doc_id	sent_index	relation_id	relation	trigger	trigger_offset	arg_num	arg_head	arg_protein	arg_domain	arg_site	arg_sugar	arg_head_offset	arg_base_np	arg_base_np_offset	arg_np	arg_np_offset	sent_text
34077200	0	0	theme	β-Cyclodextrin/Curcumin	103:125	arg1	Complex					137:143	the β-Cyclodextrin/Curcumin Inclusion Complex	99:143	the β-Cyclodextrin/Curcumin Inclusion Complex	99:143	Novel 2,3-Dialdehyde Cellulose-Based Films with Photodynamic Inactivation Potency by Incorporating the β-Cyclodextrin/Curcumin Inclusion Complex.
34077200	7	1	theme	∼4	1375:1376	arg1	CFU/g					1382:1386	∼4 Log CFU/g	1375:1386	∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2)	1375:1444	Notably, they also potently inactivated these harmful bacteria on ready-to-eat salmon with a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2).
34077200	8	2	theme	DAC-CD/Cur	1475:1484	arg1	films					1545:1549	novel and promising antimicrobial food packaging films	1496:1549	novel and promising antimicrobial food packaging films	1496:1549	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	8	2	theme	DAC-CD/Cur	1475:1484	arg1	films					1486:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	8	3	theme	antimicrobial	1516:1528	arg1	films					1486:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	8	3	theme	antimicrobial	1516:1528	arg1	films					1545:1549	novel and promising antimicrobial food packaging films	1496:1549	novel and promising antimicrobial food packaging films	1496:1549	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	4	4	theme	bonds	881:885	arg1	formation					859:867	the formation	855:867	the formation of hydrogen bonds between DAC and β-CD/Cur molecules	855:920	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	2	5	theme	PDI	368:370	arg1	potency					372:378	PDI potency	368:378	PDI potency	368:378	The objective of this study was to fabricate a green 2,3-dialdehyde cellulose (DAC)-based antimicrobial film with PDI potency by incorporating the β-cyclodextrin/curcumin (β-CD/Cur) complex as a photosensitizer.
34077200	4	6	from	water	730:734	arg1	films					708:712	the DAC-CD/Cur films	693:712	the DAC-CD/Cur films	693:712	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	4	6	from	water	730:734	arg1	strong					753:758	strong	753:758	strong	753:758	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	4	6	from	water	730:734	arg1	soluble					719:725	soluble	719:725	soluble	719:725	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	4	7	with	strong	753:758	arg1	strength					775:782	a tensile strength	765:782	a tensile strength of 63.87 MPa	765:795	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	4	7	with	strong	753:758	arg1	break					815:819	an elongation break	801:819	an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules	801:920	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	7	8	theme	CFU/g	1382:1386	arg1	%					1394:1394	99.99%	1389:1394	99.99%	1389:1394	Notably, they also potently inactivated these harmful bacteria on ready-to-eat salmon with a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2).
34077200	7	8	theme	CFU/g	1382:1386	arg1	reduction					1397:1405	∼4 Log CFU/g (99.99%) reduction	1375:1405	∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2)	1375:1444	Notably, they also potently inactivated these harmful bacteria on ready-to-eat salmon with a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2).
34077200	8	9	theme	packaging	1535:1543	arg1	films					1486:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	8	9	theme	packaging	1535:1543	arg1	films					1545:1549	novel and promising antimicrobial food packaging films	1496:1549	novel and promising antimicrobial food packaging films	1496:1549	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	5	10	theme	light	971:975	arg1	transmittance					977:989	a good light transmittance	964:989	a good light transmittance	964:989	Meanwhile, the composite films possessed a good light transmittance but impeded the penetration of ultraviolet light and efficiently delayed the degradation of curcumin.
34077200	0	11	theme	Inclusion	127:135	arg1	Complex					137:143	the β-Cyclodextrin/Curcumin Inclusion Complex	99:143	the β-Cyclodextrin/Curcumin Inclusion Complex	99:143	Novel 2,3-Dialdehyde Cellulose-Based Films with Photodynamic Inactivation Potency by Incorporating the β-Cyclodextrin/Curcumin Inclusion Complex.
34077200	8	12	theme	food	1554:1557	arg1	industry					1559:1566	food industry	1554:1566	food industry	1554:1566	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	3	13	theme	mechanical	587:596	arg1	properties					598:607	mechanical properties	587:607	mechanical properties	587:607	The PDI-mediated films were characterized by evaluating the surface morphology, chemical structure, light transmittance, mechanical properties, photochemical and thermal stability, and water solubility.
34077200	4	14	from	soluble	719:725	arg1	water					730:734	water	730:734	water	730:734	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	6	15	theme	broad-spectrum	1146:1159	arg1	ability					1161:1167	a broad-spectrum ability	1144:1167	a broad-spectrum ability to kill Listeria monocytogenes, Vibrio parahaemolyticus, and Shewanella putrefaciens in pure culture	1144:1268	More importantly, the PDI-mediated films exhibited a broad-spectrum ability to kill Listeria monocytogenes, Vibrio parahaemolyticus, and Shewanella putrefaciens in pure culture.
34077200	3	16	theme	surface	526:532	arg1	morphology					534:543	the surface morphology	522:543	the surface morphology	522:543	The PDI-mediated films were characterized by evaluating the surface morphology, chemical structure, light transmittance, mechanical properties, photochemical and thermal stability, and water solubility.
34077200	3	17	theme	light	566:570	arg1	transmittance					572:584	light transmittance	566:584	light transmittance	566:584	The PDI-mediated films were characterized by evaluating the surface morphology, chemical structure, light transmittance, mechanical properties, photochemical and thermal stability, and water solubility.
34077200	5	18	theme	composite	938:946	arg1	Meanwhile					923:931	Meanwhile	923:931	Meanwhile	923:931	Meanwhile, the composite films possessed a good light transmittance but impeded the penetration of ultraviolet light and efficiently delayed the degradation of curcumin.
34077200	5	18	theme	composite	938:946	arg1	films					948:952	the composite films	934:952	the composite films	934:952	Meanwhile, the composite films possessed a good light transmittance but impeded the penetration of ultraviolet light and efficiently delayed the degradation of curcumin.
34077200	2	19	theme	β-CD/Cur	426:433	arg1	complex					436:442	the β-cyclodextrin/curcumin (β-CD/Cur) complex	397:442	the β-cyclodextrin/curcumin (β-CD/Cur) complex	397:442	The objective of this study was to fabricate a green 2,3-dialdehyde cellulose (DAC)-based antimicrobial film with PDI potency by incorporating the β-cyclodextrin/curcumin (β-CD/Cur) complex as a photosensitizer.
34077200	2	19	theme	β-CD/Cur	426:433	arg1	photosensitizer					449:463	a photosensitizer	447:463	a photosensitizer	447:463	The objective of this study was to fabricate a green 2,3-dialdehyde cellulose (DAC)-based antimicrobial film with PDI potency by incorporating the β-cyclodextrin/curcumin (β-CD/Cur) complex as a photosensitizer.
34077200	4	20	theme	elongation	804:813	arg1	break					815:819	an elongation break	801:819	an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules	801:920	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	6	21	theme	PDI-mediated	1115:1126	arg1	films					1128:1132	the PDI-mediated films	1111:1132	the PDI-mediated films	1111:1132	More importantly, the PDI-mediated films exhibited a broad-spectrum ability to kill Listeria monocytogenes, Vibrio parahaemolyticus, and Shewanella putrefaciens in pure culture.
34077200	3	22	theme	PDI-mediated	470:481	arg1	films					483:487	The PDI-mediated films	466:487	The PDI-mediated films	466:487	The PDI-mediated films were characterized by evaluating the surface morphology, chemical structure, light transmittance, mechanical properties, photochemical and thermal stability, and water solubility.
34077200	0	23	theme	2,3-Dialdehyde	6:19	arg1	Films					37:41	Novel 2,3-Dialdehyde Cellulose-Based Films	0:41	Novel 2,3-Dialdehyde Cellulose-Based Films with Photodynamic Inactivation Potency by Incorporating the β-Cyclodextrin/Curcumin Inclusion Complex.	0:144	Novel 2,3-Dialdehyde Cellulose-Based Films with Photodynamic Inactivation Potency by Incorporating the β-Cyclodextrin/Curcumin Inclusion Complex.
34077200	4	24	theme	hydrogen	872:879	arg1	bonds					881:885	hydrogen bonds	872:885	hydrogen bonds between DAC and β-CD/Cur molecules	872:920	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	5	25	theme	ultraviolet	1022:1032	arg1	light					1034:1038	ultraviolet light	1022:1038	ultraviolet light	1022:1038	Meanwhile, the composite films possessed a good light transmittance but impeded the penetration of ultraviolet light and efficiently delayed the degradation of curcumin.
34077200	6	26	theme	Vibrio	1201:1206	arg1	parahaemolyticus					1208:1223	Vibrio parahaemolyticus	1201:1223	Vibrio parahaemolyticus	1201:1223	More importantly, the PDI-mediated films exhibited a broad-spectrum ability to kill Listeria monocytogenes, Vibrio parahaemolyticus, and Shewanella putrefaciens in pure culture.
34077200	2	27	theme	β-cyclodextrin/curcumin	401:423	arg1	complex					436:442	the β-cyclodextrin/curcumin (β-CD/Cur) complex	397:442	the β-cyclodextrin/curcumin (β-CD/Cur) complex	397:442	The objective of this study was to fabricate a green 2,3-dialdehyde cellulose (DAC)-based antimicrobial film with PDI potency by incorporating the β-cyclodextrin/curcumin (β-CD/Cur) complex as a photosensitizer.
34077200	2	27	theme	β-cyclodextrin/curcumin	401:423	arg1	photosensitizer					449:463	a photosensitizer	447:463	a photosensitizer	447:463	The objective of this study was to fabricate a green 2,3-dialdehyde cellulose (DAC)-based antimicrobial film with PDI potency by incorporating the β-cyclodextrin/curcumin (β-CD/Cur) complex as a photosensitizer.
34077200	0	28	theme	Novel	0:4	arg1	Films					37:41	Novel 2,3-Dialdehyde Cellulose-Based Films	0:41	Novel 2,3-Dialdehyde Cellulose-Based Films with Photodynamic Inactivation Potency by Incorporating the β-Cyclodextrin/Curcumin Inclusion Complex.	0:144	Novel 2,3-Dialdehyde Cellulose-Based Films with Photodynamic Inactivation Potency by Incorporating the β-Cyclodextrin/Curcumin Inclusion Complex.
34077200	1	29	theme	new	224:226	arg1	film					170:173	Antibacterial packaging film	146:173	Antibacterial packaging film mediated by photodynamic inactivation (PDI)	146:217	Antibacterial packaging film mediated by photodynamic inactivation (PDI) is a new concept in food industry.
34077200	1	29	theme	new	224:226	arg1	concept					228:234	a new concept	222:234	a new concept in food industry	222:251	Antibacterial packaging film mediated by photodynamic inactivation (PDI) is a new concept in food industry.
34077200	7	30	theme	reduction	1397:1405	arg1	maximum					1364:1370	a maximum	1362:1370	a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2)	1362:1444	Notably, they also potently inactivated these harmful bacteria on ready-to-eat salmon with a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2).
34077200	3	31	theme	water	651:655	arg1	solubility					657:666	water solubility	651:666	water solubility	651:666	The PDI-mediated films were characterized by evaluating the surface morphology, chemical structure, light transmittance, mechanical properties, photochemical and thermal stability, and water solubility.
34077200	7	32	with	salmon	1350:1355	arg1	maximum					1364:1370	a maximum	1362:1370	a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2)	1362:1444	Notably, they also potently inactivated these harmful bacteria on ready-to-eat salmon with a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2).
34077200	4	33	theme	MPa	793:795	arg1	strength					775:782	a tensile strength	765:782	a tensile strength of 63.87 MPa	765:795	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	4	33	theme	MPa	793:795	arg1	break					815:819	an elongation break	801:819	an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules	801:920	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	8	34	theme	food	1530:1533	arg1	films					1486:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	8	34	theme	food	1530:1533	arg1	films					1545:1549	novel and promising antimicrobial food packaging films	1496:1549	novel and promising antimicrobial food packaging films	1496:1549	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	0	35	theme	Cellulose-Based	21:35	arg1	Films					37:41	Novel 2,3-Dialdehyde Cellulose-Based Films	0:41	Novel 2,3-Dialdehyde Cellulose-Based Films with Photodynamic Inactivation Potency by Incorporating the β-Cyclodextrin/Curcumin Inclusion Complex.	0:144	Novel 2,3-Dialdehyde Cellulose-Based Films with Photodynamic Inactivation Potency by Incorporating the β-Cyclodextrin/Curcumin Inclusion Complex.
34077200	8	36	theme	PDI-mediated	1462:1473	arg1	films					1545:1549	novel and promising antimicrobial food packaging films	1496:1549	novel and promising antimicrobial food packaging films	1496:1549	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	8	36	theme	PDI-mediated	1462:1473	arg1	films					1486:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	1	37	theme	Antibacterial	146:158	arg1	film					170:173	Antibacterial packaging film	146:173	Antibacterial packaging film mediated by photodynamic inactivation (PDI)	146:217	Antibacterial packaging film mediated by photodynamic inactivation (PDI) is a new concept in food industry.
34077200	1	37	theme	Antibacterial	146:158	arg1	concept					228:234	a new concept	222:234	a new concept in food industry	222:251	Antibacterial packaging film mediated by photodynamic inactivation (PDI) is a new concept in food industry.
34077200	0	38	theme	Photodynamic	48:59	arg1	Potency					74:80	Photodynamic Inactivation Potency	48:80	Photodynamic Inactivation Potency	48:80	Novel 2,3-Dialdehyde Cellulose-Based Films with Photodynamic Inactivation Potency by Incorporating the β-Cyclodextrin/Curcumin Inclusion Complex.
34077200	7	39	theme	60	1413:1414	arg1	min					1416:1418	min	1416:1418	min	1416:1418	Notably, they also potently inactivated these harmful bacteria on ready-to-eat salmon with a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2).
34077200	5	40	contain	possessed	954:962	arg1	Meanwhile					923:931	Meanwhile	923:931	Meanwhile	923:931	Meanwhile, the composite films possessed a good light transmittance but impeded the penetration of ultraviolet light and efficiently delayed the degradation of curcumin.
34077200	5	40	contain	possessed	954:962	arg2	transmittance					977:989	a good light transmittance	964:989	a good light transmittance	964:989	Meanwhile, the composite films possessed a good light transmittance but impeded the penetration of ultraviolet light and efficiently delayed the degradation of curcumin.
34077200	5	40	contain	possessed	954:962	arg1	films					948:952	the composite films	934:952	the composite films	934:952	Meanwhile, the composite films possessed a good light transmittance but impeded the penetration of ultraviolet light and efficiently delayed the degradation of curcumin.
34077200	1	41	theme	food	239:242	arg1	industry					244:251	food industry	239:251	food industry	239:251	Antibacterial packaging film mediated by photodynamic inactivation (PDI) is a new concept in food industry.
34077200	7	42	theme	Log	1378:1380	arg1	CFU/g					1382:1386	∼4 Log CFU/g	1375:1386	∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2)	1375:1444	Notably, they also potently inactivated these harmful bacteria on ready-to-eat salmon with a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2).
34077200	8	43	from	films	1545:1549	arg1	industry					1559:1566	food industry	1554:1566	food industry	1554:1566	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	7	44	theme	min	1416:1418	arg1	irradiation					1420:1430	60 min irradiation	1413:1430	60 min irradiation (13.68 J/cm2)	1413:1444	Notably, they also potently inactivated these harmful bacteria on ready-to-eat salmon with a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2).
34077200	7	44	theme	min	1416:1418	arg1	J/cm2					1439:1443	13.68 J/cm2	1433:1443	13.68 J/cm2	1433:1443	Notably, they also potently inactivated these harmful bacteria on ready-to-eat salmon with a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2).
34077200	0	45	with	Films	37:41	arg1	Potency					74:80	Photodynamic Inactivation Potency	48:80	Photodynamic Inactivation Potency	48:80	Novel 2,3-Dialdehyde Cellulose-Based Films with Photodynamic Inactivation Potency by Incorporating the β-Cyclodextrin/Curcumin Inclusion Complex.
34077200	2	46	with	film	358:361	arg1	potency					372:378	PDI potency	368:378	PDI potency	368:378	The objective of this study was to fabricate a green 2,3-dialdehyde cellulose (DAC)-based antimicrobial film with PDI potency by incorporating the β-cyclodextrin/curcumin (β-CD/Cur) complex as a photosensitizer.
34077200	3	47	theme	thermal	628:634	arg1	stability					636:644	thermal stability	628:644	thermal stability	628:644	The PDI-mediated films were characterized by evaluating the surface morphology, chemical structure, light transmittance, mechanical properties, photochemical and thermal stability, and water solubility.
34077200	1	48	theme	packaging	160:168	arg1	film					170:173	Antibacterial packaging film	146:173	Antibacterial packaging film mediated by photodynamic inactivation (PDI)	146:217	Antibacterial packaging film mediated by photodynamic inactivation (PDI) is a new concept in food industry.
34077200	1	48	theme	packaging	160:168	arg1	concept					228:234	a new concept	222:234	a new concept in food industry	222:251	Antibacterial packaging film mediated by photodynamic inactivation (PDI) is a new concept in food industry.
34077200	0	49	theme	Inactivation	61:72	arg1	Potency					74:80	Photodynamic Inactivation Potency	48:80	Photodynamic Inactivation Potency	48:80	Novel 2,3-Dialdehyde Cellulose-Based Films with Photodynamic Inactivation Potency by Incorporating the β-Cyclodextrin/Curcumin Inclusion Complex.
34077200	4	50	theme	β-CD/Cur	903:910	arg1	molecules					912:920	β-CD/Cur molecules	903:920	β-CD/Cur molecules	903:920	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	8	51	theme	novel	1496:1500	arg1	films					1486:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	8	51	theme	novel	1496:1500	arg1	films					1545:1549	novel and promising antimicrobial food packaging films	1496:1549	novel and promising antimicrobial food packaging films	1496:1549	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	1	52	from	concept	228:234	arg1	industry					244:251	food industry	239:251	food industry	239:251	Antibacterial packaging film mediated by photodynamic inactivation (PDI) is a new concept in food industry.
34077200	7	53	theme	ready-to-eat	1337:1348	arg1	salmon					1350:1355	ready-to-eat salmon	1337:1355	ready-to-eat salmon with a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2)	1337:1444	Notably, they also potently inactivated these harmful bacteria on ready-to-eat salmon with a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2).
34077200	5	54	theme	light	1034:1038	arg1	penetration					1007:1017	the penetration	1003:1017	the penetration of ultraviolet light	1003:1038	Meanwhile, the composite films possessed a good light transmittance but impeded the penetration of ultraviolet light and efficiently delayed the degradation of curcumin.
34077200	3	55	theme	chemical	546:553	arg1	structure					555:563	chemical structure	546:563	chemical structure	546:563	The PDI-mediated films were characterized by evaluating the surface morphology, chemical structure, light transmittance, mechanical properties, photochemical and thermal stability, and water solubility.
34077200	4	56	dep	soluble	719:725	arg1	films					708:712	the DAC-CD/Cur films	693:712	the DAC-CD/Cur films	693:712	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	4	56	dep	soluble	719:725	arg1	strong					753:758	strong	753:758	strong	753:758	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	4	56	dep	soluble	719:725	arg1	soluble					719:725	soluble	719:725	soluble	719:725	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	2	57	theme	antimicrobial	344:356	arg1	film					358:361	a green 2,3-dialdehyde cellulose (DAC)-based antimicrobial film	299:361	a green 2,3-dialdehyde cellulose (DAC)-based antimicrobial film with PDI potency	299:378	The objective of this study was to fabricate a green 2,3-dialdehyde cellulose (DAC)-based antimicrobial film with PDI potency by incorporating the β-cyclodextrin/curcumin (β-CD/Cur) complex as a photosensitizer.
34077200	5	58	theme	good	966:969	arg1	transmittance					977:989	a good light transmittance	964:989	a good light transmittance	964:989	Meanwhile, the composite films possessed a good light transmittance but impeded the penetration of ultraviolet light and efficiently delayed the degradation of curcumin.
34077200	5	59	theme	curcumin	1083:1090	arg1	degradation					1068:1078	the degradation	1064:1078	the degradation of curcumin	1064:1090	Meanwhile, the composite films possessed a good light transmittance but impeded the penetration of ultraviolet light and efficiently delayed the degradation of curcumin.
34077200	6	60	theme	pure	1257:1260	arg1	culture					1262:1268	pure culture	1257:1268	pure culture	1257:1268	More importantly, the PDI-mediated films exhibited a broad-spectrum ability to kill Listeria monocytogenes, Vibrio parahaemolyticus, and Shewanella putrefaciens in pure culture.
34077200	2	61	theme	-based	337:342	arg1	film					358:361	a green 2,3-dialdehyde cellulose (DAC)-based antimicrobial film	299:361	a green 2,3-dialdehyde cellulose (DAC)-based antimicrobial film with PDI potency	299:378	The objective of this study was to fabricate a green 2,3-dialdehyde cellulose (DAC)-based antimicrobial film with PDI potency by incorporating the β-cyclodextrin/curcumin (β-CD/Cur) complex as a photosensitizer.
34077200	4	62	theme	tensile	767:773	arg1	strength					775:782	a tensile strength	765:782	a tensile strength of 63.87 MPa	765:795	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	2	63	theme	study	276:280	arg1	objective					258:266	The objective	254:266	The objective of this study	254:280	The objective of this study was to fabricate a green 2,3-dialdehyde cellulose (DAC)-based antimicrobial film with PDI potency by incorporating the β-cyclodextrin/curcumin (β-CD/Cur) complex as a photosensitizer.
34077200	1	64	theme	photodynamic	187:198	arg1	inactivation					200:211	photodynamic inactivation	187:211	photodynamic inactivation (PDI)	187:217	Antibacterial packaging film mediated by photodynamic inactivation (PDI) is a new concept in food industry.
34077200	1	64	theme	photodynamic	187:198	arg1	PDI					214:216	PDI	214:216	PDI	214:216	Antibacterial packaging film mediated by photodynamic inactivation (PDI) is a new concept in food industry.
34077200	4	65	theme	DAC-CD/Cur	697:706	arg1	films					708:712	the DAC-CD/Cur films	693:712	the DAC-CD/Cur films	693:712	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	4	65	theme	DAC-CD/Cur	697:706	arg1	strong					753:758	strong	753:758	strong	753:758	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	4	65	theme	DAC-CD/Cur	697:706	arg1	soluble					719:725	soluble	719:725	soluble	719:725	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	6	66	theme	Listeria	1177:1184	arg1	monocytogenes					1186:1198	Listeria monocytogenes	1177:1198	Listeria monocytogenes	1177:1198	More importantly, the PDI-mediated films exhibited a broad-spectrum ability to kill Listeria monocytogenes, Vibrio parahaemolyticus, and Shewanella putrefaciens in pure culture.
34077200	4	67	theme	%	828:828	arg1	strength					775:782	a tensile strength	765:782	a tensile strength of 63.87 MPa	765:795	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	4	67	theme	%	828:828	arg1	break					815:819	an elongation break	801:819	an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules	801:920	The results showed that the DAC-CD/Cur films were soluble in water and mechanically strong with a tensile strength of 63.87 MPa and an elongation break of 1.32%, which was attributed to the formation of hydrogen bonds between DAC and β-CD/Cur molecules.
34077200	7	68	theme	harmful	1317:1323	arg1	bacteria					1325:1332	these harmful bacteria	1311:1332	these harmful bacteria	1311:1332	Notably, they also potently inactivated these harmful bacteria on ready-to-eat salmon with a maximum of ∼4 Log CFU/g (99.99%) reduction after 60 min irradiation (13.68 J/cm2).
34077200	8	69	theme	promising	1506:1514	arg1	films					1486:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	the PDI-mediated DAC-CD/Cur films	1458:1490	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
34077200	8	69	theme	promising	1506:1514	arg1	films					1545:1549	novel and promising antimicrobial food packaging films	1496:1549	novel and promising antimicrobial food packaging films	1496:1549	Therefore, the PDI-mediated DAC-CD/Cur films are novel and promising antimicrobial food packaging films in food industry.
33400948	2	0	theme	grafted	341:347	arg1	chitosan					349:356	a new poly(allyltrimethylammonium) grafted chitosan	306:356	a new poly(allyltrimethylammonium) grafted chitosan	306:356	Herein, a new poly(allyltrimethylammonium) grafted chitosan and biochar composite (PATMAC-CTS-BC) was introduced for the removal of selenate (SeO42-) in water.
33400948	8	1	theme	anion	1385:1389	arg1	capability					1399:1408	the anion removal capability	1381:1408	the anion removal capability of cationic hydrogel-BC composite	1381:1442	Besides SeO42-, the hexavalent chromium (Cr2O72-) was considered as example to further demonstrate the anion removal capability of cationic hydrogel-BC composite.
33400948	0	2	from	removal	10:16	arg1	water					33:37	water	33:37	water	33:37	Efficient removal of selenate in water by cationic poly(allyltrimethylammonium) grafted chitosan and biochar composite.
33400948	7	3	with	groups	1205:1210	arg1	groups					1274:1279	-OH groups	1270:1279	-OH groups	1270:1279	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	7	3	with	groups	1205:1210	arg1	=N+-					1179:1182	=N+-	1179:1182	=N+-	1179:1182	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	7	3	with	groups	1205:1210	arg1	-NH-					1260:1263	-NH-	1260:1263	-NH-	1260:1263	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	7	3	with	groups	1205:1210	arg1	-NH2					1254:1257	-NH2	1254:1257	-NH2	1254:1257	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	5	4	theme	SeO42-	870:875	arg1	adsorption					877:886	SeO42- adsorption	870:886	SeO42- adsorption onto the composite	870:905	The thermodynamic results reflected the spontaneous and exothermic nature of SeO42- adsorption onto the composite.
33400948	1	5	theme	eco-friendly	147:158	arg1	materials					171:179	cheap and eco-friendly functional materials	137:179	cheap and eco-friendly functional materials	137:179	The discovery of cheap and eco-friendly functional materials for the removal of anionic heavy metal ions is still challenging in the treatment of heavy metal-contaminated water.
33400948	7	6	theme	electrostatic	1147:1159	arg1	interactions					1161:1172	electrostatic interactions	1147:1172	electrostatic interactions with =N+-	1147:1182	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	9	7	theme	new	1472:1474	arg1	opportunities					1476:1488	new opportunities	1472:1488	new opportunities	1472:1488	The study outcomes open up new opportunities to efficiently remove anionic heavy metal ions (e.g., SeO42- and Cr2O72-) in water using these materials.
33400948	4	8	theme	Langmuir	723:730	arg1	model					732:736	Langmuir model	723:736	Langmuir model	723:736	High capacity of SeO42- adsorption by the composite was achieved, with maximum value of 98.99 mg g-1 based on Langmuir model, considerably higher than most of reported adsorbents.
33400948	4	8	theme	Langmuir	723:730	arg1	higher					752:757	higher	752:757	higher	752:757	High capacity of SeO42- adsorption by the composite was achieved, with maximum value of 98.99 mg g-1 based on Langmuir model, considerably higher than most of reported adsorbents.
33400948	6	9	theme	pH	957:958	arg1	range					960:964	a wide initial pH range (2-10)	942:971	a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-)	942:1085	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	7	10	theme	redox-complexation	1217:1234	arg1	interactions					1236:1247	redox-complexation interactions	1217:1247	redox-complexation interactions with -NH2, -NH-, and -OH groups	1217:1279	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	4	11	theme	maximum	684:690	arg1	value					692:696	maximum value	684:696	maximum value of 98.99 mg g-1 based on Langmuir model, considerably higher than most of reported adsorbents	684:790	High capacity of SeO42- adsorption by the composite was achieved, with maximum value of 98.99 mg g-1 based on Langmuir model, considerably higher than most of reported adsorbents.
33400948	4	12	theme	High	613:616	arg1	capacity					618:625	High capacity	613:625	High capacity of SeO42- adsorption by the composite	613:663	High capacity of SeO42- adsorption by the composite was achieved, with maximum value of 98.99 mg g-1 based on Langmuir model, considerably higher than most of reported adsorbents.
33400948	0	13	theme	biochar	101:107	arg1	composite					109:117	biochar composite	101:117	biochar composite	101:117	Efficient removal of selenate in water by cationic poly(allyltrimethylammonium) grafted chitosan and biochar composite.
33400948	7	14	theme	SeO42-	1114:1119	arg1	mechanisms					1100:1109	The removal mechanisms	1088:1109	The removal mechanisms of SeO42-	1088:1119	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	6	15	theme	positive	1033:1040	arg1	charges					1042:1048	permanent positive charges	1023:1048	permanent positive charges of quaternary ammonium groups (=N+-)	1023:1085	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	8	16	theme	hexavalent	1302:1311	arg1	example					1350:1356	example	1350:1356	example	1350:1356	Besides SeO42-, the hexavalent chromium (Cr2O72-) was considered as example to further demonstrate the anion removal capability of cationic hydrogel-BC composite.
33400948	8	16	theme	hexavalent	1302:1311	arg1	Cr2O72-					1323:1329	Cr2O72-	1323:1329	Cr2O72-	1323:1329	Besides SeO42-, the hexavalent chromium (Cr2O72-) was considered as example to further demonstrate the anion removal capability of cationic hydrogel-BC composite.
33400948	8	16	theme	hexavalent	1302:1311	arg1	chromium					1313:1320	the hexavalent chromium	1298:1320	the hexavalent chromium (Cr2O72-)	1298:1330	Besides SeO42-, the hexavalent chromium (Cr2O72-) was considered as example to further demonstrate the anion removal capability of cationic hydrogel-BC composite.
33400948	7	17	theme	-OH	1270:1272	arg1	groups					1274:1279	-OH groups	1270:1279	-OH groups	1270:1279	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	1	18	theme	functional	160:169	arg1	materials					171:179	cheap and eco-friendly functional materials	137:179	cheap and eco-friendly functional materials	137:179	The discovery of cheap and eco-friendly functional materials for the removal of anionic heavy metal ions is still challenging in the treatment of heavy metal-contaminated water.
33400948	6	19	theme	initial	949:955	arg1	range					960:964	a wide initial pH range (2-10)	942:971	a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-)	942:1085	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	0	20	from	water	33:37	arg1	removal					10:16	Efficient removal	0:16	Efficient removal of selenate in water by cationic poly(allyltrimethylammonium)	0:78	Efficient removal of selenate in water by cationic poly(allyltrimethylammonium) grafted chitosan and biochar composite.
33400948	7	21	with	interactions	1236:1247	arg1	groups					1274:1279	-OH groups	1270:1279	-OH groups	1270:1279	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	7	21	with	interactions	1236:1247	arg1	-NH-					1260:1263	-NH-	1260:1263	-NH-	1260:1263	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	7	21	with	interactions	1236:1247	arg1	=N+-					1179:1182	=N+-	1179:1182	=N+-	1179:1182	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	7	21	with	interactions	1236:1247	arg1	-NH2					1254:1257	-NH2	1254:1257	-NH2	1254:1257	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	3	22	theme	rapid	506:510	arg1	removal					512:518	a rapid removal	504:518	a rapid removal of SeO42-	504:528	Results suggest that the PATMAC-CTS-BC showed a rapid removal of SeO42- with efficiency of >97% within 10 min and it followed a pseudo-second-order model.
33400948	6	23	theme	charges	1042:1048	arg1	efficiency					991:1000	high removal efficiency	978:1000	high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-)	978:1085	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	1	24	theme	materials	171:179	arg1	discovery					124:132	The discovery	120:132	The discovery of cheap and eco-friendly functional materials for the removal of anionic heavy metal ions	120:223	The discovery of cheap and eco-friendly functional materials for the removal of anionic heavy metal ions is still challenging in the treatment of heavy metal-contaminated water.
33400948	2	25	theme	selenate	430:437	arg1	removal					419:425	the removal	415:425	the removal of selenate (SeO42-) in water	415:455	Herein, a new poly(allyltrimethylammonium) grafted chitosan and biochar composite (PATMAC-CTS-BC) was introduced for the removal of selenate (SeO42-) in water.
33400948	5	26	theme	adsorption	877:886	arg1	nature					860:865	the spontaneous and exothermic nature	829:865	the spontaneous and exothermic nature of SeO42- adsorption onto the composite	829:905	The thermodynamic results reflected the spontaneous and exothermic nature of SeO42- adsorption onto the composite.
33400948	9	27	theme	metal	1526:1530	arg1	ions					1532:1535	anionic heavy metal ions	1512:1535	anionic heavy metal ions (e.g., SeO42- and Cr2O72-) in water using these materials	1512:1593	The study outcomes open up new opportunities to efficiently remove anionic heavy metal ions (e.g., SeO42- and Cr2O72-) in water using these materials.
33400948	4	28	theme	adsorption	637:646	arg1	capacity					618:625	High capacity	613:625	High capacity of SeO42- adsorption by the composite	613:663	High capacity of SeO42- adsorption by the composite was achieved, with maximum value of 98.99 mg g-1 based on Langmuir model, considerably higher than most of reported adsorbents.
33400948	0	29	theme	Efficient	0:8	arg1	removal					10:16	Efficient removal	0:16	Efficient removal of selenate in water by cationic poly(allyltrimethylammonium)	0:78	Efficient removal of selenate in water by cationic poly(allyltrimethylammonium) grafted chitosan and biochar composite.
33400948	6	30	theme	wide	944:947	arg1	range					960:964	a wide initial pH range (2-10)	942:971	a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-)	942:1085	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	8	31	theme	composite	1434:1442	arg1	capability					1399:1408	the anion removal capability	1381:1408	the anion removal capability of cationic hydrogel-BC composite	1381:1442	Besides SeO42-, the hexavalent chromium (Cr2O72-) was considered as example to further demonstrate the anion removal capability of cationic hydrogel-BC composite.
33400948	2	32	theme	biochar	362:368	arg1	PATMAC-CTS-BC					381:393	PATMAC-CTS-BC	381:393	PATMAC-CTS-BC	381:393	Herein, a new poly(allyltrimethylammonium) grafted chitosan and biochar composite (PATMAC-CTS-BC) was introduced for the removal of selenate (SeO42-) in water.
33400948	2	32	theme	biochar	362:368	arg1	composite					370:378	biochar composite	362:378	biochar composite (PATMAC-CTS-BC)	362:394	Herein, a new poly(allyltrimethylammonium) grafted chitosan and biochar composite (PATMAC-CTS-BC) was introduced for the removal of selenate (SeO42-) in water.
33400948	0	33	theme	selenate	21:28	arg1	removal					10:16	Efficient removal	0:16	Efficient removal of selenate in water by cationic poly(allyltrimethylammonium)	0:78	Efficient removal of selenate in water by cationic poly(allyltrimethylammonium) grafted chitosan and biochar composite.
33400948	1	34	theme	heavy	266:270	arg1	water					291:295	heavy metal-contaminated water	266:295	heavy metal-contaminated water	266:295	The discovery of cheap and eco-friendly functional materials for the removal of anionic heavy metal ions is still challenging in the treatment of heavy metal-contaminated water.
33400948	9	35	from	ions	1532:1535	arg1	water					1567:1571	water	1567:1571	water using these materials	1567:1593	The study outcomes open up new opportunities to efficiently remove anionic heavy metal ions (e.g., SeO42- and Cr2O72-) in water using these materials.
33400948	7	36	with	interactions	1161:1172	arg1	groups					1274:1279	-OH groups	1270:1279	-OH groups	1270:1279	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	7	36	with	interactions	1161:1172	arg1	=N+-					1179:1182	=N+-	1179:1182	=N+-	1179:1182	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	7	36	with	interactions	1161:1172	arg1	-NH-					1260:1263	-NH-	1260:1263	-NH-	1260:1263	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	7	36	with	interactions	1161:1172	arg1	-NH2					1254:1257	-NH2	1254:1257	-NH2	1254:1257	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	3	37	theme	SeO42-	523:528	arg1	removal					512:518	a rapid removal	504:518	a rapid removal of SeO42-	504:528	Results suggest that the PATMAC-CTS-BC showed a rapid removal of SeO42- with efficiency of >97% within 10 min and it followed a pseudo-second-order model.
33400948	6	38	theme	permanent	1023:1031	arg1	charges					1042:1048	permanent positive charges	1023:1048	permanent positive charges of quaternary ammonium groups (=N+-)	1023:1085	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	6	39	theme	SeO42-	1005:1010	arg1	efficiency					991:1000	high removal efficiency	978:1000	high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-)	978:1085	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	6	40	theme	groups	1073:1078	arg1	charges					1042:1048	permanent positive charges	1023:1048	permanent positive charges of quaternary ammonium groups (=N+-)	1023:1085	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	1	41	theme	metal-contaminated	272:289	arg1	water					291:295	heavy metal-contaminated water	266:295	heavy metal-contaminated water	266:295	The discovery of cheap and eco-friendly functional materials for the removal of anionic heavy metal ions is still challenging in the treatment of heavy metal-contaminated water.
33400948	9	42	theme	anionic	1512:1518	arg1	ions					1532:1535	anionic heavy metal ions	1512:1535	anionic heavy metal ions (e.g., SeO42- and Cr2O72-) in water using these materials	1512:1593	The study outcomes open up new opportunities to efficiently remove anionic heavy metal ions (e.g., SeO42- and Cr2O72-) in water using these materials.
33400948	8	43	theme	removal	1391:1397	arg1	capability					1399:1408	the anion removal capability	1381:1408	the anion removal capability of cationic hydrogel-BC composite	1381:1442	Besides SeO42-, the hexavalent chromium (Cr2O72-) was considered as example to further demonstrate the anion removal capability of cationic hydrogel-BC composite.
33400948	4	44	theme	98.99 mg g-1	701:712	arg1	value					692:696	maximum value	684:696	maximum value of 98.99 mg g-1 based on Langmuir model, considerably higher than most of reported adsorbents	684:790	High capacity of SeO42- adsorption by the composite was achieved, with maximum value of 98.99 mg g-1 based on Langmuir model, considerably higher than most of reported adsorbents.
33400948	5	45	theme	thermodynamic	797:809	arg1	results					811:817	The thermodynamic results	793:817	The thermodynamic results	793:817	The thermodynamic results reflected the spontaneous and exothermic nature of SeO42- adsorption onto the composite.
33400948	7	46	theme	removal	1092:1098	arg1	mechanisms					1100:1109	The removal mechanisms	1088:1109	The removal mechanisms of SeO42-	1088:1119	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	1	47	theme	water	291:295	arg1	treatment					253:261	the treatment	249:261	the treatment of heavy metal-contaminated water	249:295	The discovery of cheap and eco-friendly functional materials for the removal of anionic heavy metal ions is still challenging in the treatment of heavy metal-contaminated water.
33400948	2	48	from	water	451:455	arg1	removal					419:425	the removal	415:425	the removal of selenate (SeO42-) in water	415:455	Herein, a new poly(allyltrimethylammonium) grafted chitosan and biochar composite (PATMAC-CTS-BC) was introduced for the removal of selenate (SeO42-) in water.
33400948	4	49	theme	reported	772:779	arg1	adsorbents					781:790	reported adsorbents	772:790	reported adsorbents	772:790	High capacity of SeO42- adsorption by the composite was achieved, with maximum value of 98.99 mg g-1 based on Langmuir model, considerably higher than most of reported adsorbents.
33400948	4	50	theme	SeO42-	630:635	arg1	adsorption					637:646	SeO42- adsorption	630:646	SeO42- adsorption by the composite	630:663	High capacity of SeO42- adsorption by the composite was achieved, with maximum value of 98.99 mg g-1 based on Langmuir model, considerably higher than most of reported adsorbents.
33400948	1	51	theme	anionic	200:206	arg1	ions					220:223	anionic heavy metal ions	200:223	anionic heavy metal ions	200:223	The discovery of cheap and eco-friendly functional materials for the removal of anionic heavy metal ions is still challenging in the treatment of heavy metal-contaminated water.
33400948	6	52	theme	high	978:981	arg1	efficiency					991:1000	high removal efficiency	978:1000	high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-)	978:1085	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	3	53	theme	pseudo-second-order	586:604	arg1	model					606:610	a pseudo-second-order model	584:610	a pseudo-second-order model	584:610	Results suggest that the PATMAC-CTS-BC showed a rapid removal of SeO42- with efficiency of >97% within 10 min and it followed a pseudo-second-order model.
33400948	1	54	theme	heavy	208:212	arg1	ions					220:223	anionic heavy metal ions	200:223	anionic heavy metal ions	200:223	The discovery of cheap and eco-friendly functional materials for the removal of anionic heavy metal ions is still challenging in the treatment of heavy metal-contaminated water.
33400948	0	55	theme	cationic	42:49	arg1	allyltrimethylammonium					56:77	allyltrimethylammonium	56:77	allyltrimethylammonium	56:77	Efficient removal of selenate in water by cationic poly(allyltrimethylammonium) grafted chitosan and biochar composite.
33400948	0	55	theme	cationic	42:49	arg1	poly					51:54	cationic poly	42:54	cationic poly(allyltrimethylammonium)	42:78	Efficient removal of selenate in water by cationic poly(allyltrimethylammonium) grafted chitosan and biochar composite.
33400948	9	56	dep	SeO42-	1544:1549	arg1	e.g.					1538:1541	e.g.	1538:1541	e.g.	1538:1541	The study outcomes open up new opportunities to efficiently remove anionic heavy metal ions (e.g., SeO42- and Cr2O72-) in water using these materials.
33400948	6	57	theme	quaternary	1053:1062	arg1	=N+-					1081:1084	=N+-	1081:1084	=N+-	1081:1084	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	6	57	theme	quaternary	1053:1062	arg1	groups					1073:1078	quaternary ammonium groups	1053:1078	quaternary ammonium groups (=N+-)	1053:1085	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	2	58	theme	allyltrimethylammonium	317:338	arg1	chitosan					349:356	a new poly(allyltrimethylammonium) grafted chitosan	306:356	a new poly(allyltrimethylammonium) grafted chitosan	306:356	Herein, a new poly(allyltrimethylammonium) grafted chitosan and biochar composite (PATMAC-CTS-BC) was introduced for the removal of selenate (SeO42-) in water.
33400948	2	59	from	removal	419:425	arg1	water					451:455	water	451:455	water	451:455	Herein, a new poly(allyltrimethylammonium) grafted chitosan and biochar composite (PATMAC-CTS-BC) was introduced for the removal of selenate (SeO42-) in water.
33400948	8	60	theme	hydrogel-BC	1422:1432	arg1	composite					1434:1442	cationic hydrogel-BC composite	1413:1442	cationic hydrogel-BC composite	1413:1442	Besides SeO42-, the hexavalent chromium (Cr2O72-) was considered as example to further demonstrate the anion removal capability of cationic hydrogel-BC composite.
33400948	3	61	theme	%	552:552	arg1	efficiency					535:544	efficiency	535:544	efficiency of >97%	535:552	Results suggest that the PATMAC-CTS-BC showed a rapid removal of SeO42- with efficiency of >97% within 10 min and it followed a pseudo-second-order model.
33400948	9	62	theme	study	1449:1453	arg1	outcomes					1455:1462	The study outcomes	1445:1462	The study outcomes	1445:1462	The study outcomes open up new opportunities to efficiently remove anionic heavy metal ions (e.g., SeO42- and Cr2O72-) in water using these materials.
33400948	8	63	theme	cationic	1413:1420	arg1	composite					1434:1442	cationic hydrogel-BC composite	1413:1442	cationic hydrogel-BC composite	1413:1442	Besides SeO42-, the hexavalent chromium (Cr2O72-) was considered as example to further demonstrate the anion removal capability of cationic hydrogel-BC composite.
33400948	2	64	theme	poly	312:315	arg1	chitosan					349:356	a new poly(allyltrimethylammonium) grafted chitosan	306:356	a new poly(allyltrimethylammonium) grafted chitosan	306:356	Herein, a new poly(allyltrimethylammonium) grafted chitosan and biochar composite (PATMAC-CTS-BC) was introduced for the removal of selenate (SeO42-) in water.
33400948	5	65	theme	exothermic	849:858	arg1	nature					860:865	the spontaneous and exothermic nature	829:865	the spontaneous and exothermic nature of SeO42- adsorption onto the composite	829:905	The thermodynamic results reflected the spontaneous and exothermic nature of SeO42- adsorption onto the composite.
33400948	1	66	theme	metal	214:218	arg1	ions					220:223	anionic heavy metal ions	200:223	anionic heavy metal ions	200:223	The discovery of cheap and eco-friendly functional materials for the removal of anionic heavy metal ions is still challenging in the treatment of heavy metal-contaminated water.
33400948	9	67	theme	heavy	1520:1524	arg1	ions					1532:1535	anionic heavy metal ions	1512:1535	anionic heavy metal ions (e.g., SeO42- and Cr2O72-) in water using these materials	1512:1593	The study outcomes open up new opportunities to efficiently remove anionic heavy metal ions (e.g., SeO42- and Cr2O72-) in water using these materials.
33400948	2	68	theme	new	308:310	arg1	chitosan					349:356	a new poly(allyltrimethylammonium) grafted chitosan	306:356	a new poly(allyltrimethylammonium) grafted chitosan	306:356	Herein, a new poly(allyltrimethylammonium) grafted chitosan and biochar composite (PATMAC-CTS-BC) was introduced for the removal of selenate (SeO42-) in water.
33400948	1	69	theme	ions	220:223	arg1	removal					189:195	the removal	185:195	the removal of anionic heavy metal ions	185:223	The discovery of cheap and eco-friendly functional materials for the removal of anionic heavy metal ions is still challenging in the treatment of heavy metal-contaminated water.
33400948	2	70	from	selenate	430:437	arg1	water					451:455	water	451:455	water	451:455	Herein, a new poly(allyltrimethylammonium) grafted chitosan and biochar composite (PATMAC-CTS-BC) was introduced for the removal of selenate (SeO42-) in water.
33400948	6	71	theme	removal	983:989	arg1	efficiency					991:1000	high removal efficiency	978:1000	high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-)	978:1085	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	6	72	theme	ammonium	1064:1071	arg1	=N+-					1081:1084	=N+-	1081:1084	=N+-	1081:1084	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	6	72	theme	ammonium	1064:1071	arg1	groups					1073:1078	quaternary ammonium groups	1053:1078	quaternary ammonium groups (=N+-)	1053:1085	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	5	73	theme	spontaneous	833:843	arg1	nature					860:865	the spontaneous and exothermic nature	829:865	the spontaneous and exothermic nature of SeO42- adsorption onto the composite	829:905	The thermodynamic results reflected the spontaneous and exothermic nature of SeO42- adsorption onto the composite.
33400948	7	74	theme	protonated	1188:1197	arg1	groups					1205:1210	protonated -NH3+ groups	1188:1210	protonated -NH3+ groups	1188:1210	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33400948	0	75	from	selenate	21:28	arg1	water					33:37	water	33:37	water	33:37	Efficient removal of selenate in water by cationic poly(allyltrimethylammonium) grafted chitosan and biochar composite.
33400948	6	76	with	range	960:964	arg1	efficiency					991:1000	high removal efficiency	978:1000	high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-)	978:1085	The composite could be applied at a wide initial pH range (2-10) with high removal efficiency of SeO42- because of permanent positive charges of quaternary ammonium groups (=N+-).
33400948	1	77	theme	cheap	137:141	arg1	materials					171:179	cheap and eco-friendly functional materials	137:179	cheap and eco-friendly functional materials	137:179	The discovery of cheap and eco-friendly functional materials for the removal of anionic heavy metal ions is still challenging in the treatment of heavy metal-contaminated water.
33400948	7	78	theme	-NH3+	1199:1203	arg1	groups					1205:1210	protonated -NH3+ groups	1188:1210	protonated -NH3+ groups	1188:1210	The removal mechanisms of SeO42- were mainly attributed to electrostatic interactions with =N+- and protonated -NH3+ groups, and redox-complexation interactions with -NH2, -NH-, and -OH groups.
33722623	4	0	from	26.71 nm	788:795	arg1	size					813:816	size	813:816	size	813:816	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
33722623	4	1	from	35.60 nm	801:808	arg1	size					813:816	size	813:816	size	813:816	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
33722623	5	2	theme	31.98	933:937	arg1	mF					939:940	mF	939:940	mF	939:940	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	1	3	theme	CMC	193:195	arg1	film					205:208	porous carboxymethyl cellulose (CMC) carbon film	161:208	porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials	161:245	The present work developed porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials as supercapacitor electrode.
33722623	5	4	theme	24.15	962:966	arg1	mF					968:969	mF	968:969	mF	968:969	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	3	5	theme	CMC	533:535	arg1	carbon					537:542	porous CMC carbon	526:542	porous CMC carbon whereby CMCB exhibited higher surface area than CMCO	526:595	The carbonization produced porous CMC carbon whereby CMCB exhibited higher surface area than CMCO.
33722623	5	6	theme	Mn2O3/CMCO	979:988	arg1	film					1000:1003	Mn2O3/CMCO composite film	979:1003	Mn2O3/CMCO composite film	979:1003	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	0	7	theme	supercapacitor	106:119	arg1	application					121:131	supercapacitor application	106:131	supercapacitor application	106:131	Porous carboxymethyl cellulose carbon of lignocellulosic based materials incorporated manganese oxide for supercapacitor application.
33722623	3	8	theme	higher	567:572	arg1	area					582:585	higher surface area	567:585	higher surface area	567:585	The carbonization produced porous CMC carbon whereby CMCB exhibited higher surface area than CMCO.
33722623	2	9	theme	B	311:311	arg1	films					294:298	Porous CMC carbon films	276:298	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O)	276:347	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	2	10	theme	fruit	333:337	arg1	bunch					339:343	bamboo (B) and oil palm empty fruit bunch	303:343	bunch	339:343	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	5	11	theme	Mn2O3/CMCB	852:861	arg1	film					873:876	the Mn2O3/CMCB composite film	848:876	the Mn2O3/CMCB composite film	848:876	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	6	12	theme	oil	1195:1197	arg1	fruit					1204:1208	oil palm fruit	1195:1208	oil palm fruit	1195:1208	Therefore, it can be highlighted that Mn2O3/CMC composite film as prepared from bamboo and oil palm fruit can potentially become the new electrode materials for supercapacitor application.
33722623	5	13	theme	electrochemical	895:909	arg1	performance					911:921	higher electrochemical performance	888:921	higher electrochemical performance	888:921	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	2	14	theme	impregnation	396:407	arg1	method					409:414	simple incipient wetness impregnation method	371:414	simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3)	371:496	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	2	15	theme	manganese	474:482	arg1	oxide					484:488	manganese oxide	474:488	manganese oxide (Mn2O3)	474:496	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	2	15	theme	manganese	474:482	arg1	Mn2O3					491:495	Mn2O3	491:495	Mn2O3	491:495	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	5	16	theme	mF	939:940	arg1	cm-2					942:945	31.98 mF cm-2	933:945	31.98 mF cm-2	933:945	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	4	17	theme	CMCB	649:652	arg1	50.09 nm					682:689	50.09 nm	682:689	50.09 nm	682:689	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
33722623	4	17	theme	CMCB	649:652	arg1	42.76 nm					695:702	42.76 nm	695:702	42.76 nm	695:702	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
33722623	4	17	theme	CMCB	649:652	arg1	size					641:644	the crystallite size	625:644	the crystallite size of CMCB and CMCO	625:661	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
33722623	2	18	theme	bamboo	303:308	arg1	B					311:311	bamboo (B) and oil palm empty fruit bunch	303:343	B	311:311	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	2	18	theme	bamboo	303:308	arg1	O					346:346	O	346:346	O	346:346	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	1	19	theme	carbon	198:203	arg1	film					205:208	porous carboxymethyl cellulose (CMC) carbon film	161:208	porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials	161:245	The present work developed porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials as supercapacitor electrode.
33722623	0	20	theme	carboxymethyl	7:19	arg1	carbon					31:36	Porous carboxymethyl cellulose carbon	0:36	Porous carboxymethyl cellulose carbon of lignocellulosic based materials	0:71	Porous carboxymethyl cellulose carbon of lignocellulosic based materials incorporated manganese oxide for supercapacitor application.
33722623	5	21	theme	carbon	1018:1023	arg1	films					1025:1029	both CMC carbon films	1009:1029	both CMC carbon films	1009:1029	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	2	22	theme	empty	327:331	arg1	bunch					339:343	bamboo (B) and oil palm empty fruit bunch	303:343	bunch	339:343	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	2	23	theme	incipient	378:386	arg1	method					409:414	simple incipient wetness impregnation method	371:414	simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3)	371:496	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	0	24	theme	Porous	0:5	arg1	carbon					31:36	Porous carboxymethyl cellulose carbon	0:36	Porous carboxymethyl cellulose carbon of lignocellulosic based materials	0:71	Porous carboxymethyl cellulose carbon of lignocellulosic based materials incorporated manganese oxide for supercapacitor application.
33722623	6	25	theme	supercapacitor	1265:1278	arg1	application					1280:1290	supercapacitor application	1265:1290	supercapacitor application	1265:1290	Therefore, it can be highlighted that Mn2O3/CMC composite film as prepared from bamboo and oil palm fruit can potentially become the new electrode materials for supercapacitor application.
33722623	2	26	theme	palm	322:325	arg1	bunch					339:343	bamboo (B) and oil palm empty fruit bunch	303:343	bunch	339:343	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	2	27	theme	simple	371:376	arg1	method					409:414	simple incipient wetness impregnation method	371:414	simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3)	371:496	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	4	28	theme	composite	752:760	arg1	films					762:766	composite films	752:766	composite films	752:766	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
33722623	6	29	theme	new	1237:1239	arg1	materials					1251:1259	the new electrode materials	1233:1259	the new electrode materials for supercapacitor application	1233:1290	Therefore, it can be highlighted that Mn2O3/CMC composite film as prepared from bamboo and oil palm fruit can potentially become the new electrode materials for supercapacitor application.
33722623	2	30	theme	oil	318:320	arg1	bunch					339:343	bamboo (B) and oil palm empty fruit bunch	303:343	bunch	339:343	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	2	31	theme	calcination	428:438	arg1	process					440:446	calcination process	428:446	calcination process before incorporation with manganese oxide (Mn2O3)	428:496	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	0	32	theme	cellulose	21:29	arg1	carbon					31:36	Porous carboxymethyl cellulose carbon	0:36	Porous carboxymethyl cellulose carbon of lignocellulosic based materials	0:71	Porous carboxymethyl cellulose carbon of lignocellulosic based materials incorporated manganese oxide for supercapacitor application.
33722623	5	33	theme	mF	968:969	arg1	cm-2					971:974	24.15 mF cm-2	962:974	24.15 mF cm-2	962:974	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	3	34	theme	porous	526:531	arg1	carbon					537:542	porous CMC carbon	526:542	porous CMC carbon whereby CMCB exhibited higher surface area than CMCO	526:595	The carbonization produced porous CMC carbon whereby CMCB exhibited higher surface area than CMCO.
33722623	5	35	theme	stable	1043:1048	arg1	stability					1058:1066	fairly stable cycling stability	1036:1066	fairly stable cycling stability after 1000 charge-discharge cycles	1036:1101	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	1	36	theme	based	231:235	arg1	materials					237:245	lignocellulosic based materials	215:245	lignocellulosic based materials	215:245	The present work developed porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials as supercapacitor electrode.
33722623	0	37	theme	lignocellulosic	41:55	arg1	materials					63:71	lignocellulosic based materials	41:71	lignocellulosic based materials	41:71	Porous carboxymethyl cellulose carbon of lignocellulosic based materials incorporated manganese oxide for supercapacitor application.
33722623	4	38	dep	Mn2O3/CMCB	726:735	arg1	films					762:766	composite films	752:766	composite films	752:766	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
33722623	5	39	theme	composite	863:871	arg1	film					873:876	the Mn2O3/CMCB composite film	848:876	the Mn2O3/CMCB composite film	848:876	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	2	40	theme	Porous	276:281	arg1	films					294:298	Porous CMC carbon films	276:298	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O)	276:347	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	4	41	theme	CMCO	658:661	arg1	50.09 nm					682:689	50.09 nm	682:689	50.09 nm	682:689	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
33722623	4	41	theme	CMCO	658:661	arg1	42.76 nm					695:702	42.76 nm	695:702	42.76 nm	695:702	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
33722623	4	41	theme	CMCO	658:661	arg1	size					641:644	the crystallite size	625:644	the crystallite size of CMCB and CMCO	625:661	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
33722623	5	42	theme	higher	888:893	arg1	performance					911:921	higher electrochemical performance	888:921	higher electrochemical performance	888:921	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	6	43	theme	palm	1199:1202	arg1	fruit					1204:1208	oil palm fruit	1195:1208	oil palm fruit	1195:1208	Therefore, it can be highlighted that Mn2O3/CMC composite film as prepared from bamboo and oil palm fruit can potentially become the new electrode materials for supercapacitor application.
33722623	1	44	from	materials	237:245	arg1	film					205:208	porous carboxymethyl cellulose (CMC) carbon film	161:208	porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials	161:245	The present work developed porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials as supercapacitor electrode.
33722623	0	45	theme	materials	63:71	arg1	carbon					31:36	Porous carboxymethyl cellulose carbon	0:36	Porous carboxymethyl cellulose carbon of lignocellulosic based materials	0:71	Porous carboxymethyl cellulose carbon of lignocellulosic based materials incorporated manganese oxide for supercapacitor application.
33722623	5	46	theme	composite	990:998	arg1	film					1000:1003	Mn2O3/CMCO composite film	979:1003	Mn2O3/CMCO composite film	979:1003	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	1	47	theme	present	138:144	arg1	work					146:149	The present work	134:149	The present work	134:149	The present work developed porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials as supercapacitor electrode.
33722623	0	48	theme	based	57:61	arg1	materials					63:71	lignocellulosic based materials	41:71	lignocellulosic based materials	41:71	Porous carboxymethyl cellulose carbon of lignocellulosic based materials incorporated manganese oxide for supercapacitor application.
33722623	5	49	dep	exhibited	878:886	arg1	cm-2					942:945	31.98 mF cm-2	933:945	31.98 mF cm-2	933:945	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	5	50	theme	cycling	1050:1056	arg1	stability					1058:1066	fairly stable cycling stability	1036:1066	fairly stable cycling stability after 1000 charge-discharge cycles	1036:1101	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	6	51	theme	composite	1152:1160	arg1	film					1162:1165	Mn2O3/CMC composite film	1142:1165	Mn2O3/CMC composite film as prepared from bamboo and oil palm fruit	1142:1208	Therefore, it can be highlighted that Mn2O3/CMC composite film as prepared from bamboo and oil palm fruit can potentially become the new electrode materials for supercapacitor application.
33722623	2	52	with	incorporation	455:467	arg1	oxide					484:488	manganese oxide	474:488	manganese oxide (Mn2O3)	474:496	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	2	52	with	incorporation	455:467	arg1	Mn2O3					491:495	Mn2O3	491:495	Mn2O3	491:495	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	2	53	theme	bunch	339:343	arg1	films					294:298	Porous CMC carbon films	276:298	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O)	276:347	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	3	54	theme	surface	574:580	arg1	area					582:585	higher surface area	567:585	higher surface area	567:585	The carbonization produced porous CMC carbon whereby CMCB exhibited higher surface area than CMCO.
33722623	1	55	theme	supercapacitor	250:263	arg1	electrode					265:273	supercapacitor electrode	250:273	supercapacitor electrode	250:273	The present work developed porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials as supercapacitor electrode.
33722623	6	56	theme	electrode	1241:1249	arg1	materials					1251:1259	the new electrode materials	1233:1259	the new electrode materials for supercapacitor application	1233:1290	Therefore, it can be highlighted that Mn2O3/CMC composite film as prepared from bamboo and oil palm fruit can potentially become the new electrode materials for supercapacitor application.
33722623	5	57	theme	CMC	1014:1016	arg1	films					1025:1029	both CMC carbon films	1009:1029	both CMC carbon films	1009:1029	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	1	58	theme	porous	161:166	arg1	film					205:208	porous carboxymethyl cellulose (CMC) carbon film	161:208	porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials	161:245	The present work developed porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials as supercapacitor electrode.
33722623	6	59	theme	Mn2O3/CMC	1142:1150	arg1	film					1162:1165	Mn2O3/CMC composite film	1142:1165	Mn2O3/CMC composite film as prepared from bamboo and oil palm fruit	1142:1208	Therefore, it can be highlighted that Mn2O3/CMC composite film as prepared from bamboo and oil palm fruit can potentially become the new electrode materials for supercapacitor application.
33722623	0	60	theme	manganese	86:94	arg1	oxide					96:100	manganese oxide	86:100	manganese oxide for supercapacitor application	86:131	Porous carboxymethyl cellulose carbon of lignocellulosic based materials incorporated manganese oxide for supercapacitor application.
33722623	5	61	theme	charge-discharge	1079:1094	arg1	cycles					1096:1101	1000 charge-discharge cycles	1074:1101	1000 charge-discharge cycles	1074:1101	Comparatively, the Mn2O3/CMCB composite film exhibited higher electrochemical performance which was 31.98 mF cm-2 as compared to 24.15 mF cm-2 by Mn2O3/CMCO composite film and both CMC carbon films with fairly stable cycling stability after 1000 charge-discharge cycles.
33722623	2	62	theme	carbon	287:292	arg1	films					294:298	Porous CMC carbon films	276:298	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O)	276:347	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	1	63	theme	lignocellulosic	215:229	arg1	materials					237:245	lignocellulosic based materials	215:245	lignocellulosic based materials	215:245	The present work developed porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials as supercapacitor electrode.
33722623	1	64	theme	carboxymethyl	168:180	arg1	film					205:208	porous carboxymethyl cellulose (CMC) carbon film	161:208	porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials	161:245	The present work developed porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials as supercapacitor electrode.
33722623	2	65	theme	wetness	388:394	arg1	method					409:414	simple incipient wetness impregnation method	371:414	simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3)	371:496	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	4	66	theme	Mn2O3	604:608	arg1	incorporation					610:622	Mn2O3 incorporation	604:622	Mn2O3 incorporation	604:622	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
33722623	2	67	theme	CMC	283:285	arg1	films					294:298	Porous CMC carbon films	276:298	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O)	276:347	Porous CMC carbon films of bamboo (B) and oil palm empty fruit bunch (O) were prepared through simple incipient wetness impregnation method followed by calcination process before incorporation with manganese oxide (Mn2O3).
33722623	1	68	theme	cellulose	182:190	arg1	film					205:208	porous carboxymethyl cellulose (CMC) carbon film	161:208	porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials	161:245	The present work developed porous carboxymethyl cellulose (CMC) carbon film from lignocellulosic based materials as supercapacitor electrode.
33722623	4	69	theme	crystallite	629:639	arg1	50.09 nm					682:689	50.09 nm	682:689	50.09 nm	682:689	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
33722623	4	69	theme	crystallite	629:639	arg1	42.76 nm					695:702	42.76 nm	695:702	42.76 nm	695:702	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
33722623	4	69	theme	crystallite	629:639	arg1	size					641:644	the crystallite size	625:644	the crystallite size of CMCB and CMCO	625:661	After Mn2O3 incorporation, the crystallite size of CMCB and CMCO were calculated as 50.09 nm and 42.76 nm, respectively whereas Mn2O3/CMCB and Mn2O3/CMCO composite films were revealed to be 26.71 nm and 35.60 nm in size, respectively.
34871653	0	0	theme	breast	102:107	arg1	recurrence					116:125	postoperative breast cancer recurrence	88:125	postoperative breast cancer recurrence	88:125	Local delivery of biocompatible lentinan/chitosan composite for prolonged inhibition of postoperative breast cancer recurrence.
34871653	4	1	theme	composite	557:565	arg1	LNT/chitosan					544:555	a sponge-like LNT/chitosan composite	530:565	a sponge-like LNT/chitosan composite (LNT/CS sponge)	530:581	Here, a sponge-like LNT/chitosan composite (LNT/CS sponge) was prepared for efficient local delivery to prevent postoperative BCR.
34871653	4	1	theme	composite	557:565	arg1	sponge					575:580	LNT/CS sponge	568:580	LNT/CS sponge	568:580	Here, a sponge-like LNT/chitosan composite (LNT/CS sponge) was prepared for efficient local delivery to prevent postoperative BCR.
34871653	6	2	theme	mouse	970:974	arg1	model					976:980	a subcutaneous postsurgical recurrence mouse model	931:980	a subcutaneous postsurgical recurrence mouse model	931:980	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	8	3	contain	has	1160:1162	arg2	alternative					1197:1207	a promising alternative	1185:1207	a promising alternative for postsurgical BCR	1185:1228	Therefore, LNT/CS sponge has a great potential as a promising alternative for postsurgical BCR.
34871653	8	3	contain	has	1160:1162	arg2	potential					1172:1180	a great potential	1164:1180	a great potential	1164:1180	Therefore, LNT/CS sponge has a great potential as a promising alternative for postsurgical BCR.
34871653	8	3	contain	has	1160:1162	arg1	sponge					1153:1158	LNT/CS sponge	1146:1158	LNT/CS sponge	1146:1158	Therefore, LNT/CS sponge has a great potential as a promising alternative for postsurgical BCR.
34871653	7	4	theme	Subsequent	983:992	arg1	studies					994:1000	Subsequent studies	983:1000	Subsequent studies	983:1000	Subsequent studies revealed that LNT can restrain the stemness of breast cancer cells, which may account for the long-term inhibition of tumor relapse.
34871653	4	5	theme	postoperative	636:648	arg1	BCR					650:652	postoperative BCR	636:652	postoperative BCR	636:652	Here, a sponge-like LNT/chitosan composite (LNT/CS sponge) was prepared for efficient local delivery to prevent postoperative BCR.
34871653	0	6	theme	postoperative	88:100	arg1	recurrence					116:125	postoperative breast cancer recurrence	88:125	postoperative breast cancer recurrence	88:125	Local delivery of biocompatible lentinan/chitosan composite for prolonged inhibition of postoperative breast cancer recurrence.
34871653	6	7	theme	regrowth	887:894	arg1	suppression					856:866	suppression	856:866	suppression of long-term tumor regrowth with favorable biocompatibility	856:926	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	6	7	theme	regrowth	887:894	arg1	reduction					815:823	significant reduction	803:823	significant reduction of postsurgical recurrence	803:850	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	0	8	theme	recurrence	116:125	arg1	inhibition					74:83	prolonged inhibition	64:83	prolonged inhibition of postoperative breast cancer recurrence	64:125	Local delivery of biocompatible lentinan/chitosan composite for prolonged inhibition of postoperative breast cancer recurrence.
34871653	1	9	dep	researchers	238:248	arg1	enthusiasm					251:260	enthusiasm	251:260	enthusiasm	251:260	Postsurgical localized chemotherapy for breast cancer recurrence (BCR) still faces many problems which dampen researchers' enthusiasm and discounted prognosis.
34871653	1	9	dep	researchers	238:248	arg1	prognosis					277:285	discounted prognosis	266:285	discounted prognosis	266:285	Postsurgical localized chemotherapy for breast cancer recurrence (BCR) still faces many problems which dampen researchers' enthusiasm and discounted prognosis.
34871653	1	9	dep	researchers	238:248	arg1	researchers					238:248	researchers' enthusiasm and discounted prognosis	238:285	researchers' enthusiasm and discounted prognosis	238:285	Postsurgical localized chemotherapy for breast cancer recurrence (BCR) still faces many problems which dampen researchers' enthusiasm and discounted prognosis.
34871653	5	10	theme	LNT	726:728	arg1	porosity					692:699	uniform porosity	684:699	uniform porosity	684:699	The obtained sponges exhibit uniform porosity and sustained release of LNT in vitro and in vivo.
34871653	5	10	theme	LNT	726:728	arg1	release					715:721	sustained release	705:721	sustained release	705:721	The obtained sponges exhibit uniform porosity and sustained release of LNT in vitro and in vivo.
34871653	5	11	theme	obtained	659:666	arg1	sponges					668:674	The obtained sponges	655:674	The obtained sponges	655:674	The obtained sponges exhibit uniform porosity and sustained release of LNT in vitro and in vivo.
34871653	3	12	theme	excellent	393:401	arg1	activity					442:449	excellent biocompatibility and notable antitumor activity	393:449	excellent biocompatibility and notable antitumor activity but rather low bioavailability	393:480	Lentinan (LNT) has excellent biocompatibility and notable antitumor activity but rather low bioavailability after intravenous or oral administration.
34871653	6	13	with	regrowth	887:894	arg1	biocompatibility					911:926	favorable biocompatibility	901:926	favorable biocompatibility	901:926	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	6	14	theme	long-term	871:879	arg1	regrowth					887:894	long-term tumor regrowth	871:894	long-term tumor regrowth with favorable biocompatibility	871:926	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	8	15	theme	great	1166:1170	arg1	potential					1172:1180	a great potential	1164:1180	a great potential	1164:1180	Therefore, LNT/CS sponge has a great potential as a promising alternative for postsurgical BCR.
34871653	8	15	theme	great	1166:1170	arg1	alternative					1197:1207	a promising alternative	1185:1207	a promising alternative for postsurgical BCR	1185:1228	Therefore, LNT/CS sponge has a great potential as a promising alternative for postsurgical BCR.
34871653	5	16	theme	uniform	684:690	arg1	porosity					692:699	uniform porosity	684:699	uniform porosity	684:699	The obtained sponges exhibit uniform porosity and sustained release of LNT in vitro and in vivo.
34871653	7	17	theme	breast	1049:1054	arg1	cells					1063:1067	breast cancer cells	1049:1067	breast cancer cells	1049:1067	Subsequent studies revealed that LNT can restrain the stemness of breast cancer cells, which may account for the long-term inhibition of tumor relapse.
34871653	2	18	theme	controllable	311:322	arg1	toxicities					324:333	controllable toxicities	311:333	controllable toxicities	311:333	Simple strategies with controllable toxicities are expected to address these hurdles.
34871653	3	19	theme	intravenous	488:498	arg1	administration					508:521	intravenous or oral administration	488:521	intravenous or oral administration	488:521	Lentinan (LNT) has excellent biocompatibility and notable antitumor activity but rather low bioavailability after intravenous or oral administration.
34871653	0	20	theme	Local	0:4	arg1	delivery					6:13	Local delivery	0:13	Local delivery of biocompatible lentinan/chitosan composite for prolonged inhibition of postoperative breast cancer recurrence.	0:126	Local delivery of biocompatible lentinan/chitosan composite for prolonged inhibition of postoperative breast cancer recurrence.
34871653	7	21	theme	cells	1063:1067	arg1	stemness					1037:1044	the stemness	1033:1044	the stemness of breast cancer cells, which may account for the long-term inhibition of tumor relapse	1033:1132	Subsequent studies revealed that LNT can restrain the stemness of breast cancer cells, which may account for the long-term inhibition of tumor relapse.
34871653	3	22	theme	notable	424:430	arg1	activity					442:449	excellent biocompatibility and notable antitumor activity	393:449	excellent biocompatibility and notable antitumor activity but rather low bioavailability	393:480	Lentinan (LNT) has excellent biocompatibility and notable antitumor activity but rather low bioavailability after intravenous or oral administration.
34871653	4	23	theme	sponge-like	532:542	arg1	LNT/chitosan					544:555	a sponge-like LNT/chitosan composite	530:565	a sponge-like LNT/chitosan composite (LNT/CS sponge)	530:581	Here, a sponge-like LNT/chitosan composite (LNT/CS sponge) was prepared for efficient local delivery to prevent postoperative BCR.
34871653	4	23	theme	sponge-like	532:542	arg1	sponge					575:580	LNT/CS sponge	568:580	LNT/CS sponge	568:580	Here, a sponge-like LNT/chitosan composite (LNT/CS sponge) was prepared for efficient local delivery to prevent postoperative BCR.
34871653	8	24	theme	postsurgical	1213:1224	arg1	BCR					1226:1228	postsurgical BCR	1213:1228	postsurgical BCR	1213:1228	Therefore, LNT/CS sponge has a great potential as a promising alternative for postsurgical BCR.
34871653	3	25	theme	antitumor	432:440	arg1	activity					442:449	excellent biocompatibility and notable antitumor activity	393:449	excellent biocompatibility and notable antitumor activity but rather low bioavailability	393:480	Lentinan (LNT) has excellent biocompatibility and notable antitumor activity but rather low bioavailability after intravenous or oral administration.
34871653	4	26	theme	local	610:614	arg1	delivery					616:623	efficient local delivery	600:623	efficient local delivery to prevent postoperative BCR	600:652	Here, a sponge-like LNT/chitosan composite (LNT/CS sponge) was prepared for efficient local delivery to prevent postoperative BCR.
34871653	5	27	theme	sustained	705:713	arg1	release					715:721	sustained release	705:721	sustained release	705:721	The obtained sponges exhibit uniform porosity and sustained release of LNT in vitro and in vivo.
34871653	6	28	theme	recurrence	841:850	arg1	suppression					856:866	suppression	856:866	suppression of long-term tumor regrowth with favorable biocompatibility	856:926	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	6	28	theme	recurrence	841:850	arg1	reduction					815:823	significant reduction	803:823	significant reduction of postsurgical recurrence	803:850	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	1	29	theme	many	211:214	arg1	problems					216:223	many problems	211:223	many problems which dampen researchers' enthusiasm and discounted prognosis	211:285	Postsurgical localized chemotherapy for breast cancer recurrence (BCR) still faces many problems which dampen researchers' enthusiasm and discounted prognosis.
34871653	0	30	theme	biocompatible	18:30	arg1	composite					50:58	biocompatible lentinan/chitosan composite	18:58	biocompatible lentinan/chitosan composite	18:58	Local delivery of biocompatible lentinan/chitosan composite for prolonged inhibition of postoperative breast cancer recurrence.
34871653	4	31	theme	efficient	600:608	arg1	delivery					616:623	efficient local delivery	600:623	efficient local delivery to prevent postoperative BCR	600:652	Here, a sponge-like LNT/chitosan composite (LNT/CS sponge) was prepared for efficient local delivery to prevent postoperative BCR.
34871653	6	32	theme	postsurgical	828:839	arg1	recurrence					841:850	postsurgical recurrence	828:850	postsurgical recurrence	828:850	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	6	33	theme	tumor	881:885	arg1	regrowth					887:894	long-term tumor regrowth	871:894	long-term tumor regrowth with favorable biocompatibility	871:926	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	7	34	theme	cancer	1056:1061	arg1	cells					1063:1067	breast cancer cells	1049:1067	breast cancer cells	1049:1067	Subsequent studies revealed that LNT can restrain the stemness of breast cancer cells, which may account for the long-term inhibition of tumor relapse.
34871653	6	35	theme	recurrence	959:968	arg1	model					976:980	a subcutaneous postsurgical recurrence mouse model	931:980	a subcutaneous postsurgical recurrence mouse model	931:980	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	1	36	theme	Postsurgical	128:139	arg1	chemotherapy					151:162	Postsurgical localized chemotherapy	128:162	Postsurgical localized chemotherapy for breast cancer recurrence (BCR)	128:197	Postsurgical localized chemotherapy for breast cancer recurrence (BCR) still faces many problems which dampen researchers' enthusiasm and discounted prognosis.
34871653	0	37	theme	composite	50:58	arg1	delivery					6:13	Local delivery	0:13	Local delivery of biocompatible lentinan/chitosan composite for prolonged inhibition of postoperative breast cancer recurrence.	0:126	Local delivery of biocompatible lentinan/chitosan composite for prolonged inhibition of postoperative breast cancer recurrence.
34871653	3	38	dep	Lentinan	374:381	arg1	LNT					384:386	LNT	384:386	LNT	384:386	Lentinan (LNT) has excellent biocompatibility and notable antitumor activity but rather low bioavailability after intravenous or oral administration.
34871653	6	39	theme	postsurgical	946:957	arg1	model					976:980	a subcutaneous postsurgical recurrence mouse model	931:980	a subcutaneous postsurgical recurrence mouse model	931:980	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	3	40	theme	oral	503:506	arg1	administration					508:521	intravenous or oral administration	488:521	intravenous or oral administration	488:521	Lentinan (LNT) has excellent biocompatibility and notable antitumor activity but rather low bioavailability after intravenous or oral administration.
34871653	0	41	theme	lentinan/chitosan	32:48	arg1	composite					50:58	biocompatible lentinan/chitosan composite	18:58	biocompatible lentinan/chitosan composite	18:58	Local delivery of biocompatible lentinan/chitosan composite for prolonged inhibition of postoperative breast cancer recurrence.
34871653	3	42	theme	low	462:464	arg1	bioavailability					466:480	low bioavailability	462:480	excellent biocompatibility and notable antitumor activity but rather low bioavailability	393:480	Lentinan (LNT) has excellent biocompatibility and notable antitumor activity but rather low bioavailability after intravenous or oral administration.
34871653	6	43	theme	subcutaneous	933:944	arg1	model					976:980	a subcutaneous postsurgical recurrence mouse model	931:980	a subcutaneous postsurgical recurrence mouse model	931:980	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	3	44	theme	biocompatibility	403:418	arg1	activity					442:449	excellent biocompatibility and notable antitumor activity	393:449	excellent biocompatibility and notable antitumor activity but rather low bioavailability	393:480	Lentinan (LNT) has excellent biocompatibility and notable antitumor activity but rather low bioavailability after intravenous or oral administration.
34871653	7	45	theme	long-term	1096:1104	arg1	inhibition					1106:1115	the long-term inhibition	1092:1115	the long-term inhibition of tumor relapse	1092:1132	Subsequent studies revealed that LNT can restrain the stemness of breast cancer cells, which may account for the long-term inhibition of tumor relapse.
34871653	0	46	theme	prolonged	64:72	arg1	inhibition					74:83	prolonged inhibition	64:83	prolonged inhibition of postoperative breast cancer recurrence	64:125	Local delivery of biocompatible lentinan/chitosan composite for prolonged inhibition of postoperative breast cancer recurrence.
34871653	7	47	theme	relapse	1126:1132	arg1	inhibition					1106:1115	the long-term inhibition	1092:1115	the long-term inhibition of tumor relapse	1092:1132	Subsequent studies revealed that LNT can restrain the stemness of breast cancer cells, which may account for the long-term inhibition of tumor relapse.
34871653	1	48	theme	localized	141:149	arg1	chemotherapy					151:162	Postsurgical localized chemotherapy	128:162	Postsurgical localized chemotherapy for breast cancer recurrence (BCR)	128:197	Postsurgical localized chemotherapy for breast cancer recurrence (BCR) still faces many problems which dampen researchers' enthusiasm and discounted prognosis.
34871653	4	49	theme	LNT/CS	568:573	arg1	LNT/chitosan					544:555	a sponge-like LNT/chitosan composite	530:565	a sponge-like LNT/chitosan composite (LNT/CS sponge)	530:581	Here, a sponge-like LNT/chitosan composite (LNT/CS sponge) was prepared for efficient local delivery to prevent postoperative BCR.
34871653	4	49	theme	LNT/CS	568:573	arg1	sponge					575:580	LNT/CS sponge	568:580	LNT/CS sponge	568:580	Here, a sponge-like LNT/chitosan composite (LNT/CS sponge) was prepared for efficient local delivery to prevent postoperative BCR.
34871653	2	50	with	strategies	295:304	arg1	toxicities					324:333	controllable toxicities	311:333	controllable toxicities	311:333	Simple strategies with controllable toxicities are expected to address these hurdles.
34871653	6	51	theme	significant	803:813	arg1	reduction					815:823	significant reduction	803:823	significant reduction of postsurgical recurrence	803:850	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	3	52	contain	has	389:391	arg1	Lentinan					374:381	Lentinan	374:381	Lentinan (LNT)	374:387	Lentinan (LNT) has excellent biocompatibility and notable antitumor activity but rather low bioavailability after intravenous or oral administration.
34871653	3	52	contain	has	389:391	arg2	bioavailability					466:480	low bioavailability	462:480	excellent biocompatibility and notable antitumor activity but rather low bioavailability	393:480	Lentinan (LNT) has excellent biocompatibility and notable antitumor activity but rather low bioavailability after intravenous or oral administration.
34871653	3	52	contain	has	389:391	arg2	activity					442:449	excellent biocompatibility and notable antitumor activity	393:449	excellent biocompatibility and notable antitumor activity but rather low bioavailability	393:480	Lentinan (LNT) has excellent biocompatibility and notable antitumor activity but rather low bioavailability after intravenous or oral administration.
34871653	7	53	theme	tumor	1120:1124	arg1	relapse					1126:1132	tumor relapse	1120:1132	tumor relapse	1120:1132	Subsequent studies revealed that LNT can restrain the stemness of breast cancer cells, which may account for the long-term inhibition of tumor relapse.
34871653	6	54	theme	favorable	901:909	arg1	biocompatibility					911:926	favorable biocompatibility	901:926	favorable biocompatibility	901:926	Furthermore, the sponges were implanted and showed significant reduction of postsurgical recurrence and suppression of long-term tumor regrowth with favorable biocompatibility in a subcutaneous postsurgical recurrence mouse model.
34871653	2	55	theme	Simple	288:293	arg1	strategies					295:304	Simple strategies	288:304	Simple strategies with controllable toxicities	288:333	Simple strategies with controllable toxicities are expected to address these hurdles.
34871653	1	56	theme	breast	168:173	arg1	recurrence					182:191	breast cancer recurrence	168:191	breast cancer recurrence (BCR)	168:197	Postsurgical localized chemotherapy for breast cancer recurrence (BCR) still faces many problems which dampen researchers' enthusiasm and discounted prognosis.
34871653	1	56	theme	breast	168:173	arg1	BCR					194:196	BCR	194:196	BCR	194:196	Postsurgical localized chemotherapy for breast cancer recurrence (BCR) still faces many problems which dampen researchers' enthusiasm and discounted prognosis.
34871653	8	57	theme	LNT/CS	1146:1151	arg1	sponge					1153:1158	LNT/CS sponge	1146:1158	LNT/CS sponge	1146:1158	Therefore, LNT/CS sponge has a great potential as a promising alternative for postsurgical BCR.
34871653	1	58	theme	cancer	175:180	arg1	recurrence					182:191	breast cancer recurrence	168:191	breast cancer recurrence (BCR)	168:197	Postsurgical localized chemotherapy for breast cancer recurrence (BCR) still faces many problems which dampen researchers' enthusiasm and discounted prognosis.
34871653	1	58	theme	cancer	175:180	arg1	BCR					194:196	BCR	194:196	BCR	194:196	Postsurgical localized chemotherapy for breast cancer recurrence (BCR) still faces many problems which dampen researchers' enthusiasm and discounted prognosis.
34871653	1	59	theme	discounted	266:275	arg1	prognosis					277:285	discounted prognosis	266:285	discounted prognosis	266:285	Postsurgical localized chemotherapy for breast cancer recurrence (BCR) still faces many problems which dampen researchers' enthusiasm and discounted prognosis.
34871653	1	59	theme	discounted	266:275	arg1	researchers					238:248	researchers' enthusiasm and discounted prognosis	238:285	researchers' enthusiasm and discounted prognosis	238:285	Postsurgical localized chemotherapy for breast cancer recurrence (BCR) still faces many problems which dampen researchers' enthusiasm and discounted prognosis.
34871653	8	60	theme	promising	1187:1195	arg1	potential					1172:1180	a great potential	1164:1180	a great potential	1164:1180	Therefore, LNT/CS sponge has a great potential as a promising alternative for postsurgical BCR.
34871653	8	60	theme	promising	1187:1195	arg1	alternative					1197:1207	a promising alternative	1185:1207	a promising alternative for postsurgical BCR	1185:1228	Therefore, LNT/CS sponge has a great potential as a promising alternative for postsurgical BCR.
34871653	0	61	theme	cancer	109:114	arg1	recurrence					116:125	postoperative breast cancer recurrence	88:125	postoperative breast cancer recurrence	88:125	Local delivery of biocompatible lentinan/chitosan composite for prolonged inhibition of postoperative breast cancer recurrence.
32070509	2	0	theme	efficient	493:501	arg1	removal					508:514	highly efficient Pb2+ removal	486:514	highly efficient Pb2+ removal	486:514	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	6	1	theme	wastewater	1203:1212	arg1	treatment					1214:1222	wastewater treatment	1203:1222	wastewater treatment	1203:1222	This study offers a new strategy to prepare a promising composite with advanced antibacterial and heavy metal removal properties for wastewater treatment.
32070509	2	2	theme	copper	345:350	arg1	nanoparticles					352:364	sheet-like copper nanoparticles	334:364	sheet-like copper nanoparticles	334:364	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	1	3	theme	@	235:235	arg1	CNC					236:238	Fe-Cu@CNC	230:238	Fe-Cu@CNC	230:238	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	1	3	theme	@	235:235	arg1	nanocrystals					216:227	Fe-Cu alloy decorated cellulose nanocrystals	184:227	Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC)	184:239	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	0	4	theme	antibacterial	70:82	arg1	ability					84:90	strong antibacterial ability	63:90	strong antibacterial ability	63:90	Novel design of Fe-Cu alloy coated cellulose nanocrystals with strong antibacterial ability and efficient Pb2+ removal.
32070509	3	5	contain	had	532:534	arg1	composites					521:530	The composites	517:530	The composites	517:530	The composites had high antibacterial ratios of 95.9 %-99.9 %, because superoxide radicals can cause irreversible damage to the bacteria, eventually leading to apoptosis and bacterial death.
32070509	3	5	contain	had	532:534	arg2	ratios					555:560	high antibacterial ratios	536:560	high antibacterial ratios of 95.9 %-99.9 %	536:577	The composites had high antibacterial ratios of 95.9 %-99.9 %, because superoxide radicals can cause irreversible damage to the bacteria, eventually leading to apoptosis and bacterial death.
32070509	2	6	theme	sheet-like	334:343	arg1	nanoparticles					352:364	sheet-like copper nanoparticles	334:364	sheet-like copper nanoparticles	334:364	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	0	7	theme	efficient	96:104	arg1	removal					111:117	efficient Pb2+ removal	96:117	efficient Pb2+ removal	96:117	Novel design of Fe-Cu alloy coated cellulose nanocrystals with strong antibacterial ability and efficient Pb2+ removal.
32070509	3	8	theme	bacterial	691:699	arg1	death					701:705	bacterial death	691:705	bacterial death	691:705	The composites had high antibacterial ratios of 95.9 %-99.9 %, because superoxide radicals can cause irreversible damage to the bacteria, eventually leading to apoptosis and bacterial death.
32070509	4	9	theme	Pb2+	756:759	arg1	removal					765:771	quick Pb2+ ion removal	750:771	quick Pb2+ ion removal	750:771	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	6	10	theme	new	1090:1092	arg1	strategy					1094:1101	a new strategy	1088:1101	a new strategy to prepare a promising composite with advanced antibacterial and heavy metal removal properties for wastewater treatment	1088:1222	This study offers a new strategy to prepare a promising composite with advanced antibacterial and heavy metal removal properties for wastewater treatment.
32070509	4	11	theme	CNC	729:731	arg1	composite					733:741	the Fe-Cu@CNC composite	719:741	the Fe-Cu@CNC composite	719:741	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	4	11	theme	CNC	729:731	arg1	Meanwhile					708:716	Meanwhile	708:716	Meanwhile	708:716	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	4	12	theme	%	840:840	arg1	removal					823:829	a total removal	815:829	a total removal of 93.98 % after 1 h	815:850	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	4	12	theme	%	840:840	arg1	reusability					867:877	excellent reusability	857:877	excellent reusability (retaining removal efficiency of 80.41 % after six cycles)	857:936	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	4	12	theme	%	840:840	arg1	5 min					808:812	5 min	808:812	5 min	808:812	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	4	13	theme	quick	750:754	arg1	removal					765:771	quick Pb2+ ion removal	750:771	quick Pb2+ ion removal	750:771	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	4	14	theme	%	918:918	arg1	efficiency					898:907	removal efficiency	890:907	removal efficiency of 80.41 %	890:918	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	4	15	theme	@	728:728	arg1	composite					733:741	the Fe-Cu@CNC composite	719:741	the Fe-Cu@CNC composite	719:741	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	4	15	theme	@	728:728	arg1	Meanwhile					708:716	Meanwhile	708:716	Meanwhile	708:716	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	3	16	theme	high	536:539	arg1	ratios					555:560	high antibacterial ratios	536:560	high antibacterial ratios of 95.9 %-99.9 %	536:577	The composites had high antibacterial ratios of 95.9 %-99.9 %, because superoxide radicals can cause irreversible damage to the bacteria, eventually leading to apoptosis and bacterial death.
32070509	0	17	theme	Pb2+	106:109	arg1	removal					111:117	efficient Pb2+ removal	96:117	efficient Pb2+ removal	96:117	Novel design of Fe-Cu alloy coated cellulose nanocrystals with strong antibacterial ability and efficient Pb2+ removal.
32070509	3	18	theme	antibacterial	541:553	arg1	ratios					555:560	high antibacterial ratios	536:560	high antibacterial ratios of 95.9 %-99.9 %	536:577	The composites had high antibacterial ratios of 95.9 %-99.9 %, because superoxide radicals can cause irreversible damage to the bacteria, eventually leading to apoptosis and bacterial death.
32070509	1	19	theme	novel	159:163	arg1	composite					165:173	a novel composite	157:173	a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC)	157:239	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	5	20	theme	adsorption	943:952	arg1	kinetics					954:961	The adsorption kinetics	939:961	The adsorption kinetics	939:961	The adsorption kinetics demonstrated that the adsorption behavior can be described by pseudo-second-order kinetic model (R2>0.99).
32070509	3	21	theme	-99.9	571:575	arg1	%					570:570	%	570:570	%	570:570	The composites had high antibacterial ratios of 95.9 %-99.9 %, because superoxide radicals can cause irreversible damage to the bacteria, eventually leading to apoptosis and bacterial death.
32070509	0	22	theme	Novel	0:4	arg1	design					6:11	Novel design	0:11	Novel design of Fe-Cu alloy	0:26	Novel design of Fe-Cu alloy coated cellulose nanocrystals with strong antibacterial ability and efficient Pb2+ removal.
32070509	1	23	theme	simple	245:250	arg1	reaction					272:279	simple oxidation-reduction reaction	245:279	simple oxidation-reduction reaction	245:279	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	4	24	theme	total	817:821	arg1	removal					823:829	a total removal	815:829	a total removal of 93.98 % after 1 h	815:850	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	2	25	theme	iron	304:307	arg1	NZVI					324:327	NZVI	324:327	NZVI	324:327	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	2	25	theme	iron	304:307	arg1	nanoparticles					309:321	Spherical zero-valent iron nanoparticles	282:321	Spherical zero-valent iron nanoparticles (NZVI)	282:328	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	0	26	theme	Fe-Cu	16:20	arg1	alloy					22:26	Fe-Cu alloy	16:26	Fe-Cu alloy	16:26	Novel design of Fe-Cu alloy coated cellulose nanocrystals with strong antibacterial ability and efficient Pb2+ removal.
32070509	1	27	theme	oxidation-reduction	252:270	arg1	reaction					272:279	simple oxidation-reduction reaction	245:279	simple oxidation-reduction reaction	245:279	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	6	28	theme	metal	1174:1178	arg1	properties					1188:1197	advanced antibacterial and heavy metal removal properties	1141:1197	advanced antibacterial and heavy metal removal properties for wastewater treatment	1141:1222	This study offers a new strategy to prepare a promising composite with advanced antibacterial and heavy metal removal properties for wastewater treatment.
32070509	2	29	theme	zero-valent	292:302	arg1	NZVI					324:327	NZVI	324:327	NZVI	324:327	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	2	29	theme	zero-valent	292:302	arg1	nanoparticles					309:321	Spherical zero-valent iron nanoparticles	282:321	Spherical zero-valent iron nanoparticles (NZVI)	282:328	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	3	30	theme	%	577:577	arg1	ratios					555:560	high antibacterial ratios	536:560	high antibacterial ratios of 95.9 %-99.9 %	536:577	The composites had high antibacterial ratios of 95.9 %-99.9 %, because superoxide radicals can cause irreversible damage to the bacteria, eventually leading to apoptosis and bacterial death.
32070509	6	31	theme	promising	1116:1124	arg1	composite					1126:1134	a promising composite	1114:1134	a promising composite	1114:1134	This study offers a new strategy to prepare a promising composite with advanced antibacterial and heavy metal removal properties for wastewater treatment.
32070509	2	32	theme	Spherical	282:290	arg1	NZVI					324:327	NZVI	324:327	NZVI	324:327	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	2	32	theme	Spherical	282:290	arg1	nanoparticles					309:321	Spherical zero-valent iron nanoparticles	282:321	Spherical zero-valent iron nanoparticles (NZVI)	282:328	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	6	33	theme	antibacterial	1150:1162	arg1	properties					1188:1197	advanced antibacterial and heavy metal removal properties	1141:1197	advanced antibacterial and heavy metal removal properties for wastewater treatment	1141:1222	This study offers a new strategy to prepare a promising composite with advanced antibacterial and heavy metal removal properties for wastewater treatment.
32070509	1	34	theme	Fe-Cu	184:188	arg1	CNC					236:238	Fe-Cu@CNC	230:238	Fe-Cu@CNC	230:238	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	1	34	theme	Fe-Cu	184:188	arg1	nanocrystals					216:227	Fe-Cu alloy decorated cellulose nanocrystals	184:227	Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC)	184:239	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	4	35	theme	removal	890:896	arg1	efficiency					898:907	removal efficiency	890:907	removal efficiency of 80.41 %	890:918	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	5	36	theme	pseudo-second-order	1025:1043	arg1	R2>0.99					1060:1066	R2>0.99	1060:1066	R2>0.99	1060:1066	The adsorption kinetics demonstrated that the adsorption behavior can be described by pseudo-second-order kinetic model (R2>0.99).
32070509	5	36	theme	pseudo-second-order	1025:1043	arg1	model					1053:1057	pseudo-second-order kinetic model	1025:1057	pseudo-second-order kinetic model (R2>0.99)	1025:1067	The adsorption kinetics demonstrated that the adsorption behavior can be described by pseudo-second-order kinetic model (R2>0.99).
32070509	3	37	theme	superoxide	588:597	arg1	radicals					599:606	superoxide radicals	588:606	superoxide radicals	588:606	The composites had high antibacterial ratios of 95.9 %-99.9 %, because superoxide radicals can cause irreversible damage to the bacteria, eventually leading to apoptosis and bacterial death.
32070509	1	38	theme	alloy	190:194	arg1	CNC					236:238	Fe-Cu@CNC	230:238	Fe-Cu@CNC	230:238	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	1	38	theme	alloy	190:194	arg1	nanocrystals					216:227	Fe-Cu alloy decorated cellulose nanocrystals	184:227	Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC)	184:239	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	0	39	theme	alloy	22:26	arg1	design					6:11	Novel design	0:11	Novel design of Fe-Cu alloy	0:26	Novel design of Fe-Cu alloy coated cellulose nanocrystals with strong antibacterial ability and efficient Pb2+ removal.
32070509	5	40	theme	kinetic	1045:1051	arg1	R2>0.99					1060:1066	R2>0.99	1060:1066	R2>0.99	1060:1066	The adsorption kinetics demonstrated that the adsorption behavior can be described by pseudo-second-order kinetic model (R2>0.99).
32070509	5	40	theme	kinetic	1045:1051	arg1	model					1053:1057	pseudo-second-order kinetic model	1025:1057	pseudo-second-order kinetic model (R2>0.99)	1025:1067	The adsorption kinetics demonstrated that the adsorption behavior can be described by pseudo-second-order kinetic model (R2>0.99).
32070509	2	41	theme	generated	417:425	arg1	composite					427:435	the generated composite	413:435	the generated composite	413:435	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	1	42	theme	decorated	196:204	arg1	CNC					236:238	Fe-Cu@CNC	230:238	Fe-Cu@CNC	230:238	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	1	42	theme	decorated	196:204	arg1	nanocrystals					216:227	Fe-Cu alloy decorated cellulose nanocrystals	184:227	Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC)	184:239	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	2	43	theme	antibacterial	457:469	arg1	activities					471:480	excellent antibacterial activities	447:480	excellent antibacterial activities	447:480	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	6	44	theme	removal	1180:1186	arg1	properties					1188:1197	advanced antibacterial and heavy metal removal properties	1141:1197	advanced antibacterial and heavy metal removal properties for wastewater treatment	1141:1222	This study offers a new strategy to prepare a promising composite with advanced antibacterial and heavy metal removal properties for wastewater treatment.
32070509	0	45	theme	cellulose	35:43	arg1	nanocrystals					45:56	cellulose nanocrystals	35:56	cellulose nanocrystals	35:56	Novel design of Fe-Cu alloy coated cellulose nanocrystals with strong antibacterial ability and efficient Pb2+ removal.
32070509	2	46	theme	excellent	447:455	arg1	activities					471:480	excellent antibacterial activities	447:480	excellent antibacterial activities	447:480	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	5	47	theme	adsorption	985:994	arg1	behavior					996:1003	the adsorption behavior	981:1003	the adsorption behavior	981:1003	The adsorption kinetics demonstrated that the adsorption behavior can be described by pseudo-second-order kinetic model (R2>0.99).
32070509	4	48	theme	excellent	857:865	arg1	reusability					867:877	excellent reusability	857:877	excellent reusability (retaining removal efficiency of 80.41 % after six cycles)	857:936	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	6	49	theme	heavy	1168:1172	arg1	properties					1188:1197	advanced antibacterial and heavy metal removal properties	1141:1197	advanced antibacterial and heavy metal removal properties for wastewater treatment	1141:1222	This study offers a new strategy to prepare a promising composite with advanced antibacterial and heavy metal removal properties for wastewater treatment.
32070509	3	50	theme	irreversible	618:629	arg1	damage					631:636	irreversible damage	618:636	irreversible damage to the bacteria	618:652	The composites had high antibacterial ratios of 95.9 %-99.9 %, because superoxide radicals can cause irreversible damage to the bacteria, eventually leading to apoptosis and bacterial death.
32070509	4	51	theme	%	791:791	arg1	removal					793:799	a 70.76 % removal	783:799	a 70.76 % removal	783:799	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	4	52	theme	Fe-Cu	723:727	arg1	composite					733:741	the Fe-Cu@CNC composite	719:741	the Fe-Cu@CNC composite	719:741	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	4	52	theme	Fe-Cu	723:727	arg1	Meanwhile					708:716	Meanwhile	708:716	Meanwhile	708:716	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	3	53	theme	95.9	565:568	arg1	%					570:570	%	570:570	%	570:570	The composites had high antibacterial ratios of 95.9 %-99.9 %, because superoxide radicals can cause irreversible damage to the bacteria, eventually leading to apoptosis and bacterial death.
32070509	1	54	theme	cellulose	206:214	arg1	CNC					236:238	Fe-Cu@CNC	230:238	Fe-Cu@CNC	230:238	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	1	54	theme	cellulose	206:214	arg1	nanocrystals					216:227	Fe-Cu alloy decorated cellulose nanocrystals	184:227	Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC)	184:239	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	4	55	theme	ion	761:763	arg1	removal					765:771	quick Pb2+ ion removal	750:771	quick Pb2+ ion removal	750:771	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	0	56	theme	strong	63:68	arg1	ability					84:90	strong antibacterial ability	63:90	strong antibacterial ability	63:90	Novel design of Fe-Cu alloy coated cellulose nanocrystals with strong antibacterial ability and efficient Pb2+ removal.
32070509	2	57	theme	CNC	396:398	arg1	surface					400:406	the CNC surface	392:406	the CNC surface	392:406	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	4	58	theme	70.76	785:789	arg1	%					791:791	%	791:791	%	791:791	Meanwhile, the Fe-Cu@CNC composite showed quick Pb2+ ion removal, reaching a 70.76 % removal within 5 min, a total removal of 93.98 % after 1 h, and excellent reusability (retaining removal efficiency of 80.41 % after six cycles).
32070509	1	59	theme	facile	132:137	arg1	method					139:144	a facile method	130:144	a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction	130:279	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	2	60	theme	Pb2+	503:506	arg1	removal					508:514	highly efficient Pb2+ removal	486:514	highly efficient Pb2+ removal	486:514	Spherical zero-valent iron nanoparticles (NZVI) and sheet-like copper nanoparticles were serially anchored on the CNC surface, and the generated composite exhibited excellent antibacterial activities and highly efficient Pb2+ removal.
32070509	6	61	theme	advanced	1141:1148	arg1	properties					1188:1197	advanced antibacterial and heavy metal removal properties	1141:1197	advanced antibacterial and heavy metal removal properties for wastewater treatment	1141:1222	This study offers a new strategy to prepare a promising composite with advanced antibacterial and heavy metal removal properties for wastewater treatment.
32070509	1	62	theme	Fe-Cu	230:234	arg1	CNC					236:238	Fe-Cu@CNC	230:238	Fe-Cu@CNC	230:238	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32070509	1	62	theme	Fe-Cu	230:234	arg1	nanocrystals					216:227	Fe-Cu alloy decorated cellulose nanocrystals	184:227	Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC)	184:239	We report a facile method to prepare a novel composite based on Fe-Cu alloy decorated cellulose nanocrystals (Fe-Cu@CNC) via simple oxidation-reduction reaction.
32380577	7	0	theme	bile	1040:1043	arg1	excretion					1050:1058	Fecal bile acid excretion	1034:1058	Fecal bile acid excretion	1034:1058	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	7	1	theme	cholic	1157:1162	arg1	differences					1127:1137	significant compositional differences	1101:1137	significant compositional differences	1101:1137	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	7	1	theme	cholic	1157:1162	arg1	excretion					1200:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	0	2	theme	Resistance	102:111	arg1	Development					67:77	the Development	63:77	the Development of Obesity and Insulin Resistance in Mice Fed a Western-Type Diet	63:143	Long-Term β-galacto-oligosaccharides Supplementation Decreases the Development of Obesity and Insulin Resistance in Mice Fed a Western-Type Diet.
32380577	4	3	theme	w/w	521:523	arg1	β-GOS					511:515	β-GOS	511:515	β-GOS (7% w/w, 15 weeks)	511:534	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	3	theme	w/w	521:523	arg1	%					519:519	7% w/w	518:523	7% w/w	518:523	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	7	4	theme	acid	1045:1048	arg1	excretion					1050:1058	Fecal bile acid excretion	1034:1058	Fecal bile acid excretion	1034:1058	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	8	5	theme	Substantial	1250:1260	arg1	changes					1262:1268	Substantial changes	1250:1268	Substantial changes	1250:1268	Substantial changes in microbiota composition, conceivably beneficial for metabolic health, occurred upon GOS feeding.
32380577	9	6	theme	weight	1437:1442	arg1	gain					1444:1447	body weight gain	1432:1447	body weight gain	1432:1447	CONCLUSION GOS supplementation to a Western-type diet improves body weight gain, dyslipidemia, and insulin sensitivity, supporting a therapeutic potential of GOS for individuals at risk of developing metabolic syndrome.
32380577	4	7	theme	glucose	555:561	arg1	tolerance					575:583	glucose and insulin tolerance	555:583	tolerance	575:583	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	7	theme	glucose	555:561	arg1	composition					542:552	body composition	537:552	body composition	537:552	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	7	8	theme	significant	1101:1111	arg1	differences					1127:1137	significant compositional differences	1101:1137	significant compositional differences	1101:1137	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	7	8	theme	significant	1101:1111	arg1	excretion					1200:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	9	9	theme	metabolic	1569:1577	arg1	syndrome					1579:1586	metabolic syndrome	1569:1586	metabolic syndrome	1569:1586	CONCLUSION GOS supplementation to a Western-type diet improves body weight gain, dyslipidemia, and insulin sensitivity, supporting a therapeutic potential of GOS for individuals at risk of developing metabolic syndrome.
32380577	1	10	dep	SCOPE	146:150	arg1	microbiota					160:169	The gut microbiota	152:169	SCOPE The gut microbiota	146:169	SCOPE The gut microbiota might critically modify metabolic disease development.
32380577	7	11	theme	compositional	1113:1125	arg1	differences					1127:1137	significant compositional differences	1101:1137	significant compositional differences	1101:1137	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	7	11	theme	compositional	1113:1125	arg1	excretion					1200:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	7	12	theme	Fecal	1034:1038	arg1	excretion					1050:1058	Fecal bile acid excretion	1034:1058	Fecal bile acid excretion	1034:1058	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	2	13	theme	metabolic	325:333	arg1	health					335:340	metabolic health	325:340	metabolic health	325:340	Dietary fibers such as galacto-oligosaccharides (GOS) presumably stimulate bacteria beneficial for metabolic health.
32380577	4	14	theme	insulin	567:573	arg1	tolerance					575:583	glucose and insulin tolerance	555:583	tolerance	575:583	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	14	theme	insulin	567:573	arg1	composition					542:552	body composition	537:552	body composition	537:552	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	0	15	theme	Western-Type	127:138	arg1	Diet					140:143	a Western-Type Diet	125:143	a Western-Type Diet	125:143	Long-Term β-galacto-oligosaccharides Supplementation Decreases the Development of Obesity and Insulin Resistance in Mice Fed a Western-Type Diet.
32380577	7	16	theme	α-muricholic	1165:1176	arg1	differences					1127:1137	significant compositional differences	1101:1137	significant compositional differences	1101:1137	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	7	16	theme	α-muricholic	1165:1176	arg1	excretion					1200:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	9	17	theme	CONCLUSION	1369:1378	arg1	supplementation					1384:1398	CONCLUSION GOS supplementation	1369:1398	CONCLUSION GOS supplementation to a Western-type diet	1369:1421	CONCLUSION GOS supplementation to a Western-type diet improves body weight gain, dyslipidemia, and insulin sensitivity, supporting a therapeutic potential of GOS for individuals at risk of developing metabolic syndrome.
32380577	6	18	theme	higher	987:992	arg1	p < 0.01					1023:1030	p < 0.01	1023:1030	p < 0.01	1023:1030	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	18	theme	higher	987:992	arg1	expression					1011:1020	higher intestinal GLP-1 expression	987:1020	higher intestinal GLP-1 expression (p < 0.01)	987:1031	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	19	theme	GLP-1	1005:1009	arg1	p < 0.01					1023:1030	p < 0.01	1023:1030	p < 0.01	1023:1030	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	19	theme	GLP-1	1005:1009	arg1	expression					1011:1020	higher intestinal GLP-1 expression	987:1020	higher intestinal GLP-1 expression (p < 0.01)	987:1031	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	5	20	theme	epididymal	713:722	arg1	p < 0.01					786:793	p < 0.01	786:793	p < 0.01	786:793	GOS reduces body weight gain (p < 0.01), accumulation of epididymal (p < 0.05), perirenal (p < 0.01) fat, and insulin resistance (p < 0.01).
32380577	5	20	theme	epididymal	713:722	arg1	resistance					774:783	insulin resistance	766:783	insulin resistance (p < 0.01)	766:794	GOS reduces body weight gain (p < 0.01), accumulation of epididymal (p < 0.05), perirenal (p < 0.01) fat, and insulin resistance (p < 0.01).
32380577	5	20	theme	epididymal	713:722	arg1	p < 0.01					686:693	p < 0.01	686:693	p < 0.01	686:693	GOS reduces body weight gain (p < 0.01), accumulation of epididymal (p < 0.05), perirenal (p < 0.01) fat, and insulin resistance (p < 0.01).
32380577	5	20	theme	epididymal	713:722	arg1	accumulation					697:708	accumulation	697:708	accumulation of epididymal (p < 0.05), perirenal (p < 0.01) fat	697:759	GOS reduces body weight gain (p < 0.01), accumulation of epididymal (p < 0.05), perirenal (p < 0.01) fat, and insulin resistance (p < 0.01).
32380577	5	20	theme	epididymal	713:722	arg1	gain					680:683	body weight gain	668:683	body weight gain (p < 0.01)	668:694	GOS reduces body weight gain (p < 0.01), accumulation of epididymal (p < 0.05), perirenal (p < 0.01) fat, and insulin resistance (p < 0.01).
32380577	0	21	from	Development	67:77	arg1	Mice					116:119	Mice	116:119	Mice Fed a Western-Type Diet	116:143	Long-Term β-galacto-oligosaccharides Supplementation Decreases the Development of Obesity and Insulin Resistance in Mice Fed a Western-Type Diet.
32380577	8	22	from	changes	1262:1268	arg1	composition					1284:1294	microbiota composition	1273:1294	microbiota composition	1273:1294	Substantial changes in microbiota composition, conceivably beneficial for metabolic health, occurred upon GOS feeding.
32380577	2	23	theme	beneficial	310:319	arg1	bacteria					301:308	bacteria	301:308	bacteria beneficial for metabolic health	301:340	Dietary fibers such as galacto-oligosaccharides (GOS) presumably stimulate bacteria beneficial for metabolic health.
32380577	1	24	theme	metabolic	195:203	arg1	development					213:223	metabolic disease development	195:223	metabolic disease development	195:223	SCOPE The gut microbiota might critically modify metabolic disease development.
32380577	0	25	theme	β-galacto-oligosaccharides	10:35	arg1	Supplementation					37:51	Long-Term β-galacto-oligosaccharides Supplementation	0:51	Long-Term β-galacto-oligosaccharides Supplementation	0:51	Long-Term β-galacto-oligosaccharides Supplementation Decreases the Development of Obesity and Insulin Resistance in Mice Fed a Western-Type Diet.
32380577	6	26	theme	lower	815:819	arg1	cholesterol					828:838	lower plasma cholesterol	815:838	lower plasma cholesterol (p < 0.05)	815:849	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	26	theme	lower	815:819	arg1	p < 0.05					841:848	p < 0.05	841:848	p < 0.05	841:848	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	7	27	dep	lower	1063:1067	arg1	p < 0.01					1070:1077	p < 0.01	1070:1077	p < 0.01	1070:1077	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	9	28	theme	therapeutic	1502:1512	arg1	potential					1514:1522	a therapeutic potential	1500:1522	a therapeutic potential of GOS for individuals at risk of developing metabolic syndrome	1500:1586	CONCLUSION GOS supplementation to a Western-type diet improves body weight gain, dyslipidemia, and insulin sensitivity, supporting a therapeutic potential of GOS for individuals at risk of developing metabolic syndrome.
32380577	8	29	theme	beneficial	1309:1318	arg1	changes					1262:1268	Substantial changes	1250:1268	Substantial changes	1250:1268	Substantial changes in microbiota composition, conceivably beneficial for metabolic health, occurred upon GOS feeding.
32380577	7	30	theme	deoxycholic	1183:1193	arg1	differences					1127:1137	significant compositional differences	1101:1137	significant compositional differences	1101:1137	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	7	30	theme	deoxycholic	1183:1193	arg1	excretion					1200:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	1	31	theme	disease	205:211	arg1	development					213:223	metabolic disease development	195:223	metabolic disease development	195:223	SCOPE The gut microbiota might critically modify metabolic disease development.
32380577	0	32	theme	Long-Term	0:8	arg1	Supplementation					37:51	Long-Term β-galacto-oligosaccharides Supplementation	0:51	Long-Term β-galacto-oligosaccharides Supplementation	0:51	Long-Term β-galacto-oligosaccharides Supplementation Decreases the Development of Obesity and Insulin Resistance in Mice Fed a Western-Type Diet.
32380577	4	33	theme	body	537:540	arg1	tolerance					575:583	glucose and insulin tolerance	555:583	tolerance	575:583	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	33	theme	body	537:540	arg1	kinetics					606:613	fat kinetics	602:613	fat kinetics	602:613	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	33	theme	body	537:540	arg1	composition					542:552	body composition	537:552	body composition	537:552	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	33	theme	body	537:540	arg1	β-GOS					511:515	β-GOS	511:515	β-GOS (7% w/w, 15 weeks)	511:534	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	33	theme	body	537:540	arg1	profiles					592:599	lipid profiles	586:599	lipid profiles	586:599	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	33	theme	body	537:540	arg1	composition					630:640	microbiota composition	619:640	microbiota composition	619:640	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	9	34	from	risk	1550:1553	arg1	individuals					1535:1545	individuals	1535:1545	individuals at risk of developing metabolic syndrome	1535:1586	CONCLUSION GOS supplementation to a Western-type diet improves body weight gain, dyslipidemia, and insulin sensitivity, supporting a therapeutic potential of GOS for individuals at risk of developing metabolic syndrome.
32380577	6	35	theme	fat	909:911	arg1	p < 0.01					925:932	p < 0.01	925:932	p < 0.01	925:932	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	35	theme	fat	909:911	arg1	absorption					913:922	lower intestinal fat absorption	892:922	lower intestinal fat absorption (p < 0.01)	892:933	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	9	36	theme	GOS	1380:1382	arg1	supplementation					1384:1398	CONCLUSION GOS supplementation	1369:1398	CONCLUSION GOS supplementation to a Western-type diet	1369:1421	CONCLUSION GOS supplementation to a Western-type diet improves body weight gain, dyslipidemia, and insulin sensitivity, supporting a therapeutic potential of GOS for individuals at risk of developing metabolic syndrome.
32380577	8	37	theme	metabolic	1324:1332	arg1	health					1334:1339	metabolic health	1324:1339	metabolic health	1324:1339	Substantial changes in microbiota composition, conceivably beneficial for metabolic health, occurred upon GOS feeding.
32380577	7	38	theme	hyodeoxycholic	1219:1232	arg1	acid					1234:1237	hyodeoxycholic acid	1219:1237	hyodeoxycholic acid	1219:1237	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	5	39	theme	insulin	766:772	arg1	p < 0.01					786:793	p < 0.01	786:793	p < 0.01	786:793	GOS reduces body weight gain (p < 0.01), accumulation of epididymal (p < 0.05), perirenal (p < 0.01) fat, and insulin resistance (p < 0.01).
32380577	5	39	theme	insulin	766:772	arg1	resistance					774:783	insulin resistance	766:783	insulin resistance (p < 0.01)	766:794	GOS reduces body weight gain (p < 0.01), accumulation of epididymal (p < 0.05), perirenal (p < 0.01) fat, and insulin resistance (p < 0.01).
32380577	6	40	theme	intestinal	898:907	arg1	p < 0.01					925:932	p < 0.01	925:932	p < 0.01	925:932	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	40	theme	intestinal	898:907	arg1	absorption					913:922	lower intestinal fat absorption	892:922	lower intestinal fat absorption (p < 0.01)	892:933	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	4	41	theme	C57BL/6	481:487	arg1	feeding					472:478	Western-type diet feeding	454:478	Western-type diet feeding (C57BL/6 mice)	454:493	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	41	theme	C57BL/6	481:487	arg1	mice					489:492	C57BL/6 mice	481:492	C57BL/6 mice	481:492	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	42	theme	fat	602:604	arg1	composition					542:552	body composition	537:552	body composition	537:552	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	42	theme	fat	602:604	arg1	kinetics					606:613	fat kinetics	602:613	fat kinetics	602:613	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	6	43	theme	lower	892:896	arg1	p < 0.01					925:932	p < 0.01	925:932	p < 0.01	925:932	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	43	theme	lower	892:896	arg1	absorption					913:922	lower intestinal fat absorption	892:922	lower intestinal fat absorption (p < 0.01)	892:933	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	7	44	theme	GOS-fed	1083:1089	arg1	mice					1091:1094	GOS-fed mice	1083:1094	GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion	1083:1208	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	7	45	with	mice	1091:1094	arg1	differences					1127:1137	significant compositional differences	1101:1137	significant compositional differences	1101:1137	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	7	45	with	mice	1091:1094	arg1	excretion					1200:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	4	46	theme	microbiota	619:628	arg1	composition					542:552	body composition	537:552	body composition	537:552	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	46	theme	microbiota	619:628	arg1	composition					630:640	microbiota composition	619:640	microbiota composition	619:640	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	6	47	theme	sterol	955:960	arg1	p < 0.05					973:980	p < 0.05	973:980	p < 0.05	973:980	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	47	theme	sterol	955:960	arg1	excretion					962:970	more fecal neutral sterol excretion	936:970	more fecal neutral sterol excretion (p < 0.05)	936:981	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	48	theme	GOS-fed	797:803	arg1	mice					805:808	GOS-fed mice	797:808	GOS-fed mice	797:808	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	9	49	theme	body	1432:1435	arg1	gain					1444:1447	body weight gain	1432:1447	body weight gain	1432:1447	CONCLUSION GOS supplementation to a Western-type diet improves body weight gain, dyslipidemia, and insulin sensitivity, supporting a therapeutic potential of GOS for individuals at risk of developing metabolic syndrome.
32380577	0	50	theme	Obesity	82:88	arg1	Development					67:77	the Development	63:77	the Development of Obesity and Insulin Resistance in Mice Fed a Western-Type Diet	63:143	Long-Term β-galacto-oligosaccharides Supplementation Decreases the Development of Obesity and Insulin Resistance in Mice Fed a Western-Type Diet.
32380577	4	51	dep	%	519:519	arg1	weeks					529:533	15 weeks	526:533	15 weeks	526:533	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	8	52	theme	microbiota	1273:1282	arg1	composition					1284:1294	microbiota composition	1273:1294	microbiota composition	1273:1294	Substantial changes in microbiota composition, conceivably beneficial for metabolic health, occurred upon GOS feeding.
32380577	7	53	theme	decreased	1147:1155	arg1	differences					1127:1137	significant compositional differences	1101:1137	significant compositional differences	1101:1137	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	7	53	theme	decreased	1147:1155	arg1	excretion					1200:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	6	54	theme	plasma	821:826	arg1	cholesterol					828:838	lower plasma cholesterol	815:838	lower plasma cholesterol (p < 0.05)	815:849	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	54	theme	plasma	821:826	arg1	p < 0.05					841:848	p < 0.05	841:848	p < 0.05	841:848	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	7	55	theme	acid	1195:1198	arg1	differences					1127:1137	significant compositional differences	1101:1137	significant compositional differences	1101:1137	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	7	55	theme	acid	1195:1198	arg1	excretion					1200:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	decreased cholic, α-muricholic, and deoxycholic acid excretion	1147:1208	Fecal bile acid excretion is lower (p < 0.01) in GOS-fed mice with significant compositional differences, namely decreased cholic, α-muricholic, and deoxycholic acid excretion, whereas hyodeoxycholic acid increased.
32380577	6	56	theme	low-density	866:876	arg1	lipoproteins					878:889	low-density lipoproteins	866:889	low-density lipoproteins	866:889	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	5	57	dep	epididymal	713:722	arg1	fat					757:759	fat	757:759	fat	757:759	GOS reduces body weight gain (p < 0.01), accumulation of epididymal (p < 0.05), perirenal (p < 0.01) fat, and insulin resistance (p < 0.01).
32380577	4	58	theme	Western-type	454:465	arg1	feeding					472:478	Western-type diet feeding	454:478	Western-type diet feeding (C57BL/6 mice)	454:493	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	58	theme	Western-type	454:465	arg1	mice					489:492	C57BL/6 mice	481:492	C57BL/6 mice	481:492	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	5	59	theme	body	668:671	arg1	p < 0.01					686:693	p < 0.01	686:693	p < 0.01	686:693	GOS reduces body weight gain (p < 0.01), accumulation of epididymal (p < 0.05), perirenal (p < 0.01) fat, and insulin resistance (p < 0.01).
32380577	5	59	theme	body	668:671	arg1	gain					680:683	body weight gain	668:683	body weight gain (p < 0.01)	668:694	GOS reduces body weight gain (p < 0.01), accumulation of epididymal (p < 0.05), perirenal (p < 0.01) fat, and insulin resistance (p < 0.01).
32380577	3	60	from	impact	367:372	arg1	obesity					384:390	obesity	384:390	obesity	384:390	This study assesses the impact of GOS on obesity, glucose, and lipid metabolism.
32380577	3	60	from	impact	367:372	arg1	metabolism					412:421	lipid metabolism	406:421	lipid metabolism	406:421	This study assesses the impact of GOS on obesity, glucose, and lipid metabolism.
32380577	3	60	from	impact	367:372	arg1	glucose					393:399	glucose	393:399	glucose	393:399	This study assesses the impact of GOS on obesity, glucose, and lipid metabolism.
32380577	9	61	theme	GOS	1527:1529	arg1	potential					1514:1522	a therapeutic potential	1500:1522	a therapeutic potential of GOS for individuals at risk of developing metabolic syndrome	1500:1586	CONCLUSION GOS supplementation to a Western-type diet improves body weight gain, dyslipidemia, and insulin sensitivity, supporting a therapeutic potential of GOS for individuals at risk of developing metabolic syndrome.
32380577	4	62	theme	lipid	586:590	arg1	composition					542:552	body composition	537:552	body composition	537:552	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	62	theme	lipid	586:590	arg1	profiles					592:599	lipid profiles	586:599	lipid profiles	586:599	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	5	63	theme	weight	673:678	arg1	p < 0.01					686:693	p < 0.01	686:693	p < 0.01	686:693	GOS reduces body weight gain (p < 0.01), accumulation of epididymal (p < 0.05), perirenal (p < 0.01) fat, and insulin resistance (p < 0.01).
32380577	5	63	theme	weight	673:678	arg1	gain					680:683	body weight gain	668:683	body weight gain (p < 0.01)	668:694	GOS reduces body weight gain (p < 0.01), accumulation of epididymal (p < 0.05), perirenal (p < 0.01) fat, and insulin resistance (p < 0.01).
32380577	2	64	theme	Dietary	226:232	arg1	fibers					234:239	Dietary fibers	226:239	Dietary fibers such as galacto-oligosaccharides (GOS)	226:278	Dietary fibers such as galacto-oligosaccharides (GOS) presumably stimulate bacteria beneficial for metabolic health.
32380577	2	64	theme	Dietary	226:232	arg1	galacto-oligosaccharides					249:272	galacto-oligosaccharides	249:272	galacto-oligosaccharides (GOS)	249:278	Dietary fibers such as galacto-oligosaccharides (GOS) presumably stimulate bacteria beneficial for metabolic health.
32380577	8	65	theme	GOS	1356:1358	arg1	feeding					1360:1366	GOS feeding	1356:1366	GOS feeding	1356:1366	Substantial changes in microbiota composition, conceivably beneficial for metabolic health, occurred upon GOS feeding.
32380577	6	66	contain	have	810:813	arg2	expression					1011:1020	higher intestinal GLP-1 expression	987:1020	higher intestinal GLP-1 expression (p < 0.01)	987:1031	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	66	contain	have	810:813	arg2	cholesterol					828:838	lower plasma cholesterol	815:838	lower plasma cholesterol (p < 0.05)	815:849	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	66	contain	have	810:813	arg2	p < 0.01					1023:1030	p < 0.01	1023:1030	p < 0.01	1023:1030	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	66	contain	have	810:813	arg2	p < 0.05					841:848	p < 0.05	841:848	p < 0.05	841:848	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	66	contain	have	810:813	arg2	p < 0.01					925:932	p < 0.01	925:932	p < 0.01	925:932	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	66	contain	have	810:813	arg2	absorption					913:922	lower intestinal fat absorption	892:922	lower intestinal fat absorption (p < 0.01)	892:933	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	66	contain	have	810:813	arg2	excretion					962:970	more fecal neutral sterol excretion	936:970	more fecal neutral sterol excretion (p < 0.05)	936:981	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	66	contain	have	810:813	arg1	mice					805:808	GOS-fed mice	797:808	GOS-fed mice	797:808	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	66	contain	have	810:813	arg2	p < 0.05					973:980	p < 0.05	973:980	p < 0.05	973:980	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	67	theme	neutral	947:953	arg1	p < 0.05					973:980	p < 0.05	973:980	p < 0.05	973:980	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	67	theme	neutral	947:953	arg1	excretion					962:970	more fecal neutral sterol excretion	936:970	more fecal neutral sterol excretion (p < 0.05)	936:981	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	0	68	theme	Insulin	94:100	arg1	Resistance					102:111	Insulin Resistance	94:111	Insulin Resistance	94:111	Long-Term β-galacto-oligosaccharides Supplementation Decreases the Development of Obesity and Insulin Resistance in Mice Fed a Western-Type Diet.
32380577	4	69	theme	diet	467:470	arg1	feeding					472:478	Western-type diet feeding	454:478	Western-type diet feeding (C57BL/6 mice)	454:493	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	4	69	theme	diet	467:470	arg1	mice					489:492	C57BL/6 mice	481:492	C57BL/6 mice	481:492	METHODS AND RESULTS Following Western-type diet feeding (C57BL/6 mice) with or without β-GOS (7% w/w, 15 weeks), body composition, glucose and insulin tolerance, lipid profiles, fat kinetics and microbiota composition are analyzed.
32380577	9	70	theme	Western-type	1405:1416	arg1	diet					1418:1421	a Western-type diet	1403:1421	a Western-type diet	1403:1421	CONCLUSION GOS supplementation to a Western-type diet improves body weight gain, dyslipidemia, and insulin sensitivity, supporting a therapeutic potential of GOS for individuals at risk of developing metabolic syndrome.
32380577	1	71	theme	gut	156:158	arg1	microbiota					160:169	The gut microbiota	152:169	SCOPE The gut microbiota	146:169	SCOPE The gut microbiota might critically modify metabolic disease development.
32380577	6	72	theme	intestinal	994:1003	arg1	p < 0.01					1023:1030	p < 0.01	1023:1030	p < 0.01	1023:1030	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	72	theme	intestinal	994:1003	arg1	expression					1011:1020	higher intestinal GLP-1 expression	987:1020	higher intestinal GLP-1 expression (p < 0.01)	987:1031	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	73	theme	fecal	941:945	arg1	p < 0.05					973:980	p < 0.05	973:980	p < 0.05	973:980	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	73	theme	fecal	941:945	arg1	excretion					962:970	more fecal neutral sterol excretion	936:970	more fecal neutral sterol excretion (p < 0.05)	936:981	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	3	74	theme	GOS	377:379	arg1	impact					367:372	the impact	363:372	the impact of GOS on obesity, glucose, and lipid metabolism	363:421	This study assesses the impact of GOS on obesity, glucose, and lipid metabolism.
32380577	9	75	theme	insulin	1468:1474	arg1	sensitivity					1476:1486	insulin sensitivity	1468:1486	insulin sensitivity	1468:1486	CONCLUSION GOS supplementation to a Western-type diet improves body weight gain, dyslipidemia, and insulin sensitivity, supporting a therapeutic potential of GOS for individuals at risk of developing metabolic syndrome.
32380577	3	76	theme	lipid	406:410	arg1	metabolism					412:421	lipid metabolism	406:421	lipid metabolism	406:421	This study assesses the impact of GOS on obesity, glucose, and lipid metabolism.
32380577	6	77	theme	more	936:939	arg1	p < 0.05					973:980	p < 0.05	973:980	p < 0.05	973:980	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
32380577	6	77	theme	more	936:939	arg1	excretion					962:970	more fecal neutral sterol excretion	936:970	more fecal neutral sterol excretion (p < 0.05)	936:981	GOS-fed mice have lower plasma cholesterol (p < 0.05), mainly within low-density lipoproteins, lower intestinal fat absorption (p < 0.01), more fecal neutral sterol excretion (p < 0.05) and higher intestinal GLP-1 expression (p < 0.01).
33034328	0	0	theme	aggregates	104:113	arg1	construction					83:94	the construction	79:94	the construction of hMSC aggregates	79:113	PLGA/chitosan-heparin composite microparticles prepared with microfluidics for the construction of hMSC aggregates.
33034328	7	1	theme	hMSC	1287:1290	arg1	aggregates					1292:1301	hMSC aggregates	1287:1301	hMSC aggregates incorporating P/C-h microparticles	1287:1336	Furthermore, the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles were also enhanced.
33034328	3	2	theme	microfluidic	531:542	arg1	technology					544:553	the double emulsion and microfluidic technology	507:553	technology	544:553	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	8	3	theme	droplet	1421:1427	arg1	technique					1442:1450	the droplet microfluidic technique	1417:1450	the droplet microfluidic technique	1417:1450	In summary, the P/C-h composite microparticles prepared by the droplet microfluidic technique support the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy.
33034328	0	4	theme	hMSC	99:102	arg1	aggregates					104:113	hMSC aggregates	99:113	hMSC aggregates	99:113	PLGA/chitosan-heparin composite microparticles prepared with microfluidics for the construction of hMSC aggregates.
33034328	5	5	theme	C-h	916:918	arg1	complex					920:926	the C-h complex	912:926	the C-h complex	912:926	When the mass ratio of PLGA to the C-h complex was optimized to 2 : 1, the pH of the leach liquor of P/C-h microparticles remained neutral.
33034328	6	6	theme	burst	1098:1102	arg1	release					1104:1110	the initial burst release	1086:1110	the initial burst release (loaded FGF-2 and VEGF)	1086:1134	Compared with those of PLGA microparticles, the cytotoxicity and the initial burst release (loaded FGF-2 and VEGF) were both significantly reduced in P/C-h microparticles.
33034328	8	7	theme	microfluidic	1429:1440	arg1	technique					1442:1450	the droplet microfluidic technique	1417:1450	the droplet microfluidic technique	1417:1450	In summary, the P/C-h composite microparticles prepared by the droplet microfluidic technique support the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy.
33034328	5	8	theme	liquor	972:977	arg1	pH					956:957	the pH	952:957	the pH of the leach liquor of P/C-h microparticles	952:1001	When the mass ratio of PLGA to the C-h complex was optimized to 2 : 1, the pH of the leach liquor of P/C-h microparticles remained neutral.
33034328	8	9	theme	composite	1380:1388	arg1	microparticles					1390:1403	the P/C-h composite microparticles	1370:1403	the P/C-h composite microparticles prepared by the droplet microfluidic technique	1370:1450	In summary, the P/C-h composite microparticles prepared by the droplet microfluidic technique support the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy.
33034328	4	10	theme	encapsulated	795:806	arg1	complex					812:818	the PLGA encapsulated C-h complex	786:818	the PLGA encapsulated C-h complex	786:818	The P/C-h microparticles were highly monodispersed with a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates.
33034328	8	11	theme	aggregates	1518:1527	arg1	profile					1498:1504	the optimal biological and functional profile	1460:1504	the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy	1460:1596	In summary, the P/C-h composite microparticles prepared by the droplet microfluidic technique support the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy.
33034328	4	12	theme	PLGA	790:793	arg1	complex					812:818	the PLGA encapsulated C-h complex	786:818	the PLGA encapsulated C-h complex	786:818	The P/C-h microparticles were highly monodispersed with a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates.
33034328	7	13	theme	stemness	1220:1227	arg1	abilities					1265:1273	the survival, stemness, as well as secretion and migration abilities	1206:1273	the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles	1206:1336	Furthermore, the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles were also enhanced.
33034328	2	14	theme	degradation	297:307	arg1	products					309:316	the acidic degradation products	286:316	the acidic degradation products	286:316	However, the acidic degradation products and burst release of PLGA microparticles still need to be ameliorated.
33034328	3	15	theme	double	511:516	arg1	emulsion					518:525	the double emulsion and microfluidic technology	507:553	emulsion	518:525	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	6	16	theme	loaded	1113:1118	arg1	FGF-2					1120:1124	FGF-2	1120:1124	FGF-2	1120:1124	Compared with those of PLGA microparticles, the cytotoxicity and the initial burst release (loaded FGF-2 and VEGF) were both significantly reduced in P/C-h microparticles.
33034328	4	17	theme	aggregates	869:878	arg1	fabrication					849:859	the fabrication	845:859	the fabrication of hMSC aggregates	845:878	The P/C-h microparticles were highly monodispersed with a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates.
33034328	7	18	theme	cells	1278:1282	arg1	abilities					1265:1273	the survival, stemness, as well as secretion and migration abilities	1206:1273	the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles	1206:1336	Furthermore, the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles were also enhanced.
33034328	2	19	theme	acidic	290:295	arg1	products					309:316	the acidic degradation products	286:316	the acidic degradation products	286:316	However, the acidic degradation products and burst release of PLGA microparticles still need to be ameliorated.
33034328	1	20	theme	human	187:191	arg1	hMSC					217:220	hMSC	217:220	hMSC	217:220	Incorporating poly(lactic-co-glycolic) acid (PLGA) microparticles into human mesenchymal stem cells (hMSC) aggregates has shown promising application prospects.
33034328	1	20	theme	human	187:191	arg1	cells					210:214	human mesenchymal stem cells	187:214	human mesenchymal stem cells (hMSC)	187:221	Incorporating poly(lactic-co-glycolic) acid (PLGA) microparticles into human mesenchymal stem cells (hMSC) aggregates has shown promising application prospects.
33034328	4	21	theme	hMSC	864:867	arg1	aggregates					869:878	hMSC aggregates	864:878	hMSC aggregates	864:878	The P/C-h microparticles were highly monodispersed with a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates.
33034328	3	22	from	two-phase	637:645	arg1	chip					666:669	a flow-focusing chip	650:669	a flow-focusing chip	650:669	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	4	23	theme	C-h	808:810	arg1	complex					812:818	the PLGA encapsulated C-h complex	786:818	the PLGA encapsulated C-h complex	786:818	The P/C-h microparticles were highly monodispersed with a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates.
33034328	1	24	theme	mesenchymal	193:203	arg1	hMSC					217:220	hMSC	217:220	hMSC	217:220	Incorporating poly(lactic-co-glycolic) acid (PLGA) microparticles into human mesenchymal stem cells (hMSC) aggregates has shown promising application prospects.
33034328	1	24	theme	mesenchymal	193:203	arg1	cells					210:214	human mesenchymal stem cells	187:214	human mesenchymal stem cells (hMSC)	187:221	Incorporating poly(lactic-co-glycolic) acid (PLGA) microparticles into human mesenchymal stem cells (hMSC) aggregates has shown promising application prospects.
33034328	0	25	theme	composite	22:30	arg1	microparticles					32:45	PLGA/chitosan-heparin composite microparticles	0:45	PLGA/chitosan-heparin composite microparticles	0:45	PLGA/chitosan-heparin composite microparticles prepared with microfluidics for the construction of hMSC aggregates.
33034328	4	26	theme	structure	773:781	arg1	diameter					730:737	a diameter	728:737	a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates	728:878	The P/C-h microparticles were highly monodispersed with a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates.
33034328	3	27	from	chip	666:669	arg1	composition					604:614	emulsion composition	595:614	emulsion composition	595:614	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	3	27	from	chip	666:669	arg1	rate					625:628	flow rate	620:628	flow rate	620:628	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	1	28	theme	stem	205:208	arg1	hMSC					217:220	hMSC	217:220	hMSC	217:220	Incorporating poly(lactic-co-glycolic) acid (PLGA) microparticles into human mesenchymal stem cells (hMSC) aggregates has shown promising application prospects.
33034328	1	28	theme	stem	205:208	arg1	cells					210:214	human mesenchymal stem cells	187:214	human mesenchymal stem cells (hMSC)	187:221	Incorporating poly(lactic-co-glycolic) acid (PLGA) microparticles into human mesenchymal stem cells (hMSC) aggregates has shown promising application prospects.
33034328	0	29	theme	PLGA/chitosan-heparin	0:20	arg1	microparticles					32:45	PLGA/chitosan-heparin composite microparticles	0:45	PLGA/chitosan-heparin composite microparticles	0:45	PLGA/chitosan-heparin composite microparticles prepared with microfluidics for the construction of hMSC aggregates.
33034328	4	30	theme	μm	755:756	arg1	diameter					730:737	a diameter	728:737	a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates	728:878	The P/C-h microparticles were highly monodispersed with a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates.
33034328	3	31	theme	flow	620:623	arg1	rate					625:628	flow rate	620:628	flow rate	620:628	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	3	32	from	rate	625:628	arg1	chip					666:669	a flow-focusing chip	650:669	a flow-focusing chip	650:669	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	3	33	theme	composite	438:446	arg1	microparticles					448:461	the PLGA/chitosan-heparin (P/C-h) composite microparticles	404:461	the PLGA/chitosan-heparin (P/C-h) composite microparticles	404:461	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	7	34	theme	P/C-h	1317:1321	arg1	microparticles					1323:1336	P/C-h microparticles	1317:1336	P/C-h microparticles	1317:1336	Furthermore, the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles were also enhanced.
33034328	2	35	theme	burst	322:326	arg1	release					328:334	burst release	322:334	burst release	322:334	However, the acidic degradation products and burst release of PLGA microparticles still need to be ameliorated.
33034328	4	36	theme	shell-core	762:771	arg1	structure					773:781	shell-core structure	762:781	shell-core structure	762:781	The P/C-h microparticles were highly monodispersed with a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates.
33034328	8	37	theme	hMSC	1513:1516	arg1	aggregates					1518:1527	the hMSC aggregates	1509:1527	the hMSC aggregates	1509:1527	In summary, the P/C-h composite microparticles prepared by the droplet microfluidic technique support the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy.
33034328	3	38	theme	precise	567:573	arg1	manipulation					575:586	the precise manipulation	563:586	the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip	563:669	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	7	39	from	abilities	1265:1273	arg1	aggregates					1292:1301	hMSC aggregates	1287:1301	hMSC aggregates incorporating P/C-h microparticles	1287:1336	Furthermore, the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles were also enhanced.
33034328	3	40	theme	composition	604:614	arg1	manipulation					575:586	the precise manipulation	563:586	the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip	563:669	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	8	41	theme	clinical	1555:1562	arg1	applications					1564:1575	the clinical applications	1551:1575	the clinical applications of MSC-based therapy	1551:1596	In summary, the P/C-h composite microparticles prepared by the droplet microfluidic technique support the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy.
33034328	5	42	theme	mass	890:893	arg1	ratio					895:899	the mass ratio	886:899	the mass ratio of PLGA to the C-h complex	886:926	When the mass ratio of PLGA to the C-h complex was optimized to 2 : 1, the pH of the leach liquor of P/C-h microparticles remained neutral.
33034328	7	43	theme	migration	1255:1263	arg1	abilities					1265:1273	the survival, stemness, as well as secretion and migration abilities	1206:1273	the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles	1206:1336	Furthermore, the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles were also enhanced.
33034328	5	44	theme	microparticles	988:1001	arg1	liquor					972:977	the leach liquor	962:977	the leach liquor of P/C-h microparticles	962:1001	When the mass ratio of PLGA to the C-h complex was optimized to 2 : 1, the pH of the leach liquor of P/C-h microparticles remained neutral.
33034328	1	45	theme	poly	130:133	arg1	microparticles					167:180	poly(lactic-co-glycolic) acid (PLGA) microparticles	130:180	poly(lactic-co-glycolic) acid (PLGA) microparticles	130:180	Incorporating poly(lactic-co-glycolic) acid (PLGA) microparticles into human mesenchymal stem cells (hMSC) aggregates has shown promising application prospects.
33034328	5	46	dep	2 	945:946	arg1	 1					948:949	 1	948:949	2 : 1	945:949	When the mass ratio of PLGA to the C-h complex was optimized to 2 : 1, the pH of the leach liquor of P/C-h microparticles remained neutral.
33034328	3	47	theme	P/C-h	431:435	arg1	microparticles					448:461	the PLGA/chitosan-heparin (P/C-h) composite microparticles	404:461	the PLGA/chitosan-heparin (P/C-h) composite microparticles	404:461	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	3	48	theme	two-phase	637:645	arg1	composition					604:614	emulsion composition	595:614	emulsion composition	595:614	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	3	48	theme	two-phase	637:645	arg1	rate					625:628	flow rate	620:628	flow rate	620:628	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	4	49	theme	P/C-h	676:680	arg1	microparticles					682:695	The P/C-h microparticles	672:695	The P/C-h microparticles	672:695	The P/C-h microparticles were highly monodispersed with a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates.
33034328	5	50	theme	PLGA	904:907	arg1	ratio					895:899	the mass ratio	886:899	the mass ratio of PLGA to the C-h complex	886:926	When the mass ratio of PLGA to the C-h complex was optimized to 2 : 1, the pH of the leach liquor of P/C-h microparticles remained neutral.
33034328	3	51	theme	rate	625:628	arg1	manipulation					575:586	the precise manipulation	563:586	the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip	563:669	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	6	52	theme	initial	1090:1096	arg1	release					1104:1110	the initial burst release	1086:1110	the initial burst release (loaded FGF-2 and VEGF)	1086:1134	Compared with those of PLGA microparticles, the cytotoxicity and the initial burst release (loaded FGF-2 and VEGF) were both significantly reduced in P/C-h microparticles.
33034328	1	53	theme	lactic-co-glycolic	135:152	arg1	microparticles					167:180	poly(lactic-co-glycolic) acid (PLGA) microparticles	130:180	poly(lactic-co-glycolic) acid (PLGA) microparticles	130:180	Incorporating poly(lactic-co-glycolic) acid (PLGA) microparticles into human mesenchymal stem cells (hMSC) aggregates has shown promising application prospects.
33034328	3	54	theme	PLGA/chitosan-heparin	408:428	arg1	microparticles					448:461	the PLGA/chitosan-heparin (P/C-h) composite microparticles	404:461	the PLGA/chitosan-heparin (P/C-h) composite microparticles	404:461	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	8	55	theme	therapy	1590:1596	arg1	applications					1564:1575	the clinical applications	1551:1575	the clinical applications of MSC-based therapy	1551:1596	In summary, the P/C-h composite microparticles prepared by the droplet microfluidic technique support the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy.
33034328	6	56	theme	PLGA	1044:1047	arg1	microparticles					1049:1062	PLGA microparticles	1044:1062	PLGA microparticles	1044:1062	Compared with those of PLGA microparticles, the cytotoxicity and the initial burst release (loaded FGF-2 and VEGF) were both significantly reduced in P/C-h microparticles.
33034328	8	57	theme	optimal	1464:1470	arg1	profile					1498:1504	the optimal biological and functional profile	1460:1504	the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy	1460:1596	In summary, the P/C-h composite microparticles prepared by the droplet microfluidic technique support the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy.
33034328	8	58	theme	P/C-h	1374:1378	arg1	microparticles					1390:1403	the P/C-h composite microparticles	1370:1403	the P/C-h composite microparticles prepared by the droplet microfluidic technique	1370:1450	In summary, the P/C-h composite microparticles prepared by the droplet microfluidic technique support the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy.
33034328	7	59	theme	secretion	1241:1249	arg1	abilities					1265:1273	the survival, stemness, as well as secretion and migration abilities	1206:1273	the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles	1206:1336	Furthermore, the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles were also enhanced.
33034328	4	60	theme	±	748:748	arg1	μm					755:756	23.45 ± 0.25 μm	742:756	23.45 ± 0.25 μm	742:756	The P/C-h microparticles were highly monodispersed with a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates.
33034328	8	61	theme	MSC-based	1580:1588	arg1	therapy					1590:1596	MSC-based therapy	1580:1596	MSC-based therapy	1580:1596	In summary, the P/C-h composite microparticles prepared by the droplet microfluidic technique support the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy.
33034328	5	62	theme	leach	966:970	arg1	liquor					972:977	the leach liquor	962:977	the leach liquor of P/C-h microparticles	962:1001	When the mass ratio of PLGA to the C-h complex was optimized to 2 : 1, the pH of the leach liquor of P/C-h microparticles remained neutral.
33034328	3	63	theme	flow-focusing	652:664	arg1	chip					666:669	a flow-focusing chip	650:669	a flow-focusing chip	650:669	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	7	64	from	cells	1278:1282	arg1	aggregates					1292:1301	hMSC aggregates	1287:1301	hMSC aggregates incorporating P/C-h microparticles	1287:1336	Furthermore, the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles were also enhanced.
33034328	1	65	theme	acid	155:158	arg1	microparticles					167:180	poly(lactic-co-glycolic) acid (PLGA) microparticles	130:180	poly(lactic-co-glycolic) acid (PLGA) microparticles	130:180	Incorporating poly(lactic-co-glycolic) acid (PLGA) microparticles into human mesenchymal stem cells (hMSC) aggregates has shown promising application prospects.
33034328	3	66	theme	emulsion	595:602	arg1	composition					604:614	emulsion composition	595:614	emulsion composition	595:614	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	4	67	theme	complex	812:818	arg1	μm					755:756	23.45 ± 0.25 μm	742:756	23.45 ± 0.25 μm	742:756	The P/C-h microparticles were highly monodispersed with a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates.
33034328	4	67	theme	complex	812:818	arg1	structure					773:781	shell-core structure	762:781	shell-core structure	762:781	The P/C-h microparticles were highly monodispersed with a diameter of 23.45 ± 0.25 μm and shell-core structure of the PLGA encapsulated C-h complex, which were suitable for the fabrication of hMSC aggregates.
33034328	1	68	dep	aggregates	223:232	arg1	shown					238:242	shown	238:242	aggregates has shown promising application prospects	223:274	Incorporating poly(lactic-co-glycolic) acid (PLGA) microparticles into human mesenchymal stem cells (hMSC) aggregates has shown promising application prospects.
33034328	8	69	theme	functional	1487:1496	arg1	profile					1498:1504	the optimal biological and functional profile	1460:1504	the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy	1460:1596	In summary, the P/C-h composite microparticles prepared by the droplet microfluidic technique support the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy.
33034328	2	70	theme	PLGA	339:342	arg1	microparticles					344:357	PLGA microparticles	339:357	PLGA microparticles	339:357	However, the acidic degradation products and burst release of PLGA microparticles still need to be ameliorated.
33034328	2	71	theme	microparticles	344:357	arg1	products					309:316	the acidic degradation products	286:316	the acidic degradation products	286:316	However, the acidic degradation products and burst release of PLGA microparticles still need to be ameliorated.
33034328	2	71	theme	microparticles	344:357	arg1	release					328:334	burst release	322:334	burst release	322:334	However, the acidic degradation products and burst release of PLGA microparticles still need to be ameliorated.
33034328	6	72	dep	release	1104:1110	arg1	VEGF					1130:1133	VEGF	1130:1133	VEGF	1130:1133	Compared with those of PLGA microparticles, the cytotoxicity and the initial burst release (loaded FGF-2 and VEGF) were both significantly reduced in P/C-h microparticles.
33034328	6	72	dep	release	1104:1110	arg1	FGF-2					1120:1124	FGF-2	1120:1124	FGF-2	1120:1124	Compared with those of PLGA microparticles, the cytotoxicity and the initial burst release (loaded FGF-2 and VEGF) were both significantly reduced in P/C-h microparticles.
33034328	8	73	theme	biological	1472:1481	arg1	profile					1498:1504	the optimal biological and functional profile	1460:1504	the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy	1460:1596	In summary, the P/C-h composite microparticles prepared by the droplet microfluidic technique support the optimal biological and functional profile of the hMSC aggregates, which may facilitate the clinical applications of MSC-based therapy.
33034328	6	74	theme	P/C-h	1171:1175	arg1	microparticles					1177:1190	P/C-h microparticles	1171:1190	P/C-h microparticles	1171:1190	Compared with those of PLGA microparticles, the cytotoxicity and the initial burst release (loaded FGF-2 and VEGF) were both significantly reduced in P/C-h microparticles.
33034328	1	75	theme	PLGA	161:164	arg1	microparticles					167:180	poly(lactic-co-glycolic) acid (PLGA) microparticles	130:180	poly(lactic-co-glycolic) acid (PLGA) microparticles	130:180	Incorporating poly(lactic-co-glycolic) acid (PLGA) microparticles into human mesenchymal stem cells (hMSC) aggregates has shown promising application prospects.
33034328	3	76	from	composition	604:614	arg1	chip					666:669	a flow-focusing chip	650:669	a flow-focusing chip	650:669	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	1	77	theme	promising	244:252	arg1	prospects					266:274	promising application prospects	244:274	promising application prospects	244:274	Incorporating poly(lactic-co-glycolic) acid (PLGA) microparticles into human mesenchymal stem cells (hMSC) aggregates has shown promising application prospects.
33034328	7	78	theme	survival	1210:1217	arg1	abilities					1265:1273	the survival, stemness, as well as secretion and migration abilities	1206:1273	the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles	1206:1336	Furthermore, the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles were also enhanced.
33034328	5	79	theme	P/C-h	982:986	arg1	microparticles					988:1001	P/C-h microparticles	982:1001	P/C-h microparticles	982:1001	When the mass ratio of PLGA to the C-h complex was optimized to 2 : 1, the pH of the leach liquor of P/C-h microparticles remained neutral.
33034328	7	80	from	aggregates	1292:1301	arg1	abilities					1265:1273	the survival, stemness, as well as secretion and migration abilities	1206:1273	the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles	1206:1336	Furthermore, the survival, stemness, as well as secretion and migration abilities of cells in hMSC aggregates incorporating P/C-h microparticles were also enhanced.
33034328	3	81	dep	composition	604:614	arg1	the					591:593	the	591:593	the	591:593	In this study, the PLGA/chitosan-heparin (P/C-h) composite microparticles were successfully fabricated by integrating the double emulsion and microfluidic technology through the precise manipulation of the emulsion composition and flow rate of the two-phase in a flow-focusing chip.
33034328	1	82	theme	application	254:264	arg1	prospects					266:274	promising application prospects	244:274	promising application prospects	244:274	Incorporating poly(lactic-co-glycolic) acid (PLGA) microparticles into human mesenchymal stem cells (hMSC) aggregates has shown promising application prospects.
33481068	12	0	theme	heparosan	1527:1535	arg1	yield					1506:1510	The yield	1502:1510	The yield of EcN-derived heparosan	1502:1535	The yield of EcN-derived heparosan was 3 g/L of cell free supernatant.
33481068	12	0	theme	heparosan	1527:1535	arg1	g/L					1543:1545	3 g/L	1541:1545	3 g/L of cell free supernatant	1541:1570	The yield of EcN-derived heparosan was 3 g/L of cell free supernatant.
33481068	11	1	theme	average	1465:1471	arg1	weight					1483:1488	average molecular weight	1465:1488	average molecular weight 68,000 Da	1465:1498	Size exclusion chromatography analysis shows that the heparosan purified from fermentation broth results in bimodal distribution, and cell-free supernatant results in unimodal distribution (average molecular weight 68,000 Da).
33481068	4	2	theme	unimodal	640:647	arg1	distribution					649:660	unimodal distribution	640:660	unimodal distribution	640:660	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	6	3	theme	heparosan	841:849	arg1	attributes					855:864	the heparosan CTQ attributes	837:864	the heparosan CTQ attributes	837:864	The current work explores production of EcN heparosan and process parameters that may impact the heparosan CTQ attributes.
33481068	14	4	theme	cell	1782:1785	arg1	density					1787:1793	• High cell density	1775:1793	• High cell density fermentation	1775:1806	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	2	5	theme	heparin	308:314	arg1	synthesis					245:253	chemoenzymatic synthesis	230:253	chemoenzymatic synthesis of biopharmaceutically important heparan sulfate and heparin	230:314	Heparosan serves as the substrate for chemoenzymatic synthesis of biopharmaceutically important heparan sulfate and heparin.
33481068	16	6	theme	manufacturing	2224:2236	arg1	facilities					2238:2247	manufacturing facilities	2224:2247	manufacturing facilities	2224:2247	• The media composition and the protocol (SOPs and batch records) have been successfully transferred to contract manufacturing facilities and industrial partners.
33481068	14	7	theme	bacteria	1883:1890	arg1	growth					1863:1868	the growth	1859:1868	the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan)	1859:1949	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	13	8	theme	chemical	1639:1646	arg1	modification					1648:1659	chemical modification	1639:1659	chemical modification	1639:1659	We further evaluated the application of Nissle 1917 heparosan for chemical modification to prepare N-sulfo heparosan (NSH), the first intermediate precursor for heparin and heparan sulfate.
33481068	12	9	link	EcN-derived	1515:1525	arg1	heparosan					1527:1535	EcN-derived heparosan	1515:1535	EcN-derived heparosan	1515:1535	The yield of EcN-derived heparosan was 3 g/L of cell free supernatant.
33481068	14	10	theme	High	1777:1780	arg1	density					1787:1793	• High cell density	1775:1793	• High cell density fermentation	1775:1806	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	13	11	theme	N-sulfo	1672:1678	arg1	NSH					1691:1693	NSH	1691:1693	NSH	1691:1693	We further evaluated the application of Nissle 1917 heparosan for chemical modification to prepare N-sulfo heparosan (NSH), the first intermediate precursor for heparin and heparan sulfate.
33481068	13	11	theme	N-sulfo	1672:1678	arg1	precursor					1720:1728	the first intermediate precursor	1697:1728	the first intermediate precursor for heparin and heparan sulfate	1697:1760	We further evaluated the application of Nissle 1917 heparosan for chemical modification to prepare N-sulfo heparosan (NSH), the first intermediate precursor for heparin and heparan sulfate.
33481068	13	11	theme	N-sulfo	1672:1678	arg1	heparosan					1680:1688	N-sulfo heparosan	1672:1688	N-sulfo heparosan (NSH)	1672:1694	We further evaluated the application of Nissle 1917 heparosan for chemical modification to prepare N-sulfo heparosan (NSH), the first intermediate precursor for heparin and heparan sulfate.
33481068	4	12	theme	CTQ	488:490	arg1	attributes					493:502	The critical-to-quality (CTQ) attributes	463:502	The critical-to-quality (CTQ) attributes for heparosan applications	463:529	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	13	13	theme	heparosan	1625:1633	arg1	application					1598:1608	the application	1594:1608	the application of Nissle 1917 heparosan for chemical modification	1594:1659	We further evaluated the application of Nissle 1917 heparosan for chemical modification to prepare N-sulfo heparosan (NSH), the first intermediate precursor for heparin and heparan sulfate.
33481068	14	14	theme	natural	1920:1926	arg1	1917					1912:1915	E. coli Nissle 1917	1897:1915	E. coli Nissle 1917	1897:1915	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	14	14	theme	natural	1920:1926	arg1	producer					1928:1935	a natural producer	1918:1935	a natural producer of heparosan	1918:1948	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	14	15	dep	bacteria	1883:1890	arg1	EcN					1892:1894	EcN	1892:1894	probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan)	1873:1949	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	5	16	theme	natural	713:719	arg1	producer					721:728	a natural producer	711:728	a natural producer of heparosan	711:741	Probiotic bacteria E. coli Nissle 1917 (EcN) is a natural producer of heparosan.
33481068	5	16	theme	natural	713:719	arg1	bacteria					673:680	Probiotic bacteria	663:680	Probiotic bacteria E. coli Nissle 1917 (EcN)	663:706	Probiotic bacteria E. coli Nissle 1917 (EcN) is a natural producer of heparosan.
33481068	14	17	theme	KEY	1763:1765	arg1	POINTS					1767:1772	KEY POINTS	1763:1772	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.	1763:1962	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	2	18	theme	chemoenzymatic	230:243	arg1	synthesis					245:253	chemoenzymatic synthesis	230:253	chemoenzymatic synthesis of biopharmaceutically important heparan sulfate and heparin	230:314	Heparosan serves as the substrate for chemoenzymatic synthesis of biopharmaceutically important heparan sulfate and heparin.
33481068	2	19	theme	sulfate	296:302	arg1	synthesis					245:253	chemoenzymatic synthesis	230:253	chemoenzymatic synthesis of biopharmaceutically important heparan sulfate and heparin	230:314	Heparosan serves as the substrate for chemoenzymatic synthesis of biopharmaceutically important heparan sulfate and heparin.
33481068	14	20	theme	Nissle	1905:1910	arg1	1917					1912:1915	E. coli Nissle 1917	1897:1915	E. coli Nissle 1917	1897:1915	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	14	20	theme	Nissle	1905:1910	arg1	producer					1928:1935	a natural producer	1918:1935	a natural producer of heparosan	1918:1948	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	4	21	theme	critical-to-quality	467:485	arg1	attributes					493:502	The critical-to-quality (CTQ) attributes	463:502	The critical-to-quality (CTQ) attributes for heparosan applications	463:529	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	9	22	theme	chemical	1056:1063	arg1	composition					1065:1075	The chemical composition	1052:1075	The chemical composition of heparosan from EcN	1052:1097	The chemical composition of heparosan from EcN was confirmed using nuclear magnetic resonance.
33481068	0	23	theme	1917	54:57	arg1	fermentation					13:24	High density fermentation	0:24	High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification.	0:123	High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification.
33481068	13	24	theme	Nissle	1613:1618	arg1	heparosan					1625:1633	Nissle 1917 heparosan	1613:1633	Nissle 1917 heparosan	1613:1633	We further evaluated the application of Nissle 1917 heparosan for chemical modification to prepare N-sulfo heparosan (NSH), the first intermediate precursor for heparin and heparan sulfate.
33481068	14	25	theme	E.	1897:1898	arg1	1917					1912:1915	E. coli Nissle 1917	1897:1915	E. coli Nissle 1917	1897:1915	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	14	25	theme	E.	1897:1898	arg1	producer					1928:1935	a natural producer	1918:1935	a natural producer of heparosan	1918:1948	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	3	26	theme	non-toxic	359:367	arg1	molecule					349:356	biologically inert molecule	330:356	biologically inert molecule	330:356	Heparosan is biologically inert molecule, non-toxic, and non-immunogenic and these qualities of heparosan make it an ideal drug delivery vehicle.
33481068	16	27	theme	media	2117:2121	arg1	composition					2123:2133	• The media composition	2111:2133	• The media composition	2111:2133	• The media composition and the protocol (SOPs and batch records) have been successfully transferred to contract manufacturing facilities and industrial partners.
33481068	0	28	theme	heparosan	67:75	arg1	production					77:86	heparosan production	67:86	heparosan production	67:86	High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification.
33481068	1	29	theme	non-sulfated	160:171	arg1	Heparosan					125:133	Heparosan	125:133	Heparosan	125:133	Heparosan is a naturally occurring non-sulfated glycosaminoglycan.
33481068	1	29	theme	non-sulfated	160:171	arg1	glycosaminoglycan					173:189	a naturally occurring non-sulfated glycosaminoglycan	138:189	a naturally occurring non-sulfated glycosaminoglycan	138:189	Heparosan is a naturally occurring non-sulfated glycosaminoglycan.
33481068	5	30	theme	Probiotic	663:671	arg1	producer					721:728	a natural producer	711:728	a natural producer of heparosan	711:741	Probiotic bacteria E. coli Nissle 1917 (EcN) is a natural producer of heparosan.
33481068	5	30	theme	Probiotic	663:671	arg1	bacteria					673:680	Probiotic bacteria	663:680	Probiotic bacteria E. coli Nissle 1917 (EcN)	663:706	Probiotic bacteria E. coli Nissle 1917 (EcN) is a natural producer of heparosan.
33481068	4	31	theme	heparosan	508:516	arg1	applications					518:529	heparosan applications	508:529	heparosan applications	508:529	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	11	32	theme	bimodal	1383:1389	arg1	distribution					1391:1402	bimodal distribution	1383:1402	bimodal distribution	1383:1402	Size exclusion chromatography analysis shows that the heparosan purified from fermentation broth results in bimodal distribution, and cell-free supernatant results in unimodal distribution (average molecular weight 68,000 Da).
33481068	15	33	dep	bacteria	2051:2058	arg1	Nissle					2065:2070	Nissle	2065:2070	Nissle	2065:2070	• Process parameters towards the production of monodispersed heparosan using probiotic bacteria EcN (Nissle 1917) has been explored and discussed.
33481068	15	33	dep	bacteria	2051:2058	arg1	EcN					2060:2062	EcN	2060:2062	EcN	2060:2062	• Process parameters towards the production of monodispersed heparosan using probiotic bacteria EcN (Nissle 1917) has been explored and discussed.
33481068	15	34	theme	•	1964:1964	arg1	parameters					1974:1983	• Process parameters	1964:1983	• Process parameters towards the production of monodispersed heparosan using probiotic bacteria EcN (Nissle 1917)	1964:2076	• Process parameters towards the production of monodispersed heparosan using probiotic bacteria EcN (Nissle 1917) has been explored and discussed.
33481068	0	35	theme	High	0:3	arg1	fermentation					13:24	High density fermentation	0:24	High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification.	0:123	High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification.
33481068	10	36	theme	heparosan	1172:1180	arg1	distribution					1199:1210	heparosan molecular weight distribution	1172:1210	heparosan molecular weight distribution	1172:1210	Results demonstrate that heparosan molecular weight distribution may be influenced by fermentation and purification conditions.
33481068	2	37	theme	important	278:286	arg1	sulfate					296:302	biopharmaceutically important heparan sulfate	258:302	biopharmaceutically important heparan sulfate	258:302	Heparosan serves as the substrate for chemoenzymatic synthesis of biopharmaceutically important heparan sulfate and heparin.
33481068	3	38	theme	heparosan	413:421	arg1	qualities					400:408	these qualities	394:408	these qualities of heparosan	394:421	Heparosan is biologically inert molecule, non-toxic, and non-immunogenic and these qualities of heparosan make it an ideal drug delivery vehicle.
33481068	11	39	theme	chromatography	1290:1303	arg1	analysis					1305:1312	Size exclusion chromatography analysis	1275:1312	Size exclusion chromatography analysis	1275:1312	Size exclusion chromatography analysis shows that the heparosan purified from fermentation broth results in bimodal distribution, and cell-free supernatant results in unimodal distribution (average molecular weight 68,000 Da).
33481068	9	40	theme	magnetic	1127:1134	arg1	resonance					1136:1144	nuclear magnetic resonance	1119:1144	nuclear magnetic resonance	1119:1144	The chemical composition of heparosan from EcN was confirmed using nuclear magnetic resonance.
33481068	3	41	theme	delivery	445:452	arg1	vehicle					454:460	an ideal drug delivery vehicle	431:460	an ideal drug delivery vehicle	431:460	Heparosan is biologically inert molecule, non-toxic, and non-immunogenic and these qualities of heparosan make it an ideal drug delivery vehicle.
33481068	4	42	theme	heparosan	604:612	arg1	size					631:634	heparosan molecular weight size	604:634	heparosan molecular weight size	604:634	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	11	43	theme	Size	1275:1278	arg1	chromatography					1290:1303	Size exclusion chromatography	1275:1303	Size exclusion chromatography analysis	1275:1312	Size exclusion chromatography analysis shows that the heparosan purified from fermentation broth results in bimodal distribution, and cell-free supernatant results in unimodal distribution (average molecular weight 68,000 Da).
33481068	0	44	theme	probiotic	29:37	arg1	1917					54:57	probiotic E. coli Nissle 1917	29:57	probiotic E. coli Nissle 1917	29:57	High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification.
33481068	5	45	dep	E.	682:683	arg1	coli					685:688	coli	685:688	coli	685:688	Probiotic bacteria E. coli Nissle 1917 (EcN) is a natural producer of heparosan.
33481068	15	46	theme	probiotic	2041:2049	arg1	bacteria					2051:2058	probiotic bacteria	2041:2058	probiotic bacteria EcN (Nissle 1917)	2041:2076	• Process parameters towards the production of monodispersed heparosan using probiotic bacteria EcN (Nissle 1917) has been explored and discussed.
33481068	10	47	theme	weight	1192:1197	arg1	distribution					1199:1210	heparosan molecular weight distribution	1172:1210	heparosan molecular weight distribution	1172:1210	Results demonstrate that heparosan molecular weight distribution may be influenced by fermentation and purification conditions.
33481068	12	48	theme	cell	1550:1553	arg1	supernatant					1560:1570	cell free supernatant	1550:1570	cell free supernatant	1550:1570	The yield of EcN-derived heparosan was 3 g/L of cell free supernatant.
33481068	4	49	theme	unnatural	580:588	arg1	moieties					590:597	any unnatural moieties	576:597	any unnatural moieties	576:597	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	13	50	theme	first	1701:1705	arg1	heparosan					1680:1688	N-sulfo heparosan	1672:1688	N-sulfo heparosan (NSH)	1672:1694	We further evaluated the application of Nissle 1917 heparosan for chemical modification to prepare N-sulfo heparosan (NSH), the first intermediate precursor for heparin and heparan sulfate.
33481068	13	50	theme	first	1701:1705	arg1	precursor					1720:1728	the first intermediate precursor	1697:1728	the first intermediate precursor for heparin and heparan sulfate	1697:1760	We further evaluated the application of Nissle 1917 heparosan for chemical modification to prepare N-sulfo heparosan (NSH), the first intermediate precursor for heparin and heparan sulfate.
33481068	14	51	dep	POINTS	1767:1772	arg1	reported					1954:1961	reported	1954:1961	is reported	1951:1961	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	6	52	theme	EcN	784:786	arg1	heparosan					788:796	EcN heparosan	784:796	EcN heparosan	784:796	The current work explores production of EcN heparosan and process parameters that may impact the heparosan CTQ attributes.
33481068	14	53	theme	defined	1828:1834	arg1	media					1849:1853	a chemically defined fermentation media	1815:1853	a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan)	1815:1949	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	12	54	theme	supernatant	1560:1570	arg1	yield					1506:1510	The yield	1502:1510	The yield of EcN-derived heparosan	1502:1535	The yield of EcN-derived heparosan was 3 g/L of cell free supernatant.
33481068	12	54	theme	supernatant	1560:1570	arg1	g/L					1543:1545	3 g/L	1541:1545	3 g/L of cell free supernatant	1541:1570	The yield of EcN-derived heparosan was 3 g/L of cell free supernatant.
33481068	11	55	theme	molecular	1473:1481	arg1	weight					1483:1488	average molecular weight	1465:1488	average molecular weight 68,000 Da	1465:1498	Size exclusion chromatography analysis shows that the heparosan purified from fermentation broth results in bimodal distribution, and cell-free supernatant results in unimodal distribution (average molecular weight 68,000 Da).
33481068	9	56	from	EcN	1095:1097	arg1	composition					1065:1075	The chemical composition	1052:1075	The chemical composition of heparosan from EcN	1052:1097	The chemical composition of heparosan from EcN was confirmed using nuclear magnetic resonance.
33481068	3	57	theme	ideal	434:438	arg1	vehicle					454:460	an ideal drug delivery vehicle	431:460	an ideal drug delivery vehicle	431:460	Heparosan is biologically inert molecule, non-toxic, and non-immunogenic and these qualities of heparosan make it an ideal drug delivery vehicle.
33481068	8	58	theme	fermentation	978:989	arg1	process					991:997	The fermentation process	974:997	The fermentation process	974:997	The fermentation process is successfully scaled from 5-L to 100-L bioreactor.
33481068	16	59	theme	batch	2162:2166	arg1	records					2168:2174	batch records	2162:2174	batch records	2162:2174	• The media composition and the protocol (SOPs and batch records) have been successfully transferred to contract manufacturing facilities and industrial partners.
33481068	4	60	theme	weight	624:629	arg1	size					631:634	heparosan molecular weight size	604:634	heparosan molecular weight size	604:634	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	16	61	theme	industrial	2253:2262	arg1	partners					2264:2271	industrial partners	2253:2271	industrial partners	2253:2271	• The media composition and the protocol (SOPs and batch records) have been successfully transferred to contract manufacturing facilities and industrial partners.
33481068	16	62	dep	protocol	2143:2150	arg1	records					2168:2174	batch records	2162:2174	batch records	2162:2174	• The media composition and the protocol (SOPs and batch records) have been successfully transferred to contract manufacturing facilities and industrial partners.
33481068	16	62	dep	protocol	2143:2150	arg1	SOPs					2153:2156	SOPs	2153:2156	SOPs	2153:2156	• The media composition and the protocol (SOPs and batch records) have been successfully transferred to contract manufacturing facilities and industrial partners.
33481068	6	63	theme	CTQ	851:853	arg1	attributes					855:864	the heparosan CTQ attributes	837:864	the heparosan CTQ attributes	837:864	The current work explores production of EcN heparosan and process parameters that may impact the heparosan CTQ attributes.
33481068	7	64	theme	high	907:910	arg1	OD600					928:932	OD600 160-180	928:940	OD600 160-180	928:940	Results show that EcN could be grown to high cell densities (OD600 160-180) in a chemically defined media.
33481068	7	64	theme	high	907:910	arg1	densities					917:925	high cell densities	907:925	high cell densities (OD600 160-180)	907:941	Results show that EcN could be grown to high cell densities (OD600 160-180) in a chemically defined media.
33481068	10	65	theme	purification	1250:1261	arg1	conditions					1263:1272	purification conditions	1250:1272	purification conditions	1250:1272	Results demonstrate that heparosan molecular weight distribution may be influenced by fermentation and purification conditions.
33481068	5	66	theme	E.	682:683	arg1	producer					721:728	a natural producer	711:728	a natural producer of heparosan	711:741	Probiotic bacteria E. coli Nissle 1917 (EcN) is a natural producer of heparosan.
33481068	5	66	theme	E.	682:683	arg1	bacteria					673:680	Probiotic bacteria	663:680	Probiotic bacteria E. coli Nissle 1917 (EcN)	663:706	Probiotic bacteria E. coli Nissle 1917 (EcN) is a natural producer of heparosan.
33481068	12	67	theme	EcN-derived	1515:1525	arg1	heparosan					1527:1535	EcN-derived heparosan	1515:1535	EcN-derived heparosan	1515:1535	The yield of EcN-derived heparosan was 3 g/L of cell free supernatant.
33481068	11	68	theme	cell-free	1409:1417	arg1	supernatant					1419:1429	cell-free supernatant	1409:1429	cell-free supernatant	1409:1429	Size exclusion chromatography analysis shows that the heparosan purified from fermentation broth results in bimodal distribution, and cell-free supernatant results in unimodal distribution (average molecular weight 68,000 Da).
33481068	11	69	dep	distribution	1451:1462	arg1	weight					1483:1488	average molecular weight	1465:1488	average molecular weight 68,000 Da	1465:1498	Size exclusion chromatography analysis shows that the heparosan purified from fermentation broth results in bimodal distribution, and cell-free supernatant results in unimodal distribution (average molecular weight 68,000 Da).
33481068	8	70	theme	100-L	1034:1038	arg1	bioreactor					1040:1049	100-L bioreactor	1034:1049	100-L bioreactor	1034:1049	The fermentation process is successfully scaled from 5-L to 100-L bioreactor.
33481068	14	71	theme	density	1787:1793	arg1	fermentation					1795:1806	• High cell density fermentation	1775:1806	• High cell density fermentation	1775:1806	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	5	72	theme	heparosan	733:741	arg1	producer					721:728	a natural producer	711:728	a natural producer of heparosan	711:741	Probiotic bacteria E. coli Nissle 1917 (EcN) is a natural producer of heparosan.
33481068	5	72	theme	heparosan	733:741	arg1	bacteria					673:680	Probiotic bacteria	663:680	Probiotic bacteria E. coli Nissle 1917 (EcN)	663:706	Probiotic bacteria E. coli Nissle 1917 (EcN) is a natural producer of heparosan.
33481068	6	73	theme	parameters	810:819	arg1	production					770:779	production	770:779	production of EcN heparosan and process parameters that may impact the heparosan CTQ attributes	770:864	The current work explores production of EcN heparosan and process parameters that may impact the heparosan CTQ attributes.
33481068	14	74	theme	heparosan	1940:1948	arg1	1917					1912:1915	E. coli Nissle 1917	1897:1915	E. coli Nissle 1917	1897:1915	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	14	74	theme	heparosan	1940:1948	arg1	producer					1928:1935	a natural producer	1918:1935	a natural producer of heparosan	1918:1948	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	11	75	theme	unimodal	1442:1449	arg1	distribution					1451:1462	unimodal distribution	1442:1462	unimodal distribution (average molecular weight 68,000 Da)	1442:1499	Size exclusion chromatography analysis shows that the heparosan purified from fermentation broth results in bimodal distribution, and cell-free supernatant results in unimodal distribution (average molecular weight 68,000 Da).
33481068	14	76	theme	•	1775:1775	arg1	density					1787:1793	• High cell density	1775:1793	• High cell density fermentation	1775:1806	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	13	77	theme	1917	1620:1623	arg1	heparosan					1625:1633	Nissle 1917 heparosan	1613:1633	Nissle 1917 heparosan	1613:1633	We further evaluated the application of Nissle 1917 heparosan for chemical modification to prepare N-sulfo heparosan (NSH), the first intermediate precursor for heparin and heparan sulfate.
33481068	11	78	dep	weight	1483:1488	arg1	Da					1497:1498	68,000 Da	1490:1498	average molecular weight 68,000 Da	1465:1498	Size exclusion chromatography analysis shows that the heparosan purified from fermentation broth results in bimodal distribution, and cell-free supernatant results in unimodal distribution (average molecular weight 68,000 Da).
33481068	10	79	theme	molecular	1182:1190	arg1	distribution					1199:1210	heparosan molecular weight distribution	1172:1210	heparosan molecular weight distribution	1172:1210	Results demonstrate that heparosan molecular weight distribution may be influenced by fermentation and purification conditions.
33481068	15	80	theme	heparosan	2025:2033	arg1	production					1997:2006	the production	1993:2006	the production of monodispersed heparosan using probiotic bacteria EcN (Nissle 1917)	1993:2076	• Process parameters towards the production of monodispersed heparosan using probiotic bacteria EcN (Nissle 1917) has been explored and discussed.
33481068	3	81	theme	inert	343:347	arg1	molecule					349:356	biologically inert molecule	330:356	biologically inert molecule	330:356	Heparosan is biologically inert molecule, non-toxic, and non-immunogenic and these qualities of heparosan make it an ideal drug delivery vehicle.
33481068	2	82	theme	heparan	288:294	arg1	sulfate					296:302	biopharmaceutically important heparan sulfate	258:302	biopharmaceutically important heparan sulfate	258:302	Heparosan serves as the substrate for chemoenzymatic synthesis of biopharmaceutically important heparan sulfate and heparin.
33481068	14	83	theme	coli	1900:1903	arg1	1917					1912:1915	E. coli Nissle 1917	1897:1915	E. coli Nissle 1917	1897:1915	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	14	83	theme	coli	1900:1903	arg1	producer					1928:1935	a natural producer	1918:1935	a natural producer of heparosan	1918:1948	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	3	84	theme	non-immunogenic	374:388	arg1	molecule					349:356	biologically inert molecule	330:356	biologically inert molecule	330:356	Heparosan is biologically inert molecule, non-toxic, and non-immunogenic and these qualities of heparosan make it an ideal drug delivery vehicle.
33481068	4	85	theme	heparosan	554:562	arg1	composition					539:549	composition	539:549	composition of heparosan	539:562	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	4	85	theme	heparosan	554:562	arg1	size					631:634	heparosan molecular weight size	604:634	heparosan molecular weight size	604:634	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	4	85	theme	heparosan	554:562	arg1	distribution					649:660	unimodal distribution	640:660	unimodal distribution	640:660	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	4	85	theme	heparosan	554:562	arg1	absence					565:571	absence	565:571	absence of any unnatural moieties	565:597	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	1	86	theme	occurring	150:158	arg1	Heparosan					125:133	Heparosan	125:133	Heparosan	125:133	Heparosan is a naturally occurring non-sulfated glycosaminoglycan.
33481068	1	86	theme	occurring	150:158	arg1	glycosaminoglycan					173:189	a naturally occurring non-sulfated glycosaminoglycan	138:189	a naturally occurring non-sulfated glycosaminoglycan	138:189	Heparosan is a naturally occurring non-sulfated glycosaminoglycan.
33481068	15	87	theme	monodispersed	2011:2023	arg1	heparosan					2025:2033	monodispersed heparosan	2011:2033	monodispersed heparosan using probiotic bacteria EcN (Nissle 1917)	2011:2076	• Process parameters towards the production of monodispersed heparosan using probiotic bacteria EcN (Nissle 1917) has been explored and discussed.
33481068	9	88	theme	heparosan	1080:1088	arg1	composition					1065:1075	The chemical composition	1052:1075	The chemical composition of heparosan from EcN	1052:1097	The chemical composition of heparosan from EcN was confirmed using nuclear magnetic resonance.
33481068	6	89	theme	current	748:754	arg1	work					756:759	The current work	744:759	The current work	744:759	The current work explores production of EcN heparosan and process parameters that may impact the heparosan CTQ attributes.
33481068	0	90	theme	density	5:11	arg1	fermentation					13:24	High density fermentation	0:24	High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification.	0:123	High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification.
33481068	7	91	theme	defined	959:965	arg1	media					967:971	a chemically defined media	946:971	a chemically defined media	946:971	Results show that EcN could be grown to high cell densities (OD600 160-180) in a chemically defined media.
33481068	15	92	theme	Process	1966:1972	arg1	parameters					1974:1983	• Process parameters	1964:1983	• Process parameters towards the production of monodispersed heparosan using probiotic bacteria EcN (Nissle 1917)	1964:2076	• Process parameters towards the production of monodispersed heparosan using probiotic bacteria EcN (Nissle 1917) has been explored and discussed.
33481068	13	93	theme	heparan	1746:1752	arg1	sulfate					1754:1760	heparan sulfate	1746:1760	heparan sulfate	1746:1760	We further evaluated the application of Nissle 1917 heparosan for chemical modification to prepare N-sulfo heparosan (NSH), the first intermediate precursor for heparin and heparan sulfate.
33481068	9	94	theme	nuclear	1119:1125	arg1	resonance					1136:1144	nuclear magnetic resonance	1119:1144	nuclear magnetic resonance	1119:1144	The chemical composition of heparosan from EcN was confirmed using nuclear magnetic resonance.
33481068	14	95	theme	probiotic	1873:1881	arg1	bacteria					1883:1890	probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan)	1873:1949	probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan)	1873:1949	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	4	96	theme	molecular	614:622	arg1	size					631:634	heparosan molecular weight size	604:634	heparosan molecular weight size	604:634	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	0	97	theme	E.	39:40	arg1	1917					54:57	probiotic E. coli Nissle 1917	29:57	probiotic E. coli Nissle 1917	29:57	High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification.
33481068	11	98	theme	exclusion	1280:1288	arg1	chromatography					1290:1303	Size exclusion chromatography	1275:1303	Size exclusion chromatography analysis	1275:1312	Size exclusion chromatography analysis shows that the heparosan purified from fermentation broth results in bimodal distribution, and cell-free supernatant results in unimodal distribution (average molecular weight 68,000 Da).
33481068	6	99	theme	process	802:808	arg1	parameters					810:819	EcN heparosan and process parameters	784:819	EcN heparosan and process parameters that may impact the heparosan CTQ attributes	784:864	The current work explores production of EcN heparosan and process parameters that may impact the heparosan CTQ attributes.
33481068	0	100	theme	Nissle	47:52	arg1	1917					54:57	probiotic E. coli Nissle 1917	29:57	probiotic E. coli Nissle 1917	29:57	High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification.
33481068	0	101	dep	E.	39:40	arg1	coli					42:45	coli	42:45	coli	42:45	High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification.
33481068	3	102	theme	drug	440:443	arg1	vehicle					454:460	an ideal drug delivery vehicle	431:460	an ideal drug delivery vehicle	431:460	Heparosan is biologically inert molecule, non-toxic, and non-immunogenic and these qualities of heparosan make it an ideal drug delivery vehicle.
33481068	4	103	theme	moieties	590:597	arg1	composition					539:549	composition	539:549	composition of heparosan	539:562	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	4	103	theme	moieties	590:597	arg1	size					631:634	heparosan molecular weight size	604:634	heparosan molecular weight size	604:634	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	4	103	theme	moieties	590:597	arg1	distribution					649:660	unimodal distribution	640:660	unimodal distribution	640:660	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	4	103	theme	moieties	590:597	arg1	absence					565:571	absence	565:571	absence of any unnatural moieties	565:597	The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution.
33481068	6	104	theme	heparosan	788:796	arg1	parameters					810:819	EcN heparosan and process parameters	784:819	EcN heparosan and process parameters that may impact the heparosan CTQ attributes	784:864	The current work explores production of EcN heparosan and process parameters that may impact the heparosan CTQ attributes.
33481068	14	105	dep	EcN	1892:1894	arg1	1917					1912:1915	E. coli Nissle 1917	1897:1915	E. coli Nissle 1917	1897:1915	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	14	105	dep	EcN	1892:1894	arg1	producer					1928:1935	a natural producer	1918:1935	a natural producer of heparosan	1918:1948	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	14	106	theme	fermentation	1836:1847	arg1	media					1849:1853	a chemically defined fermentation media	1815:1853	a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan)	1815:1949	KEY POINTS: • High cell density fermentation, using a chemically defined fermentation media for the growth of probiotic bacteria EcN (E. coli Nissle 1917, a natural producer of heparosan) is reported.
33481068	5	107	dep	bacteria	673:680	arg1	Nissle					690:695	Nissle	690:695	Nissle	690:695	Probiotic bacteria E. coli Nissle 1917 (EcN) is a natural producer of heparosan.
33481068	5	107	dep	bacteria	673:680	arg1	EcN					703:705	EcN	703:705	EcN	703:705	Probiotic bacteria E. coli Nissle 1917 (EcN) is a natural producer of heparosan.
33481068	13	108	theme	intermediate	1707:1718	arg1	heparosan					1680:1688	N-sulfo heparosan	1672:1688	N-sulfo heparosan (NSH)	1672:1694	We further evaluated the application of Nissle 1917 heparosan for chemical modification to prepare N-sulfo heparosan (NSH), the first intermediate precursor for heparin and heparan sulfate.
33481068	13	108	theme	intermediate	1707:1718	arg1	precursor					1720:1728	the first intermediate precursor	1697:1728	the first intermediate precursor for heparin and heparan sulfate	1697:1760	We further evaluated the application of Nissle 1917 heparosan for chemical modification to prepare N-sulfo heparosan (NSH), the first intermediate precursor for heparin and heparan sulfate.
33481068	12	109	theme	free	1555:1558	arg1	supernatant					1560:1570	cell free supernatant	1550:1570	cell free supernatant	1550:1570	The yield of EcN-derived heparosan was 3 g/L of cell free supernatant.
33481068	7	110	theme	cell	912:915	arg1	OD600					928:932	OD600 160-180	928:940	OD600 160-180	928:940	Results show that EcN could be grown to high cell densities (OD600 160-180) in a chemically defined media.
33481068	7	110	theme	cell	912:915	arg1	densities					917:925	high cell densities	907:925	high cell densities (OD600 160-180)	907:941	Results show that EcN could be grown to high cell densities (OD600 160-180) in a chemically defined media.
32717991	8	0	theme	sodium	1389:1394	arg1	severity					1412:1419	dextran sulfate sodium induced colitis severity	1373:1419	dextran sulfate sodium induced colitis severity	1373:1419	Prolonged pretreatment with PM not only diminished susceptibility to dextran sulfate sodium induced colitis severity, but also caused enhanced immune regulation.
32717991	6	1	from	mice	1027:1030	arg1	abundant					1004:1011	abundant	1004:1011	abundant	1004:1011	Specific taxa that were significantly more abundant in PM-treated mice include Akkermansia muciniphila and several Bacteroides members.
32717991	5	2	contain	had	872:874	arg2	abundance					936:944	lower abundance	930:944	lower abundance of Firmicutes	930:958	Compared to control mice, the gut microbiota of PM-treated mice had significantly higher abundance of Verrucomicrobia and lower abundance of Firmicutes.
32717991	5	2	contain	had	872:874	arg2	abundance					897:905	significantly higher abundance	876:905	significantly higher abundance of Verrucomicrobia	876:924	Compared to control mice, the gut microbiota of PM-treated mice had significantly higher abundance of Verrucomicrobia and lower abundance of Firmicutes.
32717991	5	2	contain	had	872:874	arg1	microbiota					842:851	the gut microbiota	834:851	the gut microbiota of PM-treated mice	834:870	Compared to control mice, the gut microbiota of PM-treated mice had significantly higher abundance of Verrucomicrobia and lower abundance of Firmicutes.
32717991	3	3	theme	derived	474:480	arg1	β-1,3-d-glucan					482:495	a microalgae derived β-1,3-d-glucan	461:495	a microalgae derived β-1,3-d-glucan	461:495	Here, using C57BL/6 mice, we show the potential of a microalgae derived β-1,3-d-glucan, paramylon (PM), in shaping the gut microbiota and modulating the susceptibility to colitis.
32717991	3	3	theme	derived	474:480	arg1	paramylon					498:506	paramylon	498:506	paramylon (PM)	498:511	Here, using C57BL/6 mice, we show the potential of a microalgae derived β-1,3-d-glucan, paramylon (PM), in shaping the gut microbiota and modulating the susceptibility to colitis.
32717991	8	4	theme	induced	1396:1402	arg1	severity					1412:1419	dextran sulfate sodium induced colitis severity	1373:1419	dextran sulfate sodium induced colitis severity	1373:1419	Prolonged pretreatment with PM not only diminished susceptibility to dextran sulfate sodium induced colitis severity, but also caused enhanced immune regulation.
32717991	8	5	theme	dextran	1373:1379	arg1	sodium					1389:1394	dextran sulfate sodium	1373:1394	dextran sulfate sodium induced colitis severity	1373:1419	Prolonged pretreatment with PM not only diminished susceptibility to dextran sulfate sodium induced colitis severity, but also caused enhanced immune regulation.
32717991	5	6	theme	higher	890:895	arg1	abundance					897:905	significantly higher abundance	876:905	significantly higher abundance of Verrucomicrobia	876:924	Compared to control mice, the gut microbiota of PM-treated mice had significantly higher abundance of Verrucomicrobia and lower abundance of Firmicutes.
32717991	0	7	from	Microbiota	53:62	arg1	Dynamics					0:7	Dynamics	0:7	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.	0:153	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	8	8	theme	enhanced	1438:1445	arg1	regulation					1454:1463	enhanced immune regulation	1438:1463	enhanced immune regulation	1438:1463	Prolonged pretreatment with PM not only diminished susceptibility to dextran sulfate sodium induced colitis severity, but also caused enhanced immune regulation.
32717991	1	9	theme	immune	251:256	arg1	regulation					258:267	immune regulation	251:267	immune regulation	251:267	Previously, we have shown that oral administration of yeast derived β-1,3/1,6-d-glucan enhances immune regulation and alters the composition of the gut microbiota.
32717991	0	10	theme	Microalgal	88:97	arg1	Paramylon					109:117	Paramylon	109:117	Paramylon	109:117	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	0	10	theme	Microalgal	88:97	arg1	β-Glucan					99:106	a Microalgal β-Glucan	86:106	a Microalgal β-Glucan	86:106	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	0	11	from	Dynamics	0:7	arg1	Microbiota					53:62	Gut Microbiota	49:62	Gut Microbiota	49:62	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	7	12	theme	carbohydrate	1159:1170	arg1	metabolism					1172:1181	carbohydrate metabolism	1159:1181	carbohydrate metabolism function	1159:1190	Predictive functional analysis revealed overrepresentation of carbohydrate metabolism function in the fecal microbiota of PM recipients compared to controls, and this function was linked to Bacteroides spp.
32717991	0	13	with	Treatment	71:79	arg1	Paramylon					109:117	Paramylon	109:117	Paramylon	109:117	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	0	13	with	Treatment	71:79	arg1	Impact					127:132	the Impact	123:132	the Impact on Gut Inflammation	123:152	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	0	13	with	Treatment	71:79	arg1	β-Glucan					99:106	a Microalgal β-Glucan	86:106	a Microalgal β-Glucan	86:106	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	4	14	theme	community	734:742	arg1	richness					744:751	community richness	734:751	community richness	734:751	The community structure within the gut microbiota showed progressive changes including selective enrichment of specific communities and lowered community richness and diversity during prolonged oral treatment with PM.
32717991	4	15	with	treatment	789:797	arg1	PM					804:805	PM	804:805	PM	804:805	The community structure within the gut microbiota showed progressive changes including selective enrichment of specific communities and lowered community richness and diversity during prolonged oral treatment with PM.
32717991	9	16	theme	oral	1574:1577	arg1	consumption					1579:1589	its prolonged oral consumption	1560:1589	its prolonged oral consumption to gut health	1560:1603	Overall, this study demonstrates the prebiotic properties of PM and the potential benefits of its prolonged oral consumption to gut health.
32717991	7	17	theme	metabolism	1172:1181	arg1	function					1183:1190	carbohydrate metabolism function	1159:1190	carbohydrate metabolism function	1159:1190	Predictive functional analysis revealed overrepresentation of carbohydrate metabolism function in the fecal microbiota of PM recipients compared to controls, and this function was linked to Bacteroides spp.
32717991	4	18	theme	selective	677:685	arg1	enrichment					687:696	selective enrichment	677:696	selective enrichment of specific communities	677:720	The community structure within the gut microbiota showed progressive changes including selective enrichment of specific communities and lowered community richness and diversity during prolonged oral treatment with PM.
32717991	5	19	theme	lower	930:934	arg1	abundance					936:944	lower abundance	930:944	lower abundance of Firmicutes	930:958	Compared to control mice, the gut microbiota of PM-treated mice had significantly higher abundance of Verrucomicrobia and lower abundance of Firmicutes.
32717991	7	20	theme	recipients	1222:1231	arg1	microbiota					1205:1214	the fecal microbiota	1195:1214	the fecal microbiota of PM recipients	1195:1231	Predictive functional analysis revealed overrepresentation of carbohydrate metabolism function in the fecal microbiota of PM recipients compared to controls, and this function was linked to Bacteroides spp.
32717991	4	21	theme	prolonged	774:782	arg1	treatment					789:797	prolonged oral treatment	774:797	prolonged oral treatment with PM	774:805	The community structure within the gut microbiota showed progressive changes including selective enrichment of specific communities and lowered community richness and diversity during prolonged oral treatment with PM.
32717991	5	22	theme	PM-treated	856:865	arg1	mice					867:870	PM-treated mice	856:870	PM-treated mice	856:870	Compared to control mice, the gut microbiota of PM-treated mice had significantly higher abundance of Verrucomicrobia and lower abundance of Firmicutes.
32717991	3	23	theme	C57BL/6	422:428	arg1	mice					430:433	C57BL/6 mice	422:433	C57BL/6 mice	422:433	Here, using C57BL/6 mice, we show the potential of a microalgae derived β-1,3-d-glucan, paramylon (PM), in shaping the gut microbiota and modulating the susceptibility to colitis.
32717991	0	24	from	Changes	38:44	arg1	Microbiota					53:62	Gut Microbiota	49:62	Gut Microbiota	49:62	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	1	25	link	derived	215:221	arg1	β-1,3/1,6-d-glucan					223:240	yeast derived β-1,3/1,6-d-glucan	209:240	yeast derived β-1,3/1,6-d-glucan	209:240	Previously, we have shown that oral administration of yeast derived β-1,3/1,6-d-glucan enhances immune regulation and alters the composition of the gut microbiota.
32717991	9	26	theme	gut	1594:1596	arg1	health					1598:1603	gut health	1594:1603	gut health	1594:1603	Overall, this study demonstrates the prebiotic properties of PM and the potential benefits of its prolonged oral consumption to gut health.
32717991	8	27	with	pretreatment	1314:1325	arg1	PM					1332:1333	PM	1332:1333	PM	1332:1333	Prolonged pretreatment with PM not only diminished susceptibility to dextran sulfate sodium induced colitis severity, but also caused enhanced immune regulation.
32717991	2	28	theme	distinct	366:373	arg1	β-glucans					375:383	other structurally distinct β-glucans	347:383	other structurally distinct β-glucans	347:383	However, it is not known if other structurally distinct β-glucans have similar properties.
32717991	6	29	theme	Akkermansia	1040:1050	arg1	muciniphila					1052:1062	Akkermansia muciniphila and several Bacteroides members	1040:1094	muciniphila	1052:1062	Specific taxa that were significantly more abundant in PM-treated mice include Akkermansia muciniphila and several Bacteroides members.
32717991	6	30	from	abundant	1004:1011	arg1	mice					1027:1030	PM-treated mice	1016:1030	PM-treated mice	1016:1030	Specific taxa that were significantly more abundant in PM-treated mice include Akkermansia muciniphila and several Bacteroides members.
32717991	4	31	theme	gut	625:627	arg1	microbiota					629:638	the gut microbiota	621:638	the gut microbiota	621:638	The community structure within the gut microbiota showed progressive changes including selective enrichment of specific communities and lowered community richness and diversity during prolonged oral treatment with PM.
32717991	3	32	theme	gut	529:531	arg1	microbiota					533:542	the gut microbiota	525:542	the gut microbiota	525:542	Here, using C57BL/6 mice, we show the potential of a microalgae derived β-1,3-d-glucan, paramylon (PM), in shaping the gut microbiota and modulating the susceptibility to colitis.
32717991	5	33	theme	mice	867:870	arg1	microbiota					842:851	the gut microbiota	834:851	the gut microbiota of PM-treated mice	834:870	Compared to control mice, the gut microbiota of PM-treated mice had significantly higher abundance of Verrucomicrobia and lower abundance of Firmicutes.
32717991	7	34	theme	PM	1219:1220	arg1	recipients					1222:1231	PM recipients	1219:1231	PM recipients	1219:1231	Predictive functional analysis revealed overrepresentation of carbohydrate metabolism function in the fecal microbiota of PM recipients compared to controls, and this function was linked to Bacteroides spp.
32717991	3	35	link	derived	474:480	arg1	β-1,3-d-glucan					482:495	a microalgae derived β-1,3-d-glucan	461:495	a microalgae derived β-1,3-d-glucan	461:495	Here, using C57BL/6 mice, we show the potential of a microalgae derived β-1,3-d-glucan, paramylon (PM), in shaping the gut microbiota and modulating the susceptibility to colitis.
32717991	3	35	link	derived	474:480	arg1	paramylon					498:506	paramylon	498:506	paramylon (PM)	498:511	Here, using C57BL/6 mice, we show the potential of a microalgae derived β-1,3-d-glucan, paramylon (PM), in shaping the gut microbiota and modulating the susceptibility to colitis.
32717991	9	36	theme	prebiotic	1503:1511	arg1	properties					1513:1522	the prebiotic properties	1499:1522	the prebiotic properties of PM	1499:1528	Overall, this study demonstrates the prebiotic properties of PM and the potential benefits of its prolonged oral consumption to gut health.
32717991	5	37	theme	Firmicutes	949:958	arg1	abundance					936:944	lower abundance	930:944	lower abundance of Firmicutes	930:958	Compared to control mice, the gut microbiota of PM-treated mice had significantly higher abundance of Verrucomicrobia and lower abundance of Firmicutes.
32717991	5	37	theme	Firmicutes	949:958	arg1	abundance					897:905	significantly higher abundance	876:905	significantly higher abundance of Verrucomicrobia	876:924	Compared to control mice, the gut microbiota of PM-treated mice had significantly higher abundance of Verrucomicrobia and lower abundance of Firmicutes.
32717991	4	38	theme	community	594:602	arg1	structure					604:612	The community structure	590:612	The community structure within the gut microbiota	590:638	The community structure within the gut microbiota showed progressive changes including selective enrichment of specific communities and lowered community richness and diversity during prolonged oral treatment with PM.
32717991	0	39	theme	Structural	12:21	arg1	Changes					38:44	Structural and Functional Changes	12:44	Structural and Functional Changes in Gut Microbiota	12:62	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	9	40	theme	consumption	1579:1589	arg1	properties					1513:1522	the prebiotic properties	1499:1522	the prebiotic properties of PM	1499:1528	Overall, this study demonstrates the prebiotic properties of PM and the potential benefits of its prolonged oral consumption to gut health.
32717991	9	40	theme	consumption	1579:1589	arg1	benefits					1548:1555	the potential benefits	1534:1555	the potential benefits of its prolonged oral consumption to gut health	1534:1603	Overall, this study demonstrates the prebiotic properties of PM and the potential benefits of its prolonged oral consumption to gut health.
32717991	7	41	theme	functional	1108:1117	arg1	analysis					1119:1126	Predictive functional analysis	1097:1126	Predictive functional analysis	1097:1126	Predictive functional analysis revealed overrepresentation of carbohydrate metabolism function in the fecal microbiota of PM recipients compared to controls, and this function was linked to Bacteroides spp.
32717991	1	42	dep	derived	215:221	arg1	yeast					209:213	yeast	209:213	yeast	209:213	Previously, we have shown that oral administration of yeast derived β-1,3/1,6-d-glucan enhances immune regulation and alters the composition of the gut microbiota.
32717991	3	43	theme	β-1,3-d-glucan	482:495	arg1	potential					448:456	the potential	444:456	the potential of a microalgae derived β-1,3-d-glucan, paramylon (PM), in shaping the gut microbiota and modulating the susceptibility to colitis	444:587	Here, using C57BL/6 mice, we show the potential of a microalgae derived β-1,3-d-glucan, paramylon (PM), in shaping the gut microbiota and modulating the susceptibility to colitis.
32717991	6	44	theme	several	1068:1074	arg1	members					1088:1094	Akkermansia muciniphila and several Bacteroides members	1040:1094	members	1088:1094	Specific taxa that were significantly more abundant in PM-treated mice include Akkermansia muciniphila and several Bacteroides members.
32717991	0	45	theme	Changes	38:44	arg1	Dynamics					0:7	Dynamics	0:7	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.	0:153	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	6	46	theme	Specific	961:968	arg1	taxa					970:973	Specific taxa	961:973	Specific taxa that were significantly more abundant in PM-treated mice	961:1030	Specific taxa that were significantly more abundant in PM-treated mice include Akkermansia muciniphila and several Bacteroides members.
32717991	9	47	theme	potential	1538:1546	arg1	benefits					1548:1555	the potential benefits	1534:1555	the potential benefits of its prolonged oral consumption to gut health	1534:1603	Overall, this study demonstrates the prebiotic properties of PM and the potential benefits of its prolonged oral consumption to gut health.
32717991	8	48	theme	sulfate	1381:1387	arg1	sodium					1389:1394	dextran sulfate sodium	1373:1394	dextran sulfate sodium induced colitis severity	1373:1419	Prolonged pretreatment with PM not only diminished susceptibility to dextran sulfate sodium induced colitis severity, but also caused enhanced immune regulation.
32717991	9	49	theme	PM	1527:1528	arg1	properties					1513:1522	the prebiotic properties	1499:1522	the prebiotic properties of PM	1499:1528	Overall, this study demonstrates the prebiotic properties of PM and the potential benefits of its prolonged oral consumption to gut health.
32717991	9	49	theme	PM	1527:1528	arg1	benefits					1548:1555	the potential benefits	1534:1555	the potential benefits of its prolonged oral consumption to gut health	1534:1603	Overall, this study demonstrates the prebiotic properties of PM and the potential benefits of its prolonged oral consumption to gut health.
32717991	1	50	theme	oral	186:189	arg1	administration					191:204	oral administration	186:204	oral administration of yeast derived β-1,3/1,6-d-glucan	186:240	Previously, we have shown that oral administration of yeast derived β-1,3/1,6-d-glucan enhances immune regulation and alters the composition of the gut microbiota.
32717991	0	51	theme	Functional	27:36	arg1	Changes					38:44	Structural and Functional Changes	12:44	Structural and Functional Changes in Gut Microbiota	12:62	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	7	52	theme	function	1183:1190	arg1	overrepresentation					1137:1154	overrepresentation	1137:1154	overrepresentation of carbohydrate metabolism function	1137:1190	Predictive functional analysis revealed overrepresentation of carbohydrate metabolism function in the fecal microbiota of PM recipients compared to controls, and this function was linked to Bacteroides spp.
32717991	7	53	attach	linked	1277:1282	arg2	function					1264:1271	this function	1259:1271	this function	1259:1271	Predictive functional analysis revealed overrepresentation of carbohydrate metabolism function in the fecal microbiota of PM recipients compared to controls, and this function was linked to Bacteroides spp.
32717991	7	53	attach	linked	1277:1282	arg1	spp					1299:1301	Bacteroides spp	1287:1301	Bacteroides spp	1287:1301	Predictive functional analysis revealed overrepresentation of carbohydrate metabolism function in the fecal microbiota of PM recipients compared to controls, and this function was linked to Bacteroides spp.
32717991	6	54	theme	PM-treated	1016:1025	arg1	mice					1027:1030	PM-treated mice	1016:1030	PM-treated mice	1016:1030	Specific taxa that were significantly more abundant in PM-treated mice include Akkermansia muciniphila and several Bacteroides members.
32717991	2	55	theme	similar	390:396	arg1	properties					398:407	similar properties	390:407	similar properties	390:407	However, it is not known if other structurally distinct β-glucans have similar properties.
32717991	0	56	theme	Gut	49:51	arg1	Microbiota					53:62	Gut Microbiota	49:62	Gut Microbiota	49:62	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	1	57	theme	gut	303:305	arg1	microbiota					307:316	the gut microbiota	299:316	the gut microbiota	299:316	Previously, we have shown that oral administration of yeast derived β-1,3/1,6-d-glucan enhances immune regulation and alters the composition of the gut microbiota.
32717991	0	58	theme	Gut	137:139	arg1	Inflammation					141:152	Gut Inflammation	137:152	Gut Inflammation	137:152	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	2	59	contain	have	385:388	arg1	β-glucans					375:383	other structurally distinct β-glucans	347:383	other structurally distinct β-glucans	347:383	However, it is not known if other structurally distinct β-glucans have similar properties.
32717991	2	59	contain	have	385:388	arg2	properties					398:407	similar properties	390:407	similar properties	390:407	However, it is not known if other structurally distinct β-glucans have similar properties.
32717991	7	60	theme	fecal	1199:1203	arg1	microbiota					1205:1214	the fecal microbiota	1195:1214	the fecal microbiota of PM recipients	1195:1231	Predictive functional analysis revealed overrepresentation of carbohydrate metabolism function in the fecal microbiota of PM recipients compared to controls, and this function was linked to Bacteroides spp.
32717991	1	61	theme	microbiota	307:316	arg1	composition					284:294	the composition	280:294	the composition of the gut microbiota	280:316	Previously, we have shown that oral administration of yeast derived β-1,3/1,6-d-glucan enhances immune regulation and alters the composition of the gut microbiota.
32717991	7	62	theme	Predictive	1097:1106	arg1	analysis					1119:1126	Predictive functional analysis	1097:1126	Predictive functional analysis	1097:1126	Predictive functional analysis revealed overrepresentation of carbohydrate metabolism function in the fecal microbiota of PM recipients compared to controls, and this function was linked to Bacteroides spp.
32717991	5	63	theme	Verrucomicrobia	910:924	arg1	abundance					936:944	lower abundance	930:944	lower abundance of Firmicutes	930:958	Compared to control mice, the gut microbiota of PM-treated mice had significantly higher abundance of Verrucomicrobia and lower abundance of Firmicutes.
32717991	5	63	theme	Verrucomicrobia	910:924	arg1	abundance					897:905	significantly higher abundance	876:905	significantly higher abundance of Verrucomicrobia	876:924	Compared to control mice, the gut microbiota of PM-treated mice had significantly higher abundance of Verrucomicrobia and lower abundance of Firmicutes.
32717991	0	64	from	β-Glucan	99:106	arg1	Inflammation					141:152	Gut Inflammation	137:152	Gut Inflammation	137:152	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	8	65	theme	Prolonged	1304:1312	arg1	pretreatment					1314:1325	Prolonged pretreatment	1304:1325	Prolonged pretreatment with PM	1304:1333	Prolonged pretreatment with PM not only diminished susceptibility to dextran sulfate sodium induced colitis severity, but also caused enhanced immune regulation.
32717991	4	66	theme	communities	710:720	arg1	enrichment					687:696	selective enrichment	677:696	selective enrichment of specific communities	677:720	The community structure within the gut microbiota showed progressive changes including selective enrichment of specific communities and lowered community richness and diversity during prolonged oral treatment with PM.
32717991	8	67	theme	immune	1447:1452	arg1	regulation					1454:1463	enhanced immune regulation	1438:1463	enhanced immune regulation	1438:1463	Prolonged pretreatment with PM not only diminished susceptibility to dextran sulfate sodium induced colitis severity, but also caused enhanced immune regulation.
32717991	0	68	from	Impact	127:132	arg1	Inflammation					141:152	Gut Inflammation	137:152	Gut Inflammation	137:152	Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation.
32717991	4	69	theme	oral	784:787	arg1	treatment					789:797	prolonged oral treatment	774:797	prolonged oral treatment with PM	774:805	The community structure within the gut microbiota showed progressive changes including selective enrichment of specific communities and lowered community richness and diversity during prolonged oral treatment with PM.
32717991	4	70	theme	specific	701:708	arg1	communities					710:720	specific communities	701:720	specific communities	701:720	The community structure within the gut microbiota showed progressive changes including selective enrichment of specific communities and lowered community richness and diversity during prolonged oral treatment with PM.
32717991	8	71	theme	colitis	1404:1410	arg1	severity					1412:1419	dextran sulfate sodium induced colitis severity	1373:1419	dextran sulfate sodium induced colitis severity	1373:1419	Prolonged pretreatment with PM not only diminished susceptibility to dextran sulfate sodium induced colitis severity, but also caused enhanced immune regulation.
32717991	9	72	theme	prolonged	1564:1572	arg1	consumption					1579:1589	its prolonged oral consumption	1560:1589	its prolonged oral consumption to gut health	1560:1603	Overall, this study demonstrates the prebiotic properties of PM and the potential benefits of its prolonged oral consumption to gut health.
32717991	5	73	theme	gut	838:840	arg1	microbiota					842:851	the gut microbiota	834:851	the gut microbiota of PM-treated mice	834:870	Compared to control mice, the gut microbiota of PM-treated mice had significantly higher abundance of Verrucomicrobia and lower abundance of Firmicutes.
32717991	6	74	theme	Bacteroides	1076:1086	arg1	members					1088:1094	Akkermansia muciniphila and several Bacteroides members	1040:1094	members	1088:1094	Specific taxa that were significantly more abundant in PM-treated mice include Akkermansia muciniphila and several Bacteroides members.
32717991	2	75	theme	other	347:351	arg1	β-glucans					375:383	other structurally distinct β-glucans	347:383	other structurally distinct β-glucans	347:383	However, it is not known if other structurally distinct β-glucans have similar properties.
32717991	1	76	theme	derived	215:221	arg1	β-1,3/1,6-d-glucan					223:240	yeast derived β-1,3/1,6-d-glucan	209:240	yeast derived β-1,3/1,6-d-glucan	209:240	Previously, we have shown that oral administration of yeast derived β-1,3/1,6-d-glucan enhances immune regulation and alters the composition of the gut microbiota.
32717991	5	77	theme	control	820:826	arg1	mice					828:831	control mice	820:831	control mice	820:831	Compared to control mice, the gut microbiota of PM-treated mice had significantly higher abundance of Verrucomicrobia and lower abundance of Firmicutes.
32717991	4	78	theme	progressive	647:657	arg1	changes					659:665	progressive changes	647:665	progressive changes including selective enrichment of specific communities	647:720	The community structure within the gut microbiota showed progressive changes including selective enrichment of specific communities and lowered community richness and diversity during prolonged oral treatment with PM.
32717991	4	78	theme	progressive	647:657	arg1	enrichment					687:696	selective enrichment	677:696	selective enrichment of specific communities	677:720	The community structure within the gut microbiota showed progressive changes including selective enrichment of specific communities and lowered community richness and diversity during prolonged oral treatment with PM.
32717991	7	79	theme	Bacteroides	1287:1297	arg1	spp					1299:1301	Bacteroides spp	1287:1301	Bacteroides spp	1287:1301	Predictive functional analysis revealed overrepresentation of carbohydrate metabolism function in the fecal microbiota of PM recipients compared to controls, and this function was linked to Bacteroides spp.
32717991	1	80	theme	β-1,3/1,6-d-glucan	223:240	arg1	administration					191:204	oral administration	186:204	oral administration of yeast derived β-1,3/1,6-d-glucan	186:240	Previously, we have shown that oral administration of yeast derived β-1,3/1,6-d-glucan enhances immune regulation and alters the composition of the gut microbiota.
33709986	1	0	theme	closest	154:160	arg1	properties					143:152	properties	143:152	properties closest to that of the extracellular matrix	143:196	Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine.
33709986	4	1	theme	different	732:740	arg1	types					742:746	different types	732:746	different types	732:746	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	1	theme	different	732:740	arg1	skin					785:788	skin	785:788	skin	785:788	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	1	theme	different	732:740	arg1	cartilage					795:803	cartilage	795:803	cartilage	795:803	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	1	theme	different	732:740	arg1	vascular					775:782	vascular	775:782	vascular	775:782	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	1	theme	different	732:740	arg1	bone					769:772	bone	769:772	bone	769:772	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	1	2	theme	tissue	231:236	arg1	engineering					238:248	tissue engineering	231:248	tissue engineering	231:248	Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine.
33709986	7	3	theme	rapid	1131:1135	arg1	methods					1149:1155	modern or rapid prototyping methods	1121:1155	modern or rapid prototyping methods	1121:1155	Implementing novel composites that combine this polymer with other materials through modern or rapid prototyping methods can open up a great prospect in the future of tissue engineering and regenerative medicine.
33709986	4	4	from	scaffold	720:727	arg1	types					742:746	different types	732:746	different types	732:746	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	4	from	scaffold	720:727	arg1	skin					785:788	skin	785:788	skin	785:788	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	4	from	scaffold	720:727	arg1	cartilage					795:803	cartilage	795:803	cartilage	795:803	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	4	from	scaffold	720:727	arg1	vascular					775:782	vascular	775:782	vascular	775:782	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	4	from	scaffold	720:727	arg1	bone					769:772	bone	769:772	bone	769:772	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	6	5	theme	scaffolds	1025:1033	arg1	design					1008:1013	the design	1004:1013	the design of tissue scaffolds	1004:1033	Given the data presented in this study, BC polymer could be suggested as a favorable natural polymer in the design of tissue scaffolds.
33709986	7	6	theme	medicine	1239:1246	arg1	future					1193:1198	future	1193:1198	future	1193:1198	Implementing novel composites that combine this polymer with other materials through modern or rapid prototyping methods can open up a great prospect in the future of tissue engineering and regenerative medicine.
33709986	5	7	theme	BC	887:888	arg1	polymers					890:897	BC polymers	887:897	BC polymers	887:897	Also, we mentioned the biological and mechanical advantages and disadvantages of BC polymers.
33709986	3	8	theme	polymerization	519:532	arg1	hydrophilicity					467:480	high hydrophilicity	462:480	high hydrophilicity	462:480	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	8	theme	polymerization	519:532	arg1	degree					509:514	a high degree	502:514	a high degree of polymerization	502:532	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	8	theme	polymerization	519:532	arg1	crystallinity					483:495	crystallinity	483:495	crystallinity	483:495	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	8	theme	polymerization	519:532	arg1	properties					450:459	excellent mechanical properties	429:459	excellent mechanical properties	429:459	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	7	9	theme	modern	1121:1126	arg1	methods					1149:1155	modern or rapid prototyping methods	1121:1155	modern or rapid prototyping methods	1121:1155	Implementing novel composites that combine this polymer with other materials through modern or rapid prototyping methods can open up a great prospect in the future of tissue engineering and regenerative medicine.
33709986	0	10	from	Polymer	49:55	arg1	Engineering					67:77	Tissue Engineering	60:77	Tissue Engineering	60:77	Applications of Bacterial Cellulose as a Natural Polymer in Tissue Engineering.
33709986	1	11	with	properties	143:152	arg1	potential					129:137	the best regeneration potential	107:137	the best regeneration potential	107:137	Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine.
33709986	2	12	theme	Natural	277:283	arg1	polymers					285:292	Natural polymers	277:292	Natural polymers	277:292	Natural polymers, such as collagen, elastin, and cellulose, are widely used for this purpose in tissue engineering.
33709986	2	12	theme	Natural	277:283	arg1	elastin					313:319	elastin	313:319	elastin	313:319	Natural polymers, such as collagen, elastin, and cellulose, are widely used for this purpose in tissue engineering.
33709986	2	12	theme	Natural	277:283	arg1	cellulose					326:334	cellulose	326:334	cellulose	326:334	Natural polymers, such as collagen, elastin, and cellulose, are widely used for this purpose in tissue engineering.
33709986	2	12	theme	Natural	277:283	arg1	collagen					303:310	collagen	303:310	collagen	303:310	Natural polymers, such as collagen, elastin, and cellulose, are widely used for this purpose in tissue engineering.
33709986	1	13	theme	regenerative	254:265	arg1	medicine					267:274	regenerative medicine	254:274	regenerative medicine	254:274	Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine.
33709986	7	14	theme	other	1097:1101	arg1	materials					1103:1111	other materials	1097:1111	other materials	1097:1111	Implementing novel composites that combine this polymer with other materials through modern or rapid prototyping methods can open up a great prospect in the future of tissue engineering and regenerative medicine.
33709986	4	15	from	trends	652:657	arg1	application					666:676	the application	662:676	the application of bacterial cellulose (BC) polymers	662:713	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	3	16	theme	high	504:507	arg1	degree					509:514	a high degree	502:514	a high degree of polymerization	502:532	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	16	theme	high	504:507	arg1	properties					450:459	excellent mechanical properties	429:459	excellent mechanical properties	429:459	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	5	17	dep	advantages	855:864	arg1	the					825:827	the	825:827	the	825:827	Also, we mentioned the biological and mechanical advantages and disadvantages of BC polymers.
33709986	7	18	theme	novel	1049:1053	arg1	composites					1055:1064	novel composites	1049:1064	novel composites that combine this polymer with other materials	1049:1111	Implementing novel composites that combine this polymer with other materials through modern or rapid prototyping methods can open up a great prospect in the future of tissue engineering and regenerative medicine.
33709986	6	19	theme	tissue	1018:1023	arg1	scaffolds					1025:1033	tissue scaffolds	1018:1033	tissue scaffolds	1018:1033	Given the data presented in this study, BC polymer could be suggested as a favorable natural polymer in the design of tissue scaffolds.
33709986	6	20	theme	favorable	975:983	arg1	polymer					993:999	a favorable natural polymer	973:999	a favorable natural polymer in the design of tissue scaffolds	973:1033	Given the data presented in this study, BC polymer could be suggested as a favorable natural polymer in the design of tissue scaffolds.
33709986	6	20	theme	favorable	975:983	arg1	polymer					943:949	BC polymer	940:949	BC polymer	940:949	Given the data presented in this study, BC polymer could be suggested as a favorable natural polymer in the design of tissue scaffolds.
33709986	1	21	with	material	93:100	arg1	potential					129:137	the best regeneration potential	107:137	the best regeneration potential	107:137	Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine.
33709986	7	22	theme	prototyping	1137:1147	arg1	methods					1149:1155	modern or rapid prototyping methods	1121:1155	modern or rapid prototyping methods	1121:1155	Implementing novel composites that combine this polymer with other materials through modern or rapid prototyping methods can open up a great prospect in the future of tissue engineering and regenerative medicine.
33709986	4	23	theme	current	614:620	arg1	study					622:626	the current study	610:626	the current study	610:626	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	3	24	attach	derived	403:409	arg2	Cellulose					393:401	Cellulose	393:401	Cellulose derived from bacteria	393:423	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	24	attach	derived	403:409	arg1	bacteria					416:423	bacteria	416:423	bacteria	416:423	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	4	25	theme	cellulose	691:699	arg1	polymers					706:713	bacterial cellulose (BC) polymers	681:713	bacterial cellulose (BC) polymers	681:713	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	1	26	theme	extracellular	177:189	arg1	matrix					191:196	the extracellular matrix	173:196	the extracellular matrix	173:196	Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine.
33709986	0	27	theme	Cellulose	26:34	arg1	Applications					0:11	Applications	0:11	Applications of Bacterial Cellulose as a Natural Polymer in Tissue Engineering.	0:78	Applications of Bacterial Cellulose as a Natural Polymer in Tissue Engineering.
33709986	5	28	theme	mechanical	844:853	arg1	advantages					855:864	advantages	855:864	advantages	855:864	Also, we mentioned the biological and mechanical advantages and disadvantages of BC polymers.
33709986	3	29	theme	mechanical	439:448	arg1	hydrophilicity					467:480	high hydrophilicity	462:480	high hydrophilicity	462:480	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	29	theme	mechanical	439:448	arg1	degree					509:514	a high degree	502:514	a high degree of polymerization	502:532	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	29	theme	mechanical	439:448	arg1	crystallinity					483:495	crystallinity	483:495	crystallinity	483:495	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	29	theme	mechanical	439:448	arg1	properties					450:459	excellent mechanical properties	429:459	excellent mechanical properties	429:459	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	0	30	theme	Bacterial	16:24	arg1	Cellulose					26:34	Bacterial Cellulose	16:34	Bacterial Cellulose	16:34	Applications of Bacterial Cellulose as a Natural Polymer in Tissue Engineering.
33709986	4	31	theme	BC	702:703	arg1	polymers					706:713	bacterial cellulose (BC) polymers	681:713	bacterial cellulose (BC) polymers	681:713	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	7	32	theme	engineering	1210:1220	arg1	future					1193:1198	future	1193:1198	future	1193:1198	Implementing novel composites that combine this polymer with other materials through modern or rapid prototyping methods can open up a great prospect in the future of tissue engineering and regenerative medicine.
33709986	5	33	theme	biological	829:838	arg1	advantages					855:864	advantages	855:864	advantages	855:864	Also, we mentioned the biological and mechanical advantages and disadvantages of BC polymers.
33709986	3	34	contain	has	425:427	arg2	properties					450:459	excellent mechanical properties	429:459	excellent mechanical properties	429:459	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	34	contain	has	425:427	arg1	Cellulose					393:401	Cellulose	393:401	Cellulose derived from bacteria	393:423	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	34	contain	has	425:427	arg2	crystallinity					483:495	crystallinity	483:495	crystallinity	483:495	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	34	contain	has	425:427	arg2	degree					509:514	a high degree	502:514	a high degree of polymerization	502:532	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	34	contain	has	425:427	arg2	hydrophilicity					467:480	high hydrophilicity	462:480	high hydrophilicity	462:480	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	7	35	theme	regenerative	1226:1237	arg1	medicine					1239:1246	regenerative medicine	1226:1246	regenerative medicine	1226:1246	Implementing novel composites that combine this polymer with other materials through modern or rapid prototyping methods can open up a great prospect in the future of tissue engineering and regenerative medicine.
33709986	2	36	theme	tissue	373:378	arg1	engineering					380:390	tissue engineering	373:390	tissue engineering	373:390	Natural polymers, such as collagen, elastin, and cellulose, are widely used for this purpose in tissue engineering.
33709986	6	37	theme	natural	985:991	arg1	polymer					993:999	a favorable natural polymer	973:999	a favorable natural polymer in the design of tissue scaffolds	973:1033	Given the data presented in this study, BC polymer could be suggested as a favorable natural polymer in the design of tissue scaffolds.
33709986	6	37	theme	natural	985:991	arg1	polymer					943:949	BC polymer	940:949	BC polymer	940:949	Given the data presented in this study, BC polymer could be suggested as a favorable natural polymer in the design of tissue scaffolds.
33709986	4	38	theme	polymers	706:713	arg1	application					666:676	the application	662:676	the application of bacterial cellulose (BC) polymers	662:713	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	39	theme	tissue	751:756	arg1	types					742:746	different types	732:746	different types	732:746	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	39	theme	tissue	751:756	arg1	skin					785:788	skin	785:788	skin	785:788	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	39	theme	tissue	751:756	arg1	cartilage					795:803	cartilage	795:803	cartilage	795:803	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	39	theme	tissue	751:756	arg1	vascular					775:782	vascular	775:782	vascular	775:782	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	39	theme	tissue	751:756	arg1	bone					769:772	bone	769:772	bone	769:772	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	3	40	theme	excellent	429:437	arg1	hydrophilicity					467:480	high hydrophilicity	462:480	high hydrophilicity	462:480	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	40	theme	excellent	429:437	arg1	degree					509:514	a high degree	502:514	a high degree of polymerization	502:532	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	40	theme	excellent	429:437	arg1	crystallinity					483:495	crystallinity	483:495	crystallinity	483:495	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	40	theme	excellent	429:437	arg1	properties					450:459	excellent mechanical properties	429:459	excellent mechanical properties	429:459	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	1	41	from	challenges	217:226	arg1	engineering					238:248	tissue engineering	231:248	tissue engineering	231:248	Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine.
33709986	1	41	from	challenges	217:226	arg1	medicine					267:274	regenerative medicine	254:274	regenerative medicine	254:274	Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine.
33709986	5	42	theme	polymers	890:897	arg1	disadvantages					870:882	disadvantages	870:882	disadvantages	870:882	Also, we mentioned the biological and mechanical advantages and disadvantages of BC polymers.
33709986	5	42	theme	polymers	890:897	arg1	advantages					855:864	advantages	855:864	advantages	855:864	Also, we mentioned the biological and mechanical advantages and disadvantages of BC polymers.
33709986	0	43	theme	Natural	41:47	arg1	Polymer					49:55	a Natural Polymer	39:55	a Natural Polymer in Tissue Engineering	39:77	Applications of Bacterial Cellulose as a Natural Polymer in Tissue Engineering.
33709986	1	44	theme	best	111:114	arg1	potential					129:137	the best regeneration potential	107:137	the best regeneration potential	107:137	Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine.
33709986	3	45	dep	has	425:427	arg1	used					557:560	used	557:560	can be used as scaffold/membrane for tissue engineering	550:604	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	46	theme	tissue	587:592	arg1	engineering					594:604	tissue engineering	587:604	tissue engineering	587:604	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	1	47	theme	regeneration	116:127	arg1	potential					129:137	the best regeneration potential	107:137	the best regeneration potential	107:137	Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine.
33709986	6	48	theme	BC	940:941	arg1	polymer					943:949	BC polymer	940:949	BC polymer	940:949	Given the data presented in this study, BC polymer could be suggested as a favorable natural polymer in the design of tissue scaffolds.
33709986	6	48	theme	BC	940:941	arg1	polymer					993:999	a favorable natural polymer	973:999	a favorable natural polymer in the design of tissue scaffolds	973:1033	Given the data presented in this study, BC polymer could be suggested as a favorable natural polymer in the design of tissue scaffolds.
33709986	4	49	theme	bacterial	681:689	arg1	polymers					706:713	bacterial cellulose (BC) polymers	681:713	bacterial cellulose (BC) polymers	681:713	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	2	50	used	used	348:351	arg2	collagen					303:310	collagen	303:310	collagen	303:310	Natural polymers, such as collagen, elastin, and cellulose, are widely used for this purpose in tissue engineering.
33709986	2	50	used	used	348:351	arg2	polymers					285:292	Natural polymers	277:292	Natural polymers	277:292	Natural polymers, such as collagen, elastin, and cellulose, are widely used for this purpose in tissue engineering.
33709986	2	50	used	used	348:351	arg2	cellulose					326:334	cellulose	326:334	cellulose	326:334	Natural polymers, such as collagen, elastin, and cellulose, are widely used for this purpose in tissue engineering.
33709986	2	50	used	used	348:351	arg2	elastin					313:319	elastin	313:319	elastin	313:319	Natural polymers, such as collagen, elastin, and cellulose, are widely used for this purpose in tissue engineering.
33709986	3	51	theme	high	462:465	arg1	hydrophilicity					467:480	high hydrophilicity	462:480	high hydrophilicity	462:480	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	3	51	theme	high	462:465	arg1	properties					450:459	excellent mechanical properties	429:459	excellent mechanical properties	429:459	Cellulose derived from bacteria has excellent mechanical properties, high hydrophilicity, crystallinity, and a high degree of polymerization and, therefore, can be used as scaffold/membrane for tissue engineering.
33709986	1	52	theme	main	212:215	arg1	challenges					217:226	the main challenges	208:226	the main challenges in tissue engineering and regenerative medicine	208:274	Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine.
33709986	0	53	theme	Tissue	60:65	arg1	Engineering					67:77	Tissue Engineering	60:77	Tissue Engineering	60:77	Applications of Bacterial Cellulose as a Natural Polymer in Tissue Engineering.
33709986	6	54	from	polymer	993:999	arg1	design					1008:1013	the design	1004:1013	the design of tissue scaffolds	1004:1033	Given the data presented in this study, BC polymer could be suggested as a favorable natural polymer in the design of tissue scaffolds.
33709986	4	55	theme	latest	645:650	arg1	trends					652:657	the latest trends	641:657	the latest trends in the application of bacterial cellulose (BC) polymers	641:713	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	4	55	theme	latest	645:650	arg1	scaffold					720:727	a scaffold	718:727	a scaffold in different types of tissue, including bone, vascular, skin, and cartilage	718:803	In the current study, we reviewed the latest trends in the application of bacterial cellulose (BC) polymers as a scaffold in different types of tissue, including bone, vascular, skin, and cartilage.
33709986	7	56	theme	tissue	1203:1208	arg1	engineering					1210:1220	tissue engineering	1203:1220	tissue engineering	1203:1220	Implementing novel composites that combine this polymer with other materials through modern or rapid prototyping methods can open up a great prospect in the future of tissue engineering and regenerative medicine.
33709986	1	57	theme	challenges	217:226	arg1	challenges					217:226	the main challenges	208:226	the main challenges in tissue engineering and regenerative medicine	208:274	Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine.
33709986	1	57	theme	challenges	217:226	arg1	one					201:203	one	201:203	one	201:203	Choosing the material with the best regeneration potential and properties closest to that of the extracellular matrix is one of the main challenges in tissue engineering and regenerative medicine.
33709986	7	58	theme	great	1171:1175	arg1	prospect					1177:1184	a great prospect	1169:1184	a great prospect	1169:1184	Implementing novel composites that combine this polymer with other materials through modern or rapid prototyping methods can open up a great prospect in the future of tissue engineering and regenerative medicine.
33458940	4	0	theme	green	533:537	arg1	system					577:582	the green and highly efficient KOH/urea aqueous system	529:582	the green and highly efficient KOH/urea aqueous system for the first time	529:601	Herein, novel chitin/chitosan composite hydrogels are fabricated from the green and highly efficient KOH/urea aqueous system for the first time.
33458940	8	1	theme	chitosan	1135:1142	arg1	loading					1144:1150	chitosan loading	1135:1150	chitosan loading	1135:1150	L929 cells proliferate and intend to form cell aggregates, and the size of the cell aggregates becomes greater with the increase of chitosan loading.
33458940	7	2	theme	regular	926:932	arg1	spheroids					951:959	regular 3D multicellular spheroids	926:959	regular 3D multicellular spheroids	926:959	The cell studies show that NIH-3T3 cells self-assemble to form regular 3D multicellular spheroids on the CCGEL samples with high viability.
33458940	4	3	theme	efficient	550:558	arg1	system					577:582	the green and highly efficient KOH/urea aqueous system	529:582	the green and highly efficient KOH/urea aqueous system for the first time	529:601	Herein, novel chitin/chitosan composite hydrogels are fabricated from the green and highly efficient KOH/urea aqueous system for the first time.
33458940	10	4	theme	aqueous	1390:1396	arg1	solutions					1407:1415	aqueous KOH/urea solutions	1390:1415	aqueous KOH/urea solutions	1390:1415	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	4	5	theme	composite	489:497	arg1	hydrogels					499:507	novel chitin/chitosan composite hydrogels	467:507	novel chitin/chitosan composite hydrogels	467:507	Herein, novel chitin/chitosan composite hydrogels are fabricated from the green and highly efficient KOH/urea aqueous system for the first time.
33458940	10	6	theme	chitin/chitosan	1289:1303	arg1	materials					1315:1323	novel chitin/chitosan composite materials	1283:1323	novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions	1283:1415	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	10	7	from	dissolution	1352:1362	arg1	solutions					1407:1415	aqueous KOH/urea solutions	1390:1415	aqueous KOH/urea solutions	1390:1415	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	3	8	with	derivative	394:403	arg1	degree					436:441	the acetylation degree	420:441	the acetylation degree lower than 60%	420:456	Chitosan is the most important derivative of chitin with the acetylation degree lower than 60%.
33458940	5	9	theme	KOH/urea	654:661	arg1	solutions					663:671	aqueous KOH/urea solutions	646:671	aqueous KOH/urea solutions	646:671	Both chitin and chitosan are dissolved in aqueous KOH/urea solutions, then cross-linked by epichlorohydrin to form bulk chitin/chitosan composite hydrogels (CCGEL).
33458940	9	10	theme	antibacterial	1193:1205	arg1	activities					1207:1216	antibacterial activities	1193:1216	antibacterial activities	1193:1216	Additionally, the CCGEL samples exhibit antibacterial activities.
33458940	10	11	theme	pioneering	1230:1239	arg1	work					1241:1244	this pioneering work	1225:1244	this pioneering work	1225:1244	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	9	12	theme	CCGEL	1171:1175	arg1	samples					1177:1183	the CCGEL samples	1167:1183	the CCGEL samples	1167:1183	Additionally, the CCGEL samples exhibit antibacterial activities.
33458940	10	13	theme	antibacterial	1485:1497	arg1	fields					1499:1504	antibacterial fields	1485:1504	antibacterial fields	1485:1504	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	7	14	theme	high	987:990	arg1	viability					992:1000	high viability	987:1000	high viability	987:1000	The cell studies show that NIH-3T3 cells self-assemble to form regular 3D multicellular spheroids on the CCGEL samples with high viability.
33458940	7	15	theme	NIH-3T3	890:896	arg1	cells					898:902	NIH-3T3 cells	890:902	NIH-3T3 cells	890:902	The cell studies show that NIH-3T3 cells self-assemble to form regular 3D multicellular spheroids on the CCGEL samples with high viability.
33458940	10	16	from	applications	1448:1459	arg1	culture					1473:1479	the cell culture	1464:1479	the cell culture	1464:1479	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	10	16	from	applications	1448:1459	arg1	fields					1499:1504	antibacterial fields	1485:1504	antibacterial fields	1485:1504	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	10	17	theme	direct	1345:1350	arg1	dissolution					1352:1362	the direct dissolution	1341:1362	the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions	1341:1415	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	1	18	with	polysaccharide	134:147	arg1	bioactivity					175:185	bioactivity	175:185	bioactivity	175:185	Chitin is the second most abundant natural polysaccharide with biocompatibility and bioactivity.
33458940	1	18	with	polysaccharide	134:147	arg1	biocompatibility					154:169	biocompatibility	154:169	biocompatibility	154:169	Chitin is the second most abundant natural polysaccharide with biocompatibility and bioactivity.
33458940	5	19	theme	aqueous	646:652	arg1	solutions					663:671	aqueous KOH/urea solutions	646:671	aqueous KOH/urea solutions	646:671	Both chitin and chitosan are dissolved in aqueous KOH/urea solutions, then cross-linked by epichlorohydrin to form bulk chitin/chitosan composite hydrogels (CCGEL).
33458940	2	20	theme	efficient	298:306	arg1	avenue					308:313	a greener and more efficient avenue	279:313	a greener and more efficient avenue to fabricate chitin-based functional materials	279:360	Aqueous KOH/urea solution is reported for rapid dissolution of chitin, therefore providing a greener and more efficient avenue to fabricate chitin-based functional materials.
33458940	10	21	theme	crucial	1259:1265	arg1	information					1267:1277	crucial information	1259:1277	crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions	1259:1415	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	3	22	theme	important	384:392	arg1	derivative					394:403	the most important derivative	375:403	the most important derivative of chitin with the acetylation degree lower than 60%	375:456	Chitosan is the most important derivative of chitin with the acetylation degree lower than 60%.
33458940	3	22	theme	important	384:392	arg1	Chitosan					363:370	Chitosan	363:370	Chitosan	363:370	Chitosan is the most important derivative of chitin with the acetylation degree lower than 60%.
33458940	0	23	theme	Green	0:4	arg1	Fabrication					6:16	Green Fabrication	0:16	Green Fabrication of Chitin/Chitosan Composite Hydrogels and Their Potential Applications.	0:89	Green Fabrication of Chitin/Chitosan Composite Hydrogels and Their Potential Applications.
33458940	8	24	theme	aggregates	1087:1096	arg1	size					1070:1073	the size	1066:1073	the size of the cell aggregates	1066:1096	L929 cells proliferate and intend to form cell aggregates, and the size of the cell aggregates becomes greater with the increase of chitosan loading.
33458940	3	25	theme	acetylation	424:434	arg1	degree					436:441	the acetylation degree	420:441	the acetylation degree lower than 60%	420:456	Chitosan is the most important derivative of chitin with the acetylation degree lower than 60%.
33458940	4	26	theme	first	592:596	arg1	time					598:601	the first time	588:601	the first time	588:601	Herein, novel chitin/chitosan composite hydrogels are fabricated from the green and highly efficient KOH/urea aqueous system for the first time.
33458940	8	27	theme	cell	1082:1085	arg1	aggregates					1087:1096	the cell aggregates	1078:1096	the cell aggregates	1078:1096	L929 cells proliferate and intend to form cell aggregates, and the size of the cell aggregates becomes greater with the increase of chitosan loading.
33458940	6	28	theme	swelling	810:817	arg1	properties					819:828	The structural, thermal, mechanical, and swelling properties	769:828	The structural, thermal, mechanical, and swelling properties of CCGEL	769:837	The structural, thermal, mechanical, and swelling properties of CCGEL are thoroughly studied.
33458940	2	29	theme	functional	341:350	arg1	materials					352:360	chitin-based functional materials	328:360	chitin-based functional materials	328:360	Aqueous KOH/urea solution is reported for rapid dissolution of chitin, therefore providing a greener and more efficient avenue to fabricate chitin-based functional materials.
33458940	7	30	theme	cell	867:870	arg1	studies					872:878	The cell studies	863:878	The cell studies	863:878	The cell studies show that NIH-3T3 cells self-assemble to form regular 3D multicellular spheroids on the CCGEL samples with high viability.
33458940	3	31	theme	chitin	408:413	arg1	derivative					394:403	the most important derivative	375:403	the most important derivative of chitin with the acetylation degree lower than 60%	375:456	Chitosan is the most important derivative of chitin with the acetylation degree lower than 60%.
33458940	3	31	theme	chitin	408:413	arg1	Chitosan					363:370	Chitosan	363:370	Chitosan	363:370	Chitosan is the most important derivative of chitin with the acetylation degree lower than 60%.
33458940	10	32	theme	cell	1468:1471	arg1	culture					1473:1479	the cell culture	1464:1479	the cell culture	1464:1479	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	6	33	theme	CCGEL	833:837	arg1	properties					819:828	The structural, thermal, mechanical, and swelling properties	769:828	The structural, thermal, mechanical, and swelling properties of CCGEL	769:837	The structural, thermal, mechanical, and swelling properties of CCGEL are thoroughly studied.
33458940	2	34	theme	chitin-based	328:339	arg1	materials					352:360	chitin-based functional materials	328:360	chitin-based functional materials	328:360	Aqueous KOH/urea solution is reported for rapid dissolution of chitin, therefore providing a greener and more efficient avenue to fabricate chitin-based functional materials.
33458940	8	35	theme	cell	1045:1048	arg1	aggregates					1050:1059	cell aggregates	1045:1059	cell aggregates	1045:1059	L929 cells proliferate and intend to form cell aggregates, and the size of the cell aggregates becomes greater with the increase of chitosan loading.
33458940	10	36	theme	chitosan	1378:1385	arg1	dissolution					1352:1362	the direct dissolution	1341:1362	the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions	1341:1415	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	7	37	with	samples	974:980	arg1	viability					992:1000	high viability	987:1000	high viability	987:1000	The cell studies show that NIH-3T3 cells self-assemble to form regular 3D multicellular spheroids on the CCGEL samples with high viability.
33458940	4	38	theme	chitin/chitosan	473:487	arg1	hydrogels					499:507	novel chitin/chitosan composite hydrogels	467:507	novel chitin/chitosan composite hydrogels	467:507	Herein, novel chitin/chitosan composite hydrogels are fabricated from the green and highly efficient KOH/urea aqueous system for the first time.
33458940	0	39	theme	Hydrogels	47:55	arg1	Fabrication					6:16	Green Fabrication	0:16	Green Fabrication of Chitin/Chitosan Composite Hydrogels and Their Potential Applications.	0:89	Green Fabrication of Chitin/Chitosan Composite Hydrogels and Their Potential Applications.
33458940	4	40	theme	novel	467:471	arg1	hydrogels					499:507	novel chitin/chitosan composite hydrogels	467:507	novel chitin/chitosan composite hydrogels	467:507	Herein, novel chitin/chitosan composite hydrogels are fabricated from the green and highly efficient KOH/urea aqueous system for the first time.
33458940	7	41	theme	multicellular	937:949	arg1	spheroids					951:959	regular 3D multicellular spheroids	926:959	regular 3D multicellular spheroids	926:959	The cell studies show that NIH-3T3 cells self-assemble to form regular 3D multicellular spheroids on the CCGEL samples with high viability.
33458940	0	42	theme	Composite	37:45	arg1	Hydrogels					47:55	Chitin/Chitosan Composite Hydrogels	21:55	Chitin/Chitosan Composite Hydrogels	21:55	Green Fabrication of Chitin/Chitosan Composite Hydrogels and Their Potential Applications.
33458940	4	43	theme	aqueous	569:575	arg1	system					577:582	the green and highly efficient KOH/urea aqueous system	529:582	the green and highly efficient KOH/urea aqueous system for the first time	529:601	Herein, novel chitin/chitosan composite hydrogels are fabricated from the green and highly efficient KOH/urea aqueous system for the first time.
33458940	2	44	theme	KOH/urea	196:203	arg1	solution					205:212	Aqueous KOH/urea solution	188:212	Aqueous KOH/urea solution	188:212	Aqueous KOH/urea solution is reported for rapid dissolution of chitin, therefore providing a greener and more efficient avenue to fabricate chitin-based functional materials.
33458940	0	45	theme	Chitin/Chitosan	21:35	arg1	Hydrogels					47:55	Chitin/Chitosan Composite Hydrogels	21:55	Chitin/Chitosan Composite Hydrogels	21:55	Green Fabrication of Chitin/Chitosan Composite Hydrogels and Their Potential Applications.
33458940	10	46	theme	KOH/urea	1398:1405	arg1	solutions					1407:1415	aqueous KOH/urea solutions	1390:1415	aqueous KOH/urea solutions	1390:1415	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	4	47	theme	KOH/urea	560:567	arg1	system					577:582	the green and highly efficient KOH/urea aqueous system	529:582	the green and highly efficient KOH/urea aqueous system for the first time	529:601	Herein, novel chitin/chitosan composite hydrogels are fabricated from the green and highly efficient KOH/urea aqueous system for the first time.
33458940	2	48	theme	Aqueous	188:194	arg1	solution					205:212	Aqueous KOH/urea solution	188:212	Aqueous KOH/urea solution	188:212	Aqueous KOH/urea solution is reported for rapid dissolution of chitin, therefore providing a greener and more efficient avenue to fabricate chitin-based functional materials.
33458940	2	49	theme	chitin	251:256	arg1	dissolution					236:246	rapid dissolution	230:246	rapid dissolution of chitin	230:256	Aqueous KOH/urea solution is reported for rapid dissolution of chitin, therefore providing a greener and more efficient avenue to fabricate chitin-based functional materials.
33458940	6	50	theme	mechanical	794:803	arg1	properties					819:828	The structural, thermal, mechanical, and swelling properties	769:828	The structural, thermal, mechanical, and swelling properties of CCGEL	769:837	The structural, thermal, mechanical, and swelling properties of CCGEL are thoroughly studied.
33458940	1	51	theme	abundant	117:124	arg1	polysaccharide					134:147	the second most abundant natural polysaccharide	101:147	the second most abundant natural polysaccharide with biocompatibility and bioactivity	101:185	Chitin is the second most abundant natural polysaccharide with biocompatibility and bioactivity.
33458940	1	51	theme	abundant	117:124	arg1	Chitin					91:96	Chitin	91:96	Chitin	91:96	Chitin is the second most abundant natural polysaccharide with biocompatibility and bioactivity.
33458940	3	52	theme	lower	443:447	arg1	degree					436:441	the acetylation degree	420:441	the acetylation degree lower than 60%	420:456	Chitosan is the most important derivative of chitin with the acetylation degree lower than 60%.
33458940	5	53	theme	bulk	719:722	arg1	CCGEL					761:765	CCGEL	761:765	CCGEL	761:765	Both chitin and chitosan are dissolved in aqueous KOH/urea solutions, then cross-linked by epichlorohydrin to form bulk chitin/chitosan composite hydrogels (CCGEL).
33458940	5	53	theme	bulk	719:722	arg1	hydrogels					750:758	bulk chitin/chitosan composite hydrogels	719:758	bulk chitin/chitosan composite hydrogels (CCGEL)	719:766	Both chitin and chitosan are dissolved in aqueous KOH/urea solutions, then cross-linked by epichlorohydrin to form bulk chitin/chitosan composite hydrogels (CCGEL).
33458940	1	54	theme	natural	126:132	arg1	polysaccharide					134:147	the second most abundant natural polysaccharide	101:147	the second most abundant natural polysaccharide with biocompatibility and bioactivity	101:185	Chitin is the second most abundant natural polysaccharide with biocompatibility and bioactivity.
33458940	1	54	theme	natural	126:132	arg1	Chitin					91:96	Chitin	91:96	Chitin	91:96	Chitin is the second most abundant natural polysaccharide with biocompatibility and bioactivity.
33458940	7	55	theme	CCGEL	968:972	arg1	samples					974:980	the CCGEL samples	964:980	the CCGEL samples with high viability	964:1000	The cell studies show that NIH-3T3 cells self-assemble to form regular 3D multicellular spheroids on the CCGEL samples with high viability.
33458940	5	56	theme	chitin/chitosan	724:738	arg1	CCGEL					761:765	CCGEL	761:765	CCGEL	761:765	Both chitin and chitosan are dissolved in aqueous KOH/urea solutions, then cross-linked by epichlorohydrin to form bulk chitin/chitosan composite hydrogels (CCGEL).
33458940	5	56	theme	chitin/chitosan	724:738	arg1	hydrogels					750:758	bulk chitin/chitosan composite hydrogels	719:758	bulk chitin/chitosan composite hydrogels (CCGEL)	719:766	Both chitin and chitosan are dissolved in aqueous KOH/urea solutions, then cross-linked by epichlorohydrin to form bulk chitin/chitosan composite hydrogels (CCGEL).
33458940	2	57	theme	rapid	230:234	arg1	dissolution					236:246	rapid dissolution	230:246	rapid dissolution of chitin	230:256	Aqueous KOH/urea solution is reported for rapid dissolution of chitin, therefore providing a greener and more efficient avenue to fabricate chitin-based functional materials.
33458940	6	58	theme	thermal	785:791	arg1	properties					819:828	The structural, thermal, mechanical, and swelling properties	769:828	The structural, thermal, mechanical, and swelling properties of CCGEL	769:837	The structural, thermal, mechanical, and swelling properties of CCGEL are thoroughly studied.
33458940	1	59	theme	second	105:110	arg1	polysaccharide					134:147	the second most abundant natural polysaccharide	101:147	the second most abundant natural polysaccharide with biocompatibility and bioactivity	101:185	Chitin is the second most abundant natural polysaccharide with biocompatibility and bioactivity.
33458940	1	59	theme	second	105:110	arg1	Chitin					91:96	Chitin	91:96	Chitin	91:96	Chitin is the second most abundant natural polysaccharide with biocompatibility and bioactivity.
33458940	5	60	theme	composite	740:748	arg1	CCGEL					761:765	CCGEL	761:765	CCGEL	761:765	Both chitin and chitosan are dissolved in aqueous KOH/urea solutions, then cross-linked by epichlorohydrin to form bulk chitin/chitosan composite hydrogels (CCGEL).
33458940	5	60	theme	composite	740:748	arg1	hydrogels					750:758	bulk chitin/chitosan composite hydrogels	719:758	bulk chitin/chitosan composite hydrogels (CCGEL)	719:766	Both chitin and chitosan are dissolved in aqueous KOH/urea solutions, then cross-linked by epichlorohydrin to form bulk chitin/chitosan composite hydrogels (CCGEL).
33458940	2	61	theme	greener	281:287	arg1	avenue					308:313	a greener and more efficient avenue	279:313	a greener and more efficient avenue to fabricate chitin-based functional materials	279:360	Aqueous KOH/urea solution is reported for rapid dissolution of chitin, therefore providing a greener and more efficient avenue to fabricate chitin-based functional materials.
33458940	8	62	theme	loading	1144:1150	arg1	increase					1123:1130	the increase	1119:1130	the increase of chitosan loading	1119:1150	L929 cells proliferate and intend to form cell aggregates, and the size of the cell aggregates becomes greater with the increase of chitosan loading.
33458940	10	63	theme	chitin	1367:1372	arg1	dissolution					1352:1362	the direct dissolution	1341:1362	the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions	1341:1415	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	7	64	theme	3D	934:935	arg1	spheroids					951:959	regular 3D multicellular spheroids	926:959	regular 3D multicellular spheroids	926:959	The cell studies show that NIH-3T3 cells self-assemble to form regular 3D multicellular spheroids on the CCGEL samples with high viability.
33458940	0	65	theme	Applications	77:88	arg1	Fabrication					6:16	Green Fabrication	0:16	Green Fabrication of Chitin/Chitosan Composite Hydrogels and Their Potential Applications.	0:89	Green Fabrication of Chitin/Chitosan Composite Hydrogels and Their Potential Applications.
33458940	10	66	theme	novel	1283:1287	arg1	materials					1315:1323	novel chitin/chitosan composite materials	1283:1323	novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions	1283:1415	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	6	67	theme	structural	773:782	arg1	properties					819:828	The structural, thermal, mechanical, and swelling properties	769:828	The structural, thermal, mechanical, and swelling properties of CCGEL	769:837	The structural, thermal, mechanical, and swelling properties of CCGEL are thoroughly studied.
33458940	10	68	theme	potential	1438:1446	arg1	applications					1448:1459	their potential applications	1432:1459	their potential applications in the cell culture and antibacterial fields	1432:1504	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33458940	5	69	dep	dissolved	633:641	arg1	cross-linked					679:690	cross-linked	679:690	then cross-linked by epichlorohydrin to form bulk chitin/chitosan composite hydrogels (CCGEL)	674:766	Both chitin and chitosan are dissolved in aqueous KOH/urea solutions, then cross-linked by epichlorohydrin to form bulk chitin/chitosan composite hydrogels (CCGEL).
33458940	0	70	theme	Potential	67:75	arg1	Applications					77:88	Their Potential Applications	61:88	Their Potential Applications	61:88	Green Fabrication of Chitin/Chitosan Composite Hydrogels and Their Potential Applications.
33458940	8	71	theme	L929	1003:1006	arg1	cells					1008:1012	L929 cells	1003:1012	L929 cells	1003:1012	L929 cells proliferate and intend to form cell aggregates, and the size of the cell aggregates becomes greater with the increase of chitosan loading.
33458940	10	72	theme	composite	1305:1313	arg1	materials					1315:1323	novel chitin/chitosan composite materials	1283:1323	novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions	1283:1415	Thus, this pioneering work has provided crucial information for novel chitin/chitosan composite materials constructed via the direct dissolution of chitin and chitosan in aqueous KOH/urea solutions, and presented their potential applications in the cell culture and antibacterial fields.
33720428	4	0	theme	Physcomitrium patens	523:542	arg1	mutants					544:550	Physcomitrium patens mutants	523:550	Physcomitrium patens mutants for the LCB C-4 hydroxylase S4H	523:582	Physcomitrium patens mutants for the LCB C-4 hydroxylase S4H were generated by homologous recombination.
33720428	8	1	theme	growth	1000:1005	arg1	defects					1007:1013	growth defects	1000:1013	growth defects	1000:1013	Changes in membrane lipid composition may trigger growth defects by interfering with the localisation of membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes.
33720428	1	2	theme	plasma	171:176	arg1	PM					188:189	PM	188:189	PM	188:189	Sphingolipids are enriched in microdomains in the plant plasma membrane (PM).
33720428	1	2	theme	plasma	171:176	arg1	membrane					178:185	the plant plasma membrane	161:185	the plant plasma membrane (PM)	161:190	Sphingolipids are enriched in microdomains in the plant plasma membrane (PM).
33720428	5	3	theme	SG	708:709	arg1	profiles					712:719	their sphingolipid and steryl glycoside (SG) profiles	667:719	their sphingolipid and steryl glycoside (SG) profiles	667:719	Plants were characterised by analysing their sphingolipid and steryl glycoside (SG) profiles and by investigating different gametophyte stages.
33720428	7	4	theme	moss	906:909	arg1	sphingolipidome					911:925	the moss sphingolipidome	902:925	the moss sphingolipidome	902:925	Loss of this hydroxyl group caused global changes in the moss sphingolipidome and in SG composition.
33720428	2	5	from	groups	202:207	arg1	moiety					253:258	the characteristic long-chain base (LCB) moiety	212:258	the characteristic long-chain base (LCB) moiety	212:258	Hydroxyl groups in the characteristic long-chain base (LCB) moiety might be essential for the interaction between sphingolipids and sterols during microdomain formation.
33720428	3	6	theme	hydroxylase	381:391	arg1	mutants					393:399	LCB hydroxylase mutants	377:399	LCB hydroxylase mutants in Physcomitrium patens	377:423	Investigating LCB hydroxylase mutants in Physcomitrium patens might therefore reveal the role of certain plant sphingolipids in the formation of PM subdomains.
33720428	3	7	from	mutants	393:399	arg1	patens					418:423	Physcomitrium patens	404:423	Physcomitrium patens	404:423	Investigating LCB hydroxylase mutants in Physcomitrium patens might therefore reveal the role of certain plant sphingolipids in the formation of PM subdomains.
33720428	9	8	theme	key	1276:1278	arg1	role					1280:1283	a key role	1274:1283	a key role for S4H during development of nonvascular plants	1274:1332	Loss of LCB-C4 hydroxylation substantially changes the P. patens sphingolipidome and reveals a key role for S4H during development of nonvascular plants.
33720428	6	9	theme	s4h	772:774	arg1	mutants					776:782	s4h mutants	772:782	s4h mutants	772:782	s4h mutants lost the hydroxyl group at the C-4 position of their LCB moiety.
33720428	0	10	from	growth	60:65	arg1	patens					107:112	Physcomitrium patens	93:112	Physcomitrium patens	93:112	Sphingolipid long-chain base hydroxylation influences plant growth and callose deposition in Physcomitrium patens.
33720428	5	11	theme	sphingolipid	673:684	arg1	profiles					712:719	their sphingolipid and steryl glycoside (SG) profiles	667:719	their sphingolipid and steryl glycoside (SG) profiles	667:719	Plants were characterised by analysing their sphingolipid and steryl glycoside (SG) profiles and by investigating different gametophyte stages.
33720428	6	12	theme	moiety	841:846	arg1	position					819:826	the C-4 position	811:826	the C-4 position of their LCB moiety	811:846	s4h mutants lost the hydroxyl group at the C-4 position of their LCB moiety.
33720428	7	13	theme	SG	934:935	arg1	composition					937:947	SG composition	934:947	SG composition	934:947	Loss of this hydroxyl group caused global changes in the moss sphingolipidome and in SG composition.
33720428	3	14	theme	certain	460:466	arg1	sphingolipids					474:486	certain plant sphingolipids	460:486	certain plant sphingolipids	460:486	Investigating LCB hydroxylase mutants in Physcomitrium patens might therefore reveal the role of certain plant sphingolipids in the formation of PM subdomains.
33720428	11	15	theme	biological	1521:1530	arg1	membranes					1532:1540	biological membranes	1521:1540	biological membranes	1521:1540	The simple anatomy of P. patens facilitates visualisation of physiological processes in biological membranes.
33720428	8	16	theme	growth	1105:1110	arg1	processes					1112:1120	growth processes	1105:1120	growth processes such as signalling receptors or callose-modifying enzymes	1105:1178	Changes in membrane lipid composition may trigger growth defects by interfering with the localisation of membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes.
33720428	8	16	theme	growth	1105:1110	arg1	receptors					1141:1149	signalling receptors	1130:1149	signalling receptors	1130:1149	Changes in membrane lipid composition may trigger growth defects by interfering with the localisation of membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes.
33720428	8	16	theme	growth	1105:1110	arg1	enzymes					1172:1178	callose-modifying enzymes	1154:1178	callose-modifying enzymes	1154:1178	Changes in membrane lipid composition may trigger growth defects by interfering with the localisation of membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes.
33720428	1	17	from	microdomains	145:156	arg1	PM					188:189	PM	188:189	PM	188:189	Sphingolipids are enriched in microdomains in the plant plasma membrane (PM).
33720428	1	17	from	microdomains	145:156	arg1	membrane					178:185	the plant plasma membrane	161:185	the plant plasma membrane (PM)	161:190	Sphingolipids are enriched in microdomains in the plant plasma membrane (PM).
33720428	11	18	theme	simple	1437:1442	arg1	anatomy					1444:1450	The simple anatomy	1433:1450	The simple anatomy of P. patens	1433:1463	The simple anatomy of P. patens facilitates visualisation of physiological processes in biological membranes.
33720428	7	19	theme	global	884:889	arg1	changes					891:897	global changes	884:897	global changes	884:897	Loss of this hydroxyl group caused global changes in the moss sphingolipidome and in SG composition.
33720428	3	20	theme	plant	468:472	arg1	sphingolipids					474:486	certain plant sphingolipids	460:486	certain plant sphingolipids	460:486	Investigating LCB hydroxylase mutants in Physcomitrium patens might therefore reveal the role of certain plant sphingolipids in the formation of PM subdomains.
33720428	0	21	theme	long-chain	13:22	arg1	hydroxylation					29:41	Sphingolipid long-chain base hydroxylation	0:41	Sphingolipid long-chain base hydroxylation	0:41	Sphingolipid long-chain base hydroxylation influences plant growth and callose deposition in Physcomitrium patens.
33720428	5	22	theme	steryl	690:695	arg1	profiles					712:719	their sphingolipid and steryl glycoside (SG) profiles	667:719	their sphingolipid and steryl glycoside (SG) profiles	667:719	Plants were characterised by analysing their sphingolipid and steryl glycoside (SG) profiles and by investigating different gametophyte stages.
33720428	10	23	theme	valuable	1361:1368	arg1	patens					1349:1354	Physcomitrium patens	1335:1354	Physcomitrium patens	1335:1354	Physcomitrium patens is a valuable model for studying the diversification of plant sphingolipids.
33720428	10	23	theme	valuable	1361:1368	arg1	model					1370:1374	a valuable model	1359:1374	a valuable model for studying the diversification of plant sphingolipids	1359:1430	Physcomitrium patens is a valuable model for studying the diversification of plant sphingolipids.
33720428	0	24	theme	Sphingolipid	0:11	arg1	hydroxylation					29:41	Sphingolipid long-chain base hydroxylation	0:41	Sphingolipid long-chain base hydroxylation	0:41	Sphingolipid long-chain base hydroxylation influences plant growth and callose deposition in Physcomitrium patens.
33720428	5	25	theme	glycoside	697:705	arg1	profiles					712:719	their sphingolipid and steryl glycoside (SG) profiles	667:719	their sphingolipid and steryl glycoside (SG) profiles	667:719	Plants were characterised by analysing their sphingolipid and steryl glycoside (SG) profiles and by investigating different gametophyte stages.
33720428	8	26	theme	proteins	1075:1082	arg1	localisation					1039:1050	the localisation	1035:1050	the localisation of membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes	1035:1178	Changes in membrane lipid composition may trigger growth defects by interfering with the localisation of membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes.
33720428	7	27	theme	group	871:875	arg1	Loss					849:852	Loss	849:852	Loss of this hydroxyl group	849:875	Loss of this hydroxyl group caused global changes in the moss sphingolipidome and in SG composition.
33720428	6	28	theme	hydroxyl	793:800	arg1	group					802:806	the hydroxyl group	789:806	the hydroxyl group	789:806	s4h mutants lost the hydroxyl group at the C-4 position of their LCB moiety.
33720428	5	29	theme	gametophyte	752:762	arg1	stages					764:769	different gametophyte stages	742:769	different gametophyte stages	742:769	Plants were characterised by analysing their sphingolipid and steryl glycoside (SG) profiles and by investigating different gametophyte stages.
33720428	8	30	theme	membrane-associated	1055:1073	arg1	proteins					1075:1082	membrane-associated proteins	1055:1082	membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes	1055:1178	Changes in membrane lipid composition may trigger growth defects by interfering with the localisation of membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes.
33720428	9	31	theme	LCB-C4	1189:1194	arg1	hydroxylation					1196:1208	LCB-C4 hydroxylation	1189:1208	LCB-C4 hydroxylation	1189:1208	Loss of LCB-C4 hydroxylation substantially changes the P. patens sphingolipidome and reveals a key role for S4H during development of nonvascular plants.
33720428	0	32	theme	base	24:27	arg1	hydroxylation					29:41	Sphingolipid long-chain base hydroxylation	0:41	Sphingolipid long-chain base hydroxylation	0:41	Sphingolipid long-chain base hydroxylation influences plant growth and callose deposition in Physcomitrium patens.
33720428	4	33	theme	homologous	602:611	arg1	recombination					613:625	homologous recombination	602:625	homologous recombination	602:625	Physcomitrium patens mutants for the LCB C-4 hydroxylase S4H were generated by homologous recombination.
33720428	8	34	theme	signalling	1130:1139	arg1	receptors					1141:1149	signalling receptors	1130:1149	signalling receptors	1130:1149	Changes in membrane lipid composition may trigger growth defects by interfering with the localisation of membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes.
33720428	10	35	theme	plant	1412:1416	arg1	sphingolipids					1418:1430	plant sphingolipids	1412:1430	plant sphingolipids	1412:1430	Physcomitrium patens is a valuable model for studying the diversification of plant sphingolipids.
33720428	0	36	theme	plant	54:58	arg1	growth					60:65	plant growth	54:65	plant growth	54:65	Sphingolipid long-chain base hydroxylation influences plant growth and callose deposition in Physcomitrium patens.
33720428	8	37	theme	callose-modifying	1154:1170	arg1	enzymes					1172:1178	callose-modifying enzymes	1154:1178	callose-modifying enzymes	1154:1178	Changes in membrane lipid composition may trigger growth defects by interfering with the localisation of membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes.
33720428	9	38	theme	nonvascular	1315:1325	arg1	plants					1327:1332	nonvascular plants	1315:1332	nonvascular plants	1315:1332	Loss of LCB-C4 hydroxylation substantially changes the P. patens sphingolipidome and reveals a key role for S4H during development of nonvascular plants.
33720428	7	39	theme	hydroxyl	862:869	arg1	group					871:875	this hydroxyl group	857:875	this hydroxyl group	857:875	Loss of this hydroxyl group caused global changes in the moss sphingolipidome and in SG composition.
33720428	3	40	theme	sphingolipids	474:486	arg1	role					452:455	the role	448:455	the role of certain plant sphingolipids in the formation of PM subdomains	448:520	Investigating LCB hydroxylase mutants in Physcomitrium patens might therefore reveal the role of certain plant sphingolipids in the formation of PM subdomains.
33720428	4	41	theme	C-4	564:566	arg1	S4H					580:582	the LCB C-4 hydroxylase S4H	556:582	the LCB C-4 hydroxylase S4H	556:582	Physcomitrium patens mutants for the LCB C-4 hydroxylase S4H were generated by homologous recombination.
33720428	9	42	theme	plants	1327:1332	arg1	development					1300:1310	development	1300:1310	development of nonvascular plants	1300:1332	Loss of LCB-C4 hydroxylation substantially changes the P. patens sphingolipidome and reveals a key role for S4H during development of nonvascular plants.
33720428	0	43	from	deposition	79:88	arg1	patens					107:112	Physcomitrium patens	93:112	Physcomitrium patens	93:112	Sphingolipid long-chain base hydroxylation influences plant growth and callose deposition in Physcomitrium patens.
33720428	2	44	theme	base	242:245	arg1	moiety					253:258	the characteristic long-chain base (LCB) moiety	212:258	the characteristic long-chain base (LCB) moiety	212:258	Hydroxyl groups in the characteristic long-chain base (LCB) moiety might be essential for the interaction between sphingolipids and sterols during microdomain formation.
33720428	6	45	theme	C-4	815:817	arg1	position					819:826	the C-4 position	811:826	the C-4 position of their LCB moiety	811:846	s4h mutants lost the hydroxyl group at the C-4 position of their LCB moiety.
33720428	11	46	theme	P. patens	1455:1463	arg1	anatomy					1444:1450	The simple anatomy	1433:1450	The simple anatomy of P. patens	1433:1463	The simple anatomy of P. patens facilitates visualisation of physiological processes in biological membranes.
33720428	3	47	theme	LCB	377:379	arg1	mutants					393:399	LCB hydroxylase mutants	377:399	LCB hydroxylase mutants in Physcomitrium patens	377:423	Investigating LCB hydroxylase mutants in Physcomitrium patens might therefore reveal the role of certain plant sphingolipids in the formation of PM subdomains.
33720428	11	48	theme	processes	1508:1516	arg1	visualisation					1477:1489	visualisation	1477:1489	visualisation of physiological processes in biological membranes	1477:1540	The simple anatomy of P. patens facilitates visualisation of physiological processes in biological membranes.
33720428	2	49	theme	long-chain	231:240	arg1	moiety					253:258	the characteristic long-chain base (LCB) moiety	212:258	the characteristic long-chain base (LCB) moiety	212:258	Hydroxyl groups in the characteristic long-chain base (LCB) moiety might be essential for the interaction between sphingolipids and sterols during microdomain formation.
33720428	9	50	theme	hydroxylation	1196:1208	arg1	Loss					1181:1184	Loss	1181:1184	Loss of LCB-C4 hydroxylation	1181:1208	Loss of LCB-C4 hydroxylation substantially changes the P. patens sphingolipidome and reveals a key role for S4H during development of nonvascular plants.
33720428	3	51	theme	subdomains	511:520	arg1	formation					495:503	the formation	491:503	the formation of PM subdomains	491:520	Investigating LCB hydroxylase mutants in Physcomitrium patens might therefore reveal the role of certain plant sphingolipids in the formation of PM subdomains.
33720428	11	52	from	visualisation	1477:1489	arg1	membranes					1532:1540	biological membranes	1521:1540	biological membranes	1521:1540	The simple anatomy of P. patens facilitates visualisation of physiological processes in biological membranes.
33720428	2	53	theme	characteristic	216:229	arg1	moiety					253:258	the characteristic long-chain base (LCB) moiety	212:258	the characteristic long-chain base (LCB) moiety	212:258	Hydroxyl groups in the characteristic long-chain base (LCB) moiety might be essential for the interaction between sphingolipids and sterols during microdomain formation.
33720428	2	54	theme	microdomain	340:350	arg1	formation					352:360	microdomain formation	340:360	microdomain formation	340:360	Hydroxyl groups in the characteristic long-chain base (LCB) moiety might be essential for the interaction between sphingolipids and sterols during microdomain formation.
33720428	4	55	theme	hydroxylase	568:578	arg1	S4H					580:582	the LCB C-4 hydroxylase S4H	556:582	the LCB C-4 hydroxylase S4H	556:582	Physcomitrium patens mutants for the LCB C-4 hydroxylase S4H were generated by homologous recombination.
33720428	6	56	theme	LCB	837:839	arg1	moiety					841:846	their LCB moiety	831:846	their LCB moiety	831:846	s4h mutants lost the hydroxyl group at the C-4 position of their LCB moiety.
33720428	8	57	from	Changes	950:956	arg1	composition					976:986	membrane lipid composition	961:986	membrane lipid composition	961:986	Changes in membrane lipid composition may trigger growth defects by interfering with the localisation of membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes.
33720428	8	58	theme	lipid	970:974	arg1	composition					976:986	membrane lipid composition	961:986	membrane lipid composition	961:986	Changes in membrane lipid composition may trigger growth defects by interfering with the localisation of membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes.
33720428	5	59	theme	different	742:750	arg1	stages					764:769	different gametophyte stages	742:769	different gametophyte stages	742:769	Plants were characterised by analysing their sphingolipid and steryl glycoside (SG) profiles and by investigating different gametophyte stages.
33720428	8	60	theme	membrane	961:968	arg1	composition					976:986	membrane lipid composition	961:986	membrane lipid composition	961:986	Changes in membrane lipid composition may trigger growth defects by interfering with the localisation of membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes.
33720428	3	61	from	role	452:455	arg1	formation					495:503	the formation	491:503	the formation of PM subdomains	491:520	Investigating LCB hydroxylase mutants in Physcomitrium patens might therefore reveal the role of certain plant sphingolipids in the formation of PM subdomains.
33720428	3	62	theme	PM	508:509	arg1	subdomains					511:520	PM subdomains	508:520	PM subdomains	508:520	Investigating LCB hydroxylase mutants in Physcomitrium patens might therefore reveal the role of certain plant sphingolipids in the formation of PM subdomains.
33720428	5	63	dep	characterised	640:652	arg1	investigating					728:740	investigating	728:740	investigating different gametophyte stages	728:769	Plants were characterised by analysing their sphingolipid and steryl glycoside (SG) profiles and by investigating different gametophyte stages.
33720428	5	63	dep	characterised	640:652	arg1	analysing					657:665	analysing	657:665	analysing their sphingolipid and steryl glycoside (SG) profiles	657:719	Plants were characterised by analysing their sphingolipid and steryl glycoside (SG) profiles and by investigating different gametophyte stages.
33720428	10	64	theme	sphingolipids	1418:1430	arg1	diversification					1393:1407	the diversification	1389:1407	the diversification of plant sphingolipids	1389:1430	Physcomitrium patens is a valuable model for studying the diversification of plant sphingolipids.
33720428	11	65	theme	physiological	1494:1506	arg1	processes					1508:1516	physiological processes	1494:1516	physiological processes	1494:1516	The simple anatomy of P. patens facilitates visualisation of physiological processes in biological membranes.
33720428	2	66	theme	Hydroxyl	193:200	arg1	groups					202:207	Hydroxyl groups	193:207	Hydroxyl groups in the characteristic long-chain base (LCB) moiety	193:258	Hydroxyl groups in the characteristic long-chain base (LCB) moiety might be essential for the interaction between sphingolipids and sterols during microdomain formation.
33720428	9	67	theme	P. patens	1236:1244	arg1	sphingolipidome					1246:1260	the P. patens sphingolipidome	1232:1260	the P. patens sphingolipidome	1232:1260	Loss of LCB-C4 hydroxylation substantially changes the P. patens sphingolipidome and reveals a key role for S4H during development of nonvascular plants.
33720428	0	68	theme	callose	71:77	arg1	deposition					79:88	callose deposition	71:88	callose deposition	71:88	Sphingolipid long-chain base hydroxylation influences plant growth and callose deposition in Physcomitrium patens.
33720428	2	69	theme	LCB	248:250	arg1	moiety					253:258	the characteristic long-chain base (LCB) moiety	212:258	the characteristic long-chain base (LCB) moiety	212:258	Hydroxyl groups in the characteristic long-chain base (LCB) moiety might be essential for the interaction between sphingolipids and sterols during microdomain formation.
33720428	1	70	theme	plant	165:169	arg1	PM					188:189	PM	188:189	PM	188:189	Sphingolipids are enriched in microdomains in the plant plasma membrane (PM).
33720428	1	70	theme	plant	165:169	arg1	membrane					178:185	the plant plasma membrane	161:185	the plant plasma membrane (PM)	161:190	Sphingolipids are enriched in microdomains in the plant plasma membrane (PM).
33720428	4	71	theme	LCB	560:562	arg1	S4H					580:582	the LCB C-4 hydroxylase S4H	556:582	the LCB C-4 hydroxylase S4H	556:582	Physcomitrium patens mutants for the LCB C-4 hydroxylase S4H were generated by homologous recombination.
34142427	4	0	theme	stress	707:712	arg1	state					714:718	the stress state	703:718	the stress state	703:718	A software-based quantitative assessment is performed to evaluate the stress state at wound sites, which confirms that the composite gel adapted in vivo to wound stress and ultimately promotes fast wound healing.
34142427	2	1	from	sites	391:395	arg1	stress					375:380	stress	375:380	stress at wound sites	375:395	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	2	2	theme	wound	335:339	arg1	healing					341:347	a skin wound healing	328:347	a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network	328:474	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	0	3	theme	Interstitium	85:96	arg1	Reconstruction					62:75	Local Stress-Responsive Reconstruction	38:75	Local Stress-Responsive Reconstruction of Skin Interstitium	38:96	In Situ Self-Organizing Materials for Local Stress-Responsive Reconstruction of Skin Interstitium.
34142427	5	4	theme	interstitial	890:901	arg1	reconstruction					903:916	interstitial reconstruction	890:916	interstitial reconstruction	890:916	The results highlight the importance of interstitial reconstruction in tissue recovery, and will inspire novel strategies in regenerative medicine.
34142427	2	5	theme	skin	330:333	arg1	healing					341:347	a skin wound healing	328:347	a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network	328:474	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	5	6	from	strategies	961:970	arg1	medicine					988:995	regenerative medicine	975:995	regenerative medicine	975:995	The results highlight the importance of interstitial reconstruction in tissue recovery, and will inspire novel strategies in regenerative medicine.
34142427	4	7	theme	composite	760:768	arg1	gel					770:772	the composite gel	756:772	the composite gel	756:772	A software-based quantitative assessment is performed to evaluate the stress state at wound sites, which confirms that the composite gel adapted in vivo to wound stress and ultimately promotes fast wound healing.
34142427	1	8	theme	fibrous	117:123	arg1	network					125:131	the fibrous network	113:131	the fibrous network	113:131	Remodeling of the fibrous network in the skin interstitium is a crucial step in the process of skin wound healing.
34142427	1	9	theme	crucial	163:169	arg1	step					171:174	a crucial step	161:174	a crucial step in the process of skin wound healing	161:211	Remodeling of the fibrous network in the skin interstitium is a crucial step in the process of skin wound healing.
34142427	1	9	theme	crucial	163:169	arg1	Remodeling					99:108	Remodeling	99:108	Remodeling of the fibrous network in the skin interstitium	99:156	Remodeling of the fibrous network in the skin interstitium is a crucial step in the process of skin wound healing.
34142427	5	10	from	importance	876:885	arg1	recovery					928:935	tissue recovery	921:935	tissue recovery	921:935	The results highlight the importance of interstitial reconstruction in tissue recovery, and will inspire novel strategies in regenerative medicine.
34142427	2	11	theme	gum-chitosan	272:283	arg1	material					349:356	a skin wound healing material	328:356	a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network	328:474	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	2	11	theme	gum-chitosan	272:283	arg1	hydrogel					303:310	a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel	236:310	a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel	236:310	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	4	12	theme	wound	723:727	arg1	sites					729:733	wound sites	723:733	wound sites	723:733	A software-based quantitative assessment is performed to evaluate the stress state at wound sites, which confirms that the composite gel adapted in vivo to wound stress and ultimately promotes fast wound healing.
34142427	4	13	theme	wound	835:839	arg1	healing					841:847	fast wound healing	830:847	fast wound healing	830:847	A software-based quantitative assessment is performed to evaluate the stress state at wound sites, which confirms that the composite gel adapted in vivo to wound stress and ultimately promotes fast wound healing.
34142427	2	14	theme	xanthan	264:270	arg1	material					349:356	a skin wound healing material	328:356	a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network	328:474	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	2	14	theme	xanthan	264:270	arg1	hydrogel					303:310	a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel	236:310	a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel	236:310	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	2	15	theme	self-repairing	428:441	arg1	network					468:474	the interstitial fibrous network	443:474	in situ self-organizing and self-repairing the interstitial fibrous network	400:474	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	5	16	theme	reconstruction	903:916	arg1	importance					876:885	the importance	872:885	the importance of interstitial reconstruction in tissue recovery	872:935	The results highlight the importance of interstitial reconstruction in tissue recovery, and will inspire novel strategies in regenerative medicine.
34142427	2	17	theme	fibrous	460:466	arg1	network					468:474	the interstitial fibrous network	443:474	in situ self-organizing and self-repairing the interstitial fibrous network	400:474	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	2	18	theme	structured	253:262	arg1	material					349:356	a skin wound healing material	328:356	a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network	328:474	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	2	18	theme	structured	253:262	arg1	hydrogel					303:310	a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel	236:310	a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel	236:310	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	4	19	theme	quantitative	654:665	arg1	assessment					667:676	A software-based quantitative assessment	637:676	A software-based quantitative assessment	637:676	A software-based quantitative assessment is performed to evaluate the stress state at wound sites, which confirms that the composite gel adapted in vivo to wound stress and ultimately promotes fast wound healing.
34142427	3	20	theme	interstitial	551:562	arg1	pathway					564:570	an intact interstitial pathway	541:570	an intact interstitial pathway	541:570	The composite gel adheres tightly to the injured fibers forming an intact interstitial pathway, and thereby promotes the physiological function of fibroblasts.
34142427	4	21	theme	software-based	639:652	arg1	assessment					667:676	A software-based quantitative assessment	637:676	A software-based quantitative assessment	637:676	A software-based quantitative assessment is performed to evaluate the stress state at wound sites, which confirms that the composite gel adapted in vivo to wound stress and ultimately promotes fast wound healing.
34142427	0	22	theme	In	0:1	arg1	Materials					24:32	In Situ Self-Organizing Materials	0:32	In Situ Self-Organizing Materials	0:32	In Situ Self-Organizing Materials for Local Stress-Responsive Reconstruction of Skin Interstitium.
34142427	3	23	theme	intact	544:549	arg1	pathway					564:570	an intact interstitial pathway	541:570	an intact interstitial pathway	541:570	The composite gel adheres tightly to the injured fibers forming an intact interstitial pathway, and thereby promotes the physiological function of fibroblasts.
34142427	2	24	theme	composite	293:301	arg1	material					349:356	a skin wound healing material	328:356	a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network	328:474	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	2	24	theme	composite	293:301	arg1	hydrogel					303:310	a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel	236:310	a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel	236:310	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	0	25	theme	Self-Organizing	8:22	arg1	Materials					24:32	In Situ Self-Organizing Materials	0:32	In Situ Self-Organizing Materials	0:32	In Situ Self-Organizing Materials for Local Stress-Responsive Reconstruction of Skin Interstitium.
34142427	2	26	theme	self-organizing	408:422	arg1	network					468:474	the interstitial fibrous network	443:474	in situ self-organizing and self-repairing the interstitial fibrous network	400:474	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	2	27	theme	XG-CS	286:290	arg1	material					349:356	a skin wound healing material	328:356	a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network	328:474	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	2	27	theme	XG-CS	286:290	arg1	hydrogel					303:310	a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel	236:310	a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel	236:310	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	1	28	theme	skin	194:197	arg1	healing					205:211	skin wound healing	194:211	skin wound healing	194:211	Remodeling of the fibrous network in the skin interstitium is a crucial step in the process of skin wound healing.
34142427	0	29	theme	Local	38:42	arg1	Reconstruction					62:75	Local Stress-Responsive Reconstruction	38:75	Local Stress-Responsive Reconstruction of Skin Interstitium	38:96	In Situ Self-Organizing Materials for Local Stress-Responsive Reconstruction of Skin Interstitium.
34142427	5	30	theme	tissue	921:926	arg1	recovery					928:935	tissue recovery	921:935	tissue recovery	921:935	The results highlight the importance of interstitial reconstruction in tissue recovery, and will inspire novel strategies in regenerative medicine.
34142427	2	31	theme	wound	385:389	arg1	sites					391:395	wound sites	385:395	wound sites	385:395	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	2	32	theme	present	221:227	arg1	study					229:233	the present study	217:233	the present study	217:233	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	1	33	theme	wound	199:203	arg1	healing					205:211	skin wound healing	194:211	skin wound healing	194:211	Remodeling of the fibrous network in the skin interstitium is a crucial step in the process of skin wound healing.
34142427	2	34	theme	interstitial	447:458	arg1	network					468:474	the interstitial fibrous network	443:474	in situ self-organizing and self-repairing the interstitial fibrous network	400:474	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	3	35	theme	fibroblasts	624:634	arg1	function					612:619	the physiological function	594:619	the physiological function of fibroblasts	594:634	The composite gel adheres tightly to the injured fibers forming an intact interstitial pathway, and thereby promotes the physiological function of fibroblasts.
34142427	1	36	theme	healing	205:211	arg1	process					183:189	the process	179:189	the process of skin wound healing	179:211	Remodeling of the fibrous network in the skin interstitium is a crucial step in the process of skin wound healing.
34142427	1	37	theme	network	125:131	arg1	step					171:174	a crucial step	161:174	a crucial step in the process of skin wound healing	161:211	Remodeling of the fibrous network in the skin interstitium is a crucial step in the process of skin wound healing.
34142427	1	37	theme	network	125:131	arg1	Remodeling					99:108	Remodeling	99:108	Remodeling of the fibrous network in the skin interstitium	99:156	Remodeling of the fibrous network in the skin interstitium is a crucial step in the process of skin wound healing.
34142427	0	38	theme	Stress-Responsive	44:60	arg1	Reconstruction					62:75	Local Stress-Responsive Reconstruction	38:75	Local Stress-Responsive Reconstruction of Skin Interstitium	38:96	In Situ Self-Organizing Materials for Local Stress-Responsive Reconstruction of Skin Interstitium.
34142427	4	39	theme	fast	830:833	arg1	healing					841:847	fast wound healing	830:847	fast wound healing	830:847	A software-based quantitative assessment is performed to evaluate the stress state at wound sites, which confirms that the composite gel adapted in vivo to wound stress and ultimately promotes fast wound healing.
34142427	2	40	dep	in	400:401	arg1	situ					403:406	situ	403:406	situ	403:406	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	3	41	theme	composite	481:489	arg1	gel					491:493	The composite gel	477:493	The composite gel	477:493	The composite gel adheres tightly to the injured fibers forming an intact interstitial pathway, and thereby promotes the physiological function of fibroblasts.
34142427	4	42	from	sites	729:733	arg1	state					714:718	the stress state	703:718	the stress state	703:718	A software-based quantitative assessment is performed to evaluate the stress state at wound sites, which confirms that the composite gel adapted in vivo to wound stress and ultimately promotes fast wound healing.
34142427	3	43	theme	physiological	598:610	arg1	function					612:619	the physiological function	594:619	the physiological function of fibroblasts	594:634	The composite gel adheres tightly to the injured fibers forming an intact interstitial pathway, and thereby promotes the physiological function of fibroblasts.
34142427	3	44	theme	injured	518:524	arg1	fibers					526:531	the injured fibers	514:531	the injured fibers forming an intact interstitial pathway	514:570	The composite gel adheres tightly to the injured fibers forming an intact interstitial pathway, and thereby promotes the physiological function of fibroblasts.
34142427	1	45	theme	skin	140:143	arg1	interstitium					145:156	the skin interstitium	136:156	the skin interstitium	136:156	Remodeling of the fibrous network in the skin interstitium is a crucial step in the process of skin wound healing.
34142427	1	46	from	Remodeling	99:108	arg1	interstitium					145:156	the skin interstitium	136:156	the skin interstitium	136:156	Remodeling of the fibrous network in the skin interstitium is a crucial step in the process of skin wound healing.
34142427	0	47	theme	Skin	80:83	arg1	Interstitium					85:96	Skin Interstitium	80:96	Skin Interstitium	80:96	In Situ Self-Organizing Materials for Local Stress-Responsive Reconstruction of Skin Interstitium.
34142427	5	48	theme	regenerative	975:986	arg1	medicine					988:995	regenerative medicine	975:995	regenerative medicine	975:995	The results highlight the importance of interstitial reconstruction in tissue recovery, and will inspire novel strategies in regenerative medicine.
34142427	4	49	theme	wound	793:797	arg1	stress					799:804	wound stress	793:804	wound stress	793:804	A software-based quantitative assessment is performed to evaluate the stress state at wound sites, which confirms that the composite gel adapted in vivo to wound stress and ultimately promotes fast wound healing.
34142427	2	50	theme	in	400:401	arg1	network					468:474	the interstitial fibrous network	443:474	in situ self-organizing and self-repairing the interstitial fibrous network	400:474	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	5	51	theme	novel	955:959	arg1	strategies					961:970	novel strategies	955:970	novel strategies in regenerative medicine	955:995	The results highlight the importance of interstitial reconstruction in tissue recovery, and will inspire novel strategies in regenerative medicine.
34142427	0	52	dep	In	0:1	arg1	Situ					3:6	Situ	3:6	Situ	3:6	In Situ Self-Organizing Materials for Local Stress-Responsive Reconstruction of Skin Interstitium.
34142427	1	53	from	step	171:174	arg1	process					183:189	the process	179:189	the process of skin wound healing	179:211	Remodeling of the fibrous network in the skin interstitium is a crucial step in the process of skin wound healing.
34142427	2	54	theme	healing	341:347	arg1	hydrogel					303:310	a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel	236:310	a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel	236:310	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
34142427	2	54	theme	healing	341:347	arg1	material					349:356	a skin wound healing material	328:356	a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network	328:474	In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network.
32764939	12	0	theme	accessible	2005:2014	arg1	mobility					2016:2023	accessible mobility	2005:2023	accessible mobility of molecular exchange required for improving chronic wound healing	2005:2090	DISCUSSION The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing.
32764939	6	1	theme	NP-based	1014:1021	arg1	alginates					1023:1031	the 3D printed ZnO NP-based alginates	995:1031	the 3D printed ZnO NP-based alginates	995:1031	Envisioning an in-vivo application for the 3D printed ZnO NP-based alginates, we studied their antibacterial properties by bacterial broth testing, cytocompatibility via live/dead assay, and moisture retention capabilities utilizing a humidity sensor.
32764939	3	2	theme	NPs	495:497	arg1	property					475:482	The antibacterial property	457:482	METHODS The antibacterial property of the ZnO NPs	449:497	METHODS The antibacterial property of the ZnO NPs was confirmed by hydroxyl radical generation using ultraviolet (U.V.) photocatalysis.
32764939	9	3	theme	Bacterial	1476:1484	arg1	testing					1497:1503	Bacterial resistance testing	1476:1503	Bacterial resistance testing on Staphylococcus epidermidis	1476:1533	Bacterial resistance testing on Staphylococcus epidermidis indicated the addition of ZnO NPs to the gels decreased bacterial growth when compared to the alginate only gels.
32764939	6	4	theme	retention	1156:1164	arg1	capabilities					1166:1177	moisture retention capabilities	1147:1177	moisture retention capabilities utilizing a humidity sensor	1147:1205	Envisioning an in-vivo application for the 3D printed ZnO NP-based alginates, we studied their antibacterial properties by bacterial broth testing, cytocompatibility via live/dead assay, and moisture retention capabilities utilizing a humidity sensor.
32764939	4	5	theme	Titanium	585:592	arg1	control					670:676	a positive control	659:676	a positive control (1% w/v)	659:685	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	4	5	theme	Titanium	585:592	arg1	TiO2					603:606	TiO2	603:606	TiO2	603:606	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	4	5	theme	Titanium	585:592	arg1	compound					637:644	a well-known antibacterial compound	610:644	a well-known antibacterial compound	610:644	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	4	5	theme	Titanium	585:592	arg1	dioxide					594:600	Titanium dioxide	585:600	Titanium dioxide (TiO2)	585:607	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	13	6	theme	antibacterial	2148:2160	arg1	option					2172:2177	a cost-effective and durable antibacterial treatment option	2119:2177	a cost-effective and durable antibacterial treatment option	2119:2177	This scaffold can provide a cost-effective and durable antibacterial treatment option.
32764939	9	7	theme	only	1638:1641	arg1	gels					1643:1646	the alginate only gels	1625:1646	the alginate only gels	1625:1646	Bacterial resistance testing on Staphylococcus epidermidis indicated the addition of ZnO NPs to the gels decreased bacterial growth when compared to the alginate only gels.
32764939	3	8	theme	hydroxyl	516:523	arg1	radical					525:531	hydroxyl radical	516:531	hydroxyl radical generation	516:542	METHODS The antibacterial property of the ZnO NPs was confirmed by hydroxyl radical generation using ultraviolet (U.V.) photocatalysis.
32764939	1	9	theme	oxide	158:162	arg1	nanoparticles					170:182	zinc oxide (ZnO) nanoparticles	153:182	zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs	153:270	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	1	9	theme	oxide	158:162	arg1	NPs					185:187	NPs	185:187	NPs	185:187	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	6	10	theme	broth	1089:1093	arg1	testing					1095:1101	bacterial broth testing	1079:1101	bacterial broth testing	1079:1101	Envisioning an in-vivo application for the 3D printed ZnO NP-based alginates, we studied their antibacterial properties by bacterial broth testing, cytocompatibility via live/dead assay, and moisture retention capabilities utilizing a humidity sensor.
32764939	3	11	theme	U.V.	563:566	arg1	photocatalysis					569:582	ultraviolet (U.V.) photocatalysis	550:582	ultraviolet (U.V.) photocatalysis	550:582	METHODS The antibacterial property of the ZnO NPs was confirmed by hydroxyl radical generation using ultraviolet (U.V.) photocatalysis.
32764939	12	12	theme	ZnO	1961:1963	arg1	NPs					1965:1967	antibacterial ZnO NPs	1947:1967	antibacterial ZnO NPs	1947:1967	DISCUSSION The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing.
32764939	3	13	theme	ultraviolet	550:560	arg1	photocatalysis					569:582	ultraviolet (U.V.) photocatalysis	550:582	ultraviolet (U.V.) photocatalysis	550:582	METHODS The antibacterial property of the ZnO NPs was confirmed by hydroxyl radical generation using ultraviolet (U.V.) photocatalysis.
32764939	1	14	theme	nanoparticles	170:182	arg1	nanoparticles					170:182	zinc oxide (ZnO) nanoparticles	153:182	zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs	153:270	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	1	14	theme	nanoparticles	170:182	arg1	composite					140:148	a 3D printed composite	127:148	a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs	127:270	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	8	15	theme	TiO2	1391:1394	arg1	addition					1372:1379	the addition	1368:1379	the addition of ZnO or TiO2	1368:1394	For all samples, the addition of ZnO or TiO2 resulted in significantly stiffer gels in comparison with the alginate control.
32764939	4	16	theme	antibacterial	623:635	arg1	dioxide					594:600	Titanium dioxide	585:600	Titanium dioxide (TiO2)	585:607	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	4	16	theme	antibacterial	623:635	arg1	compound					637:644	a well-known antibacterial compound	610:644	a well-known antibacterial compound	610:644	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	12	17	dep	DISCUSSION	1883:1892	arg1	leads					1969:1973	leads	1969:1973	leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing	1969:2090	DISCUSSION The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing.
32764939	5	18	theme	printed	797:803	arg1	gels					805:808	3D printed gels	794:808	3D printed gels containing 0.5% and 1% w/v of ZnO	794:842	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	12	19	theme	printed	1918:1924	arg1	alginates					1926:1934	3D printed alginates	1915:1934	3D printed alginates containing antibacterial ZnO NPs	1915:1967	DISCUSSION The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing.
32764939	7	20	theme	casted	1335:1340	arg1	samples					1342:1348	manually casted samples	1326:1348	manually casted samples	1326:1348	RESULTS 3D printed constructs revealed significantly greater pore sizes and enhanced structural stability compared to manually casted samples.
32764939	5	21	theme	ZnO	840:842	arg1	ZnO					840:842	ZnO	840:842	ZnO	840:842	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	5	21	theme	ZnO	840:842	arg1	w/v					833:835	0.5% and 1% w/v	821:835	w/v	833:835	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	5	21	theme	ZnO	840:842	arg1	%					824:824	0.5% and 1% w/v	821:835	%	824:824	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	8	22	theme	stiffer	1422:1428	arg1	gels					1430:1433	significantly stiffer gels	1408:1433	significantly stiffer gels in comparison with the alginate control	1408:1473	For all samples, the addition of ZnO or TiO2 resulted in significantly stiffer gels in comparison with the alginate control.
32764939	9	23	from	testing	1497:1503	arg1	epidermidis					1523:1533	Staphylococcus epidermidis	1508:1533	Staphylococcus epidermidis	1508:1533	Bacterial resistance testing on Staphylococcus epidermidis indicated the addition of ZnO NPs to the gels decreased bacterial growth when compared to the alginate only gels.
32764939	12	24	theme	chronic	2070:2076	arg1	healing					2084:2090	chronic wound healing	2070:2090	chronic wound healing	2070:2090	DISCUSSION The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing.
32764939	10	25	theme	ZnO	1729:1731	arg1	NPs					1733:1735	ZnO NPs	1729:1735	ZnO NPs	1729:1735	Cell viability of STO-fibroblasts was not adversely affected by the addition of ZnO NPs to the alginate gels.
32764939	0	26	theme	Healing	61:67	arg1	Therapy					69:75	Wound Healing Therapy	55:75	Wound Healing Therapy	55:75	Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy.
32764939	12	27	contain	containing	1936:1945	arg2	NPs					1965:1967	antibacterial ZnO NPs	1947:1967	antibacterial ZnO NPs	1947:1967	DISCUSSION The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing.
32764939	12	27	contain	containing	1936:1945	arg1	alginates					1926:1934	3D printed alginates	1915:1934	3D printed alginates containing antibacterial ZnO NPs	1915:1967	DISCUSSION The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing.
32764939	4	28	dep	constructs	717:726	arg1	the					691:693	the	691:693	the	691:693	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	12	29	theme	exchange	2038:2045	arg1	mobility					2016:2023	accessible mobility	2005:2023	accessible mobility of molecular exchange required for improving chronic wound healing	2005:2090	DISCUSSION The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing.
32764939	8	30	theme	alginate	1458:1465	arg1	control					1467:1473	the alginate control	1454:1473	the alginate control	1454:1473	For all samples, the addition of ZnO or TiO2 resulted in significantly stiffer gels in comparison with the alginate control.
32764939	4	31	theme	alginate	708:715	arg1	constructs					717:726	ZnO NP-based alginate constructs	695:726	ZnO NP-based alginate constructs	695:726	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	7	32	theme	pore	1269:1272	arg1	sizes					1274:1278	significantly greater pore sizes	1247:1278	significantly greater pore sizes	1247:1278	RESULTS 3D printed constructs revealed significantly greater pore sizes and enhanced structural stability compared to manually casted samples.
32764939	7	33	theme	structural	1293:1302	arg1	stability					1304:1312	structural stability	1293:1312	structural stability	1293:1312	RESULTS 3D printed constructs revealed significantly greater pore sizes and enhanced structural stability compared to manually casted samples.
32764939	2	34	theme	infused	430:436	arg1	scaffolds					438:446	these ZnO NP infused scaffolds	417:446	these ZnO NP infused scaffolds	417:446	We primarily sought to confirm the mechanical properties and cell compatibility of these ZnO NP infused scaffolds.
32764939	11	35	theme	increased	1845:1853	arg1	retention					1864:1872	increased humidity retention	1845:1872	increased humidity retention in gels	1845:1880	Furthermore, the addition of increasing doses of ZnO NPs to the alginate demonstrated increased humidity retention in gels.
32764939	0	36	theme	Alginate	0:7	arg1	Hydrogels					9:17	Alginate Hydrogels	0:17	Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy.	0:76	Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy.
32764939	1	37	theme	alginate	251:258	arg1	constructs					261:270	hydrogel (alginate) constructs	241:270	hydrogel (alginate) constructs	241:270	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	2	38	theme	ZnO	423:425	arg1	scaffolds					438:446	these ZnO NP infused scaffolds	417:446	these ZnO NP infused scaffolds	417:446	We primarily sought to confirm the mechanical properties and cell compatibility of these ZnO NP infused scaffolds.
32764939	4	39	theme	ZnO	695:697	arg1	constructs					717:726	ZnO NP-based alginate constructs	695:726	ZnO NP-based alginate constructs	695:726	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	10	40	theme	Cell	1649:1652	arg1	viability					1654:1662	Cell viability	1649:1662	Cell viability of STO-fibroblasts	1649:1681	Cell viability of STO-fibroblasts was not adversely affected by the addition of ZnO NPs to the alginate gels.
32764939	5	41	theme	ZnO	783:785	arg1	group					787:791	the ZnO group	779:791	the ZnO group	779:791	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	9	42	theme	ZnO	1561:1563	arg1	NPs					1565:1567	ZnO NPs	1561:1567	ZnO NPs	1561:1567	Bacterial resistance testing on Staphylococcus epidermidis indicated the addition of ZnO NPs to the gels decreased bacterial growth when compared to the alginate only gels.
32764939	6	43	theme	in-vivo	971:977	arg1	application					979:989	an in-vivo application	968:989	an in-vivo application for the 3D printed ZnO NP-based alginates	968:1031	Envisioning an in-vivo application for the 3D printed ZnO NP-based alginates, we studied their antibacterial properties by bacterial broth testing, cytocompatibility via live/dead assay, and moisture retention capabilities utilizing a humidity sensor.
32764939	2	44	theme	cell	395:398	arg1	compatibility					400:412	cell compatibility	395:412	cell compatibility	395:412	We primarily sought to confirm the mechanical properties and cell compatibility of these ZnO NP infused scaffolds.
32764939	0	45	theme	ZnO	33:35	arg1	Nanoparticles					37:49	Embedded ZnO Nanoparticles	24:49	Embedded ZnO Nanoparticles	24:49	Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy.
32764939	1	46	with	nanoparticles	170:182	arg1	activities					210:219	photocatalytic activities	195:219	photocatalytic activities encapsulated within hydrogel (alginate) constructs	195:270	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	5	47	theme	rheological	934:944	arg1	analysis					946:953	rheological analysis	934:953	rheological analysis	934:953	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	11	48	theme	ZnO	1808:1810	arg1	NPs					1812:1814	ZnO NPs	1808:1814	ZnO NPs	1808:1814	Furthermore, the addition of increasing doses of ZnO NPs to the alginate demonstrated increased humidity retention in gels.
32764939	4	49	theme	antibacterial	738:750	arg1	efficacies					752:761	their antibacterial efficacies	732:761	their antibacterial efficacies	732:761	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	3	50	theme	antibacterial	461:473	arg1	property					475:482	The antibacterial property	457:482	METHODS The antibacterial property of the ZnO NPs	449:497	METHODS The antibacterial property of the ZnO NPs was confirmed by hydroxyl radical generation using ultraviolet (U.V.) photocatalysis.
32764939	13	51	theme	treatment	2162:2170	arg1	option					2172:2177	a cost-effective and durable antibacterial treatment option	2119:2177	a cost-effective and durable antibacterial treatment option	2119:2177	This scaffold can provide a cost-effective and durable antibacterial treatment option.
32764939	5	52	theme	swelling	909:916	arg1	evaluation					918:927	swelling evaluation	909:927	swelling evaluation	909:927	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	7	53	theme	3D	1216:1217	arg1	constructs					1227:1236	3D printed constructs	1216:1236	3D printed constructs	1216:1236	RESULTS 3D printed constructs revealed significantly greater pore sizes and enhanced structural stability compared to manually casted samples.
32764939	8	54	with	comparison	1438:1447	arg1	control					1467:1473	the alginate control	1454:1473	the alginate control	1454:1473	For all samples, the addition of ZnO or TiO2 resulted in significantly stiffer gels in comparison with the alginate control.
32764939	1	55	theme	photocatalytic	195:208	arg1	activities					210:219	photocatalytic activities	195:219	photocatalytic activities encapsulated within hydrogel (alginate) constructs	195:270	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	3	56	theme	ZnO	491:493	arg1	NPs					495:497	the ZnO NPs	487:497	the ZnO NPs	487:497	METHODS The antibacterial property of the ZnO NPs was confirmed by hydroxyl radical generation using ultraviolet (U.V.) photocatalysis.
32764939	13	57	theme	cost-effective	2121:2134	arg1	option					2172:2177	a cost-effective and durable antibacterial treatment option	2119:2177	a cost-effective and durable antibacterial treatment option	2119:2177	This scaffold can provide a cost-effective and durable antibacterial treatment option.
32764939	6	58	theme	ZnO	1010:1012	arg1	alginates					1023:1031	the 3D printed ZnO NP-based alginates	995:1031	the 3D printed ZnO NP-based alginates	995:1031	Envisioning an in-vivo application for the 3D printed ZnO NP-based alginates, we studied their antibacterial properties by bacterial broth testing, cytocompatibility via live/dead assay, and moisture retention capabilities utilizing a humidity sensor.
32764939	3	59	theme	radical	525:531	arg1	generation					533:542	hydroxyl radical generation	516:542	hydroxyl radical generation	516:542	METHODS The antibacterial property of the ZnO NPs was confirmed by hydroxyl radical generation using ultraviolet (U.V.) photocatalysis.
32764939	1	60	theme	hydrogel	241:248	arg1	constructs					261:270	hydrogel (alginate) constructs	241:270	hydrogel (alginate) constructs	241:270	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	9	61	theme	alginate	1629:1636	arg1	gels					1643:1646	the alginate only gels	1625:1646	the alginate only gels	1625:1646	Bacterial resistance testing on Staphylococcus epidermidis indicated the addition of ZnO NPs to the gels decreased bacterial growth when compared to the alginate only gels.
32764939	9	62	theme	resistance	1486:1495	arg1	testing					1497:1503	Bacterial resistance testing	1476:1503	Bacterial resistance testing on Staphylococcus epidermidis	1476:1533	Bacterial resistance testing on Staphylococcus epidermidis indicated the addition of ZnO NPs to the gels decreased bacterial growth when compared to the alginate only gels.
32764939	6	63	theme	antibacterial	1051:1063	arg1	properties					1065:1074	their antibacterial properties	1045:1074	their antibacterial properties	1045:1074	Envisioning an in-vivo application for the 3D printed ZnO NP-based alginates, we studied their antibacterial properties by bacterial broth testing, cytocompatibility via live/dead assay, and moisture retention capabilities utilizing a humidity sensor.
32764939	1	64	theme	zinc	153:156	arg1	ZnO					165:167	ZnO	165:167	ZnO	165:167	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	1	64	theme	zinc	153:156	arg1	oxide					158:162	zinc oxide	153:162	zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs	153:270	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	6	65	theme	humidity	1191:1198	arg1	sensor					1200:1205	a humidity sensor	1189:1205	a humidity sensor	1189:1205	Envisioning an in-vivo application for the 3D printed ZnO NP-based alginates, we studied their antibacterial properties by bacterial broth testing, cytocompatibility via live/dead assay, and moisture retention capabilities utilizing a humidity sensor.
32764939	10	66	theme	alginate	1744:1751	arg1	gels					1753:1756	the alginate gels	1740:1756	the alginate gels	1740:1756	Cell viability of STO-fibroblasts was not adversely affected by the addition of ZnO NPs to the alginate gels.
32764939	12	67	theme	alginates	1926:1934	arg1	customization					1898:1910	The customization	1894:1910	The customization of 3D printed alginates containing antibacterial ZnO NPs	1894:1967	DISCUSSION The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing.
32764939	6	68	theme	bacterial	1079:1087	arg1	testing					1095:1101	bacterial broth testing	1079:1101	bacterial broth testing	1079:1101	Envisioning an in-vivo application for the 3D printed ZnO NP-based alginates, we studied their antibacterial properties by bacterial broth testing, cytocompatibility via live/dead assay, and moisture retention capabilities utilizing a humidity sensor.
32764939	5	69	theme	casted	885:890	arg1	samples					892:898	manually casted samples	876:898	manually casted samples	876:898	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	12	70	theme	antibacterial	1947:1959	arg1	NPs					1965:1967	antibacterial ZnO NPs	1947:1967	antibacterial ZnO NPs	1947:1967	DISCUSSION The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing.
32764939	12	71	theme	molecular	2028:2036	arg1	exchange					2038:2045	molecular exchange	2028:2045	molecular exchange	2028:2045	DISCUSSION The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing.
32764939	12	72	theme	wound	2078:2082	arg1	healing					2084:2090	chronic wound healing	2070:2090	chronic wound healing	2070:2090	DISCUSSION The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing.
32764939	11	73	theme	NPs	1812:1814	arg1	doses					1799:1803	increasing doses	1788:1803	increasing doses of ZnO NPs	1788:1814	Furthermore, the addition of increasing doses of ZnO NPs to the alginate demonstrated increased humidity retention in gels.
32764939	5	74	theme	3D	794:795	arg1	gels					805:808	3D printed gels	794:808	3D printed gels containing 0.5% and 1% w/v of ZnO	794:842	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	4	75	theme	well-known	612:621	arg1	dioxide					594:600	Titanium dioxide	585:600	Titanium dioxide (TiO2)	585:607	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	4	75	theme	well-known	612:621	arg1	compound					637:644	a well-known antibacterial compound	610:644	a well-known antibacterial compound	610:644	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	11	76	theme	increasing	1788:1797	arg1	doses					1799:1803	increasing doses	1788:1803	increasing doses of ZnO NPs	1788:1814	Furthermore, the addition of increasing doses of ZnO NPs to the alginate demonstrated increased humidity retention in gels.
32764939	4	77	used	used	651:654	arg2	TiO2					603:606	TiO2	603:606	TiO2	603:606	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	4	77	used	used	651:654	arg2	control					670:676	a positive control	659:676	a positive control (1% w/v)	659:685	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	4	77	used	used	651:654	arg2	dioxide					594:600	Titanium dioxide	585:600	Titanium dioxide (TiO2)	585:607	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	4	77	used	used	651:654	arg2	compound					637:644	a well-known antibacterial compound	610:644	a well-known antibacterial compound	610:644	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	12	78	theme	3D	1915:1916	arg1	alginates					1926:1934	3D printed alginates	1915:1934	3D printed alginates containing antibacterial ZnO NPs	1915:1967	DISCUSSION The customization of 3D printed alginates containing antibacterial ZnO NPs leads to an alternative that allows accessible mobility of molecular exchange required for improving chronic wound healing.
32764939	6	79	theme	moisture	1147:1154	arg1	capabilities					1166:1177	moisture retention capabilities	1147:1177	moisture retention capabilities utilizing a humidity sensor	1147:1205	Envisioning an in-vivo application for the 3D printed ZnO NP-based alginates, we studied their antibacterial properties by bacterial broth testing, cytocompatibility via live/dead assay, and moisture retention capabilities utilizing a humidity sensor.
32764939	1	80	dep	INTRODUCTION	78:89	arg1	designed					118:125	designed	118:125	designed	118:125	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	7	81	theme	manually	1326:1333	arg1	samples					1342:1348	manually casted samples	1326:1348	manually casted samples	1326:1348	RESULTS 3D printed constructs revealed significantly greater pore sizes and enhanced structural stability compared to manually casted samples.
32764939	4	82	theme	%	680:680	arg1	control					670:676	a positive control	659:676	a positive control (1% w/v)	659:685	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	4	82	theme	%	680:680	arg1	w/v					682:684	1% w/v	679:684	1% w/v	679:684	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	11	83	theme	doses	1799:1803	arg1	addition					1776:1783	the addition	1772:1783	the addition of increasing doses of ZnO NPs to the alginate	1772:1830	Furthermore, the addition of increasing doses of ZnO NPs to the alginate demonstrated increased humidity retention in gels.
32764939	1	84	theme	3D	129:130	arg1	nanoparticles					170:182	zinc oxide (ZnO) nanoparticles	153:182	zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs	153:270	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	1	84	theme	3D	129:130	arg1	composite					140:148	a 3D printed composite	127:148	a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs	127:270	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	6	85	theme	live/dead	1126:1134	arg1	assay					1136:1140	live/dead assay	1126:1140	live/dead assay	1126:1140	Envisioning an in-vivo application for the 3D printed ZnO NP-based alginates, we studied their antibacterial properties by bacterial broth testing, cytocompatibility via live/dead assay, and moisture retention capabilities utilizing a humidity sensor.
32764939	11	86	from	retention	1864:1872	arg1	gels					1877:1880	gels	1877:1880	gels	1877:1880	Furthermore, the addition of increasing doses of ZnO NPs to the alginate demonstrated increased humidity retention in gels.
32764939	1	87	theme	wound	319:323	arg1	healing					325:331	wound healing	319:331	wound healing	319:331	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	5	88	theme	%	831:831	arg1	w/v					833:835	0.5% and 1% w/v	821:835	w/v	833:835	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	4	89	theme	positive	661:668	arg1	control					670:676	a positive control	659:676	a positive control (1% w/v)	659:685	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	4	89	theme	positive	661:668	arg1	dioxide					594:600	Titanium dioxide	585:600	Titanium dioxide (TiO2)	585:607	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	4	89	theme	positive	661:668	arg1	w/v					682:684	1% w/v	679:684	1% w/v	679:684	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	9	90	theme	bacterial	1591:1599	arg1	growth					1601:1606	bacterial growth	1591:1606	bacterial growth	1591:1606	Bacterial resistance testing on Staphylococcus epidermidis indicated the addition of ZnO NPs to the gels decreased bacterial growth when compared to the alginate only gels.
32764939	7	91	dep	RESULTS	1208:1214	arg1	revealed					1238:1245	revealed	1238:1245	revealed significantly greater pore sizes	1238:1278	RESULTS 3D printed constructs revealed significantly greater pore sizes and enhanced structural stability compared to manually casted samples.
32764939	7	91	dep	RESULTS	1208:1214	arg1	enhanced					1284:1291	enhanced	1284:1291	enhanced structural stability compared to manually casted samples	1284:1348	RESULTS 3D printed constructs revealed significantly greater pore sizes and enhanced structural stability compared to manually casted samples.
32764939	10	92	theme	NPs	1733:1735	arg1	addition					1717:1724	the addition	1713:1724	the addition of ZnO NPs to the alginate gels	1713:1756	Cell viability of STO-fibroblasts was not adversely affected by the addition of ZnO NPs to the alginate gels.
32764939	5	93	contain	containing	810:819	arg2	%					824:824	0.5% and 1% w/v	821:835	%	824:824	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	5	93	contain	containing	810:819	arg2	ZnO					840:842	ZnO	840:842	ZnO	840:842	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	5	93	contain	containing	810:819	arg2	w/v					833:835	0.5% and 1% w/v	821:835	w/v	833:835	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	5	93	contain	containing	810:819	arg1	gels					805:808	3D printed gels	794:808	3D printed gels containing 0.5% and 1% w/v of ZnO	794:842	Among the ZnO group, 3D printed gels containing 0.5% and 1% w/v of ZnO were analyzed and compared with manually casted samples via SEM, swelling evaluation, and rheological analysis.
32764939	4	94	theme	NP-based	699:706	arg1	constructs					717:726	ZnO NP-based alginate constructs	695:726	ZnO NP-based alginate constructs	695:726	Titanium dioxide (TiO2), a well-known antibacterial compound, was used as a positive control (1% w/v) for the ZnO NP-based alginate constructs and their antibacterial efficacies compared.
32764939	8	95	from	gels	1430:1433	arg1	comparison					1438:1447	comparison	1438:1447	comparison with the alginate control	1438:1473	For all samples, the addition of ZnO or TiO2 resulted in significantly stiffer gels in comparison with the alginate control.
32764939	6	96	theme	printed	1002:1008	arg1	alginates					1023:1031	the 3D printed ZnO NP-based alginates	995:1031	the 3D printed ZnO NP-based alginates	995:1031	Envisioning an in-vivo application for the 3D printed ZnO NP-based alginates, we studied their antibacterial properties by bacterial broth testing, cytocompatibility via live/dead assay, and moisture retention capabilities utilizing a humidity sensor.
32764939	2	97	theme	mechanical	369:378	arg1	properties					380:389	the mechanical properties	365:389	the mechanical properties	365:389	We primarily sought to confirm the mechanical properties and cell compatibility of these ZnO NP infused scaffolds.
32764939	2	98	theme	NP	427:428	arg1	scaffolds					438:446	these ZnO NP infused scaffolds	417:446	these ZnO NP infused scaffolds	417:446	We primarily sought to confirm the mechanical properties and cell compatibility of these ZnO NP infused scaffolds.
32764939	11	99	theme	humidity	1855:1862	arg1	retention					1864:1872	increased humidity retention	1845:1872	increased humidity retention in gels	1845:1880	Furthermore, the addition of increasing doses of ZnO NPs to the alginate demonstrated increased humidity retention in gels.
32764939	0	100	theme	Embedded	24:31	arg1	Nanoparticles					37:49	Embedded ZnO Nanoparticles	24:49	Embedded ZnO Nanoparticles	24:49	Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy.
32764939	1	101	theme	in-vitro	99:106	arg1	study					108:112	this in-vitro study	94:112	this in-vitro study	94:112	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	7	102	theme	greater	1261:1267	arg1	sizes					1274:1278	significantly greater pore sizes	1247:1278	significantly greater pore sizes	1247:1278	RESULTS 3D printed constructs revealed significantly greater pore sizes and enhanced structural stability compared to manually casted samples.
32764939	9	103	dep	decreased	1581:1589	arg1	indicated					1535:1543	indicated	1535:1543	indicated	1535:1543	Bacterial resistance testing on Staphylococcus epidermidis indicated the addition of ZnO NPs to the gels decreased bacterial growth when compared to the alginate only gels.
32764939	9	104	theme	NPs	1565:1567	arg1	addition					1549:1556	the addition	1545:1556	the addition of ZnO NPs to the gels	1545:1579	Bacterial resistance testing on Staphylococcus epidermidis indicated the addition of ZnO NPs to the gels decreased bacterial growth when compared to the alginate only gels.
32764939	0	105	theme	Wound	55:59	arg1	Therapy					69:75	Wound Healing Therapy	55:75	Wound Healing Therapy	55:75	Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy.
32764939	1	106	theme	antibacterial	277:289	arg1	purposes					291:298	antibacterial purposes	277:298	antibacterial purposes applicable towards wound healing	277:331	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	7	107	theme	printed	1219:1225	arg1	constructs					1227:1236	3D printed constructs	1216:1236	3D printed constructs	1216:1236	RESULTS 3D printed constructs revealed significantly greater pore sizes and enhanced structural stability compared to manually casted samples.
32764939	2	108	theme	scaffolds	438:446	arg1	properties					380:389	the mechanical properties	365:389	the mechanical properties	365:389	We primarily sought to confirm the mechanical properties and cell compatibility of these ZnO NP infused scaffolds.
32764939	2	108	theme	scaffolds	438:446	arg1	compatibility					400:412	cell compatibility	395:412	cell compatibility	395:412	We primarily sought to confirm the mechanical properties and cell compatibility of these ZnO NP infused scaffolds.
32764939	1	109	theme	printed	132:138	arg1	nanoparticles					170:182	zinc oxide (ZnO) nanoparticles	153:182	zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs	153:270	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	1	109	theme	printed	132:138	arg1	composite					140:148	a 3D printed composite	127:148	a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs	127:270	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	0	110	with	Hydrogels	9:17	arg1	Nanoparticles					37:49	Embedded ZnO Nanoparticles	24:49	Embedded ZnO Nanoparticles	24:49	Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy.
32764939	10	111	theme	STO-fibroblasts	1667:1681	arg1	viability					1654:1662	Cell viability	1649:1662	Cell viability of STO-fibroblasts	1649:1681	Cell viability of STO-fibroblasts was not adversely affected by the addition of ZnO NPs to the alginate gels.
32764939	1	112	theme	applicable	300:309	arg1	purposes					291:298	antibacterial purposes	277:298	antibacterial purposes applicable towards wound healing	277:331	INTRODUCTION In this in-vitro study, we designed a 3D printed composite of zinc oxide (ZnO) nanoparticles (NPs) with photocatalytic activities encapsulated within hydrogel (alginate) constructs, for antibacterial purposes applicable towards wound healing.
32764939	3	113	dep	METHODS	449:455	arg1	property					475:482	The antibacterial property	457:482	METHODS The antibacterial property of the ZnO NPs	449:497	METHODS The antibacterial property of the ZnO NPs was confirmed by hydroxyl radical generation using ultraviolet (U.V.) photocatalysis.
32764939	13	114	theme	durable	2140:2146	arg1	option					2172:2177	a cost-effective and durable antibacterial treatment option	2119:2177	a cost-effective and durable antibacterial treatment option	2119:2177	This scaffold can provide a cost-effective and durable antibacterial treatment option.
32764939	6	115	theme	3D	999:1000	arg1	alginates					1023:1031	the 3D printed ZnO NP-based alginates	995:1031	the 3D printed ZnO NP-based alginates	995:1031	Envisioning an in-vivo application for the 3D printed ZnO NP-based alginates, we studied their antibacterial properties by bacterial broth testing, cytocompatibility via live/dead assay, and moisture retention capabilities utilizing a humidity sensor.
32764939	8	116	theme	ZnO	1384:1386	arg1	addition					1372:1379	the addition	1368:1379	the addition of ZnO or TiO2	1368:1394	For all samples, the addition of ZnO or TiO2 resulted in significantly stiffer gels in comparison with the alginate control.
32798545	5	0	theme	63.9 kJ/mol	1118:1128	arg1	energy					1108:1113	their kinetic activation energy	1083:1113	their kinetic activation energy of 63.9 kJ/mol	1083:1128	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32798545	3	1	theme	high	648:651	arg1	modulus					662:668	a high specific modulus	646:668	a high specific modulus (1.18-2.04 MPa∙ m3/kg)	646:691	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	3	1	theme	high	648:651	arg1	m3/kg					686:690	1.18-2.04 MPa∙ m3/kg	671:690	1.18-2.04 MPa∙ m3/kg	671:690	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	2	2	theme	chemical	330:337	arg1	properties					367:376	The physical, chemical, thermal, and morphological properties	316:376	The physical, chemical, thermal, and morphological properties	316:376	The physical, chemical, thermal, and morphological properties of the LV fibers, together with their microstructure are investigated.
32798545	5	3	theme	thermoplastic	1178:1190	arg1	composites					1198:1207	thermoplastic green composites	1178:1207	thermoplastic green composites with a working temperature below 300°	1178:1245	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32798545	3	4	theme	specific	653:660	arg1	modulus					662:668	a high specific modulus	646:668	a high specific modulus (1.18-2.04 MPa∙ m3/kg)	646:691	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	3	4	theme	specific	653:660	arg1	m3/kg					686:690	1.18-2.04 MPa∙ m3/kg	671:690	1.18-2.04 MPa∙ m3/kg	671:690	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	5	5	theme	green	1192:1196	arg1	composites					1198:1207	thermoplastic green composites	1178:1207	thermoplastic green composites with a working temperature below 300°	1178:1245	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32798545	1	6	theme	cellulose	221:229	arg1	material					249:256	cellulose fiber reinforcing material	221:256	cellulose fiber reinforcing material	221:256	The purpose of this study is to investigate the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials.
32798545	0	7	theme	physicochemical	74:88	arg1	properties					105:114	physicochemical and structural properties	74:114	physicochemical and structural properties	74:114	Characterization of potential cellulose fiber from Luffa vine: A study on physicochemical and structural properties.
32798545	0	8	from	vine	57:60	arg1	Characterization					0:15	Characterization	0:15	Characterization of potential cellulose fiber from Luffa vine: A study on physicochemical and structural properties.	0:115	Characterization of potential cellulose fiber from Luffa vine: A study on physicochemical and structural properties.
32798545	4	9	contain	contains	914:921	arg2	saponins					923:930	saponins	923:930	saponins	923:930	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	9	contain	contains	914:921	arg1	it					911:912	it	911:912	it	911:912	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	1	10	theme	fiber	231:235	arg1	material					249:256	cellulose fiber reinforcing material	221:256	cellulose fiber reinforcing material	221:256	The purpose of this study is to investigate the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials.
32798545	3	11	theme	microscopic	496:506	arg1	characteristics					508:522	microscopic characteristics	496:522	microscopic characteristics	496:522	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	2	12	theme	morphological	353:365	arg1	properties					367:376	The physical, chemical, thermal, and morphological properties	316:376	The physical, chemical, thermal, and morphological properties	316:376	The physical, chemical, thermal, and morphological properties of the LV fibers, together with their microstructure are investigated.
32798545	0	13	theme	structural	94:103	arg1	properties					105:114	physicochemical and structural properties	74:114	physicochemical and structural properties	74:114	Characterization of potential cellulose fiber from Luffa vine: A study on physicochemical and structural properties.
32798545	2	14	theme	LV	385:386	arg1	fibers					388:393	the LV fibers	381:393	the LV fibers	381:393	The physical, chemical, thermal, and morphological properties of the LV fibers, together with their microstructure are investigated.
32798545	4	15	theme	lignin	815:820	arg1	content					822:828	a high lignin content	808:828	a high lignin content (25.18%)	808:837	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	15	theme	lignin	815:820	arg1	%					836:836	25.18%	831:836	25.18%	831:836	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	5	16	theme	kinetic	1089:1095	arg1	energy					1108:1113	their kinetic activation energy	1083:1113	their kinetic activation energy of 63.9 kJ/mol	1083:1128	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32798545	4	17	theme	chemical	698:705	arg1	diffraction					714:724	The chemical, X-ray diffraction	694:724	diffraction	714:724	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	1	18	theme	natural	165:171	arg1	fiber					189:193	the natural Luffa vine (LV) fiber	161:193	the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials	161:313	The purpose of this study is to investigate the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials.
32798545	1	19	theme	reinforcing	237:247	arg1	material					249:256	cellulose fiber reinforcing material	221:256	cellulose fiber reinforcing material	221:256	The purpose of this study is to investigate the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials.
32798545	4	20	theme	high	810:813	arg1	content					822:828	a high lignin content	808:828	a high lignin content (25.18%)	808:837	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	20	theme	high	810:813	arg1	%					836:836	25.18%	831:836	25.18%	831:836	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	1	21	theme	Luffa	173:177	arg1	fiber					189:193	the natural Luffa vine (LV) fiber	161:193	the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials	161:313	The purpose of this study is to investigate the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials.
32798545	0	22	theme	cellulose	30:38	arg1	fiber					40:44	potential cellulose fiber	20:44	potential cellulose fiber	20:44	Characterization of potential cellulose fiber from Luffa vine: A study on physicochemical and structural properties.
32798545	5	23	theme	activation	1097:1106	arg1	energy					1108:1113	their kinetic activation energy	1083:1113	their kinetic activation energy of 63.9 kJ/mol	1083:1128	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32798545	4	24	theme	relative	861:868	arg1	crystallinity					870:882	a relatively high relative crystallinity	843:882	a relatively high relative crystallinity (37.18%) of cellulose	843:904	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	24	theme	relative	861:868	arg1	%					890:890	37.18%	885:890	37.18%	885:890	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	3	25	theme	mechanical	529:538	arg1	properties					540:549	mechanical properties	529:549	mechanical properties	529:549	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	3	26	with	fiber	612:616	arg1	modulus					662:668	a high specific modulus	646:668	a high specific modulus (1.18-2.04 MPa∙ m3/kg)	646:691	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	3	26	with	fiber	612:616	arg1	structure					632:640	a porous structure	623:640	a porous structure	623:640	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	3	26	with	fiber	612:616	arg1	m3/kg					686:690	1.18-2.04 MPa∙ m3/kg	671:690	1.18-2.04 MPa∙ m3/kg	671:690	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	1	27	theme	vine	179:182	arg1	fiber					189:193	the natural Luffa vine (LV) fiber	161:193	the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials	161:313	The purpose of this study is to investigate the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials.
32798545	0	28	theme	potential	20:28	arg1	fiber					40:44	potential cellulose fiber	20:44	potential cellulose fiber	20:44	Characterization of potential cellulose fiber from Luffa vine: A study on physicochemical and structural properties.
32798545	4	29	theme	high	856:859	arg1	crystallinity					870:882	a relatively high relative crystallinity	843:882	a relatively high relative crystallinity (37.18%) of cellulose	843:904	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	29	theme	high	856:859	arg1	%					890:890	37.18%	885:890	37.18%	885:890	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	5	30	theme	thermogravimetric	989:1005	arg1	analysis					1007:1014	The thermogravimetric analysis	985:1014	The thermogravimetric analysis	985:1014	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32798545	3	31	theme	LV	484:485	arg1	density					487:493	the LV density	480:493	the LV density	480:493	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	2	32	theme	fibers	388:393	arg1	properties					367:376	The physical, chemical, thermal, and morphological properties	316:376	The physical, chemical, thermal, and morphological properties	316:376	The physical, chemical, thermal, and morphological properties of the LV fibers, together with their microstructure are investigated.
32798545	1	33	theme	lightweight	262:272	arg1	materials					305:313	lightweight and decay-resistance composite materials	262:313	lightweight and decay-resistance composite materials	262:313	The purpose of this study is to investigate the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials.
32798545	0	34	from	study	65:69	arg1	properties					105:114	physicochemical and structural properties	74:114	physicochemical and structural properties	74:114	Characterization of potential cellulose fiber from Luffa vine: A study on physicochemical and structural properties.
32798545	1	35	theme	LV	185:186	arg1	fiber					189:193	the natural Luffa vine (LV) fiber	161:193	the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials	161:313	The purpose of this study is to investigate the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials.
32798545	0	36	theme	fiber	40:44	arg1	Characterization					0:15	Characterization	0:15	Characterization of potential cellulose fiber from Luffa vine: A study on physicochemical and structural properties.	0:115	Characterization of potential cellulose fiber from Luffa vine: A study on physicochemical and structural properties.
32798545	5	37	from	materials	1165:1173	arg1	composites					1198:1207	thermoplastic green composites	1178:1207	thermoplastic green composites with a working temperature below 300°	1178:1245	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32798545	3	38	theme	natural	604:610	arg1	fiber					612:616	a lightweight (200-550 kg/m3) natural fiber	574:616	a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg)	574:691	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	3	38	theme	natural	604:610	arg1	crop					566:569	this crop	561:569	this crop	561:569	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	1	39	theme	decay-resistance	278:293	arg1	materials					305:313	lightweight and decay-resistance composite materials	262:313	lightweight and decay-resistance composite materials	262:313	The purpose of this study is to investigate the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials.
32798545	5	40	dep	Moreover	1066:1073	arg1	up					1050:1051	up	1050:1051	up	1050:1051	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32798545	5	41	used	used	1143:1146	arg2	materials					1165:1173	reinforcement materials	1151:1173	reinforcement materials in thermoplastic green composites with a working temperature below 300°	1151:1245	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32798545	5	41	used	used	1143:1146	arg2	they					1131:1134	they	1131:1134	they	1131:1134	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32798545	0	42	theme	Luffa	51:55	arg1	vine					57:60	Luffa vine	51:60	Luffa vine	51:60	Characterization of potential cellulose fiber from Luffa vine: A study on physicochemical and structural properties.
32798545	1	43	theme	composite	295:303	arg1	materials					305:313	lightweight and decay-resistance composite materials	262:313	lightweight and decay-resistance composite materials	262:313	The purpose of this study is to investigate the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials.
32798545	2	44	theme	physical	320:327	arg1	properties					367:376	The physical, chemical, thermal, and morphological properties	316:376	The physical, chemical, thermal, and morphological properties	316:376	The physical, chemical, thermal, and morphological properties of the LV fibers, together with their microstructure are investigated.
32798545	4	45	theme	spectroscopy	761:772	arg1	analyses					774:781	infrared spectroscopy analyses	752:781	infrared spectroscopy analyses	752:781	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	46	dep	diffraction	714:724	arg1	X-ray					708:712	The chemical, X-ray diffraction	694:724	X-ray	708:712	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	47	theme	erosion	952:958	arg1	resistance					960:969	its erosion resistance	948:969	its erosion resistance	948:969	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	3	48	theme	200-550 kg/m3	589:601	arg1	fiber					612:616	a lightweight (200-550 kg/m3) natural fiber	574:616	a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg)	574:691	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	3	48	theme	200-550 kg/m3	589:601	arg1	crop					566:569	this crop	561:569	this crop	561:569	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	3	49	theme	test	453:456	arg1	results					458:464	The test results	449:464	The test results	449:464	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	3	50	theme	porous	625:630	arg1	structure					632:640	a porous structure	623:640	a porous structure	623:640	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	2	51	theme	thermal	340:346	arg1	properties					367:376	The physical, chemical, thermal, and morphological properties	316:376	The physical, chemical, thermal, and morphological properties	316:376	The physical, chemical, thermal, and morphological properties of the LV fibers, together with their microstructure are investigated.
32798545	4	52	contain	has	804:806	arg2	%					836:836	25.18%	831:836	25.18%	831:836	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	52	contain	has	804:806	arg2	crystallinity					870:882	a relatively high relative crystallinity	843:882	a relatively high relative crystallinity (37.18%) of cellulose	843:904	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	52	contain	has	804:806	arg2	content					822:828	a high lignin content	808:828	a high lignin content (25.18%)	808:837	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	52	contain	has	804:806	arg2	%					890:890	37.18%	885:890	37.18%	885:890	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	52	contain	has	804:806	arg1	LV					801:802	the LV	797:802	the LV	797:802	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	53	theme	infrared	752:759	arg1	analyses					774:781	infrared spectroscopy analyses	752:781	infrared spectroscopy analyses	752:781	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	3	54	theme	lightweight	576:586	arg1	fiber					612:616	a lightweight (200-550 kg/m3) natural fiber	574:616	a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg)	574:691	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	3	54	theme	lightweight	576:586	arg1	crop					566:569	this crop	561:569	this crop	561:569	The test results conclude that the LV density, microscopic characteristics, and mechanical properties show that this crop is a lightweight (200-550 kg/m3) natural fiber with a porous structure and a high specific modulus (1.18-2.04 MPa∙ m3/kg).
32798545	4	55	dep	Fourier	734:740	arg1	transform					742:750	transform	742:750	transform infrared spectroscopy analyses	742:781	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	5	56	theme	working	1216:1222	arg1	temperature					1224:1234	a working temperature	1214:1234	a working temperature below 300°	1214:1245	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32798545	5	57	with	composites	1198:1207	arg1	temperature					1224:1234	a working temperature	1214:1234	a working temperature below 300°	1214:1245	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32798545	4	58	theme	cellulose	896:904	arg1	crystallinity					870:882	a relatively high relative crystallinity	843:882	a relatively high relative crystallinity (37.18%) of cellulose	843:904	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	58	theme	cellulose	896:904	arg1	%					890:890	37.18%	885:890	37.18%	885:890	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	58	theme	cellulose	896:904	arg1	content					822:828	a high lignin content	808:828	a high lignin content (25.18%)	808:837	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	4	58	theme	cellulose	896:904	arg1	%					836:836	25.18%	831:836	25.18%	831:836	The chemical, X-ray diffraction and the Fourier transform infrared spectroscopy analyses indicate that the LV has a high lignin content (25.18%) and a relatively high relative crystallinity (37.18%) of cellulose, and it contains saponins, which increase its erosion resistance and hardness.
32798545	0	59	dep	Characterization	0:15	arg1	study					65:69	A study	63:69	Characterization of potential cellulose fiber from Luffa vine: A study on physicochemical and structural properties.	0:115	Characterization of potential cellulose fiber from Luffa vine: A study on physicochemical and structural properties.
32798545	1	60	theme	study	137:141	arg1	purpose					121:127	The purpose	117:127	The purpose of this study	117:141	The purpose of this study is to investigate the natural Luffa vine (LV) fiber to be effectively used as cellulose fiber reinforcing material for lightweight and decay-resistance composite materials.
32798545	5	61	theme	reinforcement	1151:1163	arg1	they					1131:1134	they	1131:1134	they	1131:1134	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32798545	5	61	theme	reinforcement	1151:1163	arg1	materials					1165:1173	reinforcement materials	1151:1173	reinforcement materials in thermoplastic green composites with a working temperature below 300°	1151:1245	The thermogravimetric analysis reveals that the fibers can stand up to 315.4 °C. Moreover, due to their kinetic activation energy of 63.9 kJ/mol, they can be used as reinforcement materials in thermoplastic green composites with a working temperature below 300°.
32790232	5	0	theme	network	713:719	arg1	components					656:665	the components	652:665	Physicochemical interactions between the components of the intertwined gelatin-cellulose-alginate network	615:719	Physicochemical interactions between the components of the intertwined gelatin-cellulose-alginate network are studied via altering copolymer ratios.
32790232	6	1	theme	materials	785:793	arg1	structure					768:776	The structure	764:776	The structure of the materials and porosity	764:806	The structure of the materials and porosity are assessed using infrared spectroscopy, swelling, and degradation experiments.
32790232	1	2	theme	intricate	165:173	arg1	scaffolds					190:198	intricate and customized scaffolds	165:198	intricate and customized scaffolds that provide favored conditions for cell proliferation	165:253	3D bioprinting of hydrogels has gained great attention due to its potential to manufacture intricate and customized scaffolds that provide favored conditions for cell proliferation.
32790232	11	3	theme	hydrogels	1453:1461	arg1	development					1415:1425	the development	1411:1425	the development of advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues	1411:1540	Thus, this study is important for the development of advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues.
32790232	11	4	theme	biomedical	1500:1509	arg1	devices					1511:1517	biomedical devices	1500:1517	biomedical devices	1500:1517	Thus, this study is important for the development of advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues.
32790232	8	5	theme	electron	1120:1127	arg1	microscopy					1129:1138	scanning electron microscopy	1111:1138	scanning electron microscopy	1111:1138	Multilayer cylindrical structures are successfully 3D printed, and their porous structure is confirmed by scanning electron microscopy and Brunauer-Emmett-Teller surface area analyses.
32790232	5	6	theme	Physicochemical	615:629	arg1	components					656:665	the components	652:665	Physicochemical interactions between the components of the intertwined gelatin-cellulose-alginate network	615:719	Physicochemical interactions between the components of the intertwined gelatin-cellulose-alginate network are studied via altering copolymer ratios.
32790232	2	7	theme	printing	383:390	arg1	process					392:398	printing process	383:398	printing process	383:398	Nevertheless, plain natural hydrogels can be easily disintegrated, and their mechanical strengths are usually insufficient for printing process.
32790232	7	8	theme	different	939:947	arg1	strategies					962:971	two different crosslinking strategies	935:971	two different crosslinking strategies using glutaraldehyde or CaCl2	935:1001	The utility of this approach is examined with two different crosslinking strategies using glutaraldehyde or CaCl2 .
32790232	8	9	theme	Brunauer-Emmett-Teller	1144:1165	arg1	area					1175:1178	Brunauer-Emmett-Teller surface area	1144:1178	Brunauer-Emmett-Teller surface area	1144:1178	Multilayer cylindrical structures are successfully 3D printed, and their porous structure is confirmed by scanning electron microscopy and Brunauer-Emmett-Teller surface area analyses.
32790232	5	10	theme	interactions between	631:650	arg1	components					656:665	the components	652:665	Physicochemical interactions between the components of the intertwined gelatin-cellulose-alginate network	615:719	Physicochemical interactions between the components of the intertwined gelatin-cellulose-alginate network are studied via altering copolymer ratios.
32790232	1	11	theme	3D	74:75	arg1	bioprinting					77:87	3D bioprinting	74:87	3D bioprinting of hydrogels	74:100	3D bioprinting of hydrogels has gained great attention due to its potential to manufacture intricate and customized scaffolds that provide favored conditions for cell proliferation.
32790232	7	12	theme	crosslinking	949:960	arg1	strategies					962:971	two different crosslinking strategies	935:971	two different crosslinking strategies using glutaraldehyde or CaCl2	935:1001	The utility of this approach is examined with two different crosslinking strategies using glutaraldehyde or CaCl2 .
32790232	8	13	theme	Multilayer	1005:1014	arg1	structures					1028:1037	Multilayer cylindrical structures	1005:1037	Multilayer cylindrical structures	1005:1037	Multilayer cylindrical structures are successfully 3D printed, and their porous structure is confirmed by scanning electron microscopy and Brunauer-Emmett-Teller surface area analyses.
32790232	8	14	dep	microscopy	1129:1138	arg1	analyses					1180:1187	analyses	1180:1187	analyses	1180:1187	Multilayer cylindrical structures are successfully 3D printed, and their porous structure is confirmed by scanning electron microscopy and Brunauer-Emmett-Teller surface area analyses.
32790232	6	15	theme	degradation	864:874	arg1	experiments					876:886	infrared spectroscopy, swelling, and degradation experiments	827:886	infrared spectroscopy, swelling, and degradation experiments	827:886	The structure of the materials and porosity are assessed using infrared spectroscopy, swelling, and degradation experiments.
32790232	1	16	theme	customized	179:188	arg1	scaffolds					190:198	intricate and customized scaffolds	165:198	intricate and customized scaffolds that provide favored conditions for cell proliferation	165:253	3D bioprinting of hydrogels has gained great attention due to its potential to manufacture intricate and customized scaffolds that provide favored conditions for cell proliferation.
32790232	4	17	theme	3D	521:522	arg1	printing					524:531	extrusion-based 3D printing	505:531	extrusion-based 3D printing which is entirely composed of natural polymers, gelatin, alginate, and cellulose	505:612	This study aims to develop a hydrogel ink for extrusion-based 3D printing which is entirely composed of natural polymers, gelatin, alginate, and cellulose.
32790232	0	18	theme	Blend	57:61	arg1	Hydrogels					63:71	Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels	15:71	Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels	15:71	3D Printing of Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels.
32790232	1	19	theme	hydrogels	92:100	arg1	bioprinting					77:87	3D bioprinting	74:87	3D bioprinting of hydrogels	74:100	3D bioprinting of hydrogels has gained great attention due to its potential to manufacture intricate and customized scaffolds that provide favored conditions for cell proliferation.
32790232	11	20	theme	artificial	1523:1532	arg1	tissues					1534:1540	artificial tissues	1523:1540	artificial tissues	1523:1540	Thus, this study is important for the development of advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues.
32790232	11	21	theme	3D	1450:1451	arg1	hydrogels					1453:1461	advanced functional 3D hydrogels	1430:1461	advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues	1430:1540	Thus, this study is important for the development of advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues.
32790232	4	22	theme	extrusion-based	505:519	arg1	printing					524:531	extrusion-based 3D printing	505:531	extrusion-based 3D printing which is entirely composed of natural polymers, gelatin, alginate, and cellulose	505:612	This study aims to develop a hydrogel ink for extrusion-based 3D printing which is entirely composed of natural polymers, gelatin, alginate, and cellulose.
32790232	5	23	theme	intertwined	674:684	arg1	network					713:719	the intertwined gelatin-cellulose-alginate network	670:719	the intertwined gelatin-cellulose-alginate network	670:719	Physicochemical interactions between the components of the intertwined gelatin-cellulose-alginate network are studied via altering copolymer ratios.
32790232	0	24	theme	3D	0:1	arg1	Printing					3:10	3D Printing	0:10	3D Printing of Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels.	0:72	3D Printing of Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels.
32790232	5	25	theme	gelatin-cellulose-alginate	686:711	arg1	network					713:719	the intertwined gelatin-cellulose-alginate network	670:719	the intertwined gelatin-cellulose-alginate network	670:719	Physicochemical interactions between the components of the intertwined gelatin-cellulose-alginate network are studied via altering copolymer ratios.
32790232	6	26	theme	swelling	850:857	arg1	experiments					876:886	infrared spectroscopy, swelling, and degradation experiments	827:886	infrared spectroscopy, swelling, and degradation experiments	827:886	The structure of the materials and porosity are assessed using infrared spectroscopy, swelling, and degradation experiments.
32790232	2	27	theme	mechanical	333:342	arg1	strengths					344:352	their mechanical strengths	327:352	their mechanical strengths	327:352	Nevertheless, plain natural hydrogels can be easily disintegrated, and their mechanical strengths are usually insufficient for printing process.
32790232	0	28	theme	Cytocompatible	15:28	arg1	Hydrogels					63:71	Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels	15:71	Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels	15:71	3D Printing of Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels.
32790232	8	29	theme	scanning	1111:1118	arg1	microscopy					1129:1138	scanning electron microscopy	1111:1138	scanning electron microscopy	1111:1138	Multilayer cylindrical structures are successfully 3D printed, and their porous structure is confirmed by scanning electron microscopy and Brunauer-Emmett-Teller surface area analyses.
32790232	8	30	theme	porous	1078:1083	arg1	structure					1085:1093	their porous structure	1072:1093	their porous structure	1072:1093	Multilayer cylindrical structures are successfully 3D printed, and their porous structure is confirmed by scanning electron microscopy and Brunauer-Emmett-Teller surface area analyses.
32790232	1	31	theme	great	113:117	arg1	attention					119:127	great attention	113:127	great attention due to its potential to manufacture intricate and customized scaffolds that provide favored conditions for cell proliferation	113:253	3D bioprinting of hydrogels has gained great attention due to its potential to manufacture intricate and customized scaffolds that provide favored conditions for cell proliferation.
32790232	7	32	theme	approach	909:916	arg1	utility					893:899	The utility	889:899	The utility of this approach	889:916	The utility of this approach is examined with two different crosslinking strategies using glutaraldehyde or CaCl2 .
32790232	1	33	theme	favored	213:219	arg1	conditions					221:230	favored conditions	213:230	favored conditions for cell proliferation	213:253	3D bioprinting of hydrogels has gained great attention due to its potential to manufacture intricate and customized scaffolds that provide favored conditions for cell proliferation.
32790232	3	34	theme	composite	408:416	arg1	hydrogels					418:426	composite hydrogels	408:426	composite hydrogels	408:426	Hence, composite hydrogels are developed for 3D printing.
32790232	9	35	theme	scaffolds	1234:1242	arg1	cytocompatibility					1200:1216	cytocompatibility	1200:1216	cytocompatibility of the hydrogel scaffolds	1200:1242	Moreover, cytocompatibility of the hydrogel scaffolds is confirmed on fibroblast cells.
32790232	3	36	theme	3D	446:447	arg1	printing					449:456	3D printing	446:456	3D printing	446:456	Hence, composite hydrogels are developed for 3D printing.
32790232	11	37	contain	have	1468:1471	arg2	potential					1486:1494	considerable potential	1473:1494	considerable potential for biomedical devices and artificial tissues	1473:1540	Thus, this study is important for the development of advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues.
32790232	11	37	contain	have	1468:1471	arg1	hydrogels					1453:1461	advanced functional 3D hydrogels	1430:1461	advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues	1430:1540	Thus, this study is important for the development of advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues.
32790232	0	38	theme	Gelatin-Cellulose-Alginate	30:55	arg1	Hydrogels					63:71	Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels	15:71	Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels	15:71	3D Printing of Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels.
32790232	4	39	theme	hydrogel	488:495	arg1	ink					497:499	a hydrogel ink	486:499	a hydrogel ink for extrusion-based 3D printing which is entirely composed of natural polymers, gelatin, alginate, and cellulose	486:612	This study aims to develop a hydrogel ink for extrusion-based 3D printing which is entirely composed of natural polymers, gelatin, alginate, and cellulose.
32790232	11	40	theme	advanced	1430:1437	arg1	hydrogels					1453:1461	advanced functional 3D hydrogels	1430:1461	advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues	1430:1540	Thus, this study is important for the development of advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues.
32790232	6	41	theme	spectroscopy	836:847	arg1	experiments					876:886	infrared spectroscopy, swelling, and degradation experiments	827:886	infrared spectroscopy, swelling, and degradation experiments	827:886	The structure of the materials and porosity are assessed using infrared spectroscopy, swelling, and degradation experiments.
32790232	1	42	theme	cell	236:239	arg1	proliferation					241:253	cell proliferation	236:253	cell proliferation	236:253	3D bioprinting of hydrogels has gained great attention due to its potential to manufacture intricate and customized scaffolds that provide favored conditions for cell proliferation.
32790232	11	43	theme	functional	1439:1448	arg1	hydrogels					1453:1461	advanced functional 3D hydrogels	1430:1461	advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues	1430:1540	Thus, this study is important for the development of advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues.
32790232	10	44	theme	developed	1282:1290	arg1	natural					1315:1321	natural	1315:1321	natural	1315:1321	The developed material is completely natural, biocompatible, economical, and the method is facile.
32790232	10	44	theme	developed	1282:1290	arg1	material					1292:1299	The developed material	1278:1299	The developed material	1278:1299	The developed material is completely natural, biocompatible, economical, and the method is facile.
32790232	6	45	theme	infrared	827:834	arg1	spectroscopy					836:847	infrared spectroscopy	827:847	infrared spectroscopy	827:847	The structure of the materials and porosity are assessed using infrared spectroscopy, swelling, and degradation experiments.
32790232	1	46	theme	due	129:131	arg1	attention					119:127	great attention	113:127	great attention due to its potential to manufacture intricate and customized scaffolds that provide favored conditions for cell proliferation	113:253	3D bioprinting of hydrogels has gained great attention due to its potential to manufacture intricate and customized scaffolds that provide favored conditions for cell proliferation.
32790232	0	47	theme	Hydrogels	63:71	arg1	Printing					3:10	3D Printing	0:10	3D Printing of Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels.	0:72	3D Printing of Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels.
32790232	5	48	theme	copolymer	746:754	arg1	ratios					756:761	copolymer ratios	746:761	copolymer ratios	746:761	Physicochemical interactions between the components of the intertwined gelatin-cellulose-alginate network are studied via altering copolymer ratios.
32790232	8	49	theme	surface	1167:1173	arg1	area					1175:1178	Brunauer-Emmett-Teller surface area	1144:1178	Brunauer-Emmett-Teller surface area	1144:1178	Multilayer cylindrical structures are successfully 3D printed, and their porous structure is confirmed by scanning electron microscopy and Brunauer-Emmett-Teller surface area analyses.
32790232	9	50	theme	fibroblast	1260:1269	arg1	cells					1271:1275	fibroblast cells	1260:1275	fibroblast cells	1260:1275	Moreover, cytocompatibility of the hydrogel scaffolds is confirmed on fibroblast cells.
32790232	4	51	theme	natural	563:569	arg1	polymers					571:578	natural polymers	563:578	natural polymers	563:578	This study aims to develop a hydrogel ink for extrusion-based 3D printing which is entirely composed of natural polymers, gelatin, alginate, and cellulose.
32790232	11	52	theme	considerable	1473:1484	arg1	potential					1486:1494	considerable potential	1473:1494	considerable potential for biomedical devices and artificial tissues	1473:1540	Thus, this study is important for the development of advanced functional 3D hydrogels that have considerable potential for biomedical devices and artificial tissues.
32790232	8	53	theme	cylindrical	1016:1026	arg1	structures					1028:1037	Multilayer cylindrical structures	1005:1037	Multilayer cylindrical structures	1005:1037	Multilayer cylindrical structures are successfully 3D printed, and their porous structure is confirmed by scanning electron microscopy and Brunauer-Emmett-Teller surface area analyses.
32790232	9	54	theme	hydrogel	1225:1232	arg1	scaffolds					1234:1242	the hydrogel scaffolds	1221:1242	the hydrogel scaffolds	1221:1242	Moreover, cytocompatibility of the hydrogel scaffolds is confirmed on fibroblast cells.
32790232	8	55	dep	3D	1056:1057	arg1	printed					1059:1065	printed	1059:1065	are successfully 3D printed	1039:1065	Multilayer cylindrical structures are successfully 3D printed, and their porous structure is confirmed by scanning electron microscopy and Brunauer-Emmett-Teller surface area analyses.
32790232	2	56	theme	natural	276:282	arg1	hydrogels					284:292	plain natural hydrogels	270:292	plain natural hydrogels	270:292	Nevertheless, plain natural hydrogels can be easily disintegrated, and their mechanical strengths are usually insufficient for printing process.
32790232	6	57	theme	porosity	799:806	arg1	structure					768:776	The structure	764:776	The structure of the materials and porosity	764:806	The structure of the materials and porosity are assessed using infrared spectroscopy, swelling, and degradation experiments.
32790232	2	58	theme	plain	270:274	arg1	hydrogels					284:292	plain natural hydrogels	270:292	plain natural hydrogels	270:292	Nevertheless, plain natural hydrogels can be easily disintegrated, and their mechanical strengths are usually insufficient for printing process.
34893233	0	0	theme	alcohol-induced	107:121	arg1	injury					139:144	alcohol-induced gastric mucosal injury	107:144	alcohol-induced gastric mucosal injury	107:144	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.
34893233	9	1	from	candidate	1341:1349	arg1	conclusion					1299:1308	conclusion	1299:1308	conclusion	1299:1308	In conclusion, CS-NAC/ALG/TCP is a promising candidate for the treatment of alcohol-induced gastric injury.
34893233	6	2	theme	stress	789:794	arg1	status					796:801	the oxidative stress status	775:801	the oxidative stress status of the gastric mucosa	775:823	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.
34893233	8	3	theme	enzymes	1222:1228	arg1	activities					1189:1198	the activities	1185:1198	the activities of alcohol metabolism enzymes	1185:1228	Besides, CS-NAC/ALG/TCP can also increase the activities of alcohol metabolism enzymes to improve alcohol metabolism, thereby reducing alcoholic damage.
34893233	4	4	theme	mucosal	451:457	arg1	models					466:471	The alcohol-induced gastric mucosal injury models	423:471	The alcohol-induced gastric mucosal injury models in mice	423:479	The alcohol-induced gastric mucosal injury models in mice were established to evaluate the protective effects of CS-NAC/ALG/TCP.
34893233	0	5	theme	mucosal	131:137	arg1	injury					139:144	alcohol-induced gastric mucosal injury	107:144	alcohol-induced gastric mucosal injury	107:144	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.
34893233	7	6	theme	gastric	1119:1125	arg1	injury					1135:1140	the gastric mucosal injury	1115:1140	the gastric mucosal injury	1115:1140	It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury.
34893233	4	7	theme	gastric	443:449	arg1	models					466:471	The alcohol-induced gastric mucosal injury models	423:471	The alcohol-induced gastric mucosal injury models in mice	423:479	The alcohol-induced gastric mucosal injury models in mice were established to evaluate the protective effects of CS-NAC/ALG/TCP.
34893233	2	8	theme	collagen	328:335	arg1	CS-NAC/ALG/TCP					346:359	CS-NAC/ALG/TCP	346:359	CS-NAC/ALG/TCP	346:359	In this paper, the gastric acid-responsive hydrogel of CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP) was developed.
34893233	2	8	theme	collagen	328:335	arg1	peptide					337:343	CS-NAC/alginate/tilapia collagen peptide	304:343	CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP)	304:360	In this paper, the gastric acid-responsive hydrogel of CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP) was developed.
34893233	7	9	theme	protective	993:1002	arg1	factors					1004:1010	gastric protective factors	985:1010	gastric protective factors such as PGE2	985:1023	It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury.
34893233	7	9	theme	protective	993:1002	arg1	PGE2					1020:1023	PGE2	1020:1023	PGE2	1020:1023	It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury.
34893233	0	10	theme	gastric	123:129	arg1	injury					139:144	alcohol-induced gastric mucosal injury	107:144	alcohol-induced gastric mucosal injury	107:144	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.
34893233	9	11	theme	promising	1331:1339	arg1	candidate					1341:1349	a promising candidate	1329:1349	a promising candidate for the treatment of alcohol-induced gastric injury	1329:1401	In conclusion, CS-NAC/ALG/TCP is a promising candidate for the treatment of alcohol-induced gastric injury.
34893233	9	11	theme	promising	1331:1339	arg1	CS-NAC/ALG/TCP					1311:1324	CS-NAC/ALG/TCP	1311:1324	CS-NAC/ALG/TCP	1311:1324	In conclusion, CS-NAC/ALG/TCP is a promising candidate for the treatment of alcohol-induced gastric injury.
34893233	7	12	theme	mucosal	1127:1133	arg1	injury					1135:1140	the gastric mucosal injury	1115:1140	the gastric mucosal injury	1115:1140	It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury.
34893233	5	13	theme	strong	662:667	arg1	mucoadhesion					669:680	strong mucoadhesion	662:680	strong mucoadhesion	662:680	The results showed that CS-NAC/ALG/TCP was successfully fabricated, and it showed a sustained release of TCP, strong mucoadhesion, and excellent biodegradability in vitro.
34893233	2	14	theme	CS-NAC/alginate/tilapia	304:326	arg1	CS-NAC/ALG/TCP					346:359	CS-NAC/ALG/TCP	346:359	CS-NAC/ALG/TCP	346:359	In this paper, the gastric acid-responsive hydrogel of CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP) was developed.
34893233	2	14	theme	CS-NAC/alginate/tilapia	304:326	arg1	peptide					337:343	CS-NAC/alginate/tilapia collagen peptide	304:343	CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP)	304:360	In this paper, the gastric acid-responsive hydrogel of CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP) was developed.
34893233	6	15	theme	oxidative	779:787	arg1	status					796:801	the oxidative stress status	775:801	the oxidative stress status of the gastric mucosa	775:823	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.
34893233	4	16	theme	injury	459:464	arg1	models					466:471	The alcohol-induced gastric mucosal injury models	423:471	The alcohol-induced gastric mucosal injury models in mice	423:479	The alcohol-induced gastric mucosal injury models in mice were established to evaluate the protective effects of CS-NAC/ALG/TCP.
34893233	8	17	theme	alcoholic	1278:1286	arg1	damage					1288:1293	alcoholic damage	1278:1293	alcoholic damage	1278:1293	Besides, CS-NAC/ALG/TCP can also increase the activities of alcohol metabolism enzymes to improve alcohol metabolism, thereby reducing alcoholic damage.
34893233	4	18	from	models	466:471	arg1	mice					476:479	mice	476:479	mice	476:479	The alcohol-induced gastric mucosal injury models in mice were established to evaluate the protective effects of CS-NAC/ALG/TCP.
34893233	8	19	theme	alcohol	1241:1247	arg1	metabolism					1249:1258	alcohol metabolism	1241:1258	alcohol metabolism	1241:1258	Besides, CS-NAC/ALG/TCP can also increase the activities of alcohol metabolism enzymes to improve alcohol metabolism, thereby reducing alcoholic damage.
34893233	6	20	theme	SOD	853:855	arg1	levels					843:848	the levels	839:848	the levels of SOD, GSH, and CAT in tissues	839:880	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.
34893233	4	21	theme	protective	514:523	arg1	effects					525:531	the protective effects	510:531	the protective effects of CS-NAC/ALG/TCP	510:549	The alcohol-induced gastric mucosal injury models in mice were established to evaluate the protective effects of CS-NAC/ALG/TCP.
34893233	0	22	theme	acid-response	8:20	arg1	hydrogel					75:82	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel	0:82	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.	0:145	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.
34893233	4	23	theme	CS-NAC/ALG/TCP	536:549	arg1	effects					525:531	the protective effects	510:531	the protective effects of CS-NAC/ALG/TCP	510:549	The alcohol-induced gastric mucosal injury models in mice were established to evaluate the protective effects of CS-NAC/ALG/TCP.
34893233	5	24	theme	excellent	687:695	arg1	biodegradability					697:712	excellent biodegradability	687:712	excellent biodegradability	687:712	The results showed that CS-NAC/ALG/TCP was successfully fabricated, and it showed a sustained release of TCP, strong mucoadhesion, and excellent biodegradability in vitro.
34893233	5	25	theme	sustained	636:644	arg1	release					646:652	a sustained release	634:652	a sustained release of TCP, strong mucoadhesion, and excellent biodegradability	634:712	The results showed that CS-NAC/ALG/TCP was successfully fabricated, and it showed a sustained release of TCP, strong mucoadhesion, and excellent biodegradability in vitro.
34893233	1	26	theme	gastric	212:218	arg1	ulcer					220:224	gastric ulcer	212:224	gastric ulcer	212:224	Long-term excessive alcohol intake can easily lead to gastritis, gastric ulcer, and gastric bleeding.
34893233	0	27	theme	Gastric	0:6	arg1	hydrogel					75:82	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel	0:82	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.	0:145	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.
34893233	5	28	theme	biodegradability	697:712	arg1	release					646:652	a sustained release	634:652	a sustained release of TCP, strong mucoadhesion, and excellent biodegradability	634:712	The results showed that CS-NAC/ALG/TCP was successfully fabricated, and it showed a sustained release of TCP, strong mucoadhesion, and excellent biodegradability in vitro.
34893233	4	29	theme	alcohol-induced	427:441	arg1	models					466:471	The alcohol-induced gastric mucosal injury models	423:471	The alcohol-induced gastric mucosal injury models in mice	423:479	The alcohol-induced gastric mucosal injury models in mice were established to evaluate the protective effects of CS-NAC/ALG/TCP.
34893233	0	30	theme	collagen	48:55	arg1	hydrogel					75:82	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel	0:82	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.	0:145	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.
34893233	5	31	theme	mucoadhesion	669:680	arg1	release					646:652	a sustained release	634:652	a sustained release of TCP, strong mucoadhesion, and excellent biodegradability	634:712	The results showed that CS-NAC/ALG/TCP was successfully fabricated, and it showed a sustained release of TCP, strong mucoadhesion, and excellent biodegradability in vitro.
34893233	5	32	theme	TCP	657:659	arg1	release					646:652	a sustained release	634:652	a sustained release of TCP, strong mucoadhesion, and excellent biodegradability	634:712	The results showed that CS-NAC/ALG/TCP was successfully fabricated, and it showed a sustained release of TCP, strong mucoadhesion, and excellent biodegradability in vitro.
34893233	6	33	from	levels	843:848	arg1	tissues					874:880	tissues	874:880	tissues	874:880	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.
34893233	0	34	theme	chitosan/alginate/tilapia	22:46	arg1	hydrogel					75:82	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel	0:82	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.	0:145	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.
34893233	9	35	theme	alcohol-induced	1372:1386	arg1	injury					1396:1401	alcohol-induced gastric injury	1372:1401	alcohol-induced gastric injury	1372:1401	In conclusion, CS-NAC/ALG/TCP is a promising candidate for the treatment of alcohol-induced gastric injury.
34893233	7	36	theme	alcohol-induced	1071:1085	arg1	inflammation					1087:1098	the alcohol-induced inflammation	1067:1098	the alcohol-induced inflammation	1067:1098	It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury.
34893233	2	37	theme	peptide	337:343	arg1	hydrogel					292:299	the gastric acid-responsive hydrogel	264:299	the gastric acid-responsive hydrogel of CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP)	264:360	In this paper, the gastric acid-responsive hydrogel of CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP) was developed.
34893233	6	38	theme	animal	731:736	arg1	experiments					738:748	the animal experiments	727:748	the animal experiments	727:748	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.
34893233	0	39	theme	composite	65:73	arg1	hydrogel					75:82	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel	0:82	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.	0:145	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.
34893233	9	40	theme	gastric	1388:1394	arg1	injury					1396:1401	alcohol-induced gastric injury	1372:1401	alcohol-induced gastric injury	1372:1401	In conclusion, CS-NAC/ALG/TCP is a promising candidate for the treatment of alcohol-induced gastric injury.
34893233	6	41	from	SOD	853:855	arg1	tissues					874:880	tissues	874:880	tissues	874:880	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.
34893233	0	42	theme	peptide	57:63	arg1	hydrogel					75:82	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel	0:82	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.	0:145	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.
34893233	9	43	theme	injury	1396:1401	arg1	treatment					1359:1367	the treatment	1355:1367	the treatment of alcohol-induced gastric injury	1355:1401	In conclusion, CS-NAC/ALG/TCP is a promising candidate for the treatment of alcohol-induced gastric injury.
34893233	6	44	from	CAT	867:869	arg1	tissues					874:880	tissues	874:880	tissues	874:880	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.
34893233	0	45	from	effects	96:102	arg1	injury					139:144	alcohol-induced gastric mucosal injury	107:144	alcohol-induced gastric mucosal injury	107:144	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.
34893233	0	46	dep	hydrogel	75:82	arg1	effects					96:102	Protection effects	85:102	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.	0:145	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.
34893233	6	47	theme	GSH	858:860	arg1	levels					843:848	the levels	839:848	the levels of SOD, GSH, and CAT in tissues	839:880	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.
34893233	1	48	theme	Long-term	147:155	arg1	intake					175:180	Long-term excessive alcohol intake	147:180	Long-term excessive alcohol intake	147:180	Long-term excessive alcohol intake can easily lead to gastritis, gastric ulcer, and gastric bleeding.
34893233	6	49	from	tissues	874:880	arg1	levels					843:848	the levels	839:848	the levels of SOD, GSH, and CAT in tissues	839:880	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.
34893233	6	50	from	GSH	858:860	arg1	tissues					874:880	tissues	874:880	tissues	874:880	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.
34893233	6	51	theme	mucosa	818:823	arg1	status					796:801	the oxidative stress status	775:801	the oxidative stress status of the gastric mucosa	775:823	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.
34893233	1	52	theme	excessive	157:165	arg1	intake					175:180	Long-term excessive alcohol intake	147:180	Long-term excessive alcohol intake	147:180	Long-term excessive alcohol intake can easily lead to gastritis, gastric ulcer, and gastric bleeding.
34893233	7	53	theme	IL-1β	936:940	arg1	expression					910:919	the expression	906:919	the expression of MPO, TNF-α, IL-1β, and IL-6	906:950	It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury.
34893233	7	54	theme	IL-6	947:950	arg1	expression					910:919	the expression	906:919	the expression of MPO, TNF-α, IL-1β, and IL-6	906:950	It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury.
34893233	2	55	theme	acid-responsive	276:290	arg1	hydrogel					292:299	the gastric acid-responsive hydrogel	264:299	the gastric acid-responsive hydrogel of CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP)	264:360	In this paper, the gastric acid-responsive hydrogel of CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP) was developed.
34893233	6	56	theme	gastric	810:816	arg1	mucosa					818:823	the gastric mucosa	806:823	the gastric mucosa	806:823	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.
34893233	1	57	theme	alcohol	167:173	arg1	intake					175:180	Long-term excessive alcohol intake	147:180	Long-term excessive alcohol intake	147:180	Long-term excessive alcohol intake can easily lead to gastritis, gastric ulcer, and gastric bleeding.
34893233	7	58	theme	mouse	1035:1039	arg1	stomach					1041:1047	mouse stomach	1035:1047	mouse stomach	1035:1047	It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury.
34893233	2	59	theme	gastric	268:274	arg1	hydrogel					292:299	the gastric acid-responsive hydrogel	264:299	the gastric acid-responsive hydrogel of CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP)	264:360	In this paper, the gastric acid-responsive hydrogel of CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP) was developed.
34893233	7	60	theme	factors	1004:1010	arg1	production					971:980	the production	967:980	the production of gastric protective factors such as PGE2	967:1023	It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury.
34893233	7	61	theme	TNF-α	929:933	arg1	expression					910:919	the expression	906:919	the expression of MPO, TNF-α, IL-1β, and IL-6	906:950	It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury.
34893233	6	62	theme	CAT	867:869	arg1	levels					843:848	the levels	839:848	the levels of SOD, GSH, and CAT in tissues	839:880	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.
34893233	0	63	theme	Protection	85:94	arg1	effects					96:102	Protection effects	85:102	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.	0:145	Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury.
34893233	8	64	theme	metabolism	1211:1220	arg1	enzymes					1222:1228	alcohol metabolism enzymes	1203:1228	alcohol metabolism enzymes	1203:1228	Besides, CS-NAC/ALG/TCP can also increase the activities of alcohol metabolism enzymes to improve alcohol metabolism, thereby reducing alcoholic damage.
34893233	7	65	theme	gastric	985:991	arg1	factors					1004:1010	gastric protective factors	985:1010	gastric protective factors such as PGE2	985:1023	It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury.
34893233	7	65	theme	gastric	985:991	arg1	PGE2					1020:1023	PGE2	1020:1023	PGE2	1020:1023	It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury.
34893233	8	66	theme	alcohol	1203:1209	arg1	enzymes					1222:1228	alcohol metabolism enzymes	1203:1228	alcohol metabolism enzymes	1203:1228	Besides, CS-NAC/ALG/TCP can also increase the activities of alcohol metabolism enzymes to improve alcohol metabolism, thereby reducing alcoholic damage.
34893233	7	67	theme	MPO	924:926	arg1	expression					910:919	the expression	906:919	the expression of MPO, TNF-α, IL-1β, and IL-6	906:950	It also down-regulated the expression of MPO, TNF-α, IL-1β, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury.
34224705	12	0	theme	eco-friendly	1596:1607	arg1	This					1572:1575	This	1572:1575	This	1572:1575	This is a non-toxic and eco-friendly approach.
34224705	12	0	theme	eco-friendly	1596:1607	arg1	approach					1609:1616	a non-toxic and eco-friendly approach	1580:1616	a non-toxic and eco-friendly approach	1580:1616	This is a non-toxic and eco-friendly approach.
34224705	5	1	theme	volume	645:650	arg1	ratio					656:660	volume (V) ratio	645:660	volume (V) ratio that is one of the peculiar characteristics of nanoparticles	645:721	This sustains the enhancement in surface area (SA) to volume (V) ratio that is one of the peculiar characteristics of nanoparticles.
34224705	5	2	from	enhancement	609:619	arg1	SA					638:639	SA	638:639	SA	638:639	This sustains the enhancement in surface area (SA) to volume (V) ratio that is one of the peculiar characteristics of nanoparticles.
34224705	5	2	from	enhancement	609:619	arg1	area					632:635	surface area	624:635	surface area (SA)	624:640	This sustains the enhancement in surface area (SA) to volume (V) ratio that is one of the peculiar characteristics of nanoparticles.
34224705	8	3	theme	bacteria	1087:1094	arg1	growth					1077:1082	the growth	1073:1082	the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water	1073:1194	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	10	4	theme	nanoparticles	1364:1376	arg1	action					1341:1346	The photocatalytic action	1322:1346	The photocatalytic action of the obtained nanoparticles	1322:1376	The photocatalytic action of the obtained nanoparticles increases with decreasing average particle size.
34224705	2	5	theme	compositional	344:356	arg1	studies					374:380	The structural, morphological, optical, compositional and vibrational studies	304:380	The structural, morphological, optical, compositional and vibrational studies for the AuNPs and β-CD/AuNPs	304:409	The structural, morphological, optical, compositional and vibrational studies for the AuNPs and β-CD/AuNPs were carried out.
34224705	11	6	theme	dyeing	1488:1493	arg1	water					1501:1505	textile dyeing waste water	1480:1505	textile dyeing waste water in presence of AuNPs	1480:1526	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and β-CD/AuNPs was 0.005/min.
34224705	8	7	theme	soluble	1001:1007	arg1	nanoparticles					1009:1021	these water soluble nanoparticles	989:1021	these water soluble nanoparticles	989:1021	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	0	8	theme	heavy	90:94	arg1	metals					96:101	heavy metals	90:101	heavy metals	90:101	Functionalization of gold nanoparticles by β-cyclodextrin as a probe for the detection of heavy metals in water and photocatalytic degradation of textile dye.
34224705	4	9	theme	absorption	513:522	arg1	spectra					524:530	The UV-visible absorption spectra	498:530	The UV-visible absorption spectra	498:530	The UV-visible absorption spectra exhibit a red-shift with decreasing average particle size.
34224705	8	10	theme	small	959:963	arg1	nanoparticles					971:983	uniform small sized nanoparticles	951:983	uniform small sized nanoparticles	951:983	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	7	11	theme	improved	857:864	arg1	distribution					866:877	improved distribution	857:877	improved distribution	857:877	Also it shows a decrease in average particle size and improved distribution.
34224705	5	12	theme	nanoparticles	709:721	arg1	characteristics					690:704	the peculiar characteristics	677:704	the peculiar characteristics of nanoparticles	677:721	This sustains the enhancement in surface area (SA) to volume (V) ratio that is one of the peculiar characteristics of nanoparticles.
34224705	10	13	theme	particle	1412:1419	arg1	size					1421:1424	average particle size	1404:1424	average particle size	1404:1424	The photocatalytic action of the obtained nanoparticles increases with decreasing average particle size.
34224705	5	14	theme	surface	624:630	arg1	SA					638:639	SA	638:639	SA	638:639	This sustains the enhancement in surface area (SA) to volume (V) ratio that is one of the peculiar characteristics of nanoparticles.
34224705	5	14	theme	surface	624:630	arg1	area					632:635	surface area	624:635	surface area (SA)	624:640	This sustains the enhancement in surface area (SA) to volume (V) ratio that is one of the peculiar characteristics of nanoparticles.
34224705	11	15	theme	kapp	1431:1434	arg1	value					1436:1440	The kapp value	1427:1440	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs	1427:1526	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and β-CD/AuNPs was 0.005/min.
34224705	11	15	theme	kapp	1431:1434	arg1	0.002/min					1532:1540	0.002/min	1532:1540	0.002/min	1532:1540	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and β-CD/AuNPs was 0.005/min.
34224705	7	16	theme	particle	839:846	arg1	size					848:851	average particle size	831:851	average particle size	831:851	Also it shows a decrease in average particle size and improved distribution.
34224705	2	17	theme	morphological	320:332	arg1	studies					374:380	The structural, morphological, optical, compositional and vibrational studies	304:380	The structural, morphological, optical, compositional and vibrational studies for the AuNPs and β-CD/AuNPs	304:409	The structural, morphological, optical, compositional and vibrational studies for the AuNPs and β-CD/AuNPs were carried out.
34224705	8	18	theme	good	1033:1036	arg1	action					1052:1057	very good antibacterial action	1028:1057	very good antibacterial action	1028:1057	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	8	19	theme	uniform	951:957	arg1	nanoparticles					971:983	uniform small sized nanoparticles	951:983	uniform small sized nanoparticles	951:983	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	11	20	from	water	1501:1505	arg1	presence					1510:1517	presence	1510:1517	presence of AuNPs	1510:1526	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and β-CD/AuNPs was 0.005/min.
34224705	8	21	theme	toxic	1174:1178	arg1	metals					1180:1185	toxic metals	1174:1185	toxic metals in water	1174:1194	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	1	22	theme	Gold	159:162	arg1	AuNPs					179:183	AuNPs	179:183	AuNPs	179:183	Gold nanoparticles (AuNPs) and AuNPs functionalized by β-cyclodextrin (β-CD/AuNPs) were prepared successfully through chemical reduction method.
34224705	1	22	theme	Gold	159:162	arg1	nanoparticles					164:176	Gold nanoparticles	159:176	Gold nanoparticles (AuNPs)	159:184	Gold nanoparticles (AuNPs) and AuNPs functionalized by β-cyclodextrin (β-CD/AuNPs) were prepared successfully through chemical reduction method.
34224705	0	23	theme	metals	96:101	arg1	detection					77:85	the detection	73:85	the detection of heavy metals in water	73:110	Functionalization of gold nanoparticles by β-cyclodextrin as a probe for the detection of heavy metals in water and photocatalytic degradation of textile dye.
34224705	8	24	from	water	1190:1194	arg1	concentration					1157:1169	the concentration	1153:1169	the concentration of toxic metals in water	1153:1194	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	10	25	theme	average	1404:1410	arg1	size					1421:1424	average particle size	1404:1424	average particle size	1404:1424	The photocatalytic action of the obtained nanoparticles increases with decreasing average particle size.
34224705	12	26	theme	non-toxic	1582:1590	arg1	This					1572:1575	This	1572:1575	This	1572:1575	This is a non-toxic and eco-friendly approach.
34224705	12	26	theme	non-toxic	1582:1590	arg1	approach					1609:1616	a non-toxic and eco-friendly approach	1580:1616	a non-toxic and eco-friendly approach	1580:1616	This is a non-toxic and eco-friendly approach.
34224705	3	27	theme	AuNPs	450:454	arg1	Functionalization					429:445	Functionalization	429:445	Functionalization of AuNPs by β-CD	429:462	Functionalization of AuNPs by β-CD was confirmed with FT-IR results.
34224705	8	28	dep	water	1114:1118	arg1	activity					1132:1139	activity	1132:1139	activity	1132:1139	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	8	29	theme	sized	965:969	arg1	nanoparticles					971:983	uniform small sized nanoparticles	951:983	uniform small sized nanoparticles	951:983	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	7	30	theme	average	831:837	arg1	size					848:851	average particle size	831:851	average particle size	831:851	Also it shows a decrease in average particle size and improved distribution.
34224705	11	31	theme	textile	1480:1486	arg1	water					1501:1505	textile dyeing waste water	1480:1505	textile dyeing waste water in presence of AuNPs	1480:1526	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and β-CD/AuNPs was 0.005/min.
34224705	4	32	theme	average	568:574	arg1	size					585:588	average particle size	568:588	average particle size	568:588	The UV-visible absorption spectra exhibit a red-shift with decreasing average particle size.
34224705	8	33	theme	antibacterial	1038:1050	arg1	action					1052:1057	very good antibacterial action	1028:1057	very good antibacterial action	1028:1057	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	10	34	theme	photocatalytic	1326:1339	arg1	action					1341:1346	The photocatalytic action	1322:1346	The photocatalytic action of the obtained nanoparticles	1322:1376	The photocatalytic action of the obtained nanoparticles increases with decreasing average particle size.
34224705	2	35	theme	structural	308:317	arg1	studies					374:380	The structural, morphological, optical, compositional and vibrational studies	304:380	The structural, morphological, optical, compositional and vibrational studies for the AuNPs and β-CD/AuNPs	304:409	The structural, morphological, optical, compositional and vibrational studies for the AuNPs and β-CD/AuNPs were carried out.
34224705	6	36	dep	assembled	792:800	arg1	self					787:790	self	787:790	self	787:790	TEM results show that β-CD/AuNPs formed were monodispersed and self assembled.
34224705	8	37	theme	metals	1180:1185	arg1	concentration					1157:1169	the concentration	1153:1169	the concentration of toxic metals in water	1153:1194	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	1	38	theme	chemical	277:284	arg1	reduction					286:294	chemical reduction	277:294	chemical reduction method	277:301	Gold nanoparticles (AuNPs) and AuNPs functionalized by β-cyclodextrin (β-CD/AuNPs) were prepared successfully through chemical reduction method.
34224705	11	39	theme	AuNPs	1522:1526	arg1	presence					1510:1517	presence	1510:1517	presence of AuNPs	1510:1526	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and β-CD/AuNPs was 0.005/min.
34224705	0	40	theme	gold	21:24	arg1	Functionalization					0:16	Functionalization	0:16	Functionalization of gold	0:24	Functionalization of gold nanoparticles by β-cyclodextrin as a probe for the detection of heavy metals in water and photocatalytic degradation of textile dye.
34224705	1	41	theme	reduction	286:294	arg1	method					296:301	chemical reduction method	277:301	chemical reduction method	277:301	Gold nanoparticles (AuNPs) and AuNPs functionalized by β-cyclodextrin (β-CD/AuNPs) were prepared successfully through chemical reduction method.
34224705	0	42	from	detection	77:85	arg1	water					106:110	water	106:110	water	106:110	Functionalization of gold nanoparticles by β-cyclodextrin as a probe for the detection of heavy metals in water and photocatalytic degradation of textile dye.
34224705	8	43	located	found	1105:1109	arg2	bacteria					1087:1094	bacteria	1087:1094	bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water	1087:1194	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	8	43	located	found	1105:1109	arg1	sensing					1124:1130	sensing	1124:1130	sensing	1124:1130	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	8	43	located	found	1105:1109	arg1	water					1114:1118	water	1114:1118	water	1114:1118	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	8	44	theme	β-CD	891:894	arg1	use					884:886	The use	880:886	The use of β-CD in the synthesis of AuNPs	880:920	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	8	45	contain	have	1023:1026	arg1	nanoparticles					1009:1021	these water soluble nanoparticles	989:1021	these water soluble nanoparticles	989:1021	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	8	45	contain	have	1023:1026	arg2	action					1052:1057	very good antibacterial action	1028:1057	very good antibacterial action	1028:1057	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	4	46	theme	particle	576:583	arg1	size					585:588	average particle size	568:588	average particle size	568:588	The UV-visible absorption spectra exhibit a red-shift with decreasing average particle size.
34224705	5	47	theme	peculiar	681:688	arg1	characteristics					690:704	the peculiar characteristics	677:704	the peculiar characteristics of nanoparticles	677:721	This sustains the enhancement in surface area (SA) to volume (V) ratio that is one of the peculiar characteristics of nanoparticles.
34224705	8	48	dep	only	939:942	arg1	not					935:937	not	935:937	not	935:937	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	0	49	theme	photocatalytic	116:129	arg1	degradation					131:141	photocatalytic degradation	116:141	photocatalytic degradation of textile dye	116:156	Functionalization of gold nanoparticles by β-cyclodextrin as a probe for the detection of heavy metals in water and photocatalytic degradation of textile dye.
34224705	0	50	theme	textile	146:152	arg1	dye					154:156	textile dye	146:156	textile dye	146:156	Functionalization of gold nanoparticles by β-cyclodextrin as a probe for the detection of heavy metals in water and photocatalytic degradation of textile dye.
34224705	9	51	theme	system	1220:1225	arg1	1.788/mM					1274:1281	1.788/mM	1274:1281	1.788/mM	1274:1281	The sensitivity of the system towards copper (Cu) concentration was found as 1.788/mM for β-CD/AuNPs and 1.333/mM for AuNPs.
34224705	9	51	theme	system	1220:1225	arg1	sensitivity					1201:1211	The sensitivity	1197:1211	The sensitivity of the system towards copper (Cu) concentration	1197:1259	The sensitivity of the system towards copper (Cu) concentration was found as 1.788/mM for β-CD/AuNPs and 1.333/mM for AuNPs.
34224705	9	51	theme	system	1220:1225	arg1	1.333/mM					1302:1309	1.333/mM	1302:1309	1.333/mM	1302:1309	The sensitivity of the system towards copper (Cu) concentration was found as 1.788/mM for β-CD/AuNPs and 1.333/mM for AuNPs.
34224705	11	52	theme	waste	1495:1499	arg1	water					1501:1505	textile dyeing waste water	1480:1505	textile dyeing waste water in presence of AuNPs	1480:1526	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and β-CD/AuNPs was 0.005/min.
34224705	5	53	theme	characteristics	690:704	arg1	one					670:672	one	670:672	one	670:672	This sustains the enhancement in surface area (SA) to volume (V) ratio that is one of the peculiar characteristics of nanoparticles.
34224705	5	53	theme	characteristics	690:704	arg1	characteristics					690:704	the peculiar characteristics	677:704	the peculiar characteristics of nanoparticles	677:721	This sustains the enhancement in surface area (SA) to volume (V) ratio that is one of the peculiar characteristics of nanoparticles.
34224705	8	54	from	metals	1180:1185	arg1	water					1190:1194	water	1190:1194	water	1190:1194	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	7	55	from	decrease	819:826	arg1	distribution					866:877	improved distribution	857:877	improved distribution	857:877	Also it shows a decrease in average particle size and improved distribution.
34224705	7	55	from	decrease	819:826	arg1	size					848:851	average particle size	831:851	average particle size	831:851	Also it shows a decrease in average particle size and improved distribution.
34224705	2	56	theme	optical	335:341	arg1	studies					374:380	The structural, morphological, optical, compositional and vibrational studies	304:380	The structural, morphological, optical, compositional and vibrational studies for the AuNPs and β-CD/AuNPs	304:409	The structural, morphological, optical, compositional and vibrational studies for the AuNPs and β-CD/AuNPs were carried out.
34224705	9	57	theme	copper	1235:1240	arg1	concentration					1247:1259	copper (Cu) concentration	1235:1259	copper (Cu) concentration	1235:1259	The sensitivity of the system towards copper (Cu) concentration was found as 1.788/mM for β-CD/AuNPs and 1.333/mM for AuNPs.
34224705	10	58	theme	obtained	1355:1362	arg1	nanoparticles					1364:1376	the obtained nanoparticles	1351:1376	the obtained nanoparticles	1351:1376	The photocatalytic action of the obtained nanoparticles increases with decreasing average particle size.
34224705	8	59	dep	revealed	926:933	arg1	create					944:949	create	944:949	are revealed not only create uniform small sized nanoparticles	922:983	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	0	60	theme	dye	154:156	arg1	probe					63:67	a probe	61:67	a probe for the detection of heavy metals in water	61:110	Functionalization of gold nanoparticles by β-cyclodextrin as a probe for the detection of heavy metals in water and photocatalytic degradation of textile dye.
34224705	0	60	theme	dye	154:156	arg1	degradation					131:141	photocatalytic degradation	116:141	photocatalytic degradation of textile dye	116:156	Functionalization of gold nanoparticles by β-cyclodextrin as a probe for the detection of heavy metals in water and photocatalytic degradation of textile dye.
34224705	6	61	theme	TEM	724:726	arg1	results					728:734	TEM results	724:734	TEM results	724:734	TEM results show that β-CD/AuNPs formed were monodispersed and self assembled.
34224705	3	62	theme	FT-IR	483:487	arg1	results					489:495	FT-IR results	483:495	FT-IR results	483:495	Functionalization of AuNPs by β-CD was confirmed with FT-IR results.
34224705	11	63	theme	photocatalytic	1450:1463	arg1	degradation					1465:1475	this photocatalytic degradation	1445:1475	this photocatalytic degradation of textile dyeing waste water in presence of AuNPs	1445:1526	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and β-CD/AuNPs was 0.005/min.
34224705	11	64	from	degradation	1465:1475	arg1	presence					1510:1517	presence	1510:1517	presence of AuNPs	1510:1526	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and β-CD/AuNPs was 0.005/min.
34224705	9	65	theme	Cu	1243:1244	arg1	concentration					1247:1259	copper (Cu) concentration	1235:1259	copper (Cu) concentration	1235:1259	The sensitivity of the system towards copper (Cu) concentration was found as 1.788/mM for β-CD/AuNPs and 1.333/mM for AuNPs.
34224705	8	66	from	use	884:886	arg1	synthesis					903:911	the synthesis	899:911	the synthesis of AuNPs	899:920	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	8	67	theme	AuNPs	916:920	arg1	synthesis					903:911	the synthesis	899:911	the synthesis of AuNPs	899:920	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	11	68	from	presence	1510:1517	arg1	degradation					1465:1475	this photocatalytic degradation	1445:1475	this photocatalytic degradation of textile dyeing waste water in presence of AuNPs	1445:1526	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and β-CD/AuNPs was 0.005/min.
34224705	11	69	theme	degradation	1465:1475	arg1	value					1436:1440	The kapp value	1427:1440	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs	1427:1526	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and β-CD/AuNPs was 0.005/min.
34224705	11	69	theme	degradation	1465:1475	arg1	0.002/min					1532:1540	0.002/min	1532:1540	0.002/min	1532:1540	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and β-CD/AuNPs was 0.005/min.
34224705	8	70	from	concentration	1157:1169	arg1	water					1190:1194	water	1190:1194	water	1190:1194	The use of β-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water.
34224705	4	71	theme	UV-visible	502:511	arg1	spectra					524:530	The UV-visible absorption spectra	498:530	The UV-visible absorption spectra	498:530	The UV-visible absorption spectra exhibit a red-shift with decreasing average particle size.
34224705	2	72	dep	AuNPs	390:394	arg1	the					386:388	the	386:388	the	386:388	The structural, morphological, optical, compositional and vibrational studies for the AuNPs and β-CD/AuNPs were carried out.
34224705	2	73	theme	vibrational	362:372	arg1	studies					374:380	The structural, morphological, optical, compositional and vibrational studies	304:380	The structural, morphological, optical, compositional and vibrational studies for the AuNPs and β-CD/AuNPs	304:409	The structural, morphological, optical, compositional and vibrational studies for the AuNPs and β-CD/AuNPs were carried out.
34224705	11	74	theme	water	1501:1505	arg1	degradation					1465:1475	this photocatalytic degradation	1445:1475	this photocatalytic degradation of textile dyeing waste water in presence of AuNPs	1445:1526	The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and β-CD/AuNPs was 0.005/min.
33774399	7	0	theme	roughness	1099:1107	arg1	coefficient					1026:1036	the coefficient	1022:1036	the coefficient of friction (COF), friction energy dissipation and cartilage roughness	1022:1107	Measurements of the coefficient of friction (COF), friction energy dissipation and cartilage roughness indicated that cartilage was effectively protected by the high lubrication of HADN-Glu.
33774399	5	1	theme	zwitterionic	731:742	arg1	glutathione					760:770	zwitterionic peptide-reduced glutathione	731:770	zwitterionic peptide-reduced glutathione	731:770	Then, zwitterionic peptide-reduced glutathione was bioconjugated to HADN, forming a lubrication film.
33774399	8	2	theme	boundary	1276:1283	arg1	lubrication					1285:1295	the enhanced boundary lubrication	1263:1295	the enhanced boundary lubrication enabled by HADN-Glu on the PCU surface	1263:1334	Both at low and high applied loads, this effect was likely due to the enhanced boundary lubrication enabled by HADN-Glu on the PCU surface.
33774399	4	3	theme	PCU	680:682	arg1	surface					684:690	PCU surface	680:690	PCU surface	680:690	HADN was synthesized by carbodiimide chemistry between hyaluronic acid and dopamine and deposited on PCU surface under mild oxidative conditions.
33774399	9	4	theme	chondrocyte	1385:1395	arg1	cells					1397:1401	chondrocyte cells	1385:1401	chondrocyte cells	1385:1401	Moreover, HADN-Glu is highly biocompatible with chondrocyte cells, suggesting that this film will benefit the design of implants where lubrication is needed.
33774399	7	5	theme	HADN-Glu	1187:1194	arg1	lubrication					1172:1182	the high lubrication	1163:1182	the high lubrication of HADN-Glu	1163:1194	Measurements of the coefficient of friction (COF), friction energy dissipation and cartilage roughness indicated that cartilage was effectively protected by the high lubrication of HADN-Glu.
33774399	1	6	theme	PCU	170:172	arg1	implants					186:193	polycarbonate urethane (PCU) knee joint implants	146:193	polycarbonate urethane (PCU) knee joint implants	146:193	Biomaterials that are used in biological systems, such as polycarbonate urethane (PCU) knee joint implants and contact lenses, generally lack lubrication.
33774399	6	7	theme	force	892:896	arg1	AFM					910:912	AFM	910:912	AFM	910:912	Analysis based on X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and wettability indicated that HADN and Glu had grafted successfully onto the PCU surface.
33774399	6	7	theme	force	892:896	arg1	microscopy					898:907	atomic force microscopy	885:907	atomic force microscopy (AFM)	885:913	Analysis based on X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and wettability indicated that HADN and Glu had grafted successfully onto the PCU surface.
33774399	7	8	theme	cartilage	1089:1097	arg1	roughness					1099:1107	cartilage roughness	1089:1107	cartilage roughness	1089:1107	Measurements of the coefficient of friction (COF), friction energy dissipation and cartilage roughness indicated that cartilage was effectively protected by the high lubrication of HADN-Glu.
33774399	4	9	theme	oxidative	703:711	arg1	conditions					713:722	mild oxidative conditions	698:722	mild oxidative conditions	698:722	HADN was synthesized by carbodiimide chemistry between hyaluronic acid and dopamine and deposited on PCU surface under mild oxidative conditions.
33774399	6	10	theme	atomic	885:890	arg1	AFM					910:912	AFM	910:912	AFM	910:912	Analysis based on X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and wettability indicated that HADN and Glu had grafted successfully onto the PCU surface.
33774399	6	10	theme	atomic	885:890	arg1	microscopy					898:907	atomic force microscopy	885:907	atomic force microscopy (AFM)	885:913	Analysis based on X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and wettability indicated that HADN and Glu had grafted successfully onto the PCU surface.
33774399	7	11	theme	energy	1066:1071	arg1	dissipation					1073:1083	friction energy dissipation	1057:1083	friction energy dissipation	1057:1083	Measurements of the coefficient of friction (COF), friction energy dissipation and cartilage roughness indicated that cartilage was effectively protected by the high lubrication of HADN-Glu.
33774399	4	12	theme	carbodiimide	603:614	arg1	chemistry					616:624	carbodiimide chemistry	603:624	carbodiimide chemistry	603:624	HADN was synthesized by carbodiimide chemistry between hyaluronic acid and dopamine and deposited on PCU surface under mild oxidative conditions.
33774399	8	13	theme	PCU	1324:1326	arg1	surface					1328:1334	the PCU surface	1320:1334	the PCU surface	1320:1334	Both at low and high applied loads, this effect was likely due to the enhanced boundary lubrication enabled by HADN-Glu on the PCU surface.
33774399	8	14	theme	applied	1218:1224	arg1	loads					1226:1230	low and high applied loads	1205:1230	low and high applied loads	1205:1230	Both at low and high applied loads, this effect was likely due to the enhanced boundary lubrication enabled by HADN-Glu on the PCU surface.
33774399	3	15	theme	nanostructured	334:347	arg1	film					349:352	a nanostructured film	332:352	a nanostructured film	332:352	Here, we propose a nanostructured film based on hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu), which forms a composite coating (HADN-Glu) to enhance the lubrication between cartilage and PCU.
33774399	7	16	theme	dissipation	1073:1083	arg1	coefficient					1026:1036	the coefficient	1022:1036	the coefficient of friction (COF), friction energy dissipation and cartilage roughness	1022:1107	Measurements of the coefficient of friction (COF), friction energy dissipation and cartilage roughness indicated that cartilage was effectively protected by the high lubrication of HADN-Glu.
33774399	0	17	theme	Cartilage	0:8	arg1	splendens					17:25	Cartilage lamina splendens	0:25	Cartilage lamina splendens	0:25	Cartilage lamina splendens inspired nanostructured coating for biomaterial lubrication.
33774399	1	18	theme	knee	175:178	arg1	implants					186:193	polycarbonate urethane (PCU) knee joint implants	146:193	polycarbonate urethane (PCU) knee joint implants	146:193	Biomaterials that are used in biological systems, such as polycarbonate urethane (PCU) knee joint implants and contact lenses, generally lack lubrication.
33774399	0	19	theme	lamina	10:15	arg1	splendens					17:25	Cartilage lamina splendens	0:25	Cartilage lamina splendens	0:25	Cartilage lamina splendens inspired nanostructured coating for biomaterial lubrication.
33774399	1	20	theme	joint	180:184	arg1	implants					186:193	polycarbonate urethane (PCU) knee joint implants	146:193	polycarbonate urethane (PCU) knee joint implants	146:193	Biomaterials that are used in biological systems, such as polycarbonate urethane (PCU) knee joint implants and contact lenses, generally lack lubrication.
33774399	3	21	theme	hyaluronic	390:399	arg1	acid					401:404	hydrophilic polysaccharide hyaluronic acid	363:404	hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu)	363:479	Here, we propose a nanostructured film based on hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu), which forms a composite coating (HADN-Glu) to enhance the lubrication between cartilage and PCU.
33774399	7	22	theme	friction	1057:1064	arg1	dissipation					1073:1083	friction energy dissipation	1057:1083	friction energy dissipation	1057:1083	Measurements of the coefficient of friction (COF), friction energy dissipation and cartilage roughness indicated that cartilage was effectively protected by the high lubrication of HADN-Glu.
33774399	8	23	dep	loads	1226:1230	arg1	Both					1197:1200	Both	1197:1200	Both	1197:1200	Both at low and high applied loads, this effect was likely due to the enhanced boundary lubrication enabled by HADN-Glu on the PCU surface.
33774399	5	24	theme	lubrication	809:819	arg1	film					821:824	a lubrication film	807:824	a lubrication film	807:824	Then, zwitterionic peptide-reduced glutathione was bioconjugated to HADN, forming a lubrication film.
33774399	3	25	theme	hydrophilic	363:373	arg1	acid					401:404	hydrophilic polysaccharide hyaluronic acid	363:404	hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu)	363:479	Here, we propose a nanostructured film based on hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu), which forms a composite coating (HADN-Glu) to enhance the lubrication between cartilage and PCU.
33774399	1	26	theme	biological	118:127	arg1	systems					129:135	biological systems	118:135	biological systems	118:135	Biomaterials that are used in biological systems, such as polycarbonate urethane (PCU) knee joint implants and contact lenses, generally lack lubrication.
33774399	1	26	theme	biological	118:127	arg1	implants					186:193	polycarbonate urethane (PCU) knee joint implants	146:193	polycarbonate urethane (PCU) knee joint implants	146:193	Biomaterials that are used in biological systems, such as polycarbonate urethane (PCU) knee joint implants and contact lenses, generally lack lubrication.
33774399	1	26	theme	biological	118:127	arg1	lenses					207:212	contact lenses	199:212	contact lenses	199:212	Biomaterials that are used in biological systems, such as polycarbonate urethane (PCU) knee joint implants and contact lenses, generally lack lubrication.
33774399	1	27	theme	contact	199:205	arg1	lenses					207:212	contact lenses	199:212	contact lenses	199:212	Biomaterials that are used in biological systems, such as polycarbonate urethane (PCU) knee joint implants and contact lenses, generally lack lubrication.
33774399	7	28	theme	friction	1041:1048	arg1	coefficient					1026:1036	the coefficient	1022:1036	the coefficient of friction (COF), friction energy dissipation and cartilage roughness	1022:1107	Measurements of the coefficient of friction (COF), friction energy dissipation and cartilage roughness indicated that cartilage was effectively protected by the high lubrication of HADN-Glu.
33774399	4	29	theme	hyaluronic	634:643	arg1	acid					645:648	hyaluronic acid	634:648	hyaluronic acid	634:648	HADN was synthesized by carbodiimide chemistry between hyaluronic acid and dopamine and deposited on PCU surface under mild oxidative conditions.
33774399	3	30	theme	zwitterionic	442:453	arg1	Glu					476:478	Glu	476:478	Glu	476:478	Here, we propose a nanostructured film based on hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu), which forms a composite coating (HADN-Glu) to enhance the lubrication between cartilage and PCU.
33774399	3	30	theme	zwitterionic	442:453	arg1	glutathione					463:473	zwitterionic reduced glutathione	442:473	zwitterionic reduced glutathione (Glu)	442:479	Here, we propose a nanostructured film based on hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu), which forms a composite coating (HADN-Glu) to enhance the lubrication between cartilage and PCU.
33774399	0	31	theme	nanostructured	36:49	arg1	coating					51:57	nanostructured coating	36:57	nanostructured coating for biomaterial lubrication	36:85	Cartilage lamina splendens inspired nanostructured coating for biomaterial lubrication.
33774399	3	32	theme	reduced	455:461	arg1	Glu					476:478	Glu	476:478	Glu	476:478	Here, we propose a nanostructured film based on hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu), which forms a composite coating (HADN-Glu) to enhance the lubrication between cartilage and PCU.
33774399	3	32	theme	reduced	455:461	arg1	glutathione					463:473	zwitterionic reduced glutathione	442:473	zwitterionic reduced glutathione (Glu)	442:479	Here, we propose a nanostructured film based on hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu), which forms a composite coating (HADN-Glu) to enhance the lubrication between cartilage and PCU.
33774399	0	33	theme	biomaterial	63:73	arg1	lubrication					75:85	biomaterial lubrication	63:85	biomaterial lubrication	63:85	Cartilage lamina splendens inspired nanostructured coating for biomaterial lubrication.
33774399	7	34	theme	coefficient	1026:1036	arg1	Measurements					1006:1017	Measurements	1006:1017	Measurements of the coefficient of friction (COF), friction energy dissipation and cartilage roughness	1006:1107	Measurements of the coefficient of friction (COF), friction energy dissipation and cartilage roughness indicated that cartilage was effectively protected by the high lubrication of HADN-Glu.
33774399	6	35	theme	photoelectron	851:863	arg1	spectroscopy					865:876	X-ray photoelectron spectroscopy	845:876	X-ray photoelectron spectroscopy (XPS)	845:882	Analysis based on X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and wettability indicated that HADN and Glu had grafted successfully onto the PCU surface.
33774399	6	35	theme	photoelectron	851:863	arg1	XPS					879:881	XPS	879:881	XPS	879:881	Analysis based on X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and wettability indicated that HADN and Glu had grafted successfully onto the PCU surface.
33774399	8	36	from	loads	1226:1230	arg1	due					1256:1258	due	1256:1258	due	1256:1258	Both at low and high applied loads, this effect was likely due to the enhanced boundary lubrication enabled by HADN-Glu on the PCU surface.
33774399	4	37	theme	mild	698:701	arg1	conditions					713:722	mild oxidative conditions	698:722	mild oxidative conditions	698:722	HADN was synthesized by carbodiimide chemistry between hyaluronic acid and dopamine and deposited on PCU surface under mild oxidative conditions.
33774399	8	38	theme	low	1205:1207	arg1	loads					1226:1230	low and high applied loads	1205:1230	low and high applied loads	1205:1230	Both at low and high applied loads, this effect was likely due to the enhanced boundary lubrication enabled by HADN-Glu on the PCU surface.
33774399	2	39	with	integration	261:271	arg1	body					282:285	the body	278:285	the body	278:285	This limits their integration with the body and impedes their function.
33774399	6	40	theme	X-ray	845:849	arg1	spectroscopy					865:876	X-ray photoelectron spectroscopy	845:876	X-ray photoelectron spectroscopy (XPS)	845:882	Analysis based on X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and wettability indicated that HADN and Glu had grafted successfully onto the PCU surface.
33774399	6	40	theme	X-ray	845:849	arg1	XPS					879:881	XPS	879:881	XPS	879:881	Analysis based on X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and wettability indicated that HADN and Glu had grafted successfully onto the PCU surface.
33774399	9	41	theme	implants	1457:1464	arg1	design					1447:1452	the design	1443:1452	the design of implants	1443:1464	Moreover, HADN-Glu is highly biocompatible with chondrocyte cells, suggesting that this film will benefit the design of implants where lubrication is needed.
33774399	1	42	theme	polycarbonate	146:158	arg1	implants					186:193	polycarbonate urethane (PCU) knee joint implants	146:193	polycarbonate urethane (PCU) knee joint implants	146:193	Biomaterials that are used in biological systems, such as polycarbonate urethane (PCU) knee joint implants and contact lenses, generally lack lubrication.
33774399	1	43	used	used	110:113	arg2	Biomaterials					88:99	Biomaterials	88:99	Biomaterials that are used in biological systems, such as polycarbonate urethane (PCU) knee joint implants and contact lenses, generally	88:223	Biomaterials that are used in biological systems, such as polycarbonate urethane (PCU) knee joint implants and contact lenses, generally lack lubrication.
33774399	1	44	theme	urethane	160:167	arg1	implants					186:193	polycarbonate urethane (PCU) knee joint implants	146:193	polycarbonate urethane (PCU) knee joint implants	146:193	Biomaterials that are used in biological systems, such as polycarbonate urethane (PCU) knee joint implants and contact lenses, generally lack lubrication.
33774399	8	45	theme	enhanced	1267:1274	arg1	lubrication					1285:1295	the enhanced boundary lubrication	1263:1295	the enhanced boundary lubrication enabled by HADN-Glu on the PCU surface	1263:1334	Both at low and high applied loads, this effect was likely due to the enhanced boundary lubrication enabled by HADN-Glu on the PCU surface.
33774399	5	46	theme	peptide-reduced	744:758	arg1	glutathione					760:770	zwitterionic peptide-reduced glutathione	731:770	zwitterionic peptide-reduced glutathione	731:770	Then, zwitterionic peptide-reduced glutathione was bioconjugated to HADN, forming a lubrication film.
33774399	9	47	with	biocompatible	1366:1378	arg1	cells					1397:1401	chondrocyte cells	1385:1401	chondrocyte cells	1385:1401	Moreover, HADN-Glu is highly biocompatible with chondrocyte cells, suggesting that this film will benefit the design of implants where lubrication is needed.
33774399	3	48	theme	composite	496:504	arg1	HADN-Glu					515:522	HADN-Glu	515:522	HADN-Glu	515:522	Here, we propose a nanostructured film based on hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu), which forms a composite coating (HADN-Glu) to enhance the lubrication between cartilage and PCU.
33774399	3	48	theme	composite	496:504	arg1	coating					506:512	a composite coating	494:512	a composite coating (HADN-Glu) to enhance the lubrication between cartilage and PCU	494:576	Here, we propose a nanostructured film based on hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu), which forms a composite coating (HADN-Glu) to enhance the lubrication between cartilage and PCU.
33774399	8	49	theme	high	1213:1216	arg1	loads					1226:1230	low and high applied loads	1205:1230	low and high applied loads	1205:1230	Both at low and high applied loads, this effect was likely due to the enhanced boundary lubrication enabled by HADN-Glu on the PCU surface.
33774399	3	50	theme	polysaccharide	375:388	arg1	acid					401:404	hydrophilic polysaccharide hyaluronic acid	363:404	hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu)	363:479	Here, we propose a nanostructured film based on hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu), which forms a composite coating (HADN-Glu) to enhance the lubrication between cartilage and PCU.
33774399	7	51	theme	high	1167:1170	arg1	lubrication					1172:1182	the high lubrication	1163:1182	the high lubrication of HADN-Glu	1163:1194	Measurements of the coefficient of friction (COF), friction energy dissipation and cartilage roughness indicated that cartilage was effectively protected by the high lubrication of HADN-Glu.
33774399	6	52	theme	PCU	993:995	arg1	surface					997:1003	the PCU surface	989:1003	the PCU surface	989:1003	Analysis based on X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and wettability indicated that HADN and Glu had grafted successfully onto the PCU surface.
33568042	0	0	theme	Medikus	78:84	arg1	Extract					92:98	Medikus Seeds Extract	78:98	Medikus Seeds Extract	78:98	Formulation, Characterisation and In vitro Cytotoxic Effect of Lens culinaris Medikus Seeds Extract Loaded Chitosan Microspheres.
33568042	10	1	theme	microspheres	1452:1463	arg1	response					1426:1433	The significant cytotoxic response	1400:1433	The significant cytotoxic response of the developed microspheres	1400:1463	CONCLUSION The significant cytotoxic response of the developed microspheres may be attributed due to its low particle size, high entrapment efficiency and prolonged drug release profile.
33568042	1	2	theme	present	151:157	arg1	study					159:163	present study	151:163	present study	151:163	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	1	3	theme	Medikus	252:258	arg1	ME					281:282	ME	281:282	ME	281:282	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	1	3	theme	Medikus	252:258	arg1	seeds					274:278	Lens culinaris Medikus (L.culinaris) seeds	237:278	Lens culinaris Medikus (L.culinaris) seeds (ME)	237:283	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	0	4	theme	culinaris	68:76	arg1	Characterisation					13:28	Characterisation	13:28	Characterisation	13:28	Formulation, Characterisation and In vitro Cytotoxic Effect of Lens culinaris Medikus Seeds Extract Loaded Chitosan Microspheres.
33568042	0	4	theme	culinaris	68:76	arg1	Formulation					0:10	Formulation	0:10	Formulation	0:10	Formulation, Characterisation and In vitro Cytotoxic Effect of Lens culinaris Medikus Seeds Extract Loaded Chitosan Microspheres.
33568042	0	4	theme	culinaris	68:76	arg1	Effect					53:58	In vitro Cytotoxic Effect	34:58	In vitro Cytotoxic Effect of Lens culinaris	34:76	Formulation, Characterisation and In vitro Cytotoxic Effect of Lens culinaris Medikus Seeds Extract Loaded Chitosan Microspheres.
33568042	10	5	theme	developed	1442:1450	arg1	microspheres					1452:1463	the developed microspheres	1438:1463	the developed microspheres	1438:1463	CONCLUSION The significant cytotoxic response of the developed microspheres may be attributed due to its low particle size, high entrapment efficiency and prolonged drug release profile.
33568042	6	6	theme	drug	823:826	arg1	efficiency					839:848	The drug entrapment efficiency	819:848	The drug entrapment efficiency	819:848	The drug entrapment efficiency and cumulative drug release was found 1.58±0.02% and 81.95±0.35%, respectively.
33568042	1	7	theme	study	159:163	arg1	aim					144:146	The aim	140:146	The aim of present study	140:163	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	10	8	dep	CONCLUSION	1389:1398	arg1	attributed					1472:1481	attributed	1472:1481	may be attributed due to its low particle size, high entrapment efficiency and prolonged drug release profile	1465:1573	CONCLUSION The significant cytotoxic response of the developed microspheres may be attributed due to its low particle size, high entrapment efficiency and prolonged drug release profile.
33568042	1	9	theme	lung	333:336	arg1	line					357:360	lung cancer (A549) cell line	333:360	lung cancer (A549) cell line	333:360	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	8	10	theme	formulation	1067:1077	arg1	effect					1043:1048	The cytotoxic effect	1029:1048	The cytotoxic effect of the optimised formulation	1029:1077	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	1	11	dep	OBJECTIVE	130:138	arg1	was					165:167	was	165:167	was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line	165:360	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	1	12	theme	L.culinaris	261:271	arg1	ME					281:282	ME	281:282	ME	281:282	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	1	12	theme	L.culinaris	261:271	arg1	seeds					274:278	Lens culinaris Medikus (L.culinaris) seeds	237:278	Lens culinaris Medikus (L.culinaris) seeds (ME)	237:283	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	0	13	theme	Seeds	86:90	arg1	Extract					92:98	Medikus Seeds Extract	78:98	Medikus Seeds Extract	78:98	Formulation, Characterisation and In vitro Cytotoxic Effect of Lens culinaris Medikus Seeds Extract Loaded Chitosan Microspheres.
33568042	1	14	theme	cancer	338:343	arg1	line					357:360	lung cancer (A549) cell line	333:360	lung cancer (A549) cell line	333:360	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	8	15	theme	optimised	1057:1065	arg1	formulation					1067:1077	the optimised formulation	1053:1077	the optimised formulation	1053:1077	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	3	16	theme	in	542:543	arg1	release					556:562	in vitro drug release	542:562	in vitro drug release	542:562	The prepared microspheres were evaluated for its physicochemical characterisation, in vitro drug release and anti-cancer potential in vitro.
33568042	0	17	theme	Chitosan	107:114	arg1	Microspheres					116:127	Chitosan Microspheres	107:127	Chitosan Microspheres	107:127	Formulation, Characterisation and In vitro Cytotoxic Effect of Lens culinaris Medikus Seeds Extract Loaded Chitosan Microspheres.
33568042	4	18	theme	drug	731:734	arg1	release					736:742	drug release	731:742	drug release	731:742	RESULTS L.culinaris loaded chitosan microspheres were prepared successfully with suitable particle size, entrapment efficiency and drug release.
33568042	8	19	dep	seeds	1163:1167	arg1	IC50					1170:1173	IC50	1170:1173	IC50: 22.56 μg/ml vs. 63.58 μg/ml	1170:1202	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	3	20	theme	physicochemical	508:522	arg1	characterisation					524:539	its physicochemical characterisation	504:539	its physicochemical characterisation	504:539	The prepared microspheres were evaluated for its physicochemical characterisation, in vitro drug release and anti-cancer potential in vitro.
33568042	8	21	theme	reference	1238:1246	arg1	drug					1248:1251	reference drug	1238:1251	reference drug	1238:1251	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	8	21	theme	reference	1238:1246	arg1	doxorubicin					1254:1264	doxorubicin	1254:1264	doxorubicin (22 μg/ml)	1254:1275	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	10	22	theme	release	1559:1565	arg1	profile					1567:1573	prolonged drug release profile	1544:1573	prolonged drug release profile	1544:1573	CONCLUSION The significant cytotoxic response of the developed microspheres may be attributed due to its low particle size, high entrapment efficiency and prolonged drug release profile.
33568042	1	23	theme	A549	346:349	arg1	line					357:360	lung cancer (A549) cell line	333:360	lung cancer (A549) cell line	333:360	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	8	24	dep	IC50	1170:1173	arg1	μg/ml					1198:1202	22.56 μg/ml vs. 63.58 μg/ml	1176:1202	IC50: 22.56 μg/ml vs. 63.58 μg/ml	1170:1202	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	7	25	theme	calorimetry	952:962	arg1	studies					964:970	Differential scanning calorimetry studies	930:970	Differential scanning calorimetry studies	930:970	Differential scanning calorimetry studies revealed no interaction between drugs and polymers used.
33568042	10	26	theme	drug	1554:1557	arg1	profile					1567:1573	prolonged drug release profile	1544:1573	prolonged drug release profile	1544:1573	CONCLUSION The significant cytotoxic response of the developed microspheres may be attributed due to its low particle size, high entrapment efficiency and prolonged drug release profile.
33568042	5	27	theme	μm	815:816	arg1	size					802:805	the particle size	789:805	the particle size of 2.08 μm	789:816	The developed ME were spherical shaped with the particle size of 2.08 μm.
33568042	9	28	theme	optimised	1318:1326	arg1	effective					1345:1353	effective	1345:1353	effective	1345:1353	These observations demonstrate that the optimised microspheres are effective against lung cancer (A549) cells.
33568042	9	28	theme	optimised	1318:1326	arg1	microspheres					1328:1339	the optimised microspheres	1314:1339	the optimised microspheres	1314:1339	These observations demonstrate that the optimised microspheres are effective against lung cancer (A549) cells.
33568042	8	29	dep	response	1102:1109	arg1	compared					1114:1121	compared	1114:1121	compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml)	1114:1275	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	10	30	theme	high	1513:1516	arg1	efficiency					1529:1538	high entrapment efficiency	1513:1538	high entrapment efficiency	1513:1538	CONCLUSION The significant cytotoxic response of the developed microspheres may be attributed due to its low particle size, high entrapment efficiency and prolonged drug release profile.
33568042	4	31	theme	particle	690:697	arg1	size					699:702	suitable particle size	681:702	suitable particle size	681:702	RESULTS L.culinaris loaded chitosan microspheres were prepared successfully with suitable particle size, entrapment efficiency and drug release.
33568042	1	32	theme	seeds	274:278	arg1	extract					226:232	ethanolic extract	216:232	ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME)	216:283	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	6	33	theme	entrapment	828:837	arg1	efficiency					839:848	The drug entrapment efficiency	819:848	The drug entrapment efficiency	819:848	The drug entrapment efficiency and cumulative drug release was found 1.58±0.02% and 81.95±0.35%, respectively.
33568042	7	34	theme	Differential	930:941	arg1	studies					964:970	Differential scanning calorimetry studies	930:970	Differential scanning calorimetry studies	930:970	Differential scanning calorimetry studies revealed no interaction between drugs and polymers used.
33568042	6	35	theme	cumulative	854:863	arg1	release					870:876	cumulative drug release	854:876	cumulative drug release	854:876	The drug entrapment efficiency and cumulative drug release was found 1.58±0.02% and 81.95±0.35%, respectively.
33568042	1	36	theme	chitosan	182:189	arg1	microspheres					191:202	chitosan microspheres	182:202	chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME)	182:283	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	10	37	theme	significant	1404:1414	arg1	response					1426:1433	The significant cytotoxic response	1400:1433	The significant cytotoxic response of the developed microspheres	1400:1463	CONCLUSION The significant cytotoxic response of the developed microspheres may be attributed due to its low particle size, high entrapment efficiency and prolonged drug release profile.
33568042	10	38	theme	particle	1498:1505	arg1	size					1507:1510	its low particle size	1490:1510	its low particle size	1490:1510	CONCLUSION The significant cytotoxic response of the developed microspheres may be attributed due to its low particle size, high entrapment efficiency and prolonged drug release profile.
33568042	7	39	theme	scanning	943:950	arg1	studies					964:970	Differential scanning calorimetry studies	930:970	Differential scanning calorimetry studies	930:970	Differential scanning calorimetry studies revealed no interaction between drugs and polymers used.
33568042	9	40	theme	A549	1376:1379	arg1	cells					1382:1386	lung cancer (A549) cells	1363:1386	lung cancer (A549) cells	1363:1386	These observations demonstrate that the optimised microspheres are effective against lung cancer (A549) cells.
33568042	10	41	theme	low	1494:1496	arg1	size					1507:1510	its low particle size	1490:1510	its low particle size	1490:1510	CONCLUSION The significant cytotoxic response of the developed microspheres may be attributed due to its low particle size, high entrapment efficiency and prolonged drug release profile.
33568042	1	42	theme	cell	352:355	arg1	line					357:360	lung cancer (A549) cell line	333:360	lung cancer (A549) cell line	333:360	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	3	43	theme	drug	551:554	arg1	release					556:562	in vitro drug release	542:562	in vitro drug release	542:562	The prepared microspheres were evaluated for its physicochemical characterisation, in vitro drug release and anti-cancer potential in vitro.
33568042	4	44	theme	chitosan	627:634	arg1	microspheres					636:647	L.culinaris loaded chitosan microspheres	608:647	L.culinaris loaded chitosan microspheres	608:647	RESULTS L.culinaris loaded chitosan microspheres were prepared successfully with suitable particle size, entrapment efficiency and drug release.
33568042	5	45	theme	particle	793:800	arg1	size					802:805	the particle size	789:805	the particle size of 2.08 μm	789:816	The developed ME were spherical shaped with the particle size of 2.08 μm.
33568042	4	46	theme	suitable	681:688	arg1	size					699:702	suitable particle size	681:702	suitable particle size	681:702	RESULTS L.culinaris loaded chitosan microspheres were prepared successfully with suitable particle size, entrapment efficiency and drug release.
33568042	2	47	theme	composite	379:387	arg1	design					389:394	Central composite design	371:394	Central composite design	371:394	METHODS Central composite design was applied to prepare and optimise the chitosan microspheres.
33568042	0	48	theme	In	34:35	arg1	Effect					53:58	In vitro Cytotoxic Effect	34:58	In vitro Cytotoxic Effect of Lens culinaris	34:76	Formulation, Characterisation and In vitro Cytotoxic Effect of Lens culinaris Medikus Seeds Extract Loaded Chitosan Microspheres.
33568042	9	49	theme	lung	1363:1366	arg1	cells					1382:1386	lung cancer (A549) cells	1363:1386	lung cancer (A549) cells	1363:1386	These observations demonstrate that the optimised microspheres are effective against lung cancer (A549) cells.
33568042	2	50	theme	chitosan	436:443	arg1	microspheres					445:456	the chitosan microspheres	432:456	the chitosan microspheres	432:456	METHODS Central composite design was applied to prepare and optimise the chitosan microspheres.
33568042	5	51	theme	developed	749:757	arg1	ME					759:760	The developed ME	745:760	The developed ME	745:760	The developed ME were spherical shaped with the particle size of 2.08 μm.
33568042	5	51	theme	developed	749:757	arg1	shaped					777:782	shaped	777:782	shaped	777:782	The developed ME were spherical shaped with the particle size of 2.08 μm.
33568042	8	52	theme	cytotoxic	1033:1041	arg1	effect					1043:1048	The cytotoxic effect	1029:1048	The cytotoxic effect of the optimised formulation	1029:1077	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	1	53	theme	ethanolic	216:224	arg1	extract					226:232	ethanolic extract	216:232	ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME)	216:283	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	10	54	theme	cytotoxic	1416:1424	arg1	response					1426:1433	The significant cytotoxic response	1400:1433	The significant cytotoxic response of the developed microspheres	1400:1463	CONCLUSION The significant cytotoxic response of the developed microspheres may be attributed due to its low particle size, high entrapment efficiency and prolonged drug release profile.
33568042	9	55	theme	cancer	1368:1373	arg1	cells					1382:1386	lung cancer (A549) cells	1363:1386	lung cancer (A549) cells	1363:1386	These observations demonstrate that the optimised microspheres are effective against lung cancer (A549) cells.
33568042	10	56	theme	entrapment	1518:1527	arg1	efficiency					1529:1538	high entrapment efficiency	1513:1538	high entrapment efficiency	1513:1538	CONCLUSION The significant cytotoxic response of the developed microspheres may be attributed due to its low particle size, high entrapment efficiency and prolonged drug release profile.
33568042	6	57	theme	drug	865:868	arg1	release					870:876	cumulative drug release	854:876	cumulative drug release	854:876	The drug entrapment efficiency and cumulative drug release was found 1.58±0.02% and 81.95±0.35%, respectively.
33568042	3	58	theme	anti-cancer	568:578	arg1	potential					580:588	anti-cancer potential	568:588	anti-cancer potential	568:588	The prepared microspheres were evaluated for its physicochemical characterisation, in vitro drug release and anti-cancer potential in vitro.
33568042	3	59	theme	prepared	463:470	arg1	microspheres					472:483	The prepared microspheres	459:483	The prepared microspheres	459:483	The prepared microspheres were evaluated for its physicochemical characterisation, in vitro drug release and anti-cancer potential in vitro.
33568042	0	60	theme	Cytotoxic	43:51	arg1	Effect					53:58	In vitro Cytotoxic Effect	34:58	In vitro Cytotoxic Effect of Lens culinaris	34:76	Formulation, Characterisation and In vitro Cytotoxic Effect of Lens culinaris Medikus Seeds Extract Loaded Chitosan Microspheres.
33568042	8	61	theme	ethanolic	1130:1138	arg1	extract					1140:1146	the ethanolic extract	1126:1146	the ethanolic extract	1126:1146	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	8	61	theme	ethanolic	1130:1138	arg1	comparable					1216:1225	comparable	1216:1225	comparable	1216:1225	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	4	62	dep	loaded	620:625	arg1	L.culinaris					608:618	L.culinaris	608:618	L.culinaris	608:618	RESULTS L.culinaris loaded chitosan microspheres were prepared successfully with suitable particle size, entrapment efficiency and drug release.
33568042	0	63	dep	In	34:35	arg1	vitro					37:41	vitro	37:41	vitro	37:41	Formulation, Characterisation and In vitro Cytotoxic Effect of Lens culinaris Medikus Seeds Extract Loaded Chitosan Microspheres.
33568042	5	64	with	shaped	777:782	arg1	size					802:805	the particle size	789:805	the particle size of 2.08 μm	789:816	The developed ME were spherical shaped with the particle size of 2.08 μm.
33568042	8	65	theme	L.culinaris	1151:1161	arg1	seeds					1163:1167	L.culinaris seeds	1151:1167	L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml)	1151:1203	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	4	66	theme	entrapment	705:714	arg1	efficiency					716:725	entrapment efficiency	705:725	entrapment efficiency	705:725	RESULTS L.culinaris loaded chitosan microspheres were prepared successfully with suitable particle size, entrapment efficiency and drug release.
33568042	10	67	theme	prolonged	1544:1552	arg1	profile					1567:1573	prolonged drug release profile	1544:1573	prolonged drug release profile	1544:1573	CONCLUSION The significant cytotoxic response of the developed microspheres may be attributed due to its low particle size, high entrapment efficiency and prolonged drug release profile.
33568042	4	68	dep	RESULTS	600:606	arg1	prepared					654:661	prepared	654:661	were prepared successfully with suitable particle size, entrapment efficiency and drug release	649:742	RESULTS L.culinaris loaded chitosan microspheres were prepared successfully with suitable particle size, entrapment efficiency and drug release.
33568042	3	69	dep	in	542:543	arg1	vitro					545:549	vitro	545:549	vitro	545:549	The prepared microspheres were evaluated for its physicochemical characterisation, in vitro drug release and anti-cancer potential in vitro.
33568042	8	70	theme	significant	1090:1100	arg1	response					1102:1109	a significant response	1088:1109	a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml)	1088:1275	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	2	71	theme	Central	371:377	arg1	design					389:394	Central composite design	371:394	Central composite design	371:394	METHODS Central composite design was applied to prepare and optimise the chitosan microspheres.
33568042	2	72	dep	METHODS	363:369	arg1	applied					400:406	applied	400:406	was applied to prepare and optimise the chitosan microspheres	396:456	METHODS Central composite design was applied to prepare and optimise the chitosan microspheres.
33568042	4	73	theme	loaded	620:625	arg1	microspheres					636:647	L.culinaris loaded chitosan microspheres	608:647	L.culinaris loaded chitosan microspheres	608:647	RESULTS L.culinaris loaded chitosan microspheres were prepared successfully with suitable particle size, entrapment efficiency and drug release.
33568042	8	74	theme	seeds	1163:1167	arg1	extract					1140:1146	the ethanolic extract	1126:1146	the ethanolic extract	1126:1146	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	8	74	theme	seeds	1163:1167	arg1	comparable					1216:1225	comparable	1216:1225	comparable	1216:1225	The cytotoxic effect of the optimised formulation revealed a significant response as compared to the ethanolic extract of L.culinaris seeds (IC50: 22.56 μg/ml vs. 63.58 μg/ml), which was comparable to that of reference drug, doxorubicin (22 μg/ml).
33568042	1	75	theme	anticancer	304:313	arg1	potential					315:323	its anticancer potential	300:323	its anticancer potential against lung cancer (A549) cell line	300:360	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	0	76	dep	Formulation	0:10	arg1	Extract					92:98	Medikus Seeds Extract	78:98	Medikus Seeds Extract	78:98	Formulation, Characterisation and In vitro Cytotoxic Effect of Lens culinaris Medikus Seeds Extract Loaded Chitosan Microspheres.
33568042	1	77	theme	culinaris	242:250	arg1	ME					281:282	ME	281:282	ME	281:282	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
33568042	1	77	theme	culinaris	242:250	arg1	seeds					274:278	Lens culinaris Medikus (L.culinaris) seeds	237:278	Lens culinaris Medikus (L.culinaris) seeds (ME)	237:283	OBJECTIVE The aim of present study was to formulate chitosan microspheres loaded with ethanolic extract of Lens culinaris Medikus (L.culinaris) seeds (ME) and to explore its anticancer potential against lung cancer (A549) cell line.
32589791	7	0	theme	freeze-casting	1204:1217	arg1	technique					1219:1227	freeze-casting technique	1204:1227	freeze-casting technique	1204:1227	The pore architecture of the scaffolds was altered using freeze-casting technique to make both large and small pores that were aligned or with a non-aligned random structure.
32589791	10	1	from	increase	1557:1564	arg1	expression					1585:1594	the fibronectin expression	1569:1594	the fibronectin expression with the incorporation of GAGs	1569:1625	There was an increase in the fibronectin expression with the incorporation of GAGs, and its morphology was changed by the underlying pore architecture.
32589791	5	2	contain	containing	834:843	arg2	glycosaminoglycans					855:872	different glycosaminoglycans	845:872	different glycosaminoglycans (GAGs)	845:879	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	5	2	contain	containing	834:843	arg2	GAGs					875:878	GAGs	875:878	GAGs	875:878	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	5	2	contain	containing	834:843	arg2	architectures					900:912	different pore architectures	885:912	different pore architectures	885:912	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	5	2	contain	containing	834:843	arg1	scaffolds					824:832	various collagen scaffolds	807:832	various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures	807:912	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	3	3	theme	tissue	477:482	arg1	limitations					484:494	donor tissue limitations	471:494	donor tissue limitations	471:494	The small size, donor tissue limitations, and high complexity of the TM make it difficult to research the relationship between the TM cells and their immediate environment.
32589791	9	4	theme	pore	1479:1482	arg1	scaffolds					1484:1492	large pore scaffolds	1473:1492	large pore scaffolds	1473:1492	It was found that the hTM cells grown on large pore scaffolds proliferate more than those grown on small pores.
32589791	0	5	theme	pore	75:78	arg1	architecture					80:91	collagen scaffold pore architecture	57:91	collagen scaffold pore architecture	57:91	Human trabecular meshwork cell behavior is influenced by collagen scaffold pore architecture and glycosaminoglycan composition.
32589791	11	6	from	changes	1783:1789	arg1	microenvironment					1800:1815	their microenvironment	1794:1815	their microenvironment	1794:1815	This work will help provide an insight into the behavior of hTM cells when introducing changes in their microenvironment.
32589791	6	7	theme	matrix	1118:1123	arg1	fibronectin					1134:1144	fibronectin	1134:1144	fibronectin	1134:1144	Cellular response was measured by quantifying cellular proliferation and expression of an important extracellular matrix protein, fibronectin.
32589791	6	7	theme	matrix	1118:1123	arg1	protein					1125:1131	an important extracellular matrix protein	1091:1131	an important extracellular matrix protein	1091:1131	Cellular response was measured by quantifying cellular proliferation and expression of an important extracellular matrix protein, fibronectin.
32589791	0	8	theme	glycosaminoglycan	97:113	arg1	composition					115:125	glycosaminoglycan composition	97:125	glycosaminoglycan composition	97:125	Human trabecular meshwork cell behavior is influenced by collagen scaffold pore architecture and glycosaminoglycan composition.
32589791	2	9	dep	humor	360:364	arg1	generation					366:375	generation	366:375	generation	366:375	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	8	10	theme	hyaluronic	1415:1424	arg1	acid					1426:1429	hyaluronic acid	1415:1429	hyaluronic acid	1415:1429	The composition of the scaffolds was altered with the addition of chondroitin sulfate and/or hyaluronic acid.
32589791	4	11	theme	development	732:742	arg1	platforms					744:752	in vitro drug development platforms	718:752	in vitro drug development platforms	718:752	Thus, a biomaterial-based approach may be more appropriate for research manipulations and in vitro drug development platforms.
32589791	9	12	theme	small	1531:1535	arg1	pores					1537:1541	small pores	1531:1541	small pores	1531:1541	It was found that the hTM cells grown on large pore scaffolds proliferate more than those grown on small pores.
32589791	10	13	theme	underlying	1666:1675	arg1	architecture					1682:1693	the underlying pore architecture	1662:1693	the underlying pore architecture	1662:1693	There was an increase in the fibronectin expression with the incorporation of GAGs, and its morphology was changed by the underlying pore architecture.
32589791	7	14	theme	large	1242:1246	arg1	pores					1258:1262	both large and small pores	1237:1262	both large and small pores that were aligned or with a non-aligned random structure	1237:1319	The pore architecture of the scaffolds was altered using freeze-casting technique to make both large and small pores that were aligned or with a non-aligned random structure.
32589791	4	15	theme	drug	727:730	arg1	platforms					744:752	in vitro drug development platforms	718:752	in vitro drug development platforms	718:752	Thus, a biomaterial-based approach may be more appropriate for research manipulations and in vitro drug development platforms.
32589791	5	16	from	changes	960:966	arg1	environment					991:1001	their extracellular environment	971:1001	their extracellular environment	971:1001	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	5	17	theme	different	885:893	arg1	architectures					900:912	different pore architectures	885:912	different pore architectures	885:912	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	7	18	theme	scaffolds	1176:1184	arg1	architecture					1156:1167	The pore architecture	1147:1167	The pore architecture of the scaffolds	1147:1184	The pore architecture of the scaffolds was altered using freeze-casting technique to make both large and small pores that were aligned or with a non-aligned random structure.
32589791	10	19	theme	pore	1677:1680	arg1	architecture					1682:1693	the underlying pore architecture	1662:1693	the underlying pore architecture	1662:1693	There was an increase in the fibronectin expression with the incorporation of GAGs, and its morphology was changed by the underlying pore architecture.
32589791	5	20	theme	human	769:773	arg1	TM					775:776	human TM	769:776	human TM (hTM) cells	769:788	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	5	20	theme	human	769:773	arg1	hTM					779:781	hTM	779:781	hTM	779:781	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	3	21	theme	high	501:504	arg1	complexity					506:515	high complexity	501:515	high complexity of the TM	501:525	The small size, donor tissue limitations, and high complexity of the TM make it difficult to research the relationship between the TM cells and their immediate environment.
32589791	7	22	theme	random	1304:1309	arg1	structure					1311:1319	a non-aligned random structure	1290:1319	a non-aligned random structure	1290:1319	The pore architecture of the scaffolds was altered using freeze-casting technique to make both large and small pores that were aligned or with a non-aligned random structure.
32589791	2	23	theme	subsequent	381:390	arg1	drainage					392:399	subsequent drainage	381:399	subsequent drainage	381:399	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	6	24	theme	extracellular	1104:1116	arg1	fibronectin					1134:1144	fibronectin	1134:1144	fibronectin	1134:1144	Cellular response was measured by quantifying cellular proliferation and expression of an important extracellular matrix protein, fibronectin.
32589791	6	24	theme	extracellular	1104:1116	arg1	protein					1125:1131	an important extracellular matrix protein	1091:1131	an important extracellular matrix protein	1091:1131	Cellular response was measured by quantifying cellular proliferation and expression of an important extracellular matrix protein, fibronectin.
32589791	7	25	theme	non-aligned	1292:1302	arg1	structure					1311:1319	a non-aligned random structure	1290:1319	a non-aligned random structure	1290:1319	The pore architecture of the scaffolds was altered using freeze-casting technique to make both large and small pores that were aligned or with a non-aligned random structure.
32589791	5	26	theme	TM	775:776	arg1	cells					784:788	human TM (hTM) cells	769:788	human TM (hTM) cells	769:788	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	5	27	theme	various	807:813	arg1	scaffolds					824:832	various collagen scaffolds	807:832	various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures	807:912	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	0	28	theme	trabecular	6:15	arg1	behavior					31:38	Human trabecular meshwork cell behavior	0:38	Human trabecular meshwork cell behavior	0:38	Human trabecular meshwork cell behavior is influenced by collagen scaffold pore architecture and glycosaminoglycan composition.
32589791	11	29	theme	hTM	1756:1758	arg1	cells					1760:1764	hTM cells	1756:1764	hTM cells	1756:1764	This work will help provide an insight into the behavior of hTM cells when introducing changes in their microenvironment.
32589791	7	30	theme	small	1252:1256	arg1	pores					1258:1262	both large and small pores	1237:1262	both large and small pores that were aligned or with a non-aligned random structure	1237:1319	The pore architecture of the scaffolds was altered using freeze-casting technique to make both large and small pores that were aligned or with a non-aligned random structure.
32589791	5	31	theme	pore	895:898	arg1	architectures					900:912	different pore architectures	885:912	different pore architectures	885:912	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	5	32	theme	collagen	815:822	arg1	scaffolds					824:832	various collagen scaffolds	807:832	various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures	807:912	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	0	33	theme	Human	0:4	arg1	behavior					31:38	Human trabecular meshwork cell behavior	0:38	Human trabecular meshwork cell behavior	0:38	Human trabecular meshwork cell behavior is influenced by collagen scaffold pore architecture and glycosaminoglycan composition.
32589791	11	34	theme	cells	1760:1764	arg1	behavior					1744:1751	the behavior	1740:1751	the behavior of hTM cells	1740:1764	This work will help provide an insight into the behavior of hTM cells when introducing changes in their microenvironment.
32589791	2	35	theme	intraocular	297:307	arg1	factor					261:266	The primary risk factor	244:266	The primary risk factor for glaucoma	244:279	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	2	35	theme	intraocular	297:307	arg1	pressure					309:316	an increased intraocular pressure	284:316	an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system	284:452	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	8	36	theme	scaffolds	1345:1353	arg1	composition					1326:1336	The composition	1322:1336	The composition of the scaffolds	1322:1353	The composition of the scaffolds was altered with the addition of chondroitin sulfate and/or hyaluronic acid.
32589791	2	37	theme	humor	360:364	arg1	imbalance					339:347	an imbalance	336:347	an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system	336:452	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	0	38	theme	cell	26:29	arg1	behavior					31:38	Human trabecular meshwork cell behavior	0:38	Human trabecular meshwork cell behavior	0:38	Human trabecular meshwork cell behavior is influenced by collagen scaffold pore architecture and glycosaminoglycan composition.
32589791	10	39	theme	fibronectin	1573:1583	arg1	expression					1585:1594	the fibronectin expression	1569:1594	the fibronectin expression with the incorporation of GAGs	1569:1625	There was an increase in the fibronectin expression with the incorporation of GAGs, and its morphology was changed by the underlying pore architecture.
32589791	8	40	theme	chondroitin	1388:1398	arg1	sulfate					1400:1406	chondroitin sulfate	1388:1406	chondroitin sulfate	1388:1406	The composition of the scaffolds was altered with the addition of chondroitin sulfate and/or hyaluronic acid.
32589791	2	41	theme	increased	287:295	arg1	factor					261:266	The primary risk factor	244:266	The primary risk factor for glaucoma	244:279	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	2	41	theme	increased	287:295	arg1	pressure					309:316	an increased intraocular pressure	284:316	an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system	284:452	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	2	42	theme	trabecular	413:422	arg1	TM					434:435	TM	434:435	TM	434:435	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	2	42	theme	trabecular	413:422	arg1	meshwork					424:431	trabecular meshwork	413:431	the trabecular meshwork (TM) drainage system	409:452	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	2	43	theme	meshwork	424:431	arg1	system					447:452	the trabecular meshwork (TM) drainage system	409:452	the trabecular meshwork (TM) drainage system	409:452	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	5	44	theme	hTM	939:941	arg1	cells					943:947	hTM cells	939:947	hTM cells	939:947	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	3	45	theme	immediate	605:613	arg1	environment					615:625	their immediate environment	599:625	their immediate environment	599:625	The small size, donor tissue limitations, and high complexity of the TM make it difficult to research the relationship between the TM cells and their immediate environment.
32589791	4	46	theme	in	718:719	arg1	platforms					744:752	in vitro drug development platforms	718:752	in vitro drug development platforms	718:752	Thus, a biomaterial-based approach may be more appropriate for research manipulations and in vitro drug development platforms.
32589791	1	47	theme	eye	155:157	arg1	disease					159:165	a degenerative eye disease	140:165	a degenerative eye disease in which damage to the optic nerve leads to a characteristic loss of vision	140:241	Glaucoma is a degenerative eye disease in which damage to the optic nerve leads to a characteristic loss of vision.
32589791	1	47	theme	eye	155:157	arg1	Glaucoma					128:135	Glaucoma	128:135	Glaucoma	128:135	Glaucoma is a degenerative eye disease in which damage to the optic nerve leads to a characteristic loss of vision.
32589791	4	48	dep	in	718:719	arg1	vitro					721:725	vitro	721:725	vitro	721:725	Thus, a biomaterial-based approach may be more appropriate for research manipulations and in vitro drug development platforms.
32589791	9	49	theme	large	1473:1477	arg1	scaffolds					1484:1492	large pore scaffolds	1473:1492	large pore scaffolds	1473:1492	It was found that the hTM cells grown on large pore scaffolds proliferate more than those grown on small pores.
32589791	1	50	theme	optic	190:194	arg1	nerve					196:200	the optic nerve	186:200	the optic nerve	186:200	Glaucoma is a degenerative eye disease in which damage to the optic nerve leads to a characteristic loss of vision.
32589791	5	51	theme	extracellular	977:989	arg1	environment					991:1001	their extracellular environment	971:1001	their extracellular environment	971:1001	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	2	52	theme	drainage	392:399	arg1	imbalance					339:347	an imbalance	336:347	an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system	336:452	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	6	53	theme	Cellular	1004:1011	arg1	response					1013:1020	Cellular response	1004:1020	Cellular response	1004:1020	Cellular response was measured by quantifying cellular proliferation and expression of an important extracellular matrix protein, fibronectin.
32589791	8	54	theme	sulfate	1400:1406	arg1	addition					1376:1383	the addition	1372:1383	the addition of chondroitin sulfate and/or hyaluronic acid	1372:1429	The composition of the scaffolds was altered with the addition of chondroitin sulfate and/or hyaluronic acid.
32589791	6	55	theme	protein	1125:1131	arg1	expression					1077:1086	expression	1077:1086	expression	1077:1086	Cellular response was measured by quantifying cellular proliferation and expression of an important extracellular matrix protein, fibronectin.
32589791	6	55	theme	protein	1125:1131	arg1	proliferation					1059:1071	proliferation	1059:1071	proliferation	1059:1071	Cellular response was measured by quantifying cellular proliferation and expression of an important extracellular matrix protein, fibronectin.
32589791	2	56	theme	drainage	438:445	arg1	system					447:452	the trabecular meshwork (TM) drainage system	409:452	the trabecular meshwork (TM) drainage system	409:452	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	8	57	theme	acid	1426:1429	arg1	addition					1376:1383	the addition	1372:1383	the addition of chondroitin sulfate and/or hyaluronic acid	1372:1429	The composition of the scaffolds was altered with the addition of chondroitin sulfate and/or hyaluronic acid.
32589791	9	58	theme	hTM	1454:1456	arg1	cells					1458:1462	the hTM cells	1450:1462	the hTM cells grown on large pore scaffolds	1450:1492	It was found that the hTM cells grown on large pore scaffolds proliferate more than those grown on small pores.
32589791	3	59	theme	donor	471:475	arg1	limitations					484:494	donor tissue limitations	471:494	donor tissue limitations	471:494	The small size, donor tissue limitations, and high complexity of the TM make it difficult to research the relationship between the TM cells and their immediate environment.
32589791	7	60	theme	pore	1151:1154	arg1	architecture					1156:1167	The pore architecture	1147:1167	The pore architecture of the scaffolds	1147:1184	The pore architecture of the scaffolds was altered using freeze-casting technique to make both large and small pores that were aligned or with a non-aligned random structure.
32589791	3	61	theme	TM	586:587	arg1	cells					589:593	the TM cells	582:593	the TM cells	582:593	The small size, donor tissue limitations, and high complexity of the TM make it difficult to research the relationship between the TM cells and their immediate environment.
32589791	2	62	theme	risk	256:259	arg1	factor					261:266	The primary risk factor	244:266	The primary risk factor for glaucoma	244:279	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	2	62	theme	risk	256:259	arg1	pressure					309:316	an increased intraocular pressure	284:316	an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system	284:452	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	3	63	theme	small	459:463	arg1	size					465:468	The small size	455:468	The small size	455:468	The small size, donor tissue limitations, and high complexity of the TM make it difficult to research the relationship between the TM cells and their immediate environment.
32589791	3	64	theme	TM	524:525	arg1	limitations					484:494	donor tissue limitations	471:494	donor tissue limitations	471:494	The small size, donor tissue limitations, and high complexity of the TM make it difficult to research the relationship between the TM cells and their immediate environment.
32589791	3	64	theme	TM	524:525	arg1	size					465:468	The small size	455:468	The small size	455:468	The small size, donor tissue limitations, and high complexity of the TM make it difficult to research the relationship between the TM cells and their immediate environment.
32589791	3	64	theme	TM	524:525	arg1	complexity					506:515	high complexity	501:515	high complexity of the TM	501:525	The small size, donor tissue limitations, and high complexity of the TM make it difficult to research the relationship between the TM cells and their immediate environment.
32589791	1	65	theme	characteristic	213:226	arg1	loss					228:231	a characteristic loss	211:231	a characteristic loss of vision	211:241	Glaucoma is a degenerative eye disease in which damage to the optic nerve leads to a characteristic loss of vision.
32589791	6	66	theme	important	1094:1102	arg1	fibronectin					1134:1144	fibronectin	1134:1144	fibronectin	1134:1144	Cellular response was measured by quantifying cellular proliferation and expression of an important extracellular matrix protein, fibronectin.
32589791	6	66	theme	important	1094:1102	arg1	protein					1125:1131	an important extracellular matrix protein	1091:1131	an important extracellular matrix protein	1091:1131	Cellular response was measured by quantifying cellular proliferation and expression of an important extracellular matrix protein, fibronectin.
32589791	10	67	theme	GAGs	1622:1625	arg1	incorporation					1605:1617	the incorporation	1601:1617	the incorporation of GAGs	1601:1625	There was an increase in the fibronectin expression with the incorporation of GAGs, and its morphology was changed by the underlying pore architecture.
32589791	2	68	theme	primary	248:254	arg1	factor					261:266	The primary risk factor	244:266	The primary risk factor for glaucoma	244:279	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	2	68	theme	primary	248:254	arg1	pressure					309:316	an increased intraocular pressure	284:316	an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system	284:452	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	1	69	theme	degenerative	142:153	arg1	disease					159:165	a degenerative eye disease	140:165	a degenerative eye disease in which damage to the optic nerve leads to a characteristic loss of vision	140:241	Glaucoma is a degenerative eye disease in which damage to the optic nerve leads to a characteristic loss of vision.
32589791	1	69	theme	degenerative	142:153	arg1	Glaucoma					128:135	Glaucoma	128:135	Glaucoma	128:135	Glaucoma is a degenerative eye disease in which damage to the optic nerve leads to a characteristic loss of vision.
32589791	4	70	theme	research	691:698	arg1	manipulations					700:712	research manipulations	691:712	research manipulations	691:712	Thus, a biomaterial-based approach may be more appropriate for research manipulations and in vitro drug development platforms.
32589791	0	71	theme	scaffold	66:73	arg1	architecture					80:91	collagen scaffold pore architecture	57:91	collagen scaffold pore architecture	57:91	Human trabecular meshwork cell behavior is influenced by collagen scaffold pore architecture and glycosaminoglycan composition.
32589791	5	72	theme	different	845:853	arg1	glycosaminoglycans					855:872	different glycosaminoglycans	845:872	different glycosaminoglycans (GAGs)	845:879	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	5	72	theme	different	845:853	arg1	GAGs					875:878	GAGs	875:878	GAGs	875:878	In this work, human TM (hTM) cells were cultured on various collagen scaffolds containing different glycosaminoglycans (GAGs) and different pore architectures to better understand how hTM cells respond to changes in their extracellular environment.
32589791	10	73	with	expression	1585:1594	arg1	incorporation					1605:1617	the incorporation	1601:1617	the incorporation of GAGs	1601:1625	There was an increase in the fibronectin expression with the incorporation of GAGs, and its morphology was changed by the underlying pore architecture.
32589791	2	74	theme	aqueous	352:358	arg1	humor					360:364	aqueous humor generation and subsequent drainage	352:399	humor	360:364	The primary risk factor for glaucoma is an increased intraocular pressure that is caused by an imbalance of aqueous humor generation and subsequent drainage through the trabecular meshwork (TM) drainage system.
32589791	6	75	theme	cellular	1050:1057	arg1	proliferation					1059:1071	proliferation	1059:1071	proliferation	1059:1071	Cellular response was measured by quantifying cellular proliferation and expression of an important extracellular matrix protein, fibronectin.
32589791	0	76	theme	collagen	57:64	arg1	architecture					80:91	collagen scaffold pore architecture	57:91	collagen scaffold pore architecture	57:91	Human trabecular meshwork cell behavior is influenced by collagen scaffold pore architecture and glycosaminoglycan composition.
32589791	0	77	theme	meshwork	17:24	arg1	behavior					31:38	Human trabecular meshwork cell behavior	0:38	Human trabecular meshwork cell behavior	0:38	Human trabecular meshwork cell behavior is influenced by collagen scaffold pore architecture and glycosaminoglycan composition.
32589791	4	78	theme	biomaterial-based	636:652	arg1	appropriate					675:685	appropriate	675:685	appropriate	675:685	Thus, a biomaterial-based approach may be more appropriate for research manipulations and in vitro drug development platforms.
32589791	4	78	theme	biomaterial-based	636:652	arg1	approach					654:661	a biomaterial-based approach	634:661	a biomaterial-based approach	634:661	Thus, a biomaterial-based approach may be more appropriate for research manipulations and in vitro drug development platforms.
32589791	1	79	theme	vision	236:241	arg1	loss					228:231	a characteristic loss	211:231	a characteristic loss of vision	211:241	Glaucoma is a degenerative eye disease in which damage to the optic nerve leads to a characteristic loss of vision.
33236499	6	0	theme	structure	824:832	arg1	Analyses					792:799	Analyses	792:799	Analyses of starch composition, structure and properties	792:847	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	7	1	theme	soluble	1181:1187	arg1	contents					1198:1205	soluble pentosan contents	1181:1205	soluble pentosan contents	1181:1205	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	7	1	theme	soluble	1181:1187	arg1	amylose					1156:1162	significantly increased amylose	1132:1162	significantly increased amylose	1132:1162	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	4	2	theme	targeted	512:519	arg1	mutagenesis					521:531	targeted mutagenesis	512:531	targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively	512:650	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	6	3	theme	composition	811:821	arg1	Analyses					792:799	Analyses	792:799	Analyses of starch composition, structure and properties	792:847	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	10	4	theme	different	1720:1728	arg1	backgrounds					1738:1748	different genetic backgrounds	1720:1748	different genetic backgrounds	1720:1748	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	1	5	theme	amylose	161:167	arg1	content					169:175	amylose content	161:175	amylose content	161:175	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	10	6	from	insights	1607:1614	arg1	role					1623:1626	the role	1619:1626	the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits	1619:1887	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	6	7	from	impacts	981:987	arg1	properties					1078:1087	physiochemical and nutritional properties	1047:1087	properties	1078:1087	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	6	7	from	impacts	981:987	arg1	composition					999:1009	starch composition	992:1009	starch composition	992:1009	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	6	7	from	impacts	981:987	arg1	structures					1017:1026	fine structures	1012:1026	fine structures of amylopectin	1012:1041	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	6	8	theme	partial	878:884	arg1	alleles					901:907	partial or triple-null alleles	878:907	partial or triple-null alleles	878:907	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	10	9	from	quality	1709:1715	arg1	backgrounds					1738:1748	different genetic backgrounds	1720:1748	different genetic backgrounds	1720:1748	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	4	10	theme	wheat	564:568	arg1	ZM					588:589	ZM	588:589	ZM	588:589	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	4	10	theme	wheat	564:568	arg1	7698					582:585	a modern winter wheat cv Zhengmai 7698	548:585	a modern winter wheat cv Zhengmai 7698 (ZM)	548:590	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	6	11	theme	fine	1012:1015	arg1	structures					1017:1026	fine structures	1012:1026	fine structures of amylopectin	1012:1041	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	8	12	theme	Baking	1235:1240	arg1	analyses					1250:1257	Baking quality analyses	1235:1257	Baking quality analyses	1235:1257	Baking quality analyses indicated that the high-amylose flours may be used as additives or for making cookies.
33236499	4	13	theme	Zhengmai	573:580	arg1	ZM					588:589	ZM	588:589	ZM	588:589	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	4	13	theme	Zhengmai	573:580	arg1	7698					582:585	a modern winter wheat cv Zhengmai 7698	548:585	a modern winter wheat cv Zhengmai 7698 (ZM)	548:590	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	9	14	theme	targeted	1442:1449	arg1	mutagenesis					1451:1461	targeted mutagenesis	1442:1461	targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties	1442:1530	Collectively, we successfully modified the starch composition, structure and properties through targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties and generated transgene-free high-amylose wheat.
33236499	1	15	dep	offer	203:207	arg1	improve					228:234	improve	228:234	to improve human health	225:247	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	1	15	dep	offer	203:207	arg1	risk					263:266	the risk	259:266	the risk of serious noninfectious diseases	259:300	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	8	16	theme	quality	1242:1248	arg1	analyses					1250:1257	Baking quality analyses	1235:1257	Baking quality analyses	1235:1257	Baking quality analyses indicated that the high-amylose flours may be used as additives or for making cookies.
33236499	10	17	theme	multiple	1780:1787	arg1	applications					1810:1821	multiple breeding and end-use applications	1780:1821	multiple breeding and end-use applications	1780:1821	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	6	18	theme	properties	838:847	arg1	Analyses					792:799	Analyses	792:799	Analyses of starch composition, structure and properties	792:847	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	5	19	from	alleles	750:756	arg1	Bobwhite					768:775	Bobwhite	768:775	Bobwhite	768:775	We generated a series of transgene-free mutant lines either with partial or triple-null TasbeIIa alleles in ZM and Bobwhite, respectively.
33236499	5	19	from	alleles	750:756	arg1	ZM					761:762	ZM	761:762	ZM	761:762	We generated a series of transgene-free mutant lines either with partial or triple-null TasbeIIa alleles in ZM and Bobwhite, respectively.
33236499	10	20	theme	cereal	1826:1831	arg1	species					1838:1844	cereal crop species	1826:1844	cereal crop species	1826:1844	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	1	21	from	content	169:175	arg1	high					153:156	high	153:156	high	153:156	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	6	22	theme	triple-null	936:946	arg1	lines					948:952	triple-null lines	936:952	triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties	936:1087	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	5	23	theme	triple-null	729:739	arg1	alleles					750:756	partial or triple-null TasbeIIa alleles	718:756	partial or triple-null TasbeIIa alleles in ZM and Bobwhite	718:775	We generated a series of transgene-free mutant lines either with partial or triple-null TasbeIIa alleles in ZM and Bobwhite, respectively.
33236499	8	24	theme	high-amylose	1278:1289	arg1	additives					1313:1321	additives	1313:1321	additives	1313:1321	Baking quality analyses indicated that the high-amylose flours may be used as additives or for making cookies.
33236499	8	24	theme	high-amylose	1278:1289	arg1	flours					1291:1296	the high-amylose flours	1274:1296	the high-amylose flours	1274:1296	Baking quality analyses indicated that the high-amylose flours may be used as additives or for making cookies.
33236499	1	25	dep	risk	263:266	arg1	lower					253:257	lower	253:257	lower	253:257	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	4	26	theme	wheat	605:609	arg1	Bobwhite					614:621	a spring wheat cv Bobwhite	596:621	a spring wheat cv Bobwhite by CRISPR/Cas9	596:636	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	1	27	theme	high	153:156	arg1	Foods					147:151	Foods	147:151	Foods high in amylose content and resistant starch (RS)	147:201	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	4	28	from	mutagenesis	521:531	arg1	Bobwhite					614:621	a spring wheat cv Bobwhite	596:621	a spring wheat cv Bobwhite by CRISPR/Cas9	596:636	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	4	28	from	mutagenesis	521:531	arg1	ZM					588:589	ZM	588:589	ZM	588:589	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	4	28	from	mutagenesis	521:531	arg1	7698					582:585	a modern winter wheat cv Zhengmai 7698	548:585	a modern winter wheat cv Zhengmai 7698 (ZM)	548:590	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	9	29	theme	spring	1509:1514	arg1	varieties					1522:1530	both winter and spring wheat varieties	1493:1530	both winter and spring wheat varieties	1493:1530	Collectively, we successfully modified the starch composition, structure and properties through targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties and generated transgene-free high-amylose wheat.
33236499	6	30	theme	triple-null	889:899	arg1	alleles					901:907	partial or triple-null alleles	878:907	partial or triple-null alleles	878:907	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	2	31	theme	staple	350:355	arg1	wheat					310:314	Common wheat	303:314	Common wheat (Triticum aestivum L.)	303:337	Common wheat (Triticum aestivum L.) is a major staple food crop globally.
33236499	2	31	theme	staple	350:355	arg1	crop					362:365	a major staple food crop	342:365	a major staple food crop	342:365	Common wheat (Triticum aestivum L.) is a major staple food crop globally.
33236499	7	32	theme	increased	1146:1154	arg1	amylose					1156:1162	significantly increased amylose	1132:1162	significantly increased amylose	1132:1162	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	7	32	theme	increased	1146:1154	arg1	contents					1198:1205	soluble pentosan contents	1181:1205	soluble pentosan contents	1181:1205	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	7	32	theme	increased	1146:1154	arg1	protein					1169:1175	protein	1169:1175	protein	1169:1175	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	7	32	theme	increased	1146:1154	arg1	RS					1165:1166	RS	1165:1166	RS	1165:1166	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	0	33	theme	structure	36:44	arg1	Modification					0:11	Modification	0:11	Modification of starch composition, structure and properties through editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9.	0:145	Modification of starch composition, structure and properties through editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9.
33236499	5	34	theme	partial	718:724	arg1	alleles					750:756	partial or triple-null TasbeIIa alleles	718:756	partial or triple-null TasbeIIa alleles in ZM and Bobwhite	718:775	We generated a series of transgene-free mutant lines either with partial or triple-null TasbeIIa alleles in ZM and Bobwhite, respectively.
33236499	8	35	theme	making	1330:1335	arg1	cookies					1337:1343	making cookies	1330:1343	making cookies	1330:1343	Baking quality analyses indicated that the high-amylose flours may be used as additives or for making cookies.
33236499	0	36	theme	starch	16:21	arg1	composition					23:33	starch composition	16:33	starch composition	16:33	Modification of starch composition, structure and properties through editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9.
33236499	9	37	theme	high-amylose	1561:1572	arg1	wheat					1574:1578	transgene-free high-amylose wheat	1546:1578	transgene-free high-amylose wheat	1546:1578	Collectively, we successfully modified the starch composition, structure and properties through targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties and generated transgene-free high-amylose wheat.
33236499	6	38	theme	profound	972:979	arg1	impacts					981:987	more profound impacts	967:987	more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties	967:1087	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	4	39	theme	high-amylose	485:496	arg1	wheat					498:502	high-amylose wheat	485:502	high-amylose wheat	485:502	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	10	40	theme	genome	1854:1859	arg1	editing					1861:1867	genome editing	1854:1867	genome editing for health benefits	1854:1887	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	5	41	theme	mutant	693:698	arg1	lines					700:704	transgene-free mutant lines	678:704	transgene-free mutant lines	678:704	We generated a series of transgene-free mutant lines either with partial or triple-null TasbeIIa alleles in ZM and Bobwhite, respectively.
33236499	3	42	theme	wheat	426:430	arg1	varieties					432:440	modern wheat varieties	419:440	modern wheat varieties	419:440	However, the RS contents in the grains of modern wheat varieties are low.
33236499	1	43	theme	noninfectious	279:291	arg1	diseases					293:300	serious noninfectious diseases	271:300	serious noninfectious diseases	271:300	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	2	44	theme	Common	303:308	arg1	wheat					310:314	Common wheat	303:314	Common wheat (Triticum aestivum L.)	303:337	Common wheat (Triticum aestivum L.) is a major staple food crop globally.
33236499	2	44	theme	Common	303:308	arg1	crop					362:365	a major staple food crop	342:365	a major staple food crop	342:365	Common wheat (Triticum aestivum L.) is a major staple food crop globally.
33236499	2	44	theme	Common	303:308	arg1	Triticum					317:324	Triticum	317:324	Triticum	317:324	Common wheat (Triticum aestivum L.) is a major staple food crop globally.
33236499	7	45	theme	human	1221:1225	arg1	health					1227:1232	human health	1221:1232	human health	1221:1232	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	4	46	theme	TaSBEIIa	536:543	arg1	mutagenesis					521:531	targeted mutagenesis	512:531	targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively	512:650	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	1	47	theme	great	209:213	arg1	potential					215:223	great potential	209:223	great potential	209:223	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	5	48	theme	lines	700:704	arg1	series					668:673	a series	666:673	a series of transgene-free mutant lines	666:704	We generated a series of transgene-free mutant lines either with partial or triple-null TasbeIIa alleles in ZM and Bobwhite, respectively.
33236499	10	49	from	composition	1662:1672	arg1	backgrounds					1738:1748	different genetic backgrounds	1720:1748	different genetic backgrounds	1720:1748	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	10	50	theme	end-use	1701:1707	arg1	quality					1709:1715	end-use quality	1701:1715	end-use quality	1701:1715	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	10	51	from	structure	1675:1683	arg1	backgrounds					1738:1748	different genetic backgrounds	1720:1748	different genetic backgrounds	1720:1748	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	7	52	theme	pentosan	1189:1196	arg1	contents					1198:1205	soluble pentosan contents	1181:1205	soluble pentosan contents	1181:1205	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	7	52	theme	pentosan	1189:1196	arg1	amylose					1156:1162	significantly increased amylose	1132:1162	significantly increased amylose	1132:1162	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	1	53	theme	human	236:240	arg1	health					242:247	human health	236:247	human health	236:247	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	6	54	theme	starch	804:809	arg1	composition					811:821	starch composition	804:821	starch composition	804:821	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	10	55	from	properties	1686:1695	arg1	backgrounds					1738:1748	different genetic backgrounds	1720:1748	different genetic backgrounds	1720:1748	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	10	56	theme	genetic	1730:1736	arg1	backgrounds					1738:1748	different genetic backgrounds	1720:1748	different genetic backgrounds	1720:1748	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	9	57	theme	starch	1389:1394	arg1	composition					1396:1406	the starch composition	1385:1406	the starch composition	1385:1406	Collectively, we successfully modified the starch composition, structure and properties through targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties and generated transgene-free high-amylose wheat.
33236499	9	58	from	TaSBEIIa	1466:1473	arg1	varieties					1522:1530	both winter and spring wheat varieties	1493:1530	both winter and spring wheat varieties	1493:1530	Collectively, we successfully modified the starch composition, structure and properties through targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties and generated transgene-free high-amylose wheat.
33236499	9	59	from	mutagenesis	1451:1461	arg1	varieties					1522:1530	both winter and spring wheat varieties	1493:1530	both winter and spring wheat varieties	1493:1530	Collectively, we successfully modified the starch composition, structure and properties through targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties and generated transgene-free high-amylose wheat.
33236499	7	60	contain	possessed	1122:1130	arg2	RS					1165:1166	RS	1165:1166	RS	1165:1166	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	7	60	contain	possessed	1122:1130	arg2	protein					1169:1175	protein	1169:1175	protein	1169:1175	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	7	60	contain	possessed	1122:1130	arg1	flours					1094:1099	The flours	1090:1099	The flours of triple-null lines	1090:1120	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	7	60	contain	possessed	1122:1130	arg2	contents					1198:1205	soluble pentosan contents	1181:1205	soluble pentosan contents	1181:1205	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	7	60	contain	possessed	1122:1130	arg2	amylose					1156:1162	significantly increased amylose	1132:1162	significantly increased amylose	1132:1162	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	0	61	theme	wheat	115:119	arg1	varieties					121:129	wheat varieties	115:129	wheat varieties	115:129	Modification of starch composition, structure and properties through editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9.
33236499	10	62	theme	RS	1764:1765	arg1	content					1767:1773	RS content	1764:1773	RS content with multiple breeding and end-use applications in cereal crop species	1764:1844	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	5	63	theme	TasbeIIa	741:748	arg1	alleles					750:756	partial or triple-null TasbeIIa alleles	718:756	partial or triple-null TasbeIIa alleles in ZM and Bobwhite	718:775	We generated a series of transgene-free mutant lines either with partial or triple-null TasbeIIa alleles in ZM and Bobwhite, respectively.
33236499	9	64	theme	winter	1498:1503	arg1	varieties					1522:1530	both winter and spring wheat varieties	1493:1530	both winter and spring wheat varieties	1493:1530	Collectively, we successfully modified the starch composition, structure and properties through targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties and generated transgene-free high-amylose wheat.
33236499	4	65	theme	winter	557:562	arg1	ZM					588:589	ZM	588:589	ZM	588:589	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	4	65	theme	winter	557:562	arg1	7698					582:585	a modern winter wheat cv Zhengmai 7698	548:585	a modern winter wheat cv Zhengmai 7698 (ZM)	548:590	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	10	66	theme	end-use	1802:1808	arg1	applications					1810:1821	multiple breeding and end-use applications	1780:1821	multiple breeding and end-use applications	1780:1821	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	0	67	from	editing	69:75	arg1	spring					108:113	spring	108:113	spring	108:113	Modification of starch composition, structure and properties through editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9.
33236499	0	67	from	editing	69:75	arg1	winter					97:102	winter	97:102	winter	97:102	Modification of starch composition, structure and properties through editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9.
33236499	6	68	with	dependent	921:929	arg1	lines					948:952	triple-null lines	936:952	triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties	936:1087	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	4	69	theme	cv	570:571	arg1	ZM					588:589	ZM	588:589	ZM	588:589	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	4	69	theme	cv	570:571	arg1	7698					582:585	a modern winter wheat cv Zhengmai 7698	548:585	a modern winter wheat cv Zhengmai 7698 (ZM)	548:590	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	10	70	theme	deep	1602:1605	arg1	insights					1607:1614	deep insights	1602:1614	deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits	1602:1887	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	10	71	theme	breeding	1789:1796	arg1	applications					1810:1821	multiple breeding and end-use applications	1780:1821	multiple breeding and end-use applications	1780:1821	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	4	72	theme	cv	611:612	arg1	Bobwhite					614:621	a spring wheat cv Bobwhite	596:621	a spring wheat cv Bobwhite by CRISPR/Cas9	596:636	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	10	73	theme	crop	1833:1836	arg1	species					1838:1844	cereal crop species	1826:1844	cereal crop species	1826:1844	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	1	74	from	starch	191:196	arg1	high					153:156	high	153:156	high	153:156	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	9	75	theme	TaSBEIIa	1466:1473	arg1	mutagenesis					1451:1461	targeted mutagenesis	1442:1461	targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties	1442:1530	Collectively, we successfully modified the starch composition, structure and properties through targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties and generated transgene-free high-amylose wheat.
33236499	1	76	theme	resistant	181:189	arg1	starch					191:196	resistant starch	181:196	resistant starch (RS)	181:201	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	1	76	theme	resistant	181:189	arg1	RS					199:200	RS	199:200	RS	199:200	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	0	77	theme	TaSBEIIa	80:87	arg1	editing					69:75	editing	69:75	editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9	69:144	Modification of starch composition, structure and properties through editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9.
33236499	9	78	from	varieties	1522:1530	arg1	mutagenesis					1451:1461	targeted mutagenesis	1442:1461	targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties	1442:1530	Collectively, we successfully modified the starch composition, structure and properties through targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties and generated transgene-free high-amylose wheat.
33236499	10	79	theme	TaSBEIIa	1631:1638	arg1	role					1623:1626	the role	1619:1626	the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits	1619:1887	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	4	80	theme	spring	598:603	arg1	Bobwhite					614:621	a spring wheat cv Bobwhite	596:621	a spring wheat cv Bobwhite by CRISPR/Cas9	596:636	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	1	81	from	high	153:156	arg1	content					169:175	amylose content	161:175	amylose content	161:175	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	1	81	from	high	153:156	arg1	starch					191:196	resistant starch	181:196	resistant starch (RS)	181:201	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	1	81	from	high	153:156	arg1	RS					199:200	RS	199:200	RS	199:200	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	10	82	from	content	1767:1773	arg1	species					1838:1844	cereal crop species	1826:1844	cereal crop species	1826:1844	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	6	83	theme	alleles	901:907	arg1	dependent					921:929	dependent	921:929	dependent	921:929	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	6	83	theme	alleles	901:907	arg1	effects					867:873	the effects	863:873	the effects of partial or triple-null alleles	863:907	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	0	84	dep	winter	97:102	arg1	varieties					121:129	wheat varieties	115:129	wheat varieties	115:129	Modification of starch composition, structure and properties through editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9.
33236499	2	85	dep	Triticum	317:324	arg1	L.					335:336	Triticum aestivum L.	317:336	Triticum aestivum L.	317:336	Common wheat (Triticum aestivum L.) is a major staple food crop globally.
33236499	9	86	theme	wheat	1516:1520	arg1	varieties					1522:1530	both winter and spring wheat varieties	1493:1530	both winter and spring wheat varieties	1493:1530	Collectively, we successfully modified the starch composition, structure and properties through targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties and generated transgene-free high-amylose wheat.
33236499	10	87	with	content	1767:1773	arg1	applications					1810:1821	multiple breeding and end-use applications	1780:1821	multiple breeding and end-use applications	1780:1821	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	3	88	theme	RS	390:391	arg1	low					446:448	low	446:448	low	446:448	However, the RS contents in the grains of modern wheat varieties are low.
33236499	3	88	theme	RS	390:391	arg1	contents					393:400	the RS contents	386:400	the RS contents in the grains of modern wheat varieties	386:440	However, the RS contents in the grains of modern wheat varieties are low.
33236499	7	89	theme	lines	1116:1120	arg1	flours					1094:1099	The flours	1090:1099	The flours of triple-null lines	1090:1120	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33236499	6	90	theme	starch	992:997	arg1	composition					999:1009	starch composition	992:1009	starch composition	992:1009	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	0	91	theme	composition	23:33	arg1	Modification					0:11	Modification	0:11	Modification of starch composition, structure and properties through editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9.	0:145	Modification of starch composition, structure and properties through editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9.
33236499	9	92	theme	transgene-free	1546:1559	arg1	wheat					1574:1578	transgene-free high-amylose wheat	1546:1578	transgene-free high-amylose wheat	1546:1578	Collectively, we successfully modified the starch composition, structure and properties through targeted mutagenesis of TaSBEIIa by CRISPR/Cas9 in both winter and spring wheat varieties and generated transgene-free high-amylose wheat.
33236499	4	93	theme	wheat	498:502	arg1	generation					471:480	the generation	467:480	the generation of high-amylose wheat	467:502	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	10	94	theme	starch	1655:1660	arg1	composition					1662:1672	starch composition	1655:1672	starch composition	1655:1672	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	5	95	theme	transgene-free	678:691	arg1	lines					700:704	transgene-free mutant lines	678:704	transgene-free mutant lines	678:704	We generated a series of transgene-free mutant lines either with partial or triple-null TasbeIIa alleles in ZM and Bobwhite, respectively.
33236499	8	96	used	used	1305:1308	arg2	flours					1291:1296	the high-amylose flours	1274:1296	the high-amylose flours	1274:1296	Baking quality analyses indicated that the high-amylose flours may be used as additives or for making cookies.
33236499	8	96	used	used	1305:1308	arg2	additives					1313:1321	additives	1313:1321	additives	1313:1321	Baking quality analyses indicated that the high-amylose flours may be used as additives or for making cookies.
33236499	3	97	from	contents	393:400	arg1	grains					409:414	the grains	405:414	the grains of modern wheat varieties	405:440	However, the RS contents in the grains of modern wheat varieties are low.
33236499	2	98	theme	food	357:360	arg1	wheat					310:314	Common wheat	303:314	Common wheat (Triticum aestivum L.)	303:337	Common wheat (Triticum aestivum L.) is a major staple food crop globally.
33236499	2	98	theme	food	357:360	arg1	crop					362:365	a major staple food crop	342:365	a major staple food crop	342:365	Common wheat (Triticum aestivum L.) is a major staple food crop globally.
33236499	0	99	theme	properties	50:59	arg1	Modification					0:11	Modification	0:11	Modification of starch composition, structure and properties through editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9.	0:145	Modification of starch composition, structure and properties through editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9.
33236499	1	100	theme	serious	271:277	arg1	diseases					293:300	serious noninfectious diseases	271:300	serious noninfectious diseases	271:300	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	6	101	theme	nutritional	1066:1076	arg1	properties					1078:1087	physiochemical and nutritional properties	1047:1087	properties	1078:1087	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	3	102	theme	varieties	432:440	arg1	grains					409:414	the grains	405:414	the grains of modern wheat varieties	405:440	However, the RS contents in the grains of modern wheat varieties are low.
33236499	1	103	theme	diseases	293:300	arg1	risk					263:266	the risk	259:266	the risk of serious noninfectious diseases	259:300	Foods high in amylose content and resistant starch (RS) offer great potential to improve human health and lower the risk of serious noninfectious diseases.
33236499	6	104	theme	physiochemical	1047:1060	arg1	properties					1078:1087	physiochemical and nutritional properties	1047:1087	properties	1078:1087	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	10	105	theme	health	1873:1878	arg1	benefits					1880:1887	health benefits	1873:1887	health benefits	1873:1887	Our finding provides deep insights on the role of TaSBEIIa in determining starch composition, structure, properties and end-use quality in different genetic backgrounds and improving RS content with multiple breeding and end-use applications in cereal crop species through genome editing for health benefits.
33236499	3	106	theme	modern	419:424	arg1	varieties					432:440	modern wheat varieties	419:440	modern wheat varieties	419:440	However, the RS contents in the grains of modern wheat varieties are low.
33236499	6	107	theme	amylopectin	1031:1041	arg1	properties					1078:1087	physiochemical and nutritional properties	1047:1087	properties	1078:1087	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	6	107	theme	amylopectin	1031:1041	arg1	composition					999:1009	starch composition	992:1009	starch composition	992:1009	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	6	107	theme	amylopectin	1031:1041	arg1	structures					1017:1026	fine structures	1012:1026	fine structures of amylopectin	1012:1041	Analyses of starch composition, structure and properties revealed that the effects of partial or triple-null alleles were dosage dependent with triple-null lines demonstrated more profound impacts on starch composition, fine structures of amylopectin and physiochemical and nutritional properties.
33236499	2	108	theme	major	344:348	arg1	wheat					310:314	Common wheat	303:314	Common wheat (Triticum aestivum L.)	303:337	Common wheat (Triticum aestivum L.) is a major staple food crop globally.
33236499	2	108	theme	major	344:348	arg1	crop					362:365	a major staple food crop	342:365	a major staple food crop	342:365	Common wheat (Triticum aestivum L.) is a major staple food crop globally.
33236499	4	109	theme	modern	550:555	arg1	ZM					588:589	ZM	588:589	ZM	588:589	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	4	109	theme	modern	550:555	arg1	7698					582:585	a modern winter wheat cv Zhengmai 7698	548:585	a modern winter wheat cv Zhengmai 7698 (ZM)	548:590	Here, we report the generation of high-amylose wheat through targeted mutagenesis of TaSBEIIa in a modern winter wheat cv Zhengmai 7698 (ZM) and a spring wheat cv Bobwhite by CRISPR/Cas9, respectively.
33236499	5	110	dep	alleles	750:756	arg1	either					706:711	either	706:711	either	706:711	We generated a series of transgene-free mutant lines either with partial or triple-null TasbeIIa alleles in ZM and Bobwhite, respectively.
33236499	7	111	theme	triple-null	1104:1114	arg1	lines					1116:1120	triple-null lines	1104:1120	triple-null lines	1104:1120	The flours of triple-null lines possessed significantly increased amylose, RS, protein and soluble pentosan contents which benefit human health.
33928820	2	0	theme	Central	427:433	arg1	design					445:450	Central composite design	427:450	Central composite design from response surface methodology of Design Expert-10 software	427:513	Central composite design from response surface methodology of Design Expert-10 software executed the experimental design to correlate experimental factors with desired responses.
33928820	4	1	theme	desirability	880:891	arg1	function					893:900	a desirability function	878:900	a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration	878:1069	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	7	2	from	existence	1332:1340	arg1	OPTS					1372:1375	OPTS	1372:1375	OPTS	1372:1375	Fourier transforms infrared spectra confirmed the existence of selected organic groups in OPTS, which eventually signifies the applied method.
33928820	6	3	theme	microscopic	1211:1221	arg1	images					1223:1228	Electron microscopic images	1202:1228	Electron microscopic images	1202:1228	Electron microscopic images display the amalgamation of flocs through bridging.
33928820	4	4	theme	1.68 g L-1	939:948	arg1	dose					960:963	1.68 g L-1 coagulant dose	939:963	1.68 g L-1 coagulant dose	939:963	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	1	5	theme	oxygen	213:218	arg1	demand					220:225	chemical oxygen demand	204:225	chemical oxygen demand (COD; around 4142 mg L-1)	204:251	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	1	5	theme	oxygen	213:218	arg1	COD					228:230	COD;	228:231	COD; around 4142 mg L-1	228:250	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	5	6	dep	coefficient	1102:1112	arg1	0.96					1129:1132	0.96	1129:1132	0.96	1129:1132	Better results of correlation coefficient (R2 = 0.98 and 0.96) and predicted R2 (0.94 and 0.84) indicates the model significance.
33928820	5	6	dep	coefficient	1102:1112	arg1	R2 = 0.98					1115:1123	R2 = 0.98	1115:1123	R2 = 0.98	1115:1123	Better results of correlation coefficient (R2 = 0.98 and 0.96) and predicted R2 (0.94 and 0.84) indicates the model significance.
33928820	1	7	theme	novel	294:298	arg1	combination					300:310	a novel combination	292:310	a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS)	292:393	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	1	8	from	leachate	275:282	arg1	removal					149:155	The removal	145:155	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS)	145:393	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	0	9	from	leachate	135:142	arg1	removal					93:99	the removal	89:99	the removal of COD and colour from stabilized leachate	89:142	Optimization of the humic acid separation and coagulation with natural starch by RSM for the removal of COD and colour from stabilized leachate.
33928820	5	10	theme	model	1182:1186	arg1	significance					1188:1199	the model significance	1178:1199	the model significance	1178:1199	Better results of correlation coefficient (R2 = 0.98 and 0.96) and predicted R2 (0.94 and 0.84) indicates the model significance.
33928820	4	11	dep	colour	832:837	arg1	removal					865:871	removal	865:871	removal	865:871	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	7	12	theme	organic	1354:1360	arg1	groups					1362:1367	selected organic groups	1345:1367	selected organic groups	1345:1367	Fourier transforms infrared spectra confirmed the existence of selected organic groups in OPTS, which eventually signifies the applied method.
33928820	4	13	theme	dose	960:963	arg1	condition					926:934	the optimum condition	914:934	the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration	914:1069	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	2	14	from	methodology	474:484	arg1	design					445:450	Central composite design	427:450	Central composite design from response surface methodology of Design Expert-10 software	427:513	Central composite design from response surface methodology of Design Expert-10 software executed the experimental design to correlate experimental factors with desired responses.
33928820	2	15	theme	surface	466:472	arg1	methodology					474:484	response surface methodology	457:484	response surface methodology of Design Expert-10 software	457:513	Central composite design from response surface methodology of Design Expert-10 software executed the experimental design to correlate experimental factors with desired responses.
33928820	7	16	theme	groups	1362:1367	arg1	existence					1332:1340	the existence	1328:1340	the existence of selected organic groups in OPTS, which eventually signifies the applied method	1328:1422	Fourier transforms infrared spectra confirmed the existence of selected organic groups in OPTS, which eventually signifies the applied method.
33928820	3	17	dep	dosage	690:695	arg1	e.g.					675:678	e.g.	675:678	e.g.	675:678	Analysis of variance developed the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD).
33928820	4	18	theme	35.75 minutes	1029:1041	arg1	condition					926:934	the optimum condition	914:934	the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration	914:1069	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	2	19	theme	response	457:464	arg1	methodology					474:484	response surface methodology	457:484	response surface methodology of Design Expert-10 software	457:513	Central composite design from response surface methodology of Design Expert-10 software executed the experimental design to correlate experimental factors with desired responses.
33928820	1	20	theme	humic	315:319	arg1	extraction					326:335	humic acid extraction	315:335	humic acid extraction	315:335	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	6	21	theme	Electron	1202:1209	arg1	images					1223:1228	Electron microscopic images	1202:1228	Electron microscopic images	1202:1228	Electron microscopic images display the amalgamation of flocs through bridging.
33928820	3	22	theme	%	773:773	arg1	removal					775:781	% removal	773:781	% removal of colour	773:791	Analysis of variance developed the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD).
33928820	3	22	theme	%	773:773	arg1	COD					794:796	COD	794:796	COD	794:796	Analysis of variance developed the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD).
33928820	1	23	theme	acid	321:324	arg1	extraction					326:335	humic acid extraction	315:335	humic acid extraction	315:335	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	5	24	theme	correlation	1090:1100	arg1	coefficient					1102:1112	correlation coefficient	1090:1112	correlation coefficient (R2 = 0.98 and 0.96)	1090:1133	Better results of correlation coefficient (R2 = 0.98 and 0.96) and predicted R2 (0.94 and 0.84) indicates the model significance.
33928820	7	25	theme	selected	1345:1352	arg1	groups					1362:1367	selected organic groups	1345:1367	selected organic groups	1345:1367	Fourier transforms infrared spectra confirmed the existence of selected organic groups in OPTS, which eventually signifies the applied method.
33928820	6	26	theme	flocs	1258:1262	arg1	amalgamation					1242:1253	the amalgamation	1238:1253	the amalgamation of flocs	1238:1262	Electron microscopic images display the amalgamation of flocs through bridging.
33928820	4	27	theme	optimum	918:924	arg1	condition					926:934	the optimum condition	914:934	the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration	914:1069	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	1	28	theme	extraction	326:335	arg1	combination					300:310	a novel combination	292:310	a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS)	292:393	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	2	29	theme	desired	587:593	arg1	responses					595:603	desired responses	587:603	desired responses	587:603	Central composite design from response surface methodology of Design Expert-10 software executed the experimental design to correlate experimental factors with desired responses.
33928820	2	30	theme	experimental	528:539	arg1	design					541:546	the experimental design	524:546	the experimental design	524:546	Central composite design from response surface methodology of Design Expert-10 software executed the experimental design to correlate experimental factors with desired responses.
33928820	2	31	theme	Design	489:494	arg1	software					506:513	Design Expert-10 software	489:513	Design Expert-10 software	489:513	Central composite design from response surface methodology of Design Expert-10 software executed the experimental design to correlate experimental factors with desired responses.
33928820	3	32	theme	quadratic	641:649	arg1	model					651:655	the quadratic model	637:655	the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD)	637:797	Analysis of variance developed the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD).
33928820	7	33	theme	applied	1409:1415	arg1	method					1417:1422	the applied method	1405:1422	the applied method	1405:1422	Fourier transforms infrared spectra confirmed the existence of selected organic groups in OPTS, which eventually signifies the applied method.
33928820	4	34	theme	16.43 minutes	995:1007	arg1	condition					926:934	the optimum condition	914:934	the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration	914:1069	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	1	35	theme	concentrated	160:171	arg1	Pt-Co					193:197	around 5039 Pt-Co	181:197	around 5039 Pt-Co	181:197	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	1	35	theme	concentrated	160:171	arg1	colour					173:178	concentrated colour	160:178	concentrated colour (around 5039 Pt-Co)	160:198	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	0	36	theme	humic	20:24	arg1	separation					31:40	the humic acid separation	16:40	the humic acid separation	16:40	Optimization of the humic acid separation and coagulation with natural starch by RSM for the removal of COD and colour from stabilized leachate.
33928820	4	37	from	condition	926:934	arg1	function					893:900	a desirability function	878:900	a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration	878:1069	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	0	38	theme	COD	104:106	arg1	removal					93:99	the removal	89:99	the removal of COD and colour from stabilized leachate	89:142	Optimization of the humic acid separation and coagulation with natural starch by RSM for the removal of COD and colour from stabilized leachate.
33928820	1	39	theme	colour	173:178	arg1	removal					149:155	The removal	145:155	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS)	145:393	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	3	40	theme	mixing	703:708	arg1	speed					710:714	slow mixing speed	698:714	slow mixing speed	698:714	Analysis of variance developed the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD).
33928820	2	41	theme	Expert-10	496:504	arg1	software					506:513	Design Expert-10 software	489:513	Design Expert-10 software	489:513	Central composite design from response surface methodology of Design Expert-10 software executed the experimental design to correlate experimental factors with desired responses.
33928820	3	42	theme	variance	618:625	arg1	Analysis					606:613	Analysis	606:613	Analysis of variance	606:625	Analysis of variance developed the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD).
33928820	4	43	theme	mixing	1013:1018	arg1	time					1020:1023	mixing time	1013:1023	mixing time	1013:1023	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	0	44	theme	separation	31:40	arg1	Optimization					0:11	Optimization	0:11	Optimization of the humic acid separation and coagulation with natural starch by RSM for the removal of COD and colour from stabilized leachate.	0:143	Optimization of the humic acid separation and coagulation with natural starch by RSM for the removal of COD and colour from stabilized leachate.
33928820	5	45	theme	coefficient	1102:1112	arg1	results					1079:1085	Better results	1072:1085	Better results of correlation coefficient (R2 = 0.98 and 0.96) and predicted R2 (0.94 and 0.84)	1072:1166	Better results of correlation coefficient (R2 = 0.98 and 0.96) and predicted R2 (0.94 and 0.84) indicates the model significance.
33928820	0	46	theme	colour	112:117	arg1	removal					93:99	the removal	89:99	the removal of COD and colour from stabilized leachate	89:142	Optimization of the humic acid separation and coagulation with natural starch by RSM for the removal of COD and colour from stabilized leachate.
33928820	1	47	theme	coagulation	341:351	arg1	combination					300:310	a novel combination	292:310	a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS)	292:393	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	1	48	with	coagulation	341:351	arg1	OPTS					389:392	natural oil palm trunk starch (OPTS)	358:393	natural oil palm trunk starch (OPTS)	358:393	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	2	49	theme	experimental	561:572	arg1	factors					574:580	experimental factors	561:580	experimental factors	561:580	Central composite design from response surface methodology of Design Expert-10 software executed the experimental design to correlate experimental factors with desired responses.
33928820	0	50	theme	acid	26:29	arg1	separation					31:40	the humic acid separation	16:40	the humic acid separation	16:40	Optimization of the humic acid separation and coagulation with natural starch by RSM for the removal of COD and colour from stabilized leachate.
33928820	1	51	theme	demand	220:225	arg1	removal					149:155	The removal	145:155	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS)	145:393	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	3	52	dep	responses	762:770	arg1	removal					775:781	% removal	773:781	% removal of colour	773:791	Analysis of variance developed the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD).
33928820	3	52	dep	responses	762:770	arg1	COD					794:796	COD	794:796	COD	794:796	Analysis of variance developed the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD).
33928820	3	53	theme	colour	786:791	arg1	removal					775:781	% removal	773:781	% removal of colour	773:791	Analysis of variance developed the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD).
33928820	3	53	theme	colour	786:791	arg1	COD					794:796	COD	794:796	COD	794:796	Analysis of variance developed the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD).
33928820	5	54	theme	Better	1072:1077	arg1	results					1079:1085	Better results	1072:1085	Better results of correlation coefficient (R2 = 0.98 and 0.96) and predicted R2 (0.94 and 0.84)	1072:1166	Better results of correlation coefficient (R2 = 0.98 and 0.96) and predicted R2 (0.94 and 0.84) indicates the model significance.
33928820	0	55	theme	coagulation	46:56	arg1	Optimization					0:11	Optimization	0:11	Optimization of the humic acid separation and coagulation with natural starch by RSM for the removal of COD and colour from stabilized leachate.	0:143	Optimization of the humic acid separation and coagulation with natural starch by RSM for the removal of COD and colour from stabilized leachate.
33928820	1	56	theme	matured	258:264	arg1	leachate					275:282	matured landfill leachate	258:282	matured landfill leachate	258:282	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	0	57	theme	stabilized	124:133	arg1	leachate					135:142	stabilized leachate	124:142	stabilized leachate	124:142	Optimization of the humic acid separation and coagulation with natural starch by RSM for the removal of COD and colour from stabilized leachate.
33928820	1	58	theme	natural	358:364	arg1	OPTS					389:392	natural oil palm trunk starch (OPTS)	358:393	natural oil palm trunk starch (OPTS)	358:393	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	3	59	theme	coagulant	680:688	arg1	dosage					690:695	coagulant dosage	680:695	coagulant dosage	680:695	Analysis of variance developed the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD).
33928820	4	60	theme	0.836	905:909	arg1	function					893:900	a desirability function	878:900	a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration	878:1069	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	1	61	theme	landfill	266:273	arg1	leachate					275:282	matured landfill leachate	258:282	matured landfill leachate	258:282	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	2	62	theme	software	506:513	arg1	methodology					474:484	response surface methodology	457:484	response surface methodology of Design Expert-10 software	457:513	Central composite design from response surface methodology of Design Expert-10 software executed the experimental design to correlate experimental factors with desired responses.
33928820	1	63	theme	oil	366:368	arg1	OPTS					389:392	natural oil palm trunk starch (OPTS)	358:393	natural oil palm trunk starch (OPTS)	358:393	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	4	64	theme	mixing	981:986	arg1	speed					988:992	19.11 rpm slow mixing speed	966:992	19.11 rpm slow mixing speed	966:992	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	4	65	theme	slow	976:979	arg1	speed					988:992	19.11 rpm slow mixing speed	966:992	19.11 rpm slow mixing speed	966:992	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	3	66	theme	centrifugation	729:742	arg1	duration					744:751	centrifugation duration	729:751	centrifugation duration	729:751	Analysis of variance developed the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD).
33928820	3	67	theme	slow	698:701	arg1	speed					710:714	slow mixing speed	698:714	slow mixing speed	698:714	Analysis of variance developed the quadratic model for four factors (e.g. coagulant dosage, slow mixing speed and time and centrifugation duration) and two responses (% removal of colour, COD).
33928820	1	68	theme	palm	370:373	arg1	OPTS					389:392	natural oil palm trunk starch (OPTS)	358:393	natural oil palm trunk starch (OPTS)	358:393	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	7	69	theme	infrared	1301:1308	arg1	spectra					1310:1316	infrared spectra	1301:1316	infrared spectra confirmed the existence of selected organic groups in OPTS, which eventually signifies the applied method	1301:1422	Fourier transforms infrared spectra confirmed the existence of selected organic groups in OPTS, which eventually signifies the applied method.
33928820	1	70	with	extraction	326:335	arg1	OPTS					389:392	natural oil palm trunk starch (OPTS)	358:393	natural oil palm trunk starch (OPTS)	358:393	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	1	71	theme	trunk	375:379	arg1	OPTS					389:392	natural oil palm trunk starch (OPTS)	358:393	natural oil palm trunk starch (OPTS)	358:393	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	0	72	with	coagulation	46:56	arg1	starch					71:76	natural starch	63:76	natural starch	63:76	Optimization of the humic acid separation and coagulation with natural starch by RSM for the removal of COD and colour from stabilized leachate.
33928820	4	73	theme	speed	988:992	arg1	condition					926:934	the optimum condition	914:934	the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration	914:1069	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	0	74	theme	natural	63:69	arg1	starch					71:76	natural starch	63:76	natural starch	63:76	Optimization of the humic acid separation and coagulation with natural starch by RSM for the removal of COD and colour from stabilized leachate.
33928820	1	75	theme	starch	381:386	arg1	OPTS					389:392	natural oil palm trunk starch (OPTS)	358:393	natural oil palm trunk starch (OPTS)	358:393	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	4	76	theme	centrifugation	1047:1060	arg1	duration					1062:1069	centrifugation duration	1047:1069	centrifugation duration	1047:1069	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	4	77	theme	highest	824:830	arg1	colour					832:837	the highest colour	820:837	the highest colour (84.96%)	820:846	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	4	77	theme	highest	824:830	arg1	%					845:845	84.96%	840:845	84.96%	840:845	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	4	78	theme	19.11 rpm	966:974	arg1	speed					988:992	19.11 rpm slow mixing speed	966:992	19.11 rpm slow mixing speed	966:992	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	5	79	theme	predicted	1139:1147	arg1	0.84					1162:1165	0.84	1162:1165	0.84	1162:1165	Better results of correlation coefficient (R2 = 0.98 and 0.96) and predicted R2 (0.94 and 0.84) indicates the model significance.
33928820	5	79	theme	predicted	1139:1147	arg1	0.94					1153:1156	0.94	1153:1156	0.94	1153:1156	Better results of correlation coefficient (R2 = 0.98 and 0.96) and predicted R2 (0.94 and 0.84) indicates the model significance.
33928820	5	79	theme	predicted	1139:1147	arg1	R2					1149:1150	predicted R2	1139:1150	predicted R2 (0.94 and 0.84)	1139:1166	Better results of correlation coefficient (R2 = 0.98 and 0.96) and predicted R2 (0.94 and 0.84) indicates the model significance.
33928820	2	80	theme	composite	435:443	arg1	design					445:450	Central composite design	427:450	Central composite design from response surface methodology of Design Expert-10 software	427:513	Central composite design from response surface methodology of Design Expert-10 software executed the experimental design to correlate experimental factors with desired responses.
33928820	5	81	theme	R2	1149:1150	arg1	results					1079:1085	Better results	1072:1085	Better results of correlation coefficient (R2 = 0.98 and 0.96) and predicted R2 (0.94 and 0.84)	1072:1166	Better results of correlation coefficient (R2 = 0.98 and 0.96) and predicted R2 (0.94 and 0.84) indicates the model significance.
33928820	0	82	with	separation	31:40	arg1	starch					71:76	natural starch	63:76	natural starch	63:76	Optimization of the humic acid separation and coagulation with natural starch by RSM for the removal of COD and colour from stabilized leachate.
33928820	4	83	theme	coagulant	950:958	arg1	dose					960:963	1.68 g L-1 coagulant dose	939:963	1.68 g L-1 coagulant dose	939:963	The model confirmed the highest colour (84.96%) and COD (48.84%) removal with a desirability function of 0.836 at the optimum condition of 1.68 g L-1 coagulant dose, 19.11 rpm slow mixing speed, 16.43 minutes for mixing time and 35.75 minutes for centrifugation duration.
33928820	1	84	theme	chemical	204:211	arg1	demand					220:225	chemical oxygen demand	204:225	chemical oxygen demand (COD; around 4142 mg L-1)	204:251	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
33928820	1	84	theme	chemical	204:211	arg1	COD					228:230	COD;	228:231	COD; around 4142 mg L-1	228:250	The removal of concentrated colour (around 5039 Pt-Co) and chemical oxygen demand (COD; around 4142 mg L-1) from matured landfill leachate through a novel combination of humic acid extraction and coagulation with natural oil palm trunk starch (OPTS) was investigated in this study.
34420719	5	0	theme	tailored	932:939	arg1	composition					941:951	the tailored composition	928:951	the tailored composition of BCNFs with PAM	928:969	From further studies on drug release, we demonstrated that the tailored composition of BCNFs with PAM retarded drug release by a factor of two compared to PAM only while enabling on-demand drug release in response to the applied compressive stress.
34420719	4	1	theme	mechanical	810:819	arg1	properties					821:830	the mechanical properties	806:830	the mechanical properties determined by the BCNF aspect ratio	806:866	We also observed that the swelling kinetics depended on the mechanical properties determined by the BCNF aspect ratio.
34420719	3	2	theme	compression	543:553	arg1	strength					555:562	the compression strength	539:562	the compression strength of PAM/BCNF composite hydrogels	539:594	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	5	3	theme	two	1008:1010	arg1	factor					998:1003	a factor	996:1003	a factor of two	996:1010	From further studies on drug release, we demonstrated that the tailored composition of BCNFs with PAM retarded drug release by a factor of two compared to PAM only while enabling on-demand drug release in response to the applied compressive stress.
34420719	3	4	theme	PAM	738:740	arg1	meshes					742:747	PAM meshes	738:747	PAM meshes	738:747	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	2	5	theme	network	340:346	arg1	structure					348:356	its semi-interpenetrating network structure	314:356	its semi-interpenetrating network structure in which bacterial cellulose nanofibers (BCNFs) penetrate through a polyacrylamide (PAM) mesh	314:450	This hybrid hydrogel is specialized by its semi-interpenetrating network structure in which bacterial cellulose nanofibers (BCNFs) penetrate through a polyacrylamide (PAM) mesh.
34420719	4	6	theme	swelling	776:783	arg1	kinetics					785:792	the swelling kinetics	772:792	the swelling kinetics	772:792	We also observed that the swelling kinetics depended on the mechanical properties determined by the BCNF aspect ratio.
34420719	6	7	theme	delivery	1244:1251	arg1	system					1177:1182	our BCNFs-reinforced hydrogel system	1147:1182	our BCNFs-reinforced hydrogel system	1147:1182	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	6	7	theme	delivery	1244:1251	arg1	patch					1253:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	2	8	theme	semi-interpenetrating	318:338	arg1	structure					348:356	its semi-interpenetrating network structure	314:356	its semi-interpenetrating network structure in which bacterial cellulose nanofibers (BCNFs) penetrate through a polyacrylamide (PAM) mesh	314:450	This hybrid hydrogel is specialized by its semi-interpenetrating network structure in which bacterial cellulose nanofibers (BCNFs) penetrate through a polyacrylamide (PAM) mesh.
34420719	1	9	theme	hydrogel	174:181	arg1	system					183:188	a cellulose-reinforced hybrid hydrogel system	144:188	a cellulose-reinforced hybrid hydrogel system that not only increases mechanical strength, but also allows on-demand drug release	144:272	Herein, we propose a cellulose-reinforced hybrid hydrogel system that not only increases mechanical strength, but also allows on-demand drug release.
34420719	6	10	theme	hydrogel	1168:1175	arg1	system					1177:1182	our BCNFs-reinforced hydrogel system	1147:1182	our BCNFs-reinforced hydrogel system	1147:1182	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	6	10	theme	hydrogel	1168:1175	arg1	patch					1253:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	3	11	theme	PAM/BCNF	567:574	arg1	hydrogels					586:594	PAM/BCNF composite hydrogels	567:594	PAM/BCNF composite hydrogels	567:594	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	3	12	theme	interpenetrating	472:487	arg1	BCNFs					489:493	the interpenetrating BCNFs	468:493	the interpenetrating BCNFs with a higher aspect ratio of 240	468:527	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	3	13	theme	composite	576:584	arg1	hydrogels					586:594	PAM/BCNF composite hydrogels	567:594	PAM/BCNF composite hydrogels	567:594	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	1	14	theme	mechanical	214:223	arg1	strength					225:232	mechanical strength	214:232	mechanical strength	214:232	Herein, we propose a cellulose-reinforced hybrid hydrogel system that not only increases mechanical strength, but also allows on-demand drug release.
34420719	2	15	theme	bacterial	367:375	arg1	BCNFs					399:403	BCNFs	399:403	BCNFs	399:403	This hybrid hydrogel is specialized by its semi-interpenetrating network structure in which bacterial cellulose nanofibers (BCNFs) penetrate through a polyacrylamide (PAM) mesh.
34420719	2	15	theme	bacterial	367:375	arg1	nanofibers					387:396	bacterial cellulose nanofibers	367:396	bacterial cellulose nanofibers (BCNFs)	367:404	This hybrid hydrogel is specialized by its semi-interpenetrating network structure in which bacterial cellulose nanofibers (BCNFs) penetrate through a polyacrylamide (PAM) mesh.
34420719	6	16	theme	BCNFs-reinforced	1151:1166	arg1	system					1177:1182	our BCNFs-reinforced hydrogel system	1147:1182	our BCNFs-reinforced hydrogel system	1147:1182	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	6	16	theme	BCNFs-reinforced	1151:1166	arg1	patch					1253:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	0	17	theme	Bacterial	0:8	arg1	cellulose					10:18	Bacterial cellulose	0:18	Bacterial cellulose	0:18	Bacterial cellulose nanofibrils-reinforced composite hydrogels for mechanical compression-responsive on-demand drug release.
34420719	5	18	with	BCNFs	956:960	arg1	PAM					967:969	PAM	967:969	PAM	967:969	From further studies on drug release, we demonstrated that the tailored composition of BCNFs with PAM retarded drug release by a factor of two compared to PAM only while enabling on-demand drug release in response to the applied compressive stress.
34420719	5	19	theme	drug	980:983	arg1	release					985:991	drug release	980:991	drug release by a factor of two compared to PAM	980:1026	From further studies on drug release, we demonstrated that the tailored composition of BCNFs with PAM retarded drug release by a factor of two compared to PAM only while enabling on-demand drug release in response to the applied compressive stress.
34420719	2	20	theme	polyacrylamide	426:439	arg1	mesh					447:450	a polyacrylamide (PAM) mesh	424:450	a polyacrylamide (PAM) mesh	424:450	This hybrid hydrogel is specialized by its semi-interpenetrating network structure in which bacterial cellulose nanofibers (BCNFs) penetrate through a polyacrylamide (PAM) mesh.
34420719	0	21	theme	composite	43:51	arg1	hydrogels					53:61	composite hydrogels	43:61	composite hydrogels for mechanical compression-responsive on-demand drug release	43:122	Bacterial cellulose nanofibrils-reinforced composite hydrogels for mechanical compression-responsive on-demand drug release.
34420719	6	22	theme	drug	1239:1242	arg1	system					1177:1182	our BCNFs-reinforced hydrogel system	1147:1182	our BCNFs-reinforced hydrogel system	1147:1182	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	6	22	theme	drug	1239:1242	arg1	patch					1253:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	3	23	theme	higher	502:507	arg1	ratio					516:520	a higher aspect ratio	500:520	a higher aspect ratio of 240	500:527	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	6	24	theme	stress-responsive	1215:1231	arg1	system					1177:1182	our BCNFs-reinforced hydrogel system	1147:1182	our BCNFs-reinforced hydrogel system	1147:1182	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	6	24	theme	stress-responsive	1215:1231	arg1	patch					1253:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	3	25	theme	aspect	509:514	arg1	ratio					516:520	a higher aspect ratio	500:520	a higher aspect ratio of 240	500:527	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	5	26	theme	BCNFs	956:960	arg1	composition					941:951	the tailored composition	928:951	the tailored composition of BCNFs with PAM	928:969	From further studies on drug release, we demonstrated that the tailored composition of BCNFs with PAM retarded drug release by a factor of two compared to PAM only while enabling on-demand drug release in response to the applied compressive stress.
34420719	5	27	theme	applied	1090:1096	arg1	stress					1110:1115	the applied compressive stress	1086:1115	the applied compressive stress	1086:1115	From further studies on drug release, we demonstrated that the tailored composition of BCNFs with PAM retarded drug release by a factor of two compared to PAM only while enabling on-demand drug release in response to the applied compressive stress.
34420719	5	28	theme	compressive	1098:1108	arg1	stress					1110:1115	the applied compressive stress	1086:1115	the applied compressive stress	1086:1115	From further studies on drug release, we demonstrated that the tailored composition of BCNFs with PAM retarded drug release by a factor of two compared to PAM only while enabling on-demand drug release in response to the applied compressive stress.
34420719	4	29	theme	aspect	855:860	arg1	ratio					862:866	the BCNF aspect ratio	846:866	the BCNF aspect ratio	846:866	We also observed that the swelling kinetics depended on the mechanical properties determined by the BCNF aspect ratio.
34420719	5	30	theme	drug	893:896	arg1	release					898:904	drug release	893:904	drug release	893:904	From further studies on drug release, we demonstrated that the tailored composition of BCNFs with PAM retarded drug release by a factor of two compared to PAM only while enabling on-demand drug release in response to the applied compressive stress.
34420719	1	31	theme	on-demand	251:259	arg1	release					266:272	on-demand drug release	251:272	on-demand drug release	251:272	Herein, we propose a cellulose-reinforced hybrid hydrogel system that not only increases mechanical strength, but also allows on-demand drug release.
34420719	0	32	theme	compression-responsive	78:99	arg1	release					116:122	mechanical compression-responsive on-demand drug release	67:122	mechanical compression-responsive on-demand drug release	67:122	Bacterial cellulose nanofibrils-reinforced composite hydrogels for mechanical compression-responsive on-demand drug release.
34420719	3	33	theme	reinforcing	679:689	arg1	effect					691:696	the reinforcing effect	675:696	the reinforcing effect of the rigid natural nanofibers between PAM meshes	675:747	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	5	34	theme	on-demand	1048:1056	arg1	release					1063:1069	on-demand drug release	1048:1069	on-demand drug release	1048:1069	From further studies on drug release, we demonstrated that the tailored composition of BCNFs with PAM retarded drug release by a factor of two compared to PAM only while enabling on-demand drug release in response to the applied compressive stress.
34420719	3	35	theme	240	525:527	arg1	ratio					516:520	a higher aspect ratio	500:520	a higher aspect ratio of 240	500:527	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	0	36	theme	mechanical	67:76	arg1	release					116:122	mechanical compression-responsive on-demand drug release	67:122	mechanical compression-responsive on-demand drug release	67:122	Bacterial cellulose nanofibrils-reinforced composite hydrogels for mechanical compression-responsive on-demand drug release.
34420719	6	37	theme	mechanical	1204:1213	arg1	system					1177:1182	our BCNFs-reinforced hydrogel system	1147:1182	our BCNFs-reinforced hydrogel system	1147:1182	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	6	37	theme	mechanical	1204:1213	arg1	patch					1253:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	3	38	theme	natural	711:717	arg1	nanofibers					719:728	the rigid natural nanofibers	701:728	the rigid natural nanofibers between PAM meshes	701:747	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	5	39	theme	drug	1058:1061	arg1	release					1063:1069	on-demand drug release	1048:1069	on-demand drug release	1048:1069	From further studies on drug release, we demonstrated that the tailored composition of BCNFs with PAM retarded drug release by a factor of two compared to PAM only while enabling on-demand drug release in response to the applied compressive stress.
34420719	1	40	theme	cellulose-reinforced	146:165	arg1	system					183:188	a cellulose-reinforced hybrid hydrogel system	144:188	a cellulose-reinforced hybrid hydrogel system that not only increases mechanical strength, but also allows on-demand drug release	144:272	Herein, we propose a cellulose-reinforced hybrid hydrogel system that not only increases mechanical strength, but also allows on-demand drug release.
34420719	6	41	theme	smart	1233:1237	arg1	system					1177:1182	our BCNFs-reinforced hydrogel system	1147:1182	our BCNFs-reinforced hydrogel system	1147:1182	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	6	41	theme	smart	1233:1237	arg1	patch					1253:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	a mechanical stress-responsive smart drug delivery patch	1202:1257	These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch.
34420719	3	42	theme	nanofibers	719:728	arg1	effect					691:696	the reinforcing effect	675:696	the reinforcing effect of the rigid natural nanofibers between PAM meshes	675:747	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	5	43	from	studies	882:888	arg1	release					898:904	drug release	893:904	drug release	893:904	From further studies on drug release, we demonstrated that the tailored composition of BCNFs with PAM retarded drug release by a factor of two compared to PAM only while enabling on-demand drug release in response to the applied compressive stress.
34420719	1	44	theme	hybrid	167:172	arg1	system					183:188	a cellulose-reinforced hybrid hydrogel system	144:188	a cellulose-reinforced hybrid hydrogel system that not only increases mechanical strength, but also allows on-demand drug release	144:272	Herein, we propose a cellulose-reinforced hybrid hydrogel system that not only increases mechanical strength, but also allows on-demand drug release.
34420719	1	45	theme	drug	261:264	arg1	release					266:272	on-demand drug release	251:272	on-demand drug release	251:272	Herein, we propose a cellulose-reinforced hybrid hydrogel system that not only increases mechanical strength, but also allows on-demand drug release.
34420719	3	46	with	BCNFs	489:493	arg1	ratio					516:520	a higher aspect ratio	500:520	a higher aspect ratio of 240	500:527	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	3	47	theme	hydrogels	586:594	arg1	strength					555:562	the compression strength	539:562	the compression strength of PAM/BCNF composite hydrogels	539:594	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	2	48	theme	cellulose	377:385	arg1	BCNFs					399:403	BCNFs	399:403	BCNFs	399:403	This hybrid hydrogel is specialized by its semi-interpenetrating network structure in which bacterial cellulose nanofibers (BCNFs) penetrate through a polyacrylamide (PAM) mesh.
34420719	2	48	theme	cellulose	377:385	arg1	nanofibers					387:396	bacterial cellulose nanofibers	367:396	bacterial cellulose nanofibers (BCNFs)	367:404	This hybrid hydrogel is specialized by its semi-interpenetrating network structure in which bacterial cellulose nanofibers (BCNFs) penetrate through a polyacrylamide (PAM) mesh.
34420719	0	49	theme	drug	111:114	arg1	release					116:122	mechanical compression-responsive on-demand drug release	67:122	mechanical compression-responsive on-demand drug release	67:122	Bacterial cellulose nanofibrils-reinforced composite hydrogels for mechanical compression-responsive on-demand drug release.
34420719	3	50	theme	rigid	705:709	arg1	nanofibers					719:728	the rigid natural nanofibers	701:728	the rigid natural nanofibers between PAM meshes	701:747	We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes.
34420719	4	51	theme	BCNF	850:853	arg1	ratio					862:866	the BCNF aspect ratio	846:866	the BCNF aspect ratio	846:866	We also observed that the swelling kinetics depended on the mechanical properties determined by the BCNF aspect ratio.
34420719	5	52	theme	further	874:880	arg1	studies					882:888	further studies	874:888	further studies on drug release	874:904	From further studies on drug release, we demonstrated that the tailored composition of BCNFs with PAM retarded drug release by a factor of two compared to PAM only while enabling on-demand drug release in response to the applied compressive stress.
34420719	2	53	theme	PAM	442:444	arg1	mesh					447:450	a polyacrylamide (PAM) mesh	424:450	a polyacrylamide (PAM) mesh	424:450	This hybrid hydrogel is specialized by its semi-interpenetrating network structure in which bacterial cellulose nanofibers (BCNFs) penetrate through a polyacrylamide (PAM) mesh.
34420719	0	54	theme	on-demand	101:109	arg1	release					116:122	mechanical compression-responsive on-demand drug release	67:122	mechanical compression-responsive on-demand drug release	67:122	Bacterial cellulose nanofibrils-reinforced composite hydrogels for mechanical compression-responsive on-demand drug release.
34420719	2	55	theme	hybrid	280:285	arg1	hydrogel					287:294	This hybrid hydrogel	275:294	This hybrid hydrogel	275:294	This hybrid hydrogel is specialized by its semi-interpenetrating network structure in which bacterial cellulose nanofibers (BCNFs) penetrate through a polyacrylamide (PAM) mesh.
33965799	7	0	theme	relevant	1369:1376	arg1	cells					1378:1382	relevant cells	1369:1382	relevant cells	1369:1382	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	9	1	theme	3D	1791:1792	arg1	platforms					1814:1822	promising 3D tissue regenerative platforms	1781:1822	promising 3D tissue regenerative platforms	1781:1822	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	1	theme	3D	1791:1792	arg1	nanohybrids					1557:1567	the nanohybrids	1553:1567	the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation),	1553:1758	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	7	2	theme	growth	1251:1256	arg1	molecules					1214:1222	therapeutic molecules	1202:1222	therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil)	1202:1280	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	7	2	theme	growth	1251:1256	arg1	factor					1258:1263	fibroblast growth factor 2	1240:1265	fibroblast growth factor 2	1240:1265	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	2	3	theme	inorganic/organic	348:364	arg1	nanounits					366:374	biomedical inorganic/organic nanounits	337:374	biomedical inorganic/organic nanounits	337:374	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	9	4	theme	regenerative	1801:1812	arg1	platforms					1814:1822	promising 3D tissue regenerative platforms	1781:1822	promising 3D tissue regenerative platforms	1781:1822	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	4	theme	regenerative	1801:1812	arg1	nanohybrids					1557:1567	the nanohybrids	1553:1567	the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation),	1553:1758	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	3	5	with	thin-shelled	540:551	arg1	chitosan					558:565	chitosan	558:565	chitosan	558:565	The inorganic core thin-shelled with chitosan could constitute as high as 90%, strikingly contrasted with the conventional composites.
33965799	5	6	theme	integrin-mediated	945:961	arg1	adhesions					969:977	stimulated integrin-mediated focal adhesions	934:977	stimulated integrin-mediated focal adhesions	934:977	The nanohybrids, with the nano-roughened surface topography, could accelerate the cellular responses through stimulated integrin-mediated focal adhesions.
33965799	4	7	theme	resisted	725:732	arg1	stress					743:748	resisted external stress	725:748	resisted external stress	725:748	The Chit@IOC nanohybrids were highly resilient under cyclic load and resisted external stress almost an order of magnitude effectively than the conventional composites.
33965799	1	8	theme	ultra-microstructure	215:234	arg1	properties					254:263	their ultra-microstructure and extraordinary properties	209:263	their ultra-microstructure and extraordinary properties	209:263	Natural inorganic/organic nanohybrids are a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties.
33965799	7	9	theme	therapeutic	1202:1212	arg1	phenamil					1272:1279	phenamil	1272:1279	phenamil	1272:1279	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	7	9	theme	therapeutic	1202:1212	arg1	dexamethasone					1225:1237	dexamethasone	1225:1237	dexamethasone	1225:1237	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	7	9	theme	therapeutic	1202:1212	arg1	molecules					1214:1222	therapeutic molecules	1202:1222	therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil)	1202:1280	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	7	9	theme	therapeutic	1202:1212	arg1	factor					1258:1263	fibroblast growth factor 2	1240:1265	fibroblast growth factor 2	1240:1265	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	5	10	theme	cellular	907:914	arg1	responses					916:924	the cellular responses	903:924	the cellular responses	903:924	The nanohybrids, with the nano-roughened surface topography, could accelerate the cellular responses through stimulated integrin-mediated focal adhesions.
33965799	8	11	theme	in	1407:1408	arg1	model					1432:1436	the in vivo calvarium defect model	1403:1436	the in vivo calvarium defect model with 3D-printed scaffold forms	1403:1467	When implanted in the in vivo calvarium defect model with 3D-printed scaffold forms, the therapeutic nanohybrids were proven to accelerate new bone formation.
33965799	8	12	theme	calvarium	1415:1423	arg1	model					1432:1436	the in vivo calvarium defect model	1403:1436	the in vivo calvarium defect model with 3D-printed scaffold forms	1403:1467	When implanted in the in vivo calvarium defect model with 3D-printed scaffold forms, the therapeutic nanohybrids were proven to accelerate new bone formation.
33965799	9	13	theme	unique	1620:1625	arg1	activation					1747:1756	cellular activation	1738:1756	cellular activation	1738:1756	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	13	theme	unique	1620:1625	arg1	content					1659:1665	ultrahigh inorganic content	1639:1665	ultrahigh inorganic content	1639:1665	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	13	theme	unique	1620:1625	arg1	delivery					1724:1731	multiple-therapeutics delivery	1702:1731	multiple-therapeutics delivery	1702:1731	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	13	theme	unique	1620:1625	arg1	properties					1627:1636	their unique properties	1614:1636	their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation)	1614:1757	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	13	theme	unique	1620:1625	arg1	nano-topography					1668:1682	nano-topography	1668:1682	nano-topography	1668:1682	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	13	theme	unique	1620:1625	arg1	resilience					1690:1699	high resilience	1685:1699	high resilience	1685:1699	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	6	14	theme	multiple	1019:1026	arg1	molecules					1040:1048	multiple therapeutic molecules	1019:1048	multiple therapeutic molecules	1019:1048	The nanohybrids were also able to load multiple therapeutic molecules in the core and shell compartment and then release sequentially, demonstrating controlled delivery systems.
33965799	5	15	with	nanohybrids	829:839	arg1	topography					874:883	the nano-roughened surface topography	847:883	the nano-roughened surface topography	847:883	The nanohybrids, with the nano-roughened surface topography, could accelerate the cellular responses through stimulated integrin-mediated focal adhesions.
33965799	1	16	theme	fascinating	161:171	arg1	nanohybrids					143:153	Natural inorganic/organic nanohybrids	117:153	Natural inorganic/organic nanohybrids	117:153	Natural inorganic/organic nanohybrids are a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties.
33965799	1	16	theme	fascinating	161:171	arg1	model					173:177	a fascinating model	159:177	a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties	159:263	Natural inorganic/organic nanohybrids are a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties.
33965799	8	17	theme	3D-printed	1443:1452	arg1	forms					1463:1467	3D-printed scaffold forms	1443:1467	3D-printed scaffold forms	1443:1467	When implanted in the in vivo calvarium defect model with 3D-printed scaffold forms, the therapeutic nanohybrids were proven to accelerate new bone formation.
33965799	0	18	theme	core	84:87	arg1	nanounits					106:114	bioactive inorganic core / chitosan shell nanounits	64:114	bioactive inorganic core / chitosan shell nanounits	64:114	Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits.
33965799	2	19	theme	unique-structured	282:298	arg1	nanohybrids					300:310	unique-structured nanohybrids	282:310	unique-structured nanohybrids	282:310	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	9	20	theme	inorganic	1649:1657	arg1	properties					1627:1636	their unique properties	1614:1636	their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation)	1614:1757	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	20	theme	inorganic	1649:1657	arg1	content					1659:1665	ultrahigh inorganic content	1639:1665	ultrahigh inorganic content	1639:1665	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	0	21	theme	chitosan	91:98	arg1	nanounits					106:114	bioactive inorganic core / chitosan shell nanounits	64:114	bioactive inorganic core / chitosan shell nanounits	64:114	Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits.
33965799	9	22	dep	properties	1627:1636	arg1	activation					1747:1756	cellular activation	1738:1756	cellular activation	1738:1756	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	22	dep	properties	1627:1636	arg1	content					1659:1665	ultrahigh inorganic content	1639:1665	ultrahigh inorganic content	1639:1665	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	22	dep	properties	1627:1636	arg1	delivery					1724:1731	multiple-therapeutics delivery	1702:1731	multiple-therapeutics delivery	1702:1731	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	22	dep	properties	1627:1636	arg1	properties					1627:1636	their unique properties	1614:1636	their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation)	1614:1757	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	22	dep	properties	1627:1636	arg1	nano-topography					1668:1682	nano-topography	1668:1682	nano-topography	1668:1682	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	22	dep	properties	1627:1636	arg1	resilience					1690:1699	high resilience	1685:1699	high resilience	1685:1699	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	4	23	theme	conventional	800:811	arg1	composites					813:822	the conventional composites	796:822	the conventional composites	796:822	The Chit@IOC nanohybrids were highly resilient under cyclic load and resisted external stress almost an order of magnitude effectively than the conventional composites.
33965799	7	24	theme	pro-angiogenic	1329:1342	arg1	events					1359:1364	the anti-inflammatory, pro-angiogenic and osteogenic events	1306:1364	the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells	1306:1382	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	1	25	from	model	173:177	arg1	biomaterials					182:193	biomaterials	182:193	biomaterials design due to their ultra-microstructure and extraordinary properties	182:263	Natural inorganic/organic nanohybrids are a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties.
33965799	8	26	theme	defect	1425:1430	arg1	model					1432:1436	the in vivo calvarium defect model	1403:1436	the in vivo calvarium defect model with 3D-printed scaffold forms	1403:1467	When implanted in the in vivo calvarium defect model with 3D-printed scaffold forms, the therapeutic nanohybrids were proven to accelerate new bone formation.
33965799	3	27	theme	inorganic	525:533	arg1	thin-shelled					540:551	The inorganic core thin-shelled	521:551	The inorganic core thin-shelled with chitosan	521:565	The inorganic core thin-shelled with chitosan could constitute as high as 90%, strikingly contrasted with the conventional composites.
33965799	7	28	theme	anti-inflammatory	1310:1326	arg1	events					1359:1364	the anti-inflammatory, pro-angiogenic and osteogenic events	1306:1364	the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells	1306:1382	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	2	29	theme	@	515:515	arg1	IOC					516:518	Chit@IOC	511:518	Chit@IOC	511:518	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	1	30	dep	biomaterials	182:193	arg1	design					195:200	design	195:200	design	195:200	Natural inorganic/organic nanohybrids are a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties.
33965799	0	31	theme	Therapeutic	0:10	arg1	nanohybrids					32:42	Therapeutic tissue regenerative nanohybrids	0:42	Therapeutic tissue regenerative nanohybrids	0:42	Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits.
33965799	9	32	theme	multiple-therapeutics	1702:1722	arg1	properties					1627:1636	their unique properties	1614:1636	their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation)	1614:1757	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	32	theme	multiple-therapeutics	1702:1722	arg1	delivery					1724:1731	multiple-therapeutics delivery	1702:1731	multiple-therapeutics delivery	1702:1731	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	2	33	theme	shell	496:500	arg1	self-assembly					320:332	self-assembly	320:332	self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC	320:518	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	0	34	theme	regenerative	19:30	arg1	nanohybrids					32:42	Therapeutic tissue regenerative nanohybrids	0:42	Therapeutic tissue regenerative nanohybrids	0:42	Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits.
33965799	1	35	theme	inorganic/organic	125:141	arg1	nanohybrids					143:153	Natural inorganic/organic nanohybrids	117:153	Natural inorganic/organic nanohybrids	117:153	Natural inorganic/organic nanohybrids are a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties.
33965799	1	35	theme	inorganic/organic	125:141	arg1	model					173:177	a fascinating model	159:177	a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties	159:263	Natural inorganic/organic nanohybrids are a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties.
33965799	8	36	theme	bone	1528:1531	arg1	formation					1533:1541	new bone formation	1524:1541	new bone formation	1524:1541	When implanted in the in vivo calvarium defect model with 3D-printed scaffold forms, the therapeutic nanohybrids were proven to accelerate new bone formation.
33965799	9	37	theme	cellular	1738:1745	arg1	activation					1747:1756	cellular activation	1738:1756	cellular activation	1738:1756	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	37	theme	cellular	1738:1745	arg1	properties					1627:1636	their unique properties	1614:1636	their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation)	1614:1757	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	6	38	theme	delivery	1140:1147	arg1	systems					1149:1155	controlled delivery systems	1129:1155	controlled delivery systems	1129:1155	The nanohybrids were also able to load multiple therapeutic molecules in the core and shell compartment and then release sequentially, demonstrating controlled delivery systems.
33965799	5	39	theme	surface	866:872	arg1	topography					874:883	the nano-roughened surface topography	847:883	the nano-roughened surface topography	847:883	The nanohybrids, with the nano-roughened surface topography, could accelerate the cellular responses through stimulated integrin-mediated focal adhesions.
33965799	2	40	theme	nanoparticle	409:420	arg1	core					422:425	bioactive inorganic nanoparticle core	389:425	bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica)	389:481	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	4	41	theme	Chit	660:663	arg1	resilient					693:701	resilient	693:701	resilient	693:701	The Chit@IOC nanohybrids were highly resilient under cyclic load and resisted external stress almost an order of magnitude effectively than the conventional composites.
33965799	4	41	theme	Chit	660:663	arg1	nanohybrids					669:679	The Chit@IOC nanohybrids	656:679	The Chit@IOC nanohybrids	656:679	The Chit@IOC nanohybrids were highly resilient under cyclic load and resisted external stress almost an order of magnitude effectively than the conventional composites.
33965799	0	42	theme	inorganic	74:82	arg1	nanounits					106:114	bioactive inorganic core / chitosan shell nanounits	64:114	bioactive inorganic core / chitosan shell nanounits	64:114	Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits.
33965799	4	43	theme	IOC	665:667	arg1	resilient					693:701	resilient	693:701	resilient	693:701	The Chit@IOC nanohybrids were highly resilient under cyclic load and resisted external stress almost an order of magnitude effectively than the conventional composites.
33965799	4	43	theme	IOC	665:667	arg1	nanohybrids					669:679	The Chit@IOC nanohybrids	656:679	The Chit@IOC nanohybrids	656:679	The Chit@IOC nanohybrids were highly resilient under cyclic load and resisted external stress almost an order of magnitude effectively than the conventional composites.
33965799	6	44	from	load	1014:1017	arg1	compartment					1072:1082	the core and shell compartment	1053:1082	compartment	1072:1082	The nanohybrids were also able to load multiple therapeutic molecules in the core and shell compartment and then release sequentially, demonstrating controlled delivery systems.
33965799	9	45	theme	promising	1781:1789	arg1	platforms					1814:1822	promising 3D tissue regenerative platforms	1781:1822	promising 3D tissue regenerative platforms	1781:1822	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	45	theme	promising	1781:1789	arg1	nanohybrids					1557:1567	the nanohybrids	1553:1567	the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation),	1553:1758	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	7	46	theme	cells	1378:1382	arg1	events					1359:1364	the anti-inflammatory, pro-angiogenic and osteogenic events	1306:1364	the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells	1306:1382	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	7	47	theme	fibroblast	1240:1249	arg1	molecules					1214:1222	therapeutic molecules	1202:1222	therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil)	1202:1280	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	7	47	theme	fibroblast	1240:1249	arg1	factor					1258:1263	fibroblast growth factor 2	1240:1265	fibroblast growth factor 2	1240:1265	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	2	48	theme	nanounits	366:374	arg1	self-assembly					320:332	self-assembly	320:332	self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC	320:518	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	9	49	theme	tissue	1794:1799	arg1	platforms					1814:1822	promising 3D tissue regenerative platforms	1781:1822	promising 3D tissue regenerative platforms	1781:1822	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	49	theme	tissue	1794:1799	arg1	nanohybrids					1557:1567	the nanohybrids	1553:1567	the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation),	1553:1758	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	2	50	theme	biomedical	337:346	arg1	nanounits					366:374	biomedical inorganic/organic nanounits	337:374	biomedical inorganic/organic nanounits	337:374	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	9	51	theme	Chit	1589:1592	arg1	nanounits					1598:1606	Chit@IOC nanounits	1589:1606	Chit@IOC nanounits	1589:1606	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	5	52	theme	stimulated	934:943	arg1	adhesions					969:977	stimulated integrin-mediated focal adhesions	934:977	stimulated integrin-mediated focal adhesions	934:977	The nanohybrids, with the nano-roughened surface topography, could accelerate the cellular responses through stimulated integrin-mediated focal adhesions.
33965799	0	53	theme	bioactive	64:72	arg1	nanounits					106:114	bioactive inorganic core / chitosan shell nanounits	64:114	bioactive inorganic core / chitosan shell nanounits	64:114	Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits.
33965799	4	54	theme	cyclic	709:714	arg1	load					716:719	cyclic load	709:719	cyclic load	709:719	The Chit@IOC nanohybrids were highly resilient under cyclic load and resisted external stress almost an order of magnitude effectively than the conventional composites.
33965799	7	55	theme	osteogenic	1348:1357	arg1	events					1359:1364	the anti-inflammatory, pro-angiogenic and osteogenic events	1306:1364	the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells	1306:1382	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	2	56	theme	bioactive	389:397	arg1	core					422:425	bioactive inorganic nanoparticle core	389:425	bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica)	389:481	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	5	57	theme	focal	963:967	arg1	adhesions					969:977	stimulated integrin-mediated focal adhesions	934:977	stimulated integrin-mediated focal adhesions	934:977	The nanohybrids, with the nano-roughened surface topography, could accelerate the cellular responses through stimulated integrin-mediated focal adhesions.
33965799	6	58	theme	shell	1066:1070	arg1	compartment					1072:1082	the core and shell compartment	1053:1082	compartment	1072:1082	The nanohybrids were also able to load multiple therapeutic molecules in the core and shell compartment and then release sequentially, demonstrating controlled delivery systems.
33965799	9	59	theme	IOC	1594:1596	arg1	nanounits					1598:1606	Chit@IOC nanounits	1589:1606	Chit@IOC nanounits	1589:1606	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	6	60	theme	core	1057:1060	arg1	compartment					1072:1082	the core and shell compartment	1053:1082	compartment	1072:1082	The nanohybrids were also able to load multiple therapeutic molecules in the core and shell compartment and then release sequentially, demonstrating controlled delivery systems.
33965799	7	61	dep	molecules	1214:1222	arg1	phenamil					1272:1279	phenamil	1272:1279	phenamil	1272:1279	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	7	61	dep	molecules	1214:1222	arg1	dexamethasone					1225:1237	dexamethasone	1225:1237	dexamethasone	1225:1237	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	7	61	dep	molecules	1214:1222	arg1	molecules					1214:1222	therapeutic molecules	1202:1222	therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil)	1202:1280	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	7	61	dep	molecules	1214:1222	arg1	factor					1258:1263	fibroblast growth factor 2	1240:1265	fibroblast growth factor 2	1240:1265	The nanohybrids compartmentally-loaded with therapeutic molecules (dexamethasone, fibroblast growth factor 2, and phenamil) were shown to stimulate the anti-inflammatory, pro-angiogenic and osteogenic events of relevant cells.
33965799	9	62	theme	@	1593:1593	arg1	nanounits					1598:1606	Chit@IOC nanounits	1589:1606	Chit@IOC nanounits	1589:1606	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	3	63	theme	conventional	631:642	arg1	composites					644:653	the conventional composites	627:653	the conventional composites	627:653	The inorganic core thin-shelled with chitosan could constitute as high as 90%, strikingly contrasted with the conventional composites.
33965799	6	64	theme	therapeutic	1028:1038	arg1	molecules					1040:1048	multiple therapeutic molecules	1019:1048	multiple therapeutic molecules	1019:1048	The nanohybrids were also able to load multiple therapeutic molecules in the core and shell compartment and then release sequentially, demonstrating controlled delivery systems.
33965799	6	65	theme	controlled	1129:1138	arg1	systems					1149:1155	controlled delivery systems	1129:1155	controlled delivery systems	1129:1155	The nanohybrids were also able to load multiple therapeutic molecules in the core and shell compartment and then release sequentially, demonstrating controlled delivery systems.
33965799	4	66	theme	magnitude	769:777	arg1	order					760:764	an order	757:764	an order of magnitude	757:777	The Chit@IOC nanohybrids were highly resilient under cyclic load and resisted external stress almost an order of magnitude effectively than the conventional composites.
33965799	3	67	theme	core	535:538	arg1	thin-shelled					540:551	The inorganic core thin-shelled	521:551	The inorganic core thin-shelled with chitosan	521:565	The inorganic core thin-shelled with chitosan could constitute as high as 90%, strikingly contrasted with the conventional composites.
33965799	9	68	theme	ultrahigh	1639:1647	arg1	properties					1627:1636	their unique properties	1614:1636	their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation)	1614:1757	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	68	theme	ultrahigh	1639:1647	arg1	content					1659:1665	ultrahigh inorganic content	1639:1665	ultrahigh inorganic content	1639:1665	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	4	69	theme	external	734:741	arg1	stress					743:748	resisted external stress	725:748	resisted external stress	725:748	The Chit@IOC nanohybrids were highly resilient under cyclic load and resisted external stress almost an order of magnitude effectively than the conventional composites.
33965799	0	70	theme	shell	100:104	arg1	nanounits					106:114	bioactive inorganic core / chitosan shell nanounits	64:114	bioactive inorganic core / chitosan shell nanounits	64:114	Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits.
33965799	8	71	theme	scaffold	1454:1461	arg1	forms					1463:1467	3D-printed scaffold forms	1443:1467	3D-printed scaffold forms	1443:1467	When implanted in the in vivo calvarium defect model with 3D-printed scaffold forms, the therapeutic nanohybrids were proven to accelerate new bone formation.
33965799	8	72	dep	in	1407:1408	arg1	vivo					1410:1413	vivo	1410:1413	vivo	1410:1413	When implanted in the in vivo calvarium defect model with 3D-printed scaffold forms, the therapeutic nanohybrids were proven to accelerate new bone formation.
33965799	1	73	theme	extraordinary	240:252	arg1	properties					254:263	their ultra-microstructure and extraordinary properties	209:263	their ultra-microstructure and extraordinary properties	209:263	Natural inorganic/organic nanohybrids are a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties.
33965799	9	74	theme	high	1685:1688	arg1	properties					1627:1636	their unique properties	1614:1636	their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation)	1614:1757	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	74	theme	high	1685:1688	arg1	resilience					1690:1699	high resilience	1685:1699	high resilience	1685:1699	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	8	75	theme	therapeutic	1474:1484	arg1	nanohybrids					1486:1496	the therapeutic nanohybrids	1470:1496	the therapeutic nanohybrids	1470:1496	When implanted in the in vivo calvarium defect model with 3D-printed scaffold forms, the therapeutic nanohybrids were proven to accelerate new bone formation.
33965799	2	76	theme	mesoporous	464:473	arg1	silica					475:480	mesoporous silica	464:480	mesoporous silica	464:480	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	0	77	theme	tissue	12:17	arg1	nanohybrids					32:42	Therapeutic tissue regenerative nanohybrids	0:42	Therapeutic tissue regenerative nanohybrids	0:42	Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits.
33965799	2	78	theme	Chit	511:514	arg1	IOC					516:518	Chit@IOC	511:518	Chit@IOC	511:518	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	1	79	theme	Natural	117:123	arg1	nanohybrids					143:153	Natural inorganic/organic nanohybrids	117:153	Natural inorganic/organic nanohybrids	117:153	Natural inorganic/organic nanohybrids are a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties.
33965799	1	79	theme	Natural	117:123	arg1	model					173:177	a fascinating model	159:177	a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties	159:263	Natural inorganic/organic nanohybrids are a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties.
33965799	8	80	with	model	1432:1436	arg1	forms					1463:1467	3D-printed scaffold forms	1443:1467	3D-printed scaffold forms	1443:1467	When implanted in the in vivo calvarium defect model with 3D-printed scaffold forms, the therapeutic nanohybrids were proven to accelerate new bone formation.
33965799	2	81	dep	core	422:425	arg1	silica					475:480	mesoporous silica	464:480	mesoporous silica	464:480	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	2	81	dep	core	422:425	arg1	hydroxyapatite					428:441	hydroxyapatite	428:441	hydroxyapatite	428:441	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	2	81	dep	core	422:425	arg1	glass					454:458	bioactive glass	444:458	bioactive glass	444:458	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	2	82	theme	chitosan	487:494	arg1	shell					496:500	chitosan shell	487:500	chitosan shell	487:500	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	9	83	with	nanounits	1598:1606	arg1	activation					1747:1756	cellular activation	1738:1756	cellular activation	1738:1756	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	83	with	nanounits	1598:1606	arg1	content					1659:1665	ultrahigh inorganic content	1639:1665	ultrahigh inorganic content	1639:1665	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	83	with	nanounits	1598:1606	arg1	delivery					1724:1731	multiple-therapeutics delivery	1702:1731	multiple-therapeutics delivery	1702:1731	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	83	with	nanounits	1598:1606	arg1	properties					1627:1636	their unique properties	1614:1636	their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation)	1614:1757	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	83	with	nanounits	1598:1606	arg1	nano-topography					1668:1682	nano-topography	1668:1682	nano-topography	1668:1682	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	9	83	with	nanounits	1598:1606	arg1	resilience					1690:1699	high resilience	1685:1699	high resilience	1685:1699	Overall, the nanohybrids self-assembled from Chit@IOC nanounits, with their unique properties (ultrahigh inorganic content, nano-topography, high resilience, multiple-therapeutics delivery, and cellular activation), can be considered as promising 3D tissue regenerative platforms.
33965799	8	84	theme	new	1524:1526	arg1	formation					1533:1541	new bone formation	1524:1541	new bone formation	1524:1541	When implanted in the in vivo calvarium defect model with 3D-printed scaffold forms, the therapeutic nanohybrids were proven to accelerate new bone formation.
33965799	5	85	theme	nano-roughened	851:864	arg1	topography					874:883	the nano-roughened surface topography	847:883	the nano-roughened surface topography	847:883	The nanohybrids, with the nano-roughened surface topography, could accelerate the cellular responses through stimulated integrin-mediated focal adhesions.
33965799	4	86	theme	@	664:664	arg1	resilient					693:701	resilient	693:701	resilient	693:701	The Chit@IOC nanohybrids were highly resilient under cyclic load and resisted external stress almost an order of magnitude effectively than the conventional composites.
33965799	4	86	theme	@	664:664	arg1	nanohybrids					669:679	The Chit@IOC nanohybrids	656:679	The Chit@IOC nanohybrids	656:679	The Chit@IOC nanohybrids were highly resilient under cyclic load and resisted external stress almost an order of magnitude effectively than the conventional composites.
33965799	2	87	theme	inorganic	399:407	arg1	core					422:425	bioactive inorganic nanoparticle core	389:425	bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica)	389:481	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
33965799	2	88	theme	bioactive	444:452	arg1	glass					454:458	bioactive glass	444:458	bioactive glass	444:458	Here, we report unique-structured nanohybrids through self-assembly of biomedical inorganic/organic nanounits, composed of bioactive inorganic nanoparticle core (hydroxyapatite, bioactive glass, or mesoporous silica) and chitosan shell - namely Chit@IOC.
32600705	0	0	theme	bioactivity	103:113	arg1	composites					43:52	Antibacterial alginate/nano-hydroxyapatite composites	0:52	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.	0:160	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	0	0	theme	bioactivity	103:113	arg1	biocompatibility					116:131	biocompatibility	116:131	biocompatibility	116:131	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	0	0	theme	bioactivity	103:113	arg1	Assessment					83:92	Assessment	83:92	Assessment of their bioactivity	83:113	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	0	0	theme	bioactivity	103:113	arg1	activity					152:159	antibacterial activity	138:159	antibacterial activity	138:159	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	2	1	dep	bioceramic	562:571	arg1	nano-hydroxyapatite					584:602	synthetic nano-hydroxyapatite	574:602	synthetic nano-hydroxyapatite	574:602	In this work, two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG) have been designed and assessed for promoting the bone regeneration.
32600705	2	1	dep	bioceramic	562:571	arg1	HA					605:606	HA	605:606	HA	605:606	In this work, two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG) have been designed and assessed for promoting the bone regeneration.
32600705	2	2	dep	biopolymer	615:624	arg1	ALG					644:646	ALG	644:646	ALG	644:646	In this work, two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG) have been designed and assessed for promoting the bone regeneration.
32600705	2	2	dep	biopolymer	615:624	arg1	alginate					634:641	sodium alginate	627:641	sodium alginate	627:641	In this work, two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG) have been designed and assessed for promoting the bone regeneration.
32600705	8	3	theme	main	1572:1575	arg1	strains					1577:1583	the three main strains	1562:1583	the three main strains	1562:1583	Then, the assessment of antibacterial capability against the three main strains cause osteomyelitis was performed.
32600705	2	4	theme	composite	531:539	arg1	materials					541:549	composite materials	531:549	composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG)	531:647	In this work, two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG) have been designed and assessed for promoting the bone regeneration.
32600705	9	5	dep	viability	1638:1646	arg1	study					1648:1652	study	1648:1652	the cell viability study	1629:1652	Finally, the cell viability study and the cellular morphology assay were also carried out.
32600705	6	6	theme	release	1242:1248	arg1	profile					1250:1256	The release profile	1238:1256	The release profile of this drug	1238:1269	The release profile of this drug has been fit with the Ritger-Peppas model, used for studying the release kinetics of hydrogel-based systems.
32600705	7	7	theme	fluid	1483:1487	arg1	SBF					1499:1501	SBF	1499:1501	SBF	1499:1501	The bioactivity of these composites was also evaluated after 30 days of incubation in a simulated body fluid solution (SBF).
32600705	7	7	theme	fluid	1483:1487	arg1	solution					1489:1496	a simulated body fluid solution	1466:1496	a simulated body fluid solution (SBF)	1466:1502	The bioactivity of these composites was also evaluated after 30 days of incubation in a simulated body fluid solution (SBF).
32600705	1	8	dep	integration	435:445	arg1	osseointegration					448:463	osseointegration	448:463	osseointegration	448:463	Bone substitute materials based on bioceramics and polymers have evolved shifting from a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue.
32600705	10	9	theme	other	1785:1789	arg1	properties					1791:1800	their other properties	1779:1800	their other properties	1779:1800	These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
32600705	10	9	theme	other	1785:1789	arg1	properties					1847:1856	their bioactivity and antibacterial properties	1811:1856	their bioactivity and antibacterial properties	1811:1856	These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
32600705	10	10	theme	antibacterial	1833:1845	arg1	properties					1847:1856	their bioactivity and antibacterial properties	1811:1856	their bioactivity and antibacterial properties	1811:1856	These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
32600705	2	11	theme	synthetic	574:582	arg1	nano-hydroxyapatite					584:602	synthetic nano-hydroxyapatite	574:602	synthetic nano-hydroxyapatite	574:602	In this work, two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG) have been designed and assessed for promoting the bone regeneration.
32600705	2	11	theme	synthetic	574:582	arg1	HA					605:606	HA	605:606	HA	605:606	In this work, two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG) have been designed and assessed for promoting the bone regeneration.
32600705	2	12	theme	sodium	627:632	arg1	ALG					644:646	ALG	644:646	ALG	644:646	In this work, two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG) have been designed and assessed for promoting the bone regeneration.
32600705	2	12	theme	sodium	627:632	arg1	alginate					634:641	sodium alginate	627:641	sodium alginate	627:641	In this work, two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG) have been designed and assessed for promoting the bone regeneration.
32600705	5	13	used	used	1081:1084	arg2	spectroscopy					1064:1075	Ultraviolet-Visible (UV-Vis) spectroscopy	1035:1075	Ultraviolet-Visible (UV-Vis) spectroscopy	1035:1075	Ultraviolet-Visible (UV-Vis) spectroscopy was used for obtaining the released concentrations of CIP and Zeta-potential (ζ-potential) was used for characterizing the adsorption of CIP onto nanoparticles.
32600705	1	14	theme	particular	349:358	arg1	conditions					374:383	particular environmental conditions	349:383	particular environmental conditions	349:383	Bone substitute materials based on bioceramics and polymers have evolved shifting from a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue.
32600705	4	15	theme	Fourier	916:922	arg1	spectroscopy					945:956	Fourier transformed-infrared spectroscopy	916:956	Fourier transformed-infrared spectroscopy (FT-IR)	916:964	Therefore, their main features were studied through Fourier transformed-infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM).
32600705	4	15	theme	Fourier	916:922	arg1	FT-IR					959:963	FT-IR	959:963	FT-IR	959:963	Therefore, their main features were studied through Fourier transformed-infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM).
32600705	1	16	theme	environmental	360:372	arg1	conditions					374:383	particular environmental conditions	349:383	particular environmental conditions	349:383	Bone substitute materials based on bioceramics and polymers have evolved shifting from a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue.
32600705	4	17	theme	transmission	995:1006	arg1	microscopy					1017:1026	transmission electron microscopy	995:1026	transmission electron microscopy (TEM)	995:1032	Therefore, their main features were studied through Fourier transformed-infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM).
32600705	4	17	theme	transmission	995:1006	arg1	TEM					1029:1031	TEM	1029:1031	TEM	1029:1031	Therefore, their main features were studied through Fourier transformed-infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM).
32600705	6	18	theme	Ritger-Peppas	1293:1305	arg1	model					1307:1311	the Ritger-Peppas model	1289:1311	the Ritger-Peppas model	1289:1311	The release profile of this drug has been fit with the Ritger-Peppas model, used for studying the release kinetics of hydrogel-based systems.
32600705	3	19	with	material	806:813	arg1	properties					852:861	antibacterial properties	838:861	antibacterial properties	838:861	These materials were loaded with ciprofloxacin (CIP) for obtaining, not only a suitable material for a filling but with antibacterial properties.
32600705	6	20	theme	systems	1371:1377	arg1	kinetics					1344:1351	the release kinetics	1332:1351	the release kinetics of hydrogel-based systems	1332:1377	The release profile of this drug has been fit with the Ritger-Peppas model, used for studying the release kinetics of hydrogel-based systems.
32600705	3	21	theme	antibacterial	838:850	arg1	properties					852:861	antibacterial properties	838:861	antibacterial properties	838:861	These materials were loaded with ciprofloxacin (CIP) for obtaining, not only a suitable material for a filling but with antibacterial properties.
32600705	0	22	theme	alginate/nano-hydroxyapatite	14:41	arg1	composites					43:52	Antibacterial alginate/nano-hydroxyapatite composites	0:52	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.	0:160	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	0	22	theme	alginate/nano-hydroxyapatite	14:41	arg1	biocompatibility					116:131	biocompatibility	116:131	biocompatibility	116:131	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	0	22	theme	alginate/nano-hydroxyapatite	14:41	arg1	Assessment					83:92	Assessment	83:92	Assessment of their bioactivity	83:113	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	0	22	theme	alginate/nano-hydroxyapatite	14:41	arg1	activity					152:159	antibacterial activity	138:159	antibacterial activity	138:159	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	7	23	theme	composites	1405:1414	arg1	bioactivity					1384:1394	The bioactivity	1380:1394	The bioactivity of these composites	1380:1414	The bioactivity of these composites was also evaluated after 30 days of incubation in a simulated body fluid solution (SBF).
32600705	10	24	theme	new	1905:1907	arg1	materials					1892:1900	these materials	1886:1900	these materials	1886:1900	These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
32600705	10	24	theme	new	1905:1907	arg1	devices					1932:1938	new bone filler antibiotic devices	1905:1938	new bone filler antibiotic devices	1905:1938	These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
32600705	5	25	theme	UV-Vis	1056:1061	arg1	spectroscopy					1064:1075	Ultraviolet-Visible (UV-Vis) spectroscopy	1035:1075	Ultraviolet-Visible (UV-Vis) spectroscopy	1035:1075	Ultraviolet-Visible (UV-Vis) spectroscopy was used for obtaining the released concentrations of CIP and Zeta-potential (ζ-potential) was used for characterizing the adsorption of CIP onto nanoparticles.
32600705	0	26	theme	Antibacterial	0:12	arg1	composites					43:52	Antibacterial alginate/nano-hydroxyapatite composites	0:52	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.	0:160	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	0	26	theme	Antibacterial	0:12	arg1	biocompatibility					116:131	biocompatibility	116:131	biocompatibility	116:131	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	0	26	theme	Antibacterial	0:12	arg1	Assessment					83:92	Assessment	83:92	Assessment of their bioactivity	83:113	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	0	26	theme	Antibacterial	0:12	arg1	activity					152:159	antibacterial activity	138:159	antibacterial activity	138:159	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	5	27	theme	CIP	1131:1133	arg1	concentrations					1113:1126	the released concentrations	1100:1126	the released concentrations of CIP	1100:1133	Ultraviolet-Visible (UV-Vis) spectroscopy was used for obtaining the released concentrations of CIP and Zeta-potential (ζ-potential) was used for characterizing the adsorption of CIP onto nanoparticles.
32600705	9	28	theme	cell	1633:1636	arg1	viability					1638:1646	the cell viability	1629:1646	the cell viability study	1629:1652	Finally, the cell viability study and the cellular morphology assay were also carried out.
32600705	5	29	theme	CIP	1214:1216	arg1	adsorption					1200:1209	the adsorption	1196:1209	the adsorption of CIP onto nanoparticles	1196:1235	Ultraviolet-Visible (UV-Vis) spectroscopy was used for obtaining the released concentrations of CIP and Zeta-potential (ζ-potential) was used for characterizing the adsorption of CIP onto nanoparticles.
32600705	3	30	dep	obtaining	775:783	arg1	only					790:793	only	790:793	only	790:793	These materials were loaded with ciprofloxacin (CIP) for obtaining, not only a suitable material for a filling but with antibacterial properties.
32600705	10	31	theme	antibiotic	1921:1930	arg1	materials					1892:1900	these materials	1886:1900	these materials	1886:1900	These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
32600705	10	31	theme	antibiotic	1921:1930	arg1	devices					1932:1938	new bone filler antibiotic devices	1905:1938	new bone filler antibiotic devices	1905:1938	These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
32600705	2	32	theme	materials	541:549	arg1	types					522:526	two types	518:526	two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG)	518:647	In this work, two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG) have been designed and assessed for promoting the bone regeneration.
32600705	10	33	theme	last	1717:1720	arg1	assays					1722:1727	These last assays	1711:1727	These last assays	1711:1727	These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
32600705	0	34	theme	antibacterial	138:150	arg1	composites					43:52	Antibacterial alginate/nano-hydroxyapatite composites	0:52	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.	0:160	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	0	34	theme	antibacterial	138:150	arg1	activity					152:159	antibacterial activity	138:159	antibacterial activity	138:159	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	6	35	theme	hydrogel-based	1356:1369	arg1	systems					1371:1377	hydrogel-based systems	1356:1377	hydrogel-based systems	1356:1377	The release profile of this drug has been fit with the Ritger-Peppas model, used for studying the release kinetics of hydrogel-based systems.
32600705	1	36	dep	materials	178:186	arg1	substitute					167:176	substitute	167:176	substitute	167:176	Bone substitute materials based on bioceramics and polymers have evolved shifting from a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue.
32600705	0	37	theme	tissue	63:68	arg1	engineering					70:80	bone tissue engineering	58:80	bone tissue engineering	58:80	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	1	38	theme	different	391:399	arg1	types					401:405	different types	391:405	different types of cues generating suitable integration (osseointegration for this case)	391:478	Bone substitute materials based on bioceramics and polymers have evolved shifting from a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue.
32600705	10	39	theme	bioactivity	1817:1827	arg1	properties					1847:1856	their bioactivity and antibacterial properties	1811:1856	their bioactivity and antibacterial properties	1811:1856	These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
32600705	0	40	theme	bone	58:61	arg1	engineering					70:80	bone tissue engineering	58:80	bone tissue engineering	58:80	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	4	41	theme	main	881:884	arg1	features					886:893	their main features	875:893	their main features	875:893	Therefore, their main features were studied through Fourier transformed-infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM).
32600705	7	42	theme	body	1478:1481	arg1	SBF					1499:1501	SBF	1499:1501	SBF	1499:1501	The bioactivity of these composites was also evaluated after 30 days of incubation in a simulated body fluid solution (SBF).
32600705	7	42	theme	body	1478:1481	arg1	solution					1489:1496	a simulated body fluid solution	1466:1496	a simulated body fluid solution (SBF)	1466:1502	The bioactivity of these composites was also evaluated after 30 days of incubation in a simulated body fluid solution (SBF).
32600705	1	43	theme	host	491:494	arg1	tissue					496:501	the host tissue	487:501	the host tissue	487:501	Bone substitute materials based on bioceramics and polymers have evolved shifting from a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue.
32600705	1	44	theme	active	314:319	arg1	role					321:324	an active role	311:324	an active role	311:324	Bone substitute materials based on bioceramics and polymers have evolved shifting from a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue.
32600705	9	45	theme	cellular	1662:1669	arg1	assay					1682:1686	the cellular morphology assay	1658:1686	the cellular morphology assay	1658:1686	Finally, the cell viability study and the cellular morphology assay were also carried out.
32600705	5	46	theme	Ultraviolet-Visible	1035:1053	arg1	spectroscopy					1064:1075	Ultraviolet-Visible (UV-Vis) spectroscopy	1035:1075	Ultraviolet-Visible (UV-Vis) spectroscopy	1035:1075	Ultraviolet-Visible (UV-Vis) spectroscopy was used for obtaining the released concentrations of CIP and Zeta-potential (ζ-potential) was used for characterizing the adsorption of CIP onto nanoparticles.
32600705	8	47	dep	capability	1543:1552	arg1	cause					1585:1589	cause	1585:1589	cause osteomyelitis	1585:1603	Then, the assessment of antibacterial capability against the three main strains cause osteomyelitis was performed.
32600705	4	48	theme	X-ray	967:971	arg1	XRD					986:988	XRD	986:988	XRD	986:988	Therefore, their main features were studied through Fourier transformed-infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM).
32600705	4	48	theme	X-ray	967:971	arg1	diffraction					973:983	X-ray diffraction	967:983	X-ray diffraction (XRD)	967:989	Therefore, their main features were studied through Fourier transformed-infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM).
32600705	10	49	theme	filler	1914:1919	arg1	materials					1892:1900	these materials	1886:1900	these materials	1886:1900	These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
32600705	10	49	theme	filler	1914:1919	arg1	devices					1932:1938	new bone filler antibiotic devices	1905:1938	new bone filler antibiotic devices	1905:1938	These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
32600705	6	50	theme	drug	1266:1269	arg1	profile					1250:1256	The release profile	1238:1256	The release profile of this drug	1238:1269	The release profile of this drug has been fit with the Ritger-Peppas model, used for studying the release kinetics of hydrogel-based systems.
32600705	1	51	theme	cues	410:413	arg1	types					401:405	different types	391:405	different types of cues generating suitable integration (osseointegration for this case)	391:478	Bone substitute materials based on bioceramics and polymers have evolved shifting from a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue.
32600705	7	52	theme	simulated	1468:1476	arg1	SBF					1499:1501	SBF	1499:1501	SBF	1499:1501	The bioactivity of these composites was also evaluated after 30 days of incubation in a simulated body fluid solution (SBF).
32600705	7	52	theme	simulated	1468:1476	arg1	solution					1489:1496	a simulated body fluid solution	1466:1496	a simulated body fluid solution (SBF)	1466:1502	The bioactivity of these composites was also evaluated after 30 days of incubation in a simulated body fluid solution (SBF).
32600705	10	53	theme	bone	1909:1912	arg1	materials					1892:1900	these materials	1886:1900	these materials	1886:1900	These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
32600705	10	53	theme	bone	1909:1912	arg1	devices					1932:1938	new bone filler antibiotic devices	1905:1938	new bone filler antibiotic devices	1905:1938	These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
32600705	7	54	theme	incubation	1452:1461	arg1	30 days					1441:1447	30 days	1441:1447	30 days of incubation	1441:1461	The bioactivity of these composites was also evaluated after 30 days of incubation in a simulated body fluid solution (SBF).
32600705	9	55	theme	morphology	1671:1680	arg1	assay					1682:1686	the cellular morphology assay	1658:1686	the cellular morphology assay	1658:1686	Finally, the cell viability study and the cellular morphology assay were also carried out.
32600705	1	56	theme	passive	251:257	arg1	role					259:262	a passive role	249:262	a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue	249:501	Bone substitute materials based on bioceramics and polymers have evolved shifting from a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue.
32600705	1	57	theme	suitable	426:433	arg1	integration					435:445	suitable integration	426:445	suitable integration (osseointegration for this case)	426:478	Bone substitute materials based on bioceramics and polymers have evolved shifting from a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue.
32600705	0	58	dep	composites	43:52	arg1	composites					43:52	Antibacterial alginate/nano-hydroxyapatite composites	0:52	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.	0:160	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	0	58	dep	composites	43:52	arg1	biocompatibility					116:131	biocompatibility	116:131	biocompatibility	116:131	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	0	58	dep	composites	43:52	arg1	Assessment					83:92	Assessment	83:92	Assessment of their bioactivity	83:113	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	0	58	dep	composites	43:52	arg1	activity					152:159	antibacterial activity	138:159	antibacterial activity	138:159	Antibacterial alginate/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity.
32600705	2	59	theme	bone	699:702	arg1	regeneration					704:715	the bone regeneration	695:715	the bone regeneration	695:715	In this work, two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG) have been designed and assessed for promoting the bone regeneration.
32600705	1	60	theme	Bone	162:165	arg1	materials					178:186	Bone substitute materials	162:186	Bone substitute materials based on bioceramics and polymers	162:220	Bone substitute materials based on bioceramics and polymers have evolved shifting from a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue.
32600705	8	61	theme	antibacterial	1529:1541	arg1	capability					1543:1552	antibacterial capability	1529:1552	antibacterial capability against the three main strains cause osteomyelitis	1529:1603	Then, the assessment of antibacterial capability against the three main strains cause osteomyelitis was performed.
32600705	6	62	theme	release	1336:1342	arg1	kinetics					1344:1351	the release kinetics	1332:1351	the release kinetics of hydrogel-based systems	1332:1377	The release profile of this drug has been fit with the Ritger-Peppas model, used for studying the release kinetics of hydrogel-based systems.
32600705	3	63	theme	suitable	797:804	arg1	material					806:813	a suitable material	795:813	a suitable material for a filling but with antibacterial properties	795:861	These materials were loaded with ciprofloxacin (CIP) for obtaining, not only a suitable material for a filling but with antibacterial properties.
32600705	4	64	theme	transformed-infrared	924:943	arg1	spectroscopy					945:956	Fourier transformed-infrared spectroscopy	916:956	Fourier transformed-infrared spectroscopy (FT-IR)	916:964	Therefore, their main features were studied through Fourier transformed-infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM).
32600705	4	64	theme	transformed-infrared	924:943	arg1	FT-IR					959:963	FT-IR	959:963	FT-IR	959:963	Therefore, their main features were studied through Fourier transformed-infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM).
32600705	5	65	used	used	1172:1175	arg2	ζ-potential					1155:1165	ζ-potential	1155:1165	ζ-potential	1155:1165	Ultraviolet-Visible (UV-Vis) spectroscopy was used for obtaining the released concentrations of CIP and Zeta-potential (ζ-potential) was used for characterizing the adsorption of CIP onto nanoparticles.
32600705	5	65	used	used	1172:1175	arg2	Zeta-potential					1139:1152	Zeta-potential	1139:1152	Zeta-potential (ζ-potential)	1139:1166	Ultraviolet-Visible (UV-Vis) spectroscopy was used for obtaining the released concentrations of CIP and Zeta-potential (ζ-potential) was used for characterizing the adsorption of CIP onto nanoparticles.
32600705	8	66	theme	capability	1543:1552	arg1	assessment					1515:1524	the assessment	1511:1524	the assessment of antibacterial capability against the three main strains cause osteomyelitis	1511:1603	Then, the assessment of antibacterial capability against the three main strains cause osteomyelitis was performed.
32600705	4	67	theme	electron	1008:1015	arg1	microscopy					1017:1026	transmission electron microscopy	995:1026	transmission electron microscopy (TEM)	995:1032	Therefore, their main features were studied through Fourier transformed-infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM).
32600705	4	67	theme	electron	1008:1015	arg1	TEM					1029:1031	TEM	1029:1031	TEM	1029:1031	Therefore, their main features were studied through Fourier transformed-infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM).
32600705	5	68	theme	released	1104:1111	arg1	concentrations					1113:1126	the released concentrations	1100:1126	the released concentrations of CIP	1100:1133	Ultraviolet-Visible (UV-Vis) spectroscopy was used for obtaining the released concentrations of CIP and Zeta-potential (ζ-potential) was used for characterizing the adsorption of CIP onto nanoparticles.
34291871	8	0	theme	film	1194:1197	arg1	growth					1199:1204	the film growth	1190:1204	the film growth acquired the parabolic character	1190:1237	When pectin-Ag was substituted for the pectin in the multilayer systems, the properties of the formed coatings were significantly changed: the film rigidity and surface roughness increased, as well as the film growth acquired the parabolic character.
34291871	4	1	dep	biopolymers	556:566	arg1	biopolymers					556:566	biopolymers	556:566	biopolymers (pectin and chitosan)	556:588	In this study, multilayer films based on biopolymers (pectin and chitosan) and their nanocomposites with silver nanoparticles have been prepared and evaluated.
34291871	4	1	dep	biopolymers	556:566	arg1	chitosan					580:587	chitosan	580:587	chitosan	580:587	In this study, multilayer films based on biopolymers (pectin and chitosan) and their nanocomposites with silver nanoparticles have been prepared and evaluated.
34291871	4	1	dep	biopolymers	556:566	arg1	pectin					569:574	pectin	569:574	pectin	569:574	In this study, multilayer films based on biopolymers (pectin and chitosan) and their nanocomposites with silver nanoparticles have been prepared and evaluated.
34291871	8	2	theme	formed	1084:1089	arg1	coatings					1091:1098	the formed coatings	1080:1098	the formed coatings	1080:1098	When pectin-Ag was substituted for the pectin in the multilayer systems, the properties of the formed coatings were significantly changed: the film rigidity and surface roughness increased, as well as the film growth acquired the parabolic character.
34291871	2	3	theme	bioactive	361:369	arg1	coatings					371:378	bioactive coatings	361:378	bioactive coatings	361:378	Promising approach to overcome the problems caused by bacterial growth on the medical implants is their modification by bioactive coatings.
34291871	2	4	from	growth	305:310	arg1	implants					327:334	the medical implants	315:334	the medical implants	315:334	Promising approach to overcome the problems caused by bacterial growth on the medical implants is their modification by bioactive coatings.
34291871	8	5	theme	film	1132:1135	arg1	rigidity					1137:1144	the film rigidity	1128:1144	the film rigidity	1128:1144	When pectin-Ag was substituted for the pectin in the multilayer systems, the properties of the formed coatings were significantly changed: the film rigidity and surface roughness increased, as well as the film growth acquired the parabolic character.
34291871	0	6	with	pectin	72:77	arg1	potential					147:155	antiadhesive and bactericidal potential	117:155	antiadhesive and bactericidal potential	117:155	Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential.
34291871	1	7	theme	Implant-related	158:172	arg1	infection					174:182	Implant-related infection	158:182	Implant-related infection	158:182	Implant-related infection is one of the serious problems in regenerative medicine.
34291871	5	8	theme	dissipation	759:769	arg1	technique					771:779	dissipation technique	759:779	dissipation technique	759:779	The buildup of multilayers was monitored using the quartz crystal microbalance with dissipation technique.
34291871	4	9	theme	multilayer	530:539	arg1	films					541:545	multilayer films	530:545	multilayer films based on biopolymers (pectin and chitosan) and their nanocomposites with silver nanoparticles	530:639	In this study, multilayer films based on biopolymers (pectin and chitosan) and their nanocomposites with silver nanoparticles have been prepared and evaluated.
34291871	6	10	theme	force	846:850	arg1	microscopy					852:861	atomic force microscopy	839:861	atomic force microscopy	839:861	The morphology of the obtained films was investigated by atomic force microscopy.
34291871	2	11	theme	bacterial	295:303	arg1	growth					305:310	bacterial growth	295:310	bacterial growth on the medical implants	295:334	Promising approach to overcome the problems caused by bacterial growth on the medical implants is their modification by bioactive coatings.
34291871	12	12	theme	antiadhesive	1872:1883	arg1	behaviors					1902:1910	their antiadhesive and bactericidal behaviors	1866:1910	their antiadhesive and bactericidal behaviors	1866:1910	Our results indicate that antibacterial activity of biopolymer multilayers is determined by the film composition and physicochemical characteristics and can be associated with their antiadhesive and bactericidal behaviors.
34291871	5	13	theme	multilayers	690:700	arg1	buildup					679:685	The buildup	675:685	The buildup of multilayers	675:700	The buildup of multilayers was monitored using the quartz crystal microbalance with dissipation technique.
34291871	0	14	with	chitosan	62:69	arg1	potential					147:155	antiadhesive and bactericidal potential	117:155	antiadhesive and bactericidal potential	117:155	Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential.
34291871	12	15	theme	antibacterial	1716:1728	arg1	activity					1730:1737	antibacterial activity	1716:1737	antibacterial activity of biopolymer multilayers	1716:1763	Our results indicate that antibacterial activity of biopolymer multilayers is determined by the film composition and physicochemical characteristics and can be associated with their antiadhesive and bactericidal behaviors.
34291871	0	16	theme	silver	90:95	arg1	nanocomposites					97:110	their silver nanocomposites	84:110	their silver nanocomposites with antiadhesive and bactericidal potential	84:155	Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential.
34291871	8	17	theme	parabolic	1219:1227	arg1	character					1229:1237	the parabolic character	1215:1237	the parabolic character	1215:1237	When pectin-Ag was substituted for the pectin in the multilayer systems, the properties of the formed coatings were significantly changed: the film rigidity and surface roughness increased, as well as the film growth acquired the parabolic character.
34291871	3	18	theme	layer-by-layer	490:503	arg1	technique					393:401	A versatile technique	381:401	A versatile technique for designing multilayer films with tailored characteristics at the nanometer scale	381:485	A versatile technique for designing multilayer films with tailored characteristics at the nanometer scale is layer-by-layer assembly.
34291871	3	18	theme	layer-by-layer	490:503	arg1	assembly					505:512	layer-by-layer assembly	490:512	layer-by-layer assembly	490:512	A versatile technique for designing multilayer films with tailored characteristics at the nanometer scale is layer-by-layer assembly.
34291871	3	19	with	films	428:432	arg1	characteristics					448:462	tailored characteristics	439:462	tailored characteristics	439:462	A versatile technique for designing multilayer films with tailored characteristics at the nanometer scale is layer-by-layer assembly.
34291871	3	20	theme	multilayer	417:426	arg1	films					428:432	multilayer films	417:432	multilayer films with tailored characteristics	417:462	A versatile technique for designing multilayer films with tailored characteristics at the nanometer scale is layer-by-layer assembly.
34291871	10	21	theme	significant	1401:1411	arg1	decrease					1413:1420	The significant decrease	1397:1420	The significant decrease in the number of the adhered E. coli on the multilayer surface	1397:1483	The significant decrease in the number of the adhered E. coli on the multilayer surface has been determined; moreover, many of the cells were misshapen with cytoplasm leaking.
34291871	9	22	theme	multilayer	1253:1262	arg1	films					1264:1268	All prepared multilayer films	1240:1268	All prepared multilayer films	1240:1268	All prepared multilayer films have shown antibacterial activity against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria.
34291871	9	23	dep	gram-positive	1312:1324	arg1	aureus					1342:1347	Staphylococcus aureus	1327:1347	Staphylococcus aureus	1327:1347	All prepared multilayer films have shown antibacterial activity against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria.
34291871	7	24	theme	pectin-Ag-containing	890:909	arg1	films					911:915	pectin-Ag-containing films	890:915	pectin-Ag-containing films	890:915	We have demonstrated that pectin-Ag-containing films were characterized by the linear growth and smooth defect-free surface.
34291871	2	25	dep	approach	251:258	arg1	overcome					263:270	overcome	263:270	to overcome the problems caused by bacterial growth on the medical implants	260:334	Promising approach to overcome the problems caused by bacterial growth on the medical implants is their modification by bioactive coatings.
34291871	8	26	theme	coatings	1091:1098	arg1	properties					1066:1075	the properties	1062:1075	the properties of the formed coatings	1062:1098	When pectin-Ag was substituted for the pectin in the multilayer systems, the properties of the formed coatings were significantly changed: the film rigidity and surface roughness increased, as well as the film growth acquired the parabolic character.
34291871	2	27	theme	medical	319:325	arg1	implants					327:334	the medical implants	315:334	the medical implants	315:334	Promising approach to overcome the problems caused by bacterial growth on the medical implants is their modification by bioactive coatings.
34291871	3	28	theme	tailored	439:446	arg1	characteristics					448:462	tailored characteristics	439:462	tailored characteristics	439:462	A versatile technique for designing multilayer films with tailored characteristics at the nanometer scale is layer-by-layer assembly.
34291871	0	29	theme	Physicochemical	0:14	arg1	aspects					16:22	Physicochemical aspects	0:22	Physicochemical aspects of design of ultrathin films	0:51	Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential.
34291871	10	30	from	number	1429:1434	arg1	surface					1477:1483	the multilayer surface	1462:1483	the multilayer surface	1462:1483	The significant decrease in the number of the adhered E. coli on the multilayer surface has been determined; moreover, many of the cells were misshapen with cytoplasm leaking.
34291871	12	31	theme	film	1786:1789	arg1	composition					1791:1801	the film composition	1782:1801	the film composition	1782:1801	Our results indicate that antibacterial activity of biopolymer multilayers is determined by the film composition and physicochemical characteristics and can be associated with their antiadhesive and bactericidal behaviors.
34291871	10	32	theme	multilayer	1466:1475	arg1	surface					1477:1483	the multilayer surface	1462:1483	the multilayer surface	1462:1483	The significant decrease in the number of the adhered E. coli on the multilayer surface has been determined; moreover, many of the cells were misshapen with cytoplasm leaking.
34291871	4	33	with	biopolymers	556:566	arg1	nanoparticles					627:639	silver nanoparticles	620:639	silver nanoparticles	620:639	In this study, multilayer films based on biopolymers (pectin and chitosan) and their nanocomposites with silver nanoparticles have been prepared and evaluated.
34291871	10	34	from	decrease	1413:1420	arg1	number					1429:1434	the number	1425:1434	the number of the adhered E. coli on the multilayer surface	1425:1483	The significant decrease in the number of the adhered E. coli on the multilayer surface has been determined; moreover, many of the cells were misshapen with cytoplasm leaking.
34291871	0	35	theme	design	27:32	arg1	aspects					16:22	Physicochemical aspects	0:22	Physicochemical aspects of design of ultrathin films	0:51	Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential.
34291871	10	36	theme	cells	1528:1532	arg1	many					1516:1519	many	1516:1519	many	1516:1519	The significant decrease in the number of the adhered E. coli on the multilayer surface has been determined; moreover, many of the cells were misshapen with cytoplasm leaking.
34291871	10	36	theme	cells	1528:1532	arg1	cells					1528:1532	the cells	1524:1532	the cells	1524:1532	The significant decrease in the number of the adhered E. coli on the multilayer surface has been determined; moreover, many of the cells were misshapen with cytoplasm leaking.
34291871	5	37	theme	quartz	726:731	arg1	microbalance					741:752	the quartz crystal microbalance	722:752	the quartz crystal microbalance with dissipation technique	722:779	The buildup of multilayers was monitored using the quartz crystal microbalance with dissipation technique.
34291871	6	38	theme	films	813:817	arg1	morphology					786:795	The morphology	782:795	The morphology of the obtained films	782:817	The morphology of the obtained films was investigated by atomic force microscopy.
34291871	5	39	with	microbalance	741:752	arg1	technique					771:779	dissipation technique	759:779	dissipation technique	759:779	The buildup of multilayers was monitored using the quartz crystal microbalance with dissipation technique.
34291871	3	40	theme	versatile	383:391	arg1	technique					393:401	A versatile technique	381:401	A versatile technique for designing multilayer films with tailored characteristics at the nanometer scale	381:485	A versatile technique for designing multilayer films with tailored characteristics at the nanometer scale is layer-by-layer assembly.
34291871	3	40	theme	versatile	383:391	arg1	assembly					505:512	layer-by-layer assembly	490:512	layer-by-layer assembly	490:512	A versatile technique for designing multilayer films with tailored characteristics at the nanometer scale is layer-by-layer assembly.
34291871	5	41	theme	crystal	733:739	arg1	microbalance					741:752	the quartz crystal microbalance	722:752	the quartz crystal microbalance with dissipation technique	722:779	The buildup of multilayers was monitored using the quartz crystal microbalance with dissipation technique.
34291871	9	42	theme	antibacterial	1281:1293	arg1	activity					1295:1302	antibacterial activity	1281:1302	antibacterial activity against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria	1281:1394	All prepared multilayer films have shown antibacterial activity against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria.
34291871	10	43	from	surface	1477:1483	arg1	number					1429:1434	the number	1425:1434	the number of the adhered E. coli on the multilayer surface	1425:1483	The significant decrease in the number of the adhered E. coli on the multilayer surface has been determined; moreover, many of the cells were misshapen with cytoplasm leaking.
34291871	1	44	theme	serious	198:204	arg1	problems					206:213	the serious problems	194:213	the serious problems in regenerative medicine	194:238	Implant-related infection is one of the serious problems in regenerative medicine.
34291871	0	45	theme	ultrathin	37:45	arg1	films					47:51	ultrathin films	37:51	ultrathin films	37:51	Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential.
34291871	8	46	theme	surface	1150:1156	arg1	roughness					1158:1166	surface roughness	1150:1166	surface roughness	1150:1166	When pectin-Ag was substituted for the pectin in the multilayer systems, the properties of the formed coatings were significantly changed: the film rigidity and surface roughness increased, as well as the film growth acquired the parabolic character.
34291871	3	47	theme	nanometer	471:479	arg1	scale					481:485	the nanometer scale	467:485	the nanometer scale	467:485	A versatile technique for designing multilayer films with tailored characteristics at the nanometer scale is layer-by-layer assembly.
34291871	2	48	theme	Promising	241:249	arg1	approach					251:258	Promising approach	241:258	Promising approach to overcome the problems caused by bacterial growth on the medical implants	241:334	Promising approach to overcome the problems caused by bacterial growth on the medical implants is their modification by bioactive coatings.
34291871	7	49	theme	smooth	961:966	arg1	surface					980:986	smooth defect-free surface	961:986	smooth defect-free surface	961:986	We have demonstrated that pectin-Ag-containing films were characterized by the linear growth and smooth defect-free surface.
34291871	1	50	theme	problems	206:213	arg1	one					187:189	one	187:189	one	187:189	Implant-related infection is one of the serious problems in regenerative medicine.
34291871	1	50	theme	problems	206:213	arg1	problems					206:213	the serious problems	194:213	the serious problems in regenerative medicine	194:238	Implant-related infection is one of the serious problems in regenerative medicine.
34291871	12	51	theme	multilayers	1753:1763	arg1	activity					1730:1737	antibacterial activity	1716:1737	antibacterial activity of biopolymer multilayers	1716:1763	Our results indicate that antibacterial activity of biopolymer multilayers is determined by the film composition and physicochemical characteristics and can be associated with their antiadhesive and bactericidal behaviors.
34291871	9	52	dep	bacteria	1387:1394	arg1	coli					1381:1384	Escherichia coli	1369:1384	Escherichia coli	1369:1384	All prepared multilayer films have shown antibacterial activity against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria.
34291871	0	53	theme	antiadhesive	117:128	arg1	potential					147:155	antiadhesive and bactericidal potential	117:155	antiadhesive and bactericidal potential	117:155	Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential.
34291871	6	54	theme	obtained	804:811	arg1	films					813:817	the obtained films	800:817	the obtained films	800:817	The morphology of the obtained films was investigated by atomic force microscopy.
34291871	1	55	from	problems	206:213	arg1	medicine					231:238	regenerative medicine	218:238	regenerative medicine	218:238	Implant-related infection is one of the serious problems in regenerative medicine.
34291871	9	56	theme	prepared	1244:1251	arg1	films					1264:1268	All prepared multilayer films	1240:1268	All prepared multilayer films	1240:1268	All prepared multilayer films have shown antibacterial activity against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria.
34291871	0	57	theme	films	47:51	arg1	design					27:32	design	27:32	design of ultrathin films	27:51	Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential.
34291871	0	58	theme	bactericidal	134:145	arg1	potential					147:155	antiadhesive and bactericidal potential	117:155	antiadhesive and bactericidal potential	117:155	Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential.
34291871	12	59	theme	biopolymer	1742:1751	arg1	multilayers					1753:1763	biopolymer multilayers	1742:1763	biopolymer multilayers	1742:1763	Our results indicate that antibacterial activity of biopolymer multilayers is determined by the film composition and physicochemical characteristics and can be associated with their antiadhesive and bactericidal behaviors.
34291871	9	60	theme	gram-negative	1354:1366	arg1	bacteria					1387:1394	gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria	1312:1394	bacteria	1387:1394	All prepared multilayer films have shown antibacterial activity against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria.
34291871	7	61	theme	defect-free	968:978	arg1	surface					980:986	smooth defect-free surface	961:986	smooth defect-free surface	961:986	We have demonstrated that pectin-Ag-containing films were characterized by the linear growth and smooth defect-free surface.
34291871	11	62	theme	mild	1612:1615	arg1	activity					1617:1624	a mild activity	1610:1624	a mild activity against S. aureus	1610:1642	The prepared multilayer films showed a mild activity against S. aureus predominantly due to the antiadhesive effect.
34291871	10	63	theme	leaking	1564:1570	arg1	cytoplasm					1554:1562	cytoplasm leaking	1554:1570	cytoplasm leaking	1554:1570	The significant decrease in the number of the adhered E. coli on the multilayer surface has been determined; moreover, many of the cells were misshapen with cytoplasm leaking.
34291871	12	64	theme	physicochemical	1807:1821	arg1	characteristics					1823:1837	physicochemical characteristics	1807:1837	physicochemical characteristics	1807:1837	Our results indicate that antibacterial activity of biopolymer multilayers is determined by the film composition and physicochemical characteristics and can be associated with their antiadhesive and bactericidal behaviors.
34291871	11	65	theme	prepared	1577:1584	arg1	films					1597:1601	The prepared multilayer films	1573:1601	The prepared multilayer films	1573:1601	The prepared multilayer films showed a mild activity against S. aureus predominantly due to the antiadhesive effect.
34291871	10	66	theme	coli	1454:1457	arg1	number					1429:1434	the number	1425:1434	the number of the adhered E. coli on the multilayer surface	1425:1483	The significant decrease in the number of the adhered E. coli on the multilayer surface has been determined; moreover, many of the cells were misshapen with cytoplasm leaking.
34291871	8	67	theme	multilayer	1042:1051	arg1	systems					1053:1059	the multilayer systems	1038:1059	the multilayer systems	1038:1059	When pectin-Ag was substituted for the pectin in the multilayer systems, the properties of the formed coatings were significantly changed: the film rigidity and surface roughness increased, as well as the film growth acquired the parabolic character.
34291871	1	68	theme	regenerative	218:229	arg1	medicine					231:238	regenerative medicine	218:238	regenerative medicine	218:238	Implant-related infection is one of the serious problems in regenerative medicine.
34291871	4	69	with	nanocomposites	600:613	arg1	nanoparticles					627:639	silver nanoparticles	620:639	silver nanoparticles	620:639	In this study, multilayer films based on biopolymers (pectin and chitosan) and their nanocomposites with silver nanoparticles have been prepared and evaluated.
34291871	11	70	theme	antiadhesive	1669:1680	arg1	effect					1682:1687	the antiadhesive effect	1665:1687	the antiadhesive effect	1665:1687	The prepared multilayer films showed a mild activity against S. aureus predominantly due to the antiadhesive effect.
34291871	6	71	theme	atomic	839:844	arg1	microscopy					852:861	atomic force microscopy	839:861	atomic force microscopy	839:861	The morphology of the obtained films was investigated by atomic force microscopy.
34291871	4	72	theme	silver	620:625	arg1	nanoparticles					627:639	silver nanoparticles	620:639	silver nanoparticles	620:639	In this study, multilayer films based on biopolymers (pectin and chitosan) and their nanocomposites with silver nanoparticles have been prepared and evaluated.
34291871	8	73	from	pectin	1028:1033	arg1	systems					1053:1059	the multilayer systems	1038:1059	the multilayer systems	1038:1059	When pectin-Ag was substituted for the pectin in the multilayer systems, the properties of the formed coatings were significantly changed: the film rigidity and surface roughness increased, as well as the film growth acquired the parabolic character.
34291871	0	74	with	nanocomposites	97:110	arg1	potential					147:155	antiadhesive and bactericidal potential	117:155	antiadhesive and bactericidal potential	117:155	Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential.
34291871	12	75	theme	bactericidal	1889:1900	arg1	behaviors					1902:1910	their antiadhesive and bactericidal behaviors	1866:1910	their antiadhesive and bactericidal behaviors	1866:1910	Our results indicate that antibacterial activity of biopolymer multilayers is determined by the film composition and physicochemical characteristics and can be associated with their antiadhesive and bactericidal behaviors.
34291871	7	76	theme	linear	943:948	arg1	growth					950:955	the linear growth	939:955	the linear growth	939:955	We have demonstrated that pectin-Ag-containing films were characterized by the linear growth and smooth defect-free surface.
34291871	11	77	theme	multilayer	1586:1595	arg1	films					1597:1601	The prepared multilayer films	1573:1601	The prepared multilayer films	1573:1601	The prepared multilayer films showed a mild activity against S. aureus predominantly due to the antiadhesive effect.
33662819	3	0	theme	Sprague-Dawley	731:744	arg1	rats					746:749	Sprague-Dawley rats	731:749	Sprague-Dawley rats	731:749	Composite patches were sutured to the ventricular surface of ischemic myocardium in Sprague-Dawley rats, and the resulting angiogenic response was followed for 28 days.
33662819	7	1	theme	myocardial	1575:1584	arg1	remodeling					1586:1595	ischemic myocardial remodeling	1566:1595	ischemic myocardial remodeling	1566:1595	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	2	2	theme	silk	636:639	arg1	mesh					641:644	a reinforcing silk mesh	622:644	a reinforcing silk mesh	622:644	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	3	3	theme	angiogenic	770:779	arg1	response					781:788	the resulting angiogenic response	756:788	the resulting angiogenic response	756:788	Composite patches were sutured to the ventricular surface of ischemic myocardium in Sprague-Dawley rats, and the resulting angiogenic response was followed for 28 days.
33662819	6	4	theme	macrophages	1343:1353	arg1	density					1268:1274	the density	1264:1274	the density of elicited mast cells and both CD68+ and anti-inflammatory CD163+ macrophages	1264:1353	In addition, growth factor delivery reduced cell apoptosis and decreased the density of elicited mast cells and both CD68+ and anti-inflammatory CD163+ macrophages.
33662819	1	5	theme	histologic	298:307	arg1	responses					309:317	advantageous histologic responses	285:317	advantageous histologic responses when secured to ischemic myocardium	285:353	In this project, the ability of dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels to elicit advantageous histologic responses when secured to ischemic myocardium was evaluated in vivo.
33662819	3	6	from	surface	697:703	arg1	rats					746:749	Sprague-Dawley rats	731:749	Sprague-Dawley rats	731:749	Composite patches were sutured to the ventricular surface of ischemic myocardium in Sprague-Dawley rats, and the resulting angiogenic response was followed for 28 days.
33662819	6	7	theme	anti-inflammatory	1318:1334	arg1	macrophages					1343:1353	both CD68+ and anti-inflammatory CD163+ macrophages	1303:1353	both CD68+ and anti-inflammatory CD163+ macrophages	1303:1353	In addition, growth factor delivery reduced cell apoptosis and decreased the density of elicited mast cells and both CD68+ and anti-inflammatory CD163+ macrophages.
33662819	7	8	theme	therapeutic	1539:1549	arg1	improvement					1551:1561	therapeutic improvement	1539:1561	therapeutic improvement of ischemic myocardial remodeling	1539:1595	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	6	9	theme	CD68+	1308:1312	arg1	macrophages					1343:1353	both CD68+ and anti-inflammatory CD163+ macrophages	1303:1353	both CD68+ and anti-inflammatory CD163+ macrophages	1303:1353	In addition, growth factor delivery reduced cell apoptosis and decreased the density of elicited mast cells and both CD68+ and anti-inflammatory CD163+ macrophages.
33662819	6	10	theme	factor	1211:1216	arg1	delivery					1218:1225	growth factor delivery	1204:1225	growth factor delivery	1204:1225	In addition, growth factor delivery reduced cell apoptosis and decreased the density of elicited mast cells and both CD68+ and anti-inflammatory CD163+ macrophages.
33662819	0	11	theme	glycosaminoglycan	125:141	arg1	hydrogels					143:151	composite glycosaminoglycan hydrogels	115:151	composite glycosaminoglycan hydrogels	115:151	Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.
33662819	5	12	theme	infarcted	1151:1159	arg1	tissue					1172:1177	infarcted myocardial tissue (p < 0.05)	1151:1188	infarcted myocardial tissue (p < 0.05)	1151:1188	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	5	12	theme	infarcted	1151:1159	arg1	<					1182:1182	p < 0.05	1180:1187	p < 0.05	1180:1187	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	7	13	theme	beneficial	1466:1475	arg1	responses					1477:1485	beneficial responses	1466:1485	beneficial responses in ischemic myocardium	1466:1508	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	3	14	from	rats	746:749	arg1	surface					697:703	the ventricular surface	681:703	the ventricular surface of ischemic myocardium in Sprague-Dawley rats	681:749	Composite patches were sutured to the ventricular surface of ischemic myocardium in Sprague-Dawley rats, and the resulting angiogenic response was followed for 28 days.
33662819	4	15	dep	showed	855:860	arg1	reduced					876:882	reduced	876:882	showed significantly reduced ischemic area and fibrous deposition compared to untreated control hearts	855:956	The gross appearance of treated hearts showed significantly reduced ischemic area and fibrous deposition compared to untreated control hearts.
33662819	6	16	theme	cells	1293:1297	arg1	density					1268:1274	the density	1264:1274	the density of elicited mast cells and both CD68+ and anti-inflammatory CD163+ macrophages	1264:1353	In addition, growth factor delivery reduced cell apoptosis and decreased the density of elicited mast cells and both CD68+ and anti-inflammatory CD163+ macrophages.
33662819	5	17	theme	growth	988:993	arg1	factor					995:1000	growth factor	988:1000	growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05)	988:1188	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	6	18	theme	elicited	1279:1286	arg1	cells					1293:1297	elicited mast cells	1279:1297	elicited mast cells	1279:1297	In addition, growth factor delivery reduced cell apoptosis and decreased the density of elicited mast cells and both CD68+ and anti-inflammatory CD163+ macrophages.
33662819	7	19	from	myocardium	1499:1508	arg1	series					1456:1461	a series	1454:1461	a series of beneficial responses in ischemic myocardium	1454:1508	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	2	20	theme	hyaluronic	549:558	arg1	acid					560:563	chemically modified hyaluronic acid	529:563	chemically modified hyaluronic acid	529:563	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	0	21	theme	dual	82:85	arg1	factor					94:99	dual growth factor	82:99	dual growth factor delivery from composite glycosaminoglycan hydrogels	82:151	Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.
33662819	2	22	theme	reinforcing	624:634	arg1	mesh					641:644	a reinforcing silk mesh	622:644	a reinforcing silk mesh	622:644	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	0	23	theme	factor	94:99	arg1	delivery					101:108	dual growth factor delivery	82:108	dual growth factor delivery from composite glycosaminoglycan hydrogels	82:151	Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.
33662819	5	24	theme	p	1180:1180	arg1	tissue					1172:1177	infarcted myocardial tissue (p < 0.05)	1151:1188	infarcted myocardial tissue (p < 0.05)	1151:1188	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	5	24	theme	p	1180:1180	arg1	<					1182:1182	p < 0.05	1180:1187	p < 0.05	1180:1187	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	5	25	theme	pre-surgical	1046:1057	arg1	levels					1059:1064	pre-surgical levels	1046:1064	pre-surgical levels	1046:1064	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	4	26	theme	gross	820:824	arg1	appearance					826:835	The gross appearance	816:835	The gross appearance of treated hearts	816:853	The gross appearance of treated hearts showed significantly reduced ischemic area and fibrous deposition compared to untreated control hearts.
33662819	0	27	from	responses	37:45	arg1	myocardium					59:68	ischemic myocardium	50:68	ischemic myocardium	50:68	Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.
33662819	2	28	theme	Growth	436:441	arg1	Factor					443:448	Vascular Endothelial Growth Factor	415:448	Vascular Endothelial Growth Factor (VEGF)	415:455	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	2	28	theme	Growth	436:441	arg1	VEGF					451:454	VEGF	451:454	VEGF	451:454	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	0	29	theme	Histologic	0:9	arg1	evaluation					11:20	Histologic evaluation	0:20	Histologic evaluation of therapeutic responses in ischemic myocardium	0:68	Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.
33662819	7	30	from	series	1456:1461	arg1	myocardium					1499:1508	ischemic myocardium	1490:1508	ischemic myocardium	1490:1508	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	7	31	theme	growth	1399:1404	arg1	hydrogels					1420:1428	HA-based, dual growth factor-loaded hydrogels	1384:1428	HA-based, dual growth factor-loaded hydrogels	1384:1428	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	2	32	theme	Platelet-derived	461:476	arg1	PDGF					493:496	PDGF	493:496	PDGF	493:496	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	2	32	theme	Platelet-derived	461:476	arg1	Factor					485:490	Platelet-derived Growth Factor	461:490	Platelet-derived Growth Factor (PDGF)	461:497	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	0	33	theme	responses	37:45	arg1	evaluation					11:20	Histologic evaluation	0:20	Histologic evaluation of therapeutic responses in ischemic myocardium	0:68	Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.
33662819	1	34	theme	ischemic	335:342	arg1	myocardium					344:353	ischemic myocardium	335:353	ischemic myocardium	335:353	In this project, the ability of dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels to elicit advantageous histologic responses when secured to ischemic myocardium was evaluated in vivo.
33662819	4	35	theme	control	943:949	arg1	hearts					951:956	untreated control hearts	933:956	untreated control hearts	933:956	The gross appearance of treated hearts showed significantly reduced ischemic area and fibrous deposition compared to untreated control hearts.
33662819	4	36	theme	ischemic	884:891	arg1	area					893:896	ischemic area	884:896	ischemic area	884:896	The gross appearance of treated hearts showed significantly reduced ischemic area and fibrous deposition compared to untreated control hearts.
33662819	2	37	theme	Reinforced	378:387	arg1	hydrogels					389:397	Reinforced hydrogels	378:397	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF)	378:497	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	0	38	theme	ischemic	50:57	arg1	myocardium					59:68	ischemic myocardium	50:68	ischemic myocardium	50:68	Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.
33662819	3	39	theme	ischemic	708:715	arg1	myocardium					717:726	ischemic myocardium	708:726	ischemic myocardium in Sprague-Dawley rats	708:749	Composite patches were sutured to the ventricular surface of ischemic myocardium in Sprague-Dawley rats, and the resulting angiogenic response was followed for 28 days.
33662819	4	40	theme	hearts	848:853	arg1	appearance					826:835	The gross appearance	816:835	The gross appearance of treated hearts	816:853	The gross appearance of treated hearts showed significantly reduced ischemic area and fibrous deposition compared to untreated control hearts.
33662819	2	41	theme	Vascular	415:422	arg1	Factor					443:448	Vascular Endothelial Growth Factor	415:448	Vascular Endothelial Growth Factor (VEGF)	415:455	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	2	41	theme	Vascular	415:422	arg1	VEGF					451:454	VEGF	451:454	VEGF	451:454	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	1	42	theme	acid-based	254:263	arg1	hydrogels					265:273	dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels	186:273	dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels	186:273	In this project, the ability of dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels to elicit advantageous histologic responses when secured to ischemic myocardium was evaluated in vivo.
33662819	7	43	theme	remodeling	1586:1595	arg1	improvement					1551:1561	therapeutic improvement	1539:1561	therapeutic improvement of ischemic myocardial remodeling	1539:1595	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	5	44	theme	elicited	1096:1103	arg1	density					1117:1123	elicited microvessel density	1096:1123	elicited microvessel density	1096:1123	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	3	45	from	myocardium	717:726	arg1	rats					746:749	Sprague-Dawley rats	731:749	Sprague-Dawley rats	731:749	Composite patches were sutured to the ventricular surface of ischemic myocardium in Sprague-Dawley rats, and the resulting angiogenic response was followed for 28 days.
33662819	7	46	theme	ischemic	1566:1573	arg1	remodeling					1586:1595	ischemic myocardial remodeling	1566:1595	ischemic myocardial remodeling	1566:1595	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	1	47	dep	ability	175:181	arg1	elicit					278:283	elicit	278:283	to elicit advantageous histologic responses when secured to ischemic myocardium	275:353	In this project, the ability of dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels to elicit advantageous histologic responses when secured to ischemic myocardium was evaluated in vivo.
33662819	1	48	theme	advantageous	285:296	arg1	responses					309:317	advantageous histologic responses	285:317	advantageous histologic responses when secured to ischemic myocardium	285:353	In this project, the ability of dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels to elicit advantageous histologic responses when secured to ischemic myocardium was evaluated in vivo.
33662819	4	49	theme	untreated	933:941	arg1	hearts					951:956	untreated control hearts	933:956	untreated control hearts	933:956	The gross appearance of treated hearts showed significantly reduced ischemic area and fibrous deposition compared to untreated control hearts.
33662819	6	50	theme	CD163+	1336:1341	arg1	macrophages					1343:1353	both CD68+ and anti-inflammatory CD163+ macrophages	1303:1353	both CD68+ and anti-inflammatory CD163+ macrophages	1303:1353	In addition, growth factor delivery reduced cell apoptosis and decreased the density of elicited mast cells and both CD68+ and anti-inflammatory CD163+ macrophages.
33662819	6	51	theme	cell	1235:1238	arg1	apoptosis					1240:1248	cell apoptosis	1235:1248	cell apoptosis	1235:1248	In addition, growth factor delivery reduced cell apoptosis and decreased the density of elicited mast cells and both CD68+ and anti-inflammatory CD163+ macrophages.
33662819	3	52	theme	resulting	760:768	arg1	response					781:788	the resulting angiogenic response	756:788	the resulting angiogenic response	756:788	Composite patches were sutured to the ventricular surface of ischemic myocardium in Sprague-Dawley rats, and the resulting angiogenic response was followed for 28 days.
33662819	1	53	theme	dual	186:189	arg1	hydrogels					265:273	dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels	186:273	dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels	186:273	In this project, the ability of dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels to elicit advantageous histologic responses when secured to ischemic myocardium was evaluated in vivo.
33662819	4	54	theme	fibrous	902:908	arg1	deposition					910:919	fibrous deposition	902:919	fibrous deposition	902:919	The gross appearance of treated hearts showed significantly reduced ischemic area and fibrous deposition compared to untreated control hearts.
33662819	5	55	from	maturity	1129:1136	arg1	tissue					1172:1177	infarcted myocardial tissue (p < 0.05)	1151:1188	infarcted myocardial tissue (p < 0.05)	1151:1188	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	5	55	from	maturity	1129:1136	arg1	<					1182:1182	p < 0.05	1180:1187	p < 0.05	1180:1187	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	1	56	theme	factor-preloaded	198:213	arg1	hydrogels					265:273	dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels	186:273	dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels	186:273	In this project, the ability of dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels to elicit advantageous histologic responses when secured to ischemic myocardium was evaluated in vivo.
33662819	2	57	theme	ethylene	587:594	arg1	poly					582:585	poly	582:585	poly(ethylene glycol)-diacrylate around a reinforcing silk mesh	582:644	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	2	57	theme	ethylene	587:594	arg1	glycol					596:601	ethylene glycol	587:601	ethylene glycol	587:601	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	7	58	theme	ischemic	1490:1497	arg1	myocardium					1499:1508	ischemic myocardium	1490:1508	ischemic myocardium	1490:1508	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	5	59	theme	myocardial	1161:1170	arg1	tissue					1172:1177	infarcted myocardial tissue (p < 0.05)	1151:1188	infarcted myocardial tissue (p < 0.05)	1151:1188	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	5	59	theme	myocardial	1161:1170	arg1	<					1182:1182	p < 0.05	1180:1187	p < 0.05	1180:1187	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	5	60	from	density	1117:1123	arg1	tissue					1172:1177	infarcted myocardial tissue (p < 0.05)	1151:1188	infarcted myocardial tissue (p < 0.05)	1151:1188	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	5	60	from	density	1117:1123	arg1	<					1182:1182	p < 0.05	1180:1187	p < 0.05	1180:1187	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	2	61	theme	poly	582:585	arg1	-diacrylate					603:613	poly(ethylene glycol)-diacrylate	582:613	poly(ethylene glycol)-diacrylate around a reinforcing silk mesh	582:644	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	7	62	theme	responses	1477:1485	arg1	series					1456:1461	a series	1454:1461	a series of beneficial responses in ischemic myocardium	1454:1508	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	6	63	theme	mast	1288:1291	arg1	cells					1293:1297	elicited mast cells	1279:1297	elicited mast cells	1279:1297	In addition, growth factor delivery reduced cell apoptosis and decreased the density of elicited mast cells and both CD68+ and anti-inflammatory CD163+ macrophages.
33662819	5	64	theme	factor	995:1000	arg1	delivery					1002:1009	growth factor delivery	988:1009	growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05)	988:1188	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	3	65	theme	Composite	647:655	arg1	patches					657:663	Composite patches	647:663	Composite patches	647:663	Composite patches were sutured to the ventricular surface of ischemic myocardium in Sprague-Dawley rats, and the resulting angiogenic response was followed for 28 days.
33662819	2	66	theme	modified	540:547	arg1	acid					560:563	chemically modified hyaluronic acid	529:563	chemically modified hyaluronic acid	529:563	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	0	67	theme	growth	87:92	arg1	factor					94:99	dual growth factor	82:99	dual growth factor delivery from composite glycosaminoglycan hydrogels	82:151	Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.
33662819	5	68	theme	Histologic	959:968	arg1	evaluation					970:979	Histologic evaluation	959:979	Histologic evaluation	959:979	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	0	69	from	evaluation	11:20	arg1	myocardium					59:68	ischemic myocardium	50:68	ischemic myocardium	50:68	Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.
33662819	6	70	theme	growth	1204:1209	arg1	factor					1211:1216	growth factor	1204:1216	growth factor delivery	1204:1225	In addition, growth factor delivery reduced cell apoptosis and decreased the density of elicited mast cells and both CD68+ and anti-inflammatory CD163+ macrophages.
33662819	0	71	from	myocardium	59:68	arg1	evaluation					11:20	Histologic evaluation	0:20	Histologic evaluation of therapeutic responses in ischemic myocardium	0:68	Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.
33662819	5	72	dep	delivery	1002:1009	arg1	increase					1087:1094	increase	1087:1094	to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05)	1070:1188	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	5	72	dep	delivery	1002:1009	arg1	restore					1014:1020	restore	1014:1020	to restore myofiber orientation to pre-surgical levels	1011:1064	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	0	73	theme	composite	115:123	arg1	hydrogels					143:151	composite glycosaminoglycan hydrogels	115:151	composite glycosaminoglycan hydrogels	115:151	Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.
33662819	2	74	contain	containing	399:408	arg2	VEGF					451:454	VEGF	451:454	VEGF	451:454	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	2	74	contain	containing	399:408	arg2	PDGF					493:496	PDGF	493:496	PDGF	493:496	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	2	74	contain	containing	399:408	arg2	Factor					485:490	Platelet-derived Growth Factor	461:490	Platelet-derived Growth Factor (PDGF)	461:497	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	2	74	contain	containing	399:408	arg1	hydrogels					389:397	Reinforced hydrogels	378:397	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF)	378:497	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	2	74	contain	containing	399:408	arg2	Factor					443:448	Vascular Endothelial Growth Factor	415:448	Vascular Endothelial Growth Factor (VEGF)	415:455	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	7	75	theme	factor-loaded	1406:1418	arg1	hydrogels					1420:1428	HA-based, dual growth factor-loaded hydrogels	1384:1428	HA-based, dual growth factor-loaded hydrogels	1384:1428	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	2	76	theme	Endothelial	424:434	arg1	Factor					443:448	Vascular Endothelial Growth Factor	415:448	Vascular Endothelial Growth Factor (VEGF)	415:455	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	2	76	theme	Endothelial	424:434	arg1	VEGF					451:454	VEGF	451:454	VEGF	451:454	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	0	77	theme	therapeutic	25:35	arg1	responses					37:45	therapeutic responses	25:45	therapeutic responses in ischemic myocardium	25:68	Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.
33662819	1	78	dep	factor-preloaded	198:213	arg1	composite					233:241	composite	233:241	composite	233:241	In this project, the ability of dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels to elicit advantageous histologic responses when secured to ischemic myocardium was evaluated in vivo.
33662819	1	78	dep	factor-preloaded	198:213	arg1	silk-reinforced					216:230	silk-reinforced	216:230	silk-reinforced	216:230	In this project, the ability of dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels to elicit advantageous histologic responses when secured to ischemic myocardium was evaluated in vivo.
33662819	5	79	theme	myofiber	1022:1029	arg1	orientation					1031:1041	myofiber orientation	1022:1041	myofiber orientation	1022:1041	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	7	80	theme	HA-based	1384:1391	arg1	hydrogels					1420:1428	HA-based, dual growth factor-loaded hydrogels	1384:1428	HA-based, dual growth factor-loaded hydrogels	1384:1428	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	2	81	theme	Growth	478:483	arg1	PDGF					493:496	PDGF	493:496	PDGF	493:496	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	2	81	theme	Growth	478:483	arg1	Factor					485:490	Platelet-derived Growth Factor	461:490	Platelet-derived Growth Factor (PDGF)	461:497	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	3	82	theme	ventricular	685:695	arg1	surface					697:703	the ventricular surface	681:703	the ventricular surface of ischemic myocardium in Sprague-Dawley rats	681:749	Composite patches were sutured to the ventricular surface of ischemic myocardium in Sprague-Dawley rats, and the resulting angiogenic response was followed for 28 days.
33662819	5	83	theme	microvessel	1105:1115	arg1	density					1117:1123	elicited microvessel density	1096:1123	elicited microvessel density	1096:1123	Histologic evaluation showed growth factor delivery to restore myofiber orientation to pre-surgical levels and to significantly increase elicited microvessel density and maturity by day 28 in infarcted myocardial tissue (p < 0.05).
33662819	7	84	from	responses	1477:1485	arg1	myocardium					1499:1508	ischemic myocardium	1490:1508	ischemic myocardium	1490:1508	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	3	85	theme	myocardium	717:726	arg1	surface					697:703	the ventricular surface	681:703	the ventricular surface of ischemic myocardium in Sprague-Dawley rats	681:749	Composite patches were sutured to the ventricular surface of ischemic myocardium in Sprague-Dawley rats, and the resulting angiogenic response was followed for 28 days.
33662819	2	86	link	Platelet-derived	461:476	arg1	PDGF					493:496	PDGF	493:496	PDGF	493:496	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	2	86	link	Platelet-derived	461:476	arg1	Factor					485:490	Platelet-derived Growth Factor	461:490	Platelet-derived Growth Factor (PDGF)	461:497	Reinforced hydrogels containing both Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF) were prepared by crosslinking chemically modified hyaluronic acid and heparin with poly(ethylene glycol)-diacrylate around a reinforcing silk mesh.
33662819	1	87	theme	hyaluronic	243:252	arg1	hydrogels					265:273	dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels	186:273	dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels	186:273	In this project, the ability of dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels to elicit advantageous histologic responses when secured to ischemic myocardium was evaluated in vivo.
33662819	7	88	dep	HA-based	1384:1391	arg1	dual					1394:1397	dual	1394:1397	dual	1394:1397	These findings suggest that HA-based, dual growth factor-loaded hydrogels can successfully induce a series of beneficial responses in ischemic myocardium, and offer the potential for therapeutic improvement of ischemic myocardial remodeling.
33662819	0	89	from	hydrogels	143:151	arg1	delivery					101:108	dual growth factor delivery	82:108	dual growth factor delivery from composite glycosaminoglycan hydrogels	82:151	Histologic evaluation of therapeutic responses in ischemic myocardium elicited by dual growth factor delivery from composite glycosaminoglycan hydrogels.
33662819	4	90	theme	treated	840:846	arg1	hearts					848:853	treated hearts	840:853	treated hearts	840:853	The gross appearance of treated hearts showed significantly reduced ischemic area and fibrous deposition compared to untreated control hearts.
33662819	1	91	theme	hydrogels	265:273	arg1	ability					175:181	the ability	171:181	the ability of dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels to elicit advantageous histologic responses when secured to ischemic myocardium	171:353	In this project, the ability of dual growth factor-preloaded, silk-reinforced, composite hyaluronic acid-based hydrogels to elicit advantageous histologic responses when secured to ischemic myocardium was evaluated in vivo.
34954358	0	0	theme	hydrolysis	82:91	arg1	performance					93:103	enzymatic hydrolysis performance	72:103	enzymatic hydrolysis performance	72:103	Multifactorial effects of gluconic acid pretreatment of waste straws on enzymatic hydrolysis performance.
34954358	6	1	theme	nonlinear	958:966	arg1	models					968:973	Both linear and nonlinear models	942:973	Both linear and nonlinear models	942:973	Both linear and nonlinear models were compared using five-parameter logic curve, four-parameter logic curve, and Deming regression.
34954358	1	2	theme	cellulose	161:169	arg1	compositions					119:130	The chemical compositions	106:130	The chemical compositions of lignin, hemicellulose and cellulose	106:169	The chemical compositions of lignin, hemicellulose and cellulose are so far unascertained to various lignocellulose in respect to effect of cellulose enzymatic hydrolysis.
34954358	1	3	theme	enzymatic	256:264	arg1	hydrolysis					266:275	cellulose enzymatic hydrolysis	246:275	cellulose enzymatic hydrolysis	246:275	The chemical compositions of lignin, hemicellulose and cellulose are so far unascertained to various lignocellulose in respect to effect of cellulose enzymatic hydrolysis.
34954358	0	4	theme	enzymatic	72:80	arg1	performance					93:103	enzymatic hydrolysis performance	72:103	enzymatic hydrolysis performance	72:103	Multifactorial effects of gluconic acid pretreatment of waste straws on enzymatic hydrolysis performance.
34954358	0	5	from	effects	15:21	arg1	performance					93:103	enzymatic hydrolysis performance	72:103	enzymatic hydrolysis performance	72:103	Multifactorial effects of gluconic acid pretreatment of waste straws on enzymatic hydrolysis performance.
34954358	7	6	theme	GA	1186:1187	arg1	pretreatment					1189:1200	GA pretreatment	1186:1200	GA pretreatment of these waste straws	1186:1222	Hemicellulose removal was logically ascribed to be the trigger for cellulose saccharification efficiency during GA pretreatment of these waste straws.
34954358	1	7	theme	hydrolysis	266:275	arg1	effect					236:241	effect	236:241	effect of cellulose enzymatic hydrolysis	236:275	The chemical compositions of lignin, hemicellulose and cellulose are so far unascertained to various lignocellulose in respect to effect of cellulose enzymatic hydrolysis.
34954358	5	8	theme	residual	741:748	arg1	fraction					760:767	the residual cellulose fraction	737:767	the residual cellulose fraction	737:767	Next, for the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws, some mathematical correlations have been investigated between enzyme accessibility, hemicellulose removal rate, and cellulose crystallinity index.
34954358	6	9	theme	linear	947:952	arg1	models					968:973	Both linear and nonlinear models	942:973	Both linear and nonlinear models	942:973	Both linear and nonlinear models were compared using five-parameter logic curve, four-parameter logic curve, and Deming regression.
34954358	2	10	theme	gluconic	313:320	arg1	GA					328:329	GA	328:329	GA	328:329	The novel and environment-friendly gluconic acid (GA) pretreatment technology showed impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws.
34954358	2	10	theme	gluconic	313:320	arg1	acid					322:325	gluconic acid	313:325	The novel and environment-friendly gluconic acid (GA) pretreatment technology	278:354	The novel and environment-friendly gluconic acid (GA) pretreatment technology showed impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws.
34954358	2	11	theme	acid	322:325	arg1	technology					345:354	The novel and environment-friendly gluconic acid (GA) pretreatment technology	278:354	The novel and environment-friendly gluconic acid (GA) pretreatment technology	278:354	The novel and environment-friendly gluconic acid (GA) pretreatment technology showed impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws.
34954358	6	12	theme	four-parameter	1023:1036	arg1	curve					1044:1048	four-parameter logic curve	1023:1048	four-parameter logic curve	1023:1048	Both linear and nonlinear models were compared using five-parameter logic curve, four-parameter logic curve, and Deming regression.
34954358	5	13	theme	cellulose	750:758	arg1	fraction					760:767	the residual cellulose fraction	737:767	the residual cellulose fraction	737:767	Next, for the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws, some mathematical correlations have been investigated between enzyme accessibility, hemicellulose removal rate, and cellulose crystallinity index.
34954358	6	14	theme	logic	1038:1042	arg1	curve					1044:1048	four-parameter logic curve	1023:1048	four-parameter logic curve	1023:1048	Both linear and nonlinear models were compared using five-parameter logic curve, four-parameter logic curve, and Deming regression.
34954358	2	15	theme	environment-friendly	292:311	arg1	technology					345:354	The novel and environment-friendly gluconic acid (GA) pretreatment technology	278:354	The novel and environment-friendly gluconic acid (GA) pretreatment technology	278:354	The novel and environment-friendly gluconic acid (GA) pretreatment technology showed impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws.
34954358	3	16	theme	critical	496:503	arg1	issues					505:510	critical issues	496:510	critical issues	496:510	However, only few of the main reasons or critical issues pertaining to this reaction are known.
34954358	5	17	theme	fraction	760:767	arg1	hydrolysis					723:732	the enzymatic hydrolysis	709:732	the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws	709:792	Next, for the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws, some mathematical correlations have been investigated between enzyme accessibility, hemicellulose removal rate, and cellulose crystallinity index.
34954358	3	18	theme	issues	505:510	arg1	few					469:471	few	469:471	few	469:471	However, only few of the main reasons or critical issues pertaining to this reaction are known.
34954358	7	19	theme	saccharification	1151:1166	arg1	efficiency					1168:1177	cellulose saccharification efficiency	1141:1177	cellulose saccharification efficiency	1141:1177	Hemicellulose removal was logically ascribed to be the trigger for cellulose saccharification efficiency during GA pretreatment of these waste straws.
34954358	3	20	theme	reasons	485:491	arg1	few					469:471	few	469:471	few	469:471	However, only few of the main reasons or critical issues pertaining to this reaction are known.
34954358	4	21	theme	different	677:685	arg1	conditions					687:696	different conditions	677:696	different conditions	677:696	Therefore, the novel GA pretreatment was carried out to remove hemicellulose from the three representative waste straws under different conditions.
34954358	5	22	from	hydrolysis	723:732	arg1	straws					787:792	the pretreated straws	772:792	the pretreated straws	772:792	Next, for the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws, some mathematical correlations have been investigated between enzyme accessibility, hemicellulose removal rate, and cellulose crystallinity index.
34954358	7	23	theme	straws	1217:1222	arg1	pretreatment					1189:1200	GA pretreatment	1186:1200	GA pretreatment of these waste straws	1186:1222	Hemicellulose removal was logically ascribed to be the trigger for cellulose saccharification efficiency during GA pretreatment of these waste straws.
34954358	4	24	theme	representative	643:656	arg1	straws					664:669	the three representative waste straws	633:669	the three representative waste straws	633:669	Therefore, the novel GA pretreatment was carried out to remove hemicellulose from the three representative waste straws under different conditions.
34954358	2	25	theme	novel	282:286	arg1	technology					345:354	The novel and environment-friendly gluconic acid (GA) pretreatment technology	278:354	The novel and environment-friendly gluconic acid (GA) pretreatment technology	278:354	The novel and environment-friendly gluconic acid (GA) pretreatment technology showed impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws.
34954358	2	26	theme	cellulose	413:421	arg1	hydrolysis					399:408	the enzymatic hydrolysis	385:408	the enzymatic hydrolysis of cellulose in various agricultural straws	385:452	The novel and environment-friendly gluconic acid (GA) pretreatment technology showed impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws.
34954358	6	27	theme	logic	1010:1014	arg1	curve					1016:1020	five-parameter logic curve	995:1020	five-parameter logic curve	995:1020	Both linear and nonlinear models were compared using five-parameter logic curve, four-parameter logic curve, and Deming regression.
34954358	2	28	from	results	374:380	arg1	hydrolysis					399:408	the enzymatic hydrolysis	385:408	the enzymatic hydrolysis of cellulose in various agricultural straws	385:452	The novel and environment-friendly gluconic acid (GA) pretreatment technology showed impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws.
34954358	0	29	theme	Multifactorial	0:13	arg1	effects					15:21	Multifactorial effects	0:21	Multifactorial effects of gluconic acid pretreatment of waste straws on enzymatic hydrolysis performance.	0:104	Multifactorial effects of gluconic acid pretreatment of waste straws on enzymatic hydrolysis performance.
34954358	4	30	theme	novel	566:570	arg1	pretreatment					575:586	the novel GA pretreatment	562:586	the novel GA pretreatment	562:586	Therefore, the novel GA pretreatment was carried out to remove hemicellulose from the three representative waste straws under different conditions.
34954358	7	31	theme	cellulose	1141:1149	arg1	efficiency					1168:1177	cellulose saccharification efficiency	1141:1177	cellulose saccharification efficiency	1141:1177	Hemicellulose removal was logically ascribed to be the trigger for cellulose saccharification efficiency during GA pretreatment of these waste straws.
34954358	5	32	theme	cellulose	911:919	arg1	index					935:939	cellulose crystallinity index	911:939	cellulose crystallinity index	911:939	Next, for the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws, some mathematical correlations have been investigated between enzyme accessibility, hemicellulose removal rate, and cellulose crystallinity index.
34954358	0	33	theme	gluconic	26:33	arg1	pretreatment					40:51	gluconic acid pretreatment	26:51	gluconic acid pretreatment of waste straws	26:67	Multifactorial effects of gluconic acid pretreatment of waste straws on enzymatic hydrolysis performance.
34954358	5	34	theme	enzymatic	713:721	arg1	hydrolysis					723:732	the enzymatic hydrolysis	709:732	the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws	709:792	Next, for the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws, some mathematical correlations have been investigated between enzyme accessibility, hemicellulose removal rate, and cellulose crystallinity index.
34954358	1	35	theme	various	199:205	arg1	lignocellulose					207:220	various lignocellulose	199:220	various lignocellulose	199:220	The chemical compositions of lignin, hemicellulose and cellulose are so far unascertained to various lignocellulose in respect to effect of cellulose enzymatic hydrolysis.
34954358	5	36	theme	enzyme	857:862	arg1	accessibility					864:876	enzyme accessibility	857:876	enzyme accessibility	857:876	Next, for the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws, some mathematical correlations have been investigated between enzyme accessibility, hemicellulose removal rate, and cellulose crystallinity index.
34954358	1	37	theme	chemical	110:117	arg1	compositions					119:130	The chemical compositions	106:130	The chemical compositions of lignin, hemicellulose and cellulose	106:169	The chemical compositions of lignin, hemicellulose and cellulose are so far unascertained to various lignocellulose in respect to effect of cellulose enzymatic hydrolysis.
34954358	1	38	theme	hemicellulose	143:155	arg1	compositions					119:130	The chemical compositions	106:130	The chemical compositions of lignin, hemicellulose and cellulose	106:169	The chemical compositions of lignin, hemicellulose and cellulose are so far unascertained to various lignocellulose in respect to effect of cellulose enzymatic hydrolysis.
34954358	0	39	theme	pretreatment	40:51	arg1	effects					15:21	Multifactorial effects	0:21	Multifactorial effects of gluconic acid pretreatment of waste straws on enzymatic hydrolysis performance.	0:104	Multifactorial effects of gluconic acid pretreatment of waste straws on enzymatic hydrolysis performance.
34954358	4	40	theme	GA	572:573	arg1	pretreatment					575:586	the novel GA pretreatment	562:586	the novel GA pretreatment	562:586	Therefore, the novel GA pretreatment was carried out to remove hemicellulose from the three representative waste straws under different conditions.
34954358	5	41	theme	hemicellulose	879:891	arg1	rate					901:904	hemicellulose removal rate	879:904	hemicellulose removal rate	879:904	Next, for the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws, some mathematical correlations have been investigated between enzyme accessibility, hemicellulose removal rate, and cellulose crystallinity index.
34954358	2	42	theme	agricultural	434:445	arg1	straws					447:452	various agricultural straws	426:452	various agricultural straws	426:452	The novel and environment-friendly gluconic acid (GA) pretreatment technology showed impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws.
34954358	0	43	theme	acid	35:38	arg1	pretreatment					40:51	gluconic acid pretreatment	26:51	gluconic acid pretreatment of waste straws	26:67	Multifactorial effects of gluconic acid pretreatment of waste straws on enzymatic hydrolysis performance.
34954358	6	44	theme	five-parameter	995:1008	arg1	curve					1016:1020	five-parameter logic curve	995:1020	five-parameter logic curve	995:1020	Both linear and nonlinear models were compared using five-parameter logic curve, four-parameter logic curve, and Deming regression.
34954358	5	45	theme	mathematical	800:811	arg1	correlations					813:824	some mathematical correlations	795:824	some mathematical correlations	795:824	Next, for the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws, some mathematical correlations have been investigated between enzyme accessibility, hemicellulose removal rate, and cellulose crystallinity index.
34954358	6	46	theme	Deming	1055:1060	arg1	regression					1062:1071	Deming regression	1055:1071	Deming regression	1055:1071	Both linear and nonlinear models were compared using five-parameter logic curve, four-parameter logic curve, and Deming regression.
34954358	5	47	theme	removal	893:899	arg1	rate					901:904	hemicellulose removal rate	879:904	hemicellulose removal rate	879:904	Next, for the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws, some mathematical correlations have been investigated between enzyme accessibility, hemicellulose removal rate, and cellulose crystallinity index.
34954358	2	48	theme	various	426:432	arg1	straws					447:452	various agricultural straws	426:452	various agricultural straws	426:452	The novel and environment-friendly gluconic acid (GA) pretreatment technology showed impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws.
34954358	0	49	theme	waste	56:60	arg1	straws					62:67	waste straws	56:67	waste straws	56:67	Multifactorial effects of gluconic acid pretreatment of waste straws on enzymatic hydrolysis performance.
34954358	5	50	theme	crystallinity	921:933	arg1	index					935:939	cellulose crystallinity index	911:939	cellulose crystallinity index	911:939	Next, for the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws, some mathematical correlations have been investigated between enzyme accessibility, hemicellulose removal rate, and cellulose crystallinity index.
34954358	5	51	theme	pretreated	776:785	arg1	straws					787:792	the pretreated straws	772:792	the pretreated straws	772:792	Next, for the enzymatic hydrolysis of the residual cellulose fraction in the pretreated straws, some mathematical correlations have been investigated between enzyme accessibility, hemicellulose removal rate, and cellulose crystallinity index.
34954358	2	52	from	hydrolysis	399:408	arg1	straws					447:452	various agricultural straws	426:452	various agricultural straws	426:452	The novel and environment-friendly gluconic acid (GA) pretreatment technology showed impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws.
34954358	2	53	theme	impressive	363:372	arg1	results					374:380	impressive results	363:380	impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws	363:452	The novel and environment-friendly gluconic acid (GA) pretreatment technology showed impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws.
34954358	7	54	theme	waste	1211:1215	arg1	straws					1217:1222	these waste straws	1205:1222	these waste straws	1205:1222	Hemicellulose removal was logically ascribed to be the trigger for cellulose saccharification efficiency during GA pretreatment of these waste straws.
34954358	1	55	theme	lignin	135:140	arg1	compositions					119:130	The chemical compositions	106:130	The chemical compositions of lignin, hemicellulose and cellulose	106:169	The chemical compositions of lignin, hemicellulose and cellulose are so far unascertained to various lignocellulose in respect to effect of cellulose enzymatic hydrolysis.
34954358	7	56	theme	Hemicellulose	1074:1086	arg1	removal					1088:1094	Hemicellulose removal	1074:1094	Hemicellulose removal	1074:1094	Hemicellulose removal was logically ascribed to be the trigger for cellulose saccharification efficiency during GA pretreatment of these waste straws.
34954358	7	56	theme	Hemicellulose	1074:1086	arg1	trigger					1129:1135	the trigger	1125:1135	the trigger for cellulose saccharification efficiency	1125:1177	Hemicellulose removal was logically ascribed to be the trigger for cellulose saccharification efficiency during GA pretreatment of these waste straws.
34954358	2	57	theme	pretreatment	332:343	arg1	technology					345:354	The novel and environment-friendly gluconic acid (GA) pretreatment technology	278:354	The novel and environment-friendly gluconic acid (GA) pretreatment technology	278:354	The novel and environment-friendly gluconic acid (GA) pretreatment technology showed impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws.
34954358	4	58	theme	waste	658:662	arg1	straws					664:669	the three representative waste straws	633:669	the three representative waste straws	633:669	Therefore, the novel GA pretreatment was carried out to remove hemicellulose from the three representative waste straws under different conditions.
34954358	3	59	theme	main	480:483	arg1	reasons					485:491	main reasons	480:491	main reasons	480:491	However, only few of the main reasons or critical issues pertaining to this reaction are known.
34954358	2	60	theme	enzymatic	389:397	arg1	hydrolysis					399:408	the enzymatic hydrolysis	385:408	the enzymatic hydrolysis of cellulose in various agricultural straws	385:452	The novel and environment-friendly gluconic acid (GA) pretreatment technology showed impressive results on the enzymatic hydrolysis of cellulose in various agricultural straws.
34954358	0	61	theme	straws	62:67	arg1	pretreatment					40:51	gluconic acid pretreatment	26:51	gluconic acid pretreatment of waste straws	26:67	Multifactorial effects of gluconic acid pretreatment of waste straws on enzymatic hydrolysis performance.
34954358	3	62	dep	reasons	485:491	arg1	the					476:478	the	476:478	the	476:478	However, only few of the main reasons or critical issues pertaining to this reaction are known.
34954358	1	63	theme	cellulose	246:254	arg1	hydrolysis					266:275	cellulose enzymatic hydrolysis	246:275	cellulose enzymatic hydrolysis	246:275	The chemical compositions of lignin, hemicellulose and cellulose are so far unascertained to various lignocellulose in respect to effect of cellulose enzymatic hydrolysis.
33255932	4	0	theme	structure	695:703	arg1	investigation					674:686	The investigation	670:686	The investigation of the structure of the lipid A from cold-adapted bacteria	670:745	The investigation of the structure of the lipid A from cold-adapted bacteria is, therefore, crucial to understand the mechanisms underlying the cold adaptation phenomenon.
33255932	4	0	theme	structure	695:703	arg1	crucial					762:768	crucial	762:768	crucial	762:768	The investigation of the structure of the lipid A from cold-adapted bacteria is, therefore, crucial to understand the mechanisms underlying the cold adaptation phenomenon.
33255932	7	1	theme	immune	1320:1325	arg1	response					1327:1334	innate immune response	1313:1334	innate immune response	1313:1334	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	6	2	theme	lipid	996:1000	arg1	structures					1004:1013	All the lipid A structures	988:1013	All the lipid A structures	988:1013	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	5	3	theme	heterogenous	900:911	arg1	A					919:919	the highly heterogenous lipid A	889:919	the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica	889:985	Here we describe the structural elucidation of the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica.
33255932	6	4	theme	compositional	1079:1091	arg1	analysis					1093:1100	the compositional analysis	1075:1100	the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation	1075:1242	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	5	theme	of	1183:1184	arg1	spectrometry					1204:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry	1124:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS)	1124:1220	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	5	theme	of	1183:1184	arg1	MS					1218:1219	MS	1218:1219	MS	1218:1219	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	6	theme	laser	1142:1146	arg1	spectrometry					1204:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry	1124:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS)	1124:1220	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	6	theme	laser	1142:1146	arg1	MS					1218:1219	MS	1218:1219	MS	1218:1219	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	7	from	investigation	1230:1242	arg1	information					1107:1117	information	1107:1117	information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation	1107:1242	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	0	8	theme	Antarctic	82:90	arg1	Environments					92:103	Antarctic Environments	82:103	Antarctic Environments	82:103	The Structure of the Lipid A of Gram-Negative Cold-Adapted Bacteria Isolated from Antarctic Environments.
33255932	7	9	from	bacteria	1414:1421	arg1	characterization					1363:1378	the structural characterization	1348:1378	the structural characterization of lipid A from such extremophile bacteria	1348:1421	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	7	9	from	bacteria	1414:1421	arg1	A					1389:1389	lipid A	1383:1389	lipid A from such extremophile bacteria	1383:1421	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	3	10	theme	several	534:540	arg1	modifications					553:565	several structural modifications	534:565	several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching	534:667	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	2	11	theme	main	294:297	arg1	component					299:307	the main component	290:307	the main component of their outer membrane	290:331	Unusual chemical modifications of the lipopolysaccharide (LPS) and the main component of their outer membrane are among the tricks adopted to allow the maintenance of an optimum membrane fluidity even at particularly low temperatures.
33255932	4	12	theme	lipid	712:716	arg1	A					718:718	the lipid A	708:718	the lipid A from cold-adapted bacteria	708:745	The investigation of the structure of the lipid A from cold-adapted bacteria is, therefore, crucial to understand the mechanisms underlying the cold adaptation phenomenon.
33255932	3	13	from	increase	641:648	arg1	branching					659:667	their branching	653:667	their branching	653:667	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	3	13	from	increase	641:648	arg1	length					630:635	their length	624:635	their length	624:635	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	3	14	theme	glycolipid	482:491	arg1	moiety					493:498	the LPS' glycolipid moiety	473:498	the LPS' glycolipid moiety	473:498	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	3	14	theme	glycolipid	482:491	arg1	A					511:511	the lipid A	501:511	the lipid A	501:511	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	4	15	theme	cold-adapted	725:736	arg1	bacteria					738:745	cold-adapted bacteria	725:745	cold-adapted bacteria	725:745	The investigation of the structure of the lipid A from cold-adapted bacteria is, therefore, crucial to understand the mechanisms underlying the cold adaptation phenomenon.
33255932	3	16	from	reduction	611:619	arg1	branching					659:667	their branching	653:667	their branching	653:667	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	3	16	from	reduction	611:619	arg1	length					630:635	their length	624:635	their length	624:635	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	2	17	theme	optimum	393:399	arg1	fluidity					410:417	an optimum membrane fluidity	390:417	an optimum membrane fluidity	390:417	Unusual chemical modifications of the lipopolysaccharide (LPS) and the main component of their outer membrane are among the tricks adopted to allow the maintenance of an optimum membrane fluidity even at particularly low temperatures.
33255932	7	18	from	elicitation	1298:1308	arg1	mammals					1339:1345	mammals	1339:1345	mammals	1339:1345	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	6	19	theme	MS2	1226:1228	arg1	investigation					1230:1242	MS2 investigation	1226:1242	MS2 investigation	1226:1242	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	20	theme	MALDI	1171:1175	arg1	spectrometry					1204:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry	1124:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS)	1124:1220	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	20	theme	MALDI	1171:1175	arg1	MS					1218:1219	MS	1218:1219	MS	1218:1219	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	7	21	theme	lipid	1383:1387	arg1	A					1389:1389	lipid A	1383:1389	lipid A from such extremophile bacteria	1383:1421	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	6	22	with	analysis	1093:1100	arg1	information					1107:1117	information	1107:1117	information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation	1107:1242	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	4	23	from	bacteria	738:745	arg1	structure					695:703	the structure	691:703	the structure of the lipid A from cold-adapted bacteria	691:745	The investigation of the structure of the lipid A from cold-adapted bacteria is, therefore, crucial to understand the mechanisms underlying the cold adaptation phenomenon.
33255932	4	23	from	bacteria	738:745	arg1	A					718:718	the lipid A	708:718	the lipid A from cold-adapted bacteria	708:745	The investigation of the structure of the lipid A from cold-adapted bacteria is, therefore, crucial to understand the mechanisms underlying the cold adaptation phenomenon.
33255932	2	24	theme	membrane	324:331	arg1	component					299:307	the main component	290:307	the main component of their outer membrane	290:331	Unusual chemical modifications of the lipopolysaccharide (LPS) and the main component of their outer membrane are among the tricks adopted to allow the maintenance of an optimum membrane fluidity even at particularly low temperatures.
33255932	2	24	theme	membrane	324:331	arg1	modifications					240:252	Unusual chemical modifications	223:252	Unusual chemical modifications of the lipopolysaccharide (LPS)	223:284	Unusual chemical modifications of the lipopolysaccharide (LPS) and the main component of their outer membrane are among the tricks adopted to allow the maintenance of an optimum membrane fluidity even at particularly low temperatures.
33255932	7	25	theme	great	1434:1438	arg1	interest					1440:1447	great interest	1434:1447	great interest	1434:1447	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	5	26	theme	structural	863:872	arg1	elucidation					874:884	the structural elucidation	859:884	the structural elucidation of the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica	859:985	Here we describe the structural elucidation of the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica.
33255932	7	27	theme	extremophile	1401:1412	arg1	bacteria					1414:1421	such extremophile bacteria	1396:1421	such extremophile bacteria	1396:1421	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	6	28	theme	matrix-assisted	1126:1140	arg1	spectrometry					1204:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry	1124:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS)	1124:1220	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	28	theme	matrix-assisted	1126:1140	arg1	MS					1218:1219	MS	1218:1219	MS	1218:1219	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	2	29	theme	outer	318:322	arg1	membrane					324:331	their outer membrane	312:331	their outer membrane	312:331	Unusual chemical modifications of the lipopolysaccharide (LPS) and the main component of their outer membrane are among the tricks adopted to allow the maintenance of an optimum membrane fluidity even at particularly low temperatures.
33255932	7	30	theme	structure-dependent	1278:1296	arg1	elicitation					1298:1308	a structure-dependent elicitation	1276:1308	a structure-dependent elicitation of innate immune response in mammals	1276:1345	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	2	31	theme	low	440:442	arg1	temperatures					444:455	particularly low temperatures	427:455	particularly low temperatures	427:455	Unusual chemical modifications of the lipopolysaccharide (LPS) and the main component of their outer membrane are among the tricks adopted to allow the maintenance of an optimum membrane fluidity even at particularly low temperatures.
33255932	7	32	theme	A	1389:1389	arg1	characterization					1363:1378	the structural characterization	1348:1378	the structural characterization of lipid A from such extremophile bacteria	1348:1421	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	4	33	theme	cold	814:817	arg1	phenomenon					830:839	the cold adaptation phenomenon	810:839	the cold adaptation phenomenon	810:839	The investigation of the structure of the lipid A from cold-adapted bacteria is, therefore, crucial to understand the mechanisms underlying the cold adaptation phenomenon.
33255932	3	34	theme	structural	542:551	arg1	modifications					553:565	several structural modifications	534:565	several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching	534:667	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	1	35	theme	cold	205:208	arg1	environment					210:220	an extremely cold environment	192:220	an extremely cold environment	192:220	Gram-negative Antarctic bacteria adopt survival strategies to live and proliferate in an extremely cold environment.
33255932	6	36	theme	ionization	1159:1168	arg1	spectrometry					1204:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry	1124:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS)	1124:1220	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	36	theme	ionization	1159:1168	arg1	MS					1218:1219	MS	1218:1219	MS	1218:1219	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	37	from	spectrometry	1204:1215	arg1	information					1107:1117	information	1107:1117	information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation	1107:1242	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	1	38	theme	Gram-negative	106:118	arg1	bacteria					130:137	Gram-negative Antarctic bacteria	106:137	Gram-negative Antarctic bacteria	106:137	Gram-negative Antarctic bacteria adopt survival strategies to live and proliferate in an extremely cold environment.
33255932	6	39	theme	merging	1039:1045	arg1	data					1047:1050	merging data	1039:1050	merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation	1039:1242	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	0	40	theme	A	27:27	arg1	Structure					4:12	The Structure	0:12	The Structure of the Lipid A of Gram-Negative Cold-Adapted Bacteria	0:66	The Structure of the Lipid A of Gram-Negative Cold-Adapted Bacteria Isolated from Antarctic Environments.
33255932	7	41	theme	natural	1516:1522	arg1	sources					1524:1530	natural sources	1516:1530	natural sources	1516:1530	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	3	42	theme	acyl	598:601	arg1	chains					603:608	the acyl chains	594:608	the acyl chains	594:608	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	2	43	theme	fluidity	410:417	arg1	maintenance					375:385	the maintenance	371:385	the maintenance of an optimum membrane fluidity	371:417	Unusual chemical modifications of the lipopolysaccharide (LPS) and the main component of their outer membrane are among the tricks adopted to allow the maintenance of an optimum membrane fluidity even at particularly low temperatures.
33255932	0	44	theme	Lipid	21:25	arg1	A					27:27	the Lipid A	17:27	the Lipid A of Gram-Negative Cold-Adapted Bacteria	17:66	The Structure of the Lipid A of Gram-Negative Cold-Adapted Bacteria Isolated from Antarctic Environments.
33255932	5	45	attach	isolated	946:953	arg2	psychrophiles					932:944	three psychrophiles	926:944	three psychrophiles isolated from Terra Nova Bay, Antarctica	926:985	Here we describe the structural elucidation of the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica.
33255932	5	45	attach	isolated	946:953	arg1	Antarctica					976:985	Antarctica	976:985	Antarctica	976:985	Here we describe the structural elucidation of the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica.
33255932	7	46	theme	development	1492:1502	arg1	perspective					1458:1468	the perspective	1454:1468	the perspective of drug synthesis and development inspired by natural sources	1454:1530	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	3	47	theme	chains	603:608	arg1	increase					641:648	increase	641:648	increase in their branching	641:667	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	3	47	theme	chains	603:608	arg1	reduction					611:619	reduction	611:619	reduction in their length	611:635	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	3	47	theme	chains	603:608	arg1	desaturation					578:589	desaturation	578:589	desaturation of the acyl chains	578:608	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	2	48	theme	membrane	401:408	arg1	fluidity					410:417	an optimum membrane fluidity	390:417	an optimum membrane fluidity	390:417	Unusual chemical modifications of the lipopolysaccharide (LPS) and the main component of their outer membrane are among the tricks adopted to allow the maintenance of an optimum membrane fluidity even at particularly low temperatures.
33255932	0	49	theme	Gram-Negative	32:44	arg1	Bacteria					59:66	Gram-Negative Cold-Adapted Bacteria	32:66	Gram-Negative Cold-Adapted Bacteria	32:66	The Structure of the Lipid A of Gram-Negative Cold-Adapted Bacteria Isolated from Antarctic Environments.
33255932	4	50	theme	adaptation	819:828	arg1	phenomenon					830:839	the cold adaptation phenomenon	810:839	the cold adaptation phenomenon	810:839	The investigation of the structure of the lipid A from cold-adapted bacteria is, therefore, crucial to understand the mechanisms underlying the cold adaptation phenomenon.
33255932	1	51	theme	Antarctic	120:128	arg1	bacteria					130:137	Gram-negative Antarctic bacteria	106:137	Gram-negative Antarctic bacteria	106:137	Gram-negative Antarctic bacteria adopt survival strategies to live and proliferate in an extremely cold environment.
33255932	7	52	from	perspective	1458:1468	arg1	interest					1440:1447	great interest	1434:1447	great interest	1434:1447	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	6	53	theme	time	1178:1181	arg1	spectrometry					1204:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry	1124:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS)	1124:1220	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	53	theme	time	1178:1181	arg1	MS					1218:1219	MS	1218:1219	MS	1218:1219	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	2	54	theme	Unusual	223:229	arg1	modifications					240:252	Unusual chemical modifications	223:252	Unusual chemical modifications of the lipopolysaccharide (LPS)	223:284	Unusual chemical modifications of the lipopolysaccharide (LPS) and the main component of their outer membrane are among the tricks adopted to allow the maintenance of an optimum membrane fluidity even at particularly low temperatures.
33255932	2	55	theme	chemical	231:238	arg1	modifications					240:252	Unusual chemical modifications	223:252	Unusual chemical modifications of the lipopolysaccharide (LPS)	223:284	Unusual chemical modifications of the lipopolysaccharide (LPS) and the main component of their outer membrane are among the tricks adopted to allow the maintenance of an optimum membrane fluidity even at particularly low temperatures.
33255932	7	56	theme	lipid	1248:1252	arg1	A					1254:1254	lipid A	1248:1254	lipid A	1248:1254	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	5	57	theme	A	919:919	arg1	elucidation					874:884	the structural elucidation	859:884	the structural elucidation of the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica	859:985	Here we describe the structural elucidation of the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica.
33255932	6	58	theme	mass	1199:1202	arg1	spectrometry					1204:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry	1124:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS)	1124:1220	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	58	theme	mass	1199:1202	arg1	MS					1218:1219	MS	1218:1219	MS	1218:1219	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	59	theme	flight	1186:1191	arg1	spectrometry					1204:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry	1124:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS)	1124:1220	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	59	theme	flight	1186:1191	arg1	MS					1218:1219	MS	1218:1219	MS	1218:1219	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	7	60	theme	response	1327:1334	arg1	elicitation					1298:1308	a structure-dependent elicitation	1276:1308	a structure-dependent elicitation of innate immune response in mammals	1276:1345	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	7	61	theme	synthesis	1478:1486	arg1	perspective					1458:1468	the perspective	1454:1468	the perspective of drug synthesis and development inspired by natural sources	1454:1530	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	7	62	theme	structural	1352:1361	arg1	characterization					1363:1378	the structural characterization	1348:1378	the structural characterization of lipid A from such extremophile bacteria	1348:1421	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	3	63	theme	LPS	477:479	arg1	moiety					493:498	the LPS' glycolipid moiety	473:498	the LPS' glycolipid moiety	473:498	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	3	63	theme	LPS	477:479	arg1	A					511:511	the lipid A	501:511	the lipid A	501:511	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	6	64	theme	desorption	1148:1157	arg1	spectrometry					1204:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry	1124:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS)	1124:1220	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	64	theme	desorption	1148:1157	arg1	MS					1218:1219	MS	1218:1219	MS	1218:1219	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	7	65	theme	such	1396:1399	arg1	bacteria					1414:1421	such extremophile bacteria	1396:1421	such extremophile bacteria	1396:1421	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	5	66	theme	lipid	913:917	arg1	A					919:919	the highly heterogenous lipid A	889:919	the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica	889:985	Here we describe the structural elucidation of the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica.
33255932	6	67	theme	TOF	1194:1196	arg1	spectrometry					1204:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry	1124:1215	a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS)	1124:1220	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	6	67	theme	TOF	1194:1196	arg1	MS					1218:1219	MS	1218:1219	MS	1218:1219	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
33255932	1	68	theme	survival	145:152	arg1	strategies					154:163	survival strategies	145:163	survival strategies	145:163	Gram-negative Antarctic bacteria adopt survival strategies to live and proliferate in an extremely cold environment.
33255932	5	69	from	psychrophiles	932:944	arg1	A					919:919	the highly heterogenous lipid A	889:919	the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica	889:985	Here we describe the structural elucidation of the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica.
33255932	5	69	from	psychrophiles	932:944	arg1	elucidation					874:884	the structural elucidation	859:884	the structural elucidation of the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica	859:985	Here we describe the structural elucidation of the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica.
33255932	4	70	theme	A	718:718	arg1	structure					695:703	the structure	691:703	the structure of the lipid A from cold-adapted bacteria	691:745	The investigation of the structure of the lipid A from cold-adapted bacteria is, therefore, crucial to understand the mechanisms underlying the cold adaptation phenomenon.
33255932	0	71	theme	Bacteria	59:66	arg1	A					27:27	the Lipid A	17:27	the Lipid A of Gram-Negative Cold-Adapted Bacteria	17:66	The Structure of the Lipid A of Gram-Negative Cold-Adapted Bacteria Isolated from Antarctic Environments.
33255932	7	72	theme	drug	1473:1476	arg1	synthesis					1478:1486	drug synthesis	1473:1486	drug synthesis	1473:1486	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	7	73	theme	innate	1313:1318	arg1	response					1327:1334	innate immune response	1313:1334	innate immune response	1313:1334	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	5	74	from	elucidation	874:884	arg1	psychrophiles					932:944	three psychrophiles	926:944	three psychrophiles isolated from Terra Nova Bay, Antarctica	926:985	Here we describe the structural elucidation of the highly heterogenous lipid A from three psychrophiles isolated from Terra Nova Bay, Antarctica.
33255932	3	75	theme	lipid	505:509	arg1	moiety					493:498	the LPS' glycolipid moiety	473:498	the LPS' glycolipid moiety	473:498	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	3	75	theme	lipid	505:509	arg1	A					511:511	the lipid A	501:511	the lipid A	501:511	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	3	76	from	desaturation	578:589	arg1	branching					659:667	their branching	653:667	their branching	653:667	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	3	76	from	desaturation	578:589	arg1	length					630:635	their length	624:635	their length	624:635	In particular, the LPS' glycolipid moiety, the lipid A, typically undergoes several structural modifications comprising desaturation of the acyl chains, reduction in their length and increase in their branching.
33255932	0	77	theme	Cold-Adapted	46:57	arg1	Bacteria					59:66	Gram-Negative Cold-Adapted Bacteria	32:66	Gram-Negative Cold-Adapted Bacteria	32:66	The Structure of the Lipid A of Gram-Negative Cold-Adapted Bacteria Isolated from Antarctic Environments.
33255932	2	78	theme	lipopolysaccharide	261:278	arg1	component					299:307	the main component	290:307	the main component of their outer membrane	290:331	Unusual chemical modifications of the lipopolysaccharide (LPS) and the main component of their outer membrane are among the tricks adopted to allow the maintenance of an optimum membrane fluidity even at particularly low temperatures.
33255932	2	78	theme	lipopolysaccharide	261:278	arg1	modifications					240:252	Unusual chemical modifications	223:252	Unusual chemical modifications of the lipopolysaccharide (LPS)	223:284	Unusual chemical modifications of the lipopolysaccharide (LPS) and the main component of their outer membrane are among the tricks adopted to allow the maintenance of an optimum membrane fluidity even at particularly low temperatures.
33255932	7	79	from	characterization	1363:1378	arg1	bacteria					1414:1421	such extremophile bacteria	1396:1421	such extremophile bacteria	1396:1421	As lipid A is also involved in a structure-dependent elicitation of innate immune response in mammals, the structural characterization of lipid A from such extremophile bacteria is also of great interest from the perspective of drug synthesis and development inspired by natural sources.
33255932	4	80	from	structure	695:703	arg1	bacteria					738:745	cold-adapted bacteria	725:745	cold-adapted bacteria	725:745	The investigation of the structure of the lipid A from cold-adapted bacteria is, therefore, crucial to understand the mechanisms underlying the cold adaptation phenomenon.
33255932	6	81	theme	A	1002:1002	arg1	structures					1004:1013	All the lipid A structures	988:1013	All the lipid A structures	988:1013	All the lipid A structures have been determined by merging data that was attained from the compositional analysis with information from a matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectrometry (MS) and MS2 investigation.
32767164	5	0	dep	nm	970:971	arg1	750					966:968	750	966:968	750	966:968	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	3	1	theme	PS-embedded	525:535	arg1	films					558:562	PS-embedded composite biopolymer films	525:562	PS-embedded composite biopolymer films	525:562	Here, we report preparation of PS-embedded composite biopolymer films and their photobactericidal properties against methicillin-resistant Staphylococcus aureus (MRSA) and biocompatibility.
32767164	5	2	theme	films	1106:1110	arg1	studies					1083:1089	Absorption spectroscopic studies	1058:1089	Absorption spectroscopic studies of PS-embedded films	1058:1110	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	3	3	theme	photobactericidal	574:590	arg1	properties					592:601	their photobactericidal properties	568:601	their photobactericidal properties against methicillin-resistant Staphylococcus aureus (MRSA) and biocompatibility	568:681	Here, we report preparation of PS-embedded composite biopolymer films and their photobactericidal properties against methicillin-resistant Staphylococcus aureus (MRSA) and biocompatibility.
32767164	2	4	from	step	382:385	arg1	approach					275:282	this approach	270:282	this approach	270:282	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	1	5	theme	antibiotic-resistant	236:255	arg1	bacteria					257:264	antibiotic-resistant bacteria	236:264	antibiotic-resistant bacteria	236:264	Antimicrobial photodynamic therapy (APDT) is a promising approach for treatment of wounds infected with antibiotic-resistant bacteria.
32767164	8	6	with	treatment	1845:1853	arg1	films					1874:1878	PS-containing films	1860:1878	PS-containing films	1860:1878	Studies on human keratinocyte (HaCaT) cells showed that there was no significant change in the viability of cells when they were incubated with solubilized films (plain) for 24 h or subjected to treatment with PS-containing films followed by PDT.
32767164	8	7	theme	keratinocyte	1667:1678	arg1	cells					1688:1692	human keratinocyte (HaCaT) cells	1661:1692	human keratinocyte (HaCaT) cells	1661:1692	Studies on human keratinocyte (HaCaT) cells showed that there was no significant change in the viability of cells when they were incubated with solubilized films (plain) for 24 h or subjected to treatment with PS-containing films followed by PDT.
32767164	5	8	theme	swelling	989:996	arg1	rate					998:1001	high swelling rate	984:1001	high swelling rate	984:1001	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	7	9	with	treatment	1421:1429	arg1	Cp6					1463:1465	Cp6	1463:1465	Cp6 embedded in film or free Cp6	1463:1494	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	8	10	theme	HaCaT	1681:1685	arg1	cells					1688:1692	human keratinocyte (HaCaT) cells	1661:1692	human keratinocyte (HaCaT) cells	1661:1692	Studies on human keratinocyte (HaCaT) cells showed that there was no significant change in the viability of cells when they were incubated with solubilized films (plain) for 24 h or subjected to treatment with PS-containing films followed by PDT.
32767164	7	11	dep	treatment	1421:1429	arg1	nm					1436:1437	660 nm	1432:1437	660 nm	1432:1437	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	7	11	dep	treatment	1421:1429	arg1	J/cm2					1443:1447	10 J/cm2	1440:1447	10 J/cm2	1440:1447	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	7	12	theme	MRSA	1453:1456	arg1	treatment					1421:1429	photodynamic treatment	1408:1429	photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6	1408:1494	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	5	13	theme	mm	888:889	arg1	diameter					891:898	15 mm diameter	885:898	15 mm diameter; 110 ± 09 μm thickness	885:921	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	5	14	theme	15	885:886	arg1	mm					888:889	mm	888:889	mm	888:889	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	6	15	theme	substantial	1266:1276	arg1	uptake					1278:1283	substantial uptake	1266:1283	substantial uptake of Cp6 and MB	1266:1297	MRSA incubated with the film for 1 h displayed substantial uptake of Cp6 and MB as indicated by the presence of Cp6 fluorescence and MB staining in cells under the microscope.
32767164	5	16	theme	38	1021:1022	arg1	%					1023:1023	%	1023:1023	%	1023:1023	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	2	17	theme	appropriate	297:307	arg1	concentration					309:321	appropriate concentration	297:321	appropriate concentration of photosensitizer (PS)	297:345	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	2	17	theme	appropriate	297:307	arg1	PS					343:344	PS	343:344	PS	343:344	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	4	18	theme	carboxymethyl	723:735	arg1	CMC					748:750	CMC	748:750	CMC	748:750	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	4	18	theme	carboxymethyl	723:735	arg1	cellulose					737:745	carboxymethyl cellulose	723:745	carboxymethyl cellulose (CMC)	723:751	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	5	19	theme	monomeric	1154:1162	arg1	state					1164:1168	monomeric state	1154:1168	monomeric state	1154:1168	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	9	20	theme	potential	1957:1965	arg1	application					1967:1977	potential application	1957:1977	potential application	1957:1977	These results suggest that films are biocompatible and have potential application in photodynamic treatment of MRSA-infected wounds.
32767164	5	21	theme	%	878:878	arg1	CMC					880:882	1% CMC	877:882	1% CMC (15 mm diameter; 110 ± 09 μm thickness)	877:922	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	5	22	from	rate	998:1001	arg1	region					973:978	500 to 750 nm region	959:978	500 to 750 nm region	959:978	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	5	23	theme	μm	910:911	arg1	thickness					913:921	110 ± 09 μm thickness	901:921	15 mm diameter; 110 ± 09 μm thickness	885:921	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	7	24	theme	log	1512:1514	arg1	reduction					1516:1524	~ 3 log reduction	1508:1524	~ 3 log reduction in colony-forming units (cfu)	1508:1554	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	1	25	theme	promising	179:187	arg1	therapy					159:165	Antimicrobial photodynamic therapy	132:165	Antimicrobial photodynamic therapy (APDT)	132:172	Antimicrobial photodynamic therapy (APDT) is a promising approach for treatment of wounds infected with antibiotic-resistant bacteria.
32767164	1	25	theme	promising	179:187	arg1	approach					189:196	a promising approach	177:196	a promising approach for treatment of wounds infected with antibiotic-resistant bacteria	177:264	Antimicrobial photodynamic therapy (APDT) is a promising approach for treatment of wounds infected with antibiotic-resistant bacteria.
32767164	5	26	dep	h.	1055:1056	arg1	revealed					1112:1119	revealed	1112:1119	revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms	1112:1216	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	5	27	dep	CMC	880:882	arg1	diameter					891:898	15 mm diameter	885:898	15 mm diameter; 110 ± 09 μm thickness	885:921	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	5	28	from	increase	1025:1032	arg1	diameter					1037:1044	diameter	1037:1044	diameter	1037:1044	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	1	29	theme	Antimicrobial	132:144	arg1	therapy					159:165	Antimicrobial photodynamic therapy	132:165	Antimicrobial photodynamic therapy (APDT)	132:172	Antimicrobial photodynamic therapy (APDT) is a promising approach for treatment of wounds infected with antibiotic-resistant bacteria.
32767164	1	29	theme	Antimicrobial	132:144	arg1	approach					189:196	a promising approach	177:196	a promising approach for treatment of wounds infected with antibiotic-resistant bacteria	177:264	Antimicrobial photodynamic therapy (APDT) is a promising approach for treatment of wounds infected with antibiotic-resistant bacteria.
32767164	1	29	theme	Antimicrobial	132:144	arg1	APDT					168:171	APDT	168:171	APDT	168:171	Antimicrobial photodynamic therapy (APDT) is a promising approach for treatment of wounds infected with antibiotic-resistant bacteria.
32767164	7	30	theme	~	1508:1508	arg1	reduction					1516:1524	~ 3 log reduction	1508:1524	~ 3 log reduction in colony-forming units (cfu)	1508:1554	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	8	31	theme	solubilized	1794:1804	arg1	plain					1813:1817	plain	1813:1817	plain	1813:1817	Studies on human keratinocyte (HaCaT) cells showed that there was no significant change in the viability of cells when they were incubated with solubilized films (plain) for 24 h or subjected to treatment with PS-containing films followed by PDT.
32767164	8	31	theme	solubilized	1794:1804	arg1	films					1806:1810	solubilized films	1794:1810	solubilized films (plain)	1794:1818	Studies on human keratinocyte (HaCaT) cells showed that there was no significant change in the viability of cells when they were incubated with solubilized films (plain) for 24 h or subjected to treatment with PS-containing films followed by PDT.
32767164	9	32	theme	MRSA-infected	2008:2020	arg1	wounds					2022:2027	MRSA-infected wounds	2008:2027	MRSA-infected wounds	2008:2027	These results suggest that films are biocompatible and have potential application in photodynamic treatment of MRSA-infected wounds.
32767164	0	33	theme	Antibacterial	0:12	arg1	activity					27:34	Antibacterial photodynamic activity	0:34	Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films.	0:130	Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films.
32767164	5	34	theme	Absorption	1058:1067	arg1	studies					1083:1089	Absorption spectroscopic studies	1058:1089	Absorption spectroscopic studies of PS-embedded films	1058:1110	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	6	35	from	cells	1367:1371	arg1	presence					1319:1326	the presence	1315:1326	the presence of Cp6 fluorescence and MB staining in cells under the microscope	1315:1392	MRSA incubated with the film for 1 h displayed substantial uptake of Cp6 and MB as indicated by the presence of Cp6 fluorescence and MB staining in cells under the microscope.
32767164	8	36	dep	subjected	1832:1840	arg1	followed					1880:1887	followed	1880:1887	followed by PDT	1880:1894	Studies on human keratinocyte (HaCaT) cells showed that there was no significant change in the viability of cells when they were incubated with solubilized films (plain) for 24 h or subjected to treatment with PS-containing films followed by PDT.
32767164	8	37	theme	cells	1758:1762	arg1	viability					1745:1753	the viability	1741:1753	the viability of cells	1741:1762	Studies on human keratinocyte (HaCaT) cells showed that there was no significant change in the viability of cells when they were incubated with solubilized films (plain) for 24 h or subjected to treatment with PS-containing films followed by PDT.
32767164	5	38	theme	±	905:905	arg1	thickness					913:921	110 ± 09 μm thickness	901:921	15 mm diameter; 110 ± 09 μm thickness	885:921	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	7	39	theme	free	1487:1490	arg1	Cp6					1492:1494	free Cp6	1487:1494	free Cp6	1487:1494	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	0	40	theme	photosensitizer-embedded	39:62	arg1	films					125:129	photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films	39:129	photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films	39:129	Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films.
32767164	0	41	theme	biopolymer	114:123	arg1	films					125:129	photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films	39:129	photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films	39:129	Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films.
32767164	0	42	theme	cellulose	94:102	arg1	films					125:129	photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films	39:129	photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films	39:129	Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films.
32767164	6	43	from	staining	1355:1362	arg1	cells					1367:1371	cells	1367:1371	cells under the microscope	1367:1392	MRSA incubated with the film for 1 h displayed substantial uptake of Cp6 and MB as indicated by the presence of Cp6 fluorescence and MB staining in cells under the microscope.
32767164	7	44	dep	less	1585:1588	arg1	log					1595:1597	~ 1 log	1591:1597	~ 1 log	1591:1597	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	2	45	theme	critical	373:380	arg1	step					382:385	a critical step	371:385	a critical step	371:385	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	2	45	theme	critical	373:380	arg1	delivery					285:292	delivery	285:292	delivery of appropriate concentration of photosensitizer (PS) at the infected site	285:366	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	6	46	theme	staining	1355:1362	arg1	presence					1319:1326	the presence	1315:1326	the presence of Cp6 fluorescence and MB staining in cells under the microscope	1315:1392	MRSA incubated with the film for 1 h displayed substantial uptake of Cp6 and MB as indicated by the presence of Cp6 fluorescence and MB staining in cells under the microscope.
32767164	6	47	from	presence	1319:1326	arg1	cells					1367:1371	cells	1367:1371	cells under the microscope	1367:1392	MRSA incubated with the film for 1 h displayed substantial uptake of Cp6 and MB as indicated by the presence of Cp6 fluorescence and MB staining in cells under the microscope.
32767164	4	48	theme	anionic	811:817	arg1	Cp6					806:808	Cp6	806:808	Cp6	806:808	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	4	48	theme	anionic	811:817	arg1	PS					819:820	anionic PS	811:820	anionic PS	811:820	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	3	49	theme	composite	537:545	arg1	films					558:562	PS-embedded composite biopolymer films	525:562	PS-embedded composite biopolymer films	525:562	Here, we report preparation of PS-embedded composite biopolymer films and their photobactericidal properties against methicillin-resistant Staphylococcus aureus (MRSA) and biocompatibility.
32767164	6	50	theme	Cp6	1288:1290	arg1	uptake					1278:1283	substantial uptake	1266:1283	substantial uptake of Cp6 and MB	1266:1297	MRSA incubated with the film for 1 h displayed substantial uptake of Cp6 and MB as indicated by the presence of Cp6 fluorescence and MB staining in cells under the microscope.
32767164	6	51	theme	Cp6	1331:1333	arg1	fluorescence					1335:1346	Cp6 fluorescence	1331:1346	Cp6 fluorescence	1331:1346	MRSA incubated with the film for 1 h displayed substantial uptake of Cp6 and MB as indicated by the presence of Cp6 fluorescence and MB staining in cells under the microscope.
32767164	5	52	theme	PS-embedded	1094:1104	arg1	films					1106:1110	PS-embedded films	1094:1110	PS-embedded films	1094:1110	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	4	53	theme	cationic	846:853	arg1	MB					842:843	MB	842:843	MB	842:843	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	4	53	theme	cationic	846:853	arg1	PS					855:856	cationic PS	846:856	cationic PS	846:856	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	7	54	theme	~	1591:1591	arg1	log					1595:1597	~ 1 log	1591:1597	~ 1 log	1591:1597	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	5	55	dep	region	973:978	arg1	nm					970:971	nm	970:971	nm	970:971	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	4	56	used	used	758:761	arg2	pectin					706:711	pectin	706:711	pectin (PC)	706:716	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	4	56	used	used	758:761	arg2	PC					714:715	PC	714:715	PC	714:715	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	4	56	used	used	758:761	arg2	cellulose					737:745	carboxymethyl cellulose	723:745	carboxymethyl cellulose (CMC)	723:751	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	4	56	used	used	758:761	arg2	CMC					748:750	CMC	748:750	CMC	748:750	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	4	56	used	used	758:761	arg2	alginate					691:698	Sodium alginate	684:698	Sodium alginate (SA)	684:703	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	4	56	used	used	758:761	arg2	SA					701:702	SA	701:702	SA	701:702	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	5	57	dep	diameter	891:898	arg1	thickness					913:921	110 ± 09 μm thickness	901:921	15 mm diameter; 110 ± 09 μm thickness	885:921	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	5	58	dep	750	966:968	arg1	to					963:964	to	963:964	to	963:964	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	3	59	theme	films	558:562	arg1	preparation					510:520	preparation	510:520	preparation of PS-embedded composite biopolymer films	510:562	Here, we report preparation of PS-embedded composite biopolymer films and their photobactericidal properties against methicillin-resistant Staphylococcus aureus (MRSA) and biocompatibility.
32767164	3	59	theme	films	558:562	arg1	properties					592:601	their photobactericidal properties	568:601	their photobactericidal properties against methicillin-resistant Staphylococcus aureus (MRSA) and biocompatibility	568:681	Here, we report preparation of PS-embedded composite biopolymer films and their photobactericidal properties against methicillin-resistant Staphylococcus aureus (MRSA) and biocompatibility.
32767164	1	60	theme	wounds	215:220	arg1	treatment					202:210	treatment	202:210	treatment of wounds infected with antibiotic-resistant bacteria	202:264	Antimicrobial photodynamic therapy (APDT) is a promising approach for treatment of wounds infected with antibiotic-resistant bacteria.
32767164	4	61	theme	blue	836:839	arg1	methylene					826:834	methylene blue	826:839	methylene blue (MB, cationic PS)	826:857	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	5	62	dep	transmission	943:954	arg1	%					935:935	%	935:935	%	935:935	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	8	63	theme	human	1661:1665	arg1	cells					1688:1692	human keratinocyte (HaCaT) cells	1661:1692	human keratinocyte (HaCaT) cells	1661:1692	Studies on human keratinocyte (HaCaT) cells showed that there was no significant change in the viability of cells when they were incubated with solubilized films (plain) for 24 h or subjected to treatment with PS-containing films followed by PDT.
32767164	2	64	theme	infected	354:361	arg1	site					363:366	the infected site	350:366	the infected site	350:366	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	4	65	dep	methylene	826:834	arg1	MB					842:843	MB	842:843	MB	842:843	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	4	65	dep	methylene	826:834	arg1	PS					855:856	cationic PS	846:856	cationic PS	846:856	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	7	66	theme	embedded	1467:1474	arg1	Cp6					1463:1465	Cp6	1463:1465	Cp6 embedded in film or free Cp6	1463:1494	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	5	67	dep	%	935:935	arg1	55					933:934	55	933:934	55	933:934	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	5	68	theme	high	984:987	arg1	rate					998:1001	high swelling rate	984:1001	high swelling rate	984:1001	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	5	69	from	transmission	943:954	arg1	region					973:978	500 to 750 nm region	959:978	500 to 750 nm region	959:978	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	7	70	from	Cp6	1492:1494	arg1	embedded					1467:1474	embedded	1467:1474	embedded	1467:1474	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	4	71	contain	containing	783:792	arg2	methylene					826:834	methylene blue	826:839	methylene blue (MB, cationic PS)	826:857	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	4	71	contain	containing	783:792	arg2	p6					802:803	chlorin p6	794:803	chlorin p6 (Cp6, anionic PS)	794:821	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	4	71	contain	containing	783:792	arg1	films					777:781	films	777:781	films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS)	777:857	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	2	72	theme	photosensitizer	326:340	arg1	concentration					309:321	appropriate concentration	297:321	appropriate concentration of photosensitizer (PS)	297:345	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	2	72	theme	photosensitizer	326:340	arg1	PS					343:344	PS	343:344	PS	343:344	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	0	73	theme	alginate-pectin-carboxymethyl	64:92	arg1	films					125:129	photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films	39:129	photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films	39:129	Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films.
32767164	0	74	theme	films	125:129	arg1	activity					27:34	Antibacterial photodynamic activity	0:34	Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films.	0:130	Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films.
32767164	7	75	theme	colony-forming	1529:1542	arg1	units					1544:1548	colony-forming units	1529:1548	colony-forming units (cfu)	1529:1554	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	7	75	theme	colony-forming	1529:1542	arg1	cfu					1551:1553	cfu	1551:1553	cfu	1551:1553	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	2	76	theme	concentration	309:321	arg1	delivery					285:292	delivery	285:292	delivery of appropriate concentration of photosensitizer (PS) at the infected site	285:366	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	2	76	theme	concentration	309:321	arg1	step					382:385	a critical step	371:385	a critical step	371:385	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	4	77	dep	p6	802:803	arg1	Cp6					806:808	Cp6	806:808	Cp6	806:808	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	4	77	dep	p6	802:803	arg1	PS					819:820	anionic PS	811:820	anionic PS	811:820	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	2	78	from	site	462:465	arg1	formulation					481:491	a suitable formulation	470:491	a suitable formulation	470:491	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	7	79	from	reduction	1516:1524	arg1	units					1544:1548	colony-forming units	1529:1548	colony-forming units (cfu)	1529:1554	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	7	79	from	reduction	1516:1524	arg1	cfu					1551:1553	cfu	1551:1553	cfu	1551:1553	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	5	80	contain	containing	866:875	arg1	Films					860:864	Films	860:864	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness)	860:922	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	5	80	contain	containing	866:875	arg2	CMC					880:882	1% CMC	877:882	1% CMC (15 mm diameter; 110 ± 09 μm thickness)	877:922	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	8	81	theme	significant	1719:1729	arg1	change					1731:1736	no significant change	1716:1736	no significant change	1716:1736	Studies on human keratinocyte (HaCaT) cells showed that there was no significant change in the viability of cells when they were incubated with solubilized films (plain) for 24 h or subjected to treatment with PS-containing films followed by PDT.
32767164	5	82	theme	%	1023:1023	arg1	increase					1025:1032	38% increase	1021:1032	38% increase in diameter	1021:1044	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	5	83	theme	1	877:877	arg1	%					878:878	%	878:878	%	878:878	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	9	84	contain	have	1952:1955	arg2	application					1967:1977	potential application	1957:1977	potential application	1957:1977	These results suggest that films are biocompatible and have potential application in photodynamic treatment of MRSA-infected wounds.
32767164	9	84	contain	have	1952:1955	arg1	films					1924:1928	films	1924:1928	films	1924:1928	These results suggest that films are biocompatible and have potential application in photodynamic treatment of MRSA-infected wounds.
32767164	5	85	theme	09	907:908	arg1	thickness					913:921	110 ± 09 μm thickness	901:921	15 mm diameter; 110 ± 09 μm thickness	885:921	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	2	86	from	site	363:366	arg1	delivery					285:292	delivery	285:292	delivery of appropriate concentration of photosensitizer (PS) at the infected site	285:366	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	2	86	from	site	363:366	arg1	step					382:385	a critical step	371:385	a critical step	371:385	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	9	87	theme	photodynamic	1982:1993	arg1	treatment					1995:2003	photodynamic treatment	1982:2003	photodynamic treatment of MRSA-infected wounds	1982:2027	These results suggest that films are biocompatible and have potential application in photodynamic treatment of MRSA-infected wounds.
32767164	7	88	from	embedded	1467:1474	arg1	film					1479:1482	film	1479:1482	film	1479:1482	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	7	88	from	embedded	1467:1474	arg1	Cp6					1492:1494	free Cp6	1487:1494	free Cp6	1487:1494	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	4	89	theme	chlorin	794:800	arg1	p6					802:803	chlorin p6	794:803	chlorin p6 (Cp6, anionic PS)	794:821	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	0	90	theme	photodynamic	14:25	arg1	activity					27:34	Antibacterial photodynamic activity	0:34	Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films.	0:130	Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films.
32767164	7	91	from	film	1479:1482	arg1	embedded					1467:1474	embedded	1467:1474	embedded	1467:1474	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	1	92	theme	photodynamic	146:157	arg1	therapy					159:165	Antimicrobial photodynamic therapy	132:165	Antimicrobial photodynamic therapy (APDT)	132:172	Antimicrobial photodynamic therapy (APDT) is a promising approach for treatment of wounds infected with antibiotic-resistant bacteria.
32767164	1	92	theme	photodynamic	146:157	arg1	approach					189:196	a promising approach	177:196	a promising approach for treatment of wounds infected with antibiotic-resistant bacteria	177:264	Antimicrobial photodynamic therapy (APDT) is a promising approach for treatment of wounds infected with antibiotic-resistant bacteria.
32767164	1	92	theme	photodynamic	146:157	arg1	APDT					168:171	APDT	168:171	APDT	168:171	Antimicrobial photodynamic therapy (APDT) is a promising approach for treatment of wounds infected with antibiotic-resistant bacteria.
32767164	5	93	theme	dimeric	1190:1196	arg1	forms					1212:1216	both dimeric and monomeric forms	1185:1216	both dimeric and monomeric forms	1185:1216	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	9	94	theme	wounds	2022:2027	arg1	treatment					1995:2003	photodynamic treatment	1982:2003	photodynamic treatment of MRSA-infected wounds	1982:2027	These results suggest that films are biocompatible and have potential application in photodynamic treatment of MRSA-infected wounds.
32767164	5	95	theme	spectroscopic	1069:1081	arg1	studies					1083:1089	Absorption spectroscopic studies	1058:1089	Absorption spectroscopic studies of PS-embedded films	1058:1110	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	2	96	theme	infected	453:460	arg1	site					462:465	the infected site	449:465	the infected site in a suitable formulation	449:491	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	5	97	theme	monomeric	1202:1210	arg1	forms					1212:1216	both dimeric and monomeric forms	1185:1216	both dimeric and monomeric forms	1185:1216	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	6	98	theme	MB	1296:1297	arg1	uptake					1278:1283	substantial uptake	1266:1283	substantial uptake of Cp6 and MB	1266:1297	MRSA incubated with the film for 1 h displayed substantial uptake of Cp6 and MB as indicated by the presence of Cp6 fluorescence and MB staining in cells under the microscope.
32767164	7	99	theme	photodynamic	1408:1419	arg1	treatment					1421:1429	photodynamic treatment	1408:1429	photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6	1408:1494	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	5	100	theme	light	937:941	arg1	transmission					943:954	~ 55% light transmission	931:954	~ 55% light transmission in 500 to 750 nm region	931:978	Films containing 1% CMC (15 mm diameter; 110 ± 09 μm thickness) showed ~ 55% light transmission in 500 to 750 nm region and high swelling rate as indicated by ~ 38% increase in diameter within 1 h. Absorption spectroscopic studies of PS-embedded films revealed that while Cp6 existed mainly in monomeric state, MB existed in both dimeric and monomeric forms.
32767164	8	101	from	Studies	1650:1656	arg1	cells					1688:1692	human keratinocyte (HaCaT) cells	1661:1692	human keratinocyte (HaCaT) cells	1661:1692	Studies on human keratinocyte (HaCaT) cells showed that there was no significant change in the viability of cells when they were incubated with solubilized films (plain) for 24 h or subjected to treatment with PS-containing films followed by PDT.
32767164	0	102	theme	composite	104:112	arg1	films					125:129	photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films	39:129	photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films	39:129	Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films.
32767164	7	103	theme	~	1639:1639	arg1	MB					1635:1636	free MB	1630:1636	free MB (~ 6 logs)	1630:1647	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	7	103	theme	~	1639:1639	arg1	logs					1643:1646	~ 6 logs	1639:1646	~ 6 logs	1639:1646	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	7	104	theme	free	1630:1633	arg1	MB					1635:1636	free MB	1630:1636	free MB (~ 6 logs)	1630:1647	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	7	104	theme	free	1630:1633	arg1	logs					1643:1646	~ 6 logs	1639:1646	~ 6 logs	1639:1646	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	7	105	from	decrease	1565:1572	arg1	cfu					1577:1579	cfu	1577:1579	cfu	1577:1579	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	2	106	theme	suitable	472:479	arg1	formulation					481:491	a suitable formulation	470:491	a suitable formulation	470:491	In this approach, delivery of appropriate concentration of photosensitizer (PS) at the infected site is a critical step; it is therefore essential that PS need to be administered at the infected site in a suitable formulation.
32767164	6	107	theme	MB	1352:1353	arg1	staining					1355:1362	MB staining	1352:1362	MB staining	1352:1362	MRSA incubated with the film for 1 h displayed substantial uptake of Cp6 and MB as indicated by the presence of Cp6 fluorescence and MB staining in cells under the microscope.
32767164	6	108	from	fluorescence	1335:1346	arg1	cells					1367:1371	cells	1367:1371	cells under the microscope	1367:1392	MRSA incubated with the film for 1 h displayed substantial uptake of Cp6 and MB as indicated by the presence of Cp6 fluorescence and MB staining in cells under the microscope.
32767164	7	109	theme	MB-embedded	1604:1614	arg1	film					1616:1619	MB-embedded film	1604:1619	MB-embedded film	1604:1619	Furthermore, photodynamic treatment (660 nm, 10 J/cm2) of MRSA with Cp6 embedded in film or free Cp6 resulted in ~ 3 log reduction in colony-forming units (cfu), whereas decrease in cfu was less (~ 1 log) for MB-embedded film than for free MB (~ 6 logs).
32767164	8	110	theme	PS-containing	1860:1872	arg1	films					1874:1878	PS-containing films	1860:1878	PS-containing films	1860:1878	Studies on human keratinocyte (HaCaT) cells showed that there was no significant change in the viability of cells when they were incubated with solubilized films (plain) for 24 h or subjected to treatment with PS-containing films followed by PDT.
32767164	4	111	theme	Sodium	684:689	arg1	SA					701:702	SA	701:702	SA	701:702	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	4	111	theme	Sodium	684:689	arg1	alginate					691:698	Sodium alginate	684:698	Sodium alginate (SA)	684:703	Sodium alginate (SA), pectin (PC), and carboxymethyl cellulose (CMC) were used for preparing films containing chlorin p6 (Cp6, anionic PS) or methylene blue (MB, cationic PS).
32767164	3	112	theme	biopolymer	547:556	arg1	films					558:562	PS-embedded composite biopolymer films	525:562	PS-embedded composite biopolymer films	525:562	Here, we report preparation of PS-embedded composite biopolymer films and their photobactericidal properties against methicillin-resistant Staphylococcus aureus (MRSA) and biocompatibility.
32767164	6	113	theme	fluorescence	1335:1346	arg1	presence					1319:1326	the presence	1315:1326	the presence of Cp6 fluorescence and MB staining in cells under the microscope	1315:1392	MRSA incubated with the film for 1 h displayed substantial uptake of Cp6 and MB as indicated by the presence of Cp6 fluorescence and MB staining in cells under the microscope.
34391099	2	0	theme	environment	487:497	arg1	effects					462:468	the destructive effects	446:468	the destructive effects of their ambient environment	446:497	We prepared a GO-COS complex to adsorb An and protect them from the destructive effects of their ambient environment.
34391099	7	1	theme	tested	1150:1155	arg1	range					1162:1166	the tested dose range	1146:1166	the tested dose range	1146:1166	The complex inhibited HepG2 cell proliferation at the tested dose range.
34391099	4	2	theme	pH	684:685	arg1	method					700:705	the pH differential method	680:705	the pH differential method	680:705	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	8	3	theme	products	1235:1242	arg1	stability					1214:1222	stability	1214:1222	stability of An-rich products	1214:1242	This study provides valuable information for stability of An-rich products.
34391099	2	4	theme	ambient	479:485	arg1	environment					487:497	their ambient environment	473:497	their ambient environment	473:497	We prepared a GO-COS complex to adsorb An and protect them from the destructive effects of their ambient environment.
34391099	1	5	dep	anthocyanins	285:296	arg1	An					299:300	An	299:300	An	299:300	In this study, we tested the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process.
34391099	7	6	theme	dose	1157:1160	arg1	range					1162:1166	the tested dose range	1146:1166	the tested dose range	1146:1166	The complex inhibited HepG2 cell proliferation at the tested dose range.
34391099	8	7	theme	valuable	1189:1196	arg1	information					1198:1208	valuable information	1189:1208	valuable information for stability of An-rich products	1189:1242	This study provides valuable information for stability of An-rich products.
34391099	0	8	from	Effects	0:6	arg1	activity					113:120	antioxidant activity	101:120	antioxidant activity	101:120	Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins.
34391099	0	8	from	Effects	0:6	arg1	stability					65:73	stability	65:73	stability	65:73	Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins.
34391099	0	8	from	Effects	0:6	arg1	digestion					86:94	simulated digestion	76:94	simulated digestion	76:94	Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins.
34391099	4	9	dep	content	618:624	arg1	An					615:616	An	615:616	An	615:616	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	3	10	theme	temperature	543:553	arg1	conditions					590:599	various temperature, pH, light, oxidant, and reductant conditions	535:599	various temperature, pH, light, oxidant, and reductant conditions	535:599	The complex protected the An under various temperature, pH, light, oxidant, and reductant conditions.
34391099	0	11	theme	antioxidant	101:111	arg1	activity					113:120	antioxidant activity	101:120	antioxidant activity	101:120	Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins.
34391099	1	12	theme	digestive	363:371	arg1	process					373:379	the digestive process	359:379	the digestive process	359:379	In this study, we tested the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process.
34391099	1	13	theme	blueberry	275:283	arg1	anthocyanins					285:296	blueberry anthocyanins	275:296	blueberry anthocyanins (An)	275:301	In this study, we tested the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process.
34391099	0	14	theme	blueberry	125:133	arg1	anthocyanins					135:146	blueberry anthocyanins	125:146	blueberry anthocyanins	125:146	Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins.
34391099	7	15	theme	cell	1124:1127	arg1	proliferation					1129:1141	HepG2 cell proliferation	1118:1141	HepG2 cell proliferation	1118:1141	The complex inhibited HepG2 cell proliferation at the tested dose range.
34391099	4	16	theme	performance	720:730	arg1	HPLC-MS					773:779	HPLC-MS	773:779	HPLC-MS	773:779	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	4	16	theme	performance	720:730	arg1	spectrometry					759:770	the high performance liquid chromatography-mass spectrometry	711:770	the high performance liquid chromatography-mass spectrometry (HPLC-MS)	711:780	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	8	17	theme	An-rich	1227:1233	arg1	products					1235:1242	An-rich products	1227:1242	An-rich products	1227:1242	This study provides valuable information for stability of An-rich products.
34391099	5	18	theme	peroxyl	853:859	arg1	capacity					880:887	their peroxyl radical-scavenging capacity	847:887	their peroxyl radical-scavenging capacity	847:887	The GO-COS carrier stabilized An in the intestine and protected their peroxyl radical-scavenging capacity.
34391099	6	19	theme	simultaneous	1003:1014	arg1	improvement					1016:1026	simultaneous improvement	1003:1026	simultaneous improvement of An bioavailability when the An	1003:1060	Additionally, we observed a dose-response relationship between An content and cellular antioxidant activity, and simultaneous improvement of An bioavailability when the An were encapsulated in the complex.
34391099	3	20	theme	various	535:541	arg1	temperature					543:553	various temperature	535:553	various temperature	535:553	The complex protected the An under various temperature, pH, light, oxidant, and reductant conditions.
34391099	1	21	theme	in	178:179	arg1	efficacy					187:194	the in vitro efficacy	174:194	the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process	174:379	In this study, we tested the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process.
34391099	3	22	theme	light	560:564	arg1	conditions					590:599	various temperature, pH, light, oxidant, and reductant conditions	535:599	various temperature, pH, light, oxidant, and reductant conditions	535:599	The complex protected the An under various temperature, pH, light, oxidant, and reductant conditions.
34391099	4	23	theme	digestive	657:665	arg1	system					667:672	a simulated digestive system	645:672	a simulated digestive system using the pH differential method	645:705	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	6	24	theme	dose-response	918:930	arg1	relationship					932:943	a dose-response relationship	916:943	a dose-response relationship between An content and cellular antioxidant activity	916:996	Additionally, we observed a dose-response relationship between An content and cellular antioxidant activity, and simultaneous improvement of An bioavailability when the An were encapsulated in the complex.
34391099	7	25	theme	HepG2	1118:1122	arg1	proliferation					1129:1141	HepG2 cell proliferation	1118:1141	HepG2 cell proliferation	1118:1141	The complex inhibited HepG2 cell proliferation at the tested dose range.
34391099	4	26	theme	high	715:718	arg1	HPLC-MS					773:779	HPLC-MS	773:779	HPLC-MS	773:779	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	4	26	theme	high	715:718	arg1	spectrometry					759:770	the high performance liquid chromatography-mass spectrometry	711:770	the high performance liquid chromatography-mass spectrometry (HPLC-MS)	711:780	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	4	27	from	composition	630:640	arg1	system					667:672	a simulated digestive system	645:672	a simulated digestive system using the pH differential method	645:705	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	4	28	theme	simulated	647:655	arg1	system					667:672	a simulated digestive system	645:672	a simulated digestive system using the pH differential method	645:705	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	0	29	theme	graphene	47:54	arg1	oxide					56:60	chitooligosaccharide-functionalized graphene oxide	11:60	chitooligosaccharide-functionalized graphene oxide	11:60	Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins.
34391099	4	30	from	spectrometry	759:770	arg1	system					667:672	a simulated digestive system	645:672	a simulated digestive system using the pH differential method	645:705	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	3	31	theme	pH	556:557	arg1	conditions					590:599	various temperature, pH, light, oxidant, and reductant conditions	535:599	various temperature, pH, light, oxidant, and reductant conditions	535:599	The complex protected the An under various temperature, pH, light, oxidant, and reductant conditions.
34391099	0	32	theme	chitooligosaccharide-functionalized	11:45	arg1	oxide					56:60	chitooligosaccharide-functionalized graphene oxide	11:60	chitooligosaccharide-functionalized graphene oxide	11:60	Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins.
34391099	0	33	theme	anthocyanins	135:146	arg1	activity					113:120	antioxidant activity	101:120	antioxidant activity	101:120	Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins.
34391099	0	33	theme	anthocyanins	135:146	arg1	stability					65:73	stability	65:73	stability	65:73	Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins.
34391099	0	33	theme	anthocyanins	135:146	arg1	digestion					86:94	simulated digestion	76:94	simulated digestion	76:94	Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins.
34391099	4	34	theme	liquid	732:737	arg1	HPLC-MS					773:779	HPLC-MS	773:779	HPLC-MS	773:779	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	4	34	theme	liquid	732:737	arg1	spectrometry					759:770	the high performance liquid chromatography-mass spectrometry	711:770	the high performance liquid chromatography-mass spectrometry (HPLC-MS)	711:780	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	4	35	from	content	618:624	arg1	system					667:672	a simulated digestive system	645:672	a simulated digestive system using the pH differential method	645:705	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	5	36	theme	radical-scavenging	861:878	arg1	capacity					880:887	their peroxyl radical-scavenging capacity	847:887	their peroxyl radical-scavenging capacity	847:887	The GO-COS carrier stabilized An in the intestine and protected their peroxyl radical-scavenging capacity.
34391099	6	37	theme	antioxidant	977:987	arg1	activity					989:996	cellular antioxidant activity	968:996	cellular antioxidant activity	968:996	Additionally, we observed a dose-response relationship between An content and cellular antioxidant activity, and simultaneous improvement of An bioavailability when the An were encapsulated in the complex.
34391099	1	38	theme	graphene	201:208	arg1	complex					246:252	a graphene oxide-chitooligosaccharide (GO-COS) complex	199:252	a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process	199:379	In this study, we tested the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process.
34391099	0	39	theme	oxide	56:60	arg1	Effects					0:6	Effects	0:6	Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins	0:146	Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins.
34391099	6	40	theme	cellular	968:975	arg1	activity					989:996	cellular antioxidant activity	968:996	cellular antioxidant activity	968:996	Additionally, we observed a dose-response relationship between An content and cellular antioxidant activity, and simultaneous improvement of An bioavailability when the An were encapsulated in the complex.
34391099	3	41	theme	reductant	580:588	arg1	conditions					590:599	various temperature, pH, light, oxidant, and reductant conditions	535:599	various temperature, pH, light, oxidant, and reductant conditions	535:599	The complex protected the An under various temperature, pH, light, oxidant, and reductant conditions.
34391099	1	42	theme	oxide-chitooligosaccharide	210:235	arg1	complex					246:252	a graphene oxide-chitooligosaccharide (GO-COS) complex	199:252	a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process	199:379	In this study, we tested the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process.
34391099	5	43	theme	GO-COS	787:792	arg1	carrier					794:800	The GO-COS carrier	783:800	The GO-COS carrier	783:800	The GO-COS carrier stabilized An in the intestine and protected their peroxyl radical-scavenging capacity.
34391099	3	44	theme	oxidant	567:573	arg1	conditions					590:599	various temperature, pH, light, oxidant, and reductant conditions	535:599	various temperature, pH, light, oxidant, and reductant conditions	535:599	The complex protected the An under various temperature, pH, light, oxidant, and reductant conditions.
34391099	2	45	theme	destructive	450:460	arg1	effects					462:468	the destructive effects	446:468	the destructive effects of their ambient environment	446:497	We prepared a GO-COS complex to adsorb An and protect them from the destructive effects of their ambient environment.
34391099	1	46	dep	in	178:179	arg1	vitro					181:185	vitro	181:185	vitro	181:185	In this study, we tested the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process.
34391099	4	47	theme	differential	687:698	arg1	method					700:705	the pH differential method	680:705	the pH differential method	680:705	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	1	48	theme	various	323:329	arg1	factors					347:353	various physicochemical factors	323:353	various physicochemical factors	323:353	In this study, we tested the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process.
34391099	4	49	theme	chromatography-mass	739:757	arg1	HPLC-MS					773:779	HPLC-MS	773:779	HPLC-MS	773:779	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	4	49	theme	chromatography-mass	739:757	arg1	spectrometry					759:770	the high performance liquid chromatography-mass spectrometry	711:770	the high performance liquid chromatography-mass spectrometry (HPLC-MS)	711:780	We evaluated An content and composition in a simulated digestive system using the pH differential method and the high performance liquid chromatography-mass spectrometry (HPLC-MS).
34391099	1	50	theme	GO-COS	238:243	arg1	complex					246:252	a graphene oxide-chitooligosaccharide (GO-COS) complex	199:252	a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process	199:379	In this study, we tested the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process.
34391099	2	51	theme	GO-COS	396:401	arg1	complex					403:409	a GO-COS complex	394:409	a GO-COS complex	394:409	We prepared a GO-COS complex to adsorb An and protect them from the destructive effects of their ambient environment.
34391099	0	52	theme	simulated	76:84	arg1	digestion					86:94	simulated digestion	76:94	simulated digestion	76:94	Effects of chitooligosaccharide-functionalized graphene oxide on stability, simulated digestion, and antioxidant activity of blueberry anthocyanins.
34391099	1	53	theme	physicochemical	331:345	arg1	factors					347:353	various physicochemical factors	323:353	various physicochemical factors	323:353	In this study, we tested the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process.
34391099	6	54	theme	bioavailability	1034:1048	arg1	improvement					1016:1026	simultaneous improvement	1003:1026	simultaneous improvement of An bioavailability when the An	1003:1060	Additionally, we observed a dose-response relationship between An content and cellular antioxidant activity, and simultaneous improvement of An bioavailability when the An were encapsulated in the complex.
34391099	1	55	theme	complex	246:252	arg1	efficacy					187:194	the in vitro efficacy	174:194	the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process	174:379	In this study, we tested the in vitro efficacy of a graphene oxide-chitooligosaccharide (GO-COS) complex developed to protect blueberry anthocyanins (An) from degradation by various physicochemical factors and the digestive process.
33135689	5	0	theme	overall	946:952	arg1	composition					963:973	overall cellular composition	946:973	overall cellular composition	946:973	To understand the variation within peptidoglycan, the overall structure must be broken down into its constitutive parts (known as muropeptides) and assessed for overall cellular composition.
33135689	4	1	theme	dynamic	632:638	arg1	structure					640:648	a highly dynamic structure	623:648	a highly dynamic structure that is known to participate in many cellular functions, including growth/division, antibiotic resistance, and host defense avoidance	623:782	These variations produce a highly dynamic structure that is known to participate in many cellular functions, including growth/division, antibiotic resistance, and host defense avoidance.
33135689	1	2	theme	common	177:182	arg1	target					193:198	a common cellular target	175:198	a common cellular target for antimicrobials	175:217	Peptidoglycan is an important component of bacterial cell walls and a common cellular target for antimicrobials.
33135689	3	3	dep	phase	562:566	arg1	response					543:550	response	543:550	response	543:550	In addition, there are numerous known variations, modifications, or adaptations to the peptidoglycan that can occur within a bacterial species in response to growth phase and/or environmental stimuli.
33135689	7	4	theme	differential	1329:1340	arg1	analysis					1342:1349	the differential analysis	1325:1349	the differential analysis of peptidoglycan composition using bioinformatics	1325:1399	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	7	5	theme	data	1266:1269	arg1	acquisition					1229:1239	the acquisition	1225:1239	the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer	1225:1318	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	7	5	theme	data	1266:1269	arg1	purification					1170:1181	the purification	1166:1181	the purification of peptidoglycan from bacterial cultures	1166:1222	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	7	5	theme	data	1266:1269	arg1	analysis					1342:1349	the differential analysis	1325:1349	the differential analysis of peptidoglycan composition using bioinformatics	1325:1399	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	3	6	theme	bacterial	522:530	arg1	species					532:538	a bacterial species	520:538	a bacterial species	520:538	In addition, there are numerous known variations, modifications, or adaptations to the peptidoglycan that can occur within a bacterial species in response to growth phase and/or environmental stimuli.
33135689	7	7	theme	liquid	1281:1286	arg1	spectrometer					1307:1318	a liquid chromatograph-mass spectrometer	1279:1318	a liquid chromatograph-mass spectrometer	1279:1318	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	1	8	theme	cellular	184:191	arg1	target					193:198	a common cellular target	175:198	a common cellular target for antimicrobials	175:217	Peptidoglycan is an important component of bacterial cell walls and a common cellular target for antimicrobials.
33135689	7	9	theme	intensity	1256:1264	arg1	data					1266:1269	muropeptide intensity data	1244:1269	muropeptide intensity data	1244:1269	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	5	10	theme	cellular	954:961	arg1	composition					963:973	overall cellular composition	946:973	overall cellular composition	946:973	To understand the variation within peptidoglycan, the overall structure must be broken down into its constitutive parts (known as muropeptides) and assessed for overall cellular composition.
33135689	5	11	theme	overall	839:845	arg1	structure					847:855	the overall structure	835:855	the overall structure	835:855	To understand the variation within peptidoglycan, the overall structure must be broken down into its constitutive parts (known as muropeptides) and assessed for overall cellular composition.
33135689	3	12	theme	environmental	575:587	arg1	stimuli					589:595	environmental stimuli	575:595	environmental stimuli	575:595	In addition, there are numerous known variations, modifications, or adaptations to the peptidoglycan that can occur within a bacterial species in response to growth phase and/or environmental stimuli.
33135689	3	13	theme	known	429:433	arg1	variations					435:444	numerous known variations	420:444	numerous known variations	420:444	In addition, there are numerous known variations, modifications, or adaptations to the peptidoglycan that can occur within a bacterial species in response to growth phase and/or environmental stimuli.
33135689	7	14	theme	peptidoglycan	1186:1198	arg1	acquisition					1229:1239	the acquisition	1225:1239	the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer	1225:1318	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	7	14	theme	peptidoglycan	1186:1198	arg1	purification					1170:1181	the purification	1166:1181	the purification of peptidoglycan from bacterial cultures	1166:1222	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	7	14	theme	peptidoglycan	1186:1198	arg1	analysis					1342:1349	the differential analysis	1325:1349	the differential analysis of peptidoglycan composition using bioinformatics	1325:1399	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	7	15	theme	chromatograph-mass	1288:1305	arg1	spectrometer					1307:1318	a liquid chromatograph-mass spectrometer	1279:1318	a liquid chromatograph-mass spectrometer	1279:1318	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	0	16	theme	Semi-Quantitative	0:16	arg1	Analysis					18:25	Semi-Quantitative Analysis	0:25	Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics.	0:105	Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics.
33135689	6	17	theme	data	1066:1069	arg1	analysis					1071:1078	high-powered bioinformatic data analysis	1039:1078	high-powered bioinformatic data analysis	1039:1078	Peptidoglycomics uses advanced mass spectrometry combined with high-powered bioinformatic data analysis to examine peptidoglycan composition in fine detail.
33135689	7	18	theme	bacterial	1205:1213	arg1	cultures					1215:1222	bacterial cultures	1205:1222	bacterial cultures	1205:1222	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	6	19	theme	peptidoglycan	1091:1103	arg1	composition					1105:1115	peptidoglycan composition	1091:1115	peptidoglycan composition	1091:1115	Peptidoglycomics uses advanced mass spectrometry combined with high-powered bioinformatic data analysis to examine peptidoglycan composition in fine detail.
33135689	0	20	theme	Peptidoglycan	30:42	arg1	Analysis					18:25	Semi-Quantitative Analysis	0:25	Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics.	0:105	Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics.
33135689	6	21	theme	bioinformatic	1052:1064	arg1	analysis					1071:1078	high-powered bioinformatic data analysis	1039:1078	high-powered bioinformatic data analysis	1039:1078	Peptidoglycomics uses advanced mass spectrometry combined with high-powered bioinformatic data analysis to examine peptidoglycan composition in fine detail.
33135689	4	22	theme	many	682:685	arg1	avoidance					774:782	host defense avoidance	761:782	host defense avoidance	761:782	These variations produce a highly dynamic structure that is known to participate in many cellular functions, including growth/division, antibiotic resistance, and host defense avoidance.
33135689	4	22	theme	many	682:685	arg1	functions					696:704	many cellular functions	682:704	many cellular functions	682:704	These variations produce a highly dynamic structure that is known to participate in many cellular functions, including growth/division, antibiotic resistance, and host defense avoidance.
33135689	4	22	theme	many	682:685	arg1	growth/division					717:731	growth/division	717:731	growth/division	717:731	These variations produce a highly dynamic structure that is known to participate in many cellular functions, including growth/division, antibiotic resistance, and host defense avoidance.
33135689	4	22	theme	many	682:685	arg1	resistance					745:754	antibiotic resistance	734:754	antibiotic resistance	734:754	These variations produce a highly dynamic structure that is known to participate in many cellular functions, including growth/division, antibiotic resistance, and host defense avoidance.
33135689	3	23	theme	numerous	420:427	arg1	variations					435:444	numerous known variations	420:444	numerous known variations	420:444	In addition, there are numerous known variations, modifications, or adaptations to the peptidoglycan that can occur within a bacterial species in response to growth phase and/or environmental stimuli.
33135689	6	24	theme	high-powered	1039:1050	arg1	analysis					1071:1078	high-powered bioinformatic data analysis	1039:1078	high-powered bioinformatic data analysis	1039:1078	Peptidoglycomics uses advanced mass spectrometry combined with high-powered bioinformatic data analysis to examine peptidoglycan composition in fine detail.
33135689	1	25	theme	important	127:135	arg1	component					137:145	an important component	124:145	an important component of bacterial cell walls	124:169	Peptidoglycan is an important component of bacterial cell walls and a common cellular target for antimicrobials.
33135689	1	25	theme	important	127:135	arg1	Peptidoglycan					107:119	Peptidoglycan	107:119	Peptidoglycan	107:119	Peptidoglycan is an important component of bacterial cell walls and a common cellular target for antimicrobials.
33135689	1	26	theme	walls	165:169	arg1	component					137:145	an important component	124:145	an important component of bacterial cell walls	124:169	Peptidoglycan is an important component of bacterial cell walls and a common cellular target for antimicrobials.
33135689	1	26	theme	walls	165:169	arg1	target					193:198	a common cellular target	175:198	a common cellular target for antimicrobials	175:217	Peptidoglycan is an important component of bacterial cell walls and a common cellular target for antimicrobials.
33135689	1	26	theme	walls	165:169	arg1	Peptidoglycan					107:119	Peptidoglycan	107:119	Peptidoglycan	107:119	Peptidoglycan is an important component of bacterial cell walls and a common cellular target for antimicrobials.
33135689	0	27	theme	Liquid	47:52	arg1	Spectrometry					74:85	Liquid Chromatography Mass Spectrometry	47:85	Liquid Chromatography Mass Spectrometry	47:85	Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics.
33135689	7	28	from	cultures	1215:1222	arg1	acquisition					1229:1239	the acquisition	1225:1239	the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer	1225:1318	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	7	28	from	cultures	1215:1222	arg1	purification					1170:1181	the purification	1166:1181	the purification of peptidoglycan from bacterial cultures	1166:1222	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	7	28	from	cultures	1215:1222	arg1	analysis					1342:1349	the differential analysis	1325:1349	the differential analysis of peptidoglycan composition using bioinformatics	1325:1399	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	7	29	theme	muropeptide	1244:1254	arg1	data					1266:1269	muropeptide intensity data	1244:1269	muropeptide intensity data	1244:1269	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	4	30	theme	cellular	687:694	arg1	avoidance					774:782	host defense avoidance	761:782	host defense avoidance	761:782	These variations produce a highly dynamic structure that is known to participate in many cellular functions, including growth/division, antibiotic resistance, and host defense avoidance.
33135689	4	30	theme	cellular	687:694	arg1	functions					696:704	many cellular functions	682:704	many cellular functions	682:704	These variations produce a highly dynamic structure that is known to participate in many cellular functions, including growth/division, antibiotic resistance, and host defense avoidance.
33135689	4	30	theme	cellular	687:694	arg1	growth/division					717:731	growth/division	717:731	growth/division	717:731	These variations produce a highly dynamic structure that is known to participate in many cellular functions, including growth/division, antibiotic resistance, and host defense avoidance.
33135689	4	30	theme	cellular	687:694	arg1	resistance					745:754	antibiotic resistance	734:754	antibiotic resistance	734:754	These variations produce a highly dynamic structure that is known to participate in many cellular functions, including growth/division, antibiotic resistance, and host defense avoidance.
33135689	0	31	theme	Mass	69:72	arg1	Spectrometry					74:85	Liquid Chromatography Mass Spectrometry	47:85	Liquid Chromatography Mass Spectrometry	47:85	Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics.
33135689	7	32	theme	following	1137:1145	arg1	protocol					1147:1154	The following protocol	1133:1154	The following protocol	1133:1154	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	2	33	theme	structure	254:262	arg1	aspects					229:235	aspects	229:235	aspects of peptidoglycan structure	229:262	Although aspects of peptidoglycan structure are fairly conserved across all bacteria, there is also considerable variation between Gram-positives/negatives and between species.
33135689	4	34	theme	defense	766:772	arg1	avoidance					774:782	host defense avoidance	761:782	host defense avoidance	761:782	These variations produce a highly dynamic structure that is known to participate in many cellular functions, including growth/division, antibiotic resistance, and host defense avoidance.
33135689	0	35	theme	Chromatography	54:67	arg1	Spectrometry					74:85	Liquid Chromatography Mass Spectrometry	47:85	Liquid Chromatography Mass Spectrometry	47:85	Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics.
33135689	6	36	theme	mass	1007:1010	arg1	spectrometry					1012:1023	advanced mass spectrometry	998:1023	advanced mass spectrometry combined with high-powered bioinformatic data analysis	998:1078	Peptidoglycomics uses advanced mass spectrometry combined with high-powered bioinformatic data analysis to examine peptidoglycan composition in fine detail.
33135689	2	37	theme	peptidoglycan	240:252	arg1	structure					254:262	peptidoglycan structure	240:262	peptidoglycan structure	240:262	Although aspects of peptidoglycan structure are fairly conserved across all bacteria, there is also considerable variation between Gram-positives/negatives and between species.
33135689	4	38	theme	host	761:764	arg1	avoidance					774:782	host defense avoidance	761:782	host defense avoidance	761:782	These variations produce a highly dynamic structure that is known to participate in many cellular functions, including growth/division, antibiotic resistance, and host defense avoidance.
33135689	2	39	theme	considerable	320:331	arg1	variation					333:341	considerable variation	320:341	considerable variation between Gram-positives/negatives and between species	320:394	Although aspects of peptidoglycan structure are fairly conserved across all bacteria, there is also considerable variation between Gram-positives/negatives and between species.
33135689	6	40	theme	advanced	998:1005	arg1	spectrometry					1012:1023	advanced mass spectrometry	998:1023	advanced mass spectrometry combined with high-powered bioinformatic data analysis	998:1078	Peptidoglycomics uses advanced mass spectrometry combined with high-powered bioinformatic data analysis to examine peptidoglycan composition in fine detail.
33135689	1	41	theme	bacterial	150:158	arg1	walls					165:169	bacterial cell walls	150:169	bacterial cell walls	150:169	Peptidoglycan is an important component of bacterial cell walls and a common cellular target for antimicrobials.
33135689	1	42	theme	cell	160:163	arg1	walls					165:169	bacterial cell walls	150:169	bacterial cell walls	150:169	Peptidoglycan is an important component of bacterial cell walls and a common cellular target for antimicrobials.
33135689	6	43	theme	fine	1120:1123	arg1	detail					1125:1130	fine detail	1120:1130	fine detail	1120:1130	Peptidoglycomics uses advanced mass spectrometry combined with high-powered bioinformatic data analysis to examine peptidoglycan composition in fine detail.
33135689	7	44	theme	peptidoglycan	1354:1366	arg1	composition					1368:1378	peptidoglycan composition	1354:1378	peptidoglycan composition using bioinformatics	1354:1399	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	5	45	theme	constitutive	886:897	arg1	parts					899:903	its constitutive parts	882:903	its constitutive parts (known as muropeptides)	882:927	To understand the variation within peptidoglycan, the overall structure must be broken down into its constitutive parts (known as muropeptides) and assessed for overall cellular composition.
33135689	3	46	theme	growth	555:560	arg1	phase					562:566	growth phase	555:566	growth phase	555:566	In addition, there are numerous known variations, modifications, or adaptations to the peptidoglycan that can occur within a bacterial species in response to growth phase and/or environmental stimuli.
33135689	7	47	theme	composition	1368:1378	arg1	acquisition					1229:1239	the acquisition	1225:1239	the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer	1225:1318	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	7	47	theme	composition	1368:1378	arg1	purification					1170:1181	the purification	1166:1181	the purification of peptidoglycan from bacterial cultures	1166:1222	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	7	47	theme	composition	1368:1378	arg1	analysis					1342:1349	the differential analysis	1325:1349	the differential analysis of peptidoglycan composition using bioinformatics	1325:1399	The following protocol describes the purification of peptidoglycan from bacterial cultures, the acquisition of muropeptide intensity data through a liquid chromatograph-mass spectrometer, and the differential analysis of peptidoglycan composition using bioinformatics.
33135689	5	48	dep	parts	899:903	arg1	known					906:910	known	906:910	known as muropeptides	906:926	To understand the variation within peptidoglycan, the overall structure must be broken down into its constitutive parts (known as muropeptides) and assessed for overall cellular composition.
33135689	4	49	theme	antibiotic	734:743	arg1	resistance					745:754	antibiotic resistance	734:754	antibiotic resistance	734:754	These variations produce a highly dynamic structure that is known to participate in many cellular functions, including growth/division, antibiotic resistance, and host defense avoidance.
32469014	9	0	theme	HCT116	1154:1159	arg1	cells					1161:1165	HCT116 cells	1154:1165	HCT116 cells	1154:1165	The presence of CS improved the antiproliferative activity of curcumin-loaded zein nanoparticles (Cur-ZNPs) to HCT116 cells.
32469014	0	1	theme	curcumin	77:84	arg1	vehicles					65:72	delivery vehicles	56:72	delivery vehicles of curcumin	56:84	Self-assembled composite nanoparticles based on zein as delivery vehicles of curcumin: role of chondroitin sulfate.
32469014	4	2	theme	encapsulation	503:515	arg1	efficiency					517:526	The encapsulation efficiency	499:526	The encapsulation efficiency of curcumin	499:538	The encapsulation efficiency of curcumin was enhanced by CS and showed the maximum (91.97%) when the mass ratio of zein-to-CS was 1 : 1 (ZCCNPs1:1).
32469014	1	3	theme	chondroitin	161:171	arg1	CS					182:183	CS	182:183	CS	182:183	Composite nanoparticles composed of zein and chondroitin sulfate (CS) were self-assembled by the method of antisolvent precipitation to deliver curcumin (ZCCNPs).
32469014	1	3	theme	chondroitin	161:171	arg1	sulfate					173:179	chondroitin sulfate	161:179	chondroitin sulfate (CS)	161:184	Composite nanoparticles composed of zein and chondroitin sulfate (CS) were self-assembled by the method of antisolvent precipitation to deliver curcumin (ZCCNPs).
32469014	5	4	theme	curcumin	669:676	arg1	crystallinity					652:664	The crystallinity	648:664	The crystallinity of curcumin	648:676	The crystallinity of curcumin changed to amorphous in ZCCNPs1:1.
32469014	11	5	theme	cytotoxicity	1321:1332	arg1	assay					1334:1338	in vitro cytotoxicity assay	1312:1338	in vitro cytotoxicity assay on NCM460 cells	1312:1354	In addition, ZCCNPs1:1 exhibited excellent biocompatibility evaluated using in vitro cytotoxicity assay on NCM460 cells.
32469014	0	6	theme	sulfate	107:113	arg1	role					87:90	role	87:90	role of chondroitin sulfate	87:113	Self-assembled composite nanoparticles based on zein as delivery vehicles of curcumin: role of chondroitin sulfate.
32469014	2	7	theme	hydrogen	378:385	arg1	bonding					387:393	hydrogen bonding	378:393	hydrogen bonding	378:393	The structure of ZCCNPs changed from spheres to microaggregates with the increase of CS, involving hydrogen bonding and electrostatic and hydrophobic effects.
32469014	0	8	theme	chondroitin	95:105	arg1	sulfate					107:113	chondroitin sulfate	95:113	chondroitin sulfate	95:113	Self-assembled composite nanoparticles based on zein as delivery vehicles of curcumin: role of chondroitin sulfate.
32469014	9	9	theme	CS	1059:1060	arg1	presence					1047:1054	The presence	1043:1054	The presence of CS	1043:1060	The presence of CS improved the antiproliferative activity of curcumin-loaded zein nanoparticles (Cur-ZNPs) to HCT116 cells.
32469014	11	10	from	assay	1334:1338	arg1	cells					1350:1354	NCM460 cells	1343:1354	NCM460 cells	1343:1354	In addition, ZCCNPs1:1 exhibited excellent biocompatibility evaluated using in vitro cytotoxicity assay on NCM460 cells.
32469014	11	11	theme	in	1312:1313	arg1	assay					1334:1338	in vitro cytotoxicity assay	1312:1338	in vitro cytotoxicity assay on NCM460 cells	1312:1354	In addition, ZCCNPs1:1 exhibited excellent biocompatibility evaluated using in vitro cytotoxicity assay on NCM460 cells.
32469014	4	12	theme	zein-to-CS	614:623	arg1	ratio					605:609	the mass ratio	596:609	the mass ratio of zein-to-CS	596:623	The encapsulation efficiency of curcumin was enhanced by CS and showed the maximum (91.97%) when the mass ratio of zein-to-CS was 1 : 1 (ZCCNPs1:1).
32469014	4	13	dep	enhanced	544:551	arg1	ZCCNPs1:1					636:644	ZCCNPs1:1	636:644	ZCCNPs1:1	636:644	The encapsulation efficiency of curcumin was enhanced by CS and showed the maximum (91.97%) when the mass ratio of zein-to-CS was 1 : 1 (ZCCNPs1:1).
32469014	4	13	dep	enhanced	544:551	arg1	 1					632:633	 1	632:633	 1	632:633	The encapsulation efficiency of curcumin was enhanced by CS and showed the maximum (91.97%) when the mass ratio of zein-to-CS was 1 : 1 (ZCCNPs1:1).
32469014	0	14	theme	Self-assembled	0:13	arg1	composite					15:23	Self-assembled composite	0:23	Self-assembled composite	0:23	Self-assembled composite nanoparticles based on zein as delivery vehicles of curcumin: role of chondroitin sulfate.
32469014	6	15	theme	great	733:737	arg1	stability					739:747	great stability	733:747	great stability	733:747	ZCCNPs1:1 exhibited great stability at pH 3.0-8.0, and it showed excellent thermostability at 35, 55, and 80 °C respectively for 120 min when the pH was 4.0 or 6.0.
32469014	2	16	theme	ZCCNPs	296:301	arg1	structure					283:291	The structure	279:291	The structure of ZCCNPs	279:301	The structure of ZCCNPs changed from spheres to microaggregates with the increase of CS, involving hydrogen bonding and electrostatic and hydrophobic effects.
32469014	11	17	theme	excellent	1269:1277	arg1	biocompatibility					1279:1294	excellent biocompatibility	1269:1294	excellent biocompatibility evaluated using in vitro cytotoxicity assay on NCM460 cells	1269:1354	In addition, ZCCNPs1:1 exhibited excellent biocompatibility evaluated using in vitro cytotoxicity assay on NCM460 cells.
32469014	2	18	theme	CS	364:365	arg1	increase					352:359	the increase	348:359	the increase of CS	348:365	The structure of ZCCNPs changed from spheres to microaggregates with the increase of CS, involving hydrogen bonding and electrostatic and hydrophobic effects.
32469014	12	19	theme	nutrients	1490:1498	arg1	application					1463:1473	the application	1459:1473	the application of hydrophobic nutrients in functional foods	1459:1518	The studies indicate that the delivery system fabricated in our work would be efficient for improving the application of hydrophobic nutrients in functional foods.
32469014	9	20	theme	antiproliferative	1075:1091	arg1	activity					1093:1100	the antiproliferative activity	1071:1100	the antiproliferative activity of curcumin-loaded zein nanoparticles (Cur-ZNPs) to HCT116 cells	1071:1165	The presence of CS improved the antiproliferative activity of curcumin-loaded zein nanoparticles (Cur-ZNPs) to HCT116 cells.
32469014	10	21	theme	higher	1188:1193	arg1	%					1218:1218	42.36%	1213:1218	42.36%	1213:1218	ZCCNPs1:1 exhibited higher bioaccessibility (42.36%) than Cur-ZNPs.
32469014	10	21	theme	higher	1188:1193	arg1	bioaccessibility					1195:1210	higher bioaccessibility	1188:1210	higher bioaccessibility (42.36%)	1188:1219	ZCCNPs1:1 exhibited higher bioaccessibility (42.36%) than Cur-ZNPs.
32469014	4	22	theme	mass	600:603	arg1	ratio					605:609	the mass ratio	596:609	the mass ratio of zein-to-CS	596:623	The encapsulation efficiency of curcumin was enhanced by CS and showed the maximum (91.97%) when the mass ratio of zein-to-CS was 1 : 1 (ZCCNPs1:1).
32469014	2	23	theme	hydrophobic	417:427	arg1	effects					429:435	electrostatic and hydrophobic effects	399:435	electrostatic and hydrophobic effects	399:435	The structure of ZCCNPs changed from spheres to microaggregates with the increase of CS, involving hydrogen bonding and electrostatic and hydrophobic effects.
32469014	12	24	theme	delivery	1387:1394	arg1	efficient					1435:1443	efficient	1435:1443	efficient	1435:1443	The studies indicate that the delivery system fabricated in our work would be efficient for improving the application of hydrophobic nutrients in functional foods.
32469014	12	24	theme	delivery	1387:1394	arg1	system					1396:1401	the delivery system	1383:1401	the delivery system fabricated in our work	1383:1424	The studies indicate that the delivery system fabricated in our work would be efficient for improving the application of hydrophobic nutrients in functional foods.
32469014	2	25	theme	electrostatic	399:411	arg1	effects					429:435	electrostatic and hydrophobic effects	399:435	electrostatic and hydrophobic effects	399:435	The structure of ZCCNPs changed from spheres to microaggregates with the increase of CS, involving hydrogen bonding and electrostatic and hydrophobic effects.
32469014	12	26	theme	functional	1503:1512	arg1	foods					1514:1518	functional foods	1503:1518	functional foods	1503:1518	The studies indicate that the delivery system fabricated in our work would be efficient for improving the application of hydrophobic nutrients in functional foods.
32469014	11	27	theme	NCM460	1343:1348	arg1	cells					1350:1354	NCM460 cells	1343:1354	NCM460 cells	1343:1354	In addition, ZCCNPs1:1 exhibited excellent biocompatibility evaluated using in vitro cytotoxicity assay on NCM460 cells.
32469014	8	28	theme	retention	968:976	arg1	rate					978:981	The retention rate	964:981	The retention rate of curcumin in ZCCNPs1:1	964:1006	The retention rate of curcumin in ZCCNPs1:1 was higher than 65% within 8 days.
32469014	8	28	theme	retention	968:976	arg1	%					1026:1026	higher than 65%	1012:1026	higher than 65%	1012:1026	The retention rate of curcumin in ZCCNPs1:1 was higher than 65% within 8 days.
32469014	9	29	theme	curcumin-loaded	1105:1119	arg1	Cur-ZNPs					1141:1148	Cur-ZNPs	1141:1148	Cur-ZNPs	1141:1148	The presence of CS improved the antiproliferative activity of curcumin-loaded zein nanoparticles (Cur-ZNPs) to HCT116 cells.
32469014	9	29	theme	curcumin-loaded	1105:1119	arg1	nanoparticles					1126:1138	curcumin-loaded zein nanoparticles	1105:1138	curcumin-loaded zein nanoparticles (Cur-ZNPs)	1105:1149	The presence of CS improved the antiproliferative activity of curcumin-loaded zein nanoparticles (Cur-ZNPs) to HCT116 cells.
32469014	11	30	dep	in	1312:1313	arg1	vitro					1315:1319	vitro	1315:1319	vitro	1315:1319	In addition, ZCCNPs1:1 exhibited excellent biocompatibility evaluated using in vitro cytotoxicity assay on NCM460 cells.
32469014	0	31	theme	delivery	56:63	arg1	vehicles					65:72	delivery vehicles	56:72	delivery vehicles of curcumin	56:84	Self-assembled composite nanoparticles based on zein as delivery vehicles of curcumin: role of chondroitin sulfate.
32469014	8	32	theme	curcumin	986:993	arg1	rate					978:981	The retention rate	964:981	The retention rate of curcumin in ZCCNPs1:1	964:1006	The retention rate of curcumin in ZCCNPs1:1 was higher than 65% within 8 days.
32469014	8	32	theme	curcumin	986:993	arg1	%					1026:1026	higher than 65%	1012:1026	higher than 65%	1012:1026	The retention rate of curcumin in ZCCNPs1:1 was higher than 65% within 8 days.
32469014	9	33	theme	zein	1121:1124	arg1	Cur-ZNPs					1141:1148	Cur-ZNPs	1141:1148	Cur-ZNPs	1141:1148	The presence of CS improved the antiproliferative activity of curcumin-loaded zein nanoparticles (Cur-ZNPs) to HCT116 cells.
32469014	9	33	theme	zein	1121:1124	arg1	nanoparticles					1126:1138	curcumin-loaded zein nanoparticles	1105:1138	curcumin-loaded zein nanoparticles (Cur-ZNPs)	1105:1149	The presence of CS improved the antiproliferative activity of curcumin-loaded zein nanoparticles (Cur-ZNPs) to HCT116 cells.
32469014	12	34	theme	hydrophobic	1478:1488	arg1	nutrients					1490:1498	hydrophobic nutrients	1478:1498	hydrophobic nutrients	1478:1498	The studies indicate that the delivery system fabricated in our work would be efficient for improving the application of hydrophobic nutrients in functional foods.
32469014	9	35	theme	nanoparticles	1126:1138	arg1	activity					1093:1100	the antiproliferative activity	1071:1100	the antiproliferative activity of curcumin-loaded zein nanoparticles (Cur-ZNPs) to HCT116 cells	1071:1165	The presence of CS improved the antiproliferative activity of curcumin-loaded zein nanoparticles (Cur-ZNPs) to HCT116 cells.
32469014	7	36	theme	great	899:903	arg1	stability					913:921	great storage stability	899:921	great storage stability at 4 and 22 °C	899:936	Meanwhile, it showed great storage stability at 4 and 22 °C respectively for 30 days.
32469014	1	37	theme	Composite	116:124	arg1	nanoparticles					126:138	Composite nanoparticles	116:138	Composite nanoparticles composed of zein and chondroitin sulfate (CS)	116:184	Composite nanoparticles composed of zein and chondroitin sulfate (CS) were self-assembled by the method of antisolvent precipitation to deliver curcumin (ZCCNPs).
32469014	4	38	theme	curcumin	531:538	arg1	efficiency					517:526	The encapsulation efficiency	499:526	The encapsulation efficiency of curcumin	499:538	The encapsulation efficiency of curcumin was enhanced by CS and showed the maximum (91.97%) when the mass ratio of zein-to-CS was 1 : 1 (ZCCNPs1:1).
32469014	12	39	from	application	1463:1473	arg1	foods					1514:1518	functional foods	1503:1518	functional foods	1503:1518	The studies indicate that the delivery system fabricated in our work would be efficient for improving the application of hydrophobic nutrients in functional foods.
32469014	6	40	theme	excellent	778:786	arg1	thermostability					788:802	excellent thermostability	778:802	excellent thermostability at 35, 55, and 80 °C respectively for 120 min	778:848	ZCCNPs1:1 exhibited great stability at pH 3.0-8.0, and it showed excellent thermostability at 35, 55, and 80 °C respectively for 120 min when the pH was 4.0 or 6.0.
32469014	6	41	from	°C	822:823	arg1	thermostability					788:802	excellent thermostability	778:802	excellent thermostability at 35, 55, and 80 °C respectively for 120 min	778:848	ZCCNPs1:1 exhibited great stability at pH 3.0-8.0, and it showed excellent thermostability at 35, 55, and 80 °C respectively for 120 min when the pH was 4.0 or 6.0.
32469014	7	42	theme	storage	905:911	arg1	stability					913:921	great storage stability	899:921	great storage stability at 4 and 22 °C	899:936	Meanwhile, it showed great storage stability at 4 and 22 °C respectively for 30 days.
32469014	8	43	from	rate	978:981	arg1	ZCCNPs1:1					998:1006	ZCCNPs1:1	998:1006	ZCCNPs1:1	998:1006	The retention rate of curcumin in ZCCNPs1:1 was higher than 65% within 8 days.
32469014	0	44	dep	nanoparticles	25:37	arg1	based					39:43	based	39:43	nanoparticles based on zein as delivery vehicles of curcumin	25:84	Self-assembled composite nanoparticles based on zein as delivery vehicles of curcumin: role of chondroitin sulfate.
32469014	0	44	dep	nanoparticles	25:37	arg1	role					87:90	role	87:90	role of chondroitin sulfate	87:113	Self-assembled composite nanoparticles based on zein as delivery vehicles of curcumin: role of chondroitin sulfate.
32469014	3	45	theme	ZCCNPs	456:461	arg1	resistance					442:451	The resistance	438:451	The resistance of ZCCNPs to degeneration	438:477	The resistance of ZCCNPs to degeneration was improved by CS.
32469014	1	46	theme	antisolvent	223:233	arg1	precipitation					235:247	antisolvent precipitation	223:247	antisolvent precipitation	223:247	Composite nanoparticles composed of zein and chondroitin sulfate (CS) were self-assembled by the method of antisolvent precipitation to deliver curcumin (ZCCNPs).
32469014	7	47	from	°C	935:936	arg1	stability					913:921	great storage stability	899:921	great storage stability at 4 and 22 °C	899:936	Meanwhile, it showed great storage stability at 4 and 22 °C respectively for 30 days.
32469014	1	48	theme	precipitation	235:247	arg1	method					213:218	the method	209:218	the method of antisolvent precipitation	209:247	Composite nanoparticles composed of zein and chondroitin sulfate (CS) were self-assembled by the method of antisolvent precipitation to deliver curcumin (ZCCNPs).
32600259	12	0	theme	gtfB	1802:1805	arg1	genes					1822:1826	gbpB, gtfB, gtfC and gtfD genes	1796:1826	gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans	1796:1895	Xylitol also modified the expression levels of gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans.
32600259	13	1	theme	reduced	2143:2149	arg1	proliferation					2151:2163	reduced proliferation	2143:2163	reduced proliferation	2143:2163	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	4	2	theme	real-time	599:607	arg1	monitoring					609:618	label-free, non-invasive real-time monitoring	574:618	monitoring	609:618	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	5	3	theme	biofilm	947:953	arg1	stages					955:960	different biofilm stages	937:960	different biofilm stages	937:960	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	7	4	theme	real-time	1119:1127	arg1	monitoring					1129:1138	real-time monitoring	1119:1138	real-time monitoring	1119:1138	RESULTS Our results showed that real-time monitoring provided new information of polyol-induced changes in S. mutans biofilm formation dynamics.
32600259	4	5	theme	xylitol	664:670	arg1	effects					653:659	effects	653:659	effects of xylitol on biofilm formation by Streptococcus mutans	653:715	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	6	theme	biofilm	675:681	arg1	formation					683:691	biofilm formation	675:691	biofilm formation by Streptococcus mutans	675:715	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	13	7	theme	biofilm	1960:1966	arg1	formation					1968:1976	biofilm formation	1960:1976	biofilm formation	1960:1976	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	4	8	from	effects	653:659	arg1	formation					683:691	biofilm formation	675:691	biofilm formation by Streptococcus mutans	675:715	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	5	9	theme	selected	873:880	arg1	genes					882:886	selected genes	873:886	selected genes involved in glucan-mediated biofilm formation in different biofilm stages	873:960	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	8	10	theme	inhibitory	1236:1245	arg1	pronounced					1274:1283	pronounced	1274:1283	pronounced	1274:1283	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	8	10	theme	inhibitory	1236:1245	arg1	effect					1247:1252	The inhibitory effect	1232:1252	The inhibitory effect of polyols	1232:1263	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	8	11	from	pronounced	1274:1283	arg1	stages					1298:1303	the early stages	1288:1303	the early stages of biofilm formation	1288:1324	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	9	12	theme	polysaccharide	1492:1505	arg1	amounts					1507:1513	polysaccharide amounts	1492:1513	polysaccharide amounts in the biofilms	1492:1529	Effects seen in the real-time biofilm assay were only partially explained by changes in CFU values and polysaccharide amounts in the biofilms.
32600259	12	13	from	important	1837:1845	arg1	adherence					1874:1882	polysaccharide-mediated adherence	1850:1882	polysaccharide-mediated adherence of S. mutans	1850:1895	Xylitol also modified the expression levels of gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans.
32600259	8	14	theme	biofilm	1308:1314	arg1	formation					1316:1324	biofilm formation	1308:1324	biofilm formation	1308:1324	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	8	15	from	stages	1298:1303	arg1	pronounced					1274:1283	pronounced	1274:1283	pronounced	1274:1283	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	8	15	from	stages	1298:1303	arg1	effect					1247:1252	The inhibitory effect	1232:1252	The inhibitory effect of polyols	1232:1263	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	5	16	theme	different	937:945	arg1	stages					955:960	different biofilm stages	937:960	different biofilm stages	937:960	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	13	17	theme	induced	1938:1944	arg1	inhibition					1946:1955	The erythritol- and xylitol- induced inhibition	1909:1955	The erythritol- and xylitol- induced inhibition of biofilm formation	1909:1976	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	4	18	used	used	475:478	arg2	we					472:473	we	472:473	we	472:473	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	2	19	theme	action	250:255	arg1	mechanism					229:237	the mechanism	225:237	the mechanism of xylitol action	225:255	In vitro biofilm models to study the mechanism of xylitol action have been set-up, but the obtained results are contradictory.
32600259	1	20	theme	streptococci	161:172	arg1	number					140:145	the number	136:145	the number of cariogenic streptococci in dental plaque	136:189	BACKGROUND Regular consumption of xylitol decreases the number of cariogenic streptococci in dental plaque.
32600259	3	21	theme	Biofilm	319:325	arg1	process					347:353	a dynamic process	337:353	a dynamic process with time-specific characteristics that may remain undetected in conventional end-point biofilm tests	337:455	Biofilm growth is a dynamic process with time-specific characteristics that may remain undetected in conventional end-point biofilm tests.
32600259	3	21	theme	Biofilm	319:325	arg1	growth					327:332	Biofilm growth	319:332	Biofilm growth	319:332	Biofilm growth is a dynamic process with time-specific characteristics that may remain undetected in conventional end-point biofilm tests.
32600259	7	22	from	information	1153:1163	arg1	dynamics					1222:1229	S. mutans biofilm formation dynamics	1194:1229	S. mutans biofilm formation dynamics	1194:1229	RESULTS Our results showed that real-time monitoring provided new information of polyol-induced changes in S. mutans biofilm formation dynamics.
32600259	8	23	theme	measured	1348:1355	arg1	amount					1363:1368	the measured total amount	1344:1368	the measured total amount of formed biofilm	1344:1386	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	8	23	theme	measured	1348:1355	arg1	biofilm					1380:1386	formed biofilm	1373:1386	formed biofilm	1373:1386	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	13	24	theme	polysaccharides	2073:2087	arg1	polysaccharides					2073:2087	polysaccharides	2073:2087	polysaccharides in the biofilm matrix	2073:2109	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	24	theme	polysaccharides	2073:2087	arg1	amount					2063:2068	the amount	2059:2068	the amount of polysaccharides in the biofilm matrix	2059:2109	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	24	theme	polysaccharides	2073:2087	arg1	number					2023:2028	the number	2019:2028	the number of viable S. mutans cells	2019:2054	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	24	theme	polysaccharides	2073:2087	arg1	cells					2050:2054	viable S. mutans cells	2033:2054	viable S. mutans cells	2033:2054	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	1	25	theme	dental	177:182	arg1	plaque					184:189	dental plaque	177:189	dental plaque	177:189	BACKGROUND Regular consumption of xylitol decreases the number of cariogenic streptococci in dental plaque.
32600259	4	26	theme	Real	530:533	arg1	RTCA					555:558	RTCA	555:558	RTCA	555:558	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	26	theme	Real	530:533	arg1	Analyzer					545:552	xCELLigence Real Time Cell Analyzer	518:552	xCELLigence Real Time Cell Analyzer (RTCA)	518:559	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	26	theme	Real	530:533	arg1	instrument					506:515	an impedance spectroscopy instrument	480:515	an impedance spectroscopy instrument	480:515	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	13	27	theme	mutans	2043:2048	arg1	cells					2050:2054	viable S. mutans cells	2033:2054	viable S. mutans cells	2033:2054	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	3	28	theme	dynamic	339:345	arg1	process					347:353	a dynamic process	337:353	a dynamic process with time-specific characteristics that may remain undetected in conventional end-point biofilm tests	337:455	Biofilm growth is a dynamic process with time-specific characteristics that may remain undetected in conventional end-point biofilm tests.
32600259	3	28	theme	dynamic	339:345	arg1	growth					327:332	Biofilm growth	319:332	Biofilm growth	319:332	Biofilm growth is a dynamic process with time-specific characteristics that may remain undetected in conventional end-point biofilm tests.
32600259	8	29	theme	formed	1373:1378	arg1	biofilm					1380:1386	formed biofilm	1373:1386	formed biofilm	1373:1386	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	4	30	theme	non-invasive	586:597	arg1	monitoring					609:618	label-free, non-invasive real-time monitoring	574:618	monitoring	609:618	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	12	31	theme	mutans	1890:1895	arg1	adherence					1874:1882	polysaccharide-mediated adherence	1850:1882	polysaccharide-mediated adherence of S. mutans	1850:1895	Xylitol also modified the expression levels of gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans.
32600259	1	32	from	number	140:145	arg1	plaque					184:189	dental plaque	177:189	dental plaque	177:189	BACKGROUND Regular consumption of xylitol decreases the number of cariogenic streptococci in dental plaque.
32600259	1	33	theme	BACKGROUND	84:93	arg1	consumption					103:113	BACKGROUND Regular consumption	84:113	BACKGROUND Regular consumption of xylitol	84:124	BACKGROUND Regular consumption of xylitol decreases the number of cariogenic streptococci in dental plaque.
32600259	4	34	theme	spectroscopy	493:504	arg1	instrument					506:515	an impedance spectroscopy instrument	480:515	an impedance spectroscopy instrument	480:515	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	34	theme	spectroscopy	493:504	arg1	Analyzer					545:552	xCELLigence Real Time Cell Analyzer	518:552	xCELLigence Real Time Cell Analyzer (RTCA)	518:559	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	0	35	theme	mutans	76:81	arg1	formation					49:57	real-time biofilm formation	31:57	real-time biofilm formation of Streptococcus mutans	31:81	Xylitol and erythritol inhibit real-time biofilm formation of Streptococcus mutans.
32600259	3	36	theme	biofilm	443:449	arg1	tests					451:455	conventional end-point biofilm tests	420:455	conventional end-point biofilm tests	420:455	Biofilm growth is a dynamic process with time-specific characteristics that may remain undetected in conventional end-point biofilm tests.
32600259	7	37	theme	mutans	1197:1202	arg1	dynamics					1222:1229	S. mutans biofilm formation dynamics	1194:1229	S. mutans biofilm formation dynamics	1194:1229	RESULTS Our results showed that real-time monitoring provided new information of polyol-induced changes in S. mutans biofilm formation dynamics.
32600259	5	38	theme	polysaccharide	820:833	arg1	content					835:841	the polysaccharide content	816:841	the polysaccharide content	816:841	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	13	39	theme	biofilm	2239:2245	arg1	matrix					2247:2252	biofilm matrix	2239:2252	biofilm matrix	2239:2252	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	12	40	theme	polysaccharide-mediated	1850:1872	arg1	adherence					1874:1882	polysaccharide-mediated adherence	1850:1882	polysaccharide-mediated adherence of S. mutans	1850:1895	Xylitol also modified the expression levels of gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans.
32600259	1	41	theme	xylitol	118:124	arg1	consumption					103:113	BACKGROUND Regular consumption	84:113	BACKGROUND Regular consumption of xylitol	84:124	BACKGROUND Regular consumption of xylitol decreases the number of cariogenic streptococci in dental plaque.
32600259	6	42	theme	positive	1055:1062	arg1	impact					1064:1069	a positive impact	1053:1069	a positive impact	1053:1069	Xylitol inhibition was compared with that of erythritol; another polyol suggested to have a positive impact on oral health.
32600259	3	43	theme	conventional	420:431	arg1	tests					451:455	conventional end-point biofilm tests	420:455	conventional end-point biofilm tests	420:455	Biofilm growth is a dynamic process with time-specific characteristics that may remain undetected in conventional end-point biofilm tests.
32600259	2	44	theme	In	192:193	arg1	models					209:214	In vitro biofilm models	192:214	In vitro biofilm models to study the mechanism of xylitol action	192:255	In vitro biofilm models to study the mechanism of xylitol action have been set-up, but the obtained results are contradictory.
32600259	7	45	theme	polyol-induced	1168:1181	arg1	changes					1183:1189	polyol-induced changes	1168:1189	polyol-induced changes in S. mutans biofilm formation dynamics	1168:1229	RESULTS Our results showed that real-time monitoring provided new information of polyol-induced changes in S. mutans biofilm formation dynamics.
32600259	0	46	theme	real-time	31:39	arg1	formation					49:57	real-time biofilm formation	31:57	real-time biofilm formation of Streptococcus mutans	31:81	Xylitol and erythritol inhibit real-time biofilm formation of Streptococcus mutans.
32600259	4	47	theme	Cell	540:543	arg1	RTCA					555:558	RTCA	555:558	RTCA	555:558	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	47	theme	Cell	540:543	arg1	Analyzer					545:552	xCELLigence Real Time Cell Analyzer	518:552	xCELLigence Real Time Cell Analyzer (RTCA)	518:559	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	47	theme	Cell	540:543	arg1	instrument					506:515	an impedance spectroscopy instrument	480:515	an impedance spectroscopy instrument	480:515	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	0	48	theme	Streptococcus	62:74	arg1	mutans					76:81	Streptococcus mutans	62:81	Streptococcus mutans	62:81	Xylitol and erythritol inhibit real-time biofilm formation of Streptococcus mutans.
32600259	5	49	theme	viable	799:804	arg1	bacteria					806:813	viable bacteria	799:813	viable bacteria	799:813	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	13	50	theme	surface	2209:2215	arg1	quality					2228:2234	thereby the surface attachment quality	2197:2234	thereby the surface attachment quality	2197:2234	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	7	51	theme	formation	1212:1220	arg1	dynamics					1222:1229	S. mutans biofilm formation dynamics	1194:1229	S. mutans biofilm formation dynamics	1194:1229	RESULTS Our results showed that real-time monitoring provided new information of polyol-induced changes in S. mutans biofilm formation dynamics.
32600259	12	52	theme	genes	1822:1826	arg1	levels					1786:1791	the expression levels	1771:1791	the expression levels of gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans	1771:1895	Xylitol also modified the expression levels of gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans.
32600259	9	53	from	changes	1466:1472	arg1	values					1481:1486	CFU values	1477:1486	CFU values	1477:1486	Effects seen in the real-time biofilm assay were only partially explained by changes in CFU values and polysaccharide amounts in the biofilms.
32600259	9	53	from	changes	1466:1472	arg1	biofilms					1522:1529	the biofilms	1518:1529	the biofilms	1518:1529	Effects seen in the real-time biofilm assay were only partially explained by changes in CFU values and polysaccharide amounts in the biofilms.
32600259	10	54	theme	biofilm	1580:1586	arg1	formation					1588:1596	real-time biofilm formation	1570:1596	real-time biofilm formation	1570:1596	Both xylitol and erythritol inhibited real-time biofilm formation by all the nine tested S. mutans strains.
32600259	2	55	theme	biofilm	201:207	arg1	models					209:214	In vitro biofilm models	192:214	In vitro biofilm models to study the mechanism of xylitol action	192:255	In vitro biofilm models to study the mechanism of xylitol action have been set-up, but the obtained results are contradictory.
32600259	9	56	theme	real-time	1409:1417	arg1	assay					1427:1431	the real-time biofilm assay	1405:1431	the real-time biofilm assay	1405:1431	Effects seen in the real-time biofilm assay were only partially explained by changes in CFU values and polysaccharide amounts in the biofilms.
32600259	4	57	theme	biofilm	623:629	arg1	formation					631:639	biofilm formation	623:639	biofilm formation	623:639	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	12	58	theme	expression	1775:1784	arg1	levels					1786:1791	the expression levels	1771:1791	the expression levels of gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans	1771:1895	Xylitol also modified the expression levels of gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans.
32600259	4	59	theme	label-free	574:583	arg1	monitoring					609:618	label-free, non-invasive real-time monitoring	574:618	monitoring	609:618	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	11	60	theme	strains	1659:1665	arg1	Sensitivity					1640:1650	Sensitivity	1640:1650	Sensitivity of the strains to inhibition	1640:1679	Sensitivity of the strains to inhibition varied: some were more sensitive to xylitol and some to erythritol.
32600259	2	61	theme	obtained	283:290	arg1	contradictory					304:316	contradictory	304:316	contradictory	304:316	In vitro biofilm models to study the mechanism of xylitol action have been set-up, but the obtained results are contradictory.
32600259	2	61	theme	obtained	283:290	arg1	results					292:298	the obtained results	279:298	the obtained results	279:298	In vitro biofilm models to study the mechanism of xylitol action have been set-up, but the obtained results are contradictory.
32600259	2	62	dep	In	192:193	arg1	vitro					195:199	vitro	195:199	vitro	195:199	In vitro biofilm models to study the mechanism of xylitol action have been set-up, but the obtained results are contradictory.
32600259	5	63	theme	expression	852:861	arg1	levels					863:868	the expression levels	848:868	the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages	848:960	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	13	64	dep	CONCLUSION	1898:1907	arg1	explained					1994:2002	explained	1994:2002	explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix	1994:2109	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	8	65	theme	polyols	1257:1263	arg1	pronounced					1274:1283	pronounced	1274:1283	pronounced	1274:1283	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	8	65	theme	polyols	1257:1263	arg1	effect					1247:1252	The inhibitory effect	1232:1252	The inhibitory effect of polyols	1232:1263	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	10	66	theme	mutans	1624:1629	arg1	strains					1631:1637	all the nine tested S. mutans strains	1601:1637	all the nine tested S. mutans strains	1601:1637	Both xylitol and erythritol inhibited real-time biofilm formation by all the nine tested S. mutans strains.
32600259	9	67	from	amounts	1507:1513	arg1	values					1481:1486	CFU values	1477:1486	CFU values	1477:1486	Effects seen in the real-time biofilm assay were only partially explained by changes in CFU values and polysaccharide amounts in the biofilms.
32600259	9	67	from	amounts	1507:1513	arg1	biofilms					1522:1529	the biofilms	1518:1529	the biofilms	1518:1529	Effects seen in the real-time biofilm assay were only partially explained by changes in CFU values and polysaccharide amounts in the biofilms.
32600259	10	68	theme	tested	1614:1619	arg1	strains					1631:1637	all the nine tested S. mutans strains	1601:1637	all the nine tested S. mutans strains	1601:1637	Both xylitol and erythritol inhibited real-time biofilm formation by all the nine tested S. mutans strains.
32600259	13	69	theme	formation	1968:1976	arg1	inhibition					1946:1955	The erythritol- and xylitol- induced inhibition	1909:1955	The erythritol- and xylitol- induced inhibition of biofilm formation	1909:1976	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	9	70	theme	CFU	1477:1479	arg1	values					1481:1486	CFU values	1477:1486	CFU values	1477:1486	Effects seen in the real-time biofilm assay were only partially explained by changes in CFU values and polysaccharide amounts in the biofilms.
32600259	12	71	from	adherence	1874:1882	arg1	important					1837:1845	important	1837:1845	important	1837:1845	Xylitol also modified the expression levels of gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans.
32600259	13	72	dep	composition	2181:2191	arg1	the					2170:2172	the	2170:2172	the	2170:2172	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	5	73	theme	glucan-mediated	900:914	arg1	formation					924:932	glucan-mediated biofilm formation	900:932	glucan-mediated biofilm formation in different biofilm stages	900:960	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	1	74	theme	cariogenic	150:159	arg1	streptococci					161:172	cariogenic streptococci	150:172	cariogenic streptococci	150:172	BACKGROUND Regular consumption of xylitol decreases the number of cariogenic streptococci in dental plaque.
32600259	7	75	dep	RESULTS	1087:1093	arg1	showed					1107:1112	showed	1107:1112	showed that real-time monitoring provided new information of polyol-induced changes in S. mutans biofilm formation dynamics	1107:1229	RESULTS Our results showed that real-time monitoring provided new information of polyol-induced changes in S. mutans biofilm formation dynamics.
32600259	2	76	theme	xylitol	242:248	arg1	action					250:255	xylitol action	242:255	xylitol action	242:255	In vitro biofilm models to study the mechanism of xylitol action have been set-up, but the obtained results are contradictory.
32600259	13	77	from	decrease	2007:2014	arg1	polysaccharides					2073:2087	polysaccharides	2073:2087	polysaccharides in the biofilm matrix	2073:2109	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	77	from	decrease	2007:2014	arg1	amount					2063:2068	the amount	2059:2068	the amount of polysaccharides in the biofilm matrix	2059:2109	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	77	from	decrease	2007:2014	arg1	number					2023:2028	the number	2019:2028	the number of viable S. mutans cells	2019:2054	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	77	from	decrease	2007:2014	arg1	cells					2050:2054	viable S. mutans cells	2033:2054	viable S. mutans cells	2033:2054	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	78	from	number	2023:2028	arg1	matrix					2104:2109	the biofilm matrix	2092:2109	the biofilm matrix	2092:2109	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	6	79	theme	Xylitol	963:969	arg1	inhibition					971:980	Xylitol inhibition	963:980	Xylitol inhibition	963:980	Xylitol inhibition was compared with that of erythritol; another polyol suggested to have a positive impact on oral health.
32600259	7	80	from	dynamics	1222:1229	arg1	information					1153:1163	new information	1149:1163	new information of polyol-induced changes in S. mutans biofilm formation dynamics	1149:1229	RESULTS Our results showed that real-time monitoring provided new information of polyol-induced changes in S. mutans biofilm formation dynamics.
32600259	3	81	with	process	347:353	arg1	characteristics					374:388	time-specific characteristics	360:388	time-specific characteristics that may remain undetected in conventional end-point biofilm tests	360:455	Biofilm growth is a dynamic process with time-specific characteristics that may remain undetected in conventional end-point biofilm tests.
32600259	8	82	theme	early	1292:1296	arg1	stages					1298:1303	the early stages	1288:1303	the early stages of biofilm formation	1288:1324	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	13	83	from	amount	2063:2068	arg1	matrix					2104:2109	the biofilm matrix	2092:2109	the biofilm matrix	2092:2109	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	5	84	theme	biofilm	916:922	arg1	formation					924:932	glucan-mediated biofilm formation	900:932	glucan-mediated biofilm formation in different biofilm stages	900:960	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	13	85	theme	erythritol-	1913:1923	arg1	inhibition					1946:1955	The erythritol- and xylitol- induced inhibition	1909:1955	The erythritol- and xylitol- induced inhibition of biofilm formation	1909:1976	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	86	theme	biofilm	2096:2102	arg1	matrix					2104:2109	the biofilm matrix	2092:2109	the biofilm matrix	2092:2109	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	8	87	theme	formation	1316:1324	arg1	stages					1298:1303	the early stages	1288:1303	the early stages of biofilm formation	1288:1324	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	13	88	theme	xylitol-	1929:1936	arg1	inhibition					1946:1955	The erythritol- and xylitol- induced inhibition	1909:1955	The erythritol- and xylitol- induced inhibition of biofilm formation	1909:1976	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	5	89	theme	dynamics	763:770	arg1	information					740:750	the obtained information	727:750	the obtained information of biofilm dynamics	727:770	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	5	90	theme	genes	882:886	arg1	levels					863:868	the expression levels	848:868	the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages	848:960	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	5	90	theme	genes	882:886	arg1	content					835:841	the polysaccharide content	816:841	the polysaccharide content	816:841	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	5	90	theme	genes	882:886	arg1	number					789:794	the number	785:794	the number of viable bacteria	785:813	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	4	91	theme	xCELLigence	518:528	arg1	RTCA					555:558	RTCA	555:558	RTCA	555:558	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	91	theme	xCELLigence	518:528	arg1	Analyzer					545:552	xCELLigence Real Time Cell Analyzer	518:552	xCELLigence Real Time Cell Analyzer (RTCA)	518:559	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	91	theme	xCELLigence	518:528	arg1	instrument					506:515	an impedance spectroscopy instrument	480:515	an impedance spectroscopy instrument	480:515	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	92	theme	impedance	483:491	arg1	instrument					506:515	an impedance spectroscopy instrument	480:515	an impedance spectroscopy instrument	480:515	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	92	theme	impedance	483:491	arg1	Analyzer					545:552	xCELLigence Real Time Cell Analyzer	518:552	xCELLigence Real Time Cell Analyzer (RTCA)	518:559	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	93	theme	Time	535:538	arg1	RTCA					555:558	RTCA	555:558	RTCA	555:558	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	93	theme	Time	535:538	arg1	Analyzer					545:552	xCELLigence Real Time Cell Analyzer	518:552	xCELLigence Real Time Cell Analyzer (RTCA)	518:559	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	93	theme	Time	535:538	arg1	instrument					506:515	an impedance spectroscopy instrument	480:515	an impedance spectroscopy instrument	480:515	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	4	94	theme	Streptococcus	696:708	arg1	mutans					710:715	Streptococcus mutans	696:715	Streptococcus mutans	696:715	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	5	95	theme	obtained	731:738	arg1	information					740:750	the obtained information	727:750	the obtained information of biofilm dynamics	727:770	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	3	96	theme	time-specific	360:372	arg1	characteristics					374:388	time-specific characteristics	360:388	time-specific characteristics that may remain undetected in conventional end-point biofilm tests	360:455	Biofilm growth is a dynamic process with time-specific characteristics that may remain undetected in conventional end-point biofilm tests.
32600259	7	97	from	changes	1183:1189	arg1	dynamics					1222:1229	S. mutans biofilm formation dynamics	1194:1229	S. mutans biofilm formation dynamics	1194:1229	RESULTS Our results showed that real-time monitoring provided new information of polyol-induced changes in S. mutans biofilm formation dynamics.
32600259	8	98	theme	total	1357:1361	arg1	amount					1363:1368	the measured total amount	1344:1368	the measured total amount of formed biofilm	1344:1386	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	8	98	theme	total	1357:1361	arg1	biofilm					1380:1386	formed biofilm	1373:1386	formed biofilm	1373:1386	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	7	99	theme	biofilm	1204:1210	arg1	dynamics					1222:1229	S. mutans biofilm formation dynamics	1194:1229	S. mutans biofilm formation dynamics	1194:1229	RESULTS Our results showed that real-time monitoring provided new information of polyol-induced changes in S. mutans biofilm formation dynamics.
32600259	13	100	theme	cells	2050:2054	arg1	polysaccharides					2073:2087	polysaccharides	2073:2087	polysaccharides in the biofilm matrix	2073:2109	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	100	theme	cells	2050:2054	arg1	amount					2063:2068	the amount	2059:2068	the amount of polysaccharides in the biofilm matrix	2059:2109	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	100	theme	cells	2050:2054	arg1	number					2023:2028	the number	2019:2028	the number of viable S. mutans cells	2019:2054	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	100	theme	cells	2050:2054	arg1	cells					2050:2054	viable S. mutans cells	2033:2054	viable S. mutans cells	2033:2054	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	101	from	polysaccharides	2073:2087	arg1	matrix					2104:2109	the biofilm matrix	2092:2109	the biofilm matrix	2092:2109	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	5	102	theme	bacteria	806:813	arg1	levels					863:868	the expression levels	848:868	the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages	848:960	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	5	102	theme	bacteria	806:813	arg1	content					835:841	the polysaccharide content	816:841	the polysaccharide content	816:841	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	5	102	theme	bacteria	806:813	arg1	number					789:794	the number	785:794	the number of viable bacteria	785:813	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	13	103	from	matrix	2104:2109	arg1	polysaccharides					2073:2087	polysaccharides	2073:2087	polysaccharides in the biofilm matrix	2073:2109	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	103	from	matrix	2104:2109	arg1	amount					2063:2068	the amount	2059:2068	the amount of polysaccharides in the biofilm matrix	2059:2109	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	103	from	matrix	2104:2109	arg1	number					2023:2028	the number	2019:2028	the number of viable S. mutans cells	2019:2054	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	103	from	matrix	2104:2109	arg1	cells					2050:2054	viable S. mutans cells	2033:2054	viable S. mutans cells	2033:2054	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	1	104	theme	Regular	95:101	arg1	consumption					103:113	BACKGROUND Regular consumption	84:113	BACKGROUND Regular consumption of xylitol	84:124	BACKGROUND Regular consumption of xylitol decreases the number of cariogenic streptococci in dental plaque.
32600259	6	105	theme	oral	1074:1077	arg1	health					1079:1084	oral health	1074:1084	oral health	1074:1084	Xylitol inhibition was compared with that of erythritol; another polyol suggested to have a positive impact on oral health.
32600259	8	106	theme	biofilm	1380:1386	arg1	amount					1363:1368	the measured total amount	1344:1368	the measured total amount of formed biofilm	1344:1386	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	8	106	theme	biofilm	1380:1386	arg1	biofilm					1380:1386	formed biofilm	1373:1386	formed biofilm	1373:1386	The inhibitory effect of polyols was more pronounced in the early stages of biofilm formation but affected also the measured total amount of formed biofilm.
32600259	7	107	theme	changes	1183:1189	arg1	information					1153:1163	new information	1149:1163	new information of polyol-induced changes in S. mutans biofilm formation dynamics	1149:1229	RESULTS Our results showed that real-time monitoring provided new information of polyol-induced changes in S. mutans biofilm formation dynamics.
32600259	5	108	from	formation	924:932	arg1	stages					955:960	different biofilm stages	937:960	different biofilm stages	937:960	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	0	109	theme	biofilm	41:47	arg1	formation					49:57	real-time biofilm formation	31:57	real-time biofilm formation of Streptococcus mutans	31:81	Xylitol and erythritol inhibit real-time biofilm formation of Streptococcus mutans.
32600259	13	110	theme	matrix	2247:2252	arg1	composition					2181:2191	matrix composition	2174:2191	matrix composition	2174:2191	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	110	theme	matrix	2247:2252	arg1	quality					2228:2234	thereby the surface attachment quality	2197:2234	thereby the surface attachment quality	2197:2234	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	3	111	theme	end-point	433:441	arg1	tests					451:455	conventional end-point biofilm tests	420:455	conventional end-point biofilm tests	420:455	Biofilm growth is a dynamic process with time-specific characteristics that may remain undetected in conventional end-point biofilm tests.
32600259	5	112	theme	biofilm	755:761	arg1	dynamics					763:770	biofilm dynamics	755:770	biofilm dynamics	755:770	Based on the obtained information of biofilm dynamics, we assessed the number of viable bacteria, the polysaccharide content, and the expression levels of selected genes involved in glucan-mediated biofilm formation in different biofilm stages.
32600259	7	113	theme	new	1149:1151	arg1	information					1153:1163	new information	1149:1163	new information of polyol-induced changes in S. mutans biofilm formation dynamics	1149:1229	RESULTS Our results showed that real-time monitoring provided new information of polyol-induced changes in S. mutans biofilm formation dynamics.
32600259	12	114	theme	gtfC	1808:1811	arg1	genes					1822:1826	gbpB, gtfB, gtfC and gtfD genes	1796:1826	gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans	1796:1895	Xylitol also modified the expression levels of gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans.
32600259	13	115	theme	viable	2033:2038	arg1	cells					2050:2054	viable S. mutans cells	2033:2054	viable S. mutans cells	2033:2054	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	13	116	theme	attachment	2217:2226	arg1	quality					2228:2234	thereby the surface attachment quality	2197:2234	thereby the surface attachment quality	2197:2234	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	12	117	theme	gtfD	1817:1820	arg1	genes					1822:1826	gbpB, gtfB, gtfC and gtfD genes	1796:1826	gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans	1796:1895	Xylitol also modified the expression levels of gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans.
32600259	2	118	dep	models	209:214	arg1	study					219:223	study	219:223	to study the mechanism of xylitol action	216:255	In vitro biofilm models to study the mechanism of xylitol action have been set-up, but the obtained results are contradictory.
32600259	13	119	theme	matrix	2174:2179	arg1	composition					2181:2191	matrix composition	2174:2191	matrix composition	2174:2191	CONCLUSION The erythritol- and xylitol- induced inhibition of biofilm formation was only partly explained by decrease in the number of viable S. mutans cells or the amount of polysaccharides in the biofilm matrix, suggesting that in addition to reduced proliferation also the matrix composition and thereby the surface attachment quality of biofilm matrix may be altered by the polyols.
32600259	12	120	theme	gbpB	1796:1799	arg1	genes					1822:1826	gbpB, gtfB, gtfC and gtfD genes	1796:1826	gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans	1796:1895	Xylitol also modified the expression levels of gbpB, gtfB, gtfC and gtfD genes that are important in polysaccharide-mediated adherence of S. mutans.
32600259	4	121	theme	formation	631:639	arg1	monitoring					609:618	label-free, non-invasive real-time monitoring	574:618	monitoring	609:618	In this study we used an impedance spectroscopy instrument, xCELLigence Real Time Cell Analyzer (RTCA), that allows label-free, non-invasive real-time monitoring of biofilm formation, to explore effects of xylitol on biofilm formation by Streptococcus mutans.
32600259	10	122	theme	real-time	1570:1578	arg1	formation					1588:1596	real-time biofilm formation	1570:1596	real-time biofilm formation	1570:1596	Both xylitol and erythritol inhibited real-time biofilm formation by all the nine tested S. mutans strains.
32600259	7	123	theme	S.	1194:1195	arg1	dynamics					1222:1229	S. mutans biofilm formation dynamics	1194:1229	S. mutans biofilm formation dynamics	1194:1229	RESULTS Our results showed that real-time monitoring provided new information of polyol-induced changes in S. mutans biofilm formation dynamics.
32600259	9	124	theme	biofilm	1419:1425	arg1	assay					1427:1431	the real-time biofilm assay	1405:1431	the real-time biofilm assay	1405:1431	Effects seen in the real-time biofilm assay were only partially explained by changes in CFU values and polysaccharide amounts in the biofilms.
32252045	6	0	theme	articular	1220:1228	arg1	cartilage					1230:1238	native articular cartilage	1213:1238	native articular cartilage	1213:1238	The resulting composites possessed equilibrium and dynamic mechanical properties that matched or approached that of native articular cartilage.
32252045	7	1	theme	FE	1257:1258	arg1	modelling					1261:1269	Finite Element (FE) modelling	1241:1269	Finite Element (FE) modelling	1241:1269	Finite Element (FE) modelling revealed that the reinforcement of IPN hydrogels with specific PCL networks limited radial expansion and increased the hydrostatic pressure generated within the IPN upon the application of compressive loading.
32252045	7	2	theme	Element	1248:1254	arg1	modelling					1261:1269	Finite Element (FE) modelling	1241:1269	Finite Element (FE) modelling	1241:1269	Finite Element (FE) modelling revealed that the reinforcement of IPN hydrogels with specific PCL networks limited radial expansion and increased the hydrostatic pressure generated within the IPN upon the application of compressive loading.
32252045	3	3	theme	interpenetrating	622:637	arg1	hydrogels					653:661	interpenetrating network (IPN) hydrogels	622:661	interpenetrating network (IPN) hydrogels consisting of alginate and gelatin methacryloyl (GelMA)	622:717	Here three-dimensional (3D) bioprinting is used to develop polycaprolactone (PCL) fibre networks to mechanically reinforce interpenetrating network (IPN) hydrogels consisting of alginate and gelatin methacryloyl (GelMA).
32252045	10	4	theme	mechanical	2085:2094	arg1	properties					2096:2105	the mechanical properties	2081:2105	the mechanical properties of articular cartilage	2081:2128	Taken together, these results demonstrate how 3D bioprinting can be used to engineer constructs that are both pro-chondrogenic and biomimetic of the mechanical properties of articular cartilage.
32252045	2	5	theme	engineering	299:309	arg1	strategies					311:320	Such tissue engineering strategies	287:320	Such tissue engineering strategies	287:320	Such tissue engineering strategies require the development of biomaterials that mimic the mechanical properties of articular cartilage whilst simultaneously providing an environment supportive of chondrogenesis.
32252045	4	6	dep	tensile	890:896	arg1	to					898:899	to	898:899	to	898:899	Inspired by the significant tension-compression nonlinearity of the collagen network in articular cartilage, we printed reinforcing PCL networks with different ratios of tensile to compressive modulus.
32252045	4	6	dep	tensile	890:896	arg1	compressive					901:911	compressive	901:911	compressive	901:911	Inspired by the significant tension-compression nonlinearity of the collagen network in articular cartilage, we printed reinforcing PCL networks with different ratios of tensile to compressive modulus.
32252045	4	7	theme	tension-compression	748:766	arg1	nonlinearity					768:779	the significant tension-compression nonlinearity	732:779	the significant tension-compression nonlinearity of the collagen network in articular cartilage	732:826	Inspired by the significant tension-compression nonlinearity of the collagen network in articular cartilage, we printed reinforcing PCL networks with different ratios of tensile to compressive modulus.
32252045	2	8	theme	biomaterials	349:360	arg1	development					334:344	the development	330:344	the development of biomaterials that mimic the mechanical properties of articular cartilage whilst simultaneously providing an environment supportive of chondrogenesis	330:496	Such tissue engineering strategies require the development of biomaterials that mimic the mechanical properties of articular cartilage whilst simultaneously providing an environment supportive of chondrogenesis.
32252045	5	9	theme	IPN	986:988	arg1	hydrogels					990:998	IPN hydrogels	986:998	IPN hydrogels	986:998	Synergistic increases in compressive modulus were observed when IPN hydrogels were reinforced with PCL networks that were relatively soft in compression and stiff in tension.
32252045	10	10	theme	cartilage	2120:2128	arg1	properties					2096:2105	the mechanical properties	2081:2105	the mechanical properties of articular cartilage	2081:2128	Taken together, these results demonstrate how 3D bioprinting can be used to engineer constructs that are both pro-chondrogenic and biomimetic of the mechanical properties of articular cartilage.
32252045	1	11	theme	cartilage	225:233	arg1	biomechanics					195:206	biomechanics	195:206	biomechanics	195:206	Engineering constructs that mimic the complex structure, composition and biomechanics of the articular cartilage represents a promising route to joint regeneration.
32252045	1	11	theme	cartilage	225:233	arg1	composition					179:189	composition	179:189	composition	179:189	Engineering constructs that mimic the complex structure, composition and biomechanics of the articular cartilage represents a promising route to joint regeneration.
32252045	7	12	with	hydrogels	1310:1318	arg1	PCL					1334:1336	specific PCL	1325:1336	specific PCL	1325:1336	Finite Element (FE) modelling revealed that the reinforcement of IPN hydrogels with specific PCL networks limited radial expansion and increased the hydrostatic pressure generated within the IPN upon the application of compressive loading.
32252045	5	13	from	increases	934:942	arg1	modulus					959:965	compressive modulus	947:965	compressive modulus	947:965	Synergistic increases in compressive modulus were observed when IPN hydrogels were reinforced with PCL networks that were relatively soft in compression and stiff in tension.
32252045	8	14	theme	marrow-derived	1613:1626	arg1	BMSCs					1643:1647	BMSCs	1643:1647	BMSCs	1643:1647	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	8	14	theme	marrow-derived	1613:1626	arg1	cells					1636:1640	bone marrow-derived stromal cells	1608:1640	bone marrow-derived stromal cells (BMSCs)	1608:1648	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	2	15	theme	Such	287:290	arg1	strategies					311:320	Such tissue engineering strategies	287:320	Such tissue engineering strategies	287:320	Such tissue engineering strategies require the development of biomaterials that mimic the mechanical properties of articular cartilage whilst simultaneously providing an environment supportive of chondrogenesis.
32252045	9	16	theme	X	1901:1901	arg1	collagen					1903:1910	type X collagen	1896:1910	type X collagen	1896:1910	The bioprinted biomimetic composites were found to support robust chondrogenesis, with encapsulated cells producing hyaline-like cartilage that stained strongly for sGAG and type II collagen deposition, and negatively for type X collagen and calcium deposition.
32252045	8	17	theme	cells	1636:1640	arg1	co-culture					1594:1603	a co-culture	1592:1603	a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs)	1592:1671	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	3	18	theme	gelatin	690:696	arg1	GelMA					712:716	GelMA	712:716	GelMA	712:716	Here three-dimensional (3D) bioprinting is used to develop polycaprolactone (PCL) fibre networks to mechanically reinforce interpenetrating network (IPN) hydrogels consisting of alginate and gelatin methacryloyl (GelMA).
32252045	3	18	theme	gelatin	690:696	arg1	methacryloyl					698:709	gelatin methacryloyl	690:709	gelatin methacryloyl (GelMA)	690:717	Here three-dimensional (3D) bioprinting is used to develop polycaprolactone (PCL) fibre networks to mechanically reinforce interpenetrating network (IPN) hydrogels consisting of alginate and gelatin methacryloyl (GelMA).
32252045	4	19	theme	collagen	788:795	arg1	network					797:803	the collagen network	784:803	the collagen network	784:803	Inspired by the significant tension-compression nonlinearity of the collagen network in articular cartilage, we printed reinforcing PCL networks with different ratios of tensile to compressive modulus.
32252045	7	20	theme	limited	1347:1353	arg1	expansion					1362:1370	limited radial expansion	1347:1370	limited radial expansion	1347:1370	Finite Element (FE) modelling revealed that the reinforcement of IPN hydrogels with specific PCL networks limited radial expansion and increased the hydrostatic pressure generated within the IPN upon the application of compressive loading.
32252045	6	21	theme	resulting	1101:1109	arg1	composites					1111:1120	The resulting composites	1097:1120	The resulting composites	1097:1120	The resulting composites possessed equilibrium and dynamic mechanical properties that matched or approached that of native articular cartilage.
32252045	6	22	contain	possessed	1122:1130	arg2	equilibrium					1132:1142	equilibrium	1132:1142	equilibrium	1132:1142	The resulting composites possessed equilibrium and dynamic mechanical properties that matched or approached that of native articular cartilage.
32252045	6	22	contain	possessed	1122:1130	arg1	composites					1111:1120	The resulting composites	1097:1120	The resulting composites	1097:1120	The resulting composites possessed equilibrium and dynamic mechanical properties that matched or approached that of native articular cartilage.
32252045	6	22	contain	possessed	1122:1130	arg2	properties					1167:1176	dynamic mechanical properties	1148:1176	dynamic mechanical properties	1148:1176	The resulting composites possessed equilibrium and dynamic mechanical properties that matched or approached that of native articular cartilage.
32252045	0	23	theme	mimetic	102:108	arg1	composites					110:119	cartilage mimetic composites	92:119	cartilage mimetic composites	92:119	Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites.
32252045	9	24	theme	bioprinted	1678:1687	arg1	composites					1700:1709	The bioprinted biomimetic composites	1674:1709	The bioprinted biomimetic composites	1674:1709	The bioprinted biomimetic composites were found to support robust chondrogenesis, with encapsulated cells producing hyaline-like cartilage that stained strongly for sGAG and type II collagen deposition, and negatively for type X collagen and calcium deposition.
32252045	4	25	theme	different	870:878	arg1	ratios					880:885	different ratios	870:885	different ratios of tensile to compressive modulus	870:919	Inspired by the significant tension-compression nonlinearity of the collagen network in articular cartilage, we printed reinforcing PCL networks with different ratios of tensile to compressive modulus.
32252045	0	26	theme	Reinforcing	0:10	arg1	network					29:35	Reinforcing interpenetrating network	0:35	Reinforcing interpenetrating network	0:35	Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites.
32252045	7	27	theme	compressive	1460:1470	arg1	loading					1472:1478	compressive loading	1460:1478	compressive loading	1460:1478	Finite Element (FE) modelling revealed that the reinforcement of IPN hydrogels with specific PCL networks limited radial expansion and increased the hydrostatic pressure generated within the IPN upon the application of compressive loading.
32252045	3	28	used	used	542:545	arg2	bioprinting					527:537	three-dimensional (3D) bioprinting	504:537	three-dimensional (3D) bioprinting	504:537	Here three-dimensional (3D) bioprinting is used to develop polycaprolactone (PCL) fibre networks to mechanically reinforce interpenetrating network (IPN) hydrogels consisting of alginate and gelatin methacryloyl (GelMA).
32252045	4	29	theme	modulus	913:919	arg1	ratios					880:885	different ratios	870:885	different ratios of tensile to compressive modulus	870:919	Inspired by the significant tension-compression nonlinearity of the collagen network in articular cartilage, we printed reinforcing PCL networks with different ratios of tensile to compressive modulus.
32252045	8	30	used	used	1532:1535	arg2	techniques					1516:1525	multiple-tool biofabrication techniques	1487:1525	multiple-tool biofabrication techniques	1487:1525	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	5	31	theme	Synergistic	922:932	arg1	increases					934:942	Synergistic increases	922:942	Synergistic increases in compressive modulus	922:965	Synergistic increases in compressive modulus were observed when IPN hydrogels were reinforced with PCL networks that were relatively soft in compression and stiff in tension.
32252045	7	32	theme	IPN	1306:1308	arg1	hydrogels					1310:1318	IPN hydrogels	1306:1318	IPN hydrogels with specific PCL	1306:1336	Finite Element (FE) modelling revealed that the reinforcement of IPN hydrogels with specific PCL networks limited radial expansion and increased the hydrostatic pressure generated within the IPN upon the application of compressive loading.
32252045	8	33	theme	bioprint	1543:1550	arg1	hydrogels					1571:1579	3D bioprint PCL reinforced IPN hydrogels	1540:1579	3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs)	1540:1671	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	3	34	dep	three-dimensional	504:520	arg1	3D					523:524	3D	523:524	3D	523:524	Here three-dimensional (3D) bioprinting is used to develop polycaprolactone (PCL) fibre networks to mechanically reinforce interpenetrating network (IPN) hydrogels consisting of alginate and gelatin methacryloyl (GelMA).
32252045	8	35	link	marrow-derived	1613:1626	arg1	BMSCs					1643:1647	BMSCs	1643:1647	BMSCs	1643:1647	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	8	35	link	marrow-derived	1613:1626	arg1	cells					1636:1640	bone marrow-derived stromal cells	1608:1640	bone marrow-derived stromal cells (BMSCs)	1608:1648	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	8	36	theme	reinforced	1556:1565	arg1	hydrogels					1571:1579	3D bioprint PCL reinforced IPN hydrogels	1540:1579	3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs)	1540:1671	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	0	37	theme	printed	55:61	arg1	networks					71:78	3D printed polymer networks	52:78	3D printed polymer networks	52:78	Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites.
32252045	5	38	from	compression	1063:1073	arg1	soft					1055:1058	soft	1055:1058	soft	1055:1058	Synergistic increases in compressive modulus were observed when IPN hydrogels were reinforced with PCL networks that were relatively soft in compression and stiff in tension.
32252045	1	39	theme	promising	248:256	arg1	route					258:262	a promising route	246:262	a promising route to joint regeneration	246:284	Engineering constructs that mimic the complex structure, composition and biomechanics of the articular cartilage represents a promising route to joint regeneration.
32252045	6	40	theme	mechanical	1156:1165	arg1	properties					1167:1176	dynamic mechanical properties	1148:1176	dynamic mechanical properties	1148:1176	The resulting composites possessed equilibrium and dynamic mechanical properties that matched or approached that of native articular cartilage.
32252045	3	41	theme	fibre	581:585	arg1	networks					587:594	polycaprolactone (PCL) fibre networks	558:594	polycaprolactone (PCL) fibre networks	558:594	Here three-dimensional (3D) bioprinting is used to develop polycaprolactone (PCL) fibre networks to mechanically reinforce interpenetrating network (IPN) hydrogels consisting of alginate and gelatin methacryloyl (GelMA).
32252045	5	42	from	soft	1055:1058	arg1	stiff					1079:1083	stiff	1079:1083	stiff	1079:1083	Synergistic increases in compressive modulus were observed when IPN hydrogels were reinforced with PCL networks that were relatively soft in compression and stiff in tension.
32252045	5	42	from	soft	1055:1058	arg1	compression					1063:1073	compression	1063:1073	compression	1063:1073	Synergistic increases in compressive modulus were observed when IPN hydrogels were reinforced with PCL networks that were relatively soft in compression and stiff in tension.
32252045	5	42	from	soft	1055:1058	arg1	tension					1088:1094	tension	1088:1094	tension	1088:1094	Synergistic increases in compressive modulus were observed when IPN hydrogels were reinforced with PCL networks that were relatively soft in compression and stiff in tension.
32252045	9	43	theme	hyaline-like	1790:1801	arg1	cartilage					1803:1811	hyaline-like cartilage	1790:1811	hyaline-like cartilage that stained strongly for sGAG and type II collagen deposition, and negatively for type X collagen and calcium deposition	1790:1933	The bioprinted biomimetic composites were found to support robust chondrogenesis, with encapsulated cells producing hyaline-like cartilage that stained strongly for sGAG and type II collagen deposition, and negatively for type X collagen and calcium deposition.
32252045	7	44	theme	hydrostatic	1390:1400	arg1	pressure					1402:1409	the hydrostatic pressure	1386:1409	the hydrostatic pressure generated within the IPN	1386:1434	Finite Element (FE) modelling revealed that the reinforcement of IPN hydrogels with specific PCL networks limited radial expansion and increased the hydrostatic pressure generated within the IPN upon the application of compressive loading.
32252045	2	45	theme	articular	402:410	arg1	cartilage					412:420	articular cartilage	402:420	articular cartilage	402:420	Such tissue engineering strategies require the development of biomaterials that mimic the mechanical properties of articular cartilage whilst simultaneously providing an environment supportive of chondrogenesis.
32252045	5	46	from	tension	1088:1094	arg1	soft					1055:1058	soft	1055:1058	soft	1055:1058	Synergistic increases in compressive modulus were observed when IPN hydrogels were reinforced with PCL networks that were relatively soft in compression and stiff in tension.
32252045	6	47	theme	native	1213:1218	arg1	cartilage					1230:1238	native articular cartilage	1213:1238	native articular cartilage	1213:1238	The resulting composites possessed equilibrium and dynamic mechanical properties that matched or approached that of native articular cartilage.
32252045	7	48	theme	Finite	1241:1246	arg1	modelling					1261:1269	Finite Element (FE) modelling	1241:1269	Finite Element (FE) modelling	1241:1269	Finite Element (FE) modelling revealed that the reinforcement of IPN hydrogels with specific PCL networks limited radial expansion and increased the hydrostatic pressure generated within the IPN upon the application of compressive loading.
32252045	4	49	from	nonlinearity	768:779	arg1	cartilage					818:826	articular cartilage	808:826	articular cartilage	808:826	Inspired by the significant tension-compression nonlinearity of the collagen network in articular cartilage, we printed reinforcing PCL networks with different ratios of tensile to compressive modulus.
32252045	10	50	theme	properties	2096:2105	arg1	pro-chondrogenic					2046:2061	pro-chondrogenic	2046:2061	pro-chondrogenic	2046:2061	Taken together, these results demonstrate how 3D bioprinting can be used to engineer constructs that are both pro-chondrogenic and biomimetic of the mechanical properties of articular cartilage.
32252045	3	51	theme	IPN	648:650	arg1	hydrogels					653:661	interpenetrating network (IPN) hydrogels	622:661	interpenetrating network (IPN) hydrogels consisting of alginate and gelatin methacryloyl (GelMA)	622:717	Here three-dimensional (3D) bioprinting is used to develop polycaprolactone (PCL) fibre networks to mechanically reinforce interpenetrating network (IPN) hydrogels consisting of alginate and gelatin methacryloyl (GelMA).
32252045	9	52	theme	type	1848:1851	arg1	collagen					1856:1863	type II collagen	1848:1863	type II collagen deposition	1848:1874	The bioprinted biomimetic composites were found to support robust chondrogenesis, with encapsulated cells producing hyaline-like cartilage that stained strongly for sGAG and type II collagen deposition, and negatively for type X collagen and calcium deposition.
32252045	4	53	theme	significant	736:746	arg1	nonlinearity					768:779	the significant tension-compression nonlinearity	732:779	the significant tension-compression nonlinearity of the collagen network in articular cartilage	732:826	Inspired by the significant tension-compression nonlinearity of the collagen network in articular cartilage, we printed reinforcing PCL networks with different ratios of tensile to compressive modulus.
32252045	3	54	theme	network	639:645	arg1	hydrogels					653:661	interpenetrating network (IPN) hydrogels	622:661	interpenetrating network (IPN) hydrogels consisting of alginate and gelatin methacryloyl (GelMA)	622:717	Here three-dimensional (3D) bioprinting is used to develop polycaprolactone (PCL) fibre networks to mechanically reinforce interpenetrating network (IPN) hydrogels consisting of alginate and gelatin methacryloyl (GelMA).
32252045	1	55	theme	articular	215:223	arg1	cartilage					225:233	the articular cartilage	211:233	the articular cartilage	211:233	Engineering constructs that mimic the complex structure, composition and biomechanics of the articular cartilage represents a promising route to joint regeneration.
32252045	9	56	theme	collagen	1856:1863	arg1	deposition					1865:1874	type II collagen deposition	1848:1874	type II collagen deposition	1848:1874	The bioprinted biomimetic composites were found to support robust chondrogenesis, with encapsulated cells producing hyaline-like cartilage that stained strongly for sGAG and type II collagen deposition, and negatively for type X collagen and calcium deposition.
32252045	10	57	theme	articular	2110:2118	arg1	cartilage					2120:2128	articular cartilage	2110:2128	articular cartilage	2110:2128	Taken together, these results demonstrate how 3D bioprinting can be used to engineer constructs that are both pro-chondrogenic and biomimetic of the mechanical properties of articular cartilage.
32252045	5	58	theme	compressive	947:957	arg1	modulus					959:965	compressive modulus	947:965	compressive modulus	947:965	Synergistic increases in compressive modulus were observed when IPN hydrogels were reinforced with PCL networks that were relatively soft in compression and stiff in tension.
32252045	8	59	theme	bone	1608:1611	arg1	BMSCs					1643:1647	BMSCs	1643:1647	BMSCs	1643:1647	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	8	59	theme	bone	1608:1611	arg1	cells					1636:1640	bone marrow-derived stromal cells	1608:1640	bone marrow-derived stromal cells (BMSCs)	1608:1648	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	5	60	theme	PCL	1021:1023	arg1	networks					1025:1032	PCL networks	1021:1032	PCL networks that were relatively soft in compression and stiff in tension	1021:1094	Synergistic increases in compressive modulus were observed when IPN hydrogels were reinforced with PCL networks that were relatively soft in compression and stiff in tension.
32252045	8	61	theme	stromal	1628:1634	arg1	BMSCs					1643:1647	BMSCs	1643:1647	BMSCs	1643:1647	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	8	61	theme	stromal	1628:1634	arg1	cells					1636:1640	bone marrow-derived stromal cells	1608:1640	bone marrow-derived stromal cells (BMSCs)	1608:1648	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	4	62	theme	network	797:803	arg1	nonlinearity					768:779	the significant tension-compression nonlinearity	732:779	the significant tension-compression nonlinearity of the collagen network in articular cartilage	732:826	Inspired by the significant tension-compression nonlinearity of the collagen network in articular cartilage, we printed reinforcing PCL networks with different ratios of tensile to compressive modulus.
32252045	2	63	theme	tissue	292:297	arg1	strategies					311:320	Such tissue engineering strategies	287:320	Such tissue engineering strategies	287:320	Such tissue engineering strategies require the development of biomaterials that mimic the mechanical properties of articular cartilage whilst simultaneously providing an environment supportive of chondrogenesis.
32252045	6	64	theme	dynamic	1148:1154	arg1	properties					1167:1176	dynamic mechanical properties	1148:1176	dynamic mechanical properties	1148:1176	The resulting composites possessed equilibrium and dynamic mechanical properties that matched or approached that of native articular cartilage.
32252045	9	65	theme	type	1896:1899	arg1	collagen					1903:1910	type X collagen	1896:1910	type X collagen	1896:1910	The bioprinted biomimetic composites were found to support robust chondrogenesis, with encapsulated cells producing hyaline-like cartilage that stained strongly for sGAG and type II collagen deposition, and negatively for type X collagen and calcium deposition.
32252045	4	66	theme	articular	808:816	arg1	cartilage					818:826	articular cartilage	808:826	articular cartilage	808:826	Inspired by the significant tension-compression nonlinearity of the collagen network in articular cartilage, we printed reinforcing PCL networks with different ratios of tensile to compressive modulus.
32252045	7	67	theme	radial	1355:1360	arg1	expansion					1362:1370	limited radial expansion	1347:1370	limited radial expansion	1347:1370	Finite Element (FE) modelling revealed that the reinforcement of IPN hydrogels with specific PCL networks limited radial expansion and increased the hydrostatic pressure generated within the IPN upon the application of compressive loading.
32252045	10	68	theme	3D	1982:1983	arg1	bioprinting					1985:1995	3D bioprinting	1982:1995	3D bioprinting	1982:1995	Taken together, these results demonstrate how 3D bioprinting can be used to engineer constructs that are both pro-chondrogenic and biomimetic of the mechanical properties of articular cartilage.
32252045	1	69	theme	complex	160:166	arg1	structure					168:176	the complex structure	156:176	the complex structure	156:176	Engineering constructs that mimic the complex structure, composition and biomechanics of the articular cartilage represents a promising route to joint regeneration.
32252045	0	70	theme	cartilage	92:100	arg1	composites					110:119	cartilage mimetic composites	92:119	cartilage mimetic composites	92:119	Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites.
32252045	9	71	theme	calcium	1916:1922	arg1	deposition					1924:1933	calcium deposition	1916:1933	calcium deposition	1916:1933	The bioprinted biomimetic composites were found to support robust chondrogenesis, with encapsulated cells producing hyaline-like cartilage that stained strongly for sGAG and type II collagen deposition, and negatively for type X collagen and calcium deposition.
32252045	8	72	theme	chondrocytes	1654:1665	arg1	co-culture					1594:1603	a co-culture	1592:1603	a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs)	1592:1671	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	7	73	theme	specific	1325:1332	arg1	PCL					1334:1336	specific PCL	1325:1336	specific PCL	1325:1336	Finite Element (FE) modelling revealed that the reinforcement of IPN hydrogels with specific PCL networks limited radial expansion and increased the hydrostatic pressure generated within the IPN upon the application of compressive loading.
32252045	4	74	theme	PCL	852:854	arg1	networks					856:863	PCL networks	852:863	PCL networks	852:863	Inspired by the significant tension-compression nonlinearity of the collagen network in articular cartilage, we printed reinforcing PCL networks with different ratios of tensile to compressive modulus.
32252045	7	75	theme	hydrogels	1310:1318	arg1	reinforcement					1289:1301	the reinforcement	1285:1301	the reinforcement of IPN hydrogels with specific PCL	1285:1336	Finite Element (FE) modelling revealed that the reinforcement of IPN hydrogels with specific PCL networks limited radial expansion and increased the hydrostatic pressure generated within the IPN upon the application of compressive loading.
32252045	9	76	theme	biomimetic	1689:1698	arg1	composites					1700:1709	The bioprinted biomimetic composites	1674:1709	The bioprinted biomimetic composites	1674:1709	The bioprinted biomimetic composites were found to support robust chondrogenesis, with encapsulated cells producing hyaline-like cartilage that stained strongly for sGAG and type II collagen deposition, and negatively for type X collagen and calcium deposition.
32252045	7	77	theme	loading	1472:1478	arg1	application					1445:1455	the application	1441:1455	the application of compressive loading	1441:1478	Finite Element (FE) modelling revealed that the reinforcement of IPN hydrogels with specific PCL networks limited radial expansion and increased the hydrostatic pressure generated within the IPN upon the application of compressive loading.
32252045	8	78	theme	multiple-tool	1487:1499	arg1	techniques					1516:1525	multiple-tool biofabrication techniques	1487:1525	multiple-tool biofabrication techniques	1487:1525	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	0	79	theme	interpenetrating	12:27	arg1	network					29:35	Reinforcing interpenetrating network	0:35	Reinforcing interpenetrating network	0:35	Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites.
32252045	3	80	theme	three-dimensional	504:520	arg1	bioprinting					527:537	three-dimensional (3D) bioprinting	504:537	three-dimensional (3D) bioprinting	504:537	Here three-dimensional (3D) bioprinting is used to develop polycaprolactone (PCL) fibre networks to mechanically reinforce interpenetrating network (IPN) hydrogels consisting of alginate and gelatin methacryloyl (GelMA).
32252045	8	81	theme	biofabrication	1501:1514	arg1	techniques					1516:1525	multiple-tool biofabrication techniques	1487:1525	multiple-tool biofabrication techniques	1487:1525	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	2	82	theme	chondrogenesis	483:496	arg1	environment					457:467	an environment supportive	454:478	an environment supportive of chondrogenesis	454:496	Such tissue engineering strategies require the development of biomaterials that mimic the mechanical properties of articular cartilage whilst simultaneously providing an environment supportive of chondrogenesis.
32252045	0	83	theme	3D	52:53	arg1	networks					71:78	3D printed polymer networks	52:78	3D printed polymer networks	52:78	Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites.
32252045	5	84	from	stiff	1079:1083	arg1	soft					1055:1058	soft	1055:1058	soft	1055:1058	Synergistic increases in compressive modulus were observed when IPN hydrogels were reinforced with PCL networks that were relatively soft in compression and stiff in tension.
32252045	9	85	theme	robust	1733:1738	arg1	chondrogenesis					1740:1753	robust chondrogenesis	1733:1753	robust chondrogenesis	1733:1753	The bioprinted biomimetic composites were found to support robust chondrogenesis, with encapsulated cells producing hyaline-like cartilage that stained strongly for sGAG and type II collagen deposition, and negatively for type X collagen and calcium deposition.
32252045	8	86	theme	3D	1540:1541	arg1	hydrogels					1571:1579	3D bioprint PCL reinforced IPN hydrogels	1540:1579	3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs)	1540:1671	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	2	87	theme	supportive	469:478	arg1	environment					457:467	an environment supportive	454:478	an environment supportive of chondrogenesis	454:496	Such tissue engineering strategies require the development of biomaterials that mimic the mechanical properties of articular cartilage whilst simultaneously providing an environment supportive of chondrogenesis.
32252045	0	88	theme	polymer	63:69	arg1	networks					71:78	3D printed polymer networks	52:78	3D printed polymer networks	52:78	Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites.
32252045	10	89	used	used	2004:2007	arg2	bioprinting					1985:1995	3D bioprinting	1982:1995	3D bioprinting	1982:1995	Taken together, these results demonstrate how 3D bioprinting can be used to engineer constructs that are both pro-chondrogenic and biomimetic of the mechanical properties of articular cartilage.
32252045	8	90	theme	PCL	1552:1554	arg1	hydrogels					1571:1579	3D bioprint PCL reinforced IPN hydrogels	1540:1579	3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs)	1540:1671	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	2	91	theme	mechanical	377:386	arg1	properties					388:397	the mechanical properties	373:397	the mechanical properties of articular cartilage	373:420	Such tissue engineering strategies require the development of biomaterials that mimic the mechanical properties of articular cartilage whilst simultaneously providing an environment supportive of chondrogenesis.
32252045	9	92	theme	encapsulated	1761:1772	arg1	cells					1774:1778	encapsulated cells	1761:1778	encapsulated cells producing hyaline-like cartilage that stained strongly for sGAG and type II collagen deposition, and negatively for type X collagen and calcium deposition	1761:1933	The bioprinted biomimetic composites were found to support robust chondrogenesis, with encapsulated cells producing hyaline-like cartilage that stained strongly for sGAG and type II collagen deposition, and negatively for type X collagen and calcium deposition.
32252045	8	93	theme	IPN	1567:1569	arg1	hydrogels					1571:1579	3D bioprint PCL reinforced IPN hydrogels	1540:1579	3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs)	1540:1671	Next, multiple-tool biofabrication techniques were used to 3D bioprint PCL reinforced IPN hydrogels laden with a co-culture of bone marrow-derived stromal cells (BMSCs) and chondrocytes (CCs).
32252045	4	94	theme	tensile	890:896	arg1	modulus					913:919	tensile to compressive modulus	890:919	tensile to compressive modulus	890:919	Inspired by the significant tension-compression nonlinearity of the collagen network in articular cartilage, we printed reinforcing PCL networks with different ratios of tensile to compressive modulus.
32252045	2	95	theme	cartilage	412:420	arg1	properties					388:397	the mechanical properties	373:397	the mechanical properties of articular cartilage	373:420	Such tissue engineering strategies require the development of biomaterials that mimic the mechanical properties of articular cartilage whilst simultaneously providing an environment supportive of chondrogenesis.
32252045	1	96	theme	joint	267:271	arg1	regeneration					273:284	joint regeneration	267:284	joint regeneration	267:284	Engineering constructs that mimic the complex structure, composition and biomechanics of the articular cartilage represents a promising route to joint regeneration.
34607010	9	0	dep	increased	1252:1260	arg1	compared					1262:1269	compared	1262:1269	compared to those in the control group	1262:1299	In both the kidney and spleen, the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group were significantly increased compared to those in the control group.
34607010	7	1	theme	parameters	870:879	arg1	regulation					837:846	positive regulation	828:846	positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity	828:958	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	4	2	theme	rockfish	396:403	arg1	intestine					383:391	the intestine	379:391	the intestine of rockfish (Sebastes schlegelii)	379:425	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii) was demonstrated to be safe based on in vitro tests confirming the absence of hemolysis, cytotoxicity, and genes with toxigenic potential.
34607010	9	3	theme	IL-10	1157:1161	arg1	levels					1147:1152	the expression levels	1132:1152	the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group	1132:1231	In both the kidney and spleen, the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group were significantly increased compared to those in the control group.
34607010	6	4	theme	juvenile	780:787	arg1	rockfish					789:796	juvenile rockfish	780:796	juvenile rockfish	780:796	KRF-7 was observed to positively alter the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish.
34607010	7	5	theme	nonspecific	851:861	arg1	dismutase					901:909	superoxide dismutase	890:909	superoxide dismutase	890:909	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	7	5	theme	nonspecific	851:861	arg1	parameters					870:879	nonspecific immune parameters	851:879	nonspecific immune parameters	851:879	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	7	5	theme	nonspecific	851:861	arg1	activity					921:928	lysozyme activity	912:928	lysozyme activity	912:928	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	7	5	theme	nonspecific	851:861	arg1	activity					951:958	myeloperoxidase activity	935:958	myeloperoxidase activity	935:958	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	10	6	theme	intestinal	1542:1551	arg1	microbiota					1553:1562	the intestinal microbiota	1538:1562	the intestinal microbiota	1538:1562	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	9	7	theme	B	1175:1175	arg1	factors					1193:1199	B cell activating factors	1175:1199	B cell activating factors	1175:1199	In both the kidney and spleen, the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group were significantly increased compared to those in the control group.
34607010	4	8	with	genes	534:538	arg1	potential					555:563	toxigenic potential	545:563	toxigenic potential	545:563	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii) was demonstrated to be safe based on in vitro tests confirming the absence of hemolysis, cytotoxicity, and genes with toxigenic potential.
34607010	5	9	theme	1 × 108 CFU g-1Bacillus	619:641	arg1	sp					643:644	1 × 108 CFU g-1Bacillus sp	619:644	1 × 108 CFU g-1Bacillus sp	619:644	In a feeding trial, providing a supplemental diet of 1 × 108 CFU g-1Bacillus sp.
34607010	6	10	theme	protein	752:758	arg1	efficiency					760:769	protein efficiency	752:769	protein efficiency	752:769	KRF-7 was observed to positively alter the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish.
34607010	2	11	theme	supplementation	305:319	arg1	effects					289:295	the effects	285:295	the effects of feed supplementation in rockfish aquaculture	285:343	The purpose of this study was to characterize the bacteria isolated from rockfish intestines and to investigate the effects of feed supplementation in rockfish aquaculture.
34607010	10	12	theme	response	1575:1582	arg1	regulation					1524:1533	the regulation	1520:1533	the regulation of the intestinal microbiota and immune response	1520:1582	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	7	13	theme	KRF-7	799:803	arg1	supplementation					805:819	KRF-7 supplementation	799:819	KRF-7 supplementation	799:819	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	9	14	theme	KRF-7-supplemented	1208:1225	arg1	group					1227:1231	the KRF-7-supplemented group	1204:1231	the KRF-7-supplemented group	1204:1231	In both the kidney and spleen, the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group were significantly increased compared to those in the control group.
34607010	10	15	theme	rockfish	1384:1391	arg1	intestine					1371:1379	the intestine	1367:1379	the intestine of rockfish	1367:1391	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	1	16	theme	supplementation	104:118	arg1	effects					85:91	effects	85:91	effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture	85:170	KRF-7 isolated from the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture.
34607010	1	16	theme	supplementation	104:118	arg1	rockfish					72:79	rockfish	72:79	rockfish	72:79	KRF-7 isolated from the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture.
34607010	6	17	theme	rockfish	789:796	arg1	ratio					771:775	the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio	686:775	the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish	686:796	KRF-7 was observed to positively alter the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish.
34607010	1	18	theme	mannan	125:130	arg1	oligosaccharide					132:146	mannan oligosaccharide	125:146	mannan oligosaccharide	125:146	KRF-7 isolated from the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture.
34607010	2	19	from	effects	289:295	arg1	aquaculture					333:343	rockfish aquaculture	324:343	rockfish aquaculture	324:343	The purpose of this study was to characterize the bacteria isolated from rockfish intestines and to investigate the effects of feed supplementation in rockfish aquaculture.
34607010	8	20	from	Proteobacteria	1071:1084	arg1	level					1060:1064	the phylum level	1049:1064	the phylum level from Proteobacteria to Firmicutes	1049:1098	This analysis also revealed a change in the composition of the intestinal microbiota at the phylum level from Proteobacteria to Firmicutes.
34607010	4	21	dep	Sebastes	406:413	arg1	schlegelii					415:424	Sebastes schlegelii	406:424	Sebastes schlegelii	406:424	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii) was demonstrated to be safe based on in vitro tests confirming the absence of hemolysis, cytotoxicity, and genes with toxigenic potential.
34607010	2	22	attach	isolated	232:239	arg1	intestines					255:264	rockfish intestines	246:264	rockfish intestines	246:264	The purpose of this study was to characterize the bacteria isolated from rockfish intestines and to investigate the effects of feed supplementation in rockfish aquaculture.
34607010	2	22	attach	isolated	232:239	arg2	bacteria					223:230	the bacteria	219:230	the bacteria isolated from rockfish intestines	219:264	The purpose of this study was to characterize the bacteria isolated from rockfish intestines and to investigate the effects of feed supplementation in rockfish aquaculture.
34607010	10	23	theme	dietary	1411:1417	arg1	supplementation					1419:1433	dietary supplementation	1411:1433	dietary supplementation with KRF-7	1411:1444	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	10	24	attach	isolated	1353:1360	arg2	KRF-7					1347:1351	KRF-7	1347:1351	KRF-7 isolated from the intestine of rockfish	1347:1391	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	10	24	attach	isolated	1353:1360	arg1	intestine					1371:1379	the intestine	1367:1379	the intestine of rockfish	1367:1391	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	9	25	theme	control	1287:1293	arg1	group					1295:1299	the control group	1283:1299	the control group	1283:1299	In both the kidney and spleen, the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group were significantly increased compared to those in the control group.
34607010	8	26	theme	microbiota	1035:1044	arg1	composition					1005:1015	the composition	1001:1015	the composition of the intestinal microbiota	1001:1044	This analysis also revealed a change in the composition of the intestinal microbiota at the phylum level from Proteobacteria to Firmicutes.
34607010	10	27	from	effects	1509:1515	arg1	regulation					1524:1533	the regulation	1520:1533	the regulation of the intestinal microbiota and immune response	1520:1582	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	4	28	theme	in	464:465	arg1	tests					473:477	in vitro tests	464:477	in vitro tests	464:477	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii) was demonstrated to be safe based on in vitro tests confirming the absence of hemolysis, cytotoxicity, and genes with toxigenic potential.
34607010	10	29	theme	growth	1459:1464	arg1	performance					1466:1476	the growth performance	1455:1476	the growth performance of rockfish	1455:1488	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	6	30	theme	gain	697:700	arg1	ratio					771:775	the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio	686:775	the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish	686:796	KRF-7 was observed to positively alter the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish.
34607010	1	31	with	supplementation	104:118	arg1	oligosaccharide					132:146	mannan oligosaccharide	125:146	mannan oligosaccharide	125:146	KRF-7 isolated from the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture.
34607010	4	32	theme	genes	534:538	arg1	absence					494:500	the absence	490:500	the absence of hemolysis, cytotoxicity, and genes with toxigenic potential	490:563	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii) was demonstrated to be safe based on in vitro tests confirming the absence of hemolysis, cytotoxicity, and genes with toxigenic potential.
34607010	4	33	theme	toxigenic	545:553	arg1	potential					555:563	toxigenic potential	545:563	toxigenic potential	545:563	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii) was demonstrated to be safe based on in vitro tests confirming the absence of hemolysis, cytotoxicity, and genes with toxigenic potential.
34607010	0	34	theme	sp	31:32	arg1	Characterization					0:15	Characterization	0:15	Characterization of a Bacillus sp.	0:33	Characterization of a Bacillus sp.
34607010	6	35	theme	ratio	741:745	arg1	ratio					771:775	the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio	686:775	the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish	686:796	KRF-7 was observed to positively alter the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish.
34607010	4	36	with	hemolysis	505:513	arg1	potential					555:563	toxigenic potential	545:563	toxigenic potential	545:563	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii) was demonstrated to be safe based on in vitro tests confirming the absence of hemolysis, cytotoxicity, and genes with toxigenic potential.
34607010	10	37	theme	beneficial	1498:1507	arg1	effects					1509:1515	beneficial effects	1498:1515	beneficial effects on the regulation of the intestinal microbiota and immune response	1498:1582	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	6	38	theme	feed	725:728	arg1	ratio					741:745	feed conversion ratio	725:745	feed conversion ratio	725:745	KRF-7 was observed to positively alter the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish.
34607010	7	39	theme	lysozyme	912:919	arg1	activity					921:928	lysozyme activity	912:928	lysozyme activity	912:928	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	6	40	theme	rate	719:722	arg1	ratio					771:775	the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio	686:775	the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish	686:796	KRF-7 was observed to positively alter the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish.
34607010	5	41	theme	sp	643:644	arg1	diet					611:614	a supplemental diet	596:614	a supplemental diet of 1 × 108 CFU g-1Bacillus sp	596:644	In a feeding trial, providing a supplemental diet of 1 × 108 CFU g-1Bacillus sp.
34607010	6	42	theme	specific	703:710	arg1	rate					719:722	specific growth rate	703:722	specific growth rate	703:722	KRF-7 was observed to positively alter the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish.
34607010	10	43	theme	immune	1568:1573	arg1	response					1575:1582	immune response	1568:1582	immune response	1568:1582	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	6	44	theme	efficiency	760:769	arg1	ratio					771:775	the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio	686:775	the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish	686:796	KRF-7 was observed to positively alter the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish.
34607010	9	45	theme	NF-κB	1164:1168	arg1	levels					1147:1152	the expression levels	1132:1152	the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group	1132:1231	In both the kidney and spleen, the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group were significantly increased compared to those in the control group.
34607010	10	46	theme	microbiota	1553:1562	arg1	regulation					1524:1533	the regulation	1520:1533	the regulation of the intestinal microbiota and immune response	1520:1582	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	5	47	theme	supplemental	598:609	arg1	diet					611:614	a supplemental diet	596:614	a supplemental diet of 1 × 108 CFU g-1Bacillus sp	596:644	In a feeding trial, providing a supplemental diet of 1 × 108 CFU g-1Bacillus sp.
34607010	7	48	theme	immune	863:868	arg1	dismutase					901:909	superoxide dismutase	890:909	superoxide dismutase	890:909	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	7	48	theme	immune	863:868	arg1	parameters					870:879	nonspecific immune parameters	851:879	nonspecific immune parameters	851:879	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	7	48	theme	immune	863:868	arg1	activity					921:928	lysozyme activity	912:928	lysozyme activity	912:928	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	7	48	theme	immune	863:868	arg1	activity					951:958	myeloperoxidase activity	935:958	myeloperoxidase activity	935:958	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	9	49	theme	cell	1177:1180	arg1	factors					1193:1199	B cell activating factors	1175:1199	B cell activating factors	1175:1199	In both the kidney and spleen, the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group were significantly increased compared to those in the control group.
34607010	9	50	from	levels	1147:1152	arg1	group					1227:1231	the KRF-7-supplemented group	1204:1231	the KRF-7-supplemented group	1204:1231	In both the kidney and spleen, the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group were significantly increased compared to those in the control group.
34607010	9	51	theme	activating	1182:1191	arg1	factors					1193:1199	B cell activating factors	1175:1199	B cell activating factors	1175:1199	In both the kidney and spleen, the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group were significantly increased compared to those in the control group.
34607010	9	52	theme	factors	1193:1199	arg1	levels					1147:1152	the expression levels	1132:1152	the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group	1132:1231	In both the kidney and spleen, the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group were significantly increased compared to those in the control group.
34607010	4	53	with	cytotoxicity	516:527	arg1	potential					555:563	toxigenic potential	545:563	toxigenic potential	545:563	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii) was demonstrated to be safe based on in vitro tests confirming the absence of hemolysis, cytotoxicity, and genes with toxigenic potential.
34607010	7	54	theme	positive	828:835	arg1	regulation					837:846	positive regulation	828:846	positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity	828:958	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	1	55	theme	dietary	96:102	arg1	supplementation					104:118	dietary supplementation	96:118	dietary supplementation with mannan oligosaccharide	96:146	KRF-7 isolated from the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture.
34607010	2	56	theme	feed	300:303	arg1	supplementation					305:319	feed supplementation	300:319	feed supplementation	300:319	The purpose of this study was to characterize the bacteria isolated from rockfish intestines and to investigate the effects of feed supplementation in rockfish aquaculture.
34607010	2	57	theme	rockfish	246:253	arg1	intestines					255:264	rockfish intestines	246:264	rockfish intestines	246:264	The purpose of this study was to characterize the bacteria isolated from rockfish intestines and to investigate the effects of feed supplementation in rockfish aquaculture.
34607010	10	58	contain	has	1494:1496	arg1	supplementation					1419:1433	dietary supplementation	1411:1433	dietary supplementation with KRF-7	1411:1444	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	10	58	contain	has	1494:1496	arg2	effects					1509:1515	beneficial effects	1498:1515	beneficial effects on the regulation of the intestinal microbiota and immune response	1498:1582	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	3	59	theme	Bacillus	346:353	arg1	sp					355:356	Bacillus sp	346:356	Bacillus sp.	346:357	Bacillus sp.
34607010	8	60	theme	intestinal	1024:1033	arg1	microbiota					1035:1044	the intestinal microbiota	1020:1044	the intestinal microbiota	1020:1044	This analysis also revealed a change in the composition of the intestinal microbiota at the phylum level from Proteobacteria to Firmicutes.
34607010	1	61	theme	rockfish	151:158	arg1	aquaculture					160:170	rockfish aquaculture	151:170	rockfish aquaculture	151:170	KRF-7 isolated from the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture.
34607010	4	62	attach	isolated	365:372	arg1	intestine					383:391	the intestine	379:391	the intestine of rockfish (Sebastes schlegelii)	379:425	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii) was demonstrated to be safe based on in vitro tests confirming the absence of hemolysis, cytotoxicity, and genes with toxigenic potential.
34607010	4	62	attach	isolated	365:372	arg2	KRF-7					359:363	KRF-7	359:363	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii)	359:425	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii) was demonstrated to be safe based on in vitro tests confirming the absence of hemolysis, cytotoxicity, and genes with toxigenic potential.
34607010	4	63	theme	hemolysis	505:513	arg1	absence					494:500	the absence	490:500	the absence of hemolysis, cytotoxicity, and genes with toxigenic potential	490:563	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii) was demonstrated to be safe based on in vitro tests confirming the absence of hemolysis, cytotoxicity, and genes with toxigenic potential.
34607010	1	64	from	aquaculture	160:170	arg1	intestine					59:67	the intestine	55:67	the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture	55:170	KRF-7 isolated from the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture.
34607010	9	65	theme	expression	1136:1145	arg1	levels					1147:1152	the expression levels	1132:1152	the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group	1132:1231	In both the kidney and spleen, the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group were significantly increased compared to those in the control group.
34607010	8	66	theme	phylum	1053:1058	arg1	level					1060:1064	the phylum level	1049:1064	the phylum level from Proteobacteria to Firmicutes	1049:1098	This analysis also revealed a change in the composition of the intestinal microbiota at the phylum level from Proteobacteria to Firmicutes.
34607010	7	67	theme	superoxide	890:899	arg1	dismutase					901:909	superoxide dismutase	890:909	superoxide dismutase	890:909	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	6	68	theme	weight	690:695	arg1	gain					697:700	weight gain	690:700	weight gain	690:700	KRF-7 was observed to positively alter the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish.
34607010	7	69	theme	myeloperoxidase	935:949	arg1	activity					951:958	myeloperoxidase activity	935:958	myeloperoxidase activity	935:958	KRF-7 supplementation showed positive regulation of nonspecific immune parameters, such as superoxide dismutase, lysozyme activity, and myeloperoxidase activity.
34607010	1	70	theme	rockfish	72:79	arg1	intestine					59:67	the intestine	55:67	the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture	55:170	KRF-7 isolated from the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture.
34607010	10	71	with	supplementation	1419:1433	arg1	KRF-7					1440:1444	KRF-7	1440:1444	KRF-7	1440:1444	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	0	72	theme	Bacillus	22:29	arg1	sp					31:32	a Bacillus sp	20:32	a Bacillus sp	20:32	Characterization of a Bacillus sp.
34607010	5	73	theme	feeding	571:577	arg1	trial					579:583	a feeding trial	569:583	a feeding trial	569:583	In a feeding trial, providing a supplemental diet of 1 × 108 CFU g-1Bacillus sp.
34607010	1	74	theme	effects	85:91	arg1	intestine					59:67	the intestine	55:67	the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture	55:170	KRF-7 isolated from the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture.
34607010	10	75	theme	rockfish	1481:1488	arg1	performance					1466:1476	the growth performance	1455:1476	the growth performance of rockfish	1455:1488	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	4	76	dep	in	464:465	arg1	vitro					467:471	vitro	467:471	vitro	467:471	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii) was demonstrated to be safe based on in vitro tests confirming the absence of hemolysis, cytotoxicity, and genes with toxigenic potential.
34607010	4	77	theme	cytotoxicity	516:527	arg1	absence					494:500	the absence	490:500	the absence of hemolysis, cytotoxicity, and genes with toxigenic potential	490:563	KRF-7 isolated from the intestine of rockfish (Sebastes schlegelii) was demonstrated to be safe based on in vitro tests confirming the absence of hemolysis, cytotoxicity, and genes with toxigenic potential.
34607010	8	78	from	change	991:996	arg1	composition					1005:1015	the composition	1001:1015	the composition of the intestinal microbiota	1001:1044	This analysis also revealed a change in the composition of the intestinal microbiota at the phylum level from Proteobacteria to Firmicutes.
34607010	6	79	theme	conversion	730:739	arg1	ratio					741:745	feed conversion ratio	725:745	feed conversion ratio	725:745	KRF-7 was observed to positively alter the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish.
34607010	1	80	from	effects	85:91	arg1	aquaculture					160:170	rockfish aquaculture	151:170	rockfish aquaculture	151:170	KRF-7 isolated from the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture.
34607010	2	81	theme	study	193:197	arg1	purpose					177:183	The purpose	173:183	The purpose of this study	173:197	The purpose of this study was to characterize the bacteria isolated from rockfish intestines and to investigate the effects of feed supplementation in rockfish aquaculture.
34607010	10	82	theme	KRF-7	1347:1351	arg1	safety					1337:1342	the safety	1333:1342	the safety of KRF-7 isolated from the intestine of rockfish	1333:1391	Therefore, this study verified the safety of KRF-7 isolated from the intestine of rockfish and suggests that dietary supplementation with KRF-7 enhances the growth performance of rockfish and has beneficial effects on the regulation of the intestinal microbiota and immune response.
34607010	2	83	theme	rockfish	324:331	arg1	aquaculture					333:343	rockfish aquaculture	324:343	rockfish aquaculture	324:343	The purpose of this study was to characterize the bacteria isolated from rockfish intestines and to investigate the effects of feed supplementation in rockfish aquaculture.
34607010	1	84	from	rockfish	72:79	arg1	aquaculture					160:170	rockfish aquaculture	151:170	rockfish aquaculture	151:170	KRF-7 isolated from the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture.
34607010	9	85	dep	kidney	1113:1118	arg1	the					1109:1111	the	1109:1111	the	1109:1111	In both the kidney and spleen, the expression levels of IL-10, NF-κB, and B cell activating factors in the KRF-7-supplemented group were significantly increased compared to those in the control group.
34607010	6	86	theme	growth	712:717	arg1	rate					719:722	specific growth rate	703:722	specific growth rate	703:722	KRF-7 was observed to positively alter the weight gain, specific growth rate, feed conversion ratio, and protein efficiency ratio of juvenile rockfish.
34607010	1	87	from	intestine	59:67	arg1	aquaculture					160:170	rockfish aquaculture	151:170	rockfish aquaculture	151:170	KRF-7 isolated from the intestine of rockfish and effects of dietary supplementation with mannan oligosaccharide in rockfish aquaculture.
34412473	7	0	theme	immersion	1381:1389	arg1	interface					1350:1358	the metal-coating interface	1332:1358	the metal-coating interface for at least 48 h of immersion	1332:1389	The scanning vibrating electrode technique results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings.
34412473	8	1	theme	transfer	1755:1762	arg1	resistance					1764:1773	the maximum charge transfer resistance	1736:1773	the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel)	1736:1836	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	2	2	theme	aqueous	360:366	arg1	dispersion					368:377	an aqueous dispersion	357:377	an aqueous dispersion of colloidal lignin particles (CLPs)	357:414	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	5	3	from	effects	883:889	arg1	formation					921:929	coating formation	913:929	coating formation	913:929	The effects of these variables on coating formation, dry adhesion, and electrochemical properties (3.5% NaCl) were investigated.
34412473	5	3	from	effects	883:889	arg1	adhesion					936:943	dry adhesion	932:943	dry adhesion	932:943	The effects of these variables on coating formation, dry adhesion, and electrochemical properties (3.5% NaCl) were investigated.
34412473	5	3	from	effects	883:889	arg1	properties					966:975	electrochemical properties	950:975	electrochemical properties (3.5% NaCl)	950:987	The effects of these variables on coating formation, dry adhesion, and electrochemical properties (3.5% NaCl) were investigated.
34412473	5	3	from	effects	883:889	arg1	NaCl					983:986	3.5% NaCl	978:986	3.5% NaCl	978:986	The effects of these variables on coating formation, dry adhesion, and electrochemical properties (3.5% NaCl) were investigated.
34412473	4	4	theme	steel	825:829	arg1	surfaces					831:838	HDG steel surfaces	821:838	HDG steel surfaces at different potentials (0.5 and 3 V)	821:876	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	8	5	theme	increased	1559:1567	arg1	levels					1569:1574	increased levels	1559:1574	increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V)	1559:1693	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	6	6	theme	HDG	1174:1176	arg1	steel					1178:1182	HDG steel	1174:1182	HDG steel	1174:1182	The scanning electron microscopy results showed that coalescence of CLPs occurs during the drying of composite coatings, resulting in formation of a barrier layer on HDG steel.
34412473	6	7	from	layer	1165:1169	arg1	steel					1178:1182	HDG steel	1174:1182	HDG steel	1174:1182	The scanning electron microscopy results showed that coalescence of CLPs occurs during the drying of composite coatings, resulting in formation of a barrier layer on HDG steel.
34412473	6	8	theme	layer	1165:1169	arg1	formation					1142:1150	formation	1142:1150	formation of a barrier layer on HDG steel	1142:1182	The scanning electron microscopy results showed that coalescence of CLPs occurs during the drying of composite coatings, resulting in formation of a barrier layer on HDG steel.
34412473	2	9	theme	kraft	286:290	arg1	lignin					292:297	softwood kraft lignin	277:297	softwood kraft lignin	277:297	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	8	10	theme	HDG	1629:1631	arg1	coatings					1648:1655	bare HDG steel-although coatings	1624:1655	bare HDG steel-although coatings deposited at a higher potential (3 V)	1624:1693	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	7	11	theme	%	1321:1321	arg1	NaCl					1323:1326	3.5% NaCl	1318:1326	3.5% NaCl	1318:1326	The scanning vibrating electrode technique results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings.
34412473	7	11	theme	%	1321:1321	arg1	electrolyte					1305:1315	the electrolyte	1301:1315	the electrolyte (3.5% NaCl)	1301:1327	The scanning vibrating electrode technique results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings.
34412473	8	12	theme	immersion	1792:1800	arg1	days					1784:1787	15 days	1781:1787	15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel)	1781:1836	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	2	13	theme	ether	331:335	arg1	solution					265:272	a solution	263:272	a solution of softwood kraft lignin and diethylene glycol monobutyl ether	263:335	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	5	14	theme	%	981:981	arg1	NaCl					983:986	3.5% NaCl	978:986	3.5% NaCl	978:986	The effects of these variables on coating formation, dry adhesion, and electrochemical properties (3.5% NaCl) were investigated.
34412473	5	14	theme	%	981:981	arg1	properties					966:975	electrochemical properties	950:975	electrochemical properties (3.5% NaCl)	950:987	The effects of these variables on coating formation, dry adhesion, and electrochemical properties (3.5% NaCl) were investigated.
34412473	3	15	theme	colloidal	555:563	arg1	stability					565:573	colloidal stability	555:573	colloidal stability (ζ-potential = -40 mV)	555:596	Analysis of the dispersion showed that it comprised submicron particles (D = 146 nm) with spherical morphologies and colloidal stability (ζ-potential = -40 mV).
34412473	4	16	theme	CLP	635:637	arg1	dispersion					639:648	the CLP dispersion	631:648	the CLP dispersion	631:648	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	8	17	theme	higher	1672:1677	arg1	potential					1679:1687	a higher potential	1670:1687	a higher potential (3 V)	1670:1693	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	8	17	theme	higher	1672:1677	arg1	V					1692:1692	3 V	1690:1692	3 V	1690:1692	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	1	18	theme	electrophoretic	224:238	arg1	deposition					240:249	aqueous electrophoretic deposition	216:249	aqueous electrophoretic deposition	216:249	This study presents a process for preparation of cellulose-lignin barrier coatings for hot-dip galvanized (HDG) steel by aqueous electrophoretic deposition.
34412473	4	19	theme	nanofibers	706:715	arg1	suspension					667:676	a suspension	665:676	a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1)	665:737	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	5	20	theme	electrochemical	950:964	arg1	NaCl					983:986	3.5% NaCl	978:986	3.5% NaCl	978:986	The effects of these variables on coating formation, dry adhesion, and electrochemical properties (3.5% NaCl) were investigated.
34412473	5	20	theme	electrochemical	950:964	arg1	properties					966:975	electrochemical properties	950:975	electrochemical properties (3.5% NaCl)	950:987	The effects of these variables on coating formation, dry adhesion, and electrochemical properties (3.5% NaCl) were investigated.
34412473	4	21	dep	nanofibers	706:715	arg1	g·L-1					732:736	1 and 2 g·L-1	724:736	1 and 2 g·L-1	724:736	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	4	21	dep	nanofibers	706:715	arg1	TOCN					718:721	TOCN	718:721	TOCN	718:721	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	3	22	theme	spherical	528:536	arg1	morphologies					538:549	spherical morphologies	528:549	spherical morphologies	528:549	Analysis of the dispersion showed that it comprised submicron particles (D = 146 nm) with spherical morphologies and colloidal stability (ζ-potential = -40 mV).
34412473	1	23	theme	cellulose-lignin	144:159	arg1	coatings					169:176	cellulose-lignin barrier coatings	144:176	cellulose-lignin barrier coatings	144:176	This study presents a process for preparation of cellulose-lignin barrier coatings for hot-dip galvanized (HDG) steel by aqueous electrophoretic deposition.
34412473	7	24	theme	TOCN-CLP	1258:1265	arg1	layers					1267:1272	the TOCN-CLP layers	1254:1272	the TOCN-CLP layers	1254:1272	The scanning vibrating electrode technique results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings.
34412473	6	25	from	formation	1142:1150	arg1	steel					1178:1182	HDG steel	1174:1182	HDG steel	1174:1182	The scanning electron microscopy results showed that coalescence of CLPs occurs during the drying of composite coatings, resulting in formation of a barrier layer on HDG steel.
34412473	0	26	theme	Lignin	77:82	arg1	Particles					84:92	Colloidal Lignin Particles	67:92	Colloidal Lignin Particles	67:92	Biopolymeric Anticorrosion Coatings from Cellulose Nanofibrils and Colloidal Lignin Particles.
34412473	1	27	theme	coatings	169:176	arg1	preparation					129:139	preparation	129:139	preparation of cellulose-lignin barrier coatings for hot-dip galvanized (HDG) steel by aqueous electrophoretic deposition	129:249	This study presents a process for preparation of cellulose-lignin barrier coatings for hot-dip galvanized (HDG) steel by aqueous electrophoretic deposition.
34412473	4	28	theme	TEMPO-oxidized	681:694	arg1	nanofibers					706:715	TEMPO-oxidized cellulose nanofibers	681:715	TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1)	681:737	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	8	29	theme	higher	1701:1706	arg1	concentration					1713:1725	a higher TOCN concentration	1699:1725	a higher TOCN concentration	1699:1725	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	1	30	theme	hot-dip	182:188	arg1	steel					207:211	hot-dip galvanized (HDG) steel	182:211	hot-dip galvanized (HDG) steel by aqueous electrophoretic deposition	182:249	This study presents a process for preparation of cellulose-lignin barrier coatings for hot-dip galvanized (HDG) steel by aqueous electrophoretic deposition.
34412473	9	31	theme	TOCN-CLP	1889:1896	arg1	composites					1911:1920	TOCN-CLP biopolymeric composites	1889:1920	TOCN-CLP biopolymeric composites	1889:1920	Overall, these results highlight the potential of TOCN-CLP biopolymeric composites as a basis for sustainable corrosion protection coatings.
34412473	7	32	theme	V-deposited	1440:1450	arg1	coatings					1452:1459	3 V-deposited coatings	1438:1459	3 V-deposited coatings	1438:1459	The scanning vibrating electrode technique results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings.
34412473	9	33	theme	composites	1911:1920	arg1	basis					1927:1931	a basis	1925:1931	a basis for sustainable corrosion protection coatings	1925:1977	Overall, these results highlight the potential of TOCN-CLP biopolymeric composites as a basis for sustainable corrosion protection coatings.
34412473	9	33	theme	composites	1911:1920	arg1	potential					1876:1884	the potential	1872:1884	the potential of TOCN-CLP biopolymeric composites	1872:1920	Overall, these results highlight the potential of TOCN-CLP biopolymeric composites as a basis for sustainable corrosion protection coatings.
34412473	5	34	theme	variables	900:908	arg1	effects					883:889	The effects	879:889	The effects of these variables on coating formation, dry adhesion, and electrochemical properties (3.5% NaCl)	879:987	The effects of these variables on coating formation, dry adhesion, and electrochemical properties (3.5% NaCl) were investigated.
34412473	2	35	theme	particles	399:407	arg1	dispersion					368:377	an aqueous dispersion	357:377	an aqueous dispersion of colloidal lignin particles (CLPs)	357:414	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	0	36	theme	Biopolymeric	0:11	arg1	Coatings					27:34	Biopolymeric Anticorrosion Coatings	0:34	Biopolymeric Anticorrosion Coatings from Cellulose Nanofibrils and Colloidal Lignin Particles	0:92	Biopolymeric Anticorrosion Coatings from Cellulose Nanofibrils and Colloidal Lignin Particles.
34412473	8	37	theme	charge	1748:1753	arg1	resistance					1764:1773	the maximum charge transfer resistance	1736:1773	the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel)	1736:1836	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	6	38	theme	composite	1109:1117	arg1	coatings					1119:1126	composite coatings	1109:1126	composite coatings	1109:1126	The scanning electron microscopy results showed that coalescence of CLPs occurs during the drying of composite coatings, resulting in formation of a barrier layer on HDG steel.
34412473	5	39	theme	dry	932:934	arg1	adhesion					936:943	dry adhesion	932:943	dry adhesion	932:943	The effects of these variables on coating formation, dry adhesion, and electrochemical properties (3.5% NaCl) were investigated.
34412473	9	40	theme	corrosion	1949:1957	arg1	coatings					1970:1977	sustainable corrosion protection coatings	1937:1977	sustainable corrosion protection coatings	1937:1977	Overall, these results highlight the potential of TOCN-CLP biopolymeric composites as a basis for sustainable corrosion protection coatings.
34412473	3	41	theme	dispersion	454:463	arg1	Analysis					438:445	Analysis	438:445	Analysis of the dispersion	438:463	Analysis of the dispersion showed that it comprised submicron particles (D = 146 nm) with spherical morphologies and colloidal stability (ζ-potential = -40 mV).
34412473	0	42	theme	Cellulose	41:49	arg1	Nanofibrils					51:61	Cellulose Nanofibrils	41:61	Cellulose Nanofibrils	41:61	Biopolymeric Anticorrosion Coatings from Cellulose Nanofibrils and Colloidal Lignin Particles.
34412473	7	43	theme	prolonged	1404:1412	arg1	performance					1422:1432	a more prolonged barrier performance	1397:1432	a more prolonged barrier performance for 3 V-deposited coatings	1397:1459	The scanning vibrating electrode technique results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings.
34412473	7	44	theme	vibrating	1198:1206	arg1	technique					1218:1226	The scanning vibrating electrode technique	1185:1226	The scanning vibrating electrode technique	1185:1226	The scanning vibrating electrode technique results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings.
34412473	8	45	theme	Additional	1462:1471	arg1	studies					1512:1518	Additional electrochemical impedance spectroscopy studies	1462:1518	Additional electrochemical impedance spectroscopy studies	1462:1518	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	8	46	theme	impedance	1489:1497	arg1	studies					1512:1518	Additional electrochemical impedance spectroscopy studies	1462:1518	Additional electrochemical impedance spectroscopy studies	1462:1518	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	4	47	theme	volumetric	750:759	arg1	ratio					761:765	a fixed volumetric ratio	742:765	a fixed volumetric ratio (1:1, TOCN-CLPs)	742:782	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	4	47	theme	volumetric	750:759	arg1	1:1					768:770	1:1	768:770	1:1	768:770	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	6	48	from	steel	1178:1182	arg1	formation					1142:1150	formation	1142:1150	formation of a barrier layer on HDG steel	1142:1182	The scanning electron microscopy results showed that coalescence of CLPs occurs during the drying of composite coatings, resulting in formation of a barrier layer on HDG steel.
34412473	5	49	theme	coating	913:919	arg1	formation					921:929	coating formation	913:929	coating formation	913:929	The effects of these variables on coating formation, dry adhesion, and electrochemical properties (3.5% NaCl) were investigated.
34412473	6	50	theme	electron	1021:1028	arg1	microscopy					1030:1039	scanning electron microscopy	1012:1039	The scanning electron microscopy results	1008:1047	The scanning electron microscopy results showed that coalescence of CLPs occurs during the drying of composite coatings, resulting in formation of a barrier layer on HDG steel.
34412473	2	51	theme	colloidal	382:390	arg1	CLPs					410:413	CLPs	410:413	CLPs	410:413	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	2	51	theme	colloidal	382:390	arg1	particles					399:407	colloidal lignin particles	382:407	colloidal lignin particles (CLPs)	382:414	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	8	52	theme	charge	1579:1584	arg1	Rct					1607:1609	Rct	1607:1609	Rct	1607:1609	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	8	52	theme	charge	1579:1584	arg1	resistance					1595:1604	charge transfer resistance	1579:1604	charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V)	1579:1693	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	3	53	theme	D	511:511	arg1	particles					500:508	submicron particles	490:508	submicron particles (D = 146 nm)	490:521	Analysis of the dispersion showed that it comprised submicron particles (D = 146 nm) with spherical morphologies and colloidal stability (ζ-potential = -40 mV).
34412473	3	53	theme	D	511:511	arg1	nm					519:520	D = 146 nm	511:520	D = 146 nm	511:520	Analysis of the dispersion showed that it comprised submicron particles (D = 146 nm) with spherical morphologies and colloidal stability (ζ-potential = -40 mV).
34412473	8	54	theme	resistance	1595:1604	arg1	levels					1569:1574	increased levels	1559:1574	increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V)	1559:1693	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	2	55	theme	diethylene	303:312	arg1	ether					331:335	diethylene glycol monobutyl ether	303:335	diethylene glycol monobutyl ether	303:335	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	6	56	theme	CLPs	1076:1079	arg1	coalescence					1061:1071	coalescence	1061:1071	coalescence of CLPs	1061:1079	The scanning electron microscopy results showed that coalescence of CLPs occurs during the drying of composite coatings, resulting in formation of a barrier layer on HDG steel.
34412473	4	57	theme	HDG	821:823	arg1	surfaces					831:838	HDG steel surfaces	821:838	HDG steel surfaces at different potentials (0.5 and 3 V)	821:876	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	7	58	theme	metal-coating	1336:1348	arg1	interface					1350:1358	the metal-coating interface	1332:1358	the metal-coating interface for at least 48 h of immersion	1332:1389	The scanning vibrating electrode technique results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings.
34412473	2	59	theme	lignin	292:297	arg1	solution					265:272	a solution	263:272	a solution of softwood kraft lignin and diethylene glycol monobutyl ether	263:335	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	8	60	theme	-compared	1611:1619	arg1	Rct					1607:1609	Rct	1607:1609	Rct	1607:1609	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	8	60	theme	-compared	1611:1619	arg1	resistance					1595:1604	charge transfer resistance	1579:1604	charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V)	1579:1693	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	1	61	theme	galvanized	190:199	arg1	steel					207:211	hot-dip galvanized (HDG) steel	182:211	hot-dip galvanized (HDG) steel by aqueous electrophoretic deposition	182:249	This study presents a process for preparation of cellulose-lignin barrier coatings for hot-dip galvanized (HDG) steel by aqueous electrophoretic deposition.
34412473	6	62	theme	barrier	1157:1163	arg1	layer					1165:1169	a barrier layer	1155:1169	a barrier layer on HDG steel	1155:1182	The scanning electron microscopy results showed that coalescence of CLPs occurs during the drying of composite coatings, resulting in formation of a barrier layer on HDG steel.
34412473	8	63	theme	bare	1624:1627	arg1	coatings					1648:1655	bare HDG steel-although coatings	1624:1655	bare HDG steel-although coatings deposited at a higher potential (3 V)	1624:1693	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	1	64	theme	HDG	202:204	arg1	steel					207:211	hot-dip galvanized (HDG) steel	182:211	hot-dip galvanized (HDG) steel by aqueous electrophoretic deposition	182:249	This study presents a process for preparation of cellulose-lignin barrier coatings for hot-dip galvanized (HDG) steel by aqueous electrophoretic deposition.
34412473	2	65	theme	monobutyl	321:329	arg1	ether					331:335	diethylene glycol monobutyl ether	303:335	diethylene glycol monobutyl ether	303:335	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	8	66	theme	steel-although	1633:1646	arg1	coatings					1648:1655	bare HDG steel-although coatings	1624:1655	bare HDG steel-although coatings deposited at a higher potential (3 V)	1624:1693	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	1	67	theme	aqueous	216:222	arg1	deposition					240:249	aqueous electrophoretic deposition	216:249	aqueous electrophoretic deposition	216:249	This study presents a process for preparation of cellulose-lignin barrier coatings for hot-dip galvanized (HDG) steel by aqueous electrophoretic deposition.
34412473	0	68	from	Particles	84:92	arg1	Coatings					27:34	Biopolymeric Anticorrosion Coatings	0:34	Biopolymeric Anticorrosion Coatings from Cellulose Nanofibrils and Colloidal Lignin Particles	0:92	Biopolymeric Anticorrosion Coatings from Cellulose Nanofibrils and Colloidal Lignin Particles.
34412473	7	69	theme	electrolyte	1305:1315	arg1	penetration					1286:1296	the penetration	1282:1296	the penetration of the electrolyte (3.5% NaCl)	1282:1327	The scanning vibrating electrode technique results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings.
34412473	8	70	theme	HDG	1827:1829	arg1	steel					1831:1835	HDG steel	1827:1835	HDG steel	1827:1835	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	4	71	theme	cellulose	696:704	arg1	nanofibers					706:715	TEMPO-oxidized cellulose nanofibers	681:715	TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1)	681:737	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	2	72	theme	softwood	277:284	arg1	lignin					292:297	softwood kraft lignin	277:297	softwood kraft lignin	277:297	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	4	73	theme	different	843:851	arg1	V					875:875	0.5 and 3 V	865:875	0.5 and 3 V	865:875	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	4	73	theme	different	843:851	arg1	potentials					853:862	different potentials	843:862	different potentials (0.5 and 3 V)	843:876	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	6	74	theme	coatings	1119:1126	arg1	drying					1099:1104	the drying	1095:1104	the drying of composite coatings	1095:1126	The scanning electron microscopy results showed that coalescence of CLPs occurs during the drying of composite coatings, resulting in formation of a barrier layer on HDG steel.
34412473	1	75	theme	barrier	161:167	arg1	coatings					169:176	cellulose-lignin barrier coatings	144:176	cellulose-lignin barrier coatings	144:176	This study presents a process for preparation of cellulose-lignin barrier coatings for hot-dip galvanized (HDG) steel by aqueous electrophoretic deposition.
34412473	8	76	dep	immersion	1792:1800	arg1	13.7					1803:1806	13.7	1803:1806	13.7	1803:1806	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	3	77	dep	stability	565:573	arg1	=					588:588	=	588:588	=	588:588	Analysis of the dispersion showed that it comprised submicron particles (D = 146 nm) with spherical morphologies and colloidal stability (ζ-potential = -40 mV).
34412473	2	78	theme	glycol	314:319	arg1	ether					331:335	diethylene glycol monobutyl ether	303:335	diethylene glycol monobutyl ether	303:335	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	9	79	theme	biopolymeric	1898:1909	arg1	composites					1911:1920	TOCN-CLP biopolymeric composites	1889:1920	TOCN-CLP biopolymeric composites	1889:1920	Overall, these results highlight the potential of TOCN-CLP biopolymeric composites as a basis for sustainable corrosion protection coatings.
34412473	8	80	theme	TOCN	1708:1711	arg1	concentration					1713:1725	a higher TOCN concentration	1699:1725	a higher TOCN concentration	1699:1725	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	0	81	from	Nanofibrils	51:61	arg1	Coatings					27:34	Biopolymeric Anticorrosion Coatings	0:34	Biopolymeric Anticorrosion Coatings from Cellulose Nanofibrils and Colloidal Lignin Particles	0:92	Biopolymeric Anticorrosion Coatings from Cellulose Nanofibrils and Colloidal Lignin Particles.
34412473	2	82	used	used	341:344	arg2	solution					265:272	a solution	263:272	a solution of softwood kraft lignin and diethylene glycol monobutyl ether	263:335	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	0	83	theme	Anticorrosion	13:25	arg1	Coatings					27:34	Biopolymeric Anticorrosion Coatings	0:34	Biopolymeric Anticorrosion Coatings from Cellulose Nanofibrils and Colloidal Lignin Particles	0:92	Biopolymeric Anticorrosion Coatings from Cellulose Nanofibrils and Colloidal Lignin Particles.
34412473	2	84	theme	lignin	392:397	arg1	CLPs					410:413	CLPs	410:413	CLPs	410:413	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	2	84	theme	lignin	392:397	arg1	particles					399:407	colloidal lignin particles	382:407	colloidal lignin particles (CLPs)	382:414	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	8	85	theme	maximum	1740:1746	arg1	resistance					1764:1773	the maximum charge transfer resistance	1736:1773	the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel)	1736:1836	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	4	86	from	potentials	853:862	arg1	surfaces					831:838	HDG steel surfaces	821:838	HDG steel surfaces at different potentials (0.5 and 3 V)	821:876	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	7	87	theme	electrode	1208:1216	arg1	technique					1218:1226	The scanning vibrating electrode technique	1185:1226	The scanning vibrating electrode technique	1185:1226	The scanning vibrating electrode technique results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings.
34412473	9	88	theme	sustainable	1937:1947	arg1	coatings					1970:1977	sustainable corrosion protection coatings	1937:1977	sustainable corrosion protection coatings	1937:1977	Overall, these results highlight the potential of TOCN-CLP biopolymeric composites as a basis for sustainable corrosion protection coatings.
34412473	2	89	theme	solvent	420:426	arg1	exchange					428:435	solvent exchange	420:435	solvent exchange	420:435	Initially, a solution of softwood kraft lignin and diethylene glycol monobutyl ether was used to prepare an aqueous dispersion of colloidal lignin particles (CLPs) via solvent exchange.
34412473	7	90	dep	results	1228:1234	arg1	demonstrated					1236:1247	demonstrated	1236:1247	results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings	1228:1459	The scanning vibrating electrode technique results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings.
34412473	7	91	theme	scanning	1189:1196	arg1	technique					1218:1226	The scanning vibrating electrode technique	1185:1226	The scanning vibrating electrode technique	1185:1226	The scanning vibrating electrode technique results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings.
34412473	8	92	theme	electrochemical	1473:1487	arg1	studies					1512:1518	Additional electrochemical impedance spectroscopy studies	1462:1518	Additional electrochemical impedance spectroscopy studies	1462:1518	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	9	93	theme	protection	1959:1968	arg1	coatings					1970:1977	sustainable corrosion protection coatings	1937:1977	sustainable corrosion protection coatings	1937:1977	Overall, these results highlight the potential of TOCN-CLP biopolymeric composites as a basis for sustainable corrosion protection coatings.
34412473	0	94	theme	Colloidal	67:75	arg1	Particles					84:92	Colloidal Lignin Particles	67:92	Colloidal Lignin Particles	67:92	Biopolymeric Anticorrosion Coatings from Cellulose Nanofibrils and Colloidal Lignin Particles.
34412473	7	95	theme	barrier	1414:1420	arg1	performance					1422:1432	a more prolonged barrier performance	1397:1432	a more prolonged barrier performance for 3 V-deposited coatings	1397:1459	The scanning vibrating electrode technique results demonstrated that the TOCN-CLP layers reduced the penetration of the electrolyte (3.5% NaCl) to the metal-coating interface for at least 48 h of immersion, with a more prolonged barrier performance for 3 V-deposited coatings.
34412473	8	96	dep	13.7	1803:1806	arg1	cf.					1808:1810	cf.	1808:1810	cf. 0.2 kΩ·cm2 for HDG steel	1808:1835	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	8	97	theme	spectroscopy	1499:1510	arg1	studies					1512:1518	Additional electrochemical impedance spectroscopy studies	1462:1518	Additional electrochemical impedance spectroscopy studies	1462:1518	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	3	98	theme	=	513:513	arg1	particles					500:508	submicron particles	490:508	submicron particles (D = 146 nm)	490:521	Analysis of the dispersion showed that it comprised submicron particles (D = 146 nm) with spherical morphologies and colloidal stability (ζ-potential = -40 mV).
34412473	3	98	theme	=	513:513	arg1	nm					519:520	D = 146 nm	511:520	D = 146 nm	511:520	Analysis of the dispersion showed that it comprised submicron particles (D = 146 nm) with spherical morphologies and colloidal stability (ζ-potential = -40 mV).
34412473	6	99	theme	microscopy	1030:1039	arg1	results					1041:1047	The scanning electron microscopy results	1008:1047	The scanning electron microscopy results	1008:1047	The scanning electron microscopy results showed that coalescence of CLPs occurs during the drying of composite coatings, resulting in formation of a barrier layer on HDG steel.
34412473	4	100	theme	fixed	744:748	arg1	ratio					761:765	a fixed volumetric ratio	742:765	a fixed volumetric ratio (1:1, TOCN-CLPs)	742:782	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	4	100	theme	fixed	744:748	arg1	1:1					768:770	1:1	768:770	1:1	768:770	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	3	101	theme	submicron	490:498	arg1	particles					500:508	submicron particles	490:508	submicron particles (D = 146 nm)	490:521	Analysis of the dispersion showed that it comprised submicron particles (D = 146 nm) with spherical morphologies and colloidal stability (ζ-potential = -40 mV).
34412473	3	101	theme	submicron	490:498	arg1	nm					519:520	D = 146 nm	511:520	D = 146 nm	511:520	Analysis of the dispersion showed that it comprised submicron particles (D = 146 nm) with spherical morphologies and colloidal stability (ζ-potential = -40 mV).
34412473	8	102	theme	transfer	1586:1593	arg1	Rct					1607:1609	Rct	1607:1609	Rct	1607:1609	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	8	102	theme	transfer	1586:1593	arg1	resistance					1595:1604	charge transfer resistance	1579:1604	charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V)	1579:1693	Additional electrochemical impedance spectroscopy studies showed that all four coatings provided increased levels of charge transfer resistance (Rct)-compared to bare HDG steel-although coatings deposited at a higher potential (3 V) and a higher TOCN concentration provided the maximum charge transfer resistance after 15 days of immersion (13.7 cf. 0.2 kΩ·cm2 for HDG steel).
34412473	4	103	dep	1:1	768:770	arg1	TOCN-CLPs					773:781	TOCN-CLPs	773:781	TOCN-CLPs	773:781	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
34412473	6	104	theme	scanning	1012:1019	arg1	microscopy					1030:1039	scanning electron microscopy	1012:1039	The scanning electron microscopy results	1008:1047	The scanning electron microscopy results showed that coalescence of CLPs occurs during the drying of composite coatings, resulting in formation of a barrier layer on HDG steel.
34412473	4	105	theme	successful	609:618	arg1	formation					620:628	successful formation	609:628	successful formation	609:628	Following successful formation, the CLP dispersion was mixed with a suspension of TEMPO-oxidized cellulose nanofibers (TOCN, 1 and 2 g·L-1) at a fixed volumetric ratio (1:1, TOCN-CLPs), and biopolymers were deposited onto HDG steel surfaces at different potentials (0.5 and 3 V).
33035527	0	0	theme	active	100:105	arg1	nanorods					114:121	active silica nanorods	100:121	active silica nanorods derived from natural palygorskite	100:155	An upgraded and universal strategy to reinforce chitosan/polyvinylpyrrolidone film by incorporating active silica nanorods derived from natural palygorskite.
33035527	3	1	with	dispersion	864:873	arg1	network					949:955	3D polymer network	938:955	3D polymer network	938:955	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	2	2	theme	mechanical	590:599	arg1	properties					601:610	mechanical properties	590:610	mechanical properties	590:610	It was revealed that OPal had a better dispersibility than RPal in CS/PVP substrate, and its incorporation improved the mechanical properties and thermal stability of the films significantly.
33035527	3	3	theme	maximum	715:721	arg1	strength					731:738	the maximum tensile strength	711:738	the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively)	711:829	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	3	4	theme	tensile	723:729	arg1	strength					731:738	the maximum tensile strength	711:738	the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively)	711:829	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	1	5	theme	acid	250:253	arg1	route					264:268	an updated acid leaching route	239:268	an updated acid leaching route	239:268	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	3	6	dep	27.53 MPa	743:751	arg1	22.47 MPa					773:781	22.47 MPa	773:781	22.47 MPa for CS/PVP and CS/PVP/RPal films	773:814	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	3	6	dep	27.53 MPa	743:751	arg1	14.87 MPa					759:767	only 14.87 MPa	754:767	only 14.87 MPa	754:767	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	1	7	theme	CS/PVP	429:434	arg1	films					437:441	chitosan/polyvinylpyrrolidone (CS/PVP) films	398:441	chitosan/polyvinylpyrrolidone (CS/PVP) films	398:441	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	3	8	theme	uniform	856:862	arg1	dispersion					864:873	the more uniform dispersion	847:873	the more uniform dispersion of OPal in polymer substrate	847:902	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	1	9	theme	leaching	255:262	arg1	route					264:268	an updated acid leaching route	239:268	an updated acid leaching route	239:268	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	4	10	theme	metal	1140:1144	arg1	ions					1146:1149	variable metal ions	1131:1149	variable metal ions	1131:1149	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	2	11	theme	films	641:645	arg1	properties					601:610	mechanical properties	590:610	mechanical properties	590:610	It was revealed that OPal had a better dispersibility than RPal in CS/PVP substrate, and its incorporation improved the mechanical properties and thermal stability of the films significantly.
33035527	2	11	theme	films	641:645	arg1	stability					624:632	thermal stability	616:632	thermal stability	616:632	It was revealed that OPal had a better dispersibility than RPal in CS/PVP substrate, and its incorporation improved the mechanical properties and thermal stability of the films significantly.
33035527	4	12	theme	aging-resistant	1212:1226	arg1	ability					1228:1234	the aging-resistant ability	1208:1234	the aging-resistant ability of films	1208:1243	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	4	13	theme	ions	1146:1149	arg1	effects					1120:1126	the adverse effects	1108:1126	the adverse effects of variable metal ions on the film under UV light irradiation	1108:1188	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	4	14	theme	controllable	963:974	arg1	process					990:996	a controllable acid-leaching process	961:996	a controllable acid-leaching process	961:996	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	0	15	theme	silica	107:112	arg1	nanorods					114:121	active silica nanorods	100:121	active silica nanorods derived from natural palygorskite	100:155	An upgraded and universal strategy to reinforce chitosan/polyvinylpyrrolidone film by incorporating active silica nanorods derived from natural palygorskite.
33035527	1	16	theme	network	330:336	arg1	structure					338:346	the network structure	326:346	the network structure	326:346	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	5	17	theme	clay	1476:1479	arg1	minerals					1481:1488	natural clay minerals	1468:1488	natural clay minerals	1468:1488	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	1	18	theme	films	437:441	arg1	effect					284:289	the effect	280:289	the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films	280:441	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	5	19	theme	clay	1325:1328	arg1	minerals					1330:1337	natural clay minerals	1317:1337	natural clay minerals	1317:1337	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	3	20	theme	substrate	894:902	arg1	dispersion					864:873	the more uniform dispersion	847:873	the more uniform dispersion of OPal in polymer substrate	847:902	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	3	20	theme	substrate	894:902	arg1	interaction					921:931	its stronger interaction	908:931	its stronger interaction with 3D polymer network	908:955	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	5	21	theme	aging	1405:1409	arg1	problem					1411:1417	the aging problem	1401:1417	the aging problem of polymer composites caused by incorporation of natural clay minerals	1401:1488	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	4	22	theme	adverse	1112:1118	arg1	effects					1120:1126	the adverse effects	1108:1126	the adverse effects of variable metal ions on the film under UV light irradiation	1108:1188	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	5	23	theme	polymer	1422:1428	arg1	composites					1430:1439	polymer composites	1422:1439	polymer composites caused by incorporation of natural clay minerals	1422:1488	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	3	24	theme	OPal	878:881	arg1	substrate					894:902	OPal in polymer substrate	878:902	OPal in polymer substrate	878:902	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	5	25	dep	provides	1257:1264	arg1	finds					1374:1378	finds	1374:1378	finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals	1374:1488	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	2	26	theme	thermal	616:622	arg1	stability					624:632	thermal stability	616:632	thermal stability	616:632	It was revealed that OPal had a better dispersibility than RPal in CS/PVP substrate, and its incorporation improved the mechanical properties and thermal stability of the films significantly.
33035527	5	27	theme	new	1382:1384	arg1	way					1386:1388	a new way	1380:1388	a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals	1380:1488	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	3	28	from	OPal	878:881	arg1	polymer					886:892	polymer	886:892	polymer	886:892	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	4	29	from	effects	1120:1126	arg1	film					1158:1161	the film	1154:1161	the film under UV light irradiation	1154:1188	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	0	30	theme	upgraded	3:10	arg1	strategy					26:33	An upgraded and universal strategy	0:33	An upgraded and universal strategy	0:33	An upgraded and universal strategy to reinforce chitosan/polyvinylpyrrolidone film by incorporating active silica nanorods derived from natural palygorskite.
33035527	1	31	theme	mechanical	349:358	arg1	properties					384:393	RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties	294:393	RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties	294:393	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	4	32	theme	light	1172:1176	arg1	irradiation					1178:1188	UV light irradiation	1169:1188	UV light irradiation	1169:1188	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	5	33	theme	natural	1317:1323	arg1	minerals					1330:1337	natural clay minerals	1317:1337	natural clay minerals	1317:1337	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	2	34	dep	properties	601:610	arg1	the					586:588	the	586:588	the	586:588	It was revealed that OPal had a better dispersibility than RPal in CS/PVP substrate, and its incorporation improved the mechanical properties and thermal stability of the films significantly.
33035527	5	35	theme	minerals	1330:1337	arg1	ability					1306:1312	the reinforcing ability	1290:1312	the reinforcing ability of natural clay minerals towards biopolymer-based material	1290:1371	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	3	36	theme	optimal	666:672	arg1	film					684:687	The optimal composite film	662:687	The optimal composite film containing OPal	662:703	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	0	37	theme	universal	16:24	arg1	strategy					26:33	An upgraded and universal strategy	0:33	An upgraded and universal strategy	0:33	An upgraded and universal strategy to reinforce chitosan/polyvinylpyrrolidone film by incorporating active silica nanorods derived from natural palygorskite.
33035527	3	38	theme	only	754:757	arg1	14.87 MPa					759:767	only 14.87 MPa	754:767	only 14.87 MPa	754:767	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	2	39	theme	CS/PVP	537:542	arg1	substrate					544:552	CS/PVP substrate	537:552	CS/PVP substrate	537:552	It was revealed that OPal had a better dispersibility than RPal in CS/PVP substrate, and its incorporation improved the mechanical properties and thermal stability of the films significantly.
33035527	4	40	dep	dissolved	1048:1056	arg1	out					1058:1060	out	1058:1060	out	1058:1060	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	1	41	theme	natural	205:211	arg1	palygorskite					213:224	natural palygorskite	205:224	natural palygorskite (RPal)	205:231	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	1	41	theme	natural	205:211	arg1	RPal					227:230	RPal	227:230	RPal	227:230	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	4	42	theme	octahedral	1017:1026	arg1	sheets					1028:1033	octahedral sheets	1017:1033	octahedral sheets of RPal	1017:1041	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	0	43	theme	natural	136:142	arg1	palygorskite					144:155	natural palygorskite	136:155	natural palygorskite	136:155	An upgraded and universal strategy to reinforce chitosan/polyvinylpyrrolidone film by incorporating active silica nanorods derived from natural palygorskite.
33035527	1	44	dep	nanorod	172:178	arg1	OPal					181:184	OPal	181:184	OPal	181:184	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	5	45	theme	reinforcing	1294:1304	arg1	ability					1306:1312	the reinforcing ability	1290:1312	the reinforcing ability of natural clay minerals towards biopolymer-based material	1290:1371	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	3	46	contain	containing	689:698	arg1	film					684:687	The optimal composite film	662:687	The optimal composite film containing OPal	662:703	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	3	46	contain	containing	689:698	arg2	OPal					700:703	OPal	700:703	OPal	700:703	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	4	47	from	ions	1009:1012	arg1	sheets					1028:1033	octahedral sheets	1017:1033	octahedral sheets of RPal	1017:1041	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	3	48	theme	27.53 MPa	743:751	arg1	strength					731:738	the maximum tensile strength	711:738	the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively)	711:829	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	1	49	theme	thermal	361:367	arg1	properties					384:393	RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties	294:393	RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties	294:393	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	3	50	theme	stronger	912:919	arg1	interaction					921:931	its stronger interaction	908:931	its stronger interaction with 3D polymer network	908:955	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	3	51	with	interaction	921:931	arg1	network					949:955	3D polymer network	938:955	3D polymer network	938:955	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	4	52	dep	alleviate	1098:1106	arg1	improve					1200:1206	improve	1200:1206	improve the aging-resistant ability of films	1200:1243	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	0	53	theme	chitosan/polyvinylpyrrolidone	48:76	arg1	film					78:81	chitosan/polyvinylpyrrolidone film	48:81	chitosan/polyvinylpyrrolidone film	48:81	An upgraded and universal strategy to reinforce chitosan/polyvinylpyrrolidone film by incorporating active silica nanorods derived from natural palygorskite.
33035527	1	54	theme	RPal	294:297	arg1	properties					384:393	RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties	294:393	RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties	294:393	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	5	55	theme	minerals	1481:1488	arg1	incorporation					1451:1463	incorporation	1451:1463	incorporation of natural clay minerals	1451:1488	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	1	56	theme	anti-aging	373:382	arg1	properties					384:393	RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties	294:393	RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties	294:393	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	2	57	theme	better	502:507	arg1	dispersibility					509:522	a better dispersibility	500:522	a better dispersibility	500:522	It was revealed that OPal had a better dispersibility than RPal in CS/PVP substrate, and its incorporation improved the mechanical properties and thermal stability of the films significantly.
33035527	1	58	theme	properties	384:393	arg1	effect					284:289	the effect	280:289	the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films	280:441	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	5	59	theme	composites	1430:1439	arg1	problem					1411:1417	the aging problem	1401:1417	the aging problem of polymer composites caused by incorporation of natural clay minerals	1401:1488	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	3	60	theme	3D	938:939	arg1	network					949:955	3D polymer network	938:955	3D polymer network	938:955	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	5	61	theme	natural	1468:1474	arg1	minerals					1481:1488	natural clay minerals	1468:1488	natural clay minerals	1468:1488	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	1	62	theme	OPal	303:306	arg1	properties					384:393	RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties	294:393	RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties	294:393	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	3	63	theme	composite	674:682	arg1	film					684:687	The optimal composite film	662:687	The optimal composite film containing OPal	662:703	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	3	64	theme	polymer	941:947	arg1	network					949:955	3D polymer network	938:955	3D polymer network	938:955	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	5	65	theme	biopolymer-based	1347:1362	arg1	material					1364:1371	biopolymer-based material	1347:1371	biopolymer-based material	1347:1371	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	4	66	theme	UV	1169:1170	arg1	irradiation					1178:1188	UV light irradiation	1169:1188	UV light irradiation	1169:1188	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	2	67	from	RPal	529:532	arg1	substrate					544:552	CS/PVP substrate	537:552	CS/PVP substrate	537:552	It was revealed that OPal had a better dispersibility than RPal in CS/PVP substrate, and its incorporation improved the mechanical properties and thermal stability of the films significantly.
33035527	1	68	theme	chitosan/polyvinylpyrrolidone	398:426	arg1	films					437:441	chitosan/polyvinylpyrrolidone (CS/PVP) films	398:441	chitosan/polyvinylpyrrolidone (CS/PVP) films	398:441	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	3	69	from	polymer	886:892	arg1	OPal					878:881	OPal	878:881	OPal	878:881	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	2	70	contain	had	496:498	arg2	dispersibility					509:522	a better dispersibility	500:522	a better dispersibility	500:522	It was revealed that OPal had a better dispersibility than RPal in CS/PVP substrate, and its incorporation improved the mechanical properties and thermal stability of the films significantly.
33035527	2	70	contain	had	496:498	arg1	OPal					491:494	OPal	491:494	OPal	491:494	It was revealed that OPal had a better dispersibility than RPal in CS/PVP substrate, and its incorporation improved the mechanical properties and thermal stability of the films significantly.
33035527	1	71	theme	Active	158:163	arg1	nanorod					172:178	Active silica nanorod	158:178	Active silica nanorod (OPal)	158:185	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	4	72	theme	films	1239:1243	arg1	ability					1228:1234	the aging-resistant ability	1208:1234	the aging-resistant ability of films	1208:1243	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	4	73	theme	variable	1131:1138	arg1	ions					1146:1149	variable metal ions	1131:1149	variable metal ions	1131:1149	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	1	74	theme	silica	165:170	arg1	nanorod					172:178	Active silica nanorod	158:178	Active silica nanorod (OPal)	158:185	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33035527	5	75	theme	new	1266:1268	arg1	ideas					1270:1274	new ideas	1266:1274	new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material	1266:1371	This study provides new ideas for improving the reinforcing ability of natural clay minerals towards biopolymer-based material, finds a new way to resolve the aging problem of polymer composites caused by incorporation of natural clay minerals.
33035527	3	76	theme	CS/PVP	787:792	arg1	films					810:814	CS/PVP and CS/PVP/RPal films	787:814	CS/PVP and CS/PVP/RPal films	787:814	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	4	77	theme	metal	1003:1007	arg1	ions					1009:1012	the metal ions	999:1012	the metal ions in octahedral sheets of RPal	999:1041	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	4	78	theme	acid-leaching	976:988	arg1	process					990:996	a controllable acid-leaching process	961:996	a controllable acid-leaching process	961:996	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	0	79	attach	derived	123:129	arg2	nanorods					114:121	active silica nanorods	100:121	active silica nanorods derived from natural palygorskite	100:155	An upgraded and universal strategy to reinforce chitosan/polyvinylpyrrolidone film by incorporating active silica nanorods derived from natural palygorskite.
33035527	0	79	attach	derived	123:129	arg1	palygorskite					144:155	natural palygorskite	136:155	natural palygorskite	136:155	An upgraded and universal strategy to reinforce chitosan/polyvinylpyrrolidone film by incorporating active silica nanorods derived from natural palygorskite.
33035527	3	80	theme	CS/PVP/RPal	798:808	arg1	films					810:814	CS/PVP and CS/PVP/RPal films	787:814	CS/PVP and CS/PVP/RPal films	787:814	The optimal composite film containing OPal shows the maximum tensile strength of 27.53 MPa (only 14.87 MPa and 22.47 MPa for CS/PVP and CS/PVP/RPal films, respectively), resulting from the more uniform dispersion of OPal in polymer substrate and its stronger interaction with 3D polymer network.
33035527	4	81	theme	RPal	1038:1041	arg1	sheets					1028:1033	octahedral sheets	1017:1033	octahedral sheets of RPal	1017:1041	By a controllable acid-leaching process, the metal ions in octahedral sheets of RPal were dissolved out continuously, which is favorable to alleviate the adverse effects of variable metal ions on the film under UV light irradiation, and thus improve the aging-resistant ability of films.
33035527	1	82	theme	updated	242:248	arg1	route					264:268	an updated acid leaching route	239:268	an updated acid leaching route	239:268	Active silica nanorod (OPal) was prepared from natural palygorskite (RPal) using an updated acid leaching route, and then the effect of RPal and OPal as nano-filler on the network structure, mechanical, thermal and anti-aging properties of chitosan/polyvinylpyrrolidone (CS/PVP) films was studied comparatively.
33774369	11	0	contain	containing	2038:2047	arg2	acid					2068:2071	α2,6-linked sialic acid	2049:2071	α2,6-linked sialic acid	2049:2071	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	0	contain	containing	2038:2047	arg1	glycans					2030:2036	glycans	2030:2036	glycans containing α2,6-linked sialic acid	2030:2071	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	13	1	theme	SP	2305:2306	arg1	treatment					2308:2316	SP treatment	2305:2316	SP treatment	2305:2316	These results indicate that SP treatment affects the glycan composition of the dromedary camel ES glycocalyx.
33774369	9	2	theme	single	1413:1418	arg1	antigen					1454:1460	Tn antigen	1451:1460	Tn antigen	1451:1460	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	9	2	theme	single	1413:1418	arg1	residue					1442:1448	a single N-acetylgalactosamine residue	1411:1448	a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA)	1411:1536	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	8	3	theme	N-glycans	1214:1222	arg1	presence					1198:1205	the presence	1194:1205	the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120)	1194:1278	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	6	4	theme	surface	932:938	arg1	profiles					940:947	Post-thaw carbohydrate surface profiles	909:947	Post-thaw carbohydrate surface profiles of both control and SP-treated spermatozoa	909:990	Post-thaw carbohydrate surface profiles of both control and SP-treated spermatozoa were analyzed using 15 fluorescent lectins.
33774369	4	5	theme	Epididymal	602:611	arg1	sperm					613:617	Epididymal sperm	602:617	Epididymal sperm	602:617	Epididymal sperm was collected through retrograde flushing of the cauda epididymidis that were obtained from orchidectomized mature dromedary bulls.
33774369	10	6	dep	N-acetylglucosamine	1597:1615	arg1	GSA					1627:1629	GSA II	1627:1632	GSA II	1627:1632	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues was also noted in the acrosomal cap region of control sperm.
33774369	10	6	dep	N-acetylglucosamine	1597:1615	arg1	sWGA					1618:1621	sWGA	1618:1621	sWGA	1618:1621	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues was also noted in the acrosomal cap region of control sperm.
33774369	3	7	theme	surface	540:546	arg1	patterns					562:569	the surface glycosylation patterns	536:569	the surface glycosylation patterns of cryopreserved dromedary ES	536:599	Since the sperm glycocalyx plays a key role in reproduction we aimed to evaluate whether SP exposure modifies the surface glycosylation patterns of cryopreserved dromedary ES.
33774369	6	8	theme	Post-thaw	909:917	arg1	profiles					940:947	Post-thaw carbohydrate surface profiles	909:947	Post-thaw carbohydrate surface profiles of both control and SP-treated spermatozoa	909:990	Post-thaw carbohydrate surface profiles of both control and SP-treated spermatozoa were analyzed using 15 fluorescent lectins.
33774369	11	9	theme	α2,6-linked	2049:2059	arg1	acid					2068:2071	α2,6-linked sialic acid	2049:2071	α2,6-linked sialic acid	2049:2071	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	10	theme	complex-type	1839:1850	arg1	PHA-E					1863:1867	PHA-E	1863:1867	PHA-E	1863:1867	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	10	theme	complex-type	1839:1850	arg1	N-glycans					1852:1860	bisected di-triantennary complex-type N-glycans	1814:1860	bisected di-triantennary complex-type N-glycans (PHA-E)	1814:1868	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	11	link	α2,6-linked	2049:2059	arg1	acid					2068:2071	α2,6-linked sialic acid	2049:2071	α2,6-linked sialic acid	2049:2071	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	4	12	theme	epididymidis	674:685	arg1	flushing					652:659	retrograde flushing	641:659	retrograde flushing of the cauda epididymidis that were obtained from orchidectomized mature dromedary bulls	641:748	Epididymal sperm was collected through retrograde flushing of the cauda epididymidis that were obtained from orchidectomized mature dromedary bulls.
33774369	11	13	from	N-acetylglucosamine	2074:2092	arg1	region					2122:2127	the tail region	2113:2127	the tail region	2113:2127	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	13	from	N-acetylglucosamine	2074:2092	arg1	glycans					2030:2036	glycans	2030:2036	glycans containing α2,6-linked sialic acid	2030:2071	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	13	14	theme	camel	2366:2370	arg1	glycocalyx					2375:2384	the dromedary camel ES glycocalyx	2352:2384	the dromedary camel ES glycocalyx	2352:2384	These results indicate that SP treatment affects the glycan composition of the dromedary camel ES glycocalyx.
33774369	0	15	theme	Seminal	0:6	arg1	plasma					8:13	Seminal plasma	0:13	Seminal plasma	0:13	Seminal plasma Alters surface Glycoprofile of dromedary camel cryopreserved epididymal spermatozoa.
33774369	9	16	theme	Tn	1451:1452	arg1	antigen					1454:1460	Tn antigen	1451:1460	Tn antigen	1451:1460	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	9	16	theme	Tn	1451:1452	arg1	residue					1442:1448	a single N-acetylgalactosamine residue	1411:1448	a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA)	1411:1536	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	10	17	theme	sperm	1732:1736	arg1	region					1714:1719	the acrosomal cap region	1696:1719	the acrosomal cap region of control sperm	1696:1736	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues was also noted in the acrosomal cap region of control sperm.
33774369	13	18	theme	glycocalyx	2375:2384	arg1	composition					2337:2347	the glycan composition	2326:2347	the glycan composition of the dromedary camel ES glycocalyx	2326:2384	These results indicate that SP treatment affects the glycan composition of the dromedary camel ES glycocalyx.
33774369	3	19	theme	cryopreserved	574:586	arg1	ES					598:599	cryopreserved dromedary ES	574:599	cryopreserved dromedary ES	574:599	Since the sperm glycocalyx plays a key role in reproduction we aimed to evaluate whether SP exposure modifies the surface glycosylation patterns of cryopreserved dromedary ES.
33774369	5	20	theme	%	903:903	arg1	SP					905:906	15% SP	901:906	15% SP	901:906	The collected samples were then cryopreserved after dilution with a tris citrate clarified egg yolk extender, with and without the supplementation of 15% SP.
33774369	8	21	theme	acrosomal	1289:1297	arg1	regions					1308:1314	both acrosomal and tail regions	1284:1314	regions	1308:1314	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	11	22	theme	T	1961:1961	arg1	antigens					1963:1970	T antigens	1961:1970	T antigens	1961:1970	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	1	23	theme	reproduction	210:221	arg1	technology					223:232	assisted reproduction technology	201:232	assisted reproduction technology	201:232	The high viscosity of Camelidae semen continues to present a major impediment for its application in assisted reproduction technology.
33774369	11	24	theme	N-glycans	1852:1860	arg1	N-acetylglucosamine					2074:2092	N-acetylglucosamine	2074:2092	N-acetylglucosamine	2074:2092	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	24	theme	N-glycans	1852:1860	arg1	αgalactose					2099:2108	αgalactose	2099:2108	αgalactose	2099:2108	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	24	theme	N-glycans	1852:1860	arg1	increase					2018:2025	an increase	2015:2025	2) an increase in glycans containing α2,6-linked sialic acid	2012:2071	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	24	theme	N-glycans	1852:1860	arg1	increase					1915:1922	an increase	1912:1922	an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions	1912:2009	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	24	theme	N-glycans	1852:1860	arg1	appearance					1800:1809	the appearance	1796:1809	: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region	1791:2127	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	8	25	theme	tail	1303:1306	arg1	regions					1308:1314	both acrosomal and tail regions	1284:1314	regions	1308:1314	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	10	26	theme	N-acetylglucosamine	1597:1615	arg1	expression					1578:1587	The expression	1574:1587	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues	1574:1676	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues was also noted in the acrosomal cap region of control sperm.
33774369	6	27	theme	SP-treated	969:978	arg1	spermatozoa					980:990	both control and SP-treated spermatozoa	952:990	both control and SP-treated spermatozoa	952:990	Post-thaw carbohydrate surface profiles of both control and SP-treated spermatozoa were analyzed using 15 fluorescent lectins.
33774369	11	28	theme	SP	1763:1764	arg1	samples					1774:1780	SP treated samples	1763:1780	SP treated samples	1763:1780	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	7	29	theme	sperm	1110:1114	arg1	analysis					1116:1123	computer assisted sperm analysis	1092:1123	computer assisted sperm analysis	1092:1123	Morpho-functional properties were also investigated via computer assisted sperm analysis.
33774369	3	30	theme	ES	598:599	arg1	patterns					562:569	the surface glycosylation patterns	536:569	the surface glycosylation patterns of cryopreserved dromedary ES	536:599	Since the sperm glycocalyx plays a key role in reproduction we aimed to evaluate whether SP exposure modifies the surface glycosylation patterns of cryopreserved dromedary ES.
33774369	1	31	theme	semen	132:136	arg1	viscosity					109:117	The high viscosity	100:117	The high viscosity of Camelidae semen	100:136	The high viscosity of Camelidae semen continues to present a major impediment for its application in assisted reproduction technology.
33774369	6	32	theme	control	957:963	arg1	spermatozoa					980:990	both control and SP-treated spermatozoa	952:990	both control and SP-treated spermatozoa	952:990	Post-thaw carbohydrate surface profiles of both control and SP-treated spermatozoa were analyzed using 15 fluorescent lectins.
33774369	11	33	theme	tail	1998:2001	arg1	regions					2003:2009	tail regions	1998:2009	tail regions	1998:2009	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	9	34	dep	residue	1442:1448	arg1	HPA					1464:1466	HPA	1464:1466	HPA	1464:1466	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	9	34	dep	residue	1442:1448	arg1	SBA					1469:1471	SBA	1469:1471	SBA	1469:1471	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	5	35	with	dilution	803:810	arg1	extender					851:858	a tris citrate clarified egg yolk extender	817:858	a tris citrate clarified egg yolk extender	817:858	The collected samples were then cryopreserved after dilution with a tris citrate clarified egg yolk extender, with and without the supplementation of 15% SP.
33774369	6	36	gly	carbohydrate	919:930	arg1	spermatozoa					980:990	both control and SP-treated spermatozoa	952:990	both control and SP-treated spermatozoa	952:990	Post-thaw carbohydrate surface profiles of both control and SP-treated spermatozoa were analyzed using 15 fluorescent lectins.
33774369	7	37	theme	computer	1092:1099	arg1	analysis					1116:1123	computer assisted sperm analysis	1092:1123	computer assisted sperm analysis	1092:1123	Morpho-functional properties were also investigated via computer assisted sperm analysis.
33774369	1	38	from	application	186:196	arg1	technology					223:232	assisted reproduction technology	201:232	assisted reproduction technology	201:232	The high viscosity of Camelidae semen continues to present a major impediment for its application in assisted reproduction technology.
33774369	8	39	from	glycocalyx	1157:1166	arg1	sperm					1179:1183	control sperm	1171:1183	control sperm	1171:1183	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	0	40	theme	cryopreserved	62:74	arg1	spermatozoa					87:97	dromedary camel cryopreserved epididymal spermatozoa	46:97	dromedary camel cryopreserved epididymal spermatozoa	46:97	Seminal plasma Alters surface Glycoprofile of dromedary camel cryopreserved epididymal spermatozoa.
33774369	2	41	theme	spermatozoa	262:272	arg1	exposure					239:246	The exposure	235:246	The exposure of epididymal spermatozoa (ES) to seminal plasma (SP)	235:300	The exposure of epididymal spermatozoa (ES) to seminal plasma (SP) may provide an approach to enhance the development of assisted reproductive techniques in these important domestic species.
33774369	9	42	theme	T	1521:1521	arg1	galactoseβ1,3N-acetylgalactosamine					1485:1518	galactoseβ1,3N-acetylgalactosamine	1485:1518	a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA)	1411:1536	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	9	42	theme	T	1521:1521	arg1	antigen					1523:1529	T antigen	1521:1529	T antigen	1521:1529	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	8	43	theme	glycocalyx	1157:1166	arg1	analysis					1141:1148	Lectin-binding analysis	1126:1148	Lectin-binding analysis of the glycocalyx in control sperm	1126:1183	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	11	44	theme	tail	2117:2120	arg1	region					2122:2127	the tail region	2113:2127	the tail region	2113:2127	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	12	45	theme	sperm	2198:2202	arg1	droplets					2146:2153	The cytoplasmic droplets	2130:2153	The cytoplasmic droplets of both control and seminal plasma-treated sperm	2130:2202	The cytoplasmic droplets of both control and seminal plasma-treated sperm bound Con A, PHA-E, PHA-L, RCA120, HPA, PNA, sWGA, GSA I-B4, and GSA II.
33774369	4	46	theme	mature	727:732	arg1	bulls					744:748	orchidectomized mature dromedary bulls	711:748	orchidectomized mature dromedary bulls	711:748	Epididymal sperm was collected through retrograde flushing of the cauda epididymidis that were obtained from orchidectomized mature dromedary bulls.
33774369	0	47	theme	spermatozoa	87:97	arg1	surface					22:28	surface Glycoprofile	22:41	surface Glycoprofile of dromedary camel cryopreserved epididymal spermatozoa	22:97	Seminal plasma Alters surface Glycoprofile of dromedary camel cryopreserved epididymal spermatozoa.
33774369	12	48	theme	Con	2210:2212	arg1	A					2214:2214	Con A	2210:2214	Con A	2210:2214	The cytoplasmic droplets of both control and seminal plasma-treated sperm bound Con A, PHA-E, PHA-L, RCA120, HPA, PNA, sWGA, GSA I-B4, and GSA II.
33774369	8	49	dep	N-glycans	1214:1222	arg1	1					1211:1211	1	1211:1211	1	1211:1211	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	10	50	theme	cap	1710:1712	arg1	region					1714:1719	the acrosomal cap region	1696:1719	the acrosomal cap region of control sperm	1696:1736	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues was also noted in the acrosomal cap region of control sperm.
33774369	9	51	link	α2,3-/α2,6-linked	1328:1344	arg1	MALII					1360:1364	MALII	1360:1364	MALII	1360:1364	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	9	51	link	α2,3-/α2,6-linked	1328:1344	arg1	acids					1353:1357	α2,3-/α2,6-linked sialic acids	1328:1357	(2) α2,3-/α2,6-linked sialic acids (MALII, SNA)	1324:1370	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	6	52	theme	fluorescent	1015:1025	arg1	lectins					1027:1033	15 fluorescent lectins	1012:1033	15 fluorescent lectins	1012:1033	Post-thaw carbohydrate surface profiles of both control and SP-treated spermatozoa were analyzed using 15 fluorescent lectins.
33774369	12	53	theme	control	2163:2169	arg1	droplets					2146:2153	The cytoplasmic droplets	2130:2153	The cytoplasmic droplets of both control and seminal plasma-treated sperm	2130:2202	The cytoplasmic droplets of both control and seminal plasma-treated sperm bound Con A, PHA-E, PHA-L, RCA120, HPA, PNA, sWGA, GSA I-B4, and GSA II.
33774369	11	54	from	increase	2018:2025	arg1	region					2122:2127	the tail region	2113:2127	the tail region	2113:2127	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	54	from	increase	2018:2025	arg1	glycans					2030:2036	glycans	2030:2036	glycans containing α2,6-linked sialic acid	2030:2071	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	3	55	theme	sperm	436:440	arg1	glycocalyx					442:451	the sperm glycocalyx	432:451	the sperm glycocalyx	432:451	Since the sperm glycocalyx plays a key role in reproduction we aimed to evaluate whether SP exposure modifies the surface glycosylation patterns of cryopreserved dromedary ES.
33774369	9	56	theme	α2,3-/α2,6-linked	1328:1344	arg1	MALII					1360:1364	MALII	1360:1364	MALII	1360:1364	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	9	56	theme	α2,3-/α2,6-linked	1328:1344	arg1	acids					1353:1357	α2,3-/α2,6-linked sialic acids	1328:1357	(2) α2,3-/α2,6-linked sialic acids (MALII, SNA)	1324:1370	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	12	57	theme	seminal	2175:2181	arg1	sperm					2198:2202	seminal plasma-treated sperm	2175:2202	seminal plasma-treated sperm	2175:2202	The cytoplasmic droplets of both control and seminal plasma-treated sperm bound Con A, PHA-E, PHA-L, RCA120, HPA, PNA, sWGA, GSA I-B4, and GSA II.
33774369	2	58	theme	techniques	378:387	arg1	development					341:351	the development	337:351	the development of assisted reproductive techniques in these important domestic species	337:423	The exposure of epididymal spermatozoa (ES) to seminal plasma (SP) may provide an approach to enhance the development of assisted reproductive techniques in these important domestic species.
33774369	5	59	theme	yolk	846:849	arg1	extender					851:858	a tris citrate clarified egg yolk extender	817:858	a tris citrate clarified egg yolk extender	817:858	The collected samples were then cryopreserved after dilution with a tris citrate clarified egg yolk extender, with and without the supplementation of 15% SP.
33774369	8	60	theme	Lectin-binding	1126:1139	arg1	analysis					1141:1148	Lectin-binding analysis	1126:1148	Lectin-binding analysis of the glycocalyx in control sperm	1126:1183	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	1	61	theme	high	104:107	arg1	viscosity					109:117	The high viscosity	100:117	The high viscosity of Camelidae semen	100:136	The high viscosity of Camelidae semen continues to present a major impediment for its application in assisted reproduction technology.
33774369	3	62	theme	key	461:463	arg1	role					465:468	a key role	459:468	a key role	459:468	Since the sperm glycocalyx plays a key role in reproduction we aimed to evaluate whether SP exposure modifies the surface glycosylation patterns of cryopreserved dromedary ES.
33774369	10	63	theme	acrosomal	1700:1708	arg1	region					1714:1719	the acrosomal cap region	1696:1719	the acrosomal cap region of control sperm	1696:1736	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues was also noted in the acrosomal cap region of control sperm.
33774369	9	64	theme	acrosomal	1559:1567	arg1	cap					1569:1571	the acrosomal cap	1555:1571	the acrosomal cap	1555:1571	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	0	65	theme	Glycoprofile	30:41	arg1	surface					22:28	surface Glycoprofile	22:41	surface Glycoprofile of dromedary camel cryopreserved epididymal spermatozoa	22:97	Seminal plasma Alters surface Glycoprofile of dromedary camel cryopreserved epididymal spermatozoa.
33774369	5	66	theme	tris	819:822	arg1	extender					851:858	a tris citrate clarified egg yolk extender	817:858	a tris citrate clarified egg yolk extender	817:858	The collected samples were then cryopreserved after dilution with a tris citrate clarified egg yolk extender, with and without the supplementation of 15% SP.
33774369	14	67	theme	More	2387:2390	arg1	studies					2406:2412	More comprehensive studies	2387:2412	More comprehensive studies	2387:2412	More comprehensive studies are required in order to evaluate the fertilization capacity of SP-treated ES in order to facilitate its application in dromedary camel assisted reproduction technology.
33774369	10	68	theme	residues	1669:1676	arg1	expression					1578:1587	The expression	1574:1587	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues	1574:1676	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues was also noted in the acrosomal cap region of control sperm.
33774369	5	69	theme	clarified	832:840	arg1	extender					851:858	a tris citrate clarified egg yolk extender	817:858	a tris citrate clarified egg yolk extender	817:858	The collected samples were then cryopreserved after dilution with a tris citrate clarified egg yolk extender, with and without the supplementation of 15% SP.
33774369	8	70	theme	control	1171:1177	arg1	sperm					1179:1183	control sperm	1171:1183	control sperm	1171:1183	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	14	71	theme	reproduction	2559:2570	arg1	technology					2572:2581	dromedary camel assisted reproduction technology	2534:2581	dromedary camel assisted reproduction technology	2534:2581	More comprehensive studies are required in order to evaluate the fertilization capacity of SP-treated ES in order to facilitate its application in dromedary camel assisted reproduction technology.
33774369	9	72	theme	O-linked	1377:1384	arg1	glycans					1386:1392	O-linked glycans	1377:1392	O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA)	1377:1536	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	14	73	theme	camel	2544:2548	arg1	technology					2572:2581	dromedary camel assisted reproduction technology	2534:2581	dromedary camel assisted reproduction technology	2534:2581	More comprehensive studies are required in order to evaluate the fertilization capacity of SP-treated ES in order to facilitate its application in dromedary camel assisted reproduction technology.
33774369	2	74	theme	assisted	356:363	arg1	techniques					378:387	assisted reproductive techniques	356:387	assisted reproductive techniques	356:387	The exposure of epididymal spermatozoa (ES) to seminal plasma (SP) may provide an approach to enhance the development of assisted reproductive techniques in these important domestic species.
33774369	0	75	theme	camel	56:60	arg1	spermatozoa					87:97	dromedary camel cryopreserved epididymal spermatozoa	46:97	dromedary camel cryopreserved epididymal spermatozoa	46:97	Seminal plasma Alters surface Glycoprofile of dromedary camel cryopreserved epididymal spermatozoa.
33774369	11	76	from	αgalactose	2099:2108	arg1	region					2122:2127	the tail region	2113:2127	the tail region	2113:2127	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	76	from	αgalactose	2099:2108	arg1	glycans					2030:2036	glycans	2030:2036	glycans containing α2,6-linked sialic acid	2030:2071	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	9	77	theme	N-acetylgalactosamine	1420:1440	arg1	antigen					1454:1460	Tn antigen	1451:1460	Tn antigen	1451:1460	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	9	77	theme	N-acetylgalactosamine	1420:1440	arg1	residue					1442:1448	a single N-acetylgalactosamine residue	1411:1448	a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA)	1411:1536	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	6	78	theme	carbohydrate	919:930	arg1	profiles					940:947	Post-thaw carbohydrate surface profiles	909:947	Post-thaw carbohydrate surface profiles of both control and SP-treated spermatozoa	909:990	Post-thaw carbohydrate surface profiles of both control and SP-treated spermatozoa were analyzed using 15 fluorescent lectins.
33774369	9	79	dep	observed	1543:1550	arg1	Whilst					1317:1322	Whilst	1317:1322	Whilst	1317:1322	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	13	80	theme	dromedary	2356:2364	arg1	glycocalyx					2375:2384	the dromedary camel ES glycocalyx	2352:2384	the dromedary camel ES glycocalyx	2352:2384	These results indicate that SP treatment affects the glycan composition of the dromedary camel ES glycocalyx.
33774369	2	81	theme	seminal	282:288	arg1	plasma					290:295	seminal plasma	282:295	seminal plasma (SP)	282:300	The exposure of epididymal spermatozoa (ES) to seminal plasma (SP) may provide an approach to enhance the development of assisted reproductive techniques in these important domestic species.
33774369	2	81	theme	seminal	282:288	arg1	SP					298:299	SP	298:299	SP	298:299	The exposure of epididymal spermatozoa (ES) to seminal plasma (SP) may provide an approach to enhance the development of assisted reproductive techniques in these important domestic species.
33774369	0	82	theme	dromedary	46:54	arg1	spermatozoa					87:97	dromedary camel cryopreserved epididymal spermatozoa	46:97	dromedary camel cryopreserved epididymal spermatozoa	46:97	Seminal plasma Alters surface Glycoprofile of dromedary camel cryopreserved epididymal spermatozoa.
33774369	11	83	theme	sialic	2061:2066	arg1	acid					2068:2071	α2,6-linked sialic acid	2049:2071	α2,6-linked sialic acid	2049:2071	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	2	84	from	development	341:351	arg1	species					417:423	these important domestic species	392:423	these important domestic species	392:423	The exposure of epididymal spermatozoa (ES) to seminal plasma (SP) may provide an approach to enhance the development of assisted reproductive techniques in these important domestic species.
33774369	11	85	from	increase	1915:1922	arg1	region					2122:2127	the tail region	2113:2127	the tail region	2113:2127	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	85	from	increase	1915:1922	arg1	glycans					2030:2036	glycans	2030:2036	glycans containing α2,6-linked sialic acid	2030:2071	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	4	86	theme	cauda	668:672	arg1	epididymidis					674:685	the cauda epididymidis	664:685	the cauda epididymidis that were obtained from orchidectomized mature dromedary bulls	664:748	Epididymal sperm was collected through retrograde flushing of the cauda epididymidis that were obtained from orchidectomized mature dromedary bulls.
33774369	13	87	theme	ES	2372:2373	arg1	glycocalyx					2375:2384	the dromedary camel ES glycocalyx	2352:2384	the dromedary camel ES glycocalyx	2352:2384	These results indicate that SP treatment affects the glycan composition of the dromedary camel ES glycocalyx.
33774369	5	88	theme	15	901:902	arg1	%					903:903	%	903:903	%	903:903	The collected samples were then cryopreserved after dilution with a tris citrate clarified egg yolk extender, with and without the supplementation of 15% SP.
33774369	9	89	link	O-linked	1377:1384	arg1	glycans					1386:1392	O-linked glycans	1377:1392	O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA)	1377:1536	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	11	90	dep	increase	2018:2025	arg1	2					2012:2012	2	2012:2012	2	2012:2012	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	13	91	theme	glycan	2330:2335	arg1	composition					2337:2347	the glycan composition	2326:2347	the glycan composition of the dromedary camel ES glycocalyx	2326:2384	These results indicate that SP treatment affects the glycan composition of the dromedary camel ES glycocalyx.
33774369	3	92	theme	glycosylation	548:560	arg1	patterns					562:569	the surface glycosylation patterns	536:569	the surface glycosylation patterns of cryopreserved dromedary ES	536:599	Since the sperm glycocalyx plays a key role in reproduction we aimed to evaluate whether SP exposure modifies the surface glycosylation patterns of cryopreserved dromedary ES.
33774369	1	93	theme	assisted	201:208	arg1	technology					223:232	assisted reproduction technology	201:232	assisted reproduction technology	201:232	The high viscosity of Camelidae semen continues to present a major impediment for its application in assisted reproduction technology.
33774369	8	94	theme	Con	1254:1256	arg1	A					1258:1258	Con A	1254:1258	Con A	1254:1258	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	4	95	theme	retrograde	641:650	arg1	flushing					652:659	retrograde flushing	641:659	retrograde flushing of the cauda epididymidis that were obtained from orchidectomized mature dromedary bulls	641:748	Epididymal sperm was collected through retrograde flushing of the cauda epididymidis that were obtained from orchidectomized mature dromedary bulls.
33774369	2	96	theme	epididymal	251:260	arg1	ES					275:276	ES	275:276	ES	275:276	The exposure of epididymal spermatozoa (ES) to seminal plasma (SP) may provide an approach to enhance the development of assisted reproductive techniques in these important domestic species.
33774369	2	96	theme	epididymal	251:260	arg1	spermatozoa					262:272	epididymal spermatozoa	251:272	epididymal spermatozoa (ES)	251:277	The exposure of epididymal spermatozoa (ES) to seminal plasma (SP) may provide an approach to enhance the development of assisted reproductive techniques in these important domestic species.
33774369	6	97	theme	spermatozoa	980:990	arg1	profiles					940:947	Post-thaw carbohydrate surface profiles	909:947	Post-thaw carbohydrate surface profiles of both control and SP-treated spermatozoa	909:990	Post-thaw carbohydrate surface profiles of both control and SP-treated spermatozoa were analyzed using 15 fluorescent lectins.
33774369	11	98	theme	O-glycans	1927:1935	arg1	N-acetylglucosamine					2074:2092	N-acetylglucosamine	2074:2092	N-acetylglucosamine	2074:2092	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	98	theme	O-glycans	1927:1935	arg1	αgalactose					2099:2108	αgalactose	2099:2108	αgalactose	2099:2108	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	98	theme	O-glycans	1927:1935	arg1	increase					2018:2025	an increase	2015:2025	2) an increase in glycans containing α2,6-linked sialic acid	2012:2071	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	98	theme	O-glycans	1927:1935	arg1	increase					1915:1922	an increase	1912:1922	an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions	1912:2009	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	98	theme	O-glycans	1927:1935	arg1	appearance					1800:1809	the appearance	1796:1809	: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region	1791:2127	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	7	99	theme	assisted	1101:1108	arg1	analysis					1116:1123	computer assisted sperm analysis	1092:1123	computer assisted sperm analysis	1092:1123	Morpho-functional properties were also investigated via computer assisted sperm analysis.
33774369	3	100	theme	dromedary	588:596	arg1	ES					598:599	cryopreserved dromedary ES	574:599	cryopreserved dromedary ES	574:599	Since the sperm glycocalyx plays a key role in reproduction we aimed to evaluate whether SP exposure modifies the surface glycosylation patterns of cryopreserved dromedary ES.
33774369	1	101	theme	Camelidae	122:130	arg1	semen					132:136	Camelidae semen	122:136	Camelidae semen	122:136	The high viscosity of Camelidae semen continues to present a major impediment for its application in assisted reproduction technology.
33774369	4	102	theme	dromedary	734:742	arg1	bulls					744:748	orchidectomized mature dromedary bulls	711:748	orchidectomized mature dromedary bulls	711:748	Epididymal sperm was collected through retrograde flushing of the cauda epididymidis that were obtained from orchidectomized mature dromedary bulls.
33774369	11	103	theme	treated	1766:1772	arg1	samples					1774:1780	SP treated samples	1763:1780	SP treated samples	1763:1780	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	10	104	theme	control	1724:1730	arg1	sperm					1732:1736	control sperm	1724:1736	control sperm	1724:1736	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues was also noted in the acrosomal cap region of control sperm.
33774369	11	105	theme	di-triantennary	1823:1837	arg1	PHA-E					1863:1867	PHA-E	1863:1867	PHA-E	1863:1867	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	105	theme	di-triantennary	1823:1837	arg1	N-glycans					1852:1860	bisected di-triantennary complex-type N-glycans	1814:1860	bisected di-triantennary complex-type N-glycans (PHA-E)	1814:1868	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	3	106	gly	glycosylation	548:560	arg1	ES					598:599	cryopreserved dromedary ES	574:599	cryopreserved dromedary ES	574:599	Since the sperm glycocalyx plays a key role in reproduction we aimed to evaluate whether SP exposure modifies the surface glycosylation patterns of cryopreserved dromedary ES.
33774369	0	107	theme	epididymal	76:85	arg1	spermatozoa					87:97	dromedary camel cryopreserved epididymal spermatozoa	46:97	dromedary camel cryopreserved epididymal spermatozoa	46:97	Seminal plasma Alters surface Glycoprofile of dromedary camel cryopreserved epididymal spermatozoa.
33774369	7	108	theme	Morpho-functional	1036:1052	arg1	properties					1054:1063	Morpho-functional properties	1036:1063	Morpho-functional properties	1036:1063	Morpho-functional properties were also investigated via computer assisted sperm analysis.
33774369	5	109	theme	SP	905:906	arg1	supplementation					882:896	the supplementation	878:896	the supplementation of 15% SP	878:906	The collected samples were then cryopreserved after dilution with a tris citrate clarified egg yolk extender, with and without the supplementation of 15% SP.
33774369	9	110	dep	MALII	1360:1364	arg1	SNA					1367:1369	SNA	1367:1369	SNA	1367:1369	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	14	111	from	application	2519:2529	arg1	technology					2572:2581	dromedary camel assisted reproduction technology	2534:2581	dromedary camel assisted reproduction technology	2534:2581	More comprehensive studies are required in order to evaluate the fertilization capacity of SP-treated ES in order to facilitate its application in dromedary camel assisted reproduction technology.
33774369	1	112	theme	major	161:165	arg1	impediment					167:176	a major impediment	159:176	a major impediment for its application in assisted reproduction technology	159:232	The high viscosity of Camelidae semen continues to present a major impediment for its application in assisted reproduction technology.
33774369	9	113	dep	acids	1353:1357	arg1	2					1325:1325	2	1325:1325	2	1325:1325	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	11	114	from	appearance	1800:1809	arg1	region					2122:2127	the tail region	2113:2127	the tail region	2113:2127	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	114	from	appearance	1800:1809	arg1	glycans					2030:2036	glycans	2030:2036	glycans containing α2,6-linked sialic acid	2030:2071	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	4	115	theme	orchidectomized	711:725	arg1	bulls					744:748	orchidectomized mature dromedary bulls	711:748	orchidectomized mature dromedary bulls	711:748	Epididymal sperm was collected through retrograde flushing of the cauda epididymidis that were obtained from orchidectomized mature dromedary bulls.
33774369	5	116	theme	collected	755:763	arg1	samples					765:771	The collected samples	751:771	The collected samples	751:771	The collected samples were then cryopreserved after dilution with a tris citrate clarified egg yolk extender, with and without the supplementation of 15% SP.
33774369	8	117	from	sperm	1179:1183	arg1	analysis					1141:1148	Lectin-binding analysis	1126:1148	Lectin-binding analysis of the glycocalyx in control sperm	1126:1183	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	9	118	located	observed	1543:1550	arg2	acids					1353:1357	α2,3-/α2,6-linked sialic acids	1328:1357	(2) α2,3-/α2,6-linked sialic acids (MALII, SNA)	1324:1370	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	9	118	located	observed	1543:1550	arg1	cap					1569:1571	the acrosomal cap	1555:1571	the acrosomal cap	1555:1571	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	9	118	located	observed	1543:1550	arg2	glycans					1386:1392	O-linked glycans	1377:1392	O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA)	1377:1536	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	9	118	located	observed	1543:1550	arg2	MALII					1360:1364	MALII	1360:1364	MALII	1360:1364	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	12	119	theme	cytoplasmic	2134:2144	arg1	droplets					2146:2153	The cytoplasmic droplets	2130:2153	The cytoplasmic droplets of both control and seminal plasma-treated sperm	2130:2202	The cytoplasmic droplets of both control and seminal plasma-treated sperm bound Con A, PHA-E, PHA-L, RCA120, HPA, PNA, sWGA, GSA I-B4, and GSA II.
33774369	14	120	theme	ES	2489:2490	arg1	capacity					2466:2473	the fertilization capacity	2448:2473	the fertilization capacity of SP-treated ES	2448:2490	More comprehensive studies are required in order to evaluate the fertilization capacity of SP-treated ES in order to facilitate its application in dromedary camel assisted reproduction technology.
33774369	12	121	theme	plasma-treated	2183:2196	arg1	sperm					2198:2202	seminal plasma-treated sperm	2175:2202	seminal plasma-treated sperm	2175:2202	The cytoplasmic droplets of both control and seminal plasma-treated sperm bound Con A, PHA-E, PHA-L, RCA120, HPA, PNA, sWGA, GSA I-B4, and GSA II.
33774369	9	122	dep	along	1474:1478	arg1	with					1480:1483	with	1480:1483	with	1480:1483	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	5	123	theme	egg	842:844	arg1	extender					851:858	a tris citrate clarified egg yolk extender	817:858	a tris citrate clarified egg yolk extender	817:858	The collected samples were then cryopreserved after dilution with a tris citrate clarified egg yolk extender, with and without the supplementation of 15% SP.
33774369	9	124	theme	sialic	1346:1351	arg1	MALII					1360:1364	MALII	1360:1364	MALII	1360:1364	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	9	124	theme	sialic	1346:1351	arg1	acids					1353:1357	α2,3-/α2,6-linked sialic acids	1328:1357	(2) α2,3-/α2,6-linked sialic acids (MALII, SNA)	1324:1370	Whilst (2) α2,3-/α2,6-linked sialic acids (MALII, SNA), and O-linked glycans terminating with a single N-acetylgalactosamine residue (Tn antigen) (HPA, SBA) along with galactoseβ1,3N-acetylgalactosamine (T antigen) (PNA) were observed in the acrosomal cap.
33774369	11	125	dep	appearance	1800:1809	arg1	1					1793:1793	1	1793:1793	1	1793:1793	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	126	theme	bisected	1814:1821	arg1	PHA-E					1863:1867	PHA-E	1863:1867	PHA-E	1863:1867	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	11	126	theme	bisected	1814:1821	arg1	N-glycans					1852:1860	bisected di-triantennary complex-type N-glycans	1814:1860	bisected di-triantennary complex-type N-glycans (PHA-E)	1814:1868	Compared with controls, SP treated samples displayed: 1) the appearance of bisected di-triantennary complex-type N-glycans (PHA-E), terminating with lactosamine, as well as an increase of O-glycans terminating with Tn and T antigens in both the acrosomal and tail regions; 2) an increase in glycans containing α2,6-linked sialic acid, N-acetylglucosamine, and αgalactose in the tail region.
33774369	2	127	theme	reproductive	365:376	arg1	techniques					378:387	assisted reproductive techniques	356:387	assisted reproductive techniques	356:387	The exposure of epididymal spermatozoa (ES) to seminal plasma (SP) may provide an approach to enhance the development of assisted reproductive techniques in these important domestic species.
33774369	10	128	theme	terminalαgalactose	1639:1656	arg1	residues					1669:1676	both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues	1592:1676	residues	1669:1676	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues was also noted in the acrosomal cap region of control sperm.
33774369	10	128	theme	terminalαgalactose	1639:1656	arg1	I-B4					1663:1666	GSA I-B4	1659:1666	GSA I-B4	1659:1666	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues was also noted in the acrosomal cap region of control sperm.
33774369	14	129	theme	comprehensive	2392:2404	arg1	studies					2406:2412	More comprehensive studies	2387:2412	More comprehensive studies	2387:2412	More comprehensive studies are required in order to evaluate the fertilization capacity of SP-treated ES in order to facilitate its application in dromedary camel assisted reproduction technology.
33774369	2	130	dep	important	398:406	arg1	domestic					408:415	domestic	408:415	domestic	408:415	The exposure of epididymal spermatozoa (ES) to seminal plasma (SP) may provide an approach to enhance the development of assisted reproductive techniques in these important domestic species.
33774369	2	131	theme	important	398:406	arg1	species					417:423	these important domestic species	392:423	these important domestic species	392:423	The exposure of epididymal spermatozoa (ES) to seminal plasma (SP) may provide an approach to enhance the development of assisted reproductive techniques in these important domestic species.
33774369	5	132	theme	citrate	824:830	arg1	extender					851:858	a tris citrate clarified egg yolk extender	817:858	a tris citrate clarified egg yolk extender	817:858	The collected samples were then cryopreserved after dilution with a tris citrate clarified egg yolk extender, with and without the supplementation of 15% SP.
33774369	8	133	from	analysis	1141:1148	arg1	sperm					1179:1183	control sperm	1171:1183	control sperm	1171:1183	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	14	134	theme	fertilization	2452:2464	arg1	capacity					2466:2473	the fertilization capacity	2448:2473	the fertilization capacity of SP-treated ES	2448:2490	More comprehensive studies are required in order to evaluate the fertilization capacity of SP-treated ES in order to facilitate its application in dromedary camel assisted reproduction technology.
33774369	14	135	theme	assisted	2550:2557	arg1	technology					2572:2581	dromedary camel assisted reproduction technology	2534:2581	dromedary camel assisted reproduction technology	2534:2581	More comprehensive studies are required in order to evaluate the fertilization capacity of SP-treated ES in order to facilitate its application in dromedary camel assisted reproduction technology.
33774369	12	136	theme	GSA	2255:2257	arg1	I-B4					2259:2262	GSA I-B4	2255:2262	GSA I-B4	2255:2262	The cytoplasmic droplets of both control and seminal plasma-treated sperm bound Con A, PHA-E, PHA-L, RCA120, HPA, PNA, sWGA, GSA I-B4, and GSA II.
33774369	8	137	dep	lactosamine	1241:1251	arg1	PHA-L					1261:1265	PHA-L	1261:1265	PHA-L	1261:1265	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	8	137	dep	lactosamine	1241:1251	arg1	RCA120					1272:1277	RCA120	1272:1277	RCA120	1272:1277	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	8	137	dep	lactosamine	1241:1251	arg1	A					1258:1258	Con A	1254:1258	Con A	1254:1258	Lectin-binding analysis of the glycocalyx in control sperm revealed the presence of (1) N-glycans terminating with lactosamine (Con A, PHA-L, and RCA120), in both acrosomal and tail regions.
33774369	10	138	theme	GSA	1659:1661	arg1	residues					1669:1676	both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues	1592:1676	residues	1669:1676	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues was also noted in the acrosomal cap region of control sperm.
33774369	10	138	theme	GSA	1659:1661	arg1	I-B4					1663:1666	GSA I-B4	1659:1666	GSA I-B4	1659:1666	The expression of both N-acetylglucosamine (sWGA and GSA II) and terminalαgalactose (GSA I-B4) residues was also noted in the acrosomal cap region of control sperm.
33774369	14	139	theme	dromedary	2534:2542	arg1	technology					2572:2581	dromedary camel assisted reproduction technology	2534:2581	dromedary camel assisted reproduction technology	2534:2581	More comprehensive studies are required in order to evaluate the fertilization capacity of SP-treated ES in order to facilitate its application in dromedary camel assisted reproduction technology.
33774369	3	140	theme	SP	515:516	arg1	exposure					518:525	SP exposure	515:525	SP exposure	515:525	Since the sperm glycocalyx plays a key role in reproduction we aimed to evaluate whether SP exposure modifies the surface glycosylation patterns of cryopreserved dromedary ES.
33774369	14	141	theme	SP-treated	2478:2487	arg1	ES					2489:2490	SP-treated ES	2478:2490	SP-treated ES	2478:2490	More comprehensive studies are required in order to evaluate the fertilization capacity of SP-treated ES in order to facilitate its application in dromedary camel assisted reproduction technology.
34723499	3	0	with	hydrogel	590:597	arg1	loading					626:632	sufficient mechanical loading	604:632	sufficient mechanical loading	604:632	Here, a strategy that integrates hydrogels and nanomaterials is shown to form a HA hydrogel with sufficient mechanical loading for cartilage tissue production and recombination.
34723499	7	1	theme	defect	1465:1470	arg1	model					1472:1476	the full-thickness cartilage defect model	1436:1476	the full-thickness cartilage defect model of SD rats	1436:1487	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	1	2	from	biomaterials	173:184	arg1	field					193:197	the field	189:197	the field of cartilage tissue engineering (CTE)	189:235	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	1	3	theme	most	149:152	arg1	biomaterials					173:184	most functional natural biomaterials	149:184	most functional natural biomaterials in the field of cartilage tissue engineering (CTE)	149:235	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	7	4	theme	full-thickness	1440:1453	arg1	model					1472:1476	the full-thickness cartilage defect model	1436:1476	the full-thickness cartilage defect model of SD rats	1436:1487	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	6	5	with	hydrogels	1008:1016	arg1	modulus					1037:1043	a compressive modulus	1023:1043	a compressive modulus of 0.46 ± 0.05 MPa	1023:1062	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	7	6	theme	cartilage	1455:1463	arg1	model					1472:1476	the full-thickness cartilage defect model	1436:1476	the full-thickness cartilage defect model of SD rats	1436:1487	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	1	7	theme	functional	154:163	arg1	biomaterials					173:184	most functional natural biomaterials	149:184	most functional natural biomaterials in the field of cartilage tissue engineering (CTE)	149:235	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	5	8	theme	nanocomposite	961:973	arg1	hydrogels					975:983	HA/CNF nanocomposite hydrogels	954:983	HA/CNF nanocomposite hydrogels	954:983	In this study, we developed methacrylate-functionalized CNFs that are able to photo-crosslink with methacrylated HA to fabricate HA/CNF nanocomposite hydrogels.
34723499	2	9	theme	native	335:340	arg1	cartilage					342:350	the native cartilage	331:350	the native cartilage	331:350	Even with the promising advantages of HA hydrogels, the complicated mechanical properties of the native cartilage have not been realized, and fabricating HA hydrogels with excellent mechanical properties to make them practical in CTE still remains a current challenge.
34723499	2	10	theme	HA	276:277	arg1	hydrogels					279:287	HA hydrogels	276:287	HA hydrogels	276:287	Even with the promising advantages of HA hydrogels, the complicated mechanical properties of the native cartilage have not been realized, and fabricating HA hydrogels with excellent mechanical properties to make them practical in CTE still remains a current challenge.
34723499	6	11	theme	compressive	1025:1035	arg1	modulus					1037:1043	a compressive modulus	1023:1043	a compressive modulus of 0.46 ± 0.05 MPa	1023:1062	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	2	12	theme	complicated	294:304	arg1	properties					317:326	the complicated mechanical properties	290:326	the complicated mechanical properties of the native cartilage	290:350	Even with the promising advantages of HA hydrogels, the complicated mechanical properties of the native cartilage have not been realized, and fabricating HA hydrogels with excellent mechanical properties to make them practical in CTE still remains a current challenge.
34723499	8	13	theme	new	1561:1563	arg1	possibility					1565:1575	a new possibility	1559:1575	a new possibility for fabricating a scaffold in CTE	1559:1609	These results suggest that the HA/CNF nanocomposite hydrogel creates a new possibility for fabricating a scaffold in CTE.
34723499	2	14	theme	cartilage	342:350	arg1	properties					317:326	the complicated mechanical properties	290:326	the complicated mechanical properties of the native cartilage	290:350	Even with the promising advantages of HA hydrogels, the complicated mechanical properties of the native cartilage have not been realized, and fabricating HA hydrogels with excellent mechanical properties to make them practical in CTE still remains a current challenge.
34723499	5	15	theme	HA/CNF	954:959	arg1	hydrogels					975:983	HA/CNF nanocomposite hydrogels	954:983	HA/CNF nanocomposite hydrogels	954:983	In this study, we developed methacrylate-functionalized CNFs that are able to photo-crosslink with methacrylated HA to fabricate HA/CNF nanocomposite hydrogels.
34723499	4	16	theme	Cellulose	685:693	arg1	candidates					741:750	promising nanomaterial candidates	718:750	promising nanomaterial candidates	718:750	Cellulose nanofibrils (CNFs) are promising nanomaterial candidates as they possess high mechanical strength and excellent biocompatibility.
34723499	4	16	theme	Cellulose	685:693	arg1	CNFs					708:711	CNFs	708:711	CNFs	708:711	Cellulose nanofibrils (CNFs) are promising nanomaterial candidates as they possess high mechanical strength and excellent biocompatibility.
34723499	4	16	theme	Cellulose	685:693	arg1	nanofibrils					695:705	Cellulose nanofibrils	685:705	Cellulose nanofibrils (CNFs)	685:712	Cellulose nanofibrils (CNFs) are promising nanomaterial candidates as they possess high mechanical strength and excellent biocompatibility.
34723499	4	17	theme	nanomaterial	728:739	arg1	candidates					741:750	promising nanomaterial candidates	718:750	promising nanomaterial candidates	718:750	Cellulose nanofibrils (CNFs) are promising nanomaterial candidates as they possess high mechanical strength and excellent biocompatibility.
34723499	4	17	theme	nanomaterial	728:739	arg1	nanofibrils					695:705	Cellulose nanofibrils	685:705	Cellulose nanofibrils (CNFs)	685:712	Cellulose nanofibrils (CNFs) are promising nanomaterial candidates as they possess high mechanical strength and excellent biocompatibility.
34723499	4	18	theme	mechanical	773:782	arg1	strength					784:791	high mechanical strength	768:791	high mechanical strength	768:791	Cellulose nanofibrils (CNFs) are promising nanomaterial candidates as they possess high mechanical strength and excellent biocompatibility.
34723499	1	19	theme	natural	165:171	arg1	biomaterials					173:184	most functional natural biomaterials	149:184	most functional natural biomaterials in the field of cartilage tissue engineering (CTE)	149:235	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	2	20	theme	current	488:494	arg1	challenge					496:504	a current challenge	486:504	a current challenge	486:504	Even with the promising advantages of HA hydrogels, the complicated mechanical properties of the native cartilage have not been realized, and fabricating HA hydrogels with excellent mechanical properties to make them practical in CTE still remains a current challenge.
34723499	5	21	theme	methacrylated	924:936	arg1	HA					938:939	methacrylated HA	924:939	methacrylated HA	924:939	In this study, we developed methacrylate-functionalized CNFs that are able to photo-crosslink with methacrylated HA to fabricate HA/CNF nanocomposite hydrogels.
34723499	7	22	theme	cell	1336:1339	arg1	proliferation					1341:1353	mesenchymal stem cell proliferation	1319:1353	mesenchymal stem cell proliferation	1319:1353	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	2	23	theme	promising	252:260	arg1	advantages					262:271	the promising advantages	248:271	the promising advantages of HA hydrogels	248:287	Even with the promising advantages of HA hydrogels, the complicated mechanical properties of the native cartilage have not been realized, and fabricating HA hydrogels with excellent mechanical properties to make them practical in CTE still remains a current challenge.
34723499	7	24	theme	rats	1484:1487	arg1	model					1472:1476	the full-thickness cartilage defect model	1436:1476	the full-thickness cartilage defect model of SD rats	1436:1487	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	1	25	theme	biomaterials	173:184	arg1	biomaterials					173:184	most functional natural biomaterials	149:184	most functional natural biomaterials in the field of cartilage tissue engineering (CTE)	149:235	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	1	25	theme	biomaterials	173:184	arg1	one					142:144	one	142:144	one	142:144	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	2	26	with	hydrogels	395:403	arg1	properties					431:440	excellent mechanical properties	410:440	excellent mechanical properties	410:440	Even with the promising advantages of HA hydrogels, the complicated mechanical properties of the native cartilage have not been realized, and fabricating HA hydrogels with excellent mechanical properties to make them practical in CTE still remains a current challenge.
34723499	1	27	theme	Hyaluronic	101:110	arg1	acid					112:115	Hyaluronic acid	101:115	Hyaluronic acid (HA) based hydrogels	101:136	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	1	27	theme	Hyaluronic	101:110	arg1	HA					118:119	HA	118:119	HA	118:119	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	6	28	theme	0.198	1102:1106	arg1	MPa					1116:1118	0.198 ± 0.009 MPa	1102:1118	0.198 ± 0.009 MPa	1102:1118	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	6	28	theme	0.198	1102:1106	arg1	strength					1092:1099	adequate compressive strength	1071:1099	adequate compressive strength (0.198 ± 0.009 MPa)	1071:1119	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	7	29	theme	bone	1307:1310	arg1	marrow					1312:1317	bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation,	1307:1395	bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation,	1307:1395	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	1	30	theme	acid	112:115	arg1	hydrogels					128:136	Hyaluronic acid (HA) based hydrogels	101:136	Hyaluronic acid (HA) based hydrogels	101:136	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	8	31	from	scaffold	1595:1602	arg1	CTE					1607:1609	CTE	1607:1609	CTE	1607:1609	These results suggest that the HA/CNF nanocomposite hydrogel creates a new possibility for fabricating a scaffold in CTE.
34723499	2	32	theme	mechanical	420:429	arg1	properties					431:440	excellent mechanical properties	410:440	excellent mechanical properties	410:440	Even with the promising advantages of HA hydrogels, the complicated mechanical properties of the native cartilage have not been realized, and fabricating HA hydrogels with excellent mechanical properties to make them practical in CTE still remains a current challenge.
34723499	4	33	theme	promising	718:726	arg1	candidates					741:750	promising nanomaterial candidates	718:750	promising nanomaterial candidates	718:750	Cellulose nanofibrils (CNFs) are promising nanomaterial candidates as they possess high mechanical strength and excellent biocompatibility.
34723499	4	33	theme	promising	718:726	arg1	nanofibrils					695:705	Cellulose nanofibrils	685:705	Cellulose nanofibrils (CNFs)	685:712	Cellulose nanofibrils (CNFs) are promising nanomaterial candidates as they possess high mechanical strength and excellent biocompatibility.
34723499	7	34	theme	chondrogenic	1367:1378	arg1	differentiation					1380:1394	chondrogenic differentiation	1367:1394	chondrogenic differentiation	1367:1394	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	6	35	theme	adequate	1071:1078	arg1	MPa					1116:1118	0.198 ± 0.009 MPa	1102:1118	0.198 ± 0.009 MPa	1102:1118	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	6	35	theme	adequate	1071:1078	arg1	strength					1092:1099	adequate compressive strength	1071:1099	adequate compressive strength (0.198 ± 0.009 MPa)	1071:1119	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	7	36	theme	prominent	1409:1417	arg1	effect					1426:1431	prominent repair effect	1409:1431	prominent repair effect	1409:1431	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	7	37	theme	stem	1331:1334	arg1	proliferation					1341:1353	mesenchymal stem cell proliferation	1319:1353	mesenchymal stem cell proliferation	1319:1353	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	2	38	theme	excellent	410:418	arg1	properties					431:440	excellent mechanical properties	410:440	excellent mechanical properties	410:440	Even with the promising advantages of HA hydrogels, the complicated mechanical properties of the native cartilage have not been realized, and fabricating HA hydrogels with excellent mechanical properties to make them practical in CTE still remains a current challenge.
34723499	6	39	theme	composite	998:1006	arg1	hydrogels					1008:1016	The present composite hydrogels	986:1016	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa	986:1062	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	6	40	theme	stress-bearing	1177:1190	arg1	tissue					1192:1197	a stress-bearing tissue	1175:1197	a stress-bearing tissue such as articular cartilage	1175:1225	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	2	41	theme	hydrogels	279:287	arg1	advantages					262:271	the promising advantages	248:271	the promising advantages of HA hydrogels	248:287	Even with the promising advantages of HA hydrogels, the complicated mechanical properties of the native cartilage have not been realized, and fabricating HA hydrogels with excellent mechanical properties to make them practical in CTE still remains a current challenge.
34723499	6	42	theme	compressive	1080:1090	arg1	MPa					1116:1118	0.198 ± 0.009 MPa	1102:1118	0.198 ± 0.009 MPa	1102:1118	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	6	42	theme	compressive	1080:1090	arg1	strength					1092:1099	adequate compressive strength	1071:1099	adequate compressive strength (0.198 ± 0.009 MPa)	1071:1119	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	0	43	theme	Hyaluronic	48:57	arg1	Hydrogel					64:71	Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel	16:71	Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel for Cartilage Regeneration	16:98	In Situ Forming Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel for Cartilage Regeneration.
34723499	6	44	theme	present	990:996	arg1	hydrogels					1008:1016	The present composite hydrogels	986:1016	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa	986:1062	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	2	45	theme	HA	392:393	arg1	hydrogels					395:403	HA hydrogels	392:403	HA hydrogels with excellent mechanical properties to make them practical in CTE still remains a current challenge	392:504	Even with the promising advantages of HA hydrogels, the complicated mechanical properties of the native cartilage have not been realized, and fabricating HA hydrogels with excellent mechanical properties to make them practical in CTE still remains a current challenge.
34723499	4	46	theme	excellent	797:805	arg1	biocompatibility					807:822	excellent biocompatibility	797:822	excellent biocompatibility	797:822	Cellulose nanofibrils (CNFs) are promising nanomaterial candidates as they possess high mechanical strength and excellent biocompatibility.
34723499	7	47	theme	mesenchymal	1319:1329	arg1	proliferation					1341:1353	mesenchymal stem cell proliferation	1319:1353	mesenchymal stem cell proliferation	1319:1353	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	1	48	theme	cartilage	202:210	arg1	CTE					232:234	CTE	232:234	CTE	232:234	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	1	48	theme	cartilage	202:210	arg1	engineering					219:229	cartilage tissue engineering	202:229	cartilage tissue engineering (CTE)	202:235	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	0	49	theme	Nanofibril-Reinforced	26:46	arg1	Hydrogel					64:71	Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel	16:71	Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel for Cartilage Regeneration	16:98	In Situ Forming Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel for Cartilage Regeneration.
34723499	3	50	theme	sufficient	604:613	arg1	loading					626:632	sufficient mechanical loading	604:632	sufficient mechanical loading	604:632	Here, a strategy that integrates hydrogels and nanomaterials is shown to form a HA hydrogel with sufficient mechanical loading for cartilage tissue production and recombination.
34723499	0	51	theme	Cellulose	16:24	arg1	Hydrogel					64:71	Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel	16:71	Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel for Cartilage Regeneration	16:98	In Situ Forming Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel for Cartilage Regeneration.
34723499	5	52	theme	methacrylate-functionalized	853:879	arg1	CNFs					881:884	methacrylate-functionalized CNFs	853:884	methacrylate-functionalized CNFs that are able to photo-crosslink with methacrylated HA to fabricate HA/CNF nanocomposite hydrogels	853:983	In this study, we developed methacrylate-functionalized CNFs that are able to photo-crosslink with methacrylated HA to fabricate HA/CNF nanocomposite hydrogels.
34723499	1	53	theme	tissue	212:217	arg1	CTE					232:234	CTE	232:234	CTE	232:234	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	1	53	theme	tissue	212:217	arg1	engineering					219:229	cartilage tissue engineering	202:229	cartilage tissue engineering (CTE)	202:235	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	3	54	theme	mechanical	615:624	arg1	loading					626:632	sufficient mechanical loading	604:632	sufficient mechanical loading	604:632	Here, a strategy that integrates hydrogels and nanomaterials is shown to form a HA hydrogel with sufficient mechanical loading for cartilage tissue production and recombination.
34723499	8	55	theme	HA/CNF	1521:1526	arg1	hydrogel					1542:1549	the HA/CNF nanocomposite hydrogel	1517:1549	the HA/CNF nanocomposite hydrogel	1517:1549	These results suggest that the HA/CNF nanocomposite hydrogel creates a new possibility for fabricating a scaffold in CTE.
34723499	7	56	theme	SD	1481:1482	arg1	rats					1484:1487	SD rats	1481:1487	SD rats	1481:1487	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	0	57	theme	Acid	59:62	arg1	Hydrogel					64:71	Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel	16:71	Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel for Cartilage Regeneration	16:98	In Situ Forming Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel for Cartilage Regeneration.
34723499	1	58	theme	based	122:126	arg1	hydrogels					128:136	Hyaluronic acid (HA) based hydrogels	101:136	Hyaluronic acid (HA) based hydrogels	101:136	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	4	59	contain	possess	760:766	arg2	strength					784:791	high mechanical strength	768:791	high mechanical strength	768:791	Cellulose nanofibrils (CNFs) are promising nanomaterial candidates as they possess high mechanical strength and excellent biocompatibility.
34723499	4	59	contain	possess	760:766	arg2	biocompatibility					807:822	excellent biocompatibility	797:822	excellent biocompatibility	797:822	Cellulose nanofibrils (CNFs) are promising nanomaterial candidates as they possess high mechanical strength and excellent biocompatibility.
34723499	4	59	contain	possess	760:766	arg1	they					755:758	they	755:758	they	755:758	Cellulose nanofibrils (CNFs) are promising nanomaterial candidates as they possess high mechanical strength and excellent biocompatibility.
34723499	7	60	dep	marrow	1312:1317	arg1	differentiation					1380:1394	chondrogenic differentiation	1367:1394	chondrogenic differentiation	1367:1394	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	7	60	dep	marrow	1312:1317	arg1	proliferation					1341:1353	mesenchymal stem cell proliferation	1319:1353	mesenchymal stem cell proliferation	1319:1353	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	7	61	theme	repair	1419:1424	arg1	effect					1426:1431	prominent repair effect	1409:1431	prominent repair effect	1409:1431	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	7	62	theme	good	1281:1284	arg1	microenvironment					1286:1301	a good microenvironment	1279:1301	a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation,	1279:1395	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	1	63	theme	engineering	219:229	arg1	field					193:197	the field	189:197	the field of cartilage tissue engineering (CTE)	189:235	Hyaluronic acid (HA) based hydrogels are one of most functional natural biomaterials in the field of cartilage tissue engineering (CTE).
34723499	4	64	theme	high	768:771	arg1	strength					784:791	high mechanical strength	768:791	high mechanical strength	768:791	Cellulose nanofibrils (CNFs) are promising nanomaterial candidates as they possess high mechanical strength and excellent biocompatibility.
34723499	3	65	theme	cartilage	638:646	arg1	production					655:664	cartilage tissue production	638:664	cartilage tissue production	638:664	Here, a strategy that integrates hydrogels and nanomaterials is shown to form a HA hydrogel with sufficient mechanical loading for cartilage tissue production and recombination.
34723499	2	66	theme	mechanical	306:315	arg1	properties					317:326	the complicated mechanical properties	290:326	the complicated mechanical properties of the native cartilage	290:350	Even with the promising advantages of HA hydrogels, the complicated mechanical properties of the native cartilage have not been realized, and fabricating HA hydrogels with excellent mechanical properties to make them practical in CTE still remains a current challenge.
34723499	6	67	theme	0.05	1055:1058	arg1	±					1053:1053	±	1053:1053	±	1053:1053	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	0	68	theme	Cartilage	77:85	arg1	Regeneration					87:98	Cartilage Regeneration	77:98	Cartilage Regeneration	77:98	In Situ Forming Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel for Cartilage Regeneration.
34723499	3	69	theme	tissue	648:653	arg1	production					655:664	cartilage tissue production	638:664	cartilage tissue production	638:664	Here, a strategy that integrates hydrogels and nanomaterials is shown to form a HA hydrogel with sufficient mechanical loading for cartilage tissue production and recombination.
34723499	6	70	theme	articular	1207:1215	arg1	cartilage					1217:1225	articular cartilage	1207:1225	articular cartilage	1207:1225	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	6	71	theme	±	1108:1108	arg1	MPa					1116:1118	0.198 ± 0.009 MPa	1102:1118	0.198 ± 0.009 MPa	1102:1118	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	6	71	theme	±	1108:1108	arg1	strength					1092:1099	adequate compressive strength	1071:1099	adequate compressive strength (0.198 ± 0.009 MPa)	1071:1119	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	7	72	theme	nanocomposite	1242:1254	arg1	hydrogel					1256:1263	this nanocomposite hydrogel	1237:1263	this nanocomposite hydrogel	1237:1263	Besides, this nanocomposite hydrogel could provide a good microenvironment for bone marrow mesenchymal stem cell proliferation, as well as chondrogenic differentiation, and exhibit prominent repair effect in the full-thickness cartilage defect model of SD rats.
34723499	8	73	theme	nanocomposite	1528:1540	arg1	hydrogel					1542:1549	the HA/CNF nanocomposite hydrogel	1517:1549	the HA/CNF nanocomposite hydrogel	1517:1549	These results suggest that the HA/CNF nanocomposite hydrogel creates a new possibility for fabricating a scaffold in CTE.
34723499	3	74	theme	HA	587:588	arg1	hydrogel					590:597	a HA hydrogel	585:597	a HA hydrogel with sufficient mechanical loading for cartilage tissue production and recombination	585:682	Here, a strategy that integrates hydrogels and nanomaterials is shown to form a HA hydrogel with sufficient mechanical loading for cartilage tissue production and recombination.
34723499	6	75	theme	MPa	1060:1062	arg1	modulus					1037:1043	a compressive modulus	1023:1043	a compressive modulus of 0.46 ± 0.05 MPa	1023:1062	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
34723499	6	76	theme	0.46	1048:1051	arg1	±					1053:1053	±	1053:1053	±	1053:1053	The present composite hydrogels with a compressive modulus of 0.46 ± 0.05 MPa showed adequate compressive strength (0.198 ± 0.009 MPa) and restorability, which can be expected to employ as a stress-bearing tissue such as articular cartilage.
32144516	0	0	theme	miehei	85:90	arg1	response					42:49	adaptive response	33:49	adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks	33:128	Osmolytes and membrane lipids in adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks.
32144516	4	1	theme	lipids	854:859	arg1	degree					838:843	the unsaturation degree	821:843	the unsaturation degree of polar lipids	821:859	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	1	2	from	thermophiles	256:267	arg1	predominant					291:301	predominant	291:301	predominant	291:301	In contrast to mesophiles, in which levels of trehalose and phosphatidic acids (PA) increased only under heat shock (HS), in thermophiles trehalose and PA were predominant under optimal growth conditions.
32144516	4	3	theme	ergosterol	998:1007	arg1	proportion					1009:1018	ergosterol proportion	998:1018	ergosterol proportion	998:1018	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	4	theme	total	910:914	arg1	OS					920:921	total St. OS	910:921	total St. OS	910:921	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	5	5	theme	low	1037:1039	arg1	ability					1041:1047	the low ability	1033:1047	the low ability of Mucorales to produce polyols	1033:1079	Despite the low ability of Mucorales to produce polyols, increase in the level of arabitol and glycerol was observed under OS.
32144516	0	6	theme	Rhizomucor	74:83	arg1	miehei					85:90	thermophilic fungus Rhizomucor miehei	54:90	thermophilic fungus Rhizomucor miehei	54:90	Osmolytes and membrane lipids in adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks.
32144516	4	7	theme	PA	747:748	arg1	proportion					750:759	the PA proportion	743:759	the PA proportion with simultaneous decrease of sterols (St)	743:802	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	2	8	theme	oxidative	574:582	arg1	shocks					590:595	oxidative (OxS) shocks	574:595	oxidative (OxS) shocks	574:595	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	0	9	theme	cold	95:98	arg1	shocks					123:128	cold, osmotic and oxidative shocks	95:128	cold, osmotic and oxidative shocks	95:128	Osmolytes and membrane lipids in adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks.
32144516	0	10	from	Osmolytes	0:8	arg1	response					42:49	adaptive response	33:49	adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks	33:128	Osmolytes and membrane lipids in adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks.
32144516	4	11	theme	simultaneous	766:777	arg1	decrease					779:786	simultaneous decrease	766:786	simultaneous decrease of sterols (St)	766:802	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	12	theme	polar	848:852	arg1	lipids					854:859	polar lipids	848:859	polar lipids	848:859	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	2	13	theme	membrane	467:474	arg1	lipids					476:481	membrane lipids	467:481	membrane lipids	467:481	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	6	14	contain	had	1199:1201	arg1	OxS					1152:1154	OxS	1152:1154	OxS	1152:1154	OxS led to the decrease of trehalose level and had no effect on the lipid composition.
32144516	6	14	contain	had	1199:1201	arg2	effect					1206:1211	no effect	1203:1211	no effect	1203:1211	OxS led to the decrease of trehalose level and had no effect on the lipid composition.
32144516	1	15	theme	heat	236:239	arg1	HS					248:249	HS	248:249	HS	248:249	In contrast to mesophiles, in which levels of trehalose and phosphatidic acids (PA) increased only under heat shock (HS), in thermophiles trehalose and PA were predominant under optimal growth conditions.
32144516	1	15	theme	heat	236:239	arg1	shock					241:245	heat shock	236:245	heat shock (HS)	236:250	In contrast to mesophiles, in which levels of trehalose and phosphatidic acids (PA) increased only under heat shock (HS), in thermophiles trehalose and PA were predominant under optimal growth conditions.
32144516	0	16	theme	osmotic	101:107	arg1	shocks					123:128	cold, osmotic and oxidative shocks	95:128	cold, osmotic and oxidative shocks	95:128	Osmolytes and membrane lipids in adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks.
32144516	1	17	theme	optimal	309:315	arg1	conditions					324:333	optimal growth conditions	309:333	optimal growth conditions	309:333	In contrast to mesophiles, in which levels of trehalose and phosphatidic acids (PA) increased only under heat shock (HS), in thermophiles trehalose and PA were predominant under optimal growth conditions.
32144516	2	18	theme	trehalose	357:365	arg1	protection					367:376	trehalose protection	357:376	trehalose protection	357:376	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	5	19	from	increase	1082:1089	arg1	level					1098:1102	the level	1094:1102	the level of arabitol and glycerol	1094:1127	Despite the low ability of Mucorales to produce polyols, increase in the level of arabitol and glycerol was observed under OS.
32144516	2	20	theme	osmolytes	453:461	arg1	composition					438:448	the composition	434:448	the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei	434:526	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	1	21	theme	growth	317:322	arg1	conditions					324:333	optimal growth conditions	309:333	optimal growth conditions	309:333	In contrast to mesophiles, in which levels of trehalose and phosphatidic acids (PA) increased only under heat shock (HS), in thermophiles trehalose and PA were predominant under optimal growth conditions.
32144516	6	22	theme	lipid	1220:1224	arg1	composition					1226:1236	the lipid composition	1216:1236	the lipid composition	1216:1236	OxS led to the decrease of trehalose level and had no effect on the lipid composition.
32144516	4	23	dep	sterols	791:797	arg1	St					800:801	St	800:801	St	800:801	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	5	24	theme	Mucorales	1052:1060	arg1	ability					1041:1047	the low ability	1033:1047	the low ability of Mucorales to produce polyols	1033:1079	Despite the low ability of Mucorales to produce polyols, increase in the level of arabitol and glycerol was observed under OS.
32144516	4	25	theme	unsaturation	825:836	arg1	degree					838:843	the unsaturation degree	821:843	the unsaturation degree of polar lipids	821:859	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	26	theme	ergosterol	885:894	arg1	proportion					896:905	the ergosterol proportion	881:905	the ergosterol proportion in total St. OS	881:921	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	27	theme	sterols	791:797	arg1	decrease					779:786	simultaneous decrease	766:786	simultaneous decrease of sterols (St)	766:802	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	3	28	theme	glycerol	632:639	arg1	accumulation					616:627	no accumulation	613:627	no accumulation of glycerol in the mycelium	613:655	CS resulted in no accumulation of glycerol in the mycelium, while the amount of trehalose decreased.
32144516	3	29	from	accumulation	616:627	arg1	mycelium					648:655	the mycelium	644:655	the mycelium	644:655	CS resulted in no accumulation of glycerol in the mycelium, while the amount of trehalose decreased.
32144516	2	30	theme	OxS	585:587	arg1	shocks					590:595	oxidative (OxS) shocks	574:595	oxidative (OxS) shocks	574:595	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	1	31	dep	mesophiles	146:155	arg1	contrast					134:141	contrast	134:141	contrast	134:141	In contrast to mesophiles, in which levels of trehalose and phosphatidic acids (PA) increased only under heat shock (HS), in thermophiles trehalose and PA were predominant under optimal growth conditions.
32144516	4	32	theme	lipid	952:956	arg1	composition					958:968	the lipid composition	948:968	the lipid composition	948:968	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	33	from	proportion	896:905	arg1	OS					920:921	total St. OS	910:921	total St. OS	910:921	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	0	34	theme	oxidative	113:121	arg1	shocks					123:128	cold, osmotic and oxidative shocks	95:128	cold, osmotic and oxidative shocks	95:128	Osmolytes and membrane lipids in adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks.
32144516	6	35	theme	level	1189:1193	arg1	decrease					1167:1174	the decrease	1163:1174	the decrease of trehalose level	1163:1193	OxS led to the decrease of trehalose level and had no effect on the lipid composition.
32144516	7	36	theme	mesophiles	1364:1373	arg1	mechanisms					1333:1342	adaptation mechanisms	1322:1342	adaptation mechanisms of thermophiles and mesophiles	1322:1373	Thus, our results show the similarity (OS) and the difference (CS and OxS) between adaptation mechanisms of thermophiles and mesophiles.
32144516	2	37	theme	protection	367:376	arg1	role					349:352	the role	345:352	the role of trehalose protection in the adaptation of thermophiles to various stressors	345:431	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	0	38	theme	membrane	14:21	arg1	lipids					23:28	membrane lipids	14:28	membrane lipids	14:28	Osmolytes and membrane lipids in adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks.
32144516	2	39	theme	thermophilic	490:501	arg1	miehei					521:526	the thermophilic fungus Rhizomucor miehei	486:526	the thermophilic fungus Rhizomucor miehei	486:526	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	1	40	theme	trehalose	177:185	arg1	levels					167:172	levels	167:172	levels of trehalose and phosphatidic acids (PA)	167:213	In contrast to mesophiles, in which levels of trehalose and phosphatidic acids (PA) increased only under heat shock (HS), in thermophiles trehalose and PA were predominant under optimal growth conditions.
32144516	0	41	theme	adaptive	33:40	arg1	response					42:49	adaptive response	33:49	adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks	33:128	Osmolytes and membrane lipids in adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks.
32144516	4	42	theme	lipid	708:712	arg1	changes					714:720	The main lipid changes	699:720	The main lipid changes	699:720	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	42	theme	lipid	708:712	arg1	increase					731:738	the increase	727:738	the increase in the PA proportion with simultaneous decrease of sterols (St)	727:802	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	1	43	from	predominant	291:301	arg1	thermophiles					256:267	thermophiles	256:267	thermophiles	256:267	In contrast to mesophiles, in which levels of trehalose and phosphatidic acids (PA) increased only under heat shock (HS), in thermophiles trehalose and PA were predominant under optimal growth conditions.
32144516	2	44	theme	various	415:421	arg1	stressors					423:431	various stressors	415:431	various stressors	415:431	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	4	45	theme	main	703:706	arg1	changes					714:720	The main lipid changes	699:720	The main lipid changes	699:720	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	45	theme	main	703:706	arg1	increase					731:738	the increase	727:738	the increase in the PA proportion with simultaneous decrease of sterols (St)	727:802	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	1	46	theme	phosphatidic	191:202	arg1	acids					204:208	phosphatidic acids	191:208	phosphatidic acids	191:208	In contrast to mesophiles, in which levels of trehalose and phosphatidic acids (PA) increased only under heat shock (HS), in thermophiles trehalose and PA were predominant under optimal growth conditions.
32144516	2	47	theme	lipids	476:481	arg1	composition					438:448	the composition	434:448	the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei	434:526	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	6	48	theme	trehalose	1179:1187	arg1	level					1189:1193	trehalose level	1179:1193	trehalose level	1179:1193	OxS led to the decrease of trehalose level and had no effect on the lipid composition.
32144516	2	49	from	composition	438:448	arg1	miehei					521:526	the thermophilic fungus Rhizomucor miehei	486:526	the thermophilic fungus Rhizomucor miehei	486:526	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	4	50	from	increase	731:738	arg1	OS					920:921	total St. OS	910:921	total St. OS	910:921	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	50	from	increase	731:738	arg1	proportion					750:759	the PA proportion	743:759	the PA proportion with simultaneous decrease of sterols (St)	743:802	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	2	51	theme	thermophiles	399:410	arg1	adaptation					385:394	the adaptation	381:394	the adaptation of thermophiles to various stressors	381:431	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	2	52	theme	fungus	503:508	arg1	miehei					521:526	the thermophilic fungus Rhizomucor miehei	486:526	the thermophilic fungus Rhizomucor miehei	486:526	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	4	53	from	increase	809:816	arg1	OS					920:921	total St. OS	910:921	total St. OS	910:921	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	53	from	increase	809:816	arg1	proportion					750:759	the PA proportion	743:759	the PA proportion with simultaneous decrease of sterols (St)	743:802	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	54	theme	degree	838:843	arg1	decrease					869:876	the decrease	865:876	the decrease of the ergosterol proportion in total St. OS	865:921	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	54	theme	degree	838:843	arg1	increase					809:816	the increase	805:816	the increase of the unsaturation degree of polar lipids	805:859	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	54	theme	degree	838:843	arg1	changes					714:720	The main lipid changes	699:720	The main lipid changes	699:720	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	54	theme	degree	838:843	arg1	increase					731:738	the increase	727:738	the increase in the PA proportion with simultaneous decrease of sterols (St)	727:802	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	55	from	changes	937:943	arg1	composition					958:968	the lipid composition	948:968	the lipid composition	948:968	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	7	56	dep	difference	1290:1299	arg1	OxS					1309:1311	OxS	1309:1311	OxS	1309:1311	Thus, our results show the similarity (OS) and the difference (CS and OxS) between adaptation mechanisms of thermophiles and mesophiles.
32144516	7	56	dep	difference	1290:1299	arg1	CS					1302:1303	CS	1302:1303	CS	1302:1303	Thus, our results show the similarity (OS) and the difference (CS and OxS) between adaptation mechanisms of thermophiles and mesophiles.
32144516	1	57	attach	predominant	291:301	arg2	trehalose					269:277	trehalose	269:277	trehalose	269:277	In contrast to mesophiles, in which levels of trehalose and phosphatidic acids (PA) increased only under heat shock (HS), in thermophiles trehalose and PA were predominant under optimal growth conditions.
32144516	1	57	attach	predominant	291:301	arg1	thermophiles					256:267	thermophiles	256:267	thermophiles	256:267	In contrast to mesophiles, in which levels of trehalose and phosphatidic acids (PA) increased only under heat shock (HS), in thermophiles trehalose and PA were predominant under optimal growth conditions.
32144516	1	57	attach	predominant	291:301	arg2	PA					283:284	PA	283:284	PA	283:284	In contrast to mesophiles, in which levels of trehalose and phosphatidic acids (PA) increased only under heat shock (HS), in thermophiles trehalose and PA were predominant under optimal growth conditions.
32144516	5	58	theme	arabitol	1107:1114	arg1	level					1098:1102	the level	1094:1102	the level of arabitol and glycerol	1094:1127	Despite the low ability of Mucorales to produce polyols, increase in the level of arabitol and glycerol was observed under OS.
32144516	1	59	theme	acids	204:208	arg1	levels					167:172	levels	167:172	levels of trehalose and phosphatidic acids (PA)	167:213	In contrast to mesophiles, in which levels of trehalose and phosphatidic acids (PA) increased only under heat shock (HS), in thermophiles trehalose and PA were predominant under optimal growth conditions.
32144516	2	60	theme	Rhizomucor	510:519	arg1	miehei					521:526	the thermophilic fungus Rhizomucor miehei	486:526	the thermophilic fungus Rhizomucor miehei	486:526	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	4	61	with	proportion	750:759	arg1	decrease					779:786	simultaneous decrease	766:786	simultaneous decrease of sterols (St)	766:802	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	7	62	theme	thermophiles	1347:1358	arg1	mechanisms					1333:1342	adaptation mechanisms	1322:1342	adaptation mechanisms of thermophiles and mesophiles	1322:1373	Thus, our results show the similarity (OS) and the difference (CS and OxS) between adaptation mechanisms of thermophiles and mesophiles.
32144516	0	63	theme	fungus	67:72	arg1	miehei					85:90	thermophilic fungus Rhizomucor miehei	54:90	thermophilic fungus Rhizomucor miehei	54:90	Osmolytes and membrane lipids in adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks.
32144516	7	64	theme	adaptation	1322:1331	arg1	mechanisms					1333:1342	adaptation mechanisms	1322:1342	adaptation mechanisms of thermophiles and mesophiles	1322:1373	Thus, our results show the similarity (OS) and the difference (CS and OxS) between adaptation mechanisms of thermophiles and mesophiles.
32144516	2	65	from	role	349:352	arg1	adaptation					385:394	the adaptation	381:394	the adaptation of thermophiles to various stressors	381:431	To study the role of trehalose protection in the adaptation of thermophiles to various stressors, the composition of osmolytes and membrane lipids in the thermophilic fungus Rhizomucor miehei was studied under cold (CS), osmotic (OS) and oxidative (OxS) shocks.
32144516	5	66	theme	glycerol	1120:1127	arg1	level					1098:1102	the level	1094:1102	the level of arabitol and glycerol	1094:1127	Despite the low ability of Mucorales to produce polyols, increase in the level of arabitol and glycerol was observed under OS.
32144516	3	67	theme	trehalose	678:686	arg1	trehalose					678:686	trehalose	678:686	trehalose	678:686	CS resulted in no accumulation of glycerol in the mycelium, while the amount of trehalose decreased.
32144516	3	67	theme	trehalose	678:686	arg1	amount					668:673	the amount	664:673	the amount of trehalose	664:686	CS resulted in no accumulation of glycerol in the mycelium, while the amount of trehalose decreased.
32144516	0	68	theme	thermophilic	54:65	arg1	miehei					85:90	thermophilic fungus Rhizomucor miehei	54:90	thermophilic fungus Rhizomucor miehei	54:90	Osmolytes and membrane lipids in adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks.
32144516	0	69	from	lipids	23:28	arg1	response					42:49	adaptive response	33:49	adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks	33:128	Osmolytes and membrane lipids in adaptive response of thermophilic fungus Rhizomucor miehei to cold, osmotic and oxidative shocks.
32144516	4	70	theme	proportion	896:905	arg1	decrease					869:876	the decrease	865:876	the decrease of the ergosterol proportion in total St. OS	865:921	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	70	theme	proportion	896:905	arg1	increase					809:816	the increase	805:816	the increase of the unsaturation degree of polar lipids	805:859	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	70	theme	proportion	896:905	arg1	changes					714:720	The main lipid changes	699:720	The main lipid changes	699:720	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	70	theme	proportion	896:905	arg1	increase					731:738	the increase	727:738	the increase in the PA proportion with simultaneous decrease of sterols (St)	727:802	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	71	theme	proportion	1009:1018	arg1	decrease					986:993	the decrease	982:993	the decrease of ergosterol proportion	982:1018	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	72	from	OS	920:921	arg1	decrease					869:876	the decrease	865:876	the decrease of the ergosterol proportion in total St. OS	865:921	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	72	from	OS	920:921	arg1	increase					809:816	the increase	805:816	the increase of the unsaturation degree of polar lipids	805:859	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	72	from	OS	920:921	arg1	changes					714:720	The main lipid changes	699:720	The main lipid changes	699:720	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	72	from	OS	920:921	arg1	increase					731:738	the increase	727:738	the increase in the PA proportion with simultaneous decrease of sterols (St)	727:802	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	73	theme	St.	916:918	arg1	OS					920:921	total St. OS	910:921	total St. OS	910:921	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	74	from	decrease	869:876	arg1	OS					920:921	total St. OS	910:921	total St. OS	910:921	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32144516	4	74	from	decrease	869:876	arg1	proportion					750:759	the PA proportion	743:759	the PA proportion with simultaneous decrease of sterols (St)	743:802	The main lipid changes were the increase in the PA proportion with simultaneous decrease of sterols (St), the increase of the unsaturation degree of polar lipids and the decrease of the ergosterol proportion in total St. OS did not cause changes in the lipid composition, but led to the decrease of ergosterol proportion too.
32444475	10	0	theme	responsible	1770:1780	arg1	outbreaks					1801:1809	responsible for food poisoning outbreaks	1770:1809	responsible for food poisoning outbreaks related to various foods in developing countries	1770:1858	flexneri is a widespread foodborne pathogen causing food contamination and responsible for food poisoning outbreaks related to various foods in developing countries.
32444475	2	1	theme	serious	307:313	arg1	threats					315:321	serious threats	307:321	serious threats to food safety and human health	307:353	Biofilm formation by S. flexneri can cause the emergence of antibiotic-resistant strains, which poses serious threats to food safety and human health.
32444475	7	2	theme	L-EPS	1482:1486	arg1	2-1					1488:1490	the acidic polysaccharide L-EPS 2-1	1456:1490	the acidic polysaccharide L-EPS 2-1	1456:1490	L-EPS was separated into the neutral polysaccharide L-EPS 1-1 and the acidic polysaccharide L-EPS 2-1 by ion-exchange chromatography and gel chromatography.
32444475	7	3	theme	polysaccharide	1427:1440	arg1	1-1					1448:1450	the neutral polysaccharide L-EPS 1-1	1415:1450	the neutral polysaccharide L-EPS 1-1	1415:1450	L-EPS was separated into the neutral polysaccharide L-EPS 1-1 and the acidic polysaccharide L-EPS 2-1 by ion-exchange chromatography and gel chromatography.
32444475	14	4	theme	potential	2384:2392	arg1	ability					2394:2400	the potential ability	2380:2400	the potential ability to act against S. flexneri infections	2380:2438	Therefore, L-EPSs were shown to be bioactive macromolecules with the potential ability to act against S. flexneri infections.
32444475	7	5	theme	acidic	1460:1465	arg1	2-1					1488:1490	the acidic polysaccharide L-EPS 2-1	1456:1490	the acidic polysaccharide L-EPS 2-1	1456:1490	L-EPS was separated into the neutral polysaccharide L-EPS 1-1 and the acidic polysaccharide L-EPS 2-1 by ion-exchange chromatography and gel chromatography.
32444475	4	6	theme	HT-29	887:891	arg1	monolayers					898:907	HT-29 cell monolayers	887:907	HT-29 cell monolayers	887:907	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	4	7	theme	S.	704:705	arg1	L-EPS					716:720	S. flexneri L-EPS	704:720	S. flexneri L-EPS	704:720	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	10	8	theme	developing	1839:1848	arg1	countries					1850:1858	developing countries	1839:1858	developing countries	1839:1858	flexneri is a widespread foodborne pathogen causing food contamination and responsible for food poisoning outbreaks related to various foods in developing countries.
32444475	4	9	theme	flexneri	940:947	arg1	disturbance					957:967	S. flexneri biofilm disturbance	937:967	S. flexneri biofilm disturbance by L-EPS	937:976	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	4	10	theme	flexneri	662:669	arg1	matrix					649:654	the extracellular polymeric matrix	621:654	the extracellular polymeric matrix of S. flexneri	621:669	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	4	11	theme	minimum	741:747	arg1	MBEC					784:787	MBEC	784:787	MBEC	784:787	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	4	11	theme	minimum	741:747	arg1	concentration					769:781	the minimum biofilm elimination concentration	737:781	the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm	737:831	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	11	12	theme	biofilm	1874:1880	arg1	formation					1882:1890	biofilm formation	1874:1890	biofilm formation by S. flexneri	1874:1905	Not only has biofilm formation by S. flexneri been difficult to eliminate, but it has also increased the drug resistance of the strain.
32444475	13	13	theme	flexneri	2297:2304	arg1	biofilm					2306:2312	S. flexneri biofilm	2294:2312	S. flexneri biofilm	2294:2312	Also, L-EPSs could decrease the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm.
32444475	4	14	theme	elimination	757:767	arg1	MBEC					784:787	MBEC	784:787	MBEC	784:787	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	4	14	theme	elimination	757:767	arg1	concentration					769:781	the minimum biofilm elimination concentration	737:781	the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm	737:831	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	2	15	theme	strains	286:292	arg1	emergence					252:260	the emergence	248:260	the emergence of antibiotic-resistant strains, which poses serious threats to food safety and human health	248:353	Biofilm formation by S. flexneri can cause the emergence of antibiotic-resistant strains, which poses serious threats to food safety and human health.
32444475	6	16	theme	molar	1204:1208	arg1	ratio					1210:1214	the molar ratio	1200:1214	the molar ratio of 32.26:0.99:1.79:5.63:0.05:4.07	1200:1248	The monosaccharide composition analysis showed that L-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, galactose, and xylose, with the molar ratio of 32.26:0.99:1.79:5.63:0.05:4.07, while S-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, and galactose, with the molar ratio of 25.43:2.28:7.13:5.35.
32444475	0	17	theme	Shigella	78:85	arg1	flexneri					87:94	Shigella flexneri	78:94	Shigella flexneri	78:94	Antibiofilm Activity of Lactobacillus plantarum 12 Exopolysaccharides against Shigella flexneri.
32444475	1	18	theme	enteric	159:165	arg1	flexneri					131:138	Shigella flexneri	122:138	Shigella flexneri	122:138	In developing countries, Shigella flexneri is the most common enteric pathogen causing bacillary dysentery.
32444475	1	18	theme	enteric	159:165	arg1	pathogen					167:174	the most common enteric pathogen	143:174	the most common enteric pathogen causing bacillary dysentery	143:202	In developing countries, Shigella flexneri is the most common enteric pathogen causing bacillary dysentery.
32444475	12	19	theme	S.	2103:2104	arg1	formation					2123:2131	S. flexneri biofilm formation	2103:2131	S. flexneri biofilm formation on	2103:2134	In the present study, it was demonstrated that L-EPSs secreted by Lactobacillus plantrum 12 could inhibit S. flexneri biofilm formation on, adhesion to, and invasion into HT-29 cells.
32444475	6	20	theme	25.43:2.28:7.13:5.35	1368:1387	arg1	ratio					1359:1363	the molar ratio	1349:1363	the molar ratio of 25.43:2.28:7.13:5.35	1349:1387	The monosaccharide composition analysis showed that L-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, galactose, and xylose, with the molar ratio of 32.26:0.99:1.79:5.63:0.05:4.07, while S-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, and galactose, with the molar ratio of 25.43:2.28:7.13:5.35.
32444475	1	21	from	pathogen	167:174	arg1	countries					111:119	developing countries	100:119	developing countries	100:119	In developing countries, Shigella flexneri is the most common enteric pathogen causing bacillary dysentery.
32444475	4	22	theme	antibiotics	793:803	arg1	MBEC					784:787	MBEC	784:787	MBEC	784:787	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	4	22	theme	antibiotics	793:803	arg1	concentration					769:781	the minimum biofilm elimination concentration	737:781	the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm	737:831	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	9	23	theme	antibiofilm	1613:1623	arg1	activity					1625:1632	The antibiofilm activity	1609:1632	The antibiofilm activity of L-EPS	1609:1641	The antibiofilm activity of L-EPS might be associated with its structure.IMPORTANCES.
32444475	3	24	from	effects	375:381	arg1	formation					518:526	S. flexneri CMCC51574 biofilm formation	488:526	S. flexneri CMCC51574 biofilm formation	488:526	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	8	25	theme	L-EPS	1547:1551	arg1	2-1					1553:1555	L-EPS 2-1	1547:1555	L-EPS 2-1	1547:1555	L-EPS 2-1 exerted higher antibiofilm activity than L-EPS 1-1.
32444475	4	26	theme	S.	813:814	arg1	biofilm					825:831	S. flexneri biofilm	813:831	S. flexneri biofilm	813:831	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	3	27	theme	S.	445:446	arg1	S-EPSs					477:482	S-EPSs	477:482	S-EPSs	477:482	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	3	27	theme	S.	445:446	arg1	exopolysaccharides					457:474	S. flexneri exopolysaccharides	445:474	S. flexneri exopolysaccharides (S-EPSs)	445:483	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	3	28	theme	Lactobacillus	386:398	arg1	exopolysaccharides					413:430	12 exopolysaccharides	410:430	12 exopolysaccharides (L-EPSs)	410:439	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	3	28	theme	Lactobacillus	386:398	arg1	L-EPSs					433:438	L-EPSs	433:438	L-EPSs	433:438	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	8	29	theme	antibiofilm	1572:1582	arg1	activity					1584:1591	higher antibiofilm activity	1565:1591	higher antibiofilm activity	1565:1591	L-EPS 2-1 exerted higher antibiofilm activity than L-EPS 1-1.
32444475	1	30	theme	Shigella	122:129	arg1	flexneri					131:138	Shigella flexneri	122:138	Shigella flexneri	122:138	In developing countries, Shigella flexneri is the most common enteric pathogen causing bacillary dysentery.
32444475	1	30	theme	Shigella	122:129	arg1	pathogen					167:174	the most common enteric pathogen	143:174	the most common enteric pathogen causing bacillary dysentery	143:202	In developing countries, Shigella flexneri is the most common enteric pathogen causing bacillary dysentery.
32444475	12	31	theme	biofilm	2115:2121	arg1	formation					2123:2131	S. flexneri biofilm formation	2103:2131	S. flexneri biofilm formation on	2103:2134	In the present study, it was demonstrated that L-EPSs secreted by Lactobacillus plantrum 12 could inhibit S. flexneri biofilm formation on, adhesion to, and invasion into HT-29 cells.
32444475	3	32	theme	exopolysaccharides	457:474	arg1	effects					375:381	the effects	371:381	the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation	371:526	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	4	33	theme	flexneri	848:855	arg1	adhesion					857:864	S. flexneri adhesion	845:864	S. flexneri adhesion to	845:867	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	11	34	theme	drug	1966:1969	arg1	resistance					1971:1980	the drug resistance	1962:1980	the drug resistance of the strain	1962:1994	Not only has biofilm formation by S. flexneri been difficult to eliminate, but it has also increased the drug resistance of the strain.
32444475	0	35	theme	plantarum	38:46	arg1	Exopolysaccharides					51:68	Lactobacillus plantarum 12 Exopolysaccharides	24:68	Lactobacillus plantarum 12 Exopolysaccharides	24:68	Antibiofilm Activity of Lactobacillus plantarum 12 Exopolysaccharides against Shigella flexneri.
32444475	13	36	theme	minimum	2213:2219	arg1	MBEC					2256:2259	MBEC	2256:2259	MBEC	2256:2259	Also, L-EPSs could decrease the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm.
32444475	13	36	theme	minimum	2213:2219	arg1	concentration					2241:2253	the minimum biofilm elimination concentration	2209:2253	the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm	2209:2312	Also, L-EPSs could decrease the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm.
32444475	6	37	theme	monosaccharide	1052:1065	arg1	analysis					1079:1086	The monosaccharide composition analysis	1048:1086	The monosaccharide composition analysis	1048:1086	The monosaccharide composition analysis showed that L-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, galactose, and xylose, with the molar ratio of 32.26:0.99:1.79:5.63:0.05:4.07, while S-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, and galactose, with the molar ratio of 25.43:2.28:7.13:5.35.
32444475	3	38	theme	flexneri	491:498	arg1	formation					518:526	S. flexneri CMCC51574 biofilm formation	488:526	S. flexneri CMCC51574 biofilm formation	488:526	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	0	39	theme	Exopolysaccharides	51:68	arg1	Activity					12:19	Activity	12:19	Activity of Lactobacillus plantarum 12 Exopolysaccharides against Shigella flexneri	12:94	Antibiofilm Activity of Lactobacillus plantarum 12 Exopolysaccharides against Shigella flexneri.
32444475	13	40	theme	elimination	2229:2239	arg1	MBEC					2256:2259	MBEC	2256:2259	MBEC	2256:2259	Also, L-EPSs could decrease the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm.
32444475	13	40	theme	elimination	2229:2239	arg1	concentration					2241:2253	the minimum biofilm elimination concentration	2209:2253	the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm	2209:2312	Also, L-EPSs could decrease the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm.
32444475	2	41	theme	S.	226:227	arg1	flexneri					229:236	S. flexneri	226:236	S. flexneri	226:236	Biofilm formation by S. flexneri can cause the emergence of antibiotic-resistant strains, which poses serious threats to food safety and human health.
32444475	10	42	theme	food	1747:1750	arg1	contamination					1752:1764	food contamination	1747:1764	food contamination	1747:1764	flexneri is a widespread foodborne pathogen causing food contamination and responsible for food poisoning outbreaks related to various foods in developing countries.
32444475	5	43	theme	opposite	1012:1019	arg1	effects					1021:1027	the opposite effects	1008:1027	the opposite effects	1008:1027	In contrast, S-EPS exhibited the opposite effects compared to L-EPS.
32444475	13	44	theme	antibiotics	2269:2279	arg1	MBEC					2256:2259	MBEC	2256:2259	MBEC	2256:2259	Also, L-EPSs could decrease the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm.
32444475	13	44	theme	antibiotics	2269:2279	arg1	concentration					2241:2253	the minimum biofilm elimination concentration	2209:2253	the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm	2209:2312	Also, L-EPSs could decrease the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm.
32444475	4	45	theme	extracellular	625:637	arg1	matrix					649:654	the extracellular polymeric matrix	621:654	the extracellular polymeric matrix of S. flexneri	621:669	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	7	46	theme	ion-exchange	1495:1506	arg1	chromatography					1508:1521	ion-exchange chromatography	1495:1521	ion-exchange chromatography	1495:1521	L-EPS was separated into the neutral polysaccharide L-EPS 1-1 and the acidic polysaccharide L-EPS 2-1 by ion-exchange chromatography and gel chromatography.
32444475	14	47	theme	S.	2417:2418	arg1	infections					2429:2438	S. flexneri infections	2417:2438	S. flexneri infections	2417:2438	Therefore, L-EPSs were shown to be bioactive macromolecules with the potential ability to act against S. flexneri infections.
32444475	3	48	theme	biofilm	510:516	arg1	formation					518:526	S. flexneri CMCC51574 biofilm formation	488:526	S. flexneri CMCC51574 biofilm formation	488:526	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	12	49	theme	Lactobacillus	2063:2075	arg1	plantrum					2077:2084	Lactobacillus plantrum 12	2063:2087	Lactobacillus plantrum 12	2063:2087	In the present study, it was demonstrated that L-EPSs secreted by Lactobacillus plantrum 12 could inhibit S. flexneri biofilm formation on, adhesion to, and invasion into HT-29 cells.
32444475	4	50	theme	cell	893:896	arg1	monolayers					898:907	HT-29 cell monolayers	887:907	HT-29 cell monolayers	887:907	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	4	51	theme	polysaccharide	592:605	arg1	production					607:616	polysaccharide production	592:616	polysaccharide production in the extracellular polymeric matrix of S. flexneri	592:669	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	6	52	theme	glucuronic	1288:1297	arg1	acid					1299:1302	glucuronic acid	1288:1302	glucuronic acid	1288:1302	The monosaccharide composition analysis showed that L-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, galactose, and xylose, with the molar ratio of 32.26:0.99:1.79:5.63:0.05:4.07, while S-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, and galactose, with the molar ratio of 25.43:2.28:7.13:5.35.
32444475	10	53	theme	various	1822:1828	arg1	foods					1830:1834	various foods	1822:1834	various foods in developing countries	1822:1858	flexneri is a widespread foodborne pathogen causing food contamination and responsible for food poisoning outbreaks related to various foods in developing countries.
32444475	7	54	theme	polysaccharide	1467:1480	arg1	2-1					1488:1490	the acidic polysaccharide L-EPS 2-1	1456:1490	the acidic polysaccharide L-EPS 2-1	1456:1490	L-EPS was separated into the neutral polysaccharide L-EPS 1-1 and the acidic polysaccharide L-EPS 2-1 by ion-exchange chromatography and gel chromatography.
32444475	10	55	theme	related	1811:1817	arg1	outbreaks					1801:1809	responsible for food poisoning outbreaks	1770:1809	responsible for food poisoning outbreaks related to various foods in developing countries	1770:1858	flexneri is a widespread foodborne pathogen causing food contamination and responsible for food poisoning outbreaks related to various foods in developing countries.
32444475	12	56	theme	HT-29	2168:2172	arg1	cells					2174:2178	HT-29 cells	2168:2178	HT-29 cells	2168:2178	In the present study, it was demonstrated that L-EPSs secreted by Lactobacillus plantrum 12 could inhibit S. flexneri biofilm formation on, adhesion to, and invasion into HT-29 cells.
32444475	1	57	theme	bacillary	184:192	arg1	dysentery					194:202	bacillary dysentery	184:202	bacillary dysentery	184:202	In developing countries, Shigella flexneri is the most common enteric pathogen causing bacillary dysentery.
32444475	10	58	theme	widespread	1709:1718	arg1	flexneri					1695:1702	flexneri	1695:1702	flexneri	1695:1702	flexneri is a widespread foodborne pathogen causing food contamination and responsible for food poisoning outbreaks related to various foods in developing countries.
32444475	10	58	theme	widespread	1709:1718	arg1	pathogen					1730:1737	a widespread foodborne pathogen	1707:1737	a widespread foodborne pathogen causing food contamination and responsible for food poisoning outbreaks related to various foods in developing countries	1707:1858	flexneri is a widespread foodborne pathogen causing food contamination and responsible for food poisoning outbreaks related to various foods in developing countries.
32444475	7	59	theme	L-EPS	1442:1446	arg1	1-1					1448:1450	the neutral polysaccharide L-EPS 1-1	1415:1450	the neutral polysaccharide L-EPS 1-1	1415:1450	L-EPS was separated into the neutral polysaccharide L-EPS 1-1 and the acidic polysaccharide L-EPS 2-1 by ion-exchange chromatography and gel chromatography.
32444475	4	60	theme	biofilm	683:689	arg1	formation					691:699	biofilm formation	683:699	biofilm formation	683:699	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	12	61	theme	present	2004:2010	arg1	study					2012:2016	the present study	2000:2016	the present study	2000:2016	In the present study, it was demonstrated that L-EPSs secreted by Lactobacillus plantrum 12 could inhibit S. flexneri biofilm formation on, adhesion to, and invasion into HT-29 cells.
32444475	7	62	theme	neutral	1419:1425	arg1	1-1					1448:1450	the neutral polysaccharide L-EPS 1-1	1415:1450	the neutral polysaccharide L-EPS 1-1	1415:1450	L-EPS was separated into the neutral polysaccharide L-EPS 1-1 and the acidic polysaccharide L-EPS 2-1 by ion-exchange chromatography and gel chromatography.
32444475	2	63	theme	food	326:329	arg1	safety					331:336	food safety	326:336	food safety	326:336	Biofilm formation by S. flexneri can cause the emergence of antibiotic-resistant strains, which poses serious threats to food safety and human health.
32444475	4	64	theme	S.	937:938	arg1	disturbance					957:967	S. flexneri biofilm disturbance	937:967	S. flexneri biofilm disturbance by L-EPS	937:976	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	4	65	theme	S.	659:660	arg1	flexneri					662:669	S. flexneri	659:669	S. flexneri	659:669	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	4	66	theme	biofilm	949:955	arg1	disturbance					957:967	S. flexneri biofilm disturbance	937:967	S. flexneri biofilm disturbance by L-EPS	937:976	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	11	67	theme	S.	1895:1896	arg1	flexneri					1898:1905	S. flexneri	1895:1905	S. flexneri	1895:1905	Not only has biofilm formation by S. flexneri been difficult to eliminate, but it has also increased the drug resistance of the strain.
32444475	11	68	theme	strain	1989:1994	arg1	resistance					1971:1980	the drug resistance	1962:1980	the drug resistance of the strain	1962:1994	Not only has biofilm formation by S. flexneri been difficult to eliminate, but it has also increased the drug resistance of the strain.
32444475	13	69	theme	S.	2294:2295	arg1	biofilm					2306:2312	S. flexneri biofilm	2294:2312	S. flexneri biofilm	2294:2312	Also, L-EPSs could decrease the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm.
32444475	6	70	theme	32.26:0.99:1.79:5.63:0.05:4.07	1219:1248	arg1	ratio					1210:1214	the molar ratio	1200:1214	the molar ratio of 32.26:0.99:1.79:5.63:0.05:4.07	1200:1248	The monosaccharide composition analysis showed that L-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, galactose, and xylose, with the molar ratio of 32.26:0.99:1.79:5.63:0.05:4.07, while S-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, and galactose, with the molar ratio of 25.43:2.28:7.13:5.35.
32444475	12	71	theme	flexneri	2106:2113	arg1	formation					2123:2131	S. flexneri biofilm formation	2103:2131	S. flexneri biofilm formation on	2103:2134	In the present study, it was demonstrated that L-EPSs secreted by Lactobacillus plantrum 12 could inhibit S. flexneri biofilm formation on, adhesion to, and invasion into HT-29 cells.
32444475	14	72	theme	bioactive	2350:2358	arg1	macromolecules					2360:2373	bioactive macromolecules	2350:2373	bioactive macromolecules	2350:2373	Therefore, L-EPSs were shown to be bioactive macromolecules with the potential ability to act against S. flexneri infections.
32444475	4	73	theme	biofilm	749:755	arg1	MBEC					784:787	MBEC	784:787	MBEC	784:787	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	4	73	theme	biofilm	749:755	arg1	concentration					769:781	the minimum biofilm elimination concentration	737:781	the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm	737:831	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	2	74	theme	antibiotic-resistant	265:284	arg1	strains					286:292	antibiotic-resistant strains	265:292	antibiotic-resistant strains	265:292	Biofilm formation by S. flexneri can cause the emergence of antibiotic-resistant strains, which poses serious threats to food safety and human health.
32444475	1	75	theme	common	152:157	arg1	flexneri					131:138	Shigella flexneri	122:138	Shigella flexneri	122:138	In developing countries, Shigella flexneri is the most common enteric pathogen causing bacillary dysentery.
32444475	1	75	theme	common	152:157	arg1	pathogen					167:174	the most common enteric pathogen	143:174	the most common enteric pathogen causing bacillary dysentery	143:202	In developing countries, Shigella flexneri is the most common enteric pathogen causing bacillary dysentery.
32444475	4	76	theme	flexneri	707:714	arg1	L-EPS					716:720	S. flexneri L-EPS	704:720	S. flexneri L-EPS	704:720	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	10	77	from	foods	1830:1834	arg1	countries					1850:1858	developing countries	1839:1858	developing countries	1839:1858	flexneri is a widespread foodborne pathogen causing food contamination and responsible for food poisoning outbreaks related to various foods in developing countries.
32444475	2	78	theme	human	342:346	arg1	health					348:353	human health	342:353	human health	342:353	Biofilm formation by S. flexneri can cause the emergence of antibiotic-resistant strains, which poses serious threats to food safety and human health.
32444475	4	79	from	production	607:616	arg1	matrix					649:654	the extracellular polymeric matrix	621:654	the extracellular polymeric matrix of S. flexneri	621:669	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	8	80	theme	higher	1565:1570	arg1	activity					1584:1591	higher antibiofilm activity	1565:1591	higher antibiofilm activity	1565:1591	L-EPS 2-1 exerted higher antibiofilm activity than L-EPS 1-1.
32444475	3	81	dep	exopolysaccharides	413:430	arg1	plantarum					400:408	Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs)	386:483	plantarum	400:408	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	6	82	theme	molar	1353:1357	arg1	ratio					1359:1363	the molar ratio	1349:1363	the molar ratio of 25.43:2.28:7.13:5.35	1349:1387	The monosaccharide composition analysis showed that L-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, galactose, and xylose, with the molar ratio of 32.26:0.99:1.79:5.63:0.05:4.07, while S-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, and galactose, with the molar ratio of 25.43:2.28:7.13:5.35.
32444475	1	83	theme	developing	100:109	arg1	countries					111:119	developing countries	100:119	developing countries	100:119	In developing countries, Shigella flexneri is the most common enteric pathogen causing bacillary dysentery.
32444475	0	84	theme	Lactobacillus	24:36	arg1	Exopolysaccharides					51:68	Lactobacillus plantarum 12 Exopolysaccharides	24:68	Lactobacillus plantarum 12 Exopolysaccharides	24:68	Antibiofilm Activity of Lactobacillus plantarum 12 Exopolysaccharides against Shigella flexneri.
32444475	8	85	theme	L-EPS	1598:1602	arg1	1-1					1604:1606	L-EPS 1-1	1598:1606	L-EPS 1-1	1598:1606	L-EPS 2-1 exerted higher antibiofilm activity than L-EPS 1-1.
32444475	2	86	theme	Biofilm	205:211	arg1	formation					213:221	Biofilm formation	205:221	Biofilm formation by S. flexneri	205:236	Biofilm formation by S. flexneri can cause the emergence of antibiotic-resistant strains, which poses serious threats to food safety and human health.
32444475	10	87	theme	foodborne	1720:1728	arg1	flexneri					1695:1702	flexneri	1695:1702	flexneri	1695:1702	flexneri is a widespread foodborne pathogen causing food contamination and responsible for food poisoning outbreaks related to various foods in developing countries.
32444475	10	87	theme	foodborne	1720:1728	arg1	pathogen					1730:1737	a widespread foodborne pathogen	1707:1737	a widespread foodborne pathogen causing food contamination and responsible for food poisoning outbreaks related to various foods in developing countries	1707:1858	flexneri is a widespread foodborne pathogen causing food contamination and responsible for food poisoning outbreaks related to various foods in developing countries.
32444475	6	88	theme	composition	1067:1077	arg1	analysis					1079:1086	The monosaccharide composition analysis	1048:1086	The monosaccharide composition analysis	1048:1086	The monosaccharide composition analysis showed that L-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, galactose, and xylose, with the molar ratio of 32.26:0.99:1.79:5.63:0.05:4.07, while S-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, and galactose, with the molar ratio of 25.43:2.28:7.13:5.35.
32444475	4	89	theme	S.	845:846	arg1	adhesion					857:864	S. flexneri adhesion	845:864	S. flexneri adhesion to	845:867	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	13	90	theme	biofilm	2221:2227	arg1	MBEC					2256:2259	MBEC	2256:2259	MBEC	2256:2259	Also, L-EPSs could decrease the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm.
32444475	13	90	theme	biofilm	2221:2227	arg1	concentration					2241:2253	the minimum biofilm elimination concentration	2209:2253	the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm	2209:2312	Also, L-EPSs could decrease the minimum biofilm elimination concentration (MBEC) of the antibiotics used against S. flexneri biofilm.
32444475	9	91	theme	L-EPS	1637:1641	arg1	activity					1625:1632	The antibiofilm activity	1609:1632	The antibiofilm activity of L-EPS	1609:1641	The antibiofilm activity of L-EPS might be associated with its structure.IMPORTANCES.
32444475	3	92	theme	exopolysaccharides	413:430	arg1	effects					375:381	the effects	371:381	the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation	371:526	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	14	93	with	macromolecules	2360:2373	arg1	ability					2394:2400	the potential ability	2380:2400	the potential ability to act against S. flexneri infections	2380:2438	Therefore, L-EPSs were shown to be bioactive macromolecules with the potential ability to act against S. flexneri infections.
32444475	3	94	theme	CMCC51574	500:508	arg1	formation					518:526	S. flexneri CMCC51574 biofilm formation	488:526	S. flexneri CMCC51574 biofilm formation	488:526	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	4	95	theme	polymeric	639:647	arg1	matrix					649:654	the extracellular polymeric matrix	621:654	the extracellular polymeric matrix of S. flexneri	621:669	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	4	96	theme	flexneri	816:823	arg1	biofilm					825:831	S. flexneri biofilm	813:831	S. flexneri biofilm	813:831	The results showed that L-EPS could decrease polysaccharide production in the extracellular polymeric matrix of S. flexneri and inhibit biofilm formation by S. flexneri L-EPS could decrease the minimum biofilm elimination concentration (MBEC) of antibiotics against S. flexneri biofilm and inhibit S. flexneri adhesion to and invasion into HT-29 cell monolayers, which might be ascribed to S. flexneri biofilm disturbance by L-EPS.
32444475	3	97	theme	S.	488:489	arg1	formation					518:526	S. flexneri CMCC51574 biofilm formation	488:526	S. flexneri CMCC51574 biofilm formation	488:526	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	7	98	theme	gel	1527:1529	arg1	chromatography					1531:1544	gel chromatography	1527:1544	gel chromatography	1527:1544	L-EPS was separated into the neutral polysaccharide L-EPS 1-1 and the acidic polysaccharide L-EPS 2-1 by ion-exchange chromatography and gel chromatography.
32444475	6	99	theme	glucuronic	1131:1140	arg1	acid					1142:1145	glucuronic acid	1131:1145	glucuronic acid	1131:1145	The monosaccharide composition analysis showed that L-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, galactose, and xylose, with the molar ratio of 32.26:0.99:1.79:5.63:0.05:4.07, while S-EPS was composed of mannose, glucuronic acid, galactosamine, glucose, and galactose, with the molar ratio of 25.43:2.28:7.13:5.35.
32444475	3	100	theme	flexneri	448:455	arg1	S-EPSs					477:482	S-EPSs	477:482	S-EPSs	477:482	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	3	100	theme	flexneri	448:455	arg1	exopolysaccharides					457:474	S. flexneri exopolysaccharides	445:474	S. flexneri exopolysaccharides (S-EPSs)	445:483	In this study, the effects of Lactobacillus plantarum 12 exopolysaccharides (L-EPSs) and S. flexneri exopolysaccharides (S-EPSs) on S. flexneri CMCC51574 biofilm formation were investigated.
32444475	14	101	theme	flexneri	2420:2427	arg1	infections					2429:2438	S. flexneri infections	2417:2438	S. flexneri infections	2417:2438	Therefore, L-EPSs were shown to be bioactive macromolecules with the potential ability to act against S. flexneri infections.
32444475	10	102	theme	food	1786:1789	arg1	poisoning					1791:1799	food poisoning	1786:1799	food poisoning	1786:1799	flexneri is a widespread foodborne pathogen causing food contamination and responsible for food poisoning outbreaks related to various foods in developing countries.
34004124	4	0	with	hydrogel	707:714	arg1	elasticity					743:752	elasticity	743:752	elasticity	743:752	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	4	0	with	hydrogel	707:714	arg1	strength					730:737	enhanced strength	721:737	enhanced strength	721:737	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	2	1	theme	attractive	346:355	arg1	scaffolds					367:375	the most attractive candidate scaffolds	337:375	the most attractive candidate scaffolds for tissue engineering	337:398	SF-based hydrogels have been identified as one of the most attractive candidate scaffolds for tissue engineering and can be fabricated through various physical or chemical crosslinking approaches.
34004124	8	2	theme	crosslinking	1510:1521	arg1	strategies					1523:1532	physical and enzymatic crosslinking strategies	1487:1532	physical and enzymatic crosslinking strategies	1487:1532	The combination of physical and enzymatic crosslinking strategies contributes to a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine.
34004124	4	3	theme	enhanced	721:728	arg1	strength					730:737	enhanced strength	721:737	enhanced strength	721:737	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	4	4	theme	β-sheet	816:822	arg1	structures					824:833	uniform and small β-sheet structures	798:833	uniform and small β-sheet structures	798:833	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	4	5	link	crosslinked	676:686	arg1	hydrogel					707:714	a dually crosslinked SF-based composite hydrogel	667:714	a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity	667:752	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	2	6	theme	SF-based	287:294	arg1	one					330:332	one	330:332	one	330:332	SF-based hydrogels have been identified as one of the most attractive candidate scaffolds for tissue engineering and can be fabricated through various physical or chemical crosslinking approaches.
34004124	2	6	theme	SF-based	287:294	arg1	hydrogels					296:304	SF-based hydrogels	287:304	SF-based hydrogels	287:304	SF-based hydrogels have been identified as one of the most attractive candidate scaffolds for tissue engineering and can be fabricated through various physical or chemical crosslinking approaches.
34004124	2	6	theme	SF-based	287:294	arg1	scaffolds					367:375	the most attractive candidate scaffolds	337:375	the most attractive candidate scaffolds for tissue engineering	337:398	SF-based hydrogels have been identified as one of the most attractive candidate scaffolds for tissue engineering and can be fabricated through various physical or chemical crosslinking approaches.
34004124	4	7	from	sonication	838:847	arg1	network					890:896	a restricted enzymatic precrosslinked network	852:896	a restricted enzymatic precrosslinked network	852:896	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	6	8	theme	experimental	1074:1085	arg1	results					1087:1093	subsequent experimental results	1063:1093	subsequent experimental results	1063:1093	Moreover, subsequent experimental results revealed that the hydrogels exhibit other advantages, including high water retention capacity and long-term stability under physiological conditions.
34004124	8	9	theme	physical	1487:1494	arg1	strategies					1523:1532	physical and enzymatic crosslinking strategies	1487:1532	physical and enzymatic crosslinking strategies	1487:1532	The combination of physical and enzymatic crosslinking strategies contributes to a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine.
34004124	5	10	theme	stiffness	968:976	arg1	variation					978:986	concentration-dependent stiffness variation	944:986	concentration-dependent stiffness variation	944:986	The composite hydrogel not only demonstrated concentration-dependent stiffness variation but also exhibited time-dependent changes in toughness behavior.
34004124	3	11	theme	conventional	493:504	arg1	hydrogels					509:517	conventional SF hydrogels	493:517	conventional SF hydrogels	493:517	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	7	12	theme	cell-laden	1297:1306	arg1	hydrogel					1308:1315	the cell-laden hydrogel	1293:1315	the cell-laden hydrogel	1293:1315	Finally, a three-dimensional (3 D) construct of the cell-laden hydrogel was fabricated, confirming that the composite hydrogel could provide a biocompatible microenvironment with dynamically changing mechanical properties.
34004124	3	13	theme	major	543:547	arg1	properties					610:619	poor mechanical properties	594:619	poor mechanical properties	594:619	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	3	13	theme	major	543:547	arg1	inhomogeneity					579:591	structural inhomogeneity	568:591	structural inhomogeneity	568:591	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	3	13	theme	major	543:547	arg1	drawbacks					549:557	several major drawbacks	535:557	several major drawbacks	535:557	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	3	13	theme	major	543:547	arg1	utilization					624:634	utilization	624:634	utilization of cytotoxic reagents	624:656	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	4	14	theme	composite	697:705	arg1	hydrogel					707:714	a dually crosslinked SF-based composite hydrogel	667:714	a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity	667:752	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	4	15	theme	crosslinked	676:686	arg1	hydrogel					707:714	a dually crosslinked SF-based composite hydrogel	667:714	a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity	667:752	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	0	16	theme	physical	111:118	arg1	crosslinking					134:145	physical and enzymatic crosslinking	111:145	physical and enzymatic crosslinking	111:145	Preparation of silk fibroin/hyaluronic acid hydrogels with enhanced mechanical performance by a combination of physical and enzymatic crosslinking.
34004124	4	17	theme	precrosslinked	875:888	arg1	network					890:896	a restricted enzymatic precrosslinked network	852:896	a restricted enzymatic precrosslinked network	852:896	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	8	18	theme	enzymatic	1500:1508	arg1	strategies					1523:1532	physical and enzymatic crosslinking strategies	1487:1532	physical and enzymatic crosslinking strategies	1487:1532	The combination of physical and enzymatic crosslinking strategies contributes to a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine.
34004124	6	19	theme	long-term	1193:1201	arg1	stability					1203:1211	long-term stability	1193:1211	long-term stability	1193:1211	Moreover, subsequent experimental results revealed that the hydrogels exhibit other advantages, including high water retention capacity and long-term stability under physiological conditions.
34004124	1	20	theme	Bombyx	171:176	arg1	mori					178:181	Bombyx mori	171:181	Bombyx mori	171:181	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	2	21	theme	chemical	450:457	arg1	approaches					472:481	various physical or chemical crosslinking approaches	430:481	various physical or chemical crosslinking approaches	430:481	SF-based hydrogels have been identified as one of the most attractive candidate scaffolds for tissue engineering and can be fabricated through various physical or chemical crosslinking approaches.
34004124	3	22	theme	several	535:541	arg1	properties					610:619	poor mechanical properties	594:619	poor mechanical properties	594:619	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	3	22	theme	several	535:541	arg1	inhomogeneity					579:591	structural inhomogeneity	568:591	structural inhomogeneity	568:591	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	3	22	theme	several	535:541	arg1	drawbacks					549:557	several major drawbacks	535:557	several major drawbacks	535:557	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	3	22	theme	several	535:541	arg1	utilization					624:634	utilization	624:634	utilization of cytotoxic reagents	624:656	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	7	23	with	microenvironment	1402:1417	arg1	properties					1456:1465	dynamically changing mechanical properties	1424:1465	dynamically changing mechanical properties	1424:1465	Finally, a three-dimensional (3 D) construct of the cell-laden hydrogel was fabricated, confirming that the composite hydrogel could provide a biocompatible microenvironment with dynamically changing mechanical properties.
34004124	6	24	theme	subsequent	1063:1072	arg1	results					1087:1093	subsequent experimental results	1063:1093	subsequent experimental results	1063:1093	Moreover, subsequent experimental results revealed that the hydrogels exhibit other advantages, including high water retention capacity and long-term stability under physiological conditions.
34004124	7	25	theme	biocompatible	1388:1400	arg1	microenvironment					1402:1417	a biocompatible microenvironment	1386:1417	a biocompatible microenvironment with dynamically changing mechanical properties	1386:1465	Finally, a three-dimensional (3 D) construct of the cell-laden hydrogel was fabricated, confirming that the composite hydrogel could provide a biocompatible microenvironment with dynamically changing mechanical properties.
34004124	2	26	theme	tissue	381:386	arg1	engineering					388:398	tissue engineering	381:398	tissue engineering	381:398	SF-based hydrogels have been identified as one of the most attractive candidate scaffolds for tissue engineering and can be fabricated through various physical or chemical crosslinking approaches.
34004124	6	27	theme	other	1131:1135	arg1	advantages					1137:1146	other advantages	1131:1146	other advantages	1131:1146	Moreover, subsequent experimental results revealed that the hydrogels exhibit other advantages, including high water retention capacity and long-term stability under physiological conditions.
34004124	4	28	link	precrosslinked	875:888	arg1	network					890:896	a restricted enzymatic precrosslinked network	852:896	a restricted enzymatic precrosslinked network	852:896	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	8	29	theme	tissue	1656:1661	arg1	engineering					1663:1673	tissue engineering	1656:1673	tissue engineering	1656:1673	The combination of physical and enzymatic crosslinking strategies contributes to a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine.
34004124	5	30	theme	composite	903:911	arg1	hydrogel					913:920	The composite hydrogel	899:920	The composite hydrogel	899:920	The composite hydrogel not only demonstrated concentration-dependent stiffness variation but also exhibited time-dependent changes in toughness behavior.
34004124	8	31	theme	strategies	1523:1532	arg1	combination					1472:1482	The combination	1468:1482	The combination of physical and enzymatic crosslinking strategies	1468:1532	The combination of physical and enzymatic crosslinking strategies contributes to a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine.
34004124	4	32	theme	uniform	798:804	arg1	structures					824:833	uniform and small β-sheet structures	798:833	uniform and small β-sheet structures	798:833	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	4	33	theme	SF-based	688:695	arg1	hydrogel					707:714	a dually crosslinked SF-based composite hydrogel	667:714	a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity	667:752	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	0	34	theme	fibroin/hyaluronic	20:37	arg1	hydrogels					44:52	silk fibroin/hyaluronic acid hydrogels	15:52	silk fibroin/hyaluronic acid hydrogels	15:52	Preparation of silk fibroin/hyaluronic acid hydrogels with enhanced mechanical performance by a combination of physical and enzymatic crosslinking.
34004124	1	35	theme	processability	271:284	arg1	biocompatibility					221:236	exceptional biocompatibility	209:236	exceptional biocompatibility	209:236	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	1	35	theme	processability	271:284	arg1	immunogenicity					243:256	low immunogenicity	239:256	low immunogenicity	239:256	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	1	35	theme	processability	271:284	arg1	ease					263:266	ease	263:266	ease of processability	263:284	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	0	36	theme	crosslinking	134:145	arg1	combination					96:106	a combination	94:106	a combination of physical and enzymatic crosslinking	94:145	Preparation of silk fibroin/hyaluronic acid hydrogels with enhanced mechanical performance by a combination of physical and enzymatic crosslinking.
34004124	4	37	theme	restricted	854:863	arg1	network					890:896	a restricted enzymatic precrosslinked network	852:896	a restricted enzymatic precrosslinked network	852:896	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	4	38	theme	enzymatic	865:873	arg1	network					890:896	a restricted enzymatic precrosslinked network	852:896	a restricted enzymatic precrosslinked network	852:896	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	6	39	theme	high	1159:1162	arg1	capacity					1180:1187	high water retention capacity	1159:1187	high water retention capacity	1159:1187	Moreover, subsequent experimental results revealed that the hydrogels exhibit other advantages, including high water retention capacity and long-term stability under physiological conditions.
34004124	2	40	theme	various	430:436	arg1	approaches					472:481	various physical or chemical crosslinking approaches	430:481	various physical or chemical crosslinking approaches	430:481	SF-based hydrogels have been identified as one of the most attractive candidate scaffolds for tissue engineering and can be fabricated through various physical or chemical crosslinking approaches.
34004124	0	41	theme	enzymatic	124:132	arg1	crosslinking					134:145	physical and enzymatic crosslinking	111:145	physical and enzymatic crosslinking	111:145	Preparation of silk fibroin/hyaluronic acid hydrogels with enhanced mechanical performance by a combination of physical and enzymatic crosslinking.
34004124	8	42	theme	great	1629:1633	arg1	potential					1635:1643	great potential	1629:1643	great potential for use	1629:1651	The combination of physical and enzymatic crosslinking strategies contributes to a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine.
34004124	3	43	theme	structural	568:577	arg1	inhomogeneity					579:591	structural inhomogeneity	568:591	structural inhomogeneity	568:591	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	1	44	theme	natural	188:194	arg1	polymer					196:202	a natural polymer	186:202	a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability	186:284	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	1	44	theme	natural	188:194	arg1	fibroin					153:159	Silk fibroin	148:159	Silk fibroin (SF) from Bombyx mori	148:181	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	0	45	theme	hydrogels	44:52	arg1	Preparation					0:10	Preparation	0:10	Preparation of silk fibroin/hyaluronic acid hydrogels with	0:57	Preparation of silk fibroin/hyaluronic acid hydrogels with enhanced mechanical performance by a combination of physical and enzymatic crosslinking.
34004124	7	46	theme	changing	1436:1443	arg1	properties					1456:1465	dynamically changing mechanical properties	1424:1465	dynamically changing mechanical properties	1424:1465	Finally, a three-dimensional (3 D) construct of the cell-laden hydrogel was fabricated, confirming that the composite hydrogel could provide a biocompatible microenvironment with dynamically changing mechanical properties.
34004124	7	47	theme	hydrogel	1308:1315	arg1	construct					1280:1288	a three-dimensional (3 D) construct	1254:1288	a three-dimensional (3 D) construct of the cell-laden hydrogel	1254:1315	Finally, a three-dimensional (3 D) construct of the cell-laden hydrogel was fabricated, confirming that the composite hydrogel could provide a biocompatible microenvironment with dynamically changing mechanical properties.
34004124	8	48	theme	composite	1565:1573	arg1	hydrogel					1575:1582	a biocompatible composite hydrogel	1549:1582	a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine	1549:1699	The combination of physical and enzymatic crosslinking strategies contributes to a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine.
34004124	6	49	theme	water	1164:1168	arg1	capacity					1180:1187	high water retention capacity	1159:1187	high water retention capacity	1159:1187	Moreover, subsequent experimental results revealed that the hydrogels exhibit other advantages, including high water retention capacity and long-term stability under physiological conditions.
34004124	0	50	theme	acid	39:42	arg1	hydrogels					44:52	silk fibroin/hyaluronic acid hydrogels	15:52	silk fibroin/hyaluronic acid hydrogels	15:52	Preparation of silk fibroin/hyaluronic acid hydrogels with enhanced mechanical performance by a combination of physical and enzymatic crosslinking.
34004124	7	51	theme	3 D	1275:1277	arg1	construct					1280:1288	a three-dimensional (3 D) construct	1254:1288	a three-dimensional (3 D) construct of the cell-laden hydrogel	1254:1315	Finally, a three-dimensional (3 D) construct of the cell-laden hydrogel was fabricated, confirming that the composite hydrogel could provide a biocompatible microenvironment with dynamically changing mechanical properties.
34004124	2	52	theme	physical	438:445	arg1	approaches					472:481	various physical or chemical crosslinking approaches	430:481	various physical or chemical crosslinking approaches	430:481	SF-based hydrogels have been identified as one of the most attractive candidate scaffolds for tissue engineering and can be fabricated through various physical or chemical crosslinking approaches.
34004124	6	53	theme	retention	1170:1178	arg1	capacity					1180:1187	high water retention capacity	1159:1187	high water retention capacity	1159:1187	Moreover, subsequent experimental results revealed that the hydrogels exhibit other advantages, including high water retention capacity and long-term stability under physiological conditions.
34004124	8	54	with	hydrogel	1575:1582	arg1	properties					1607:1616	unique mechanical properties	1589:1616	unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine	1589:1699	The combination of physical and enzymatic crosslinking strategies contributes to a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine.
34004124	3	55	theme	poor	594:597	arg1	properties					610:619	poor mechanical properties	594:619	poor mechanical properties	594:619	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	6	56	theme	physiological	1219:1231	arg1	conditions					1233:1242	physiological conditions	1219:1242	physiological conditions	1219:1242	Moreover, subsequent experimental results revealed that the hydrogels exhibit other advantages, including high water retention capacity and long-term stability under physiological conditions.
34004124	3	57	theme	SF	506:507	arg1	hydrogels					509:517	conventional SF hydrogels	493:517	conventional SF hydrogels	493:517	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	2	58	theme	crosslinking	459:470	arg1	approaches					472:481	various physical or chemical crosslinking approaches	430:481	various physical or chemical crosslinking approaches	430:481	SF-based hydrogels have been identified as one of the most attractive candidate scaffolds for tissue engineering and can be fabricated through various physical or chemical crosslinking approaches.
34004124	1	59	with	polymer	196:202	arg1	biocompatibility					221:236	exceptional biocompatibility	209:236	exceptional biocompatibility	209:236	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	1	59	with	polymer	196:202	arg1	immunogenicity					243:256	low immunogenicity	239:256	low immunogenicity	239:256	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	1	59	with	polymer	196:202	arg1	ease					263:266	ease	263:266	ease of processability	263:284	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	3	60	theme	mechanical	599:608	arg1	properties					610:619	poor mechanical properties	594:619	poor mechanical properties	594:619	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	3	61	gly	inhomogeneity	579:591	arg1	reagents					649:656	cytotoxic reagents	639:656	cytotoxic reagents	639:656	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	8	62	theme	mechanical	1596:1605	arg1	properties					1607:1616	unique mechanical properties	1589:1616	unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine	1589:1699	The combination of physical and enzymatic crosslinking strategies contributes to a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine.
34004124	7	63	theme	three-dimensional	1256:1272	arg1	construct					1280:1288	a three-dimensional (3 D) construct	1254:1288	a three-dimensional (3 D) construct of the cell-laden hydrogel	1254:1315	Finally, a three-dimensional (3 D) construct of the cell-laden hydrogel was fabricated, confirming that the composite hydrogel could provide a biocompatible microenvironment with dynamically changing mechanical properties.
34004124	4	64	theme	structures	824:833	arg1	formation					785:793	the formation	781:793	the formation of uniform and small β-sheet structures	781:833	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	3	65	theme	cytotoxic	639:647	arg1	reagents					649:656	cytotoxic reagents	639:656	cytotoxic reagents	639:656	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	8	66	theme	biocompatible	1551:1563	arg1	hydrogel					1575:1582	a biocompatible composite hydrogel	1549:1582	a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine	1549:1699	The combination of physical and enzymatic crosslinking strategies contributes to a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine.
34004124	5	67	theme	toughness	1033:1041	arg1	behavior					1043:1050	toughness behavior	1033:1050	toughness behavior	1033:1050	The composite hydrogel not only demonstrated concentration-dependent stiffness variation but also exhibited time-dependent changes in toughness behavior.
34004124	1	68	theme	exceptional	209:219	arg1	biocompatibility					221:236	exceptional biocompatibility	209:236	exceptional biocompatibility	209:236	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	4	69	theme	small	810:814	arg1	structures					824:833	uniform and small β-sheet structures	798:833	uniform and small β-sheet structures	798:833	Herein, a dually crosslinked SF-based composite hydrogel with enhanced strength and elasticity was fabricated by inducing the formation of uniform and small β-sheet structures by sonication in a restricted enzymatic precrosslinked network.
34004124	3	70	theme	reagents	649:656	arg1	properties					610:619	poor mechanical properties	594:619	poor mechanical properties	594:619	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	3	70	theme	reagents	649:656	arg1	inhomogeneity					579:591	structural inhomogeneity	568:591	structural inhomogeneity	568:591	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	3	70	theme	reagents	649:656	arg1	utilization					624:634	utilization	624:634	utilization of cytotoxic reagents	624:656	However, conventional SF hydrogels may suffer from several major drawbacks, such as structural inhomogeneity, poor mechanical properties or utilization of cytotoxic reagents.
34004124	1	71	from	mori	178:181	arg1	polymer					196:202	a natural polymer	186:202	a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability	186:284	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	1	71	from	mori	178:181	arg1	SF					162:163	SF	162:163	SF	162:163	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	1	71	from	mori	178:181	arg1	fibroin					153:159	Silk fibroin	148:159	Silk fibroin (SF) from Bombyx mori	148:181	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	1	72	theme	Silk	148:151	arg1	polymer					196:202	a natural polymer	186:202	a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability	186:284	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	1	72	theme	Silk	148:151	arg1	SF					162:163	SF	162:163	SF	162:163	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	1	72	theme	Silk	148:151	arg1	fibroin					153:159	Silk fibroin	148:159	Silk fibroin (SF) from Bombyx mori	148:181	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
34004124	5	73	from	changes	1022:1028	arg1	behavior					1043:1050	toughness behavior	1033:1050	toughness behavior	1033:1050	The composite hydrogel not only demonstrated concentration-dependent stiffness variation but also exhibited time-dependent changes in toughness behavior.
34004124	5	74	theme	time-dependent	1007:1020	arg1	changes					1022:1028	time-dependent changes	1007:1028	time-dependent changes in toughness behavior	1007:1050	The composite hydrogel not only demonstrated concentration-dependent stiffness variation but also exhibited time-dependent changes in toughness behavior.
34004124	8	75	theme	unique	1589:1594	arg1	properties					1607:1616	unique mechanical properties	1589:1616	unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine	1589:1699	The combination of physical and enzymatic crosslinking strategies contributes to a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine.
34004124	5	76	theme	concentration-dependent	944:966	arg1	variation					978:986	concentration-dependent stiffness variation	944:986	concentration-dependent stiffness variation	944:986	The composite hydrogel not only demonstrated concentration-dependent stiffness variation but also exhibited time-dependent changes in toughness behavior.
34004124	7	77	theme	mechanical	1445:1454	arg1	properties					1456:1465	dynamically changing mechanical properties	1424:1465	dynamically changing mechanical properties	1424:1465	Finally, a three-dimensional (3 D) construct of the cell-laden hydrogel was fabricated, confirming that the composite hydrogel could provide a biocompatible microenvironment with dynamically changing mechanical properties.
34004124	2	78	theme	scaffolds	367:375	arg1	one					330:332	one	330:332	one	330:332	SF-based hydrogels have been identified as one of the most attractive candidate scaffolds for tissue engineering and can be fabricated through various physical or chemical crosslinking approaches.
34004124	2	78	theme	scaffolds	367:375	arg1	hydrogels					296:304	SF-based hydrogels	287:304	SF-based hydrogels	287:304	SF-based hydrogels have been identified as one of the most attractive candidate scaffolds for tissue engineering and can be fabricated through various physical or chemical crosslinking approaches.
34004124	2	78	theme	scaffolds	367:375	arg1	scaffolds					367:375	the most attractive candidate scaffolds	337:375	the most attractive candidate scaffolds for tissue engineering	337:398	SF-based hydrogels have been identified as one of the most attractive candidate scaffolds for tissue engineering and can be fabricated through various physical or chemical crosslinking approaches.
34004124	0	79	theme	mechanical	68:77	arg1	performance					79:89	mechanical performance	68:89	mechanical performance	68:89	Preparation of silk fibroin/hyaluronic acid hydrogels with enhanced mechanical performance by a combination of physical and enzymatic crosslinking.
34004124	8	80	theme	regenerative	1679:1690	arg1	medicine					1692:1699	regenerative medicine	1679:1699	regenerative medicine	1679:1699	The combination of physical and enzymatic crosslinking strategies contributes to a biocompatible composite hydrogel with unique mechanical properties that holds great potential for use in tissue engineering and regenerative medicine.
34004124	0	81	theme	silk	15:18	arg1	hydrogels					44:52	silk fibroin/hyaluronic acid hydrogels	15:52	silk fibroin/hyaluronic acid hydrogels	15:52	Preparation of silk fibroin/hyaluronic acid hydrogels with enhanced mechanical performance by a combination of physical and enzymatic crosslinking.
34004124	2	82	theme	candidate	357:365	arg1	scaffolds					367:375	the most attractive candidate scaffolds	337:375	the most attractive candidate scaffolds for tissue engineering	337:398	SF-based hydrogels have been identified as one of the most attractive candidate scaffolds for tissue engineering and can be fabricated through various physical or chemical crosslinking approaches.
34004124	7	83	theme	composite	1353:1361	arg1	hydrogel					1363:1370	the composite hydrogel	1349:1370	the composite hydrogel	1349:1370	Finally, a three-dimensional (3 D) construct of the cell-laden hydrogel was fabricated, confirming that the composite hydrogel could provide a biocompatible microenvironment with dynamically changing mechanical properties.
34004124	1	84	theme	low	239:241	arg1	immunogenicity					243:256	low immunogenicity	239:256	low immunogenicity	239:256	Silk fibroin (SF) from Bombyx mori is a natural polymer with exceptional biocompatibility, low immunogenicity, and ease of processability.
32350116	6	0	theme	SH3	1297:1299	arg1	domain					1301:1306	the SH3 domain	1293:1306	the SH3 domain	1293:1306	Furthermore, we found that although FUT8 is mainly localized to the Golgi, it also partially localizes to the cell surface in an SH3-dependent manner, indicating that the SH3 domain is also involved in FUT8 trafficking.
32350116	0	1	from	domain	8:13	arg1	FUT8					41:44	the fucosyltransferase FUT8	18:44	the fucosyltransferase FUT8	18:44	The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation.
32350116	3	2	theme	SH3	464:466	arg1	domain					469:474	an Src homology 3 (SH3) domain	445:474	an Src homology 3 (SH3) domain	445:474	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	7	3	theme	binding	1462:1468	arg1	I					1380:1380	ribophorin I	1369:1380	ribophorin I (RPN1)	1369:1387	Finally, we identified ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, as an SH3-dependent binding protein of FUT8.
32350116	7	3	theme	binding	1462:1468	arg1	protein					1470:1476	an SH3-dependent binding protein	1445:1476	an SH3-dependent binding protein of FUT8	1445:1484	Finally, we identified ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, as an SH3-dependent binding protein of FUT8.
32350116	9	4	theme	catalytic	1669:1677	arg1	activity					1679:1686	FUT8 catalytic activity	1664:1686	FUT8 catalytic activity	1664:1686	Our findings indicate that the SH3 domain critically controls FUT8 catalytic activity and localization and is required for binding by RPN1, which promotes FUT8 activity and core fucosylation.
32350116	1	5	theme	N-glycan	144:151	arg1	structure					153:161	an N-glycan structure	141:161	an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus	141:242	Core fucose is an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins.
32350116	1	5	theme	N-glycan	144:151	arg1	fucose					131:136	Core fucose	126:136	Core fucose	126:136	Core fucose is an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins.
32350116	5	6	theme	critical	1077:1084	arg1	residue					1086:1092	the critical residue	1073:1092	the critical residue for enzymatic activity of FUT8	1073:1123	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	6	theme	critical	1077:1084	arg1	His-535					1044:1050	His-535	1044:1050	His-535 in the SH3 domain	1044:1068	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	8	7	theme	FUT8	1587:1590	arg1	activity					1592:1599	FUT8 activity	1587:1599	FUT8 activity	1587:1599	RPN1 knockdown decreased both FUT8 activity and core fucose levels, indicating that RPN1 stimulates FUT8 activity.
32350116	8	8	theme	fucose	1540:1545	arg1	levels					1547:1552	core fucose levels	1535:1552	core fucose levels	1535:1552	RPN1 knockdown decreased both FUT8 activity and core fucose levels, indicating that RPN1 stimulates FUT8 activity.
32350116	5	9	theme	LC-electrospray	901:915	arg1	constructs					801:810	truncated FUT8 constructs	786:810	truncated FUT8 constructs	786:810	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	9	theme	LC-electrospray	901:915	arg1	analyses					931:938	LC-electrospray ionization MS analyses	901:938	LC-electrospray ionization MS analyses	901:938	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	7	10	theme	ribophorin	1369:1378	arg1	RPN1					1383:1386	RPN1	1383:1386	RPN1	1383:1386	Finally, we identified ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, as an SH3-dependent binding protein of FUT8.
32350116	7	10	theme	ribophorin	1369:1378	arg1	protein					1470:1476	an SH3-dependent binding protein	1445:1476	an SH3-dependent binding protein of FUT8	1445:1484	Finally, we identified ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, as an SH3-dependent binding protein of FUT8.
32350116	7	10	theme	ribophorin	1369:1378	arg1	I					1380:1380	ribophorin I	1369:1380	ribophorin I (RPN1)	1369:1387	Finally, we identified ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, as an SH3-dependent binding protein of FUT8.
32350116	7	10	theme	ribophorin	1369:1378	arg1	subunit					1392:1398	a subunit	1390:1398	a subunit of the oligosaccharyltransferase complex	1390:1439	Finally, we identified ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, as an SH3-dependent binding protein of FUT8.
32350116	8	11	theme	core	1535:1538	arg1	levels					1547:1552	core fucose levels	1535:1552	core fucose levels	1535:1552	RPN1 knockdown decreased both FUT8 activity and core fucose levels, indicating that RPN1 stimulates FUT8 activity.
32350116	5	12	theme	cell-surface	857:868	arg1	constructs					801:810	truncated FUT8 constructs	786:810	truncated FUT8 constructs	786:810	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	12	theme	cell-surface	857:868	arg1	biotinylation					870:882	cell-surface biotinylation	857:882	cell-surface biotinylation	857:882	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	3	13	theme	homology	452:459	arg1	domain					469:474	an Src homology 3 (SH3) domain	445:474	an Src homology 3 (SH3) domain	445:474	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	3	14	theme	Golgi	420:424	arg1	proteins					426:433	Golgi proteins	420:433	Golgi proteins	420:433	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	7	15	theme	SH3-dependent	1448:1460	arg1	I					1380:1380	ribophorin I	1369:1380	ribophorin I (RPN1)	1369:1387	Finally, we identified ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, as an SH3-dependent binding protein of FUT8.
32350116	7	15	theme	SH3-dependent	1448:1460	arg1	protein					1470:1476	an SH3-dependent binding protein	1445:1476	an SH3-dependent binding protein of FUT8	1445:1484	Finally, we identified ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, as an SH3-dependent binding protein of FUT8.
32350116	6	16	theme	FUT8	1328:1331	arg1	trafficking					1333:1343	FUT8 trafficking	1328:1343	FUT8 trafficking	1328:1343	Furthermore, we found that although FUT8 is mainly localized to the Golgi, it also partially localizes to the cell surface in an SH3-dependent manner, indicating that the SH3 domain is also involved in FUT8 trafficking.
32350116	5	17	dep	activity	993:1000	arg1	both					1002:1005	both	1002:1005	both	1002:1005	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	0	18	theme	SH3	4:6	arg1	domain					8:13	The SH3 domain	0:13	The SH3 domain in the fucosyltransferase FUT8	0:44	The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation.
32350116	0	18	theme	SH3	4:6	arg1	essential					93:101	essential	93:101	essential	93:101	The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation.
32350116	5	19	theme	SH3	1059:1061	arg1	domain					1063:1068	the SH3 domain	1055:1068	the SH3 domain	1055:1068	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	3	20	dep	side	398:401	arg1	the					386:388	the	386:388	the	386:388	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	3	21	theme	signal	513:518	arg1	molecules					533:541	cytosolic signal transduction molecules	503:541	cytosolic signal transduction molecules	503:541	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	5	22	theme	immunofluorescence	813:830	arg1	constructs					801:810	truncated FUT8 constructs	786:810	truncated FUT8 constructs	786:810	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	22	theme	immunofluorescence	813:830	arg1	staining					832:839	immunofluorescence staining	813:839	immunofluorescence staining	813:839	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	3	23	theme	transduction	520:531	arg1	molecules					533:541	cytosolic signal transduction molecules	503:541	cytosolic signal transduction molecules	503:541	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	3	24	located	found	494:498	arg1	molecules					533:541	cytosolic signal transduction molecules	503:541	cytosolic signal transduction molecules	503:541	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	3	24	located	found	494:498	arg2	domain					469:474	an Src homology 3 (SH3) domain	445:474	an Src homology 3 (SH3) domain	445:474	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	5	25	theme	FACS	842:845	arg1	constructs					801:810	truncated FUT8 constructs	786:810	truncated FUT8 constructs	786:810	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	25	theme	FACS	842:845	arg1	analysis					847:854	FACS analysis	842:854	FACS analysis	842:854	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	26	from	His-535	1044:1050	arg1	domain					1063:1068	the SH3 domain	1055:1068	the SH3 domain	1055:1068	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	27	theme	FUT8	1120:1123	arg1	activity					1108:1115	enzymatic activity	1098:1115	enzymatic activity of FUT8	1098:1123	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	6	28	theme	SH3-dependent	1255:1267	arg1	manner					1269:1274	an SH3-dependent manner	1252:1274	an SH3-dependent manner	1252:1274	Furthermore, we found that although FUT8 is mainly localized to the Golgi, it also partially localizes to the cell surface in an SH3-dependent manner, indicating that the SH3 domain is also involved in FUT8 trafficking.
32350116	5	29	theme	MS	928:929	arg1	constructs					801:810	truncated FUT8 constructs	786:810	truncated FUT8 constructs	786:810	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	29	theme	MS	928:929	arg1	analyses					931:938	LC-electrospray ionization MS analyses	901:938	LC-electrospray ionization MS analyses	901:938	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	30	theme	truncated	786:794	arg1	proteomics					885:894	proteomics	885:894	proteomics	885:894	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	30	theme	truncated	786:794	arg1	constructs					801:810	truncated FUT8 constructs	786:810	truncated FUT8 constructs	786:810	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	30	theme	truncated	786:794	arg1	analysis					847:854	FACS analysis	842:854	FACS analysis	842:854	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	30	theme	truncated	786:794	arg1	biotinylation					870:882	cell-surface biotinylation	857:882	cell-surface biotinylation	857:882	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	30	theme	truncated	786:794	arg1	staining					832:839	immunofluorescence staining	813:839	immunofluorescence staining	813:839	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	30	theme	truncated	786:794	arg1	analyses					931:938	LC-electrospray ionization MS analyses	901:938	LC-electrospray ionization MS analyses	901:938	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	31	theme	ionization	917:926	arg1	constructs					801:810	truncated FUT8 constructs	786:810	truncated FUT8 constructs	786:810	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	31	theme	ionization	917:926	arg1	analyses					931:938	LC-electrospray ionization MS analyses	901:938	LC-electrospray ionization MS analyses	901:938	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	0	32	theme	core	107:110	arg1	fucosylation					112:123	core fucosylation	107:123	core fucosylation	107:123	The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation.
32350116	3	33	theme	cytosolic	503:511	arg1	molecules					533:541	cytosolic signal transduction molecules	503:541	cytosolic signal transduction molecules	503:541	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	5	34	theme	FUT8	796:799	arg1	proteomics					885:894	proteomics	885:894	proteomics	885:894	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	34	theme	FUT8	796:799	arg1	constructs					801:810	truncated FUT8 constructs	786:810	truncated FUT8 constructs	786:810	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	34	theme	FUT8	796:799	arg1	analysis					847:854	FACS analysis	842:854	FACS analysis	842:854	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	34	theme	FUT8	796:799	arg1	biotinylation					870:882	cell-surface biotinylation	857:882	cell-surface biotinylation	857:882	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	34	theme	FUT8	796:799	arg1	staining					832:839	immunofluorescence staining	813:839	immunofluorescence staining	813:839	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	34	theme	FUT8	796:799	arg1	analyses					931:938	LC-electrospray ionization MS analyses	901:938	LC-electrospray ionization MS analyses	901:938	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	0	35	theme	fucosyltransferase	22:39	arg1	FUT8					41:44	the fucosyltransferase FUT8	18:44	the fucosyltransferase FUT8	18:44	The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation.
32350116	1	36	theme	various	286:292	arg1	glycoproteins					294:306	various glycoproteins	286:306	various glycoproteins	286:306	Core fucose is an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins.
32350116	8	37	theme	RPN1	1487:1490	arg1	knockdown					1492:1500	RPN1 knockdown	1487:1500	RPN1 knockdown	1487:1500	RPN1 knockdown decreased both FUT8 activity and core fucose levels, indicating that RPN1 stimulates FUT8 activity.
32350116	4	38	theme	SH3	624:626	arg1	domain					628:633	the SH3 domain	620:633	the SH3 domain	620:633	However, the SH3 domain has not been identified in other glycosyltransferases, suggesting that FUT8's functions are selectively regulated by this domain.
32350116	1	39	theme	glycoproteins	294:306	arg1	functions					273:281	the functions	269:281	the functions of various glycoproteins	269:306	Core fucose is an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins.
32350116	7	40	theme	oligosaccharyltransferase	1407:1431	arg1	complex					1433:1439	the oligosaccharyltransferase complex	1403:1439	the oligosaccharyltransferase complex	1403:1439	Finally, we identified ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, as an SH3-dependent binding protein of FUT8.
32350116	7	41	theme	complex	1433:1439	arg1	I					1380:1380	ribophorin I	1369:1380	ribophorin I (RPN1)	1369:1387	Finally, we identified ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, as an SH3-dependent binding protein of FUT8.
32350116	7	41	theme	complex	1433:1439	arg1	subunit					1392:1398	a subunit	1390:1398	a subunit of the oligosaccharyltransferase complex	1390:1439	Finally, we identified ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, as an SH3-dependent binding protein of FUT8.
32350116	6	42	theme	cell	1236:1239	arg1	surface					1241:1247	the cell surface	1232:1247	the cell surface	1232:1247	Furthermore, we found that although FUT8 is mainly localized to the Golgi, it also partially localizes to the cell surface in an SH3-dependent manner, indicating that the SH3 domain is also involved in FUT8 trafficking.
32350116	3	43	contain	has	441:443	arg1	FUT8					436:439	FUT8	436:439	FUT8	436:439	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	3	43	contain	has	441:443	arg2	domain					469:474	an Src homology 3 (SH3) domain	445:474	an Src homology 3 (SH3) domain	445:474	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	5	44	theme	FUT8	988:991	arg1	activity					993:1000	FUT8 activity	988:1000	FUT8 activity	988:1000	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	3	45	theme	luminal	390:396	arg1	side					398:401	luminal side	390:401	luminal side	390:401	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	5	46	theme	enzymatic	1098:1106	arg1	activity					1108:1115	enzymatic activity	1098:1115	enzymatic activity of FUT8	1098:1123	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	4	47	theme	other	662:666	arg1	glycosyltransferases					668:687	other glycosyltransferases	662:687	other glycosyltransferases	662:687	However, the SH3 domain has not been identified in other glycosyltransferases, suggesting that FUT8's functions are selectively regulated by this domain.
32350116	9	48	theme	SH3	1633:1635	arg1	domain					1637:1642	the SH3 domain	1629:1642	the SH3 domain	1629:1642	Our findings indicate that the SH3 domain critically controls FUT8 catalytic activity and localization and is required for binding by RPN1, which promotes FUT8 activity and core fucosylation.
32350116	2	49	theme	FUT8	322:325	arg1	activity					327:334	FUT8 activity	322:334	FUT8 activity	322:334	However, how FUT8 activity is regulated in cells remains largely unclear.
32350116	9	50	theme	FUT8	1757:1760	arg1	activity					1762:1769	FUT8 activity	1757:1769	FUT8 activity	1757:1769	Our findings indicate that the SH3 domain critically controls FUT8 catalytic activity and localization and is required for binding by RPN1, which promotes FUT8 activity and core fucosylation.
32350116	9	51	theme	FUT8	1664:1667	arg1	activity					1679:1686	FUT8 catalytic activity	1664:1686	FUT8 catalytic activity	1664:1686	Our findings indicate that the SH3 domain critically controls FUT8 catalytic activity and localization and is required for binding by RPN1, which promotes FUT8 activity and core fucosylation.
32350116	5	52	theme	SH3	960:962	arg1	domain					964:969	the SH3 domain	956:969	the SH3 domain	956:969	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	5	52	theme	SH3	960:962	arg1	essential					974:982	essential	974:982	essential	974:982	In this study, using truncated FUT8 constructs, immunofluorescence staining, FACS analysis, cell-surface biotinylation, proteomics, and LC-electrospray ionization MS analyses, we reveal that the SH3 domain is essential for FUT8 activity both in cells and in vitro and identified His-535 in the SH3 domain as the critical residue for enzymatic activity of FUT8.
32350116	1	53	theme	Core	126:129	arg1	structure					153:161	an N-glycan structure	141:161	an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus	141:242	Core fucose is an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins.
32350116	1	53	theme	Core	126:129	arg1	fucose					131:136	Core fucose	126:136	Core fucose	126:136	Core fucose is an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins.
32350116	3	54	theme	Src	448:450	arg1	domain					469:474	an Src homology 3 (SH3) domain	445:474	an Src homology 3 (SH3) domain	445:474	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	3	55	theme	protein-protein	566:580	arg1	interactions					582:593	protein-protein interactions	566:593	protein-protein interactions	566:593	At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol.
32350116	1	56	gly	glycoproteins	294:306	arg1	glycoproteins					294:306	various glycoproteins	286:306	various glycoproteins	286:306	Core fucose is an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins.
32350116	8	57	theme	FUT8	1517:1520	arg1	activity					1522:1529	FUT8 activity	1517:1529	FUT8 activity	1517:1529	RPN1 knockdown decreased both FUT8 activity and core fucose levels, indicating that RPN1 stimulates FUT8 activity.
32350116	0	58	theme	FUT8	55:58	arg1	activity					60:67	FUT8 activity	55:67	FUT8 activity	55:67	The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation.
32350116	7	59	theme	FUT8	1481:1484	arg1	I					1380:1380	ribophorin I	1369:1380	ribophorin I (RPN1)	1369:1387	Finally, we identified ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, as an SH3-dependent binding protein of FUT8.
32350116	7	59	theme	FUT8	1481:1484	arg1	protein					1470:1476	an SH3-dependent binding protein	1445:1476	an SH3-dependent binding protein of FUT8	1445:1484	Finally, we identified ribophorin I (RPN1), a subunit of the oligosaccharyltransferase complex, as an SH3-dependent binding protein of FUT8.
32350116	9	60	theme	core	1775:1778	arg1	fucosylation					1780:1791	core fucosylation	1775:1791	core fucosylation	1775:1791	Our findings indicate that the SH3 domain critically controls FUT8 catalytic activity and localization and is required for binding by RPN1, which promotes FUT8 activity and core fucosylation.
32350116	1	61	theme	Golgi	228:232	arg1	apparatus					234:242	the Golgi apparatus	224:242	the Golgi apparatus	224:242	Core fucose is an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins.
34126538	2	0	theme	wastewater	448:457	arg1	treatment					459:467	wastewater treatment	448:467	wastewater treatment containing inorganic salts and E.Coli	448:505	The synthesized membrane was tested in wastewater treatment containing inorganic salts and E.Coli.
34126538	1	1	theme	piperazine	319:328	arg1	polymerization					301:314	interfacial polymerization	289:314	interfacial polymerization of piperazine with trimesoyl chloride	289:352	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	3	2	theme	water	783:787	arg1	flux					789:792	water flux	783:792	water flux	783:792	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	1	3	theme	trimesoyl	335:343	arg1	chloride					345:352	trimesoyl chloride	335:352	trimesoyl chloride	335:352	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	1	4	theme	sheet	201:205	arg1	membrane					232:239	flat sheet composite nanofiltration membrane	196:239	flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride	196:352	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	10	5	dep	220 L m-2	1588:1596	arg1	up					1582:1583	up	1582:1583	up	1582:1583	The model feed solution of E. coli after passing through the membrane achieved an E. coli rejection (99%) with water flux up to 220 L m-2.
34126538	1	6	theme	nanofiltration	217:230	arg1	membrane					232:239	flat sheet composite nanofiltration membrane	196:239	flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride	196:352	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	4	7	with	%	963:963	arg1	flux					1001:1004	an average water flux	984:1004	an average water flux up to 214 ± 10 L m⁻2	984:1025	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	3	8	from	flux	789:792	arg1	the					819:821	the	819:821	the	819:821	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	8	9	from	system	1297:1302	arg1	feed					1311:1314	the feed	1307:1314	the feed	1307:1314	The quaternary ion system in the feed resulted in an average water flux up to 198 ± 12 L m⁻2.
34126538	6	10	theme	ternary	1195:1201	arg1	solution					1215:1222	ternary electrolyte solution	1195:1222	ternary electrolyte solution with an average water flux up to 211 ± 10 L m-2	1195:1270	Similarly, the rejection for K1+, Mg2+, Cl1- and SO42- was noted to be 33, 94, 97, and 99%, respectively, for ternary electrolyte solution with an average water flux up to 211 ± 10 L m-2.
34126538	3	11	theme	electrolyte	681:691	arg1	solution					693:700	quaternary electrolyte solution	670:700	quaternary electrolyte solution of KCl, MgCl2, and MgSO4	670:725	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	1	12	theme	chitosan	258:265	arg1	nanoparticles					267:279	chitosan nanoparticles	258:279	chitosan nanoparticles	258:279	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	4	13	theme	SO42-	916:920	arg1	%					963:963	81, 28, 87, 96, and 98%	941:963	81, 28, 87, 96, and 98%	941:963	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	4	13	theme	SO42-	916:920	arg1	rejection					876:884	The rejection	872:884	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42-	872:920	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	8	14	theme	average	1331:1337	arg1	flux					1345:1348	an average water flux	1328:1348	an average water flux up to 198 ± 12 L m⁻2	1328:1369	The quaternary ion system in the feed resulted in an average water flux up to 198 ± 12 L m⁻2.
34126538	10	15	theme	E.	1542:1543	arg1	rejection					1550:1558	an E. coli rejection	1539:1558	an E. coli rejection (99%) with water flux up to 220 L m-2	1539:1596	The model feed solution of E. coli after passing through the membrane achieved an E. coli rejection (99%) with water flux up to 220 L m-2.
34126538	10	15	theme	E.	1542:1543	arg1	%					1563:1563	99%	1561:1563	99%	1561:1563	The model feed solution of E. coli after passing through the membrane achieved an E. coli rejection (99%) with water flux up to 220 L m-2.
34126538	5	16	theme	electrolyte	1063:1073	arg1	solution					1075:1082	the binary electrolyte solution	1052:1082	the binary electrolyte solution	1052:1082	hr⁻1 in the permeate for the binary electrolyte solution.
34126538	1	17	theme	experimental	166:177	arg1	investigation					179:191	the experimental investigation	162:191	the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates	162:406	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	10	18	dep	E.	1542:1543	arg1	coli					1545:1548	coli	1545:1548	coli	1545:1548	The model feed solution of E. coli after passing through the membrane achieved an E. coli rejection (99%) with water flux up to 220 L m-2.
34126538	1	19	from	investigation	179:191	arg1	substrates					397:406	polyethersulfone/sulfonated polysulfone substrates	357:406	polyethersulfone/sulfonated polysulfone substrates	357:406	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	3	20	contain	containing	607:616	arg2	combination					620:630	a combination	618:630	a combination of MgCl2 and MgSO4, KCl and MgCl2	618:664	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	20	contain	containing	607:616	arg2	solution					693:700	quaternary electrolyte solution	670:700	quaternary electrolyte solution of KCl, MgCl2, and MgSO4	670:725	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	20	contain	containing	607:616	arg1	solution					597:604	ternary electrolyte solution	577:604	ternary electrolyte solution	577:604	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	20	contain	containing	607:616	arg1	solution					534:541	Single binary electrolyte solution	508:541	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4	508:574	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	9	21	with	hr⁻1	1371:1374	arg1	rejection					1385:1393	the rejection	1381:1393	the rejection of K+, Mg+2, Cl- and SO4-2 as 35, 87, 96, and 99%, respectively	1381:1457	hr⁻1 with the rejection of K+, Mg+2, Cl- and SO4-2 as 35, 87, 96, and 99%, respectively.
34126538	0	22	theme	film	103:106	arg1	membrane					133:140	thin film composite nanofiltration membrane	98:140	thin film composite nanofiltration membrane	98:140	Multi-ionic electrolytes and E.coli removal from wastewater using chitosan-based in-situ mediated thin film composite nanofiltration membrane.
34126538	3	23	dep	the	819:821	arg1	permeate					823:830	permeate	823:830	permeate	823:830	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	9	24	theme	K+	1398:1399	arg1	rejection					1385:1393	the rejection	1381:1393	the rejection of K+, Mg+2, Cl- and SO4-2 as 35, 87, 96, and 99%, respectively	1381:1457	hr⁻1 with the rejection of K+, Mg+2, Cl- and SO4-2 as 35, 87, 96, and 99%, respectively.
34126538	0	25	from	wastewater	49:58	arg1	electrolytes					12:23	Multi-ionic electrolytes	0:23	Multi-ionic electrolytes	0:23	Multi-ionic electrolytes and E.coli removal from wastewater using chitosan-based in-situ mediated thin film composite nanofiltration membrane.
34126538	0	25	from	wastewater	49:58	arg1	removal					36:42	E.coli removal	29:42	E.coli removal from wastewater	29:58	Multi-ionic electrolytes and E.coli removal from wastewater using chitosan-based in-situ mediated thin film composite nanofiltration membrane.
34126538	0	26	theme	nanofiltration	118:131	arg1	membrane					133:140	thin film composite nanofiltration membrane	98:140	thin film composite nanofiltration membrane	98:140	Multi-ionic electrolytes and E.coli removal from wastewater using chitosan-based in-situ mediated thin film composite nanofiltration membrane.
34126538	2	27	contain	containing	469:478	arg1	treatment					459:467	wastewater treatment	448:467	wastewater treatment containing inorganic salts and E.Coli	448:505	The synthesized membrane was tested in wastewater treatment containing inorganic salts and E.Coli.
34126538	2	27	contain	containing	469:478	arg2	E.Coli					500:505	E.Coli	500:505	E.Coli	500:505	The synthesized membrane was tested in wastewater treatment containing inorganic salts and E.Coli.
34126538	2	27	contain	containing	469:478	arg2	salts					490:494	inorganic salts	480:494	inorganic salts	480:494	The synthesized membrane was tested in wastewater treatment containing inorganic salts and E.Coli.
34126538	9	28	theme	Mg+2	1402:1405	arg1	rejection					1385:1393	the rejection	1381:1393	the rejection of K+, Mg+2, Cl- and SO4-2 as 35, 87, 96, and 99%, respectively	1381:1457	hr⁻1 with the rejection of K+, Mg+2, Cl- and SO4-2 as 35, 87, 96, and 99%, respectively.
34126538	4	29	theme	average	987:993	arg1	flux					1001:1004	an average water flux	984:1004	an average water flux up to 214 ± 10 L m⁻2	984:1025	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	3	30	from	rejection	806:814	arg1	the					819:821	the	819:821	the	819:821	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	0	31	theme	Multi-ionic	0:10	arg1	electrolytes					12:23	Multi-ionic electrolytes	0:23	Multi-ionic electrolytes	0:23	Multi-ionic electrolytes and E.coli removal from wastewater using chitosan-based in-situ mediated thin film composite nanofiltration membrane.
34126538	9	32	theme	Cl-	1408:1410	arg1	rejection					1385:1393	the rejection	1381:1393	the rejection of K+, Mg+2, Cl- and SO4-2 as 35, 87, 96, and 99%, respectively	1381:1457	hr⁻1 with the rejection of K+, Mg+2, Cl- and SO4-2 as 35, 87, 96, and 99%, respectively.
34126538	1	33	theme	polyethersulfone/sulfonated	357:383	arg1	substrates					397:406	polyethersulfone/sulfonated polysulfone substrates	357:406	polyethersulfone/sulfonated polysulfone substrates	357:406	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	9	34	theme	SO4-2	1416:1420	arg1	rejection					1385:1393	the rejection	1381:1393	the rejection of K+, Mg+2, Cl- and SO4-2 as 35, 87, 96, and 99%, respectively	1381:1457	hr⁻1 with the rejection of K+, Mg+2, Cl- and SO4-2 as 35, 87, 96, and 99%, respectively.
34126538	3	35	theme	electrolyte	522:532	arg1	solution					597:604	ternary electrolyte solution	577:604	ternary electrolyte solution	577:604	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	35	theme	electrolyte	522:532	arg1	solution					534:541	Single binary electrolyte solution	508:541	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4	508:574	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	36	theme	MgSO4	721:725	arg1	combination					620:630	a combination	618:630	a combination of MgCl2 and MgSO4, KCl and MgCl2	618:664	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	36	theme	MgSO4	721:725	arg1	solution					693:700	quaternary electrolyte solution	670:700	quaternary electrolyte solution of KCl, MgCl2, and MgSO4	670:725	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	37	theme	Single	508:513	arg1	solution					597:604	ternary electrolyte solution	577:604	ternary electrolyte solution	577:604	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	37	theme	Single	508:513	arg1	solution					534:541	Single binary electrolyte solution	508:541	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4	508:574	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	8	38	theme	quaternary	1282:1291	arg1	system					1297:1302	The quaternary ion system	1278:1302	The quaternary ion system in the feed	1278:1314	The quaternary ion system in the feed resulted in an average water flux up to 198 ± 12 L m⁻2.
34126538	10	39	theme	coli	1490:1493	arg1	solution					1475:1482	solution	1475:1482	solution of E. coli	1475:1493	The model feed solution of E. coli after passing through the membrane achieved an E. coli rejection (99%) with water flux up to 220 L m-2.
34126538	3	40	theme	Na2SO4	569:574	arg1	solution					597:604	ternary electrolyte solution	577:604	ternary electrolyte solution	577:604	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	40	theme	Na2SO4	569:574	arg1	solution					534:541	Single binary electrolyte solution	508:541	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4	508:574	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	5	41	dep	the	1035:1037	arg1	permeate					1039:1046	permeate	1039:1046	permeate	1039:1046	hr⁻1 in the permeate for the binary electrolyte solution.
34126538	2	42	theme	inorganic	480:488	arg1	salts					490:494	inorganic salts	480:494	inorganic salts	480:494	The synthesized membrane was tested in wastewater treatment containing inorganic salts and E.Coli.
34126538	1	43	theme	interfacial	289:299	arg1	polymerization					301:314	interfacial polymerization	289:314	interfacial polymerization of piperazine with trimesoyl chloride	289:352	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	4	44	theme	Mg2+	900:903	arg1	%					963:963	81, 28, 87, 96, and 98%	941:963	81, 28, 87, 96, and 98%	941:963	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	4	44	theme	Mg2+	900:903	arg1	rejection					876:884	The rejection	872:884	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42-	872:920	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	3	45	theme	crossflow	751:759	arg1	cell					770:773	crossflow membrane cell	751:773	crossflow membrane cell	751:773	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	46	theme	MgCl2	635:639	arg1	combination					620:630	a combination	618:630	a combination of MgCl2 and MgSO4, KCl and MgCl2	618:664	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	46	theme	MgCl2	635:639	arg1	solution					693:700	quaternary electrolyte solution	670:700	quaternary electrolyte solution of KCl, MgCl2, and MgSO4	670:725	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	8	47	dep	198 ± 12 L	1356:1365	arg1	to					1353:1354	to	1353:1354	to	1353:1354	The quaternary ion system in the feed resulted in an average water flux up to 198 ± 12 L m⁻2.
34126538	3	48	theme	KCl	652:654	arg1	combination					620:630	a combination	618:630	a combination of MgCl2 and MgSO4, KCl and MgCl2	618:664	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	48	theme	KCl	652:654	arg1	solution					693:700	quaternary electrolyte solution	670:700	quaternary electrolyte solution of KCl, MgCl2, and MgSO4	670:725	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	4	49	theme	Cl1-	906:909	arg1	%					963:963	81, 28, 87, 96, and 98%	941:963	81, 28, 87, 96, and 98%	941:963	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	4	49	theme	Cl1-	906:909	arg1	rejection					876:884	The rejection	872:884	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42-	872:920	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	3	50	theme	ternary	577:583	arg1	solution					597:604	ternary electrolyte solution	577:604	ternary electrolyte solution	577:604	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	50	theme	ternary	577:583	arg1	solution					534:541	Single binary electrolyte solution	508:541	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4	508:574	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	4	51	dep	flux	1001:1004	arg1	m⁻2					1023:1025	up to 214 ± 10 L m⁻2	1006:1025	an average water flux up to 214 ± 10 L m⁻2	984:1025	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	1	52	theme	flat	196:199	arg1	sheet					201:205	flat sheet	196:205	flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride	196:352	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	4	53	theme	Na1+	889:892	arg1	%					963:963	81, 28, 87, 96, and 98%	941:963	81, 28, 87, 96, and 98%	941:963	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	4	53	theme	Na1+	889:892	arg1	rejection					876:884	The rejection	872:884	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42-	872:920	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	2	54	theme	synthesized	413:423	arg1	membrane					425:432	The synthesized membrane	409:432	The synthesized membrane	409:432	The synthesized membrane was tested in wastewater treatment containing inorganic salts and E.Coli.
34126538	6	55	with	solution	1215:1222	arg1	flux					1246:1249	an average water flux	1229:1249	an average water flux up to 211 ± 10 L m-2	1229:1270	Similarly, the rejection for K1+, Mg2+, Cl1- and SO42- was noted to be 33, 94, 97, and 99%, respectively, for ternary electrolyte solution with an average water flux up to 211 ± 10 L m-2.
34126538	1	56	theme	composite	207:215	arg1	membrane					232:239	flat sheet composite nanofiltration membrane	196:239	flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride	196:352	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	4	57	theme	K1+	895:897	arg1	%					963:963	81, 28, 87, 96, and 98%	941:963	81, 28, 87, 96, and 98%	941:963	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	4	57	theme	K1+	895:897	arg1	rejection					876:884	The rejection	872:884	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42-	872:920	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	3	58	theme	MgSO4	645:649	arg1	combination					620:630	a combination	618:630	a combination of MgCl2 and MgSO4, KCl and MgCl2	618:664	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	58	theme	MgSO4	645:649	arg1	solution					693:700	quaternary electrolyte solution	670:700	quaternary electrolyte solution of KCl, MgCl2, and MgSO4	670:725	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	1	59	theme	membrane	232:239	arg1	investigation					179:191	the experimental investigation	162:191	the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates	162:406	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	3	60	theme	species	798:804	arg1	rejection					806:814	species rejection	798:814	species rejection	798:814	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	6	61	theme	electrolyte	1203:1213	arg1	solution					1215:1222	ternary electrolyte solution	1195:1222	ternary electrolyte solution with an average water flux up to 211 ± 10 L m-2	1195:1270	Similarly, the rejection for K1+, Mg2+, Cl1- and SO42- was noted to be 33, 94, 97, and 99%, respectively, for ternary electrolyte solution with an average water flux up to 211 ± 10 L m-2.
34126538	10	62	theme	water	1571:1575	arg1	flux					1577:1580	water flux	1571:1580	water flux	1571:1580	The model feed solution of E. coli after passing through the membrane achieved an E. coli rejection (99%) with water flux up to 220 L m-2.
34126538	3	63	theme	operating	838:846	arg1	pressure					848:855	operating pressure	838:855	operating pressure	838:855	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	64	dep	0.5 MPa	863:869	arg1	up					857:858	up	857:858	up	857:858	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	65	theme	MgCl2	660:664	arg1	combination					620:630	a combination	618:630	a combination of MgCl2 and MgSO4, KCl and MgCl2	618:664	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	65	theme	MgCl2	660:664	arg1	solution					693:700	quaternary electrolyte solution	670:700	quaternary electrolyte solution of KCl, MgCl2, and MgSO4	670:725	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	8	66	theme	water	1339:1343	arg1	flux					1345:1348	an average water flux	1328:1348	an average water flux up to 198 ± 12 L m⁻2	1328:1369	The quaternary ion system in the feed resulted in an average water flux up to 198 ± 12 L m⁻2.
34126538	3	67	theme	KCl	705:707	arg1	combination					620:630	a combination	618:630	a combination of MgCl2 and MgSO4, KCl and MgCl2	618:664	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	67	theme	KCl	705:707	arg1	solution					693:700	quaternary electrolyte solution	670:700	quaternary electrolyte solution of KCl, MgCl2, and MgSO4	670:725	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	6	68	theme	water	1240:1244	arg1	flux					1246:1249	an average water flux	1229:1249	an average water flux up to 211 ± 10 L m-2	1229:1270	Similarly, the rejection for K1+, Mg2+, Cl1- and SO42- was noted to be 33, 94, 97, and 99%, respectively, for ternary electrolyte solution with an average water flux up to 211 ± 10 L m-2.
34126538	0	69	theme	thin	98:101	arg1	film					103:106	thin film	98:106	thin film composite nanofiltration membrane	98:140	Multi-ionic electrolytes and E.coli removal from wastewater using chitosan-based in-situ mediated thin film composite nanofiltration membrane.
34126538	10	70	with	rejection	1550:1558	arg1	flux					1577:1580	water flux	1571:1580	water flux	1571:1580	The model feed solution of E. coli after passing through the membrane achieved an E. coli rejection (99%) with water flux up to 220 L m-2.
34126538	0	71	theme	composite	108:116	arg1	membrane					133:140	thin film composite nanofiltration membrane	98:140	thin film composite nanofiltration membrane	98:140	Multi-ionic electrolytes and E.coli removal from wastewater using chitosan-based in-situ mediated thin film composite nanofiltration membrane.
34126538	4	72	dep	214 ± 10 L	1012:1021	arg1	to					1009:1010	to	1009:1010	to	1009:1010	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	6	73	theme	average	1232:1238	arg1	flux					1246:1249	an average water flux	1229:1249	an average water flux up to 211 ± 10 L m-2	1229:1270	Similarly, the rejection for K1+, Mg2+, Cl1- and SO42- was noted to be 33, 94, 97, and 99%, respectively, for ternary electrolyte solution with an average water flux up to 211 ± 10 L m-2.
34126538	3	74	theme	MgCl2	551:555	arg1	solution					597:604	ternary electrolyte solution	577:604	ternary electrolyte solution	577:604	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	74	theme	MgCl2	551:555	arg1	solution					534:541	Single binary electrolyte solution	508:541	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4	508:574	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	5	75	theme	binary	1056:1061	arg1	solution					1075:1082	the binary electrolyte solution	1052:1082	the binary electrolyte solution	1052:1082	hr⁻1 in the permeate for the binary electrolyte solution.
34126538	3	76	theme	KCl	546:548	arg1	solution					597:604	ternary electrolyte solution	577:604	ternary electrolyte solution	577:604	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	76	theme	KCl	546:548	arg1	solution					534:541	Single binary electrolyte solution	508:541	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4	508:574	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	0	77	theme	E.coli	29:34	arg1	removal					36:42	E.coli removal	29:42	E.coli removal from wastewater	29:58	Multi-ionic electrolytes and E.coli removal from wastewater using chitosan-based in-situ mediated thin film composite nanofiltration membrane.
34126538	8	78	dep	flux	1345:1348	arg1	m⁻2					1367:1369	up to 198 ± 12 L m⁻2	1350:1369	an average water flux up to 198 ± 12 L m⁻2	1328:1369	The quaternary ion system in the feed resulted in an average water flux up to 198 ± 12 L m⁻2.
34126538	3	79	theme	quaternary	670:679	arg1	solution					693:700	quaternary electrolyte solution	670:700	quaternary electrolyte solution of KCl, MgCl2, and MgSO4	670:725	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	4	80	theme	water	995:999	arg1	flux					1001:1004	an average water flux	984:1004	an average water flux up to 214 ± 10 L m⁻2	984:1025	The rejection of Na1+, K1+, Mg2+, Cl1-, and SO42- was observed to be 81, 28, 87, 96, and 98%, respectively with an average water flux up to 214 ± 10 L m⁻2.
34126538	1	81	theme	polysulfone	385:395	arg1	substrates					397:406	polyethersulfone/sulfonated polysulfone substrates	357:406	polyethersulfone/sulfonated polysulfone substrates	357:406	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	3	82	theme	MgCl2	710:714	arg1	combination					620:630	a combination	618:630	a combination of MgCl2 and MgSO4, KCl and MgCl2	618:664	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	82	theme	MgCl2	710:714	arg1	solution					693:700	quaternary electrolyte solution	670:700	quaternary electrolyte solution of KCl, MgCl2, and MgSO4	670:725	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	83	theme	MgSO4	558:562	arg1	solution					597:604	ternary electrolyte solution	577:604	ternary electrolyte solution	577:604	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	83	theme	MgSO4	558:562	arg1	solution					534:541	Single binary electrolyte solution	508:541	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4	508:574	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	84	theme	binary	515:520	arg1	solution					597:604	ternary electrolyte solution	577:604	ternary electrolyte solution	577:604	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	84	theme	binary	515:520	arg1	solution					534:541	Single binary electrolyte solution	508:541	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4	508:574	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	85	theme	electrolyte	585:595	arg1	solution					597:604	ternary electrolyte solution	577:604	ternary electrolyte solution	577:604	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	85	theme	electrolyte	585:595	arg1	solution					534:541	Single binary electrolyte solution	508:541	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4	508:574	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	3	86	dep	flux	789:792	arg1	the					779:781	the	779:781	the	779:781	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
34126538	8	87	theme	ion	1293:1295	arg1	system					1297:1302	The quaternary ion system	1278:1302	The quaternary ion system in the feed	1278:1314	The quaternary ion system in the feed resulted in an average water flux up to 198 ± 12 L m⁻2.
34126538	1	88	with	polymerization	301:314	arg1	chloride					345:352	trimesoyl chloride	335:352	trimesoyl chloride	335:352	This work presents the experimental investigation of flat sheet composite nanofiltration membrane synthesized with chitosan nanoparticles through interfacial polymerization of piperazine with trimesoyl chloride on polyethersulfone/sulfonated polysulfone substrates.
34126538	3	89	theme	membrane	761:768	arg1	cell					770:773	crossflow membrane cell	751:773	crossflow membrane cell	751:773	Single binary electrolyte solution of KCl, MgCl2, MgSO4, and Na2SO4, ternary electrolyte solution, containing a combination of MgCl2 and MgSO4, KCl and MgCl2 and quaternary electrolyte solution of KCl, MgCl2, and MgSO4 as feed were treated in crossflow membrane cell for the water flux and species rejection in the permeate under operating pressure up to 0.5 MPa.
32462243	12	0	theme	nanoparticle	2117:2128	arg1	efficacy					2097:2104	• Antimicrobial efficacy	2081:2104	• Antimicrobial efficacy of bimetal nanoparticle	2081:2128	• Antimicrobial efficacy of bimetal nanoparticle parallels Ag+ions release.
32462243	6	1	theme	high-Fe/Ag-EPS	1029:1042	arg1	NPs					1044:1046	high-Fe/Ag-EPS NPs	1029:1046	high-Fe/Ag-EPS NPs	1029:1046	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	3	2	theme	carbon	477:482	arg1	source					484:489	sole carbon source	472:489	sole carbon source	472:489	K. oxytoca DSM 29614 was cultivated in a defined growth medium-containing citrate (as sole carbon source) and supplemented with Ag+ and either low or high Fe(III) concentration.
32462243	11	3	theme	•	2002:2002	arg1	assay					2037:2041	• Phycoerythrin fluorescence-based assay	2002:2041	• Phycoerythrin fluorescence-based assay	2002:2041	• Phycoerythrin fluorescence-based assay was developed to determine Ag+release.
32462243	6	4	theme	ad	1134:1135	arg1	assay					1186:1190	a novel ad hoc established phycoerythrin fluorescence-based assay	1126:1190	a novel ad hoc established phycoerythrin fluorescence-based assay	1126:1190	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	3	5	theme	sole	472:475	arg1	source					484:489	sole carbon source	472:489	sole carbon source	472:489	K. oxytoca DSM 29614 was cultivated in a defined growth medium-containing citrate (as sole carbon source) and supplemented with Ag+ and either low or high Fe(III) concentration.
32462243	12	6	theme	Antimicrobial	2083:2095	arg1	efficacy					2097:2104	• Antimicrobial efficacy	2081:2104	• Antimicrobial efficacy of bimetal nanoparticle	2081:2128	• Antimicrobial efficacy of bimetal nanoparticle parallels Ag+ions release.
32462243	9	7	theme	oxytoca	1700:1706	arg1	29614					1712:1716	K. oxytoca DSM 29614	1697:1716	K. oxytoca DSM 29614	1697:1716	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	4	8	theme	transmission	601:612	arg1	analysis					591:598	elemental analysis	581:598	elemental analysis	581:598	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	4	8	theme	transmission	601:612	arg1	microscopy					636:645	transmission and scanning electron microscopy	601:645	microscopy	636:645	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	5	9	theme	NPs	824:826	arg1	yield					800:804	The production yield	785:804	The production yield of high-Fe/Ag-EPS NPs	785:826	The production yield of high-Fe/Ag-EPS NPs was 12 times higher than the production yield of low-Fe/Ag-EPS NPs, confirming the stimulatory effect of iron.
32462243	5	9	theme	NPs	824:826	arg1	higher					841:846	higher	841:846	higher	841:846	The production yield of high-Fe/Ag-EPS NPs was 12 times higher than the production yield of low-Fe/Ag-EPS NPs, confirming the stimulatory effect of iron.
32462243	4	10	theme	scanning	618:625	arg1	analysis					591:598	elemental analysis	581:598	elemental analysis	581:598	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	4	10	theme	scanning	618:625	arg1	microscopy					636:645	transmission and scanning electron microscopy	601:645	microscopy	636:645	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	11	11	theme	Phycoerythrin	2004:2016	arg1	assay					2037:2041	• Phycoerythrin fluorescence-based assay	2002:2041	• Phycoerythrin fluorescence-based assay	2002:2041	• Phycoerythrin fluorescence-based assay was developed to determine Ag+release.
32462243	0	12	theme	phycoerythrin-based	115:133	arg1	assay					135:139	a novel phycoerythrin-based assay	107:139	a novel phycoerythrin-based assay	107:139	Biogenic iron-silver nanoparticles inhibit bacterial biofilm formation due to Ag+ release as determined by a novel phycoerythrin-based assay.
32462243	5	13	theme	production	789:798	arg1	yield					800:804	The production yield	785:804	The production yield of high-Fe/Ag-EPS NPs	785:826	The production yield of high-Fe/Ag-EPS NPs was 12 times higher than the production yield of low-Fe/Ag-EPS NPs, confirming the stimulatory effect of iron.
32462243	5	13	theme	production	789:798	arg1	higher					841:846	higher	841:846	higher	841:846	The production yield of high-Fe/Ag-EPS NPs was 12 times higher than the production yield of low-Fe/Ag-EPS NPs, confirming the stimulatory effect of iron.
32462243	3	14	dep	concentration	549:561	arg1	III					544:546	III	544:546	III	544:546	K. oxytoca DSM 29614 was cultivated in a defined growth medium-containing citrate (as sole carbon source) and supplemented with Ag+ and either low or high Fe(III) concentration.
32462243	7	15	dep	aeruginosa	1371:1380	arg1	ATCC					1382:1385	ATCC 15442	1382:1391	Pseudomonas aeruginosa ATCC 15442	1359:1391	Interestingly, high and low-Fe/Ag-EPS NPs showed different and growth medium-dependent minimal inhibitory concentrations against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 15442.
32462243	8	16	theme	biofilm	1476:1482	arg1	formation					1484:1492	staphylococcal and pseudomonal biofilm formation	1445:1492	staphylococcal and pseudomonal biofilm formation	1445:1492	In addition, low-Fe/Ag-EPS NPs exert inhibition of staphylococcal and pseudomonal biofilm formation, while high-Fe/Ag-EPS NPs inhibits staphylococcal biofilm formation only.
32462243	3	17	theme	Fe	541:542	arg1	concentration					549:561	either low or high Fe(III) concentration	522:561	either low or high Fe(III) concentration	522:561	K. oxytoca DSM 29614 was cultivated in a defined growth medium-containing citrate (as sole carbon source) and supplemented with Ag+ and either low or high Fe(III) concentration.
32462243	6	18	theme	fluorescence-based	1167:1184	arg1	assay					1186:1190	a novel ad hoc established phycoerythrin fluorescence-based assay	1126:1190	a novel ad hoc established phycoerythrin fluorescence-based assay	1126:1190	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	2	19	theme	Fe	257:258	arg1	-citrate					264:271	Fe(III)-citrate	257:271	Fe(III)-citrate	257:271	In the presence of Fe(III)-citrate and Ag+, Klebsiella oxytoca DSM 29614 produces biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS).
32462243	5	20	theme	low-Fe/Ag-EPS	877:889	arg1	NPs					891:893	low-Fe/Ag-EPS NPs	877:893	low-Fe/Ag-EPS NPs	877:893	The production yield of high-Fe/Ag-EPS NPs was 12 times higher than the production yield of low-Fe/Ag-EPS NPs, confirming the stimulatory effect of iron.
32462243	8	21	theme	high-Fe/Ag-EPS	1501:1514	arg1	NPs					1516:1518	high-Fe/Ag-EPS NPs	1501:1518	high-Fe/Ag-EPS NPs	1501:1518	In addition, low-Fe/Ag-EPS NPs exert inhibition of staphylococcal and pseudomonal biofilm formation, while high-Fe/Ag-EPS NPs inhibits staphylococcal biofilm formation only.
32462243	6	22	theme	established	1141:1151	arg1	assay					1186:1190	a novel ad hoc established phycoerythrin fluorescence-based assay	1126:1190	a novel ad hoc established phycoerythrin fluorescence-based assay	1126:1190	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	12	23	theme	Ag+ions	2140:2146	arg1	release					2148:2154	Ag+ions release	2140:2154	Ag+ions release	2140:2154	• Antimicrobial efficacy of bimetal nanoparticle parallels Ag+ions release.
32462243	6	24	theme	Ag	957:958	arg1	content					960:966	relative Ag content	948:966	relative Ag content	948:966	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	9	25	theme	antibacterial	1791:1803	arg1	development					1767:1777	the development	1763:1777	the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag	1763:1921	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	9	26	theme	anti-biofilm	1809:1820	arg1	points					1833:1838	specific antibacterial and anti-biofilm agents.Key points	1782:1838	points	1833:1838	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	8	27	theme	biofilm	1544:1550	arg1	formation					1552:1560	staphylococcal biofilm formation	1529:1560	staphylococcal biofilm formation	1529:1560	In addition, low-Fe/Ag-EPS NPs exert inhibition of staphylococcal and pseudomonal biofilm formation, while high-Fe/Ag-EPS NPs inhibits staphylococcal biofilm formation only.
32462243	1	28	theme	Silver	142:147	arg1	alternative					210:220	a cost-effective alternative	193:220	a cost-effective alternative to antibiotics	193:235	Silver nanoparticles (Ag-NPs) can be considered as a cost-effective alternative to antibiotics.
32462243	1	28	theme	Silver	142:147	arg1	Ag-NPs					164:169	Ag-NPs	164:169	Ag-NPs	164:169	Silver nanoparticles (Ag-NPs) can be considered as a cost-effective alternative to antibiotics.
32462243	1	28	theme	Silver	142:147	arg1	nanoparticles					149:161	Silver nanoparticles	142:161	Silver nanoparticles (Ag-NPs)	142:170	Silver nanoparticles (Ag-NPs) can be considered as a cost-effective alternative to antibiotics.
32462243	9	29	theme	points	1833:1838	arg1	development					1767:1777	the development	1763:1777	the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag	1763:1921	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	5	30	theme	iron	933:936	arg1	effect					923:928	the stimulatory effect	907:928	the stimulatory effect of iron	907:936	The production yield of high-Fe/Ag-EPS NPs was 12 times higher than the production yield of low-Fe/Ag-EPS NPs, confirming the stimulatory effect of iron.
32462243	7	31	theme	ATCC	1344:1347	arg1	29213					1349:1353	Staphylococcus aureus ATCC 29213	1322:1353	Staphylococcus aureus ATCC 29213	1322:1353	Interestingly, high and low-Fe/Ag-EPS NPs showed different and growth medium-dependent minimal inhibitory concentrations against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 15442.
32462243	4	32	theme	light	700:704	arg1	scattering					706:715	dynamic light scattering	692:715	dynamic light scattering	692:715	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	3	33	theme	DSM	397:399	arg1	29614					401:405	K. oxytoca DSM 29614	386:405	K. oxytoca DSM 29614	386:405	K. oxytoca DSM 29614 was cultivated in a defined growth medium-containing citrate (as sole carbon source) and supplemented with Ag+ and either low or high Fe(III) concentration.
32462243	0	34	theme	Biogenic	0:7	arg1	nanoparticles					21:33	Biogenic iron-silver nanoparticles	0:33	Biogenic iron-silver nanoparticles	0:33	Biogenic iron-silver nanoparticles inhibit bacterial biofilm formation due to Ag+ release as determined by a novel phycoerythrin-based assay.
32462243	9	35	theme	different	1612:1620	arg1	capability					1622:1631	the different capability	1608:1631	the different capability of Ag+ release	1608:1646	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	7	36	theme	Staphylococcus	1322:1335	arg1	29213					1349:1353	Staphylococcus aureus ATCC 29213	1322:1353	Staphylococcus aureus ATCC 29213	1322:1353	Interestingly, high and low-Fe/Ag-EPS NPs showed different and growth medium-dependent minimal inhibitory concentrations against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 15442.
32462243	9	37	theme	DSM	1861:1863	arg1	29614					1865:1869	DSM 29614	1861:1869	DSM 29614	1861:1869	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	3	38	theme	defined	427:433	arg1	citrate					460:466	a defined growth medium-containing citrate	425:466	a defined growth medium-containing citrate (as sole carbon source)	425:490	K. oxytoca DSM 29614 was cultivated in a defined growth medium-containing citrate (as sole carbon source) and supplemented with Ag+ and either low or high Fe(III) concentration.
32462243	4	39	dep	transform	656:664	arg1	infrared					666:673	infrared	666:673	transform infrared spectrometry and dynamic light scattering	656:715	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	3	40	theme	K.	386:387	arg1	29614					401:405	K. oxytoca DSM 29614	386:405	K. oxytoca DSM 29614	386:405	K. oxytoca DSM 29614 was cultivated in a defined growth medium-containing citrate (as sole carbon source) and supplemented with Ag+ and either low or high Fe(III) concentration.
32462243	0	41	theme	bacterial	43:51	arg1	formation					61:69	bacterial biofilm formation	43:69	bacterial biofilm formation due to Ag+ release	43:88	Biogenic iron-silver nanoparticles inhibit bacterial biofilm formation due to Ag+ release as determined by a novel phycoerythrin-based assay.
32462243	9	42	theme	bimetal	1880:1886	arg1	nanoparticles					1888:1900	bimetal nanoparticles	1880:1900	bimetal nanoparticles containing Fe and Ag	1880:1921	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	9	43	theme	release	1640:1646	arg1	capability					1622:1631	the different capability	1608:1631	the different capability of Ag+ release	1608:1646	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	2	44	from	exopolysaccharide	361:377	arg1	embedded					336:343	embedded	336:343	embedded	336:343	In the presence of Fe(III)-citrate and Ag+, Klebsiella oxytoca DSM 29614 produces biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS).
32462243	7	45	theme	minimal	1280:1286	arg1	concentrations					1299:1312	different and growth medium-dependent minimal inhibitory concentrations	1242:1312	different and growth medium-dependent minimal inhibitory concentrations	1242:1312	Interestingly, high and low-Fe/Ag-EPS NPs showed different and growth medium-dependent minimal inhibitory concentrations against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 15442.
32462243	2	46	theme	biogenic	320:327	arg1	Ag-NPs					329:334	biogenic Ag-NPs	320:334	biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS)	320:383	In the presence of Fe(III)-citrate and Ag+, Klebsiella oxytoca DSM 29614 produces biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS).
32462243	3	47	theme	medium-containing	442:458	arg1	citrate					460:466	a defined growth medium-containing citrate	425:466	a defined growth medium-containing citrate (as sole carbon source)	425:490	K. oxytoca DSM 29614 was cultivated in a defined growth medium-containing citrate (as sole carbon source) and supplemented with Ag+ and either low or high Fe(III) concentration.
32462243	7	48	theme	different	1242:1250	arg1	concentrations					1299:1312	different and growth medium-dependent minimal inhibitory concentrations	1242:1312	different and growth medium-dependent minimal inhibitory concentrations	1242:1312	Interestingly, high and low-Fe/Ag-EPS NPs showed different and growth medium-dependent minimal inhibitory concentrations against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 15442.
32462243	6	49	theme	ion	976:978	arg1	release					980:986	Ag+ ion release	972:986	Ag+ ion release	972:986	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	8	50	theme	staphylococcal	1445:1458	arg1	formation					1484:1492	staphylococcal and pseudomonal biofilm formation	1445:1492	staphylococcal and pseudomonal biofilm formation	1445:1492	In addition, low-Fe/Ag-EPS NPs exert inhibition of staphylococcal and pseudomonal biofilm formation, while high-Fe/Ag-EPS NPs inhibits staphylococcal biofilm formation only.
32462243	9	51	theme	Fe/Ag-EPS	1671:1679	arg1	NPs					1681:1683	Fe/Ag-EPS NPs	1671:1683	Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614	1671:1716	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	9	51	theme	Fe/Ag-EPS	1671:1679	arg1	candidates					1749:1758	promising candidates	1739:1758	promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag	1739:1921	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	2	52	theme	embedded	336:343	arg1	Ag-NPs					329:334	biogenic Ag-NPs	320:334	biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS)	320:383	In the presence of Fe(III)-citrate and Ag+, Klebsiella oxytoca DSM 29614 produces biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS).
32462243	12	53	theme	bimetal	2109:2115	arg1	nanoparticle					2117:2128	bimetal nanoparticle	2109:2128	bimetal nanoparticle	2109:2128	• Antimicrobial efficacy of bimetal nanoparticle parallels Ag+ions release.
32462243	10	54	theme	growth	1945:1950	arg1	medium					1952:1957	growth medium	1945:1957	growth medium	1945:1957	• Fe concentration in growth medium affects nanoparticle yield and composition.
32462243	2	55	theme	oxytoca	293:299	arg1	29614					305:309	Klebsiella oxytoca DSM 29614	282:309	Klebsiella oxytoca DSM 29614	282:309	In the presence of Fe(III)-citrate and Ag+, Klebsiella oxytoca DSM 29614 produces biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS).
32462243	9	56	theme	K.	1697:1698	arg1	29614					1712:1716	K. oxytoca DSM 29614	1697:1716	K. oxytoca DSM 29614	1697:1716	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	6	57	theme	novel	1128:1132	arg1	assay					1186:1190	a novel ad hoc established phycoerythrin fluorescence-based assay	1126:1190	a novel ad hoc established phycoerythrin fluorescence-based assay	1126:1190	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	5	58	theme	high-Fe/Ag-EPS	809:822	arg1	NPs					824:826	high-Fe/Ag-EPS NPs	809:826	high-Fe/Ag-EPS NPs	809:826	The production yield of high-Fe/Ag-EPS NPs was 12 times higher than the production yield of low-Fe/Ag-EPS NPs, confirming the stimulatory effect of iron.
32462243	10	59	from	concentration	1928:1940	arg1	medium					1952:1957	growth medium	1945:1957	growth medium	1945:1957	• Fe concentration in growth medium affects nanoparticle yield and composition.
32462243	9	60	theme	DSM	1708:1710	arg1	29614					1712:1716	K. oxytoca DSM 29614	1697:1716	K. oxytoca DSM 29614	1697:1716	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	2	61	from	embedded	336:343	arg1	EPS					380:382	EPS	380:382	EPS	380:382	In the presence of Fe(III)-citrate and Ag+, Klebsiella oxytoca DSM 29614 produces biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS).
32462243	2	61	from	embedded	336:343	arg1	exopolysaccharide					361:377	its peculiar exopolysaccharide	348:377	its peculiar exopolysaccharide (EPS)	348:383	In the presence of Fe(III)-citrate and Ag+, Klebsiella oxytoca DSM 29614 produces biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS).
32462243	3	62	theme	low	529:531	arg1	concentration					549:561	either low or high Fe(III) concentration	522:561	either low or high Fe(III) concentration	522:561	K. oxytoca DSM 29614 was cultivated in a defined growth medium-containing citrate (as sole carbon source) and supplemented with Ag+ and either low or high Fe(III) concentration.
32462243	6	63	theme	luminescent	1095:1105	arg1	spectrometry					1107:1118	luminescent spectrometry	1095:1118	luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay	1095:1190	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	5	64	theme	stimulatory	911:921	arg1	effect					923:928	the stimulatory effect	907:928	the stimulatory effect of iron	907:936	The production yield of high-Fe/Ag-EPS NPs was 12 times higher than the production yield of low-Fe/Ag-EPS NPs, confirming the stimulatory effect of iron.
32462243	8	65	theme	pseudomonal	1464:1474	arg1	formation					1484:1492	staphylococcal and pseudomonal biofilm formation	1445:1492	staphylococcal and pseudomonal biofilm formation	1445:1492	In addition, low-Fe/Ag-EPS NPs exert inhibition of staphylococcal and pseudomonal biofilm formation, while high-Fe/Ag-EPS NPs inhibits staphylococcal biofilm formation only.
32462243	11	66	theme	fluorescence-based	2018:2035	arg1	assay					2037:2041	• Phycoerythrin fluorescence-based assay	2002:2041	• Phycoerythrin fluorescence-based assay	2002:2041	• Phycoerythrin fluorescence-based assay was developed to determine Ag+release.
32462243	9	67	theme	promising	1739:1747	arg1	NPs					1681:1683	Fe/Ag-EPS NPs	1671:1683	Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614	1671:1716	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	9	67	theme	promising	1739:1747	arg1	candidates					1749:1758	promising candidates	1739:1758	promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag	1739:1921	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	8	68	theme	formation	1484:1492	arg1	inhibition					1431:1440	inhibition	1431:1440	inhibition of staphylococcal and pseudomonal biofilm formation	1431:1492	In addition, low-Fe/Ag-EPS NPs exert inhibition of staphylococcal and pseudomonal biofilm formation, while high-Fe/Ag-EPS NPs inhibits staphylococcal biofilm formation only.
32462243	4	69	theme	elemental	581:589	arg1	analysis					591:598	elemental analysis	581:598	elemental analysis	581:598	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	4	69	theme	elemental	581:589	arg1	Fourier					648:654	Fourier	648:654	Fourier transform infrared spectrometry and dynamic light scattering	648:715	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	4	69	theme	elemental	581:589	arg1	microscopy					636:645	transmission and scanning electron microscopy	601:645	microscopy	636:645	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	3	70	theme	high	536:539	arg1	concentration					549:561	either low or high Fe(III) concentration	522:561	either low or high Fe(III) concentration	522:561	K. oxytoca DSM 29614 was cultivated in a defined growth medium-containing citrate (as sole carbon source) and supplemented with Ag+ and either low or high Fe(III) concentration.
32462243	5	71	theme	production	857:866	arg1	yield					868:872	the production yield	853:872	the production yield of low-Fe/Ag-EPS NPs	853:893	The production yield of high-Fe/Ag-EPS NPs was 12 times higher than the production yield of low-Fe/Ag-EPS NPs, confirming the stimulatory effect of iron.
32462243	9	72	contain	containing	1902:1911	arg2	Fe					1913:1914	Fe	1913:1914	Fe	1913:1914	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	9	72	contain	containing	1902:1911	arg1	nanoparticles					1888:1900	bimetal nanoparticles	1880:1900	bimetal nanoparticles containing Fe and Ag	1880:1921	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	9	72	contain	containing	1902:1911	arg2	Ag					1920:1921	Ag	1920:1921	Ag	1920:1921	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	6	73	theme	Ag+	972:974	arg1	release					980:986	Ag+ ion release	972:986	Ag+ ion release	972:986	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	6	74	theme	phycoerythrin	1153:1165	arg1	assay					1186:1190	a novel ad hoc established phycoerythrin fluorescence-based assay	1126:1190	a novel ad hoc established phycoerythrin fluorescence-based assay	1126:1190	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	0	75	theme	Ag+	78:80	arg1	release					82:88	Ag+ release	78:88	Ag+ release	78:88	Biogenic iron-silver nanoparticles inhibit bacterial biofilm formation due to Ag+ release as determined by a novel phycoerythrin-based assay.
32462243	9	76	from	candidates	1749:1758	arg1	development					1767:1777	the development	1763:1777	the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag	1763:1921	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	9	77	theme	specific	1782:1789	arg1	antibacterial					1791:1803	specific antibacterial and anti-biofilm agents.Key points	1782:1838	antibacterial	1791:1803	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	8	78	theme	staphylococcal	1529:1542	arg1	formation					1552:1560	staphylococcal biofilm formation	1529:1560	staphylococcal biofilm formation	1529:1560	In addition, low-Fe/Ag-EPS NPs exert inhibition of staphylococcal and pseudomonal biofilm formation, while high-Fe/Ag-EPS NPs inhibits staphylococcal biofilm formation only.
32462243	6	79	theme	hoc	1137:1139	arg1	assay					1186:1190	a novel ad hoc established phycoerythrin fluorescence-based assay	1126:1190	a novel ad hoc established phycoerythrin fluorescence-based assay	1126:1190	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	4	80	theme	electron	627:634	arg1	analysis					591:598	elemental analysis	581:598	elemental analysis	581:598	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	4	80	theme	electron	627:634	arg1	microscopy					636:645	transmission and scanning electron microscopy	601:645	microscopy	636:645	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	6	81	theme	relative	948:955	arg1	content					960:966	relative Ag content	948:966	relative Ag content	948:966	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	2	82	dep	-citrate	264:271	arg1	III					260:262	III	260:262	III	260:262	In the presence of Fe(III)-citrate and Ag+, Klebsiella oxytoca DSM 29614 produces biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS).
32462243	2	82	dep	-citrate	264:271	arg1	the					241:243	the	241:243	the	241:243	In the presence of Fe(III)-citrate and Ag+, Klebsiella oxytoca DSM 29614 produces biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS).
32462243	2	82	dep	-citrate	264:271	arg1	presence					245:252	presence	245:252	presence	245:252	In the presence of Fe(III)-citrate and Ag+, Klebsiella oxytoca DSM 29614 produces biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS).
32462243	4	83	dep	Fourier	648:654	arg1	transform					656:664	transform	656:664	transform infrared spectrometry and dynamic light scattering	656:715	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	9	84	theme	agents.Key	1822:1831	arg1	points					1833:1838	specific antibacterial and anti-biofilm agents.Key points	1782:1838	points	1833:1838	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	4	85	theme	Ag-EPS	718:723	arg1	NPs					725:727	Ag-EPS NPs	718:727	Ag-EPS NPs	718:727	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	0	86	theme	novel	109:113	arg1	assay					135:139	a novel phycoerythrin-based assay	107:139	a novel phycoerythrin-based assay	107:139	Biogenic iron-silver nanoparticles inhibit bacterial biofilm formation due to Ag+ release as determined by a novel phycoerythrin-based assay.
32462243	1	87	theme	cost-effective	195:208	arg1	alternative					210:220	a cost-effective alternative	193:220	a cost-effective alternative to antibiotics	193:235	Silver nanoparticles (Ag-NPs) can be considered as a cost-effective alternative to antibiotics.
32462243	1	87	theme	cost-effective	195:208	arg1	nanoparticles					149:161	Silver nanoparticles	142:161	Silver nanoparticles (Ag-NPs)	142:170	Silver nanoparticles (Ag-NPs) can be considered as a cost-effective alternative to antibiotics.
32462243	7	88	theme	aureus	1337:1342	arg1	29213					1349:1353	Staphylococcus aureus ATCC 29213	1322:1353	Staphylococcus aureus ATCC 29213	1322:1353	Interestingly, high and low-Fe/Ag-EPS NPs showed different and growth medium-dependent minimal inhibitory concentrations against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 15442.
32462243	0	89	theme	iron-silver	9:19	arg1	nanoparticles					21:33	Biogenic iron-silver nanoparticles	0:33	Biogenic iron-silver nanoparticles	0:33	Biogenic iron-silver nanoparticles inhibit bacterial biofilm formation due to Ag+ release as determined by a novel phycoerythrin-based assay.
32462243	5	90	theme	NPs	891:893	arg1	yield					868:872	the production yield	853:872	the production yield of low-Fe/Ag-EPS NPs	853:893	The production yield of high-Fe/Ag-EPS NPs was 12 times higher than the production yield of low-Fe/Ag-EPS NPs, confirming the stimulatory effect of iron.
32462243	6	91	theme	low-Fe/Ag-EPS	1003:1015	arg1	NPs					1017:1019	low-Fe/Ag-EPS NPs	1003:1019	low-Fe/Ag-EPS NPs	1003:1019	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	10	92	theme	•	1923:1923	arg1	concentration					1928:1940	• Fe concentration	1923:1940	• Fe concentration in growth medium	1923:1957	• Fe concentration in growth medium affects nanoparticle yield and composition.
32462243	4	93	theme	dynamic	692:698	arg1	scattering					706:715	dynamic light scattering	692:715	dynamic light scattering	692:715	As inferred from elemental analysis, transmission and scanning electron microscopy, Fourier transform infrared spectrometry and dynamic light scattering, Ag-EPS NPs were produced in both conditions and contained also Fe.
32462243	2	94	theme	peculiar	352:359	arg1	EPS					380:382	EPS	380:382	EPS	380:382	In the presence of Fe(III)-citrate and Ag+, Klebsiella oxytoca DSM 29614 produces biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS).
32462243	2	94	theme	peculiar	352:359	arg1	exopolysaccharide					361:377	its peculiar exopolysaccharide	348:377	its peculiar exopolysaccharide (EPS)	348:383	In the presence of Fe(III)-citrate and Ag+, Klebsiella oxytoca DSM 29614 produces biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS).
32462243	7	95	theme	inhibitory	1288:1297	arg1	concentrations					1299:1312	different and growth medium-dependent minimal inhibitory concentrations	1242:1312	different and growth medium-dependent minimal inhibitory concentrations	1242:1312	Interestingly, high and low-Fe/Ag-EPS NPs showed different and growth medium-dependent minimal inhibitory concentrations against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 15442.
32462243	3	96	theme	growth	435:440	arg1	citrate					460:466	a defined growth medium-containing citrate	425:466	a defined growth medium-containing citrate (as sole carbon source)	425:490	K. oxytoca DSM 29614 was cultivated in a defined growth medium-containing citrate (as sole carbon source) and supplemented with Ag+ and either low or high Fe(III) concentration.
32462243	0	97	theme	biofilm	53:59	arg1	formation					61:69	bacterial biofilm formation	43:69	bacterial biofilm formation due to Ag+ release	43:88	Biogenic iron-silver nanoparticles inhibit bacterial biofilm formation due to Ag+ release as determined by a novel phycoerythrin-based assay.
32462243	9	98	theme	Ag+	1636:1638	arg1	release					1640:1646	Ag+ release	1636:1646	Ag+ release	1636:1646	Altogether, these results, highlighting the different capability of Ag+ release, support the idea that Fe/Ag-EPS NPs produced by K. oxytoca DSM 29614 can be considered as promising candidates in the development of specific antibacterial and anti-biofilm agents.Key points • Klebsiella oxytoca DSM 29614 produces bimetal nanoparticles containing Fe and Ag.
32462243	7	99	theme	medium-dependent	1263:1278	arg1	concentrations					1299:1312	different and growth medium-dependent minimal inhibitory concentrations	1242:1312	different and growth medium-dependent minimal inhibitory concentrations	1242:1312	Interestingly, high and low-Fe/Ag-EPS NPs showed different and growth medium-dependent minimal inhibitory concentrations against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 15442.
32462243	3	100	theme	oxytoca	389:395	arg1	29614					401:405	K. oxytoca DSM 29614	386:405	K. oxytoca DSM 29614	386:405	K. oxytoca DSM 29614 was cultivated in a defined growth medium-containing citrate (as sole carbon source) and supplemented with Ag+ and either low or high Fe(III) concentration.
32462243	6	101	theme	emission-excitation	1064:1082	arg1	spectra					1084:1090	emission-excitation spectra	1064:1090	emission-excitation spectra	1064:1090	However, relative Ag content and Ag+ ion release were higher in low-Fe/Ag-EPS NPs than in high-Fe/Ag-EPS NPs, as revealed by emission-excitation spectra by luminescent spectrometry using a novel ad hoc established phycoerythrin fluorescence-based assay.
32462243	8	102	theme	low-Fe/Ag-EPS	1407:1419	arg1	NPs					1421:1423	low-Fe/Ag-EPS NPs	1407:1423	low-Fe/Ag-EPS NPs	1407:1423	In addition, low-Fe/Ag-EPS NPs exert inhibition of staphylococcal and pseudomonal biofilm formation, while high-Fe/Ag-EPS NPs inhibits staphylococcal biofilm formation only.
32462243	10	103	theme	Fe	1925:1926	arg1	concentration					1928:1940	• Fe concentration	1923:1940	• Fe concentration in growth medium	1923:1957	• Fe concentration in growth medium affects nanoparticle yield and composition.
32462243	2	104	theme	DSM	301:303	arg1	29614					305:309	Klebsiella oxytoca DSM 29614	282:309	Klebsiella oxytoca DSM 29614	282:309	In the presence of Fe(III)-citrate and Ag+, Klebsiella oxytoca DSM 29614 produces biogenic Ag-NPs embedded in its peculiar exopolysaccharide (EPS).
32462243	7	105	theme	low-Fe/Ag-EPS	1217:1229	arg1	NPs					1231:1233	high and low-Fe/Ag-EPS NPs	1208:1233	high and low-Fe/Ag-EPS NPs	1208:1233	Interestingly, high and low-Fe/Ag-EPS NPs showed different and growth medium-dependent minimal inhibitory concentrations against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 15442.
32462243	12	106	theme	•	2081:2081	arg1	efficacy					2097:2104	• Antimicrobial efficacy	2081:2104	• Antimicrobial efficacy of bimetal nanoparticle	2081:2128	• Antimicrobial efficacy of bimetal nanoparticle parallels Ag+ions release.
32462243	10	107	theme	nanoparticle	1967:1978	arg1	yield					1980:1984	nanoparticle yield	1967:1984	nanoparticle yield	1967:1984	• Fe concentration in growth medium affects nanoparticle yield and composition.
32462243	7	108	theme	high	1208:1211	arg1	NPs					1231:1233	high and low-Fe/Ag-EPS NPs	1208:1233	high and low-Fe/Ag-EPS NPs	1208:1233	Interestingly, high and low-Fe/Ag-EPS NPs showed different and growth medium-dependent minimal inhibitory concentrations against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 15442.
34072476	1	0	theme	combination	135:145	arg1	presence					121:128	the presence	117:128	the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow	117:350	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	3	1	theme	endothelial	586:596	arg1	cells					598:602	endothelial cells	586:602	endothelial cells	586:602	In order to investigate the effect of inflammation on the onset of vascular disease, we treated endothelial cells with the cytokine TNF-α that is increased in obese patients and is reported to induce cardiometabolic diseases.
34072476	4	2	theme	extracellular	763:775	arg1	matrix					777:782	the extracellular matrix	759:782	the extracellular matrix	759:782	The inflammation induced a large change in the extracellular matrix, increasing the pericellular hyaluronan and altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation.
34072476	1	3	theme	physical	213:220	arg1	obesity					204:210	obesity	204:210	obesity	204:210	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	1	3	theme	physical	213:220	arg1	inactivity					222:231	physical inactivity	213:231	physical inactivity	213:231	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	4	4	theme	Syndecans	857:865	arg1	sets					867:870	the heparan sulfate Syndecans sets	837:870	the heparan sulfate Syndecans sets	837:870	The inflammation induced a large change in the extracellular matrix, increasing the pericellular hyaluronan and altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation.
34072476	1	5	theme	inflammation	369:380	arg1	condition					382:390	an inflammation condition	366:390	an inflammation condition	366:390	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	1	6	theme	Cardiovascular	58:71	arg1	diseases					73:80	Cardiovascular diseases	58:80	Cardiovascular diseases	58:80	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	1	6	theme	Cardiovascular	58:71	arg1	group					88:92	a group	86:92	a group	86:92	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	1	6	theme	Cardiovascular	58:71	arg1	disorders					97:105	disorders	97:105	disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow	97:350	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	3	7	from	effect	518:523	arg1	onset					548:552	the onset	544:552	the onset of vascular disease	544:572	In order to investigate the effect of inflammation on the onset of vascular disease, we treated endothelial cells with the cytokine TNF-α that is increased in obese patients and is reported to induce cardiometabolic diseases.
34072476	1	8	theme	matrix	304:309	arg1	composition					276:286	the composition	272:286	the composition of the vessel's matrix	272:309	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	4	9	dep	cell	944:947	arg1	proliferation					949:961	proliferation	949:961	proliferation	949:961	The inflammation induced a large change in the extracellular matrix, increasing the pericellular hyaluronan and altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation.
34072476	4	10	dep	induced	733:739	arg1	altering					828:835	altering	828:835	altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation	828:1022	The inflammation induced a large change in the extracellular matrix, increasing the pericellular hyaluronan and altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation.
34072476	4	10	dep	induced	733:739	arg1	increasing					785:794	increasing	785:794	increasing the pericellular hyaluronan	785:822	The inflammation induced a large change in the extracellular matrix, increasing the pericellular hyaluronan and altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation.
34072476	1	11	theme	risk	150:153	arg1	obesity					204:210	obesity	204:210	obesity	204:210	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	1	11	theme	risk	150:153	arg1	use					180:182	tobacco use	172:182	tobacco use	172:182	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	1	11	theme	risk	150:153	arg1	factors					155:161	risk factors	150:161	risk factors	150:161	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	1	11	theme	risk	150:153	arg1	diet					195:198	unhealthy diet	185:198	unhealthy diet	185:198	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	3	12	theme	cytokine	613:620	arg1	TNF-α					622:626	the cytokine TNF-α	609:626	the cytokine TNF-α that is increased in obese patients and is reported to induce cardiometabolic diseases	609:713	In order to investigate the effect of inflammation on the onset of vascular disease, we treated endothelial cells with the cytokine TNF-α that is increased in obese patients and is reported to induce cardiometabolic diseases.
34072476	4	13	theme	layer	902:906	arg1	permeability					908:919	layer permeability	902:919	layer permeability	902:919	The inflammation induced a large change in the extracellular matrix, increasing the pericellular hyaluronan and altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation.
34072476	1	14	theme	factors	155:161	arg1	combination					135:145	a combination	133:145	a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow	133:350	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	4	15	dep	cell	993:996	arg1	recruitment					998:1008	recruitment	998:1008	recruitment	998:1008	The inflammation induced a large change in the extracellular matrix, increasing the pericellular hyaluronan and altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation.
34072476	3	16	theme	obese	649:653	arg1	patients					655:662	obese patients	649:662	obese patients	649:662	In order to investigate the effect of inflammation on the onset of vascular disease, we treated endothelial cells with the cytokine TNF-α that is increased in obese patients and is reported to induce cardiometabolic diseases.
34072476	4	17	theme	heparan	841:847	arg1	sulfate					849:855	heparan sulfate	841:855	the heparan sulfate Syndecans sets	837:870	The inflammation induced a large change in the extracellular matrix, increasing the pericellular hyaluronan and altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation.
34072476	1	18	theme	disorders	97:105	arg1	diseases					73:80	Cardiovascular diseases	58:80	Cardiovascular diseases	58:80	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	1	18	theme	disorders	97:105	arg1	group					88:92	a group	86:92	a group	86:92	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	1	18	theme	disorders	97:105	arg1	disorders					97:105	disorders	97:105	disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow	97:350	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	1	19	theme	tobacco	172:178	arg1	use					180:182	tobacco use	172:182	tobacco use	172:182	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	0	20	theme	Endothelial	21:31	arg1	Activation					46:55	Endothelial Inflammatory Activation	21:55	Endothelial Inflammatory Activation	21:55	HA and HS Changes in Endothelial Inflammatory Activation.
34072476	4	21	theme	sulfate	849:855	arg1	sets					867:870	the heparan sulfate Syndecans sets	837:870	the heparan sulfate Syndecans sets	837:870	The inflammation induced a large change in the extracellular matrix, increasing the pericellular hyaluronan and altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation.
34072476	3	22	theme	vascular	557:564	arg1	disease					566:572	vascular disease	557:572	vascular disease	557:572	In order to investigate the effect of inflammation on the onset of vascular disease, we treated endothelial cells with the cytokine TNF-α that is increased in obese patients and is reported to induce cardiometabolic diseases.
34072476	2	23	theme	permissive	448:457	arg1	inflammation					430:441	the inflammation	426:441	the inflammation	426:441	Nevertheless, it is not clear if the inflammation is a permissive condition or a consequent one.
34072476	2	23	theme	permissive	448:457	arg1	condition					459:467	a permissive condition	446:467	a permissive condition	446:467	Nevertheless, it is not clear if the inflammation is a permissive condition or a consequent one.
34072476	4	24	theme	pericellular	800:811	arg1	hyaluronan					813:822	the pericellular hyaluronan	796:822	the pericellular hyaluronan	796:822	The inflammation induced a large change in the extracellular matrix, increasing the pericellular hyaluronan and altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation.
34072476	4	25	from	change	749:754	arg1	matrix					777:782	the extracellular matrix	759:782	the extracellular matrix	759:782	The inflammation induced a large change in the extracellular matrix, increasing the pericellular hyaluronan and altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation.
34072476	0	26	theme	Inflammatory	33:44	arg1	Activation					46:55	Endothelial Inflammatory Activation	21:55	Endothelial Inflammatory Activation	21:55	HA and HS Changes in Endothelial Inflammatory Activation.
34072476	1	27	theme	blood	341:345	arg1	flow					347:350	blood flow	341:350	blood flow	341:350	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	4	28	theme	large	743:747	arg1	change					749:754	a large change	741:754	a large change in the extracellular matrix	741:782	The inflammation induced a large change in the extracellular matrix, increasing the pericellular hyaluronan and altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation.
34072476	4	29	theme	blood	987:991	arg1	cell					993:996	blood cell recruitment or activation	987:1022	cell	993:996	The inflammation induced a large change in the extracellular matrix, increasing the pericellular hyaluronan and altering the heparan sulfate Syndecans sets, which seems to be related to layer permeability but does not influence cell proliferation or migration nor induce blood cell recruitment or activation.
34072476	1	30	theme	flow	347:350	arg1	alteration					327:336	the alteration	323:336	the alteration of blood flow	323:350	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	3	31	theme	inflammation	528:539	arg1	effect					518:523	the effect	514:523	the effect of inflammation on the onset of vascular disease	514:572	In order to investigate the effect of inflammation on the onset of vascular disease, we treated endothelial cells with the cytokine TNF-α that is increased in obese patients and is reported to induce cardiometabolic diseases.
34072476	1	32	theme	unhealthy	185:193	arg1	diet					195:198	unhealthy diet	185:198	unhealthy diet	185:198	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	2	33	theme	consequent	474:483	arg1	one					485:487	a consequent one	472:487	a consequent one	472:487	Nevertheless, it is not clear if the inflammation is a permissive condition or a consequent one.
34072476	3	34	theme	disease	566:572	arg1	onset					548:552	the onset	544:552	the onset of vascular disease	544:572	In order to investigate the effect of inflammation on the onset of vascular disease, we treated endothelial cells with the cytokine TNF-α that is increased in obese patients and is reported to induce cardiometabolic diseases.
34072476	1	35	theme	composition	276:286	arg1	modification					256:267	the modification	252:267	the modification of the composition of the vessel's matrix	252:309	Cardiovascular diseases are a group of disorders caused by the presence of a combination of risk factors, such as tobacco use, unhealthy diet and obesity, physical inactivity, etc., which cause the modification of the composition of the vessel's matrix and lead to the alteration of blood flow, matched with an inflammation condition.
34072476	3	36	theme	cardiometabolic	690:704	arg1	diseases					706:713	cardiometabolic diseases	690:713	cardiometabolic diseases	690:713	In order to investigate the effect of inflammation on the onset of vascular disease, we treated endothelial cells with the cytokine TNF-α that is increased in obese patients and is reported to induce cardiometabolic diseases.
35236214	9	0	from	NP1s-Rb	1347:1353	arg1	release					1334:1340	the RIF release	1326:1340	the RIF release from NP1s-Rb and NP4s-Rb, respectively	1326:1379	The Weibull and the Korsmeyer-Peppas models better describe the RIF release from NP1s-Rb and NP4s-Rb, respectively, demonstrating that the release process was driven by different mechanism according to the particle composition.
35236214	7	1	theme	promising	1003:1011	arg1	characteristics					1013:1027	the most promising characteristics	994:1027	the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%)	994:1113	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	2	2	from	influence	412:420	arg1	characteristics					439:453	the nano PECs characteristics	425:453	the nano PECs characteristics	425:453	Different polymer proportions were tested, as well as the addition order and homogenization type, to assess the influence on the nano PECs characteristics.
35236214	1	3	theme	nano	188:191	arg1	complexes					177:185	Nanostructured polyelectrolyte complexes	146:185	Nanostructured polyelectrolyte complexes (nano PECs)	146:197	Nanostructured polyelectrolyte complexes (nano PECs) were obtained by polyelectrolyte complexation technique from chitosan (CS) and sodium alginate (SA).
35236214	1	3	theme	nano	188:191	arg1	PECs					193:196	nano PECs	188:196	nano PECs	188:196	Nanostructured polyelectrolyte complexes (nano PECs) were obtained by polyelectrolyte complexation technique from chitosan (CS) and sodium alginate (SA).
35236214	9	4	from	NP4s-Rb	1359:1365	arg1	release					1334:1340	the RIF release	1326:1340	the RIF release from NP1s-Rb and NP4s-Rb, respectively	1326:1379	The Weibull and the Korsmeyer-Peppas models better describe the RIF release from NP1s-Rb and NP4s-Rb, respectively, demonstrating that the release process was driven by different mechanism according to the particle composition.
35236214	4	5	theme	PECs	570:573	arg1	size					575:578	Nano PECs size	565:578	Nano PECs size	565:578	Nano PECs size, PDI, and zeta potential (ZP) ranged from 252 to 616 nm, from 0.22 to 0.73 and -50 to 30 mV, respectively.
35236214	12	6	theme	RIF	1725:1727	arg1	incorporation					1708:1720	the incorporation	1704:1720	the incorporation of RIF in nano PECs based on CS and SA	1704:1759	Therefore, with the results obtained, the incorporation of RIF in nano PECs based on CS and SA presents a promising system for the treatment of tuberculosis.
35236214	3	7	theme	systems	504:510	arg1	scale					491:495	nanometric scale	480:495	nanometric scale	480:495	The spherical shape and nanometric scale of the systems were observed by scanning electron microscopy (SEM).
35236214	3	7	theme	systems	504:510	arg1	shape					470:474	spherical shape	460:474	spherical shape	460:474	The spherical shape and nanometric scale of the systems were observed by scanning electron microscopy (SEM).
35236214	1	8	theme	sodium	278:283	arg1	SA					295:296	SA	295:296	SA	295:296	Nanostructured polyelectrolyte complexes (nano PECs) were obtained by polyelectrolyte complexation technique from chitosan (CS) and sodium alginate (SA).
35236214	1	8	theme	sodium	278:283	arg1	alginate					285:292	sodium alginate	278:292	sodium alginate (SA)	278:297	Nanostructured polyelectrolyte complexes (nano PECs) were obtained by polyelectrolyte complexation technique from chitosan (CS) and sodium alginate (SA).
35236214	0	9	theme	potential	109:117	arg1	treatment					119:127	the potential treatment	105:127	the potential treatment of tuberculosis	105:143	Nanostructured polyelectrolyte complexes based on chitosan and sodium alginate containing rifampicin for the potential treatment of tuberculosis.
35236214	5	10	dep	particles	784:792	arg1	particles					784:792	particles size and PDI	784:805	particles size and PDI	784:805	The increase of polymer proportion and the ultra-turrax homogenization led to the enlargement of particles size and PDI.
35236214	5	10	dep	particles	784:792	arg1	PDI					803:805	PDI	803:805	PDI	803:805	The increase of polymer proportion and the ultra-turrax homogenization led to the enlargement of particles size and PDI.
35236214	5	10	dep	particles	784:792	arg1	size					794:797	size	794:797	size	794:797	The increase of polymer proportion and the ultra-turrax homogenization led to the enlargement of particles size and PDI.
35236214	2	11	theme	Different	300:308	arg1	proportions					318:328	Different polymer proportions	300:328	Different polymer proportions	300:328	Different polymer proportions were tested, as well as the addition order and homogenization type, to assess the influence on the nano PECs characteristics.
35236214	0	12	contain	containing	79:88	arg1	chitosan					50:57	chitosan	50:57	chitosan	50:57	Nanostructured polyelectrolyte complexes based on chitosan and sodium alginate containing rifampicin for the potential treatment of tuberculosis.
35236214	0	12	contain	containing	79:88	arg2	rifampicin					90:99	rifampicin	90:99	rifampicin	90:99	Nanostructured polyelectrolyte complexes based on chitosan and sodium alginate containing rifampicin for the potential treatment of tuberculosis.
35236214	7	13	dep	NP1s-Rb	858:864	arg1	The					854:856	The	854:856	The	854:856	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	10	14	theme	possible	1557:1564	arg1	nebulization					1566:1577	possible nebulization	1557:1577	possible nebulization	1557:1577	The nano PECs were lyophilized to prolong it stability and for possible nebulization.
35236214	7	15	theme	incorporation	1088:1100	arg1	characteristics					1013:1027	the most promising characteristics	994:1027	the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%)	994:1113	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	0	16	theme	Nanostructured	0:13	arg1	complexes					31:39	Nanostructured polyelectrolyte complexes	0:39	Nanostructured polyelectrolyte complexes	0:39	Nanostructured polyelectrolyte complexes based on chitosan and sodium alginate containing rifampicin for the potential treatment of tuberculosis.
35236214	3	17	theme	nanometric	480:489	arg1	scale					491:495	nanometric scale	480:495	nanometric scale	480:495	The spherical shape and nanometric scale of the systems were observed by scanning electron microscopy (SEM).
35236214	7	18	theme	PDI	1059:1061	arg1	characteristics					1013:1027	the most promising characteristics	994:1027	the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%)	994:1113	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	12	19	theme	nano	1732:1735	arg1	PECs					1737:1740	nano PECs	1732:1740	nano PECs	1732:1740	Therefore, with the results obtained, the incorporation of RIF in nano PECs based on CS and SA presents a promising system for the treatment of tuberculosis.
35236214	9	20	theme	particle	1472:1479	arg1	composition					1481:1491	the particle composition	1468:1491	the particle composition	1468:1491	The Weibull and the Korsmeyer-Peppas models better describe the RIF release from NP1s-Rb and NP4s-Rb, respectively, demonstrating that the release process was driven by different mechanism according to the particle composition.
35236214	12	21	from	incorporation	1708:1720	arg1	PECs					1737:1740	nano PECs	1732:1740	nano PECs	1732:1740	Therefore, with the results obtained, the incorporation of RIF in nano PECs based on CS and SA presents a promising system for the treatment of tuberculosis.
35236214	5	22	theme	proportion	711:720	arg1	homogenization					743:756	the ultra-turrax homogenization	726:756	the ultra-turrax homogenization	726:756	The increase of polymer proportion and the ultra-turrax homogenization led to the enlargement of particles size and PDI.
35236214	5	22	theme	proportion	711:720	arg1	increase					691:698	The increase	687:698	The increase of polymer proportion	687:720	The increase of polymer proportion and the ultra-turrax homogenization led to the enlargement of particles size and PDI.
35236214	7	23	dep	CS	949:950	arg1	complexation					959:970	complexation	959:970	complexation	959:970	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	3	24	theme	scanning	529:536	arg1	SEM					559:561	SEM	559:561	SEM	559:561	The spherical shape and nanometric scale of the systems were observed by scanning electron microscopy (SEM).
35236214	3	24	theme	scanning	529:536	arg1	microscopy					547:556	scanning electron microscopy	529:556	scanning electron microscopy (SEM)	529:562	The spherical shape and nanometric scale of the systems were observed by scanning electron microscopy (SEM).
35236214	0	25	theme	polyelectrolyte	15:29	arg1	complexes					31:39	Nanostructured polyelectrolyte complexes	0:39	Nanostructured polyelectrolyte complexes	0:39	Nanostructured polyelectrolyte complexes based on chitosan and sodium alginate containing rifampicin for the potential treatment of tuberculosis.
35236214	8	26	theme	drug	1221:1224	arg1	release					1206:1212	a sustained release	1194:1212	a sustained release of the drug for 180 min in phosphate buffer pH 7.2	1194:1263	The release profiles of RIF incorporated in both nano PECs were similar, with a sustained release of the drug for 180 min in phosphate buffer pH 7.2.
35236214	7	27	theme	69	1110:1111	arg1	%					1112:1112	78 and 69%	1103:1112	%	1112:1112	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	7	27	theme	69	1110:1111	arg1	incorporation					1088:1100	RIF incorporation	1084:1100	RIF incorporation (78 and 69%)	1084:1113	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	2	28	theme	PECs	434:437	arg1	characteristics					439:453	the nano PECs characteristics	425:453	the nano PECs characteristics	425:453	Different polymer proportions were tested, as well as the addition order and homogenization type, to assess the influence on the nano PECs characteristics.
35236214	10	29	theme	nano	1498:1501	arg1	PECs					1503:1506	The nano PECs	1494:1506	The nano PECs	1494:1506	The nano PECs were lyophilized to prolong it stability and for possible nebulization.
35236214	2	30	theme	homogenization	377:390	arg1	type					392:395	homogenization type	377:395	homogenization type	377:395	Different polymer proportions were tested, as well as the addition order and homogenization type, to assess the influence on the nano PECs characteristics.
35236214	2	31	theme	nano	429:432	arg1	characteristics					439:453	the nano PECs characteristics	425:453	the nano PECs characteristics	425:453	Different polymer proportions were tested, as well as the addition order and homogenization type, to assess the influence on the nano PECs characteristics.
35236214	8	32	theme	release	1120:1126	arg1	profiles					1128:1135	The release profiles	1116:1135	The release profiles of RIF incorporated in both nano PECs	1116:1173	The release profiles of RIF incorporated in both nano PECs were similar, with a sustained release of the drug for 180 min in phosphate buffer pH 7.2.
35236214	8	32	theme	release	1120:1126	arg1	similar					1180:1186	similar	1180:1186	similar	1180:1186	The release profiles of RIF incorporated in both nano PECs were similar, with a sustained release of the drug for 180 min in phosphate buffer pH 7.2.
35236214	4	33	dep	0.73	650:653	arg1	to					647:648	to	647:648	to	647:648	Nano PECs size, PDI, and zeta potential (ZP) ranged from 252 to 616 nm, from 0.22 to 0.73 and -50 to 30 mV, respectively.
35236214	8	34	from	180 min	1230:1236	arg1	pH					1258:1259	phosphate buffer pH 7.2	1241:1263	phosphate buffer pH 7.2	1241:1263	The release profiles of RIF incorporated in both nano PECs were similar, with a sustained release of the drug for 180 min in phosphate buffer pH 7.2.
35236214	1	35	theme	polyelectrolyte	216:230	arg1	technique					245:253	polyelectrolyte complexation technique	216:253	polyelectrolyte complexation technique	216:253	Nanostructured polyelectrolyte complexes (nano PECs) were obtained by polyelectrolyte complexation technique from chitosan (CS) and sodium alginate (SA).
35236214	11	36	theme	dextrose	1596:1603	arg1	addition					1584:1591	The addition	1580:1591	The addition of dextrose to the system	1580:1617	The addition of dextrose to the system allowed for resuspension after lyophilization.
35236214	0	37	theme	tuberculosis	132:143	arg1	treatment					119:127	the potential treatment	105:127	the potential treatment of tuberculosis	105:143	Nanostructured polyelectrolyte complexes based on chitosan and sodium alginate containing rifampicin for the potential treatment of tuberculosis.
35236214	8	38	theme	buffer	1251:1256	arg1	pH					1258:1259	phosphate buffer pH 7.2	1241:1263	phosphate buffer pH 7.2	1241:1263	The release profiles of RIF incorporated in both nano PECs were similar, with a sustained release of the drug for 180 min in phosphate buffer pH 7.2.
35236214	2	39	theme	polymer	310:316	arg1	proportions					318:328	Different polymer proportions	300:328	Different polymer proportions	300:328	Different polymer proportions were tested, as well as the addition order and homogenization type, to assess the influence on the nano PECs characteristics.
35236214	1	40	theme	complexation	232:243	arg1	technique					245:253	polyelectrolyte complexation technique	216:253	polyelectrolyte complexation technique	216:253	Nanostructured polyelectrolyte complexes (nano PECs) were obtained by polyelectrolyte complexation technique from chitosan (CS) and sodium alginate (SA).
35236214	5	41	theme	polymer	703:709	arg1	proportion					711:720	polymer proportion	703:720	polymer proportion	703:720	The increase of polymer proportion and the ultra-turrax homogenization led to the enlargement of particles size and PDI.
35236214	12	42	theme	promising	1772:1780	arg1	system					1782:1787	a promising system	1770:1787	a promising system for the treatment of tuberculosis	1770:1821	Therefore, with the results obtained, the incorporation of RIF in nano PECs based on CS and SA presents a promising system for the treatment of tuberculosis.
35236214	8	43	theme	phosphate	1241:1249	arg1	pH					1258:1259	phosphate buffer pH 7.2	1241:1263	phosphate buffer pH 7.2	1241:1263	The release profiles of RIF incorporated in both nano PECs were similar, with a sustained release of the drug for 180 min in phosphate buffer pH 7.2.
35236214	8	44	theme	RIF	1140:1142	arg1	profiles					1128:1135	The release profiles	1116:1135	The release profiles of RIF incorporated in both nano PECs	1116:1173	The release profiles of RIF incorporated in both nano PECs were similar, with a sustained release of the drug for 180 min in phosphate buffer pH 7.2.
35236214	8	44	theme	RIF	1140:1142	arg1	similar					1180:1186	similar	1180:1186	similar	1180:1186	The release profiles of RIF incorporated in both nano PECs were similar, with a sustained release of the drug for 180 min in phosphate buffer pH 7.2.
35236214	12	45	from	RIF	1725:1727	arg1	PECs					1737:1740	nano PECs	1732:1740	nano PECs	1732:1740	Therefore, with the results obtained, the incorporation of RIF in nano PECs based on CS and SA presents a promising system for the treatment of tuberculosis.
35236214	9	46	theme	RIF	1330:1332	arg1	release					1334:1340	the RIF release	1326:1340	the RIF release from NP1s-Rb and NP4s-Rb, respectively	1326:1379	The Weibull and the Korsmeyer-Peppas models better describe the RIF release from NP1s-Rb and NP4s-Rb, respectively, demonstrating that the release process was driven by different mechanism according to the particle composition.
35236214	4	47	dep	616 nm	629:634	arg1	to					626:627	to	626:627	to	626:627	Nano PECs size, PDI, and zeta potential (ZP) ranged from 252 to 616 nm, from 0.22 to 0.73 and -50 to 30 mV, respectively.
35236214	4	48	theme	Nano	565:568	arg1	size					575:578	Nano PECs size	565:578	Nano PECs size	565:578	Nano PECs size, PDI, and zeta potential (ZP) ranged from 252 to 616 nm, from 0.22 to 0.73 and -50 to 30 mV, respectively.
35236214	7	49	with	sonicator	900:908	arg1	RIF					927:929	RIF	927:929	RIF	927:929	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	7	49	with	sonicator	900:908	arg1	rifampicin					915:924	rifampicin	915:924	rifampicin (RIF) added before the CS and SA complexation	915:970	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	5	50	theme	particles	784:792	arg1	enlargement					769:779	the enlargement	765:779	the enlargement of particles size and PDI	765:805	The increase of polymer proportion and the ultra-turrax homogenization led to the enlargement of particles size and PDI.
35236214	0	51	theme	sodium	63:68	arg1	alginate					70:77	sodium alginate	63:77	sodium alginate	63:77	Nanostructured polyelectrolyte complexes based on chitosan and sodium alginate containing rifampicin for the potential treatment of tuberculosis.
35236214	8	52	theme	nano	1165:1168	arg1	PECs					1170:1173	both nano PECs	1160:1173	both nano PECs	1160:1173	The release profiles of RIF incorporated in both nano PECs were similar, with a sustained release of the drug for 180 min in phosphate buffer pH 7.2.
35236214	9	53	theme	release	1405:1411	arg1	process					1413:1419	the release process	1401:1419	the release process	1401:1419	The Weibull and the Korsmeyer-Peppas models better describe the RIF release from NP1s-Rb and NP4s-Rb, respectively, demonstrating that the release process was driven by different mechanism according to the particle composition.
35236214	7	54	theme	diameter	1032:1039	arg1	characteristics					1013:1027	the most promising characteristics	994:1027	the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%)	994:1113	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	7	55	theme	78	1103:1104	arg1	%					1112:1112	78 and 69%	1103:1112	%	1112:1112	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	7	55	theme	78	1103:1104	arg1	incorporation					1088:1100	RIF incorporation	1084:1100	RIF incorporation (78 and 69%)	1084:1113	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	9	56	dep	Weibull	1270:1276	arg1	models					1303:1308	models	1303:1308	models	1303:1308	The Weibull and the Korsmeyer-Peppas models better describe the RIF release from NP1s-Rb and NP4s-Rb, respectively, demonstrating that the release process was driven by different mechanism according to the particle composition.
35236214	8	57	theme	sustained	1196:1204	arg1	release					1206:1212	a sustained release	1194:1212	a sustained release of the drug for 180 min in phosphate buffer pH 7.2	1194:1263	The release profiles of RIF incorporated in both nano PECs were similar, with a sustained release of the drug for 180 min in phosphate buffer pH 7.2.
35236214	1	58	theme	Nanostructured	146:159	arg1	complexes					177:185	Nanostructured polyelectrolyte complexes	146:185	Nanostructured polyelectrolyte complexes (nano PECs)	146:197	Nanostructured polyelectrolyte complexes (nano PECs) were obtained by polyelectrolyte complexation technique from chitosan (CS) and sodium alginate (SA).
35236214	1	58	theme	Nanostructured	146:159	arg1	PECs					193:196	nano PECs	188:196	nano PECs	188:196	Nanostructured polyelectrolyte complexes (nano PECs) were obtained by polyelectrolyte complexation technique from chitosan (CS) and sodium alginate (SA).
35236214	12	59	from	PECs	1737:1740	arg1	incorporation					1708:1720	the incorporation	1704:1720	the incorporation of RIF in nano PECs based on CS and SA	1704:1759	Therefore, with the results obtained, the incorporation of RIF in nano PECs based on CS and SA presents a promising system for the treatment of tuberculosis.
35236214	2	60	dep	order	367:371	arg1	the					354:356	the	354:356	the	354:356	Different polymer proportions were tested, as well as the addition order and homogenization type, to assess the influence on the nano PECs characteristics.
35236214	8	61	with	similar	1180:1186	arg1	release					1206:1212	a sustained release	1194:1212	a sustained release of the drug for 180 min in phosphate buffer pH 7.2	1194:1263	The release profiles of RIF incorporated in both nano PECs were similar, with a sustained release of the drug for 180 min in phosphate buffer pH 7.2.
35236214	3	62	theme	electron	538:545	arg1	SEM					559:561	SEM	559:561	SEM	559:561	The spherical shape and nanometric scale of the systems were observed by scanning electron microscopy (SEM).
35236214	3	62	theme	electron	538:545	arg1	microscopy					547:556	scanning electron microscopy	529:556	scanning electron microscopy (SEM)	529:562	The spherical shape and nanometric scale of the systems were observed by scanning electron microscopy (SEM).
35236214	1	63	theme	polyelectrolyte	161:175	arg1	complexes					177:185	Nanostructured polyelectrolyte complexes	146:185	Nanostructured polyelectrolyte complexes (nano PECs)	146:197	Nanostructured polyelectrolyte complexes (nano PECs) were obtained by polyelectrolyte complexation technique from chitosan (CS) and sodium alginate (SA).
35236214	1	63	theme	polyelectrolyte	161:175	arg1	PECs					193:196	nano PECs	188:196	nano PECs	188:196	Nanostructured polyelectrolyte complexes (nano PECs) were obtained by polyelectrolyte complexation technique from chitosan (CS) and sodium alginate (SA).
35236214	4	64	dep	30 mV	666:670	arg1	to					663:664	to	663:664	to	663:664	Nano PECs size, PDI, and zeta potential (ZP) ranged from 252 to 616 nm, from 0.22 to 0.73 and -50 to 30 mV, respectively.
35236214	12	65	theme	tuberculosis	1810:1821	arg1	treatment					1797:1805	the treatment	1793:1805	the treatment of tuberculosis	1793:1821	Therefore, with the results obtained, the incorporation of RIF in nano PECs based on CS and SA presents a promising system for the treatment of tuberculosis.
35236214	6	66	located	observed	834:841	arg1	ZP					850:851	the ZP	846:851	the ZP	846:851	However, no influence was observed on the ZP.
35236214	6	66	located	observed	834:841	arg2	influence					820:828	no influence	817:828	no influence	817:828	However, no influence was observed on the ZP.
35236214	3	67	theme	spherical	460:468	arg1	shape					470:474	spherical shape	460:474	spherical shape	460:474	The spherical shape and nanometric scale of the systems were observed by scanning electron microscopy (SEM).
35236214	2	68	theme	addition	358:365	arg1	order					367:371	addition order	358:371	addition order	358:371	Different polymer proportions were tested, as well as the addition order and homogenization type, to assess the influence on the nano PECs characteristics.
35236214	4	69	theme	zeta	590:593	arg1	ZP					606:607	ZP	606:607	ZP	606:607	Nano PECs size, PDI, and zeta potential (ZP) ranged from 252 to 616 nm, from 0.22 to 0.73 and -50 to 30 mV, respectively.
35236214	4	69	theme	zeta	590:593	arg1	potential					595:603	zeta potential	590:603	zeta potential (ZP)	590:608	Nano PECs size, PDI, and zeta potential (ZP) ranged from 252 to 616 nm, from 0.22 to 0.73 and -50 to 30 mV, respectively.
35236214	3	70	dep	shape	470:474	arg1	The					456:458	The	456:458	The	456:458	The spherical shape and nanometric scale of the systems were observed by scanning electron microscopy (SEM).
35236214	5	71	theme	ultra-turrax	730:741	arg1	homogenization					743:756	the ultra-turrax homogenization	726:756	the ultra-turrax homogenization	726:756	The increase of polymer proportion and the ultra-turrax homogenization led to the enlargement of particles size and PDI.
35236214	7	72	theme	RIF	1084:1086	arg1	%					1112:1112	78 and 69%	1103:1112	%	1112:1112	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	7	72	theme	RIF	1084:1086	arg1	incorporation					1088:1100	RIF incorporation	1084:1100	RIF incorporation (78 and 69%)	1084:1113	The NP1s-Rb and NP4s-Rb, obtained through the sonicator with rifampicin (RIF) added before the CS and SA complexation, were selected due to the most promising characteristics of diameter (301 and 402 nm), PDI (0.27 and 0.26), and RIF incorporation (78 and 69%).
35236214	9	73	theme	different	1435:1443	arg1	mechanism					1445:1453	different mechanism	1435:1453	different mechanism according to the particle composition	1435:1491	The Weibull and the Korsmeyer-Peppas models better describe the RIF release from NP1s-Rb and NP4s-Rb, respectively, demonstrating that the release process was driven by different mechanism according to the particle composition.
34325341	8	0	theme	minimum	1068:1074	arg1	-49.24 dB					1109:1117	-49.24 dB	1109:1117	-49.24 dB	1109:1117	The minimum reflection loss (RLmin) value is -49.24 dB, and the effective absorption bandwidth (RL < -10 dB, fe) reaches 6.90 GHz.
34325341	8	0	theme	minimum	1068:1074	arg1	value					1100:1104	The minimum reflection loss (RLmin) value	1064:1104	The minimum reflection loss (RLmin) value	1064:1104	The minimum reflection loss (RLmin) value is -49.24 dB, and the effective absorption bandwidth (RL < -10 dB, fe) reaches 6.90 GHz.
34325341	8	1	theme	absorption	1138:1147	arg1	bandwidth					1149:1157	the effective absorption bandwidth	1124:1157	the effective absorption bandwidth (RL < -10 dB, fe)	1124:1175	The minimum reflection loss (RLmin) value is -49.24 dB, and the effective absorption bandwidth (RL < -10 dB, fe) reaches 6.90 GHz.
34325341	1	2	theme	anti-fatigue	269:280	arg1	characteristics					282:296	anti-fatigue characteristics	269:296	anti-fatigue characteristics	269:296	High-performance electromagnetic (EM) wave absorption and shielding materials integrating with flexibility, air permeability, and anti-fatigue characteristics are of great potential in portable and wearable electronics.
34325341	7	3	contain	possesses	1017:1025	arg2	performance					1051:1061	excellent EM absorption performance	1027:1061	excellent EM absorption performance	1027:1061	Benefiting from optimal impedance matching, strong conductive loss, as well as interfacial polarization, the CPF possesses excellent EM absorption performance.
34325341	7	3	contain	possesses	1017:1025	arg1	CPF					1013:1015	the CPF	1009:1015	the CPF	1009:1015	Benefiting from optimal impedance matching, strong conductive loss, as well as interfacial polarization, the CPF possesses excellent EM absorption performance.
34325341	10	4	theme	resistance	1474:1483	arg1	applicable					1502:1511	applicable	1502:1511	applicable	1502:1511	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	10	4	theme	resistance	1474:1483	arg1	merits					1417:1422	the merits	1413:1422	the merits	1413:1422	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	6	5	theme	electrical	840:849	arg1	conductivity					851:862	the electrical conductivity	836:862	the electrical conductivity	836:862	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs a conductive network, and the electrical conductivity can be adjusted by polymerization time.
34325341	1	6	theme	wave	177:180	arg1	absorption					182:191	High-performance electromagnetic (EM) wave absorption	139:191	High-performance electromagnetic (EM) wave absorption	139:191	High-performance electromagnetic (EM) wave absorption and shielding materials integrating with flexibility, air permeability, and anti-fatigue characteristics are of great potential in portable and wearable electronics.
34325341	0	7	theme	shielding	101:109	arg1	applications					125:136	microwave shielding and absorbing applications	91:136	microwave shielding and absorbing applications	91:136	A breathable and flexible fiber cloth based on cellulose/polyaniline cellular membrane for microwave shielding and absorbing applications.
34325341	10	8	theme	wearable	1517:1524	arg1	devices					1526:1532	wearable devices	1517:1532	wearable devices	1517:1532	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	8	9	theme	loss	1087:1090	arg1	-49.24 dB					1109:1117	-49.24 dB	1109:1117	-49.24 dB	1109:1117	The minimum reflection loss (RLmin) value is -49.24 dB, and the effective absorption bandwidth (RL < -10 dB, fe) reaches 6.90 GHz.
34325341	8	9	theme	loss	1087:1090	arg1	value					1100:1104	The minimum reflection loss (RLmin) value	1064:1104	The minimum reflection loss (RLmin) value	1064:1104	The minimum reflection loss (RLmin) value is -49.24 dB, and the effective absorption bandwidth (RL < -10 dB, fe) reaches 6.90 GHz.
34325341	10	10	theme	CPF	1396:1398	arg1	fabrics					1400:1406	the lightweight CPF fabrics	1380:1406	the lightweight CPF fabrics	1380:1406	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	10	11	contain	have	1408:1411	arg1	fabrics					1400:1406	the lightweight CPF fabrics	1380:1406	the lightweight CPF fabrics	1380:1406	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	10	11	contain	have	1408:1411	arg2	merits					1417:1422	the merits	1413:1422	the merits	1413:1422	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	10	11	contain	have	1408:1411	arg2	applicable					1502:1511	applicable	1502:1511	applicable	1502:1511	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	0	12	theme	microwave	91:99	arg1	applications					125:136	microwave shielding and absorbing applications	91:136	microwave shielding and absorbing applications	91:136	A breathable and flexible fiber cloth based on cellulose/polyaniline cellular membrane for microwave shielding and absorbing applications.
34325341	5	13	theme	CF	678:679	arg1	surface					681:687	the CF surface	674:687	the CF surface	674:687	Then, conductive polyaniline (PANI) was deposited on the CF surface via a facile in-situ polymerization process.
34325341	5	14	theme	conductive	627:636	arg1	PANI					651:654	PANI	651:654	PANI	651:654	Then, conductive polyaniline (PANI) was deposited on the CF surface via a facile in-situ polymerization process.
34325341	5	14	theme	conductive	627:636	arg1	polyaniline					638:648	conductive polyaniline	627:648	conductive polyaniline (PANI)	627:655	Then, conductive polyaniline (PANI) was deposited on the CF surface via a facile in-situ polymerization process.
34325341	0	15	theme	absorbing	115:123	arg1	applications					125:136	microwave shielding and absorbing applications	91:136	microwave shielding and absorbing applications	91:136	A breathable and flexible fiber cloth based on cellulose/polyaniline cellular membrane for microwave shielding and absorbing applications.
34325341	9	16	theme	34.93 dB	1332:1339	arg1	SE					1325:1326	SE	1325:1326	SE	1325:1326	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	9	16	theme	34.93 dB	1332:1339	arg1	efficiency					1313:1322	shielding efficiency	1303:1322	shielding efficiency (SE) of 34.93 dB in the whole X band	1303:1359	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	8	17	theme	RLmin	1093:1097	arg1	-49.24 dB					1109:1117	-49.24 dB	1109:1117	-49.24 dB	1109:1117	The minimum reflection loss (RLmin) value is -49.24 dB, and the effective absorption bandwidth (RL < -10 dB, fe) reaches 6.90 GHz.
34325341	8	17	theme	RLmin	1093:1097	arg1	value					1100:1104	The minimum reflection loss (RLmin) value	1064:1104	The minimum reflection loss (RLmin) value	1064:1104	The minimum reflection loss (RLmin) value is -49.24 dB, and the effective absorption bandwidth (RL < -10 dB, fe) reaches 6.90 GHz.
34325341	7	18	theme	interfacial	983:993	arg1	polarization					995:1006	interfacial polarization	983:1006	optimal impedance matching, strong conductive loss, as well as interfacial polarization	920:1006	Benefiting from optimal impedance matching, strong conductive loss, as well as interfacial polarization, the CPF possesses excellent EM absorption performance.
34325341	9	19	theme	whole	1348:1352	arg1	band					1356:1359	the whole X band	1344:1359	the whole X band	1344:1359	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	3	20	theme	heavy	471:475	arg1	weight					477:482	heavy weight	471:482	heavy weight	471:482	However, the shortcomings of heavy weight and easy corrosion hamper its application.
34325341	4	21	theme	electrospinning	593:607	arg1	technology					609:618	electrospinning technology	593:618	electrospinning technology	593:618	In this work, the cellulose nanofiber (CF) fabric was prepared by electrospinning technology.
34325341	10	22	theme	mechanical	1427:1436	arg1	flexibility					1438:1448	mechanical flexibility	1427:1448	mechanical flexibility	1427:1448	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	2	23	dep	metal	406:410	arg1	coatings					421:428	coatings	421:428	coatings	421:428	These materials usually prepared by depositing metal or alloy coatings on fabrics.
34325341	6	24	dep	network	823:829	arg1	constructs					799:808	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs	734:808	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs	734:808	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs a conductive network, and the electrical conductivity can be adjusted by polymerization time.
34325341	3	25	theme	weight	477:482	arg1	shortcomings					455:466	the shortcomings	451:466	the shortcomings of heavy weight and easy corrosion	451:501	However, the shortcomings of heavy weight and easy corrosion hamper its application.
34325341	0	26	theme	breathable	2:11	arg1	cloth					32:36	A breathable and flexible fiber cloth	0:36	A breathable and flexible fiber cloth	0:36	A breathable and flexible fiber cloth based on cellulose/polyaniline cellular membrane for microwave shielding and absorbing applications.
34325341	8	27	theme	reflection	1076:1085	arg1	-49.24 dB					1109:1117	-49.24 dB	1109:1117	-49.24 dB	1109:1117	The minimum reflection loss (RLmin) value is -49.24 dB, and the effective absorption bandwidth (RL < -10 dB, fe) reaches 6.90 GHz.
34325341	8	27	theme	reflection	1076:1085	arg1	value					1100:1104	The minimum reflection loss (RLmin) value	1064:1104	The minimum reflection loss (RLmin) value	1064:1104	The minimum reflection loss (RLmin) value is -49.24 dB, and the effective absorption bandwidth (RL < -10 dB, fe) reaches 6.90 GHz.
34325341	6	28	theme	conductive	812:821	arg1	network					823:829	a conductive network	810:829	a conductive network	810:829	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs a conductive network, and the electrical conductivity can be adjusted by polymerization time.
34325341	1	29	theme	shielding	197:205	arg1	materials					207:215	shielding materials	197:215	shielding materials integrating with flexibility, air permeability, and anti-fatigue characteristics	197:296	High-performance electromagnetic (EM) wave absorption and shielding materials integrating with flexibility, air permeability, and anti-fatigue characteristics are of great potential in portable and wearable electronics.
34325341	1	30	theme	great	305:309	arg1	potential					311:319	great potential	305:319	great potential	305:319	High-performance electromagnetic (EM) wave absorption and shielding materials integrating with flexibility, air permeability, and anti-fatigue characteristics are of great potential in portable and wearable electronics.
34325341	1	31	from	potential	311:319	arg1	electronics					346:356	portable and wearable electronics	324:356	portable and wearable electronics	324:356	High-performance electromagnetic (EM) wave absorption and shielding materials integrating with flexibility, air permeability, and anti-fatigue characteristics are of great potential in portable and wearable electronics.
34325341	9	32	theme	outstanding	1230:1240	arg1	capability					1287:1296	outstanding electromagnetic interference (EMI) shielding capability	1230:1296	outstanding electromagnetic interference (EMI) shielding capability	1230:1296	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	9	33	from	band	1356:1359	arg1	SE					1325:1326	SE	1325:1326	SE	1325:1326	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	9	33	from	band	1356:1359	arg1	efficiency					1313:1322	shielding efficiency	1303:1322	shielding efficiency (SE) of 34.93 dB in the whole X band	1303:1359	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	10	34	theme	flexibility	1438:1448	arg1	applicable					1502:1511	applicable	1502:1511	applicable	1502:1511	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	10	34	theme	flexibility	1438:1448	arg1	merits					1417:1422	the merits	1413:1422	the merits	1413:1422	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	10	35	theme	breathability	1451:1463	arg1	applicable					1502:1511	applicable	1502:1511	applicable	1502:1511	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	10	35	theme	breathability	1451:1463	arg1	merits					1417:1422	the merits	1413:1422	the merits	1413:1422	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	0	36	theme	flexible	17:24	arg1	cloth					32:36	A breathable and flexible fiber cloth	0:36	A breathable and flexible fiber cloth	0:36	A breathable and flexible fiber cloth based on cellulose/polyaniline cellular membrane for microwave shielding and absorbing applications.
34325341	9	37	theme	X	1354:1354	arg1	band					1356:1359	the whole X band	1344:1359	the whole X band	1344:1359	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	5	38	theme	in-situ	702:708	arg1	process					725:731	a facile in-situ polymerization process	693:731	a facile in-situ polymerization process	693:731	Then, conductive polyaniline (PANI) was deposited on the CF surface via a facile in-situ polymerization process.
34325341	7	39	dep	impedance	928:936	arg1	loss					966:969	strong conductive loss	948:969	strong conductive loss	948:969	Benefiting from optimal impedance matching, strong conductive loss, as well as interfacial polarization, the CPF possesses excellent EM absorption performance.
34325341	8	40	dep	bandwidth	1149:1157	arg1	fe					1173:1174	fe	1173:1174	fe	1173:1174	The minimum reflection loss (RLmin) value is -49.24 dB, and the effective absorption bandwidth (RL < -10 dB, fe) reaches 6.90 GHz.
34325341	8	40	dep	bandwidth	1149:1157	arg1	RL < -10 dB					1160:1170	RL < -10 dB	1160:1170	RL < -10 dB	1160:1170	The minimum reflection loss (RLmin) value is -49.24 dB, and the effective absorption bandwidth (RL < -10 dB, fe) reaches 6.90 GHz.
34325341	3	41	theme	corrosion	493:501	arg1	shortcomings					455:466	the shortcomings	451:466	the shortcomings of heavy weight and easy corrosion	451:501	However, the shortcomings of heavy weight and easy corrosion hamper its application.
34325341	7	42	theme	excellent	1027:1035	arg1	performance					1051:1061	excellent EM absorption performance	1027:1061	excellent EM absorption performance	1027:1061	Benefiting from optimal impedance matching, strong conductive loss, as well as interfacial polarization, the CPF possesses excellent EM absorption performance.
34325341	5	43	theme	polymerization	710:723	arg1	process					725:731	a facile in-situ polymerization process	693:731	a facile in-situ polymerization process	693:731	Then, conductive polyaniline (PANI) was deposited on the CF surface via a facile in-situ polymerization process.
34325341	9	44	theme	interference	1258:1269	arg1	capability					1287:1296	outstanding electromagnetic interference (EMI) shielding capability	1230:1296	outstanding electromagnetic interference (EMI) shielding capability	1230:1296	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	1	45	theme	portable	324:331	arg1	electronics					346:356	portable and wearable electronics	324:356	portable and wearable electronics	324:356	High-performance electromagnetic (EM) wave absorption and shielding materials integrating with flexibility, air permeability, and anti-fatigue characteristics are of great potential in portable and wearable electronics.
34325341	0	46	theme	fiber	26:30	arg1	cloth					32:36	A breathable and flexible fiber cloth	0:36	A breathable and flexible fiber cloth	0:36	A breathable and flexible fiber cloth based on cellulose/polyaniline cellular membrane for microwave shielding and absorbing applications.
34325341	4	47	theme	nanofiber	555:563	arg1	fabric					570:575	the cellulose nanofiber (CF) fabric	541:575	the cellulose nanofiber (CF) fabric	541:575	In this work, the cellulose nanofiber (CF) fabric was prepared by electrospinning technology.
34325341	6	48	theme	polymerization	883:896	arg1	time					898:901	polymerization time	883:901	polymerization time	883:901	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs a conductive network, and the electrical conductivity can be adjusted by polymerization time.
34325341	6	49	theme	composite	789:797	arg1	constructs					799:808	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs	734:808	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs	734:808	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs a conductive network, and the electrical conductivity can be adjusted by polymerization time.
34325341	3	50	theme	easy	488:491	arg1	corrosion					493:501	easy corrosion	488:501	easy corrosion	488:501	However, the shortcomings of heavy weight and easy corrosion hamper its application.
34325341	9	51	from	efficiency	1313:1322	arg1	band					1356:1359	the whole X band	1344:1359	the whole X band	1344:1359	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	1	52	theme	wearable	337:344	arg1	electronics					346:356	portable and wearable electronics	324:356	portable and wearable electronics	324:356	High-performance electromagnetic (EM) wave absorption and shielding materials integrating with flexibility, air permeability, and anti-fatigue characteristics are of great potential in portable and wearable electronics.
34325341	8	53	theme	effective	1128:1136	arg1	bandwidth					1149:1157	the effective absorption bandwidth	1124:1157	the effective absorption bandwidth (RL < -10 dB, fe)	1124:1175	The minimum reflection loss (RLmin) value is -49.24 dB, and the effective absorption bandwidth (RL < -10 dB, fe) reaches 6.90 GHz.
34325341	4	54	theme	CF	566:567	arg1	fabric					570:575	the cellulose nanofiber (CF) fabric	541:575	the cellulose nanofiber (CF) fabric	541:575	In this work, the cellulose nanofiber (CF) fabric was prepared by electrospinning technology.
34325341	10	55	theme	wash	1469:1472	arg1	resistance					1474:1483	wash resistance	1469:1483	wash resistance	1469:1483	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	9	56	theme	shielding	1277:1285	arg1	capability					1287:1296	outstanding electromagnetic interference (EMI) shielding capability	1230:1296	outstanding electromagnetic interference (EMI) shielding capability	1230:1296	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	7	57	theme	EM	1037:1038	arg1	performance					1051:1061	excellent EM absorption performance	1027:1061	excellent EM absorption performance	1027:1061	Benefiting from optimal impedance matching, strong conductive loss, as well as interfacial polarization, the CPF possesses excellent EM absorption performance.
34325341	9	58	theme	EMI	1272:1274	arg1	capability					1287:1296	outstanding electromagnetic interference (EMI) shielding capability	1230:1296	outstanding electromagnetic interference (EMI) shielding capability	1230:1296	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	7	59	theme	strong	948:953	arg1	loss					966:969	strong conductive loss	948:969	strong conductive loss	948:969	Benefiting from optimal impedance matching, strong conductive loss, as well as interfacial polarization, the CPF possesses excellent EM absorption performance.
34325341	9	60	theme	electromagnetic	1242:1256	arg1	capability					1287:1296	outstanding electromagnetic interference (EMI) shielding capability	1230:1296	outstanding electromagnetic interference (EMI) shielding capability	1230:1296	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	7	61	theme	absorption	1040:1049	arg1	performance					1051:1061	excellent EM absorption performance	1027:1061	excellent EM absorption performance	1027:1061	Benefiting from optimal impedance matching, strong conductive loss, as well as interfacial polarization, the CPF possesses excellent EM absorption performance.
34325341	1	62	theme	High-performance	139:154	arg1	absorption					182:191	High-performance electromagnetic (EM) wave absorption	139:191	High-performance electromagnetic (EM) wave absorption	139:191	High-performance electromagnetic (EM) wave absorption and shielding materials integrating with flexibility, air permeability, and anti-fatigue characteristics are of great potential in portable and wearable electronics.
34325341	7	63	theme	conductive	955:964	arg1	loss					966:969	strong conductive loss	948:969	strong conductive loss	948:969	Benefiting from optimal impedance matching, strong conductive loss, as well as interfacial polarization, the CPF possesses excellent EM absorption performance.
34325341	1	64	theme	air	247:249	arg1	permeability					251:262	air permeability	247:262	air permeability	247:262	High-performance electromagnetic (EM) wave absorption and shielding materials integrating with flexibility, air permeability, and anti-fatigue characteristics are of great potential in portable and wearable electronics.
34325341	5	65	theme	facile	695:700	arg1	process					725:731	a facile in-situ polymerization process	693:731	a facile in-situ polymerization process	693:731	Then, conductive polyaniline (PANI) was deposited on the CF surface via a facile in-situ polymerization process.
34325341	6	66	theme	nanofiber	773:781	arg1	constructs					799:808	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs	734:808	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs	734:808	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs a conductive network, and the electrical conductivity can be adjusted by polymerization time.
34325341	1	67	theme	electromagnetic	156:170	arg1	absorption					182:191	High-performance electromagnetic (EM) wave absorption	139:191	High-performance electromagnetic (EM) wave absorption	139:191	High-performance electromagnetic (EM) wave absorption and shielding materials integrating with flexibility, air permeability, and anti-fatigue characteristics are of great potential in portable and wearable electronics.
34325341	7	68	theme	matching	938:945	arg1	impedance					928:936	optimal impedance matching, strong conductive loss,	920:970	impedance	928:936	Benefiting from optimal impedance matching, strong conductive loss, as well as interfacial polarization, the CPF possesses excellent EM absorption performance.
34325341	0	69	theme	cellular	69:76	arg1	membrane					78:85	cellulose/polyaniline cellular membrane	47:85	cellulose/polyaniline cellular membrane for microwave shielding and absorbing applications	47:136	A breathable and flexible fiber cloth based on cellulose/polyaniline cellular membrane for microwave shielding and absorbing applications.
34325341	9	70	theme	shielding	1303:1311	arg1	SE					1325:1326	SE	1325:1326	SE	1325:1326	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	9	70	theme	shielding	1303:1311	arg1	efficiency					1313:1322	shielding efficiency	1303:1322	shielding efficiency (SE) of 34.93 dB in the whole X band	1303:1359	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	6	71	theme	cellulose/polyaniline	751:771	arg1	CPF					784:786	CPF	784:786	CPF	784:786	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs a conductive network, and the electrical conductivity can be adjusted by polymerization time.
34325341	6	71	theme	cellulose/polyaniline	751:771	arg1	nanofiber					773:781	The interweaving cellulose/polyaniline nanofiber	734:781	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs	734:808	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs a conductive network, and the electrical conductivity can be adjusted by polymerization time.
34325341	10	72	theme	lightweight	1384:1394	arg1	fabrics					1400:1406	the lightweight CPF fabrics	1380:1406	the lightweight CPF fabrics	1380:1406	Most importantly, the lightweight CPF fabrics have the merits of mechanical flexibility, breathability and wash resistance, which is highly applicable for wearable devices.
34325341	0	73	theme	cellulose/polyaniline	47:67	arg1	membrane					78:85	cellulose/polyaniline cellular membrane	47:85	cellulose/polyaniline cellular membrane for microwave shielding and absorbing applications	47:136	A breathable and flexible fiber cloth based on cellulose/polyaniline cellular membrane for microwave shielding and absorbing applications.
34325341	9	74	from	34.93 dB	1332:1339	arg1	band					1356:1359	the whole X band	1344:1359	the whole X band	1344:1359	Furthermore, the CPF also exhibits outstanding electromagnetic interference (EMI) shielding capability with shielding efficiency (SE) of 34.93 dB in the whole X band.
34325341	6	75	theme	interweaving	738:749	arg1	CPF					784:786	CPF	784:786	CPF	784:786	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs a conductive network, and the electrical conductivity can be adjusted by polymerization time.
34325341	6	75	theme	interweaving	738:749	arg1	nanofiber					773:781	The interweaving cellulose/polyaniline nanofiber	734:781	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs	734:808	The interweaving cellulose/polyaniline nanofiber (CPF) composite constructs a conductive network, and the electrical conductivity can be adjusted by polymerization time.
34325341	1	76	theme	EM	173:174	arg1	absorption					182:191	High-performance electromagnetic (EM) wave absorption	139:191	High-performance electromagnetic (EM) wave absorption	139:191	High-performance electromagnetic (EM) wave absorption and shielding materials integrating with flexibility, air permeability, and anti-fatigue characteristics are of great potential in portable and wearable electronics.
34325341	7	77	theme	optimal	920:926	arg1	impedance					928:936	optimal impedance matching, strong conductive loss,	920:970	impedance	928:936	Benefiting from optimal impedance matching, strong conductive loss, as well as interfacial polarization, the CPF possesses excellent EM absorption performance.
34325341	4	78	theme	cellulose	545:553	arg1	fabric					570:575	the cellulose nanofiber (CF) fabric	541:575	the cellulose nanofiber (CF) fabric	541:575	In this work, the cellulose nanofiber (CF) fabric was prepared by electrospinning technology.
33590334	5	0	theme	composite	684:692	arg1	films					694:698	composite films	684:698	composite films	684:698	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus show that the composite chitosan films have better antibacterial activity.
33590334	6	1	theme	additive	1045:1052	arg1	ingredient					1054:1063	an antibacterial additive ingredient	1028:1063	an antibacterial additive ingredient	1028:1063	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	1	theme	additive	1045:1052	arg1	application					1013:1023	potent application	1006:1023	potent application	1006:1023	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	1	theme	additive	1045:1052	arg1	activity					993:1000	better bacteriostatic activity	971:1000	better bacteriostatic activity	971:1000	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	4	2	theme	electron	525:532	arg1	microscopy					534:543	scanning electron microscopy	516:543	scanning electron microscopy	516:543	The films were characterized by scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, and mechanical analysis.
33590334	6	3	theme	oxide	865:869	arg1	particles					871:879	50 nm zinc oxide particles	854:879	50 nm zinc oxide particles	854:879	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	5	4	theme	chitosan	775:782	arg1	films					784:788	the composite chitosan films	761:788	the composite chitosan films	761:788	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus show that the composite chitosan films have better antibacterial activity.
33590334	4	5	theme	scanning	516:523	arg1	microscopy					534:543	scanning electron microscopy	516:543	scanning electron microscopy	516:543	The films were characterized by scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, and mechanical analysis.
33590334	6	6	theme	bacteriostatic	978:991	arg1	activity					993:1000	better bacteriostatic activity	971:1000	better bacteriostatic activity	971:1000	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	6	theme	bacteriostatic	978:991	arg1	application					1013:1023	potent application	1006:1023	potent application	1006:1023	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	6	theme	bacteriostatic	978:991	arg1	ingredient					1054:1063	an antibacterial additive ingredient	1028:1063	an antibacterial additive ingredient	1028:1063	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	5	7	theme	Antimicrobial	631:643	arg1	assay					645:649	Antimicrobial assay	631:649	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus	631:749	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus show that the composite chitosan films have better antibacterial activity.
33590334	6	8	contain	containing	835:844	arg2	particles					871:879	50 nm zinc oxide particles	854:879	50 nm zinc oxide particles	854:879	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	8	contain	containing	835:844	arg1	film					830:833	The film	826:833	The film containing 0.3% of 50 nm zinc oxide particles	826:879	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	8	contain	containing	835:844	arg2	%					849:849	0.3%	846:849	0.3% of 50 nm zinc oxide particles	846:879	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	9	theme	50 nm	854:858	arg1	oxide					865:869	50 nm zinc oxide	854:869	50 nm zinc oxide particles	854:879	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	4	10	theme	mechanical	610:619	arg1	analysis					621:628	mechanical analysis	610:628	mechanical analysis	610:628	The films were characterized by scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, and mechanical analysis.
33590334	3	11	theme	chitosan	360:367	arg1	films					379:383	chitosan composite films	360:383	chitosan composite films	360:383	To improve the performance of chitosan film, in this work, chitosan composite films were prepared by incorporating different sizes of zinc oxide particles of 5 μm, 100 nm, and 50 nm.
33590334	5	12	contain	have	790:793	arg2	activity					816:823	better antibacterial activity	795:823	better antibacterial activity	795:823	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus show that the composite chitosan films have better antibacterial activity.
33590334	5	12	contain	have	790:793	arg1	films					784:788	the composite chitosan films	761:788	the composite chitosan films	761:788	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus show that the composite chitosan films have better antibacterial activity.
33590334	3	13	theme	50 nm	477:481	arg1	particles					446:454	zinc oxide particles	435:454	zinc oxide particles of 5 μm, 100 nm, and 50 nm	435:481	To improve the performance of chitosan film, in this work, chitosan composite films were prepared by incorporating different sizes of zinc oxide particles of 5 μm, 100 nm, and 50 nm.
33590334	6	14	contain	have	966:969	arg1	sizes					938:942	smaller sizes	930:942	smaller sizes of nano-ZnO particles	930:964	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	14	contain	have	966:969	arg2	ingredient					1054:1063	an antibacterial additive ingredient	1028:1063	an antibacterial additive ingredient	1028:1063	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	14	contain	have	966:969	arg2	application					1013:1023	potent application	1006:1023	potent application	1006:1023	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	14	contain	have	966:969	arg2	activity					993:1000	better bacteriostatic activity	971:1000	better bacteriostatic activity	971:1000	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	3	15	theme	5 μm	459:462	arg1	particles					446:454	zinc oxide particles	435:454	zinc oxide particles of 5 μm, 100 nm, and 50 nm	435:481	To improve the performance of chitosan film, in this work, chitosan composite films were prepared by incorporating different sizes of zinc oxide particles of 5 μm, 100 nm, and 50 nm.
33590334	3	16	theme	composite	369:377	arg1	films					379:383	chitosan composite films	360:383	chitosan composite films	360:383	To improve the performance of chitosan film, in this work, chitosan composite films were prepared by incorporating different sizes of zinc oxide particles of 5 μm, 100 nm, and 50 nm.
33590334	6	17	theme	smaller	930:936	arg1	sizes					938:942	smaller sizes	930:942	smaller sizes of nano-ZnO particles	930:964	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	0	18	theme	composite	54:62	arg1	film					64:67	chitosan/Nano-ZnO composite film	36:67	chitosan/Nano-ZnO composite film with antimicrobial activity	36:95	Preparation and characterization of chitosan/Nano-ZnO composite film with antimicrobial activity.
33590334	6	19	theme	antibacterial	1031:1043	arg1	ingredient					1054:1063	an antibacterial additive ingredient	1028:1063	an antibacterial additive ingredient	1028:1063	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	19	theme	antibacterial	1031:1043	arg1	application					1013:1023	potent application	1006:1023	potent application	1006:1023	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	19	theme	antibacterial	1031:1043	arg1	activity					993:1000	better bacteriostatic activity	971:1000	better bacteriostatic activity	971:1000	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	20	theme	particles	956:964	arg1	sizes					938:942	smaller sizes	930:942	smaller sizes of nano-ZnO particles	930:964	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	3	21	theme	particles	446:454	arg1	sizes					426:430	different sizes	416:430	different sizes of zinc oxide particles of 5 μm, 100 nm, and 50 nm	416:481	To improve the performance of chitosan film, in this work, chitosan composite films were prepared by incorporating different sizes of zinc oxide particles of 5 μm, 100 nm, and 50 nm.
33590334	3	22	theme	different	416:424	arg1	sizes					426:430	different sizes	416:430	different sizes of zinc oxide particles of 5 μm, 100 nm, and 50 nm	416:481	To improve the performance of chitosan film, in this work, chitosan composite films were prepared by incorporating different sizes of zinc oxide particles of 5 μm, 100 nm, and 50 nm.
33590334	4	23	theme	Fourier-transform	565:581	arg1	spectroscopy					592:603	Fourier-transform infrared spectroscopy	565:603	Fourier-transform infrared spectroscopy	565:603	The films were characterized by scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, and mechanical analysis.
33590334	5	24	theme	CTS/nano-ZnO	671:682	arg1	assay					645:649	Antimicrobial assay	631:649	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus	631:749	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus show that the composite chitosan films have better antibacterial activity.
33590334	1	25	theme	promising	110:118	arg1	material					120:127	promising material	110:127	promising material for making food packaging film with antimicrobial activity	110:186	Chitosan is promising material for making food packaging film with antimicrobial activity.
33590334	2	26	dep	solubility	289:298	arg1	higher					276:281	higher	276:281	higher	276:281	However, chitosan film usually has limited mechanical and antimicrobial properties and higher water solubility.
33590334	6	27	theme	best	892:895	arg1	rate					908:911	the best inhibition rate	888:911	the best inhibition rate	888:911	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	2	28	contain	has	220:222	arg1	chitosan					198:205	chitosan film	198:210	chitosan film	198:210	However, chitosan film usually has limited mechanical and antimicrobial properties and higher water solubility.
33590334	2	28	contain	has	220:222	arg2	properties					261:270	limited mechanical and antimicrobial properties	224:270	limited mechanical and antimicrobial properties	224:270	However, chitosan film usually has limited mechanical and antimicrobial properties and higher water solubility.
33590334	3	29	theme	zinc	435:438	arg1	particles					446:454	zinc oxide particles	435:454	zinc oxide particles of 5 μm, 100 nm, and 50 nm	435:481	To improve the performance of chitosan film, in this work, chitosan composite films were prepared by incorporating different sizes of zinc oxide particles of 5 μm, 100 nm, and 50 nm.
33590334	4	30	theme	infrared	583:590	arg1	spectroscopy					592:603	Fourier-transform infrared spectroscopy	565:603	Fourier-transform infrared spectroscopy	565:603	The films were characterized by scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, and mechanical analysis.
33590334	5	31	theme	composite	765:773	arg1	films					784:788	the composite chitosan films	761:788	the composite chitosan films	761:788	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus show that the composite chitosan films have better antibacterial activity.
33590334	3	32	theme	100 nm	465:470	arg1	particles					446:454	zinc oxide particles	435:454	zinc oxide particles of 5 μm, 100 nm, and 50 nm	435:481	To improve the performance of chitosan film, in this work, chitosan composite films were prepared by incorporating different sizes of zinc oxide particles of 5 μm, 100 nm, and 50 nm.
33590334	0	33	theme	chitosan/Nano-ZnO	36:52	arg1	film					64:67	chitosan/Nano-ZnO composite film	36:67	chitosan/Nano-ZnO composite film with antimicrobial activity	36:95	Preparation and characterization of chitosan/Nano-ZnO composite film with antimicrobial activity.
33590334	6	34	theme	potent	1006:1011	arg1	ingredient					1054:1063	an antibacterial additive ingredient	1028:1063	an antibacterial additive ingredient	1028:1063	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	34	theme	potent	1006:1011	arg1	application					1013:1023	potent application	1006:1023	potent application	1006:1023	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	34	theme	potent	1006:1011	arg1	activity					993:1000	better bacteriostatic activity	971:1000	better bacteriostatic activity	971:1000	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	3	35	theme	oxide	440:444	arg1	particles					446:454	zinc oxide particles	435:454	zinc oxide particles of 5 μm, 100 nm, and 50 nm	435:481	To improve the performance of chitosan film, in this work, chitosan composite films were prepared by incorporating different sizes of zinc oxide particles of 5 μm, 100 nm, and 50 nm.
33590334	5	36	theme	better	795:800	arg1	activity					816:823	better antibacterial activity	795:823	better antibacterial activity	795:823	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus show that the composite chitosan films have better antibacterial activity.
33590334	6	37	theme	inhibition	897:906	arg1	rate					908:911	the best inhibition rate	888:911	the best inhibition rate	888:911	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	2	38	theme	antimicrobial	247:259	arg1	properties					261:270	limited mechanical and antimicrobial properties	224:270	limited mechanical and antimicrobial properties	224:270	However, chitosan film usually has limited mechanical and antimicrobial properties and higher water solubility.
33590334	0	39	theme	film	64:67	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of chitosan/Nano-ZnO composite film with antimicrobial activity.
33590334	0	39	theme	film	64:67	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of chitosan/Nano-ZnO composite film with antimicrobial activity.
33590334	2	40	theme	mechanical	232:241	arg1	properties					261:270	limited mechanical and antimicrobial properties	224:270	limited mechanical and antimicrobial properties	224:270	However, chitosan film usually has limited mechanical and antimicrobial properties and higher water solubility.
33590334	5	41	theme	chitosan	658:665	arg1	assay					645:649	Antimicrobial assay	631:649	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus	631:749	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus show that the composite chitosan films have better antibacterial activity.
33590334	1	42	theme	food	140:143	arg1	film					155:158	food packaging film	140:158	food packaging film	140:158	Chitosan is promising material for making food packaging film with antimicrobial activity.
33590334	4	43	theme	X-ray	546:550	arg1	diffraction					552:562	X-ray diffraction	546:562	X-ray diffraction	546:562	The films were characterized by scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, and mechanical analysis.
33590334	2	44	theme	limited	224:230	arg1	properties					261:270	limited mechanical and antimicrobial properties	224:270	limited mechanical and antimicrobial properties	224:270	However, chitosan film usually has limited mechanical and antimicrobial properties and higher water solubility.
33590334	6	45	theme	zinc	860:863	arg1	oxide					865:869	50 nm zinc oxide	854:869	50 nm zinc oxide particles	854:879	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	1	46	theme	packaging	145:153	arg1	film					155:158	food packaging film	140:158	food packaging film	140:158	Chitosan is promising material for making food packaging film with antimicrobial activity.
33590334	3	47	theme	chitosan	331:338	arg1	performance					316:326	the performance	312:326	the performance of chitosan film	312:343	To improve the performance of chitosan film, in this work, chitosan composite films were prepared by incorporating different sizes of zinc oxide particles of 5 μm, 100 nm, and 50 nm.
33590334	5	48	dep	chitosan	658:665	arg1	films					694:698	composite films	684:698	composite films	684:698	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus show that the composite chitosan films have better antibacterial activity.
33590334	5	48	dep	chitosan	658:665	arg1	the					654:656	the	654:656	the	654:656	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus show that the composite chitosan films have better antibacterial activity.
33590334	5	49	theme	antibacterial	802:814	arg1	activity					816:823	better antibacterial activity	795:823	better antibacterial activity	795:823	Antimicrobial assay of the chitosan and CTS/nano-ZnO composite films against Escherichia coli and Staphylococcus aureus show that the composite chitosan films have better antibacterial activity.
33590334	6	50	theme	particles	871:879	arg1	particles					871:879	50 nm zinc oxide particles	854:879	50 nm zinc oxide particles	854:879	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	50	theme	particles	871:879	arg1	%					849:849	0.3%	846:849	0.3% of 50 nm zinc oxide particles	846:879	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	2	51	theme	water	283:287	arg1	solubility					289:298	water solubility	283:298	water solubility	283:298	However, chitosan film usually has limited mechanical and antimicrobial properties and higher water solubility.
33590334	0	52	with	film	64:67	arg1	activity					88:95	antimicrobial activity	74:95	antimicrobial activity	74:95	Preparation and characterization of chitosan/Nano-ZnO composite film with antimicrobial activity.
33590334	6	53	theme	nano-ZnO	947:954	arg1	particles					956:964	nano-ZnO particles	947:964	nano-ZnO particles	947:964	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	0	54	theme	antimicrobial	74:86	arg1	activity					88:95	antimicrobial activity	74:95	antimicrobial activity	74:95	Preparation and characterization of chitosan/Nano-ZnO composite film with antimicrobial activity.
33590334	6	55	theme	better	971:976	arg1	activity					993:1000	better bacteriostatic activity	971:1000	better bacteriostatic activity	971:1000	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	55	theme	better	971:976	arg1	application					1013:1023	potent application	1006:1023	potent application	1006:1023	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	6	55	theme	better	971:976	arg1	ingredient					1054:1063	an antibacterial additive ingredient	1028:1063	an antibacterial additive ingredient	1028:1063	The film containing 0.3% of 50 nm zinc oxide particles showed the best inhibition rate, suggesting that smaller sizes of nano-ZnO particles have better bacteriostatic activity and potent application as an antibacterial additive ingredient.
33590334	1	56	theme	antimicrobial	165:177	arg1	activity					179:186	antimicrobial activity	165:186	antimicrobial activity	165:186	Chitosan is promising material for making food packaging film with antimicrobial activity.
33838198	8	0	contain	had	1250:1252	arg2	values					1282:1287	higher ζ-potential absolute values	1254:1287	higher ζ-potential absolute values	1254:1287	Compared with native β-CD particles, these hybrid particles had higher ζ-potential absolute values, and the SBP could also increase the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs.
33838198	8	0	contain	had	1250:1252	arg1	particles					1240:1248	these hybrid particles	1227:1248	these hybrid particles	1227:1248	Compared with native β-CD particles, these hybrid particles had higher ζ-potential absolute values, and the SBP could also increase the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs.
33838198	1	1	theme	internal	159:166	arg1	HIPEs					185:189	Food-grade Pickering high internal phase emulsions (HIPEs)	133:190	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP)	133:267	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP) were fabricated for the first time.
33838198	8	2	dep	formation	1383:1391	arg1	the					1379:1381	the	1379:1381	the	1379:1381	Compared with native β-CD particles, these hybrid particles had higher ζ-potential absolute values, and the SBP could also increase the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs.
33838198	1	3	theme	phase	168:172	arg1	HIPEs					185:189	Food-grade Pickering high internal phase emulsions (HIPEs)	133:190	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP)	133:267	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP) were fabricated for the first time.
33838198	6	4	theme	W	900:900	arg1	%					907:907	W ≥ 1.0%	900:907	W ≥ 1.0%	900:907	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	0	5	theme	β-cyclodextrin	95:108	arg1	mixture					84:90	the mixture	80:90	the mixture of β-cyclodextrin and sugar beet pectin	80:130	Fabrication of food-grade Pickering high internal phase emulsions stabilized by the mixture of β-cyclodextrin and sugar beet pectin.
33838198	5	6	dep	ratio	764:768	arg1	Rc/s					786:789	Rc/s	786:789	Rc/s	786:789	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	3	7	theme	formation	531:539	arg1	mechanism					541:549	the formation mechanism	527:549	the formation mechanism	527:549	The corresponding hybrid particles were also separated and characterized to reveal the formation mechanism.
33838198	4	8	theme	volume	645:650	arg1	φ					662:662	φ	662:662	φ	662:662	The results indicated that the mixture could induce the formation of HIPEs with an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature.
33838198	4	8	theme	volume	645:650	arg1	fraction					652:659	an oil phase volume fraction	632:659	an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature	632:735	The results indicated that the mixture could induce the formation of HIPEs with an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature.
33838198	1	9	theme	sugar	245:249	arg1	SBP					264:266	SBP	264:266	SBP	264:266	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP) were fabricated for the first time.
33838198	1	9	theme	sugar	245:249	arg1	pectin					256:261	sugar beet pectin	245:261	sugar beet pectin (SBP)	245:267	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP) were fabricated for the first time.
33838198	8	10	theme	higher	1254:1259	arg1	values					1282:1287	higher ζ-potential absolute values	1254:1287	higher ζ-potential absolute values	1254:1287	Compared with native β-CD particles, these hybrid particles had higher ζ-potential absolute values, and the SBP could also increase the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs.
33838198	6	11	theme	protection	1031:1040	arg1	effects					1042:1048	lutein protection effects	1024:1048	lutein protection effects	1024:1048	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	4	12	theme	room	720:723	arg1	temperature					725:735	room temperature	720:735	room temperature	720:735	The results indicated that the mixture could induce the formation of HIPEs with an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature.
33838198	7	13	theme	β-CD	1123:1126	arg1	particles					1128:1136	β-CD particles	1123:1136	β-CD particles	1123:1136	The spectral analysis suggested that SBP could adhere to the surface of β-CD particles to form hybrid particles during the homogenization.
33838198	4	14	theme	one-step	680:687	arg1	process					709:715	a one-step high-speed shearing process	678:715	a one-step high-speed shearing process	678:715	The results indicated that the mixture could induce the formation of HIPEs with an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature.
33838198	1	15	theme	beet	251:254	arg1	SBP					264:266	SBP	264:266	SBP	264:266	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP) were fabricated for the first time.
33838198	1	15	theme	beet	251:254	arg1	pectin					256:261	sugar beet pectin	245:261	sugar beet pectin (SBP)	245:267	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP) were fabricated for the first time.
33838198	0	16	theme	sugar	114:118	arg1	beet					120:123	sugar beet	114:123	sugar beet	114:123	Fabrication of food-grade Pickering high internal phase emulsions stabilized by the mixture of β-cyclodextrin and sugar beet pectin.
33838198	7	17	theme	particles	1128:1136	arg1	surface					1112:1118	the surface	1108:1118	the surface of β-CD particles	1108:1136	The spectral analysis suggested that SBP could adhere to the surface of β-CD particles to form hybrid particles during the homogenization.
33838198	6	18	theme	higher	964:969	arg1	strengths					975:983	higher gel strengths	964:983	higher gel strengths	964:983	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	4	19	theme	HIPEs	621:625	arg1	formation					608:616	the formation	604:616	the formation of HIPEs	604:625	The results indicated that the mixture could induce the formation of HIPEs with an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature.
33838198	0	20	dep	β-cyclodextrin	95:108	arg1	pectin					125:130	pectin	125:130	pectin	125:130	Fabrication of food-grade Pickering high internal phase emulsions stabilized by the mixture of β-cyclodextrin and sugar beet pectin.
33838198	6	21	theme	smaller	942:948	arg1	droplets					954:961	smaller oil droplets	942:961	smaller oil droplets	942:961	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	1	22	theme	emulsions	174:182	arg1	HIPEs					185:189	Food-grade Pickering high internal phase emulsions (HIPEs)	133:190	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP)	133:267	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP) were fabricated for the first time.
33838198	5	23	theme	mass	759:762	arg1	composition					742:752	The composition	738:752	The composition (the mass ratio of β-CD to SBP, Rc/s)	738:790	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	5	23	theme	mass	759:762	arg1	ratio					764:768	the mass ratio	755:768	the mass ratio of β-CD to SBP	755:783	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	6	24	theme	better	986:991	arg1	stabilities					1008:1018	better centrifugation stabilities	986:1018	better centrifugation stabilities	986:1018	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	8	25	theme	hybrid	1233:1238	arg1	particles					1240:1248	these hybrid particles	1227:1248	these hybrid particles	1227:1248	Compared with native β-CD particles, these hybrid particles had higher ζ-potential absolute values, and the SBP could also increase the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs.
33838198	4	26	theme	phase	639:643	arg1	φ					662:662	φ	662:662	φ	662:662	The results indicated that the mixture could induce the formation of HIPEs with an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature.
33838198	4	26	theme	phase	639:643	arg1	fraction					652:659	an oil phase volume fraction	632:659	an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature	632:735	The results indicated that the mixture could induce the formation of HIPEs with an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature.
33838198	7	27	theme	spectral	1055:1062	arg1	analysis					1064:1071	The spectral analysis	1051:1071	The spectral analysis	1051:1071	The spectral analysis suggested that SBP could adhere to the surface of β-CD particles to form hybrid particles during the homogenization.
33838198	4	28	theme	shearing	700:707	arg1	process					709:715	a one-step high-speed shearing process	678:715	a one-step high-speed shearing process	678:715	The results indicated that the mixture could induce the formation of HIPEs with an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature.
33838198	7	29	theme	hybrid	1146:1151	arg1	particles					1153:1161	hybrid particles	1146:1161	hybrid particles	1146:1161	The spectral analysis suggested that SBP could adhere to the surface of β-CD particles to form hybrid particles during the homogenization.
33838198	2	30	theme	mechanical	348:357	arg1	properties					359:368	mechanical properties	348:368	mechanical properties	348:368	The factors affecting the microstructures, mechanical properties, and stabilities of the Pickering HIPEs were systematically investigated.
33838198	1	31	theme	pectin	256:261	arg1	mixture					208:214	a mixture	206:214	a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP)	206:267	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP) were fabricated for the first time.
33838198	4	32	theme	high-speed	689:698	arg1	process					709:715	a one-step high-speed shearing process	678:715	a one-step high-speed shearing process	678:715	The results indicated that the mixture could induce the formation of HIPEs with an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature.
33838198	2	33	theme	HIPEs	404:408	arg1	properties					359:368	mechanical properties	348:368	mechanical properties	348:368	The factors affecting the microstructures, mechanical properties, and stabilities of the Pickering HIPEs were systematically investigated.
33838198	2	33	theme	HIPEs	404:408	arg1	stabilities					375:385	stabilities	375:385	stabilities of the Pickering HIPEs	375:408	The factors affecting the microstructures, mechanical properties, and stabilities of the Pickering HIPEs were systematically investigated.
33838198	2	33	theme	HIPEs	404:408	arg1	microstructures					331:345	the microstructures	327:345	the microstructures	327:345	The factors affecting the microstructures, mechanical properties, and stabilities of the Pickering HIPEs were systematically investigated.
33838198	8	34	theme	HIPEs	1417:1421	arg1	properties					1397:1406	properties	1397:1406	properties	1397:1406	Compared with native β-CD particles, these hybrid particles had higher ζ-potential absolute values, and the SBP could also increase the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs.
33838198	8	34	theme	HIPEs	1417:1421	arg1	formation					1383:1391	formation	1383:1391	formation	1383:1391	Compared with native β-CD particles, these hybrid particles had higher ζ-potential absolute values, and the SBP could also increase the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs.
33838198	5	35	dep	formation	860:868	arg1	the					856:858	the	856:858	the	856:858	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	0	36	theme	food-grade	15:24	arg1	emulsions					56:64	food-grade Pickering high internal phase emulsions	15:64	food-grade Pickering high internal phase emulsions	15:64	Fabrication of food-grade Pickering high internal phase emulsions stabilized by the mixture of β-cyclodextrin and sugar beet pectin.
33838198	0	37	theme	beet	120:123	arg1	mixture					84:90	the mixture	80:90	the mixture of β-cyclodextrin and sugar beet pectin	80:130	Fabrication of food-grade Pickering high internal phase emulsions stabilized by the mixture of β-cyclodextrin and sugar beet pectin.
33838198	5	38	theme	mixture	821:827	arg1	concentration					796:808	concentration	796:808	concentration (W)	796:812	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	5	38	theme	mixture	821:827	arg1	composition					742:752	The composition	738:752	The composition (the mass ratio of β-CD to SBP, Rc/s)	738:790	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	5	38	theme	mixture	821:827	arg1	ratio					764:768	the mass ratio	755:768	the mass ratio of β-CD to SBP	755:783	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	5	38	theme	mixture	821:827	arg1	W					811:811	W	811:811	W	811:811	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	3	39	theme	corresponding	448:460	arg1	particles					469:477	The corresponding hybrid particles	444:477	The corresponding hybrid particles	444:477	The corresponding hybrid particles were also separated and characterized to reveal the formation mechanism.
33838198	0	40	theme	internal	41:48	arg1	emulsions					56:64	food-grade Pickering high internal phase emulsions	15:64	food-grade Pickering high internal phase emulsions	15:64	Fabrication of food-grade Pickering high internal phase emulsions stabilized by the mixture of β-cyclodextrin and sugar beet pectin.
33838198	5	41	theme	significant	833:843	arg1	effects					845:851	significant effects	833:851	significant effects	833:851	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	6	42	theme	centrifugation	993:1006	arg1	stabilities					1008:1018	better centrifugation stabilities	986:1018	better centrifugation stabilities	986:1018	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	4	43	theme	oil	635:637	arg1	φ					662:662	φ	662:662	φ	662:662	The results indicated that the mixture could induce the formation of HIPEs with an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature.
33838198	4	43	theme	oil	635:637	arg1	fraction					652:659	an oil phase volume fraction	632:659	an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature	632:735	The results indicated that the mixture could induce the formation of HIPEs with an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature.
33838198	0	44	theme	high	36:39	arg1	emulsions					56:64	food-grade Pickering high internal phase emulsions	15:64	food-grade Pickering high internal phase emulsions	15:64	Fabrication of food-grade Pickering high internal phase emulsions stabilized by the mixture of β-cyclodextrin and sugar beet pectin.
33838198	0	45	theme	Pickering	26:34	arg1	emulsions					56:64	food-grade Pickering high internal phase emulsions	15:64	food-grade Pickering high internal phase emulsions	15:64	Fabrication of food-grade Pickering high internal phase emulsions stabilized by the mixture of β-cyclodextrin and sugar beet pectin.
33838198	5	46	theme	β-CD	773:776	arg1	composition					742:752	The composition	738:752	The composition (the mass ratio of β-CD to SBP, Rc/s)	738:790	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	5	46	theme	β-CD	773:776	arg1	ratio					764:768	the mass ratio	755:768	the mass ratio of β-CD to SBP	755:783	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	0	47	theme	emulsions	56:64	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of food-grade Pickering high internal phase emulsions	0:64	Fabrication of food-grade Pickering high internal phase emulsions stabilized by the mixture of β-cyclodextrin and sugar beet pectin.
33838198	8	48	theme	phase	1351:1355	arg1	viscosity					1326:1334	the viscosity	1322:1334	the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs	1322:1421	Compared with native β-CD particles, these hybrid particles had higher ζ-potential absolute values, and the SBP could also increase the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs.
33838198	5	49	theme	HIPEs	888:892	arg1	properties					874:883	properties	874:883	properties	874:883	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	5	49	theme	HIPEs	888:892	arg1	formation					860:868	formation	860:868	formation	860:868	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	0	50	theme	phase	50:54	arg1	emulsions					56:64	food-grade Pickering high internal phase emulsions	15:64	food-grade Pickering high internal phase emulsions	15:64	Fabrication of food-grade Pickering high internal phase emulsions stabilized by the mixture of β-cyclodextrin and sugar beet pectin.
33838198	6	51	contain	had	938:940	arg2	droplets					954:961	smaller oil droplets	942:961	smaller oil droplets	942:961	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	6	51	contain	had	938:940	arg2	stabilities					1008:1018	better centrifugation stabilities	986:1018	better centrifugation stabilities	986:1018	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	6	51	contain	had	938:940	arg1	HIPEs					932:936	HIPEs	932:936	HIPEs	932:936	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	6	51	contain	had	938:940	arg2	strengths					975:983	higher gel strengths	964:983	higher gel strengths	964:983	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	6	51	contain	had	938:940	arg2	effects					1042:1048	lutein protection effects	1024:1048	lutein protection effects	1024:1048	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	8	52	theme	β-CD	1211:1214	arg1	particles					1216:1224	native β-CD particles	1204:1224	native β-CD particles	1204:1224	Compared with native β-CD particles, these hybrid particles had higher ζ-potential absolute values, and the SBP could also increase the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs.
33838198	4	53	theme	%	670:670	arg1	φ					662:662	φ	662:662	φ	662:662	The results indicated that the mixture could induce the formation of HIPEs with an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature.
33838198	4	53	theme	%	670:670	arg1	fraction					652:659	an oil phase volume fraction	632:659	an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature	632:735	The results indicated that the mixture could induce the formation of HIPEs with an oil phase volume fraction (φ) of 75% using a one-step high-speed shearing process at room temperature.
33838198	8	54	theme	aqueous	1343:1349	arg1	phase					1351:1355	the aqueous phase	1339:1355	the aqueous phase	1339:1355	Compared with native β-CD particles, these hybrid particles had higher ζ-potential absolute values, and the SBP could also increase the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs.
33838198	5	55	contain	had	829:831	arg1	concentration					796:808	concentration	796:808	concentration (W)	796:812	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	5	55	contain	had	829:831	arg1	composition					742:752	The composition	738:752	The composition (the mass ratio of β-CD to SBP, Rc/s)	738:790	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	5	55	contain	had	829:831	arg2	effects					845:851	significant effects	833:851	significant effects	833:851	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	5	55	contain	had	829:831	arg1	ratio					764:768	the mass ratio	755:768	the mass ratio of β-CD to SBP	755:783	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	5	55	contain	had	829:831	arg1	W					811:811	W	811:811	W	811:811	The composition (the mass ratio of β-CD to SBP, Rc/s) and concentration (W) of the mixture had significant effects on the formation and properties of HIPEs.
33838198	3	56	theme	hybrid	462:467	arg1	particles					469:477	The corresponding hybrid particles	444:477	The corresponding hybrid particles	444:477	The corresponding hybrid particles were also separated and characterized to reveal the formation mechanism.
33838198	6	57	theme	lutein	1024:1029	arg1	effects					1042:1048	lutein protection effects	1024:1048	lutein protection effects	1024:1048	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	8	58	theme	native	1204:1209	arg1	particles					1216:1224	native β-CD particles	1204:1224	native β-CD particles	1204:1224	Compared with native β-CD particles, these hybrid particles had higher ζ-potential absolute values, and the SBP could also increase the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs.
33838198	1	59	theme	Food-grade	133:142	arg1	HIPEs					185:189	Food-grade Pickering high internal phase emulsions (HIPEs)	133:190	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP)	133:267	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP) were fabricated for the first time.
33838198	1	60	theme	β-cyclodextrin	219:232	arg1	mixture					208:214	a mixture	206:214	a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP)	206:267	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP) were fabricated for the first time.
33838198	6	61	theme	gel	971:973	arg1	strengths					975:983	higher gel strengths	964:983	higher gel strengths	964:983	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	8	62	theme	absolute	1273:1280	arg1	values					1282:1287	higher ζ-potential absolute values	1254:1287	higher ζ-potential absolute values	1254:1287	Compared with native β-CD particles, these hybrid particles had higher ζ-potential absolute values, and the SBP could also increase the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs.
33838198	8	63	theme	ζ-potential	1261:1271	arg1	values					1282:1287	higher ζ-potential absolute values	1254:1287	higher ζ-potential absolute values	1254:1287	Compared with native β-CD particles, these hybrid particles had higher ζ-potential absolute values, and the SBP could also increase the viscosity of the aqueous phase, which contributed to the formation and properties of these HIPEs.
33838198	1	64	theme	Pickering	144:152	arg1	HIPEs					185:189	Food-grade Pickering high internal phase emulsions (HIPEs)	133:190	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP)	133:267	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP) were fabricated for the first time.
33838198	6	65	theme	oil	950:952	arg1	droplets					954:961	smaller oil droplets	942:961	smaller oil droplets	942:961	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	6	66	theme	≥	902:902	arg1	%					907:907	W ≥ 1.0%	900:907	W ≥ 1.0%	900:907	When W ≥ 1.0% and Rc/s = 2:2 or 3:1, HIPEs had smaller oil droplets, higher gel strengths, better centrifugation stabilities and lutein protection effects.
33838198	1	67	theme	first	293:297	arg1	time					299:302	the first time	289:302	the first time	289:302	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP) were fabricated for the first time.
33838198	2	68	theme	Pickering	394:402	arg1	HIPEs					404:408	the Pickering HIPEs	390:408	the Pickering HIPEs	390:408	The factors affecting the microstructures, mechanical properties, and stabilities of the Pickering HIPEs were systematically investigated.
33838198	1	69	theme	high	154:157	arg1	HIPEs					185:189	Food-grade Pickering high internal phase emulsions (HIPEs)	133:190	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP)	133:267	Food-grade Pickering high internal phase emulsions (HIPEs) stabilized by a mixture of β-cyclodextrin (β-CD) and sugar beet pectin (SBP) were fabricated for the first time.
33243559	0	0	theme	heating	77:83	arg1	temperatures					85:96	high heating temperatures	72:96	high heating temperatures using Rapid Visco Analyzer 4800	72:128	Evaluation of pasting and gelling properties of commercial flours under high heating temperatures using Rapid Visco Analyzer 4800.
33243559	4	1	theme	Chemical	955:962	arg1	compositions					964:975	140 °C. Chemical compositions	947:975	140 °C. Chemical compositions	947:975	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	0	2	theme	high	72:75	arg1	temperatures					85:96	high heating temperatures	72:96	high heating temperatures using Rapid Visco Analyzer 4800	72:128	Evaluation of pasting and gelling properties of commercial flours under high heating temperatures using Rapid Visco Analyzer 4800.
33243559	1	3	theme	starch	333:338	arg1	p < 0.01					350:357	p < 0.01	350:357	p < 0.01	350:357	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	1	3	theme	starch	333:338	arg1	contents					340:347	starch contents	333:347	starch contents (p < 0.01)	333:358	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	4	4	theme	hard	840:843	arg1	gels					845:848	hard gels	840:848	hard gels	840:848	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	1	5	theme	fiber	413:417	arg1	contents					419:426	fiber contents	413:426	fiber contents	413:426	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	1	6	theme	pasting	146:152	arg1	behaviors					166:174	pasting and gelling behaviors	146:174	pasting and gelling behaviors of flours	146:184	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	4	7	theme	flours	1032:1037	arg1	compositions					964:975	140 °C. Chemical compositions	947:975	140 °C. Chemical compositions	947:975	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	4	7	theme	flours	1032:1037	arg1	sizes					987:991	particle sizes	978:991	particle sizes	978:991	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	4	7	theme	flours	1032:1037	arg1	properties					1006:1015	thermal properties	998:1015	thermal properties	998:1015	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	4	8	theme	gelling	1068:1074	arg1	properties					1076:1085	their pasting and gelling properties	1050:1085	their pasting and gelling properties	1050:1085	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	4	9	theme	firmest	918:924	arg1	gel					926:928	the firmest gel	914:928	the firmest gel	914:928	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	1	10	theme	protein	390:396	arg1	p < 0.01					399:406	protein (p < 0.01)	390:407	protein (p < 0.01)	390:407	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	1	10	theme	protein	390:396	arg1	p < 0.05					429:436	p < 0.05	429:436	p < 0.05	429:436	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	4	11	theme	studied	1024:1030	arg1	flours					1032:1037	the studied flours	1020:1037	the studied flours	1020:1037	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	4	12	theme	140 °C.	947:953	arg1	compositions					964:975	140 °C. Chemical compositions	947:975	140 °C. Chemical compositions	947:975	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	2	13	theme	pasting	493:499	arg1	temperatures					501:512	pasting temperatures	493:512	pasting temperatures	493:512	When the heating temperature increased, pasting temperatures and peak viscosities of most waxy and normal flours largely remained the same, but their holding strengths and final viscosities gradually decreased.
33243559	2	14	theme	flours	559:564	arg1	viscosities					523:533	peak viscosities	518:533	peak viscosities	518:533	When the heating temperature increased, pasting temperatures and peak viscosities of most waxy and normal flours largely remained the same, but their holding strengths and final viscosities gradually decreased.
33243559	2	14	theme	flours	559:564	arg1	temperatures					501:512	pasting temperatures	493:512	pasting temperatures	493:512	When the heating temperature increased, pasting temperatures and peak viscosities of most waxy and normal flours largely remained the same, but their holding strengths and final viscosities gradually decreased.
33243559	1	15	theme	peak	256:259	arg1	viscosities					275:285	both peak and breakdown viscosities	251:285	viscosities	275:285	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	0	16	theme	Visco	110:114	arg1	Analyzer					116:123	Rapid Visco Analyzer 4800	104:128	Rapid Visco Analyzer 4800	104:128	Evaluation of pasting and gelling properties of commercial flours under high heating temperatures using Rapid Visco Analyzer 4800.
33243559	4	17	theme	pulse	820:824	arg1	flours					826:831	Normal maize and pulse flours	803:831	flours	826:831	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	2	18	theme	holding	603:609	arg1	strengths					611:619	their holding strengths	597:619	their holding strengths	597:619	When the heating temperature increased, pasting temperatures and peak viscosities of most waxy and normal flours largely remained the same, but their holding strengths and final viscosities gradually decreased.
33243559	0	19	theme	Rapid	104:108	arg1	Analyzer					116:123	Rapid Visco Analyzer 4800	104:128	Rapid Visco Analyzer 4800	104:128	Evaluation of pasting and gelling properties of commercial flours under high heating temperatures using Rapid Visco Analyzer 4800.
33243559	3	20	theme	high-amylose	683:694	arg1	flours					702:707	high-amylose maize flours	683:707	high-amylose maize flours	683:707	However, pulse and high-amylose maize flours required a holding temperature above 95 °C to achieve the highest peak and final viscosities.
33243559	4	21	theme	different	1115:1123	arg1	temperatures					1133:1144	the different heating temperatures	1111:1144	the different heating temperatures	1111:1144	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	1	22	theme	gelling	158:164	arg1	behaviors					166:174	pasting and gelling behaviors	146:174	pasting and gelling behaviors of flours	146:184	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	3	23	theme	maize	696:700	arg1	flours					702:707	high-amylose maize flours	683:707	high-amylose maize flours	683:707	However, pulse and high-amylose maize flours required a holding temperature above 95 °C to achieve the highest peak and final viscosities.
33243559	1	24	theme	breakdown	265:273	arg1	viscosities					275:285	both peak and breakdown viscosities	251:285	viscosities	275:285	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	4	25	theme	maize	892:896	arg1	flour					898:902	high-amylose maize flour	879:902	high-amylose maize flour	879:902	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	2	26	theme	final	625:629	arg1	viscosities					631:641	final viscosities	625:641	final viscosities	625:641	When the heating temperature increased, pasting temperatures and peak viscosities of most waxy and normal flours largely remained the same, but their holding strengths and final viscosities gradually decreased.
33243559	1	27	theme	flours	179:184	arg1	behaviors					166:174	pasting and gelling behaviors	146:174	pasting and gelling behaviors of flours	146:184	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	0	28	theme	pasting	14:20	arg1	properties					34:43	pasting and gelling properties	14:43	pasting and gelling properties of commercial flours under high heating temperatures using Rapid Visco Analyzer 4800	14:128	Evaluation of pasting and gelling properties of commercial flours under high heating temperatures using Rapid Visco Analyzer 4800.
33243559	4	29	theme	high-amylose	879:890	arg1	flour					898:902	high-amylose maize flour	879:902	high-amylose maize flour	879:902	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	4	30	theme	certain	1090:1096	arg1	levels					1098:1103	certain levels	1090:1103	certain levels under the different heating temperatures	1090:1144	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	0	31	theme	properties	34:43	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of pasting and gelling properties of commercial flours under high heating temperatures using Rapid Visco Analyzer 4800.	0:129	Evaluation of pasting and gelling properties of commercial flours under high heating temperatures using Rapid Visco Analyzer 4800.
33243559	3	32	theme	holding	720:726	arg1	temperature					728:738	a holding temperature	718:738	a holding temperature above 95 °C	718:750	However, pulse and high-amylose maize flours required a holding temperature above 95 °C to achieve the highest peak and final viscosities.
33243559	2	33	theme	peak	518:521	arg1	viscosities					523:533	peak viscosities	518:533	peak viscosities	518:533	When the heating temperature increased, pasting temperatures and peak viscosities of most waxy and normal flours largely remained the same, but their holding strengths and final viscosities gradually decreased.
33243559	0	34	theme	gelling	26:32	arg1	properties					34:43	pasting and gelling properties	14:43	pasting and gelling properties of commercial flours under high heating temperatures using Rapid Visco Analyzer 4800	14:128	Evaluation of pasting and gelling properties of commercial flours under high heating temperatures using Rapid Visco Analyzer 4800.
33243559	0	35	theme	commercial	48:57	arg1	flours					59:64	commercial flours	48:64	commercial flours under high heating temperatures using Rapid Visco Analyzer 4800	48:128	Evaluation of pasting and gelling properties of commercial flours under high heating temperatures using Rapid Visco Analyzer 4800.
33243559	1	36	theme	flours	294:299	arg1	viscosities					275:285	both peak and breakdown viscosities	251:285	viscosities	275:285	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	2	37	theme	normal	552:557	arg1	flours					559:564	most waxy and normal flours	538:564	flours	559:564	When the heating temperature increased, pasting temperatures and peak viscosities of most waxy and normal flours largely remained the same, but their holding strengths and final viscosities gradually decreased.
33243559	1	38	dep	temperatures	215:226	arg1	correlated					317:326	correlated	317:326	positively correlated with starch contents (p < 0.01)	306:358	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	1	38	dep	temperatures	215:226	arg1	correlated					374:383	correlated	374:383	inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C	364:450	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	1	39	from	95-140 °C	442:450	arg1	p < 0.01					399:406	protein (p < 0.01)	390:407	protein (p < 0.01)	390:407	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	1	39	from	95-140 °C	442:450	arg1	p < 0.05					429:436	p < 0.05	429:436	p < 0.05	429:436	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	1	39	from	95-140 °C	442:450	arg1	contents					419:426	fiber contents	413:426	fiber contents	413:426	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	4	40	theme	particle	978:985	arg1	sizes					987:991	particle sizes	978:991	particle sizes	978:991	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	4	41	theme	Normal	803:808	arg1	maize					810:814	Normal maize and pulse flours	803:831	maize	810:814	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	2	42	theme	waxy	543:546	arg1	viscosities					523:533	peak viscosities	518:533	peak viscosities	518:533	When the heating temperature increased, pasting temperatures and peak viscosities of most waxy and normal flours largely remained the same, but their holding strengths and final viscosities gradually decreased.
33243559	2	42	theme	waxy	543:546	arg1	temperatures					501:512	pasting temperatures	493:512	pasting temperatures	493:512	When the heating temperature increased, pasting temperatures and peak viscosities of most waxy and normal flours largely remained the same, but their holding strengths and final viscosities gradually decreased.
33243559	1	43	theme	heating	207:213	arg1	temperatures					215:226	heating temperatures	207:226	heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C	207:450	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
33243559	2	44	theme	most	538:541	arg1	waxy					543:546	most waxy and normal flours	538:564	waxy	543:546	When the heating temperature increased, pasting temperatures and peak viscosities of most waxy and normal flours largely remained the same, but their holding strengths and final viscosities gradually decreased.
33243559	2	45	theme	heating	462:468	arg1	temperature					470:480	the heating temperature	458:480	the heating temperature	458:480	When the heating temperature increased, pasting temperatures and peak viscosities of most waxy and normal flours largely remained the same, but their holding strengths and final viscosities gradually decreased.
33243559	3	46	theme	final	784:788	arg1	viscosities					790:800	final viscosities	784:800	final viscosities	784:800	However, pulse and high-amylose maize flours required a holding temperature above 95 °C to achieve the highest peak and final viscosities.
33243559	4	47	theme	heating	1125:1131	arg1	temperatures					1133:1144	the different heating temperatures	1111:1144	the different heating temperatures	1111:1144	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	4	48	theme	pasting	1056:1062	arg1	properties					1076:1085	their pasting and gelling properties	1050:1085	their pasting and gelling properties	1050:1085	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	3	49	theme	highest	767:773	arg1	peak					775:778	peak	775:778	peak	775:778	However, pulse and high-amylose maize flours required a holding temperature above 95 °C to achieve the highest peak and final viscosities.
33243559	0	50	theme	flours	59:64	arg1	properties					34:43	pasting and gelling properties	14:43	pasting and gelling properties of commercial flours under high heating temperatures using Rapid Visco Analyzer 4800	14:128	Evaluation of pasting and gelling properties of commercial flours under high heating temperatures using Rapid Visco Analyzer 4800.
33243559	4	51	theme	thermal	998:1004	arg1	properties					1006:1015	thermal properties	998:1015	thermal properties	998:1015	Normal maize and pulse flours formed hard gels after cooking at 120 °C, and high-amylose maize flour developed the firmest gel after cooking at 140 °C. Chemical compositions, particle sizes, and thermal properties of the studied flours influenced their pasting and gelling properties to certain levels under the different heating temperatures.
33243559	1	52	theme	95-140 °C.	231:240	arg1	temperatures					215:226	heating temperatures	207:226	heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C	207:450	In this study, pasting and gelling behaviors of flours were investigated at heating temperatures of 95-140 °C. Overall, both peak and breakdown viscosities of the flours were positively correlated with starch contents (p < 0.01) but inversely correlated with protein (p < 0.01) and fiber contents (p < 0.05) at 95-140 °C.
32510089	6	0	dep	in	964:965	arg1	vivo					967:970	vivo	967:970	vivo	967:970	The in vivo tests demonstrate much lower inflammatory response to the BC/CA graft.
32510089	3	1	theme	porous	573:578	arg1	structure					580:588	well-interconnected porous structure	553:588	well-interconnected porous structure	553:588	Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts.
32510089	4	2	theme	BC/CA	632:636	arg1	graft					638:642	the BC/CA graft	628:642	the BC/CA graft with a suitable BC content	628:669	It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts.
32510089	7	3	theme	cell	1171:1174	arg1	monolayer					1176:1184	an endothelial cell monolayer	1156:1184	an endothelial cell monolayer	1156:1184	These results suggest that the BC/CA graft shows a great potential as an artificial graft for rapid formation of an endothelial cell monolayer.
32510089	5	4	theme	Western	797:803	arg1	blotting					805:812	Western blotting	797:812	Western blotting	797:812	Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31.
32510089	7	5	theme	monolayer	1176:1184	arg1	formation					1143:1151	rapid formation	1137:1151	rapid formation of an endothelial cell monolayer	1137:1184	These results suggest that the BC/CA graft shows a great potential as an artificial graft for rapid formation of an endothelial cell monolayer.
32510089	3	6	dep	morphology	538:547	arg1	the					512:514	the	512:514	the	512:514	Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts.
32510089	4	7	theme	CA	780:781	arg1	counterparts					783:794	the BC and CA counterparts	769:794	the BC and CA counterparts	769:794	It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts.
32510089	5	8	theme	blotting	805:812	arg1	results					826:832	Western blotting and RT-qPCR results	797:832	Western blotting and RT-qPCR results	797:832	Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31.
32510089	6	9	theme	in	964:965	arg1	tests					972:976	The in vivo tests	960:976	The in vivo tests	960:976	The in vivo tests demonstrate much lower inflammatory response to the BC/CA graft.
32510089	5	10	theme	genes	921:925	arg1	CD31					954:957	protein CD31	946:957	protein CD31	946:957	Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31.
32510089	5	10	theme	genes	921:925	arg1	expressions					906:916	expressions	906:916	expressions of genes vWF-1 and CD31	906:940	Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31.
32510089	3	11	theme	BC/CA	597:601	arg1	grafts					603:608	the BC/CA grafts	593:608	the BC/CA grafts	593:608	Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts.
32510089	3	12	theme	electron	468:475	arg1	SEM					489:491	SEM	489:491	SEM	489:491	Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts.
32510089	3	12	theme	electron	468:475	arg1	microscopy					477:486	Scanning electron microscopy	459:486	Scanning electron microscopy (SEM) observation	459:504	Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts.
32510089	2	13	theme	in	437:438	arg1	biosynthesis					445:456	step-by-step in situ biosynthesis	424:456	step-by-step in situ biosynthesis	424:456	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	7	14	theme	endothelial	1159:1169	arg1	monolayer					1176:1184	an endothelial cell monolayer	1156:1184	an endothelial cell monolayer	1156:1184	These results suggest that the BC/CA graft shows a great potential as an artificial graft for rapid formation of an endothelial cell monolayer.
32510089	3	15	theme	grafts	603:608	arg1	structure					580:588	well-interconnected porous structure	553:588	well-interconnected porous structure	553:588	Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts.
32510089	3	15	theme	grafts	603:608	arg1	morphology					538:547	nano/submicro-fibrous morphology	516:547	nano/submicro-fibrous morphology	516:547	Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts.
32510089	2	16	theme	step-by-step	424:435	arg1	biosynthesis					445:456	step-by-step in situ biosynthesis	424:456	step-by-step in situ biosynthesis	424:456	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	6	17	theme	BC/CA	1030:1034	arg1	graft					1036:1040	the BC/CA graft	1026:1040	the BC/CA graft	1026:1040	The in vivo tests demonstrate much lower inflammatory response to the BC/CA graft.
32510089	5	18	theme	RT-qPCR	818:824	arg1	results					826:832	Western blotting and RT-qPCR results	797:832	Western blotting and RT-qPCR results	797:832	Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31.
32510089	5	19	theme	protein	946:952	arg1	CD31					954:957	protein CD31	946:957	protein CD31	946:957	Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31.
32510089	1	20	theme	vascular	208:215	arg1	grafts					217:222	vascular grafts	208:222	vascular grafts	208:222	Mimicking the morphological structure of native blood vessels is critical for the development of vascular grafts.
32510089	0	21	theme	Controllable	0:11	arg1	synthesis					13:21	Controllable synthesis	0:21	Controllable synthesis of biomimetic nano/submicro-fibrous	0:57	Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts.
32510089	2	22	theme	cellulose	350:358	arg1	CA					369:370	CA	369:370	CA	369:370	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	2	22	theme	cellulose	350:358	arg1	acetate					360:366	submicrofibrous cellulose acetate	334:366	submicrofibrous cellulose acetate (CA)	334:371	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	1	23	theme	grafts	217:222	arg1	development					193:203	the development	189:203	the development of vascular grafts	189:222	Mimicking the morphological structure of native blood vessels is critical for the development of vascular grafts.
32510089	0	24	theme	biomimetic	26:35	arg1	nano/submicro-fibrous					37:57	biomimetic nano/submicro-fibrous	26:57	biomimetic nano/submicro-fibrous	26:57	Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts.
32510089	4	25	with	graft	638:642	arg1	content					663:669	a suitable BC content	649:669	a suitable BC content	649:669	It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts.
32510089	2	26	theme	submicrofibrous	334:348	arg1	CA					369:370	CA	369:370	CA	369:370	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	2	26	theme	submicrofibrous	334:348	arg1	acetate					360:366	submicrofibrous cellulose acetate	334:366	submicrofibrous cellulose acetate (CA)	334:371	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	7	27	theme	rapid	1137:1141	arg1	formation					1143:1151	rapid formation	1137:1151	rapid formation of an endothelial cell monolayer	1137:1184	These results suggest that the BC/CA graft shows a great potential as an artificial graft for rapid formation of an endothelial cell monolayer.
32510089	4	28	theme	lower	684:688	arg1	potential					690:698	lower potential	684:698	lower potential of thrombus formation and enhanced endothelialization	684:752	It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts.
32510089	3	29	theme	well-interconnected	553:571	arg1	structure					580:588	well-interconnected porous structure	553:588	well-interconnected porous structure	553:588	Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts.
32510089	7	30	theme	artificial	1116:1125	arg1	graft					1127:1131	an artificial graft	1113:1131	an artificial graft for rapid formation of an endothelial cell monolayer	1113:1184	These results suggest that the BC/CA graft shows a great potential as an artificial graft for rapid formation of an endothelial cell monolayer.
32510089	3	31	theme	microscopy	477:486	arg1	observation					494:504	Scanning electron microscopy (SEM) observation	459:504	Scanning electron microscopy (SEM) observation	459:504	Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts.
32510089	4	32	theme	thrombus	703:710	arg1	formation					712:720	thrombus formation	703:720	thrombus formation	703:720	It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts.
32510089	0	33	theme	nano/submicro-fibrous	37:57	arg1	synthesis					13:21	Controllable synthesis	0:21	Controllable synthesis of biomimetic nano/submicro-fibrous	0:57	Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts.
32510089	3	34	theme	Scanning	459:466	arg1	SEM					489:491	SEM	489:491	SEM	489:491	Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts.
32510089	3	34	theme	Scanning	459:466	arg1	microscopy					477:486	Scanning electron microscopy	459:486	Scanning electron microscopy (SEM) observation	459:504	Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts.
32510089	6	35	theme	inflammatory	1001:1012	arg1	response					1014:1021	much lower inflammatory response	990:1021	much lower inflammatory response to the BC/CA graft	990:1040	The in vivo tests demonstrate much lower inflammatory response to the BC/CA graft.
32510089	0	36	theme	potential	69:77	arg1	grafts					103:108	potential small-diameter vascular grafts	69:108	potential small-diameter vascular grafts	69:108	Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts.
32510089	4	37	theme	endothelialization	735:752	arg1	potential					690:698	lower potential	684:698	lower potential of thrombus formation and enhanced endothelialization	684:752	It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts.
32510089	2	38	theme	vascular	258:265	arg1	grafts					267:272	small-diameter composite vascular grafts	233:272	small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA)	233:371	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	4	39	theme	suitable	651:658	arg1	content					663:669	a suitable BC content	649:669	a suitable BC content	649:669	It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts.
32510089	2	40	theme	small-diameter	233:246	arg1	grafts					267:272	small-diameter composite vascular grafts	233:272	small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA)	233:371	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	2	41	theme	composite	248:256	arg1	grafts					267:272	small-diameter composite vascular grafts	233:272	small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA)	233:371	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	7	42	theme	BC/CA	1074:1078	arg1	graft					1080:1084	the BC/CA graft	1070:1084	the BC/CA graft	1070:1084	These results suggest that the BC/CA graft shows a great potential as an artificial graft for rapid formation of an endothelial cell monolayer.
32510089	1	43	theme	native	152:157	arg1	vessels					165:171	native blood vessels	152:171	native blood vessels	152:171	Mimicking the morphological structure of native blood vessels is critical for the development of vascular grafts.
32510089	5	44	dep	genes	921:925	arg1	vWF-1					927:931	vWF-1	927:931	vWF-1	927:931	Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31.
32510089	5	44	dep	genes	921:925	arg1	genes					921:925	genes vWF-1 and CD31	921:940	genes vWF-1 and CD31	921:940	Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31.
32510089	5	44	dep	genes	921:925	arg1	CD31					937:940	CD31	937:940	CD31	937:940	Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31.
32510089	7	45	theme	great	1094:1098	arg1	potential					1100:1108	a great potential	1092:1108	a great potential as an artificial graft for rapid formation of an endothelial cell monolayer	1092:1184	These results suggest that the BC/CA graft shows a great potential as an artificial graft for rapid formation of an endothelial cell monolayer.
32510089	4	46	theme	enhanced	726:733	arg1	endothelialization					735:752	enhanced endothelialization	726:752	enhanced endothelialization	726:752	It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts.
32510089	2	47	theme	bacterial	305:313	arg1	BC					326:327	BC	326:327	BC	326:327	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	2	47	theme	bacterial	305:313	arg1	cellulose					315:323	the nanofibrous bacterial cellulose	289:323	the nanofibrous bacterial cellulose (BC)	289:328	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	1	48	theme	blood	159:163	arg1	vessels					165:171	native blood vessels	152:171	native blood vessels	152:171	Mimicking the morphological structure of native blood vessels is critical for the development of vascular grafts.
32510089	1	49	theme	morphological	125:137	arg1	structure					139:147	the morphological structure	121:147	the morphological structure of native blood vessels	121:171	Mimicking the morphological structure of native blood vessels is critical for the development of vascular grafts.
32510089	4	50	theme	BC	660:661	arg1	content					663:669	a suitable BC content	649:669	a suitable BC content	649:669	It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts.
32510089	2	51	theme	nanofibrous	293:303	arg1	BC					326:327	BC	326:327	BC	326:327	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	2	51	theme	nanofibrous	293:303	arg1	cellulose					315:323	the nanofibrous bacterial cellulose	289:323	the nanofibrous bacterial cellulose (BC)	289:328	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	1	52	theme	vessels	165:171	arg1	structure					139:147	the morphological structure	121:147	the morphological structure of native blood vessels	121:171	Mimicking the morphological structure of native blood vessels is critical for the development of vascular grafts.
32510089	3	53	theme	nano/submicro-fibrous	516:536	arg1	morphology					538:547	nano/submicro-fibrous morphology	516:547	nano/submicro-fibrous morphology	516:547	Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts.
32510089	0	54	theme	vascular	94:101	arg1	grafts					103:108	potential small-diameter vascular grafts	69:108	potential small-diameter vascular grafts	69:108	Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts.
32510089	2	55	dep	in	437:438	arg1	situ					440:443	situ	440:443	situ	440:443	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	2	56	theme	combined	395:402	arg1	electrospinning					404:418	a combined electrospinning	393:418	a combined electrospinning	393:418	Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricated via a combined electrospinning and step-by-step in situ biosynthesis.
32510089	4	57	theme	formation	712:720	arg1	potential					690:698	lower potential	684:698	lower potential of thrombus formation and enhanced endothelialization	684:752	It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts.
32510089	0	58	theme	small-diameter	79:92	arg1	grafts					103:108	potential small-diameter vascular grafts	69:108	potential small-diameter vascular grafts	69:108	Controllable synthesis of biomimetic nano/submicro-fibrous tubes for potential small-diameter vascular grafts.
32510089	6	59	theme	lower	995:999	arg1	response					1014:1021	much lower inflammatory response	990:1021	much lower inflammatory response to the BC/CA graft	990:1040	The in vivo tests demonstrate much lower inflammatory response to the BC/CA graft.
32510089	5	60	theme	BC/CA-2	851:857	arg1	graft					859:863	the BC/CA-2 graft	847:863	the BC/CA-2 graft	847:863	Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31.
32510089	4	61	theme	BC	773:774	arg1	counterparts					783:794	the BC and CA counterparts	769:794	the BC and CA counterparts	769:794	It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts.
33522128	0	0	theme	Chemical	123:130	arg1	bacterium					212:220	the predominant Gram-negative bacterium	182:220	the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches	182:280	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	0	theme	Chemical	123:130	arg1	Determination					105:117	Complete Structure Determination	86:117	Complete Structure Determination	86:117	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	0	theme	Chemical	123:130	arg1	Synthesis					132:140	Chemical Synthesis	123:140	Chemical Synthesis	123:140	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	1	1	theme	receptor 4	389:398	arg1	receptor					447:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor	379:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation	379:520	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	0	2	theme	lymphoid	248:255	arg1	tissues					257:263	gut-associated lymphoid tissues	233:263	gut-associated lymphoid tissues	233:263	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	2	theme	lymphoid	248:255	arg1	patches					274:280	Peyer's patches	266:280	Peyer's patches	266:280	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	2	3	from	A. faecalis	691:701	arg1	LOS					673:675	LOS	673:675	LOS	673:675	In this study, we characterized the structure of both the lipooligosaccharide (LOS) and LPS from A. faecalis.
33522128	2	3	from	A. faecalis	691:701	arg1	LPS					682:684	LPS	682:684	LPS from A. faecalis	682:701	In this study, we characterized the structure of both the lipooligosaccharide (LOS) and LPS from A. faecalis.
33522128	2	3	from	A. faecalis	691:701	arg1	lipooligosaccharide					652:670	the lipooligosaccharide	648:670	the lipooligosaccharide (LOS)	648:676	In this study, we characterized the structure of both the lipooligosaccharide (LOS) and LPS from A. faecalis.
33522128	2	3	from	A. faecalis	691:701	arg1	structure					630:638	the structure	626:638	the structure of both the lipooligosaccharide (LOS) and LPS from A. faecalis	626:701	In this study, we characterized the structure of both the lipooligosaccharide (LOS) and LPS from A. faecalis.
33522128	3	4	theme	4'-phosphates	851:863	arg1	introduction					828:839	the simultaneous introduction	811:839	the simultaneous introduction of 1- and 4'-phosphates	811:863	We synthesized three lipid A molecules with different degrees of acylation by an efficient route involving the simultaneous introduction of 1- and 4'-phosphates.
33522128	0	5	theme	gut-associated	233:246	arg1	tissues					257:263	gut-associated lymphoid tissues	233:263	gut-associated lymphoid tissues	233:263	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	5	theme	gut-associated	233:246	arg1	patches					274:280	Peyer's patches	266:280	Peyer's patches	266:280	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	1	6	theme	potent	469:474	arg1	inducer					476:482	a potent inducer	467:482	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation	379:520	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	1	7	theme	A. faecalis	314:324	arg1	agonist					367:373	a weak agonist	360:373	a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation	360:520	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	1	7	theme	A. faecalis	314:324	arg1	LPS					346:348	LPS	346:348	LPS	346:348	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	1	7	theme	A. faecalis	314:324	arg1	lipopolysaccharide					326:343	an A. faecalis lipopolysaccharide	311:343	an A. faecalis lipopolysaccharide (LPS)	311:349	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	4	8	theme	interleukin-6	1003:1015	arg1	release					1017:1023	a discrete interleukin-6 release	992:1023	a discrete interleukin-6 release	992:1023	Hexaacylated A. faecalis lipid A showed moderate agonistic activity towards TLR4-mediated signaling and the ability to elicit a discrete interleukin-6 release in human cell lines and mice.
33522128	1	9	theme	TLR4	401:404	arg1	receptor					447:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor	379:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation	379:520	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	3	10	theme	1-	844:845	arg1	introduction					828:839	the simultaneous introduction	811:839	the simultaneous introduction of 1- and 4'-phosphates	811:863	We synthesized three lipid A molecules with different degrees of acylation by an efficient route involving the simultaneous introduction of 1- and 4'-phosphates.
33522128	4	11	theme	discrete	994:1001	arg1	release					1017:1023	a discrete interleukin-6 release	992:1023	a discrete interleukin-6 release	992:1023	Hexaacylated A. faecalis lipid A showed moderate agonistic activity towards TLR4-mediated signaling and the ability to elicit a discrete interleukin-6 release in human cell lines and mice.
33522128	5	12	theme	promising	1121:1129	arg1	candidate					1148:1156	a promising vaccine adjuvant candidate	1119:1156	a promising vaccine adjuvant candidate	1119:1156	It was thus found to be the active principle of the LOS/LPS and a promising vaccine adjuvant candidate.
33522128	1	13	used	used	569:572	arg2	adjuvant					584:591	adjuvant	584:591	adjuvant	584:591	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	1	13	used	used	569:572	arg2	LPS					556:558	A. faecalis LPS	544:558	A. faecalis LPS	544:558	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	0	14	theme	Lipid A.	149:156	arg1	faecalis					170:177	Its Lipid A. Alcaligenes faecalis	145:177	Its Lipid A. Alcaligenes faecalis	145:177	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	1	15	theme	/myeloid	406:413	arg1	receptor					447:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor	379:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation	379:520	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	4	16	theme	A. faecalis	879:889	arg1	lipid A					891:897	Hexaacylated A. faecalis lipid A	866:897	Hexaacylated A. faecalis lipid A	866:897	Hexaacylated A. faecalis lipid A showed moderate agonistic activity towards TLR4-mediated signaling and the ability to elicit a discrete interleukin-6 release in human cell lines and mice.
33522128	1	17	theme	IgA	487:489	arg1	receptor					447:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor	379:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation	379:520	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	1	17	theme	IgA	487:489	arg1	inducer					476:482	a potent inducer	467:482	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation	379:520	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	4	18	theme	agonistic	915:923	arg1	activity					925:932	moderate agonistic activity	906:932	moderate agonistic activity towards TLR4-mediated signaling	906:964	Hexaacylated A. faecalis lipid A showed moderate agonistic activity towards TLR4-mediated signaling and the ability to elicit a discrete interleukin-6 release in human cell lines and mice.
33522128	0	19	from	faecalis	76:83	arg1	Lipopolysaccharide					0:17	Lipopolysaccharide	0:17	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.	0:281	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	4	20	theme	Hexaacylated	866:877	arg1	lipid A					891:897	Hexaacylated A. faecalis lipid A	866:897	Hexaacylated A. faecalis lipid A	866:897	Hexaacylated A. faecalis lipid A showed moderate agonistic activity towards TLR4-mediated signaling and the ability to elicit a discrete interleukin-6 release in human cell lines and mice.
33522128	5	21	theme	vaccine	1131:1137	arg1	candidate					1148:1156	a promising vaccine adjuvant candidate	1119:1156	a promising vaccine adjuvant candidate	1119:1156	It was thus found to be the active principle of the LOS/LPS and a promising vaccine adjuvant candidate.
33522128	3	22	theme	lipid A	725:731	arg1	molecules					733:741	three lipid A molecules	719:741	three lipid A molecules	719:741	We synthesized three lipid A molecules with different degrees of acylation by an efficient route involving the simultaneous introduction of 1- and 4'-phosphates.
33522128	1	23	theme	factor-2	431:438	arg1	receptor					447:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor	379:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation	379:520	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	1	24	theme	excessive	499:507	arg1	inflammation					509:520	excessive inflammation	499:520	excessive inflammation	499:520	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	3	25	theme	different	748:756	arg1	degrees					758:764	different degrees	748:764	different degrees of acylation	748:777	We synthesized three lipid A molecules with different degrees of acylation by an efficient route involving the simultaneous introduction of 1- and 4'-phosphates.
33522128	3	26	theme	acylation	769:777	arg1	degrees					758:764	different degrees	748:764	different degrees of acylation	748:777	We synthesized three lipid A molecules with different degrees of acylation by an efficient route involving the simultaneous introduction of 1- and 4'-phosphates.
33522128	2	27	theme	LPS	682:684	arg1	structure					630:638	the structure	626:638	the structure of both the lipooligosaccharide (LOS) and LPS from A. faecalis	626:701	In this study, we characterized the structure of both the lipooligosaccharide (LOS) and LPS from A. faecalis.
33522128	4	28	theme	moderate	906:913	arg1	activity					925:932	moderate agonistic activity	906:932	moderate agonistic activity towards TLR4-mediated signaling	906:964	Hexaacylated A. faecalis lipid A showed moderate agonistic activity towards TLR4-mediated signaling and the ability to elicit a discrete interleukin-6 release in human cell lines and mice.
33522128	0	29	theme	Lymphoid-Tissue-Resident	39:62	arg1	faecalis					76:83	Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis	24:83	Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis	24:83	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	30	theme	faecalis	170:177	arg1	bacterium					212:220	the predominant Gram-negative bacterium	182:220	the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches	182:280	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	30	theme	faecalis	170:177	arg1	Determination					105:117	Complete Structure Determination	86:117	Complete Structure Determination	86:117	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	30	theme	faecalis	170:177	arg1	Synthesis					132:140	Chemical Synthesis	123:140	Chemical Synthesis	123:140	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	2	31	theme	lipooligosaccharide	652:670	arg1	structure					630:638	the structure	626:638	the structure of both the lipooligosaccharide (LOS) and LPS from A. faecalis	626:701	In this study, we characterized the structure of both the lipooligosaccharide (LOS) and LPS from A. faecalis.
33522128	0	32	theme	Gut-Associated	24:37	arg1	faecalis					76:83	Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis	24:83	Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis	24:83	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	33	theme	Alcaligenes	158:168	arg1	faecalis					170:177	Its Lipid A. Alcaligenes faecalis	145:177	Its Lipid A. Alcaligenes faecalis	145:177	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	5	34	theme	adjuvant	1139:1146	arg1	candidate					1148:1156	a promising vaccine adjuvant candidate	1119:1156	a promising vaccine adjuvant candidate	1119:1156	It was thus found to be the active principle of the LOS/LPS and a promising vaccine adjuvant candidate.
33522128	1	35	theme	MD-2	441:444	arg1	receptor					447:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor	379:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation	379:520	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	0	36	theme	Alcaligenes	64:74	arg1	faecalis					76:83	Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis	24:83	Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis	24:83	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	3	37	theme	simultaneous	815:826	arg1	introduction					828:839	the simultaneous introduction	811:839	the simultaneous introduction of 1- and 4'-phosphates	811:863	We synthesized three lipid A molecules with different degrees of acylation by an efficient route involving the simultaneous introduction of 1- and 4'-phosphates.
33522128	0	38	theme	Complete	86:93	arg1	bacterium					212:220	the predominant Gram-negative bacterium	182:220	the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches	182:280	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	38	theme	Complete	86:93	arg1	Determination					105:117	Complete Structure Determination	86:117	Complete Structure Determination	86:117	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	38	theme	Complete	86:93	arg1	Synthesis					132:140	Chemical Synthesis	123:140	Chemical Synthesis	123:140	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	1	39	theme	weak	362:365	arg1	lipopolysaccharide					326:343	an A. faecalis lipopolysaccharide	311:343	an A. faecalis lipopolysaccharide (LPS)	311:349	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	1	39	theme	weak	362:365	arg1	agonist					367:373	a weak agonist	360:373	a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation	360:520	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	0	40	theme	Gram-negative	198:210	arg1	bacterium					212:220	the predominant Gram-negative bacterium	182:220	the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches	182:280	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	40	theme	Gram-negative	198:210	arg1	Determination					105:117	Complete Structure Determination	86:117	Complete Structure Determination	86:117	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	40	theme	Gram-negative	198:210	arg1	Synthesis					132:140	Chemical Synthesis	123:140	Chemical Synthesis	123:140	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	4	41	theme	human	1028:1032	arg1	lines					1039:1043	human cell lines	1028:1043	human cell lines	1028:1043	Hexaacylated A. faecalis lipid A showed moderate agonistic activity towards TLR4-mediated signaling and the ability to elicit a discrete interleukin-6 release in human cell lines and mice.
33522128	1	42	theme	differentiation	415:429	arg1	receptor					447:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor	379:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation	379:520	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	0	43	theme	predominant	186:196	arg1	bacterium					212:220	the predominant Gram-negative bacterium	182:220	the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches	182:280	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	43	theme	predominant	186:196	arg1	Determination					105:117	Complete Structure Determination	86:117	Complete Structure Determination	86:117	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	43	theme	predominant	186:196	arg1	Synthesis					132:140	Chemical Synthesis	123:140	Chemical Synthesis	123:140	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	3	44	theme	efficient	785:793	arg1	route					795:799	an efficient route	782:799	an efficient route involving the simultaneous introduction of 1- and 4'-phosphates	782:863	We synthesized three lipid A molecules with different degrees of acylation by an efficient route involving the simultaneous introduction of 1- and 4'-phosphates.
33522128	5	45	theme	active	1083:1088	arg1	principle					1090:1098	the active principle	1079:1098	the active principle of the LOS/LPS	1079:1113	It was thus found to be the active principle of the LOS/LPS and a promising vaccine adjuvant candidate.
33522128	5	45	theme	active	1083:1088	arg1	It					1055:1056	It	1055:1056	It	1055:1056	It was thus found to be the active principle of the LOS/LPS and a promising vaccine adjuvant candidate.
33522128	1	46	theme	A. faecalis	544:554	arg1	adjuvant					584:591	adjuvant	584:591	adjuvant	584:591	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	1	46	theme	A. faecalis	544:554	arg1	LPS					556:558	A. faecalis LPS	544:558	A. faecalis LPS	544:558	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	5	47	theme	LOS/LPS	1107:1113	arg1	principle					1090:1098	the active principle	1079:1098	the active principle of the LOS/LPS	1079:1113	It was thus found to be the active principle of the LOS/LPS and a promising vaccine adjuvant candidate.
33522128	5	47	theme	LOS/LPS	1107:1113	arg1	It					1055:1056	It	1055:1056	It	1055:1056	It was thus found to be the active principle of the LOS/LPS and a promising vaccine adjuvant candidate.
33522128	5	47	theme	LOS/LPS	1107:1113	arg1	candidate					1148:1156	a promising vaccine adjuvant candidate	1119:1156	a promising vaccine adjuvant candidate	1119:1156	It was thus found to be the active principle of the LOS/LPS and a promising vaccine adjuvant candidate.
33522128	4	48	theme	cell	1034:1037	arg1	lines					1039:1043	human cell lines	1028:1043	human cell lines	1028:1043	Hexaacylated A. faecalis lipid A showed moderate agonistic activity towards TLR4-mediated signaling and the ability to elicit a discrete interleukin-6 release in human cell lines and mice.
33522128	4	49	theme	TLR4-mediated	942:954	arg1	signaling					956:964	TLR4-mediated signaling	942:964	TLR4-mediated signaling	942:964	Hexaacylated A. faecalis lipid A showed moderate agonistic activity towards TLR4-mediated signaling and the ability to elicit a discrete interleukin-6 release in human cell lines and mice.
33522128	0	50	theme	Structure	95:103	arg1	bacterium					212:220	the predominant Gram-negative bacterium	182:220	the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches	182:280	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	50	theme	Structure	95:103	arg1	Determination					105:117	Complete Structure Determination	86:117	Complete Structure Determination	86:117	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	50	theme	Structure	95:103	arg1	Synthesis					132:140	Chemical Synthesis	123:140	Chemical Synthesis	123:140	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	1	51	theme	Toll-like	379:387	arg1	receptor					447:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor	379:454	Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation	379:520	We previously reported that an A. faecalis lipopolysaccharide (LPS) acted as a weak agonist for Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2) receptor as well as a potent inducer of IgA without excessive inflammation, thus suggesting that A. faecalis LPS might be used as a safe adjuvant.
33522128	0	52	dep	Lipopolysaccharide	0:17	arg1	bacterium					212:220	the predominant Gram-negative bacterium	182:220	the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches	182:280	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	52	dep	Lipopolysaccharide	0:17	arg1	Determination					105:117	Complete Structure Determination	86:117	Complete Structure Determination	86:117	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	0	52	dep	Lipopolysaccharide	0:17	arg1	Synthesis					132:140	Chemical Synthesis	123:140	Chemical Synthesis	123:140	Lipopolysaccharide from Gut-Associated Lymphoid-Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of Its Lipid A. Alcaligenes faecalis is the predominant Gram-negative bacterium inhabiting gut-associated lymphoid tissues, Peyer's patches.
33522128	2	53	from	structure	630:638	arg1	A. faecalis					691:701	A. faecalis	691:701	A. faecalis	691:701	In this study, we characterized the structure of both the lipooligosaccharide (LOS) and LPS from A. faecalis.
33947577	6	0	theme	multilayer-coated	1008:1024	arg1	samples					1026:1032	Alginate/chitosan multilayer-coated samples	990:1032	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading)	990:1063	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading) showed better direct osteogenic ability than TNTs by promoting biomineralization and up-regulating osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs.
33947577	9	1	theme	osteogenic	1765:1774	arg1	capability					1776:1785	superior osteogenic capability	1756:1785	superior osteogenic capability	1756:1785	Due to synergistic effects of material-induced inflammatory microenvironment and material surface properties, IL-4-loaded samples exhibited superior osteogenic capability through co-activation of three signaling pathways.
33947577	3	2	theme	immunomodulatory	570:585	arg1	materials					587:595	immunomodulatory materials	570:595	immunomodulatory materials	570:595	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	8	3	theme	Material	1460:1467	arg1	properties					1477:1486	Material surface properties	1460:1486	Material surface properties	1460:1486	Material surface properties dominated in regulating late osteogenesis probably due to the surface chemical composition (alginate, chitosan and Ca2+, etc.).
33947577	10	4	theme	defect	1870:1875	arg1	model					1877:1881	rat bone defect model	1861:1881	rat bone defect model	1861:1881	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	9	5	theme	signaling	1818:1826	arg1	pathways					1828:1835	three signaling pathways	1812:1835	three signaling pathways	1812:1835	Due to synergistic effects of material-induced inflammatory microenvironment and material surface properties, IL-4-loaded samples exhibited superior osteogenic capability through co-activation of three signaling pathways.
33947577	10	6	from	studies	1850:1856	arg1	model					1877:1881	rat bone defect model	1861:1881	rat bone defect model	1861:1881	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	4	7	theme	nanotubes	720:728	arg1	surface					701:707	the surface	697:707	the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work	697:841	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.
33947577	2	8	theme	properties	323:332	arg1	role					265:268	specific role	256:268	specific role	256:268	However, it is still unclear what is the specific role and molecular mechanisms of macrophages and material properties in the regulation of osteogenesis.
33947577	2	8	theme	properties	323:332	arg1	mechanisms					284:293	molecular mechanisms	274:293	molecular mechanisms	274:293	However, it is still unclear what is the specific role and molecular mechanisms of macrophages and material properties in the regulation of osteogenesis.
33947577	5	9	theme	Ti	917:918	arg1	implants					920:927	the immunomodulatory Ti implants	896:927	the immunomodulatory Ti implants	896:927	The osteogenic effects and regulation mechanisms of the immunomodulatory Ti implants were investigated in vitro in different BMSCs culture modes.
33947577	6	10	theme	IL-4	1051:1054	arg1	loading					1056:1062	IL-4 loading	1051:1062	IL-4 loading	1051:1062	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading) showed better direct osteogenic ability than TNTs by promoting biomineralization and up-regulating osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs.
33947577	7	11	theme	material-induced	1233:1248	arg1	M2					1282:1283	M2	1282:1283	M2	1282:1283	Notably, material-induced macrophage polarization, M1 and M2, enhanced early and mid-stage osteogenesis of BMSCs via distinct pathways: M1 activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway.
33947577	7	11	theme	material-induced	1233:1248	arg1	M1					1275:1276	M1	1275:1276	M1	1275:1276	Notably, material-induced macrophage polarization, M1 and M2, enhanced early and mid-stage osteogenesis of BMSCs via distinct pathways: M1 activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway.
33947577	7	11	theme	material-induced	1233:1248	arg1	polarization					1261:1272	material-induced macrophage polarization	1233:1272	material-induced macrophage polarization	1233:1272	Notably, material-induced macrophage polarization, M1 and M2, enhanced early and mid-stage osteogenesis of BMSCs via distinct pathways: M1 activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway.
33947577	8	12	theme	chemical	1558:1565	arg1	composition					1567:1577	the surface chemical composition	1546:1577	the surface chemical composition (alginate, chitosan and Ca2+, etc.)	1546:1613	Material surface properties dominated in regulating late osteogenesis probably due to the surface chemical composition (alginate, chitosan and Ca2+, etc.).
33947577	4	13	theme	interleukin	793:803	arg1	IL					806:807	an anti-inflammatory cytokine interleukin (IL)-4	763:810	an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work	763:841	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.
33947577	1	14	theme	macrophages	131:141	arg1	essentiality					115:126	The essentiality	111:126	The essentiality of macrophages for biomaterial-mediated osteogenesis	111:179	The essentiality of macrophages for biomaterial-mediated osteogenesis has been increasingly recognized.
33947577	4	15	theme	IL	806:807	arg1	release					752:758	the release	748:758	the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work	748:841	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.
33947577	2	16	theme	molecular	274:282	arg1	mechanisms					284:293	molecular mechanisms	274:293	molecular mechanisms	274:293	However, it is still unclear what is the specific role and molecular mechanisms of macrophages and material properties in the regulation of osteogenesis.
33947577	1	17	theme	biomaterial-mediated	147:166	arg1	osteogenesis					168:179	biomaterial-mediated osteogenesis	147:179	biomaterial-mediated osteogenesis	147:179	The essentiality of macrophages for biomaterial-mediated osteogenesis has been increasingly recognized.
33947577	7	18	theme	mid-stage	1305:1313	arg1	osteogenesis					1315:1326	early and mid-stage osteogenesis	1295:1326	early and mid-stage osteogenesis of BMSCs	1295:1335	Notably, material-induced macrophage polarization, M1 and M2, enhanced early and mid-stage osteogenesis of BMSCs via distinct pathways: M1 activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway.
33947577	7	19	theme	macrophage	1250:1259	arg1	M2					1282:1283	M2	1282:1283	M2	1282:1283	Notably, material-induced macrophage polarization, M1 and M2, enhanced early and mid-stage osteogenesis of BMSCs via distinct pathways: M1 activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway.
33947577	7	19	theme	macrophage	1250:1259	arg1	M1					1275:1276	M1	1275:1276	M1	1275:1276	Notably, material-induced macrophage polarization, M1 and M2, enhanced early and mid-stage osteogenesis of BMSCs via distinct pathways: M1 activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway.
33947577	7	19	theme	macrophage	1250:1259	arg1	polarization					1261:1272	material-induced macrophage polarization	1233:1272	material-induced macrophage polarization	1233:1272	Notably, material-induced macrophage polarization, M1 and M2, enhanced early and mid-stage osteogenesis of BMSCs via distinct pathways: M1 activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway.
33947577	5	20	theme	BMSCs	969:973	arg1	modes					983:987	different BMSCs culture modes	959:987	different BMSCs culture modes	959:987	The osteogenic effects and regulation mechanisms of the immunomodulatory Ti implants were investigated in vitro in different BMSCs culture modes.
33947577	4	21	theme	anti-inflammatory	766:782	arg1	IL					806:807	an anti-inflammatory cytokine interleukin (IL)-4	763:810	an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work	763:841	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.
33947577	7	22	theme	early	1295:1299	arg1	osteogenesis					1315:1326	early and mid-stage osteogenesis	1295:1326	early and mid-stage osteogenesis of BMSCs	1295:1335	Notably, material-induced macrophage polarization, M1 and M2, enhanced early and mid-stage osteogenesis of BMSCs via distinct pathways: M1 activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway.
33947577	6	23	theme	osteogenic	1086:1095	arg1	ability					1097:1103	better direct osteogenic ability	1072:1103	better direct osteogenic ability	1072:1103	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading) showed better direct osteogenic ability than TNTs by promoting biomineralization and up-regulating osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs.
33947577	4	24	theme	previous	829:836	arg1	work					838:841	our previous work	825:841	our previous work	825:841	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.
33947577	10	25	dep	in	1842:1843	arg1	vivo					1845:1848	vivo	1845:1848	vivo	1845:1848	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	7	26	dep	pathways	1350:1357	arg1	activated					1363:1371	activated	1363:1371	activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway	1363:1457	Notably, material-induced macrophage polarization, M1 and M2, enhanced early and mid-stage osteogenesis of BMSCs via distinct pathways: M1 activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway.
33947577	6	27	theme	better	1072:1077	arg1	ability					1097:1103	better direct osteogenic ability	1072:1103	better direct osteogenic ability	1072:1103	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading) showed better direct osteogenic ability than TNTs by promoting biomineralization and up-regulating osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs.
33947577	6	28	dep	expression	1180:1189	arg1	OCN					1209:1211	OCN	1209:1211	OCN	1209:1211	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading) showed better direct osteogenic ability than TNTs by promoting biomineralization and up-regulating osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs.
33947577	6	28	dep	expression	1180:1189	arg1	OPN					1204:1206	OPN	1204:1206	OPN	1204:1206	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading) showed better direct osteogenic ability than TNTs by promoting biomineralization and up-regulating osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs.
33947577	6	28	dep	expression	1180:1189	arg1	ALP					1199:1201	ALP	1199:1201	ALP	1199:1201	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading) showed better direct osteogenic ability than TNTs by promoting biomineralization and up-regulating osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs.
33947577	6	28	dep	expression	1180:1189	arg1	BMP1α					1192:1196	BMP1α	1192:1196	BMP1α	1192:1196	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading) showed better direct osteogenic ability than TNTs by promoting biomineralization and up-regulating osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs.
33947577	9	29	theme	inflammatory	1663:1674	arg1	microenvironment					1676:1691	material-induced inflammatory microenvironment	1646:1691	material-induced inflammatory microenvironment	1646:1691	Due to synergistic effects of material-induced inflammatory microenvironment and material surface properties, IL-4-loaded samples exhibited superior osteogenic capability through co-activation of three signaling pathways.
33947577	6	30	theme	gene	1175:1178	arg1	expression					1180:1189	osteogenic gene expression	1164:1189	osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs	1164:1221	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading) showed better direct osteogenic ability than TNTs by promoting biomineralization and up-regulating osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs.
33947577	4	31	theme	Ti	631:632	arg1	implant					634:640	an immunomodulatory Ti implant	611:640	an immunomodulatory Ti implant	611:640	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.
33947577	3	32	theme	bone	508:511	arg1	materials					524:532	bone substitute materials	508:532	bone substitute materials from immunosuppressive materials	508:565	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	0	33	theme	immunomodulatory	27:42	arg1	implants					53:60	immunomodulatory titanium implants	27:60	immunomodulatory titanium implants for promoting osteogenesis in vitro and in vivo	27:108	Alginate/chitosan modified immunomodulatory titanium implants for promoting osteogenesis in vitro and in vivo.
33947577	2	34	from	mechanisms	284:293	arg1	regulation					341:350	the regulation	337:350	the regulation of osteogenesis	337:366	However, it is still unclear what is the specific role and molecular mechanisms of macrophages and material properties in the regulation of osteogenesis.
33947577	5	35	theme	osteogenic	848:857	arg1	effects					859:865	The osteogenic effects	844:865	The osteogenic effects	844:865	The osteogenic effects and regulation mechanisms of the immunomodulatory Ti implants were investigated in vitro in different BMSCs culture modes.
33947577	8	36	dep	composition	1567:1577	arg1	alginate					1580:1587	alginate	1580:1587	alginate	1580:1587	Material surface properties dominated in regulating late osteogenesis probably due to the surface chemical composition (alginate, chitosan and Ca2+, etc.).
33947577	8	36	dep	composition	1567:1577	arg1	etc					1609:1611	etc	1609:1611	etc	1609:1611	Material surface properties dominated in regulating late osteogenesis probably due to the surface chemical composition (alginate, chitosan and Ca2+, etc.).
33947577	8	36	dep	composition	1567:1577	arg1	Ca2+					1603:1606	Ca2+	1603:1606	Ca2+	1603:1606	Material surface properties dominated in regulating late osteogenesis probably due to the surface chemical composition (alginate, chitosan and Ca2+, etc.).
33947577	8	36	dep	composition	1567:1577	arg1	chitosan					1590:1597	chitosan	1590:1597	chitosan	1590:1597	Material surface properties dominated in regulating late osteogenesis probably due to the surface chemical composition (alginate, chitosan and Ca2+, etc.).
33947577	9	37	theme	surface	1706:1712	arg1	properties					1714:1723	material surface properties	1697:1723	material surface properties	1697:1723	Due to synergistic effects of material-induced inflammatory microenvironment and material surface properties, IL-4-loaded samples exhibited superior osteogenic capability through co-activation of three signaling pathways.
33947577	10	38	theme	anti-inflammatory	2018:2034	arg1	M2					2036:2037	anti-inflammatory M2	2018:2037	anti-inflammatory M2	2018:2037	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	8	39	theme	late	1512:1515	arg1	osteogenesis					1517:1528	late osteogenesis	1512:1528	late osteogenesis	1512:1528	Material surface properties dominated in regulating late osteogenesis probably due to the surface chemical composition (alginate, chitosan and Ca2+, etc.).
33947577	3	40	theme	immunosuppressive	539:555	arg1	materials					557:565	immunosuppressive materials	539:565	immunosuppressive materials	539:565	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	10	41	theme	bone	2069:2072	arg1	formation					2074:2082	new bone formation	2065:2082	new bone formation	2065:2082	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	2	42	theme	osteogenesis	355:366	arg1	regulation					341:350	the regulation	337:350	the regulation of osteogenesis	337:366	However, it is still unclear what is the specific role and molecular mechanisms of macrophages and material properties in the regulation of osteogenesis.
33947577	10	43	theme	bone	1865:1868	arg1	model					1877:1881	rat bone defect model	1861:1881	rat bone defect model	1861:1881	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	9	44	theme	superior	1756:1763	arg1	capability					1776:1785	superior osteogenic capability	1756:1785	superior osteogenic capability	1756:1785	Due to synergistic effects of material-induced inflammatory microenvironment and material surface properties, IL-4-loaded samples exhibited superior osteogenic capability through co-activation of three signaling pathways.
33947577	6	45	theme	Alginate/chitosan	990:1006	arg1	samples					1026:1032	Alginate/chitosan multilayer-coated samples	990:1032	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading)	990:1063	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading) showed better direct osteogenic ability than TNTs by promoting biomineralization and up-regulating osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs.
33947577	4	46	theme	multilayer	661:670	arg1	films					672:676	alginate/chitosan multilayer films	643:676	alginate/chitosan multilayer films	643:676	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.
33947577	2	47	theme	material	314:321	arg1	properties					323:332	material properties	314:332	material properties	314:332	However, it is still unclear what is the specific role and molecular mechanisms of macrophages and material properties in the regulation of osteogenesis.
33947577	2	48	theme	macrophages	298:308	arg1	role					265:268	specific role	256:268	specific role	256:268	However, it is still unclear what is the specific role and molecular mechanisms of macrophages and material properties in the regulation of osteogenesis.
33947577	2	48	theme	macrophages	298:308	arg1	mechanisms					284:293	molecular mechanisms	274:293	molecular mechanisms	274:293	However, it is still unclear what is the specific role and molecular mechanisms of macrophages and material properties in the regulation of osteogenesis.
33947577	2	49	dep	role	265:268	arg1	the					252:254	the	252:254	the	252:254	However, it is still unclear what is the specific role and molecular mechanisms of macrophages and material properties in the regulation of osteogenesis.
33947577	9	50	theme	pathways	1828:1835	arg1	co-activation					1795:1807	co-activation	1795:1807	co-activation of three signaling pathways	1795:1835	Due to synergistic effects of material-induced inflammatory microenvironment and material surface properties, IL-4-loaded samples exhibited superior osteogenic capability through co-activation of three signaling pathways.
33947577	3	51	from	materials	557:565	arg1	materials					524:532	bone substitute materials	508:532	bone substitute materials from immunosuppressive materials	508:565	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	3	51	from	materials	557:565	arg1	field					393:397	an interdisciplinary field	372:397	an interdisciplinary field exploring the cross-talk between immune and skeletal systems	372:458	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	3	51	from	materials	557:565	arg1	perspective					493:503	the perspective	489:503	the perspective of bone substitute materials from immunosuppressive materials	489:565	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	10	52	theme	immunomodulatory	1909:1924	arg1	implants					1926:1933	IL-4-loaded immunomodulatory implants	1897:1933	IL-4-loaded immunomodulatory implants	1897:1933	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	5	53	theme	immunomodulatory	900:915	arg1	implants					920:927	the immunomodulatory Ti implants	896:927	the immunomodulatory Ti implants	896:927	The osteogenic effects and regulation mechanisms of the immunomodulatory Ti implants were investigated in vitro in different BMSCs culture modes.
33947577	8	54	theme	surface	1550:1556	arg1	composition					1567:1577	the surface chemical composition	1546:1577	the surface chemical composition (alginate, chitosan and Ca2+, etc.)	1546:1613	Material surface properties dominated in regulating late osteogenesis probably due to the surface chemical composition (alginate, chitosan and Ca2+, etc.).
33947577	6	55	theme	BMSCs	1217:1221	arg1	expression					1180:1189	osteogenic gene expression	1164:1189	osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs	1164:1221	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading) showed better direct osteogenic ability than TNTs by promoting biomineralization and up-regulating osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs.
33947577	4	56	theme	titania	712:718	arg1	TNTs					731:734	TNTs	731:734	TNTs	731:734	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.
33947577	4	56	theme	titania	712:718	arg1	nanotubes					720:728	titania nanotubes	712:728	titania nanotubes (TNTs)	712:735	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.
33947577	2	57	theme	specific	256:263	arg1	role					265:268	specific role	256:268	specific role	256:268	However, it is still unclear what is the specific role and molecular mechanisms of macrophages and material properties in the regulation of osteogenesis.
33947577	5	58	theme	implants	920:927	arg1	effects					859:865	The osteogenic effects	844:865	The osteogenic effects	844:865	The osteogenic effects and regulation mechanisms of the immunomodulatory Ti implants were investigated in vitro in different BMSCs culture modes.
33947577	5	58	theme	implants	920:927	arg1	mechanisms					882:891	regulation mechanisms	871:891	regulation mechanisms	871:891	The osteogenic effects and regulation mechanisms of the immunomodulatory Ti implants were investigated in vitro in different BMSCs culture modes.
33947577	10	59	theme	macrophage	1957:1966	arg1	transition					1979:1988	macrophage phenotypic transition	1957:1988	macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2	1957:2037	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	4	60	theme	cytokine	784:791	arg1	IL					806:807	an anti-inflammatory cytokine interleukin (IL)-4	763:810	an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work	763:841	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.
33947577	3	61	theme	materials	524:532	arg1	field					393:397	an interdisciplinary field	372:397	an interdisciplinary field exploring the cross-talk between immune and skeletal systems	372:458	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	3	61	theme	materials	524:532	arg1	perspective					493:503	the perspective	489:503	the perspective of bone substitute materials from immunosuppressive materials	489:565	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	10	62	theme	pro-inflammatory	1995:2010	arg1	M1					2012:2013	pro-inflammatory M1	1995:2013	pro-inflammatory M1	1995:2013	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	5	63	theme	different	959:967	arg1	modes					983:987	different BMSCs culture modes	959:987	different BMSCs culture modes	959:987	The osteogenic effects and regulation mechanisms of the immunomodulatory Ti implants were investigated in vitro in different BMSCs culture modes.
33947577	5	64	theme	culture	975:981	arg1	modes					983:987	different BMSCs culture modes	959:987	different BMSCs culture modes	959:987	The osteogenic effects and regulation mechanisms of the immunomodulatory Ti implants were investigated in vitro in different BMSCs culture modes.
33947577	3	65	dep	materials	524:532	arg1	substitute					513:522	substitute	513:522	substitute	513:522	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	10	66	theme	IL-4-loaded	1897:1907	arg1	implants					1926:1933	IL-4-loaded immunomodulatory implants	1897:1933	IL-4-loaded immunomodulatory implants	1897:1933	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	6	67	theme	direct	1079:1084	arg1	ability					1097:1103	better direct osteogenic ability	1072:1103	better direct osteogenic ability	1072:1103	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading) showed better direct osteogenic ability than TNTs by promoting biomineralization and up-regulating osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs.
33947577	9	68	theme	synergistic	1623:1633	arg1	effects					1635:1641	synergistic effects	1623:1641	synergistic effects of material-induced inflammatory microenvironment and material surface properties	1623:1723	Due to synergistic effects of material-induced inflammatory microenvironment and material surface properties, IL-4-loaded samples exhibited superior osteogenic capability through co-activation of three signaling pathways.
33947577	3	69	theme	interdisciplinary	375:391	arg1	field					393:397	an interdisciplinary field	372:397	an interdisciplinary field exploring the cross-talk between immune and skeletal systems	372:458	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	3	69	theme	interdisciplinary	375:391	arg1	perspective					493:503	the perspective	489:503	the perspective of bone substitute materials from immunosuppressive materials	489:565	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	5	70	theme	regulation	871:880	arg1	mechanisms					882:891	regulation mechanisms	871:891	regulation mechanisms	871:891	The osteogenic effects and regulation mechanisms of the immunomodulatory Ti implants were investigated in vitro in different BMSCs culture modes.
33947577	9	71	theme	material-induced	1646:1661	arg1	microenvironment					1676:1691	material-induced inflammatory microenvironment	1646:1691	material-induced inflammatory microenvironment	1646:1691	Due to synergistic effects of material-induced inflammatory microenvironment and material surface properties, IL-4-loaded samples exhibited superior osteogenic capability through co-activation of three signaling pathways.
33947577	7	72	theme	Wnt10b/β-catenin	1393:1408	arg1	pathways					1410:1417	Wnt10b/β-catenin pathways	1393:1417	Wnt10b/β-catenin pathways	1393:1417	Notably, material-induced macrophage polarization, M1 and M2, enhanced early and mid-stage osteogenesis of BMSCs via distinct pathways: M1 activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway.
33947577	3	73	theme	immune	432:437	arg1	systems					452:458	immune and skeletal systems	432:458	immune and skeletal systems	432:458	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	0	74	theme	titanium	44:51	arg1	implants					53:60	immunomodulatory titanium implants	27:60	immunomodulatory titanium implants for promoting osteogenesis in vitro and in vivo	27:108	Alginate/chitosan modified immunomodulatory titanium implants for promoting osteogenesis in vitro and in vivo.
33947577	9	75	theme	microenvironment	1676:1691	arg1	effects					1635:1641	synergistic effects	1623:1641	synergistic effects of material-induced inflammatory microenvironment and material surface properties	1623:1723	Due to synergistic effects of material-induced inflammatory microenvironment and material surface properties, IL-4-loaded samples exhibited superior osteogenic capability through co-activation of three signaling pathways.
33947577	2	76	from	role	265:268	arg1	regulation					341:350	the regulation	337:350	the regulation of osteogenesis	337:366	However, it is still unclear what is the specific role and molecular mechanisms of macrophages and material properties in the regulation of osteogenesis.
33947577	6	77	theme	osteogenic	1164:1173	arg1	expression					1180:1189	osteogenic gene expression	1164:1189	osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs	1164:1221	Alginate/chitosan multilayer-coated samples (with or without IL-4 loading) showed better direct osteogenic ability than TNTs by promoting biomineralization and up-regulating osteogenic gene expression (BMP1α, ALP, OPN, OCN) of BMSCs.
33947577	4	78	theme	alginate/chitosan	643:659	arg1	films					672:676	alginate/chitosan multilayer films	643:676	alginate/chitosan multilayer films	643:676	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.
33947577	8	79	theme	surface	1469:1475	arg1	properties					1477:1486	Material surface properties	1460:1486	Material surface properties	1460:1486	Material surface properties dominated in regulating late osteogenesis probably due to the surface chemical composition (alginate, chitosan and Ca2+, etc.).
33947577	9	80	theme	material	1697:1704	arg1	properties					1714:1723	material surface properties	1697:1723	material surface properties	1697:1723	Due to synergistic effects of material-induced inflammatory microenvironment and material surface properties, IL-4-loaded samples exhibited superior osteogenic capability through co-activation of three signaling pathways.
33947577	10	81	from	M1	2012:2013	arg1	transition					1979:1988	macrophage phenotypic transition	1957:1988	macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2	1957:2037	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	3	82	from	perspective	493:503	arg1	materials					557:565	immunosuppressive materials	539:565	immunosuppressive materials	539:565	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	9	83	theme	properties	1714:1723	arg1	effects					1635:1641	synergistic effects	1623:1641	synergistic effects of material-induced inflammatory microenvironment and material surface properties	1623:1723	Due to synergistic effects of material-induced inflammatory microenvironment and material surface properties, IL-4-loaded samples exhibited superior osteogenic capability through co-activation of three signaling pathways.
33947577	3	84	theme	skeletal	443:450	arg1	systems					452:458	immune and skeletal systems	432:458	immune and skeletal systems	432:458	As an interdisciplinary field exploring the cross-talk between immune and skeletal systems, osteoimmunology has shifted the perspective of bone substitute materials from immunosuppressive materials to immunomodulatory materials.
33947577	4	85	theme	immunomodulatory	614:629	arg1	implant					634:640	an immunomodulatory Ti implant	611:640	an immunomodulatory Ti implant	611:640	To fabricate an immunomodulatory Ti implant, alginate/chitosan multilayer films were fabricated on the surface of titania nanotubes (TNTs) to control the release of an anti-inflammatory cytokine interleukin (IL)-4 according to our previous work.
33947577	10	86	theme	in	1842:1843	arg1	studies					1850:1856	The in vivo studies	1838:1856	The in vivo studies in rat bone defect model	1838:1881	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	9	87	theme	IL-4-loaded	1726:1736	arg1	samples					1738:1744	IL-4-loaded samples	1726:1744	IL-4-loaded samples	1726:1744	Due to synergistic effects of material-induced inflammatory microenvironment and material surface properties, IL-4-loaded samples exhibited superior osteogenic capability through co-activation of three signaling pathways.
33947577	10	88	theme	phenotypic	1968:1977	arg1	transition					1979:1988	macrophage phenotypic transition	1957:1988	macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2	1957:2037	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	7	89	theme	distinct	1341:1348	arg1	pathways					1350:1357	distinct pathways	1341:1357	distinct pathways: M1 activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway	1341:1457	Notably, material-induced macrophage polarization, M1 and M2, enhanced early and mid-stage osteogenesis of BMSCs via distinct pathways: M1 activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway.
33947577	10	90	theme	new	2065:2067	arg1	formation					2074:2082	new bone formation	2065:2082	new bone formation	2065:2082	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
33947577	7	91	theme	BMSCs	1331:1335	arg1	osteogenesis					1315:1326	early and mid-stage osteogenesis	1295:1326	early and mid-stage osteogenesis of BMSCs	1295:1335	Notably, material-induced macrophage polarization, M1 and M2, enhanced early and mid-stage osteogenesis of BMSCs via distinct pathways: M1 activated both BMP6/SMADs and Wnt10b/β-catenin pathways; while M2 activated TGF-β/SMADs pathway.
33947577	10	92	theme	rat	1861:1863	arg1	model					1877:1881	rat bone defect model	1861:1881	rat bone defect model	1861:1881	The in vivo studies in rat bone defect model revealed that IL-4-loaded immunomodulatory implants successfully achieved macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2 and subsequently improved new bone formation.
32987938	2	0	theme	high	501:504	arg1	loading					514:520	high and low loading	501:520	high and low loading of the protein, which served as sensor and reference regions respectively	501:594	Streptavidin attached to the chitosan via the photocleavable linker was selectively removed by shining 365 nm light through a photomask to create an array of strips with high and low loading of the protein, which served as sensor and reference regions respectively.
32987938	3	1	used	used	669:672	arg2	measurements					614:625	The differential measurements	597:625	The differential measurements between sensor and reference regions	597:662	The differential measurements between sensor and reference regions were used for measuring analytes (i.e., biotin protein A and IgG) while reducing environmental and non-specific effects.
32987938	6	2	theme	sample	1291:1296	arg1	analysis					1298:1305	sample analysis	1291:1305	sample analysis	1291:1305	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	2	3	theme	photocleavable	377:390	arg1	linker					392:397	the photocleavable linker	373:397	the photocleavable linker	373:397	Streptavidin attached to the chitosan via the photocleavable linker was selectively removed by shining 365 nm light through a photomask to create an array of strips with high and low loading of the protein, which served as sensor and reference regions respectively.
32987938	1	4	theme	covalent	258:265	arg1	attachment					267:276	covalent attachment	258:276	covalent attachment of a biotinylated photocleavable linker to chitosan	258:328	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	3	5	theme	protein	711:717	arg1	analytes					688:695	analytes	688:695	analytes (i.e., biotin protein A and IgG)	688:728	The differential measurements between sensor and reference regions were used for measuring analytes (i.e., biotin protein A and IgG) while reducing environmental and non-specific effects.
32987938	3	5	theme	protein	711:717	arg1	A					719:719	biotin protein A	704:719	biotin protein A	704:719	The differential measurements between sensor and reference regions were used for measuring analytes (i.e., biotin protein A and IgG) while reducing environmental and non-specific effects.
32987938	6	6	theme	complex	1256:1262	arg1	mixtures					1264:1271	complex mixtures	1256:1271	complex mixtures	1256:1271	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	6	6	theme	complex	1256:1262	arg1	samples					1239:1245	real samples	1234:1245	real samples that are complex mixtures	1234:1271	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	5	7	theme	diffraction-based	1080:1096	arg1	LWs					1098:1100	diffraction-based LWs	1080:1100	diffraction-based LWs for referencing	1080:1116	The novelty of this work lies in combining photofunctionalisable hydrogels with diffraction-based LWs for referencing.
32987938	6	8	from	concentrations	1216:1229	arg1	mixtures					1264:1271	complex mixtures	1256:1271	complex mixtures	1256:1271	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	6	8	from	concentrations	1216:1229	arg1	samples					1239:1245	real samples	1234:1245	real samples that are complex mixtures	1234:1271	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	2	9	theme	protein	529:535	arg1	loading					514:520	high and low loading	501:520	high and low loading of the protein, which served as sensor and reference regions respectively	501:594	Streptavidin attached to the chitosan via the photocleavable linker was selectively removed by shining 365 nm light through a photomask to create an array of strips with high and low loading of the protein, which served as sensor and reference regions respectively.
32987938	6	10	theme	biosensors	1186:1195	arg1	potential					1154:1162	the full potential	1145:1162	the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed	1145:1387	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	3	11	dep	analytes	688:695	arg1	analytes					688:695	analytes	688:695	analytes (i.e., biotin protein A and IgG)	688:728	The differential measurements between sensor and reference regions were used for measuring analytes (i.e., biotin protein A and IgG) while reducing environmental and non-specific effects.
32987938	3	11	dep	analytes	688:695	arg1	IgG					725:727	IgG	725:727	IgG	725:727	The differential measurements between sensor and reference regions were used for measuring analytes (i.e., biotin protein A and IgG) while reducing environmental and non-specific effects.
32987938	3	11	dep	analytes	688:695	arg1	A					719:719	biotin protein A	704:719	biotin protein A	704:719	The differential measurements between sensor and reference regions were used for measuring analytes (i.e., biotin protein A and IgG) while reducing environmental and non-specific effects.
32987938	6	12	theme	optical	1178:1184	arg1	biosensors					1186:1195	label-free optical biosensors	1167:1195	label-free optical biosensors	1167:1195	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	6	13	from	fluctuations	1348:1359	arg1	temperature					1364:1374	temperature	1364:1374	temperature	1364:1374	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	4	14	theme	non-adsorbing	855:867	arg1	species					883:889	non-adsorbing and adsorbing species	855:889	non-adsorbing and adsorbing species	855:889	These include changes in temperature and sample composition caused by non-adsorbing and adsorbing species, leading to reduction in effects by ~98%, ~99%, and ~97% respectively compared to the absolute measurements.
32987938	6	15	theme	label-free	1167:1176	arg1	biosensors					1186:1195	label-free optical biosensors	1167:1195	label-free optical biosensors	1167:1195	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	1	16	theme	thin	193:196	arg1	film					206:209	a thin (~2 µm) film	191:209	a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan	191:328	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	1	16	theme	thin	193:196	arg1	µm					202:203	~2 µm	199:203	~2 µm	199:203	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	2	17	theme	strips	489:494	arg1	array					480:484	an array	477:484	an array of strips with high and low loading of the protein, which served as sensor and reference regions respectively	477:594	Streptavidin attached to the chitosan via the photocleavable linker was selectively removed by shining 365 nm light through a photomask to create an array of strips with high and low loading of the protein, which served as sensor and reference regions respectively.
32987938	0	18	theme	Self-Referenced	2:16	arg1	Biosensor					60:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor	0:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor	0:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor Using Photofunctionalised Hydrogels.
32987938	4	19	theme	adsorbing	873:881	arg1	species					883:889	non-adsorbing and adsorbing species	855:889	non-adsorbing and adsorbing species	855:889	These include changes in temperature and sample composition caused by non-adsorbing and adsorbing species, leading to reduction in effects by ~98%, ~99%, and ~97% respectively compared to the absolute measurements.
32987938	3	20	theme	environmental	745:757	arg1	effects					776:782	environmental and non-specific effects	745:782	environmental and non-specific effects	745:782	The differential measurements between sensor and reference regions were used for measuring analytes (i.e., biotin protein A and IgG) while reducing environmental and non-specific effects.
32987938	6	21	dep	potential	1154:1162	arg1	allow					1281:1285	allow	1281:1285	to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed	1278:1387	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	6	21	dep	potential	1154:1162	arg1	measure					1200:1206	measure	1200:1206	to measure analyte concentrations in real samples that are complex mixtures	1197:1271	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	1	22	theme	biotinylated	283:294	arg1	linker					311:316	a biotinylated photocleavable linker	281:316	a biotinylated photocleavable linker	281:316	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	6	23	theme	full	1149:1152	arg1	potential					1154:1162	the full potential	1145:1162	the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed	1145:1387	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	0	24	theme	Optical	36:42	arg1	Biosensor					60:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor	0:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor	0:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor Using Photofunctionalised Hydrogels.
32987938	1	25	theme	photocleavable	296:309	arg1	linker					311:316	a biotinylated photocleavable linker	281:316	a biotinylated photocleavable linker	281:316	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	1	26	theme	novel	119:123	arg1	waveguide					165:173	a novel self-referenced diffraction-based leaky waveguide	117:173	a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan	117:328	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	1	26	theme	novel	119:123	arg1	LW					176:177	LW	176:177	LW	176:177	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	0	27	theme	Diffraction-Based	18:34	arg1	Biosensor					60:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor	0:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor	0:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor Using Photofunctionalised Hydrogels.
32987938	1	28	theme	linker	311:316	arg1	attachment					267:276	covalent attachment	258:276	covalent attachment of a biotinylated photocleavable linker to chitosan	258:328	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	5	29	theme	photofunctionalisable	1043:1063	arg1	hydrogels					1065:1073	photofunctionalisable hydrogels	1043:1073	photofunctionalisable hydrogels	1043:1073	The novelty of this work lies in combining photofunctionalisable hydrogels with diffraction-based LWs for referencing.
32987938	1	30	theme	self-referenced	125:139	arg1	waveguide					165:173	a novel self-referenced diffraction-based leaky waveguide	117:173	a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan	117:328	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	1	30	theme	self-referenced	125:139	arg1	LW					176:177	LW	176:177	LW	176:177	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	0	31	theme	Waveguide	50:58	arg1	Biosensor					60:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor	0:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor	0:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor Using Photofunctionalised Hydrogels.
32987938	6	32	from	drifts	1337:1342	arg1	temperature					1364:1374	temperature	1364:1374	temperature	1364:1374	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	4	33	theme	sample	826:831	arg1	composition					833:843	sample composition	826:843	sample composition	826:843	These include changes in temperature and sample composition caused by non-adsorbing and adsorbing species, leading to reduction in effects by ~98%, ~99%, and ~97% respectively compared to the absolute measurements.
32987938	2	34	theme	nm	438:439	arg1	light					441:445	365 nm light	434:445	365 nm light	434:445	Streptavidin attached to the chitosan via the photocleavable linker was selectively removed by shining 365 nm light through a photomask to create an array of strips with high and low loading of the protein, which served as sensor and reference regions respectively.
32987938	0	35	theme	Leaky	44:48	arg1	Biosensor					60:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor	0:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor	0:68	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor Using Photofunctionalised Hydrogels.
32987938	3	36	dep	A	719:719	arg1	i.e.					698:701	i.e.	698:701	i.e.	698:701	The differential measurements between sensor and reference regions were used for measuring analytes (i.e., biotin protein A and IgG) while reducing environmental and non-specific effects.
32987938	3	37	theme	reference	646:654	arg1	regions					656:662	reference regions	646:662	reference regions	646:662	The differential measurements between sensor and reference regions were used for measuring analytes (i.e., biotin protein A and IgG) while reducing environmental and non-specific effects.
32987938	3	38	theme	differential	601:612	arg1	measurements					614:625	The differential measurements	597:625	The differential measurements between sensor and reference regions	597:662	The differential measurements between sensor and reference regions were used for measuring analytes (i.e., biotin protein A and IgG) while reducing environmental and non-specific effects.
32987938	2	39	theme	365	434:436	arg1	nm					438:439	nm	438:439	nm	438:439	Streptavidin attached to the chitosan via the photocleavable linker was selectively removed by shining 365 nm light through a photomask to create an array of strips with high and low loading of the protein, which served as sensor and reference regions respectively.
32987938	2	40	attach	attached	344:351	arg1	chitosan					360:367	the chitosan	356:367	the chitosan	356:367	Streptavidin attached to the chitosan via the photocleavable linker was selectively removed by shining 365 nm light through a photomask to create an array of strips with high and low loading of the protein, which served as sensor and reference regions respectively.
32987938	2	40	attach	attached	344:351	arg2	Streptavidin					331:342	Streptavidin	331:342	Streptavidin attached to the chitosan via the photocleavable linker	331:397	Streptavidin attached to the chitosan via the photocleavable linker was selectively removed by shining 365 nm light through a photomask to create an array of strips with high and low loading of the protein, which served as sensor and reference regions respectively.
32987938	6	41	theme	real	1234:1237	arg1	mixtures					1264:1271	complex mixtures	1256:1271	complex mixtures	1256:1271	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	6	41	theme	real	1234:1237	arg1	samples					1239:1245	real samples	1234:1245	real samples that are complex mixtures	1234:1271	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	4	42	from	composition	833:843	arg1	temperature					810:820	temperature	810:820	temperature	810:820	These include changes in temperature and sample composition caused by non-adsorbing and adsorbing species, leading to reduction in effects by ~98%, ~99%, and ~97% respectively compared to the absolute measurements.
32987938	1	43	theme	diffraction-based	141:157	arg1	waveguide					165:173	a novel self-referenced diffraction-based leaky waveguide	117:173	a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan	117:328	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	1	43	theme	diffraction-based	141:157	arg1	LW					176:177	LW	176:177	LW	176:177	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	3	44	theme	non-specific	763:774	arg1	effects					776:782	environmental and non-specific effects	745:782	environmental and non-specific effects	745:782	The differential measurements between sensor and reference regions were used for measuring analytes (i.e., biotin protein A and IgG) while reducing environmental and non-specific effects.
32987938	2	45	theme	reference	565:573	arg1	protein					529:535	the protein	525:535	the protein	525:535	Streptavidin attached to the chitosan via the photocleavable linker was selectively removed by shining 365 nm light through a photomask to create an array of strips with high and low loading of the protein, which served as sensor and reference regions respectively.
32987938	2	45	theme	reference	565:573	arg1	regions					575:581	reference regions	565:581	reference regions	565:581	Streptavidin attached to the chitosan via the photocleavable linker was selectively removed by shining 365 nm light through a photomask to create an array of strips with high and low loading of the protein, which served as sensor and reference regions respectively.
32987938	5	46	theme	work	1020:1023	arg1	novelty					1004:1010	The novelty	1000:1010	The novelty of this work	1000:1023	The novelty of this work lies in combining photofunctionalisable hydrogels with diffraction-based LWs for referencing.
32987938	1	47	theme	leaky	159:163	arg1	waveguide					165:173	a novel self-referenced diffraction-based leaky waveguide	117:173	a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan	117:328	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	1	47	theme	leaky	159:163	arg1	LW					176:177	LW	176:177	LW	176:177	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	1	48	attach	attachment	267:276	arg1	chitosan					321:328	chitosan	321:328	chitosan	321:328	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	1	48	attach	attachment	267:276	arg2	linker					311:316	a biotinylated photocleavable linker	281:316	a biotinylated photocleavable linker	281:316	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	4	49	from	changes	799:805	arg1	temperature					810:820	temperature	810:820	temperature	810:820	These include changes in temperature and sample composition caused by non-adsorbing and adsorbing species, leading to reduction in effects by ~98%, ~99%, and ~97% respectively compared to the absolute measurements.
32987938	1	50	theme	photofunctionalisable	216:236	arg1	hydrogel					238:245	a photofunctionalisable hydrogel	214:245	a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan	214:328	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	4	51	theme	absolute	977:984	arg1	measurements					986:997	the absolute measurements	973:997	the absolute measurements	973:997	These include changes in temperature and sample composition caused by non-adsorbing and adsorbing species, leading to reduction in effects by ~98%, ~99%, and ~97% respectively compared to the absolute measurements.
32987938	6	52	theme	analyte	1208:1214	arg1	concentrations					1216:1229	analyte concentrations	1208:1229	analyte concentrations in real samples that are complex mixtures	1208:1271	This is needed to realise the full potential of label-free optical biosensors to measure analyte concentrations in real samples that are complex mixtures, and to allow for sample analysis outside of laboratories where drifts and fluctuations in temperature are observed.
32987938	1	53	theme	hydrogel	238:245	arg1	film					206:209	a thin (~2 µm) film	191:209	a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan	191:328	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	1	53	theme	hydrogel	238:245	arg1	µm					202:203	~2 µm	199:203	~2 µm	199:203	We report a novel self-referenced diffraction-based leaky waveguide (LW) comprising a thin (~2 µm) film of a photofunctionalisable hydrogel created by covalent attachment of a biotinylated photocleavable linker to chitosan.
32987938	2	54	theme	low	510:512	arg1	loading					514:520	high and low loading	501:520	high and low loading of the protein, which served as sensor and reference regions respectively	501:594	Streptavidin attached to the chitosan via the photocleavable linker was selectively removed by shining 365 nm light through a photomask to create an array of strips with high and low loading of the protein, which served as sensor and reference regions respectively.
32987938	4	55	from	reduction	903:911	arg1	effects					916:922	effects	916:922	effects	916:922	These include changes in temperature and sample composition caused by non-adsorbing and adsorbing species, leading to reduction in effects by ~98%, ~99%, and ~97% respectively compared to the absolute measurements.
32987938	0	56	theme	Photofunctionalised	76:94	arg1	Hydrogels					96:104	Photofunctionalised Hydrogels	76:104	Photofunctionalised Hydrogels	76:104	A Self-Referenced Diffraction-Based Optical Leaky Waveguide Biosensor Using Photofunctionalised Hydrogels.
32987938	3	57	theme	biotin	704:709	arg1	analytes					688:695	analytes	688:695	analytes (i.e., biotin protein A and IgG)	688:728	The differential measurements between sensor and reference regions were used for measuring analytes (i.e., biotin protein A and IgG) while reducing environmental and non-specific effects.
32987938	3	57	theme	biotin	704:709	arg1	A					719:719	biotin protein A	704:719	biotin protein A	704:719	The differential measurements between sensor and reference regions were used for measuring analytes (i.e., biotin protein A and IgG) while reducing environmental and non-specific effects.
32987938	2	58	with	strips	489:494	arg1	loading					514:520	high and low loading	501:520	high and low loading of the protein, which served as sensor and reference regions respectively	501:594	Streptavidin attached to the chitosan via the photocleavable linker was selectively removed by shining 365 nm light through a photomask to create an array of strips with high and low loading of the protein, which served as sensor and reference regions respectively.
34229786	7	0	theme	performance	1142:1152	arg1	study					1120:1124	the study	1116:1124	the study of drug release performance to identify their future feasibility	1116:1189	Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
34229786	3	1	theme	CS	516:517	arg1	applications					500:511	the applications	496:511	the applications of CS	496:517	To solve this problem and extend the applications of CS, polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers were successfully prepared as drug carriers in this study via electrospinning.
34229786	7	2	theme	ofloxacin	1103:1111	arg1	carriers					1091:1098	carriers	1091:1098	carriers of ofloxacin	1091:1111	Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
34229786	7	2	theme	ofloxacin	1103:1111	arg1	membranes					1048:1056	the membranes	1044:1056	the membranes with optimum ratios	1044:1076	Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
34229786	1	3	theme	excellent	245:253	arg1	biodegradability					255:270	its excellent biodegradability	241:270	its excellent biodegradability	241:270	Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility.
34229786	7	4	theme	drug	1129:1132	arg1	performance					1142:1152	drug release performance	1129:1152	drug release performance	1129:1152	Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
34229786	1	5	from	nature	168:173	arg1	available					155:163	available	155:163	available	155:163	Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility.
34229786	6	6	with	smoother	982:989	arg1	beads					1001:1005	beads	1001:1005	beads	1001:1005	The morphology of the optimum membranes with the ratio of 1:0.13:0.67 was smoother with less beads and uniform fiber diameter.
34229786	6	6	with	smoother	982:989	arg1	diameter					1025:1032	uniform fiber diameter	1011:1032	uniform fiber diameter	1011:1032	The morphology of the optimum membranes with the ratio of 1:0.13:0.67 was smoother with less beads and uniform fiber diameter.
34229786	7	7	with	membranes	1048:1056	arg1	ratios					1071:1076	optimum ratios	1063:1076	optimum ratios	1063:1076	Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
34229786	6	8	theme	membranes	938:946	arg1	smoother					982:989	smoother	982:989	smoother	982:989	The morphology of the optimum membranes with the ratio of 1:0.13:0.67 was smoother with less beads and uniform fiber diameter.
34229786	6	8	theme	membranes	938:946	arg1	morphology					912:921	The morphology	908:921	The morphology of the optimum membranes with the ratio of 1:0.13:0.67	908:976	The morphology of the optimum membranes with the ratio of 1:0.13:0.67 was smoother with less beads and uniform fiber diameter.
34229786	7	9	theme	release	1134:1140	arg1	performance					1142:1152	drug release performance	1129:1152	drug release performance	1129:1152	Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
34229786	3	10	theme	composite	577:585	arg1	carriers					633:640	drug carriers	628:640	drug carriers in this study	628:654	To solve this problem and extend the applications of CS, polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers were successfully prepared as drug carriers in this study via electrospinning.
34229786	3	10	theme	composite	577:585	arg1	nanofibers					587:596	polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers	520:596	polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers	520:596	To solve this problem and extend the applications of CS, polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers were successfully prepared as drug carriers in this study via electrospinning.
34229786	6	11	theme	fiber	1019:1023	arg1	diameter					1025:1032	uniform fiber diameter	1011:1032	uniform fiber diameter	1011:1032	The morphology of the optimum membranes with the ratio of 1:0.13:0.67 was smoother with less beads and uniform fiber diameter.
34229786	7	12	theme	initial	1210:1216	arg1	release					1223:1229	an initial fast release	1207:1229	an initial fast release followed by a relatively stable release	1207:1269	Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
34229786	6	13	theme	optimum	930:936	arg1	membranes					938:946	the optimum membranes	926:946	the optimum membranes with the ratio of 1:0.13:0.67	926:976	The morphology of the optimum membranes with the ratio of 1:0.13:0.67 was smoother with less beads and uniform fiber diameter.
34229786	1	14	theme	promising	194:202	arg1	candidate					204:212	a promising candidate	192:212	a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility	192:291	Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility.
34229786	1	14	theme	promising	194:202	arg1	Chitosan					107:114	Chitosan	107:114	Chitosan (CS)	107:119	Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility.
34229786	7	15	theme	fast	1218:1221	arg1	release					1223:1229	an initial fast release	1207:1229	an initial fast release followed by a relatively stable release	1207:1269	Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
34229786	5	16	dep	decreased	847:855	arg1	determined					858:867	determined	858:867	determined by scanning electron microscopy (SEM)	858:905	As the content of each was increased, the beads among the membranes increased initially and then decreased, determined by scanning electron microscopy (SEM).
34229786	3	17	theme	PA/CS/TEOS	565:574	arg1	carriers					633:640	drug carriers	628:640	drug carriers in this study	628:654	To solve this problem and extend the applications of CS, polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers were successfully prepared as drug carriers in this study via electrospinning.
34229786	3	17	theme	PA/CS/TEOS	565:574	arg1	nanofibers					587:596	polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers	520:596	polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers	520:596	To solve this problem and extend the applications of CS, polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers were successfully prepared as drug carriers in this study via electrospinning.
34229786	2	18	theme	efficient	401:409	arg1	electrospinning					372:386	electrospinning	372:386	electrospinning	372:386	However, inherent solubility and polycationic properties of CS largely hinder electrospinning, which is an efficient method of fabricating nanofibers for drug carriers.
34229786	2	18	theme	efficient	401:409	arg1	method					411:416	an efficient method	398:416	an efficient method of fabricating nanofibers for drug carriers	398:460	However, inherent solubility and polycationic properties of CS largely hinder electrospinning, which is an efficient method of fabricating nanofibers for drug carriers.
34229786	2	19	theme	polycationic	327:338	arg1	properties					340:349	polycationic properties	327:349	polycationic properties of CS	327:355	However, inherent solubility and polycationic properties of CS largely hinder electrospinning, which is an efficient method of fabricating nanofibers for drug carriers.
34229786	4	20	theme	nanofiber	728:736	arg1	morphology					738:747	the nanofiber morphology	724:747	the nanofiber morphology	724:747	The PA/CS/TEOS ratios significantly influenced the nanofiber morphology.
34229786	6	21	theme	uniform	1011:1017	arg1	diameter					1025:1032	uniform fiber diameter	1011:1032	uniform fiber diameter	1011:1032	The morphology of the optimum membranes with the ratio of 1:0.13:0.67 was smoother with less beads and uniform fiber diameter.
34229786	1	22	from	available	155:163	arg1	nature					168:173	nature	168:173	nature	168:173	Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility.
34229786	5	23	theme	electron	881:888	arg1	SEM					902:904	SEM	902:904	SEM	902:904	As the content of each was increased, the beads among the membranes increased initially and then decreased, determined by scanning electron microscopy (SEM).
34229786	5	23	theme	electron	881:888	arg1	microscopy					890:899	scanning electron microscopy	872:899	scanning electron microscopy (SEM)	872:905	As the content of each was increased, the beads among the membranes increased initially and then decreased, determined by scanning electron microscopy (SEM).
34229786	2	24	theme	drug	448:451	arg1	carriers					453:460	drug carriers	448:460	drug carriers	448:460	However, inherent solubility and polycationic properties of CS largely hinder electrospinning, which is an efficient method of fabricating nanofibers for drug carriers.
34229786	5	25	dep	increased	818:826	arg1	decreased					847:855	decreased	847:855	decreased	847:855	As the content of each was increased, the beads among the membranes increased initially and then decreased, determined by scanning electron microscopy (SEM).
34229786	2	26	theme	inherent	303:310	arg1	solubility					312:321	inherent solubility	303:321	inherent solubility	303:321	However, inherent solubility and polycationic properties of CS largely hinder electrospinning, which is an efficient method of fabricating nanofibers for drug carriers.
34229786	3	27	from	carriers	633:640	arg1	study					650:654	this study	645:654	this study	645:654	To solve this problem and extend the applications of CS, polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers were successfully prepared as drug carriers in this study via electrospinning.
34229786	2	28	theme	nanofibers	433:442	arg1	electrospinning					372:386	electrospinning	372:386	electrospinning	372:386	However, inherent solubility and polycationic properties of CS largely hinder electrospinning, which is an efficient method of fabricating nanofibers for drug carriers.
34229786	2	28	theme	nanofibers	433:442	arg1	method					411:416	an efficient method	398:416	an efficient method of fabricating nanofibers for drug carriers	398:460	However, inherent solubility and polycationic properties of CS largely hinder electrospinning, which is an efficient method of fabricating nanofibers for drug carriers.
34229786	7	29	theme	future	1172:1177	arg1	feasibility					1179:1189	their future feasibility	1166:1189	their future feasibility	1166:1189	Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
34229786	5	30	theme	each	768:771	arg1	content					757:763	the content	753:763	the content of each	753:771	As the content of each was increased, the beads among the membranes increased initially and then decreased, determined by scanning electron microscopy (SEM).
34229786	2	31	theme	fabricating	421:431	arg1	nanofibers					433:442	fabricating nanofibers	421:442	fabricating nanofibers	421:442	However, inherent solubility and polycationic properties of CS largely hinder electrospinning, which is an efficient method of fabricating nanofibers for drug carriers.
34229786	4	32	theme	PA/CS/TEOS	681:690	arg1	ratios					692:697	The PA/CS/TEOS ratios	677:697	The PA/CS/TEOS ratios	677:697	The PA/CS/TEOS ratios significantly influenced the nanofiber morphology.
34229786	7	33	used	used	1083:1086	arg2	carriers					1091:1098	carriers	1091:1098	carriers of ofloxacin	1091:1111	Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
34229786	7	33	used	used	1083:1086	arg2	membranes					1048:1056	the membranes	1044:1056	the membranes with optimum ratios	1044:1076	Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
34229786	7	34	theme	stable	1256:1261	arg1	release					1263:1269	a relatively stable release	1243:1269	a relatively stable release	1243:1269	Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
34229786	0	35	theme	Novel	73:77	arg1	Carrier					98:104	a Novel and Promising Drug Carrier	71:104	a Novel and Promising Drug Carrier	71:104	Polyamide/Chitosan/Tetraethyl Orthosilicate Electrospun Nanofibers for a Novel and Promising Drug Carrier.
34229786	3	36	theme	drug	628:631	arg1	carriers					633:640	drug carriers	628:640	drug carriers in this study	628:654	To solve this problem and extend the applications of CS, polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers were successfully prepared as drug carriers in this study via electrospinning.
34229786	3	36	theme	drug	628:631	arg1	nanofibers					587:596	polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers	520:596	polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers	520:596	To solve this problem and extend the applications of CS, polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers were successfully prepared as drug carriers in this study via electrospinning.
34229786	2	37	theme	CS	354:355	arg1	solubility					312:321	inherent solubility	303:321	inherent solubility	303:321	However, inherent solubility and polycationic properties of CS largely hinder electrospinning, which is an efficient method of fabricating nanofibers for drug carriers.
34229786	2	37	theme	CS	354:355	arg1	properties					340:349	polycationic properties	327:349	polycationic properties of CS	327:355	However, inherent solubility and polycationic properties of CS largely hinder electrospinning, which is an efficient method of fabricating nanofibers for drug carriers.
34229786	6	38	theme	1:0.13:0.67	966:976	arg1	ratio					957:961	the ratio	953:961	the ratio of 1:0.13:0.67	953:976	The morphology of the optimum membranes with the ratio of 1:0.13:0.67 was smoother with less beads and uniform fiber diameter.
34229786	7	39	theme	optimum	1063:1069	arg1	ratios					1071:1076	optimum ratios	1063:1076	optimum ratios	1063:1076	Finally, the membranes with optimum ratios were used as carriers of ofloxacin in the study of drug release performance to identify their future feasibility, which revealed an initial fast release followed by a relatively stable release.
34229786	1	40	theme	only	126:129	arg1	Chitosan					107:114	Chitosan	107:114	Chitosan (CS)	107:119	Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility.
34229786	1	40	theme	only	126:129	arg1	polysaccharose					140:153	the only alkaline polysaccharose	122:153	the only alkaline polysaccharose available in nature	122:173	Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility.
34229786	1	41	theme	drug	218:221	arg1	delivery					223:230	drug delivery	218:230	drug delivery owing to its excellent biodegradability and biocompatibility	218:291	Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility.
34229786	6	42	with	membranes	938:946	arg1	ratio					957:961	the ratio	953:961	the ratio of 1:0.13:0.67	953:976	The morphology of the optimum membranes with the ratio of 1:0.13:0.67 was smoother with less beads and uniform fiber diameter.
34229786	1	43	theme	alkaline	131:138	arg1	Chitosan					107:114	Chitosan	107:114	Chitosan (CS)	107:119	Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility.
34229786	1	43	theme	alkaline	131:138	arg1	polysaccharose					140:153	the only alkaline polysaccharose	122:153	the only alkaline polysaccharose available in nature	122:173	Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility.
34229786	0	44	theme	Drug	93:96	arg1	Carrier					98:104	a Novel and Promising Drug Carrier	71:104	a Novel and Promising Drug Carrier	71:104	Polyamide/Chitosan/Tetraethyl Orthosilicate Electrospun Nanofibers for a Novel and Promising Drug Carrier.
34229786	1	45	theme	available	155:163	arg1	Chitosan					107:114	Chitosan	107:114	Chitosan (CS)	107:119	Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility.
34229786	1	45	theme	available	155:163	arg1	polysaccharose					140:153	the only alkaline polysaccharose	122:153	the only alkaline polysaccharose available in nature	122:173	Chitosan (CS), the only alkaline polysaccharose available in nature, has always been a promising candidate for drug delivery owing to its excellent biodegradability and biocompatibility.
34229786	3	46	theme	polyamide/chitosan/tetraethyl	520:548	arg1	carriers					633:640	drug carriers	628:640	drug carriers in this study	628:654	To solve this problem and extend the applications of CS, polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers were successfully prepared as drug carriers in this study via electrospinning.
34229786	3	46	theme	polyamide/chitosan/tetraethyl	520:548	arg1	nanofibers					587:596	polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers	520:596	polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers	520:596	To solve this problem and extend the applications of CS, polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers were successfully prepared as drug carriers in this study via electrospinning.
34229786	0	47	theme	Promising	83:91	arg1	Carrier					98:104	a Novel and Promising Drug Carrier	71:104	a Novel and Promising Drug Carrier	71:104	Polyamide/Chitosan/Tetraethyl Orthosilicate Electrospun Nanofibers for a Novel and Promising Drug Carrier.
34229786	5	48	theme	scanning	872:879	arg1	SEM					902:904	SEM	902:904	SEM	902:904	As the content of each was increased, the beads among the membranes increased initially and then decreased, determined by scanning electron microscopy (SEM).
34229786	5	48	theme	scanning	872:879	arg1	microscopy					890:899	scanning electron microscopy	872:899	scanning electron microscopy (SEM)	872:905	As the content of each was increased, the beads among the membranes increased initially and then decreased, determined by scanning electron microscopy (SEM).
34229786	3	49	theme	orthosilicate	550:562	arg1	carriers					633:640	drug carriers	628:640	drug carriers in this study	628:654	To solve this problem and extend the applications of CS, polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers were successfully prepared as drug carriers in this study via electrospinning.
34229786	3	49	theme	orthosilicate	550:562	arg1	nanofibers					587:596	polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers	520:596	polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers	520:596	To solve this problem and extend the applications of CS, polyamide/chitosan/tetraethyl orthosilicate (PA/CS/TEOS) composite nanofibers were successfully prepared as drug carriers in this study via electrospinning.
34019926	0	0	theme	alcohol	117:123	arg1	composites					125:134	bioactive glass/chitosan/polyvinyl alcohol composites	82:134	bioactive glass/chitosan/polyvinyl alcohol composites	82:134	Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites.
34019926	9	1	theme	developed	1082:1090	arg1	vehicles					1155:1162	drug-delivery vehicles	1141:1162	drug-delivery vehicles due to their efficiency and sustained drug release capacity	1141:1222	The developed nano-fiber composites can be potentially used as drug-delivery vehicles due to their efficiency and sustained drug release capacity.
34019926	9	1	theme	developed	1082:1090	arg1	composites					1103:1112	The developed nano-fiber composites	1078:1112	The developed nano-fiber composites	1078:1112	The developed nano-fiber composites can be potentially used as drug-delivery vehicles due to their efficiency and sustained drug release capacity.
34019926	9	2	theme	due	1164:1166	arg1	vehicles					1155:1162	drug-delivery vehicles	1141:1162	drug-delivery vehicles due to their efficiency and sustained drug release capacity	1141:1222	The developed nano-fiber composites can be potentially used as drug-delivery vehicles due to their efficiency and sustained drug release capacity.
34019926	9	2	theme	due	1164:1166	arg1	composites					1103:1112	The developed nano-fiber composites	1078:1112	The developed nano-fiber composites	1078:1112	The developed nano-fiber composites can be potentially used as drug-delivery vehicles due to their efficiency and sustained drug release capacity.
34019926	4	3	with	uniform	489:495	arg1	diameter					527:534	a diameter	525:534	a diameter of 20-125 nm	525:547	of BG were uniform, dense and defect-free with a diameter of 20-125 nm.
34019926	0	4	theme	glass/chitosan/polyvinyl	92:115	arg1	composites					125:134	bioactive glass/chitosan/polyvinyl alcohol composites	82:134	bioactive glass/chitosan/polyvinyl alcohol composites	82:134	Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites.
34019926	9	5	theme	release	1207:1213	arg1	capacity					1215:1222	sustained drug release capacity	1192:1222	sustained drug release capacity	1192:1222	The developed nano-fiber composites can be potentially used as drug-delivery vehicles due to their efficiency and sustained drug release capacity.
34019926	8	6	theme	release	1025:1031	arg1	efficiency					1033:1042	the drug release efficiency	1016:1042	the drug release efficiency	1016:1042	They also enhanced the drug release efficiency by releasing 93 ± 4% of the drug.
34019926	2	7	theme	glass	394:398	arg1	ratios					369:374	different weight ratios	352:374	different weight ratios of nano-bioactive glass (BG)	352:403	Herein, novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning.
34019926	7	8	theme	release	941:947	arg1	profile					949:955	the drug release profile	932:955	the drug release profile relative to their BG-free counterparts	932:994	BG-incorporated nano-fibers markedly retarded the drug release profile relative to their BG-free counterparts.
34019926	5	9	theme	in-vitro	661:668	arg1	release					675:681	the in-vitro drug release	657:681	the in-vitro drug release	657:681	The model osteoporotic drug (Risedronate sodium) was blended with the electrospinning forming solution and the in-vitro drug release was further studied.
34019926	5	10	theme	drug	670:673	arg1	release					675:681	the in-vitro drug release	657:681	the in-vitro drug release	657:681	The model osteoporotic drug (Risedronate sodium) was blended with the electrospinning forming solution and the in-vitro drug release was further studied.
34019926	6	11	theme	diffusion	865:873	arg1	mechanism					875:883	a two-stage intra-particle diffusion mechanism	838:883	a two-stage intra-particle diffusion mechanism	838:883	About 30% of the drug was released after only 30 min and the release pattern was sustained over 96 h. Drug release took place through a two-stage intra-particle diffusion mechanism.
34019926	8	12	theme	±	1060:1060	arg1	drug					1072:1075	the drug	1068:1075	the drug	1068:1075	They also enhanced the drug release efficiency by releasing 93 ± 4% of the drug.
34019926	8	12	theme	±	1060:1060	arg1	%					1063:1063	93 ± 4%	1057:1063	93 ± 4% of the drug	1057:1075	They also enhanced the drug release efficiency by releasing 93 ± 4% of the drug.
34019926	7	13	theme	relative	957:964	arg1	profile					949:955	the drug release profile	932:955	the drug release profile relative to their BG-free counterparts	932:994	BG-incorporated nano-fibers markedly retarded the drug release profile relative to their BG-free counterparts.
34019926	2	14	theme	chitosan	327:334	arg1	blend					290:294	a blend	288:294	a blend of polyvinyl alcohol (PVA) and chitosan (CS)	288:339	Herein, novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning.
34019926	6	15	theme	intra-particle	850:863	arg1	mechanism					875:883	a two-stage intra-particle diffusion mechanism	838:883	a two-stage intra-particle diffusion mechanism	838:883	About 30% of the drug was released after only 30 min and the release pattern was sustained over 96 h. Drug release took place through a two-stage intra-particle diffusion mechanism.
34019926	5	16	theme	electrospinning	620:634	arg1	solution					644:651	the electrospinning forming solution	616:651	the electrospinning forming solution	616:651	The model osteoporotic drug (Risedronate sodium) was blended with the electrospinning forming solution and the in-vitro drug release was further studied.
34019926	6	17	theme	release	765:771	arg1	pattern					773:779	the release pattern	761:779	the release pattern	761:779	About 30% of the drug was released after only 30 min and the release pattern was sustained over 96 h. Drug release took place through a two-stage intra-particle diffusion mechanism.
34019926	0	18	theme	drug	10:13	arg1	vehicles					24:31	Efficient drug delivery vehicles	0:31	Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites	0:134	Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites.
34019926	6	19	theme	two-stage	840:848	arg1	mechanism					875:883	a two-stage intra-particle diffusion mechanism	838:883	a two-stage intra-particle diffusion mechanism	838:883	About 30% of the drug was released after only 30 min and the release pattern was sustained over 96 h. Drug release took place through a two-stage intra-particle diffusion mechanism.
34019926	5	20	theme	forming	636:642	arg1	solution					644:651	the electrospinning forming solution	616:651	the electrospinning forming solution	616:651	The model osteoporotic drug (Risedronate sodium) was blended with the electrospinning forming solution and the in-vitro drug release was further studied.
34019926	1	21	from	potential	180:188	arg1	applications					225:236	biomedical and biotechnological applications	193:236	biomedical and biotechnological applications	193:236	Nano-fiber composites have shown promising potential in biomedical and biotechnological applications.
34019926	2	22	theme	different	352:360	arg1	ratios					369:374	different weight ratios	352:374	different weight ratios of nano-bioactive glass (BG)	352:403	Herein, novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning.
34019926	0	23	theme	Efficient	0:8	arg1	vehicles					24:31	Efficient drug delivery vehicles	0:31	Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites	0:134	Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites.
34019926	6	24	dep	h.	803:804	arg1	took					819:822	took	819:822	took place through a two-stage intra-particle diffusion mechanism	819:883	About 30% of the drug was released after only 30 min and the release pattern was sustained over 96 h. Drug release took place through a two-stage intra-particle diffusion mechanism.
34019926	5	25	theme	Risedronate	579:589	arg1	drug					573:576	The model osteoporotic drug	550:576	The model osteoporotic drug (Risedronate sodium)	550:597	The model osteoporotic drug (Risedronate sodium) was blended with the electrospinning forming solution and the in-vitro drug release was further studied.
34019926	5	25	theme	Risedronate	579:589	arg1	sodium					591:596	Risedronate sodium	579:596	Risedronate sodium	579:596	The model osteoporotic drug (Risedronate sodium) was blended with the electrospinning forming solution and the in-vitro drug release was further studied.
34019926	8	26	theme	drug	1020:1023	arg1	efficiency					1033:1042	the drug release efficiency	1016:1042	the drug release efficiency	1016:1042	They also enhanced the drug release efficiency by releasing 93 ± 4% of the drug.
34019926	1	27	theme	Nano-fiber	137:146	arg1	composites					148:157	Nano-fiber composites	137:157	Nano-fiber composites	137:157	Nano-fiber composites have shown promising potential in biomedical and biotechnological applications.
34019926	3	28	dep	%	467:467	arg1	wt					473:474	wt	473:474	wt	473:474	Nano-fibers incorporating 10% (by wt.)
34019926	0	29	theme	delivery	15:22	arg1	vehicles					24:31	Efficient drug delivery vehicles	0:31	Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites	0:134	Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites.
34019926	1	30	theme	biotechnological	208:223	arg1	applications					225:236	biomedical and biotechnological applications	193:236	biomedical and biotechnological applications	193:236	Nano-fiber composites have shown promising potential in biomedical and biotechnological applications.
34019926	9	31	theme	nano-fiber	1092:1101	arg1	vehicles					1155:1162	drug-delivery vehicles	1141:1162	drug-delivery vehicles due to their efficiency and sustained drug release capacity	1141:1222	The developed nano-fiber composites can be potentially used as drug-delivery vehicles due to their efficiency and sustained drug release capacity.
34019926	9	31	theme	nano-fiber	1092:1101	arg1	composites					1103:1112	The developed nano-fiber composites	1078:1112	The developed nano-fiber composites	1078:1112	The developed nano-fiber composites can be potentially used as drug-delivery vehicles due to their efficiency and sustained drug release capacity.
34019926	2	32	theme	polyvinyl	299:307	arg1	PVA					318:320	PVA	318:320	PVA	318:320	Herein, novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning.
34019926	2	32	theme	polyvinyl	299:307	arg1	alcohol					309:315	polyvinyl alcohol	299:315	polyvinyl alcohol (PVA)	299:321	Herein, novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning.
34019926	8	33	theme	drug	1072:1075	arg1	drug					1072:1075	the drug	1068:1075	the drug	1068:1075	They also enhanced the drug release efficiency by releasing 93 ± 4% of the drug.
34019926	8	33	theme	drug	1072:1075	arg1	%					1063:1063	93 ± 4%	1057:1063	93 ± 4% of the drug	1057:1075	They also enhanced the drug release efficiency by releasing 93 ± 4% of the drug.
34019926	4	34	theme	BG	481:482	arg1	uniform					489:495	uniform	489:495	uniform	489:495	of BG were uniform, dense and defect-free with a diameter of 20-125 nm.
34019926	9	35	theme	drug-delivery	1141:1153	arg1	vehicles					1155:1162	drug-delivery vehicles	1141:1162	drug-delivery vehicles due to their efficiency and sustained drug release capacity	1141:1222	The developed nano-fiber composites can be potentially used as drug-delivery vehicles due to their efficiency and sustained drug release capacity.
34019926	9	35	theme	drug-delivery	1141:1153	arg1	composites					1103:1112	The developed nano-fiber composites	1078:1112	The developed nano-fiber composites	1078:1112	The developed nano-fiber composites can be potentially used as drug-delivery vehicles due to their efficiency and sustained drug release capacity.
34019926	0	36	theme	nano-fibers	59:69	arg1	vehicles					24:31	Efficient drug delivery vehicles	0:31	Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites	0:134	Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites.
34019926	2	37	theme	nano-bioactive	379:392	arg1	BG					401:402	BG	401:402	BG	401:402	Herein, novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning.
34019926	2	37	theme	nano-bioactive	379:392	arg1	glass					394:398	nano-bioactive glass	379:398	nano-bioactive glass (BG)	379:403	Herein, novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning.
34019926	0	38	theme	benign	52:57	arg1	nano-fibers					59:69	environmentally benign nano-fibers	36:69	environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites	36:134	Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites.
34019926	4	39	theme	nm	546:547	arg1	diameter					527:534	a diameter	525:534	a diameter of 20-125 nm	525:547	of BG were uniform, dense and defect-free with a diameter of 20-125 nm.
34019926	7	40	theme	drug	936:939	arg1	profile					949:955	the drug release profile	932:955	the drug release profile relative to their BG-free counterparts	932:994	BG-incorporated nano-fibers markedly retarded the drug release profile relative to their BG-free counterparts.
34019926	5	41	theme	model	554:558	arg1	drug					573:576	The model osteoporotic drug	550:576	The model osteoporotic drug (Risedronate sodium)	550:597	The model osteoporotic drug (Risedronate sodium) was blended with the electrospinning forming solution and the in-vitro drug release was further studied.
34019926	5	41	theme	model	554:558	arg1	sodium					591:596	Risedronate sodium	579:596	Risedronate sodium	579:596	The model osteoporotic drug (Risedronate sodium) was blended with the electrospinning forming solution and the in-vitro drug release was further studied.
34019926	6	42	theme	Drug	806:809	arg1	release					811:817	Drug release	806:817	Drug release	806:817	About 30% of the drug was released after only 30 min and the release pattern was sustained over 96 h. Drug release took place through a two-stage intra-particle diffusion mechanism.
34019926	9	43	used	used	1133:1136	arg2	composites					1103:1112	The developed nano-fiber composites	1078:1112	The developed nano-fiber composites	1078:1112	The developed nano-fiber composites can be potentially used as drug-delivery vehicles due to their efficiency and sustained drug release capacity.
34019926	9	43	used	used	1133:1136	arg2	vehicles					1155:1162	drug-delivery vehicles	1141:1162	drug-delivery vehicles due to their efficiency and sustained drug release capacity	1141:1222	The developed nano-fiber composites can be potentially used as drug-delivery vehicles due to their efficiency and sustained drug release capacity.
34019926	5	44	theme	osteoporotic	560:571	arg1	drug					573:576	The model osteoporotic drug	550:576	The model osteoporotic drug (Risedronate sodium)	550:597	The model osteoporotic drug (Risedronate sodium) was blended with the electrospinning forming solution and the in-vitro drug release was further studied.
34019926	5	44	theme	osteoporotic	560:571	arg1	sodium					591:596	Risedronate sodium	579:596	Risedronate sodium	579:596	The model osteoporotic drug (Risedronate sodium) was blended with the electrospinning forming solution and the in-vitro drug release was further studied.
34019926	1	45	theme	promising	170:178	arg1	potential					180:188	promising potential	170:188	promising potential in biomedical and biotechnological applications	170:236	Nano-fiber composites have shown promising potential in biomedical and biotechnological applications.
34019926	2	46	theme	nano-fiber	253:262	arg1	composites					264:273	novel nano-fiber composites	247:273	novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG)	247:403	Herein, novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning.
34019926	2	47	theme	weight	362:367	arg1	ratios					369:374	different weight ratios	352:374	different weight ratios of nano-bioactive glass (BG)	352:403	Herein, novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning.
34019926	0	48	theme	bioactive	82:90	arg1	composites					125:134	bioactive glass/chitosan/polyvinyl alcohol composites	82:134	bioactive glass/chitosan/polyvinyl alcohol composites	82:134	Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites.
34019926	2	49	theme	novel	247:251	arg1	composites					264:273	novel nano-fiber composites	247:273	novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG)	247:403	Herein, novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning.
34019926	6	50	theme	drug	721:724	arg1	drug					721:724	the drug	717:724	the drug	717:724	About 30% of the drug was released after only 30 min and the release pattern was sustained over 96 h. Drug release took place through a two-stage intra-particle diffusion mechanism.
34019926	6	50	theme	drug	721:724	arg1	%					712:712	About 30%	704:712	About 30% of the drug	704:724	About 30% of the drug was released after only 30 min and the release pattern was sustained over 96 h. Drug release took place through a two-stage intra-particle diffusion mechanism.
34019926	7	51	theme	BG-incorporated	886:900	arg1	nano-fibers					902:912	BG-incorporated nano-fibers	886:912	BG-incorporated nano-fibers	886:912	BG-incorporated nano-fibers markedly retarded the drug release profile relative to their BG-free counterparts.
34019926	9	52	theme	drug	1202:1205	arg1	capacity					1215:1222	sustained drug release capacity	1192:1222	sustained drug release capacity	1192:1222	The developed nano-fiber composites can be potentially used as drug-delivery vehicles due to their efficiency and sustained drug release capacity.
34019926	9	53	theme	sustained	1192:1200	arg1	capacity					1215:1222	sustained drug release capacity	1192:1222	sustained drug release capacity	1192:1222	The developed nano-fiber composites can be potentially used as drug-delivery vehicles due to their efficiency and sustained drug release capacity.
34019926	2	54	theme	alcohol	309:315	arg1	blend					290:294	a blend	288:294	a blend of polyvinyl alcohol (PVA) and chitosan (CS)	288:339	Herein, novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning.
34019926	7	55	theme	BG-free	975:981	arg1	counterparts					983:994	their BG-free counterparts	969:994	their BG-free counterparts	969:994	BG-incorporated nano-fibers markedly retarded the drug release profile relative to their BG-free counterparts.
34019926	1	56	theme	biomedical	193:202	arg1	applications					225:236	biomedical and biotechnological applications	193:236	biomedical and biotechnological applications	193:236	Nano-fiber composites have shown promising potential in biomedical and biotechnological applications.
34052753	0	0	theme	human	89:93	arg1	glycosaminoglycans					95:112	human glycosaminoglycans	89:112	human glycosaminoglycans	89:112	Analytical performance of a standardized kit for mass spectrometry-based measurements of human glycosaminoglycans.
34052753	3	1	dep	method	620:625	arg1	measure					645:651	measure	645:651	to simultaneously measure multiple GAGs	627:665	However, owing to the analytical complexity associated with the quantification of GAG concentration and structural composition, a standardized method to simultaneously measure multiple GAGs is missing.
34052753	8	2	theme	free	1549:1552	arg1	disaccharides					1558:1570	free GAG disaccharides	1549:1570	free GAG disaccharides allowing for comparability of measurements and enabling translational research	1549:1649	In conclusion, these results indicated that the UHPLC-MS/MS kit was standardized for the simultaneous measurement of free GAG disaccharides allowing for comparability of measurements and enabling translational research.
34052753	6	3	theme	kit	1193:1195	arg1	acceptable					1201:1210	acceptable	1201:1210	acceptable	1201:1210	In native human samples, here using urine as a reference matrix, the analytical performance of the kit was acceptable for the quantification of CS disaccharides.
34052753	6	3	theme	kit	1193:1195	arg1	performance					1174:1184	the analytical performance	1159:1184	the analytical performance of the kit	1159:1195	In native human samples, here using urine as a reference matrix, the analytical performance of the kit was acceptable for the quantification of CS disaccharides.
34052753	7	4	theme	inter-laboratory	1267:1282	arg1	tests					1284:1288	Intra- and inter-laboratory tests	1256:1288	Intra- and inter-laboratory tests performed in an external laboratory	1256:1324	Intra- and inter-laboratory tests performed in an external laboratory demonstrated robust reproducibility of GAG measurements showing that the kit was acceptably standardized.
34052753	8	5	theme	translational	1628:1640	arg1	research					1642:1649	translational research	1628:1649	translational research	1628:1649	In conclusion, these results indicated that the UHPLC-MS/MS kit was standardized for the simultaneous measurement of free GAG disaccharides allowing for comparability of measurements and enabling translational research.
34052753	8	6	theme	simultaneous	1521:1532	arg1	measurement					1534:1544	the simultaneous measurement	1517:1544	the simultaneous measurement of free GAG disaccharides allowing for comparability of measurements and enabling translational research	1517:1649	In conclusion, these results indicated that the UHPLC-MS/MS kit was standardized for the simultaneous measurement of free GAG disaccharides allowing for comparability of measurements and enabling translational research.
34052753	3	7	theme	composition	592:602	arg1	quantification					541:554	the quantification	537:554	the quantification of GAG concentration and structural composition	537:602	However, owing to the analytical complexity associated with the quantification of GAG concentration and structural composition, a standardized method to simultaneously measure multiple GAGs is missing.
34052753	4	8	theme	tandem	828:833	arg1	spectrometry					840:851	triple-quadrupole tandem mass spectrometry	810:851	triple-quadrupole tandem mass spectrometry	810:851	In this study, we sought to characterize the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides.
34052753	0	9	theme	glycosaminoglycans	95:112	arg1	measurements					73:84	mass spectrometry-based measurements	49:84	mass spectrometry-based measurements of human glycosaminoglycans	49:112	Analytical performance of a standardized kit for mass spectrometry-based measurements of human glycosaminoglycans.
34052753	6	10	theme	disaccharides	1241:1253	arg1	quantification					1220:1233	the quantification	1216:1233	the quantification of CS disaccharides	1216:1253	In native human samples, here using urine as a reference matrix, the analytical performance of the kit was acceptable for the quantification of CS disaccharides.
34052753	7	11	theme	GAG	1365:1367	arg1	measurements					1369:1380	GAG measurements	1365:1380	GAG measurements	1365:1380	Intra- and inter-laboratory tests performed in an external laboratory demonstrated robust reproducibility of GAG measurements showing that the kit was acceptably standardized.
34052753	7	12	theme	Intra-	1256:1261	arg1	tests					1284:1288	Intra- and inter-laboratory tests	1256:1288	Intra- and inter-laboratory tests performed in an external laboratory	1256:1324	Intra- and inter-laboratory tests performed in an external laboratory demonstrated robust reproducibility of GAG measurements showing that the kit was acceptably standardized.
34052753	4	13	theme	liquid	775:780	arg1	chromatography					782:795	a ultra-high-performance liquid chromatography	750:795	a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry	750:851	In this study, we sought to characterize the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides.
34052753	4	14	theme	disaccharides	915:927	arg1	quantification					885:898	the quantification	881:898	the quantification of 17 free GAG disaccharides	881:927	In this study, we sought to characterize the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides.
34052753	3	15	theme	analytical	499:508	arg1	complexity					510:519	the analytical complexity	495:519	the analytical complexity associated with the quantification of GAG concentration and structural composition	495:602	However, owing to the analytical complexity associated with the quantification of GAG concentration and structural composition, a standardized method to simultaneously measure multiple GAGs is missing.
34052753	5	16	theme	absolute	1049:1056	arg1	quantification					1058:1071	the absolute quantification	1045:1071	the absolute quantification of 15 disaccharides	1045:1091	The kit showed acceptable linearity, selectivity and specificity, accuracy and precision, and analyte stability in the absolute quantification of 15 disaccharides.
34052753	8	17	theme	UHPLC-MS/MS	1480:1490	arg1	kit					1492:1494	the UHPLC-MS/MS kit	1476:1494	the UHPLC-MS/MS kit	1476:1494	In conclusion, these results indicated that the UHPLC-MS/MS kit was standardized for the simultaneous measurement of free GAG disaccharides allowing for comparability of measurements and enabling translational research.
34052753	4	18	theme	GAG	911:913	arg1	disaccharides					915:927	17 free GAG disaccharides	903:927	17 free GAG disaccharides	903:927	In this study, we sought to characterize the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides.
34052753	3	19	theme	structural	581:590	arg1	composition					592:602	structural composition	581:602	structural composition	581:602	However, owing to the analytical complexity associated with the quantification of GAG concentration and structural composition, a standardized method to simultaneously measure multiple GAGs is missing.
34052753	6	20	theme	reference	1141:1149	arg1	urine					1130:1134	urine	1130:1134	urine	1130:1134	In native human samples, here using urine as a reference matrix, the analytical performance of the kit was acceptable for the quantification of CS disaccharides.
34052753	6	20	theme	reference	1141:1149	arg1	matrix					1151:1156	a reference matrix	1139:1156	a reference matrix	1139:1156	In native human samples, here using urine as a reference matrix, the analytical performance of the kit was acceptable for the quantification of CS disaccharides.
34052753	4	21	theme	triple-quadrupole	810:826	arg1	spectrometry					840:851	triple-quadrupole tandem mass spectrometry	810:851	triple-quadrupole tandem mass spectrometry	810:851	In this study, we sought to characterize the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides.
34052753	5	22	theme	acceptable	945:954	arg1	linearity					956:964	acceptable linearity	945:964	acceptable linearity	945:964	The kit showed acceptable linearity, selectivity and specificity, accuracy and precision, and analyte stability in the absolute quantification of 15 disaccharides.
34052753	0	23	theme	Analytical	0:9	arg1	performance					11:21	Analytical performance	0:21	Analytical performance of a	0:26	Analytical performance of a standardized kit for mass spectrometry-based measurements of human glycosaminoglycans.
34052753	1	24	theme	viral	300:304	arg1	infections					306:315	viral infections	300:315	viral infections	300:315	Glycosaminoglycans (GAGs) are long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections, thereby serving as potential biomarkers.
34052753	4	25	dep	-based	866:871	arg1	chromatography					782:795	a ultra-high-performance liquid chromatography	750:795	a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry	750:851	In this study, we sought to characterize the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides.
34052753	0	26	theme	a	26:26	arg1	performance					11:21	Analytical performance	0:21	Analytical performance of a	0:26	Analytical performance of a standardized kit for mass spectrometry-based measurements of human glycosaminoglycans.
34052753	8	27	theme	disaccharides	1558:1570	arg1	measurement					1534:1544	the simultaneous measurement	1517:1544	the simultaneous measurement of free GAG disaccharides allowing for comparability of measurements and enabling translational research	1517:1649	In conclusion, these results indicated that the UHPLC-MS/MS kit was standardized for the simultaneous measurement of free GAG disaccharides allowing for comparability of measurements and enabling translational research.
34052753	4	28	theme	mass	835:838	arg1	spectrometry					840:851	triple-quadrupole tandem mass spectrometry	810:851	triple-quadrupole tandem mass spectrometry	810:851	In this study, we sought to characterize the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides.
34052753	2	29	theme	GAG	459:461	arg1	measurements					463:474	standardized GAG measurements	446:474	standardized GAG measurements	446:474	A successful clinical translation of GAGs as biomarkers depends on the availability of standardized GAG measurements.
34052753	2	30	theme	measurements	463:474	arg1	availability					430:441	the availability	426:441	the availability of standardized GAG measurements	426:474	A successful clinical translation of GAGs as biomarkers depends on the availability of standardized GAG measurements.
34052753	6	31	theme	CS	1238:1239	arg1	disaccharides					1241:1253	CS disaccharides	1238:1253	CS disaccharides	1238:1253	In native human samples, here using urine as a reference matrix, the analytical performance of the kit was acceptable for the quantification of CS disaccharides.
34052753	8	32	theme	GAG	1554:1556	arg1	disaccharides					1558:1570	free GAG disaccharides	1549:1570	free GAG disaccharides allowing for comparability of measurements and enabling translational research	1549:1649	In conclusion, these results indicated that the UHPLC-MS/MS kit was standardized for the simultaneous measurement of free GAG disaccharides allowing for comparability of measurements and enabling translational research.
34052753	3	33	theme	standardized	607:618	arg1	missing					670:676	missing	670:676	missing	670:676	However, owing to the analytical complexity associated with the quantification of GAG concentration and structural composition, a standardized method to simultaneously measure multiple GAGs is missing.
34052753	3	33	theme	standardized	607:618	arg1	method					620:625	a standardized method	605:625	a standardized method to simultaneously measure multiple GAGs	605:665	However, owing to the analytical complexity associated with the quantification of GAG concentration and structural composition, a standardized method to simultaneously measure multiple GAGs is missing.
34052753	2	34	theme	standardized	446:457	arg1	measurements					463:474	standardized GAG measurements	446:474	standardized GAG measurements	446:474	A successful clinical translation of GAGs as biomarkers depends on the availability of standardized GAG measurements.
34052753	4	35	theme	ultra-high-performance	752:773	arg1	chromatography					782:795	a ultra-high-performance liquid chromatography	750:795	a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry	750:851	In this study, we sought to characterize the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides.
34052753	7	36	theme	robust	1339:1344	arg1	reproducibility					1346:1360	robust reproducibility	1339:1360	robust reproducibility of GAG measurements	1339:1380	Intra- and inter-laboratory tests performed in an external laboratory demonstrated robust reproducibility of GAG measurements showing that the kit was acceptably standardized.
34052753	3	37	theme	multiple	653:660	arg1	GAGs					662:665	multiple GAGs	653:665	multiple GAGs	653:665	However, owing to the analytical complexity associated with the quantification of GAG concentration and structural composition, a standardized method to simultaneously measure multiple GAGs is missing.
34052753	6	38	theme	native	1097:1102	arg1	samples					1110:1116	native human samples	1097:1116	native human samples	1097:1116	In native human samples, here using urine as a reference matrix, the analytical performance of the kit was acceptable for the quantification of CS disaccharides.
34052753	8	39	dep	disaccharides	1558:1570	arg1	allowing					1572:1579	allowing	1572:1579	allowing for comparability of measurements	1572:1613	In conclusion, these results indicated that the UHPLC-MS/MS kit was standardized for the simultaneous measurement of free GAG disaccharides allowing for comparability of measurements and enabling translational research.
34052753	8	39	dep	disaccharides	1558:1570	arg1	enabling					1619:1626	enabling	1619:1626	enabling translational research	1619:1649	In conclusion, these results indicated that the UHPLC-MS/MS kit was standardized for the simultaneous measurement of free GAG disaccharides allowing for comparability of measurements and enabling translational research.
34052753	1	40	attach	linked	206:211	arg1	development					224:234	disease development	216:234	disease development	216:234	Glycosaminoglycans (GAGs) are long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections, thereby serving as potential biomarkers.
34052753	1	40	attach	linked	206:211	arg2	processes					196:204	processes	196:204	processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections	196:315	Glycosaminoglycans (GAGs) are long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections, thereby serving as potential biomarkers.
34052753	4	41	theme	free	906:909	arg1	disaccharides					915:927	17 free GAG disaccharides	903:927	17 free GAG disaccharides	903:927	In this study, we sought to characterize the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides.
34052753	2	42	theme	clinical	372:379	arg1	translation					381:391	A successful clinical translation	359:391	A successful clinical translation of GAGs as biomarkers	359:413	A successful clinical translation of GAGs as biomarkers depends on the availability of standardized GAG measurements.
34052753	2	43	theme	GAGs	396:399	arg1	translation					381:391	A successful clinical translation	359:391	A successful clinical translation of GAGs as biomarkers	359:413	A successful clinical translation of GAGs as biomarkers depends on the availability of standardized GAG measurements.
34052753	1	44	theme	potential	337:345	arg1	biomarkers					347:356	potential biomarkers	337:356	potential biomarkers	337:356	Glycosaminoglycans (GAGs) are long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections, thereby serving as potential biomarkers.
34052753	1	45	theme	sulfated	157:164	arg1	Glycosaminoglycans					115:132	Glycosaminoglycans	115:132	Glycosaminoglycans (GAGs)	115:139	Glycosaminoglycans (GAGs) are long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections, thereby serving as potential biomarkers.
34052753	1	45	theme	sulfated	157:164	arg1	polysaccharides					166:180	long linear sulfated polysaccharides	145:180	long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections	145:315	Glycosaminoglycans (GAGs) are long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections, thereby serving as potential biomarkers.
34052753	7	46	theme	measurements	1369:1380	arg1	reproducibility					1346:1360	robust reproducibility	1339:1360	robust reproducibility of GAG measurements	1339:1380	Intra- and inter-laboratory tests performed in an external laboratory demonstrated robust reproducibility of GAG measurements showing that the kit was acceptably standardized.
34052753	2	47	theme	successful	361:370	arg1	translation					381:391	A successful clinical translation	359:391	A successful clinical translation of GAGs as biomarkers	359:413	A successful clinical translation of GAGs as biomarkers depends on the availability of standardized GAG measurements.
34052753	1	48	theme	linear	150:155	arg1	Glycosaminoglycans					115:132	Glycosaminoglycans	115:132	Glycosaminoglycans (GAGs)	115:139	Glycosaminoglycans (GAGs) are long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections, thereby serving as potential biomarkers.
34052753	1	48	theme	linear	150:155	arg1	polysaccharides					166:180	long linear sulfated polysaccharides	145:180	long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections	145:315	Glycosaminoglycans (GAGs) are long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections, thereby serving as potential biomarkers.
34052753	4	49	theme	kit	873:875	arg1	performance					735:745	the analytical performance	720:745	the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides	720:927	In this study, we sought to characterize the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides.
34052753	4	50	theme	analytical	724:733	arg1	performance					735:745	the analytical performance	720:745	the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides	720:927	In this study, we sought to characterize the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides.
34052753	5	51	theme	analyte	1024:1030	arg1	stability					1032:1040	analyte stability	1024:1040	analyte stability	1024:1040	The kit showed acceptable linearity, selectivity and specificity, accuracy and precision, and analyte stability in the absolute quantification of 15 disaccharides.
34052753	8	52	theme	measurements	1602:1613	arg1	comparability					1585:1597	comparability	1585:1597	comparability of measurements	1585:1613	In conclusion, these results indicated that the UHPLC-MS/MS kit was standardized for the simultaneous measurement of free GAG disaccharides allowing for comparability of measurements and enabling translational research.
34052753	4	53	theme	-based	866:871	arg1	kit					873:875	a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit	750:875	a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit	750:875	In this study, we sought to characterize the analytical performance of a ultra-high-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-MS/MS)-based kit for the quantification of 17 free GAG disaccharides.
34052753	1	54	theme	long	145:148	arg1	Glycosaminoglycans					115:132	Glycosaminoglycans	115:132	Glycosaminoglycans (GAGs)	115:139	Glycosaminoglycans (GAGs) are long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections, thereby serving as potential biomarkers.
34052753	1	54	theme	long	145:148	arg1	polysaccharides					166:180	long linear sulfated polysaccharides	145:180	long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections	145:315	Glycosaminoglycans (GAGs) are long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections, thereby serving as potential biomarkers.
34052753	6	55	theme	human	1104:1108	arg1	samples					1110:1116	native human samples	1097:1116	native human samples	1097:1116	In native human samples, here using urine as a reference matrix, the analytical performance of the kit was acceptable for the quantification of CS disaccharides.
34052753	6	56	theme	analytical	1163:1172	arg1	acceptable					1201:1210	acceptable	1201:1210	acceptable	1201:1210	In native human samples, here using urine as a reference matrix, the analytical performance of the kit was acceptable for the quantification of CS disaccharides.
34052753	6	56	theme	analytical	1163:1172	arg1	performance					1174:1184	the analytical performance	1159:1184	the analytical performance of the kit	1159:1195	In native human samples, here using urine as a reference matrix, the analytical performance of the kit was acceptable for the quantification of CS disaccharides.
34052753	5	57	theme	disaccharides	1079:1091	arg1	quantification					1058:1071	the absolute quantification	1045:1071	the absolute quantification of 15 disaccharides	1045:1091	The kit showed acceptable linearity, selectivity and specificity, accuracy and precision, and analyte stability in the absolute quantification of 15 disaccharides.
34052753	1	58	theme	disease	216:222	arg1	development					224:234	disease development	216:234	disease development	216:234	Glycosaminoglycans (GAGs) are long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections, thereby serving as potential biomarkers.
34052753	3	59	theme	GAG	559:561	arg1	concentration					563:575	GAG concentration	559:575	GAG concentration	559:575	However, owing to the analytical complexity associated with the quantification of GAG concentration and structural composition, a standardized method to simultaneously measure multiple GAGs is missing.
34052753	7	60	theme	external	1306:1313	arg1	laboratory					1315:1324	an external laboratory	1303:1324	an external laboratory	1303:1324	Intra- and inter-laboratory tests performed in an external laboratory demonstrated robust reproducibility of GAG measurements showing that the kit was acceptably standardized.
34052753	1	61	theme	respiratory	267:277	arg1	failure					279:285	respiratory failure	267:285	respiratory failure	267:285	Glycosaminoglycans (GAGs) are long linear sulfated polysaccharides implicated in processes linked to disease development such as mucopolysaccharidosis, respiratory failure, cancer, and viral infections, thereby serving as potential biomarkers.
34052753	0	62	theme	spectrometry-based	54:71	arg1	measurements					73:84	mass spectrometry-based measurements	49:84	mass spectrometry-based measurements of human glycosaminoglycans	49:112	Analytical performance of a standardized kit for mass spectrometry-based measurements of human glycosaminoglycans.
34052753	3	63	theme	concentration	563:575	arg1	quantification					541:554	the quantification	537:554	the quantification of GAG concentration and structural composition	537:602	However, owing to the analytical complexity associated with the quantification of GAG concentration and structural composition, a standardized method to simultaneously measure multiple GAGs is missing.
34126151	0	0	theme	mechanical	111:120	arg1	training					122:129	triple-network and mechanical training	92:129	triple-network and mechanical training	92:129	Ultra-strong hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel by combination of triple-network and mechanical training.
34126151	3	1	theme	crosslinking	532:543	arg1	network					545:551	the first crosslinking network	522:551	the first crosslinking network	522:551	The proposed composite hydrogels were achieved by physically crosslinking HPC with PVA to form the first crosslinking network, in which the HPC fibers could decrease the crosslinking density of PVA matrix and generate a lot of water-rich porous area.
34126151	6	2	theme	PVA	1031:1033	arg1	chains					1035:1040	PVA chains	1031:1040	PVA chains	1031:1040	Especially, the crystalline domains of PVA chains could improve the hydrogel's fatigue resistance, and the orderly arrangement of the crystalline domains achieved through mechanical training process could further enhance the mechanical strength.
34126151	7	3	theme	pre-stretched	1265:1277	arg1	hydrogel					1289:1296	pre-stretched composite hydrogel	1265:1296	pre-stretched composite hydrogel	1265:1296	The mechanical strength of pre-stretched composite hydrogel was increased up to 2.8 MPa.
34126151	5	4	theme	mechanical	914:923	arg1	strength					925:932	the mechanical strength	910:932	the mechanical strength	910:932	The formation of triple-network enhanced the mechanical strength and toughness to 1.87 MPa and 339.09 kJ/m3, respectively.
34126151	1	5	theme	excellent	191:199	arg1	conductivity					201:212	excellent conductivity	191:212	excellent conductivity	191:212	To develop the hydrogels with high mechanical strength and excellent conductivity is always a challenging topic.
34126151	7	6	theme	mechanical	1242:1251	arg1	strength					1253:1260	The mechanical strength	1238:1260	The mechanical strength of pre-stretched composite hydrogel	1238:1296	The mechanical strength of pre-stretched composite hydrogel was increased up to 2.8 MPa.
34126151	2	7	theme	alcohol	317:323	arg1	hydrogels					341:349	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels	260:349	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels	260:349	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	6	8	theme	training	1174:1181	arg1	process					1183:1189	mechanical training process	1163:1189	mechanical training process	1163:1189	Especially, the crystalline domains of PVA chains could improve the hydrogel's fatigue resistance, and the orderly arrangement of the crystalline domains achieved through mechanical training process could further enhance the mechanical strength.
34126151	0	9	theme	training	122:129	arg1	combination					77:87	combination	77:87	combination of triple-network and mechanical training	77:129	Ultra-strong hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel by combination of triple-network and mechanical training.
34126151	6	10	theme	mechanical	1217:1226	arg1	strength					1228:1235	the mechanical strength	1213:1235	the mechanical strength	1213:1235	Especially, the crystalline domains of PVA chains could improve the hydrogel's fatigue resistance, and the orderly arrangement of the crystalline domains achieved through mechanical training process could further enhance the mechanical strength.
34126151	2	11	theme	/polyvinyl	306:315	arg1	PVA					326:328	PVA	326:328	PVA	326:328	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	2	11	theme	/polyvinyl	306:315	arg1	alcohol					317:323	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol	260:323	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels	260:349	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	6	12	theme	crystalline	1008:1018	arg1	domains					1020:1026	the crystalline domains	1004:1026	the crystalline domains of PVA chains	1004:1040	Especially, the crystalline domains of PVA chains could improve the hydrogel's fatigue resistance, and the orderly arrangement of the crystalline domains achieved through mechanical training process could further enhance the mechanical strength.
34126151	6	12	theme	crystalline	1008:1018	arg1	chains					1035:1040	PVA chains	1031:1040	PVA chains	1031:1040	Especially, the crystalline domains of PVA chains could improve the hydrogel's fatigue resistance, and the orderly arrangement of the crystalline domains achieved through mechanical training process could further enhance the mechanical strength.
34126151	4	13	theme	cross-linked	847:858	arg1	domains					860:866	cross-linked domains	847:866	cross-linked domains	847:866	Then, 2-hydroxyethyl acrylate (HEA), acrylamide (AM) and aluminium chloride diffused into the first network to fabricate the chemical crosslinking network and ionically cross-linked domains.
34126151	6	14	theme	fatigue	1071:1077	arg1	resistance					1079:1088	the hydrogel's fatigue resistance	1056:1088	the hydrogel's fatigue resistance	1056:1088	Especially, the crystalline domains of PVA chains could improve the hydrogel's fatigue resistance, and the orderly arrangement of the crystalline domains achieved through mechanical training process could further enhance the mechanical strength.
34126151	4	15	theme	first	772:776	arg1	network					778:784	the first network	768:784	the first network	768:784	Then, 2-hydroxyethyl acrylate (HEA), acrylamide (AM) and aluminium chloride diffused into the first network to fabricate the chemical crosslinking network and ionically cross-linked domains.
34126151	4	16	theme	2-hydroxyethyl	684:697	arg1	HEA					709:711	HEA	709:711	HEA	709:711	Then, 2-hydroxyethyl acrylate (HEA), acrylamide (AM) and aluminium chloride diffused into the first network to fabricate the chemical crosslinking network and ionically cross-linked domains.
34126151	4	16	theme	2-hydroxyethyl	684:697	arg1	acrylate					699:706	2-hydroxyethyl acrylate	684:706	2-hydroxyethyl acrylate (HEA)	684:712	Then, 2-hydroxyethyl acrylate (HEA), acrylamide (AM) and aluminium chloride diffused into the first network to fabricate the chemical crosslinking network and ionically cross-linked domains.
34126151	6	17	theme	orderly	1099:1105	arg1	arrangement					1107:1117	the orderly arrangement	1095:1117	the orderly arrangement of the crystalline domains achieved through mechanical training process	1095:1189	Especially, the crystalline domains of PVA chains could improve the hydrogel's fatigue resistance, and the orderly arrangement of the crystalline domains achieved through mechanical training process could further enhance the mechanical strength.
34126151	2	18	theme	HPC	302:304	arg1	PVA					326:328	PVA	326:328	PVA	326:328	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	2	18	theme	HPC	302:304	arg1	alcohol					317:323	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol	260:323	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels	260:349	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	2	19	theme	training	417:424	arg1	combination					368:378	combination	368:378	combination of the triple-network and mechanical training	368:424	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	0	20	theme	hydroxypropyl	13:25	arg1	hydrogel					65:72	hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel	13:72	hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel	13:72	Ultra-strong hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel by combination of triple-network and mechanical training.
34126151	7	21	theme	composite	1279:1287	arg1	hydrogel					1289:1296	pre-stretched composite hydrogel	1265:1296	pre-stretched composite hydrogel	1265:1296	The mechanical strength of pre-stretched composite hydrogel was increased up to 2.8 MPa.
34126151	2	22	theme	composite	331:339	arg1	hydrogels					341:349	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels	260:349	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels	260:349	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	2	23	theme	mechanical	406:415	arg1	training					417:424	the triple-network and mechanical training	383:424	the triple-network and mechanical training	383:424	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	1	24	with	hydrogels	147:155	arg1	strength					178:185	high mechanical strength	162:185	high mechanical strength	162:185	To develop the hydrogels with high mechanical strength and excellent conductivity is always a challenging topic.
34126151	1	24	with	hydrogels	147:155	arg1	conductivity					201:212	excellent conductivity	191:212	excellent conductivity	191:212	To develop the hydrogels with high mechanical strength and excellent conductivity is always a challenging topic.
34126151	3	25	theme	crosslinking	597:608	arg1	density					610:616	the crosslinking density	593:616	the crosslinking density of PVA matrix	593:630	The proposed composite hydrogels were achieved by physically crosslinking HPC with PVA to form the first crosslinking network, in which the HPC fibers could decrease the crosslinking density of PVA matrix and generate a lot of water-rich porous area.
34126151	8	26	theme	wearable	1422:1429	arg1	devices					1431:1437	wearable devices	1422:1437	wearable devices	1422:1437	The composite hydrogels exhibit great applications in sensors, human-machine interactions, and wearable devices.
34126151	5	27	theme	triple-network	886:899	arg1	formation					873:881	The formation	869:881	The formation of triple-network	869:899	The formation of triple-network enhanced the mechanical strength and toughness to 1.87 MPa and 339.09 kJ/m3, respectively.
34126151	0	28	theme	alcohol	47:53	arg1	hydrogel					65:72	hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel	13:72	hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel	13:72	Ultra-strong hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel by combination of triple-network and mechanical training.
34126151	4	29	theme	crosslinking	812:823	arg1	network					825:831	the chemical crosslinking network	799:831	the chemical crosslinking network	799:831	Then, 2-hydroxyethyl acrylate (HEA), acrylamide (AM) and aluminium chloride diffused into the first network to fabricate the chemical crosslinking network and ionically cross-linked domains.
34126151	1	30	theme	challenging	226:236	arg1	topic					238:242	a challenging topic	224:242	a challenging topic	224:242	To develop the hydrogels with high mechanical strength and excellent conductivity is always a challenging topic.
34126151	0	31	theme	cellulose/polyvinyl	27:45	arg1	hydrogel					65:72	hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel	13:72	hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel	13:72	Ultra-strong hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel by combination of triple-network and mechanical training.
34126151	7	32	dep	2.8 MPa	1318:1324	arg1	up					1312:1313	up	1312:1313	up	1312:1313	The mechanical strength of pre-stretched composite hydrogel was increased up to 2.8 MPa.
34126151	3	33	with	HPC	501:503	arg1	PVA					510:512	PVA	510:512	PVA	510:512	The proposed composite hydrogels were achieved by physically crosslinking HPC with PVA to form the first crosslinking network, in which the HPC fibers could decrease the crosslinking density of PVA matrix and generate a lot of water-rich porous area.
34126151	3	34	theme	porous	665:670	arg1	area					672:675	water-rich porous area	654:675	water-rich porous area	654:675	The proposed composite hydrogels were achieved by physically crosslinking HPC with PVA to form the first crosslinking network, in which the HPC fibers could decrease the crosslinking density of PVA matrix and generate a lot of water-rich porous area.
34126151	4	35	theme	aluminium	735:743	arg1	chloride					745:752	aluminium chloride	735:752	aluminium chloride	735:752	Then, 2-hydroxyethyl acrylate (HEA), acrylamide (AM) and aluminium chloride diffused into the first network to fabricate the chemical crosslinking network and ionically cross-linked domains.
34126151	8	36	from	applications	1365:1376	arg1	sensors					1381:1387	sensors	1381:1387	sensors	1381:1387	The composite hydrogels exhibit great applications in sensors, human-machine interactions, and wearable devices.
34126151	8	36	from	applications	1365:1376	arg1	interactions					1404:1415	human-machine interactions	1390:1415	human-machine interactions	1390:1415	The composite hydrogels exhibit great applications in sensors, human-machine interactions, and wearable devices.
34126151	8	36	from	applications	1365:1376	arg1	devices					1431:1437	wearable devices	1422:1437	wearable devices	1422:1437	The composite hydrogels exhibit great applications in sensors, human-machine interactions, and wearable devices.
34126151	1	37	theme	mechanical	167:176	arg1	strength					178:185	high mechanical strength	162:185	high mechanical strength	162:185	To develop the hydrogels with high mechanical strength and excellent conductivity is always a challenging topic.
34126151	3	38	theme	composite	440:448	arg1	hydrogels					450:458	The proposed composite hydrogels	427:458	The proposed composite hydrogels	427:458	The proposed composite hydrogels were achieved by physically crosslinking HPC with PVA to form the first crosslinking network, in which the HPC fibers could decrease the crosslinking density of PVA matrix and generate a lot of water-rich porous area.
34126151	3	39	theme	area	672:675	arg1	area					672:675	water-rich porous area	654:675	water-rich porous area	654:675	The proposed composite hydrogels were achieved by physically crosslinking HPC with PVA to form the first crosslinking network, in which the HPC fibers could decrease the crosslinking density of PVA matrix and generate a lot of water-rich porous area.
34126151	3	39	theme	area	672:675	arg1	lot					647:649	a lot	645:649	a lot of water-rich porous area	645:675	The proposed composite hydrogels were achieved by physically crosslinking HPC with PVA to form the first crosslinking network, in which the HPC fibers could decrease the crosslinking density of PVA matrix and generate a lot of water-rich porous area.
34126151	3	40	theme	PVA	621:623	arg1	matrix					625:630	PVA matrix	621:630	PVA matrix	621:630	The proposed composite hydrogels were achieved by physically crosslinking HPC with PVA to form the first crosslinking network, in which the HPC fibers could decrease the crosslinking density of PVA matrix and generate a lot of water-rich porous area.
34126151	8	41	theme	composite	1331:1339	arg1	hydrogels					1341:1349	The composite hydrogels	1327:1349	The composite hydrogels	1327:1349	The composite hydrogels exhibit great applications in sensors, human-machine interactions, and wearable devices.
34126151	0	42	theme	composite	55:63	arg1	hydrogel					65:72	hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel	13:72	hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel	13:72	Ultra-strong hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel by combination of triple-network and mechanical training.
34126151	3	43	theme	matrix	625:630	arg1	density					610:616	the crosslinking density	593:616	the crosslinking density of PVA matrix	593:630	The proposed composite hydrogels were achieved by physically crosslinking HPC with PVA to form the first crosslinking network, in which the HPC fibers could decrease the crosslinking density of PVA matrix and generate a lot of water-rich porous area.
34126151	8	44	theme	great	1359:1363	arg1	applications					1365:1376	great applications	1359:1376	great applications in sensors, human-machine interactions, and wearable devices	1359:1437	The composite hydrogels exhibit great applications in sensors, human-machine interactions, and wearable devices.
34126151	4	45	link	cross-linked	847:858	arg1	domains					860:866	cross-linked domains	847:866	cross-linked domains	847:866	Then, 2-hydroxyethyl acrylate (HEA), acrylamide (AM) and aluminium chloride diffused into the first network to fabricate the chemical crosslinking network and ionically cross-linked domains.
34126151	3	46	theme	water-rich	654:663	arg1	area					672:675	water-rich porous area	654:675	water-rich porous area	654:675	The proposed composite hydrogels were achieved by physically crosslinking HPC with PVA to form the first crosslinking network, in which the HPC fibers could decrease the crosslinking density of PVA matrix and generate a lot of water-rich porous area.
34126151	6	47	theme	crystalline	1126:1136	arg1	domains					1138:1144	the crystalline domains	1122:1144	the crystalline domains achieved through mechanical training process	1122:1189	Especially, the crystalline domains of PVA chains could improve the hydrogel's fatigue resistance, and the orderly arrangement of the crystalline domains achieved through mechanical training process could further enhance the mechanical strength.
34126151	6	48	theme	mechanical	1163:1172	arg1	process					1183:1189	mechanical training process	1163:1189	mechanical training process	1163:1189	Especially, the crystalline domains of PVA chains could improve the hydrogel's fatigue resistance, and the orderly arrangement of the crystalline domains achieved through mechanical training process could further enhance the mechanical strength.
34126151	3	49	theme	proposed	431:438	arg1	hydrogels					450:458	The proposed composite hydrogels	427:458	The proposed composite hydrogels	427:458	The proposed composite hydrogels were achieved by physically crosslinking HPC with PVA to form the first crosslinking network, in which the HPC fibers could decrease the crosslinking density of PVA matrix and generate a lot of water-rich porous area.
34126151	3	50	theme	first	526:530	arg1	network					545:551	the first crosslinking network	522:551	the first crosslinking network	522:551	The proposed composite hydrogels were achieved by physically crosslinking HPC with PVA to form the first crosslinking network, in which the HPC fibers could decrease the crosslinking density of PVA matrix and generate a lot of water-rich porous area.
34126151	4	51	theme	chemical	803:810	arg1	network					825:831	the chemical crosslinking network	799:831	the chemical crosslinking network	799:831	Then, 2-hydroxyethyl acrylate (HEA), acrylamide (AM) and aluminium chloride diffused into the first network to fabricate the chemical crosslinking network and ionically cross-linked domains.
34126151	6	52	theme	domains	1138:1144	arg1	arrangement					1107:1117	the orderly arrangement	1095:1117	the orderly arrangement of the crystalline domains achieved through mechanical training process	1095:1189	Especially, the crystalline domains of PVA chains could improve the hydrogel's fatigue resistance, and the orderly arrangement of the crystalline domains achieved through mechanical training process could further enhance the mechanical strength.
34126151	2	53	theme	cellulose	291:299	arg1	PVA					326:328	PVA	326:328	PVA	326:328	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	2	53	theme	cellulose	291:299	arg1	alcohol					317:323	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol	260:323	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels	260:349	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	1	54	theme	high	162:165	arg1	strength					178:185	high mechanical strength	162:185	high mechanical strength	162:185	To develop the hydrogels with high mechanical strength and excellent conductivity is always a challenging topic.
34126151	8	55	theme	human-machine	1390:1402	arg1	interactions					1404:1415	human-machine interactions	1390:1415	human-machine interactions	1390:1415	The composite hydrogels exhibit great applications in sensors, human-machine interactions, and wearable devices.
34126151	0	56	theme	triple-network	92:105	arg1	training					122:129	triple-network and mechanical training	92:129	triple-network and mechanical training	92:129	Ultra-strong hydroxypropyl cellulose/polyvinyl alcohol composite hydrogel by combination of triple-network and mechanical training.
34126151	2	57	theme	hydroxypropyl	277:289	arg1	PVA					326:328	PVA	326:328	PVA	326:328	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	2	57	theme	hydroxypropyl	277:289	arg1	alcohol					317:323	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol	260:323	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels	260:349	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	2	58	theme	triple-network	387:400	arg1	training					417:424	the triple-network and mechanical training	383:424	the triple-network and mechanical training	383:424	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	7	59	theme	hydrogel	1289:1296	arg1	strength					1253:1260	The mechanical strength	1238:1260	The mechanical strength of pre-stretched composite hydrogel	1238:1296	The mechanical strength of pre-stretched composite hydrogel was increased up to 2.8 MPa.
34126151	3	60	theme	HPC	567:569	arg1	fibers					571:576	the HPC fibers	563:576	the HPC fibers	563:576	The proposed composite hydrogels were achieved by physically crosslinking HPC with PVA to form the first crosslinking network, in which the HPC fibers could decrease the crosslinking density of PVA matrix and generate a lot of water-rich porous area.
34126151	2	61	theme	ultra-strong	264:275	arg1	PVA					326:328	PVA	326:328	PVA	326:328	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	2	61	theme	ultra-strong	264:275	arg1	alcohol					317:323	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol	260:323	the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels	260:349	In this study, the ultra-strong hydroxypropyl cellulose (HPC)/polyvinyl alcohol (PVA) composite hydrogels were prepared by combination of the triple-network and mechanical training.
34126151	6	62	theme	chains	1035:1040	arg1	domains					1020:1026	the crystalline domains	1004:1026	the crystalline domains of PVA chains	1004:1040	Especially, the crystalline domains of PVA chains could improve the hydrogel's fatigue resistance, and the orderly arrangement of the crystalline domains achieved through mechanical training process could further enhance the mechanical strength.
34126151	6	62	theme	chains	1035:1040	arg1	chains					1035:1040	PVA chains	1031:1040	PVA chains	1031:1040	Especially, the crystalline domains of PVA chains could improve the hydrogel's fatigue resistance, and the orderly arrangement of the crystalline domains achieved through mechanical training process could further enhance the mechanical strength.
34705326	4	0	theme	diverse	691:697	arg1	scales					706:711	diverse length scales	691:711	diverse length scales	691:711	The mechanical properties of pseudo catenoid architecture are revealed for the first time to be controlled at two stages on diverse length scales.
34705326	3	1	with	catenoids	499:507	arg1	birefringence					523:535	distinct birefringence	514:535	distinct birefringence	514:535	Aligned CNCs endow the pseudo catenoids with distinct birefringence in addition to reinforcement.
34705326	2	2	theme	catenoid	341:348	arg1	xerogels					357:364	pseudo catenoid hollow xerogels	334:364	pseudo catenoid hollow xerogels with aligned CNCs	334:382	Herein, complex 3D architectures as pseudo catenoid hollow xerogels with aligned CNCs are prepared from dynamic hydrogels by mechanical stretching and air-drying process.
34705326	6	3	theme	conducive	899:907	arg1	structure					889:897	the structure	885:897	the structure conducive to energy dissipation	885:929	The inwardly curved surface of the pseudo catenoid xerogel makes the structure conducive to energy dissipation.
34705326	4	4	theme	pseudo	596:601	arg1	architecture					612:623	pseudo catenoid architecture	596:623	pseudo catenoid architecture	596:623	The mechanical properties of pseudo catenoid architecture are revealed for the first time to be controlled at two stages on diverse length scales.
34705326	6	5	theme	energy	912:917	arg1	dissipation					919:929	energy dissipation	912:929	energy dissipation	912:929	The inwardly curved surface of the pseudo catenoid xerogel makes the structure conducive to energy dissipation.
34705326	6	6	theme	curved	833:838	arg1	surface					840:846	The inwardly curved surface	820:846	The inwardly curved surface of the pseudo catenoid xerogel	820:877	The inwardly curved surface of the pseudo catenoid xerogel makes the structure conducive to energy dissipation.
34705326	1	7	theme	much	168:171	arg1	attention					173:181	much attention	168:181	much attention	168:181	Advanced materials with aligned cellulose nanocrystals (CNCs) have attracted much attention due to their remarkable mechanical and optical properties, but most of them still focus on 1D or 2D architectures.
34705326	6	8	theme	pseudo	855:860	arg1	xerogel					871:877	the pseudo catenoid xerogel	851:877	the pseudo catenoid xerogel	851:877	The inwardly curved surface of the pseudo catenoid xerogel makes the structure conducive to energy dissipation.
34705326	1	9	dep	1D	274:275	arg1	architectures					283:295	architectures	283:295	architectures	283:295	Advanced materials with aligned cellulose nanocrystals (CNCs) have attracted much attention due to their remarkable mechanical and optical properties, but most of them still focus on 1D or 2D architectures.
34705326	2	10	theme	pseudo	334:339	arg1	xerogels					357:364	pseudo catenoid hollow xerogels	334:364	pseudo catenoid hollow xerogels with aligned CNCs	334:382	Herein, complex 3D architectures as pseudo catenoid hollow xerogels with aligned CNCs are prepared from dynamic hydrogels by mechanical stretching and air-drying process.
34705326	7	11	theme	mechanical	969:978	arg1	properties					980:989	the mechanical properties	965:989	the mechanical properties	965:989	These both stages of controls on the mechanical properties can be adjusted by changing the morphology of the initial hydrogels and the mechanical stretching ratios.
34705326	4	12	theme	architecture	612:623	arg1	properties					582:591	The mechanical properties	567:591	The mechanical properties of pseudo catenoid architecture	567:623	The mechanical properties of pseudo catenoid architecture are revealed for the first time to be controlled at two stages on diverse length scales.
34705326	4	13	theme	first	646:650	arg1	time					652:655	the first time	642:655	the first time	642:655	The mechanical properties of pseudo catenoid architecture are revealed for the first time to be controlled at two stages on diverse length scales.
34705326	4	14	from	stages	681:686	arg1	scales					706:711	diverse length scales	691:711	diverse length scales	691:711	The mechanical properties of pseudo catenoid architecture are revealed for the first time to be controlled at two stages on diverse length scales.
34705326	4	15	theme	catenoid	603:610	arg1	architecture					612:623	pseudo catenoid architecture	596:623	pseudo catenoid architecture	596:623	The mechanical properties of pseudo catenoid architecture are revealed for the first time to be controlled at two stages on diverse length scales.
34705326	4	16	theme	length	699:704	arg1	scales					706:711	diverse length scales	691:711	diverse length scales	691:711	The mechanical properties of pseudo catenoid architecture are revealed for the first time to be controlled at two stages on diverse length scales.
34705326	2	17	theme	dynamic	402:408	arg1	hydrogels					410:418	dynamic hydrogels	402:418	dynamic hydrogels	402:418	Herein, complex 3D architectures as pseudo catenoid hollow xerogels with aligned CNCs are prepared from dynamic hydrogels by mechanical stretching and air-drying process.
34705326	7	18	from	controls	953:960	arg1	properties					980:989	the mechanical properties	965:989	the mechanical properties	965:989	These both stages of controls on the mechanical properties can be adjusted by changing the morphology of the initial hydrogels and the mechanical stretching ratios.
34705326	8	19	theme	advanced	1173:1180	arg1	materials					1182:1190	advanced materials	1173:1190	advanced materials with tailored mechanical properties and functions	1173:1240	These results will provide a new perspective for the design and manufacture advanced materials with tailored mechanical properties and functions.
34705326	5	20	theme	mechanical	797:806	arg1	properties					808:817	the mechanical properties	793:817	the mechanical properties	793:817	Both the aligned CNCs on the nanoscale and the geometry of the xerogels affect the mechanical properties.
34705326	8	21	with	materials	1182:1190	arg1	functions					1232:1240	functions	1232:1240	functions	1232:1240	These results will provide a new perspective for the design and manufacture advanced materials with tailored mechanical properties and functions.
34705326	8	21	with	materials	1182:1190	arg1	properties					1217:1226	tailored mechanical properties	1197:1226	tailored mechanical properties	1197:1226	These results will provide a new perspective for the design and manufacture advanced materials with tailored mechanical properties and functions.
34705326	0	22	theme	Hollow	3:8	arg1	Xerogels					10:17	3D Hollow Xerogels	0:17	3D Hollow Xerogels with Ordered Cellulose Nanocrystals for Tailored Mechanical Properties.	0:89	3D Hollow Xerogels with Ordered Cellulose Nanocrystals for Tailored Mechanical Properties.
34705326	7	23	theme	ratios	1089:1094	arg1	morphology					1023:1032	the morphology	1019:1032	the morphology of the initial hydrogels and the mechanical stretching ratios	1019:1094	These both stages of controls on the mechanical properties can be adjusted by changing the morphology of the initial hydrogels and the mechanical stretching ratios.
34705326	1	24	theme	Advanced	91:98	arg1	materials					100:108	Advanced materials	91:108	Advanced materials with aligned cellulose nanocrystals (CNCs)	91:151	Advanced materials with aligned cellulose nanocrystals (CNCs) have attracted much attention due to their remarkable mechanical and optical properties, but most of them still focus on 1D or 2D architectures.
34705326	2	25	theme	aligned	371:377	arg1	CNCs					379:382	aligned CNCs	371:382	aligned CNCs	371:382	Herein, complex 3D architectures as pseudo catenoid hollow xerogels with aligned CNCs are prepared from dynamic hydrogels by mechanical stretching and air-drying process.
34705326	0	26	theme	3D	0:1	arg1	Xerogels					10:17	3D Hollow Xerogels	0:17	3D Hollow Xerogels with Ordered Cellulose Nanocrystals for Tailored Mechanical Properties.	0:89	3D Hollow Xerogels with Ordered Cellulose Nanocrystals for Tailored Mechanical Properties.
34705326	2	27	theme	mechanical	423:432	arg1	stretching					434:443	mechanical stretching	423:443	mechanical stretching	423:443	Herein, complex 3D architectures as pseudo catenoid hollow xerogels with aligned CNCs are prepared from dynamic hydrogels by mechanical stretching and air-drying process.
34705326	7	28	theme	mechanical	1067:1076	arg1	ratios					1089:1094	the mechanical stretching ratios	1063:1094	the mechanical stretching ratios	1063:1094	These both stages of controls on the mechanical properties can be adjusted by changing the morphology of the initial hydrogels and the mechanical stretching ratios.
34705326	1	29	theme	remarkable	196:205	arg1	properties					230:239	their remarkable mechanical and optical properties	190:239	their remarkable mechanical and optical properties	190:239	Advanced materials with aligned cellulose nanocrystals (CNCs) have attracted much attention due to their remarkable mechanical and optical properties, but most of them still focus on 1D or 2D architectures.
34705326	1	30	with	materials	100:108	arg1	CNCs					147:150	CNCs	147:150	CNCs	147:150	Advanced materials with aligned cellulose nanocrystals (CNCs) have attracted much attention due to their remarkable mechanical and optical properties, but most of them still focus on 1D or 2D architectures.
34705326	1	30	with	materials	100:108	arg1	nanocrystals					133:144	aligned cellulose nanocrystals	115:144	aligned cellulose nanocrystals (CNCs)	115:151	Advanced materials with aligned cellulose nanocrystals (CNCs) have attracted much attention due to their remarkable mechanical and optical properties, but most of them still focus on 1D or 2D architectures.
34705326	7	31	theme	stretching	1078:1087	arg1	ratios					1089:1094	the mechanical stretching ratios	1063:1094	the mechanical stretching ratios	1063:1094	These both stages of controls on the mechanical properties can be adjusted by changing the morphology of the initial hydrogels and the mechanical stretching ratios.
34705326	6	32	theme	xerogel	871:877	arg1	surface					840:846	The inwardly curved surface	820:846	The inwardly curved surface of the pseudo catenoid xerogel	820:877	The inwardly curved surface of the pseudo catenoid xerogel makes the structure conducive to energy dissipation.
34705326	1	33	theme	aligned	115:121	arg1	CNCs					147:150	CNCs	147:150	CNCs	147:150	Advanced materials with aligned cellulose nanocrystals (CNCs) have attracted much attention due to their remarkable mechanical and optical properties, but most of them still focus on 1D or 2D architectures.
34705326	1	33	theme	aligned	115:121	arg1	nanocrystals					133:144	aligned cellulose nanocrystals	115:144	aligned cellulose nanocrystals (CNCs)	115:151	Advanced materials with aligned cellulose nanocrystals (CNCs) have attracted much attention due to their remarkable mechanical and optical properties, but most of them still focus on 1D or 2D architectures.
34705326	1	34	theme	mechanical	207:216	arg1	properties					230:239	their remarkable mechanical and optical properties	190:239	their remarkable mechanical and optical properties	190:239	Advanced materials with aligned cellulose nanocrystals (CNCs) have attracted much attention due to their remarkable mechanical and optical properties, but most of them still focus on 1D or 2D architectures.
34705326	0	35	theme	Cellulose	32:40	arg1	Nanocrystals					42:53	Ordered Cellulose Nanocrystals	24:53	Ordered Cellulose Nanocrystals	24:53	3D Hollow Xerogels with Ordered Cellulose Nanocrystals for Tailored Mechanical Properties.
34705326	4	36	theme	mechanical	571:580	arg1	properties					582:591	The mechanical properties	567:591	The mechanical properties of pseudo catenoid architecture	567:623	The mechanical properties of pseudo catenoid architecture are revealed for the first time to be controlled at two stages on diverse length scales.
34705326	6	37	theme	catenoid	862:869	arg1	xerogel					871:877	the pseudo catenoid xerogel	851:877	the pseudo catenoid xerogel	851:877	The inwardly curved surface of the pseudo catenoid xerogel makes the structure conducive to energy dissipation.
34705326	5	38	theme	aligned	723:729	arg1	CNCs					731:734	the aligned CNCs	719:734	the aligned CNCs on the nanoscale	719:751	Both the aligned CNCs on the nanoscale and the geometry of the xerogels affect the mechanical properties.
34705326	0	39	theme	Ordered	24:30	arg1	Nanocrystals					42:53	Ordered Cellulose Nanocrystals	24:53	Ordered Cellulose Nanocrystals	24:53	3D Hollow Xerogels with Ordered Cellulose Nanocrystals for Tailored Mechanical Properties.
34705326	5	40	theme	xerogels	777:784	arg1	CNCs					731:734	the aligned CNCs	719:734	the aligned CNCs on the nanoscale	719:751	Both the aligned CNCs on the nanoscale and the geometry of the xerogels affect the mechanical properties.
34705326	5	40	theme	xerogels	777:784	arg1	geometry					761:768	the geometry	757:768	the geometry of the xerogels	757:784	Both the aligned CNCs on the nanoscale and the geometry of the xerogels affect the mechanical properties.
34705326	5	41	from	CNCs	731:734	arg1	nanoscale					743:751	nanoscale	743:751	nanoscale	743:751	Both the aligned CNCs on the nanoscale and the geometry of the xerogels affect the mechanical properties.
34705326	1	42	theme	optical	222:228	arg1	properties					230:239	their remarkable mechanical and optical properties	190:239	their remarkable mechanical and optical properties	190:239	Advanced materials with aligned cellulose nanocrystals (CNCs) have attracted much attention due to their remarkable mechanical and optical properties, but most of them still focus on 1D or 2D architectures.
34705326	7	43	theme	initial	1041:1047	arg1	hydrogels					1049:1057	the initial hydrogels	1037:1057	the initial hydrogels	1037:1057	These both stages of controls on the mechanical properties can be adjusted by changing the morphology of the initial hydrogels and the mechanical stretching ratios.
34705326	0	44	with	Xerogels	10:17	arg1	Nanocrystals					42:53	Ordered Cellulose Nanocrystals	24:53	Ordered Cellulose Nanocrystals	24:53	3D Hollow Xerogels with Ordered Cellulose Nanocrystals for Tailored Mechanical Properties.
34705326	1	45	theme	cellulose	123:131	arg1	CNCs					147:150	CNCs	147:150	CNCs	147:150	Advanced materials with aligned cellulose nanocrystals (CNCs) have attracted much attention due to their remarkable mechanical and optical properties, but most of them still focus on 1D or 2D architectures.
34705326	1	45	theme	cellulose	123:131	arg1	nanocrystals					133:144	aligned cellulose nanocrystals	115:144	aligned cellulose nanocrystals (CNCs)	115:151	Advanced materials with aligned cellulose nanocrystals (CNCs) have attracted much attention due to their remarkable mechanical and optical properties, but most of them still focus on 1D or 2D architectures.
34705326	2	46	theme	air-drying	449:458	arg1	process					460:466	air-drying process	449:466	air-drying process	449:466	Herein, complex 3D architectures as pseudo catenoid hollow xerogels with aligned CNCs are prepared from dynamic hydrogels by mechanical stretching and air-drying process.
34705326	7	47	theme	hydrogels	1049:1057	arg1	morphology					1023:1032	the morphology	1019:1032	the morphology of the initial hydrogels and the mechanical stretching ratios	1019:1094	These both stages of controls on the mechanical properties can be adjusted by changing the morphology of the initial hydrogels and the mechanical stretching ratios.
34705326	5	48	from	geometry	761:768	arg1	nanoscale					743:751	nanoscale	743:751	nanoscale	743:751	Both the aligned CNCs on the nanoscale and the geometry of the xerogels affect the mechanical properties.
34705326	3	49	theme	pseudo	492:497	arg1	catenoids					499:507	the pseudo catenoids	488:507	the pseudo catenoids with distinct birefringence in addition to reinforcement	488:564	Aligned CNCs endow the pseudo catenoids with distinct birefringence in addition to reinforcement.
34705326	8	50	theme	tailored	1197:1204	arg1	properties					1217:1226	tailored mechanical properties	1197:1226	tailored mechanical properties	1197:1226	These results will provide a new perspective for the design and manufacture advanced materials with tailored mechanical properties and functions.
34705326	8	51	theme	new	1126:1128	arg1	perspective					1130:1140	a new perspective	1124:1140	a new perspective for the design	1124:1155	These results will provide a new perspective for the design and manufacture advanced materials with tailored mechanical properties and functions.
34705326	2	52	theme	3D	314:315	arg1	architectures					317:329	complex 3D architectures	306:329	complex 3D architectures as pseudo catenoid hollow xerogels with aligned CNCs	306:382	Herein, complex 3D architectures as pseudo catenoid hollow xerogels with aligned CNCs are prepared from dynamic hydrogels by mechanical stretching and air-drying process.
34705326	2	53	with	xerogels	357:364	arg1	CNCs					379:382	aligned CNCs	371:382	aligned CNCs	371:382	Herein, complex 3D architectures as pseudo catenoid hollow xerogels with aligned CNCs are prepared from dynamic hydrogels by mechanical stretching and air-drying process.
34705326	2	54	theme	complex	306:312	arg1	architectures					317:329	complex 3D architectures	306:329	complex 3D architectures as pseudo catenoid hollow xerogels with aligned CNCs	306:382	Herein, complex 3D architectures as pseudo catenoid hollow xerogels with aligned CNCs are prepared from dynamic hydrogels by mechanical stretching and air-drying process.
34705326	3	55	theme	Aligned	469:475	arg1	CNCs					477:480	Aligned CNCs	469:480	Aligned CNCs	469:480	Aligned CNCs endow the pseudo catenoids with distinct birefringence in addition to reinforcement.
34705326	0	56	theme	Mechanical	68:77	arg1	Properties					79:88	Tailored Mechanical Properties	59:88	Tailored Mechanical Properties	59:88	3D Hollow Xerogels with Ordered Cellulose Nanocrystals for Tailored Mechanical Properties.
34705326	3	57	theme	distinct	514:521	arg1	birefringence					523:535	distinct birefringence	514:535	distinct birefringence	514:535	Aligned CNCs endow the pseudo catenoids with distinct birefringence in addition to reinforcement.
34705326	0	58	theme	Tailored	59:66	arg1	Properties					79:88	Tailored Mechanical Properties	59:88	Tailored Mechanical Properties	59:88	3D Hollow Xerogels with Ordered Cellulose Nanocrystals for Tailored Mechanical Properties.
34705326	8	59	theme	mechanical	1206:1215	arg1	properties					1217:1226	tailored mechanical properties	1197:1226	tailored mechanical properties	1197:1226	These results will provide a new perspective for the design and manufacture advanced materials with tailored mechanical properties and functions.
34705326	2	60	theme	hollow	350:355	arg1	xerogels					357:364	pseudo catenoid hollow xerogels	334:364	pseudo catenoid hollow xerogels with aligned CNCs	334:382	Herein, complex 3D architectures as pseudo catenoid hollow xerogels with aligned CNCs are prepared from dynamic hydrogels by mechanical stretching and air-drying process.
34705326	7	61	dep	These	932:936	arg1	both					938:941	both	938:941	both	938:941	These both stages of controls on the mechanical properties can be adjusted by changing the morphology of the initial hydrogels and the mechanical stretching ratios.
34893286	0	0	theme	composite	101:109	arg1	scaffold					111:118	substituted calcium phosphate/chitosan composite scaffold	62:118	substituted calcium phosphate/chitosan composite scaffold	62:118	Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold.
34893286	5	1	theme	cells	803:807	arg1	potential					767:775	Osteogenic potential	756:775	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds	756:827	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	5	2	theme	dynamic	939:945	arg1	conditions					947:956	static and dynamic conditions	928:956	static and dynamic conditions	928:956	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	4	3	from	28 days	721:727	arg1	medium					748:753	the degradation medium	732:753	the degradation medium	732:753	The scaffolds have shown highly porous structure, with very well interconnected pores and homogeneously dispersed CaPs, and high stability during 28 days in the degradation medium.
34893286	1	4	theme	tissue	265:270	arg1	applications					284:295	bone tissue engineering applications	260:295	bone tissue engineering applications	260:295	Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications.
34893286	0	5	theme	phosphate/chitosan	82:99	arg1	scaffold					111:118	substituted calcium phosphate/chitosan composite scaffold	62:118	substituted calcium phosphate/chitosan composite scaffold	62:118	Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold.
34893286	0	6	from	differentiation	11:25	arg1	scaffold					111:118	substituted calcium phosphate/chitosan composite scaffold	62:118	substituted calcium phosphate/chitosan composite scaffold	62:118	Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold.
34893286	1	7	theme	biological	181:190	arg1	performance					192:202	the biological performance	177:202	the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications	177:295	Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications.
34893286	1	8	theme	engineering	272:282	arg1	applications					284:295	bone tissue engineering applications	260:295	bone tissue engineering applications	260:295	Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications.
34893286	5	9	theme	Osteogenic	756:765	arg1	potential					767:775	Osteogenic potential	756:775	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds	756:827	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	3	10	theme	composite	428:436	arg1	scaffolds					438:446	highly porous composite scaffolds	414:446	highly porous composite scaffolds based on CaPs substituted with Sr2+, Mg2+, Zn2+ and SeO32- ions, and chitosan	414:524	In this work, highly porous composite scaffolds based on CaPs substituted with Sr2+, Mg2+, Zn2+ and SeO32- ions, and chitosan have been prepared by freeze-gelation technique.
34893286	7	11	with	scaffolds	1205:1213	arg1	CaPs					1236:1239	non-substituted CaPs	1220:1239	non-substituted CaPs	1220:1239	The scaffolds with multi-substituted CaPs have shown increased expression of osteogenesis related markers and increased phosphate deposits, compared to the scaffolds with non-substituted CaPs.
34893286	7	12	theme	non-substituted	1220:1234	arg1	CaPs					1236:1239	non-substituted CaPs	1220:1239	non-substituted CaPs	1220:1239	The scaffolds with multi-substituted CaPs have shown increased expression of osteogenesis related markers and increased phosphate deposits, compared to the scaffolds with non-substituted CaPs.
34893286	2	13	theme	systematic	307:316	arg1	studies					318:324	systematic studies	307:324	systematic studies	307:324	However, systematic studies have not been performed on multi-substituted organic/inorganic scaffolds.
34893286	5	14	theme	RT-qPCR	890:896	arg1	analysis					898:905	histological, immunohistochemical and RT-qPCR analysis	852:905	histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions	852:956	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	7	15	theme	phosphate	1169:1177	arg1	deposits					1179:1186	increased phosphate deposits	1159:1186	increased phosphate deposits	1159:1186	The scaffolds with multi-substituted CaPs have shown increased expression of osteogenesis related markers and increased phosphate deposits, compared to the scaffolds with non-substituted CaPs.
34893286	4	16	theme	high	699:702	arg1	stability					704:712	high stability	699:712	high stability during 28 days in the degradation medium	699:753	The scaffolds have shown highly porous structure, with very well interconnected pores and homogeneously dispersed CaPs, and high stability during 28 days in the degradation medium.
34893286	5	17	theme	human	780:784	arg1	cells					803:807	human mesenchymal stem cells	780:807	human mesenchymal stem cells seeded on scaffolds	780:827	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	4	18	theme	porous	607:612	arg1	structure					614:622	highly porous structure	600:622	highly porous structure	600:622	The scaffolds have shown highly porous structure, with very well interconnected pores and homogeneously dispersed CaPs, and high stability during 28 days in the degradation medium.
34893286	3	19	theme	freeze-gelation	548:562	arg1	technique					564:572	freeze-gelation technique	548:572	freeze-gelation technique	548:572	In this work, highly porous composite scaffolds based on CaPs substituted with Sr2+, Mg2+, Zn2+ and SeO32- ions, and chitosan have been prepared by freeze-gelation technique.
34893286	5	20	theme	cultured	910:917	arg1	cells					919:923	cultured cells	910:923	cultured cells in static and dynamic conditions	910:956	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	3	21	theme	porous	421:426	arg1	scaffolds					438:446	highly porous composite scaffolds	414:446	highly porous composite scaffolds based on CaPs substituted with Sr2+, Mg2+, Zn2+ and SeO32- ions, and chitosan	414:524	In this work, highly porous composite scaffolds based on CaPs substituted with Sr2+, Mg2+, Zn2+ and SeO32- ions, and chitosan have been prepared by freeze-gelation technique.
34893286	5	22	theme	mesenchymal	786:796	arg1	cells					803:807	human mesenchymal stem cells	780:807	human mesenchymal stem cells seeded on scaffolds	780:827	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	2	23	theme	multi-substituted	353:369	arg1	scaffolds					389:397	multi-substituted organic/inorganic scaffolds	353:397	multi-substituted organic/inorganic scaffolds	353:397	However, systematic studies have not been performed on multi-substituted organic/inorganic scaffolds.
34893286	1	24	theme	calcium	207:213	arg1	CaP					227:229	CaP	227:229	CaP	227:229	Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications.
34893286	1	24	theme	calcium	207:213	arg1	phosphates					215:224	calcium phosphates	207:224	calcium phosphates (CaP)	207:230	Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications.
34893286	0	25	theme	Osteogenic	0:9	arg1	differentiation					11:25	Osteogenic differentiation	0:25	Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold.	0:119	Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold.
34893286	7	26	theme	increased	1159:1167	arg1	deposits					1179:1186	increased phosphate deposits	1159:1186	increased phosphate deposits	1159:1186	The scaffolds with multi-substituted CaPs have shown increased expression of osteogenesis related markers and increased phosphate deposits, compared to the scaffolds with non-substituted CaPs.
34893286	7	27	theme	osteogenesis	1126:1137	arg1	markers					1147:1153	osteogenesis related markers	1126:1153	osteogenesis related markers	1126:1153	The scaffolds with multi-substituted CaPs have shown increased expression of osteogenesis related markers and increased phosphate deposits, compared to the scaffolds with non-substituted CaPs.
34893286	7	28	with	scaffolds	1053:1061	arg1	CaPs					1086:1089	multi-substituted CaPs	1068:1089	multi-substituted CaPs	1068:1089	The scaffolds with multi-substituted CaPs have shown increased expression of osteogenesis related markers and increased phosphate deposits, compared to the scaffolds with non-substituted CaPs.
34893286	1	29	theme	phosphates	215:224	arg1	performance					192:202	the biological performance	177:202	the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications	177:295	Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications.
34893286	0	30	theme	human	30:34	arg1	cells					53:57	human mesenchymal stem cells	30:57	human mesenchymal stem cells	30:57	Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold.
34893286	7	31	theme	related	1139:1145	arg1	markers					1147:1153	osteogenesis related markers	1126:1153	osteogenesis related markers	1126:1153	The scaffolds with multi-substituted CaPs have shown increased expression of osteogenesis related markers and increased phosphate deposits, compared to the scaffolds with non-substituted CaPs.
34893286	1	32	theme	Ionic	121:125	arg1	strategy					157:164	a promising strategy	145:164	a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications	145:295	Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications.
34893286	1	32	theme	Ionic	121:125	arg1	substitutions					127:139	Ionic substitutions	121:139	Ionic substitutions	121:139	Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications.
34893286	3	33	theme	Zn2+	491:494	arg1	ions					507:510	Mg2+, Zn2+ and SeO32- ions	485:510	Mg2+, Zn2+ and SeO32- ions	485:510	In this work, highly porous composite scaffolds based on CaPs substituted with Sr2+, Mg2+, Zn2+ and SeO32- ions, and chitosan have been prepared by freeze-gelation technique.
34893286	7	34	theme	markers	1147:1153	arg1	expression					1112:1121	increased expression	1102:1121	increased expression of osteogenesis related markers and increased phosphate deposits	1102:1186	The scaffolds with multi-substituted CaPs have shown increased expression of osteogenesis related markers and increased phosphate deposits, compared to the scaffolds with non-substituted CaPs.
34893286	0	35	theme	stem	48:51	arg1	cells					53:57	human mesenchymal stem cells	30:57	human mesenchymal stem cells	30:57	Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold.
34893286	6	36	theme	beneficial	1009:1018	arg1	effect					1020:1025	a beneficial effect	1007:1025	a beneficial effect	1007:1025	Results indicated that ionic substitutions have a beneficial effect on cells and tissues.
34893286	4	37	theme	dispersed	679:687	arg1	CaPs					689:692	homogeneously dispersed CaPs	665:692	homogeneously dispersed CaPs	665:692	The scaffolds have shown highly porous structure, with very well interconnected pores and homogeneously dispersed CaPs, and high stability during 28 days in the degradation medium.
34893286	3	38	theme	Mg2+	485:488	arg1	ions					507:510	Mg2+, Zn2+ and SeO32- ions	485:510	Mg2+, Zn2+ and SeO32- ions	485:510	In this work, highly porous composite scaffolds based on CaPs substituted with Sr2+, Mg2+, Zn2+ and SeO32- ions, and chitosan have been prepared by freeze-gelation technique.
34893286	0	39	theme	mesenchymal	36:46	arg1	cells					53:57	human mesenchymal stem cells	30:57	human mesenchymal stem cells	30:57	Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold.
34893286	5	40	theme	cells	919:923	arg1	analysis					898:905	histological, immunohistochemical and RT-qPCR analysis	852:905	histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions	852:956	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	5	41	theme	histological	852:863	arg1	analysis					898:905	histological, immunohistochemical and RT-qPCR analysis	852:905	histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions	852:956	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	7	42	theme	multi-substituted	1068:1084	arg1	CaPs					1086:1089	multi-substituted CaPs	1068:1089	multi-substituted CaPs	1068:1089	The scaffolds with multi-substituted CaPs have shown increased expression of osteogenesis related markers and increased phosphate deposits, compared to the scaffolds with non-substituted CaPs.
34893286	7	43	theme	increased	1102:1110	arg1	expression					1112:1121	increased expression	1102:1121	increased expression of osteogenesis related markers and increased phosphate deposits	1102:1186	The scaffolds with multi-substituted CaPs have shown increased expression of osteogenesis related markers and increased phosphate deposits, compared to the scaffolds with non-substituted CaPs.
34893286	5	44	theme	stem	798:801	arg1	cells					803:807	human mesenchymal stem cells	780:807	human mesenchymal stem cells seeded on scaffolds	780:827	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	5	45	from	analysis	898:905	arg1	conditions					947:956	static and dynamic conditions	928:956	static and dynamic conditions	928:956	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	4	46	theme	degradation	736:746	arg1	medium					748:753	the degradation medium	732:753	the degradation medium	732:753	The scaffolds have shown highly porous structure, with very well interconnected pores and homogeneously dispersed CaPs, and high stability during 28 days in the degradation medium.
34893286	0	47	theme	cells	53:57	arg1	differentiation					11:25	Osteogenic differentiation	0:25	Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold.	0:119	Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold.
34893286	3	48	theme	SeO32-	500:505	arg1	ions					507:510	Mg2+, Zn2+ and SeO32- ions	485:510	Mg2+, Zn2+ and SeO32- ions	485:510	In this work, highly porous composite scaffolds based on CaPs substituted with Sr2+, Mg2+, Zn2+ and SeO32- ions, and chitosan have been prepared by freeze-gelation technique.
34893286	4	49	dep	interconnected	640:653	arg1	with					625:628	with	625:628	with	625:628	The scaffolds have shown highly porous structure, with very well interconnected pores and homogeneously dispersed CaPs, and high stability during 28 days in the degradation medium.
34893286	7	50	theme	deposits	1179:1186	arg1	expression					1112:1121	increased expression	1102:1121	increased expression of osteogenesis related markers and increased phosphate deposits	1102:1186	The scaffolds with multi-substituted CaPs have shown increased expression of osteogenesis related markers and increased phosphate deposits, compared to the scaffolds with non-substituted CaPs.
34893286	2	51	theme	organic/inorganic	371:387	arg1	scaffolds					389:397	multi-substituted organic/inorganic scaffolds	353:397	multi-substituted organic/inorganic scaffolds	353:397	However, systematic studies have not been performed on multi-substituted organic/inorganic scaffolds.
34893286	6	52	theme	ionic	982:986	arg1	substitutions					988:1000	ionic substitutions	982:1000	ionic substitutions	982:1000	Results indicated that ionic substitutions have a beneficial effect on cells and tissues.
34893286	5	53	from	conditions	947:956	arg1	analysis					898:905	histological, immunohistochemical and RT-qPCR analysis	852:905	histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions	852:956	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	1	54	theme	promising	147:155	arg1	strategy					157:164	a promising strategy	145:164	a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications	145:295	Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications.
34893286	1	54	theme	promising	147:155	arg1	substitutions					127:139	Ionic substitutions	121:139	Ionic substitutions	121:139	Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications.
34893286	1	55	theme	composite	236:244	arg1	materials					246:254	composite materials	236:254	composite materials	236:254	Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications.
34893286	5	56	from	cells	919:923	arg1	conditions					947:956	static and dynamic conditions	928:956	static and dynamic conditions	928:956	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	1	57	theme	materials	246:254	arg1	performance					192:202	the biological performance	177:202	the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications	177:295	Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications.
34893286	0	58	theme	calcium	74:80	arg1	scaffold					111:118	substituted calcium phosphate/chitosan composite scaffold	62:118	substituted calcium phosphate/chitosan composite scaffold	62:118	Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold.
34893286	6	59	contain	have	1002:1005	arg2	effect					1020:1025	a beneficial effect	1007:1025	a beneficial effect	1007:1025	Results indicated that ionic substitutions have a beneficial effect on cells and tissues.
34893286	6	59	contain	have	1002:1005	arg1	substitutions					988:1000	ionic substitutions	982:1000	ionic substitutions	982:1000	Results indicated that ionic substitutions have a beneficial effect on cells and tissues.
34893286	5	60	theme	immunohistochemical	866:884	arg1	analysis					898:905	histological, immunohistochemical and RT-qPCR analysis	852:905	histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions	852:956	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	5	61	theme	static	928:933	arg1	conditions					947:956	static and dynamic conditions	928:956	static and dynamic conditions	928:956	Osteogenic potential of human mesenchymal stem cells seeded on scaffolds has been determined by histological, immunohistochemical and RT-qPCR analysis of cultured cells in static and dynamic conditions.
34893286	4	62	theme	interconnected	640:653	arg1	pores					655:659	with very well interconnected pores	625:659	with very well interconnected pores	625:659	The scaffolds have shown highly porous structure, with very well interconnected pores and homogeneously dispersed CaPs, and high stability during 28 days in the degradation medium.
34893286	0	63	theme	substituted	62:72	arg1	scaffold					111:118	substituted calcium phosphate/chitosan composite scaffold	62:118	substituted calcium phosphate/chitosan composite scaffold	62:118	Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold.
34893286	1	64	theme	bone	260:263	arg1	applications					284:295	bone tissue engineering applications	260:295	bone tissue engineering applications	260:295	Ionic substitutions are a promising strategy to enhance the biological performance of calcium phosphates (CaP) and composite materials for bone tissue engineering applications.
34774594	0	0	theme	antioxidant	77:87	arg1	property					89:96	antioxidant property	77:96	antioxidant property	77:96	Alginate with citrus pectin and pterostilbene as healthy food packaging with antioxidant property.
34774594	1	1	theme	natural	138:144	arg1	materials					161:169	natural polysaccharide materials	138:169	natural polysaccharide materials	138:169	A new type of film packaging made from natural polysaccharide materials, with its environmental safety and friendliness, is considered as a potential substitute for plastics.
34774594	8	2	theme	antioxidant	1243:1253	arg1	properties					1255:1264	the antioxidant properties	1239:1264	the antioxidant properties of the SA-CP films	1239:1283	Notably, the accretion of PTE expressively enhanced the antioxidant properties of the SA-CP films.
34774594	1	3	theme	polysaccharide	146:159	arg1	materials					161:169	natural polysaccharide materials	138:169	natural polysaccharide materials	138:169	A new type of film packaging made from natural polysaccharide materials, with its environmental safety and friendliness, is considered as a potential substitute for plastics.
34774594	4	4	dep	film	794:797	arg1	both					807:810	both	807:810	both	807:810	The SA-CP films had good tensile strength (TS) and elongation at break (EB), while adding PTE as an antioxidant to the film reduced both the values.
34774594	5	5	theme	SA-CP	837:841	arg1	films					843:847	the SA-CP films	833:847	the SA-CP films with PTE	833:856	Of note, the SA-CP films with PTE had better moisture resistance than that of the pure SA-CP films, which was related to the changes of its microstructure.
34774594	2	6	theme	polysaccharide	280:293	arg1	films					305:309	Novel polysaccharide composite films	274:309	Novel polysaccharide composite films based upon citrus pectin (CP) and sodium alginate (SA)	274:364	Novel polysaccharide composite films based upon citrus pectin (CP) and sodium alginate (SA) were successfully prepared and characterized, containing pterostilbene (PTE) at various concentrations (0.2, 0.4, 0.8, 1.6, 3.2 mM).
34774594	1	7	theme	new	101:103	arg1	potential					239:247	a potential	237:247	a potential substitute for plastics	237:271	A new type of film packaging made from natural polysaccharide materials, with its environmental safety and friendliness, is considered as a potential substitute for plastics.
34774594	1	7	theme	new	101:103	arg1	type					105:108	A new type	99:108	A new type	99:108	A new type of film packaging made from natural polysaccharide materials, with its environmental safety and friendliness, is considered as a potential substitute for plastics.
34774594	4	8	theme	reduced	799:805	arg1	film					794:797	the film reduced both the values	790:821	film	794:797	The SA-CP films had good tensile strength (TS) and elongation at break (EB), while adding PTE as an antioxidant to the film reduced both the values.
34774594	0	9	with	packaging	62:70	arg1	property					89:96	antioxidant property	77:96	antioxidant property	77:96	Alginate with citrus pectin and pterostilbene as healthy food packaging with antioxidant property.
34774594	2	10	theme	Novel	274:278	arg1	films					305:309	Novel polysaccharide composite films	274:309	Novel polysaccharide composite films based upon citrus pectin (CP) and sodium alginate (SA)	274:364	Novel polysaccharide composite films based upon citrus pectin (CP) and sodium alginate (SA) were successfully prepared and characterized, containing pterostilbene (PTE) at various concentrations (0.2, 0.4, 0.8, 1.6, 3.2 mM).
34774594	3	11	with	 > G	602:605	arg1	 < G					650:653	G" < G'	648:654	G" < G' at high frequency	648:672	The rheological analysis displayed that all film-forming liquids performed no gelation behavior with G" > G' at low frequency and weak gelation with G" < G' at high frequency.
34774594	2	12	theme	citrus	322:327	arg1	CP					337:338	CP	337:338	CP	337:338	Novel polysaccharide composite films based upon citrus pectin (CP) and sodium alginate (SA) were successfully prepared and characterized, containing pterostilbene (PTE) at various concentrations (0.2, 0.4, 0.8, 1.6, 3.2 mM).
34774594	2	12	theme	citrus	322:327	arg1	pectin					329:334	citrus pectin	322:334	citrus pectin (CP)	322:339	Novel polysaccharide composite films based upon citrus pectin (CP) and sodium alginate (SA) were successfully prepared and characterized, containing pterostilbene (PTE) at various concentrations (0.2, 0.4, 0.8, 1.6, 3.2 mM).
34774594	9	13	theme	SA-CP	1296:1300	arg1	films					1312:1316	the SA-CP composite films	1292:1316	the SA-CP composite films containing PTE	1292:1331	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	9	13	theme	SA-CP	1296:1300	arg1	material					1389:1396	an excellent antioxidant packaging material	1354:1396	an excellent antioxidant packaging material	1354:1396	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	9	14	theme	excellent	1357:1365	arg1	antioxidant					1367:1377	an excellent antioxidant	1354:1377	an excellent antioxidant packaging material	1354:1396	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	2	15	dep	3.2 mM	490:495	arg1	1.6					485:487	1.6	485:487	1.6	485:487	Novel polysaccharide composite films based upon citrus pectin (CP) and sodium alginate (SA) were successfully prepared and characterized, containing pterostilbene (PTE) at various concentrations (0.2, 0.4, 0.8, 1.6, 3.2 mM).
34774594	3	16	from	frequency	615:623	arg1	 > G					602:605	G" > G'	600:606	G" > G' at low frequency and weak gelation with G" < G' at high frequency	600:672	The rheological analysis displayed that all film-forming liquids performed no gelation behavior with G" > G' at low frequency and weak gelation with G" < G' at high frequency.
34774594	4	17	theme	SA-CP	679:683	arg1	films					685:689	The SA-CP films	675:689	The SA-CP films	675:689	The SA-CP films had good tensile strength (TS) and elongation at break (EB), while adding PTE as an antioxidant to the film reduced both the values.
34774594	3	18	theme	G	648:648	arg1	 < G					650:653	G" < G'	648:654	G" < G' at high frequency	648:672	The rheological analysis displayed that all film-forming liquids performed no gelation behavior with G" > G' at low frequency and weak gelation with G" < G' at high frequency.
34774594	1	19	with	type	105:108	arg1	safety					195:200	its environmental safety	177:200	its environmental safety	177:200	A new type of film packaging made from natural polysaccharide materials, with its environmental safety and friendliness, is considered as a potential substitute for plastics.
34774594	1	19	with	type	105:108	arg1	friendliness					206:217	friendliness	206:217	friendliness	206:217	A new type of film packaging made from natural polysaccharide materials, with its environmental safety and friendliness, is considered as a potential substitute for plastics.
34774594	9	20	theme	antioxidant	1367:1377	arg1	films					1312:1316	the SA-CP composite films	1292:1316	the SA-CP composite films containing PTE	1292:1331	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	9	20	theme	antioxidant	1367:1377	arg1	material					1389:1396	an excellent antioxidant packaging material	1354:1396	an excellent antioxidant packaging material	1354:1396	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	3	21	theme	rheological	503:513	arg1	analysis					515:522	The rheological analysis	499:522	The rheological analysis	499:522	The rheological analysis displayed that all film-forming liquids performed no gelation behavior with G" > G' at low frequency and weak gelation with G" < G' at high frequency.
34774594	9	22	theme	composite	1302:1310	arg1	films					1312:1316	the SA-CP composite films	1292:1316	the SA-CP composite films containing PTE	1292:1331	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	9	22	theme	composite	1302:1310	arg1	material					1389:1396	an excellent antioxidant packaging material	1354:1396	an excellent antioxidant packaging material	1354:1396	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	3	23	theme	high	659:662	arg1	frequency					664:672	high frequency	659:672	high frequency	659:672	The rheological analysis displayed that all film-forming liquids performed no gelation behavior with G" > G' at low frequency and weak gelation with G" < G' at high frequency.
34774594	3	24	from	frequency	664:672	arg1	 < G					650:653	G" < G'	648:654	G" < G' at high frequency	648:672	The rheological analysis displayed that all film-forming liquids performed no gelation behavior with G" > G' at low frequency and weak gelation with G" < G' at high frequency.
34774594	5	25	dep	had	858:860	arg1	related					934:940	related	934:940	related	934:940	Of note, the SA-CP films with PTE had better moisture resistance than that of the pure SA-CP films, which was related to the changes of its microstructure.
34774594	9	26	contain	containing	1318:1327	arg1	films					1312:1316	the SA-CP composite films	1292:1316	the SA-CP composite films containing PTE	1292:1331	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	9	26	contain	containing	1318:1327	arg1	material					1389:1396	an excellent antioxidant packaging material	1354:1396	an excellent antioxidant packaging material	1354:1396	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	9	26	contain	containing	1318:1327	arg2	PTE					1329:1331	PTE	1329:1331	PTE	1329:1331	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	8	27	theme	PTE	1213:1215	arg1	accretion					1200:1208	the accretion	1196:1208	the accretion of PTE	1196:1215	Notably, the accretion of PTE expressively enhanced the antioxidant properties of the SA-CP films.
34774594	1	28	theme	environmental	181:193	arg1	safety					195:200	its environmental safety	177:200	its environmental safety	177:200	A new type of film packaging made from natural polysaccharide materials, with its environmental safety and friendliness, is considered as a potential substitute for plastics.
34774594	0	29	theme	citrus	14:19	arg1	pectin					21:26	citrus pectin	14:26	citrus pectin	14:26	Alginate with citrus pectin and pterostilbene as healthy food packaging with antioxidant property.
34774594	3	30	theme	G	600:600	arg1	 > G					602:605	G" > G'	600:606	G" > G' at low frequency and weak gelation with G" < G' at high frequency	600:672	The rheological analysis displayed that all film-forming liquids performed no gelation behavior with G" > G' at low frequency and weak gelation with G" < G' at high frequency.
34774594	2	31	theme	composite	295:303	arg1	films					305:309	Novel polysaccharide composite films	274:309	Novel polysaccharide composite films based upon citrus pectin (CP) and sodium alginate (SA)	274:364	Novel polysaccharide composite films based upon citrus pectin (CP) and sodium alginate (SA) were successfully prepared and characterized, containing pterostilbene (PTE) at various concentrations (0.2, 0.4, 0.8, 1.6, 3.2 mM).
34774594	2	32	theme	various	446:452	arg1	3.2 mM					490:495	3.2 mM	490:495	3.2 mM	490:495	Novel polysaccharide composite films based upon citrus pectin (CP) and sodium alginate (SA) were successfully prepared and characterized, containing pterostilbene (PTE) at various concentrations (0.2, 0.4, 0.8, 1.6, 3.2 mM).
34774594	2	32	theme	various	446:452	arg1	concentrations					454:467	various concentrations	446:467	various concentrations (0.2, 0.4, 0.8, 1.6, 3.2 mM)	446:496	Novel polysaccharide composite films based upon citrus pectin (CP) and sodium alginate (SA) were successfully prepared and characterized, containing pterostilbene (PTE) at various concentrations (0.2, 0.4, 0.8, 1.6, 3.2 mM).
34774594	9	33	theme	packaging	1379:1387	arg1	films					1312:1316	the SA-CP composite films	1292:1316	the SA-CP composite films containing PTE	1292:1331	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	9	33	theme	packaging	1379:1387	arg1	material					1389:1396	an excellent antioxidant packaging material	1354:1396	an excellent antioxidant packaging material	1354:1396	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	5	34	theme	pure	906:909	arg1	films					917:921	the pure SA-CP films	902:921	the pure SA-CP films	902:921	Of note, the SA-CP films with PTE had better moisture resistance than that of the pure SA-CP films, which was related to the changes of its microstructure.
34774594	5	35	theme	SA-CP	911:915	arg1	films					917:921	the pure SA-CP films	902:921	the pure SA-CP films	902:921	Of note, the SA-CP films with PTE had better moisture resistance than that of the pure SA-CP films, which was related to the changes of its microstructure.
34774594	3	36	theme	film-forming	543:554	arg1	liquids					556:562	all film-forming liquids	539:562	all film-forming liquids	539:562	The rheological analysis displayed that all film-forming liquids performed no gelation behavior with G" > G' at low frequency and weak gelation with G" < G' at high frequency.
34774594	7	37	theme	calcium	1066:1072	arg1	cross-linking					1083:1095	calcium chloride cross-linking	1066:1095	calcium chloride cross-linking	1066:1095	After calcium chloride cross-linking, the water solubility of the films was reduced, while its thermal stability was improved.
34774594	0	38	theme	healthy	49:55	arg1	packaging					62:70	healthy food packaging	49:70	healthy food packaging with antioxidant property	49:96	Alginate with citrus pectin and pterostilbene as healthy food packaging with antioxidant property.
34774594	5	39	theme	microstructure	964:977	arg1	changes					949:955	the changes	945:955	the changes of its microstructure	945:977	Of note, the SA-CP films with PTE had better moisture resistance than that of the pure SA-CP films, which was related to the changes of its microstructure.
34774594	8	40	theme	SA-CP	1273:1277	arg1	films					1279:1283	the SA-CP films	1269:1283	the SA-CP films	1269:1283	Notably, the accretion of PTE expressively enhanced the antioxidant properties of the SA-CP films.
34774594	5	41	theme	better	862:867	arg1	resistance					878:887	better moisture resistance	862:887	better moisture resistance	862:887	Of note, the SA-CP films with PTE had better moisture resistance than that of the pure SA-CP films, which was related to the changes of its microstructure.
34774594	7	42	theme	water	1102:1106	arg1	solubility					1108:1117	the water solubility	1098:1117	the water solubility of the films	1098:1130	After calcium chloride cross-linking, the water solubility of the films was reduced, while its thermal stability was improved.
34774594	3	43	from	gelation	634:641	arg1	 > G					602:605	G" > G'	600:606	G" > G' at low frequency and weak gelation with G" < G' at high frequency	600:672	The rheological analysis displayed that all film-forming liquids performed no gelation behavior with G" > G' at low frequency and weak gelation with G" < G' at high frequency.
34774594	5	44	theme	moisture	869:876	arg1	resistance					878:887	better moisture resistance	862:887	better moisture resistance	862:887	Of note, the SA-CP films with PTE had better moisture resistance than that of the pure SA-CP films, which was related to the changes of its microstructure.
34774594	8	45	theme	films	1279:1283	arg1	properties					1255:1264	the antioxidant properties	1239:1264	the antioxidant properties of the SA-CP films	1239:1283	Notably, the accretion of PTE expressively enhanced the antioxidant properties of the SA-CP films.
34774594	9	46	used	utilized	1342:1349	arg2	material					1389:1396	an excellent antioxidant packaging material	1354:1396	an excellent antioxidant packaging material	1354:1396	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	9	46	used	utilized	1342:1349	arg2	films					1312:1316	the SA-CP composite films	1292:1316	the SA-CP composite films containing PTE	1292:1331	Thus, the SA-CP composite films containing PTE could be utilized as an excellent antioxidant packaging material.
34774594	6	47	theme	films	1011:1015	arg1	roughness					994:1002	The increased roughness	980:1002	The increased roughness of the films containing PTE	980:1030	The increased roughness of the films containing PTE was observed by microscope.
34774594	3	48	theme	low	611:613	arg1	frequency					615:623	low frequency	611:623	low frequency	611:623	The rheological analysis displayed that all film-forming liquids performed no gelation behavior with G" > G' at low frequency and weak gelation with G" < G' at high frequency.
34774594	4	49	theme	good	695:698	arg1	TS					718:719	TS	718:719	TS	718:719	The SA-CP films had good tensile strength (TS) and elongation at break (EB), while adding PTE as an antioxidant to the film reduced both the values.
34774594	4	49	theme	good	695:698	arg1	strength					708:715	good tensile strength	695:715	good tensile strength (TS)	695:720	The SA-CP films had good tensile strength (TS) and elongation at break (EB), while adding PTE as an antioxidant to the film reduced both the values.
34774594	0	50	with	Alginate	0:7	arg1	pterostilbene					32:44	pterostilbene	32:44	pterostilbene	32:44	Alginate with citrus pectin and pterostilbene as healthy food packaging with antioxidant property.
34774594	0	50	with	Alginate	0:7	arg1	pectin					21:26	citrus pectin	14:26	citrus pectin	14:26	Alginate with citrus pectin and pterostilbene as healthy food packaging with antioxidant property.
34774594	1	51	theme	film	113:116	arg1	packaging					118:126	film packaging	113:126	film packaging made from natural polysaccharide materials	113:169	A new type of film packaging made from natural polysaccharide materials, with its environmental safety and friendliness, is considered as a potential substitute for plastics.
34774594	6	52	theme	increased	984:992	arg1	roughness					994:1002	The increased roughness	980:1002	The increased roughness of the films containing PTE	980:1030	The increased roughness of the films containing PTE was observed by microscope.
34774594	3	53	theme	gelation	577:584	arg1	behavior					586:593	no gelation behavior	574:593	no gelation behavior	574:593	The rheological analysis displayed that all film-forming liquids performed no gelation behavior with G" > G' at low frequency and weak gelation with G" < G' at high frequency.
34774594	1	54	theme	packaging	118:126	arg1	potential					239:247	a potential	237:247	a potential substitute for plastics	237:271	A new type of film packaging made from natural polysaccharide materials, with its environmental safety and friendliness, is considered as a potential substitute for plastics.
34774594	1	54	theme	packaging	118:126	arg1	type					105:108	A new type	99:108	A new type	99:108	A new type of film packaging made from natural polysaccharide materials, with its environmental safety and friendliness, is considered as a potential substitute for plastics.
34774594	5	55	contain	had	858:860	arg1	films					843:847	the SA-CP films	833:847	the SA-CP films with PTE	833:856	Of note, the SA-CP films with PTE had better moisture resistance than that of the pure SA-CP films, which was related to the changes of its microstructure.
34774594	5	55	contain	had	858:860	arg2	resistance					878:887	better moisture resistance	862:887	better moisture resistance	862:887	Of note, the SA-CP films with PTE had better moisture resistance than that of the pure SA-CP films, which was related to the changes of its microstructure.
34774594	5	56	with	films	843:847	arg1	PTE					854:856	PTE	854:856	PTE	854:856	Of note, the SA-CP films with PTE had better moisture resistance than that of the pure SA-CP films, which was related to the changes of its microstructure.
34774594	1	57	dep	potential	239:247	arg1	substitute					249:258	substitute	249:258	substitute for plastics	249:271	A new type of film packaging made from natural polysaccharide materials, with its environmental safety and friendliness, is considered as a potential substitute for plastics.
34774594	7	58	theme	thermal	1155:1161	arg1	stability					1163:1171	its thermal stability	1151:1171	its thermal stability	1151:1171	After calcium chloride cross-linking, the water solubility of the films was reduced, while its thermal stability was improved.
34774594	7	59	theme	films	1126:1130	arg1	solubility					1108:1117	the water solubility	1098:1117	the water solubility of the films	1098:1130	After calcium chloride cross-linking, the water solubility of the films was reduced, while its thermal stability was improved.
34774594	7	60	theme	chloride	1074:1081	arg1	cross-linking					1083:1095	calcium chloride cross-linking	1066:1095	calcium chloride cross-linking	1066:1095	After calcium chloride cross-linking, the water solubility of the films was reduced, while its thermal stability was improved.
34774594	4	61	contain	had	691:693	arg2	elongation					726:735	elongation	726:735	elongation	726:735	The SA-CP films had good tensile strength (TS) and elongation at break (EB), while adding PTE as an antioxidant to the film reduced both the values.
34774594	4	61	contain	had	691:693	arg2	TS					718:719	TS	718:719	TS	718:719	The SA-CP films had good tensile strength (TS) and elongation at break (EB), while adding PTE as an antioxidant to the film reduced both the values.
34774594	4	61	contain	had	691:693	arg2	strength					708:715	good tensile strength	695:715	good tensile strength (TS)	695:720	The SA-CP films had good tensile strength (TS) and elongation at break (EB), while adding PTE as an antioxidant to the film reduced both the values.
34774594	4	61	contain	had	691:693	arg1	films					685:689	The SA-CP films	675:689	The SA-CP films	675:689	The SA-CP films had good tensile strength (TS) and elongation at break (EB), while adding PTE as an antioxidant to the film reduced both the values.
34774594	0	62	theme	food	57:60	arg1	packaging					62:70	healthy food packaging	49:70	healthy food packaging with antioxidant property	49:96	Alginate with citrus pectin and pterostilbene as healthy food packaging with antioxidant property.
34774594	3	63	theme	weak	629:632	arg1	gelation					634:641	weak gelation	629:641	weak gelation	629:641	The rheological analysis displayed that all film-forming liquids performed no gelation behavior with G" > G' at low frequency and weak gelation with G" < G' at high frequency.
34774594	4	64	theme	tensile	700:706	arg1	TS					718:719	TS	718:719	TS	718:719	The SA-CP films had good tensile strength (TS) and elongation at break (EB), while adding PTE as an antioxidant to the film reduced both the values.
34774594	4	64	theme	tensile	700:706	arg1	strength					708:715	good tensile strength	695:715	good tensile strength (TS)	695:720	The SA-CP films had good tensile strength (TS) and elongation at break (EB), while adding PTE as an antioxidant to the film reduced both the values.
34774594	2	65	theme	sodium	345:350	arg1	SA					362:363	SA	362:363	SA	362:363	Novel polysaccharide composite films based upon citrus pectin (CP) and sodium alginate (SA) were successfully prepared and characterized, containing pterostilbene (PTE) at various concentrations (0.2, 0.4, 0.8, 1.6, 3.2 mM).
34774594	2	65	theme	sodium	345:350	arg1	alginate					352:359	sodium alginate	345:359	sodium alginate (SA)	345:364	Novel polysaccharide composite films based upon citrus pectin (CP) and sodium alginate (SA) were successfully prepared and characterized, containing pterostilbene (PTE) at various concentrations (0.2, 0.4, 0.8, 1.6, 3.2 mM).
34774594	6	66	contain	containing	1017:1026	arg1	films					1011:1015	the films	1007:1015	the films containing PTE	1007:1030	The increased roughness of the films containing PTE was observed by microscope.
34774594	6	66	contain	containing	1017:1026	arg2	PTE					1028:1030	PTE	1028:1030	PTE	1028:1030	The increased roughness of the films containing PTE was observed by microscope.
33827016	0	0	theme	A	118:118	arg1	plasticizer					120:130	bisphenol A plasticizer	108:130	bisphenol A plasticizer	108:130	Cross-linked FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite for effective biosorption of bisphenol A plasticizer and basic dye from aqueous solution.
33827016	2	1	theme	solution	474:481	arg1	pH					483:484	solution pH	474:484	solution pH from 3 to 11	474:497	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	5	2	theme	hydrogel	1064:1071	arg1	composite					1073:1081	the newly synthesized hydrogel composite	1042:1081	the newly synthesized hydrogel composite	1042:1081	Results revealed the biosorption renewability for five cycles up to 80% of the newly synthesized hydrogel composite for the purification of industrial wastewater laden with emerging contaminants.
33827016	1	3	theme	seaweed	187:193	arg1	composite					227:235	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite	169:235	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2)	169:300	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	1	3	theme	seaweed	187:193	arg1	ALG					251:253	ECAC/MCM-41/ ALG	238:253	ECAC/MCM-41/ ALG	238:253	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	1	4	theme	%	293:293	arg1	CaCl2					295:299	2% CaCl2	292:299	2% CaCl2	292:299	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	1	4	theme	%	293:293	arg1	chloride					282:289	calcium chloride	274:289	calcium chloride (2% CaCl2)	274:300	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	0	5	theme	bisphenol	108:116	arg1	A					118:118	bisphenol A	108:118	bisphenol A plasticizer	108:130	Cross-linked FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite for effective biosorption of bisphenol A plasticizer and basic dye from aqueous solution.
33827016	1	6	theme	plasticizer	359:369	arg1	biosorption					326:336	the biosorption	322:336	the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye	322:393	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	1	7	theme	carbon/MCM-41/alginate	195:216	arg1	composite					227:235	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite	169:235	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2)	169:300	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	1	7	theme	carbon/MCM-41/alginate	195:216	arg1	ALG					251:253	ECAC/MCM-41/ ALG	238:253	ECAC/MCM-41/ ALG	238:253	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	3	8	theme	222.32	766:771	arg1	capacities					752:761	1 and 2 h with monolayer coverage capacities	718:761	1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g	718:787	The maximum BPA and BB uptake mechanisms were fast, which occurred within contact times of 1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g at 50 °C, respectively.
33827016	4	9	theme	Cyclic	813:818	arg1	behavior					843:850	Cyclic biosorption/desorption behavior	813:850	Cyclic biosorption/desorption behavior	813:850	Cyclic biosorption/desorption behavior was evaluated via an ethanol elution to evaluate the feasibility of the ECAC/MCM-41/ALG for long-term application.
33827016	5	10	with	laden	1129:1133	arg1	contaminants					1149:1160	emerging contaminants	1140:1160	emerging contaminants	1140:1160	Results revealed the biosorption renewability for five cycles up to 80% of the newly synthesized hydrogel composite for the purification of industrial wastewater laden with emerging contaminants.
33827016	4	11	theme	ECAC/MCM-41/ALG	924:938	arg1	feasibility					905:915	the feasibility	901:915	the feasibility of the ECAC/MCM-41/ALG for long-term application	901:964	Cyclic biosorption/desorption behavior was evaluated via an ethanol elution to evaluate the feasibility of the ECAC/MCM-41/ALG for long-term application.
33827016	0	12	theme	plasticizer	120:130	arg1	biosorption					93:103	effective biosorption	83:103	effective biosorption of bisphenol A plasticizer	83:130	Cross-linked FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite for effective biosorption of bisphenol A plasticizer and basic dye from aqueous solution.
33827016	3	13	theme	maximum	631:637	arg1	BPA					639:641	The maximum BPA	627:641	The maximum BPA	627:641	The maximum BPA and BB uptake mechanisms were fast, which occurred within contact times of 1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g at 50 °C, respectively.
33827016	3	13	theme	maximum	631:637	arg1	fast					673:676	fast	673:676	fast	673:676	The maximum BPA and BB uptake mechanisms were fast, which occurred within contact times of 1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g at 50 °C, respectively.
33827016	2	14	theme	reaction	551:558	arg1	time					560:563	reaction time	551:563	reaction time from 0 to 10 h	551:578	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	4	15	theme	long-term	944:952	arg1	application					954:964	long-term application	944:964	long-term application	944:964	Cyclic biosorption/desorption behavior was evaluated via an ethanol elution to evaluate the feasibility of the ECAC/MCM-41/ALG for long-term application.
33827016	2	16	from	300 mg/L	541:548	arg1	pH					483:484	solution pH	474:484	solution pH from 3 to 11	474:497	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	2	16	from	300 mg/L	541:548	arg1	concentration					516:528	initial sorbate concentration	500:528	initial sorbate concentration from 25 to 300 mg/L	500:548	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	2	16	from	300 mg/L	541:548	arg1	time					560:563	reaction time	551:563	reaction time from 0 to 10 h	551:578	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	2	16	from	300 mg/L	541:548	arg1	temperature					597:607	biosorption temperature	585:607	biosorption temperature	585:607	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	1	17	theme	blue	381:384	arg1	dye					391:393	basic blue (BB) dye	375:393	basic blue (BB) dye	375:393	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	0	18	link	Cross-linked	0:11	arg1	FeCl3-activated					13:27	Cross-linked FeCl3-activated	0:27	Cross-linked FeCl3-activated	0:27	Cross-linked FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite for effective biosorption of bisphenol A plasticizer and basic dye from aqueous solution.
33827016	1	19	theme	hydrogel	218:225	arg1	composite					227:235	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite	169:235	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2)	169:300	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	1	19	theme	hydrogel	218:225	arg1	ALG					251:253	ECAC/MCM-41/ ALG	238:253	ECAC/MCM-41/ ALG	238:253	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	0	20	theme	basic	136:140	arg1	dye					142:144	basic dye	136:144	basic dye	136:144	Cross-linked FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite for effective biosorption of bisphenol A plasticizer and basic dye from aqueous solution.
33827016	3	21	theme	uptake	650:655	arg1	mechanisms					657:666	BB uptake mechanisms	647:666	BB uptake mechanisms	647:666	The maximum BPA and BB uptake mechanisms were fast, which occurred within contact times of 1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g at 50 °C, respectively.
33827016	3	22	theme	contact	701:707	arg1	times					709:713	contact times	701:713	contact times of 1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g	701:787	The maximum BPA and BB uptake mechanisms were fast, which occurred within contact times of 1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g at 50 °C, respectively.
33827016	2	23	dep	10 h	575:578	arg1	to					572:573	to	572:573	to	572:573	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	2	24	dep	300 mg/L	541:548	arg1	to					538:539	to	538:539	to	538:539	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	5	25	theme	wastewater	1118:1127	arg1	laden					1129:1133	industrial wastewater laden	1107:1133	industrial wastewater laden with emerging contaminants	1107:1160	Results revealed the biosorption renewability for five cycles up to 80% of the newly synthesized hydrogel composite for the purification of industrial wastewater laden with emerging contaminants.
33827016	0	26	theme	Cross-linked	0:11	arg1	FeCl3-activated					13:27	Cross-linked FeCl3-activated	0:27	Cross-linked FeCl3-activated	0:27	Cross-linked FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite for effective biosorption of bisphenol A plasticizer and basic dye from aqueous solution.
33827016	2	27	theme	Biosorption	396:406	arg1	uptakes					408:414	Biosorption uptakes	396:414	Biosorption uptakes of BPA and BB	396:428	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	0	28	theme	carbon/MCM-41/alginate	37:58	arg1	composite					69:77	carbon/MCM-41/alginate hydrogel composite	37:77	carbon/MCM-41/alginate hydrogel composite for effective biosorption of bisphenol A plasticizer	37:130	Cross-linked FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite for effective biosorption of bisphenol A plasticizer and basic dye from aqueous solution.
33827016	5	29	theme	emerging	1140:1147	arg1	contaminants					1149:1160	emerging contaminants	1140:1160	emerging contaminants	1140:1160	Results revealed the biosorption renewability for five cycles up to 80% of the newly synthesized hydrogel composite for the purification of industrial wastewater laden with emerging contaminants.
33827016	0	30	theme	aqueous	151:157	arg1	solution					159:166	aqueous solution	151:166	aqueous solution	151:166	Cross-linked FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite for effective biosorption of bisphenol A plasticizer and basic dye from aqueous solution.
33827016	2	31	theme	biosorption	585:595	arg1	temperature					597:607	biosorption temperature	585:607	biosorption temperature	585:607	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	3	32	theme	capacities	752:761	arg1	times					709:713	contact times	701:713	contact times of 1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g	701:787	The maximum BPA and BB uptake mechanisms were fast, which occurred within contact times of 1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g at 50 °C, respectively.
33827016	2	33	theme	BB	427:428	arg1	uptakes					408:414	Biosorption uptakes	396:414	Biosorption uptakes of BPA and BB	396:428	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	4	34	theme	ethanol	873:879	arg1	elution					881:887	an ethanol elution	870:887	an ethanol elution	870:887	Cyclic biosorption/desorption behavior was evaluated via an ethanol elution to evaluate the feasibility of the ECAC/MCM-41/ALG for long-term application.
33827016	2	35	theme	BPA	419:421	arg1	uptakes					408:414	Biosorption uptakes	396:414	Biosorption uptakes of BPA and BB	396:428	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	2	36	theme	sorbate	508:514	arg1	concentration					516:528	initial sorbate concentration	500:528	initial sorbate concentration from 25 to 300 mg/L	500:548	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	1	37	theme	dye	391:393	arg1	biosorption					326:336	the biosorption	322:336	the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye	322:393	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	0	38	theme	hydrogel	60:67	arg1	composite					69:77	carbon/MCM-41/alginate hydrogel composite	37:77	carbon/MCM-41/alginate hydrogel composite for effective biosorption of bisphenol A plasticizer	37:130	Cross-linked FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite for effective biosorption of bisphenol A plasticizer and basic dye from aqueous solution.
33827016	2	39	from	10 h	575:578	arg1	pH					483:484	solution pH	474:484	solution pH from 3 to 11	474:497	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	2	39	from	10 h	575:578	arg1	concentration					516:528	initial sorbate concentration	500:528	initial sorbate concentration from 25 to 300 mg/L	500:548	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	2	39	from	10 h	575:578	arg1	time					560:563	reaction time	551:563	reaction time from 0 to 10 h	551:578	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	2	39	from	10 h	575:578	arg1	temperature					597:607	biosorption temperature	585:607	biosorption temperature	585:607	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	2	40	theme	initial	500:506	arg1	concentration					516:528	initial sorbate concentration	500:528	initial sorbate concentration from 25 to 300 mg/L	500:548	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	5	41	theme	laden	1129:1133	arg1	purification					1091:1102	the purification	1087:1102	the purification of industrial wastewater laden with emerging contaminants	1087:1160	Results revealed the biosorption renewability for five cycles up to 80% of the newly synthesized hydrogel composite for the purification of industrial wastewater laden with emerging contaminants.
33827016	0	42	theme	effective	83:91	arg1	biosorption					93:103	effective biosorption	83:103	effective biosorption of bisphenol A plasticizer	83:130	Cross-linked FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite for effective biosorption of bisphenol A plasticizer and basic dye from aqueous solution.
33827016	1	43	theme	bisphenol	341:349	arg1	BPA					354:356	BPA	354:356	BPA	354:356	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	1	43	theme	bisphenol	341:349	arg1	A					351:351	bisphenol A	341:351	bisphenol A (BPA) plasticizer	341:369	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	5	44	theme	biosorption	988:998	arg1	renewability					1000:1011	the biosorption renewability	984:1011	the biosorption renewability for five cycles up to 80% of the newly synthesized hydrogel composite for the purification of industrial wastewater laden with emerging contaminants	984:1160	Results revealed the biosorption renewability for five cycles up to 80% of the newly synthesized hydrogel composite for the purification of industrial wastewater laden with emerging contaminants.
33827016	5	45	theme	synthesized	1052:1062	arg1	composite					1073:1081	the newly synthesized hydrogel composite	1042:1081	the newly synthesized hydrogel composite	1042:1081	Results revealed the biosorption renewability for five cycles up to 80% of the newly synthesized hydrogel composite for the purification of industrial wastewater laden with emerging contaminants.
33827016	2	46	dep	11	496:497	arg1	to					493:494	to	493:494	to	493:494	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	1	47	theme	A	351:351	arg1	plasticizer					359:369	bisphenol A (BPA) plasticizer	341:369	bisphenol A (BPA) plasticizer	341:369	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	4	48	theme	biosorption/desorption	820:841	arg1	behavior					843:850	Cyclic biosorption/desorption behavior	813:850	Cyclic biosorption/desorption behavior	813:850	Cyclic biosorption/desorption behavior was evaluated via an ethanol elution to evaluate the feasibility of the ECAC/MCM-41/ALG for long-term application.
33827016	5	49	dep	%	1037:1037	arg1	up					1029:1030	up	1029:1030	up	1029:1030	Results revealed the biosorption renewability for five cycles up to 80% of the newly synthesized hydrogel composite for the purification of industrial wastewater laden with emerging contaminants.
33827016	2	50	dep	50 °C	620:624	arg1	to					617:618	to	617:618	to	617:618	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	1	51	dep	blue	381:384	arg1	BB					387:388	BB	387:388	BB	387:388	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	1	52	theme	calcium	274:280	arg1	CaCl2					295:299	2% CaCl2	292:299	2% CaCl2	292:299	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	1	52	theme	calcium	274:280	arg1	chloride					282:289	calcium chloride	274:289	calcium chloride (2% CaCl2)	274:300	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	3	53	theme	monolayer	733:741	arg1	coverage					743:750	monolayer coverage	733:750	monolayer coverage	733:750	The maximum BPA and BB uptake mechanisms were fast, which occurred within contact times of 1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g at 50 °C, respectively.
33827016	5	54	theme	industrial	1107:1116	arg1	laden					1129:1133	industrial wastewater laden	1107:1133	industrial wastewater laden with emerging contaminants	1107:1160	Results revealed the biosorption renewability for five cycles up to 80% of the newly synthesized hydrogel composite for the purification of industrial wastewater laden with emerging contaminants.
33827016	2	55	from	11	496:497	arg1	pH					483:484	solution pH	474:484	solution pH from 3 to 11	474:497	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	2	55	from	11	496:497	arg1	concentration					516:528	initial sorbate concentration	500:528	initial sorbate concentration from 25 to 300 mg/L	500:548	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	2	55	from	11	496:497	arg1	time					560:563	reaction time	551:563	reaction time from 0 to 10 h	551:578	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	2	55	from	11	496:497	arg1	temperature					597:607	biosorption temperature	585:607	biosorption temperature	585:607	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	3	56	theme	190.11 mg/g	777:787	arg1	capacities					752:761	1 and 2 h with monolayer coverage capacities	718:761	1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g	718:787	The maximum BPA and BB uptake mechanisms were fast, which occurred within contact times of 1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g at 50 °C, respectively.
33827016	2	57	theme	batch	450:454	arg1	mode					456:459	a batch mode	448:459	a batch mode	448:459	Biosorption uptakes of BPA and BB were performed in a batch mode with varying solution pH from 3 to 11, initial sorbate concentration from 25 to 300 mg/L, reaction time from 0 to 10 h, and biosorption temperature from 30 to 50 °C.
33827016	5	58	theme	composite	1073:1081	arg1	%					1037:1037	80%	1035:1037	80% of the newly synthesized hydrogel composite	1035:1081	Results revealed the biosorption renewability for five cycles up to 80% of the newly synthesized hydrogel composite for the purification of industrial wastewater laden with emerging contaminants.
33827016	5	58	theme	composite	1073:1081	arg1	composite					1073:1081	the newly synthesized hydrogel composite	1042:1081	the newly synthesized hydrogel composite	1042:1081	Results revealed the biosorption renewability for five cycles up to 80% of the newly synthesized hydrogel composite for the purification of industrial wastewater laden with emerging contaminants.
33827016	3	59	theme	2 h	724:726	arg1	capacities					752:761	1 and 2 h with monolayer coverage capacities	718:761	1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g	718:787	The maximum BPA and BB uptake mechanisms were fast, which occurred within contact times of 1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g at 50 °C, respectively.
33827016	3	60	theme	BB	647:648	arg1	mechanisms					657:666	BB uptake mechanisms	647:666	BB uptake mechanisms	647:666	The maximum BPA and BB uptake mechanisms were fast, which occurred within contact times of 1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g at 50 °C, respectively.
33827016	1	61	theme	FeCl3-activated	171:185	arg1	composite					227:235	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite	169:235	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2)	169:300	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	1	61	theme	FeCl3-activated	171:185	arg1	ALG					251:253	ECAC/MCM-41/ ALG	238:253	ECAC/MCM-41/ ALG	238:253	A FeCl3-activated seaweed carbon/MCM-41/alginate hydrogel composite (ECAC/MCM-41/ ALG) cross-linked with calcium chloride (2% CaCl2) was synthesized for the biosorption of bisphenol A (BPA) plasticizer and basic blue (BB) dye.
33827016	3	62	theme	1	718:718	arg1	capacities					752:761	1 and 2 h with monolayer coverage capacities	718:761	1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g	718:787	The maximum BPA and BB uptake mechanisms were fast, which occurred within contact times of 1 and 2 h with monolayer coverage capacities of 222.32 and 190.11 mg/g at 50 °C, respectively.
32384105	6	0	dep	30-week	745:751	arg1	November					761:768	November	761:768	November	761:768	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	6	1	theme	same	740:743	arg1	period					771:776	the same 30-week (May to November) period	736:776	the same 30-week (May to November) period in each year	736:789	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	15	2	theme	functional	2062:2071	arg1	differences					2073:2083	functional differences	2062:2083	functional differences in the bacterial populations present in the hindgut	2062:2135	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	5	3	theme	A	594:594	arg1	mares					601:605	23 Welsh Section A pony mares	577:605	23 Welsh Section A pony mares	577:605	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	6	4	theme	matter	932:937	arg1	intake					939:944	daily dry matter intake	922:944	daily dry matter intake	922:944	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	15	5	from	changes	1870:1876	arg1	bacteriome					1892:1901	the faecal bacteriome	1881:1901	the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies	1881:1983	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	6	6	theme	daily	922:926	arg1	intake					939:944	daily dry matter intake	922:944	daily dry matter intake	922:944	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	2	7	theme	other	276:280	arg1	species					282:288	other species	276:288	other species	276:288	Bacterial community composition is modified by age and diet in other species.
32384105	5	8	theme	5	705:705	arg1	Year					707:710	Year	707:710	Year	707:710	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	15	9	from	differences	2073:2083	arg1	populations					2102:2112	the bacterial populations	2088:2112	the bacterial populations present in the hindgut	2088:2135	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	8	10	theme	final	1159:1163	arg1	days					1167:1170	final 3 days	1159:1170	final 3 days hay	1159:1174	Faecal samples were collected for 11 days (final 3 days hay and 8 days hay + barley feeding).
32384105	5	11	from	12	657:658	arg1	total					663:667	total	663:667	total	663:667	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	2	12	theme	Bacterial	213:221	arg1	composition					233:243	Bacterial community composition	213:243	Bacterial community composition	213:243	Bacterial community composition is modified by age and diet in other species.
32384105	1	13	theme	dietary	194:200	arg1	nutrients					202:210	dietary nutrients	194:210	dietary nutrients	194:210	Bacteria residing in the gastrointestinal tract of mammals are crucial for the digestion of dietary nutrients.
32384105	8	14	dep	days	1153:1156	arg1	days					1167:1170	final 3 days	1159:1170	final 3 days hay	1159:1174	Faecal samples were collected for 11 days (final 3 days hay and 8 days hay + barley feeding).
32384105	8	14	dep	days	1153:1156	arg1	days					1182:1185	8 days	1180:1185	8 days hay + barley feeding	1180:1206	Faecal samples were collected for 11 days (final 3 days hay and 8 days hay + barley feeding).
32384105	15	15	from	transition	1923:1932	arg1	ponies					1978:1983	ponies	1978:1983	ponies	1978:1983	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	14	16	theme	VFA	1730:1732	arg1	concentrations					1734:1747	Faecal pH and VFA concentrations	1716:1747	Faecal pH and VFA concentrations	1716:1747	Faecal pH and VFA concentrations were modified by diet but considerable inter-individual variation was present.
32384105	11	17	theme	phyla	1468:1472	arg1	abundance					1474:1482	Candidatus Saccharibacteria and Firmicutes phyla abundance	1425:1482	Candidatus Saccharibacteria and Firmicutes phyla abundance	1425:1482	The dietary transition increased Candidatus Saccharibacteria and Firmicutes phyla abundance and reduced Fibrobactres abundance.
32384105	6	18	theme	5-week	828:833	arg1	period					835:840	a 5-week period	826:840	a 5-week period of study	826:849	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	1	19	theme	gastrointestinal	127:142	arg1	tract					144:148	the gastrointestinal tract	123:148	the gastrointestinal tract of mammals	123:159	Bacteria residing in the gastrointestinal tract of mammals are crucial for the digestion of dietary nutrients.
32384105	0	20	theme	gastrointestinal	40:55	arg1	bacteriome					57:66	the gastrointestinal bacteriome	36:66	the gastrointestinal bacteriome of ponies	36:76	Effect of age and the individual on the gastrointestinal bacteriome of ponies fed a high-starch diet.
32384105	2	21	mod	modified	248:255	arg3	age					260:262	age	260:262	age	260:262	Bacterial community composition is modified by age and diet in other species.
32384105	2	21	mod	modified	248:255	arg3	diet					268:271	diet	268:271	diet	268:271	Bacterial community composition is modified by age and diet in other species.
32384105	2	21	mod	modified	248:255	arg1	composition					233:243	Bacterial community composition	213:243	Bacterial community composition	213:243	Bacterial community composition is modified by age and diet in other species.
32384105	9	22	theme	Bacterial	1210:1218	arg1	communities					1220:1230	Bacterial communities	1210:1230	Bacterial communities	1210:1230	Bacterial communities were determined using Ion Torrent Sequencing of amplified V1-V2 hypervariable regions of 16S rRNA.
32384105	15	23	from	hindgut	2129:2135	arg1	present					2114:2120	present	2114:2120	present	2114:2120	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	4	24	theme	faecal	474:479	arg1	bacteriome					481:490	the faecal bacteriome	470:490	the faecal bacteriome of ponies transitioning from a hay-based diet to a high-starch diet	470:558	The current study assessed the impact of age on the faecal bacteriome of ponies transitioning from a hay-based diet to a high-starch diet.
32384105	3	25	dep	high-energy	351:361	arg1	high-starch					370:380	high-starch	370:380	high-starch	370:380	Although horses are adapted to consuming fibre-based diets, high-energy, often high-starch containing feeds are increasingly used.
32384105	13	26	theme	Bacterial	1627:1635	arg1	diversity					1637:1645	Bacterial diversity	1627:1645	Bacterial diversity	1627:1645	Bacterial diversity was reduced during dietary transition in Streptococcus 'responders'.
32384105	11	27	theme	Fibrobactres	1496:1507	arg1	abundance					1509:1517	Fibrobactres abundance	1496:1517	Fibrobactres abundance	1496:1517	The dietary transition increased Candidatus Saccharibacteria and Firmicutes phyla abundance and reduced Fibrobactres abundance.
32384105	15	28	theme	high-starch	1958:1968	arg1	diet					1970:1973	a high-starch diet	1956:1973	a high-starch diet	1956:1973	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	0	29	from	Effect	0:5	arg1	bacteriome					57:66	the gastrointestinal bacteriome	36:66	the gastrointestinal bacteriome of ponies	36:76	Effect of age and the individual on the gastrointestinal bacteriome of ponies fed a high-starch diet.
32384105	7	30	theme	final	971:975	arg1	week					977:980	the final week	967:980	the final week	967:980	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	15	31	theme	current	1832:1838	arg1	study					1840:1844	The current study	1828:1844	The current study	1828:1844	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	0	32	theme	high-starch	84:94	arg1	diet					96:99	a high-starch diet	82:99	a high-starch diet	82:99	Effect of age and the individual on the gastrointestinal bacteriome of ponies fed a high-starch diet.
32384105	9	33	theme	Torrent	1258:1264	arg1	Sequencing					1266:1275	Ion Torrent Sequencing	1254:1275	Ion Torrent Sequencing of amplified V1-V2 hypervariable regions of 16S rRNA	1254:1328	Bacterial communities were determined using Ion Torrent Sequencing of amplified V1-V2 hypervariable regions of 16S rRNA.
32384105	7	34	theme	3-day	1075:1079	arg1	transition					1081:1090	3-day transition	1075:1090	3-day transition	1075:1090	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	5	35	theme	Aged	670:673	arg1	years					680:684	≥19 years	676:684	≥19 years	676:684	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	10	36	theme	minimal	1341:1347	arg1	effect					1349:1354	a minimal effect	1339:1354	a minimal effect	1339:1354	Age had a minimal effect on the bacteriome response to diet.
32384105	13	37	from	transition	1674:1683	arg1	responders					1703:1712	responders	1703:1712	Streptococcus 'responders'	1688:1713	Bacterial diversity was reduced during dietary transition in Streptococcus 'responders'.
32384105	14	38	theme	pH	1723:1724	arg1	concentrations					1734:1747	Faecal pH and VFA concentrations	1716:1747	Faecal pH and VFA concentrations	1716:1747	Faecal pH and VFA concentrations were modified by diet but considerable inter-individual variation was present.
32384105	0	39	theme	age	10:12	arg1	Effect					0:5	Effect	0:5	Effect of age and the individual on the gastrointestinal bacteriome of ponies	0:76	Effect of age and the individual on the gastrointestinal bacteriome of ponies fed a high-starch diet.
32384105	15	40	theme	responses	2033:2041	arg1	nature					2015:2020	the individual nature	2000:2020	the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut	2000:2135	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	9	41	theme	V1-V2	1290:1294	arg1	regions					1310:1316	amplified V1-V2 hypervariable regions	1280:1316	amplified V1-V2 hypervariable regions of 16S rRNA	1280:1328	Bacterial communities were determined using Ion Torrent Sequencing of amplified V1-V2 hypervariable regions of 16S rRNA.
32384105	11	42	theme	dietary	1396:1402	arg1	transition					1404:1413	The dietary transition	1392:1413	The dietary transition	1392:1413	The dietary transition increased Candidatus Saccharibacteria and Firmicutes phyla abundance and reduced Fibrobactres abundance.
32384105	10	43	theme	bacteriome	1363:1372	arg1	response					1374:1381	the bacteriome response	1359:1381	the bacteriome response to diet	1359:1389	Age had a minimal effect on the bacteriome response to diet.
32384105	12	44	theme	individual	1607:1616	arg1	animals					1618:1624	individual animals	1607:1624	individual animals	1607:1624	At the genera level, Streptococcus abundance was increased but not consistently across individual animals.
32384105	9	45	theme	regions	1310:1316	arg1	Sequencing					1266:1275	Ion Torrent Sequencing	1254:1275	Ion Torrent Sequencing of amplified V1-V2 hypervariable regions of 16S rRNA	1254:1328	Bacterial communities were determined using Ion Torrent Sequencing of amplified V1-V2 hypervariable regions of 16S rRNA.
32384105	15	46	theme	individual	2004:2013	arg1	nature					2015:2020	the individual nature	2000:2020	the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut	2000:2135	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	9	47	theme	16S	1321:1323	arg1	rRNA					1325:1328	16S rRNA	1321:1328	16S rRNA	1321:1328	Bacterial communities were determined using Ion Torrent Sequencing of amplified V1-V2 hypervariable regions of 16S rRNA.
32384105	6	48	theme	body	909:912	arg1	mass					914:917	2% body mass	906:917	2% body mass as daily dry matter intake	906:944	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	6	49	from	period	771:776	arg1	year					786:789	each year	781:789	each year	781:789	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	11	50	theme	Saccharibacteria	1436:1451	arg1	abundance					1474:1482	Candidatus Saccharibacteria and Firmicutes phyla abundance	1425:1482	Candidatus Saccharibacteria and Firmicutes phyla abundance	1425:1482	The dietary transition increased Candidatus Saccharibacteria and Firmicutes phyla abundance and reduced Fibrobactres abundance.
32384105	15	51	attach	present	2114:2120	arg1	hindgut					2129:2135	the hindgut	2125:2135	the hindgut	2125:2135	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	15	51	attach	present	2114:2120	arg2	populations					2102:2112	the bacterial populations	2088:2112	the bacterial populations present in the hindgut	2088:2135	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	7	52	dep	diet	1069:1072	arg1	transition					1081:1090	3-day transition	1075:1090	3-day transition	1075:1090	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	7	52	dep	diet	1069:1072	arg1	days					1098:1101	5 days	1096:1101	5 days at maximum	1096:1112	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	1	53	theme	nutrients	202:210	arg1	digestion					181:189	the digestion	177:189	the digestion of dietary nutrients	177:210	Bacteria residing in the gastrointestinal tract of mammals are crucial for the digestion of dietary nutrients.
32384105	7	54	theme	micronized	1011:1020	arg1	mass					1005:1008	kg body mass	997:1008	kg body mass (micronized steam-flaked barley)	997:1041	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	7	54	theme	micronized	1011:1020	arg1	barley					1035:1040	micronized steam-flaked barley	1011:1040	micronized steam-flaked barley	1011:1040	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	5	55	dep	=	703:703	arg1	years					680:684	≥19 years	676:684	≥19 years	676:684	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	5	55	dep	=	703:703	arg1	years					638:642	5-15 years	633:642	5-15 years	633:642	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	5	55	dep	=	703:703	arg1	12					657:658	12	657:658	12	657:658	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	5	55	dep	=	703:703	arg1	n					687:687	n	687:687	n = 6 Year 1	687:698	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	5	55	dep	=	703:703	arg1	n					645:645	n	645:645	n = 6/year	645:654	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	5	55	dep	=	703:703	arg1	Controls					623:630	Controls	623:630	Controls	623:630	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	10	56	contain	had	1335:1337	arg1	Age					1331:1333	Age	1331:1333	Age	1331:1333	Age had a minimal effect on the bacteriome response to diet.
32384105	10	56	contain	had	1335:1337	arg2	effect					1349:1354	a minimal effect	1339:1354	a minimal effect	1339:1354	Age had a minimal effect on the bacteriome response to diet.
32384105	12	57	theme	genera	1527:1532	arg1	level					1534:1538	the genera level	1523:1538	the genera level	1523:1538	At the genera level, Streptococcus abundance was increased but not consistently across individual animals.
32384105	6	58	theme	30-week	745:751	arg1	period					771:776	the same 30-week (May to November) period	736:776	the same 30-week (May to November) period in each year	736:789	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	7	59	theme	kg	997:998	arg1	mass					1005:1008	kg body mass	997:1008	kg body mass (micronized steam-flaked barley)	997:1041	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	7	59	theme	kg	997:998	arg1	barley					1035:1040	micronized steam-flaked barley	1011:1040	micronized steam-flaked barley	1011:1040	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	5	60	theme	Section	586:592	arg1	mares					601:605	23 Welsh Section A pony mares	577:605	23 Welsh Section A pony mares	577:605	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	1	61	theme	mammals	153:159	arg1	tract					144:148	the gastrointestinal tract	123:148	the gastrointestinal tract of mammals	123:159	Bacteria residing in the gastrointestinal tract of mammals are crucial for the digestion of dietary nutrients.
32384105	5	62	theme	pony	596:599	arg1	mares					601:605	23 Welsh Section A pony mares	577:605	23 Welsh Section A pony mares	577:605	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	13	63	theme	Streptococcus	1688:1700	arg1	responders					1703:1712	responders	1703:1712	Streptococcus 'responders'	1688:1713	Bacterial diversity was reduced during dietary transition in Streptococcus 'responders'.
32384105	6	64	theme	dry	928:930	arg1	intake					939:944	daily dry matter intake	922:944	daily dry matter intake	922:944	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	4	65	from	impact	453:458	arg1	bacteriome					481:490	the faecal bacteriome	470:490	the faecal bacteriome of ponies transitioning from a hay-based diet to a high-starch diet	470:558	The current study assessed the impact of age on the faecal bacteriome of ponies transitioning from a hay-based diet to a high-starch diet.
32384105	6	66	dep	November	761:768	arg1	to					758:759	to	758:759	to	758:759	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	2	67	theme	community	223:231	arg1	composition					233:243	Bacterial community composition	213:243	Bacterial community composition	213:243	Bacterial community composition is modified by age and diet in other species.
32384105	14	68	theme	Faecal	1716:1721	arg1	concentrations					1734:1747	Faecal pH and VFA concentrations	1716:1747	Faecal pH and VFA concentrations	1716:1747	Faecal pH and VFA concentrations were modified by diet but considerable inter-individual variation was present.
32384105	14	69	theme	inter-individual	1788:1803	arg1	variation					1805:1813	considerable inter-individual variation	1775:1813	considerable inter-individual variation	1775:1813	Faecal pH and VFA concentrations were modified by diet but considerable inter-individual variation was present.
32384105	14	70	mod	modified	1754:1761	arg1	concentrations					1734:1747	Faecal pH and VFA concentrations	1716:1747	Faecal pH and VFA concentrations	1716:1747	Faecal pH and VFA concentrations were modified by diet but considerable inter-individual variation was present.
32384105	14	70	mod	modified	1754:1761	arg3	diet					1766:1769	diet	1766:1769	diet	1766:1769	Faecal pH and VFA concentrations were modified by diet but considerable inter-individual variation was present.
32384105	15	71	theme	compositional	1856:1868	arg1	changes					1870:1876	compositional changes	1856:1876	compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies	1856:1983	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	15	72	from	present	2114:2120	arg1	hindgut					2129:2135	the hindgut	2125:2135	the hindgut	2125:2135	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	4	73	theme	current	426:432	arg1	study					434:438	The current study	422:438	The current study	422:438	The current study assessed the impact of age on the faecal bacteriome of ponies transitioning from a hay-based diet to a high-starch diet.
32384105	13	74	theme	dietary	1666:1672	arg1	transition					1674:1683	dietary transition	1666:1683	dietary transition in Streptococcus 'responders'	1666:1713	Bacterial diversity was reduced during dietary transition in Streptococcus 'responders'.
32384105	7	75	theme	2g	983:984	arg1	starch					986:991	2g starch	983:991	2g starch per kg body mass (micronized steam-flaked barley)	983:1041	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	8	76	theme	barley	1193:1198	arg1	feeding					1200:1206	barley feeding	1193:1206	barley feeding	1193:1206	Faecal samples were collected for 11 days (final 3 days hay and 8 days hay + barley feeding).
32384105	15	77	from	fibre-based	1941:1951	arg1	transition					1923:1932	the transition	1919:1932	the transition from a fibre-based to a high-starch diet in ponies	1919:1983	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	11	78	theme	Firmicutes	1457:1466	arg1	abundance					1474:1482	Candidatus Saccharibacteria and Firmicutes phyla abundance	1425:1482	Candidatus Saccharibacteria and Firmicutes phyla abundance	1425:1482	The dietary transition increased Candidatus Saccharibacteria and Firmicutes phyla abundance and reduced Fibrobactres abundance.
32384105	0	79	theme	ponies	71:76	arg1	bacteriome					57:66	the gastrointestinal bacteriome	36:66	the gastrointestinal bacteriome of ponies	36:76	Effect of age and the individual on the gastrointestinal bacteriome of ponies fed a high-starch diet.
32384105	5	80	from	11	715:716	arg1	total					721:725	total	721:725	total	721:725	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	4	81	theme	ponies	495:500	arg1	bacteriome					481:490	the faecal bacteriome	470:490	the faecal bacteriome of ponies transitioning from a hay-based diet to a high-starch diet	470:558	The current study assessed the impact of age on the faecal bacteriome of ponies transitioning from a hay-based diet to a high-starch diet.
32384105	15	82	theme	faecal	1885:1890	arg1	bacteriome					1892:1901	the faecal bacteriome	1881:1901	the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies	1881:1983	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	4	83	theme	age	463:465	arg1	impact					453:458	the impact	449:458	the impact of age on the faecal bacteriome of ponies transitioning from a hay-based diet to a high-starch diet	449:558	The current study assessed the impact of age on the faecal bacteriome of ponies transitioning from a hay-based diet to a high-starch diet.
32384105	6	84	theme	2	906:906	arg1	%					907:907	%	907:907	%	907:907	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	5	85	theme	Welsh	580:584	arg1	mares					601:605	23 Welsh Section A pony mares	577:605	23 Welsh Section A pony mares	577:605	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	9	86	theme	Ion	1254:1256	arg1	Sequencing					1266:1275	Ion Torrent Sequencing	1254:1275	Ion Torrent Sequencing of amplified V1-V2 hypervariable regions of 16S rRNA	1254:1328	Bacterial communities were determined using Ion Torrent Sequencing of amplified V1-V2 hypervariable regions of 16S rRNA.
32384105	6	87	theme	same	881:884	arg1	hay					886:888	the same hay	877:888	the same hay	877:888	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	3	88	theme	fibre-based	332:342	arg1	diets					344:348	fibre-based diets	332:348	fibre-based diets	332:348	Although horses are adapted to consuming fibre-based diets, high-energy, often high-starch containing feeds are increasingly used.
32384105	8	89	dep	days	1182:1185	arg1	feeding					1200:1206	barley feeding	1193:1206	barley feeding	1193:1206	Faecal samples were collected for 11 days (final 3 days hay and 8 days hay + barley feeding).
32384105	8	89	dep	days	1182:1185	arg1	hay					1187:1189	hay	1187:1189	hay	1187:1189	Faecal samples were collected for 11 days (final 3 days hay and 8 days hay + barley feeding).
32384105	9	90	theme	amplified	1280:1288	arg1	regions					1310:1316	amplified V1-V2 hypervariable regions	1280:1316	amplified V1-V2 hypervariable regions of 16S rRNA	1280:1328	Bacterial communities were determined using Ion Torrent Sequencing of amplified V1-V2 hypervariable regions of 16S rRNA.
32384105	7	91	from	maximum	1106:1112	arg1	transition					1081:1090	3-day transition	1075:1090	3-day transition	1075:1090	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	7	91	from	maximum	1106:1112	arg1	days					1098:1101	5 days	1096:1101	5 days at maximum	1096:1112	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	4	92	theme	high-starch	543:553	arg1	diet					555:558	a high-starch diet	541:558	a high-starch diet	541:558	The current study assessed the impact of age on the faecal bacteriome of ponies transitioning from a hay-based diet to a high-starch diet.
32384105	0	93	theme	individual	22:31	arg1	Effect					0:5	Effect	0:5	Effect of age and the individual on the gastrointestinal bacteriome of ponies	0:76	Effect of age and the individual on the gastrointestinal bacteriome of ponies fed a high-starch diet.
32384105	9	94	theme	hypervariable	1296:1308	arg1	regions					1310:1316	amplified V1-V2 hypervariable regions	1280:1316	amplified V1-V2 hypervariable regions of 16S rRNA	1280:1328	Bacterial communities were determined using Ion Torrent Sequencing of amplified V1-V2 hypervariable regions of 16S rRNA.
32384105	6	95	theme	study	845:849	arg1	period					835:840	a 5-week period	826:840	a 5-week period of study	826:849	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	8	96	theme	Faecal	1116:1121	arg1	samples					1123:1129	Faecal samples	1116:1129	Faecal samples	1116:1129	Faecal samples were collected for 11 days (final 3 days hay and 8 days hay + barley feeding).
32384105	5	97	theme	=	689:689	arg1	n					687:687	n	687:687	n = 6 Year 1	687:698	Over two years, 23 Welsh Section A pony mares were evaluated (Controls, 5-15 years, n = 6/year, 12 in total; Aged, ≥19 years, n = 6 Year 1; n = 5 Year 2, 11 in total).
32384105	15	98	theme	dietary	2025:2031	arg1	responses					2033:2041	dietary responses	2025:2041	dietary responses	2025:2041	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	7	99	theme	steam-flaked	1022:1033	arg1	mass					1005:1008	kg body mass	997:1008	kg body mass (micronized steam-flaked barley)	997:1041	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	7	99	theme	steam-flaked	1022:1033	arg1	barley					1035:1040	micronized steam-flaked barley	1011:1040	micronized steam-flaked barley	1011:1040	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	4	100	theme	hay-based	523:531	arg1	diet					533:536	a hay-based diet	521:536	a hay-based diet	521:536	The current study assessed the impact of age on the faecal bacteriome of ponies transitioning from a hay-based diet to a high-starch diet.
32384105	6	101	dep	maintenance	893:903	arg1	mass					914:917	2% body mass	906:917	2% body mass as daily dry matter intake	906:944	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	9	102	theme	rRNA	1325:1328	arg1	regions					1310:1316	amplified V1-V2 hypervariable regions	1280:1316	amplified V1-V2 hypervariable regions of 16S rRNA	1280:1328	Bacterial communities were determined using Ion Torrent Sequencing of amplified V1-V2 hypervariable regions of 16S rRNA.
32384105	12	103	theme	Streptococcus	1541:1553	arg1	abundance					1555:1563	Streptococcus abundance	1541:1563	Streptococcus abundance	1541:1563	At the genera level, Streptococcus abundance was increased but not consistently across individual animals.
32384105	6	104	theme	%	907:907	arg1	mass					914:917	2% body mass	906:917	2% body mass as daily dry matter intake	906:944	Across the same 30-week (May to November) period in each year, animals were randomly assigned to a 5-week period of study and were individually fed the same hay to maintenance (2% body mass as daily dry matter intake) for 4-weeks.
32384105	14	105	theme	considerable	1775:1786	arg1	variation					1805:1813	considerable inter-individual variation	1775:1813	considerable inter-individual variation	1775:1813	Faecal pH and VFA concentrations were modified by diet but considerable inter-individual variation was present.
32384105	15	106	theme	present	2114:2120	arg1	populations					2102:2112	the bacterial populations	2088:2112	the bacterial populations present in the hindgut	2088:2135	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
32384105	7	107	theme	body	1000:1003	arg1	mass					1005:1008	kg body mass	997:1008	kg body mass (micronized steam-flaked barley)	997:1041	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	7	107	theme	body	1000:1003	arg1	barley					1035:1040	micronized steam-flaked barley	1011:1040	micronized steam-flaked barley	1011:1040	During the final week, 2g starch per kg body mass (micronized steam-flaked barley) was incorporated into the diet (3-day transition and 5 days at maximum).
32384105	15	108	theme	bacterial	2092:2100	arg1	populations					2102:2112	the bacterial populations	2088:2112	the bacterial populations present in the hindgut	2088:2135	The current study describes compositional changes in the faecal bacteriome associated with the transition from a fibre-based to a high-starch diet in ponies and emphasises the individual nature of dietary responses, which may reflect functional differences in the bacterial populations present in the hindgut.
33260859	5	0	theme	bioactive	888:896	arg1	compounds					898:906	bioactive compounds	888:906	bioactive compounds	888:906	The benefit of using MAE to improve the recovery of bioactive compounds was demonstrated and the carrageenan film with JPE showed a great strategy to add additives into food packaging.
33260859	1	1	theme	jaboticaba	171:180	arg1	JPE					196:198	JPE	196:198	JPE	196:198	This research investigated the bioactive potential of jaboticaba peel extract (JPE) and proposed an innovative material for food packaging based on carrageenan films incorporated with JPE.
33260859	1	1	theme	jaboticaba	171:180	arg1	extract					187:193	jaboticaba peel extract	171:193	jaboticaba peel extract (JPE)	171:199	This research investigated the bioactive potential of jaboticaba peel extract (JPE) and proposed an innovative material for food packaging based on carrageenan films incorporated with JPE.
33260859	0	2	theme	Food	101:104	arg1	Packaging					106:114	Active Food Packaging	94:114	Active Food Packaging	94:114	Carrageenan-Based Films Incorporated with Jaboticaba Peel Extract: An Innovative Material for Active Food Packaging.
33260859	0	3	theme	Active	94:99	arg1	Packaging					106:114	Active Food Packaging	94:114	Active Food Packaging	94:114	Carrageenan-Based Films Incorporated with Jaboticaba Peel Extract: An Innovative Material for Active Food Packaging.
33260859	1	4	theme	carrageenan	265:275	arg1	films					277:281	carrageenan films	265:281	carrageenan films incorporated with JPE	265:303	This research investigated the bioactive potential of jaboticaba peel extract (JPE) and proposed an innovative material for food packaging based on carrageenan films incorporated with JPE.
33260859	5	5	theme	great	968:972	arg1	strategy					974:981	a great strategy	966:981	a great strategy to add additives into food packaging	966:1018	The benefit of using MAE to improve the recovery of bioactive compounds was demonstrated and the carrageenan film with JPE showed a great strategy to add additives into food packaging.
33260859	1	6	theme	peel	182:185	arg1	JPE					196:198	JPE	196:198	JPE	196:198	This research investigated the bioactive potential of jaboticaba peel extract (JPE) and proposed an innovative material for food packaging based on carrageenan films incorporated with JPE.
33260859	1	6	theme	peel	182:185	arg1	extract					187:193	jaboticaba peel extract	171:193	jaboticaba peel extract (JPE)	171:199	This research investigated the bioactive potential of jaboticaba peel extract (JPE) and proposed an innovative material for food packaging based on carrageenan films incorporated with JPE.
33260859	0	7	theme	Peel	53:56	arg1	Extract					58:64	Jaboticaba Peel Extract	42:64	Jaboticaba Peel Extract	42:64	Carrageenan-Based Films Incorporated with Jaboticaba Peel Extract: An Innovative Material for Active Food Packaging.
33260859	4	8	theme	solubility	761:770	arg1	results					750:756	The results	746:756	The results of solubility and mechanical properties	746:796	The results of solubility and mechanical properties did not show significant differences.
33260859	1	9	theme	extract	187:193	arg1	potential					158:166	the bioactive potential	144:166	the bioactive potential of jaboticaba peel extract (JPE)	144:199	This research investigated the bioactive potential of jaboticaba peel extract (JPE) and proposed an innovative material for food packaging based on carrageenan films incorporated with JPE.
33260859	3	10	theme	light	719:723	arg1	barrier					725:731	the light barrier	715:731	the light barrier of the film	715:743	The carrageenan film incorporated with JPE was manageable, homogeneous and the presence of JPE into film increased the thickness and improved the light barrier of the film.
33260859	0	11	theme	Innovative	70:79	arg1	Material					81:88	An Innovative Material	67:88	An Innovative Material for Active Food Packaging	67:114	Carrageenan-Based Films Incorporated with Jaboticaba Peel Extract: An Innovative Material for Active Food Packaging.
33260859	5	12	theme	carrageenan	933:943	arg1	film					945:948	the carrageenan film	929:948	the carrageenan film with JPE	929:957	The benefit of using MAE to improve the recovery of bioactive compounds was demonstrated and the carrageenan film with JPE showed a great strategy to add additives into food packaging.
33260859	0	13	theme	Carrageenan-Based	0:16	arg1	Films					18:22	Carrageenan-Based Films	0:22	Carrageenan-Based Films Incorporated with Jaboticaba Peel Extract	0:64	Carrageenan-Based Films Incorporated with Jaboticaba Peel Extract: An Innovative Material for Active Food Packaging.
33260859	0	14	dep	Material	81:88	arg1	Films					18:22	Carrageenan-Based Films	0:22	Carrageenan-Based Films Incorporated with Jaboticaba Peel Extract	0:64	Carrageenan-Based Films Incorporated with Jaboticaba Peel Extract: An Innovative Material for Active Food Packaging.
33260859	5	15	theme	food	1005:1008	arg1	packaging					1010:1018	food packaging	1005:1018	food packaging	1005:1018	The benefit of using MAE to improve the recovery of bioactive compounds was demonstrated and the carrageenan film with JPE showed a great strategy to add additives into food packaging.
33260859	2	16	theme	optimized	432:440	arg1	conditions					442:451	the optimized conditions	428:451	the optimized conditions	428:451	The extract was obtained through microwave assisted extraction (MAE) according to central composite rotational design and the optimized conditions showed a combined antimicrobial and antioxidant actions when the extraction process is accomplished at 80 °C and 1 min.
33260859	5	17	theme	compounds	898:906	arg1	recovery					876:883	the recovery	872:883	the recovery of bioactive compounds	872:906	The benefit of using MAE to improve the recovery of bioactive compounds was demonstrated and the carrageenan film with JPE showed a great strategy to add additives into food packaging.
33260859	3	18	dep	manageable	620:629	arg1	manageable					620:629	manageable	620:629	manageable	620:629	The carrageenan film incorporated with JPE was manageable, homogeneous and the presence of JPE into film increased the thickness and improved the light barrier of the film.
33260859	3	18	dep	manageable	620:629	arg1	film					589:592	The carrageenan film	573:592	The carrageenan film incorporated with JPE	573:614	The carrageenan film incorporated with JPE was manageable, homogeneous and the presence of JPE into film increased the thickness and improved the light barrier of the film.
33260859	3	18	dep	manageable	620:629	arg1	homogeneous					632:642	homogeneous	632:642	homogeneous	632:642	The carrageenan film incorporated with JPE was manageable, homogeneous and the presence of JPE into film increased the thickness and improved the light barrier of the film.
33260859	2	19	theme	antioxidant	489:499	arg1	actions					501:507	antioxidant actions	489:507	antioxidant actions	489:507	The extract was obtained through microwave assisted extraction (MAE) according to central composite rotational design and the optimized conditions showed a combined antimicrobial and antioxidant actions when the extraction process is accomplished at 80 °C and 1 min.
33260859	3	20	theme	film	740:743	arg1	barrier					725:731	the light barrier	715:731	the light barrier of the film	715:743	The carrageenan film incorporated with JPE was manageable, homogeneous and the presence of JPE into film increased the thickness and improved the light barrier of the film.
33260859	4	21	theme	significant	811:821	arg1	differences					823:833	significant differences	811:833	significant differences	811:833	The results of solubility and mechanical properties did not show significant differences.
33260859	2	22	theme	composite	396:404	arg1	design					417:422	central composite rotational design	388:422	central composite rotational design	388:422	The extract was obtained through microwave assisted extraction (MAE) according to central composite rotational design and the optimized conditions showed a combined antimicrobial and antioxidant actions when the extraction process is accomplished at 80 °C and 1 min.
33260859	0	23	theme	Jaboticaba	42:51	arg1	Extract					58:64	Jaboticaba Peel Extract	42:64	Jaboticaba Peel Extract	42:64	Carrageenan-Based Films Incorporated with Jaboticaba Peel Extract: An Innovative Material for Active Food Packaging.
33260859	2	24	theme	rotational	406:415	arg1	design					417:422	central composite rotational design	388:422	central composite rotational design	388:422	The extract was obtained through microwave assisted extraction (MAE) according to central composite rotational design and the optimized conditions showed a combined antimicrobial and antioxidant actions when the extraction process is accomplished at 80 °C and 1 min.
33260859	2	25	theme	assisted	349:356	arg1	MAE					370:372	MAE	370:372	MAE	370:372	The extract was obtained through microwave assisted extraction (MAE) according to central composite rotational design and the optimized conditions showed a combined antimicrobial and antioxidant actions when the extraction process is accomplished at 80 °C and 1 min.
33260859	2	25	theme	assisted	349:356	arg1	extraction					358:367	microwave assisted extraction	339:367	microwave assisted extraction (MAE) according to central composite rotational design	339:422	The extract was obtained through microwave assisted extraction (MAE) according to central composite rotational design and the optimized conditions showed a combined antimicrobial and antioxidant actions when the extraction process is accomplished at 80 °C and 1 min.
33260859	2	26	theme	combined	462:469	arg1	antimicrobial					471:483	a combined antimicrobial	460:483	a combined antimicrobial	460:483	The extract was obtained through microwave assisted extraction (MAE) according to central composite rotational design and the optimized conditions showed a combined antimicrobial and antioxidant actions when the extraction process is accomplished at 80 °C and 1 min.
33260859	2	27	theme	microwave	339:347	arg1	MAE					370:372	MAE	370:372	MAE	370:372	The extract was obtained through microwave assisted extraction (MAE) according to central composite rotational design and the optimized conditions showed a combined antimicrobial and antioxidant actions when the extraction process is accomplished at 80 °C and 1 min.
33260859	2	27	theme	microwave	339:347	arg1	extraction					358:367	microwave assisted extraction	339:367	microwave assisted extraction (MAE) according to central composite rotational design	339:422	The extract was obtained through microwave assisted extraction (MAE) according to central composite rotational design and the optimized conditions showed a combined antimicrobial and antioxidant actions when the extraction process is accomplished at 80 °C and 1 min.
33260859	4	28	theme	properties	787:796	arg1	results					750:756	The results	746:756	The results of solubility and mechanical properties	746:796	The results of solubility and mechanical properties did not show significant differences.
33260859	1	29	theme	innovative	217:226	arg1	material					228:235	an innovative material	214:235	an innovative material for food packaging based on carrageenan films incorporated with JPE	214:303	This research investigated the bioactive potential of jaboticaba peel extract (JPE) and proposed an innovative material for food packaging based on carrageenan films incorporated with JPE.
33260859	3	30	theme	JPE	664:666	arg1	presence					652:659	the presence	648:659	the presence of JPE into film	648:676	The carrageenan film incorporated with JPE was manageable, homogeneous and the presence of JPE into film increased the thickness and improved the light barrier of the film.
33260859	4	31	theme	mechanical	776:785	arg1	properties					787:796	mechanical properties	776:796	mechanical properties	776:796	The results of solubility and mechanical properties did not show significant differences.
33260859	2	32	theme	extraction	518:527	arg1	process					529:535	the extraction process	514:535	the extraction process	514:535	The extract was obtained through microwave assisted extraction (MAE) according to central composite rotational design and the optimized conditions showed a combined antimicrobial and antioxidant actions when the extraction process is accomplished at 80 °C and 1 min.
33260859	1	33	theme	bioactive	148:156	arg1	potential					158:166	the bioactive potential	144:166	the bioactive potential of jaboticaba peel extract (JPE)	144:199	This research investigated the bioactive potential of jaboticaba peel extract (JPE) and proposed an innovative material for food packaging based on carrageenan films incorporated with JPE.
33260859	2	34	theme	central	388:394	arg1	design					417:422	central composite rotational design	388:422	central composite rotational design	388:422	The extract was obtained through microwave assisted extraction (MAE) according to central composite rotational design and the optimized conditions showed a combined antimicrobial and antioxidant actions when the extraction process is accomplished at 80 °C and 1 min.
33260859	5	35	with	film	945:948	arg1	JPE					955:957	JPE	955:957	JPE	955:957	The benefit of using MAE to improve the recovery of bioactive compounds was demonstrated and the carrageenan film with JPE showed a great strategy to add additives into food packaging.
33260859	3	36	theme	carrageenan	577:587	arg1	manageable					620:629	manageable	620:629	manageable	620:629	The carrageenan film incorporated with JPE was manageable, homogeneous and the presence of JPE into film increased the thickness and improved the light barrier of the film.
33260859	3	36	theme	carrageenan	577:587	arg1	film					589:592	The carrageenan film	573:592	The carrageenan film incorporated with JPE	573:614	The carrageenan film incorporated with JPE was manageable, homogeneous and the presence of JPE into film increased the thickness and improved the light barrier of the film.
33260859	3	36	theme	carrageenan	577:587	arg1	homogeneous					632:642	homogeneous	632:642	homogeneous	632:642	The carrageenan film incorporated with JPE was manageable, homogeneous and the presence of JPE into film increased the thickness and improved the light barrier of the film.
33260859	1	37	theme	food	241:244	arg1	packaging					246:254	food packaging	241:254	food packaging based on carrageenan films incorporated with JPE	241:303	This research investigated the bioactive potential of jaboticaba peel extract (JPE) and proposed an innovative material for food packaging based on carrageenan films incorporated with JPE.
34857750	0	0	theme	steviol	92:98	arg1	glycosides					100:109	palatable steviol glycosides	82:109	palatable steviol glycosides	82:109	Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides.
34857750	5	1	from	substrate	767:775	arg1	modes					786:790	three modes	780:790	three modes	780:790	The enzyme's ability to bind steviol glycoside substrate in three modes underlies its flexibility to catalyze β (1-2) glucosylation in two distinct orientations as well as β (1-6) glucosylation.
34857750	1	2	from	rebaudiana	190:199	arg1	extracts					169:176	extracts	169:176	extracts from Stevia rebaudiana	169:199	Steviol glycosides are the intensely sweet components of extracts from Stevia rebaudiana.
34857750	1	2	from	rebaudiana	190:199	arg1	components					155:164	the intensely sweet components	135:164	the intensely sweet components of extracts from Stevia rebaudiana	135:199	Steviol glycosides are the intensely sweet components of extracts from Stevia rebaudiana.
34857750	1	2	from	rebaudiana	190:199	arg1	glycosides					120:129	Steviol glycosides	112:129	Steviol glycosides	112:129	Steviol glycosides are the intensely sweet components of extracts from Stevia rebaudiana.
34857750	1	3	theme	extracts	169:176	arg1	components					155:164	the intensely sweet components	135:164	the intensely sweet components of extracts from Stevia rebaudiana	135:199	Steviol glycosides are the intensely sweet components of extracts from Stevia rebaudiana.
34857750	1	3	theme	extracts	169:176	arg1	glycosides					120:129	Steviol glycosides	112:129	Steviol glycosides	112:129	Steviol glycosides are the intensely sweet components of extracts from Stevia rebaudiana.
34857750	0	4	theme	palatable	82:90	arg1	glycosides					100:109	palatable steviol glycosides	82:109	palatable steviol glycosides	82:109	Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides.
34857750	3	5	theme	specific	503:510	arg1	glucosylation					520:532	specific β (1-2) glucosylation	503:532	specific β (1-2) glucosylation in Stevia	503:542	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	6	from	glucosylation	520:532	arg1	Stevia					537:542	Stevia	537:542	Stevia	537:542	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	7	theme	glucosylation	520:532	arg1	levels					493:498	low levels	489:498	low levels of specific β (1-2) glucosylation in Stevia	489:542	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	4	8	theme	Oryza	650:654	arg1	sativa					656:661	Oryza sativa	650:661	Oryza sativa	650:661	Here, we report the biochemical and structural characterization of OsUGT91C1, a glycosyltransferase from Oryza sativa, which is efficient at catalyzing β (1-2) glucosylation.
34857750	4	9	theme	biochemical	565:575	arg1	characterization					592:607	the biochemical and structural characterization	561:607	the biochemical and structural characterization of OsUGT91C1, a glycosyltransferase from Oryza sativa, which is efficient at catalyzing β (1-2) glucosylation	561:717	Here, we report the biochemical and structural characterization of OsUGT91C1, a glycosyltransferase from Oryza sativa, which is efficient at catalyzing β (1-2) glucosylation.
34857750	0	10	theme	glycosides	100:109	arg1	production					68:77	the production	64:77	the production of palatable steviol glycosides	64:109	Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides.
34857750	1	11	from	components	155:164	arg1	rebaudiana					190:199	Stevia rebaudiana	183:199	Stevia rebaudiana	183:199	Steviol glycosides are the intensely sweet components of extracts from Stevia rebaudiana.
34857750	5	12	theme	β	830:830	arg1	glucosylation					838:850	β (1-2) glucosylation	830:850	β (1-2) glucosylation	830:850	The enzyme's ability to bind steviol glycoside substrate in three modes underlies its flexibility to catalyze β (1-2) glucosylation in two distinct orientations as well as β (1-6) glucosylation.
34857750	3	13	theme	steviol	368:374	arg1	M					401:401	Reb M	397:401	Reb M	397:401	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	13	theme	steviol	368:374	arg1	glycosides					376:385	the most desirable steviol glycosides	349:385	the most desirable steviol glycosides Reb D and Reb M	349:401	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	13	theme	steviol	368:374	arg1	Reb					387:389	Reb	387:389	Reb	387:389	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	4	14	theme	β	697:697	arg1	glucosylation					705:717	β (1-2) glucosylation	697:717	β (1-2) glucosylation	697:717	Here, we report the biochemical and structural characterization of OsUGT91C1, a glycosyltransferase from Oryza sativa, which is efficient at catalyzing β (1-2) glucosylation.
34857750	4	15	from	sativa	656:661	arg1	OsUGT91C1					612:620	OsUGT91C1	612:620	OsUGT91C1	612:620	Here, we report the biochemical and structural characterization of OsUGT91C1, a glycosyltransferase from Oryza sativa, which is efficient at catalyzing β (1-2) glucosylation.
34857750	4	15	from	sativa	656:661	arg1	glycosyltransferase					625:643	a glycosyltransferase	623:643	a glycosyltransferase from Oryza sativa, which is efficient at catalyzing β (1-2) glucosylation	623:717	Here, we report the biochemical and structural characterization of OsUGT91C1, a glycosyltransferase from Oryza sativa, which is efficient at catalyzing β (1-2) glucosylation.
34857750	1	16	theme	Stevia	183:188	arg1	rebaudiana					190:199	Stevia rebaudiana	183:199	Stevia rebaudiana	183:199	Steviol glycosides are the intensely sweet components of extracts from Stevia rebaudiana.
34857750	5	17	theme	distinct	859:866	arg1	orientations					868:879	two distinct orientations	855:879	two distinct orientations as well as β (1-6) glucosylation	855:912	The enzyme's ability to bind steviol glycoside substrate in three modes underlies its flexibility to catalyze β (1-2) glucosylation in two distinct orientations as well as β (1-6) glucosylation.
34857750	0	18	theme	OsUGT91C1	50:58	arg1	flexibility					10:20	Catalytic flexibility	0:20	Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides	0:109	Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides.
34857750	6	19	theme	promising	1068:1076	arg1	catalyst					1078:1085	a promising catalyst	1066:1085	a promising catalyst for the industrial production of naturally rare but palatable steviol glycosides	1066:1166	Guided by the structural insights, we engineer this enzyme to enhance the desirable β (1-2) glucosylation, eliminate β (1-6) glucosylation, and obtain a promising catalyst for the industrial production of naturally rare but palatable steviol glycosides.
34857750	5	20	theme	β	892:892	arg1	glucosylation					900:912	β (1-6) glucosylation	892:912	two distinct orientations as well as β (1-6) glucosylation	855:912	The enzyme's ability to bind steviol glycoside substrate in three modes underlies its flexibility to catalyze β (1-2) glucosylation in two distinct orientations as well as β (1-6) glucosylation.
34857750	0	21	theme	Catalytic	0:8	arg1	flexibility					10:20	Catalytic flexibility	0:20	Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides	0:109	Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides.
34857750	6	22	theme	glycosides	1157:1166	arg1	production					1106:1115	the industrial production	1091:1115	the industrial production of naturally rare but palatable steviol glycosides	1091:1166	Guided by the structural insights, we engineer this enzyme to enhance the desirable β (1-2) glucosylation, eliminate β (1-6) glucosylation, and obtain a promising catalyst for the industrial production of naturally rare but palatable steviol glycosides.
34857750	6	23	theme	β	999:999	arg1	glucosylation					1007:1019	the desirable β (1-2) glucosylation	985:1019	the desirable β (1-2) glucosylation	985:1019	Guided by the structural insights, we engineer this enzyme to enhance the desirable β (1-2) glucosylation, eliminate β (1-6) glucosylation, and obtain a promising catalyst for the industrial production of naturally rare but palatable steviol glycosides.
34857750	0	24	theme	rice	25:28	arg1	OsUGT91C1					50:58	rice glycosyltransferase OsUGT91C1	25:58	rice glycosyltransferase OsUGT91C1	25:58	Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides.
34857750	3	25	from	levels	493:498	arg1	Stevia					537:542	Stevia	537:542	Stevia	537:542	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	1	26	theme	Steviol	112:118	arg1	components					155:164	the intensely sweet components	135:164	the intensely sweet components of extracts from Stevia rebaudiana	135:199	Steviol glycosides are the intensely sweet components of extracts from Stevia rebaudiana.
34857750	1	26	theme	Steviol	112:118	arg1	glycosides					120:129	Steviol glycosides	112:129	Steviol glycosides	112:129	Steviol glycosides are the intensely sweet components of extracts from Stevia rebaudiana.
34857750	3	27	theme	trace	468:472	arg1	amounts					474:480	trace amounts	468:480	trace amounts due to low levels of specific β (1-2) glucosylation in Stevia	468:542	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	28	theme	Reb	397:399	arg1	M					401:401	Reb M	397:401	Reb M	397:401	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	28	theme	Reb	397:399	arg1	glycosides					376:385	the most desirable steviol glycosides	349:385	the most desirable steviol glycosides Reb D and Reb M	349:401	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	2	29	theme	low-calorie	317:327	arg1	sweetener					329:337	a low-calorie sweetener	315:337	a low-calorie sweetener	315:337	These molecules comprise an invariant steviol aglycone decorated with variable glycans and could widely serve as a low-calorie sweetener.
34857750	2	29	theme	low-calorie	317:327	arg1	molecules					208:216	These molecules	202:216	These molecules	202:216	These molecules comprise an invariant steviol aglycone decorated with variable glycans and could widely serve as a low-calorie sweetener.
34857750	4	30	theme	OsUGT91C1	612:620	arg1	characterization					592:607	the biochemical and structural characterization	561:607	the biochemical and structural characterization of OsUGT91C1, a glycosyltransferase from Oryza sativa, which is efficient at catalyzing β (1-2) glucosylation	561:717	Here, we report the biochemical and structural characterization of OsUGT91C1, a glycosyltransferase from Oryza sativa, which is efficient at catalyzing β (1-2) glucosylation.
34857750	3	31	theme	unpleasant	414:423	arg1	aftertaste					425:434	unpleasant aftertaste	414:434	unpleasant aftertaste	414:434	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	6	32	theme	steviol	1149:1155	arg1	glycosides					1157:1166	naturally rare but palatable steviol glycosides	1120:1166	naturally rare but palatable steviol glycosides	1120:1166	Guided by the structural insights, we engineer this enzyme to enhance the desirable β (1-2) glucosylation, eliminate β (1-6) glucosylation, and obtain a promising catalyst for the industrial production of naturally rare but palatable steviol glycosides.
34857750	0	33	theme	glycosyltransferase	30:48	arg1	OsUGT91C1					50:58	rice glycosyltransferase OsUGT91C1	25:58	rice glycosyltransferase OsUGT91C1	25:58	Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides.
34857750	3	34	theme	aftertaste	425:434	arg1	devoid					404:409	devoid	404:409	devoid	404:409	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	6	35	theme	palatable	1139:1147	arg1	glycosides					1157:1166	naturally rare but palatable steviol glycosides	1120:1166	naturally rare but palatable steviol glycosides	1120:1166	Guided by the structural insights, we engineer this enzyme to enhance the desirable β (1-2) glucosylation, eliminate β (1-6) glucosylation, and obtain a promising catalyst for the industrial production of naturally rare but palatable steviol glycosides.
34857750	3	36	theme	devoid	404:409	arg1	M					401:401	Reb M	397:401	Reb M	397:401	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	36	theme	devoid	404:409	arg1	glycosides					376:385	the most desirable steviol glycosides	349:385	the most desirable steviol glycosides Reb D and Reb M	349:401	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	36	theme	devoid	404:409	arg1	Reb					387:389	Reb	387:389	Reb	387:389	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	6	37	theme	β	1032:1032	arg1	glucosylation					1040:1052	β (1-6) glucosylation	1032:1052	β (1-6) glucosylation	1032:1052	Guided by the structural insights, we engineer this enzyme to enhance the desirable β (1-2) glucosylation, eliminate β (1-6) glucosylation, and obtain a promising catalyst for the industrial production of naturally rare but palatable steviol glycosides.
34857750	3	38	theme	low	489:491	arg1	levels					493:498	low levels	489:498	low levels of specific β (1-2) glucosylation in Stevia	489:542	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	39	dep	glycosides	376:385	arg1	M					401:401	Reb M	397:401	Reb M	397:401	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	39	dep	glycosides	376:385	arg1	glycosides					376:385	the most desirable steviol glycosides	349:385	the most desirable steviol glycosides Reb D and Reb M	349:401	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	39	dep	glycosides	376:385	arg1	Reb					387:389	Reb	387:389	Reb	387:389	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	2	40	theme	invariant	230:238	arg1	aglycone					248:255	an invariant steviol aglycone	227:255	an invariant steviol aglycone decorated with variable glycans	227:287	These molecules comprise an invariant steviol aglycone decorated with variable glycans and could widely serve as a low-calorie sweetener.
34857750	2	41	theme	steviol	240:246	arg1	aglycone					248:255	an invariant steviol aglycone	227:255	an invariant steviol aglycone decorated with variable glycans	227:287	These molecules comprise an invariant steviol aglycone decorated with variable glycans and could widely serve as a low-calorie sweetener.
34857750	3	42	from	Stevia	537:542	arg1	levels					493:498	low levels	489:498	low levels of specific β (1-2) glucosylation in Stevia	489:542	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	6	43	theme	industrial	1095:1104	arg1	production					1106:1115	the industrial production	1091:1115	the industrial production of naturally rare but palatable steviol glycosides	1091:1166	Guided by the structural insights, we engineer this enzyme to enhance the desirable β (1-2) glucosylation, eliminate β (1-6) glucosylation, and obtain a promising catalyst for the industrial production of naturally rare but palatable steviol glycosides.
34857750	3	44	dep	Reb	387:389	arg1	D					391:391	Reb D	387:391	Reb D	387:391	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	5	45	theme	glycoside	757:765	arg1	substrate					767:775	steviol glycoside substrate	749:775	steviol glycoside substrate in three modes	749:790	The enzyme's ability to bind steviol glycoside substrate in three modes underlies its flexibility to catalyze β (1-2) glucosylation in two distinct orientations as well as β (1-6) glucosylation.
34857750	5	46	theme	steviol	749:755	arg1	substrate					767:775	steviol glycoside substrate	749:775	steviol glycoside substrate in three modes	749:790	The enzyme's ability to bind steviol glycoside substrate in three modes underlies its flexibility to catalyze β (1-2) glucosylation in two distinct orientations as well as β (1-6) glucosylation.
34857750	3	47	theme	due	482:484	arg1	amounts					474:480	trace amounts	468:480	trace amounts due to low levels of specific β (1-2) glucosylation in Stevia	468:542	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	5	48	theme	1-6	895:897	arg1	glucosylation					900:912	β (1-6) glucosylation	892:912	two distinct orientations as well as β (1-6) glucosylation	855:912	The enzyme's ability to bind steviol glycoside substrate in three modes underlies its flexibility to catalyze β (1-2) glucosylation in two distinct orientations as well as β (1-6) glucosylation.
34857750	4	49	theme	structural	581:590	arg1	characterization					592:607	the biochemical and structural characterization	561:607	the biochemical and structural characterization of OsUGT91C1, a glycosyltransferase from Oryza sativa, which is efficient at catalyzing β (1-2) glucosylation	561:717	Here, we report the biochemical and structural characterization of OsUGT91C1, a glycosyltransferase from Oryza sativa, which is efficient at catalyzing β (1-2) glucosylation.
34857750	6	50	theme	structural	929:938	arg1	insights					940:947	the structural insights	925:947	the structural insights	925:947	Guided by the structural insights, we engineer this enzyme to enhance the desirable β (1-2) glucosylation, eliminate β (1-6) glucosylation, and obtain a promising catalyst for the industrial production of naturally rare but palatable steviol glycosides.
34857750	1	51	theme	sweet	149:153	arg1	components					155:164	the intensely sweet components	135:164	the intensely sweet components of extracts from Stevia rebaudiana	135:199	Steviol glycosides are the intensely sweet components of extracts from Stevia rebaudiana.
34857750	1	51	theme	sweet	149:153	arg1	glycosides					120:129	Steviol glycosides	112:129	Steviol glycosides	112:129	Steviol glycosides are the intensely sweet components of extracts from Stevia rebaudiana.
34857750	6	52	theme	desirable	989:997	arg1	glucosylation					1007:1019	the desirable β (1-2) glucosylation	985:1019	the desirable β (1-2) glucosylation	985:1019	Guided by the structural insights, we engineer this enzyme to enhance the desirable β (1-2) glucosylation, eliminate β (1-6) glucosylation, and obtain a promising catalyst for the industrial production of naturally rare but palatable steviol glycosides.
34857750	3	53	theme	β	512:512	arg1	glucosylation					520:532	specific β (1-2) glucosylation	503:532	specific β (1-2) glucosylation in Stevia	503:542	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	54	theme	desirable	358:366	arg1	M					401:401	Reb M	397:401	Reb M	397:401	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	54	theme	desirable	358:366	arg1	glycosides					376:385	the most desirable steviol glycosides	349:385	the most desirable steviol glycosides Reb D and Reb M	349:401	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	3	54	theme	desirable	358:366	arg1	Reb					387:389	Reb	387:389	Reb	387:389	However, the most desirable steviol glycosides Reb D and Reb M, devoid of unpleasant aftertaste, are naturally produced only in trace amounts due to low levels of specific β (1-2) glucosylation in Stevia.
34857750	2	55	theme	variable	272:279	arg1	glycans					281:287	variable glycans	272:287	variable glycans	272:287	These molecules comprise an invariant steviol aglycone decorated with variable glycans and could widely serve as a low-calorie sweetener.
34857750	6	56	theme	rare	1130:1133	arg1	glycosides					1157:1166	naturally rare but palatable steviol glycosides	1120:1166	naturally rare but palatable steviol glycosides	1120:1166	Guided by the structural insights, we engineer this enzyme to enhance the desirable β (1-2) glucosylation, eliminate β (1-6) glucosylation, and obtain a promising catalyst for the industrial production of naturally rare but palatable steviol glycosides.
32586219	6	0	contain	containing	755:764	arg2	MI-BC-com					787:795	MI-BC-com	787:795	MI-BC-com	787:795	The composite membrane containing MI-BC and quercetin (MI-BC-com) delayed and sustained drug release more effectively than the composite membrane containing NI-BC and quercetin (NI-BC-com).
32586219	6	0	contain	containing	755:764	arg2	quercetin					776:784	quercetin	776:784	quercetin	776:784	The composite membrane containing MI-BC and quercetin (MI-BC-com) delayed and sustained drug release more effectively than the composite membrane containing NI-BC and quercetin (NI-BC-com).
32586219	6	0	contain	containing	755:764	arg2	MI-BC					766:770	MI-BC	766:770	MI-BC	766:770	The composite membrane containing MI-BC and quercetin (MI-BC-com) delayed and sustained drug release more effectively than the composite membrane containing NI-BC and quercetin (NI-BC-com).
32586219	6	0	contain	containing	755:764	arg1	membrane					746:753	The composite membrane	732:753	The composite membrane containing MI-BC and quercetin (MI-BC-com)	732:796	The composite membrane containing MI-BC and quercetin (MI-BC-com) delayed and sustained drug release more effectively than the composite membrane containing NI-BC and quercetin (NI-BC-com).
32586219	9	1	theme	simple	1136:1141	arg1	method					1143:1148	the relatively simple method	1121:1148	the relatively simple method of preparing the drug delivery system without using synthetic MIP	1121:1214	Due to the relatively simple method of preparing the drug delivery system without using synthetic MIP, the application of MI-BC may be of great interest in medicine and pharmaceutics.
32586219	3	2	theme	imprinted	489:497	arg1	BC					499:500	molecularly imprinted BC	477:500	molecularly imprinted BC (MI-BC)	477:508	The phase inversion method was successfully used to prepare molecularly imprinted BC (MI-BC).
32586219	3	2	theme	imprinted	489:497	arg1	MI-BC					503:507	MI-BC	503:507	MI-BC	503:507	The phase inversion method was successfully used to prepare molecularly imprinted BC (MI-BC).
32586219	4	3	theme	release	565:571	arg1	behavior					573:580	controlled drug release behavior	549:580	controlled drug release behavior	549:580	The molecular recognition ability and controlled drug release behavior of MI-BC were then evaluated.
32586219	7	4	theme	quercetin	941:949	arg1	times					969:973	quercetin approximately two times	941:973	quercetin approximately two times	941:973	MI-BC-com released quercetin approximately two times more slowly than NI-BC-com did at the final hour of the drug release study.
32586219	2	5	theme	materials	330:338	arg1	use					313:315	the use	309:315	the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule	309:414	In the present study, the molecular imprinting was directly performed on BC to avoid the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule.
32586219	4	6	theme	drug	560:563	arg1	behavior					573:580	controlled drug release behavior	549:580	controlled drug release behavior	549:580	The molecular recognition ability and controlled drug release behavior of MI-BC were then evaluated.
32586219	5	7	theme	non-imprinted	702:714	arg1	NI-BC					720:724	NI-BC	720:724	NI-BC	720:724	MI-BC was found to have approximately 1.6 times higher ability to bind quercetin than the non-imprinted BC (NI-BC) did.
32586219	5	7	theme	non-imprinted	702:714	arg1	BC					716:717	the non-imprinted BC	698:717	the non-imprinted BC (NI-BC)	698:725	MI-BC was found to have approximately 1.6 times higher ability to bind quercetin than the non-imprinted BC (NI-BC) did.
32586219	9	8	theme	great	1252:1256	arg1	interest					1258:1265	great interest	1252:1265	great interest	1252:1265	Due to the relatively simple method of preparing the drug delivery system without using synthetic MIP, the application of MI-BC may be of great interest in medicine and pharmaceutics.
32586219	1	9	with	combination	133:143	arg1	MIP					181:183	MIP	181:183	MIP	181:183	Bacterial cellulose (BC) has been used in the combination with molecularly imprinted polymer (MIP) for controlled-release drug delivery.
32586219	1	9	with	combination	133:143	arg1	polymer					172:178	molecularly imprinted polymer	150:178	molecularly imprinted polymer (MIP) for controlled-release drug delivery	150:221	Bacterial cellulose (BC) has been used in the combination with molecularly imprinted polymer (MIP) for controlled-release drug delivery.
32586219	5	10	theme	1.6	650:652	arg1	times					654:658	times	654:658	times	654:658	MI-BC was found to have approximately 1.6 times higher ability to bind quercetin than the non-imprinted BC (NI-BC) did.
32586219	8	11	theme	Higuchi	1099:1105	arg1	model					1107:1111	the Higuchi model	1095:1111	the Higuchi model	1095:1111	The mechanism of quercetin release followed the Higuchi model.
32586219	5	12	dep	times	654:658	arg1	higher					660:665	higher	660:665	higher	660:665	MI-BC was found to have approximately 1.6 times higher ability to bind quercetin than the non-imprinted BC (NI-BC) did.
32586219	6	13	theme	composite	859:867	arg1	membrane					869:876	the composite membrane	855:876	the composite membrane containing NI-BC and quercetin (NI-BC-com)	855:919	The composite membrane containing MI-BC and quercetin (MI-BC-com) delayed and sustained drug release more effectively than the composite membrane containing NI-BC and quercetin (NI-BC-com).
32586219	1	14	theme	Bacterial	87:95	arg1	BC					108:109	BC	108:109	BC	108:109	Bacterial cellulose (BC) has been used in the combination with molecularly imprinted polymer (MIP) for controlled-release drug delivery.
32586219	1	14	theme	Bacterial	87:95	arg1	cellulose					97:105	Bacterial cellulose	87:105	Bacterial cellulose (BC)	87:110	Bacterial cellulose (BC) has been used in the combination with molecularly imprinted polymer (MIP) for controlled-release drug delivery.
32586219	6	15	contain	containing	878:887	arg2	quercetin					899:907	quercetin	899:907	quercetin (NI-BC-com)	899:919	The composite membrane containing MI-BC and quercetin (MI-BC-com) delayed and sustained drug release more effectively than the composite membrane containing NI-BC and quercetin (NI-BC-com).
32586219	6	15	contain	containing	878:887	arg2	NI-BC					889:893	NI-BC	889:893	NI-BC	889:893	The composite membrane containing MI-BC and quercetin (MI-BC-com) delayed and sustained drug release more effectively than the composite membrane containing NI-BC and quercetin (NI-BC-com).
32586219	6	15	contain	containing	878:887	arg1	membrane					869:876	the composite membrane	855:876	the composite membrane containing NI-BC and quercetin (NI-BC-com)	855:919	The composite membrane containing MI-BC and quercetin (MI-BC-com) delayed and sustained drug release more effectively than the composite membrane containing NI-BC and quercetin (NI-BC-com).
32586219	6	15	contain	containing	878:887	arg2	NI-BC-com					910:918	NI-BC-com	910:918	NI-BC-com	910:918	The composite membrane containing MI-BC and quercetin (MI-BC-com) delayed and sustained drug release more effectively than the composite membrane containing NI-BC and quercetin (NI-BC-com).
32586219	9	16	theme	drug	1167:1170	arg1	system					1181:1186	the drug delivery system	1163:1186	the drug delivery system	1163:1186	Due to the relatively simple method of preparing the drug delivery system without using synthetic MIP, the application of MI-BC may be of great interest in medicine and pharmaceutics.
32586219	3	17	theme	phase	421:425	arg1	method					437:442	The phase inversion method	417:442	The phase inversion method	417:442	The phase inversion method was successfully used to prepare molecularly imprinted BC (MI-BC).
32586219	9	18	theme	delivery	1172:1179	arg1	system					1181:1186	the drug delivery system	1163:1186	the drug delivery system	1163:1186	Due to the relatively simple method of preparing the drug delivery system without using synthetic MIP, the application of MI-BC may be of great interest in medicine and pharmaceutics.
32586219	2	19	theme	quercetin	365:373	arg1	molecule					407:414	the template molecule	394:414	the template molecule	394:414	In the present study, the molecular imprinting was directly performed on BC to avoid the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule.
32586219	2	19	theme	quercetin	365:373	arg1	sustained-release					344:360	sustained-release	344:360	sustained-release	344:360	In the present study, the molecular imprinting was directly performed on BC to avoid the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule.
32586219	9	20	from	interest	1258:1265	arg1	pharmaceutics					1283:1295	pharmaceutics	1283:1295	pharmaceutics	1283:1295	Due to the relatively simple method of preparing the drug delivery system without using synthetic MIP, the application of MI-BC may be of great interest in medicine and pharmaceutics.
32586219	9	20	from	interest	1258:1265	arg1	medicine					1270:1277	medicine	1270:1277	medicine	1270:1277	Due to the relatively simple method of preparing the drug delivery system without using synthetic MIP, the application of MI-BC may be of great interest in medicine and pharmaceutics.
32586219	4	21	theme	recognition	525:535	arg1	ability					537:543	The molecular recognition ability	511:543	The molecular recognition ability	511:543	The molecular recognition ability and controlled drug release behavior of MI-BC were then evaluated.
32586219	7	22	theme	release	1036:1042	arg1	study					1044:1048	the drug release study	1027:1048	the drug release study	1027:1048	MI-BC-com released quercetin approximately two times more slowly than NI-BC-com did at the final hour of the drug release study.
32586219	6	23	theme	composite	736:744	arg1	membrane					746:753	The composite membrane	732:753	The composite membrane containing MI-BC and quercetin (MI-BC-com)	732:796	The composite membrane containing MI-BC and quercetin (MI-BC-com) delayed and sustained drug release more effectively than the composite membrane containing NI-BC and quercetin (NI-BC-com).
32586219	1	24	used	used	121:124	arg2	BC					108:109	BC	108:109	BC	108:109	Bacterial cellulose (BC) has been used in the combination with molecularly imprinted polymer (MIP) for controlled-release drug delivery.
32586219	1	24	used	used	121:124	arg2	cellulose					97:105	Bacterial cellulose	87:105	Bacterial cellulose (BC)	87:110	Bacterial cellulose (BC) has been used in the combination with molecularly imprinted polymer (MIP) for controlled-release drug delivery.
32586219	2	25	theme	template	398:405	arg1	molecule					407:414	the template molecule	394:414	the template molecule	394:414	In the present study, the molecular imprinting was directly performed on BC to avoid the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule.
32586219	2	25	theme	template	398:405	arg1	sustained-release					344:360	sustained-release	344:360	sustained-release	344:360	In the present study, the molecular imprinting was directly performed on BC to avoid the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule.
32586219	0	26	theme	bacterial	22:30	arg1	cellulose					32:40	bacterial cellulose	22:40	bacterial cellulose	22:40	Molecularly imprinted bacterial cellulose for sustained-release delivery of quercetin.
32586219	4	27	theme	controlled	549:558	arg1	behavior					573:580	controlled drug release behavior	549:580	controlled drug release behavior	549:580	The molecular recognition ability and controlled drug release behavior of MI-BC were then evaluated.
32586219	7	28	theme	study	1044:1048	arg1	hour					1019:1022	the final hour	1009:1022	the final hour of the drug release study	1009:1048	MI-BC-com released quercetin approximately two times more slowly than NI-BC-com did at the final hour of the drug release study.
32586219	9	29	theme	synthetic	1202:1210	arg1	MIP					1212:1214	synthetic MIP	1202:1214	synthetic MIP	1202:1214	Due to the relatively simple method of preparing the drug delivery system without using synthetic MIP, the application of MI-BC may be of great interest in medicine and pharmaceutics.
32586219	1	30	theme	imprinted	162:170	arg1	MIP					181:183	MIP	181:183	MIP	181:183	Bacterial cellulose (BC) has been used in the combination with molecularly imprinted polymer (MIP) for controlled-release drug delivery.
32586219	1	30	theme	imprinted	162:170	arg1	polymer					172:178	molecularly imprinted polymer	150:178	molecularly imprinted polymer (MIP) for controlled-release drug delivery	150:221	Bacterial cellulose (BC) has been used in the combination with molecularly imprinted polymer (MIP) for controlled-release drug delivery.
32586219	1	31	theme	controlled-release	190:207	arg1	delivery					214:221	controlled-release drug delivery	190:221	controlled-release drug delivery	190:221	Bacterial cellulose (BC) has been used in the combination with molecularly imprinted polymer (MIP) for controlled-release drug delivery.
32586219	0	32	theme	sustained-release	46:62	arg1	delivery					64:71	sustained-release delivery	46:71	sustained-release delivery of quercetin	46:84	Molecularly imprinted bacterial cellulose for sustained-release delivery of quercetin.
32586219	3	33	theme	inversion	427:435	arg1	method					437:442	The phase inversion method	417:442	The phase inversion method	417:442	The phase inversion method was successfully used to prepare molecularly imprinted BC (MI-BC).
32586219	2	34	theme	present	231:237	arg1	study					239:243	the present study	227:243	the present study	227:243	In the present study, the molecular imprinting was directly performed on BC to avoid the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule.
32586219	1	35	theme	drug	209:212	arg1	delivery					214:221	controlled-release drug delivery	190:221	controlled-release drug delivery	190:221	Bacterial cellulose (BC) has been used in the combination with molecularly imprinted polymer (MIP) for controlled-release drug delivery.
32586219	7	36	theme	drug	1031:1034	arg1	study					1044:1048	the drug release study	1027:1048	the drug release study	1027:1048	MI-BC-com released quercetin approximately two times more slowly than NI-BC-com did at the final hour of the drug release study.
32586219	3	37	used	used	461:464	arg2	method					437:442	The phase inversion method	417:442	The phase inversion method	417:442	The phase inversion method was successfully used to prepare molecularly imprinted BC (MI-BC).
32586219	2	38	used	used	386:389	arg2	molecule					407:414	the template molecule	394:414	the template molecule	394:414	In the present study, the molecular imprinting was directly performed on BC to avoid the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule.
32586219	2	38	used	used	386:389	arg2	sustained-release					344:360	sustained-release	344:360	sustained-release	344:360	In the present study, the molecular imprinting was directly performed on BC to avoid the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule.
32586219	5	39	dep	ability	667:673	arg1	times					654:658	times	654:658	times	654:658	MI-BC was found to have approximately 1.6 times higher ability to bind quercetin than the non-imprinted BC (NI-BC) did.
32586219	5	39	dep	ability	667:673	arg1	bind					678:681	bind	678:681	to bind quercetin	675:691	MI-BC was found to have approximately 1.6 times higher ability to bind quercetin than the non-imprinted BC (NI-BC) did.
32586219	8	40	theme	release	1078:1084	arg1	mechanism					1055:1063	The mechanism	1051:1063	The mechanism of quercetin release	1051:1084	The mechanism of quercetin release followed the Higuchi model.
32586219	6	41	theme	drug	820:823	arg1	release					825:831	drug release	820:831	drug release	820:831	The composite membrane containing MI-BC and quercetin (MI-BC-com) delayed and sustained drug release more effectively than the composite membrane containing NI-BC and quercetin (NI-BC-com).
32586219	2	42	theme	synthetic	320:328	arg1	materials					330:338	synthetic materials	320:338	synthetic materials	320:338	In the present study, the molecular imprinting was directly performed on BC to avoid the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule.
32586219	4	43	theme	molecular	515:523	arg1	ability					537:543	The molecular recognition ability	511:543	The molecular recognition ability	511:543	The molecular recognition ability and controlled drug release behavior of MI-BC were then evaluated.
32586219	8	44	theme	quercetin	1068:1076	arg1	release					1078:1084	quercetin release	1068:1084	quercetin release	1068:1084	The mechanism of quercetin release followed the Higuchi model.
32586219	2	45	theme	molecular	250:258	arg1	imprinting					260:269	the molecular imprinting	246:269	the molecular imprinting	246:269	In the present study, the molecular imprinting was directly performed on BC to avoid the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule.
32586219	7	46	theme	final	1013:1017	arg1	hour					1019:1022	the final hour	1009:1022	the final hour of the drug release study	1009:1048	MI-BC-com released quercetin approximately two times more slowly than NI-BC-com did at the final hour of the drug release study.
32586219	4	47	theme	MI-BC	585:589	arg1	behavior					573:580	controlled drug release behavior	549:580	controlled drug release behavior	549:580	The molecular recognition ability and controlled drug release behavior of MI-BC were then evaluated.
32586219	4	47	theme	MI-BC	585:589	arg1	ability					537:543	The molecular recognition ability	511:543	The molecular recognition ability	511:543	The molecular recognition ability and controlled drug release behavior of MI-BC were then evaluated.
32586219	9	48	theme	MI-BC	1236:1240	arg1	application					1221:1231	the application	1217:1231	the application of MI-BC	1217:1240	Due to the relatively simple method of preparing the drug delivery system without using synthetic MIP, the application of MI-BC may be of great interest in medicine and pharmaceutics.
32586219	5	49	contain	have	631:634	arg1	MI-BC					612:616	MI-BC	612:616	MI-BC	612:616	MI-BC was found to have approximately 1.6 times higher ability to bind quercetin than the non-imprinted BC (NI-BC) did.
32586219	5	49	contain	have	631:634	arg2	ability					667:673	approximately 1.6 times higher ability	636:673	approximately 1.6 times higher ability to bind quercetin	636:691	MI-BC was found to have approximately 1.6 times higher ability to bind quercetin than the non-imprinted BC (NI-BC) did.
32586219	0	50	theme	quercetin	76:84	arg1	delivery					64:71	sustained-release delivery	46:71	sustained-release delivery of quercetin	46:84	Molecularly imprinted bacterial cellulose for sustained-release delivery of quercetin.
33709392	7	0	theme	80	1352:1353	arg1	%					1354:1354	%	1354:1354	%	1354:1354	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	5	1	from	challenges	1098:1107	arg1	samples					1139:1145	food samples	1134:1145	food samples	1134:1145	These procedures included measures to prevent enzyme activity and microbial growth, which represent two of the most relevant challenges in sugar extraction from food samples.
33709392	5	1	from	challenges	1098:1107	arg1	extraction					1118:1127	sugar extraction	1112:1127	sugar extraction from food samples	1112:1145	These procedures included measures to prevent enzyme activity and microbial growth, which represent two of the most relevant challenges in sugar extraction from food samples.
33709392	7	2	theme	high-protein	1542:1553	arg1	ingredients					1555:1565	plant-based high-protein ingredients	1530:1565	plant-based high-protein ingredients	1530:1565	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	5	3	from	samples	1139:1145	arg1	challenges					1098:1107	the most relevant challenges	1080:1107	the most relevant challenges in sugar extraction from food samples	1080:1145	These procedures included measures to prevent enzyme activity and microbial growth, which represent two of the most relevant challenges in sugar extraction from food samples.
33709392	5	3	from	samples	1139:1145	arg1	extraction					1118:1127	sugar extraction	1112:1127	sugar extraction from food samples	1112:1145	These procedures included measures to prevent enzyme activity and microbial growth, which represent two of the most relevant challenges in sugar extraction from food samples.
33709392	1	4	theme	high-protein	291:302	arg1	ingredients					304:314	plant-based high-protein ingredients	279:314	plant-based high-protein ingredients a necessity	279:326	BACKGROUND The increasing importance of plant-based proteins in the food sector makes a reliable compositional analysis of plant-based high-protein ingredients a necessity.
33709392	3	5	theme	chromatographic	610:624	arg1	separation					626:635	subsequent high-performance liquid chromatographic separation	575:635	subsequent high-performance liquid chromatographic separation	575:635	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates have been discussed controversially regarding a range of complications that can potentially lead to inaccurate sugar determination.
33709392	7	6	theme	sugar	1507:1511	arg1	determination					1513:1525	sugar determination	1507:1525	sugar determination in plant-based high-protein ingredients	1507:1565	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	3	7	theme	carbohydrates	671:683	arg1	separation					626:635	subsequent high-performance liquid chromatographic separation	575:635	subsequent high-performance liquid chromatographic separation	575:635	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates have been discussed controversially regarding a range of complications that can potentially lead to inaccurate sugar determination.
33709392	3	7	theme	carbohydrates	671:683	arg1	quantification					641:654	quantification	641:654	quantification	641:654	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates have been discussed controversially regarding a range of complications that can potentially lead to inaccurate sugar determination.
33709392	8	8	theme	sucrose	1793:1799	arg1	levels					1783:1788	their levels	1777:1788	their levels of sucrose, maltose, glucose and fructose	1777:1830	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	1	9	theme	proteins	208:215	arg1	importance					182:191	The increasing importance	167:191	The increasing importance of plant-based proteins in the food sector	167:234	BACKGROUND The increasing importance of plant-based proteins in the food sector makes a reliable compositional analysis of plant-based high-protein ingredients a necessity.
33709392	6	10	theme	fructose	1221:1228	arg1	sum					1185:1187	sum	1185:1187	sum of sucrose/maltose, glucose and fructose	1185:1228	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	8	11	theme	maltose	1802:1808	arg1	levels					1783:1788	their levels	1777:1788	their levels of sucrose, maltose, glucose and fructose	1777:1830	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	6	12	theme	sucrose/maltose	1192:1206	arg1	sum					1185:1187	sum	1185:1187	sum of sucrose/maltose, glucose and fructose	1185:1228	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	0	13	theme	high-protein	130:141	arg1	ingredients					143:153	plant-based high-protein ingredients	118:153	plant-based high-protein ingredients	118:153	Comparative study of sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients.
33709392	8	14	theme	glucose	1811:1817	arg1	levels					1783:1788	their levels	1777:1788	their levels of sucrose, maltose, glucose and fructose	1777:1830	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	15	theme	fructose	1823:1830	arg1	levels					1783:1788	their levels	1777:1788	their levels of sucrose, maltose, glucose and fructose	1777:1830	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	7	16	theme	Carrez	1449:1454	arg1	clarification					1456:1468	Carrez clarification	1449:1468	Carrez clarification	1449:1468	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	4	17	theme	sugar	848:852	arg1	levels					854:859	the sugar levels	844:859	the sugar levels in wheat flour and wholemeal wheat flour determined with different aqueous and ethanolic extraction procedures	844:970	The present study compares the sugar levels in wheat flour and wholemeal wheat flour determined with different aqueous and ethanolic extraction procedures.
33709392	8	18	theme	faba	1755:1758	arg1	soy					1713:1715	soy	1713:1715	soy	1713:1715	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	18	theme	faba	1755:1758	arg1	bean					1760:1763	faba bean	1755:1763	faba bean	1755:1763	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	6	19	theme	employed	1298:1305	arg1	procedures					1318:1327	the employed extraction procedures	1294:1327	the employed extraction procedures	1294:1327	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	1	20	from	importance	182:191	arg1	sector					229:234	the food sector	220:234	the food sector	220:234	BACKGROUND The increasing importance of plant-based proteins in the food sector makes a reliable compositional analysis of plant-based high-protein ingredients a necessity.
33709392	6	21	from	Differences	1156:1166	arg1	levels					1177:1182	sugar levels	1171:1182	sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour)	1171:1270	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	4	22	theme	present	821:827	arg1	study					829:833	The present study	817:833	The present study	817:833	The present study compares the sugar levels in wheat flour and wholemeal wheat flour determined with different aqueous and ethanolic extraction procedures.
33709392	7	23	theme	Ethanolic	1330:1338	arg1	extraction					1340:1349	Ethanolic extraction	1330:1349	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification	1330:1468	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	8	24	theme	chosen	1867:1872	arg1	procedure					1885:1893	the chosen extraction procedure	1863:1893	the chosen extraction procedure	1863:1893	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	1	25	theme	increasing	171:180	arg1	importance					182:191	The increasing importance	167:191	The increasing importance of plant-based proteins in the food sector	167:234	BACKGROUND The increasing importance of plant-based proteins in the food sector makes a reliable compositional analysis of plant-based high-protein ingredients a necessity.
33709392	4	26	theme	wholemeal	880:888	arg1	flour					896:900	wholemeal wheat flour	880:900	wholemeal wheat flour	880:900	The present study compares the sugar levels in wheat flour and wholemeal wheat flour determined with different aqueous and ethanolic extraction procedures.
33709392	1	27	dep	BACKGROUND	156:165	arg1	makes					236:240	makes	236:240	makes a reliable compositional analysis of plant-based high-protein ingredients a necessity	236:326	BACKGROUND The increasing importance of plant-based proteins in the food sector makes a reliable compositional analysis of plant-based high-protein ingredients a necessity.
33709392	8	28	theme	procedure	1885:1893	arg1	applicability					1846:1858	the applicability	1842:1858	the applicability of the chosen extraction procedure	1842:1893	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	6	29	dep	RESULTS	1148:1154	arg1	observed					1277:1284	observed	1277:1284	were observed between the employed extraction procedures	1272:1327	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	2	30	theme	product	438:444	arg1	development					446:456	food product development	433:456	food product development	433:456	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	0	31	theme	extraction	96:105	arg1	method					107:112	an ethanolic extraction method	83:112	an ethanolic extraction method for plant-based high-protein ingredients	83:153	Comparative study of sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients.
33709392	6	32	theme	glucose	1209:1215	arg1	sum					1185:1187	sum	1185:1187	sum of sucrose/maltose, glucose and fructose	1185:1228	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	0	33	theme	Comparative	0:10	arg1	study					12:16	Comparative study	0:16	Comparative study of sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients.	0:154	Comparative study of sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients.
33709392	1	34	theme	ingredients	304:314	arg1	analysis					267:274	a reliable compositional analysis	242:274	a reliable compositional analysis of plant-based high-protein ingredients a necessity	242:326	BACKGROUND The increasing importance of plant-based proteins in the food sector makes a reliable compositional analysis of plant-based high-protein ingredients a necessity.
33709392	8	35	theme	ingredients	1607:1617	arg1	screening					1581:1589	A screening	1579:1589	A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose	1579:1830	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	7	36	theme	agent	1418:1422	arg1	use					1393:1395	the use	1389:1395	the use of the antimicrobial agent sodium azide	1389:1435	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	2	37	theme	fundamental	478:488	arg1	chemistry					495:503	fundamental food chemistry	478:503	fundamental food chemistry	478:503	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	7	38	with	extraction	1340:1349	arg1	use					1393:1395	the use	1389:1395	the use of the antimicrobial agent sodium azide	1389:1435	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	5	39	theme	relevant	1089:1096	arg1	challenges					1098:1107	the most relevant challenges	1080:1107	the most relevant challenges in sugar extraction from food samples	1080:1145	These procedures included measures to prevent enzyme activity and microbial growth, which represent two of the most relevant challenges in sugar extraction from food samples.
33709392	7	40	dep	extraction	1340:1349	arg1	ethanol					1356:1362	80% ethanol	1352:1362	80% ethanol in ultrapure water	1352:1381	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	4	41	theme	ethanolic	940:948	arg1	procedures					961:970	different aqueous and ethanolic extraction procedures	918:970	different aqueous and ethanolic extraction procedures	918:970	The present study compares the sugar levels in wheat flour and wholemeal wheat flour determined with different aqueous and ethanolic extraction procedures.
33709392	0	42	theme	extraction	27:36	arg1	procedures					38:47	sugar extraction procedures	21:47	sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients	21:153	Comparative study of sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients.
33709392	7	43	dep	agent	1418:1422	arg1	azide					1431:1435	sodium azide	1424:1435	the antimicrobial agent sodium azide	1400:1435	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	2	44	theme	food	509:512	arg1	research					525:532	food technology research	509:532	food technology research	509:532	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	3	45	theme	used	544:547	arg1	procedures					560:569	Commonly used extraction procedures	535:569	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates	535:683	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates have been discussed controversially regarding a range of complications that can potentially lead to inaccurate sugar determination.
33709392	8	46	dep	CONCLUSION	1568:1577	arg1	confirmed					1832:1840	confirmed	1832:1840	confirmed the applicability of the chosen extraction procedure	1832:1893	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	6	47	theme	%	1245:1245	arg1	matter					1251:1256	1.8% dry matter	1242:1256	1.8% dry matter (wheat flour)	1242:1270	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	6	47	theme	%	1245:1245	arg1	flour					1265:1269	wheat flour	1259:1269	wheat flour	1259:1269	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	3	48	theme	sugar	796:800	arg1	determination					802:814	inaccurate sugar determination	785:814	inaccurate sugar determination	785:814	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates have been discussed controversially regarding a range of complications that can potentially lead to inaccurate sugar determination.
33709392	2	49	theme	short-chain	365:375	arg1	carbohydrates					377:389	short-chain carbohydrates	365:389	short-chain carbohydrates	365:389	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	8	50	dep	pseudocereals	1656:1668	arg1	buckwheat					1689:1697	buckwheat	1689:1697	buckwheat	1689:1697	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	50	dep	pseudocereals	1656:1668	arg1	amaranth					1679:1686	amaranth	1679:1686	amaranth	1679:1686	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	50	dep	pseudocereals	1656:1668	arg1	quinoa					1671:1676	quinoa	1671:1676	quinoa	1671:1676	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	5	51	theme	food	1134:1137	arg1	samples					1139:1145	food samples	1134:1145	food samples	1134:1145	These procedures included measures to prevent enzyme activity and microbial growth, which represent two of the most relevant challenges in sugar extraction from food samples.
33709392	4	52	theme	aqueous	928:934	arg1	procedures					961:970	different aqueous and ethanolic extraction procedures	918:970	different aqueous and ethanolic extraction procedures	918:970	The present study compares the sugar levels in wheat flour and wholemeal wheat flour determined with different aqueous and ethanolic extraction procedures.
33709392	3	53	theme	subsequent	575:584	arg1	separation					626:635	subsequent high-performance liquid chromatographic separation	575:635	subsequent high-performance liquid chromatographic separation	575:635	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates have been discussed controversially regarding a range of complications that can potentially lead to inaccurate sugar determination.
33709392	1	54	theme	reliable	244:251	arg1	analysis					267:274	a reliable compositional analysis	242:274	a reliable compositional analysis of plant-based high-protein ingredients a necessity	242:326	BACKGROUND The increasing importance of plant-based proteins in the food sector makes a reliable compositional analysis of plant-based high-protein ingredients a necessity.
33709392	7	55	theme	%	1354:1354	arg1	ethanol					1356:1362	80% ethanol	1352:1362	80% ethanol in ultrapure water	1352:1381	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	8	56	attach	derived	1619:1625	arg1	legumes					1704:1710	legumes	1704:1710	legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean)	1704:1764	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	56	attach	derived	1619:1625	arg2	ingredients					1607:1617	high-protein ingredients	1594:1617	high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose	1594:1830	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	56	attach	derived	1619:1625	arg1	cereals					1632:1638	cereals	1632:1638	cereals (wheat gluten)	1632:1653	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	56	attach	derived	1619:1625	arg1	gluten					1647:1652	wheat gluten	1641:1652	wheat gluten	1641:1652	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	56	attach	derived	1619:1625	arg1	pseudocereals					1656:1668	pseudocereals	1656:1668	pseudocereals (quinoa, amaranth, buckwheat)	1656:1698	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	1	57	theme	plant-based	279:289	arg1	ingredients					304:314	plant-based high-protein ingredients	279:314	plant-based high-protein ingredients a necessity	279:326	BACKGROUND The increasing importance of plant-based proteins in the food sector makes a reliable compositional analysis of plant-based high-protein ingredients a necessity.
33709392	7	58	from	ethanol	1356:1362	arg1	water					1377:1381	ultrapure water	1367:1381	ultrapure water	1367:1381	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	3	59	theme	liquid	603:608	arg1	separation					626:635	subsequent high-performance liquid chromatographic separation	575:635	subsequent high-performance liquid chromatographic separation	575:635	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates have been discussed controversially regarding a range of complications that can potentially lead to inaccurate sugar determination.
33709392	7	60	theme	plant-based	1530:1540	arg1	ingredients					1555:1565	plant-based high-protein ingredients	1530:1565	plant-based high-protein ingredients	1530:1565	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	3	61	theme	short-chain	659:669	arg1	carbohydrates					671:683	short-chain carbohydrates	659:683	short-chain carbohydrates	659:683	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates have been discussed controversially regarding a range of complications that can potentially lead to inaccurate sugar determination.
33709392	1	62	theme	plant-based	196:206	arg1	proteins					208:215	plant-based proteins	196:215	plant-based proteins	196:215	BACKGROUND The increasing importance of plant-based proteins in the food sector makes a reliable compositional analysis of plant-based high-protein ingredients a necessity.
33709392	6	63	theme	wheat	1259:1263	arg1	matter					1251:1256	1.8% dry matter	1242:1256	1.8% dry matter (wheat flour)	1242:1270	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	6	63	theme	wheat	1259:1263	arg1	flour					1265:1269	wheat flour	1259:1269	wheat flour	1259:1269	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	0	64	theme	plant-based	118:128	arg1	ingredients					143:153	plant-based high-protein ingredients	118:153	plant-based high-protein ingredients	118:153	Comparative study of sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients.
33709392	2	65	theme	carbohydrates	377:389	arg1	relevant					394:401	relevant	394:401	relevant	394:401	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	2	65	theme	carbohydrates	377:389	arg1	quantification					347:360	the quantification	343:360	the quantification of short-chain carbohydrates	343:389	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	5	66	theme	enzyme	1019:1024	arg1	activity					1026:1033	enzyme activity	1019:1033	enzyme activity	1019:1033	These procedures included measures to prevent enzyme activity and microbial growth, which represent two of the most relevant challenges in sugar extraction from food samples.
33709392	1	67	theme	food	224:227	arg1	sector					229:234	the food sector	220:234	the food sector	220:234	BACKGROUND The increasing importance of plant-based proteins in the food sector makes a reliable compositional analysis of plant-based high-protein ingredients a necessity.
33709392	8	68	theme	high-protein	1594:1605	arg1	ingredients					1607:1617	high-protein ingredients	1594:1617	high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose	1594:1830	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	6	69	theme	sugar	1171:1175	arg1	levels					1177:1182	sugar levels	1171:1182	sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour)	1171:1270	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	6	70	theme	extraction	1307:1316	arg1	procedures					1318:1327	the employed extraction procedures	1294:1327	the employed extraction procedures	1294:1327	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	7	71	theme	ultrapure	1367:1375	arg1	water					1377:1381	ultrapure water	1367:1381	ultrapure water	1367:1381	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	7	72	from	determination	1513:1525	arg1	ingredients					1555:1565	plant-based high-protein ingredients	1530:1565	plant-based high-protein ingredients	1530:1565	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	5	73	theme	microbial	1039:1047	arg1	growth					1049:1054	microbial growth	1039:1054	microbial growth	1039:1054	These procedures included measures to prevent enzyme activity and microbial growth, which represent two of the most relevant challenges in sugar extraction from food samples.
33709392	8	74	theme	wheat	1641:1645	arg1	cereals					1632:1638	cereals	1632:1638	cereals (wheat gluten)	1632:1653	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	74	theme	wheat	1641:1645	arg1	gluten					1647:1652	wheat gluten	1641:1652	wheat gluten	1641:1652	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	0	75	theme	ethanolic	86:94	arg1	method					107:112	an ethanolic extraction method	83:112	an ethanolic extraction method for plant-based high-protein ingredients	83:153	Comparative study of sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients.
33709392	5	76	theme	challenges	1098:1107	arg1	challenges					1098:1107	the most relevant challenges	1080:1107	the most relevant challenges in sugar extraction from food samples	1080:1145	These procedures included measures to prevent enzyme activity and microbial growth, which represent two of the most relevant challenges in sugar extraction from food samples.
33709392	5	76	theme	challenges	1098:1107	arg1	two					1073:1075	two	1073:1075	two	1073:1075	These procedures included measures to prevent enzyme activity and microbial growth, which represent two of the most relevant challenges in sugar extraction from food samples.
33709392	6	77	dep	levels	1177:1182	arg1	sum					1185:1187	sum	1185:1187	sum of sucrose/maltose, glucose and fructose	1185:1228	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	0	78	theme	method	107:112	arg1	proposal					71:78	proposal	71:78	proposal	71:78	Comparative study of sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients.
33709392	0	78	theme	method	107:112	arg1	analysis					58:65	HPLC analysis	53:65	HPLC analysis	53:65	Comparative study of sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients.
33709392	8	79	theme	extraction	1874:1883	arg1	procedure					1885:1893	the chosen extraction procedure	1863:1893	the chosen extraction procedure	1863:1893	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	5	80	theme	sugar	1112:1116	arg1	extraction					1118:1127	sugar extraction	1112:1127	sugar extraction from food samples	1112:1145	These procedures included measures to prevent enzyme activity and microbial growth, which represent two of the most relevant challenges in sugar extraction from food samples.
33709392	7	81	theme	sodium	1424:1429	arg1	azide					1431:1435	sodium azide	1424:1435	the antimicrobial agent sodium azide	1400:1435	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	4	82	theme	wheat	890:894	arg1	flour					896:900	wholemeal wheat flour	880:900	wholemeal wheat flour	880:900	The present study compares the sugar levels in wheat flour and wholemeal wheat flour determined with different aqueous and ethanolic extraction procedures.
33709392	2	83	theme	food	433:436	arg1	development					446:456	food product development	433:456	food product development	433:456	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	8	84	dep	legumes	1704:1710	arg1	soy					1713:1715	soy	1713:1715	soy	1713:1715	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	84	dep	legumes	1704:1710	arg1	lentil					1730:1735	lentil	1730:1735	lentil	1730:1735	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	84	dep	legumes	1704:1710	arg1	carob					1738:1742	carob	1738:1742	carob	1738:1742	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	84	dep	legumes	1704:1710	arg1	pea					1718:1720	pea	1718:1720	pea	1718:1720	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	84	dep	legumes	1704:1710	arg1	lupin					1723:1727	lupin	1723:1727	lupin	1723:1727	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	84	dep	legumes	1704:1710	arg1	chickpea					1745:1752	chickpea	1745:1752	chickpea	1745:1752	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	8	84	dep	legumes	1704:1710	arg1	bean					1760:1763	faba bean	1755:1763	faba bean	1755:1763	CONCLUSION A screening of high-protein ingredients derived from cereals (wheat gluten), pseudocereals (quinoa, amaranth, buckwheat) and legumes (soy, pea, lupin, lentil, carob, chickpea, faba bean) concerning their levels of sucrose, maltose, glucose and fructose confirmed the applicability of the chosen extraction procedure.
33709392	7	85	theme	antimicrobial	1404:1416	arg1	agent					1418:1422	the antimicrobial agent sodium azide	1400:1435	the antimicrobial agent sodium azide	1400:1435	Ethanolic extraction (80% ethanol in ultrapure water) with the use of the antimicrobial agent sodium azide but without Carrez clarification was identified as most promising for sugar determination in plant-based high-protein ingredients.
33709392	2	86	theme	food	490:493	arg1	chemistry					495:503	fundamental food chemistry	478:503	fundamental food chemistry	478:503	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	0	87	theme	sugar	21:25	arg1	procedures					38:47	sugar extraction procedures	21:47	sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients	21:153	Comparative study of sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients.
33709392	4	88	from	levels	854:859	arg1	flour					870:874	wheat flour	864:874	wheat flour	864:874	The present study compares the sugar levels in wheat flour and wholemeal wheat flour determined with different aqueous and ethanolic extraction procedures.
33709392	4	88	from	levels	854:859	arg1	flour					896:900	wholemeal wheat flour	880:900	wholemeal wheat flour	880:900	The present study compares the sugar levels in wheat flour and wholemeal wheat flour determined with different aqueous and ethanolic extraction procedures.
33709392	4	89	theme	wheat	864:868	arg1	flour					870:874	wheat flour	864:874	wheat flour	864:874	The present study compares the sugar levels in wheat flour and wholemeal wheat flour determined with different aqueous and ethanolic extraction procedures.
33709392	2	90	theme	food	459:462	arg1	labelling					464:472	food labelling	459:472	food labelling	459:472	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	0	91	theme	procedures	38:47	arg1	study					12:16	Comparative study	0:16	Comparative study of sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients.	0:154	Comparative study of sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients.
33709392	2	92	theme	technology	514:523	arg1	research					525:532	food technology research	509:532	food technology research	509:532	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	3	93	theme	complications	742:754	arg1	range					733:737	a range	731:737	a range of complications that can potentially lead to inaccurate sugar determination	731:814	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates have been discussed controversially regarding a range of complications that can potentially lead to inaccurate sugar determination.
33709392	0	94	theme	HPLC	53:56	arg1	analysis					58:65	HPLC analysis	53:65	HPLC analysis	53:65	Comparative study of sugar extraction procedures for HPLC analysis and proposal of an ethanolic extraction method for plant-based high-protein ingredients.
33709392	6	95	theme	dry	1247:1249	arg1	matter					1251:1256	1.8% dry matter	1242:1256	1.8% dry matter (wheat flour)	1242:1270	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	6	95	theme	dry	1247:1249	arg1	flour					1265:1269	wheat flour	1259:1269	wheat flour	1259:1269	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	3	96	theme	inaccurate	785:794	arg1	determination					802:814	inaccurate sugar determination	785:814	inaccurate sugar determination	785:814	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates have been discussed controversially regarding a range of complications that can potentially lead to inaccurate sugar determination.
33709392	4	97	theme	extraction	950:959	arg1	procedures					961:970	different aqueous and ethanolic extraction procedures	918:970	different aqueous and ethanolic extraction procedures	918:970	The present study compares the sugar levels in wheat flour and wholemeal wheat flour determined with different aqueous and ethanolic extraction procedures.
33709392	3	98	theme	extraction	549:558	arg1	procedures					560:569	Commonly used extraction procedures	535:569	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates	535:683	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates have been discussed controversially regarding a range of complications that can potentially lead to inaccurate sugar determination.
33709392	6	99	theme	1.8	1242:1244	arg1	%					1245:1245	%	1245:1245	%	1245:1245	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	9	100	theme	Chemical	1914:1921	arg1	Industry					1923:1930	Chemical Industry	1914:1930	Chemical Industry	1914:1930	© 2021 Society of Chemical Industry.
33709392	2	101	theme	multiple	407:414	arg1	chemistry					495:503	fundamental food chemistry	478:503	fundamental food chemistry	478:503	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	2	101	theme	multiple	407:414	arg1	labelling					464:472	food labelling	459:472	food labelling	459:472	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	2	101	theme	multiple	407:414	arg1	research					525:532	food technology research	509:532	food technology research	509:532	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	2	101	theme	multiple	407:414	arg1	development					446:456	food product development	433:456	food product development	433:456	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	2	101	theme	multiple	407:414	arg1	areas					416:420	multiple areas	407:420	multiple areas	407:420	Specifically, the quantification of short-chain carbohydrates is relevant for multiple areas, including food product development, food labelling and fundamental food chemistry and food technology research.
33709392	6	102	theme	high	1234:1237	arg1	levels					1177:1182	sugar levels	1171:1182	sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour)	1171:1270	RESULTS Differences in sugar levels (sum of sucrose/maltose, glucose and fructose) as high as 1.8% dry matter (wheat flour) were observed between the employed extraction procedures.
33709392	4	103	theme	different	918:926	arg1	procedures					961:970	different aqueous and ethanolic extraction procedures	918:970	different aqueous and ethanolic extraction procedures	918:970	The present study compares the sugar levels in wheat flour and wholemeal wheat flour determined with different aqueous and ethanolic extraction procedures.
33709392	3	104	theme	high-performance	586:601	arg1	separation					626:635	subsequent high-performance liquid chromatographic separation	575:635	subsequent high-performance liquid chromatographic separation	575:635	Commonly used extraction procedures for subsequent high-performance liquid chromatographic separation and quantification of short-chain carbohydrates have been discussed controversially regarding a range of complications that can potentially lead to inaccurate sugar determination.
33709392	1	105	theme	compositional	253:265	arg1	analysis					267:274	a reliable compositional analysis	242:274	a reliable compositional analysis of plant-based high-protein ingredients a necessity	242:326	BACKGROUND The increasing importance of plant-based proteins in the food sector makes a reliable compositional analysis of plant-based high-protein ingredients a necessity.
33771541	2	0	theme	contaminated	454:465	arg1	water					467:471	contaminated water	454:471	contaminated water	454:471	In this work, gelatin hydrogels filled with cellulose in the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER) were prepared for adsorption and chromium removal in contaminated water.
33771541	1	1	theme	water	158:162	arg1	applications					174:185	water treatment applications	158:185	water treatment applications due to their abundance, low cost, expandability, and chemical structure	158:257	Biopolymers are promising materials for water treatment applications due to their abundance, low cost, expandability, and chemical structure.
33771541	1	2	theme	chemical	240:247	arg1	structure					249:257	chemical structure	240:257	chemical structure	240:257	Biopolymers are promising materials for water treatment applications due to their abundance, low cost, expandability, and chemical structure.
33771541	1	3	theme	treatment	164:172	arg1	applications					174:185	water treatment applications	158:185	water treatment applications due to their abundance, low cost, expandability, and chemical structure	158:257	Biopolymers are promising materials for water treatment applications due to their abundance, low cost, expandability, and chemical structure.
33771541	7	4	theme	adsorption	1152:1161	arg1	capacity					1163:1170	The chromium adsorption capacity	1139:1170	The chromium adsorption capacity	1139:1170	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	7	5	theme	surface	1323:1329	arg1	groups					1340:1345	surface hydroxyl groups	1323:1345	surface hydroxyl groups	1323:1345	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	7	6	dep	hydrogel	1281:1288	arg1	groups					1340:1345	surface hydroxyl groups	1323:1345	surface hydroxyl groups	1323:1345	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	7	6	dep	hydrogel	1281:1288	arg1	structure					1302:1310	crosslinked structure	1290:1310	crosslinked structure	1290:1310	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	2	7	theme	gelatin	274:280	arg1	hydrogels					282:290	gelatin hydrogels	274:290	gelatin hydrogels filled with cellulose in the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER)	274:399	In this work, gelatin hydrogels filled with cellulose in the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER) were prepared for adsorption and chromium removal in contaminated water.
33771541	0	8	dep	chromium	68:75	arg1	VI					78:79	VI	78:79	VI	78:79	Biodegradable gelatin composite hydrogels filled with cellulose for chromium (VI) adsorption from contaminated water.
33771541	0	8	dep	chromium	68:75	arg1	adsorption					82:91	adsorption	82:91	chromium (VI) adsorption from contaminated water	68:115	Biodegradable gelatin composite hydrogels filled with cellulose for chromium (VI) adsorption from contaminated water.
33771541	7	9	theme	chromium	1143:1150	arg1	capacity					1163:1170	The chromium adsorption capacity	1139:1170	The chromium adsorption capacity	1139:1170	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	4	10	theme	gelatin	730:736	arg1	vibrations					748:757	the gelatin molecular vibrations	726:757	the gelatin molecular vibrations	726:757	FT-Raman Spectroscopy and FTIR analysis confirmed the crosslink reaction with glutaraldehyde and indicated that fillers altered the gelatin molecular vibrations and formed new hydrogen bonds, impacting the hydrogels' crystalline structure.
33771541	2	11	theme	eucalyptus	338:347	arg1	residues					349:356	pristine eucalyptus residues	329:356	pristine eucalyptus residues (PER)	329:362	In this work, gelatin hydrogels filled with cellulose in the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER) were prepared for adsorption and chromium removal in contaminated water.
33771541	4	12	theme	crosslink	652:660	arg1	reaction					662:669	the crosslink reaction	648:669	the crosslink reaction	648:669	FT-Raman Spectroscopy and FTIR analysis confirmed the crosslink reaction with glutaraldehyde and indicated that fillers altered the gelatin molecular vibrations and formed new hydrogen bonds, impacting the hydrogels' crystalline structure.
33771541	8	13	theme	potential	1494:1502	arg1	application					1504:1514	low-cost and potential application	1481:1514	low-cost and potential application in contaminated water	1481:1536	The developed hydrogels were produced from biomacromolecules with low-cost and potential application in contaminated water.
33771541	4	14	theme	crystalline	815:825	arg1	structure					827:835	the hydrogels' crystalline structure	800:835	the hydrogels' crystalline structure	800:835	FT-Raman Spectroscopy and FTIR analysis confirmed the crosslink reaction with glutaraldehyde and indicated that fillers altered the gelatin molecular vibrations and formed new hydrogen bonds, impacting the hydrogels' crystalline structure.
33771541	6	15	theme	content	1121:1127	arg1	increase					1129:1136	the filler content increase	1110:1136	the filler content increase	1110:1136	Hydrogels presented a Fickian diffusion, where gelatin hydrogel showed the highest swelling ability (466%), and composites showed lower values with the filler content increase.
33771541	5	16	theme	bond	851:854	arg1	energy					856:861	The hydrogen bond energy	838:861	The hydrogen bond energy	838:861	The hydrogen bond energy was altered by the cellulosic fillers' addition and resulted in higher thermal stability (~10 °C).
33771541	2	17	theme	treated	367:373	arg1	residues					386:393	treated eucalyptus residues	367:393	treated eucalyptus residues (TER)	367:399	In this work, gelatin hydrogels filled with cellulose in the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER) were prepared for adsorption and chromium removal in contaminated water.
33771541	2	17	theme	treated	367:373	arg1	TER					396:398	TER	396:398	TER	396:398	In this work, gelatin hydrogels filled with cellulose in the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER) were prepared for adsorption and chromium removal in contaminated water.
33771541	0	18	theme	contaminated	98:109	arg1	water					111:115	contaminated water	98:115	contaminated water	98:115	Biodegradable gelatin composite hydrogels filled with cellulose for chromium (VI) adsorption from contaminated water.
33771541	8	19	theme	contaminated	1519:1530	arg1	water					1532:1536	contaminated water	1519:1536	contaminated water	1519:1536	The developed hydrogels were produced from biomacromolecules with low-cost and potential application in contaminated water.
33771541	7	20	with	%	1383:1383	arg1	capacity					1405:1412	better removal capacity	1390:1412	better removal capacity	1390:1412	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	2	21	dep	residues	349:356	arg1	PER					359:361	PER	359:361	PER	359:361	In this work, gelatin hydrogels filled with cellulose in the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER) were prepared for adsorption and chromium removal in contaminated water.
33771541	1	22	theme	due	187:189	arg1	applications					174:185	water treatment applications	158:185	water treatment applications due to their abundance, low cost, expandability, and chemical structure	158:257	Biopolymers are promising materials for water treatment applications due to their abundance, low cost, expandability, and chemical structure.
33771541	0	23	theme	gelatin	14:20	arg1	composite					22:30	Biodegradable gelatin composite	0:30	Biodegradable gelatin composite	0:30	Biodegradable gelatin composite hydrogels filled with cellulose for chromium (VI) adsorption from contaminated water.
33771541	3	24	theme	lignocellulosic	483:497	arg1	compound					499:506	a lignocellulosic compound	481:506	a lignocellulosic compound	481:506	PER is a lignocellulosic compound, with cellulose, hemicellulose, and lignin, while TER has cellulose as a major component.
33771541	3	24	theme	lignocellulosic	483:497	arg1	PER					474:476	PER	474:476	PER	474:476	PER is a lignocellulosic compound, with cellulose, hemicellulose, and lignin, while TER has cellulose as a major component.
33771541	7	25	theme	removal	1242:1248	arg1	capacity					1250:1257	an excellent removal capacity	1229:1257	an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity	1229:1412	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	7	25	theme	removal	1242:1248	arg1	related					1268:1274	related	1268:1274	related	1268:1274	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	7	26	theme	TER	1378:1380	arg1	%					1383:1383	gelatin hydrogel TER 5%	1361:1383	gelatin hydrogel TER 5% with better removal capacity	1361:1412	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	6	27	theme	highest	1037:1043	arg1	ability					1054:1060	the highest swelling ability	1033:1060	the highest swelling ability	1033:1060	Hydrogels presented a Fickian diffusion, where gelatin hydrogel showed the highest swelling ability (466%), and composites showed lower values with the filler content increase.
33771541	4	28	theme	FT-Raman	598:605	arg1	Spectroscopy					607:618	FT-Raman Spectroscopy	598:618	FT-Raman Spectroscopy	598:618	FT-Raman Spectroscopy and FTIR analysis confirmed the crosslink reaction with glutaraldehyde and indicated that fillers altered the gelatin molecular vibrations and formed new hydrogen bonds, impacting the hydrogels' crystalline structure.
33771541	0	29	theme	Biodegradable	0:12	arg1	composite					22:30	Biodegradable gelatin composite	0:30	Biodegradable gelatin composite	0:30	Biodegradable gelatin composite hydrogels filled with cellulose for chromium (VI) adsorption from contaminated water.
33771541	7	30	theme	better	1390:1395	arg1	capacity					1405:1412	better removal capacity	1390:1412	better removal capacity	1390:1412	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	7	31	link	crosslinked	1290:1300	arg1	structure					1302:1310	crosslinked structure	1290:1310	crosslinked structure	1290:1310	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	4	32	theme	FTIR	624:627	arg1	analysis					629:636	FTIR analysis	624:636	FTIR analysis	624:636	FT-Raman Spectroscopy and FTIR analysis confirmed the crosslink reaction with glutaraldehyde and indicated that fillers altered the gelatin molecular vibrations and formed new hydrogen bonds, impacting the hydrogels' crystalline structure.
33771541	6	33	theme	swelling	1045:1052	arg1	ability					1054:1060	the highest swelling ability	1033:1060	the highest swelling ability	1033:1060	Hydrogels presented a Fickian diffusion, where gelatin hydrogel showed the highest swelling ability (466%), and composites showed lower values with the filler content increase.
33771541	6	34	theme	gelatin	1009:1015	arg1	hydrogel					1017:1024	gelatin hydrogel	1009:1024	gelatin hydrogel	1009:1024	Hydrogels presented a Fickian diffusion, where gelatin hydrogel showed the highest swelling ability (466%), and composites showed lower values with the filler content increase.
33771541	5	35	theme	thermal	934:940	arg1	stability					942:950	higher thermal stability	927:950	higher thermal stability (~10 °C)	927:959	The hydrogen bond energy was altered by the cellulosic fillers' addition and resulted in higher thermal stability (~10 °C).
33771541	5	35	theme	thermal	934:940	arg1	~10 °C					953:958	~10 °C	953:958	~10 °C	953:958	The hydrogen bond energy was altered by the cellulosic fillers' addition and resulted in higher thermal stability (~10 °C).
33771541	6	36	dep	showed	1026:1031	arg1	%					1066:1066	466%	1063:1066	466%	1063:1066	Hydrogels presented a Fickian diffusion, where gelatin hydrogel showed the highest swelling ability (466%), and composites showed lower values with the filler content increase.
33771541	2	37	theme	pristine	329:336	arg1	residues					349:356	pristine eucalyptus residues	329:356	pristine eucalyptus residues (PER)	329:362	In this work, gelatin hydrogels filled with cellulose in the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER) were prepared for adsorption and chromium removal in contaminated water.
33771541	3	38	with	compound	499:506	arg1	hemicellulose					525:537	hemicellulose	525:537	hemicellulose	525:537	PER is a lignocellulosic compound, with cellulose, hemicellulose, and lignin, while TER has cellulose as a major component.
33771541	3	38	with	compound	499:506	arg1	lignin					544:549	lignin	544:549	lignin	544:549	PER is a lignocellulosic compound, with cellulose, hemicellulose, and lignin, while TER has cellulose as a major component.
33771541	3	38	with	compound	499:506	arg1	cellulose					514:522	cellulose	514:522	cellulose	514:522	PER is a lignocellulosic compound, with cellulose, hemicellulose, and lignin, while TER has cellulose as a major component.
33771541	1	39	theme	low	211:213	arg1	cost					215:218	low cost	211:218	low cost	211:218	Biopolymers are promising materials for water treatment applications due to their abundance, low cost, expandability, and chemical structure.
33771541	8	40	with	biomacromolecules	1458:1474	arg1	application					1504:1514	low-cost and potential application	1481:1514	low-cost and potential application in contaminated water	1481:1536	The developed hydrogels were produced from biomacromolecules with low-cost and potential application in contaminated water.
33771541	2	41	theme	residues	386:393	arg1	form					321:324	the form	317:324	the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER)	317:399	In this work, gelatin hydrogels filled with cellulose in the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER) were prepared for adsorption and chromium removal in contaminated water.
33771541	2	42	theme	chromium	434:441	arg1	removal					443:449	chromium removal	434:449	chromium removal	434:449	In this work, gelatin hydrogels filled with cellulose in the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER) were prepared for adsorption and chromium removal in contaminated water.
33771541	3	43	theme	major	581:585	arg1	cellulose					566:574	cellulose	566:574	cellulose	566:574	PER is a lignocellulosic compound, with cellulose, hemicellulose, and lignin, while TER has cellulose as a major component.
33771541	3	43	theme	major	581:585	arg1	component					587:595	a major component	579:595	a major component	579:595	PER is a lignocellulosic compound, with cellulose, hemicellulose, and lignin, while TER has cellulose as a major component.
33771541	2	44	theme	eucalyptus	375:384	arg1	residues					386:393	treated eucalyptus residues	367:393	treated eucalyptus residues (TER)	367:399	In this work, gelatin hydrogels filled with cellulose in the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER) were prepared for adsorption and chromium removal in contaminated water.
33771541	2	44	theme	eucalyptus	375:384	arg1	TER					396:398	TER	396:398	TER	396:398	In this work, gelatin hydrogels filled with cellulose in the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER) were prepared for adsorption and chromium removal in contaminated water.
33771541	8	45	from	application	1504:1514	arg1	water					1532:1536	contaminated water	1519:1536	contaminated water	1519:1536	The developed hydrogels were produced from biomacromolecules with low-cost and potential application in contaminated water.
33771541	7	46	with	related	1268:1274	arg1	fibers					1316:1321	fibers	1316:1321	fibers	1316:1321	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	7	46	with	related	1268:1274	arg1	hydrogel					1281:1288	hydrogel crosslinked structure and fibers surface hydroxyl groups	1281:1345	hydrogel	1281:1288	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	7	47	theme	hydroxyl	1331:1338	arg1	groups					1340:1345	surface hydroxyl groups	1323:1345	surface hydroxyl groups	1323:1345	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	5	48	theme	cellulosic	882:891	arg1	fillers					893:899	the cellulosic fillers'	878:900	the cellulosic fillers' addition	878:909	The hydrogen bond energy was altered by the cellulosic fillers' addition and resulted in higher thermal stability (~10 °C).
33771541	8	49	theme	low-cost	1481:1488	arg1	application					1504:1514	low-cost and potential application	1481:1514	low-cost and potential application in contaminated water	1481:1536	The developed hydrogels were produced from biomacromolecules with low-cost and potential application in contaminated water.
33771541	0	50	from	water	111:115	arg1	chromium					68:75	chromium (VI) adsorption from contaminated water	68:115	chromium (VI) adsorption from contaminated water	68:115	Biodegradable gelatin composite hydrogels filled with cellulose for chromium (VI) adsorption from contaminated water.
33771541	7	51	theme	crosslinked	1290:1300	arg1	structure					1302:1310	crosslinked structure	1290:1310	crosslinked structure	1290:1310	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	7	52	theme	excellent	1232:1240	arg1	capacity					1250:1257	an excellent removal capacity	1229:1257	an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity	1229:1412	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	7	52	theme	excellent	1232:1240	arg1	related					1268:1274	related	1268:1274	related	1268:1274	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	4	53	theme	new	770:772	arg1	bonds					783:787	new hydrogen bonds	770:787	new hydrogen bonds	770:787	FT-Raman Spectroscopy and FTIR analysis confirmed the crosslink reaction with glutaraldehyde and indicated that fillers altered the gelatin molecular vibrations and formed new hydrogen bonds, impacting the hydrogels' crystalline structure.
33771541	0	54	dep	hydrogels	32:40	arg1	filled					42:47	filled	42:47	hydrogels filled with cellulose for chromium (VI) adsorption from contaminated water	32:115	Biodegradable gelatin composite hydrogels filled with cellulose for chromium (VI) adsorption from contaminated water.
33771541	7	55	theme	gelatin	1361:1367	arg1	%					1383:1383	gelatin hydrogel TER 5%	1361:1383	gelatin hydrogel TER 5% with better removal capacity	1361:1412	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	7	56	theme	hydrogel	1369:1376	arg1	%					1383:1383	gelatin hydrogel TER 5%	1361:1383	gelatin hydrogel TER 5% with better removal capacity	1361:1412	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	6	57	theme	filler	1114:1119	arg1	content					1121:1127	the filler content	1110:1127	the filler content increase	1110:1136	Hydrogels presented a Fickian diffusion, where gelatin hydrogel showed the highest swelling ability (466%), and composites showed lower values with the filler content increase.
33771541	4	58	theme	molecular	738:746	arg1	vibrations					748:757	the gelatin molecular vibrations	726:757	the gelatin molecular vibrations	726:757	FT-Raman Spectroscopy and FTIR analysis confirmed the crosslink reaction with glutaraldehyde and indicated that fillers altered the gelatin molecular vibrations and formed new hydrogen bonds, impacting the hydrogels' crystalline structure.
33771541	1	59	theme	promising	134:142	arg1	Biopolymers					118:128	Biopolymers	118:128	Biopolymers	118:128	Biopolymers are promising materials for water treatment applications due to their abundance, low cost, expandability, and chemical structure.
33771541	1	59	theme	promising	134:142	arg1	materials					144:152	promising materials	134:152	promising materials for water treatment applications due to their abundance, low cost, expandability, and chemical structure	134:257	Biopolymers are promising materials for water treatment applications due to their abundance, low cost, expandability, and chemical structure.
33771541	3	60	contain	has	562:564	arg2	cellulose					566:574	cellulose	566:574	cellulose	566:574	PER is a lignocellulosic compound, with cellulose, hemicellulose, and lignin, while TER has cellulose as a major component.
33771541	3	60	contain	has	562:564	arg1	TER					558:560	TER	558:560	TER	558:560	PER is a lignocellulosic compound, with cellulose, hemicellulose, and lignin, while TER has cellulose as a major component.
33771541	3	60	contain	has	562:564	arg2	component					587:595	a major component	579:595	a major component	579:595	PER is a lignocellulosic compound, with cellulose, hemicellulose, and lignin, while TER has cellulose as a major component.
33771541	8	61	theme	developed	1419:1427	arg1	hydrogels					1429:1437	The developed hydrogels	1415:1437	The developed hydrogels	1415:1437	The developed hydrogels were produced from biomacromolecules with low-cost and potential application in contaminated water.
33771541	7	62	theme	removal	1397:1403	arg1	capacity					1405:1412	better removal capacity	1390:1412	better removal capacity	1390:1412	The chromium adsorption capacity presented values between 12 and 13 mg/g, i.e., featuring an excellent removal capacity which is related with hydrogel crosslinked structure and fibers surface hydroxyl groups, highlighting gelatin hydrogel TER 5% with better removal capacity.
33771541	5	63	theme	higher	927:932	arg1	stability					942:950	higher thermal stability	927:950	higher thermal stability (~10 °C)	927:959	The hydrogen bond energy was altered by the cellulosic fillers' addition and resulted in higher thermal stability (~10 °C).
33771541	5	63	theme	higher	927:932	arg1	~10 °C					953:958	~10 °C	953:958	~10 °C	953:958	The hydrogen bond energy was altered by the cellulosic fillers' addition and resulted in higher thermal stability (~10 °C).
33771541	5	64	theme	hydrogen	842:849	arg1	bond					851:854	The hydrogen bond	838:854	The hydrogen bond energy	838:861	The hydrogen bond energy was altered by the cellulosic fillers' addition and resulted in higher thermal stability (~10 °C).
33771541	6	65	theme	Fickian	984:990	arg1	diffusion					992:1000	a Fickian diffusion	982:1000	a Fickian diffusion	982:1000	Hydrogels presented a Fickian diffusion, where gelatin hydrogel showed the highest swelling ability (466%), and composites showed lower values with the filler content increase.
33771541	6	66	theme	lower	1092:1096	arg1	values					1098:1103	lower values	1092:1103	lower values	1092:1103	Hydrogels presented a Fickian diffusion, where gelatin hydrogel showed the highest swelling ability (466%), and composites showed lower values with the filler content increase.
33771541	4	67	theme	hydrogen	774:781	arg1	bonds					783:787	new hydrogen bonds	770:787	new hydrogen bonds	770:787	FT-Raman Spectroscopy and FTIR analysis confirmed the crosslink reaction with glutaraldehyde and indicated that fillers altered the gelatin molecular vibrations and formed new hydrogen bonds, impacting the hydrogels' crystalline structure.
33771541	2	68	theme	residues	349:356	arg1	form					321:324	the form	317:324	the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER)	317:399	In this work, gelatin hydrogels filled with cellulose in the form of pristine eucalyptus residues (PER) or treated eucalyptus residues (TER) were prepared for adsorption and chromium removal in contaminated water.
32813896	0	0	theme	gut	87:89	arg1	reconstitution					65:78	post-antibiotic reconstitution	49:78	post-antibiotic reconstitution of the gut	49:89	Effects of the prebiotic inulin-type fructans on post-antibiotic reconstitution of the gut microbiome.
32813896	8	1	theme	genes	1576:1580	arg1	restoration					1542:1552	the restoration	1538:1552	the restoration of the immunoglobulin genes	1538:1580	Both ITFs supplementation and spontaneous recovery could restore the colonic transcriptome nearly to the initial profile to a certain extent; however, ITFs supplementation delayed the restoration of the immunoglobulin genes compared to spontaneous recovery.
32813896	7	2	theme	bacteria	1177:1184	arg1	abundance					1148:1156	the relative abundance	1135:1156	the relative abundance of some beneficial bacteria and butyrate levels	1135:1204	ITFs supplementation increased the relative abundance of some beneficial bacteria and butyrate levels, but resulted in selective blooms of some opportunistic pathogens and elevated the pathways associated with diseases linked to gut microbiota function.
32813896	4	3	theme	RESULTS	607:613	arg1	mice					627:630	METHODS AND RESULTS Male BALB/c mice	595:630	METHODS AND RESULTS Male BALB/c mice	595:630	METHODS AND RESULTS Male BALB/c mice were subjected to an antibiotic cocktail (ABx) treatment for 7 days, and their microbiomes were then reconstituted either spontaneously or with ITFs supplementation (5%) for 14 days.
32813896	7	4	theme	beneficial	1166:1175	arg1	bacteria					1177:1184	some beneficial bacteria	1161:1184	some beneficial bacteria	1161:1184	ITFs supplementation increased the relative abundance of some beneficial bacteria and butyrate levels, but resulted in selective blooms of some opportunistic pathogens and elevated the pathways associated with diseases linked to gut microbiota function.
32813896	9	5	theme	potential	1743:1751	arg1	effects					1761:1767	potential adverse effects	1743:1767	potential adverse effects in the context of dysbiosis	1743:1795	CONCLUSION These data showed that post-antibiotic ITFs consumption did not always lead to beneficial effects but might lead to potential adverse effects in the context of dysbiosis.
32813896	3	6	theme	intestinal	515:524	arg1	microbiota					526:535	the intestinal microbiota	511:535	the intestinal microbiota	511:535	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	7	7	theme	opportunistic	1248:1260	arg1	pathogens					1262:1270	some opportunistic pathogens	1243:1270	some opportunistic pathogens	1243:1270	ITFs supplementation increased the relative abundance of some beneficial bacteria and butyrate levels, but resulted in selective blooms of some opportunistic pathogens and elevated the pathways associated with diseases linked to gut microbiota function.
32813896	0	8	from	Effects	0:6	arg1	reconstitution					65:78	post-antibiotic reconstitution	49:78	post-antibiotic reconstitution of the gut	49:89	Effects of the prebiotic inulin-type fructans on post-antibiotic reconstitution of the gut microbiome.
32813896	9	9	theme	adverse	1753:1759	arg1	effects					1761:1767	potential adverse effects	1743:1767	potential adverse effects in the context of dysbiosis	1743:1795	CONCLUSION These data showed that post-antibiotic ITFs consumption did not always lead to beneficial effects but might lead to potential adverse effects in the context of dysbiosis.
32813896	2	10	theme	ITFs	287:290	arg1	impacts					276:282	the impacts	272:282	the impacts of ITFs on post-antibiotic reconstitution of the gut microbiome	272:346	However, the impacts of ITFs on post-antibiotic reconstitution of the gut microbiome remain incompletely understood.
32813896	4	11	theme	BALB/c	620:625	arg1	mice					627:630	METHODS AND RESULTS Male BALB/c mice	595:630	METHODS AND RESULTS Male BALB/c mice	595:630	METHODS AND RESULTS Male BALB/c mice were subjected to an antibiotic cocktail (ABx) treatment for 7 days, and their microbiomes were then reconstituted either spontaneously or with ITFs supplementation (5%) for 14 days.
32813896	7	12	theme	pathogens	1262:1270	arg1	blooms					1233:1238	selective blooms	1223:1238	selective blooms of some opportunistic pathogens	1223:1270	ITFs supplementation increased the relative abundance of some beneficial bacteria and butyrate levels, but resulted in selective blooms of some opportunistic pathogens and elevated the pathways associated with diseases linked to gut microbiota function.
32813896	3	13	theme	antibiotic	573:582	arg1	treatment					584:592	antibiotic treatment	573:592	antibiotic treatment	573:592	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	4	14	theme	ITFs	776:779	arg1	supplementation					781:795	ITFs supplementation	776:795	ITFs supplementation (5%) for 14 days	776:812	METHODS AND RESULTS Male BALB/c mice were subjected to an antibiotic cocktail (ABx) treatment for 7 days, and their microbiomes were then reconstituted either spontaneously or with ITFs supplementation (5%) for 14 days.
32813896	4	14	theme	ITFs	776:779	arg1	%					799:799	5%	798:799	5%	798:799	METHODS AND RESULTS Male BALB/c mice were subjected to an antibiotic cocktail (ABx) treatment for 7 days, and their microbiomes were then reconstituted either spontaneously or with ITFs supplementation (5%) for 14 days.
32813896	4	15	theme	Male	615:618	arg1	mice					627:630	METHODS AND RESULTS Male BALB/c mice	595:630	METHODS AND RESULTS Male BALB/c mice	595:630	METHODS AND RESULTS Male BALB/c mice were subjected to an antibiotic cocktail (ABx) treatment for 7 days, and their microbiomes were then reconstituted either spontaneously or with ITFs supplementation (5%) for 14 days.
32813896	7	16	theme	microbiota	1337:1346	arg1	function					1348:1355	gut microbiota function	1333:1355	gut microbiota function	1333:1355	ITFs supplementation increased the relative abundance of some beneficial bacteria and butyrate levels, but resulted in selective blooms of some opportunistic pathogens and elevated the pathways associated with diseases linked to gut microbiota function.
32813896	5	17	theme	ITFs	836:839	arg1	supplementation					841:855	ITFs supplementation	836:855	ITFs supplementation	836:855	Our data showed that ITFs supplementation delayed the recovery of antibiotic-induced colitis compared with the spontaneous recovery.
32813896	6	18	theme	initial	1083:1089	arg1	composition					1091:1101	its initial composition	1079:1101	its initial composition	1079:1101	Neither ITFs supplementation nor spontaneous recovery could restore the microbial community composition at the genus level back to its initial composition.
32813896	6	19	theme	microbial	1020:1028	arg1	composition					1040:1050	the microbial community composition	1016:1050	the microbial community composition	1016:1050	Neither ITFs supplementation nor spontaneous recovery could restore the microbial community composition at the genus level back to its initial composition.
32813896	7	20	theme	butyrate	1190:1197	arg1	levels					1199:1204	butyrate levels	1190:1204	butyrate levels	1190:1204	ITFs supplementation increased the relative abundance of some beneficial bacteria and butyrate levels, but resulted in selective blooms of some opportunistic pathogens and elevated the pathways associated with diseases linked to gut microbiota function.
32813896	3	21	theme	colonic	545:551	arg1	transcriptome					553:565	the colonic transcriptome	541:565	the colonic transcriptome after antibiotic treatment	541:592	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	3	22	theme	ITFs	443:446	arg1	supplementation					448:462	ITFs supplementation	443:462	ITFs supplementation	443:462	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	7	23	theme	selective	1223:1231	arg1	blooms					1233:1238	selective blooms	1223:1238	selective blooms of some opportunistic pathogens	1223:1270	ITFs supplementation increased the relative abundance of some beneficial bacteria and butyrate levels, but resulted in selective blooms of some opportunistic pathogens and elevated the pathways associated with diseases linked to gut microbiota function.
32813896	10	24	theme	STUDY	1829:1833	arg1	SIGNIFICANCE					1798:1809	SIGNIFICANCE	1798:1809	SIGNIFICANCE	1798:1809	SIGNIFICANCE AND IMPACT OF THE STUDY These findings highlighted that caution is required when supplementing ITFs to restore intestinal homeostasis in the context of dysbiosis resulting from broad-spectrum antibiotics.
32813896	10	24	theme	STUDY	1829:1833	arg1	IMPACT					1815:1820	IMPACT	1815:1820	IMPACT	1815:1820	SIGNIFICANCE AND IMPACT OF THE STUDY These findings highlighted that caution is required when supplementing ITFs to restore intestinal homeostasis in the context of dysbiosis resulting from broad-spectrum antibiotics.
32813896	9	25	theme	post-antibiotic	1650:1664	arg1	consumption					1671:1681	post-antibiotic ITFs consumption	1650:1681	post-antibiotic ITFs consumption	1650:1681	CONCLUSION These data showed that post-antibiotic ITFs consumption did not always lead to beneficial effects but might lead to potential adverse effects in the context of dysbiosis.
32813896	4	26	dep	reconstituted	733:745	arg1	supplementation					781:795	ITFs supplementation	776:795	ITFs supplementation (5%) for 14 days	776:812	METHODS AND RESULTS Male BALB/c mice were subjected to an antibiotic cocktail (ABx) treatment for 7 days, and their microbiomes were then reconstituted either spontaneously or with ITFs supplementation (5%) for 14 days.
32813896	4	26	dep	reconstituted	733:745	arg1	either					747:752	either	747:752	either	747:752	METHODS AND RESULTS Male BALB/c mice were subjected to an antibiotic cocktail (ABx) treatment for 7 days, and their microbiomes were then reconstituted either spontaneously or with ITFs supplementation (5%) for 14 days.
32813896	4	26	dep	reconstituted	733:745	arg1	%					799:799	5%	798:799	5%	798:799	METHODS AND RESULTS Male BALB/c mice were subjected to an antibiotic cocktail (ABx) treatment for 7 days, and their microbiomes were then reconstituted either spontaneously or with ITFs supplementation (5%) for 14 days.
32813896	7	27	theme	gut	1333:1335	arg1	function					1348:1355	gut microbiota function	1333:1355	gut microbiota function	1333:1355	ITFs supplementation increased the relative abundance of some beneficial bacteria and butyrate levels, but resulted in selective blooms of some opportunistic pathogens and elevated the pathways associated with diseases linked to gut microbiota function.
32813896	3	28	theme	present	395:401	arg1	study					403:407	the present study	391:407	the present study	391:407	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	9	29	theme	ITFs	1666:1669	arg1	consumption					1671:1681	post-antibiotic ITFs consumption	1650:1681	post-antibiotic ITFs consumption	1650:1681	CONCLUSION These data showed that post-antibiotic ITFs consumption did not always lead to beneficial effects but might lead to potential adverse effects in the context of dysbiosis.
32813896	7	30	theme	relative	1139:1146	arg1	abundance					1148:1156	the relative abundance	1135:1156	the relative abundance of some beneficial bacteria and butyrate levels	1135:1204	ITFs supplementation increased the relative abundance of some beneficial bacteria and butyrate levels, but resulted in selective blooms of some opportunistic pathogens and elevated the pathways associated with diseases linked to gut microbiota function.
32813896	5	31	theme	antibiotic-induced	881:898	arg1	colitis					900:906	antibiotic-induced colitis	881:906	antibiotic-induced colitis	881:906	Our data showed that ITFs supplementation delayed the recovery of antibiotic-induced colitis compared with the spontaneous recovery.
32813896	0	32	theme	prebiotic	15:23	arg1	fructans					37:44	the prebiotic inulin-type fructans	11:44	the prebiotic inulin-type fructans	11:44	Effects of the prebiotic inulin-type fructans on post-antibiotic reconstitution of the gut microbiome.
32813896	8	33	theme	ITFs	1363:1366	arg1	supplementation					1368:1382	ITFs supplementation	1363:1382	ITFs supplementation	1363:1382	Both ITFs supplementation and spontaneous recovery could restore the colonic transcriptome nearly to the initial profile to a certain extent; however, ITFs supplementation delayed the restoration of the immunoglobulin genes compared to spontaneous recovery.
32813896	2	34	theme	post-antibiotic	295:309	arg1	reconstitution					311:324	post-antibiotic reconstitution	295:324	post-antibiotic reconstitution of the gut microbiome	295:346	However, the impacts of ITFs on post-antibiotic reconstitution of the gut microbiome remain incompletely understood.
32813896	3	35	theme	intestinal	467:476	arg1	inflammation					478:489	intestinal inflammation	467:489	intestinal inflammation	467:489	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	10	36	theme	dysbiosis	1963:1971	arg1	context					1952:1958	the context	1948:1958	the context of dysbiosis resulting from broad-spectrum antibiotics	1948:2013	SIGNIFICANCE AND IMPACT OF THE STUDY These findings highlighted that caution is required when supplementing ITFs to restore intestinal homeostasis in the context of dysbiosis resulting from broad-spectrum antibiotics.
32813896	4	37	theme	METHODS	595:601	arg1	mice					627:630	METHODS AND RESULTS Male BALB/c mice	595:630	METHODS AND RESULTS Male BALB/c mice	595:630	METHODS AND RESULTS Male BALB/c mice were subjected to an antibiotic cocktail (ABx) treatment for 7 days, and their microbiomes were then reconstituted either spontaneously or with ITFs supplementation (5%) for 14 days.
32813896	8	38	theme	ITFs	1509:1512	arg1	supplementation					1514:1528	ITFs supplementation	1509:1528	ITFs supplementation	1509:1528	Both ITFs supplementation and spontaneous recovery could restore the colonic transcriptome nearly to the initial profile to a certain extent; however, ITFs supplementation delayed the restoration of the immunoglobulin genes compared to spontaneous recovery.
32813896	10	39	dep	SIGNIFICANCE	1798:1809	arg1	findings					1841:1848	These findings	1835:1848	SIGNIFICANCE AND IMPACT OF THE STUDY These findings	1798:1848	SIGNIFICANCE AND IMPACT OF THE STUDY These findings highlighted that caution is required when supplementing ITFs to restore intestinal homeostasis in the context of dysbiosis resulting from broad-spectrum antibiotics.
32813896	1	40	theme	gut	204:206	arg1	composition					219:229	the gut microbiota composition	200:229	the gut microbiota composition	200:229	AIMS Interventions using prebiotic inulin-type fructans (ITFs) are widely prescribed to modulate the gut microbiota composition and activity to promote health.
32813896	0	41	theme	fructans	37:44	arg1	Effects					0:6	Effects	0:6	Effects of the prebiotic inulin-type fructans on post-antibiotic reconstitution of the gut	0:89	Effects of the prebiotic inulin-type fructans on post-antibiotic reconstitution of the gut microbiome.
32813896	2	42	theme	microbiome	337:346	arg1	reconstitution					311:324	post-antibiotic reconstitution	295:324	post-antibiotic reconstitution of the gut microbiome	295:346	However, the impacts of ITFs on post-antibiotic reconstitution of the gut microbiome remain incompletely understood.
32813896	1	43	theme	microbiota	208:217	arg1	composition					219:229	the gut microbiota composition	200:229	the gut microbiota composition	200:229	AIMS Interventions using prebiotic inulin-type fructans (ITFs) are widely prescribed to modulate the gut microbiota composition and activity to promote health.
32813896	3	44	theme	supplementation	448:462	arg1	effects					432:438	the effects	428:438	the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment	428:592	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	0	45	theme	inulin-type	25:35	arg1	fructans					37:44	the prebiotic inulin-type fructans	11:44	the prebiotic inulin-type fructans	11:44	Effects of the prebiotic inulin-type fructans on post-antibiotic reconstitution of the gut microbiome.
32813896	6	46	theme	spontaneous	981:991	arg1	recovery					993:1000	spontaneous recovery	981:1000	spontaneous recovery	981:1000	Neither ITFs supplementation nor spontaneous recovery could restore the microbial community composition at the genus level back to its initial composition.
32813896	7	47	theme	ITFs	1104:1107	arg1	supplementation					1109:1123	ITFs supplementation	1104:1123	ITFs supplementation	1104:1123	ITFs supplementation increased the relative abundance of some beneficial bacteria and butyrate levels, but resulted in selective blooms of some opportunistic pathogens and elevated the pathways associated with diseases linked to gut microbiota function.
32813896	4	48	theme	cocktail	664:671	arg1	treatment					679:687	an antibiotic cocktail (ABx) treatment	650:687	an antibiotic cocktail (ABx) treatment for 7 days	650:698	METHODS AND RESULTS Male BALB/c mice were subjected to an antibiotic cocktail (ABx) treatment for 7 days, and their microbiomes were then reconstituted either spontaneously or with ITFs supplementation (5%) for 14 days.
32813896	0	49	theme	post-antibiotic	49:63	arg1	reconstitution					65:78	post-antibiotic reconstitution	49:78	post-antibiotic reconstitution of the gut	49:89	Effects of the prebiotic inulin-type fructans on post-antibiotic reconstitution of the gut microbiome.
32813896	5	50	theme	colitis	900:906	arg1	recovery					869:876	the recovery	865:876	the recovery of antibiotic-induced colitis	865:906	Our data showed that ITFs supplementation delayed the recovery of antibiotic-induced colitis compared with the spontaneous recovery.
32813896	10	51	theme	broad-spectrum	1988:2001	arg1	antibiotics					2003:2013	broad-spectrum antibiotics	1988:2013	broad-spectrum antibiotics	1988:2013	SIGNIFICANCE AND IMPACT OF THE STUDY These findings highlighted that caution is required when supplementing ITFs to restore intestinal homeostasis in the context of dysbiosis resulting from broad-spectrum antibiotics.
32813896	8	52	theme	certain	1484:1490	arg1	extent					1492:1497	a certain extent	1482:1497	a certain extent	1482:1497	Both ITFs supplementation and spontaneous recovery could restore the colonic transcriptome nearly to the initial profile to a certain extent; however, ITFs supplementation delayed the restoration of the immunoglobulin genes compared to spontaneous recovery.
32813896	5	53	theme	spontaneous	926:936	arg1	recovery					938:945	the spontaneous recovery	922:945	the spontaneous recovery	922:945	Our data showed that ITFs supplementation delayed the recovery of antibiotic-induced colitis compared with the spontaneous recovery.
32813896	7	54	theme	levels	1199:1204	arg1	abundance					1148:1156	the relative abundance	1135:1156	the relative abundance of some beneficial bacteria and butyrate levels	1135:1204	ITFs supplementation increased the relative abundance of some beneficial bacteria and butyrate levels, but resulted in selective blooms of some opportunistic pathogens and elevated the pathways associated with diseases linked to gut microbiota function.
32813896	9	55	theme	dysbiosis	1787:1795	arg1	context					1776:1782	the context	1772:1782	the context of dysbiosis	1772:1795	CONCLUSION These data showed that post-antibiotic ITFs consumption did not always lead to beneficial effects but might lead to potential adverse effects in the context of dysbiosis.
32813896	9	56	theme	beneficial	1706:1715	arg1	effects					1717:1723	beneficial effects	1706:1723	beneficial effects	1706:1723	CONCLUSION These data showed that post-antibiotic ITFs consumption did not always lead to beneficial effects but might lead to potential adverse effects in the context of dysbiosis.
32813896	1	57	theme	prebiotic	128:136	arg1	ITFs					160:163	ITFs	160:163	ITFs	160:163	AIMS Interventions using prebiotic inulin-type fructans (ITFs) are widely prescribed to modulate the gut microbiota composition and activity to promote health.
32813896	1	57	theme	prebiotic	128:136	arg1	fructans					150:157	prebiotic inulin-type fructans	128:157	prebiotic inulin-type fructans (ITFs)	128:164	AIMS Interventions using prebiotic inulin-type fructans (ITFs) are widely prescribed to modulate the gut microbiota composition and activity to promote health.
32813896	2	58	from	impacts	276:282	arg1	reconstitution					311:324	post-antibiotic reconstitution	295:324	post-antibiotic reconstitution of the gut microbiome	295:346	However, the impacts of ITFs on post-antibiotic reconstitution of the gut microbiome remain incompletely understood.
32813896	6	59	theme	ITFs	956:959	arg1	supplementation					961:975	ITFs supplementation	956:975	ITFs supplementation	956:975	Neither ITFs supplementation nor spontaneous recovery could restore the microbial community composition at the genus level back to its initial composition.
32813896	1	60	theme	inulin-type	138:148	arg1	ITFs					160:163	ITFs	160:163	ITFs	160:163	AIMS Interventions using prebiotic inulin-type fructans (ITFs) are widely prescribed to modulate the gut microbiota composition and activity to promote health.
32813896	1	60	theme	inulin-type	138:148	arg1	fructans					150:157	prebiotic inulin-type fructans	128:157	prebiotic inulin-type fructans (ITFs)	128:164	AIMS Interventions using prebiotic inulin-type fructans (ITFs) are widely prescribed to modulate the gut microbiota composition and activity to promote health.
32813896	1	61	theme	AIMS	103:106	arg1	Interventions					108:120	AIMS Interventions	103:120	AIMS Interventions using prebiotic inulin-type fructans (ITFs)	103:164	AIMS Interventions using prebiotic inulin-type fructans (ITFs) are widely prescribed to modulate the gut microbiota composition and activity to promote health.
32813896	6	62	theme	community	1030:1038	arg1	composition					1040:1050	the microbial community composition	1016:1050	the microbial community composition	1016:1050	Neither ITFs supplementation nor spontaneous recovery could restore the microbial community composition at the genus level back to its initial composition.
32813896	8	63	theme	colonic	1427:1433	arg1	transcriptome					1435:1447	the colonic transcriptome	1423:1447	the colonic transcriptome	1423:1447	Both ITFs supplementation and spontaneous recovery could restore the colonic transcriptome nearly to the initial profile to a certain extent; however, ITFs supplementation delayed the restoration of the immunoglobulin genes compared to spontaneous recovery.
32813896	8	64	theme	immunoglobulin	1561:1574	arg1	genes					1576:1580	the immunoglobulin genes	1557:1580	the immunoglobulin genes	1557:1580	Both ITFs supplementation and spontaneous recovery could restore the colonic transcriptome nearly to the initial profile to a certain extent; however, ITFs supplementation delayed the restoration of the immunoglobulin genes compared to spontaneous recovery.
32813896	8	65	theme	spontaneous	1388:1398	arg1	recovery					1400:1407	spontaneous recovery	1388:1407	spontaneous recovery	1388:1407	Both ITFs supplementation and spontaneous recovery could restore the colonic transcriptome nearly to the initial profile to a certain extent; however, ITFs supplementation delayed the restoration of the immunoglobulin genes compared to spontaneous recovery.
32813896	4	66	dep	either	747:752	arg1	spontaneously					754:766	spontaneously	754:766	spontaneously	754:766	METHODS AND RESULTS Male BALB/c mice were subjected to an antibiotic cocktail (ABx) treatment for 7 days, and their microbiomes were then reconstituted either spontaneously or with ITFs supplementation (5%) for 14 days.
32813896	2	67	theme	gut	333:335	arg1	microbiome					337:346	the gut microbiome	329:346	the gut microbiome	329:346	However, the impacts of ITFs on post-antibiotic reconstitution of the gut microbiome remain incompletely understood.
32813896	8	68	theme	spontaneous	1594:1604	arg1	recovery					1606:1613	spontaneous recovery	1594:1613	spontaneous recovery	1594:1613	Both ITFs supplementation and spontaneous recovery could restore the colonic transcriptome nearly to the initial profile to a certain extent; however, ITFs supplementation delayed the restoration of the immunoglobulin genes compared to spontaneous recovery.
32813896	8	69	theme	initial	1463:1469	arg1	profile					1471:1477	the initial profile	1459:1477	the initial profile to a certain extent	1459:1497	Both ITFs supplementation and spontaneous recovery could restore the colonic transcriptome nearly to the initial profile to a certain extent; however, ITFs supplementation delayed the restoration of the immunoglobulin genes compared to spontaneous recovery.
32813896	3	70	from	effects	432:438	arg1	composition					496:506	the composition	492:506	the composition of the intestinal microbiota	492:535	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	3	70	from	effects	432:438	arg1	transcriptome					553:565	the colonic transcriptome	541:565	the colonic transcriptome after antibiotic treatment	541:592	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	3	70	from	effects	432:438	arg1	inflammation					478:489	intestinal inflammation	467:489	intestinal inflammation	467:489	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	3	71	theme	microbiota	526:535	arg1	transcriptome					553:565	the colonic transcriptome	541:565	the colonic transcriptome after antibiotic treatment	541:592	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	3	71	theme	microbiota	526:535	arg1	composition					496:506	the composition	492:506	the composition of the intestinal microbiota	492:535	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	3	71	theme	microbiota	526:535	arg1	inflammation					478:489	intestinal inflammation	467:489	intestinal inflammation	467:489	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	4	72	theme	ABx	674:676	arg1	treatment					679:687	an antibiotic cocktail (ABx) treatment	650:687	an antibiotic cocktail (ABx) treatment for 7 days	650:698	METHODS AND RESULTS Male BALB/c mice were subjected to an antibiotic cocktail (ABx) treatment for 7 days, and their microbiomes were then reconstituted either spontaneously or with ITFs supplementation (5%) for 14 days.
32813896	6	73	theme	genus	1059:1063	arg1	level					1065:1069	the genus level	1055:1069	the genus level	1055:1069	Neither ITFs supplementation nor spontaneous recovery could restore the microbial community composition at the genus level back to its initial composition.
32813896	3	74	theme	study	403:407	arg1	aim					384:386	The aim	380:386	The aim of the present study	380:407	The aim of the present study was to investigate the effects of ITFs supplementation on intestinal inflammation, the composition of the intestinal microbiota and the colonic transcriptome after antibiotic treatment.
32813896	7	75	attach	linked	1323:1328	arg1	function					1348:1355	gut microbiota function	1333:1355	gut microbiota function	1333:1355	ITFs supplementation increased the relative abundance of some beneficial bacteria and butyrate levels, but resulted in selective blooms of some opportunistic pathogens and elevated the pathways associated with diseases linked to gut microbiota function.
32813896	7	75	attach	linked	1323:1328	arg2	diseases					1314:1321	diseases	1314:1321	diseases linked to gut microbiota function	1314:1355	ITFs supplementation increased the relative abundance of some beneficial bacteria and butyrate levels, but resulted in selective blooms of some opportunistic pathogens and elevated the pathways associated with diseases linked to gut microbiota function.
32813896	4	76	theme	antibiotic	653:662	arg1	treatment					679:687	an antibiotic cocktail (ABx) treatment	650:687	an antibiotic cocktail (ABx) treatment for 7 days	650:698	METHODS AND RESULTS Male BALB/c mice were subjected to an antibiotic cocktail (ABx) treatment for 7 days, and their microbiomes were then reconstituted either spontaneously or with ITFs supplementation (5%) for 14 days.
32813896	10	77	theme	intestinal	1922:1931	arg1	homeostasis					1933:1943	intestinal homeostasis	1922:1943	intestinal homeostasis	1922:1943	SIGNIFICANCE AND IMPACT OF THE STUDY These findings highlighted that caution is required when supplementing ITFs to restore intestinal homeostasis in the context of dysbiosis resulting from broad-spectrum antibiotics.
32813896	9	78	dep	CONCLUSION	1616:1625	arg1	showed					1638:1643	showed	1638:1643	showed that post-antibiotic ITFs consumption did not always lead to beneficial effects but might lead to potential adverse effects in the context of dysbiosis	1638:1795	CONCLUSION These data showed that post-antibiotic ITFs consumption did not always lead to beneficial effects but might lead to potential adverse effects in the context of dysbiosis.
32813896	9	79	from	effects	1761:1767	arg1	context					1776:1782	the context	1772:1782	the context of dysbiosis	1772:1795	CONCLUSION These data showed that post-antibiotic ITFs consumption did not always lead to beneficial effects but might lead to potential adverse effects in the context of dysbiosis.
33655745	2	0	theme	dopamine-grafted	484:499	arg1	OCMC-DA					535:541	OCMC-DA	535:541	OCMC-DA	535:541	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	0	theme	dopamine-grafted	484:499	arg1	cellulose					524:532	dopamine-grafted oxidized carboxymethyl cellulose	484:532	dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA)	484:542	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	6	1	theme	NEO	1309:1311	arg1	release					1298:1304	the controllable release	1281:1304	the controllable release of NEO for steady availability of the antibiotic on the wound location	1281:1375	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	4	2	with	endowed	922:928	arg1	stretchability					983:996	stretchability	983:996	stretchability (3300%)	983:1004	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	4	2	with	endowed	922:928	arg1	%					1003:1003	3300%	999:1003	3300%	999:1003	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	4	2	with	endowed	922:928	arg1	ability					971:977	excellent self-healing ability	948:977	excellent self-healing ability	948:977	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	6	3	from	location	1368:1375	arg1	availability					1324:1335	steady availability	1317:1335	steady availability of the antibiotic on the wound location	1317:1375	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	0	4	theme	Wound	110:114	arg1	Dressing					116:123	Rapid Self-Healing Wound Dressing	91:123	Rapid Self-Healing Wound Dressing	91:123	Antimicrobial/Biocompatible Hydrogels Dual-Reinforced by Cellulose as Ultrastretchable and Rapid Self-Healing Wound Dressing.
33655745	1	5	theme	rapid	194:198	arg1	self-healing					200:211	rapid self-healing	194:211	rapid self-healing	194:211	Hydrogels as a wound dressing, integrated with ultrastretchability, rapid self-healing, and excellent antimicrobial activity, are in high demand, particularly for joint skin wound healing.
33655745	3	6	theme	hydrogel	686:693	arg1	network					695:701	the hydrogel network	682:701	the hydrogel network	682:701	Moreover, neomycin (NEO), an aminoglycoside antibiotic with multifunctional groups, was incorporated into the hydrogel network as both an antibacterial agent and a cross-linker.
33655745	4	7	theme	dynamic	860:866	arg1	linkages					888:895	dynamic cross-linking imine linkages	860:895	dynamic cross-linking imine linkages between NEO and OCMC-DA	860:919	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	4	8	theme	dynamic	758:764	arg1	linkages					790:797	dynamic reversible borate ester linkages	758:797	dynamic reversible borate ester linkages	758:797	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	7	9	theme	rapid	1419:1423	arg1	properties					1462:1471	rapid self-healing and reliable mechanical properties	1419:1471	rapid self-healing and reliable mechanical properties	1419:1471	Overall, the antimicrobial hydrogel with rapid self-healing and reliable mechanical properties holds significant promise as dressing material for wound healing.
33655745	1	10	theme	joint	289:293	arg1	healing					306:312	joint skin wound healing	289:312	joint skin wound healing	289:312	Hydrogels as a wound dressing, integrated with ultrastretchability, rapid self-healing, and excellent antimicrobial activity, are in high demand, particularly for joint skin wound healing.
33655745	3	11	theme	antibacterial	714:726	arg1	neomycin					586:593	neomycin	586:593	neomycin (NEO)	586:599	Moreover, neomycin (NEO), an aminoglycoside antibiotic with multifunctional groups, was incorporated into the hydrogel network as both an antibacterial agent and a cross-linker.
33655745	3	11	theme	antibacterial	714:726	arg1	agent					728:732	an antibacterial agent	711:732	an antibacterial agent	711:732	Moreover, neomycin (NEO), an aminoglycoside antibiotic with multifunctional groups, was incorporated into the hydrogel network as both an antibacterial agent and a cross-linker.
33655745	6	12	theme	broad	1230:1234	arg1	spectrum					1236:1243	a broad spectrum	1228:1243	a broad spectrum	1228:1243	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	6	13	theme	controllable	1285:1296	arg1	release					1298:1304	the controllable release	1281:1304	the controllable release of NEO for steady availability of the antibiotic on the wound location	1281:1375	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	4	14	theme	self-healing	958:969	arg1	ability					971:977	excellent self-healing ability	948:977	excellent self-healing ability	948:977	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	1	15	theme	skin	295:298	arg1	healing					306:312	joint skin wound healing	289:312	joint skin wound healing	289:312	Hydrogels as a wound dressing, integrated with ultrastretchability, rapid self-healing, and excellent antimicrobial activity, are in high demand, particularly for joint skin wound healing.
33655745	7	16	theme	dressing	1502:1509	arg1	material					1511:1518	dressing material	1502:1518	dressing material for wound healing	1502:1536	Overall, the antimicrobial hydrogel with rapid self-healing and reliable mechanical properties holds significant promise as dressing material for wound healing.
33655745	4	17	theme	borate	777:782	arg1	linkages					790:797	dynamic reversible borate ester linkages	758:797	dynamic reversible borate ester linkages	758:797	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	6	18	theme	wound	1362:1366	arg1	location					1368:1375	the wound location	1358:1375	the wound location	1358:1375	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	7	19	theme	significant	1479:1489	arg1	promise					1491:1497	significant promise	1479:1497	significant promise	1479:1497	Overall, the antimicrobial hydrogel with rapid self-healing and reliable mechanical properties holds significant promise as dressing material for wound healing.
33655745	6	20	theme	composite	1118:1126	arg1	pH-responsive					1192:1204	pH-responsive	1192:1204	pH-responsive	1192:1204	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	6	20	theme	composite	1118:1126	arg1	hydrogel					1128:1135	the composite hydrogel	1114:1135	the composite hydrogel with improved biodegradability and biocompatibility	1114:1187	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	4	21	theme	reversible	766:775	arg1	linkages					790:797	dynamic reversible borate ester linkages	758:797	dynamic reversible borate ester linkages	758:797	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	0	22	theme	Self-Healing	97:108	arg1	Dressing					116:123	Rapid Self-Healing Wound Dressing	91:123	Rapid Self-Healing Wound Dressing	91:123	Antimicrobial/Biocompatible Hydrogels Dual-Reinforced by Cellulose as Ultrastretchable and Rapid Self-Healing Wound Dressing.
33655745	7	23	theme	self-healing	1425:1436	arg1	properties					1462:1471	rapid self-healing and reliable mechanical properties	1419:1471	rapid self-healing and reliable mechanical properties	1419:1471	Overall, the antimicrobial hydrogel with rapid self-healing and reliable mechanical properties holds significant promise as dressing material for wound healing.
33655745	4	24	dep	linkages	790:797	arg1	The					754:756	The	754:756	The	754:756	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	6	25	theme	antibiotic	1344:1353	arg1	availability					1324:1335	steady availability	1317:1335	steady availability of the antibiotic on the wound location	1317:1375	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	1	26	theme	wound	300:304	arg1	healing					306:312	joint skin wound healing	289:312	joint skin wound healing	289:312	Hydrogels as a wound dressing, integrated with ultrastretchability, rapid self-healing, and excellent antimicrobial activity, are in high demand, particularly for joint skin wound healing.
33655745	2	27	theme	multifunctional	325:339	arg1	hydrogel					363:370	a multifunctional and ductile composite hydrogel	323:370	a multifunctional and ductile composite hydrogel	323:370	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	3	28	with	antibiotic	620:629	arg1	groups					652:657	multifunctional groups	636:657	multifunctional groups	636:657	Moreover, neomycin (NEO), an aminoglycoside antibiotic with multifunctional groups, was incorporated into the hydrogel network as both an antibacterial agent and a cross-linker.
33655745	2	29	theme	vinyl	397:401	arg1	poly					392:395	poly	392:395	poly(vinyl alcohol) (PVA)-borax gel	392:426	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	29	theme	vinyl	397:401	arg1	alcohol					403:409	vinyl alcohol	397:409	vinyl alcohol	397:409	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	5	30	theme	as-reinforced	1011:1023	arg1	networks					1025:1032	The as-reinforced networks	1007:1032	The as-reinforced networks	1007:1032	The as-reinforced networks enhanced the mechanical properties of hydrogels significantly.
33655745	1	31	theme	antimicrobial	228:240	arg1	activity					242:249	excellent antimicrobial activity	218:249	excellent antimicrobial activity	218:249	Hydrogels as a wound dressing, integrated with ultrastretchability, rapid self-healing, and excellent antimicrobial activity, are in high demand, particularly for joint skin wound healing.
33655745	7	32	theme	reliable	1442:1449	arg1	properties					1462:1471	rapid self-healing and reliable mechanical properties	1419:1471	rapid self-healing and reliable mechanical properties	1419:1471	Overall, the antimicrobial hydrogel with rapid self-healing and reliable mechanical properties holds significant promise as dressing material for wound healing.
33655745	3	33	theme	multifunctional	636:650	arg1	groups					652:657	multifunctional groups	636:657	multifunctional groups	636:657	Moreover, neomycin (NEO), an aminoglycoside antibiotic with multifunctional groups, was incorporated into the hydrogel network as both an antibacterial agent and a cross-linker.
33655745	6	34	theme	improved	1142:1149	arg1	biodegradability					1151:1166	improved biodegradability	1142:1166	improved biodegradability	1142:1166	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	2	35	theme	-borax	417:422	arg1	matrix					433:438	a matrix	431:438	a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF)	431:573	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	35	theme	-borax	417:422	arg1	synergized					449:458	synergized	449:458	synergized	449:458	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	35	theme	-borax	417:422	arg1	gel					424:426	poly(vinyl alcohol) (PVA)-borax gel	392:426	poly(vinyl alcohol) (PVA)-borax gel	392:426	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	36	theme	cellulose	548:556	arg1	nanofibers					558:567	cellulose nanofibers	548:567	cellulose nanofibers (CNF)	548:573	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	36	theme	cellulose	548:556	arg1	CNF					570:572	CNF	570:572	CNF	570:572	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	7	37	theme	antimicrobial	1391:1403	arg1	hydrogel					1405:1412	the antimicrobial hydrogel	1387:1412	the antimicrobial hydrogel with rapid self-healing and reliable mechanical properties	1387:1471	Overall, the antimicrobial hydrogel with rapid self-healing and reliable mechanical properties holds significant promise as dressing material for wound healing.
33655745	1	38	theme	excellent	218:226	arg1	activity					242:249	excellent antimicrobial activity	218:249	excellent antimicrobial activity	218:249	Hydrogels as a wound dressing, integrated with ultrastretchability, rapid self-healing, and excellent antimicrobial activity, are in high demand, particularly for joint skin wound healing.
33655745	5	39	theme	hydrogels	1072:1080	arg1	properties					1058:1067	the mechanical properties	1043:1067	the mechanical properties of hydrogels	1043:1080	The as-reinforced networks enhanced the mechanical properties of hydrogels significantly.
33655745	7	40	with	hydrogel	1405:1412	arg1	properties					1462:1471	rapid self-healing and reliable mechanical properties	1419:1471	rapid self-healing and reliable mechanical properties	1419:1471	Overall, the antimicrobial hydrogel with rapid self-healing and reliable mechanical properties holds significant promise as dressing material for wound healing.
33655745	4	41	dep	along	849:853	arg1	with					855:858	with	855:858	with	855:858	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	4	42	theme	imine	882:886	arg1	linkages					888:895	dynamic cross-linking imine linkages	860:895	dynamic cross-linking imine linkages between NEO and OCMC-DA	860:919	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	0	43	theme	Rapid	91:95	arg1	Dressing					116:123	Rapid Self-Healing Wound Dressing	91:123	Rapid Self-Healing Wound Dressing	91:123	Antimicrobial/Biocompatible Hydrogels Dual-Reinforced by Cellulose as Ultrastretchable and Rapid Self-Healing Wound Dressing.
33655745	6	44	theme	bacteria	1248:1255	arg1	spectrum					1236:1243	a broad spectrum	1228:1243	a broad spectrum	1228:1243	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	1	45	theme	wound	141:145	arg1	dressing					147:154	a wound dressing	139:154	a wound dressing	139:154	Hydrogels as a wound dressing, integrated with ultrastretchability, rapid self-healing, and excellent antimicrobial activity, are in high demand, particularly for joint skin wound healing.
33655745	6	46	with	hydrogel	1128:1135	arg1	biocompatibility					1172:1187	biocompatibility	1172:1187	biocompatibility	1172:1187	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	6	46	with	hydrogel	1128:1135	arg1	biodegradability					1151:1166	improved biodegradability	1142:1166	improved biodegradability	1142:1166	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	4	47	theme	cross-linking	868:880	arg1	linkages					888:895	dynamic cross-linking imine linkages	860:895	dynamic cross-linking imine linkages between NEO and OCMC-DA	860:919	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	4	48	theme	excellent	948:956	arg1	ability					971:977	excellent self-healing ability	948:977	excellent self-healing ability	948:977	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	6	49	from	availability	1324:1335	arg1	location					1368:1375	the wound location	1358:1375	the wound location	1358:1375	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	6	50	theme	steady	1317:1322	arg1	availability					1324:1335	steady availability	1317:1335	steady availability of the antibiotic on the wound location	1317:1375	More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location.
33655745	2	51	theme	composite	353:361	arg1	hydrogel					363:370	a multifunctional and ductile composite hydrogel	323:370	a multifunctional and ductile composite hydrogel	323:370	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	7	52	theme	mechanical	1451:1460	arg1	properties					1462:1471	rapid self-healing and reliable mechanical properties	1419:1471	rapid self-healing and reliable mechanical properties	1419:1471	Overall, the antimicrobial hydrogel with rapid self-healing and reliable mechanical properties holds significant promise as dressing material for wound healing.
33655745	4	53	theme	ester	784:788	arg1	linkages					790:797	dynamic reversible borate ester linkages	758:797	dynamic reversible borate ester linkages	758:797	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	2	54	theme	ductile	345:351	arg1	hydrogel					363:370	a multifunctional and ductile composite hydrogel	323:370	a multifunctional and ductile composite hydrogel	323:370	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	1	55	theme	high	259:262	arg1	demand					264:269	high demand	259:269	high demand	259:269	Hydrogels as a wound dressing, integrated with ultrastretchability, rapid self-healing, and excellent antimicrobial activity, are in high demand, particularly for joint skin wound healing.
33655745	2	56	theme	carboxymethyl	510:522	arg1	OCMC-DA					535:541	OCMC-DA	535:541	OCMC-DA	535:541	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	56	theme	carboxymethyl	510:522	arg1	cellulose					524:532	dopamine-grafted oxidized carboxymethyl cellulose	484:532	dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA)	484:542	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	5	57	theme	mechanical	1047:1056	arg1	properties					1058:1067	the mechanical properties	1043:1067	the mechanical properties of hydrogels	1043:1080	The as-reinforced networks enhanced the mechanical properties of hydrogels significantly.
33655745	4	58	theme	hydrogen	803:810	arg1	bonds					812:816	hydrogen bonds	803:816	hydrogen bonds	803:816	The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%).
33655745	2	59	theme	oxidized	501:508	arg1	OCMC-DA					535:541	OCMC-DA	535:541	OCMC-DA	535:541	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	59	theme	oxidized	501:508	arg1	cellulose					524:532	dopamine-grafted oxidized carboxymethyl cellulose	484:532	dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA)	484:542	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	7	60	theme	wound	1524:1528	arg1	healing					1530:1536	wound healing	1524:1536	wound healing	1524:1536	Overall, the antimicrobial hydrogel with rapid self-healing and reliable mechanical properties holds significant promise as dressing material for wound healing.
33655745	2	61	with	dual-reinforced	463:477	arg1	nanofibers					558:567	cellulose nanofibers	548:567	cellulose nanofibers (CNF)	548:573	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	61	with	dual-reinforced	463:477	arg1	OCMC-DA					535:541	OCMC-DA	535:541	OCMC-DA	535:541	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	61	with	dual-reinforced	463:477	arg1	CNF					570:572	CNF	570:572	CNF	570:572	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	61	with	dual-reinforced	463:477	arg1	cellulose					524:532	dopamine-grafted oxidized carboxymethyl cellulose	484:532	dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA)	484:542	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	62	theme	poly	392:395	arg1	matrix					433:438	a matrix	431:438	a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF)	431:573	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	62	theme	poly	392:395	arg1	synergized					449:458	synergized	449:458	synergized	449:458	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33655745	2	62	theme	poly	392:395	arg1	gel					424:426	poly(vinyl alcohol) (PVA)-borax gel	392:426	poly(vinyl alcohol) (PVA)-borax gel	392:426	Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF).
33595569	4	0	theme	oxidase	690:696	arg1	activity					706:713	the oxidase mimetic activity	686:713	the oxidase mimetic activity	686:713	This was attributed to the oxidase mimetic activity and the peroxidase mimicking activity of UiO-66-NH2.
33595569	1	1	theme	chitosan	274:281	arg1	matrix					288:293	a chitosan (CS) matrix	272:293	a chitosan (CS) matrix	272:293	In this study, UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities were incorporated into a chitosan (CS) matrix by a simple and environmentally friendly method.
33595569	0	2	theme	membrane	93:100	arg1	activities					45:54	UV-triggered oxidase mimetic activities	16:54	UV-triggered oxidase mimetic activities	16:54	Peroxidase- and UV-triggered oxidase mimetic activities of the UiO-66-NH2/chitosan composite membrane for antibacterial properties.
33595569	0	2	theme	membrane	93:100	arg1	Peroxidase-					0:10	Peroxidase-	0:10	Peroxidase-	0:10	Peroxidase- and UV-triggered oxidase mimetic activities of the UiO-66-NH2/chitosan composite membrane for antibacterial properties.
33595569	1	3	theme	MOF	183:185	arg1	nanoparticles					188:200	UiO-66-NH2 metal-organic framework (MOF) nanoparticles	147:200	UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities	147:247	In this study, UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities were incorporated into a chitosan (CS) matrix by a simple and environmentally friendly method.
33595569	6	4	theme	reactive	1008:1015	arg1	species					1024:1030	reactive oxygen species	1008:1030	reactive oxygen species generation tests	1008:1047	The antibacterial mechanism was further proved by antibacterial experiments, TMB·2HCl color development experiments, reactive oxygen species generation tests and electron spin resonance tests.
33595569	6	5	theme	antibacterial	895:907	arg1	mechanism					909:917	The antibacterial mechanism	891:917	The antibacterial mechanism	891:917	The antibacterial mechanism was further proved by antibacterial experiments, TMB·2HCl color development experiments, reactive oxygen species generation tests and electron spin resonance tests.
33595569	7	6	theme	in	1131:1132	arg1	dressing					1121:1128	a potential medical antibacterial dressing	1087:1128	a potential medical antibacterial dressing	1087:1128	As a potential medical antibacterial dressing, in vitro membranes were also investigated.
33595569	7	6	theme	in	1131:1132	arg1	membranes					1140:1148	in vitro membranes	1131:1148	in vitro membranes	1131:1148	As a potential medical antibacterial dressing, in vitro membranes were also investigated.
33595569	3	7	theme	UV	533:534	arg1	pre-irradiation					536:550	UV pre-irradiation	533:550	UV pre-irradiation of the UiO-66-NH2/CS composite membrane	533:590	Intriguingly, 30 min of UV pre-irradiation of the UiO-66-NH2/CS composite membrane, in the absence of H2O2, still leads to a good antibacterial activity.
33595569	3	8	theme	UiO-66-NH2/CS	559:571	arg1	membrane					583:590	the UiO-66-NH2/CS composite membrane	555:590	the UiO-66-NH2/CS composite membrane	555:590	Intriguingly, 30 min of UV pre-irradiation of the UiO-66-NH2/CS composite membrane, in the absence of H2O2, still leads to a good antibacterial activity.
33595569	0	9	theme	antibacterial	106:118	arg1	properties					120:129	antibacterial properties	106:129	antibacterial properties	106:129	Peroxidase- and UV-triggered oxidase mimetic activities of the UiO-66-NH2/chitosan composite membrane for antibacterial properties.
33595569	3	10	theme	composite	573:581	arg1	membrane					583:590	the UiO-66-NH2/CS composite membrane	555:590	the UiO-66-NH2/CS composite membrane	555:590	Intriguingly, 30 min of UV pre-irradiation of the UiO-66-NH2/CS composite membrane, in the absence of H2O2, still leads to a good antibacterial activity.
33595569	4	11	theme	peroxidase	723:732	arg1	activity					744:751	the peroxidase mimicking activity	719:751	the peroxidase mimicking activity of UiO-66-NH2	719:765	This was attributed to the oxidase mimetic activity and the peroxidase mimicking activity of UiO-66-NH2.
33595569	4	12	theme	mimetic	698:704	arg1	activity					706:713	the oxidase mimetic activity	686:713	the oxidase mimetic activity	686:713	This was attributed to the oxidase mimetic activity and the peroxidase mimicking activity of UiO-66-NH2.
33595569	2	13	contain	possesses	381:389	arg2	activity					416:423	the peroxidase mimicking activity	391:423	the peroxidase mimicking activity in the presence of traces of H2O2	391:457	The UiO-66-NH2/CS composite membrane possesses the peroxidase mimicking activity in the presence of traces of H2O2, thus resulting in good antibacterial properties.
33595569	2	13	contain	possesses	381:389	arg1	membrane					372:379	The UiO-66-NH2/CS composite membrane	344:379	The UiO-66-NH2/CS composite membrane	344:379	The UiO-66-NH2/CS composite membrane possesses the peroxidase mimicking activity in the presence of traces of H2O2, thus resulting in good antibacterial properties.
33595569	1	14	theme	oxidase	222:228	arg1	activities					238:247	oxidase mimetic activities	222:247	oxidase mimetic activities	222:247	In this study, UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities were incorporated into a chitosan (CS) matrix by a simple and environmentally friendly method.
33595569	6	15	theme	resonance	1067:1075	arg1	tests					1077:1081	electron spin resonance tests	1053:1081	electron spin resonance tests	1053:1081	The antibacterial mechanism was further proved by antibacterial experiments, TMB·2HCl color development experiments, reactive oxygen species generation tests and electron spin resonance tests.
33595569	6	16	theme	oxygen	1017:1022	arg1	species					1024:1030	reactive oxygen species	1008:1030	reactive oxygen species generation tests	1008:1047	The antibacterial mechanism was further proved by antibacterial experiments, TMB·2HCl color development experiments, reactive oxygen species generation tests and electron spin resonance tests.
33595569	7	17	theme	potential	1089:1097	arg1	dressing					1121:1128	a potential medical antibacterial dressing	1087:1128	a potential medical antibacterial dressing	1087:1128	As a potential medical antibacterial dressing, in vitro membranes were also investigated.
33595569	7	17	theme	potential	1089:1097	arg1	membranes					1140:1148	in vitro membranes	1131:1148	in vitro membranes	1131:1148	As a potential medical antibacterial dressing, in vitro membranes were also investigated.
33595569	7	18	dep	in	1131:1132	arg1	vitro					1134:1138	vitro	1134:1138	vitro	1134:1138	As a potential medical antibacterial dressing, in vitro membranes were also investigated.
33595569	3	19	theme	pre-irradiation	536:550	arg1	min					526:528	30 min	523:528	30 min of UV pre-irradiation of the UiO-66-NH2/CS composite membrane	523:590	Intriguingly, 30 min of UV pre-irradiation of the UiO-66-NH2/CS composite membrane, in the absence of H2O2, still leads to a good antibacterial activity.
33595569	7	20	theme	medical	1099:1105	arg1	dressing					1121:1128	a potential medical antibacterial dressing	1087:1128	a potential medical antibacterial dressing	1087:1128	As a potential medical antibacterial dressing, in vitro membranes were also investigated.
33595569	7	20	theme	medical	1099:1105	arg1	membranes					1140:1148	in vitro membranes	1131:1148	in vitro membranes	1131:1148	As a potential medical antibacterial dressing, in vitro membranes were also investigated.
33595569	5	21	theme	direct	803:808	arg1	exposure					810:817	direct exposure	803:817	direct exposure to UV irradiation and H2O2	803:844	In such a way, the side effects of direct exposure to UV irradiation and H2O2 can be avoided for wound-healing treatments.
33595569	6	22	theme	development	983:993	arg1	experiments					995:1005	TMB·2HCl color development experiments	968:1005	TMB·2HCl color development experiments	968:1005	The antibacterial mechanism was further proved by antibacterial experiments, TMB·2HCl color development experiments, reactive oxygen species generation tests and electron spin resonance tests.
33595569	7	23	theme	antibacterial	1107:1119	arg1	dressing					1121:1128	a potential medical antibacterial dressing	1087:1128	a potential medical antibacterial dressing	1087:1128	As a potential medical antibacterial dressing, in vitro membranes were also investigated.
33595569	7	23	theme	antibacterial	1107:1119	arg1	membranes					1140:1148	in vitro membranes	1131:1148	in vitro membranes	1131:1148	As a potential medical antibacterial dressing, in vitro membranes were also investigated.
33595569	2	24	theme	mimicking	406:414	arg1	activity					416:423	the peroxidase mimicking activity	391:423	the peroxidase mimicking activity in the presence of traces of H2O2	391:457	The UiO-66-NH2/CS composite membrane possesses the peroxidase mimicking activity in the presence of traces of H2O2, thus resulting in good antibacterial properties.
33595569	0	25	theme	oxidase	29:35	arg1	activities					45:54	UV-triggered oxidase mimetic activities	16:54	UV-triggered oxidase mimetic activities	16:54	Peroxidase- and UV-triggered oxidase mimetic activities of the UiO-66-NH2/chitosan composite membrane for antibacterial properties.
33595569	6	26	theme	color	977:981	arg1	experiments					995:1005	TMB·2HCl color development experiments	968:1005	TMB·2HCl color development experiments	968:1005	The antibacterial mechanism was further proved by antibacterial experiments, TMB·2HCl color development experiments, reactive oxygen species generation tests and electron spin resonance tests.
33595569	3	27	theme	membrane	583:590	arg1	pre-irradiation					536:550	UV pre-irradiation	533:550	UV pre-irradiation of the UiO-66-NH2/CS composite membrane	533:590	Intriguingly, 30 min of UV pre-irradiation of the UiO-66-NH2/CS composite membrane, in the absence of H2O2, still leads to a good antibacterial activity.
33595569	5	28	theme	UV	822:823	arg1	irradiation					825:835	UV irradiation	822:835	UV irradiation	822:835	In such a way, the side effects of direct exposure to UV irradiation and H2O2 can be avoided for wound-healing treatments.
33595569	0	29	theme	UV-triggered	16:27	arg1	activities					45:54	UV-triggered oxidase mimetic activities	16:54	UV-triggered oxidase mimetic activities	16:54	Peroxidase- and UV-triggered oxidase mimetic activities of the UiO-66-NH2/chitosan composite membrane for antibacterial properties.
33595569	6	30	theme	TMB·2HCl	968:975	arg1	experiments					995:1005	TMB·2HCl color development experiments	968:1005	TMB·2HCl color development experiments	968:1005	The antibacterial mechanism was further proved by antibacterial experiments, TMB·2HCl color development experiments, reactive oxygen species generation tests and electron spin resonance tests.
33595569	2	31	theme	peroxidase	395:404	arg1	activity					416:423	the peroxidase mimicking activity	391:423	the peroxidase mimicking activity in the presence of traces of H2O2	391:457	The UiO-66-NH2/CS composite membrane possesses the peroxidase mimicking activity in the presence of traces of H2O2, thus resulting in good antibacterial properties.
33595569	4	32	theme	UiO-66-NH2	756:765	arg1	activity					744:751	the peroxidase mimicking activity	719:751	the peroxidase mimicking activity of UiO-66-NH2	719:765	This was attributed to the oxidase mimetic activity and the peroxidase mimicking activity of UiO-66-NH2.
33595569	4	32	theme	UiO-66-NH2	756:765	arg1	activity					706:713	the oxidase mimetic activity	686:713	the oxidase mimetic activity	686:713	This was attributed to the oxidase mimetic activity and the peroxidase mimicking activity of UiO-66-NH2.
33595569	5	33	theme	wound-healing	865:877	arg1	treatments					879:888	wound-healing treatments	865:888	wound-healing treatments	865:888	In such a way, the side effects of direct exposure to UV irradiation and H2O2 can be avoided for wound-healing treatments.
33595569	2	34	theme	traces	444:449	arg1	presence					432:439	the presence	428:439	the presence of traces of H2O2	428:457	The UiO-66-NH2/CS composite membrane possesses the peroxidase mimicking activity in the presence of traces of H2O2, thus resulting in good antibacterial properties.
33595569	1	35	theme	simple	300:305	arg1	method					336:341	a simple and environmentally friendly method	298:341	a simple and environmentally friendly method	298:341	In this study, UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities were incorporated into a chitosan (CS) matrix by a simple and environmentally friendly method.
33595569	6	36	theme	spin	1062:1065	arg1	resonance					1067:1075	electron spin resonance	1053:1075	electron spin resonance tests	1053:1081	The antibacterial mechanism was further proved by antibacterial experiments, TMB·2HCl color development experiments, reactive oxygen species generation tests and electron spin resonance tests.
33595569	3	37	theme	H2O2	611:614	arg1	absence					600:606	the absence	596:606	the absence of H2O2	596:614	Intriguingly, 30 min of UV pre-irradiation of the UiO-66-NH2/CS composite membrane, in the absence of H2O2, still leads to a good antibacterial activity.
33595569	1	38	theme	mimetic	230:236	arg1	activities					238:247	oxidase mimetic activities	222:247	oxidase mimetic activities	222:247	In this study, UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities were incorporated into a chitosan (CS) matrix by a simple and environmentally friendly method.
33595569	0	39	theme	mimetic	37:43	arg1	activities					45:54	UV-triggered oxidase mimetic activities	16:54	UV-triggered oxidase mimetic activities	16:54	Peroxidase- and UV-triggered oxidase mimetic activities of the UiO-66-NH2/chitosan composite membrane for antibacterial properties.
33595569	2	40	theme	antibacterial	483:495	arg1	properties					497:506	good antibacterial properties	478:506	good antibacterial properties	478:506	The UiO-66-NH2/CS composite membrane possesses the peroxidase mimicking activity in the presence of traces of H2O2, thus resulting in good antibacterial properties.
33595569	3	41	theme	good	634:637	arg1	activity					653:660	a good antibacterial activity	632:660	a good antibacterial activity	632:660	Intriguingly, 30 min of UV pre-irradiation of the UiO-66-NH2/CS composite membrane, in the absence of H2O2, still leads to a good antibacterial activity.
33595569	5	42	theme	exposure	810:817	arg1	effects					792:798	the side effects	783:798	the side effects of direct exposure to UV irradiation and H2O2	783:844	In such a way, the side effects of direct exposure to UV irradiation and H2O2 can be avoided for wound-healing treatments.
33595569	2	43	from	activity	416:423	arg1	presence					432:439	the presence	428:439	the presence of traces of H2O2	428:457	The UiO-66-NH2/CS composite membrane possesses the peroxidase mimicking activity in the presence of traces of H2O2, thus resulting in good antibacterial properties.
33595569	6	44	theme	electron	1053:1060	arg1	resonance					1067:1075	electron spin resonance	1053:1075	electron spin resonance tests	1053:1081	The antibacterial mechanism was further proved by antibacterial experiments, TMB·2HCl color development experiments, reactive oxygen species generation tests and electron spin resonance tests.
33595569	2	45	theme	good	478:481	arg1	properties					497:506	good antibacterial properties	478:506	good antibacterial properties	478:506	The UiO-66-NH2/CS composite membrane possesses the peroxidase mimicking activity in the presence of traces of H2O2, thus resulting in good antibacterial properties.
33595569	1	46	theme	environmentally	311:325	arg1	method					336:341	a simple and environmentally friendly method	298:341	a simple and environmentally friendly method	298:341	In this study, UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities were incorporated into a chitosan (CS) matrix by a simple and environmentally friendly method.
33595569	3	47	theme	antibacterial	639:651	arg1	activity					653:660	a good antibacterial activity	632:660	a good antibacterial activity	632:660	Intriguingly, 30 min of UV pre-irradiation of the UiO-66-NH2/CS composite membrane, in the absence of H2O2, still leads to a good antibacterial activity.
33595569	2	48	theme	composite	362:370	arg1	membrane					372:379	The UiO-66-NH2/CS composite membrane	344:379	The UiO-66-NH2/CS composite membrane	344:379	The UiO-66-NH2/CS composite membrane possesses the peroxidase mimicking activity in the presence of traces of H2O2, thus resulting in good antibacterial properties.
33595569	1	49	theme	friendly	327:334	arg1	method					336:341	a simple and environmentally friendly method	298:341	a simple and environmentally friendly method	298:341	In this study, UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities were incorporated into a chitosan (CS) matrix by a simple and environmentally friendly method.
33595569	2	50	theme	UiO-66-NH2/CS	348:360	arg1	membrane					372:379	The UiO-66-NH2/CS composite membrane	344:379	The UiO-66-NH2/CS composite membrane	344:379	The UiO-66-NH2/CS composite membrane possesses the peroxidase mimicking activity in the presence of traces of H2O2, thus resulting in good antibacterial properties.
33595569	5	51	theme	side	787:790	arg1	effects					792:798	the side effects	783:798	the side effects of direct exposure to UV irradiation and H2O2	783:844	In such a way, the side effects of direct exposure to UV irradiation and H2O2 can be avoided for wound-healing treatments.
33595569	4	52	theme	mimicking	734:742	arg1	activity					744:751	the peroxidase mimicking activity	719:751	the peroxidase mimicking activity of UiO-66-NH2	719:765	This was attributed to the oxidase mimetic activity and the peroxidase mimicking activity of UiO-66-NH2.
33595569	1	53	with	nanoparticles	188:200	arg1	peroxidase					207:216	peroxidase	207:216	peroxidase	207:216	In this study, UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities were incorporated into a chitosan (CS) matrix by a simple and environmentally friendly method.
33595569	1	53	with	nanoparticles	188:200	arg1	activities					238:247	oxidase mimetic activities	222:247	oxidase mimetic activities	222:247	In this study, UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities were incorporated into a chitosan (CS) matrix by a simple and environmentally friendly method.
33595569	1	54	theme	UiO-66-NH2	147:156	arg1	nanoparticles					188:200	UiO-66-NH2 metal-organic framework (MOF) nanoparticles	147:200	UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities	147:247	In this study, UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities were incorporated into a chitosan (CS) matrix by a simple and environmentally friendly method.
33595569	0	55	theme	composite	83:91	arg1	membrane					93:100	the UiO-66-NH2/chitosan composite membrane	59:100	the UiO-66-NH2/chitosan composite membrane	59:100	Peroxidase- and UV-triggered oxidase mimetic activities of the UiO-66-NH2/chitosan composite membrane for antibacterial properties.
33595569	1	56	theme	metal-organic	158:170	arg1	nanoparticles					188:200	UiO-66-NH2 metal-organic framework (MOF) nanoparticles	147:200	UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities	147:247	In this study, UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities were incorporated into a chitosan (CS) matrix by a simple and environmentally friendly method.
33595569	6	57	theme	generation	1032:1041	arg1	tests					1043:1047	reactive oxygen species generation tests	1008:1047	reactive oxygen species generation tests	1008:1047	The antibacterial mechanism was further proved by antibacterial experiments, TMB·2HCl color development experiments, reactive oxygen species generation tests and electron spin resonance tests.
33595569	0	58	theme	UiO-66-NH2/chitosan	63:81	arg1	membrane					93:100	the UiO-66-NH2/chitosan composite membrane	59:100	the UiO-66-NH2/chitosan composite membrane	59:100	Peroxidase- and UV-triggered oxidase mimetic activities of the UiO-66-NH2/chitosan composite membrane for antibacterial properties.
33595569	2	59	theme	H2O2	454:457	arg1	traces					444:449	traces	444:449	traces of H2O2	444:457	The UiO-66-NH2/CS composite membrane possesses the peroxidase mimicking activity in the presence of traces of H2O2, thus resulting in good antibacterial properties.
33595569	1	60	theme	framework	172:180	arg1	nanoparticles					188:200	UiO-66-NH2 metal-organic framework (MOF) nanoparticles	147:200	UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities	147:247	In this study, UiO-66-NH2 metal-organic framework (MOF) nanoparticles with peroxidase and oxidase mimetic activities were incorporated into a chitosan (CS) matrix by a simple and environmentally friendly method.
33595569	6	61	theme	antibacterial	941:953	arg1	experiments					955:965	antibacterial experiments	941:965	antibacterial experiments	941:965	The antibacterial mechanism was further proved by antibacterial experiments, TMB·2HCl color development experiments, reactive oxygen species generation tests and electron spin resonance tests.
33595569	6	62	theme	species	1024:1030	arg1	generation					1032:1041	reactive oxygen species generation	1008:1041	reactive oxygen species generation tests	1008:1047	The antibacterial mechanism was further proved by antibacterial experiments, TMB·2HCl color development experiments, reactive oxygen species generation tests and electron spin resonance tests.
34314490	0	0	theme	glycoprotein-bound	96:113	arg1	tetrasaccharide					115:129	glycoprotein-bound tetrasaccharide	96:129	glycoprotein-bound tetrasaccharide	96:129	Revisiting N-glycosylation in Halobacterium salinarum: Characterizing a dolichol phosphate- and glycoprotein-bound tetrasaccharide.
34314490	6	1	theme	same	1292:1295	arg1	tetrasaccharide					1297:1311	the same tetrasaccharide	1288:1311	the same tetrasaccharide	1288:1311	When attached to dolichol phosphate but not to proteins, the same tetrasaccharide is methylated on the final sugar.
34314490	1	2	theme	N-glycosylation	195:209	arg1	example					184:190	the first example	174:190	the first example of N-glycosylation outside the Eukarya	174:229	Although Halobacterium salinarum provided the first example of N-glycosylation outside the Eukarya, much regarding such post-translational modification in this halophilic archaea remains either unclear or unknown.
34314490	0	3	from	N-glycosylation	11:25	arg1	salinarum					44:52	Halobacterium salinarum	30:52	Halobacterium salinarum	30:52	Revisiting N-glycosylation in Halobacterium salinarum: Characterizing a dolichol phosphate- and glycoprotein-bound tetrasaccharide.
34314490	6	4	theme	final	1334:1338	arg1	sugar					1340:1344	the final sugar	1330:1344	the final sugar	1330:1344	When attached to dolichol phosphate but not to proteins, the same tetrasaccharide is methylated on the final sugar.
34314490	4	5	theme	target	949:954	arg1	proteins					956:963	target proteins	949:963	target proteins	949:963	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	9	6	from	organism	1750:1757	arg1	delineation					1699:1709	delineation	1699:1709	delineation of the N-glycosylation pathway in this organism	1699:1757	salinarum, will allow delineation of the N-glycosylation pathway in this organism.
34314490	4	7	theme	proteins	956:963	arg1	residues					937:944	selected asparagine residues	917:944	selected asparagine residues of target proteins	917:963	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	4	7	theme	proteins	956:963	arg1	proteins					956:963	target proteins	949:963	target proteins	949:963	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	4	8	theme	mass	817:820	arg1	spectrometry					822:833	liquid chromatography-electrospray ionization mass spectrometry	771:833	liquid chromatography-electrospray ionization mass spectrometry	771:833	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	4	9	theme	ionization	806:815	arg1	spectrometry					822:833	liquid chromatography-electrospray ionization mass spectrometry	771:833	liquid chromatography-electrospray ionization mass spectrometry	771:833	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	5	10	theme	hexuronic	1160:1168	arg1	acid					1170:1173	a sulfated hexuronic acid	1149:1173	a sulfated hexuronic acid	1149:1173	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	5	10	theme	hexuronic	1160:1168	arg1	hexose					1141:1146	a hexose	1139:1146	a hexose	1139:1146	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	3	11	from	time	524:527	arg1	reports					506:512	reports	506:512	reports from that time on	506:530	Originally described some 40 years ago, reports from that time on have presented conflicted findings regarding the composition of this glycan, as well as differences between the protein-bound glycan and that version of the glycan attached to the lipid upon which it is assembled.
34314490	7	12	dep	phosphate-linked	1452:1467	arg1	tetrasaccharide					1495:1509	methylated and disulfated tetrasaccharide	1469:1509	methylated and disulfated tetrasaccharide	1469:1509	Moreover, in the absence of the oligosaccharyltransferase AglB, there is an accumulation of the dolichol phosphate-linked methylated and disulfated tetrasaccharide.
34314490	9	13	from	delineation	1699:1709	arg1	organism					1750:1757	this organism	1745:1757	this organism	1745:1757	salinarum, will allow delineation of the N-glycosylation pathway in this organism.
34314490	3	14	theme	conflicted	547:556	arg1	findings					558:565	conflicted findings	547:565	conflicted findings regarding the composition of this glycan	547:606	Originally described some 40 years ago, reports from that time on have presented conflicted findings regarding the composition of this glycan, as well as differences between the protein-bound glycan and that version of the glycan attached to the lipid upon which it is assembled.
34314490	3	15	theme	glycan	601:606	arg1	composition					581:591	the composition	577:591	the composition of this glycan	577:606	Originally described some 40 years ago, reports from that time on have presented conflicted findings regarding the composition of this glycan, as well as differences between the protein-bound glycan and that version of the glycan attached to the lipid upon which it is assembled.
34314490	5	16	theme	Such	1048:1051	arg1	efforts					1053:1059	Such efforts	1048:1059	Such efforts	1048:1059	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	7	17	theme	phosphate-linked	1452:1467	arg1	dolichol					1443:1450	the dolichol	1439:1450	the dolichol phosphate-linked methylated and disulfated tetrasaccharide	1439:1509	Moreover, in the absence of the oligosaccharyltransferase AglB, there is an accumulation of the dolichol phosphate-linked methylated and disulfated tetrasaccharide.
34314490	8	18	theme	approaches	1644:1653	arg1	availability					1614:1625	the availability	1610:1625	the availability of gene deletion approaches for manipulating Hbt	1610:1674	Knowing the composition of this glycan at both the lipid- and protein-bound stages, together with the availability of gene deletion approaches for manipulating Hbt.
34314490	4	19	theme	asparagine	926:935	arg1	residues					937:944	selected asparagine residues	917:944	selected asparagine residues of target proteins	917:963	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	4	19	theme	asparagine	926:935	arg1	proteins					956:963	target proteins	949:963	target proteins	949:963	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	2	20	theme	glycan	377:382	arg1	composition					350:360	The composition	346:360	The composition of an N-linked glycan decorating both the S-layer glycoprotein and archaellins	346:439	The composition of an N-linked glycan decorating both the S-layer glycoprotein and archaellins offers one such example.
34314490	2	21	theme	such	452:455	arg1	example					457:463	one such example	448:463	one such example	448:463	The composition of an N-linked glycan decorating both the S-layer glycoprotein and archaellins offers one such example.
34314490	5	22	link	N-linked	1074:1081	arg1	glycan					1083:1088	the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid	1070:1228	the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid	1070:1228	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	4	23	theme	selected	917:924	arg1	residues					937:944	selected asparagine residues	917:944	selected asparagine residues of target proteins	917:963	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	4	23	theme	selected	917:924	arg1	proteins					956:963	target proteins	949:963	target proteins	949:963	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	2	24	theme	N-linked	368:375	arg1	glycan					377:382	an N-linked glycan	365:382	an N-linked glycan decorating both the S-layer glycoprotein and archaellins	365:439	The composition of an N-linked glycan decorating both the S-layer glycoprotein and archaellins offers one such example.
34314490	9	25	theme	N-glycosylation	1718:1732	arg1	pathway					1734:1740	the N-glycosylation pathway	1714:1740	the N-glycosylation pathway in this organism	1714:1757	salinarum, will allow delineation of the N-glycosylation pathway in this organism.
34314490	0	26	theme	Halobacterium	30:42	arg1	salinarum					44:52	Halobacterium salinarum	30:52	Halobacterium salinarum	30:52	Revisiting N-glycosylation in Halobacterium salinarum: Characterizing a dolichol phosphate- and glycoprotein-bound tetrasaccharide.
34314490	7	27	theme	methylated	1469:1478	arg1	tetrasaccharide					1495:1509	methylated and disulfated tetrasaccharide	1469:1509	methylated and disulfated tetrasaccharide	1469:1509	Moreover, in the absence of the oligosaccharyltransferase AglB, there is an accumulation of the dolichol phosphate-linked methylated and disulfated tetrasaccharide.
34314490	4	28	theme	lipid	987:991	arg1	phosphate					1002:1010	the lipid dolichol phosphate	983:1010	the lipid dolichol phosphate upon which the glycan is assembled	983:1045	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	7	29	theme	AglB	1405:1408	arg1	absence					1364:1370	the absence	1360:1370	the absence of the oligosaccharyltransferase AglB	1360:1408	Moreover, in the absence of the oligosaccharyltransferase AglB, there is an accumulation of the dolichol phosphate-linked methylated and disulfated tetrasaccharide.
34314490	1	30	theme	regarding	237:245	arg1	modification					271:282	much regarding such post-translational modification	232:282	much regarding such post-translational modification in this halophilic archaea	232:309	Although Halobacterium salinarum provided the first example of N-glycosylation outside the Eukarya, much regarding such post-translational modification in this halophilic archaea remains either unclear or unknown.
34314490	4	31	theme	chromatography-electrospray	778:804	arg1	spectrometry					822:833	liquid chromatography-electrospray ionization mass spectrometry	771:833	liquid chromatography-electrospray ionization mass spectrometry	771:833	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	8	32	theme	gene	1630:1633	arg1	approaches					1644:1653	gene deletion approaches	1630:1653	gene deletion approaches for manipulating Hbt	1630:1674	Knowing the composition of this glycan at both the lipid- and protein-bound stages, together with the availability of gene deletion approaches for manipulating Hbt.
34314490	1	33	theme	Halobacterium	141:153	arg1	salinarum					155:163	Halobacterium salinarum	141:163	Halobacterium salinarum	141:163	Although Halobacterium salinarum provided the first example of N-glycosylation outside the Eukarya, much regarding such post-translational modification in this halophilic archaea remains either unclear or unknown.
34314490	1	34	theme	such	247:250	arg1	modification					271:282	much regarding such post-translational modification	232:282	much regarding such post-translational modification in this halophilic archaea	232:309	Although Halobacterium salinarum provided the first example of N-glycosylation outside the Eukarya, much regarding such post-translational modification in this halophilic archaea remains either unclear or unknown.
34314490	8	35	dep	stages	1588:1593	arg1	both					1554:1557	both	1554:1557	both	1554:1557	Knowing the composition of this glycan at both the lipid- and protein-bound stages, together with the availability of gene deletion approaches for manipulating Hbt.
34314490	2	36	gly	glycoprotein	412:423	arg1	glycoprotein					412:423	the S-layer glycoprotein	400:423	the S-layer glycoprotein	400:423	The composition of an N-linked glycan decorating both the S-layer glycoprotein and archaellins offers one such example.
34314490	4	37	theme	glycan	888:893	arg1	composition					868:878	the composition	864:878	the composition of this glycan	864:893	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	6	38	theme	dolichol	1248:1255	arg1	phosphate					1257:1265	dolichol phosphate	1248:1265	dolichol phosphate	1248:1265	When attached to dolichol phosphate but not to proteins, the same tetrasaccharide is methylated on the final sugar.
34314490	1	39	theme	post-translational	252:269	arg1	modification					271:282	much regarding such post-translational modification	232:282	much regarding such post-translational modification in this halophilic archaea	232:309	Although Halobacterium salinarum provided the first example of N-glycosylation outside the Eukarya, much regarding such post-translational modification in this halophilic archaea remains either unclear or unknown.
34314490	7	40	link	phosphate-linked	1452:1467	arg1	dolichol					1443:1450	the dolichol	1439:1450	the dolichol phosphate-linked methylated and disulfated tetrasaccharide	1439:1509	Moreover, in the absence of the oligosaccharyltransferase AglB, there is an accumulation of the dolichol phosphate-linked methylated and disulfated tetrasaccharide.
34314490	5	41	theme	second	1199:1204	arg1	acid					1225:1228	a second sulfated hexuronic acid	1197:1228	a second sulfated hexuronic acid	1197:1228	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	5	41	theme	second	1199:1204	arg1	hexose					1141:1146	a hexose	1139:1146	a hexose	1139:1146	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	4	42	theme	dolichol	993:1000	arg1	phosphate					1002:1010	the lipid dolichol phosphate	983:1010	the lipid dolichol phosphate upon which the glycan is assembled	983:1045	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	0	43	gly	N-glycosylation	11:25	arg1	salinarum					44:52	Halobacterium salinarum	30:52	Halobacterium salinarum	30:52	Revisiting N-glycosylation in Halobacterium salinarum: Characterizing a dolichol phosphate- and glycoprotein-bound tetrasaccharide.
34314490	9	44	from	pathway	1734:1740	arg1	organism					1750:1757	this organism	1745:1757	this organism	1745:1757	salinarum, will allow delineation of the N-glycosylation pathway in this organism.
34314490	5	45	theme	sulfated	1206:1213	arg1	acid					1225:1228	a second sulfated hexuronic acid	1197:1228	a second sulfated hexuronic acid	1197:1228	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	5	45	theme	sulfated	1206:1213	arg1	hexose					1141:1146	a hexose	1139:1146	a hexose	1139:1146	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	5	46	theme	sulfated	1151:1158	arg1	acid					1170:1173	a sulfated hexuronic acid	1149:1173	a sulfated hexuronic acid	1149:1173	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	5	46	theme	sulfated	1151:1158	arg1	hexose					1141:1146	a hexose	1139:1146	a hexose	1139:1146	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	3	47	theme	protein-bound	644:656	arg1	glycan					658:663	the protein-bound glycan	640:663	the protein-bound glycan	640:663	Originally described some 40 years ago, reports from that time on have presented conflicted findings regarding the composition of this glycan, as well as differences between the protein-bound glycan and that version of the glycan attached to the lipid upon which it is assembled.
34314490	1	48	from	modification	271:282	arg1	archaea					303:309	this halophilic archaea	287:309	this halophilic archaea	287:309	Although Halobacterium salinarum provided the first example of N-glycosylation outside the Eukarya, much regarding such post-translational modification in this halophilic archaea remains either unclear or unknown.
34314490	2	49	theme	S-layer	404:410	arg1	glycoprotein					412:423	the S-layer glycoprotein	400:423	the S-layer glycoprotein	400:423	The composition of an N-linked glycan decorating both the S-layer glycoprotein and archaellins offers one such example.
34314490	3	50	attach	attached	696:703	arg2	glycan					689:694	the glycan	685:694	the glycan attached to the lipid upon which it is assembled	685:743	Originally described some 40 years ago, reports from that time on have presented conflicted findings regarding the composition of this glycan, as well as differences between the protein-bound glycan and that version of the glycan attached to the lipid upon which it is assembled.
34314490	3	50	attach	attached	696:703	arg1	lipid					712:716	the lipid	708:716	the lipid upon which it is assembled	708:743	Originally described some 40 years ago, reports from that time on have presented conflicted findings regarding the composition of this glycan, as well as differences between the protein-bound glycan and that version of the glycan attached to the lipid upon which it is assembled.
34314490	5	51	theme	hexuronic	1215:1223	arg1	acid					1225:1228	a second sulfated hexuronic acid	1197:1228	a second sulfated hexuronic acid	1197:1228	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	5	51	theme	hexuronic	1215:1223	arg1	hexose					1141:1146	a hexose	1139:1146	a hexose	1139:1146	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	8	52	theme	lipid-	1563:1568	arg1	stages					1588:1593	both the lipid- and protein-bound stages	1554:1593	stages	1588:1593	Knowing the composition of this glycan at both the lipid- and protein-bound stages, together with the availability of gene deletion approaches for manipulating Hbt.
34314490	8	53	theme	glycan	1544:1549	arg1	composition					1524:1534	the composition	1520:1534	the composition of this glycan	1520:1549	Knowing the composition of this glycan at both the lipid- and protein-bound stages, together with the availability of gene deletion approaches for manipulating Hbt.
34314490	9	54	theme	pathway	1734:1740	arg1	delineation					1699:1709	delineation	1699:1709	delineation of the N-glycosylation pathway in this organism	1699:1757	salinarum, will allow delineation of the N-glycosylation pathway in this organism.
34314490	2	55	link	N-linked	368:375	arg1	glycan					377:382	an N-linked glycan	365:382	an N-linked glycan decorating both the S-layer glycoprotein and archaellins	365:439	The composition of an N-linked glycan decorating both the S-layer glycoprotein and archaellins offers one such example.
34314490	4	56	theme	liquid	771:776	arg1	spectrometry					822:833	liquid chromatography-electrospray ionization mass spectrometry	771:833	liquid chromatography-electrospray ionization mass spectrometry	771:833	To clarify these points, liquid chromatography-electrospray ionization mass spectrometry was employed here to revisit the composition of this glycan both when attached to selected asparagine residues of target proteins and when bound to the lipid dolichol phosphate upon which the glycan is assembled.
34314490	7	57	theme	dolichol	1443:1450	arg1	accumulation					1423:1434	an accumulation	1420:1434	an accumulation of the dolichol phosphate-linked methylated and disulfated tetrasaccharide	1420:1509	Moreover, in the absence of the oligosaccharyltransferase AglB, there is an accumulation of the dolichol phosphate-linked methylated and disulfated tetrasaccharide.
34314490	7	58	theme	disulfated	1484:1493	arg1	tetrasaccharide					1495:1509	methylated and disulfated tetrasaccharide	1469:1509	methylated and disulfated tetrasaccharide	1469:1509	Moreover, in the absence of the oligosaccharyltransferase AglB, there is an accumulation of the dolichol phosphate-linked methylated and disulfated tetrasaccharide.
34314490	3	59	theme	glycan	689:694	arg1	glycan					658:663	the protein-bound glycan	640:663	the protein-bound glycan	640:663	Originally described some 40 years ago, reports from that time on have presented conflicted findings regarding the composition of this glycan, as well as differences between the protein-bound glycan and that version of the glycan attached to the lipid upon which it is assembled.
34314490	3	59	theme	glycan	689:694	arg1	version					674:680	that version	669:680	that version of the glycan attached to the lipid upon which it is assembled	669:743	Originally described some 40 years ago, reports from that time on have presented conflicted findings regarding the composition of this glycan, as well as differences between the protein-bound glycan and that version of the glycan attached to the lipid upon which it is assembled.
34314490	1	60	theme	first	178:182	arg1	example					184:190	the first example	174:190	the first example of N-glycosylation outside the Eukarya	174:229	Although Halobacterium salinarum provided the first example of N-glycosylation outside the Eukarya, much regarding such post-translational modification in this halophilic archaea remains either unclear or unknown.
34314490	8	61	theme	protein-bound	1574:1586	arg1	stages					1588:1593	both the lipid- and protein-bound stages	1554:1593	stages	1588:1593	Knowing the composition of this glycan at both the lipid- and protein-bound stages, together with the availability of gene deletion approaches for manipulating Hbt.
34314490	7	62	theme	oligosaccharyltransferase	1379:1403	arg1	AglB					1405:1408	the oligosaccharyltransferase AglB	1375:1408	the oligosaccharyltransferase AglB	1375:1408	Moreover, in the absence of the oligosaccharyltransferase AglB, there is an accumulation of the dolichol phosphate-linked methylated and disulfated tetrasaccharide.
34314490	1	63	theme	halophilic	292:301	arg1	archaea					303:309	this halophilic archaea	287:309	this halophilic archaea	287:309	Although Halobacterium salinarum provided the first example of N-glycosylation outside the Eukarya, much regarding such post-translational modification in this halophilic archaea remains either unclear or unknown.
34314490	0	64	theme	dolichol	72:79	arg1	phosphate-					81:90	a dolichol phosphate-	70:90	a dolichol phosphate-	70:90	Revisiting N-glycosylation in Halobacterium salinarum: Characterizing a dolichol phosphate- and glycoprotein-bound tetrasaccharide.
34314490	5	65	theme	hexuronic	1178:1186	arg1	acid					1188:1191	a hexuronic acid	1176:1191	a hexuronic acid	1176:1191	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	5	65	theme	hexuronic	1178:1186	arg1	hexose					1141:1146	a hexose	1139:1146	a hexose	1139:1146	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	5	66	theme	N-linked	1074:1081	arg1	glycan					1083:1088	the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid	1070:1228	the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid	1070:1228	Such efforts revealed the N-linked glycan as corresponding to a tetrasaccharide comprising a hexose, a sulfated hexuronic acid, a hexuronic acid and a second sulfated hexuronic acid.
34314490	8	67	theme	deletion	1635:1642	arg1	approaches					1644:1653	gene deletion approaches	1630:1653	gene deletion approaches for manipulating Hbt	1630:1674	Knowing the composition of this glycan at both the lipid- and protein-bound stages, together with the availability of gene deletion approaches for manipulating Hbt.
34839971	9	0	theme	antioxidant	1134:1144	arg1	activity					1146:1153	good antioxidant activity	1129:1153	good antioxidant activity	1129:1153	The high susceptibility to biodegradation and good antioxidant activity confirms the potential application of examined systems in the packaging industry.
34839971	6	1	theme	structure	716:724	arg1	formation					726:734	the crystalline structure formation	700:734	the crystalline structure formation	700:734	Vitamin C addition prompts the crystalline structure formation and improves the hydrophilicity and antioxidant activity of the starch blends.
34839971	3	2	theme	X-ray	483:487	arg1	diffraction					489:499	X-ray diffraction	483:499	X-ray diffraction	483:499	The chemical structure was examined with ATR-FTIR spectroscopy and X-ray diffraction.
34839971	0	3	theme	dialdehyde	77:86	arg1	starch					88:93	dialdehyde starch	77:93	dialdehyde starch	77:93	Innovative and environmentally safe composites based on starch modified with dialdehyde starch, caffeine, or ascorbic acid for applications in the food packaging industry.
34839971	1	4	theme	food	324:327	arg1	industry					339:346	the food packaging industry	320:346	the food packaging industry	320:346	Biodegradable films based on starch modified with ascorbic acid or caffeine and dialdehyde starch (DS) were evaluated towards their applications in the food packaging industry.
34839971	1	5	from	applications	304:315	arg1	industry					339:346	the food packaging industry	320:346	the food packaging industry	320:346	Biodegradable films based on starch modified with ascorbic acid or caffeine and dialdehyde starch (DS) were evaluated towards their applications in the food packaging industry.
34839971	9	6	theme	packaging	1217:1225	arg1	industry					1227:1234	the packaging industry	1213:1234	the packaging industry	1213:1234	The high susceptibility to biodegradation and good antioxidant activity confirms the potential application of examined systems in the packaging industry.
34839971	4	7	theme	films	556:560	arg1	properties					538:547	The mechanical, thermal and barrier properties	502:547	The mechanical, thermal and barrier properties of the films	502:560	The mechanical, thermal and barrier properties of the films were examined.
34839971	1	8	theme	packaging	329:337	arg1	industry					339:346	the food packaging industry	320:346	the food packaging industry	320:346	Biodegradable films based on starch modified with ascorbic acid or caffeine and dialdehyde starch (DS) were evaluated towards their applications in the food packaging industry.
34839971	5	9	theme	cross-linking	581:593	arg1	effect					611:616	The cross-linking and hydrophobic effect	577:616	The cross-linking and hydrophobic effect of dialdehyde starch on starch-based films	577:659	The cross-linking and hydrophobic effect of dialdehyde starch on starch-based films was proven.
34839971	8	10	theme	acid	977:980	arg1	incorporation					982:994	ascorbic acid incorporation	968:994	ascorbic acid incorporation	968:994	Both caffeine and ascorbic acid incorporation influence the film stiffness, and dialdehyde starch causes an increase in brittleness.
34839971	1	11	theme	dialdehyde	252:261	arg1	starch					263:268	dialdehyde starch	252:268	dialdehyde starch	252:268	Biodegradable films based on starch modified with ascorbic acid or caffeine and dialdehyde starch (DS) were evaluated towards their applications in the food packaging industry.
34839971	8	12	from	increase	1058:1065	arg1	brittleness					1070:1080	brittleness	1070:1080	brittleness	1070:1080	Both caffeine and ascorbic acid incorporation influence the film stiffness, and dialdehyde starch causes an increase in brittleness.
34839971	6	13	theme	crystalline	704:714	arg1	formation					726:734	the crystalline structure formation	700:734	the crystalline structure formation	700:734	Vitamin C addition prompts the crystalline structure formation and improves the hydrophilicity and antioxidant activity of the starch blends.
34839971	5	14	theme	hydrophobic	599:609	arg1	effect					611:616	The cross-linking and hydrophobic effect	577:616	The cross-linking and hydrophobic effect of dialdehyde starch on starch-based films	577:659	The cross-linking and hydrophobic effect of dialdehyde starch on starch-based films was proven.
34839971	2	15	theme	surface	377:383	arg1	morphology					353:362	The morphology	349:362	The morphology of the films surface	349:383	The morphology of the films surface was observed with SEM and AFM.
34839971	6	16	theme	starch	800:805	arg1	blends					807:812	the starch blends	796:812	the starch blends	796:812	Vitamin C addition prompts the crystalline structure formation and improves the hydrophilicity and antioxidant activity of the starch blends.
34839971	7	17	theme	film	858:861	arg1	hydrophobicity					863:876	higher starch film hydrophobicity	844:876	higher starch film hydrophobicity	844:876	Caffeine addition results in higher starch film hydrophobicity, whereas caffeine combined with DS reduces crystalline order in starch.
34839971	2	18	theme	films	371:375	arg1	surface					377:383	the films surface	367:383	the films surface	367:383	The morphology of the films surface was observed with SEM and AFM.
34839971	5	19	theme	dialdehyde	621:630	arg1	starch					632:637	dialdehyde starch	621:637	dialdehyde starch	621:637	The cross-linking and hydrophobic effect of dialdehyde starch on starch-based films was proven.
34839971	1	20	theme	Biodegradable	172:184	arg1	films					186:190	Biodegradable films	172:190	Biodegradable films based on starch modified with ascorbic acid or caffeine and dialdehyde starch (DS)	172:273	Biodegradable films based on starch modified with ascorbic acid or caffeine and dialdehyde starch (DS) were evaluated towards their applications in the food packaging industry.
34839971	0	21	theme	Innovative	0:9	arg1	composites					36:45	Innovative and environmentally safe composites	0:45	Innovative and environmentally safe composites based on starch	0:61	Innovative and environmentally safe composites based on starch modified with dialdehyde starch, caffeine, or ascorbic acid for applications in the food packaging industry.
34839971	7	22	theme	Caffeine	815:822	arg1	addition					824:831	Caffeine addition	815:831	Caffeine addition	815:831	Caffeine addition results in higher starch film hydrophobicity, whereas caffeine combined with DS reduces crystalline order in starch.
34839971	5	23	theme	starch	632:637	arg1	effect					611:616	The cross-linking and hydrophobic effect	577:616	The cross-linking and hydrophobic effect of dialdehyde starch on starch-based films	577:659	The cross-linking and hydrophobic effect of dialdehyde starch on starch-based films was proven.
34839971	6	24	theme	C	681:681	arg1	addition					683:690	Vitamin C addition	673:690	Vitamin C addition	673:690	Vitamin C addition prompts the crystalline structure formation and improves the hydrophilicity and antioxidant activity of the starch blends.
34839971	5	25	theme	starch-based	642:653	arg1	films					655:659	starch-based films	642:659	starch-based films	642:659	The cross-linking and hydrophobic effect of dialdehyde starch on starch-based films was proven.
34839971	0	26	theme	safe	31:34	arg1	composites					36:45	Innovative and environmentally safe composites	0:45	Innovative and environmentally safe composites based on starch	0:61	Innovative and environmentally safe composites based on starch modified with dialdehyde starch, caffeine, or ascorbic acid for applications in the food packaging industry.
34839971	4	27	theme	barrier	530:536	arg1	properties					538:547	The mechanical, thermal and barrier properties	502:547	The mechanical, thermal and barrier properties of the films	502:560	The mechanical, thermal and barrier properties of the films were examined.
34839971	6	28	theme	blends	807:812	arg1	hydrophilicity					753:766	hydrophilicity	753:766	hydrophilicity	753:766	Vitamin C addition prompts the crystalline structure formation and improves the hydrophilicity and antioxidant activity of the starch blends.
34839971	6	28	theme	blends	807:812	arg1	activity					784:791	antioxidant activity	772:791	antioxidant activity	772:791	Vitamin C addition prompts the crystalline structure formation and improves the hydrophilicity and antioxidant activity of the starch blends.
34839971	6	29	theme	Vitamin	673:679	arg1	C					681:681	Vitamin C	673:681	Vitamin C addition	673:690	Vitamin C addition prompts the crystalline structure formation and improves the hydrophilicity and antioxidant activity of the starch blends.
34839971	9	30	from	application	1178:1188	arg1	industry					1227:1234	the packaging industry	1213:1234	the packaging industry	1213:1234	The high susceptibility to biodegradation and good antioxidant activity confirms the potential application of examined systems in the packaging industry.
34839971	5	31	from	effect	611:616	arg1	films					655:659	starch-based films	642:659	starch-based films	642:659	The cross-linking and hydrophobic effect of dialdehyde starch on starch-based films was proven.
34839971	0	32	theme	ascorbic	109:116	arg1	acid					118:121	ascorbic acid	109:121	ascorbic acid for applications in the food packaging industry	109:169	Innovative and environmentally safe composites based on starch modified with dialdehyde starch, caffeine, or ascorbic acid for applications in the food packaging industry.
34839971	0	33	from	starch	88:93	arg1	industry					162:169	the food packaging industry	143:169	the food packaging industry	143:169	Innovative and environmentally safe composites based on starch modified with dialdehyde starch, caffeine, or ascorbic acid for applications in the food packaging industry.
34839971	7	34	theme	higher	844:849	arg1	hydrophobicity					863:876	higher starch film hydrophobicity	844:876	higher starch film hydrophobicity	844:876	Caffeine addition results in higher starch film hydrophobicity, whereas caffeine combined with DS reduces crystalline order in starch.
34839971	3	35	theme	chemical	420:427	arg1	structure					429:437	The chemical structure	416:437	The chemical structure	416:437	The chemical structure was examined with ATR-FTIR spectroscopy and X-ray diffraction.
34839971	8	36	theme	dialdehyde	1030:1039	arg1	starch					1041:1046	dialdehyde starch	1030:1046	dialdehyde starch	1030:1046	Both caffeine and ascorbic acid incorporation influence the film stiffness, and dialdehyde starch causes an increase in brittleness.
34839971	6	37	theme	antioxidant	772:782	arg1	activity					784:791	antioxidant activity	772:791	antioxidant activity	772:791	Vitamin C addition prompts the crystalline structure formation and improves the hydrophilicity and antioxidant activity of the starch blends.
34839971	4	38	theme	mechanical	506:515	arg1	properties					538:547	The mechanical, thermal and barrier properties	502:547	The mechanical, thermal and barrier properties of the films	502:560	The mechanical, thermal and barrier properties of the films were examined.
34839971	7	39	theme	starch	851:856	arg1	hydrophobicity					863:876	higher starch film hydrophobicity	844:876	higher starch film hydrophobicity	844:876	Caffeine addition results in higher starch film hydrophobicity, whereas caffeine combined with DS reduces crystalline order in starch.
34839971	9	40	theme	potential	1168:1176	arg1	application					1178:1188	the potential application	1164:1188	the potential application of examined systems in the packaging industry	1164:1234	The high susceptibility to biodegradation and good antioxidant activity confirms the potential application of examined systems in the packaging industry.
34839971	9	41	theme	examined	1193:1200	arg1	systems					1202:1208	examined systems	1193:1208	examined systems	1193:1208	The high susceptibility to biodegradation and good antioxidant activity confirms the potential application of examined systems in the packaging industry.
34839971	4	42	theme	thermal	518:524	arg1	properties					538:547	The mechanical, thermal and barrier properties	502:547	The mechanical, thermal and barrier properties of the films	502:560	The mechanical, thermal and barrier properties of the films were examined.
34839971	0	43	theme	packaging	152:160	arg1	industry					162:169	the food packaging industry	143:169	the food packaging industry	143:169	Innovative and environmentally safe composites based on starch modified with dialdehyde starch, caffeine, or ascorbic acid for applications in the food packaging industry.
34839971	9	44	theme	good	1129:1132	arg1	activity					1146:1153	good antioxidant activity	1129:1153	good antioxidant activity	1129:1153	The high susceptibility to biodegradation and good antioxidant activity confirms the potential application of examined systems in the packaging industry.
34839971	8	45	theme	film	1010:1013	arg1	stiffness					1015:1023	the film stiffness	1006:1023	the film stiffness	1006:1023	Both caffeine and ascorbic acid incorporation influence the film stiffness, and dialdehyde starch causes an increase in brittleness.
34839971	0	46	theme	food	147:150	arg1	industry					162:169	the food packaging industry	143:169	the food packaging industry	143:169	Innovative and environmentally safe composites based on starch modified with dialdehyde starch, caffeine, or ascorbic acid for applications in the food packaging industry.
34839971	0	47	from	caffeine	96:103	arg1	industry					162:169	the food packaging industry	143:169	the food packaging industry	143:169	Innovative and environmentally safe composites based on starch modified with dialdehyde starch, caffeine, or ascorbic acid for applications in the food packaging industry.
34839971	8	48	theme	ascorbic	968:975	arg1	incorporation					982:994	ascorbic acid incorporation	968:994	ascorbic acid incorporation	968:994	Both caffeine and ascorbic acid incorporation influence the film stiffness, and dialdehyde starch causes an increase in brittleness.
34839971	3	49	theme	ATR-FTIR	457:464	arg1	spectroscopy					466:477	ATR-FTIR spectroscopy	457:477	ATR-FTIR spectroscopy	457:477	The chemical structure was examined with ATR-FTIR spectroscopy and X-ray diffraction.
34839971	1	50	theme	ascorbic	222:229	arg1	acid					231:234	ascorbic acid	222:234	ascorbic acid	222:234	Biodegradable films based on starch modified with ascorbic acid or caffeine and dialdehyde starch (DS) were evaluated towards their applications in the food packaging industry.
34839971	9	51	theme	high	1087:1090	arg1	susceptibility					1092:1105	The high susceptibility	1083:1105	The high susceptibility to biodegradation and good antioxidant activity	1083:1153	The high susceptibility to biodegradation and good antioxidant activity confirms the potential application of examined systems in the packaging industry.
34839971	9	52	theme	systems	1202:1208	arg1	application					1178:1188	the potential application	1164:1188	the potential application of examined systems in the packaging industry	1164:1234	The high susceptibility to biodegradation and good antioxidant activity confirms the potential application of examined systems in the packaging industry.
34839971	7	53	theme	crystalline	921:931	arg1	order					933:937	crystalline order	921:937	crystalline order	921:937	Caffeine addition results in higher starch film hydrophobicity, whereas caffeine combined with DS reduces crystalline order in starch.
34839971	0	54	from	acid	118:121	arg1	industry					162:169	the food packaging industry	143:169	the food packaging industry	143:169	Innovative and environmentally safe composites based on starch modified with dialdehyde starch, caffeine, or ascorbic acid for applications in the food packaging industry.
34839971	6	55	dep	hydrophilicity	753:766	arg1	the					749:751	the	749:751	the	749:751	Vitamin C addition prompts the crystalline structure formation and improves the hydrophilicity and antioxidant activity of the starch blends.
33213137	5	0	theme	expressed	838:846	arg1	deacetylase					848:858	a recombinantly expressed deacetylase	822:858	a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9)	822:890	The building blocks were generated from readily available (GlcNAc)2-para-nitrophenol through deacetylation of the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9).
33213137	6	1	contain	containing	1141:1150	arg1	CHOS					1136:1139	CHOS	1136:1139	CHOS containing up to ten alternating D	1136:1174	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	1	contain	containing	1141:1150	arg2	D					1174:1174	up to ten alternating D	1152:1174	up to ten alternating D	1152:1174	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	2	theme	alternating	1162:1172	arg1	D					1174:1174	up to ten alternating D	1152:1174	up to ten alternating D	1152:1174	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	4	3	theme	DA	624:625	arg1	blocks					636:641	activated DA building blocks	614:641	activated DA building blocks	614:641	We have used engineered glycoside hydrolases to catalyze oligomerization of activated DA building blocks through transglycosylation reactions.
33213137	6	4	from	proteamaculans	1090:1103	arg1	SmChiA					1004:1009	SmChiA	1004:1009	SmChiA	1004:1009	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	4	from	proteamaculans	1090:1103	arg1	variant					1053:1059	a newly generated transglycosylating variant	1016:1059	a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD)	1016:1112	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	4	from	proteamaculans	1090:1103	arg1	SpChiD					1106:1111	SpChiD	1106:1111	SpChiD	1106:1111	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	4	from	proteamaculans	1090:1103	arg1	variant					962:968	a previously described hyper-transglycosylating variant	914:968	a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA)	914:1010	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	2	5	theme	great	346:350	arg1	interest					352:359	great interest	346:359	great interest	346:359	Production of well-defined CHOS-mixtures, or even pure CHOS, with specific lengths and sugar compositions, is of great interest since these oligosaccharides have interesting bioactivities.
33213137	4	6	theme	activated	614:622	arg1	blocks					636:641	activated DA building blocks	614:641	activated DA building blocks	614:641	We have used engineered glycoside hydrolases to catalyze oligomerization of activated DA building blocks through transglycosylation reactions.
33213137	5	7	theme	nonreducing	795:805	arg1	sugar					811:815	the nonreducing end sugar	791:815	the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9)	791:890	The building blocks were generated from readily available (GlcNAc)2-para-nitrophenol through deacetylation of the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9).
33213137	9	8	theme	systemic	1485:1492	arg1	sclerosis					1494:1502	systemic sclerosis	1485:1502	systemic sclerosis	1485:1502	Inhibition of this enzyme has been suggested as a therapeutic strategy against systemic sclerosis.
33213137	4	9	theme	blocks	636:641	arg1	oligomerization					595:609	oligomerization	595:609	oligomerization of activated DA building blocks	595:641	We have used engineered glycoside hydrolases to catalyze oligomerization of activated DA building blocks through transglycosylation reactions.
33213137	5	10	theme	end	807:809	arg1	sugar					811:815	the nonreducing end sugar	791:815	the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9)	791:890	The building blocks were generated from readily available (GlcNAc)2-para-nitrophenol through deacetylation of the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9).
33213137	5	11	theme	available	729:737	arg1	2-para-nitrophenol					747:764	readily available (GlcNAc)2-para-nitrophenol	721:764	readily available (GlcNAc)2-para-nitrophenol	721:764	The building blocks were generated from readily available (GlcNAc)2-para-nitrophenol through deacetylation of the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9).
33213137	1	12	dep	N-acetylglucosamine	172:190	arg1	GlcNAc					193:198	GlcNAc	193:198	GlcNAc	193:198	Chito-oligosaccharides (CHOS) are homo- or hetero-oligomers of N-acetylglucosamine (GlcNAc, A) and d-glucosamine (GlcN, D).
33213137	1	12	dep	N-acetylglucosamine	172:190	arg1	A					201:201	A	201:201	A	201:201	Chito-oligosaccharides (CHOS) are homo- or hetero-oligomers of N-acetylglucosamine (GlcNAc, A) and d-glucosamine (GlcN, D).
33213137	4	13	theme	building	627:634	arg1	blocks					636:641	activated DA building blocks	614:641	activated DA building blocks	614:641	We have used engineered glycoside hydrolases to catalyze oligomerization of activated DA building blocks through transglycosylation reactions.
33213137	5	14	theme	sugar	811:815	arg1	deacetylation					774:786	deacetylation	774:786	deacetylation of the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9)	774:890	The building blocks were generated from readily available (GlcNAc)2-para-nitrophenol through deacetylation of the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9).
33213137	2	15	theme	CHOS	288:291	arg1	Production					233:242	Production	233:242	Production	233:242	Production of well-defined CHOS-mixtures, or even pure CHOS, with specific lengths and sugar compositions, is of great interest since these oligosaccharides have interesting bioactivities.
33213137	3	16	theme	CHOS	457:460	arg1	synthesis					444:452	direct chemical synthesis	428:452	direct chemical synthesis of CHOS	428:460	While direct chemical synthesis of CHOS is not straightforward, chemo-enzymatic approaches have shown some promise.
33213137	6	17	theme	D	1074:1074	arg1	SmChiA					1004:1009	SmChiA	1004:1009	SmChiA	1004:1009	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	17	theme	D	1074:1074	arg1	variant					1053:1059	a newly generated transglycosylating variant	1016:1059	a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD)	1016:1112	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	17	theme	D	1074:1074	arg1	SpChiD					1106:1111	SpChiD	1106:1111	SpChiD	1106:1111	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	17	theme	D	1074:1074	arg1	variant					962:968	a previously described hyper-transglycosylating variant	914:968	a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA)	914:1010	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	18	theme	ChiA	973:976	arg1	SmChiA					1004:1009	SmChiA	1004:1009	SmChiA	1004:1009	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	18	theme	ChiA	973:976	arg1	variant					1053:1059	a newly generated transglycosylating variant	1016:1059	a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD)	1016:1112	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	18	theme	ChiA	973:976	arg1	SpChiD					1106:1111	SpChiD	1106:1111	SpChiD	1106:1111	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	18	theme	ChiA	973:976	arg1	variant					962:968	a previously described hyper-transglycosylating variant	914:968	a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA)	914:1010	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	5	19	theme	building	685:692	arg1	blocks					694:699	The building blocks	681:699	The building blocks	681:699	The building blocks were generated from readily available (GlcNAc)2-para-nitrophenol through deacetylation of the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9).
33213137	2	20	theme	pure	283:286	arg1	CHOS					288:291	pure CHOS	283:291	pure CHOS	283:291	Production of well-defined CHOS-mixtures, or even pure CHOS, with specific lengths and sugar compositions, is of great interest since these oligosaccharides have interesting bioactivities.
33213137	2	21	theme	interesting	395:405	arg1	bioactivities					407:419	interesting bioactivities	395:419	interesting bioactivities	395:419	Production of well-defined CHOS-mixtures, or even pure CHOS, with specific lengths and sugar compositions, is of great interest since these oligosaccharides have interesting bioactivities.
33213137	4	22	used	used	546:549	arg2	We					538:539	We	538:539	We	538:539	We have used engineered glycoside hydrolases to catalyze oligomerization of activated DA building blocks through transglycosylation reactions.
33213137	6	23	theme	Chitinase	1064:1072	arg1	D					1074:1074	Chitinase D	1064:1074	Chitinase D	1064:1074	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	2	24	theme	sugar	320:324	arg1	compositions					326:337	sugar compositions	320:337	sugar compositions	320:337	Production of well-defined CHOS-mixtures, or even pure CHOS, with specific lengths and sugar compositions, is of great interest since these oligosaccharides have interesting bioactivities.
33213137	1	25	theme	d-glucosamine	208:220	arg1	hetero-oligomers					152:167	hetero-oligomers	152:167	hetero-oligomers of N-acetylglucosamine (GlcNAc, A) and d-glucosamine (GlcN, D)	152:230	Chito-oligosaccharides (CHOS) are homo- or hetero-oligomers of N-acetylglucosamine (GlcNAc, A) and d-glucosamine (GlcN, D).
33213137	0	26	theme	Chemoenzymatic	0:13	arg1	Synthesis					15:23	Chemoenzymatic Synthesis	0:23	Chemoenzymatic Synthesis of	0:26	Chemoenzymatic Synthesis of Chito-oligosaccharides with Alternating N-d-Acetylglucosamine and d-Glucosamine.
33213137	2	27	with	Production	233:242	arg1	lengths					308:314	specific lengths	299:314	specific lengths	299:314	Production of well-defined CHOS-mixtures, or even pure CHOS, with specific lengths and sugar compositions, is of great interest since these oligosaccharides have interesting bioactivities.
33213137	2	27	with	Production	233:242	arg1	compositions					326:337	sugar compositions	320:337	sugar compositions	320:337	Production of well-defined CHOS-mixtures, or even pure CHOS, with specific lengths and sugar compositions, is of great interest since these oligosaccharides have interesting bioactivities.
33213137	6	28	gly	transglycosylating	1034:1051	arg0	SpChiD					1106:1111	SpChiD	1106:1111	SpChiD	1106:1111	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	28	gly	transglycosylating	1034:1051	arg0	variant					1053:1059	a newly generated transglycosylating variant	1016:1059	a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD)	1016:1112	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	29	gly	hyper-transglycosylating	937:960	arg0	SmChiA					1004:1009	SmChiA	1004:1009	SmChiA	1004:1009	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	29	gly	hyper-transglycosylating	937:960	arg0	variant					962:968	a previously described hyper-transglycosylating variant	914:968	a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA)	914:1010	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	30	theme	CHOS	1136:1139	arg1	DA					1204:1205	(DA)4	1203:1207	(DA)4	1203:1207	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	30	theme	CHOS	1136:1139	arg1	units					1182:1186	A units	1180:1186	A units [(DA)2, (DA)3, (DA)4, and (DA)5]	1180:1219	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	30	theme	CHOS	1136:1139	arg1	DA					1215:1216	(DA)5	1214:1218	(DA)5	1214:1218	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	30	theme	CHOS	1136:1139	arg1	production					1122:1131	production	1122:1131	production of CHOS containing up to ten alternating D	1122:1174	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	30	theme	CHOS	1136:1139	arg1	DA					1197:1198	(DA)3	1196:1200	(DA)3	1196:1200	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	30	theme	CHOS	1136:1139	arg1	DA					1190:1191	(DA)2	1189:1193	(DA)2	1189:1193	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	31	from	variant	962:968	arg1	marcescens					992:1001	Serratia marcescens	983:1001	Serratia marcescens	983:1001	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	32	from	variant	1053:1059	arg1	marcescens					992:1001	Serratia marcescens	983:1001	Serratia marcescens	983:1001	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	2	33	theme	well-defined	247:258	arg1	CHOS-mixtures					260:272	well-defined CHOS-mixtures	247:272	well-defined CHOS-mixtures	247:272	Production of well-defined CHOS-mixtures, or even pure CHOS, with specific lengths and sugar compositions, is of great interest since these oligosaccharides have interesting bioactivities.
33213137	8	34	theme	human	1383:1387	arg1	chitotriosidase					1389:1403	the human chitotriosidase	1379:1403	the human chitotriosidase	1379:1403	Finally, we demonstrate that (DA)3 generated in this study may serve as a specific inhibitor of the human chitotriosidase.
33213137	2	35	theme	specific	299:306	arg1	lengths					308:314	specific lengths	299:314	specific lengths	299:314	Production of well-defined CHOS-mixtures, or even pure CHOS, with specific lengths and sugar compositions, is of great interest since these oligosaccharides have interesting bioactivities.
33213137	9	36	theme	therapeutic	1456:1466	arg1	strategy					1468:1475	a therapeutic strategy	1454:1475	a therapeutic strategy against systemic sclerosis	1454:1502	Inhibition of this enzyme has been suggested as a therapeutic strategy against systemic sclerosis.
33213137	9	36	theme	therapeutic	1456:1466	arg1	Inhibition					1406:1415	Inhibition	1406:1415	Inhibition of this enzyme	1406:1430	Inhibition of this enzyme has been suggested as a therapeutic strategy against systemic sclerosis.
33213137	3	37	theme	chemo-enzymatic	486:500	arg1	approaches					502:511	chemo-enzymatic approaches	486:511	chemo-enzymatic approaches	486:511	While direct chemical synthesis of CHOS is not straightforward, chemo-enzymatic approaches have shown some promise.
33213137	3	38	theme	direct	428:433	arg1	synthesis					444:452	direct chemical synthesis	428:452	direct chemical synthesis of CHOS	428:460	While direct chemical synthesis of CHOS is not straightforward, chemo-enzymatic approaches have shown some promise.
33213137	6	39	theme	transglycosylating	1034:1051	arg1	variant					1053:1059	a newly generated transglycosylating variant	1016:1059	a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD)	1016:1112	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	39	theme	transglycosylating	1034:1051	arg1	SpChiD					1106:1111	SpChiD	1106:1111	SpChiD	1106:1111	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	2	40	contain	have	390:393	arg1	oligosaccharides					373:388	these oligosaccharides	367:388	these oligosaccharides	367:388	Production of well-defined CHOS-mixtures, or even pure CHOS, with specific lengths and sugar compositions, is of great interest since these oligosaccharides have interesting bioactivities.
33213137	2	40	contain	have	390:393	arg2	bioactivities					407:419	interesting bioactivities	395:419	interesting bioactivities	395:419	Production of well-defined CHOS-mixtures, or even pure CHOS, with specific lengths and sugar compositions, is of great interest since these oligosaccharides have interesting bioactivities.
33213137	1	41	dep	d-glucosamine	208:220	arg1	D					229:229	D	229:229	D	229:229	Chito-oligosaccharides (CHOS) are homo- or hetero-oligomers of N-acetylglucosamine (GlcNAc, A) and d-glucosamine (GlcN, D).
33213137	1	41	dep	d-glucosamine	208:220	arg1	GlcN					223:226	GlcN	223:226	GlcN	223:226	Chito-oligosaccharides (CHOS) are homo- or hetero-oligomers of N-acetylglucosamine (GlcNAc, A) and d-glucosamine (GlcN, D).
33213137	3	42	theme	chemical	435:442	arg1	synthesis					444:452	direct chemical synthesis	428:452	direct chemical synthesis of CHOS	428:460	While direct chemical synthesis of CHOS is not straightforward, chemo-enzymatic approaches have shown some promise.
33213137	4	43	theme	engineered	551:560	arg1	hydrolases					572:581	engineered glycoside hydrolases	551:581	engineered glycoside hydrolases	551:581	We have used engineered glycoside hydrolases to catalyze oligomerization of activated DA building blocks through transglycosylation reactions.
33213137	5	44	theme	Aspergillus	865:875	arg1	niger					877:881	Aspergillus niger	865:881	Aspergillus niger (AnCDA9)	865:890	The building blocks were generated from readily available (GlcNAc)2-para-nitrophenol through deacetylation of the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9).
33213137	5	44	theme	Aspergillus	865:875	arg1	AnCDA9					884:889	AnCDA9	884:889	AnCDA9	884:889	The building blocks were generated from readily available (GlcNAc)2-para-nitrophenol through deacetylation of the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9).
33213137	6	45	theme	Serratia	1081:1088	arg1	proteamaculans					1090:1103	Serratia proteamaculans	1081:1103	Serratia proteamaculans	1081:1103	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	5	46	dep	available	729:737	arg1	GlcNAc					740:745	GlcNAc	740:745	GlcNAc	740:745	The building blocks were generated from readily available (GlcNAc)2-para-nitrophenol through deacetylation of the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9).
33213137	5	47	with	sugar	811:815	arg1	deacetylase					848:858	a recombinantly expressed deacetylase	822:858	a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9)	822:890	The building blocks were generated from readily available (GlcNAc)2-para-nitrophenol through deacetylation of the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9).
33213137	6	48	theme	generated	1024:1032	arg1	variant					1053:1059	a newly generated transglycosylating variant	1016:1059	a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD)	1016:1112	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	48	theme	generated	1024:1032	arg1	SpChiD					1106:1111	SpChiD	1106:1111	SpChiD	1106:1111	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	49	theme	described	927:935	arg1	SmChiA					1004:1009	SmChiA	1004:1009	SmChiA	1004:1009	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	49	theme	described	927:935	arg1	variant					962:968	a previously described hyper-transglycosylating variant	914:968	a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA)	914:1010	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	4	50	theme	glycoside	562:570	arg1	hydrolases					572:581	engineered glycoside hydrolases	551:581	engineered glycoside hydrolases	551:581	We have used engineered glycoside hydrolases to catalyze oligomerization of activated DA building blocks through transglycosylation reactions.
33213137	8	51	theme	chitotriosidase	1389:1403	arg1	inhibitor					1366:1374	a specific inhibitor	1355:1374	a specific inhibitor of the human chitotriosidase	1355:1403	Finally, we demonstrate that (DA)3 generated in this study may serve as a specific inhibitor of the human chitotriosidase.
33213137	8	51	theme	chitotriosidase	1389:1403	arg1	DA					1313:1314	(DA)3	1312:1316	(DA)3 generated in this study	1312:1340	Finally, we demonstrate that (DA)3 generated in this study may serve as a specific inhibitor of the human chitotriosidase.
33213137	6	52	dep	units	1182:1186	arg1	DA					1204:1205	(DA)4	1203:1207	(DA)4	1203:1207	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	52	dep	units	1182:1186	arg1	DA					1197:1198	(DA)3	1196:1200	(DA)3	1196:1200	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	52	dep	units	1182:1186	arg1	DA					1190:1191	(DA)2	1189:1193	(DA)2	1189:1193	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	52	dep	units	1182:1186	arg1	DA					1215:1216	(DA)5	1214:1218	(DA)5	1214:1218	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	52	dep	units	1182:1186	arg1	units					1182:1186	A units	1180:1186	A units [(DA)2, (DA)3, (DA)4, and (DA)5]	1180:1219	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	53	dep	ten	1158:1160	arg1	to					1155:1156	to	1155:1156	to	1155:1156	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	4	54	theme	transglycosylation	651:668	arg1	reactions					670:678	transglycosylation reactions	651:678	transglycosylation reactions	651:678	We have used engineered glycoside hydrolases to catalyze oligomerization of activated DA building blocks through transglycosylation reactions.
33213137	7	55	theme	abundant	1231:1238	arg1	compounds					1240:1248	The most abundant compounds	1222:1248	The most abundant compounds	1222:1248	The most abundant compounds were purified and characterized.
33213137	1	56	theme	N-acetylglucosamine	172:190	arg1	hetero-oligomers					152:167	hetero-oligomers	152:167	hetero-oligomers of N-acetylglucosamine (GlcNAc, A) and d-glucosamine (GlcN, D)	152:230	Chito-oligosaccharides (CHOS) are homo- or hetero-oligomers of N-acetylglucosamine (GlcNAc, A) and d-glucosamine (GlcN, D).
33213137	6	57	theme	hyper-transglycosylating	937:960	arg1	SmChiA					1004:1009	SmChiA	1004:1009	SmChiA	1004:1009	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	57	theme	hyper-transglycosylating	937:960	arg1	variant					962:968	a previously described hyper-transglycosylating variant	914:968	a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA)	914:1010	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	8	58	theme	specific	1357:1364	arg1	inhibitor					1366:1374	a specific inhibitor	1355:1374	a specific inhibitor of the human chitotriosidase	1355:1403	Finally, we demonstrate that (DA)3 generated in this study may serve as a specific inhibitor of the human chitotriosidase.
33213137	8	58	theme	specific	1357:1364	arg1	DA					1313:1314	(DA)3	1312:1316	(DA)3 generated in this study	1312:1340	Finally, we demonstrate that (DA)3 generated in this study may serve as a specific inhibitor of the human chitotriosidase.
33213137	9	59	theme	enzyme	1425:1430	arg1	strategy					1468:1475	a therapeutic strategy	1454:1475	a therapeutic strategy against systemic sclerosis	1454:1502	Inhibition of this enzyme has been suggested as a therapeutic strategy against systemic sclerosis.
33213137	9	59	theme	enzyme	1425:1430	arg1	Inhibition					1406:1415	Inhibition	1406:1415	Inhibition of this enzyme	1406:1430	Inhibition of this enzyme has been suggested as a therapeutic strategy against systemic sclerosis.
33213137	6	60	from	marcescens	992:1001	arg1	SmChiA					1004:1009	SmChiA	1004:1009	SmChiA	1004:1009	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	60	from	marcescens	992:1001	arg1	variant					1053:1059	a newly generated transglycosylating variant	1016:1059	a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD)	1016:1112	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	60	from	marcescens	992:1001	arg1	SpChiD					1106:1111	SpChiD	1106:1111	SpChiD	1106:1111	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	60	from	marcescens	992:1001	arg1	ChiA					973:976	ChiA	973:976	ChiA from Serratia marcescens	973:1001	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	6	60	from	marcescens	992:1001	arg1	variant					962:968	a previously described hyper-transglycosylating variant	914:968	a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA)	914:1010	This approach, using a previously described hyper-transglycosylating variant of ChiA from Serratia marcescens (SmChiA) and a newly generated transglycosylating variant of Chitinase D from Serratia proteamaculans (SpChiD), led to production of CHOS containing up to ten alternating D and A units [(DA)2, (DA)3, (DA)4, and (DA)5].
33213137	5	61	from	niger	877:881	arg1	deacetylase					848:858	a recombinantly expressed deacetylase	822:858	a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9)	822:890	The building blocks were generated from readily available (GlcNAc)2-para-nitrophenol through deacetylation of the nonreducing end sugar with a recombinantly expressed deacetylase from Aspergillus niger (AnCDA9).
33213137	2	62	theme	CHOS-mixtures	260:272	arg1	Production					233:242	Production	233:242	Production	233:242	Production of well-defined CHOS-mixtures, or even pure CHOS, with specific lengths and sugar compositions, is of great interest since these oligosaccharides have interesting bioactivities.
34508720	7	0	theme	CMS/PVA	1051:1057	arg1	blend					1059:1063	the CMS/PVA blend	1047:1063	the CMS/PVA blend	1047:1063	This is the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend.
34508720	2	1	with	starch	260:265	arg1	DS					278:279	DS 0.31	278:284	DS 0.31	278:284	The water-soluble sodium carboxymethyl starch (CMS) with DS 0.31 was prepared.
34508720	8	2	theme	nano-scale	1127:1136	arg1	fibers					1138:1143	starch-based nano-scale fibers	1114:1143	starch-based nano-scale fibers	1114:1143	This study provided a green approach to produce starch-based nano-scale fibers.
34508720	8	3	theme	green	1088:1092	arg1	approach					1094:1101	a green approach	1086:1101	a green approach to produce starch-based nano-scale fibers	1086:1143	This study provided a green approach to produce starch-based nano-scale fibers.
34508720	4	4	theme	nanofibers	617:626	arg1	morphologies					601:612	the morphologies	597:612	the morphologies of nanofibers	597:626	The solution parameters including viscosity, surface tension and conductivity were measured and the morphologies of nanofibers were observed by SEM.
34508720	3	5	from	solution	442:449	arg1	blends					422:427	blends	422:427	blends from aqueous solution	422:449	The addition of co-blending polymer polyvinyl-alcohol (PVA) was attempted to improve the CMS solution spinnability, which blends from aqueous solution were prepared at different CMS/PVA weight ratios.
34508720	6	6	theme	nanofibers	855:864	arg1	diameter					839:846	the diameter	835:846	the diameter of the nanofibers	835:864	Diameter distribution diagrams suggested that the diameter of the nanofibers reduced with the concentration of CMS increasing.
34508720	7	7	theme	maximal	1012:1018	arg1	content					1024:1030	the maximal CMS content	1008:1030	the maximal CMS content of 50.0 wt% in the CMS/PVA blend	1008:1063	This is the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend.
34508720	3	8	theme	CMS	389:391	arg1	spinnability					402:413	the CMS solution spinnability	385:413	the CMS solution spinnability	385:413	The addition of co-blending polymer polyvinyl-alcohol (PVA) was attempted to improve the CMS solution spinnability, which blends from aqueous solution were prepared at different CMS/PVA weight ratios.
34508720	4	9	theme	solution	505:512	arg1	parameters					514:523	The solution parameters	501:523	The solution parameters including viscosity, surface tension and conductivity	501:577	The solution parameters including viscosity, surface tension and conductivity were measured and the morphologies of nanofibers were observed by SEM.
34508720	4	9	theme	solution	505:512	arg1	conductivity					566:577	conductivity	566:577	conductivity	566:577	The solution parameters including viscosity, surface tension and conductivity were measured and the morphologies of nanofibers were observed by SEM.
34508720	4	9	theme	solution	505:512	arg1	viscosity					535:543	viscosity	535:543	viscosity	535:543	The solution parameters including viscosity, surface tension and conductivity were measured and the morphologies of nanofibers were observed by SEM.
34508720	4	9	theme	solution	505:512	arg1	tension					554:560	surface tension	546:560	surface tension	546:560	The solution parameters including viscosity, surface tension and conductivity were measured and the morphologies of nanofibers were observed by SEM.
34508720	5	10	theme	Smooth	650:655	arg1	nanofibers					686:695	Smooth, continuous, and defect-free nanofibers	650:695	Smooth, continuous, and defect-free nanofibers	650:695	Smooth, continuous, and defect-free nanofibers were successfully obtained range from the blend of CMS/PVA weight ratios of 10:90 to 80:20.
34508720	5	11	theme	continuous	658:667	arg1	nanofibers					686:695	Smooth, continuous, and defect-free nanofibers	650:695	Smooth, continuous, and defect-free nanofibers	650:695	Smooth, continuous, and defect-free nanofibers were successfully obtained range from the blend of CMS/PVA weight ratios of 10:90 to 80:20.
34508720	5	12	theme	80:20	782:786	arg1	ratios					763:768	CMS/PVA weight ratios	748:768	CMS/PVA weight ratios of 10:90 to 80:20	748:786	Smooth, continuous, and defect-free nanofibers were successfully obtained range from the blend of CMS/PVA weight ratios of 10:90 to 80:20.
34508720	0	13	theme	composite	66:74	arg1	Preparation					0:10	Preparation	0:10	Preparation of carboxymethyl starch/polyvinyl-alcohol electrospun composite	0:74	Preparation of carboxymethyl starch/polyvinyl-alcohol electrospun composite nanofibers from a green approach.
34508720	3	14	theme	different	468:476	arg1	ratios					493:498	different CMS/PVA weight ratios	468:498	different CMS/PVA weight ratios	468:498	The addition of co-blending polymer polyvinyl-alcohol (PVA) was attempted to improve the CMS solution spinnability, which blends from aqueous solution were prepared at different CMS/PVA weight ratios.
34508720	7	15	with	nanofiber	955:963	arg1	bead-free					982:990	bead-free	982:990	bead-free	982:990	This is the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend.
34508720	8	16	theme	starch-based	1114:1125	arg1	fibers					1138:1143	starch-based nano-scale fibers	1114:1143	starch-based nano-scale fibers	1114:1143	This study provided a green approach to produce starch-based nano-scale fibers.
34508720	5	17	theme	defect-free	674:684	arg1	nanofibers					686:695	Smooth, continuous, and defect-free nanofibers	650:695	Smooth, continuous, and defect-free nanofibers	650:695	Smooth, continuous, and defect-free nanofibers were successfully obtained range from the blend of CMS/PVA weight ratios of 10:90 to 80:20.
34508720	1	18	theme	green	112:116	arg1	approach					118:125	A green approach	110:125	A green approach for the preparation of starch-based composite nanofibers using electrospinning	110:204	A green approach for the preparation of starch-based composite nanofibers using electrospinning was developed.
34508720	7	19	from	content	1024:1030	arg1	blend					1059:1063	the CMS/PVA blend	1047:1063	the CMS/PVA blend	1047:1063	This is the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend.
34508720	3	20	theme	solution	393:400	arg1	spinnability					402:413	the CMS solution spinnability	385:413	the CMS solution spinnability	385:413	The addition of co-blending polymer polyvinyl-alcohol (PVA) was attempted to improve the CMS solution spinnability, which blends from aqueous solution were prepared at different CMS/PVA weight ratios.
34508720	7	21	dep	report	934:939	arg1	obtained					996:1003	obtained	996:1003	was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend	992:1063	This is the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend.
34508720	0	22	theme	carboxymethyl	15:27	arg1	composite					66:74	carboxymethyl starch/polyvinyl-alcohol electrospun composite	15:74	carboxymethyl starch/polyvinyl-alcohol electrospun composite	15:74	Preparation of carboxymethyl starch/polyvinyl-alcohol electrospun composite nanofibers from a green approach.
34508720	5	23	theme	CMS/PVA	748:754	arg1	ratios					763:768	CMS/PVA weight ratios	748:768	CMS/PVA weight ratios of 10:90 to 80:20	748:786	Smooth, continuous, and defect-free nanofibers were successfully obtained range from the blend of CMS/PVA weight ratios of 10:90 to 80:20.
34508720	3	24	theme	aqueous	434:440	arg1	solution					442:449	aqueous solution	434:449	aqueous solution	434:449	The addition of co-blending polymer polyvinyl-alcohol (PVA) was attempted to improve the CMS solution spinnability, which blends from aqueous solution were prepared at different CMS/PVA weight ratios.
34508720	5	25	theme	weight	756:761	arg1	ratios					763:768	CMS/PVA weight ratios	748:768	CMS/PVA weight ratios of 10:90 to 80:20	748:786	Smooth, continuous, and defect-free nanofibers were successfully obtained range from the blend of CMS/PVA weight ratios of 10:90 to 80:20.
34508720	7	26	from	%	1042:1042	arg1	blend					1059:1063	the CMS/PVA blend	1047:1063	the CMS/PVA blend	1047:1063	This is the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend.
34508720	3	27	theme	CMS/PVA	478:484	arg1	ratios					493:498	different CMS/PVA weight ratios	468:498	different CMS/PVA weight ratios	468:498	The addition of co-blending polymer polyvinyl-alcohol (PVA) was attempted to improve the CMS solution spinnability, which blends from aqueous solution were prepared at different CMS/PVA weight ratios.
34508720	0	28	theme	electrospun	54:64	arg1	composite					66:74	carboxymethyl starch/polyvinyl-alcohol electrospun composite	15:74	carboxymethyl starch/polyvinyl-alcohol electrospun composite	15:74	Preparation of carboxymethyl starch/polyvinyl-alcohol electrospun composite nanofibers from a green approach.
34508720	5	29	theme	ratios	763:768	arg1	blend					739:743	the blend	735:743	the blend of CMS/PVA weight ratios of 10:90 to 80:20	735:786	Smooth, continuous, and defect-free nanofibers were successfully obtained range from the blend of CMS/PVA weight ratios of 10:90 to 80:20.
34508720	6	30	theme	increasing	904:913	arg1	CMS					900:902	CMS increasing	900:913	CMS increasing	900:913	Diameter distribution diagrams suggested that the diameter of the nanofibers reduced with the concentration of CMS increasing.
34508720	0	31	theme	starch/polyvinyl-alcohol	29:52	arg1	composite					66:74	carboxymethyl starch/polyvinyl-alcohol electrospun composite	15:74	carboxymethyl starch/polyvinyl-alcohol electrospun composite	15:74	Preparation of carboxymethyl starch/polyvinyl-alcohol electrospun composite nanofibers from a green approach.
34508720	7	32	theme	%	1042:1042	arg1	content					1024:1030	the maximal CMS content	1008:1030	the maximal CMS content of 50.0 wt% in the CMS/PVA blend	1008:1063	This is the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend.
34508720	3	33	theme	weight	486:491	arg1	ratios					493:498	different CMS/PVA weight ratios	468:498	different CMS/PVA weight ratios	468:498	The addition of co-blending polymer polyvinyl-alcohol (PVA) was attempted to improve the CMS solution spinnability, which blends from aqueous solution were prepared at different CMS/PVA weight ratios.
34508720	3	34	theme	polyvinyl-alcohol	336:352	arg1	addition					304:311	The addition	300:311	The addition of co-blending polymer polyvinyl-alcohol (PVA)	300:358	The addition of co-blending polymer polyvinyl-alcohol (PVA) was attempted to improve the CMS solution spinnability, which blends from aqueous solution were prepared at different CMS/PVA weight ratios.
34508720	6	35	theme	CMS	900:902	arg1	concentration					883:895	the concentration	879:895	the concentration of CMS increasing	879:913	Diameter distribution diagrams suggested that the diameter of the nanofibers reduced with the concentration of CMS increasing.
34508720	6	36	theme	distribution	798:809	arg1	diagrams					811:818	Diameter distribution diagrams	789:818	Diameter distribution diagrams	789:818	Diameter distribution diagrams suggested that the diameter of the nanofibers reduced with the concentration of CMS increasing.
34508720	4	37	theme	surface	546:552	arg1	tension					554:560	surface tension	546:560	surface tension	546:560	The solution parameters including viscosity, surface tension and conductivity were measured and the morphologies of nanofibers were observed by SEM.
34508720	5	38	dep	80:20	782:786	arg1	to					779:780	to	779:780	to	779:780	Smooth, continuous, and defect-free nanofibers were successfully obtained range from the blend of CMS/PVA weight ratios of 10:90 to 80:20.
34508720	6	39	theme	Diameter	789:796	arg1	diagrams					811:818	Diameter distribution diagrams	789:818	Diameter distribution diagrams	789:818	Diameter distribution diagrams suggested that the diameter of the nanofibers reduced with the concentration of CMS increasing.
34508720	7	40	theme	thin	950:953	arg1	135.29 nm					966:974	135.29 nm	966:974	135.29 nm	966:974	This is the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend.
34508720	7	40	theme	thin	950:953	arg1	nanofiber					955:963	the thin nanofiber	946:963	the thin nanofiber (135.29 nm) with bead-free	946:990	This is the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend.
34508720	3	41	theme	co-blending	316:326	arg1	PVA					355:357	PVA	355:357	PVA	355:357	The addition of co-blending polymer polyvinyl-alcohol (PVA) was attempted to improve the CMS solution spinnability, which blends from aqueous solution were prepared at different CMS/PVA weight ratios.
34508720	3	41	theme	co-blending	316:326	arg1	polyvinyl-alcohol					336:352	co-blending polymer polyvinyl-alcohol	316:352	co-blending polymer polyvinyl-alcohol (PVA)	316:358	The addition of co-blending polymer polyvinyl-alcohol (PVA) was attempted to improve the CMS solution spinnability, which blends from aqueous solution were prepared at different CMS/PVA weight ratios.
34508720	2	42	theme	carboxymethyl	246:258	arg1	CMS					268:270	CMS	268:270	CMS	268:270	The water-soluble sodium carboxymethyl starch (CMS) with DS 0.31 was prepared.
34508720	2	42	theme	carboxymethyl	246:258	arg1	starch					260:265	The water-soluble sodium carboxymethyl starch	221:265	The water-soluble sodium carboxymethyl starch (CMS) with DS 0.31	221:284	The water-soluble sodium carboxymethyl starch (CMS) with DS 0.31 was prepared.
34508720	3	43	theme	polymer	328:334	arg1	PVA					355:357	PVA	355:357	PVA	355:357	The addition of co-blending polymer polyvinyl-alcohol (PVA) was attempted to improve the CMS solution spinnability, which blends from aqueous solution were prepared at different CMS/PVA weight ratios.
34508720	3	43	theme	polymer	328:334	arg1	polyvinyl-alcohol					336:352	co-blending polymer polyvinyl-alcohol	316:352	co-blending polymer polyvinyl-alcohol (PVA)	316:358	The addition of co-blending polymer polyvinyl-alcohol (PVA) was attempted to improve the CMS solution spinnability, which blends from aqueous solution were prepared at different CMS/PVA weight ratios.
34508720	2	44	theme	sodium	239:244	arg1	CMS					268:270	CMS	268:270	CMS	268:270	The water-soluble sodium carboxymethyl starch (CMS) with DS 0.31 was prepared.
34508720	2	44	theme	sodium	239:244	arg1	starch					260:265	The water-soluble sodium carboxymethyl starch	221:265	The water-soluble sodium carboxymethyl starch (CMS) with DS 0.31	221:284	The water-soluble sodium carboxymethyl starch (CMS) with DS 0.31 was prepared.
34508720	7	45	theme	CMS	1020:1022	arg1	content					1024:1030	the maximal CMS content	1008:1030	the maximal CMS content of 50.0 wt% in the CMS/PVA blend	1008:1063	This is the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend.
34508720	1	46	theme	starch-based	150:161	arg1	nanofibers					173:182	starch-based composite nanofibers	150:182	starch-based composite nanofibers using electrospinning	150:204	A green approach for the preparation of starch-based composite nanofibers using electrospinning was developed.
34508720	0	47	theme	green	94:98	arg1	approach					100:107	a green approach	92:107	a green approach	92:107	Preparation of carboxymethyl starch/polyvinyl-alcohol electrospun composite nanofibers from a green approach.
34508720	2	48	theme	water-soluble	225:237	arg1	CMS					268:270	CMS	268:270	CMS	268:270	The water-soluble sodium carboxymethyl starch (CMS) with DS 0.31 was prepared.
34508720	2	48	theme	water-soluble	225:237	arg1	starch					260:265	The water-soluble sodium carboxymethyl starch	221:265	The water-soluble sodium carboxymethyl starch (CMS) with DS 0.31	221:284	The water-soluble sodium carboxymethyl starch (CMS) with DS 0.31 was prepared.
34508720	1	49	theme	composite	163:171	arg1	nanofibers					173:182	starch-based composite nanofibers	150:182	starch-based composite nanofibers using electrospinning	150:204	A green approach for the preparation of starch-based composite nanofibers using electrospinning was developed.
34508720	7	50	from	blend	1059:1063	arg1	content					1024:1030	the maximal CMS content	1008:1030	the maximal CMS content of 50.0 wt% in the CMS/PVA blend	1008:1063	This is the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend.
34508720	1	51	theme	nanofibers	173:182	arg1	preparation					135:145	the preparation	131:145	the preparation of starch-based composite nanofibers using electrospinning	131:204	A green approach for the preparation of starch-based composite nanofibers using electrospinning was developed.
34508720	7	52	theme	first	928:932	arg1	report					934:939	the first report	924:939	the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend	924:1063	This is the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend.
34508720	7	52	theme	first	928:932	arg1	This					916:919	This	916:919	This	916:919	This is the first report that the thin nanofiber (135.29 nm) with bead-free was obtained at the maximal CMS content of 50.0 wt% in the CMS/PVA blend.
34648803	7	0	theme	strong	1068:1073	arg1	anchoring					1087:1095	strong homogeneous anchoring	1068:1095	strong homogeneous anchoring of the rGO to the polymer matrix	1068:1128	TEM revealed strong homogeneous anchoring of the rGO to the polymer matrix.
34648803	10	1	theme	antibacterial	1317:1329	arg1	drug					1331:1334	the antibacterial drug	1313:1334	the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method	1313:1466	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	10	1	theme	antibacterial	1317:1329	arg1	sulfadiazine					1344:1355	Silver sulfadiazine	1337:1355	Silver sulfadiazine	1337:1355	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	2	2	theme	skin	579:582	arg1	healing					590:596	skin wound healing	579:596	skin wound healing	579:596	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	12	3	theme	adhered	1650:1656	arg1	MC3T3-E1					1636:1643	The MC3T3-E1	1632:1643	The MC3T3-E1	1632:1643	The MC3T3-E1 cell adhered, proliferated, and differentiated well on the composite hydrogels.
34648803	10	4	theme	diffusion	1451:1459	arg1	method					1461:1466	the Franz diffusion method	1441:1466	the Franz diffusion method	1441:1466	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	11	5	theme	composite	1553:1561	arg1	hydrogels					1563:1571	the composite hydrogels	1549:1571	the composite hydrogels	1549:1571	The antibacterial efficacy of the composite hydrogels against pathogens that cause serious skin diseases varied.
34648803	1	6	theme	antibacterial	284:296	arg1	properties					298:307	their outstanding antibacterial properties	266:307	their outstanding antibacterial properties	266:307	Carbohydrate polymers are biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release.
34648803	8	7	theme	agglomeration	1166:1178	arg1	amount					1152:1157	higher amount	1145:1157	with higher amount of rGO agglomeration	1140:1178	However, with higher amount of rGO agglomeration was detected.
34648803	8	7	theme	agglomeration	1166:1178	arg1	agglomeration					1166:1178	rGO agglomeration	1162:1178	rGO agglomeration	1162:1178	However, with higher amount of rGO agglomeration was detected.
34648803	3	8	theme	force	690:694	arg1	microscopy					696:705	atomic force microscopy	683:705	atomic force microscopy (AFM)	683:711	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	8	theme	force	690:694	arg1	AFM					708:710	AFM	708:710	AFM	708:710	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	13	9	theme	composite	1825:1833	arg1	hydrogels					1835:1843	the composite hydrogels	1821:1843	the composite hydrogels	1821:1843	MC3T3-E1 cell also illustrated excellent viability (91%) and proper cylindrical morphologies on the composite hydrogels.
34648803	10	10	theme	drug	1485:1488	arg1	release					1490:1496	maximal drug release	1477:1496	maximal drug release	1477:1496	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	3	11	theme	transmission	714:725	arg1	TEM					748:750	TEM	748:750	TEM	748:750	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	11	theme	transmission	714:725	arg1	microscopy					736:745	transmission electron microscopy	714:745	transmission electron microscopy (TEM)	714:751	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	14	12	theme	skin	1958:1961	arg1	wounds					1963:1968	skin wounds	1958:1968	skin wounds	1958:1968	Hence, the composite hydrogels based on ARX, CS, and rGO are promising biomaterials for treating and caring for skin wounds.
34648803	2	13	theme	Arabinoxylan	337:348	arg1	sheets					405:410	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets	337:410	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets	337:410	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	5	14	dep	AFM	967:969	arg1	evident					975:981	evident	975:981	evident	975:981	The rough morphologies of the composite hydrogels were revealed by SEM and AFM (as evident from the Ra values).
34648803	9	15	from	pHs	1220:1222	arg1	swelling					1200:1207	The % swelling	1194:1207	The % swelling at various pHs (1-13)	1194:1229	The % swelling at various pHs (1-13) revealed that the hydrogels were pH-sensitive.
34648803	7	16	theme	rGO	1104:1106	arg1	anchoring					1087:1095	strong homogeneous anchoring	1068:1095	strong homogeneous anchoring of the rGO to the polymer matrix	1068:1128	TEM revealed strong homogeneous anchoring of the rGO to the polymer matrix.
34648803	1	17	theme	interest	233:240	arg1	lot					226:228	a lot	224:228	a lot of interest in wound healing	224:257	Carbohydrate polymers are biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release.
34648803	1	17	theme	interest	233:240	arg1	interest					233:240	interest	233:240	interest	233:240	Carbohydrate polymers are biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release.
34648803	5	18	theme	Ra	992:993	arg1	values					995:1000	the Ra values	988:1000	the Ra values	988:1000	The rough morphologies of the composite hydrogels were revealed by SEM and AFM (as evident from the Ra values).
34648803	4	19	theme	effective	842:850	arg1	fabrication					852:862	the effective fabrication	838:862	the effective fabrication of the composite hydrogels	838:889	FTIR validated the effective fabrication of the composite hydrogels.
34648803	4	20	theme	composite	871:879	arg1	hydrogels					881:889	the composite hydrogels	867:889	the composite hydrogels	867:889	FTIR validated the effective fabrication of the composite hydrogels.
34648803	3	21	theme	biological	758:767	arg1	assays					769:774	biological assays	758:774	biological assays	758:774	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	9	22	theme	%	1198:1198	arg1	swelling					1200:1207	The % swelling	1194:1207	The % swelling at various pHs (1-13)	1194:1229	The % swelling at various pHs (1-13) revealed that the hydrogels were pH-sensitive.
34648803	5	23	theme	rough	896:900	arg1	morphologies					902:913	The rough morphologies	892:913	The rough morphologies of the composite hydrogels	892:940	The rough morphologies of the composite hydrogels were revealed by SEM and AFM (as evident from the Ra values).
34648803	3	24	theme	Fourier-transform	599:615	arg1	FTIR					640:643	FTIR	640:643	FTIR	640:643	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	24	theme	Fourier-transform	599:615	arg1	spectroscopy					626:637	Fourier-transform infrared spectroscopy	599:637	Fourier-transform infrared spectroscopy (FTIR)	599:644	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	10	25	theme	various	1371:1377	arg1	values					1382:1387	various pH values	1371:1387	various pH values (4.5, 6.8, and 7.4)	1371:1407	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	0	26	theme	drug	88:91	arg1	delivery					93:100	In-vitro drug delivery	79:100	In-vitro drug delivery	79:100	Smart and pH-sensitive rGO/Arabinoxylan/chitosan composite for wound dressing: In-vitro drug delivery, antibacterial activity, and biological activities.
34648803	1	27	theme	biological	180:189	arg1	polymers					167:174	Carbohydrate polymers	154:174	Carbohydrate polymers	154:174	Carbohydrate polymers are biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release.
34648803	1	27	theme	biological	180:189	arg1	macromolecules					191:204	biological macromolecules	180:204	biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release	180:334	Carbohydrate polymers are biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release.
34648803	2	28	theme	composite	510:518	arg1	hydrogels					520:528	composite hydrogels	510:528	composite hydrogels	510:528	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	13	29	theme	proper	1786:1791	arg1	morphologies					1805:1816	proper cylindrical morphologies	1786:1816	proper cylindrical morphologies	1786:1816	MC3T3-E1 cell also illustrated excellent viability (91%) and proper cylindrical morphologies on the composite hydrogels.
34648803	2	30	theme	oxide	393:397	arg1	sheets					405:410	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets	337:410	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets	337:410	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	2	31	theme	reduced	376:382	arg1	rGO					400:402	rGO	400:402	rGO	400:402	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	2	31	theme	reduced	376:382	arg1	oxide					393:397	reduced graphene oxide	376:397	reduced graphene oxide (rGO)	376:403	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	7	32	theme	polymer	1115:1121	arg1	matrix					1123:1128	the polymer matrix	1111:1128	the polymer matrix	1111:1128	TEM revealed strong homogeneous anchoring of the rGO to the polymer matrix.
34648803	0	33	theme	pH-sensitive	10:21	arg1	composite					49:57	pH-sensitive rGO/Arabinoxylan/chitosan composite	10:57	pH-sensitive rGO/Arabinoxylan/chitosan composite	10:57	Smart and pH-sensitive rGO/Arabinoxylan/chitosan composite for wound dressing: In-vitro drug delivery, antibacterial activity, and biological activities.
34648803	1	34	theme	sustained	313:321	arg1	release					328:334	sustained drug release	313:334	sustained drug release	313:334	Carbohydrate polymers are biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release.
34648803	5	35	theme	composite	922:930	arg1	hydrogels					932:940	the composite hydrogels	918:940	the composite hydrogels	918:940	The rough morphologies of the composite hydrogels were revealed by SEM and AFM (as evident from the Ra values).
34648803	14	36	theme	composite	1857:1865	arg1	biomaterials					1917:1928	promising biomaterials	1907:1928	promising biomaterials for treating and caring for skin wounds	1907:1968	Hence, the composite hydrogels based on ARX, CS, and rGO are promising biomaterials for treating and caring for skin wounds.
34648803	14	36	theme	composite	1857:1865	arg1	hydrogels					1867:1875	the composite hydrogels	1853:1875	the composite hydrogels based on ARX, CS, and rGO	1853:1901	Hence, the composite hydrogels based on ARX, CS, and rGO are promising biomaterials for treating and caring for skin wounds.
34648803	12	37	theme	composite	1704:1712	arg1	hydrogels					1714:1722	the composite hydrogels	1700:1722	the composite hydrogels	1700:1722	The MC3T3-E1 cell adhered, proliferated, and differentiated well on the composite hydrogels.
34648803	2	38	theme	tetraethyl	448:457	arg1	TEOS					474:477	TEOS	474:477	TEOS	474:477	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	2	38	theme	tetraethyl	448:457	arg1	orthosilicate					459:471	tetraethyl orthosilicate	448:471	tetraethyl orthosilicate (TEOS)	448:478	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	2	38	theme	tetraethyl	448:457	arg1	crosslinker					485:495	a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing	483:596	a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing	483:596	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	10	39	theme	PBS	1412:1414	arg1	solution					1416:1423	PBS solution	1412:1423	PBS solution	1412:1423	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	2	40	theme	Chitosan	357:364	arg1	sheets					405:410	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets	337:410	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets	337:410	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	0	41	theme	wound	63:67	arg1	dressing					69:76	wound dressing	63:76	wound dressing	63:76	Smart and pH-sensitive rGO/Arabinoxylan/chitosan composite for wound dressing: In-vitro drug delivery, antibacterial activity, and biological activities.
34648803	14	42	theme	promising	1907:1915	arg1	biomaterials					1917:1928	promising biomaterials	1907:1928	promising biomaterials for treating and caring for skin wounds	1907:1968	Hence, the composite hydrogels based on ARX, CS, and rGO are promising biomaterials for treating and caring for skin wounds.
34648803	14	42	theme	promising	1907:1915	arg1	hydrogels					1867:1875	the composite hydrogels	1853:1875	the composite hydrogels based on ARX, CS, and rGO	1853:1901	Hence, the composite hydrogels based on ARX, CS, and rGO are promising biomaterials for treating and caring for skin wounds.
34648803	11	43	theme	skin	1610:1613	arg1	diseases					1615:1622	serious skin diseases	1602:1622	serious skin diseases	1602:1622	The antibacterial efficacy of the composite hydrogels against pathogens that cause serious skin diseases varied.
34648803	10	44	theme	controlled	1282:1291	arg1	profile					1301:1307	The controlled release profile	1278:1307	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method	1278:1466	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	0	45	dep	Smart	0:4	arg1	activities					142:151	biological activities	131:151	biological activities	131:151	Smart and pH-sensitive rGO/Arabinoxylan/chitosan composite for wound dressing: In-vitro drug delivery, antibacterial activity, and biological activities.
34648803	0	45	dep	Smart	0:4	arg1	delivery					93:100	In-vitro drug delivery	79:100	In-vitro drug delivery	79:100	Smart and pH-sensitive rGO/Arabinoxylan/chitosan composite for wound dressing: In-vitro drug delivery, antibacterial activity, and biological activities.
34648803	0	45	dep	Smart	0:4	arg1	activity					117:124	antibacterial activity	103:124	antibacterial activity	103:124	Smart and pH-sensitive rGO/Arabinoxylan/chitosan composite for wound dressing: In-vitro drug delivery, antibacterial activity, and biological activities.
34648803	6	46	theme	roughest	1037:1044	arg1	surface					1046:1052	the roughest surface	1033:1052	the roughest surface	1033:1052	ATC-4 was discovered to have the roughest surface.
34648803	3	47	theme	atomic	683:688	arg1	microscopy					696:705	atomic force microscopy	683:705	atomic force microscopy (AFM)	683:711	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	47	theme	atomic	683:688	arg1	AFM					708:710	AFM	708:710	AFM	708:710	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	2	48	theme	wound	584:588	arg1	healing					590:596	skin wound healing	579:596	skin wound healing	579:596	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	2	49	from	potential	547:555	arg1	dressing					566:573	wound dressing	560:573	wound dressing	560:573	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	1	50	theme	outstanding	272:282	arg1	properties					298:307	their outstanding antibacterial properties	266:307	their outstanding antibacterial properties	266:307	Carbohydrate polymers are biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release.
34648803	10	51	theme	Franz	1445:1449	arg1	method					1461:1466	the Franz diffusion method	1441:1466	the Franz diffusion method	1441:1466	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	11	52	theme	hydrogels	1563:1571	arg1	efficacy					1537:1544	The antibacterial efficacy	1519:1544	The antibacterial efficacy of the composite hydrogels against pathogens that cause serious skin diseases	1519:1622	The antibacterial efficacy of the composite hydrogels against pathogens that cause serious skin diseases varied.
34648803	8	53	theme	rGO	1162:1164	arg1	agglomeration					1166:1178	rGO agglomeration	1162:1178	rGO agglomeration	1162:1178	However, with higher amount of rGO agglomeration was detected.
34648803	5	54	from	values	995:1000	arg1	evident					975:981	evident	975:981	evident	975:981	The rough morphologies of the composite hydrogels were revealed by SEM and AFM (as evident from the Ra values).
34648803	10	55	theme	Silver	1337:1342	arg1	drug					1331:1334	the antibacterial drug	1313:1334	the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method	1313:1466	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	10	55	theme	Silver	1337:1342	arg1	sulfadiazine					1344:1355	Silver sulfadiazine	1337:1355	Silver sulfadiazine	1337:1355	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	3	56	theme	electron	656:663	arg1	SEM					677:679	SEM	677:679	SEM	677:679	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	56	theme	electron	656:663	arg1	microscopy					665:674	scanning electron microscopy	647:674	scanning electron microscopy (SEM)	647:680	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	10	57	theme	maximal	1477:1483	arg1	release					1490:1496	maximal drug release	1477:1496	maximal drug release	1477:1496	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	3	58	theme	electron	727:734	arg1	TEM					748:750	TEM	748:750	TEM	748:750	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	58	theme	electron	727:734	arg1	microscopy					736:745	transmission electron microscopy	714:745	transmission electron microscopy (TEM)	714:751	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	0	59	theme	biological	131:140	arg1	activities					142:151	biological activities	131:151	biological activities	131:151	Smart and pH-sensitive rGO/Arabinoxylan/chitosan composite for wound dressing: In-vitro drug delivery, antibacterial activity, and biological activities.
34648803	4	60	theme	hydrogels	881:889	arg1	fabrication					852:862	the effective fabrication	838:862	the effective fabrication of the composite hydrogels	838:889	FTIR validated the effective fabrication of the composite hydrogels.
34648803	8	61	theme	with	1140:1143	arg1	amount					1152:1157	higher amount	1145:1157	with higher amount of rGO agglomeration	1140:1178	However, with higher amount of rGO agglomeration was detected.
34648803	8	61	theme	with	1140:1143	arg1	agglomeration					1166:1178	rGO agglomeration	1162:1178	rGO agglomeration	1162:1178	However, with higher amount of rGO agglomeration was detected.
34648803	2	62	theme	wound	560:564	arg1	dressing					566:573	wound dressing	560:573	wound dressing	560:573	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	6	63	contain	have	1028:1031	arg2	surface					1046:1052	the roughest surface	1033:1052	the roughest surface	1033:1052	ATC-4 was discovered to have the roughest surface.
34648803	6	63	contain	have	1028:1031	arg1	ATC-4					1004:1008	ATC-4	1004:1008	ATC-4	1004:1008	ATC-4 was discovered to have the roughest surface.
34648803	13	64	theme	cylindrical	1793:1803	arg1	morphologies					1805:1816	proper cylindrical morphologies	1786:1816	proper cylindrical morphologies	1786:1816	MC3T3-E1 cell also illustrated excellent viability (91%) and proper cylindrical morphologies on the composite hydrogels.
34648803	3	65	theme	infrared	617:624	arg1	FTIR					640:643	FTIR	640:643	FTIR	640:643	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	65	theme	infrared	617:624	arg1	spectroscopy					626:637	Fourier-transform infrared spectroscopy	599:637	Fourier-transform infrared spectroscopy (FTIR)	599:644	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	1	66	from	lot	226:228	arg1	healing					251:257	wound healing	245:257	wound healing	245:257	Carbohydrate polymers are biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release.
34648803	0	67	theme	In-vitro	79:86	arg1	delivery					93:100	In-vitro drug delivery	79:100	In-vitro drug delivery	79:100	Smart and pH-sensitive rGO/Arabinoxylan/chitosan composite for wound dressing: In-vitro drug delivery, antibacterial activity, and biological activities.
34648803	1	68	theme	Carbohydrate	154:165	arg1	polymers					167:174	Carbohydrate polymers	154:174	Carbohydrate polymers	154:174	Carbohydrate polymers are biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release.
34648803	1	68	theme	Carbohydrate	154:165	arg1	macromolecules					191:204	biological macromolecules	180:204	biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release	180:334	Carbohydrate polymers are biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release.
34648803	3	69	theme	composite	802:810	arg1	hydrogels					812:820	the composite hydrogels	798:820	the composite hydrogels	798:820	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	9	70	theme	various	1212:1218	arg1	pHs					1220:1222	various pHs	1212:1222	various pHs (1-13)	1212:1229	The % swelling at various pHs (1-13) revealed that the hydrogels were pH-sensitive.
34648803	9	70	theme	various	1212:1218	arg1	1-13					1225:1228	1-13	1225:1228	1-13	1225:1228	The % swelling at various pHs (1-13) revealed that the hydrogels were pH-sensitive.
34648803	3	71	theme	scanning	647:654	arg1	SEM					677:679	SEM	677:679	SEM	677:679	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	71	theme	scanning	647:654	arg1	microscopy					665:674	scanning electron microscopy	647:674	scanning electron microscopy (SEM)	647:680	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	0	72	theme	antibacterial	103:115	arg1	activity					117:124	antibacterial activity	103:124	antibacterial activity	103:124	Smart and pH-sensitive rGO/Arabinoxylan/chitosan composite for wound dressing: In-vitro drug delivery, antibacterial activity, and biological activities.
34648803	5	73	theme	hydrogels	932:940	arg1	morphologies					902:913	The rough morphologies	892:913	The rough morphologies of the composite hydrogels	892:940	The rough morphologies of the composite hydrogels were revealed by SEM and AFM (as evident from the Ra values).
34648803	3	74	used	used	781:784	arg2	spectroscopy					626:637	Fourier-transform infrared spectroscopy	599:637	Fourier-transform infrared spectroscopy (FTIR)	599:644	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	74	used	used	781:784	arg2	SEM					677:679	SEM	677:679	SEM	677:679	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	74	used	used	781:784	arg2	microscopy					696:705	atomic force microscopy	683:705	atomic force microscopy (AFM)	683:711	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	74	used	used	781:784	arg2	microscopy					665:674	scanning electron microscopy	647:674	scanning electron microscopy (SEM)	647:680	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	74	used	used	781:784	arg2	AFM					708:710	AFM	708:710	AFM	708:710	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	74	used	used	781:784	arg2	assays					769:774	biological assays	758:774	biological assays	758:774	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	74	used	used	781:784	arg2	microscopy					736:745	transmission electron microscopy	714:745	transmission electron microscopy (TEM)	714:751	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	74	used	used	781:784	arg2	FTIR					640:643	FTIR	640:643	FTIR	640:643	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	3	74	used	used	781:784	arg2	TEM					748:750	TEM	748:750	TEM	748:750	Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and biological assays were used to evaluate the composite hydrogels.
34648803	13	75	theme	excellent	1756:1764	arg1	viability					1766:1774	excellent viability	1756:1774	excellent viability (91%)	1756:1780	MC3T3-E1 cell also illustrated excellent viability (91%) and proper cylindrical morphologies on the composite hydrogels.
34648803	13	75	theme	excellent	1756:1764	arg1	%					1779:1779	91%	1777:1779	91%	1777:1779	MC3T3-E1 cell also illustrated excellent viability (91%) and proper cylindrical morphologies on the composite hydrogels.
34648803	8	76	theme	higher	1145:1150	arg1	amount					1152:1157	higher amount	1145:1157	with higher amount of rGO agglomeration	1140:1178	However, with higher amount of rGO agglomeration was detected.
34648803	8	76	theme	higher	1145:1150	arg1	agglomeration					1166:1178	rGO agglomeration	1162:1178	rGO agglomeration	1162:1178	However, with higher amount of rGO agglomeration was detected.
34648803	2	77	theme	graphene	384:391	arg1	rGO					400:402	rGO	400:402	rGO	400:402	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	2	77	theme	graphene	384:391	arg1	oxide					393:397	reduced graphene oxide	376:397	reduced graphene oxide (rGO)	376:403	Arabinoxylan (ARX), Chitosan (CS), and reduced graphene oxide (rGO) sheets were combined and crosslinked using tetraethyl orthosilicate (TEOS) as a crosslinker to fabricate composite hydrogels and assess their potential in wound dressing for skin wound healing.
34648803	10	78	dep	values	1382:1387	arg1	6.8					1395:1397	6.8	1395:1397	6.8	1395:1397	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	10	78	dep	values	1382:1387	arg1	7.4					1404:1406	7.4	1404:1406	7.4	1404:1406	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	10	79	theme	pH	1379:1380	arg1	values					1382:1387	various pH values	1371:1387	various pH values (4.5, 6.8, and 7.4)	1371:1407	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	13	80	theme	MC3T3-E1	1725:1732	arg1	cell					1734:1737	MC3T3-E1 cell	1725:1737	MC3T3-E1 cell	1725:1737	MC3T3-E1 cell also illustrated excellent viability (91%) and proper cylindrical morphologies on the composite hydrogels.
34648803	0	81	theme	rGO/Arabinoxylan/chitosan	23:47	arg1	composite					49:57	pH-sensitive rGO/Arabinoxylan/chitosan composite	10:57	pH-sensitive rGO/Arabinoxylan/chitosan composite	10:57	Smart and pH-sensitive rGO/Arabinoxylan/chitosan composite for wound dressing: In-vitro drug delivery, antibacterial activity, and biological activities.
34648803	1	82	theme	drug	323:326	arg1	release					328:334	sustained drug release	313:334	sustained drug release	313:334	Carbohydrate polymers are biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release.
34648803	7	83	theme	homogeneous	1075:1085	arg1	anchoring					1087:1095	strong homogeneous anchoring	1068:1095	strong homogeneous anchoring of the rGO to the polymer matrix	1068:1128	TEM revealed strong homogeneous anchoring of the rGO to the polymer matrix.
34648803	11	84	theme	serious	1602:1608	arg1	diseases					1615:1622	serious skin diseases	1602:1622	serious skin diseases	1602:1622	The antibacterial efficacy of the composite hydrogels against pathogens that cause serious skin diseases varied.
34648803	10	85	theme	release	1293:1299	arg1	profile					1301:1307	The controlled release profile	1278:1307	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method	1278:1466	The controlled release profile for the antibacterial drug (Silver sulfadiazine) evaluated at various pH values (4.5, 6.8, and 7.4) in PBS solution and 37 °C using the Franz diffusion method revealed maximal drug release at pH 7.4 and 37 °C.
34648803	1	86	theme	wound	245:249	arg1	healing					251:257	wound healing	245:257	wound healing	245:257	Carbohydrate polymers are biological macromolecules that have sparked a lot of interest in wound healing due to their outstanding antibacterial properties and sustained drug release.
34648803	11	87	theme	antibacterial	1523:1535	arg1	efficacy					1537:1544	The antibacterial efficacy	1519:1544	The antibacterial efficacy of the composite hydrogels against pathogens that cause serious skin diseases	1519:1622	The antibacterial efficacy of the composite hydrogels against pathogens that cause serious skin diseases varied.
33843218	5	0	with	substrates	899:908	arg1	characteristics					936:950	different structural characteristics	915:950	different structural characteristics	915:950	The RS substrates with different structural characteristics enabled varying growth of Bifidobacterium spp., Eubacterium spp., and Faecalibacterium spp.
33843218	0	1	with	Substrates	30:39	arg1	Features					67:74	Different Structural Features	46:74	Different Structural Features	46:74	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	2	2	theme	acids	389:393	arg1	composition					402:412	short-chain fatty acids (SCFA) composition	371:412	short-chain fatty acids (SCFA) composition	371:412	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	2	3	theme	period	557:562	arg1	h					526:526	24 h	523:526	24 h of the in vitro fermentation period	523:562	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	6	4	from	differences	1106:1116	arg1	fermentation					1135:1146	the fermentation	1131:1146	the fermentation of RS with different structural features	1131:1187	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	6	4	from	differences	1106:1116	arg1	SCFA					1121:1124	SCFA	1121:1124	SCFA from the fermentation of RS with different structural features	1121:1187	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	2	5	theme	fatty	383:387	arg1	acids					389:393	short-chain fatty acids	371:393	short-chain fatty acids (SCFA) composition	371:412	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	2	5	theme	fatty	383:387	arg1	SCFA					396:399	SCFA	396:399	SCFA	396:399	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	5	6	theme	varying	960:966	arg1	growth					968:973	varying growth	960:973	varying growth of Bifidobacterium spp., Eubacterium spp., and Faecalibacterium spp	960:1041	The RS substrates with different structural characteristics enabled varying growth of Bifidobacterium spp., Eubacterium spp., and Faecalibacterium spp.
33843218	0	7	theme	Short-Chain	103:113	arg1	Acids					121:125	Short-Chain Fatty Acids	103:125	Short-Chain Fatty Acids	103:125	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	4	8	theme	SCFA	782:785	arg1	levels					740:745	significantly higher levels	719:745	significantly higher levels of butyrate, propionate, and total SCFA	719:785	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	6	9	from	fermentation	1135:1146	arg1	differences					1106:1116	the differences	1102:1116	the differences in SCFA from the fermentation of RS with different structural features	1102:1187	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	6	9	from	fermentation	1135:1146	arg1	SCFA					1121:1124	SCFA	1121:1124	SCFA from the fermentation of RS with different structural features	1121:1187	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	5	10	theme	spp.	994:997	arg1	growth					968:973	varying growth	960:973	varying growth of Bifidobacterium spp., Eubacterium spp., and Faecalibacterium spp	960:1041	The RS substrates with different structural characteristics enabled varying growth of Bifidobacterium spp., Eubacterium spp., and Faecalibacterium spp.
33843218	2	11	theme	in	535:536	arg1	period					557:562	the in vitro fermentation period	531:562	the in vitro fermentation period	531:562	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	6	12	theme	rational	1218:1225	arg1	design					1227:1232	the rational design	1214:1232	the rational design of foods containing resistant starch with targeted health benefits	1214:1299	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	4	13	theme	total	776:780	arg1	SCFA					782:785	total SCFA	776:785	total SCFA	776:785	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	1	14	theme	native	276:281	arg1	starches					334:341	both native and pullulanase-debranched and acid-hydrolyzed pea starches	271:341	both native and pullulanase-debranched and acid-hydrolyzed pea starches	271:341	Resistant starches (RSs) with different structural features were isolated from both native and pullulanase-debranched and acid-hydrolyzed pea starches.
33843218	0	15	theme	Acids	121:125	arg1	Production					89:98	the Production	85:98	the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation	85:180	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	5	16	theme	different	915:923	arg1	characteristics					936:950	different structural characteristics	915:950	different structural characteristics	915:950	The RS substrates with different structural characteristics enabled varying growth of Bifidobacterium spp., Eubacterium spp., and Faecalibacterium spp.
33843218	4	17	theme	resistant	848:856	arg1	starches					858:865	resistant starches	848:865	resistant starches	848:865	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	4	17	theme	resistant	848:856	arg1	substrates					880:889	substrates	880:889	substrates	880:889	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	4	18	theme	propionate	760:769	arg1	levels					740:745	significantly higher levels	719:745	significantly higher levels of butyrate, propionate, and total SCFA	719:785	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	2	19	theme	microbiota	415:424	arg1	communities					426:436	microbiota communities	415:436	microbiota communities	415:436	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	0	20	theme	Fatty	115:119	arg1	Acids					121:125	Short-Chain Fatty Acids	103:125	Short-Chain Fatty Acids	103:125	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	5	21	theme	spp.	1012:1015	arg1	growth					968:973	varying growth	960:973	varying growth of Bifidobacterium spp., Eubacterium spp., and Faecalibacterium spp	960:1041	The RS substrates with different structural characteristics enabled varying growth of Bifidobacterium spp., Eubacterium spp., and Faecalibacterium spp.
33843218	0	22	theme	Pea	9:11	arg1	Substrates					30:39	Isolated Pea Resistant Starch Substrates	0:39	Isolated Pea Resistant Starch Substrates with Different Structural Features	0:74	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	6	23	with	fermentation	1135:1146	arg1	features					1180:1187	different structural features	1159:1187	different structural features	1159:1187	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	3	24	theme	microbial	587:595	arg1	fermentation					597:608	The microbial fermentation	583:608	The microbial fermentation	583:608	The microbial fermentation clearly caused numerous cracks and erosion on the RS granule surface.
33843218	1	25	theme	Resistant	192:200	arg1	RSs					212:214	RSs	212:214	RSs	212:214	Resistant starches (RSs) with different structural features were isolated from both native and pullulanase-debranched and acid-hydrolyzed pea starches.
33843218	1	25	theme	Resistant	192:200	arg1	starches					202:209	Resistant starches	192:209	Resistant starches (RSs) with different structural features	192:250	Resistant starches (RSs) with different structural features were isolated from both native and pullulanase-debranched and acid-hydrolyzed pea starches.
33843218	0	26	theme	Isolated	0:7	arg1	Substrates					30:39	Isolated Pea Resistant Starch Substrates	0:39	Isolated Pea Resistant Starch Substrates with Different Structural Features	0:74	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	6	27	theme	targeted	1276:1283	arg1	benefits					1292:1299	targeted health benefits	1276:1299	targeted health benefits	1276:1299	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	0	28	theme	Starch	23:28	arg1	Substrates					30:39	Isolated Pea Resistant Starch Substrates	0:39	Isolated Pea Resistant Starch Substrates with Different Structural Features	0:74	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	1	29	theme	pullulanase-debranched	287:308	arg1	starches					334:341	both native and pullulanase-debranched and acid-hydrolyzed pea starches	271:341	both native and pullulanase-debranched and acid-hydrolyzed pea starches	271:341	Resistant starches (RSs) with different structural features were isolated from both native and pullulanase-debranched and acid-hydrolyzed pea starches.
33843218	0	30	theme	Metabolism	131:140	arg1	Production					89:98	the Production	85:98	the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation	85:180	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	6	31	theme	health	1285:1290	arg1	benefits					1292:1299	targeted health benefits	1276:1299	targeted health benefits	1276:1299	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	2	32	theme	structural	443:452	arg1	characteristics					454:468	structural characteristics	443:468	structural characteristics	443:468	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	0	33	theme	Resistant	13:21	arg1	Substrates					30:39	Isolated Pea Resistant Starch Substrates	0:39	Isolated Pea Resistant Starch Substrates with Different Structural Features	0:74	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	4	34	used	used	872:875	arg2	substrates					880:889	substrates	880:889	substrates	880:889	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	4	34	used	used	872:875	arg2	starches					858:865	resistant starches	848:865	resistant starches	848:865	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	0	35	from	Production	89:98	arg1	Fermentation					169:180	Anaerobic Fermentation	159:180	Anaerobic Fermentation	159:180	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	6	36	from	discrepancy	1048:1058	arg1	communities					1074:1084	microbiota communities	1063:1084	microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features	1063:1187	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	1	37	theme	acid-hydrolyzed	314:328	arg1	starches					334:341	both native and pullulanase-debranched and acid-hydrolyzed pea starches	271:341	both native and pullulanase-debranched and acid-hydrolyzed pea starches	271:341	Resistant starches (RSs) with different structural features were isolated from both native and pullulanase-debranched and acid-hydrolyzed pea starches.
33843218	0	38	theme	Microbiota	145:154	arg1	Metabolism					131:140	Metabolism	131:140	Metabolism of Microbiota	131:154	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	0	38	theme	Microbiota	145:154	arg1	Acids					121:125	Short-Chain Fatty Acids	103:125	Short-Chain Fatty Acids	103:125	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	6	39	theme	different	1159:1167	arg1	features					1180:1187	different structural features	1159:1187	different structural features	1159:1187	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	3	40	theme	numerous	625:632	arg1	cracks					634:639	numerous cracks	625:639	numerous cracks	625:639	The microbial fermentation clearly caused numerous cracks and erosion on the RS granule surface.
33843218	1	41	theme	pea	330:332	arg1	starches					334:341	both native and pullulanase-debranched and acid-hydrolyzed pea starches	271:341	both native and pullulanase-debranched and acid-hydrolyzed pea starches	271:341	Resistant starches (RSs) with different structural features were isolated from both native and pullulanase-debranched and acid-hydrolyzed pea starches.
33843218	2	42	theme	fermentation	544:555	arg1	period					557:562	the in vitro fermentation period	531:562	the in vitro fermentation period	531:562	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	3	43	theme	RS	660:661	arg1	surface					671:677	the RS granule surface	656:677	the RS granule surface	656:677	The microbial fermentation clearly caused numerous cracks and erosion on the RS granule surface.
33843218	4	44	theme	in	815:816	arg1	fermentation					830:841	in vitro fecal fermentation	815:841	in vitro fecal fermentation	815:841	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	4	45	dep	in	815:816	arg1	vitro					818:822	vitro	818:822	vitro	818:822	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	0	46	theme	Structural	56:65	arg1	Features					67:74	Different Structural Features	46:74	Different Structural Features	46:74	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	0	47	theme	Anaerobic	159:167	arg1	Fermentation					169:180	Anaerobic Fermentation	159:180	Anaerobic Fermentation	159:180	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	3	48	theme	granule	663:669	arg1	surface					671:677	the RS granule surface	656:677	the RS granule surface	656:677	The microbial fermentation clearly caused numerous cracks and erosion on the RS granule surface.
33843218	4	49	theme	fermentation	830:841	arg1	h					810:810	24 h	807:810	24 h of in vitro fecal fermentation	807:841	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	2	50	theme	short-chain	371:381	arg1	acids					389:393	short-chain fatty acids	371:393	short-chain fatty acids (SCFA) composition	371:412	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	2	50	theme	short-chain	371:381	arg1	SCFA					396:399	SCFA	396:399	SCFA	396:399	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	0	51	theme	Different	46:54	arg1	Features					67:74	Different Structural Features	46:74	Different Structural Features	46:74	Isolated Pea Resistant Starch Substrates with Different Structural Features Modulate the Production of Short-Chain Fatty Acids and Metabolism of Microbiota in Anaerobic Fermentation In Vitro.
33843218	6	52	contain	containing	1243:1252	arg1	foods					1237:1241	foods	1237:1241	foods containing resistant starch with targeted health benefits	1237:1299	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	6	52	contain	containing	1243:1252	arg2	starch					1264:1269	resistant starch	1254:1269	resistant starch	1254:1269	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	1	53	with	starches	202:209	arg1	features					243:250	different structural features	222:250	different structural features	222:250	Resistant starches (RSs) with different structural features were isolated from both native and pullulanase-debranched and acid-hydrolyzed pea starches.
33843218	2	54	theme	fermenta	491:498	arg1	residues					500:507	the corresponding fermenta residues	473:507	the corresponding fermenta residues	473:507	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	4	55	theme	fecal	824:828	arg1	fermentation					830:841	in vitro fecal fermentation	815:841	in vitro fecal fermentation	815:841	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	4	56	theme	higher	733:738	arg1	levels					740:745	significantly higher levels	719:745	significantly higher levels of butyrate, propionate, and total SCFA	719:785	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	5	57	theme	structural	925:934	arg1	characteristics					936:950	different structural characteristics	915:950	different structural characteristics	915:950	The RS substrates with different structural characteristics enabled varying growth of Bifidobacterium spp., Eubacterium spp., and Faecalibacterium spp.
33843218	6	58	theme	resistant	1254:1262	arg1	starch					1264:1269	resistant starch	1254:1269	resistant starch	1254:1269	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	4	59	theme	positive	701:708	arg1	control					710:716	the positive control	697:716	the positive control	697:716	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	4	60	theme	butyrate	750:757	arg1	levels					740:745	significantly higher levels	719:745	significantly higher levels of butyrate, propionate, and total SCFA	719:785	In comparison to the positive control, significantly higher levels of butyrate, propionate, and total SCFA were produced after 24 h of in vitro fecal fermentation when resistant starches were used as substrates.
33843218	6	61	theme	RS	1151:1152	arg1	fermentation					1135:1146	the fermentation	1131:1146	the fermentation of RS with different structural features	1131:1187	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	1	62	theme	different	222:230	arg1	features					243:250	different structural features	222:250	different structural features	222:250	Resistant starches (RSs) with different structural features were isolated from both native and pullulanase-debranched and acid-hydrolyzed pea starches.
33843218	1	63	attach	isolated	257:264	arg1	starches					334:341	both native and pullulanase-debranched and acid-hydrolyzed pea starches	271:341	both native and pullulanase-debranched and acid-hydrolyzed pea starches	271:341	Resistant starches (RSs) with different structural features were isolated from both native and pullulanase-debranched and acid-hydrolyzed pea starches.
33843218	1	63	attach	isolated	257:264	arg2	RSs					212:214	RSs	212:214	RSs	212:214	Resistant starches (RSs) with different structural features were isolated from both native and pullulanase-debranched and acid-hydrolyzed pea starches.
33843218	1	63	attach	isolated	257:264	arg2	starches					202:209	Resistant starches	192:209	Resistant starches (RSs) with different structural features	192:250	Resistant starches (RSs) with different structural features were isolated from both native and pullulanase-debranched and acid-hydrolyzed pea starches.
33843218	2	64	dep	in	535:536	arg1	vitro					538:542	vitro	538:542	vitro	538:542	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	2	65	theme	microscopic	350:360	arg1	changes					362:368	Their microscopic changes	344:368	Their microscopic changes	344:368	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	6	66	theme	structural	1169:1178	arg1	features					1180:1187	different structural features	1159:1187	different structural features	1159:1187	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	1	67	theme	structural	232:241	arg1	features					243:250	different structural features	222:250	different structural features	222:250	Resistant starches (RSs) with different structural features were isolated from both native and pullulanase-debranched and acid-hydrolyzed pea starches.
33843218	2	68	theme	h	526:526	arg1	end					516:518	the end	512:518	the end of 24 h of the in vitro fermentation period	512:562	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	6	69	theme	microbiota	1063:1072	arg1	communities					1074:1084	microbiota communities	1063:1084	microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features	1063:1187	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	6	70	theme	foods	1237:1241	arg1	design					1227:1232	the rational design	1214:1232	the rational design of foods containing resistant starch with targeted health benefits	1214:1299	The discrepancy in microbiota communities associated with the differences in SCFA from the fermentation of RS with different structural features would be critical toward the rational design of foods containing resistant starch with targeted health benefits.
33843218	5	71	theme	RS	896:897	arg1	substrates					899:908	The RS substrates	892:908	The RS substrates with different structural characteristics	892:950	The RS substrates with different structural characteristics enabled varying growth of Bifidobacterium spp., Eubacterium spp., and Faecalibacterium spp.
33843218	2	72	theme	residues	500:507	arg1	characteristics					454:468	structural characteristics	443:468	structural characteristics	443:468	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	2	72	theme	residues	500:507	arg1	changes					362:368	Their microscopic changes	344:368	Their microscopic changes	344:368	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	2	72	theme	residues	500:507	arg1	communities					426:436	microbiota communities	415:436	microbiota communities	415:436	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	2	72	theme	residues	500:507	arg1	composition					402:412	short-chain fatty acids (SCFA) composition	371:412	short-chain fatty acids (SCFA) composition	371:412	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
33843218	5	73	theme	spp	1039:1041	arg1	growth					968:973	varying growth	960:973	varying growth of Bifidobacterium spp., Eubacterium spp., and Faecalibacterium spp	960:1041	The RS substrates with different structural characteristics enabled varying growth of Bifidobacterium spp., Eubacterium spp., and Faecalibacterium spp.
33843218	2	74	theme	corresponding	477:489	arg1	residues					500:507	the corresponding fermenta residues	473:507	the corresponding fermenta residues	473:507	Their microscopic changes, short-chain fatty acids (SCFA) composition, microbiota communities, and structural characteristics of the corresponding fermenta residues by the end of 24 h of the in vitro fermentation period were investigated.
32551624	0	0	theme	Composition	104:114	arg1	Modulators					75:84	Modulators	75:84	Modulators of the Microbiota Composition	75:114	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition and Their Activity: A Comparison Using the In Vitro Model of the Human Colon TIM-2.
32551624	1	1	theme	colon	343:347	arg1	model					349:353	the TIM-2 in vitro colon model	324:353	the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly	324:407	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	0	2	theme	Human	181:185	arg1	TIM-2					193:197	the Human Colon TIM-2	177:197	the Human Colon TIM-2	177:197	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition and Their Activity: A Comparison Using the In Vitro Model of the Human Colon TIM-2.
32551624	3	3	theme	fatty	593:597	arg1	acid					619:622	short-chain fatty acids/total organic acid	581:622	short-chain fatty acids/total organic acid	581:622	GGMOS resulted in higher organic acid productions and higher short-chain fatty acids/total organic acid molar ratios.
32551624	0	4	theme	Microbiota	93:102	arg1	Composition					104:114	the Microbiota Composition	89:114	the Microbiota Composition	89:114	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition and Their Activity: A Comparison Using the In Vitro Model of the Human Colon TIM-2.
32551624	0	5	theme	TIM-2	193:197	arg1	Model					168:172	the In Vitro Model	155:172	the In Vitro Model of the Human Colon TIM-2	155:197	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition and Their Activity: A Comparison Using the In Vitro Model of the Human Colon TIM-2.
32551624	7	6	theme	further	1253:1259	arg1	research					1261:1268	further research	1253:1268	further research using these oligosaccharides as "carriers" of desired substituents	1253:1335	This suggests that GGMOS would be more suitable substrates for the elderly, even though GGMOS_Ac promoted positive effects that support the interest of further research using these oligosaccharides as "carriers" of desired substituents.
32551624	6	7	theme	genera	1031:1036	arg1	diversities					1004:1014	higher bacterial diversities	987:1014	higher bacterial diversities	987:1014	However, higher bacterial diversities and numbers of genera such as Oscillospira and Lachnospira were found with GGMOS_Ac.
32551624	6	7	theme	genera	1031:1036	arg1	Lachnospira					1063:1073	Lachnospira	1063:1073	Lachnospira	1063:1073	However, higher bacterial diversities and numbers of genera such as Oscillospira and Lachnospira were found with GGMOS_Ac.
32551624	6	7	theme	genera	1031:1036	arg1	Oscillospira					1046:1057	Oscillospira	1046:1057	Oscillospira	1046:1057	However, higher bacterial diversities and numbers of genera such as Oscillospira and Lachnospira were found with GGMOS_Ac.
32551624	6	7	theme	genera	1031:1036	arg1	numbers					1020:1026	numbers	1020:1026	numbers	1020:1026	However, higher bacterial diversities and numbers of genera such as Oscillospira and Lachnospira were found with GGMOS_Ac.
32551624	0	8	theme	Colon	187:191	arg1	TIM-2					193:197	the Human Colon TIM-2	177:197	the Human Colon TIM-2	177:197	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition and Their Activity: A Comparison Using the In Vitro Model of the Human Colon TIM-2.
32551624	4	9	theme	GGMOS	720:724	arg1	fermentation					726:737	GGMOS fermentation	720:737	GGMOS fermentation	720:737	Although comparable Actinobacteria abundances were observed with both substrates, GGMOS fermentation led to higher Firmicutes/Bacteroidetes ratios and lower Proteobacteria percentages than GGMOS_Ac.
32551624	2	10	theme	efflux	498:503	arg1	SIEM					513:516	SIEM	513:516	SIEM	513:516	The effects on the microbiota and their activity were also compared to a standard ileal efflux medium (SIEM).
32551624	2	10	theme	efflux	498:503	arg1	medium					505:510	a standard ileal efflux medium	481:510	a standard ileal efflux medium (SIEM)	481:517	The effects on the microbiota and their activity were also compared to a standard ileal efflux medium (SIEM).
32551624	1	11	dep	in	334:335	arg1	vitro					337:341	vitro	337:341	vitro	337:341	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	7	12	theme	positive	1207:1214	arg1	effects					1216:1222	positive effects	1207:1222	positive effects that support the interest of further research using these oligosaccharides as "carriers" of desired substituents	1207:1335	This suggests that GGMOS would be more suitable substrates for the elderly, even though GGMOS_Ac promoted positive effects that support the interest of further research using these oligosaccharides as "carriers" of desired substituents.
32551624	4	13	theme	Proteobacteria	795:808	arg1	percentages					810:820	lower Proteobacteria percentages	789:820	lower Proteobacteria percentages	789:820	Although comparable Actinobacteria abundances were observed with both substrates, GGMOS fermentation led to higher Firmicutes/Bacteroidetes ratios and lower Proteobacteria percentages than GGMOS_Ac.
32551624	4	14	theme	comparable	647:656	arg1	abundances					673:682	comparable Actinobacteria abundances	647:682	comparable Actinobacteria abundances	647:682	Although comparable Actinobacteria abundances were observed with both substrates, GGMOS fermentation led to higher Firmicutes/Bacteroidetes ratios and lower Proteobacteria percentages than GGMOS_Ac.
32551624	2	15	theme	ileal	492:496	arg1	SIEM					513:516	SIEM	513:516	SIEM	513:516	The effects on the microbiota and their activity were also compared to a standard ileal efflux medium (SIEM).
32551624	2	15	theme	ileal	492:496	arg1	medium					505:510	a standard ileal efflux medium	481:510	a standard ileal efflux medium (SIEM)	481:517	The effects on the microbiota and their activity were also compared to a standard ileal efflux medium (SIEM).
32551624	7	16	theme	suitable	1140:1147	arg1	substrates					1149:1158	more suitable substrates	1135:1158	more suitable substrates for the elderly	1135:1174	This suggests that GGMOS would be more suitable substrates for the elderly, even though GGMOS_Ac promoted positive effects that support the interest of further research using these oligosaccharides as "carriers" of desired substituents.
32551624	4	17	theme	lower	789:793	arg1	percentages					810:820	lower Proteobacteria percentages	789:820	lower Proteobacteria percentages	789:820	Although comparable Actinobacteria abundances were observed with both substrates, GGMOS fermentation led to higher Firmicutes/Bacteroidetes ratios and lower Proteobacteria percentages than GGMOS_Ac.
32551624	5	18	theme	genus	904:908	arg1	percentages					878:888	the percentages	874:888	the percentages of beneficial genus such as Blautia, Faecalibacterium, Coprococcus, or Bifidobacterium	874:975	No differences were found concerning the percentages of beneficial genus such as Blautia, Faecalibacterium, Coprococcus, or Bifidobacterium.
32551624	7	19	theme	research	1261:1268	arg1	interest					1241:1248	the interest	1237:1248	the interest of further research using these oligosaccharides as "carriers" of desired substituents	1237:1335	This suggests that GGMOS would be more suitable substrates for the elderly, even though GGMOS_Ac promoted positive effects that support the interest of further research using these oligosaccharides as "carriers" of desired substituents.
32551624	3	20	theme	higher	538:543	arg1	productions					558:568	higher organic acid productions	538:568	higher organic acid productions	538:568	GGMOS resulted in higher organic acid productions and higher short-chain fatty acids/total organic acid molar ratios.
32551624	2	21	theme	microbiota	429:438	arg1	activity					450:457	the microbiota and their activity	425:457	activity	450:457	The effects on the microbiota and their activity were also compared to a standard ileal efflux medium (SIEM).
32551624	5	22	theme	beneficial	893:902	arg1	Faecalibacterium					927:942	Faecalibacterium	927:942	Faecalibacterium	927:942	No differences were found concerning the percentages of beneficial genus such as Blautia, Faecalibacterium, Coprococcus, or Bifidobacterium.
32551624	5	22	theme	beneficial	893:902	arg1	genus					904:908	beneficial genus	893:908	beneficial genus such as Blautia, Faecalibacterium, Coprococcus, or Bifidobacterium	893:975	No differences were found concerning the percentages of beneficial genus such as Blautia, Faecalibacterium, Coprococcus, or Bifidobacterium.
32551624	5	22	theme	beneficial	893:902	arg1	Blautia					918:924	Blautia	918:924	Blautia	918:924	No differences were found concerning the percentages of beneficial genus such as Blautia, Faecalibacterium, Coprococcus, or Bifidobacterium.
32551624	5	22	theme	beneficial	893:902	arg1	Coprococcus					945:955	Coprococcus	945:955	Coprococcus	945:955	No differences were found concerning the percentages of beneficial genus such as Blautia, Faecalibacterium, Coprococcus, or Bifidobacterium.
32551624	5	22	theme	beneficial	893:902	arg1	Bifidobacterium					961:975	Bifidobacterium	961:975	Bifidobacterium	961:975	No differences were found concerning the percentages of beneficial genus such as Blautia, Faecalibacterium, Coprococcus, or Bifidobacterium.
32551624	3	23	theme	organic	545:551	arg1	productions					558:568	higher organic acid productions	538:568	higher organic acid productions	538:568	GGMOS resulted in higher organic acid productions and higher short-chain fatty acids/total organic acid molar ratios.
32551624	3	24	dep	higher	574:579	arg1	acid					619:622	short-chain fatty acids/total organic acid	581:622	short-chain fatty acids/total organic acid	581:622	GGMOS resulted in higher organic acid productions and higher short-chain fatty acids/total organic acid molar ratios.
32551624	4	25	theme	Firmicutes/Bacteroidetes	753:776	arg1	ratios					778:783	higher Firmicutes/Bacteroidetes ratios	746:783	higher Firmicutes/Bacteroidetes ratios	746:783	Although comparable Actinobacteria abundances were observed with both substrates, GGMOS fermentation led to higher Firmicutes/Bacteroidetes ratios and lower Proteobacteria percentages than GGMOS_Ac.
32551624	0	26	theme	High-	13:17	arg1	Galactoglucomannooligosaccharides					38:70	High- and Low-Acetylated Galactoglucomannooligosaccharides	13:70	High- and Low-Acetylated Galactoglucomannooligosaccharides	13:70	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition and Their Activity: A Comparison Using the In Vitro Model of the Human Colon TIM-2.
32551624	1	27	theme	fecal	375:379	arg1	microbiota					381:390	fecal microbiota	375:390	fecal microbiota from the elderly	375:407	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	4	28	theme	higher	746:751	arg1	ratios					778:783	higher Firmicutes/Bacteroidetes ratios	746:783	higher Firmicutes/Bacteroidetes ratios	746:783	Although comparable Actinobacteria abundances were observed with both substrates, GGMOS fermentation led to higher Firmicutes/Bacteroidetes ratios and lower Proteobacteria percentages than GGMOS_Ac.
32551624	1	29	theme	High-	200:204	arg1	GGMOS_Ac					260:267	GGMOS_Ac	260:267	GGMOS_Ac	260:267	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	1	29	theme	High-	200:204	arg1	galactoglucomannooligosaccharides					225:257	High- and low-acetylated galactoglucomannooligosaccharides	200:257	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively)	200:292	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	1	29	theme	High-	200:204	arg1	substrates					310:319	substrates	310:319	substrates	310:319	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	1	29	theme	High-	200:204	arg1	GGMOS					273:277	GGMOS	273:277	GGMOS	273:277	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	0	30	theme	Galactoglucomannooligosaccharides	38:70	arg1	Potential					0:8	Potential	0:8	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition	0:114	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition and Their Activity: A Comparison Using the In Vitro Model of the Human Colon TIM-2.
32551624	0	30	theme	Galactoglucomannooligosaccharides	38:70	arg1	Activity					126:133	Their Activity	120:133	Their Activity	120:133	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition and Their Activity: A Comparison Using the In Vitro Model of the Human Colon TIM-2.
32551624	6	31	theme	bacterial	994:1002	arg1	diversities					1004:1014	higher bacterial diversities	987:1014	higher bacterial diversities	987:1014	However, higher bacterial diversities and numbers of genera such as Oscillospira and Lachnospira were found with GGMOS_Ac.
32551624	6	31	theme	bacterial	994:1002	arg1	Lachnospira					1063:1073	Lachnospira	1063:1073	Lachnospira	1063:1073	However, higher bacterial diversities and numbers of genera such as Oscillospira and Lachnospira were found with GGMOS_Ac.
32551624	6	31	theme	bacterial	994:1002	arg1	Oscillospira					1046:1057	Oscillospira	1046:1057	Oscillospira	1046:1057	However, higher bacterial diversities and numbers of genera such as Oscillospira and Lachnospira were found with GGMOS_Ac.
32551624	4	32	theme	Actinobacteria	658:671	arg1	abundances					673:682	comparable Actinobacteria abundances	647:682	comparable Actinobacteria abundances	647:682	Although comparable Actinobacteria abundances were observed with both substrates, GGMOS fermentation led to higher Firmicutes/Bacteroidetes ratios and lower Proteobacteria percentages than GGMOS_Ac.
32551624	0	33	theme	Low-Acetylated	23:36	arg1	Galactoglucomannooligosaccharides					38:70	High- and Low-Acetylated Galactoglucomannooligosaccharides	13:70	High- and Low-Acetylated Galactoglucomannooligosaccharides	13:70	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition and Their Activity: A Comparison Using the In Vitro Model of the Human Colon TIM-2.
32551624	6	34	theme	higher	987:992	arg1	diversities					1004:1014	higher bacterial diversities	987:1014	higher bacterial diversities	987:1014	However, higher bacterial diversities and numbers of genera such as Oscillospira and Lachnospira were found with GGMOS_Ac.
32551624	6	34	theme	higher	987:992	arg1	Lachnospira					1063:1073	Lachnospira	1063:1073	Lachnospira	1063:1073	However, higher bacterial diversities and numbers of genera such as Oscillospira and Lachnospira were found with GGMOS_Ac.
32551624	6	34	theme	higher	987:992	arg1	Oscillospira					1046:1057	Oscillospira	1046:1057	Oscillospira	1046:1057	However, higher bacterial diversities and numbers of genera such as Oscillospira and Lachnospira were found with GGMOS_Ac.
32551624	1	35	dep	galactoglucomannooligosaccharides	225:257	arg1	GGMOS_Ac					260:267	GGMOS_Ac	260:267	GGMOS_Ac	260:267	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	1	35	dep	galactoglucomannooligosaccharides	225:257	arg1	galactoglucomannooligosaccharides					225:257	High- and low-acetylated galactoglucomannooligosaccharides	200:257	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively)	200:292	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	1	35	dep	galactoglucomannooligosaccharides	225:257	arg1	GGMOS					273:277	GGMOS	273:277	GGMOS	273:277	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	3	36	theme	higher	574:579	arg1	ratios					630:635	higher short-chain fatty acids/total organic acid molar ratios	574:635	higher short-chain fatty acids/total organic acid molar ratios	574:635	GGMOS resulted in higher organic acid productions and higher short-chain fatty acids/total organic acid molar ratios.
32551624	1	37	theme	low-acetylated	210:223	arg1	GGMOS_Ac					260:267	GGMOS_Ac	260:267	GGMOS_Ac	260:267	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	1	37	theme	low-acetylated	210:223	arg1	galactoglucomannooligosaccharides					225:257	High- and low-acetylated galactoglucomannooligosaccharides	200:257	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively)	200:292	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	1	37	theme	low-acetylated	210:223	arg1	substrates					310:319	substrates	310:319	substrates	310:319	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	1	37	theme	low-acetylated	210:223	arg1	GGMOS					273:277	GGMOS	273:277	GGMOS	273:277	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	3	38	theme	molar	624:628	arg1	ratios					630:635	higher short-chain fatty acids/total organic acid molar ratios	574:635	higher short-chain fatty acids/total organic acid molar ratios	574:635	GGMOS resulted in higher organic acid productions and higher short-chain fatty acids/total organic acid molar ratios.
32551624	3	39	theme	acid	553:556	arg1	productions					558:568	higher organic acid productions	538:568	higher organic acid productions	538:568	GGMOS resulted in higher organic acid productions and higher short-chain fatty acids/total organic acid molar ratios.
32551624	7	40	theme	desired	1316:1322	arg1	substituents					1324:1335	desired substituents	1316:1335	desired substituents	1316:1335	This suggests that GGMOS would be more suitable substrates for the elderly, even though GGMOS_Ac promoted positive effects that support the interest of further research using these oligosaccharides as "carriers" of desired substituents.
32551624	2	41	theme	their	444:448	arg1	activity					450:457	the microbiota and their activity	425:457	activity	450:457	The effects on the microbiota and their activity were also compared to a standard ileal efflux medium (SIEM).
32551624	1	42	theme	TIM-2	328:332	arg1	model					349:353	the TIM-2 in vitro colon model	324:353	the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly	324:407	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	0	43	theme	In	159:160	arg1	Model					168:172	the In Vitro Model	155:172	the In Vitro Model of the Human Colon TIM-2	155:197	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition and Their Activity: A Comparison Using the In Vitro Model of the Human Colon TIM-2.
32551624	7	44	theme	substituents	1324:1335	arg1	"					1311:1311	"carriers"	1302:1311	"carriers" of desired substituents	1302:1335	This suggests that GGMOS would be more suitable substrates for the elderly, even though GGMOS_Ac promoted positive effects that support the interest of further research using these oligosaccharides as "carriers" of desired substituents.
32551624	1	45	from	elderly	401:407	arg1	microbiota					381:390	fecal microbiota	375:390	fecal microbiota from the elderly	375:407	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	1	46	theme	in	334:335	arg1	model					349:353	the TIM-2 in vitro colon model	324:353	the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly	324:407	High- and low-acetylated galactoglucomannooligosaccharides (GGMOS_Ac and GGMOS, respectively) were assayed as substrates in the TIM-2 in vitro colon model using, as inoculum, fecal microbiota from the elderly.
32551624	3	47	theme	acids/total	599:609	arg1	acid					619:622	short-chain fatty acids/total organic acid	581:622	short-chain fatty acids/total organic acid	581:622	GGMOS resulted in higher organic acid productions and higher short-chain fatty acids/total organic acid molar ratios.
32551624	3	48	theme	organic	611:617	arg1	acid					619:622	short-chain fatty acids/total organic acid	581:622	short-chain fatty acids/total organic acid	581:622	GGMOS resulted in higher organic acid productions and higher short-chain fatty acids/total organic acid molar ratios.
32551624	0	49	dep	In	159:160	arg1	Vitro					162:166	Vitro	162:166	Vitro	162:166	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition and Their Activity: A Comparison Using the In Vitro Model of the Human Colon TIM-2.
32551624	2	50	theme	standard	483:490	arg1	SIEM					513:516	SIEM	513:516	SIEM	513:516	The effects on the microbiota and their activity were also compared to a standard ileal efflux medium (SIEM).
32551624	2	50	theme	standard	483:490	arg1	medium					505:510	a standard ileal efflux medium	481:510	a standard ileal efflux medium (SIEM)	481:517	The effects on the microbiota and their activity were also compared to a standard ileal efflux medium (SIEM).
32551624	3	51	theme	short-chain	581:591	arg1	acid					619:622	short-chain fatty acids/total organic acid	581:622	short-chain fatty acids/total organic acid	581:622	GGMOS resulted in higher organic acid productions and higher short-chain fatty acids/total organic acid molar ratios.
32551624	0	52	dep	Potential	0:8	arg1	Comparison					138:147	A Comparison	136:147	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition and Their Activity: A Comparison Using the In Vitro Model of the Human Colon TIM-2.	0:198	Potential of High- and Low-Acetylated Galactoglucomannooligosaccharides as Modulators of the Microbiota Composition and Their Activity: A Comparison Using the In Vitro Model of the Human Colon TIM-2.
32551624	2	53	from	effects	414:420	arg1	activity					450:457	the microbiota and their activity	425:457	activity	450:457	The effects on the microbiota and their activity were also compared to a standard ileal efflux medium (SIEM).
32551624	7	54	theme	carriers	1303:1310	arg1	"					1311:1311	"carriers"	1302:1311	"carriers" of desired substituents	1302:1335	This suggests that GGMOS would be more suitable substrates for the elderly, even though GGMOS_Ac promoted positive effects that support the interest of further research using these oligosaccharides as "carriers" of desired substituents.
34973780	2	0	theme	volume	427:432	arg1	ratios					434:439	volume ratios	427:439	volume ratios	427:439	Zinc oxide nanoparticle has been extensively studied for antimicrobial, antifungal and antifouling properties due to high surface to volume ratios and distinctive chemical as well as physical properties.
34973780	5	1	theme	cell	979:982	arg1	%					998:998	cell viability 93.6%	979:998	cell viability 93.6%	979:998	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	4	2	theme	in	586:587	arg1	NPs					645:647	in situ nanostructured and polysaccharide encapsulated ZnO NPs	586:647	in situ nanostructured and polysaccharide encapsulated ZnO NPs	586:647	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	6	3	from	role	1096:1099	arg1	nanotoxicity					1138:1149	their nanotoxicity	1132:1149	their nanotoxicity	1132:1149	This study brings significant insights regarding the role of ZnO NPs surface coatings on their nanotoxicity and antiviral action and could potentially guide to the development of better antiviral drug.
34973780	6	3	from	role	1096:1099	arg1	action					1165:1170	antiviral action	1155:1170	antiviral action	1155:1170	This study brings significant insights regarding the role of ZnO NPs surface coatings on their nanotoxicity and antiviral action and could potentially guide to the development of better antiviral drug.
34973780	4	4	theme	antiviral	676:684	arg1	potency					686:692	antiviral potency	676:692	antiviral potency	676:692	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	0	5	theme	human	110:114	arg1	cytomegalovirus					116:130	human cytomegalovirus	110:130	human cytomegalovirus	110:130	Chitosan/benzyloxy-benzaldehyde modified ZnO nano template having optimized and distinct antiviral potency to human cytomegalovirus.
34973780	6	6	theme	drug	1239:1242	arg1	development					1207:1217	the development	1203:1217	the development of better antiviral drug	1203:1242	This study brings significant insights regarding the role of ZnO NPs surface coatings on their nanotoxicity and antiviral action and could potentially guide to the development of better antiviral drug.
34973780	4	7	theme	locking	831:837	arg1	mechanism					839:847	perfect locking mechanism	823:847	perfect locking mechanism	823:847	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	4	8	theme	3D	790:791	arg1	networks					793:800	interspatial 3D networks	777:800	interspatial 3D networks of hydrogels	777:813	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	6	9	theme	ZnO	1104:1106	arg1	coatings					1120:1127	ZnO NPs surface coatings	1104:1127	ZnO NPs surface coatings	1104:1127	This study brings significant insights regarding the role of ZnO NPs surface coatings on their nanotoxicity and antiviral action and could potentially guide to the development of better antiviral drug.
34973780	5	10	theme	400 μg mL-1	1016:1026	arg1	concentration					1028:1040	400 μg mL-1 concentration	1016:1040	400 μg mL-1 concentration	1016:1040	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	6	11	theme	coatings	1120:1127	arg1	role					1096:1099	the role	1092:1099	the role of ZnO NPs surface coatings on their nanotoxicity and antiviral action	1092:1170	This study brings significant insights regarding the role of ZnO NPs surface coatings on their nanotoxicity and antiviral action and could potentially guide to the development of better antiviral drug.
34973780	1	12	theme	ample	214:218	arg1	attention					220:228	ample attention	214:228	ample attention	214:228	Utilization of biomolecules encapsulated nano particles is currently originating ample attention to generate unconventional nanomedicines in antiviral research.
34973780	5	13	theme	@	872:872	arg1	composites					858:867	The two composites	850:867	The two composites ChH@ZnO and ChB@ZnO	850:887	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	5	13	theme	@	872:872	arg1	ZnO					873:875	ChH@ZnO	869:875	ChH@ZnO	869:875	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	6	14	theme	better	1222:1227	arg1	drug					1239:1242	better antiviral drug	1222:1242	better antiviral drug	1222:1242	This study brings significant insights regarding the role of ZnO NPs surface coatings on their nanotoxicity and antiviral action and could potentially guide to the development of better antiviral drug.
34973780	3	15	theme	minute	518:523	arg1	information					525:535	still minute information	512:535	still minute information	512:535	Nevertheless, still minute information is available on their response on viruses.
34973780	3	16	from	response	559:566	arg1	viruses					571:577	viruses	571:577	viruses	571:577	Nevertheless, still minute information is available on their response on viruses.
34973780	4	17	theme	hydrogels	805:813	arg1	networks					793:800	interspatial 3D networks	777:800	interspatial 3D networks of hydrogels	777:813	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	2	18	theme	chemical	457:464	arg1	properties					486:495	distinctive chemical as well as physical properties	445:495	distinctive chemical as well as physical properties	445:495	Zinc oxide nanoparticle has been extensively studied for antimicrobial, antifungal and antifouling properties due to high surface to volume ratios and distinctive chemical as well as physical properties.
34973780	4	19	theme	ZnO	641:643	arg1	NPs					645:647	in situ nanostructured and polysaccharide encapsulated ZnO NPs	586:647	in situ nanostructured and polysaccharide encapsulated ZnO NPs	586:647	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	5	20	dep	composites	858:867	arg1	ZnO					885:887	ChB@ZnO	881:887	ChB@ZnO	881:887	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	5	20	dep	composites	858:867	arg1	composites					858:867	The two composites	850:867	The two composites ChH@ZnO and ChB@ZnO	850:887	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	5	20	dep	composites	858:867	arg1	ZnO					873:875	ChH@ZnO	869:875	ChH@ZnO	869:875	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	2	21	theme	antifouling	381:391	arg1	properties					393:402	antifouling properties	381:402	antifouling properties	381:402	Zinc oxide nanoparticle has been extensively studied for antimicrobial, antifungal and antifouling properties due to high surface to volume ratios and distinctive chemical as well as physical properties.
34973780	2	22	theme	distinctive	445:455	arg1	properties					486:495	distinctive chemical as well as physical properties	445:495	distinctive chemical as well as physical properties	445:495	Zinc oxide nanoparticle has been extensively studied for antimicrobial, antifungal and antifouling properties due to high surface to volume ratios and distinctive chemical as well as physical properties.
34973780	0	23	theme	nano	45:48	arg1	template					50:57	ZnO nano template	41:57	ZnO nano template	41:57	Chitosan/benzyloxy-benzaldehyde modified ZnO nano template having optimized and distinct antiviral potency to human cytomegalovirus.
34973780	4	24	theme	encapsulated	628:639	arg1	NPs					645:647	in situ nanostructured and polysaccharide encapsulated ZnO NPs	586:647	in situ nanostructured and polysaccharide encapsulated ZnO NPs	586:647	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	4	25	theme	perfect	823:829	arg1	mechanism					839:847	perfect locking mechanism	823:847	perfect locking mechanism	823:847	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	1	26	theme	unconventional	242:255	arg1	nanomedicines					257:269	unconventional nanomedicines	242:269	unconventional nanomedicines in antiviral research	242:291	Utilization of biomolecules encapsulated nano particles is currently originating ample attention to generate unconventional nanomedicines in antiviral research.
34973780	0	27	theme	ZnO	41:43	arg1	template					50:57	ZnO nano template	41:57	ZnO nano template	41:57	Chitosan/benzyloxy-benzaldehyde modified ZnO nano template having optimized and distinct antiviral potency to human cytomegalovirus.
34973780	6	28	theme	antiviral	1229:1237	arg1	drug					1239:1242	better antiviral drug	1222:1242	better antiviral drug	1222:1242	This study brings significant insights regarding the role of ZnO NPs surface coatings on their nanotoxicity and antiviral action and could potentially guide to the development of better antiviral drug.
34973780	6	29	theme	significant	1061:1071	arg1	insights					1073:1080	significant insights	1061:1080	significant insights regarding the role of ZnO NPs surface coatings on their nanotoxicity and antiviral action	1061:1170	This study brings significant insights regarding the role of ZnO NPs surface coatings on their nanotoxicity and antiviral action and could potentially guide to the development of better antiviral drug.
34973780	5	30	theme	ChB	881:883	arg1	ZnO					885:887	ChB@ZnO	881:887	ChB@ZnO	881:887	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	5	30	theme	ChB	881:883	arg1	composites					858:867	The two composites	850:867	The two composites ChH@ZnO and ChB@ZnO	850:887	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	2	31	theme	high	411:414	arg1	surface					416:422	high surface	411:422	high surface to volume ratios and distinctive chemical as well as physical properties	411:495	Zinc oxide nanoparticle has been extensively studied for antimicrobial, antifungal and antifouling properties due to high surface to volume ratios and distinctive chemical as well as physical properties.
34973780	4	32	theme	~	727:727	arg1	%					731:731	%viability ~ 90%	716:731	%viability ~ 90%	716:731	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	4	32	theme	~	727:727	arg1	cytotoxicity					702:713	low cytotoxicity	698:713	low cytotoxicity (%viability ~ 90%)	698:732	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	2	33	theme	oxide	299:303	arg1	nanoparticle					305:316	Zinc oxide nanoparticle	294:316	Zinc oxide nanoparticle	294:316	Zinc oxide nanoparticle has been extensively studied for antimicrobial, antifungal and antifouling properties due to high surface to volume ratios and distinctive chemical as well as physical properties.
34973780	5	34	theme	Human	943:947	arg1	HCMV					966:969	HCMV	966:969	HCMV	966:969	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	5	34	theme	Human	943:947	arg1	cytomegalovirus					949:963	Human cytomegalovirus	943:963	Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration	943:1040	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	2	35	theme	physical	477:484	arg1	properties					486:495	distinctive chemical as well as physical properties	445:495	distinctive chemical as well as physical properties	445:495	Zinc oxide nanoparticle has been extensively studied for antimicrobial, antifungal and antifouling properties due to high surface to volume ratios and distinctive chemical as well as physical properties.
34973780	5	36	theme	antiviral	917:925	arg1	activity					927:934	exceedingly effective antiviral activity	895:934	exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration	895:1040	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	4	37	theme	nanostructured	594:607	arg1	NPs					645:647	in situ nanostructured and polysaccharide encapsulated ZnO NPs	586:647	in situ nanostructured and polysaccharide encapsulated ZnO NPs	586:647	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	2	38	theme	Zinc	294:297	arg1	nanoparticle					305:316	Zinc oxide nanoparticle	294:316	Zinc oxide nanoparticle	294:316	Zinc oxide nanoparticle has been extensively studied for antimicrobial, antifungal and antifouling properties due to high surface to volume ratios and distinctive chemical as well as physical properties.
34973780	5	39	theme	effective	907:915	arg1	activity					927:934	exceedingly effective antiviral activity	895:934	exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration	895:1040	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	1	40	theme	antiviral	274:282	arg1	research					284:291	antiviral research	274:291	antiviral research	274:291	Utilization of biomolecules encapsulated nano particles is currently originating ample attention to generate unconventional nanomedicines in antiviral research.
34973780	5	41	theme	ChH	869:871	arg1	composites					858:867	The two composites	850:867	The two composites ChH@ZnO and ChB@ZnO	850:887	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	5	41	theme	ChH	869:871	arg1	ZnO					873:875	ChH@ZnO	869:875	ChH@ZnO	869:875	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	4	42	dep	in	586:587	arg1	situ					589:592	situ	589:592	situ	589:592	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	4	43	theme	interspatial	777:788	arg1	networks					793:800	interspatial 3D networks	777:800	interspatial 3D networks of hydrogels	777:813	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	0	44	theme	optimized	66:74	arg1	potency					99:105	optimized and distinct antiviral potency	66:105	optimized and distinct antiviral potency	66:105	Chitosan/benzyloxy-benzaldehyde modified ZnO nano template having optimized and distinct antiviral potency to human cytomegalovirus.
34973780	4	45	theme	polysaccharide	613:626	arg1	NPs					645:647	in situ nanostructured and polysaccharide encapsulated ZnO NPs	586:647	in situ nanostructured and polysaccharide encapsulated ZnO NPs	586:647	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	6	46	theme	surface	1112:1118	arg1	coatings					1120:1127	ZnO NPs surface coatings	1104:1127	ZnO NPs surface coatings	1104:1127	This study brings significant insights regarding the role of ZnO NPs surface coatings on their nanotoxicity and antiviral action and could potentially guide to the development of better antiviral drug.
34973780	1	47	theme	biomolecules	148:159	arg1	particles					179:187	biomolecules encapsulated nano particles	148:187	biomolecules encapsulated nano particles	148:187	Utilization of biomolecules encapsulated nano particles is currently originating ample attention to generate unconventional nanomedicines in antiviral research.
34973780	1	48	from	nanomedicines	257:269	arg1	research					284:291	antiviral research	274:291	antiviral research	274:291	Utilization of biomolecules encapsulated nano particles is currently originating ample attention to generate unconventional nanomedicines in antiviral research.
34973780	1	49	theme	encapsulated	161:172	arg1	particles					179:187	biomolecules encapsulated nano particles	148:187	biomolecules encapsulated nano particles	148:187	Utilization of biomolecules encapsulated nano particles is currently originating ample attention to generate unconventional nanomedicines in antiviral research.
34973780	5	50	contain	having	972:977	arg1	HCMV					966:969	HCMV	966:969	HCMV	966:969	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	5	50	contain	having	972:977	arg2	%					998:998	cell viability 93.6%	979:998	cell viability 93.6%	979:998	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	5	50	contain	having	972:977	arg1	cytomegalovirus					949:963	Human cytomegalovirus	943:963	Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration	943:1040	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	5	50	contain	having	972:977	arg2	%					1008:1008	92.4%	1004:1008	92.4% up to 400 μg mL-1 concentration	1004:1040	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	6	51	theme	NPs	1108:1110	arg1	coatings					1120:1127	ZnO NPs surface coatings	1104:1127	ZnO NPs surface coatings	1104:1127	This study brings significant insights regarding the role of ZnO NPs surface coatings on their nanotoxicity and antiviral action and could potentially guide to the development of better antiviral drug.
34973780	1	52	theme	nano	174:177	arg1	particles					179:187	biomolecules encapsulated nano particles	148:187	biomolecules encapsulated nano particles	148:187	Utilization of biomolecules encapsulated nano particles is currently originating ample attention to generate unconventional nanomedicines in antiviral research.
34973780	5	53	theme	viability	984:992	arg1	%					998:998	cell viability 93.6%	979:998	cell viability 93.6%	979:998	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	0	54	theme	antiviral	89:97	arg1	potency					99:105	optimized and distinct antiviral potency	66:105	optimized and distinct antiviral potency	66:105	Chitosan/benzyloxy-benzaldehyde modified ZnO nano template having optimized and distinct antiviral potency to human cytomegalovirus.
34973780	4	55	theme	viability	717:725	arg1	%					731:731	%viability ~ 90%	716:731	%viability ~ 90%	716:731	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	4	55	theme	viability	717:725	arg1	cytotoxicity					702:713	low cytotoxicity	698:713	low cytotoxicity (%viability ~ 90%)	698:732	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	4	56	theme	%	716:716	arg1	%					731:731	%viability ~ 90%	716:731	%viability ~ 90%	716:731	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	4	56	theme	%	716:716	arg1	cytotoxicity					702:713	low cytotoxicity	698:713	low cytotoxicity (%viability ~ 90%)	698:732	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	1	57	theme	particles	179:187	arg1	Utilization					133:143	Utilization	133:143	Utilization of biomolecules encapsulated nano particles	133:187	Utilization of biomolecules encapsulated nano particles is currently originating ample attention to generate unconventional nanomedicines in antiviral research.
34973780	0	58	theme	distinct	80:87	arg1	potency					99:105	optimized and distinct antiviral potency	66:105	optimized and distinct antiviral potency	66:105	Chitosan/benzyloxy-benzaldehyde modified ZnO nano template having optimized and distinct antiviral potency to human cytomegalovirus.
34973780	5	59	theme	@	884:884	arg1	ZnO					885:887	ChB@ZnO	881:887	ChB@ZnO	881:887	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	5	59	theme	@	884:884	arg1	composites					858:867	The two composites	850:867	The two composites ChH@ZnO and ChB@ZnO	850:887	The two composites ChH@ZnO and ChB@ZnO shows exceedingly effective antiviral activity toward Human cytomegalovirus (HCMV) having cell viability 93.6% and 92.4% up to 400 μg mL-1 concentration.
34973780	6	60	theme	antiviral	1155:1163	arg1	action					1165:1170	antiviral action	1155:1170	antiviral action	1155:1170	This study brings significant insights regarding the role of ZnO NPs surface coatings on their nanotoxicity and antiviral action and could potentially guide to the development of better antiviral drug.
34973780	4	61	theme	low	698:700	arg1	%					731:731	%viability ~ 90%	716:731	%viability ~ 90%	716:731	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
34973780	4	61	theme	low	698:700	arg1	cytotoxicity					702:713	low cytotoxicity	698:713	low cytotoxicity (%viability ~ 90%)	698:732	Here, in situ nanostructured and polysaccharide encapsulated ZnO NPs are fabricated with having antiviral potency and low cytotoxicity (%viability ~ 90%) by simply controlling the formation within interspatial 3D networks of hydrogels through perfect locking mechanism.
33340625	4	0	dep	methods	542:548	arg1	methods					542:548	Two different methods	528:548	Two different methods - slurry evaporation and spray drying -	528:588	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	4	0	dep	methods	542:548	arg1	evaporation					559:569	slurry evaporation	552:569	slurry evaporation	552:569	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	4	0	dep	methods	542:548	arg1	drying					581:586	spray drying	575:586	spray drying	575:586	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	4	1	theme	resultant	711:719	arg1	products					721:728	the resultant products	707:728	the resultant products	707:728	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	5	2	theme	beneficial	789:798	arg1	effects					800:806	the beneficial effects	785:806	the beneficial effects of being combined with GPs	785:833	Several of the natural compounds showed the beneficial effects of being combined with GPs.
33340625	6	3	theme	rotary	923:928	arg1	evaporator					930:939	a rotary evaporator	921:939	a rotary evaporator	921:939	The materials prepared by spray drying showed greater activity than those made using a rotary evaporator.
33340625	7	4	dep	factors	1152:1158	arg1	NF-κB/AP-1					1160:1169	NF-κB/AP-1	1160:1169	NF-κB/AP-1	1160:1169	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	7	4	dep	factors	1152:1158	arg1	secretion					1179:1187	the secretion	1175:1187	the secretion of the pro-inflammatory cytokine TNF-α	1175:1226	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	7	4	dep	factors	1152:1158	arg1	factors					1152:1158	transcription factors	1138:1158	transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α	1138:1226	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	7	5	theme	factors	1152:1158	arg1	activity					1126:1133	the activity	1122:1133	the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α	1122:1226	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	7	6	theme	greater	995:1001	arg1	potential					1021:1029	greater anti-inflammatory potential	995:1029	greater anti-inflammatory potential	995:1029	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	7	7	theme	yeast	978:982	arg1	GPs					984:986	yeast GPs	978:986	yeast GPs	978:986	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	7	8	theme	TNF-α	1222:1226	arg1	NF-κB/AP-1					1160:1169	NF-κB/AP-1	1160:1169	NF-κB/AP-1	1160:1169	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	7	8	theme	TNF-α	1222:1226	arg1	secretion					1179:1187	the secretion	1175:1187	the secretion of the pro-inflammatory cytokine TNF-α	1175:1226	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	7	8	theme	TNF-α	1222:1226	arg1	factors					1152:1158	transcription factors	1138:1158	transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α	1138:1226	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	4	9	theme	GPs + bioactive	623:637	arg1	composites					611:620	composites	611:620	composites (GPs + bioactive compound)	611:647	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	4	9	theme	GPs + bioactive	623:637	arg1	compound					639:646	GPs + bioactive compound	623:646	GPs + bioactive compound	623:646	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	4	10	theme	anti-inflammatory	657:673	arg1	properties					693:702	the anti-inflammatory and antioxidative properties	653:702	the anti-inflammatory and antioxidative properties of the resultant products	653:728	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	5	11	theme	natural	760:766	arg1	compounds					768:776	the natural compounds	756:776	the natural compounds	756:776	Several of the natural compounds showed the beneficial effects of being combined with GPs.
33340625	0	12	theme	yeast	55:59	arg1	particles					68:76	yeast glucan particles	55:76	yeast glucan particles	55:76	Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro.
33340625	0	13	theme	natural	14:20	arg1	compounds					40:48	natural anti-inflammatory compounds	14:48	natural anti-inflammatory compounds	14:48	Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro.
33340625	4	14	theme	antioxidative	679:691	arg1	properties					693:702	the anti-inflammatory and antioxidative properties	653:702	the anti-inflammatory and antioxidative properties of the resultant products	653:728	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	3	15	dep	gallate	412:418	arg1	-					392:392	-	392:392	-	392:392	This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro.
33340625	7	16	theme	Natural	942:948	arg1	compounds					950:958	Natural compounds	942:958	Natural compounds incorporated into yeast GPs	942:986	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	3	17	theme	ellagic	377:383	arg1	artemisinin					364:374	artemisinin	364:374	artemisinin	364:374	This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro.
33340625	3	17	theme	ellagic	377:383	arg1	trans-resveratrol					433:449	trans-resveratrol	433:449	trans-resveratrol	433:449	This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro.
33340625	3	17	theme	ellagic	377:383	arg1	acid					385:388	ellagic acid	377:388	ellagic acid	377:388	This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro.
33340625	3	17	theme	ellagic	377:383	arg1	morusin					421:427	morusin	421:427	morusin	421:427	This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro.
33340625	3	17	theme	ellagic	377:383	arg1	gallate					412:418	-epigallocatechin gallate	394:418	-epigallocatechin gallate	394:418	This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro.
33340625	4	18	theme	slurry	552:557	arg1	methods					542:548	Two different methods	528:548	Two different methods - slurry evaporation and spray drying -	528:588	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	4	18	theme	slurry	552:557	arg1	evaporation					559:569	slurry evaporation	552:569	slurry evaporation	552:569	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	1	19	theme	Yeast	116:120	arg1	GPs					140:142	GPs	140:142	GPs	140:142	Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs.
33340625	1	19	theme	Yeast	116:120	arg1	particles					129:137	Yeast glucan particles	116:137	Yeast glucan particles (GPs)	116:143	Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs.
33340625	1	19	theme	Yeast	116:120	arg1	agents					159:164	promising agents	149:164	promising agents for the delivery of biologically active compounds as drugs	149:223	Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs.
33340625	1	20	theme	active	199:204	arg1	compounds					206:214	biologically active compounds	186:214	biologically active compounds as drugs	186:223	Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs.
33340625	0	21	theme	anti-inflammatory	22:38	arg1	compounds					40:48	natural anti-inflammatory compounds	14:48	natural anti-inflammatory compounds	14:48	Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro.
33340625	4	22	theme	spray	575:579	arg1	methods					542:548	Two different methods	528:548	Two different methods - slurry evaporation and spray drying -	528:588	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	4	22	theme	spray	575:579	arg1	drying					581:586	spray drying	575:586	spray drying	575:586	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	1	23	theme	glucan	122:127	arg1	GPs					140:142	GPs	140:142	GPs	140:142	Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs.
33340625	1	23	theme	glucan	122:127	arg1	particles					129:137	Yeast glucan particles	116:137	Yeast glucan particles (GPs)	116:143	Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs.
33340625	1	23	theme	glucan	122:127	arg1	agents					159:164	promising agents	149:164	promising agents for the delivery of biologically active compounds as drugs	149:223	Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs.
33340625	1	24	theme	compounds	206:214	arg1	delivery					174:181	the delivery	170:181	the delivery of biologically active compounds as drugs	170:223	Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs.
33340625	3	25	theme	-epigallocatechin	394:410	arg1	acid					385:388	ellagic acid	377:388	ellagic acid	377:388	This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro.
33340625	3	25	theme	-epigallocatechin	394:410	arg1	gallate					412:418	-epigallocatechin gallate	394:418	-epigallocatechin gallate	394:418	This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro.
33340625	4	26	theme	products	721:728	arg1	properties					693:702	the anti-inflammatory and antioxidative properties	653:702	the anti-inflammatory and antioxidative properties of the resultant products	653:728	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	6	27	theme	greater	882:888	arg1	activity					890:897	greater activity	882:897	greater activity	882:897	The materials prepared by spray drying showed greater activity than those made using a rotary evaporator.
33340625	7	28	theme	pro-inflammatory	1196:1211	arg1	cytokine					1213:1220	the pro-inflammatory cytokine	1192:1220	the pro-inflammatory cytokine TNF-α	1192:1226	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	4	29	theme	different	532:540	arg1	methods					542:548	Two different methods	528:548	Two different methods - slurry evaporation and spray drying -	528:588	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	4	29	theme	different	532:540	arg1	evaporation					559:569	slurry evaporation	552:569	slurry evaporation	552:569	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	4	29	theme	different	532:540	arg1	drying					581:586	spray drying	575:586	spray drying	575:586	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	7	30	theme	cytokine	1213:1220	arg1	TNF-α					1222:1226	the pro-inflammatory cytokine TNF-α	1192:1226	the pro-inflammatory cytokine TNF-α	1192:1226	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	0	31	theme	glucan	61:66	arg1	particles					68:76	yeast glucan particles	55:76	yeast glucan particles	55:76	Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro.
33340625	4	32	used	used	595:598	arg2	drying					581:586	spray drying	575:586	spray drying	575:586	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	4	32	used	used	595:598	arg2	evaporation					559:569	slurry evaporation	552:569	slurry evaporation	552:569	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	4	32	used	used	595:598	arg2	methods					542:548	Two different methods	528:548	Two different methods - slurry evaporation and spray drying -	528:588	Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared.
33340625	6	33	theme	spray	862:866	arg1	drying					868:873	spray drying	862:873	spray drying	862:873	The materials prepared by spray drying showed greater activity than those made using a rotary evaporator.
33340625	7	34	theme	transcription	1138:1150	arg1	NF-κB/AP-1					1160:1169	NF-κB/AP-1	1160:1169	NF-κB/AP-1	1160:1169	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	7	34	theme	transcription	1138:1150	arg1	secretion					1179:1187	the secretion	1175:1187	the secretion of the pro-inflammatory cytokine TNF-α	1175:1226	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	7	34	theme	transcription	1138:1150	arg1	factors					1152:1158	transcription factors	1138:1158	transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α	1138:1226	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	3	35	theme	antioxidant	496:506	arg1	potential					508:516	their anti-inflammatory and antioxidant potential	468:516	their anti-inflammatory and antioxidant potential	468:516	This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro.
33340625	7	36	theme	simple	1045:1050	arg1	suspensions					1052:1062	simple suspensions	1045:1062	simple suspensions of these compounds	1045:1081	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	7	37	theme	compounds	1073:1081	arg1	suspensions					1052:1062	simple suspensions	1045:1062	simple suspensions of these compounds	1045:1081	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	3	38	theme	anti-inflammatory	474:490	arg1	potential					508:516	their anti-inflammatory and antioxidant potential	468:516	their anti-inflammatory and antioxidant potential	468:516	This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro.
33340625	7	39	theme	activity	1126:1133	arg1	inhibition					1108:1117	their inhibition	1102:1117	their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α	1102:1226	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	5	40	theme	compounds	768:776	arg1	Several					745:751	Several	745:751	Several	745:751	Several of the natural compounds showed the beneficial effects of being combined with GPs.
33340625	2	41	theme	biological	248:257	arg1	activities					259:268	their own biological activities	238:268	their own biological activities	238:268	GPs possess their own biological activities and can act synergistically with their cargo.
33340625	2	42	contain	possess	230:236	arg2	activities					259:268	their own biological activities	238:268	their own biological activities	238:268	GPs possess their own biological activities and can act synergistically with their cargo.
33340625	2	42	contain	possess	230:236	arg1	GPs					226:228	GPs	226:228	GPs	226:228	GPs possess their own biological activities and can act synergistically with their cargo.
33340625	2	43	theme	own	244:246	arg1	activities					259:268	their own biological activities	238:268	their own biological activities	238:268	GPs possess their own biological activities and can act synergistically with their cargo.
33340625	7	44	theme	anti-inflammatory	1003:1019	arg1	potential					1021:1029	greater anti-inflammatory potential	995:1029	greater anti-inflammatory potential	995:1029	Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
33340625	1	45	theme	promising	149:157	arg1	particles					129:137	Yeast glucan particles	116:137	Yeast glucan particles (GPs)	116:143	Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs.
33340625	1	45	theme	promising	149:157	arg1	agents					159:164	promising agents	149:164	promising agents for the delivery of biologically active compounds as drugs	149:223	Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs.
33576066	2	0	theme	size	271:274	arg1	range					276:280	5-50 μm size range	263:280	5-50 μm size range	263:280	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	5	1	theme	GA	822:823	arg1	microgels					825:833	Pristine GA microgels	813:833	Pristine GA microgels	813:833	Pristine GA microgels, and the nanocomposite microgels were thoroughly characterized through FTIR, DSC, TGA, XRD, SEM, EDS, and TEM.
33576066	10	2	theme	antioxidant	1782:1792	arg1	properties					1794:1803	excellent antioxidant properties	1772:1803	excellent antioxidant properties	1772:1803	Moreover, excellent antioxidant properties were found for both the GNAg and GNCo nanocomposites as compared to pristine GA microgels.
33576066	1	3	theme	multifunctional	169:183	arg1	application					196:206	multifunctional biomedical application	169:206	multifunctional biomedical application	169:206	We report novel gum acacia (GA) based microgels composites for multifunctional biomedical application.
33576066	11	4	from	GNAg	1966:1969	arg1	nature					1923:1928	A remarkable biocompatible nature	1896:1928	A remarkable biocompatible nature of the nanocomposites in particular GNAg	1896:1969	A remarkable biocompatible nature of the nanocomposites in particular GNAg makes the novel GA composites, to be exploited for diverse biomedical applications.
33576066	11	5	theme	biomedical	2030:2039	arg1	applications					2041:2052	diverse biomedical applications	2022:2052	diverse biomedical applications	2022:2052	A remarkable biocompatible nature of the nanocomposites in particular GNAg makes the novel GA composites, to be exploited for diverse biomedical applications.
33576066	11	6	theme	remarkable	1898:1907	arg1	nature					1923:1928	A remarkable biocompatible nature	1896:1928	A remarkable biocompatible nature of the nanocomposites in particular GNAg	1896:1969	A remarkable biocompatible nature of the nanocomposites in particular GNAg makes the novel GA composites, to be exploited for diverse biomedical applications.
33576066	2	7	theme	spherical	223:231	arg1	particles					246:254	spherical GA microgels particles	223:254	spherical GA microgels particles within 5-50 μm size range	223:280	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	1	8	theme	novel	116:120	arg1	GA					134:135	GA	134:135	GA	134:135	We report novel gum acacia (GA) based microgels composites for multifunctional biomedical application.
33576066	1	8	theme	novel	116:120	arg1	acacia					126:131	novel gum acacia	116:131	novel gum acacia (GA) based microgels composites for multifunctional biomedical application	116:206	We report novel gum acacia (GA) based microgels composites for multifunctional biomedical application.
33576066	3	9	theme	GNCo	575:578	arg1	microgels					594:602	GNCo nanocomposite microgels	575:602	GNCo nanocomposite microgels	575:602	The prepared microgels were then utilized for in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis to subsequently produce GNAg and GNCo nanocomposite microgels, respectively.
33576066	6	10	theme	biocompatibility	1151:1166	arg1	investigation					1168:1180	biocompatibility investigation	1151:1180	multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation	1046:1180	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	4	11	theme	sizes	671:675	arg1	particle					636:643	particle	636:643	particle of almost less than 40 nm sizes	636:675	Ag and Co NPs of particle of almost less than 40 nm sizes were homogenously distributed over the matrices of the prepared microgels, and therefore, negligible agglomeration effect was observed.
33576066	3	12	theme	nanocomposite	580:592	arg1	microgels					594:602	GNCo nanocomposite microgels	575:602	GNCo nanocomposite microgels	575:602	The prepared microgels were then utilized for in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis to subsequently produce GNAg and GNCo nanocomposite microgels, respectively.
33576066	1	13	theme	acacia	126:131	arg1	composites					154:163	novel gum acacia (GA) based microgels composites	116:163	novel gum acacia (GA) based microgels composites for multifunctional biomedical application	116:206	We report novel gum acacia (GA) based microgels composites for multifunctional biomedical application.
33576066	8	14	theme	47.73	1475:1479	arg1	%					1480:1480	%	1480:1480	%	1480:1480	Among the prepared samples, GNAg nanocomposites were highly active against Fusarium oxysporum and Aspergillus niger that show 47.73% ± 0.25 inhibition and 32.3% ± 2.0 with IC-50 of 220 μg ml-1 and 343 μg ml-1 , respectively.
33576066	7	15	theme	pristine	1326:1333	arg1	microgels					1338:1346	pristine GA microgels	1326:1346	pristine GA microgels	1326:1346	Our results demonstrate that the prepared nanocomposites in particular GNAg microgels exhibited excellent biomedical properties as compared to pristine GA microgels.
33576066	11	16	theme	nanocomposites	1937:1950	arg1	nature					1923:1928	A remarkable biocompatible nature	1896:1928	A remarkable biocompatible nature of the nanocomposites in particular GNAg	1896:1969	A remarkable biocompatible nature of the nanocomposites in particular GNAg makes the novel GA composites, to be exploited for diverse biomedical applications.
33576066	4	17	theme	particle	636:643	arg1	NPs					629:631	Ag and Co NPs	619:631	Ag and Co NPs of particle of almost less than 40 nm sizes	619:675	Ag and Co NPs of particle of almost less than 40 nm sizes were homogenously distributed over the matrices of the prepared microgels, and therefore, negligible agglomeration effect was observed.
33576066	0	18	theme	metal	57:61	arg1	nanoparticles					63:75	metal nanoparticles	57:75	metal nanoparticles	57:75	Synthesis, characterization, and biological screening of metal nanoparticles loaded gum acacia microgels.
33576066	2	19	theme	microgels	236:244	arg1	particles					246:254	spherical GA microgels particles	223:254	spherical GA microgels particles within 5-50 μm size range	223:280	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	2	20	from	medium	422:427	arg1	micelles					339:346	the reverse micelles	327:346	the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium	327:427	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	11	21	from	nature	1923:1928	arg1	GNAg					1966:1969	particular GNAg	1955:1969	particular GNAg	1955:1969	A remarkable biocompatible nature of the nanocomposites in particular GNAg makes the novel GA composites, to be exploited for diverse biomedical applications.
33576066	11	22	theme	novel	1981:1985	arg1	composites					1990:1999	the novel GA composites	1977:1999	the novel GA composites	1977:1999	A remarkable biocompatible nature of the nanocomposites in particular GNAg makes the novel GA composites, to be exploited for diverse biomedical applications.
33576066	1	23	theme	based	138:142	arg1	composites					154:163	novel gum acacia (GA) based microgels composites	116:163	novel gum acacia (GA) based microgels composites for multifunctional biomedical application	116:206	We report novel gum acacia (GA) based microgels composites for multifunctional biomedical application.
33576066	2	24	from	polymer	316:322	arg1	micelles					339:346	the reverse micelles	327:346	the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium	327:427	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	0	25	theme	acacia	88:93	arg1	microgels					95:103	gum acacia microgels	84:103	gum acacia microgels	84:103	Synthesis, characterization, and biological screening of metal nanoparticles loaded gum acacia microgels.
33576066	3	26	dep	in	476:477	arg1	situ					479:482	situ	479:482	situ	479:482	The prepared microgels were then utilized for in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis to subsequently produce GNAg and GNCo nanocomposite microgels, respectively.
33576066	6	27	theme	GA	978:979	arg1	microgels					981:989	The well-characterized pristine GA microgels	946:989	The well-characterized pristine GA microgels	946:989	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	11	28	theme	biocompatible	1909:1921	arg1	nature					1923:1928	A remarkable biocompatible nature	1896:1928	A remarkable biocompatible nature of the nanocomposites in particular GNAg	1896:1969	A remarkable biocompatible nature of the nanocomposites in particular GNAg makes the novel GA composites, to be exploited for diverse biomedical applications.
33576066	6	29	theme	nanocomposite	999:1011	arg1	microgels					1013:1021	the nanocomposite microgels	995:1021	the nanocomposite microgels	995:1021	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	2	30	theme	particles	246:254	arg1	yield					214:218	High yield	209:218	High yield of spherical GA microgels particles within 5-50 μm size range	209:280	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	3	31	used	utilized	463:470	arg2	microgels					443:451	The prepared microgels	430:451	The prepared microgels	430:451	The prepared microgels were then utilized for in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis to subsequently produce GNAg and GNCo nanocomposite microgels, respectively.
33576066	2	32	theme	gasoline	413:420	arg1	medium					422:427	gasoline medium	413:427	gasoline medium	413:427	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	9	33	theme	Moderate	1574:1581	arg1	activity					1596:1603	Moderate antidiabetic activity	1574:1603	Moderate antidiabetic activity	1574:1603	Moderate antidiabetic activity was also observed for GNAg nanocomposites with considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively.
33576066	7	34	theme	biomedical	1289:1298	arg1	properties					1300:1309	excellent biomedical properties	1279:1309	excellent biomedical properties	1279:1309	Our results demonstrate that the prepared nanocomposites in particular GNAg microgels exhibited excellent biomedical properties as compared to pristine GA microgels.
33576066	8	35	theme	GNAg	1377:1380	arg1	nanocomposites					1382:1395	GNAg nanocomposites	1377:1395	GNAg nanocomposites	1377:1395	Among the prepared samples, GNAg nanocomposites were highly active against Fusarium oxysporum and Aspergillus niger that show 47.73% ± 0.25 inhibition and 32.3% ± 2.0 with IC-50 of 220 μg ml-1 and 343 μg ml-1 , respectively.
33576066	5	36	theme	Pristine	813:820	arg1	microgels					825:833	Pristine GA microgels	813:833	Pristine GA microgels	813:833	Pristine GA microgels, and the nanocomposite microgels were thoroughly characterized through FTIR, DSC, TGA, XRD, SEM, EDS, and TEM.
33576066	6	37	theme	well-characterized	950:967	arg1	microgels					981:989	The well-characterized pristine GA microgels	946:989	The well-characterized pristine GA microgels	946:989	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	4	38	theme	agglomeration	778:790	arg1	effect					792:797	negligible agglomeration effect	767:797	negligible agglomeration effect	767:797	Ag and Co NPs of particle of almost less than 40 nm sizes were homogenously distributed over the matrices of the prepared microgels, and therefore, negligible agglomeration effect was observed.
33576066	7	39	theme	GNAg	1254:1257	arg1	microgels					1259:1267	particular GNAg microgels	1243:1267	particular GNAg microgels	1243:1267	Our results demonstrate that the prepared nanocomposites in particular GNAg microgels exhibited excellent biomedical properties as compared to pristine GA microgels.
33576066	11	40	theme	GA	1987:1988	arg1	composites					1990:1999	the novel GA composites	1977:1999	the novel GA composites	1977:1999	A remarkable biocompatible nature of the nanocomposites in particular GNAg makes the novel GA composites, to be exploited for diverse biomedical applications.
33576066	2	41	theme	5-50 μm	263:269	arg1	range					276:280	5-50 μm size range	263:280	5-50 μm size range	263:280	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	6	42	dep	in	1055:1056	arg1	vitro					1058:1062	vitro	1058:1062	vitro	1058:1062	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	6	43	theme	multiple	1046:1053	arg1	antidiabetic					1097:1108	antidiabetic	1097:1108	antidiabetic	1097:1108	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	6	43	theme	multiple	1046:1053	arg1	activities					1129:1138	antimicrobial activities	1115:1138	antimicrobial activities	1115:1138	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	6	43	theme	multiple	1046:1053	arg1	antioxidant					1084:1094	antioxidant	1084:1094	antioxidant	1084:1094	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	6	43	theme	multiple	1046:1053	arg1	bioassays					1064:1072	multiple in vitro bioassays	1046:1072	multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation	1046:1180	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	10	44	theme	pristine	1873:1880	arg1	microgels					1885:1893	pristine GA microgels	1873:1893	pristine GA microgels	1873:1893	Moreover, excellent antioxidant properties were found for both the GNAg and GNCo nanocomposites as compared to pristine GA microgels.
33576066	7	45	theme	prepared	1216:1223	arg1	nanocomposites					1225:1238	the prepared nanocomposites	1212:1238	the prepared nanocomposites in particular GNAg microgels	1212:1267	Our results demonstrate that the prepared nanocomposites in particular GNAg microgels exhibited excellent biomedical properties as compared to pristine GA microgels.
33576066	2	46	theme	surfactant-sodium	351:367	arg1	sulfosuccinate					388:401	surfactant-sodium bis (2-ethylhexyl) sulfosuccinate	351:401	surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium	351:427	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	2	46	theme	surfactant-sodium	351:367	arg1	NBSS					404:407	NBSS	404:407	NBSS	404:407	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	8	47	theme	 ± 0.25	1481:1487	arg1	inhibition					1489:1498	47.73% ± 0.25 inhibition	1475:1498	47.73% ± 0.25 inhibition	1475:1498	Among the prepared samples, GNAg nanocomposites were highly active against Fusarium oxysporum and Aspergillus niger that show 47.73% ± 0.25 inhibition and 32.3% ± 2.0 with IC-50 of 220 μg ml-1 and 343 μg ml-1 , respectively.
33576066	9	48	theme	considerable	1652:1663	arg1	inhibition					1665:1674	considerable inhibition	1652:1674	considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively	1652:1759	Moderate antidiabetic activity was also observed for GNAg nanocomposites with considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively.
33576066	2	49	from	micelles	339:346	arg1	medium					422:427	gasoline medium	413:427	gasoline medium	413:427	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	6	50	theme	antimicrobial	1115:1127	arg1	activities					1129:1138	antimicrobial activities	1115:1138	antimicrobial activities	1115:1138	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	3	51	theme	cobalt	500:505	arg1	NPs					527:529	NPs	527:529	NPs	527:529	The prepared microgels were then utilized for in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis to subsequently produce GNAg and GNCo nanocomposite microgels, respectively.
33576066	3	51	theme	cobalt	500:505	arg1	nanoparticles					512:524	cobalt (Co) nanoparticles	500:524	cobalt (Co) nanoparticles (NPs)	500:530	The prepared microgels were then utilized for in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis to subsequently produce GNAg and GNCo nanocomposite microgels, respectively.
33576066	1	52	theme	microgels	144:152	arg1	composites					154:163	novel gum acacia (GA) based microgels composites	116:163	novel gum acacia (GA) based microgels composites for multifunctional biomedical application	116:206	We report novel gum acacia (GA) based microgels composites for multifunctional biomedical application.
33576066	9	53	theme	%	1684:1684	arg1	inhibition					1665:1674	considerable inhibition	1652:1674	considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively	1652:1759	Moderate antidiabetic activity was also observed for GNAg nanocomposites with considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively.
33576066	7	54	from	nanocomposites	1225:1238	arg1	microgels					1259:1267	particular GNAg microgels	1243:1267	particular GNAg microgels	1243:1267	Our results demonstrate that the prepared nanocomposites in particular GNAg microgels exhibited excellent biomedical properties as compared to pristine GA microgels.
33576066	4	55	theme	Ag	619:620	arg1	NPs					629:631	Ag and Co NPs	619:631	Ag and Co NPs of particle of almost less than 40 nm sizes	619:675	Ag and Co NPs of particle of almost less than 40 nm sizes were homogenously distributed over the matrices of the prepared microgels, and therefore, negligible agglomeration effect was observed.
33576066	4	56	theme	Co	626:627	arg1	NPs					629:631	Ag and Co NPs	619:631	Ag and Co NPs of particle of almost less than 40 nm sizes	619:675	Ag and Co NPs of particle of almost less than 40 nm sizes were homogenously distributed over the matrices of the prepared microgels, and therefore, negligible agglomeration effect was observed.
33576066	10	57	theme	excellent	1772:1780	arg1	properties					1794:1803	excellent antioxidant properties	1772:1803	excellent antioxidant properties	1772:1803	Moreover, excellent antioxidant properties were found for both the GNAg and GNCo nanocomposites as compared to pristine GA microgels.
33576066	1	58	theme	biomedical	185:194	arg1	application					196:206	multifunctional biomedical application	169:206	multifunctional biomedical application	169:206	We report novel gum acacia (GA) based microgels composites for multifunctional biomedical application.
33576066	9	59	theme	%	1701:1701	arg1	inhibition					1665:1674	considerable inhibition	1652:1674	considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively	1652:1759	Moderate antidiabetic activity was also observed for GNAg nanocomposites with considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively.
33576066	2	60	theme	reverse	331:337	arg1	micelles					339:346	the reverse micelles	327:346	the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium	327:427	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	2	61	theme	GA	233:234	arg1	particles					246:254	spherical GA microgels particles	223:254	spherical GA microgels particles within 5-50 μm size range	223:280	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	11	62	theme	particular	1955:1964	arg1	GNAg					1966:1969	particular GNAg	1955:1969	particular GNAg	1955:1969	A remarkable biocompatible nature of the nanocomposites in particular GNAg makes the novel GA composites, to be exploited for diverse biomedical applications.
33576066	11	63	from	nanocomposites	1937:1950	arg1	GNAg					1966:1969	particular GNAg	1955:1969	particular GNAg	1955:1969	A remarkable biocompatible nature of the nanocomposites in particular GNAg makes the novel GA composites, to be exploited for diverse biomedical applications.
33576066	4	64	theme	microgels	741:749	arg1	matrices					716:723	the matrices	712:723	the matrices of the prepared microgels	712:749	Ag and Co NPs of particle of almost less than 40 nm sizes were homogenously distributed over the matrices of the prepared microgels, and therefore, negligible agglomeration effect was observed.
33576066	10	65	theme	GNCo	1838:1841	arg1	nanocomposites					1843:1856	both the GNAg and GNCo nanocomposites	1820:1856	nanocomposites	1843:1856	Moreover, excellent antioxidant properties were found for both the GNAg and GNCo nanocomposites as compared to pristine GA microgels.
33576066	1	66	theme	gum	122:124	arg1	GA					134:135	GA	134:135	GA	134:135	We report novel gum acacia (GA) based microgels composites for multifunctional biomedical application.
33576066	1	66	theme	gum	122:124	arg1	acacia					126:131	novel gum acacia	116:131	novel gum acacia (GA) based microgels composites for multifunctional biomedical application	116:206	We report novel gum acacia (GA) based microgels composites for multifunctional biomedical application.
33576066	3	67	theme	nanoparticles	512:524	arg1	synthesis					532:540	in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis	476:540	in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis	476:540	The prepared microgels were then utilized for in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis to subsequently produce GNAg and GNCo nanocomposite microgels, respectively.
33576066	8	68	theme	%	1480:1480	arg1	inhibition					1489:1498	47.73% ± 0.25 inhibition	1475:1498	47.73% ± 0.25 inhibition	1475:1498	Among the prepared samples, GNAg nanocomposites were highly active against Fusarium oxysporum and Aspergillus niger that show 47.73% ± 0.25 inhibition and 32.3% ± 2.0 with IC-50 of 220 μg ml-1 and 343 μg ml-1 , respectively.
33576066	0	69	theme	nanoparticles	63:75	arg1	characterization					11:26	characterization	11:26	characterization	11:26	Synthesis, characterization, and biological screening of metal nanoparticles loaded gum acacia microgels.
33576066	0	69	theme	nanoparticles	63:75	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis, characterization, and biological screening of metal nanoparticles loaded gum acacia microgels.
33576066	0	69	theme	nanoparticles	63:75	arg1	screening					44:52	biological screening	33:52	biological screening	33:52	Synthesis, characterization, and biological screening of metal nanoparticles loaded gum acacia microgels.
33576066	10	70	theme	GNAg	1829:1832	arg1	nanocomposites					1843:1856	both the GNAg and GNCo nanocomposites	1820:1856	nanocomposites	1843:1856	Moreover, excellent antioxidant properties were found for both the GNAg and GNCo nanocomposites as compared to pristine GA microgels.
33576066	11	71	theme	diverse	2022:2028	arg1	applications					2041:2052	diverse biomedical applications	2022:2052	diverse biomedical applications	2022:2052	A remarkable biocompatible nature of the nanocomposites in particular GNAg makes the novel GA composites, to be exploited for diverse biomedical applications.
33576066	7	72	theme	GA	1335:1336	arg1	microgels					1338:1346	pristine GA microgels	1326:1346	pristine GA microgels	1326:1346	Our results demonstrate that the prepared nanocomposites in particular GNAg microgels exhibited excellent biomedical properties as compared to pristine GA microgels.
33576066	0	73	theme	gum	84:86	arg1	microgels					95:103	gum acacia microgels	84:103	gum acacia microgels	84:103	Synthesis, characterization, and biological screening of metal nanoparticles loaded gum acacia microgels.
33576066	5	74	theme	nanocomposite	844:856	arg1	microgels					858:866	the nanocomposite microgels	840:866	the nanocomposite microgels	840:866	Pristine GA microgels, and the nanocomposite microgels were thoroughly characterized through FTIR, DSC, TGA, XRD, SEM, EDS, and TEM.
33576066	2	75	theme	sulfosuccinate	388:401	arg1	micelles					339:346	the reverse micelles	327:346	the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium	327:427	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	8	76	theme	220 μg ml-1	1530:1540	arg1	IC-50					1521:1525	IC-50	1521:1525	IC-50 of 220 μg ml-1 and 343 μg ml-1	1521:1556	Among the prepared samples, GNAg nanocomposites were highly active against Fusarium oxysporum and Aspergillus niger that show 47.73% ± 0.25 inhibition and 32.3% ± 2.0 with IC-50 of 220 μg ml-1 and 343 μg ml-1 , respectively.
33576066	2	77	theme	2-ethylhexyl	374:385	arg1	sulfosuccinate					388:401	surfactant-sodium bis (2-ethylhexyl) sulfosuccinate	351:401	surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium	351:427	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	2	77	theme	2-ethylhexyl	374:385	arg1	NBSS					404:407	NBSS	404:407	NBSS	404:407	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	7	78	theme	excellent	1279:1287	arg1	properties					1300:1309	excellent biomedical properties	1279:1309	excellent biomedical properties	1279:1309	Our results demonstrate that the prepared nanocomposites in particular GNAg microgels exhibited excellent biomedical properties as compared to pristine GA microgels.
33576066	8	79	theme	343 μg ml-1	1546:1556	arg1	IC-50					1521:1525	IC-50	1521:1525	IC-50 of 220 μg ml-1 and 343 μg ml-1	1521:1556	Among the prepared samples, GNAg nanocomposites were highly active against Fusarium oxysporum and Aspergillus niger that show 47.73% ± 0.25 inhibition and 32.3% ± 2.0 with IC-50 of 220 μg ml-1 and 343 μg ml-1 , respectively.
33576066	8	80	theme	prepared	1359:1366	arg1	samples					1368:1374	the prepared samples	1355:1374	the prepared samples	1355:1374	Among the prepared samples, GNAg nanocomposites were highly active against Fusarium oxysporum and Aspergillus niger that show 47.73% ± 0.25 inhibition and 32.3% ± 2.0 with IC-50 of 220 μg ml-1 and 343 μg ml-1 , respectively.
33576066	0	81	theme	biological	33:42	arg1	screening					44:52	biological screening	33:52	biological screening	33:52	Synthesis, characterization, and biological screening of metal nanoparticles loaded gum acacia microgels.
33576066	9	82	theme	antidiabetic	1583:1594	arg1	activity					1596:1603	Moderate antidiabetic activity	1574:1603	Moderate antidiabetic activity	1574:1603	Moderate antidiabetic activity was also observed for GNAg nanocomposites with considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively.
33576066	6	83	theme	pristine	969:976	arg1	microgels					981:989	The well-characterized pristine GA microgels	946:989	The well-characterized pristine GA microgels	946:989	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	7	84	theme	particular	1243:1252	arg1	microgels					1259:1267	particular GNAg microgels	1243:1267	particular GNAg microgels	1243:1267	Our results demonstrate that the prepared nanocomposites in particular GNAg microgels exhibited excellent biomedical properties as compared to pristine GA microgels.
33576066	2	85	theme	High	209:212	arg1	yield					214:218	High yield	209:218	High yield of spherical GA microgels particles within 5-50 μm size range	209:280	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	4	86	theme	negligible	767:776	arg1	effect					792:797	negligible agglomeration effect	767:797	negligible agglomeration effect	767:797	Ag and Co NPs of particle of almost less than 40 nm sizes were homogenously distributed over the matrices of the prepared microgels, and therefore, negligible agglomeration effect was observed.
33576066	3	87	theme	silver	484:489	arg1	synthesis					532:540	in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis	476:540	in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis	476:540	The prepared microgels were then utilized for in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis to subsequently produce GNAg and GNCo nanocomposite microgels, respectively.
33576066	2	88	from	sulfosuccinate	388:401	arg1	medium					422:427	gasoline medium	413:427	gasoline medium	413:427	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	6	89	theme	in	1055:1056	arg1	antidiabetic					1097:1108	antidiabetic	1097:1108	antidiabetic	1097:1108	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	6	89	theme	in	1055:1056	arg1	activities					1129:1138	antimicrobial activities	1115:1138	antimicrobial activities	1115:1138	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	6	89	theme	in	1055:1056	arg1	antioxidant					1084:1094	antioxidant	1084:1094	antioxidant	1084:1094	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	6	89	theme	in	1055:1056	arg1	bioassays					1064:1072	multiple in vitro bioassays	1046:1072	multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation	1046:1180	The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation.
33576066	10	90	theme	GA	1882:1883	arg1	microgels					1885:1893	pristine GA microgels	1873:1893	pristine GA microgels	1873:1893	Moreover, excellent antioxidant properties were found for both the GNAg and GNCo nanocomposites as compared to pristine GA microgels.
33576066	4	91	theme	prepared	732:739	arg1	microgels					741:749	the prepared microgels	728:749	the prepared microgels	728:749	Ag and Co NPs of particle of almost less than 40 nm sizes were homogenously distributed over the matrices of the prepared microgels, and therefore, negligible agglomeration effect was observed.
33576066	3	92	theme	in	476:477	arg1	Ag					492:493	Ag	492:493	Ag	492:493	The prepared microgels were then utilized for in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis to subsequently produce GNAg and GNCo nanocomposite microgels, respectively.
33576066	3	92	theme	in	476:477	arg1	silver					484:489	in situ silver	476:489	in situ silver (Ag)	476:494	The prepared microgels were then utilized for in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis to subsequently produce GNAg and GNCo nanocomposite microgels, respectively.
33576066	9	93	theme	GNAg	1627:1630	arg1	nanocomposites					1632:1645	GNAg nanocomposites	1627:1645	GNAg nanocomposites with considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively	1627:1759	Moderate antidiabetic activity was also observed for GNAg nanocomposites with considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively.
33576066	3	94	theme	prepared	434:441	arg1	microgels					443:451	The prepared microgels	430:451	The prepared microgels	430:451	The prepared microgels were then utilized for in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis to subsequently produce GNAg and GNCo nanocomposite microgels, respectively.
33576066	9	95	with	nanocomposites	1632:1645	arg1	inhibition					1665:1674	considerable inhibition	1652:1674	considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively	1652:1759	Moderate antidiabetic activity was also observed for GNAg nanocomposites with considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively.
33576066	2	96	theme	bis	369:371	arg1	sulfosuccinate					388:401	surfactant-sodium bis (2-ethylhexyl) sulfosuccinate	351:401	surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium	351:427	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
33576066	2	96	theme	bis	369:371	arg1	NBSS					404:407	NBSS	404:407	NBSS	404:407	High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactant-sodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium.
32234435	1	0	theme	sustained	317:325	arg1	release					327:333	sustained release	317:333	sustained release of IDM	317:340	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	2	1	theme	SA/FK	581:585	arg1	fiber					587:591	SA/FK fiber	581:591	SA/FK fiber	581:591	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	3	2	theme	apparent	683:690	arg1	morphology					692:701	the apparent morphology	679:701	the apparent morphology of SA/FK fiber	679:716	Scanning electron microscope (SEM) was employed to observe the apparent morphology of SA/FK fiber.
32234435	1	3	theme	side	160:163	arg1	reaction					165:172	the serious gastrointestinal side reaction	131:172	the serious gastrointestinal side reaction of indomethacin (IDM)	131:194	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	5	4	theme	carrier	1069:1075	arg1	fiber					1077:1081	the carrier fiber	1065:1081	the carrier fiber	1065:1081	Simultaneously, FK can effectively control the release of IDM, and with the increase of FK content, IDM release time of the carrier fiber extends.
32234435	2	5	theme	Ultraviolet-visible	469:487	arg1	spectroscopy					498:509	Ultraviolet-visible (UV-Vis) spectroscopy	469:509	Ultraviolet-visible (UV-Vis) spectroscopy	469:509	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	0	6	theme	sustained	94:102	arg1	release					109:115	sustained drug release	94:115	sustained drug release	94:115	A sodium alginate/feather keratin composite fiber with skin-core structure as the carrier for sustained drug release.
32234435	2	7	used	used	515:518	arg2	spectroscopy					498:509	Ultraviolet-visible (UV-Vis) spectroscopy	469:509	Ultraviolet-visible (UV-Vis) spectroscopy	469:509	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	2	8	theme	UV-Vis	490:495	arg1	spectroscopy					498:509	Ultraviolet-visible (UV-Vis) spectroscopy	469:509	Ultraviolet-visible (UV-Vis) spectroscopy	469:509	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	1	9	theme	IDM	338:340	arg1	release					327:333	sustained release	317:333	sustained release of IDM	317:340	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	2	10	theme	release	561:567	arg1	capacity					569:576	the sustained release capacity	547:576	the sustained release capacity of SA/FK fiber in three simulated fluids	547:617	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	4	11	theme	intestinal	886:895	arg1	fluid					897:901	small intestinal fluid	880:901	small intestinal fluid	880:901	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	5	12	theme	IDM	1003:1005	arg1	release					992:998	the release	988:998	the release of IDM	988:1005	Simultaneously, FK can effectively control the release of IDM, and with the increase of FK content, IDM release time of the carrier fiber extends.
32234435	2	13	theme	simulated	602:610	arg1	fluids					612:617	three simulated fluids	596:617	three simulated fluids	596:617	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	4	14	theme	release	816:822	arg1	IDM					834:836	IDM	834:836	IDM	834:836	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	4	14	theme	release	816:822	arg1	amount					824:829	the release amount	812:829	the release amount of IDM	812:836	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	0	15	theme	drug	104:107	arg1	release					109:115	sustained drug release	94:115	sustained drug release	94:115	A sodium alginate/feather keratin composite fiber with skin-core structure as the carrier for sustained drug release.
32234435	4	16	theme	digestive	928:936	arg1	fluid					938:942	digestive fluid	928:942	digestive fluid	928:942	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	1	17	theme	indomethacin	177:188	arg1	reaction					165:172	the serious gastrointestinal side reaction	131:172	the serious gastrointestinal side reaction of indomethacin (IDM)	131:194	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	0	18	theme	sodium	2:7	arg1	fiber					44:48	A sodium alginate/feather keratin composite fiber	0:48	A sodium alginate/feather keratin composite fiber with skin-core structure as the carrier for sustained drug release.	0:116	A sodium alginate/feather keratin composite fiber with skin-core structure as the carrier for sustained drug release.
32234435	3	19	theme	fiber	712:716	arg1	morphology					692:701	the apparent morphology	679:701	the apparent morphology of SA/FK fiber	679:716	Scanning electron microscope (SEM) was employed to observe the apparent morphology of SA/FK fiber.
32234435	5	20	theme	release	1049:1055	arg1	time					1057:1060	IDM release time	1045:1060	IDM release time of the carrier fiber	1045:1081	Simultaneously, FK can effectively control the release of IDM, and with the increase of FK content, IDM release time of the carrier fiber extends.
32234435	2	21	theme	reaction	424:431	arg1	mechanism					433:441	the reaction mechanism	420:441	the reaction mechanism among SA, FK and IDM	420:462	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	2	22	from	capacity	569:576	arg1	fluids					612:617	three simulated fluids	596:617	three simulated fluids	596:617	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	2	23	theme	fiber	587:591	arg1	capacity					569:576	the sustained release capacity	547:576	the sustained release capacity of SA/FK fiber in three simulated fluids	547:617	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	2	24	theme	infrared	363:370	arg1	spectroscopy					380:391	Fourier translation infrared (FT-IR) spectroscopy	343:391	Fourier translation infrared (FT-IR) spectroscopy	343:391	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	0	25	theme	keratin	26:32	arg1	fiber					44:48	A sodium alginate/feather keratin composite fiber	0:48	A sodium alginate/feather keratin composite fiber with skin-core structure as the carrier for sustained drug release.	0:116	A sodium alginate/feather keratin composite fiber with skin-core structure as the carrier for sustained drug release.
32234435	4	26	theme	small	880:884	arg1	fluid					897:901	small intestinal fluid	880:901	small intestinal fluid	880:901	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	0	27	theme	alginate/feather	9:24	arg1	fiber					44:48	A sodium alginate/feather keratin composite fiber	0:48	A sodium alginate/feather keratin composite fiber with skin-core structure as the carrier for sustained drug release.	0:116	A sodium alginate/feather keratin composite fiber with skin-core structure as the carrier for sustained drug release.
32234435	3	28	theme	SA/FK	706:710	arg1	fiber					712:716	SA/FK fiber	706:716	SA/FK fiber	706:716	Scanning electron microscope (SEM) was employed to observe the apparent morphology of SA/FK fiber.
32234435	3	29	theme	Scanning	620:627	arg1	SEM					650:652	SEM	650:652	SEM	650:652	Scanning electron microscope (SEM) was employed to observe the apparent morphology of SA/FK fiber.
32234435	3	29	theme	Scanning	620:627	arg1	microscope					638:647	Scanning electron microscope	620:647	Scanning electron microscope (SEM)	620:653	Scanning electron microscope (SEM) was employed to observe the apparent morphology of SA/FK fiber.
32234435	2	30	theme	translation	351:361	arg1	spectroscopy					380:391	Fourier translation infrared (FT-IR) spectroscopy	343:391	Fourier translation infrared (FT-IR) spectroscopy	343:391	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	1	31	theme	wet	285:287	arg1	spinning					289:296	wet spinning	285:296	wet spinning	285:296	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	4	32	theme	colon	864:868	arg1	fluid					870:874	colon fluid	864:874	colon fluid	864:874	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	3	33	theme	electron	629:636	arg1	SEM					650:652	SEM	650:652	SEM	650:652	Scanning electron microscope (SEM) was employed to observe the apparent morphology of SA/FK fiber.
32234435	3	33	theme	electron	629:636	arg1	microscope					638:647	Scanning electron microscope	620:647	Scanning electron microscope (SEM)	620:653	Scanning electron microscope (SEM) was employed to observe the apparent morphology of SA/FK fiber.
32234435	1	34	theme	sodium	197:202	arg1	fiber					237:241	sodium alginate/feather keratin (SA/FK) fiber	197:241	sodium alginate/feather keratin (SA/FK) fiber with skin-core structure	197:266	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	1	34	theme	sodium	197:202	arg1	carrier					305:311	the carrier	301:311	the carrier for sustained release of IDM	301:340	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	0	35	theme	composite	34:42	arg1	fiber					44:48	A sodium alginate/feather keratin composite fiber	0:48	A sodium alginate/feather keratin composite fiber with skin-core structure as the carrier for sustained drug release.	0:116	A sodium alginate/feather keratin composite fiber with skin-core structure as the carrier for sustained drug release.
32234435	4	36	from	%	923:923	arg1	fluid					938:942	digestive fluid	928:942	digestive fluid	928:942	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	5	37	theme	fiber	1077:1081	arg1	time					1057:1060	IDM release time	1045:1060	IDM release time of the carrier fiber	1045:1081	Simultaneously, FK can effectively control the release of IDM, and with the increase of FK content, IDM release time of the carrier fiber extends.
32234435	1	38	theme	alginate/feather	204:219	arg1	fiber					237:241	sodium alginate/feather keratin (SA/FK) fiber	197:241	sodium alginate/feather keratin (SA/FK) fiber with skin-core structure	197:266	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	1	38	theme	alginate/feather	204:219	arg1	carrier					305:311	the carrier	301:311	the carrier for sustained release of IDM	301:340	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	0	39	theme	skin-core	55:63	arg1	structure					65:73	skin-core structure	55:73	skin-core structure	55:73	A sodium alginate/feather keratin composite fiber with skin-core structure as the carrier for sustained drug release.
32234435	5	40	theme	FK	1033:1034	arg1	content					1036:1042	FK content	1033:1042	FK content	1033:1042	Simultaneously, FK can effectively control the release of IDM, and with the increase of FK content, IDM release time of the carrier fiber extends.
32234435	2	41	theme	sustained	551:559	arg1	capacity					569:576	the sustained release capacity	547:576	the sustained release capacity of SA/FK fiber in three simulated fluids	547:617	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	4	42	theme	IDM	834:836	arg1	IDM					834:836	IDM	834:836	IDM	834:836	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	4	42	theme	IDM	834:836	arg1	amount					824:829	the release amount	812:829	the release amount of IDM	812:836	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	4	43	theme	increase	780:787	arg1	trend					789:793	an increase trend	777:793	an increase trend	777:793	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	1	44	with	fiber	237:241	arg1	structure					258:266	skin-core structure	248:266	skin-core structure	248:266	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	5	45	theme	IDM	1045:1047	arg1	time					1057:1060	IDM release time	1045:1060	IDM release time of the carrier fiber	1045:1081	Simultaneously, FK can effectively control the release of IDM, and with the increase of FK content, IDM release time of the carrier fiber extends.
32234435	1	46	theme	keratin	221:227	arg1	fiber					237:241	sodium alginate/feather keratin (SA/FK) fiber	197:241	sodium alginate/feather keratin (SA/FK) fiber with skin-core structure	197:266	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	1	46	theme	keratin	221:227	arg1	carrier					305:311	the carrier	301:311	the carrier for sustained release of IDM	301:340	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	4	47	theme	release	746:752	arg1	IDM					764:766	IDM	764:766	IDM	764:766	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	4	47	theme	release	746:752	arg1	amount					754:759	release amount	746:759	release amount of IDM	746:766	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	2	48	theme	Fourier	343:349	arg1	spectroscopy					380:391	Fourier translation infrared (FT-IR) spectroscopy	343:391	Fourier translation infrared (FT-IR) spectroscopy	343:391	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	4	49	theme	IDM	764:766	arg1	IDM					764:766	IDM	764:766	IDM	764:766	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	4	49	theme	IDM	764:766	arg1	amount					754:759	release amount	746:759	release amount of IDM	746:766	The results indicate that, release amount of IDM exhibits an increase trend along with time; the release amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, and is less than 20% in digestive fluid.
32234435	1	50	theme	serious	135:141	arg1	reaction					165:172	the serious gastrointestinal side reaction	131:172	the serious gastrointestinal side reaction of indomethacin (IDM)	131:194	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	2	51	theme	FT-IR	373:377	arg1	spectroscopy					380:391	Fourier translation infrared (FT-IR) spectroscopy	343:391	Fourier translation infrared (FT-IR) spectroscopy	343:391	Fourier translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was used to systematically evaluate the sustained release capacity of SA/FK fiber in three simulated fluids.
32234435	1	52	theme	SA/FK	230:234	arg1	fiber					237:241	sodium alginate/feather keratin (SA/FK) fiber	197:241	sodium alginate/feather keratin (SA/FK) fiber with skin-core structure	197:266	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	1	52	theme	SA/FK	230:234	arg1	carrier					305:311	the carrier	301:311	the carrier for sustained release of IDM	301:340	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	1	53	theme	skin-core	248:256	arg1	structure					258:266	skin-core structure	248:266	skin-core structure	248:266	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	0	54	with	fiber	44:48	arg1	structure					65:73	skin-core structure	55:73	skin-core structure	55:73	A sodium alginate/feather keratin composite fiber with skin-core structure as the carrier for sustained drug release.
32234435	1	55	theme	gastrointestinal	143:158	arg1	reaction					165:172	the serious gastrointestinal side reaction	131:172	the serious gastrointestinal side reaction of indomethacin (IDM)	131:194	To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was prepared via wet spinning as the carrier for sustained release of IDM.
32234435	5	56	theme	content	1036:1042	arg1	increase					1021:1028	the increase	1017:1028	the increase of FK content	1017:1042	Simultaneously, FK can effectively control the release of IDM, and with the increase of FK content, IDM release time of the carrier fiber extends.
32708305	7	0	theme	crystal	960:966	arg1	structure					968:976	the crystal structure	956:976	the crystal structure of this complex	956:992	Furthermore, we characterized the interaction between NKp30 and its best-studied cognate ligand, B7-H6, with respect to glycosylation and oligomerization, and we solved the crystal structure of this complex with glycosylated NKp30, revealing a new glycosylation-induced mode of NKp30 dimerization.
32708305	2	1	theme	structural	320:329	arg1	knowledge					331:339	our structural knowledge	316:339	our structural knowledge of NKp30 oligomerization	316:364	The oligomerization of the NKp30 ligand binding domain depends on the length of the C-terminal stalk region, but our structural knowledge of NKp30 oligomerization and its role in signal transduction remains limited.
32708305	7	2	theme	best-studied	855:866	arg1	ligand					876:881	its best-studied cognate ligand	851:881	its best-studied cognate ligand	851:881	Furthermore, we characterized the interaction between NKp30 and its best-studied cognate ligand, B7-H6, with respect to glycosylation and oligomerization, and we solved the crystal structure of this complex with glycosylated NKp30, revealing a new glycosylation-induced mode of NKp30 dimerization.
32708305	7	2	theme	best-studied	855:866	arg1	B7-H6					884:888	B7-H6	884:888	B7-H6	884:888	Furthermore, we characterized the interaction between NKp30 and its best-studied cognate ligand, B7-H6, with respect to glycosylation and oligomerization, and we solved the crystal structure of this complex with glycosylated NKp30, revealing a new glycosylation-induced mode of NKp30 dimerization.
32708305	7	3	theme	cognate	868:874	arg1	ligand					876:881	its best-studied cognate ligand	851:881	its best-studied cognate ligand	851:881	Furthermore, we characterized the interaction between NKp30 and its best-studied cognate ligand, B7-H6, with respect to glycosylation and oligomerization, and we solved the crystal structure of this complex with glycosylated NKp30, revealing a new glycosylation-induced mode of NKp30 dimerization.
32708305	7	3	theme	cognate	868:874	arg1	B7-H6					884:888	B7-H6	884:888	B7-H6	884:888	Furthermore, we characterized the interaction between NKp30 and its best-studied cognate ligand, B7-H6, with respect to glycosylation and oligomerization, and we solved the crystal structure of this complex with glycosylated NKp30, revealing a new glycosylation-induced mode of NKp30 dimerization.
32708305	9	4	theme	novel	1405:1409	arg1	immunotherapeutics					1434:1451	novel NK cell-based targeted immunotherapeutics	1405:1451	novel NK cell-based targeted immunotherapeutics	1405:1451	This furthers our understanding of the molecular mechanisms involved in NK cell activation, which is crucial for the successful design of novel NK cell-based targeted immunotherapeutics.
32708305	3	5	dep	presence	472:479	arg1	the					468:470	the	468:470	the	468:470	Moreover, ligand binding of NKp30 is affected by the presence and type of N-glycosylation.
32708305	2	6	theme	region	304:309	arg1	length					273:278	the length	269:278	the length of the C-terminal stalk region	269:309	The oligomerization of the NKp30 ligand binding domain depends on the length of the C-terminal stalk region, but our structural knowledge of NKp30 oligomerization and its role in signal transduction remains limited.
32708305	3	7	theme	NKp30	447:451	arg1	binding					436:442	ligand binding	429:442	ligand binding of NKp30	429:451	Moreover, ligand binding of NKp30 is affected by the presence and type of N-glycosylation.
32708305	3	8	theme	N-glycosylation	493:507	arg1	type					485:488	type	485:488	type	485:488	Moreover, ligand binding of NKp30 is affected by the presence and type of N-glycosylation.
32708305	3	8	theme	N-glycosylation	493:507	arg1	presence					472:479	presence	472:479	presence	472:479	Moreover, ligand binding of NKp30 is affected by the presence and type of N-glycosylation.
32708305	9	9	theme	immunotherapeutics	1434:1451	arg1	design					1395:1400	the successful design	1380:1400	the successful design of novel NK cell-based targeted immunotherapeutics	1380:1451	This furthers our understanding of the molecular mechanisms involved in NK cell activation, which is crucial for the successful design of novel NK cell-based targeted immunotherapeutics.
32708305	1	10	theme	cell	145:148	arg1	receptors					161:169	the main human natural killer (NK) cell activating receptors	110:169	the main human natural killer (NK) cell activating receptors used in directed immunotherapy	110:200	NKp30 is one of the main human natural killer (NK) cell activating receptors used in directed immunotherapy.
32708305	9	11	theme	NK	1411:1412	arg1	immunotherapeutics					1434:1451	novel NK cell-based targeted immunotherapeutics	1405:1451	novel NK cell-based targeted immunotherapeutics	1405:1451	This furthers our understanding of the molecular mechanisms involved in NK cell activation, which is crucial for the successful design of novel NK cell-based targeted immunotherapeutics.
32708305	9	12	theme	molecular	1306:1314	arg1	mechanisms					1316:1325	the molecular mechanisms	1302:1325	the molecular mechanisms involved in NK cell activation	1302:1356	This furthers our understanding of the molecular mechanisms involved in NK cell activation, which is crucial for the successful design of novel NK cell-based targeted immunotherapeutics.
32708305	2	13	from	knowledge	331:339	arg1	transduction					389:400	signal transduction	382:400	signal transduction	382:400	The oligomerization of the NKp30 ligand binding domain depends on the length of the C-terminal stalk region, but our structural knowledge of NKp30 oligomerization and its role in signal transduction remains limited.
32708305	8	14	theme	oligomerization	1162:1176	arg1	basis					1147:1151	the structural basis	1132:1151	the structural basis of NKp30 oligomerization	1132:1176	Overall, this study provides new insights into the structural basis of NKp30 oligomerization and explains how the stalk region and glycosylation of NKp30 affect its ligand affinity.
32708305	1	15	theme	activating	150:159	arg1	receptors					161:169	the main human natural killer (NK) cell activating receptors	110:169	the main human natural killer (NK) cell activating receptors used in directed immunotherapy	110:200	NKp30 is one of the main human natural killer (NK) cell activating receptors used in directed immunotherapy.
32708305	0	16	theme	Killer	8:13	arg1	Oligomerization					46:60	Natural Killer Cell Activation Receptor NKp30 Oligomerization	0:60	Natural Killer Cell Activation Receptor NKp30 Oligomerization	0:60	Natural Killer Cell Activation Receptor NKp30 Oligomerization Depends on Its N-Glycosylation.
32708305	9	17	theme	mechanisms	1316:1325	arg1	understanding					1285:1297	our understanding	1281:1297	our understanding	1281:1297	This furthers our understanding of the molecular mechanisms involved in NK cell activation, which is crucial for the successful design of novel NK cell-based targeted immunotherapeutics.
32708305	2	18	theme	stalk	298:302	arg1	region					304:309	the C-terminal stalk region	283:309	the C-terminal stalk region	283:309	The oligomerization of the NKp30 ligand binding domain depends on the length of the C-terminal stalk region, but our structural knowledge of NKp30 oligomerization and its role in signal transduction remains limited.
32708305	1	19	theme	receptors	161:169	arg1	receptors					161:169	the main human natural killer (NK) cell activating receptors	110:169	the main human natural killer (NK) cell activating receptors used in directed immunotherapy	110:200	NKp30 is one of the main human natural killer (NK) cell activating receptors used in directed immunotherapy.
32708305	1	19	theme	receptors	161:169	arg1	one					103:105	one	103:105	one	103:105	NKp30 is one of the main human natural killer (NK) cell activating receptors used in directed immunotherapy.
32708305	0	20	theme	Natural	0:6	arg1	Killer					8:13	Natural Killer	0:13	Natural Killer Cell Activation Receptor NKp30 Oligomerization	0:60	Natural Killer Cell Activation Receptor NKp30 Oligomerization Depends on Its N-Glycosylation.
32708305	7	21	theme	dimerization	1071:1082	arg1	mode					1057:1060	a new glycosylation-induced mode	1029:1060	a new glycosylation-induced mode of NKp30 dimerization	1029:1082	Furthermore, we characterized the interaction between NKp30 and its best-studied cognate ligand, B7-H6, with respect to glycosylation and oligomerization, and we solved the crystal structure of this complex with glycosylated NKp30, revealing a new glycosylation-induced mode of NKp30 dimerization.
32708305	2	22	theme	C-terminal	287:296	arg1	region					304:309	the C-terminal stalk region	283:309	the C-terminal stalk region	283:309	The oligomerization of the NKp30 ligand binding domain depends on the length of the C-terminal stalk region, but our structural knowledge of NKp30 oligomerization and its role in signal transduction remains limited.
32708305	2	23	theme	oligomerization	350:364	arg1	knowledge					331:339	our structural knowledge	316:339	our structural knowledge of NKp30 oligomerization	316:364	The oligomerization of the NKp30 ligand binding domain depends on the length of the C-terminal stalk region, but our structural knowledge of NKp30 oligomerization and its role in signal transduction remains limited.
32708305	2	23	theme	oligomerization	350:364	arg1	role					374:377	its role	370:377	its role in signal transduction	370:400	The oligomerization of the NKp30 ligand binding domain depends on the length of the C-terminal stalk region, but our structural knowledge of NKp30 oligomerization and its role in signal transduction remains limited.
32708305	0	24	theme	Activation	20:29	arg1	Oligomerization					46:60	Natural Killer Cell Activation Receptor NKp30 Oligomerization	0:60	Natural Killer Cell Activation Receptor NKp30 Oligomerization	0:60	Natural Killer Cell Activation Receptor NKp30 Oligomerization Depends on Its N-Glycosylation.
32708305	5	25	theme	cell	675:678	arg1	lines					680:684	HEK293S GnTI- cell lines	661:684	HEK293S GnTI- cell lines with simple N-glycans	661:706	Our results show that NKp30 forms oligomers when expressed in HEK293S GnTI- cell lines with simple N-glycans.
32708305	9	26	theme	cell-based	1414:1423	arg1	immunotherapeutics					1434:1451	novel NK cell-based targeted immunotherapeutics	1405:1451	novel NK cell-based targeted immunotherapeutics	1405:1451	This furthers our understanding of the molecular mechanisms involved in NK cell activation, which is crucial for the successful design of novel NK cell-based targeted immunotherapeutics.
32708305	8	27	theme	ligand	1250:1255	arg1	affinity					1257:1264	its ligand affinity	1246:1264	its ligand affinity	1246:1264	Overall, this study provides new insights into the structural basis of NKp30 oligomerization and explains how the stalk region and glycosylation of NKp30 affect its ligand affinity.
32708305	0	28	theme	Cell	15:18	arg1	Oligomerization					46:60	Natural Killer Cell Activation Receptor NKp30 Oligomerization	0:60	Natural Killer Cell Activation Receptor NKp30 Oligomerization	0:60	Natural Killer Cell Activation Receptor NKp30 Oligomerization Depends on Its N-Glycosylation.
32708305	9	29	theme	NK	1339:1340	arg1	activation					1347:1356	NK cell activation	1339:1356	NK cell activation	1339:1356	This furthers our understanding of the molecular mechanisms involved in NK cell activation, which is crucial for the successful design of novel NK cell-based targeted immunotherapeutics.
32708305	8	30	gly	glycosylation	1216:1228	arg1	NKp30					1233:1237	NKp30	1233:1237	NKp30	1233:1237	Overall, this study provides new insights into the structural basis of NKp30 oligomerization and explains how the stalk region and glycosylation of NKp30 affect its ligand affinity.
32708305	8	30	gly	glycosylation	1216:1228	arg1	ligand					1250:1255	its ligand affinity	1246:1264	its ligand affinity	1246:1264	Overall, this study provides new insights into the structural basis of NKp30 oligomerization and explains how the stalk region and glycosylation of NKp30 affect its ligand affinity.
32708305	1	31	theme	directed	179:186	arg1	immunotherapy					188:200	directed immunotherapy	179:200	directed immunotherapy	179:200	NKp30 is one of the main human natural killer (NK) cell activating receptors used in directed immunotherapy.
32708305	8	32	theme	stalk	1199:1203	arg1	region					1205:1210	the stalk region	1195:1210	the stalk region	1195:1210	Overall, this study provides new insights into the structural basis of NKp30 oligomerization and explains how the stalk region and glycosylation of NKp30 affect its ligand affinity.
32708305	9	33	theme	cell	1342:1345	arg1	activation					1347:1356	NK cell activation	1339:1356	NK cell activation	1339:1356	This furthers our understanding of the molecular mechanisms involved in NK cell activation, which is crucial for the successful design of novel NK cell-based targeted immunotherapeutics.
32708305	7	34	theme	new	1031:1033	arg1	mode					1057:1060	a new glycosylation-induced mode	1029:1060	a new glycosylation-induced mode of NKp30 dimerization	1029:1082	Furthermore, we characterized the interaction between NKp30 and its best-studied cognate ligand, B7-H6, with respect to glycosylation and oligomerization, and we solved the crystal structure of this complex with glycosylated NKp30, revealing a new glycosylation-induced mode of NKp30 dimerization.
32708305	3	35	theme	ligand	429:434	arg1	binding					436:442	ligand binding	429:442	ligand binding of NKp30	429:451	Moreover, ligand binding of NKp30 is affected by the presence and type of N-glycosylation.
32708305	8	36	theme	NKp30	1233:1237	arg1	glycosylation					1216:1228	glycosylation	1216:1228	glycosylation of NKp30	1216:1237	Overall, this study provides new insights into the structural basis of NKp30 oligomerization and explains how the stalk region and glycosylation of NKp30 affect its ligand affinity.
32708305	8	36	theme	NKp30	1233:1237	arg1	region					1205:1210	the stalk region	1195:1210	the stalk region	1195:1210	Overall, this study provides new insights into the structural basis of NKp30 oligomerization and explains how the stalk region and glycosylation of NKp30 affect its ligand affinity.
32708305	2	37	theme	signal	382:387	arg1	transduction					389:400	signal transduction	382:400	signal transduction	382:400	The oligomerization of the NKp30 ligand binding domain depends on the length of the C-terminal stalk region, but our structural knowledge of NKp30 oligomerization and its role in signal transduction remains limited.
32708305	0	38	theme	Receptor	31:38	arg1	Oligomerization					46:60	Natural Killer Cell Activation Receptor NKp30 Oligomerization	0:60	Natural Killer Cell Activation Receptor NKp30 Oligomerization	0:60	Natural Killer Cell Activation Receptor NKp30 Oligomerization Depends on Its N-Glycosylation.
32708305	5	39	theme	simple	691:696	arg1	N-glycans					698:706	simple N-glycans	691:706	simple N-glycans	691:706	Our results show that NKp30 forms oligomers when expressed in HEK293S GnTI- cell lines with simple N-glycans.
32708305	5	40	with	lines	680:684	arg1	N-glycans					698:706	simple N-glycans	691:706	simple N-glycans	691:706	Our results show that NKp30 forms oligomers when expressed in HEK293S GnTI- cell lines with simple N-glycans.
32708305	7	41	theme	glycosylation-induced	1035:1055	arg1	mode					1057:1060	a new glycosylation-induced mode	1029:1060	a new glycosylation-induced mode of NKp30 dimerization	1029:1082	Furthermore, we characterized the interaction between NKp30 and its best-studied cognate ligand, B7-H6, with respect to glycosylation and oligomerization, and we solved the crystal structure of this complex with glycosylated NKp30, revealing a new glycosylation-induced mode of NKp30 dimerization.
32708305	2	42	from	role	374:377	arg1	transduction					389:400	signal transduction	382:400	signal transduction	382:400	The oligomerization of the NKp30 ligand binding domain depends on the length of the C-terminal stalk region, but our structural knowledge of NKp30 oligomerization and its role in signal transduction remains limited.
32708305	1	43	theme	main	114:117	arg1	receptors					161:169	the main human natural killer (NK) cell activating receptors	110:169	the main human natural killer (NK) cell activating receptors used in directed immunotherapy	110:200	NKp30 is one of the main human natural killer (NK) cell activating receptors used in directed immunotherapy.
32708305	5	44	theme	HEK293S	661:667	arg1	lines					680:684	HEK293S GnTI- cell lines	661:684	HEK293S GnTI- cell lines with simple N-glycans	661:706	Our results show that NKp30 forms oligomers when expressed in HEK293S GnTI- cell lines with simple N-glycans.
32708305	6	45	theme	enzymatic	760:768	arg1	deglycosylation					770:784	enzymatic deglycosylation	760:784	enzymatic deglycosylation	760:784	However, NKp30 was detected only as monomers after enzymatic deglycosylation.
32708305	2	46	theme	domain	251:256	arg1	oligomerization					207:221	The oligomerization	203:221	The oligomerization of the NKp30 ligand binding domain	203:256	The oligomerization of the NKp30 ligand binding domain depends on the length of the C-terminal stalk region, but our structural knowledge of NKp30 oligomerization and its role in signal transduction remains limited.
32708305	7	47	theme	complex	986:992	arg1	structure					968:976	the crystal structure	956:976	the crystal structure of this complex	956:992	Furthermore, we characterized the interaction between NKp30 and its best-studied cognate ligand, B7-H6, with respect to glycosylation and oligomerization, and we solved the crystal structure of this complex with glycosylated NKp30, revealing a new glycosylation-induced mode of NKp30 dimerization.
32708305	1	48	theme	human	119:123	arg1	NK					141:142	NK	141:142	NK	141:142	NKp30 is one of the main human natural killer (NK) cell activating receptors used in directed immunotherapy.
32708305	1	48	theme	human	119:123	arg1	killer					133:138	human natural killer	119:138	the main human natural killer (NK) cell activating receptors used in directed immunotherapy	110:200	NKp30 is one of the main human natural killer (NK) cell activating receptors used in directed immunotherapy.
32708305	5	49	theme	GnTI-	669:673	arg1	lines					680:684	HEK293S GnTI- cell lines	661:684	HEK293S GnTI- cell lines with simple N-glycans	661:706	Our results show that NKp30 forms oligomers when expressed in HEK293S GnTI- cell lines with simple N-glycans.
32708305	2	50	theme	binding	243:249	arg1	domain					251:256	the NKp30 ligand binding domain	226:256	the NKp30 ligand binding domain	226:256	The oligomerization of the NKp30 ligand binding domain depends on the length of the C-terminal stalk region, but our structural knowledge of NKp30 oligomerization and its role in signal transduction remains limited.
32708305	1	51	theme	natural	125:131	arg1	NK					141:142	NK	141:142	NK	141:142	NKp30 is one of the main human natural killer (NK) cell activating receptors used in directed immunotherapy.
32708305	1	51	theme	natural	125:131	arg1	killer					133:138	human natural killer	119:138	the main human natural killer (NK) cell activating receptors used in directed immunotherapy	110:200	NKp30 is one of the main human natural killer (NK) cell activating receptors used in directed immunotherapy.
32708305	2	52	theme	ligand	236:241	arg1	domain					251:256	the NKp30 ligand binding domain	226:256	the NKp30 ligand binding domain	226:256	The oligomerization of the NKp30 ligand binding domain depends on the length of the C-terminal stalk region, but our structural knowledge of NKp30 oligomerization and its role in signal transduction remains limited.
32708305	1	53	theme	killer	133:138	arg1	receptors					161:169	the main human natural killer (NK) cell activating receptors	110:169	the main human natural killer (NK) cell activating receptors used in directed immunotherapy	110:200	NKp30 is one of the main human natural killer (NK) cell activating receptors used in directed immunotherapy.
32708305	9	54	theme	targeted	1425:1432	arg1	immunotherapeutics					1434:1451	novel NK cell-based targeted immunotherapeutics	1405:1451	novel NK cell-based targeted immunotherapeutics	1405:1451	This furthers our understanding of the molecular mechanisms involved in NK cell activation, which is crucial for the successful design of novel NK cell-based targeted immunotherapeutics.
32708305	8	55	theme	new	1114:1116	arg1	insights					1118:1125	new insights	1114:1125	new insights into the structural basis of NKp30 oligomerization	1114:1176	Overall, this study provides new insights into the structural basis of NKp30 oligomerization and explains how the stalk region and glycosylation of NKp30 affect its ligand affinity.
32708305	9	56	theme	successful	1384:1393	arg1	design					1395:1400	the successful design	1380:1400	the successful design of novel NK cell-based targeted immunotherapeutics	1380:1451	This furthers our understanding of the molecular mechanisms involved in NK cell activation, which is crucial for the successful design of novel NK cell-based targeted immunotherapeutics.
32708305	8	57	theme	structural	1136:1145	arg1	basis					1147:1151	the structural basis	1132:1151	the structural basis of NKp30 oligomerization	1132:1176	Overall, this study provides new insights into the structural basis of NKp30 oligomerization and explains how the stalk region and glycosylation of NKp30 affect its ligand affinity.
32862162	7	0	dep	agar	820:823	arg1	iii					800:802	iii	800:802	iii	800:802	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	15	1	theme	SPCA	1938:1941	arg1	employment					1924:1933	employment	1924:1933	employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration	1924:2027	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	15	2	dep	available	1880:1888	arg1	iv					1866:1867	iv	1866:1867	iv	1866:1867	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	12	3	dep	Conclusion	1368:1377	arg1	indicates					1390:1398	indicates	1390:1398	indicates that SPCA and MHA are equally effective as CBA, when enumerating of M. abscessus complex organisms	1390:1497	Conclusion This study indicates that SPCA and MHA are equally effective as CBA, when enumerating of M. abscessus complex organisms.
32862162	9	4	theme	colony	1042:1047	arg1	diameter					1049:1056	the mean colony diameter	1033:1056	the mean colony diameter on all other media	1033:1075	The growth was most profuse on SPCA, with a mean colony diameter of 3 mm, whereas the mean colony diameter on all other media was 1 mm.
32862162	9	4	theme	colony	1042:1047	arg1	mm					1083:1084	1 mm	1081:1084	1 mm	1081:1084	The growth was most profuse on SPCA, with a mean colony diameter of 3 mm, whereas the mean colony diameter on all other media was 1 mm.
32862162	1	5	contain	have	273:276	arg1	formulations					182:193	egg-based formulations	172:193	egg-based formulations (Lowenstein-Jensen medium)	172:220	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	1	5	contain	have	273:276	arg1	medium					214:219	Lowenstein-Jensen medium	196:219	Lowenstein-Jensen medium	196:219	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	1	5	contain	have	273:276	arg1	media					233:237	defined media	225:237	defined media (Middlebrook formulations)	225:264	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	1	5	contain	have	273:276	arg2	disadvantages					278:290	disadvantages	278:290	disadvantages of composition complexity, availability, and cost	278:340	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	1	5	contain	have	273:276	arg1	formulations					252:263	Middlebrook formulations	240:263	Middlebrook formulations	240:263	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	1	6	theme	egg-based	172:180	arg1	formulations					182:193	egg-based formulations	172:193	egg-based formulations (Lowenstein-Jensen medium)	172:220	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	1	6	theme	egg-based	172:180	arg1	medium					214:219	Lowenstein-Jensen medium	196:219	Lowenstein-Jensen medium	196:219	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	12	7	theme	complex	1481:1487	arg1	organisms					1489:1497	M. abscessus complex organisms	1468:1497	M. abscessus complex organisms	1468:1497	Conclusion This study indicates that SPCA and MHA are equally effective as CBA, when enumerating of M. abscessus complex organisms.
32862162	13	8	theme	TSA	1514:1516	arg1	Employment					1500:1509	Employment	1500:1509	Employment of TSA	1500:1516	Employment of TSA gave significantly lower counts than CBA (P = 0.01) and therefore should not be employed when enumerating these organisms.
32862162	7	9	theme	tryptone	769:776	arg1	TSA					789:791	TSA	789:791	TSA	789:791	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	7	9	theme	tryptone	769:776	arg1	agar					783:786	(ii) tryptone soya agar	764:786	(ii) tryptone soya agar (TSA)	764:792	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	9	10	theme	other	1065:1069	arg1	media					1071:1075	all other media	1061:1075	all other media	1061:1075	The growth was most profuse on SPCA, with a mean colony diameter of 3 mm, whereas the mean colony diameter on all other media was 1 mm.
32862162	4	11	dep	subsp	585:589	arg1	massiliense					559:569	massiliense	559:569	massiliense	559:569	massiliense, M. abscessus subsp.
32862162	15	12	theme	organisms	1996:2004	arg1	culture					1964:1970	the nonselective culture	1947:1970	the nonselective culture of M. abscessus complex organisms, including enumeration	1947:2027	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	15	13	dep	simple	1810:1815	arg1	ii					1803:1804	ii	1803:1804	ii	1803:1804	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	15	14	theme	abscessus	1978:1986	arg1	organisms					1996:2004	M. abscessus complex organisms	1975:2004	M. abscessus complex organisms	1975:2004	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	15	14	theme	abscessus	1978:1986	arg1	enumeration					2017:2027	enumeration	2017:2027	enumeration	2017:2027	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	3	15	dep	subsp	552:556	arg1	Methods					531:537	Methods	531:537	Methods	531:537	Methods M. abscessus subsp.
32862162	12	16	theme	abscessus	1471:1479	arg1	organisms					1489:1497	M. abscessus complex organisms	1468:1497	M. abscessus complex organisms	1468:1497	Conclusion This study indicates that SPCA and MHA are equally effective as CBA, when enumerating of M. abscessus complex organisms.
32862162	2	17	theme	abscessus	486:494	arg1	organisms					504:512	Mycobacterium abscessus complex organisms	472:512	Mycobacterium abscessus complex organisms	472:512	This study quantitatively compared three non-selective, non-blood based basal agars with Columbia blood agar (CBA), to enumerate Mycobacterium abscessus complex organisms in pure culture.
32862162	0	18	theme	Mycobacterium	57:69	arg1	complex					81:87	the Mycobacterium abscessus complex	53:87	the Mycobacterium abscessus complex	53:87	Comparison of four agar media for the enumeration of the Mycobacterium abscessus complex.
32862162	7	19	theme	each	662:665	arg1	Inocula					651:657	Inocula	651:657	Inocula of each of these	651:674	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	10	20	theme	significant	1230:1240	arg1	difference					1242:1251	a statistically significant difference	1214:1251	a statistically significant difference between CBA and TSA	1214:1271	Statistically, there was no significant difference in counts when comparing CBA with SPCA or MHA (P > 0.05), whereas there was a statistically significant difference between CBA and TSA (P = 0.01).
32862162	0	21	theme	complex	81:87	arg1	enumeration					38:48	the enumeration	34:48	the enumeration of the Mycobacterium abscessus complex	34:87	Comparison of four agar media for the enumeration of the Mycobacterium abscessus complex.
32862162	1	22	theme	mycobacteria	139:150	arg1	culture					113:119	Background Traditional culture	90:119	Background Traditional culture of nontuberculous mycobacteria (NTMs)	90:157	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	2	23	theme	pure	517:520	arg1	culture					522:528	pure culture	517:528	pure culture	517:528	This study quantitatively compared three non-selective, non-blood based basal agars with Columbia blood agar (CBA), to enumerate Mycobacterium abscessus complex organisms in pure culture.
32862162	2	24	theme	based	409:413	arg1	agars					421:425	three non-selective, non-blood based basal agars	378:425	three non-selective, non-blood based basal agars	378:425	This study quantitatively compared three non-selective, non-blood based basal agars with Columbia blood agar (CBA), to enumerate Mycobacterium abscessus complex organisms in pure culture.
32862162	15	25	dep	advantages	1722:1731	arg1	addition					1704:1711	addition	1704:1711	addition	1704:1711	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	11	26	theme	significant	1312:1322	arg1	difference					1324:1333	no statistically significant difference	1295:1333	no statistically significant difference between SPCA and MHA	1295:1354	There was no statistically significant difference between SPCA and MHA (P = 0.53).
32862162	2	27	theme	Columbia	432:439	arg1	CBA					453:455	CBA	453:455	CBA	453:455	This study quantitatively compared three non-selective, non-blood based basal agars with Columbia blood agar (CBA), to enumerate Mycobacterium abscessus complex organisms in pure culture.
32862162	2	27	theme	Columbia	432:439	arg1	agar					447:450	Columbia blood agar	432:450	Columbia blood agar (CBA)	432:456	This study quantitatively compared three non-selective, non-blood based basal agars with Columbia blood agar (CBA), to enumerate Mycobacterium abscessus complex organisms in pure culture.
32862162	1	28	theme	Traditional	101:111	arg1	culture					113:119	Background Traditional culture	90:119	Background Traditional culture of nontuberculous mycobacteria (NTMs)	90:157	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	10	29	theme	=	1276:1276	arg1	P					1274:1274	P	1274:1274	P = 0.01	1274:1281	Statistically, there was no significant difference in counts when comparing CBA with SPCA or MHA (P > 0.05), whereas there was a statistically significant difference between CBA and TSA (P = 0.01).
32862162	0	30	theme	media	24:28	arg1	Comparison					0:9	Comparison	0:9	Comparison of four agar media for the enumeration of the Mycobacterium abscessus complex.	0:88	Comparison of four agar media for the enumeration of the Mycobacterium abscessus complex.
32862162	1	31	theme	complexity	307:316	arg1	disadvantages					278:290	disadvantages	278:290	disadvantages of composition complexity, availability, and cost	278:340	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	5	32	dep	subsp	619:623	arg1	bolletii					592:599	bolletii	592:599	bolletii	592:599	bolletii, and M. abscessus subsp.
32862162	5	32	dep	subsp	619:623	arg1	M.					606:607	M.	606:607	M.	606:607	bolletii, and M. abscessus subsp.
32862162	9	33	from	profuse	971:977	arg1	SPCA					982:985	SPCA	982:985	SPCA	982:985	The growth was most profuse on SPCA, with a mean colony diameter of 3 mm, whereas the mean colony diameter on all other media was 1 mm.
32862162	7	34	theme	plate	739:743	arg1	agar					751:754	(i) standard plate count agar	726:754	(i) standard plate count agar (SPCA)	726:761	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	7	34	theme	plate	739:743	arg1	SPCA					757:760	SPCA	757:760	SPCA	757:760	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	14	35	theme	media	1685:1689	arg1	growth					1671:1676	the most profuse growth	1654:1676	the most profuse growth of all media examined	1654:1698	SPCA yielded the most profuse growth of all media examined.
32862162	9	36	theme	colony	1000:1005	arg1	diameter					1007:1014	a mean colony diameter	993:1014	a mean colony diameter of 3 mm	993:1022	The growth was most profuse on SPCA, with a mean colony diameter of 3 mm, whereas the mean colony diameter on all other media was 1 mm.
32862162	1	37	theme	defined	225:231	arg1	media					233:237	defined media	225:237	defined media (Middlebrook formulations)	225:264	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	1	37	theme	defined	225:231	arg1	formulations					252:263	Middlebrook formulations	240:263	Middlebrook formulations	240:263	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	3	38	theme	M.	539:540	arg1	subsp					552:556	M. abscessus subsp	539:556	M. abscessus subsp	539:556	Methods M. abscessus subsp.
32862162	10	39	dep	was	1210:1212	arg1	P					1274:1274	P	1274:1274	P = 0.01	1274:1281	Statistically, there was no significant difference in counts when comparing CBA with SPCA or MHA (P > 0.05), whereas there was a statistically significant difference between CBA and TSA (P = 0.01).
32862162	15	40	theme	nonselective	1951:1962	arg1	culture					1964:1970	the nonselective culture	1947:1970	the nonselective culture of M. abscessus complex organisms, including enumeration	1947:2027	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	15	41	theme	medium	1782:1787	arg1	constituent					1789:1799	a medium constituent	1780:1799	a medium constituent	1780:1799	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	15	41	theme	medium	1782:1787	arg1	i					1756:1756	i	1756:1756	i	1756:1756	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	15	41	theme	medium	1782:1787	arg1	blood					1771:1775	blood	1771:1775	blood	1771:1775	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	9	42	theme	mm	1021:1022	arg1	diameter					1007:1014	a mean colony diameter	993:1014	a mean colony diameter of 3 mm	993:1022	The growth was most profuse on SPCA, with a mean colony diameter of 3 mm, whereas the mean colony diameter on all other media was 1 mm.
32862162	4	43	theme	abscessus	575:583	arg1	subsp					585:589	M. abscessus subsp	572:589	M. abscessus subsp	572:589	massiliense, M. abscessus subsp.
32862162	13	44	theme	lower	1537:1541	arg1	counts					1543:1548	significantly lower counts	1523:1548	significantly lower counts	1523:1548	Employment of TSA gave significantly lower counts than CBA (P = 0.01) and therefore should not be employed when enumerating these organisms.
32862162	3	45	theme	abscessus	542:550	arg1	subsp					552:556	M. abscessus subsp	539:556	M. abscessus subsp	539:556	Methods M. abscessus subsp.
32862162	7	46	theme	agar	704:707	arg1	media					709:713	three basal agar media	692:713	three basal agar media	692:713	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	14	47	theme	profuse	1663:1669	arg1	growth					1671:1676	the most profuse growth	1654:1676	the most profuse growth of all media examined	1654:1698	SPCA yielded the most profuse growth of all media examined.
32862162	8	48	theme	NTM	874:876	arg1	isolates					878:885	All NTM isolates	870:885	All NTM isolates of all subspecies	870:903	Results All NTM isolates of all subspecies grew successfully on all four media examined.
32862162	9	49	theme	mean	1037:1040	arg1	diameter					1049:1056	the mean colony diameter	1033:1056	the mean colony diameter on all other media	1033:1075	The growth was most profuse on SPCA, with a mean colony diameter of 3 mm, whereas the mean colony diameter on all other media was 1 mm.
32862162	9	49	theme	mean	1037:1040	arg1	mm					1083:1084	1 mm	1081:1084	1 mm	1081:1084	The growth was most profuse on SPCA, with a mean colony diameter of 3 mm, whereas the mean colony diameter on all other media was 1 mm.
32862162	14	50	theme	most	1658:1661	arg1	growth					1671:1676	the most profuse growth	1654:1676	the most profuse growth of all media examined	1654:1698	SPCA yielded the most profuse growth of all media examined.
32862162	7	51	dep	agar	751:754	arg1	i					727:727	i	727:727	i	727:727	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	12	52	theme	organisms	1489:1497	arg1	enumerating					1453:1463	enumerating	1453:1463	enumerating	1453:1463	Conclusion This study indicates that SPCA and MHA are equally effective as CBA, when enumerating of M. abscessus complex organisms.
32862162	1	53	theme	availability	319:330	arg1	disadvantages					278:290	disadvantages	278:290	disadvantages of composition complexity, availability, and cost	278:340	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	8	54	theme	subspecies	894:903	arg1	isolates					878:885	All NTM isolates	870:885	All NTM isolates of all subspecies	870:903	Results All NTM isolates of all subspecies grew successfully on all four media examined.
32862162	15	55	dep	cheap	1854:1858	arg1	iii					1835:1837	iii	1835:1837	iii	1835:1837	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	7	56	theme	soya	778:781	arg1	TSA					789:791	TSA	789:791	TSA	789:791	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	7	56	theme	soya	778:781	arg1	agar					783:786	(ii) tryptone soya agar	764:786	(ii) tryptone soya agar (TSA)	764:792	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	7	57	theme	basal	698:702	arg1	media					709:713	three basal agar media	692:713	three basal agar media	692:713	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	1	58	theme	nontuberculous	124:137	arg1	NTMs					153:156	NTMs	153:156	NTMs	153:156	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	1	58	theme	nontuberculous	124:137	arg1	mycobacteria					139:150	nontuberculous mycobacteria	124:150	nontuberculous mycobacteria (NTMs)	124:157	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	9	59	from	diameter	1049:1056	arg1	media					1071:1075	all other media	1061:1075	all other media	1061:1075	The growth was most profuse on SPCA, with a mean colony diameter of 3 mm, whereas the mean colony diameter on all other media was 1 mm.
32862162	15	60	theme	complex	1988:1994	arg1	organisms					1996:2004	M. abscessus complex organisms	1975:2004	M. abscessus complex organisms	1975:2004	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	15	60	theme	complex	1988:1994	arg1	enumeration					2017:2027	enumeration	2017:2027	enumeration	2017:2027	In addition to these advantages, given that SPCA does (i) not require blood as a medium constituent, (ii) is simple to reconstitute, (iii) is relatively cheap, and (iv) is widely available commercially, this study endorses employment of SPCA for the nonselective culture of M. abscessus complex organisms, including enumeration.
32862162	12	61	theme	M.	1468:1469	arg1	organisms					1489:1497	M. abscessus complex organisms	1468:1497	M. abscessus complex organisms	1468:1497	Conclusion This study indicates that SPCA and MHA are equally effective as CBA, when enumerating of M. abscessus complex organisms.
32862162	2	62	theme	complex	496:502	arg1	organisms					504:512	Mycobacterium abscessus complex organisms	472:512	Mycobacterium abscessus complex organisms	472:512	This study quantitatively compared three non-selective, non-blood based basal agars with Columbia blood agar (CBA), to enumerate Mycobacterium abscessus complex organisms in pure culture.
32862162	7	63	from	counts	847:852	arg1	CBA					857:859	CBA	857:859	CBA	857:859	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	0	64	theme	abscessus	71:79	arg1	complex					81:87	the Mycobacterium abscessus complex	53:87	the Mycobacterium abscessus complex	53:87	Comparison of four agar media for the enumeration of the Mycobacterium abscessus complex.
32862162	1	65	theme	cost	337:340	arg1	disadvantages					278:290	disadvantages	278:290	disadvantages of composition complexity, availability, and cost	278:340	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	10	66	dep	=	1276:1276	arg1	0.01					1278:1281	0.01	1278:1281	0.01	1278:1281	Statistically, there was no significant difference in counts when comparing CBA with SPCA or MHA (P > 0.05), whereas there was a statistically significant difference between CBA and TSA (P = 0.01).
32862162	10	67	theme	significant	1115:1125	arg1	difference					1127:1136	no significant difference	1112:1136	no significant difference	1112:1136	Statistically, there was no significant difference in counts when comparing CBA with SPCA or MHA (P > 0.05), whereas there was a statistically significant difference between CBA and TSA (P = 0.01).
32862162	5	68	theme	abscessus	609:617	arg1	subsp					619:623	abscessus subsp	609:623	abscessus subsp	609:623	bolletii, and M. abscessus subsp.
32862162	2	69	theme	non-selective	384:396	arg1	agars					421:425	three non-selective, non-blood based basal agars	378:425	three non-selective, non-blood based basal agars	378:425	This study quantitatively compared three non-selective, non-blood based basal agars with Columbia blood agar (CBA), to enumerate Mycobacterium abscessus complex organisms in pure culture.
32862162	0	70	theme	agar	19:22	arg1	media					24:28	four agar media	14:28	four agar media	14:28	Comparison of four agar media for the enumeration of the Mycobacterium abscessus complex.
32862162	1	71	theme	Background	90:99	arg1	culture					113:119	Background Traditional culture	90:119	Background Traditional culture of nontuberculous mycobacteria (NTMs)	90:157	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	2	72	theme	blood	441:445	arg1	CBA					453:455	CBA	453:455	CBA	453:455	This study quantitatively compared three non-selective, non-blood based basal agars with Columbia blood agar (CBA), to enumerate Mycobacterium abscessus complex organisms in pure culture.
32862162	2	72	theme	blood	441:445	arg1	agar					447:450	Columbia blood agar	432:450	Columbia blood agar (CBA)	432:456	This study quantitatively compared three non-selective, non-blood based basal agars with Columbia blood agar (CBA), to enumerate Mycobacterium abscessus complex organisms in pure culture.
32862162	4	73	theme	M.	572:573	arg1	subsp					585:589	M. abscessus subsp	572:589	M. abscessus subsp	572:589	massiliense, M. abscessus subsp.
32862162	8	74	dep	Results	862:868	arg1	grew					905:908	grew	905:908	grew successfully on all four media examined	905:948	Results All NTM isolates of all subspecies grew successfully on all four media examined.
32862162	1	75	theme	composition	295:305	arg1	complexity					307:316	composition complexity	295:316	composition complexity	295:316	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	7	76	theme	Mueller-Hinton	805:818	arg1	MHA					826:828	MHA	826:828	MHA	826:828	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	7	76	theme	Mueller-Hinton	805:818	arg1	agar					820:823	(iii) Mueller-Hinton agar	799:823	(iii) Mueller-Hinton agar (MHA)	799:829	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	7	77	dep	agar	783:786	arg1	ii					765:766	ii	765:766	ii	765:766	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	2	78	theme	basal	415:419	arg1	agars					421:425	three non-selective, non-blood based basal agars	378:425	three non-selective, non-blood based basal agars	378:425	This study quantitatively compared three non-selective, non-blood based basal agars with Columbia blood agar (CBA), to enumerate Mycobacterium abscessus complex organisms in pure culture.
32862162	9	79	theme	mean	995:998	arg1	diameter					1007:1014	a mean colony diameter	993:1014	a mean colony diameter of 3 mm	993:1022	The growth was most profuse on SPCA, with a mean colony diameter of 3 mm, whereas the mean colony diameter on all other media was 1 mm.
32862162	9	80	with	profuse	971:977	arg1	diameter					1007:1014	a mean colony diameter	993:1014	a mean colony diameter of 3 mm	993:1022	The growth was most profuse on SPCA, with a mean colony diameter of 3 mm, whereas the mean colony diameter on all other media was 1 mm.
32862162	7	81	theme	count	745:749	arg1	agar					751:754	(i) standard plate count agar	726:754	(i) standard plate count agar (SPCA)	726:761	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	7	81	theme	count	745:749	arg1	SPCA					757:760	SPCA	757:760	SPCA	757:760	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	7	82	dep	media	709:713	arg1	including					716:724	including	716:724	including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA)	716:829	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	2	83	dep	non-selective	384:396	arg1	non-blood					399:407	non-blood	399:407	non-blood	399:407	This study quantitatively compared three non-selective, non-blood based basal agars with Columbia blood agar (CBA), to enumerate Mycobacterium abscessus complex organisms in pure culture.
32862162	10	84	theme	P	1185:1185	arg1	MHA					1180:1182	MHA	1180:1182	MHA (P > 0.05)	1180:1193	Statistically, there was no significant difference in counts when comparing CBA with SPCA or MHA (P > 0.05), whereas there was a statistically significant difference between CBA and TSA (P = 0.01).
32862162	10	84	theme	P	1185:1185	arg1	>					1187:1187	P > 0.05	1185:1192	P > 0.05	1185:1192	Statistically, there was no significant difference in counts when comparing CBA with SPCA or MHA (P > 0.05), whereas there was a statistically significant difference between CBA and TSA (P = 0.01).
32862162	7	85	theme	standard	730:737	arg1	agar					751:754	(i) standard plate count agar	726:754	(i) standard plate count agar (SPCA)	726:761	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	7	85	theme	standard	730:737	arg1	SPCA					757:760	SPCA	757:760	SPCA	757:760	Inocula of each of these were counted on three basal agar media, including (i) standard plate count agar (SPCA), (ii) tryptone soya agar (TSA), and (iii) Mueller-Hinton agar (MHA) and compared to counts on CBA.
32862162	1	86	theme	Middlebrook	240:250	arg1	media					233:237	defined media	225:237	defined media (Middlebrook formulations)	225:264	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
32862162	1	86	theme	Middlebrook	240:250	arg1	formulations					252:263	Middlebrook formulations	240:263	Middlebrook formulations	240:263	Background Traditional culture of nontuberculous mycobacteria (NTMs) has involved egg-based formulations (Lowenstein-Jensen medium) or defined media (Middlebrook formulations), which have disadvantages of composition complexity, availability, and cost.
33971228	7	0	theme	activated	1030:1038	arg1	carbon					1040:1045	activated carbon	1030:1045	activated carbon (AC)	1030:1050	The adsorption capacity obtained for C-PC, C-AC, activated carbon (AC) and chitosan (CH) using Langmuir isotherm model are 3333.33 mg/g, 909.90 mg/g, 909.09 mg/g and 833.33 mg/g, respectively.
33971228	7	0	theme	activated	1030:1038	arg1	AC					1048:1049	AC	1048:1049	AC	1048:1049	The adsorption capacity obtained for C-PC, C-AC, activated carbon (AC) and chitosan (CH) using Langmuir isotherm model are 3333.33 mg/g, 909.90 mg/g, 909.09 mg/g and 833.33 mg/g, respectively.
33971228	1	1	theme	chitosan/porous	156:170	arg1	C-PC					190:193	chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition	156:279	chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition	156:279	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	2	2	theme	adsorption	377:386	arg1	efficiency					388:397	adsorption efficiency	377:397	adsorption efficiency of C-PC	377:405	For comparison of adsorption efficiency of C-PC, chitosan-activated carbon composite (C-AC) was also prepared in 1% acetic acid.
33971228	1	3	theme	carbon	172:177	arg1	C-PC					190:193	chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition	156:279	chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition	156:279	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	0	4	theme	imidazolium	107:117	arg1	bromide					119:125	1-allyl-3-methyl imidazolium bromide	90:125	1-allyl-3-methyl imidazolium bromide ionic liquid	90:138	Enhanced adsorption of acid Blue-25 dye onto chitosan/porous carbon composite modified in 1-allyl-3-methyl imidazolium bromide ionic liquid.
33971228	10	5	from	possibility	1419:1429	arg1	process					1474:1480	the adsorption process	1459:1480	the adsorption process	1459:1480	The kinetics of the adsorption fitted into pseudo-second order indicating the possibility of chemical interactions in the adsorption process.
33971228	7	6	theme	adsorption	985:994	arg1	capacity					996:1003	The adsorption capacity	981:1003	The adsorption capacity obtained for C-PC, C-AC, activated carbon (AC) and chitosan (CH) using Langmuir isotherm model	981:1098	The adsorption capacity obtained for C-PC, C-AC, activated carbon (AC) and chitosan (CH) using Langmuir isotherm model are 3333.33 mg/g, 909.90 mg/g, 909.09 mg/g and 833.33 mg/g, respectively.
33971228	7	6	theme	adsorption	985:994	arg1	mg/g					1112:1115	3333.33 mg/g	1104:1115	3333.33 mg/g	1104:1115	The adsorption capacity obtained for C-PC, C-AC, activated carbon (AC) and chitosan (CH) using Langmuir isotherm model are 3333.33 mg/g, 909.90 mg/g, 909.09 mg/g and 833.33 mg/g, respectively.
33971228	5	7	theme	active	882:887	arg1	sites					889:893	the main active sites	873:893	the main active sites for AB-25 dye uptake	873:914	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	5	7	theme	active	882:887	arg1	group					855:859	the hydroxyl and amino group	832:859	group	855:859	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	5	8	theme	main	877:880	arg1	sites					889:893	the main active sites	873:893	the main active sites for AB-25 dye uptake	873:914	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	5	8	theme	main	877:880	arg1	group					855:859	the hydroxyl and amino group	832:859	group	855:859	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	1	9	theme	airtight	262:269	arg1	condition					271:279	airtight condition	262:279	airtight condition	262:279	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	0	10	theme	1-allyl-3-methyl	90:105	arg1	bromide					119:125	1-allyl-3-methyl imidazolium bromide	90:125	1-allyl-3-methyl imidazolium bromide ionic liquid	90:138	Enhanced adsorption of acid Blue-25 dye onto chitosan/porous carbon composite modified in 1-allyl-3-methyl imidazolium bromide ionic liquid.
33971228	10	11	from	interactions	1443:1454	arg1	process					1474:1480	the adsorption process	1459:1480	the adsorption process	1459:1480	The kinetics of the adsorption fitted into pseudo-second order indicating the possibility of chemical interactions in the adsorption process.
33971228	10	12	theme	interactions	1443:1454	arg1	possibility					1419:1429	the possibility	1415:1429	the possibility of chemical interactions in the adsorption process	1415:1480	The kinetics of the adsorption fitted into pseudo-second order indicating the possibility of chemical interactions in the adsorption process.
33971228	7	13	theme	isotherm	1085:1092	arg1	model					1094:1098	Langmuir isotherm model	1076:1098	Langmuir isotherm model	1076:1098	The adsorption capacity obtained for C-PC, C-AC, activated carbon (AC) and chitosan (CH) using Langmuir isotherm model are 3333.33 mg/g, 909.90 mg/g, 909.09 mg/g and 833.33 mg/g, respectively.
33971228	5	14	theme	C-PC	805:808	arg1	surfaces					819:826	the C-PC and C-AC surfaces	801:826	surfaces	819:826	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	1	15	theme	aqueous	343:349	arg1	medium					351:356	aqueous medium	343:356	aqueous medium	343:356	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	5	16	theme	mesopores	788:796	arg1	domination					774:783	the domination	770:783	the domination of mesopores on the C-PC and C-AC surfaces	770:826	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	1	17	theme	composite	179:187	arg1	C-PC					190:193	chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition	156:279	chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition	156:279	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	2	18	theme	acetic	475:480	arg1	acid					482:485	1% acetic acid	472:485	1% acetic acid	472:485	For comparison of adsorption efficiency of C-PC, chitosan-activated carbon composite (C-AC) was also prepared in 1% acetic acid.
33971228	5	19	from	group	855:859	arg1	C-PC					864:867	C-PC	864:867	C-PC	864:867	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	5	20	theme	AB-25	899:903	arg1	uptake					909:914	AB-25 dye uptake	899:914	AB-25 dye uptake	899:914	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	1	21	from	medium	351:356	arg1	removal					302:308	the removal	298:308	the removal of Acid Blue-25 dye (AB-25) from aqueous medium	298:356	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	10	22	theme	adsorption	1361:1370	arg1	kinetics					1345:1352	The kinetics	1341:1352	The kinetics of the adsorption	1341:1370	The kinetics of the adsorption fitted into pseudo-second order indicating the possibility of chemical interactions in the adsorption process.
33971228	4	23	theme	stone-like	681:690	arg1	materials					692:700	irregular shaped stone-like materials	664:700	irregular shaped stone-like materials	664:700	The micrograph of C-PC revealed cavities and slightly rough surfaces dominated with similar sized and irregular shaped stone-like materials which differ from the precursors' micrograph.
33971228	5	24	from	domination	774:783	arg1	surfaces					819:826	the C-PC and C-AC surfaces	801:826	surfaces	819:826	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	5	25	theme	C-AC	814:817	arg1	surfaces					819:826	the C-PC and C-AC surfaces	801:826	surfaces	819:826	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	0	26	theme	Enhanced	0:7	arg1	adsorption					9:18	Enhanced adsorption	0:18	Enhanced adsorption of acid Blue-25 dye onto chitosan/porous carbon composite	0:76	Enhanced adsorption of acid Blue-25 dye onto chitosan/porous carbon composite modified in 1-allyl-3-methyl imidazolium bromide ionic liquid.
33971228	10	27	theme	chemical	1434:1441	arg1	interactions					1443:1454	chemical interactions	1434:1454	chemical interactions in the adsorption process	1434:1480	The kinetics of the adsorption fitted into pseudo-second order indicating the possibility of chemical interactions in the adsorption process.
33971228	6	28	from	pH	958:959	arg1	C-AC					967:970	C-AC	967:970	C-AC at pH 4	967:978	The dye was better adsorbed onto C-PC at pH 2 and C-AC at pH 4.
33971228	6	28	from	pH	958:959	arg1	C-PC					950:953	C-PC	950:953	C-PC at pH 2	950:961	The dye was better adsorbed onto C-PC at pH 2 and C-AC at pH 4.
33971228	4	29	theme	shaped	674:679	arg1	materials					692:700	irregular shaped stone-like materials	664:700	irregular shaped stone-like materials	664:700	The micrograph of C-PC revealed cavities and slightly rough surfaces dominated with similar sized and irregular shaped stone-like materials which differ from the precursors' micrograph.
33971228	8	30	theme	dye	1274:1276	arg1	adsorption					1256:1265	adsorption	1256:1265	adsorption of the dye onto C-PC, AC and CH	1256:1297	The experimental data are well described by Langmuir and Fruendlich isotherms for adsorption of the dye onto C-PC, AC and CH.
33971228	0	31	theme	acid	23:26	arg1	dye					36:38	acid Blue-25 dye	23:38	acid Blue-25 dye	23:38	Enhanced adsorption of acid Blue-25 dye onto chitosan/porous carbon composite modified in 1-allyl-3-methyl imidazolium bromide ionic liquid.
33971228	2	32	theme	chitosan-activated	408:425	arg1	composite					434:442	chitosan-activated carbon composite	408:442	chitosan-activated carbon composite (C-AC)	408:449	For comparison of adsorption efficiency of C-PC, chitosan-activated carbon composite (C-AC) was also prepared in 1% acetic acid.
33971228	2	32	theme	chitosan-activated	408:425	arg1	C-AC					445:448	C-AC	445:448	C-AC	445:448	For comparison of adsorption efficiency of C-PC, chitosan-activated carbon composite (C-AC) was also prepared in 1% acetic acid.
33971228	0	33	theme	liquid	133:138	arg1	bromide					119:125	1-allyl-3-methyl imidazolium bromide	90:125	1-allyl-3-methyl imidazolium bromide ionic liquid	90:138	Enhanced adsorption of acid Blue-25 dye onto chitosan/porous carbon composite modified in 1-allyl-3-methyl imidazolium bromide ionic liquid.
33971228	5	34	theme	hydroxyl	836:843	arg1	sites					889:893	the main active sites	873:893	the main active sites for AB-25 dye uptake	873:914	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	5	34	theme	hydroxyl	836:843	arg1	group					855:859	the hydroxyl and amino group	832:859	group	855:859	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	2	35	theme	C-PC	402:405	arg1	efficiency					388:397	adsorption efficiency	377:397	adsorption efficiency of C-PC	377:405	For comparison of adsorption efficiency of C-PC, chitosan-activated carbon composite (C-AC) was also prepared in 1% acetic acid.
33971228	0	36	theme	dye	36:38	arg1	adsorption					9:18	Enhanced adsorption	0:18	Enhanced adsorption of acid Blue-25 dye onto chitosan/porous carbon composite	0:76	Enhanced adsorption of acid Blue-25 dye onto chitosan/porous carbon composite modified in 1-allyl-3-methyl imidazolium bromide ionic liquid.
33971228	5	37	theme	amino	849:853	arg1	sites					889:893	the main active sites	873:893	the main active sites for AB-25 dye uptake	873:914	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	5	37	theme	amino	849:853	arg1	group					855:859	the hydroxyl and amino group	832:859	group	855:859	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	4	38	theme	C-PC	580:583	arg1	micrograph					566:575	The micrograph	562:575	The micrograph of C-PC	562:583	The micrograph of C-PC revealed cavities and slightly rough surfaces dominated with similar sized and irregular shaped stone-like materials which differ from the precursors' micrograph.
33971228	1	39	dep	C-PC	190:193	arg1	modified					196:203	modified	196:203	modified in 1-Allyl-3-methyl imidazolium bromide [AMIM	196:249	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	10	40	theme	adsorption	1463:1472	arg1	process					1474:1480	the adsorption process	1459:1480	the adsorption process	1459:1480	The kinetics of the adsorption fitted into pseudo-second order indicating the possibility of chemical interactions in the adsorption process.
33971228	1	41	theme	1-Allyl-3-methyl	208:223	arg1	[AMIM					245:249	1-Allyl-3-methyl imidazolium bromide [AMIM	208:249	1-Allyl-3-methyl imidazolium bromide [AMIM	208:249	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	0	42	theme	Blue-25	28:34	arg1	dye					36:38	acid Blue-25 dye	23:38	acid Blue-25 dye	23:38	Enhanced adsorption of acid Blue-25 dye onto chitosan/porous carbon composite modified in 1-allyl-3-methyl imidazolium bromide ionic liquid.
33971228	2	43	theme	carbon	427:432	arg1	composite					434:442	chitosan-activated carbon composite	408:442	chitosan-activated carbon composite (C-AC)	408:449	For comparison of adsorption efficiency of C-PC, chitosan-activated carbon composite (C-AC) was also prepared in 1% acetic acid.
33971228	2	43	theme	carbon	427:432	arg1	C-AC					445:448	C-AC	445:448	C-AC	445:448	For comparison of adsorption efficiency of C-PC, chitosan-activated carbon composite (C-AC) was also prepared in 1% acetic acid.
33971228	10	44	from	process	1474:1480	arg1	possibility					1419:1429	the possibility	1415:1429	the possibility of chemical interactions in the adsorption process	1415:1480	The kinetics of the adsorption fitted into pseudo-second order indicating the possibility of chemical interactions in the adsorption process.
33971228	1	45	theme	imidazolium	225:235	arg1	[AMIM					245:249	1-Allyl-3-methyl imidazolium bromide [AMIM	208:249	1-Allyl-3-methyl imidazolium bromide [AMIM	208:249	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	0	46	theme	chitosan/porous	45:59	arg1	composite					68:76	chitosan/porous carbon composite	45:76	chitosan/porous carbon composite	45:76	Enhanced adsorption of acid Blue-25 dye onto chitosan/porous carbon composite modified in 1-allyl-3-methyl imidazolium bromide ionic liquid.
33971228	2	47	theme	1	472:472	arg1	%					473:473	%	473:473	%	473:473	For comparison of adsorption efficiency of C-PC, chitosan-activated carbon composite (C-AC) was also prepared in 1% acetic acid.
33971228	5	48	theme	BET	748:750	arg1	analysis					752:759	BET analysis	748:759	BET analysis	748:759	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	1	49	theme	Acid	313:316	arg1	AB-25					331:335	AB-25	331:335	AB-25	331:335	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	1	49	theme	Acid	313:316	arg1	dye					326:328	Acid Blue-25 dye	313:328	Acid Blue-25 dye (AB-25)	313:336	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	8	50	theme	Fruendlich	1231:1240	arg1	isotherms					1242:1250	Langmuir and Fruendlich isotherms	1218:1250	Langmuir and Fruendlich isotherms for adsorption of the dye onto C-PC, AC and CH	1218:1297	The experimental data are well described by Langmuir and Fruendlich isotherms for adsorption of the dye onto C-PC, AC and CH.
33971228	4	51	theme	similar	646:652	arg1	sized					654:658	similar sized	646:658	similar sized	646:658	The micrograph of C-PC revealed cavities and slightly rough surfaces dominated with similar sized and irregular shaped stone-like materials which differ from the precursors' micrograph.
33971228	1	52	theme	Blue-25	318:324	arg1	AB-25					331:335	AB-25	331:335	AB-25	331:335	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	1	52	theme	Blue-25	318:324	arg1	dye					326:328	Acid Blue-25 dye	313:328	Acid Blue-25 dye (AB-25)	313:336	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	5	53	theme	dye	905:907	arg1	uptake					909:914	AB-25 dye uptake	899:914	AB-25 dye uptake	899:914	BET analysis revealed the domination of mesopores on the C-PC and C-AC surfaces, as the hydroxyl and amino group on C-PC are the main active sites for AB-25 dye uptake.
33971228	8	54	theme	Langmuir	1218:1225	arg1	isotherms					1242:1250	Langmuir and Fruendlich isotherms	1218:1250	Langmuir and Fruendlich isotherms for adsorption of the dye onto C-PC, AC and CH	1218:1297	The experimental data are well described by Langmuir and Fruendlich isotherms for adsorption of the dye onto C-PC, AC and CH.
33971228	4	55	theme	irregular	664:672	arg1	materials					692:700	irregular shaped stone-like materials	664:700	irregular shaped stone-like materials	664:700	The micrograph of C-PC revealed cavities and slightly rough surfaces dominated with similar sized and irregular shaped stone-like materials which differ from the precursors' micrograph.
33971228	1	56	theme	bromide	237:243	arg1	[AMIM					245:249	1-Allyl-3-methyl imidazolium bromide [AMIM	208:249	1-Allyl-3-methyl imidazolium bromide [AMIM	208:249	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	8	57	theme	experimental	1178:1189	arg1	data					1191:1194	The experimental data	1174:1194	The experimental data	1174:1194	The experimental data are well described by Langmuir and Fruendlich isotherms for adsorption of the dye onto C-PC, AC and CH.
33971228	9	58	theme	Langmuir	1317:1324	arg1	isotherm					1326:1333	Langmuir isotherm	1317:1333	Langmuir isotherm only	1317:1338	C-AC fitted into Langmuir isotherm only.
33971228	2	59	theme	%	473:473	arg1	acid					482:485	1% acetic acid	472:485	1% acetic acid	472:485	For comparison of adsorption efficiency of C-PC, chitosan-activated carbon composite (C-AC) was also prepared in 1% acetic acid.
33971228	2	60	theme	efficiency	388:397	arg1	comparison					363:372	comparison	363:372	comparison of adsorption efficiency of C-PC	363:405	For comparison of adsorption efficiency of C-PC, chitosan-activated carbon composite (C-AC) was also prepared in 1% acetic acid.
33971228	6	61	from	pH	975:976	arg1	C-AC					967:970	C-AC	967:970	C-AC at pH 4	967:978	The dye was better adsorbed onto C-PC at pH 2 and C-AC at pH 4.
33971228	6	61	from	pH	975:976	arg1	C-PC					950:953	C-PC	950:953	C-PC at pH 2	950:961	The dye was better adsorbed onto C-PC at pH 2 and C-AC at pH 4.
33971228	7	62	theme	Langmuir	1076:1083	arg1	model					1094:1098	Langmuir isotherm model	1076:1098	Langmuir isotherm model	1076:1098	The adsorption capacity obtained for C-PC, C-AC, activated carbon (AC) and chitosan (CH) using Langmuir isotherm model are 3333.33 mg/g, 909.90 mg/g, 909.09 mg/g and 833.33 mg/g, respectively.
33971228	0	63	theme	carbon	61:66	arg1	composite					68:76	chitosan/porous carbon composite	45:76	chitosan/porous carbon composite	45:76	Enhanced adsorption of acid Blue-25 dye onto chitosan/porous carbon composite modified in 1-allyl-3-methyl imidazolium bromide ionic liquid.
33971228	1	64	theme	dye	326:328	arg1	removal					302:308	the removal	298:308	the removal of Acid Blue-25 dye (AB-25) from aqueous medium	298:356	In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium.
33971228	7	65	theme	mg/g	1125:1128	arg1	mg/g					1138:1141	909.90 mg/g, 909.09 mg/g and 833.33 mg/g	1118:1157	mg/g	1138:1141	The adsorption capacity obtained for C-PC, C-AC, activated carbon (AC) and chitosan (CH) using Langmuir isotherm model are 3333.33 mg/g, 909.90 mg/g, 909.09 mg/g and 833.33 mg/g, respectively.
33971228	7	65	theme	mg/g	1125:1128	arg1	mg/g					1112:1115	3333.33 mg/g	1104:1115	3333.33 mg/g	1104:1115	The adsorption capacity obtained for C-PC, C-AC, activated carbon (AC) and chitosan (CH) using Langmuir isotherm model are 3333.33 mg/g, 909.90 mg/g, 909.09 mg/g and 833.33 mg/g, respectively.
33971228	4	66	theme	rough	616:620	arg1	surfaces					622:629	slightly rough surfaces	607:629	slightly rough surfaces	607:629	The micrograph of C-PC revealed cavities and slightly rough surfaces dominated with similar sized and irregular shaped stone-like materials which differ from the precursors' micrograph.
33971228	10	67	theme	pseudo-second	1384:1396	arg1	order					1398:1402	pseudo-second order	1384:1402	pseudo-second order	1384:1402	The kinetics of the adsorption fitted into pseudo-second order indicating the possibility of chemical interactions in the adsorption process.
34547392	3	0	theme	various	369:375	arg1	drugs					377:381	various drugs	369:381	various drugs	369:381	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	3	1	theme	drug	491:494	arg1	release					496:502	the drug release	487:502	the drug release	487:502	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	4	2	from	applications	564:575	arg1	present					539:545	present	539:545	present	539:545	Since biomolecules will always be present in real clinical applications, media supplemented by albumin were also included.
34547392	5	3	theme	films	710:714	arg1	loading					695:701	convenient loading	684:701	convenient loading of the films by both hydrophilic and hydrophobic drugs	684:756	The amphiphilic character of lauroyl hyaluronan enabled convenient loading of the films by both hydrophilic and hydrophobic drugs.
34547392	7	4	theme	other	994:998	arg1	parameters					1000:1009	other parameters	994:1009	other parameters	994:1009	Hydrophilic diclofenac was released rapidly in all cases, while triclosan with medium hydrophobicity exhibited slower release sensitive to other parameters, reaching equilibrium values in the used experimental setup.
34547392	1	5	theme	safe	156:159	arg1	materials					179:187	safe and biodegradable materials	156:187	safe and biodegradable materials that seem promising for application in medicine	156:235	Lauroyl derivatives of hyaluronan are safe and biodegradable materials that seem promising for application in medicine.
34547392	1	5	theme	safe	156:159	arg1	derivatives					126:136	Lauroyl derivatives	118:136	Lauroyl derivatives of hyaluronan	118:150	Lauroyl derivatives of hyaluronan are safe and biodegradable materials that seem promising for application in medicine.
34547392	3	6	theme	hyaluronan	340:349	arg1	films					351:355	lauroyl hyaluronan films	332:355	lauroyl hyaluronan films loaded with various drugs	332:381	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	3	7	from	effects	399:405	arg1	release					496:502	the drug release	487:502	the drug release	487:502	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	5	8	theme	lauroyl	657:663	arg1	hyaluronan					665:674	lauroyl hyaluronan	657:674	lauroyl hyaluronan	657:674	The amphiphilic character of lauroyl hyaluronan enabled convenient loading of the films by both hydrophilic and hydrophobic drugs.
34547392	9	9	theme	strong	1207:1212	arg1	effect					1214:1219	The strong effect	1203:1219	The strong effect of albumin	1203:1230	The strong effect of albumin highlights the importance of considering biomolecules in the design of release experiments.
34547392	2	10	theme	drug	279:282	arg1	delivery					284:291	drug delivery	279:291	drug delivery	279:291	However, their potential in the field of drug delivery was not yet explored.
34547392	8	11	theme	octenidine	1099:1108	arg1	release					1076:1082	The release	1072:1082	The release of hydrophobic octenidine into pure buffer	1072:1125	The release of hydrophobic octenidine into pure buffer was almost negligible, but the addition of albumin did promote its release.
34547392	8	11	theme	octenidine	1099:1108	arg1	negligible					1138:1147	negligible	1138:1147	negligible	1138:1147	The release of hydrophobic octenidine into pure buffer was almost negligible, but the addition of albumin did promote its release.
34547392	5	12	theme	hyaluronan	665:674	arg1	character					644:652	The amphiphilic character	628:652	The amphiphilic character of lauroyl hyaluronan	628:674	The amphiphilic character of lauroyl hyaluronan enabled convenient loading of the films by both hydrophilic and hydrophobic drugs.
34547392	7	13	theme	sensitive	981:989	arg1	release					973:979	slower release	966:979	slower release sensitive to other parameters	966:1009	Hydrophilic diclofenac was released rapidly in all cases, while triclosan with medium hydrophobicity exhibited slower release sensitive to other parameters, reaching equilibrium values in the used experimental setup.
34547392	0	14	theme	small	101:105	arg1	molecules					107:115	small molecules	101:115	small molecules	101:115	Lauroyl hyaluronan films for local drug delivery: Preparation and factors influencing the release of small molecules.
34547392	7	15	with	triclosan	919:927	arg1	hydrophobicity					941:954	medium hydrophobicity	934:954	medium hydrophobicity	934:954	Hydrophilic diclofenac was released rapidly in all cases, while triclosan with medium hydrophobicity exhibited slower release sensitive to other parameters, reaching equilibrium values in the used experimental setup.
34547392	8	16	theme	hydrophobic	1087:1097	arg1	octenidine					1099:1108	hydrophobic octenidine	1087:1108	hydrophobic octenidine	1087:1108	The release of hydrophobic octenidine into pure buffer was almost negligible, but the addition of albumin did promote its release.
34547392	3	17	theme	hyaluronan	418:427	arg1	properties					429:438	lauroyl hyaluronan properties	410:438	lauroyl hyaluronan properties	410:438	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	3	17	theme	hyaluronan	418:427	arg1	hydrophobicity					446:459	drug hydrophobicity	441:459	drug hydrophobicity	441:459	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	3	17	theme	hyaluronan	418:427	arg1	composition					472:482	medium composition	465:482	medium composition	465:482	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	3	18	theme	lauroyl	332:338	arg1	films					351:355	lauroyl hyaluronan films	332:355	lauroyl hyaluronan films loaded with various drugs	332:381	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	6	19	theme	drug	806:809	arg1	hydrophobicity					811:824	drug hydrophobicity	806:824	drug hydrophobicity	806:824	Dominant factors influencing drug release were drug hydrophobicity and the presence of albumin.
34547392	1	20	theme	biodegradable	165:177	arg1	materials					179:187	safe and biodegradable materials	156:187	safe and biodegradable materials that seem promising for application in medicine	156:235	Lauroyl derivatives of hyaluronan are safe and biodegradable materials that seem promising for application in medicine.
34547392	1	20	theme	biodegradable	165:177	arg1	derivatives					126:136	Lauroyl derivatives	118:136	Lauroyl derivatives of hyaluronan	118:150	Lauroyl derivatives of hyaluronan are safe and biodegradable materials that seem promising for application in medicine.
34547392	0	21	theme	hyaluronan	8:17	arg1	films					19:23	Lauroyl hyaluronan films	0:23	Lauroyl hyaluronan films for local drug delivery: Preparation and factors influencing the release of small molecules.	0:116	Lauroyl hyaluronan films for local drug delivery: Preparation and factors influencing the release of small molecules.
34547392	8	22	theme	albumin	1170:1176	arg1	addition					1158:1165	the addition	1154:1165	the addition of albumin	1154:1176	The release of hydrophobic octenidine into pure buffer was almost negligible, but the addition of albumin did promote its release.
34547392	0	23	theme	Lauroyl	0:6	arg1	films					19:23	Lauroyl hyaluronan films	0:23	Lauroyl hyaluronan films for local drug delivery: Preparation and factors influencing the release of small molecules.	0:116	Lauroyl hyaluronan films for local drug delivery: Preparation and factors influencing the release of small molecules.
34547392	5	24	theme	amphiphilic	632:642	arg1	character					644:652	The amphiphilic character	628:652	The amphiphilic character of lauroyl hyaluronan	628:674	The amphiphilic character of lauroyl hyaluronan enabled convenient loading of the films by both hydrophilic and hydrophobic drugs.
34547392	3	25	theme	lauroyl	410:416	arg1	properties					429:438	lauroyl hyaluronan properties	410:438	lauroyl hyaluronan properties	410:438	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	3	25	theme	lauroyl	410:416	arg1	hydrophobicity					446:459	drug hydrophobicity	441:459	drug hydrophobicity	441:459	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	3	25	theme	lauroyl	410:416	arg1	composition					472:482	medium composition	465:482	medium composition	465:482	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	6	26	theme	drug	788:791	arg1	release					793:799	drug release	788:799	drug release	788:799	Dominant factors influencing drug release were drug hydrophobicity and the presence of albumin.
34547392	7	27	theme	Hydrophilic	855:865	arg1	diclofenac					867:876	Hydrophilic diclofenac	855:876	Hydrophilic diclofenac	855:876	Hydrophilic diclofenac was released rapidly in all cases, while triclosan with medium hydrophobicity exhibited slower release sensitive to other parameters, reaching equilibrium values in the used experimental setup.
34547392	7	28	theme	experimental	1052:1063	arg1	setup					1065:1069	the used experimental setup	1043:1069	the used experimental setup	1043:1069	Hydrophilic diclofenac was released rapidly in all cases, while triclosan with medium hydrophobicity exhibited slower release sensitive to other parameters, reaching equilibrium values in the used experimental setup.
34547392	4	29	from	present	539:545	arg1	applications					564:575	real clinical applications	550:575	real clinical applications	550:575	Since biomolecules will always be present in real clinical applications, media supplemented by albumin were also included.
34547392	4	30	theme	clinical	555:562	arg1	applications					564:575	real clinical applications	550:575	real clinical applications	550:575	Since biomolecules will always be present in real clinical applications, media supplemented by albumin were also included.
34547392	0	31	theme	molecules	107:115	arg1	release					90:96	the release	86:96	the release of small molecules	86:115	Lauroyl hyaluronan films for local drug delivery: Preparation and factors influencing the release of small molecules.
34547392	2	32	theme	delivery	284:291	arg1	field					270:274	the field	266:274	the field of drug delivery	266:291	However, their potential in the field of drug delivery was not yet explored.
34547392	0	33	theme	drug	35:38	arg1	delivery					40:47	local drug delivery	29:47	local drug delivery	29:47	Lauroyl hyaluronan films for local drug delivery: Preparation and factors influencing the release of small molecules.
34547392	4	34	theme	real	550:553	arg1	applications					564:575	real clinical applications	550:575	real clinical applications	550:575	Since biomolecules will always be present in real clinical applications, media supplemented by albumin were also included.
34547392	9	35	theme	considering	1261:1271	arg1	biomolecules					1273:1284	considering biomolecules	1261:1284	considering biomolecules	1261:1284	The strong effect of albumin highlights the importance of considering biomolecules in the design of release experiments.
34547392	8	36	theme	pure	1115:1118	arg1	buffer					1120:1125	pure buffer	1115:1125	pure buffer	1115:1125	The release of hydrophobic octenidine into pure buffer was almost negligible, but the addition of albumin did promote its release.
34547392	2	37	from	potential	253:261	arg1	field					270:274	the field	266:274	the field of drug delivery	266:291	However, their potential in the field of drug delivery was not yet explored.
34547392	0	38	theme	local	29:33	arg1	delivery					40:47	local drug delivery	29:47	local drug delivery	29:47	Lauroyl hyaluronan films for local drug delivery: Preparation and factors influencing the release of small molecules.
34547392	9	39	theme	biomolecules	1273:1284	arg1	importance					1247:1256	the importance	1243:1256	the importance of considering biomolecules in the design of release experiments	1243:1321	The strong effect of albumin highlights the importance of considering biomolecules in the design of release experiments.
34547392	7	40	theme	used	1047:1050	arg1	setup					1065:1069	the used experimental setup	1043:1069	the used experimental setup	1043:1069	Hydrophilic diclofenac was released rapidly in all cases, while triclosan with medium hydrophobicity exhibited slower release sensitive to other parameters, reaching equilibrium values in the used experimental setup.
34547392	3	41	theme	drug	441:444	arg1	properties					429:438	lauroyl hyaluronan properties	410:438	lauroyl hyaluronan properties	410:438	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	3	41	theme	drug	441:444	arg1	hydrophobicity					446:459	drug hydrophobicity	441:459	drug hydrophobicity	441:459	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	5	42	theme	hydrophilic	724:734	arg1	drugs					752:756	both hydrophilic and hydrophobic drugs	719:756	both hydrophilic and hydrophobic drugs	719:756	The amphiphilic character of lauroyl hyaluronan enabled convenient loading of the films by both hydrophilic and hydrophobic drugs.
34547392	1	43	from	application	213:223	arg1	medicine					228:235	medicine	228:235	medicine	228:235	Lauroyl derivatives of hyaluronan are safe and biodegradable materials that seem promising for application in medicine.
34547392	4	44	attach	present	539:545	arg2	biomolecules					511:522	biomolecules	511:522	biomolecules	511:522	Since biomolecules will always be present in real clinical applications, media supplemented by albumin were also included.
34547392	4	44	attach	present	539:545	arg1	applications					564:575	real clinical applications	550:575	real clinical applications	550:575	Since biomolecules will always be present in real clinical applications, media supplemented by albumin were also included.
34547392	9	45	theme	albumin	1224:1230	arg1	effect					1214:1219	The strong effect	1203:1219	The strong effect of albumin	1203:1230	The strong effect of albumin highlights the importance of considering biomolecules in the design of release experiments.
34547392	5	46	theme	convenient	684:693	arg1	loading					695:701	convenient loading	684:701	convenient loading of the films by both hydrophilic and hydrophobic drugs	684:756	The amphiphilic character of lauroyl hyaluronan enabled convenient loading of the films by both hydrophilic and hydrophobic drugs.
34547392	6	47	theme	Dominant	759:766	arg1	factors					768:774	Dominant factors	759:774	Dominant factors influencing drug release	759:799	Dominant factors influencing drug release were drug hydrophobicity and the presence of albumin.
34547392	9	48	from	importance	1247:1256	arg1	design					1293:1298	the design	1289:1298	the design of release experiments	1289:1321	The strong effect of albumin highlights the importance of considering biomolecules in the design of release experiments.
34547392	7	49	theme	slower	966:971	arg1	release					973:979	slower release	966:979	slower release sensitive to other parameters	966:1009	Hydrophilic diclofenac was released rapidly in all cases, while triclosan with medium hydrophobicity exhibited slower release sensitive to other parameters, reaching equilibrium values in the used experimental setup.
34547392	4	50	located	present	539:545	arg2	biomolecules					511:522	biomolecules	511:522	biomolecules	511:522	Since biomolecules will always be present in real clinical applications, media supplemented by albumin were also included.
34547392	4	50	located	present	539:545	arg1	applications					564:575	real clinical applications	550:575	real clinical applications	550:575	Since biomolecules will always be present in real clinical applications, media supplemented by albumin were also included.
34547392	1	51	theme	Lauroyl	118:124	arg1	materials					179:187	safe and biodegradable materials	156:187	safe and biodegradable materials that seem promising for application in medicine	156:235	Lauroyl derivatives of hyaluronan are safe and biodegradable materials that seem promising for application in medicine.
34547392	1	51	theme	Lauroyl	118:124	arg1	derivatives					126:136	Lauroyl derivatives	118:136	Lauroyl derivatives of hyaluronan	118:150	Lauroyl derivatives of hyaluronan are safe and biodegradable materials that seem promising for application in medicine.
34547392	7	52	theme	medium	934:939	arg1	hydrophobicity					941:954	medium hydrophobicity	934:954	medium hydrophobicity	934:954	Hydrophilic diclofenac was released rapidly in all cases, while triclosan with medium hydrophobicity exhibited slower release sensitive to other parameters, reaching equilibrium values in the used experimental setup.
34547392	5	53	theme	hydrophobic	740:750	arg1	drugs					752:756	both hydrophilic and hydrophobic drugs	719:756	both hydrophilic and hydrophobic drugs	719:756	The amphiphilic character of lauroyl hyaluronan enabled convenient loading of the films by both hydrophilic and hydrophobic drugs.
34547392	6	54	theme	albumin	846:852	arg1	hydrophobicity					811:824	drug hydrophobicity	806:824	drug hydrophobicity	806:824	Dominant factors influencing drug release were drug hydrophobicity and the presence of albumin.
34547392	6	54	theme	albumin	846:852	arg1	presence					834:841	the presence	830:841	the presence of albumin	830:852	Dominant factors influencing drug release were drug hydrophobicity and the presence of albumin.
34547392	0	55	dep	films	19:23	arg1	factors					66:72	factors	66:72	factors influencing the release of small molecules	66:115	Lauroyl hyaluronan films for local drug delivery: Preparation and factors influencing the release of small molecules.
34547392	0	55	dep	films	19:23	arg1	Preparation					50:60	Preparation	50:60	Preparation	50:60	Lauroyl hyaluronan films for local drug delivery: Preparation and factors influencing the release of small molecules.
34547392	7	56	theme	equilibrium	1021:1031	arg1	values					1033:1038	equilibrium values	1021:1038	equilibrium values	1021:1038	Hydrophilic diclofenac was released rapidly in all cases, while triclosan with medium hydrophobicity exhibited slower release sensitive to other parameters, reaching equilibrium values in the used experimental setup.
34547392	3	57	theme	medium	465:470	arg1	properties					429:438	lauroyl hyaluronan properties	410:438	lauroyl hyaluronan properties	410:438	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	3	57	theme	medium	465:470	arg1	composition					472:482	medium composition	465:482	medium composition	465:482	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	9	58	theme	release	1303:1309	arg1	experiments					1311:1321	release experiments	1303:1321	release experiments	1303:1321	The strong effect of albumin highlights the importance of considering biomolecules in the design of release experiments.
34547392	3	59	theme	properties	429:438	arg1	effects					399:405	the effects	395:405	the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release	395:502	We thus prepared lauroyl hyaluronan films loaded with various drugs and studied the effects of lauroyl hyaluronan properties, drug hydrophobicity and medium composition on the drug release.
34547392	9	60	theme	experiments	1311:1321	arg1	design					1293:1298	the design	1289:1298	the design of release experiments	1289:1321	The strong effect of albumin highlights the importance of considering biomolecules in the design of release experiments.
34547392	1	61	theme	hyaluronan	141:150	arg1	materials					179:187	safe and biodegradable materials	156:187	safe and biodegradable materials that seem promising for application in medicine	156:235	Lauroyl derivatives of hyaluronan are safe and biodegradable materials that seem promising for application in medicine.
34547392	1	61	theme	hyaluronan	141:150	arg1	derivatives					126:136	Lauroyl derivatives	118:136	Lauroyl derivatives of hyaluronan	118:150	Lauroyl derivatives of hyaluronan are safe and biodegradable materials that seem promising for application in medicine.
32649227	7	0	theme	Prepared	956:963	arg1	patches					965:971	Prepared patches	956:971	Prepared patches	956:971	Prepared patches were clear, smooth; uniform in appearance; with sharp pointed microprojections and remained intact after 1000 folding.
32649227	12	1	theme	partial	1599:1605	arg1	time					1622:1625	activated partial thromboplastin time	1589:1625	activated partial thromboplastin time (4 folds as compared to negative control)	1589:1667	A significant prolongation of activated partial thromboplastin time (4 folds as compared to negative control) was recorded following the application of heparin sodium loaded microneedle patch onto rabbit skin.
32649227	6	2	theme	thromboplastin	873:886	arg1	time					888:891	activated partial thromboplastin time	855:891	activated partial thromboplastin time	855:891	In-vivo activity of patches was confirmed by measuring activated partial thromboplastin time and histological examination of the micropierced skin tissues.
32649227	11	3	theme	drug	1538:1541	arg1	release					1516:1522	∼92% release	1511:1522	∼92% release of the loaded drug	1511:1541	In-vitro release study confirmed ∼92% release of the loaded drug within 120 min.
32649227	6	4	theme	activated	855:863	arg1	time					888:891	activated partial thromboplastin time	855:891	activated partial thromboplastin time	855:891	In-vivo activity of patches was confirmed by measuring activated partial thromboplastin time and histological examination of the micropierced skin tissues.
32649227	12	5	theme	significant	1561:1571	arg1	prolongation					1573:1584	A significant prolongation	1559:1584	A significant prolongation of activated partial thromboplastin time (4 folds as compared to negative control)	1559:1667	A significant prolongation of activated partial thromboplastin time (4 folds as compared to negative control) was recorded following the application of heparin sodium loaded microneedle patch onto rabbit skin.
32649227	11	6	theme	In-vitro	1478:1485	arg1	study					1495:1499	In-vitro release study	1478:1499	In-vitro release study	1478:1499	In-vitro release study confirmed ∼92% release of the loaded drug within 120 min.
32649227	1	7	theme	polyvinyl	200:208	arg1	alcohol					210:216	polyvinyl alcohol polymer and sorbitol	200:237	alcohol	210:216	The aim of this study was to develop heparin sodium loaded microneedle patches using different compositions of polyvinyl alcohol polymer and sorbitol.
32649227	10	8	from	examination	1381:1391	arg1	evident					1355:1361	evident	1355:1361	evident	1355:1361	Disrupted stratum corneum evident from histological examination confirmed successful insertion of the microneedle without affecting the vasculature.
32649227	13	9	theme	heparin	1925:1931	arg1	sodium					1933:1938	heparin sodium	1925:1938	heparin sodium	1925:1938	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	2	10	theme	heparin	320:326	arg1	sodium					328:333	heparin sodium	320:333	heparin sodium	320:333	A vacuum micromolding technique was used to fabricate microneedle patches while heparin sodium was loaded into needle tips.
32649227	12	11	theme	rabbit	1756:1761	arg1	skin					1763:1766	rabbit skin	1756:1766	rabbit skin	1756:1766	A significant prolongation of activated partial thromboplastin time (4 folds as compared to negative control) was recorded following the application of heparin sodium loaded microneedle patch onto rabbit skin.
32649227	11	12	theme	∼92	1511:1513	arg1	%					1514:1514	%	1514:1514	%	1514:1514	In-vitro release study confirmed ∼92% release of the loaded drug within 120 min.
32649227	5	13	theme	drug	778:781	arg1	profile					791:797	the in-vitro drug release profile	765:797	the in-vitro drug release profile	765:797	A preliminary assessment of the microneedle performance was studied by examining the in-vitro insertion to the parafilm and recording the in-vitro drug release profile.
32649227	2	14	theme	vacuum	242:247	arg1	technique					262:270	A vacuum micromolding technique	240:270	A vacuum micromolding technique	240:270	A vacuum micromolding technique was used to fabricate microneedle patches while heparin sodium was loaded into needle tips.
32649227	1	15	theme	sorbitol	230:237	arg1	compositions					184:195	different compositions	174:195	different compositions of polyvinyl alcohol polymer and sorbitol	174:237	The aim of this study was to develop heparin sodium loaded microneedle patches using different compositions of polyvinyl alcohol polymer and sorbitol.
32649227	12	16	theme	heparin	1711:1717	arg1	sodium					1719:1724	heparin sodium	1711:1724	heparin sodium	1711:1724	A significant prolongation of activated partial thromboplastin time (4 folds as compared to negative control) was recorded following the application of heparin sodium loaded microneedle patch onto rabbit skin.
32649227	7	17	with	clear	978:982	arg1	microprojections					1035:1050	sharp pointed microprojections	1021:1050	sharp pointed microprojections	1021:1050	Prepared patches were clear, smooth; uniform in appearance; with sharp pointed microprojections and remained intact after 1000 folding.
32649227	10	18	theme	stratum	1339:1345	arg1	corneum					1347:1353	Disrupted stratum corneum	1329:1353	Disrupted stratum corneum evident from histological examination	1329:1391	Disrupted stratum corneum evident from histological examination confirmed successful insertion of the microneedle without affecting the vasculature.
32649227	1	19	theme	sodium	134:139	arg1	patches					160:166	heparin sodium loaded microneedle patches	126:166	heparin sodium loaded microneedle patches	126:166	The aim of this study was to develop heparin sodium loaded microneedle patches using different compositions of polyvinyl alcohol polymer and sorbitol.
32649227	1	20	theme	microneedle	148:158	arg1	patches					160:166	heparin sodium loaded microneedle patches	126:166	heparin sodium loaded microneedle patches	126:166	The aim of this study was to develop heparin sodium loaded microneedle patches using different compositions of polyvinyl alcohol polymer and sorbitol.
32649227	8	21	from	microcavities	1151:1163	arg1	membrane					1181:1188	the parafilm membrane	1168:1188	the parafilm membrane	1168:1188	The microneedles were stiffer in nature, as they reproduce microcavities in the parafilm membrane following hand pushing without any structural loss.
32649227	10	22	theme	histological	1368:1379	arg1	examination					1381:1391	histological examination	1368:1391	histological examination	1368:1391	Disrupted stratum corneum evident from histological examination confirmed successful insertion of the microneedle without affecting the vasculature.
32649227	4	23	theme	scanning	540:547	arg1	microscopy					558:567	scanning electron microscopy	540:567	scanning electron microscopy	540:567	Patches were also characterised by optical microscopy and scanning electron microscopy to determine the microneedle length and surface morphologies.
32649227	10	24	theme	evident	1355:1361	arg1	corneum					1347:1353	Disrupted stratum corneum	1329:1353	Disrupted stratum corneum evident from histological examination	1329:1391	Disrupted stratum corneum evident from histological examination confirmed successful insertion of the microneedle without affecting the vasculature.
32649227	7	25	theme	sharp	1021:1025	arg1	microprojections					1035:1050	sharp pointed microprojections	1021:1050	sharp pointed microprojections	1021:1050	Prepared patches were clear, smooth; uniform in appearance; with sharp pointed microprojections and remained intact after 1000 folding.
32649227	13	26	theme	chronic	1992:1998	arg1	ailments					2000:2007	chronic ailments	1992:2007	chronic ailments	1992:2007	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	3	27	theme	Physical	364:371	arg1	features					373:380	Physical features	364:380	Physical features of patches	364:391	Physical features of patches were evaluated by measuring thickness, width, folding endurance and swelling percentage.
32649227	13	28	theme	delivery	1816:1823	arg1	microneedles					1783:1794	microneedles	1783:1794	microneedles	1783:1794	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	13	28	theme	delivery	1816:1823	arg1	system					1825:1830	a valuable drug delivery system	1800:1830	a valuable drug delivery system	1800:1830	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	3	29	theme	folding	439:445	arg1	endurance					447:455	folding endurance	439:455	folding endurance	439:455	Physical features of patches were evaluated by measuring thickness, width, folding endurance and swelling percentage.
32649227	4	30	theme	microneedle	586:596	arg1	length					598:603	the microneedle length	582:603	the microneedle length	582:603	Patches were also characterised by optical microscopy and scanning electron microscopy to determine the microneedle length and surface morphologies.
32649227	13	31	theme	valuable	1802:1809	arg1	microneedles					1783:1794	microneedles	1783:1794	microneedles	1783:1794	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	13	31	theme	valuable	1802:1809	arg1	system					1825:1830	a valuable drug delivery system	1800:1830	a valuable drug delivery system	1800:1830	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	13	32	theme	ailments	2000:2007	arg1	management					1978:1987	the management	1974:1987	the management of chronic ailments	1974:2007	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	0	33	theme	self-applicating	36:51	arg1	microneedle					68:78	self-applicating heparin sodium microneedle	36:78	self-applicating heparin sodium microneedle	36:78	Fabrication and characterisation of self-applicating heparin sodium microneedle patches.
32649227	6	34	theme	skin	942:945	arg1	tissues					947:953	the micropierced skin tissues	925:953	the micropierced skin tissues	925:953	In-vivo activity of patches was confirmed by measuring activated partial thromboplastin time and histological examination of the micropierced skin tissues.
32649227	13	35	theme	sustained	1945:1953	arg1	manner					1963:1968	a sustained release manner	1943:1968	a sustained release manner	1943:1968	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	6	36	theme	patches	820:826	arg1	activity					808:815	In-vivo activity	800:815	In-vivo activity of patches	800:826	In-vivo activity of patches was confirmed by measuring activated partial thromboplastin time and histological examination of the micropierced skin tissues.
32649227	0	37	theme	sodium	61:66	arg1	microneedle					68:78	self-applicating heparin sodium microneedle	36:78	self-applicating heparin sodium microneedle	36:78	Fabrication and characterisation of self-applicating heparin sodium microneedle patches.
32649227	12	38	theme	negative	1651:1658	arg1	control					1660:1666	negative control	1651:1666	negative control	1651:1666	A significant prolongation of activated partial thromboplastin time (4 folds as compared to negative control) was recorded following the application of heparin sodium loaded microneedle patch onto rabbit skin.
32649227	9	39	theme	microneedles	1297:1308	arg1	insertion					1284:1292	successful insertion	1273:1292	successful insertion of microneedles into the parafilm	1273:1326	Insertion study results showed successful insertion of microneedles into the parafilm.
32649227	2	40	theme	needle	351:356	arg1	tips					358:361	needle tips	351:361	needle tips	351:361	A vacuum micromolding technique was used to fabricate microneedle patches while heparin sodium was loaded into needle tips.
32649227	13	41	theme	release	1955:1961	arg1	manner					1963:1968	a sustained release manner	1943:1968	a sustained release manner	1943:1968	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	1	42	dep	alcohol	210:216	arg1	polymer					218:224	polymer	218:224	polymer	218:224	The aim of this study was to develop heparin sodium loaded microneedle patches using different compositions of polyvinyl alcohol polymer and sorbitol.
32649227	9	43	theme	Insertion	1242:1250	arg1	results					1258:1264	Insertion study results	1242:1264	Insertion study results	1242:1264	Insertion study results showed successful insertion of microneedles into the parafilm.
32649227	12	44	theme	activated	1589:1597	arg1	time					1622:1625	activated partial thromboplastin time	1589:1625	activated partial thromboplastin time (4 folds as compared to negative control)	1589:1667	A significant prolongation of activated partial thromboplastin time (4 folds as compared to negative control) was recorded following the application of heparin sodium loaded microneedle patch onto rabbit skin.
32649227	11	45	theme	%	1514:1514	arg1	release					1516:1522	∼92% release	1511:1522	∼92% release of the loaded drug	1511:1541	In-vitro release study confirmed ∼92% release of the loaded drug within 120 min.
32649227	8	46	theme	structural	1225:1234	arg1	loss					1236:1239	any structural loss	1221:1239	any structural loss	1221:1239	The microneedles were stiffer in nature, as they reproduce microcavities in the parafilm membrane following hand pushing without any structural loss.
32649227	12	47	theme	thromboplastin	1607:1620	arg1	time					1622:1625	activated partial thromboplastin time	1589:1625	activated partial thromboplastin time (4 folds as compared to negative control)	1589:1667	A significant prolongation of activated partial thromboplastin time (4 folds as compared to negative control) was recorded following the application of heparin sodium loaded microneedle patch onto rabbit skin.
32649227	13	48	theme	sodium	1933:1938	arg1	self-administration					1902:1920	self-administration	1902:1920	self-administration of heparin sodium in a sustained release manner	1902:1968	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	5	49	theme	in-vitro	716:723	arg1	insertion					725:733	the in-vitro insertion	712:733	the in-vitro insertion to the parafilm	712:749	A preliminary assessment of the microneedle performance was studied by examining the in-vitro insertion to the parafilm and recording the in-vitro drug release profile.
32649227	9	50	theme	successful	1273:1282	arg1	insertion					1284:1292	successful insertion	1273:1292	successful insertion of microneedles into the parafilm	1273:1326	Insertion study results showed successful insertion of microneedles into the parafilm.
32649227	11	51	theme	loaded	1531:1536	arg1	drug					1538:1541	the loaded drug	1527:1541	the loaded drug	1527:1541	In-vitro release study confirmed ∼92% release of the loaded drug within 120 min.
32649227	5	52	theme	performance	675:685	arg1	assessment					645:654	A preliminary assessment	631:654	A preliminary assessment of the microneedle performance	631:685	A preliminary assessment of the microneedle performance was studied by examining the in-vitro insertion to the parafilm and recording the in-vitro drug release profile.
32649227	6	53	theme	partial	865:871	arg1	time					888:891	activated partial thromboplastin time	855:891	activated partial thromboplastin time	855:891	In-vivo activity of patches was confirmed by measuring activated partial thromboplastin time and histological examination of the micropierced skin tissues.
32649227	2	54	theme	microneedle	294:304	arg1	patches					306:312	microneedle patches	294:312	microneedle patches	294:312	A vacuum micromolding technique was used to fabricate microneedle patches while heparin sodium was loaded into needle tips.
32649227	1	55	theme	different	174:182	arg1	compositions					184:195	different compositions	174:195	different compositions of polyvinyl alcohol polymer and sorbitol	174:237	The aim of this study was to develop heparin sodium loaded microneedle patches using different compositions of polyvinyl alcohol polymer and sorbitol.
32649227	2	56	used	used	276:279	arg2	technique					262:270	A vacuum micromolding technique	240:270	A vacuum micromolding technique	240:270	A vacuum micromolding technique was used to fabricate microneedle patches while heparin sodium was loaded into needle tips.
32649227	8	57	from	nature	1125:1130	arg1	stiffer					1114:1120	stiffer	1114:1120	stiffer	1114:1120	The microneedles were stiffer in nature, as they reproduce microcavities in the parafilm membrane following hand pushing without any structural loss.
32649227	8	57	from	nature	1125:1130	arg1	microneedles					1096:1107	The microneedles	1092:1107	The microneedles	1092:1107	The microneedles were stiffer in nature, as they reproduce microcavities in the parafilm membrane following hand pushing without any structural loss.
32649227	7	58	dep	clear	978:982	arg1	uniform					993:999	uniform	993:999	uniform	993:999	Prepared patches were clear, smooth; uniform in appearance; with sharp pointed microprojections and remained intact after 1000 folding.
32649227	1	59	theme	alcohol	210:216	arg1	compositions					184:195	different compositions	174:195	different compositions of polyvinyl alcohol polymer and sorbitol	174:237	The aim of this study was to develop heparin sodium loaded microneedle patches using different compositions of polyvinyl alcohol polymer and sorbitol.
32649227	8	60	from	stiffer	1114:1120	arg1	nature					1125:1130	nature	1125:1130	nature	1125:1130	The microneedles were stiffer in nature, as they reproduce microcavities in the parafilm membrane following hand pushing without any structural loss.
32649227	7	61	theme	pointed	1027:1033	arg1	microprojections					1035:1050	sharp pointed microprojections	1021:1050	sharp pointed microprojections	1021:1050	Prepared patches were clear, smooth; uniform in appearance; with sharp pointed microprojections and remained intact after 1000 folding.
32649227	13	62	theme	skin	1870:1873	arg1	invasion					1875:1882	minimal skin invasion	1862:1882	minimal skin invasion	1862:1882	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	5	63	theme	in-vitro	769:776	arg1	profile					791:797	the in-vitro drug release profile	765:797	the in-vitro drug release profile	765:797	A preliminary assessment of the microneedle performance was studied by examining the in-vitro insertion to the parafilm and recording the in-vitro drug release profile.
32649227	2	64	theme	micromolding	249:260	arg1	technique					262:270	A vacuum micromolding technique	240:270	A vacuum micromolding technique	240:270	A vacuum micromolding technique was used to fabricate microneedle patches while heparin sodium was loaded into needle tips.
32649227	12	65	theme	sodium	1719:1724	arg1	application					1696:1706	the application	1692:1706	the application of heparin sodium loaded microneedle patch onto rabbit skin	1692:1766	A significant prolongation of activated partial thromboplastin time (4 folds as compared to negative control) was recorded following the application of heparin sodium loaded microneedle patch onto rabbit skin.
32649227	11	66	theme	release	1487:1493	arg1	study					1495:1499	In-vitro release study	1478:1499	In-vitro release study	1478:1499	In-vitro release study confirmed ∼92% release of the loaded drug within 120 min.
32649227	13	67	dep	system	1825:1830	arg1	benefiting					1833:1842	benefiting	1833:1842	benefiting the patients with minimal skin invasion	1833:1882	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	13	67	dep	system	1825:1830	arg1	allowing					1893:1900	allowing	1893:1900	allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments	1893:2007	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	7	68	from	appearance	1004:1013	arg1	uniform					993:999	uniform	993:999	uniform	993:999	Prepared patches were clear, smooth; uniform in appearance; with sharp pointed microprojections and remained intact after 1000 folding.
32649227	1	69	theme	heparin	126:132	arg1	patches					160:166	heparin sodium loaded microneedle patches	126:166	heparin sodium loaded microneedle patches	126:166	The aim of this study was to develop heparin sodium loaded microneedle patches using different compositions of polyvinyl alcohol polymer and sorbitol.
32649227	10	70	theme	Disrupted	1329:1337	arg1	corneum					1347:1353	Disrupted stratum corneum	1329:1353	Disrupted stratum corneum evident from histological examination	1329:1391	Disrupted stratum corneum evident from histological examination confirmed successful insertion of the microneedle without affecting the vasculature.
32649227	12	71	dep	4	1628:1628	arg1	folds					1630:1634	folds	1630:1634	folds as compared to negative control	1630:1666	A significant prolongation of activated partial thromboplastin time (4 folds as compared to negative control) was recorded following the application of heparin sodium loaded microneedle patch onto rabbit skin.
32649227	1	72	theme	loaded	141:146	arg1	patches					160:166	heparin sodium loaded microneedle patches	126:166	heparin sodium loaded microneedle patches	126:166	The aim of this study was to develop heparin sodium loaded microneedle patches using different compositions of polyvinyl alcohol polymer and sorbitol.
32649227	12	73	dep	time	1622:1625	arg1	4					1628:1628	4	1628:1628	4	1628:1628	A significant prolongation of activated partial thromboplastin time (4 folds as compared to negative control) was recorded following the application of heparin sodium loaded microneedle patch onto rabbit skin.
32649227	4	74	theme	electron	549:556	arg1	microscopy					558:567	scanning electron microscopy	540:567	scanning electron microscopy	540:567	Patches were also characterised by optical microscopy and scanning electron microscopy to determine the microneedle length and surface morphologies.
32649227	13	75	with	patients	1848:1855	arg1	invasion					1875:1882	minimal skin invasion	1862:1882	minimal skin invasion	1862:1882	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	5	76	theme	release	783:789	arg1	profile					791:797	the in-vitro drug release profile	765:797	the in-vitro drug release profile	765:797	A preliminary assessment of the microneedle performance was studied by examining the in-vitro insertion to the parafilm and recording the in-vitro drug release profile.
32649227	3	77	theme	patches	385:391	arg1	features					373:380	Physical features	364:380	Physical features of patches	364:391	Physical features of patches were evaluated by measuring thickness, width, folding endurance and swelling percentage.
32649227	13	78	theme	minimal	1862:1868	arg1	invasion					1875:1882	minimal skin invasion	1862:1882	minimal skin invasion	1862:1882	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	5	79	theme	microneedle	663:673	arg1	performance					675:685	the microneedle performance	659:685	the microneedle performance	659:685	A preliminary assessment of the microneedle performance was studied by examining the in-vitro insertion to the parafilm and recording the in-vitro drug release profile.
32649227	4	80	theme	optical	517:523	arg1	microscopy					525:534	optical microscopy	517:534	optical microscopy	517:534	Patches were also characterised by optical microscopy and scanning electron microscopy to determine the microneedle length and surface morphologies.
32649227	10	81	theme	successful	1403:1412	arg1	insertion					1414:1422	successful insertion	1403:1422	successful insertion of the microneedle	1403:1441	Disrupted stratum corneum evident from histological examination confirmed successful insertion of the microneedle without affecting the vasculature.
32649227	3	82	theme	swelling	461:468	arg1	percentage					470:479	swelling percentage	461:479	swelling percentage	461:479	Physical features of patches were evaluated by measuring thickness, width, folding endurance and swelling percentage.
32649227	13	83	from	self-administration	1902:1920	arg1	manner					1963:1968	a sustained release manner	1943:1968	a sustained release manner	1943:1968	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	5	84	theme	preliminary	633:643	arg1	assessment					645:654	A preliminary assessment	631:654	A preliminary assessment of the microneedle performance	631:685	A preliminary assessment of the microneedle performance was studied by examining the in-vitro insertion to the parafilm and recording the in-vitro drug release profile.
32649227	1	85	theme	study	105:109	arg1	aim					93:95	The aim	89:95	The aim of this study	89:109	The aim of this study was to develop heparin sodium loaded microneedle patches using different compositions of polyvinyl alcohol polymer and sorbitol.
32649227	4	86	theme	surface	609:615	arg1	morphologies					617:628	surface morphologies	609:628	surface morphologies	609:628	Patches were also characterised by optical microscopy and scanning electron microscopy to determine the microneedle length and surface morphologies.
32649227	7	87	from	uniform	993:999	arg1	appearance					1004:1013	appearance	1004:1013	appearance	1004:1013	Prepared patches were clear, smooth; uniform in appearance; with sharp pointed microprojections and remained intact after 1000 folding.
32649227	10	88	theme	microneedle	1431:1441	arg1	insertion					1414:1422	successful insertion	1403:1422	successful insertion of the microneedle	1403:1441	Disrupted stratum corneum evident from histological examination confirmed successful insertion of the microneedle without affecting the vasculature.
32649227	0	89	theme	heparin	53:59	arg1	microneedle					68:78	self-applicating heparin sodium microneedle	36:78	self-applicating heparin sodium microneedle	36:78	Fabrication and characterisation of self-applicating heparin sodium microneedle patches.
32649227	13	90	from	system	1825:1830	arg1	conclusion					1772:1781	conclusion	1772:1781	conclusion	1772:1781	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	8	91	theme	parafilm	1172:1179	arg1	membrane					1181:1188	the parafilm membrane	1168:1188	the parafilm membrane	1168:1188	The microneedles were stiffer in nature, as they reproduce microcavities in the parafilm membrane following hand pushing without any structural loss.
32649227	6	92	theme	tissues	947:953	arg1	time					888:891	activated partial thromboplastin time	855:891	activated partial thromboplastin time	855:891	In-vivo activity of patches was confirmed by measuring activated partial thromboplastin time and histological examination of the micropierced skin tissues.
32649227	6	92	theme	tissues	947:953	arg1	examination					910:920	histological examination	897:920	histological examination	897:920	In-vivo activity of patches was confirmed by measuring activated partial thromboplastin time and histological examination of the micropierced skin tissues.
32649227	13	93	theme	drug	1811:1814	arg1	microneedles					1783:1794	microneedles	1783:1794	microneedles	1783:1794	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	13	93	theme	drug	1811:1814	arg1	system					1825:1830	a valuable drug delivery system	1800:1830	a valuable drug delivery system	1800:1830	In conclusion microneedles are a valuable drug delivery system, benefiting the patients with minimal skin invasion and also allowing self-administration of heparin sodium in a sustained release manner for the management of chronic ailments.
32649227	0	94	theme	microneedle	68:78	arg1	characterisation					16:31	characterisation	16:31	characterisation	16:31	Fabrication and characterisation of self-applicating heparin sodium microneedle patches.
32649227	0	94	theme	microneedle	68:78	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and characterisation of self-applicating heparin sodium microneedle patches.
32649227	6	95	theme	micropierced	929:940	arg1	tissues					947:953	the micropierced skin tissues	925:953	the micropierced skin tissues	925:953	In-vivo activity of patches was confirmed by measuring activated partial thromboplastin time and histological examination of the micropierced skin tissues.
32649227	12	96	theme	time	1622:1625	arg1	prolongation					1573:1584	A significant prolongation	1559:1584	A significant prolongation of activated partial thromboplastin time (4 folds as compared to negative control)	1559:1667	A significant prolongation of activated partial thromboplastin time (4 folds as compared to negative control) was recorded following the application of heparin sodium loaded microneedle patch onto rabbit skin.
32649227	6	97	theme	In-vivo	800:806	arg1	activity					808:815	In-vivo activity	800:815	In-vivo activity of patches	800:826	In-vivo activity of patches was confirmed by measuring activated partial thromboplastin time and histological examination of the micropierced skin tissues.
32649227	6	98	theme	histological	897:908	arg1	examination					910:920	histological examination	897:920	histological examination	897:920	In-vivo activity of patches was confirmed by measuring activated partial thromboplastin time and histological examination of the micropierced skin tissues.
32649227	9	99	theme	study	1252:1256	arg1	results					1258:1264	Insertion study results	1242:1264	Insertion study results	1242:1264	Insertion study results showed successful insertion of microneedles into the parafilm.
33908161	1	0	theme	hyaluronic	205:214	arg1	acid					216:219	hyaluronic acid	205:219	hyaluronic acid	205:219	BACKGROUND In the skin, hyaluronic acid is broken down to smaller fragments by hyaluronidase enzymes, particularly when skin is wounded.
33908161	4	1	dep	concentrations	1103:1116	arg1	%					1101:1101	%	1101:1101	%	1101:1101	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	7	2	theme	commercial	1536:1545	arg1	complex					1547:1553	the commercial complex	1532:1553	the commercial complex	1532:1553	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	8	3	theme	molecular	1859:1867	arg1	weight					1869:1874	molecular weight	1859:1874	molecular weight	1859:1874	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	3	4	dep	Mw	596:597	arg1	1					585:585	1	585:585	1	585:585	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	0	5	theme	molecular	153:161	arg1	weight					163:168	HA molecular weight	150:168	HA molecular weight	150:168	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	8	6	dep	CONCLUSIONS	1679:1689	arg1	demonstrated					1712:1723	demonstrated	1712:1723	was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.	1708:1885	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	3	7	theme	critical	864:871	arg1	targets					891:897	two critical skin cell protein targets	860:897	two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	860:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	7	theme	critical	864:871	arg1	synthase-1					911:920	hyaluronan synthase-1	900:920	hyaluronan synthase-1 (HAS-1)	900:928	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	7	theme	critical	864:871	arg1	cluster					957:963	the HA binding protein cluster	934:963	the HA binding protein cluster of differentiation 44 (CD44)	934:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	4	8	theme	solution	1130:1137	arg1	solution					1130:1137	the 1.0% solution	1121:1137	the 1.0% solution	1121:1137	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	4	8	theme	solution	1130:1137	arg1	concentrations					1103:1116	1.0, 0.5, and 0.1% concentrations	1084:1116	1.0, 0.5, and 0.1% concentrations of the 1.0% solution	1084:1137	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	4	8	theme	solution	1130:1137	arg1	composite					1162:1170	the polysaccharide composite	1143:1170	the polysaccharide composite at the same concentrations for 48 Hrs	1143:1208	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	0	9	theme	proteins	86:93	arg1	expression					45:54	the in vitro expression	32:54	the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs)	32:141	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	7	10	theme	expression	1482:1491	arg1	Examination					1450:1460	Examination	1450:1460	Examination of the CD44 protein expression	1450:1491	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	3	11	theme	fraction	660:667	arg1	AIMS					507:510	AIMS	507:510	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).	507:993	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	11	theme	fraction	660:667	arg1	Examination					512:522	Examination	512:522	Examination of three molecular weight (Mw) fractions of hyaluronic acid	512:582	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	11	theme	fraction	660:667	arg1	Mw					698:699	3) average Mw	687:699	3) average Mw of the low fraction	687:719	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	11	theme	fraction	660:667	arg1	Mw					643:644	1.5-2 MDa, 2) average Mw	621:644	Mw	643:644	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	11	theme	fraction	660:667	arg1	200-500 kDa					670:680	200-500 kDa	670:680	200-500 kDa	670:680	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	11	theme	fraction	660:667	arg1	Mw					596:597	1) average Mw	585:597	1) average Mw of the high fraction	585:618	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	0	12	theme	normal	98:103	arg1	keratinocytes					121:133	normal human epidermal keratinocytes	98:133	normal human epidermal keratinocytes (NHEKs)	98:141	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	0	12	theme	normal	98:103	arg1	NHEKs					136:140	NHEKs	136:140	NHEKs	136:140	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	3	13	theme	weight	543:548	arg1	fractions					555:563	three molecular weight (Mw) fractions	527:563	three molecular weight (Mw) fractions of hyaluronic acid	527:582	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	6	14	theme	expression	1337:1346	arg1	Examination					1308:1318	Examination	1308:1318	Examination of HAS-1 protein expression	1308:1346	RESULTS Examination of HAS-1 protein expression indicates that none of the HA test materials influenced the expression of HAS-1 at any concentration.
33908161	6	15	theme	HAS-1	1422:1426	arg1	expression					1408:1417	the expression	1404:1417	the expression of HAS-1 at any concentration	1404:1447	RESULTS Examination of HAS-1 protein expression indicates that none of the HA test materials influenced the expression of HAS-1 at any concentration.
33908161	4	16	theme	1.0	1125:1127	arg1	%					1128:1128	%	1128:1128	%	1128:1128	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	0	17	theme	epidermal	111:119	arg1	keratinocytes					121:133	normal human epidermal keratinocytes	98:133	normal human epidermal keratinocytes (NHEKs)	98:141	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	0	17	theme	epidermal	111:119	arg1	NHEKs					136:140	NHEKs	136:140	NHEKs	136:140	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	6	18	theme	HAS-1	1323:1327	arg1	expression					1337:1346	HAS-1 protein expression	1323:1346	HAS-1 protein expression	1323:1346	RESULTS Examination of HAS-1 protein expression indicates that none of the HA test materials influenced the expression of HAS-1 at any concentration.
33908161	3	19	theme	fraction	712:719	arg1	AIMS					507:510	AIMS	507:510	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).	507:993	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	19	theme	fraction	712:719	arg1	Examination					512:522	Examination	512:522	Examination of three molecular weight (Mw) fractions of hyaluronic acid	512:582	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	19	theme	fraction	712:719	arg1	Mw					698:699	3) average Mw	687:699	3) average Mw of the low fraction	687:719	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	19	theme	fraction	712:719	arg1	Mw					643:644	1.5-2 MDa, 2) average Mw	621:644	Mw	643:644	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	19	theme	fraction	712:719	arg1	200-500 kDa					670:680	200-500 kDa	670:680	200-500 kDa	670:680	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	19	theme	fraction	712:719	arg1	Mw					596:597	1) average Mw	585:597	1) average Mw of the high fraction	585:618	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	20	from	targets	891:897	arg1	influence					837:845	the influence	833:845	the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	833:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	21	dep	Mw	698:699	arg1	3					687:687	3	687:687	3	687:687	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	22	theme	fractions	555:563	arg1	AIMS					507:510	AIMS	507:510	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).	507:993	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	22	theme	fractions	555:563	arg1	Examination					512:522	Examination	512:522	Examination of three molecular weight (Mw) fractions of hyaluronic acid	512:582	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	22	theme	fractions	555:563	arg1	Mw					698:699	3) average Mw	687:699	3) average Mw of the low fraction	687:719	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	22	theme	fractions	555:563	arg1	Mw					643:644	1.5-2 MDa, 2) average Mw	621:644	Mw	643:644	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	22	theme	fractions	555:563	arg1	200-500 kDa					670:680	200-500 kDa	670:680	200-500 kDa	670:680	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	22	theme	fractions	555:563	arg1	Mw					596:597	1) average Mw	585:597	1) average Mw of the high fraction	585:618	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	7	23	theme	CD44	1469:1472	arg1	expression					1482:1491	the CD44 protein expression	1465:1491	the CD44 protein expression	1465:1491	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	7	24	from	expression	1606:1615	arg1	NHEKs					1620:1624	NHEKs	1620:1624	NHEKs	1620:1624	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	6	25	from	concentration	1435:1447	arg1	expression					1408:1417	the expression	1404:1417	the expression of HAS-1 at any concentration	1404:1447	RESULTS Examination of HAS-1 protein expression indicates that none of the HA test materials influenced the expression of HAS-1 at any concentration.
33908161	6	26	theme	materials	1383:1391	arg1	none					1363:1366	none	1363:1366	none of the HA test materials	1363:1391	RESULTS Examination of HAS-1 protein expression indicates that none of the HA test materials influenced the expression of HAS-1 at any concentration.
33908161	3	27	theme	acid	579:582	arg1	fractions					555:563	three molecular weight (Mw) fractions	527:563	three molecular weight (Mw) fractions of hyaluronic acid	527:582	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	2	28	theme	proteins	468:475	arg1	expression					435:444	expression	435:444	expression of important cellular proteins	435:475	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	0	29	theme	proteins	64:71	arg1	expression					45:54	the in vitro expression	32:54	the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs)	32:141	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	3	30	theme	cell	878:881	arg1	targets					891:897	two critical skin cell protein targets	860:897	two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	860:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	30	theme	cell	878:881	arg1	synthase-1					911:920	hyaluronan synthase-1	900:920	hyaluronan synthase-1 (HAS-1)	900:928	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	30	theme	cell	878:881	arg1	cluster					957:963	the HA binding protein cluster	934:963	the HA binding protein cluster of differentiation 44 (CD44)	934:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	6	31	theme	HA	1375:1376	arg1	materials					1383:1391	the HA test materials	1371:1391	the HA test materials	1371:1391	RESULTS Examination of HAS-1 protein expression indicates that none of the HA test materials influenced the expression of HAS-1 at any concentration.
33908161	2	32	theme	important	449:457	arg1	proteins					468:475	important cellular proteins	449:475	important cellular proteins	449:475	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	2	33	theme	molecular	340:348	arg1	fragments					357:365	various molecular weight fragments	332:365	various molecular weight fragments of HA	332:371	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	7	34	theme	Mw	1654:1655	arg1	fractions					1660:1668	high Mw HA fractions	1649:1668	high Mw HA fractions	1649:1668	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	3	35	theme	1:1:1	744:748	arg1	complex					760:766	a unique 1:1:1 composite complex	735:766	a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid)	735:811	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	8	36	theme	CD44	1765:1768	arg1	protein					1770:1776	CD44 protein	1765:1776	CD44 protein	1765:1776	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	8	36	theme	CD44	1765:1768	arg1	protein					1818:1824	a critical HA transmembrane HA binding protein	1779:1824	a critical HA transmembrane HA binding protein	1779:1824	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	2	37	theme	epidermal	389:397	arg1	NHEK					414:417	NHEK	414:417	NHEK	414:417	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	2	37	theme	epidermal	389:397	arg1	keratinocytes					399:411	normal human epidermal keratinocytes	376:411	normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins	376:475	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	0	38	theme	Hyaluronic	0:9	arg1	HA					17:18	HA	17:18	HA	17:18	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	0	38	theme	Hyaluronic	0:9	arg1	acid					11:14	Hyaluronic acid	0:14	Hyaluronic acid (HA)	0:19	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	3	39	theme	hyaluronan	900:909	arg1	HAS-1					923:927	HAS-1	923:927	HAS-1	923:927	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	39	theme	hyaluronan	900:909	arg1	targets					891:897	two critical skin cell protein targets	860:897	two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	860:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	39	theme	hyaluronan	900:909	arg1	synthase-1					911:920	hyaluronan synthase-1	900:920	hyaluronan synthase-1 (HAS-1)	900:928	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	40	theme	HA	781:782	arg1	Acid					807:810	Triluronic® Acid	795:810	Triluronic® Acid	795:810	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	40	theme	HA	781:782	arg1	fragments					784:792	the three HA fragments	771:792	the three HA fragments (Triluronic® Acid)	771:811	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	2	41	theme	normal	376:381	arg1	NHEK					414:417	NHEK	414:417	NHEK	414:417	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	2	41	theme	normal	376:381	arg1	keratinocytes					399:411	normal human epidermal keratinocytes	376:411	normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins	376:475	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	2	42	theme	HA	370:371	arg1	fragments					357:365	various molecular weight fragments	332:365	various molecular weight fragments of HA	332:371	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	3	43	dep	targets	891:897	arg1	HAS-1					923:927	HAS-1	923:927	HAS-1	923:927	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	43	dep	targets	891:897	arg1	targets					891:897	two critical skin cell protein targets	860:897	two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	860:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	43	dep	targets	891:897	arg1	synthase-1					911:920	hyaluronan synthase-1	900:920	hyaluronan synthase-1 (HAS-1)	900:928	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	43	dep	targets	891:897	arg1	CD44					988:991	CD44	988:991	CD44	988:991	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	43	dep	targets	891:897	arg1	cluster					957:963	the HA binding protein cluster	934:963	the HA binding protein cluster of differentiation 44 (CD44)	934:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	7	44	theme	medium	1635:1640	arg1	Mw					1642:1643	the medium Mw	1631:1643	the medium Mw	1631:1643	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	8	45	theme	critical	1781:1788	arg1	protein					1818:1824	a critical HA transmembrane HA binding protein	1779:1824	a critical HA transmembrane HA binding protein	1779:1824	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	8	45	theme	critical	1781:1788	arg1	protein					1770:1776	CD44 protein	1765:1776	CD44 protein	1765:1776	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	5	46	theme	CD44	1278:1281	arg1	content					1291:1297	CD44 protein content	1278:1297	CD44 protein content	1278:1297	The cells were than analyzed by ELISA protein assays for HAS-1 and CD44 protein content.
33908161	6	47	dep	RESULTS	1300:1306	arg1	indicates					1348:1356	indicates	1348:1356	indicates that none of the HA test materials influenced the expression of HAS-1 at any concentration	1348:1447	RESULTS Examination of HAS-1 protein expression indicates that none of the HA test materials influenced the expression of HAS-1 at any concentration.
33908161	2	48	theme	fragments	357:365	arg1	impact					322:327	The impact	318:327	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins	318:475	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	8	49	theme	transmembrane	1793:1805	arg1	protein					1818:1824	a critical HA transmembrane HA binding protein	1779:1824	a critical HA transmembrane HA binding protein	1779:1824	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	8	49	theme	transmembrane	1793:1805	arg1	protein					1770:1776	CD44 protein	1765:1776	CD44 protein	1765:1776	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	5	50	theme	ELISA	1243:1247	arg1	assays					1257:1262	ELISA protein assays	1243:1262	ELISA protein assays for HAS-1 and CD44 protein content	1243:1297	The cells were than analyzed by ELISA protein assays for HAS-1 and CD44 protein content.
33908161	4	51	theme	Mw	1069:1070	arg1	fraction					1072:1079	each HA Mw fraction	1061:1079	each HA Mw fraction	1061:1079	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	1	52	theme	hyaluronidase	260:272	arg1	enzymes					274:280	hyaluronidase enzymes	260:280	hyaluronidase enzymes	260:280	BACKGROUND In the skin, hyaluronic acid is broken down to smaller fragments by hyaluronidase enzymes, particularly when skin is wounded.
33908161	7	53	theme	Mw	1568:1569	arg1	fractions					1571:1579	the three Mw fractions	1558:1579	the three Mw fractions	1558:1579	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	8	54	theme	binding	1810:1816	arg1	protein					1818:1824	a critical HA transmembrane HA binding protein	1779:1824	a critical HA transmembrane HA binding protein	1779:1824	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	8	54	theme	binding	1810:1816	arg1	protein					1770:1776	CD44 protein	1765:1776	CD44 protein	1765:1776	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	4	55	theme	%	1041:1041	arg1	solution					1049:1056	a 1.0% stock solution	1036:1056	a 1.0% stock solution of each HA Mw fraction	1036:1079	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	3	56	theme	binding	941:947	arg1	targets					891:897	two critical skin cell protein targets	860:897	two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	860:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	56	theme	binding	941:947	arg1	CD44					988:991	CD44	988:991	CD44	988:991	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	56	theme	binding	941:947	arg1	cluster					957:963	the HA binding protein cluster	934:963	the HA binding protein cluster of differentiation 44 (CD44)	934:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	57	from	influence	837:845	arg1	targets					891:897	two critical skin cell protein targets	860:897	two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	860:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	57	from	influence	837:845	arg1	synthase-1					911:920	hyaluronan synthase-1	900:920	hyaluronan synthase-1 (HAS-1)	900:928	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	57	from	influence	837:845	arg1	cluster					957:963	the HA binding protein cluster	934:963	the HA binding protein cluster of differentiation 44 (CD44)	934:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	4	58	from	concentrations	1184:1197	arg1	solution					1130:1137	the 1.0% solution	1121:1137	the 1.0% solution	1121:1137	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	4	58	from	concentrations	1184:1197	arg1	concentrations					1103:1116	1.0, 0.5, and 0.1% concentrations	1084:1116	1.0, 0.5, and 0.1% concentrations of the 1.0% solution	1084:1137	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	4	58	from	concentrations	1184:1197	arg1	composite					1162:1170	the polysaccharide composite	1143:1170	the polysaccharide composite at the same concentrations for 48 Hrs	1143:1208	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	3	59	theme	fraction	611:618	arg1	AIMS					507:510	AIMS	507:510	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).	507:993	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	59	theme	fraction	611:618	arg1	Examination					512:522	Examination	512:522	Examination of three molecular weight (Mw) fractions of hyaluronic acid	512:582	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	59	theme	fraction	611:618	arg1	Mw					698:699	3) average Mw	687:699	3) average Mw of the low fraction	687:719	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	59	theme	fraction	611:618	arg1	Mw					643:644	1.5-2 MDa, 2) average Mw	621:644	Mw	643:644	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	59	theme	fraction	611:618	arg1	200-500 kDa					670:680	200-500 kDa	670:680	200-500 kDa	670:680	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	59	theme	fraction	611:618	arg1	Mw					596:597	1) average Mw	585:597	1) average Mw of the high fraction	585:618	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	60	theme	differentiation	968:982	arg1	HAS-1					923:927	HAS-1	923:927	HAS-1	923:927	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	60	theme	differentiation	968:982	arg1	targets					891:897	two critical skin cell protein targets	860:897	two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	860:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	60	theme	differentiation	968:982	arg1	synthase-1					911:920	hyaluronan synthase-1	900:920	hyaluronan synthase-1 (HAS-1)	900:928	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	60	theme	differentiation	968:982	arg1	CD44					988:991	CD44	988:991	CD44	988:991	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	60	theme	differentiation	968:982	arg1	cluster					957:963	the HA binding protein cluster	934:963	the HA binding protein cluster of differentiation 44 (CD44)	934:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	61	theme	hyaluronic	568:577	arg1	acid					579:582	hyaluronic acid	568:582	hyaluronic acid	568:582	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	7	62	theme	protein	1598:1604	arg1	expression					1606:1615	CD44 protein expression	1593:1615	CD44 protein expression in NHEKs	1593:1624	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	7	63	theme	Mw	1516:1517	arg1	fraction					1519:1526	the low Mw fraction	1508:1526	the low Mw fraction	1508:1526	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	0	64	theme	HA	150:151	arg1	weight					163:168	HA molecular weight	150:168	HA molecular weight	150:168	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	7	65	theme	CD44	1593:1596	arg1	expression					1606:1615	CD44 protein expression	1593:1615	CD44 protein expression in NHEKs	1593:1624	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	7	66	theme	low	1512:1514	arg1	fraction					1519:1526	the low Mw fraction	1508:1526	the low Mw fraction	1508:1526	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	3	67	theme	HA	854:855	arg1	influence					837:845	the influence	833:845	the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	833:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	68	theme	average	588:594	arg1	AIMS					507:510	AIMS	507:510	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).	507:993	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	68	theme	average	588:594	arg1	Mw					596:597	1) average Mw	585:597	1) average Mw of the high fraction	585:618	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	4	69	theme	%	1128:1128	arg1	solution					1130:1137	the 1.0% solution	1121:1137	the 1.0% solution	1121:1137	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	3	70	theme	average	635:641	arg1	Mw					643:644	1.5-2 MDa, 2) average Mw	621:644	Mw	643:644	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	70	theme	average	635:641	arg1	AIMS					507:510	AIMS	507:510	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).	507:993	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	0	71	theme	human	105:109	arg1	keratinocytes					121:133	normal human epidermal keratinocytes	98:133	normal human epidermal keratinocytes (NHEKs)	98:141	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	0	71	theme	human	105:109	arg1	NHEKs					136:140	NHEKs	136:140	NHEKs	136:140	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	3	72	theme	molecular	533:541	arg1	Mw					551:552	Mw	551:552	Mw	551:552	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	72	theme	molecular	533:541	arg1	weight					543:548	three molecular weight	527:548	three molecular weight (Mw) fractions of hyaluronic acid	527:582	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	4	73	dep	%	1101:1101	arg1	0.5					1089:1091	0.5	1089:1091	0.5	1089:1091	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	4	73	dep	%	1101:1101	arg1	0.1					1098:1100	0.1	1098:1100	0.1	1098:1100	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	1	74	dep	BACKGROUND	181:190	arg1	broken					224:229	broken	224:229	broken	224:229	BACKGROUND In the skin, hyaluronic acid is broken down to smaller fragments by hyaluronidase enzymes, particularly when skin is wounded.
33908161	6	75	theme	protein	1329:1335	arg1	expression					1337:1346	HAS-1 protein expression	1323:1346	HAS-1 protein expression	1323:1346	RESULTS Examination of HAS-1 protein expression indicates that none of the HA test materials influenced the expression of HAS-1 at any concentration.
33908161	4	76	theme	METHODS	995:1001	arg1	NHEKs					1003:1007	METHODS NHEKs	995:1007	METHODS NHEKs	995:1007	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	7	77	theme	HA	1657:1658	arg1	fractions					1660:1668	high Mw HA fractions	1649:1668	high Mw HA fractions	1649:1668	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	3	78	theme	medium	653:658	arg1	fraction					660:667	the medium fraction	649:667	the medium fraction	649:667	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	7	79	theme	fractions	1571:1579	arg1	complex					1547:1553	the commercial complex	1532:1553	the commercial complex	1532:1553	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	7	79	theme	fractions	1571:1579	arg1	fraction					1519:1526	the low Mw fraction	1508:1526	the low Mw fraction	1508:1526	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	4	80	theme	same	1179:1182	arg1	concentrations					1184:1197	the same concentrations	1175:1197	the same concentrations for 48 Hrs	1175:1208	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	3	81	theme	low	708:710	arg1	fraction					712:719	the low fraction	704:719	the low fraction	704:719	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	0	82	theme	CD44	59:62	arg1	proteins					64:71	CD44 proteins	59:71	CD44 proteins but not HAS1 proteins	59:93	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	3	83	theme	protein	883:889	arg1	targets					891:897	two critical skin cell protein targets	860:897	two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	860:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	83	theme	protein	883:889	arg1	synthase-1					911:920	hyaluronan synthase-1	900:920	hyaluronan synthase-1 (HAS-1)	900:928	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	83	theme	protein	883:889	arg1	cluster					957:963	the HA binding protein cluster	934:963	the HA binding protein cluster of differentiation 44 (CD44)	934:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	84	dep	AIMS	507:510	arg1	done					817:820	done	817:820	was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	813:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	84	dep	AIMS	507:510	arg1	AIMS					507:510	AIMS	507:510	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).	507:993	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	84	dep	AIMS	507:510	arg1	Examination					512:522	Examination	512:522	Examination of three molecular weight (Mw) fractions of hyaluronic acid	512:582	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	84	dep	AIMS	507:510	arg1	Mw					698:699	3) average Mw	687:699	3) average Mw of the low fraction	687:719	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	84	dep	AIMS	507:510	arg1	Mw					643:644	1.5-2 MDa, 2) average Mw	621:644	Mw	643:644	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	84	dep	AIMS	507:510	arg1	200-500 kDa					670:680	200-500 kDa	670:680	200-500 kDa	670:680	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	84	dep	AIMS	507:510	arg1	Mw					596:597	1) average Mw	585:597	1) average Mw of the high fraction	585:618	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	85	theme	unique	737:742	arg1	complex					760:766	a unique 1:1:1 composite complex	735:766	a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid)	735:811	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	4	86	theme	polysaccharide	1147:1160	arg1	solution					1130:1137	the 1.0% solution	1121:1137	the 1.0% solution	1121:1137	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	4	86	theme	polysaccharide	1147:1160	arg1	composite					1162:1170	the polysaccharide composite	1143:1170	the polysaccharide composite at the same concentrations for 48 Hrs	1143:1208	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	3	87	theme	skin	873:876	arg1	targets					891:897	two critical skin cell protein targets	860:897	two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	860:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	87	theme	skin	873:876	arg1	synthase-1					911:920	hyaluronan synthase-1	900:920	hyaluronan synthase-1 (HAS-1)	900:928	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	87	theme	skin	873:876	arg1	cluster					957:963	the HA binding protein cluster	934:963	the HA binding protein cluster of differentiation 44 (CD44)	934:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	6	88	theme	test	1378:1381	arg1	materials					1383:1391	the HA test materials	1371:1391	the HA test materials	1371:1391	RESULTS Examination of HAS-1 protein expression indicates that none of the HA test materials influenced the expression of HAS-1 at any concentration.
33908161	2	89	theme	cellular	459:466	arg1	proteins					468:475	important cellular proteins	449:475	important cellular proteins	449:475	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	4	90	theme	1.0	1038:1040	arg1	%					1041:1041	%	1041:1041	%	1041:1041	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	3	91	theme	average	690:696	arg1	AIMS					507:510	AIMS	507:510	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).	507:993	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	91	theme	average	690:696	arg1	Mw					698:699	3) average Mw	687:699	3) average Mw of the low fraction	687:719	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	0	92	theme	HAS1	81:84	arg1	proteins					86:93	HAS1 proteins	81:93	CD44 proteins but not HAS1 proteins	59:93	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	7	93	theme	high	1649:1652	arg1	fractions					1660:1668	high Mw HA fractions	1649:1668	high Mw HA fractions	1649:1668	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	8	94	theme	protein	1770:1776	arg1	expression					1751:1760	the expression	1747:1760	the expression of CD44 protein, a critical HA transmembrane HA binding protein,	1747:1825	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	2	95	theme	various	332:338	arg1	fragments					357:365	various molecular weight fragments	332:365	various molecular weight fragments of HA	332:371	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	3	96	theme	composite	750:758	arg1	complex					760:766	a unique 1:1:1 composite complex	735:766	a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid)	735:811	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	2	97	theme	human	383:387	arg1	NHEK					414:417	NHEK	414:417	NHEK	414:417	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	2	97	theme	human	383:387	arg1	keratinocytes					399:411	normal human epidermal keratinocytes	376:411	normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins	376:475	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	7	98	theme	protein	1474:1480	arg1	expression					1482:1491	the CD44 protein expression	1465:1491	the CD44 protein expression	1465:1491	Examination of the CD44 protein expression indicated that the low Mw fraction and the commercial complex of the three Mw fractions upregulated CD44 protein expression in NHEKs, but the medium Mw and high Mw HA fractions did not.
33908161	3	99	theme	fragments	784:792	arg1	complex					760:766	a unique 1:1:1 composite complex	735:766	a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid)	735:811	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	99	theme	fragments	784:792	arg1	5-10 kDa					722:729	5-10 kDa	722:729	5-10 kDa	722:729	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	8	100	theme	HA	1790:1791	arg1	protein					1818:1824	a critical HA transmembrane HA binding protein	1779:1824	a critical HA transmembrane HA binding protein	1779:1824	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	8	100	theme	HA	1790:1791	arg1	protein					1770:1776	CD44 protein	1765:1776	CD44 protein	1765:1776	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	4	101	theme	HA	1066:1067	arg1	fraction					1072:1079	each HA Mw fraction	1061:1079	each HA Mw fraction	1061:1079	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	1	102	theme	smaller	239:245	arg1	fragments					247:255	smaller fragments	239:255	smaller fragments	239:255	BACKGROUND In the skin, hyaluronic acid is broken down to smaller fragments by hyaluronidase enzymes, particularly when skin is wounded.
33908161	0	103	dep	in	36:37	arg1	vitro					39:43	vitro	39:43	vitro	39:43	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	8	104	theme	HA	1807:1808	arg1	protein					1818:1824	a critical HA transmembrane HA binding protein	1779:1824	a critical HA transmembrane HA binding protein	1779:1824	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	8	104	theme	HA	1807:1808	arg1	protein					1770:1776	CD44 protein	1765:1776	CD44 protein	1765:1776	CONCLUSIONS In this work, it was demonstrated that HA can influence the expression of CD44 protein, a critical HA transmembrane HA binding protein, and the influence appears to be molecular weight dependent.
33908161	5	105	theme	protein	1283:1289	arg1	content					1291:1297	CD44 protein content	1278:1297	CD44 protein content	1278:1297	The cells were than analyzed by ELISA protein assays for HAS-1 and CD44 protein content.
33908161	4	106	theme	fraction	1072:1079	arg1	solution					1049:1056	a 1.0% stock solution	1036:1056	a 1.0% stock solution of each HA Mw fraction	1036:1079	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	2	107	theme	weight	350:355	arg1	fragments					357:365	various molecular weight fragments	332:365	various molecular weight fragments of HA	332:371	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	0	108	theme	in	36:37	arg1	expression					45:54	the in vitro expression	32:54	the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs)	32:141	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	3	109	theme	protein	949:955	arg1	targets					891:897	two critical skin cell protein targets	860:897	two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	860:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	109	theme	protein	949:955	arg1	CD44					988:991	CD44	988:991	CD44	988:991	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	109	theme	protein	949:955	arg1	cluster					957:963	the HA binding protein cluster	934:963	the HA binding protein cluster of differentiation 44 (CD44)	934:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	2	110	from	impact	322:327	arg1	NHEK					414:417	NHEK	414:417	NHEK	414:417	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	2	110	from	impact	322:327	arg1	keratinocytes					399:411	normal human epidermal keratinocytes	376:411	normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins	376:475	The impact of various molecular weight fragments of HA on normal human epidermal keratinocytes (NHEK) with regard to expression of important cellular proteins has not been deeply explored.
33908161	3	111	from	HA	854:855	arg1	targets					891:897	two critical skin cell protein targets	860:897	two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	860:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	111	from	HA	854:855	arg1	synthase-1					911:920	hyaluronan synthase-1	900:920	hyaluronan synthase-1 (HAS-1)	900:928	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	111	from	HA	854:855	arg1	cluster					957:963	the HA binding protein cluster	934:963	the HA binding protein cluster of differentiation 44 (CD44)	934:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	5	112	theme	protein	1249:1255	arg1	assays					1257:1262	ELISA protein assays	1243:1262	ELISA protein assays for HAS-1 and CD44 protein content	1243:1297	The cells were than analyzed by ELISA protein assays for HAS-1 and CD44 protein content.
33908161	4	113	theme	stock	1043:1047	arg1	solution					1049:1056	a 1.0% stock solution	1036:1056	a 1.0% stock solution of each HA Mw fraction	1036:1079	METHODS NHEKs were treated in vitro with a 1.0% stock solution of each HA Mw fraction at 1.0, 0.5, and 0.1% concentrations of the 1.0% solution and the polysaccharide composite at the same concentrations for 48 Hrs.
33908161	0	114	from	expression	45:54	arg1	keratinocytes					121:133	normal human epidermal keratinocytes	98:133	normal human epidermal keratinocytes (NHEKs)	98:141	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	0	114	from	expression	45:54	arg1	NHEKs					136:140	NHEKs	136:140	NHEKs	136:140	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.
33908161	3	115	theme	HA	938:939	arg1	targets					891:897	two critical skin cell protein targets	860:897	two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44)	860:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	115	theme	HA	938:939	arg1	CD44					988:991	CD44	988:991	CD44	988:991	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	115	theme	HA	938:939	arg1	cluster					957:963	the HA binding protein cluster	934:963	the HA binding protein cluster of differentiation 44 (CD44)	934:992	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	116	theme	Triluronic®	795:805	arg1	Acid					807:810	Triluronic® Acid	795:810	Triluronic® Acid	795:810	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	116	theme	Triluronic®	795:805	arg1	fragments					784:792	the three HA fragments	771:792	the three HA fragments (Triluronic® Acid)	771:811	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33908161	3	117	theme	high	606:609	arg1	fraction					611:618	the high fraction	602:618	the high fraction	602:618	AIMS Examination of three molecular weight (Mw) fractions of hyaluronic acid: 1) average Mw of the high fraction: 1.5-2 MDa, 2) average Mw of the medium fraction: 200-500 kDa, and 3) average Mw of the low fraction: 5-10 kDa and a unique 1:1:1 composite complex of the three HA fragments (Triluronic® Acid) was done to examine the influence of the HA on two critical skin cell protein targets: hyaluronan synthase-1 (HAS-1) and the HA binding protein cluster of differentiation 44 (CD44).
33693758	4	0	theme	endogenous	621:630	arg1	peptides					632:639	endogenous peptides	621:639	endogenous peptides	621:639	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides, is required to fully understand the changing role of the human milk proteome throughout lactation.
33693758	10	1	theme	many	1377:1380	arg1	changes					1400:1406	many gradual and alike changes	1377:1406	many gradual and alike changes	1377:1406	We observed many gradual and alike changes in both donors related to temporal effects, for instance early lactation was marked by high concentrations of proteins and peptides involved in lactose synthesis and immune development.
33693758	8	2	theme	human	1114:1118	arg1	components					1139:1148	the human milk proteinaceous components	1110:1148	the human milk proteinaceous components	1110:1148	Comprehensive variations in the human milk proteinaceous components were assessed using quantitative LC-MS/MS methods.
33693758	2	3	theme	Personalized	285:296	arg1	strategies					317:326	Personalized proteome profiling strategies	285:326	Personalized proteome profiling strategies	285:326	Personalized proteome profiling strategies may provide insights into maternal-infant relationships.
33693758	1	4	theme	growing	269:275	arg1	infant					277:282	the growing infant	265:282	the growing infant	265:282	BACKGROUND Human milk is the most genuine form of personalized nutrition, whereby its nutritional and bioactive constituents support the changing needs of the growing infant.
33693758	8	5	theme	proteinaceous	1125:1137	arg1	components					1139:1148	the human milk proteinaceous components	1110:1148	the human milk proteinaceous components	1110:1148	Comprehensive variations in the human milk proteinaceous components were assessed using quantitative LC-MS/MS methods.
33693758	10	6	theme	peptides	1531:1538	arg1	concentrations					1500:1513	high concentrations	1495:1513	high concentrations of proteins and peptides involved in lactose synthesis and immune development	1495:1591	We observed many gradual and alike changes in both donors related to temporal effects, for instance early lactation was marked by high concentrations of proteins and peptides involved in lactose synthesis and immune development.
33693758	11	7	theme	donors	1618:1623	arg1	1					1607:1607	1	1607:1607	1	1607:1607	Uniquely, in 1 of the 2 donors, we observed a substantial anomaly in the milk composition, exclusively at week 6, likely indicating a response to inflammation and/or infection.
33693758	11	7	theme	donors	1618:1623	arg1	donors					1618:1623	the 2 donors	1612:1623	the 2 donors	1612:1623	Uniquely, in 1 of the 2 donors, we observed a substantial anomaly in the milk composition, exclusively at week 6, likely indicating a response to inflammation and/or infection.
33693758	0	8	theme	Personalized	0:11	arg1	Profiling					13:21	Personalized Profiling	0:21	Personalized Profiling	0:21	Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome.
33693758	1	9	theme	nutrition	173:181	arg1	form					152:155	the most genuine form	135:155	the most genuine form	135:155	BACKGROUND Human milk is the most genuine form of personalized nutrition, whereby its nutritional and bioactive constituents support the changing needs of the growing infant.
33693758	1	9	theme	nutrition	173:181	arg1	milk					127:130	BACKGROUND Human milk	110:130	BACKGROUND Human milk	110:130	BACKGROUND Human milk is the most genuine form of personalized nutrition, whereby its nutritional and bioactive constituents support the changing needs of the growing infant.
33693758	12	10	theme	endogenous	1921:1930	arg1	peptides					1932:1939	endogenous peptides	1921:1939	endogenous peptides	1921:1939	CONCLUSIONS Here, we provide a resource for characterizing the lactational changes in the human milk proteome, encompassing thousands of proteins and endogenous peptides.
33693758	4	11	theme	milk	705:708	arg1	proteome					710:717	the human milk proteome	695:717	the human milk proteome	695:717	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides, is required to fully understand the changing role of the human milk proteome throughout lactation.
33693758	10	12	theme	immune	1574:1579	arg1	development					1581:1591	immune development	1574:1591	immune development	1574:1591	We observed many gradual and alike changes in both donors related to temporal effects, for instance early lactation was marked by high concentrations of proteins and peptides involved in lactose synthesis and immune development.
33693758	2	13	theme	profiling	307:315	arg1	strategies					317:326	Personalized proteome profiling strategies	285:326	Personalized proteome profiling strategies	285:326	Personalized proteome profiling strategies may provide insights into maternal-infant relationships.
33693758	1	14	theme	nutritional	196:206	arg1	constituents					222:233	its nutritional and bioactive constituents	192:233	its nutritional and bioactive constituents	192:233	BACKGROUND Human milk is the most genuine form of personalized nutrition, whereby its nutritional and bioactive constituents support the changing needs of the growing infant.
33693758	8	15	theme	LC-MS/MS	1183:1190	arg1	methods					1192:1198	quantitative LC-MS/MS methods	1170:1198	quantitative LC-MS/MS methods	1170:1198	Comprehensive variations in the human milk proteinaceous components were assessed using quantitative LC-MS/MS methods.
33693758	13	16	theme	newborn	2079:2085	arg1	status					2110:2115	the health status	2099:2115	the health status of each individual mother-infant pair	2099:2153	Further, we demonstrate the feasibility and benefit of personalized profiling to monitor the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair.
33693758	13	16	theme	newborn	2079:2085	arg1	development					2060:2070	the development	2056:2070	the development of the newborn	2056:2085	Further, we demonstrate the feasibility and benefit of personalized profiling to monitor the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair.
33693758	1	17	theme	bioactive	212:220	arg1	constituents					222:233	its nutritional and bioactive constituents	192:233	its nutritional and bioactive constituents	192:233	BACKGROUND Human milk is the most genuine form of personalized nutrition, whereby its nutritional and bioactive constituents support the changing needs of the growing infant.
33693758	12	18	theme	proteins	1908:1915	arg1	thousands					1895:1903	thousands	1895:1903	thousands of proteins and endogenous peptides	1895:1939	CONCLUSIONS Here, we provide a resource for characterizing the lactational changes in the human milk proteome, encompassing thousands of proteins and endogenous peptides.
33693758	6	19	dep	METHODS	876:882	arg1	donors					912:917	Two individual healthy milk donors	884:917	Two individual healthy milk donors	884:917	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	6	19	dep	METHODS	876:882	arg1	y					935:935	29 and 32 y	925:935	29 and 32 y	925:935	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	6	19	dep	METHODS	876:882	arg1	BMI					958:960	a normal BMI	949:960	a normal BMI	949:960	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	6	19	dep	METHODS	876:882	arg1	both					941:944	both	941:944	both	941:944	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	13	20	theme	milk	2048:2051	arg1	influence					2035:2043	the influence	2031:2043	the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair	2031:2153	Further, we demonstrate the feasibility and benefit of personalized profiling to monitor the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair.
33693758	6	21	theme	normal	951:956	arg1	BMI					958:960	a normal BMI	949:960	a normal BMI	949:960	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	9	22	theme	milk	1264:1267	arg1	proteins					1269:1276	>1300 milk proteins	1258:1276	>1300 milk proteins	1258:1276	RESULTS We longitudinally profiled the concentrations of >1300 milk proteins and 2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors.
33693758	1	23	theme	genuine	144:150	arg1	form					152:155	the most genuine form	135:155	the most genuine form	135:155	BACKGROUND Human milk is the most genuine form of personalized nutrition, whereby its nutritional and bioactive constituents support the changing needs of the growing infant.
33693758	1	23	theme	genuine	144:150	arg1	milk					127:130	BACKGROUND Human milk	110:130	BACKGROUND Human milk	110:130	BACKGROUND Human milk is the most genuine form of personalized nutrition, whereby its nutritional and bioactive constituents support the changing needs of the growing infant.
33693758	5	24	dep	OBJECTIVE	741:749	arg1	aimed					754:758	aimed	754:758	aimed to investigate the personalized nature of the human milk proteome and peptidome for individual mother-infant dyads	754:873	OBJECTIVE We aimed to investigate the personalized nature of the human milk proteome and peptidome for individual mother-infant dyads.
33693758	10	25	theme	related	1423:1429	arg1	donors					1416:1421	both donors	1411:1421	both donors related to temporal effects	1411:1449	We observed many gradual and alike changes in both donors related to temporal effects, for instance early lactation was marked by high concentrations of proteins and peptides involved in lactose synthesis and immune development.
33693758	0	26	theme	Milk	81:84	arg1	Proteome					86:93	the Human Milk Proteome	71:93	the Human Milk Proteome	71:93	Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome.
33693758	12	27	theme	human	1861:1865	arg1	proteome					1872:1879	the human milk proteome	1857:1879	the human milk proteome	1857:1879	CONCLUSIONS Here, we provide a resource for characterizing the lactational changes in the human milk proteome, encompassing thousands of proteins and endogenous peptides.
33693758	9	28	theme	endogenous	1287:1296	arg1	peptides					1303:1310	2000 endogenous milk peptides	1282:1310	2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors	1282:1362	RESULTS We longitudinally profiled the concentrations of >1300 milk proteins and 2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors.
33693758	11	29	from	anomaly	1652:1658	arg1	composition					1672:1682	the milk composition	1663:1682	the milk composition	1663:1682	Uniquely, in 1 of the 2 donors, we observed a substantial anomaly in the milk composition, exclusively at week 6, likely indicating a response to inflammation and/or infection.
33693758	0	30	from	Trends	61:66	arg1	Peptidome					99:107	Peptidome	99:107	Peptidome	99:107	Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome.
33693758	0	30	from	Trends	61:66	arg1	Proteome					86:93	the Human Milk Proteome	71:93	the Human Milk Proteome	71:93	Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome.
33693758	9	31	theme	peptides	1303:1310	arg1	concentrations					1240:1253	the concentrations	1236:1253	the concentrations of >1300 milk proteins and 2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors	1236:1362	RESULTS We longitudinally profiled the concentrations of >1300 milk proteins and 2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors.
33693758	0	32	theme	Lactation-Specific	42:59	arg1	Trends					61:66	Donor- and Lactation-Specific Trends	31:66	Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome	31:107	Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome.
33693758	3	33	theme	human	421:425	arg1	milk					427:430	human milk	421:430	human milk	421:430	Proteins and endogenous peptides in human milk play an important role as nutrients for growth and have distinct functionality such as immune defense.
33693758	10	34	theme	temporal	1434:1441	arg1	effects					1443:1449	temporal effects	1434:1449	temporal effects	1434:1449	We observed many gradual and alike changes in both donors related to temporal effects, for instance early lactation was marked by high concentrations of proteins and peptides involved in lactose synthesis and immune development.
33693758	5	35	theme	mother-infant	855:867	arg1	dyads					869:873	individual mother-infant dyads	844:873	individual mother-infant dyads	844:873	OBJECTIVE We aimed to investigate the personalized nature of the human milk proteome and peptidome for individual mother-infant dyads.
33693758	4	36	theme	milk	580:583	arg1	peptides					632:639	endogenous peptides	621:639	endogenous peptides	621:639	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides, is required to fully understand the changing role of the human milk proteome throughout lactation.
33693758	4	36	theme	milk	580:583	arg1	components					599:608	the human milk proteinaceous components	570:608	the human milk proteinaceous components	570:608	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides, is required to fully understand the changing role of the human milk proteome throughout lactation.
33693758	12	37	dep	CONCLUSIONS	1771:1781	arg1	provide					1792:1798	provide	1792:1798	provide	1792:1798	CONCLUSIONS Here, we provide a resource for characterizing the lactational changes in the human milk proteome, encompassing thousands of proteins and endogenous peptides.
33693758	3	38	theme	distinct	488:495	arg1	functionality					497:509	distinct functionality	488:509	distinct functionality	488:509	Proteins and endogenous peptides in human milk play an important role as nutrients for growth and have distinct functionality such as immune defense.
33693758	6	39	theme	aged	920:923	arg1	donors					912:917	Two individual healthy milk donors	884:917	Two individual healthy milk donors	884:917	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	6	39	theme	aged	920:923	arg1	y					935:935	29 and 32 y	925:935	29 and 32 y	925:935	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	1	40	theme	BACKGROUND	110:119	arg1	form					152:155	the most genuine form	135:155	the most genuine form	135:155	BACKGROUND Human milk is the most genuine form of personalized nutrition, whereby its nutritional and bioactive constituents support the changing needs of the growing infant.
33693758	1	40	theme	BACKGROUND	110:119	arg1	milk					127:130	BACKGROUND Human milk	110:130	BACKGROUND Human milk	110:130	BACKGROUND Human milk is the most genuine form of personalized nutrition, whereby its nutritional and bioactive constituents support the changing needs of the growing infant.
33693758	3	41	theme	important	440:448	arg1	nutrients					458:466	nutrients	458:466	nutrients for growth	458:477	Proteins and endogenous peptides in human milk play an important role as nutrients for growth and have distinct functionality such as immune defense.
33693758	3	41	theme	important	440:448	arg1	role					450:453	an important role	437:453	an important role	437:453	Proteins and endogenous peptides in human milk play an important role as nutrients for growth and have distinct functionality such as immune defense.
33693758	13	42	theme	individual	2125:2134	arg1	pair					2150:2153	each individual mother-infant pair	2120:2153	each individual mother-infant pair	2120:2153	Further, we demonstrate the feasibility and benefit of personalized profiling to monitor the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair.
33693758	4	43	theme	all	563:565	arg1	monitoring					549:558	Comprehensive monitoring	535:558	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides,	535:640	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides, is required to fully understand the changing role of the human milk proteome throughout lactation.
33693758	10	44	theme	high	1495:1498	arg1	concentrations					1500:1513	high concentrations	1495:1513	high concentrations of proteins and peptides involved in lactose synthesis and immune development	1495:1591	We observed many gradual and alike changes in both donors related to temporal effects, for instance early lactation was marked by high concentrations of proteins and peptides involved in lactose synthesis and immune development.
33693758	11	45	theme	substantial	1640:1650	arg1	anomaly					1652:1658	a substantial anomaly	1638:1658	a substantial anomaly in the milk composition	1638:1682	Uniquely, in 1 of the 2 donors, we observed a substantial anomaly in the milk composition, exclusively at week 6, likely indicating a response to inflammation and/or infection.
33693758	3	46	theme	immune	519:524	arg1	defense					526:532	immune defense	519:532	immune defense	519:532	Proteins and endogenous peptides in human milk play an important role as nutrients for growth and have distinct functionality such as immune defense.
33693758	9	47	theme	individual	1346:1355	arg1	donors					1357:1362	2 individual donors	1344:1362	2 individual donors	1344:1362	RESULTS We longitudinally profiled the concentrations of >1300 milk proteins and 2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors.
33693758	6	48	theme	healthy	899:905	arg1	donors					912:917	Two individual healthy milk donors	884:917	Two individual healthy milk donors	884:917	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	6	48	theme	healthy	899:905	arg1	y					935:935	29 and 32 y	925:935	29 and 32 y	925:935	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	6	48	theme	healthy	899:905	arg1	BMI					958:960	a normal BMI	949:960	a normal BMI	949:960	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	6	48	theme	healthy	899:905	arg1	both					941:944	both	941:944	both	941:944	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	13	49	theme	health	2103:2108	arg1	status					2110:2115	the health status	2099:2115	the health status of each individual mother-infant pair	2099:2153	Further, we demonstrate the feasibility and benefit of personalized profiling to monitor the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair.
33693758	11	50	theme	milk	1667:1670	arg1	composition					1672:1682	the milk composition	1663:1682	the milk composition	1663:1682	Uniquely, in 1 of the 2 donors, we observed a substantial anomaly in the milk composition, exclusively at week 6, likely indicating a response to inflammation and/or infection.
33693758	10	51	theme	lactose	1552:1558	arg1	synthesis					1560:1568	lactose synthesis	1552:1568	lactose synthesis	1552:1568	We observed many gradual and alike changes in both donors related to temporal effects, for instance early lactation was marked by high concentrations of proteins and peptides involved in lactose synthesis and immune development.
33693758	7	52	theme	Milk	1048:1051	arg1	collection					1053:1062	Milk collection	1048:1062	Milk collection	1048:1062	Milk collection was standardized.
33693758	2	53	theme	proteome	298:305	arg1	strategies					317:326	Personalized proteome profiling strategies	285:326	Personalized proteome profiling strategies	285:326	Personalized proteome profiling strategies may provide insights into maternal-infant relationships.
33693758	1	54	theme	personalized	160:171	arg1	nutrition					173:181	personalized nutrition	160:181	personalized nutrition	160:181	BACKGROUND Human milk is the most genuine form of personalized nutrition, whereby its nutritional and bioactive constituents support the changing needs of the growing infant.
33693758	8	55	theme	milk	1120:1123	arg1	components					1139:1148	the human milk proteinaceous components	1110:1148	the human milk proteinaceous components	1110:1148	Comprehensive variations in the human milk proteinaceous components were assessed using quantitative LC-MS/MS methods.
33693758	13	56	theme	pair	2150:2153	arg1	status					2110:2115	the health status	2099:2115	the health status of each individual mother-infant pair	2099:2153	Further, we demonstrate the feasibility and benefit of personalized profiling to monitor the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair.
33693758	13	56	theme	pair	2150:2153	arg1	development					2060:2070	the development	2056:2070	the development of the newborn	2056:2085	Further, we demonstrate the feasibility and benefit of personalized profiling to monitor the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair.
33693758	5	57	theme	milk	812:815	arg1	proteome					817:824	the human milk proteome	802:824	the human milk proteome	802:824	OBJECTIVE We aimed to investigate the personalized nature of the human milk proteome and peptidome for individual mother-infant dyads.
33693758	10	58	theme	alike	1394:1398	arg1	changes					1400:1406	many gradual and alike changes	1377:1406	many gradual and alike changes	1377:1406	We observed many gradual and alike changes in both donors related to temporal effects, for instance early lactation was marked by high concentrations of proteins and peptides involved in lactose synthesis and immune development.
33693758	6	59	theme	weeks	997:1001	arg1	postpartum					1036:1045	weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum	997:1045	weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum	997:1045	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	4	60	theme	human	699:703	arg1	proteome					710:717	the human milk proteome	695:717	the human milk proteome	695:717	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides, is required to fully understand the changing role of the human milk proteome throughout lactation.
33693758	10	61	theme	gradual	1382:1388	arg1	changes					1400:1406	many gradual and alike changes	1377:1406	many gradual and alike changes	1377:1406	We observed many gradual and alike changes in both donors related to temporal effects, for instance early lactation was marked by high concentrations of proteins and peptides involved in lactose synthesis and immune development.
33693758	12	62	theme	peptides	1932:1939	arg1	thousands					1895:1903	thousands	1895:1903	thousands of proteins and endogenous peptides	1895:1939	CONCLUSIONS Here, we provide a resource for characterizing the lactational changes in the human milk proteome, encompassing thousands of proteins and endogenous peptides.
33693758	3	63	contain	have	483:486	arg2	functionality					497:509	distinct functionality	488:509	distinct functionality	488:509	Proteins and endogenous peptides in human milk play an important role as nutrients for growth and have distinct functionality such as immune defense.
33693758	3	63	contain	have	483:486	arg1	Proteins					385:392	Proteins	385:392	Proteins	385:392	Proteins and endogenous peptides in human milk play an important role as nutrients for growth and have distinct functionality such as immune defense.
33693758	13	64	from	influence	2035:2043	arg1	status					2110:2115	the health status	2099:2115	the health status of each individual mother-infant pair	2099:2153	Further, we demonstrate the feasibility and benefit of personalized profiling to monitor the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair.
33693758	13	64	from	influence	2035:2043	arg1	development					2060:2070	the development	2056:2070	the development of the newborn	2056:2085	Further, we demonstrate the feasibility and benefit of personalized profiling to monitor the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair.
33693758	3	65	from	Proteins	385:392	arg1	milk					427:430	human milk	421:430	human milk	421:430	Proteins and endogenous peptides in human milk play an important role as nutrients for growth and have distinct functionality such as immune defense.
33693758	8	66	theme	quantitative	1170:1181	arg1	methods					1192:1198	quantitative LC-MS/MS methods	1170:1198	quantitative LC-MS/MS methods	1170:1198	Comprehensive variations in the human milk proteinaceous components were assessed using quantitative LC-MS/MS methods.
33693758	4	67	theme	changing	678:685	arg1	role					687:690	the changing role	674:690	the changing role of the human milk proteome throughout lactation	674:738	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides, is required to fully understand the changing role of the human milk proteome throughout lactation.
33693758	1	68	theme	Human	121:125	arg1	form					152:155	the most genuine form	135:155	the most genuine form	135:155	BACKGROUND Human milk is the most genuine form of personalized nutrition, whereby its nutritional and bioactive constituents support the changing needs of the growing infant.
33693758	1	68	theme	Human	121:125	arg1	milk					127:130	BACKGROUND Human milk	110:130	BACKGROUND Human milk	110:130	BACKGROUND Human milk is the most genuine form of personalized nutrition, whereby its nutritional and bioactive constituents support the changing needs of the growing infant.
33693758	0	69	theme	Human	75:79	arg1	Proteome					86:93	the Human Milk Proteome	71:93	the Human Milk Proteome	71:93	Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome.
33693758	9	70	theme	>1300	1258:1262	arg1	proteins					1269:1276	>1300 milk proteins	1258:1276	>1300 milk proteins	1258:1276	RESULTS We longitudinally profiled the concentrations of >1300 milk proteins and 2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors.
33693758	4	71	theme	Comprehensive	535:547	arg1	monitoring					549:558	Comprehensive monitoring	535:558	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides,	535:640	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides, is required to fully understand the changing role of the human milk proteome throughout lactation.
33693758	4	72	theme	proteome	710:717	arg1	role					687:690	the changing role	674:690	the changing role of the human milk proteome throughout lactation	674:738	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides, is required to fully understand the changing role of the human milk proteome throughout lactation.
33693758	5	73	theme	human	806:810	arg1	proteome					817:824	the human milk proteome	802:824	the human milk proteome	802:824	OBJECTIVE We aimed to investigate the personalized nature of the human milk proteome and peptidome for individual mother-infant dyads.
33693758	9	74	theme	proteins	1269:1276	arg1	concentrations					1240:1253	the concentrations	1236:1253	the concentrations of >1300 milk proteins and 2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors	1236:1362	RESULTS We longitudinally profiled the concentrations of >1300 milk proteins and 2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors.
33693758	12	75	theme	milk	1867:1870	arg1	proteome					1872:1879	the human milk proteome	1857:1879	the human milk proteome	1857:1879	CONCLUSIONS Here, we provide a resource for characterizing the lactational changes in the human milk proteome, encompassing thousands of proteins and endogenous peptides.
33693758	3	76	from	peptides	409:416	arg1	milk					427:430	human milk	421:430	human milk	421:430	Proteins and endogenous peptides in human milk play an important role as nutrients for growth and have distinct functionality such as immune defense.
33693758	1	77	dep	the	243:245	arg1	needs					256:260	needs	256:260	needs	256:260	BACKGROUND Human milk is the most genuine form of personalized nutrition, whereby its nutritional and bioactive constituents support the changing needs of the growing infant.
33693758	12	78	from	changes	1846:1852	arg1	proteome					1872:1879	the human milk proteome	1857:1879	the human milk proteome	1857:1879	CONCLUSIONS Here, we provide a resource for characterizing the lactational changes in the human milk proteome, encompassing thousands of proteins and endogenous peptides.
33693758	3	79	theme	endogenous	398:407	arg1	peptides					409:416	endogenous peptides	398:416	endogenous peptides	398:416	Proteins and endogenous peptides in human milk play an important role as nutrients for growth and have distinct functionality such as immune defense.
33693758	5	80	theme	personalized	779:790	arg1	nature					792:797	the personalized nature	775:797	the personalized nature of the human milk proteome	775:824	OBJECTIVE We aimed to investigate the personalized nature of the human milk proteome and peptidome for individual mother-infant dyads.
33693758	9	81	theme	milk	1298:1301	arg1	peptides					1303:1310	2000 endogenous milk peptides	1282:1310	2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors	1282:1362	RESULTS We longitudinally profiled the concentrations of >1300 milk proteins and 2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors.
33693758	5	82	theme	individual	844:853	arg1	dyads					869:873	individual mother-infant dyads	844:873	individual mother-infant dyads	844:873	OBJECTIVE We aimed to investigate the personalized nature of the human milk proteome and peptidome for individual mother-infant dyads.
33693758	13	83	theme	personalized	1997:2008	arg1	profiling					2010:2018	personalized profiling	1997:2018	personalized profiling	1997:2018	Further, we demonstrate the feasibility and benefit of personalized profiling to monitor the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair.
33693758	4	84	theme	proteinaceous	585:597	arg1	peptides					632:639	endogenous peptides	621:639	endogenous peptides	621:639	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides, is required to fully understand the changing role of the human milk proteome throughout lactation.
33693758	4	84	theme	proteinaceous	585:597	arg1	components					599:608	the human milk proteinaceous components	570:608	the human milk proteinaceous components	570:608	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides, is required to fully understand the changing role of the human milk proteome throughout lactation.
33693758	0	85	theme	Donor-	31:36	arg1	Trends					61:66	Donor- and Lactation-Specific Trends	31:66	Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome	31:107	Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome.
33693758	10	86	theme	early	1465:1469	arg1	lactation					1471:1479	early lactation	1465:1479	early lactation	1465:1479	We observed many gradual and alike changes in both donors related to temporal effects, for instance early lactation was marked by high concentrations of proteins and peptides involved in lactose synthesis and immune development.
33693758	5	87	theme	proteome	817:824	arg1	peptidome					830:838	peptidome	830:838	peptidome for individual mother-infant dyads	830:873	OBJECTIVE We aimed to investigate the personalized nature of the human milk proteome and peptidome for individual mother-infant dyads.
33693758	5	87	theme	proteome	817:824	arg1	nature					792:797	the personalized nature	775:797	the personalized nature of the human milk proteome	775:824	OBJECTIVE We aimed to investigate the personalized nature of the human milk proteome and peptidome for individual mother-infant dyads.
33693758	9	88	theme	lactation	1330:1338	arg1	wk					1324:1325	16 wk	1321:1325	16 wk of lactation for 2 individual donors	1321:1362	RESULTS We longitudinally profiled the concentrations of >1300 milk proteins and 2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors.
33693758	8	89	from	variations	1096:1105	arg1	components					1139:1148	the human milk proteinaceous components	1110:1148	the human milk proteinaceous components	1110:1148	Comprehensive variations in the human milk proteinaceous components were assessed using quantitative LC-MS/MS methods.
33693758	13	90	theme	mother-infant	2136:2148	arg1	pair					2150:2153	each individual mother-infant pair	2120:2153	each individual mother-infant pair	2120:2153	Further, we demonstrate the feasibility and benefit of personalized profiling to monitor the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair.
33693758	6	91	theme	milk	907:910	arg1	donors					912:917	Two individual healthy milk donors	884:917	Two individual healthy milk donors	884:917	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	6	91	theme	milk	907:910	arg1	y					935:935	29 and 32 y	925:935	29 and 32 y	925:935	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	6	91	theme	milk	907:910	arg1	BMI					958:960	a normal BMI	949:960	a normal BMI	949:960	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	6	91	theme	milk	907:910	arg1	both					941:944	both	941:944	both	941:944	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	13	92	theme	profiling	2010:2018	arg1	feasibility					1970:1980	feasibility	1970:1980	feasibility	1970:1980	Further, we demonstrate the feasibility and benefit of personalized profiling to monitor the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair.
33693758	13	92	theme	profiling	2010:2018	arg1	benefit					1986:1992	benefit	1986:1992	benefit	1986:1992	Further, we demonstrate the feasibility and benefit of personalized profiling to monitor the influence of milk on the development of the newborn, as well as the health status of each individual mother-infant pair.
33693758	4	93	theme	human	574:578	arg1	peptides					632:639	endogenous peptides	621:639	endogenous peptides	621:639	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides, is required to fully understand the changing role of the human milk proteome throughout lactation.
33693758	4	93	theme	human	574:578	arg1	components					599:608	the human milk proteinaceous components	570:608	the human milk proteinaceous components	570:608	Comprehensive monitoring of all of the human milk proteinaceous components, including endogenous peptides, is required to fully understand the changing role of the human milk proteome throughout lactation.
33693758	12	94	theme	lactational	1834:1844	arg1	changes					1846:1852	the lactational changes	1830:1852	the lactational changes in the human milk proteome	1830:1879	CONCLUSIONS Here, we provide a resource for characterizing the lactational changes in the human milk proteome, encompassing thousands of proteins and endogenous peptides.
33693758	2	95	theme	maternal-infant	354:368	arg1	relationships					370:382	maternal-infant relationships	354:382	maternal-infant relationships	354:382	Personalized proteome profiling strategies may provide insights into maternal-infant relationships.
33693758	6	96	theme	individual	888:897	arg1	donors					912:917	Two individual healthy milk donors	884:917	Two individual healthy milk donors	884:917	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	6	96	theme	individual	888:897	arg1	y					935:935	29 and 32 y	925:935	29 and 32 y	925:935	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	6	96	theme	individual	888:897	arg1	BMI					958:960	a normal BMI	949:960	a normal BMI	949:960	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	6	96	theme	individual	888:897	arg1	both					941:944	both	941:944	both	941:944	METHODS Two individual healthy milk donors, aged 29 and 32 y and both of a normal BMI, were longitudinally observed over weeks 1, 2, 3, 4, 6, 8, 10, 12, and 16 postpartum.
33693758	8	97	theme	Comprehensive	1082:1094	arg1	variations					1096:1105	Comprehensive variations	1082:1105	Comprehensive variations in the human milk proteinaceous components	1082:1148	Comprehensive variations in the human milk proteinaceous components were assessed using quantitative LC-MS/MS methods.
33693758	9	98	dep	RESULTS	1201:1207	arg1	profiled					1227:1234	profiled	1227:1234	profiled the concentrations of >1300 milk proteins and 2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors	1227:1362	RESULTS We longitudinally profiled the concentrations of >1300 milk proteins and 2000 endogenous milk peptides spanning 16 wk of lactation for 2 individual donors.
33693758	10	99	theme	proteins	1518:1525	arg1	concentrations					1500:1513	high concentrations	1495:1513	high concentrations of proteins and peptides involved in lactose synthesis and immune development	1495:1591	We observed many gradual and alike changes in both donors related to temporal effects, for instance early lactation was marked by high concentrations of proteins and peptides involved in lactose synthesis and immune development.
33805785	10	0	dep	In	1505:1506	arg1	vitro					1508:1512	vitro	1508:1512	vitro	1508:1512	In vitro RAL release profiles were investigated for 12 weeks and studied using UV/Vis spectroscopy.
33805785	2	1	theme	high	344:347	arg1	resemblance					349:359	their high resemblance	338:359	their high resemblance to bone mineral, their non-toxicity, and their affinity to ionic modifications and increasing osteogenic properties	338:475	In the treatment of bone defects, materials based on calcium phosphates (CaPs) are used due to their high resemblance to bone mineral, their non-toxicity, and their affinity to ionic modifications and increasing osteogenic properties.
33805785	15	2	theme	keratin	2160:2166	arg1	mixture					2124:2130	a mixture	2122:2130	a mixture of chondroitin sulphate and keratin	2122:2166	Based on the results, it was possible to select the optimal bead composition, consisting of a mixture of chondroitin sulphate and keratin.
33805785	5	3	dep	ions	774:777	arg1	Si-HA					783:787	Si-HA	783:787	Si-HA	783:787	HA powder, modified with magnesium and silicon ions (Mg,Si-HA) (both of which play beneficial roles in bone formation), was used to prepare composite beads.
33805785	5	3	dep	ions	774:777	arg1	Mg					780:781	Mg	780:781	Mg	780:781	HA powder, modified with magnesium and silicon ions (Mg,Si-HA) (both of which play beneficial roles in bone formation), was used to prepare composite beads.
33805785	8	4	dep	morphology	1167:1176	arg1	The					1163:1165	The	1163:1165	The	1163:1165	The morphology and porosity of three different types of beads obtained in this work were characterized by scanning electron microscopy (SEM) and mercury intrusion porosimetry, respectively.
33805785	2	5	theme	calcium	296:302	arg1	CaPs					316:319	CaPs	316:319	CaPs	316:319	In the treatment of bone defects, materials based on calcium phosphates (CaPs) are used due to their high resemblance to bone mineral, their non-toxicity, and their affinity to ionic modifications and increasing osteogenic properties.
33805785	2	5	theme	calcium	296:302	arg1	phosphates					304:313	calcium phosphates	296:313	calcium phosphates (CaPs)	296:320	In the treatment of bone defects, materials based on calcium phosphates (CaPs) are used due to their high resemblance to bone mineral, their non-toxicity, and their affinity to ionic modifications and increasing osteogenic properties.
33805785	15	6	theme	sulphate	2147:2154	arg1	mixture					2124:2130	a mixture	2122:2130	a mixture of chondroitin sulphate and keratin	2122:2166	Based on the results, it was possible to select the optimal bead composition, consisting of a mixture of chondroitin sulphate and keratin.
33805785	14	7	theme	burst	2008:2012	arg1	release					2014:2020	no burst release	2005:2020	no burst release effect	2005:2027	Results revealed that these beads possessed the most sustained drug release and no burst release effect.
33805785	13	8	theme	chondroitin	1806:1816	arg1	sulphate					1818:1825	chondroitin sulphate	1806:1825	chondroitin sulphate	1806:1825	The beads based on chondroitin sulphate and keratin (CS/KER-RAL) with the lowest porosity resulted in the highest resistance to crushing.
33805785	11	9	theme	cell	1695:1698	arg1	lines					1700:1704	osteosarcoma cell lines	1682:1704	osteosarcoma cell lines	1682:1704	The beads were also subjected to in vitro biological tests on osteoblast and osteosarcoma cell lines.
33805785	5	10	theme	beneficial	810:819	arg1	roles					821:825	beneficial roles	810:825	beneficial roles	810:825	HA powder, modified with magnesium and silicon ions (Mg,Si-HA) (both of which play beneficial roles in bone formation), was used to prepare composite beads.
33805785	3	11	used	used	546:549	arg2	vehicle					556:562	a vehicle	554:562	a vehicle for local drug delivery	554:586	Moreover, CaPs, especially hydroxyapatite (HA), can be successfully used as a vehicle for local drug delivery.
33805785	3	11	used	used	546:549	arg2	hydroxyapatite					505:518	hydroxyapatite	505:518	especially hydroxyapatite (HA)	494:523	Moreover, CaPs, especially hydroxyapatite (HA), can be successfully used as a vehicle for local drug delivery.
33805785	3	11	used	used	546:549	arg2	CaPs					488:491	CaPs	488:491	CaPs	488:491	Moreover, CaPs, especially hydroxyapatite (HA), can be successfully used as a vehicle for local drug delivery.
33805785	1	12	theme	fracture	222:229	arg1	likelihood					231:240	fracture likelihood	222:240	fracture likelihood	222:240	Osteoporosis is a worldwide chronic disease characterized by increasing bone fragility and fracture likelihood.
33805785	4	13	theme	potential	679:687	arg1	use					689:691	potential use	679:691	potential use as local carriers for raloxifene	679:724	Therefore, the aim of this work was to fabricate hydroxyapatite-based composite beads for potential use as local carriers for raloxifene.
33805785	7	14	from	concentration	1108:1120	arg1	surface					1154:1160	the material surface	1141:1160	the material surface	1141:1160	Cross-linking of beads containing raloxifene hydrochloride (RAL) was carried out with Mg ions in order to additionally increase the concentration of this element on the material surface.
33805785	10	15	theme	RAL	1514:1516	arg1	profiles					1526:1533	In vitro RAL release profiles	1505:1533	In vitro RAL release profiles	1505:1533	In vitro RAL release profiles were investigated for 12 weeks and studied using UV/Vis spectroscopy.
33805785	11	16	dep	in	1638:1639	arg1	vitro					1641:1645	vitro	1641:1645	vitro	1641:1645	The beads were also subjected to in vitro biological tests on osteoblast and osteosarcoma cell lines.
33805785	3	17	theme	drug	574:577	arg1	delivery					579:586	local drug delivery	568:586	local drug delivery	568:586	Moreover, CaPs, especially hydroxyapatite (HA), can be successfully used as a vehicle for local drug delivery.
33805785	9	18	theme	Mg	1385:1386	arg1	powder					1394:1399	the Mg,Si-HA powder	1381:1399	powder	1394:1399	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	8	19	theme	types	1210:1214	arg1	porosity					1182:1189	porosity	1182:1189	porosity	1182:1189	The morphology and porosity of three different types of beads obtained in this work were characterized by scanning electron microscopy (SEM) and mercury intrusion porosimetry, respectively.
33805785	8	19	theme	types	1210:1214	arg1	morphology					1167:1176	morphology	1167:1176	morphology	1167:1176	The morphology and porosity of three different types of beads obtained in this work were characterized by scanning electron microscopy (SEM) and mercury intrusion porosimetry, respectively.
33805785	10	20	theme	In	1505:1506	arg1	profiles					1526:1533	In vitro RAL release profiles	1505:1533	In vitro RAL release profiles	1505:1533	In vitro RAL release profiles were investigated for 12 weeks and studied using UV/Vis spectroscopy.
33805785	15	21	theme	optimal	2082:2088	arg1	composition					2095:2105	the optimal bead composition	2078:2105	the optimal bead composition	2078:2105	Based on the results, it was possible to select the optimal bead composition, consisting of a mixture of chondroitin sulphate and keratin.
33805785	4	22	theme	local	696:700	arg1	carriers					702:709	local carriers	696:709	local carriers for raloxifene	696:724	Therefore, the aim of this work was to fabricate hydroxyapatite-based composite beads for potential use as local carriers for raloxifene.
33805785	9	23	theme	emission	1472:1479	arg1	ICP-OES					1495:1501	ICP-OES	1495:1501	ICP-OES	1495:1501	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	9	23	theme	emission	1472:1479	arg1	spectrometry					1481:1492	inductively coupled plasma optical emission spectrometry	1437:1492	inductively coupled plasma optical emission spectrometry (ICP-OES)	1437:1502	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	11	24	theme	in	1638:1639	arg1	tests					1658:1662	in vitro biological tests	1638:1662	in vitro biological tests on osteoblast and osteosarcoma cell lines	1638:1704	The beads were also subjected to in vitro biological tests on osteoblast and osteosarcoma cell lines.
33805785	8	25	theme	beads	1219:1223	arg1	types					1210:1214	three different types	1194:1214	three different types of beads obtained in this work	1194:1245	The morphology and porosity of three different types of beads obtained in this work were characterized by scanning electron microscopy (SEM) and mercury intrusion porosimetry, respectively.
33805785	6	26	with	alginate	913:920	arg1	keratin					955:961	keratin	955:961	keratin	955:961	As an organic matrix, sodium alginate with chondroitin sulphate and/or keratin was applied.
33805785	6	26	with	alginate	913:920	arg1	sulphate					939:946	chondroitin sulphate	927:946	chondroitin sulphate	927:946	As an organic matrix, sodium alginate with chondroitin sulphate and/or keratin was applied.
33805785	4	27	theme	composite	659:667	arg1	beads					669:673	hydroxyapatite-based composite beads	638:673	hydroxyapatite-based composite beads	638:673	Therefore, the aim of this work was to fabricate hydroxyapatite-based composite beads for potential use as local carriers for raloxifene.
33805785	7	28	theme	material	1145:1152	arg1	surface					1154:1160	the material surface	1141:1160	the material surface	1141:1160	Cross-linking of beads containing raloxifene hydrochloride (RAL) was carried out with Mg ions in order to additionally increase the concentration of this element on the material surface.
33805785	2	29	theme	bone	263:266	arg1	defects					268:274	bone defects	263:274	bone defects	263:274	In the treatment of bone defects, materials based on calcium phosphates (CaPs) are used due to their high resemblance to bone mineral, their non-toxicity, and their affinity to ionic modifications and increasing osteogenic properties.
33805785	1	30	theme	chronic	159:165	arg1	disease					167:173	a worldwide chronic disease	147:173	a worldwide chronic disease characterized by increasing bone fragility and fracture likelihood	147:240	Osteoporosis is a worldwide chronic disease characterized by increasing bone fragility and fracture likelihood.
33805785	1	30	theme	chronic	159:165	arg1	Osteoporosis					131:142	Osteoporosis	131:142	Osteoporosis	131:142	Osteoporosis is a worldwide chronic disease characterized by increasing bone fragility and fracture likelihood.
33805785	0	31	theme	Potential	88:96	arg1	Use					98:100	Potential Use	88:100	Potential Use in Bone Tissue Regeneration	88:128	Mg,Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads Loaded with Raloxifene for Potential Use in Bone Tissue Regeneration.
33805785	6	32	theme	sodium	906:911	arg1	matrix					898:903	an organic matrix	887:903	an organic matrix	887:903	As an organic matrix, sodium alginate with chondroitin sulphate and/or keratin was applied.
33805785	6	32	theme	sodium	906:911	arg1	alginate					913:920	sodium alginate	906:920	sodium alginate with chondroitin sulphate and/or keratin	906:961	As an organic matrix, sodium alginate with chondroitin sulphate and/or keratin was applied.
33805785	9	33	dep	powder	1394:1399	arg1	Si-HA					1388:1392	the Mg,Si-HA powder	1381:1399	Si-HA	1388:1392	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	11	34	theme	biological	1647:1656	arg1	tests					1658:1662	in vitro biological tests	1638:1662	in vitro biological tests on osteoblast and osteosarcoma cell lines	1638:1704	The beads were also subjected to in vitro biological tests on osteoblast and osteosarcoma cell lines.
33805785	14	35	theme	sustained	1978:1986	arg1	release					1993:1999	the most sustained drug release	1969:1999	the most sustained drug release	1969:1999	Results revealed that these beads possessed the most sustained drug release and no burst release effect.
33805785	8	36	theme	scanning	1269:1276	arg1	microscopy					1287:1296	scanning electron microscopy	1269:1296	scanning electron microscopy (SEM)	1269:1302	The morphology and porosity of three different types of beads obtained in this work were characterized by scanning electron microscopy (SEM) and mercury intrusion porosimetry, respectively.
33805785	8	36	theme	scanning	1269:1276	arg1	SEM					1299:1301	SEM	1299:1301	SEM	1299:1301	The morphology and porosity of three different types of beads obtained in this work were characterized by scanning electron microscopy (SEM) and mercury intrusion porosimetry, respectively.
33805785	0	37	theme	Tissue	110:115	arg1	Regeneration					117:128	Bone Tissue Regeneration	105:128	Bone Tissue Regeneration	105:128	Mg,Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads Loaded with Raloxifene for Potential Use in Bone Tissue Regeneration.
33805785	9	38	theme	coupled	1449:1455	arg1	ICP-OES					1495:1501	ICP-OES	1495:1501	ICP-OES	1495:1501	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	9	38	theme	coupled	1449:1455	arg1	spectrometry					1481:1492	inductively coupled plasma optical emission spectrometry	1437:1492	inductively coupled plasma optical emission spectrometry (ICP-OES)	1437:1502	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	14	39	dep	release	2014:2020	arg1	effect					2022:2027	effect	2022:2027	no burst release effect	2005:2027	Results revealed that these beads possessed the most sustained drug release and no burst release effect.
33805785	13	40	with	beads	1791:1795	arg1	porosity					1868:1875	the lowest porosity	1857:1875	the lowest porosity	1857:1875	The beads based on chondroitin sulphate and keratin (CS/KER-RAL) with the lowest porosity resulted in the highest resistance to crushing.
33805785	9	41	theme	optical	1464:1470	arg1	ICP-OES					1495:1501	ICP-OES	1495:1501	ICP-OES	1495:1501	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	9	41	theme	optical	1464:1470	arg1	spectrometry					1481:1492	inductively coupled plasma optical emission spectrometry	1437:1492	inductively coupled plasma optical emission spectrometry (ICP-OES)	1437:1502	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	2	42	theme	ionic	420:424	arg1	modifications					426:438	ionic modifications	420:438	ionic modifications	420:438	In the treatment of bone defects, materials based on calcium phosphates (CaPs) are used due to their high resemblance to bone mineral, their non-toxicity, and their affinity to ionic modifications and increasing osteogenic properties.
33805785	0	43	theme	Si-Co-Substituted	3:19	arg1	Beads					55:59	Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads	3:59	Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads Loaded with Raloxifene for Potential Use in Bone Tissue Regeneration	3:128	Mg,Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads Loaded with Raloxifene for Potential Use in Bone Tissue Regeneration.
33805785	0	44	theme	Composite	45:53	arg1	Beads					55:59	Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads	3:59	Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads Loaded with Raloxifene for Potential Use in Bone Tissue Regeneration	3:128	Mg,Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads Loaded with Raloxifene for Potential Use in Bone Tissue Regeneration.
33805785	5	45	theme	magnesium	752:760	arg1	ions					774:777	magnesium and silicon ions	752:777	magnesium and silicon ions (Mg,Si-HA) (both of which play beneficial roles in bone formation)	752:844	HA powder, modified with magnesium and silicon ions (Mg,Si-HA) (both of which play beneficial roles in bone formation), was used to prepare composite beads.
33805785	2	46	theme	osteogenic	455:464	arg1	properties					466:475	increasing osteogenic properties	444:475	increasing osteogenic properties	444:475	In the treatment of bone defects, materials based on calcium phosphates (CaPs) are used due to their high resemblance to bone mineral, their non-toxicity, and their affinity to ionic modifications and increasing osteogenic properties.
33805785	8	47	theme	intrusion	1316:1324	arg1	porosimetry					1326:1336	mercury intrusion porosimetry	1308:1336	mercury intrusion porosimetry	1308:1336	The morphology and porosity of three different types of beads obtained in this work were characterized by scanning electron microscopy (SEM) and mercury intrusion porosimetry, respectively.
33805785	5	48	theme	silicon	766:772	arg1	ions					774:777	magnesium and silicon ions	752:777	magnesium and silicon ions (Mg,Si-HA) (both of which play beneficial roles in bone formation)	752:844	HA powder, modified with magnesium and silicon ions (Mg,Si-HA) (both of which play beneficial roles in bone formation), was used to prepare composite beads.
33805785	15	49	theme	bead	2090:2093	arg1	composition					2095:2105	the optimal bead composition	2078:2105	the optimal bead composition	2078:2105	Based on the results, it was possible to select the optimal bead composition, consisting of a mixture of chondroitin sulphate and keratin.
33805785	12	50	theme	obtained	1715:1722	arg1	beads					1724:1728	All the obtained beads	1707:1728	All the obtained beads	1707:1728	All the obtained beads revealed a spherical shape with a rough, porous surface.
33805785	10	51	theme	UV/Vis	1584:1589	arg1	spectroscopy					1591:1602	UV/Vis spectroscopy	1584:1602	UV/Vis spectroscopy	1584:1602	In vitro RAL release profiles were investigated for 12 weeks and studied using UV/Vis spectroscopy.
33805785	13	52	theme	lowest	1861:1866	arg1	porosity					1868:1875	the lowest porosity	1857:1875	the lowest porosity	1857:1875	The beads based on chondroitin sulphate and keratin (CS/KER-RAL) with the lowest porosity resulted in the highest resistance to crushing.
33805785	12	53	dep	rough	1764:1768	arg1	porous					1771:1776	porous	1771:1776	porous	1771:1776	All the obtained beads revealed a spherical shape with a rough, porous surface.
33805785	15	54	theme	chondroitin	2135:2145	arg1	sulphate					2147:2154	chondroitin sulphate	2135:2154	chondroitin sulphate	2135:2154	Based on the results, it was possible to select the optimal bead composition, consisting of a mixture of chondroitin sulphate and keratin.
33805785	7	55	theme	Mg	1062:1063	arg1	ions					1065:1068	Mg ions	1062:1068	Mg ions	1062:1068	Cross-linking of beads containing raloxifene hydrochloride (RAL) was carried out with Mg ions in order to additionally increase the concentration of this element on the material surface.
33805785	4	56	theme	work	616:619	arg1	aim					604:606	the aim	600:606	the aim of this work	600:619	Therefore, the aim of this work was to fabricate hydroxyapatite-based composite beads for potential use as local carriers for raloxifene.
33805785	7	57	theme	raloxifene	1010:1019	arg1	RAL					1036:1038	RAL	1036:1038	RAL	1036:1038	Cross-linking of beads containing raloxifene hydrochloride (RAL) was carried out with Mg ions in order to additionally increase the concentration of this element on the material surface.
33805785	7	57	theme	raloxifene	1010:1019	arg1	hydrochloride					1021:1033	raloxifene hydrochloride	1010:1033	raloxifene hydrochloride (RAL)	1010:1039	Cross-linking of beads containing raloxifene hydrochloride (RAL) was carried out with Mg ions in order to additionally increase the concentration of this element on the material surface.
33805785	1	58	theme	bone	203:206	arg1	fragility					208:216	bone fragility	203:216	bone fragility	203:216	Osteoporosis is a worldwide chronic disease characterized by increasing bone fragility and fracture likelihood.
33805785	6	59	theme	organic	890:896	arg1	matrix					898:903	an organic matrix	887:903	an organic matrix	887:903	As an organic matrix, sodium alginate with chondroitin sulphate and/or keratin was applied.
33805785	6	59	theme	organic	890:896	arg1	alginate					913:920	sodium alginate	906:920	sodium alginate with chondroitin sulphate and/or keratin	906:961	As an organic matrix, sodium alginate with chondroitin sulphate and/or keratin was applied.
33805785	7	60	theme	beads	993:997	arg1	Cross-linking					976:988	Cross-linking	976:988	Cross-linking of beads containing raloxifene hydrochloride (RAL)	976:1039	Cross-linking of beads containing raloxifene hydrochloride (RAL) was carried out with Mg ions in order to additionally increase the concentration of this element on the material surface.
33805785	8	61	theme	mercury	1308:1314	arg1	porosimetry					1326:1336	mercury intrusion porosimetry	1308:1336	mercury intrusion porosimetry	1308:1336	The morphology and porosity of three different types of beads obtained in this work were characterized by scanning electron microscopy (SEM) and mercury intrusion porosimetry, respectively.
33805785	11	62	from	tests	1658:1662	arg1	lines					1700:1704	osteosarcoma cell lines	1682:1704	osteosarcoma cell lines	1682:1704	The beads were also subjected to in vitro biological tests on osteoblast and osteosarcoma cell lines.
33805785	11	62	from	tests	1658:1662	arg1	osteoblast					1667:1676	osteoblast	1667:1676	osteoblast	1667:1676	The beads were also subjected to in vitro biological tests on osteoblast and osteosarcoma cell lines.
33805785	0	63	from	Use	98:100	arg1	Regeneration					117:128	Bone Tissue Regeneration	105:128	Bone Tissue Regeneration	105:128	Mg,Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads Loaded with Raloxifene for Potential Use in Bone Tissue Regeneration.
33805785	10	64	theme	release	1518:1524	arg1	profiles					1526:1533	In vitro RAL release profiles	1505:1533	In vitro RAL release profiles	1505:1533	In vitro RAL release profiles were investigated for 12 weeks and studied using UV/Vis spectroscopy.
33805785	11	65	theme	osteosarcoma	1682:1693	arg1	lines					1700:1704	osteosarcoma cell lines	1682:1704	osteosarcoma cell lines	1682:1704	The beads were also subjected to in vitro biological tests on osteoblast and osteosarcoma cell lines.
33805785	3	66	theme	local	568:572	arg1	delivery					579:586	local drug delivery	568:586	local drug delivery	568:586	Moreover, CaPs, especially hydroxyapatite (HA), can be successfully used as a vehicle for local drug delivery.
33805785	8	67	theme	different	1200:1208	arg1	types					1210:1214	three different types	1194:1214	three different types of beads obtained in this work	1194:1245	The morphology and porosity of three different types of beads obtained in this work were characterized by scanning electron microscopy (SEM) and mercury intrusion porosimetry, respectively.
33805785	5	68	used	used	851:854	arg2	powder					730:735	HA powder	727:735	HA powder	727:735	HA powder, modified with magnesium and silicon ions (Mg,Si-HA) (both of which play beneficial roles in bone formation), was used to prepare composite beads.
33805785	5	69	theme	HA	727:728	arg1	powder					730:735	HA powder	727:735	HA powder	727:735	HA powder, modified with magnesium and silicon ions (Mg,Si-HA) (both of which play beneficial roles in bone formation), was used to prepare composite beads.
33805785	2	70	theme	defects	268:274	arg1	treatment					250:258	the treatment	246:258	the treatment of bone defects	246:274	In the treatment of bone defects, materials based on calcium phosphates (CaPs) are used due to their high resemblance to bone mineral, their non-toxicity, and their affinity to ionic modifications and increasing osteogenic properties.
33805785	1	71	theme	worldwide	149:157	arg1	disease					167:173	a worldwide chronic disease	147:173	a worldwide chronic disease characterized by increasing bone fragility and fracture likelihood	147:240	Osteoporosis is a worldwide chronic disease characterized by increasing bone fragility and fracture likelihood.
33805785	1	71	theme	worldwide	149:157	arg1	Osteoporosis					131:142	Osteoporosis	131:142	Osteoporosis	131:142	Osteoporosis is a worldwide chronic disease characterized by increasing bone fragility and fracture likelihood.
33805785	6	72	theme	chondroitin	927:937	arg1	sulphate					939:946	chondroitin sulphate	927:946	chondroitin sulphate	927:946	As an organic matrix, sodium alginate with chondroitin sulphate and/or keratin was applied.
33805785	4	73	theme	hydroxyapatite-based	638:657	arg1	beads					669:673	hydroxyapatite-based composite beads	638:673	hydroxyapatite-based composite beads	638:673	Therefore, the aim of this work was to fabricate hydroxyapatite-based composite beads for potential use as local carriers for raloxifene.
33805785	7	74	theme	element	1130:1136	arg1	concentration					1108:1120	the concentration	1104:1120	the concentration of this element on the material surface	1104:1160	Cross-linking of beads containing raloxifene hydrochloride (RAL) was carried out with Mg ions in order to additionally increase the concentration of this element on the material surface.
33805785	5	75	theme	bone	830:833	arg1	formation					835:843	bone formation	830:843	bone formation	830:843	HA powder, modified with magnesium and silicon ions (Mg,Si-HA) (both of which play beneficial roles in bone formation), was used to prepare composite beads.
33805785	0	76	theme	Bone	105:108	arg1	Regeneration					117:128	Bone Tissue Regeneration	105:128	Bone Tissue Regeneration	105:128	Mg,Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads Loaded with Raloxifene for Potential Use in Bone Tissue Regeneration.
33805785	14	77	theme	drug	1988:1991	arg1	release					1993:1999	the most sustained drug release	1969:1999	the most sustained drug release	1969:1999	Results revealed that these beads possessed the most sustained drug release and no burst release effect.
33805785	9	78	attach	released	1367:1374	arg1	powder					1394:1399	the Mg,Si-HA powder	1381:1399	powder	1394:1399	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	9	78	attach	released	1367:1374	arg1	beads					1414:1418	the beads	1410:1418	the beads	1410:1418	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	9	78	attach	released	1367:1374	arg2	Mg					1357:1358	Mg	1357:1358	Mg	1357:1358	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	14	79	contain	possessed	1959:1967	arg2	release					1993:1999	the most sustained drug release	1969:1999	the most sustained drug release	1969:1999	Results revealed that these beads possessed the most sustained drug release and no burst release effect.
33805785	14	79	contain	possessed	1959:1967	arg2	release					2014:2020	no burst release	2005:2020	no burst release effect	2005:2027	Results revealed that these beads possessed the most sustained drug release and no burst release effect.
33805785	14	79	contain	possessed	1959:1967	arg1	beads					1953:1957	these beads	1947:1957	these beads	1947:1957	Results revealed that these beads possessed the most sustained drug release and no burst release effect.
33805785	9	80	theme	plasma	1457:1462	arg1	ICP-OES					1495:1501	ICP-OES	1495:1501	ICP-OES	1495:1501	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	9	80	theme	plasma	1457:1462	arg1	spectrometry					1481:1492	inductively coupled plasma optical emission spectrometry	1437:1492	inductively coupled plasma optical emission spectrometry (ICP-OES)	1437:1502	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	8	81	theme	electron	1278:1285	arg1	microscopy					1287:1296	scanning electron microscopy	1269:1296	scanning electron microscopy (SEM)	1269:1302	The morphology and porosity of three different types of beads obtained in this work were characterized by scanning electron microscopy (SEM) and mercury intrusion porosimetry, respectively.
33805785	8	81	theme	electron	1278:1285	arg1	SEM					1299:1301	SEM	1299:1301	SEM	1299:1301	The morphology and porosity of three different types of beads obtained in this work were characterized by scanning electron microscopy (SEM) and mercury intrusion porosimetry, respectively.
33805785	2	82	theme	mineral	369:375	arg1	bone					364:367	bone mineral	364:375	bone mineral	364:375	In the treatment of bone defects, materials based on calcium phosphates (CaPs) are used due to their high resemblance to bone mineral, their non-toxicity, and their affinity to ionic modifications and increasing osteogenic properties.
33805785	0	83	theme	Hydroxyapatite/Alginate	21:43	arg1	Beads					55:59	Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads	3:59	Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads Loaded with Raloxifene for Potential Use in Bone Tissue Regeneration	3:128	Mg,Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads Loaded with Raloxifene for Potential Use in Bone Tissue Regeneration.
33805785	5	84	theme	composite	867:875	arg1	beads					877:881	composite beads	867:881	composite beads	867:881	HA powder, modified with magnesium and silicon ions (Mg,Si-HA) (both of which play beneficial roles in bone formation), was used to prepare composite beads.
33805785	7	85	contain	containing	999:1008	arg2	RAL					1036:1038	RAL	1036:1038	RAL	1036:1038	Cross-linking of beads containing raloxifene hydrochloride (RAL) was carried out with Mg ions in order to additionally increase the concentration of this element on the material surface.
33805785	7	85	contain	containing	999:1008	arg1	beads					993:997	beads	993:997	beads containing raloxifene hydrochloride (RAL)	993:1039	Cross-linking of beads containing raloxifene hydrochloride (RAL) was carried out with Mg ions in order to additionally increase the concentration of this element on the material surface.
33805785	7	85	contain	containing	999:1008	arg2	hydrochloride					1021:1033	raloxifene hydrochloride	1010:1033	raloxifene hydrochloride (RAL)	1010:1039	Cross-linking of beads containing raloxifene hydrochloride (RAL) was carried out with Mg ions in order to additionally increase the concentration of this element on the material surface.
33805785	12	86	theme	rough	1764:1768	arg1	surface					1778:1784	a rough, porous surface	1762:1784	a rough, porous surface	1762:1784	All the obtained beads revealed a spherical shape with a rough, porous surface.
33805785	0	87	dep	Beads	55:59	arg1	Mg					0:1	Mg	0:1	Mg	0:1	Mg,Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads Loaded with Raloxifene for Potential Use in Bone Tissue Regeneration.
33805785	2	88	theme	increasing	444:453	arg1	properties					466:475	increasing osteogenic properties	444:475	increasing osteogenic properties	444:475	In the treatment of bone defects, materials based on calcium phosphates (CaPs) are used due to their high resemblance to bone mineral, their non-toxicity, and their affinity to ionic modifications and increasing osteogenic properties.
33805785	9	89	dep	Mg	1357:1358	arg1	The					1353:1355	The	1353:1355	The	1353:1355	The Mg and Si released from the Mg,Si-HA powder and from the beads were measured by inductively coupled plasma optical emission spectrometry (ICP-OES).
33805785	13	90	theme	highest	1893:1899	arg1	resistance					1901:1910	the highest resistance	1889:1910	the highest resistance to crushing	1889:1922	The beads based on chondroitin sulphate and keratin (CS/KER-RAL) with the lowest porosity resulted in the highest resistance to crushing.
33805785	12	91	theme	spherical	1741:1749	arg1	shape					1751:1755	a spherical shape	1739:1755	a spherical shape with a rough, porous surface	1739:1784	All the obtained beads revealed a spherical shape with a rough, porous surface.
33805785	2	92	used	used	326:329	arg2	materials					277:285	materials	277:285	materials based on calcium phosphates (CaPs)	277:320	In the treatment of bone defects, materials based on calcium phosphates (CaPs) are used due to their high resemblance to bone mineral, their non-toxicity, and their affinity to ionic modifications and increasing osteogenic properties.
33805785	12	93	with	shape	1751:1755	arg1	surface					1778:1784	a rough, porous surface	1762:1784	a rough, porous surface	1762:1784	All the obtained beads revealed a spherical shape with a rough, porous surface.
32017022	2	0	theme	regioselective	480:493	arg1	β-1,3-glycosylation					495:513	the regioselective β-1,3-glycosylation	476:513	the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor	476:565	Here, we develop a flow process for the glycosynthase reaction, which is the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor.
32017022	2	0	theme	regioselective	480:493	arg1	process					427:433	a flow process	420:433	a flow process	420:433	Here, we develop a flow process for the glycosynthase reaction, which is the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor.
32017022	3	1	theme	II	708:709	arg1	production					690:699	stable continuous production	672:699	stable continuous production of LNT II (145-200 mM)	672:722	Using the glycosynthase immobilized on agarose beads (∼30 mg/g) packed into a fixed bed (1 ml), we show stable continuous production of LNT II (145-200 mM) at quantitative yield from the donor substrate.
32017022	6	2	theme	chemistry	1337:1345	arg1	principles					1347:1356	flow chemistry principles	1332:1356	flow chemistry principles	1332:1356	Our study thus provides a strong case for the application of flow chemistry principles to glycosynthase reactions and by that, it reveals the important synergy between enzyme and reaction engineering for biocatalytic synthesis of oligosaccharides.
32017022	5	3	theme	donor	1182:1186	arg1	substrate					1188:1196	donor substrate	1182:1196	donor substrate	1182:1196	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	6	4	theme	principles	1347:1356	arg1	application					1317:1327	the application	1313:1327	the application of flow chemistry principles to glycosynthase reactions	1313:1383	Our study thus provides a strong case for the application of flow chemistry principles to glycosynthase reactions and by that, it reveals the important synergy between enzyme and reaction engineering for biocatalytic synthesis of oligosaccharides.
32017022	1	5	theme	core	350:353	arg1	lacto-N-triose					320:333	lacto-N-triose II	320:336	lacto-N-triose II (LNT II)	320:345	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	1	5	theme	core	350:353	arg1	unit					366:369	a core structural unit	348:369	a core structural unit of human milk oligosaccharides	348:400	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	1	6	theme	Bifidobacterium	163:177	arg1	β-N-acetyl-hexosaminidase					187:211	Bifidobacterium bifidum β-N-acetyl-hexosaminidase	163:211	Bifidobacterium bifidum β-N-acetyl-hexosaminidase	163:211	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	5	7	theme	substrate	1188:1196	arg1	decomposition					1165:1177	decomposition	1165:1177	decomposition of donor substrate	1165:1196	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	5	7	theme	substrate	1188:1196	arg1	hydrolysis					1209:1218	enzymatic hydrolysis	1199:1218	enzymatic hydrolysis of LNT II	1199:1228	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	2	8	theme	d-glucosamine	533:545	arg1	donor					561:565	a d-glucosamine 1,2-oxazoline donor	531:565	a d-glucosamine 1,2-oxazoline donor	531:565	Here, we develop a flow process for the glycosynthase reaction, which is the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor.
32017022	1	9	theme	structural	355:364	arg1	lacto-N-triose					320:333	lacto-N-triose II	320:336	lacto-N-triose II (LNT II)	320:345	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	1	9	theme	structural	355:364	arg1	unit					366:369	a core structural unit	348:369	a core structural unit of human milk oligosaccharides	348:400	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	4	10	theme	comparable	831:840	arg1	conditions					842:851	exactly comparable conditions	823:851	exactly comparable conditions	823:851	The wild-type β-N-acetyl-hexosaminidase used under exactly comparable conditions gives primarily (∼85%) the hydrolysis product d-glucosamine.
32017022	5	11	theme	optimum	1241:1247	arg1	efficiency					1259:1268	optimum synthetic efficiency	1241:1268	optimum synthetic efficiency	1241:1268	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	0	12	theme	engineered	84:93	arg1	β-hexosaminidase					95:110	engineered β-hexosaminidase	84:110	engineered β-hexosaminidase immobilized on solid support	84:139	Glycosynthase reaction meets the flow: Continuous synthesis of lacto-N-triose II by engineered β-hexosaminidase immobilized on solid support.
32017022	3	13	theme	stable	672:677	arg1	production					690:699	stable continuous production	672:699	stable continuous production of LNT II (145-200 mM)	672:722	Using the glycosynthase immobilized on agarose beads (∼30 mg/g) packed into a fixed bed (1 ml), we show stable continuous production of LNT II (145-200 mM) at quantitative yield from the donor substrate.
32017022	3	14	from	substrate	761:769	arg1	yield					740:744	quantitative yield	727:744	quantitative yield from the donor substrate	727:769	Using the glycosynthase immobilized on agarose beads (∼30 mg/g) packed into a fixed bed (1 ml), we show stable continuous production of LNT II (145-200 mM) at quantitative yield from the donor substrate.
32017022	5	15	theme	enzymatic	1199:1207	arg1	decomposition					1165:1177	decomposition	1165:1177	decomposition of donor substrate	1165:1196	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	5	15	theme	enzymatic	1199:1207	arg1	hydrolysis					1209:1218	enzymatic hydrolysis	1199:1218	enzymatic hydrolysis of LNT II	1199:1228	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	1	16	theme	bifidum	179:185	arg1	β-N-acetyl-hexosaminidase					187:211	Bifidobacterium bifidum β-N-acetyl-hexosaminidase	163:211	Bifidobacterium bifidum β-N-acetyl-hexosaminidase	163:211	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	2	17	theme	lactose	518:524	arg1	β-1,3-glycosylation					495:513	the regioselective β-1,3-glycosylation	476:513	the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor	476:565	Here, we develop a flow process for the glycosynthase reaction, which is the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor.
32017022	2	17	theme	lactose	518:524	arg1	process					427:433	a flow process	420:433	a flow process	420:433	Here, we develop a flow process for the glycosynthase reaction, which is the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor.
32017022	1	18	theme	human	374:378	arg1	oligosaccharides					385:400	human milk oligosaccharides	374:400	human milk oligosaccharides	374:400	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	4	19	dep	primarily	859:867	arg1	%					873:873	∼85%	870:873	∼85%	870:873	The wild-type β-N-acetyl-hexosaminidase used under exactly comparable conditions gives primarily (∼85%) the hydrolysis product d-glucosamine.
32017022	1	20	theme	β-N-acetyl-hexosaminidase	187:211	arg1	variant					152:158	The D746E variant	142:158	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase	142:211	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	1	20	theme	β-N-acetyl-hexosaminidase	187:211	arg1	glycosynthase					228:240	a promising glycosynthase	216:240	a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides	216:400	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	2	21	theme	glycosynthase	443:455	arg1	reaction					457:464	the glycosynthase reaction	439:464	the glycosynthase reaction	439:464	Here, we develop a flow process for the glycosynthase reaction, which is the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor.
32017022	1	22	theme	milk	380:383	arg1	oligosaccharides					385:400	human milk oligosaccharides	374:400	human milk oligosaccharides	374:400	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	5	23	from	reactions	1154:1162	arg1	uncoupling					1081:1090	an effective uncoupling	1068:1090	an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II)	1068:1229	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	2	24	gly	β-1,3-glycosylation	495:513	arg1	lactose					518:524	lactose	518:524	lactose	518:524	Here, we develop a flow process for the glycosynthase reaction, which is the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor.
32017022	5	25	theme	side	1149:1152	arg1	reactions					1154:1162	the slower side reactions	1138:1162	the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II)	1138:1229	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	3	26	theme	continuous	679:688	arg1	production					690:699	stable continuous production	672:699	stable continuous production of LNT II (145-200 mM)	672:722	Using the glycosynthase immobilized on agarose beads (∼30 mg/g) packed into a fixed bed (1 ml), we show stable continuous production of LNT II (145-200 mM) at quantitative yield from the donor substrate.
32017022	0	27	theme	Glycosynthase	0:12	arg1	reaction					14:21	Glycosynthase reaction	0:21	Glycosynthase reaction	0:21	Glycosynthase reaction meets the flow: Continuous synthesis of lacto-N-triose II by engineered β-hexosaminidase immobilized on solid support.
32017022	3	28	theme	quantitative	727:738	arg1	yield					740:744	quantitative yield	727:744	quantitative yield from the donor substrate	727:769	Using the glycosynthase immobilized on agarose beads (∼30 mg/g) packed into a fixed bed (1 ml), we show stable continuous production of LNT II (145-200 mM) at quantitative yield from the donor substrate.
32017022	6	29	theme	oligosaccharides	1501:1516	arg1	synthesis					1488:1496	biocatalytic synthesis	1475:1496	biocatalytic synthesis of oligosaccharides	1475:1516	Our study thus provides a strong case for the application of flow chemistry principles to glycosynthase reactions and by that, it reveals the important synergy between enzyme and reaction engineering for biocatalytic synthesis of oligosaccharides.
32017022	1	30	theme	promising	218:226	arg1	glycosynthase					228:240	a promising glycosynthase	216:240	a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides	216:400	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	1	30	theme	promising	218:226	arg1	variant					152:158	The D746E variant	142:158	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase	142:211	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	1	31	theme	lacto-N-triose	320:333	arg1	synthesis					307:315	the synthesis	303:315	the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides	303:400	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	0	32	theme	solid	127:131	arg1	support					133:139	solid support	127:139	solid support	127:139	Glycosynthase reaction meets the flow: Continuous synthesis of lacto-N-triose II by engineered β-hexosaminidase immobilized on solid support.
32017022	1	33	theme	oligosaccharides	385:400	arg1	lacto-N-triose					320:333	lacto-N-triose II	320:336	lacto-N-triose II (LNT II)	320:345	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	1	33	theme	oligosaccharides	385:400	arg1	unit					366:369	a core structural unit	348:369	a core structural unit of human milk oligosaccharides	348:400	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	5	34	theme	LNT	1099:1101	arg1	∼80-100 mM/min					1117:1130	∼80-100 mM/min	1117:1130	∼80-100 mM/min	1117:1130	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	5	34	theme	LNT	1099:1101	arg1	formation					1106:1114	the LNT II formation	1095:1114	the LNT II formation (∼80-100 mM/min)	1095:1131	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	5	35	theme	II	1227:1228	arg1	decomposition					1165:1177	decomposition	1165:1177	decomposition of donor substrate	1165:1196	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	5	35	theme	II	1227:1228	arg1	hydrolysis					1209:1218	enzymatic hydrolysis	1199:1218	enzymatic hydrolysis of LNT II	1199:1228	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	5	36	theme	reactor	1003:1009	arg1	types					994:998	mixed-vessel types	981:998	mixed-vessel types of reactor	981:1009	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	1	37	from	activity	289:296	arg1	deficient					266:274	deficient	266:274	deficient	266:274	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	6	38	theme	strong	1297:1302	arg1	case					1304:1307	a strong case	1295:1307	a strong case for the application of flow chemistry principles to glycosynthase reactions and by that	1295:1395	Our study thus provides a strong case for the application of flow chemistry principles to glycosynthase reactions and by that, it reveals the important synergy between enzyme and reaction engineering for biocatalytic synthesis of oligosaccharides.
32017022	6	39	theme	biocatalytic	1475:1486	arg1	synthesis					1488:1496	biocatalytic synthesis	1475:1496	biocatalytic synthesis of oligosaccharides	1475:1516	Our study thus provides a strong case for the application of flow chemistry principles to glycosynthase reactions and by that, it reveals the important synergy between enzyme and reaction engineering for biocatalytic synthesis of oligosaccharides.
32017022	3	40	theme	donor	755:759	arg1	substrate					761:769	the donor substrate	751:769	the donor substrate	751:769	Using the glycosynthase immobilized on agarose beads (∼30 mg/g) packed into a fixed bed (1 ml), we show stable continuous production of LNT II (145-200 mM) at quantitative yield from the donor substrate.
32017022	2	41	theme	1,2-oxazoline	547:559	arg1	donor					561:565	a d-glucosamine 1,2-oxazoline donor	531:565	a d-glucosamine 1,2-oxazoline donor	531:565	Here, we develop a flow process for the glycosynthase reaction, which is the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor.
32017022	3	42	theme	fixed	646:650	arg1	1 ml					657:660	1 ml	657:660	1 ml	657:660	Using the glycosynthase immobilized on agarose beads (∼30 mg/g) packed into a fixed bed (1 ml), we show stable continuous production of LNT II (145-200 mM) at quantitative yield from the donor substrate.
32017022	3	42	theme	fixed	646:650	arg1	bed					652:654	a fixed bed	644:654	a fixed bed (1 ml)	644:661	Using the glycosynthase immobilized on agarose beads (∼30 mg/g) packed into a fixed bed (1 ml), we show stable continuous production of LNT II (145-200 mM) at quantitative yield from the donor substrate.
32017022	1	43	theme	engineered	243:252	arg1	glycosidase					254:264	engineered glycosidase	243:264	engineered glycosidase deficient in hydrolase activity	243:296	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	1	44	theme	LNT	339:341	arg1	lacto-N-triose					320:333	lacto-N-triose II	320:336	lacto-N-triose II (LNT II)	320:345	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	1	44	theme	LNT	339:341	arg1	II					343:344	LNT II	339:344	LNT II	339:344	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	4	45	theme	product	891:897	arg1	d-glucosamine					899:911	the hydrolysis product d-glucosamine	876:911	the hydrolysis product d-glucosamine	876:911	The wild-type β-N-acetyl-hexosaminidase used under exactly comparable conditions gives primarily (∼85%) the hydrolysis product d-glucosamine.
32017022	3	46	theme	agarose	607:613	arg1	∼30 mg/g					622:629	∼30 mg/g	622:629	∼30 mg/g	622:629	Using the glycosynthase immobilized on agarose beads (∼30 mg/g) packed into a fixed bed (1 ml), we show stable continuous production of LNT II (145-200 mM) at quantitative yield from the donor substrate.
32017022	3	46	theme	agarose	607:613	arg1	beads					615:619	agarose beads	607:619	agarose beads (∼30 mg/g) packed into a fixed bed (1 ml)	607:661	Using the glycosynthase immobilized on agarose beads (∼30 mg/g) packed into a fixed bed (1 ml), we show stable continuous production of LNT II (145-200 mM) at quantitative yield from the donor substrate.
32017022	3	47	theme	LNT	704:706	arg1	II					708:709	LNT II	704:709	LNT II (145-200 mM)	704:722	Using the glycosynthase immobilized on agarose beads (∼30 mg/g) packed into a fixed bed (1 ml), we show stable continuous production of LNT II (145-200 mM) at quantitative yield from the donor substrate.
32017022	3	47	theme	LNT	704:706	arg1	145-200 mM					712:721	145-200 mM	712:721	145-200 mM	712:721	Using the glycosynthase immobilized on agarose beads (∼30 mg/g) packed into a fixed bed (1 ml), we show stable continuous production of LNT II (145-200 mM) at quantitative yield from the donor substrate.
32017022	5	48	dep	reactions	1154:1162	arg1	decomposition					1165:1177	decomposition	1165:1177	decomposition of donor substrate	1165:1196	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	5	48	dep	reactions	1154:1162	arg1	hydrolysis					1209:1218	enzymatic hydrolysis	1199:1218	enzymatic hydrolysis of LNT II	1199:1228	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	0	49	theme	Continuous	39:48	arg1	synthesis					50:58	Continuous synthesis	39:58	Continuous synthesis of lacto-N-triose II by engineered β-hexosaminidase immobilized on solid support	39:139	Glycosynthase reaction meets the flow: Continuous synthesis of lacto-N-triose II by engineered β-hexosaminidase immobilized on solid support.
32017022	5	50	theme	slower	1142:1147	arg1	reactions					1154:1162	the slower side reactions	1138:1162	the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II)	1138:1229	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	4	51	theme	hydrolysis	880:889	arg1	d-glucosamine					899:911	the hydrolysis product d-glucosamine	876:911	the hydrolysis product d-glucosamine	876:911	The wild-type β-N-acetyl-hexosaminidase used under exactly comparable conditions gives primarily (∼85%) the hydrolysis product d-glucosamine.
32017022	5	52	theme	glycosynthase	1029:1041	arg1	reactor					1048:1054	the glycosynthase flow reactor	1025:1054	the glycosynthase flow reactor	1025:1054	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	5	53	theme	effective	1071:1079	arg1	uncoupling					1081:1090	an effective uncoupling	1068:1090	an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II)	1068:1229	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	5	54	theme	synthetic	1249:1257	arg1	efficiency					1259:1268	optimum synthetic efficiency	1241:1268	optimum synthetic efficiency	1241:1268	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	4	55	theme	wild-type	776:784	arg1	β-N-acetyl-hexosaminidase					786:810	The wild-type β-N-acetyl-hexosaminidase	772:810	The wild-type β-N-acetyl-hexosaminidase used under exactly comparable conditions	772:851	The wild-type β-N-acetyl-hexosaminidase used under exactly comparable conditions gives primarily (∼85%) the hydrolysis product d-glucosamine.
32017022	5	56	theme	flow	1043:1046	arg1	reactor					1048:1054	the glycosynthase flow reactor	1025:1054	the glycosynthase flow reactor	1025:1054	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	5	57	theme	mixed-vessel	981:992	arg1	types					994:998	mixed-vessel types	981:998	mixed-vessel types of reactor	981:1009	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	5	58	theme	short	926:930	arg1	2 min					949:953	2 min	949:953	2 min	949:953	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	5	58	theme	short	926:930	arg1	times					942:946	short residence times	926:946	short residence times (2 min) that are challenging for mixed-vessel types of reactor	926:1009	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	2	59	from	donor	561:565	arg1	β-1,3-glycosylation					495:513	the regioselective β-1,3-glycosylation	476:513	the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor	476:565	Here, we develop a flow process for the glycosynthase reaction, which is the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor.
32017022	2	59	from	donor	561:565	arg1	process					427:433	a flow process	420:433	a flow process	420:433	Here, we develop a flow process for the glycosynthase reaction, which is the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor.
32017022	1	60	from	deficient	266:274	arg1	activity					289:296	hydrolase activity	279:296	hydrolase activity	279:296	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	0	61	dep	meets	23:27	arg1	synthesis					50:58	Continuous synthesis	39:58	Continuous synthesis of lacto-N-triose II by engineered β-hexosaminidase immobilized on solid support	39:139	Glycosynthase reaction meets the flow: Continuous synthesis of lacto-N-triose II by engineered β-hexosaminidase immobilized on solid support.
32017022	5	62	theme	residence	932:940	arg1	2 min					949:953	2 min	949:953	2 min	949:953	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	5	62	theme	residence	932:940	arg1	times					942:946	short residence times	926:946	short residence times (2 min) that are challenging for mixed-vessel types of reactor	926:1009	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	6	63	theme	flow	1332:1335	arg1	principles					1347:1356	flow chemistry principles	1332:1356	flow chemistry principles	1332:1356	Our study thus provides a strong case for the application of flow chemistry principles to glycosynthase reactions and by that, it reveals the important synergy between enzyme and reaction engineering for biocatalytic synthesis of oligosaccharides.
32017022	1	64	theme	deficient	266:274	arg1	glycosidase					254:264	engineered glycosidase	243:264	engineered glycosidase deficient in hydrolase activity	243:296	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	0	65	theme	lacto-N-triose	63:76	arg1	synthesis					50:58	Continuous synthesis	39:58	Continuous synthesis of lacto-N-triose II by engineered β-hexosaminidase immobilized on solid support	39:139	Glycosynthase reaction meets the flow: Continuous synthesis of lacto-N-triose II by engineered β-hexosaminidase immobilized on solid support.
32017022	2	66	theme	flow	422:425	arg1	β-1,3-glycosylation					495:513	the regioselective β-1,3-glycosylation	476:513	the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor	476:565	Here, we develop a flow process for the glycosynthase reaction, which is the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor.
32017022	2	66	theme	flow	422:425	arg1	process					427:433	a flow process	420:433	a flow process	420:433	Here, we develop a flow process for the glycosynthase reaction, which is the regioselective β-1,3-glycosylation of lactose from a d-glucosamine 1,2-oxazoline donor.
32017022	1	67	theme	D746E	146:150	arg1	variant					152:158	The D746E variant	142:158	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase	142:211	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	1	67	theme	D746E	146:150	arg1	glycosynthase					228:240	a promising glycosynthase	216:240	a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides	216:400	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	6	68	theme	reaction	1450:1457	arg1	engineering					1459:1469	reaction engineering	1450:1469	reaction engineering	1450:1469	Our study thus provides a strong case for the application of flow chemistry principles to glycosynthase reactions and by that, it reveals the important synergy between enzyme and reaction engineering for biocatalytic synthesis of oligosaccharides.
32017022	5	69	theme	LNT	1223:1225	arg1	II					1227:1228	LNT II	1223:1228	LNT II	1223:1228	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	6	70	theme	glycosynthase	1361:1373	arg1	reactions					1375:1383	glycosynthase reactions	1361:1383	glycosynthase reactions	1361:1383	Our study thus provides a strong case for the application of flow chemistry principles to glycosynthase reactions and by that, it reveals the important synergy between enzyme and reaction engineering for biocatalytic synthesis of oligosaccharides.
32017022	5	71	theme	formation	1106:1114	arg1	uncoupling					1081:1090	an effective uncoupling	1068:1090	an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II)	1068:1229	By enabling short residence times (2 min) that are challenging for mixed-vessel types of reactor to establish, the glycosynthase flow reactor succeeds in an effective uncoupling of the LNT II formation (∼80-100 mM/min) from the slower side reactions (decomposition of donor substrate, enzymatic hydrolysis of LNT II) to obtain optimum synthetic efficiency.
32017022	1	72	dep	glycosynthase	228:240	arg1	glycosidase					254:264	engineered glycosidase	243:264	engineered glycosidase deficient in hydrolase activity	243:296	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32017022	6	73	theme	important	1413:1421	arg1	synergy					1423:1429	the important synergy	1409:1429	the important synergy between enzyme and reaction engineering for biocatalytic synthesis of oligosaccharides	1409:1516	Our study thus provides a strong case for the application of flow chemistry principles to glycosynthase reactions and by that, it reveals the important synergy between enzyme and reaction engineering for biocatalytic synthesis of oligosaccharides.
32017022	1	74	theme	hydrolase	279:287	arg1	activity					289:296	hydrolase activity	279:296	hydrolase activity	279:296	The D746E variant of Bifidobacterium bifidum β-N-acetyl-hexosaminidase is a promising glycosynthase (engineered glycosidase deficient in hydrolase activity) for the synthesis of lacto-N-triose II (LNT II), a core structural unit of human milk oligosaccharides.
32248537	0	0	theme	cooked	75:80	arg1	tubers					89:94	cooked potato tubers	75:94	cooked potato tubers	75:94	Agronomical traits, phenolic compounds and antioxidant activity in raw and cooked potato tubers growing under saline conditions.
32248537	10	1	theme	coumaric	1444:1451	arg1	acid					1453:1456	coumaric acid	1444:1456	coumaric acid	1444:1456	However, coumaric acid increased in Alaska tubers.
32248537	11	2	theme	yield	1576:1580	arg1	determinants					1554:1565	important determinants	1544:1565	important determinants of tuber yield and composition	1544:1596	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	2	theme	yield	1576:1580	arg1	level					1506:1510	CONCLUSION Salinity level	1486:1510	CONCLUSION Salinity level	1486:1510	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	2	theme	yield	1576:1580	arg1	variety					1513:1519	variety	1513:1519	variety	1513:1519	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	2	theme	yield	1576:1580	arg1	method					1533:1538	cooking method	1525:1538	cooking method	1525:1538	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	3	3	dep	levels	481:486	arg1	T1					489:490	T1	489:490	T1	489:490	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	9	4	theme	phenolic	1297:1304	arg1	compounds					1306:1314	Individual phenolic compounds	1286:1314	Individual phenolic compounds	1286:1314	Individual phenolic compounds exhibited different response to cooking as quercetin, caffeic acid and catechin decreased significantly after boiling.
32248537	5	5	theme	antioxidant	866:876	arg1	RAC					888:890	RAC	888:890	RAC	888:890	Carotenoids, total and individual phenolics determined by high-performance liquid chromatography (HPLC), relative antioxidant capacity (RAC) and ions content were analyzed, in both raw and water boiled tubers.
32248537	5	5	theme	antioxidant	866:876	arg1	capacity					878:885	relative antioxidant capacity	857:885	relative antioxidant capacity (RAC)	857:891	Carotenoids, total and individual phenolics determined by high-performance liquid chromatography (HPLC), relative antioxidant capacity (RAC) and ions content were analyzed, in both raw and water boiled tubers.
32248537	0	6	from	traits	12:17	arg1	raw					67:69	raw	67:69	raw	67:69	Agronomical traits, phenolic compounds and antioxidant activity in raw and cooked potato tubers growing under saline conditions.
32248537	5	7	theme	water	941:945	arg1	tubers					954:959	both raw and water boiled tubers	928:959	tubers	954:959	Carotenoids, total and individual phenolics determined by high-performance liquid chromatography (HPLC), relative antioxidant capacity (RAC) and ions content were analyzed, in both raw and water boiled tubers.
32248537	1	8	theme	tuber	158:162	arg1	compositions					164:175	tuber compositions	158:175	tuber compositions	158:175	BACKGROUND Potato yields and tuber compositions are linked to mechanisms adopted by plants to cope with salinity and often can change after cooking.
32248537	3	9	theme	ms cm-1	621:627	arg1	EC					629:630	8.5 ms cm-1 EC	617:630	T3: 8.5 ms cm-1 EC	613:630	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	3	10	theme	salt	476:479	arg1	levels					481:486	distinct salt levels	467:486	distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC)	467:631	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	6	11	theme	salinity	1062:1069	arg1	level					1071:1075	the salinity level	1058:1075	the salinity level	1058:1075	RESULTS Tuber yield, starch, dry matter, ions and antioxidants were significantly influenced by the salinity level and variety.
32248537	2	12	theme	current	282:288	arg1	study					290:294	The current study	278:294	The current study	278:294	The current study aimed to evaluate the effects of salinity, variety and cooking method in the composition of potato tubers.
32248537	3	13	dep	T3	613:614	arg1	EC					629:630	8.5 ms cm-1 EC	617:630	T3: 8.5 ms cm-1 EC	613:630	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	0	14	theme	potato	82:87	arg1	tubers					89:94	cooked potato tubers	75:94	cooked potato tubers	75:94	Agronomical traits, phenolic compounds and antioxidant activity in raw and cooked potato tubers growing under saline conditions.
32248537	0	15	from	activity	55:62	arg1	raw					67:69	raw	67:69	raw	67:69	Agronomical traits, phenolic compounds and antioxidant activity in raw and cooked potato tubers growing under saline conditions.
32248537	8	16	theme	interactions	1216:1227	arg1	method					1249:1254	the interactions treatment × cooking method	1212:1254	the interactions treatment × cooking method	1212:1254	Antioxidants were influenced by cooking method, the interactions treatment × cooking method and variety × cooking method.
32248537	7	17	theme	highest	1119:1125	arg1	antioxidants					1127:1138	the highest antioxidants	1115:1138	the highest antioxidants	1115:1138	The least production and the highest antioxidants were obtained under T3.
32248537	3	18	theme	2.2 ms cm-1	493:503	arg1	EC					505:506	2.2 ms cm-1 EC	493:506	2.2 ms cm-1 EC	493:506	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	6	19	theme	dry	991:993	arg1	matter					995:1000	dry matter	991:1000	dry matter	991:1000	RESULTS Tuber yield, starch, dry matter, ions and antioxidants were significantly influenced by the salinity level and variety.
32248537	6	19	theme	dry	991:993	arg1	RESULTS					962:968	RESULTS Tuber yield, starch, dry matter, ions and antioxidants	962:1023	RESULTS Tuber yield, starch, dry matter, ions and antioxidants	962:1023	RESULTS Tuber yield, starch, dry matter, ions and antioxidants were significantly influenced by the salinity level and variety.
32248537	10	20	theme	Alaska	1471:1476	arg1	tubers					1478:1483	Alaska tubers	1471:1483	Alaska tubers	1471:1483	However, coumaric acid increased in Alaska tubers.
32248537	5	21	theme	liquid	827:832	arg1	chromatography					834:847	high-performance liquid chromatography	810:847	high-performance liquid chromatography (HPLC)	810:854	Carotenoids, total and individual phenolics determined by high-performance liquid chromatography (HPLC), relative antioxidant capacity (RAC) and ions content were analyzed, in both raw and water boiled tubers.
32248537	5	21	theme	liquid	827:832	arg1	HPLC					850:853	HPLC	850:853	HPLC	850:853	Carotenoids, total and individual phenolics determined by high-performance liquid chromatography (HPLC), relative antioxidant capacity (RAC) and ions content were analyzed, in both raw and water boiled tubers.
32248537	2	22	from	effects	318:324	arg1	composition					373:383	the composition	369:383	the composition of potato tubers	369:400	The current study aimed to evaluate the effects of salinity, variety and cooking method in the composition of potato tubers.
32248537	4	23	theme	dry	691:693	arg1	matter					695:700	dry matter	691:700	dry matter	691:700	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	23	theme	dry	691:693	arg1	attributes					671:680	Yield and tuber quality attributes	647:680	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size)	647:734	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	3	24	theme	potato	409:414	arg1	varieties					416:424	Three potato varieties	403:424	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC)	403:631	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	3	24	theme	potato	409:414	arg1	Alaska					447:452	Alaska	447:452	Alaska	447:452	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	3	24	theme	potato	409:414	arg1	Bellini					435:441	Bellini	435:441	Bellini	435:441	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	9	25	theme	different	1326:1334	arg1	response					1336:1343	different response	1326:1343	different response to cooking	1326:1354	Individual phenolic compounds exhibited different response to cooking as quercetin, caffeic acid and catechin decreased significantly after boiling.
32248537	5	26	theme	high-performance	810:825	arg1	chromatography					834:847	high-performance liquid chromatography	810:847	high-performance liquid chromatography (HPLC)	810:854	Carotenoids, total and individual phenolics determined by high-performance liquid chromatography (HPLC), relative antioxidant capacity (RAC) and ions content were analyzed, in both raw and water boiled tubers.
32248537	5	26	theme	high-performance	810:825	arg1	HPLC					850:853	HPLC	850:853	HPLC	850:853	Carotenoids, total and individual phenolics determined by high-performance liquid chromatography (HPLC), relative antioxidant capacity (RAC) and ions content were analyzed, in both raw and water boiled tubers.
32248537	5	27	dep	chromatography	834:847	arg1	content					902:908	content	902:908	content	902:908	Carotenoids, total and individual phenolics determined by high-performance liquid chromatography (HPLC), relative antioxidant capacity (RAC) and ions content were analyzed, in both raw and water boiled tubers.
32248537	0	28	from	compounds	29:37	arg1	raw					67:69	raw	67:69	raw	67:69	Agronomical traits, phenolic compounds and antioxidant activity in raw and cooked potato tubers growing under saline conditions.
32248537	7	29	theme	least	1094:1098	arg1	production					1100:1109	The least production	1090:1109	The least production	1090:1109	The least production and the highest antioxidants were obtained under T3.
32248537	12	30	theme	potato	1646:1651	arg1	production					1653:1662	potato production	1646:1662	potato production	1646:1662	Electromagnetic water may be useful to enhance potato production and tuber quality in areas suffering from water salinization.
32248537	4	31	theme	tuber	657:661	arg1	quality					663:669	tuber quality	657:669	tuber quality	657:669	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	11	32	theme	composition	1586:1596	arg1	determinants					1554:1565	important determinants	1544:1565	important determinants of tuber yield and composition	1544:1596	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	32	theme	composition	1586:1596	arg1	level					1506:1510	CONCLUSION Salinity level	1486:1510	CONCLUSION Salinity level	1486:1510	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	32	theme	composition	1586:1596	arg1	variety					1513:1519	variety	1513:1519	variety	1513:1519	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	32	theme	composition	1586:1596	arg1	method					1533:1538	cooking method	1525:1538	cooking method	1525:1538	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	2	33	theme	method	359:364	arg1	effects					318:324	the effects	314:324	the effects of salinity, variety and cooking method in the composition of potato tubers	314:400	The current study aimed to evaluate the effects of salinity, variety and cooking method in the composition of potato tubers.
32248537	0	34	theme	Agronomical	0:10	arg1	traits					12:17	Agronomical traits	0:17	Agronomical traits	0:17	Agronomical traits, phenolic compounds and antioxidant activity in raw and cooked potato tubers growing under saline conditions.
32248537	12	35	theme	tuber	1668:1672	arg1	quality					1674:1680	tuber quality	1668:1680	tuber quality	1668:1680	Electromagnetic water may be useful to enhance potato production and tuber quality in areas suffering from water salinization.
32248537	8	36	theme	cooking	1241:1247	arg1	method					1249:1254	the interactions treatment × cooking method	1212:1254	the interactions treatment × cooking method	1212:1254	Antioxidants were influenced by cooking method, the interactions treatment × cooking method and variety × cooking method.
32248537	2	37	theme	cooking	351:357	arg1	method					359:364	cooking method	351:364	cooking method	351:364	The current study aimed to evaluate the effects of salinity, variety and cooking method in the composition of potato tubers.
32248537	0	38	theme	phenolic	20:27	arg1	compounds					29:37	phenolic compounds	20:37	phenolic compounds	20:37	Agronomical traits, phenolic compounds and antioxidant activity in raw and cooked potato tubers growing under saline conditions.
32248537	3	39	dep	varieties	416:424	arg1	varieties					416:424	Three potato varieties	403:424	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC)	403:631	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	3	39	dep	varieties	416:424	arg1	Alaska					447:452	Alaska	447:452	Alaska	447:452	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	3	39	dep	varieties	416:424	arg1	Bellini					435:441	Bellini	435:441	Bellini	435:441	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	5	40	theme	relative	857:864	arg1	RAC					888:890	RAC	888:890	RAC	888:890	Carotenoids, total and individual phenolics determined by high-performance liquid chromatography (HPLC), relative antioxidant capacity (RAC) and ions content were analyzed, in both raw and water boiled tubers.
32248537	5	40	theme	relative	857:864	arg1	capacity					878:885	relative antioxidant capacity	857:885	relative antioxidant capacity (RAC)	857:891	Carotenoids, total and individual phenolics determined by high-performance liquid chromatography (HPLC), relative antioxidant capacity (RAC) and ions content were analyzed, in both raw and water boiled tubers.
32248537	2	41	theme	tubers	395:400	arg1	composition					373:383	the composition	369:383	the composition of potato tubers	369:400	The current study aimed to evaluate the effects of salinity, variety and cooking method in the composition of potato tubers.
32248537	0	42	theme	saline	110:115	arg1	conditions					117:126	saline conditions	110:126	saline conditions	110:126	Agronomical traits, phenolic compounds and antioxidant activity in raw and cooked potato tubers growing under saline conditions.
32248537	2	43	theme	salinity	329:336	arg1	effects					318:324	the effects	314:324	the effects of salinity, variety and cooking method in the composition of potato tubers	314:400	The current study aimed to evaluate the effects of salinity, variety and cooking method in the composition of potato tubers.
32248537	2	44	theme	potato	388:393	arg1	tubers					395:400	potato tubers	388:400	potato tubers	388:400	The current study aimed to evaluate the effects of salinity, variety and cooking method in the composition of potato tubers.
32248537	11	45	theme	important	1544:1552	arg1	determinants					1554:1565	important determinants	1544:1565	important determinants of tuber yield and composition	1544:1596	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	45	theme	important	1544:1552	arg1	level					1506:1510	CONCLUSION Salinity level	1486:1510	CONCLUSION Salinity level	1486:1510	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	45	theme	important	1544:1552	arg1	variety					1513:1519	variety	1513:1519	variety	1513:1519	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	45	theme	important	1544:1552	arg1	method					1533:1538	cooking method	1525:1538	cooking method	1525:1538	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	3	46	theme	electromagnetic	586:600	arg1	treatment					602:610	electromagnetic treatment	586:610	electromagnetic treatment	586:610	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	4	47	theme	tuber	724:728	arg1	attributes					671:680	Yield and tuber quality attributes	647:680	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size)	647:734	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	47	theme	tuber	724:728	arg1	size					730:733	tuber size	724:733	tuber size	724:733	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	5	48	theme	individual	775:784	arg1	phenolics					786:794	individual phenolics	775:794	individual phenolics	775:794	Carotenoids, total and individual phenolics determined by high-performance liquid chromatography (HPLC), relative antioxidant capacity (RAC) and ions content were analyzed, in both raw and water boiled tubers.
32248537	9	49	theme	caffeic	1370:1376	arg1	acid					1378:1381	caffeic acid	1370:1381	caffeic acid	1370:1381	Individual phenolic compounds exhibited different response to cooking as quercetin, caffeic acid and catechin decreased significantly after boiling.
32248537	6	50	theme	Tuber	970:974	arg1	yield					976:980	Tuber yield	970:980	Tuber yield	970:980	RESULTS Tuber yield, starch, dry matter, ions and antioxidants were significantly influenced by the salinity level and variety.
32248537	6	50	theme	Tuber	970:974	arg1	RESULTS					962:968	RESULTS Tuber yield, starch, dry matter, ions and antioxidants	962:1023	RESULTS Tuber yield, starch, dry matter, ions and antioxidants	962:1023	RESULTS Tuber yield, starch, dry matter, ions and antioxidants were significantly influenced by the salinity level and variety.
32248537	3	51	theme	ms cm-1	569:575	arg1	EC					577:578	6.3 ms cm-1 EC	565:578	6.3 ms cm-1 EC after electromagnetic treatment	565:610	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	8	52	theme	cooking	1270:1276	arg1	method					1278:1283	× cooking method	1268:1283	× cooking method	1268:1283	Antioxidants were influenced by cooking method, the interactions treatment × cooking method and variety × cooking method.
32248537	1	53	attach	linked	181:186	arg2	compositions					164:175	tuber compositions	158:175	tuber compositions	158:175	BACKGROUND Potato yields and tuber compositions are linked to mechanisms adopted by plants to cope with salinity and often can change after cooking.
32248537	1	53	attach	linked	181:186	arg2	yields					147:152	BACKGROUND Potato yields	129:152	BACKGROUND Potato yields	129:152	BACKGROUND Potato yields and tuber compositions are linked to mechanisms adopted by plants to cope with salinity and often can change after cooking.
32248537	1	53	attach	linked	181:186	arg1	mechanisms					191:200	mechanisms	191:200	mechanisms adopted by plants to cope with salinity	191:240	BACKGROUND Potato yields and tuber compositions are linked to mechanisms adopted by plants to cope with salinity and often can change after cooking.
32248537	8	54	dep	method	1204:1209	arg1	method					1278:1283	× cooking method	1268:1283	× cooking method	1268:1283	Antioxidants were influenced by cooking method, the interactions treatment × cooking method and variety × cooking method.
32248537	11	55	theme	tuber	1570:1574	arg1	yield					1576:1580	tuber yield	1570:1580	tuber yield	1570:1580	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	4	56	dep	attributes	671:680	arg1	starch					683:688	starch	683:688	starch	683:688	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	56	dep	attributes	671:680	arg1	matter					695:700	dry matter	691:700	dry matter	691:700	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	56	dep	attributes	671:680	arg1	density					712:718	specific density	703:718	specific density	703:718	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	56	dep	attributes	671:680	arg1	size					730:733	tuber size	724:733	tuber size	724:733	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	56	dep	attributes	671:680	arg1	attributes					671:680	Yield and tuber quality attributes	647:680	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size)	647:734	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	0	57	theme	antioxidant	43:53	arg1	activity					55:62	antioxidant activity	43:62	antioxidant activity	43:62	Agronomical traits, phenolic compounds and antioxidant activity in raw and cooked potato tubers growing under saline conditions.
32248537	6	58	dep	RESULTS	962:968	arg1	matter					995:1000	dry matter	991:1000	dry matter	991:1000	RESULTS Tuber yield, starch, dry matter, ions and antioxidants were significantly influenced by the salinity level and variety.
32248537	6	58	dep	RESULTS	962:968	arg1	ions					1003:1006	ions	1003:1006	ions	1003:1006	RESULTS Tuber yield, starch, dry matter, ions and antioxidants were significantly influenced by the salinity level and variety.
32248537	6	58	dep	RESULTS	962:968	arg1	yield					976:980	Tuber yield	970:980	Tuber yield	970:980	RESULTS Tuber yield, starch, dry matter, ions and antioxidants were significantly influenced by the salinity level and variety.
32248537	6	58	dep	RESULTS	962:968	arg1	starch					983:988	starch	983:988	starch	983:988	RESULTS Tuber yield, starch, dry matter, ions and antioxidants were significantly influenced by the salinity level and variety.
32248537	6	58	dep	RESULTS	962:968	arg1	antioxidants					1012:1023	antioxidants	1012:1023	antioxidants	1012:1023	RESULTS Tuber yield, starch, dry matter, ions and antioxidants were significantly influenced by the salinity level and variety.
32248537	6	58	dep	RESULTS	962:968	arg1	RESULTS					962:968	RESULTS Tuber yield, starch, dry matter, ions and antioxidants	962:1023	RESULTS Tuber yield, starch, dry matter, ions and antioxidants	962:1023	RESULTS Tuber yield, starch, dry matter, ions and antioxidants were significantly influenced by the salinity level and variety.
32248537	3	59	theme	ms cm-1	517:523	arg1	EC					525:526	8.5 ms cm-1 EC	513:526	8.5 ms cm-1 EC before electromagnetic treatment	513:559	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	3	60	theme	distinct	467:474	arg1	levels					481:486	distinct salt levels	467:486	distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC)	467:631	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	3	61	dep	T1	489:490	arg1	EC					525:526	8.5 ms cm-1 EC	513:526	8.5 ms cm-1 EC before electromagnetic treatment	513:559	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	3	61	dep	T1	489:490	arg1	T3					613:614	T3	613:614	T3: 8.5 ms cm-1 EC	613:630	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	3	61	dep	T1	489:490	arg1	T2					509:510	T2	509:510	T2	509:510	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	3	61	dep	T1	489:490	arg1	EC					577:578	6.3 ms cm-1 EC	565:578	6.3 ms cm-1 EC after electromagnetic treatment	565:610	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	3	61	dep	T1	489:490	arg1	EC					505:506	2.2 ms cm-1 EC	493:506	2.2 ms cm-1 EC	493:506	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	3	62	theme	8.5	617:619	arg1	ms cm-1					621:627	ms cm-1	621:627	ms cm-1	621:627	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	11	63	theme	Salinity	1497:1504	arg1	level					1506:1510	CONCLUSION Salinity level	1486:1510	CONCLUSION Salinity level	1486:1510	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	63	theme	Salinity	1497:1504	arg1	determinants					1554:1565	important determinants	1544:1565	important determinants of tuber yield and composition	1544:1596	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	63	theme	Salinity	1497:1504	arg1	variety					1513:1519	variety	1513:1519	variety	1513:1519	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	63	theme	Salinity	1497:1504	arg1	method					1533:1538	cooking method	1525:1538	cooking method	1525:1538	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	4	64	theme	Yield	647:651	arg1	starch					683:688	starch	683:688	starch	683:688	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	64	theme	Yield	647:651	arg1	matter					695:700	dry matter	691:700	dry matter	691:700	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	64	theme	Yield	647:651	arg1	attributes					671:680	Yield and tuber quality attributes	647:680	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size)	647:734	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	64	theme	Yield	647:651	arg1	size					730:733	tuber size	724:733	tuber size	724:733	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	64	theme	Yield	647:651	arg1	density					712:718	specific density	703:718	specific density	703:718	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	8	65	theme	×	1268:1268	arg1	method					1278:1283	× cooking method	1268:1283	× cooking method	1268:1283	Antioxidants were influenced by cooking method, the interactions treatment × cooking method and variety × cooking method.
32248537	8	66	theme	×	1239:1239	arg1	method					1249:1254	the interactions treatment × cooking method	1212:1254	the interactions treatment × cooking method	1212:1254	Antioxidants were influenced by cooking method, the interactions treatment × cooking method and variety × cooking method.
32248537	0	67	from	tubers	89:94	arg1	raw					67:69	raw	67:69	raw	67:69	Agronomical traits, phenolic compounds and antioxidant activity in raw and cooked potato tubers growing under saline conditions.
32248537	8	68	theme	treatment	1229:1237	arg1	method					1249:1254	the interactions treatment × cooking method	1212:1254	the interactions treatment × cooking method	1212:1254	Antioxidants were influenced by cooking method, the interactions treatment × cooking method and variety × cooking method.
32248537	4	69	theme	quality	663:669	arg1	starch					683:688	starch	683:688	starch	683:688	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	69	theme	quality	663:669	arg1	matter					695:700	dry matter	691:700	dry matter	691:700	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	69	theme	quality	663:669	arg1	attributes					671:680	Yield and tuber quality attributes	647:680	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size)	647:734	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	69	theme	quality	663:669	arg1	size					730:733	tuber size	724:733	tuber size	724:733	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	69	theme	quality	663:669	arg1	density					712:718	specific density	703:718	specific density	703:718	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	1	70	theme	BACKGROUND	129:138	arg1	yields					147:152	BACKGROUND Potato yields	129:152	BACKGROUND Potato yields	129:152	BACKGROUND Potato yields and tuber compositions are linked to mechanisms adopted by plants to cope with salinity and often can change after cooking.
32248537	12	71	theme	water	1706:1710	arg1	salinization					1712:1723	water salinization	1706:1723	water salinization	1706:1723	Electromagnetic water may be useful to enhance potato production and tuber quality in areas suffering from water salinization.
32248537	5	72	theme	boiled	947:952	arg1	tubers					954:959	both raw and water boiled tubers	928:959	tubers	954:959	Carotenoids, total and individual phenolics determined by high-performance liquid chromatography (HPLC), relative antioxidant capacity (RAC) and ions content were analyzed, in both raw and water boiled tubers.
32248537	3	73	theme	electromagnetic	535:549	arg1	treatment					551:559	electromagnetic treatment	535:559	electromagnetic treatment	535:559	Three potato varieties (Spunta, Bellini and Alaska) grown under distinct salt levels (T1: 2.2 ms cm-1 EC, T2: 8.5 ms cm-1 EC before electromagnetic treatment and 6.3 ms cm-1 EC after electromagnetic treatment, T3: 8.5 ms cm-1 EC) were studied.
32248537	11	74	theme	cooking	1525:1531	arg1	determinants					1554:1565	important determinants	1544:1565	important determinants of tuber yield and composition	1544:1596	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	74	theme	cooking	1525:1531	arg1	level					1506:1510	CONCLUSION Salinity level	1486:1510	CONCLUSION Salinity level	1486:1510	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	74	theme	cooking	1525:1531	arg1	variety					1513:1519	variety	1513:1519	variety	1513:1519	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	74	theme	cooking	1525:1531	arg1	method					1533:1538	cooking method	1525:1538	cooking method	1525:1538	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	1	75	theme	Potato	140:145	arg1	yields					147:152	BACKGROUND Potato yields	129:152	BACKGROUND Potato yields	129:152	BACKGROUND Potato yields and tuber compositions are linked to mechanisms adopted by plants to cope with salinity and often can change after cooking.
32248537	11	76	theme	CONCLUSION	1486:1495	arg1	level					1506:1510	CONCLUSION Salinity level	1486:1510	CONCLUSION Salinity level	1486:1510	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	76	theme	CONCLUSION	1486:1495	arg1	determinants					1554:1565	important determinants	1544:1565	important determinants of tuber yield and composition	1544:1596	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	76	theme	CONCLUSION	1486:1495	arg1	variety					1513:1519	variety	1513:1519	variety	1513:1519	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	11	76	theme	CONCLUSION	1486:1495	arg1	method					1533:1538	cooking method	1525:1538	cooking method	1525:1538	CONCLUSION Salinity level, variety and cooking method are important determinants of tuber yield and composition.
32248537	4	77	theme	specific	703:710	arg1	density					712:718	specific density	703:718	specific density	703:718	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	4	77	theme	specific	703:710	arg1	attributes					671:680	Yield and tuber quality attributes	647:680	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size)	647:734	Yield and tuber quality attributes (starch, dry matter, specific density and tuber size) were evaluated.
32248537	13	78	theme	Chemical	1744:1751	arg1	Industry					1753:1760	Chemical Industry	1744:1760	Chemical Industry	1744:1760	© 2020 Society of Chemical Industry.
32248537	2	79	theme	variety	339:345	arg1	effects					318:324	the effects	314:324	the effects of salinity, variety and cooking method in the composition of potato tubers	314:400	The current study aimed to evaluate the effects of salinity, variety and cooking method in the composition of potato tubers.
32248537	12	80	theme	Electromagnetic	1599:1613	arg1	water					1615:1619	Electromagnetic water	1599:1619	Electromagnetic water	1599:1619	Electromagnetic water may be useful to enhance potato production and tuber quality in areas suffering from water salinization.
32248537	9	81	theme	Individual	1286:1295	arg1	compounds					1306:1314	Individual phenolic compounds	1286:1314	Individual phenolic compounds	1286:1314	Individual phenolic compounds exhibited different response to cooking as quercetin, caffeic acid and catechin decreased significantly after boiling.
34283570	7	0	from	environments	1625:1636	arg1	stability					1516:1524	high electrochemical stability	1495:1524	high electrochemical stability	1495:1524	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	7	0	from	environments	1625:1636	arg1	properties					1555:1564	long-lasting antifouling properties	1530:1564	long-lasting antifouling properties	1530:1564	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	4	1	theme	fibroblasts	1074:1084	arg1	proliferation					1057:1069	proliferation	1057:1069	proliferation	1057:1069	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	4	1	theme	fibroblasts	1074:1084	arg1	adhesion					1044:1051	nearly all adhesion	1033:1051	nearly all adhesion	1033:1051	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	3	2	theme	great	545:549	arg1	potential					551:559	LUB coatings great potential	532:559	LUB coatings great potential	532:559	Unlike traditional antiadhesive coatings, LUB coatings do not passivate electrode surfaces, giving LUB coatings great potential for controlling surface fouling of implantable electrode interfaces.
34283570	1	3	theme	clean	270:274	arg1	"					275:275	a "clean"	267:275	a "clean"	267:275	In the field of bionics, the long-term effectiveness of implantable bionic interfaces depends upon maintaining a "clean" and unfouled electrical interface with biological tissues.
34283570	7	4	theme	HA/R-LUB	1579:1586	arg1	coatings					1588:1595	HA/R-LUB coatings	1579:1595	HA/R-LUB coatings	1579:1595	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	4	5	theme	passive	888:894	arg1	environments					924:935	passive and electrically stimulated environments	888:935	passive and electrically stimulated environments	888:935	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	4	6	theme	chondrocytes	1090:1101	arg1	proliferation					1057:1069	proliferation	1057:1069	proliferation	1057:1069	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	4	6	theme	chondrocytes	1090:1101	arg1	adhesion					1044:1051	nearly all adhesion	1033:1051	nearly all adhesion	1033:1051	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	6	7	theme	HA/R-LUB	1321:1328	arg1	films					1340:1344	HA/R-LUB composite films	1321:1344	HA/R-LUB composite films	1321:1344	HA/R-LUB composite films also demonstrated highly effective antifouling performance equal to the R-LUB coatings in both passive and electrically stimulated environments.
34283570	7	8	theme	R-LUB	1569:1573	arg1	stability					1516:1524	high electrochemical stability	1495:1524	high electrochemical stability	1495:1524	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	7	8	theme	R-LUB	1569:1573	arg1	properties					1555:1564	long-lasting antifouling properties	1530:1564	long-lasting antifouling properties	1530:1564	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	4	9	theme	human	842:846	arg1	fibroblasts					856:866	human primary fibroblasts	842:866	human primary fibroblasts	842:866	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	7	10	theme	electrochemical	1500:1514	arg1	stability					1516:1524	high electrochemical stability	1495:1524	high electrochemical stability	1495:1524	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	3	11	theme	surface	577:583	arg1	fouling					585:591	surface fouling	577:591	surface fouling of implantable electrode interfaces	577:627	Unlike traditional antiadhesive coatings, LUB coatings do not passivate electrode surfaces, giving LUB coatings great potential for controlling surface fouling of implantable electrode interfaces.
34283570	4	12	theme	human	724:728	arg1	R-LUB					735:739	R-LUB	735:739	R-LUB	735:739	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	4	12	theme	human	724:728	arg1	LUB					730:732	recombinant human LUB	712:732	recombinant human LUB (R-LUB)	712:740	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	4	13	theme	LUB	699:701	arg1	properties					671:680	the antifouling properties	655:680	the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA	655:792	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	0	14	theme	Stimulated	131:140	arg1	Environments					142:153	Passive and Electrically Stimulated Environments	106:153	Passive and Electrically Stimulated Environments	106:153	Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments.
34283570	3	15	theme	electrode	608:616	arg1	interfaces					618:627	implantable electrode interfaces	596:627	implantable electrode interfaces	596:627	Unlike traditional antiadhesive coatings, LUB coatings do not passivate electrode surfaces, giving LUB coatings great potential for controlling surface fouling of implantable electrode interfaces.
34283570	1	16	theme	implantable	212:222	arg1	interfaces					231:240	implantable bionic interfaces	212:240	implantable bionic interfaces	212:240	In the field of bionics, the long-term effectiveness of implantable bionic interfaces depends upon maintaining a "clean" and unfouled electrical interface with biological tissues.
34283570	4	17	from	electrodes	823:832	arg1	environments					924:935	passive and electrically stimulated environments	888:935	passive and electrically stimulated environments	888:935	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	1	18	theme	interfaces	231:240	arg1	effectiveness					195:207	the long-term effectiveness	181:207	the long-term effectiveness of implantable bionic interfaces	181:240	In the field of bionics, the long-term effectiveness of implantable bionic interfaces depends upon maintaining a "clean" and unfouled electrical interface with biological tissues.
34283570	7	19	from	coatings	1588:1595	arg1	environments					1625:1636	electrically stimulating environments	1600:1636	electrically stimulating environments	1600:1636	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	4	20	theme	hyaluronic	743:752	arg1	HA					760:761	HA	760:761	HA	760:761	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	4	20	theme	hyaluronic	743:752	arg1	acid					754:757	hyaluronic acid	743:757	hyaluronic acid (HA)	743:762	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	6	21	theme	effective	1371:1379	arg1	performance					1393:1403	highly effective antifouling performance	1364:1403	highly effective antifouling performance equal to the R-LUB coatings in both passive and electrically stimulated environments	1364:1488	HA/R-LUB composite films also demonstrated highly effective antifouling performance equal to the R-LUB coatings in both passive and electrically stimulated environments.
34283570	7	22	dep	stability	1516:1524	arg1	The					1491:1493	The	1491:1493	The	1491:1493	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	7	23	theme	implantable	1719:1729	arg1	applications					1738:1749	implantable bionic applications	1719:1749	implantable bionic applications	1719:1749	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	4	24	theme	effective	988:996	arg1	properties					1010:1019	highly effective antifouling properties	981:1019	highly effective antifouling properties	981:1019	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	4	25	from	R-LUB	798:802	arg1	electrodes					823:832	gold electrodes	818:832	gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments	818:935	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	0	26	theme	Gold	87:90	arg1	Electrodes					92:101	Gold Electrodes	87:101	Gold Electrodes in Passive and Electrically Stimulated Environments	87:153	Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments.
34283570	1	27	theme	bionics	172:178	arg1	field					163:167	the field	159:167	the field of bionics	159:178	In the field of bionics, the long-term effectiveness of implantable bionic interfaces depends upon maintaining a "clean" and unfouled electrical interface with biological tissues.
34283570	7	28	theme	unwanted	1693:1700	arg1	adhesion					1707:1714	unwanted cell adhesion	1693:1714	unwanted cell adhesion	1693:1714	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	4	29	theme	R-LUB	953:957	arg1	coatings					959:966	up to 96 h. R-LUB coatings	941:966	up to 96 h. R-LUB coatings	941:966	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	4	30	theme	coatings	779:786	arg1	properties					671:680	the antifouling properties	655:680	the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA	655:792	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	6	31	from	coatings	1424:1431	arg1	environments					1477:1488	both passive and electrically stimulated environments	1436:1488	both passive and electrically stimulated environments	1436:1488	HA/R-LUB composite films also demonstrated highly effective antifouling performance equal to the R-LUB coatings in both passive and electrically stimulated environments.
34283570	4	32	theme	HA	791:792	arg1	properties					671:680	the antifouling properties	655:680	the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA	655:792	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	3	33	theme	LUB	475:477	arg1	coatings					479:486	LUB coatings	475:486	LUB coatings	475:486	Unlike traditional antiadhesive coatings, LUB coatings do not passivate electrode surfaces, giving LUB coatings great potential for controlling surface fouling of implantable electrode interfaces.
34283570	6	34	theme	R-LUB	1418:1422	arg1	coatings					1424:1431	the R-LUB coatings	1414:1431	the R-LUB coatings in both passive and electrically stimulated environments	1414:1488	HA/R-LUB composite films also demonstrated highly effective antifouling performance equal to the R-LUB coatings in both passive and electrically stimulated environments.
34283570	0	35	theme	Hyaluronic	40:49	arg1	Coatings					75:82	Hyaluronic Acid-Lubricin Composite Coatings	40:82	Hyaluronic Acid-Lubricin Composite Coatings	40:82	Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments.
34283570	2	36	theme	impressive	398:407	arg1	properties					421:430	impressive antifouling properties	398:430	impressive antifouling properties	398:430	Lubricin (LUB) is an innately biocompatible glycoprotein with impressive antifouling properties.
34283570	0	37	theme	Cellular	0:7	arg1	Interactions					9:20	Cellular Interactions	0:20	Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments.	0:154	Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments.
34283570	1	38	theme	unfouled	281:288	arg1	interface					301:309	unfouled electrical interface	281:309	unfouled electrical interface	281:309	In the field of bionics, the long-term effectiveness of implantable bionic interfaces depends upon maintaining a "clean" and unfouled electrical interface with biological tissues.
34283570	3	39	theme	traditional	440:450	arg1	coatings					465:472	traditional antiadhesive coatings	440:472	traditional antiadhesive coatings	440:472	Unlike traditional antiadhesive coatings, LUB coatings do not passivate electrode surfaces, giving LUB coatings great potential for controlling surface fouling of implantable electrode interfaces.
34283570	1	40	theme	biological	316:325	arg1	tissues					327:333	biological tissues	316:333	biological tissues	316:333	In the field of bionics, the long-term effectiveness of implantable bionic interfaces depends upon maintaining a "clean" and unfouled electrical interface with biological tissues.
34283570	1	41	with	"	275:275	arg1	tissues					327:333	biological tissues	316:333	biological tissues	316:333	In the field of bionics, the long-term effectiveness of implantable bionic interfaces depends upon maintaining a "clean" and unfouled electrical interface with biological tissues.
34283570	0	42	theme	Acid-Lubricin	51:63	arg1	Coatings					75:82	Hyaluronic Acid-Lubricin Composite Coatings	40:82	Hyaluronic Acid-Lubricin Composite Coatings	40:82	Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments.
34283570	4	43	theme	biphasic	1114:1121	arg1	stimulation					1134:1144	biphasic electrical stimulation	1114:1144	biphasic electrical stimulation	1114:1144	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	2	44	with	glycoprotein	380:391	arg1	properties					421:430	impressive antifouling properties	398:430	impressive antifouling properties	398:430	Lubricin (LUB) is an innately biocompatible glycoprotein with impressive antifouling properties.
34283570	4	45	theme	antifouling	659:669	arg1	properties					671:680	the antifouling properties	655:680	the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA	655:792	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	7	46	theme	coatings	1588:1595	arg1	stability					1516:1524	high electrochemical stability	1495:1524	high electrochemical stability	1495:1524	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	7	46	theme	coatings	1588:1595	arg1	properties					1555:1564	long-lasting antifouling properties	1530:1564	long-lasting antifouling properties	1530:1564	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	3	47	theme	coatings	536:543	arg1	potential					551:559	LUB coatings great potential	532:559	LUB coatings great potential	532:559	Unlike traditional antiadhesive coatings, LUB coatings do not passivate electrode surfaces, giving LUB coatings great potential for controlling surface fouling of implantable electrode interfaces.
34283570	5	48	theme	antifouling	1233:1243	arg1	properties					1245:1254	sustained antifouling properties	1223:1254	sustained antifouling properties	1223:1254	N-LUB coatings, while showing efficacy in the short term, failed to produce sustained antifouling properties against fibroblasts or chondrocytes over longer periods of time.
34283570	6	49	theme	composite	1330:1338	arg1	films					1340:1344	HA/R-LUB composite films	1321:1344	HA/R-LUB composite films	1321:1344	HA/R-LUB composite films also demonstrated highly effective antifouling performance equal to the R-LUB coatings in both passive and electrically stimulated environments.
34283570	7	50	theme	long-lasting	1530:1541	arg1	properties					1555:1564	long-lasting antifouling properties	1530:1564	long-lasting antifouling properties	1530:1564	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	7	51	theme	antifouling	1543:1553	arg1	properties					1555:1564	long-lasting antifouling properties	1530:1564	long-lasting antifouling properties	1530:1564	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	1	52	with	interface	301:309	arg1	tissues					327:333	biological tissues	316:333	biological tissues	316:333	In the field of bionics, the long-term effectiveness of implantable bionic interfaces depends upon maintaining a "clean" and unfouled electrical interface with biological tissues.
34283570	6	53	theme	passive	1441:1447	arg1	environments					1477:1488	both passive and electrically stimulated environments	1436:1488	both passive and electrically stimulated environments	1436:1488	HA/R-LUB composite films also demonstrated highly effective antifouling performance equal to the R-LUB coatings in both passive and electrically stimulated environments.
34283570	3	54	theme	interfaces	618:627	arg1	fouling					585:591	surface fouling	577:591	surface fouling of implantable electrode interfaces	577:627	Unlike traditional antiadhesive coatings, LUB coatings do not passivate electrode surfaces, giving LUB coatings great potential for controlling surface fouling of implantable electrode interfaces.
34283570	1	55	theme	long-term	185:193	arg1	effectiveness					195:207	the long-term effectiveness	181:207	the long-term effectiveness of implantable bionic interfaces	181:240	In the field of bionics, the long-term effectiveness of implantable bionic interfaces depends upon maintaining a "clean" and unfouled electrical interface with biological tissues.
34283570	7	56	from	properties	1555:1564	arg1	environments					1625:1636	electrically stimulating environments	1600:1636	electrically stimulating environments	1600:1636	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	4	57	theme	primary	848:854	arg1	fibroblasts					856:866	human primary fibroblasts	842:866	human primary fibroblasts	842:866	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	7	58	theme	high	1495:1498	arg1	stability					1516:1524	high electrochemical stability	1495:1524	high electrochemical stability	1495:1524	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	4	59	theme	recombinant	712:722	arg1	R-LUB					735:739	R-LUB	735:739	R-LUB	735:739	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	4	59	theme	recombinant	712:722	arg1	LUB					730:732	recombinant human LUB	712:732	recombinant human LUB (R-LUB)	712:740	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	3	60	theme	implantable	596:606	arg1	interfaces					618:627	implantable electrode interfaces	596:627	implantable electrode interfaces	596:627	Unlike traditional antiadhesive coatings, LUB coatings do not passivate electrode surfaces, giving LUB coatings great potential for controlling surface fouling of implantable electrode interfaces.
34283570	7	61	from	R-LUB	1569:1573	arg1	environments					1625:1636	electrically stimulating environments	1600:1636	electrically stimulating environments	1600:1636	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	0	62	from	Electrodes	92:101	arg1	Environments					142:153	Passive and Electrically Stimulated Environments	106:153	Passive and Electrically Stimulated Environments	106:153	Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments.
34283570	4	63	theme	native	692:697	arg1	N-LUB					704:708	N-LUB	704:708	N-LUB	704:708	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	4	63	theme	native	692:697	arg1	LUB					699:701	bovine native LUB	685:701	bovine native LUB (N-LUB)	685:709	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	6	64	theme	equal	1405:1409	arg1	performance					1393:1403	highly effective antifouling performance	1364:1403	highly effective antifouling performance equal to the R-LUB coatings in both passive and electrically stimulated environments	1364:1488	HA/R-LUB composite films also demonstrated highly effective antifouling performance equal to the R-LUB coatings in both passive and electrically stimulated environments.
34283570	1	65	theme	bionic	224:229	arg1	interfaces					231:240	implantable bionic interfaces	212:240	implantable bionic interfaces	212:240	In the field of bionics, the long-term effectiveness of implantable bionic interfaces depends upon maintaining a "clean" and unfouled electrical interface with biological tissues.
34283570	4	66	dep	96	947:948	arg1	to					944:945	to	944:945	to	944:945	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	6	67	theme	antifouling	1381:1391	arg1	performance					1393:1403	highly effective antifouling performance	1364:1403	highly effective antifouling performance equal to the R-LUB coatings in both passive and electrically stimulated environments	1364:1488	HA/R-LUB composite films also demonstrated highly effective antifouling performance equal to the R-LUB coatings in both passive and electrically stimulated environments.
34283570	7	68	theme	bionic	1731:1736	arg1	applications					1738:1749	implantable bionic applications	1719:1749	implantable bionic applications	1719:1749	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	4	69	theme	stimulated	913:922	arg1	environments					924:935	passive and electrically stimulated environments	888:935	passive and electrically stimulated environments	888:935	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	4	70	theme	acid	754:757	arg1	properties					671:680	the antifouling properties	655:680	the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA	655:792	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	6	71	theme	stimulated	1466:1475	arg1	environments					1477:1488	both passive and electrically stimulated environments	1436:1488	both passive and electrically stimulated environments	1436:1488	HA/R-LUB composite films also demonstrated highly effective antifouling performance equal to the R-LUB coatings in both passive and electrically stimulated environments.
34283570	7	72	theme	cell	1702:1705	arg1	adhesion					1707:1714	unwanted cell adhesion	1693:1714	unwanted cell adhesion	1693:1714	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	4	73	theme	LUB	730:732	arg1	properties					671:680	the antifouling properties	655:680	the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA	655:792	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	7	74	from	stability	1516:1524	arg1	environments					1625:1636	electrically stimulating environments	1600:1636	electrically stimulating environments	1600:1636	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	4	75	theme	antifouling	998:1008	arg1	properties					1010:1019	highly effective antifouling properties	981:1019	highly effective antifouling properties	981:1019	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	0	76	from	Interactions	9:20	arg1	Electrodes					92:101	Gold Electrodes	87:101	Gold Electrodes in Passive and Electrically Stimulated Environments	87:153	Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments.
34283570	5	77	theme	time	1315:1318	arg1	periods					1304:1310	longer periods	1297:1310	longer periods of time	1297:1318	N-LUB coatings, while showing efficacy in the short term, failed to produce sustained antifouling properties against fibroblasts or chondrocytes over longer periods of time.
34283570	0	78	theme	Passive	106:112	arg1	Environments					142:153	Passive and Electrically Stimulated Environments	106:153	Passive and Electrically Stimulated Environments	106:153	Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments.
34283570	7	79	theme	coatings	1668:1675	arg1	potential					1649:1657	the potential	1645:1657	the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications	1645:1749	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	4	80	theme	composite	769:777	arg1	coatings					779:786	composite coatings	769:786	composite coatings	769:786	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	5	81	theme	N-LUB	1147:1151	arg1	coatings					1153:1160	N-LUB coatings	1147:1160	N-LUB coatings	1147:1160	N-LUB coatings, while showing efficacy in the short term, failed to produce sustained antifouling properties against fibroblasts or chondrocytes over longer periods of time.
34283570	2	82	theme	antifouling	409:419	arg1	properties					421:430	impressive antifouling properties	398:430	impressive antifouling properties	398:430	Lubricin (LUB) is an innately biocompatible glycoprotein with impressive antifouling properties.
34283570	1	83	theme	electrical	290:299	arg1	interface					301:309	unfouled electrical interface	281:309	unfouled electrical interface	281:309	In the field of bionics, the long-term effectiveness of implantable bionic interfaces depends upon maintaining a "clean" and unfouled electrical interface with biological tissues.
34283570	2	84	gly	glycoprotein	380:391	arg1	Lubricin					336:343	Lubricin	336:343	Lubricin (LUB)	336:349	Lubricin (LUB) is an innately biocompatible glycoprotein with impressive antifouling properties.
34283570	2	84	gly	glycoprotein	380:391	arg1	glycoprotein					380:391	an innately biocompatible glycoprotein	354:391	an innately biocompatible glycoprotein with impressive antifouling properties	354:430	Lubricin (LUB) is an innately biocompatible glycoprotein with impressive antifouling properties.
34283570	3	85	theme	electrode	505:513	arg1	surfaces					515:522	electrode surfaces	505:522	electrode surfaces	505:522	Unlike traditional antiadhesive coatings, LUB coatings do not passivate electrode surfaces, giving LUB coatings great potential for controlling surface fouling of implantable electrode interfaces.
34283570	5	86	from	efficacy	1177:1184	arg1	term					1199:1202	the short term	1189:1202	the short term	1189:1202	N-LUB coatings, while showing efficacy in the short term, failed to produce sustained antifouling properties against fibroblasts or chondrocytes over longer periods of time.
34283570	5	87	theme	sustained	1223:1231	arg1	properties					1245:1254	sustained antifouling properties	1223:1254	sustained antifouling properties	1223:1254	N-LUB coatings, while showing efficacy in the short term, failed to produce sustained antifouling properties against fibroblasts or chondrocytes over longer periods of time.
34283570	3	88	theme	antiadhesive	452:463	arg1	coatings					465:472	traditional antiadhesive coatings	440:472	traditional antiadhesive coatings	440:472	Unlike traditional antiadhesive coatings, LUB coatings do not passivate electrode surfaces, giving LUB coatings great potential for controlling surface fouling of implantable electrode interfaces.
34283570	5	89	dep	coatings	1153:1160	arg1	showing					1169:1175	showing	1169:1175	showing efficacy in the short term	1169:1202	N-LUB coatings, while showing efficacy in the short term, failed to produce sustained antifouling properties against fibroblasts or chondrocytes over longer periods of time.
34283570	0	90	theme	Composite	65:73	arg1	Coatings					75:82	Hyaluronic Acid-Lubricin Composite Coatings	40:82	Hyaluronic Acid-Lubricin Composite Coatings	40:82	Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments.
34283570	5	91	theme	short	1193:1197	arg1	term					1199:1202	the short term	1189:1202	the short term	1189:1202	N-LUB coatings, while showing efficacy in the short term, failed to produce sustained antifouling properties against fibroblasts or chondrocytes over longer periods of time.
34283570	4	92	theme	gold	818:821	arg1	electrodes					823:832	gold electrodes	818:832	gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments	818:935	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	0	93	with	Interactions	9:20	arg1	Coatings					75:82	Hyaluronic Acid-Lubricin Composite Coatings	40:82	Hyaluronic Acid-Lubricin Composite Coatings	40:82	Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments.
34283570	0	93	with	Interactions	9:20	arg1	Lubricin					27:34	Lubricin	27:34	Lubricin	27:34	Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments.
34283570	3	94	theme	LUB	532:534	arg1	potential					551:559	LUB coatings great potential	532:559	LUB coatings great potential	532:559	Unlike traditional antiadhesive coatings, LUB coatings do not passivate electrode surfaces, giving LUB coatings great potential for controlling surface fouling of implantable electrode interfaces.
34283570	7	95	theme	stimulating	1613:1623	arg1	environments					1625:1636	electrically stimulating environments	1600:1636	electrically stimulating environments	1600:1636	The high electrochemical stability and long-lasting antifouling properties of R-LUB and HA/R-LUB coatings in electrically stimulating environments reveal the potential of these coatings for controlling unwanted cell adhesion in implantable bionic applications.
34283570	4	96	theme	electrical	1123:1132	arg1	stimulation					1134:1144	biphasic electrical stimulation	1114:1144	biphasic electrical stimulation	1114:1144	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	4	97	theme	bovine	685:690	arg1	N-LUB					704:708	N-LUB	704:708	N-LUB	704:708	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	4	97	theme	bovine	685:690	arg1	LUB					699:701	bovine native LUB	685:701	bovine native LUB (N-LUB)	685:709	This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary fibroblasts and chondrocytes in passive and electrically stimulated environments for up to 96 h. R-LUB coatings demonstrated highly effective antifouling properties, preventing nearly all adhesion and proliferation of fibroblasts and chondrocytes even under biphasic electrical stimulation.
34283570	2	98	theme	biocompatible	366:378	arg1	Lubricin					336:343	Lubricin	336:343	Lubricin (LUB)	336:349	Lubricin (LUB) is an innately biocompatible glycoprotein with impressive antifouling properties.
34283570	2	98	theme	biocompatible	366:378	arg1	glycoprotein					380:391	an innately biocompatible glycoprotein	354:391	an innately biocompatible glycoprotein with impressive antifouling properties	354:430	Lubricin (LUB) is an innately biocompatible glycoprotein with impressive antifouling properties.
34283570	5	99	theme	longer	1297:1302	arg1	periods					1304:1310	longer periods	1297:1310	longer periods of time	1297:1318	N-LUB coatings, while showing efficacy in the short term, failed to produce sustained antifouling properties against fibroblasts or chondrocytes over longer periods of time.
33010579	4	0	theme	digestible	1022:1031	arg1	starch					1033:1038	rapidly digestible starch	1014:1038	rapidly digestible starch	1014:1038	In vitro digestibility analysis showed that the total content of rapidly digestible starch and slowly digestible starch was increased, whereas the content of resistant starch was decreased.
33010579	3	1	theme	scanning	491:498	arg1	microscopy					509:518	scanning electron microscopy	491:518	scanning electron microscopy	491:518	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	5	2	theme	ultrasonic	1311:1320	arg1	treatment					1322:1330	ultrasonic treatment	1311:1330	ultrasonic treatment	1311:1330	Overall, ultrasonic treatment substantially reduced the enzymatic resistance of RS4, indicating that RS4 was not stability against the non-thermal processing technology of ultrasonic treatment.
33010579	4	3	theme	In	949:950	arg1	analysis					972:979	In vitro digestibility analysis	949:979	In vitro digestibility analysis	949:979	In vitro digestibility analysis showed that the total content of rapidly digestible starch and slowly digestible starch was increased, whereas the content of resistant starch was decreased.
33010579	3	4	theme	electron	500:507	arg1	microscopy					509:518	scanning electron microscopy	491:518	scanning electron microscopy	491:518	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	5	from	analysis	535:542	arg1	Results					478:484	Results	478:484	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy	478:672	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	6	theme	helical	858:864	arg1	orders					866:871	the helical orders	854:871	the helical orders	854:871	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	0	7	theme	processing	96:105	arg1	technology					107:116	a non-thermal processing technology	82:116	a non-thermal processing technology of ultrasonic treatment	82:140	Modulating the in vitro digestibility of chemically modified starch ingredient by a non-thermal processing technology of ultrasonic treatment.
33010579	1	8	theme	enzymatic	331:339	arg1	resistance					341:350	the enzymatic resistance	327:350	the enzymatic resistance of RS4	327:357	Chemically modified starch (RS4) was commercially available as a food ingredient, however, there was a lack of knowledge on how ultrasonic treatment (non-thermal technology) modulated the enzymatic resistance of RS4.
33010579	3	9	theme	short-range	891:901	arg1	orders					913:918	the short-range molecular orders	887:918	the short-range molecular orders of ultrasonic-processed RS4	887:946	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	0	10	theme	non-thermal	84:94	arg1	technology					107:116	a non-thermal processing technology	82:116	a non-thermal processing technology of ultrasonic treatment	82:140	Modulating the in vitro digestibility of chemically modified starch ingredient by a non-thermal processing technology of ultrasonic treatment.
33010579	3	11	from	microscopy	509:518	arg1	Results					478:484	Results	478:484	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy	478:672	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	12	theme	RS4	944:946	arg1	orders					913:918	the short-range molecular orders	887:918	the short-range molecular orders of ultrasonic-processed RS4	887:946	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	4	13	theme	total	997:1001	arg1	content					1003:1009	the total content	993:1009	the total content of rapidly digestible starch and slowly digestible starch	993:1067	In vitro digestibility analysis showed that the total content of rapidly digestible starch and slowly digestible starch was increased, whereas the content of resistant starch was decreased.
33010579	3	14	theme	apparent	754:761	arg1	content					771:777	the apparent amylose content	750:777	the apparent amylose content	750:777	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	15	theme	particle	521:528	arg1	analysis					535:542	particle size analysis	521:542	particle size analysis	521:542	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	16	from	calorimetry	617:627	arg1	Results					478:484	Results	478:484	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy	478:672	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	4	17	dep	In	949:950	arg1	vitro					952:956	vitro	952:956	vitro	952:956	In vitro digestibility analysis showed that the total content of rapidly digestible starch and slowly digestible starch was increased, whereas the content of resistant starch was decreased.
33010579	1	18	theme	RS4	355:357	arg1	resistance					341:350	the enzymatic resistance	327:350	the enzymatic resistance of RS4	327:357	Chemically modified starch (RS4) was commercially available as a food ingredient, however, there was a lack of knowledge on how ultrasonic treatment (non-thermal technology) modulated the enzymatic resistance of RS4.
33010579	4	19	dep	increased	1073:1081	arg1	whereas					1084:1090	whereas	1084:1090	whereas	1084:1090	In vitro digestibility analysis showed that the total content of rapidly digestible starch and slowly digestible starch was increased, whereas the content of resistant starch was decreased.
33010579	3	20	theme	size	530:533	arg1	analysis					535:542	particle size analysis	521:542	particle size analysis	521:542	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	5	21	theme	ultrasonic	1148:1157	arg1	treatment					1159:1167	ultrasonic treatment	1148:1167	ultrasonic treatment	1148:1167	Overall, ultrasonic treatment substantially reduced the enzymatic resistance of RS4, indicating that RS4 was not stability against the non-thermal processing technology of ultrasonic treatment.
33010579	3	22	dep	remained	707:714	arg1	increased					740:748	increased	740:748	increased the apparent amylose content	740:777	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	22	dep	remained	707:714	arg1	enhanced					878:885	enhanced	878:885	enhanced the short-range molecular orders of ultrasonic-processed RS4	878:946	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	22	dep	remained	707:714	arg1	reduced					780:786	reduced	780:786	reduced the particle size	780:804	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	22	dep	remained	707:714	arg1	destroyed					807:815	destroyed	807:815	destroyed the crystalline structure	807:841	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	22	dep	remained	707:714	arg1	decreased					844:852	decreased	844:852	decreased the helical orders	844:871	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	5	23	theme	RS4	1219:1221	arg1	resistance					1205:1214	the enzymatic resistance	1191:1214	the enzymatic resistance of RS4	1191:1221	Overall, ultrasonic treatment substantially reduced the enzymatic resistance of RS4, indicating that RS4 was not stability against the non-thermal processing technology of ultrasonic treatment.
33010579	4	24	theme	starch	1062:1067	arg1	content					1003:1009	the total content	993:1009	the total content of rapidly digestible starch and slowly digestible starch	993:1067	In vitro digestibility analysis showed that the total content of rapidly digestible starch and slowly digestible starch was increased, whereas the content of resistant starch was decreased.
33010579	1	25	theme	knowledge	254:262	arg1	lack					246:249	a lack	244:249	a lack of knowledge on how ultrasonic treatment (non-thermal technology) modulated the enzymatic resistance of RS4	244:357	Chemically modified starch (RS4) was commercially available as a food ingredient, however, there was a lack of knowledge on how ultrasonic treatment (non-thermal technology) modulated the enzymatic resistance of RS4.
33010579	4	26	theme	digestible	1051:1060	arg1	starch					1062:1067	slowly digestible starch	1044:1067	slowly digestible starch	1044:1067	In vitro digestibility analysis showed that the total content of rapidly digestible starch and slowly digestible starch was increased, whereas the content of resistant starch was decreased.
33010579	2	27	theme	ultrasonic	407:416	arg1	treatment					418:426	ultrasonic treatment	407:426	ultrasonic treatment	407:426	In this study, structural change of RS4 during ultrasonic treatment and its resulting digestibility was investigated.
33010579	0	28	theme	treatment	132:140	arg1	technology					107:116	a non-thermal processing technology	82:116	a non-thermal processing technology of ultrasonic treatment	82:140	Modulating the in vitro digestibility of chemically modified starch ingredient by a non-thermal processing technology of ultrasonic treatment.
33010579	3	29	theme	chemical	545:552	arg1	analysis					566:573	chemical composition analysis	545:573	chemical composition analysis	545:573	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	30	from	diffraction	582:592	arg1	Results					478:484	Results	478:484	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy	478:672	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	2	31	theme	RS4	396:398	arg1	change					386:391	structural change	375:391	structural change of RS4 during ultrasonic treatment and its resulting digestibility	375:458	In this study, structural change of RS4 during ultrasonic treatment and its resulting digestibility was investigated.
33010579	0	32	theme	in	15:16	arg1	digestibility					24:36	the in vitro digestibility	11:36	the in vitro digestibility of chemically modified starch ingredient	11:77	Modulating the in vitro digestibility of chemically modified starch ingredient by a non-thermal processing technology of ultrasonic treatment.
33010579	3	33	theme	amylose	763:769	arg1	content					771:777	the apparent amylose content	750:777	the apparent amylose content	750:777	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	0	34	theme	ultrasonic	121:130	arg1	treatment					132:140	ultrasonic treatment	121:140	ultrasonic treatment	121:140	Modulating the in vitro digestibility of chemically modified starch ingredient by a non-thermal processing technology of ultrasonic treatment.
33010579	3	35	theme	infrared	652:659	arg1	spectroscopy					661:672	infrared spectroscopy	652:672	infrared spectroscopy	652:672	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	36	theme	composition	554:564	arg1	analysis					566:573	chemical composition analysis	545:573	chemical composition analysis	545:573	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	1	37	theme	ultrasonic	271:280	arg1	treatment					282:290	ultrasonic treatment	271:290	ultrasonic treatment (non-thermal technology)	271:315	Chemically modified starch (RS4) was commercially available as a food ingredient, however, there was a lack of knowledge on how ultrasonic treatment (non-thermal technology) modulated the enzymatic resistance of RS4.
33010579	1	37	theme	ultrasonic	271:280	arg1	technology					305:314	non-thermal technology	293:314	non-thermal technology	293:314	Chemically modified starch (RS4) was commercially available as a food ingredient, however, there was a lack of knowledge on how ultrasonic treatment (non-thermal technology) modulated the enzymatic resistance of RS4.
33010579	5	38	theme	treatment	1322:1330	arg1	technology					1297:1306	the non-thermal processing technology	1270:1306	the non-thermal processing technology of ultrasonic treatment	1270:1330	Overall, ultrasonic treatment substantially reduced the enzymatic resistance of RS4, indicating that RS4 was not stability against the non-thermal processing technology of ultrasonic treatment.
33010579	1	39	theme	food	208:211	arg1	ingredient					213:222	a food ingredient	206:222	a food ingredient	206:222	Chemically modified starch (RS4) was commercially available as a food ingredient, however, there was a lack of knowledge on how ultrasonic treatment (non-thermal technology) modulated the enzymatic resistance of RS4.
33010579	4	40	theme	starch	1033:1038	arg1	content					1003:1009	the total content	993:1009	the total content of rapidly digestible starch and slowly digestible starch	993:1067	In vitro digestibility analysis showed that the total content of rapidly digestible starch and slowly digestible starch was increased, whereas the content of resistant starch was decreased.
33010579	5	41	theme	enzymatic	1195:1203	arg1	resistance					1205:1214	the enzymatic resistance	1191:1214	the enzymatic resistance of RS4	1191:1221	Overall, ultrasonic treatment substantially reduced the enzymatic resistance of RS4, indicating that RS4 was not stability against the non-thermal processing technology of ultrasonic treatment.
33010579	4	42	theme	digestibility	958:970	arg1	analysis					972:979	In vitro digestibility analysis	949:979	In vitro digestibility analysis	949:979	In vitro digestibility analysis showed that the total content of rapidly digestible starch and slowly digestible starch was increased, whereas the content of resistant starch was decreased.
33010579	3	43	theme	differential	595:606	arg1	calorimetry					617:627	differential scanning calorimetry	595:627	differential scanning calorimetry	595:627	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	2	44	theme	structural	375:384	arg1	change					386:391	structural change	375:391	structural change of RS4 during ultrasonic treatment and its resulting digestibility	375:458	In this study, structural change of RS4 during ultrasonic treatment and its resulting digestibility was investigated.
33010579	2	45	theme	resulting	436:444	arg1	digestibility					446:458	its resulting digestibility	432:458	its resulting digestibility	432:458	In this study, structural change of RS4 during ultrasonic treatment and its resulting digestibility was investigated.
33010579	3	46	from	Fourier	634:640	arg1	Results					478:484	Results	478:484	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy	478:672	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	0	47	theme	starch	61:66	arg1	ingredient					68:77	chemically modified starch ingredient	41:77	chemically modified starch ingredient	41:77	Modulating the in vitro digestibility of chemically modified starch ingredient by a non-thermal processing technology of ultrasonic treatment.
33010579	3	48	theme	X-ray	576:580	arg1	diffraction					582:592	X-ray diffraction	576:592	X-ray diffraction	576:592	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	1	49	theme	non-thermal	293:303	arg1	treatment					282:290	ultrasonic treatment	271:290	ultrasonic treatment (non-thermal technology)	271:315	Chemically modified starch (RS4) was commercially available as a food ingredient, however, there was a lack of knowledge on how ultrasonic treatment (non-thermal technology) modulated the enzymatic resistance of RS4.
33010579	1	49	theme	non-thermal	293:303	arg1	technology					305:314	non-thermal technology	293:314	non-thermal technology	293:314	Chemically modified starch (RS4) was commercially available as a food ingredient, however, there was a lack of knowledge on how ultrasonic treatment (non-thermal technology) modulated the enzymatic resistance of RS4.
33010579	3	50	theme	ultrasonic	686:695	arg1	treatment					697:705	ultrasonic treatment	686:705	ultrasonic treatment	686:705	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	4	51	theme	starch	1117:1122	arg1	content					1096:1102	the content	1092:1102	the content of resistant starch	1092:1122	In vitro digestibility analysis showed that the total content of rapidly digestible starch and slowly digestible starch was increased, whereas the content of resistant starch was decreased.
33010579	3	52	theme	particle	792:799	arg1	size					801:804	the particle size	788:804	the particle size	788:804	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	53	dep	microscopy	509:518	arg1	transform					642:650	transform	642:650	transform infrared spectroscopy	642:672	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	54	theme	crystalline	821:831	arg1	structure					833:841	the crystalline structure	817:841	the crystalline structure	817:841	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	0	55	dep	in	15:16	arg1	vitro					18:22	vitro	18:22	vitro	18:22	Modulating the in vitro digestibility of chemically modified starch ingredient by a non-thermal processing technology of ultrasonic treatment.
33010579	3	56	from	analysis	566:573	arg1	Results					478:484	Results	478:484	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy	478:672	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	5	57	theme	non-thermal	1274:1284	arg1	technology					1297:1306	the non-thermal processing technology	1270:1306	the non-thermal processing technology of ultrasonic treatment	1270:1330	Overall, ultrasonic treatment substantially reduced the enzymatic resistance of RS4, indicating that RS4 was not stability against the non-thermal processing technology of ultrasonic treatment.
33010579	0	58	theme	ingredient	68:77	arg1	digestibility					24:36	the in vitro digestibility	11:36	the in vitro digestibility of chemically modified starch ingredient	11:77	Modulating the in vitro digestibility of chemically modified starch ingredient by a non-thermal processing technology of ultrasonic treatment.
33010579	3	59	theme	scanning	608:615	arg1	calorimetry					617:627	differential scanning calorimetry	595:627	differential scanning calorimetry	595:627	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	1	60	theme	modified	154:161	arg1	starch					163:168	Chemically modified starch	143:168	Chemically modified starch (RS4)	143:174	Chemically modified starch (RS4) was commercially available as a food ingredient, however, there was a lack of knowledge on how ultrasonic treatment (non-thermal technology) modulated the enzymatic resistance of RS4.
33010579	1	60	theme	modified	154:161	arg1	RS4					171:173	RS4	171:173	RS4	171:173	Chemically modified starch (RS4) was commercially available as a food ingredient, however, there was a lack of knowledge on how ultrasonic treatment (non-thermal technology) modulated the enzymatic resistance of RS4.
33010579	4	61	theme	resistant	1107:1115	arg1	starch					1117:1122	resistant starch	1107:1122	resistant starch	1107:1122	In vitro digestibility analysis showed that the total content of rapidly digestible starch and slowly digestible starch was increased, whereas the content of resistant starch was decreased.
33010579	5	62	theme	processing	1286:1295	arg1	technology					1297:1306	the non-thermal processing technology	1270:1306	the non-thermal processing technology of ultrasonic treatment	1270:1330	Overall, ultrasonic treatment substantially reduced the enzymatic resistance of RS4, indicating that RS4 was not stability against the non-thermal processing technology of ultrasonic treatment.
33010579	0	63	theme	modified	52:59	arg1	ingredient					68:77	chemically modified starch ingredient	41:77	chemically modified starch ingredient	41:77	Modulating the in vitro digestibility of chemically modified starch ingredient by a non-thermal processing technology of ultrasonic treatment.
33010579	3	64	theme	granule	720:726	arg1	morphology					728:737	the granule morphology	716:737	the granule morphology	716:737	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33010579	3	65	theme	molecular	903:911	arg1	orders					913:918	the short-range molecular orders	887:918	the short-range molecular orders of ultrasonic-processed RS4	887:946	Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4.
33278981	6	0	theme	3D	905:906	arg1	printing					908:915	3D printing	905:915	3D printing	905:915	Furthermore, we prepared two composite hydrogels for 3D printing by blending CNC with high/low methoxy pectin (HMP/LMP).
33278981	4	1	theme	%	688:688	arg1	%					693:693	72 %-73 %	685:693	72 %-73 %	685:693	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	4	1	theme	%	688:688	arg1	degree					662:667	a high degree	655:667	a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction	655:740	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	1	2	theme	tremendous	149:158	arg1	bioresource					232:242	an attractive green bioresource	212:242	an attractive green bioresource	212:242	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	1	2	theme	tremendous	149:158	arg1	potential					160:168	tremendous potential	149:168	tremendous potential in chemical, material, and food fields	149:207	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	4	3	theme	%	585:585	arg1	hydrogels					591:599	20 wt% CNC hydrogels	580:599	20 wt% CNC hydrogels	580:599	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	0	4	theme	composite	77:85	arg1	behavior					12:19	Rheological behavior	0:19	Rheological behavior	0:19	Rheological behavior and particle alignment of cellulose nanocrystal and its composite hydrogels during 3D printing.
33278981	0	4	theme	composite	77:85	arg1	alignment					34:42	particle alignment	25:42	particle alignment	25:42	Rheological behavior and particle alignment of cellulose nanocrystal and its composite hydrogels during 3D printing.
33278981	7	5	dep	ratios	1054:1059	arg1	=					1087:1087	=	1087:1087	=	1087:1087	The results revealed that two hydrogels had favorable print fidelity at suitable ratios (CNC: HMP = 2:8, CNC: LMP = 10:5).
33278981	4	6	theme	wt	583:584	arg1	hydrogels					591:599	20 wt% CNC hydrogels	580:599	20 wt% CNC hydrogels	580:599	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	0	7	theme	3D	104:105	arg1	printing					107:114	3D printing	104:114	3D printing	104:114	Rheological behavior and particle alignment of cellulose nanocrystal and its composite hydrogels during 3D printing.
33278981	7	8	theme	=	1071:1071	arg1	2:8					1073:1075	HMP = 2:8	1067:1075	HMP = 2:8	1067:1075	The results revealed that two hydrogels had favorable print fidelity at suitable ratios (CNC: HMP = 2:8, CNC: LMP = 10:5).
33278981	1	9	from	potential	160:168	arg1	material					183:190	material	183:190	material	183:190	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	1	9	from	potential	160:168	arg1	food					197:200	food	197:200	food	197:200	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	1	9	from	potential	160:168	arg1	chemical					173:180	chemical	173:180	chemical	173:180	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	3	10	with	printability	402:413	arg1	%					472:472	0.5-25 wt%	463:472	0.5-25 wt%	463:472	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	3	10	with	printability	402:413	arg1	concentrations					447:460	different concentrations	437:460	different concentrations (0.5-25 wt%)	437:473	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	6	11	theme	composite	881:889	arg1	hydrogels					891:899	two composite hydrogels	877:899	two composite hydrogels for 3D printing	877:915	Furthermore, we prepared two composite hydrogels for 3D printing by blending CNC with high/low methoxy pectin (HMP/LMP).
33278981	4	12	theme	printing	723:730	arg1	direction					732:740	the printing direction	719:740	the printing direction	719:740	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	3	13	theme	self-assembly	509:521	arg1	behavior					523:530	the shear-induced self-assembly behavior	491:530	the shear-induced self-assembly behavior of CNC	491:537	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	7	14	contain	had	1013:1015	arg1	hydrogels					1003:1011	two hydrogels	999:1011	two hydrogels	999:1011	The results revealed that two hydrogels had favorable print fidelity at suitable ratios (CNC: HMP = 2:8, CNC: LMP = 10:5).
33278981	7	14	contain	had	1013:1015	arg2	fidelity					1033:1040	favorable print fidelity	1017:1040	favorable print fidelity	1017:1040	The results revealed that two hydrogels had favorable print fidelity at suitable ratios (CNC: HMP = 2:8, CNC: LMP = 10:5).
33278981	4	15	theme	CNC	587:589	arg1	hydrogels					591:599	20 wt% CNC hydrogels	580:599	20 wt% CNC hydrogels	580:599	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	8	16	theme	sustainable	1123:1133	arg1	choices					1135:1141	flexible and sustainable choices	1110:1141	flexible and sustainable choices for the development of medical tissue engineering	1110:1191	This provided flexible and sustainable choices for the development of medical tissue engineering.
33278981	4	17	theme	high	657:660	arg1	%					693:693	72 %-73 %	685:693	72 %-73 %	685:693	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	4	17	theme	high	657:660	arg1	degree					662:667	a high degree	655:667	a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction	655:740	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	0	18	theme	cellulose	47:55	arg1	nanocrystal					57:67	cellulose nanocrystal	47:67	cellulose nanocrystal	47:67	Rheological behavior and particle alignment of cellulose nanocrystal and its composite hydrogels during 3D printing.
33278981	1	19	contain	has	145:147	arg2	potential					160:168	tremendous potential	149:168	tremendous potential in chemical, material, and food fields	149:207	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	1	19	contain	has	145:147	arg1	CNC					140:142	CNC	140:142	CNC	140:142	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	1	19	contain	has	145:147	arg1	nanocrystal					127:137	Cellulose nanocrystal	117:137	Cellulose nanocrystal (CNC)	117:143	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	1	19	contain	has	145:147	arg2	bioresource					232:242	an attractive green bioresource	212:242	an attractive green bioresource	212:242	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	7	20	theme	HMP	1067:1069	arg1	2:8					1073:1075	HMP = 2:8	1067:1075	HMP = 2:8	1067:1075	The results revealed that two hydrogels had favorable print fidelity at suitable ratios (CNC: HMP = 2:8, CNC: LMP = 10:5).
33278981	2	21	theme	viscoelastic	259:270	arg1	hydrogels					272:280	viscoelastic hydrogels	259:280	viscoelastic hydrogels composed of anisotropic CNC using an extrusion-based 3D printing technology	259:356	We formulated viscoelastic hydrogels composed of anisotropic CNC using an extrusion-based 3D printing technology.
33278981	8	22	theme	medical	1166:1172	arg1	engineering					1181:1191	medical tissue engineering	1166:1191	medical tissue engineering	1166:1191	This provided flexible and sustainable choices for the development of medical tissue engineering.
33278981	8	23	theme	flexible	1110:1117	arg1	choices					1135:1141	flexible and sustainable choices	1110:1141	flexible and sustainable choices for the development of medical tissue engineering	1110:1191	This provided flexible and sustainable choices for the development of medical tissue engineering.
33278981	6	24	theme	high/low	938:945	arg1	HMP/LMP					963:969	HMP/LMP	963:969	HMP/LMP	963:969	Furthermore, we prepared two composite hydrogels for 3D printing by blending CNC with high/low methoxy pectin (HMP/LMP).
33278981	6	24	theme	high/low	938:945	arg1	pectin					955:960	high/low methoxy pectin	938:960	high/low methoxy pectin (HMP/LMP)	938:970	Furthermore, we prepared two composite hydrogels for 3D printing by blending CNC with high/low methoxy pectin (HMP/LMP).
33278981	7	25	dep	=	1087:1087	arg1	2:8					1073:1075	HMP = 2:8	1067:1075	HMP = 2:8	1067:1075	The results revealed that two hydrogels had favorable print fidelity at suitable ratios (CNC: HMP = 2:8, CNC: LMP = 10:5).
33278981	7	25	dep	=	1087:1087	arg1	CNC					1062:1064	CNC	1062:1064	CNC	1062:1064	The results revealed that two hydrogels had favorable print fidelity at suitable ratios (CNC: HMP = 2:8, CNC: LMP = 10:5).
33278981	7	25	dep	=	1087:1087	arg1	CNC					1078:1080	CNC	1078:1080	CNC	1078:1080	The results revealed that two hydrogels had favorable print fidelity at suitable ratios (CNC: HMP = 2:8, CNC: LMP = 10:5).
33278981	4	26	theme	alignment	703:711	arg1	%					693:693	72 %-73 %	685:693	72 %-73 %	685:693	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	4	26	theme	alignment	703:711	arg1	degree					662:667	a high degree	655:667	a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction	655:740	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	3	27	theme	different	437:445	arg1	%					472:472	0.5-25 wt%	463:472	0.5-25 wt%	463:472	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	3	27	theme	different	437:445	arg1	concentrations					447:460	different concentrations	437:460	different concentrations (0.5-25 wt%)	437:473	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	0	28	theme	Rheological	0:10	arg1	behavior					12:19	Rheological behavior	0:19	Rheological behavior	0:19	Rheological behavior and particle alignment of cellulose nanocrystal and its composite hydrogels during 3D printing.
33278981	8	29	theme	tissue	1174:1179	arg1	engineering					1181:1191	medical tissue engineering	1166:1191	medical tissue engineering	1166:1191	This provided flexible and sustainable choices for the development of medical tissue engineering.
33278981	3	30	with	properties	387:396	arg1	%					472:472	0.5-25 wt%	463:472	0.5-25 wt%	463:472	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	3	30	with	properties	387:396	arg1	concentrations					447:460	different concentrations	437:460	different concentrations (0.5-25 wt%)	437:473	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	8	31	theme	engineering	1181:1191	arg1	development					1151:1161	the development	1147:1161	the development of medical tissue engineering	1147:1191	This provided flexible and sustainable choices for the development of medical tissue engineering.
33278981	0	32	theme	particle	25:32	arg1	alignment					34:42	particle alignment	25:42	particle alignment	25:42	Rheological behavior and particle alignment of cellulose nanocrystal and its composite hydrogels during 3D printing.
33278981	7	33	theme	suitable	1045:1052	arg1	ratios					1054:1059	suitable ratios	1045:1059	suitable ratios (CNC: HMP = 2:8, CNC: LMP = 10:5)	1045:1093	The results revealed that two hydrogels had favorable print fidelity at suitable ratios (CNC: HMP = 2:8, CNC: LMP = 10:5).
33278981	5	34	theme	printable	805:813	arg1	materials					815:823	3D printable materials	802:823	3D printable materials with particle orientation	802:849	It provides quantitative guidelines for the development of 3D printable materials with particle orientation.
33278981	4	35	theme	CNC	699:701	arg1	alignment					703:711	CNC alignment	699:711	CNC alignment along the printing direction	699:740	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	6	36	theme	methoxy	947:953	arg1	HMP/LMP					963:969	HMP/LMP	963:969	HMP/LMP	963:969	Furthermore, we prepared two composite hydrogels for 3D printing by blending CNC with high/low methoxy pectin (HMP/LMP).
33278981	6	36	theme	methoxy	947:953	arg1	pectin					955:960	high/low methoxy pectin	938:960	high/low methoxy pectin (HMP/LMP)	938:970	Furthermore, we prepared two composite hydrogels for 3D printing by blending CNC with high/low methoxy pectin (HMP/LMP).
33278981	2	37	theme	anisotropic	294:304	arg1	CNC					306:308	anisotropic CNC	294:308	anisotropic CNC using an extrusion-based 3D printing technology	294:356	We formulated viscoelastic hydrogels composed of anisotropic CNC using an extrusion-based 3D printing technology.
33278981	5	38	theme	materials	815:823	arg1	development					787:797	the development	783:797	the development of 3D printable materials with particle orientation	783:849	It provides quantitative guidelines for the development of 3D printable materials with particle orientation.
33278981	3	39	theme	hydrogels	422:430	arg1	printability					402:413	printability	402:413	printability of CNC hydrogels with different concentrations (0.5-25 wt%)	402:473	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	3	39	theme	hydrogels	422:430	arg1	properties					387:396	the rheological properties	371:396	the rheological properties	371:396	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	3	40	theme	shear-induced	495:507	arg1	behavior					523:530	the shear-induced self-assembly behavior	491:530	the shear-induced self-assembly behavior of CNC	491:537	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	3	41	theme	wt	470:471	arg1	%					472:472	0.5-25 wt%	463:472	0.5-25 wt%	463:472	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	3	41	theme	wt	470:471	arg1	concentrations					447:460	different concentrations	437:460	different concentrations (0.5-25 wt%)	437:473	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	5	42	theme	quantitative	755:766	arg1	guidelines					768:777	quantitative guidelines	755:777	quantitative guidelines for the development of 3D printable materials with particle orientation	755:849	It provides quantitative guidelines for the development of 3D printable materials with particle orientation.
33278981	5	43	with	materials	815:823	arg1	orientation					839:849	particle orientation	830:849	particle orientation	830:849	It provides quantitative guidelines for the development of 3D printable materials with particle orientation.
33278981	3	44	theme	rheological	375:385	arg1	properties					387:396	the rheological properties	371:396	the rheological properties	371:396	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	5	45	theme	particle	830:837	arg1	orientation					839:849	particle orientation	830:849	particle orientation	830:849	It provides quantitative guidelines for the development of 3D printable materials with particle orientation.
33278981	0	46	theme	nanocrystal	57:67	arg1	behavior					12:19	Rheological behavior	0:19	Rheological behavior	0:19	Rheological behavior and particle alignment of cellulose nanocrystal and its composite hydrogels during 3D printing.
33278981	0	46	theme	nanocrystal	57:67	arg1	alignment					34:42	particle alignment	25:42	particle alignment	25:42	Rheological behavior and particle alignment of cellulose nanocrystal and its composite hydrogels during 3D printing.
33278981	7	47	theme	favorable	1017:1025	arg1	fidelity					1033:1040	favorable print fidelity	1017:1040	favorable print fidelity	1017:1040	The results revealed that two hydrogels had favorable print fidelity at suitable ratios (CNC: HMP = 2:8, CNC: LMP = 10:5).
33278981	1	48	theme	Cellulose	117:125	arg1	CNC					140:142	CNC	140:142	CNC	140:142	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	1	48	theme	Cellulose	117:125	arg1	nanocrystal					127:137	Cellulose nanocrystal	117:137	Cellulose nanocrystal (CNC)	117:143	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	3	49	theme	CNC	418:420	arg1	hydrogels					422:430	CNC hydrogels	418:430	CNC hydrogels	418:430	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	7	50	theme	print	1027:1031	arg1	fidelity					1033:1040	favorable print fidelity	1017:1040	favorable print fidelity	1017:1040	The results revealed that two hydrogels had favorable print fidelity at suitable ratios (CNC: HMP = 2:8, CNC: LMP = 10:5).
33278981	1	51	dep	chemical	173:180	arg1	fields					202:207	fields	202:207	fields	202:207	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	2	52	theme	printing	338:345	arg1	technology					347:356	an extrusion-based 3D printing technology	316:356	an extrusion-based 3D printing technology	316:356	We formulated viscoelastic hydrogels composed of anisotropic CNC using an extrusion-based 3D printing technology.
33278981	4	53	theme	orientation	672:682	arg1	%					693:693	72 %-73 %	685:693	72 %-73 %	685:693	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	4	53	theme	orientation	672:682	arg1	degree					662:667	a high degree	655:667	a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction	655:740	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	2	54	theme	3D	335:336	arg1	technology					347:356	an extrusion-based 3D printing technology	316:356	an extrusion-based 3D printing technology	316:356	We formulated viscoelastic hydrogels composed of anisotropic CNC using an extrusion-based 3D printing technology.
33278981	4	55	theme	optimal	611:617	arg1	resolution					625:634	optimal print resolution	611:634	optimal print resolution	611:634	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	5	56	theme	3D	802:803	arg1	materials					815:823	3D printable materials	802:823	3D printable materials with particle orientation	802:849	It provides quantitative guidelines for the development of 3D printable materials with particle orientation.
33278981	2	57	theme	extrusion-based	319:333	arg1	technology					347:356	an extrusion-based 3D printing technology	316:356	an extrusion-based 3D printing technology	316:356	We formulated viscoelastic hydrogels composed of anisotropic CNC using an extrusion-based 3D printing technology.
33278981	1	58	theme	attractive	215:224	arg1	bioresource					232:242	an attractive green bioresource	212:242	an attractive green bioresource	212:242	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	1	58	theme	attractive	215:224	arg1	potential					160:168	tremendous potential	149:168	tremendous potential in chemical, material, and food fields	149:207	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	4	59	theme	print	619:623	arg1	resolution					625:634	optimal print resolution	611:634	optimal print resolution	611:634	The results showed that 20 wt% CNC hydrogels exhibited optimal print resolution and fidelity, with a high degree of orientation (72 %-73 %) of CNC alignment along the printing direction.
33278981	3	60	theme	CNC	535:537	arg1	behavior					523:530	the shear-induced self-assembly behavior	491:530	the shear-induced self-assembly behavior of CNC	491:537	We explored the rheological properties and printability of CNC hydrogels with different concentrations (0.5-25 wt%), and quantified the shear-induced self-assembly behavior of CNC during printing.
33278981	1	61	theme	green	226:230	arg1	bioresource					232:242	an attractive green bioresource	212:242	an attractive green bioresource	212:242	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
33278981	1	61	theme	green	226:230	arg1	potential					160:168	tremendous potential	149:168	tremendous potential in chemical, material, and food fields	149:207	Cellulose nanocrystal (CNC) has tremendous potential in chemical, material, and food fields as an attractive green bioresource.
31900783	1	0	theme	aqueous	238:244	arg1	solution					246:253	aqueous solution	238:253	aqueous solution	238:253	The aim of this work was to prepare a composite material based on cocoa cortex and sodium alginate and test it to remove Cu(II) ions in aqueous solution in batch conditions.
31900783	9	1	theme	parameters	1169:1178	arg1	values					1141:1146	The values	1137:1146	The values of the thermodynamic parameters	1137:1178	The values of the thermodynamic parameters indicated that the process was spontaneous, with ΔG° values between (- 7.886 and - 9.458 kJ/mol) and endothermic, with ΔH° = 7.728 kJ/mol.
31900783	3	2	theme	initial	573:579	arg1	concentration					581:593	an initial concentration	570:593	an initial concentration of 100 mg/L	570:605	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	1	3	theme	sodium	185:190	arg1	alginate					192:199	sodium alginate	185:199	sodium alginate	185:199	The aim of this work was to prepare a composite material based on cocoa cortex and sodium alginate and test it to remove Cu(II) ions in aqueous solution in batch conditions.
31900783	4	4	theme	same	618:621	arg1	conditions					623:632	the same conditions	614:632	the same conditions	614:632	Under the same conditions, the cocoa cortex untreated exhibited extremely low adsorption, while when it was treated with hot soda, it adsorbed 13.67 mg/g.
31900783	3	5	dep	%	565:565	arg1	i.e.					554:557	i.e.	554:557	i.e.	554:557	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	6	6	theme	data	838:841	arg1	analysis					843:850	Kinetic data analysis	830:850	Kinetic data analysis	830:850	Kinetic data analysis suggested that the process was governed by adsorption (pseudo-second-order model) and diffusion through macropores and/or mesopores (intra-particle model).
31900783	1	7	theme	batch	258:262	arg1	conditions					264:273	batch conditions	258:273	batch conditions	258:273	The aim of this work was to prepare a composite material based on cocoa cortex and sodium alginate and test it to remove Cu(II) ions in aqueous solution in batch conditions.
31900783	6	8	theme	Kinetic	830:836	arg1	analysis					843:850	Kinetic data analysis	830:850	Kinetic data analysis	830:850	Kinetic data analysis suggested that the process was governed by adsorption (pseudo-second-order model) and diffusion through macropores and/or mesopores (intra-particle model).
31900783	2	9	theme	thermogravimetric	418:434	arg1	TGA/DTG					446:452	TGA/DTG	446:452	TGA/DTG	446:452	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	2	9	theme	thermogravimetric	418:434	arg1	analysis					436:443	thermogravimetric analysis	418:443	thermogravimetric analysis (TGA/DTG)	418:453	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	3	10	theme	concentration	581:593	arg1	%					565:565	95.32%	560:565	95.32% of an initial concentration of 100 mg/L	560:605	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	3	10	theme	concentration	581:593	arg1	concentration					581:593	an initial concentration	570:593	an initial concentration of 100 mg/L	570:605	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	9	11	with	spontaneous	1211:1221	arg1	values					1233:1238	ΔG° values	1229:1238	ΔG° values between (- 7.886 and - 9.458 kJ/mol) and endothermic	1229:1291	The values of the thermodynamic parameters indicated that the process was spontaneous, with ΔG° values between (- 7.886 and - 9.458 kJ/mol) and endothermic, with ΔH° = 7.728 kJ/mol.
31900783	9	11	with	spontaneous	1211:1221	arg1	ΔH° = 7.728 kJ/mol					1299:1316	ΔH° = 7.728 kJ/mol	1299:1316	ΔH° = 7.728 kJ/mol	1299:1316	The values of the thermodynamic parameters indicated that the process was spontaneous, with ΔG° values between (- 7.886 and - 9.458 kJ/mol) and endothermic, with ΔH° = 7.728 kJ/mol.
31900783	1	12	theme	work	118:121	arg1	aim					106:108	The aim	102:108	The aim of this work	102:121	The aim of this work was to prepare a composite material based on cocoa cortex and sodium alginate and test it to remove Cu(II) ions in aqueous solution in batch conditions.
31900783	0	13	theme	cocoa	68:72	arg1	cortex					74:79	cocoa cortex	68:79	cocoa cortex	68:79	Removal of Cu(II) from aqueous solution using a composite made from cocoa cortex and sodium alginate.
31900783	9	14	theme	thermodynamic	1155:1167	arg1	parameters					1169:1178	the thermodynamic parameters	1151:1178	the thermodynamic parameters	1151:1178	The values of the thermodynamic parameters indicated that the process was spontaneous, with ΔG° values between (- 7.886 and - 9.458 kJ/mol) and endothermic, with ΔH° = 7.728 kJ/mol.
31900783	8	15	theme	adsorption	1091:1100	arg1	76.92 mg/g					1125:1134	76.92 mg/g	1125:1134	76.92 mg/g	1125:1134	The maximum adsorption capacity of Cu(II) was 76.92 mg/g.
31900783	8	15	theme	adsorption	1091:1100	arg1	capacity					1102:1109	The maximum adsorption capacity	1079:1109	The maximum adsorption capacity of Cu(II)	1079:1119	The maximum adsorption capacity of Cu(II) was 76.92 mg/g.
31900783	3	16	theme	100 mg/L	598:605	arg1	concentration					581:593	an initial concentration	570:593	an initial concentration of 100 mg/L	570:605	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	8	17	theme	Cu	1114:1115	arg1	76.92 mg/g					1125:1134	76.92 mg/g	1125:1134	76.92 mg/g	1125:1134	The maximum adsorption capacity of Cu(II) was 76.92 mg/g.
31900783	8	17	theme	Cu	1114:1115	arg1	capacity					1102:1109	The maximum adsorption capacity	1079:1109	The maximum adsorption capacity of Cu(II)	1079:1119	The maximum adsorption capacity of Cu(II) was 76.92 mg/g.
31900783	6	18	theme	pseudo-second-order	907:925	arg1	adsorption					895:904	adsorption	895:904	adsorption (pseudo-second-order model)	895:932	Kinetic data analysis suggested that the process was governed by adsorption (pseudo-second-order model) and diffusion through macropores and/or mesopores (intra-particle model).
31900783	6	18	theme	pseudo-second-order	907:925	arg1	model					927:931	pseudo-second-order model	907:931	pseudo-second-order model	907:931	Kinetic data analysis suggested that the process was governed by adsorption (pseudo-second-order model) and diffusion through macropores and/or mesopores (intra-particle model).
31900783	10	19	dep	abstract	1329:1336	arg1	Graphical					1319:1327	Graphical	1319:1327	Graphical	1319:1327	Graphical abstract.
31900783	0	20	theme	sodium	85:90	arg1	alginate					92:99	sodium alginate	85:99	sodium alginate	85:99	Removal of Cu(II) from aqueous solution using a composite made from cocoa cortex and sodium alginate.
31900783	2	21	theme	scanning	334:341	arg1	SEM					364:366	SEM	364:366	SEM	364:366	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	2	21	theme	scanning	334:341	arg1	microscopy					352:361	scanning electron microscopy	334:361	scanning electron microscopy (SEM)	334:367	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	2	22	theme	electron	343:350	arg1	SEM					364:366	SEM	364:366	SEM	364:366	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	2	22	theme	electron	343:350	arg1	microscopy					352:361	scanning electron microscopy	334:361	scanning electron microscopy (SEM)	334:367	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	1	23	theme	composite	140:148	arg1	material					150:157	a composite material	138:157	a composite material based on cocoa cortex and sodium alginate	138:199	The aim of this work was to prepare a composite material based on cocoa cortex and sodium alginate and test it to remove Cu(II) ions in aqueous solution in batch conditions.
31900783	2	24	theme	infrared	388:395	arg1	FTIR					411:414	FTIR	411:414	FTIR	411:414	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	2	24	theme	infrared	388:395	arg1	spectroscopy					397:408	Fourier-transform infrared spectroscopy	370:408	Fourier-transform infrared spectroscopy (FTIR)	370:415	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	1	25	theme	Cu	223:224	arg1	ions					230:233	Cu(II) ions	223:233	Cu(II) ions	223:233	The aim of this work was to prepare a composite material based on cocoa cortex and sodium alginate and test it to remove Cu(II) ions in aqueous solution in batch conditions.
31900783	3	26	theme	highest	486:492	arg1	19.54 mg/g					542:551	19.54 mg/g	542:551	19.54 mg/g	542:551	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	3	26	theme	highest	486:492	arg1	II					516:517	II	516:517	II	516:517	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	3	26	theme	highest	486:492	arg1	amount					494:499	The highest amount	482:499	The highest amount of adsorbed Cu(II) for the composite	482:536	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	3	26	theme	highest	486:492	arg1	Cu					513:514	adsorbed Cu	504:514	adsorbed Cu(II)	504:518	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	2	27	theme	Fourier-transform	370:386	arg1	FTIR					411:414	FTIR	411:414	FTIR	411:414	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	2	27	theme	Fourier-transform	370:386	arg1	spectroscopy					397:408	Fourier-transform infrared spectroscopy	370:408	Fourier-transform infrared spectroscopy (FTIR)	370:415	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	7	28	theme	adsorption	1012:1021	arg1	Langmuir					1067:1074	Langmuir's	1067:1076	Langmuir's	1067:1076	The adsorption isotherm that best described the system was Langmuir's.
31900783	7	28	theme	adsorption	1012:1021	arg1	isotherm					1023:1030	The adsorption isotherm	1008:1030	The adsorption isotherm that best described the system	1008:1061	The adsorption isotherm that best described the system was Langmuir's.
31900783	2	29	theme	elemental	314:322	arg1	analysis					324:331	elemental analysis	314:331	elemental analysis	314:331	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	0	30	theme	aqueous	23:29	arg1	solution					31:38	aqueous solution	23:38	aqueous solution	23:38	Removal of Cu(II) from aqueous solution using a composite made from cocoa cortex and sodium alginate.
31900783	2	31	theme	charge	474:479	arg1	analysis					436:443	thermogravimetric analysis	418:443	thermogravimetric analysis (TGA/DTG)	418:453	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	2	31	theme	charge	474:479	arg1	microscopy					352:361	scanning electron microscopy	334:361	scanning electron microscopy (SEM)	334:367	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	2	31	theme	charge	474:479	arg1	point					460:464	point	460:464	point of zero charge	460:479	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	2	31	theme	charge	474:479	arg1	spectroscopy					397:408	Fourier-transform infrared spectroscopy	370:408	Fourier-transform infrared spectroscopy (FTIR)	370:415	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	2	31	theme	charge	474:479	arg1	SEM					364:366	SEM	364:366	SEM	364:366	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	2	31	theme	charge	474:479	arg1	FTIR					411:414	FTIR	411:414	FTIR	411:414	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	2	31	theme	charge	474:479	arg1	analysis					324:331	elemental analysis	314:331	elemental analysis	314:331	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	2	31	theme	charge	474:479	arg1	TGA/DTG					446:452	TGA/DTG	446:452	TGA/DTG	446:452	The composite was characterized using elemental analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA/DTG), and point of zero charge.
31900783	0	32	from	solution	31:38	arg1	Removal					0:6	Removal	0:6	Removal of Cu(II) from aqueous solution	0:38	Removal of Cu(II) from aqueous solution using a composite made from cocoa cortex and sodium alginate.
31900783	4	33	theme	low	682:684	arg1	adsorption					686:695	extremely low adsorption	672:695	extremely low adsorption	672:695	Under the same conditions, the cocoa cortex untreated exhibited extremely low adsorption, while when it was treated with hot soda, it adsorbed 13.67 mg/g.
31900783	6	34	theme	intra-particle	985:998	arg1	macropores					956:965	macropores	956:965	macropores	956:965	Kinetic data analysis suggested that the process was governed by adsorption (pseudo-second-order model) and diffusion through macropores and/or mesopores (intra-particle model).
31900783	6	34	theme	intra-particle	985:998	arg1	model					1000:1004	intra-particle model	985:1004	intra-particle model	985:1004	Kinetic data analysis suggested that the process was governed by adsorption (pseudo-second-order model) and diffusion through macropores and/or mesopores (intra-particle model).
31900783	3	35	theme	adsorbed	504:511	arg1	II					516:517	II	516:517	II	516:517	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	3	35	theme	adsorbed	504:511	arg1	Cu					513:514	adsorbed Cu	504:514	adsorbed Cu(II)	504:518	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	3	36	theme	Cu	513:514	arg1	19.54 mg/g					542:551	19.54 mg/g	542:551	19.54 mg/g	542:551	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	3	36	theme	Cu	513:514	arg1	II					516:517	II	516:517	II	516:517	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	3	36	theme	Cu	513:514	arg1	amount					494:499	The highest amount	482:499	The highest amount of adsorbed Cu(II) for the composite	482:536	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	3	36	theme	Cu	513:514	arg1	Cu					513:514	adsorbed Cu	504:514	adsorbed Cu(II)	504:518	The highest amount of adsorbed Cu(II) for the composite was 19.54 mg/g, i.e., 95.32% of an initial concentration of 100 mg/L.
31900783	9	37	theme	ΔG°	1229:1231	arg1	values					1233:1238	ΔG° values	1229:1238	ΔG° values between (- 7.886 and - 9.458 kJ/mol) and endothermic	1229:1291	The values of the thermodynamic parameters indicated that the process was spontaneous, with ΔG° values between (- 7.886 and - 9.458 kJ/mol) and endothermic, with ΔH° = 7.728 kJ/mol.
31900783	9	38	dep	- 7.886	1249:1255	arg1	endothermic					1281:1291	endothermic	1281:1291	endothermic	1281:1291	The values of the thermodynamic parameters indicated that the process was spontaneous, with ΔG° values between (- 7.886 and - 9.458 kJ/mol) and endothermic, with ΔH° = 7.728 kJ/mol.
31900783	1	39	theme	cocoa	168:172	arg1	cortex					174:179	cocoa cortex	168:179	cocoa cortex	168:179	The aim of this work was to prepare a composite material based on cocoa cortex and sodium alginate and test it to remove Cu(II) ions in aqueous solution in batch conditions.
31900783	4	40	theme	untreated	652:660	arg1	cocoa					639:643	the cocoa	635:643	the cocoa cortex untreated	635:660	Under the same conditions, the cocoa cortex untreated exhibited extremely low adsorption, while when it was treated with hot soda, it adsorbed 13.67 mg/g.
31900783	8	41	theme	maximum	1083:1089	arg1	76.92 mg/g					1125:1134	76.92 mg/g	1125:1134	76.92 mg/g	1125:1134	The maximum adsorption capacity of Cu(II) was 76.92 mg/g.
31900783	8	41	theme	maximum	1083:1089	arg1	capacity					1102:1109	The maximum adsorption capacity	1079:1109	The maximum adsorption capacity of Cu(II)	1079:1119	The maximum adsorption capacity of Cu(II) was 76.92 mg/g.
31900783	0	42	theme	Cu	11:12	arg1	Removal					0:6	Removal	0:6	Removal of Cu(II) from aqueous solution	0:38	Removal of Cu(II) from aqueous solution using a composite made from cocoa cortex and sodium alginate.
34443315	5	0	theme	X-ray	745:749	arg1	diffraction					751:761	X-ray diffraction	745:761	X-ray diffraction	745:761	The fibers were characterized by microscopy, infrared spectroscopy, thermogravimetric analysis and X-ray diffraction after each step of the process to understand the evolution of their morphology and composition.
34443315	1	1	theme	short	147:151	arg1	fibers					158:163	short bast fibers	147:163	short bast fibers	147:163	Nanocellulose was extracted from short bast fibers, from hemp (Cannabis sativa L.) plants harvested at seed maturity, non-retted, and mechanically decorticated in a defibering apparatus, giving non-aligned fibers.
34443315	0	2	theme	Byproducts	16:25	arg1	Valorization					0:11	Valorization	0:11	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.	0:112	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.
34443315	1	3	theme	seed	217:220	arg1	maturity					222:229	seed maturity	217:229	seed maturity	217:229	Nanocellulose was extracted from short bast fibers, from hemp (Cannabis sativa L.) plants harvested at seed maturity, non-retted, and mechanically decorticated in a defibering apparatus, giving non-aligned fibers.
34443315	0	4	theme	Bast	72:75	arg1	Fibers					77:82	Short Non-Aligned Bast Fibers	54:82	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.	0:112	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.
34443315	1	5	theme	non-aligned	308:318	arg1	fibers					320:325	non-aligned fibers	308:325	non-aligned fibers	308:325	Nanocellulose was extracted from short bast fibers, from hemp (Cannabis sativa L.) plants harvested at seed maturity, non-retted, and mechanically decorticated in a defibering apparatus, giving non-aligned fibers.
34443315	8	6	theme	yellowish	1160:1168	arg1	color					1170:1174	a yellowish color	1158:1174	a yellowish color	1158:1174	The nanocellulose retained a yellowish color, indicating the presence of some residual lignin.
34443315	1	7	theme	bast	153:156	arg1	fibers					158:163	short bast fibers	147:163	short bast fibers	147:163	Nanocellulose was extracted from short bast fibers, from hemp (Cannabis sativa L.) plants harvested at seed maturity, non-retted, and mechanically decorticated in a defibering apparatus, giving non-aligned fibers.
34443315	9	8	theme	rod-like	1363:1370	arg1	nanofibrils					1372:1382	wood pulp-derived rod-like nanofibrils	1345:1382	wood pulp-derived rod-like nanofibrils	1345:1382	The properties of the nanopaper prepared with the hemp nanocellulose were similar to those of nanopapers prepared with wood pulp-derived rod-like nanofibrils.
34443315	5	9	theme	infrared	691:698	arg1	spectroscopy					700:711	infrared spectroscopy	691:711	infrared spectroscopy	691:711	The fibers were characterized by microscopy, infrared spectroscopy, thermogravimetric analysis and X-ray diffraction after each step of the process to understand the evolution of their morphology and composition.
34443315	6	10	theme	nanofibrils	965:975	arg1	widths					936:941	widths	936:941	widths of 5-12 nm	936:952	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	6	10	theme	nanofibrils	965:975	arg1	fibers					1019:1024	some larger fibers	1007:1024	some larger fibers	1007:1024	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	6	10	theme	nanofibrils	965:975	arg1	stacks					955:960	stacks	955:960	stacks of nanofibrils with widths of 20-200 nm	955:1000	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	9	11	link	pulp-derived	1350:1361	arg1	nanofibrils					1372:1382	wood pulp-derived rod-like nanofibrils	1345:1382	wood pulp-derived rod-like nanofibrils	1345:1382	The properties of the nanopaper prepared with the hemp nanocellulose were similar to those of nanopapers prepared with wood pulp-derived rod-like nanofibrils.
34443315	5	12	theme	morphology	831:840	arg1	evolution					812:820	the evolution	808:820	the evolution of their morphology and composition	808:856	The fibers were characterized by microscopy, infrared spectroscopy, thermogravimetric analysis and X-ray diffraction after each step of the process to understand the evolution of their morphology and composition.
34443315	6	13	theme	nanocellulose	872:884	arg1	suspension					886:895	The obtained nanocellulose suspension	859:895	The obtained nanocellulose suspension	859:895	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	4	14	theme	ultrafine	618:626	arg1	grinder					637:643	an ultrafine friction grinder	615:643	an ultrafine friction grinder	615:643	The chemically pretreated fibers were then refined in a beater and treated with a cellulase enzyme, followed by mechanical defibrillation in an ultrafine friction grinder.
34443315	5	15	theme	thermogravimetric	714:730	arg1	analysis					732:739	thermogravimetric analysis	714:739	thermogravimetric analysis	714:739	The fibers were characterized by microscopy, infrared spectroscopy, thermogravimetric analysis and X-ray diffraction after each step of the process to understand the evolution of their morphology and composition.
34443315	6	16	theme	obtained	863:870	arg1	suspension					886:895	The obtained nanocellulose suspension	859:895	The obtained nanocellulose suspension	859:895	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	2	17	theme	fibers	438:443	arg1	components					420:429	the non-cellulosic components	401:429	the non-cellulosic components of the fibers	401:443	A chemical pretreatment with NaOH and HCl allowed the removal of most of the non-cellulosic components of the fibers.
34443315	6	18	theme	nm	999:1000	arg1	widths					982:987	widths	982:987	widths of 20-200 nm	982:1000	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	2	19	theme	non-cellulosic	405:418	arg1	components					420:429	the non-cellulosic components	401:429	the non-cellulosic components of the fibers	401:443	A chemical pretreatment with NaOH and HCl allowed the removal of most of the non-cellulosic components of the fibers.
34443315	9	20	theme	nanopaper	1248:1256	arg1	properties					1230:1239	The properties	1226:1239	The properties of the nanopaper prepared with the hemp nanocellulose	1226:1293	The properties of the nanopaper prepared with the hemp nanocellulose were similar to those of nanopapers prepared with wood pulp-derived rod-like nanofibrils.
34443315	9	20	theme	nanopaper	1248:1256	arg1	similar					1300:1306	similar	1300:1306	similar	1300:1306	The properties of the nanopaper prepared with the hemp nanocellulose were similar to those of nanopapers prepared with wood pulp-derived rod-like nanofibrils.
34443315	5	21	theme	composition	846:856	arg1	evolution					812:820	the evolution	808:820	the evolution of their morphology and composition	808:856	The fibers were characterized by microscopy, infrared spectroscopy, thermogravimetric analysis and X-ray diffraction after each step of the process to understand the evolution of their morphology and composition.
34443315	5	22	theme	process	786:792	arg1	step					774:777	each step	769:777	each step of the process to understand the evolution of their morphology and composition	769:856	The fibers were characterized by microscopy, infrared spectroscopy, thermogravimetric analysis and X-ray diffraction after each step of the process to understand the evolution of their morphology and composition.
34443315	6	23	with	nanofibrils	919:929	arg1	widths					936:941	widths	936:941	widths of 5-12 nm	936:952	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	6	23	with	nanofibrils	919:929	arg1	fibers					1019:1024	some larger fibers	1007:1024	some larger fibers	1007:1024	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	6	23	with	nanofibrils	919:929	arg1	stacks					955:960	stacks	955:960	stacks of nanofibrils with widths of 20-200 nm	955:1000	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	1	24	theme	hemp	171:174	arg1	plants					197:202	hemp (Cannabis sativa L.) plants	171:202	hemp (Cannabis sativa L.) plants harvested at seed maturity	171:229	Nanocellulose was extracted from short bast fibers, from hemp (Cannabis sativa L.) plants harvested at seed maturity, non-retted, and mechanically decorticated in a defibering apparatus, giving non-aligned fibers.
34443315	9	25	theme	hemp	1276:1279	arg1	nanocellulose					1281:1293	the hemp nanocellulose	1272:1293	the hemp nanocellulose	1272:1293	The properties of the nanopaper prepared with the hemp nanocellulose were similar to those of nanopapers prepared with wood pulp-derived rod-like nanofibrils.
34443315	7	26	theme	crystallinity	1031:1043	arg1	index					1045:1049	The crystallinity index	1027:1049	The crystallinity index	1027:1049	The crystallinity index was found to increase from 74% for the raw fibers to 80% for the nanocellulose.
34443315	4	27	from	defibrillation	597:610	arg1	grinder					637:643	an ultrafine friction grinder	615:643	an ultrafine friction grinder	615:643	The chemically pretreated fibers were then refined in a beater and treated with a cellulase enzyme, followed by mechanical defibrillation in an ultrafine friction grinder.
34443315	4	28	theme	mechanical	586:595	arg1	defibrillation					597:610	mechanical defibrillation	586:610	mechanical defibrillation in an ultrafine friction grinder	586:643	The chemically pretreated fibers were then refined in a beater and treated with a cellulase enzyme, followed by mechanical defibrillation in an ultrafine friction grinder.
34443315	2	29	theme	most	393:396	arg1	removal					382:388	the removal	378:388	the removal of most of the non-cellulosic components of the fibers	378:443	A chemical pretreatment with NaOH and HCl allowed the removal of most of the non-cellulosic components of the fibers.
34443315	6	30	theme	nm	951:952	arg1	widths					936:941	widths	936:941	widths of 5-12 nm	936:952	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	6	30	theme	nm	951:952	arg1	fibers					1019:1024	some larger fibers	1007:1024	some larger fibers	1007:1024	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	6	30	theme	nm	951:952	arg1	stacks					955:960	stacks	955:960	stacks of nanofibrils with widths of 20-200 nm	955:1000	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	0	31	theme	Nanocellulose	99:111	arg1	Source					89:94	a Source	87:94	a Source of Nanocellulose	87:111	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.
34443315	6	32	theme	larger	1012:1017	arg1	fibers					1019:1024	some larger fibers	1007:1024	some larger fibers	1007:1024	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	0	33	theme	Multipurpose	35:46	arg1	Crop					48:51	Hemp Multipurpose Crop	30:51	Hemp Multipurpose Crop	30:51	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.
34443315	8	34	theme	lignin	1218:1223	arg1	presence					1192:1199	the presence	1188:1199	the presence of some residual lignin	1188:1223	The nanocellulose retained a yellowish color, indicating the presence of some residual lignin.
34443315	4	35	theme	friction	628:635	arg1	grinder					637:643	an ultrafine friction grinder	615:643	an ultrafine friction grinder	615:643	The chemically pretreated fibers were then refined in a beater and treated with a cellulase enzyme, followed by mechanical defibrillation in an ultrafine friction grinder.
34443315	1	36	theme	sativa	186:191	arg1	Cannabis					177:184	Cannabis sativa L.	177:194	Cannabis sativa L.	177:194	Nanocellulose was extracted from short bast fibers, from hemp (Cannabis sativa L.) plants harvested at seed maturity, non-retted, and mechanically decorticated in a defibering apparatus, giving non-aligned fibers.
34443315	1	36	theme	sativa	186:191	arg1	hemp					171:174	hemp	171:174	hemp (Cannabis sativa L.) plants harvested at seed maturity	171:229	Nanocellulose was extracted from short bast fibers, from hemp (Cannabis sativa L.) plants harvested at seed maturity, non-retted, and mechanically decorticated in a defibering apparatus, giving non-aligned fibers.
34443315	0	37	theme	Hemp	30:33	arg1	Crop					48:51	Hemp Multipurpose Crop	30:51	Hemp Multipurpose Crop	30:51	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.
34443315	9	38	theme	pulp-derived	1350:1361	arg1	nanofibrils					1372:1382	wood pulp-derived rod-like nanofibrils	1345:1382	wood pulp-derived rod-like nanofibrils	1345:1382	The properties of the nanopaper prepared with the hemp nanocellulose were similar to those of nanopapers prepared with wood pulp-derived rod-like nanofibrils.
34443315	8	39	theme	residual	1209:1216	arg1	lignin					1218:1223	some residual lignin	1204:1223	some residual lignin	1204:1223	The nanocellulose retained a yellowish color, indicating the presence of some residual lignin.
34443315	4	40	theme	pretreated	489:498	arg1	fibers					500:505	The chemically pretreated fibers	474:505	The chemically pretreated fibers	474:505	The chemically pretreated fibers were then refined in a beater and treated with a cellulase enzyme, followed by mechanical defibrillation in an ultrafine friction grinder.
34443315	0	41	theme	Crop	48:51	arg1	Byproducts					16:25	Byproducts	16:25	Byproducts of Hemp Multipurpose Crop	16:51	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.
34443315	1	42	theme	defibering	279:288	arg1	apparatus					290:298	a defibering apparatus	277:298	a defibering apparatus	277:298	Nanocellulose was extracted from short bast fibers, from hemp (Cannabis sativa L.) plants harvested at seed maturity, non-retted, and mechanically decorticated in a defibering apparatus, giving non-aligned fibers.
34443315	1	43	dep	Cannabis	177:184	arg1	L.					193:194	Cannabis sativa L.	177:194	Cannabis sativa L.	177:194	Nanocellulose was extracted from short bast fibers, from hemp (Cannabis sativa L.) plants harvested at seed maturity, non-retted, and mechanically decorticated in a defibering apparatus, giving non-aligned fibers.
34443315	7	44	theme	raw	1090:1092	arg1	fibers					1094:1099	the raw fibers	1086:1099	the raw fibers	1086:1099	The crystallinity index was found to increase from 74% for the raw fibers to 80% for the nanocellulose.
34443315	6	45	with	nanofibrils	965:975	arg1	widths					982:987	widths	982:987	widths of 20-200 nm	982:1000	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	2	46	with	pretreatment	339:350	arg1	HCl					366:368	HCl	366:368	HCl	366:368	A chemical pretreatment with NaOH and HCl allowed the removal of most of the non-cellulosic components of the fibers.
34443315	2	46	with	pretreatment	339:350	arg1	NaOH					357:360	NaOH	357:360	NaOH	357:360	A chemical pretreatment with NaOH and HCl allowed the removal of most of the non-cellulosic components of the fibers.
34443315	4	47	theme	cellulase	556:564	arg1	enzyme					566:571	a cellulase enzyme	554:571	a cellulase enzyme	554:571	The chemically pretreated fibers were then refined in a beater and treated with a cellulase enzyme, followed by mechanical defibrillation in an ultrafine friction grinder.
34443315	0	48	theme	Non-Aligned	60:70	arg1	Fibers					77:82	Short Non-Aligned Bast Fibers	54:82	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.	0:112	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.
34443315	0	49	theme	Short	54:58	arg1	Fibers					77:82	Short Non-Aligned Bast Fibers	54:82	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.	0:112	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.
34443315	6	50	theme	short	913:917	arg1	nanofibrils					919:929	short nanofibrils	913:929	short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers	913:1024	The obtained nanocellulose suspension was composed of short nanofibrils with widths of 5-12 nm, stacks of nanofibrils with widths of 20-200 nm, and some larger fibers.
34443315	0	51	dep	Valorization	0:11	arg1	Fibers					77:82	Short Non-Aligned Bast Fibers	54:82	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.	0:112	Valorization of Byproducts of Hemp Multipurpose Crop: Short Non-Aligned Bast Fibers as a Source of Nanocellulose.
34443315	2	52	theme	chemical	330:337	arg1	pretreatment					339:350	A chemical pretreatment	328:350	A chemical pretreatment with NaOH and HCl	328:368	A chemical pretreatment with NaOH and HCl allowed the removal of most of the non-cellulosic components of the fibers.
34443315	9	53	theme	wood	1345:1348	arg1	nanofibrils					1372:1382	wood pulp-derived rod-like nanofibrils	1345:1382	wood pulp-derived rod-like nanofibrils	1345:1382	The properties of the nanopaper prepared with the hemp nanocellulose were similar to those of nanopapers prepared with wood pulp-derived rod-like nanofibrils.
34198162	0	0	theme	organoids	100:108	arg1	matrix					83:88	the extracellular matrix	65:88	the extracellular matrix of kidney organoids	65:108	Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition.
34198162	4	1	theme	excessive	702:710	arg1	accumulation					712:723	Such an excessive accumulation	694:723	Such an excessive accumulation of specific collagen types	694:750	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	4	1	theme	excessive	702:710	arg1	hallmark					757:764	a hallmark	755:764	a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney	755:886	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	8	2	theme	abnormal	1475:1482	arg1	expression					1502:1511	abnormal type 1a1 collagen expression	1475:1511	abnormal type 1a1 collagen expression	1475:1511	Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application.
34198162	1	3	theme	kidney	275:280	arg1	diseases					282:289	kidney diseases	275:289	kidney diseases	275:289	Differentiated kidney organoids from induced pluripotent stem cells hold promise as a treatment for patients with kidney diseases.
34198162	0	4	theme	kidney	93:98	arg1	organoids					100:108	kidney organoids	93:108	kidney organoids	93:108	Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition.
34198162	8	5	theme	closer	1539:1544	arg1	organoids					1529:1537	kidney organoids	1522:1537	kidney organoids closer to clinical application	1522:1568	Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application.
34198162	2	6	theme	cellular	377:384	arg1	compositions					404:415	their cellular and extracellular compositions	371:415	their cellular and extracellular compositions	371:415	Before these organoids can be translated to the clinic, shortcomings regarding their cellular and extracellular compositions, and their developmental plateau need to be overcome.
34198162	5	7	theme	air-liquid	1088:1097	arg1	interface					1099:1107	an air-liquid interface	1085:1107	an air-liquid interface	1085:1107	Here we hypothesized the need for a three-dimensional environment to grow the kidney organoids, which could better mimic the in vivo surroundings of the developing kidney than standard culture on an air-liquid interface.
34198162	8	8	theme	kidney	1423:1428	arg1	culture					1439:1445	a prolonged kidney organoid culture	1411:1445	a prolonged kidney organoid culture in vitro	1411:1454	Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application.
34198162	4	9	theme	life-threatening	798:813	arg1	condition					828:836	a life-threatening pathological condition	796:836	a life-threatening pathological condition	796:836	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	5	10	theme	kidney	1053:1058	arg1	surroundings					1022:1033	the in vivo surroundings	1010:1033	the in vivo surroundings of the developing kidney than standard culture	1010:1080	Here we hypothesized the need for a three-dimensional environment to grow the kidney organoids, which could better mimic the in vivo surroundings of the developing kidney than standard culture on an air-liquid interface.
34198162	6	11	theme	type	1222:1225	arg1	collagen					1231:1238	type 1a1 collagen	1222:1238	decreased type 1a1 collagen expression	1212:1249	Encapsulating organoids for four days in a soft, thiol-ene cross-linked alginate hydrogel resulted in decreased type 1a1 collagen expression.
34198162	6	12	theme	thiol-ene	1159:1167	arg1	hydrogel					1191:1198	a soft, thiol-ene cross-linked alginate hydrogel	1151:1198	hydrogel	1191:1198	Encapsulating organoids for four days in a soft, thiol-ene cross-linked alginate hydrogel resulted in decreased type 1a1 collagen expression.
34198162	5	13	theme	kidney	967:972	arg1	organoids					974:982	the kidney organoids	963:982	the kidney organoids	963:982	Here we hypothesized the need for a three-dimensional environment to grow the kidney organoids, which could better mimic the in vivo surroundings of the developing kidney than standard culture on an air-liquid interface.
34198162	6	14	theme	decreased	1212:1220	arg1	expression					1240:1249	decreased type 1a1 collagen expression	1212:1249	decreased type 1a1 collagen expression	1212:1249	Encapsulating organoids for four days in a soft, thiol-ene cross-linked alginate hydrogel resulted in decreased type 1a1 collagen expression.
34198162	0	15	link	cross-linked	10:21	arg1	encapsulation					41:53	Thiol-ene cross-linked alginate hydrogel encapsulation	0:53	Thiol-ene cross-linked alginate hydrogel encapsulation	0:53	Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition.
34198162	4	16	theme	fibrosis	775:782	arg1	accumulation					712:723	Such an excessive accumulation	694:723	Such an excessive accumulation of specific collagen types	694:750	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	4	16	theme	fibrosis	775:782	arg1	hallmark					757:764	a hallmark	755:764	a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney	755:886	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	4	17	theme	types	746:750	arg1	accumulation					712:723	Such an excessive accumulation	694:723	Such an excessive accumulation of specific collagen types	694:750	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	4	17	theme	types	746:750	arg1	hallmark					757:764	a hallmark	755:764	a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney	755:886	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	0	18	theme	type	131:134	arg1	deposition					149:158	abnormal type 1a1 collagen deposition	122:158	abnormal type 1a1 collagen deposition	122:158	Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition.
34198162	4	19	theme	human	875:879	arg1	kidney					881:886	the human kidney	871:886	the human kidney	871:886	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	8	20	theme	kidney	1522:1527	arg1	organoids					1529:1537	kidney organoids	1522:1537	kidney organoids closer to clinical application	1522:1568	Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application.
34198162	1	21	theme	induced	198:204	arg1	cells					223:227	induced pluripotent stem cells	198:227	induced pluripotent stem cells	198:227	Differentiated kidney organoids from induced pluripotent stem cells hold promise as a treatment for patients with kidney diseases.
34198162	0	22	theme	abnormal	122:129	arg1	deposition					149:158	abnormal type 1a1 collagen deposition	122:158	abnormal type 1a1 collagen deposition	122:158	Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition.
34198162	5	23	theme	three-dimensional	925:941	arg1	environment					943:953	a three-dimensional environment	923:953	a three-dimensional environment	923:953	Here we hypothesized the need for a three-dimensional environment to grow the kidney organoids, which could better mimic the in vivo surroundings of the developing kidney than standard culture on an air-liquid interface.
34198162	6	24	link	cross-linked	1169:1180	arg1	hydrogel					1191:1198	a soft, thiol-ene cross-linked alginate hydrogel	1151:1198	hydrogel	1191:1198	Encapsulating organoids for four days in a soft, thiol-ene cross-linked alginate hydrogel resulted in decreased type 1a1 collagen expression.
34198162	6	25	theme	cross-linked	1169:1180	arg1	hydrogel					1191:1198	a soft, thiol-ene cross-linked alginate hydrogel	1151:1198	hydrogel	1191:1198	Encapsulating organoids for four days in a soft, thiol-ene cross-linked alginate hydrogel resulted in decreased type 1a1 collagen expression.
34198162	1	26	theme	pluripotent	206:216	arg1	cells					223:227	induced pluripotent stem cells	198:227	induced pluripotent stem cells	198:227	Differentiated kidney organoids from induced pluripotent stem cells hold promise as a treatment for patients with kidney diseases.
34198162	0	27	theme	cross-linked	10:21	arg1	encapsulation					41:53	Thiol-ene cross-linked alginate hydrogel encapsulation	0:53	Thiol-ene cross-linked alginate hydrogel encapsulation	0:53	Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition.
34198162	4	28	theme	renal	769:773	arg1	fibrosis					775:782	renal fibrosis	769:782	renal fibrosis	769:782	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	1	29	theme	stem	218:221	arg1	cells					223:227	induced pluripotent stem cells	198:227	induced pluripotent stem cells	198:227	Differentiated kidney organoids from induced pluripotent stem cells hold promise as a treatment for patients with kidney diseases.
34198162	0	30	theme	Thiol-ene	0:8	arg1	encapsulation					41:53	Thiol-ene cross-linked alginate hydrogel encapsulation	0:53	Thiol-ene cross-linked alginate hydrogel encapsulation	0:53	Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition.
34198162	4	31	theme	kidney	881:886	arg1	functions					858:866	key functions	854:866	key functions of the human kidney	854:886	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	6	32	theme	alginate	1182:1189	arg1	hydrogel					1191:1198	a soft, thiol-ene cross-linked alginate hydrogel	1151:1198	hydrogel	1191:1198	Encapsulating organoids for four days in a soft, thiol-ene cross-linked alginate hydrogel resulted in decreased type 1a1 collagen expression.
34198162	8	33	theme	type	1484:1487	arg1	expression					1502:1511	abnormal type 1a1 collagen expression	1475:1511	abnormal type 1a1 collagen expression	1475:1511	Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application.
34198162	0	34	theme	hydrogel	32:39	arg1	encapsulation					41:53	Thiol-ene cross-linked alginate hydrogel encapsulation	0:53	Thiol-ene cross-linked alginate hydrogel encapsulation	0:53	Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition.
34198162	6	35	theme	collagen	1231:1238	arg1	expression					1240:1249	decreased type 1a1 collagen expression	1212:1249	decreased type 1a1 collagen expression	1212:1249	Encapsulating organoids for four days in a soft, thiol-ene cross-linked alginate hydrogel resulted in decreased type 1a1 collagen expression.
34198162	0	36	theme	collagen	140:147	arg1	deposition					149:158	abnormal type 1a1 collagen deposition	122:158	abnormal type 1a1 collagen deposition	122:158	Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition.
34198162	3	37	theme	specific	578:585	arg1	change					587:592	a specific change	576:592	a specific change in the extracellular matrix composition	576:632	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	0	38	theme	alginate	23:30	arg1	encapsulation					41:53	Thiol-ene cross-linked alginate hydrogel encapsulation	0:53	Thiol-ene cross-linked alginate hydrogel encapsulation	0:53	Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition.
34198162	0	39	theme	1a1	136:138	arg1	deposition					149:158	abnormal type 1a1 collagen deposition	122:158	abnormal type 1a1 collagen deposition	122:158	Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition.
34198162	3	40	theme	2	674:674	arg1	expression					649:658	increased expression	639:658	increased expression of types 1a1, 2 and 6a1 collagen	639:691	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	3	41	theme	prolonged	540:548	arg1	time					558:561	a prolonged culture time	538:561	a prolonged culture time	538:561	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	3	42	theme	culture	550:556	arg1	time					558:561	a prolonged culture time	538:561	a prolonged culture time	538:561	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	7	43	theme	morphology	1336:1345	arg1	changes					1305:1311	any changes	1301:1311	any changes of organoid structural morphology	1301:1345	Furthermore, the encapsulation did not result in any changes of organoid structural morphology.
34198162	6	44	theme	soft	1153:1156	arg1	hydrogel					1191:1198	a soft, thiol-ene cross-linked alginate hydrogel	1151:1198	hydrogel	1191:1198	Encapsulating organoids for four days in a soft, thiol-ene cross-linked alginate hydrogel resulted in decreased type 1a1 collagen expression.
34198162	7	45	theme	structural	1325:1334	arg1	morphology					1336:1345	organoid structural morphology	1316:1345	organoid structural morphology	1316:1345	Furthermore, the encapsulation did not result in any changes of organoid structural morphology.
34198162	4	46	theme	key	854:856	arg1	functions					858:866	key functions	854:866	key functions of the human kidney	854:886	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	5	47	dep	in	1014:1015	arg1	vivo					1017:1020	vivo	1017:1020	vivo	1017:1020	Here we hypothesized the need for a three-dimensional environment to grow the kidney organoids, which could better mimic the in vivo surroundings of the developing kidney than standard culture on an air-liquid interface.
34198162	2	48	theme	developmental	428:440	arg1	plateau					442:448	their developmental plateau	422:448	their developmental plateau	422:448	Before these organoids can be translated to the clinic, shortcomings regarding their cellular and extracellular compositions, and their developmental plateau need to be overcome.
34198162	8	49	theme	expression	1502:1511	arg1	reduction					1462:1470	a reduction	1460:1470	a reduction of abnormal type 1a1 collagen expression	1460:1511	Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application.
34198162	8	49	theme	expression	1502:1511	arg1	culture					1439:1445	a prolonged kidney organoid culture	1411:1445	a prolonged kidney organoid culture in vitro	1411:1454	Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application.
34198162	5	50	theme	developing	1042:1051	arg1	kidney					1053:1058	the developing kidney	1038:1058	the developing kidney	1038:1058	Here we hypothesized the need for a three-dimensional environment to grow the kidney organoids, which could better mimic the in vivo surroundings of the developing kidney than standard culture on an air-liquid interface.
34198162	8	51	theme	1a1	1489:1491	arg1	expression					1502:1511	abnormal type 1a1 collagen expression	1475:1511	abnormal type 1a1 collagen expression	1475:1511	Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application.
34198162	3	52	theme	proteomic	486:494	arg1	analysis					496:503	a proteomic analysis	484:503	a proteomic analysis	484:503	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	0	53	theme	extracellular	69:81	arg1	matrix					83:88	the extracellular matrix	65:88	the extracellular matrix of kidney organoids	65:108	Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition.
34198162	8	54	theme	prolonged	1413:1421	arg1	culture					1439:1445	a prolonged kidney organoid culture	1411:1445	a prolonged kidney organoid culture in vitro	1411:1454	Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application.
34198162	8	55	theme	collagen	1493:1500	arg1	expression					1502:1511	abnormal type 1a1 collagen expression	1475:1511	abnormal type 1a1 collagen expression	1475:1511	Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application.
34198162	3	56	theme	extracellular	601:613	arg1	composition					622:632	the extracellular matrix composition	597:632	the extracellular matrix composition	597:632	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	4	57	theme	collagen	737:744	arg1	types					746:750	specific collagen types	728:750	specific collagen types	728:750	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	5	58	theme	standard	1065:1072	arg1	culture					1074:1080	standard culture	1065:1080	standard culture	1065:1080	Here we hypothesized the need for a three-dimensional environment to grow the kidney organoids, which could better mimic the in vivo surroundings of the developing kidney than standard culture on an air-liquid interface.
34198162	3	59	theme	matrix	615:620	arg1	composition					622:632	the extracellular matrix composition	597:632	the extracellular matrix composition	597:632	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	4	60	theme	specific	728:735	arg1	types					746:750	specific collagen types	728:750	specific collagen types	728:750	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	5	61	theme	in	1014:1015	arg1	surroundings					1022:1033	the in vivo surroundings	1010:1033	the in vivo surroundings of the developing kidney than standard culture	1010:1080	Here we hypothesized the need for a three-dimensional environment to grow the kidney organoids, which could better mimic the in vivo surroundings of the developing kidney than standard culture on an air-liquid interface.
34198162	4	62	theme	pathological	815:826	arg1	condition					828:836	a life-threatening pathological condition	796:836	a life-threatening pathological condition	796:836	Such an excessive accumulation of specific collagen types is a hallmark of renal fibrosis that causes a life-threatening pathological condition by compromising key functions of the human kidney.
34198162	3	63	theme	kidney	508:513	arg1	organoids					515:523	kidney organoids	508:523	kidney organoids cultured for a prolonged culture time	508:561	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	3	64	from	change	587:592	arg1	composition					622:632	the extracellular matrix composition	597:632	the extracellular matrix composition	597:632	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	3	65	theme	6a1	680:682	arg1	collagen					684:691	6a1 collagen	680:691	6a1 collagen	680:691	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	3	66	theme	types	663:667	arg1	expression					649:658	increased expression	639:658	increased expression of types 1a1, 2 and 6a1 collagen	639:691	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	1	67	with	patients	261:268	arg1	diseases					282:289	kidney diseases	275:289	kidney diseases	275:289	Differentiated kidney organoids from induced pluripotent stem cells hold promise as a treatment for patients with kidney diseases.
34198162	1	68	theme	kidney	176:181	arg1	organoids					183:191	Differentiated kidney organoids	161:191	Differentiated kidney organoids from induced pluripotent stem cells	161:227	Differentiated kidney organoids from induced pluripotent stem cells hold promise as a treatment for patients with kidney diseases.
34198162	8	69	theme	collagen	1380:1387	arg1	expression					1389:1398	collagen expression	1380:1398	collagen expression	1380:1398	Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application.
34198162	3	70	dep	types	663:667	arg1	1a1					669:671	1a1	669:671	1a1	669:671	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	3	71	theme	collagen	684:691	arg1	expression					649:658	increased expression	639:658	increased expression of types 1a1, 2 and 6a1 collagen	639:691	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	3	72	theme	increased	639:647	arg1	expression					649:658	increased expression	639:658	increased expression of types 1a1, 2 and 6a1 collagen	639:691	We performed a proteomic analysis on kidney organoids cultured for a prolonged culture time and we found a specific change in the extracellular matrix composition with increased expression of types 1a1, 2 and 6a1 collagen.
34198162	1	73	from	cells	223:227	arg1	organoids					183:191	Differentiated kidney organoids	161:191	Differentiated kidney organoids from induced pluripotent stem cells	161:227	Differentiated kidney organoids from induced pluripotent stem cells hold promise as a treatment for patients with kidney diseases.
34198162	1	74	theme	Differentiated	161:174	arg1	organoids					183:191	Differentiated kidney organoids	161:191	Differentiated kidney organoids from induced pluripotent stem cells	161:227	Differentiated kidney organoids from induced pluripotent stem cells hold promise as a treatment for patients with kidney diseases.
34198162	8	75	theme	organoid	1430:1437	arg1	culture					1439:1445	a prolonged kidney organoid culture	1411:1445	a prolonged kidney organoid culture in vitro	1411:1454	Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application.
34198162	8	76	theme	clinical	1549:1556	arg1	application					1558:1568	clinical application	1549:1568	clinical application	1549:1568	Using a biomaterial to modulate collagen expression allows for a prolonged kidney organoid culture in vitro and a reduction of abnormal type 1a1 collagen expression bringing kidney organoids closer to clinical application.
34198162	6	77	theme	1a1	1227:1229	arg1	collagen					1231:1238	type 1a1 collagen	1222:1238	decreased type 1a1 collagen expression	1212:1249	Encapsulating organoids for four days in a soft, thiol-ene cross-linked alginate hydrogel resulted in decreased type 1a1 collagen expression.
34198162	2	78	theme	extracellular	390:402	arg1	compositions					404:415	their cellular and extracellular compositions	371:415	their cellular and extracellular compositions	371:415	Before these organoids can be translated to the clinic, shortcomings regarding their cellular and extracellular compositions, and their developmental plateau need to be overcome.
34198162	7	79	theme	organoid	1316:1323	arg1	morphology					1336:1345	organoid structural morphology	1316:1345	organoid structural morphology	1316:1345	Furthermore, the encapsulation did not result in any changes of organoid structural morphology.
32475918	5	0	theme	splenocytes	726:736	arg1	responses					713:721	the proliferative responses	695:721	the proliferative responses of splenocytes	695:736	PSP increased thymus and spleen indices, enhance the proliferative responses of splenocytes, and increased the phagocytosis of mononuclear macrophages.
32475918	4	1	theme	monosaccharide	500:513	arg1	components					515:524	The monosaccharide components	496:524	The monosaccharide components of PSP	496:531	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	4	1	theme	monosaccharide	500:513	arg1	galactose					538:546	galactose	538:546	galactose	538:546	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	10	2	theme	normal	1476:1481	arg1	mice					1483:1486	normal mice	1476:1486	normal mice	1476:1486	Taken together, PSP not only regulated the immune function of normal mice, but participated in the protection against immunosuppression in Cy-treated mice, highlighting its potential as an immunostimulant.
32475918	1	3	from	sibiricum	207:215	arg1	properties					144:153	physicochemical properties	128:153	physicochemical properties	128:153	In this study, we investigated the physicochemical properties and composition of monosaccharidex from Polygonatum sibiricum.
32475918	1	3	from	sibiricum	207:215	arg1	monosaccharidex					174:188	monosaccharidex	174:188	monosaccharidex from Polygonatum sibiricum	174:215	In this study, we investigated the physicochemical properties and composition of monosaccharidex from Polygonatum sibiricum.
32475918	1	3	from	sibiricum	207:215	arg1	composition					159:169	composition	159:169	composition	159:169	In this study, we investigated the physicochemical properties and composition of monosaccharidex from Polygonatum sibiricum.
32475918	1	4	theme	monosaccharidex	174:188	arg1	properties					144:153	physicochemical properties	128:153	physicochemical properties	128:153	In this study, we investigated the physicochemical properties and composition of monosaccharidex from Polygonatum sibiricum.
32475918	1	4	theme	monosaccharidex	174:188	arg1	composition					159:169	composition	159:169	composition	159:169	In this study, we investigated the physicochemical properties and composition of monosaccharidex from Polygonatum sibiricum.
32475918	9	5	theme	natural	1357:1363	arg1	killer					1365:1370	natural killer	1357:1370	natural killer cell activity	1357:1384	Additionally, PSP treatment accelerated the recovery of natural killer cell activity in a dose-dependent manner.
32475918	6	6	theme	normal	960:965	arg1	mice					967:970	cyclophosphamide (Cy)-treated and normal mice	926:970	cyclophosphamide (Cy)-treated and normal mice	926:970	Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, whilst blood leukocytes and platelet counts of Cy-treated mice recovered.
32475918	6	7	theme	blood	886:890	arg1	counts					904:909	blood erythrocyte counts	886:909	blood erythrocyte counts	886:909	Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, whilst blood leukocytes and platelet counts of Cy-treated mice recovered.
32475918	4	8	theme	PSP	529:531	arg1	components					515:524	The monosaccharide components	496:524	The monosaccharide components of PSP	496:531	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	4	8	theme	PSP	529:531	arg1	galactose					538:546	galactose	538:546	galactose	538:546	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	2	9	dep	Polygonatum	314:324	arg1	sibiricum					326:334	sibiricum	326:334	sibiricum	326:334	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	0	10	from	Characterization	0:15	arg1	sibiricum					82:90	Polygonatum sibiricum	70:90	Polygonatum sibiricum	70:90	Characterization and Immunological Activities of Polysaccharides from Polygonatum sibiricum.
32475918	7	11	theme	CD4+/CD8+	1064:1072	arg1	ratio					1074:1078	the CD4+/CD8+ ratio	1060:1078	the CD4+/CD8+ ratio is a dose-dependent manner	1060:1105	PSP elevated the CD4+/CD8+ ratio is a dose-dependent manner and increased the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in the sera of Cy-treated mice.
32475918	1	12	from	composition	159:169	arg1	sibiricum					207:215	Polygonatum sibiricum	195:215	Polygonatum sibiricum	195:215	In this study, we investigated the physicochemical properties and composition of monosaccharidex from Polygonatum sibiricum.
32475918	1	13	dep	properties	144:153	arg1	the					124:126	the	124:126	the	124:126	In this study, we investigated the physicochemical properties and composition of monosaccharidex from Polygonatum sibiricum.
32475918	6	14	theme	-treated	947:954	arg1	mice					967:970	cyclophosphamide (Cy)-treated and normal mice	926:970	cyclophosphamide (Cy)-treated and normal mice	926:970	Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, whilst blood leukocytes and platelet counts of Cy-treated mice recovered.
32475918	2	15	from	changes	380:386	arg1	organs					398:403	immune organs	391:403	immune organs	391:403	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	2	15	from	changes	380:386	arg1	cells					413:417	immune cells	406:417	immune cells	406:417	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	2	15	from	changes	380:386	arg1	cytokines					424:432	cytokines	424:432	cytokines	424:432	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	2	16	theme	Polygonatum	314:324	arg1	activity					357:364	Polygonatum sibiricum polysaccharide (PSP) activity	314:364	Polygonatum sibiricum polysaccharide (PSP) activity	314:364	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	9	17	theme	killer	1365:1370	arg1	activity					1377:1384	natural killer cell activity	1357:1384	natural killer cell activity	1357:1384	Additionally, PSP treatment accelerated the recovery of natural killer cell activity in a dose-dependent manner.
32475918	6	18	theme	mice	866:869	arg1	mass					841:844	the body mass	832:844	the body mass of immunosuppressed mice	832:869	Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, whilst blood leukocytes and platelet counts of Cy-treated mice recovered.
32475918	4	19	theme	11.72 	611:616	arg1	ratio					602:606	a molar ratio	594:606	a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48	594:643	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	8	20	theme	spleen	1281:1286	arg1	lymphocytes					1288:1298	spleen lymphocytes	1281:1298	spleen lymphocytes	1281:1298	PSP further enhanced the expression of IL-2 and TNF-α in spleen lymphocytes.
32475918	6	21	theme	Cy-treated	1020:1029	arg1	mice					1031:1034	Cy-treated mice	1020:1034	Cy-treated mice	1020:1034	Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, whilst blood leukocytes and platelet counts of Cy-treated mice recovered.
32475918	6	22	theme	platelet	1001:1008	arg1	counts					1010:1015	platelet counts	1001:1015	platelet counts	1001:1015	Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, whilst blood leukocytes and platelet counts of Cy-treated mice recovered.
32475918	5	23	theme	proliferative	699:711	arg1	responses					713:721	the proliferative responses	695:721	the proliferative responses of splenocytes	695:736	PSP increased thymus and spleen indices, enhance the proliferative responses of splenocytes, and increased the phagocytosis of mononuclear macrophages.
32475918	6	24	theme	immunosuppressed	849:864	arg1	mice					866:869	immunosuppressed mice	849:869	immunosuppressed mice	849:869	Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, whilst blood leukocytes and platelet counts of Cy-treated mice recovered.
32475918	7	25	dep	ratio	1074:1078	arg1	manner					1100:1105	a dose-dependent manner	1083:1105	a dose-dependent manner	1083:1105	PSP elevated the CD4+/CD8+ ratio is a dose-dependent manner and increased the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in the sera of Cy-treated mice.
32475918	1	26	from	properties	144:153	arg1	sibiricum					207:215	Polygonatum sibiricum	195:215	Polygonatum sibiricum	195:215	In this study, we investigated the physicochemical properties and composition of monosaccharidex from Polygonatum sibiricum.
32475918	7	27	theme	interleukin-2	1135:1147	arg1	levels					1125:1130	the levels	1121:1130	the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in the sera of Cy-treated mice	1121:1221	PSP elevated the CD4+/CD8+ ratio is a dose-dependent manner and increased the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in the sera of Cy-treated mice.
32475918	6	28	theme	mice	1031:1034	arg1	leukocytes					986:995	blood leukocytes	980:995	blood leukocytes	980:995	Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, whilst blood leukocytes and platelet counts of Cy-treated mice recovered.
32475918	6	28	theme	mice	1031:1034	arg1	counts					1010:1015	platelet counts	1001:1015	platelet counts	1001:1015	Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, whilst blood leukocytes and platelet counts of Cy-treated mice recovered.
32475918	7	29	theme	necrosis	1166:1173	arg1	levels					1125:1130	the levels	1121:1130	the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in the sera of Cy-treated mice	1121:1221	PSP elevated the CD4+/CD8+ ratio is a dose-dependent manner and increased the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in the sera of Cy-treated mice.
32475918	10	30	dep	regulated	1443:1451	arg1	only					1438:1441	only	1438:1441	only	1438:1441	Taken together, PSP not only regulated the immune function of normal mice, but participated in the protection against immunosuppression in Cy-treated mice, highlighting its potential as an immunostimulant.
32475918	7	31	from	levels	1125:1130	arg1	sera					1199:1202	the sera	1195:1202	the sera of Cy-treated mice	1195:1221	PSP elevated the CD4+/CD8+ ratio is a dose-dependent manner and increased the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in the sera of Cy-treated mice.
32475918	3	32	theme	molecular	447:455	arg1	Mw					465:466	Mw	465:466	Mw	465:466	The average molecular weight (Mw) of PSP was 9.514 × 104 Da.
32475918	3	32	theme	molecular	447:455	arg1	weight					457:462	The average molecular weight	435:462	The average molecular weight (Mw) of PSP	435:474	The average molecular weight (Mw) of PSP was 9.514 × 104 Da.
32475918	3	32	theme	molecular	447:455	arg1	Da					492:493	9.514 × 104 Da	480:493	9.514 × 104 Da	480:493	The average molecular weight (Mw) of PSP was 9.514 × 104 Da.
32475918	5	33	theme	mononuclear	773:783	arg1	macrophages					785:795	mononuclear macrophages	773:795	mononuclear macrophages	773:795	PSP increased thymus and spleen indices, enhance the proliferative responses of splenocytes, and increased the phagocytosis of mononuclear macrophages.
32475918	8	34	from	expression	1249:1258	arg1	lymphocytes					1288:1298	spleen lymphocytes	1281:1298	spleen lymphocytes	1281:1298	PSP further enhanced the expression of IL-2 and TNF-α in spleen lymphocytes.
32475918	2	35	theme	immune	406:411	arg1	cells					413:417	immune cells	406:417	immune cells	406:417	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	5	36	theme	macrophages	785:795	arg1	phagocytosis					757:768	the phagocytosis	753:768	the phagocytosis of mononuclear macrophages	753:795	PSP increased thymus and spleen indices, enhance the proliferative responses of splenocytes, and increased the phagocytosis of mononuclear macrophages.
32475918	10	37	from	protection	1513:1522	arg1	mice					1564:1567	Cy-treated mice	1553:1567	Cy-treated mice	1553:1567	Taken together, PSP not only regulated the immune function of normal mice, but participated in the protection against immunosuppression in Cy-treated mice, highlighting its potential as an immunostimulant.
32475918	5	38	theme	thymus	660:665	arg1	indices					678:684	thymus and spleen indices	660:684	thymus and spleen indices	660:684	PSP increased thymus and spleen indices, enhance the proliferative responses of splenocytes, and increased the phagocytosis of mononuclear macrophages.
32475918	9	39	theme	cell	1372:1375	arg1	activity					1377:1384	natural killer cell activity	1357:1384	natural killer cell activity	1357:1384	Additionally, PSP treatment accelerated the recovery of natural killer cell activity in a dose-dependent manner.
32475918	3	40	theme	PSP	472:474	arg1	Mw					465:466	Mw	465:466	Mw	465:466	The average molecular weight (Mw) of PSP was 9.514 × 104 Da.
32475918	3	40	theme	PSP	472:474	arg1	weight					457:462	The average molecular weight	435:462	The average molecular weight (Mw) of PSP	435:474	The average molecular weight (Mw) of PSP was 9.514 × 104 Da.
32475918	3	40	theme	PSP	472:474	arg1	Da					492:493	9.514 × 104 Da	480:493	9.514 × 104 Da	480:493	The average molecular weight (Mw) of PSP was 9.514 × 104 Da.
32475918	0	41	theme	Immunological	21:33	arg1	Activities					35:44	Immunological Activities	21:44	Immunological Activities	21:44	Characterization and Immunological Activities of Polysaccharides from Polygonatum sibiricum.
32475918	2	42	theme	polysaccharide	336:349	arg1	activity					357:364	Polygonatum sibiricum polysaccharide (PSP) activity	314:364	Polygonatum sibiricum polysaccharide (PSP) activity	314:364	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	2	43	dep	in	250:251	arg1	vivo					253:256	vivo	253:256	vivo	253:256	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	0	44	theme	Polysaccharides	49:63	arg1	Characterization					0:15	Characterization	0:15	Characterization	0:15	Characterization and Immunological Activities of Polysaccharides from Polygonatum sibiricum.
32475918	0	44	theme	Polysaccharides	49:63	arg1	Activities					35:44	Immunological Activities	21:44	Immunological Activities	21:44	Characterization and Immunological Activities of Polysaccharides from Polygonatum sibiricum.
32475918	7	45	theme	mice	1218:1221	arg1	sera					1199:1202	the sera	1195:1202	the sera of Cy-treated mice	1195:1221	PSP elevated the CD4+/CD8+ ratio is a dose-dependent manner and increased the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in the sera of Cy-treated mice.
32475918	5	46	theme	spleen	671:676	arg1	indices					678:684	thymus and spleen indices	660:684	thymus and spleen indices	660:684	PSP increased thymus and spleen indices, enhance the proliferative responses of splenocytes, and increased the phagocytosis of mononuclear macrophages.
32475918	6	47	theme	body	836:839	arg1	mass					841:844	the body mass	832:844	the body mass of immunosuppressed mice	832:869	Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, whilst blood leukocytes and platelet counts of Cy-treated mice recovered.
32475918	2	48	theme	in	262:263	arg1	activity					288:295	the in vivo and in vitro immunomodulatory activity	246:295	the in vivo and in vitro immunomodulatory activity	246:295	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	2	49	dep	in	262:263	arg1	vitro					265:269	vitro	265:269	vitro	265:269	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	3	50	theme	average	439:445	arg1	Mw					465:466	Mw	465:466	Mw	465:466	The average molecular weight (Mw) of PSP was 9.514 × 104 Da.
32475918	3	50	theme	average	439:445	arg1	weight					457:462	The average molecular weight	435:462	The average molecular weight (Mw) of PSP	435:474	The average molecular weight (Mw) of PSP was 9.514 × 104 Da.
32475918	3	50	theme	average	439:445	arg1	Da					492:493	9.514 × 104 Da	480:493	9.514 × 104 Da	480:493	The average molecular weight (Mw) of PSP was 9.514 × 104 Da.
32475918	0	51	theme	Polygonatum	70:80	arg1	sibiricum					82:90	Polygonatum sibiricum	70:90	Polygonatum sibiricum	70:90	Characterization and Immunological Activities of Polysaccharides from Polygonatum sibiricum.
32475918	10	52	theme	immune	1457:1462	arg1	function					1464:1471	the immune function	1453:1471	the immune function of normal mice	1453:1486	Taken together, PSP not only regulated the immune function of normal mice, but participated in the protection against immunosuppression in Cy-treated mice, highlighting its potential as an immunostimulant.
32475918	0	53	from	sibiricum	82:90	arg1	Polysaccharides					49:63	Polysaccharides	49:63	Polysaccharides from Polygonatum sibiricum	49:90	Characterization and Immunological Activities of Polysaccharides from Polygonatum sibiricum.
32475918	0	53	from	sibiricum	82:90	arg1	Characterization					0:15	Characterization	0:15	Characterization	0:15	Characterization and Immunological Activities of Polysaccharides from Polygonatum sibiricum.
32475918	0	53	from	sibiricum	82:90	arg1	Activities					35:44	Immunological Activities	21:44	Immunological Activities	21:44	Characterization and Immunological Activities of Polysaccharides from Polygonatum sibiricum.
32475918	7	54	theme	Cy-treated	1207:1216	arg1	mice					1218:1221	Cy-treated mice	1207:1221	Cy-treated mice	1207:1221	PSP elevated the CD4+/CD8+ ratio is a dose-dependent manner and increased the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in the sera of Cy-treated mice.
32475918	6	55	theme	erythrocyte	892:902	arg1	counts					904:909	blood erythrocyte counts	886:909	blood erythrocyte counts	886:909	Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, whilst blood leukocytes and platelet counts of Cy-treated mice recovered.
32475918	2	56	theme	in	250:251	arg1	activity					288:295	the in vivo and in vitro immunomodulatory activity	246:295	the in vivo and in vitro immunomodulatory activity	246:295	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	10	57	theme	Cy-treated	1553:1562	arg1	mice					1564:1567	Cy-treated mice	1553:1567	Cy-treated mice	1553:1567	Taken together, PSP not only regulated the immune function of normal mice, but participated in the protection against immunosuppression in Cy-treated mice, highlighting its potential as an immunostimulant.
32475918	1	58	theme	physicochemical	128:142	arg1	properties					144:153	physicochemical properties	128:153	physicochemical properties	128:153	In this study, we investigated the physicochemical properties and composition of monosaccharidex from Polygonatum sibiricum.
32475918	7	59	theme	dose-dependent	1085:1098	arg1	manner					1100:1105	a dose-dependent manner	1083:1105	a dose-dependent manner	1083:1105	PSP elevated the CD4+/CD8+ ratio is a dose-dependent manner and increased the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in the sera of Cy-treated mice.
32475918	4	60	dep	ratio	602:606	arg1	 1.78 					618:623	 1.78 	618:623	 1.78 	618:623	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	4	60	dep	ratio	602:606	arg1	 2.48					639:643	 2.48	639:643	 2.48	639:643	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	4	60	dep	ratio	602:606	arg1	 1.00 					632:637	 1.00 	632:637	 1.00 	632:637	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	4	60	dep	ratio	602:606	arg1	 4.15 					625:630	 4.15 	625:630	 4.15 	625:630	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	9	61	theme	PSP	1315:1317	arg1	treatment					1319:1327	PSP treatment	1315:1327	PSP treatment	1315:1327	Additionally, PSP treatment accelerated the recovery of natural killer cell activity in a dose-dependent manner.
32475918	4	62	theme	molar	596:600	arg1	ratio					602:606	a molar ratio	594:606	a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48	594:643	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	7	63	theme	tumor	1160:1164	arg1	necrosis					1166:1173	tumor necrosis factor-α	1160:1182	tumor necrosis factor-α (TNF-α)	1160:1190	PSP elevated the CD4+/CD8+ ratio is a dose-dependent manner and increased the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in the sera of Cy-treated mice.
32475918	7	63	theme	tumor	1160:1164	arg1	TNF-α					1185:1189	TNF-α	1185:1189	TNF-α	1185:1189	PSP elevated the CD4+/CD8+ ratio is a dose-dependent manner and increased the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in the sera of Cy-treated mice.
32475918	8	64	theme	TNF-α	1272:1276	arg1	expression					1249:1258	the expression	1245:1258	the expression of IL-2 and TNF-α in spleen lymphocytes	1245:1298	PSP further enhanced the expression of IL-2 and TNF-α in spleen lymphocytes.
32475918	2	65	theme	activity	357:364	arg1	mechanism					301:309	mechanism	301:309	mechanism of Polygonatum sibiricum polysaccharide (PSP) activity	301:364	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	2	65	theme	activity	357:364	arg1	activity					288:295	the in vivo and in vitro immunomodulatory activity	246:295	the in vivo and in vitro immunomodulatory activity	246:295	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	8	66	theme	IL-2	1263:1266	arg1	expression					1249:1258	the expression	1245:1258	the expression of IL-2 and TNF-α in spleen lymphocytes	1245:1298	PSP further enhanced the expression of IL-2 and TNF-α in spleen lymphocytes.
32475918	10	67	theme	mice	1483:1486	arg1	function					1464:1471	the immune function	1453:1471	the immune function of normal mice	1453:1486	Taken together, PSP not only regulated the immune function of normal mice, but participated in the protection against immunosuppression in Cy-treated mice, highlighting its potential as an immunostimulant.
32475918	2	68	theme	immunomodulatory	271:286	arg1	activity					288:295	the in vivo and in vitro immunomodulatory activity	246:295	the in vivo and in vitro immunomodulatory activity	246:295	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	9	69	theme	dose-dependent	1391:1404	arg1	manner					1406:1411	a dose-dependent manner	1389:1411	a dose-dependent manner	1389:1411	Additionally, PSP treatment accelerated the recovery of natural killer cell activity in a dose-dependent manner.
32475918	2	70	theme	immune	391:396	arg1	organs					398:403	immune organs	391:403	immune organs	391:403	Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines.
32475918	9	71	theme	activity	1377:1384	arg1	recovery					1345:1352	the recovery	1341:1352	the recovery of natural killer cell activity	1341:1384	Additionally, PSP treatment accelerated the recovery of natural killer cell activity in a dose-dependent manner.
32475918	4	72	from	ratio	602:606	arg1	glucose					583:589	glucose	583:589	glucose	583:589	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	4	72	from	ratio	602:606	arg1	components					515:524	The monosaccharide components	496:524	The monosaccharide components of PSP	496:531	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	4	72	from	ratio	602:606	arg1	arabinose					559:567	arabinose	559:567	arabinose	559:567	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	4	72	from	ratio	602:606	arg1	mannose					570:576	mannose	570:576	mannose	570:576	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	4	72	from	ratio	602:606	arg1	galactose					538:546	galactose	538:546	galactose	538:546	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	4	72	from	ratio	602:606	arg1	rhamnose					549:556	rhamnose	549:556	rhamnose	549:556	The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72 : 1.78 : 4.15 : 1.00 : 2.48.
32475918	0	73	from	Activities	35:44	arg1	sibiricum					82:90	Polygonatum sibiricum	70:90	Polygonatum sibiricum	70:90	Characterization and Immunological Activities of Polysaccharides from Polygonatum sibiricum.
32475918	6	74	theme	blood	980:984	arg1	leukocytes					986:995	blood leukocytes	980:995	blood leukocytes	980:995	Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, whilst blood leukocytes and platelet counts of Cy-treated mice recovered.
32475918	6	75	theme	mice	967:970	arg1	sera					918:921	the sera	914:921	the sera of cyclophosphamide (Cy)-treated and normal mice	914:970	Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, whilst blood leukocytes and platelet counts of Cy-treated mice recovered.
33559180	10	0	theme	content	2005:2011	arg1	formulation					2013:2023	its initial content formulation	1993:2023	its initial content formulation	1993:2023	This approach involves decreasing the sugar particles size and demonstrates how reducing the content to half of its initial content formulation will affect the sensory perception and physical properties.
33559180	3	1	theme	content	610:616	arg1	%					630:630	the following content: Control 100%	596:630	the following content: Control 100%	596:630	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	1	theme	content	610:616	arg1	C					641:641	C	641:641	C	641:641	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	4	2	dep	physical	760:767	arg1	dimensions					770:779	dimensions	770:779	dimensions	770:779	Biscuits were tested using sensory (hedonic and intensity), physical (dimensions, fracture properties, color), and compositional analyses.
33559180	4	2	dep	physical	760:767	arg1	properties					791:800	fracture properties	782:800	fracture properties	782:800	Biscuits were tested using sensory (hedonic and intensity), physical (dimensions, fracture properties, color), and compositional analyses.
33559180	4	2	dep	physical	760:767	arg1	color					803:807	color	803:807	color	803:807	Biscuits were tested using sensory (hedonic and intensity), physical (dimensions, fracture properties, color), and compositional analyses.
33559180	5	3	theme	sugar	970:974	arg1	fractions					976:984	the Control and F- sugar fractions	951:984	fractions	976:984	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	9	4	theme	biscuits	1871:1878	arg1	reduction					1846:1854	sugar reduction	1840:1854	sugar reduction of short bread biscuits	1840:1878	This study investigates the use of a clean label approach in sugar reduction of short bread biscuits.
33559180	8	5	theme	particles	1624:1632	arg1	utilization					1597:1607	the utilization	1593:1607	the utilization	1593:1607	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	8	6	theme	PRACTICAL	1488:1496	arg1	APPLICATION					1498:1508	PRACTICAL APPLICATION	1488:1508	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.	1488:1777	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	3	7	dep	377 µm	514:519	arg1	to					511:512	to	511:512	to	511:512	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	7	8	theme	baked	1382:1386	arg1	goods					1388:1392	baked goods	1382:1392	baked goods	1382:1392	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	10	9	theme	physical	2064:2071	arg1	properties					2073:2082	physical properties	2064:2082	physical properties	2064:2082	This approach involves decreasing the sugar particles size and demonstrates how reducing the content to half of its initial content formulation will affect the sensory perception and physical properties.
33559180	5	10	from	acceptability	1024:1036	arg1	sizes					1087:1091	all three sugar fraction sizes	1062:1091	all three sugar fraction sizes	1062:1091	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	3	11	theme	Control	619:625	arg1	%					630:630	the following content: Control 100%	596:630	the following content: Control 100%	596:630	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	11	theme	Control	619:625	arg1	C					641:641	C	641:641	C	641:641	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	2	12	theme	sugar	274:278	arg1	fractions					285:293	different sugar size fractions	264:293	different sugar size fractions	264:293	The objective of this study was to determine if different sugar size fractions could increase the sweetness intensity of Shortbread biscuits and therefore, permit sugar reduction.
33559180	6	13	theme	baked	1257:1261	arg1	biscuits					1263:1270	low-sugar baked biscuits	1247:1270	low-sugar baked biscuits	1247:1270	As sweetness intensity scores correlated directly with flavor liking scores, these findings promote the use of this sugar fraction in the formulation of low-sugar baked biscuits.
33559180	8	14	from	content	1538:1544	arg1	products					1549:1556	products	1549:1556	products one of the approaches	1549:1578	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	6	15	from	use	1198:1200	arg1	formulation					1232:1242	the formulation	1228:1242	the formulation of low-sugar baked biscuits	1228:1270	As sweetness intensity scores correlated directly with flavor liking scores, these findings promote the use of this sugar fraction in the formulation of low-sugar baked biscuits.
33559180	5	16	from	product	1051:1057	arg1	sizes					1087:1091	all three sugar fraction sizes	1062:1091	all three sugar fraction sizes	1062:1091	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	1	17	theme	rich	116:119	arg1	diet					127:130	A rich sugar diet	114:130	A rich sugar diet	114:130	A rich sugar diet has negative health implications so it is necessary to reduce sugar where possible.
33559180	5	18	from	sizes	1087:1091	arg1	acceptability					1024:1036	acceptability	1024:1036	acceptability of the final product in all three sugar fraction sizes	1024:1091	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	5	19	with	C-sugar	877:883	arg1	content					898:904	its 50% content	890:904	its 50% content	890:904	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	8	20	theme	sweetness	1684:1692	arg1	intensity					1671:1679	the intensity	1667:1679	the intensity of sweetness in chocolate brownies	1667:1714	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	2	21	theme	study	238:242	arg1	objective					220:228	The objective	216:228	The objective of this study	216:242	The objective of this study was to determine if different sugar size fractions could increase the sweetness intensity of Shortbread biscuits and therefore, permit sugar reduction.
33559180	10	22	theme	particles	1925:1933	arg1	size					1935:1938	the sugar particles size	1915:1938	the sugar particles size	1915:1938	This approach involves decreasing the sugar particles size and demonstrates how reducing the content to half of its initial content formulation will affect the sensory perception and physical properties.
33559180	5	23	theme	final	1045:1049	arg1	product					1051:1057	the final product	1041:1057	the final product in all three sugar fraction sizes	1041:1091	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	8	24	theme	chocolate	1697:1705	arg1	brownies					1707:1714	chocolate brownies	1697:1714	chocolate brownies	1697:1714	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	1	25	theme	negative	136:143	arg1	implications					152:163	negative health implications	136:163	negative health implications	136:163	A rich sugar diet has negative health implications so it is necessary to reduce sugar where possible.
33559180	7	26	theme	biscuits	1469:1476	arg1	products					1478:1485	commercially available baked biscuits products	1440:1485	commercially available baked biscuits products	1440:1485	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	7	27	theme	viable	1325:1330	arg1	approach					1354:1361	a viable, cheap, technological approach	1323:1361	a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products	1323:1485	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	7	27	theme	viable	1325:1330	arg1	manipulation					1293:1304	Sugar particle size manipulation	1273:1304	Sugar particle size manipulation	1273:1304	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	9	28	theme	short	1859:1863	arg1	biscuits					1871:1878	short bread biscuits	1859:1878	short bread biscuits	1859:1878	This study investigates the use of a clean label approach in sugar reduction of short bread biscuits.
33559180	0	29	theme	different	72:80	arg1	fractions					103:111	different sucrose granule size fractions	72:111	different sucrose granule size fractions	72:111	The sensory and physical properties of Shortbread biscuits cooked using different sucrose granule size fractions.
33559180	5	30	theme	50	894:895	arg1	%					896:896	%	896:896	%	896:896	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	8	31	theme	small	1612:1616	arg1	particles					1624:1632	small sugar particles	1612:1632	small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies	1612:1714	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	7	32	theme	available	1453:1461	arg1	products					1478:1485	commercially available baked biscuits products	1440:1485	commercially available baked biscuits products	1440:1485	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	9	33	dep	approach	1828:1835	arg1	label					1822:1826	label	1822:1826	label	1822:1826	This study investigates the use of a clean label approach in sugar reduction of short bread biscuits.
33559180	8	34	dep	APPLICATION	1498:1508	arg1	utilization					1597:1607	the utilization	1593:1607	the utilization	1593:1607	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	0	35	theme	granule	90:96	arg1	fractions					103:111	different sucrose granule size fractions	72:111	different sucrose granule size fractions	72:111	The sensory and physical properties of Shortbread biscuits cooked using different sucrose granule size fractions.
33559180	8	36	theme	approaches	1569:1578	arg1	one					1558:1560	one	1558:1560	one	1558:1560	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	8	36	theme	approaches	1569:1578	arg1	approaches					1569:1578	the approaches	1565:1578	the approaches	1565:1578	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	3	37	theme	initial	683:689	arg1	content					691:697	its initial content	679:697	its initial content	679:697	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	5	38	theme	fraction	1078:1085	arg1	sizes					1087:1091	all three sugar fraction sizes	1062:1091	all three sugar fraction sizes	1062:1091	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	2	39	theme	sugar	379:383	arg1	reduction					385:393	sugar reduction	379:393	sugar reduction	379:393	The objective of this study was to determine if different sugar size fractions could increase the sweetness intensity of Shortbread biscuits and therefore, permit sugar reduction.
33559180	7	40	from	sugar	1373:1377	arg1	goods					1388:1392	baked goods	1382:1392	baked goods	1382:1392	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	7	41	theme	consumer	1416:1423	arg1	acceptable					1425:1434	consumer acceptable	1416:1434	consumer acceptable	1416:1434	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	7	42	used	used	1315:1318	arg2	manipulation					1293:1304	Sugar particle size manipulation	1273:1304	Sugar particle size manipulation	1273:1304	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	7	42	used	used	1315:1318	arg2	approach					1354:1361	a viable, cheap, technological approach	1323:1361	a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products	1323:1485	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	7	43	theme	size	1288:1291	arg1	approach					1354:1361	a viable, cheap, technological approach	1323:1361	a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products	1323:1485	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	7	43	theme	size	1288:1291	arg1	manipulation					1293:1304	Sugar particle size manipulation	1273:1304	Sugar particle size manipulation	1273:1304	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	3	44	theme	sugar	430:434	arg1	378 µm					453:458	378 µm	453:458	378 µm	453:458	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	44	theme	sugar	430:434	arg1	two					465:467	two	465:467	two	465:467	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	44	theme	sugar	430:434	arg1	sieved					476:481	sieved	476:481	sieved	476:481	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	44	theme	sugar	430:434	arg1	Control					437:443	the unground commercial sugar (Control	406:443	the unground commercial sugar (Control	406:443	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	7	45	theme	Sugar	1273:1277	arg1	size					1288:1291	Sugar particle size	1273:1291	Sugar particle size manipulation	1273:1304	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	6	46	theme	liking	1156:1161	arg1	scores					1163:1168	flavor liking scores	1149:1168	flavor liking scores	1149:1168	As sweetness intensity scores correlated directly with flavor liking scores, these findings promote the use of this sugar fraction in the formulation of low-sugar baked biscuits.
33559180	8	47	dep	products	1549:1556	arg1	one					1558:1560	one	1558:1560	one	1558:1560	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	8	47	dep	products	1549:1556	arg1	approaches					1569:1578	the approaches	1565:1578	the approaches	1565:1578	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	9	48	theme	clean	1816:1820	arg1	approach					1828:1835	a clean label approach	1814:1835	a clean label approach	1814:1835	This study investigates the use of a clean label approach in sugar reduction of short bread biscuits.
33559180	9	49	theme	approach	1828:1835	arg1	use					1807:1809	the use	1803:1809	the use of a clean label approach in sugar reduction of short bread biscuits	1803:1878	This study investigates the use of a clean label approach in sugar reduction of short bread biscuits.
33559180	9	50	theme	sugar	1840:1844	arg1	reduction					1846:1854	sugar reduction	1840:1854	sugar reduction of short bread biscuits	1840:1878	This study investigates the use of a clean label approach in sugar reduction of short bread biscuits.
33559180	1	51	contain	has	132:134	arg2	implications					152:163	negative health implications	136:163	negative health implications	136:163	A rich sugar diet has negative health implications so it is necessary to reduce sugar where possible.
33559180	1	51	contain	has	132:134	arg1	diet					127:130	A rich sugar diet	114:130	A rich sugar diet	114:130	A rich sugar diet has negative health implications so it is necessary to reduce sugar where possible.
33559180	2	52	theme	Shortbread	337:346	arg1	biscuits					348:355	Shortbread biscuits	337:355	Shortbread biscuits	337:355	The objective of this study was to determine if different sugar size fractions could increase the sweetness intensity of Shortbread biscuits and therefore, permit sugar reduction.
33559180	6	53	theme	sugar	1210:1214	arg1	fraction					1216:1223	this sugar fraction	1205:1223	this sugar fraction	1205:1223	As sweetness intensity scores correlated directly with flavor liking scores, these findings promote the use of this sugar fraction in the formulation of low-sugar baked biscuits.
33559180	3	54	dep	179 µm	542:547	arg1	to					539:540	to	539:540	to	539:540	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	10	55	theme	initial	1997:2003	arg1	formulation					2013:2023	its initial content formulation	1993:2023	its initial content formulation	1993:2023	This approach involves decreasing the sugar particles size and demonstrates how reducing the content to half of its initial content formulation will affect the sensory perception and physical properties.
33559180	4	56	theme	compositional	815:827	arg1	analyses					829:836	compositional analyses	815:836	compositional analyses	815:836	Biscuits were tested using sensory (hedonic and intensity), physical (dimensions, fracture properties, color), and compositional analyses.
33559180	3	57	theme	biscuit	571:577	arg1	formulation					579:589	biscuit formulation	571:589	biscuit formulation	571:589	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	8	58	theme	sugar	1618:1622	arg1	particles					1624:1632	small sugar particles	1612:1632	small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies	1612:1714	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	2	59	theme	different	264:272	arg1	fractions					285:293	different sugar size fractions	264:293	different sugar size fractions	264:293	The objective of this study was to determine if different sugar size fractions could increase the sweetness intensity of Shortbread biscuits and therefore, permit sugar reduction.
33559180	5	60	theme	F-	967:968	arg1	fractions					976:984	the Control and F- sugar fractions	951:984	fractions	976:984	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	8	61	from	intensity	1671:1679	arg1	brownies					1707:1714	chocolate brownies	1697:1714	chocolate brownies	1697:1714	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	9	62	theme	bread	1865:1869	arg1	biscuits					1871:1878	short bread biscuits	1859:1878	short bread biscuits	1859:1878	This study investigates the use of a clean label approach in sugar reduction of short bread biscuits.
33559180	3	63	theme	sieved	476:481	arg1	two					465:467	two	465:467	two	465:467	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	63	theme	sieved	476:481	arg1	sieved					476:481	sieved	476:481	sieved	476:481	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	63	theme	sieved	476:481	arg1	Control					437:443	the unground commercial sugar (Control	406:443	the unground commercial sugar (Control	406:443	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	0	64	theme	Shortbread	39:48	arg1	biscuits					50:57	Shortbread biscuits	39:57	Shortbread biscuits	39:57	The sensory and physical properties of Shortbread biscuits cooked using different sucrose granule size fractions.
33559180	3	65	theme	following	600:608	arg1	%					630:630	the following content: Control 100%	596:630	the following content: Control 100%	596:630	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	65	theme	following	600:608	arg1	C					641:641	C	641:641	C	641:641	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	10	66	theme	formulation	2013:2023	arg1	half					1985:1988	half	1985:1988	half of its initial content formulation	1985:2023	This approach involves decreasing the sugar particles size and demonstrates how reducing the content to half of its initial content formulation will affect the sensory perception and physical properties.
33559180	2	67	theme	size	280:283	arg1	fractions					285:293	different sugar size fractions	264:293	different sugar size fractions	264:293	The objective of this study was to determine if different sugar size fractions could increase the sweetness intensity of Shortbread biscuits and therefore, permit sugar reduction.
33559180	6	68	theme	biscuits	1263:1270	arg1	formulation					1232:1242	the formulation	1228:1242	the formulation of low-sugar baked biscuits	1228:1270	As sweetness intensity scores correlated directly with flavor liking scores, these findings promote the use of this sugar fraction in the formulation of low-sugar baked biscuits.
33559180	5	69	contain	containing	940:949	arg1	samples					932:938	samples	932:938	samples containing the Control and F- sugar fractions at the same level	932:1002	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	5	69	contain	containing	940:949	arg2	fractions					976:984	the Control and F- sugar fractions	951:984	fractions	976:984	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	5	69	contain	containing	940:949	arg2	Control					955:961	the Control and F- sugar fractions	951:984	Control	955:961	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	4	70	dep	sensory	727:733	arg1	intensity					748:756	intensity	748:756	intensity	748:756	Biscuits were tested using sensory (hedonic and intensity), physical (dimensions, fracture properties, color), and compositional analyses.
33559180	4	70	dep	sensory	727:733	arg1	hedonic					736:742	hedonic	736:742	hedonic	736:742	Biscuits were tested using sensory (hedonic and intensity), physical (dimensions, fracture properties, color), and compositional analyses.
33559180	7	71	dep	viable	1325:1330	arg1	technological					1340:1352	technological	1340:1352	technological	1340:1352	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	7	71	dep	viable	1325:1330	arg1	cheap					1333:1337	cheap	1333:1337	cheap	1333:1337	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	6	72	theme	low-sugar	1247:1255	arg1	biscuits					1263:1270	low-sugar baked biscuits	1247:1270	low-sugar baked biscuits	1247:1270	As sweetness intensity scores correlated directly with flavor liking scores, these findings promote the use of this sugar fraction in the formulation of low-sugar baked biscuits.
33559180	10	73	theme	sensory	2041:2047	arg1	perception					2049:2058	the sensory perception	2037:2058	the sensory perception	2037:2058	This approach involves decreasing the sugar particles size and demonstrates how reducing the content to half of its initial content formulation will affect the sensory perception and physical properties.
33559180	9	74	from	use	1807:1809	arg1	reduction					1846:1854	sugar reduction	1840:1854	sugar reduction of short bread biscuits	1840:1878	This study investigates the use of a clean label approach in sugar reduction of short bread biscuits.
33559180	3	75	dep	sieved	476:481	arg1	separates					483:491	separates	483:491	separates	483:491	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	1	76	theme	sugar	121:125	arg1	diet					127:130	A rich sugar diet	114:130	A rich sugar diet	114:130	A rich sugar diet has negative health implications so it is necessary to reduce sugar where possible.
33559180	6	77	theme	flavor	1149:1154	arg1	scores					1163:1168	flavor liking scores	1149:1168	flavor liking scores	1149:1168	As sweetness intensity scores correlated directly with flavor liking scores, these findings promote the use of this sugar fraction in the formulation of low-sugar baked biscuits.
33559180	8	78	theme	sucrose	1530:1536	arg1	content					1538:1544	sucrose content	1530:1544	sucrose content in products one of the approaches	1530:1578	PRACTICAL APPLICATION: In order to reduce sucrose content in products one of the approaches might be via the utilization of small sugar particles which has been shown to increase the intensity of sweetness in chocolate brownies, which has been previously shown by Richardson et al. in 2018.
33559180	10	79	theme	sugar	1919:1923	arg1	size					1935:1938	the sugar particles size	1915:1938	the sugar particles size	1915:1938	This approach involves decreasing the sugar particles size and demonstrates how reducing the content to half of its initial content formulation will affect the sensory perception and physical properties.
33559180	6	80	theme	intensity	1107:1115	arg1	scores					1117:1122	sweetness intensity scores	1097:1122	sweetness intensity scores	1097:1122	As sweetness intensity scores correlated directly with flavor liking scores, these findings promote the use of this sugar fraction in the formulation of low-sugar baked biscuits.
33559180	0	81	theme	sucrose	82:88	arg1	fractions					103:111	different sucrose granule size fractions	72:111	different sucrose granule size fractions	72:111	The sensory and physical properties of Shortbread biscuits cooked using different sucrose granule size fractions.
33559180	1	82	theme	health	145:150	arg1	implications					152:163	negative health implications	136:163	negative health implications	136:163	A rich sugar diet has negative health implications so it is necessary to reduce sugar where possible.
33559180	0	83	theme	size	98:101	arg1	fractions					103:111	different sucrose granule size fractions	72:111	different sucrose granule size fractions	72:111	The sensory and physical properties of Shortbread biscuits cooked using different sucrose granule size fractions.
33559180	5	84	theme	%	896:896	arg1	content					898:904	its 50% content	890:904	its 50% content	890:904	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	7	85	theme	baked	1463:1467	arg1	products					1478:1485	commercially available baked biscuits products	1440:1485	commercially available baked biscuits products	1440:1485	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	5	86	contain	containing	866:875	arg2	C-sugar					877:883	C-sugar	877:883	C-sugar with its 50% content	877:904	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	5	86	contain	containing	866:875	arg1	samples					858:864	samples	858:864	samples containing C-sugar with its 50% content	858:904	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	5	87	theme	sugar	1072:1076	arg1	sizes					1087:1091	all three sugar fraction sizes	1062:1091	all three sugar fraction sizes	1062:1091	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	6	88	theme	sweetness	1097:1105	arg1	scores					1117:1122	sweetness intensity scores	1097:1122	sweetness intensity scores	1097:1122	As sweetness intensity scores correlated directly with flavor liking scores, these findings promote the use of this sugar fraction in the formulation of low-sugar baked biscuits.
33559180	3	89	dep	378 µm	453:458	arg1	to					450:451	to	450:451	to	450:451	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	90	theme	commercial	419:428	arg1	378 µm					453:458	378 µm	453:458	378 µm	453:458	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	90	theme	commercial	419:428	arg1	two					465:467	two	465:467	two	465:467	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	90	theme	commercial	419:428	arg1	sieved					476:481	sieved	476:481	sieved	476:481	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	90	theme	commercial	419:428	arg1	Control					437:443	the unground commercial sugar (Control	406:443	the unground commercial sugar (Control	406:443	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	0	91	theme	sensory	4:10	arg1	properties					25:34	The sensory and physical properties	0:34	The sensory and physical properties of Shortbread biscuits	0:57	The sensory and physical properties of Shortbread biscuits cooked using different sucrose granule size fractions.
33559180	4	92	theme	fracture	782:789	arg1	dimensions					770:779	dimensions	770:779	dimensions	770:779	Biscuits were tested using sensory (hedonic and intensity), physical (dimensions, fracture properties, color), and compositional analyses.
33559180	4	92	theme	fracture	782:789	arg1	properties					791:800	fracture properties	782:800	fracture properties	782:800	Biscuits were tested using sensory (hedonic and intensity), physical (dimensions, fracture properties, color), and compositional analyses.
33559180	5	93	theme	product	1051:1057	arg1	acceptability					1024:1036	acceptability	1024:1036	acceptability of the final product in all three sugar fraction sizes	1024:1091	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
33559180	0	94	theme	physical	16:23	arg1	properties					25:34	The sensory and physical properties	0:34	The sensory and physical properties of Shortbread biscuits	0:57	The sensory and physical properties of Shortbread biscuits cooked using different sucrose granule size fractions.
33559180	3	95	theme	unground	410:417	arg1	378 µm					453:458	378 µm	453:458	378 µm	453:458	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	95	theme	unground	410:417	arg1	two					465:467	two	465:467	two	465:467	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	95	theme	unground	410:417	arg1	sieved					476:481	sieved	476:481	sieved	476:481	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	95	theme	unground	410:417	arg1	Control					437:443	the unground commercial sugar (Control	406:443	the unground commercial sugar (Control	406:443	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	0	96	theme	biscuits	50:57	arg1	properties					25:34	The sensory and physical properties	0:34	The sensory and physical properties of Shortbread biscuits	0:57	The sensory and physical properties of Shortbread biscuits cooked using different sucrose granule size fractions.
33559180	7	97	theme	particle	1279:1286	arg1	size					1288:1291	Sugar particle size	1273:1291	Sugar particle size manipulation	1273:1304	Sugar particle size manipulation could be used as a viable, cheap, technological approach to reduce sugar in baked goods and therefore promote consumer acceptable and commercially available baked biscuits products.
33559180	2	98	theme	sweetness	314:322	arg1	intensity					324:332	the sweetness intensity	310:332	the sweetness intensity of Shortbread biscuits	310:355	The objective of this study was to determine if different sugar size fractions could increase the sweetness intensity of Shortbread biscuits and therefore, permit sugar reduction.
33559180	3	99	dep	Control	437:443	arg1	Fine					525:528	Fine	525:528	Fine (F)	525:532	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	99	dep	Control	437:443	arg1	377 µm					514:519	377 µm	514:519	377 µm	514:519	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	99	dep	Control	437:443	arg1	C					503:503	C	503:503	C	503:503	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	3	99	dep	Control	437:443	arg1	Coarse					495:500	Coarse	495:500	Coarse (C)	495:504	For this, the unground commercial sugar (Control, 102 to 378 µm) and two of its sieved separates, (Coarse (C), 228 to 377 µm and Fine (F), 124 to 179 µm) were investigated in biscuit formulation with the following content: Control 100% or 50%; (C), 100 or 50% and (F), 100 or 50% or its initial content.
33559180	2	100	theme	biscuits	348:355	arg1	intensity					324:332	the sweetness intensity	310:332	the sweetness intensity of Shortbread biscuits	310:355	The objective of this study was to determine if different sugar size fractions could increase the sweetness intensity of Shortbread biscuits and therefore, permit sugar reduction.
33559180	6	101	theme	fraction	1216:1223	arg1	use					1198:1200	the use	1194:1200	the use of this sugar fraction in the formulation of low-sugar baked biscuits	1194:1270	As sweetness intensity scores correlated directly with flavor liking scores, these findings promote the use of this sugar fraction in the formulation of low-sugar baked biscuits.
33559180	5	102	theme	same	993:996	arg1	level					998:1002	the same level	989:1002	the same level	989:1002	Trends showed that samples containing C-sugar with its 50% content were more preferable than samples containing the Control and F- sugar fractions at the same level without impact upon acceptability of the final product in all three sugar fraction sizes.
32512372	7	0	theme	breakthrough	1224:1235	arg1	curves					1237:1242	the breakthrough curves	1220:1242	the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa	1220:1324	The carboxylated cellulose filter exhibited high adsorption capability and high permeation flux evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa.
32512372	10	1	theme	cellulose	2048:2056	arg1	medium					2112:2117	a highly efficient adsorption medium	2082:2117	a highly efficient adsorption medium for industrial recovery of rare earth metals	2082:2162	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	10	1	theme	cellulose	2048:2056	arg1	filter					2058:2063	the carboxylated cellulose filter	2031:2063	the carboxylated cellulose filter	2031:2063	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	2	2	theme	adsorption	347:356	arg1	capability					358:367	high adsorption capability	342:367	high adsorption capability	342:367	These carboxylated cellulose filters were employed as sustainable filters for removal and recovery of lanthanum ions (La (III)) with high adsorption capability.
32512372	4	3	theme	mapping	585:591	arg1	approach					593:600	EDX mapping approach	581:600	EDX mapping approach	581:600	The distribution of La (III) on carboxylated cellulose fibers were explored by EDX mapping approach, which revealed that the adsorption occurred on both the surface and the internal structure of the cellulose fibers.
32512372	9	4	theme	carboxylated	1535:1546	arg1	mat					1566:1568	the carboxylated cellulose fibrous mat	1531:1568	the carboxylated cellulose fibrous mat	1531:1568	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	2	5	theme	lanthanum	311:319	arg1	La					327:328	La (III)	327:334	La (III)	327:334	These carboxylated cellulose filters were employed as sustainable filters for removal and recovery of lanthanum ions (La (III)) with high adsorption capability.
32512372	2	5	theme	lanthanum	311:319	arg1	ions					321:324	lanthanum ions	311:324	lanthanum ions (La (III)) with high adsorption capability	311:367	These carboxylated cellulose filters were employed as sustainable filters for removal and recovery of lanthanum ions (La (III)) with high adsorption capability.
32512372	5	6	theme	adsorption	753:762	arg1	kinetics					723:730	kinetics	723:730	kinetics	723:730	The kinetics and isotherms of the adsorption were conducted to understand the adsorption mechanism of the carboxylated cellulose filter and to learn the maximum adsorption capacity for La (III) which was as high as 33.7 mg/g.
32512372	5	6	theme	adsorption	753:762	arg1	isotherms					736:744	isotherms	736:744	isotherms	736:744	The kinetics and isotherms of the adsorption were conducted to understand the adsorption mechanism of the carboxylated cellulose filter and to learn the maximum adsorption capacity for La (III) which was as high as 33.7 mg/g.
32512372	5	7	theme	adsorption	797:806	arg1	mechanism					808:816	the adsorption mechanism	793:816	the adsorption mechanism of the carboxylated cellulose filter	793:853	The kinetics and isotherms of the adsorption were conducted to understand the adsorption mechanism of the carboxylated cellulose filter and to learn the maximum adsorption capacity for La (III) which was as high as 33.7 mg/g.
32512372	1	8	theme	TEMPO-mediated	183:196	arg1	oxidation					198:206	TEMPO-mediated oxidation	183:206	TEMPO-mediated oxidation	183:206	Carboxylated cellulose filters were fabricated by oxidation of a cellulose fibrous mat via TEMPO-mediated oxidation.
32512372	10	9	used	used	2074:2077	arg2	filter					2058:2063	the carboxylated cellulose filter	2031:2063	the carboxylated cellulose filter	2031:2063	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	10	9	used	used	2074:2077	arg2	medium					2112:2117	a highly efficient adsorption medium	2082:2117	a highly efficient adsorption medium for industrial recovery of rare earth metals	2082:2162	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	9	10	theme	massive	1644:1650	arg1	water					1673:1677	massive lanthanum-containing water	1644:1677	massive lanthanum-containing water	1644:1677	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	10	11	theme	efficient	2091:2099	arg1	medium					2112:2117	a highly efficient adsorption medium	2082:2117	a highly efficient adsorption medium for industrial recovery of rare earth metals	2082:2162	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	10	11	theme	efficient	2091:2099	arg1	filter					2058:2063	the carboxylated cellulose filter	2031:2063	the carboxylated cellulose filter	2031:2063	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	1	12	theme	cellulose	105:113	arg1	filters					115:121	Carboxylated cellulose filters	92:121	Carboxylated cellulose filters	92:121	Carboxylated cellulose filters were fabricated by oxidation of a cellulose fibrous mat via TEMPO-mediated oxidation.
32512372	10	13	theme	high	1730:1733	arg1	ratio					1745:1749	the high rejection ratio	1726:1749	the high rejection ratio of 94.3%	1726:1758	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	5	14	theme	carboxylated	825:836	arg1	filter					848:853	the carboxylated cellulose filter	821:853	the carboxylated cellulose filter	821:853	The kinetics and isotherms of the adsorption were conducted to understand the adsorption mechanism of the carboxylated cellulose filter and to learn the maximum adsorption capacity for La (III) which was as high as 33.7 mg/g.
32512372	8	15	theme	cellulose	1417:1425	arg1	filter					1427:1432	the carboxylated cellulose filter	1400:1432	the carboxylated cellulose filter	1400:1432	A variety of desorption reagents were selected to recover lanthanum from the carboxylated cellulose filter, where the optimized conditions for recovery were explored.
32512372	9	16	dep	removal	1593:1599	arg1	2.5 ppm					1630:1636	2.5 ppm	1630:1636	2.5 ppm	1630:1636	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	9	16	dep	removal	1593:1599	arg1	the					1589:1591	the	1589:1591	the	1589:1591	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	5	17	theme	filter	848:853	arg1	mechanism					808:816	the adsorption mechanism	793:816	the adsorption mechanism of the carboxylated cellulose filter	793:853	The kinetics and isotherms of the adsorption were conducted to understand the adsorption mechanism of the carboxylated cellulose filter and to learn the maximum adsorption capacity for La (III) which was as high as 33.7 mg/g.
32512372	5	18	dep	kinetics	723:730	arg1	The					719:721	The	719:721	The	719:721	The kinetics and isotherms of the adsorption were conducted to understand the adsorption mechanism of the carboxylated cellulose filter and to learn the maximum adsorption capacity for La (III) which was as high as 33.7 mg/g.
32512372	10	19	theme	industrial	2123:2132	arg1	recovery					2134:2141	industrial recovery	2123:2141	industrial recovery of rare earth metals	2123:2162	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	4	20	theme	fibers	711:716	arg1	structure					684:692	the internal structure	671:692	the internal structure of the cellulose fibers	671:716	The distribution of La (III) on carboxylated cellulose fibers were explored by EDX mapping approach, which revealed that the adsorption occurred on both the surface and the internal structure of the cellulose fibers.
32512372	4	20	theme	fibers	711:716	arg1	surface					659:665	the surface	655:665	the surface	655:665	The distribution of La (III) on carboxylated cellulose fibers were explored by EDX mapping approach, which revealed that the adsorption occurred on both the surface and the internal structure of the cellulose fibers.
32512372	10	21	theme	low	1783:1785	arg1	drop					1796:1799	the low pressure drop	1779:1799	the low pressure drop of 3.0 kPa remaining throughout the separation process	1779:1854	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	6	22	theme	filter	1002:1007	arg1	selectivity					960:970	The adsorption selectivity	945:970	The adsorption selectivity of the carboxylated cellulose filter for La (III)	945:1020	The adsorption selectivity of the carboxylated cellulose filter for La (III) was determined when interfering ions including mono- and di-covalent ions were involved.
32512372	10	23	theme	earth	2151:2155	arg1	metals					2157:2162	rare earth metals	2146:2162	rare earth metals	2146:2162	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	5	24	theme	adsorption	880:889	arg1	capacity					891:898	the maximum adsorption capacity	868:898	the maximum adsorption capacity for La (III) which was as high as 33.7 mg/g	868:942	The kinetics and isotherms of the adsorption were conducted to understand the adsorption mechanism of the carboxylated cellulose filter and to learn the maximum adsorption capacity for La (III) which was as high as 33.7 mg/g.
32512372	6	25	theme	carboxylated	979:990	arg1	filter					1002:1007	the carboxylated cellulose filter	975:1007	the carboxylated cellulose filter	975:1007	The adsorption selectivity of the carboxylated cellulose filter for La (III) was determined when interfering ions including mono- and di-covalent ions were involved.
32512372	10	26	theme	adsorption	1993:2002	arg1	membranes					2004:2012	commercially available nanofibrous adsorption membranes	1958:2012	commercially available nanofibrous adsorption membranes	1958:2012	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	0	27	theme	lanthanum	81:89	arg1	recovery					69:76	recovery	69:76	recovery of lanthanum	69:89	Sustainable carboxylated cellulose filters for efficient removal and recovery of lanthanum.
32512372	0	27	theme	lanthanum	81:89	arg1	removal					57:63	efficient removal	47:63	efficient removal	47:63	Sustainable carboxylated cellulose filters for efficient removal and recovery of lanthanum.
32512372	1	28	theme	mat	175:177	arg1	oxidation					142:150	oxidation	142:150	oxidation of a cellulose fibrous mat via TEMPO-mediated oxidation	142:206	Carboxylated cellulose filters were fabricated by oxidation of a cellulose fibrous mat via TEMPO-mediated oxidation.
32512372	10	29	theme	available	1971:1979	arg1	membranes					2004:2012	commercially available nanofibrous adsorption membranes	1958:2012	commercially available nanofibrous adsorption membranes	1958:2012	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	7	30	theme	permeation	1191:1200	arg1	flux					1202:1205	high permeation flux	1186:1205	high permeation flux	1186:1205	The carboxylated cellulose filter exhibited high adsorption capability and high permeation flux evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa.
32512372	3	31	dep	investigated	473:484	arg1	III					464:466	III	464:466	III	464:466	The surface chemistry of the carboxylated cellulose fibers before and after adsorption of La (III) was investigated systematically.
32512372	6	32	theme	adsorption	949:958	arg1	selectivity					960:970	The adsorption selectivity	945:970	The adsorption selectivity of the carboxylated cellulose filter for La (III)	945:1020	The adsorption selectivity of the carboxylated cellulose filter for La (III) was determined when interfering ions including mono- and di-covalent ions were involved.
32512372	0	33	theme	efficient	47:55	arg1	removal					57:63	efficient removal	47:63	efficient removal	47:63	Sustainable carboxylated cellulose filters for efficient removal and recovery of lanthanum.
32512372	10	34	dep	21.4 L	1904:1909	arg1	up					1898:1899	up	1898:1899	up	1898:1899	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	7	35	theme	adsorption	1160:1169	arg1	capability					1171:1180	high adsorption capability	1155:1180	high adsorption capability	1155:1180	The carboxylated cellulose filter exhibited high adsorption capability and high permeation flux evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa.
32512372	9	36	theme	cellulose	1548:1556	arg1	mat					1566:1568	the carboxylated cellulose fibrous mat	1531:1568	the carboxylated cellulose fibrous mat	1531:1568	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	3	37	theme	surface	374:380	arg1	chemistry					382:390	The surface chemistry	370:390	The surface chemistry of the carboxylated cellulose fibers before and after adsorption of La	370:461	The surface chemistry of the carboxylated cellulose fibers before and after adsorption of La (III) was investigated systematically.
32512372	4	38	theme	carboxylated	534:545	arg1	fibers					557:562	carboxylated cellulose fibers	534:562	carboxylated cellulose fibers	534:562	The distribution of La (III) on carboxylated cellulose fibers were explored by EDX mapping approach, which revealed that the adsorption occurred on both the surface and the internal structure of the cellulose fibers.
32512372	8	39	theme	reagents	1351:1358	arg1	variety					1329:1335	A variety	1327:1335	A variety of desorption reagents	1327:1358	A variety of desorption reagents were selected to recover lanthanum from the carboxylated cellulose filter, where the optimized conditions for recovery were explored.
32512372	8	39	theme	reagents	1351:1358	arg1	reagents					1351:1358	desorption reagents	1340:1358	desorption reagents	1340:1358	A variety of desorption reagents were selected to recover lanthanum from the carboxylated cellulose filter, where the optimized conditions for recovery were explored.
32512372	0	40	theme	cellulose	25:33	arg1	filters					35:41	cellulose filters	25:41	cellulose filters	25:41	Sustainable carboxylated cellulose filters for efficient removal and recovery of lanthanum.
32512372	9	41	theme	mat	1566:1568	arg1	cartridge					1518:1526	a spiral wound cartridge	1503:1526	a spiral wound cartridge of the carboxylated cellulose fibrous mat	1503:1568	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	3	42	theme	fibers	422:427	arg1	chemistry					382:390	The surface chemistry	370:390	The surface chemistry of the carboxylated cellulose fibers before and after adsorption of La	370:461	The surface chemistry of the carboxylated cellulose fibers before and after adsorption of La (III) was investigated systematically.
32512372	10	43	theme	3.0 kPa	1804:1810	arg1	drop					1796:1799	the low pressure drop	1779:1799	the low pressure drop of 3.0 kPa remaining throughout the separation process	1779:1854	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	3	44	theme	La	460:461	arg1	adsorption					446:455	adsorption	446:455	adsorption of La	446:461	The surface chemistry of the carboxylated cellulose fibers before and after adsorption of La (III) was investigated systematically.
32512372	7	45	theme	cellulose	1128:1136	arg1	filter					1138:1143	The carboxylated cellulose filter	1111:1143	The carboxylated cellulose filter	1111:1143	The carboxylated cellulose filter exhibited high adsorption capability and high permeation flux evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa.
32512372	2	46	with	ions	321:324	arg1	capability					358:367	high adsorption capability	342:367	high adsorption capability	342:367	These carboxylated cellulose filters were employed as sustainable filters for removal and recovery of lanthanum ions (La (III)) with high adsorption capability.
32512372	3	47	theme	carboxylated	399:410	arg1	fibers					422:427	the carboxylated cellulose fibers	395:427	the carboxylated cellulose fibers before and after adsorption of La	395:461	The surface chemistry of the carboxylated cellulose fibers before and after adsorption of La (III) was investigated systematically.
32512372	2	48	theme	high	342:345	arg1	capability					358:367	high adsorption capability	342:367	high adsorption capability	342:367	These carboxylated cellulose filters were employed as sustainable filters for removal and recovery of lanthanum ions (La (III)) with high adsorption capability.
32512372	7	49	theme	La	1273:1274	arg1	adsorption					1259:1268	the dynamic adsorption	1247:1268	the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa	1247:1324	The carboxylated cellulose filter exhibited high adsorption capability and high permeation flux evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa.
32512372	10	50	theme	separation	1837:1846	arg1	process					1848:1854	the separation process	1833:1854	the separation process	1833:1854	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	7	51	theme	adsorption	1259:1268	arg1	curves					1237:1242	the breakthrough curves	1220:1242	the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa	1220:1324	The carboxylated cellulose filter exhibited high adsorption capability and high permeation flux evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa.
32512372	8	52	theme	carboxylated	1404:1415	arg1	filter					1427:1432	the carboxylated cellulose filter	1400:1432	the carboxylated cellulose filter	1400:1432	A variety of desorption reagents were selected to recover lanthanum from the carboxylated cellulose filter, where the optimized conditions for recovery were explored.
32512372	6	53	theme	mono-	1069:1073	arg1	ions					1091:1094	mono- and di-covalent ions	1069:1094	mono- and di-covalent ions	1069:1094	The adsorption selectivity of the carboxylated cellulose filter for La (III) was determined when interfering ions including mono- and di-covalent ions were involved.
32512372	9	54	theme	La	1621:1622	arg1	removal					1593:1599	removal	1593:1599	removal	1593:1599	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	9	54	theme	La	1621:1622	arg1	recovery					1609:1616	the recovery	1605:1616	the recovery of La	1605:1622	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	10	55	theme	carboxylated	2035:2046	arg1	medium					2112:2117	a highly efficient adsorption medium	2082:2117	a highly efficient adsorption medium for industrial recovery of rare earth metals	2082:2162	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	10	55	theme	carboxylated	2035:2046	arg1	filter					2058:2063	the carboxylated cellulose filter	2031:2063	the carboxylated cellulose filter	2031:2063	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	4	56	from	distribution	506:517	arg1	fibers					557:562	carboxylated cellulose fibers	534:562	carboxylated cellulose fibers	534:562	The distribution of La (III) on carboxylated cellulose fibers were explored by EDX mapping approach, which revealed that the adsorption occurred on both the surface and the internal structure of the cellulose fibers.
32512372	2	57	theme	ions	321:324	arg1	recovery					299:306	recovery	299:306	recovery	299:306	These carboxylated cellulose filters were employed as sustainable filters for removal and recovery of lanthanum ions (La (III)) with high adsorption capability.
32512372	2	57	theme	ions	321:324	arg1	removal					287:293	removal	287:293	removal	287:293	These carboxylated cellulose filters were employed as sustainable filters for removal and recovery of lanthanum ions (La (III)) with high adsorption capability.
32512372	4	58	theme	EDX	581:583	arg1	approach					593:600	EDX mapping approach	581:600	EDX mapping approach	581:600	The distribution of La (III) on carboxylated cellulose fibers were explored by EDX mapping approach, which revealed that the adsorption occurred on both the surface and the internal structure of the cellulose fibers.
32512372	10	59	theme	solution	1873:1880	arg1	volume					1882:1887	the treated solution volume	1861:1887	the treated solution volume	1861:1887	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	10	59	theme	solution	1873:1880	arg1	high					1893:1896	high	1893:1896	high	1893:1896	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	10	60	theme	adsorption	2101:2110	arg1	medium					2112:2117	a highly efficient adsorption medium	2082:2117	a highly efficient adsorption medium for industrial recovery of rare earth metals	2082:2162	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	10	60	theme	adsorption	2101:2110	arg1	filter					2058:2063	the carboxylated cellulose filter	2031:2063	the carboxylated cellulose filter	2031:2063	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	10	61	theme	rejection	1735:1743	arg1	ratio					1745:1749	the high rejection ratio	1726:1749	the high rejection ratio of 94.3%	1726:1758	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	9	62	theme	lanthanum-containing	1652:1671	arg1	water					1673:1677	massive lanthanum-containing water	1644:1677	massive lanthanum-containing water	1644:1677	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	9	63	theme	spiral	1505:1510	arg1	cartridge					1518:1526	a spiral wound cartridge	1503:1526	a spiral wound cartridge of the carboxylated cellulose fibrous mat	1503:1568	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	2	64	theme	sustainable	263:273	arg1	filters					275:281	sustainable filters	263:281	sustainable filters	263:281	These carboxylated cellulose filters were employed as sustainable filters for removal and recovery of lanthanum ions (La (III)) with high adsorption capability.
32512372	2	64	theme	sustainable	263:273	arg1	filters					238:244	These carboxylated cellulose filters	209:244	These carboxylated cellulose filters	209:244	These carboxylated cellulose filters were employed as sustainable filters for removal and recovery of lanthanum ions (La (III)) with high adsorption capability.
32512372	5	65	theme	cellulose	838:846	arg1	filter					848:853	the carboxylated cellulose filter	821:853	the carboxylated cellulose filter	821:853	The kinetics and isotherms of the adsorption were conducted to understand the adsorption mechanism of the carboxylated cellulose filter and to learn the maximum adsorption capacity for La (III) which was as high as 33.7 mg/g.
32512372	10	66	theme	%	1758:1758	arg1	ratio					1745:1749	the high rejection ratio	1726:1749	the high rejection ratio of 94.3%	1726:1758	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	8	67	theme	optimized	1445:1453	arg1	conditions					1455:1464	the optimized conditions	1441:1464	the optimized conditions for recovery	1441:1477	A variety of desorption reagents were selected to recover lanthanum from the carboxylated cellulose filter, where the optimized conditions for recovery were explored.
32512372	2	68	theme	cellulose	228:236	arg1	filters					275:281	sustainable filters	263:281	sustainable filters	263:281	These carboxylated cellulose filters were employed as sustainable filters for removal and recovery of lanthanum ions (La (III)) with high adsorption capability.
32512372	2	68	theme	cellulose	228:236	arg1	filters					238:244	These carboxylated cellulose filters	209:244	These carboxylated cellulose filters	209:244	These carboxylated cellulose filters were employed as sustainable filters for removal and recovery of lanthanum ions (La (III)) with high adsorption capability.
32512372	10	69	theme	pressure	1787:1794	arg1	drop					1796:1799	the low pressure drop	1779:1799	the low pressure drop of 3.0 kPa remaining throughout the separation process	1779:1854	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	10	70	theme	metals	2157:2162	arg1	recovery					2134:2141	industrial recovery	2123:2141	industrial recovery of rare earth metals	2123:2162	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	4	71	theme	cellulose	701:709	arg1	fibers					711:716	the cellulose fibers	697:716	the cellulose fibers	697:716	The distribution of La (III) on carboxylated cellulose fibers were explored by EDX mapping approach, which revealed that the adsorption occurred on both the surface and the internal structure of the cellulose fibers.
32512372	5	72	theme	maximum	872:878	arg1	capacity					891:898	the maximum adsorption capacity	868:898	the maximum adsorption capacity for La (III) which was as high as 33.7 mg/g	868:942	The kinetics and isotherms of the adsorption were conducted to understand the adsorption mechanism of the carboxylated cellulose filter and to learn the maximum adsorption capacity for La (III) which was as high as 33.7 mg/g.
32512372	6	73	theme	cellulose	992:1000	arg1	filter					1002:1007	the carboxylated cellulose filter	975:1007	the carboxylated cellulose filter	975:1007	The adsorption selectivity of the carboxylated cellulose filter for La (III) was determined when interfering ions including mono- and di-covalent ions were involved.
32512372	7	74	theme	0.07 kPa	1317:1324	arg1	pressure					1305:1312	an extremely low pressure	1288:1312	an extremely low pressure of 0.07 kPa	1288:1324	The carboxylated cellulose filter exhibited high adsorption capability and high permeation flux evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa.
32512372	10	75	theme	rare	2146:2149	arg1	earth					2151:2155	rare earth	2146:2155	rare earth metals	2146:2162	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	1	76	theme	fibrous	167:173	arg1	mat					175:177	a cellulose fibrous mat	155:177	a cellulose fibrous mat via TEMPO-mediated oxidation	155:206	Carboxylated cellulose filters were fabricated by oxidation of a cellulose fibrous mat via TEMPO-mediated oxidation.
32512372	9	77	from	water	1673:1677	arg1	removal					1593:1599	removal	1593:1599	removal	1593:1599	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	9	77	from	water	1673:1677	arg1	recovery					1609:1616	the recovery	1605:1616	the recovery of La	1605:1622	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	4	78	theme	La	522:523	arg1	distribution					506:517	The distribution	502:517	The distribution of La (III) on carboxylated cellulose fibers	502:562	The distribution of La (III) on carboxylated cellulose fibers were explored by EDX mapping approach, which revealed that the adsorption occurred on both the surface and the internal structure of the cellulose fibers.
32512372	7	79	dep	exhibited	1145:1153	arg1	evidenced					1207:1215	evidenced	1207:1215	evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa	1207:1324	The carboxylated cellulose filter exhibited high adsorption capability and high permeation flux evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa.
32512372	4	80	theme	internal	675:682	arg1	structure					684:692	the internal structure	671:692	the internal structure of the cellulose fibers	671:716	The distribution of La (III) on carboxylated cellulose fibers were explored by EDX mapping approach, which revealed that the adsorption occurred on both the surface and the internal structure of the cellulose fibers.
32512372	10	81	theme	nanofibrous	1981:1991	arg1	membranes					2004:2012	commercially available nanofibrous adsorption membranes	1958:2012	commercially available nanofibrous adsorption membranes	1958:2012	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	7	82	theme	high	1186:1189	arg1	flux					1202:1205	high permeation flux	1186:1205	high permeation flux	1186:1205	The carboxylated cellulose filter exhibited high adsorption capability and high permeation flux evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa.
32512372	9	83	theme	wound	1512:1516	arg1	cartridge					1518:1526	a spiral wound cartridge	1503:1526	a spiral wound cartridge of the carboxylated cellulose fibrous mat	1503:1568	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	6	84	theme	di-covalent	1079:1089	arg1	ions					1091:1094	mono- and di-covalent ions	1069:1094	mono- and di-covalent ions	1069:1094	The adsorption selectivity of the carboxylated cellulose filter for La (III) was determined when interfering ions including mono- and di-covalent ions were involved.
32512372	7	85	theme	low	1301:1303	arg1	pressure					1305:1312	an extremely low pressure	1288:1312	an extremely low pressure of 0.07 kPa	1288:1324	The carboxylated cellulose filter exhibited high adsorption capability and high permeation flux evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa.
32512372	7	86	theme	high	1155:1158	arg1	capability					1171:1180	high adsorption capability	1155:1180	high adsorption capability	1155:1180	The carboxylated cellulose filter exhibited high adsorption capability and high permeation flux evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa.
32512372	1	87	theme	Carboxylated	92:103	arg1	filters					115:121	Carboxylated cellulose filters	92:121	Carboxylated cellulose filters	92:121	Carboxylated cellulose filters were fabricated by oxidation of a cellulose fibrous mat via TEMPO-mediated oxidation.
32512372	4	88	theme	cellulose	547:555	arg1	fibers					557:562	carboxylated cellulose fibers	534:562	carboxylated cellulose fibers	534:562	The distribution of La (III) on carboxylated cellulose fibers were explored by EDX mapping approach, which revealed that the adsorption occurred on both the surface and the internal structure of the cellulose fibers.
32512372	9	89	theme	fibrous	1558:1564	arg1	mat					1566:1568	the carboxylated cellulose fibrous mat	1531:1568	the carboxylated cellulose fibrous mat	1531:1568	Finally, a spiral wound cartridge of the carboxylated cellulose fibrous mat was fabricated and the removal and the recovery of La (III, 2.5 ppm) from massive lanthanum-containing water were demonstrated.
32512372	8	90	theme	desorption	1340:1349	arg1	reagents					1351:1358	desorption reagents	1340:1358	desorption reagents	1340:1358	A variety of desorption reagents were selected to recover lanthanum from the carboxylated cellulose filter, where the optimized conditions for recovery were explored.
32512372	7	91	theme	carboxylated	1115:1126	arg1	filter					1138:1143	The carboxylated cellulose filter	1111:1143	The carboxylated cellulose filter	1111:1143	The carboxylated cellulose filter exhibited high adsorption capability and high permeation flux evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa.
32512372	6	92	theme	interfering	1042:1052	arg1	ions					1091:1094	mono- and di-covalent ions	1069:1094	mono- and di-covalent ions	1069:1094	The adsorption selectivity of the carboxylated cellulose filter for La (III) was determined when interfering ions including mono- and di-covalent ions were involved.
32512372	6	92	theme	interfering	1042:1052	arg1	ions					1054:1057	interfering ions	1042:1057	interfering ions including mono- and di-covalent ions	1042:1094	The adsorption selectivity of the carboxylated cellulose filter for La (III) was determined when interfering ions including mono- and di-covalent ions were involved.
32512372	3	93	theme	cellulose	412:420	arg1	fibers					422:427	the carboxylated cellulose fibers	395:427	the carboxylated cellulose fibers before and after adsorption of La	395:461	The surface chemistry of the carboxylated cellulose fibers before and after adsorption of La (III) was investigated systematically.
32512372	1	94	theme	cellulose	157:165	arg1	mat					175:177	a cellulose fibrous mat	155:177	a cellulose fibrous mat via TEMPO-mediated oxidation	155:206	Carboxylated cellulose filters were fabricated by oxidation of a cellulose fibrous mat via TEMPO-mediated oxidation.
32512372	7	95	theme	dynamic	1251:1257	arg1	adsorption					1259:1268	the dynamic adsorption	1247:1268	the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa	1247:1324	The carboxylated cellulose filter exhibited high adsorption capability and high permeation flux evidenced by the breakthrough curves of the dynamic adsorption of La (III) under an extremely low pressure of 0.07 kPa.
32512372	2	96	theme	carboxylated	215:226	arg1	filters					275:281	sustainable filters	263:281	sustainable filters	263:281	These carboxylated cellulose filters were employed as sustainable filters for removal and recovery of lanthanum ions (La (III)) with high adsorption capability.
32512372	2	96	theme	carboxylated	215:226	arg1	filters					238:244	These carboxylated cellulose filters	209:244	These carboxylated cellulose filters	209:244	These carboxylated cellulose filters were employed as sustainable filters for removal and recovery of lanthanum ions (La (III)) with high adsorption capability.
32512372	10	97	theme	treated	1865:1871	arg1	volume					1882:1887	the treated solution volume	1861:1887	the treated solution volume	1861:1887	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
32512372	10	97	theme	treated	1865:1871	arg1	high					1893:1896	high	1893:1896	high	1893:1896	It was very impressive that the high rejection ratio of 94.3% was achieved under the low pressure drop of 3.0 kPa remaining throughout the separation process, and the treated solution volume was high up to 21.4 L, which was about six-times higher than that of commercially available nanofibrous adsorption membranes, indicating that the carboxylated cellulose filter could be used as a highly efficient adsorption medium for industrial recovery of rare earth metals.
34144414	6	0	theme	antibacterial	1022:1034	arg1	activity					1036:1043	good antibacterial activity	1017:1043	good antibacterial activity	1017:1043	Importantly, the films presented good antibacterial activity and excellent safety.
34144414	3	1	theme	hydrothermal	305:316	arg1	methods					329:335	green hydrothermal carbonized methods	299:335	green hydrothermal carbonized methods	299:335	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	7	2	theme	AgNPs	1147:1151	arg1	agent					1167:1171	AgNPs antibacterial agent	1147:1171	AgNPs antibacterial agent	1147:1171	These results will provide a theoretical basis for the green and safe design of AgNPs antibacterial agent.
34144414	5	3	theme	micro-nanometer	914:928	arg1	behavior					938:945	the micro-nanometer filling behavior	910:945	the micro-nanometer filling behavior	910:945	Two carbon spheres/AgNPs regulated the microstructure of chitosan-based films because of the electrostatic interaction and the micro-nanometer filling behavior, thus further immobilized the AgNPs.
34144414	6	4	theme	good	1017:1020	arg1	activity					1036:1043	good antibacterial activity	1017:1043	good antibacterial activity	1017:1043	Importantly, the films presented good antibacterial activity and excellent safety.
34144414	3	5	from	SMCS-Ag	630:636	arg1	%					658:658	only about 5.63%	643:658	only about 5.63%	643:658	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	3	5	from	SMCS-Ag	630:636	arg1	release					590:596	the release	586:596	the release of total Ag from AgNPs-SMCS and SMCS-Ag	586:636	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	7	6	theme	safe	1132:1135	arg1	design					1137:1142	the green and safe design	1118:1142	the green and safe design of AgNPs antibacterial agent	1118:1171	These results will provide a theoretical basis for the green and safe design of AgNPs antibacterial agent.
34144414	3	7	theme	immobilization	545:558	arg1	efficiency					560:569	high immobilization efficiency	540:569	high immobilization efficiency for AgNPs	540:579	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	3	8	used	used	342:345	arg2	kinds					290:294	two kinds	286:294	two kinds of green hydrothermal carbonized methods	286:335	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	5	9	theme	carbon	791:796	arg1	spheres/AgNPs					798:810	Two carbon spheres/AgNPs	787:810	Two carbon spheres/AgNPs	787:810	Two carbon spheres/AgNPs regulated the microstructure of chitosan-based films because of the electrostatic interaction and the micro-nanometer filling behavior, thus further immobilized the AgNPs.
34144414	3	10	theme	Glutinous	430:438	arg1	AgNPs-SMCS					462:471	Glutinous rice sesameballs-like AgNPs-SMCS	430:471	Glutinous rice sesameballs-like AgNPs-SMCS	430:471	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	7	11	theme	agent	1167:1171	arg1	design					1137:1142	the green and safe design	1118:1142	the green and safe design of AgNPs antibacterial agent	1118:1171	These results will provide a theoretical basis for the green and safe design of AgNPs antibacterial agent.
34144414	2	12	theme	cumulative	259:268	arg1	toxicity					270:277	the cumulative toxicity	255:277	the cumulative toxicity	255:277	As such, the quest for AgNPs should focus on controlling their release to reduce the cumulative toxicity.
34144414	3	13	from	AgNPs-SMCS	615:624	arg1	%					658:658	only about 5.63%	643:658	only about 5.63%	643:658	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	3	13	from	AgNPs-SMCS	615:624	arg1	release					590:596	the release	586:596	the release of total Ag from AgNPs-SMCS and SMCS-Ag	586:636	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	3	14	theme	rice	440:443	arg1	AgNPs-SMCS					462:471	Glutinous rice sesameballs-like AgNPs-SMCS	430:471	Glutinous rice sesameballs-like AgNPs-SMCS	430:471	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	0	15	theme	chitosan	14:21	arg1	films					33:37	Antibacterial chitosan composite films	0:37	Antibacterial chitosan composite films with food-inspired carbon spheres	0:71	Antibacterial chitosan composite films with food-inspired carbon spheres immobilized AgNPs.
34144414	1	16	from	application	143:153	arg1	packaging					163:171	food packaging	158:171	food packaging	158:171	The cumulative toxicity of AgNPs has limited their application in food packaging.
34144414	1	17	theme	cumulative	96:105	arg1	toxicity					107:114	The cumulative toxicity	92:114	The cumulative toxicity of AgNPs	92:123	The cumulative toxicity of AgNPs has limited their application in food packaging.
34144414	3	18	theme	spheres/AgNPs	415:427	arg1	kinds					399:403	two kinds	395:403	two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs	395:579	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	0	19	theme	Antibacterial	0:12	arg1	films					33:37	Antibacterial chitosan composite films	0:37	Antibacterial chitosan composite films with food-inspired carbon spheres	0:71	Antibacterial chitosan composite films with food-inspired carbon spheres immobilized AgNPs.
34144414	7	20	theme	green	1122:1126	arg1	design					1137:1142	the green and safe design	1118:1142	the green and safe design of AgNPs antibacterial agent	1118:1171	These results will provide a theoretical basis for the green and safe design of AgNPs antibacterial agent.
34144414	5	21	theme	electrostatic	880:892	arg1	interaction					894:904	the electrostatic interaction	876:904	the electrostatic interaction	876:904	Two carbon spheres/AgNPs regulated the microstructure of chitosan-based films because of the electrostatic interaction and the micro-nanometer filling behavior, thus further immobilized the AgNPs.
34144414	3	22	theme	sulfhydryl-modified	356:374	arg1	chitosan					376:383	sulfhydryl-modified chitosan	356:383	sulfhydryl-modified chitosan	356:383	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	7	23	theme	theoretical	1096:1106	arg1	basis					1108:1112	a theoretical basis	1094:1112	a theoretical basis for the green and safe design of AgNPs antibacterial agent	1094:1171	These results will provide a theoretical basis for the green and safe design of AgNPs antibacterial agent.
34144414	0	24	theme	composite	23:31	arg1	films					33:37	Antibacterial chitosan composite films	0:37	Antibacterial chitosan composite films with food-inspired carbon spheres	0:71	Antibacterial chitosan composite films with food-inspired carbon spheres immobilized AgNPs.
34144414	1	25	theme	AgNPs	119:123	arg1	toxicity					107:114	The cumulative toxicity	92:114	The cumulative toxicity of AgNPs	92:123	The cumulative toxicity of AgNPs has limited their application in food packaging.
34144414	3	26	theme	dragon	477:482	arg1	SMCS-Ag					495:501	dragon fruit-like SMCS-Ag	477:501	dragon fruit-like SMCS-Ag	477:501	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	0	27	theme	food-inspired	44:56	arg1	spheres					65:71	food-inspired carbon spheres	44:71	food-inspired carbon spheres	44:71	Antibacterial chitosan composite films with food-inspired carbon spheres immobilized AgNPs.
34144414	5	28	theme	chitosan-based	844:857	arg1	films					859:863	chitosan-based films	844:863	chitosan-based films	844:863	Two carbon spheres/AgNPs regulated the microstructure of chitosan-based films because of the electrostatic interaction and the micro-nanometer filling behavior, thus further immobilized the AgNPs.
34144414	3	29	dep	spheres/AgNPs	415:427	arg1	AgNPs-SMCS					462:471	Glutinous rice sesameballs-like AgNPs-SMCS	430:471	Glutinous rice sesameballs-like AgNPs-SMCS	430:471	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	3	29	dep	spheres/AgNPs	415:427	arg1	SMCS-Ag					495:501	dragon fruit-like SMCS-Ag	477:501	dragon fruit-like SMCS-Ag	477:501	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	3	30	theme	sesameballs-like	445:460	arg1	AgNPs-SMCS					462:471	Glutinous rice sesameballs-like AgNPs-SMCS	430:471	Glutinous rice sesameballs-like AgNPs-SMCS	430:471	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	3	31	theme	carbon	408:413	arg1	spheres/AgNPs					415:427	carbon spheres/AgNPs	408:427	carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag)	408:502	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	3	32	theme	total	601:605	arg1	Ag					607:608	total Ag	601:608	total Ag	601:608	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	0	33	with	films	33:37	arg1	spheres					65:71	food-inspired carbon spheres	44:71	food-inspired carbon spheres	44:71	Antibacterial chitosan composite films with food-inspired carbon spheres immobilized AgNPs.
34144414	5	34	theme	films	859:863	arg1	microstructure					826:839	the microstructure	822:839	the microstructure of chitosan-based films	822:863	Two carbon spheres/AgNPs regulated the microstructure of chitosan-based films because of the electrostatic interaction and the micro-nanometer filling behavior, thus further immobilized the AgNPs.
34144414	7	35	theme	antibacterial	1153:1165	arg1	agent					1167:1171	AgNPs antibacterial agent	1147:1171	AgNPs antibacterial agent	1147:1171	These results will provide a theoretical basis for the green and safe design of AgNPs antibacterial agent.
34144414	5	36	theme	filling	930:936	arg1	behavior					938:945	the micro-nanometer filling behavior	910:945	the micro-nanometer filling behavior	910:945	Two carbon spheres/AgNPs regulated the microstructure of chitosan-based films because of the electrostatic interaction and the micro-nanometer filling behavior, thus further immobilized the AgNPs.
34144414	0	37	theme	carbon	58:63	arg1	spheres					65:71	food-inspired carbon spheres	44:71	food-inspired carbon spheres	44:71	Antibacterial chitosan composite films with food-inspired carbon spheres immobilized AgNPs.
34144414	3	38	theme	fruit-like	484:493	arg1	SMCS-Ag					495:501	dragon fruit-like SMCS-Ag	477:501	dragon fruit-like SMCS-Ag	477:501	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	3	39	theme	high	540:543	arg1	efficiency					560:569	high immobilization efficiency	540:569	high immobilization efficiency for AgNPs	540:579	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	4	40	theme	chitosan-based	765:778	arg1	films					780:784	chitosan-based films	765:784	chitosan-based films	765:784	Subsequently, they were added into chitosan separately to prepare chitosan-based films.
34144414	6	41	theme	excellent	1049:1057	arg1	safety					1059:1064	excellent safety	1049:1064	excellent safety	1049:1064	Importantly, the films presented good antibacterial activity and excellent safety.
34144414	3	42	theme	carbonized	318:327	arg1	methods					329:335	green hydrothermal carbonized methods	299:335	green hydrothermal carbonized methods	299:335	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	3	43	theme	Ag	607:608	arg1	%					658:658	only about 5.63%	643:658	only about 5.63%	643:658	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	3	43	theme	Ag	607:608	arg1	release					590:596	the release	586:596	the release of total Ag from AgNPs-SMCS and SMCS-Ag	586:636	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	3	44	theme	good	521:524	arg1	stability					526:534	good stability	521:534	good stability	521:534	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	3	45	theme	methods	329:335	arg1	kinds					290:294	two kinds	286:294	two kinds of green hydrothermal carbonized methods	286:335	Here, two kinds of green hydrothermal carbonized methods were used to treat sulfhydryl-modified chitosan to obtain two kinds of carbon spheres/AgNPs (Glutinous rice sesameballs-like AgNPs-SMCS and dragon fruit-like SMCS-Ag), which exhibited good stability and high immobilization efficiency for AgNPs, and the release of total Ag from AgNPs-SMCS and SMCS-Ag were only about 5.63% and 3.59% after 14 days, respectively.
34144414	1	46	theme	food	158:161	arg1	packaging					163:171	food packaging	158:171	food packaging	158:171	The cumulative toxicity of AgNPs has limited their application in food packaging.
31935676	3	0	theme	acid	644:647	arg1	groups					660:665	above-mentioned acid functional groups	628:665	above-mentioned acid functional groups	628:665	The Fourier transform infrared analysis confirmed the presence of above-mentioned acid functional groups on MNPs.
31935676	9	1	theme	Fe3O4-MNPs	1391:1400	arg1	@					1404:1404	Fe3O4-MNPs@Si@	1391:1404	Fe3O4-MNPs@Si@AS (45%)	1391:1412	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	9	1	theme	Fe3O4-MNPs	1391:1400	arg1	%					1411:1411	45%	1409:1411	45%	1409:1411	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	2	2	theme	@	547:547	arg1	SO3H					548:551	Fe3O4-MNPs@Si@SO3H	534:551	Fe3O4-MNPs@Si@SO3H	534:551	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	2	theme	@	547:547	arg1	acid					528:531	sulphonic acid	518:531	sulphonic acid (Fe3O4-MNPs@Si@SO3H)	518:552	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	1	3	theme	present	105:111	arg1	study					113:117	The present study	101:117	The present study	101:117	The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose.
31935676	6	4	used	used	1000:1003	arg2	reaction					1016:1023	a model reaction	1008:1023	a model reaction	1008:1023	Cellobiose hydrolysis was used as a model reaction to evaluate the catalytic efficacy of acid-functionalised nanoparticles.
31935676	6	4	used	used	1000:1003	arg2	hydrolysis					985:994	Cellobiose hydrolysis	974:994	Cellobiose hydrolysis	974:994	Cellobiose hydrolysis was used as a model reaction to evaluate the catalytic efficacy of acid-functionalised nanoparticles.
31935676	9	5	theme	Si	1402:1403	arg1	@					1404:1404	Fe3O4-MNPs@Si@	1391:1404	Fe3O4-MNPs@Si@AS (45%)	1391:1412	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	9	5	theme	Si	1402:1403	arg1	%					1411:1411	45%	1409:1411	45%	1409:1411	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	4	6	theme	MNPs	825:828	arg1	nature					789:794	crystalline nature	777:794	crystalline nature	777:794	Similarly, X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis confirmed the crystalline nature and elemental composition of MNPs, respectively.
31935676	4	6	theme	MNPs	825:828	arg1	composition					810:820	elemental composition	800:820	elemental composition	800:820	Similarly, X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis confirmed the crystalline nature and elemental composition of MNPs, respectively.
31935676	7	7	theme	74.8	1108:1111	arg1	%					1112:1112	%	1112:1112	%	1112:1112	A maximum 74.8% cellobiose conversion was reported in case of Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis.
31935676	7	8	theme	@	1173:1173	arg1	SO3H					1174:1177	Fe3O4-MNPs@Si@SO3H	1160:1177	Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis	1160:1206	A maximum 74.8% cellobiose conversion was reported in case of Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis.
31935676	5	9	theme	TEM	845:847	arg1	micrographs					849:859	TEM micrographs	845:859	TEM micrographs	845:859	TEM micrographs showed the synthesis of spherical and polydispersed nanoparticles having diameter size in the range of 20-80 nm.
31935676	8	10	theme	acid-functionalised	1229:1247	arg1	MNPs					1249:1252	thus used acid-functionalised MNPs	1219:1252	thus used acid-functionalised MNPs	1219:1252	Moreover, thus used acid-functionalised MNPs were magnetically separated and reused.
31935676	10	11	theme	third	1496:1500	arg1	cycle					1502:1506	third cycle	1496:1506	third cycle of hydrolysis	1496:1520	However, similar pattern was reported in case of third cycle of hydrolysis.
31935676	1	12	theme	evaluation	221:230	arg1	preparation					136:146	the preparation	132:146	the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose	132:287	The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose.
31935676	3	13	attach	presence	616:623	arg1	MNPs					670:673	MNPs	670:673	MNPs	670:673	The Fourier transform infrared analysis confirmed the presence of above-mentioned acid functional groups on MNPs.
31935676	3	13	attach	presence	616:623	arg2	groups					660:665	above-mentioned acid functional groups	628:665	above-mentioned acid functional groups	628:665	The Fourier transform infrared analysis confirmed the presence of above-mentioned acid functional groups on MNPs.
31935676	2	14	theme	sulphonic	518:526	arg1	SO3H					548:551	Fe3O4-MNPs@Si@SO3H	534:551	Fe3O4-MNPs@Si@SO3H	534:551	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	14	theme	sulphonic	518:526	arg1	acid					528:531	sulphonic acid	518:531	sulphonic acid (Fe3O4-MNPs@Si@SO3H)	518:552	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	9	15	theme	Si	1429:1430	arg1	BCOOH					1432:1436	Fe3O4-MNPs@Si@BCOOH	1418:1436	Fe3O4-MNPs@Si@BCOOH (18.3%)	1418:1444	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	9	15	theme	Si	1429:1430	arg1	%					1443:1443	18.3%	1439:1443	18.3%	1439:1443	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	7	16	theme	Fe3O4-MNPs	1160:1169	arg1	SO3H					1174:1177	Fe3O4-MNPs@Si@SO3H	1160:1177	Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis	1160:1206	A maximum 74.8% cellobiose conversion was reported in case of Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis.
31935676	3	17	dep	Fourier	566:572	arg1	transform					574:582	transform	574:582	transform infrared analysis	574:600	The Fourier transform infrared analysis confirmed the presence of above-mentioned acid functional groups on MNPs.
31935676	2	18	theme	@	544:544	arg1	SO3H					548:551	Fe3O4-MNPs@Si@SO3H	534:551	Fe3O4-MNPs@Si@SO3H	534:551	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	18	theme	@	544:544	arg1	acid					528:531	sulphonic acid	518:531	sulphonic acid (Fe3O4-MNPs@Si@SO3H)	518:552	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	5	19	theme	polydispersed	899:911	arg1	nanoparticles					913:925	spherical and polydispersed nanoparticles	885:925	spherical and polydispersed nanoparticles having diameter size in the range of 20-80 nm	885:971	TEM micrographs showed the synthesis of spherical and polydispersed nanoparticles having diameter size in the range of 20-80 nm.
31935676	12	20	theme	acid-functionalised	1603:1621	arg1	MNPs					1623:1626	acid-functionalised MNPs	1603:1626	acid-functionalised MNPs	1603:1626	Moreover, reuse of acid-functionalised MNPs makes the process economically viable.
31935676	1	21	theme	different	157:165	arg1	MNPs					211:214	MNPs	211:214	MNPs	211:214	The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose.
31935676	1	21	theme	different	157:165	arg1	nanoparticles					196:208	three different acid-functionalised magnetic nanoparticles	151:208	three different acid-functionalised magnetic nanoparticles (MNPs)	151:215	The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose.
31935676	5	22	theme	nanoparticles	913:925	arg1	synthesis					872:880	the synthesis	868:880	the synthesis of spherical and polydispersed nanoparticles having diameter size in the range of 20-80 nm	868:971	TEM micrographs showed the synthesis of spherical and polydispersed nanoparticles having diameter size in the range of 20-80 nm.
31935676	9	23	theme	Fe3O4-MNPs	1418:1427	arg1	BCOOH					1432:1436	Fe3O4-MNPs@Si@BCOOH	1418:1436	Fe3O4-MNPs@Si@BCOOH (18.3%)	1418:1444	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	9	23	theme	Fe3O4-MNPs	1418:1427	arg1	%					1443:1443	18.3%	1439:1443	18.3%	1439:1443	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	0	24	theme	magnetic	77:84	arg1	nanoparticles					86:98	different acid-functionalised Fe3O4 magnetic nanoparticles	41:98	different acid-functionalised Fe3O4 magnetic nanoparticles	41:98	Catalytic hydrolysis of cellobiose using different acid-functionalised Fe3O4 magnetic nanoparticles.
31935676	1	25	theme	magnetic	187:194	arg1	MNPs					211:214	MNPs	211:214	MNPs	211:214	The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose.
31935676	1	25	theme	magnetic	187:194	arg1	nanoparticles					196:208	three different acid-functionalised magnetic nanoparticles	151:208	three different acid-functionalised magnetic nanoparticles (MNPs)	151:215	The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose.
31935676	2	26	theme	butylcarboxylic	471:485	arg1	acid					487:490	butylcarboxylic acid	471:490	butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH)	471:512	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	26	theme	butylcarboxylic	471:485	arg1	BCOOH					507:511	Fe3O4-MNPs@Si@BCOOH	493:511	Fe3O4-MNPs@Si@BCOOH	493:511	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	7	27	theme	hydrolysis	1197:1206	arg1	cycle					1188:1192	first cycle	1182:1192	first cycle of hydrolysis	1182:1206	A maximum 74.8% cellobiose conversion was reported in case of Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis.
31935676	5	28	theme	spherical	885:893	arg1	nanoparticles					913:925	spherical and polydispersed nanoparticles	885:925	spherical and polydispersed nanoparticles having diameter size in the range of 20-80 nm	885:971	TEM micrographs showed the synthesis of spherical and polydispersed nanoparticles having diameter size in the range of 20-80 nm.
31935676	2	29	theme	@	506:506	arg1	acid					487:490	butylcarboxylic acid	471:490	butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH)	471:512	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	29	theme	@	506:506	arg1	BCOOH					507:511	Fe3O4-MNPs@Si@BCOOH	493:511	Fe3O4-MNPs@Si@BCOOH	493:511	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	4	30	theme	dispersive	724:733	arg1	spectroscopy					741:752	energy dispersive X-ray spectroscopy	717:752	energy dispersive X-ray spectroscopy	717:752	Similarly, X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis confirmed the crystalline nature and elemental composition of MNPs, respectively.
31935676	9	31	theme	second	1297:1302	arg1	cycle					1304:1308	second cycle	1297:1308	second cycle of hydrolysis	1297:1322	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	6	32	theme	Cellobiose	974:983	arg1	hydrolysis					985:994	Cellobiose hydrolysis	974:994	Cellobiose hydrolysis	974:994	Cellobiose hydrolysis was used as a model reaction to evaluate the catalytic efficacy of acid-functionalised nanoparticles.
31935676	6	32	theme	Cellobiose	974:983	arg1	reaction					1016:1023	a model reaction	1008:1023	a model reaction	1008:1023	Cellobiose hydrolysis was used as a model reaction to evaluate the catalytic efficacy of acid-functionalised nanoparticles.
31935676	2	33	theme	@	503:503	arg1	acid					487:490	butylcarboxylic acid	471:490	butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH)	471:512	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	33	theme	@	503:503	arg1	BCOOH					507:511	Fe3O4-MNPs@Si@BCOOH	493:511	Fe3O4-MNPs@Si@BCOOH	493:511	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	4	34	theme	spectroscopy	741:752	arg1	analysis					754:761	X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis	687:761	X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis	687:761	Similarly, X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis confirmed the crystalline nature and elemental composition of MNPs, respectively.
31935676	2	35	dep	acid	446:449	arg1	@					465:465	Fe3O4-MNPs@Si@	452:465	Fe3O4-MNPs@Si@AS	452:467	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	35	dep	acid	446:449	arg1	groups					554:559	groups	554:559	groups	554:559	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	6	36	theme	model	1010:1014	arg1	hydrolysis					985:994	Cellobiose hydrolysis	974:994	Cellobiose hydrolysis	974:994	Cellobiose hydrolysis was used as a model reaction to evaluate the catalytic efficacy of acid-functionalised nanoparticles.
31935676	6	36	theme	model	1010:1014	arg1	reaction					1016:1023	a model reaction	1008:1023	a model reaction	1008:1023	Cellobiose hydrolysis was used as a model reaction to evaluate the catalytic efficacy of acid-functionalised nanoparticles.
31935676	6	37	theme	acid-functionalised	1063:1081	arg1	nanoparticles					1083:1095	acid-functionalised nanoparticles	1063:1095	acid-functionalised nanoparticles	1063:1095	Cellobiose hydrolysis was used as a model reaction to evaluate the catalytic efficacy of acid-functionalised nanoparticles.
31935676	2	38	theme	@	462:462	arg1	@					465:465	Fe3O4-MNPs@Si@	452:465	Fe3O4-MNPs@Si@AS	452:467	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	4	39	theme	diffraction	693:703	arg1	pattern					705:711	X-ray diffraction pattern	687:711	X-ray diffraction pattern	687:711	Similarly, X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis confirmed the crystalline nature and elemental composition of MNPs, respectively.
31935676	2	40	theme	@	403:403	arg1	Si					404:405	Fe3O4-MNPs@Si	393:405	Fe3O4-MNPs@Si	393:405	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	40	theme	@	403:403	arg1	coating					384:390	silica coating	377:390	silica coating (Fe3O4-MNPs@Si)	377:406	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	0	41	theme	Catalytic	0:8	arg1	hydrolysis					10:19	Catalytic hydrolysis	0:19	Catalytic hydrolysis of cellobiose	0:33	Catalytic hydrolysis of cellobiose using different acid-functionalised Fe3O4 magnetic nanoparticles.
31935676	9	42	dep	%	1411:1411	arg1	AS					1405:1406	AS	1405:1406	AS	1405:1406	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	2	43	theme	alkylsulfonic	432:444	arg1	acid					446:449	alkylsulfonic acid	432:449	alkylsulfonic acid (Fe3O4-MNPs@Si@AS)	432:468	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	7	44	theme	@	1170:1170	arg1	SO3H					1174:1177	Fe3O4-MNPs@Si@SO3H	1160:1177	Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis	1160:1206	A maximum 74.8% cellobiose conversion was reported in case of Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis.
31935676	9	45	theme	@	1335:1335	arg1	SO3H					1339:1342	Fe3O4-MNPs@Si@SO3H	1325:1342	Fe3O4-MNPs@Si@SO3H	1325:1342	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	9	46	theme	@	1338:1338	arg1	SO3H					1339:1342	Fe3O4-MNPs@Si@SO3H	1325:1342	Fe3O4-MNPs@Si@SO3H	1325:1342	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	0	47	theme	acid-functionalised	51:69	arg1	nanoparticles					86:98	different acid-functionalised Fe3O4 magnetic nanoparticles	41:98	different acid-functionalised Fe3O4 magnetic nanoparticles	41:98	Catalytic hydrolysis of cellobiose using different acid-functionalised Fe3O4 magnetic nanoparticles.
31935676	3	48	theme	above-mentioned	628:642	arg1	groups					660:665	above-mentioned acid functional groups	628:665	above-mentioned acid functional groups	628:665	The Fourier transform infrared analysis confirmed the presence of above-mentioned acid functional groups on MNPs.
31935676	3	49	dep	transform	574:582	arg1	infrared					584:591	infrared	584:591	transform infrared analysis	574:600	The Fourier transform infrared analysis confirmed the presence of above-mentioned acid functional groups on MNPs.
31935676	2	50	theme	oxide	306:310	arg1	MNPs					319:322	iron oxide (Fe3O4)MNPs	301:322	iron oxide (Fe3O4)MNPs	301:322	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	10	51	theme	similar	1456:1462	arg1	pattern					1464:1470	similar pattern	1456:1470	similar pattern	1456:1470	However, similar pattern was reported in case of third cycle of hydrolysis.
31935676	4	52	theme	crystalline	777:787	arg1	nature					789:794	crystalline nature	777:794	crystalline nature	777:794	Similarly, X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis confirmed the crystalline nature and elemental composition of MNPs, respectively.
31935676	2	53	theme	silica	377:382	arg1	Si					404:405	Fe3O4-MNPs@Si	393:405	Fe3O4-MNPs@Si	393:405	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	53	theme	silica	377:382	arg1	coating					384:390	silica coating	377:390	silica coating (Fe3O4-MNPs@Si)	377:406	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	3	54	theme	functional	649:658	arg1	groups					660:665	above-mentioned acid functional groups	628:665	above-mentioned acid functional groups	628:665	The Fourier transform infrared analysis confirmed the presence of above-mentioned acid functional groups on MNPs.
31935676	7	55	theme	%	1112:1112	arg1	conversion					1125:1134	A maximum 74.8% cellobiose conversion	1098:1134	A maximum 74.8% cellobiose conversion	1098:1134	A maximum 74.8% cellobiose conversion was reported in case of Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis.
31935676	9	56	theme	@	1401:1401	arg1	@					1404:1404	Fe3O4-MNPs@Si@	1391:1404	Fe3O4-MNPs@Si@AS (45%)	1391:1412	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	9	56	theme	@	1401:1401	arg1	%					1411:1411	45%	1409:1411	45%	1409:1411	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	2	57	theme	Si	545:546	arg1	SO3H					548:551	Fe3O4-MNPs@Si@SO3H	534:551	Fe3O4-MNPs@Si@SO3H	534:551	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	57	theme	Si	545:546	arg1	acid					528:531	sulphonic acid	518:531	sulphonic acid (Fe3O4-MNPs@Si@SO3H)	518:552	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	7	58	theme	maximum	1100:1106	arg1	conversion					1125:1134	A maximum 74.8% cellobiose conversion	1098:1134	A maximum 74.8% cellobiose conversion	1098:1134	A maximum 74.8% cellobiose conversion was reported in case of Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis.
31935676	12	59	theme	viable	1659:1664	arg1	process					1638:1644	the process	1634:1644	the process economically viable	1634:1664	Moreover, reuse of acid-functionalised MNPs makes the process economically viable.
31935676	11	60	theme	proposed	1527:1534	arg1	approach					1536:1543	The proposed approach	1523:1543	The proposed approach	1523:1543	The proposed approach is considered as rapid and convenient.
31935676	8	61	theme	used	1224:1227	arg1	MNPs					1249:1252	thus used acid-functionalised MNPs	1219:1252	thus used acid-functionalised MNPs	1219:1252	Moreover, thus used acid-functionalised MNPs were magnetically separated and reused.
31935676	7	62	from	SO3H	1174:1177	arg1	cycle					1188:1192	first cycle	1182:1192	first cycle of hydrolysis	1182:1206	A maximum 74.8% cellobiose conversion was reported in case of Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis.
31935676	1	63	theme	catalytic	242:250	arg1	efficacy					252:259	their catalytic efficacy	236:259	their catalytic efficacy in hydrolysis of cellobiose	236:287	The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose.
31935676	5	64	contain	having	927:932	arg1	nanoparticles					913:925	spherical and polydispersed nanoparticles	885:925	spherical and polydispersed nanoparticles having diameter size in the range of 20-80 nm	885:971	TEM micrographs showed the synthesis of spherical and polydispersed nanoparticles having diameter size in the range of 20-80 nm.
31935676	5	64	contain	having	927:932	arg2	size					943:946	diameter size	934:946	diameter size	934:946	TEM micrographs showed the synthesis of spherical and polydispersed nanoparticles having diameter size in the range of 20-80 nm.
31935676	10	65	theme	hydrolysis	1511:1520	arg1	cycle					1502:1506	third cycle	1496:1506	third cycle of hydrolysis	1496:1520	However, similar pattern was reported in case of third cycle of hydrolysis.
31935676	1	66	from	efficacy	252:259	arg1	hydrolysis					264:273	hydrolysis	264:273	hydrolysis of cellobiose	264:287	The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose.
31935676	9	67	theme	@	1428:1428	arg1	BCOOH					1432:1436	Fe3O4-MNPs@Si@BCOOH	1418:1436	Fe3O4-MNPs@Si@BCOOH (18.3%)	1418:1444	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	9	67	theme	@	1428:1428	arg1	%					1443:1443	18.3%	1439:1443	18.3%	1439:1443	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	2	68	theme	Fe3O4-MNPs	534:543	arg1	SO3H					548:551	Fe3O4-MNPs@Si@SO3H	534:551	Fe3O4-MNPs@Si@SO3H	534:551	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	68	theme	Fe3O4-MNPs	534:543	arg1	acid					528:531	sulphonic acid	518:531	sulphonic acid (Fe3O4-MNPs@Si@SO3H)	518:552	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	69	theme	iron	301:304	arg1	Fe3O4					313:317	Fe3O4	313:317	Fe3O4	313:317	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	69	theme	iron	301:304	arg1	oxide					306:310	iron oxide	301:310	iron oxide (Fe3O4)MNPs	301:322	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	9	70	theme	@	1431:1431	arg1	BCOOH					1432:1436	Fe3O4-MNPs@Si@BCOOH	1418:1436	Fe3O4-MNPs@Si@BCOOH (18.3%)	1418:1444	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	9	70	theme	@	1431:1431	arg1	%					1443:1443	18.3%	1439:1443	18.3%	1439:1443	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	2	71	dep	synthesised	329:339	arg1	modified					356:363	modified	356:363	further modified by applying silica coating (Fe3O4-MNPs@Si)	348:406	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	71	dep	synthesised	329:339	arg1	functionalised					412:425	functionalised	412:425	functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups	412:559	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	1	72	theme	acid-functionalised	167:185	arg1	MNPs					211:214	MNPs	211:214	MNPs	211:214	The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose.
31935676	1	72	theme	acid-functionalised	167:185	arg1	nanoparticles					196:208	three different acid-functionalised magnetic nanoparticles	151:208	three different acid-functionalised magnetic nanoparticles (MNPs)	151:215	The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose.
31935676	12	73	theme	MNPs	1623:1626	arg1	reuse					1594:1598	reuse	1594:1598	reuse of acid-functionalised MNPs	1594:1626	Moreover, reuse of acid-functionalised MNPs makes the process economically viable.
31935676	9	74	theme	%	1355:1355	arg1	conversion					1368:1377	49.8% cellobiose conversion	1351:1377	49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%)	1351:1444	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	1	75	theme	nanoparticles	196:208	arg1	preparation					136:146	the preparation	132:146	the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose	132:287	The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose.
31935676	7	76	theme	cellobiose	1114:1123	arg1	conversion					1125:1134	A maximum 74.8% cellobiose conversion	1098:1134	A maximum 74.8% cellobiose conversion	1098:1134	A maximum 74.8% cellobiose conversion was reported in case of Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis.
31935676	7	77	theme	first	1182:1186	arg1	cycle					1188:1192	first cycle	1182:1192	first cycle of hydrolysis	1182:1206	A maximum 74.8% cellobiose conversion was reported in case of Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis.
31935676	2	78	theme	Si	504:505	arg1	acid					487:490	butylcarboxylic acid	471:490	butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH)	471:512	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	78	theme	Si	504:505	arg1	BCOOH					507:511	Fe3O4-MNPs@Si@BCOOH	493:511	Fe3O4-MNPs@Si@BCOOH	493:511	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	4	79	theme	energy	717:722	arg1	spectroscopy					741:752	energy dispersive X-ray spectroscopy	717:752	energy dispersive X-ray spectroscopy	717:752	Similarly, X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis confirmed the crystalline nature and elemental composition of MNPs, respectively.
31935676	5	80	theme	20-80 nm	964:971	arg1	range					955:959	the range	951:959	the range of 20-80 nm	951:971	TEM micrographs showed the synthesis of spherical and polydispersed nanoparticles having diameter size in the range of 20-80 nm.
31935676	6	81	theme	nanoparticles	1083:1095	arg1	efficacy					1051:1058	the catalytic efficacy	1037:1058	the catalytic efficacy of acid-functionalised nanoparticles	1037:1095	Cellobiose hydrolysis was used as a model reaction to evaluate the catalytic efficacy of acid-functionalised nanoparticles.
31935676	2	82	theme	Fe3O4-MNPs	493:502	arg1	acid					487:490	butylcarboxylic acid	471:490	butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH)	471:512	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	82	theme	Fe3O4-MNPs	493:502	arg1	BCOOH					507:511	Fe3O4-MNPs@Si@BCOOH	493:511	Fe3O4-MNPs@Si@BCOOH	493:511	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	4	83	theme	X-ray	735:739	arg1	spectroscopy					741:752	energy dispersive X-ray spectroscopy	717:752	energy dispersive X-ray spectroscopy	717:752	Similarly, X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis confirmed the crystalline nature and elemental composition of MNPs, respectively.
31935676	7	84	theme	Si	1171:1172	arg1	SO3H					1174:1177	Fe3O4-MNPs@Si@SO3H	1160:1177	Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis	1160:1206	A maximum 74.8% cellobiose conversion was reported in case of Fe3O4-MNPs@Si@SO3H in first cycle of hydrolysis.
31935676	9	85	theme	hydrolysis	1313:1322	arg1	cycle					1304:1308	second cycle	1297:1308	second cycle of hydrolysis	1297:1322	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	5	86	theme	diameter	934:941	arg1	size					943:946	diameter size	934:946	diameter size	934:946	TEM micrographs showed the synthesis of spherical and polydispersed nanoparticles having diameter size in the range of 20-80 nm.
31935676	2	87	theme	Fe3O4-MNPs	452:461	arg1	@					465:465	Fe3O4-MNPs@Si@	452:465	Fe3O4-MNPs@Si@AS	452:467	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	4	88	theme	X-ray	687:691	arg1	pattern					705:711	X-ray diffraction pattern	687:711	X-ray diffraction pattern	687:711	Similarly, X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis confirmed the crystalline nature and elemental composition of MNPs, respectively.
31935676	2	89	theme	Fe3O4-MNPs	393:402	arg1	Si					404:405	Fe3O4-MNPs@Si	393:405	Fe3O4-MNPs@Si	393:405	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	2	89	theme	Fe3O4-MNPs	393:402	arg1	coating					384:390	silica coating	377:390	silica coating (Fe3O4-MNPs@Si)	377:406	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	0	90	theme	cellobiose	24:33	arg1	hydrolysis					10:19	Catalytic hydrolysis	0:19	Catalytic hydrolysis of cellobiose	0:33	Catalytic hydrolysis of cellobiose using different acid-functionalised Fe3O4 magnetic nanoparticles.
31935676	9	91	theme	Fe3O4-MNPs	1325:1334	arg1	SO3H					1339:1342	Fe3O4-MNPs@Si@SO3H	1325:1342	Fe3O4-MNPs@Si@SO3H	1325:1342	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	6	92	theme	catalytic	1041:1049	arg1	efficacy					1051:1058	the catalytic efficacy	1037:1058	the catalytic efficacy of acid-functionalised nanoparticles	1037:1095	Cellobiose hydrolysis was used as a model reaction to evaluate the catalytic efficacy of acid-functionalised nanoparticles.
31935676	4	93	theme	pattern	705:711	arg1	analysis					754:761	X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis	687:761	X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis	687:761	Similarly, X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis confirmed the crystalline nature and elemental composition of MNPs, respectively.
31935676	0	94	theme	different	41:49	arg1	nanoparticles					86:98	different acid-functionalised Fe3O4 magnetic nanoparticles	41:98	different acid-functionalised Fe3O4 magnetic nanoparticles	41:98	Catalytic hydrolysis of cellobiose using different acid-functionalised Fe3O4 magnetic nanoparticles.
31935676	9	95	theme	Si	1336:1337	arg1	SO3H					1339:1342	Fe3O4-MNPs@Si@SO3H	1325:1342	Fe3O4-MNPs@Si@SO3H	1325:1342	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	0	96	theme	Fe3O4	71:75	arg1	nanoparticles					86:98	different acid-functionalised Fe3O4 magnetic nanoparticles	41:98	different acid-functionalised Fe3O4 magnetic nanoparticles	41:98	Catalytic hydrolysis of cellobiose using different acid-functionalised Fe3O4 magnetic nanoparticles.
31935676	2	97	theme	Si	463:464	arg1	@					465:465	Fe3O4-MNPs@Si@	452:465	Fe3O4-MNPs@Si@AS	452:467	Initially, iron oxide (Fe3O4)MNPs were synthesised, which further modified by applying silica coating (Fe3O4-MNPs@Si) and functionalised with alkylsulfonic acid (Fe3O4-MNPs@Si@AS), butylcarboxylic acid (Fe3O4-MNPs@Si@BCOOH) and sulphonic acid (Fe3O4-MNPs@Si@SO3H) groups.
31935676	4	98	theme	elemental	800:808	arg1	composition					810:820	elemental composition	800:820	elemental composition	800:820	Similarly, X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis confirmed the crystalline nature and elemental composition of MNPs, respectively.
31935676	9	99	theme	49.8	1351:1354	arg1	%					1355:1355	%	1355:1355	%	1355:1355	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	9	100	theme	cellobiose	1357:1366	arg1	conversion					1368:1377	49.8% cellobiose conversion	1351:1377	49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%)	1351:1444	In second cycle of hydrolysis, Fe3O4-MNPs@Si@SO3H showed 49.8% cellobiose conversion followed by Fe3O4-MNPs@Si@AS (45%) and Fe3O4-MNPs@Si@BCOOH (18.3%).
31935676	4	101	dep	nature	789:794	arg1	the					773:775	the	773:775	the	773:775	Similarly, X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis confirmed the crystalline nature and elemental composition of MNPs, respectively.
31935676	3	102	from	presence	616:623	arg1	MNPs					670:673	MNPs	670:673	MNPs	670:673	The Fourier transform infrared analysis confirmed the presence of above-mentioned acid functional groups on MNPs.
31935676	3	103	theme	groups	660:665	arg1	presence					616:623	the presence	612:623	the presence of above-mentioned acid functional groups on MNPs	612:673	The Fourier transform infrared analysis confirmed the presence of above-mentioned acid functional groups on MNPs.
31935676	1	104	theme	cellobiose	278:287	arg1	hydrolysis					264:273	hydrolysis	264:273	hydrolysis of cellobiose	264:287	The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose.
34641480	1	0	theme	sustained	269:277	arg1	release					291:297	sustained paracetamol release	269:297	sustained paracetamol release	269:297	The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release.
34641480	2	1	theme	TEOS	310:313	arg1	percentages					315:325	Different TEOS percentages	300:325	Different TEOS percentages	300:325	Different TEOS percentages were used because of their nontoxic behavior to study newly designed hydrogels' crosslinking and physicochemical properties.
34641480	4	2	theme	different	703:711	arg1	media					713:717	different media	703:717	different media	703:717	The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media.
34641480	10	3	theme	Gram-positive	1623:1635	arg1	strains					1755:1761	Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains	1623:1761	Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains	1623:1761	The antimicrobial analysis revealed that these hydrogels are highly antibacterial against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains.
34641480	9	4	theme	decreased	1472:1480	arg1	pressure					1490:1497	decreased osmotic pressure	1472:1497	decreased osmotic pressure in various electrolyte solutions	1472:1530	These hydrogels demonstrated that, as the ionic concentration was increased, swelling decreased due to decreased osmotic pressure in various electrolyte solutions.
34641480	4	5	from	analysis	691:698	arg1	PBS					735:737	PBS	735:737	PBS	735:737	The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media.
34641480	4	5	from	analysis	691:698	arg1	media					713:717	different media	703:717	different media	703:717	The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media.
34641480	1	6	theme	blended	207:213	arg1	hydrogel					215:222	CS/PVA/GG blended hydrogel	197:222	CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS)	197:263	The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release.
34641480	10	7	dep	Gram-positive	1623:1635	arg1	cereus					1673:1678	Bacillus cereus	1664:1678	Bacillus cereus	1664:1678	The antimicrobial analysis revealed that these hydrogels are highly antibacterial against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains.
34641480	10	7	dep	Gram-positive	1623:1635	arg1	aeruginosa					1712:1721	Pseudomonas aeruginosa	1700:1721	Pseudomonas aeruginosa	1700:1721	The antimicrobial analysis revealed that these hydrogels are highly antibacterial against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains.
34641480	10	7	dep	Gram-positive	1623:1635	arg1	coli					1739:1742	Escherichia coli	1727:1742	Escherichia coli	1727:1742	The antimicrobial analysis revealed that these hydrogels are highly antibacterial against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains.
34641480	10	7	dep	Gram-positive	1623:1635	arg1	aureus					1653:1658	Staphylococcus aureus	1638:1658	Staphylococcus aureus	1638:1658	The antimicrobial analysis revealed that these hydrogels are highly antibacterial against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains.
34641480	9	8	theme	various	1502:1508	arg1	solutions					1522:1530	various electrolyte solutions	1502:1530	various electrolyte solutions	1502:1530	These hydrogels demonstrated that, as the ionic concentration was increased, swelling decreased due to decreased osmotic pressure in various electrolyte solutions.
34641480	1	9	theme	present	137:143	arg1	research					145:152	The present research	133:152	The present research	133:152	The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release.
34641480	12	10	dep	models	1965:1970	arg1	such					1973:1976	such	1973:1976	such	1973:1976	To analyze drug release behaviour, the drug release kinetics was assessed against different mathematical models (such as zero and first order, Higuchi, Baker-Lonsdale, Hixson, and Peppas).
34641480	1	11	theme	tetra	238:242	arg1	TEOS					259:262	TEOS	259:262	TEOS	259:262	The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release.
34641480	1	11	theme	tetra	238:242	arg1	orthosilicate					244:256	nontoxic tetra orthosilicate	229:256	nontoxic tetra orthosilicate (TEOS)	229:263	The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release.
34641480	13	12	dep	=	2149:2149	arg1	0.98509					2151:2157	0.98509	2151:2157	0.98509	2151:2157	It was found that hydrogel (CPG2) follows the Peppas model with the highest value of regression (R2 = 0.98509).
34641480	4	13	theme	drug	744:747	arg1	kinetics					757:764	drug release kinetics	744:764	drug release kinetics	744:764	The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media.
34641480	5	14	theme	wetting	971:977	arg1	behavior					979:986	different surface and wetting behavior	949:986	behavior	979:986	The FTIR analysis confirmed the components added and crosslinking between them, and surface morphology confirmed different surface and wetting behavior due to different crosslinking.
34641480	11	15	theme	buffer	1812:1817	arg1	PBS					1827:1829	PBS	1827:1829	PBS	1827:1829	The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min.
34641480	11	15	theme	buffer	1812:1817	arg1	saline					1819:1824	phosphate buffer saline	1802:1824	phosphate buffer saline (PBS) media	1802:1836	The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min.
34641480	5	16	theme	due	988:990	arg1	surface					959:965	different surface and wetting behavior	949:986	surface	959:965	The FTIR analysis confirmed the components added and crosslinking between them, and surface morphology confirmed different surface and wetting behavior due to different crosslinking.
34641480	10	17	theme	antimicrobial	1537:1549	arg1	analysis					1551:1558	The antimicrobial analysis	1533:1558	The antimicrobial analysis	1533:1558	The antimicrobial analysis revealed that these hydrogels are highly antibacterial against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains.
34641480	8	18	theme	controlled	1344:1353	arg1	release					1360:1366	controlled drug release	1344:1366	controlled drug release	1344:1366	These hydrogels are pH-sensitive and appropriate for controlled drug release.
34641480	0	19	theme	Gum/Polyvinyl	73:85	arg1	Hydrogels					103:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels	15:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing	15:130	Development of Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing.
34641480	13	20	theme	regression	2134:2143	arg1	value					2125:2129	the highest value	2113:2129	the highest value of regression (R2 = 0.98509)	2113:2158	It was found that hydrogel (CPG2) follows the Peppas model with the highest value of regression (R2 = 0.98509).
34641480	14	21	theme	biomedical	2257:2266	arg1	applications					2268:2279	biomedical applications	2257:2279	biomedical applications	2257:2279	Hence, from the results, these hydrogels could be a potential biomaterial for wound dressing in biomedical applications.
34641480	0	22	theme	Blended	95:101	arg1	Hydrogels					103:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels	15:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing	15:130	Development of Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing.
34641480	12	23	theme	different	1942:1950	arg1	models					1965:1970	different mathematical models	1942:1970	different mathematical models (such as zero and first order, Higuchi, Baker-Lonsdale, Hixson, and Peppas)	1942:2046	To analyze drug release behaviour, the drug release kinetics was assessed against different mathematical models (such as zero and first order, Higuchi, Baker-Lonsdale, Hixson, and Peppas).
34641480	1	24	theme	fabrication	170:180	arg1	preparation					182:192	the fabrication preparation	166:192	the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release	166:297	The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release.
34641480	2	25	dep	hydrogels	396:404	arg1	crosslinking					407:418	crosslinking	407:418	crosslinking	407:418	Different TEOS percentages were used because of their nontoxic behavior to study newly designed hydrogels' crosslinking and physicochemical properties.
34641480	2	25	dep	hydrogels	396:404	arg1	properties					440:449	physicochemical properties	424:449	physicochemical properties	424:449	Different TEOS percentages were used because of their nontoxic behavior to study newly designed hydrogels' crosslinking and physicochemical properties.
34641480	2	26	theme	physicochemical	424:438	arg1	properties					440:449	physicochemical properties	424:449	physicochemical properties	424:449	Different TEOS percentages were used because of their nontoxic behavior to study newly designed hydrogels' crosslinking and physicochemical properties.
34641480	14	27	theme	potential	2213:2221	arg1	biomaterial					2223:2233	a potential biomaterial	2211:2233	a potential biomaterial for wound dressing in biomedical applications	2211:2279	Hence, from the results, these hydrogels could be a potential biomaterial for wound dressing in biomedical applications.
34641480	14	27	theme	potential	2213:2221	arg1	hydrogels					2192:2200	these hydrogels	2186:2200	these hydrogels	2186:2200	Hence, from the results, these hydrogels could be a potential biomaterial for wound dressing in biomedical applications.
34641480	1	28	with	hydrogel	215:222	arg1	TEOS					259:262	TEOS	259:262	TEOS	259:262	The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release.
34641480	1	28	with	hydrogel	215:222	arg1	orthosilicate					244:256	nontoxic tetra orthosilicate	229:256	nontoxic tetra orthosilicate (TEOS)	229:263	The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release.
34641480	5	29	theme	different	995:1003	arg1	crosslinking					1005:1016	different crosslinking	995:1016	different crosslinking	995:1016	The FTIR analysis confirmed the components added and crosslinking between them, and surface morphology confirmed different surface and wetting behavior due to different crosslinking.
34641480	0	30	theme	Antibacterial	15:27	arg1	Hydrogels					103:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels	15:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing	15:130	Development of Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing.
34641480	6	31	theme	swelling	1096:1103	arg1	behaviour					1105:1113	the swelling behaviour	1092:1113	the swelling behaviour of hydrogel	1092:1125	In various solvents, including water, buffer, and electrolyte solutions, the swelling behaviour of hydrogel was investigated and observed that TEOS amount caused less hydrogel swelling.
34641480	11	32	theme	release	1773:1779	arg1	mechanism					1781:1789	The drug release mechanism	1764:1789	The drug release mechanism	1764:1789	The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min.
34641480	11	32	theme	release	1773:1779	arg1	%					1797:1797	98%	1795:1797	98%	1795:1797	The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min.
34641480	3	33	theme	infrared	511:518	arg1	spectroscopy					520:531	Fourier-transform infrared spectroscopy	493:531	Fourier-transform infrared spectroscopy (FTIR)	493:538	These hydrogels were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties.
34641480	3	33	theme	infrared	511:518	arg1	FTIR					534:537	FTIR	534:537	FTIR	534:537	These hydrogels were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties.
34641480	0	34	theme	Degradable	30:39	arg1	Hydrogels					103:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels	15:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing	15:130	Development of Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing.
34641480	12	35	theme	drug	1899:1902	arg1	kinetics					1912:1919	the drug release kinetics	1895:1919	the drug release kinetics	1895:1919	To analyze drug release behaviour, the drug release kinetics was assessed against different mathematical models (such as zero and first order, Higuchi, Baker-Lonsdale, Hixson, and Peppas).
34641480	3	36	theme	scanning	541:548	arg1	SEM					571:573	SEM	571:573	SEM	571:573	These hydrogels were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties.
34641480	3	36	theme	scanning	541:548	arg1	microscopy					559:568	scanning electron microscopy	541:568	scanning electron microscopy (SEM)	541:574	These hydrogels were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties.
34641480	5	37	theme	FTIR	840:843	arg1	analysis					845:852	The FTIR analysis	836:852	The FTIR analysis	836:852	The FTIR analysis confirmed the components added and crosslinking between them, and surface morphology confirmed different surface and wetting behavior due to different crosslinking.
34641480	2	38	theme	nontoxic	354:361	arg1	behavior					363:370	their nontoxic behavior	348:370	their nontoxic behavior	348:370	Different TEOS percentages were used because of their nontoxic behavior to study newly designed hydrogels' crosslinking and physicochemical properties.
34641480	9	39	theme	ionic	1411:1415	arg1	concentration					1417:1429	the ionic concentration	1407:1429	the ionic concentration	1407:1429	These hydrogels demonstrated that, as the ionic concentration was increased, swelling decreased due to decreased osmotic pressure in various electrolyte solutions.
34641480	12	40	theme	release	1876:1882	arg1	behaviour					1884:1892	drug release behaviour	1871:1892	drug release behaviour	1871:1892	To analyze drug release behaviour, the drug release kinetics was assessed against different mathematical models (such as zero and first order, Higuchi, Baker-Lonsdale, Hixson, and Peppas).
34641480	3	41	dep	morphology	626:635	arg1	surface					618:624	surface	618:624	surface	618:624	These hydrogels were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties.
34641480	14	42	from	dressing	2245:2252	arg1	applications					2268:2279	biomedical applications	2257:2279	biomedical applications	2257:2279	Hence, from the results, these hydrogels could be a potential biomaterial for wound dressing in biomedical applications.
34641480	4	43	from	degradation	720:730	arg1	PBS					735:737	PBS	735:737	PBS	735:737	The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media.
34641480	4	43	from	degradation	720:730	arg1	media					713:717	different media	703:717	different media	703:717	The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media.
34641480	1	44	theme	paracetamol	279:289	arg1	release					291:297	sustained paracetamol release	269:297	sustained paracetamol release	269:297	The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release.
34641480	5	45	theme	different	949:957	arg1	surface					959:965	different surface and wetting behavior	949:986	surface	959:965	The FTIR analysis confirmed the components added and crosslinking between them, and surface morphology confirmed different surface and wetting behavior due to different crosslinking.
34641480	2	46	theme	Different	300:308	arg1	percentages					315:325	Different TEOS percentages	300:325	Different TEOS percentages	300:325	Different TEOS percentages were used because of their nontoxic behavior to study newly designed hydrogels' crosslinking and physicochemical properties.
34641480	9	47	theme	osmotic	1482:1488	arg1	pressure					1490:1497	decreased osmotic pressure	1472:1497	decreased osmotic pressure in various electrolyte solutions	1472:1530	These hydrogels demonstrated that, as the ionic concentration was increased, swelling decreased due to decreased osmotic pressure in various electrolyte solutions.
34641480	0	48	theme	pH-Responsive	45:57	arg1	Hydrogels					103:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels	15:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing	15:130	Development of Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing.
34641480	11	49	from	pH	1841:1842	arg1	mechanism					1781:1789	The drug release mechanism	1764:1789	The drug release mechanism	1764:1789	The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min.
34641480	11	49	from	pH	1841:1842	arg1	%					1797:1797	98%	1795:1797	98%	1795:1797	The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min.
34641480	3	50	theme	functional	606:615	arg1	properties					666:675	the functional, surface morphology, hydrophilic, or hydrophobic properties	602:675	the functional, surface morphology, hydrophilic, or hydrophobic properties	602:675	These hydrogels were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties.
34641480	1	51	theme	CS/PVA/GG	197:205	arg1	hydrogel					215:222	CS/PVA/GG blended hydrogel	197:222	CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS)	197:263	The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release.
34641480	12	52	theme	first	1990:1994	arg1	order					1996:2000	first order	1990:2000	first order	1990:2000	To analyze drug release behaviour, the drug release kinetics was assessed against different mathematical models (such as zero and first order, Higuchi, Baker-Lonsdale, Hixson, and Peppas).
34641480	7	53	theme	acidic	1208:1213	arg1	pH					1215:1216	acidic pH	1208:1216	acidic pH	1208:1216	In acidic pH, hydrogels swell the most, while they swell the least at pH 7 or higher.
34641480	1	54	theme	hydrogel	215:222	arg1	preparation					182:192	the fabrication preparation	166:192	the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release	166:297	The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release.
34641480	6	55	theme	various	1022:1028	arg1	electrolyte					1069:1079	electrolyte	1069:1079	electrolyte	1069:1079	In various solvents, including water, buffer, and electrolyte solutions, the swelling behaviour of hydrogel was investigated and observed that TEOS amount caused less hydrogel swelling.
34641480	6	55	theme	various	1022:1028	arg1	buffer					1057:1062	buffer	1057:1062	buffer	1057:1062	In various solvents, including water, buffer, and electrolyte solutions, the swelling behaviour of hydrogel was investigated and observed that TEOS amount caused less hydrogel swelling.
34641480	6	55	theme	various	1022:1028	arg1	solvents					1030:1037	various solvents	1022:1037	various solvents	1022:1037	In various solvents, including water, buffer, and electrolyte solutions, the swelling behaviour of hydrogel was investigated and observed that TEOS amount caused less hydrogel swelling.
34641480	6	55	theme	various	1022:1028	arg1	water					1050:1054	water	1050:1054	water	1050:1054	In various solvents, including water, buffer, and electrolyte solutions, the swelling behaviour of hydrogel was investigated and observed that TEOS amount caused less hydrogel swelling.
34641480	5	56	theme	surface	920:926	arg1	morphology					928:937	surface morphology	920:937	surface morphology	920:937	The FTIR analysis confirmed the components added and crosslinking between them, and surface morphology confirmed different surface and wetting behavior due to different crosslinking.
34641480	1	57	theme	nontoxic	229:236	arg1	TEOS					259:262	TEOS	259:262	TEOS	259:262	The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release.
34641480	1	57	theme	nontoxic	229:236	arg1	orthosilicate					244:256	nontoxic tetra orthosilicate	229:256	nontoxic tetra orthosilicate (TEOS)	229:263	The present research is based on the fabrication preparation of CS/PVA/GG blended hydrogel with nontoxic tetra orthosilicate (TEOS) for sustained paracetamol release.
34641480	4	58	theme	swelling	682:689	arg1	analysis					691:698	The swelling analysis	678:698	The swelling analysis in different media	678:717	The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media.
34641480	13	59	theme	highest	2117:2123	arg1	value					2125:2129	the highest value	2113:2129	the highest value of regression (R2 = 0.98509)	2113:2158	It was found that hydrogel (CPG2) follows the Peppas model with the highest value of regression (R2 = 0.98509).
34641480	13	60	dep	regression	2134:2143	arg1	R2					2146:2147	R2	2146:2147	R2 = 0.98509	2146:2157	It was found that hydrogel (CPG2) follows the Peppas model with the highest value of regression (R2 = 0.98509).
34641480	14	61	from	results	2177:2183	arg1	biomaterial					2223:2233	a potential biomaterial	2211:2233	a potential biomaterial for wound dressing in biomedical applications	2211:2279	Hence, from the results, these hydrogels could be a potential biomaterial for wound dressing in biomedical applications.
34641480	14	61	from	results	2177:2183	arg1	hydrogels					2192:2200	these hydrogels	2186:2200	these hydrogels	2186:2200	Hence, from the results, these hydrogels could be a potential biomaterial for wound dressing in biomedical applications.
34641480	4	62	theme	release	749:755	arg1	kinetics					757:764	drug release kinetics	744:764	drug release kinetics	744:764	The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media.
34641480	11	63	theme	saline	1819:1824	arg1	media					1832:1836	phosphate buffer saline (PBS) media	1802:1836	phosphate buffer saline (PBS) media	1802:1836	The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min.
34641480	0	64	theme	Alcohol	87:93	arg1	Hydrogels					103:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels	15:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing	15:130	Development of Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing.
34641480	13	65	theme	Peppas	2095:2100	arg1	model					2102:2106	the Peppas model	2091:2106	the Peppas model	2091:2106	It was found that hydrogel (CPG2) follows the Peppas model with the highest value of regression (R2 = 0.98509).
34641480	6	66	dep	water	1050:1054	arg1	solutions					1081:1089	solutions	1081:1089	solutions	1081:1089	In various solvents, including water, buffer, and electrolyte solutions, the swelling behaviour of hydrogel was investigated and observed that TEOS amount caused less hydrogel swelling.
34641480	11	67	theme	phosphate	1802:1810	arg1	PBS					1827:1829	PBS	1827:1829	PBS	1827:1829	The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min.
34641480	11	67	theme	phosphate	1802:1810	arg1	saline					1819:1824	phosphate buffer saline	1802:1824	phosphate buffer saline (PBS) media	1802:1836	The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min.
34641480	0	68	theme	Hydrogels	103:111	arg1	Development					0:10	Development	0:10	Development of Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing.	0:131	Development of Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing.
34641480	12	69	theme	mathematical	1952:1963	arg1	models					1965:1970	different mathematical models	1942:1970	different mathematical models (such as zero and first order, Higuchi, Baker-Lonsdale, Hixson, and Peppas)	1942:2046	To analyze drug release behaviour, the drug release kinetics was assessed against different mathematical models (such as zero and first order, Higuchi, Baker-Lonsdale, Hixson, and Peppas).
34641480	3	70	dep	functional	606:615	arg1	hydrophilic					638:648	hydrophilic	638:648	hydrophilic	638:648	These hydrogels were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties.
34641480	3	70	dep	functional	606:615	arg1	hydrophobic					654:664	hydrophobic	654:664	hydrophobic	654:664	These hydrogels were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties.
34641480	3	70	dep	functional	606:615	arg1	morphology					626:635	morphology	626:635	morphology	626:635	These hydrogels were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties.
34641480	11	71	from	%	1797:1797	arg1	min					1855:1857	140 min	1851:1857	140 min	1851:1857	The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min.
34641480	11	71	from	%	1797:1797	arg1	media					1832:1836	phosphate buffer saline (PBS) media	1802:1836	phosphate buffer saline (PBS) media	1802:1836	The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min.
34641480	8	72	theme	drug	1355:1358	arg1	release					1360:1366	controlled drug release	1344:1366	controlled drug release	1344:1366	These hydrogels are pH-sensitive and appropriate for controlled drug release.
34641480	0	73	theme	Wound	117:121	arg1	Dressing					123:130	Wound Dressing	117:130	Wound Dressing	117:130	Development of Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing.
34641480	14	74	theme	wound	2239:2243	arg1	dressing					2245:2252	wound dressing	2239:2252	wound dressing in biomedical applications	2239:2279	Hence, from the results, these hydrogels could be a potential biomaterial for wound dressing in biomedical applications.
34641480	3	75	theme	Fourier-transform	493:509	arg1	spectroscopy					520:531	Fourier-transform infrared spectroscopy	493:531	Fourier-transform infrared spectroscopy (FTIR)	493:538	These hydrogels were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties.
34641480	3	75	theme	Fourier-transform	493:509	arg1	FTIR					534:537	FTIR	534:537	FTIR	534:537	These hydrogels were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties.
34641480	6	76	theme	hydrogel	1118:1125	arg1	behaviour					1105:1113	the swelling behaviour	1092:1113	the swelling behaviour of hydrogel	1092:1125	In various solvents, including water, buffer, and electrolyte solutions, the swelling behaviour of hydrogel was investigated and observed that TEOS amount caused less hydrogel swelling.
34641480	4	77	theme	corresponding	815:827	arg1	media					829:833	corresponding media	815:833	corresponding media	815:833	The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media.
34641480	11	78	theme	drug	1768:1771	arg1	mechanism					1781:1789	The drug release mechanism	1764:1789	The drug release mechanism	1764:1789	The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min.
34641480	11	78	theme	drug	1768:1771	arg1	%					1797:1797	98%	1795:1797	98%	1795:1797	The drug release mechanism was 98% in phosphate buffer saline (PBS) media at pH 7.4 in 140 min.
34641480	10	79	theme	bacterial	1745:1753	arg1	strains					1755:1761	Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains	1623:1761	Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains	1623:1761	The antimicrobial analysis revealed that these hydrogels are highly antibacterial against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains.
34641480	12	80	theme	release	1904:1910	arg1	kinetics					1912:1919	the drug release kinetics	1895:1919	the drug release kinetics	1895:1919	To analyze drug release behaviour, the drug release kinetics was assessed against different mathematical models (such as zero and first order, Higuchi, Baker-Lonsdale, Hixson, and Peppas).
34641480	9	81	theme	electrolyte	1510:1520	arg1	solutions					1522:1530	various electrolyte solutions	1502:1530	various electrolyte solutions	1502:1530	These hydrogels demonstrated that, as the ionic concentration was increased, swelling decreased due to decreased osmotic pressure in various electrolyte solutions.
34641480	10	82	theme	negative	1690:1697	arg1	strains					1755:1761	Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains	1623:1761	Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains	1623:1761	The antimicrobial analysis revealed that these hydrogels are highly antibacterial against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains.
34641480	0	83	theme	Chitosan/Guar	59:71	arg1	Hydrogels					103:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels	15:111	Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing	15:130	Development of Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing.
34641480	12	84	theme	drug	1871:1874	arg1	behaviour					1884:1892	drug release behaviour	1871:1892	drug release behaviour	1871:1892	To analyze drug release behaviour, the drug release kinetics was assessed against different mathematical models (such as zero and first order, Higuchi, Baker-Lonsdale, Hixson, and Peppas).
34641480	6	85	theme	hydrogel	1186:1193	arg1	swelling					1195:1202	less hydrogel swelling	1181:1202	less hydrogel swelling	1181:1202	In various solvents, including water, buffer, and electrolyte solutions, the swelling behaviour of hydrogel was investigated and observed that TEOS amount caused less hydrogel swelling.
34641480	3	86	theme	electron	550:557	arg1	SEM					571:573	SEM	571:573	SEM	571:573	These hydrogels were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties.
34641480	3	86	theme	electron	550:557	arg1	microscopy					559:568	scanning electron microscopy	541:568	scanning electron microscopy (SEM)	541:574	These hydrogels were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and wetting to determine the functional, surface morphology, hydrophilic, or hydrophobic properties.
34641480	4	87	from	kinetics	757:764	arg1	PBS					735:737	PBS	735:737	PBS	735:737	The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media.
34641480	4	87	from	kinetics	757:764	arg1	media					713:717	different media	703:717	different media	703:717	The swelling analysis in different media, degradation in PBS, and drug release kinetics were conducted to observe their response against corresponding media.
34641480	2	88	used	used	332:335	arg2	percentages					315:325	Different TEOS percentages	300:325	Different TEOS percentages	300:325	Different TEOS percentages were used because of their nontoxic behavior to study newly designed hydrogels' crosslinking and physicochemical properties.
34641480	13	89	theme	=	2149:2149	arg1	R2					2146:2147	R2	2146:2147	R2 = 0.98509	2146:2157	It was found that hydrogel (CPG2) follows the Peppas model with the highest value of regression (R2 = 0.98509).
34641480	9	90	from	pressure	1490:1497	arg1	solutions					1522:1530	various electrolyte solutions	1502:1530	various electrolyte solutions	1502:1530	These hydrogels demonstrated that, as the ionic concentration was increased, swelling decreased due to decreased osmotic pressure in various electrolyte solutions.
34641480	6	91	theme	TEOS	1162:1165	arg1	amount					1167:1172	TEOS amount	1162:1172	TEOS amount	1162:1172	In various solvents, including water, buffer, and electrolyte solutions, the swelling behaviour of hydrogel was investigated and observed that TEOS amount caused less hydrogel swelling.
34641480	2	92	theme	designed	387:394	arg1	hydrogels					396:404	newly designed hydrogels	381:404	newly designed hydrogels' crosslinking and physicochemical properties	381:449	Different TEOS percentages were used because of their nontoxic behavior to study newly designed hydrogels' crosslinking and physicochemical properties.
32268126	0	0	theme	composites	90:99	arg1	measurement					50:60	nonlinear optical measurement	32:60	nonlinear optical measurement of laser printed biopolymer composites comprising chitosan/SWCNT	32:125	Spectral analysis combined with nonlinear optical measurement of laser printed biopolymer composites comprising chitosan/SWCNT.
32268126	4	1	contain	has	723:725	arg1	chitosan					714:721	low-molecular chitosan	700:721	low-molecular chitosan	700:721	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	4	1	contain	has	723:725	arg2	coefficient					756:766	a large nonlinear absorption coefficient	727:766	a large nonlinear absorption coefficient of 17 cm/GW	727:778	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	1	2	theme	chitosan	172:179	arg1	types					163:167	two types	159:167	two types of chitosan (chitosan succinate and low-molecular weight chitosan)	159:234	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	4	3	theme	nonlinear	595:603	arg1	process					613:619	the nonlinear optical process	591:619	the nonlinear optical process during the interaction of laser radiation with a disperse media	591:683	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	0	4	theme	biopolymer	79:88	arg1	composites					90:99	laser printed biopolymer composites	65:99	laser printed biopolymer composites comprising chitosan/SWCNT	65:125	Spectral analysis combined with nonlinear optical measurement of laser printed biopolymer composites comprising chitosan/SWCNT.
32268126	6	5	theme	liquid	1045:1050	arg1	transformation					1025:1038	the transformation	1021:1038	the transformation of a liquid into a solid phase	1021:1069	If intensity exceeds the threshold value, nonlinear effects occur, which, in turn, lead to the transformation of a liquid into a solid phase.
32268126	7	6	theme	Raman	1110:1114	arg1	spectroscopy					1116:1127	FTIR and Raman spectroscopy	1101:1127	spectroscopy	1116:1127	Characterization of films by FTIR and Raman spectroscopy indicated arising molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM).
32268126	2	7	from	dispersibility	328:341	arg1	solutions					355:363	chitosan solutions	346:363	chitosan solutions	346:363	SWCNT have good dispersibility in chitosan solutions and therefore, can form relatively homogeneous films that was shown in scanning electron microscopy images.
32268126	7	8	from	shift	1227:1231	arg1	shape					1253:1257	the shape	1249:1257	the shape of radial breathing mode (RBM)	1249:1288	Characterization of films by FTIR and Raman spectroscopy indicated arising molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM).
32268126	3	9	from	action	527:532	arg1	media					575:579	aqueous dispersion media	556:579	aqueous dispersion media	556:579	For the studies film composites were formed under the action of laser radiation on aqueous dispersion media.
32268126	3	10	theme	aqueous	556:562	arg1	media					575:579	aqueous dispersion media	556:579	aqueous dispersion media	556:579	For the studies film composites were formed under the action of laser radiation on aqueous dispersion media.
32268126	4	11	theme	17 cm/GW	771:778	arg1	coefficient					756:766	a large nonlinear absorption coefficient	727:766	a large nonlinear absorption coefficient of 17 cm/GW	727:778	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	4	12	theme	process	613:619	arg1	Study					582:586	Study	582:586	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media	582:683	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	7	13	theme	FTIR	1101:1104	arg1	spectroscopy					1116:1127	FTIR and Raman spectroscopy	1101:1127	spectroscopy	1116:1127	Characterization of films by FTIR and Raman spectroscopy indicated arising molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM).
32268126	3	14	theme	dispersion	564:573	arg1	media					575:579	aqueous dispersion media	556:579	aqueous dispersion media	556:579	For the studies film composites were formed under the action of laser radiation on aqueous dispersion media.
32268126	4	15	theme	optical	605:611	arg1	process					613:619	the nonlinear optical process	591:619	the nonlinear optical process during the interaction of laser radiation with a disperse media	591:683	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	7	16	theme	radial	1262:1267	arg1	RBM					1285:1287	RBM	1285:1287	RBM	1285:1287	Characterization of films by FTIR and Raman spectroscopy indicated arising molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM).
32268126	7	16	theme	radial	1262:1267	arg1	mode					1279:1282	radial breathing mode	1262:1282	radial breathing mode (RBM)	1262:1288	Characterization of films by FTIR and Raman spectroscopy indicated arising molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM).
32268126	4	17	theme	laser	647:651	arg1	radiation					653:661	laser radiation	647:661	laser radiation	647:661	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	3	18	theme	radiation	543:551	arg1	action					527:532	the action	523:532	the action of laser radiation on aqueous dispersion media	523:579	For the studies film composites were formed under the action of laser radiation on aqueous dispersion media.
32268126	1	19	theme	chitosan	182:189	arg1	succinate					191:199	chitosan succinate	182:199	chitosan succinate	182:199	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	7	20	theme	films	1092:1096	arg1	Characterization					1072:1087	Characterization	1072:1087	Characterization of films by FTIR and Raman spectroscopy	1072:1127	Characterization of films by FTIR and Raman spectroscopy indicated arising molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM).
32268126	4	21	theme	disperse	670:677	arg1	media					679:683	a disperse media	668:683	a disperse media	668:683	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	7	22	theme	frequency	1217:1225	arg1	shift					1227:1231	a small frequency shift	1209:1231	a small frequency shift	1209:1231	Characterization of films by FTIR and Raman spectroscopy indicated arising molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM).
32268126	1	23	with	composites	139:148	arg1	nanotubes					262:270	single-walled carbon nanotubes	241:270	single-walled carbon nanotubes (SWCNT)	241:278	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	1	23	with	composites	139:148	arg1	SWCNT					273:277	SWCNT	273:277	SWCNT	273:277	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	1	24	dep	chitosan	172:179	arg1	chitosan					226:233	low-molecular weight chitosan	205:233	low-molecular weight chitosan	205:233	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	1	24	dep	chitosan	172:179	arg1	succinate					191:199	chitosan succinate	182:199	chitosan succinate	182:199	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	2	25	theme	homogeneous	400:410	arg1	films					412:416	relatively homogeneous films	389:416	relatively homogeneous films that was shown in scanning electron microscopy images	389:470	SWCNT have good dispersibility in chitosan solutions and therefore, can form relatively homogeneous films that was shown in scanning electron microscopy images.
32268126	0	26	theme	Spectral	0:7	arg1	analysis					9:16	Spectral analysis	0:16	Spectral analysis	0:16	Spectral analysis combined with nonlinear optical measurement of laser printed biopolymer composites comprising chitosan/SWCNT.
32268126	2	27	theme	good	323:326	arg1	dispersibility					328:341	good dispersibility	323:341	good dispersibility in chitosan solutions	323:363	SWCNT have good dispersibility in chitosan solutions and therefore, can form relatively homogeneous films that was shown in scanning electron microscopy images.
32268126	1	28	theme	low-molecular	205:217	arg1	chitosan					226:233	low-molecular weight chitosan	205:233	low-molecular weight chitosan	205:233	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	2	29	theme	microscopy	454:463	arg1	images					465:470	scanning electron microscopy images	436:470	scanning electron microscopy images	436:470	SWCNT have good dispersibility in chitosan solutions and therefore, can form relatively homogeneous films that was shown in scanning electron microscopy images.
32268126	1	30	theme	laser	296:300	arg1	printing					302:309	laser printing	296:309	laser printing	296:309	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	2	31	theme	scanning	436:443	arg1	microscopy					454:463	scanning electron microscopy	436:463	scanning electron microscopy images	436:470	SWCNT have good dispersibility in chitosan solutions and therefore, can form relatively homogeneous films that was shown in scanning electron microscopy images.
32268126	2	32	theme	electron	445:452	arg1	microscopy					454:463	scanning electron microscopy	436:463	scanning electron microscopy images	436:470	SWCNT have good dispersibility in chitosan solutions and therefore, can form relatively homogeneous films that was shown in scanning electron microscopy images.
32268126	8	33	theme	aqueous	1334:1340	arg1	media					1353:1357	aqueous dispersion media	1334:1357	aqueous dispersion media based on chitosan and SWCNT	1334:1385	The results indicate the possibility using aqueous dispersion media based on chitosan and SWCNT to create three-dimensional films and scaffolds for tissue engineering by laser printing.
32268126	1	34	theme	Biopolymer	128:137	arg1	composites					139:148	Biopolymer composites	128:148	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT)	128:278	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	7	35	from	change	1239:1244	arg1	shape					1253:1257	the shape	1249:1257	the shape of radial breathing mode (RBM)	1249:1288	Characterization of films by FTIR and Raman spectroscopy indicated arising molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM).
32268126	3	36	theme	film	489:492	arg1	composites					494:503	film composites	489:503	film composites	489:503	For the studies film composites were formed under the action of laser radiation on aqueous dispersion media.
32268126	0	37	theme	optical	42:48	arg1	measurement					50:60	nonlinear optical measurement	32:60	nonlinear optical measurement of laser printed biopolymer composites comprising chitosan/SWCNT	32:125	Spectral analysis combined with nonlinear optical measurement of laser printed biopolymer composites comprising chitosan/SWCNT.
32268126	6	38	theme	nonlinear	972:980	arg1	effects					982:988	nonlinear effects	972:988	nonlinear effects	972:988	If intensity exceeds the threshold value, nonlinear effects occur, which, in turn, lead to the transformation of a liquid into a solid phase.
32268126	7	39	theme	mode	1279:1282	arg1	shape					1253:1257	the shape	1249:1257	the shape of radial breathing mode (RBM)	1249:1288	Characterization of films by FTIR and Raman spectroscopy indicated arising molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM).
32268126	0	40	theme	nonlinear	32:40	arg1	measurement					50:60	nonlinear optical measurement	32:60	nonlinear optical measurement of laser printed biopolymer composites comprising chitosan/SWCNT	32:125	Spectral analysis combined with nonlinear optical measurement of laser printed biopolymer composites comprising chitosan/SWCNT.
32268126	7	41	theme	molecular	1147:1155	arg1	interactions					1157:1168	molecular interactions	1147:1168	molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM)	1147:1288	Characterization of films by FTIR and Raman spectroscopy indicated arising molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM).
32268126	4	42	theme	significant	819:829	arg1	increase					831:838	a significant increase	817:838	a significant increase up to 902 cm/GW	817:854	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	5	43	theme	threshold	861:869	arg1	intensity					871:879	The threshold intensity	857:879	The threshold intensity for these samples	857:897	The threshold intensity for these samples was 5.5 MW/cm2 with nanotubes.
32268126	2	44	contain	have	318:321	arg2	dispersibility					328:341	good dispersibility	323:341	good dispersibility in chitosan solutions	323:363	SWCNT have good dispersibility in chitosan solutions and therefore, can form relatively homogeneous films that was shown in scanning electron microscopy images.
32268126	2	44	contain	have	318:321	arg1	SWCNT					312:316	SWCNT	312:316	SWCNT	312:316	SWCNT have good dispersibility in chitosan solutions and therefore, can form relatively homogeneous films that was shown in scanning electron microscopy images.
32268126	8	45	theme	tissue	1439:1444	arg1	engineering					1446:1456	tissue engineering	1439:1456	tissue engineering by laser printing	1439:1474	The results indicate the possibility using aqueous dispersion media based on chitosan and SWCNT to create three-dimensional films and scaffolds for tissue engineering by laser printing.
32268126	8	46	theme	dispersion	1342:1351	arg1	media					1353:1357	aqueous dispersion media	1334:1357	aqueous dispersion media based on chitosan and SWCNT	1334:1385	The results indicate the possibility using aqueous dispersion media based on chitosan and SWCNT to create three-dimensional films and scaffolds for tissue engineering by laser printing.
32268126	4	47	theme	large	729:733	arg1	coefficient					756:766	a large nonlinear absorption coefficient	727:766	a large nonlinear absorption coefficient of 17 cm/GW	727:778	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	6	48	theme	threshold	955:963	arg1	value					965:969	the threshold value	951:969	the threshold value	951:969	If intensity exceeds the threshold value, nonlinear effects occur, which, in turn, lead to the transformation of a liquid into a solid phase.
32268126	8	49	theme	laser	1461:1465	arg1	printing					1467:1474	laser printing	1461:1474	laser printing	1461:1474	The results indicate the possibility using aqueous dispersion media based on chitosan and SWCNT to create three-dimensional films and scaffolds for tissue engineering by laser printing.
32268126	4	50	theme	absorption	745:754	arg1	coefficient					756:766	a large nonlinear absorption coefficient	727:766	a large nonlinear absorption coefficient of 17 cm/GW	727:778	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	8	51	theme	three-dimensional	1397:1413	arg1	films					1415:1419	three-dimensional films	1397:1419	three-dimensional films	1397:1419	The results indicate the possibility using aqueous dispersion media based on chitosan and SWCNT to create three-dimensional films and scaffolds for tissue engineering by laser printing.
32268126	4	52	with	interaction	632:642	arg1	media					679:683	a disperse media	668:683	a disperse media	668:683	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	2	53	theme	chitosan	346:353	arg1	solutions					355:363	chitosan solutions	346:363	chitosan solutions	346:363	SWCNT have good dispersibility in chitosan solutions and therefore, can form relatively homogeneous films that was shown in scanning electron microscopy images.
32268126	1	54	theme	single-walled	241:253	arg1	nanotubes					262:270	single-walled carbon nanotubes	241:270	single-walled carbon nanotubes (SWCNT)	241:278	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	1	54	theme	single-walled	241:253	arg1	SWCNT					273:277	SWCNT	273:277	SWCNT	273:277	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	7	55	theme	small	1211:1215	arg1	shift					1227:1231	a small frequency shift	1209:1231	a small frequency shift	1209:1231	Characterization of films by FTIR and Raman spectroscopy indicated arising molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM).
32268126	7	56	theme	breathing	1269:1277	arg1	RBM					1285:1287	RBM	1285:1287	RBM	1285:1287	Characterization of films by FTIR and Raman spectroscopy indicated arising molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM).
32268126	7	56	theme	breathing	1269:1277	arg1	mode					1279:1282	radial breathing mode	1262:1282	radial breathing mode (RBM)	1262:1288	Characterization of films by FTIR and Raman spectroscopy indicated arising molecular interactions between chitosan and SWCNT detected as a small frequency shift and a change in the shape of radial breathing mode (RBM).
32268126	4	57	theme	SWCNT	803:807	arg1	addition					791:798	the addition	787:798	the addition of SWCNT	787:807	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	4	58	theme	nonlinear	735:743	arg1	coefficient					756:766	a large nonlinear absorption coefficient	727:766	a large nonlinear absorption coefficient of 17 cm/GW	727:778	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	1	59	theme	carbon	255:260	arg1	nanotubes					262:270	single-walled carbon nanotubes	241:270	single-walled carbon nanotubes (SWCNT)	241:278	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	1	59	theme	carbon	255:260	arg1	SWCNT					273:277	SWCNT	273:277	SWCNT	273:277	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	0	60	theme	printed	71:77	arg1	composites					90:99	laser printed biopolymer composites	65:99	laser printed biopolymer composites comprising chitosan/SWCNT	65:125	Spectral analysis combined with nonlinear optical measurement of laser printed biopolymer composites comprising chitosan/SWCNT.
32268126	1	61	theme	weight	219:224	arg1	chitosan					226:233	low-molecular weight chitosan	205:233	low-molecular weight chitosan	205:233	Biopolymer composites based on two types of chitosan (chitosan succinate and low-molecular weight chitosan) with single-walled carbon nanotubes (SWCNT) were created by laser printing.
32268126	4	62	theme	low-molecular	700:712	arg1	chitosan					714:721	low-molecular chitosan	700:721	low-molecular chitosan	700:721	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	6	63	theme	solid	1059:1063	arg1	phase					1065:1069	a solid phase	1057:1069	a solid phase	1057:1069	If intensity exceeds the threshold value, nonlinear effects occur, which, in turn, lead to the transformation of a liquid into a solid phase.
32268126	0	64	theme	laser	65:69	arg1	composites					90:99	laser printed biopolymer composites	65:99	laser printed biopolymer composites comprising chitosan/SWCNT	65:125	Spectral analysis combined with nonlinear optical measurement of laser printed biopolymer composites comprising chitosan/SWCNT.
32268126	4	65	theme	radiation	653:661	arg1	interaction					632:642	the interaction	628:642	the interaction of laser radiation with a disperse media	628:683	Study of the nonlinear optical process during the interaction of laser radiation with a disperse media has shown that low-molecular chitosan has a large nonlinear absorption coefficient of 17 cm/GW, while the addition of SWCNT lead to a significant increase up to 902 cm/GW.
32268126	3	66	theme	laser	537:541	arg1	radiation					543:551	laser radiation	537:551	laser radiation	537:551	For the studies film composites were formed under the action of laser radiation on aqueous dispersion media.
33357840	0	0	theme	multi-functional	111:126	arg1	applications					128:139	multi-functional applications	111:139	multi-functional applications	111:139	Temperature sensitive self-assembling hydroxybutyl chitosan nanoparticles with cationic enhancement effect for multi-functional applications.
33357840	5	1	theme	contaminant	767:777	arg1	tests					787:791	anionic contaminant removal tests	759:791	anionic contaminant removal tests	759:791	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	2	2	theme	amino	403:407	arg1	groups					409:414	amino groups	403:414	amino groups on HBC chains exposed on the surface of nanoparticles	403:468	During hydrophobic assembly, amino groups on HBC chains exposed on the surface of nanoparticles formed a poly-cationic structure.
33357840	6	3	theme	fibroblast	1041:1050	arg1	proliferation					977:989	proliferation	977:989	proliferation	977:989	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	6	3	theme	fibroblast	1041:1050	arg1	division					995:1002	division	995:1002	division	995:1002	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	5	4	theme	removal	779:785	arg1	tests					787:791	anionic contaminant removal tests	759:791	anionic contaminant removal tests	759:791	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	1	5	theme	substitution	195:206	arg1	degree					185:190	different degree	175:190	different degree of substitution (DS)	175:211	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS) were prepared using a homogeneous reaction system (KOH/urea), which could achieve temperature-dependent reversible morphological transition in aqueous solution.
33357840	6	6	theme	embryonic	1031:1039	arg1	fibroblast					1041:1050	mouse embryonic fibroblast	1025:1050	mouse embryonic fibroblast	1025:1050	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	7	7	theme	multi-functional	1158:1173	arg1	applications					1175:1186	multi-functional applications	1158:1186	multi-functional applications	1158:1186	These cationic HBC nanoparticles exhibited great potential in multi-functional applications.
33357840	6	8	theme	mouse	1025:1029	arg1	fibroblast					1041:1050	mouse embryonic fibroblast	1025:1050	mouse embryonic fibroblast	1025:1050	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	5	9	theme	superoxide	728:737	arg1	anion					739:743	superoxide anion	728:743	superoxide anion clearance	728:753	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	5	10	theme	anion	739:743	arg1	clearance					745:753	superoxide anion clearance	728:753	superoxide anion clearance	728:753	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	6	11	theme	cytocompatibility	909:925	arg1	test					927:930	the cytocompatibility test	905:930	the cytocompatibility test	905:930	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	5	12	theme	removal	857:863	arg1	effect					865:870	excellent flocculation and removal effect	830:870	excellent flocculation and removal effect of anionic composites	830:892	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	5	13	theme	anionic	875:881	arg1	composites					883:892	anionic composites	875:892	anionic composites	875:892	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	5	14	theme	clearance	745:753	arg1	results					688:694	the results	684:694	the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests	684:791	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	6	15	theme	mouse	1007:1011	arg1	fibroblast					1013:1022	mouse fibroblast	1007:1022	mouse fibroblast	1007:1022	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	1	16	with	chitosan	155:162	arg1	degree					185:190	different degree	175:190	different degree of substitution (DS)	175:211	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS) were prepared using a homogeneous reaction system (KOH/urea), which could achieve temperature-dependent reversible morphological transition in aqueous solution.
33357840	5	17	theme	composites	883:892	arg1	effect					865:870	excellent flocculation and removal effect	830:870	excellent flocculation and removal effect of anionic composites	830:892	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	0	18	theme	sensitive	12:20	arg1	chitosan					51:58	Temperature sensitive self-assembling hydroxybutyl chitosan	0:58	Temperature sensitive self-assembling hydroxybutyl chitosan	0:58	Temperature sensitive self-assembling hydroxybutyl chitosan nanoparticles with cationic enhancement effect for multi-functional applications.
33357840	2	19	theme	poly-cationic	479:491	arg1	structure					493:501	a poly-cationic structure	477:501	a poly-cationic structure	477:501	During hydrophobic assembly, amino groups on HBC chains exposed on the surface of nanoparticles formed a poly-cationic structure.
33357840	6	20	theme	fibroblast	1013:1022	arg1	proliferation					977:989	proliferation	977:989	proliferation	977:989	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	6	20	theme	fibroblast	1013:1022	arg1	division					995:1002	division	995:1002	division	995:1002	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	7	21	theme	great	1139:1143	arg1	potential					1145:1153	great potential	1139:1153	great potential	1139:1153	These cationic HBC nanoparticles exhibited great potential in multi-functional applications.
33357840	2	22	theme	HBC	419:421	arg1	chains					423:428	HBC chains	419:428	HBC chains exposed on the surface of nanoparticles	419:468	During hydrophobic assembly, amino groups on HBC chains exposed on the surface of nanoparticles formed a poly-cationic structure.
33357840	0	23	theme	hydroxybutyl	38:49	arg1	chitosan					51:58	Temperature sensitive self-assembling hydroxybutyl chitosan	0:58	Temperature sensitive self-assembling hydroxybutyl chitosan	0:58	Temperature sensitive self-assembling hydroxybutyl chitosan nanoparticles with cationic enhancement effect for multi-functional applications.
33357840	1	24	theme	temperature-dependent	295:315	arg1	transition					342:351	temperature-dependent reversible morphological transition	295:351	temperature-dependent reversible morphological transition	295:351	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS) were prepared using a homogeneous reaction system (KOH/urea), which could achieve temperature-dependent reversible morphological transition in aqueous solution.
33357840	7	25	theme	HBC	1111:1113	arg1	nanoparticles					1115:1127	These cationic HBC nanoparticles	1096:1127	These cationic HBC nanoparticles	1096:1127	These cationic HBC nanoparticles exhibited great potential in multi-functional applications.
33357840	2	26	from	groups	409:414	arg1	chains					423:428	HBC chains	419:428	HBC chains exposed on the surface of nanoparticles	419:468	During hydrophobic assembly, amino groups on HBC chains exposed on the surface of nanoparticles formed a poly-cationic structure.
33357840	1	27	theme	Hydroxybutyl	142:153	arg1	HBC					165:167	HBC	165:167	HBC	165:167	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS) were prepared using a homogeneous reaction system (KOH/urea), which could achieve temperature-dependent reversible morphological transition in aqueous solution.
33357840	1	27	theme	Hydroxybutyl	142:153	arg1	chitosan					155:162	Hydroxybutyl chitosan	142:162	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS)	142:211	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS) were prepared using a homogeneous reaction system (KOH/urea), which could achieve temperature-dependent reversible morphological transition in aqueous solution.
33357840	2	28	theme	nanoparticles	456:468	arg1	surface					445:451	the surface	441:451	the surface of nanoparticles	441:468	During hydrophobic assembly, amino groups on HBC chains exposed on the surface of nanoparticles formed a poly-cationic structure.
33357840	0	29	theme	self-assembling	22:36	arg1	chitosan					51:58	Temperature sensitive self-assembling hydroxybutyl chitosan	0:58	Temperature sensitive self-assembling hydroxybutyl chitosan	0:58	Temperature sensitive self-assembling hydroxybutyl chitosan nanoparticles with cationic enhancement effect for multi-functional applications.
33357840	1	30	theme	reversible	317:326	arg1	transition					342:351	temperature-dependent reversible morphological transition	295:351	temperature-dependent reversible morphological transition	295:351	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS) were prepared using a homogeneous reaction system (KOH/urea), which could achieve temperature-dependent reversible morphological transition in aqueous solution.
33357840	5	31	theme	coagulation	699:709	arg1	results					688:694	the results	684:694	the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests	684:791	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	3	32	theme	13C	553:555	arg1	NMR					557:559	13C NMR	553:559	13C NMR	553:559	The structure of HBCs was characterized by FTIR, 13C NMR, XRD, TGA and rheology.
33357840	5	33	theme	tests	787:791	arg1	results					688:694	the results	684:694	the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests	684:791	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	1	34	theme	morphological	328:340	arg1	transition					342:351	temperature-dependent reversible morphological transition	295:351	temperature-dependent reversible morphological transition	295:351	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS) were prepared using a homogeneous reaction system (KOH/urea), which could achieve temperature-dependent reversible morphological transition in aqueous solution.
33357840	6	35	theme	stem	1084:1087	arg1	cells					1089:1093	mesenchymal stem cells	1072:1093	mesenchymal stem cells	1072:1093	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	6	36	theme	marrow	1065:1070	arg1	proliferation					977:989	proliferation	977:989	proliferation	977:989	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	6	36	theme	marrow	1065:1070	arg1	division					995:1002	division	995:1002	division	995:1002	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	5	37	theme	bacteriostatic	712:725	arg1	results					688:694	the results	684:694	the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests	684:791	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	5	38	contain	had	826:828	arg1	nanoparticles					812:824	HBC nanoparticles	808:824	HBC nanoparticles	808:824	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	5	38	contain	had	826:828	arg2	effect					865:870	excellent flocculation and removal effect	830:870	excellent flocculation and removal effect of anionic composites	830:892	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	5	39	theme	excellent	830:838	arg1	flocculation					840:851	excellent flocculation	830:851	excellent flocculation	830:851	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	1	40	theme	homogeneous	235:245	arg1	KOH/urea					264:271	KOH/urea	264:271	KOH/urea	264:271	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS) were prepared using a homogeneous reaction system (KOH/urea), which could achieve temperature-dependent reversible morphological transition in aqueous solution.
33357840	1	40	theme	homogeneous	235:245	arg1	system					256:261	a homogeneous reaction system	233:261	a homogeneous reaction system (KOH/urea)	233:272	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS) were prepared using a homogeneous reaction system (KOH/urea), which could achieve temperature-dependent reversible morphological transition in aqueous solution.
33357840	0	41	theme	cationic	79:86	arg1	effect					100:105	cationic enhancement effect	79:105	cationic enhancement effect for multi-functional applications	79:139	Temperature sensitive self-assembling hydroxybutyl chitosan nanoparticles with cationic enhancement effect for multi-functional applications.
33357840	4	42	dep	morphology	589:598	arg1	mechanism					613:621	mechanism	613:621	mechanism	613:621	The morphology and assembly mechanism of HBC nanoparticles were studied by TEM, AFM and DLS.
33357840	4	42	dep	morphology	589:598	arg1	The					585:587	The	585:587	The	585:587	The morphology and assembly mechanism of HBC nanoparticles were studied by TEM, AFM and DLS.
33357840	7	43	theme	cationic	1102:1109	arg1	nanoparticles					1115:1127	These cationic HBC nanoparticles	1096:1127	These cationic HBC nanoparticles	1096:1127	These cationic HBC nanoparticles exhibited great potential in multi-functional applications.
33357840	5	44	theme	HBC	808:810	arg1	nanoparticles					812:824	HBC nanoparticles	808:824	HBC nanoparticles	808:824	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	1	45	theme	aqueous	356:362	arg1	solution					364:371	aqueous solution	356:371	aqueous solution	356:371	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS) were prepared using a homogeneous reaction system (KOH/urea), which could achieve temperature-dependent reversible morphological transition in aqueous solution.
33357840	2	46	theme	hydrophobic	381:391	arg1	assembly					393:400	hydrophobic assembly	381:400	hydrophobic assembly	381:400	During hydrophobic assembly, amino groups on HBC chains exposed on the surface of nanoparticles formed a poly-cationic structure.
33357840	5	47	theme	anionic	759:765	arg1	tests					787:791	anionic contaminant removal tests	759:791	anionic contaminant removal tests	759:791	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	3	48	theme	HBCs	521:524	arg1	structure					508:516	The structure	504:516	The structure of HBCs	504:524	The structure of HBCs was characterized by FTIR, 13C NMR, XRD, TGA and rheology.
33357840	1	49	theme	reaction	247:254	arg1	KOH/urea					264:271	KOH/urea	264:271	KOH/urea	264:271	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS) were prepared using a homogeneous reaction system (KOH/urea), which could achieve temperature-dependent reversible morphological transition in aqueous solution.
33357840	1	49	theme	reaction	247:254	arg1	system					256:261	a homogeneous reaction system	233:261	a homogeneous reaction system (KOH/urea)	233:272	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS) were prepared using a homogeneous reaction system (KOH/urea), which could achieve temperature-dependent reversible morphological transition in aqueous solution.
33357840	6	50	dep	fibroblast	1013:1022	arg1	cells					1089:1093	mesenchymal stem cells	1072:1093	mesenchymal stem cells	1072:1093	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	6	51	theme	bone	1060:1063	arg1	marrow					1065:1070	rat bone marrow	1056:1070	rat bone marrow	1056:1070	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	6	52	theme	mesenchymal	1072:1082	arg1	cells					1089:1093	mesenchymal stem cells	1072:1093	mesenchymal stem cells	1072:1093	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	1	53	theme	different	175:183	arg1	degree					185:190	different degree	175:190	different degree of substitution (DS)	175:211	Hydroxybutyl chitosan (HBC) with different degree of substitution (DS) were prepared using a homogeneous reaction system (KOH/urea), which could achieve temperature-dependent reversible morphological transition in aqueous solution.
33357840	6	54	theme	rat	1056:1058	arg1	marrow					1065:1070	rat bone marrow	1056:1070	rat bone marrow	1056:1070	Moreover, the cytocompatibility test indicated that HBC could effectively promote proliferation and division of mouse fibroblast, mouse embryonic fibroblast and rat bone marrow mesenchymal stem cells.
33357840	0	55	theme	enhancement	88:98	arg1	effect					100:105	cationic enhancement effect	79:105	cationic enhancement effect for multi-functional applications	79:139	Temperature sensitive self-assembling hydroxybutyl chitosan nanoparticles with cationic enhancement effect for multi-functional applications.
33357840	5	56	theme	flocculation	840:851	arg1	effect					865:870	excellent flocculation and removal effect	830:870	excellent flocculation and removal effect of anionic composites	830:892	Also, the results of coagulation, bacteriostatic, superoxide anion clearance and anionic contaminant removal tests suggested that HBC nanoparticles had excellent flocculation and removal effect of anionic composites.
33357840	4	57	theme	HBC	626:628	arg1	nanoparticles					630:642	HBC nanoparticles	626:642	HBC nanoparticles	626:642	The morphology and assembly mechanism of HBC nanoparticles were studied by TEM, AFM and DLS.
33357840	4	58	theme	nanoparticles	630:642	arg1	assembly					604:611	assembly	604:611	assembly	604:611	The morphology and assembly mechanism of HBC nanoparticles were studied by TEM, AFM and DLS.
33357840	4	58	theme	nanoparticles	630:642	arg1	morphology					589:598	morphology	589:598	morphology	589:598	The morphology and assembly mechanism of HBC nanoparticles were studied by TEM, AFM and DLS.
33476620	3	0	theme	nanofiller	644:653	arg1	content					655:661	a minimal nanofiller content	634:661	a minimal nanofiller content of 0.2 wt%	634:672	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	0	1	theme	chitosan	72:79	arg1	nanowhiskers					81:92	chitosan nanowhiskers	72:92	chitosan nanowhiskers	72:92	Highly reinforced poly(butylene succinate) nanocomposites prepared from chitosan nanowhiskers by in-situ polymerization.
33476620	6	2	theme	tear	1228:1231	arg1	stress					1233:1238	tear stress	1228:1238	tear stress	1228:1238	The highly polar surfaces of the CsWs strongly bind to polymer chains and promote a fibrillar and micro-void structure, thereby maximizing the chain-holding ability of the nanofiller, which resists external tensile and tear stress.
33476620	6	3	theme	polymer	1064:1070	arg1	chains					1072:1077	polymer chains	1064:1077	polymer chains	1064:1077	The highly polar surfaces of the CsWs strongly bind to polymer chains and promote a fibrillar and micro-void structure, thereby maximizing the chain-holding ability of the nanofiller, which resists external tensile and tear stress.
33476620	0	4	theme	in-situ	97:103	arg1	polymerization					105:118	in-situ polymerization	97:118	in-situ polymerization	97:118	Highly reinforced poly(butylene succinate) nanocomposites prepared from chitosan nanowhiskers by in-situ polymerization.
33476620	7	5	theme	disposable	1327:1336	arg1	commodities					1338:1348	biodegradable disposable commodities	1313:1348	biodegradable disposable commodities	1313:1348	This sustainable all-organic nanocomposite is a promising candidate for biodegradable disposable commodities.
33476620	4	6	theme	cellulose	815:823	arg1	nanocrystals					825:836	cellulose nanocrystals	815:836	cellulose nanocrystals	815:836	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	7	7	theme	all-organic	1258:1268	arg1	candidate					1299:1307	a promising candidate	1287:1307	a promising candidate for biodegradable disposable commodities	1287:1348	This sustainable all-organic nanocomposite is a promising candidate for biodegradable disposable commodities.
33476620	7	7	theme	all-organic	1258:1268	arg1	nanocomposite					1270:1282	This sustainable all-organic nanocomposite	1241:1282	This sustainable all-organic nanocomposite	1241:1282	This sustainable all-organic nanocomposite is a promising candidate for biodegradable disposable commodities.
33476620	6	8	theme	nanofiller	1181:1190	arg1	ability					1166:1172	the chain-holding ability	1148:1172	the chain-holding ability of the nanofiller, which resists external tensile and tear stress	1148:1238	The highly polar surfaces of the CsWs strongly bind to polymer chains and promote a fibrillar and micro-void structure, thereby maximizing the chain-holding ability of the nanofiller, which resists external tensile and tear stress.
33476620	6	9	theme	fibrillar	1093:1101	arg1	structure					1118:1126	a fibrillar and micro-void structure	1091:1126	a fibrillar and micro-void structure	1091:1126	The highly polar surfaces of the CsWs strongly bind to polymer chains and promote a fibrillar and micro-void structure, thereby maximizing the chain-holding ability of the nanofiller, which resists external tensile and tear stress.
33476620	3	10	theme	0.2 wt	666:671	arg1	%					672:672	0.2 wt%	666:672	0.2 wt%	666:672	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	3	11	theme	highest	531:537	arg1	strength					547:554	the highest tensile strength	527:554	the highest tensile strength (77 MPa)	527:563	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	3	11	theme	highest	531:537	arg1	77 MPa					557:562	77 MPa	557:562	77 MPa	557:562	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	3	12	from	break	583:587	arg1	elongation					569:578	elongation	569:578	elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%	569:672	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	3	12	from	break	583:587	arg1	strength					547:554	the highest tensile strength	527:554	the highest tensile strength (77 MPa)	527:563	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	3	12	from	break	583:587	arg1	77 MPa					557:562	77 MPa	557:562	77 MPa	557:562	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	4	13	from	CsWs	883:886	arg1	monomer					906:912	1,4-butanediol monomer	891:912	1,4-butanediol monomer	891:912	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	3	14	theme	%	672:672	arg1	content					655:661	a minimal nanofiller content	634:661	a minimal nanofiller content of 0.2 wt%	634:672	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	6	15	theme	external	1207:1214	arg1	tensile					1216:1222	external tensile	1207:1222	external tensile	1207:1222	The highly polar surfaces of the CsWs strongly bind to polymer chains and promote a fibrillar and micro-void structure, thereby maximizing the chain-holding ability of the nanofiller, which resists external tensile and tear stress.
33476620	3	16	theme	aqueous	460:466	arg1	solution					468:475	an aqueous solution	457:475	an aqueous solution of processed CsWs	457:493	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	6	17	theme	micro-void	1107:1116	arg1	structure					1118:1126	a fibrillar and micro-void structure	1091:1126	a fibrillar and micro-void structure	1091:1126	The highly polar surfaces of the CsWs strongly bind to polymer chains and promote a fibrillar and micro-void structure, thereby maximizing the chain-holding ability of the nanofiller, which resists external tensile and tear stress.
33476620	1	18	theme	commodity-plastic	177:193	arg1	bags					228:231	disposable bags	217:231	disposable bags	217:231	Biodegradable aliphatic polyesters need to be tough for commodity-plastic applications, such as disposable bags.
33476620	1	18	theme	commodity-plastic	177:193	arg1	applications					195:206	commodity-plastic applications	177:206	commodity-plastic applications	177:206	Biodegradable aliphatic polyesters need to be tough for commodity-plastic applications, such as disposable bags.
33476620	4	19	theme	1,4-butanediol	891:904	arg1	monomer					906:912	1,4-butanediol monomer	891:912	1,4-butanediol monomer	891:912	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	2	20	dep	strength	371:378	arg1	the					367:369	the	367:369	the	367:369	Herein, we show that chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin is an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS).
33476620	3	21	theme	processed	480:488	arg1	CsWs					490:493	processed CsWs	480:493	processed CsWs	480:493	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	2	22	theme	poly	397:400	arg1	PBS					423:425	poly(butylene succinate) (PBS)	397:426	poly(butylene succinate) (PBS)	397:426	Herein, we show that chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin is an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS).
33476620	0	23	theme	reinforced	7:16	arg1	poly					18:21	Highly reinforced poly	0:21	Highly reinforced poly(butylene succinate)	0:41	Highly reinforced poly(butylene succinate) nanocomposites prepared from chitosan nanowhiskers by in-situ polymerization.
33476620	0	23	theme	reinforced	7:16	arg1	succinate					32:40	butylene succinate	23:40	butylene succinate	23:40	Highly reinforced poly(butylene succinate) nanocomposites prepared from chitosan nanowhiskers by in-situ polymerization.
33476620	4	24	theme	3.2-fold	688:695	arg1	superior					768:775	superior	768:775	superior	768:775	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	4	24	theme	3.2-fold	688:695	arg1	increase					697:704	The observed 3.2-fold increase	675:704	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS	675:763	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	4	25	from	nanowhiskers	846:857	arg1	monomer					906:912	1,4-butanediol monomer	891:912	1,4-butanediol monomer	891:912	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	6	26	theme	polar	1020:1024	arg1	surfaces					1026:1033	The highly polar surfaces	1009:1033	The highly polar surfaces of the CsWs	1009:1045	The highly polar surfaces of the CsWs strongly bind to polymer chains and promote a fibrillar and micro-void structure, thereby maximizing the chain-holding ability of the nanofiller, which resists external tensile and tear stress.
33476620	4	27	from	increase	697:704	arg1	toughness					709:717	toughness	709:717	toughness of the CsW/PBS composite	709:742	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	3	28	theme	tensile	539:545	arg1	strength					547:554	the highest tensile strength	527:554	the highest tensile strength (77 MPa)	527:563	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	3	28	theme	tensile	539:545	arg1	77 MPa					557:562	77 MPa	557:562	77 MPa	557:562	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	4	29	theme	neat	756:759	arg1	PBS					761:763	neat PBS	756:763	neat PBS	756:763	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	7	30	theme	sustainable	1246:1256	arg1	candidate					1299:1307	a promising candidate	1287:1307	a promising candidate for biodegradable disposable commodities	1287:1348	This sustainable all-organic nanocomposite is a promising candidate for biodegradable disposable commodities.
33476620	7	30	theme	sustainable	1246:1256	arg1	nanocomposite					1270:1282	This sustainable all-organic nanocomposite	1241:1282	This sustainable all-organic nanocomposite	1241:1282	This sustainable all-organic nanocomposite is a promising candidate for biodegradable disposable commodities.
33476620	2	31	theme	PBS	423:425	arg1	toughness					384:392	toughness	384:392	toughness	384:392	Herein, we show that chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin is an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS).
33476620	2	31	theme	PBS	423:425	arg1	strength					371:378	strength	371:378	strength	371:378	Herein, we show that chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin is an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS).
33476620	4	32	theme	observed	679:686	arg1	superior					768:775	superior	768:775	superior	768:775	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	4	32	theme	observed	679:686	arg1	increase					697:704	The observed 3.2-fold increase	675:704	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS	675:763	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	1	33	theme	disposable	217:226	arg1	bags					228:231	disposable bags	217:231	disposable bags	217:231	Biodegradable aliphatic polyesters need to be tough for commodity-plastic applications, such as disposable bags.
33476620	3	34	with	nanocomposite	508:520	arg1	elongation					569:578	elongation	569:578	elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%	569:672	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	3	34	with	nanocomposite	508:520	arg1	strength					547:554	the highest tensile strength	527:554	the highest tensile strength (77 MPa)	527:563	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	3	34	with	nanocomposite	508:520	arg1	77 MPa					557:562	77 MPa	557:562	77 MPa	557:562	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	3	35	theme	CsWs	490:493	arg1	solution					468:475	an aqueous solution	457:475	an aqueous solution of processed CsWs	457:493	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	4	36	theme	dispersed	873:881	arg1	CsWs					883:886	unstably dispersed CsWs	864:886	unstably dispersed CsWs in 1,4-butanediol monomer	864:912	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	0	37	dep	nanocomposites	43:56	arg1	prepared					58:65	prepared	58:65	nanocomposites prepared from chitosan nanowhiskers by in-situ polymerization	43:118	Highly reinforced poly(butylene succinate) nanocomposites prepared from chitosan nanowhiskers by in-situ polymerization.
33476620	0	38	theme	butylene	23:30	arg1	poly					18:21	Highly reinforced poly	0:21	Highly reinforced poly(butylene succinate)	0:41	Highly reinforced poly(butylene succinate) nanocomposites prepared from chitosan nanowhiskers by in-situ polymerization.
33476620	0	38	theme	butylene	23:30	arg1	succinate					32:40	butylene succinate	23:40	butylene succinate	23:40	Highly reinforced poly(butylene succinate) nanocomposites prepared from chitosan nanowhiskers by in-situ polymerization.
33476620	2	39	theme	butylene	402:409	arg1	poly					397:400	poly	397:400	poly(butylene succinate) (PBS)	397:426	Herein, we show that chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin is an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS).
33476620	2	39	theme	butylene	402:409	arg1	succinate					411:419	butylene succinate	402:419	butylene succinate	402:419	Herein, we show that chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin is an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS).
33476620	5	40	theme	PBS	981:983	arg1	film					985:988	the PBS film	977:988	the PBS film that easily tears	977:1006	Interestingly, CsWs efficiently overcome the disadvantages of the PBS film that easily tears.
33476620	1	41	theme	Biodegradable	121:133	arg1	polyesters					145:154	Biodegradable aliphatic polyesters	121:154	Biodegradable aliphatic polyesters	121:154	Biodegradable aliphatic polyesters need to be tough for commodity-plastic applications, such as disposable bags.
33476620	3	42	theme	PBS	621:623	arg1	types					625:629	all PBS types	617:629	all PBS types	617:629	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	5	43	theme	film	985:988	arg1	disadvantages					960:972	the disadvantages	956:972	the disadvantages of the PBS film that easily tears	956:1006	Interestingly, CsWs efficiently overcome the disadvantages of the PBS film that easily tears.
33476620	7	44	theme	promising	1289:1297	arg1	candidate					1299:1307	a promising candidate	1287:1307	a promising candidate for biodegradable disposable commodities	1287:1348	This sustainable all-organic nanocomposite is a promising candidate for biodegradable disposable commodities.
33476620	7	44	theme	promising	1289:1297	arg1	nanocomposite					1270:1282	This sustainable all-organic nanocomposite	1241:1282	This sustainable all-organic nanocomposite	1241:1282	This sustainable all-organic nanocomposite is a promising candidate for biodegradable disposable commodities.
33476620	1	45	theme	aliphatic	135:143	arg1	polyesters					145:154	Biodegradable aliphatic polyesters	121:154	Biodegradable aliphatic polyesters	121:154	Biodegradable aliphatic polyesters need to be tough for commodity-plastic applications, such as disposable bags.
33476620	6	46	theme	chain-holding	1152:1164	arg1	ability					1166:1172	the chain-holding ability	1148:1172	the chain-holding ability of the nanofiller, which resists external tensile and tear stress	1148:1238	The highly polar surfaces of the CsWs strongly bind to polymer chains and promote a fibrillar and micro-void structure, thereby maximizing the chain-holding ability of the nanofiller, which resists external tensile and tear stress.
33476620	4	47	theme	CsW/PBS	726:732	arg1	composite					734:742	the CsW/PBS composite	722:742	the CsW/PBS composite	722:742	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	2	48	theme	effective	330:338	arg1	nanofiller					340:349	an effective nanofiller	327:349	an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS)	327:426	Herein, we show that chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin is an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS).
33476620	2	48	theme	effective	330:338	arg1	nanowhiskers					264:275	chitosan nanowhiskers	255:275	chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin	255:322	Herein, we show that chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin is an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS).
33476620	2	49	theme	abundant	308:315	arg1	chitin					317:322	naturally abundant chitin	298:322	naturally abundant chitin	298:322	Herein, we show that chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin is an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS).
33476620	4	50	theme	chitin	839:844	arg1	nanowhiskers					846:857	chitin nanowhiskers	839:857	chitin nanowhiskers	839:857	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	7	51	theme	biodegradable	1313:1325	arg1	commodities					1338:1348	biodegradable disposable commodities	1313:1348	biodegradable disposable commodities	1313:1348	This sustainable all-organic nanocomposite is a promising candidate for biodegradable disposable commodities.
33476620	6	52	theme	CsWs	1042:1045	arg1	surfaces					1026:1033	The highly polar surfaces	1009:1033	The highly polar surfaces of the CsWs	1009:1045	The highly polar surfaces of the CsWs strongly bind to polymer chains and promote a fibrillar and micro-void structure, thereby maximizing the chain-holding ability of the nanofiller, which resists external tensile and tear stress.
33476620	3	53	theme	solution	468:475	arg1	polycondensation					437:452	In-situ polycondensation	429:452	In-situ polycondensation of an aqueous solution of processed CsWs	429:493	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	4	54	from	nanocrystals	825:836	arg1	monomer					906:912	1,4-butanediol monomer	891:912	1,4-butanediol monomer	891:912	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	2	55	theme	chitosan	255:262	arg1	nanofiller					340:349	an effective nanofiller	327:349	an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS)	327:426	Herein, we show that chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin is an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS).
33476620	2	55	theme	chitosan	255:262	arg1	CsWs					278:281	CsWs	278:281	CsWs	278:281	Herein, we show that chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin is an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS).
33476620	2	55	theme	chitosan	255:262	arg1	nanowhiskers					264:275	chitosan nanowhiskers	255:275	chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin	255:322	Herein, we show that chitosan nanowhiskers (CsWs) prepared from naturally abundant chitin is an effective nanofiller that reinforces the strength and toughness of poly(butylene succinate) (PBS).
33476620	3	56	theme	In-situ	429:435	arg1	polycondensation					437:452	In-situ polycondensation	429:452	In-situ polycondensation of an aqueous solution of processed CsWs	429:493	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	3	57	theme	minimal	636:642	arg1	content					655:661	a minimal nanofiller content	634:661	a minimal nanofiller content of 0.2 wt%	634:672	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
33476620	4	58	theme	composite	734:742	arg1	toughness					709:717	toughness	709:717	toughness of the CsW/PBS composite	709:742	The observed 3.2-fold increase in toughness of the CsW/PBS composite compared to neat PBS is superior to those of composites prepared using cellulose nanocrystals, chitin nanowhiskers, and unstably dispersed CsWs in 1,4-butanediol monomer.
33476620	3	59	theme	PBS	504:506	arg1	nanocomposite					508:520	a PBS nanocomposite	502:520	a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%	502:672	In-situ polycondensation of an aqueous solution of processed CsWs led to a PBS nanocomposite with the highest tensile strength (77 MPa) and elongation at break (530%) reported to date for all PBS types at a minimal nanofiller content of 0.2 wt%.
34641521	7	0	theme	catalytic	1140:1148	arg1	profiles					1150:1157	the catalytic profiles	1136:1157	the catalytic profiles	1136:1157	However, the catalytic profiles significantly differ between the two enzymes despite almost identical catalytic sites.
34641521	2	1	theme	enzyme	395:400	arg1	rChit62J4					402:410	recombinant enzyme rChit62J4	383:410	recombinant enzyme rChit62J4	383:410	We characterized the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat.
34641521	4	2	theme	genome	737:742	arg1	sequencing					744:753	bacterial genome sequencing	727:753	bacterial genome sequencing	727:753	Sequence comparison of the amino acid sequence of Chit62J4, determined during bacterial genome sequencing, characterizes the enzyme as a family 18 glycosyl hydrolase with a four-domain structure.
34641521	5	3	from	activity	1003:1010	arg1	fibers					1022:1027	chitin fibers	1015:1027	chitin fibers	1015:1027	The catalytic domain has the typical TIM barrel structure and the accessory domains-2x Fn3/Big3 and a carbohydrate binding module-that likely supports enzyme activity on chitin fibers.
34641521	8	4	theme	optimum	1269:1275	arg1	shift					1250:1254	The shift	1246:1254	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium	1246:1351	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	8	4	theme	optimum	1269:1275	arg1	adaptation					1381:1390	the likely environmental adaptation	1356:1390	the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria	1356:1479	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	3	5	theme	processes	595:603	arg1	pNGG					605:608	5.5 and processes pNGG	587:608	5.5 and processes pNGG	587:608	This major chitinase, securing nutrition of the bacterium in the human intestinal tract when supplied with chitin, has a pH optimum of 5.5 and processes pNGG with Km = 0.24 mM and kcat = 30.0 s-1.
34641521	1	6	theme	kDa	229:231	arg1	Chit62J4					243:250	a 62 kDa chitinase Chit62J4	224:250	a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N	224:280	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	1	6	theme	kDa	229:231	arg1	β-d-chitobioside					294:309	N'-diacetyl-β-d-chitobioside	282:309	N'-diacetyl-β-d-chitobioside (pNGG)	282:316	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	2	7	theme	crude	340:344	arg1	enzyme					346:351	the crude enzyme	336:351	the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat	336:449	We characterized the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat.
34641521	1	8	theme	paraputrificum	144:157	arg1	J4					159:160	Commensal bacterium Clostridium paraputrificum J4	112:160	Commensal bacterium Clostridium paraputrificum J4	112:160	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	8	9	theme	enzyme	1294:1299	arg1	pI					1259:1260	pI	1259:1260	pI	1259:1260	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	8	9	theme	enzyme	1294:1299	arg1	optimum					1269:1275	pH optimum	1266:1275	pH optimum	1266:1275	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	5	10	theme	catalytic	849:857	arg1	domain					859:864	The catalytic domain	845:864	The catalytic domain	845:864	The catalytic domain has the typical TIM barrel structure and the accessory domains-2x Fn3/Big3 and a carbohydrate binding module-that likely supports enzyme activity on chitin fibers.
34641521	8	11	theme	acidic	1308:1313	arg1	values					1315:1320	acidic values	1308:1320	acidic values	1308:1320	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	5	12	theme	accessory	911:919	arg1	Fn3/Big3					932:939	the accessory domains-2x Fn3/Big3	907:939	the accessory domains-2x Fn3/Big3	907:939	The catalytic domain has the typical TIM barrel structure and the accessory domains-2x Fn3/Big3 and a carbohydrate binding module-that likely supports enzyme activity on chitin fibers.
34641521	5	13	theme	carbohydrate	947:958	arg1	module-that					968:978	a carbohydrate binding module-that	945:978	a carbohydrate binding module-that	945:978	The catalytic domain has the typical TIM barrel structure and the accessory domains-2x Fn3/Big3 and a carbohydrate binding module-that likely supports enzyme activity on chitin fibers.
34641521	6	14	theme	catalytic	1034:1042	arg1	homologous					1061:1070	homologous	1061:1070	homologous	1061:1070	The catalytic domain is highly homologous to a single-domain chitinase of Bacillus cereus NCTU2.
34641521	6	14	theme	catalytic	1034:1042	arg1	domain					1044:1049	The catalytic domain	1030:1049	The catalytic domain	1030:1049	The catalytic domain is highly homologous to a single-domain chitinase of Bacillus cereus NCTU2.
34641521	4	15	theme	acid	682:685	arg1	sequence					687:694	the amino acid sequence	672:694	the amino acid sequence of Chit62J4	672:706	Sequence comparison of the amino acid sequence of Chit62J4, determined during bacterial genome sequencing, characterizes the enzyme as a family 18 glycosyl hydrolase with a four-domain structure.
34641521	0	16	theme	Microbiome	60:69	arg1	J4					108:109	Human Microbiome Bacterium Clostridium paraputrificum J4	54:109	Human Microbiome Bacterium Clostridium paraputrificum J4	54:109	Chitinase Chit62J4 Essential for Chitin Processing by Human Microbiome Bacterium Clostridium paraputrificum J4.
34641521	5	17	theme	barrel	886:891	arg1	structure					893:901	the typical TIM barrel structure	870:901	the typical TIM barrel structure	870:901	The catalytic domain has the typical TIM barrel structure and the accessory domains-2x Fn3/Big3 and a carbohydrate binding module-that likely supports enzyme activity on chitin fibers.
34641521	0	18	theme	Clostridium	81:91	arg1	J4					108:109	Human Microbiome Bacterium Clostridium paraputrificum J4	54:109	Human Microbiome Bacterium Clostridium paraputrificum J4	54:109	Chitinase Chit62J4 Essential for Chitin Processing by Human Microbiome Bacterium Clostridium paraputrificum J4.
34641521	1	19	theme	bacterium	122:130	arg1	J4					159:160	Commensal bacterium Clostridium paraputrificum J4	112:160	Commensal bacterium Clostridium paraputrificum J4	112:160	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	8	20	theme	environmental	1367:1379	arg1	shift					1250:1254	The shift	1246:1254	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium	1246:1351	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	8	20	theme	environmental	1367:1379	arg1	adaptation					1381:1390	the likely environmental adaptation	1356:1390	the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria	1356:1479	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	7	21	theme	identical	1219:1227	arg1	sites					1239:1243	almost identical catalytic sites	1212:1243	almost identical catalytic sites	1212:1243	However, the catalytic profiles significantly differ between the two enzymes despite almost identical catalytic sites.
34641521	5	22	theme	enzyme	996:1001	arg1	activity					1003:1010	enzyme activity	996:1010	enzyme activity on chitin fibers	996:1027	The catalytic domain has the typical TIM barrel structure and the accessory domains-2x Fn3/Big3 and a carbohydrate binding module-that likely supports enzyme activity on chitin fibers.
34641521	2	23	dep	fluid	376:380	arg1	rChit62J4cat					438:449	rChit62J4cat	438:449	rChit62J4cat	438:449	We characterized the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat.
34641521	2	24	theme	catalytic	421:429	arg1	domain					431:436	its catalytic domain	417:436	its catalytic domain	417:436	We characterized the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat.
34641521	0	25	theme	Chitinase	0:8	arg1	Chit62J4					10:17	Chitinase Chit62J4	0:17	Chitinase Chit62J4 Essential for Chitin Processing by Human Microbiome Bacterium Clostridium paraputrificum J4.	0:110	Chitinase Chit62J4 Essential for Chitin Processing by Human Microbiome Bacterium Clostridium paraputrificum J4.
34641521	8	26	theme	C.	1406:1407	arg1	J4					1424:1425	C. paraputrificum J4	1406:1425	C. paraputrificum J4	1406:1425	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	0	27	theme	Essential	19:27	arg1	Chit62J4					10:17	Chitinase Chit62J4	0:17	Chitinase Chit62J4 Essential for Chitin Processing by Human Microbiome Bacterium Clostridium paraputrificum J4.	0:110	Chitinase Chit62J4 Essential for Chitin Processing by Human Microbiome Bacterium Clostridium paraputrificum J4.
34641521	5	28	theme	binding	960:966	arg1	module-that					968:978	a carbohydrate binding module-that	945:978	a carbohydrate binding module-that	945:978	The catalytic domain has the typical TIM barrel structure and the accessory domains-2x Fn3/Big3 and a carbohydrate binding module-that likely supports enzyme activity on chitin fibers.
34641521	1	29	theme	several	171:177	arg1	Chit62J4					243:250	a 62 kDa chitinase Chit62J4	224:250	a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N	224:280	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	1	29	theme	several	171:177	arg1	enzymes					206:212	several extracellular chitinolytic enzymes	171:212	several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG)	171:316	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	3	30	theme	major	457:461	arg1	chitinase					463:471	This major chitinase	452:471	This major chitinase	452:471	This major chitinase, securing nutrition of the bacterium in the human intestinal tract when supplied with chitin, has a pH optimum of 5.5 and processes pNGG with Km = 0.24 mM and kcat = 30.0 s-1.
34641521	0	31	theme	Chitin	33:38	arg1	Processing					40:49	Chitin Processing	33:49	Chitin Processing by Human Microbiome Bacterium Clostridium paraputrificum J4	33:109	Chitinase Chit62J4 Essential for Chitin Processing by Human Microbiome Bacterium Clostridium paraputrificum J4.
34641521	3	32	contain	has	567:569	arg2	optimum					576:582	a pH optimum	571:582	a pH optimum of 5.5 and processes pNGG	571:608	This major chitinase, securing nutrition of the bacterium in the human intestinal tract when supplied with chitin, has a pH optimum of 5.5 and processes pNGG with Km = 0.24 mM and kcat = 30.0 s-1.
34641521	3	32	contain	has	567:569	arg1	chitinase					463:471	This major chitinase	452:471	This major chitinase	452:471	This major chitinase, securing nutrition of the bacterium in the human intestinal tract when supplied with chitin, has a pH optimum of 5.5 and processes pNGG with Km = 0.24 mM and kcat = 30.0 s-1.
34641521	4	33	theme	four-domain	822:832	arg1	structure					834:842	a four-domain structure	820:842	a four-domain structure	820:842	Sequence comparison of the amino acid sequence of Chit62J4, determined during bacterial genome sequencing, characterizes the enzyme as a family 18 glycosyl hydrolase with a four-domain structure.
34641521	2	34	theme	recombinant	383:393	arg1	rChit62J4					402:410	recombinant enzyme rChit62J4	383:410	recombinant enzyme rChit62J4	383:410	We characterized the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat.
34641521	4	35	theme	family	786:791	arg1	enzyme					774:779	the enzyme	770:779	the enzyme	770:779	Sequence comparison of the amino acid sequence of Chit62J4, determined during bacterial genome sequencing, characterizes the enzyme as a family 18 glycosyl hydrolase with a four-domain structure.
34641521	4	35	theme	family	786:791	arg1	hydrolase					805:813	a family 18 glycosyl hydrolase	784:813	a family 18 glycosyl hydrolase with a four-domain structure	784:842	Sequence comparison of the amino acid sequence of Chit62J4, determined during bacterial genome sequencing, characterizes the enzyme as a family 18 glycosyl hydrolase with a four-domain structure.
34641521	3	36	theme	human	517:521	arg1	tract					534:538	the human intestinal tract	513:538	the human intestinal tract when supplied with chitin	513:564	This major chitinase, securing nutrition of the bacterium in the human intestinal tract when supplied with chitin, has a pH optimum of 5.5 and processes pNGG with Km = 0.24 mM and kcat = 30.0 s-1.
34641521	1	37	theme	4-nitrophenyl	266:278	arg1	N					280:280	4-nitrophenyl N	266:280	4-nitrophenyl N	266:280	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	1	38	theme	extracellular	179:191	arg1	Chit62J4					243:250	a 62 kDa chitinase Chit62J4	224:250	a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N	224:280	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	1	38	theme	extracellular	179:191	arg1	enzymes					206:212	several extracellular chitinolytic enzymes	171:212	several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG)	171:316	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	8	39	theme	commensal	1462:1470	arg1	bacteria					1472:1479	other commensal bacteria	1456:1479	other commensal bacteria	1456:1479	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	4	40	theme	Sequence	649:656	arg1	comparison					658:667	Sequence comparison	649:667	Sequence comparison	649:667	Sequence comparison of the amino acid sequence of Chit62J4, determined during bacterial genome sequencing, characterizes the enzyme as a family 18 glycosyl hydrolase with a four-domain structure.
34641521	6	41	theme	NCTU2	1120:1124	arg1	chitinase					1091:1099	a single-domain chitinase	1075:1099	a single-domain chitinase of Bacillus cereus NCTU2	1075:1124	The catalytic domain is highly homologous to a single-domain chitinase of Bacillus cereus NCTU2.
34641521	2	42	from	fluid	376:380	arg1	enzyme					346:351	the crude enzyme	336:351	the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat	336:449	We characterized the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat.
34641521	6	43	theme	Bacillus	1104:1111	arg1	NCTU2					1120:1124	Bacillus cereus NCTU2	1104:1124	Bacillus cereus NCTU2	1104:1124	The catalytic domain is highly homologous to a single-domain chitinase of Bacillus cereus NCTU2.
34641521	8	44	theme	competitive	1429:1439	arg1	advantage					1441:1449	a competitive advantage	1427:1449	a competitive advantage over other commensal bacteria	1427:1479	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	3	45	theme	pH	573:574	arg1	optimum					576:582	a pH optimum	571:582	a pH optimum of 5.5 and processes pNGG	571:608	This major chitinase, securing nutrition of the bacterium in the human intestinal tract when supplied with chitin, has a pH optimum of 5.5 and processes pNGG with Km = 0.24 mM and kcat = 30.0 s-1.
34641521	8	46	dep	C.	1406:1407	arg1	paraputrificum					1409:1422	paraputrificum	1409:1422	paraputrificum	1409:1422	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	2	47	from	rChit62J4	402:410	arg1	enzyme					346:351	the crude enzyme	336:351	the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat	336:449	We characterized the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat.
34641521	8	48	theme	pI	1259:1260	arg1	shift					1250:1254	The shift	1246:1254	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium	1246:1351	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	8	48	theme	pI	1259:1260	arg1	adaptation					1381:1390	the likely environmental adaptation	1356:1390	the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria	1356:1479	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	2	49	theme	bacterial	358:366	arg1	fluid					376:380	bacterial culture fluid	358:380	bacterial culture fluid	358:380	We characterized the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat.
34641521	1	50	theme	62	226:227	arg1	kDa					229:231	kDa	229:231	kDa	229:231	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	8	51	theme	pH	1266:1267	arg1	optimum					1269:1275	pH optimum	1266:1275	pH optimum	1266:1275	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	1	52	theme	chitinase	233:241	arg1	Chit62J4					243:250	a 62 kDa chitinase Chit62J4	224:250	a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N	224:280	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	1	52	theme	chitinase	233:241	arg1	β-d-chitobioside					294:309	N'-diacetyl-β-d-chitobioside	282:309	N'-diacetyl-β-d-chitobioside (pNGG)	282:316	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	8	53	theme	soil	1338:1341	arg1	bacterium					1343:1351	the soil bacterium	1334:1351	the soil bacterium	1334:1351	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	5	54	theme	typical	874:880	arg1	structure					893:901	the typical TIM barrel structure	870:901	the typical TIM barrel structure	870:901	The catalytic domain has the typical TIM barrel structure and the accessory domains-2x Fn3/Big3 and a carbohydrate binding module-that likely supports enzyme activity on chitin fibers.
34641521	1	55	theme	active	252:257	arg1	Chit62J4					243:250	a 62 kDa chitinase Chit62J4	224:250	a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N	224:280	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	1	55	theme	active	252:257	arg1	β-d-chitobioside					294:309	N'-diacetyl-β-d-chitobioside	282:309	N'-diacetyl-β-d-chitobioside (pNGG)	282:316	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	8	56	theme	commensal	1284:1292	arg1	enzyme					1294:1299	the commensal enzyme	1280:1299	the commensal enzyme	1280:1299	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	3	57	theme	pNGG	605:608	arg1	optimum					576:582	a pH optimum	571:582	a pH optimum of 5.5 and processes pNGG	571:608	This major chitinase, securing nutrition of the bacterium in the human intestinal tract when supplied with chitin, has a pH optimum of 5.5 and processes pNGG with Km = 0.24 mM and kcat = 30.0 s-1.
34641521	1	58	theme	Clostridium	132:142	arg1	J4					159:160	Commensal bacterium Clostridium paraputrificum J4	112:160	Commensal bacterium Clostridium paraputrificum J4	112:160	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	4	59	theme	Chit62J4	699:706	arg1	sequence					687:694	the amino acid sequence	672:694	the amino acid sequence of Chit62J4	672:706	Sequence comparison of the amino acid sequence of Chit62J4, determined during bacterial genome sequencing, characterizes the enzyme as a family 18 glycosyl hydrolase with a four-domain structure.
34641521	5	60	theme	domains-2x	921:930	arg1	Fn3/Big3					932:939	the accessory domains-2x Fn3/Big3	907:939	the accessory domains-2x Fn3/Big3	907:939	The catalytic domain has the typical TIM barrel structure and the accessory domains-2x Fn3/Big3 and a carbohydrate binding module-that likely supports enzyme activity on chitin fibers.
34641521	0	61	theme	Bacterium	71:79	arg1	J4					108:109	Human Microbiome Bacterium Clostridium paraputrificum J4	54:109	Human Microbiome Bacterium Clostridium paraputrificum J4	54:109	Chitinase Chit62J4 Essential for Chitin Processing by Human Microbiome Bacterium Clostridium paraputrificum J4.
34641521	5	62	theme	TIM	882:884	arg1	structure					893:901	the typical TIM barrel structure	870:901	the typical TIM barrel structure	870:901	The catalytic domain has the typical TIM barrel structure and the accessory domains-2x Fn3/Big3 and a carbohydrate binding module-that likely supports enzyme activity on chitin fibers.
34641521	4	63	theme	amino	676:680	arg1	sequence					687:694	the amino acid sequence	672:694	the amino acid sequence of Chit62J4	672:706	Sequence comparison of the amino acid sequence of Chit62J4, determined during bacterial genome sequencing, characterizes the enzyme as a family 18 glycosyl hydrolase with a four-domain structure.
34641521	4	64	with	hydrolase	805:813	arg1	structure					834:842	a four-domain structure	820:842	a four-domain structure	820:842	Sequence comparison of the amino acid sequence of Chit62J4, determined during bacterial genome sequencing, characterizes the enzyme as a family 18 glycosyl hydrolase with a four-domain structure.
34641521	0	65	theme	paraputrificum	93:106	arg1	J4					108:109	Human Microbiome Bacterium Clostridium paraputrificum J4	54:109	Human Microbiome Bacterium Clostridium paraputrificum J4	54:109	Chitinase Chit62J4 Essential for Chitin Processing by Human Microbiome Bacterium Clostridium paraputrificum J4.
34641521	1	66	theme	chitinolytic	193:204	arg1	Chit62J4					243:250	a 62 kDa chitinase Chit62J4	224:250	a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N	224:280	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	1	66	theme	chitinolytic	193:204	arg1	enzymes					206:212	several extracellular chitinolytic enzymes	171:212	several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG)	171:316	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	4	67	theme	sequence	687:694	arg1	comparison					658:667	Sequence comparison	649:667	Sequence comparison	649:667	Sequence comparison of the amino acid sequence of Chit62J4, determined during bacterial genome sequencing, characterizes the enzyme as a family 18 glycosyl hydrolase with a four-domain structure.
34641521	7	68	theme	catalytic	1229:1237	arg1	sites					1239:1243	almost identical catalytic sites	1212:1243	almost identical catalytic sites	1212:1243	However, the catalytic profiles significantly differ between the two enzymes despite almost identical catalytic sites.
34641521	3	69	theme	5.5	587:589	arg1	pNGG					605:608	5.5 and processes pNGG	587:608	5.5 and processes pNGG	587:608	This major chitinase, securing nutrition of the bacterium in the human intestinal tract when supplied with chitin, has a pH optimum of 5.5 and processes pNGG with Km = 0.24 mM and kcat = 30.0 s-1.
34641521	5	70	contain	has	866:868	arg1	domain					859:864	The catalytic domain	845:864	The catalytic domain	845:864	The catalytic domain has the typical TIM barrel structure and the accessory domains-2x Fn3/Big3 and a carbohydrate binding module-that likely supports enzyme activity on chitin fibers.
34641521	5	70	contain	has	866:868	arg2	structure					893:901	the typical TIM barrel structure	870:901	the typical TIM barrel structure	870:901	The catalytic domain has the typical TIM barrel structure and the accessory domains-2x Fn3/Big3 and a carbohydrate binding module-that likely supports enzyme activity on chitin fibers.
34641521	2	71	theme	culture	368:374	arg1	fluid					376:380	bacterial culture fluid	358:380	bacterial culture fluid	358:380	We characterized the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat.
34641521	8	72	theme	likely	1360:1365	arg1	shift					1250:1254	The shift	1246:1254	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium	1246:1351	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	8	72	theme	likely	1360:1365	arg1	adaptation					1381:1390	the likely environmental adaptation	1356:1390	the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria	1356:1479	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	6	73	theme	single-domain	1077:1089	arg1	chitinase					1091:1099	a single-domain chitinase	1075:1099	a single-domain chitinase of Bacillus cereus NCTU2	1075:1124	The catalytic domain is highly homologous to a single-domain chitinase of Bacillus cereus NCTU2.
34641521	4	74	theme	bacterial	727:735	arg1	sequencing					744:753	bacterial genome sequencing	727:753	bacterial genome sequencing	727:753	Sequence comparison of the amino acid sequence of Chit62J4, determined during bacterial genome sequencing, characterizes the enzyme as a family 18 glycosyl hydrolase with a four-domain structure.
34641521	4	75	theme	glycosyl	796:803	arg1	enzyme					774:779	the enzyme	770:779	the enzyme	770:779	Sequence comparison of the amino acid sequence of Chit62J4, determined during bacterial genome sequencing, characterizes the enzyme as a family 18 glycosyl hydrolase with a four-domain structure.
34641521	4	75	theme	glycosyl	796:803	arg1	hydrolase					805:813	a family 18 glycosyl hydrolase	784:813	a family 18 glycosyl hydrolase with a four-domain structure	784:842	Sequence comparison of the amino acid sequence of Chit62J4, determined during bacterial genome sequencing, characterizes the enzyme as a family 18 glycosyl hydrolase with a four-domain structure.
34641521	1	76	theme	Commensal	112:120	arg1	J4					159:160	Commensal bacterium Clostridium paraputrificum J4	112:160	Commensal bacterium Clostridium paraputrificum J4	112:160	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	6	77	dep	Bacillus	1104:1111	arg1	cereus					1113:1118	cereus	1113:1118	cereus	1113:1118	The catalytic domain is highly homologous to a single-domain chitinase of Bacillus cereus NCTU2.
34641521	3	78	theme	bacterium	500:508	arg1	nutrition					483:491	nutrition	483:491	nutrition of the bacterium in the human intestinal tract when supplied with chitin	483:564	This major chitinase, securing nutrition of the bacterium in the human intestinal tract when supplied with chitin, has a pH optimum of 5.5 and processes pNGG with Km = 0.24 mM and kcat = 30.0 s-1.
34641521	0	79	theme	Human	54:58	arg1	J4					108:109	Human Microbiome Bacterium Clostridium paraputrificum J4	54:109	Human Microbiome Bacterium Clostridium paraputrificum J4	54:109	Chitinase Chit62J4 Essential for Chitin Processing by Human Microbiome Bacterium Clostridium paraputrificum J4.
34641521	2	80	from	domain	431:436	arg1	enzyme					346:351	the crude enzyme	336:351	the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat	336:449	We characterized the crude enzyme from bacterial culture fluid, recombinant enzyme rChit62J4, and its catalytic domain rChit62J4cat.
34641521	3	81	theme	intestinal	523:532	arg1	tract					534:538	the human intestinal tract	513:538	the human intestinal tract when supplied with chitin	513:564	This major chitinase, securing nutrition of the bacterium in the human intestinal tract when supplied with chitin, has a pH optimum of 5.5 and processes pNGG with Km = 0.24 mM and kcat = 30.0 s-1.
34641521	5	82	theme	chitin	1015:1020	arg1	fibers					1022:1027	chitin fibers	1015:1027	chitin fibers	1015:1027	The catalytic domain has the typical TIM barrel structure and the accessory domains-2x Fn3/Big3 and a carbohydrate binding module-that likely supports enzyme activity on chitin fibers.
34641521	8	83	theme	other	1456:1460	arg1	bacteria					1472:1479	other commensal bacteria	1456:1479	other commensal bacteria	1456:1479	The shift of pI and pH optimum of the commensal enzyme toward acidic values compared to the soil bacterium is the likely environmental adaptation that provides C. paraputrificum J4 a competitive advantage over other commensal bacteria.
34641521	3	84	from	nutrition	483:491	arg1	tract					534:538	the human intestinal tract	513:538	the human intestinal tract when supplied with chitin	513:564	This major chitinase, securing nutrition of the bacterium in the human intestinal tract when supplied with chitin, has a pH optimum of 5.5 and processes pNGG with Km = 0.24 mM and kcat = 30.0 s-1.
34641521	1	85	theme	N'-diacetyl-	282:293	arg1	Chit62J4					243:250	a 62 kDa chitinase Chit62J4	224:250	a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N	224:280	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	1	85	theme	N'-diacetyl-	282:293	arg1	pNGG					312:315	pNGG	312:315	pNGG	312:315	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34641521	1	85	theme	N'-diacetyl-	282:293	arg1	β-d-chitobioside					294:309	N'-diacetyl-β-d-chitobioside	282:309	N'-diacetyl-β-d-chitobioside (pNGG)	282:316	Commensal bacterium Clostridium paraputrificum J4 produces several extracellular chitinolytic enzymes including a 62 kDa chitinase Chit62J4 active toward 4-nitrophenyl N,N'-diacetyl-β-d-chitobioside (pNGG).
34582908	7	0	theme	AS/IC	1565:1569	arg1	material					1581:1588	the AS/IC composite material	1561:1588	the AS/IC composite material	1561:1588	Finally, AS/IC-BEF samples successfully inhibited weight loss of cherry tomatoes at room temperature and extended their shelf life to 10 days, which indicated that the AS/IC composite material produced a BEF with potential food and industrial applications.
34582908	4	1	theme	barrier	952:958	arg1	properties					960:969	barrier properties	952:969	barrier properties	952:969	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	4	2	theme	tensile	891:897	arg1	strength					899:906	higher tensile strength	884:906	higher tensile strength	884:906	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	4	3	from	surface	765:771	arg1	7 days					841:846	7 days	841:846	7 days	841:846	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	4	4	theme	smooth	758:763	arg1	surface					765:771	smooth surface	758:771	smooth surface	758:771	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	1	5	theme	other	269:273	arg1	hydrocolloids					275:287	other hydrocolloids	269:287	other hydrocolloids	269:287	Future food packaging trends are shifting to natural and eco-friendly materials developed from biopolymers such as starch and other hydrocolloids, to reduce pollution from synthetic polymers.
34582908	4	6	theme	composting	807:816	arg1	biodegradation					823:836	completed composting soil biodegradation	797:836	completed composting soil biodegradation	797:836	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	4	7	theme	high	774:777	arg1	transparency					779:790	high transparency	774:790	high transparency	774:790	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	1	8	from	polymers	325:332	arg1	pollution					300:308	pollution	300:308	pollution from synthetic polymers	300:332	Future food packaging trends are shifting to natural and eco-friendly materials developed from biopolymers such as starch and other hydrocolloids, to reduce pollution from synthetic polymers.
34582908	7	9	theme	industrial	1629:1638	arg1	applications					1640:1651	potential food and industrial applications	1610:1651	potential food and industrial applications	1610:1651	Finally, AS/IC-BEF samples successfully inhibited weight loss of cherry tomatoes at room temperature and extended their shelf life to 10 days, which indicated that the AS/IC composite material produced a BEF with potential food and industrial applications.
34582908	5	10	theme	strong	1130:1135	arg1	interactions					1151:1162	strong hydrogen bond interactions	1130:1162	strong hydrogen bond interactions between polymers	1130:1179	XRD analysis indicated IC fractions contributed to increase in degree of crystallinity (28.35°) and FTIR signaled strong hydrogen bond interactions between polymers.
34582908	3	11	theme	barrier	608:614	arg1	properties					616:625	their physico-mechanical and barrier properties	579:625	properties	616:625	All films were characterized based on their physico-mechanical and barrier properties, functional group properties, crystallinity properties, thermal properties, and soil and seawater biodegradation.
34582908	4	12	theme	AS/IC-BEF	856:864	arg1	samples					866:872	AS/IC-BEF samples	856:872	AS/IC-BEF samples	856:872	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	4	13	theme	water	909:913	arg1	solubility					915:924	water solubility	909:924	water solubility	909:924	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	7	14	theme	food	1620:1623	arg1	applications					1640:1651	potential food and industrial applications	1610:1651	potential food and industrial applications	1610:1651	Finally, AS/IC-BEF samples successfully inhibited weight loss of cherry tomatoes at room temperature and extended their shelf life to 10 days, which indicated that the AS/IC composite material produced a BEF with potential food and industrial applications.
34582908	6	15	theme	melting	1375:1381	arg1	temperatures					1383:1394	melting temperatures	1375:1394	melting temperatures	1375:1394	AS/IC-BEF samples demonstrated melting temperatures between 158 and 190 °C while glass transition temperatures ranged from 153 to 176 °C, which resulted in maximum weight loss around 50-55% at melting temperatures.
34582908	4	16	theme	higher	884:889	arg1	strength					899:906	higher tensile strength	884:906	higher tensile strength	884:906	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	2	17	theme	Arrowroot	335:343	arg1	IC					401:402	IC	401:402	IC	401:402	Arrowroot starch (AS) (3.5, 3, 2.5, and 2%) and iota-carrageenan (IC) (0.5, 1, 1.5, and 2%) were blended to develop biodegradable edible films (AS/IC-BEF), which were compared against AS-BEF (4%, control).
34582908	2	17	theme	Arrowroot	335:343	arg1	%					376:376	3.5, 3, 2.5, and 2%	358:376	3.5, 3, 2.5, and 2%	358:376	Arrowroot starch (AS) (3.5, 3, 2.5, and 2%) and iota-carrageenan (IC) (0.5, 1, 1.5, and 2%) were blended to develop biodegradable edible films (AS/IC-BEF), which were compared against AS-BEF (4%, control).
34582908	2	17	theme	Arrowroot	335:343	arg1	starch					345:350	Arrowroot starch	335:350	Arrowroot starch (AS) (3.5, 3, 2.5, and 2%)	335:377	Arrowroot starch (AS) (3.5, 3, 2.5, and 2%) and iota-carrageenan (IC) (0.5, 1, 1.5, and 2%) were blended to develop biodegradable edible films (AS/IC-BEF), which were compared against AS-BEF (4%, control).
34582908	2	17	theme	Arrowroot	335:343	arg1	%					424:424	0.5, 1, 1.5, and 2%	406:424	0.5, 1, 1.5, and 2%	406:424	Arrowroot starch (AS) (3.5, 3, 2.5, and 2%) and iota-carrageenan (IC) (0.5, 1, 1.5, and 2%) were blended to develop biodegradable edible films (AS/IC-BEF), which were compared against AS-BEF (4%, control).
34582908	5	18	theme	XRD	1016:1018	arg1	analysis					1020:1027	XRD analysis	1016:1027	XRD analysis	1016:1027	XRD analysis indicated IC fractions contributed to increase in degree of crystallinity (28.35°) and FTIR signaled strong hydrogen bond interactions between polymers.
34582908	1	19	theme	natural	188:194	arg1	materials					213:221	natural and eco-friendly materials	188:221	natural and eco-friendly materials developed from biopolymers such as starch and other hydrocolloids	188:287	Future food packaging trends are shifting to natural and eco-friendly materials developed from biopolymers such as starch and other hydrocolloids, to reduce pollution from synthetic polymers.
34582908	4	20	theme	swelling	927:934	arg1	properties					936:945	swelling properties	927:945	swelling properties	927:945	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	3	21	theme	functional	628:637	arg1	properties					645:654	functional group properties	628:654	functional group properties	628:654	All films were characterized based on their physico-mechanical and barrier properties, functional group properties, crystallinity properties, thermal properties, and soil and seawater biodegradation.
34582908	4	22	from	transparency	779:790	arg1	7 days					841:846	7 days	841:846	7 days	841:846	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	2	23	dep	starch	345:350	arg1	AS					353:354	AS	353:354	AS	353:354	Arrowroot starch (AS) (3.5, 3, 2.5, and 2%) and iota-carrageenan (IC) (0.5, 1, 1.5, and 2%) were blended to develop biodegradable edible films (AS/IC-BEF), which were compared against AS-BEF (4%, control).
34582908	4	24	from	biodegradation	823:836	arg1	7 days					841:846	7 days	841:846	7 days	841:846	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	0	25	theme	natural	22:28	arg1	film					51:54	a natural biodegradable edible film	20:54	a natural biodegradable edible film	20:54	Characterization of a natural biodegradable edible film obtained from arrowroot starch and iota-carrageenan and application in food packaging.
34582908	3	26	theme	group	639:643	arg1	properties					645:654	functional group properties	628:654	functional group properties	628:654	All films were characterized based on their physico-mechanical and barrier properties, functional group properties, crystallinity properties, thermal properties, and soil and seawater biodegradation.
34582908	2	27	theme	biodegradable	451:463	arg1	films					472:476	biodegradable edible films	451:476	biodegradable edible films (AS/IC-BEF)	451:488	Arrowroot starch (AS) (3.5, 3, 2.5, and 2%) and iota-carrageenan (IC) (0.5, 1, 1.5, and 2%) were blended to develop biodegradable edible films (AS/IC-BEF), which were compared against AS-BEF (4%, control).
34582908	2	27	theme	biodegradable	451:463	arg1	AS/IC-BEF					479:487	AS/IC-BEF	479:487	AS/IC-BEF	479:487	Arrowroot starch (AS) (3.5, 3, 2.5, and 2%) and iota-carrageenan (IC) (0.5, 1, 1.5, and 2%) were blended to develop biodegradable edible films (AS/IC-BEF), which were compared against AS-BEF (4%, control).
34582908	7	28	theme	potential	1610:1618	arg1	applications					1640:1651	potential food and industrial applications	1610:1651	potential food and industrial applications	1610:1651	Finally, AS/IC-BEF samples successfully inhibited weight loss of cherry tomatoes at room temperature and extended their shelf life to 10 days, which indicated that the AS/IC composite material produced a BEF with potential food and industrial applications.
34582908	1	29	theme	eco-friendly	200:211	arg1	materials					213:221	natural and eco-friendly materials	188:221	natural and eco-friendly materials developed from biopolymers such as starch and other hydrocolloids	188:287	Future food packaging trends are shifting to natural and eco-friendly materials developed from biopolymers such as starch and other hydrocolloids, to reduce pollution from synthetic polymers.
34582908	7	30	theme	shelf	1517:1521	arg1	life					1523:1526	their shelf life	1511:1526	their shelf life	1511:1526	Finally, AS/IC-BEF samples successfully inhibited weight loss of cherry tomatoes at room temperature and extended their shelf life to 10 days, which indicated that the AS/IC composite material produced a BEF with potential food and industrial applications.
34582908	0	31	theme	food	127:130	arg1	packaging					132:140	food packaging	127:140	food packaging	127:140	Characterization of a natural biodegradable edible film obtained from arrowroot starch and iota-carrageenan and application in food packaging.
34582908	7	32	theme	room	1481:1484	arg1	temperature					1486:1496	room temperature	1481:1496	room temperature	1481:1496	Finally, AS/IC-BEF samples successfully inhibited weight loss of cherry tomatoes at room temperature and extended their shelf life to 10 days, which indicated that the AS/IC composite material produced a BEF with potential food and industrial applications.
34582908	0	33	theme	edible	44:49	arg1	film					51:54	a natural biodegradable edible film	20:54	a natural biodegradable edible film	20:54	Characterization of a natural biodegradable edible film obtained from arrowroot starch and iota-carrageenan and application in food packaging.
34582908	7	34	theme	composite	1571:1579	arg1	material					1581:1588	the AS/IC composite material	1561:1588	the AS/IC composite material	1561:1588	Finally, AS/IC-BEF samples successfully inhibited weight loss of cherry tomatoes at room temperature and extended their shelf life to 10 days, which indicated that the AS/IC composite material produced a BEF with potential food and industrial applications.
34582908	6	35	theme	transition	1269:1278	arg1	temperatures					1280:1291	glass transition temperatures	1263:1291	glass transition temperatures	1263:1291	AS/IC-BEF samples demonstrated melting temperatures between 158 and 190 °C while glass transition temperatures ranged from 153 to 176 °C, which resulted in maximum weight loss around 50-55% at melting temperatures.
34582908	0	36	from	starch	80:85	arg1	packaging					132:140	food packaging	127:140	food packaging	127:140	Characterization of a natural biodegradable edible film obtained from arrowroot starch and iota-carrageenan and application in food packaging.
34582908	7	37	theme	cherry	1462:1467	arg1	tomatoes					1469:1476	cherry tomatoes	1462:1476	cherry tomatoes	1462:1476	Finally, AS/IC-BEF samples successfully inhibited weight loss of cherry tomatoes at room temperature and extended their shelf life to 10 days, which indicated that the AS/IC composite material produced a BEF with potential food and industrial applications.
34582908	6	38	theme	AS/IC-BEF	1182:1190	arg1	samples					1192:1198	AS/IC-BEF samples	1182:1198	AS/IC-BEF samples	1182:1198	AS/IC-BEF samples demonstrated melting temperatures between 158 and 190 °C while glass transition temperatures ranged from 153 to 176 °C, which resulted in maximum weight loss around 50-55% at melting temperatures.
34582908	1	39	theme	synthetic	315:323	arg1	polymers					325:332	synthetic polymers	315:332	synthetic polymers	315:332	Future food packaging trends are shifting to natural and eco-friendly materials developed from biopolymers such as starch and other hydrocolloids, to reduce pollution from synthetic polymers.
34582908	5	40	theme	FTIR	1116:1119	arg1	degree					1079:1084	degree	1079:1084	degree of crystallinity (28.35°) and FTIR	1079:1119	XRD analysis indicated IC fractions contributed to increase in degree of crystallinity (28.35°) and FTIR signaled strong hydrogen bond interactions between polymers.
34582908	7	41	theme	tomatoes	1469:1476	arg1	loss					1454:1457	weight loss	1447:1457	weight loss of cherry tomatoes	1447:1476	Finally, AS/IC-BEF samples successfully inhibited weight loss of cherry tomatoes at room temperature and extended their shelf life to 10 days, which indicated that the AS/IC composite material produced a BEF with potential food and industrial applications.
34582908	7	42	theme	AS/IC-BEF	1406:1414	arg1	samples					1416:1422	AS/IC-BEF samples	1406:1422	AS/IC-BEF samples	1406:1422	Finally, AS/IC-BEF samples successfully inhibited weight loss of cherry tomatoes at room temperature and extended their shelf life to 10 days, which indicated that the AS/IC composite material produced a BEF with potential food and industrial applications.
34582908	6	43	theme	weight	1346:1351	arg1	loss					1353:1356	maximum weight loss	1338:1356	maximum weight loss around 50-55% at melting temperatures	1338:1394	AS/IC-BEF samples demonstrated melting temperatures between 158 and 190 °C while glass transition temperatures ranged from 153 to 176 °C, which resulted in maximum weight loss around 50-55% at melting temperatures.
34582908	3	44	theme	crystallinity	657:669	arg1	properties					671:680	crystallinity properties	657:680	crystallinity properties	657:680	All films were characterized based on their physico-mechanical and barrier properties, functional group properties, crystallinity properties, thermal properties, and soil and seawater biodegradation.
34582908	7	45	with	BEF	1601:1603	arg1	applications					1640:1651	potential food and industrial applications	1610:1651	potential food and industrial applications	1610:1651	Finally, AS/IC-BEF samples successfully inhibited weight loss of cherry tomatoes at room temperature and extended their shelf life to 10 days, which indicated that the AS/IC composite material produced a BEF with potential food and industrial applications.
34582908	0	46	theme	film	51:54	arg1	Characterization					0:15	Characterization	0:15	Characterization of a natural biodegradable edible film	0:54	Characterization of a natural biodegradable edible film obtained from arrowroot starch and iota-carrageenan and application in food packaging.
34582908	4	47	theme	soil	818:821	arg1	biodegradation					823:836	completed composting soil biodegradation	797:836	completed composting soil biodegradation	797:836	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	3	48	dep	soil	707:710	arg1	biodegradation					725:738	biodegradation	725:738	biodegradation	725:738	All films were characterized based on their physico-mechanical and barrier properties, functional group properties, crystallinity properties, thermal properties, and soil and seawater biodegradation.
34582908	6	49	theme	melting	1213:1219	arg1	temperatures					1221:1232	melting temperatures	1213:1232	melting temperatures between 158 and 190 °C	1213:1255	AS/IC-BEF samples demonstrated melting temperatures between 158 and 190 °C while glass transition temperatures ranged from 153 to 176 °C, which resulted in maximum weight loss around 50-55% at melting temperatures.
34582908	6	50	dep	176 °C	1312:1317	arg1	to					1309:1310	to	1309:1310	to	1309:1310	AS/IC-BEF samples demonstrated melting temperatures between 158 and 190 °C while glass transition temperatures ranged from 153 to 176 °C, which resulted in maximum weight loss around 50-55% at melting temperatures.
34582908	4	51	theme	completed	797:805	arg1	biodegradation					823:836	completed composting soil biodegradation	797:836	completed composting soil biodegradation	797:836	AS-BEF exhibited smooth surface, high transparency, and completed composting soil biodegradation in 7 days whereas AS/IC-BEF samples exhibited higher tensile strength, water solubility, swelling properties, and barrier properties, but completed biodegradation after 30 days.
34582908	0	52	from	application	112:122	arg1	packaging					132:140	food packaging	127:140	food packaging	127:140	Characterization of a natural biodegradable edible film obtained from arrowroot starch and iota-carrageenan and application in food packaging.
34582908	0	53	dep	natural	22:28	arg1	biodegradable					30:42	biodegradable	30:42	biodegradable	30:42	Characterization of a natural biodegradable edible film obtained from arrowroot starch and iota-carrageenan and application in food packaging.
34582908	6	54	theme	glass	1263:1267	arg1	temperatures					1280:1291	glass transition temperatures	1263:1291	glass transition temperatures	1263:1291	AS/IC-BEF samples demonstrated melting temperatures between 158 and 190 °C while glass transition temperatures ranged from 153 to 176 °C, which resulted in maximum weight loss around 50-55% at melting temperatures.
34582908	5	55	theme	hydrogen	1137:1144	arg1	interactions					1151:1162	strong hydrogen bond interactions	1130:1162	strong hydrogen bond interactions between polymers	1130:1179	XRD analysis indicated IC fractions contributed to increase in degree of crystallinity (28.35°) and FTIR signaled strong hydrogen bond interactions between polymers.
34582908	2	56	theme	edible	465:470	arg1	films					472:476	biodegradable edible films	451:476	biodegradable edible films (AS/IC-BEF)	451:488	Arrowroot starch (AS) (3.5, 3, 2.5, and 2%) and iota-carrageenan (IC) (0.5, 1, 1.5, and 2%) were blended to develop biodegradable edible films (AS/IC-BEF), which were compared against AS-BEF (4%, control).
34582908	2	56	theme	edible	465:470	arg1	AS/IC-BEF					479:487	AS/IC-BEF	479:487	AS/IC-BEF	479:487	Arrowroot starch (AS) (3.5, 3, 2.5, and 2%) and iota-carrageenan (IC) (0.5, 1, 1.5, and 2%) were blended to develop biodegradable edible films (AS/IC-BEF), which were compared against AS-BEF (4%, control).
34582908	7	57	theme	weight	1447:1452	arg1	loss					1454:1457	weight loss	1447:1457	weight loss of cherry tomatoes	1447:1476	Finally, AS/IC-BEF samples successfully inhibited weight loss of cherry tomatoes at room temperature and extended their shelf life to 10 days, which indicated that the AS/IC composite material produced a BEF with potential food and industrial applications.
34582908	6	58	from	temperatures	1383:1394	arg1	%					1370:1370	50-55%	1365:1370	50-55% at melting temperatures	1365:1394	AS/IC-BEF samples demonstrated melting temperatures between 158 and 190 °C while glass transition temperatures ranged from 153 to 176 °C, which resulted in maximum weight loss around 50-55% at melting temperatures.
34582908	1	59	theme	Future	143:148	arg1	trends					165:170	Future food packaging trends	143:170	Future food packaging trends	143:170	Future food packaging trends are shifting to natural and eco-friendly materials developed from biopolymers such as starch and other hydrocolloids, to reduce pollution from synthetic polymers.
34582908	5	60	theme	bond	1146:1149	arg1	interactions					1151:1162	strong hydrogen bond interactions	1130:1162	strong hydrogen bond interactions between polymers	1130:1179	XRD analysis indicated IC fractions contributed to increase in degree of crystallinity (28.35°) and FTIR signaled strong hydrogen bond interactions between polymers.
34582908	0	61	theme	arrowroot	70:78	arg1	starch					80:85	arrowroot starch	70:85	arrowroot starch	70:85	Characterization of a natural biodegradable edible film obtained from arrowroot starch and iota-carrageenan and application in food packaging.
34582908	0	62	from	iota-carrageenan	91:106	arg1	packaging					132:140	food packaging	127:140	food packaging	127:140	Characterization of a natural biodegradable edible film obtained from arrowroot starch and iota-carrageenan and application in food packaging.
34582908	1	63	theme	food	150:153	arg1	trends					165:170	Future food packaging trends	143:170	Future food packaging trends	143:170	Future food packaging trends are shifting to natural and eco-friendly materials developed from biopolymers such as starch and other hydrocolloids, to reduce pollution from synthetic polymers.
34582908	5	64	theme	crystallinity	1089:1101	arg1	degree					1079:1084	degree	1079:1084	degree of crystallinity (28.35°) and FTIR	1079:1119	XRD analysis indicated IC fractions contributed to increase in degree of crystallinity (28.35°) and FTIR signaled strong hydrogen bond interactions between polymers.
34582908	5	65	theme	IC	1039:1040	arg1	fractions					1042:1050	IC fractions	1039:1050	IC fractions contributed to increase in degree of crystallinity (28.35°) and FTIR signaled strong hydrogen bond interactions between polymers	1039:1179	XRD analysis indicated IC fractions contributed to increase in degree of crystallinity (28.35°) and FTIR signaled strong hydrogen bond interactions between polymers.
34582908	6	66	theme	maximum	1338:1344	arg1	loss					1353:1356	maximum weight loss	1338:1356	maximum weight loss around 50-55% at melting temperatures	1338:1394	AS/IC-BEF samples demonstrated melting temperatures between 158 and 190 °C while glass transition temperatures ranged from 153 to 176 °C, which resulted in maximum weight loss around 50-55% at melting temperatures.
34582908	1	67	theme	packaging	155:163	arg1	trends					165:170	Future food packaging trends	143:170	Future food packaging trends	143:170	Future food packaging trends are shifting to natural and eco-friendly materials developed from biopolymers such as starch and other hydrocolloids, to reduce pollution from synthetic polymers.
34582908	2	68	dep	%	528:528	arg1	control					531:537	control	531:537	control	531:537	Arrowroot starch (AS) (3.5, 3, 2.5, and 2%) and iota-carrageenan (IC) (0.5, 1, 1.5, and 2%) were blended to develop biodegradable edible films (AS/IC-BEF), which were compared against AS-BEF (4%, control).
34582908	3	69	theme	thermal	683:689	arg1	properties					691:700	thermal properties	683:700	thermal properties	683:700	All films were characterized based on their physico-mechanical and barrier properties, functional group properties, crystallinity properties, thermal properties, and soil and seawater biodegradation.
33376510	0	0	theme	N-glycan	94:101	arg1	alteration					103:112	N-glycan alteration	94:112	N-glycan alteration of organic cation transporter member 2	94:151	Silencing GnT-V reduces oxaliplatin chemosensitivity in human colorectal cancer cells through N-glycan alteration of organic cation transporter member 2.
33376510	5	1	theme	drug	752:755	arg1	transporter					757:767	this drug transporter	747:767	this drug transporter	747:767	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	7	2	theme	marked	1050:1055	arg1	reduction					1057:1065	a marked reduction	1048:1065	a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2	1048:1116	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	7	3	theme	OCT2	1152:1155	arg1	localization					1136:1147	the localization	1132:1147	the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells	1132:1285	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	5	4	theme	transporter	757:767	arg1	glycosylation					730:742	the glycosylation	726:742	the glycosylation of this drug transporter	726:767	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	0	5	dep	transporter	132:142	arg1	member					144:149	member 2	144:151	organic cation transporter member 2	117:151	Silencing GnT-V reduces oxaliplatin chemosensitivity in human colorectal cancer cells through N-glycan alteration of organic cation transporter member 2.
33376510	7	6	from	presence	1074:1081	arg1	OCT2					1113:1116	OCT2	1113:1116	OCT2	1113:1116	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	7	7	theme	reduced	1207:1213	arg1	uptake					1215:1220	a reduced uptake	1205:1220	a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells	1205:1285	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	5	8	theme	present	627:633	arg1	study					635:639	The present study	623:639	The present study	623:639	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	4	9	theme	CRC	597:599	arg1	cells					601:605	CRC cells	597:605	CRC cells	597:605	The aim of the present study was to better understand the mechanism underlying the chemosensitivity of CRC cells to oxaliplatin.
33376510	7	10	theme	oxaliplatin	1225:1235	arg1	uptake					1215:1220	a reduced uptake	1205:1220	a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells	1205:1285	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	2	11	used	used	353:356	arg2	Oxaliplatin					314:324	Oxaliplatin	314:324	Oxaliplatin	314:324	Oxaliplatin, a platinum-based drug, is used for the chemotherapy of colorectal cancer (CRC).
33376510	2	11	used	used	353:356	arg2	drug					344:347	a platinum-based drug	327:347	a platinum-based drug	327:347	Oxaliplatin, a platinum-based drug, is used for the chemotherapy of colorectal cancer (CRC).
33376510	0	12	theme	cation	125:130	arg1	transporter					132:142	organic cation transporter member 2	117:151	organic cation transporter member 2	117:151	Silencing GnT-V reduces oxaliplatin chemosensitivity in human colorectal cancer cells through N-glycan alteration of organic cation transporter member 2.
33376510	5	13	theme	residues	838:845	arg1	sensitivity					704:714	oxaliplatin sensitivity	692:714	oxaliplatin sensitivity involving the glycosylation of this drug transporter	692:767	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	5	13	theme	residues	838:845	arg1	modification					787:798	specifically the modification	770:798	specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V)	770:890	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	3	14	theme	major	444:448	arg1	challenge					450:458	a major challenge	442:458	a major challenge in the treatment of advanced CRC	442:491	However, oxaliplatin resistance is a major challenge in the treatment of advanced CRC.
33376510	3	14	theme	major	444:448	arg1	resistance					428:437	oxaliplatin resistance	416:437	oxaliplatin resistance	416:437	However, oxaliplatin resistance is a major challenge in the treatment of advanced CRC.
33376510	2	15	theme	colorectal	382:391	arg1	CRC					401:403	CRC	401:403	CRC	401:403	Oxaliplatin, a platinum-based drug, is used for the chemotherapy of colorectal cancer (CRC).
33376510	2	15	theme	colorectal	382:391	arg1	cancer					393:398	colorectal cancer	382:398	colorectal cancer (CRC)	382:404	Oxaliplatin, a platinum-based drug, is used for the chemotherapy of colorectal cancer (CRC).
33376510	0	16	theme	organic	117:123	arg1	transporter					132:142	organic cation transporter member 2	117:151	organic cation transporter member 2	117:151	Silencing GnT-V reduces oxaliplatin chemosensitivity in human colorectal cancer cells through N-glycan alteration of organic cation transporter member 2.
33376510	3	17	from	challenge	450:458	arg1	treatment					467:475	the treatment	463:475	the treatment of advanced CRC	463:491	However, oxaliplatin resistance is a major challenge in the treatment of advanced CRC.
33376510	5	18	theme	β-1,6-N-acetylglucosamine	803:827	arg1	residues					838:845	β-1,6-N-acetylglucosamine (GlcNAc) residues	803:845	β-1,6-N-acetylglucosamine (GlcNAc) residues	803:845	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	3	19	theme	oxaliplatin	416:426	arg1	challenge					450:458	a major challenge	442:458	a major challenge in the treatment of advanced CRC	442:491	However, oxaliplatin resistance is a major challenge in the treatment of advanced CRC.
33376510	3	19	theme	oxaliplatin	416:426	arg1	resistance					428:437	oxaliplatin resistance	416:437	oxaliplatin resistance	416:437	However, oxaliplatin resistance is a major challenge in the treatment of advanced CRC.
33376510	0	20	from	chemosensitivity	36:51	arg1	cells					80:84	human colorectal cancer cells	56:84	human colorectal cancer cells	56:84	Silencing GnT-V reduces oxaliplatin chemosensitivity in human colorectal cancer cells through N-glycan alteration of organic cation transporter member 2.
33376510	7	21	theme	structures	1099:1108	arg1	presence					1074:1081	the presence	1070:1081	the presence of β-1,6-GlcNAc structures on OCT2	1070:1116	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	6	22	theme	cells	998:1002	arg1	chemosensitivity					973:988	the oxaliplatin chemosensitivity	957:988	the oxaliplatin chemosensitivity of CW-2 cells	957:1002	The results revealed that the downregulation of GnT-V inhibited the oxaliplatin chemosensitivity of CW-2 cells.
33376510	1	23	dep	transporter	169:179	arg1	member					181:186	member 2	181:188	Organic cation transporter member 2 (OCT2)	154:195	Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
33376510	0	24	theme	Silencing	0:8	arg1	GnT-V					10:14	Silencing GnT-V	0:14	Silencing GnT-V	0:14	Silencing GnT-V reduces oxaliplatin chemosensitivity in human colorectal cancer cells through N-glycan alteration of organic cation transporter member 2.
33376510	4	25	theme	study	517:521	arg1	aim					498:500	The aim	494:500	The aim of the present study	494:521	The aim of the present study was to better understand the mechanism underlying the chemosensitivity of CRC cells to oxaliplatin.
33376510	1	26	gly	N-glycosylated	203:216	arg1	transporter					169:179	Organic cation transporter	154:179	Organic cation transporter member 2 (OCT2)	154:195	Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
33376510	1	26	gly	N-glycosylated	203:216	arg1	transporter					218:228	an N-glycosylated transporter	200:228	an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs	200:311	Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
33376510	8	27	theme	CRC	1503:1505	arg1	cells					1507:1511	CRC cells	1503:1511	CRC cells	1503:1511	Overall, the study provides novel insights into the molecular mechanism by which GnT-V regulates the chemosensitivity to oxaliplatin, which involves the modulation of the drug transporter OCT2 by N-glycosylation in CRC cells.
33376510	8	28	gly	N-glycosylation	1484:1498	arg1	cells					1507:1511	CRC cells	1503:1511	CRC cells	1503:1511	Overall, the study provides novel insights into the molecular mechanism by which GnT-V regulates the chemosensitivity to oxaliplatin, which involves the modulation of the drug transporter OCT2 by N-glycosylation in CRC cells.
33376510	0	29	theme	oxaliplatin	24:34	arg1	chemosensitivity					36:51	oxaliplatin chemosensitivity	24:51	oxaliplatin chemosensitivity in human colorectal cancer cells	24:84	Silencing GnT-V reduces oxaliplatin chemosensitivity in human colorectal cancer cells through N-glycan alteration of organic cation transporter member 2.
33376510	4	30	theme	present	509:515	arg1	study					517:521	the present study	505:521	the present study	505:521	The aim of the present study was to better understand the mechanism underlying the chemosensitivity of CRC cells to oxaliplatin.
33376510	5	31	gly	glycosylation	730:742	arg1	transporter					757:767	this drug transporter	747:767	this drug transporter	747:767	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	4	32	theme	cells	601:605	arg1	chemosensitivity					577:592	the chemosensitivity	573:592	the chemosensitivity of CRC cells to oxaliplatin	573:620	The aim of the present study was to better understand the mechanism underlying the chemosensitivity of CRC cells to oxaliplatin.
33376510	5	33	theme	GlcNAc	830:835	arg1	residues					838:845	β-1,6-N-acetylglucosamine (GlcNAc) residues	803:845	β-1,6-N-acetylglucosamine (GlcNAc) residues	803:845	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	7	34	from	OCT2	1113:1116	arg1	presence					1074:1081	the presence	1070:1081	the presence of β-1,6-GlcNAc structures on OCT2	1070:1116	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	0	35	theme	transporter	132:142	arg1	alteration					103:112	N-glycan alteration	94:112	N-glycan alteration of organic cation transporter member 2	94:151	Silencing GnT-V reduces oxaliplatin chemosensitivity in human colorectal cancer cells through N-glycan alteration of organic cation transporter member 2.
33376510	8	36	theme	OCT2	1476:1479	arg1	modulation					1441:1450	the modulation	1437:1450	the modulation of the drug transporter OCT2 by N-glycosylation in CRC cells	1437:1511	Overall, the study provides novel insights into the molecular mechanism by which GnT-V regulates the chemosensitivity to oxaliplatin, which involves the modulation of the drug transporter OCT2 by N-glycosylation in CRC cells.
33376510	3	37	theme	advanced	480:487	arg1	CRC					489:491	advanced CRC	480:491	advanced CRC	480:491	However, oxaliplatin resistance is a major challenge in the treatment of advanced CRC.
33376510	3	38	theme	CRC	489:491	arg1	treatment					467:475	the treatment	463:475	the treatment of advanced CRC	463:491	However, oxaliplatin resistance is a major challenge in the treatment of advanced CRC.
33376510	8	39	theme	molecular	1340:1348	arg1	mechanism					1350:1358	the molecular mechanism	1336:1358	the molecular mechanism by which GnT-V regulates the chemosensitivity to oxaliplatin, which involves the modulation of the drug transporter OCT2 by N-glycosylation in CRC cells	1336:1511	Overall, the study provides novel insights into the molecular mechanism by which GnT-V regulates the chemosensitivity to oxaliplatin, which involves the modulation of the drug transporter OCT2 by N-glycosylation in CRC cells.
33376510	7	40	theme	CW-2	1276:1279	arg1	cells					1281:1285	wild-type and oxaliplatin-resistant CW-2 cells	1240:1285	wild-type and oxaliplatin-resistant CW-2 cells	1240:1285	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	7	41	from	uptake	1215:1220	arg1	cells					1281:1285	wild-type and oxaliplatin-resistant CW-2 cells	1240:1285	wild-type and oxaliplatin-resistant CW-2 cells	1240:1285	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	1	42	theme	N-glycosylated	203:216	arg1	transporter					169:179	Organic cation transporter	154:179	Organic cation transporter member 2 (OCT2)	154:195	Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
33376510	1	42	theme	N-glycosylated	203:216	arg1	transporter					218:228	an N-glycosylated transporter	200:228	an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs	200:311	Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
33376510	7	43	theme	β-1,6-GlcNAc	1086:1097	arg1	structures					1099:1108	β-1,6-GlcNAc structures	1086:1108	β-1,6-GlcNAc structures on OCT2	1086:1116	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	1	44	theme	antitumor	297:305	arg1	drugs					307:311	antitumor drugs	297:311	antitumor drugs	297:311	Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
33376510	5	45	theme	oxaliplatin	692:702	arg1	sensitivity					704:714	oxaliplatin sensitivity	692:714	oxaliplatin sensitivity involving the glycosylation of this drug transporter	692:767	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	5	45	theme	oxaliplatin	692:702	arg1	modification					787:798	specifically the modification	770:798	specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V)	770:890	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	7	46	theme	GnT-V	1035:1039	arg1	knockdown					1022:1030	the knockdown	1018:1030	the knockdown of GnT-V	1018:1039	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	2	47	theme	cancer	393:398	arg1	chemotherapy					366:377	the chemotherapy	362:377	the chemotherapy of colorectal cancer (CRC)	362:404	Oxaliplatin, a platinum-based drug, is used for the chemotherapy of colorectal cancer (CRC).
33376510	0	48	theme	colorectal	62:71	arg1	cells					80:84	human colorectal cancer cells	56:84	human colorectal cancer cells	56:84	Silencing GnT-V reduces oxaliplatin chemosensitivity in human colorectal cancer cells through N-glycan alteration of organic cation transporter member 2.
33376510	1	49	theme	drugs	307:311	arg1	transport					284:292	the transport	280:292	the transport of antitumor drugs	280:311	Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
33376510	6	50	theme	CW-2	993:996	arg1	cells					998:1002	CW-2 cells	993:1002	CW-2 cells	993:1002	The results revealed that the downregulation of GnT-V inhibited the oxaliplatin chemosensitivity of CW-2 cells.
33376510	6	51	theme	oxaliplatin	961:971	arg1	chemosensitivity					973:988	the oxaliplatin chemosensitivity	957:988	the oxaliplatin chemosensitivity of CW-2 cells	957:1002	The results revealed that the downregulation of GnT-V inhibited the oxaliplatin chemosensitivity of CW-2 cells.
33376510	0	52	theme	human	56:60	arg1	cells					80:84	human colorectal cancer cells	56:84	human colorectal cancer cells	56:84	Silencing GnT-V reduces oxaliplatin chemosensitivity in human colorectal cancer cells through N-glycan alteration of organic cation transporter member 2.
33376510	7	53	from	localization	1136:1147	arg1	cytomembrane					1164:1175	the cytomembrane	1160:1175	the cytomembrane	1160:1175	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	7	54	from	structures	1099:1108	arg1	OCT2					1113:1116	OCT2	1113:1116	OCT2	1113:1116	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	7	55	theme	oxaliplatin-resistant	1254:1274	arg1	cells					1281:1285	wild-type and oxaliplatin-resistant CW-2 cells	1240:1285	wild-type and oxaliplatin-resistant CW-2 cells	1240:1285	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	2	56	theme	platinum-based	329:342	arg1	drug					344:347	a platinum-based drug	327:347	a platinum-based drug	327:347	Oxaliplatin, a platinum-based drug, is used for the chemotherapy of colorectal cancer (CRC).
33376510	2	56	theme	platinum-based	329:342	arg1	Oxaliplatin					314:324	Oxaliplatin	314:324	Oxaliplatin	314:324	Oxaliplatin, a platinum-based drug, is used for the chemotherapy of colorectal cancer (CRC).
33376510	8	57	theme	transporter	1464:1474	arg1	OCT2					1476:1479	the drug transporter OCT2	1455:1479	the drug transporter OCT2	1455:1479	Overall, the study provides novel insights into the molecular mechanism by which GnT-V regulates the chemosensitivity to oxaliplatin, which involves the modulation of the drug transporter OCT2 by N-glycosylation in CRC cells.
33376510	6	58	theme	GnT-V	941:945	arg1	downregulation					923:936	the downregulation	919:936	the downregulation of GnT-V	919:945	The results revealed that the downregulation of GnT-V inhibited the oxaliplatin chemosensitivity of CW-2 cells.
33376510	5	59	theme	potential	653:661	arg1	strategy					669:676	a potential novel strategy	651:676	a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V)	651:890	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	5	60	theme	novel	663:667	arg1	strategy					669:676	a potential novel strategy	651:676	a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V)	651:890	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	8	61	theme	novel	1316:1320	arg1	insights					1322:1329	novel insights	1316:1329	novel insights into the molecular mechanism by which GnT-V regulates the chemosensitivity to oxaliplatin, which involves the modulation of the drug transporter OCT2 by N-glycosylation in CRC cells	1316:1511	Overall, the study provides novel insights into the molecular mechanism by which GnT-V regulates the chemosensitivity to oxaliplatin, which involves the modulation of the drug transporter OCT2 by N-glycosylation in CRC cells.
33376510	8	62	from	N-glycosylation	1484:1498	arg1	cells					1507:1511	CRC cells	1503:1511	CRC cells	1503:1511	Overall, the study provides novel insights into the molecular mechanism by which GnT-V regulates the chemosensitivity to oxaliplatin, which involves the modulation of the drug transporter OCT2 by N-glycosylation in CRC cells.
33376510	5	63	theme	N-acetylglucosaminyltransferase	850:880	arg1	GnT-V					885:889	GnT-V	885:889	GnT-V	885:889	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	5	63	theme	N-acetylglucosaminyltransferase	850:880	arg1	V					882:882	N-acetylglucosaminyltransferase V	850:882	N-acetylglucosaminyltransferase V (GnT-V)	850:890	The present study describes a potential novel strategy for enhancing oxaliplatin sensitivity involving the glycosylation of this drug transporter, specifically the modification of β-1,6-N-acetylglucosamine (GlcNAc) residues by N-acetylglucosaminyltransferase V (GnT-V).
33376510	8	64	theme	drug	1459:1462	arg1	OCT2					1476:1479	the drug transporter OCT2	1455:1479	the drug transporter OCT2	1455:1479	Overall, the study provides novel insights into the molecular mechanism by which GnT-V regulates the chemosensitivity to oxaliplatin, which involves the modulation of the drug transporter OCT2 by N-glycosylation in CRC cells.
33376510	1	65	theme	Organic	154:160	arg1	OCT2					191:194	OCT2	191:194	OCT2	191:194	Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
33376510	1	65	theme	Organic	154:160	arg1	transporter					169:179	Organic cation transporter	154:179	Organic cation transporter member 2 (OCT2)	154:195	Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
33376510	1	65	theme	Organic	154:160	arg1	transporter					218:228	an N-glycosylated transporter	200:228	an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs	200:311	Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
33376510	7	66	theme	wild-type	1240:1248	arg1	cells					1281:1285	wild-type and oxaliplatin-resistant CW-2 cells	1240:1285	wild-type and oxaliplatin-resistant CW-2 cells	1240:1285	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	7	67	from	reduction	1057:1065	arg1	presence					1074:1081	the presence	1070:1081	the presence of β-1,6-GlcNAc structures on OCT2	1070:1116	Furthermore, the knockdown of GnT-V caused a marked reduction in the presence of β-1,6-GlcNAc structures on OCT2 and decreased the localization of OCT2 in the cytomembrane, which were associated with a reduced uptake of oxaliplatin in wild-type and oxaliplatin-resistant CW-2 cells.
33376510	0	68	theme	cancer	73:78	arg1	cells					80:84	human colorectal cancer cells	56:84	human colorectal cancer cells	56:84	Silencing GnT-V reduces oxaliplatin chemosensitivity in human colorectal cancer cells through N-glycan alteration of organic cation transporter member 2.
33376510	1	69	theme	cation	162:167	arg1	OCT2					191:194	OCT2	191:194	OCT2	191:194	Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
33376510	1	69	theme	cation	162:167	arg1	transporter					169:179	Organic cation transporter	154:179	Organic cation transporter member 2 (OCT2)	154:195	Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
33376510	1	69	theme	cation	162:167	arg1	transporter					218:228	an N-glycosylated transporter	200:228	an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs	200:311	Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs.
31991208	4	0	dep	CNC	724:726	arg1	the					720:722	the	720:722	the	720:722	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	4	1	theme	stimulus-responsive	689:707	arg1	feature					709:715	the water stimulus-responsive feature	679:715	the water stimulus-responsive feature of the CNC and PEGDA	679:736	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	3	2	theme	PEGDA	514:518	arg1	films					531:535	highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films	429:535	highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films	429:535	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	1	3	theme	helical	257:263	arg1	structure					265:273	their unique helical structure	244:273	their unique helical structure	244:273	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	5	4	theme	crosslinking	873:884	arg1	degrees					886:892	different crosslinking degrees	863:892	different crosslinking degrees	863:892	In addition, it could produce different crosslinking degrees by coating the PEGMA solution or not, which could be applied to an anti-counterfeit label.
31991208	3	5	theme	composite	521:529	arg1	films					531:535	highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films	429:535	highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films	429:535	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	5	6	theme	different	863:871	arg1	degrees					886:892	different crosslinking degrees	863:892	different crosslinking degrees	863:892	In addition, it could produce different crosslinking degrees by coating the PEGMA solution or not, which could be applied to an anti-counterfeit label.
31991208	3	7	theme	co-assembling	560:572	arg1	CNC					574:576	co-assembling CNC	560:576	co-assembling CNC	560:576	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	2	8	theme	weak	330:333	arg1	properties					346:355	weak mechanical properties	330:355	weak mechanical properties	330:355	However, the general weak mechanical properties and poor water-resistance of CNC limit its utility.
31991208	4	9	theme	8/2	754:756	arg1	detector					807:814	a water-content detector	791:814	a water-content detector	791:814	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	4	9	theme	8/2	754:756	arg1	film					769:772	the CNC/PEGDA (8/2) composite film	739:772	the CNC/PEGDA (8/2) composite film	739:772	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	1	10	theme	excellent	279:287	arg1	properties					297:306	excellent optical properties	279:306	excellent optical properties	279:306	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	3	11	theme	diacrylate	503:512	arg1	films					531:535	highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films	429:535	highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films	429:535	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	3	12	theme	ethylene	486:493	arg1	CNC/Poly					477:484	chiral nematic CNC/Poly	462:484	highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films	429:535	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	3	12	theme	ethylene	486:493	arg1	glycol					495:500	ethylene glycol	486:500	ethylene glycol	486:500	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	3	13	theme	flexible	436:443	arg1	films					531:535	highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films	429:535	highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films	429:535	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	4	14	theme	photonic	817:824	arg1	detector					807:814	a water-content detector	791:814	a water-content detector	791:814	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	4	14	theme	photonic	817:824	arg1	paper					826:830	photonic paper	817:830	photonic paper	817:830	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	2	15	theme	mechanical	335:344	arg1	properties					346:355	weak mechanical properties	330:355	weak mechanical properties	330:355	However, the general weak mechanical properties and poor water-resistance of CNC limit its utility.
31991208	6	16	with	film	999:1002	arg1	stability					1019:1027	excellent stability	1009:1027	excellent stability of cycles	1009:1037	The composite film with excellent stability of cycles is expected to be a promising candidate in optical sensors, display, and security fields.
31991208	3	17	theme	chiral	462:467	arg1	CNC/Poly					477:484	chiral nematic CNC/Poly	462:484	highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films	429:535	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	3	17	theme	chiral	462:467	arg1	glycol					495:500	ethylene glycol	486:500	ethylene glycol	486:500	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	6	18	theme	security	1112:1119	arg1	fields					1121:1126	security fields	1112:1126	security fields	1112:1126	The composite film with excellent stability of cycles is expected to be a promising candidate in optical sensors, display, and security fields.
31991208	6	19	from	candidate	1069:1077	arg1	display					1099:1105	display	1099:1105	display	1099:1105	The composite film with excellent stability of cycles is expected to be a promising candidate in optical sensors, display, and security fields.
31991208	6	19	from	candidate	1069:1077	arg1	sensors					1090:1096	optical sensors	1082:1096	optical sensors	1082:1096	The composite film with excellent stability of cycles is expected to be a promising candidate in optical sensors, display, and security fields.
31991208	6	19	from	candidate	1069:1077	arg1	fields					1121:1126	security fields	1112:1126	security fields	1112:1126	The composite film with excellent stability of cycles is expected to be a promising candidate in optical sensors, display, and security fields.
31991208	1	20	theme	Chiral	106:111	arg1	CNC					144:146	CNC	144:146	CNC	144:146	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	1	20	theme	Chiral	106:111	arg1	nanocrystal					131:141	Chiral nematic cellulose nanocrystal	106:141	Chiral nematic cellulose nanocrystal (CNC) structural colored materials	106:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	2	21	dep	properties	346:355	arg1	the					318:320	the	318:320	the	318:320	However, the general weak mechanical properties and poor water-resistance of CNC limit its utility.
31991208	1	22	theme	extensive	195:203	arg1	research					205:212	extensive research	195:212	extensive research in recent years	195:228	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	0	23	theme	Multifunctional	0:14	arg1	cellulose					16:24	Multifunctional cellulose	0:24	Multifunctional cellulose	0:24	Multifunctional cellulose nanocrystal structural colored film with good flexibility and water-resistance.
31991208	1	24	theme	optical	289:295	arg1	properties					297:306	excellent optical properties	279:306	excellent optical properties	279:306	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	1	25	theme	nematic	113:119	arg1	CNC					144:146	CNC	144:146	CNC	144:146	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	1	25	theme	nematic	113:119	arg1	nanocrystal					131:141	Chiral nematic cellulose nanocrystal	106:141	Chiral nematic cellulose nanocrystal (CNC) structural colored materials	106:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	4	26	used	used	783:786	arg2	film					769:772	the CNC/PEGDA (8/2) composite film	739:772	the CNC/PEGDA (8/2) composite film	739:772	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	4	26	used	used	783:786	arg2	detector					807:814	a water-content detector	791:814	a water-content detector	791:814	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	1	27	theme	research	205:212	arg1	materials					168:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials	106:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials	106:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	1	27	theme	research	205:212	arg1	focus					186:190	the focus	182:190	the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties	182:306	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	0	28	theme	structural	38:47	arg1	film					57:60	structural colored film	38:60	structural colored film with good flexibility and water-resistance	38:103	Multifunctional cellulose nanocrystal structural colored film with good flexibility and water-resistance.
31991208	5	29	theme	PEGMA	909:913	arg1	solution					915:922	the PEGMA solution	905:922	the PEGMA solution	905:922	In addition, it could produce different crosslinking degrees by coating the PEGMA solution or not, which could be applied to an anti-counterfeit label.
31991208	1	30	theme	cellulose	121:129	arg1	CNC					144:146	CNC	144:146	CNC	144:146	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	1	30	theme	cellulose	121:129	arg1	nanocrystal					131:141	Chiral nematic cellulose nanocrystal	106:141	Chiral nematic cellulose nanocrystal (CNC) structural colored materials	106:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	4	31	theme	water-content	793:805	arg1	detector					807:814	a water-content detector	791:814	a water-content detector	791:814	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	4	31	theme	water-content	793:805	arg1	paper					826:830	photonic paper	817:830	photonic paper	817:830	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	4	31	theme	water-content	793:805	arg1	film					769:772	the CNC/PEGDA (8/2) composite film	739:772	the CNC/PEGDA (8/2) composite film	739:772	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	5	32	dep	anti-counterfeit	961:976	arg1	label					978:982	label	978:982	label	978:982	In addition, it could produce different crosslinking degrees by coating the PEGMA solution or not, which could be applied to an anti-counterfeit label.
31991208	2	33	theme	general	322:328	arg1	properties					346:355	weak mechanical properties	330:355	weak mechanical properties	330:355	However, the general weak mechanical properties and poor water-resistance of CNC limit its utility.
31991208	3	34	theme	crosslinking	650:661	arg1	network					663:669	a three-dimensional crosslinking network	630:669	a three-dimensional crosslinking network	630:669	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	1	35	theme	nanocrystal	131:141	arg1	materials					168:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials	106:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials	106:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	1	35	theme	nanocrystal	131:141	arg1	focus					186:190	the focus	182:190	the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties	182:306	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	1	36	theme	recent	217:222	arg1	years					224:228	recent years	217:228	recent years	217:228	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	6	37	theme	excellent	1009:1017	arg1	stability					1019:1027	excellent stability	1009:1027	excellent stability of cycles	1009:1037	The composite film with excellent stability of cycles is expected to be a promising candidate in optical sensors, display, and security fields.
31991208	3	38	dep	flexible	436:443	arg1	water-resistant					446:460	water-resistant	446:460	water-resistant	446:460	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	6	39	theme	cycles	1032:1037	arg1	stability					1019:1027	excellent stability	1009:1027	excellent stability of cycles	1009:1037	The composite film with excellent stability of cycles is expected to be a promising candidate in optical sensors, display, and security fields.
31991208	3	40	theme	nematic	469:475	arg1	CNC/Poly					477:484	chiral nematic CNC/Poly	462:484	highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films	429:535	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	3	40	theme	nematic	469:475	arg1	glycol					495:500	ethylene glycol	486:500	ethylene glycol	486:500	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	0	41	theme	colored	49:55	arg1	film					57:60	structural colored film	38:60	structural colored film with good flexibility and water-resistance	38:103	Multifunctional cellulose nanocrystal structural colored film with good flexibility and water-resistance.
31991208	1	42	from	years	224:228	arg1	materials					168:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials	106:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials	106:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	1	42	from	years	224:228	arg1	focus					186:190	the focus	182:190	the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties	182:306	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	3	43	theme	CNC/Poly	477:484	arg1	films					531:535	highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films	429:535	highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films	429:535	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	0	44	theme	good	67:70	arg1	flexibility					72:82	good flexibility	67:82	good flexibility	67:82	Multifunctional cellulose nanocrystal structural colored film with good flexibility and water-resistance.
31991208	3	45	theme	three-dimensional	632:648	arg1	network					663:669	a three-dimensional crosslinking network	630:669	a three-dimensional crosslinking network	630:669	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	3	46	theme	PEGDA	582:586	arg1	precursor					588:596	PEGDA precursor	582:596	PEGDA precursor	582:596	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	2	47	theme	poor	361:364	arg1	water-resistance					366:381	poor water-resistance	361:381	poor water-resistance	361:381	However, the general weak mechanical properties and poor water-resistance of CNC limit its utility.
31991208	6	48	theme	composite	989:997	arg1	candidate					1069:1077	a promising candidate	1057:1077	a promising candidate in optical sensors, display, and security fields	1057:1126	The composite film with excellent stability of cycles is expected to be a promising candidate in optical sensors, display, and security fields.
31991208	6	48	theme	composite	989:997	arg1	film					999:1002	The composite film	985:1002	The composite film with excellent stability of cycles	985:1037	The composite film with excellent stability of cycles is expected to be a promising candidate in optical sensors, display, and security fields.
31991208	4	49	theme	CNC	724:726	arg1	feature					709:715	the water stimulus-responsive feature	679:715	the water stimulus-responsive feature of the CNC and PEGDA	679:736	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	4	50	theme	water	683:687	arg1	feature					709:715	the water stimulus-responsive feature	679:715	the water stimulus-responsive feature of the CNC and PEGDA	679:736	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	4	51	theme	PEGDA	732:736	arg1	feature					709:715	the water stimulus-responsive feature	679:715	the water stimulus-responsive feature of the CNC and PEGDA	679:736	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	0	52	with	film	57:60	arg1	water-resistance					88:103	water-resistance	88:103	water-resistance	88:103	Multifunctional cellulose nanocrystal structural colored film with good flexibility and water-resistance.
31991208	0	52	with	film	57:60	arg1	flexibility					72:82	good flexibility	67:82	good flexibility	67:82	Multifunctional cellulose nanocrystal structural colored film with good flexibility and water-resistance.
31991208	4	53	theme	composite	759:767	arg1	detector					807:814	a water-content detector	791:814	a water-content detector	791:814	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	4	53	theme	composite	759:767	arg1	film					769:772	the CNC/PEGDA (8/2) composite film	739:772	the CNC/PEGDA (8/2) composite film	739:772	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	4	54	theme	CNC/PEGDA	743:751	arg1	detector					807:814	a water-content detector	791:814	a water-content detector	791:814	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	4	54	theme	CNC/PEGDA	743:751	arg1	film					769:772	the CNC/PEGDA (8/2) composite film	739:772	the CNC/PEGDA (8/2) composite film	739:772	Due to the water stimulus-responsive feature of the CNC and PEGDA, the CNC/PEGDA (8/2) composite film could be used as a water-content detector, photonic paper.
31991208	1	55	theme	structural	149:158	arg1	materials					168:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials	106:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials	106:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	1	55	theme	structural	149:158	arg1	focus					186:190	the focus	182:190	the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties	182:306	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	6	56	theme	optical	1082:1088	arg1	sensors					1090:1096	optical sensors	1082:1096	optical sensors	1082:1096	The composite film with excellent stability of cycles is expected to be a promising candidate in optical sensors, display, and security fields.
31991208	6	57	theme	promising	1059:1067	arg1	candidate					1069:1077	a promising candidate	1057:1077	a promising candidate in optical sensors, display, and security fields	1057:1126	The composite film with excellent stability of cycles is expected to be a promising candidate in optical sensors, display, and security fields.
31991208	6	57	theme	promising	1059:1067	arg1	film					999:1002	The composite film	985:1002	The composite film with excellent stability of cycles	985:1037	The composite film with excellent stability of cycles is expected to be a promising candidate in optical sensors, display, and security fields.
31991208	3	58	theme	UV	607:608	arg1	curing					610:615	UV curing	607:615	UV curing	607:615	Here, we fabricated highly flexible, water-resistant chiral nematic CNC/Poly(ethylene glycol) diacrylate(PEGDA) composite films, which was realized by co-assembling CNC and PEGDA precursor then via UV curing to construct a three-dimensional crosslinking network.
31991208	1	59	from	research	205:212	arg1	years					224:228	recent years	217:228	recent years	217:228	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	1	60	theme	colored	160:166	arg1	materials					168:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials	106:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials	106:176	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	1	60	theme	colored	160:166	arg1	focus					186:190	the focus	182:190	the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties	182:306	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	1	61	from	focus	186:190	arg1	years					224:228	recent years	217:228	recent years	217:228	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
31991208	2	62	theme	CNC	386:388	arg1	properties					346:355	weak mechanical properties	330:355	weak mechanical properties	330:355	However, the general weak mechanical properties and poor water-resistance of CNC limit its utility.
31991208	2	62	theme	CNC	386:388	arg1	water-resistance					366:381	poor water-resistance	361:381	poor water-resistance	361:381	However, the general weak mechanical properties and poor water-resistance of CNC limit its utility.
31991208	1	63	theme	unique	250:255	arg1	structure					265:273	their unique helical structure	244:273	their unique helical structure	244:273	Chiral nematic cellulose nanocrystal (CNC) structural colored materials are the focus of extensive research in recent years on account of their unique helical structure and excellent optical properties.
34863969	0	0	theme	knee	105:108	arg1	scaffold					119:126	human knee meniscal scaffold	99:126	human knee meniscal scaffold	99:126	Tricomposite gelatin-carboxymethylcellulose-alginate bioink for direct and indirect 3D printing of human knee meniscal scaffold.
34863969	2	1	theme	customizable	526:537	arg1	scaffolds					539:547	customizable scaffolds	526:547	customizable scaffolds for cartilage tissue engineering applications	526:593	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
34863969	7	2	from	proliferation	1427:1439	arg1	properties					1470:1479	biomechanical properties	1456:1479	biomechanical properties	1456:1479	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	7	3	theme	cartilage	1574:1582	arg1	engineering					1591:1601	cartilage tissue engineering	1574:1601	cartilage tissue engineering	1574:1601	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	0	4	theme	human	99:103	arg1	scaffold					119:126	human knee meniscal scaffold	99:126	human knee meniscal scaffold	99:126	Tricomposite gelatin-carboxymethylcellulose-alginate bioink for direct and indirect 3D printing of human knee meniscal scaffold.
34863969	6	5	theme	estimation	1353:1362	arg1	assays					1364:1369	MTT, live/dead and collagen estimation assays	1325:1369	assays	1364:1369	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	6	6	from	scaffold	1294:1301	arg1	secretion					1253:1261	The cellular proliferation, apatite formation, and extracellular matrix secretion	1181:1261	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold	1181:1301	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	2	7	theme	cartilage	553:561	arg1	applications					582:593	cartilage tissue engineering applications	553:593	cartilage tissue engineering applications	553:593	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
34863969	0	8	theme	scaffold	119:126	arg1	printing					87:94	direct and indirect 3D printing	64:94	direct and indirect 3D printing of human knee meniscal scaffold	64:126	Tricomposite gelatin-carboxymethylcellulose-alginate bioink for direct and indirect 3D printing of human knee meniscal scaffold.
34863969	6	9	theme	meniscal	1285:1292	arg1	scaffold					1294:1301	negative printed meniscal scaffold	1268:1301	negative printed meniscal scaffold	1268:1301	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	3	10	theme	customized	598:607	arg1	scaffold					631:638	A customized hierarchical meniscal scaffold	596:638	A customized hierarchical meniscal scaffold	596:638	A customized hierarchical meniscal scaffold was designed using solid works software and developed using a negative mould made of polylactic acid (PLA) filament and by a direct 3D printing process.
34863969	5	11	theme	hydrogel	1021:1028	arg1	bioink					1030:1035	The optimized composite hydrogel bioink	997:1035	The optimized composite hydrogel bioink	997:1035	The optimized composite hydrogel bioink was extruded into the negative mould with and without live cells, cross-linked and the replica of meniscus structure was retrieved aseptically.
34863969	1	12	theme	damaged	322:328	arg1	tissue					330:335	damaged tissue	322:335	damaged tissue	322:335	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	0	13	theme	meniscal	110:117	arg1	scaffold					119:126	human knee meniscal scaffold	99:126	human knee meniscal scaffold	99:126	Tricomposite gelatin-carboxymethylcellulose-alginate bioink for direct and indirect 3D printing of human knee meniscal scaffold.
34863969	3	14	theme	3D	772:773	arg1	process					784:790	a direct 3D printing process	763:790	a direct 3D printing process	763:790	A customized hierarchical meniscal scaffold was designed using solid works software and developed using a negative mould made of polylactic acid (PLA) filament and by a direct 3D printing process.
34863969	4	15	theme	tripolymeric	805:816	arg1	bioink					818:823	A composite tripolymeric bioink	793:823	A composite tripolymeric bioink made of gelatin, carboxymethyl cellulose (CMC) and alginate	793:883	A composite tripolymeric bioink made of gelatin, carboxymethyl cellulose (CMC) and alginate was optimized and characterized for its printability, structural, bio-mechanical and bio-functional properties.
34863969	3	16	theme	hierarchical	609:620	arg1	scaffold					631:638	A customized hierarchical meniscal scaffold	596:638	A customized hierarchical meniscal scaffold	596:638	A customized hierarchical meniscal scaffold was designed using solid works software and developed using a negative mould made of polylactic acid (PLA) filament and by a direct 3D printing process.
34863969	2	17	theme	tissue	563:568	arg1	applications					582:593	cartilage tissue engineering applications	553:593	cartilage tissue engineering applications	553:593	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
34863969	3	18	theme	printing	775:782	arg1	process					784:790	a direct 3D printing process	763:790	a direct 3D printing process	763:790	A customized hierarchical meniscal scaffold was designed using solid works software and developed using a negative mould made of polylactic acid (PLA) filament and by a direct 3D printing process.
34863969	6	19	theme	collagen	1344:1351	arg1	assays					1364:1369	MTT, live/dead and collagen estimation assays	1325:1369	assays	1364:1369	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	7	20	theme	collagen	1398:1405	arg1	secretion					1407:1415	collagen secretion	1398:1415	collagen secretion	1398:1415	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	6	21	theme	matrix	1246:1251	arg1	secretion					1253:1261	The cellular proliferation, apatite formation, and extracellular matrix secretion	1181:1261	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold	1181:1301	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	7	22	from	changes	1445:1451	arg1	properties					1470:1479	biomechanical properties	1456:1479	biomechanical properties	1456:1479	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	7	23	theme	cellular	1418:1425	arg1	proliferation					1427:1439	cellular proliferation	1418:1439	cellular proliferation	1418:1439	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	2	24	theme	direct	494:499	arg1	printing					514:521	both direct and indirect printing	489:521	both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications	489:593	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
34863969	6	25	theme	formation	1217:1225	arg1	secretion					1253:1261	The cellular proliferation, apatite formation, and extracellular matrix secretion	1181:1261	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold	1181:1301	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	6	26	theme	extracellular	1232:1244	arg1	matrix					1246:1251	extracellular matrix	1232:1251	extracellular matrix	1232:1251	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	1	27	theme	customizable	195:206	arg1	tissue					225:230	customizable patient-specific tissue	195:230	customizable patient-specific tissue	195:230	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	0	28	theme	gelatin-carboxymethylcellulose-alginate	13:51	arg1	bioink					53:58	gelatin-carboxymethylcellulose-alginate bioink	13:58	gelatin-carboxymethylcellulose-alginate bioink for direct and indirect 3D printing of human knee meniscal scaffold	13:126	Tricomposite gelatin-carboxymethylcellulose-alginate bioink for direct and indirect 3D printing of human knee meniscal scaffold.
34863969	3	29	theme	direct	765:770	arg1	process					784:790	a direct 3D printing process	763:790	a direct 3D printing process	763:790	A customized hierarchical meniscal scaffold was designed using solid works software and developed using a negative mould made of polylactic acid (PLA) filament and by a direct 3D printing process.
34863969	6	30	theme	live/dead	1330:1338	arg1	assays					1364:1369	MTT, live/dead and collagen estimation assays	1325:1369	assays	1364:1369	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	5	31	theme	composite	1011:1019	arg1	bioink					1030:1035	The optimized composite hydrogel bioink	997:1035	The optimized composite hydrogel bioink	997:1035	The optimized composite hydrogel bioink was extruded into the negative mould with and without live cells, cross-linked and the replica of meniscus structure was retrieved aseptically.
34863969	7	32	theme	tissue	1584:1589	arg1	engineering					1591:1601	cartilage tissue engineering	1574:1601	cartilage tissue engineering	1574:1601	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	1	33	theme	patient-specific	208:223	arg1	tissue					225:230	customizable patient-specific tissue	195:230	customizable patient-specific tissue	195:230	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	7	34	located	observed	1485:1492	arg1	scaffolds					1504:1512	the 3D scaffolds	1497:1512	the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering	1497:1601	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	7	34	located	observed	1485:1492	arg2	increase					1386:1393	A significant increase	1372:1393	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties	1372:1479	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	3	35	theme	acid	736:739	arg1	filament					747:754	polylactic acid (PLA) filament	725:754	polylactic acid (PLA) filament	725:754	A customized hierarchical meniscal scaffold was designed using solid works software and developed using a negative mould made of polylactic acid (PLA) filament and by a direct 3D printing process.
34863969	5	36	theme	optimized	1001:1009	arg1	bioink					1030:1035	The optimized composite hydrogel bioink	997:1035	The optimized composite hydrogel bioink	997:1035	The optimized composite hydrogel bioink was extruded into the negative mould with and without live cells, cross-linked and the replica of meniscus structure was retrieved aseptically.
34863969	7	37	theme	biomechanical	1456:1468	arg1	properties					1470:1479	biomechanical properties	1456:1479	biomechanical properties	1456:1479	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	1	38	theme	tissue	225:230	arg1	production					181:190	the production	177:190	the production of customizable patient-specific tissue	177:230	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	2	39	theme	suitable	476:483	arg1	bioink					468:473	composite, bioactive and biocompatible tripolymeric hydrogel bioink	407:473	composite, bioactive and biocompatible tripolymeric hydrogel bioink	407:473	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
34863969	4	40	theme	bio-functional	970:983	arg1	properties					985:994	structural, bio-mechanical and bio-functional properties	939:994	structural, bio-mechanical and bio-functional properties	939:994	A composite tripolymeric bioink made of gelatin, carboxymethyl cellulose (CMC) and alginate was optimized and characterized for its printability, structural, bio-mechanical and bio-functional properties.
34863969	4	40	theme	bio-functional	970:983	arg1	printability					925:936	its printability	921:936	its printability	921:936	A composite tripolymeric bioink made of gelatin, carboxymethyl cellulose (CMC) and alginate was optimized and characterized for its printability, structural, bio-mechanical and bio-functional properties.
34863969	3	41	theme	meniscal	622:629	arg1	scaffold					631:638	A customized hierarchical meniscal scaffold	596:638	A customized hierarchical meniscal scaffold	596:638	A customized hierarchical meniscal scaffold was designed using solid works software and developed using a negative mould made of polylactic acid (PLA) filament and by a direct 3D printing process.
34863969	6	42	theme	MTT	1325:1327	arg1	assays					1364:1369	MTT, live/dead and collagen estimation assays	1325:1369	assays	1364:1369	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	2	43	theme	bioink	468:473	arg1	optimization					391:402	the optimization	387:402	the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications	387:593	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
34863969	7	44	theme	MG63-osteosarcoma	1519:1535	arg1	cells					1537:1541	MG63-osteosarcoma cells	1519:1541	MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering	1519:1601	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	1	45	dep	ease	172:175	arg1	restoring					300:308	restoring	300:308	restoring function in damaged tissue	300:335	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	1	45	dep	ease	172:175	arg1	engineering					232:242	engineering	232:242	engineering constructs having required biomechanical properties	232:294	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	2	46	theme	hydrogel	459:466	arg1	bioink					468:473	composite, bioactive and biocompatible tripolymeric hydrogel bioink	407:473	composite, bioactive and biocompatible tripolymeric hydrogel bioink	407:473	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
34863969	6	47	theme	proliferation	1194:1206	arg1	secretion					1253:1261	The cellular proliferation, apatite formation, and extracellular matrix secretion	1181:1261	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold	1181:1301	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	1	48	from	function	310:317	arg1	tissue					330:335	damaged tissue	322:335	damaged tissue	322:335	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	7	49	theme	significant	1374:1384	arg1	increase					1386:1393	A significant increase	1372:1393	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties	1372:1479	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	3	50	theme	works	665:669	arg1	software					671:678	solid works software	659:678	solid works software	659:678	A customized hierarchical meniscal scaffold was designed using solid works software and developed using a negative mould made of polylactic acid (PLA) filament and by a direct 3D printing process.
34863969	2	51	theme	composite	407:415	arg1	bioink					468:473	composite, bioactive and biocompatible tripolymeric hydrogel bioink	407:473	composite, bioactive and biocompatible tripolymeric hydrogel bioink	407:473	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
34863969	2	52	theme	tripolymeric	446:457	arg1	bioink					468:473	composite, bioactive and biocompatible tripolymeric hydrogel bioink	407:473	composite, bioactive and biocompatible tripolymeric hydrogel bioink	407:473	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
34863969	0	53	theme	direct	64:69	arg1	printing					87:94	direct and indirect 3D printing	64:94	direct and indirect 3D printing of human knee meniscal scaffold	64:126	Tricomposite gelatin-carboxymethylcellulose-alginate bioink for direct and indirect 3D printing of human knee meniscal scaffold.
34863969	2	54	theme	indirect	505:512	arg1	printing					514:521	both direct and indirect printing	489:521	both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications	489:593	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
34863969	3	55	theme	negative	702:709	arg1	mould					711:715	a negative mould	700:715	a negative mould made of polylactic acid (PLA) filament and by a direct 3D printing process	700:790	A customized hierarchical meniscal scaffold was designed using solid works software and developed using a negative mould made of polylactic acid (PLA) filament and by a direct 3D printing process.
34863969	7	56	with	scaffolds	1504:1512	arg1	cells					1537:1541	MG63-osteosarcoma cells	1519:1541	MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering	1519:1601	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	1	57	theme	required	262:269	arg1	properties					285:294	required biomechanical properties	262:294	required biomechanical properties	262:294	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	0	58	theme	3D	84:85	arg1	printing					87:94	direct and indirect 3D printing	64:94	direct and indirect 3D printing of human knee meniscal scaffold	64:126	Tricomposite gelatin-carboxymethylcellulose-alginate bioink for direct and indirect 3D printing of human knee meniscal scaffold.
34863969	1	59	theme	hour	356:359	arg1	need					344:347	the need	340:347	the need of the hour	340:359	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	1	59	theme	hour	356:359	arg1	development					133:143	The development	129:143	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue	129:335	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	4	60	theme	structural	939:948	arg1	properties					985:994	structural, bio-mechanical and bio-functional properties	939:994	structural, bio-mechanical and bio-functional properties	939:994	A composite tripolymeric bioink made of gelatin, carboxymethyl cellulose (CMC) and alginate was optimized and characterized for its printability, structural, bio-mechanical and bio-functional properties.
34863969	4	60	theme	structural	939:948	arg1	printability					925:936	its printability	921:936	its printability	921:936	A composite tripolymeric bioink made of gelatin, carboxymethyl cellulose (CMC) and alginate was optimized and characterized for its printability, structural, bio-mechanical and bio-functional properties.
34863969	5	61	theme	structure	1144:1152	arg1	replica					1124:1130	the replica	1120:1130	the replica of meniscus structure	1120:1152	The optimized composite hydrogel bioink was extruded into the negative mould with and without live cells, cross-linked and the replica of meniscus structure was retrieved aseptically.
34863969	5	62	theme	live	1091:1094	arg1	cells					1096:1100	live cells	1091:1100	live cells	1091:1100	The optimized composite hydrogel bioink was extruded into the negative mould with and without live cells, cross-linked and the replica of meniscus structure was retrieved aseptically.
34863969	7	63	from	increase	1386:1393	arg1	changes					1445:1451	changes	1445:1451	changes in biomechanical properties	1445:1479	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	7	63	from	increase	1386:1393	arg1	secretion					1407:1415	collagen secretion	1398:1415	collagen secretion	1398:1415	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	7	63	from	increase	1386:1393	arg1	proliferation					1427:1439	cellular proliferation	1418:1439	cellular proliferation	1418:1439	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	0	64	theme	indirect	75:82	arg1	printing					87:94	direct and indirect 3D printing	64:94	direct and indirect 3D printing of human knee meniscal scaffold	64:126	Tricomposite gelatin-carboxymethylcellulose-alginate bioink for direct and indirect 3D printing of human knee meniscal scaffold.
34863969	3	65	theme	solid	659:663	arg1	software					671:678	solid works software	659:678	solid works software	659:678	A customized hierarchical meniscal scaffold was designed using solid works software and developed using a negative mould made of polylactic acid (PLA) filament and by a direct 3D printing process.
34863969	5	66	theme	meniscus	1135:1142	arg1	structure					1144:1152	meniscus structure	1135:1152	meniscus structure	1135:1152	The optimized composite hydrogel bioink was extruded into the negative mould with and without live cells, cross-linked and the replica of meniscus structure was retrieved aseptically.
34863969	6	67	theme	negative	1268:1275	arg1	scaffold					1294:1301	negative printed meniscal scaffold	1268:1301	negative printed meniscal scaffold	1268:1301	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	4	68	theme	bio-mechanical	951:964	arg1	properties					985:994	structural, bio-mechanical and bio-functional properties	939:994	structural, bio-mechanical and bio-functional properties	939:994	A composite tripolymeric bioink made of gelatin, carboxymethyl cellulose (CMC) and alginate was optimized and characterized for its printability, structural, bio-mechanical and bio-functional properties.
34863969	4	68	theme	bio-mechanical	951:964	arg1	printability					925:936	its printability	921:936	its printability	921:936	A composite tripolymeric bioink made of gelatin, carboxymethyl cellulose (CMC) and alginate was optimized and characterized for its printability, structural, bio-mechanical and bio-functional properties.
34863969	1	69	contain	having	255:260	arg1	constructs					244:253	constructs	244:253	constructs having required biomechanical properties	244:294	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	1	69	contain	having	255:260	arg2	properties					285:294	required biomechanical properties	262:294	required biomechanical properties	262:294	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	1	70	theme	technologies	148:159	arg1	need					344:347	the need	340:347	the need of the hour	340:359	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	1	70	theme	technologies	148:159	arg1	development					133:143	The development	129:143	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue	129:335	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	4	71	theme	composite	795:803	arg1	bioink					818:823	A composite tripolymeric bioink	793:823	A composite tripolymeric bioink made of gelatin, carboxymethyl cellulose (CMC) and alginate	793:883	A composite tripolymeric bioink made of gelatin, carboxymethyl cellulose (CMC) and alginate was optimized and characterized for its printability, structural, bio-mechanical and bio-functional properties.
34863969	1	72	theme	biomechanical	271:283	arg1	properties					285:294	required biomechanical properties	262:294	required biomechanical properties	262:294	The development of technologies that could ease the production of customizable patient-specific tissue engineering constructs having required biomechanical properties and restoring function in damaged tissue is the need of the hour.
34863969	3	73	theme	polylactic	725:734	arg1	acid					736:739	polylactic acid	725:739	polylactic acid (PLA) filament	725:754	A customized hierarchical meniscal scaffold was designed using solid works software and developed using a negative mould made of polylactic acid (PLA) filament and by a direct 3D printing process.
34863969	3	73	theme	polylactic	725:734	arg1	PLA					742:744	PLA	742:744	PLA	742:744	A customized hierarchical meniscal scaffold was designed using solid works software and developed using a negative mould made of polylactic acid (PLA) filament and by a direct 3D printing process.
34863969	5	74	theme	negative	1059:1066	arg1	mould					1068:1072	the negative mould	1055:1072	the negative mould	1055:1072	The optimized composite hydrogel bioink was extruded into the negative mould with and without live cells, cross-linked and the replica of meniscus structure was retrieved aseptically.
34863969	7	75	from	secretion	1407:1415	arg1	properties					1470:1479	biomechanical properties	1456:1479	biomechanical properties	1456:1479	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	6	76	theme	cellular	1185:1192	arg1	proliferation					1194:1206	cellular proliferation	1185:1206	cellular proliferation	1185:1206	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	2	77	theme	biocompatible	432:444	arg1	bioink					468:473	composite, bioactive and biocompatible tripolymeric hydrogel bioink	407:473	composite, bioactive and biocompatible tripolymeric hydrogel bioink	407:473	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
34863969	6	78	theme	printed	1277:1283	arg1	scaffold					1294:1301	negative printed meniscal scaffold	1268:1301	negative printed meniscal scaffold	1268:1301	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	2	79	theme	bioactive	418:426	arg1	bioink					468:473	composite, bioactive and biocompatible tripolymeric hydrogel bioink	407:473	composite, bioactive and biocompatible tripolymeric hydrogel bioink	407:473	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
34863969	2	80	theme	scaffolds	539:547	arg1	printing					514:521	both direct and indirect printing	489:521	both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications	489:593	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
34863969	6	81	theme	apatite	1209:1215	arg1	formation					1217:1225	apatite formation	1209:1225	apatite formation	1209:1225	The cellular proliferation, apatite formation, and extracellular matrix secretion from negative printed meniscal scaffold were determined using MTT, live/dead and collagen estimation assays.
34863969	4	82	theme	carboxymethyl	842:854	arg1	CMC					867:869	CMC	867:869	CMC	867:869	A composite tripolymeric bioink made of gelatin, carboxymethyl cellulose (CMC) and alginate was optimized and characterized for its printability, structural, bio-mechanical and bio-functional properties.
34863969	4	82	theme	carboxymethyl	842:854	arg1	cellulose					856:864	carboxymethyl cellulose	842:864	carboxymethyl cellulose (CMC)	842:870	A composite tripolymeric bioink made of gelatin, carboxymethyl cellulose (CMC) and alginate was optimized and characterized for its printability, structural, bio-mechanical and bio-functional properties.
34863969	7	83	theme	3D	1501:1502	arg1	scaffolds					1504:1512	the 3D scaffolds	1497:1512	the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering	1497:1601	A significant increase in collagen secretion, cellular proliferation and changes in biomechanical properties was observed in the 3D scaffolds with MG63-osteosarcoma cells indicating its suitability for cartilage tissue engineering.
34863969	2	84	theme	engineering	570:580	arg1	applications					582:593	cartilage tissue engineering applications	553:593	cartilage tissue engineering applications	553:593	In this study, we report the optimization of composite, bioactive and biocompatible tripolymeric hydrogel bioink, suitable for both direct and indirect printing of customizable scaffolds for cartilage tissue engineering applications.
33971478	10	0	theme	mechanical	1441:1450	arg1	properties					1452:1461	the mechanical properties	1437:1461	the mechanical properties	1437:1461	The internal microstructure of the glume is also porous and spongy, but the mechanical properties are mainly manifested in its macrostructure.
33971478	9	1	dep	structure	1311:1319	arg1	composed					1321:1328	composed	1321:1328	composed of cellulose	1321:1341	The woody ring is the primary source of mechanical strength, whose microstructure is a hollow tubular structure composed of cellulose and bonded by lignin.
33971478	9	1	dep	structure	1311:1319	arg1	bonded					1347:1352	bonded	1347:1352	bonded by lignin	1347:1362	The woody ring is the primary source of mechanical strength, whose microstructure is a hollow tubular structure composed of cellulose and bonded by lignin.
33971478	8	2	theme	good	1163:1166	arg1	properties					1178:1187	good buffering properties	1163:1187	good buffering properties under impact loads	1163:1206	It is also a progressively hardening material with good buffering properties under impact loads.
33971478	11	3	theme	subsequent	1566:1575	arg1	processing					1577:1586	subsequent processing	1566:1586	subsequent processing	1566:1586	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	7	4	theme	sponge-like	1024:1034	arg1	tissue					1036:1041	a porous sponge-like tissue	1015:1041	a porous sponge-like tissue that has a greater bearing capacity while maintaining a low density	1015:1109	The pith is a porous sponge-like tissue that has a greater bearing capacity while maintaining a low density.
33971478	7	4	theme	sponge-like	1024:1034	arg1	pith					1007:1010	The pith	1003:1010	The pith	1003:1010	The pith is a porous sponge-like tissue that has a greater bearing capacity while maintaining a low density.
33971478	2	5	theme	corn	264:267	arg1	cob					269:271	corn cob	264:271	corn cob	264:271	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	1	6	theme	special	149:155	arg1	structure					165:173	a special layered structure	147:173	a special layered structure	147:173	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	6	theme	special	149:155	arg1	properties					132:141	excellent mechanical properties	111:141	excellent mechanical properties	111:141	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	6	theme	special	149:155	arg1	resource					88:95	a natural biomass resource	70:95	a natural biomass resource	70:95	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	6	7	theme	corn	840:843	arg1	cob					845:847	a corn cob	838:847	a corn cob	838:847	The results show that a corn cob is structurally divided into the pith, woody ring, and glume, mainly composed of cellulose, hemicellulose, and lignin in fiber composition, respectively.
33971478	2	8	theme	3D	295:296	arg1	microscope					298:307	the ultra-deep field 3D microscope	274:307	the ultra-deep field 3D microscope	274:307	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	8	9	theme	impact	1195:1200	arg1	loads					1202:1206	impact loads	1195:1206	impact loads	1195:1206	It is also a progressively hardening material with good buffering properties under impact loads.
33971478	11	10	theme	bionic	1686:1691	arg1	structure					1643:1651	the unique structure	1632:1651	the unique structure of corn cob	1632:1663	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	11	10	theme	bionic	1686:1691	arg1	prototype					1693:1701	an excellent bionic prototype	1673:1701	an excellent bionic prototype for lightweight design	1673:1724	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	2	11	theme	ultra-deep	278:287	arg1	microscope					298:307	the ultra-deep field 3D microscope	274:307	the ultra-deep field 3D microscope	274:307	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	4	12	theme	compression	628:638	arg1	tests					685:689	Axial compression, radial compression, and three-point bending tests	622:689	Axial compression, radial compression, and three-point bending tests	622:689	Axial compression, radial compression, and three-point bending tests were performed on corn cob using a universal testing machine.
33971478	3	13	theme	fiber	574:578	arg1	composition					580:590	fiber composition	574:590	fiber composition	574:590	The Fourier transform infrared spectrometer was used to analyze the fiber composition, revealing the contribution of fiber composition to the mechanical properties.
33971478	6	14	dep	ring	894:897	arg1	woody					888:892	the pith, woody ring	878:897	woody	888:892	The results show that a corn cob is structurally divided into the pith, woody ring, and glume, mainly composed of cellulose, hemicellulose, and lignin in fiber composition, respectively.
33971478	1	15	theme	corn	98:101	arg1	cob					103:105	corn cob	98:105	corn cob	98:105	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	4	16	theme	corn	709:712	arg1	cob					714:716	corn cob	709:716	corn cob using a universal testing machine	709:750	Axial compression, radial compression, and three-point bending tests were performed on corn cob using a universal testing machine.
33971478	11	17	theme	corn	1656:1659	arg1	cob					1661:1663	corn cob	1656:1663	corn cob	1656:1663	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	3	18	theme	mechanical	599:608	arg1	properties					610:619	the mechanical properties	595:619	the mechanical properties	595:619	The Fourier transform infrared spectrometer was used to analyze the fiber composition, revealing the contribution of fiber composition to the mechanical properties.
33971478	4	19	theme	three-point	665:675	arg1	bending					677:683	three-point bending	665:683	three-point bending	665:683	Axial compression, radial compression, and three-point bending tests were performed on corn cob using a universal testing machine.
33971478	0	20	theme	corn	57:60	arg1	cob					62:64	corn cob	57:64	corn cob	57:64	The effect of microstructure on mechanical properties of corn cob.
33971478	1	21	theme	mechanical	121:130	arg1	structure					165:173	a special layered structure	147:173	a special layered structure	147:173	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	21	theme	mechanical	121:130	arg1	properties					132:141	excellent mechanical properties	111:141	excellent mechanical properties	111:141	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	21	theme	mechanical	121:130	arg1	resource					88:95	a natural biomass resource	70:95	a natural biomass resource	70:95	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	10	22	theme	internal	1369:1376	arg1	porous					1414:1419	porous	1414:1419	porous	1414:1419	The internal microstructure of the glume is also porous and spongy, but the mechanical properties are mainly manifested in its macrostructure.
33971478	10	22	theme	internal	1369:1376	arg1	microstructure					1378:1391	The internal microstructure	1365:1391	The internal microstructure of the glume	1365:1404	The internal microstructure of the glume is also porous and spongy, but the mechanical properties are mainly manifested in its macrostructure.
33971478	6	23	from	lignin	960:965	arg1	composition					976:986	fiber composition	970:986	fiber composition	970:986	The results show that a corn cob is structurally divided into the pith, woody ring, and glume, mainly composed of cellulose, hemicellulose, and lignin in fiber composition, respectively.
33971478	7	24	contain	has	1048:1050	arg1	pith					1007:1010	The pith	1003:1010	The pith	1003:1010	The pith is a porous sponge-like tissue that has a greater bearing capacity while maintaining a low density.
33971478	7	24	contain	has	1048:1050	arg1	tissue					1036:1041	a porous sponge-like tissue	1015:1041	a porous sponge-like tissue that has a greater bearing capacity while maintaining a low density	1015:1109	The pith is a porous sponge-like tissue that has a greater bearing capacity while maintaining a low density.
33971478	7	24	contain	has	1048:1050	arg2	capacity					1070:1077	a greater bearing capacity	1052:1077	a greater bearing capacity	1052:1077	The pith is a porous sponge-like tissue that has a greater bearing capacity while maintaining a low density.
33971478	2	25	theme	scanning	374:381	arg1	microscopy					392:401	the scanning electron microscopy	370:401	the scanning electron microscopy (SEM)	370:407	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	2	25	theme	scanning	374:381	arg1	SEM					404:406	SEM	404:406	SEM	404:406	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	3	26	dep	Fourier	461:467	arg1	transform					469:477	transform	469:477	transform infrared spectrometer	469:499	The Fourier transform infrared spectrometer was used to analyze the fiber composition, revealing the contribution of fiber composition to the mechanical properties.
33971478	2	27	used	used	313:316	arg2	microscope					298:307	the ultra-deep field 3D microscope	274:307	the ultra-deep field 3D microscope	274:307	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	9	28	theme	mechanical	1249:1258	arg1	strength					1260:1267	mechanical strength	1249:1267	mechanical strength	1249:1267	The woody ring is the primary source of mechanical strength, whose microstructure is a hollow tubular structure composed of cellulose and bonded by lignin.
33971478	1	29	theme	natural	72:78	arg1	structure					165:173	a special layered structure	147:173	a special layered structure	147:173	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	29	theme	natural	72:78	arg1	properties					132:141	excellent mechanical properties	111:141	excellent mechanical properties	111:141	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	29	theme	natural	72:78	arg1	resource					88:95	a natural biomass resource	70:95	a natural biomass resource	70:95	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	4	30	theme	universal	726:734	arg1	machine					744:750	a universal testing machine	724:750	a universal testing machine	724:750	Axial compression, radial compression, and three-point bending tests were performed on corn cob using a universal testing machine.
33971478	2	31	theme	corn	447:450	arg1	cob					452:454	the corn cob	443:454	the corn cob	443:454	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	11	32	theme	cob	1623:1625	arg1	processing					1577:1586	subsequent processing	1566:1586	subsequent processing	1566:1586	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	11	32	theme	cob	1623:1625	arg1	application					1603:1613	industrial application	1592:1613	industrial application	1592:1613	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	4	33	theme	radial	641:646	arg1	compression					648:658	radial compression	641:658	radial compression	641:658	Axial compression, radial compression, and three-point bending tests were performed on corn cob using a universal testing machine.
33971478	7	34	theme	bearing	1062:1068	arg1	capacity					1070:1077	a greater bearing capacity	1052:1077	a greater bearing capacity	1052:1077	The pith is a porous sponge-like tissue that has a greater bearing capacity while maintaining a low density.
33971478	5	35	used	used	793:796	arg2	machine					781:787	an impact testing machine	763:787	an impact testing machine	763:787	Moreover, an impact testing machine was used for impact tests.
33971478	11	36	theme	unique	1636:1641	arg1	structure					1643:1651	the unique structure	1632:1651	the unique structure of corn cob	1632:1663	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	11	36	theme	unique	1636:1641	arg1	prototype					1693:1701	an excellent bionic prototype	1673:1701	an excellent bionic prototype for lightweight design	1673:1724	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	9	37	theme	tubular	1303:1309	arg1	structure					1311:1319	a hollow tubular structure	1294:1319	a hollow tubular structure composed of cellulose and bonded by lignin	1294:1362	The woody ring is the primary source of mechanical strength, whose microstructure is a hollow tubular structure composed of cellulose and bonded by lignin.
33971478	9	37	theme	tubular	1303:1309	arg1	microstructure					1276:1289	microstructure	1276:1289	microstructure	1276:1289	The woody ring is the primary source of mechanical strength, whose microstructure is a hollow tubular structure composed of cellulose and bonded by lignin.
33971478	2	38	dep	properties	231:240	arg1	the					216:218	the	216:218	the	216:218	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	5	39	theme	impact	766:771	arg1	machine					781:787	an impact testing machine	763:787	an impact testing machine	763:787	Moreover, an impact testing machine was used for impact tests.
33971478	6	40	theme	pith	882:885	arg1	ring					894:897	the pith, woody ring	878:897	ring	894:897	The results show that a corn cob is structurally divided into the pith, woody ring, and glume, mainly composed of cellulose, hemicellulose, and lignin in fiber composition, respectively.
33971478	11	41	theme	study	1528:1532	arg1	results					1512:1518	The results	1508:1518	The results of this study	1508:1532	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	2	42	theme	macro	338:342	arg1	parameters					354:363	the macro geometric parameters	334:363	the macro geometric parameters	334:363	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	11	43	theme	industrial	1592:1601	arg1	application					1603:1613	industrial application	1592:1613	industrial application	1592:1613	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	7	44	theme	porous	1017:1022	arg1	tissue					1036:1041	a porous sponge-like tissue	1015:1041	a porous sponge-like tissue that has a greater bearing capacity while maintaining a low density	1015:1109	The pith is a porous sponge-like tissue that has a greater bearing capacity while maintaining a low density.
33971478	7	44	theme	porous	1017:1022	arg1	pith					1007:1010	The pith	1003:1010	The pith	1003:1010	The pith is a porous sponge-like tissue that has a greater bearing capacity while maintaining a low density.
33971478	2	45	theme	cob	269:271	arg1	microstructure					246:259	microstructure	246:259	microstructure	246:259	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	2	45	theme	cob	269:271	arg1	properties					231:240	mechanical properties	220:240	mechanical properties	220:240	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	5	46	theme	testing	773:779	arg1	machine					781:787	an impact testing machine	763:787	an impact testing machine	763:787	Moreover, an impact testing machine was used for impact tests.
33971478	3	47	used	used	505:508	arg2	Fourier					461:467	The Fourier	457:467	The Fourier transform infrared spectrometer	457:499	The Fourier transform infrared spectrometer was used to analyze the fiber composition, revealing the contribution of fiber composition to the mechanical properties.
33971478	1	48	theme	layered	157:163	arg1	structure					165:173	a special layered structure	147:173	a special layered structure	147:173	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	48	theme	layered	157:163	arg1	properties					132:141	excellent mechanical properties	111:141	excellent mechanical properties	111:141	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	48	theme	layered	157:163	arg1	resource					88:95	a natural biomass resource	70:95	a natural biomass resource	70:95	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	4	49	theme	compression	648:658	arg1	tests					685:689	Axial compression, radial compression, and three-point bending tests	622:689	Axial compression, radial compression, and three-point bending tests	622:689	Axial compression, radial compression, and three-point bending tests were performed on corn cob using a universal testing machine.
33971478	11	50	theme	lightweight	1707:1717	arg1	design					1719:1724	lightweight design	1707:1724	lightweight design	1707:1724	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	3	51	theme	fiber	525:529	arg1	composition					531:541	the fiber composition	521:541	the fiber composition	521:541	The Fourier transform infrared spectrometer was used to analyze the fiber composition, revealing the contribution of fiber composition to the mechanical properties.
33971478	5	52	theme	impact	802:807	arg1	tests					809:813	impact tests	802:813	impact tests	802:813	Moreover, an impact testing machine was used for impact tests.
33971478	2	53	theme	mechanical	220:229	arg1	properties					231:240	mechanical properties	220:240	mechanical properties	220:240	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	8	54	theme	buffering	1168:1176	arg1	properties					1178:1187	good buffering properties	1163:1187	good buffering properties under impact loads	1163:1206	It is also a progressively hardening material with good buffering properties under impact loads.
33971478	4	55	theme	Axial	622:626	arg1	compression					628:638	Axial compression	622:638	Axial compression	622:638	Axial compression, radial compression, and three-point bending tests were performed on corn cob using a universal testing machine.
33971478	8	56	theme	hardening	1139:1147	arg1	It					1112:1113	It	1112:1113	It	1112:1113	It is also a progressively hardening material with good buffering properties under impact loads.
33971478	8	56	theme	hardening	1139:1147	arg1	material					1149:1156	a progressively hardening material	1123:1156	a progressively hardening material with good buffering properties under impact loads	1123:1206	It is also a progressively hardening material with good buffering properties under impact loads.
33971478	6	57	dep	glume	904:908	arg1	composed					918:925	composed	918:925	composed	918:925	The results show that a corn cob is structurally divided into the pith, woody ring, and glume, mainly composed of cellulose, hemicellulose, and lignin in fiber composition, respectively.
33971478	2	58	theme	field	289:293	arg1	microscope					298:307	the ultra-deep field 3D microscope	274:307	the ultra-deep field 3D microscope	274:307	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	8	59	with	material	1149:1156	arg1	properties					1178:1187	good buffering properties	1163:1187	good buffering properties under impact loads	1163:1206	It is also a progressively hardening material with good buffering properties under impact loads.
33971478	11	60	theme	cob	1661:1663	arg1	structure					1643:1651	the unique structure	1632:1651	the unique structure of corn cob	1632:1663	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	11	60	theme	cob	1661:1663	arg1	prototype					1693:1701	an excellent bionic prototype	1673:1701	an excellent bionic prototype for lightweight design	1673:1724	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	0	61	theme	cob	62:64	arg1	properties					43:52	mechanical properties	32:52	mechanical properties of corn cob	32:64	The effect of microstructure on mechanical properties of corn cob.
33971478	3	62	theme	composition	580:590	arg1	contribution					558:569	the contribution	554:569	the contribution of fiber composition to the mechanical properties	554:619	The Fourier transform infrared spectrometer was used to analyze the fiber composition, revealing the contribution of fiber composition to the mechanical properties.
33971478	1	63	theme	excellent	111:119	arg1	structure					165:173	a special layered structure	147:173	a special layered structure	147:173	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	63	theme	excellent	111:119	arg1	properties					132:141	excellent mechanical properties	111:141	excellent mechanical properties	111:141	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	63	theme	excellent	111:119	arg1	resource					88:95	a natural biomass resource	70:95	a natural biomass resource	70:95	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	9	64	theme	woody	1213:1217	arg1	ring					1219:1222	The woody ring	1209:1222	The woody ring	1209:1222	The woody ring is the primary source of mechanical strength, whose microstructure is a hollow tubular structure composed of cellulose and bonded by lignin.
33971478	9	64	theme	woody	1213:1217	arg1	source					1239:1244	the primary source	1227:1244	the primary source	1227:1244	The woody ring is the primary source of mechanical strength, whose microstructure is a hollow tubular structure composed of cellulose and bonded by lignin.
33971478	2	65	theme	cob	452:454	arg1	microstructure					425:438	the microstructure	421:438	the microstructure of the corn cob	421:454	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	0	66	from	effect	4:9	arg1	properties					43:52	mechanical properties	32:52	mechanical properties of corn cob	32:64	The effect of microstructure on mechanical properties of corn cob.
33971478	6	67	from	hemicellulose	941:953	arg1	composition					976:986	fiber composition	970:986	fiber composition	970:986	The results show that a corn cob is structurally divided into the pith, woody ring, and glume, mainly composed of cellulose, hemicellulose, and lignin in fiber composition, respectively.
33971478	4	68	theme	bending	677:683	arg1	tests					685:689	Axial compression, radial compression, and three-point bending tests	622:689	Axial compression, radial compression, and three-point bending tests	622:689	Axial compression, radial compression, and three-point bending tests were performed on corn cob using a universal testing machine.
33971478	11	69	theme	excellent	1676:1684	arg1	structure					1643:1651	the unique structure	1632:1651	the unique structure of corn cob	1632:1663	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	11	69	theme	excellent	1676:1684	arg1	prototype					1693:1701	an excellent bionic prototype	1673:1701	an excellent bionic prototype for lightweight design	1673:1724	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	4	70	theme	testing	736:742	arg1	machine					744:750	a universal testing machine	724:750	a universal testing machine	724:750	Axial compression, radial compression, and three-point bending tests were performed on corn cob using a universal testing machine.
33971478	9	71	theme	primary	1231:1237	arg1	ring					1219:1222	The woody ring	1209:1222	The woody ring	1209:1222	The woody ring is the primary source of mechanical strength, whose microstructure is a hollow tubular structure composed of cellulose and bonded by lignin.
33971478	9	71	theme	primary	1231:1237	arg1	source					1239:1244	the primary source	1227:1244	the primary source	1227:1244	The woody ring is the primary source of mechanical strength, whose microstructure is a hollow tubular structure composed of cellulose and bonded by lignin.
33971478	10	72	theme	the	1396:1398	arg1	porous					1414:1419	porous	1414:1419	porous	1414:1419	The internal microstructure of the glume is also porous and spongy, but the mechanical properties are mainly manifested in its macrostructure.
33971478	10	72	theme	the	1396:1398	arg1	microstructure					1378:1391	The internal microstructure	1365:1391	The internal microstructure of the glume	1365:1404	The internal microstructure of the glume is also porous and spongy, but the mechanical properties are mainly manifested in its macrostructure.
33971478	7	73	theme	low	1099:1101	arg1	density					1103:1109	a low density	1097:1109	a low density	1097:1109	The pith is a porous sponge-like tissue that has a greater bearing capacity while maintaining a low density.
33971478	3	74	dep	transform	469:477	arg1	infrared					479:486	infrared	479:486	transform infrared spectrometer	469:499	The Fourier transform infrared spectrometer was used to analyze the fiber composition, revealing the contribution of fiber composition to the mechanical properties.
33971478	6	75	from	cellulose	930:938	arg1	composition					976:986	fiber composition	970:986	fiber composition	970:986	The results show that a corn cob is structurally divided into the pith, woody ring, and glume, mainly composed of cellulose, hemicellulose, and lignin in fiber composition, respectively.
33971478	0	76	theme	microstructure	14:27	arg1	effect					4:9	The effect	0:9	The effect of microstructure on mechanical properties of corn cob	0:64	The effect of microstructure on mechanical properties of corn cob.
33971478	9	77	theme	strength	1260:1267	arg1	ring					1219:1222	The woody ring	1209:1222	The woody ring	1209:1222	The woody ring is the primary source of mechanical strength, whose microstructure is a hollow tubular structure composed of cellulose and bonded by lignin.
33971478	9	77	theme	strength	1260:1267	arg1	source					1239:1244	the primary source	1227:1244	the primary source	1227:1244	The woody ring is the primary source of mechanical strength, whose microstructure is a hollow tubular structure composed of cellulose and bonded by lignin.
33971478	1	78	theme	biomass	80:86	arg1	structure					165:173	a special layered structure	147:173	a special layered structure	147:173	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	78	theme	biomass	80:86	arg1	properties					132:141	excellent mechanical properties	111:141	excellent mechanical properties	111:141	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	78	theme	biomass	80:86	arg1	resource					88:95	a natural biomass resource	70:95	a natural biomass resource	70:95	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	11	79	theme	corn	1618:1621	arg1	cob					1623:1625	corn cob	1618:1625	corn cob	1618:1625	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	0	80	theme	mechanical	32:41	arg1	properties					43:52	mechanical properties	32:52	mechanical properties of corn cob	32:64	The effect of microstructure on mechanical properties of corn cob.
33971478	6	81	theme	fiber	970:974	arg1	composition					976:986	fiber composition	970:986	fiber composition	970:986	The results show that a corn cob is structurally divided into the pith, woody ring, and glume, mainly composed of cellulose, hemicellulose, and lignin in fiber composition, respectively.
33971478	2	82	theme	electron	383:390	arg1	microscopy					392:401	the scanning electron microscopy	370:401	the scanning electron microscopy (SEM)	370:407	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	2	82	theme	electron	383:390	arg1	SEM					404:406	SEM	404:406	SEM	404:406	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
33971478	7	83	theme	greater	1054:1060	arg1	capacity					1070:1077	a greater bearing capacity	1052:1077	a greater bearing capacity	1052:1077	The pith is a porous sponge-like tissue that has a greater bearing capacity while maintaining a low density.
33971478	11	84	dep	processing	1577:1586	arg1	the					1562:1564	the	1562:1564	the	1562:1564	The results of this study may provide a reference for the subsequent processing and industrial application of corn cob, and the unique structure of corn cob is also an excellent bionic prototype for lightweight design.
33971478	9	85	theme	hollow	1296:1301	arg1	structure					1311:1319	a hollow tubular structure	1294:1319	a hollow tubular structure composed of cellulose and bonded by lignin	1294:1362	The woody ring is the primary source of mechanical strength, whose microstructure is a hollow tubular structure composed of cellulose and bonded by lignin.
33971478	9	85	theme	hollow	1296:1301	arg1	microstructure					1276:1289	microstructure	1276:1289	microstructure	1276:1289	The woody ring is the primary source of mechanical strength, whose microstructure is a hollow tubular structure composed of cellulose and bonded by lignin.
33971478	1	86	contain	has	107:109	arg1	cob					103:105	corn cob	98:105	corn cob	98:105	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	86	contain	has	107:109	arg2	resource					88:95	a natural biomass resource	70:95	a natural biomass resource	70:95	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	86	contain	has	107:109	arg2	properties					132:141	excellent mechanical properties	111:141	excellent mechanical properties	111:141	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	1	86	contain	has	107:109	arg2	structure					165:173	a special layered structure	147:173	a special layered structure	147:173	As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure.
33971478	2	87	theme	geometric	344:352	arg1	parameters					354:363	the macro geometric parameters	334:363	the macro geometric parameters	334:363	To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob.
32059897	0	0	theme	mechanical	100:109	arg1	properties					111:120	balanced mechanical properties	91:120	balanced mechanical properties	91:120	Cellulose nanofibers reinforced biodegradable polyester blends: Ternary biocomposites with balanced mechanical properties.
32059897	6	1	dep	approach	968:975	arg1	processing					987:996	reactive processing	978:996	reactive processing	978:996	To further improve mechanical properties, a two-step approach (reactive processing of blends, followed by the incorporation with nanofibers) was developed.
32059897	0	2	theme	balanced	91:98	arg1	properties					111:120	balanced mechanical properties	91:120	balanced mechanical properties	91:120	Cellulose nanofibers reinforced biodegradable polyester blends: Ternary biocomposites with balanced mechanical properties.
32059897	4	3	theme	driving	690:696	arg1	nanofibers					698:707	driving nanofibers	690:707	driving nanofibers	690:707	It is found that most nanofibers are dispersed in the polylactide phase because polylactide has better affinity to nanofibers, and the lower viscosity level of polylactide also favors driving nanofibers into the continuous polylactide phase during melting mixing.
32059897	6	4	theme	reactive	978:985	arg1	processing					987:996	reactive processing	978:996	reactive processing	978:996	To further improve mechanical properties, a two-step approach (reactive processing of blends, followed by the incorporation with nanofibers) was developed.
32059897	5	5	theme	phase	877:881	arg1	presence					835:842	the presence	831:842	the presence of soft poly(butylene succinate) phase	831:881	In this case, the strength and rigidity losses resulted from the presence of soft poly(butylene succinate) phase are compensated to some extent.
32059897	7	6	theme	interesting	1093:1103	arg1	way					1105:1107	an interesting way	1090:1107	an interesting way of fabricating fully biodegradable composites with well-balanced mechanical performance	1090:1195	This work provides an interesting way of fabricating fully biodegradable composites with well-balanced mechanical performance.
32059897	1	7	with	polyesters	160:169	arg1	properties					195:204	complementary bulk properties	176:204	complementary bulk properties	176:204	Blending two biodegradable aliphatic polyesters with complementary bulk properties is an easy way of tuning their final properties.
32059897	0	8	with	biocomposites	72:84	arg1	properties					111:120	balanced mechanical properties	91:120	balanced mechanical properties	91:120	Cellulose nanofibers reinforced biodegradable polyester blends: Ternary biocomposites with balanced mechanical properties.
32059897	2	9	theme	butylene	286:293	arg1	succinate					295:303	butylene succinate	286:303	butylene succinate	286:303	In this work, the ductile poly(butylene succinate) was mixed with polylactide, and as expectable, the blends show improved toughness with sharply reduced strengths.
32059897	2	9	theme	butylene	286:293	arg1	poly					281:284	the ductile poly	269:284	the ductile poly(butylene succinate)	269:304	In this work, the ductile poly(butylene succinate) was mixed with polylactide, and as expectable, the blends show improved toughness with sharply reduced strengths.
32059897	4	10	theme	polylactide	666:676	arg1	level					657:661	the lower viscosity level	637:661	the lower viscosity level of polylactide	637:676	It is found that most nanofibers are dispersed in the polylactide phase because polylactide has better affinity to nanofibers, and the lower viscosity level of polylactide also favors driving nanofibers into the continuous polylactide phase during melting mixing.
32059897	5	11	theme	poly	852:855	arg1	phase					877:881	soft poly(butylene succinate) phase	847:881	soft poly(butylene succinate) phase	847:881	In this case, the strength and rigidity losses resulted from the presence of soft poly(butylene succinate) phase are compensated to some extent.
32059897	1	12	theme	easy	212:215	arg1	way					217:219	an easy way	209:219	an easy way of tuning their final properties	209:252	Blending two biodegradable aliphatic polyesters with complementary bulk properties is an easy way of tuning their final properties.
32059897	5	13	theme	rigidity	801:808	arg1	losses					810:815	the strength and rigidity losses	784:815	the strength and rigidity losses	784:815	In this case, the strength and rigidity losses resulted from the presence of soft poly(butylene succinate) phase are compensated to some extent.
32059897	3	14	used	used	464:467	arg2	reinforcement					476:488	the reinforcement	472:488	the reinforcement for the blends	472:503	The pristine cellulose nanofibers were then used as the reinforcement for the blends.
32059897	3	14	used	used	464:467	arg2	nanofibers					443:452	The pristine cellulose nanofibers	420:452	The pristine cellulose nanofibers	420:452	The pristine cellulose nanofibers were then used as the reinforcement for the blends.
32059897	7	15	theme	mechanical	1174:1183	arg1	performance					1185:1195	well-balanced mechanical performance	1160:1195	well-balanced mechanical performance	1160:1195	This work provides an interesting way of fabricating fully biodegradable composites with well-balanced mechanical performance.
32059897	3	16	theme	pristine	424:431	arg1	nanofibers					443:452	The pristine cellulose nanofibers	420:452	The pristine cellulose nanofibers	420:452	The pristine cellulose nanofibers were then used as the reinforcement for the blends.
32059897	3	16	theme	pristine	424:431	arg1	reinforcement					476:488	the reinforcement	472:488	the reinforcement for the blends	472:503	The pristine cellulose nanofibers were then used as the reinforcement for the blends.
32059897	0	17	theme	Cellulose	0:8	arg1	nanofibers					10:19	Cellulose nanofibers	0:19	Cellulose nanofibers	0:19	Cellulose nanofibers reinforced biodegradable polyester blends: Ternary biocomposites with balanced mechanical properties.
32059897	6	18	theme	two-step	959:966	arg1	approach					968:975	a two-step approach	957:975	a two-step approach (reactive processing of blends, followed by the incorporation with nanofibers)	957:1054	To further improve mechanical properties, a two-step approach (reactive processing of blends, followed by the incorporation with nanofibers) was developed.
32059897	6	19	with	incorporation	1025:1037	arg1	nanofibers					1044:1053	nanofibers	1044:1053	nanofibers	1044:1053	To further improve mechanical properties, a two-step approach (reactive processing of blends, followed by the incorporation with nanofibers) was developed.
32059897	2	20	theme	improved	369:376	arg1	toughness					378:386	improved toughness	369:386	improved toughness with sharply reduced strengths	369:417	In this work, the ductile poly(butylene succinate) was mixed with polylactide, and as expectable, the blends show improved toughness with sharply reduced strengths.
32059897	0	21	theme	biodegradable	32:44	arg1	blends					56:61	biodegradable polyester blends	32:61	biodegradable polyester blends: Ternary biocomposites with balanced mechanical properties	32:120	Cellulose nanofibers reinforced biodegradable polyester blends: Ternary biocomposites with balanced mechanical properties.
32059897	1	22	theme	tuning	224:229	arg1	properties					243:252	tuning their final properties	224:252	tuning their final properties	224:252	Blending two biodegradable aliphatic polyesters with complementary bulk properties is an easy way of tuning their final properties.
32059897	7	23	theme	well-balanced	1160:1172	arg1	performance					1185:1195	well-balanced mechanical performance	1160:1195	well-balanced mechanical performance	1160:1195	This work provides an interesting way of fabricating fully biodegradable composites with well-balanced mechanical performance.
32059897	4	24	theme	polylactide	560:570	arg1	phase					572:576	the polylactide phase	556:576	the polylactide phase	556:576	It is found that most nanofibers are dispersed in the polylactide phase because polylactide has better affinity to nanofibers, and the lower viscosity level of polylactide also favors driving nanofibers into the continuous polylactide phase during melting mixing.
32059897	4	25	theme	melting	754:760	arg1	mixing					762:767	melting mixing	754:767	melting mixing	754:767	It is found that most nanofibers are dispersed in the polylactide phase because polylactide has better affinity to nanofibers, and the lower viscosity level of polylactide also favors driving nanofibers into the continuous polylactide phase during melting mixing.
32059897	7	26	theme	biodegradable	1130:1142	arg1	composites					1144:1153	fully biodegradable composites	1124:1153	fully biodegradable composites	1124:1153	This work provides an interesting way of fabricating fully biodegradable composites with well-balanced mechanical performance.
32059897	4	27	theme	lower	641:645	arg1	level					657:661	the lower viscosity level	637:661	the lower viscosity level of polylactide	637:676	It is found that most nanofibers are dispersed in the polylactide phase because polylactide has better affinity to nanofibers, and the lower viscosity level of polylactide also favors driving nanofibers into the continuous polylactide phase during melting mixing.
32059897	3	28	theme	cellulose	433:441	arg1	nanofibers					443:452	The pristine cellulose nanofibers	420:452	The pristine cellulose nanofibers	420:452	The pristine cellulose nanofibers were then used as the reinforcement for the blends.
32059897	3	28	theme	cellulose	433:441	arg1	reinforcement					476:488	the reinforcement	472:488	the reinforcement for the blends	472:503	The pristine cellulose nanofibers were then used as the reinforcement for the blends.
32059897	1	29	theme	final	237:241	arg1	properties					243:252	tuning their final properties	224:252	tuning their final properties	224:252	Blending two biodegradable aliphatic polyesters with complementary bulk properties is an easy way of tuning their final properties.
32059897	0	30	theme	polyester	46:54	arg1	blends					56:61	biodegradable polyester blends	32:61	biodegradable polyester blends: Ternary biocomposites with balanced mechanical properties	32:120	Cellulose nanofibers reinforced biodegradable polyester blends: Ternary biocomposites with balanced mechanical properties.
32059897	4	31	theme	most	523:526	arg1	nanofibers					528:537	most nanofibers	523:537	most nanofibers	523:537	It is found that most nanofibers are dispersed in the polylactide phase because polylactide has better affinity to nanofibers, and the lower viscosity level of polylactide also favors driving nanofibers into the continuous polylactide phase during melting mixing.
32059897	5	32	theme	butylene	857:864	arg1	phase					877:881	soft poly(butylene succinate) phase	847:881	soft poly(butylene succinate) phase	847:881	In this case, the strength and rigidity losses resulted from the presence of soft poly(butylene succinate) phase are compensated to some extent.
32059897	4	33	contain	has	598:600	arg1	polylactide					586:596	polylactide	586:596	polylactide	586:596	It is found that most nanofibers are dispersed in the polylactide phase because polylactide has better affinity to nanofibers, and the lower viscosity level of polylactide also favors driving nanofibers into the continuous polylactide phase during melting mixing.
32059897	4	33	contain	has	598:600	arg2	affinity					609:616	better affinity	602:616	better affinity to nanofibers	602:630	It is found that most nanofibers are dispersed in the polylactide phase because polylactide has better affinity to nanofibers, and the lower viscosity level of polylactide also favors driving nanofibers into the continuous polylactide phase during melting mixing.
32059897	5	34	theme	soft	847:850	arg1	phase					877:881	soft poly(butylene succinate) phase	847:881	soft poly(butylene succinate) phase	847:881	In this case, the strength and rigidity losses resulted from the presence of soft poly(butylene succinate) phase are compensated to some extent.
32059897	2	35	theme	reduced	401:407	arg1	strengths					409:417	sharply reduced strengths	393:417	sharply reduced strengths	393:417	In this work, the ductile poly(butylene succinate) was mixed with polylactide, and as expectable, the blends show improved toughness with sharply reduced strengths.
32059897	0	36	theme	Ternary	64:70	arg1	biocomposites					72:84	Ternary biocomposites	64:84	biodegradable polyester blends: Ternary biocomposites with balanced mechanical properties	32:120	Cellulose nanofibers reinforced biodegradable polyester blends: Ternary biocomposites with balanced mechanical properties.
32059897	6	37	theme	mechanical	934:943	arg1	properties					945:954	mechanical properties	934:954	mechanical properties	934:954	To further improve mechanical properties, a two-step approach (reactive processing of blends, followed by the incorporation with nanofibers) was developed.
32059897	0	38	dep	blends	56:61	arg1	biocomposites					72:84	Ternary biocomposites	64:84	biodegradable polyester blends: Ternary biocomposites with balanced mechanical properties	32:120	Cellulose nanofibers reinforced biodegradable polyester blends: Ternary biocomposites with balanced mechanical properties.
32059897	1	39	theme	biodegradable	136:148	arg1	polyesters					160:169	two biodegradable aliphatic polyesters	132:169	two biodegradable aliphatic polyesters with complementary bulk properties	132:204	Blending two biodegradable aliphatic polyesters with complementary bulk properties is an easy way of tuning their final properties.
32059897	1	40	theme	aliphatic	150:158	arg1	polyesters					160:169	two biodegradable aliphatic polyesters	132:169	two biodegradable aliphatic polyesters with complementary bulk properties	132:204	Blending two biodegradable aliphatic polyesters with complementary bulk properties is an easy way of tuning their final properties.
32059897	4	41	theme	polylactide	729:739	arg1	phase					741:745	the continuous polylactide phase	714:745	the continuous polylactide phase during melting mixing	714:767	It is found that most nanofibers are dispersed in the polylactide phase because polylactide has better affinity to nanofibers, and the lower viscosity level of polylactide also favors driving nanofibers into the continuous polylactide phase during melting mixing.
32059897	5	42	theme	succinate	866:874	arg1	phase					877:881	soft poly(butylene succinate) phase	847:881	soft poly(butylene succinate) phase	847:881	In this case, the strength and rigidity losses resulted from the presence of soft poly(butylene succinate) phase are compensated to some extent.
32059897	2	43	theme	ductile	273:279	arg1	succinate					295:303	butylene succinate	286:303	butylene succinate	286:303	In this work, the ductile poly(butylene succinate) was mixed with polylactide, and as expectable, the blends show improved toughness with sharply reduced strengths.
32059897	2	43	theme	ductile	273:279	arg1	poly					281:284	the ductile poly	269:284	the ductile poly(butylene succinate)	269:304	In this work, the ductile poly(butylene succinate) was mixed with polylactide, and as expectable, the blends show improved toughness with sharply reduced strengths.
32059897	4	44	theme	continuous	718:727	arg1	phase					741:745	the continuous polylactide phase	714:745	the continuous polylactide phase during melting mixing	714:767	It is found that most nanofibers are dispersed in the polylactide phase because polylactide has better affinity to nanofibers, and the lower viscosity level of polylactide also favors driving nanofibers into the continuous polylactide phase during melting mixing.
32059897	4	45	theme	better	602:607	arg1	affinity					609:616	better affinity	602:616	better affinity to nanofibers	602:630	It is found that most nanofibers are dispersed in the polylactide phase because polylactide has better affinity to nanofibers, and the lower viscosity level of polylactide also favors driving nanofibers into the continuous polylactide phase during melting mixing.
32059897	1	46	theme	properties	243:252	arg1	way					217:219	an easy way	209:219	an easy way of tuning their final properties	209:252	Blending two biodegradable aliphatic polyesters with complementary bulk properties is an easy way of tuning their final properties.
32059897	1	47	theme	complementary	176:188	arg1	properties					195:204	complementary bulk properties	176:204	complementary bulk properties	176:204	Blending two biodegradable aliphatic polyesters with complementary bulk properties is an easy way of tuning their final properties.
32059897	4	48	theme	viscosity	647:655	arg1	level					657:661	the lower viscosity level	637:661	the lower viscosity level of polylactide	637:676	It is found that most nanofibers are dispersed in the polylactide phase because polylactide has better affinity to nanofibers, and the lower viscosity level of polylactide also favors driving nanofibers into the continuous polylactide phase during melting mixing.
32059897	6	49	theme	blends	1001:1006	arg1	processing					987:996	reactive processing	978:996	reactive processing	978:996	To further improve mechanical properties, a two-step approach (reactive processing of blends, followed by the incorporation with nanofibers) was developed.
32059897	5	50	theme	strength	788:795	arg1	losses					810:815	the strength and rigidity losses	784:815	the strength and rigidity losses	784:815	In this case, the strength and rigidity losses resulted from the presence of soft poly(butylene succinate) phase are compensated to some extent.
32059897	2	51	with	toughness	378:386	arg1	strengths					409:417	sharply reduced strengths	393:417	sharply reduced strengths	393:417	In this work, the ductile poly(butylene succinate) was mixed with polylactide, and as expectable, the blends show improved toughness with sharply reduced strengths.
32059897	1	52	theme	bulk	190:193	arg1	properties					195:204	complementary bulk properties	176:204	complementary bulk properties	176:204	Blending two biodegradable aliphatic polyesters with complementary bulk properties is an easy way of tuning their final properties.
33373842	2	0	theme	Atomic	525:530	arg1	Microscopy					538:547	Atomic Force Microscopy	525:547	Atomic Force Microscopy	525:547	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	1	1	theme	multilayer	185:194	arg1	films					202:206	polysaccharide-based polyelectrolyte multilayer (PEM) films	148:206	polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications	148:261	This study presents the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications.
33373842	5	2	theme	spatio-temporal	1120:1134	arg1	behavior					1136:1143	controlled spatio-temporal behavior	1109:1143	controlled spatio-temporal behavior	1109:1143	The interplay of bulk film composition and surface properties may provide valuable insights for engineering advanced materials with controlled spatio-temporal behavior.
33373842	5	3	theme	composition	1004:1014	arg1	interplay					981:989	The interplay	977:989	The interplay of bulk film composition and surface properties	977:1037	The interplay of bulk film composition and surface properties may provide valuable insights for engineering advanced materials with controlled spatio-temporal behavior.
33373842	3	4	theme	metal	717:721	arg1	distribution					723:734	a nearly uniform metal distribution	700:734	a nearly uniform metal distribution over the axial direction	700:759	Despite the use of the layer-by-layer approach for film assembly, these PEM films present a non-stratified, nanoblend-like, polymer composition, with a nearly uniform metal distribution over the axial direction.
33373842	5	5	with	materials	1094:1102	arg1	behavior					1136:1143	controlled spatio-temporal behavior	1109:1143	controlled spatio-temporal behavior	1109:1143	The interplay of bulk film composition and surface properties may provide valuable insights for engineering advanced materials with controlled spatio-temporal behavior.
33373842	3	6	theme	layer-by-layer	573:586	arg1	approach					588:595	the layer-by-layer approach	569:595	the layer-by-layer approach for film assembly	569:613	Despite the use of the layer-by-layer approach for film assembly, these PEM films present a non-stratified, nanoblend-like, polymer composition, with a nearly uniform metal distribution over the axial direction.
33373842	4	7	theme	surface	780:786	arg1	activity					802:809	surface antimicrobial activity	780:809	surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi	780:875	Results also show surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi over 20 h for hyaluronan/chitosan PEM, which is associated with its higher silver loading capacity.
33373842	5	8	theme	surface	1020:1026	arg1	properties					1028:1037	surface properties	1020:1037	surface properties	1020:1037	The interplay of bulk film composition and surface properties may provide valuable insights for engineering advanced materials with controlled spatio-temporal behavior.
33373842	3	9	theme	approach	588:595	arg1	use					562:564	the use	558:564	the use of the layer-by-layer approach for film assembly	558:613	Despite the use of the layer-by-layer approach for film assembly, these PEM films present a non-stratified, nanoblend-like, polymer composition, with a nearly uniform metal distribution over the axial direction.
33373842	1	10	theme	axial	121:125	arg1	composition					133:143	the axial molar composition	117:143	the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications	117:261	This study presents the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications.
33373842	4	11	theme	hyaluronan/chitosan	891:909	arg1	PEM					911:913	hyaluronan/chitosan PEM	891:913	hyaluronan/chitosan PEM	891:913	Results also show surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi over 20 h for hyaluronan/chitosan PEM, which is associated with its higher silver loading capacity.
33373842	3	12	dep	non-stratified	642:655	arg1	nanoblend-like					658:671	nanoblend-like	658:671	nanoblend-like	658:671	Despite the use of the layer-by-layer approach for film assembly, these PEM films present a non-stratified, nanoblend-like, polymer composition, with a nearly uniform metal distribution over the axial direction.
33373842	5	13	theme	properties	1028:1037	arg1	interplay					981:989	The interplay	977:989	The interplay of bulk film composition and surface properties	977:1037	The interplay of bulk film composition and surface properties may provide valuable insights for engineering advanced materials with controlled spatio-temporal behavior.
33373842	2	14	theme	ion	423:425	arg1	technique					438:446	C60+ cluster ion sputtering technique	410:446	C60+ cluster ion sputtering technique	410:446	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	1	15	theme	PEM	197:199	arg1	films					202:206	polysaccharide-based polyelectrolyte multilayer (PEM) films	148:206	polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications	148:261	This study presents the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications.
33373842	0	16	theme	layer-by-layer	53:66	arg1	films					68:72	biopolymer-based layer-by-layer films	36:72	biopolymer-based layer-by-layer films for antimicrobial use	36:94	Probing axial metal distribution on biopolymer-based layer-by-layer films for antimicrobial use.
33373842	3	17	theme	axial	745:749	arg1	direction					751:759	the axial direction	741:759	the axial direction	741:759	Despite the use of the layer-by-layer approach for film assembly, these PEM films present a non-stratified, nanoblend-like, polymer composition, with a nearly uniform metal distribution over the axial direction.
33373842	4	18	theme	Staphylococcus	819:832	arg1	bacteria					841:848	Staphylococcus aureus bacteria	819:848	Staphylococcus aureus bacteria	819:848	Results also show surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi over 20 h for hyaluronan/chitosan PEM, which is associated with its higher silver loading capacity.
33373842	2	19	theme	sputtering	427:436	arg1	technique					438:446	C60+ cluster ion sputtering technique	410:446	C60+ cluster ion sputtering technique	410:446	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	0	20	theme	axial	8:12	arg1	distribution					20:31	axial metal distribution	8:31	axial metal distribution	8:31	Probing axial metal distribution on biopolymer-based layer-by-layer films for antimicrobial use.
33373842	5	21	theme	film	999:1002	arg1	composition					1004:1014	bulk film composition	994:1014	bulk film composition	994:1014	The interplay of bulk film composition and surface properties may provide valuable insights for engineering advanced materials with controlled spatio-temporal behavior.
33373842	1	22	theme	films	202:206	arg1	composition					133:143	the axial molar composition	117:143	the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications	117:261	This study presents the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications.
33373842	2	23	theme	loading	479:485	arg1	influence					459:467	the influence	455:467	the influence of silver loading on film topography	455:504	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	5	24	theme	bulk	994:997	arg1	composition					1004:1014	bulk film composition	994:1014	bulk film composition	994:1014	The interplay of bulk film composition and surface properties may provide valuable insights for engineering advanced materials with controlled spatio-temporal behavior.
33373842	2	25	theme	cluster	415:421	arg1	technique					438:446	C60+ cluster ion sputtering technique	410:446	C60+ cluster ion sputtering technique	410:446	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	2	26	theme	silver	472:477	arg1	loading					479:485	silver loading	472:485	silver loading	472:485	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	2	27	theme	silver	323:328	arg1	composition					330:340	silver composition	323:340	silver composition	323:340	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	0	28	theme	metal	14:18	arg1	distribution					20:31	axial metal distribution	8:31	axial metal distribution	8:31	Probing axial metal distribution on biopolymer-based layer-by-layer films for antimicrobial use.
33373842	2	29	theme	C60+	410:413	arg1	technique					438:446	C60+ cluster ion sputtering technique	410:446	C60+ cluster ion sputtering technique	410:446	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	3	30	theme	film	601:604	arg1	assembly					606:613	film assembly	601:613	film assembly	601:613	Despite the use of the layer-by-layer approach for film assembly, these PEM films present a non-stratified, nanoblend-like, polymer composition, with a nearly uniform metal distribution over the axial direction.
33373842	1	31	theme	silver	220:225	arg1	ions					227:230	silver ions	220:230	silver ions for antimicrobial applications	220:261	This study presents the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications.
33373842	0	32	theme	biopolymer-based	36:51	arg1	films					68:72	biopolymer-based layer-by-layer films	36:72	biopolymer-based layer-by-layer films for antimicrobial use	36:94	Probing axial metal distribution on biopolymer-based layer-by-layer films for antimicrobial use.
33373842	2	33	theme	X-Ray	364:368	arg1	Spectroscopy					384:395	X-Ray Photoelectron Spectroscopy	364:395	X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique	364:446	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	2	34	theme	Individual	264:273	arg1	alginate					309:316	alginate	309:316	alginate	309:316	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	2	34	theme	Individual	264:273	arg1	hyaluronan					295:304	hyaluronan	295:304	hyaluronan	295:304	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	2	34	theme	Individual	264:273	arg1	chitosan					285:292	chitosan	285:292	chitosan	285:292	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	2	34	theme	Individual	264:273	arg1	polymers					275:282	Individual polymers	264:282	Individual polymers (chitosan, hyaluronan or alginate)	264:317	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	4	35	dep	bacteria	841:848	arg1	fungi					871:875	fungi	871:875	fungi	871:875	Results also show surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi over 20 h for hyaluronan/chitosan PEM, which is associated with its higher silver loading capacity.
33373842	5	36	theme	advanced	1085:1092	arg1	materials					1094:1102	advanced materials	1085:1102	advanced materials with controlled spatio-temporal behavior	1085:1143	The interplay of bulk film composition and surface properties may provide valuable insights for engineering advanced materials with controlled spatio-temporal behavior.
33373842	4	37	theme	higher	945:950	arg1	capacity					967:974	its higher silver loading capacity	941:974	its higher silver loading capacity	941:974	Results also show surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi over 20 h for hyaluronan/chitosan PEM, which is associated with its higher silver loading capacity.
33373842	3	38	theme	polymer	674:680	arg1	composition					682:692	a non-stratified, nanoblend-like, polymer composition	640:692	a non-stratified, nanoblend-like, polymer composition	640:692	Despite the use of the layer-by-layer approach for film assembly, these PEM films present a non-stratified, nanoblend-like, polymer composition, with a nearly uniform metal distribution over the axial direction.
33373842	2	39	theme	Photoelectron	370:382	arg1	Spectroscopy					384:395	X-Ray Photoelectron Spectroscopy	364:395	X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique	364:446	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	2	40	theme	film	490:493	arg1	topography					495:504	film topography	490:504	film topography	490:504	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	5	41	theme	controlled	1109:1118	arg1	behavior					1136:1143	controlled spatio-temporal behavior	1109:1143	controlled spatio-temporal behavior	1109:1143	The interplay of bulk film composition and surface properties may provide valuable insights for engineering advanced materials with controlled spatio-temporal behavior.
33373842	3	42	theme	PEM	622:624	arg1	films					626:630	these PEM films	616:630	these PEM films	616:630	Despite the use of the layer-by-layer approach for film assembly, these PEM films present a non-stratified, nanoblend-like, polymer composition, with a nearly uniform metal distribution over the axial direction.
33373842	1	43	theme	molar	127:131	arg1	composition					133:143	the axial molar composition	117:143	the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications	117:261	This study presents the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications.
33373842	4	44	theme	Candida	854:860	arg1	albicans					862:869	Candida albicans	854:869	Candida albicans	854:869	Results also show surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi over 20 h for hyaluronan/chitosan PEM, which is associated with its higher silver loading capacity.
33373842	4	45	theme	loading	959:965	arg1	capacity					967:974	its higher silver loading capacity	941:974	its higher silver loading capacity	941:974	Results also show surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi over 20 h for hyaluronan/chitosan PEM, which is associated with its higher silver loading capacity.
33373842	3	46	theme	uniform	709:715	arg1	distribution					723:734	a nearly uniform metal distribution	700:734	a nearly uniform metal distribution over the axial direction	700:759	Despite the use of the layer-by-layer approach for film assembly, these PEM films present a non-stratified, nanoblend-like, polymer composition, with a nearly uniform metal distribution over the axial direction.
33373842	4	47	theme	antimicrobial	788:800	arg1	activity					802:809	surface antimicrobial activity	780:809	surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi	780:875	Results also show surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi over 20 h for hyaluronan/chitosan PEM, which is associated with its higher silver loading capacity.
33373842	1	48	theme	antimicrobial	236:248	arg1	applications					250:261	antimicrobial applications	236:261	antimicrobial applications	236:261	This study presents the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications.
33373842	4	49	theme	silver	952:957	arg1	capacity					967:974	its higher silver loading capacity	941:974	its higher silver loading capacity	941:974	Results also show surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi over 20 h for hyaluronan/chitosan PEM, which is associated with its higher silver loading capacity.
33373842	5	50	theme	valuable	1051:1058	arg1	insights					1060:1067	valuable insights	1051:1067	valuable insights	1051:1067	The interplay of bulk film composition and surface properties may provide valuable insights for engineering advanced materials with controlled spatio-temporal behavior.
33373842	4	51	dep	Staphylococcus	819:832	arg1	aureus					834:839	aureus	834:839	aureus	834:839	Results also show surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi over 20 h for hyaluronan/chitosan PEM, which is associated with its higher silver loading capacity.
33373842	0	52	theme	antimicrobial	78:90	arg1	use					92:94	antimicrobial use	78:94	antimicrobial use	78:94	Probing axial metal distribution on biopolymer-based layer-by-layer films for antimicrobial use.
33373842	1	53	theme	polysaccharide-based	148:167	arg1	films					202:206	polysaccharide-based polyelectrolyte multilayer (PEM) films	148:206	polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications	148:261	This study presents the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications.
33373842	2	54	dep	polymers	275:282	arg1	alginate					309:316	alginate	309:316	alginate	309:316	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	2	54	dep	polymers	275:282	arg1	hyaluronan					295:304	hyaluronan	295:304	hyaluronan	295:304	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	2	54	dep	polymers	275:282	arg1	chitosan					285:292	chitosan	285:292	chitosan	285:292	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	2	54	dep	polymers	275:282	arg1	polymers					275:282	Individual polymers	264:282	Individual polymers (chitosan, hyaluronan or alginate)	264:317	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	2	55	theme	Force	532:536	arg1	Microscopy					538:547	Atomic Force Microscopy	525:547	Atomic Force Microscopy	525:547	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	3	56	theme	non-stratified	642:655	arg1	composition					682:692	a non-stratified, nanoblend-like, polymer composition	640:692	a non-stratified, nanoblend-like, polymer composition	640:692	Despite the use of the layer-by-layer approach for film assembly, these PEM films present a non-stratified, nanoblend-like, polymer composition, with a nearly uniform metal distribution over the axial direction.
33373842	2	57	from	influence	459:467	arg1	topography					495:504	film topography	490:504	film topography	490:504	Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C60+ cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy.
33373842	1	58	theme	polyelectrolyte	169:183	arg1	films					202:206	polysaccharide-based polyelectrolyte multilayer (PEM) films	148:206	polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications	148:261	This study presents the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications.
33326188	0	0	theme	Anaplastic	83:92	arg1	Theranostics					112:123	Anaplastic Thyroid Carcinoma Theranostics	83:123	Anaplastic Thyroid Carcinoma Theranostics	83:123	Co-Delivery of 131 I and Prima-1 by Self-Assembled CD44-Targeted Nanoparticles for Anaplastic Thyroid Carcinoma Theranostics.
33326188	4	1	theme	acid	722:725	arg1	PEI					751:753	PEI	751:753	PEI	751:753	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
33326188	4	1	theme	acid	722:725	arg1	-polyethyleneimine					731:748	tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine	696:748	tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI)	696:754	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
33326188	5	2	theme	tumor	892:896	arg1	imaging					898:904	an impressive tumor imaging	878:904	an impressive tumor imaging as well as a long radiation treatment cycle	878:948	The 125 I-labeled nanocomposites display an impressive tumor imaging as well as a long radiation treatment cycle.
33326188	1	3	theme	new	196:198	arg1	opportunities					200:212	new opportunities	196:212	new opportunities for tumor treatment and imaging	196:244	New radionuclide-labeled targeting nanocarrier systems have generated new opportunities for tumor treatment and imaging.
33326188	6	4	theme	remarkable	988:997	arg1	effects					1014:1020	remarkable anti ATC-tumor effects	988:1020	remarkable anti ATC-tumor effects	988:1020	The 131 I-labeled nanoparticles show remarkable anti ATC-tumor effects in vitro and in vivo, due to radiosensitization of Prima-1 by reactivation of the p53 mutants.
33326188	0	5	theme	Carcinoma	102:110	arg1	Theranostics					112:123	Anaplastic Thyroid Carcinoma Theranostics	83:123	Anaplastic Thyroid Carcinoma Theranostics	83:123	Co-Delivery of 131 I and Prima-1 by Self-Assembled CD44-Targeted Nanoparticles for Anaplastic Thyroid Carcinoma Theranostics.
33326188	6	6	dep	remarkable	988:997	arg1	anti					999:1002	anti	999:1002	anti	999:1002	The 131 I-labeled nanoparticles show remarkable anti ATC-tumor effects in vitro and in vivo, due to radiosensitization of Prima-1 by reactivation of the p53 mutants.
33326188	5	7	theme	impressive	881:890	arg1	imaging					898:904	an impressive tumor imaging	878:904	an impressive tumor imaging as well as a long radiation treatment cycle	878:948	The 125 I-labeled nanocomposites display an impressive tumor imaging as well as a long radiation treatment cycle.
33326188	0	8	theme	Thyroid	94:100	arg1	Theranostics					112:123	Anaplastic Thyroid Carcinoma Theranostics	83:123	Anaplastic Thyroid Carcinoma Theranostics	83:123	Co-Delivery of 131 I and Prima-1 by Self-Assembled CD44-Targeted Nanoparticles for Anaplastic Thyroid Carcinoma Theranostics.
33326188	2	9	theme	carcinoma	334:342	arg1	patients					350:357	anaplastic thyroid carcinoma (ATC) patients	315:357	anaplastic thyroid carcinoma (ATC) patients	315:357	Nevertheless, such therapeutic strategy is clinically unfeasible on anaplastic thyroid carcinoma (ATC) patients, because of lacking suitable targets and resistance to radiation.
33326188	3	10	theme	ATC	523:525	arg1	species					534:540	human ATC tissue species	517:540	human ATC tissue species	517:540	In order to figure out a potential treatment, immuno-histochemical staining is performed in human ATC tissue species and high expression of cluster determinant 44 (CD44) is found.
33326188	4	11	theme	-hyaluronic	710:720	arg1	HA					728:729	HA	728:729	HA	728:729	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
33326188	4	11	theme	-hyaluronic	710:720	arg1	acid					722:725	tyrosine (Tyr)-hyaluronic acid	696:725	tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI)	696:754	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
33326188	2	12	theme	suitable	379:386	arg1	targets					388:394	lacking suitable targets	371:394	lacking suitable targets	371:394	Nevertheless, such therapeutic strategy is clinically unfeasible on anaplastic thyroid carcinoma (ATC) patients, because of lacking suitable targets and resistance to radiation.
33326188	2	13	theme	thyroid	326:332	arg1	carcinoma					334:342	anaplastic thyroid carcinoma	315:342	anaplastic thyroid carcinoma (ATC) patients	315:357	Nevertheless, such therapeutic strategy is clinically unfeasible on anaplastic thyroid carcinoma (ATC) patients, because of lacking suitable targets and resistance to radiation.
33326188	2	13	theme	thyroid	326:332	arg1	ATC					345:347	ATC	345:347	ATC	345:347	Nevertheless, such therapeutic strategy is clinically unfeasible on anaplastic thyroid carcinoma (ATC) patients, because of lacking suitable targets and resistance to radiation.
33326188	3	14	theme	potential	450:458	arg1	treatment					460:468	a potential treatment	448:468	a potential treatment	448:468	In order to figure out a potential treatment, immuno-histochemical staining is performed in human ATC tissue species and high expression of cluster determinant 44 (CD44) is found.
33326188	6	15	theme	p53	1104:1106	arg1	mutants					1108:1114	the p53 mutants	1100:1114	the p53 mutants	1100:1114	The 131 I-labeled nanoparticles show remarkable anti ATC-tumor effects in vitro and in vivo, due to radiosensitization of Prima-1 by reactivation of the p53 mutants.
33326188	2	16	theme	anaplastic	315:324	arg1	carcinoma					334:342	anaplastic thyroid carcinoma	315:342	anaplastic thyroid carcinoma (ATC) patients	315:357	Nevertheless, such therapeutic strategy is clinically unfeasible on anaplastic thyroid carcinoma (ATC) patients, because of lacking suitable targets and resistance to radiation.
33326188	2	16	theme	anaplastic	315:324	arg1	ATC					345:347	ATC	345:347	ATC	345:347	Nevertheless, such therapeutic strategy is clinically unfeasible on anaplastic thyroid carcinoma (ATC) patients, because of lacking suitable targets and resistance to radiation.
33326188	3	17	theme	tissue	527:532	arg1	species					534:540	human ATC tissue species	517:540	human ATC tissue species	517:540	In order to figure out a potential treatment, immuno-histochemical staining is performed in human ATC tissue species and high expression of cluster determinant 44 (CD44) is found.
33326188	3	18	theme	immuno-histochemical	471:490	arg1	staining					492:499	immuno-histochemical staining	471:499	immuno-histochemical staining	471:499	In order to figure out a potential treatment, immuno-histochemical staining is performed in human ATC tissue species and high expression of cluster determinant 44 (CD44) is found.
33326188	5	19	theme	long	919:922	arg1	cycle					944:948	a long radiation treatment cycle	917:948	an impressive tumor imaging as well as a long radiation treatment cycle	878:948	The 125 I-labeled nanocomposites display an impressive tumor imaging as well as a long radiation treatment cycle.
33326188	6	20	theme	Prima-1	1073:1079	arg1	radiosensitization					1051:1068	radiosensitization	1051:1068	radiosensitization of Prima-1	1051:1079	The 131 I-labeled nanoparticles show remarkable anti ATC-tumor effects in vitro and in vivo, due to radiosensitization of Prima-1 by reactivation of the p53 mutants.
33326188	1	21	theme	tumor	218:222	arg1	treatment					224:232	tumor treatment	218:232	tumor treatment	218:232	New radionuclide-labeled targeting nanocarrier systems have generated new opportunities for tumor treatment and imaging.
33326188	6	22	theme	I-labeled	959:967	arg1	nanoparticles					969:981	The 131 I-labeled nanoparticles	951:981	The 131 I-labeled nanoparticles	951:981	The 131 I-labeled nanoparticles show remarkable anti ATC-tumor effects in vitro and in vivo, due to radiosensitization of Prima-1 by reactivation of the p53 mutants.
33326188	5	23	theme	radiation	924:932	arg1	cycle					944:948	a long radiation treatment cycle	917:948	an impressive tumor imaging as well as a long radiation treatment cycle	878:948	The 125 I-labeled nanocomposites display an impressive tumor imaging as well as a long radiation treatment cycle.
33326188	4	24	theme	tyrosine	696:703	arg1	HA					728:729	HA	728:729	HA	728:729	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
33326188	4	24	theme	tyrosine	696:703	arg1	acid					722:725	tyrosine (Tyr)-hyaluronic acid	696:725	tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI)	696:754	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
33326188	0	25	theme	I	19:19	arg1	Co-Delivery					0:10	Co-Delivery	0:10	Co-Delivery of 131 I and Prima-1 by Self-Assembled CD44-Targeted Nanoparticles for Anaplastic Thyroid Carcinoma Theranostics.	0:124	Co-Delivery of 131 I and Prima-1 by Self-Assembled CD44-Targeted Nanoparticles for Anaplastic Thyroid Carcinoma Theranostics.
33326188	3	26	theme	CD44	589:592	arg1	expression					551:560	high expression	546:560	high expression of cluster determinant 44 (CD44)	546:593	In order to figure out a potential treatment, immuno-histochemical staining is performed in human ATC tissue species and high expression of cluster determinant 44 (CD44) is found.
33326188	0	27	theme	131	15:17	arg1	I					19:19	131 I	15:19	131 I	15:19	Co-Delivery of 131 I and Prima-1 by Self-Assembled CD44-Targeted Nanoparticles for Anaplastic Thyroid Carcinoma Theranostics.
33326188	3	28	theme	cluster	565:571	arg1	CD44					589:592	cluster determinant 44 (CD44)	565:593	cluster determinant 44 (CD44)	565:593	In order to figure out a potential treatment, immuno-histochemical staining is performed in human ATC tissue species and high expression of cluster determinant 44 (CD44) is found.
33326188	3	29	theme	high	546:549	arg1	expression					551:560	high expression	546:560	high expression of cluster determinant 44 (CD44)	546:593	In order to figure out a potential treatment, immuno-histochemical staining is performed in human ATC tissue species and high expression of cluster determinant 44 (CD44) is found.
33326188	0	30	theme	Prima-1	25:31	arg1	Co-Delivery					0:10	Co-Delivery	0:10	Co-Delivery of 131 I and Prima-1 by Self-Assembled CD44-Targeted Nanoparticles for Anaplastic Thyroid Carcinoma Theranostics.	0:124	Co-Delivery of 131 I and Prima-1 by Self-Assembled CD44-Targeted Nanoparticles for Anaplastic Thyroid Carcinoma Theranostics.
33326188	2	31	theme	lacking	371:377	arg1	targets					388:394	lacking suitable targets	371:394	lacking suitable targets	371:394	Nevertheless, such therapeutic strategy is clinically unfeasible on anaplastic thyroid carcinoma (ATC) patients, because of lacking suitable targets and resistance to radiation.
33326188	6	32	theme	mutants	1108:1114	arg1	reactivation					1084:1095	reactivation	1084:1095	reactivation of the p53 mutants	1084:1114	The 131 I-labeled nanoparticles show remarkable anti ATC-tumor effects in vitro and in vivo, due to radiosensitization of Prima-1 by reactivation of the p53 mutants.
33326188	2	33	from	unfeasible	301:310	arg1	patients					350:357	anaplastic thyroid carcinoma (ATC) patients	315:357	anaplastic thyroid carcinoma (ATC) patients	315:357	Nevertheless, such therapeutic strategy is clinically unfeasible on anaplastic thyroid carcinoma (ATC) patients, because of lacking suitable targets and resistance to radiation.
33326188	2	34	theme	therapeutic	266:276	arg1	strategy					278:285	such therapeutic strategy	261:285	such therapeutic strategy	261:285	Nevertheless, such therapeutic strategy is clinically unfeasible on anaplastic thyroid carcinoma (ATC) patients, because of lacking suitable targets and resistance to radiation.
33326188	0	35	theme	Self-Assembled	36:49	arg1	Nanoparticles					65:77	Self-Assembled CD44-Targeted Nanoparticles	36:77	Self-Assembled CD44-Targeted Nanoparticles	36:77	Co-Delivery of 131 I and Prima-1 by Self-Assembled CD44-Targeted Nanoparticles for Anaplastic Thyroid Carcinoma Theranostics.
33326188	2	36	theme	such	261:264	arg1	strategy					278:285	such therapeutic strategy	261:285	such therapeutic strategy	261:285	Nevertheless, such therapeutic strategy is clinically unfeasible on anaplastic thyroid carcinoma (ATC) patients, because of lacking suitable targets and resistance to radiation.
33326188	1	37	theme	New	126:128	arg1	systems					173:179	New radionuclide-labeled targeting nanocarrier systems	126:179	New radionuclide-labeled targeting nanocarrier systems	126:179	New radionuclide-labeled targeting nanocarrier systems have generated new opportunities for tumor treatment and imaging.
33326188	4	38	theme	CD44-targeted	618:630	arg1	system					641:646	a CD44-targeted delivery system	616:646	a CD44-targeted delivery system	616:646	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
33326188	6	39	theme	due	1044:1046	arg1	effects					1014:1020	remarkable anti ATC-tumor effects	988:1020	remarkable anti ATC-tumor effects	988:1020	The 131 I-labeled nanoparticles show remarkable anti ATC-tumor effects in vitro and in vivo, due to radiosensitization of Prima-1 by reactivation of the p53 mutants.
33326188	1	40	theme	radionuclide-labeled	130:149	arg1	systems					173:179	New radionuclide-labeled targeting nanocarrier systems	126:179	New radionuclide-labeled targeting nanocarrier systems	126:179	New radionuclide-labeled targeting nanocarrier systems have generated new opportunities for tumor treatment and imaging.
33326188	4	41	theme	-polyethyleneimine	731:748	arg1	self-assembly					679:691	self-assembly	679:691	self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1	679:834	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
33326188	4	42	theme	p53	799:801	arg1	mutant					803:808	a p53 mutant	797:808	a p53 mutant	797:808	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
33326188	1	43	theme	targeting	151:159	arg1	systems					173:179	New radionuclide-labeled targeting nanocarrier systems	126:179	New radionuclide-labeled targeting nanocarrier systems	126:179	New radionuclide-labeled targeting nanocarrier systems have generated new opportunities for tumor treatment and imaging.
33326188	5	44	theme	treatment	934:942	arg1	cycle					944:948	a long radiation treatment cycle	917:948	an impressive tumor imaging as well as a long radiation treatment cycle	878:948	The 125 I-labeled nanocomposites display an impressive tumor imaging as well as a long radiation treatment cycle.
33326188	4	45	theme	delivery	632:639	arg1	system					641:646	a CD44-targeted delivery system	616:646	a CD44-targeted delivery system	616:646	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
33326188	3	46	theme	determinant	573:583	arg1	CD44					589:592	cluster determinant 44 (CD44)	565:593	cluster determinant 44 (CD44)	565:593	In order to figure out a potential treatment, immuno-histochemical staining is performed in human ATC tissue species and high expression of cluster determinant 44 (CD44) is found.
33326188	4	47	theme	131/125	778:784	arg1	I					786:786	131/125 I	778:786	131/125 I	778:786	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
33326188	1	48	theme	nanocarrier	161:171	arg1	systems					173:179	New radionuclide-labeled targeting nanocarrier systems	126:179	New radionuclide-labeled targeting nanocarrier systems	126:179	New radionuclide-labeled targeting nanocarrier systems have generated new opportunities for tumor treatment and imaging.
33326188	3	49	theme	human	517:521	arg1	species					534:540	human ATC tissue species	517:540	human ATC tissue species	517:540	In order to figure out a potential treatment, immuno-histochemical staining is performed in human ATC tissue species and high expression of cluster determinant 44 (CD44) is found.
33326188	5	50	theme	I-labeled	845:853	arg1	nanocomposites					855:868	The 125 I-labeled nanocomposites	837:868	The 125 I-labeled nanocomposites	837:868	The 125 I-labeled nanocomposites display an impressive tumor imaging as well as a long radiation treatment cycle.
33326188	0	51	theme	CD44-Targeted	51:63	arg1	Nanoparticles					65:77	Self-Assembled CD44-Targeted Nanoparticles	36:77	Self-Assembled CD44-Targeted Nanoparticles	36:77	Co-Delivery of 131 I and Prima-1 by Self-Assembled CD44-Targeted Nanoparticles for Anaplastic Thyroid Carcinoma Theranostics.
33326188	6	52	theme	ATC-tumor	1004:1012	arg1	effects					1014:1020	remarkable anti ATC-tumor effects	988:1020	remarkable anti ATC-tumor effects	988:1020	The 131 I-labeled nanoparticles show remarkable anti ATC-tumor effects in vitro and in vivo, due to radiosensitization of Prima-1 by reactivation of the p53 mutants.
33326188	4	53	theme	Tyr	706:708	arg1	HA					728:729	HA	728:729	HA	728:729	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
33326188	4	53	theme	Tyr	706:708	arg1	acid					722:725	tyrosine (Tyr)-hyaluronic acid	696:725	tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI)	696:754	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
33326188	4	54	dep	I	786:786	arg1	mutant					803:808	a p53 mutant	797:808	a p53 mutant	797:808	Therefore, a CD44-targeted delivery system is designed and constructed by self-assembly of tyrosine (Tyr)-hyaluronic acid (HA)-polyethyleneimine (PEI), which can radiolabel 131/125 I and load a p53 mutant restoring regent, Prima-1.
32991898	8	0	with	AgNPs	1473:1477	arg1	AgNPs					1507:1511	AgNPs	1507:1511	AgNPs	1507:1511	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	4	1	dep	non-toxic	537:545	arg1	biodegradable					548:560	biodegradable	548:560	biodegradable	548:560	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	4	2	theme	ammonium	726:733	arg1	APS					748:750	APS	748:750	APS	748:750	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	4	2	theme	ammonium	726:733	arg1	persulphate					735:745	ammonium persulphate	726:745	ammonium persulphate (APS)	726:751	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	3	3	theme	anti-inflammatory	497:513	arg1	agents					515:520	anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	451:520	anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	451:520	This prompted us to search for non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents.
32991898	3	3	theme	anti-inflammatory	497:513	arg1	materials					421:429	non-traditional materials	405:429	non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	405:520	This prompted us to search for non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents.
32991898	8	4	contain	has	1366:1368	arg1	2-aminothiophenol					1326:1342	2-aminothiophenol	1326:1342	2-aminothiophenol	1326:1342	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	8	4	contain	has	1366:1368	arg1	chitosan-gr-p2-ATH					1346:1363	chitosan-gr-p2-ATH	1346:1363	chitosan-gr-p2-ATH	1346:1363	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	8	4	contain	has	1366:1368	arg1	chitosan-gr-poly					1308:1323	chitosan-gr-poly	1308:1323	chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH)	1308:1364	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	8	4	contain	has	1366:1368	arg2	effects					1415:1421	the most potent anti-oxidant and anti-cancer effects	1370:1421	the most potent anti-oxidant and anti-cancer effects against HepG2	1370:1435	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	4	5	theme	biological	588:597	arg1	activity					599:606	powerful biological activity	579:606	powerful biological activity	579:606	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	5	6	theme	polymeric	801:809	arg1	samples					811:817	The prepared polymeric samples	788:817	The prepared polymeric samples	788:817	The prepared polymeric samples were assembled on silver nanoparticles (AgNPs).
32991898	2	7	theme	other	350:354	arg1	damage					339:344	oxidative damage	329:344	oxidative damage	329:344	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	7	theme	other	350:354	arg1	causes					356:361	other causes	350:361	other causes for death	350:371	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	7	theme	other	350:354	arg1	malfunction					268:278	Immune system malfunction	254:278	Immune system malfunction	254:278	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	7	theme	other	350:354	arg1	diseases					294:301	inflammatory diseases	281:301	inflammatory diseases	281:301	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	7	theme	other	350:354	arg1	infection					314:322	microbial infection	304:322	microbial infection	304:322	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	6	8	theme	prepared	871:878	arg1	nano-composites					900:914	The prepared polymeric structure nano-composites	867:914	The prepared polymeric structure nano-composites	867:914	The prepared polymeric structure nano-composites were verified by infrared, ultraviolet-visible spectroscopy, X-ray diffraction, thermogravimetric analysis scanning electron microscopy and transmission electron microscopy.
32991898	4	9	theme	powerful	579:586	arg1	activity					599:606	powerful biological activity	579:606	powerful biological activity	579:606	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	6	10	theme	infrared	933:940	arg1	spectroscopy					963:974	infrared, ultraviolet-visible spectroscopy	933:974	infrared, ultraviolet-visible spectroscopy	933:974	The prepared polymeric structure nano-composites were verified by infrared, ultraviolet-visible spectroscopy, X-ray diffraction, thermogravimetric analysis scanning electron microscopy and transmission electron microscopy.
32991898	8	11	theme	p2-ATH	1461:1466	arg1	p2-ATH					1461:1466	p2-ATH	1461:1466	p2-ATH	1461:1466	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	8	11	theme	p2-ATH	1461:1466	arg1	composites					1447:1456	the composites	1443:1456	the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs	1443:1511	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	8	12	with	chitosan-gr-p2-ATH	1483:1500	arg1	AgNPs					1507:1511	AgNPs	1507:1511	AgNPs	1507:1511	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	2	13	theme	inflammatory	281:292	arg1	damage					339:344	oxidative damage	329:344	oxidative damage	329:344	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	13	theme	inflammatory	281:292	arg1	causes					356:361	other causes	350:361	other causes for death	350:371	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	13	theme	inflammatory	281:292	arg1	malfunction					268:278	Immune system malfunction	254:278	Immune system malfunction	254:278	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	13	theme	inflammatory	281:292	arg1	diseases					294:301	inflammatory diseases	281:301	inflammatory diseases	281:301	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	13	theme	inflammatory	281:292	arg1	infection					314:322	microbial infection	304:322	microbial infection	304:322	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	4	14	from	temperature	775:785	arg1	oxidant					759:765	an oxidant	756:765	an oxidant at room temperature	756:785	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	4	14	from	temperature	775:785	arg1	copolymerization					694:709	aqueous chemical oxidative copolymerization	667:709	aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS)	667:751	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	1	15	theme	uncontrolled	165:176	arg1	division					178:185	the uncontrolled division	161:185	the uncontrolled division of the cells	161:198	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	4	16	from	copolymerization	694:709	arg1	presence					714:721	presence	714:721	presence of ammonium persulphate (APS)	714:751	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	8	17	theme	anti-cancer	1403:1413	arg1	effects					1415:1421	the most potent anti-oxidant and anti-cancer effects	1370:1421	the most potent anti-oxidant and anti-cancer effects against HepG2	1370:1435	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	4	18	theme	chemical	675:682	arg1	oxidant					759:765	an oxidant	756:765	an oxidant at room temperature	756:785	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	4	18	theme	chemical	675:682	arg1	copolymerization					694:709	aqueous chemical oxidative copolymerization	667:709	aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS)	667:751	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	4	19	with	biopolymer	563:572	arg1	activity					599:606	powerful biological activity	579:606	powerful biological activity	579:606	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	6	20	theme	electron	1069:1076	arg1	microscopy					1078:1087	transmission electron microscopy	1056:1087	transmission electron microscopy	1056:1087	The prepared polymeric structure nano-composites were verified by infrared, ultraviolet-visible spectroscopy, X-ray diffraction, thermogravimetric analysis scanning electron microscopy and transmission electron microscopy.
32991898	8	21	theme	obtained	1282:1289	arg1	data					1291:1294	The obtained data	1278:1294	The obtained data	1278:1294	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	4	22	theme	aqueous	667:673	arg1	oxidant					759:765	an oxidant	756:765	an oxidant at room temperature	756:785	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	4	22	theme	aqueous	667:673	arg1	copolymerization					694:709	aqueous chemical oxidative copolymerization	667:709	aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS)	667:751	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	8	23	theme	anti-inflammatory	1534:1550	arg1	properties					1552:1561	the most potent anti-inflammatory properties	1518:1561	the most potent anti-inflammatory properties	1518:1561	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	1	24	theme	cells	194:198	arg1	division					178:185	the uncontrolled division	161:185	the uncontrolled division of the cells	161:198	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	7	25	with	samples	1113:1119	arg1	AgNPs					1147:1151	AgNPs	1147:1151	AgNPs	1147:1151	The prepared polymeric samples and their composites with AgNPs were screened for their biological activities as anti-cancer properties, anti-microbial, anti-oxidant and anti-inflammatory.
32991898	6	26	theme	electron	1032:1039	arg1	microscopy					1041:1050	thermogravimetric analysis scanning electron microscopy	996:1050	thermogravimetric analysis scanning electron microscopy	996:1050	The prepared polymeric structure nano-composites were verified by infrared, ultraviolet-visible spectroscopy, X-ray diffraction, thermogravimetric analysis scanning electron microscopy and transmission electron microscopy.
32991898	6	27	dep	infrared	933:940	arg1	ultraviolet-visible					943:961	ultraviolet-visible	943:961	ultraviolet-visible	943:961	The prepared polymeric structure nano-composites were verified by infrared, ultraviolet-visible spectroscopy, X-ray diffraction, thermogravimetric analysis scanning electron microscopy and transmission electron microscopy.
32991898	3	28	used	used	443:446	arg2	materials					421:429	non-traditional materials	405:429	non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	405:520	This prompted us to search for non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents.
32991898	3	28	used	used	443:446	arg2	agents					515:520	anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	451:520	anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	451:520	This prompted us to search for non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents.
32991898	4	29	theme	oxidative	684:692	arg1	oxidant					759:765	an oxidant	756:765	an oxidant at room temperature	756:785	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	4	29	theme	oxidative	684:692	arg1	copolymerization					694:709	aqueous chemical oxidative copolymerization	667:709	aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS)	667:751	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	0	30	theme	polymeric	22:30	arg1	nanocomposites					32:45	facile polymeric nanocomposites	15:45	facile polymeric nanocomposites	15:45	Fabrication of facile polymeric nanocomposites based on chitosan-gr-P2-aminothiophenol for biomedical applications.
32991898	6	31	theme	scanning	1023:1030	arg1	microscopy					1041:1050	thermogravimetric analysis scanning electron microscopy	996:1050	thermogravimetric analysis scanning electron microscopy	996:1050	The prepared polymeric structure nano-composites were verified by infrared, ultraviolet-visible spectroscopy, X-ray diffraction, thermogravimetric analysis scanning electron microscopy and transmission electron microscopy.
32991898	7	32	theme	anti-cancer	1202:1212	arg1	properties					1214:1223	anti-cancer properties	1202:1223	anti-cancer properties	1202:1223	The prepared polymeric samples and their composites with AgNPs were screened for their biological activities as anti-cancer properties, anti-microbial, anti-oxidant and anti-inflammatory.
32991898	2	33	theme	microbial	304:312	arg1	damage					339:344	oxidative damage	329:344	oxidative damage	329:344	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	33	theme	microbial	304:312	arg1	causes					356:361	other causes	350:361	other causes for death	350:371	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	33	theme	microbial	304:312	arg1	malfunction					268:278	Immune system malfunction	254:278	Immune system malfunction	254:278	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	33	theme	microbial	304:312	arg1	diseases					294:301	inflammatory diseases	281:301	inflammatory diseases	281:301	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	33	theme	microbial	304:312	arg1	infection					314:322	microbial infection	304:322	microbial infection	304:322	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	3	34	theme	anti-cancer	451:461	arg1	agents					515:520	anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	451:520	anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	451:520	This prompted us to search for non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents.
32991898	3	34	theme	anti-cancer	451:461	arg1	materials					421:429	non-traditional materials	405:429	non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	405:520	This prompted us to search for non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents.
32991898	0	35	theme	facile	15:20	arg1	nanocomposites					32:45	facile polymeric nanocomposites	15:45	facile polymeric nanocomposites	15:45	Fabrication of facile polymeric nanocomposites based on chitosan-gr-P2-aminothiophenol for biomedical applications.
32991898	6	36	theme	analysis	1014:1021	arg1	microscopy					1041:1050	thermogravimetric analysis scanning electron microscopy	996:1050	thermogravimetric analysis scanning electron microscopy	996:1050	The prepared polymeric structure nano-composites were verified by infrared, ultraviolet-visible spectroscopy, X-ray diffraction, thermogravimetric analysis scanning electron microscopy and transmission electron microscopy.
32991898	6	37	theme	structure	890:898	arg1	nano-composites					900:914	The prepared polymeric structure nano-composites	867:914	The prepared polymeric structure nano-composites	867:914	The prepared polymeric structure nano-composites were verified by infrared, ultraviolet-visible spectroscopy, X-ray diffraction, thermogravimetric analysis scanning electron microscopy and transmission electron microscopy.
32991898	1	38	theme	abnormal	129:136	arg1	growth					138:143	an abnormal growth	126:143	an abnormal growth of cells	126:152	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	1	38	theme	abnormal	129:136	arg1	Cancer					116:121	Cancer	116:121	Cancer	116:121	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	7	39	theme	anti-oxidant	1242:1253	arg1	properties					1214:1223	anti-cancer properties	1202:1223	anti-cancer properties	1202:1223	The prepared polymeric samples and their composites with AgNPs were screened for their biological activities as anti-cancer properties, anti-microbial, anti-oxidant and anti-inflammatory.
32991898	5	40	theme	prepared	792:799	arg1	samples					811:817	The prepared polymeric samples	788:817	The prepared polymeric samples	788:817	The prepared polymeric samples were assembled on silver nanoparticles (AgNPs).
32991898	6	41	theme	thermogravimetric	996:1012	arg1	microscopy					1041:1050	thermogravimetric analysis scanning electron microscopy	996:1050	thermogravimetric analysis scanning electron microscopy	996:1050	The prepared polymeric structure nano-composites were verified by infrared, ultraviolet-visible spectroscopy, X-ray diffraction, thermogravimetric analysis scanning electron microscopy and transmission electron microscopy.
32991898	6	42	theme	polymeric	880:888	arg1	nano-composites					900:914	The prepared polymeric structure nano-composites	867:914	The prepared polymeric structure nano-composites	867:914	The prepared polymeric structure nano-composites were verified by infrared, ultraviolet-visible spectroscopy, X-ray diffraction, thermogravimetric analysis scanning electron microscopy and transmission electron microscopy.
32991898	8	43	theme	anti-oxidant	1386:1397	arg1	effects					1415:1421	the most potent anti-oxidant and anti-cancer effects	1370:1421	the most potent anti-oxidant and anti-cancer effects against HepG2	1370:1435	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	0	44	theme	nanocomposites	32:45	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of facile polymeric nanocomposites	0:45	Fabrication of facile polymeric nanocomposites based on chitosan-gr-P2-aminothiophenol for biomedical applications.
32991898	3	45	theme	non-traditional	405:419	arg1	agents					515:520	anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	451:520	anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	451:520	This prompted us to search for non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents.
32991898	3	45	theme	non-traditional	405:419	arg1	materials					421:429	non-traditional materials	405:429	non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	405:520	This prompted us to search for non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents.
32991898	4	46	theme	room	770:773	arg1	temperature					775:785	room temperature	770:785	room temperature	770:785	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	5	47	theme	silver	837:842	arg1	AgNPs					859:863	AgNPs	859:863	AgNPs	859:863	The prepared polymeric samples were assembled on silver nanoparticles (AgNPs).
32991898	5	47	theme	silver	837:842	arg1	nanoparticles					844:856	silver nanoparticles	837:856	silver nanoparticles (AgNPs)	837:864	The prepared polymeric samples were assembled on silver nanoparticles (AgNPs).
32991898	1	48	theme	second	214:219	arg1	cause					229:233	the second leading cause	210:233	the second leading cause of death	210:242	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	1	48	theme	second	214:219	arg1	it					204:205	it	204:205	it	204:205	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	8	49	contain	have	1513:1516	arg2	properties					1552:1561	the most potent anti-inflammatory properties	1518:1561	the most potent anti-inflammatory properties	1518:1561	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	8	49	contain	have	1513:1516	arg1	p2-ATH					1461:1466	p2-ATH	1461:1466	p2-ATH	1461:1466	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	8	49	contain	have	1513:1516	arg1	composites					1447:1456	the composites	1443:1456	the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs	1443:1511	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	8	50	theme	potent	1527:1532	arg1	properties					1552:1561	the most potent anti-inflammatory properties	1518:1561	the most potent anti-inflammatory properties	1518:1561	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	7	51	theme	prepared	1094:1101	arg1	samples					1113:1119	The prepared polymeric samples	1090:1119	The prepared polymeric samples	1090:1119	The prepared polymeric samples and their composites with AgNPs were screened for their biological activities as anti-cancer properties, anti-microbial, anti-oxidant and anti-inflammatory.
32991898	3	52	theme	anti-oxidant	480:491	arg1	agents					515:520	anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	451:520	anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	451:520	This prompted us to search for non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents.
32991898	3	52	theme	anti-oxidant	480:491	arg1	materials					421:429	non-traditional materials	405:429	non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	405:520	This prompted us to search for non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents.
32991898	7	53	theme	anti-microbial	1226:1239	arg1	properties					1214:1223	anti-cancer properties	1202:1223	anti-cancer properties	1202:1223	The prepared polymeric samples and their composites with AgNPs were screened for their biological activities as anti-cancer properties, anti-microbial, anti-oxidant and anti-inflammatory.
32991898	6	54	theme	X-ray	977:981	arg1	diffraction					983:993	X-ray diffraction	977:993	X-ray diffraction	977:993	The prepared polymeric structure nano-composites were verified by infrared, ultraviolet-visible spectroscopy, X-ray diffraction, thermogravimetric analysis scanning electron microscopy and transmission electron microscopy.
32991898	3	55	theme	anti-microbial	464:477	arg1	agents					515:520	anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	451:520	anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	451:520	This prompted us to search for non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents.
32991898	3	55	theme	anti-microbial	464:477	arg1	materials					421:429	non-traditional materials	405:429	non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents	405:520	This prompted us to search for non-traditional materials that can be used as anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory agents.
32991898	8	56	with	composites	1447:1456	arg1	chitosan-gr-p2-ATH					1483:1500	chitosan-gr-p2-ATH	1483:1500	chitosan-gr-p2-ATH	1483:1500	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	8	56	with	composites	1447:1456	arg1	AgNPs					1473:1477	AgNPs	1473:1477	AgNPs	1473:1477	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	7	57	theme	biological	1177:1186	arg1	activities					1188:1197	their biological activities	1171:1197	their biological activities as anti-cancer properties, anti-microbial, anti-oxidant and anti-inflammatory	1171:1275	The prepared polymeric samples and their composites with AgNPs were screened for their biological activities as anti-cancer properties, anti-microbial, anti-oxidant and anti-inflammatory.
32991898	4	58	theme	persulphate	735:745	arg1	presence					714:721	presence	714:721	presence of ammonium persulphate (APS)	714:751	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	4	59	theme	non-toxic	537:545	arg1	biopolymer					563:572	a non-toxic, biodegradable, biopolymer	535:572	biopolymer	563:572	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	7	60	theme	polymeric	1103:1111	arg1	samples					1113:1119	The prepared polymeric samples	1090:1119	The prepared polymeric samples	1090:1119	The prepared polymeric samples and their composites with AgNPs were screened for their biological activities as anti-cancer properties, anti-microbial, anti-oxidant and anti-inflammatory.
32991898	2	61	theme	system	261:266	arg1	damage					339:344	oxidative damage	329:344	oxidative damage	329:344	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	61	theme	system	261:266	arg1	causes					356:361	other causes	350:361	other causes for death	350:371	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	61	theme	system	261:266	arg1	malfunction					268:278	Immune system malfunction	254:278	Immune system malfunction	254:278	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	61	theme	system	261:266	arg1	diseases					294:301	inflammatory diseases	281:301	inflammatory diseases	281:301	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	61	theme	system	261:266	arg1	infection					314:322	microbial infection	304:322	microbial infection	304:322	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	1	62	theme	cells	148:152	arg1	growth					138:143	an abnormal growth	126:143	an abnormal growth of cells	126:152	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	1	62	theme	cells	148:152	arg1	it					204:205	it	204:205	it	204:205	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	1	62	theme	cells	148:152	arg1	cause					229:233	the second leading cause	210:233	the second leading cause of death	210:242	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	1	62	theme	cells	148:152	arg1	Cancer					116:121	Cancer	116:121	Cancer	116:121	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	1	63	theme	leading	221:227	arg1	cause					229:233	the second leading cause	210:233	the second leading cause of death	210:242	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	1	63	theme	leading	221:227	arg1	it					204:205	it	204:205	it	204:205	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	2	64	theme	Immune	254:259	arg1	damage					339:344	oxidative damage	329:344	oxidative damage	329:344	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	64	theme	Immune	254:259	arg1	causes					356:361	other causes	350:361	other causes for death	350:371	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	64	theme	Immune	254:259	arg1	malfunction					268:278	Immune system malfunction	254:278	Immune system malfunction	254:278	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	64	theme	Immune	254:259	arg1	diseases					294:301	inflammatory diseases	281:301	inflammatory diseases	281:301	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	64	theme	Immune	254:259	arg1	infection					314:322	microbial infection	304:322	microbial infection	304:322	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	65	theme	oxidative	329:337	arg1	damage					339:344	oxidative damage	329:344	oxidative damage	329:344	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	65	theme	oxidative	329:337	arg1	causes					356:361	other causes	350:361	other causes for death	350:371	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	65	theme	oxidative	329:337	arg1	malfunction					268:278	Immune system malfunction	254:278	Immune system malfunction	254:278	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	65	theme	oxidative	329:337	arg1	diseases					294:301	inflammatory diseases	281:301	inflammatory diseases	281:301	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	2	65	theme	oxidative	329:337	arg1	infection					314:322	microbial infection	304:322	microbial infection	304:322	Immune system malfunction, inflammatory diseases, microbial infection, and oxidative damage are other causes for death.
32991898	0	66	theme	biomedical	91:100	arg1	applications					102:113	biomedical applications	91:113	biomedical applications	91:113	Fabrication of facile polymeric nanocomposites based on chitosan-gr-P2-aminothiophenol for biomedical applications.
32991898	8	67	theme	potent	1379:1384	arg1	effects					1415:1421	the most potent anti-oxidant and anti-cancer effects	1370:1421	the most potent anti-oxidant and anti-cancer effects against HepG2	1370:1435	The obtained data reveal that chitosan-gr-poly (2-aminothiophenol) (chitosan-gr-p2-ATH) has the most potent anti-oxidant and anti-cancer effects against HepG2 while the composites of p2-ATH with AgNPs and chitosan-gr-p2-ATH with AgNPs have the most potent anti-inflammatory properties.
32991898	7	68	with	composites	1131:1140	arg1	AgNPs					1147:1151	AgNPs	1147:1151	AgNPs	1147:1151	The prepared polymeric samples and their composites with AgNPs were screened for their biological activities as anti-cancer properties, anti-microbial, anti-oxidant and anti-inflammatory.
32991898	6	69	theme	transmission	1056:1067	arg1	microscopy					1078:1087	transmission electron microscopy	1056:1087	transmission electron microscopy	1056:1087	The prepared polymeric structure nano-composites were verified by infrared, ultraviolet-visible spectroscopy, X-ray diffraction, thermogravimetric analysis scanning electron microscopy and transmission electron microscopy.
32991898	4	70	theme	acidified	625:633	arg1	2-ATH					654:658	2-ATH	654:658	2-ATH	654:658	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	4	70	theme	acidified	625:633	arg1	2-aminothiophenol					635:651	acidified 2-aminothiophenol	625:651	acidified 2-aminothiophenol (2-ATH)	625:659	Chitosan as a non-toxic, biodegradable, biopolymer with powerful biological activity was grafted with acidified 2-aminothiophenol (2-ATH) using aqueous chemical oxidative copolymerization in presence of ammonium persulphate (APS) as an oxidant at room temperature.
32991898	7	71	theme	anti-inflammatory	1259:1275	arg1	properties					1214:1223	anti-cancer properties	1202:1223	anti-cancer properties	1202:1223	The prepared polymeric samples and their composites with AgNPs were screened for their biological activities as anti-cancer properties, anti-microbial, anti-oxidant and anti-inflammatory.
32991898	1	72	theme	death	238:242	arg1	growth					138:143	an abnormal growth	126:143	an abnormal growth of cells	126:152	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	1	72	theme	death	238:242	arg1	it					204:205	it	204:205	it	204:205	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	1	72	theme	death	238:242	arg1	cause					229:233	the second leading cause	210:233	the second leading cause of death	210:242	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32991898	1	72	theme	death	238:242	arg1	Cancer					116:121	Cancer	116:121	Cancer	116:121	Cancer is an abnormal growth of cells due to the uncontrolled division of the cells and it is the second leading cause of death globally.
32147344	0	0	theme	potential	78:86	arg1	candidate					88:96	a novel potential candidate	70:96	a novel potential candidate for tissue engineering	70:119	Electroactive poly (p-phenylene sulfide)/r-graphene oxide/chitosan as a novel potential candidate for tissue engineering.
32147344	1	1	theme	engineering	162:172	arg1	purpose					174:180	tissue engineering purpose	155:180	tissue engineering purpose	155:180	Designing novel biomaterials for tissue engineering purpose is an obvious necessary considering ever increasing need for appropriate biocompatibility and properties to achieve the maximum regeneration.
32147344	0	2	theme	novel	72:76	arg1	candidate					88:96	a novel potential candidate	70:96	a novel potential candidate for tissue engineering	70:119	Electroactive poly (p-phenylene sulfide)/r-graphene oxide/chitosan as a novel potential candidate for tissue engineering.
32147344	3	3	dep	Fourier	561:567	arg1	transform					569:577	transform	569:577	transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests	569:702	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial.
32147344	6	4	theme	swelling	1059:1066	arg1	ratio					1068:1072	Chitosan hydrogel swelling ratio	1041:1072	Chitosan hydrogel swelling ratio	1041:1072	Chitosan hydrogel swelling ratio was declined from 800 to 200% by PPS/rGO addition; likewise, water vapor transition rate (WVTR) was dropped.
32147344	4	5	theme	Thermal	767:773	arg1	behavior					775:782	Thermal behavior	767:782	Thermal behavior of the PPS/rGO composite	767:807	Thermal behavior of the PPS/rGO composite was evaluated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA).
32147344	6	6	theme	PPS/rGO	1107:1113	arg1	addition					1115:1122	PPS/rGO addition	1107:1122	PPS/rGO addition	1107:1122	Chitosan hydrogel swelling ratio was declined from 800 to 200% by PPS/rGO addition; likewise, water vapor transition rate (WVTR) was dropped.
32147344	6	7	theme	transition	1147:1156	arg1	WVTR					1164:1167	WVTR	1164:1167	WVTR	1164:1167	Chitosan hydrogel swelling ratio was declined from 800 to 200% by PPS/rGO addition; likewise, water vapor transition rate (WVTR) was dropped.
32147344	6	7	theme	transition	1147:1156	arg1	rate					1158:1161	water vapor transition rate	1135:1161	water vapor transition rate (WVTR)	1135:1168	Chitosan hydrogel swelling ratio was declined from 800 to 200% by PPS/rGO addition; likewise, water vapor transition rate (WVTR) was dropped.
32147344	5	8	theme	10	937:938	arg1	composition					918:928	The PPS/rGO composition	906:928	The PPS/rGO composition of 90: 10 (w/w)	906:944	The PPS/rGO composition of 90: 10 (w/w) was selected because of having the highest biocompatibility and utilized in chitosan hydrogel.
32147344	7	9	theme	cell	1213:1216	arg1	attachment					1218:1227	cell attachment	1213:1227	cell attachment	1213:1227	A proper biocompatibility and cell attachment was confirmed, where porosity of ca. 80% appeared promising for tissue engineering uses.
32147344	4	10	theme	differential	826:837	arg1	DSC					861:863	DSC	861:863	DSC	861:863	Thermal behavior of the PPS/rGO composite was evaluated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA).
32147344	4	10	theme	differential	826:837	arg1	calorimetry					848:858	differential scanning calorimetry	826:858	differential scanning calorimetry (DSC)	826:864	Thermal behavior of the PPS/rGO composite was evaluated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA).
32147344	6	11	theme	Chitosan	1041:1048	arg1	ratio					1068:1072	Chitosan hydrogel swelling ratio	1041:1072	Chitosan hydrogel swelling ratio	1041:1072	Chitosan hydrogel swelling ratio was declined from 800 to 200% by PPS/rGO addition; likewise, water vapor transition rate (WVTR) was dropped.
32147344	7	12	theme	%	1268:1268	arg1	porosity					1250:1257	porosity	1250:1257	porosity of ca. 80%	1250:1268	A proper biocompatibility and cell attachment was confirmed, where porosity of ca. 80% appeared promising for tissue engineering uses.
32147344	3	13	dep	transform	569:577	arg1	infrared					579:586	infrared	579:586	transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests	569:702	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial.
32147344	0	14	theme	tissue	102:107	arg1	engineering					109:119	tissue engineering	102:119	tissue engineering	102:119	Electroactive poly (p-phenylene sulfide)/r-graphene oxide/chitosan as a novel potential candidate for tissue engineering.
32147344	6	15	dep	200	1099:1101	arg1	to					1096:1097	to	1096:1097	to	1096:1097	Chitosan hydrogel swelling ratio was declined from 800 to 200% by PPS/rGO addition; likewise, water vapor transition rate (WVTR) was dropped.
32147344	0	16	theme	poly	14:17	arg1	/r-graphene					40:50	Electroactive poly (p-phenylene sulfide)/r-graphene	0:50	Electroactive poly (p-phenylene sulfide)/r-graphene	0:50	Electroactive poly (p-phenylene sulfide)/r-graphene oxide/chitosan as a novel potential candidate for tissue engineering.
32147344	3	17	theme	compression	686:696	arg1	tests					698:702	compression tests	686:702	compression tests	686:702	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial.
32147344	7	18	theme	proper	1185:1190	arg1	biocompatibility					1192:1207	A proper biocompatibility	1183:1207	A proper biocompatibility	1183:1207	A proper biocompatibility and cell attachment was confirmed, where porosity of ca. 80% appeared promising for tissue engineering uses.
32147344	5	19	theme	PPS/rGO	910:916	arg1	composition					918:928	The PPS/rGO composition	906:928	The PPS/rGO composition of 90: 10 (w/w)	906:944	The PPS/rGO composition of 90: 10 (w/w) was selected because of having the highest biocompatibility and utilized in chitosan hydrogel.
32147344	0	20	theme	Electroactive	0:12	arg1	/r-graphene					40:50	Electroactive poly (p-phenylene sulfide)/r-graphene	0:50	Electroactive poly (p-phenylene sulfide)/r-graphene	0:50	Electroactive poly (p-phenylene sulfide)/r-graphene oxide/chitosan as a novel potential candidate for tissue engineering.
32147344	1	21	theme	maximum	302:308	arg1	regeneration					310:321	the maximum regeneration	298:321	the maximum regeneration	298:321	Designing novel biomaterials for tissue engineering purpose is an obvious necessary considering ever increasing need for appropriate biocompatibility and properties to achieve the maximum regeneration.
32147344	4	22	theme	scanning	839:846	arg1	DSC					861:863	DSC	861:863	DSC	861:863	Thermal behavior of the PPS/rGO composite was evaluated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA).
32147344	4	22	theme	scanning	839:846	arg1	calorimetry					848:858	differential scanning calorimetry	826:858	differential scanning calorimetry (DSC)	826:864	Thermal behavior of the PPS/rGO composite was evaluated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA).
32147344	2	23	theme	phenylene	383:391	arg1	poly					377:380	poly	377:380	poly (phenylene sulfide) (PPS)	377:406	In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially.
32147344	2	23	theme	phenylene	383:391	arg1	sulfide					393:399	phenylene sulfide	383:399	phenylene sulfide	383:399	In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially.
32147344	0	24	theme	p-phenylene	20:30	arg1	/r-graphene					40:50	Electroactive poly (p-phenylene sulfide)/r-graphene	0:50	Electroactive poly (p-phenylene sulfide)/r-graphene	0:50	Electroactive poly (p-phenylene sulfide)/r-graphene oxide/chitosan as a novel potential candidate for tissue engineering.
32147344	5	25	used	utilized	1010:1017	arg2	composition					918:928	The PPS/rGO composition	906:928	The PPS/rGO composition of 90: 10 (w/w)	906:944	The PPS/rGO composition of 90: 10 (w/w) was selected because of having the highest biocompatibility and utilized in chitosan hydrogel.
32147344	2	26	theme	wound	533:537	arg1	performance					516:526	its performance	512:526	its performance	512:526	In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially.
32147344	2	26	theme	wound	533:537	arg1	dressing					539:546	a wound dressing	531:546	a wound dressing potentially	531:558	In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially.
32147344	7	27	dep	80	1266:1267	arg1	ca.					1262:1264	ca.	1262:1264	ca.	1262:1264	A proper biocompatibility and cell attachment was confirmed, where porosity of ca. 80% appeared promising for tissue engineering uses.
32147344	2	28	theme	reduced	412:418	arg1	rGO					436:438	rGO	436:438	rGO	436:438	In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially.
32147344	2	28	theme	reduced	412:418	arg1	oxide					429:433	reduced graphene oxide	412:433	reduced graphene oxide (rGO)	412:439	In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially.
32147344	2	29	theme	graphene	420:427	arg1	rGO					436:438	rGO	436:438	rGO	436:438	In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially.
32147344	2	29	theme	graphene	420:427	arg1	oxide					429:433	reduced graphene oxide	412:433	reduced graphene oxide (rGO)	412:439	In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially.
32147344	5	30	theme	chitosan	1022:1029	arg1	hydrogel					1031:1038	chitosan hydrogel	1022:1038	chitosan hydrogel	1022:1038	The PPS/rGO composition of 90: 10 (w/w) was selected because of having the highest biocompatibility and utilized in chitosan hydrogel.
32147344	6	31	theme	hydrogel	1050:1057	arg1	ratio					1068:1072	Chitosan hydrogel swelling ratio	1041:1072	Chitosan hydrogel swelling ratio	1041:1072	Chitosan hydrogel swelling ratio was declined from 800 to 200% by PPS/rGO addition; likewise, water vapor transition rate (WVTR) was dropped.
32147344	8	32	theme	PPS/rGO	1371:1377	arg1	appropriateness					1352:1366	the appropriateness	1348:1366	the appropriateness of PPS/rGO for tissue engineering uses	1348:1405	Overall, the result confirmed the appropriateness of PPS/rGO for tissue engineering uses.
32147344	4	33	theme	composite	799:807	arg1	behavior					775:782	Thermal behavior	767:782	Thermal behavior of the PPS/rGO composite	767:807	Thermal behavior of the PPS/rGO composite was evaluated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA).
32147344	1	34	theme	increasing	223:232	arg1	need					234:237	ever increasing need	218:237	ever increasing need for appropriate biocompatibility and properties to achieve the maximum regeneration	218:321	Designing novel biomaterials for tissue engineering purpose is an obvious necessary considering ever increasing need for appropriate biocompatibility and properties to achieve the maximum regeneration.
32147344	0	35	theme	sulfide	32:38	arg1	/r-graphene					40:50	Electroactive poly (p-phenylene sulfide)/r-graphene	0:50	Electroactive poly (p-phenylene sulfide)/r-graphene	0:50	Electroactive poly (p-phenylene sulfide)/r-graphene oxide/chitosan as a novel potential candidate for tissue engineering.
32147344	3	36	theme	biomaterial	754:764	arg1	suitability					729:739	suitability	729:739	suitability of composite biomaterial	729:764	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial.
32147344	3	37	theme	diffraction	615:625	arg1	XRD					641:643	XRD	641:643	XRD	641:643	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial.
32147344	3	37	theme	diffraction	615:625	arg1	spectrometry					627:638	X-ray diffraction spectrometry	609:638	X-ray diffraction spectrometry (XRD)	609:644	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial.
32147344	4	38	theme	PPS/rGO	791:797	arg1	composite					799:807	the PPS/rGO composite	787:807	the PPS/rGO composite	787:807	Thermal behavior of the PPS/rGO composite was evaluated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA).
32147344	8	39	dep	engineering	1390:1400	arg1	uses					1402:1405	uses	1402:1405	uses	1402:1405	Overall, the result confirmed the appropriateness of PPS/rGO for tissue engineering uses.
32147344	4	40	theme	gravimetric	878:888	arg1	analysis					890:897	thermal gravimetric analysis	870:897	thermal gravimetric analysis (TGA)	870:903	Thermal behavior of the PPS/rGO composite was evaluated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA).
32147344	4	40	theme	gravimetric	878:888	arg1	TGA					900:902	TGA	900:902	TGA	900:902	Thermal behavior of the PPS/rGO composite was evaluated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA).
32147344	8	41	theme	tissue	1383:1388	arg1	engineering					1390:1400	tissue engineering	1383:1400	tissue engineering uses	1383:1405	Overall, the result confirmed the appropriateness of PPS/rGO for tissue engineering uses.
32147344	7	42	theme	tissue	1293:1298	arg1	engineering					1300:1310	tissue engineering	1293:1310	tissue engineering uses	1293:1315	A proper biocompatibility and cell attachment was confirmed, where porosity of ca. 80% appeared promising for tissue engineering uses.
32147344	2	43	theme	biomaterial	356:366	arg1	type					348:351	a new type	342:351	a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO)	342:439	In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially.
32147344	4	44	theme	thermal	870:876	arg1	analysis					890:897	thermal gravimetric analysis	870:897	thermal gravimetric analysis (TGA)	870:903	Thermal behavior of the PPS/rGO composite was evaluated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA).
32147344	4	44	theme	thermal	870:876	arg1	TGA					900:902	TGA	900:902	TGA	900:902	Thermal behavior of the PPS/rGO composite was evaluated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA).
32147344	3	45	theme	scanning	647:654	arg1	SEM					677:679	SEM	677:679	SEM	677:679	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial.
32147344	3	45	theme	scanning	647:654	arg1	microscopy					665:674	scanning electron microscopy	647:674	scanning electron microscopy (SEM)	647:680	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial.
32147344	5	46	theme	highest	981:987	arg1	biocompatibility					989:1004	the highest biocompatibility	977:1004	the highest biocompatibility	977:1004	The PPS/rGO composition of 90: 10 (w/w) was selected because of having the highest biocompatibility and utilized in chitosan hydrogel.
32147344	3	47	theme	composite	744:752	arg1	biomaterial					754:764	composite biomaterial	744:764	composite biomaterial	744:764	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial.
32147344	3	48	theme	electron	656:663	arg1	SEM					677:679	SEM	677:679	SEM	677:679	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial.
32147344	3	48	theme	electron	656:663	arg1	microscopy					665:674	scanning electron microscopy	647:674	scanning electron microscopy (SEM)	647:680	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial.
32147344	1	49	theme	novel	132:136	arg1	biomaterials					138:149	novel biomaterials	132:149	novel biomaterials	132:149	Designing novel biomaterials for tissue engineering purpose is an obvious necessary considering ever increasing need for appropriate biocompatibility and properties to achieve the maximum regeneration.
32147344	3	50	theme	X-ray	609:613	arg1	XRD					641:643	XRD	641:643	XRD	641:643	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial.
32147344	3	50	theme	X-ray	609:613	arg1	spectrometry					627:638	X-ray diffraction spectrometry	609:638	X-ray diffraction spectrometry (XRD)	609:644	Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectrometry (XRD), scanning electron microscopy (SEM) and compression tests were performed to assess suitability of composite biomaterial.
32147344	2	51	theme	new	344:346	arg1	type					348:351	a new type	342:351	a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO)	342:439	In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially.
32147344	1	52	theme	appropriate	243:253	arg1	biocompatibility					255:270	appropriate biocompatibility	243:270	appropriate biocompatibility	243:270	Designing novel biomaterials for tissue engineering purpose is an obvious necessary considering ever increasing need for appropriate biocompatibility and properties to achieve the maximum regeneration.
32147344	2	53	theme	based	485:489	arg1	hydrogel					491:498	chitosan based hydrogel	476:498	chitosan based hydrogel	476:498	In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially.
32147344	6	54	theme	vapor	1141:1145	arg1	WVTR					1164:1167	WVTR	1164:1167	WVTR	1164:1167	Chitosan hydrogel swelling ratio was declined from 800 to 200% by PPS/rGO addition; likewise, water vapor transition rate (WVTR) was dropped.
32147344	6	54	theme	vapor	1141:1145	arg1	rate					1158:1161	water vapor transition rate	1135:1161	water vapor transition rate (WVTR)	1135:1168	Chitosan hydrogel swelling ratio was declined from 800 to 200% by PPS/rGO addition; likewise, water vapor transition rate (WVTR) was dropped.
32147344	7	55	dep	engineering	1300:1310	arg1	uses					1312:1315	uses	1312:1315	uses	1312:1315	A proper biocompatibility and cell attachment was confirmed, where porosity of ca. 80% appeared promising for tissue engineering uses.
32147344	2	56	theme	chitosan	476:483	arg1	hydrogel					491:498	chitosan based hydrogel	476:498	chitosan based hydrogel	476:498	In this research, a new type of biomaterial based on poly (phenylene sulfide) (PPS) and reduced graphene oxide (rGO) was synthesized and applied within chitosan based hydrogel to evaluate its performance as a wound dressing potentially.
32147344	6	57	theme	water	1135:1139	arg1	WVTR					1164:1167	WVTR	1164:1167	WVTR	1164:1167	Chitosan hydrogel swelling ratio was declined from 800 to 200% by PPS/rGO addition; likewise, water vapor transition rate (WVTR) was dropped.
32147344	6	57	theme	water	1135:1139	arg1	rate					1158:1161	water vapor transition rate	1135:1161	water vapor transition rate (WVTR)	1135:1168	Chitosan hydrogel swelling ratio was declined from 800 to 200% by PPS/rGO addition; likewise, water vapor transition rate (WVTR) was dropped.
32147344	1	58	theme	tissue	155:160	arg1	engineering					162:172	tissue engineering	155:172	tissue engineering purpose	155:180	Designing novel biomaterials for tissue engineering purpose is an obvious necessary considering ever increasing need for appropriate biocompatibility and properties to achieve the maximum regeneration.
32829845	5	0	from	application	1147:1157	arg1	packaging					1175:1183	packaging	1175:1183	packaging	1175:1183	The study provides a novel method to prepare the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry.
32829845	5	0	from	application	1147:1157	arg1	printing					1162:1169	printing	1162:1169	printing	1162:1169	The study provides a novel method to prepare the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry.
32829845	5	1	theme	doped	1083:1087	arg1	composites					1100:1109	Yb and Er doped CQDs/DANFC composites	1073:1109	Yb and Er doped CQDs/DANFC composites	1073:1109	The study provides a novel method to prepare the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry.
32829845	3	2	theme	network	707:713	arg1	structure					715:723	a stable network structure	698:723	a stable network structure	698:723	Owning to special rheological properties of NFC, a waterborne fluorescent dual anti-counterfeiting ink was rationally designed and successfully prepared by adding NFC to waterborne ink to form a stable network structure and increase the thixotropy and yield stress.
32829845	1	3	theme	renewability	275:286	arg1	properties					311:320	its favorable biocompatibility, renewability, and easy modification properties	243:320	its favorable biocompatibility, renewability, and easy modification properties	243:320	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	5	4	dep	printing	1162:1169	arg1	industry					1185:1192	industry	1185:1192	industry	1185:1192	The study provides a novel method to prepare the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry.
32829845	3	5	theme	waterborne	675:684	arg1	ink					686:688	waterborne ink	675:688	waterborne ink	675:688	Owning to special rheological properties of NFC, a waterborne fluorescent dual anti-counterfeiting ink was rationally designed and successfully prepared by adding NFC to waterborne ink to form a stable network structure and increase the thixotropy and yield stress.
32829845	0	6	theme	nano-fibrillated	111:126	arg1	cellulose					128:136	dialdehyde nano-fibrillated cellulose	100:136	dialdehyde nano-fibrillated cellulose	100:136	Waterborne fluorescent dual anti-counterfeiting ink based on Yb/Er-carbon quantum dots grafted with dialdehyde nano-fibrillated cellulose.
32829845	1	7	theme	carbon	368:373	arg1	dots					383:386	carbon quantum dots	368:386	carbon quantum dots (CQDs)	368:393	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	1	7	theme	carbon	368:373	arg1	CQDs					389:392	CQDs	389:392	CQDs	389:392	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	1	8	from	popular	183:189	arg1	field					198:202	the field	194:202	the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs)	194:393	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	3	9	theme	special	515:521	arg1	properties					535:544	special rheological properties	515:544	special rheological properties of NFC	515:551	Owning to special rheological properties of NFC, a waterborne fluorescent dual anti-counterfeiting ink was rationally designed and successfully prepared by adding NFC to waterborne ink to form a stable network structure and increase the thixotropy and yield stress.
32829845	0	10	theme	dialdehyde	100:109	arg1	cellulose					128:136	dialdehyde nano-fibrillated cellulose	100:136	dialdehyde nano-fibrillated cellulose	100:136	Waterborne fluorescent dual anti-counterfeiting ink based on Yb/Er-carbon quantum dots grafted with dialdehyde nano-fibrillated cellulose.
32829845	1	11	theme	quantum	375:381	arg1	dots					383:386	carbon quantum dots	368:386	carbon quantum dots (CQDs)	368:393	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	1	11	theme	quantum	375:381	arg1	CQDs					389:392	CQDs	389:392	CQDs	389:392	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	3	12	theme	rheological	523:533	arg1	properties					535:544	special rheological properties	515:544	special rheological properties of NFC	515:551	Owning to special rheological properties of NFC, a waterborne fluorescent dual anti-counterfeiting ink was rationally designed and successfully prepared by adding NFC to waterborne ink to form a stable network structure and increase the thixotropy and yield stress.
32829845	1	13	theme	easy	293:296	arg1	modification					298:309	easy modification	293:309	easy modification	293:309	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	4	14	theme	980	941:943	arg1	nm					945:946	370 and 980 nm	933:946	nm	945:946	The resulting CQDs exhibited both photoluminescence (PL) and up-conversion luminescence (UCPL), emitting blue and green fluorescence at excitation wavelengths of 370 and 980 nm, respectively.
32829845	1	15	theme	dots	383:386	arg1	carrier					357:363	carrier	357:363	carrier of carbon quantum dots (CQDs)	357:393	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	5	16	theme	Er	1080:1081	arg1	composites					1100:1109	Yb and Er doped CQDs/DANFC composites	1073:1109	Yb and Er doped CQDs/DANFC composites	1073:1109	The study provides a novel method to prepare the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry.
32829845	5	17	theme	Yb	1073:1074	arg1	composites					1100:1109	Yb and Er doped CQDs/DANFC composites	1073:1109	Yb and Er doped CQDs/DANFC composites	1073:1109	The study provides a novel method to prepare the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry.
32829845	4	18	theme	nm	945:946	arg1	wavelengths					918:928	excitation wavelengths	907:928	excitation wavelengths of 370 and 980 nm, respectively	907:960	The resulting CQDs exhibited both photoluminescence (PL) and up-conversion luminescence (UCPL), emitting blue and green fluorescence at excitation wavelengths of 370 and 980 nm, respectively.
32829845	0	19	theme	fluorescent	11:21	arg1	ink					48:50	Waterborne fluorescent dual anti-counterfeiting ink	0:50	Waterborne fluorescent dual anti-counterfeiting ink	0:50	Waterborne fluorescent dual anti-counterfeiting ink based on Yb/Er-carbon quantum dots grafted with dialdehyde nano-fibrillated cellulose.
32829845	3	20	theme	stable	700:705	arg1	structure					715:723	a stable network structure	698:723	a stable network structure	698:723	Owning to special rheological properties of NFC, a waterborne fluorescent dual anti-counterfeiting ink was rationally designed and successfully prepared by adding NFC to waterborne ink to form a stable network structure and increase the thixotropy and yield stress.
32829845	3	21	theme	NFC	549:551	arg1	properties					535:544	special rheological properties	515:544	special rheological properties of NFC	515:551	Owning to special rheological properties of NFC, a waterborne fluorescent dual anti-counterfeiting ink was rationally designed and successfully prepared by adding NFC to waterborne ink to form a stable network structure and increase the thixotropy and yield stress.
32829845	0	22	theme	Waterborne	0:9	arg1	ink					48:50	Waterborne fluorescent dual anti-counterfeiting ink	0:50	Waterborne fluorescent dual anti-counterfeiting ink	0:50	Waterborne fluorescent dual anti-counterfeiting ink based on Yb/Er-carbon quantum dots grafted with dialdehyde nano-fibrillated cellulose.
32829845	1	23	theme	modification	298:309	arg1	properties					311:320	its favorable biocompatibility, renewability, and easy modification properties	243:320	its favorable biocompatibility, renewability, and easy modification properties	243:320	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	4	24	theme	up-conversion	832:844	arg1	UCPL					860:863	UCPL	860:863	UCPL	860:863	The resulting CQDs exhibited both photoluminescence (PL) and up-conversion luminescence (UCPL), emitting blue and green fluorescence at excitation wavelengths of 370 and 980 nm, respectively.
32829845	4	24	theme	up-conversion	832:844	arg1	luminescence					846:857	up-conversion luminescence	832:857	up-conversion luminescence (UCPL)	832:864	The resulting CQDs exhibited both photoluminescence (PL) and up-conversion luminescence (UCPL), emitting blue and green fluorescence at excitation wavelengths of 370 and 980 nm, respectively.
32829845	0	25	theme	anti-counterfeiting	28:46	arg1	ink					48:50	Waterborne fluorescent dual anti-counterfeiting ink	0:50	Waterborne fluorescent dual anti-counterfeiting ink	0:50	Waterborne fluorescent dual anti-counterfeiting ink based on Yb/Er-carbon quantum dots grafted with dialdehyde nano-fibrillated cellulose.
32829845	5	26	theme	novel	984:988	arg1	method					990:995	a novel method	982:995	a novel method to prepare the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry	982:1192	The study provides a novel method to prepare the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry.
32829845	1	27	theme	anti-counterfeiting	207:225	arg1	material					227:234	anti-counterfeiting material	207:234	anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs)	207:393	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	0	28	theme	dual	23:26	arg1	ink					48:50	Waterborne fluorescent dual anti-counterfeiting ink	0:50	Waterborne fluorescent dual anti-counterfeiting ink	0:50	Waterborne fluorescent dual anti-counterfeiting ink based on Yb/Er-carbon quantum dots grafted with dialdehyde nano-fibrillated cellulose.
32829845	5	29	theme	anti-counterfeiting	1040:1058	arg1	ink					1060:1062	the waterborne fluorescent dual anti-counterfeiting ink	1008:1062	the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry	1008:1192	The study provides a novel method to prepare the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry.
32829845	2	30	theme	Er	454:455	arg1	CQDs					463:466	Yb and Er doped CQDs	447:466	Yb and Er doped CQDs grafted onto dialdehyde NFC (DANFC)	447:502	Herein, we report an effective method to fabricate Yb and Er doped CQDs grafted onto dialdehyde NFC (DANFC).
32829845	1	31	theme	material	227:234	arg1	field					198:202	the field	194:202	the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs)	194:393	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	3	32	theme	fluorescent	567:577	arg1	ink					604:606	a waterborne fluorescent dual anti-counterfeiting ink	554:606	a waterborne fluorescent dual anti-counterfeiting ink	554:606	Owning to special rheological properties of NFC, a waterborne fluorescent dual anti-counterfeiting ink was rationally designed and successfully prepared by adding NFC to waterborne ink to form a stable network structure and increase the thixotropy and yield stress.
32829845	1	33	theme	due	236:238	arg1	material					227:234	anti-counterfeiting material	207:234	anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs)	207:393	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	2	34	theme	doped	457:461	arg1	CQDs					463:466	Yb and Er doped CQDs	447:466	Yb and Er doped CQDs grafted onto dialdehyde NFC (DANFC)	447:502	Herein, we report an effective method to fabricate Yb and Er doped CQDs grafted onto dialdehyde NFC (DANFC).
32829845	4	35	theme	excitation	907:916	arg1	wavelengths					918:928	excitation wavelengths	907:928	excitation wavelengths of 370 and 980 nm, respectively	907:960	The resulting CQDs exhibited both photoluminescence (PL) and up-conversion luminescence (UCPL), emitting blue and green fluorescence at excitation wavelengths of 370 and 980 nm, respectively.
32829845	3	36	theme	dual	579:582	arg1	ink					604:606	a waterborne fluorescent dual anti-counterfeiting ink	554:606	a waterborne fluorescent dual anti-counterfeiting ink	554:606	Owning to special rheological properties of NFC, a waterborne fluorescent dual anti-counterfeiting ink was rationally designed and successfully prepared by adding NFC to waterborne ink to form a stable network structure and increase the thixotropy and yield stress.
32829845	0	37	theme	Yb/Er-carbon	61:72	arg1	dots					82:85	Yb/Er-carbon quantum dots	61:85	Yb/Er-carbon quantum dots grafted with dialdehyde nano-fibrillated cellulose	61:136	Waterborne fluorescent dual anti-counterfeiting ink based on Yb/Er-carbon quantum dots grafted with dialdehyde nano-fibrillated cellulose.
32829845	4	38	theme	370	933:935	arg1	nm					945:946	370 and 980 nm	933:946	nm	945:946	The resulting CQDs exhibited both photoluminescence (PL) and up-conversion luminescence (UCPL), emitting blue and green fluorescence at excitation wavelengths of 370 and 980 nm, respectively.
32829845	4	39	theme	blue	876:879	arg1	fluorescence					891:902	blue and green fluorescence	876:902	blue and green fluorescence	876:902	The resulting CQDs exhibited both photoluminescence (PL) and up-conversion luminescence (UCPL), emitting blue and green fluorescence at excitation wavelengths of 370 and 980 nm, respectively.
32829845	2	40	theme	dialdehyde	481:490	arg1	DANFC					497:501	DANFC	497:501	DANFC	497:501	Herein, we report an effective method to fabricate Yb and Er doped CQDs grafted onto dialdehyde NFC (DANFC).
32829845	2	40	theme	dialdehyde	481:490	arg1	NFC					492:494	dialdehyde NFC	481:494	dialdehyde NFC (DANFC)	481:502	Herein, we report an effective method to fabricate Yb and Er doped CQDs grafted onto dialdehyde NFC (DANFC).
32829845	1	41	theme	Nanofibrillated	139:153	arg1	NFC					166:168	NFC	166:168	NFC	166:168	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	1	41	theme	Nanofibrillated	139:153	arg1	cellulose					155:163	Nanofibrillated cellulose	139:163	Nanofibrillated cellulose (NFC)	139:169	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	1	42	theme	great	337:341	arg1	potentials					343:352	great potentials	337:352	great potentials as carrier of carbon quantum dots (CQDs)	337:393	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	3	43	theme	waterborne	556:565	arg1	ink					604:606	a waterborne fluorescent dual anti-counterfeiting ink	554:606	a waterborne fluorescent dual anti-counterfeiting ink	554:606	Owning to special rheological properties of NFC, a waterborne fluorescent dual anti-counterfeiting ink was rationally designed and successfully prepared by adding NFC to waterborne ink to form a stable network structure and increase the thixotropy and yield stress.
32829845	4	44	theme	green	885:889	arg1	fluorescence					891:902	blue and green fluorescence	876:902	blue and green fluorescence	876:902	The resulting CQDs exhibited both photoluminescence (PL) and up-conversion luminescence (UCPL), emitting blue and green fluorescence at excitation wavelengths of 370 and 980 nm, respectively.
32829845	5	45	theme	waterborne	1012:1021	arg1	ink					1060:1062	the waterborne fluorescent dual anti-counterfeiting ink	1008:1062	the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry	1008:1192	The study provides a novel method to prepare the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry.
32829845	4	46	theme	resulting	775:783	arg1	CQDs					785:788	The resulting CQDs	771:788	The resulting CQDs	771:788	The resulting CQDs exhibited both photoluminescence (PL) and up-conversion luminescence (UCPL), emitting blue and green fluorescence at excitation wavelengths of 370 and 980 nm, respectively.
32829845	5	47	theme	fluorescent	1023:1033	arg1	ink					1060:1062	the waterborne fluorescent dual anti-counterfeiting ink	1008:1062	the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry	1008:1192	The study provides a novel method to prepare the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry.
32829845	1	48	from	field	198:202	arg1	popular					183:189	popular	183:189	popular	183:189	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	1	49	theme	favorable	247:255	arg1	biocompatibility					257:272	its favorable biocompatibility	243:272	its favorable biocompatibility	243:272	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	5	50	theme	dual	1035:1038	arg1	ink					1060:1062	the waterborne fluorescent dual anti-counterfeiting ink	1008:1062	the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry	1008:1192	The study provides a novel method to prepare the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry.
32829845	3	51	theme	anti-counterfeiting	584:602	arg1	ink					604:606	a waterborne fluorescent dual anti-counterfeiting ink	554:606	a waterborne fluorescent dual anti-counterfeiting ink	554:606	Owning to special rheological properties of NFC, a waterborne fluorescent dual anti-counterfeiting ink was rationally designed and successfully prepared by adding NFC to waterborne ink to form a stable network structure and increase the thixotropy and yield stress.
32829845	2	52	theme	effective	417:425	arg1	method					427:432	an effective method	414:432	an effective method to fabricate Yb and Er doped CQDs grafted onto dialdehyde NFC (DANFC)	414:502	Herein, we report an effective method to fabricate Yb and Er doped CQDs grafted onto dialdehyde NFC (DANFC).
32829845	1	53	theme	biocompatibility	257:272	arg1	properties					311:320	its favorable biocompatibility, renewability, and easy modification properties	243:320	its favorable biocompatibility, renewability, and easy modification properties	243:320	Nanofibrillated cellulose (NFC) is becoming popular in the field of anti-counterfeiting material due to its favorable biocompatibility, renewability, and easy modification properties, which give it great potentials as carrier of carbon quantum dots (CQDs).
32829845	0	54	theme	quantum	74:80	arg1	dots					82:85	Yb/Er-carbon quantum dots	61:85	Yb/Er-carbon quantum dots grafted with dialdehyde nano-fibrillated cellulose	61:136	Waterborne fluorescent dual anti-counterfeiting ink based on Yb/Er-carbon quantum dots grafted with dialdehyde nano-fibrillated cellulose.
32829845	5	55	theme	CQDs/DANFC	1089:1098	arg1	composites					1100:1109	Yb and Er doped CQDs/DANFC composites	1073:1109	Yb and Er doped CQDs/DANFC composites	1073:1109	The study provides a novel method to prepare the waterborne fluorescent dual anti-counterfeiting ink based on Yb and Er doped CQDs/DANFC composites, which provides a reference for its application in printing and packaging industry.
32829845	2	56	theme	Yb	447:448	arg1	CQDs					463:466	Yb and Er doped CQDs	447:466	Yb and Er doped CQDs grafted onto dialdehyde NFC (DANFC)	447:502	Herein, we report an effective method to fabricate Yb and Er doped CQDs grafted onto dialdehyde NFC (DANFC).
34229397	0	0	theme	blue	92:95	arg1	methylene					82:90	methylene blue	82:95	methylene blue	82:95	Recyclable polyurethane foam loaded with carboxymethyl chitosan for adsorption of methylene blue.
34229397	7	1	theme	pore	979:982	arg1	sizes					984:988	the pore sizes	975:988	the pore sizes	975:988	MIP characterization result showed the porosity of CMCTS-PUF-5 was 73.99% and the pore sizes were mainly distributed between 50 and 150 µm, which provide sufficient diffusion channels and active sites for MB dyes.
34229397	2	2	theme	optimal	341:347	arg1	CMCTS-PUF-5					365:375	the optimal composite foam (CMCTS-PUF-5)	337:376	the optimal composite foam (CMCTS-PUF-5)	337:376	The adsorption capacity of the optimal composite foam (CMCTS-PUF-5) reached to 118.2 mg/g with 5% CMCTS loading.
34229397	1	3	theme	amino	229:233	arg1	groups					235:240	amino groups	229:240	amino groups in CMCTS	229:249	Novel composite foam (CMCTS-PUF-s) was prepared by immobilizing carboxymethyl chitosan (CMCTS) on polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer.
34229397	0	4	theme	methylene	82:90	arg1	adsorption					68:77	adsorption	68:77	adsorption of methylene blue	68:95	Recyclable polyurethane foam loaded with carboxymethyl chitosan for adsorption of methylene blue.
34229397	5	5	theme	characterization	684:699	arg1	results					701:707	The characterization results	680:707	The characterization results of FTIR and TG	680:722	The characterization results of FTIR and TG showed that CMCTS was well loaded on PUF by covalent bond.
34229397	1	6	theme	carboxymethyl	162:174	arg1	CMCTS					186:190	CMCTS	186:190	CMCTS	186:190	Novel composite foam (CMCTS-PUF-s) was prepared by immobilizing carboxymethyl chitosan (CMCTS) on polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer.
34229397	1	6	theme	carboxymethyl	162:174	arg1	chitosan					176:183	carboxymethyl chitosan	162:183	carboxymethyl chitosan (CMCTS)	162:191	Novel composite foam (CMCTS-PUF-s) was prepared by immobilizing carboxymethyl chitosan (CMCTS) on polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer.
34229397	7	7	theme	sufficient	1051:1060	arg1	channels					1072:1079	sufficient diffusion channels	1051:1079	sufficient diffusion channels	1051:1079	MIP characterization result showed the porosity of CMCTS-PUF-5 was 73.99% and the pore sizes were mainly distributed between 50 and 150 µm, which provide sufficient diffusion channels and active sites for MB dyes.
34229397	9	8	theme	future	1422:1427	arg1	treatment					1429:1437	future treatment	1422:1437	future treatment of dye wastewater	1422:1455	Therefore, CMCTS-PUF-s presents excellent recoverability, high stability and attractive adsorption efficiency, shows the potential application in future treatment of dye wastewater.
34229397	9	9	theme	dye	1442:1444	arg1	wastewater					1446:1455	dye wastewater	1442:1455	dye wastewater	1442:1455	Therefore, CMCTS-PUF-s presents excellent recoverability, high stability and attractive adsorption efficiency, shows the potential application in future treatment of dye wastewater.
34229397	9	10	theme	excellent	1308:1316	arg1	recoverability					1318:1331	excellent recoverability	1308:1331	excellent recoverability	1308:1331	Therefore, CMCTS-PUF-s presents excellent recoverability, high stability and attractive adsorption efficiency, shows the potential application in future treatment of dye wastewater.
34229397	7	11	theme	diffusion	1062:1070	arg1	channels					1072:1079	sufficient diffusion channels	1051:1079	sufficient diffusion channels	1051:1079	MIP characterization result showed the porosity of CMCTS-PUF-5 was 73.99% and the pore sizes were mainly distributed between 50 and 150 µm, which provide sufficient diffusion channels and active sites for MB dyes.
34229397	6	12	theme	Young	787:791	arg1	modulus					795:801	The Young's modulus	783:801	The Young's modulus	783:801	The Young's modulus and tensile strength of CMCTS-PUF-5 were increased by 252% and 97% compared with that of PUF.
34229397	8	13	dep	kinetics	1126:1133	arg1	The					1111:1113	The	1111:1113	The	1111:1113	The adsorption kinetics and isotherm proved pseudo-second-order kinetic model and Langmuir isotherm model could well describe the adsorption process of CMCTS-PUF-5.
34229397	7	14	theme	MB	1102:1103	arg1	dyes					1105:1108	MB dyes	1102:1108	MB dyes	1102:1108	MIP characterization result showed the porosity of CMCTS-PUF-5 was 73.99% and the pore sizes were mainly distributed between 50 and 150 µm, which provide sufficient diffusion channels and active sites for MB dyes.
34229397	8	15	theme	isotherm	1202:1209	arg1	model					1211:1215	Langmuir isotherm model	1193:1215	Langmuir isotherm model	1193:1215	The adsorption kinetics and isotherm proved pseudo-second-order kinetic model and Langmuir isotherm model could well describe the adsorption process of CMCTS-PUF-5.
34229397	9	16	theme	attractive	1353:1362	arg1	adsorption					1364:1373	attractive adsorption	1353:1373	attractive adsorption	1353:1373	Therefore, CMCTS-PUF-s presents excellent recoverability, high stability and attractive adsorption efficiency, shows the potential application in future treatment of dye wastewater.
34229397	8	17	theme	pseudo-second-order	1155:1173	arg1	model					1183:1187	pseudo-second-order kinetic model	1155:1187	pseudo-second-order kinetic model	1155:1187	The adsorption kinetics and isotherm proved pseudo-second-order kinetic model and Langmuir isotherm model could well describe the adsorption process of CMCTS-PUF-5.
34229397	9	18	theme	adsorption	1364:1373	arg1	efficiency					1375:1384	excellent recoverability, high stability and attractive adsorption efficiency	1308:1384	excellent recoverability, high stability and attractive adsorption efficiency	1308:1384	Therefore, CMCTS-PUF-s presents excellent recoverability, high stability and attractive adsorption efficiency, shows the potential application in future treatment of dye wastewater.
34229397	9	19	theme	stability	1339:1347	arg1	efficiency					1375:1384	excellent recoverability, high stability and attractive adsorption efficiency	1308:1384	excellent recoverability, high stability and attractive adsorption efficiency	1308:1384	Therefore, CMCTS-PUF-s presents excellent recoverability, high stability and attractive adsorption efficiency, shows the potential application in future treatment of dye wastewater.
34229397	9	20	theme	recoverability	1318:1331	arg1	efficiency					1375:1384	excellent recoverability, high stability and attractive adsorption efficiency	1308:1384	excellent recoverability, high stability and attractive adsorption efficiency	1308:1384	Therefore, CMCTS-PUF-s presents excellent recoverability, high stability and attractive adsorption efficiency, shows the potential application in future treatment of dye wastewater.
34229397	9	21	from	application	1407:1417	arg1	treatment					1429:1437	future treatment	1422:1437	future treatment of dye wastewater	1422:1455	Therefore, CMCTS-PUF-s presents excellent recoverability, high stability and attractive adsorption efficiency, shows the potential application in future treatment of dye wastewater.
34229397	1	22	from	groups	275:280	arg1	prepolymer					298:307	polyurethane prepolymer	285:307	polyurethane prepolymer	285:307	Novel composite foam (CMCTS-PUF-s) was prepared by immobilizing carboxymethyl chitosan (CMCTS) on polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer.
34229397	5	23	theme	TG	721:722	arg1	results					701:707	The characterization results	680:707	The characterization results of FTIR and TG	680:722	The characterization results of FTIR and TG showed that CMCTS was well loaded on PUF by covalent bond.
34229397	4	24	theme	removal	562:568	arg1	rate					570:573	the removal rate	558:573	the removal rate	558:573	After recycling for five times, the removal rate still reached 83.2%, which strongly proved the excellent reusability of immobilizing CMCTS modified PUF.
34229397	0	25	theme	polyurethane	11:22	arg1	foam					24:27	Recyclable polyurethane foam	0:27	Recyclable polyurethane foam	0:27	Recyclable polyurethane foam loaded with carboxymethyl chitosan for adsorption of methylene blue.
34229397	7	26	theme	CMCTS-PUF-5	948:958	arg1	porosity					936:943	the porosity	932:943	the porosity of CMCTS-PUF-5	932:958	MIP characterization result showed the porosity of CMCTS-PUF-5 was 73.99% and the pore sizes were mainly distributed between 50 and 150 µm, which provide sufficient diffusion channels and active sites for MB dyes.
34229397	7	27	dep	showed	925:930	arg1	%					969:969	73.99%	964:969	73.99%	964:969	MIP characterization result showed the porosity of CMCTS-PUF-5 was 73.99% and the pore sizes were mainly distributed between 50 and 150 µm, which provide sufficient diffusion channels and active sites for MB dyes.
34229397	8	28	theme	adsorption	1241:1250	arg1	process					1252:1258	the adsorption process	1237:1258	the adsorption process of CMCTS-PUF-5	1237:1273	The adsorption kinetics and isotherm proved pseudo-second-order kinetic model and Langmuir isotherm model could well describe the adsorption process of CMCTS-PUF-5.
34229397	2	29	theme	CMCTS-PUF-5	365:375	arg1	capacity					325:332	The adsorption capacity	310:332	The adsorption capacity of the optimal composite foam (CMCTS-PUF-5)	310:376	The adsorption capacity of the optimal composite foam (CMCTS-PUF-5) reached to 118.2 mg/g with 5% CMCTS loading.
34229397	0	30	theme	Recyclable	0:9	arg1	foam					24:27	Recyclable polyurethane foam	0:27	Recyclable polyurethane foam	0:27	Recyclable polyurethane foam loaded with carboxymethyl chitosan for adsorption of methylene blue.
34229397	1	31	theme	Novel	98:102	arg1	CMCTS-PUF-s					120:130	CMCTS-PUF-s	120:130	CMCTS-PUF-s	120:130	Novel composite foam (CMCTS-PUF-s) was prepared by immobilizing carboxymethyl chitosan (CMCTS) on polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer.
34229397	1	31	theme	Novel	98:102	arg1	foam					114:117	Novel composite foam	98:117	Novel composite foam (CMCTS-PUF-s)	98:131	Novel composite foam (CMCTS-PUF-s) was prepared by immobilizing carboxymethyl chitosan (CMCTS) on polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer.
34229397	5	32	theme	covalent	768:775	arg1	bond					777:780	covalent bond	768:780	covalent bond	768:780	The characterization results of FTIR and TG showed that CMCTS was well loaded on PUF by covalent bond.
34229397	2	33	theme	CMCTS	408:412	arg1	loading					414:420	5% CMCTS loading	405:420	5% CMCTS loading	405:420	The adsorption capacity of the optimal composite foam (CMCTS-PUF-5) reached to 118.2 mg/g with 5% CMCTS loading.
34229397	8	34	theme	kinetic	1175:1181	arg1	model					1183:1187	pseudo-second-order kinetic model	1155:1187	pseudo-second-order kinetic model	1155:1187	The adsorption kinetics and isotherm proved pseudo-second-order kinetic model and Langmuir isotherm model could well describe the adsorption process of CMCTS-PUF-5.
34229397	1	35	theme	composite	104:112	arg1	CMCTS-PUF-s					120:130	CMCTS-PUF-s	120:130	CMCTS-PUF-s	120:130	Novel composite foam (CMCTS-PUF-s) was prepared by immobilizing carboxymethyl chitosan (CMCTS) on polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer.
34229397	1	35	theme	composite	104:112	arg1	foam					114:117	Novel composite foam	98:117	Novel composite foam (CMCTS-PUF-s)	98:131	Novel composite foam (CMCTS-PUF-s) was prepared by immobilizing carboxymethyl chitosan (CMCTS) on polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer.
34229397	2	36	theme	5	405:405	arg1	%					406:406	%	406:406	%	406:406	The adsorption capacity of the optimal composite foam (CMCTS-PUF-5) reached to 118.2 mg/g with 5% CMCTS loading.
34229397	2	37	theme	%	406:406	arg1	loading					414:420	5% CMCTS loading	405:420	5% CMCTS loading	405:420	The adsorption capacity of the optimal composite foam (CMCTS-PUF-5) reached to 118.2 mg/g with 5% CMCTS loading.
34229397	1	38	theme	isocyanate	264:273	arg1	groups					275:280	isocyanate groups	264:280	isocyanate groups in polyurethane prepolymer	264:307	Novel composite foam (CMCTS-PUF-s) was prepared by immobilizing carboxymethyl chitosan (CMCTS) on polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer.
34229397	9	39	theme	potential	1397:1405	arg1	application					1407:1417	the potential application	1393:1417	the potential application in future treatment of dye wastewater	1393:1455	Therefore, CMCTS-PUF-s presents excellent recoverability, high stability and attractive adsorption efficiency, shows the potential application in future treatment of dye wastewater.
34229397	4	40	theme	immobilizing	647:658	arg1	CMCTS					660:664	immobilizing CMCTS	647:664	immobilizing CMCTS modified PUF	647:677	After recycling for five times, the removal rate still reached 83.2%, which strongly proved the excellent reusability of immobilizing CMCTS modified PUF.
34229397	1	41	theme	polyurethane	196:207	arg1	PUF					215:217	PUF	215:217	PUF	215:217	Novel composite foam (CMCTS-PUF-s) was prepared by immobilizing carboxymethyl chitosan (CMCTS) on polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer.
34229397	1	41	theme	polyurethane	196:207	arg1	foam					209:212	polyurethane foam	196:212	polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer	196:307	Novel composite foam (CMCTS-PUF-s) was prepared by immobilizing carboxymethyl chitosan (CMCTS) on polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer.
34229397	0	42	theme	carboxymethyl	41:53	arg1	chitosan					55:62	carboxymethyl chitosan	41:62	carboxymethyl chitosan for adsorption of methylene blue	41:95	Recyclable polyurethane foam loaded with carboxymethyl chitosan for adsorption of methylene blue.
34229397	8	43	theme	Langmuir	1193:1200	arg1	model					1211:1215	Langmuir isotherm model	1193:1215	Langmuir isotherm model	1193:1215	The adsorption kinetics and isotherm proved pseudo-second-order kinetic model and Langmuir isotherm model could well describe the adsorption process of CMCTS-PUF-5.
34229397	1	44	from	groups	235:240	arg1	CMCTS					245:249	CMCTS	245:249	CMCTS	245:249	Novel composite foam (CMCTS-PUF-s) was prepared by immobilizing carboxymethyl chitosan (CMCTS) on polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer.
34229397	3	45	theme	PUF	521:523	arg1	PUF					521:523	PUF	521:523	PUF	521:523	The removal rate to methylene blue (MB) was up to 97.1%, which was obviously higher than 18.9% of PUF.
34229397	3	45	theme	PUF	521:523	arg1	%					516:516	18.9%	512:516	18.9% of PUF	512:523	The removal rate to methylene blue (MB) was up to 97.1%, which was obviously higher than 18.9% of PUF.
34229397	3	46	theme	removal	427:433	arg1	rate					435:438	The removal rate	423:438	The removal rate to methylene blue (MB)	423:461	The removal rate to methylene blue (MB) was up to 97.1%, which was obviously higher than 18.9% of PUF.
34229397	3	46	theme	removal	427:433	arg1	%					477:477	up to 97.1%	467:477	up to 97.1%	467:477	The removal rate to methylene blue (MB) was up to 97.1%, which was obviously higher than 18.9% of PUF.
34229397	1	47	theme	polyurethane	285:296	arg1	prepolymer					298:307	polyurethane prepolymer	285:307	polyurethane prepolymer	285:307	Novel composite foam (CMCTS-PUF-s) was prepared by immobilizing carboxymethyl chitosan (CMCTS) on polyurethane foam (PUF) in which amino groups in CMCTS reacted with isocyanate groups in polyurethane prepolymer.
34229397	7	48	theme	characterization	901:916	arg1	result					918:923	MIP characterization result	897:923	MIP characterization result	897:923	MIP characterization result showed the porosity of CMCTS-PUF-5 was 73.99% and the pore sizes were mainly distributed between 50 and 150 µm, which provide sufficient diffusion channels and active sites for MB dyes.
34229397	3	49	dep	97.1	473:476	arg1	to					470:471	to	470:471	to	470:471	The removal rate to methylene blue (MB) was up to 97.1%, which was obviously higher than 18.9% of PUF.
34229397	5	50	theme	FTIR	712:715	arg1	results					701:707	The characterization results	680:707	The characterization results of FTIR and TG	680:722	The characterization results of FTIR and TG showed that CMCTS was well loaded on PUF by covalent bond.
34229397	6	51	dep	increased	844:852	arg1	compared					870:877	compared	870:877	compared with that of PUF	870:894	The Young's modulus and tensile strength of CMCTS-PUF-5 were increased by 252% and 97% compared with that of PUF.
34229397	8	52	theme	CMCTS-PUF-5	1263:1273	arg1	process					1252:1258	the adsorption process	1237:1258	the adsorption process of CMCTS-PUF-5	1237:1273	The adsorption kinetics and isotherm proved pseudo-second-order kinetic model and Langmuir isotherm model could well describe the adsorption process of CMCTS-PUF-5.
34229397	2	53	theme	adsorption	314:323	arg1	capacity					325:332	The adsorption capacity	310:332	The adsorption capacity of the optimal composite foam (CMCTS-PUF-5)	310:376	The adsorption capacity of the optimal composite foam (CMCTS-PUF-5) reached to 118.2 mg/g with 5% CMCTS loading.
34229397	4	54	theme	CMCTS	660:664	arg1	reusability					632:642	the excellent reusability	618:642	the excellent reusability of immobilizing CMCTS modified PUF	618:677	After recycling for five times, the removal rate still reached 83.2%, which strongly proved the excellent reusability of immobilizing CMCTS modified PUF.
34229397	7	55	theme	MIP	897:899	arg1	characterization					901:916	MIP characterization	897:916	MIP characterization result	897:923	MIP characterization result showed the porosity of CMCTS-PUF-5 was 73.99% and the pore sizes were mainly distributed between 50 and 150 µm, which provide sufficient diffusion channels and active sites for MB dyes.
34229397	3	56	theme	blue	453:456	arg1	methylene					443:451	methylene blue	443:456	methylene blue (MB)	443:461	The removal rate to methylene blue (MB) was up to 97.1%, which was obviously higher than 18.9% of PUF.
34229397	3	56	theme	blue	453:456	arg1	MB					459:460	MB	459:460	MB	459:460	The removal rate to methylene blue (MB) was up to 97.1%, which was obviously higher than 18.9% of PUF.
34229397	4	57	theme	excellent	622:630	arg1	reusability					632:642	the excellent reusability	618:642	the excellent reusability of immobilizing CMCTS modified PUF	618:677	After recycling for five times, the removal rate still reached 83.2%, which strongly proved the excellent reusability of immobilizing CMCTS modified PUF.
34229397	7	58	theme	active	1085:1090	arg1	sites					1092:1096	active sites	1085:1096	active sites for MB dyes	1085:1108	MIP characterization result showed the porosity of CMCTS-PUF-5 was 73.99% and the pore sizes were mainly distributed between 50 and 150 µm, which provide sufficient diffusion channels and active sites for MB dyes.
34229397	9	59	dep	presents	1299:1306	arg1	shows					1387:1391	shows	1387:1391	shows the potential application in future treatment of dye wastewater	1387:1455	Therefore, CMCTS-PUF-s presents excellent recoverability, high stability and attractive adsorption efficiency, shows the potential application in future treatment of dye wastewater.
34229397	8	60	theme	adsorption	1115:1124	arg1	kinetics					1126:1133	adsorption kinetics	1115:1133	adsorption kinetics	1115:1133	The adsorption kinetics and isotherm proved pseudo-second-order kinetic model and Langmuir isotherm model could well describe the adsorption process of CMCTS-PUF-5.
34229397	2	61	theme	foam	359:362	arg1	CMCTS-PUF-5					365:375	the optimal composite foam (CMCTS-PUF-5)	337:376	the optimal composite foam (CMCTS-PUF-5)	337:376	The adsorption capacity of the optimal composite foam (CMCTS-PUF-5) reached to 118.2 mg/g with 5% CMCTS loading.
34229397	9	62	theme	high	1334:1337	arg1	stability					1339:1347	high stability	1334:1347	high stability	1334:1347	Therefore, CMCTS-PUF-s presents excellent recoverability, high stability and attractive adsorption efficiency, shows the potential application in future treatment of dye wastewater.
34229397	9	63	theme	wastewater	1446:1455	arg1	treatment					1429:1437	future treatment	1422:1437	future treatment of dye wastewater	1422:1455	Therefore, CMCTS-PUF-s presents excellent recoverability, high stability and attractive adsorption efficiency, shows the potential application in future treatment of dye wastewater.
34229397	6	64	theme	tensile	807:813	arg1	strength					815:822	tensile strength	807:822	tensile strength of CMCTS-PUF-5	807:837	The Young's modulus and tensile strength of CMCTS-PUF-5 were increased by 252% and 97% compared with that of PUF.
34229397	2	65	theme	composite	349:357	arg1	CMCTS-PUF-5					365:375	the optimal composite foam (CMCTS-PUF-5)	337:376	the optimal composite foam (CMCTS-PUF-5)	337:376	The adsorption capacity of the optimal composite foam (CMCTS-PUF-5) reached to 118.2 mg/g with 5% CMCTS loading.
34229397	6	66	theme	CMCTS-PUF-5	827:837	arg1	modulus					795:801	The Young's modulus	783:801	The Young's modulus	783:801	The Young's modulus and tensile strength of CMCTS-PUF-5 were increased by 252% and 97% compared with that of PUF.
34229397	6	66	theme	CMCTS-PUF-5	827:837	arg1	strength					815:822	tensile strength	807:822	tensile strength of CMCTS-PUF-5	807:837	The Young's modulus and tensile strength of CMCTS-PUF-5 were increased by 252% and 97% compared with that of PUF.
33892041	5	0	from	K	893:893	arg1	min					869:871	5, 180 min	862:871	min	869:871	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	5	0	from	K	893:893	arg1	mg/L					881:884	100 mg/L	877:884	100 mg/L at 293 K	877:893	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	5	0	from	K	893:893	arg1	value					808:812	the pH value	801:812	the pH value	801:812	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	5	1	theme	pH	805:806	arg1	min					869:871	5, 180 min	862:871	min	869:871	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	5	1	theme	pH	805:806	arg1	concentration					843:855	Hg(II) ion concentration	832:855	Hg(II) ion concentration	832:855	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	5	1	theme	pH	805:806	arg1	value					808:812	the pH value	801:812	the pH value	801:812	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	5	1	theme	pH	805:806	arg1	time					826:829	adsorption time	815:829	adsorption time	815:829	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	9	2	with	MCP	1303:1305	arg1	reusability					1362:1372	highly stable and efficient, as well as excellent reusability	1312:1372	highly stable and efficient, as well as excellent reusability	1312:1372	All in all, MCP with highly stable and efficient, as well as excellent reusability will be a candidate for industry-level applications from wastewater with Hg(II) ions.
33892041	0	3	theme	ions	43:46	arg1	removal					25:31	Rapid and high selective removal	0:31	Rapid and high selective removal of Hg(II) ions	0:46	Rapid and high selective removal of Hg(II) ions using tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite.
33892041	4	4	theme	excellent	608:616	arg1	selectivity					618:628	an excellent selectivity	605:628	an excellent selectivity	605:628	The results showed that MCP exhibited an excellent selectivity and reutilization, fast removal rate, and very high adsorption capacity.
33892041	5	5	theme	Hg	832:833	arg1	concentration					843:855	Hg(II) ion concentration	832:855	Hg(II) ion concentration	832:855	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	5	5	theme	Hg	832:833	arg1	value					808:812	the pH value	801:812	the pH value	801:812	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	0	6	theme	acid	61:64	arg1	composite					132:140	tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite	54:140	tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite	54:140	Rapid and high selective removal of Hg(II) ions using tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite.
33892041	6	7	theme	adsorption	1035:1044	arg1	process					1046:1052	the chemical adsorption process	1022:1052	the chemical adsorption process	1022:1052	The kinetics followed the pseudo-second-order, which indicated that the adsorption behavior of MCP for Hg(II) ion belonged to the chemical adsorption process and external diffusion.
33892041	5	8	dep	capacity	732:739	arg1	The					703:705	The	703:705	The	703:705	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	3	9	theme	Hg	469:470	arg1	concentration					480:492	initial Hg(II) ion concentration	461:492	initial Hg(II) ion concentration	461:492	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior was investigated.
33892041	9	10	from	candidate	1384:1392	arg1	all					1298:1300	all	1298:1300	all	1298:1300	All in all, MCP with highly stable and efficient, as well as excellent reusability will be a candidate for industry-level applications from wastewater with Hg(II) ions.
33892041	0	11	theme	tannic	54:59	arg1	composite					132:140	tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite	54:140	tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite	54:140	Rapid and high selective removal of Hg(II) ions using tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite.
33892041	7	12	theme	thermodynamic	1082:1094	arg1	study					1096:1100	The thermodynamic study	1078:1100	The thermodynamic study	1078:1100	The thermodynamic study showed that the adsorption process was a spontaneous and exothermic process.
33892041	1	13	theme	adsorbent	271:279	arg1	composite					242:250	cellulose/polyethyleneimine functionalized magnetic composite	190:250	cellulose/polyethyleneimine functionalized magnetic composite (MCP)	190:256	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	1	13	theme	adsorbent	271:279	arg1	biomass					263:269	a biomass adsorbent	261:279	a biomass adsorbent of Hg(II) ions	261:294	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	0	14	theme	cellulose/polyethyleneimine	80:106	arg1	composite					132:140	tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite	54:140	tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite	54:140	Rapid and high selective removal of Hg(II) ions using tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite.
33892041	7	15	theme	adsorption	1118:1127	arg1	process					1170:1176	a spontaneous and exothermic process	1141:1176	a spontaneous and exothermic process	1141:1176	The thermodynamic study showed that the adsorption process was a spontaneous and exothermic process.
33892041	7	15	theme	adsorption	1118:1127	arg1	process					1129:1135	the adsorption process	1114:1135	the adsorption process	1114:1135	The thermodynamic study showed that the adsorption process was a spontaneous and exothermic process.
33892041	9	16	theme	stable	1319:1324	arg1	reusability					1362:1372	highly stable and efficient, as well as excellent reusability	1312:1372	highly stable and efficient, as well as excellent reusability	1312:1372	All in all, MCP with highly stable and efficient, as well as excellent reusability will be a candidate for industry-level applications from wastewater with Hg(II) ions.
33892041	7	17	theme	exothermic	1159:1168	arg1	process					1170:1176	a spontaneous and exothermic process	1141:1176	a spontaneous and exothermic process	1141:1176	The thermodynamic study showed that the adsorption process was a spontaneous and exothermic process.
33892041	7	17	theme	exothermic	1159:1168	arg1	process					1129:1135	the adsorption process	1114:1135	the adsorption process	1114:1135	The thermodynamic study showed that the adsorption process was a spontaneous and exothermic process.
33892041	0	18	theme	cross-linking	66:78	arg1	composite					132:140	tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite	54:140	tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite	54:140	Rapid and high selective removal of Hg(II) ions using tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite.
33892041	8	19	theme	adsorption-desorption	1195:1215	arg1	experiment					1217:1226	the fifth adsorption-desorption experiment	1185:1226	the fifth adsorption-desorption experiment	1185:1226	After the fifth adsorption-desorption experiment, it still had better adsorption performance and reutilization.
33892041	9	20	theme	excellent	1352:1360	arg1	reusability					1362:1372	highly stable and efficient, as well as excellent reusability	1312:1372	highly stable and efficient, as well as excellent reusability	1312:1372	All in all, MCP with highly stable and efficient, as well as excellent reusability will be a candidate for industry-level applications from wastewater with Hg(II) ions.
33892041	3	21	theme	initial	461:467	arg1	concentration					480:492	initial Hg(II) ion concentration	461:492	initial Hg(II) ion concentration	461:492	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior was investigated.
33892041	1	22	theme	new	160:162	arg1	acid					171:174	a new tannic acid	158:174	a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions	158:294	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	9	23	with	wastewater	1431:1440	arg1	ions					1454:1457	Hg(II) ions	1447:1457	Hg(II) ions	1447:1457	All in all, MCP with highly stable and efficient, as well as excellent reusability will be a candidate for industry-level applications from wastewater with Hg(II) ions.
33892041	9	24	theme	industry-level	1398:1411	arg1	applications					1413:1424	industry-level applications	1398:1424	industry-level applications from wastewater with Hg(II) ions	1398:1457	All in all, MCP with highly stable and efficient, as well as excellent reusability will be a candidate for industry-level applications from wastewater with Hg(II) ions.
33892041	3	25	theme	ion	476:478	arg1	concentration					480:492	initial Hg(II) ion concentration	461:492	initial Hg(II) ion concentration	461:492	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior was investigated.
33892041	1	26	theme	tannic	164:169	arg1	acid					171:174	a new tannic acid	158:174	a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions	158:294	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	0	27	theme	Rapid	0:4	arg1	removal					25:31	Rapid and high selective removal	0:31	Rapid and high selective removal of Hg(II) ions	0:46	Rapid and high selective removal of Hg(II) ions using tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite.
33892041	8	28	theme	fifth	1189:1193	arg1	experiment					1217:1226	the fifth adsorption-desorption experiment	1185:1226	the fifth adsorption-desorption experiment	1185:1226	After the fifth adsorption-desorption experiment, it still had better adsorption performance and reutilization.
33892041	4	29	theme	removal	654:660	arg1	rate					662:665	fast removal rate	649:665	fast removal rate	649:665	The results showed that MCP exhibited an excellent selectivity and reutilization, fast removal rate, and very high adsorption capacity.
33892041	0	30	theme	selective	15:23	arg1	removal					25:31	Rapid and high selective removal	0:31	Rapid and high selective removal of Hg(II) ions	0:46	Rapid and high selective removal of Hg(II) ions using tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite.
33892041	1	31	theme	Hg	284:285	arg1	ions					291:294	Hg(II) ions	284:294	Hg(II) ions	284:294	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	0	32	theme	magnetic	123:130	arg1	composite					132:140	tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite	54:140	tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite	54:140	Rapid and high selective removal of Hg(II) ions using tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite.
33892041	6	33	theme	Hg	999:1000	arg1	ion					1006:1008	Hg(II) ion	999:1008	Hg(II) ion	999:1008	The kinetics followed the pseudo-second-order, which indicated that the adsorption behavior of MCP for Hg(II) ion belonged to the chemical adsorption process and external diffusion.
33892041	8	34	theme	adsorption	1249:1258	arg1	performance					1260:1270	better adsorption performance	1242:1270	better adsorption performance	1242:1270	After the fifth adsorption-desorption experiment, it still had better adsorption performance and reutilization.
33892041	5	35	theme	ion	839:841	arg1	concentration					843:855	Hg(II) ion concentration	832:855	Hg(II) ion concentration	832:855	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	5	35	theme	ion	839:841	arg1	value					808:812	the pH value	801:812	the pH value	801:812	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	0	36	theme	high	10:13	arg1	removal					25:31	Rapid and high selective removal	0:31	Rapid and high selective removal of Hg(II) ions	0:46	Rapid and high selective removal of Hg(II) ions using tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite.
33892041	0	37	theme	functionalized	108:121	arg1	composite					132:140	tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite	54:140	tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite	54:140	Rapid and high selective removal of Hg(II) ions using tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite.
33892041	2	38	dep	morphology	314:323	arg1	The					310:312	The	310:312	The	310:312	The morphology and structure of MCP were characterized with FT-IR, TG, XRD, SEM and TEM.
33892041	1	39	theme	cellulose/polyethyleneimine	190:216	arg1	MCP					253:255	MCP	253:255	MCP	253:255	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	1	39	theme	cellulose/polyethyleneimine	190:216	arg1	composite					242:250	cellulose/polyethyleneimine functionalized magnetic composite	190:250	cellulose/polyethyleneimine functionalized magnetic composite (MCP)	190:256	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	1	39	theme	cellulose/polyethyleneimine	190:216	arg1	biomass					263:269	a biomass adsorbent	261:279	a biomass adsorbent of Hg(II) ions	261:294	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	3	40	theme	adsorption	499:508	arg1	temperature					510:520	adsorption temperature	499:520	adsorption temperature	499:520	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior was investigated.
33892041	1	41	theme	functionalized	218:231	arg1	MCP					253:255	MCP	253:255	MCP	253:255	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	1	41	theme	functionalized	218:231	arg1	composite					242:250	cellulose/polyethyleneimine functionalized magnetic composite	190:250	cellulose/polyethyleneimine functionalized magnetic composite (MCP)	190:256	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	1	41	theme	functionalized	218:231	arg1	biomass					263:269	a biomass adsorbent	261:279	a biomass adsorbent of Hg(II) ions	261:294	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	5	42	theme	removal	745:751	arg1	rate					753:756	removal rate	745:756	removal rate	745:756	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	1	43	theme	magnetic	233:240	arg1	MCP					253:255	MCP	253:255	MCP	253:255	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	1	43	theme	magnetic	233:240	arg1	composite					242:250	cellulose/polyethyleneimine functionalized magnetic composite	190:250	cellulose/polyethyleneimine functionalized magnetic composite (MCP)	190:256	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	1	43	theme	magnetic	233:240	arg1	biomass					263:269	a biomass adsorbent	261:279	a biomass adsorbent of Hg(II) ions	261:294	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	5	44	theme	corresponding	707:719	arg1	capacity					732:739	corresponding adsorption capacity	707:739	corresponding adsorption capacity	707:739	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	1	45	theme	ions	291:294	arg1	composite					242:250	cellulose/polyethyleneimine functionalized magnetic composite	190:250	cellulose/polyethyleneimine functionalized magnetic composite (MCP)	190:256	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	1	45	theme	ions	291:294	arg1	biomass					263:269	a biomass adsorbent	261:279	a biomass adsorbent of Hg(II) ions	261:294	In this study, a new tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite (MCP) as a biomass adsorbent of Hg(II) ions was prepared.
33892041	5	46	theme	adsorption	721:730	arg1	capacity					732:739	corresponding adsorption capacity	707:739	corresponding adsorption capacity	707:739	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	6	47	theme	external	1058:1065	arg1	diffusion					1067:1075	external diffusion	1058:1075	external diffusion	1058:1075	The kinetics followed the pseudo-second-order, which indicated that the adsorption behavior of MCP for Hg(II) ion belonged to the chemical adsorption process and external diffusion.
33892041	3	48	from	effect	403:408	arg1	behavior					540:547	the adsorption behavior	525:547	the adsorption behavior	525:547	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior was investigated.
33892041	6	49	theme	MCP	991:993	arg1	behavior					979:986	the adsorption behavior	964:986	the adsorption behavior of MCP for Hg(II) ion	964:1008	The kinetics followed the pseudo-second-order, which indicated that the adsorption behavior of MCP for Hg(II) ion belonged to the chemical adsorption process and external diffusion.
33892041	0	50	theme	Hg	36:37	arg1	ions					43:46	Hg(II) ions	36:46	Hg(II) ions	36:46	Rapid and high selective removal of Hg(II) ions using tannic acid cross-linking cellulose/polyethyleneimine functionalized magnetic composite.
33892041	5	51	theme	adsorption	815:824	arg1	value					808:812	the pH value	801:812	the pH value	801:812	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	5	51	theme	adsorption	815:824	arg1	time					826:829	adsorption time	815:829	adsorption time	815:829	The corresponding adsorption capacity and removal rate of could reach 99.00% and 247.51 mg/g when the pH value, adsorption time, Hg(II) ion concentration were 5, 180 min and 100 mg/L at 293 K.
33892041	9	52	from	wastewater	1431:1440	arg1	applications					1413:1424	industry-level applications	1398:1424	industry-level applications from wastewater with Hg(II) ions	1398:1457	All in all, MCP with highly stable and efficient, as well as excellent reusability will be a candidate for industry-level applications from wastewater with Hg(II) ions.
33892041	3	53	theme	adsorption	529:538	arg1	behavior					540:547	the adsorption behavior	525:547	the adsorption behavior	525:547	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior was investigated.
33892041	8	54	theme	better	1242:1247	arg1	performance					1260:1270	better adsorption performance	1242:1270	better adsorption performance	1242:1270	After the fifth adsorption-desorption experiment, it still had better adsorption performance and reutilization.
33892041	3	55	theme	different	417:425	arg1	time					455:458	contact time	447:458	contact time	447:458	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior was investigated.
33892041	3	55	theme	different	417:425	arg1	temperature					510:520	adsorption temperature	499:520	adsorption temperature	499:520	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior was investigated.
33892041	3	55	theme	different	417:425	arg1	factors					427:433	the different factors	413:433	the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature	413:520	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior was investigated.
33892041	3	55	theme	different	417:425	arg1	pH					443:444	pH	443:444	pH	443:444	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior was investigated.
33892041	3	55	theme	different	417:425	arg1	concentration					480:492	initial Hg(II) ion concentration	461:492	initial Hg(II) ion concentration	461:492	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior was investigated.
33892041	6	56	theme	adsorption	968:977	arg1	behavior					979:986	the adsorption behavior	964:986	the adsorption behavior of MCP for Hg(II) ion	964:1008	The kinetics followed the pseudo-second-order, which indicated that the adsorption behavior of MCP for Hg(II) ion belonged to the chemical adsorption process and external diffusion.
33892041	4	57	theme	adsorption	682:691	arg1	capacity					693:700	very high adsorption capacity	672:700	very high adsorption capacity	672:700	The results showed that MCP exhibited an excellent selectivity and reutilization, fast removal rate, and very high adsorption capacity.
33892041	4	58	theme	high	677:680	arg1	capacity					693:700	very high adsorption capacity	672:700	very high adsorption capacity	672:700	The results showed that MCP exhibited an excellent selectivity and reutilization, fast removal rate, and very high adsorption capacity.
33892041	3	59	theme	factors	427:433	arg1	effect					403:408	The effect	399:408	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior	399:547	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior was investigated.
33892041	4	60	theme	fast	649:652	arg1	rate					662:665	fast removal rate	649:665	fast removal rate	649:665	The results showed that MCP exhibited an excellent selectivity and reutilization, fast removal rate, and very high adsorption capacity.
33892041	9	61	theme	efficient	1330:1338	arg1	reusability					1362:1372	highly stable and efficient, as well as excellent reusability	1312:1372	highly stable and efficient, as well as excellent reusability	1312:1372	All in all, MCP with highly stable and efficient, as well as excellent reusability will be a candidate for industry-level applications from wastewater with Hg(II) ions.
33892041	6	62	theme	chemical	1026:1033	arg1	process					1046:1052	the chemical adsorption process	1022:1052	the chemical adsorption process	1022:1052	The kinetics followed the pseudo-second-order, which indicated that the adsorption behavior of MCP for Hg(II) ion belonged to the chemical adsorption process and external diffusion.
33892041	7	63	theme	spontaneous	1143:1153	arg1	process					1170:1176	a spontaneous and exothermic process	1141:1176	a spontaneous and exothermic process	1141:1176	The thermodynamic study showed that the adsorption process was a spontaneous and exothermic process.
33892041	7	63	theme	spontaneous	1143:1153	arg1	process					1129:1135	the adsorption process	1114:1135	the adsorption process	1114:1135	The thermodynamic study showed that the adsorption process was a spontaneous and exothermic process.
33892041	3	64	theme	contact	447:453	arg1	time					455:458	contact time	447:458	contact time	447:458	The effect of the different factors such as pH, contact time, initial Hg(II) ion concentration, and adsorption temperature on the adsorption behavior was investigated.
33892041	9	65	theme	Hg	1447:1448	arg1	ions					1454:1457	Hg(II) ions	1447:1457	Hg(II) ions	1447:1457	All in all, MCP with highly stable and efficient, as well as excellent reusability will be a candidate for industry-level applications from wastewater with Hg(II) ions.
33892041	8	66	contain	had	1238:1240	arg1	it					1229:1230	it	1229:1230	it	1229:1230	After the fifth adsorption-desorption experiment, it still had better adsorption performance and reutilization.
33892041	8	66	contain	had	1238:1240	arg2	reutilization					1276:1288	reutilization	1276:1288	reutilization	1276:1288	After the fifth adsorption-desorption experiment, it still had better adsorption performance and reutilization.
33892041	8	66	contain	had	1238:1240	arg2	performance					1260:1270	better adsorption performance	1242:1270	better adsorption performance	1242:1270	After the fifth adsorption-desorption experiment, it still had better adsorption performance and reutilization.
33892041	2	67	theme	MCP	342:344	arg1	morphology					314:323	morphology	314:323	morphology	314:323	The morphology and structure of MCP were characterized with FT-IR, TG, XRD, SEM and TEM.
33892041	2	67	theme	MCP	342:344	arg1	structure					329:337	structure	329:337	structure	329:337	The morphology and structure of MCP were characterized with FT-IR, TG, XRD, SEM and TEM.
33087105	0	0	theme	zinc	75:78	arg1	oxide					80:84	zinc oxide	75:84	zinc oxide	75:84	Preparation and of PVA-based compositions with embedded silver, copper and zinc oxide nanoparticles and assessment of their antibacterial properties.
33087105	2	1	theme	other	326:330	arg1	components					360:369	other consistency-forming organic components	326:369	other consistency-forming organic components	326:369	The compositions also contained other consistency-forming organic components.
33087105	7	2	theme	oxide	703:707	arg1	incorporation					675:687	the incorporation	671:687	the incorporation of both metal oxide and metallic nanoparticles	671:734	Thanks to the incorporation of both metal oxide and metallic nanoparticles, it was possible to enrich the products with antibacterial properties.
33087105	7	3	with	products	767:774	arg1	properties					795:804	antibacterial properties	781:804	antibacterial properties	781:804	Thanks to the incorporation of both metal oxide and metallic nanoparticles, it was possible to enrich the products with antibacterial properties.
33087105	1	4	theme	zinc	231:234	arg1	oxide					236:240	zinc oxide	231:240	zinc oxide	231:240	A series of poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles has been prepared.
33087105	2	5	contain	contained	316:324	arg1	compositions					298:309	The compositions	294:309	The compositions	294:309	The compositions also contained other consistency-forming organic components.
33087105	2	5	contain	contained	316:324	arg2	components					360:369	other consistency-forming organic components	326:369	other consistency-forming organic components	326:369	The compositions also contained other consistency-forming organic components.
33087105	8	6	theme	microorganisms	852:865	arg1	growth					842:847	the growth	838:847	the growth of microorganisms	838:865	Their inhibiting properties in the growth of microorganisms have been confirmed against both Gram-negative and Gram-positive strains such as E. coli, S. aureus and P. aeruginosa.
33087105	1	7	theme	oxide	236:240	arg1	addition					219:226	addition	219:226	addition of zinc oxide	219:240	A series of poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles has been prepared.
33087105	1	8	theme	poly	162:165	arg1	nanoparticles					261:273	poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles	162:273	poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles	162:273	A series of poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles has been prepared.
33087105	7	9	theme	metal	697:701	arg1	oxide					703:707	metal oxide	697:707	metal oxide	697:707	Thanks to the incorporation of both metal oxide and metallic nanoparticles, it was possible to enrich the products with antibacterial properties.
33087105	5	10	theme	dynamic	545:551	arg1	scattering					559:568	a dynamic light scattering	543:568	a dynamic light scattering technique	543:578	Also, the size of nanoparticles has been defined with using a dynamic light scattering technique.
33087105	5	11	theme	light	553:557	arg1	scattering					559:568	a dynamic light scattering	543:568	a dynamic light scattering technique	543:578	Also, the size of nanoparticles has been defined with using a dynamic light scattering technique.
33087105	1	12	theme	vinyl	167:171	arg1	poly					162:165	poly	162:165	poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide	162:240	A series of poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles has been prepared.
33087105	1	12	theme	vinyl	167:171	arg1	alcohol					173:179	vinyl alcohol	167:179	vinyl alcohol	167:179	A series of poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles has been prepared.
33087105	3	13	theme	physico-chemical	376:391	arg1	properties					393:402	The physico-chemical properties	372:402	The physico-chemical properties of the products	372:418	The physico-chemical properties of the products have been determined.
33087105	5	14	theme	scattering	559:568	arg1	technique					570:578	a dynamic light scattering technique	543:578	a dynamic light scattering technique	543:578	Also, the size of nanoparticles has been defined with using a dynamic light scattering technique.
33087105	0	15	theme	PVA-based	19:27	arg1	compositions					29:40	PVA-based compositions	19:40	PVA-based compositions	19:40	Preparation and of PVA-based compositions with embedded silver, copper and zinc oxide nanoparticles and assessment of their antibacterial properties.
33087105	1	16	theme	silver	243:248	arg1	nanoparticles					261:273	poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles	162:273	poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles	162:273	A series of poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles has been prepared.
33087105	9	17	theme	contaminated	1077:1088	arg1	surface					1090:1096	a bacterially contaminated surface	1063:1096	a bacterially contaminated surface	1063:1096	Thanks to the ability for solidification, the compositions may be applied on a bacterially contaminated surface, and after destroying the microorganisms and its solidification, it may be peeled off along with the dead bacterial film.
33087105	8	18	from	properties	824:833	arg1	growth					842:847	the growth	838:847	the growth of microorganisms	838:865	Their inhibiting properties in the growth of microorganisms have been confirmed against both Gram-negative and Gram-positive strains such as E. coli, S. aureus and P. aeruginosa.
33087105	8	19	theme	Gram-negative	900:912	arg1	strains					932:938	both Gram-negative and Gram-positive strains	895:938	both Gram-negative and Gram-positive strains such as E. coli, S. aureus and P. aeruginosa	895:983	Their inhibiting properties in the growth of microorganisms have been confirmed against both Gram-negative and Gram-positive strains such as E. coli, S. aureus and P. aeruginosa.
33087105	8	19	theme	Gram-negative	900:912	arg1	coli					951:954	E. coli	948:954	E. coli	948:954	Their inhibiting properties in the growth of microorganisms have been confirmed against both Gram-negative and Gram-positive strains such as E. coli, S. aureus and P. aeruginosa.
33087105	8	19	theme	Gram-negative	900:912	arg1	aureus					960:965	S. aureus	957:965	S. aureus	957:965	Their inhibiting properties in the growth of microorganisms have been confirmed against both Gram-negative and Gram-positive strains such as E. coli, S. aureus and P. aeruginosa.
33087105	8	19	theme	Gram-negative	900:912	arg1	aeruginosa					974:983	P. aeruginosa	971:983	P. aeruginosa	971:983	Their inhibiting properties in the growth of microorganisms have been confirmed against both Gram-negative and Gram-positive strains such as E. coli, S. aureus and P. aeruginosa.
33087105	1	20	theme	copper	254:259	arg1	nanoparticles					261:273	poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles	162:273	poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles	162:273	A series of poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles has been prepared.
33087105	0	21	theme	properties	138:147	arg1	assessment					104:113	and assessment	100:113	assessment	104:113	Preparation and of PVA-based compositions with embedded silver, copper and zinc oxide nanoparticles and assessment of their antibacterial properties.
33087105	9	22	theme	dead	1199:1202	arg1	film					1214:1217	the dead bacterial film	1195:1217	the dead bacterial film	1195:1217	Thanks to the ability for solidification, the compositions may be applied on a bacterially contaminated surface, and after destroying the microorganisms and its solidification, it may be peeled off along with the dead bacterial film.
33087105	0	23	theme	compositions	29:40	arg1	Preparation					0:10	Preparation	0:10	Preparation and of PVA-based compositions with embedded silver, copper and zinc oxide	0:84	Preparation and of PVA-based compositions with embedded silver, copper and zinc oxide nanoparticles and assessment of their antibacterial properties.
33087105	1	24	theme	nanoparticles	261:273	arg1	series					152:157	A series	150:157	A series of poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles	150:273	A series of poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles has been prepared.
33087105	0	25	theme	antibacterial	124:136	arg1	properties					138:147	their antibacterial properties	118:147	their antibacterial properties	118:147	Preparation and of PVA-based compositions with embedded silver, copper and zinc oxide nanoparticles and assessment of their antibacterial properties.
33087105	9	26	theme	bacterial	1204:1212	arg1	film					1214:1217	the dead bacterial film	1195:1217	the dead bacterial film	1195:1217	Thanks to the ability for solidification, the compositions may be applied on a bacterially contaminated surface, and after destroying the microorganisms and its solidification, it may be peeled off along with the dead bacterial film.
33087105	8	27	theme	Gram-positive	918:930	arg1	strains					932:938	both Gram-negative and Gram-positive strains	895:938	both Gram-negative and Gram-positive strains such as E. coli, S. aureus and P. aeruginosa	895:983	Their inhibiting properties in the growth of microorganisms have been confirmed against both Gram-negative and Gram-positive strains such as E. coli, S. aureus and P. aeruginosa.
33087105	8	27	theme	Gram-positive	918:930	arg1	coli					951:954	E. coli	948:954	E. coli	948:954	Their inhibiting properties in the growth of microorganisms have been confirmed against both Gram-negative and Gram-positive strains such as E. coli, S. aureus and P. aeruginosa.
33087105	8	27	theme	Gram-positive	918:930	arg1	aureus					960:965	S. aureus	957:965	S. aureus	957:965	Their inhibiting properties in the growth of microorganisms have been confirmed against both Gram-negative and Gram-positive strains such as E. coli, S. aureus and P. aeruginosa.
33087105	8	27	theme	Gram-positive	918:930	arg1	aeruginosa					974:983	P. aeruginosa	971:983	P. aeruginosa	971:983	Their inhibiting properties in the growth of microorganisms have been confirmed against both Gram-negative and Gram-positive strains such as E. coli, S. aureus and P. aeruginosa.
33087105	7	28	theme	antibacterial	781:793	arg1	properties					795:804	antibacterial properties	781:804	antibacterial properties	781:804	Thanks to the incorporation of both metal oxide and metallic nanoparticles, it was possible to enrich the products with antibacterial properties.
33087105	0	29	theme	embedded	47:54	arg1	silver					56:61	embedded silver	47:61	embedded silver	47:61	Preparation and of PVA-based compositions with embedded silver, copper and zinc oxide nanoparticles and assessment of their antibacterial properties.
33087105	0	30	with	Preparation	0:10	arg1	copper					64:69	copper	64:69	copper	64:69	Preparation and of PVA-based compositions with embedded silver, copper and zinc oxide nanoparticles and assessment of their antibacterial properties.
33087105	0	30	with	Preparation	0:10	arg1	oxide					80:84	zinc oxide	75:84	zinc oxide	75:84	Preparation and of PVA-based compositions with embedded silver, copper and zinc oxide nanoparticles and assessment of their antibacterial properties.
33087105	0	30	with	Preparation	0:10	arg1	silver					56:61	embedded silver	47:61	embedded silver	47:61	Preparation and of PVA-based compositions with embedded silver, copper and zinc oxide nanoparticles and assessment of their antibacterial properties.
33087105	6	31	theme	microscopic	631:641	arg1	analysis					643:650	microscopic analysis	631:650	microscopic analysis	631:650	The compositions were subjected to XRD, FT-IR and microscopic analysis as well.
33087105	8	32	theme	inhibiting	813:822	arg1	properties					824:833	Their inhibiting properties	807:833	Their inhibiting properties in the growth of microorganisms	807:865	Their inhibiting properties in the growth of microorganisms have been confirmed against both Gram-negative and Gram-positive strains such as E. coli, S. aureus and P. aeruginosa.
33087105	1	33	theme	liquid	194:199	arg1	compositions					201:212	liquid compositions	194:212	liquid compositions	194:212	A series of poly(vinyl alcohol) (PVA) based liquid compositions with addition of zinc oxide, silver and copper nanoparticles has been prepared.
33087105	5	34	theme	nanoparticles	501:513	arg1	size					493:496	the size	489:496	the size of nanoparticles	489:513	Also, the size of nanoparticles has been defined with using a dynamic light scattering technique.
33087105	2	35	theme	organic	352:358	arg1	components					360:369	other consistency-forming organic components	326:369	other consistency-forming organic components	326:369	The compositions also contained other consistency-forming organic components.
33087105	7	36	theme	metallic	713:720	arg1	nanoparticles					722:734	metallic nanoparticles	713:734	metallic nanoparticles	713:734	Thanks to the incorporation of both metal oxide and metallic nanoparticles, it was possible to enrich the products with antibacterial properties.
33087105	3	37	theme	products	411:418	arg1	properties					393:402	The physico-chemical properties	372:402	The physico-chemical properties of the products	372:418	The physico-chemical properties of the products have been determined.
33087105	2	38	theme	consistency-forming	332:350	arg1	components					360:369	other consistency-forming organic components	326:369	other consistency-forming organic components	326:369	The compositions also contained other consistency-forming organic components.
33087105	7	39	theme	nanoparticles	722:734	arg1	incorporation					675:687	the incorporation	671:687	the incorporation of both metal oxide and metallic nanoparticles	671:734	Thanks to the incorporation of both metal oxide and metallic nanoparticles, it was possible to enrich the products with antibacterial properties.
34555709	3	0	theme	hydrophobic	505:515	arg1	nature					517:522	the hydrophobic nature	501:522	the hydrophobic nature of curcumin	501:534	Results showed that inclusion of the curcumin-loaded nanoemulsions reduced water vapor permeability, given the hydrophobic nature of curcumin.
34555709	0	1	theme	curcumin-loaded	63:77	arg1	nanoemulsions					79:91	banana starch and curcumin-loaded nanoemulsions	45:91	banana starch and curcumin-loaded nanoemulsions	45:91	Development of active edible films made from banana starch and curcumin-loaded nanoemulsions.
34555709	6	2	theme	aqueous	816:822	arg1	simulants					845:853	both aqueous and non-aqueous food simulants	811:853	both aqueous and non-aqueous food simulants	811:853	Results showed that curcumin release is diffusion driven in both aqueous and non-aqueous food simulants, however it seems that while the complete nanoemulsion droplets are released in the aqueous simulant, in non-aqueous simulant only curcumin molecules are released.
34555709	2	3	theme	banana	321:326	arg1	starch					328:333	banana starch	321:333	banana starch incorporated with curcumin-loaded orange oil nanoemulsion	321:391	This paper presents the development of an active film made from banana starch incorporated with curcumin-loaded orange oil nanoemulsion.
34555709	5	4	from	film	715:718	arg1	profiles					678:685	the release profiles	666:685	the release profiles of curcumin from the active film into different food simulants	666:748	Finally, this paper reports the release profiles of curcumin from the active film into different food simulants.
34555709	6	5	theme	nanoemulsion	897:908	arg1	droplets					910:917	the complete nanoemulsion droplets	884:917	the complete nanoemulsion droplets	884:917	Results showed that curcumin release is diffusion driven in both aqueous and non-aqueous food simulants, however it seems that while the complete nanoemulsion droplets are released in the aqueous simulant, in non-aqueous simulant only curcumin molecules are released.
34555709	1	6	dep	used	123:126	arg1	products					161:168	food products	156:168	food products	156:168	Active packaging that can be used to release active molecules food products during storage has been a central part in food science research over the last decades.
34555709	1	7	theme	last	243:246	arg1	decades					248:254	the last decades	239:254	the last decades	239:254	Active packaging that can be used to release active molecules food products during storage has been a central part in food science research over the last decades.
34555709	5	8	theme	different	725:733	arg1	simulants					740:748	different food simulants	725:748	different food simulants	725:748	Finally, this paper reports the release profiles of curcumin from the active film into different food simulants.
34555709	6	9	theme	complete	888:895	arg1	droplets					910:917	the complete nanoemulsion droplets	884:917	the complete nanoemulsion droplets	884:917	Results showed that curcumin release is diffusion driven in both aqueous and non-aqueous food simulants, however it seems that while the complete nanoemulsion droplets are released in the aqueous simulant, in non-aqueous simulant only curcumin molecules are released.
34555709	6	10	theme	only	981:984	arg1	molecules					995:1003	in non-aqueous simulant only curcumin molecules	957:1003	in non-aqueous simulant only curcumin molecules	957:1003	Results showed that curcumin release is diffusion driven in both aqueous and non-aqueous food simulants, however it seems that while the complete nanoemulsion droplets are released in the aqueous simulant, in non-aqueous simulant only curcumin molecules are released.
34555709	5	11	theme	food	735:738	arg1	simulants					740:748	different food simulants	725:748	different food simulants	725:748	Finally, this paper reports the release profiles of curcumin from the active film into different food simulants.
34555709	4	12	theme	nanoemulsion	624:635	arg1	effect					610:615	the plasticizing effect	593:615	the plasticizing effect of the nanoemulsion	593:635	Likewise, elongation at break was also increased due to the plasticizing effect of the nanoemulsion.
34555709	4	13	theme	plasticizing	597:608	arg1	effect					610:615	the plasticizing effect	593:615	the plasticizing effect of the nanoemulsion	593:635	Likewise, elongation at break was also increased due to the plasticizing effect of the nanoemulsion.
34555709	2	14	theme	oil	376:378	arg1	nanoemulsion					380:391	curcumin-loaded orange oil nanoemulsion	353:391	curcumin-loaded orange oil nanoemulsion	353:391	This paper presents the development of an active film made from banana starch incorporated with curcumin-loaded orange oil nanoemulsion.
34555709	3	15	theme	curcumin	527:534	arg1	nature					517:522	the hydrophobic nature	501:522	the hydrophobic nature of curcumin	501:534	Results showed that inclusion of the curcumin-loaded nanoemulsions reduced water vapor permeability, given the hydrophobic nature of curcumin.
34555709	2	16	theme	orange	369:374	arg1	nanoemulsion					380:391	curcumin-loaded orange oil nanoemulsion	353:391	curcumin-loaded orange oil nanoemulsion	353:391	This paper presents the development of an active film made from banana starch incorporated with curcumin-loaded orange oil nanoemulsion.
34555709	6	17	theme	simulant	972:979	arg1	molecules					995:1003	in non-aqueous simulant only curcumin molecules	957:1003	in non-aqueous simulant only curcumin molecules	957:1003	Results showed that curcumin release is diffusion driven in both aqueous and non-aqueous food simulants, however it seems that while the complete nanoemulsion droplets are released in the aqueous simulant, in non-aqueous simulant only curcumin molecules are released.
34555709	1	18	theme	Active	94:99	arg1	packaging					101:109	Active packaging	94:109	Active packaging that can be used to release active molecules food products during storage	94:183	Active packaging that can be used to release active molecules food products during storage has been a central part in food science research over the last decades.
34555709	1	18	theme	Active	94:99	arg1	part					204:207	a central part	194:207	a central part in food science research	194:232	Active packaging that can be used to release active molecules food products during storage has been a central part in food science research over the last decades.
34555709	2	19	theme	curcumin-loaded	353:367	arg1	nanoemulsion					380:391	curcumin-loaded orange oil nanoemulsion	353:391	curcumin-loaded orange oil nanoemulsion	353:391	This paper presents the development of an active film made from banana starch incorporated with curcumin-loaded orange oil nanoemulsion.
34555709	0	20	theme	edible	22:27	arg1	films					29:33	active edible films	15:33	active edible films	15:33	Development of active edible films made from banana starch and curcumin-loaded nanoemulsions.
34555709	6	21	theme	non-aqueous	960:970	arg1	molecules					995:1003	in non-aqueous simulant only curcumin molecules	957:1003	in non-aqueous simulant only curcumin molecules	957:1003	Results showed that curcumin release is diffusion driven in both aqueous and non-aqueous food simulants, however it seems that while the complete nanoemulsion droplets are released in the aqueous simulant, in non-aqueous simulant only curcumin molecules are released.
34555709	6	22	theme	curcumin	771:778	arg1	release					780:786	curcumin release	771:786	curcumin release	771:786	Results showed that curcumin release is diffusion driven in both aqueous and non-aqueous food simulants, however it seems that while the complete nanoemulsion droplets are released in the aqueous simulant, in non-aqueous simulant only curcumin molecules are released.
34555709	3	23	theme	water	469:473	arg1	permeability					481:492	water vapor permeability	469:492	water vapor permeability	469:492	Results showed that inclusion of the curcumin-loaded nanoemulsions reduced water vapor permeability, given the hydrophobic nature of curcumin.
34555709	1	24	used	used	123:126	arg2	part					204:207	a central part	194:207	a central part in food science research	194:232	Active packaging that can be used to release active molecules food products during storage has been a central part in food science research over the last decades.
34555709	1	24	used	used	123:126	arg2	packaging					101:109	Active packaging	94:109	Active packaging that can be used to release active molecules food products during storage	94:183	Active packaging that can be used to release active molecules food products during storage has been a central part in food science research over the last decades.
34555709	6	25	theme	in	957:958	arg1	molecules					995:1003	in non-aqueous simulant only curcumin molecules	957:1003	in non-aqueous simulant only curcumin molecules	957:1003	Results showed that curcumin release is diffusion driven in both aqueous and non-aqueous food simulants, however it seems that while the complete nanoemulsion droplets are released in the aqueous simulant, in non-aqueous simulant only curcumin molecules are released.
34555709	1	26	theme	food	156:159	arg1	products					161:168	food products	156:168	food products	156:168	Active packaging that can be used to release active molecules food products during storage has been a central part in food science research over the last decades.
34555709	3	27	theme	vapor	475:479	arg1	permeability					481:492	water vapor permeability	469:492	water vapor permeability	469:492	Results showed that inclusion of the curcumin-loaded nanoemulsions reduced water vapor permeability, given the hydrophobic nature of curcumin.
34555709	5	28	theme	active	708:713	arg1	film					715:718	the active film	704:718	the active film into different food simulants	704:748	Finally, this paper reports the release profiles of curcumin from the active film into different food simulants.
34555709	3	29	theme	nanoemulsions	447:459	arg1	inclusion					414:422	inclusion	414:422	inclusion of the curcumin-loaded nanoemulsions	414:459	Results showed that inclusion of the curcumin-loaded nanoemulsions reduced water vapor permeability, given the hydrophobic nature of curcumin.
34555709	1	30	theme	central	196:202	arg1	packaging					101:109	Active packaging	94:109	Active packaging that can be used to release active molecules food products during storage	94:183	Active packaging that can be used to release active molecules food products during storage has been a central part in food science research over the last decades.
34555709	1	30	theme	central	196:202	arg1	part					204:207	a central part	194:207	a central part in food science research	194:232	Active packaging that can be used to release active molecules food products during storage has been a central part in food science research over the last decades.
34555709	0	31	theme	films	29:33	arg1	Development					0:10	Development	0:10	Development of active edible films	0:33	Development of active edible films made from banana starch and curcumin-loaded nanoemulsions.
34555709	4	32	from	break	561:565	arg1	elongation					547:556	elongation	547:556	elongation at break	547:565	Likewise, elongation at break was also increased due to the plasticizing effect of the nanoemulsion.
34555709	0	33	theme	banana	45:50	arg1	nanoemulsions					79:91	banana starch and curcumin-loaded nanoemulsions	45:91	banana starch and curcumin-loaded nanoemulsions	45:91	Development of active edible films made from banana starch and curcumin-loaded nanoemulsions.
34555709	6	34	theme	aqueous	939:945	arg1	simulant					947:954	the aqueous simulant	935:954	the aqueous simulant	935:954	Results showed that curcumin release is diffusion driven in both aqueous and non-aqueous food simulants, however it seems that while the complete nanoemulsion droplets are released in the aqueous simulant, in non-aqueous simulant only curcumin molecules are released.
34555709	5	35	theme	release	670:676	arg1	profiles					678:685	the release profiles	666:685	the release profiles of curcumin from the active film into different food simulants	666:748	Finally, this paper reports the release profiles of curcumin from the active film into different food simulants.
34555709	1	36	from	part	204:207	arg1	research					225:232	food science research	212:232	food science research	212:232	Active packaging that can be used to release active molecules food products during storage has been a central part in food science research over the last decades.
34555709	6	37	theme	food	840:843	arg1	simulants					845:853	both aqueous and non-aqueous food simulants	811:853	both aqueous and non-aqueous food simulants	811:853	Results showed that curcumin release is diffusion driven in both aqueous and non-aqueous food simulants, however it seems that while the complete nanoemulsion droplets are released in the aqueous simulant, in non-aqueous simulant only curcumin molecules are released.
34555709	2	38	theme	film	306:309	arg1	development					281:291	the development	277:291	the development of an active film made from banana starch incorporated with curcumin-loaded orange oil nanoemulsion	277:391	This paper presents the development of an active film made from banana starch incorporated with curcumin-loaded orange oil nanoemulsion.
34555709	6	39	theme	curcumin	986:993	arg1	molecules					995:1003	in non-aqueous simulant only curcumin molecules	957:1003	in non-aqueous simulant only curcumin molecules	957:1003	Results showed that curcumin release is diffusion driven in both aqueous and non-aqueous food simulants, however it seems that while the complete nanoemulsion droplets are released in the aqueous simulant, in non-aqueous simulant only curcumin molecules are released.
34555709	5	40	theme	curcumin	690:697	arg1	profiles					678:685	the release profiles	666:685	the release profiles of curcumin from the active film into different food simulants	666:748	Finally, this paper reports the release profiles of curcumin from the active film into different food simulants.
34555709	6	41	theme	non-aqueous	828:838	arg1	simulants					845:853	both aqueous and non-aqueous food simulants	811:853	both aqueous and non-aqueous food simulants	811:853	Results showed that curcumin release is diffusion driven in both aqueous and non-aqueous food simulants, however it seems that while the complete nanoemulsion droplets are released in the aqueous simulant, in non-aqueous simulant only curcumin molecules are released.
34555709	2	42	theme	active	299:304	arg1	film					306:309	an active film	296:309	an active film made from banana starch incorporated with curcumin-loaded orange oil nanoemulsion	296:391	This paper presents the development of an active film made from banana starch incorporated with curcumin-loaded orange oil nanoemulsion.
34555709	1	43	theme	food	212:215	arg1	research					225:232	food science research	212:232	food science research	212:232	Active packaging that can be used to release active molecules food products during storage has been a central part in food science research over the last decades.
34555709	3	44	theme	curcumin-loaded	431:445	arg1	nanoemulsions					447:459	the curcumin-loaded nanoemulsions	427:459	the curcumin-loaded nanoemulsions	427:459	Results showed that inclusion of the curcumin-loaded nanoemulsions reduced water vapor permeability, given the hydrophobic nature of curcumin.
34555709	1	45	theme	science	217:223	arg1	research					225:232	food science research	212:232	food science research	212:232	Active packaging that can be used to release active molecules food products during storage has been a central part in food science research over the last decades.
34555709	0	46	theme	starch	52:57	arg1	nanoemulsions					79:91	banana starch and curcumin-loaded nanoemulsions	45:91	banana starch and curcumin-loaded nanoemulsions	45:91	Development of active edible films made from banana starch and curcumin-loaded nanoemulsions.
34555709	0	47	theme	active	15:20	arg1	films					29:33	active edible films	15:33	active edible films	15:33	Development of active edible films made from banana starch and curcumin-loaded nanoemulsions.
34555709	1	48	theme	active	139:144	arg1	molecules					146:154	active molecules	139:154	active molecules	139:154	Active packaging that can be used to release active molecules food products during storage has been a central part in food science research over the last decades.
33859330	3	0	from	females	684:690	arg1	indices					639:645	multiple indices	630:645	multiple indices of mood and well-being in 64 healthy females	630:690	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	4	1	theme	GOS	924:926	arg1	intervention					928:939	the GOS intervention	920:939	the GOS intervention	920:939	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	5	2	theme	Gut	1127:1129	arg1	research					1142:1149	Gut microbiota research	1127:1149	Gut microbiota research	1127:1149	Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans.
33859330	2	3	theme	nutritional	492:502	arg1	supplementation					504:518	nutritional supplementation	492:518	nutritional supplementation to influence the gut microbiota	492:550	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	0	4	from	effects	11:17	arg1	18-25 years					79:89	18-25 years	79:89	18-25 years	79:89	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.
33859330	0	4	from	effects	11:17	arg1	females					70:76	healthy females	62:76	healthy females (18-25 years) with corresponding changes in gut bacterial composition	62:146	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.
33859330	6	5	theme	important	1349:1357	arg1	contribution					1359:1370	an important contribution	1346:1370	an important contribution to this effort	1346:1385	Our work makes an important contribution to this effort by combining a psychobiotic intervention in a human sample with comprehensive behavioural and gut microbiota measures.
33859330	1	6	theme	pre-	177:180	arg1	supplementation					196:210	pre- and probiotic supplementation	177:210	pre- and probiotic supplementation	177:210	Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike.
33859330	1	6	theme	pre-	177:180	arg1	tool					227:230	a potential tool	215:230	a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike	215:362	Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike.
33859330	1	7	theme	mental	275:280	arg1	ailments					282:289	physical and mental ailments	262:289	physical and mental ailments	262:289	Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike.
33859330	0	8	theme	corresponding	97:109	arg1	changes					111:117	corresponding changes	97:117	corresponding changes in gut bacterial composition	97:146	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.
33859330	3	9	theme	4-week	697:702	arg1	intervention					789:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	3	9	theme	4-week	697:702	arg1	blind					711:715	a 4-week double blind	695:715	a 4-week double blind	695:715	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	6	10	theme	psychobiotic	1402:1413	arg1	intervention					1415:1426	a psychobiotic intervention	1400:1426	a psychobiotic intervention in a human sample	1400:1444	Our work makes an important contribution to this effort by combining a psychobiotic intervention in a human sample with comprehensive behavioural and gut microbiota measures.
33859330	4	11	theme	bacterial	1000:1008	arg1	abundance					1010:1018	bacterial abundance	1000:1018	bacterial abundance	1000:1018	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	3	12	theme	controlled	726:735	arg1	intervention					789:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	3	12	theme	controlled	726:735	arg1	blind					711:715	a 4-week double blind	695:715	a 4-week double blind	695:715	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	2	13	theme	later	606:610	arg1	life					612:615	later life	606:615	later life	606:615	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	2	14	contain	have	553:556	arg1	supplementation					504:518	nutritional supplementation	492:518	nutritional supplementation to influence the gut microbiota	492:550	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	2	14	contain	have	553:556	arg1	interventions					469:481	effective interventions	459:481	effective interventions	459:481	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	2	14	contain	have	553:556	arg2	potential					562:570	the potential to offset health-related costs in later life	558:615	the potential to offset health-related costs in later life	558:615	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	2	15	theme	gut	537:539	arg1	microbiota					541:550	the gut microbiota	533:550	the gut microbiota	533:550	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	3	16	theme	galacto-oligosaccharides	737:760	arg1	intervention					789:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	3	16	theme	galacto-oligosaccharides	737:760	arg1	blind					711:715	a 4-week double blind	695:715	a 4-week double blind	695:715	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	0	17	with	females	70:76	arg1	changes					111:117	corresponding changes	97:117	corresponding changes in gut bacterial composition	97:146	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.
33859330	4	18	theme	attentional	978:988	arg1	bias					990:993	attentional bias	978:993	attentional bias	978:993	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	3	19	from	well-being	659:668	arg1	females					684:690	64 healthy females	673:690	64 healthy females	673:690	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	3	20	from	indices	639:645	arg1	females					684:690	64 healthy females	673:690	64 healthy females	673:690	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	1	21	theme	probiotic	186:194	arg1	supplementation					196:210	pre- and probiotic supplementation	177:210	pre- and probiotic supplementation	177:210	Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike.
33859330	1	21	theme	probiotic	186:194	arg1	tool					227:230	a potential tool	215:230	a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike	215:362	Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike.
33859330	2	22	theme	effective	459:467	arg1	supplementation					504:518	nutritional supplementation	492:518	nutritional supplementation to influence the gut microbiota	492:550	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	2	22	theme	effective	459:467	arg1	interventions					469:481	effective interventions	459:481	effective interventions	459:481	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	3	23	theme	placebo	718:724	arg1	intervention					789:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	3	23	theme	placebo	718:724	arg1	blind					711:715	a 4-week double blind	695:715	a 4-week double blind	695:715	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	5	24	theme	microbiota	1131:1140	arg1	research					1142:1149	Gut microbiota research	1127:1149	Gut microbiota research	1127:1149	Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans.
33859330	2	25	theme	transitional	386:397	arg1	period					399:404	the transitional period	382:404	the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life	382:615	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	0	26	theme	Anxiolytic	0:9	arg1	effects					11:17	Anxiolytic effects	0:17	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.	0:147	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.
33859330	5	27	theme	community	1206:1214	arg1	alike					1216:1220	the scientific and lay community alike	1183:1220	the scientific and lay community alike	1183:1220	Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans.
33859330	6	28	from	intervention	1415:1426	arg1	sample					1439:1444	a human sample	1431:1444	a human sample	1431:1444	Our work makes an important contribution to this effort by combining a psychobiotic intervention in a human sample with comprehensive behavioural and gut microbiota measures.
33859330	5	29	theme	rigorous	1302:1309	arg1	research					1311:1318	rigorous research	1302:1318	rigorous research in humans	1302:1328	Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans.
33859330	4	30	theme	GOS	1068:1070	arg1	prebiotic					1072:1080	a GOS prebiotic	1066:1080	a GOS prebiotic	1066:1080	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	3	31	theme	prebiotic	768:776	arg1	intervention					789:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	3	31	theme	prebiotic	768:776	arg1	blind					711:715	a 4-week double blind	695:715	a 4-week double blind	695:715	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	0	32	theme	bacterial	126:134	arg1	composition					136:146	gut bacterial composition	122:146	gut bacterial composition	122:146	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.
33859330	4	33	with	supplementation	1045:1059	arg1	prebiotic					1072:1080	a GOS prebiotic	1066:1080	a GOS prebiotic	1066:1080	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	2	34	theme	early	430:434	arg1	adulthood					436:444	early adulthood	430:444	early adulthood	430:444	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	2	35	theme	adulthood	436:444	arg1	period					399:404	the transitional period	382:404	the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life	382:615	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	0	36	theme	gut	122:124	arg1	composition					136:146	gut bacterial composition	122:146	gut bacterial composition	122:146	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.
33859330	3	37	theme	well-being	659:668	arg1	indices					639:645	multiple indices	630:645	multiple indices of mood and well-being in 64 healthy females	630:690	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	1	38	theme	potential	217:225	arg1	supplementation					196:210	pre- and probiotic supplementation	177:210	pre- and probiotic supplementation	177:210	Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike.
33859330	1	38	theme	potential	217:225	arg1	tool					227:230	a potential tool	215:230	a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike	215:362	Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike.
33859330	0	39	theme	prebiotic	49:57	arg1	effects					11:17	Anxiolytic effects	0:17	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.	0:147	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.
33859330	3	40	theme	GOS	763:765	arg1	intervention					789:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	3	40	theme	GOS	763:765	arg1	blind					711:715	a 4-week double blind	695:715	a 4-week double blind	695:715	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	4	41	theme	trait	963:967	arg1	anxiety					969:975	self-reported high trait anxiety	944:975	self-reported high trait anxiety	944:975	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	6	42	theme	microbiota	1485:1494	arg1	measures					1496:1503	microbiota measures	1485:1503	microbiota measures	1485:1503	Our work makes an important contribution to this effort by combining a psychobiotic intervention in a human sample with comprehensive behavioural and gut microbiota measures.
33859330	2	43	theme	adolescence	414:424	arg1	period					399:404	the transitional period	382:404	the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life	382:615	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	0	44	theme	galacto-oligosaccharides	24:47	arg1	prebiotic					49:57	a galacto-oligosaccharides prebiotic	22:57	a galacto-oligosaccharides prebiotic	22:57	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.
33859330	1	45	theme	attractive	310:319	arg1	concept					321:327	an attractive concept	307:327	an attractive concept for clinicians and consumers alike	307:362	Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike.
33859330	3	46	theme	gut	859:861	arg1	sequencing					874:883	gut microbiota sequencing	859:883	gut microbiota sequencing	859:883	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	3	47	theme	mood	650:653	arg1	indices					639:645	multiple indices	630:645	multiple indices of mood and well-being in 64 healthy females	630:690	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	6	48	theme	human	1433:1437	arg1	sample					1439:1444	a human sample	1431:1444	a human sample	1431:1444	Our work makes an important contribution to this effort by combining a psychobiotic intervention in a human sample with comprehensive behavioural and gut microbiota measures.
33859330	6	49	dep	behavioural	1465:1475	arg1	measures					1496:1503	microbiota measures	1485:1503	microbiota measures	1485:1503	Our work makes an important contribution to this effort by combining a psychobiotic intervention in a human sample with comprehensive behavioural and gut microbiota measures.
33859330	2	50	theme	late	409:412	arg1	adolescence					414:424	late adolescence	409:424	late adolescence	409:424	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	0	51	theme	healthy	62:68	arg1	18-25 years					79:89	18-25 years	79:89	18-25 years	79:89	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.
33859330	0	51	theme	healthy	62:68	arg1	females					70:76	healthy females	62:76	healthy females (18-25 years) with corresponding changes in gut bacterial composition	62:146	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.
33859330	3	52	from	mood	650:653	arg1	females					684:690	64 healthy females	673:690	64 healthy females	673:690	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	5	53	theme	alike	1216:1220	arg1	imagination					1168:1178	the imagination	1164:1178	the imagination of the scientific and lay community alike	1164:1220	Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans.
33859330	4	54	theme	intervention	928:939	arg1	effects					909:915	effects	909:915	effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance	909:1018	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	4	55	theme	high	958:961	arg1	anxiety					969:975	self-reported high trait anxiety	944:975	self-reported high trait anxiety	944:975	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	3	56	theme	supplement	778:787	arg1	intervention					789:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	3	56	theme	supplement	778:787	arg1	blind					711:715	a 4-week double blind	695:715	a 4-week double blind	695:715	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	4	57	theme	self-reported	944:956	arg1	anxiety					969:975	self-reported high trait anxiety	944:975	self-reported high trait anxiety	944:975	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	5	58	from	research	1311:1318	arg1	humans					1323:1328	humans	1323:1328	humans	1323:1328	Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans.
33859330	4	59	theme	pre-clinical	1105:1116	arg1	anxiety					1118:1124	pre-clinical anxiety	1105:1124	pre-clinical anxiety	1105:1124	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	5	60	theme	lay	1202:1204	arg1	alike					1216:1220	the scientific and lay community alike	1183:1220	the scientific and lay community alike	1183:1220	Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans.
33859330	2	61	theme	health-related	582:595	arg1	costs					597:601	health-related costs	582:601	health-related costs	582:601	Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life.
33859330	0	62	from	changes	111:117	arg1	composition					136:146	gut bacterial composition	122:146	gut bacterial composition	122:146	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition.
33859330	1	63	from	symptomology	246:257	arg1	ailments					282:289	physical and mental ailments	262:289	physical and mental ailments	262:289	Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike.
33859330	5	64	with	met	1293:1295	arg1	research					1311:1318	rigorous research	1302:1318	rigorous research in humans	1302:1328	Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans.
33859330	3	65	theme	microbiota	863:872	arg1	sequencing					874:883	gut microbiota sequencing	859:883	gut microbiota sequencing	859:883	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	4	66	from	effects	909:915	arg1	anxiety					969:975	self-reported high trait anxiety	944:975	self-reported high trait anxiety	944:975	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	4	66	from	effects	909:915	arg1	bias					990:993	attentional bias	978:993	attentional bias	978:993	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	4	66	from	effects	909:915	arg1	abundance					1010:1018	bacterial abundance	1000:1018	bacterial abundance	1000:1018	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	5	67	theme	scientific	1187:1196	arg1	alike					1216:1220	the scientific and lay community alike	1183:1220	the scientific and lay community alike	1183:1220	Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans.
33859330	3	68	theme	healthy	676:682	arg1	females					684:690	64 healthy females	673:690	64 healthy females	673:690	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	1	69	theme	Current	149:155	arg1	research					157:164	Current research	149:164	Current research	149:164	Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike.
33859330	4	70	theme	anxiety	1118:1124	arg1	indices					1094:1100	indices	1094:1100	indices of pre-clinical anxiety	1094:1124	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	3	71	theme	stool	815:819	arg1	samples					821:827	stool samples	815:827	stool samples	815:827	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	4	72	theme	dietary	1037:1043	arg1	supplementation					1045:1059	dietary supplementation	1037:1059	dietary supplementation with a GOS prebiotic	1037:1080	We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety.
33859330	3	73	theme	double	704:709	arg1	intervention					789:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention	718:800	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	3	73	theme	double	704:709	arg1	blind					711:715	a 4-week double blind	695:715	a 4-week double blind	695:715	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	3	74	theme	multiple	630:637	arg1	indices					639:645	multiple indices	630:645	multiple indices of mood and well-being in 64 healthy females	630:690	We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses.
33859330	5	75	theme	early	1260:1264	arg1	enthusiasm					1266:1275	this early enthusiasm	1255:1275	this early enthusiasm	1255:1275	Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans.
33859330	1	76	theme	physical	262:269	arg1	ailments					282:289	physical and mental ailments	262:289	physical and mental ailments	262:289	Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike.
33596707	8	0	dep	CaHPO4	1279:1284	arg1	rises					1286:1290	rises	1286:1290	rises	1286:1290	Additionally, as the proportion of CaCO3 in comparison with CaHPO4 rises, the mechanical properties improve.
33596707	9	1	theme	cell	1352:1355	arg1	proliferation					1357:1369	cell proliferation	1352:1369	cell proliferation	1352:1369	On the other hand, both cell proliferation and mineralization are improved with the addition of calcium minerals.
33596707	7	2	dep	higher	1116:1121	arg1	amount					1127:1132	the amount	1123:1132	the higher the amount of minerals	1112:1144	On the one hand, the higher the amount of minerals added to the composition, the better the mechanical properties obtained.
33596707	5	3	theme	minerals	953:960	arg1	%					936:936	20%	934:936	20%	934:936	Different proportions of calcium compounds (CaCO3 and CaHPO4) are used to make up between 20% and 30% of the minerals used in a mineral-hydrogel mix.
33596707	5	3	theme	minerals	953:960	arg1	%					944:944	30%	942:944	30%	942:944	Different proportions of calcium compounds (CaCO3 and CaHPO4) are used to make up between 20% and 30% of the minerals used in a mineral-hydrogel mix.
33596707	5	3	theme	minerals	953:960	arg1	minerals					953:960	the minerals	949:960	the minerals used in a mineral-hydrogel mix	949:991	Different proportions of calcium compounds (CaCO3 and CaHPO4) are used to make up between 20% and 30% of the minerals used in a mineral-hydrogel mix.
33596707	1	4	dep	advantages	279:288	arg1	biodegradability					377:392	biodegradability	377:392	biodegradability	377:392	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	1	4	dep	advantages	279:288	arg1	price					367:371	low price	363:371	low price	363:371	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	1	4	dep	advantages	279:288	arg1	advantages					279:288	their advantages	273:288	their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability	273:392	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	1	4	dep	advantages	279:288	arg1	biocompatibility					301:316	excellent biocompatibility	291:316	excellent biocompatibility	291:316	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	8	5	from	proportion	1240:1249	arg1	comparison					1263:1272	comparison	1263:1272	comparison with CaHPO4 rises	1263:1290	Additionally, as the proportion of CaCO3 in comparison with CaHPO4 rises, the mechanical properties improve.
33596707	1	6	theme	due	266:268	arg1	healing					236:242	wound healing	230:242	wound healing	230:242	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	7	7	dep	better	1176:1181	arg1	properties					1198:1207	the mechanical properties	1183:1207	the better the mechanical properties obtained	1172:1216	On the one hand, the higher the amount of minerals added to the composition, the better the mechanical properties obtained.
33596707	2	8	contain	have	441:444	arg2	properties					462:471	poor mechanical properties	446:471	poor mechanical properties	446:471	Nonetheless, their main drawback is that they have poor mechanical properties, consequently restricting their use in bone tissue engineering.
33596707	2	8	contain	have	441:444	arg1	they					436:439	they	436:439	they	436:439	Nonetheless, their main drawback is that they have poor mechanical properties, consequently restricting their use in bone tissue engineering.
33596707	3	9	attach	cross-linked	578:589	arg3	studies					549:555	previous studies	540:555	previous studies	540:555	In previous studies, both materials were cross-linked, with added calcium minerals, which led to an improvement in both mechanical and biological properties.
33596707	2	10	theme	tissue	517:522	arg1	engineering					524:534	bone tissue engineering	512:534	bone tissue engineering	512:534	Nonetheless, their main drawback is that they have poor mechanical properties, consequently restricting their use in bone tissue engineering.
33596707	1	11	theme	low	363:365	arg1	price					367:371	low price	363:371	low price	363:371	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	1	11	theme	low	363:365	arg1	advantages					279:288	their advantages	273:288	their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability	273:392	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	4	12	theme	scaffolds	794:802	arg1	characterization					757:772	a mechanical and biological characterization	729:772	a mechanical and biological characterization of mineral-hydrogel scaffolds in order to find the best compositions	729:841	Therefore, this study carries out a mechanical and biological characterization of mineral-hydrogel scaffolds in order to find the best compositions.
33596707	1	13	theme	wide	184:187	arg1	range					189:193	a wide range	182:193	a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability	182:392	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	1	13	theme	wide	184:187	arg1	regeneration					252:263	bone regeneration	247:263	bone regeneration	247:263	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	1	13	theme	wide	184:187	arg1	healing					236:242	wound healing	230:242	wound healing	230:242	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	2	14	theme	bone	512:515	arg1	engineering					524:534	bone tissue engineering	512:534	bone tissue engineering	512:534	Nonetheless, their main drawback is that they have poor mechanical properties, consequently restricting their use in bone tissue engineering.
33596707	3	15	theme	previous	540:547	arg1	studies					549:555	previous studies	540:555	previous studies	540:555	In previous studies, both materials were cross-linked, with added calcium minerals, which led to an improvement in both mechanical and biological properties.
33596707	3	16	from	improvement	637:647	arg1	properties					683:692	both mechanical and biological properties	652:692	both mechanical and biological properties	652:692	In previous studies, both materials were cross-linked, with added calcium minerals, which led to an improvement in both mechanical and biological properties.
33596707	2	17	theme	poor	446:449	arg1	properties					462:471	poor mechanical properties	446:471	poor mechanical properties	446:471	Nonetheless, their main drawback is that they have poor mechanical properties, consequently restricting their use in bone tissue engineering.
33596707	4	18	theme	mechanical	731:740	arg1	characterization					757:772	a mechanical and biological characterization	729:772	a mechanical and biological characterization of mineral-hydrogel scaffolds in order to find the best compositions	729:841	Therefore, this study carries out a mechanical and biological characterization of mineral-hydrogel scaffolds in order to find the best compositions.
33596707	0	19	theme	Biological	0:9	arg1	evaluation					26:35	Biological and mechanical evaluation	0:35	Biological and mechanical evaluation of mineralized-hydrogel	0:59	Biological and mechanical evaluation of mineralized-hydrogel scaffolds for tissue engineering applications.
33596707	1	20	used	used	151:154	arg2	gelatin					121:127	gelatin	121:127	gelatin	121:127	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	1	20	used	used	151:154	arg2	Chitosan					108:115	Chitosan	108:115	Chitosan	108:115	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	1	21	theme	different	198:206	arg1	healing					236:242	wound healing	230:242	wound healing	230:242	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	1	21	theme	different	198:206	arg1	applications					208:219	different applications	198:219	different applications	198:219	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	1	21	theme	different	198:206	arg1	regeneration					252:263	bone regeneration	247:263	bone regeneration	247:263	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	4	22	theme	biological	746:755	arg1	characterization					757:772	a mechanical and biological characterization	729:772	a mechanical and biological characterization of mineral-hydrogel scaffolds in order to find the best compositions	729:841	Therefore, this study carries out a mechanical and biological characterization of mineral-hydrogel scaffolds in order to find the best compositions.
33596707	4	23	theme	best	825:828	arg1	compositions					830:841	the best compositions	821:841	the best compositions	821:841	Therefore, this study carries out a mechanical and biological characterization of mineral-hydrogel scaffolds in order to find the best compositions.
33596707	1	24	theme	applications	208:219	arg1	range					189:193	a wide range	182:193	a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability	182:392	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	1	24	theme	applications	208:219	arg1	regeneration					252:263	bone regeneration	247:263	bone regeneration	247:263	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	1	24	theme	applications	208:219	arg1	healing					236:242	wound healing	230:242	wound healing	230:242	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	0	25	theme	mechanical	15:24	arg1	evaluation					26:35	Biological and mechanical evaluation	0:35	Biological and mechanical evaluation of mineralized-hydrogel	0:59	Biological and mechanical evaluation of mineralized-hydrogel scaffolds for tissue engineering applications.
33596707	7	26	theme	mechanical	1187:1196	arg1	properties					1198:1207	the mechanical properties	1183:1207	the better the mechanical properties obtained	1172:1216	On the one hand, the higher the amount of minerals added to the composition, the better the mechanical properties obtained.
33596707	0	27	theme	mineralized-hydrogel	40:59	arg1	evaluation					26:35	Biological and mechanical evaluation	0:35	Biological and mechanical evaluation of mineralized-hydrogel	0:59	Biological and mechanical evaluation of mineralized-hydrogel scaffolds for tissue engineering applications.
33596707	1	28	theme	excellent	291:299	arg1	advantages					279:288	their advantages	273:288	their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability	273:392	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	1	28	theme	excellent	291:299	arg1	biocompatibility					301:316	excellent biocompatibility	291:316	excellent biocompatibility	291:316	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	6	29	theme	minerals	1011:1018	arg1	addition					999:1006	This addition	994:1006	This addition of minerals	994:1018	This addition of minerals enhances not only the mechanical properties, but also the biological ones.
33596707	3	30	theme	added	597:601	arg1	minerals					611:618	added calcium minerals	597:618	added calcium minerals	597:618	In previous studies, both materials were cross-linked, with added calcium minerals, which led to an improvement in both mechanical and biological properties.
33596707	2	31	theme	main	414:417	arg1	drawback					419:426	their main drawback	408:426	their main drawback	408:426	Nonetheless, their main drawback is that they have poor mechanical properties, consequently restricting their use in bone tissue engineering.
33596707	5	32	theme	compounds	877:885	arg1	proportions					854:864	Different proportions	844:864	Different proportions of calcium compounds (CaCO3 and CaHPO4)	844:904	Different proportions of calcium compounds (CaCO3 and CaHPO4) are used to make up between 20% and 30% of the minerals used in a mineral-hydrogel mix.
33596707	3	33	theme	calcium	603:609	arg1	minerals					611:618	added calcium minerals	597:618	added calcium minerals	597:618	In previous studies, both materials were cross-linked, with added calcium minerals, which led to an improvement in both mechanical and biological properties.
33596707	5	34	theme	calcium	869:875	arg1	CaHPO4					898:903	CaHPO4	898:903	CaHPO4	898:903	Different proportions of calcium compounds (CaCO3 and CaHPO4) are used to make up between 20% and 30% of the minerals used in a mineral-hydrogel mix.
33596707	5	34	theme	calcium	869:875	arg1	CaCO3					888:892	CaCO3	888:892	CaCO3	888:892	Different proportions of calcium compounds (CaCO3 and CaHPO4) are used to make up between 20% and 30% of the minerals used in a mineral-hydrogel mix.
33596707	5	34	theme	calcium	869:875	arg1	compounds					877:885	calcium compounds	869:885	calcium compounds (CaCO3 and CaHPO4)	869:904	Different proportions of calcium compounds (CaCO3 and CaHPO4) are used to make up between 20% and 30% of the minerals used in a mineral-hydrogel mix.
33596707	2	35	from	use	505:507	arg1	engineering					524:534	bone tissue engineering	512:534	bone tissue engineering	512:534	Nonetheless, their main drawback is that they have poor mechanical properties, consequently restricting their use in bone tissue engineering.
33596707	5	36	dep	compounds	877:885	arg1	CaHPO4					898:903	CaHPO4	898:903	CaHPO4	898:903	Different proportions of calcium compounds (CaCO3 and CaHPO4) are used to make up between 20% and 30% of the minerals used in a mineral-hydrogel mix.
33596707	5	36	dep	compounds	877:885	arg1	CaCO3					888:892	CaCO3	888:892	CaCO3	888:892	Different proportions of calcium compounds (CaCO3 and CaHPO4) are used to make up between 20% and 30% of the minerals used in a mineral-hydrogel mix.
33596707	5	36	dep	compounds	877:885	arg1	compounds					877:885	calcium compounds	869:885	calcium compounds (CaCO3 and CaHPO4)	869:904	Different proportions of calcium compounds (CaCO3 and CaHPO4) are used to make up between 20% and 30% of the minerals used in a mineral-hydrogel mix.
33596707	8	37	theme	mechanical	1297:1306	arg1	properties					1308:1317	the mechanical properties	1293:1317	the mechanical properties	1293:1317	Additionally, as the proportion of CaCO3 in comparison with CaHPO4 rises, the mechanical properties improve.
33596707	9	38	theme	calcium	1424:1430	arg1	minerals					1432:1439	calcium minerals	1424:1439	calcium minerals	1424:1439	On the other hand, both cell proliferation and mineralization are improved with the addition of calcium minerals.
33596707	2	39	theme	mechanical	451:460	arg1	properties					462:471	poor mechanical properties	446:471	poor mechanical properties	446:471	Nonetheless, their main drawback is that they have poor mechanical properties, consequently restricting their use in bone tissue engineering.
33596707	8	40	with	comparison	1263:1272	arg1	CaHPO4					1279:1284	CaHPO4 rises	1279:1290	CaHPO4 rises	1279:1290	Additionally, as the proportion of CaCO3 in comparison with CaHPO4 rises, the mechanical properties improve.
33596707	9	41	theme	minerals	1432:1439	arg1	addition					1412:1419	the addition	1408:1419	the addition of calcium minerals	1408:1439	On the other hand, both cell proliferation and mineralization are improved with the addition of calcium minerals.
33596707	1	42	theme	cell	329:332	arg1	adhesion					334:341	cell adhesion	329:341	cell adhesion	329:341	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	3	43	theme	biological	672:681	arg1	properties					683:692	both mechanical and biological properties	652:692	both mechanical and biological properties	652:692	In previous studies, both materials were cross-linked, with added calcium minerals, which led to an improvement in both mechanical and biological properties.
33596707	1	44	theme	wound	230:234	arg1	healing					236:242	wound healing	230:242	wound healing	230:242	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	4	45	theme	mineral-hydrogel	777:792	arg1	scaffolds					794:802	mineral-hydrogel scaffolds	777:802	mineral-hydrogel scaffolds in order to find the best compositions	777:841	Therefore, this study carries out a mechanical and biological characterization of mineral-hydrogel scaffolds in order to find the best compositions.
33596707	6	46	theme	biological	1078:1087	arg1	ones					1089:1092	the biological ones	1074:1092	the biological ones	1074:1092	This addition of minerals enhances not only the mechanical properties, but also the biological ones.
33596707	0	47	theme	engineering	82:92	arg1	applications					94:105	tissue engineering applications	75:105	tissue engineering applications	75:105	Biological and mechanical evaluation of mineralized-hydrogel scaffolds for tissue engineering applications.
33596707	3	48	theme	mechanical	657:666	arg1	properties					683:692	both mechanical and biological properties	652:692	both mechanical and biological properties	652:692	In previous studies, both materials were cross-linked, with added calcium minerals, which led to an improvement in both mechanical and biological properties.
33596707	5	49	theme	Different	844:852	arg1	proportions					854:864	Different proportions	844:864	Different proportions of calcium compounds (CaCO3 and CaHPO4)	844:904	Different proportions of calcium compounds (CaCO3 and CaHPO4) are used to make up between 20% and 30% of the minerals used in a mineral-hydrogel mix.
33596707	1	50	theme	tissue	159:164	arg1	engineering					166:176	tissue engineering	159:176	tissue engineering	159:176	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33596707	6	51	theme	mechanical	1042:1051	arg1	properties					1053:1062	the mechanical properties	1038:1062	the mechanical properties	1038:1062	This addition of minerals enhances not only the mechanical properties, but also the biological ones.
33596707	9	52	theme	other	1335:1339	arg1	hand					1341:1344	the other hand	1331:1344	the other hand	1331:1344	On the other hand, both cell proliferation and mineralization are improved with the addition of calcium minerals.
33596707	0	53	theme	tissue	75:80	arg1	applications					94:105	tissue engineering applications	75:105	tissue engineering applications	75:105	Biological and mechanical evaluation of mineralized-hydrogel scaffolds for tissue engineering applications.
33596707	5	54	used	used	910:913	arg2	proportions					854:864	Different proportions	844:864	Different proportions of calcium compounds (CaCO3 and CaHPO4)	844:904	Different proportions of calcium compounds (CaCO3 and CaHPO4) are used to make up between 20% and 30% of the minerals used in a mineral-hydrogel mix.
33596707	5	55	theme	mineral-hydrogel	972:987	arg1	mix					989:991	a mineral-hydrogel mix	970:991	a mineral-hydrogel mix	970:991	Different proportions of calcium compounds (CaCO3 and CaHPO4) are used to make up between 20% and 30% of the minerals used in a mineral-hydrogel mix.
33596707	8	56	theme	CaCO3	1254:1258	arg1	proportion					1240:1249	the proportion	1236:1249	the proportion of CaCO3 in comparison with CaHPO4 rises	1236:1290	Additionally, as the proportion of CaCO3 in comparison with CaHPO4 rises, the mechanical properties improve.
33596707	1	57	theme	bone	247:250	arg1	regeneration					252:263	bone regeneration	247:263	bone regeneration	247:263	Chitosan and gelatin have been extensively used in tissue engineering for a wide range of different applications, such as wound healing or bone regeneration, due to their advantages: excellent biocompatibility (promoting cell adhesion and proliferation), low price and biodegradability.
33712120	4	0	theme	micropropagation	458:473	arg1	technology					475:484	an efficient micropropagation technology	445:484	an efficient micropropagation technology for P. puberula	445:500	Therefore, we established an efficient micropropagation technology for P. puberula through comparative analysis in mature leaves of regenerated and conventionally propagated plants.
33712120	6	1	from	cohesiveness	1053:1064	arg1	similar					995:1001	similar	995:1001	similar	995:1001	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	5	2	theme	functional	761:770	arg1	esterification					745:758	esterification	745:758	esterification	745:758	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	2	theme	functional	761:770	arg1	groups					772:777	functional groups	761:777	functional groups	761:777	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	2	theme	functional	761:770	arg1	acid					701:704	galacturonic acid	688:704	galacturonic acid	688:704	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	3	from	groups	772:777	arg1	similar					668:674	similar	668:674	similar	668:674	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	3	from	groups	772:777	arg1	composition					636:646	the pectin composition	625:646	the pectin composition of their leaves	625:662	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	6	4	from	springiness	1040:1050	arg1	similar					995:1001	similar	995:1001	similar	995:1001	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	2	5	theme	food	296:299	arg1	industry					301:308	the food industry	292:308	the food industry	292:308	In Premma puberula Pamp., the pectin content in leaves is 30 %-40 %, and it is widely used in the food industry and medicine.
33712120	8	6	theme	root	1295:1298	arg1	induction					1300:1308	root induction	1295:1308	root induction	1295:1308	The technical essentials include callus induction, embryoid formation, and root induction, followed by acclimatization and transplanting.
33712120	4	7	theme	regenerated	551:561	arg1	mature					534:539	mature	534:539	mature	534:539	Therefore, we established an efficient micropropagation technology for P. puberula through comparative analysis in mature leaves of regenerated and conventionally propagated plants.
33712120	5	8	theme	monosaccharide	707:720	arg1	composition					722:732	monosaccharide composition	707:732	monosaccharide composition	707:732	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	0	9	from	Composition	0:10	arg1	plants					90:95	micropropagated and conventional plants	57:95	micropropagated and conventional plants of Premma puberula Pamp	57:119	Composition and structural characterization of pectin in micropropagated and conventional plants of Premma puberula Pamp.
33712120	5	10	theme	their	651:655	arg1	similar					668:674	similar	668:674	similar	668:674	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	10	theme	their	651:655	arg1	composition					636:646	the pectin composition	625:646	the pectin composition of their leaves	625:662	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	6	11	from	similar	995:1001	arg1	cohesiveness					1053:1064	cohesiveness	1053:1064	cohesiveness	1053:1064	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	6	11	from	similar	995:1001	arg1	springiness					1040:1050	springiness	1040:1050	springiness	1040:1050	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	6	11	from	similar	995:1001	arg1	adhesiveness					1026:1037	adhesiveness	1026:1037	adhesiveness	1026:1037	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	6	11	from	similar	995:1001	arg1	viscoelasticity					1070:1084	viscoelasticity	1070:1084	viscoelasticity	1070:1084	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	6	11	from	similar	995:1001	arg1	stability					1015:1023	emulsion stability	1006:1023	emulsion stability	1006:1023	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	4	12	theme	propagated	582:591	arg1	plants					593:598	conventionally propagated plants	567:598	conventionally propagated plants	567:598	Therefore, we established an efficient micropropagation technology for P. puberula through comparative analysis in mature leaves of regenerated and conventionally propagated plants.
33712120	6	13	from	adhesiveness	1026:1037	arg1	similar					995:1001	similar	995:1001	similar	995:1001	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	2	14	theme	%	259:259	arg1	%					264:264	30 %-40 %	256:264	30 %-40 %	256:264	In Premma puberula Pamp., the pectin content in leaves is 30 %-40 %, and it is widely used in the food industry and medicine.
33712120	2	14	theme	%	259:259	arg1	content					235:241	the pectin content	224:241	the pectin content in leaves	224:251	In Premma puberula Pamp., the pectin content in leaves is 30 %-40 %, and it is widely used in the food industry and medicine.
33712120	0	15	theme	Pamp	116:119	arg1	plants					90:95	micropropagated and conventional plants	57:95	micropropagated and conventional plants of Premma puberula Pamp	57:119	Composition and structural characterization of pectin in micropropagated and conventional plants of Premma puberula Pamp.
33712120	4	16	theme	efficient	448:456	arg1	technology					475:484	an efficient micropropagation technology	445:484	an efficient micropropagation technology for P. puberula	445:500	Therefore, we established an efficient micropropagation technology for P. puberula through comparative analysis in mature leaves of regenerated and conventionally propagated plants.
33712120	4	17	from	analysis	522:529	arg1	mature					534:539	mature	534:539	mature	534:539	Therefore, we established an efficient micropropagation technology for P. puberula through comparative analysis in mature leaves of regenerated and conventionally propagated plants.
33712120	6	18	theme	micropropagated	864:878	arg1	plants					880:885	micropropagated plants	864:885	micropropagated plants	864:885	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	5	19	from	terms	679:683	arg1	similar					668:674	similar	668:674	similar	668:674	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	19	from	terms	679:683	arg1	composition					636:646	the pectin composition	625:646	the pectin composition of their leaves	625:662	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	1	20	theme	plant	176:180	arg1	culture					189:195	plant tissue culture	176:195	plant tissue culture	176:195	The metabolites produced by plants can be enhanced by plant tissue culture.
33712120	5	21	theme	resonance	797:805	arg1	spectrum					807:814	nuclear magnetic resonance spectrum	780:814	nuclear magnetic resonance spectrum	780:814	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	22	from	spectrum	807:814	arg1	similar					668:674	similar	668:674	similar	668:674	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	22	from	spectrum	807:814	arg1	composition					636:646	the pectin composition	625:646	the pectin composition of their leaves	625:662	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	6	23	from	stability	1015:1023	arg1	similar					995:1001	similar	995:1001	similar	995:1001	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	2	24	used	used	284:287	arg2	it					271:272	it	271:272	it	271:272	In Premma puberula Pamp., the pectin content in leaves is 30 %-40 %, and it is widely used in the food industry and medicine.
33712120	1	25	theme	tissue	182:187	arg1	culture					189:195	plant tissue culture	176:195	plant tissue culture	176:195	The metabolites produced by plants can be enhanced by plant tissue culture.
33712120	3	26	theme	inefficient	333:343	arg1	propagation					345:355	inefficient propagation	333:355	inefficient propagation	333:355	However, inefficient propagation has seriously restricted the utilization of pectin resources.
33712120	5	27	theme	pectin	629:634	arg1	similar					668:674	similar	668:674	similar	668:674	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	27	theme	pectin	629:634	arg1	composition					636:646	the pectin composition	625:646	the pectin composition of their leaves	625:662	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	7	28	theme	important	1142:1150	arg1	guarantee					1152:1160	an important guarantee	1139:1160	an important guarantee	1139:1160	Therefore, micropropagation technology will provide an important guarantee for the industrial production of pectin from P. puberula.
33712120	7	29	theme	pectin	1195:1200	arg1	production					1181:1190	the industrial production	1166:1190	the industrial production of pectin from P. puberula	1166:1217	Therefore, micropropagation technology will provide an important guarantee for the industrial production of pectin from P. puberula.
33712120	8	30	theme	embryoid	1271:1278	arg1	formation					1280:1288	embryoid formation	1271:1288	embryoid formation	1271:1288	The technical essentials include callus induction, embryoid formation, and root induction, followed by acclimatization and transplanting.
33712120	6	31	theme	emulsion	1006:1013	arg1	stability					1015:1023	emulsion stability	1006:1023	emulsion stability	1006:1023	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	5	32	theme	nuclear	780:786	arg1	resonance					797:805	nuclear magnetic resonance	780:805	nuclear magnetic resonance spectrum	780:814	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	2	33	from	content	235:241	arg1	leaves					246:251	leaves	246:251	leaves	246:251	In Premma puberula Pamp., the pectin content in leaves is 30 %-40 %, and it is widely used in the food industry and medicine.
33712120	0	34	theme	structural	16:25	arg1	characterization					27:42	structural characterization	16:42	structural characterization	16:42	Composition and structural characterization of pectin in micropropagated and conventional plants of Premma puberula Pamp.
33712120	5	35	theme	galacturonic	688:699	arg1	acid					701:704	galacturonic acid	688:704	galacturonic acid	688:704	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	0	36	theme	pectin	47:52	arg1	Composition					0:10	Composition	0:10	Composition	0:10	Composition and structural characterization of pectin in micropropagated and conventional plants of Premma puberula Pamp.
33712120	0	36	theme	pectin	47:52	arg1	characterization					27:42	structural characterization	16:42	structural characterization	16:42	Composition and structural characterization of pectin in micropropagated and conventional plants of Premma puberula Pamp.
33712120	5	37	theme	acid	701:704	arg1	characteristics					834:848	morphological characteristics	820:848	morphological characteristics	820:848	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	37	theme	acid	701:704	arg1	acid					701:704	galacturonic acid	688:704	galacturonic acid	688:704	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	37	theme	acid	701:704	arg1	esterification					745:758	esterification	745:758	esterification	745:758	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	37	theme	acid	701:704	arg1	spectrum					807:814	nuclear magnetic resonance spectrum	780:814	nuclear magnetic resonance spectrum	780:814	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	37	theme	acid	701:704	arg1	terms					679:683	terms	679:683	terms of galacturonic acid	679:704	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	37	theme	acid	701:704	arg1	composition					722:732	monosaccharide composition	707:732	monosaccharide composition	707:732	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	37	theme	acid	701:704	arg1	groups					772:777	functional groups	761:777	functional groups	761:777	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	37	theme	acid	701:704	arg1	degree					735:740	degree	735:740	degree of esterification	735:758	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	38	from	degree	735:740	arg1	similar					668:674	similar	668:674	similar	668:674	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	38	from	degree	735:740	arg1	composition					636:646	the pectin composition	625:646	the pectin composition of their leaves	625:662	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	2	39	theme	pectin	228:233	arg1	%					264:264	30 %-40 %	256:264	30 %-40 %	256:264	In Premma puberula Pamp., the pectin content in leaves is 30 %-40 %, and it is widely used in the food industry and medicine.
33712120	2	39	theme	pectin	228:233	arg1	content					235:241	the pectin content	224:241	the pectin content in leaves	224:251	In Premma puberula Pamp., the pectin content in leaves is 30 %-40 %, and it is widely used in the food industry and medicine.
33712120	3	40	theme	resources	408:416	arg1	utilization					386:396	the utilization	382:396	the utilization of pectin resources	382:416	However, inefficient propagation has seriously restricted the utilization of pectin resources.
33712120	6	41	theme	propagated	968:977	arg1	plants					979:984	conventionally propagated plants	953:984	conventionally propagated plants	953:984	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	0	42	theme	micropropagated	57:71	arg1	plants					90:95	micropropagated and conventional plants	57:95	micropropagated and conventional plants of Premma puberula Pamp	57:119	Composition and structural characterization of pectin in micropropagated and conventional plants of Premma puberula Pamp.
33712120	8	43	theme	technical	1224:1232	arg1	essentials					1234:1243	The technical essentials	1220:1243	The technical essentials	1220:1243	The technical essentials include callus induction, embryoid formation, and root induction, followed by acclimatization and transplanting.
33712120	5	44	from	composition	722:732	arg1	similar					668:674	similar	668:674	similar	668:674	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	44	from	composition	722:732	arg1	composition					636:646	the pectin composition	625:646	the pectin composition of their leaves	625:662	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	4	45	dep	mature	534:539	arg1	leaves					541:546	leaves	541:546	leaves	541:546	Therefore, we established an efficient micropropagation technology for P. puberula through comparative analysis in mature leaves of regenerated and conventionally propagated plants.
33712120	5	46	theme	magnetic	788:795	arg1	resonance					797:805	nuclear magnetic resonance	780:805	nuclear magnetic resonance spectrum	780:814	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	7	47	theme	micropropagation	1098:1113	arg1	technology					1115:1124	micropropagation technology	1098:1124	micropropagation technology	1098:1124	Therefore, micropropagation technology will provide an important guarantee for the industrial production of pectin from P. puberula.
33712120	7	48	from	puberula	1210:1217	arg1	production					1181:1190	the industrial production	1166:1190	the industrial production of pectin from P. puberula	1166:1217	Therefore, micropropagation technology will provide an important guarantee for the industrial production of pectin from P. puberula.
33712120	5	49	from	characteristics	834:848	arg1	similar					668:674	similar	668:674	similar	668:674	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	49	from	characteristics	834:848	arg1	composition					636:646	the pectin composition	625:646	the pectin composition of their leaves	625:662	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	6	50	from	viscoelasticity	1070:1084	arg1	similar					995:1001	similar	995:1001	similar	995:1001	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	4	51	theme	comparative	510:520	arg1	analysis					522:529	comparative analysis	510:529	comparative analysis in mature leaves of regenerated and conventionally propagated plants	510:598	Therefore, we established an efficient micropropagation technology for P. puberula through comparative analysis in mature leaves of regenerated and conventionally propagated plants.
33712120	6	52	contain	had	887:889	arg1	plants					880:885	micropropagated plants	864:885	micropropagated plants	864:885	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	6	52	contain	had	887:889	arg2	characteristics					932:946	chewiness characteristics	922:946	chewiness characteristics	922:946	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	6	52	contain	had	887:889	arg2	gumminess					908:916	gumminess	908:916	gumminess	908:916	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	6	52	contain	had	887:889	arg2	hardness					898:905	hardness	898:905	hardness	898:905	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	8	53	theme	callus	1253:1258	arg1	induction					1260:1268	callus induction	1253:1268	callus induction	1253:1268	The technical essentials include callus induction, embryoid formation, and root induction, followed by acclimatization and transplanting.
33712120	7	54	theme	industrial	1170:1179	arg1	production					1181:1190	the industrial production	1166:1190	the industrial production of pectin from P. puberula	1166:1217	Therefore, micropropagation technology will provide an important guarantee for the industrial production of pectin from P. puberula.
33712120	2	55	from	%	264:264	arg1	Pamp.					217:221	Pamp.	217:221	Pamp.	217:221	In Premma puberula Pamp., the pectin content in leaves is 30 %-40 %, and it is widely used in the food industry and medicine.
33712120	4	56	theme	plants	593:598	arg1	mature					534:539	mature	534:539	mature	534:539	Therefore, we established an efficient micropropagation technology for P. puberula through comparative analysis in mature leaves of regenerated and conventionally propagated plants.
33712120	0	57	theme	conventional	77:88	arg1	plants					90:95	micropropagated and conventional plants	57:95	micropropagated and conventional plants of Premma puberula Pamp	57:119	Composition and structural characterization of pectin in micropropagated and conventional plants of Premma puberula Pamp.
33712120	3	58	theme	pectin	401:406	arg1	resources					408:416	pectin resources	401:416	pectin resources	401:416	However, inefficient propagation has seriously restricted the utilization of pectin resources.
33712120	6	59	theme	chewiness	922:930	arg1	characteristics					932:946	chewiness characteristics	922:946	chewiness characteristics	922:946	Furthermore, micropropagated plants had better hardness, gumminess and chewiness characteristics than conventionally propagated plants and were similar in emulsion stability, adhesiveness, springiness, cohesiveness and viscoelasticity.
33712120	5	60	theme	esterification	745:758	arg1	characteristics					834:848	morphological characteristics	820:848	morphological characteristics	820:848	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	60	theme	esterification	745:758	arg1	acid					701:704	galacturonic acid	688:704	galacturonic acid	688:704	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	60	theme	esterification	745:758	arg1	esterification					745:758	esterification	745:758	esterification	745:758	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	60	theme	esterification	745:758	arg1	spectrum					807:814	nuclear magnetic resonance spectrum	780:814	nuclear magnetic resonance spectrum	780:814	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	60	theme	esterification	745:758	arg1	terms					679:683	terms	679:683	terms of galacturonic acid	679:704	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	60	theme	esterification	745:758	arg1	composition					722:732	monosaccharide composition	707:732	monosaccharide composition	707:732	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	60	theme	esterification	745:758	arg1	groups					772:777	functional groups	761:777	functional groups	761:777	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	60	theme	esterification	745:758	arg1	degree					735:740	degree	735:740	degree of esterification	735:758	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	0	61	from	characterization	27:42	arg1	plants					90:95	micropropagated and conventional plants	57:95	micropropagated and conventional plants of Premma puberula Pamp	57:119	Composition and structural characterization of pectin in micropropagated and conventional plants of Premma puberula Pamp.
33712120	5	62	theme	morphological	820:832	arg1	characteristics					834:848	morphological characteristics	820:848	morphological characteristics	820:848	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	63	dep	their	651:655	arg1	leaves					657:662	leaves	657:662	leaves	657:662	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	64	from	similar	668:674	arg1	characteristics					834:848	morphological characteristics	820:848	morphological characteristics	820:848	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	64	from	similar	668:674	arg1	acid					701:704	galacturonic acid	688:704	galacturonic acid	688:704	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	64	from	similar	668:674	arg1	esterification					745:758	esterification	745:758	esterification	745:758	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	64	from	similar	668:674	arg1	spectrum					807:814	nuclear magnetic resonance spectrum	780:814	nuclear magnetic resonance spectrum	780:814	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	64	from	similar	668:674	arg1	terms					679:683	terms	679:683	terms of galacturonic acid	679:704	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	64	from	similar	668:674	arg1	composition					722:732	monosaccharide composition	707:732	monosaccharide composition	707:732	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	64	from	similar	668:674	arg1	groups					772:777	functional groups	761:777	functional groups	761:777	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
33712120	5	64	from	similar	668:674	arg1	degree					735:740	degree	735:740	degree of esterification	735:758	The results showed that the pectin composition of their leaves was similar in terms of galacturonic acid, monosaccharide composition, degree of esterification, functional groups, nuclear magnetic resonance spectrum and morphological characteristics.
32228889	7	0	theme	red	1060:1062	arg1	staining					1064:1071	Sirius red staining	1053:1071	Sirius red staining	1053:1071	As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion.
32228889	10	1	theme	multifunctional	1554:1568	arg1	basis					1669:1673	a basis	1667:1673	a basis for approaches	1667:1688	In summary, our multifunctional composite scaffolds showed optimised structure, enhanced regenerative capabilities, and serve as a basis for approaches to improve GTR designs for periodontal regeneration.
32228889	10	1	theme	multifunctional	1554:1568	arg1	scaffolds					1580:1588	our multifunctional composite scaffolds	1550:1588	our multifunctional composite scaffolds	1550:1588	In summary, our multifunctional composite scaffolds showed optimised structure, enhanced regenerative capabilities, and serve as a basis for approaches to improve GTR designs for periodontal regeneration.
32228889	10	2	theme	optimised	1597:1605	arg1	structure					1607:1615	optimised structure	1597:1615	optimised structure	1597:1615	In summary, our multifunctional composite scaffolds showed optimised structure, enhanced regenerative capabilities, and serve as a basis for approaches to improve GTR designs for periodontal regeneration.
32228889	6	3	theme	tissue	951:956	arg1	process					971:977	tissue regeneration process	951:977	tissue regeneration process	951:977	Appropriate degradation rates were approved by degradability analysis in vitro and in vivo, which resembled tissue regeneration process more closely.
32228889	7	4	theme	secretion	1218:1226	arg1	levels					1199:1204	high levels	1194:1204	high levels of collagen secretion	1194:1226	As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion.
32228889	7	5	theme	cell	1027:1030	arg1	assay					1043:1047	cell attachment assay	1027:1047	cell attachment assay	1027:1047	As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion.
32228889	9	6	theme	cell	1523:1526	arg1	invasion					1528:1535	external cell invasion	1514:1535	external cell invasion	1514:1535	The results from subcutaneous implantation revealed the scaffolds had strong cell barrier effects and protection from external cell invasion.
32228889	9	7	theme	subcutaneous	1413:1424	arg1	implantation					1426:1437	subcutaneous implantation	1413:1437	subcutaneous implantation	1413:1437	The results from subcutaneous implantation revealed the scaffolds had strong cell barrier effects and protection from external cell invasion.
32228889	6	8	theme	degradability	890:902	arg1	analysis					904:911	degradability analysis	890:911	degradability analysis	890:911	Appropriate degradation rates were approved by degradability analysis in vitro and in vivo, which resembled tissue regeneration process more closely.
32228889	7	9	contain	had	1101:1103	arg1	scaffolds					1091:1099	the scaffolds	1087:1099	the scaffolds	1087:1099	As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion.
32228889	7	9	contain	had	1101:1103	arg2	biocompatibility					1110:1125	good biocompatibility	1105:1125	good biocompatibility	1105:1125	As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion.
32228889	8	10	theme	effective	1374:1382	arg1	hemostasis					1384:1393	effective hemostasis	1374:1393	effective hemostasis	1374:1393	Experiments of blood clotting measurement in vitro showed that composite scaffolds were capable of accelerating blood clotting and could realize effective hemostasis.
32228889	5	11	theme	good	809:812	arg1	swelling					814:821	good swelling	809:821	good swelling	809:821	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	4	12	theme	sandwich-like	540:552	arg1	construction					554:565	A chitosan/polycaprolactone/gelatin sandwich-like construction	504:565	A chitosan/polycaprolactone/gelatin sandwich-like construction	504:565	A chitosan/polycaprolactone/gelatin sandwich-like construction was fabricated by electrospinning and lyophilization.
32228889	7	13	theme	attachment	1032:1041	arg1	assay					1043:1047	cell attachment assay	1027:1047	cell attachment assay	1027:1047	As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion.
32228889	3	14	theme	unique	470:475	arg1	scaffolds					493:501	unique multifunctional scaffolds	470:501	unique multifunctional scaffolds	470:501	To overcome these shortcomings, we generated unique multifunctional scaffolds.
32228889	10	15	theme	periodontal	1717:1727	arg1	regeneration					1729:1740	periodontal regeneration	1717:1740	periodontal regeneration	1717:1740	In summary, our multifunctional composite scaffolds showed optimised structure, enhanced regenerative capabilities, and serve as a basis for approaches to improve GTR designs for periodontal regeneration.
32228889	9	16	theme	external	1514:1521	arg1	invasion					1528:1535	external cell invasion	1514:1535	external cell invasion	1514:1535	The results from subcutaneous implantation revealed the scaffolds had strong cell barrier effects and protection from external cell invasion.
32228889	10	17	theme	composite	1570:1578	arg1	basis					1669:1673	a basis	1667:1673	a basis for approaches	1667:1688	In summary, our multifunctional composite scaffolds showed optimised structure, enhanced regenerative capabilities, and serve as a basis for approaches to improve GTR designs for periodontal regeneration.
32228889	10	17	theme	composite	1570:1578	arg1	scaffolds					1580:1588	our multifunctional composite scaffolds	1550:1588	our multifunctional composite scaffolds	1550:1588	In summary, our multifunctional composite scaffolds showed optimised structure, enhanced regenerative capabilities, and serve as a basis for approaches to improve GTR designs for periodontal regeneration.
32228889	1	18	theme	Periodontal	113:123	arg1	complication					145:156	a common complication	136:156	a common complication	136:156	Periodontal disease is a common complication and conventional periodontal surgery can lead to severe bleeding.
32228889	1	18	theme	Periodontal	113:123	arg1	disease					125:131	Periodontal disease	113:131	Periodontal disease	113:131	Periodontal disease is a common complication and conventional periodontal surgery can lead to severe bleeding.
32228889	9	19	theme	strong	1466:1471	arg1	effects					1486:1492	strong cell barrier effects	1466:1492	strong cell barrier effects	1466:1492	The results from subcutaneous implantation revealed the scaffolds had strong cell barrier effects and protection from external cell invasion.
32228889	3	20	theme	multifunctional	477:491	arg1	scaffolds					493:501	unique multifunctional scaffolds	470:501	unique multifunctional scaffolds	470:501	To overcome these shortcomings, we generated unique multifunctional scaffolds.
32228889	6	21	theme	regeneration	958:969	arg1	process					971:977	tissue regeneration process	951:977	tissue regeneration process	951:977	Appropriate degradation rates were approved by degradability analysis in vitro and in vivo, which resembled tissue regeneration process more closely.
32228889	5	22	theme	pore	732:735	arg1	size					737:740	pore size	732:740	pore size (about 10 μm)	732:754	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	7	23	theme	viability	1010:1018	arg1	assay					1020:1024	cell viability assay	1005:1024	cell viability assay	1005:1024	As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion.
32228889	10	24	theme	GTR	1701:1703	arg1	designs					1705:1711	GTR designs	1701:1711	GTR designs	1701:1711	In summary, our multifunctional composite scaffolds showed optimised structure, enhanced regenerative capabilities, and serve as a basis for approaches to improve GTR designs for periodontal regeneration.
32228889	8	25	theme	blood	1244:1248	arg1	Experiments					1229:1239	Experiments	1229:1239	Experiments of blood clotting measurement in vitro	1229:1278	Experiments of blood clotting measurement in vitro showed that composite scaffolds were capable of accelerating blood clotting and could realize effective hemostasis.
32228889	7	26	theme	collagen	1209:1216	arg1	secretion					1218:1226	collagen secretion	1209:1226	collagen secretion	1209:1226	As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion.
32228889	7	27	theme	cell	1153:1156	arg1	ability					1158:1164	cell ability	1153:1164	cell ability for attachment	1153:1179	As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion.
32228889	7	28	theme	cell	1005:1008	arg1	assay					1020:1024	cell viability assay	1005:1024	cell viability assay	1005:1024	As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion.
32228889	2	29	theme	improper	336:343	arg1	biodegradation					345:358	improper biodegradation	336:358	improper biodegradation	336:358	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	2	30	theme	hemostatic	404:413	arg1	property					415:422	no effective hemostatic property	391:422	no effective hemostatic property	391:422	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	0	31	theme	chitosan/polycaprolactone/gelatin	28:60	arg1	Potentials					0:9	Potentials	0:9	Potentials of sandwich-like chitosan/polycaprolactone/gelatin	0:60	Potentials of sandwich-like chitosan/polycaprolactone/gelatin scaffolds for guided tissue regeneration membrane.
32228889	2	32	contain	have	310:313	arg2	biodegradation					345:358	improper biodegradation	336:358	improper biodegradation	336:358	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	2	32	contain	have	310:313	arg2	limitations					315:325	limitations	315:325	limitations	315:325	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	2	32	contain	have	310:313	arg2	property					377:384	poor mechanical property	361:384	poor mechanical property	361:384	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	2	32	contain	have	310:313	arg2	property					415:422	no effective hemostatic property	391:422	no effective hemostatic property	391:422	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	2	32	contain	have	310:313	arg1	they					299:302	they	299:302	they	299:302	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	5	33	theme	appropriate	703:713	arg1	porosity					715:722	appropriate porosity	703:722	appropriate porosity (<50%)	703:729	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	33	theme	appropriate	703:713	arg1	%					728:728	<50%	725:728	<50%	725:728	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	8	34	theme	blood	1341:1345	arg1	clotting					1347:1354	blood clotting	1341:1354	blood clotting	1341:1354	Experiments of blood clotting measurement in vitro showed that composite scaffolds were capable of accelerating blood clotting and could realize effective hemostasis.
32228889	0	35	theme	sandwich-like	14:26	arg1	chitosan/polycaprolactone/gelatin					28:60	sandwich-like chitosan/polycaprolactone/gelatin	14:60	sandwich-like chitosan/polycaprolactone/gelatin	14:60	Potentials of sandwich-like chitosan/polycaprolactone/gelatin scaffolds for guided tissue regeneration membrane.
32228889	9	36	from	invasion	1528:1535	arg1	protection					1498:1507	protection	1498:1507	protection from external cell invasion	1498:1535	The results from subcutaneous implantation revealed the scaffolds had strong cell barrier effects and protection from external cell invasion.
32228889	9	36	from	invasion	1528:1535	arg1	effects					1486:1492	strong cell barrier effects	1466:1492	strong cell barrier effects	1466:1492	The results from subcutaneous implantation revealed the scaffolds had strong cell barrier effects and protection from external cell invasion.
32228889	2	37	theme	Guided	224:229	arg1	regeneration					238:249	Guided tissue regeneration	224:249	Guided tissue regeneration (GTR) membranes	224:265	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	2	37	theme	Guided	224:229	arg1	GTR					252:254	GTR	252:254	GTR	252:254	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	1	38	theme	common	138:143	arg1	complication					145:156	a common complication	136:156	a common complication	136:156	Periodontal disease is a common complication and conventional periodontal surgery can lead to severe bleeding.
32228889	1	38	theme	common	138:143	arg1	disease					125:131	Periodontal disease	113:131	Periodontal disease	113:131	Periodontal disease is a common complication and conventional periodontal surgery can lead to severe bleeding.
32228889	5	39	with	size	737:740	arg1	PCL					803:805	more PCL	798:805	more PCL	798:805	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	40	theme	more	798:801	arg1	PCL					803:805	more PCL	798:805	more PCL	798:805	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	2	41	theme	periodontal	273:283	arg1	regrowth					285:292	periodontal regrowth	273:292	periodontal regrowth	273:292	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	7	42	theme	high	1194:1197	arg1	levels					1199:1204	high levels	1194:1204	high levels of collagen secretion	1194:1226	As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion.
32228889	5	43	with	stability	771:779	arg1	PCL					803:805	more PCL	798:805	more PCL	798:805	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	44	dep	size	737:740	arg1	10 μm					749:753	10 μm	749:753	10 μm	749:753	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	4	45	theme	chitosan/polycaprolactone/gelatin	506:538	arg1	construction					554:565	A chitosan/polycaprolactone/gelatin sandwich-like construction	504:565	A chitosan/polycaprolactone/gelatin sandwich-like construction	504:565	A chitosan/polycaprolactone/gelatin sandwich-like construction was fabricated by electrospinning and lyophilization.
32228889	5	46	with	swelling	814:821	arg1	PCL					803:805	more PCL	798:805	more PCL	798:805	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	6	47	theme	Appropriate	843:853	arg1	rates					867:871	Appropriate degradation rates	843:871	Appropriate degradation rates	843:871	Appropriate degradation rates were approved by degradability analysis in vitro and in vivo, which resembled tissue regeneration process more closely.
32228889	9	48	theme	cell	1473:1476	arg1	effects					1486:1492	strong cell barrier effects	1466:1492	strong cell barrier effects	1466:1492	The results from subcutaneous implantation revealed the scaffolds had strong cell barrier effects and protection from external cell invasion.
32228889	0	49	theme	tissue	83:88	arg1	regeneration					90:101	guided tissue regeneration	76:101	guided tissue regeneration membrane	76:110	Potentials of sandwich-like chitosan/polycaprolactone/gelatin scaffolds for guided tissue regeneration membrane.
32228889	7	50	theme	good	1105:1108	arg1	biocompatibility					1110:1125	good biocompatibility	1105:1125	good biocompatibility	1105:1125	As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion.
32228889	5	51	theme	favorable	654:662	arg1	hydrophilicity					827:840	hydrophilicity	827:840	hydrophilicity	827:840	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	51	theme	favorable	654:662	arg1	size					737:740	pore size	732:740	pore size (about 10 μm)	732:754	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	51	theme	favorable	654:662	arg1	porosity					715:722	appropriate porosity	703:722	appropriate porosity (<50%)	703:729	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	51	theme	favorable	654:662	arg1	swelling					814:821	good swelling	809:821	good swelling	809:821	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	51	theme	favorable	654:662	arg1	properties					680:689	favorable physicochemical properties	654:689	favorable physicochemical properties	654:689	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	0	52	theme	guided	76:81	arg1	regeneration					90:101	guided tissue regeneration	76:101	guided tissue regeneration membrane	76:110	Potentials of sandwich-like chitosan/polycaprolactone/gelatin scaffolds for guided tissue regeneration membrane.
32228889	5	53	with	porosity	715:722	arg1	PCL					803:805	more PCL	798:805	more PCL	798:805	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	54	theme	mechanical	760:769	arg1	stability					771:779	mechanical stability	760:779	mechanical stability	760:779	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	55	theme	physicochemical	664:678	arg1	hydrophilicity					827:840	hydrophilicity	827:840	hydrophilicity	827:840	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	55	theme	physicochemical	664:678	arg1	size					737:740	pore size	732:740	pore size (about 10 μm)	732:754	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	55	theme	physicochemical	664:678	arg1	porosity					715:722	appropriate porosity	703:722	appropriate porosity (<50%)	703:729	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	55	theme	physicochemical	664:678	arg1	swelling					814:821	good swelling	809:821	good swelling	809:821	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	55	theme	physicochemical	664:678	arg1	properties					680:689	favorable physicochemical properties	654:689	favorable physicochemical properties	654:689	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	2	56	theme	mechanical	366:375	arg1	property					377:384	poor mechanical property	361:384	poor mechanical property	361:384	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	6	57	theme	degradation	855:865	arg1	rates					867:871	Appropriate degradation rates	843:871	Appropriate degradation rates	843:871	Appropriate degradation rates were approved by degradability analysis in vitro and in vivo, which resembled tissue regeneration process more closely.
32228889	10	58	theme	regenerative	1627:1638	arg1	capabilities					1640:1651	regenerative capabilities	1627:1651	regenerative capabilities	1627:1651	In summary, our multifunctional composite scaffolds showed optimised structure, enhanced regenerative capabilities, and serve as a basis for approaches to improve GTR designs for periodontal regeneration.
32228889	1	59	theme	conventional	162:173	arg1	surgery					187:193	conventional periodontal surgery	162:193	conventional periodontal surgery	162:193	Periodontal disease is a common complication and conventional periodontal surgery can lead to severe bleeding.
32228889	7	60	theme	Sirius	1053:1058	arg1	staining					1064:1071	Sirius red staining	1053:1071	Sirius red staining	1053:1071	As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion.
32228889	9	61	theme	barrier	1478:1484	arg1	effects					1486:1492	strong cell barrier effects	1466:1492	strong cell barrier effects	1466:1492	The results from subcutaneous implantation revealed the scaffolds had strong cell barrier effects and protection from external cell invasion.
32228889	2	62	theme	regeneration	238:249	arg1	membranes					257:265	Guided tissue regeneration (GTR) membranes	224:265	Guided tissue regeneration (GTR) membranes	224:265	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	1	63	theme	periodontal	175:185	arg1	surgery					187:193	conventional periodontal surgery	162:193	conventional periodontal surgery	162:193	Periodontal disease is a common complication and conventional periodontal surgery can lead to severe bleeding.
32228889	8	64	theme	composite	1292:1300	arg1	scaffolds					1302:1310	composite scaffolds	1292:1310	composite scaffolds	1292:1310	Experiments of blood clotting measurement in vitro showed that composite scaffolds were capable of accelerating blood clotting and could realize effective hemostasis.
32228889	2	65	theme	poor	361:364	arg1	property					377:384	poor mechanical property	361:384	poor mechanical property	361:384	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	2	66	theme	tissue	231:236	arg1	regeneration					238:249	Guided tissue regeneration	224:249	Guided tissue regeneration (GTR) membranes	224:265	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	2	66	theme	tissue	231:236	arg1	GTR					252:254	GTR	252:254	GTR	252:254	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	9	67	from	implantation	1426:1437	arg1	results					1400:1406	The results	1396:1406	The results from subcutaneous implantation	1396:1437	The results from subcutaneous implantation revealed the scaffolds had strong cell barrier effects and protection from external cell invasion.
32228889	2	68	theme	effective	394:402	arg1	property					415:422	no effective hemostatic property	391:422	no effective hemostatic property	391:422	Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property.
32228889	0	69	theme	regeneration	90:101	arg1	membrane					103:110	guided tissue regeneration membrane	76:110	guided tissue regeneration membrane	76:110	Potentials of sandwich-like chitosan/polycaprolactone/gelatin scaffolds for guided tissue regeneration membrane.
32228889	5	70	with	hydrophilicity	827:840	arg1	PCL					803:805	more PCL	798:805	more PCL	798:805	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
32228889	5	71	theme	composite	627:635	arg1	scaffolds					637:645	These composite scaffolds	621:645	These composite scaffolds	621:645	These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity.
33158075	0	0	theme	Flame	91:95	arg1	Retardants					97:106	Sustainable Flame Retardants	79:106	Sustainable Flame Retardants	79:106	Suitability and Modification of Different Renewable Materials as Feedstock for Sustainable Flame Retardants.
33158075	9	1	theme	fiber	889:893	arg1	industry					895:902	the wood fiber industry	880:902	the wood fiber industry	880:902	The results indicate that these modified biopolymers can provide the same flame-retardant performances as commercial compounds currently used in the wood fiber industry.
33158075	0	2	theme	Sustainable	79:89	arg1	Retardants					97:106	Sustainable Flame Retardants	79:106	Sustainable Flame Retardants	79:106	Suitability and Modification of Different Renewable Materials as Feedstock for Sustainable Flame Retardants.
33158075	4	3	theme	phosphate	518:526	arg1	salts					528:532	phosphate salts	518:532	phosphate salts in molten urea	518:547	Wheat starch, wheat protein, xylan and tannin were modified with phosphate salts in molten urea.
33158075	3	4	from	research	350:357	arg1	retardants					379:388	innovative flame retardants	362:388	innovative flame retardants based on sustainable materials	362:419	For this reason, research on innovative flame retardants based on sustainable materials is the main focus of this work.
33158075	5	5	theme	phosphates	602:611	arg1	incorporation					585:597	the incorporation	581:597	the incorporation of phosphates (up to 48 wt	581:624	The functionalization leads to the incorporation of phosphates (up to 48 wt.
33158075	10	6	theme	used	1026:1029	arg1	biopolymer					1031:1040	the used biopolymer	1022:1040	the used biopolymer	1022:1040	Besides, the flame retardancy smoldering effects may also be reduced compared to unmodified wood fibers depending on the used biopolymer.
33158075	9	7	theme	modified	767:774	arg1	biopolymers					776:786	these modified biopolymers	761:786	these modified biopolymers	761:786	The results indicate that these modified biopolymers can provide the same flame-retardant performances as commercial compounds currently used in the wood fiber industry.
33158075	11	8	theme	conventional	1153:1164	arg1	retardants					1172:1181	conventional flame retardants	1153:1181	conventional flame retardants	1153:1181	These results show that different biopolymers modified in phosphate/urea systems are a serious alternative to conventional flame retardants.
33158075	11	9	theme	flame	1166:1170	arg1	retardants					1172:1181	conventional flame retardants	1153:1181	conventional flame retardants	1153:1181	These results show that different biopolymers modified in phosphate/urea systems are a serious alternative to conventional flame retardants.
33158075	3	10	theme	innovative	362:371	arg1	retardants					379:388	innovative flame retardants	362:388	innovative flame retardants based on sustainable materials	362:419	For this reason, research on innovative flame retardants based on sustainable materials is the main focus of this work.
33158075	9	11	theme	same	804:807	arg1	performances					825:836	the same flame-retardant performances	800:836	the same flame-retardant performances	800:836	The results indicate that these modified biopolymers can provide the same flame-retardant performances as commercial compounds currently used in the wood fiber industry.
33158075	9	11	theme	same	804:807	arg1	compounds					852:860	commercial compounds	841:860	commercial compounds currently used in the wood fiber industry	841:902	The results indicate that these modified biopolymers can provide the same flame-retardant performances as commercial compounds currently used in the wood fiber industry.
33158075	6	12	dep	22	649:650	arg1	to					646:647	to	646:647	to	646:647	%) and nitrogen (up to 22 wt.
33158075	3	13	theme	flame	373:377	arg1	retardants					379:388	innovative flame retardants	362:388	innovative flame retardants based on sustainable materials	362:419	For this reason, research on innovative flame retardants based on sustainable materials is the main focus of this work.
33158075	4	14	mod	modified	504:511	arg3	salts					528:532	phosphate salts	518:532	phosphate salts in molten urea	518:547	Wheat starch, wheat protein, xylan and tannin were modified with phosphate salts in molten urea.
33158075	4	14	mod	modified	504:511	arg1	tannin					492:497	tannin	492:497	tannin	492:497	Wheat starch, wheat protein, xylan and tannin were modified with phosphate salts in molten urea.
33158075	4	14	mod	modified	504:511	arg1	xylan					482:486	xylan	482:486	xylan	482:486	Wheat starch, wheat protein, xylan and tannin were modified with phosphate salts in molten urea.
33158075	4	14	mod	modified	504:511	arg1	starch					459:464	Wheat starch	453:464	Wheat starch	453:464	Wheat starch, wheat protein, xylan and tannin were modified with phosphate salts in molten urea.
33158075	4	14	mod	modified	504:511	arg1	protein					473:479	wheat protein	467:479	wheat protein	467:479	Wheat starch, wheat protein, xylan and tannin were modified with phosphate salts in molten urea.
33158075	0	15	theme	Materials	52:60	arg1	Modification					16:27	Modification	16:27	Modification	16:27	Suitability and Modification of Different Renewable Materials as Feedstock for Sustainable Flame Retardants.
33158075	0	15	theme	Materials	52:60	arg1	Suitability					0:10	Suitability	0:10	Suitability	0:10	Suitability and Modification of Different Renewable Materials as Feedstock for Sustainable Flame Retardants.
33158075	3	16	theme	work	447:450	arg1	research					350:357	research	350:357	research on innovative flame retardants based on sustainable materials	350:419	For this reason, research on innovative flame retardants based on sustainable materials is the main focus of this work.
33158075	3	16	theme	work	447:450	arg1	focus					433:437	the main focus	424:437	the main focus of this work	424:450	For this reason, research on innovative flame retardants based on sustainable materials is the main focus of this work.
33158075	9	17	theme	flame-retardant	809:823	arg1	performances					825:836	the same flame-retardant performances	800:836	the same flame-retardant performances	800:836	The results indicate that these modified biopolymers can provide the same flame-retardant performances as commercial compounds currently used in the wood fiber industry.
33158075	9	17	theme	flame-retardant	809:823	arg1	compounds					852:860	commercial compounds	841:860	commercial compounds currently used in the wood fiber industry	841:902	The results indicate that these modified biopolymers can provide the same flame-retardant performances as commercial compounds currently used in the wood fiber industry.
33158075	10	18	theme	flame	918:922	arg1	effects					946:952	the flame retardancy smoldering effects	914:952	the flame retardancy smoldering effects	914:952	Besides, the flame retardancy smoldering effects may also be reduced compared to unmodified wood fibers depending on the used biopolymer.
33158075	3	19	theme	sustainable	399:409	arg1	materials					411:419	sustainable materials	399:419	sustainable materials	399:419	For this reason, research on innovative flame retardants based on sustainable materials is the main focus of this work.
33158075	10	20	theme	wood	997:1000	arg1	fibers					1002:1007	unmodified wood fibers	986:1007	unmodified wood fibers	986:1007	Besides, the flame retardancy smoldering effects may also be reduced compared to unmodified wood fibers depending on the used biopolymer.
33158075	11	21	theme	different	1067:1075	arg1	biopolymers					1077:1087	different biopolymers	1067:1087	different biopolymers modified in phosphate/urea systems	1067:1122	These results show that different biopolymers modified in phosphate/urea systems are a serious alternative to conventional flame retardants.
33158075	11	21	theme	different	1067:1075	arg1	alternative					1138:1148	a serious alternative	1128:1148	a serious alternative to conventional flame retardants	1128:1181	These results show that different biopolymers modified in phosphate/urea systems are a serious alternative to conventional flame retardants.
33158075	0	22	theme	Renewable	42:50	arg1	Materials					52:60	Different Renewable Materials	32:60	Different Renewable Materials	32:60	Suitability and Modification of Different Renewable Materials as Feedstock for Sustainable Flame Retardants.
33158075	10	23	theme	unmodified	986:995	arg1	fibers					1002:1007	unmodified wood fibers	986:1007	unmodified wood fibers	986:1007	Besides, the flame retardancy smoldering effects may also be reduced compared to unmodified wood fibers depending on the used biopolymer.
33158075	0	24	theme	Different	32:40	arg1	Materials					52:60	Different Renewable Materials	32:60	Different Renewable Materials	32:60	Suitability and Modification of Different Renewable Materials as Feedstock for Sustainable Flame Retardants.
33158075	8	25	theme	wood	691:694	arg1	fibers					696:701	wood fibers	691:701	wood fibers	691:701	The derivatives were applied on wood fibers and tested as flame retardants.
33158075	9	26	theme	commercial	841:850	arg1	performances					825:836	the same flame-retardant performances	800:836	the same flame-retardant performances	800:836	The results indicate that these modified biopolymers can provide the same flame-retardant performances as commercial compounds currently used in the wood fiber industry.
33158075	9	26	theme	commercial	841:850	arg1	compounds					852:860	commercial compounds	841:860	commercial compounds currently used in the wood fiber industry	841:902	The results indicate that these modified biopolymers can provide the same flame-retardant performances as commercial compounds currently used in the wood fiber industry.
33158075	10	27	theme	smoldering	935:944	arg1	effects					946:952	the flame retardancy smoldering effects	914:952	the flame retardancy smoldering effects	914:952	Besides, the flame retardancy smoldering effects may also be reduced compared to unmodified wood fibers depending on the used biopolymer.
33158075	5	28	dep	48	620:621	arg1	to					617:618	to	617:618	to	617:618	The functionalization leads to the incorporation of phosphates (up to 48 wt.
33158075	4	29	from	salts	528:532	arg1	urea					544:547	molten urea	537:547	molten urea	537:547	Wheat starch, wheat protein, xylan and tannin were modified with phosphate salts in molten urea.
33158075	4	30	theme	wheat	467:471	arg1	protein					473:479	wheat protein	467:479	wheat protein	467:479	Wheat starch, wheat protein, xylan and tannin were modified with phosphate salts in molten urea.
33158075	10	31	theme	retardancy	924:933	arg1	effects					946:952	the flame retardancy smoldering effects	914:952	the flame retardancy smoldering effects	914:952	Besides, the flame retardancy smoldering effects may also be reduced compared to unmodified wood fibers depending on the used biopolymer.
33158075	3	32	theme	main	428:431	arg1	research					350:357	research	350:357	research on innovative flame retardants based on sustainable materials	350:419	For this reason, research on innovative flame retardants based on sustainable materials is the main focus of this work.
33158075	3	32	theme	main	428:431	arg1	focus					433:437	the main focus	424:437	the main focus of this work	424:450	For this reason, research on innovative flame retardants based on sustainable materials is the main focus of this work.
33158075	1	33	dep	toxic	182:186	arg1	biodegradable					196:208	biodegradable	196:208	biodegradable	196:208	Due to their chemical structure, conventional flame retardants are often toxic, barely biodegradable and consequently neither healthy nor environmentally friendly.
33158075	1	34	theme	chemical	122:129	arg1	structure					131:139	their chemical structure	116:139	their chemical structure	116:139	Due to their chemical structure, conventional flame retardants are often toxic, barely biodegradable and consequently neither healthy nor environmentally friendly.
33158075	4	35	theme	molten	537:542	arg1	urea					544:547	molten urea	537:547	molten urea	537:547	Wheat starch, wheat protein, xylan and tannin were modified with phosphate salts in molten urea.
33158075	11	36	theme	phosphate/urea	1101:1114	arg1	systems					1116:1122	phosphate/urea systems	1101:1122	phosphate/urea systems	1101:1122	These results show that different biopolymers modified in phosphate/urea systems are a serious alternative to conventional flame retardants.
33158075	1	37	theme	healthy	235:241	arg1	friendly					263:270	neither healthy nor environmentally friendly	227:270	neither healthy nor environmentally friendly	227:270	Due to their chemical structure, conventional flame retardants are often toxic, barely biodegradable and consequently neither healthy nor environmentally friendly.
33158075	4	38	theme	Wheat	453:457	arg1	starch					459:464	Wheat starch	453:464	Wheat starch	453:464	Wheat starch, wheat protein, xylan and tannin were modified with phosphate salts in molten urea.
33158075	11	39	theme	serious	1130:1136	arg1	alternative					1138:1148	a serious alternative	1128:1148	a serious alternative to conventional flame retardants	1128:1181	These results show that different biopolymers modified in phosphate/urea systems are a serious alternative to conventional flame retardants.
33158075	11	39	theme	serious	1130:1136	arg1	biopolymers					1077:1087	different biopolymers	1067:1087	different biopolymers modified in phosphate/urea systems	1067:1122	These results show that different biopolymers modified in phosphate/urea systems are a serious alternative to conventional flame retardants.
33158075	5	40	dep	phosphates	602:611	arg1	wt					623:624	up to 48 wt	614:624	up to 48 wt	614:624	The functionalization leads to the incorporation of phosphates (up to 48 wt.
33158075	1	41	theme	conventional	142:153	arg1	retardants					161:170	conventional flame retardants	142:170	conventional flame retardants	142:170	Due to their chemical structure, conventional flame retardants are often toxic, barely biodegradable and consequently neither healthy nor environmentally friendly.
33158075	1	42	theme	environmentally	247:261	arg1	friendly					263:270	neither healthy nor environmentally friendly	227:270	neither healthy nor environmentally friendly	227:270	Due to their chemical structure, conventional flame retardants are often toxic, barely biodegradable and consequently neither healthy nor environmentally friendly.
33158075	9	43	theme	wood	884:887	arg1	industry					895:902	the wood fiber industry	880:902	the wood fiber industry	880:902	The results indicate that these modified biopolymers can provide the same flame-retardant performances as commercial compounds currently used in the wood fiber industry.
33158075	1	44	theme	flame	155:159	arg1	retardants					161:170	conventional flame retardants	142:170	conventional flame retardants	142:170	Due to their chemical structure, conventional flame retardants are often toxic, barely biodegradable and consequently neither healthy nor environmentally friendly.
33158075	8	45	theme	flame	717:721	arg1	retardants					723:732	flame retardants	717:732	flame retardants	717:732	The derivatives were applied on wood fibers and tested as flame retardants.
33158075	8	45	theme	flame	717:721	arg1	derivatives					663:673	The derivatives	659:673	The derivatives	659:673	The derivatives were applied on wood fibers and tested as flame retardants.
33571209	13	0	theme	gene	1927:1930	arg1	HGT					1942:1944	HGT	1942:1944	HGT	1942:1944	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	13	0	theme	gene	1927:1930	arg1	transfer					1932:1939	horizontal gene transfer	1916:1939	multiple horizontal gene transfer (HGT) events	1907:1952	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	7	1	theme	outer	1221:1225	arg1	surface					1227:1233	the outer surface	1217:1233	the outer surface of Dickeya	1217:1244	These gene clusters are key regulatory components in the composition and structure of the outer surface of Dickeya.
33571209	2	2	theme	regulation	380:389	arg1	processes					343:351	complex multi-factorial processes	319:351	complex multi-factorial processes of adaptive virulence gene regulation	319:389	Their pathogenicity is governed by complex multi-factorial processes of adaptive virulence gene regulation.
33571209	8	3	theme	O-antigen	1251:1259	arg1	region					1298:1303	The O-antigen capsule/group 4 capsule (G4C) coding region	1247:1303	The O-antigen capsule/group 4 capsule (G4C) coding region	1247:1303	The O-antigen capsule/group 4 capsule (G4C) coding region shows a variation in gene content and organization.
33571209	4	4	theme	polysaccharide	647:660	arg1	diversity					612:620	diversity	612:620	diversity	612:620	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	4	4	theme	polysaccharide	647:660	arg1	organization					627:638	organization	627:638	organization	627:638	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	4	4	theme	polysaccharide	647:660	arg1	location					602:609	the genomic location	590:609	the genomic location	590:609	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	14	5	gly	heterogeneity	2028:2040	arg1	capsules					2055:2062	O-antigen capsules	2045:2062	O-antigen capsules	2045:2062	These multiple HGT processes might have been manifested into the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution.
33571209	14	5	gly	heterogeneity	2028:2040	arg1	lipopolysaccharides					2078:2096	O-antigen lipopolysaccharides	2068:2096	O-antigen lipopolysaccharides	2068:2096	These multiple HGT processes might have been manifested into the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution.
33571209	14	6	theme	multiple	1961:1968	arg1	processes					1974:1982	These multiple HGT processes	1955:1982	These multiple HGT processes	1955:1982	These multiple HGT processes might have been manifested into the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution.
33571209	0	7	theme	Genomic	0:6	arg1	diversity					8:16	Genomic diversity	0:16	Genomic diversity	0:16	Genomic diversity and organization of complex polysaccharide biosynthesis clusters in the genus Dickeya.
33571209	1	8	theme	pathogenic	187:196	arg1	species					198:204	numerous pathogenic species	178:204	numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe	178:281	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	2	9	theme	multi-factorial	327:341	arg1	processes					343:351	complex multi-factorial processes	319:351	complex multi-factorial processes of adaptive virulence gene regulation	319:389	Their pathogenicity is governed by complex multi-factorial processes of adaptive virulence gene regulation.
33571209	12	10	theme	core	1667:1670	arg1	biosynthesis					1691:1702	core lipopolysaccharide biosynthesis	1667:1702	core lipopolysaccharide biosynthesis	1667:1702	Also, enterobacterial common antigen and core lipopolysaccharide biosynthesis clusters are present mostly as conserved genomic regions.
33571209	4	11	dep	polysaccharide	647:660	arg1	the					643:645	the	643:645	the	643:645	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	4	11	dep	polysaccharide	647:660	arg1	clusters					703:710	biosynthetic gene clusters	685:710	biosynthetic gene clusters	685:710	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	5	12	theme	antigen	908:914	arg1	diversity					760:768	the diversity	756:768	the diversity	756:768	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	5	12	theme	antigen	908:914	arg1	clusters					958:965	putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters	846:965	putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains	846:989	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	12	13	theme	biosynthesis	1691:1702	arg1	clusters					1704:1711	enterobacterial common antigen and core lipopolysaccharide biosynthesis clusters	1632:1711	enterobacterial common antigen and core lipopolysaccharide biosynthesis clusters	1632:1711	Also, enterobacterial common antigen and core lipopolysaccharide biosynthesis clusters are present mostly as conserved genomic regions.
33571209	13	14	theme	lipopolysaccharide	1824:1841	arg1	region					1850:1855	putative O-antigen lipopolysaccharide coding region	1805:1855	putative O-antigen lipopolysaccharide coding region	1805:1855	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	7	15	theme	key	1155:1157	arg1	clusters					1142:1149	These gene clusters	1131:1149	These gene clusters	1131:1149	These gene clusters are key regulatory components in the composition and structure of the outer surface of Dickeya.
33571209	7	15	theme	key	1155:1157	arg1	components					1170:1179	key regulatory components	1155:1179	key regulatory components in the composition and structure of the outer surface of Dickeya	1155:1244	These gene clusters are key regulatory components in the composition and structure of the outer surface of Dickeya.
33571209	1	16	theme	various	230:236	arg1	crops					238:242	various crops	230:242	various crops	230:242	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	12	17	theme	enterobacterial	1632:1646	arg1	antigen					1655:1661	enterobacterial common antigen	1632:1661	enterobacterial common antigen	1632:1661	Also, enterobacterial common antigen and core lipopolysaccharide biosynthesis clusters are present mostly as conserved genomic regions.
33571209	12	18	theme	antigen	1655:1661	arg1	clusters					1704:1711	enterobacterial common antigen and core lipopolysaccharide biosynthesis clusters	1632:1711	enterobacterial common antigen and core lipopolysaccharide biosynthesis clusters	1632:1711	Also, enterobacterial common antigen and core lipopolysaccharide biosynthesis clusters are present mostly as conserved genomic regions.
33571209	3	19	attach	present	446:452	arg2	polysaccharides					406:420	Extracellular polysaccharides	392:420	Extracellular polysaccharides	392:420	Extracellular polysaccharides and lipopolysaccharides present on bacterial envelope surface play a significant role in the virulence of phytopathogenic bacteria.
33571209	3	19	attach	present	446:452	arg1	surface					476:482	bacterial envelope surface	457:482	bacterial envelope surface	457:482	Extracellular polysaccharides and lipopolysaccharides present on bacterial envelope surface play a significant role in the virulence of phytopathogenic bacteria.
33571209	1	20	from	diseases	218:225	arg1	crops					238:242	various crops	230:242	various crops	230:242	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	1	20	from	diseases	218:225	arg1	plants					259:264	ornamental plants	248:264	ornamental plants	248:264	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	1	21	theme	ornamental	248:257	arg1	plants					259:264	ornamental plants	248:264	ornamental plants	248:264	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	14	22	from	heterogeneity	2028:2040	arg1	strains					2109:2115	Dickeya strains	2101:2115	Dickeya strains during its evolution	2101:2136	These multiple HGT processes might have been manifested into the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution.
33571209	1	23	theme	formerly	137:144	arg1	chrysanthemi					154:165	formerly Erwinia chrysanthemi	137:165	formerly Erwinia chrysanthemi	137:165	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	1	23	theme	formerly	137:144	arg1	Dickeya					128:134	The pectinolytic genus Dickeya	105:134	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi)	105:166	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	6	24	theme	external	1113:1120	arg1	surface					1122:1128	their external surface	1107:1128	their external surface	1107:1128	The presence of these clusters suggests that Dickeya has both capsule and lipopolysaccharide carrying O-antigen to their external surface.
33571209	0	25	theme	clusters	74:81	arg1	organization					22:33	organization	22:33	organization	22:33	Genomic diversity and organization of complex polysaccharide biosynthesis clusters in the genus Dickeya.
33571209	0	25	theme	clusters	74:81	arg1	diversity					8:16	Genomic diversity	0:16	Genomic diversity	0:16	Genomic diversity and organization of complex polysaccharide biosynthesis clusters in the genus Dickeya.
33571209	13	26	theme	O-antigen	1783:1791	arg1	capsule					1793:1799	the O-antigen capsule	1779:1799	the O-antigen capsule	1779:1799	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	9	27	theme	sequence	1377:1384	arg1	homology					1386:1393	nucleotide sequence homology	1366:1393	nucleotide sequence homology in these Dickeya strains	1366:1418	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	3	28	theme	Extracellular	392:404	arg1	polysaccharides					406:420	Extracellular polysaccharides	392:420	Extracellular polysaccharides	392:420	Extracellular polysaccharides and lipopolysaccharides present on bacterial envelope surface play a significant role in the virulence of phytopathogenic bacteria.
33571209	12	29	theme	genomic	1745:1751	arg1	regions					1753:1759	conserved genomic regions	1735:1759	conserved genomic regions	1735:1759	Also, enterobacterial common antigen and core lipopolysaccharide biosynthesis clusters are present mostly as conserved genomic regions.
33571209	4	30	from	organization	627:638	arg1	Dickeya					715:721	Dickeya	715:721	Dickeya	715:721	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	9	31	theme	Dickeya	1404:1410	arg1	strains					1412:1418	these Dickeya strains	1398:1418	these Dickeya strains	1398:1418	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	4	32	from	location	602:609	arg1	Dickeya					715:721	Dickeya	715:721	Dickeya	715:721	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	3	33	theme	present	446:452	arg1	polysaccharides					406:420	Extracellular polysaccharides	392:420	Extracellular polysaccharides	392:420	Extracellular polysaccharides and lipopolysaccharides present on bacterial envelope surface play a significant role in the virulence of phytopathogenic bacteria.
33571209	5	34	theme	lipopolysaccharide	865:882	arg1	diversity					760:768	the diversity	756:768	the diversity	756:768	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	5	34	theme	lipopolysaccharide	865:882	arg1	clusters					958:965	putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters	846:965	putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains	846:989	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	6	35	contain	carrying	1085:1092	arg2	O-antigen					1094:1102	O-antigen	1094:1102	O-antigen	1094:1102	The presence of these clusters suggests that Dickeya has both capsule and lipopolysaccharide carrying O-antigen to their external surface.
33571209	6	35	contain	carrying	1085:1092	arg1	capsule					1054:1060	capsule	1054:1060	capsule	1054:1060	The presence of these clusters suggests that Dickeya has both capsule and lipopolysaccharide carrying O-antigen to their external surface.
33571209	5	36	theme	enterobacterial	885:899	arg1	antigen					908:914	enterobacterial common antigen	885:914	enterobacterial common antigen	885:914	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	9	37	theme	distinct	1425:1432	arg1	groups					1434:1439	two distinct groups	1421:1439	two distinct groups	1421:1439	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	9	37	theme	distinct	1425:1432	arg1	II					1468:1469	G4C group II	1458:1469	G4C group II	1458:1469	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	9	37	theme	distinct	1425:1432	arg1	I					1452:1452	G4C group I	1442:1452	G4C group I	1442:1452	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	1	38	theme	pectinolytic	109:120	arg1	chrysanthemi					154:165	formerly Erwinia chrysanthemi	137:165	formerly Erwinia chrysanthemi	137:165	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	1	38	theme	pectinolytic	109:120	arg1	Dickeya					128:134	The pectinolytic genus Dickeya	105:134	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi)	105:166	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	10	39	theme	O-antigen	1545:1553	arg1	cluster					1574:1580	the putative O-antigen lipopolysaccharide cluster	1532:1580	the putative O-antigen lipopolysaccharide cluster in Dickeya spp	1532:1595	However, comparatively less variation is observed in the putative O-antigen lipopolysaccharide cluster in Dickeya spp.
33571209	5	40	theme	core	921:924	arg1	lipopolysaccharide					926:943	core lipopolysaccharide	921:943	core lipopolysaccharide	921:943	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	5	41	theme	capsule	837:843	arg1	clusters					958:965	putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters	846:965	putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains	846:989	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	5	41	theme	capsule	837:843	arg1	diversity					760:768	the diversity	756:768	the diversity	756:768	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	5	41	theme	capsule	837:843	arg1	organization					785:796	structural organization	774:796	structural organization	774:796	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	14	42	theme	O-antigen	2068:2076	arg1	lipopolysaccharides					2078:2096	O-antigen lipopolysaccharides	2068:2096	O-antigen lipopolysaccharides	2068:2096	These multiple HGT processes might have been manifested into the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution.
33571209	3	43	theme	bacterial	457:465	arg1	surface					476:482	bacterial envelope surface	457:482	bacterial envelope surface	457:482	Extracellular polysaccharides and lipopolysaccharides present on bacterial envelope surface play a significant role in the virulence of phytopathogenic bacteria.
33571209	2	44	theme	gene	375:378	arg1	regulation					380:389	adaptive virulence gene regulation	356:389	adaptive virulence gene regulation	356:389	Their pathogenicity is governed by complex multi-factorial processes of adaptive virulence gene regulation.
33571209	5	45	theme	putative	846:853	arg1	lipopolysaccharide					865:882	putative O-antigen lipopolysaccharide	846:882	putative O-antigen lipopolysaccharide	846:882	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	9	46	theme	group	1446:1450	arg1	groups					1434:1439	two distinct groups	1421:1439	two distinct groups	1421:1439	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	9	46	theme	group	1446:1450	arg1	I					1452:1452	G4C group I	1442:1452	G4C group I	1442:1452	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	14	47	theme	capsules	2055:2062	arg1	heterogeneity					2028:2040	the current heterogeneity	2016:2040	the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution	2016:2136	These multiple HGT processes might have been manifested into the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution.
33571209	4	48	theme	genomic	594:600	arg1	location					602:609	the genomic location	590:609	the genomic location	590:609	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	2	49	theme	adaptive	356:363	arg1	regulation					380:389	adaptive virulence gene regulation	356:389	adaptive virulence gene regulation	356:389	Their pathogenicity is governed by complex multi-factorial processes of adaptive virulence gene regulation.
33571209	5	50	theme	lipopolysaccharide	926:943	arg1	diversity					760:768	the diversity	756:768	the diversity	756:768	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	5	50	theme	lipopolysaccharide	926:943	arg1	clusters					958:965	putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters	846:965	putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains	846:989	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	9	51	theme	group	1462:1466	arg1	II					1468:1469	G4C group II	1458:1469	G4C group II	1458:1469	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	9	51	theme	group	1462:1466	arg1	groups					1434:1439	two distinct groups	1421:1439	two distinct groups	1421:1439	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	0	52	theme	biosynthesis	61:72	arg1	clusters					74:81	complex polysaccharide biosynthesis clusters	38:81	complex polysaccharide biosynthesis clusters	38:81	Genomic diversity and organization of complex polysaccharide biosynthesis clusters in the genus Dickeya.
33571209	14	53	theme	current	2020:2026	arg1	heterogeneity					2028:2040	the current heterogeneity	2016:2040	the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution	2016:2136	These multiple HGT processes might have been manifested into the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution.
33571209	4	54	theme	biosynthetic	685:696	arg1	clusters					703:710	biosynthetic gene clusters	685:710	biosynthetic gene clusters	685:710	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	13	55	theme	horizontal	1916:1925	arg1	HGT					1942:1944	HGT	1942:1944	HGT	1942:1944	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	13	55	theme	horizontal	1916:1925	arg1	transfer					1932:1939	horizontal gene transfer	1916:1939	multiple horizontal gene transfer (HGT) events	1907:1952	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	5	56	theme	G4C	822:824	arg1	capsule					837:843	the group 4 capsule (G4C)/O-antigen capsule	801:843	the group 4 capsule (G4C)/O-antigen capsule	801:843	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	13	57	from	region	1850:1855	arg1	capsule					1793:1799	the O-antigen capsule	1779:1799	the O-antigen capsule	1779:1799	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	13	57	from	region	1850:1855	arg1	relation					1860:1867	relation	1860:1867	relation to their phylogeny	1860:1886	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	5	58	theme	present	731:737	arg1	study					739:743	the present study	727:743	the present study	727:743	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	11	59	theme	Dickeya	1612:1618	arg1	zeae					1620:1623	Dickeya zeae	1612:1623	Dickeya zeae	1612:1623	except for in Dickeya zeae.
33571209	7	60	from	components	1170:1179	arg1	composition					1188:1198	composition	1188:1198	composition	1188:1198	These gene clusters are key regulatory components in the composition and structure of the outer surface of Dickeya.
33571209	7	60	from	components	1170:1179	arg1	structure					1204:1212	structure	1204:1212	structure	1204:1212	These gene clusters are key regulatory components in the composition and structure of the outer surface of Dickeya.
33571209	1	61	theme	numerous	178:185	arg1	species					198:204	numerous pathogenic species	178:204	numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe	178:281	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	8	62	theme	capsule/group	1261:1273	arg1	region					1298:1303	The O-antigen capsule/group 4 capsule (G4C) coding region	1247:1303	The O-antigen capsule/group 4 capsule (G4C) coding region	1247:1303	The O-antigen capsule/group 4 capsule (G4C) coding region shows a variation in gene content and organization.
33571209	5	63	theme	biosynthesis	945:956	arg1	diversity					760:768	the diversity	756:768	the diversity	756:768	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	5	63	theme	biosynthesis	945:956	arg1	clusters					958:965	putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters	846:965	putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains	846:989	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	8	64	theme	capsule	1277:1283	arg1	region					1298:1303	The O-antigen capsule/group 4 capsule (G4C) coding region	1247:1303	The O-antigen capsule/group 4 capsule (G4C) coding region	1247:1303	The O-antigen capsule/group 4 capsule (G4C) coding region shows a variation in gene content and organization.
33571209	12	65	theme	lipopolysaccharide	1672:1689	arg1	biosynthesis					1691:1702	core lipopolysaccharide biosynthesis	1667:1702	core lipopolysaccharide biosynthesis	1667:1702	Also, enterobacterial common antigen and core lipopolysaccharide biosynthesis clusters are present mostly as conserved genomic regions.
33571209	0	66	theme	polysaccharide	46:59	arg1	clusters					74:81	complex polysaccharide biosynthesis clusters	38:81	complex polysaccharide biosynthesis clusters	38:81	Genomic diversity and organization of complex polysaccharide biosynthesis clusters in the genus Dickeya.
33571209	10	67	located	observed	1520:1527	arg1	cluster					1574:1580	the putative O-antigen lipopolysaccharide cluster	1532:1580	the putative O-antigen lipopolysaccharide cluster in Dickeya spp	1532:1595	However, comparatively less variation is observed in the putative O-antigen lipopolysaccharide cluster in Dickeya spp.
33571209	10	67	located	observed	1520:1527	arg2	variation					1507:1515	comparatively less variation	1488:1515	comparatively less variation	1488:1515	However, comparatively less variation is observed in the putative O-antigen lipopolysaccharide cluster in Dickeya spp.
33571209	7	68	theme	regulatory	1159:1168	arg1	clusters					1142:1149	These gene clusters	1131:1149	These gene clusters	1131:1149	These gene clusters are key regulatory components in the composition and structure of the outer surface of Dickeya.
33571209	7	68	theme	regulatory	1159:1168	arg1	components					1170:1179	key regulatory components	1155:1179	key regulatory components in the composition and structure of the outer surface of Dickeya	1155:1244	These gene clusters are key regulatory components in the composition and structure of the outer surface of Dickeya.
33571209	2	69	theme	complex	319:325	arg1	processes					343:351	complex multi-factorial processes	319:351	complex multi-factorial processes of adaptive virulence gene regulation	319:389	Their pathogenicity is governed by complex multi-factorial processes of adaptive virulence gene regulation.
33571209	5	70	theme	common	901:906	arg1	antigen					908:914	enterobacterial common antigen	885:914	enterobacterial common antigen	885:914	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	8	71	theme	G4C	1286:1288	arg1	region					1298:1303	The O-antigen capsule/group 4 capsule (G4C) coding region	1247:1303	The O-antigen capsule/group 4 capsule (G4C) coding region	1247:1303	The O-antigen capsule/group 4 capsule (G4C) coding region shows a variation in gene content and organization.
33571209	13	72	theme	O-antigen	1814:1822	arg1	region					1850:1855	putative O-antigen lipopolysaccharide coding region	1805:1855	putative O-antigen lipopolysaccharide coding region	1805:1855	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	5	73	theme	structural	774:783	arg1	organization					785:796	structural organization	774:796	structural organization	774:796	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	8	74	theme	gene	1326:1329	arg1	content					1331:1337	gene content	1326:1337	gene content	1326:1337	The O-antigen capsule/group 4 capsule (G4C) coding region shows a variation in gene content and organization.
33571209	9	75	from	homology	1386:1393	arg1	strains					1412:1418	these Dickeya strains	1398:1418	these Dickeya strains	1398:1418	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	12	76	theme	common	1648:1653	arg1	antigen					1655:1661	enterobacterial common antigen	1632:1661	enterobacterial common antigen	1632:1661	Also, enterobacterial common antigen and core lipopolysaccharide biosynthesis clusters are present mostly as conserved genomic regions.
33571209	13	77	theme	coding	1843:1848	arg1	region					1850:1855	putative O-antigen lipopolysaccharide coding region	1805:1855	putative O-antigen lipopolysaccharide coding region	1805:1855	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	7	78	theme	gene	1137:1140	arg1	clusters					1142:1149	These gene clusters	1131:1149	These gene clusters	1131:1149	These gene clusters are key regulatory components in the composition and structure of the outer surface of Dickeya.
33571209	7	78	theme	gene	1137:1140	arg1	components					1170:1179	key regulatory components	1155:1179	key regulatory components in the composition and structure of the outer surface of Dickeya	1155:1244	These gene clusters are key regulatory components in the composition and structure of the outer surface of Dickeya.
33571209	1	79	theme	genus	122:126	arg1	chrysanthemi					154:165	formerly Erwinia chrysanthemi	137:165	formerly Erwinia chrysanthemi	137:165	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	1	79	theme	genus	122:126	arg1	Dickeya					128:134	The pectinolytic genus Dickeya	105:134	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi)	105:166	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	6	80	theme	clusters	1014:1021	arg1	presence					996:1003	The presence	992:1003	The presence of these clusters	992:1021	The presence of these clusters suggests that Dickeya has both capsule and lipopolysaccharide carrying O-antigen to their external surface.
33571209	8	81	from	variation	1313:1321	arg1	organization					1343:1354	organization	1343:1354	organization	1343:1354	The O-antigen capsule/group 4 capsule (G4C) coding region shows a variation in gene content and organization.
33571209	8	81	from	variation	1313:1321	arg1	content					1331:1337	gene content	1326:1337	gene content	1326:1337	The O-antigen capsule/group 4 capsule (G4C) coding region shows a variation in gene content and organization.
33571209	0	82	theme	complex	38:44	arg1	clusters					74:81	complex polysaccharide biosynthesis clusters	38:81	complex polysaccharide biosynthesis clusters	38:81	Genomic diversity and organization of complex polysaccharide biosynthesis clusters in the genus Dickeya.
33571209	3	83	theme	bacteria	544:551	arg1	virulence					515:523	the virulence	511:523	the virulence of phytopathogenic bacteria	511:551	Extracellular polysaccharides and lipopolysaccharides present on bacterial envelope surface play a significant role in the virulence of phytopathogenic bacteria.
33571209	5	84	theme	capsule	813:819	arg1	capsule					837:843	the group 4 capsule (G4C)/O-antigen capsule	801:843	the group 4 capsule (G4C)/O-antigen capsule	801:843	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	1	85	theme	Erwinia	146:152	arg1	chrysanthemi					154:165	formerly Erwinia chrysanthemi	137:165	formerly Erwinia chrysanthemi	137:165	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	1	85	theme	Erwinia	146:152	arg1	Dickeya					128:134	The pectinolytic genus Dickeya	105:134	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi)	105:166	The pectinolytic genus Dickeya (formerly Erwinia chrysanthemi) comprises numerous pathogenic species which cause diseases in various crops and ornamental plants across the globe.
33571209	10	86	from	cluster	1574:1580	arg1	Dickeya					1585:1591	Dickeya	1585:1591	Dickeya	1585:1591	However, comparatively less variation is observed in the putative O-antigen lipopolysaccharide cluster in Dickeya spp.
33571209	0	87	from	organization	22:33	arg1	Dickeya					96:102	the genus Dickeya	86:102	the genus Dickeya	86:102	Genomic diversity and organization of complex polysaccharide biosynthesis clusters in the genus Dickeya.
33571209	0	88	theme	genus	90:94	arg1	Dickeya					96:102	the genus Dickeya	86:102	the genus Dickeya	86:102	Genomic diversity and organization of complex polysaccharide biosynthesis clusters in the genus Dickeya.
33571209	9	89	theme	nucleotide	1366:1375	arg1	homology					1386:1393	nucleotide sequence homology	1366:1393	nucleotide sequence homology in these Dickeya strains	1366:1418	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	5	90	theme	Dickeya	975:981	arg1	strains					983:989	54 Dickeya strains	972:989	54 Dickeya strains	972:989	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	0	91	from	diversity	8:16	arg1	Dickeya					96:102	the genus Dickeya	86:102	the genus Dickeya	86:102	Genomic diversity and organization of complex polysaccharide biosynthesis clusters in the genus Dickeya.
33571209	10	92	theme	less	1502:1505	arg1	variation					1507:1515	comparatively less variation	1488:1515	comparatively less variation	1488:1515	However, comparatively less variation is observed in the putative O-antigen lipopolysaccharide cluster in Dickeya spp.
33571209	5	93	from	strains	983:989	arg1	diversity					760:768	the diversity	756:768	the diversity	756:768	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	5	93	from	strains	983:989	arg1	clusters					958:965	putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters	846:965	putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains	846:989	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	13	94	theme	putative	1805:1812	arg1	region					1850:1855	putative O-antigen lipopolysaccharide coding region	1805:1855	putative O-antigen lipopolysaccharide coding region	1805:1855	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	13	95	theme	events	1947:1952	arg1	role					1899:1902	a role	1897:1902	a role of multiple horizontal gene transfer (HGT) events	1897:1952	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	5	96	theme	group	805:809	arg1	capsule					837:843	the group 4 capsule (G4C)/O-antigen capsule	801:843	the group 4 capsule (G4C)/O-antigen capsule	801:843	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	12	97	theme	conserved	1735:1743	arg1	regions					1753:1759	conserved genomic regions	1735:1759	conserved genomic regions	1735:1759	Also, enterobacterial common antigen and core lipopolysaccharide biosynthesis clusters are present mostly as conserved genomic regions.
33571209	10	98	theme	putative	1536:1543	arg1	cluster					1574:1580	the putative O-antigen lipopolysaccharide cluster	1532:1580	the putative O-antigen lipopolysaccharide cluster in Dickeya spp	1532:1595	However, comparatively less variation is observed in the putative O-antigen lipopolysaccharide cluster in Dickeya spp.
33571209	5	99	theme	O-antigen	855:863	arg1	lipopolysaccharide					865:882	putative O-antigen lipopolysaccharide	846:882	putative O-antigen lipopolysaccharide	846:882	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	13	100	theme	transfer	1932:1939	arg1	events					1947:1952	multiple horizontal gene transfer (HGT) events	1907:1952	multiple horizontal gene transfer (HGT) events	1907:1952	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	3	101	theme	significant	491:501	arg1	role					503:506	a significant role	489:506	a significant role	489:506	Extracellular polysaccharides and lipopolysaccharides present on bacterial envelope surface play a significant role in the virulence of phytopathogenic bacteria.
33571209	4	102	from	diversity	612:620	arg1	Dickeya					715:721	Dickeya	715:721	Dickeya	715:721	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	14	103	theme	Dickeya	2101:2107	arg1	strains					2109:2115	Dickeya strains	2101:2115	Dickeya strains during its evolution	2101:2136	These multiple HGT processes might have been manifested into the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution.
33571209	10	104	theme	lipopolysaccharide	1555:1572	arg1	cluster					1574:1580	the putative O-antigen lipopolysaccharide cluster	1532:1580	the putative O-antigen lipopolysaccharide cluster in Dickeya spp	1532:1595	However, comparatively less variation is observed in the putative O-antigen lipopolysaccharide cluster in Dickeya spp.
33571209	3	105	theme	phytopathogenic	528:542	arg1	bacteria					544:551	phytopathogenic bacteria	528:551	phytopathogenic bacteria	528:551	Extracellular polysaccharides and lipopolysaccharides present on bacterial envelope surface play a significant role in the virulence of phytopathogenic bacteria.
33571209	7	106	theme	Dickeya	1238:1244	arg1	surface					1227:1233	the outer surface	1217:1233	the outer surface of Dickeya	1217:1244	These gene clusters are key regulatory components in the composition and structure of the outer surface of Dickeya.
33571209	13	107	from	variation	1766:1774	arg1	capsule					1793:1799	the O-antigen capsule	1779:1799	the O-antigen capsule	1779:1799	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	13	107	from	variation	1766:1774	arg1	relation					1860:1867	relation	1860:1867	relation to their phylogeny	1860:1886	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
33571209	14	108	theme	lipopolysaccharides	2078:2096	arg1	heterogeneity					2028:2040	the current heterogeneity	2016:2040	the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution	2016:2136	These multiple HGT processes might have been manifested into the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution.
33571209	8	109	theme	coding	1291:1296	arg1	region					1298:1303	The O-antigen capsule/group 4 capsule (G4C) coding region	1247:1303	The O-antigen capsule/group 4 capsule (G4C) coding region	1247:1303	The O-antigen capsule/group 4 capsule (G4C) coding region shows a variation in gene content and organization.
33571209	6	110	contain	has	1045:1047	arg2	capsule					1054:1060	capsule	1054:1060	capsule	1054:1060	The presence of these clusters suggests that Dickeya has both capsule and lipopolysaccharide carrying O-antigen to their external surface.
33571209	6	110	contain	has	1045:1047	arg2	lipopolysaccharide					1066:1083	lipopolysaccharide	1066:1083	lipopolysaccharide	1066:1083	The presence of these clusters suggests that Dickeya has both capsule and lipopolysaccharide carrying O-antigen to their external surface.
33571209	6	110	contain	has	1045:1047	arg1	Dickeya					1037:1043	Dickeya	1037:1043	Dickeya	1037:1043	The presence of these clusters suggests that Dickeya has both capsule and lipopolysaccharide carrying O-antigen to their external surface.
33571209	7	111	theme	surface	1227:1233	arg1	composition					1188:1198	composition	1188:1198	composition	1188:1198	These gene clusters are key regulatory components in the composition and structure of the outer surface of Dickeya.
33571209	7	111	theme	surface	1227:1233	arg1	structure					1204:1212	structure	1204:1212	structure	1204:1212	These gene clusters are key regulatory components in the composition and structure of the outer surface of Dickeya.
33571209	9	112	theme	G4C	1442:1444	arg1	groups					1434:1439	two distinct groups	1421:1439	two distinct groups	1421:1439	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	9	112	theme	G4C	1442:1444	arg1	I					1452:1452	G4C group I	1442:1452	G4C group I	1442:1452	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	3	113	theme	envelope	467:474	arg1	surface					476:482	bacterial envelope surface	457:482	bacterial envelope surface	457:482	Extracellular polysaccharides and lipopolysaccharides present on bacterial envelope surface play a significant role in the virulence of phytopathogenic bacteria.
33571209	2	114	theme	virulence	365:373	arg1	regulation					380:389	adaptive virulence gene regulation	356:389	adaptive virulence gene regulation	356:389	Their pathogenicity is governed by complex multi-factorial processes of adaptive virulence gene regulation.
33571209	14	115	theme	O-antigen	2045:2053	arg1	capsules					2055:2062	O-antigen capsules	2045:2062	O-antigen capsules	2045:2062	These multiple HGT processes might have been manifested into the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution.
33571209	4	116	theme	lipopolysaccharide	666:683	arg1	diversity					612:620	diversity	612:620	diversity	612:620	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	4	116	theme	lipopolysaccharide	666:683	arg1	organization					627:638	organization	627:638	organization	627:638	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	4	116	theme	lipopolysaccharide	666:683	arg1	location					602:609	the genomic location	590:609	the genomic location	590:609	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	5	117	theme	/O-antigen	826:835	arg1	capsule					837:843	the group 4 capsule (G4C)/O-antigen capsule	801:843	the group 4 capsule (G4C)/O-antigen capsule	801:843	In the present study, we report the diversity and structural organization of the group 4 capsule (G4C)/O-antigen capsule, putative O-antigen lipopolysaccharide, enterobacterial common antigen, and core lipopolysaccharide biosynthesis clusters from 54 Dickeya strains.
33571209	9	118	theme	G4C	1458:1460	arg1	II					1468:1469	G4C group II	1458:1469	G4C group II	1458:1469	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	9	118	theme	G4C	1458:1460	arg1	groups					1434:1439	two distinct groups	1421:1439	two distinct groups	1421:1439	Based on nucleotide sequence homology in these Dickeya strains, two distinct groups, G4C group I and G4C group II, exist.
33571209	14	119	theme	HGT	1970:1972	arg1	processes					1974:1982	These multiple HGT processes	1955:1982	These multiple HGT processes	1955:1982	These multiple HGT processes might have been manifested into the current heterogeneity of O-antigen capsules and O-antigen lipopolysaccharides in Dickeya strains during its evolution.
33571209	4	120	theme	gene	698:701	arg1	clusters					703:710	biosynthetic gene clusters	685:710	biosynthetic gene clusters	685:710	However, very little is known about the genomic location, diversity, and organization of the polysaccharide and lipopolysaccharide biosynthetic gene clusters in Dickeya.
33571209	13	121	theme	multiple	1907:1914	arg1	events					1947:1952	multiple horizontal gene transfer (HGT) events	1907:1952	multiple horizontal gene transfer (HGT) events	1907:1952	The variation in the O-antigen capsule and putative O-antigen lipopolysaccharide coding region in relation to their phylogeny suggests a role of multiple horizontal gene transfer (HGT) events.
35287883	2	0	theme	erythrocyte	446:456	arg1	absorption					458:467	erythrocyte absorption	446:467	erythrocyte absorption	446:467	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	4	1	theme	greater	826:832	arg1	ability					834:840	a greater ability	824:840	a greater ability to bind clotting factors (Ca2+)	824:872	In addition, the composite sponge promoted more platelet adhesion and activation, and the composite sponge demonstrated a greater ability to bind clotting factors (Ca2+).
35287883	0	2	theme	platelet	81:88	arg1	activation					90:99	platelet activation	81:99	platelet activation	81:99	Chitin/corn stalk pith sponge stimulated hemostasis with erythrocyte absorption, platelet activation, and Ca2+-binding capabilities.
35287883	3	3	theme	lower	648:652	arg1	index					665:669	a much lower blood clot index	641:669	a much lower blood clot index	641:669	In vitro hemostatic analysis indicated that CSP incorporation greatly promoted the coagulation process, with a much lower blood clot index and higher blood clot stability.
35287883	2	4	theme	stalk	322:326	arg1	pith					328:331	corn stalk pith	317:331	corn stalk pith (CSP)	317:337	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	2	4	theme	stalk	322:326	arg1	biomass					308:314	another green biomass	294:314	another green biomass	294:314	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	2	4	theme	stalk	322:326	arg1	CSP					334:336	CSP	334:336	CSP	334:336	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	3	5	theme	blood	654:658	arg1	index					665:669	a much lower blood clot index	641:669	a much lower blood clot index	641:669	In vitro hemostatic analysis indicated that CSP incorporation greatly promoted the coagulation process, with a much lower blood clot index and higher blood clot stability.
35287883	6	6	theme	translational	1115:1127	arg1	potential					1129:1137	the excellent translational potential	1101:1137	the excellent translational potential in clinical settings	1101:1158	This composite hemostatic sponge is sustainable, cost-efficient, and biocompatible, which highlight the excellent translational potential in clinical settings.
35287883	1	7	used	used	155:158	arg2	material					176:183	a hemostatic material	163:183	a hemostatic material in surgical sponges	163:203	Chitin (CT) is widely used as a hemostatic material in surgical sponges, although its efficacy needs improvement to promote the clotting process.
35287883	1	7	used	used	155:158	arg2	CT					141:142	CT	141:142	CT	141:142	Chitin (CT) is widely used as a hemostatic material in surgical sponges, although its efficacy needs improvement to promote the clotting process.
35287883	1	7	used	used	155:158	arg2	Chitin					133:138	Chitin	133:138	Chitin (CT)	133:143	Chitin (CT) is widely used as a hemostatic material in surgical sponges, although its efficacy needs improvement to promote the clotting process.
35287883	3	8	theme	blood	682:686	arg1	stability					693:701	higher blood clot stability	675:701	higher blood clot stability	675:701	In vitro hemostatic analysis indicated that CSP incorporation greatly promoted the coagulation process, with a much lower blood clot index and higher blood clot stability.
35287883	6	9	from	potential	1129:1137	arg1	settings					1151:1158	clinical settings	1142:1158	clinical settings	1142:1158	This composite hemostatic sponge is sustainable, cost-efficient, and biocompatible, which highlight the excellent translational potential in clinical settings.
35287883	3	10	theme	clot	688:691	arg1	stability					693:701	higher blood clot stability	675:701	higher blood clot stability	675:701	In vitro hemostatic analysis indicated that CSP incorporation greatly promoted the coagulation process, with a much lower blood clot index and higher blood clot stability.
35287883	4	11	theme	composite	794:802	arg1	sponge					804:809	the composite sponge	790:809	the composite sponge	790:809	In addition, the composite sponge promoted more platelet adhesion and activation, and the composite sponge demonstrated a greater ability to bind clotting factors (Ca2+).
35287883	6	12	theme	composite	1006:1014	arg1	sponge					1027:1032	This composite hemostatic sponge	1001:1032	This composite hemostatic sponge	1001:1032	This composite hemostatic sponge is sustainable, cost-efficient, and biocompatible, which highlight the excellent translational potential in clinical settings.
35287883	0	13	theme	Ca2+-binding	106:117	arg1	capabilities					119:130	Ca2+-binding capabilities	106:130	Ca2+-binding capabilities	106:130	Chitin/corn stalk pith sponge stimulated hemostasis with erythrocyte absorption, platelet activation, and Ca2+-binding capabilities.
35287883	4	14	theme	composite	721:729	arg1	sponge					731:736	the composite sponge	717:736	the composite sponge	717:736	In addition, the composite sponge promoted more platelet adhesion and activation, and the composite sponge demonstrated a greater ability to bind clotting factors (Ca2+).
35287883	5	15	from	loss	937:940	arg1	injury-model					987:998	a rat liver injury-model	975:998	a rat liver injury-model	975:998	Consistently, it achieved complete hemostasis with less blood loss and a shorter hemostatic time in a rat liver injury-model.
35287883	6	16	theme	hemostatic	1016:1025	arg1	sponge					1027:1032	This composite hemostatic sponge	1001:1032	This composite hemostatic sponge	1001:1032	This composite hemostatic sponge is sustainable, cost-efficient, and biocompatible, which highlight the excellent translational potential in clinical settings.
35287883	0	17	theme	stalk	12:16	arg1	sponge					23:28	Chitin/corn stalk pith sponge	0:28	Chitin/corn stalk pith sponge	0:28	Chitin/corn stalk pith sponge stimulated hemostasis with erythrocyte absorption, platelet activation, and Ca2+-binding capabilities.
35287883	3	18	theme	higher	675:680	arg1	stability					693:701	higher blood clot stability	675:701	higher blood clot stability	675:701	In vitro hemostatic analysis indicated that CSP incorporation greatly promoted the coagulation process, with a much lower blood clot index and higher blood clot stability.
35287883	6	19	theme	excellent	1105:1113	arg1	potential					1129:1137	the excellent translational potential	1101:1137	the excellent translational potential in clinical settings	1101:1158	This composite hemostatic sponge is sustainable, cost-efficient, and biocompatible, which highlight the excellent translational potential in clinical settings.
35287883	1	20	theme	hemostatic	165:174	arg1	material					176:183	a hemostatic material	163:183	a hemostatic material in surgical sponges	163:203	Chitin (CT) is widely used as a hemostatic material in surgical sponges, although its efficacy needs improvement to promote the clotting process.
35287883	1	20	theme	hemostatic	165:174	arg1	Chitin					133:138	Chitin	133:138	Chitin (CT)	133:143	Chitin (CT) is widely used as a hemostatic material in surgical sponges, although its efficacy needs improvement to promote the clotting process.
35287883	0	21	theme	Chitin/corn	0:10	arg1	sponge					23:28	Chitin/corn stalk pith sponge	0:28	Chitin/corn stalk pith sponge	0:28	Chitin/corn stalk pith sponge stimulated hemostasis with erythrocyte absorption, platelet activation, and Ca2+-binding capabilities.
35287883	1	22	theme	clotting	261:268	arg1	process					270:276	the clotting process	257:276	the clotting process	257:276	Chitin (CT) is widely used as a hemostatic material in surgical sponges, although its efficacy needs improvement to promote the clotting process.
35287883	3	23	theme	In	532:533	arg1	analysis					552:559	In vitro hemostatic analysis	532:559	In vitro hemostatic analysis	532:559	In vitro hemostatic analysis indicated that CSP incorporation greatly promoted the coagulation process, with a much lower blood clot index and higher blood clot stability.
35287883	2	24	theme	ball	373:376	arg1	milling					378:384	ball milling	373:384	ball milling	373:384	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	0	25	theme	pith	18:21	arg1	sponge					23:28	Chitin/corn stalk pith sponge	0:28	Chitin/corn stalk pith sponge	0:28	Chitin/corn stalk pith sponge stimulated hemostasis with erythrocyte absorption, platelet activation, and Ca2+-binding capabilities.
35287883	3	26	theme	coagulation	615:625	arg1	process					627:633	the coagulation process	611:633	the coagulation process	611:633	In vitro hemostatic analysis indicated that CSP incorporation greatly promoted the coagulation process, with a much lower blood clot index and higher blood clot stability.
35287883	5	27	theme	complete	901:908	arg1	hemostasis					910:919	complete hemostasis	901:919	complete hemostasis	901:919	Consistently, it achieved complete hemostasis with less blood loss and a shorter hemostatic time in a rat liver injury-model.
35287883	1	28	theme	surgical	188:195	arg1	sponges					197:203	surgical sponges	188:203	surgical sponges	188:203	Chitin (CT) is widely used as a hemostatic material in surgical sponges, although its efficacy needs improvement to promote the clotting process.
35287883	5	29	theme	shorter	948:954	arg1	time					967:970	a shorter hemostatic time	946:970	a shorter hemostatic time in a rat liver injury-model	946:998	Consistently, it achieved complete hemostasis with less blood loss and a shorter hemostatic time in a rat liver injury-model.
35287883	2	30	theme	factor	504:509	arg1	accumulation					511:522	clotting factor accumulation	495:522	clotting factor accumulation (Ca2+)	495:529	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	2	30	theme	factor	504:509	arg1	Ca2+					525:528	Ca2+	525:528	Ca2+	525:528	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	5	31	theme	hemostatic	956:965	arg1	time					967:970	a shorter hemostatic time	946:970	a shorter hemostatic time in a rat liver injury-model	946:998	Consistently, it achieved complete hemostasis with less blood loss and a shorter hemostatic time in a rat liver injury-model.
35287883	5	32	from	time	967:970	arg1	injury-model					987:998	a rat liver injury-model	975:998	a rat liver injury-model	975:998	Consistently, it achieved complete hemostasis with less blood loss and a shorter hemostatic time in a rat liver injury-model.
35287883	2	33	theme	clotting	495:502	arg1	accumulation					511:522	clotting factor accumulation	495:522	clotting factor accumulation (Ca2+)	495:529	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	2	33	theme	clotting	495:502	arg1	Ca2+					525:528	Ca2+	525:528	Ca2+	525:528	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	2	34	theme	platelet	470:477	arg1	activation					479:488	platelet activation	470:488	platelet activation	470:488	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	0	35	theme	erythrocyte	57:67	arg1	absorption					69:78	erythrocyte absorption	57:78	erythrocyte absorption	57:78	Chitin/corn stalk pith sponge stimulated hemostasis with erythrocyte absorption, platelet activation, and Ca2+-binding capabilities.
35287883	4	36	theme	clotting	850:857	arg1	factors					859:865	clotting factors	850:865	clotting factors (Ca2+)	850:872	In addition, the composite sponge promoted more platelet adhesion and activation, and the composite sponge demonstrated a greater ability to bind clotting factors (Ca2+).
35287883	4	36	theme	clotting	850:857	arg1	Ca2+					868:871	Ca2+	868:871	Ca2+	868:871	In addition, the composite sponge promoted more platelet adhesion and activation, and the composite sponge demonstrated a greater ability to bind clotting factors (Ca2+).
35287883	3	37	theme	vitro	535:539	arg1	analysis					552:559	In vitro hemostatic analysis	532:559	In vitro hemostatic analysis	532:559	In vitro hemostatic analysis indicated that CSP incorporation greatly promoted the coagulation process, with a much lower blood clot index and higher blood clot stability.
35287883	2	38	theme	corn	317:320	arg1	pith					328:331	corn stalk pith	317:331	corn stalk pith (CSP)	317:337	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	2	38	theme	corn	317:320	arg1	biomass					308:314	another green biomass	294:314	another green biomass	294:314	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	2	38	theme	corn	317:320	arg1	CSP					334:336	CSP	334:336	CSP	334:336	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	2	39	theme	composite	406:414	arg1	sponges					427:433	CT-CSP composite hemostatic sponges	399:433	CT-CSP composite hemostatic sponges	399:433	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	5	40	theme	rat	977:979	arg1	injury-model					987:998	a rat liver injury-model	975:998	a rat liver injury-model	975:998	Consistently, it achieved complete hemostasis with less blood loss and a shorter hemostatic time in a rat liver injury-model.
35287883	3	41	theme	hemostatic	541:550	arg1	analysis					552:559	In vitro hemostatic analysis	532:559	In vitro hemostatic analysis	532:559	In vitro hemostatic analysis indicated that CSP incorporation greatly promoted the coagulation process, with a much lower blood clot index and higher blood clot stability.
35287883	4	42	theme	platelet	752:759	arg1	adhesion					761:768	more platelet adhesion	747:768	more platelet adhesion	747:768	In addition, the composite sponge promoted more platelet adhesion and activation, and the composite sponge demonstrated a greater ability to bind clotting factors (Ca2+).
35287883	5	43	theme	liver	981:985	arg1	injury-model					987:998	a rat liver injury-model	975:998	a rat liver injury-model	975:998	Consistently, it achieved complete hemostasis with less blood loss and a shorter hemostatic time in a rat liver injury-model.
35287883	5	44	theme	blood	931:935	arg1	loss					937:940	less blood loss	926:940	less blood loss	926:940	Consistently, it achieved complete hemostasis with less blood loss and a shorter hemostatic time in a rat liver injury-model.
35287883	6	45	theme	clinical	1142:1149	arg1	settings					1151:1158	clinical settings	1142:1158	clinical settings	1142:1158	This composite hemostatic sponge is sustainable, cost-efficient, and biocompatible, which highlight the excellent translational potential in clinical settings.
35287883	2	46	theme	green	302:306	arg1	pith					328:331	corn stalk pith	317:331	corn stalk pith (CSP)	317:337	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	2	46	theme	green	302:306	arg1	biomass					308:314	another green biomass	294:314	another green biomass	294:314	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	1	47	from	material	176:183	arg1	sponges					197:203	surgical sponges	188:203	surgical sponges	188:203	Chitin (CT) is widely used as a hemostatic material in surgical sponges, although its efficacy needs improvement to promote the clotting process.
35287883	2	48	theme	hemostatic	416:425	arg1	sponges					427:433	CT-CSP composite hemostatic sponges	399:433	CT-CSP composite hemostatic sponges	399:433	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
35287883	3	49	theme	clot	660:663	arg1	index					665:669	a much lower blood clot index	641:669	a much lower blood clot index	641:669	In vitro hemostatic analysis indicated that CSP incorporation greatly promoted the coagulation process, with a much lower blood clot index and higher blood clot stability.
35287883	3	50	theme	CSP	576:578	arg1	incorporation					580:592	CSP incorporation	576:592	CSP incorporation	576:592	In vitro hemostatic analysis indicated that CSP incorporation greatly promoted the coagulation process, with a much lower blood clot index and higher blood clot stability.
35287883	2	51	theme	CT-CSP	399:404	arg1	sponges					427:433	CT-CSP composite hemostatic sponges	399:433	CT-CSP composite hemostatic sponges	399:433	In this study, another green biomass, corn stalk pith (CSP), was incorporated into CT through ball milling to fabricate CT-CSP composite hemostatic sponges to enhance erythrocyte absorption, platelet activation, and clotting factor accumulation (Ca2+).
32385196	0	0	theme	dye	89:91	arg1	adsorption					93:102	textile dye adsorption	81:102	textile dye adsorption from wastewater	81:118	Synthesis, and characterization of chitosan bearing pyranoquinolinone moiety for textile dye adsorption from wastewater.
32385196	3	1	theme	red	484:486	arg1	dye					493:495	the textile anionic remazol red (RR) dye	456:495	the textile anionic remazol red (RR) dye from wastewater	456:511	Chitosan Schiff base was used to remove the textile anionic remazol red (RR) dye from wastewater.
32385196	1	2	theme	pyrano[3,2-c	230:241	arg1	moiety					270:275	pyrano[3,2-c]quinoline-3-carboxaldehyde moiety	230:275	pyrano[3,2-c]quinoline-3-carboxaldehyde moiety	230:275	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	0	3	theme	textile	81:87	arg1	adsorption					93:102	textile dye adsorption	81:102	textile dye adsorption from wastewater	81:118	Synthesis, and characterization of chitosan bearing pyranoquinolinone moiety for textile dye adsorption from wastewater.
32385196	1	4	theme	chitosan	331:338	arg1	base					325:328	a Schiff base	316:328	a Schiff base (chitosan Schiff base)	316:351	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	1	4	theme	chitosan	331:338	arg1	base					347:350	chitosan Schiff base	331:350	chitosan Schiff base	331:350	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	1	5	with	reaction	161:168	arg1	group					221:225	the formyl group	210:225	the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base)	210:351	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	1	5	with	reaction	161:168	arg1	moiety					270:275	pyrano[3,2-c]quinoline-3-carboxaldehyde moiety	230:275	pyrano[3,2-c]quinoline-3-carboxaldehyde moiety	230:275	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	3	6	from	wastewater	502:511	arg1	dye					493:495	the textile anionic remazol red (RR) dye	456:495	the textile anionic remazol red (RR) dye from wastewater	456:511	Chitosan Schiff base was used to remove the textile anionic remazol red (RR) dye from wastewater.
32385196	4	7	theme	adsorption	535:544	arg1	isotherm					546:553	adsorption isotherm	535:553	adsorption isotherm	535:553	The kinetic data and adsorption isotherm were best fitted by the pseudo-second-order kinetic model and the Freundlich isotherm, respectively.
32385196	1	8	theme	Schiff	340:345	arg1	base					325:328	a Schiff base	316:328	a Schiff base (chitosan Schiff base)	316:351	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	1	8	theme	Schiff	340:345	arg1	base					347:350	chitosan Schiff base	331:350	chitosan Schiff base	331:350	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	6	9	theme	qm	783:784	arg1	mg/g					792:795	qm 344.8 mg/g	783:795	qm 344.8 mg/g	783:795	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	1	10	theme	quinoline-3-carboxaldehyde	243:268	arg1	moiety					270:275	pyrano[3,2-c]quinoline-3-carboxaldehyde moiety	230:275	pyrano[3,2-c]quinoline-3-carboxaldehyde moiety	230:275	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	6	11	theme	Schiff	707:712	arg1	base					714:717	Chitosan Schiff base	698:717	Chitosan Schiff base	698:717	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	1	12	theme	moiety	270:275	arg1	group					221:225	the formyl group	210:225	the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base)	210:351	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	1	12	theme	moiety	270:275	arg1	moiety					270:275	pyrano[3,2-c]quinoline-3-carboxaldehyde moiety	230:275	pyrano[3,2-c]quinoline-3-carboxaldehyde moiety	230:275	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	6	13	theme	reactive	836:843	arg1	dyes					845:848	other anionic reactive dyes	822:848	other anionic reactive dyes	822:848	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	6	14	theme	Chitosan	698:705	arg1	base					714:717	Chitosan Schiff base	698:717	Chitosan Schiff base	698:717	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	3	15	theme	Schiff	425:430	arg1	base					432:435	Chitosan Schiff base	416:435	Chitosan Schiff base	416:435	Chitosan Schiff base was used to remove the textile anionic remazol red (RR) dye from wastewater.
32385196	6	16	theme	anionic	828:834	arg1	dyes					845:848	other anionic reactive dyes	822:848	other anionic reactive dyes	822:848	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	4	17	theme	Freundlich	621:630	arg1	isotherm					632:639	the Freundlich isotherm	617:639	the Freundlich isotherm	617:639	The kinetic data and adsorption isotherm were best fitted by the pseudo-second-order kinetic model and the Freundlich isotherm, respectively.
32385196	6	18	theme	other	822:826	arg1	dyes					845:848	other anionic reactive dyes	822:848	other anionic reactive dyes	822:848	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	3	19	used	used	441:444	arg2	base					432:435	Chitosan Schiff base	416:435	Chitosan Schiff base	416:435	Chitosan Schiff base was used to remove the textile anionic remazol red (RR) dye from wastewater.
32385196	1	20	theme	amino	177:181	arg1	group					183:187	the amino group	173:187	the amino group of the chitosan	173:203	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	1	20	theme	amino	177:181	arg1	chitosan					196:203	the chitosan	192:203	the chitosan	192:203	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	4	21	theme	kinetic	518:524	arg1	data					526:529	The kinetic data	514:529	The kinetic data	514:529	The kinetic data and adsorption isotherm were best fitted by the pseudo-second-order kinetic model and the Freundlich isotherm, respectively.
32385196	1	22	theme	group	183:187	arg1	reaction					161:168	the reaction	157:168	the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base)	157:351	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	6	23	theme	dye	760:762	arg1	removal					736:742	100% removal	731:742	100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g	731:795	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	4	24	theme	kinetic	599:605	arg1	model					607:611	the pseudo-second-order kinetic model	575:611	the pseudo-second-order kinetic model	575:611	The kinetic data and adsorption isotherm were best fitted by the pseudo-second-order kinetic model and the Freundlich isotherm, respectively.
32385196	0	25	theme	chitosan	35:42	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis, and characterization of chitosan bearing pyranoquinolinone moiety for textile dye adsorption from wastewater.
32385196	0	25	theme	chitosan	35:42	arg1	characterization					15:30	characterization	15:30	characterization	15:30	Synthesis, and characterization of chitosan bearing pyranoquinolinone moiety for textile dye adsorption from wastewater.
32385196	3	26	theme	remazol	476:482	arg1	dye					493:495	the textile anionic remazol red (RR) dye	456:495	the textile anionic remazol red (RR) dye from wastewater	456:511	Chitosan Schiff base was used to remove the textile anionic remazol red (RR) dye from wastewater.
32385196	1	27	theme	chitosan	196:203	arg1	group					183:187	the amino group	173:187	the amino group of the chitosan	173:203	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	1	27	theme	chitosan	196:203	arg1	chitosan					196:203	the chitosan	192:203	the chitosan	192:203	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	3	28	theme	Chitosan	416:423	arg1	base					432:435	Chitosan Schiff base	416:435	Chitosan Schiff base	416:435	Chitosan Schiff base was used to remove the textile anionic remazol red (RR) dye from wastewater.
32385196	2	29	theme	composite	390:398	arg1	structure					358:366	The structure	354:366	The structure of the newly prepared composite	354:398	The structure of the newly prepared composite was elucidated.
32385196	6	30	theme	carcinogenic	747:758	arg1	dye					760:762	carcinogenic dye	747:762	carcinogenic dye	747:762	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	2	31	theme	prepared	381:388	arg1	composite					390:398	the newly prepared composite	371:398	the newly prepared composite	371:398	The structure of the newly prepared composite was elucidated.
32385196	0	32	theme	pyranoquinolinone	52:68	arg1	moiety					70:75	pyranoquinolinone moiety	52:75	pyranoquinolinone moiety	52:75	Synthesis, and characterization of chitosan bearing pyranoquinolinone moiety for textile dye adsorption from wastewater.
32385196	3	33	theme	anionic	468:474	arg1	dye					493:495	the textile anionic remazol red (RR) dye	456:495	the textile anionic remazol red (RR) dye from wastewater	456:511	Chitosan Schiff base was used to remove the textile anionic remazol red (RR) dye from wastewater.
32385196	6	34	attach	removal	736:742	arg2	dye					760:762	carcinogenic dye	747:762	carcinogenic dye	747:762	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	6	34	attach	removal	736:742	arg3	min					769:771	2 min only	767:776	2 min only with qm 344.8 mg/g	767:795	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	5	35	theme	Thermodynamic	656:668	arg1	parameters					670:679	Thermodynamic parameters	656:679	Thermodynamic parameters	656:679	Thermodynamic parameters were calculated.
32385196	1	36	theme	novel	123:127	arg1	compound					129:136	A novel compound	121:136	A novel compound	121:136	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	1	37	theme	Schiff	318:323	arg1	base					325:328	a Schiff base	316:328	a Schiff base (chitosan Schiff base)	316:351	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	1	37	theme	Schiff	318:323	arg1	base					347:350	chitosan Schiff base	331:350	chitosan Schiff base	331:350	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	0	38	from	wastewater	109:118	arg1	adsorption					93:102	textile dye adsorption	81:102	textile dye adsorption from wastewater	81:118	Synthesis, and characterization of chitosan bearing pyranoquinolinone moiety for textile dye adsorption from wastewater.
32385196	6	39	theme	%	734:734	arg1	removal					736:742	100% removal	731:742	100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g	731:795	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	6	40	theme	100	731:733	arg1	%					734:734	%	734:734	%	734:734	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	3	41	theme	textile	460:466	arg1	dye					493:495	the textile anionic remazol red (RR) dye	456:495	the textile anionic remazol red (RR) dye from wastewater	456:511	Chitosan Schiff base was used to remove the textile anionic remazol red (RR) dye from wastewater.
32385196	1	42	theme	formyl	214:219	arg1	group					221:225	the formyl group	210:225	the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base)	210:351	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	1	42	theme	formyl	214:219	arg1	moiety					270:275	pyrano[3,2-c]quinoline-3-carboxaldehyde moiety	230:275	pyrano[3,2-c]quinoline-3-carboxaldehyde moiety	230:275	A novel compound was synthesized by the reaction of the amino group of the chitosan with the formyl group of pyrano[3,2-c]quinoline-3-carboxaldehyde moiety, which produced chitosan modified with a Schiff base (chitosan Schiff base).
32385196	3	43	theme	RR	489:490	arg1	dye					493:495	the textile anionic remazol red (RR) dye	456:495	the textile anionic remazol red (RR) dye from wastewater	456:511	Chitosan Schiff base was used to remove the textile anionic remazol red (RR) dye from wastewater.
32385196	4	44	theme	pseudo-second-order	579:597	arg1	model					607:611	the pseudo-second-order kinetic model	575:611	the pseudo-second-order kinetic model	575:611	The kinetic data and adsorption isotherm were best fitted by the pseudo-second-order kinetic model and the Freundlich isotherm, respectively.
32385196	6	45	with	min	769:771	arg1	mg/g					792:795	qm 344.8 mg/g	783:795	qm 344.8 mg/g	783:795	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	6	46	theme	secondary	865:873	arg1	pollution					875:883	secondary pollution	865:883	secondary pollution	865:883	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
32385196	6	47	from	min	769:771	arg1	removal					736:742	100% removal	731:742	100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g	731:795	Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
33547500	5	0	from	research	1040:1047	arg1	properties					1072:1081	the physicochemical properties	1052:1081	the physicochemical properties	1052:1081	This will also highlight how research on the physicochemical properties has helped alginate evolve from a structural polysaccharide in brown seaweed into a highly tuneable, multifunctional, smart biomaterial, which is likely to find further biomedical applications in the future.
33547500	4	1	theme	alginates	865:873	arg1	chemistry					852:860	the chemistry	848:860	the chemistry of alginates	848:873	The main focus is on how these strategies of understanding and controlling the chemistry of alginates have resulted in the development of hydrogels that can be tuned to deliver the physical behaviours required for successful application.
33547500	2	2	theme	tissue	456:461	arg1	engineering					463:473	tissue engineering	456:473	tissue engineering	456:473	In particular, the ease in which hydrogels are formed from alginate and the variety of mechanical behaviours that can be imparted on the hydrogels, by understanding alginate chemistry and intuitive design, has made alginate the most widely investigated polysaccharide used for tissue engineering.
33547500	5	3	theme	brown	1146:1150	arg1	seaweed					1152:1158	brown seaweed	1146:1158	brown seaweed	1146:1158	This will also highlight how research on the physicochemical properties has helped alginate evolve from a structural polysaccharide in brown seaweed into a highly tuneable, multifunctional, smart biomaterial, which is likely to find further biomedical applications in the future.
33547500	2	4	dep	made	389:392	arg1	alginate					394:401	alginate	394:401	alginate	394:401	In particular, the ease in which hydrogels are formed from alginate and the variety of mechanical behaviours that can be imparted on the hydrogels, by understanding alginate chemistry and intuitive design, has made alginate the most widely investigated polysaccharide used for tissue engineering.
33547500	5	5	dep	tuneable	1174:1181	arg1	multifunctional					1184:1198	multifunctional	1184:1198	multifunctional	1184:1198	This will also highlight how research on the physicochemical properties has helped alginate evolve from a structural polysaccharide in brown seaweed into a highly tuneable, multifunctional, smart biomaterial, which is likely to find further biomedical applications in the future.
33547500	5	5	dep	tuneable	1174:1181	arg1	smart					1201:1205	smart	1201:1205	smart	1201:1205	This will also highlight how research on the physicochemical properties has helped alginate evolve from a structural polysaccharide in brown seaweed into a highly tuneable, multifunctional, smart biomaterial, which is likely to find further biomedical applications in the future.
33547500	4	6	theme	main	777:780	arg1	focus					782:786	The main focus	773:786	The main focus	773:786	The main focus is on how these strategies of understanding and controlling the chemistry of alginates have resulted in the development of hydrogels that can be tuned to deliver the physical behaviours required for successful application.
33547500	4	6	theme	main	777:780	arg1	have					875:878	have	875:878	have resulted in the development of hydrogels that can be tuned to deliver the physical behaviours required for successful application	875:1008	The main focus is on how these strategies of understanding and controlling the chemistry of alginates have resulted in the development of hydrogels that can be tuned to deliver the physical behaviours required for successful application.
33547500	1	7	theme	favourable	147:156	arg1	properties					167:176	favourable physical properties	147:176	favourable physical properties	147:176	Alginate is a material that has many biomedical applications due to its low toxicity and a variety of favourable physical properties.
33547500	3	8	theme	alginate	513:520	arg1	overview					501:508	an overview	498:508	an overview of alginate	498:520	This chapter provides an overview of alginate, from how the source and natural variations in composition can influence mechanical properties of alginate hydrogels, through to some innovative techniques used to modify and functionalise the hydrogels designed specifically for cell-based therapies.
33547500	1	9	theme	physical	158:165	arg1	properties					167:176	favourable physical properties	147:176	favourable physical properties	147:176	Alginate is a material that has many biomedical applications due to its low toxicity and a variety of favourable physical properties.
33547500	5	10	theme	structural	1117:1126	arg1	polysaccharide					1128:1141	a structural polysaccharide	1115:1141	a structural polysaccharide in brown seaweed	1115:1158	This will also highlight how research on the physicochemical properties has helped alginate evolve from a structural polysaccharide in brown seaweed into a highly tuneable, multifunctional, smart biomaterial, which is likely to find further biomedical applications in the future.
33547500	1	11	theme	many	77:80	arg1	applications					93:104	many biomedical applications	77:104	many biomedical applications	77:104	Alginate is a material that has many biomedical applications due to its low toxicity and a variety of favourable physical properties.
33547500	1	12	theme	properties	167:176	arg1	properties					167:176	favourable physical properties	147:176	favourable physical properties	147:176	Alginate is a material that has many biomedical applications due to its low toxicity and a variety of favourable physical properties.
33547500	1	12	theme	properties	167:176	arg1	toxicity					121:128	its low toxicity	113:128	its low toxicity	113:128	Alginate is a material that has many biomedical applications due to its low toxicity and a variety of favourable physical properties.
33547500	1	12	theme	properties	167:176	arg1	variety					136:142	a variety	134:142	a variety of favourable physical properties	134:176	Alginate is a material that has many biomedical applications due to its low toxicity and a variety of favourable physical properties.
33547500	1	13	contain	has	73:75	arg2	applications					93:104	many biomedical applications	77:104	many biomedical applications	77:104	Alginate is a material that has many biomedical applications due to its low toxicity and a variety of favourable physical properties.
33547500	1	13	contain	has	73:75	arg1	Alginate					45:52	Alginate	45:52	Alginate	45:52	Alginate is a material that has many biomedical applications due to its low toxicity and a variety of favourable physical properties.
33547500	1	13	contain	has	73:75	arg1	material					59:66	a material	57:66	a material that has many biomedical applications due to its low toxicity and a variety of favourable physical properties	57:176	Alginate is a material that has many biomedical applications due to its low toxicity and a variety of favourable physical properties.
33547500	1	14	theme	biomedical	82:91	arg1	applications					93:104	many biomedical applications	77:104	many biomedical applications	77:104	Alginate is a material that has many biomedical applications due to its low toxicity and a variety of favourable physical properties.
33547500	2	15	theme	alginate	344:351	arg1	chemistry					353:361	alginate chemistry	344:361	alginate chemistry	344:361	In particular, the ease in which hydrogels are formed from alginate and the variety of mechanical behaviours that can be imparted on the hydrogels, by understanding alginate chemistry and intuitive design, has made alginate the most widely investigated polysaccharide used for tissue engineering.
33547500	0	16	theme	Tuneable	24:31	arg1	Properties					33:42	Tuneable Properties	24:42	Tuneable Properties	24:42	Alginate Hydrogels with Tuneable Properties.
33547500	3	17	theme	cell-based	751:760	arg1	therapies					762:770	cell-based therapies	751:770	cell-based therapies	751:770	This chapter provides an overview of alginate, from how the source and natural variations in composition can influence mechanical properties of alginate hydrogels, through to some innovative techniques used to modify and functionalise the hydrogels designed specifically for cell-based therapies.
33547500	2	18	theme	behaviours	277:286	arg1	variety					255:261	the variety	251:261	the variety of mechanical behaviours that can be imparted on the hydrogels	251:324	In particular, the ease in which hydrogels are formed from alginate and the variety of mechanical behaviours that can be imparted on the hydrogels, by understanding alginate chemistry and intuitive design, has made alginate the most widely investigated polysaccharide used for tissue engineering.
33547500	2	18	theme	behaviours	277:286	arg1	behaviours					277:286	mechanical behaviours	266:286	mechanical behaviours that can be imparted on the hydrogels	266:324	In particular, the ease in which hydrogels are formed from alginate and the variety of mechanical behaviours that can be imparted on the hydrogels, by understanding alginate chemistry and intuitive design, has made alginate the most widely investigated polysaccharide used for tissue engineering.
33547500	2	18	theme	behaviours	277:286	arg1	alginate					238:245	alginate	238:245	alginate	238:245	In particular, the ease in which hydrogels are formed from alginate and the variety of mechanical behaviours that can be imparted on the hydrogels, by understanding alginate chemistry and intuitive design, has made alginate the most widely investigated polysaccharide used for tissue engineering.
33547500	3	19	from	variations	555:564	arg1	composition					569:579	composition	569:579	composition	569:579	This chapter provides an overview of alginate, from how the source and natural variations in composition can influence mechanical properties of alginate hydrogels, through to some innovative techniques used to modify and functionalise the hydrogels designed specifically for cell-based therapies.
33547500	4	20	theme	hydrogels	911:919	arg1	development					896:906	the development	892:906	the development of hydrogels that can be tuned to deliver the physical behaviours required for successful application	892:1008	The main focus is on how these strategies of understanding and controlling the chemistry of alginates have resulted in the development of hydrogels that can be tuned to deliver the physical behaviours required for successful application.
33547500	3	21	theme	hydrogels	629:637	arg1	properties					606:615	mechanical properties	595:615	mechanical properties of alginate hydrogels	595:637	This chapter provides an overview of alginate, from how the source and natural variations in composition can influence mechanical properties of alginate hydrogels, through to some innovative techniques used to modify and functionalise the hydrogels designed specifically for cell-based therapies.
33547500	2	22	theme	mechanical	266:275	arg1	behaviours					277:286	mechanical behaviours	266:286	mechanical behaviours that can be imparted on the hydrogels	266:324	In particular, the ease in which hydrogels are formed from alginate and the variety of mechanical behaviours that can be imparted on the hydrogels, by understanding alginate chemistry and intuitive design, has made alginate the most widely investigated polysaccharide used for tissue engineering.
33547500	2	23	theme	intuitive	367:375	arg1	design					377:382	intuitive design	367:382	intuitive design	367:382	In particular, the ease in which hydrogels are formed from alginate and the variety of mechanical behaviours that can be imparted on the hydrogels, by understanding alginate chemistry and intuitive design, has made alginate the most widely investigated polysaccharide used for tissue engineering.
33547500	4	24	theme	successful	987:996	arg1	application					998:1008	successful application	987:1008	successful application	987:1008	The main focus is on how these strategies of understanding and controlling the chemistry of alginates have resulted in the development of hydrogels that can be tuned to deliver the physical behaviours required for successful application.
33547500	5	25	from	polysaccharide	1128:1141	arg1	seaweed					1152:1158	brown seaweed	1146:1158	brown seaweed	1146:1158	This will also highlight how research on the physicochemical properties has helped alginate evolve from a structural polysaccharide in brown seaweed into a highly tuneable, multifunctional, smart biomaterial, which is likely to find further biomedical applications in the future.
33547500	3	26	theme	alginate	620:627	arg1	hydrogels					629:637	alginate hydrogels	620:637	alginate hydrogels	620:637	This chapter provides an overview of alginate, from how the source and natural variations in composition can influence mechanical properties of alginate hydrogels, through to some innovative techniques used to modify and functionalise the hydrogels designed specifically for cell-based therapies.
33547500	3	27	theme	natural	547:553	arg1	variations					555:564	natural variations	547:564	natural variations in composition	547:579	This chapter provides an overview of alginate, from how the source and natural variations in composition can influence mechanical properties of alginate hydrogels, through to some innovative techniques used to modify and functionalise the hydrogels designed specifically for cell-based therapies.
33547500	2	28	theme	investigated	419:430	arg1	polysaccharide					432:445	the most widely investigated polysaccharide	403:445	the most widely investigated polysaccharide used for tissue engineering	403:473	In particular, the ease in which hydrogels are formed from alginate and the variety of mechanical behaviours that can be imparted on the hydrogels, by understanding alginate chemistry and intuitive design, has made alginate the most widely investigated polysaccharide used for tissue engineering.
33547500	5	29	theme	tuneable	1174:1181	arg1	biomaterial					1207:1217	a highly tuneable, multifunctional, smart biomaterial	1165:1217	a highly tuneable, multifunctional, smart biomaterial	1165:1217	This will also highlight how research on the physicochemical properties has helped alginate evolve from a structural polysaccharide in brown seaweed into a highly tuneable, multifunctional, smart biomaterial, which is likely to find further biomedical applications in the future.
33547500	5	29	theme	tuneable	1174:1181	arg1	likely					1229:1234	likely	1229:1234	likely	1229:1234	This will also highlight how research on the physicochemical properties has helped alginate evolve from a structural polysaccharide in brown seaweed into a highly tuneable, multifunctional, smart biomaterial, which is likely to find further biomedical applications in the future.
33547500	3	30	theme	innovative	656:665	arg1	techniques					667:676	some innovative techniques	651:676	some innovative techniques used to modify and functionalise the hydrogels designed specifically for cell-based therapies	651:770	This chapter provides an overview of alginate, from how the source and natural variations in composition can influence mechanical properties of alginate hydrogels, through to some innovative techniques used to modify and functionalise the hydrogels designed specifically for cell-based therapies.
33547500	3	31	theme	mechanical	595:604	arg1	properties					606:615	mechanical properties	595:615	mechanical properties of alginate hydrogels	595:637	This chapter provides an overview of alginate, from how the source and natural variations in composition can influence mechanical properties of alginate hydrogels, through to some innovative techniques used to modify and functionalise the hydrogels designed specifically for cell-based therapies.
33547500	1	32	theme	low	117:119	arg1	toxicity					121:128	its low toxicity	113:128	its low toxicity	113:128	Alginate is a material that has many biomedical applications due to its low toxicity and a variety of favourable physical properties.
33547500	3	33	from	source	536:541	arg1	composition					569:579	composition	569:579	composition	569:579	This chapter provides an overview of alginate, from how the source and natural variations in composition can influence mechanical properties of alginate hydrogels, through to some innovative techniques used to modify and functionalise the hydrogels designed specifically for cell-based therapies.
33547500	5	34	theme	physicochemical	1056:1070	arg1	properties					1072:1081	the physicochemical properties	1052:1081	the physicochemical properties	1052:1081	This will also highlight how research on the physicochemical properties has helped alginate evolve from a structural polysaccharide in brown seaweed into a highly tuneable, multifunctional, smart biomaterial, which is likely to find further biomedical applications in the future.
33547500	4	35	theme	physical	954:961	arg1	behaviours					963:972	the physical behaviours	950:972	the physical behaviours required for successful application	950:1008	The main focus is on how these strategies of understanding and controlling the chemistry of alginates have resulted in the development of hydrogels that can be tuned to deliver the physical behaviours required for successful application.
33547500	5	36	theme	biomedical	1252:1261	arg1	applications					1263:1274	further biomedical applications	1244:1274	further biomedical applications	1244:1274	This will also highlight how research on the physicochemical properties has helped alginate evolve from a structural polysaccharide in brown seaweed into a highly tuneable, multifunctional, smart biomaterial, which is likely to find further biomedical applications in the future.
33547500	5	37	theme	further	1244:1250	arg1	applications					1263:1274	further biomedical applications	1244:1274	further biomedical applications	1244:1274	This will also highlight how research on the physicochemical properties has helped alginate evolve from a structural polysaccharide in brown seaweed into a highly tuneable, multifunctional, smart biomaterial, which is likely to find further biomedical applications in the future.
33455783	7	0	theme	intestinal	1213:1222	arg1	infections					1234:1243	intestinal bacterial infections	1213:1243	intestinal bacterial infections	1213:1243	Functional predictions showed that FOS reduced intestinal bacterial infections and improved the endocrine and immune systems.
33455783	0	1	theme	mouse	171:175	arg1	intestine					154:162	the large intestine	144:162	the large intestine of the mouse	144:175	Effects of goat milk enriched with oligosaccharides on microbiota structures, and correlation between microbiota and short-chain fatty acids in the large intestine of the mouse.
33455783	2	2	theme	milk	327:330	arg1	combination					307:317	A combination	305:317	A combination of goat milk with each of 3 oligosaccharides-stachyose, fructo-oligosaccharide (FOS), and a prebiotics	305:420	A combination of goat milk with each of 3 oligosaccharides-stachyose, fructo-oligosaccharide (FOS), and a prebiotics mix-were independently fed to mice.
33455783	0	3	theme	large	148:152	arg1	intestine					154:162	the large intestine	144:162	the large intestine of the mouse	144:175	Effects of goat milk enriched with oligosaccharides on microbiota structures, and correlation between microbiota and short-chain fatty acids in the large intestine of the mouse.
33455783	1	4	theme	combining	220:228	arg1	milk					235:238	combining goat milk	220:238	combining goat milk	220:238	In this study, we explored the effects of combining goat milk and oligosaccharides on the large intestine environment of mice.
33455783	7	5	theme	bacterial	1224:1232	arg1	infections					1234:1243	intestinal bacterial infections	1213:1243	intestinal bacterial infections	1213:1243	Functional predictions showed that FOS reduced intestinal bacterial infections and improved the endocrine and immune systems.
33455783	3	6	theme	Spearman	667:674	arg1	correlation					676:686	a Spearman correlation	665:686	a Spearman correlation analysis between microorganisms and short-chain fatty acids	665:746	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	2	7	dep	mix-were	422:429	arg1	fed					445:447	fed	445:447	mix-were independently fed to mice	422:455	A combination of goat milk with each of 3 oligosaccharides-stachyose, fructo-oligosaccharide (FOS), and a prebiotics mix-were independently fed to mice.
33455783	4	8	from	diversity	783:791	arg1	intestine					806:814	the large intestine	796:814	the large intestine	796:814	Our results showed that microbial diversity in the large intestine decreased significantly in the FOS group.
33455783	2	9	theme	goat	322:325	arg1	milk					327:330	goat milk	322:330	goat milk	322:330	A combination of goat milk with each of 3 oligosaccharides-stachyose, fructo-oligosaccharide (FOS), and a prebiotics mix-were independently fed to mice.
33455783	1	10	theme	goat	230:233	arg1	milk					235:238	combining goat milk	220:238	combining goat milk	220:238	In this study, we explored the effects of combining goat milk and oligosaccharides on the large intestine environment of mice.
33455783	5	11	theme	microbial	992:1000	arg1	structures					1002:1011	the intestinal microbial structures	977:1011	the intestinal microbial structures	977:1011	In terms of α diversity, microbial richness significantly declined in all 3 treatment groups; in terms of β diversity, the intestinal microbial structures clearly changed in the FOS group.
33455783	3	12	theme	correlation	676:686	arg1	analysis					688:695	a Spearman correlation analysis	665:695	a Spearman correlation analysis between microorganisms and short-chain fatty acids	665:746	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	8	13	theme	valeric	1361:1367	arg1	acids					1369:1373	propionic, isobutyric, and valeric acids	1334:1373	propionic, isobutyric, and valeric acids	1334:1373	Spearman correlation analysis showed that propionic, isobutyric, and valeric acids were all positively correlated with certain microbiota.
33455783	1	14	theme	milk	235:238	arg1	effects					209:215	the effects	205:215	the effects of combining goat milk and oligosaccharides on the large intestine environment of mice	205:302	In this study, we explored the effects of combining goat milk and oligosaccharides on the large intestine environment of mice.
33455783	5	15	theme	treatment	934:942	arg1	groups					944:949	all 3 treatment groups	928:949	all 3 treatment groups	928:949	In terms of α diversity, microbial richness significantly declined in all 3 treatment groups; in terms of β diversity, the intestinal microbial structures clearly changed in the FOS group.
33455783	3	16	theme	short-chain	724:734	arg1	acids					742:746	short-chain fatty acids	724:746	short-chain fatty acids	724:746	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	3	17	theme	large	519:523	arg1	intestine					525:533	the large intestine	515:533	the large intestine	515:533	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	3	18	theme	composition	474:484	arg1	changes					486:492	composition changes	474:492	composition changes	474:492	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	9	19	theme	FOS-enriched	1457:1468	arg1	milk					1475:1478	FOS-enriched goat milk	1457:1478	FOS-enriched goat milk	1457:1478	Our findings suggest that FOS-enriched goat milk is beneficial for improving the large intestine environment in the host.
33455783	0	20	from	oligosaccharides	35:50	arg1	structures					66:75	microbiota structures	55:75	microbiota structures	55:75	Effects of goat milk enriched with oligosaccharides on microbiota structures, and correlation between microbiota and short-chain fatty acids in the large intestine of the mouse.
33455783	0	20	from	oligosaccharides	35:50	arg1	correlation					82:92	correlation	82:92	correlation between microbiota and short-chain fatty acids in the large intestine of the mouse	82:175	Effects of goat milk enriched with oligosaccharides on microbiota structures, and correlation between microbiota and short-chain fatty acids in the large intestine of the mouse.
33455783	6	21	theme	Lactobacillus	1084:1096	arg1	abundance					1051:1059	The abundance	1047:1059	The abundance of Bifidobacterium and Lactobacillus	1047:1096	The abundance of Bifidobacterium and Lactobacillus increased markedly in the FOS group compared with the other groups.
33455783	5	22	theme	β	964:964	arg1	diversity					966:974	β diversity	964:974	β diversity	964:974	In terms of α diversity, microbial richness significantly declined in all 3 treatment groups; in terms of β diversity, the intestinal microbial structures clearly changed in the FOS group.
33455783	6	23	theme	Bifidobacterium	1064:1078	arg1	abundance					1051:1059	The abundance	1047:1059	The abundance of Bifidobacterium and Lactobacillus	1047:1096	The abundance of Bifidobacterium and Lactobacillus increased markedly in the FOS group compared with the other groups.
33455783	4	24	theme	FOS	847:849	arg1	group					851:855	the FOS group	843:855	the FOS group	843:855	Our results showed that microbial diversity in the large intestine decreased significantly in the FOS group.
33455783	4	25	theme	microbial	773:781	arg1	diversity					783:791	microbial diversity	773:791	microbial diversity in the large intestine	773:814	Our results showed that microbial diversity in the large intestine decreased significantly in the FOS group.
33455783	7	26	theme	Functional	1166:1175	arg1	predictions					1177:1187	Functional predictions	1166:1187	Functional predictions	1166:1187	Functional predictions showed that FOS reduced intestinal bacterial infections and improved the endocrine and immune systems.
33455783	6	27	theme	other	1152:1156	arg1	groups					1158:1163	the other groups	1148:1163	the other groups	1148:1163	The abundance of Bifidobacterium and Lactobacillus increased markedly in the FOS group compared with the other groups.
33455783	3	28	theme	16S	541:543	arg1	sequencing					555:564	16S rRNA gene sequencing	541:564	16S rRNA gene sequencing	541:564	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	3	29	theme	fatty	736:740	arg1	acids					742:746	short-chain fatty acids	724:746	short-chain fatty acids	724:746	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	5	30	theme	α	870:870	arg1	diversity					872:880	α diversity	870:880	α diversity	870:880	In terms of α diversity, microbial richness significantly declined in all 3 treatment groups; in terms of β diversity, the intestinal microbial structures clearly changed in the FOS group.
33455783	1	31	theme	oligosaccharides	244:259	arg1	effects					209:215	the effects	205:215	the effects of combining goat milk and oligosaccharides on the large intestine environment of mice	205:302	In this study, we explored the effects of combining goat milk and oligosaccharides on the large intestine environment of mice.
33455783	3	32	theme	rRNA	545:548	arg1	sequencing					555:564	16S rRNA gene sequencing	541:564	16S rRNA gene sequencing	541:564	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	5	33	theme	diversity	872:880	arg1	terms					861:865	terms	861:865	terms of α diversity	861:880	In terms of α diversity, microbial richness significantly declined in all 3 treatment groups; in terms of β diversity, the intestinal microbial structures clearly changed in the FOS group.
33455783	0	34	theme	milk	16:19	arg1	Effects					0:6	Effects	0:6	Effects of goat milk	0:19	Effects of goat milk enriched with oligosaccharides on microbiota structures, and correlation between microbiota and short-chain fatty acids in the large intestine of the mouse.
33455783	5	35	theme	intestinal	981:990	arg1	structures					1002:1011	the intestinal microbial structures	977:1011	the intestinal microbial structures	977:1011	In terms of α diversity, microbial richness significantly declined in all 3 treatment groups; in terms of β diversity, the intestinal microbial structures clearly changed in the FOS group.
33455783	0	36	theme	fatty	129:133	arg1	acids					135:139	short-chain fatty acids	117:139	short-chain fatty acids	117:139	Effects of goat milk enriched with oligosaccharides on microbiota structures, and correlation between microbiota and short-chain fatty acids in the large intestine of the mouse.
33455783	3	37	theme	intestine	525:533	arg1	microbiota					501:510	the microbiota	497:510	the microbiota of the large intestine	497:533	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	0	38	theme	goat	11:14	arg1	milk					16:19	goat milk	11:19	goat milk	11:19	Effects of goat milk enriched with oligosaccharides on microbiota structures, and correlation between microbiota and short-chain fatty acids in the large intestine of the mouse.
33455783	0	39	theme	short-chain	117:127	arg1	acids					135:139	short-chain fatty acids	117:139	short-chain fatty acids	117:139	Effects of goat milk enriched with oligosaccharides on microbiota structures, and correlation between microbiota and short-chain fatty acids in the large intestine of the mouse.
33455783	3	40	theme	chromatography-mass	617:635	arg1	spectrometry					637:648	gas chromatography-mass spectrometry	613:648	gas chromatography-mass spectrometry	613:648	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	8	41	theme	isobutyric	1345:1354	arg1	acids					1369:1373	propionic, isobutyric, and valeric acids	1334:1373	propionic, isobutyric, and valeric acids	1334:1373	Spearman correlation analysis showed that propionic, isobutyric, and valeric acids were all positively correlated with certain microbiota.
33455783	1	42	theme	large	268:272	arg1	intestine					274:282	the large intestine	264:282	the large intestine environment of mice	264:302	In this study, we explored the effects of combining goat milk and oligosaccharides on the large intestine environment of mice.
33455783	4	43	theme	large	800:804	arg1	intestine					806:814	the large intestine	796:814	the large intestine	796:814	Our results showed that microbial diversity in the large intestine decreased significantly in the FOS group.
33455783	8	44	theme	Spearman	1292:1299	arg1	analysis					1313:1320	Spearman correlation analysis	1292:1320	Spearman correlation analysis	1292:1320	Spearman correlation analysis showed that propionic, isobutyric, and valeric acids were all positively correlated with certain microbiota.
33455783	9	45	theme	goat	1470:1473	arg1	milk					1475:1478	FOS-enriched goat milk	1457:1478	FOS-enriched goat milk	1457:1478	Our findings suggest that FOS-enriched goat milk is beneficial for improving the large intestine environment in the host.
33455783	1	46	theme	intestine	274:282	arg1	environment					284:294	the large intestine environment	264:294	the large intestine environment of mice	264:302	In this study, we explored the effects of combining goat milk and oligosaccharides on the large intestine environment of mice.
33455783	0	47	from	structures	66:75	arg1	intestine					154:162	the large intestine	144:162	the large intestine of the mouse	144:175	Effects of goat milk enriched with oligosaccharides on microbiota structures, and correlation between microbiota and short-chain fatty acids in the large intestine of the mouse.
33455783	8	48	theme	certain	1411:1417	arg1	microbiota					1419:1428	certain microbiota	1411:1428	certain microbiota	1411:1428	Spearman correlation analysis showed that propionic, isobutyric, and valeric acids were all positively correlated with certain microbiota.
33455783	9	49	theme	large	1512:1516	arg1	intestine					1518:1526	the large intestine	1508:1526	the large intestine environment	1508:1538	Our findings suggest that FOS-enriched goat milk is beneficial for improving the large intestine environment in the host.
33455783	1	50	from	effects	209:215	arg1	environment					284:294	the large intestine environment	264:294	the large intestine environment of mice	264:302	In this study, we explored the effects of combining goat milk and oligosaccharides on the large intestine environment of mice.
33455783	2	51	with	combination	307:317	arg1	oligosaccharides-stachyose					347:372	3 oligosaccharides-stachyose	345:372	3 oligosaccharides-stachyose	345:372	A combination of goat milk with each of 3 oligosaccharides-stachyose, fructo-oligosaccharide (FOS), and a prebiotics mix-were independently fed to mice.
33455783	2	51	with	combination	307:317	arg1	prebiotics					411:420	a prebiotics	409:420	a prebiotics	409:420	A combination of goat milk with each of 3 oligosaccharides-stachyose, fructo-oligosaccharide (FOS), and a prebiotics mix-were independently fed to mice.
33455783	2	51	with	combination	307:317	arg1	FOS					399:401	FOS	399:401	FOS	399:401	A combination of goat milk with each of 3 oligosaccharides-stachyose, fructo-oligosaccharide (FOS), and a prebiotics mix-were independently fed to mice.
33455783	2	51	with	combination	307:317	arg1	fructo-oligosaccharide					375:396	fructo-oligosaccharide	375:396	fructo-oligosaccharide (FOS)	375:402	A combination of goat milk with each of 3 oligosaccharides-stachyose, fructo-oligosaccharide (FOS), and a prebiotics mix-were independently fed to mice.
33455783	2	51	with	combination	307:317	arg1	each					337:340	each	337:340	each	337:340	A combination of goat milk with each of 3 oligosaccharides-stachyose, fructo-oligosaccharide (FOS), and a prebiotics mix-were independently fed to mice.
33455783	3	52	theme	gene	550:553	arg1	sequencing					555:564	16S rRNA gene sequencing	541:564	16S rRNA gene sequencing	541:564	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	9	53	theme	intestine	1518:1526	arg1	environment					1528:1538	the large intestine environment	1508:1538	the large intestine environment	1508:1538	Our findings suggest that FOS-enriched goat milk is beneficial for improving the large intestine environment in the host.
33455783	3	54	theme	gas	613:615	arg1	spectrometry					637:648	gas chromatography-mass spectrometry	613:648	gas chromatography-mass spectrometry	613:648	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	6	55	theme	FOS	1124:1126	arg1	group					1128:1132	the FOS group	1120:1132	the FOS group	1120:1132	The abundance of Bifidobacterium and Lactobacillus increased markedly in the FOS group compared with the other groups.
33455783	1	56	theme	mice	299:302	arg1	environment					284:294	the large intestine environment	264:294	the large intestine environment of mice	264:302	In this study, we explored the effects of combining goat milk and oligosaccharides on the large intestine environment of mice.
33455783	5	57	theme	FOS	1036:1038	arg1	group					1040:1044	the FOS group	1032:1044	the FOS group	1032:1044	In terms of α diversity, microbial richness significantly declined in all 3 treatment groups; in terms of β diversity, the intestinal microbial structures clearly changed in the FOS group.
33455783	3	58	theme	acid	594:597	arg1	content					599:605	short-chain fatty acid content	576:605	short-chain fatty acid content	576:605	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	7	59	theme	immune	1276:1281	arg1	systems					1283:1289	the endocrine and immune systems	1258:1289	the endocrine and immune systems	1258:1289	Functional predictions showed that FOS reduced intestinal bacterial infections and improved the endocrine and immune systems.
33455783	5	60	theme	diversity	966:974	arg1	terms					955:959	terms	955:959	terms of β diversity	955:974	In terms of α diversity, microbial richness significantly declined in all 3 treatment groups; in terms of β diversity, the intestinal microbial structures clearly changed in the FOS group.
33455783	8	61	theme	propionic	1334:1342	arg1	acids					1369:1373	propionic, isobutyric, and valeric acids	1334:1373	propionic, isobutyric, and valeric acids	1334:1373	Spearman correlation analysis showed that propionic, isobutyric, and valeric acids were all positively correlated with certain microbiota.
33455783	0	62	from	correlation	82:92	arg1	intestine					154:162	the large intestine	144:162	the large intestine of the mouse	144:175	Effects of goat milk enriched with oligosaccharides on microbiota structures, and correlation between microbiota and short-chain fatty acids in the large intestine of the mouse.
33455783	3	63	theme	short-chain	576:586	arg1	acid					594:597	short-chain fatty acid	576:597	short-chain fatty acid content	576:605	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	7	64	theme	endocrine	1262:1270	arg1	systems					1283:1289	the endocrine and immune systems	1258:1289	the endocrine and immune systems	1258:1289	Functional predictions showed that FOS reduced intestinal bacterial infections and improved the endocrine and immune systems.
33455783	0	65	theme	microbiota	55:64	arg1	structures					66:75	microbiota structures	55:75	microbiota structures	55:75	Effects of goat milk enriched with oligosaccharides on microbiota structures, and correlation between microbiota and short-chain fatty acids in the large intestine of the mouse.
33455783	3	66	theme	fatty	588:592	arg1	acid					594:597	short-chain fatty acid	576:597	short-chain fatty acid content	576:605	We investigated composition changes in the microbiota of the large intestine using 16S rRNA gene sequencing; measured short-chain fatty acid content using gas chromatography-mass spectrometry; and performed a Spearman correlation analysis between microorganisms and short-chain fatty acids.
33455783	5	67	theme	microbial	883:891	arg1	richness					893:900	microbial richness	883:900	microbial richness	883:900	In terms of α diversity, microbial richness significantly declined in all 3 treatment groups; in terms of β diversity, the intestinal microbial structures clearly changed in the FOS group.
33455783	8	68	theme	correlation	1301:1311	arg1	analysis					1313:1320	Spearman correlation analysis	1292:1320	Spearman correlation analysis	1292:1320	Spearman correlation analysis showed that propionic, isobutyric, and valeric acids were all positively correlated with certain microbiota.
33807800	0	0	theme	Beet	83:86	arg1	Pulp					88:91	Sugar Beet Pulp	77:91	Sugar Beet Pulp Using Subcritical Water Extraction Process	77:134	Physicochemical, Thermal and Rheological Properties of Pectin Extracted from Sugar Beet Pulp Using Subcritical Water Extraction Process.
33807800	5	1	theme	SWE	692:694	arg1	ratio					734:738	liquid-to-solid (L/S) ratio	712:738	liquid-to-solid (L/S) ratio of 30% (v/w)	712:751	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	5	1	theme	SWE	692:694	arg1	conditions					696:705	The optimal SWE conditions	680:705	The optimal SWE conditions	680:705	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	10	2	theme	lower	1280:1284	arg1	concentrations					1286:1299	lower concentrations	1280:1299	lower concentrations	1280:1299	Solutions of pectins at lower concentrations displayed nearly Newtonian behavior.
33807800	5	3	theme	%	745:745	arg1	ratio					734:738	liquid-to-solid (L/S) ratio	712:738	liquid-to-solid (L/S) ratio of 30% (v/w)	712:751	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	5	3	theme	%	745:745	arg1	conditions					696:705	The optimal SWE conditions	680:705	The optimal SWE conditions	680:705	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	10	4	from	Solutions	1256:1264	arg1	concentrations					1286:1299	lower concentrations	1280:1299	lower concentrations	1280:1299	Solutions of pectins at lower concentrations displayed nearly Newtonian behavior.
33807800	6	5	theme	pectins	860:866	arg1	effect					841:846	The effect	837:846	The effect of obtained pectins on viscoamylograph pasting and DSC thermal parameters of corn starch	837:935	The effect of obtained pectins on viscoamylograph pasting and DSC thermal parameters of corn starch was evaluated.
33807800	0	6	theme	Sugar	77:81	arg1	Pulp					88:91	Sugar Beet Pulp	77:91	Sugar Beet Pulp Using Subcritical Water Extraction Process	77:134	Physicochemical, Thermal and Rheological Properties of Pectin Extracted from Sugar Beet Pulp Using Subcritical Water Extraction Process.
33807800	1	7	dep	SWE	266:268	arg1	compared					274:281	compared	274:281	compared to conventional extraction (CE)	274:313	The objective of this study was to characterize the properties of pectin extracted from sugar beet pulp using subcritical water (SWE) as compared to conventional extraction (CE).
33807800	1	8	theme	study	159:163	arg1	objective					141:149	The objective	137:149	The objective of this study	137:163	The objective of this study was to characterize the properties of pectin extracted from sugar beet pulp using subcritical water (SWE) as compared to conventional extraction (CE).
33807800	1	9	theme	subcritical	247:257	arg1	SWE					266:268	subcritical water (SWE)	247:269	subcritical water (SWE) as compared to conventional extraction (CE)	247:313	The objective of this study was to characterize the properties of pectin extracted from sugar beet pulp using subcritical water (SWE) as compared to conventional extraction (CE).
33807800	10	10	from	concentrations	1286:1299	arg1	pectins					1269:1275	pectins	1269:1275	pectins at lower concentrations	1269:1299	Solutions of pectins at lower concentrations displayed nearly Newtonian behavior.
33807800	10	10	from	concentrations	1286:1299	arg1	Solutions					1256:1264	Solutions	1256:1264	Solutions of pectins at lower concentrations	1256:1299	Solutions of pectins at lower concentrations displayed nearly Newtonian behavior.
33807800	7	11	theme	galacturonic	968:979	arg1	acid					981:984	galacturonic acid	968:984	galacturonic acid	968:984	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
33807800	7	11	theme	galacturonic	968:979	arg1	degree					987:992	degree	987:992	degree of methylation, acetylation, and ferulic acid content	987:1046	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
33807800	12	12	theme	improved	1579:1586	arg1	properties					1595:1604	improved pectin properties	1579:1604	improved pectin properties	1579:1604	The results offered a promising scalable approach to convert the beet waste to pectin as a value-added product using SWE with improved pectin properties.
33807800	4	13	theme	%	677:677	arg1	pH					635:636	pH	635:636	pH of 1	635:641	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	13	theme	%	677:677	arg1	time					618:621	time	618:621	time of 240 min	618:632	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	13	theme	%	677:677	arg1	temperature					596:606	the temperature	592:606	the temperature of 90 °C	592:615	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	13	theme	%	677:677	arg1	conditions					570:579	The optimum conditions	558:579	The optimum conditions of CE	558:585	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	13	theme	%	677:677	arg1	yield					664:668	pectin recovery yield	648:668	pectin recovery yield of 20.8%	648:677	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	1	14	theme	water	259:263	arg1	SWE					266:268	subcritical water (SWE)	247:269	subcritical water (SWE) as compared to conventional extraction (CE)	247:313	The objective of this study was to characterize the properties of pectin extracted from sugar beet pulp using subcritical water (SWE) as compared to conventional extraction (CE).
33807800	11	15	theme	gelatinization	1408:1421	arg1	parameters					1423:1432	DSC gelatinization parameters	1404:1432	DSC gelatinization parameters	1404:1432	The addition of both pectins to corn starch decreased pasting and DSC gelatinization parameters, but increased ΔH.
33807800	5	16	theme	%	834:834	arg1	yield					821:825	a comparable yield	808:825	a comparable yield of 20.7%	808:834	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	11	17	theme	corn	1370:1373	arg1	starch					1375:1380	corn starch	1370:1380	corn starch	1370:1380	The addition of both pectins to corn starch decreased pasting and DSC gelatinization parameters, but increased ΔH.
33807800	3	18	theme	central	532:538	arg1	design					550:555	the central composite design	528:555	the central composite design	528:555	The optimal conditions for maximum yield of pectin for SWE and CE methods were determined by the central composite design.
33807800	4	19	theme	recovery	655:662	arg1	yield					664:668	pectin recovery yield	648:668	pectin recovery yield of 20.8%	648:677	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	0	20	theme	Water	111:115	arg1	Process					128:134	Subcritical Water Extraction Process	99:134	Subcritical Water Extraction Process	99:134	Physicochemical, Thermal and Rheological Properties of Pectin Extracted from Sugar Beet Pulp Using Subcritical Water Extraction Process.
33807800	8	21	theme	Similar	1130:1136	arg1	groups					1147:1152	Similar chemical groups	1130:1152	Similar chemical groups	1130:1152	Similar chemical groups were characterized by FTIR in both SWE and CE pectins.
33807800	10	22	theme	Newtonian	1318:1326	arg1	behavior					1328:1335	Newtonian behavior	1318:1335	Newtonian behavior	1318:1335	Solutions of pectins at lower concentrations displayed nearly Newtonian behavior.
33807800	6	23	theme	starch	930:935	arg1	parameters					911:920	viscoamylograph pasting and DSC thermal parameters	871:920	viscoamylograph pasting and DSC thermal parameters of corn starch	871:935	The effect of obtained pectins on viscoamylograph pasting and DSC thermal parameters of corn starch was evaluated.
33807800	5	24	theme	liquid-to-solid	712:726	arg1	ratio					734:738	liquid-to-solid (L/S) ratio	712:738	liquid-to-solid (L/S) ratio of 30% (v/w)	712:751	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	5	24	theme	liquid-to-solid	712:726	arg1	conditions					696:705	The optimal SWE conditions	680:705	The optimal SWE conditions	680:705	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	0	25	theme	Subcritical	99:109	arg1	Process					128:134	Subcritical Water Extraction Process	99:134	Subcritical Water Extraction Process	99:134	Physicochemical, Thermal and Rheological Properties of Pectin Extracted from Sugar Beet Pulp Using Subcritical Water Extraction Process.
33807800	6	26	from	effect	841:846	arg1	parameters					911:920	viscoamylograph pasting and DSC thermal parameters	871:920	viscoamylograph pasting and DSC thermal parameters of corn starch	871:935	The effect of obtained pectins on viscoamylograph pasting and DSC thermal parameters of corn starch was evaluated.
33807800	4	27	theme	°C	614:615	arg1	pH					635:636	pH	635:636	pH of 1	635:641	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	27	theme	°C	614:615	arg1	time					618:621	time	618:621	time of 240 min	618:632	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	27	theme	°C	614:615	arg1	temperature					596:606	the temperature	592:606	the temperature of 90 °C	592:615	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	27	theme	°C	614:615	arg1	conditions					570:579	The optimum conditions	558:579	The optimum conditions of CE	558:585	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	27	theme	°C	614:615	arg1	yield					664:668	pectin recovery yield	648:668	pectin recovery yield of 20.8%	648:677	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	3	28	dep	SWE	490:492	arg1	methods					501:507	methods	501:507	methods	501:507	The optimal conditions for maximum yield of pectin for SWE and CE methods were determined by the central composite design.
33807800	12	29	theme	beet	1518:1521	arg1	waste					1523:1527	the beet waste	1514:1527	the beet waste to pectin	1514:1537	The results offered a promising scalable approach to convert the beet waste to pectin as a value-added product using SWE with improved pectin properties.
33807800	12	29	theme	beet	1518:1521	arg1	product					1556:1562	a value-added product	1542:1562	a value-added product using SWE with improved pectin properties	1542:1604	The results offered a promising scalable approach to convert the beet waste to pectin as a value-added product using SWE with improved pectin properties.
33807800	2	30	theme	surface	371:377	arg1	methodology					379:389	response surface methodology	362:389	response surface methodology	362:389	The research involved advanced modeling using response surface methodology and optimization of operational parameters.
33807800	7	31	theme	ferulic	1027:1033	arg1	content					1040:1046	ferulic acid content	1027:1046	ferulic acid content	1027:1046	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
33807800	2	32	theme	response	362:369	arg1	methodology					379:389	response surface methodology	362:389	response surface methodology	362:389	The research involved advanced modeling using response surface methodology and optimization of operational parameters.
33807800	0	33	theme	Physicochemical	0:14	arg1	Properties					41:50	Physicochemical, Thermal and Rheological Properties	0:50	Physicochemical, Thermal and Rheological Properties of Pectin	0:60	Physicochemical, Thermal and Rheological Properties of Pectin Extracted from Sugar Beet Pulp Using Subcritical Water Extraction Process.
33807800	7	34	theme	acetylation	1010:1020	arg1	acid					981:984	galacturonic acid	968:984	galacturonic acid	968:984	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
33807800	7	34	theme	acetylation	1010:1020	arg1	degree					987:992	degree	987:992	degree of methylation, acetylation, and ferulic acid content	987:1046	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
33807800	12	35	theme	pectin	1588:1593	arg1	properties					1595:1604	improved pectin properties	1579:1604	improved pectin properties	1579:1604	The results offered a promising scalable approach to convert the beet waste to pectin as a value-added product using SWE with improved pectin properties.
33807800	5	36	theme	comparable	810:819	arg1	yield					821:825	a comparable yield	808:825	a comparable yield of 20.7%	808:834	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	12	37	theme	promising	1475:1483	arg1	approach					1494:1501	a promising scalable approach	1473:1501	a promising scalable approach to convert the beet waste to pectin as a value-added product using SWE with improved pectin properties	1473:1604	The results offered a promising scalable approach to convert the beet waste to pectin as a value-added product using SWE with improved pectin properties.
33807800	4	38	theme	min	630:632	arg1	pH					635:636	pH	635:636	pH of 1	635:641	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	38	theme	min	630:632	arg1	time					618:621	time	618:621	time of 240 min	618:632	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	38	theme	min	630:632	arg1	temperature					596:606	the temperature	592:606	the temperature of 90 °C	592:615	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	38	theme	min	630:632	arg1	conditions					570:579	The optimum conditions	558:579	The optimum conditions of CE	558:585	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	38	theme	min	630:632	arg1	yield					664:668	pectin recovery yield	648:668	pectin recovery yield of 20.8%	648:677	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	11	39	theme	DSC	1404:1406	arg1	parameters					1423:1432	DSC gelatinization parameters	1404:1432	DSC gelatinization parameters	1404:1432	The addition of both pectins to corn starch decreased pasting and DSC gelatinization parameters, but increased ΔH.
33807800	3	40	theme	composite	540:548	arg1	design					550:555	the central composite design	528:555	the central composite design	528:555	The optimal conditions for maximum yield of pectin for SWE and CE methods were determined by the central composite design.
33807800	2	41	theme	operational	411:421	arg1	parameters					423:432	operational parameters	411:432	operational parameters	411:432	The research involved advanced modeling using response surface methodology and optimization of operational parameters.
33807800	2	42	theme	parameters	423:432	arg1	optimization					395:406	optimization	395:406	optimization of operational parameters	395:432	The research involved advanced modeling using response surface methodology and optimization of operational parameters.
33807800	2	42	theme	parameters	423:432	arg1	methodology					379:389	response surface methodology	362:389	response surface methodology	362:389	The research involved advanced modeling using response surface methodology and optimization of operational parameters.
33807800	0	43	theme	Extraction	117:126	arg1	Process					128:134	Subcritical Water Extraction Process	99:134	Subcritical Water Extraction Process	99:134	Physicochemical, Thermal and Rheological Properties of Pectin Extracted from Sugar Beet Pulp Using Subcritical Water Extraction Process.
33807800	4	44	theme	1	641:641	arg1	pH					635:636	pH	635:636	pH of 1	635:641	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	44	theme	1	641:641	arg1	time					618:621	time	618:621	time of 240 min	618:632	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	44	theme	1	641:641	arg1	temperature					596:606	the temperature	592:606	the temperature of 90 °C	592:615	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	44	theme	1	641:641	arg1	conditions					570:579	The optimum conditions	558:579	The optimum conditions of CE	558:585	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	44	theme	1	641:641	arg1	yield					664:668	pectin recovery yield	648:668	pectin recovery yield of 20.8%	648:677	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	6	45	theme	thermal	903:909	arg1	parameters					911:920	viscoamylograph pasting and DSC thermal parameters	871:920	viscoamylograph pasting and DSC thermal parameters of corn starch	871:935	The effect of obtained pectins on viscoamylograph pasting and DSC thermal parameters of corn starch was evaluated.
33807800	9	46	theme	pectins	1234:1240	arg1	attributes					1215:1224	Color attributes	1209:1224	Color attributes of both pectins	1209:1240	Color attributes of both pectins were similar.
33807800	6	47	theme	corn	925:928	arg1	starch					930:935	corn starch	925:935	corn starch	925:935	The effect of obtained pectins on viscoamylograph pasting and DSC thermal parameters of corn starch was evaluated.
33807800	1	48	theme	pectin	203:208	arg1	properties					189:198	the properties	185:198	the properties of pectin extracted from sugar beet pulp using subcritical water (SWE) as compared to conventional extraction (CE)	185:313	The objective of this study was to characterize the properties of pectin extracted from sugar beet pulp using subcritical water (SWE) as compared to conventional extraction (CE).
33807800	0	49	theme	Rheological	29:39	arg1	Properties					41:50	Physicochemical, Thermal and Rheological Properties	0:50	Physicochemical, Thermal and Rheological Properties of Pectin	0:60	Physicochemical, Thermal and Rheological Properties of Pectin Extracted from Sugar Beet Pulp Using Subcritical Water Extraction Process.
33807800	4	50	theme	optimum	562:568	arg1	temperature					596:606	the temperature	592:606	the temperature of 90 °C	592:615	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	50	theme	optimum	562:568	arg1	conditions					570:579	The optimum conditions	558:579	The optimum conditions of CE	558:585	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	6	51	theme	obtained	851:858	arg1	pectins					860:866	obtained pectins	851:866	obtained pectins	851:866	The effect of obtained pectins on viscoamylograph pasting and DSC thermal parameters of corn starch was evaluated.
33807800	8	52	theme	chemical	1138:1145	arg1	groups					1147:1152	Similar chemical groups	1130:1152	Similar chemical groups	1130:1152	Similar chemical groups were characterized by FTIR in both SWE and CE pectins.
33807800	0	53	theme	Pectin	55:60	arg1	Properties					41:50	Physicochemical, Thermal and Rheological Properties	0:50	Physicochemical, Thermal and Rheological Properties of Pectin	0:60	Physicochemical, Thermal and Rheological Properties of Pectin Extracted from Sugar Beet Pulp Using Subcritical Water Extraction Process.
33807800	1	54	theme	conventional	286:297	arg1	CE					311:312	CE	311:312	CE	311:312	The objective of this study was to characterize the properties of pectin extracted from sugar beet pulp using subcritical water (SWE) as compared to conventional extraction (CE).
33807800	1	54	theme	conventional	286:297	arg1	extraction					299:308	conventional extraction	286:308	conventional extraction (CE)	286:313	The objective of this study was to characterize the properties of pectin extracted from sugar beet pulp using subcritical water (SWE) as compared to conventional extraction (CE).
33807800	5	55	theme	optimal	684:690	arg1	ratio					734:738	liquid-to-solid (L/S) ratio	712:738	liquid-to-solid (L/S) ratio of 30% (v/w)	712:751	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	5	55	theme	optimal	684:690	arg1	conditions					696:705	The optimal SWE conditions	680:705	The optimal SWE conditions	680:705	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	8	56	theme	CE	1197:1198	arg1	pectins					1200:1206	CE pectins	1197:1206	CE pectins	1197:1206	Similar chemical groups were characterized by FTIR in both SWE and CE pectins.
33807800	4	57	theme	pectin	648:653	arg1	yield					664:668	pectin recovery yield	648:668	pectin recovery yield of 20.8%	648:677	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	5	58	theme	L/S	729:731	arg1	ratio					734:738	liquid-to-solid (L/S) ratio	712:738	liquid-to-solid (L/S) ratio of 30% (v/w)	712:751	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	5	58	theme	L/S	729:731	arg1	conditions					696:705	The optimal SWE conditions	680:705	The optimal SWE conditions	680:705	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	10	59	theme	pectins	1269:1275	arg1	Solutions					1256:1264	Solutions	1256:1264	Solutions of pectins at lower concentrations	1256:1299	Solutions of pectins at lower concentrations displayed nearly Newtonian behavior.
33807800	12	60	theme	value-added	1544:1554	arg1	waste					1523:1527	the beet waste	1514:1527	the beet waste to pectin	1514:1537	The results offered a promising scalable approach to convert the beet waste to pectin as a value-added product using SWE with improved pectin properties.
33807800	12	60	theme	value-added	1544:1554	arg1	product					1556:1562	a value-added product	1542:1562	a value-added product using SWE with improved pectin properties	1542:1604	The results offered a promising scalable approach to convert the beet waste to pectin as a value-added product using SWE with improved pectin properties.
33807800	9	61	theme	Color	1209:1213	arg1	attributes					1215:1224	Color attributes	1209:1224	Color attributes of both pectins	1209:1240	Color attributes of both pectins were similar.
33807800	8	62	from	FTIR	1176:1179	arg1	SWE					1189:1191	SWE	1189:1191	SWE	1189:1191	Similar chemical groups were characterized by FTIR in both SWE and CE pectins.
33807800	8	62	from	FTIR	1176:1179	arg1	pectins					1200:1206	CE pectins	1197:1206	CE pectins	1197:1206	Similar chemical groups were characterized by FTIR in both SWE and CE pectins.
33807800	7	63	theme	methylation	997:1007	arg1	acid					981:984	galacturonic acid	968:984	galacturonic acid	968:984	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
33807800	7	63	theme	methylation	997:1007	arg1	degree					987:992	degree	987:992	degree of methylation, acetylation, and ferulic acid content	987:1046	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
33807800	6	64	theme	pasting	887:893	arg1	parameters					911:920	viscoamylograph pasting and DSC thermal parameters	871:920	viscoamylograph pasting and DSC thermal parameters of corn starch	871:935	The effect of obtained pectins on viscoamylograph pasting and DSC thermal parameters of corn starch was evaluated.
33807800	7	65	theme	molecular	1102:1110	arg1	weight					1112:1117	the molecular weight	1098:1117	the molecular weight	1098:1117	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
33807800	7	65	theme	molecular	1102:1110	arg1	lower					1123:1127	lower	1123:1127	lower	1123:1127	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
33807800	5	66	from	temperature	756:766	arg1	ratio					734:738	liquid-to-solid (L/S) ratio	712:738	liquid-to-solid (L/S) ratio of 30% (v/w)	712:751	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	5	66	from	temperature	756:766	arg1	conditions					696:705	The optimal SWE conditions	680:705	The optimal SWE conditions	680:705	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	12	67	theme	scalable	1485:1492	arg1	approach					1494:1501	a promising scalable approach	1473:1501	a promising scalable approach to convert the beet waste to pectin as a value-added product using SWE with improved pectin properties	1473:1604	The results offered a promising scalable approach to convert the beet waste to pectin as a value-added product using SWE with improved pectin properties.
33807800	3	68	theme	pectin	479:484	arg1	yield					470:474	maximum yield	462:474	maximum yield of pectin	462:484	The optimal conditions for maximum yield of pectin for SWE and CE methods were determined by the central composite design.
33807800	11	69	theme	pectins	1359:1365	arg1	addition					1342:1349	The addition	1338:1349	The addition of both pectins to corn starch	1338:1380	The addition of both pectins to corn starch decreased pasting and DSC gelatinization parameters, but increased ΔH.
33807800	1	70	theme	sugar	225:229	arg1	beet					231:234	sugar beet	225:234	sugar beet pulp using subcritical water (SWE) as compared to conventional extraction (CE)	225:313	The objective of this study was to characterize the properties of pectin extracted from sugar beet pulp using subcritical water (SWE) as compared to conventional extraction (CE).
33807800	12	71	with	SWE	1570:1572	arg1	properties					1595:1604	improved pectin properties	1579:1604	improved pectin properties	1579:1604	The results offered a promising scalable approach to convert the beet waste to pectin as a value-added product using SWE with improved pectin properties.
33807800	3	72	theme	maximum	462:468	arg1	yield					470:474	maximum yield	462:474	maximum yield of pectin	462:484	The optimal conditions for maximum yield of pectin for SWE and CE methods were determined by the central composite design.
33807800	5	73	theme	°C	775:776	arg1	temperature					756:766	temperature	756:766	temperature of 130 °C	756:776	The optimal SWE conditions were liquid-to-solid (L/S) ratio of 30% (v/w) at temperature of 130 °C for 20 min, which resulted in a comparable yield of 20.7%.
33807800	3	74	theme	optimal	439:445	arg1	conditions					447:456	The optimal conditions	435:456	The optimal conditions for maximum yield of pectin for SWE and CE methods	435:507	The optimal conditions for maximum yield of pectin for SWE and CE methods were determined by the central composite design.
33807800	1	75	theme	beet	231:234	arg1	pulp					236:239	sugar beet pulp	225:239	sugar beet pulp using subcritical water (SWE) as compared to conventional extraction (CE)	225:313	The objective of this study was to characterize the properties of pectin extracted from sugar beet pulp using subcritical water (SWE) as compared to conventional extraction (CE).
33807800	4	76	theme	CE	584:585	arg1	temperature					596:606	the temperature	592:606	the temperature of 90 °C	592:615	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	4	76	theme	CE	584:585	arg1	conditions					570:579	The optimum conditions	558:579	The optimum conditions of CE	558:585	The optimum conditions of CE were the temperature of 90 °C, time of 240 min, pH of 1, and pectin recovery yield of 20.8%.
33807800	7	77	theme	content	1040:1046	arg1	acid					981:984	galacturonic acid	968:984	galacturonic acid	968:984	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
33807800	7	77	theme	content	1040:1046	arg1	degree					987:992	degree	987:992	degree of methylation, acetylation, and ferulic acid content	987:1046	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
33807800	0	78	theme	Thermal	17:23	arg1	Properties					41:50	Physicochemical, Thermal and Rheological Properties	0:50	Physicochemical, Thermal and Rheological Properties of Pectin	0:60	Physicochemical, Thermal and Rheological Properties of Pectin Extracted from Sugar Beet Pulp Using Subcritical Water Extraction Process.
33807800	2	79	theme	advanced	338:345	arg1	modeling					347:354	advanced modeling	338:354	advanced modeling using response surface methodology and optimization of operational parameters	338:432	The research involved advanced modeling using response surface methodology and optimization of operational parameters.
33807800	7	80	theme	acid	1035:1038	arg1	content					1040:1046	ferulic acid content	1027:1046	ferulic acid content	1027:1046	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
33807800	7	81	theme	acid	981:984	arg1	contents					956:963	The contents	952:963	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content	952:1046	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
33807800	7	81	theme	acid	981:984	arg1	higher					1053:1058	higher	1053:1058	higher	1053:1058	The contents of galacturonic acid, degree of methylation, acetylation, and ferulic acid content were higher in the pectin extracted by SWE, while the molecular weight was lower.
34942463	7	0	theme	PMB	1120:1122	arg1	actions					1109:1115	Such actions	1104:1115	Such actions of PMB	1104:1122	Such actions of PMB influence the structure and lipid mobility of the membrane.
34942463	4	1	theme	lipid	583:587	arg1	species					589:595	specific lipid species	574:595	specific lipid species	574:595	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	8	2	from	homogeneous	1417:1427	arg1	space					1447:1451	the trajectory space	1432:1451	the trajectory space	1432:1451	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	9	3	theme	membrane	1520:1527	arg1	level					1529:1533	a membrane level	1518:1533	a membrane level	1518:1533	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	8	4	theme	OM-bound	1203:1210	arg1	PMB					1212:1214	the OM-bound PMB	1199:1214	the OM-bound PMB	1199:1214	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	8	5	from	space	1447:1451	arg1	homogeneous					1417:1427	homogeneous	1417:1427	homogeneous	1417:1427	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	2	6	theme	membrane	251:258	arg1	actions					260:266	the membrane actions	247:266	the membrane actions of PMB at a molecular level	247:294	However, thorough understanding of the membrane actions of PMB at a molecular level is still lacking.
34942463	1	7	theme	last-line	142:150	arg1	therapy					152:158	a last-line therapy	140:158	a last-line therapy against life-threatening Gram-negative "superbugs"	140:209	Polymyxin B (PMB) is clinically used as a last-line therapy against life-threatening Gram-negative "superbugs".
34942463	1	7	theme	last-line	142:150	arg1	B					110:110	Polymyxin B	100:110	Polymyxin B (PMB)	100:116	Polymyxin B (PMB) is clinically used as a last-line therapy against life-threatening Gram-negative "superbugs".
34942463	4	8	theme	mutant	671:676	arg1	preference					706:715	the rough mutant lipipolysacchrides (Re LPS) preference	661:715	the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM)	661:804	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	2	9	theme	molecular	280:288	arg1	level					290:294	a molecular level	278:294	a molecular level	278:294	However, thorough understanding of the membrane actions of PMB at a molecular level is still lacking.
34942463	1	10	theme	Gram-negative	185:197	arg1	"					209:209	life-threatening Gram-negative "superbugs"	168:209	life-threatening Gram-negative "superbugs"	168:209	Polymyxin B (PMB) is clinically used as a last-line therapy against life-threatening Gram-negative "superbugs".
34942463	5	11	theme	interaction	871:881	arg1	result					812:817	a result	810:817	a result of the lipid-specific actions	810:847	As a result of the lipid-specific actions, complicated membrane interaction states of PMB were observed, including adsorption on the OM surface.
34942463	5	11	theme	interaction	871:881	arg1	states					883:888	complicated membrane interaction states	850:888	complicated membrane interaction states of PMB	850:895	As a result of the lipid-specific actions, complicated membrane interaction states of PMB were observed, including adsorption on the OM surface.
34942463	3	12	with	interactions	421:432	arg1	PMB					439:441	PMB	439:441	PMB	439:441	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	3	13	from	work	322:325	arg1	mimics					360:365	bacterial membrane mimics	341:365	bacterial membrane mimics with varying lipid compositions	341:397	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	3	13	from	work	322:325	arg1	built					404:408	built	404:408	built	404:408	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	3	13	from	work	322:325	arg1	variety					330:336	a variety	328:336	a variety of bacterial membrane mimics with varying lipid compositions	328:397	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	1	14	theme	superbugs	200:208	arg1	"					209:209	life-threatening Gram-negative "superbugs"	168:209	life-threatening Gram-negative "superbugs"	168:209	Polymyxin B (PMB) is clinically used as a last-line therapy against life-threatening Gram-negative "superbugs".
34942463	8	15	dep	makes	1293:1297	arg1	diffuse					1304:1310	diffuse	1304:1310	diffuse	1304:1310	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	9	16	theme	polymyxin	1583:1591	arg1	strategies					1593:1602	novel and safer polymyxin strategies	1567:1602	novel and safer polymyxin strategies for better clinical use	1567:1626	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	8	17	from	movement	1239:1246	arg1	leaflet					1281:1287	the outer leaflet	1271:1287	the outer leaflet	1271:1287	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	2	18	theme	thorough	221:228	arg1	understanding					230:242	thorough understanding	221:242	thorough understanding of the membrane actions of PMB at a molecular level	221:294	However, thorough understanding of the membrane actions of PMB at a molecular level is still lacking.
34942463	5	19	theme	actions	841:847	arg1	result					812:817	a result	810:817	a result of the lipid-specific actions	810:847	As a result of the lipid-specific actions, complicated membrane interaction states of PMB were observed, including adsorption on the OM surface.
34942463	5	19	theme	actions	841:847	arg1	states					883:888	complicated membrane interaction states	850:888	complicated membrane interaction states of PMB	850:895	As a result of the lipid-specific actions, complicated membrane interaction states of PMB were observed, including adsorption on the OM surface.
34942463	9	20	theme	clinical	1615:1622	arg1	use					1624:1626	better clinical use	1608:1626	better clinical use	1608:1626	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	6	21	contain	containing	993:1002	arg2	lipids					1014:1019	impurity lipids	1005:1019	"impurity lipids" like POPE, POPG or lipid A	1004:1047	In contrast, for the IM or a mutative OM containing "impurity lipids" like POPE, POPG or lipid A, it could insert into the membrane via its acyl chain.
34942463	6	21	contain	containing	993:1002	arg1	IM					973:974	the IM	969:974	the IM	969:974	In contrast, for the IM or a mutative OM containing "impurity lipids" like POPE, POPG or lipid A, it could insert into the membrane via its acyl chain.
34942463	4	22	theme	LPS	701:703	arg1	preference					706:715	the rough mutant lipipolysacchrides (Re LPS) preference	661:715	the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM)	661:804	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	7	23	theme	Such	1104:1107	arg1	actions					1109:1115	Such actions	1104:1115	Such actions of PMB	1104:1122	Such actions of PMB influence the structure and lipid mobility of the membrane.
34942463	4	24	from	cardiolipin	750:760	arg1	membrane					792:799	an inner membrane	783:799	an inner membrane	783:799	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	5	25	theme	complicated	850:860	arg1	result					812:817	a result	810:817	a result of the lipid-specific actions	810:847	As a result of the lipid-specific actions, complicated membrane interaction states of PMB were observed, including adsorption on the OM surface.
34942463	5	25	theme	complicated	850:860	arg1	states					883:888	complicated membrane interaction states	850:888	complicated membrane interaction states of PMB	850:895	As a result of the lipid-specific actions, complicated membrane interaction states of PMB were observed, including adsorption on the OM surface.
34942463	2	26	from	level	290:294	arg1	understanding					230:242	thorough understanding	221:242	thorough understanding of the membrane actions of PMB at a molecular level	221:294	However, thorough understanding of the membrane actions of PMB at a molecular level is still lacking.
34942463	2	26	from	level	290:294	arg1	actions					260:266	the membrane actions	247:266	the membrane actions of PMB at a molecular level	247:294	However, thorough understanding of the membrane actions of PMB at a molecular level is still lacking.
34942463	7	27	dep	structure	1138:1146	arg1	the					1134:1136	the	1134:1136	the	1134:1136	Such actions of PMB influence the structure and lipid mobility of the membrane.
34942463	0	28	theme	dynamics	84:91	arg1	study					93:97	A molecular dynamics study	72:97	A molecular dynamics study	72:97	Interactions between polymyxin B and various bacterial membrane mimics: A molecular dynamics study.
34942463	1	29	used	used	132:135	arg2	B					110:110	Polymyxin B	100:110	Polymyxin B (PMB)	100:116	Polymyxin B (PMB) is clinically used as a last-line therapy against life-threatening Gram-negative "superbugs".
34942463	1	29	used	used	132:135	arg2	therapy					152:158	a last-line therapy	140:158	a last-line therapy against life-threatening Gram-negative "superbugs"	140:209	Polymyxin B (PMB) is clinically used as a last-line therapy against life-threatening Gram-negative "superbugs".
34942463	1	29	used	used	132:135	arg2	PMB					113:115	PMB	113:115	PMB	113:115	Polymyxin B (PMB) is clinically used as a last-line therapy against life-threatening Gram-negative "superbugs".
34942463	8	30	theme	synchronous	1227:1237	arg1	movement					1239:1246	the synchronous movement	1223:1246	the synchronous movement of Re LPS molecules in the outer leaflet	1223:1287	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	6	31	from	insert	1059:1064	arg1	contrast					955:962	contrast	955:962	contrast	955:962	In contrast, for the IM or a mutative OM containing "impurity lipids" like POPE, POPG or lipid A, it could insert into the membrane via its acyl chain.
34942463	3	32	theme	lipid	380:384	arg1	compositions					386:397	varying lipid compositions	372:397	varying lipid compositions	372:397	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	4	33	from	membrane	729:736	arg1	membrane					792:799	an inner membrane	783:799	an inner membrane	783:799	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	2	34	from	understanding	230:242	arg1	level					290:294	a molecular level	278:294	a molecular level	278:294	However, thorough understanding of the membrane actions of PMB at a molecular level is still lacking.
34942463	8	35	theme	LPS	1254:1256	arg1	molecules					1258:1266	Re LPS molecules	1251:1266	Re LPS molecules	1251:1266	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	0	36	theme	polymyxin	21:29	arg1	B					31:31	polymyxin B	21:31	polymyxin B	21:31	Interactions between polymyxin B and various bacterial membrane mimics: A molecular dynamics study.
34942463	2	37	theme	actions	260:266	arg1	understanding					230:242	thorough understanding	221:242	thorough understanding of the membrane actions of PMB at a molecular level	221:294	However, thorough understanding of the membrane actions of PMB at a molecular level is still lacking.
34942463	1	38	theme	Polymyxin	100:108	arg1	PMB					113:115	PMB	113:115	PMB	113:115	Polymyxin B (PMB) is clinically used as a last-line therapy against life-threatening Gram-negative "superbugs".
34942463	1	38	theme	Polymyxin	100:108	arg1	therapy					152:158	a last-line therapy	140:158	a last-line therapy against life-threatening Gram-negative "superbugs"	140:209	Polymyxin B (PMB) is clinically used as a last-line therapy against life-threatening Gram-negative "superbugs".
34942463	1	38	theme	Polymyxin	100:108	arg1	B					110:110	Polymyxin B	100:110	Polymyxin B (PMB)	100:116	Polymyxin B (PMB) is clinically used as a last-line therapy against life-threatening Gram-negative "superbugs".
34942463	8	39	theme	homogeneous	1417:1427	arg1	membrane					1403:1410	the membrane	1399:1410	the membrane more homogeneous in the trajectory space	1399:1451	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	4	40	theme	inner	786:790	arg1	membrane					792:799	an inner membrane	783:799	an inner membrane	783:799	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	7	41	theme	membrane	1174:1181	arg1	structure					1138:1146	structure	1138:1146	structure	1138:1146	Such actions of PMB influence the structure and lipid mobility of the membrane.
34942463	7	41	theme	membrane	1174:1181	arg1	mobility					1158:1165	lipid mobility	1152:1165	lipid mobility	1152:1165	Such actions of PMB influence the structure and lipid mobility of the membrane.
34942463	3	42	theme	membrane	351:358	arg1	mimics					360:365	bacterial membrane mimics	341:365	bacterial membrane mimics with varying lipid compositions	341:397	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	8	43	theme	outer	1275:1279	arg1	leaflet					1281:1287	the outer leaflet	1271:1287	the outer leaflet	1271:1287	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	0	44	theme	bacterial	45:53	arg1	mimics					64:69	various bacterial membrane mimics	37:69	various bacterial membrane mimics	37:69	Interactions between polymyxin B and various bacterial membrane mimics: A molecular dynamics study.
34942463	4	45	theme	POPG	766:769	arg1	affinity					771:778	POPG affinity	766:778	POPG affinity	766:778	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	7	46	theme	lipid	1152:1156	arg1	mobility					1158:1165	lipid mobility	1152:1165	lipid mobility	1152:1165	Such actions of PMB influence the structure and lipid mobility of the membrane.
34942463	3	47	theme	coarse-grained	482:495	arg1	simulation					516:525	coarse-grained molecular dynamics simulation	482:525	coarse-grained molecular dynamics simulation	482:525	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	3	48	from	built	404:408	arg1	work					322:325	this work	317:325	this work	317:325	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	9	49	theme	PMB	1511:1513	arg1	foundation					1541:1550	a foundation	1539:1550	a foundation for developing novel and safer polymyxin strategies for better clinical use	1539:1626	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	9	49	theme	PMB	1511:1513	arg1	mechanism					1498:1506	the action mechanism	1487:1506	the action mechanism of PMB at a membrane level	1487:1533	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	4	50	theme	specific	574:581	arg1	species					589:595	specific lipid species	574:595	specific lipid species	574:595	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	2	51	theme	PMB	271:273	arg1	actions					260:266	the membrane actions	247:266	the membrane actions of PMB at a molecular level	247:294	However, thorough understanding of the membrane actions of PMB at a molecular level is still lacking.
34942463	5	52	from	adsorption	922:931	arg1	surface					943:949	the OM surface	936:949	the OM surface	936:949	As a result of the lipid-specific actions, complicated membrane interaction states of PMB were observed, including adsorption on the OM surface.
34942463	3	53	with	mimics	360:365	arg1	compositions					386:397	varying lipid compositions	372:397	varying lipid compositions	372:397	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	3	54	theme	dynamics	507:514	arg1	simulation					516:525	coarse-grained molecular dynamics simulation	482:525	coarse-grained molecular dynamics simulation	482:525	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	4	55	theme	rough	665:669	arg1	preference					706:715	the rough mutant lipipolysacchrides (Re LPS) preference	661:715	the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM)	661:804	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	1	56	theme	life-threatening	168:183	arg1	"					209:209	life-threatening Gram-negative "superbugs"	168:209	life-threatening Gram-negative "superbugs"	168:209	Polymyxin B (PMB) is clinically used as a last-line therapy against life-threatening Gram-negative "superbugs".
34942463	4	57	theme	membrane	635:642	arg1	preference					706:715	the rough mutant lipipolysacchrides (Re LPS) preference	661:715	the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM)	661:804	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	4	57	theme	membrane	635:642	arg1	systems					644:650	different membrane systems	625:650	different membrane systems	625:650	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	9	58	theme	novel	1567:1571	arg1	strategies					1593:1602	novel and safer polymyxin strategies	1567:1602	novel and safer polymyxin strategies for better clinical use	1567:1626	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	4	59	with	interaction	608:618	arg1	preference					706:715	the rough mutant lipipolysacchrides (Re LPS) preference	661:715	the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM)	661:804	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	4	59	with	interaction	608:618	arg1	systems					644:650	different membrane systems	625:650	different membrane systems	625:650	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	5	60	theme	membrane	862:869	arg1	result					812:817	a result	810:817	a result of the lipid-specific actions	810:847	As a result of the lipid-specific actions, complicated membrane interaction states of PMB were observed, including adsorption on the OM surface.
34942463	5	60	theme	membrane	862:869	arg1	states					883:888	complicated membrane interaction states	850:888	complicated membrane interaction states of PMB	850:895	As a result of the lipid-specific actions, complicated membrane interaction states of PMB were observed, including adsorption on the OM surface.
34942463	9	61	theme	safer	1577:1581	arg1	strategies					1593:1602	novel and safer polymyxin strategies	1567:1602	novel and safer polymyxin strategies for better clinical use	1567:1626	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	6	62	theme	acyl	1092:1095	arg1	chain					1097:1101	its acyl chain	1088:1101	its acyl chain	1088:1101	In contrast, for the IM or a mutative OM containing "impurity lipids" like POPE, POPG or lipid A, it could insert into the membrane via its acyl chain.
34942463	4	63	from	affinity	771:778	arg1	membrane					792:799	an inner membrane	783:799	an inner membrane	783:799	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	5	64	theme	lipid-specific	826:839	arg1	actions					841:847	the lipid-specific actions	822:847	the lipid-specific actions	822:847	As a result of the lipid-specific actions, complicated membrane interaction states of PMB were observed, including adsorption on the OM surface.
34942463	9	65	theme	better	1608:1613	arg1	use					1624:1626	better clinical use	1608:1626	better clinical use	1608:1626	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	4	66	theme	lipipolysacchrides	678:695	arg1	preference					706:715	the rough mutant lipipolysacchrides (Re LPS) preference	661:715	the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM)	661:804	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	0	67	theme	molecular	74:82	arg1	study					93:97	A molecular dynamics study	72:97	A molecular dynamics study	72:97	Interactions between polymyxin B and various bacterial membrane mimics: A molecular dynamics study.
34942463	8	68	theme	phospholipid	1366:1377	arg1	diffusion					1379:1387	the phospholipid diffusion	1362:1387	the phospholipid diffusion	1362:1387	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	4	69	theme	Re	698:699	arg1	preference					706:715	the rough mutant lipipolysacchrides (Re LPS) preference	661:715	the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM)	661:804	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	9	70	from	foundation	1541:1550	arg1	level					1529:1533	a membrane level	1518:1533	a membrane level	1518:1533	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	0	71	dep	study	93:97	arg1	Interactions					0:11	Interactions	0:11	Interactions between polymyxin B and various bacterial membrane mimics	0:69	Interactions between polymyxin B and various bacterial membrane mimics: A molecular dynamics study.
34942463	8	72	from	breaks	1216:1221	arg1	particular					1187:1196	particular	1187:1196	particular	1187:1196	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	6	73	theme	impurity	1005:1012	arg1	lipids					1014:1019	impurity lipids	1005:1019	"impurity lipids" like POPE, POPG or lipid A	1004:1047	In contrast, for the IM or a mutative OM containing "impurity lipids" like POPE, POPG or lipid A, it could insert into the membrane via its acyl chain.
34942463	9	74	from	level	1529:1533	arg1	foundation					1541:1550	a foundation	1539:1550	a foundation for developing novel and safer polymyxin strategies for better clinical use	1539:1626	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	9	74	from	level	1529:1533	arg1	PMB					1511:1513	PMB	1511:1513	PMB at a membrane level	1511:1533	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	9	74	from	level	1529:1533	arg1	mechanism					1498:1506	the action mechanism	1487:1506	the action mechanism of PMB at a membrane level	1487:1533	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	5	75	theme	PMB	893:895	arg1	result					812:817	a result	810:817	a result of the lipid-specific actions	810:847	As a result of the lipid-specific actions, complicated membrane interaction states of PMB were observed, including adsorption on the OM surface.
34942463	5	75	theme	PMB	893:895	arg1	states					883:888	complicated membrane interaction states	850:888	complicated membrane interaction states of PMB	850:895	As a result of the lipid-specific actions, complicated membrane interaction states of PMB were observed, including adsorption on the OM surface.
34942463	3	76	theme	bacterial	341:349	arg1	mimics					360:365	bacterial membrane mimics	341:365	bacterial membrane mimics with varying lipid compositions	341:397	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	4	77	theme	characteristic	545:558	arg1	preference					560:569	characteristic preference	545:569	characteristic preference to specific lipid species	545:595	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	4	78	theme	outer	723:727	arg1	OM					739:740	OM	739:740	OM	739:740	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	4	78	theme	outer	723:727	arg1	membrane					729:736	an outer membrane	720:736	an outer membrane (OM)	720:741	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	6	79	theme	mutative	981:988	arg1	OM					990:991	a mutative OM	979:991	a mutative OM	979:991	In contrast, for the IM or a mutative OM containing "impurity lipids" like POPE, POPG or lipid A, it could insert into the membrane via its acyl chain.
34942463	8	80	theme	Re	1251:1252	arg1	molecules					1258:1266	Re LPS molecules	1251:1266	Re LPS molecules	1251:1266	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	0	81	theme	various	37:43	arg1	mimics					64:69	various bacterial membrane mimics	37:69	various bacterial membrane mimics	37:69	Interactions between polymyxin B and various bacterial membrane mimics: A molecular dynamics study.
34942463	9	82	from	mechanism	1498:1506	arg1	level					1529:1533	a membrane level	1518:1533	a membrane level	1518:1533	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	3	83	theme	varying	372:378	arg1	compositions					386:397	varying lipid compositions	372:397	varying lipid compositions	372:397	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	8	84	theme	trajectory	1436:1445	arg1	space					1447:1451	the trajectory space	1432:1451	the trajectory space	1432:1451	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	8	85	theme	molecules	1258:1266	arg1	movement					1239:1246	the synchronous movement	1223:1246	the synchronous movement of Re LPS molecules in the outer leaflet	1223:1287	In particular, the OM-bound PMB breaks the synchronous movement of Re LPS molecules in the outer leaflet and makes them diffuse more randomly, while its insertion into IM blocks the phospholipid diffusion and makes the membrane more homogeneous in the trajectory space.
34942463	0	86	theme	membrane	55:62	arg1	mimics					64:69	various bacterial membrane mimics	37:69	various bacterial membrane mimics	37:69	Interactions between polymyxin B and various bacterial membrane mimics: A molecular dynamics study.
34942463	6	87	theme	lipid	1041:1045	arg1	A					1047:1047	lipid A	1041:1047	lipid A	1041:1047	In contrast, for the IM or a mutative OM containing "impurity lipids" like POPE, POPG or lipid A, it could insert into the membrane via its acyl chain.
34942463	3	88	theme	mimics	360:365	arg1	mimics					360:365	bacterial membrane mimics	341:365	bacterial membrane mimics with varying lipid compositions	341:397	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	3	88	theme	mimics	360:365	arg1	built					404:408	built	404:408	built	404:408	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	3	88	theme	mimics	360:365	arg1	variety					330:336	a variety	328:336	a variety of bacterial membrane mimics with varying lipid compositions	328:397	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
34942463	5	89	theme	OM	940:941	arg1	surface					943:949	the OM surface	936:949	the OM surface	936:949	As a result of the lipid-specific actions, complicated membrane interaction states of PMB were observed, including adsorption on the OM surface.
34942463	4	90	from	preference	706:715	arg1	IM					802:803	IM	802:803	IM	802:803	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	4	90	from	preference	706:715	arg1	OM					739:740	OM	739:740	OM	739:740	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	4	90	from	preference	706:715	arg1	membrane					729:736	an outer membrane	720:736	an outer membrane (OM)	720:741	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	4	90	from	preference	706:715	arg1	cardiolipin					750:760	the cardiolipin	746:760	the cardiolipin	746:760	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	9	91	theme	action	1491:1496	arg1	mechanism					1498:1506	the action mechanism	1487:1506	the action mechanism of PMB at a membrane level	1487:1533	Our results provide insight into the action mechanism of PMB at a membrane level and a foundation for developing novel and safer polymyxin strategies for better clinical use.
34942463	4	92	theme	different	625:633	arg1	preference					706:715	the rough mutant lipipolysacchrides (Re LPS) preference	661:715	the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM)	661:804	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	4	92	theme	different	625:633	arg1	systems					644:650	different membrane systems	625:650	different membrane systems	625:650	PMB demonstrated characteristic preference to specific lipid species during its interaction with different membrane systems, such as the rough mutant lipipolysacchrides (Re LPS) preference in an outer membrane (OM) or the cardiolipin and POPG affinity in an inner membrane (IM).
34942463	3	93	theme	molecular	497:505	arg1	simulation					516:525	coarse-grained molecular dynamics simulation	482:525	coarse-grained molecular dynamics simulation	482:525	In this work, a variety of bacterial membrane mimics with varying lipid compositions were built, and their interactions with PMB were systematically investigated using coarse-grained molecular dynamics simulation.
32172865	3	0	dep	hemostasis	626:635	arg1	effect					637:642	effect	637:642	given effective hemostasis effect (clotting time shortened by 70 % than that of control)	610:697	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	0	dep	hemostasis	626:635	arg1	time					654:657	clotting time	645:657	clotting time shortened by 70 % than that of control	645:696	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	4	1	theme	blood	914:918	arg1	coagulation					920:930	accelerated blood coagulation	902:930	accelerated blood coagulation	902:930	In vitro coagulation tests demonstrated that H-D could provide strong interface effect to induce erythrocyte absorption and aggregation, as well as activating the intrinsic coagulation pathway and thus accelerated blood coagulation.
32172865	5	2	theme	composite	963:971	arg1	sponge					973:978	H-D composite sponge	959:978	H-D composite sponge	959:978	These results proved that H-D composite sponge has great potential for hemorrhage control.
32172865	1	3	theme	Effective	80:88	arg1	control					99:105	Effective bleeding control	80:105	Effective bleeding control	80:105	Effective bleeding control is critical first step in current civilian and military trauma treatment, however commercially available hemostatic materials are difficult to achieve expected effects.
32172865	1	4	theme	critical	110:117	arg1	step					125:128	critical first step	110:128	critical first step in current civilian and military trauma treatment	110:178	Effective bleeding control is critical first step in current civilian and military trauma treatment, however commercially available hemostatic materials are difficult to achieve expected effects.
32172865	1	5	theme	bleeding	90:97	arg1	control					99:105	Effective bleeding control	80:105	Effective bleeding control	80:105	Effective bleeding control is critical first step in current civilian and military trauma treatment, however commercially available hemostatic materials are difficult to achieve expected effects.
32172865	3	6	theme	ratio	499:503	arg1	%					509:509	hemolysis ratio < 5 %	489:509	hemolysis ratio < 5 %	489:509	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	6	theme	ratio	499:503	arg1	cytotoxicity					515:526	no cytotoxicity	512:526	no cytotoxicity	512:526	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	1	7	theme	current	133:139	arg1	treatment					170:178	current civilian and military trauma treatment	133:178	current civilian and military trauma treatment	133:178	Effective bleeding control is critical first step in current civilian and military trauma treatment, however commercially available hemostatic materials are difficult to achieve expected effects.
32172865	4	8	theme	erythrocyte	797:807	arg1	absorption					809:818	erythrocyte absorption	797:818	erythrocyte absorption	797:818	In vitro coagulation tests demonstrated that H-D could provide strong interface effect to induce erythrocyte absorption and aggregation, as well as activating the intrinsic coagulation pathway and thus accelerated blood coagulation.
32172865	3	9	theme	porous	443:448	arg1	structure					450:458	hierarchical porous structure	430:458	hierarchical porous structure	430:458	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	9	theme	porous	443:448	arg1	biocompatibility					471:486	favorable biocompatibility	461:486	favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity)	461:527	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	2	10	theme	composite	293:301	arg1	H-D					311:313	H-D	311:313	H-D	311:313	In this study, a composite sponge (H-D) based on hydroxybutyl chitosan (HBC) and diatom-biosilica (DB) was designed for hemorrhage control.
32172865	2	10	theme	composite	293:301	arg1	sponge					303:308	a composite sponge	291:308	a composite sponge (H-D) based on hydroxybutyl chitosan (HBC) and diatom-biosilica (DB)	291:377	In this study, a composite sponge (H-D) based on hydroxybutyl chitosan (HBC) and diatom-biosilica (DB) was designed for hemorrhage control.
32172865	1	11	theme	available	202:210	arg1	materials					223:231	commercially available hemostatic materials	189:231	commercially available hemostatic materials	189:231	Effective bleeding control is critical first step in current civilian and military trauma treatment, however commercially available hemostatic materials are difficult to achieve expected effects.
32172865	4	12	dep	In	700:701	arg1	vitro					703:707	vitro	703:707	vitro	703:707	In vitro coagulation tests demonstrated that H-D could provide strong interface effect to induce erythrocyte absorption and aggregation, as well as activating the intrinsic coagulation pathway and thus accelerated blood coagulation.
32172865	2	13	theme	hydroxybutyl	325:336	arg1	HBC					348:350	HBC	348:350	HBC	348:350	In this study, a composite sponge (H-D) based on hydroxybutyl chitosan (HBC) and diatom-biosilica (DB) was designed for hemorrhage control.
32172865	2	13	theme	hydroxybutyl	325:336	arg1	chitosan					338:345	hydroxybutyl chitosan	325:345	hydroxybutyl chitosan (HBC)	325:351	In this study, a composite sponge (H-D) based on hydroxybutyl chitosan (HBC) and diatom-biosilica (DB) was designed for hemorrhage control.
32172865	1	14	theme	hemostatic	212:221	arg1	materials					223:231	commercially available hemostatic materials	189:231	commercially available hemostatic materials	189:231	Effective bleeding control is critical first step in current civilian and military trauma treatment, however commercially available hemostatic materials are difficult to achieve expected effects.
32172865	1	15	theme	first	119:123	arg1	step					125:128	critical first step	110:128	critical first step in current civilian and military trauma treatment	110:178	Effective bleeding control is critical first step in current civilian and military trauma treatment, however commercially available hemostatic materials are difficult to achieve expected effects.
32172865	3	16	theme	hierarchical	430:441	arg1	structure					450:458	hierarchical porous structure	430:458	hierarchical porous structure	430:458	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	16	theme	hierarchical	430:441	arg1	biocompatibility					471:486	favorable biocompatibility	461:486	favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity)	461:527	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	17	theme	high	541:544	arg1	absorbability					561:573	high and fast fluid absorbability	541:573	high and fast fluid absorbability (11-16 times than that of weight)	541:607	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	17	theme	high	541:544	arg1	hemostasis					626:635	given effective hemostasis	610:635	given effective hemostasis effect (clotting time shortened by 70 % than that of control)	610:697	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	5	18	theme	great	984:988	arg1	potential					990:998	great potential	984:998	great potential for hemorrhage control	984:1021	These results proved that H-D composite sponge has great potential for hemorrhage control.
32172865	3	19	theme	fluid	555:559	arg1	absorbability					561:573	high and fast fluid absorbability	541:573	high and fast fluid absorbability (11-16 times than that of weight)	541:607	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	19	theme	fluid	555:559	arg1	hemostasis					626:635	given effective hemostasis	610:635	given effective hemostasis effect (clotting time shortened by 70 % than that of control)	610:697	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	4	20	theme	coagulation	873:883	arg1	pathway					885:891	the intrinsic coagulation pathway	859:891	the intrinsic coagulation pathway	859:891	In vitro coagulation tests demonstrated that H-D could provide strong interface effect to induce erythrocyte absorption and aggregation, as well as activating the intrinsic coagulation pathway and thus accelerated blood coagulation.
32172865	3	21	theme	given	610:614	arg1	absorbability					561:573	high and fast fluid absorbability	541:573	high and fast fluid absorbability (11-16 times than that of weight)	541:607	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	21	theme	given	610:614	arg1	hemostasis					626:635	given effective hemostasis	610:635	given effective hemostasis effect (clotting time shortened by 70 % than that of control)	610:697	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	0	22	theme	hemorrhage	60:69	arg1	control					71:77	hemorrhage control	60:77	hemorrhage control	60:77	Hydroxybutyl chitosan/diatom-biosilica composite sponge for hemorrhage control.
32172865	3	23	theme	effective	616:624	arg1	absorbability					561:573	high and fast fluid absorbability	541:573	high and fast fluid absorbability (11-16 times than that of weight)	541:607	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	23	theme	effective	616:624	arg1	hemostasis					626:635	given effective hemostasis	610:635	given effective hemostasis effect (clotting time shortened by 70 % than that of control)	610:697	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	4	24	theme	interface	770:778	arg1	effect					780:785	strong interface effect	763:785	strong interface effect	763:785	In vitro coagulation tests demonstrated that H-D could provide strong interface effect to induce erythrocyte absorption and aggregation, as well as activating the intrinsic coagulation pathway and thus accelerated blood coagulation.
32172865	3	25	dep	absorbability	561:573	arg1	times					582:586	11-16 times	576:586	11-16 times than that of weight	576:606	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	4	26	theme	strong	763:768	arg1	effect					780:785	strong interface effect	763:785	strong interface effect	763:785	In vitro coagulation tests demonstrated that H-D could provide strong interface effect to induce erythrocyte absorption and aggregation, as well as activating the intrinsic coagulation pathway and thus accelerated blood coagulation.
32172865	2	27	theme	hemorrhage	396:405	arg1	control					407:413	hemorrhage control	396:413	hemorrhage control	396:413	In this study, a composite sponge (H-D) based on hydroxybutyl chitosan (HBC) and diatom-biosilica (DB) was designed for hemorrhage control.
32172865	3	28	theme	<	505:505	arg1	%					509:509	hemolysis ratio < 5 %	489:509	hemolysis ratio < 5 %	489:509	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	28	theme	<	505:505	arg1	cytotoxicity					515:526	no cytotoxicity	512:526	no cytotoxicity	512:526	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	5	29	theme	hemorrhage	1004:1013	arg1	control					1015:1021	hemorrhage control	1004:1021	hemorrhage control	1004:1021	These results proved that H-D composite sponge has great potential for hemorrhage control.
32172865	1	30	theme	civilian	141:148	arg1	treatment					170:178	current civilian and military trauma treatment	133:178	current civilian and military trauma treatment	133:178	Effective bleeding control is critical first step in current civilian and military trauma treatment, however commercially available hemostatic materials are difficult to achieve expected effects.
32172865	1	31	from	step	125:128	arg1	treatment					170:178	current civilian and military trauma treatment	133:178	current civilian and military trauma treatment	133:178	Effective bleeding control is critical first step in current civilian and military trauma treatment, however commercially available hemostatic materials are difficult to achieve expected effects.
32172865	3	32	theme	fast	550:553	arg1	absorbability					561:573	high and fast fluid absorbability	541:573	high and fast fluid absorbability (11-16 times than that of weight)	541:607	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	32	theme	fast	550:553	arg1	hemostasis					626:635	given effective hemostasis	610:635	given effective hemostasis effect (clotting time shortened by 70 % than that of control)	610:697	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	4	33	theme	intrinsic	863:871	arg1	pathway					885:891	the intrinsic coagulation pathway	859:891	the intrinsic coagulation pathway	859:891	In vitro coagulation tests demonstrated that H-D could provide strong interface effect to induce erythrocyte absorption and aggregation, as well as activating the intrinsic coagulation pathway and thus accelerated blood coagulation.
32172865	3	34	theme	clotting	645:652	arg1	time					654:657	clotting time	645:657	clotting time shortened by 70 % than that of control	645:696	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	5	35	theme	H-D	959:961	arg1	sponge					973:978	H-D composite sponge	959:978	H-D composite sponge	959:978	These results proved that H-D composite sponge has great potential for hemorrhage control.
32172865	3	36	theme	hemolysis	489:497	arg1	%					509:509	hemolysis ratio < 5 %	489:509	hemolysis ratio < 5 %	489:509	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	36	theme	hemolysis	489:497	arg1	cytotoxicity					515:526	no cytotoxicity	512:526	no cytotoxicity	512:526	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	4	37	theme	In	700:701	arg1	tests					721:725	In vitro coagulation tests	700:725	In vitro coagulation tests	700:725	In vitro coagulation tests demonstrated that H-D could provide strong interface effect to induce erythrocyte absorption and aggregation, as well as activating the intrinsic coagulation pathway and thus accelerated blood coagulation.
32172865	1	38	theme	expected	258:265	arg1	effects					267:273	expected effects	258:273	expected effects	258:273	Effective bleeding control is critical first step in current civilian and military trauma treatment, however commercially available hemostatic materials are difficult to achieve expected effects.
32172865	4	39	theme	coagulation	709:719	arg1	tests					721:725	In vitro coagulation tests	700:725	In vitro coagulation tests	700:725	In vitro coagulation tests demonstrated that H-D could provide strong interface effect to induce erythrocyte absorption and aggregation, as well as activating the intrinsic coagulation pathway and thus accelerated blood coagulation.
32172865	1	40	theme	military	154:161	arg1	treatment					170:178	current civilian and military trauma treatment	133:178	current civilian and military trauma treatment	133:178	Effective bleeding control is critical first step in current civilian and military trauma treatment, however commercially available hemostatic materials are difficult to achieve expected effects.
32172865	3	41	theme	favorable	461:469	arg1	structure					450:458	hierarchical porous structure	430:458	hierarchical porous structure	430:458	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	41	theme	favorable	461:469	arg1	biocompatibility					471:486	favorable biocompatibility	461:486	favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity)	461:527	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	42	dep	biocompatibility	471:486	arg1	%					509:509	hemolysis ratio < 5 %	489:509	hemolysis ratio < 5 %	489:509	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	3	42	dep	biocompatibility	471:486	arg1	cytotoxicity					515:526	no cytotoxicity	512:526	no cytotoxicity	512:526	H-D exhibited hierarchical porous structure, favorable biocompatibility (hemolysis ratio < 5 %, no cytotoxicity), along with high and fast fluid absorbability (11-16 times than that of weight), given effective hemostasis effect (clotting time shortened by 70 % than that of control).
32172865	1	43	theme	trauma	163:168	arg1	treatment					170:178	current civilian and military trauma treatment	133:178	current civilian and military trauma treatment	133:178	Effective bleeding control is critical first step in current civilian and military trauma treatment, however commercially available hemostatic materials are difficult to achieve expected effects.
32172865	0	44	theme	composite	39:47	arg1	sponge					49:54	composite sponge	39:54	composite sponge for hemorrhage control	39:77	Hydroxybutyl chitosan/diatom-biosilica composite sponge for hemorrhage control.
32172865	5	45	contain	has	980:982	arg1	sponge					973:978	H-D composite sponge	959:978	H-D composite sponge	959:978	These results proved that H-D composite sponge has great potential for hemorrhage control.
32172865	5	45	contain	has	980:982	arg2	potential					990:998	great potential	984:998	great potential for hemorrhage control	984:1021	These results proved that H-D composite sponge has great potential for hemorrhage control.
32172865	4	46	theme	accelerated	902:912	arg1	coagulation					920:930	accelerated blood coagulation	902:930	accelerated blood coagulation	902:930	In vitro coagulation tests demonstrated that H-D could provide strong interface effect to induce erythrocyte absorption and aggregation, as well as activating the intrinsic coagulation pathway and thus accelerated blood coagulation.
35777914	3	0	theme	lung	581:584	arg1	A549					604:607	A549	604:607	A549	604:607	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	3	0	theme	lung	581:584	arg1	cells					597:601	human lung epithelial cells	575:601	human lung epithelial cells (A549)	575:608	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	10	1	from	production	1649:1658	arg1	PBECs					1663:1667	PBECs	1663:1667	PBECs	1663:1667	The M. haemolytica-induced IL-1β production in PBECs was lowered by GOS, which was associated with NLRP3 inflammasome inhibition caused by the decreased reactive oxygen species and ATP production.
35777914	13	2	theme	inflammasome	2047:2058	arg1	activation					2060:2069	the NLRP3 inflammasome activation	2037:2069	the NLRP3 inflammasome activation	2037:2069	CONCLUSION GOS exert anti-inflammatory properties by inhibiting the NLRP3 inflammasome activation in vitro and in vivo, suggesting a potential role for GOS in the prevention of lung infections.
35777914	10	3	theme	reactive	1769:1776	arg1	species					1785:1791	the decreased reactive oxygen species	1755:1791	the decreased reactive oxygen species	1755:1791	The M. haemolytica-induced IL-1β production in PBECs was lowered by GOS, which was associated with NLRP3 inflammasome inhibition caused by the decreased reactive oxygen species and ATP production.
35777914	11	4	from	production	1850:1859	arg1	PBECs					1864:1868	PBECs	1864:1868	PBECs	1864:1868	GOS inhibited leukotoxin-induced ATP production in PBECs.
35777914	13	5	theme	anti-inflammatory	1994:2010	arg1	properties					2012:2021	anti-inflammatory properties	1994:2021	anti-inflammatory properties	1994:2021	CONCLUSION GOS exert anti-inflammatory properties by inhibiting the NLRP3 inflammasome activation in vitro and in vivo, suggesting a potential role for GOS in the prevention of lung infections.
35777914	2	6	theme	due	325:327	arg1	galacto-oligosaccharides					268:291	Non-digestible galacto-oligosaccharides	253:291	Non-digestible galacto-oligosaccharides (GOS)	253:297	Non-digestible galacto-oligosaccharides (GOS) are attractive candidates due to their anti-inflammatory and immunomodulatory effects both locally and systemically.
35777914	2	6	theme	due	325:327	arg1	candidates					314:323	attractive candidates	303:323	attractive candidates due to their anti-inflammatory and immunomodulatory effects	303:383	Non-digestible galacto-oligosaccharides (GOS) are attractive candidates due to their anti-inflammatory and immunomodulatory effects both locally and systemically.
35777914	9	7	theme	response	1489:1496	arg1	suppression					1461:1471	suppression	1461:1471	suppression of inflammatory response	1461:1496	Regulation of immune function and suppression of inflammatory response by GOS is related to the inhibition of NLRP3 inflammasome as observed in bronchial mucosal tissue of infected calves.
35777914	9	7	theme	response	1489:1496	arg1	function					1448:1455	immune function	1441:1455	immune function	1441:1455	Regulation of immune function and suppression of inflammatory response by GOS is related to the inhibition of NLRP3 inflammasome as observed in bronchial mucosal tissue of infected calves.
35777914	6	8	theme	bronchial	1195:1203	arg1	mucosa					1205:1210	bronchial mucosa	1195:1210	bronchial mucosa	1195:1210	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	4	9	theme	NLR	684:686	arg1	domain					701:706	the NLR family pyrin domain	680:706	the NLR family pyrin domain containing 3 (NLRP3) inflammasome	680:740	To delineate the mechanism, the potential capacity of GOS to inhibit the NLR family pyrin domain containing 3 (NLRP3) inflammasome has been investigated.
35777914	10	10	theme	haemolytica-induced	1623:1641	arg1	production					1649:1658	The M. haemolytica-induced IL-1β production	1616:1658	The M. haemolytica-induced IL-1β production in PBECs	1616:1667	The M. haemolytica-induced IL-1β production in PBECs was lowered by GOS, which was associated with NLRP3 inflammasome inhibition caused by the decreased reactive oxygen species and ATP production.
35777914	10	11	theme	decreased	1759:1767	arg1	species					1785:1791	the decreased reactive oxygen species	1755:1791	the decreased reactive oxygen species	1755:1791	The M. haemolytica-induced IL-1β production in PBECs was lowered by GOS, which was associated with NLRP3 inflammasome inhibition caused by the decreased reactive oxygen species and ATP production.
35777914	1	12	theme	new	235:237	arg1	alternatives					239:250	new alternatives	235:250	new alternatives	235:250	INTRODUCTION The lack of effective anti-inflammatory therapies for pneumonia represents a challenge for identifying new alternatives.
35777914	6	13	theme	cell	991:994	arg1	composition					996:1006	cell composition	991:1006	cell composition	991:1006	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	4	14	theme	pyrin	695:699	arg1	domain					701:706	the NLR family pyrin domain	680:706	the NLR family pyrin domain containing 3 (NLRP3) inflammasome	680:740	To delineate the mechanism, the potential capacity of GOS to inhibit the NLR family pyrin domain containing 3 (NLRP3) inflammasome has been investigated.
35777914	5	15	theme	METHODS	765:771	arg1	GOS					773:775	METHODS GOS	765:775	METHODS GOS	765:775	METHODS GOS were administrated orally to calves with naturally occurring lung infections during early life or used as pretreatments in cell cultures exposed to M. haemolytica, lipopolysaccharides (LPS), leukotoxin or ATP.
35777914	5	15	theme	METHODS	765:771	arg1	pretreatments					883:895	pretreatments	883:895	pretreatments in cell cultures exposed to M. haemolytica	883:938	METHODS GOS were administrated orally to calves with naturally occurring lung infections during early life or used as pretreatments in cell cultures exposed to M. haemolytica, lipopolysaccharides (LPS), leukotoxin or ATP.
35777914	5	16	theme	cell	900:903	arg1	cultures					905:912	cell cultures	900:912	cell cultures exposed to M. haemolytica	900:938	METHODS GOS were administrated orally to calves with naturally occurring lung infections during early life or used as pretreatments in cell cultures exposed to M. haemolytica, lipopolysaccharides (LPS), leukotoxin or ATP.
35777914	12	17	from	activation	1915:1924	arg1	PBECs					1929:1933	PBECs	1929:1933	PBECs	1929:1933	The LPS- and ATP-induced NLRP3 inflammasome activation in PBECs and A549 cells was suppressed by GOS.
35777914	12	17	from	activation	1915:1924	arg1	cells					1944:1948	A549 cells	1939:1948	A549 cells	1939:1948	The LPS- and ATP-induced NLRP3 inflammasome activation in PBECs and A549 cells was suppressed by GOS.
35777914	13	18	from	role	2116:2119	arg1	prevention					2136:2145	the prevention	2132:2145	the prevention of lung infections	2132:2164	CONCLUSION GOS exert anti-inflammatory properties by inhibiting the NLRP3 inflammasome activation in vitro and in vivo, suggesting a potential role for GOS in the prevention of lung infections.
35777914	13	19	theme	lung	2150:2153	arg1	infections					2155:2164	lung infections	2150:2164	lung infections	2150:2164	CONCLUSION GOS exert anti-inflammatory properties by inhibiting the NLRP3 inflammasome activation in vitro and in vivo, suggesting a potential role for GOS in the prevention of lung infections.
35777914	2	20	theme	Non-digestible	253:266	arg1	GOS					294:296	GOS	294:296	GOS	294:296	Non-digestible galacto-oligosaccharides (GOS) are attractive candidates due to their anti-inflammatory and immunomodulatory effects both locally and systemically.
35777914	2	20	theme	Non-digestible	253:266	arg1	galacto-oligosaccharides					268:291	Non-digestible galacto-oligosaccharides	253:291	Non-digestible galacto-oligosaccharides (GOS)	253:297	Non-digestible galacto-oligosaccharides (GOS) are attractive candidates due to their anti-inflammatory and immunomodulatory effects both locally and systemically.
35777914	2	20	theme	Non-digestible	253:266	arg1	candidates					314:323	attractive candidates	303:323	attractive candidates due to their anti-inflammatory and immunomodulatory effects	303:383	Non-digestible galacto-oligosaccharides (GOS) are attractive candidates due to their anti-inflammatory and immunomodulatory effects both locally and systemically.
35777914	8	21	theme	M.	1335:1336	arg1	positivity					1350:1359	M. haemolytica positivity	1335:1359	M. haemolytica positivity	1335:1359	RESULTS GOS reduced M. haemolytica positivity and M. haemolytica-LPS lgG levels in calves with lung infections.
35777914	13	22	theme	CONCLUSION	1973:1982	arg1	GOS					1984:1986	CONCLUSION GOS	1973:1986	CONCLUSION GOS	1973:1986	CONCLUSION GOS exert anti-inflammatory properties by inhibiting the NLRP3 inflammasome activation in vitro and in vivo, suggesting a potential role for GOS in the prevention of lung infections.
35777914	2	23	theme	attractive	303:312	arg1	galacto-oligosaccharides					268:291	Non-digestible galacto-oligosaccharides	253:291	Non-digestible galacto-oligosaccharides (GOS)	253:297	Non-digestible galacto-oligosaccharides (GOS) are attractive candidates due to their anti-inflammatory and immunomodulatory effects both locally and systemically.
35777914	2	23	theme	attractive	303:312	arg1	candidates					314:323	attractive candidates	303:323	attractive candidates due to their anti-inflammatory and immunomodulatory effects	303:383	Non-digestible galacto-oligosaccharides (GOS) are attractive candidates due to their anti-inflammatory and immunomodulatory effects both locally and systemically.
35777914	9	24	theme	inflammasome	1543:1554	arg1	inhibition					1523:1532	the inhibition	1519:1532	the inhibition of NLRP3 inflammasome	1519:1554	Regulation of immune function and suppression of inflammatory response by GOS is related to the inhibition of NLRP3 inflammasome as observed in bronchial mucosal tissue of infected calves.
35777914	3	25	theme	epithelial	546:555	arg1	PBECs					564:568	PBECs	564:568	PBECs	564:568	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	3	25	theme	epithelial	546:555	arg1	cells					557:561	calf primary bronchial epithelial cells	523:561	calf primary bronchial epithelial cells (PBECs)	523:569	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	7	26	theme	activation	1268:1277	arg1	markers					1238:1244	Key markers	1234:1244	Key markers of NLRP3 inflammasome activation	1234:1277	Key markers of NLRP3 inflammasome activation were measured in vivo and in vitro.
35777914	1	27	theme	therapies	172:180	arg1	lack					136:139	The lack	132:139	INTRODUCTION The lack of effective anti-inflammatory therapies for pneumonia	119:194	INTRODUCTION The lack of effective anti-inflammatory therapies for pneumonia represents a challenge for identifying new alternatives.
35777914	6	28	theme	haemolytica-LPS	1051:1065	arg1	levels					1071:1076	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels	987:1076	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood	987:1126	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	8	29	theme	M.	1365:1366	arg1	levels					1388:1393	M. haemolytica-LPS lgG levels	1365:1393	M. haemolytica-LPS lgG levels	1365:1393	RESULTS GOS reduced M. haemolytica positivity and M. haemolytica-LPS lgG levels in calves with lung infections.
35777914	11	30	theme	leukotoxin-induced	1827:1844	arg1	production					1850:1859	leukotoxin-induced ATP production	1827:1859	leukotoxin-induced ATP production in PBECs	1827:1868	GOS inhibited leukotoxin-induced ATP production in PBECs.
35777914	7	31	theme	NLRP3	1249:1253	arg1	activation					1268:1277	NLRP3 inflammasome activation	1249:1277	NLRP3 inflammasome activation	1249:1277	Key markers of NLRP3 inflammasome activation were measured in vivo and in vitro.
35777914	9	32	theme	bronchial	1571:1579	arg1	tissue					1589:1594	bronchial mucosal tissue	1571:1594	bronchial mucosal tissue of infected calves	1571:1613	Regulation of immune function and suppression of inflammatory response by GOS is related to the inhibition of NLRP3 inflammasome as observed in bronchial mucosal tissue of infected calves.
35777914	3	33	theme	anti-inflammatory	431:447	arg1	properties					449:458	The anti-inflammatory properties	427:458	OBJECTIVES The anti-inflammatory properties of GOS	416:465	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	8	34	theme	lgG	1384:1386	arg1	levels					1388:1393	M. haemolytica-LPS lgG levels	1365:1393	M. haemolytica-LPS lgG levels	1365:1393	RESULTS GOS reduced M. haemolytica positivity and M. haemolytica-LPS lgG levels in calves with lung infections.
35777914	13	35	theme	potential	2106:2114	arg1	role					2116:2119	a potential role	2104:2119	a potential role for GOS in the prevention of lung infections	2104:2164	CONCLUSION GOS exert anti-inflammatory properties by inhibiting the NLRP3 inflammasome activation in vitro and in vivo, suggesting a potential role for GOS in the prevention of lung infections.
35777914	6	36	theme	concentrations	1028:1041	arg1	levels					1071:1076	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels	987:1076	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood	987:1126	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	9	37	theme	infected	1599:1606	arg1	calves					1608:1613	infected calves	1599:1613	infected calves	1599:1613	Regulation of immune function and suppression of inflammatory response by GOS is related to the inhibition of NLRP3 inflammasome as observed in bronchial mucosal tissue of infected calves.
35777914	1	38	theme	effective	144:152	arg1	therapies					172:180	effective anti-inflammatory therapies	144:180	effective anti-inflammatory therapies for pneumonia	144:194	INTRODUCTION The lack of effective anti-inflammatory therapies for pneumonia represents a challenge for identifying new alternatives.
35777914	10	39	theme	inflammasome	1721:1732	arg1	inhibition					1734:1743	NLRP3 inflammasome inhibition	1715:1743	NLRP3 inflammasome inhibition caused by the decreased reactive oxygen species and ATP production	1715:1810	The M. haemolytica-induced IL-1β production in PBECs was lowered by GOS, which was associated with NLRP3 inflammasome inhibition caused by the decreased reactive oxygen species and ATP production.
35777914	0	40	theme	lung	35:38	arg1	inflammation					40:51	lung inflammation	35:51	lung inflammation	35:51	Galacto-oligosaccharides alleviate lung inflammation by inhibiting NLRP3 inflammasome activation in vivo and in vitro.
35777914	3	41	theme	primary	528:534	arg1	PBECs					564:568	PBECs	564:568	PBECs	564:568	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	3	41	theme	primary	528:534	arg1	cells					557:561	calf primary bronchial epithelial cells	523:561	calf primary bronchial epithelial cells (PBECs)	523:569	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	5	42	theme	lung	838:841	arg1	infections					843:852	naturally occurring lung infections	818:852	naturally occurring lung infections	818:852	METHODS GOS were administrated orally to calves with naturally occurring lung infections during early life or used as pretreatments in cell cultures exposed to M. haemolytica, lipopolysaccharides (LPS), leukotoxin or ATP.
35777914	12	43	theme	A549	1939:1942	arg1	cells					1944:1948	A549 cells	1939:1948	A549 cells	1939:1948	The LPS- and ATP-induced NLRP3 inflammasome activation in PBECs and A549 cells was suppressed by GOS.
35777914	12	44	theme	LPS-	1875:1878	arg1	activation					1915:1924	The LPS- and ATP-induced NLRP3 inflammasome activation	1871:1924	The LPS- and ATP-induced NLRP3 inflammasome activation in PBECs and A549 cells	1871:1948	The LPS- and ATP-induced NLRP3 inflammasome activation in PBECs and A549 cells was suppressed by GOS.
35777914	6	45	theme	broncho-alveolar	1081:1096	arg1	lavage					1098:1103	broncho-alveolar lavage	1081:1103	broncho-alveolar lavage fluid (BALF)	1081:1116	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	3	46	dep	OBJECTIVES	416:425	arg1	properties					449:458	The anti-inflammatory properties	427:458	OBJECTIVES The anti-inflammatory properties of GOS	416:465	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	0	47	theme	NLRP3	67:71	arg1	activation					86:95	NLRP3 inflammasome activation	67:95	NLRP3 inflammasome activation	67:95	Galacto-oligosaccharides alleviate lung inflammation by inhibiting NLRP3 inflammasome activation in vivo and in vitro.
35777914	12	48	theme	NLRP3	1896:1900	arg1	activation					1915:1924	The LPS- and ATP-induced NLRP3 inflammasome activation	1871:1924	The LPS- and ATP-induced NLRP3 inflammasome activation in PBECs and A549 cells	1871:1948	The LPS- and ATP-induced NLRP3 inflammasome activation in PBECs and A549 cells was suppressed by GOS.
35777914	12	49	theme	ATP-induced	1884:1894	arg1	activation					1915:1924	The LPS- and ATP-induced NLRP3 inflammasome activation	1871:1924	The LPS- and ATP-induced NLRP3 inflammasome activation in PBECs and A549 cells	1871:1948	The LPS- and ATP-induced NLRP3 inflammasome activation in PBECs and A549 cells was suppressed by GOS.
35777914	6	50	dep	M.	1157:1158	arg1	haemolytica					1160:1170	haemolytica	1160:1170	haemolytica	1160:1170	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	1	51	dep	INTRODUCTION	119:130	arg1	lack					136:139	The lack	132:139	INTRODUCTION The lack of effective anti-inflammatory therapies for pneumonia	119:194	INTRODUCTION The lack of effective anti-inflammatory therapies for pneumonia represents a challenge for identifying new alternatives.
35777914	4	52	contain	containing	708:717	arg1	domain					701:706	the NLR family pyrin domain	680:706	the NLR family pyrin domain containing 3 (NLRP3) inflammasome	680:740	To delineate the mechanism, the potential capacity of GOS to inhibit the NLR family pyrin domain containing 3 (NLRP3) inflammasome has been investigated.
35777914	4	52	contain	containing	708:717	arg2	inflammasome					729:740	3 (NLRP3) inflammasome	719:740	3 (NLRP3) inflammasome	719:740	To delineate the mechanism, the potential capacity of GOS to inhibit the NLR family pyrin domain containing 3 (NLRP3) inflammasome has been investigated.
35777914	3	53	theme	epithelial	586:595	arg1	A549					604:607	A549	604:607	A549	604:607	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	3	53	theme	epithelial	586:595	arg1	cells					597:601	human lung epithelial cells	575:601	human lung epithelial cells (A549)	575:608	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	3	54	theme	human	575:579	arg1	A549					604:607	A549	604:607	A549	604:607	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	3	54	theme	human	575:579	arg1	cells					597:601	human lung epithelial cells	575:601	human lung epithelial cells (A549)	575:608	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	12	55	theme	inflammasome	1902:1913	arg1	activation					1915:1924	The LPS- and ATP-induced NLRP3 inflammasome activation	1871:1924	The LPS- and ATP-induced NLRP3 inflammasome activation in PBECs and A549 cells	1871:1948	The LPS- and ATP-induced NLRP3 inflammasome activation in PBECs and A549 cells was suppressed by GOS.
35777914	9	56	theme	function	1448:1455	arg1	Regulation					1427:1436	Regulation	1427:1436	Regulation of immune function and suppression of inflammatory response by GOS	1427:1503	Regulation of immune function and suppression of inflammatory response by GOS is related to the inhibition of NLRP3 inflammasome as observed in bronchial mucosal tissue of infected calves.
35777914	10	57	theme	M.	1620:1621	arg1	production					1649:1658	The M. haemolytica-induced IL-1β production	1616:1658	The M. haemolytica-induced IL-1β production in PBECs	1616:1667	The M. haemolytica-induced IL-1β production in PBECs was lowered by GOS, which was associated with NLRP3 inflammasome inhibition caused by the decreased reactive oxygen species and ATP production.
35777914	13	58	theme	NLRP3	2041:2045	arg1	activation					2060:2069	the NLRP3 inflammasome activation	2037:2069	the NLRP3 inflammasome activation	2037:2069	CONCLUSION GOS exert anti-inflammatory properties by inhibiting the NLRP3 inflammasome activation in vitro and in vivo, suggesting a potential role for GOS in the prevention of lung infections.
35777914	2	59	theme	anti-inflammatory	338:354	arg1	effects					377:383	their anti-inflammatory and immunomodulatory effects	332:383	their anti-inflammatory and immunomodulatory effects	332:383	Non-digestible galacto-oligosaccharides (GOS) are attractive candidates due to their anti-inflammatory and immunomodulatory effects both locally and systemically.
35777914	9	60	theme	suppression	1461:1471	arg1	Regulation					1427:1436	Regulation	1427:1436	Regulation of immune function and suppression of inflammatory response by GOS	1427:1503	Regulation of immune function and suppression of inflammatory response by GOS is related to the inhibition of NLRP3 inflammasome as observed in bronchial mucosal tissue of infected calves.
35777914	3	61	with	calves	488:493	arg1	infections					505:514	lung infections	500:514	lung infections	500:514	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	4	62	theme	potential	643:651	arg1	capacity					653:660	the potential capacity	639:660	the potential capacity of GOS to inhibit the NLR family pyrin domain containing 3 (NLRP3) inflammasome	639:740	To delineate the mechanism, the potential capacity of GOS to inhibit the NLR family pyrin domain containing 3 (NLRP3) inflammasome has been investigated.
35777914	10	63	theme	ATP	1797:1799	arg1	production					1801:1810	ATP production	1797:1810	ATP production	1797:1810	The M. haemolytica-induced IL-1β production in PBECs was lowered by GOS, which was associated with NLRP3 inflammasome inhibition caused by the decreased reactive oxygen species and ATP production.
35777914	9	64	theme	inflammatory	1476:1487	arg1	response					1489:1496	inflammatory response	1476:1496	inflammatory response	1476:1496	Regulation of immune function and suppression of inflammatory response by GOS is related to the inhibition of NLRP3 inflammasome as observed in bronchial mucosal tissue of infected calves.
35777914	6	65	theme	cytokine/chemokine	1009:1026	arg1	concentrations					1028:1041	cytokine/chemokine concentrations	1009:1041	cytokine/chemokine concentrations	1009:1041	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	10	66	theme	IL-1β	1643:1647	arg1	production					1649:1658	The M. haemolytica-induced IL-1β production	1616:1658	The M. haemolytica-induced IL-1β production in PBECs	1616:1667	The M. haemolytica-induced IL-1β production in PBECs was lowered by GOS, which was associated with NLRP3 inflammasome inhibition caused by the decreased reactive oxygen species and ATP production.
35777914	2	67	theme	immunomodulatory	360:375	arg1	effects					377:383	their anti-inflammatory and immunomodulatory effects	332:383	their anti-inflammatory and immunomodulatory effects	332:383	Non-digestible galacto-oligosaccharides (GOS) are attractive candidates due to their anti-inflammatory and immunomodulatory effects both locally and systemically.
35777914	6	68	theme	composition	996:1006	arg1	levels					1071:1076	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels	987:1076	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood	987:1126	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	4	69	theme	family	688:693	arg1	domain					701:706	the NLR family pyrin domain	680:706	the NLR family pyrin domain containing 3 (NLRP3) inflammasome	680:740	To delineate the mechanism, the potential capacity of GOS to inhibit the NLR family pyrin domain containing 3 (NLRP3) inflammasome has been investigated.
35777914	8	70	theme	RESULTS	1315:1321	arg1	GOS					1323:1325	RESULTS GOS	1315:1325	RESULTS GOS	1315:1325	RESULTS GOS reduced M. haemolytica positivity and M. haemolytica-LPS lgG levels in calves with lung infections.
35777914	13	71	theme	infections	2155:2164	arg1	prevention					2136:2145	the prevention	2132:2145	the prevention of lung infections	2132:2164	CONCLUSION GOS exert anti-inflammatory properties by inhibiting the NLRP3 inflammasome activation in vitro and in vivo, suggesting a potential role for GOS in the prevention of lung infections.
35777914	5	72	from	pretreatments	883:895	arg1	cultures					905:912	cell cultures	900:912	cell cultures exposed to M. haemolytica	900:938	METHODS GOS were administrated orally to calves with naturally occurring lung infections during early life or used as pretreatments in cell cultures exposed to M. haemolytica, lipopolysaccharides (LPS), leukotoxin or ATP.
35777914	9	73	theme	NLRP3	1537:1541	arg1	inflammasome					1543:1554	NLRP3 inflammasome	1537:1554	NLRP3 inflammasome	1537:1554	Regulation of immune function and suppression of inflammatory response by GOS is related to the inhibition of NLRP3 inflammasome as observed in bronchial mucosal tissue of infected calves.
35777914	7	74	theme	inflammasome	1255:1266	arg1	activation					1268:1277	NLRP3 inflammasome activation	1249:1277	NLRP3 inflammasome activation	1249:1277	Key markers of NLRP3 inflammasome activation were measured in vivo and in vitro.
35777914	1	75	theme	anti-inflammatory	154:170	arg1	therapies					172:180	effective anti-inflammatory therapies	144:180	effective anti-inflammatory therapies for pneumonia	144:194	INTRODUCTION The lack of effective anti-inflammatory therapies for pneumonia represents a challenge for identifying new alternatives.
35777914	6	76	theme	lgG	1067:1069	arg1	levels					1071:1076	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels	987:1076	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood	987:1126	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	5	77	with	calves	806:811	arg1	infections					843:852	naturally occurring lung infections	818:852	naturally occurring lung infections	818:852	METHODS GOS were administrated orally to calves with naturally occurring lung infections during early life or used as pretreatments in cell cultures exposed to M. haemolytica, lipopolysaccharides (LPS), leukotoxin or ATP.
35777914	4	78	theme	NLRP3	722:726	arg1	inflammasome					729:740	3 (NLRP3) inflammasome	719:740	3 (NLRP3) inflammasome	719:740	To delineate the mechanism, the potential capacity of GOS to inhibit the NLR family pyrin domain containing 3 (NLRP3) inflammasome has been investigated.
35777914	6	79	theme	M.	1048:1049	arg1	haemolytica-LPS					1051:1065	M. haemolytica-LPS	1048:1065	M. haemolytica-LPS	1048:1065	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	11	80	theme	ATP	1846:1848	arg1	production					1850:1859	leukotoxin-induced ATP production	1827:1859	leukotoxin-induced ATP production in PBECs	1827:1868	GOS inhibited leukotoxin-induced ATP production in PBECs.
35777914	7	81	theme	Key	1234:1236	arg1	markers					1238:1244	Key markers	1234:1244	Key markers of NLRP3 inflammasome activation	1234:1277	Key markers of NLRP3 inflammasome activation were measured in vivo and in vitro.
35777914	9	82	theme	mucosal	1581:1587	arg1	tissue					1589:1594	bronchial mucosal tissue	1571:1594	bronchial mucosal tissue of infected calves	1571:1613	Regulation of immune function and suppression of inflammatory response by GOS is related to the inhibition of NLRP3 inflammasome as observed in bronchial mucosal tissue of infected calves.
35777914	6	83	from	levels	1071:1076	arg1	fluid					1105:1109	broncho-alveolar lavage fluid	1081:1109	broncho-alveolar lavage fluid (BALF)	1081:1116	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	6	83	from	levels	1071:1076	arg1	BALF					1112:1115	BALF	1112:1115	BALF	1112:1115	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	6	83	from	levels	1071:1076	arg1	blood					1122:1126	blood	1122:1126	blood	1122:1126	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	8	84	theme	haemolytica-LPS	1368:1382	arg1	levels					1388:1393	M. haemolytica-LPS lgG levels	1365:1393	M. haemolytica-LPS lgG levels	1365:1393	RESULTS GOS reduced M. haemolytica positivity and M. haemolytica-LPS lgG levels in calves with lung infections.
35777914	8	85	with	calves	1398:1403	arg1	infections					1415:1424	lung infections	1410:1424	lung infections	1410:1424	RESULTS GOS reduced M. haemolytica positivity and M. haemolytica-LPS lgG levels in calves with lung infections.
35777914	3	86	theme	calf	523:526	arg1	PBECs					564:568	PBECs	564:568	PBECs	564:568	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	3	86	theme	calf	523:526	arg1	cells					557:561	calf primary bronchial epithelial cells	523:561	calf primary bronchial epithelial cells (PBECs)	523:569	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	5	87	theme	early	861:865	arg1	life					867:870	early life	861:870	early life	861:870	METHODS GOS were administrated orally to calves with naturally occurring lung infections during early life or used as pretreatments in cell cultures exposed to M. haemolytica, lipopolysaccharides (LPS), leukotoxin or ATP.
35777914	9	88	theme	calves	1608:1613	arg1	tissue					1589:1594	bronchial mucosal tissue	1571:1594	bronchial mucosal tissue of infected calves	1571:1613	Regulation of immune function and suppression of inflammatory response by GOS is related to the inhibition of NLRP3 inflammasome as observed in bronchial mucosal tissue of infected calves.
35777914	3	89	theme	GOS	463:465	arg1	properties					449:458	The anti-inflammatory properties	427:458	OBJECTIVES The anti-inflammatory properties of GOS	416:465	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	8	90	theme	lung	1410:1413	arg1	infections					1415:1424	lung infections	1410:1424	lung infections	1410:1424	RESULTS GOS reduced M. haemolytica positivity and M. haemolytica-LPS lgG levels in calves with lung infections.
35777914	10	91	theme	NLRP3	1715:1719	arg1	inhibition					1734:1743	NLRP3 inflammasome inhibition	1715:1743	NLRP3 inflammasome inhibition caused by the decreased reactive oxygen species and ATP production	1715:1810	The M. haemolytica-induced IL-1β production in PBECs was lowered by GOS, which was associated with NLRP3 inflammasome inhibition caused by the decreased reactive oxygen species and ATP production.
35777914	5	92	theme	occurring	828:836	arg1	infections					843:852	naturally occurring lung infections	818:852	naturally occurring lung infections	818:852	METHODS GOS were administrated orally to calves with naturally occurring lung infections during early life or used as pretreatments in cell cultures exposed to M. haemolytica, lipopolysaccharides (LPS), leukotoxin or ATP.
35777914	6	93	theme	lavage	1098:1103	arg1	fluid					1105:1109	broncho-alveolar lavage fluid	1081:1109	broncho-alveolar lavage fluid (BALF)	1081:1116	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	6	93	theme	lavage	1098:1103	arg1	BALF					1112:1115	BALF	1112:1115	BALF	1112:1115	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	3	94	theme	lung	500:503	arg1	infections					505:514	lung infections	500:514	lung infections	500:514	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	3	95	theme	bronchial	536:544	arg1	PBECs					564:568	PBECs	564:568	PBECs	564:568	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	3	95	theme	bronchial	536:544	arg1	cells					557:561	calf primary bronchial epithelial cells	523:561	calf primary bronchial epithelial cells (PBECs)	523:569	OBJECTIVES The anti-inflammatory properties of GOS were investigated in calves with lung infections and in calf primary bronchial epithelial cells (PBECs) and human lung epithelial cells (A549).
35777914	0	96	theme	inflammasome	73:84	arg1	activation					86:95	NLRP3 inflammasome activation	67:95	NLRP3 inflammasome activation	67:95	Galacto-oligosaccharides alleviate lung inflammation by inhibiting NLRP3 inflammasome activation in vivo and in vitro.
35777914	5	97	used	used	875:878	arg2	GOS					773:775	METHODS GOS	765:775	METHODS GOS	765:775	METHODS GOS were administrated orally to calves with naturally occurring lung infections during early life or used as pretreatments in cell cultures exposed to M. haemolytica, lipopolysaccharides (LPS), leukotoxin or ATP.
35777914	5	97	used	used	875:878	arg2	pretreatments					883:895	pretreatments	883:895	pretreatments in cell cultures exposed to M. haemolytica	883:938	METHODS GOS were administrated orally to calves with naturally occurring lung infections during early life or used as pretreatments in cell cultures exposed to M. haemolytica, lipopolysaccharides (LPS), leukotoxin or ATP.
35777914	6	98	from	positivity	1172:1181	arg1	BALF					1186:1189	BALF	1186:1189	BALF	1186:1189	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	6	98	from	positivity	1172:1181	arg1	mucosa					1205:1210	bronchial mucosa	1195:1210	bronchial mucosa	1195:1210	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	8	99	dep	M.	1335:1336	arg1	haemolytica					1338:1348	haemolytica	1338:1348	haemolytica	1338:1348	RESULTS GOS reduced M. haemolytica positivity and M. haemolytica-LPS lgG levels in calves with lung infections.
35777914	6	100	theme	M.	1157:1158	arg1	positivity					1172:1181	the M. haemolytica positivity	1153:1181	the M. haemolytica positivity in BALF and bronchial mucosa	1153:1210	The cell composition, cytokine/chemokine concentrations, and M. haemolytica-LPS lgG levels in broncho-alveolar lavage fluid (BALF) and blood were investigated, while the M. haemolytica positivity in BALF and bronchial mucosa was detected in vivo.
35777914	4	101	theme	GOS	665:667	arg1	capacity					653:660	the potential capacity	639:660	the potential capacity of GOS to inhibit the NLR family pyrin domain containing 3 (NLRP3) inflammasome	639:740	To delineate the mechanism, the potential capacity of GOS to inhibit the NLR family pyrin domain containing 3 (NLRP3) inflammasome has been investigated.
35777914	10	102	theme	oxygen	1778:1783	arg1	species					1785:1791	the decreased reactive oxygen species	1755:1791	the decreased reactive oxygen species	1755:1791	The M. haemolytica-induced IL-1β production in PBECs was lowered by GOS, which was associated with NLRP3 inflammasome inhibition caused by the decreased reactive oxygen species and ATP production.
35777914	9	103	theme	immune	1441:1446	arg1	function					1448:1455	immune function	1441:1455	immune function	1441:1455	Regulation of immune function and suppression of inflammatory response by GOS is related to the inhibition of NLRP3 inflammasome as observed in bronchial mucosal tissue of infected calves.
34973773	0	0	theme	chitosan	86:93	arg1	film					95:98	transparent chitosan film	74:98	transparent chitosan film	74:98	Enhancing the thermostability, UV shielding and antimicrobial activity of transparent chitosan film by carbon quantum dots containing N/P.
34973773	6	1	theme	%	850:850	arg1	light					860:864	26.8% visible light	846:864	26.8% visible light	846:864	The film containing 4 wt% NP-CQDs blocked more than 90.2% UV-A and 96.5% UV-B; however, it only blocked 26.8% visible light.
34973773	8	2	theme	multifunctional	1016:1030	arg1	film					1041:1044	multifunctional bio-safe film	1016:1044	multifunctional bio-safe film	1016:1044	This work provided a feasible way to prepare multifunctional bio-safe film.
34973773	0	3	theme	transparent	74:84	arg1	film					95:98	transparent chitosan film	74:98	transparent chitosan film	74:98	Enhancing the thermostability, UV shielding and antimicrobial activity of transparent chitosan film by carbon quantum dots containing N/P.
34973773	6	4	theme	film	746:749	arg1	NP-CQDs					768:774	The film containing 4 wt% NP-CQDs	742:774	The film containing 4 wt% NP-CQDs	742:774	The film containing 4 wt% NP-CQDs blocked more than 90.2% UV-A and 96.5% UV-B; however, it only blocked 26.8% visible light.
34973773	4	5	theme	film	630:633	arg1	angle					614:618	the water contact angle	596:618	the water contact angle of the CS film	596:633	The introduction of 4 wt% NP-CQDs increased the water contact angle of the CS film from 79.2° to 105.8°.
34973773	1	6	theme	due	240:242	arg1	areas					234:238	food and medicine packaging areas	206:238	food and medicine packaging areas due to their biodegradability and good availability	206:290	The chitosan (CS) transparent film has attracted much attention in food and medicine packaging areas due to their biodegradability and good availability.
34973773	8	7	theme	bio-safe	1032:1039	arg1	film					1041:1044	multifunctional bio-safe film	1016:1044	multifunctional bio-safe film	1016:1044	This work provided a feasible way to prepare multifunctional bio-safe film.
34973773	2	8	contain	containing	330:339	arg1	compound					321:328	A novel carbon quantum dots compound	293:328	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs)	293:373	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs) was obtained by reacting citric acids, with urea and phytic acids.
34973773	2	8	contain	containing	330:339	arg2	NP-CQDs					366:372	NP-CQDs	366:372	NP-CQDs	366:372	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs) was obtained by reacting citric acids, with urea and phytic acids.
34973773	2	8	contain	containing	330:339	arg2	phosphorus					354:363	phosphorus	354:363	phosphorus	354:363	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs) was obtained by reacting citric acids, with urea and phytic acids.
34973773	2	8	contain	containing	330:339	arg2	nitrogen					341:348	nitrogen	341:348	nitrogen	341:348	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs) was obtained by reacting citric acids, with urea and phytic acids.
34973773	3	9	theme	vapor	495:499	arg1	permeation					501:510	the water vapor permeation	485:510	the water vapor permeation	485:510	The density of the film was increased, and the water vapor permeation was reduced by the presence of NP-CQDs.
34973773	0	10	theme	film	95:98	arg1	thermostability					14:28	thermostability	14:28	thermostability	14:28	Enhancing the thermostability, UV shielding and antimicrobial activity of transparent chitosan film by carbon quantum dots containing N/P.
34973773	0	10	theme	film	95:98	arg1	shielding					34:42	UV shielding	31:42	UV shielding	31:42	Enhancing the thermostability, UV shielding and antimicrobial activity of transparent chitosan film by carbon quantum dots containing N/P.
34973773	0	10	theme	film	95:98	arg1	activity					62:69	antimicrobial activity	48:69	antimicrobial activity	48:69	Enhancing the thermostability, UV shielding and antimicrobial activity of transparent chitosan film by carbon quantum dots containing N/P.
34973773	4	11	theme	%	576:576	arg1	NP-CQDs					578:584	4 wt% NP-CQDs	572:584	4 wt% NP-CQDs	572:584	The introduction of 4 wt% NP-CQDs increased the water contact angle of the CS film from 79.2° to 105.8°.
34973773	8	12	theme	feasible	992:999	arg1	way					1001:1003	a feasible way	990:1003	a feasible way to prepare multifunctional bio-safe film	990:1044	This work provided a feasible way to prepare multifunctional bio-safe film.
34973773	0	13	theme	quantum	110:116	arg1	dots					118:121	carbon quantum dots	103:121	carbon quantum dots containing N/P	103:136	Enhancing the thermostability, UV shielding and antimicrobial activity of transparent chitosan film by carbon quantum dots containing N/P.
34973773	2	14	theme	citric	400:405	arg1	acids					407:411	citric acids	400:411	citric acids	400:411	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs) was obtained by reacting citric acids, with urea and phytic acids.
34973773	4	15	theme	contact	606:612	arg1	angle					614:618	the water contact angle	596:618	the water contact angle of the CS film	596:633	The introduction of 4 wt% NP-CQDs increased the water contact angle of the CS film from 79.2° to 105.8°.
34973773	0	16	theme	carbon	103:108	arg1	dots					118:121	carbon quantum dots	103:121	carbon quantum dots containing N/P	103:136	Enhancing the thermostability, UV shielding and antimicrobial activity of transparent chitosan film by carbon quantum dots containing N/P.
34973773	2	17	with	acids	407:411	arg1	urea					419:422	urea	419:422	urea	419:422	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs) was obtained by reacting citric acids, with urea and phytic acids.
34973773	3	18	theme	water	489:493	arg1	permeation					501:510	the water vapor permeation	485:510	the water vapor permeation	485:510	The density of the film was increased, and the water vapor permeation was reduced by the presence of NP-CQDs.
34973773	1	19	theme	transparent	157:167	arg1	film					169:172	The chitosan (CS) transparent film	139:172	The chitosan (CS) transparent film	139:172	The chitosan (CS) transparent film has attracted much attention in food and medicine packaging areas due to their biodegradability and good availability.
34973773	7	20	theme	control	954:960	arg1	film					965:968	the control CS film	950:968	the control CS film	950:968	It also exhibited better antibacterial activity to both E. coli and S. aureus than the control CS film.
34973773	2	21	theme	carbon	301:306	arg1	dots					316:319	carbon quantum dots	301:319	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs)	293:373	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs) was obtained by reacting citric acids, with urea and phytic acids.
34973773	7	22	theme	CS	962:963	arg1	film					965:968	the control CS film	950:968	the control CS film	950:968	It also exhibited better antibacterial activity to both E. coli and S. aureus than the control CS film.
34973773	2	23	theme	novel	295:299	arg1	compound					321:328	A novel carbon quantum dots compound	293:328	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs)	293:373	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs) was obtained by reacting citric acids, with urea and phytic acids.
34973773	6	24	theme	visible	852:858	arg1	light					860:864	26.8% visible light	846:864	26.8% visible light	846:864	The film containing 4 wt% NP-CQDs blocked more than 90.2% UV-A and 96.5% UV-B; however, it only blocked 26.8% visible light.
34973773	4	25	theme	NP-CQDs	578:584	arg1	introduction					556:567	The introduction	552:567	The introduction of 4 wt% NP-CQDs	552:584	The introduction of 4 wt% NP-CQDs increased the water contact angle of the CS film from 79.2° to 105.8°.
34973773	4	26	dep	105.8°	649:654	arg1	to					646:647	to	646:647	to	646:647	The introduction of 4 wt% NP-CQDs increased the water contact angle of the CS film from 79.2° to 105.8°.
34973773	1	27	theme	good	274:277	arg1	availability					279:290	good availability	274:290	good availability	274:290	The chitosan (CS) transparent film has attracted much attention in food and medicine packaging areas due to their biodegradability and good availability.
34973773	1	28	theme	much	188:191	arg1	attention					193:201	much attention	188:201	much attention	188:201	The chitosan (CS) transparent film has attracted much attention in food and medicine packaging areas due to their biodegradability and good availability.
34973773	6	29	theme	26.8	846:849	arg1	%					850:850	%	850:850	%	850:850	The film containing 4 wt% NP-CQDs blocked more than 90.2% UV-A and 96.5% UV-B; however, it only blocked 26.8% visible light.
34973773	3	30	theme	NP-CQDs	543:549	arg1	presence					531:538	the presence	527:538	the presence of NP-CQDs	527:549	The density of the film was increased, and the water vapor permeation was reduced by the presence of NP-CQDs.
34973773	0	31	contain	containing	123:132	arg1	dots					118:121	carbon quantum dots	103:121	carbon quantum dots containing N/P	103:136	Enhancing the thermostability, UV shielding and antimicrobial activity of transparent chitosan film by carbon quantum dots containing N/P.
34973773	0	31	contain	containing	123:132	arg2	N/P					134:136	N/P	134:136	N/P	134:136	Enhancing the thermostability, UV shielding and antimicrobial activity of transparent chitosan film by carbon quantum dots containing N/P.
34973773	0	32	theme	UV	31:32	arg1	shielding					34:42	UV shielding	31:42	UV shielding	31:42	Enhancing the thermostability, UV shielding and antimicrobial activity of transparent chitosan film by carbon quantum dots containing N/P.
34973773	6	33	dep	%	813:813	arg1	UV-B					815:818	UV-B	815:818	96.5% UV-B	809:818	The film containing 4 wt% NP-CQDs blocked more than 90.2% UV-A and 96.5% UV-B; however, it only blocked 26.8% visible light.
34973773	4	34	theme	4 wt	572:575	arg1	NP-CQDs					578:584	4 wt% NP-CQDs	572:584	4 wt% NP-CQDs	572:584	The introduction of 4 wt% NP-CQDs increased the water contact angle of the CS film from 79.2° to 105.8°.
34973773	0	35	theme	antimicrobial	48:60	arg1	activity					62:69	antimicrobial activity	48:69	antimicrobial activity	48:69	Enhancing the thermostability, UV shielding and antimicrobial activity of transparent chitosan film by carbon quantum dots containing N/P.
34973773	5	36	theme	NP-CQDs	725:731	arg1	loading					733:739	the NP-CQDs loading	721:739	the NP-CQDs loading	721:739	The shielding on UV-A and UV-B transmittance was increased with the NP-CQDs loading.
34973773	5	37	from	shielding	661:669	arg1	UV-A					674:677	UV-A	674:677	UV-A	674:677	The shielding on UV-A and UV-B transmittance was increased with the NP-CQDs loading.
34973773	5	37	from	shielding	661:669	arg1	transmittance					688:700	UV-B transmittance	683:700	UV-B transmittance	683:700	The shielding on UV-A and UV-B transmittance was increased with the NP-CQDs loading.
34973773	2	38	theme	phytic	428:433	arg1	acids					435:439	phytic acids	428:439	phytic acids	428:439	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs) was obtained by reacting citric acids, with urea and phytic acids.
34973773	7	39	theme	better	885:890	arg1	activity					906:913	better antibacterial activity	885:913	better antibacterial activity	885:913	It also exhibited better antibacterial activity to both E. coli and S. aureus than the control CS film.
34973773	3	40	theme	film	461:464	arg1	density					446:452	The density	442:452	The density of the film	442:464	The density of the film was increased, and the water vapor permeation was reduced by the presence of NP-CQDs.
34973773	6	41	theme	%	766:766	arg1	NP-CQDs					768:774	The film containing 4 wt% NP-CQDs	742:774	The film containing 4 wt% NP-CQDs	742:774	The film containing 4 wt% NP-CQDs blocked more than 90.2% UV-A and 96.5% UV-B; however, it only blocked 26.8% visible light.
34973773	7	42	theme	antibacterial	892:904	arg1	activity					906:913	better antibacterial activity	885:913	better antibacterial activity	885:913	It also exhibited better antibacterial activity to both E. coli and S. aureus than the control CS film.
34973773	2	43	theme	dots	316:319	arg1	compound					321:328	A novel carbon quantum dots compound	293:328	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs)	293:373	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs) was obtained by reacting citric acids, with urea and phytic acids.
34973773	1	44	theme	food	206:209	arg1	areas					234:238	food and medicine packaging areas	206:238	food and medicine packaging areas due to their biodegradability and good availability	206:290	The chitosan (CS) transparent film has attracted much attention in food and medicine packaging areas due to their biodegradability and good availability.
34973773	6	45	theme	4 wt	762:765	arg1	NP-CQDs					768:774	The film containing 4 wt% NP-CQDs	742:774	The film containing 4 wt% NP-CQDs	742:774	The film containing 4 wt% NP-CQDs blocked more than 90.2% UV-A and 96.5% UV-B; however, it only blocked 26.8% visible light.
34973773	0	46	dep	thermostability	14:28	arg1	the					10:12	the	10:12	the	10:12	Enhancing the thermostability, UV shielding and antimicrobial activity of transparent chitosan film by carbon quantum dots containing N/P.
34973773	2	47	with	acids	435:439	arg1	urea					419:422	urea	419:422	urea	419:422	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs) was obtained by reacting citric acids, with urea and phytic acids.
34973773	2	48	theme	quantum	308:314	arg1	dots					316:319	carbon quantum dots	301:319	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs)	293:373	A novel carbon quantum dots compound containing nitrogen and phosphorus (NP-CQDs) was obtained by reacting citric acids, with urea and phytic acids.
34973773	6	49	dep	%	798:798	arg1	UV-A					800:803	UV-A	800:803	more than 90.2% UV-A	784:803	The film containing 4 wt% NP-CQDs blocked more than 90.2% UV-A and 96.5% UV-B; however, it only blocked 26.8% visible light.
34973773	6	50	theme	containing	751:760	arg1	NP-CQDs					768:774	The film containing 4 wt% NP-CQDs	742:774	The film containing 4 wt% NP-CQDs	742:774	The film containing 4 wt% NP-CQDs blocked more than 90.2% UV-A and 96.5% UV-B; however, it only blocked 26.8% visible light.
34973773	4	51	theme	CS	627:628	arg1	film					630:633	the CS film	623:633	the CS film	623:633	The introduction of 4 wt% NP-CQDs increased the water contact angle of the CS film from 79.2° to 105.8°.
34973773	4	52	theme	water	600:604	arg1	angle					614:618	the water contact angle	596:618	the water contact angle of the CS film	596:633	The introduction of 4 wt% NP-CQDs increased the water contact angle of the CS film from 79.2° to 105.8°.
34973773	1	53	theme	medicine	215:222	arg1	areas					234:238	food and medicine packaging areas	206:238	food and medicine packaging areas due to their biodegradability and good availability	206:290	The chitosan (CS) transparent film has attracted much attention in food and medicine packaging areas due to their biodegradability and good availability.
34973773	5	54	theme	UV-B	683:686	arg1	transmittance					688:700	UV-B transmittance	683:700	UV-B transmittance	683:700	The shielding on UV-A and UV-B transmittance was increased with the NP-CQDs loading.
34973773	1	55	theme	packaging	224:232	arg1	areas					234:238	food and medicine packaging areas	206:238	food and medicine packaging areas due to their biodegradability and good availability	206:290	The chitosan (CS) transparent film has attracted much attention in food and medicine packaging areas due to their biodegradability and good availability.
33641915	0	0	theme	rabbit	98:103	arg1	model					105:109	a small-caliber vascular prosthesis rabbit model	62:109	a small-caliber vascular prosthesis rabbit model	62:109	Implantation of air-dried bacterial nanocellulose conduits in a small-caliber vascular prosthesis rabbit model.
33641915	7	1	theme	white	1135:1139	arg1	rabbits					1141:1147	New Zealand white rabbits	1123:1147	New Zealand white rabbits	1123:1147	Forty-six days after replacement of the carotid artery in New Zealand white rabbits, the BNC-Dry conduits remained patent.
33641915	6	2	from	morphology	743:752	arg1	diameter					866:873	diameter	866:873	diameter	866:873	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	6	3	theme	conduits	1018:1025	arg1	hemocompatibility					966:982	hemocompatibility	966:982	hemocompatibility	966:982	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	6	3	theme	conduits	1018:1025	arg1	cytocompatibility					989:1005	cytocompatibility	989:1005	cytocompatibility	989:1005	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	6	3	theme	conduits	1018:1025	arg1	properties					954:963	the mechanical properties	939:963	the mechanical properties	939:963	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	6	3	theme	conduits	1018:1025	arg1	superior					1032:1039	superior	1032:1039	superior	1032:1039	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	0	4	theme	prosthesis	87:96	arg1	model					105:109	a small-caliber vascular prosthesis rabbit model	62:109	a small-caliber vascular prosthesis rabbit model	62:109	Implantation of air-dried bacterial nanocellulose conduits in a small-caliber vascular prosthesis rabbit model.
33641915	11	5	theme	small-diameter	1680:1693	arg1	vessels					1701:1707	small-diameter blood vessels	1680:1707	small-diameter blood vessels	1680:1707	BNC-Dry conduits exhibited excellent performance and possessed properties convenient for surgical applications as small-diameter blood vessels.
33641915	10	6	theme	outer	1485:1489	arg1	surface					1491:1497	the outer surface	1481:1497	the outer surface of the conduit, similar to that observed in natural blood vessels	1481:1563	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	3	7	theme	due	524:526	arg1	surgery					516:522	surgery	516:522	surgery due to their softness	516:544	Although BNC hydrogel-like (BNC-Gel) materials possess a 3D network structure, facilitating nutrient exchange when used as vascular prostheses, they are difficult to suture during surgery due to their softness.
33641915	6	8	theme	BNC-Dry	1010:1016	arg1	conduits					1018:1025	BNC-Dry conduits	1010:1025	BNC-Dry conduits	1010:1025	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	0	9	from	Implantation	0:11	arg1	model					105:109	a small-caliber vascular prosthesis rabbit model	62:109	a small-caliber vascular prosthesis rabbit model	62:109	Implantation of air-dried bacterial nanocellulose conduits in a small-caliber vascular prosthesis rabbit model.
33641915	5	10	theme	Air-drying	670:679	arg1	BNC-Dry					690:696	BNC-Dry	690:696	BNC-Dry	690:696	Air-drying the BNC (BNC-Dry) would solve these problems.
33641915	5	10	theme	Air-drying	670:679	arg1	BNC					685:687	Air-drying the BNC	670:687	Air-drying the BNC (BNC-Dry)	670:697	Air-drying the BNC (BNC-Dry) would solve these problems.
33641915	6	11	theme	BNC-Gel	826:832	arg1	conduits					846:853	the BNC-Gel and BNC-Dry conduits	822:853	the BNC-Gel and BNC-Dry conduits of 3 mm	822:861	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	2	12	theme	artificial	298:307	arg1	applications					322:333	small-caliber artificial blood vessel applications	284:333	small-caliber artificial blood vessel applications	284:333	Bacterial nanocellulose (BNC) is considered a promising material for small-caliber artificial blood vessel applications.
33641915	7	13	from	replacement	1086:1096	arg1	rabbits					1141:1147	New Zealand white rabbits	1123:1147	New Zealand white rabbits	1123:1147	Forty-six days after replacement of the carotid artery in New Zealand white rabbits, the BNC-Dry conduits remained patent.
33641915	10	14	theme	Contractile	1425:1435	arg1	cells					1451:1455	Contractile smooth muscle cells	1425:1455	Contractile smooth muscle cells (SMCs)	1425:1462	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	10	14	theme	Contractile	1425:1435	arg1	SMCs					1458:1461	SMCs	1458:1461	SMCs	1458:1461	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	9	15	theme	outer	1360:1364	arg1	walls					1366:1370	the outer walls	1356:1370	the outer walls of the conduits	1356:1386	Sections demonstrated that the outer walls of the conduits were wrapped with autologous tissue.
33641915	7	16	theme	Zealand	1127:1133	arg1	rabbits					1141:1147	New Zealand white rabbits	1123:1147	New Zealand white rabbits	1123:1147	Forty-six days after replacement of the carotid artery in New Zealand white rabbits, the BNC-Dry conduits remained patent.
33641915	7	17	theme	BNC-Dry	1154:1160	arg1	conduits					1162:1169	the BNC-Dry conduits	1150:1169	the BNC-Dry conduits	1150:1169	Forty-six days after replacement of the carotid artery in New Zealand white rabbits, the BNC-Dry conduits remained patent.
33641915	7	17	theme	BNC-Dry	1154:1160	arg1	days					1075:1078	Forty-six days	1065:1078	Forty-six days after replacement of the carotid artery in New Zealand white rabbits	1065:1147	Forty-six days after replacement of the carotid artery in New Zealand white rabbits, the BNC-Dry conduits remained patent.
33641915	2	18	theme	small-caliber	284:296	arg1	applications					322:333	small-caliber artificial blood vessel applications	284:333	small-caliber artificial blood vessel applications	284:333	Bacterial nanocellulose (BNC) is considered a promising material for small-caliber artificial blood vessel applications.
33641915	6	19	from	properties	766:775	arg1	diameter					866:873	diameter	866:873	diameter	866:873	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	3	20	theme	BNC-Gel	364:370	arg1	materials					373:381	BNC hydrogel-like (BNC-Gel) materials	345:381	BNC hydrogel-like (BNC-Gel) materials	345:381	Although BNC hydrogel-like (BNC-Gel) materials possess a 3D network structure, facilitating nutrient exchange when used as vascular prostheses, they are difficult to suture during surgery due to their softness.
33641915	4	21	dep	content	568:574	arg1	%					591:591	%	591:591	%	591:591	Furthermore, a water content greater than 99% prevents the material from convenient methods of preservation and transport.
33641915	7	22	theme	artery	1113:1118	arg1	replacement					1086:1096	replacement	1086:1096	replacement of the carotid artery in New Zealand white rabbits	1086:1147	Forty-six days after replacement of the carotid artery in New Zealand white rabbits, the BNC-Dry conduits remained patent.
33641915	10	23	theme	smooth	1437:1442	arg1	cells					1451:1455	Contractile smooth muscle cells	1425:1455	Contractile smooth muscle cells (SMCs)	1425:1462	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	10	23	theme	smooth	1437:1442	arg1	SMCs					1458:1461	SMCs	1458:1461	SMCs	1458:1461	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	9	24	theme	conduits	1379:1386	arg1	walls					1366:1370	the outer walls	1356:1370	the outer walls of the conduits	1356:1386	Sections demonstrated that the outer walls of the conduits were wrapped with autologous tissue.
33641915	3	25	theme	nutrient	428:435	arg1	exchange					437:444	nutrient exchange	428:444	nutrient exchange when used as vascular prostheses	428:477	Although BNC hydrogel-like (BNC-Gel) materials possess a 3D network structure, facilitating nutrient exchange when used as vascular prostheses, they are difficult to suture during surgery due to their softness.
33641915	3	26	theme	vascular	459:466	arg1	prostheses					468:477	vascular prostheses	459:477	vascular prostheses	459:477	Although BNC hydrogel-like (BNC-Gel) materials possess a 3D network structure, facilitating nutrient exchange when used as vascular prostheses, they are difficult to suture during surgery due to their softness.
33641915	3	27	theme	network	396:402	arg1	structure					404:412	a 3D network structure	391:412	a 3D network structure	391:412	Although BNC hydrogel-like (BNC-Gel) materials possess a 3D network structure, facilitating nutrient exchange when used as vascular prostheses, they are difficult to suture during surgery due to their softness.
33641915	3	28	theme	BNC	345:347	arg1	materials					373:381	BNC hydrogel-like (BNC-Gel) materials	345:381	BNC hydrogel-like (BNC-Gel) materials	345:381	Although BNC hydrogel-like (BNC-Gel) materials possess a 3D network structure, facilitating nutrient exchange when used as vascular prostheses, they are difficult to suture during surgery due to their softness.
33641915	3	29	theme	hydrogel-like	349:361	arg1	materials					373:381	BNC hydrogel-like (BNC-Gel) materials	345:381	BNC hydrogel-like (BNC-Gel) materials	345:381	Although BNC hydrogel-like (BNC-Gel) materials possess a 3D network structure, facilitating nutrient exchange when used as vascular prostheses, they are difficult to suture during surgery due to their softness.
33641915	6	30	theme	present	896:902	arg1	study					904:908	the present study	892:908	the present study	892:908	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	1	31	theme	available	187:195	arg1	prostheses					156:165	no small-caliber (<6 mm) vascular prostheses	122:165	no small-caliber (<6 mm) vascular prostheses so far commercially available around the globe	122:212	There are no small-caliber (<6 mm) vascular prostheses so far commercially available around the globe.
33641915	8	32	theme	blood	1198:1202	arg1	vessels					1204:1210	Composite blood vessels	1188:1210	Composite blood vessels composed of cellulose and autologous tissue	1188:1254	Composite blood vessels composed of cellulose and autologous tissue were harvested for immunohistochemistry and immunofluorescence staining.
33641915	4	33	theme	water	562:566	arg1	content					568:574	a water content	560:574	a water content greater than 99%	560:591	Furthermore, a water content greater than 99% prevents the material from convenient methods of preservation and transport.
33641915	7	34	theme	carotid	1105:1111	arg1	artery					1113:1118	the carotid artery	1101:1118	the carotid artery	1101:1118	Forty-six days after replacement of the carotid artery in New Zealand white rabbits, the BNC-Dry conduits remained patent.
33641915	11	35	theme	excellent	1593:1601	arg1	performance					1603:1613	excellent performance	1593:1613	excellent performance	1593:1613	BNC-Dry conduits exhibited excellent performance and possessed properties convenient for surgical applications as small-diameter blood vessels.
33641915	6	36	theme	3 mm	858:861	arg1	conduits					846:853	the BNC-Gel and BNC-Dry conduits	822:853	the BNC-Gel and BNC-Dry conduits of 3 mm	822:861	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	0	37	theme	bacterial	26:34	arg1	conduits					50:57	air-dried bacterial nanocellulose conduits	16:57	air-dried bacterial nanocellulose conduits	16:57	Implantation of air-dried bacterial nanocellulose conduits in a small-caliber vascular prosthesis rabbit model.
33641915	11	38	theme	BNC-Dry	1566:1572	arg1	conduits					1574:1581	BNC-Dry conduits	1566:1581	BNC-Dry conduits	1566:1581	BNC-Dry conduits exhibited excellent performance and possessed properties convenient for surgical applications as small-diameter blood vessels.
33641915	2	39	theme	vessel	315:320	arg1	applications					322:333	small-caliber artificial blood vessel applications	284:333	small-caliber artificial blood vessel applications	284:333	Bacterial nanocellulose (BNC) is considered a promising material for small-caliber artificial blood vessel applications.
33641915	8	40	theme	immunofluorescence	1300:1317	arg1	staining					1319:1326	immunofluorescence staining	1300:1326	immunofluorescence staining	1300:1326	Composite blood vessels composed of cellulose and autologous tissue were harvested for immunohistochemistry and immunofluorescence staining.
33641915	0	41	theme	air-dried	16:24	arg1	conduits					50:57	air-dried bacterial nanocellulose conduits	16:57	air-dried bacterial nanocellulose conduits	16:57	Implantation of air-dried bacterial nanocellulose conduits in a small-caliber vascular prosthesis rabbit model.
33641915	6	42	theme	mechanical	755:764	arg1	properties					766:775	mechanical properties	755:775	mechanical properties	755:775	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	2	43	theme	blood	309:313	arg1	applications					322:333	small-caliber artificial blood vessel applications	284:333	small-caliber artificial blood vessel applications	284:333	Bacterial nanocellulose (BNC) is considered a promising material for small-caliber artificial blood vessel applications.
33641915	6	44	from	hemocompatibility	778:794	arg1	diameter					866:873	diameter	866:873	diameter	866:873	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	0	45	theme	conduits	50:57	arg1	Implantation					0:11	Implantation	0:11	Implantation of air-dried bacterial nanocellulose conduits in a small-caliber vascular prosthesis rabbit model.	0:110	Implantation of air-dried bacterial nanocellulose conduits in a small-caliber vascular prosthesis rabbit model.
33641915	10	46	located	observed	1531:1538	arg2	that					1526:1529	that	1526:1529	that	1526:1529	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	10	46	located	observed	1531:1538	arg1	vessels					1557:1563	natural blood vessels	1543:1563	natural blood vessels	1543:1563	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	4	47	dep	%	591:591	arg1	99					589:590	99	589:590	99	589:590	Furthermore, a water content greater than 99% prevents the material from convenient methods of preservation and transport.
33641915	4	48	from	methods	631:637	arg1	material					606:613	the material	602:613	the material from convenient methods of preservation and transport	602:667	Furthermore, a water content greater than 99% prevents the material from convenient methods of preservation and transport.
33641915	6	49	theme	BNC-Gel	1056:1062	arg1	conduits					1044:1051	conduits	1044:1051	conduits of BNC-Gel	1044:1062	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	0	50	theme	nanocellulose	36:48	arg1	conduits					50:57	air-dried bacterial nanocellulose conduits	16:57	air-dried bacterial nanocellulose conduits	16:57	Implantation of air-dried bacterial nanocellulose conduits in a small-caliber vascular prosthesis rabbit model.
33641915	9	51	theme	autologous	1406:1415	arg1	tissue					1417:1422	autologous tissue	1406:1422	autologous tissue	1406:1422	Sections demonstrated that the outer walls of the conduits were wrapped with autologous tissue.
33641915	10	52	theme	similar	1515:1521	arg1	conduit					1506:1512	the conduit	1502:1512	the conduit	1502:1512	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	11	53	contain	possessed	1619:1627	arg1	conduits					1574:1581	BNC-Dry conduits	1566:1581	BNC-Dry conduits	1566:1581	BNC-Dry conduits exhibited excellent performance and possessed properties convenient for surgical applications as small-diameter blood vessels.
33641915	11	53	contain	possessed	1619:1627	arg2	properties					1629:1638	properties	1629:1638	properties convenient for surgical applications as small-diameter blood vessels	1629:1707	BNC-Dry conduits exhibited excellent performance and possessed properties convenient for surgical applications as small-diameter blood vessels.
33641915	4	54	theme	preservation	642:653	arg1	methods					631:637	convenient methods	620:637	convenient methods of preservation and transport	620:667	Furthermore, a water content greater than 99% prevents the material from convenient methods of preservation and transport.
33641915	6	55	theme	mechanical	943:952	arg1	superior					1032:1039	superior	1032:1039	superior	1032:1039	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	6	55	theme	mechanical	943:952	arg1	properties					954:963	the mechanical properties	939:963	the mechanical properties	939:963	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	11	56	theme	surgical	1655:1662	arg1	applications					1664:1675	surgical applications	1655:1675	surgical applications as small-diameter blood vessels	1655:1707	BNC-Dry conduits exhibited excellent performance and possessed properties convenient for surgical applications as small-diameter blood vessels.
33641915	10	57	theme	blood	1551:1555	arg1	vessels					1557:1563	natural blood vessels	1543:1563	natural blood vessels	1543:1563	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	8	58	theme	autologous	1238:1247	arg1	tissue					1249:1254	autologous tissue	1238:1254	autologous tissue	1238:1254	Composite blood vessels composed of cellulose and autologous tissue were harvested for immunohistochemistry and immunofluorescence staining.
33641915	7	59	theme	Forty-six	1065:1073	arg1	conduits					1162:1169	the BNC-Dry conduits	1150:1169	the BNC-Dry conduits	1150:1169	Forty-six days after replacement of the carotid artery in New Zealand white rabbits, the BNC-Dry conduits remained patent.
33641915	7	59	theme	Forty-six	1065:1073	arg1	days					1075:1078	Forty-six days	1065:1078	Forty-six days after replacement of the carotid artery in New Zealand white rabbits	1065:1147	Forty-six days after replacement of the carotid artery in New Zealand white rabbits, the BNC-Dry conduits remained patent.
33641915	2	60	theme	Bacterial	215:223	arg1	BNC					240:242	BNC	240:242	BNC	240:242	Bacterial nanocellulose (BNC) is considered a promising material for small-caliber artificial blood vessel applications.
33641915	2	60	theme	Bacterial	215:223	arg1	nanocellulose					225:237	Bacterial nanocellulose	215:237	Bacterial nanocellulose (BNC)	215:243	Bacterial nanocellulose (BNC) is considered a promising material for small-caliber artificial blood vessel applications.
33641915	10	61	theme	conduit	1506:1512	arg1	surface					1491:1497	the outer surface	1481:1497	the outer surface of the conduit, similar to that observed in natural blood vessels	1481:1563	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	3	62	contain	possess	383:389	arg2	structure					404:412	a 3D network structure	391:412	a 3D network structure	391:412	Although BNC hydrogel-like (BNC-Gel) materials possess a 3D network structure, facilitating nutrient exchange when used as vascular prostheses, they are difficult to suture during surgery due to their softness.
33641915	3	62	contain	possess	383:389	arg1	materials					373:381	BNC hydrogel-like (BNC-Gel) materials	345:381	BNC hydrogel-like (BNC-Gel) materials	345:381	Although BNC hydrogel-like (BNC-Gel) materials possess a 3D network structure, facilitating nutrient exchange when used as vascular prostheses, they are difficult to suture during surgery due to their softness.
33641915	1	63	theme	small-caliber	125:137	arg1	prostheses					156:165	no small-caliber (<6 mm) vascular prostheses	122:165	no small-caliber (<6 mm) vascular prostheses so far commercially available around the globe	122:212	There are no small-caliber (<6 mm) vascular prostheses so far commercially available around the globe.
33641915	11	64	theme	blood	1695:1699	arg1	vessels					1701:1707	small-diameter blood vessels	1680:1707	small-diameter blood vessels	1680:1707	BNC-Dry conduits exhibited excellent performance and possessed properties convenient for surgical applications as small-diameter blood vessels.
33641915	10	65	theme	natural	1543:1549	arg1	vessels					1557:1563	natural blood vessels	1543:1563	natural blood vessels	1543:1563	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	2	66	theme	promising	261:269	arg1	material					271:278	a promising material	259:278	a promising material for small-caliber artificial blood vessel applications	259:333	Bacterial nanocellulose (BNC) is considered a promising material for small-caliber artificial blood vessel applications.
33641915	11	67	theme	convenient	1640:1649	arg1	properties					1629:1638	properties	1629:1638	properties convenient for surgical applications as small-diameter blood vessels	1629:1707	BNC-Dry conduits exhibited excellent performance and possessed properties convenient for surgical applications as small-diameter blood vessels.
33641915	6	68	theme	conduits	846:853	arg1	hemocompatibility					778:794	hemocompatibility	778:794	hemocompatibility	778:794	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	6	68	theme	conduits	846:853	arg1	morphology					743:752	The comparative morphology	727:752	The comparative morphology	727:752	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	6	68	theme	conduits	846:853	arg1	properties					766:775	mechanical properties	755:775	mechanical properties	755:775	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	6	68	theme	conduits	846:853	arg1	cytocompatibility					801:817	cytocompatibility	801:817	cytocompatibility	801:817	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	7	69	theme	New	1123:1125	arg1	rabbits					1141:1147	New Zealand white rabbits	1123:1147	New Zealand white rabbits	1123:1147	Forty-six days after replacement of the carotid artery in New Zealand white rabbits, the BNC-Dry conduits remained patent.
33641915	1	70	theme	<6 mm	140:144	arg1	prostheses					156:165	no small-caliber (<6 mm) vascular prostheses	122:165	no small-caliber (<6 mm) vascular prostheses so far commercially available around the globe	122:212	There are no small-caliber (<6 mm) vascular prostheses so far commercially available around the globe.
33641915	10	71	located	observed	1469:1476	arg1	surface					1491:1497	the outer surface	1481:1497	the outer surface of the conduit, similar to that observed in natural blood vessels	1481:1563	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	10	71	located	observed	1469:1476	arg2	SMCs					1458:1461	SMCs	1458:1461	SMCs	1458:1461	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	10	71	located	observed	1469:1476	arg2	cells					1451:1455	Contractile smooth muscle cells	1425:1455	Contractile smooth muscle cells (SMCs)	1425:1462	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	0	72	theme	vascular	78:85	arg1	model					105:109	a small-caliber vascular prosthesis rabbit model	62:109	a small-caliber vascular prosthesis rabbit model	62:109	Implantation of air-dried bacterial nanocellulose conduits in a small-caliber vascular prosthesis rabbit model.
33641915	6	73	theme	BNC-Dry	838:844	arg1	conduits					846:853	the BNC-Gel and BNC-Dry conduits	822:853	the BNC-Gel and BNC-Dry conduits of 3 mm	822:861	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	6	74	theme	comparative	731:741	arg1	morphology					743:752	The comparative morphology	727:752	The comparative morphology	727:752	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	10	75	theme	muscle	1444:1449	arg1	cells					1451:1455	Contractile smooth muscle cells	1425:1455	Contractile smooth muscle cells (SMCs)	1425:1462	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	10	75	theme	muscle	1444:1449	arg1	SMCs					1458:1461	SMCs	1458:1461	SMCs	1458:1461	Contractile smooth muscle cells (SMCs) were observed on the outer surface of the conduit, similar to that observed in natural blood vessels.
33641915	4	76	theme	transport	659:667	arg1	methods					631:637	convenient methods	620:637	convenient methods of preservation and transport	620:667	Furthermore, a water content greater than 99% prevents the material from convenient methods of preservation and transport.
33641915	4	77	theme	convenient	620:629	arg1	methods					631:637	convenient methods	620:637	convenient methods of preservation and transport	620:667	Furthermore, a water content greater than 99% prevents the material from convenient methods of preservation and transport.
33641915	0	78	theme	small-caliber	64:76	arg1	model					105:109	a small-caliber vascular prosthesis rabbit model	62:109	a small-caliber vascular prosthesis rabbit model	62:109	Implantation of air-dried bacterial nanocellulose conduits in a small-caliber vascular prosthesis rabbit model.
33641915	8	79	theme	Composite	1188:1196	arg1	vessels					1204:1210	Composite blood vessels	1188:1210	Composite blood vessels composed of cellulose and autologous tissue	1188:1254	Composite blood vessels composed of cellulose and autologous tissue were harvested for immunohistochemistry and immunofluorescence staining.
33641915	3	80	theme	3D	393:394	arg1	structure					404:412	a 3D network structure	391:412	a 3D network structure	391:412	Although BNC hydrogel-like (BNC-Gel) materials possess a 3D network structure, facilitating nutrient exchange when used as vascular prostheses, they are difficult to suture during surgery due to their softness.
33641915	6	81	from	cytocompatibility	801:817	arg1	diameter					866:873	diameter	866:873	diameter	866:873	The comparative morphology, mechanical properties, hemocompatibility, and cytocompatibility of the BNC-Gel and BNC-Dry conduits of 3 mm in diameter were recorded in the present study, the results indicating that the mechanical properties, hemocompatibility, and cytocompatibility of BNC-Dry conduits were superior to conduits of BNC-Gel.
33641915	1	82	theme	vascular	147:154	arg1	prostheses					156:165	no small-caliber (<6 mm) vascular prostheses	122:165	no small-caliber (<6 mm) vascular prostheses so far commercially available around the globe	122:212	There are no small-caliber (<6 mm) vascular prostheses so far commercially available around the globe.
32657258	0	0	from	evaluation	8:17	arg1	model					61:65	a rabbit model	52:65	a rabbit model for using as a dural substitute	52:97	In vivo evaluation of bilayer ORC/PCL composites in a rabbit model for using as a dural substitute.
32657258	3	1	dep	effectiveness	547:559	arg1	the					543:545	the	543:545	the	543:545	This study aimed to assess the effectiveness and safety of new bilayer ORC/PCL composites in a rabbit model.
32657258	1	2	theme	inflammatory	296:307	arg1	reactions					309:317	chronic inflammatory reactions	288:317	chronic inflammatory reactions	288:317	OBJECTIVE After a neurosurgical procedure, dural closure is commonly needed to prevent cerebrospinal fluids (CSF) leakage and to reduce the risk of complications, including infections and chronic inflammatory reactions.
32657258	4	3	theme	male	845:848	arg1	rabbits					850:856	forty-five male rabbits	834:856	forty-five male rabbits	834:856	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	5	4	theme	local	885:889	arg1	reaction					891:898	the local reaction	881:898	the local reaction of the samples	881:913	Systemic reaction and the local reaction of the samples were assessed and compared at one-, three- and six-months post-implantation by blood chemistry and gross, and microscopic assessment using hematoxylin-eosin and Masson's trichrome stains.
32657258	5	5	theme	six-months	962:971	arg1	post-implantation					973:989	six-months post-implantation	962:989	six-months post-implantation	962:989	Systemic reaction and the local reaction of the samples were assessed and compared at one-, three- and six-months post-implantation by blood chemistry and gross, and microscopic assessment using hematoxylin-eosin and Masson's trichrome stains.
32657258	5	6	theme	blood	994:998	arg1	chemistry					1000:1008	blood chemistry	994:1008	blood chemistry	994:1008	Systemic reaction and the local reaction of the samples were assessed and compared at one-, three- and six-months post-implantation by blood chemistry and gross, and microscopic assessment using hematoxylin-eosin and Masson's trichrome stains.
32657258	0	7	dep	dural	82:86	arg1	substitute					88:97	substitute	88:97	substitute	88:97	In vivo evaluation of bilayer ORC/PCL composites in a rabbit model for using as a dural substitute.
32657258	8	8	theme	autologous	1352:1361	arg1	group					1363:1367	the autologous group	1348:1367	the autologous group	1348:1367	The degree of host fibrous connective tissue ingrowth into both composites was comparable to that of the autologous group, but bone formation and osteoclast activities were significantly greater.
32657258	7	9	theme	adjacent	1229:1236	arg1	tissues					1238:1244	adjacent tissues	1229:1244	adjacent tissues	1229:1244	All samples demonstrated minimal adhesion to adjacent tissues.
32657258	4	10	theme	fabric-reinforced	732:748	arg1	composites					750:759	fabric-reinforced composites	732:759	fabric-reinforced composites	732:759	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	5	11	theme	samples	907:913	arg1	reaction					868:875	Systemic reaction	859:875	Systemic reaction	859:875	Systemic reaction and the local reaction of the samples were assessed and compared at one-, three- and six-months post-implantation by blood chemistry and gross, and microscopic assessment using hematoxylin-eosin and Masson's trichrome stains.
32657258	5	11	theme	samples	907:913	arg1	reaction					891:898	the local reaction	881:898	the local reaction of the samples	881:913	Systemic reaction and the local reaction of the samples were assessed and compared at one-, three- and six-months post-implantation by blood chemistry and gross, and microscopic assessment using hematoxylin-eosin and Masson's trichrome stains.
32657258	2	12	theme	postoperative	487:499	arg1	complications					501:513	postoperative complications	487:513	postoperative complications	487:513	Although several dural substitutes have been developed, their manufacturing processes are complicated and costly and that many of them have been implicated in causing postoperative complications.
32657258	5	13	theme	trichrome	1085:1093	arg1	stains					1095:1100	Masson's trichrome stains	1076:1100	Masson's trichrome stains	1076:1100	Systemic reaction and the local reaction of the samples were assessed and compared at one-, three- and six-months post-implantation by blood chemistry and gross, and microscopic assessment using hematoxylin-eosin and Masson's trichrome stains.
32657258	2	14	dep	and	422:424	arg1	costly					426:431	costly	426:431	costly	426:431	Although several dural substitutes have been developed, their manufacturing processes are complicated and costly and that many of them have been implicated in causing postoperative complications.
32657258	1	15	theme	dural	143:147	arg1	closure					149:155	dural closure	143:155	dural closure	143:155	OBJECTIVE After a neurosurgical procedure, dural closure is commonly needed to prevent cerebrospinal fluids (CSF) leakage and to reduce the risk of complications, including infections and chronic inflammatory reactions.
32657258	10	16	theme	DISCUSSION	1609:1618	arg1	composites					1636:1645	DISCUSSION Bilayer ORC/PCL composites	1609:1645	DISCUSSION Bilayer ORC/PCL composites	1609:1645	DISCUSSION Bilayer ORC/PCL composites were successfully employed for dural closure in the rabbit model.
32657258	4	17	from	closure	823:829	arg1	rabbits					850:856	forty-five male rabbits	834:856	forty-five male rabbits	834:856	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	0	18	theme	ORC/PCL	30:36	arg1	composites					38:47	bilayer ORC/PCL composites	22:47	bilayer ORC/PCL composites	22:47	In vivo evaluation of bilayer ORC/PCL composites in a rabbit model for using as a dural substitute.
32657258	2	19	dep	dural	337:341	arg1	substitutes					343:353	substitutes	343:353	substitutes	343:353	Although several dural substitutes have been developed, their manufacturing processes are complicated and costly and that many of them have been implicated in causing postoperative complications.
32657258	8	20	theme	bone	1374:1377	arg1	formation					1379:1387	bone formation	1374:1387	bone formation	1374:1387	The degree of host fibrous connective tissue ingrowth into both composites was comparable to that of the autologous group, but bone formation and osteoclast activities were significantly greater.
32657258	9	21	theme	nonporous	1527:1535	arg1	layer					1537:1541	the nonporous layer	1523:1541	the nonporous layer	1523:1541	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	8	22	theme	osteoclast	1393:1402	arg1	activities					1404:1413	osteoclast activities	1393:1413	osteoclast activities	1393:1413	The degree of host fibrous connective tissue ingrowth into both composites was comparable to that of the autologous group, but bone formation and osteoclast activities were significantly greater.
32657258	7	23	theme	minimal	1209:1215	arg1	adhesion					1217:1224	minimal adhesion	1209:1224	minimal adhesion to adjacent tissues	1209:1244	All samples demonstrated minimal adhesion to adjacent tissues.
32657258	6	24	theme	systemic	1138:1145	arg1	infection					1147:1155	systemic infection	1138:1155	systemic infection	1138:1155	RESULTS No signs of CSF leakage or systemic infection were seen for all samples.
32657258	4	25	theme	bilayer	653:659	arg1	formulations					637:648	Two formulations	633:648	Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL)	633:722	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	0	26	theme	In	0:1	arg1	evaluation					8:17	In vivo evaluation	0:17	In vivo evaluation of bilayer ORC/PCL composites in a rabbit model for using as a dural substitute.	0:98	In vivo evaluation of bilayer ORC/PCL composites in a rabbit model for using as a dural substitute.
32657258	10	27	theme	rabbit	1699:1704	arg1	model					1706:1710	the rabbit model	1695:1710	the rabbit model	1695:1710	DISCUSSION Bilayer ORC/PCL composites were successfully employed for dural closure in the rabbit model.
32657258	9	28	theme	initial	1558:1564	arg1	thickness					1566:1574	the initial thickness	1554:1574	the initial thickness	1554:1574	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	5	29	theme	Systemic	859:866	arg1	reaction					868:875	Systemic reaction	859:875	Systemic reaction	859:875	Systemic reaction and the local reaction of the samples were assessed and compared at one-, three- and six-months post-implantation by blood chemistry and gross, and microscopic assessment using hematoxylin-eosin and Masson's trichrome stains.
32657258	8	30	theme	tissue	1285:1290	arg1	ingrowth					1292:1299	host fibrous connective tissue ingrowth	1261:1299	host fibrous connective tissue ingrowth into both composites	1261:1320	The degree of host fibrous connective tissue ingrowth into both composites was comparable to that of the autologous group, but bone formation and osteoclast activities were significantly greater.
32657258	5	31	theme	gross	1014:1018	arg1	assessment					1037:1046	gross, and microscopic assessment	1014:1046	gross, and microscopic assessment using hematoxylin-eosin and Masson's trichrome stains	1014:1100	Systemic reaction and the local reaction of the samples were assessed and compared at one-, three- and six-months post-implantation by blood chemistry and gross, and microscopic assessment using hematoxylin-eosin and Masson's trichrome stains.
32657258	6	32	theme	leakage	1127:1133	arg1	signs					1114:1118	No signs	1111:1118	RESULTS No signs of CSF leakage or systemic infection	1103:1155	RESULTS No signs of CSF leakage or systemic infection were seen for all samples.
32657258	4	33	dep	METHODS	625:631	arg1	knitted					724:730	knitted	724:730	knitted fabric-reinforced composites and an autologous graft (pericranium)	724:797	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	11	34	theme	comparable	1774:1783	arg1	regeneration					1761:1772	dural regeneration	1755:1772	dural regeneration comparable to that of the autologous group	1755:1815	They were biocompatible and could support dural regeneration comparable to that of the autologous group, but induced greater osteogenesis.
32657258	11	35	theme	autologous	1800:1809	arg1	group					1811:1815	the autologous group	1796:1815	the autologous group	1796:1815	They were biocompatible and could support dural regeneration comparable to that of the autologous group, but induced greater osteogenesis.
32657258	6	36	theme	CSF	1123:1125	arg1	leakage					1127:1133	CSF leakage	1123:1133	CSF leakage	1123:1133	RESULTS No signs of CSF leakage or systemic infection were seen for all samples.
32657258	9	37	theme	layer	1537:1541	arg1	%					1549:1549	50%	1547:1549	50% of the initial thickness	1547:1574	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	9	37	theme	layer	1537:1541	arg1	thickness					1510:1518	the residual thickness	1497:1518	the residual thickness of the nonporous layer	1497:1541	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	9	37	theme	layer	1537:1541	arg1	thickness					1566:1574	the initial thickness	1554:1574	the initial thickness	1554:1574	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	2	38	theme	them	450:453	arg1	many					442:445	many	442:445	many	442:445	Although several dural substitutes have been developed, their manufacturing processes are complicated and costly and that many of them have been implicated in causing postoperative complications.
32657258	2	38	theme	them	450:453	arg1	them					450:453	them	450:453	them	450:453	Although several dural substitutes have been developed, their manufacturing processes are complicated and costly and that many of them have been implicated in causing postoperative complications.
32657258	1	39	theme	complications	248:260	arg1	risk					240:243	the risk	236:243	the risk of complications, including infections and chronic inflammatory reactions	236:317	OBJECTIVE After a neurosurgical procedure, dural closure is commonly needed to prevent cerebrospinal fluids (CSF) leakage and to reduce the risk of complications, including infections and chronic inflammatory reactions.
32657258	8	40	theme	host	1261:1264	arg1	ingrowth					1292:1299	host fibrous connective tissue ingrowth	1261:1299	host fibrous connective tissue ingrowth into both composites	1261:1320	The degree of host fibrous connective tissue ingrowth into both composites was comparable to that of the autologous group, but bone formation and osteoclast activities were significantly greater.
32657258	3	41	theme	new	575:577	arg1	composites					595:604	new bilayer ORC/PCL composites	575:604	new bilayer ORC/PCL composites	575:604	This study aimed to assess the effectiveness and safety of new bilayer ORC/PCL composites in a rabbit model.
32657258	9	42	from	months	1583:1588	arg1	%					1549:1549	50%	1547:1549	50% of the initial thickness	1547:1574	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	9	42	from	months	1583:1588	arg1	thickness					1510:1518	the residual thickness	1497:1518	the residual thickness of the nonporous layer	1497:1541	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	9	42	from	months	1583:1588	arg1	thickness					1566:1574	the initial thickness	1554:1574	the initial thickness	1554:1574	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	2	43	theme	manufacturing	382:394	arg1	processes					396:404	their manufacturing processes	376:404	their manufacturing processes	376:404	Although several dural substitutes have been developed, their manufacturing processes are complicated and costly and that many of them have been implicated in causing postoperative complications.
32657258	0	44	theme	bilayer	22:28	arg1	composites					38:47	bilayer ORC/PCL composites	22:47	bilayer ORC/PCL composites	22:47	In vivo evaluation of bilayer ORC/PCL composites in a rabbit model for using as a dural substitute.
32657258	10	45	theme	ORC/PCL	1628:1634	arg1	composites					1636:1645	DISCUSSION Bilayer ORC/PCL composites	1609:1645	DISCUSSION Bilayer ORC/PCL composites	1609:1645	DISCUSSION Bilayer ORC/PCL composites were successfully employed for dural closure in the rabbit model.
32657258	3	46	theme	rabbit	611:616	arg1	model					618:622	a rabbit model	609:622	a rabbit model	609:622	This study aimed to assess the effectiveness and safety of new bilayer ORC/PCL composites in a rabbit model.
32657258	3	47	theme	bilayer	579:585	arg1	composites					595:604	new bilayer ORC/PCL composites	575:604	new bilayer ORC/PCL composites	575:604	This study aimed to assess the effectiveness and safety of new bilayer ORC/PCL composites in a rabbit model.
32657258	6	48	dep	RESULTS	1103:1109	arg1	signs					1114:1118	No signs	1111:1118	RESULTS No signs of CSF leakage or systemic infection	1103:1155	RESULTS No signs of CSF leakage or systemic infection were seen for all samples.
32657258	1	49	theme	cerebrospinal	187:199	arg1	CSF					209:211	CSF	209:211	CSF	209:211	OBJECTIVE After a neurosurgical procedure, dural closure is commonly needed to prevent cerebrospinal fluids (CSF) leakage and to reduce the risk of complications, including infections and chronic inflammatory reactions.
32657258	1	49	theme	cerebrospinal	187:199	arg1	fluids					201:206	cerebrospinal fluids	187:206	cerebrospinal fluids (CSF) leakage	187:220	OBJECTIVE After a neurosurgical procedure, dural closure is commonly needed to prevent cerebrospinal fluids (CSF) leakage and to reduce the risk of complications, including infections and chronic inflammatory reactions.
32657258	10	50	theme	Bilayer	1620:1626	arg1	composites					1636:1645	DISCUSSION Bilayer ORC/PCL composites	1609:1645	DISCUSSION Bilayer ORC/PCL composites	1609:1645	DISCUSSION Bilayer ORC/PCL composites were successfully employed for dural closure in the rabbit model.
32657258	9	51	dep	months	1583:1588	arg1	post-implantation					1590:1606	post-implantation	1590:1606	six months post-implantation	1579:1606	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	8	52	theme	connective	1274:1283	arg1	ingrowth					1292:1299	host fibrous connective tissue ingrowth	1261:1299	host fibrous connective tissue ingrowth into both composites	1261:1320	The degree of host fibrous connective tissue ingrowth into both composites was comparable to that of the autologous group, but bone formation and osteoclast activities were significantly greater.
32657258	0	53	theme	composites	38:47	arg1	evaluation					8:17	In vivo evaluation	0:17	In vivo evaluation of bilayer ORC/PCL composites in a rabbit model for using as a dural substitute.	0:98	In vivo evaluation of bilayer ORC/PCL composites in a rabbit model for using as a dural substitute.
32657258	4	54	theme	dural	817:821	arg1	closure					823:829	dural closure	817:829	dural closure in forty-five male rabbits	817:856	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	2	55	dep	complicated	410:420	arg1	implicated					465:474	implicated	465:474	have been implicated in causing postoperative complications	455:513	Although several dural substitutes have been developed, their manufacturing processes are complicated and costly and that many of them have been implicated in causing postoperative complications.
32657258	2	55	dep	complicated	410:420	arg1	and					422:424	and	422:424	and	422:424	Although several dural substitutes have been developed, their manufacturing processes are complicated and costly and that many of them have been implicated in causing postoperative complications.
32657258	8	56	theme	fibrous	1266:1272	arg1	ingrowth					1292:1299	host fibrous connective tissue ingrowth	1261:1299	host fibrous connective tissue ingrowth into both composites	1261:1320	The degree of host fibrous connective tissue ingrowth into both composites was comparable to that of the autologous group, but bone formation and osteoclast activities were significantly greater.
32657258	3	57	theme	composites	595:604	arg1	safety					565:570	safety	565:570	safety	565:570	This study aimed to assess the effectiveness and safety of new bilayer ORC/PCL composites in a rabbit model.
32657258	3	57	theme	composites	595:604	arg1	effectiveness					547:559	effectiveness	547:559	effectiveness	547:559	This study aimed to assess the effectiveness and safety of new bilayer ORC/PCL composites in a rabbit model.
32657258	4	58	dep	bilayer	653:659	arg1	cellulose					682:690	oxidized regenerated cellulose	661:690	bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL)	653:722	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	4	58	dep	bilayer	653:659	arg1	PCL					719:721	PCL	719:721	PCL	719:721	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	4	58	dep	bilayer	653:659	arg1	ORC					693:695	ORC	693:695	ORC	693:695	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	4	58	dep	bilayer	653:659	arg1	ε-caprolactone					703:716	ε-caprolactone	703:716	bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL)	653:722	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	8	59	theme	ingrowth	1292:1299	arg1	degree					1251:1256	The degree	1247:1256	The degree of host fibrous connective tissue ingrowth into both composites	1247:1320	The degree of host fibrous connective tissue ingrowth into both composites was comparable to that of the autologous group, but bone formation and osteoclast activities were significantly greater.
32657258	8	59	theme	ingrowth	1292:1299	arg1	comparable					1326:1335	comparable	1326:1335	comparable	1326:1335	The degree of host fibrous connective tissue ingrowth into both composites was comparable to that of the autologous group, but bone formation and osteoclast activities were significantly greater.
32657258	9	60	theme	thickness	1566:1574	arg1	%					1549:1549	50%	1547:1549	50% of the initial thickness	1547:1574	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	9	60	theme	thickness	1566:1574	arg1	thickness					1510:1518	the residual thickness	1497:1518	the residual thickness of the nonporous layer	1497:1541	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	9	60	theme	thickness	1566:1574	arg1	thickness					1566:1574	the initial thickness	1554:1574	the initial thickness	1554:1574	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	1	61	theme	fluids	201:206	arg1	leakage					214:220	cerebrospinal fluids (CSF) leakage	187:220	cerebrospinal fluids (CSF) leakage	187:220	OBJECTIVE After a neurosurgical procedure, dural closure is commonly needed to prevent cerebrospinal fluids (CSF) leakage and to reduce the risk of complications, including infections and chronic inflammatory reactions.
32657258	6	62	theme	infection	1147:1155	arg1	signs					1114:1118	No signs	1111:1118	RESULTS No signs of CSF leakage or systemic infection	1103:1155	RESULTS No signs of CSF leakage or systemic infection were seen for all samples.
32657258	5	63	theme	microscopic	1025:1035	arg1	assessment					1037:1046	gross, and microscopic assessment	1014:1046	gross, and microscopic assessment using hematoxylin-eosin and Masson's trichrome stains	1014:1100	Systemic reaction and the local reaction of the samples were assessed and compared at one-, three- and six-months post-implantation by blood chemistry and gross, and microscopic assessment using hematoxylin-eosin and Masson's trichrome stains.
32657258	4	64	theme	autologous	768:777	arg1	pericranium					786:796	pericranium	786:796	pericranium	786:796	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	4	64	theme	autologous	768:777	arg1	graft					779:783	an autologous graft	765:783	an autologous graft (pericranium)	765:797	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	10	65	from	closure	1684:1690	arg1	model					1706:1710	the rabbit model	1695:1710	the rabbit model	1695:1710	DISCUSSION Bilayer ORC/PCL composites were successfully employed for dural closure in the rabbit model.
32657258	4	66	theme	oxidized	661:668	arg1	cellulose					682:690	oxidized regenerated cellulose	661:690	bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL)	653:722	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	4	66	theme	oxidized	661:668	arg1	ORC					693:695	ORC	693:695	ORC	693:695	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	9	67	theme	residual	1501:1508	arg1	%					1549:1549	50%	1547:1549	50% of the initial thickness	1547:1574	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	9	67	theme	residual	1501:1508	arg1	thickness					1510:1518	the residual thickness	1497:1518	the residual thickness of the nonporous layer	1497:1541	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	9	67	theme	residual	1501:1508	arg1	thickness					1566:1574	the initial thickness	1554:1574	the initial thickness	1554:1574	Both composites progressively degraded over times and the residual thickness of the nonporous layer was 50% of the initial thickness at six months post-implantation.
32657258	0	68	theme	rabbit	54:59	arg1	model					61:65	a rabbit model	52:65	a rabbit model for using as a dural substitute	52:97	In vivo evaluation of bilayer ORC/PCL composites in a rabbit model for using as a dural substitute.
32657258	10	69	theme	dural	1678:1682	arg1	closure					1684:1690	dural closure	1678:1690	dural closure in the rabbit model	1678:1710	DISCUSSION Bilayer ORC/PCL composites were successfully employed for dural closure in the rabbit model.
32657258	3	70	theme	ORC/PCL	587:593	arg1	composites					595:604	new bilayer ORC/PCL composites	575:604	new bilayer ORC/PCL composites	575:604	This study aimed to assess the effectiveness and safety of new bilayer ORC/PCL composites in a rabbit model.
32657258	4	71	theme	regenerated	670:680	arg1	cellulose					682:690	oxidized regenerated cellulose	661:690	bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL)	653:722	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	4	71	theme	regenerated	670:680	arg1	ORC					693:695	ORC	693:695	ORC	693:695	METHODS Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits.
32657258	11	72	theme	greater	1830:1836	arg1	osteogenesis					1838:1849	greater osteogenesis	1830:1849	greater osteogenesis	1830:1849	They were biocompatible and could support dural regeneration comparable to that of the autologous group, but induced greater osteogenesis.
32657258	1	73	theme	chronic	288:294	arg1	reactions					309:317	chronic inflammatory reactions	288:317	chronic inflammatory reactions	288:317	OBJECTIVE After a neurosurgical procedure, dural closure is commonly needed to prevent cerebrospinal fluids (CSF) leakage and to reduce the risk of complications, including infections and chronic inflammatory reactions.
32657258	0	74	dep	In	0:1	arg1	vivo					3:6	vivo	3:6	vivo	3:6	In vivo evaluation of bilayer ORC/PCL composites in a rabbit model for using as a dural substitute.
32657258	1	75	theme	neurosurgical	118:130	arg1	procedure					132:140	a neurosurgical procedure	116:140	a neurosurgical procedure	116:140	OBJECTIVE After a neurosurgical procedure, dural closure is commonly needed to prevent cerebrospinal fluids (CSF) leakage and to reduce the risk of complications, including infections and chronic inflammatory reactions.
32657258	11	76	theme	dural	1755:1759	arg1	regeneration					1761:1772	dural regeneration	1755:1772	dural regeneration comparable to that of the autologous group	1755:1815	They were biocompatible and could support dural regeneration comparable to that of the autologous group, but induced greater osteogenesis.
33264922	0	0	theme	volatile	97:104	arg1	compounds					114:122	volatile organic compounds	97:122	volatile organic compounds	97:122	Gelatin/β-Cyclodextrin Bio-Nanofibers as respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance.
33264922	5	1	theme	basis	732:736	arg1	g/m²					748:751	1 g/m²	746:751	1 g/m²	746:751	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	5	1	theme	basis	732:736	arg1	weight					738:743	low basis weight	728:743	low basis weight (1 g/m²)	728:752	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	5	2	theme	nanofiber	632:640	arg1	mats					642:645	gelatin/β-cyclodextrin composite nanofiber mats	599:645	gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²)	599:752	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	3	3	contain	has	337:339	arg2	issues					350:355	disposal issues	341:355	disposal issues	341:355	Synthetic polymer-based air filter media not only has disposal issues but also is a source of air and water pollution at the end of their life cycle.
33264922	3	3	contain	has	337:339	arg1	media					322:326	Synthetic polymer-based air filter media	287:326	Synthetic polymer-based air filter media	287:326	Synthetic polymer-based air filter media not only has disposal issues but also is a source of air and water pollution at the end of their life cycle.
33264922	5	4	theme	function	657:664	arg1	ability					681:687	dual function air filtration ability	652:687	dual function air filtration ability	652:687	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	3	5	theme	Synthetic	287:295	arg1	media					322:326	Synthetic polymer-based air filter media	287:326	Synthetic polymer-based air filter media	287:326	Synthetic polymer-based air filter media not only has disposal issues but also is a source of air and water pollution at the end of their life cycle.
33264922	4	6	theme	particulate	476:486	arg1	matter					488:493	particulate matter	476:493	particulate matter	476:493	It has been a challenge to filter both particulate matter and VOC pollutants by a common biodegradable filter media having low air resistance.
33264922	1	7	theme	universal	166:174	arg1	concern					176:182	a universal concern	164:182	a universal concern	164:182	Air pollution is a universal concern.
33264922	1	7	theme	universal	166:174	arg1	pollution					151:159	Air pollution	147:159	Air pollution	147:159	Air pollution is a universal concern.
33264922	10	8	contain	have	1266:1269	arg2	potential					1275:1283	the potential to filter nano-sized viruses	1271:1312	the potential to filter nano-sized viruses	1271:1312	Gelatin/β-cyclodextrin nanofibers also have the potential to filter nano-sized viruses.
33264922	10	8	contain	have	1266:1269	arg1	nanofibers					1250:1259	Gelatin/β-cyclodextrin nanofibers	1227:1259	Gelatin/β-cyclodextrin nanofibers	1227:1259	Gelatin/β-cyclodextrin nanofibers also have the potential to filter nano-sized viruses.
33264922	4	9	theme	filter	540:545	arg1	media					547:551	a common biodegradable filter media	517:551	a common biodegradable filter media having low air resistance	517:577	It has been a challenge to filter both particulate matter and VOC pollutants by a common biodegradable filter media having low air resistance.
33264922	0	10	theme	compounds	114:122	arg1	filtration					70:79	filtration	70:79	filtration of aerosols and volatile organic compounds at low air resistance	70:144	Gelatin/β-Cyclodextrin Bio-Nanofibers as respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance.
33264922	6	11	theme	0.029/Pa	854:861	arg1	factor					871:876	0.029/Pa quality factor	854:876	0.029/Pa quality factor	854:876	Gelatin/β-cyclodextrin nanofibers captured aerosols (0.3-5 μm) with < 95% filtration efficiency at 0.029/Pa quality factor.
33264922	4	12	theme	low	560:562	arg1	resistance					568:577	low air resistance	560:577	low air resistance	560:577	It has been a challenge to filter both particulate matter and VOC pollutants by a common biodegradable filter media having low air resistance.
33264922	0	13	theme	organic	106:112	arg1	compounds					114:122	volatile organic compounds	97:122	volatile organic compounds	97:122	Gelatin/β-Cyclodextrin Bio-Nanofibers as respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance.
33264922	5	14	theme	reduced	692:698	arg1	Pa					720:721	148 Pa	716:721	148 Pa	716:721	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	5	14	theme	reduced	692:698	arg1	resistance					704:713	reduced air resistance	692:713	reduced air resistance (148 Pa)	692:722	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	5	15	theme	dual	652:655	arg1	ability					681:687	dual function air filtration ability	652:687	dual function air filtration ability	652:687	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	6	16	theme	Gelatin/β-cyclodextrin	755:776	arg1	nanofibers					778:787	Gelatin/β-cyclodextrin nanofibers	755:787	Gelatin/β-cyclodextrin nanofibers	755:787	Gelatin/β-cyclodextrin nanofibers captured aerosols (0.3-5 μm) with < 95% filtration efficiency at 0.029/Pa quality factor.
33264922	8	17	theme	several	1044:1050	arg1	times					1052:1056	several times	1044:1056	several times higher than a commercial face mask and pristine powder samples	1044:1119	VOC adsorption of gelatin/β-cyclodextrin nanofibers is found several times higher than a commercial face mask and pristine powder samples.
33264922	0	18	theme	low	127:129	arg1	resistance					135:144	low air resistance	127:144	low air resistance	127:144	Gelatin/β-Cyclodextrin Bio-Nanofibers as respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance.
33264922	9	19	theme	low	1211:1213	arg1	resistance					1215:1224	low resistance	1211:1224	low resistance	1211:1224	This study provides a solution for a 'green' dual function respiratory air filtration at low resistance.
33264922	7	20	theme	xylene	909:914	arg1	VOCs					977:980	xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs	909:980	xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs	909:980	They adsorbed great amount of xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs.
33264922	8	21	theme	nanofibers	1024:1033	arg1	adsorption					987:996	VOC adsorption	983:996	VOC adsorption of gelatin/β-cyclodextrin nanofibers	983:1033	VOC adsorption of gelatin/β-cyclodextrin nanofibers is found several times higher than a commercial face mask and pristine powder samples.
33264922	8	22	theme	face	1083:1086	arg1	mask					1088:1091	a commercial face mask	1070:1091	a commercial face mask	1070:1091	VOC adsorption of gelatin/β-cyclodextrin nanofibers is found several times higher than a commercial face mask and pristine powder samples.
33264922	6	23	theme	filtration	829:838	arg1	efficiency					840:849	< 95% filtration efficiency	823:849	< 95% filtration efficiency	823:849	Gelatin/β-cyclodextrin nanofibers captured aerosols (0.3-5 μm) with < 95% filtration efficiency at 0.029/Pa quality factor.
33264922	9	24	theme	dual	1167:1170	arg1	filtration					1197:1206	a 'green' dual function respiratory air filtration	1157:1206	a 'green' dual function respiratory air filtration at low resistance	1157:1224	This study provides a solution for a 'green' dual function respiratory air filtration at low resistance.
33264922	7	25	theme	VOCs	977:980	arg1	amount					899:904	great amount	893:904	great amount of xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs	893:980	They adsorbed great amount of xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs.
33264922	7	25	theme	VOCs	977:980	arg1	VOCs					977:980	xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs	909:980	xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs	909:980	They adsorbed great amount of xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs.
33264922	0	26	theme	Gelatin/β-Cyclodextrin	0:21	arg1	Bio-Nanofibers					23:36	Gelatin/β-Cyclodextrin Bio-Nanofibers	0:36	Gelatin/β-Cyclodextrin Bio-Nanofibers as respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance.	0:145	Gelatin/β-Cyclodextrin Bio-Nanofibers as respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance.
33264922	8	27	theme	pristine	1097:1104	arg1	samples					1113:1119	pristine powder samples	1097:1119	pristine powder samples	1097:1119	VOC adsorption of gelatin/β-cyclodextrin nanofibers is found several times higher than a commercial face mask and pristine powder samples.
33264922	8	28	theme	higher	1058:1063	arg1	times					1052:1056	several times	1044:1056	several times higher than a commercial face mask and pristine powder samples	1044:1119	VOC adsorption of gelatin/β-cyclodextrin nanofibers is found several times higher than a commercial face mask and pristine powder samples.
33264922	5	29	theme	gelatin/β-cyclodextrin	599:620	arg1	mats					642:645	gelatin/β-cyclodextrin composite nanofiber mats	599:645	gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²)	599:752	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	8	30	theme	gelatin/β-cyclodextrin	1001:1022	arg1	nanofibers					1024:1033	gelatin/β-cyclodextrin nanofibers	1001:1033	gelatin/β-cyclodextrin nanofibers	1001:1033	VOC adsorption of gelatin/β-cyclodextrin nanofibers is found several times higher than a commercial face mask and pristine powder samples.
33264922	3	31	theme	air	381:383	arg1	pollution					395:403	air and water pollution	381:403	pollution	395:403	Synthetic polymer-based air filter media not only has disposal issues but also is a source of air and water pollution at the end of their life cycle.
33264922	5	32	theme	composite	622:630	arg1	mats					642:645	gelatin/β-cyclodextrin composite nanofiber mats	599:645	gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²)	599:752	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	0	33	theme	respiratory	41:51	arg1	media					60:64	respiratory filter media	41:64	respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance	41:144	Gelatin/β-Cyclodextrin Bio-Nanofibers as respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance.
33264922	8	34	theme	VOC	983:985	arg1	adsorption					987:996	VOC adsorption	983:996	VOC adsorption of gelatin/β-cyclodextrin nanofibers	983:1033	VOC adsorption of gelatin/β-cyclodextrin nanofibers is found several times higher than a commercial face mask and pristine powder samples.
33264922	10	35	theme	nano-sized	1295:1304	arg1	viruses					1306:1312	nano-sized viruses	1295:1312	nano-sized viruses	1295:1312	Gelatin/β-cyclodextrin nanofibers also have the potential to filter nano-sized viruses.
33264922	4	36	contain	having	553:558	arg2	resistance					568:577	low air resistance	560:577	low air resistance	560:577	It has been a challenge to filter both particulate matter and VOC pollutants by a common biodegradable filter media having low air resistance.
33264922	4	36	contain	having	553:558	arg1	media					547:551	a common biodegradable filter media	517:551	a common biodegradable filter media having low air resistance	517:577	It has been a challenge to filter both particulate matter and VOC pollutants by a common biodegradable filter media having low air resistance.
33264922	7	37	theme	benzene	928:934	arg1	VOCs					977:980	xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs	909:980	xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs	909:980	They adsorbed great amount of xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs.
33264922	4	38	theme	biodegradable	526:538	arg1	media					547:551	a common biodegradable filter media	517:551	a common biodegradable filter media having low air resistance	517:577	It has been a challenge to filter both particulate matter and VOC pollutants by a common biodegradable filter media having low air resistance.
33264922	0	39	theme	air	131:133	arg1	resistance					135:144	low air resistance	127:144	low air resistance	127:144	Gelatin/β-Cyclodextrin Bio-Nanofibers as respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance.
33264922	2	40	theme	suspended	189:197	arg1	particles					212:220	The suspended solid/liquid particles	185:220	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs)	185:269	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs) are ubiquitous.
33264922	2	40	theme	suspended	189:197	arg1	ubiquitous					275:284	ubiquitous	275:284	ubiquitous	275:284	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs) are ubiquitous.
33264922	5	41	with	mats	642:645	arg1	ability					681:687	dual function air filtration ability	652:687	dual function air filtration ability	652:687	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	2	42	dep	air	229:231	arg1	the					225:227	the	225:227	the	225:227	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs) are ubiquitous.
33264922	3	43	theme	pollution	395:403	arg1	source					371:376	a source	369:376	a source of air and water pollution	369:403	Synthetic polymer-based air filter media not only has disposal issues but also is a source of air and water pollution at the end of their life cycle.
33264922	4	44	theme	common	519:524	arg1	media					547:551	a common biodegradable filter media	517:551	a common biodegradable filter media having low air resistance	517:577	It has been a challenge to filter both particulate matter and VOC pollutants by a common biodegradable filter media having low air resistance.
33264922	5	45	theme	air	700:702	arg1	Pa					720:721	148 Pa	716:721	148 Pa	716:721	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	5	45	theme	air	700:702	arg1	resistance					704:713	reduced air resistance	692:713	reduced air resistance (148 Pa)	692:722	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	2	46	theme	organic	246:252	arg1	VOCs					265:268	VOCs	265:268	VOCs	265:268	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs) are ubiquitous.
33264922	2	46	theme	organic	246:252	arg1	compounds					254:262	volatile organic compounds	237:262	volatile organic compounds (VOCs)	237:269	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs) are ubiquitous.
33264922	6	47	dep	%	827:827	arg1	95					825:826	95	825:826	95	825:826	Gelatin/β-cyclodextrin nanofibers captured aerosols (0.3-5 μm) with < 95% filtration efficiency at 0.029/Pa quality factor.
33264922	3	48	theme	life	425:428	arg1	cycle					430:434	their life cycle	419:434	their life cycle	419:434	Synthetic polymer-based air filter media not only has disposal issues but also is a source of air and water pollution at the end of their life cycle.
33264922	0	49	theme	filter	53:58	arg1	media					60:64	respiratory filter media	41:64	respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance	41:144	Gelatin/β-Cyclodextrin Bio-Nanofibers as respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance.
33264922	5	50	from	resistance	704:713	arg1	mats					642:645	gelatin/β-cyclodextrin composite nanofiber mats	599:645	gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²)	599:752	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	2	51	theme	volatile	237:244	arg1	VOCs					265:268	VOCs	265:268	VOCs	265:268	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs) are ubiquitous.
33264922	2	51	theme	volatile	237:244	arg1	compounds					254:262	volatile organic compounds	237:262	volatile organic compounds (VOCs)	237:269	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs) are ubiquitous.
33264922	3	52	theme	cycle	430:434	arg1	end					412:414	the end	408:414	the end of their life cycle	408:434	Synthetic polymer-based air filter media not only has disposal issues but also is a source of air and water pollution at the end of their life cycle.
33264922	2	53	from	particles	212:220	arg1	air					229:231	air	229:231	air	229:231	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs) are ubiquitous.
33264922	2	53	from	particles	212:220	arg1	VOCs					265:268	VOCs	265:268	VOCs	265:268	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs) are ubiquitous.
33264922	2	53	from	particles	212:220	arg1	compounds					254:262	volatile organic compounds	237:262	volatile organic compounds (VOCs)	237:269	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs) are ubiquitous.
33264922	3	54	theme	filter	315:320	arg1	media					322:326	Synthetic polymer-based air filter media	287:326	Synthetic polymer-based air filter media	287:326	Synthetic polymer-based air filter media not only has disposal issues but also is a source of air and water pollution at the end of their life cycle.
33264922	5	55	theme	low	728:730	arg1	g/m²					748:751	1 g/m²	746:751	1 g/m²	746:751	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	5	55	theme	low	728:730	arg1	weight					738:743	low basis weight	728:743	low basis weight (1 g/m²)	728:752	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	5	56	theme	filtration	670:679	arg1	ability					681:687	dual function air filtration ability	652:687	dual function air filtration ability	652:687	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	3	57	theme	water	389:393	arg1	pollution					395:403	air and water pollution	381:403	pollution	395:403	Synthetic polymer-based air filter media not only has disposal issues but also is a source of air and water pollution at the end of their life cycle.
33264922	5	58	theme	air	666:668	arg1	ability					681:687	dual function air filtration ability	652:687	dual function air filtration ability	652:687	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	6	59	theme	quality	863:869	arg1	factor					871:876	0.029/Pa quality factor	854:876	0.029/Pa quality factor	854:876	Gelatin/β-cyclodextrin nanofibers captured aerosols (0.3-5 μm) with < 95% filtration efficiency at 0.029/Pa quality factor.
33264922	7	60	theme	great	893:897	arg1	amount					899:904	great amount	893:904	great amount of xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs	893:980	They adsorbed great amount of xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs.
33264922	7	60	theme	great	893:897	arg1	VOCs					977:980	xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs	909:980	xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs	909:980	They adsorbed great amount of xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs.
33264922	9	61	theme	respiratory	1181:1191	arg1	filtration					1197:1206	a 'green' dual function respiratory air filtration	1157:1206	a 'green' dual function respiratory air filtration at low resistance	1157:1224	This study provides a solution for a 'green' dual function respiratory air filtration at low resistance.
33264922	4	62	theme	VOC	499:501	arg1	pollutants					503:512	VOC pollutants	499:512	VOC pollutants	499:512	It has been a challenge to filter both particulate matter and VOC pollutants by a common biodegradable filter media having low air resistance.
33264922	3	63	theme	polymer-based	297:309	arg1	media					322:326	Synthetic polymer-based air filter media	287:326	Synthetic polymer-based air filter media	287:326	Synthetic polymer-based air filter media not only has disposal issues but also is a source of air and water pollution at the end of their life cycle.
33264922	5	64	from	weight	738:743	arg1	mats					642:645	gelatin/β-cyclodextrin composite nanofiber mats	599:645	gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²)	599:752	This study reports gelatin/β-cyclodextrin composite nanofiber mats with dual function air filtration ability at reduced air resistance (148 Pa) and low basis weight (1 g/m²).
33264922	10	65	theme	Gelatin/β-cyclodextrin	1227:1248	arg1	nanofibers					1250:1259	Gelatin/β-cyclodextrin nanofibers	1227:1259	Gelatin/β-cyclodextrin nanofibers	1227:1259	Gelatin/β-cyclodextrin nanofibers also have the potential to filter nano-sized viruses.
33264922	8	66	theme	commercial	1072:1081	arg1	mask					1088:1091	a commercial face mask	1070:1091	a commercial face mask	1070:1091	VOC adsorption of gelatin/β-cyclodextrin nanofibers is found several times higher than a commercial face mask and pristine powder samples.
33264922	3	67	theme	air	311:313	arg1	media					322:326	Synthetic polymer-based air filter media	287:326	Synthetic polymer-based air filter media	287:326	Synthetic polymer-based air filter media not only has disposal issues but also is a source of air and water pollution at the end of their life cycle.
33264922	1	68	theme	Air	147:149	arg1	concern					176:182	a universal concern	164:182	a universal concern	164:182	Air pollution is a universal concern.
33264922	1	68	theme	Air	147:149	arg1	pollution					151:159	Air pollution	147:159	Air pollution	147:159	Air pollution is a universal concern.
33264922	4	69	theme	air	564:566	arg1	resistance					568:577	low air resistance	560:577	low air resistance	560:577	It has been a challenge to filter both particulate matter and VOC pollutants by a common biodegradable filter media having low air resistance.
33264922	0	70	theme	aerosols	84:91	arg1	filtration					70:79	filtration	70:79	filtration of aerosols and volatile organic compounds at low air resistance	70:144	Gelatin/β-Cyclodextrin Bio-Nanofibers as respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance.
33264922	2	71	theme	solid/liquid	199:210	arg1	particles					212:220	The suspended solid/liquid particles	185:220	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs)	185:269	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs) are ubiquitous.
33264922	2	71	theme	solid/liquid	199:210	arg1	ubiquitous					275:284	ubiquitous	275:284	ubiquitous	275:284	The suspended solid/liquid particles in the air and volatile organic compounds (VOCs) are ubiquitous.
33264922	7	72	theme	formaldehyde	952:963	arg1	VOCs					977:980	xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs	909:980	xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs	909:980	They adsorbed great amount of xylene (287 mg/g), benzene (242 mg/g), and formaldehyde (0.75 mg/g) VOCs.
33264922	3	73	from	end	412:414	arg1	source					371:376	a source	369:376	a source of air and water pollution	369:403	Synthetic polymer-based air filter media not only has disposal issues but also is a source of air and water pollution at the end of their life cycle.
33264922	9	74	theme	green	1160:1164	arg1	filtration					1197:1206	a 'green' dual function respiratory air filtration	1157:1206	a 'green' dual function respiratory air filtration at low resistance	1157:1224	This study provides a solution for a 'green' dual function respiratory air filtration at low resistance.
33264922	0	75	from	resistance	135:144	arg1	filtration					70:79	filtration	70:79	filtration of aerosols and volatile organic compounds at low air resistance	70:144	Gelatin/β-Cyclodextrin Bio-Nanofibers as respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance.
33264922	3	76	theme	disposal	341:348	arg1	issues					350:355	disposal issues	341:355	disposal issues	341:355	Synthetic polymer-based air filter media not only has disposal issues but also is a source of air and water pollution at the end of their life cycle.
33264922	9	77	theme	function	1172:1179	arg1	filtration					1197:1206	a 'green' dual function respiratory air filtration	1157:1206	a 'green' dual function respiratory air filtration at low resistance	1157:1224	This study provides a solution for a 'green' dual function respiratory air filtration at low resistance.
33264922	8	78	theme	powder	1106:1111	arg1	samples					1113:1119	pristine powder samples	1097:1119	pristine powder samples	1097:1119	VOC adsorption of gelatin/β-cyclodextrin nanofibers is found several times higher than a commercial face mask and pristine powder samples.
33264922	9	79	theme	air	1193:1195	arg1	filtration					1197:1206	a 'green' dual function respiratory air filtration	1157:1206	a 'green' dual function respiratory air filtration at low resistance	1157:1224	This study provides a solution for a 'green' dual function respiratory air filtration at low resistance.
33264922	9	80	from	resistance	1215:1224	arg1	filtration					1197:1206	a 'green' dual function respiratory air filtration	1157:1206	a 'green' dual function respiratory air filtration at low resistance	1157:1224	This study provides a solution for a 'green' dual function respiratory air filtration at low resistance.
33264922	6	81	dep	efficiency	840:849	arg1	%					827:827	%	827:827	%	827:827	Gelatin/β-cyclodextrin nanofibers captured aerosols (0.3-5 μm) with < 95% filtration efficiency at 0.029/Pa quality factor.
32220668	4	0	theme	inclusion	702:710	arg1	IC					721:722	IC	721:722	IC	721:722	Characterization of the [Dmim][BF4]-α-CD inclusion complex (IC) by 1H NMR spectroscopy provided information about the complexation among the [Dmim][BF4] and α-CD molecules and the structure of the ICs.
32220668	4	0	theme	inclusion	702:710	arg1	complex					712:718	the [Dmim][BF4]-α-CD inclusion complex	681:718	the [Dmim][BF4]-α-CD inclusion complex (IC)	681:723	Characterization of the [Dmim][BF4]-α-CD inclusion complex (IC) by 1H NMR spectroscopy provided information about the complexation among the [Dmim][BF4] and α-CD molecules and the structure of the ICs.
32220668	1	1	theme	1-decyl-3-methylimidazolium	156:182	arg1	[BF4					208:211	ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4]	138:212	ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4]	138:212	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	1	1	theme	1-decyl-3-methylimidazolium	156:182	arg1	IL					152:153	IL	152:153	IL	152:153	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	3	2	with	concurrence	498:508	arg1	DLS					551:553	DLS	551:553	DLS	551:553	Here concurrence with FT-IR and dynamic light scattering (DLS) results, it is shown that α-CD interacts with [Dmim][BF4], induces compositional and structural changes.
32220668	3	2	with	concurrence	498:508	arg1	results					556:562	FT-IR and dynamic light scattering (DLS) results	515:562	FT-IR and dynamic light scattering (DLS) results	515:562	Here concurrence with FT-IR and dynamic light scattering (DLS) results, it is shown that α-CD interacts with [Dmim][BF4], induces compositional and structural changes.
32220668	0	3	from	investigation	20:32	arg1	complexation					51:62	the inclusion complexation	37:62	the inclusion complexation of α-cyclodextrin with long chain	37:96	Multi-spectroscopic investigation on the inclusion complexation of α-cyclodextrin with long chain ionic liquid.
32220668	5	4	theme	NMR	866:868	arg1	results					870:876	1H NMR results	863:876	1H NMR results	863:876	1H NMR results confirm the formation of inclusion complex (IC) while UV-vis spectroscopy, DLS and FTIR studies show development of IC with 1:1 stoichiometry.
32220668	1	5	theme	tetrafluoroborate	184:200	arg1	[BF4					208:211	ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4]	138:212	ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4]	138:212	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	1	5	theme	tetrafluoroborate	184:200	arg1	IL					152:153	IL	152:153	IL	152:153	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	1	6	theme	different	263:271	arg1	techniques					287:296	different spectroscopic techniques	263:296	different spectroscopic techniques	263:296	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	1	7	theme	chemistry	372:380	arg1	field					348:352	the field	344:352	the field of supramolecular chemistry and medicine	344:393	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	4	8	theme	ICs	858:860	arg1	complexation					779:790	the complexation	775:790	the complexation among the [Dmim][BF4] and α-CD molecules	775:831	Characterization of the [Dmim][BF4]-α-CD inclusion complex (IC) by 1H NMR spectroscopy provided information about the complexation among the [Dmim][BF4] and α-CD molecules and the structure of the ICs.
32220668	4	8	theme	ICs	858:860	arg1	structure					841:849	the structure	837:849	the structure of the ICs	837:860	Characterization of the [Dmim][BF4]-α-CD inclusion complex (IC) by 1H NMR spectroscopy provided information about the complexation among the [Dmim][BF4] and α-CD molecules and the structure of the ICs.
32220668	6	9	theme	pharmaceutical	1081:1094	arg1	fields					1071:1076	the fields	1067:1076	the fields of pharmaceutical science, supra-molecular chemistry and material science	1067:1150	The present study can be highly applicable in the fields of pharmaceutical science, supra-molecular chemistry and material science.
32220668	1	10	theme	spectroscopic	273:285	arg1	techniques					287:296	different spectroscopic techniques	263:296	different spectroscopic techniques	263:296	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	5	11	theme	inclusion	903:911	arg1	IC					922:923	IC	922:923	IC	922:923	1H NMR results confirm the formation of inclusion complex (IC) while UV-vis spectroscopy, DLS and FTIR studies show development of IC with 1:1 stoichiometry.
32220668	5	11	theme	inclusion	903:911	arg1	complex					913:919	inclusion complex	903:919	inclusion complex (IC)	903:924	1H NMR results confirm the formation of inclusion complex (IC) while UV-vis spectroscopy, DLS and FTIR studies show development of IC with 1:1 stoichiometry.
32220668	1	12	from	significant	329:339	arg1	field					348:352	the field	344:352	the field of supramolecular chemistry and medicine	344:393	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	3	13	dep	interacts	587:595	arg1	induces					615:621	induces	615:621	induces compositional and structural changes	615:658	Here concurrence with FT-IR and dynamic light scattering (DLS) results, it is shown that α-CD interacts with [Dmim][BF4], induces compositional and structural changes.
32220668	4	14	theme	-α-CD	696:700	arg1	IC					721:722	IC	721:722	IC	721:722	Characterization of the [Dmim][BF4]-α-CD inclusion complex (IC) by 1H NMR spectroscopy provided information about the complexation among the [Dmim][BF4] and α-CD molecules and the structure of the ICs.
32220668	4	14	theme	-α-CD	696:700	arg1	complex					712:718	the [Dmim][BF4]-α-CD inclusion complex	681:718	the [Dmim][BF4]-α-CD inclusion complex (IC)	681:723	Characterization of the [Dmim][BF4]-α-CD inclusion complex (IC) by 1H NMR spectroscopy provided information about the complexation among the [Dmim][BF4] and α-CD molecules and the structure of the ICs.
32220668	1	15	theme	medicine	386:393	arg1	field					348:352	the field	344:352	the field of supramolecular chemistry and medicine	344:393	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	5	16	theme	UV-vis	932:937	arg1	spectroscopy					939:950	UV-vis spectroscopy	932:950	UV-vis spectroscopy	932:950	1H NMR results confirm the formation of inclusion complex (IC) while UV-vis spectroscopy, DLS and FTIR studies show development of IC with 1:1 stoichiometry.
32220668	1	17	theme	[Dmim	202:206	arg1	[BF4					208:211	ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4]	138:212	ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4]	138:212	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	1	17	theme	[Dmim	202:206	arg1	IL					152:153	IL	152:153	IL	152:153	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	4	18	theme	α-CD	818:821	arg1	molecules					823:831	the [Dmim][BF4] and α-CD molecules	798:831	molecules	823:831	Characterization of the [Dmim][BF4]-α-CD inclusion complex (IC) by 1H NMR spectroscopy provided information about the complexation among the [Dmim][BF4] and α-CD molecules and the structure of the ICs.
32220668	0	19	theme	Multi-spectroscopic	0:18	arg1	investigation					20:32	Multi-spectroscopic investigation	0:32	Multi-spectroscopic investigation on the inclusion complexation of α-cyclodextrin with long chain	0:96	Multi-spectroscopic investigation on the inclusion complexation of α-cyclodextrin with long chain ionic liquid.
32220668	6	20	theme	present	1025:1031	arg1	applicable					1053:1062	applicable	1053:1062	applicable	1053:1062	The present study can be highly applicable in the fields of pharmaceutical science, supra-molecular chemistry and material science.
32220668	6	20	theme	present	1025:1031	arg1	study					1033:1037	The present study	1021:1037	The present study	1021:1037	The present study can be highly applicable in the fields of pharmaceutical science, supra-molecular chemistry and material science.
32220668	6	21	theme	supra-molecular	1105:1119	arg1	chemistry					1121:1129	science, supra-molecular chemistry	1096:1129	chemistry	1121:1129	The present study can be highly applicable in the fields of pharmaceutical science, supra-molecular chemistry and material science.
32220668	6	22	from	applicable	1053:1062	arg1	fields					1071:1076	the fields	1067:1076	the fields of pharmaceutical science, supra-molecular chemistry and material science	1067:1150	The present study can be highly applicable in the fields of pharmaceutical science, supra-molecular chemistry and material science.
32220668	4	23	theme	1H	728:729	arg1	spectroscopy					735:746	1H NMR spectroscopy	728:746	1H NMR spectroscopy	728:746	Characterization of the [Dmim][BF4]-α-CD inclusion complex (IC) by 1H NMR spectroscopy provided information about the complexation among the [Dmim][BF4] and α-CD molecules and the structure of the ICs.
32220668	1	24	theme	[BF4	208:211	arg1	interaction					123:133	Host-guest interaction	112:133	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD)	112:241	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	1	25	theme	supramolecular	357:370	arg1	chemistry					372:380	supramolecular chemistry	357:380	supramolecular chemistry	357:380	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	5	26	theme	complex	913:919	arg1	formation					890:898	the formation	886:898	the formation of inclusion complex (IC)	886:924	1H NMR results confirm the formation of inclusion complex (IC) while UV-vis spectroscopy, DLS and FTIR studies show development of IC with 1:1 stoichiometry.
32220668	2	27	theme	host-guest	468:477	arg1	complexation					479:490	the host-guest complexation	464:490	the host-guest complexation	464:490	Benesi-Hildebrand correlation is used to study the stoichiometry of the host-guest complexation.
32220668	1	28	theme	Host-guest	112:121	arg1	interaction					123:133	Host-guest interaction	112:133	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD)	112:241	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	1	29	theme	investigated	306:317	arg1	system					319:324	our investigated system	302:324	our investigated system	302:324	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	2	30	theme	complexation	479:490	arg1	stoichiometry					447:459	the stoichiometry	443:459	the stoichiometry of the host-guest complexation	443:490	Benesi-Hildebrand correlation is used to study the stoichiometry of the host-guest complexation.
32220668	4	31	theme	NMR	731:733	arg1	spectroscopy					735:746	1H NMR spectroscopy	728:746	1H NMR spectroscopy	728:746	Characterization of the [Dmim][BF4]-α-CD inclusion complex (IC) by 1H NMR spectroscopy provided information about the complexation among the [Dmim][BF4] and α-CD molecules and the structure of the ICs.
32220668	3	32	theme	FT-IR	515:519	arg1	DLS					551:553	DLS	551:553	DLS	551:553	Here concurrence with FT-IR and dynamic light scattering (DLS) results, it is shown that α-CD interacts with [Dmim][BF4], induces compositional and structural changes.
32220668	3	32	theme	FT-IR	515:519	arg1	results					556:562	FT-IR and dynamic light scattering (DLS) results	515:562	FT-IR and dynamic light scattering (DLS) results	515:562	Here concurrence with FT-IR and dynamic light scattering (DLS) results, it is shown that α-CD interacts with [Dmim][BF4], induces compositional and structural changes.
32220668	3	33	theme	scattering	539:548	arg1	DLS					551:553	DLS	551:553	DLS	551:553	Here concurrence with FT-IR and dynamic light scattering (DLS) results, it is shown that α-CD interacts with [Dmim][BF4], induces compositional and structural changes.
32220668	3	33	theme	scattering	539:548	arg1	results					556:562	FT-IR and dynamic light scattering (DLS) results	515:562	FT-IR and dynamic light scattering (DLS) results	515:562	Here concurrence with FT-IR and dynamic light scattering (DLS) results, it is shown that α-CD interacts with [Dmim][BF4], induces compositional and structural changes.
32220668	0	34	theme	inclusion	41:49	arg1	complexation					51:62	the inclusion complexation	37:62	the inclusion complexation of α-cyclodextrin with long chain	37:96	Multi-spectroscopic investigation on the inclusion complexation of α-cyclodextrin with long chain ionic liquid.
32220668	3	35	theme	structural	641:650	arg1	changes					652:658	compositional and structural changes	623:658	compositional and structural changes	623:658	Here concurrence with FT-IR and dynamic light scattering (DLS) results, it is shown that α-CD interacts with [Dmim][BF4], induces compositional and structural changes.
32220668	0	36	theme	α-cyclodextrin	67:80	arg1	complexation					51:62	the inclusion complexation	37:62	the inclusion complexation of α-cyclodextrin with long chain	37:96	Multi-spectroscopic investigation on the inclusion complexation of α-cyclodextrin with long chain ionic liquid.
32220668	3	37	theme	light	533:537	arg1	scattering					539:548	dynamic light scattering	525:548	dynamic light scattering	525:548	Here concurrence with FT-IR and dynamic light scattering (DLS) results, it is shown that α-CD interacts with [Dmim][BF4], induces compositional and structural changes.
32220668	6	38	theme	material	1135:1142	arg1	fields					1071:1076	the fields	1067:1076	the fields of pharmaceutical science, supra-molecular chemistry and material science	1067:1150	The present study can be highly applicable in the fields of pharmaceutical science, supra-molecular chemistry and material science.
32220668	5	39	theme	IC	994:995	arg1	development					979:989	development	979:989	development of IC	979:995	1H NMR results confirm the formation of inclusion complex (IC) while UV-vis spectroscopy, DLS and FTIR studies show development of IC with 1:1 stoichiometry.
32220668	6	40	theme	science	1096:1102	arg1	chemistry					1121:1129	science, supra-molecular chemistry	1096:1129	chemistry	1121:1129	The present study can be highly applicable in the fields of pharmaceutical science, supra-molecular chemistry and material science.
32220668	1	41	theme	ionic	138:142	arg1	[BF4					208:211	ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4]	138:212	ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4]	138:212	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	1	41	theme	ionic	138:142	arg1	IL					152:153	IL	152:153	IL	152:153	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	3	42	theme	compositional	623:635	arg1	changes					652:658	compositional and structural changes	623:658	compositional and structural changes	623:658	Here concurrence with FT-IR and dynamic light scattering (DLS) results, it is shown that α-CD interacts with [Dmim][BF4], induces compositional and structural changes.
32220668	6	43	from	fields	1071:1076	arg1	applicable					1053:1062	applicable	1053:1062	applicable	1053:1062	The present study can be highly applicable in the fields of pharmaceutical science, supra-molecular chemistry and material science.
32220668	6	43	from	fields	1071:1076	arg1	study					1033:1037	The present study	1021:1037	The present study	1021:1037	The present study can be highly applicable in the fields of pharmaceutical science, supra-molecular chemistry and material science.
32220668	1	44	theme	liquid	144:149	arg1	[BF4					208:211	ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4]	138:212	ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4]	138:212	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	1	44	theme	liquid	144:149	arg1	IL					152:153	IL	152:153	IL	152:153	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	0	45	with	complexation	51:62	arg1	chain					92:96	long chain	87:96	long chain	87:96	Multi-spectroscopic investigation on the inclusion complexation of α-cyclodextrin with long chain ionic liquid.
32220668	5	46	theme	1:1	1002:1004	arg1	stoichiometry					1006:1018	1:1 stoichiometry	1002:1018	1:1 stoichiometry	1002:1018	1H NMR results confirm the formation of inclusion complex (IC) while UV-vis spectroscopy, DLS and FTIR studies show development of IC with 1:1 stoichiometry.
32220668	3	47	theme	dynamic	525:531	arg1	scattering					539:548	dynamic light scattering	525:548	dynamic light scattering	525:548	Here concurrence with FT-IR and dynamic light scattering (DLS) results, it is shown that α-CD interacts with [Dmim][BF4], induces compositional and structural changes.
32220668	0	48	theme	long	87:90	arg1	chain					92:96	long chain	87:96	long chain	87:96	Multi-spectroscopic investigation on the inclusion complexation of α-cyclodextrin with long chain ionic liquid.
32220668	4	49	theme	[Dmim	802:806	arg1	[BF4					808:811	the [Dmim][BF4] and α-CD molecules	798:831	[BF4	808:811	Characterization of the [Dmim][BF4]-α-CD inclusion complex (IC) by 1H NMR spectroscopy provided information about the complexation among the [Dmim][BF4] and α-CD molecules and the structure of the ICs.
32220668	2	50	theme	Benesi-Hildebrand	396:412	arg1	correlation					414:424	Benesi-Hildebrand correlation	396:424	Benesi-Hildebrand correlation	396:424	Benesi-Hildebrand correlation is used to study the stoichiometry of the host-guest complexation.
32220668	6	51	dep	pharmaceutical	1081:1094	arg1	chemistry					1121:1129	science, supra-molecular chemistry	1096:1129	chemistry	1121:1129	The present study can be highly applicable in the fields of pharmaceutical science, supra-molecular chemistry and material science.
32220668	6	51	dep	pharmaceutical	1081:1094	arg1	science					1144:1150	science	1144:1150	science	1144:1150	The present study can be highly applicable in the fields of pharmaceutical science, supra-molecular chemistry and material science.
32220668	1	52	from	field	348:352	arg1	significant					329:339	significant	329:339	significant	329:339	Host-guest interaction of ionic liquid (IL) 1-decyl-3-methylimidazolium tetrafluoroborate [Dmim][BF4] within α-cyclodextrin (α-CD) has been studied by different spectroscopic techniques and our investigated system is significant in the field of supramolecular chemistry and medicine.
32220668	5	53	theme	FTIR	961:964	arg1	studies					966:972	FTIR studies	961:972	FTIR studies	961:972	1H NMR results confirm the formation of inclusion complex (IC) while UV-vis spectroscopy, DLS and FTIR studies show development of IC with 1:1 stoichiometry.
32220668	2	54	used	used	429:432	arg2	correlation					414:424	Benesi-Hildebrand correlation	396:424	Benesi-Hildebrand correlation	396:424	Benesi-Hildebrand correlation is used to study the stoichiometry of the host-guest complexation.
32220668	5	55	theme	1H	863:864	arg1	NMR					866:868	1H NMR	863:868	1H NMR results	863:876	1H NMR results confirm the formation of inclusion complex (IC) while UV-vis spectroscopy, DLS and FTIR studies show development of IC with 1:1 stoichiometry.
32220668	4	56	theme	complex	712:718	arg1	Characterization					661:676	Characterization	661:676	Characterization of the [Dmim][BF4]-α-CD inclusion complex (IC) by 1H NMR spectroscopy	661:746	Characterization of the [Dmim][BF4]-α-CD inclusion complex (IC) by 1H NMR spectroscopy provided information about the complexation among the [Dmim][BF4] and α-CD molecules and the structure of the ICs.
33631699	8	0	theme	improved	1275:1282	arg1	area					1301:1304	the improved specific surface area	1271:1304	the improved specific surface area	1271:1304	The possible adsorption mechanism was proposed, and the enhanced removal ability was due to the improved specific surface area and pore volume, which increased by about 20 and 14 times as compared with chitosan.
33631699	9	1	theme	better	1575:1580	arg1	performance					1582:1592	the better performance	1571:1592	the better performance of the composite than biochar alone due to the lack of functional groups on the biochar	1571:1680	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	6	2	theme	first	800:804	arg1	time					806:809	the first time	796:809	the first time	796:809	This study reports for the first time the removal of metals from OSPW under natural pH using Biochar/CS adsorbent.
33631699	12	3	theme	promising	1968:1976	arg1	composite					1947:1955	the Biochar/CS composite	1932:1955	the Biochar/CS composite	1932:1955	Overall, the Biochar/CS composite would be a promising and effective adsorbent for metals removal, owing to its advantages of being cost-effective and environmentally friendly.
33631699	12	3	theme	promising	1968:1976	arg1	removal					2013:2019	a promising and effective adsorbent for metals removal	1966:2019	a promising and effective adsorbent for metals removal	1966:2019	Overall, the Biochar/CS composite would be a promising and effective adsorbent for metals removal, owing to its advantages of being cost-effective and environmentally friendly.
33631699	12	4	dep	removal	2013:2019	arg1	owing					2022:2026	owing	2022:2026	owing to its advantages of being cost-effective	2022:2068	Overall, the Biochar/CS composite would be a promising and effective adsorbent for metals removal, owing to its advantages of being cost-effective and environmentally friendly.
33631699	12	4	dep	removal	2013:2019	arg1	friendly					2090:2097	friendly	2090:2097	friendly	2090:2097	Overall, the Biochar/CS composite would be a promising and effective adsorbent for metals removal, owing to its advantages of being cost-effective and environmentally friendly.
33631699	10	5	theme	second	1766:1771	arg1	order					1773:1777	pseudo second order	1759:1777	pseudo second order	1759:1777	Moreover, the adsorption process was best modelled by the Freundlich model, pseudo second order and intraparticle diffusion kinetic models.
33631699	9	6	theme	composite	1601:1609	arg1	performance					1582:1592	the better performance	1571:1592	the better performance of the composite than biochar alone due to the lack of functional groups on the biochar	1571:1680	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	4	7	theme	facile	555:560	arg1	method					575:580	a facile hydrothermal method	553:580	a facile hydrothermal method	553:580	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	0	8	theme	Biochar/Chitosan	90:105	arg1	composite					107:115	sludge-based Biochar/Chitosan composite	77:115	sludge-based Biochar/Chitosan composite	77:115	Adsorption of metals from oil sands process water (OSPW) under natural pH by sludge-based Biochar/Chitosan composite.
33631699	2	9	theme	excess	245:250	arg1	metals					252:257	excess metals	245:257	excess metals	245:257	Hence, the removal of excess metals from OSPW is of great significance.
33631699	5	10	theme	Brunauer-Emmett-Teller	736:757	arg1	method					765:770	Brunauer-Emmett-Teller (BET) method	736:770	Brunauer-Emmett-Teller (BET) method	736:770	The structural properties of the synthesized Biochar/CS composite were characterized via X-ray diffraction (XRD), scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) method.
33631699	8	11	theme	adsorption	1192:1201	arg1	mechanism					1203:1211	The possible adsorption mechanism	1179:1211	The possible adsorption mechanism	1179:1211	The possible adsorption mechanism was proposed, and the enhanced removal ability was due to the improved specific surface area and pore volume, which increased by about 20 and 14 times as compared with chitosan.
33631699	5	12	theme	Biochar/CS	628:637	arg1	composite					639:647	the synthesized Biochar/CS composite	612:647	the synthesized Biochar/CS composite	612:647	The structural properties of the synthesized Biochar/CS composite were characterized via X-ray diffraction (XRD), scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) method.
33631699	5	13	theme	BET	760:762	arg1	method					765:770	Brunauer-Emmett-Teller (BET) method	736:770	Brunauer-Emmett-Teller (BET) method	736:770	The structural properties of the synthesized Biochar/CS composite were characterized via X-ray diffraction (XRD), scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) method.
33631699	5	14	theme	structural	587:596	arg1	properties					598:607	The structural properties	583:607	The structural properties of the synthesized Biochar/CS composite	583:647	The structural properties of the synthesized Biochar/CS composite were characterized via X-ray diffraction (XRD), scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) method.
33631699	12	15	theme	effective	1982:1990	arg1	composite					1947:1955	the Biochar/CS composite	1932:1955	the Biochar/CS composite	1932:1955	Overall, the Biochar/CS composite would be a promising and effective adsorbent for metals removal, owing to its advantages of being cost-effective and environmentally friendly.
33631699	12	15	theme	effective	1982:1990	arg1	removal					2013:2019	a promising and effective adsorbent for metals removal	1966:2019	a promising and effective adsorbent for metals removal	1966:2019	Overall, the Biochar/CS composite would be a promising and effective adsorbent for metals removal, owing to its advantages of being cost-effective and environmentally friendly.
33631699	9	16	theme	groups	1660:1665	arg1	lack					1641:1644	the lack	1637:1644	the lack of functional groups on the biochar	1637:1680	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	10	17	theme	adsorption	1697:1706	arg1	process					1708:1714	the adsorption process	1693:1714	the adsorption process	1693:1714	Moreover, the adsorption process was best modelled by the Freundlich model, pseudo second order and intraparticle diffusion kinetic models.
33631699	9	18	theme	oxygen	1454:1459	arg1	groups					1472:1477	some oxygen containing groups	1449:1477	some oxygen containing groups	1449:1477	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	7	19	theme	Cr	1033:1034	arg1	concentrations					1015:1028	the initial concentrations	1003:1028	the initial concentrations of Cr, Cu, Se and Pb	1003:1049	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	7	19	theme	Cr	1033:1034	arg1	0.02914					1056:1062	0.02914	1056:1062	0.02914	1056:1062	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	0	20	theme	metals	14:19	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of metals from oil	0:28	Adsorption of metals from oil sands process water (OSPW) under natural pH by sludge-based Biochar/Chitosan composite.
33631699	8	21	theme	removal	1244:1250	arg1	due					1264:1266	due	1264:1266	due	1264:1266	The possible adsorption mechanism was proposed, and the enhanced removal ability was due to the improved specific surface area and pore volume, which increased by about 20 and 14 times as compared with chitosan.
33631699	8	21	theme	removal	1244:1250	arg1	ability					1252:1258	the enhanced removal ability	1231:1258	the enhanced removal ability	1231:1258	The possible adsorption mechanism was proposed, and the enhanced removal ability was due to the improved specific surface area and pore volume, which increased by about 20 and 14 times as compared with chitosan.
33631699	1	22	theme	sands	137:141	arg1	OSPW					158:161	OSPW	158:161	OSPW	158:161	Some metals in oil sands process water (OSPW) are potential threats to human health and the environment.
33631699	1	22	theme	sands	137:141	arg1	water					151:155	oil sands process water	133:155	oil sands process water (OSPW)	133:162	Some metals in oil sands process water (OSPW) are potential threats to human health and the environment.
33631699	2	23	from	OSPW	264:267	arg1	removal					234:240	the removal	230:240	the removal of excess metals from OSPW	230:267	Hence, the removal of excess metals from OSPW is of great significance.
33631699	0	24	from	Adsorption	0:9	arg1	oil					26:28	oil	26:28	oil	26:28	Adsorption of metals from oil sands process water (OSPW) under natural pH by sludge-based Biochar/Chitosan composite.
33631699	0	25	theme	natural	63:69	arg1	pH					71:72	natural pH	63:72	natural pH	63:72	Adsorption of metals from oil sands process water (OSPW) under natural pH by sludge-based Biochar/Chitosan composite.
33631699	1	26	from	metals	123:128	arg1	OSPW					158:161	OSPW	158:161	OSPW	158:161	Some metals in oil sands process water (OSPW) are potential threats to human health and the environment.
33631699	1	26	from	metals	123:128	arg1	water					151:155	oil sands process water	133:155	oil sands process water (OSPW)	133:162	Some metals in oil sands process water (OSPW) are potential threats to human health and the environment.
33631699	7	27	dep	exhibited	902:910	arg1	compared					1138:1145	compared	1138:1145	compared with biochar or chitosan alone	1138:1176	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	3	28	theme	sludge	320:325	arg1	waste					327:331	anaerobic sludge waste	310:331	anaerobic sludge waste	310:331	In this study, anaerobic sludge waste from a wastewater treatment plant, was reused to prepare sludge-based biochar.
33631699	0	29	from	oil	26:28	arg1	metals					14:19	metals	14:19	metals from oil	14:28	Adsorption of metals from oil sands process water (OSPW) under natural pH by sludge-based Biochar/Chitosan composite.
33631699	0	29	from	oil	26:28	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of metals from oil	0:28	Adsorption of metals from oil sands process water (OSPW) under natural pH by sludge-based Biochar/Chitosan composite.
33631699	9	30	theme	removal	1519:1525	arg1	reason					1560:1565	the reason	1556:1565	the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar	1556:1680	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	9	30	theme	removal	1519:1525	arg1	ability					1527:1533	the enhanced removal ability	1506:1533	the enhanced removal ability	1506:1533	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	8	31	theme	surface	1293:1299	arg1	area					1301:1304	the improved specific surface area	1271:1304	the improved specific surface area	1271:1304	The possible adsorption mechanism was proposed, and the enhanced removal ability was due to the improved specific surface area and pore volume, which increased by about 20 and 14 times as compared with chitosan.
33631699	3	32	theme	sludge-based	390:401	arg1	biochar					403:409	sludge-based biochar	390:409	sludge-based biochar	390:409	In this study, anaerobic sludge waste from a wastewater treatment plant, was reused to prepare sludge-based biochar.
33631699	4	33	from	metals	492:497	arg1	OSPW					527:530	real OSPW	522:530	real OSPW	522:530	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	9	34	from	groups	1660:1665	arg1	biochar					1674:1680	the biochar	1670:1680	the biochar	1670:1680	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	3	35	theme	wastewater	340:349	arg1	plant					361:365	a wastewater treatment plant	338:365	a wastewater treatment plant	338:365	In this study, anaerobic sludge waste from a wastewater treatment plant, was reused to prepare sludge-based biochar.
33631699	10	36	theme	diffusion	1797:1805	arg1	models					1815:1820	intraparticle diffusion kinetic models	1783:1820	intraparticle diffusion kinetic models	1783:1820	Moreover, the adsorption process was best modelled by the Freundlich model, pseudo second order and intraparticle diffusion kinetic models.
33631699	3	37	theme	treatment	351:359	arg1	plant					361:365	a wastewater treatment plant	338:365	a wastewater treatment plant	338:365	In this study, anaerobic sludge waste from a wastewater treatment plant, was reused to prepare sludge-based biochar.
33631699	0	38	dep	process	36:42	arg1	OSPW					51:54	OSPW	51:54	OSPW	51:54	Adsorption of metals from oil sands process water (OSPW) under natural pH by sludge-based Biochar/Chitosan composite.
33631699	0	38	dep	process	36:42	arg1	water					44:48	water	44:48	process water (OSPW)	36:55	Adsorption of metals from oil sands process water (OSPW) under natural pH by sludge-based Biochar/Chitosan composite.
33631699	4	39	theme	excellent	459:467	arg1	efficiency					477:486	excellent removal efficiency	459:486	excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW	459:530	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	11	40	theme	removal	1906:1912	arg1	process					1914:1920	the removal process	1902:1920	the removal process	1902:1920	The results indicated that chemical adsorption might play the dominant role in the removal process.
33631699	5	41	theme	electron	706:713	arg1	SEM					727:729	SEM	727:729	SEM	727:729	The structural properties of the synthesized Biochar/CS composite were characterized via X-ray diffraction (XRD), scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) method.
33631699	5	41	theme	electron	706:713	arg1	microscopy					715:724	scanning electron microscopy	697:724	scanning electron microscopy (SEM)	697:730	The structural properties of the synthesized Biochar/CS composite were characterized via X-ray diffraction (XRD), scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) method.
33631699	6	42	from	OSPW	838:841	arg1	removal					815:821	the removal	811:821	the removal of metals from OSPW	811:841	This study reports for the first time the removal of metals from OSPW under natural pH using Biochar/CS adsorbent.
33631699	7	43	theme	Pb	1048:1049	arg1	concentrations					1015:1028	the initial concentrations	1003:1028	the initial concentrations of Cr, Cu, Se and Pb	1003:1049	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	7	43	theme	Pb	1048:1049	arg1	0.02914					1056:1062	0.02914	1056:1062	0.02914	1056:1062	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	8	44	theme	possible	1183:1190	arg1	mechanism					1203:1211	The possible adsorption mechanism	1179:1211	The possible adsorption mechanism	1179:1211	The possible adsorption mechanism was proposed, and the enhanced removal ability was due to the improved specific surface area and pore volume, which increased by about 20 and 14 times as compared with chitosan.
33631699	7	45	theme	Se	1041:1042	arg1	concentrations					1015:1028	the initial concentrations	1003:1028	the initial concentrations of Cr, Cu, Se and Pb	1003:1049	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	7	45	theme	Se	1041:1042	arg1	0.02914					1056:1062	0.02914	1056:1062	0.02914	1056:1062	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	7	46	theme	Cu	1037:1038	arg1	concentrations					1015:1028	the initial concentrations	1003:1028	the initial concentrations of Cr, Cu, Se and Pb	1003:1049	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	7	46	theme	Cu	1037:1038	arg1	0.02914					1056:1062	0.02914	1056:1062	0.02914	1056:1062	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	10	47	theme	pseudo	1759:1764	arg1	order					1773:1777	pseudo second order	1759:1777	pseudo second order	1759:1777	Moreover, the adsorption process was best modelled by the Freundlich model, pseudo second order and intraparticle diffusion kinetic models.
33631699	9	48	theme	Functional	1391:1400	arg1	groups					1472:1477	some oxygen containing groups	1449:1477	some oxygen containing groups	1449:1477	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	9	48	theme	Functional	1391:1400	arg1	-OH					1441:1443	-OH	1441:1443	-OH	1441:1443	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	9	48	theme	Functional	1391:1400	arg1	-NH2					1435:1438	-NH2	1435:1438	-NH2	1435:1438	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	9	48	theme	Functional	1391:1400	arg1	groups					1402:1407	Functional groups	1391:1407	Functional groups	1391:1407	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	10	49	theme	kinetic	1807:1813	arg1	models					1815:1820	intraparticle diffusion kinetic models	1783:1820	intraparticle diffusion kinetic models	1783:1820	Moreover, the adsorption process was best modelled by the Freundlich model, pseudo second order and intraparticle diffusion kinetic models.
33631699	1	50	theme	process	143:149	arg1	OSPW					158:161	OSPW	158:161	OSPW	158:161	Some metals in oil sands process water (OSPW) are potential threats to human health and the environment.
33631699	1	50	theme	process	143:149	arg1	water					151:155	oil sands process water	133:155	oil sands process water (OSPW)	133:162	Some metals in oil sands process water (OSPW) are potential threats to human health and the environment.
33631699	10	51	theme	intraparticle	1783:1795	arg1	models					1815:1820	intraparticle diffusion kinetic models	1783:1820	intraparticle diffusion kinetic models	1783:1820	Moreover, the adsorption process was best modelled by the Freundlich model, pseudo second order and intraparticle diffusion kinetic models.
33631699	4	52	theme	hydrothermal	562:573	arg1	method					575:580	a facile hydrothermal method	553:580	a facile hydrothermal method	553:580	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	2	53	theme	metals	252:257	arg1	removal					234:240	the removal	230:240	the removal of excess metals from OSPW	230:267	Hence, the removal of excess metals from OSPW is of great significance.
33631699	9	54	from	groups	1402:1407	arg1	composite					1416:1424	composite	1416:1424	composite	1416:1424	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	2	55	theme	great	275:279	arg1	significance					281:292	great significance	275:292	great significance	275:292	Hence, the removal of excess metals from OSPW is of great significance.
33631699	5	56	theme	synthesized	616:626	arg1	composite					639:647	the synthesized Biochar/CS composite	612:647	the synthesized Biochar/CS composite	612:647	The structural properties of the synthesized Biochar/CS composite were characterized via X-ray diffraction (XRD), scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) method.
33631699	1	57	theme	potential	168:176	arg1	metals					123:128	Some metals	118:128	Some metals in oil sands process water (OSPW)	118:162	Some metals in oil sands process water (OSPW) are potential threats to human health and the environment.
33631699	1	57	theme	potential	168:176	arg1	threats					178:184	potential threats	168:184	potential threats to human health and the environment	168:220	Some metals in oil sands process water (OSPW) are potential threats to human health and the environment.
33631699	7	58	theme	higher	914:919	arg1	efficiency					929:938	a higher removal efficiency	912:938	a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%)	912:996	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	4	59	theme	adsorbent	444:452	arg1	Biochar/Chitosan					414:429	A Biochar/Chitosan	412:429	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW	412:530	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	4	59	theme	adsorbent	444:452	arg1	Biochar/CS					432:441	Biochar/CS	432:441	Biochar/CS	432:441	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	6	60	theme	metals	826:831	arg1	removal					815:821	the removal	811:821	the removal of metals from OSPW	811:841	This study reports for the first time the removal of metals from OSPW under natural pH using Biochar/CS adsorbent.
33631699	12	61	theme	adsorbent	1992:2000	arg1	composite					1947:1955	the Biochar/CS composite	1932:1955	the Biochar/CS composite	1932:1955	Overall, the Biochar/CS composite would be a promising and effective adsorbent for metals removal, owing to its advantages of being cost-effective and environmentally friendly.
33631699	12	61	theme	adsorbent	1992:2000	arg1	removal					2013:2019	a promising and effective adsorbent for metals removal	1966:2019	a promising and effective adsorbent for metals removal	1966:2019	Overall, the Biochar/CS composite would be a promising and effective adsorbent for metals removal, owing to its advantages of being cost-effective and environmentally friendly.
33631699	7	62	theme	0.5 g/L	1129:1135	arg1	dosage					1119:1124	a dosage	1117:1124	a dosage of 0.5 g/L	1117:1135	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	9	63	theme	functional	1649:1658	arg1	groups					1660:1665	functional groups	1649:1665	functional groups on the biochar	1649:1680	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	7	64	theme	removal	921:927	arg1	efficiency					929:938	a higher removal efficiency	912:938	a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%)	912:996	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	8	65	theme	enhanced	1235:1242	arg1	due					1264:1266	due	1264:1266	due	1264:1266	The possible adsorption mechanism was proposed, and the enhanced removal ability was due to the improved specific surface area and pore volume, which increased by about 20 and 14 times as compared with chitosan.
33631699	8	65	theme	enhanced	1235:1242	arg1	ability					1252:1258	the enhanced removal ability	1231:1258	the enhanced removal ability	1231:1258	The possible adsorption mechanism was proposed, and the enhanced removal ability was due to the improved specific surface area and pore volume, which increased by about 20 and 14 times as compared with chitosan.
33631699	5	66	theme	X-ray	672:676	arg1	diffraction					678:688	X-ray diffraction	672:688	X-ray diffraction (XRD)	672:694	The structural properties of the synthesized Biochar/CS composite were characterized via X-ray diffraction (XRD), scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) method.
33631699	5	66	theme	X-ray	672:676	arg1	XRD					691:693	XRD	691:693	XRD	691:693	The structural properties of the synthesized Biochar/CS composite were characterized via X-ray diffraction (XRD), scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) method.
33631699	9	67	theme	containing	1461:1470	arg1	groups					1472:1477	some oxygen containing groups	1449:1477	some oxygen containing groups	1449:1477	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	7	68	theme	initial	1007:1013	arg1	concentrations					1015:1028	the initial concentrations	1003:1028	the initial concentrations of Cr, Cu, Se and Pb	1003:1049	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	7	68	theme	initial	1007:1013	arg1	0.02914					1056:1062	0.02914	1056:1062	0.02914	1056:1062	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	6	69	theme	natural	849:855	arg1	pH					857:858	natural pH	849:858	natural pH using Biochar/CS adsorbent	849:885	This study reports for the first time the removal of metals from OSPW under natural pH using Biochar/CS adsorbent.
33631699	1	70	theme	oil	133:135	arg1	OSPW					158:161	OSPW	158:161	OSPW	158:161	Some metals in oil sands process water (OSPW) are potential threats to human health and the environment.
33631699	1	70	theme	oil	133:135	arg1	water					151:155	oil sands process water	133:155	oil sands process water (OSPW)	133:162	Some metals in oil sands process water (OSPW) are potential threats to human health and the environment.
33631699	5	71	theme	composite	639:647	arg1	properties					598:607	The structural properties	583:607	The structural properties of the synthesized Biochar/CS composite	583:647	The structural properties of the synthesized Biochar/CS composite were characterized via X-ray diffraction (XRD), scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) method.
33631699	6	72	theme	adsorbent	877:885	arg1	Biochar/CS					866:875	Biochar/CS adsorbent	866:885	Biochar/CS adsorbent	866:885	This study reports for the first time the removal of metals from OSPW under natural pH using Biochar/CS adsorbent.
33631699	12	73	theme	Biochar/CS	1936:1945	arg1	composite					1947:1955	the Biochar/CS composite	1932:1955	the Biochar/CS composite	1932:1955	Overall, the Biochar/CS composite would be a promising and effective adsorbent for metals removal, owing to its advantages of being cost-effective and environmentally friendly.
33631699	12	73	theme	Biochar/CS	1936:1945	arg1	removal					2013:2019	a promising and effective adsorbent for metals removal	1966:2019	a promising and effective adsorbent for metals removal	1966:2019	Overall, the Biochar/CS composite would be a promising and effective adsorbent for metals removal, owing to its advantages of being cost-effective and environmentally friendly.
33631699	0	74	theme	sludge-based	77:88	arg1	composite					107:115	sludge-based Biochar/Chitosan composite	77:115	sludge-based Biochar/Chitosan composite	77:115	Adsorption of metals from oil sands process water (OSPW) under natural pH by sludge-based Biochar/Chitosan composite.
33631699	9	75	from	biochar	1674:1680	arg1	lack					1641:1644	the lack	1637:1644	the lack of functional groups on the biochar	1637:1680	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	8	76	theme	specific	1284:1291	arg1	area					1301:1304	the improved specific surface area	1271:1304	the improved specific surface area	1271:1304	The possible adsorption mechanism was proposed, and the enhanced removal ability was due to the improved specific surface area and pore volume, which increased by about 20 and 14 times as compared with chitosan.
33631699	4	77	dep	metals	492:497	arg1	Se					508:509	Se	508:509	Se	508:509	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	4	77	dep	metals	492:497	arg1	Cu					504:505	Cu	504:505	Cu	504:505	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	4	77	dep	metals	492:497	arg1	Cr					500:501	Cr	500:501	Cr	500:501	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	4	77	dep	metals	492:497	arg1	metals					492:497	metals	492:497	metals (Cr, Cu, Se and Pb) in real OSPW	492:530	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	4	77	dep	metals	492:497	arg1	Pb					515:516	Pb	515:516	Pb	515:516	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	7	78	from	dosage	1119:1124	arg1	concentrations					1015:1028	the initial concentrations	1003:1028	the initial concentrations of Cr, Cu, Se and Pb	1003:1049	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	7	78	from	dosage	1119:1124	arg1	0.02914					1056:1062	0.02914	1056:1062	0.02914	1056:1062	The composite exhibited a higher removal efficiency towards Cr (83.9%), Cu (97.5%), Se (87.9%) and Pb (94.3%) when the initial concentrations of Cr, Cu, Se and Pb were 0.02914, 0.06185, 0.00800 and 0.00516 mg/L, respectively, at a dosage of 0.5 g/L, compared with biochar or chitosan alone.
33631699	9	79	theme	enhanced	1510:1517	arg1	reason					1560:1565	the reason	1556:1565	the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar	1556:1680	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	9	79	theme	enhanced	1510:1517	arg1	ability					1527:1533	the enhanced removal ability	1506:1533	the enhanced removal ability	1506:1533	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	3	80	theme	anaerobic	310:318	arg1	waste					327:331	anaerobic sludge waste	310:331	anaerobic sludge waste	310:331	In this study, anaerobic sludge waste from a wastewater treatment plant, was reused to prepare sludge-based biochar.
33631699	8	81	theme	pore	1310:1313	arg1	volume					1315:1320	pore volume	1310:1320	pore volume	1310:1320	The possible adsorption mechanism was proposed, and the enhanced removal ability was due to the improved specific surface area and pore volume, which increased by about 20 and 14 times as compared with chitosan.
33631699	9	82	from	lack	1641:1644	arg1	biochar					1674:1680	the biochar	1670:1680	the biochar	1670:1680	Functional groups in the composite, such as -NH2, -OH and some oxygen containing groups, were also responsible for the enhanced removal ability, which also might be the reason for the better performance of the composite than biochar alone due to the lack of functional groups on the biochar.
33631699	11	83	theme	dominant	1885:1892	arg1	role					1894:1897	the dominant role	1881:1897	the dominant role	1881:1897	The results indicated that chemical adsorption might play the dominant role in the removal process.
33631699	4	84	theme	removal	469:475	arg1	efficiency					477:486	excellent removal efficiency	459:486	excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW	459:530	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	5	85	theme	scanning	697:704	arg1	SEM					727:729	SEM	727:729	SEM	727:729	The structural properties of the synthesized Biochar/CS composite were characterized via X-ray diffraction (XRD), scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) method.
33631699	5	85	theme	scanning	697:704	arg1	microscopy					715:724	scanning electron microscopy	697:724	scanning electron microscopy (SEM)	697:730	The structural properties of the synthesized Biochar/CS composite were characterized via X-ray diffraction (XRD), scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) method.
33631699	4	86	with	adsorbent	444:452	arg1	efficiency					477:486	excellent removal efficiency	459:486	excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW	459:530	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	10	87	theme	Freundlich	1741:1750	arg1	model					1752:1756	the Freundlich model	1737:1756	the Freundlich model	1737:1756	Moreover, the adsorption process was best modelled by the Freundlich model, pseudo second order and intraparticle diffusion kinetic models.
33631699	3	88	from	plant	361:365	arg1	waste					327:331	anaerobic sludge waste	310:331	anaerobic sludge waste	310:331	In this study, anaerobic sludge waste from a wastewater treatment plant, was reused to prepare sludge-based biochar.
33631699	1	89	theme	human	189:193	arg1	health					195:200	human health	189:200	human health	189:200	Some metals in oil sands process water (OSPW) are potential threats to human health and the environment.
33631699	4	90	theme	real	522:525	arg1	OSPW					527:530	real OSPW	522:530	real OSPW	522:530	A Biochar/Chitosan (Biochar/CS) adsorbent with excellent removal efficiency for metals (Cr, Cu, Se and Pb) in real OSPW was prepared through a facile hydrothermal method.
33631699	11	91	theme	chemical	1850:1857	arg1	adsorption					1859:1868	chemical adsorption	1850:1868	chemical adsorption	1850:1868	The results indicated that chemical adsorption might play the dominant role in the removal process.
33484804	0	0	theme	cellulose/polyaniline/nano-clay	103:133	arg1	template					81:88	nanofibrillated template	65:88	nanofibrillated template of bacterial cellulose/polyaniline/nano-clay	65:133	Electrically conductive biocompatible composite aerogel based on nanofibrillated template of bacterial cellulose/polyaniline/nano-clay.
33484804	6	1	theme	aerogels	946:953	arg1	stability					909:917	Thermal stability	901:917	Thermal stability	901:917	Thermal stability and storage modulus of the aerogels was improved by inclusion of PANI and nano-clay.
33484804	6	1	theme	aerogels	946:953	arg1	modulus					931:937	storage modulus	923:937	storage modulus	923:937	Thermal stability and storage modulus of the aerogels was improved by inclusion of PANI and nano-clay.
33484804	7	2	theme	cell	1071:1074	arg1	adhesion					1076:1083	cell adhesion	1071:1083	cell adhesion	1071:1083	Synergistic effect of clay and polyaniline on biocompatibility and cell adhesion was obtained with no mutagenic or carcinogenic effects.
33484804	3	3	theme	interconnected	534:547	arg1	network					549:555	a double interconnected network	525:555	a double interconnected network of electrically conductive path within the aerogel	525:606	Clay nanoplatelets were dispersed in the BC membrane to form a nanofibrillated template for aniline in-situ polymerization leading to formation of a double interconnected network of electrically conductive path within the aerogel.
33484804	4	4	theme	particles	628:636	arg1	Deposition					609:618	Deposition	609:618	Deposition of PANI particles on BC/clay nanocomposite	609:661	Deposition of PANI particles on BC/clay nanocomposite was confirmed by FTIR, XRD, FESEM, and EDX techniques.
33484804	0	5	theme	bacterial	93:101	arg1	cellulose/polyaniline/nano-clay					103:133	bacterial cellulose/polyaniline/nano-clay	93:133	bacterial cellulose/polyaniline/nano-clay	93:133	Electrically conductive biocompatible composite aerogel based on nanofibrillated template of bacterial cellulose/polyaniline/nano-clay.
33484804	8	6	theme	suitable	1217:1224	arg1	aerogels					1189:1196	The developed electrically conductive composite aerogels	1141:1196	The developed electrically conductive composite aerogels	1141:1196	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	8	6	theme	suitable	1217:1224	arg1	scaffolds					1226:1234	suitable scaffolds	1217:1234	suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility	1217:1366	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	3	7	theme	network	549:555	arg1	formation					512:520	formation	512:520	formation of a double interconnected network of electrically conductive path within the aerogel	512:606	Clay nanoplatelets were dispersed in the BC membrane to form a nanofibrillated template for aniline in-situ polymerization leading to formation of a double interconnected network of electrically conductive path within the aerogel.
33484804	4	8	theme	PANI	623:626	arg1	particles					628:636	PANI particles	623:636	PANI particles	623:636	Deposition of PANI particles on BC/clay nanocomposite was confirmed by FTIR, XRD, FESEM, and EDX techniques.
33484804	5	9	dep	16	842:843	arg1	folds					845:849	folds	845:849	folds higher than that of the sample without nano-clay	845:898	The surface electrical conductivity of 0.49 S/cm was obtained for the composite aerogel comprising 5 wt% nano-clay which is 16 folds higher than that of the sample without nano-clay.
33484804	4	10	theme	BC/clay	641:647	arg1	nanocomposite					649:661	BC/clay nanocomposite	641:661	BC/clay nanocomposite	641:661	Deposition of PANI particles on BC/clay nanocomposite was confirmed by FTIR, XRD, FESEM, and EDX techniques.
33484804	6	11	theme	storage	923:929	arg1	modulus					931:937	storage modulus	923:937	storage modulus	923:937	Thermal stability and storage modulus of the aerogels was improved by inclusion of PANI and nano-clay.
33484804	8	12	theme	dimensional	1313:1323	arg1	balance					1289:1295	a good balance	1282:1295	a good balance of flexibility, dimensional and thermal stability and biocompatibility	1282:1366	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	4	13	theme	FTIR	680:683	arg1	techniques					706:715	FTIR, XRD, FESEM, and EDX techniques	680:715	FTIR, XRD, FESEM, and EDX techniques	680:715	Deposition of PANI particles on BC/clay nanocomposite was confirmed by FTIR, XRD, FESEM, and EDX techniques.
33484804	3	14	theme	conductive	573:582	arg1	path					584:587	electrically conductive path	560:587	electrically conductive path	560:587	Clay nanoplatelets were dispersed in the BC membrane to form a nanofibrillated template for aniline in-situ polymerization leading to formation of a double interconnected network of electrically conductive path within the aerogel.
33484804	4	15	theme	EDX	702:704	arg1	techniques					706:715	FTIR, XRD, FESEM, and EDX techniques	680:715	FTIR, XRD, FESEM, and EDX techniques	680:715	Deposition of PANI particles on BC/clay nanocomposite was confirmed by FTIR, XRD, FESEM, and EDX techniques.
33484804	1	16	theme	3D	193:194	arg1	structure					196:204	its porous and 3D structure	178:204	structure	196:204	Bacterial cellulose (BC) aerogel owing to its porous and 3D structure, poses a suitable matrix for embedding nanomaterials and polymers.
33484804	3	17	theme	Clay	378:381	arg1	nanoplatelets					383:395	Clay nanoplatelets	378:395	Clay nanoplatelets	378:395	Clay nanoplatelets were dispersed in the BC membrane to form a nanofibrillated template for aniline in-situ polymerization leading to formation of a double interconnected network of electrically conductive path within the aerogel.
33484804	3	18	theme	path	584:587	arg1	network					549:555	a double interconnected network	525:555	a double interconnected network of electrically conductive path within the aerogel	525:606	Clay nanoplatelets were dispersed in the BC membrane to form a nanofibrillated template for aniline in-situ polymerization leading to formation of a double interconnected network of electrically conductive path within the aerogel.
33484804	3	19	theme	aniline	470:476	arg1	polymerization					486:499	aniline in-situ polymerization	470:499	aniline in-situ polymerization leading to formation of a double interconnected network of electrically conductive path within the aerogel	470:606	Clay nanoplatelets were dispersed in the BC membrane to form a nanofibrillated template for aniline in-situ polymerization leading to formation of a double interconnected network of electrically conductive path within the aerogel.
33484804	0	20	theme	conductive	13:22	arg1	aerogel					48:54	Electrically conductive biocompatible composite aerogel	0:54	Electrically conductive biocompatible composite aerogel	0:54	Electrically conductive biocompatible composite aerogel based on nanofibrillated template of bacterial cellulose/polyaniline/nano-clay.
33484804	5	21	theme	5 wt	817:820	arg1	nano-clay					823:831	5 wt% nano-clay	817:831	5 wt% nano-clay which is 16 folds higher than that of the sample without nano-clay	817:898	The surface electrical conductivity of 0.49 S/cm was obtained for the composite aerogel comprising 5 wt% nano-clay which is 16 folds higher than that of the sample without nano-clay.
33484804	8	22	used	utilized	1205:1212	arg2	scaffolds					1226:1234	suitable scaffolds	1217:1234	suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility	1217:1366	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	8	22	used	utilized	1205:1212	arg2	aerogels					1189:1196	The developed electrically conductive composite aerogels	1141:1196	The developed electrically conductive composite aerogels	1141:1196	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	3	23	theme	nanofibrillated	441:455	arg1	template					457:464	a nanofibrillated template	439:464	a nanofibrillated template for aniline in-situ polymerization leading to formation of a double interconnected network of electrically conductive path within the aerogel	439:606	Clay nanoplatelets were dispersed in the BC membrane to form a nanofibrillated template for aniline in-situ polymerization leading to formation of a double interconnected network of electrically conductive path within the aerogel.
33484804	3	24	theme	BC	419:420	arg1	membrane					422:429	the BC membrane	415:429	the BC membrane	415:429	Clay nanoplatelets were dispersed in the BC membrane to form a nanofibrillated template for aniline in-situ polymerization leading to formation of a double interconnected network of electrically conductive path within the aerogel.
33484804	7	25	theme	carcinogenic	1119:1130	arg1	effects					1132:1138	no mutagenic or carcinogenic effects	1103:1138	no mutagenic or carcinogenic effects	1103:1138	Synergistic effect of clay and polyaniline on biocompatibility and cell adhesion was obtained with no mutagenic or carcinogenic effects.
33484804	1	26	theme	Bacterial	136:144	arg1	aerogel					161:167	Bacterial cellulose (BC) aerogel	136:167	Bacterial cellulose (BC) aerogel	136:167	Bacterial cellulose (BC) aerogel owing to its porous and 3D structure, poses a suitable matrix for embedding nanomaterials and polymers.
33484804	0	27	theme	composite	38:46	arg1	aerogel					48:54	Electrically conductive biocompatible composite aerogel	0:54	Electrically conductive biocompatible composite aerogel	0:54	Electrically conductive biocompatible composite aerogel based on nanofibrillated template of bacterial cellulose/polyaniline/nano-clay.
33484804	4	28	from	Deposition	609:618	arg1	nanocomposite					649:661	BC/clay nanocomposite	641:661	BC/clay nanocomposite	641:661	Deposition of PANI particles on BC/clay nanocomposite was confirmed by FTIR, XRD, FESEM, and EDX techniques.
33484804	5	29	theme	electrical	730:739	arg1	conductivity					741:752	The surface electrical conductivity	718:752	The surface electrical conductivity of 0.49 S/cm	718:765	The surface electrical conductivity of 0.49 S/cm was obtained for the composite aerogel comprising 5 wt% nano-clay which is 16 folds higher than that of the sample without nano-clay.
33484804	1	30	theme	cellulose	146:154	arg1	aerogel					161:167	Bacterial cellulose (BC) aerogel	136:167	Bacterial cellulose (BC) aerogel	136:167	Bacterial cellulose (BC) aerogel owing to its porous and 3D structure, poses a suitable matrix for embedding nanomaterials and polymers.
33484804	8	31	theme	thermal	1329:1335	arg1	stability					1337:1345	thermal stability	1329:1345	thermal stability	1329:1345	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	0	32	theme	biocompatible	24:36	arg1	aerogel					48:54	Electrically conductive biocompatible composite aerogel	0:54	Electrically conductive biocompatible composite aerogel	0:54	Electrically conductive biocompatible composite aerogel based on nanofibrillated template of bacterial cellulose/polyaniline/nano-clay.
33484804	7	33	theme	mutagenic	1106:1114	arg1	effects					1132:1138	no mutagenic or carcinogenic effects	1103:1138	no mutagenic or carcinogenic effects	1103:1138	Synergistic effect of clay and polyaniline on biocompatibility and cell adhesion was obtained with no mutagenic or carcinogenic effects.
33484804	6	34	theme	Thermal	901:907	arg1	stability					909:917	Thermal stability	901:917	Thermal stability	901:917	Thermal stability and storage modulus of the aerogels was improved by inclusion of PANI and nano-clay.
33484804	1	35	theme	suitable	215:222	arg1	matrix					224:229	a suitable matrix	213:229	a suitable matrix for embedding nanomaterials and polymers	213:270	Bacterial cellulose (BC) aerogel owing to its porous and 3D structure, poses a suitable matrix for embedding nanomaterials and polymers.
33484804	5	36	theme	%	821:821	arg1	nano-clay					823:831	5 wt% nano-clay	817:831	5 wt% nano-clay which is 16 folds higher than that of the sample without nano-clay	817:898	The surface electrical conductivity of 0.49 S/cm was obtained for the composite aerogel comprising 5 wt% nano-clay which is 16 folds higher than that of the sample without nano-clay.
33484804	3	37	theme	double	527:532	arg1	network					549:555	a double interconnected network	525:555	a double interconnected network of electrically conductive path within the aerogel	525:606	Clay nanoplatelets were dispersed in the BC membrane to form a nanofibrillated template for aniline in-situ polymerization leading to formation of a double interconnected network of electrically conductive path within the aerogel.
33484804	6	38	theme	PANI	984:987	arg1	inclusion					971:979	inclusion	971:979	inclusion of PANI and nano-clay	971:1001	Thermal stability and storage modulus of the aerogels was improved by inclusion of PANI and nano-clay.
33484804	3	39	theme	in-situ	478:484	arg1	polymerization					486:499	aniline in-situ polymerization	470:499	aniline in-situ polymerization leading to formation of a double interconnected network of electrically conductive path within the aerogel	470:606	Clay nanoplatelets were dispersed in the BC membrane to form a nanofibrillated template for aniline in-situ polymerization leading to formation of a double interconnected network of electrically conductive path within the aerogel.
33484804	8	40	theme	flexibility	1300:1310	arg1	balance					1289:1295	a good balance	1282:1295	a good balance of flexibility, dimensional and thermal stability and biocompatibility	1282:1366	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	5	41	theme	0.49 S/cm	757:765	arg1	conductivity					741:752	The surface electrical conductivity	718:752	The surface electrical conductivity of 0.49 S/cm	718:765	The surface electrical conductivity of 0.49 S/cm was obtained for the composite aerogel comprising 5 wt% nano-clay which is 16 folds higher than that of the sample without nano-clay.
33484804	4	42	theme	XRD	686:688	arg1	techniques					706:715	FTIR, XRD, FESEM, and EDX techniques	680:715	FTIR, XRD, FESEM, and EDX techniques	680:715	Deposition of PANI particles on BC/clay nanocomposite was confirmed by FTIR, XRD, FESEM, and EDX techniques.
33484804	0	43	theme	nanofibrillated	65:79	arg1	template					81:88	nanofibrillated template	65:88	nanofibrillated template of bacterial cellulose/polyaniline/nano-clay	65:133	Electrically conductive biocompatible composite aerogel based on nanofibrillated template of bacterial cellulose/polyaniline/nano-clay.
33484804	8	44	theme	developed	1145:1153	arg1	aerogels					1189:1196	The developed electrically conductive composite aerogels	1141:1196	The developed electrically conductive composite aerogels	1141:1196	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	8	44	theme	developed	1145:1153	arg1	scaffolds					1226:1234	suitable scaffolds	1217:1234	suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility	1217:1366	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	6	45	theme	nano-clay	993:1001	arg1	inclusion					971:979	inclusion	971:979	inclusion of PANI and nano-clay	971:1001	Thermal stability and storage modulus of the aerogels was improved by inclusion of PANI and nano-clay.
33484804	1	46	theme	BC	157:158	arg1	aerogel					161:167	Bacterial cellulose (BC) aerogel	136:167	Bacterial cellulose (BC) aerogel	136:167	Bacterial cellulose (BC) aerogel owing to its porous and 3D structure, poses a suitable matrix for embedding nanomaterials and polymers.
33484804	8	47	theme	good	1284:1287	arg1	balance					1289:1295	a good balance	1282:1295	a good balance of flexibility, dimensional and thermal stability and biocompatibility	1282:1366	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	7	48	from	effect	1016:1021	arg1	adhesion					1076:1083	cell adhesion	1071:1083	cell adhesion	1071:1083	Synergistic effect of clay and polyaniline on biocompatibility and cell adhesion was obtained with no mutagenic or carcinogenic effects.
33484804	7	48	from	effect	1016:1021	arg1	biocompatibility					1050:1065	biocompatibility	1050:1065	biocompatibility	1050:1065	Synergistic effect of clay and polyaniline on biocompatibility and cell adhesion was obtained with no mutagenic or carcinogenic effects.
33484804	2	49	theme	two-step	358:365	arg1	procedure					367:375	a two-step procedure	356:375	a two-step procedure	356:375	Herein, BC composites comprising nano-clay/polyaniline (PANI) were synthesized via a two-step procedure.
33484804	8	50	theme	conductive	1168:1177	arg1	aerogels					1189:1196	The developed electrically conductive composite aerogels	1141:1196	The developed electrically conductive composite aerogels	1141:1196	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	8	50	theme	conductive	1168:1177	arg1	scaffolds					1226:1234	suitable scaffolds	1217:1234	suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility	1217:1366	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	2	51	theme	BC	281:282	arg1	composites					284:293	BC composites	281:293	BC composites comprising nano-clay/polyaniline (PANI)	281:333	Herein, BC composites comprising nano-clay/polyaniline (PANI) were synthesized via a two-step procedure.
33484804	7	52	theme	polyaniline	1035:1045	arg1	effect					1016:1021	Synergistic effect	1004:1021	Synergistic effect of clay and polyaniline on biocompatibility and cell adhesion	1004:1083	Synergistic effect of clay and polyaniline on biocompatibility and cell adhesion was obtained with no mutagenic or carcinogenic effects.
33484804	5	53	theme	surface	722:728	arg1	conductivity					741:752	The surface electrical conductivity	718:752	The surface electrical conductivity of 0.49 S/cm	718:765	The surface electrical conductivity of 0.49 S/cm was obtained for the composite aerogel comprising 5 wt% nano-clay which is 16 folds higher than that of the sample without nano-clay.
33484804	5	54	theme	composite	788:796	arg1	aerogel					798:804	the composite aerogel	784:804	the composite aerogel comprising 5 wt% nano-clay which is 16 folds higher than that of the sample without nano-clay	784:898	The surface electrical conductivity of 0.49 S/cm was obtained for the composite aerogel comprising 5 wt% nano-clay which is 16 folds higher than that of the sample without nano-clay.
33484804	8	55	theme	stability	1337:1345	arg1	balance					1289:1295	a good balance	1282:1295	a good balance of flexibility, dimensional and thermal stability and biocompatibility	1282:1366	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	7	56	theme	clay	1026:1029	arg1	effect					1016:1021	Synergistic effect	1004:1021	Synergistic effect of clay and polyaniline on biocompatibility and cell adhesion	1004:1083	Synergistic effect of clay and polyaniline on biocompatibility and cell adhesion was obtained with no mutagenic or carcinogenic effects.
33484804	4	57	theme	FESEM	691:695	arg1	techniques					706:715	FTIR, XRD, FESEM, and EDX techniques	680:715	FTIR, XRD, FESEM, and EDX techniques	680:715	Deposition of PANI particles on BC/clay nanocomposite was confirmed by FTIR, XRD, FESEM, and EDX techniques.
33484804	8	58	theme	composite	1179:1187	arg1	aerogels					1189:1196	The developed electrically conductive composite aerogels	1141:1196	The developed electrically conductive composite aerogels	1141:1196	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	8	58	theme	composite	1179:1187	arg1	scaffolds					1226:1234	suitable scaffolds	1217:1234	suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility	1217:1366	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	8	59	theme	engineering	1247:1257	arg1	applications					1259:1270	tissue engineering applications	1240:1270	tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility	1240:1366	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33484804	7	60	theme	Synergistic	1004:1014	arg1	effect					1016:1021	Synergistic effect	1004:1021	Synergistic effect of clay and polyaniline on biocompatibility and cell adhesion	1004:1083	Synergistic effect of clay and polyaniline on biocompatibility and cell adhesion was obtained with no mutagenic or carcinogenic effects.
33484804	8	61	theme	tissue	1240:1245	arg1	applications					1259:1270	tissue engineering applications	1240:1270	tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility	1240:1366	The developed electrically conductive composite aerogels can be utilized as suitable scaffolds for tissue engineering applications demanding a good balance of flexibility, dimensional and thermal stability and biocompatibility.
33836194	7	0	theme	LPS-induced	1092:1102	arg1	macrophages					1114:1124	LPS-induced RAW 264.7 macrophages	1092:1124	LPS-induced RAW 264.7 macrophages	1092:1124	Compared to CAOP, AOP expressed better antioxidant activity, and suppressed the NO production in LPS-induced RAW 264.7 macrophages.
33836194	1	1	from	studies	163:169	arg1	pectin					187:192	acid-soluble pectin	174:192	acid-soluble pectin from okra	174:202	Currently, there are few studies on acid-soluble pectin from okra, especially in biological activity for antioxidant and anti-inflammatory.
33836194	3	2	theme	acid-soluble	500:511	arg1	AOP					526:528	AOP	526:528	AOP	526:528	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	2	theme	acid-soluble	500:511	arg1	pectin					518:523	acid-soluble okra pectin	500:523	acid-soluble okra pectin (AOP)	500:529	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	2	theme	acid-soluble	500:511	arg1	fractions					440:448	two acid-soluble okra pectic fractions	411:448	two acid-soluble okra pectic fractions	411:448	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	8	3	theme	resources	1318:1326	arg1	utilization					1298:1308	utilization	1298:1308	utilization	1298:1308	All the above results indicated that AOP had the potential to act as a natural antioxidant or a functional anti-inflammatory food, which would broaden the development and utilization of okra resources.
33836194	8	3	theme	resources	1318:1326	arg1	development					1282:1292	development	1282:1292	development	1282:1292	All the above results indicated that AOP had the potential to act as a natural antioxidant or a functional anti-inflammatory food, which would broaden the development and utilization of okra resources.
33836194	0	4	theme	pectin	92:97	arg1	characterization					13:28	characterization	13:28	characterization	13:28	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	0	4	theme	pectin	92:97	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	0	4	theme	pectin	92:97	arg1	antioxidant					31:41	antioxidant	31:41	antioxidant	31:41	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	0	4	theme	pectin	92:97	arg1	activities					65:74	anti-inflammatory activities	47:74	anti-inflammatory activities	47:74	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	3	5	theme	okra	513:516	arg1	AOP					526:528	AOP	526:528	AOP	526:528	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	5	theme	okra	513:516	arg1	pectin					518:523	acid-soluble okra pectin	500:523	acid-soluble okra pectin (AOP)	500:529	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	5	theme	okra	513:516	arg1	fractions					440:448	two acid-soluble okra pectic fractions	411:448	two acid-soluble okra pectic fractions	411:448	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	4	6	theme	esterification	651:664	arg1	content					713:719	a relatively high uronic acid content	683:719	a relatively high uronic acid content (31.6-37.3%)	683:732	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	4	6	theme	esterification	651:664	arg1	degree					641:646	a low degree	635:646	a low degree of esterification (42.0-46.5%)	635:677	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	4	6	theme	esterification	651:664	arg1	%					676:676	42.0-46.5%	667:676	42.0-46.5%	667:676	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	4	6	theme	esterification	651:664	arg1	%					731:731	31.6-37.3%	722:731	31.6-37.3%	722:731	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	7	7	theme	NO	1075:1076	arg1	production					1078:1087	the NO production	1071:1087	the NO production in LPS-induced RAW 264.7 macrophages	1071:1124	Compared to CAOP, AOP expressed better antioxidant activity, and suppressed the NO production in LPS-induced RAW 264.7 macrophages.
33836194	8	8	theme	natural	1198:1204	arg1	antioxidant					1206:1216	a natural antioxidant	1196:1216	a natural antioxidant	1196:1216	All the above results indicated that AOP had the potential to act as a natural antioxidant or a functional anti-inflammatory food, which would broaden the development and utilization of okra resources.
33836194	0	9	theme	esculentus	122:131	arg1	L					133:133	Abelmoschus esculentus L.	110:134	Abelmoschus esculentus L.	110:134	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	0	9	theme	esculentus	122:131	arg1	okra					104:107	okra	104:107	okra (Abelmoschus esculentus L.)	104:135	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	4	10	theme	high	696:699	arg1	content					713:719	a relatively high uronic acid content	683:719	a relatively high uronic acid content (31.6-37.3%)	683:732	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	4	10	theme	high	696:699	arg1	%					731:731	31.6-37.3%	722:731	31.6-37.3%	722:731	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	6	11	theme	components	960:969	arg1	properties					921:930	Morphological and thermal properties	895:930	Morphological and thermal properties of acid-soluble okra pectin components	895:969	Morphological and thermal properties of acid-soluble okra pectin components were also investigated.
33836194	8	12	theme	functional	1223:1232	arg1	food					1252:1255	a functional anti-inflammatory food	1221:1255	a functional anti-inflammatory food	1221:1255	All the above results indicated that AOP had the potential to act as a natural antioxidant or a functional anti-inflammatory food, which would broaden the development and utilization of okra resources.
33836194	6	13	theme	okra	948:951	arg1	components					960:969	acid-soluble okra pectin components	935:969	acid-soluble okra pectin components	935:969	Morphological and thermal properties of acid-soluble okra pectin components were also investigated.
33836194	1	14	theme	few	159:161	arg1	studies					163:169	few studies	159:169	few studies on acid-soluble pectin from okra	159:202	Currently, there are few studies on acid-soluble pectin from okra, especially in biological activity for antioxidant and anti-inflammatory.
33836194	0	15	theme	Abelmoschus	110:120	arg1	L					133:133	Abelmoschus esculentus L.	110:134	Abelmoschus esculentus L.	110:134	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	0	15	theme	Abelmoschus	110:120	arg1	okra					104:107	okra	104:107	okra (Abelmoschus esculentus L.)	104:135	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	7	16	theme	better	1027:1032	arg1	activity					1046:1053	better antioxidant activity	1027:1053	better antioxidant activity	1027:1053	Compared to CAOP, AOP expressed better antioxidant activity, and suppressed the NO production in LPS-induced RAW 264.7 macrophages.
33836194	5	17	theme	mol/	802:805	arg1	galactose					787:795	galactose	787:795	galactose (4.3 mol/%)	787:807	AOP was composed of galacturonic acid (79.1 mol/%), galactose (4.3 mol/%), rhamnose (14.5 mol/%) and xylose (2.1 mol/%), and the molecular weight was 92.8 kDa.
33836194	5	17	theme	mol/	802:805	arg1	%					806:806	4.3 mol/%	798:806	4.3 mol/%	798:806	AOP was composed of galacturonic acid (79.1 mol/%), galactose (4.3 mol/%), rhamnose (14.5 mol/%) and xylose (2.1 mol/%), and the molecular weight was 92.8 kDa.
33836194	7	18	theme	RAW	1104:1106	arg1	macrophages					1114:1124	LPS-induced RAW 264.7 macrophages	1092:1124	LPS-induced RAW 264.7 macrophages	1092:1124	Compared to CAOP, AOP expressed better antioxidant activity, and suppressed the NO production in LPS-induced RAW 264.7 macrophages.
33836194	3	19	theme	pectic	433:438	arg1	pectin					518:523	acid-soluble okra pectin	500:523	acid-soluble okra pectin (AOP)	500:529	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	19	theme	pectic	433:438	arg1	fractions					440:448	two acid-soluble okra pectic fractions	411:448	two acid-soluble okra pectic fractions	411:448	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	19	theme	pectic	433:438	arg1	pectin					482:487	crude acid-soluble okra pectin	458:487	crude acid-soluble okra pectin (CAOP)	458:494	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	2	20	theme	antioxidant	297:307	arg1	properties					309:318	the antioxidant properties	293:318	the antioxidant properties of acid-soluble okra pectin components and their anti-inflammatory	293:385	In this study, the antioxidant properties of acid-soluble okra pectin components and their anti-inflammatory were explored.
33836194	1	21	theme	acid-soluble	174:185	arg1	pectin					187:192	acid-soluble pectin	174:192	acid-soluble pectin from okra	174:202	Currently, there are few studies on acid-soluble pectin from okra, especially in biological activity for antioxidant and anti-inflammatory.
33836194	5	22	theme	mol/	779:782	arg1	acid					768:771	galacturonic acid	755:771	galacturonic acid (79.1 mol/%)	755:784	AOP was composed of galacturonic acid (79.1 mol/%), galactose (4.3 mol/%), rhamnose (14.5 mol/%) and xylose (2.1 mol/%), and the molecular weight was 92.8 kDa.
33836194	5	22	theme	mol/	779:782	arg1	%					783:783	79.1 mol/%	774:783	79.1 mol/%	774:783	AOP was composed of galacturonic acid (79.1 mol/%), galactose (4.3 mol/%), rhamnose (14.5 mol/%) and xylose (2.1 mol/%), and the molecular weight was 92.8 kDa.
33836194	5	23	theme	mol/	848:851	arg1	xylose					836:841	xylose	836:841	xylose (2.1 mol/%)	836:853	AOP was composed of galacturonic acid (79.1 mol/%), galactose (4.3 mol/%), rhamnose (14.5 mol/%) and xylose (2.1 mol/%), and the molecular weight was 92.8 kDa.
33836194	5	23	theme	mol/	848:851	arg1	%					852:852	2.1 mol/%	844:852	2.1 mol/%	844:852	AOP was composed of galacturonic acid (79.1 mol/%), galactose (4.3 mol/%), rhamnose (14.5 mol/%) and xylose (2.1 mol/%), and the molecular weight was 92.8 kDa.
33836194	3	24	theme	okra	477:480	arg1	CAOP					490:493	CAOP	490:493	CAOP	490:493	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	24	theme	okra	477:480	arg1	fractions					440:448	two acid-soluble okra pectic fractions	411:448	two acid-soluble okra pectic fractions	411:448	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	24	theme	okra	477:480	arg1	pectin					482:487	crude acid-soluble okra pectin	458:487	crude acid-soluble okra pectin (CAOP)	458:494	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	25	theme	structural	560:569	arg1	variation					589:597	structural and compositional variation	560:597	structural and compositional variation	560:597	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	2	26	theme	components	348:357	arg1	properties					309:318	the antioxidant properties	293:318	the antioxidant properties of acid-soluble okra pectin components and their anti-inflammatory	293:385	In this study, the antioxidant properties of acid-soluble okra pectin components and their anti-inflammatory were explored.
33836194	8	27	dep	development	1282:1292	arg1	the					1278:1280	the	1278:1280	the	1278:1280	All the above results indicated that AOP had the potential to act as a natural antioxidant or a functional anti-inflammatory food, which would broaden the development and utilization of okra resources.
33836194	3	28	theme	acid-soluble	415:426	arg1	pectin					518:523	acid-soluble okra pectin	500:523	acid-soluble okra pectin (AOP)	500:529	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	28	theme	acid-soluble	415:426	arg1	fractions					440:448	two acid-soluble okra pectic fractions	411:448	two acid-soluble okra pectic fractions	411:448	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	28	theme	acid-soluble	415:426	arg1	pectin					482:487	crude acid-soluble okra pectin	458:487	crude acid-soluble okra pectin (CAOP)	458:494	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	6	29	theme	thermal	913:919	arg1	properties					921:930	Morphological and thermal properties	895:930	Morphological and thermal properties of acid-soluble okra pectin components	895:969	Morphological and thermal properties of acid-soluble okra pectin components were also investigated.
33836194	4	30	theme	low	637:639	arg1	%					676:676	42.0-46.5%	667:676	42.0-46.5%	667:676	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	4	30	theme	low	637:639	arg1	degree					641:646	a low degree	635:646	a low degree of esterification (42.0-46.5%)	635:677	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	6	31	theme	acid-soluble	935:946	arg1	components					960:969	acid-soluble okra pectin components	935:969	acid-soluble okra pectin components	935:969	Morphological and thermal properties of acid-soluble okra pectin components were also investigated.
33836194	3	32	theme	crude	458:462	arg1	CAOP					490:493	CAOP	490:493	CAOP	490:493	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	32	theme	crude	458:462	arg1	fractions					440:448	two acid-soluble okra pectic fractions	411:448	two acid-soluble okra pectic fractions	411:448	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	32	theme	crude	458:462	arg1	pectin					482:487	crude acid-soluble okra pectin	458:487	crude acid-soluble okra pectin (CAOP)	458:494	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	33	theme	okra	428:431	arg1	pectin					518:523	acid-soluble okra pectin	500:523	acid-soluble okra pectin (AOP)	500:529	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	33	theme	okra	428:431	arg1	fractions					440:448	two acid-soluble okra pectic fractions	411:448	two acid-soluble okra pectic fractions	411:448	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	33	theme	okra	428:431	arg1	pectin					482:487	crude acid-soluble okra pectin	458:487	crude acid-soluble okra pectin (CAOP)	458:494	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	7	34	theme	antioxidant	1034:1044	arg1	activity					1046:1053	better antioxidant activity	1027:1053	better antioxidant activity	1027:1053	Compared to CAOP, AOP expressed better antioxidant activity, and suppressed the NO production in LPS-induced RAW 264.7 macrophages.
33836194	4	35	contain	contained	625:633	arg2	content					713:719	a relatively high uronic acid content	683:719	a relatively high uronic acid content (31.6-37.3%)	683:732	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	4	35	contain	contained	625:633	arg2	%					676:676	42.0-46.5%	667:676	42.0-46.5%	667:676	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	4	35	contain	contained	625:633	arg2	%					731:731	31.6-37.3%	722:731	31.6-37.3%	722:731	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	4	35	contain	contained	625:633	arg2	degree					641:646	a low degree	635:646	a low degree of esterification (42.0-46.5%)	635:677	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	4	35	contain	contained	625:633	arg1	fractions					615:623	The two pectic fractions	600:623	The two pectic fractions	600:623	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	1	36	from	okra	199:202	arg1	pectin					187:192	acid-soluble pectin	174:192	acid-soluble pectin from okra	174:202	Currently, there are few studies on acid-soluble pectin from okra, especially in biological activity for antioxidant and anti-inflammatory.
33836194	3	37	theme	acid-soluble	464:475	arg1	CAOP					490:493	CAOP	490:493	CAOP	490:493	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	37	theme	acid-soluble	464:475	arg1	fractions					440:448	two acid-soluble okra pectic fractions	411:448	two acid-soluble okra pectic fractions	411:448	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	3	37	theme	acid-soluble	464:475	arg1	pectin					482:487	crude acid-soluble okra pectin	458:487	crude acid-soluble okra pectin (CAOP)	458:494	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	5	38	theme	galacturonic	755:766	arg1	acid					768:771	galacturonic acid	755:771	galacturonic acid (79.1 mol/%)	755:784	AOP was composed of galacturonic acid (79.1 mol/%), galactose (4.3 mol/%), rhamnose (14.5 mol/%) and xylose (2.1 mol/%), and the molecular weight was 92.8 kDa.
33836194	5	38	theme	galacturonic	755:766	arg1	%					783:783	79.1 mol/%	774:783	79.1 mol/%	774:783	AOP was composed of galacturonic acid (79.1 mol/%), galactose (4.3 mol/%), rhamnose (14.5 mol/%) and xylose (2.1 mol/%), and the molecular weight was 92.8 kDa.
33836194	8	39	theme	anti-inflammatory	1234:1250	arg1	food					1252:1255	a functional anti-inflammatory food	1221:1255	a functional anti-inflammatory food	1221:1255	All the above results indicated that AOP had the potential to act as a natural antioxidant or a functional anti-inflammatory food, which would broaden the development and utilization of okra resources.
33836194	2	40	theme	pectin	341:346	arg1	components					348:357	acid-soluble okra pectin components	323:357	acid-soluble okra pectin components	323:357	In this study, the antioxidant properties of acid-soluble okra pectin components and their anti-inflammatory were explored.
33836194	0	41	theme	anti-inflammatory	47:63	arg1	activities					65:74	anti-inflammatory activities	47:74	anti-inflammatory activities	47:74	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	3	42	theme	compositional	575:587	arg1	variation					589:597	structural and compositional variation	560:597	structural and compositional variation	560:597	Firstly, two acid-soluble okra pectic fractions, namely crude acid-soluble okra pectin (CAOP) and acid-soluble okra pectin (AOP), were obtained and exhibited structural and compositional variation.
33836194	2	43	theme	okra	336:339	arg1	components					348:357	acid-soluble okra pectin components	323:357	acid-soluble okra pectin components	323:357	In this study, the antioxidant properties of acid-soluble okra pectin components and their anti-inflammatory were explored.
33836194	8	44	contain	had	1168:1170	arg2	potential					1176:1184	the potential to act as a natural antioxidant or a functional anti-inflammatory food, which would broaden the development and utilization of okra resources	1172:1326	the potential to act as a natural antioxidant or a functional anti-inflammatory food, which would broaden the development and utilization of okra resources	1172:1326	All the above results indicated that AOP had the potential to act as a natural antioxidant or a functional anti-inflammatory food, which would broaden the development and utilization of okra resources.
33836194	8	44	contain	had	1168:1170	arg1	AOP					1164:1166	AOP	1164:1166	AOP	1164:1166	All the above results indicated that AOP had the potential to act as a natural antioxidant or a functional anti-inflammatory food, which would broaden the development and utilization of okra resources.
33836194	8	45	theme	above	1135:1139	arg1	results					1141:1147	All the above results	1127:1147	All the above results	1127:1147	All the above results indicated that AOP had the potential to act as a natural antioxidant or a functional anti-inflammatory food, which would broaden the development and utilization of okra resources.
33836194	2	46	theme	acid-soluble	323:334	arg1	components					348:357	acid-soluble okra pectin components	323:357	acid-soluble okra pectin components	323:357	In this study, the antioxidant properties of acid-soluble okra pectin components and their anti-inflammatory were explored.
33836194	6	47	theme	Morphological	895:907	arg1	properties					921:930	Morphological and thermal properties	895:930	Morphological and thermal properties of acid-soluble okra pectin components	895:969	Morphological and thermal properties of acid-soluble okra pectin components were also investigated.
33836194	7	48	from	production	1078:1087	arg1	macrophages					1114:1124	LPS-induced RAW 264.7 macrophages	1092:1124	LPS-induced RAW 264.7 macrophages	1092:1124	Compared to CAOP, AOP expressed better antioxidant activity, and suppressed the NO production in LPS-induced RAW 264.7 macrophages.
33836194	5	49	theme	mol/	825:828	arg1	%					829:829	14.5 mol/%	820:829	14.5 mol/%	820:829	AOP was composed of galacturonic acid (79.1 mol/%), galactose (4.3 mol/%), rhamnose (14.5 mol/%) and xylose (2.1 mol/%), and the molecular weight was 92.8 kDa.
33836194	5	49	theme	mol/	825:828	arg1	rhamnose					810:817	rhamnose	810:817	rhamnose (14.5 mol/%)	810:830	AOP was composed of galacturonic acid (79.1 mol/%), galactose (4.3 mol/%), rhamnose (14.5 mol/%) and xylose (2.1 mol/%), and the molecular weight was 92.8 kDa.
33836194	5	50	theme	molecular	864:872	arg1	weight					874:879	the molecular weight	860:879	the molecular weight	860:879	AOP was composed of galacturonic acid (79.1 mol/%), galactose (4.3 mol/%), rhamnose (14.5 mol/%) and xylose (2.1 mol/%), and the molecular weight was 92.8 kDa.
33836194	5	50	theme	molecular	864:872	arg1	kDa					890:892	92.8 kDa	885:892	92.8 kDa	885:892	AOP was composed of galacturonic acid (79.1 mol/%), galactose (4.3 mol/%), rhamnose (14.5 mol/%) and xylose (2.1 mol/%), and the molecular weight was 92.8 kDa.
33836194	4	51	theme	uronic	701:706	arg1	content					713:719	a relatively high uronic acid content	683:719	a relatively high uronic acid content (31.6-37.3%)	683:732	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	4	51	theme	uronic	701:706	arg1	%					731:731	31.6-37.3%	722:731	31.6-37.3%	722:731	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	4	52	theme	acid	708:711	arg1	content					713:719	a relatively high uronic acid content	683:719	a relatively high uronic acid content (31.6-37.3%)	683:732	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	4	52	theme	acid	708:711	arg1	%					731:731	31.6-37.3%	722:731	31.6-37.3%	722:731	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
33836194	0	53	theme	acid-soluble	79:90	arg1	pectin					92:97	acid-soluble pectin	79:97	acid-soluble pectin	79:97	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	0	54	from	okra	104:107	arg1	characterization					13:28	characterization	13:28	characterization	13:28	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	0	54	from	okra	104:107	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	0	54	from	okra	104:107	arg1	antioxidant					31:41	antioxidant	31:41	antioxidant	31:41	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	0	54	from	okra	104:107	arg1	activities					65:74	anti-inflammatory activities	47:74	anti-inflammatory activities	47:74	Preparation, characterization, antioxidant and anti-inflammatory activities of acid-soluble pectin from okra (Abelmoschus esculentus L.).
33836194	8	55	theme	okra	1313:1316	arg1	resources					1318:1326	okra resources	1313:1326	okra resources	1313:1326	All the above results indicated that AOP had the potential to act as a natural antioxidant or a functional anti-inflammatory food, which would broaden the development and utilization of okra resources.
33836194	2	56	theme	anti-inflammatory	369:385	arg1	properties					309:318	the antioxidant properties	293:318	the antioxidant properties of acid-soluble okra pectin components and their anti-inflammatory	293:385	In this study, the antioxidant properties of acid-soluble okra pectin components and their anti-inflammatory were explored.
33836194	6	57	theme	pectin	953:958	arg1	components					960:969	acid-soluble okra pectin components	935:969	acid-soluble okra pectin components	935:969	Morphological and thermal properties of acid-soluble okra pectin components were also investigated.
33836194	1	58	theme	biological	219:228	arg1	activity					230:237	biological activity	219:237	biological activity for antioxidant and anti-inflammatory	219:275	Currently, there are few studies on acid-soluble pectin from okra, especially in biological activity for antioxidant and anti-inflammatory.
33836194	4	59	theme	pectic	608:613	arg1	fractions					615:623	The two pectic fractions	600:623	The two pectic fractions	600:623	The two pectic fractions contained a low degree of esterification (42.0-46.5%) and a relatively high uronic acid content (31.6-37.3%).
32003648	7	0	theme	Langmuir	1141:1148	arg1	fitting					1156:1162	the Langmuir model fitting	1137:1162	the Langmuir model fitting	1137:1162	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	9	1	from	solutions	1634:1642	arg1	removal					1596:1602	removal	1596:1602	removal of cationic dyes from aqueous solutions	1596:1642	All of these results illustrate that MCT has great potential for practical application in removal of cationic dyes from aqueous solutions.
32003648	9	1	from	solutions	1634:1642	arg1	application					1581:1591	practical application	1571:1591	practical application in removal of cationic dyes from aqueous solutions	1571:1642	All of these results illustrate that MCT has great potential for practical application in removal of cationic dyes from aqueous solutions.
32003648	5	2	theme	dyes	850:853	arg1	properties					827:836	The adsorption properties	812:836	The adsorption properties of cationic dyes by MCT	812:860	The adsorption properties of cationic dyes by MCT were further investigated by using methylene blue (MB) as a representative.
32003648	7	3	theme	model	1150:1154	arg1	fitting					1156:1162	the Langmuir model fitting	1137:1162	the Langmuir model fitting	1137:1162	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	3	4	contain	have	492:495	arg1	peaks					445:449	the characteristic peaks	426:449	the characteristic peaks of the SO3-group on MCT	426:473	According to the FTIR spectrum of MCT, the characteristic peaks of the SO3-group on MCT were observed to have a shift after adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye.
32003648	3	4	contain	have	492:495	arg2	shift					499:503	a shift	497:503	a shift	497:503	According to the FTIR spectrum of MCT, the characteristic peaks of the SO3-group on MCT were observed to have a shift after adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye.
32003648	1	5	theme	adsorbent	163:171	arg1	taurine					155:161	A novel magnetic Fe3O4@chitosan@taurine adsorbent	123:171	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT)	123:177	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	1	5	theme	adsorbent	163:171	arg1	MCT					174:176	MCT	174:176	MCT	174:176	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	1	6	theme	taurine-glutaraldehyde	258:279	arg1	solution					281:288	taurine-glutaraldehyde solution	258:288	taurine-glutaraldehyde solution	258:288	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	0	7	theme	blue	117:120	arg1	methylene					107:115	methylene blue	107:120	methylene blue	107:120	Facile preparation of taurine modified magnetic chitosan nanocomposites as biodegradable adsorbents toward methylene blue.
32003648	7	8	theme	adsorption	1237:1246	arg1	equilibrium					1248:1258	the adsorption equilibrium	1233:1258	the adsorption equilibrium	1233:1258	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	9	9	theme	great	1551:1555	arg1	potential					1557:1565	great potential	1551:1565	great potential for practical application in removal of cationic dyes from aqueous solutions	1551:1642	All of these results illustrate that MCT has great potential for practical application in removal of cationic dyes from aqueous solutions.
32003648	5	10	theme	cationic	841:848	arg1	dyes					850:853	cationic dyes	841:853	cationic dyes	841:853	The adsorption properties of cationic dyes by MCT were further investigated by using methylene blue (MB) as a representative.
32003648	9	11	theme	practical	1571:1579	arg1	application					1581:1591	practical application	1571:1591	practical application in removal of cationic dyes from aqueous solutions	1571:1642	All of these results illustrate that MCT has great potential for practical application in removal of cationic dyes from aqueous solutions.
32003648	7	12	from	pH	1184:1185	arg1	384.6 mg g-1					1193:1204	384.6 mg g-1	1193:1204	384.6 mg g-1 at pH 9	1193:1212	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	7	12	from	pH	1184:1185	arg1	204.1 mg g-1					1168:1179	204.1 mg g-1	1168:1179	204.1 mg g-1 at pH 5	1168:1187	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	7	12	from	pH	1184:1185	arg1	capacity					1106:1113	The maximum adsorption capacity	1083:1113	The maximum adsorption capacity of MB calculated from the Langmuir model fitting	1083:1162	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	1	13	mod	modification	203:214	arg1	nano-composites					237:251	magnetic chitosan nano-composites	219:251	magnetic chitosan nano-composites with taurine-glutaraldehyde solution	219:288	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	1	13	mod	modification	203:214	arg3	surface					195:201	surface modification	195:214	surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution	195:288	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	3	14	theme	SO3-group	458:466	arg1	peaks					445:449	the characteristic peaks	426:449	the characteristic peaks of the SO3-group on MCT	426:473	According to the FTIR spectrum of MCT, the characteristic peaks of the SO3-group on MCT were observed to have a shift after adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye.
32003648	7	15	theme	MB	1118:1119	arg1	204.1 mg g-1					1168:1179	204.1 mg g-1	1168:1179	204.1 mg g-1 at pH 5	1168:1187	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	7	15	theme	MB	1118:1119	arg1	capacity					1106:1113	The maximum adsorption capacity	1083:1113	The maximum adsorption capacity of MB calculated from the Langmuir model fitting	1083:1162	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	6	16	theme	kinetic	1022:1028	arg1	model					1030:1034	the pseudo-second order kinetic model	998:1034	the pseudo-second order kinetic model	998:1034	The adsorption behaviour of MB by MCT was well described by the pseudo-second order kinetic model and the Langmuir isotherm model, respectively.
32003648	6	17	theme	pseudo-second	1002:1014	arg1	model					1030:1034	the pseudo-second order kinetic model	998:1034	the pseudo-second order kinetic model	998:1034	The adsorption behaviour of MB by MCT was well described by the pseudo-second order kinetic model and the Langmuir isotherm model, respectively.
32003648	9	18	contain	has	1547:1549	arg1	MCT					1543:1545	MCT	1543:1545	MCT	1543:1545	All of these results illustrate that MCT has great potential for practical application in removal of cationic dyes from aqueous solutions.
32003648	9	18	contain	has	1547:1549	arg2	potential					1557:1565	great potential	1551:1565	great potential for practical application in removal of cationic dyes from aqueous solutions	1551:1642	All of these results illustrate that MCT has great potential for practical application in removal of cationic dyes from aqueous solutions.
32003648	3	19	theme	MCT	421:423	arg1	spectrum					409:416	the FTIR spectrum	400:416	the FTIR spectrum of MCT	400:423	According to the FTIR spectrum of MCT, the characteristic peaks of the SO3-group on MCT were observed to have a shift after adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye.
32003648	6	20	theme	Langmuir	1044:1051	arg1	model					1062:1066	the Langmuir isotherm model	1040:1066	the Langmuir isotherm model	1040:1066	The adsorption behaviour of MB by MCT was well described by the pseudo-second order kinetic model and the Langmuir isotherm model, respectively.
32003648	6	21	theme	order	1016:1020	arg1	model					1030:1034	the pseudo-second order kinetic model	998:1034	the pseudo-second order kinetic model	998:1034	The adsorption behaviour of MB by MCT was well described by the pseudo-second order kinetic model and the Langmuir isotherm model, respectively.
32003648	4	22	dep	sufficient	742:751	arg1	meet					774:777	meet	774:777	to meet the need of magnetic separation	771:809	Moreover, the saturation magnetization of MCT was found to be 20.797 emu g-1, suggesting that MCT has sufficient magnetic response to meet the need of magnetic separation.
32003648	8	23	theme	ΔG°	1324:1326	arg1	values					1314:1319	the negative values	1301:1319	the negative values of ΔG° and ΔH°	1301:1334	Besides, the negative values of ΔG° and ΔH° suggested that the adsorption process was spontaneous and exothermic, and the good reusability indicated that MCT could act as a recyclable adsorbent for dye adsorption.
32003648	4	24	theme	separation	800:809	arg1	need					783:786	the need	779:786	the need of magnetic separation	779:809	Moreover, the saturation magnetization of MCT was found to be 20.797 emu g-1, suggesting that MCT has sufficient magnetic response to meet the need of magnetic separation.
32003648	3	25	from	SO3-group	458:466	arg1	MCT					471:473	MCT	471:473	MCT	471:473	According to the FTIR spectrum of MCT, the characteristic peaks of the SO3-group on MCT were observed to have a shift after adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye.
32003648	3	26	theme	cationic	529:536	arg1	dye					538:540	the cationic dye	525:540	the cationic dye	525:540	According to the FTIR spectrum of MCT, the characteristic peaks of the SO3-group on MCT were observed to have a shift after adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye.
32003648	5	27	theme	adsorption	816:825	arg1	properties					827:836	The adsorption properties	812:836	The adsorption properties of cationic dyes by MCT	812:860	The adsorption properties of cationic dyes by MCT were further investigated by using methylene blue (MB) as a representative.
32003648	0	28	theme	Facile	0:5	arg1	preparation					7:17	Facile preparation	0:17	Facile preparation of taurine	0:28	Facile preparation of taurine modified magnetic chitosan nanocomposites as biodegradable adsorbents toward methylene blue.
32003648	9	29	from	application	1581:1591	arg1	removal					1596:1602	removal	1596:1602	removal of cationic dyes from aqueous solutions	1596:1642	All of these results illustrate that MCT has great potential for practical application in removal of cationic dyes from aqueous solutions.
32003648	9	29	from	application	1581:1591	arg1	solutions					1634:1642	aqueous solutions	1626:1642	aqueous solutions	1626:1642	All of these results illustrate that MCT has great potential for practical application in removal of cationic dyes from aqueous solutions.
32003648	4	30	theme	magnetic	791:798	arg1	separation					800:809	magnetic separation	791:809	magnetic separation	791:809	Moreover, the saturation magnetization of MCT was found to be 20.797 emu g-1, suggesting that MCT has sufficient magnetic response to meet the need of magnetic separation.
32003648	3	31	theme	dye	538:540	arg1	adsorption					511:520	adsorption	511:520	adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye	511:637	According to the FTIR spectrum of MCT, the characteristic peaks of the SO3-group on MCT were observed to have a shift after adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye.
32003648	0	32	theme	taurine	22:28	arg1	preparation					7:17	Facile preparation	0:17	Facile preparation of taurine	0:28	Facile preparation of taurine modified magnetic chitosan nanocomposites as biodegradable adsorbents toward methylene blue.
32003648	3	33	from	MCT	471:473	arg1	peaks					445:449	the characteristic peaks	426:449	the characteristic peaks of the SO3-group on MCT	426:473	According to the FTIR spectrum of MCT, the characteristic peaks of the SO3-group on MCT were observed to have a shift after adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye.
32003648	7	34	theme	adsorption	1095:1104	arg1	204.1 mg g-1					1168:1179	204.1 mg g-1	1168:1179	204.1 mg g-1 at pH 5	1168:1187	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	7	34	theme	adsorption	1095:1104	arg1	capacity					1106:1113	The maximum adsorption capacity	1083:1113	The maximum adsorption capacity of MB calculated from the Langmuir model fitting	1083:1162	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	5	35	theme	blue	907:910	arg1	methylene					897:905	methylene blue	897:910	methylene blue (MB)	897:915	The adsorption properties of cationic dyes by MCT were further investigated by using methylene blue (MB) as a representative.
32003648	5	35	theme	blue	907:910	arg1	MB					913:914	MB	913:914	MB	913:914	The adsorption properties of cationic dyes by MCT were further investigated by using methylene blue (MB) as a representative.
32003648	5	35	theme	blue	907:910	arg1	representative					922:935	a representative	920:935	a representative	920:935	The adsorption properties of cationic dyes by MCT were further investigated by using methylene blue (MB) as a representative.
32003648	2	36	theme	VSM	357:359	arg1	FTIR					328:331	FTIR	328:331	FTIR	328:331	The adsorbents were characterized by FTIR, SEM, TEM, XRD, TGA and VSM techniques, respectively.
32003648	2	36	theme	VSM	357:359	arg1	techniques					361:370	VSM techniques	357:370	VSM techniques	357:370	The adsorbents were characterized by FTIR, SEM, TEM, XRD, TGA and VSM techniques, respectively.
32003648	0	37	theme	magnetic	39:46	arg1	nanocomposites					57:70	magnetic chitosan nanocomposites	39:70	magnetic chitosan nanocomposites as biodegradable adsorbents toward methylene blue	39:120	Facile preparation of taurine modified magnetic chitosan nanocomposites as biodegradable adsorbents toward methylene blue.
32003648	4	38	theme	saturation	654:663	arg1	magnetization					665:677	the saturation magnetization	650:677	the saturation magnetization of MCT	650:684	Moreover, the saturation magnetization of MCT was found to be 20.797 emu g-1, suggesting that MCT has sufficient magnetic response to meet the need of magnetic separation.
32003648	4	38	theme	saturation	654:663	arg1	20.797 emu g-1					702:715	20.797 emu g-1	702:715	20.797 emu g-1	702:715	Moreover, the saturation magnetization of MCT was found to be 20.797 emu g-1, suggesting that MCT has sufficient magnetic response to meet the need of magnetic separation.
32003648	9	39	theme	cationic	1607:1614	arg1	dyes					1616:1619	cationic dyes	1607:1619	cationic dyes	1607:1619	All of these results illustrate that MCT has great potential for practical application in removal of cationic dyes from aqueous solutions.
32003648	6	40	theme	isotherm	1053:1060	arg1	model					1062:1066	the Langmuir isotherm model	1040:1066	the Langmuir isotherm model	1040:1066	The adsorption behaviour of MB by MCT was well described by the pseudo-second order kinetic model and the Langmuir isotherm model, respectively.
32003648	8	41	theme	negative	1305:1312	arg1	values					1314:1319	the negative values	1301:1319	the negative values of ΔG° and ΔH°	1301:1334	Besides, the negative values of ΔG° and ΔH° suggested that the adsorption process was spontaneous and exothermic, and the good reusability indicated that MCT could act as a recyclable adsorbent for dye adsorption.
32003648	1	42	theme	surface	195:201	arg1	modification					203:214	surface modification	195:214	surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution	195:288	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	3	43	theme	FTIR	404:407	arg1	spectrum					409:416	the FTIR spectrum	400:416	the FTIR spectrum of MCT	400:423	According to the FTIR spectrum of MCT, the characteristic peaks of the SO3-group on MCT were observed to have a shift after adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye.
32003648	9	44	theme	dyes	1616:1619	arg1	removal					1596:1602	removal	1596:1602	removal of cationic dyes from aqueous solutions	1596:1642	All of these results illustrate that MCT has great potential for practical application in removal of cationic dyes from aqueous solutions.
32003648	7	45	theme	maximum	1087:1093	arg1	204.1 mg g-1					1168:1179	204.1 mg g-1	1168:1179	204.1 mg g-1 at pH 5	1168:1187	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	7	45	theme	maximum	1087:1093	arg1	capacity					1106:1113	The maximum adsorption capacity	1083:1113	The maximum adsorption capacity of MB calculated from the Langmuir model fitting	1083:1162	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	3	46	theme	characteristic	430:443	arg1	peaks					445:449	the characteristic peaks	426:449	the characteristic peaks of the SO3-group on MCT	426:473	According to the FTIR spectrum of MCT, the characteristic peaks of the SO3-group on MCT were observed to have a shift after adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye.
32003648	8	47	theme	adsorption	1355:1364	arg1	spontaneous					1378:1388	spontaneous	1378:1388	spontaneous	1378:1388	Besides, the negative values of ΔG° and ΔH° suggested that the adsorption process was spontaneous and exothermic, and the good reusability indicated that MCT could act as a recyclable adsorbent for dye adsorption.
32003648	8	47	theme	adsorption	1355:1364	arg1	process					1366:1372	the adsorption process	1351:1372	the adsorption process	1351:1372	Besides, the negative values of ΔG° and ΔH° suggested that the adsorption process was spontaneous and exothermic, and the good reusability indicated that MCT could act as a recyclable adsorbent for dye adsorption.
32003648	1	48	theme	novel	125:129	arg1	taurine					155:161	A novel magnetic Fe3O4@chitosan@taurine adsorbent	123:171	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT)	123:177	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	1	48	theme	novel	125:129	arg1	MCT					174:176	MCT	174:176	MCT	174:176	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	0	49	theme	chitosan	48:55	arg1	nanocomposites					57:70	magnetic chitosan nanocomposites	39:70	magnetic chitosan nanocomposites as biodegradable adsorbents toward methylene blue	39:120	Facile preparation of taurine modified magnetic chitosan nanocomposites as biodegradable adsorbents toward methylene blue.
32003648	8	50	theme	dye	1490:1492	arg1	adsorption					1494:1503	dye adsorption	1490:1503	dye adsorption	1490:1503	Besides, the negative values of ΔG° and ΔH° suggested that the adsorption process was spontaneous and exothermic, and the good reusability indicated that MCT could act as a recyclable adsorbent for dye adsorption.
32003648	9	51	theme	aqueous	1626:1632	arg1	solutions					1634:1642	aqueous solutions	1626:1642	aqueous solutions	1626:1642	All of these results illustrate that MCT has great potential for practical application in removal of cationic dyes from aqueous solutions.
32003648	3	52	theme	cationic	626:633	arg1	dye					635:637	the cationic dye	622:637	the cationic dye	622:637	According to the FTIR spectrum of MCT, the characteristic peaks of the SO3-group on MCT were observed to have a shift after adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye.
32003648	8	53	theme	ΔH°	1332:1334	arg1	values					1314:1319	the negative values	1301:1319	the negative values of ΔG° and ΔH°	1301:1334	Besides, the negative values of ΔG° and ΔH° suggested that the adsorption process was spontaneous and exothermic, and the good reusability indicated that MCT could act as a recyclable adsorbent for dye adsorption.
32003648	3	54	from	peaks	445:449	arg1	MCT					471:473	MCT	471:473	MCT	471:473	According to the FTIR spectrum of MCT, the characteristic peaks of the SO3-group on MCT were observed to have a shift after adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye.
32003648	1	55	theme	magnetic	131:138	arg1	taurine					155:161	A novel magnetic Fe3O4@chitosan@taurine adsorbent	123:171	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT)	123:177	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	1	55	theme	magnetic	131:138	arg1	MCT					174:176	MCT	174:176	MCT	174:176	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	4	56	theme	MCT	682:684	arg1	magnetization					665:677	the saturation magnetization	650:677	the saturation magnetization of MCT	650:684	Moreover, the saturation magnetization of MCT was found to be 20.797 emu g-1, suggesting that MCT has sufficient magnetic response to meet the need of magnetic separation.
32003648	4	56	theme	MCT	682:684	arg1	20.797 emu g-1					702:715	20.797 emu g-1	702:715	20.797 emu g-1	702:715	Moreover, the saturation magnetization of MCT was found to be 20.797 emu g-1, suggesting that MCT has sufficient magnetic response to meet the need of magnetic separation.
32003648	7	57	from	pH	1209:1210	arg1	384.6 mg g-1					1193:1204	384.6 mg g-1	1193:1204	384.6 mg g-1 at pH 9	1193:1212	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	7	57	from	pH	1209:1210	arg1	204.1 mg g-1					1168:1179	204.1 mg g-1	1168:1179	204.1 mg g-1 at pH 5	1168:1187	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	7	57	from	pH	1209:1210	arg1	capacity					1106:1113	The maximum adsorption capacity	1083:1113	The maximum adsorption capacity of MB calculated from the Langmuir model fitting	1083:1162	The maximum adsorption capacity of MB calculated from the Langmuir model fitting was 204.1 mg g-1 at pH 5 and 384.6 mg g-1 at pH 9, respectively, and the adsorption equilibrium could be reached within 10 min.
32003648	1	58	theme	Fe3O4	140:144	arg1	taurine					155:161	A novel magnetic Fe3O4@chitosan@taurine adsorbent	123:171	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT)	123:177	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	1	58	theme	Fe3O4	140:144	arg1	MCT					174:176	MCT	174:176	MCT	174:176	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	6	59	theme	MB	966:967	arg1	behaviour					953:961	The adsorption behaviour	938:961	The adsorption behaviour of MB by MCT	938:974	The adsorption behaviour of MB by MCT was well described by the pseudo-second order kinetic model and the Langmuir isotherm model, respectively.
32003648	3	60	theme	electrostatic	577:589	arg1	attraction					591:600	electrostatic attraction	577:600	electrostatic attraction between the MCT and the cationic dye	577:637	According to the FTIR spectrum of MCT, the characteristic peaks of the SO3-group on MCT were observed to have a shift after adsorption of the cationic dye, which indicates that there may be electrostatic attraction between the MCT and the cationic dye.
32003648	1	61	theme	@	145:145	arg1	taurine					155:161	A novel magnetic Fe3O4@chitosan@taurine adsorbent	123:171	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT)	123:177	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	1	61	theme	@	145:145	arg1	MCT					174:176	MCT	174:176	MCT	174:176	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	1	62	theme	magnetic	219:226	arg1	nano-composites					237:251	magnetic chitosan nano-composites	219:251	magnetic chitosan nano-composites with taurine-glutaraldehyde solution	219:288	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	0	63	theme	biodegradable	75:87	arg1	adsorbents					89:98	biodegradable adsorbents	75:98	biodegradable adsorbents toward methylene blue	75:120	Facile preparation of taurine modified magnetic chitosan nanocomposites as biodegradable adsorbents toward methylene blue.
32003648	4	64	theme	magnetic	753:760	arg1	response					762:769	magnetic response	753:769	magnetic response	753:769	Moreover, the saturation magnetization of MCT was found to be 20.797 emu g-1, suggesting that MCT has sufficient magnetic response to meet the need of magnetic separation.
32003648	1	65	with	nano-composites	237:251	arg1	solution					281:288	taurine-glutaraldehyde solution	258:288	taurine-glutaraldehyde solution	258:288	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	1	66	theme	chitosan	146:153	arg1	taurine					155:161	A novel magnetic Fe3O4@chitosan@taurine adsorbent	123:171	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT)	123:177	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	1	66	theme	chitosan	146:153	arg1	MCT					174:176	MCT	174:176	MCT	174:176	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	1	67	theme	chitosan	228:235	arg1	nano-composites					237:251	magnetic chitosan nano-composites	219:251	magnetic chitosan nano-composites with taurine-glutaraldehyde solution	219:288	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	6	68	theme	adsorption	942:951	arg1	behaviour					953:961	The adsorption behaviour	938:961	The adsorption behaviour of MB by MCT	938:974	The adsorption behaviour of MB by MCT was well described by the pseudo-second order kinetic model and the Langmuir isotherm model, respectively.
32003648	1	69	theme	@	154:154	arg1	taurine					155:161	A novel magnetic Fe3O4@chitosan@taurine adsorbent	123:171	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT)	123:177	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	1	69	theme	@	154:154	arg1	MCT					174:176	MCT	174:176	MCT	174:176	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32003648	8	70	theme	good	1414:1417	arg1	reusability					1419:1429	the good reusability	1410:1429	the good reusability	1410:1429	Besides, the negative values of ΔG° and ΔH° suggested that the adsorption process was spontaneous and exothermic, and the good reusability indicated that MCT could act as a recyclable adsorbent for dye adsorption.
32003648	1	71	theme	nano-composites	237:251	arg1	modification					203:214	surface modification	195:214	surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution	195:288	A novel magnetic Fe3O4@chitosan@taurine adsorbent (MCT) was prepared by surface modification of magnetic chitosan nano-composites with taurine-glutaraldehyde solution.
32703436	7	0	theme	particle	1211:1218	arg1	distributions					1225:1237	similar particle size distributions	1203:1237	similar particle size distributions	1203:1237	ALFlyo and ALFQ exhibited similar particle size distributions with liposomes ranging from 50 nm to several μm.
32703436	4	1	theme	buffer	804:809	arg1	solution					811:818	aqueous buffer solution	796:818	aqueous buffer solution	796:818	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	9	2	theme	greater	1399:1405	arg1	number					1407:1412	a greater number	1397:1412	a greater number of multilamellar and multivesicular liposome particles	1397:1467	ALFlyo displayed a greater number of multilamellar and multivesicular liposome particles, as compared to that in ALFQ, which was predominately unilamellar.
32703436	2	3	theme	essential	308:316	arg1	ALFQ					289:292	ALFQ	289:292	ALFQ	289:292	ALFlyo and ALFQ adjuvants are essential constituents of candidate vaccines for bacterial, viral, and parasitic diseases.
32703436	2	3	theme	essential	308:316	arg1	ALFlyo					278:283	ALFlyo	278:283	ALFlyo	278:283	ALFlyo and ALFQ adjuvants are essential constituents of candidate vaccines for bacterial, viral, and parasitic diseases.
32703436	2	3	theme	essential	308:316	arg1	constituents					318:329	essential constituents	308:329	essential constituents of candidate vaccines for bacterial, viral, and parasitic diseases	308:396	ALFlyo and ALFQ adjuvants are essential constituents of candidate vaccines for bacterial, viral, and parasitic diseases.
32703436	9	4	theme	multilamellar	1417:1429	arg1	particles					1459:1467	multilamellar and multivesicular liposome particles	1417:1467	multilamellar and multivesicular liposome particles	1417:1467	ALFlyo displayed a greater number of multilamellar and multivesicular liposome particles, as compared to that in ALFQ, which was predominately unilamellar.
32703436	7	5	theme	size	1220:1223	arg1	distributions					1225:1237	similar particle size distributions	1203:1237	similar particle size distributions	1203:1237	ALFlyo and ALFQ exhibited similar particle size distributions with liposomes ranging from 50 nm to several μm.
32703436	4	6	theme	aqueous	796:802	arg1	solution					811:818	aqueous buffer solution	796:818	aqueous buffer solution	796:818	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	1	7	theme	primary	156:162	arg1	forms					164:168	two primary forms	152:168	two primary forms	152:168	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	7	theme	primary	156:162	arg1	ALF					183:185	lyophilized ALF	171:185	lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ)	171:275	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	6	8	theme	size	1003:1006	arg1	distribution					1008:1019	particle size distribution	994:1019	particle size distribution	994:1019	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	4	9	theme	43 mol	772:777	arg1	cholesterol					780:790	43 mol% cholesterol	772:790	43 mol% cholesterol	772:790	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	1	10	theme	Army	78:81	arg1	Formulations					92:103	Army Liposome Formulations	78:103	Army Liposome Formulations (ALF)	78:109	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	10	theme	Army	78:81	arg1	adjuvants					122:130	potent adjuvants	115:130	potent adjuvants	115:130	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	10	theme	Army	78:81	arg1	ALF					106:108	ALF	106:108	ALF	106:108	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	9	11	theme	multivesicular	1435:1448	arg1	particles					1459:1467	multilamellar and multivesicular liposome particles	1417:1467	multilamellar and multivesicular liposome particles	1417:1467	ALFlyo displayed a greater number of multilamellar and multivesicular liposome particles, as compared to that in ALFQ, which was predominately unilamellar.
32703436	6	12	theme	developed	1149:1157	arg1	technology					1165:1174	a newly developed MANTA technology	1141:1174	a newly developed MANTA technology	1141:1174	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	6	13	dep	distribution	1008:1019	arg1	the					990:992	the	990:992	the	990:992	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	1	14	theme	Liposome	83:90	arg1	Formulations					92:103	Army Liposome Formulations	78:103	Army Liposome Formulations (ALF)	78:109	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	14	theme	Liposome	83:90	arg1	adjuvants					122:130	potent adjuvants	115:130	potent adjuvants	115:130	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	14	theme	Liposome	83:90	arg1	ALF					106:108	ALF	106:108	ALF	106:108	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	4	15	theme	55 mol	665:670	arg1	cholesterol					673:683	55 mol% cholesterol	665:683	55 mol% cholesterol	665:683	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	5	16	theme	particle	861:868	arg1	distribution					875:886	heterogenous particle size distribution	848:886	heterogenous particle size distribution	848:886	These formulations display heterogenous particle size distribution.
32703436	6	17	theme	ALFlyo	1077:1082	arg1	formulations					1093:1104	ALFlyo and ALFQ formulations	1077:1104	ALFlyo and ALFQ formulations	1077:1104	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	3	18	theme	non-human	485:493	arg1	primates					495:502	non-human primates	485:502	non-human primates	485:502	They have been widely used in preclinical immunogenicity studies in small animals and non-human primates and are progressing to phase I/IIa clinical trials.
32703436	1	19	theme	lyophilized	171:181	arg1	ALFlyo					188:193	ALFlyo	188:193	ALFlyo	188:193	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	19	theme	lyophilized	171:181	arg1	forms					164:168	two primary forms	152:168	two primary forms	152:168	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	19	theme	lyophilized	171:181	arg1	ALF					183:185	lyophilized ALF	171:185	lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ)	171:275	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	4	20	theme	liposome	618:625	arg1	SUVs					637:640	SUVs	637:640	SUVs	637:640	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	4	20	theme	liposome	618:625	arg1	vesicles					627:634	small unilamellar liposome vesicles	600:634	small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol	600:683	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	6	21	theme	adjuvant	953:960	arg1	potential					962:970	their adjuvant potential	947:970	their adjuvant potential	947:970	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	5	22	theme	heterogenous	848:859	arg1	distribution					875:886	heterogenous particle size distribution	848:886	heterogenous particle size distribution	848:886	These formulations display heterogenous particle size distribution.
32703436	4	23	theme	%	778:778	arg1	cholesterol					780:790	43 mol% cholesterol	772:790	43 mol% cholesterol	772:790	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	4	24	theme	ALF55	646:650	arg1	SUVs					637:640	SUVs	637:640	SUVs	637:640	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	4	24	theme	ALF55	646:650	arg1	vesicles					627:634	small unilamellar liposome vesicles	600:634	small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol	600:683	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	1	25	contain	containing	245:254	arg2	ALFQ					271:274	ALFQ	271:274	ALFQ	271:274	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	25	contain	containing	245:254	arg2	QS21					265:268	QS21	265:268	QS21	265:268	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	25	contain	containing	245:254	arg2	MPLA					256:259	MPLA	256:259	MPLA	256:259	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	25	contain	containing	245:254	arg1	ALF					241:243	ALF	241:243	ALF containing MPLA and QS21 (ALFQ)	241:275	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	4	26	theme	unilamellar	606:616	arg1	SUVs					637:640	SUVs	637:640	SUVs	637:640	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	4	26	theme	unilamellar	606:616	arg1	vesicles					627:634	small unilamellar liposome vesicles	600:634	small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol	600:683	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	4	27	contain	contain	657:663	arg2	cholesterol					673:683	55 mol% cholesterol	665:683	55 mol% cholesterol	665:683	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	4	27	contain	contain	657:663	arg1	SUVs					637:640	SUVs	637:640	SUVs	637:640	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	4	27	contain	contain	657:663	arg1	vesicles					627:634	small unilamellar liposome vesicles	600:634	small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol	600:683	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	6	28	theme	particles	1064:1072	arg1	lamellarity					1025:1035	lamellarity	1025:1035	lamellarity	1025:1035	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	6	28	theme	particles	1064:1072	arg1	distribution					1008:1019	particle size distribution	994:1019	particle size distribution	994:1019	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	6	29	from	distribution	1008:1019	arg1	formulations					1093:1104	ALFlyo and ALFQ formulations	1077:1104	ALFlyo and ALFQ formulations	1077:1104	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	3	30	theme	phase	527:531	arg1	trials					548:553	phase I/IIa clinical trials	527:553	phase I/IIa clinical trials	527:553	They have been widely used in preclinical immunogenicity studies in small animals and non-human primates and are progressing to phase I/IIa clinical trials.
32703436	7	31	theme	several	1276:1282	arg1	μm					1284:1285	several μm	1276:1285	several μm	1276:1285	ALFlyo and ALFQ exhibited similar particle size distributions with liposomes ranging from 50 nm to several μm.
32703436	2	32	theme	vaccines	344:351	arg1	ALFQ					289:292	ALFQ	289:292	ALFQ	289:292	ALFlyo and ALFQ adjuvants are essential constituents of candidate vaccines for bacterial, viral, and parasitic diseases.
32703436	2	32	theme	vaccines	344:351	arg1	ALFlyo					278:283	ALFlyo	278:283	ALFlyo	278:283	ALFlyo and ALFQ adjuvants are essential constituents of candidate vaccines for bacterial, viral, and parasitic diseases.
32703436	2	32	theme	vaccines	344:351	arg1	constituents					318:329	essential constituents	308:329	essential constituents of candidate vaccines for bacterial, viral, and parasitic diseases	308:396	ALFlyo and ALFQ adjuvants are essential constituents of candidate vaccines for bacterial, viral, and parasitic diseases.
32703436	0	33	theme	Biophysical	0:10	arg1	characterization					12:27	Biophysical characterization	0:27	Biophysical characterization of polydisperse liposomal adjuvant formulations.	0:76	Biophysical characterization of polydisperse liposomal adjuvant formulations.
32703436	2	34	dep	ALFlyo	278:283	arg1	adjuvants					294:302	adjuvants	294:302	adjuvants	294:302	ALFlyo and ALFQ adjuvants are essential constituents of candidate vaccines for bacterial, viral, and parasitic diseases.
32703436	2	35	theme	candidate	334:342	arg1	vaccines					344:351	candidate vaccines	334:351	candidate vaccines for bacterial, viral, and parasitic diseases	334:396	ALFlyo and ALFQ adjuvants are essential constituents of candidate vaccines for bacterial, viral, and parasitic diseases.
32703436	0	36	theme	polydisperse	32:43	arg1	formulations					64:75	polydisperse liposomal adjuvant formulations	32:75	polydisperse liposomal adjuvant formulations	32:75	Biophysical characterization of polydisperse liposomal adjuvant formulations.
32703436	8	37	theme	fundamental	1297:1307	arg1	differences					1309:1319	fundamental differences	1297:1319	fundamental differences	1297:1319	However, fundamental differences were observed in the lamellar structures of the liposomes.
32703436	3	38	from	studies	456:462	arg1	animals					473:479	small animals	467:479	small animals	467:479	They have been widely used in preclinical immunogenicity studies in small animals and non-human primates and are progressing to phase I/IIa clinical trials.
32703436	3	38	from	studies	456:462	arg1	primates					495:502	non-human primates	485:502	non-human primates	485:502	They have been widely used in preclinical immunogenicity studies in small animals and non-human primates and are progressing to phase I/IIa clinical trials.
32703436	3	39	used	used	421:424	arg2	They					399:402	They	399:402	They	399:402	They have been widely used in preclinical immunogenicity studies in small animals and non-human primates and are progressing to phase I/IIa clinical trials.
32703436	2	40	theme	parasitic	379:387	arg1	diseases					389:396	parasitic diseases	379:396	parasitic diseases	379:396	ALFlyo and ALFQ adjuvants are essential constituents of candidate vaccines for bacterial, viral, and parasitic diseases.
32703436	1	41	theme	potent	115:120	arg1	Formulations					92:103	Army Liposome Formulations	78:103	Army Liposome Formulations (ALF)	78:109	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	41	theme	potent	115:120	arg1	adjuvants					122:130	potent adjuvants	115:130	potent adjuvants	115:130	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	9	42	theme	liposome	1450:1457	arg1	particles					1459:1467	multilamellar and multivesicular liposome particles	1417:1467	multilamellar and multivesicular liposome particles	1417:1467	ALFlyo displayed a greater number of multilamellar and multivesicular liposome particles, as compared to that in ALFQ, which was predominately unilamellar.
32703436	4	43	theme	saponin	584:590	arg1	QS21					592:595	saponin QS21	584:595	saponin QS21	584:595	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	0	44	theme	adjuvant	55:62	arg1	formulations					64:75	polydisperse liposomal adjuvant formulations	32:75	polydisperse liposomal adjuvant formulations	32:75	Biophysical characterization of polydisperse liposomal adjuvant formulations.
32703436	6	45	theme	cryo-electron	1112:1124	arg1	microscopy					1126:1135	cryo-electron microscopy	1112:1135	cryo-electron microscopy	1112:1135	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	6	46	theme	liposomes	926:934	arg1	characteristics					907:921	biophysical characteristics	895:921	biophysical characteristics of liposomes	895:934	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	4	47	theme	small	600:604	arg1	SUVs					637:640	SUVs	637:640	SUVs	637:640	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	4	47	theme	small	600:604	arg1	vesicles					627:634	small unilamellar liposome vesicles	600:634	small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol	600:683	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	0	48	theme	liposomal	45:53	arg1	formulations					64:75	polydisperse liposomal adjuvant formulations	32:75	polydisperse liposomal adjuvant formulations	32:75	Biophysical characterization of polydisperse liposomal adjuvant formulations.
32703436	6	49	theme	individual	1044:1053	arg1	particles					1064:1072	the individual liposome particles	1040:1072	the individual liposome particles	1040:1072	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	3	50	theme	clinical	539:546	arg1	trials					548:553	phase I/IIa clinical trials	527:553	phase I/IIa clinical trials	527:553	They have been widely used in preclinical immunogenicity studies in small animals and non-human primates and are progressing to phase I/IIa clinical trials.
32703436	8	51	theme	liposomes	1369:1377	arg1	structures					1351:1360	the lamellar structures	1338:1360	the lamellar structures of the liposomes	1338:1377	However, fundamental differences were observed in the lamellar structures of the liposomes.
32703436	3	52	theme	immunogenicity	441:454	arg1	studies					456:462	preclinical immunogenicity studies	429:462	preclinical immunogenicity studies in small animals and non-human primates	429:502	They have been widely used in preclinical immunogenicity studies in small animals and non-human primates and are progressing to phase I/IIa clinical trials.
32703436	0	53	theme	formulations	64:75	arg1	characterization					12:27	Biophysical characterization	0:27	Biophysical characterization of polydisperse liposomal adjuvant formulations.	0:76	Biophysical characterization of polydisperse liposomal adjuvant formulations.
32703436	6	54	theme	biophysical	895:905	arg1	characteristics					907:921	biophysical characteristics	895:921	biophysical characteristics of liposomes	895:934	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	8	55	located	observed	1326:1333	arg2	differences					1309:1319	fundamental differences	1297:1319	fundamental differences	1297:1319	However, fundamental differences were observed in the lamellar structures of the liposomes.
32703436	8	55	located	observed	1326:1333	arg1	structures					1351:1360	the lamellar structures	1338:1360	the lamellar structures of the liposomes	1338:1377	However, fundamental differences were observed in the lamellar structures of the liposomes.
32703436	1	56	contain	containing	196:205	arg1	ALF					183:185	lyophilized ALF	171:185	lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ)	171:275	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	56	contain	containing	196:205	arg2	MPLA					231:234	MPLA	231:234	MPLA	231:234	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	56	contain	containing	196:205	arg2	ALF					241:243	ALF	241:243	ALF containing MPLA and QS21 (ALFQ)	241:275	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	56	contain	containing	196:205	arg1	ALFlyo					188:193	ALFlyo	188:193	ALFlyo	188:193	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	56	contain	containing	196:205	arg1	forms					164:168	two primary forms	152:168	two primary forms	152:168	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	56	contain	containing	196:205	arg2	A					228:228	monophosphoryl lipid A	207:228	monophosphoryl lipid A (MPLA)	207:235	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	9	57	theme	particles	1459:1467	arg1	number					1407:1412	a greater number	1397:1412	a greater number of multilamellar and multivesicular liposome particles	1397:1467	ALFlyo displayed a greater number of multilamellar and multivesicular liposome particles, as compared to that in ALFQ, which was predominately unilamellar.
32703436	3	58	theme	small	467:471	arg1	animals					473:479	small animals	467:479	small animals	467:479	They have been widely used in preclinical immunogenicity studies in small animals and non-human primates and are progressing to phase I/IIa clinical trials.
32703436	5	59	theme	size	870:873	arg1	distribution					875:886	heterogenous particle size distribution	848:886	heterogenous particle size distribution	848:886	These formulations display heterogenous particle size distribution.
32703436	6	60	from	lamellarity	1025:1035	arg1	formulations					1093:1104	ALFlyo and ALFQ formulations	1077:1104	ALFlyo and ALFQ formulations	1077:1104	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	6	61	theme	particle	994:1001	arg1	distribution					1008:1019	particle size distribution	994:1019	particle size distribution	994:1019	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	4	62	theme	%	671:671	arg1	cholesterol					673:683	55 mol% cholesterol	665:683	55 mol% cholesterol	665:683	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	1	63	theme	monophosphoryl	207:220	arg1	A					228:228	monophosphoryl lipid A	207:228	monophosphoryl lipid A (MPLA)	207:235	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	63	theme	monophosphoryl	207:220	arg1	MPLA					231:234	MPLA	231:234	MPLA	231:234	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	6	64	theme	MANTA	1159:1163	arg1	technology					1165:1174	a newly developed MANTA technology	1141:1174	a newly developed MANTA technology	1141:1174	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	4	65	dep	prepared	565:572	arg1	whereas					686:692	whereas	686:692	whereas	686:692	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	4	66	theme	lyophilized	731:741	arg1	SUVs					743:746	lyophilized SUVs	731:746	lyophilized SUVs	731:746	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	3	67	theme	preclinical	429:439	arg1	studies					456:462	preclinical immunogenicity studies	429:462	preclinical immunogenicity studies in small animals and non-human primates	429:502	They have been widely used in preclinical immunogenicity studies in small animals and non-human primates and are progressing to phase I/IIa clinical trials.
32703436	8	68	theme	lamellar	1342:1349	arg1	structures					1351:1360	the lamellar structures	1338:1360	the lamellar structures of the liposomes	1338:1377	However, fundamental differences were observed in the lamellar structures of the liposomes.
32703436	1	69	theme	lipid	222:226	arg1	A					228:228	monophosphoryl lipid A	207:228	monophosphoryl lipid A (MPLA)	207:235	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	1	69	theme	lipid	222:226	arg1	MPLA					231:234	MPLA	231:234	MPLA	231:234	Army Liposome Formulations (ALF) are potent adjuvants, of which there are two primary forms, lyophilized ALF (ALFlyo) containing monophosphoryl lipid A (MPLA) and ALF containing MPLA and QS21 (ALFQ).
32703436	4	70	theme	ALF43	751:755	arg1	SUVs					743:746	lyophilized SUVs	731:746	lyophilized SUVs	731:746	ALFQ was prepared by adding saponin QS21 to small unilamellar liposome vesicles (SUVs) of ALF55 that contain 55 mol% cholesterol, whereas ALFlyo was created by reconstituting lyophilized SUVs of ALF43, consisting of 43 mol% cholesterol, in aqueous buffer solution.
32703436	6	71	theme	ALFQ	1088:1091	arg1	formulations					1093:1104	ALFlyo and ALFQ formulations	1077:1104	ALFlyo and ALFQ formulations	1077:1104	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	6	72	theme	liposome	1055:1062	arg1	particles					1064:1072	the individual liposome particles	1040:1072	the individual liposome particles	1040:1072	Since biophysical characteristics of liposomes may impact their adjuvant potential, we characterized the particle size distribution and lamellarity of the individual liposome particles in ALFlyo and ALFQ formulations using cryo-electron microscopy and a newly developed MANTA technology.
32703436	3	73	theme	I/IIa	533:537	arg1	trials					548:553	phase I/IIa clinical trials	527:553	phase I/IIa clinical trials	527:553	They have been widely used in preclinical immunogenicity studies in small animals and non-human primates and are progressing to phase I/IIa clinical trials.
32703436	7	74	theme	similar	1203:1209	arg1	distributions					1225:1237	similar particle size distributions	1203:1237	similar particle size distributions	1203:1237	ALFlyo and ALFQ exhibited similar particle size distributions with liposomes ranging from 50 nm to several μm.
34361552	5	0	with	comparison	1039:1048	arg1	group					1069:1073	the untreated group	1055:1073	the untreated group	1055:1073	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	4	1	theme	nano-TiO2	716:724	arg1	addition					699:706	the addition	695:706	the addition of 0.5% nano-TiO2 into the CTS	695:737	However, following the addition of 0.5% nano-TiO2 into the CTS, both the mortality and mycelial inhibition rates for MA and ME reached 100%, and the mortality and mycelial inhibition rate for MF also increased significantly, reaching 75.4% and 57.3%, respectively.
34361552	6	2	theme	coatings	1329:1336	arg1	potential					1292:1300	the potential	1288:1300	the potential of CTS/nano-TiO2 composite coatings	1288:1336	Thus, this research revealed the potential of CTS/nano-TiO2 composite coatings in the development of new antimicrobial materials.
34361552	4	3	theme	mortality	749:757	arg1	rates					783:787	both the mortality and mycelial inhibition rates	740:787	rates	783:787	However, following the addition of 0.5% nano-TiO2 into the CTS, both the mortality and mycelial inhibition rates for MA and ME reached 100%, and the mortality and mycelial inhibition rate for MF also increased significantly, reaching 75.4% and 57.3%, respectively.
34361552	4	4	theme	%	714:714	arg1	nano-TiO2					716:724	0.5% nano-TiO2	711:724	0.5% nano-TiO2 into the CTS	711:737	However, following the addition of 0.5% nano-TiO2 into the CTS, both the mortality and mycelial inhibition rates for MA and ME reached 100%, and the mortality and mycelial inhibition rate for MF also increased significantly, reaching 75.4% and 57.3%, respectively.
34361552	5	5	theme	extravasation	1191:1203	arg1	degree					1205:1210	extravasation degree	1191:1210	extravasation degree	1191:1210	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	1	6	theme	causal	247:252	arg1	C.oxysporum					202:212	C.oxysporum	202:212	C.oxysporum (ME)	202:217	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	1	6	theme	causal	247:252	arg1	gloeosporioides					180:194	C. gloeosporioides	177:194	C. gloeosporioides (MA)	177:199	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	1	6	theme	causal	247:252	arg1	steckii					226:232	P. steckii	223:232	P. steckii (MF)	223:237	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	1	6	theme	causal	247:252	arg1	pathogens					159:167	Postharvest pathogens	147:167	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF)	147:237	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	1	6	theme	causal	247:252	arg1	agents					254:259	the causal agents	243:259	the causal agents of disease in mangoes	243:281	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	3	7	theme	ME	492:493	arg1	rates					479:483	the rates	475:483	the rates of MA, ME and MF mortality following the single chitosan treatment	475:550	The results indicated that, the rates of MA, ME and MF mortality following the single chitosan treatment were 63.3%, 84.8% and 43.5%, respectively, while the rates of mycelial inhibition were 84.0%, 100% and 25.8%, respectively.
34361552	3	7	theme	ME	492:493	arg1	%					561:561	63.3%	557:561	63.3%	557:561	The results indicated that, the rates of MA, ME and MF mortality following the single chitosan treatment were 63.3%, 84.8% and 43.5%, respectively, while the rates of mycelial inhibition were 84.0%, 100% and 25.8%, respectively.
34361552	4	8	theme	mycelial	839:846	arg1	rate					859:862	the mortality and mycelial inhibition rate	821:862	rate	859:862	However, following the addition of 0.5% nano-TiO2 into the CTS, both the mortality and mycelial inhibition rates for MA and ME reached 100%, and the mortality and mycelial inhibition rate for MF also increased significantly, reaching 75.4% and 57.3%, respectively.
34361552	6	9	theme	composite	1319:1327	arg1	coatings					1329:1336	CTS/nano-TiO2 composite coatings	1305:1336	CTS/nano-TiO2 composite coatings	1305:1336	Thus, this research revealed the potential of CTS/nano-TiO2 composite coatings in the development of new antimicrobial materials.
34361552	5	10	theme	%	995:995	arg1	treatment					1007:1015	the CTS/0.5% nano-TiO2 treatment	984:1015	the CTS/0.5% nano-TiO2 treatment	984:1015	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	3	11	theme	mycelial	614:621	arg1	inhibition					623:632	mycelial inhibition	614:632	mycelial inhibition	614:632	The results indicated that, the rates of MA, ME and MF mortality following the single chitosan treatment were 63.3%, 84.8% and 43.5%, respectively, while the rates of mycelial inhibition were 84.0%, 100% and 25.8%, respectively.
34361552	5	12	theme	nucleic	1215:1221	arg1	acids					1223:1227	nucleic acids	1215:1227	nucleic acids	1215:1227	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	6	13	theme	CTS/nano-TiO2	1305:1317	arg1	coatings					1329:1336	CTS/nano-TiO2 composite coatings	1305:1336	CTS/nano-TiO2 composite coatings	1305:1336	Thus, this research revealed the potential of CTS/nano-TiO2 composite coatings in the development of new antimicrobial materials.
34361552	5	14	theme	acids	1223:1227	arg1	rate					1182:1185	the protein dissolution rate	1158:1185	the protein dissolution rate	1158:1185	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	5	14	theme	acids	1223:1227	arg1	degree					1205:1210	extravasation degree	1191:1210	extravasation degree	1191:1210	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	2	15	theme	composite	406:414	arg1	coating					416:422	a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating	360:422	a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF	360:444	This paper presents an in vitro investigation into the antifungal effect of a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF.
34361552	4	16	theme	0.5	711:713	arg1	%					714:714	%	714:714	%	714:714	However, following the addition of 0.5% nano-TiO2 into the CTS, both the mortality and mycelial inhibition rates for MA and ME reached 100%, and the mortality and mycelial inhibition rate for MF also increased significantly, reaching 75.4% and 57.3%, respectively.
34361552	5	17	theme	protein	1162:1168	arg1	rate					1182:1185	the protein dissolution rate	1158:1185	the protein dissolution rate	1158:1185	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	2	18	dep	in	307:308	arg1	vitro					310:314	vitro	310:314	vitro	310:314	This paper presents an in vitro investigation into the antifungal effect of a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF.
34361552	0	19	theme	Antifungal	0:9	arg1	Effect					11:16	Antifungal Effect	0:16	Antifungal Effect of Chitosan/Nano-TiO2 Composite Coatings against Colletotrichum gloeosporioides, Cladosporium oxysporum and Penicillium steckii.	0:145	Antifungal Effect of Chitosan/Nano-TiO2 Composite Coatings against Colletotrichum gloeosporioides, Cladosporium oxysporum and Penicillium steckii.
34361552	5	20	theme	dry	956:958	arg1	weight					960:965	the dry weight	952:965	the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment	952:1015	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	5	21	theme	dissolution	1170:1180	arg1	rate					1182:1185	the protein dissolution rate	1158:1185	the protein dissolution rate	1158:1185	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	0	22	theme	Chitosan/Nano-TiO2	21:38	arg1	Coatings					50:57	Chitosan/Nano-TiO2 Composite Coatings	21:57	Chitosan/Nano-TiO2 Composite Coatings	21:57	Antifungal Effect of Chitosan/Nano-TiO2 Composite Coatings against Colletotrichum gloeosporioides, Cladosporium oxysporum and Penicillium steckii.
34361552	1	23	theme	disease	264:270	arg1	C.oxysporum					202:212	C.oxysporum	202:212	C.oxysporum (ME)	202:217	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	1	23	theme	disease	264:270	arg1	gloeosporioides					180:194	C. gloeosporioides	177:194	C. gloeosporioides (MA)	177:199	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	1	23	theme	disease	264:270	arg1	steckii					226:232	P. steckii	223:232	P. steckii (MF)	223:237	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	1	23	theme	disease	264:270	arg1	pathogens					159:167	Postharvest pathogens	147:167	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF)	147:237	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	1	23	theme	disease	264:270	arg1	agents					254:259	the causal agents	243:259	the causal agents of disease in mangoes	243:281	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	3	24	theme	MA	488:489	arg1	rates					479:483	the rates	475:483	the rates of MA, ME and MF mortality following the single chitosan treatment	475:550	The results indicated that, the rates of MA, ME and MF mortality following the single chitosan treatment were 63.3%, 84.8% and 43.5%, respectively, while the rates of mycelial inhibition were 84.0%, 100% and 25.8%, respectively.
34361552	3	24	theme	MA	488:489	arg1	%					561:561	63.3%	557:561	63.3%	557:561	The results indicated that, the rates of MA, ME and MF mortality following the single chitosan treatment were 63.3%, 84.8% and 43.5%, respectively, while the rates of mycelial inhibition were 84.0%, 100% and 25.8%, respectively.
34361552	2	25	theme	dioxide	391:397	arg1	coating					416:422	a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating	360:422	a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF	360:444	This paper presents an in vitro investigation into the antifungal effect of a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF.
34361552	4	26	theme	inhibition	848:857	arg1	rate					859:862	the mortality and mycelial inhibition rate	821:862	rate	859:862	However, following the addition of 0.5% nano-TiO2 into the CTS, both the mortality and mycelial inhibition rates for MA and ME reached 100%, and the mortality and mycelial inhibition rate for MF also increased significantly, reaching 75.4% and 57.3%, respectively.
34361552	3	27	theme	inhibition	623:632	arg1	rates					605:609	the rates	601:609	the rates of mycelial inhibition	601:632	The results indicated that, the rates of MA, ME and MF mortality following the single chitosan treatment were 63.3%, 84.8% and 43.5%, respectively, while the rates of mycelial inhibition were 84.0%, 100% and 25.8%, respectively.
34361552	3	27	theme	inhibition	623:632	arg1	%					643:643	84.0%	639:643	84.0%	639:643	The results indicated that, the rates of MA, ME and MF mortality following the single chitosan treatment were 63.3%, 84.8% and 43.5%, respectively, while the rates of mycelial inhibition were 84.0%, 100% and 25.8%, respectively.
34361552	1	28	from	agents	254:259	arg1	mangoes					275:281	mangoes	275:281	mangoes	275:281	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	2	29	theme	/nano-titanium	376:389	arg1	coating					416:422	a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating	360:422	a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF	360:444	This paper presents an in vitro investigation into the antifungal effect of a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF.
34361552	0	30	theme	Coatings	50:57	arg1	Effect					11:16	Antifungal Effect	0:16	Antifungal Effect of Chitosan/Nano-TiO2 Composite Coatings against Colletotrichum gloeosporioides, Cladosporium oxysporum and Penicillium steckii.	0:145	Antifungal Effect of Chitosan/Nano-TiO2 Composite Coatings against Colletotrichum gloeosporioides, Cladosporium oxysporum and Penicillium steckii.
34361552	5	31	theme	mycelia	970:976	arg1	weight					960:965	the dry weight	952:965	the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment	952:1015	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	4	32	theme	inhibition	772:781	arg1	rates					783:787	both the mortality and mycelial inhibition rates	740:787	rates	783:787	However, following the addition of 0.5% nano-TiO2 into the CTS, both the mortality and mycelial inhibition rates for MA and ME reached 100%, and the mortality and mycelial inhibition rate for MF also increased significantly, reaching 75.4% and 57.3%, respectively.
34361552	5	33	theme	conductivity	1086:1097	arg1	times					1119:1123	about 1.7 times	1109:1123	about 1.7 times that of the untreated group	1109:1151	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	5	33	theme	conductivity	1086:1097	arg1	value					1099:1103	the conductivity value	1082:1103	the conductivity value	1082:1103	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	0	34	theme	Composite	40:48	arg1	Coatings					50:57	Chitosan/Nano-TiO2 Composite Coatings	21:57	Chitosan/Nano-TiO2 Composite Coatings	21:57	Antifungal Effect of Chitosan/Nano-TiO2 Composite Coatings against Colletotrichum gloeosporioides, Cladosporium oxysporum and Penicillium steckii.
34361552	6	35	theme	antimicrobial	1364:1376	arg1	materials					1378:1386	new antimicrobial materials	1360:1386	new antimicrobial materials	1360:1386	Thus, this research revealed the potential of CTS/nano-TiO2 composite coatings in the development of new antimicrobial materials.
34361552	4	36	theme	mycelial	763:770	arg1	inhibition					772:781	mycelial inhibition	763:781	mycelial inhibition	763:781	However, following the addition of 0.5% nano-TiO2 into the CTS, both the mortality and mycelial inhibition rates for MA and ME reached 100%, and the mortality and mycelial inhibition rate for MF also increased significantly, reaching 75.4% and 57.3%, respectively.
34361552	2	37	theme	TiO2	400:403	arg1	coating					416:422	a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating	360:422	a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF	360:444	This paper presents an in vitro investigation into the antifungal effect of a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF.
34361552	5	38	theme	untreated	1137:1145	arg1	group					1147:1151	the untreated group	1133:1151	the untreated group	1133:1151	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	3	39	theme	MF	499:500	arg1	mortality					502:510	MF mortality	499:510	MF mortality	499:510	The results indicated that, the rates of MA, ME and MF mortality following the single chitosan treatment were 63.3%, 84.8% and 43.5%, respectively, while the rates of mycelial inhibition were 84.0%, 100% and 25.8%, respectively.
34361552	5	40	theme	group	1147:1151	arg1	times					1119:1123	about 1.7 times	1109:1123	about 1.7 times that of the untreated group	1109:1151	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	5	40	theme	group	1147:1151	arg1	value					1099:1103	the conductivity value	1082:1103	the conductivity value	1082:1103	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	1	41	theme	Postharvest	147:157	arg1	C.oxysporum					202:212	C.oxysporum	202:212	C.oxysporum (ME)	202:217	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	1	41	theme	Postharvest	147:157	arg1	gloeosporioides					180:194	C. gloeosporioides	177:194	C. gloeosporioides (MA)	177:199	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	1	41	theme	Postharvest	147:157	arg1	steckii					226:232	P. steckii	223:232	P. steckii (MF)	223:237	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	1	41	theme	Postharvest	147:157	arg1	pathogens					159:167	Postharvest pathogens	147:167	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF)	147:237	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	1	41	theme	Postharvest	147:157	arg1	agents					254:259	the causal agents	243:259	the causal agents of disease in mangoes	243:281	Postharvest pathogens such as C. gloeosporioides (MA), C.oxysporum (ME) and P. steckii (MF) are the causal agents of disease in mangoes.
34361552	2	42	theme	coating	416:422	arg1	effect					350:355	the antifungal effect	335:355	the antifungal effect of a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF	335:444	This paper presents an in vitro investigation into the antifungal effect of a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF.
34361552	3	43	theme	mortality	502:510	arg1	rates					479:483	the rates	475:483	the rates of MA, ME and MF mortality following the single chitosan treatment	475:550	The results indicated that, the rates of MA, ME and MF mortality following the single chitosan treatment were 63.3%, 84.8% and 43.5%, respectively, while the rates of mycelial inhibition were 84.0%, 100% and 25.8%, respectively.
34361552	3	43	theme	mortality	502:510	arg1	%					561:561	63.3%	557:561	63.3%	557:561	The results indicated that, the rates of MA, ME and MF mortality following the single chitosan treatment were 63.3%, 84.8% and 43.5%, respectively, while the rates of mycelial inhibition were 84.0%, 100% and 25.8%, respectively.
34361552	6	44	theme	new	1360:1362	arg1	materials					1378:1386	new antimicrobial materials	1360:1386	new antimicrobial materials	1360:1386	Thus, this research revealed the potential of CTS/nano-TiO2 composite coatings in the development of new antimicrobial materials.
34361552	2	45	theme	in	307:308	arg1	investigation					316:328	an in vitro investigation	304:328	an in vitro investigation into the antifungal effect of a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF	304:444	This paper presents an in vitro investigation into the antifungal effect of a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF.
34361552	5	46	theme	nano-TiO2	997:1005	arg1	treatment					1007:1015	the CTS/0.5% nano-TiO2 treatment	984:1015	the CTS/0.5% nano-TiO2 treatment	984:1015	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	6	47	theme	materials	1378:1386	arg1	development					1345:1355	the development	1341:1355	the development of new antimicrobial materials	1341:1386	Thus, this research revealed the potential of CTS/nano-TiO2 composite coatings in the development of new antimicrobial materials.
34361552	5	48	theme	untreated	1059:1067	arg1	group					1069:1073	the untreated group	1055:1073	the untreated group	1055:1073	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	3	49	theme	single	526:531	arg1	chitosan					533:540	the single chitosan	522:540	the single chitosan treatment	522:550	The results indicated that, the rates of MA, ME and MF mortality following the single chitosan treatment were 63.3%, 84.8% and 43.5%, respectively, while the rates of mycelial inhibition were 84.0%, 100% and 25.8%, respectively.
34361552	5	50	theme	CTS/0.5	988:994	arg1	%					995:995	%	995:995	%	995:995	In the MA, the dry weight of mycelia after the CTS/0.5% nano-TiO2 treatment decreased by 36.3% in comparison with the untreated group, while the conductivity value was about 1.7 times that of the untreated group, and the protein dissolution rate and extravasation degree of nucleic acids also increased significantly.
34361552	3	51	theme	chitosan	533:540	arg1	treatment					542:550	the single chitosan treatment	522:550	the single chitosan treatment	522:550	The results indicated that, the rates of MA, ME and MF mortality following the single chitosan treatment were 63.3%, 84.8% and 43.5%, respectively, while the rates of mycelial inhibition were 84.0%, 100% and 25.8%, respectively.
34361552	2	52	theme	antifungal	339:348	arg1	effect					350:355	the antifungal effect	335:355	the antifungal effect of a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF	335:444	This paper presents an in vitro investigation into the antifungal effect of a chitosan (CTS)/nano-titanium dioxide (TiO2) composite coating against MA, ME and MF.
33418207	0	0	theme	spinal	83:88	arg1	injury					95:100	spinal cord injury	83:100	spinal cord injury	83:100	A sandwich structured drug delivery composite membrane for improved recovery after spinal cord injury under longtime controlled release.
33418207	2	1	theme	sandwich	445:452	arg1	layer					454:458	the sandwich layer	441:458	the sandwich layer to load and controlled release NGF	441:493	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	1	2	theme	composite	159:167	arg1	membrane					169:176	A sandwich structured composite membrane	137:176	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI)	137:272	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	1	3	theme	repair	242:247	arg1	cord					256:259	repair spinal cord	242:259	repair spinal cord injury (SCI)	242:272	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	3	4	theme	good	620:623	arg1	biocompatibility					625:640	good biocompatibility	620:640	good biocompatibility	620:640	The composite membrane has good biocompatibility and can effectively promote PC-12 cells to differentiate into neurons.
33418207	3	5	theme	composite	597:605	arg1	membrane					607:614	The composite membrane	593:614	The composite membrane	593:614	The composite membrane has good biocompatibility and can effectively promote PC-12 cells to differentiate into neurons.
33418207	2	6	theme	planting	526:533	arg1	film					328:331	PLA film	324:331	PLA film	324:331	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	2	6	theme	planting	526:533	arg1	layer					535:539	the planting layer	522:539	the planting layer to seed bone marrow mesenchymal stem cells (BMSCs)	522:590	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	2	7	theme	drug	373:376	arg1	diffusion					378:386	drug diffusion	373:386	drug diffusion	373:386	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	2	8	theme	PLA	324:326	arg1	layer					535:539	the planting layer	522:539	the planting layer to seed bone marrow mesenchymal stem cells (BMSCs)	522:590	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	2	8	theme	PLA	324:326	arg1	film					328:331	PLA film	324:331	PLA film	324:331	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	2	8	theme	PLA	324:326	arg1	layer					356:360	the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film	344:517	the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film	344:517	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	1	9	theme	spinal	249:254	arg1	cord					256:259	repair spinal cord	242:259	repair spinal cord injury (SCI)	242:272	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	2	10	theme	release	483:489	arg1	NGF					491:493	controlled release NGF	472:493	controlled release NGF	472:493	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	7	11	theme	SCI	1300:1302	arg1	treatment					1287:1295	the treatment	1283:1295	the treatment of SCI by the NGF-loaded sandwich composite membrane with prolonged drug release function	1283:1385	Overall, this present work provides a future perspective for the treatment of SCI by the NGF-loaded sandwich composite membrane with prolonged drug release function.
33418207	4	12	theme	further	802:808	arg1	damage					810:815	further damage	802:815	further damage	802:815	In addition, the composite membrane can be directly applied to the injured areas without further damage.
33418207	1	13	theme	cord	256:259	arg1	SCI					269:271	SCI	269:271	SCI	269:271	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	1	13	theme	cord	256:259	arg1	injury					261:266	repair spinal cord injury	242:266	repair spinal cord injury (SCI)	242:272	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	0	14	theme	cord	90:93	arg1	injury					95:100	spinal cord injury	83:100	spinal cord injury	83:100	A sandwich structured drug delivery composite membrane for improved recovery after spinal cord injury under longtime controlled release.
33418207	6	15	theme	functions	1211:1219	arg1	recovery					1189:1196	the recovery	1185:1196	the recovery of locomotor functions	1185:1219	The administration of BMSCs coupled with the sandwich composite membrane effectively relieves SCI, decreases cavity formation, enhances neuronal regeneration and tissue repair, as well as improves the recovery of locomotor functions.
33418207	2	16	theme	stem	573:576	arg1	cells					578:582	mesenchymal stem cells	561:582	seed bone marrow mesenchymal stem cells (BMSCs)	544:590	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	2	16	theme	stem	573:576	arg1	BMSCs					585:589	BMSCs	585:589	BMSCs	585:589	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	5	17	theme	SCI	895:897	arg1	repair					899:904	SCI repair	895:904	SCI repair	895:904	The longtime sustained release of NGF guaranteed enough requirement time for SCI repair, which will decrease the administration frequency and improve patient compliance.
33418207	0	18	theme	longtime	108:115	arg1	release					128:134	longtime controlled release	108:134	longtime controlled release	108:134	A sandwich structured drug delivery composite membrane for improved recovery after spinal cord injury under longtime controlled release.
33418207	6	19	theme	locomotor	1201:1209	arg1	functions					1211:1219	locomotor functions	1201:1219	locomotor functions	1201:1219	The administration of BMSCs coupled with the sandwich composite membrane effectively relieves SCI, decreases cavity formation, enhances neuronal regeneration and tissue repair, as well as improves the recovery of locomotor functions.
33418207	2	20	used	used	336:339	arg2	layer					535:539	the planting layer	522:539	the planting layer to seed bone marrow mesenchymal stem cells (BMSCs)	522:590	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	2	20	used	used	336:339	arg2	film					328:331	PLA film	324:331	PLA film	324:331	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	2	20	used	used	336:339	arg2	layer					356:360	the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film	344:517	the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film	344:517	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	7	21	theme	drug	1365:1368	arg1	function					1378:1385	prolonged drug release function	1355:1385	prolonged drug release function	1355:1385	Overall, this present work provides a future perspective for the treatment of SCI by the NGF-loaded sandwich composite membrane with prolonged drug release function.
33418207	5	22	theme	longtime	822:829	arg1	release					841:847	The longtime sustained release	818:847	The longtime sustained release of NGF	818:854	The longtime sustained release of NGF guaranteed enough requirement time for SCI repair, which will decrease the administration frequency and improve patient compliance.
33418207	2	23	theme	bone	549:552	arg1	marrow					554:559	seed bone marrow mesenchymal stem cells (BMSCs)	544:590	seed bone marrow mesenchymal stem cells (BMSCs)	544:590	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	7	24	theme	release	1370:1376	arg1	function					1378:1385	prolonged drug release function	1355:1385	prolonged drug release function	1355:1385	Overall, this present work provides a future perspective for the treatment of SCI by the NGF-loaded sandwich composite membrane with prolonged drug release function.
33418207	1	25	theme	longtime	182:189	arg1	release					202:208	longtime controlled release	182:208	longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI)	182:272	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	0	26	theme	sandwich	2:9	arg1	delivery					27:34	A sandwich structured drug delivery	0:34	A sandwich structured drug delivery	0:34	A sandwich structured drug delivery composite membrane for improved recovery after spinal cord injury under longtime controlled release.
33418207	2	27	theme	seed	544:547	arg1	marrow					554:559	seed bone marrow mesenchymal stem cells (BMSCs)	544:590	seed bone marrow mesenchymal stem cells (BMSCs)	544:590	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	1	28	theme	controlled	191:200	arg1	release					202:208	longtime controlled release	182:208	longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI)	182:272	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	2	29	theme	mechanical	400:409	arg1	support					411:417	mechanical support	400:417	mechanical support	400:417	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	6	30	theme	cavity	1097:1102	arg1	formation					1104:1112	cavity formation	1097:1112	cavity formation	1097:1112	The administration of BMSCs coupled with the sandwich composite membrane effectively relieves SCI, decreases cavity formation, enhances neuronal regeneration and tissue repair, as well as improves the recovery of locomotor functions.
33418207	4	31	theme	injured	780:786	arg1	areas					788:792	the injured areas	776:792	the injured areas without further damage	776:815	In addition, the composite membrane can be directly applied to the injured areas without further damage.
33418207	0	32	theme	drug	22:25	arg1	delivery					27:34	A sandwich structured drug delivery	0:34	A sandwich structured drug delivery	0:34	A sandwich structured drug delivery composite membrane for improved recovery after spinal cord injury under longtime controlled release.
33418207	6	33	theme	BMSCs	1010:1014	arg1	administration					992:1005	The administration	988:1005	The administration of BMSCs coupled with the sandwich composite membrane	988:1059	The administration of BMSCs coupled with the sandwich composite membrane effectively relieves SCI, decreases cavity formation, enhances neuronal regeneration and tissue repair, as well as improves the recovery of locomotor functions.
33418207	2	34	theme	chitosan	500:507	arg1	film					514:517	chitosan (CS) film	500:517	chitosan (CS) film	500:517	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	2	35	theme	mesenchymal	561:571	arg1	cells					578:582	mesenchymal stem cells	561:582	seed bone marrow mesenchymal stem cells (BMSCs)	544:590	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	2	35	theme	mesenchymal	561:571	arg1	BMSCs					585:589	BMSCs	585:589	BMSCs	585:589	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	7	36	theme	composite	1331:1339	arg1	membrane					1341:1348	the NGF-loaded sandwich composite membrane	1307:1348	the NGF-loaded sandwich composite membrane	1307:1348	Overall, this present work provides a future perspective for the treatment of SCI by the NGF-loaded sandwich composite membrane with prolonged drug release function.
33418207	7	37	theme	NGF-loaded	1311:1320	arg1	membrane					1341:1348	the NGF-loaded sandwich composite membrane	1307:1348	the NGF-loaded sandwich composite membrane	1307:1348	Overall, this present work provides a future perspective for the treatment of SCI by the NGF-loaded sandwich composite membrane with prolonged drug release function.
33418207	0	38	theme	structured	11:20	arg1	delivery					27:34	A sandwich structured drug delivery	0:34	A sandwich structured drug delivery	0:34	A sandwich structured drug delivery composite membrane for improved recovery after spinal cord injury under longtime controlled release.
33418207	0	39	theme	controlled	117:126	arg1	release					128:134	longtime controlled release	108:134	longtime controlled release	108:134	A sandwich structured drug delivery composite membrane for improved recovery after spinal cord injury under longtime controlled release.
33418207	7	40	with	treatment	1287:1295	arg1	function					1378:1385	prolonged drug release function	1355:1385	prolonged drug release function	1355:1385	Overall, this present work provides a future perspective for the treatment of SCI by the NGF-loaded sandwich composite membrane with prolonged drug release function.
33418207	3	41	contain	has	616:618	arg1	membrane					607:614	The composite membrane	593:614	The composite membrane	593:614	The composite membrane has good biocompatibility and can effectively promote PC-12 cells to differentiate into neurons.
33418207	3	41	contain	has	616:618	arg2	biocompatibility					625:640	good biocompatibility	620:640	good biocompatibility	620:640	The composite membrane has good biocompatibility and can effectively promote PC-12 cells to differentiate into neurons.
33418207	1	42	theme	nerve	213:217	arg1	NGF					234:236	NGF	234:236	NGF	234:236	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	1	42	theme	nerve	213:217	arg1	factor					226:231	nerve growth factor	213:231	nerve growth factor (NGF)	213:237	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	7	43	theme	present	1236:1242	arg1	work					1244:1247	this present work	1231:1247	this present work	1231:1247	Overall, this present work provides a future perspective for the treatment of SCI by the NGF-loaded sandwich composite membrane with prolonged drug release function.
33418207	3	44	theme	PC-12	670:674	arg1	cells					676:680	PC-12 cells	670:680	PC-12 cells	670:680	The composite membrane has good biocompatibility and can effectively promote PC-12 cells to differentiate into neurons.
33418207	5	45	theme	administration	931:944	arg1	frequency					946:954	the administration frequency	927:954	the administration frequency	927:954	The longtime sustained release of NGF guaranteed enough requirement time for SCI repair, which will decrease the administration frequency and improve patient compliance.
33418207	7	46	theme	future	1260:1265	arg1	perspective					1267:1277	a future perspective	1258:1277	a future perspective for the treatment of SCI by the NGF-loaded sandwich composite membrane with prolonged drug release function	1258:1385	Overall, this present work provides a future perspective for the treatment of SCI by the NGF-loaded sandwich composite membrane with prolonged drug release function.
33418207	1	47	theme	growth	219:224	arg1	NGF					234:236	NGF	234:236	NGF	234:236	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	1	47	theme	growth	219:224	arg1	factor					226:231	nerve growth factor	213:231	nerve growth factor (NGF)	213:237	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	2	48	dep	marrow	554:559	arg1	cells					578:582	mesenchymal stem cells	561:582	seed bone marrow mesenchymal stem cells (BMSCs)	544:590	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	2	48	dep	marrow	554:559	arg1	BMSCs					585:589	BMSCs	585:589	BMSCs	585:589	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	1	49	theme	factor	226:231	arg1	release					202:208	longtime controlled release	182:208	longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI)	182:272	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	2	50	theme	PLGA	420:423	arg1	microspheres					425:436	PLGA microspheres	420:436	PLGA microspheres as the sandwich layer to load and controlled release NGF	420:493	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	7	51	theme	sandwich	1322:1329	arg1	membrane					1341:1348	the NGF-loaded sandwich composite membrane	1307:1348	the NGF-loaded sandwich composite membrane	1307:1348	Overall, this present work provides a future perspective for the treatment of SCI by the NGF-loaded sandwich composite membrane with prolonged drug release function.
33418207	6	52	theme	composite	1042:1050	arg1	membrane					1052:1059	the sandwich composite membrane	1029:1059	the sandwich composite membrane	1029:1059	The administration of BMSCs coupled with the sandwich composite membrane effectively relieves SCI, decreases cavity formation, enhances neuronal regeneration and tissue repair, as well as improves the recovery of locomotor functions.
33418207	5	53	theme	sustained	831:839	arg1	release					841:847	The longtime sustained release	818:847	The longtime sustained release of NGF	818:854	The longtime sustained release of NGF guaranteed enough requirement time for SCI repair, which will decrease the administration frequency and improve patient compliance.
33418207	6	54	theme	neuronal	1124:1131	arg1	regeneration					1133:1144	neuronal regeneration	1124:1144	neuronal regeneration	1124:1144	The administration of BMSCs coupled with the sandwich composite membrane effectively relieves SCI, decreases cavity formation, enhances neuronal regeneration and tissue repair, as well as improves the recovery of locomotor functions.
33418207	5	55	theme	patient	968:974	arg1	compliance					976:985	patient compliance	968:985	patient compliance	968:985	The longtime sustained release of NGF guaranteed enough requirement time for SCI repair, which will decrease the administration frequency and improve patient compliance.
33418207	4	56	theme	composite	730:738	arg1	membrane					740:747	the composite membrane	726:747	the composite membrane	726:747	In addition, the composite membrane can be directly applied to the injured areas without further damage.
33418207	7	57	theme	prolonged	1355:1363	arg1	function					1378:1385	prolonged drug release function	1355:1385	prolonged drug release function	1355:1385	Overall, this present work provides a future perspective for the treatment of SCI by the NGF-loaded sandwich composite membrane with prolonged drug release function.
33418207	5	58	dep	requirement	874:884	arg1	time					886:889	time	886:889	requirement time for SCI repair, which will decrease the administration frequency and improve patient compliance	874:985	The longtime sustained release of NGF guaranteed enough requirement time for SCI repair, which will decrease the administration frequency and improve patient compliance.
33418207	5	59	theme	NGF	852:854	arg1	release					841:847	The longtime sustained release	818:847	The longtime sustained release of NGF	818:854	The longtime sustained release of NGF guaranteed enough requirement time for SCI repair, which will decrease the administration frequency and improve patient compliance.
33418207	6	60	theme	sandwich	1033:1040	arg1	membrane					1052:1059	the sandwich composite membrane	1029:1059	the sandwich composite membrane	1029:1059	The administration of BMSCs coupled with the sandwich composite membrane effectively relieves SCI, decreases cavity formation, enhances neuronal regeneration and tissue repair, as well as improves the recovery of locomotor functions.
33418207	6	61	theme	tissue	1150:1155	arg1	repair					1157:1162	tissue repair	1150:1162	tissue repair	1150:1162	The administration of BMSCs coupled with the sandwich composite membrane effectively relieves SCI, decreases cavity formation, enhances neuronal regeneration and tissue repair, as well as improves the recovery of locomotor functions.
33418207	1	62	theme	sandwich	139:146	arg1	membrane					169:176	A sandwich structured composite membrane	137:176	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI)	137:272	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	2	63	theme	sealing	348:354	arg1	film					328:331	PLA film	324:331	PLA film	324:331	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	2	63	theme	sealing	348:354	arg1	layer					356:360	the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film	344:517	the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film	344:517	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
33418207	0	64	theme	improved	59:66	arg1	recovery					68:75	improved recovery	59:75	improved recovery after spinal cord injury	59:100	A sandwich structured drug delivery composite membrane for improved recovery after spinal cord injury under longtime controlled release.
33418207	1	65	theme	structured	148:157	arg1	membrane					169:176	A sandwich structured composite membrane	137:176	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI)	137:272	A sandwich structured composite membrane for longtime controlled release of nerve growth factor (NGF) to repair spinal cord injury (SCI) is prepared through electrospray.
33418207	2	66	theme	controlled	472:481	arg1	NGF					491:493	controlled release NGF	472:493	controlled release NGF	472:493	In this system, PLA film is used as the sealing layer to prevent drug diffusion and provide mechanical support, PLGA microspheres as the sandwich layer to load and controlled release NGF, and chitosan (CS) film as the planting layer to seed bone marrow mesenchymal stem cells (BMSCs).
32305005	0	0	theme	DSS-induced	94:104	arg1	restriction					82:92	intermittent energy restriction DSS-induced	62:104	intermittent energy restriction DSS-induced	62:104	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.
32305005	4	1	theme	gut	774:776	arg1	integrity					786:794	the gut barrier integrity	770:794	the gut barrier integrity	770:794	TRF and IER, but not ADF, reversed the colitis pathological development by improving the gut barrier integrity and colon length.
32305005	7	2	theme	enrichments	1177:1187	arg1	decrease					1161:1168	the decrease	1157:1168	the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli	1157:1253	TRF and IER also altered the gut microbiota composition, including the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli, and increase of the enrichments of anti-inflammatory-related microbes.
32305005	7	2	theme	enrichments	1177:1187	arg1	increase					1260:1267	increase	1260:1267	increase of the enrichments of anti-inflammatory-related microbes	1260:1324	TRF and IER also altered the gut microbiota composition, including the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli, and increase of the enrichments of anti-inflammatory-related microbes.
32305005	1	3	theme	gut	253:255	arg1	inflammation					257:268	gut inflammation	253:268	gut inflammation	253:268	Intermittent fasting (IF) has been reported to have beneficial effects on improving gut function via lowering gut inflammation and altering the gut microbiome diversity.
32305005	0	4	theme	restriction	82:92	arg1	Effects					0:6	Effects	0:6	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.	0:141	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.
32305005	9	5	theme	microbiome	1586:1595	arg1	compositions					1597:1608	the gut microbiome compositions	1578:1608	the gut microbiome compositions	1578:1608	In conclusion, the TRF and IER but not ADF exhibited the protective effects against colitis and related behavioral disorders, which could be partly explained by improving the gut microbiome compositions and preventing gut leak, and consequently suppressing the inflammation and oxidative damages in both colon and brain.
32305005	9	6	theme	protective	1464:1473	arg1	effects					1475:1481	the protective effects	1460:1481	the protective effects	1460:1481	In conclusion, the TRF and IER but not ADF exhibited the protective effects against colitis and related behavioral disorders, which could be partly explained by improving the gut microbiome compositions and preventing gut leak, and consequently suppressing the inflammation and oxidative damages in both colon and brain.
32305005	9	7	theme	gut	1582:1584	arg1	compositions					1597:1608	the gut microbiome compositions	1578:1608	the gut microbiome compositions	1578:1608	In conclusion, the TRF and IER but not ADF exhibited the protective effects against colitis and related behavioral disorders, which could be partly explained by improving the gut microbiome compositions and preventing gut leak, and consequently suppressing the inflammation and oxidative damages in both colon and brain.
32305005	0	8	theme	colitis	109:115	arg1	disorders					132:140	colitis and behavioral disorders	109:140	colitis and behavioral disorders	109:140	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.
32305005	0	9	from	Effects	0:6	arg1	disorders					132:140	colitis and behavioral disorders	109:140	colitis and behavioral disorders	109:140	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.
32305005	8	10	theme	chain	1363:1367	arg1	acid					1375:1378	the short chain fatty acid	1353:1378	the short chain fatty acid formation in colitis mice	1353:1404	TRF and IER also improved the short chain fatty acid formation in colitis mice.
32305005	10	11	theme	current	1732:1738	arg1	research					1740:1747	The current research	1728:1747	The current research	1728:1747	The current research indicates that proper IF regimens could be effective strategies for nutritional intervention for the prevention and treatment of colitis.
32305005	2	12	theme	energy	495:500	arg1	treatments					406:415	treatments	406:415	treatments	406:415	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	2	12	theme	energy	495:500	arg1	IER					515:517	IER	515:517	IER	515:517	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	2	12	theme	energy	495:500	arg1	restriction					502:512	intermittent energy restriction	482:512	intermittent energy restriction (IER)	482:518	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	3	13	theme	survival	649:656	arg1	rates					658:662	the survival rates	645:662	the survival rates of the colitis mice	645:682	The results indicated that TRF and IER, but not ADF improved the survival rates of the colitis mice.
32305005	4	14	theme	barrier	778:784	arg1	integrity					786:794	the gut barrier integrity	770:794	the gut barrier integrity	770:794	TRF and IER, but not ADF, reversed the colitis pathological development by improving the gut barrier integrity and colon length.
32305005	0	15	theme	behavioral	121:130	arg1	disorders					132:140	colitis and behavioral disorders	109:140	colitis and behavioral disorders	109:140	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.
32305005	6	16	theme	disorder	1013:1020	arg1	behavior					1022:1029	colitis-related anxiety-like and obsessive-compulsive disorder behavior	959:1029	behavior	1022:1029	Interestingly, TRF and IER also attenuated colitis-related anxiety-like and obsessive-compulsive disorder behavior and alleviated the neuroinflammation and oxidative stress.
32305005	5	17	theme	oxidative	881:889	arg1	stress					891:896	oxidative stress	881:896	oxidative stress	881:896	Importantly, TRF and IER suppressed the inflammatory responses and oxidative stress in colon tissues.
32305005	2	18	theme	common	396:401	arg1	effects					369:375	the differential effects	352:375	the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model	352:581	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	2	19	theme	mouse	571:575	arg1	model					577:581	a dextran sodium sulfate (DSS)-induced colitis mouse model	524:581	a dextran sodium sulfate (DSS)-induced colitis mouse model	524:581	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	9	20	theme	gut	1625:1627	arg1	leak					1629:1632	gut leak	1625:1632	gut leak	1625:1632	In conclusion, the TRF and IER but not ADF exhibited the protective effects against colitis and related behavioral disorders, which could be partly explained by improving the gut microbiome compositions and preventing gut leak, and consequently suppressing the inflammation and oxidative damages in both colon and brain.
32305005	2	21	theme	intermittent	482:493	arg1	treatments					406:415	treatments	406:415	treatments	406:415	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	2	21	theme	intermittent	482:493	arg1	IER					515:517	IER	515:517	IER	515:517	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	2	21	theme	intermittent	482:493	arg1	restriction					502:512	intermittent energy restriction	482:512	intermittent energy restriction (IER)	482:518	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	9	22	dep	inflammation	1668:1679	arg1	the					1664:1666	the	1664:1666	the	1664:1666	In conclusion, the TRF and IER but not ADF exhibited the protective effects against colitis and related behavioral disorders, which could be partly explained by improving the gut microbiome compositions and preventing gut leak, and consequently suppressing the inflammation and oxidative damages in both colon and brain.
32305005	8	23	theme	fatty	1369:1373	arg1	acid					1375:1378	the short chain fatty acid	1353:1378	the short chain fatty acid formation in colitis mice	1353:1404	TRF and IER also improved the short chain fatty acid formation in colitis mice.
32305005	2	24	theme	colitis	563:569	arg1	model					577:581	a dextran sodium sulfate (DSS)-induced colitis mouse model	524:581	a dextran sodium sulfate (DSS)-induced colitis mouse model	524:581	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	9	25	theme	related	1503:1509	arg1	disorders					1522:1530	related behavioral disorders	1503:1530	related behavioral disorders	1503:1530	In conclusion, the TRF and IER but not ADF exhibited the protective effects against colitis and related behavioral disorders, which could be partly explained by improving the gut microbiome compositions and preventing gut leak, and consequently suppressing the inflammation and oxidative damages in both colon and brain.
32305005	7	26	theme	gut	1119:1121	arg1	composition					1134:1144	the gut microbiota composition	1115:1144	the gut microbiota composition	1115:1144	TRF and IER also altered the gut microbiota composition, including the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli, and increase of the enrichments of anti-inflammatory-related microbes.
32305005	3	27	theme	colitis	671:677	arg1	mice					679:682	the colitis mice	667:682	the colitis mice	667:682	The results indicated that TRF and IER, but not ADF improved the survival rates of the colitis mice.
32305005	2	28	theme	-induced	554:561	arg1	model					577:581	a dextran sodium sulfate (DSS)-induced colitis mouse model	524:581	a dextran sodium sulfate (DSS)-induced colitis mouse model	524:581	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	2	29	from	effects	369:375	arg1	model					577:581	a dextran sodium sulfate (DSS)-induced colitis mouse model	524:581	a dextran sodium sulfate (DSS)-induced colitis mouse model	524:581	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	9	30	theme	behavioral	1511:1520	arg1	disorders					1522:1530	related behavioral disorders	1503:1530	related behavioral disorders	1503:1530	In conclusion, the TRF and IER but not ADF exhibited the protective effects against colitis and related behavioral disorders, which could be partly explained by improving the gut microbiome compositions and preventing gut leak, and consequently suppressing the inflammation and oxidative damages in both colon and brain.
32305005	10	31	theme	IF	1771:1772	arg1	regimens					1774:1781	proper IF regimens	1764:1781	proper IF regimens	1764:1781	The current research indicates that proper IF regimens could be effective strategies for nutritional intervention for the prevention and treatment of colitis.
32305005	2	32	theme	fasting	432:438	arg1	treatments					406:415	treatments	406:415	treatments	406:415	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	2	32	theme	fasting	432:438	arg1	ADF					441:443	alternate day fasting (ADF)	418:444	alternate day fasting (ADF)	418:444	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	1	33	theme	gut	287:289	arg1	diversity					302:310	the gut microbiome diversity	283:310	the gut microbiome diversity	283:310	Intermittent fasting (IF) has been reported to have beneficial effects on improving gut function via lowering gut inflammation and altering the gut microbiome diversity.
32305005	8	34	theme	short	1357:1361	arg1	acid					1375:1378	the short chain fatty acid	1353:1378	the short chain fatty acid formation in colitis mice	1353:1404	TRF and IER also improved the short chain fatty acid formation in colitis mice.
32305005	8	35	from	formation	1380:1388	arg1	mice					1401:1404	colitis mice	1393:1404	colitis mice	1393:1404	TRF and IER also improved the short chain fatty acid formation in colitis mice.
32305005	1	36	theme	beneficial	195:204	arg1	effects					206:212	beneficial effects	195:212	beneficial effects	195:212	Intermittent fasting (IF) has been reported to have beneficial effects on improving gut function via lowering gut inflammation and altering the gut microbiome diversity.
32305005	2	37	theme	day	428:430	arg1	treatments					406:415	treatments	406:415	treatments	406:415	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	2	37	theme	day	428:430	arg1	ADF					441:443	alternate day fasting (ADF)	418:444	alternate day fasting (ADF)	418:444	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	1	38	theme	microbiome	291:300	arg1	diversity					302:310	the gut microbiome diversity	283:310	the gut microbiome diversity	283:310	Intermittent fasting (IF) has been reported to have beneficial effects on improving gut function via lowering gut inflammation and altering the gut microbiome diversity.
32305005	1	39	contain	have	190:193	arg2	effects					206:212	beneficial effects	195:212	beneficial effects	195:212	Intermittent fasting (IF) has been reported to have beneficial effects on improving gut function via lowering gut inflammation and altering the gut microbiome diversity.
32305005	1	39	contain	have	190:193	arg1	fasting					156:162	Intermittent fasting	143:162	Intermittent fasting (IF)	143:167	Intermittent fasting (IF) has been reported to have beneficial effects on improving gut function via lowering gut inflammation and altering the gut microbiome diversity.
32305005	5	40	theme	inflammatory	854:865	arg1	responses					867:875	the inflammatory responses	850:875	the inflammatory responses	850:875	Importantly, TRF and IER suppressed the inflammatory responses and oxidative stress in colon tissues.
32305005	0	41	theme	time-restricted	34:48	arg1	fasting					50:56	time-restricted fasting	34:56	time-restricted fasting	34:56	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.
32305005	8	42	theme	colitis	1393:1399	arg1	mice					1401:1404	colitis mice	1393:1404	colitis mice	1393:1404	TRF and IER also improved the short chain fatty acid formation in colitis mice.
32305005	10	43	theme	proper	1764:1769	arg1	regimens					1774:1781	proper IF regimens	1764:1781	proper IF regimens	1764:1781	The current research indicates that proper IF regimens could be effective strategies for nutritional intervention for the prevention and treatment of colitis.
32305005	10	44	theme	nutritional	1817:1827	arg1	intervention					1829:1840	nutritional intervention	1817:1840	nutritional intervention	1817:1840	The current research indicates that proper IF regimens could be effective strategies for nutritional intervention for the prevention and treatment of colitis.
32305005	2	45	theme	time-restricted	447:461	arg1	treatments					406:415	treatments	406:415	treatments	406:415	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	2	45	theme	time-restricted	447:461	arg1	TRF					472:474	TRF	472:474	TRF	472:474	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	2	45	theme	time-restricted	447:461	arg1	fasting					463:469	time-restricted fasting	447:469	time-restricted fasting (TRF)	447:475	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	10	46	theme	effective	1792:1800	arg1	strategies					1802:1811	effective strategies	1792:1811	effective strategies for nutritional intervention for the prevention and treatment of colitis	1792:1884	The current research indicates that proper IF regimens could be effective strategies for nutritional intervention for the prevention and treatment of colitis.
32305005	0	47	theme	fasting	25:31	arg1	Effects					0:6	Effects	0:6	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.	0:141	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.
32305005	4	48	theme	colon	800:804	arg1	length					806:811	colon length	800:811	colon length	800:811	TRF and IER, but not ADF, reversed the colitis pathological development by improving the gut barrier integrity and colon length.
32305005	3	49	theme	mice	679:682	arg1	rates					658:662	the survival rates	645:662	the survival rates of the colitis mice	645:682	The results indicated that TRF and IER, but not ADF improved the survival rates of the colitis mice.
32305005	4	50	theme	colitis	724:730	arg1	development					745:755	the colitis pathological development	720:755	the colitis pathological development	720:755	TRF and IER, but not ADF, reversed the colitis pathological development by improving the gut barrier integrity and colon length.
32305005	0	51	theme	fasting	50:56	arg1	Effects					0:6	Effects	0:6	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.	0:141	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.
32305005	10	52	theme	colitis	1878:1884	arg1	treatment					1865:1873	treatment	1865:1873	treatment	1865:1873	The current research indicates that proper IF regimens could be effective strategies for nutritional intervention for the prevention and treatment of colitis.
32305005	10	52	theme	colitis	1878:1884	arg1	prevention					1850:1859	prevention	1850:1859	prevention	1850:1859	The current research indicates that proper IF regimens could be effective strategies for nutritional intervention for the prevention and treatment of colitis.
32305005	4	53	theme	pathological	732:743	arg1	development					745:755	the colitis pathological development	720:755	the colitis pathological development	720:755	TRF and IER, but not ADF, reversed the colitis pathological development by improving the gut barrier integrity and colon length.
32305005	7	54	theme	enrichments	1276:1286	arg1	decrease					1161:1168	the decrease	1157:1168	the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli	1157:1253	TRF and IER also altered the gut microbiota composition, including the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli, and increase of the enrichments of anti-inflammatory-related microbes.
32305005	7	54	theme	enrichments	1276:1286	arg1	increase					1260:1267	increase	1260:1267	increase of the enrichments of anti-inflammatory-related microbes	1260:1324	TRF and IER also altered the gut microbiota composition, including the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli, and increase of the enrichments of anti-inflammatory-related microbes.
32305005	6	55	theme	oxidative	1072:1080	arg1	stress					1082:1087	oxidative stress	1072:1087	oxidative stress	1072:1087	Interestingly, TRF and IER also attenuated colitis-related anxiety-like and obsessive-compulsive disorder behavior and alleviated the neuroinflammation and oxidative stress.
32305005	7	56	theme	anti-inflammatory-related	1291:1315	arg1	microbes					1317:1324	anti-inflammatory-related microbes	1291:1324	anti-inflammatory-related microbes	1291:1324	TRF and IER also altered the gut microbiota composition, including the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli, and increase of the enrichments of anti-inflammatory-related microbes.
32305005	9	57	theme	oxidative	1685:1693	arg1	damages					1695:1701	oxidative damages	1685:1701	oxidative damages	1685:1701	In conclusion, the TRF and IER but not ADF exhibited the protective effects against colitis and related behavioral disorders, which could be partly explained by improving the gut microbiome compositions and preventing gut leak, and consequently suppressing the inflammation and oxidative damages in both colon and brain.
32305005	8	58	theme	acid	1375:1378	arg1	formation					1380:1388	the short chain fatty acid formation	1353:1388	the short chain fatty acid formation in colitis mice	1353:1404	TRF and IER also improved the short chain fatty acid formation in colitis mice.
32305005	7	59	theme	microbes	1317:1324	arg1	enrichments					1276:1286	the enrichments	1272:1286	the enrichments of anti-inflammatory-related microbes	1272:1324	TRF and IER also altered the gut microbiota composition, including the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli, and increase of the enrichments of anti-inflammatory-related microbes.
32305005	1	60	theme	Intermittent	143:154	arg1	fasting					156:162	Intermittent fasting	143:162	Intermittent fasting (IF)	143:167	Intermittent fasting (IF) has been reported to have beneficial effects on improving gut function via lowering gut inflammation and altering the gut microbiome diversity.
32305005	1	61	theme	gut	227:229	arg1	function					231:238	gut function	227:238	gut function	227:238	Intermittent fasting (IF) has been reported to have beneficial effects on improving gut function via lowering gut inflammation and altering the gut microbiome diversity.
32305005	5	62	theme	colon	901:905	arg1	tissues					907:913	colon tissues	901:913	colon tissues	901:913	Importantly, TRF and IER suppressed the inflammatory responses and oxidative stress in colon tissues.
32305005	7	63	theme	microbes	1208:1215	arg1	enrichments					1177:1187	the enrichments	1173:1187	the enrichments of colitis-related microbes such as Shigella and Escherichia Coli	1173:1253	TRF and IER also altered the gut microbiota composition, including the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli, and increase of the enrichments of anti-inflammatory-related microbes.
32305005	9	64	from	damages	1695:1701	arg1	colon					1711:1715	colon	1711:1715	colon	1711:1715	In conclusion, the TRF and IER but not ADF exhibited the protective effects against colitis and related behavioral disorders, which could be partly explained by improving the gut microbiome compositions and preventing gut leak, and consequently suppressing the inflammation and oxidative damages in both colon and brain.
32305005	9	64	from	damages	1695:1701	arg1	brain					1721:1725	brain	1721:1725	brain	1721:1725	In conclusion, the TRF and IER but not ADF exhibited the protective effects against colitis and related behavioral disorders, which could be partly explained by improving the gut microbiome compositions and preventing gut leak, and consequently suppressing the inflammation and oxidative damages in both colon and brain.
32305005	0	65	theme	energy	75:80	arg1	restriction					82:92	intermittent energy restriction DSS-induced	62:104	intermittent energy restriction DSS-induced	62:104	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.
32305005	2	66	theme	alternate	418:426	arg1	treatments					406:415	treatments	406:415	treatments	406:415	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	2	66	theme	alternate	418:426	arg1	ADF					441:443	alternate day fasting (ADF)	418:444	alternate day fasting (ADF)	418:444	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	7	67	theme	colitis-related	1192:1206	arg1	microbes					1208:1215	colitis-related microbes	1192:1215	colitis-related microbes such as Shigella and Escherichia Coli	1192:1253	TRF and IER also altered the gut microbiota composition, including the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli, and increase of the enrichments of anti-inflammatory-related microbes.
32305005	7	67	theme	colitis-related	1192:1206	arg1	Shigella					1225:1232	Shigella	1225:1232	Shigella	1225:1232	TRF and IER also altered the gut microbiota composition, including the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli, and increase of the enrichments of anti-inflammatory-related microbes.
32305005	7	67	theme	colitis-related	1192:1206	arg1	Coli					1250:1253	Escherichia Coli	1238:1253	Escherichia Coli	1238:1253	TRF and IER also altered the gut microbiota composition, including the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli, and increase of the enrichments of anti-inflammatory-related microbes.
32305005	6	68	theme	obsessive-compulsive	992:1011	arg1	behavior					1022:1029	colitis-related anxiety-like and obsessive-compulsive disorder behavior	959:1029	behavior	1022:1029	Interestingly, TRF and IER also attenuated colitis-related anxiety-like and obsessive-compulsive disorder behavior and alleviated the neuroinflammation and oxidative stress.
32305005	9	69	from	inflammation	1668:1679	arg1	colon					1711:1715	colon	1711:1715	colon	1711:1715	In conclusion, the TRF and IER but not ADF exhibited the protective effects against colitis and related behavioral disorders, which could be partly explained by improving the gut microbiome compositions and preventing gut leak, and consequently suppressing the inflammation and oxidative damages in both colon and brain.
32305005	9	69	from	inflammation	1668:1679	arg1	brain					1721:1725	brain	1721:1725	brain	1721:1725	In conclusion, the TRF and IER but not ADF exhibited the protective effects against colitis and related behavioral disorders, which could be partly explained by improving the gut microbiome compositions and preventing gut leak, and consequently suppressing the inflammation and oxidative damages in both colon and brain.
32305005	0	70	theme	intermittent	62:73	arg1	restriction					82:92	intermittent energy restriction DSS-induced	62:104	intermittent energy restriction DSS-induced	62:104	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.
32305005	7	71	theme	microbiota	1123:1132	arg1	composition					1134:1144	the gut microbiota composition	1115:1144	the gut microbiota composition	1115:1144	TRF and IER also altered the gut microbiota composition, including the decrease of the enrichments of colitis-related microbes such as Shigella and Escherichia Coli, and increase of the enrichments of anti-inflammatory-related microbes.
32305005	0	72	theme	alternate-day	11:23	arg1	fasting					25:31	alternate-day fasting	11:31	alternate-day fasting	11:31	Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.
32305005	2	73	theme	differential	356:367	arg1	effects					369:375	the differential effects	352:375	the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model	352:581	In this study, we aimed to investigate the differential effects of three different common IF treatments, alternate day fasting (ADF), time-restricted fasting (TRF), and intermittent energy restriction (IER), on a dextran sodium sulfate (DSS)-induced colitis mouse model.
32305005	10	74	dep	prevention	1850:1859	arg1	the					1846:1848	the	1846:1848	the	1846:1848	The current research indicates that proper IF regimens could be effective strategies for nutritional intervention for the prevention and treatment of colitis.
34890708	10	0	theme	mucus	1678:1682	arg1	penetration					1684:1694	enhanced mucus penetration	1669:1694	enhanced mucus penetration	1669:1694	And the CS/PVA 1:1 group, which presented good enzymatic stability, enhanced mucus penetration and moderate insulin release rate, exhibited the highest relative pharmacological availability of 6.80%.
34890708	2	1	from	degradation	220:230	arg1	mucus					264:268	mucus	264:268	mucus	264:268	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	2	1	from	degradation	220:230	arg1	enterocyte					274:283	enterocyte	274:283	enterocyte	274:283	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	9	2	theme	Spray-dried	1387:1397	arg1	microparticles					1399:1412	Spray-dried microparticles	1387:1412	Spray-dried microparticles	1387:1412	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	6	3	theme	in	857:858	arg1	properties					865:874	the in vitro and in vivo properties	840:874	the in vitro and in vivo properties of the redispersed PEC	840:897	Influence of the CS/PVA ratio on the in vitro and in vivo properties of the redispersed PEC was investigated systemically.
34890708	10	4	theme	insulin	1709:1715	arg1	rate					1725:1728	moderate insulin release rate	1700:1728	moderate insulin release rate	1700:1728	And the CS/PVA 1:1 group, which presented good enzymatic stability, enhanced mucus penetration and moderate insulin release rate, exhibited the highest relative pharmacological availability of 6.80%.
34890708	10	5	theme	highest	1745:1751	arg1	availability					1778:1789	the highest relative pharmacological availability	1741:1789	the highest relative pharmacological availability of 6.80%	1741:1798	And the CS/PVA 1:1 group, which presented good enzymatic stability, enhanced mucus penetration and moderate insulin release rate, exhibited the highest relative pharmacological availability of 6.80%.
34890708	11	6	theme	oral	1919:1922	arg1	delivery					1932:1939	enhanced oral insulin delivery	1910:1939	enhanced oral insulin delivery	1910:1939	In conclusion, PEC in microparticles design using CS/PVA as the composite matrix is a potential platform for enhanced oral insulin delivery.
34890708	5	7	theme	ratio	718:722	arg1	matrix					770:775	the matrix to obtain the microparticles	766:804	the matrix to obtain the microparticles	766:804	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	5	7	theme	ratio	718:722	arg1	CS					734:735	CS	734:735	CS	734:735	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	5	7	theme	ratio	718:722	arg1	chitosan					724:731	different ratio chitosan	708:731	different ratio chitosan (CS)/ polyvinyl alcohol (PVA)	708:761	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	2	8	theme	insulin	329:335	arg1	delivery					337:344	their oral insulin delivery	318:344	their oral insulin delivery	318:344	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	11	9	theme	composite	1865:1873	arg1	matrix					1875:1880	the composite matrix	1861:1880	the composite matrix	1861:1880	In conclusion, PEC in microparticles design using CS/PVA as the composite matrix is a potential platform for enhanced oral insulin delivery.
34890708	11	9	theme	composite	1865:1873	arg1	CS/PVA					1851:1856	CS/PVA	1851:1856	CS/PVA	1851:1856	In conclusion, PEC in microparticles design using CS/PVA as the composite matrix is a potential platform for enhanced oral insulin delivery.
34890708	6	10	from	Influence	807:815	arg1	properties					865:874	the in vitro and in vivo properties	840:874	the in vitro and in vivo properties of the redispersed PEC	840:897	Influence of the CS/PVA ratio on the in vitro and in vivo properties of the redispersed PEC was investigated systemically.
34890708	4	11	theme	PEC	483:485	arg1	microparticles					496:509	PEC embedded microparticles	483:509	PEC embedded microparticles	483:509	Thus, PEC embedded microparticles were fabricated in this study to solve the above dilemma.
34890708	10	12	theme	pharmacological	1762:1776	arg1	availability					1778:1789	the highest relative pharmacological availability	1741:1789	the highest relative pharmacological availability of 6.80%	1741:1798	And the CS/PVA 1:1 group, which presented good enzymatic stability, enhanced mucus penetration and moderate insulin release rate, exhibited the highest relative pharmacological availability of 6.80%.
34890708	7	13	theme	less	1051:1054	arg1	size					1046:1049	particle size	1037:1049	particle size less than 250 nm, and good stability in the gastrointestinal tract	1037:1116	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	7	14	used	used	974:977	arg2	50 kDa					963:968	CS 50 kDa	960:968	CS 50 kDa	960:968	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	6	15	theme	PEC	895:897	arg1	properties					865:874	the in vitro and in vivo properties	840:874	the in vitro and in vivo properties of the redispersed PEC	840:897	Influence of the CS/PVA ratio on the in vitro and in vivo properties of the redispersed PEC was investigated systemically.
34890708	7	16	theme	CS	960:961	arg1	50 kDa					963:968	CS 50 kDa	960:968	CS 50 kDa	960:968	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	1	17	theme	promising	146:154	arg1	nanocomplex					123:133	Polyelectrolyte nanocomplex	107:133	Polyelectrolyte nanocomplex (PEC)	107:139	Polyelectrolyte nanocomplex (PEC) is a promising carrier for insulin encapsulation.
34890708	1	17	theme	promising	146:154	arg1	carrier					156:162	a promising carrier	144:162	a promising carrier for insulin encapsulation	144:188	Polyelectrolyte nanocomplex (PEC) is a promising carrier for insulin encapsulation.
34890708	5	18	dep	chitosan	724:731	arg1	PVA					758:760	PVA	758:760	PVA	758:760	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	5	18	dep	chitosan	724:731	arg1	alcohol					749:755	polyvinyl alcohol	739:755	different ratio chitosan (CS)/ polyvinyl alcohol (PVA)	708:761	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	0	19	theme	oral	84:87	arg1	delivery					97:104	enhanced oral insulin delivery	75:104	enhanced oral insulin delivery	75:104	Exploring the potential of redispersible nanocomplex-in-microparticles for enhanced oral insulin delivery.
34890708	10	20	theme	%	1798:1798	arg1	availability					1778:1789	the highest relative pharmacological availability	1741:1789	the highest relative pharmacological availability of 6.80%	1741:1798	And the CS/PVA 1:1 group, which presented good enzymatic stability, enhanced mucus penetration and moderate insulin release rate, exhibited the highest relative pharmacological availability of 6.80%.
34890708	9	21	theme	PEC	1485:1487	arg1	penetration					1446:1456	the mucus penetration	1436:1456	the mucus penetration of the in situ redispersed PEC	1436:1487	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	9	22	located	observed	1523:1530	arg1	manner					1593:1598	a CS/PVA ratio dependent manner	1568:1598	a CS/PVA ratio dependent manner	1568:1598	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	9	22	located	observed	1523:1530	arg2	permeation					1512:1521	enhanced insulin permeation	1495:1521	enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner	1495:1598	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	9	22	located	observed	1523:1530	arg1	segments					1556:1563	different intestinal segments	1535:1563	different intestinal segments	1535:1563	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	5	23	theme	sodium	607:612	arg1	SDS					631:633	SDS	631:633	SDS	631:633	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	5	23	theme	sodium	607:612	arg1	sulfate					622:628	sodium dodecyl sulfate	607:628	sodium dodecyl sulfate (SDS) coating	607:642	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	9	24	contain	had	1414:1416	arg1	microparticles					1399:1412	Spray-dried microparticles	1387:1412	Spray-dried microparticles	1387:1412	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	9	24	contain	had	1414:1416	arg2	influence					1423:1431	less influence	1418:1431	less influence	1418:1431	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	9	25	dep	in	1465:1466	arg1	situ					1468:1471	situ	1468:1471	situ	1468:1471	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	5	26	theme	sulfate	622:628	arg1	coating					636:642	sodium dodecyl sulfate (SDS) coating	607:642	sodium dodecyl sulfate (SDS) coating	607:642	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	9	27	theme	insulin	1504:1510	arg1	permeation					1512:1521	enhanced insulin permeation	1495:1521	enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner	1495:1598	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	3	28	theme	insulin	368:374	arg1	release					376:382	insulin release	368:382	insulin release	368:382	Besides, the rate of insulin release should be tuned to achieve desired therapeutic effect and meanwhile with scale-up potential.
34890708	7	29	theme	improved	1127:1134	arg1	stability					1146:1154	improved enzymatic stability	1127:1154	improved enzymatic stability	1127:1154	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	5	30	theme	insulin	583:589	arg1	PEC					598:600	insulin loaded PEC	583:600	insulin loaded PEC with sodium dodecyl sulfate (SDS) coating	583:642	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	11	31	from	PEC	1816:1818	arg1	design					1838:1843	microparticles design	1823:1843	microparticles design using CS/PVA as the composite matrix	1823:1880	In conclusion, PEC in microparticles design using CS/PVA as the composite matrix is a potential platform for enhanced oral insulin delivery.
34890708	11	32	theme	potential	1887:1895	arg1	platform					1897:1904	a potential platform	1885:1904	a potential platform for enhanced oral insulin delivery	1885:1939	In conclusion, PEC in microparticles design using CS/PVA as the composite matrix is a potential platform for enhanced oral insulin delivery.
34890708	11	32	theme	potential	1887:1895	arg1	PEC					1816:1818	PEC	1816:1818	PEC in microparticles design using CS/PVA as the composite matrix	1816:1880	In conclusion, PEC in microparticles design using CS/PVA as the composite matrix is a potential platform for enhanced oral insulin delivery.
34890708	10	33	theme	CS/PVA	1609:1614	arg1	group					1620:1624	the CS/PVA 1:1 group	1605:1624	the CS/PVA 1:1 group	1605:1624	And the CS/PVA 1:1 group, which presented good enzymatic stability, enhanced mucus penetration and moderate insulin release rate, exhibited the highest relative pharmacological availability of 6.80%.
34890708	9	34	theme	different	1535:1543	arg1	segments					1556:1563	different intestinal segments	1535:1563	different intestinal segments	1535:1563	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	10	35	theme	good	1643:1646	arg1	stability					1658:1666	good enzymatic stability	1643:1666	good enzymatic stability	1643:1666	And the CS/PVA 1:1 group, which presented good enzymatic stability, enhanced mucus penetration and moderate insulin release rate, exhibited the highest relative pharmacological availability of 6.80%.
34890708	7	36	theme	gastrointestinal	1095:1110	arg1	tract					1112:1116	the gastrointestinal tract	1091:1116	the gastrointestinal tract	1091:1116	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	6	37	theme	in	844:845	arg1	properties					865:874	the in vitro and in vivo properties	840:874	the in vitro and in vivo properties of the redispersed PEC	840:897	Influence of the CS/PVA ratio on the in vitro and in vivo properties of the redispersed PEC was investigated systemically.
34890708	7	38	theme	comparable	1262:1271	arg1	protection					1273:1282	comparable protection	1262:1282	comparable protection	1262:1282	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	8	39	theme	ratio	1359:1363	arg1	increase					1344:1351	the increase	1340:1351	the increase of CS ratio in the CS/PVA matrix	1340:1384	Insulin release from the microparticles decreased with the increase of CS ratio in the CS/PVA matrix.
34890708	0	40	theme	redispersible	27:39	arg1	nanocomplex-in-microparticles					41:69	redispersible nanocomplex-in-microparticles	27:69	redispersible nanocomplex-in-microparticles	27:69	Exploring the potential of redispersible nanocomplex-in-microparticles for enhanced oral insulin delivery.
34890708	3	41	theme	therapeutic	419:429	arg1	effect					431:436	desired therapeutic effect	411:436	desired therapeutic effect	411:436	Besides, the rate of insulin release should be tuned to achieve desired therapeutic effect and meanwhile with scale-up potential.
34890708	7	42	theme	nanoparticles-in-microparticles	1172:1202	arg1	design					1204:1209	nanoparticles-in-microparticles design	1172:1209	nanoparticles-in-microparticles design	1172:1209	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	10	43	theme	enhanced	1669:1676	arg1	penetration					1684:1694	enhanced mucus penetration	1669:1694	enhanced mucus penetration	1669:1694	And the CS/PVA 1:1 group, which presented good enzymatic stability, enhanced mucus penetration and moderate insulin release rate, exhibited the highest relative pharmacological availability of 6.80%.
34890708	7	44	theme	good	1073:1076	arg1	stability					1078:1086	good stability	1073:1086	good stability	1073:1086	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	6	45	theme	CS/PVA	824:829	arg1	ratio					831:835	the CS/PVA ratio	820:835	the CS/PVA ratio	820:835	Influence of the CS/PVA ratio on the in vitro and in vivo properties of the redispersed PEC was investigated systemically.
34890708	8	46	from	microparticles	1310:1323	arg1	release					1293:1299	Insulin release	1285:1299	Insulin release from the microparticles	1285:1323	Insulin release from the microparticles decreased with the increase of CS ratio in the CS/PVA matrix.
34890708	2	47	theme	enzymatic	210:218	arg1	degradation					220:230	tenacious enzymatic degradation	200:230	tenacious enzymatic degradation	200:230	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	2	47	theme	enzymatic	210:218	arg1	obstacles					304:312	the dominating obstacles	289:312	the dominating obstacles for their oral insulin delivery	289:344	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	2	47	theme	enzymatic	210:218	arg1	penetration					249:259	insufficient penetration	236:259	insufficient penetration in mucus and enterocyte	236:283	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	10	48	theme	moderate	1700:1707	arg1	rate					1725:1728	moderate insulin release rate	1700:1728	moderate insulin release rate	1700:1728	And the CS/PVA 1:1 group, which presented good enzymatic stability, enhanced mucus penetration and moderate insulin release rate, exhibited the highest relative pharmacological availability of 6.80%.
34890708	6	49	theme	redispersed	883:893	arg1	PEC					895:897	the redispersed PEC	879:897	the redispersed PEC	879:897	Influence of the CS/PVA ratio on the in vitro and in vivo properties of the redispersed PEC was investigated systemically.
34890708	7	50	theme	CS/PVA	1217:1222	arg1	1:1					1224:1226	CS/PVA 1:1	1217:1226	CS/PVA 1:1	1217:1226	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	6	51	dep	in	857:858	arg1	vivo					860:863	vivo	860:863	vivo	860:863	Influence of the CS/PVA ratio on the in vitro and in vivo properties of the redispersed PEC was investigated systemically.
34890708	8	52	from	increase	1344:1351	arg1	matrix					1379:1384	the CS/PVA matrix	1368:1384	the CS/PVA matrix	1368:1384	Insulin release from the microparticles decreased with the increase of CS ratio in the CS/PVA matrix.
34890708	5	53	theme	self-assembly	660:672	arg1	method					674:679	self-assembly method	660:679	self-assembly method	660:679	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	2	54	theme	oral	324:327	arg1	delivery					337:344	their oral insulin delivery	318:344	their oral insulin delivery	318:344	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	7	55	theme	particle	1037:1044	arg1	size					1046:1049	particle size	1037:1049	particle size less than 250 nm, and good stability in the gastrointestinal tract	1037:1116	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	10	56	theme	release	1717:1723	arg1	rate					1725:1728	moderate insulin release rate	1700:1728	moderate insulin release rate	1700:1728	And the CS/PVA 1:1 group, which presented good enzymatic stability, enhanced mucus penetration and moderate insulin release rate, exhibited the highest relative pharmacological availability of 6.80%.
34890708	6	57	dep	in	844:845	arg1	vitro					847:851	vitro	847:851	vitro	847:851	Influence of the CS/PVA ratio on the in vitro and in vivo properties of the redispersed PEC was investigated systemically.
34890708	10	58	theme	relative	1753:1760	arg1	availability					1778:1789	the highest relative pharmacological availability	1741:1789	the highest relative pharmacological availability of 6.80%	1741:1798	And the CS/PVA 1:1 group, which presented good enzymatic stability, enhanced mucus penetration and moderate insulin release rate, exhibited the highest relative pharmacological availability of 6.80%.
34890708	5	59	with	PEC	598:600	arg1	coating					636:642	sodium dodecyl sulfate (SDS) coating	607:642	sodium dodecyl sulfate (SDS) coating	607:642	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	5	60	theme	different	708:716	arg1	matrix					770:775	the matrix to obtain the microparticles	766:804	the matrix to obtain the microparticles	766:804	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	5	60	theme	different	708:716	arg1	CS					734:735	CS	734:735	CS	734:735	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	5	60	theme	different	708:716	arg1	chitosan					724:731	different ratio chitosan	708:731	different ratio chitosan (CS)/ polyvinyl alcohol (PVA)	708:761	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	11	61	theme	insulin	1924:1930	arg1	delivery					1932:1939	enhanced oral insulin delivery	1910:1939	enhanced oral insulin delivery	1910:1939	In conclusion, PEC in microparticles design using CS/PVA as the composite matrix is a potential platform for enhanced oral insulin delivery.
34890708	9	62	theme	mucus	1440:1444	arg1	penetration					1446:1456	the mucus penetration	1436:1456	the mucus penetration of the in situ redispersed PEC	1436:1487	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	4	63	theme	embedded	487:494	arg1	microparticles					496:509	PEC embedded microparticles	483:509	PEC embedded microparticles	483:509	Thus, PEC embedded microparticles were fabricated in this study to solve the above dilemma.
34890708	11	64	theme	enhanced	1910:1917	arg1	delivery					1932:1939	enhanced oral insulin delivery	1910:1939	enhanced oral insulin delivery	1910:1939	In conclusion, PEC in microparticles design using CS/PVA as the composite matrix is a potential platform for enhanced oral insulin delivery.
34890708	11	65	from	platform	1897:1904	arg1	conclusion					1804:1813	conclusion	1804:1813	conclusion	1804:1813	In conclusion, PEC in microparticles design using CS/PVA as the composite matrix is a potential platform for enhanced oral insulin delivery.
34890708	2	66	theme	dominating	293:302	arg1	degradation					220:230	tenacious enzymatic degradation	200:230	tenacious enzymatic degradation	200:230	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	2	66	theme	dominating	293:302	arg1	obstacles					304:312	the dominating obstacles	289:312	the dominating obstacles for their oral insulin delivery	289:344	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	2	66	theme	dominating	293:302	arg1	penetration					249:259	insufficient penetration	236:259	insufficient penetration in mucus and enterocyte	236:283	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	9	67	theme	in	1465:1466	arg1	PEC					1485:1487	the in situ redispersed PEC	1461:1487	the in situ redispersed PEC	1461:1487	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	0	68	theme	insulin	89:95	arg1	delivery					97:104	enhanced oral insulin delivery	75:104	enhanced oral insulin delivery	75:104	Exploring the potential of redispersible nanocomplex-in-microparticles for enhanced oral insulin delivery.
34890708	9	69	theme	redispersed	1473:1483	arg1	PEC					1485:1487	the in situ redispersed PEC	1461:1487	the in situ redispersed PEC	1461:1487	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	1	70	theme	insulin	168:174	arg1	encapsulation					176:188	insulin encapsulation	168:188	insulin encapsulation	168:188	Polyelectrolyte nanocomplex (PEC) is a promising carrier for insulin encapsulation.
34890708	7	71	from	stability	1078:1086	arg1	tract					1112:1116	the gastrointestinal tract	1091:1116	the gastrointestinal tract	1091:1116	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	8	72	theme	Insulin	1285:1291	arg1	release					1293:1299	Insulin release	1285:1299	Insulin release from the microparticles	1285:1323	Insulin release from the microparticles decreased with the increase of CS ratio in the CS/PVA matrix.
34890708	7	73	theme	enzymatic	1136:1144	arg1	stability					1146:1154	improved enzymatic stability	1127:1154	improved enzymatic stability	1127:1154	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	5	74	theme	dodecyl	614:620	arg1	SDS					631:633	SDS	631:633	SDS	631:633	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	5	74	theme	dodecyl	614:620	arg1	sulfate					622:628	sodium dodecyl sulfate	607:628	sodium dodecyl sulfate (SDS) coating	607:642	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	9	75	theme	enhanced	1495:1502	arg1	permeation					1512:1521	enhanced insulin permeation	1495:1521	enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner	1495:1598	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	2	76	from	penetration	249:259	arg1	mucus					264:268	mucus	264:268	mucus	264:268	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	2	76	from	penetration	249:259	arg1	enterocyte					274:283	enterocyte	274:283	enterocyte	274:283	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	3	77	theme	release	376:382	arg1	rate					360:363	the rate	356:363	the rate of insulin release	356:382	Besides, the rate of insulin release should be tuned to achieve desired therapeutic effect and meanwhile with scale-up potential.
34890708	3	77	theme	release	376:382	arg1	tuned					394:398	tuned	394:398	tuned	394:398	Besides, the rate of insulin release should be tuned to achieve desired therapeutic effect and meanwhile with scale-up potential.
34890708	10	78	theme	1:1	1616:1618	arg1	group					1620:1624	the CS/PVA 1:1 group	1605:1624	the CS/PVA 1:1 group	1605:1624	And the CS/PVA 1:1 group, which presented good enzymatic stability, enhanced mucus penetration and moderate insulin release rate, exhibited the highest relative pharmacological availability of 6.80%.
34890708	5	79	theme	loaded	591:596	arg1	PEC					598:600	insulin loaded PEC	583:600	insulin loaded PEC with sodium dodecyl sulfate (SDS) coating	583:642	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	1	80	theme	Polyelectrolyte	107:121	arg1	nanocomplex					123:133	Polyelectrolyte nanocomplex	107:133	Polyelectrolyte nanocomplex (PEC)	107:139	Polyelectrolyte nanocomplex (PEC) is a promising carrier for insulin encapsulation.
34890708	1	80	theme	Polyelectrolyte	107:121	arg1	carrier					156:162	a promising carrier	144:162	a promising carrier for insulin encapsulation	144:188	Polyelectrolyte nanocomplex (PEC) is a promising carrier for insulin encapsulation.
34890708	1	80	theme	Polyelectrolyte	107:121	arg1	PEC					136:138	PEC	136:138	PEC	136:138	Polyelectrolyte nanocomplex (PEC) is a promising carrier for insulin encapsulation.
34890708	3	81	theme	desired	411:417	arg1	effect					431:436	desired therapeutic effect	411:436	desired therapeutic effect	411:436	Besides, the rate of insulin release should be tuned to achieve desired therapeutic effect and meanwhile with scale-up potential.
34890708	3	82	theme	scale-up	457:464	arg1	potential					466:474	scale-up potential	457:474	scale-up potential	457:474	Besides, the rate of insulin release should be tuned to achieve desired therapeutic effect and meanwhile with scale-up potential.
34890708	9	83	theme	intestinal	1545:1554	arg1	segments					1556:1563	different intestinal segments	1535:1563	different intestinal segments	1535:1563	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	2	84	theme	tenacious	200:208	arg1	degradation					220:230	tenacious enzymatic degradation	200:230	tenacious enzymatic degradation	200:230	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	2	84	theme	tenacious	200:208	arg1	obstacles					304:312	the dominating obstacles	289:312	the dominating obstacles for their oral insulin delivery	289:344	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	2	84	theme	tenacious	200:208	arg1	penetration					249:259	insufficient penetration	236:259	insufficient penetration in mucus and enterocyte	236:283	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	0	85	theme	nanocomplex-in-microparticles	41:69	arg1	potential					14:22	the potential	10:22	the potential of redispersible nanocomplex-in-microparticles for enhanced oral insulin delivery	10:104	Exploring the potential of redispersible nanocomplex-in-microparticles for enhanced oral insulin delivery.
34890708	4	86	theme	above	554:558	arg1	dilemma					560:566	the above dilemma	550:566	the above dilemma	550:566	Thus, PEC embedded microparticles were fabricated in this study to solve the above dilemma.
34890708	8	87	theme	CS	1356:1357	arg1	ratio					1359:1363	CS ratio	1356:1363	CS ratio	1356:1363	Insulin release from the microparticles decreased with the increase of CS ratio in the CS/PVA matrix.
34890708	5	88	theme	polyvinyl	739:747	arg1	PVA					758:760	PVA	758:760	PVA	758:760	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	5	88	theme	polyvinyl	739:747	arg1	alcohol					749:755	polyvinyl alcohol	739:755	different ratio chitosan (CS)/ polyvinyl alcohol (PVA)	708:761	First of all, insulin loaded PEC with sodium dodecyl sulfate (SDS) coating was prepared by self-assembly method and then spray-dried using different ratio chitosan (CS)/ polyvinyl alcohol (PVA) as the matrix to obtain the microparticles.
34890708	0	89	theme	enhanced	75:82	arg1	delivery					97:104	enhanced oral insulin delivery	75:104	enhanced oral insulin delivery	75:104	Exploring the potential of redispersible nanocomplex-in-microparticles for enhanced oral insulin delivery.
34890708	6	90	theme	ratio	831:835	arg1	Influence					807:815	Influence	807:815	Influence of the CS/PVA ratio on the in vitro and in vivo properties of the redispersed PEC	807:897	Influence of the CS/PVA ratio on the in vitro and in vivo properties of the redispersed PEC was investigated systemically.
34890708	7	91	theme	4:1	1232:1234	arg1	groups					1236:1241	CS/PVA 1:1 and 4:1 groups	1217:1241	CS/PVA 1:1 and 4:1 groups showing better and comparable protection	1217:1282	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	7	92	from	250 nm	1061:1066	arg1	tract					1112:1116	the gastrointestinal tract	1091:1116	the gastrointestinal tract	1091:1116	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	2	93	theme	insufficient	236:247	arg1	degradation					220:230	tenacious enzymatic degradation	200:230	tenacious enzymatic degradation	200:230	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	2	93	theme	insufficient	236:247	arg1	penetration					249:259	insufficient penetration	236:259	insufficient penetration in mucus and enterocyte	236:283	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	2	93	theme	insufficient	236:247	arg1	obstacles					304:312	the dominating obstacles	289:312	the dominating obstacles for their oral insulin delivery	289:344	However, tenacious enzymatic degradation and insufficient penetration in mucus and enterocyte are the dominating obstacles for their oral insulin delivery.
34890708	11	94	theme	microparticles	1823:1836	arg1	design					1838:1843	microparticles design	1823:1843	microparticles design using CS/PVA as the composite matrix	1823:1880	In conclusion, PEC in microparticles design using CS/PVA as the composite matrix is a potential platform for enhanced oral insulin delivery.
34890708	9	95	theme	dependent	1583:1591	arg1	manner					1593:1598	a CS/PVA ratio dependent manner	1568:1598	a CS/PVA ratio dependent manner	1568:1598	Spray-dried microparticles had less influence on the mucus penetration of the in situ redispersed PEC, with enhanced insulin permeation observed in different intestinal segments in a CS/PVA ratio dependent manner.
34890708	7	96	theme	1:1	1224:1226	arg1	groups					1236:1241	CS/PVA 1:1 and 4:1 groups	1217:1241	CS/PVA 1:1 and 4:1 groups showing better and comparable protection	1217:1282	It was demonstrated that when CS 50 kDa was used in the matrix, all the PEC could be well redispersed with particle size less than 250 nm, and good stability in the gastrointestinal tract, further improved enzymatic stability was achieved by nanoparticles-in-microparticles design, with CS/PVA 1:1 and 4:1 groups showing better and comparable protection.
34890708	8	97	theme	CS/PVA	1372:1377	arg1	matrix					1379:1384	the CS/PVA matrix	1368:1384	the CS/PVA matrix	1368:1384	Insulin release from the microparticles decreased with the increase of CS ratio in the CS/PVA matrix.
34890708	10	98	theme	enzymatic	1648:1656	arg1	stability					1658:1666	good enzymatic stability	1643:1666	good enzymatic stability	1643:1666	And the CS/PVA 1:1 group, which presented good enzymatic stability, enhanced mucus penetration and moderate insulin release rate, exhibited the highest relative pharmacological availability of 6.80%.
34517106	0	0	theme	neural	108:113	arg1	cells					126:130	neural progenitor cells	108:130	neural progenitor cells	108:130	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels promote the differentiation of neural progenitor cells in 3D towards oligodendrocytes in vitro.
34517106	1	1	from	culture	196:202	arg1	hydrogels					241:249	hydrogels	241:249	hydrogels	241:249	Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels represents a powerful means for recapitulating neurodevelopment, disease modelling and drug discovery.
34517106	5	2	theme	mouse	879:883	arg1	NPCs					885:888	mouse NPCs	879:888	mouse NPCs	879:888	In addition, the composite hydrogels were biocompatible with mouse NPCs and improved the proliferation of the encapsulated NPCs compared with SA hydrogels.
34517106	7	3	theme	suitable	1345:1352	arg1	scaffold					1354:1361	a suitable scaffold	1343:1361	a suitable scaffold for the construction of neural tissue engineering and neurological disease modelling	1343:1446	The present composite hydrogels provide a suitable scaffold for the construction of neural tissue engineering and neurological disease modelling.
34517106	3	4	theme	SA	512:513	arg1	hydrogels					526:534	polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels	469:534	polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D	469:565	In this study, polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D were fabricated by ionic crosslinking between SA and calcium ions.
34517106	1	5	theme	powerful	264:271	arg1	means					273:277	a powerful means	262:277	a powerful means for recapitulating neurodevelopment, disease modelling and drug discovery	262:351	Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels represents a powerful means for recapitulating neurodevelopment, disease modelling and drug discovery.
34517106	0	6	theme	cells	126:130	arg1	differentiation					89:103	the differentiation	85:103	the differentiation of neural progenitor cells in 3D towards oligodendrocytes	85:161	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels promote the differentiation of neural progenitor cells in 3D towards oligodendrocytes in vitro.
34517106	4	7	theme	elastic	767:773	arg1	moduli					775:780	elastic moduli	767:780	elastic moduli	767:780	It was demonstrated that adding PVA to the composite hydrogels resulted in increases in pore size and swelling rate and decreases in elastic moduli as the PVA proportion was enhanced.
34517106	5	8	with	biocompatible	860:872	arg1	NPCs					885:888	mouse NPCs	879:888	mouse NPCs	879:888	In addition, the composite hydrogels were biocompatible with mouse NPCs and improved the proliferation of the encapsulated NPCs compared with SA hydrogels.
34517106	4	9	from	decreases	754:762	arg1	size					727:730	pore size	722:730	pore size	722:730	It was demonstrated that adding PVA to the composite hydrogels resulted in increases in pore size and swelling rate and decreases in elastic moduli as the PVA proportion was enhanced.
34517106	4	9	from	decreases	754:762	arg1	rate					745:748	swelling rate	736:748	swelling rate	736:748	It was demonstrated that adding PVA to the composite hydrogels resulted in increases in pore size and swelling rate and decreases in elastic moduli as the PVA proportion was enhanced.
34517106	4	9	from	decreases	754:762	arg1	moduli					775:780	elastic moduli	767:780	elastic moduli	767:780	It was demonstrated that adding PVA to the composite hydrogels resulted in increases in pore size and swelling rate and decreases in elastic moduli as the PVA proportion was enhanced.
34517106	7	10	theme	disease	1430:1436	arg1	modelling					1438:1446	neurological disease modelling	1417:1446	neurological disease modelling	1417:1446	The present composite hydrogels provide a suitable scaffold for the construction of neural tissue engineering and neurological disease modelling.
34517106	5	11	theme	NPCs	941:944	arg1	proliferation					907:919	the proliferation	903:919	the proliferation of the encapsulated NPCs	903:944	In addition, the composite hydrogels were biocompatible with mouse NPCs and improved the proliferation of the encapsulated NPCs compared with SA hydrogels.
34517106	0	12	theme	progenitor	115:124	arg1	cells					126:130	neural progenitor cells	108:130	neural progenitor cells	108:130	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels promote the differentiation of neural progenitor cells in 3D towards oligodendrocytes in vitro.
34517106	5	13	from	biocompatible	860:872	arg1	addition					821:828	addition	821:828	addition	821:828	In addition, the composite hydrogels were biocompatible with mouse NPCs and improved the proliferation of the encapsulated NPCs compared with SA hydrogels.
34517106	3	14	theme	NPC	549:551	arg1	culture					553:559	NPC culture	549:559	NPC culture	549:559	In this study, polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D were fabricated by ionic crosslinking between SA and calcium ions.
34517106	4	15	theme	composite	677:685	arg1	hydrogels					687:695	the composite hydrogels	673:695	the composite hydrogels	673:695	It was demonstrated that adding PVA to the composite hydrogels resulted in increases in pore size and swelling rate and decreases in elastic moduli as the PVA proportion was enhanced.
34517106	2	16	theme	great	437:441	arg1	challenge					443:451	a great challenge	435:451	a great challenge	435:451	However, the differentiation of NPCs to oligodendrocytes in 3D scaffolds remains a great challenge.
34517106	5	17	theme	SA	960:961	arg1	hydrogels					963:971	SA hydrogels	960:971	SA hydrogels	960:971	In addition, the composite hydrogels were biocompatible with mouse NPCs and improved the proliferation of the encapsulated NPCs compared with SA hydrogels.
34517106	7	18	theme	present	1307:1313	arg1	hydrogels					1325:1333	The present composite hydrogels	1303:1333	The present composite hydrogels	1303:1333	The present composite hydrogels provide a suitable scaffold for the construction of neural tissue engineering and neurological disease modelling.
34517106	7	19	theme	neurological	1417:1428	arg1	modelling					1438:1446	neurological disease modelling	1417:1446	neurological disease modelling	1417:1446	The present composite hydrogels provide a suitable scaffold for the construction of neural tissue engineering and neurological disease modelling.
34517106	2	20	theme	3D	414:415	arg1	scaffolds					417:425	3D scaffolds	414:425	3D scaffolds	414:425	However, the differentiation of NPCs to oligodendrocytes in 3D scaffolds remains a great challenge.
34517106	0	21	theme	antler	7:12	arg1	hydrogels					67:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels	0:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels	0:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels promote the differentiation of neural progenitor cells in 3D towards oligodendrocytes in vitro.
34517106	3	22	theme	composite	516:524	arg1	hydrogels					526:534	polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels	469:534	polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D	469:565	In this study, polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D were fabricated by ionic crosslinking between SA and calcium ions.
34517106	7	23	theme	tissue	1394:1399	arg1	engineering					1401:1411	neural tissue engineering	1387:1411	neural tissue engineering	1387:1411	The present composite hydrogels provide a suitable scaffold for the construction of neural tissue engineering and neurological disease modelling.
34517106	0	24	theme	Velvet	0:5	arg1	hydrogels					67:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels	0:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels	0:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels promote the differentiation of neural progenitor cells in 3D towards oligodendrocytes in vitro.
34517106	4	25	theme	pore	722:725	arg1	size					727:730	pore size	722:730	pore size	722:730	It was demonstrated that adding PVA to the composite hydrogels resulted in increases in pore size and swelling rate and decreases in elastic moduli as the PVA proportion was enhanced.
34517106	1	26	theme	neural	207:212	arg1	cells					225:229	neural progenitor cells	207:229	neural progenitor cells (NPCs)	207:236	Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels represents a powerful means for recapitulating neurodevelopment, disease modelling and drug discovery.
34517106	1	26	theme	neural	207:212	arg1	NPCs					232:235	NPCs	232:235	NPCs	232:235	Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels represents a powerful means for recapitulating neurodevelopment, disease modelling and drug discovery.
34517106	0	27	theme	polyvinyl	33:41	arg1	hydrogels					67:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels	0:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels	0:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels promote the differentiation of neural progenitor cells in 3D towards oligodendrocytes in vitro.
34517106	7	28	theme	engineering	1401:1411	arg1	modelling					1438:1446	neurological disease modelling	1417:1446	neurological disease modelling	1417:1446	The present composite hydrogels provide a suitable scaffold for the construction of neural tissue engineering and neurological disease modelling.
34517106	7	28	theme	engineering	1401:1411	arg1	construction					1371:1382	the construction	1367:1382	the construction of neural tissue engineering	1367:1411	The present composite hydrogels provide a suitable scaffold for the construction of neural tissue engineering and neurological disease modelling.
34517106	4	29	theme	swelling	736:743	arg1	rate					745:748	swelling rate	736:748	swelling rate	736:748	It was demonstrated that adding PVA to the composite hydrogels resulted in increases in pore size and swelling rate and decreases in elastic moduli as the PVA proportion was enhanced.
34517106	1	30	theme	progenitor	214:223	arg1	cells					225:229	neural progenitor cells	207:229	neural progenitor cells (NPCs)	207:236	Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels represents a powerful means for recapitulating neurodevelopment, disease modelling and drug discovery.
34517106	1	30	theme	progenitor	214:223	arg1	NPCs					232:235	NPCs	232:235	NPCs	232:235	Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels represents a powerful means for recapitulating neurodevelopment, disease modelling and drug discovery.
34517106	0	31	theme	polypeptide-loaded	14:31	arg1	hydrogels					67:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels	0:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels	0:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels promote the differentiation of neural progenitor cells in 3D towards oligodendrocytes in vitro.
34517106	6	32	theme	PVA-SA	1135:1140	arg1	hydrogels					1142:1150	PVA-SA hydrogels	1135:1150	PVA-SA hydrogels	1135:1150	Moreover, when velvet antler polypeptides (VAPs), which were capable of facilitating the differentiation of NPCs to oligodendrocyte fate in 2D, were loaded into PVA-SA hydrogels, NPCs differentiated into neurons, astrocytes and oligodendrocytes, with the presence of VAPs promoting oligodendrogenesis in a dose-dependant manner.
34517106	1	33	dep	Three-dimensional	173:189	arg1	3D					192:193	3D	192:193	3D	192:193	Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels represents a powerful means for recapitulating neurodevelopment, disease modelling and drug discovery.
34517106	1	34	theme	cells	225:229	arg1	culture					196:202	Three-dimensional (3D) culture	173:202	Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels	173:249	Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels represents a powerful means for recapitulating neurodevelopment, disease modelling and drug discovery.
34517106	0	35	theme	alginate	58:65	arg1	hydrogels					67:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels	0:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels	0:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels promote the differentiation of neural progenitor cells in 3D towards oligodendrocytes in vitro.
34517106	1	36	theme	disease	316:322	arg1	modelling					324:332	disease modelling	316:332	disease modelling	316:332	Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels represents a powerful means for recapitulating neurodevelopment, disease modelling and drug discovery.
34517106	3	37	theme	ionic	586:590	arg1	crosslinking					592:603	ionic crosslinking	586:603	ionic crosslinking between SA and calcium ions	586:631	In this study, polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D were fabricated by ionic crosslinking between SA and calcium ions.
34517106	0	38	theme	alcohol-sodium	43:56	arg1	hydrogels					67:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels	0:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels	0:75	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels promote the differentiation of neural progenitor cells in 3D towards oligodendrocytes in vitro.
34517106	0	39	from	differentiation	89:103	arg1	3D					135:136	3D	135:136	3D	135:136	Velvet antler polypeptide-loaded polyvinyl alcohol-sodium alginate hydrogels promote the differentiation of neural progenitor cells in 3D towards oligodendrocytes in vitro.
34517106	4	40	theme	PVA	789:791	arg1	proportion					793:802	the PVA proportion	785:802	the PVA proportion	785:802	It was demonstrated that adding PVA to the composite hydrogels resulted in increases in pore size and swelling rate and decreases in elastic moduli as the PVA proportion was enhanced.
34517106	5	41	from	addition	821:828	arg1	biocompatible					860:872	biocompatible	860:872	biocompatible	860:872	In addition, the composite hydrogels were biocompatible with mouse NPCs and improved the proliferation of the encapsulated NPCs compared with SA hydrogels.
34517106	5	41	from	addition	821:828	arg1	hydrogels					845:853	the composite hydrogels	831:853	the composite hydrogels	831:853	In addition, the composite hydrogels were biocompatible with mouse NPCs and improved the proliferation of the encapsulated NPCs compared with SA hydrogels.
34517106	3	42	theme	polyvinyl	469:477	arg1	PVA					488:490	PVA	488:490	PVA	488:490	In this study, polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D were fabricated by ionic crosslinking between SA and calcium ions.
34517106	3	42	theme	polyvinyl	469:477	arg1	alcohol					479:485	polyvinyl alcohol	469:485	polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D	469:565	In this study, polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D were fabricated by ionic crosslinking between SA and calcium ions.
34517106	2	43	from	oligodendrocytes	394:409	arg1	scaffolds					417:425	3D scaffolds	414:425	3D scaffolds	414:425	However, the differentiation of NPCs to oligodendrocytes in 3D scaffolds remains a great challenge.
34517106	3	44	theme	 - sodium	492:500	arg1	hydrogels					526:534	polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels	469:534	polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D	469:565	In this study, polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D were fabricated by ionic crosslinking between SA and calcium ions.
34517106	5	45	theme	encapsulated	928:939	arg1	NPCs					941:944	the encapsulated NPCs	924:944	the encapsulated NPCs	924:944	In addition, the composite hydrogels were biocompatible with mouse NPCs and improved the proliferation of the encapsulated NPCs compared with SA hydrogels.
34517106	1	46	theme	drug	338:341	arg1	discovery					343:351	drug discovery	338:351	drug discovery	338:351	Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels represents a powerful means for recapitulating neurodevelopment, disease modelling and drug discovery.
34517106	6	47	theme	dose-dependant	1280:1293	arg1	manner					1295:1300	a dose-dependant manner	1278:1300	a dose-dependant manner	1278:1300	Moreover, when velvet antler polypeptides (VAPs), which were capable of facilitating the differentiation of NPCs to oligodendrocyte fate in 2D, were loaded into PVA-SA hydrogels, NPCs differentiated into neurons, astrocytes and oligodendrocytes, with the presence of VAPs promoting oligodendrogenesis in a dose-dependant manner.
34517106	7	48	theme	composite	1315:1323	arg1	hydrogels					1325:1333	The present composite hydrogels	1303:1333	The present composite hydrogels	1303:1333	The present composite hydrogels provide a suitable scaffold for the construction of neural tissue engineering and neurological disease modelling.
34517106	3	49	theme	alginate	502:509	arg1	hydrogels					526:534	polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels	469:534	polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D	469:565	In this study, polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D were fabricated by ionic crosslinking between SA and calcium ions.
34517106	6	50	theme	oligodendrocyte	1090:1104	arg1	fate					1106:1109	oligodendrocyte fate	1090:1109	oligodendrocyte fate	1090:1109	Moreover, when velvet antler polypeptides (VAPs), which were capable of facilitating the differentiation of NPCs to oligodendrocyte fate in 2D, were loaded into PVA-SA hydrogels, NPCs differentiated into neurons, astrocytes and oligodendrocytes, with the presence of VAPs promoting oligodendrogenesis in a dose-dependant manner.
34517106	4	51	from	increases	709:717	arg1	size					727:730	pore size	722:730	pore size	722:730	It was demonstrated that adding PVA to the composite hydrogels resulted in increases in pore size and swelling rate and decreases in elastic moduli as the PVA proportion was enhanced.
34517106	4	51	from	increases	709:717	arg1	rate					745:748	swelling rate	736:748	swelling rate	736:748	It was demonstrated that adding PVA to the composite hydrogels resulted in increases in pore size and swelling rate and decreases in elastic moduli as the PVA proportion was enhanced.
34517106	4	51	from	increases	709:717	arg1	moduli					775:780	elastic moduli	767:780	elastic moduli	767:780	It was demonstrated that adding PVA to the composite hydrogels resulted in increases in pore size and swelling rate and decreases in elastic moduli as the PVA proportion was enhanced.
34517106	7	52	theme	neural	1387:1392	arg1	engineering					1401:1411	neural tissue engineering	1387:1411	neural tissue engineering	1387:1411	The present composite hydrogels provide a suitable scaffold for the construction of neural tissue engineering and neurological disease modelling.
34517106	3	53	theme	calcium	620:626	arg1	ions					628:631	SA and calcium ions	613:631	ions	628:631	In this study, polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D were fabricated by ionic crosslinking between SA and calcium ions.
34517106	1	54	theme	Three-dimensional	173:189	arg1	culture					196:202	Three-dimensional (3D) culture	173:202	Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels	173:249	Three-dimensional (3D) culture of neural progenitor cells (NPCs) in hydrogels represents a powerful means for recapitulating neurodevelopment, disease modelling and drug discovery.
34517106	3	55	theme	alcohol	479:485	arg1	hydrogels					526:534	polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels	469:534	polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D	469:565	In this study, polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D were fabricated by ionic crosslinking between SA and calcium ions.
34517106	6	56	theme	NPCs	1082:1085	arg1	differentiation					1063:1077	the differentiation	1059:1077	the differentiation of NPCs to oligodendrocyte fate	1059:1109	Moreover, when velvet antler polypeptides (VAPs), which were capable of facilitating the differentiation of NPCs to oligodendrocyte fate in 2D, were loaded into PVA-SA hydrogels, NPCs differentiated into neurons, astrocytes and oligodendrocytes, with the presence of VAPs promoting oligodendrogenesis in a dose-dependant manner.
34517106	5	57	theme	composite	835:843	arg1	biocompatible					860:872	biocompatible	860:872	biocompatible	860:872	In addition, the composite hydrogels were biocompatible with mouse NPCs and improved the proliferation of the encapsulated NPCs compared with SA hydrogels.
34517106	5	57	theme	composite	835:843	arg1	hydrogels					845:853	the composite hydrogels	831:853	the composite hydrogels	831:853	In addition, the composite hydrogels were biocompatible with mouse NPCs and improved the proliferation of the encapsulated NPCs compared with SA hydrogels.
34517106	6	58	theme	antler	996:1001	arg1	VAPs					1017:1020	VAPs	1017:1020	VAPs	1017:1020	Moreover, when velvet antler polypeptides (VAPs), which were capable of facilitating the differentiation of NPCs to oligodendrocyte fate in 2D, were loaded into PVA-SA hydrogels, NPCs differentiated into neurons, astrocytes and oligodendrocytes, with the presence of VAPs promoting oligodendrogenesis in a dose-dependant manner.
34517106	6	58	theme	antler	996:1001	arg1	polypeptides					1003:1014	velvet antler polypeptides	989:1014	velvet antler polypeptides (VAPs)	989:1021	Moreover, when velvet antler polypeptides (VAPs), which were capable of facilitating the differentiation of NPCs to oligodendrocyte fate in 2D, were loaded into PVA-SA hydrogels, NPCs differentiated into neurons, astrocytes and oligodendrocytes, with the presence of VAPs promoting oligodendrogenesis in a dose-dependant manner.
34517106	3	59	theme	SA	613:614	arg1	ions					628:631	SA and calcium ions	613:631	ions	628:631	In this study, polyvinyl alcohol (PVA) - sodium alginate (SA) composite hydrogels intended for NPC culture in 3D were fabricated by ionic crosslinking between SA and calcium ions.
34517106	2	60	theme	NPCs	386:389	arg1	differentiation					367:381	the differentiation	363:381	the differentiation of NPCs to oligodendrocytes in 3D scaffolds	363:425	However, the differentiation of NPCs to oligodendrocytes in 3D scaffolds remains a great challenge.
34517106	6	61	theme	VAPs	1241:1244	arg1	presence					1229:1236	the presence	1225:1236	the presence of VAPs promoting oligodendrogenesis in a dose-dependant manner	1225:1300	Moreover, when velvet antler polypeptides (VAPs), which were capable of facilitating the differentiation of NPCs to oligodendrocyte fate in 2D, were loaded into PVA-SA hydrogels, NPCs differentiated into neurons, astrocytes and oligodendrocytes, with the presence of VAPs promoting oligodendrogenesis in a dose-dependant manner.
34517106	6	62	theme	velvet	989:994	arg1	VAPs					1017:1020	VAPs	1017:1020	VAPs	1017:1020	Moreover, when velvet antler polypeptides (VAPs), which were capable of facilitating the differentiation of NPCs to oligodendrocyte fate in 2D, were loaded into PVA-SA hydrogels, NPCs differentiated into neurons, astrocytes and oligodendrocytes, with the presence of VAPs promoting oligodendrogenesis in a dose-dependant manner.
34517106	6	62	theme	velvet	989:994	arg1	polypeptides					1003:1014	velvet antler polypeptides	989:1014	velvet antler polypeptides (VAPs)	989:1021	Moreover, when velvet antler polypeptides (VAPs), which were capable of facilitating the differentiation of NPCs to oligodendrocyte fate in 2D, were loaded into PVA-SA hydrogels, NPCs differentiated into neurons, astrocytes and oligodendrocytes, with the presence of VAPs promoting oligodendrogenesis in a dose-dependant manner.
34069393	0	0	theme	Antiproliferative	103:119	arg1	Properties					121:130	Adequate Mechanical and Antiproliferative Properties	79:130	Adequate Mechanical and Antiproliferative Properties	79:130	Ultrasound-Assisted Water Extraction of Mastocarpus stellatus Carrageenan with Adequate Mechanical and Antiproliferative Properties.
34069393	2	1	theme	carrageenan	536:546	arg1	fraction					548:555	the carrageenan fraction	532:555	the carrageenan fraction	532:555	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	6	2	theme	soluble	1243:1249	arg1	extract					1251:1257	The dried soluble extract	1233:1257	The dried soluble extract	1233:1257	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	5	3	theme	cancer	1147:1152	arg1	HeLa					1185:1188	HeLa 229	1185:1192	HeLa 229	1185:1192	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	3	theme	cancer	1147:1152	arg1	A-549					1170:1174	A-549	1170:1174	A-549	1170:1174	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	3	theme	cancer	1147:1152	arg1	A-2780					1177:1182	A-2780	1177:1182	A-2780	1177:1182	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	3	theme	cancer	1147:1152	arg1	HT-29					1199:1203	HT-29	1199:1203	HT-29	1199:1203	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	3	theme	cancer	1147:1152	arg1	lines					1163:1167	selected human cancer cellular lines	1132:1167	selected human cancer cellular lines	1132:1167	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	2	4	theme	ultrasound	401:410	arg1	amplitude					412:420	ultrasound amplitude	401:420	ultrasound amplitude	401:420	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	6	5	contain	contained	1259:1267	arg1	extract					1251:1257	The dried soluble extract	1233:1257	The dried soluble extract	1233:1257	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	6	5	contain	contained	1259:1267	arg2	protein/g					1277:1285	20.4 mg protein/g	1269:1285	20.4 mg protein/g	1269:1285	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	6	5	contain	contained	1259:1267	arg2	eq/g					1308:1311	11.3 mg gallic acid eq/g	1288:1311	11.3 mg gallic acid eq/g	1288:1311	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	5	6	theme	antiproliferative	1100:1116	arg1	properties					1118:1127	promising antiproliferative properties	1090:1127	promising antiproliferative properties	1090:1127	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	6	7	theme	dried	1237:1241	arg1	extract					1251:1257	The dried soluble extract	1233:1257	The dried soluble extract	1233:1257	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	4	8	theme	40.3	865:868	arg1	%					869:869	%	869:869	%	869:869	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	4	9	theme	%	931:931	arg1	sulfate					933:939	46% sulfate	929:939	46% sulfate	929:939	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	4	10	theme	%	869:869	arg1	yield					883:887	40.3% carrageenan yield	865:887	40.3% carrageenan yield	865:887	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	4	11	theme	gelling	1025:1031	arg1	temperatures					1033:1044	the lowest gelling temperatures	1014:1044	the lowest gelling temperatures of 39.4 °C	1014:1055	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	3	12	theme	ultrasound	811:820	arg1	amplitude					822:830	ultrasound amplitude	811:830	ultrasound amplitude of ~79%	811:838	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	2	13	dep	composition	573:583	arg1	protein					586:592	protein	586:592	protein	586:592	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	13	dep	composition	573:583	arg1	content					607:613	phenolic content	598:613	phenolic content	598:613	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	14	theme	antiradical	620:630	arg1	capacity					632:639	antiradical capacity	620:639	antiradical capacity of the soluble extracts	620:663	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	15	theme	solid	377:381	arg1	ratio					390:394	solid liquid ratio	377:394	solid liquid ratio	377:394	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	6	16	theme	acid	1303:1306	arg1	eq/g					1308:1311	11.3 mg gallic acid eq/g	1288:1311	11.3 mg gallic acid eq/g	1288:1311	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	6	16	theme	acid	1303:1306	arg1	protein/g					1277:1285	20.4 mg protein/g	1269:1285	20.4 mg protein/g	1269:1285	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	3	17	theme	%	838:838	arg1	amplitude					822:830	ultrasound amplitude	811:830	ultrasound amplitude of ~79%	811:838	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	3	17	theme	%	838:838	arg1	conditions					750:759	optimum extraction conditions	731:759	optimum extraction conditions at ~35 min	731:770	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	3	17	theme	%	838:838	arg1	ratio					786:790	solid liquid ratio	773:790	solid liquid ratio of ~2 g/100 g	773:804	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	1	18	theme	antioxidant	219:229	arg1	compounds					231:239	antioxidant compounds	219:239	antioxidant compounds	219:239	Ultrasound-assisted water extraction was optimized to recover gelling biopolymers and antioxidant compounds from Mastocarpus stellatus.
34069393	2	19	theme	gelling	508:514	arg1	temperature					516:526	gelling temperature	508:526	gelling temperature	508:526	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	19	theme	gelling	508:514	arg1	properties					476:485	thermo-rheological properties	457:485	thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction	457:555	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	3	20	theme	optimum	731:737	arg1	conditions					750:759	optimum extraction conditions	731:759	optimum extraction conditions at ~35 min	731:770	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	2	21	dep	properties	476:485	arg1	viscoelasticity					488:502	viscoelasticity	488:502	viscoelasticity	488:502	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	21	dep	properties	476:485	arg1	temperature					516:526	gelling temperature	508:526	gelling temperature	508:526	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	21	dep	properties	476:485	arg1	properties					476:485	thermo-rheological properties	457:485	thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction	457:555	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	6	22	theme	59	1360:1361	arg1	mg					1363:1364	mg	1363:1364	mg	1363:1364	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	3	23	from	min	768:770	arg1	amplitude					822:830	ultrasound amplitude	811:830	ultrasound amplitude of ~79%	811:838	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	3	23	from	min	768:770	arg1	conditions					750:759	optimum extraction conditions	731:759	optimum extraction conditions at ~35 min	731:770	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	3	23	from	min	768:770	arg1	ratio					786:790	solid liquid ratio	773:790	solid liquid ratio of ~2 g/100 g	773:804	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	0	24	theme	Water	20:24	arg1	Extraction					26:35	Ultrasound-Assisted Water Extraction	0:35	Ultrasound-Assisted Water Extraction of Mastocarpus stellatus Carrageenan with Adequate Mechanical and Antiproliferative Properties	0:130	Ultrasound-Assisted Water Extraction of Mastocarpus stellatus Carrageenan with Adequate Mechanical and Antiproliferative Properties.
34069393	3	25	theme	extraction	739:748	arg1	conditions					750:759	optimum extraction conditions	731:759	optimum extraction conditions at ~35 min	731:770	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	2	26	theme	extracts	656:663	arg1	properties					476:485	thermo-rheological properties	457:485	thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction	457:555	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	26	theme	extracts	656:663	arg1	viscoelasticity					488:502	viscoelasticity	488:502	viscoelasticity	488:502	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	26	theme	extracts	656:663	arg1	content					444:450	sulfate content	436:450	sulfate content	436:450	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	26	theme	extracts	656:663	arg1	capacity					632:639	antiradical capacity	620:639	antiradical capacity of the soluble extracts	620:663	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	26	theme	extracts	656:663	arg1	composition					573:583	the composition	569:583	the composition (protein and phenolic content)	569:614	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	26	theme	extracts	656:663	arg1	temperature					516:526	gelling temperature	508:526	gelling temperature	508:526	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	26	theme	extracts	656:663	arg1	yield					429:433	the yield	425:433	the yield	425:433	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	4	27	theme	mechanical	950:959	arg1	modulus					988:994	a viscoelastic modulus	973:994	a viscoelastic modulus of 741.4 Pa	973:1006	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	4	27	theme	mechanical	950:959	arg1	properties					961:970	good mechanical properties	945:970	good mechanical properties	945:970	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	6	28	theme	20.4	1269:1272	arg1	mg					1274:1275	mg	1274:1275	mg	1274:1275	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	0	29	theme	Ultrasound-Assisted	0:18	arg1	Extraction					26:35	Ultrasound-Assisted Water Extraction	0:35	Ultrasound-Assisted Water Extraction of Mastocarpus stellatus Carrageenan with Adequate Mechanical and Antiproliferative Properties	0:130	Ultrasound-Assisted Water Extraction of Mastocarpus stellatus Carrageenan with Adequate Mechanical and Antiproliferative Properties.
34069393	2	30	theme	soluble	648:654	arg1	extracts					656:663	the soluble extracts	644:663	the soluble extracts	644:663	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	31	theme	time	371:374	arg1	influence					347:355	the influence	343:355	the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts	343:663	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	6	32	theme	11.3	1288:1291	arg1	mg					1293:1294	mg	1293:1294	mg	1293:1294	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	3	33	theme	solid	773:777	arg1	ratio					786:790	solid liquid ratio	773:790	solid liquid ratio of ~2 g/100 g	773:804	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	6	34	theme	mg	1293:1294	arg1	acid					1303:1306	11.3 mg gallic acid	1288:1306	11.3 mg gallic acid eq/g	1288:1311	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	2	35	theme	extraction	360:369	arg1	time					371:374	extraction time	360:374	extraction time	360:374	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	36	theme	thermo-rheological	457:474	arg1	viscoelasticity					488:502	viscoelasticity	488:502	viscoelasticity	488:502	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	36	theme	thermo-rheological	457:474	arg1	temperature					516:526	gelling temperature	508:526	gelling temperature	508:526	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	36	theme	thermo-rheological	457:474	arg1	properties					476:485	thermo-rheological properties	457:485	thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction	457:555	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	6	37	theme	mg	1363:1364	arg1	Trolox/g					1366:1373	59 mg Trolox/g	1360:1373	59 mg Trolox/g	1360:1373	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	4	38	theme	Pa	1005:1006	arg1	modulus					988:994	a viscoelastic modulus	973:994	a viscoelastic modulus of 741.4 Pa	973:1006	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	4	38	theme	Pa	1005:1006	arg1	properties					961:970	good mechanical properties	945:970	good mechanical properties	945:970	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	1	39	theme	water	153:157	arg1	extraction					159:168	Ultrasound-assisted water extraction	133:168	Ultrasound-assisted water extraction	133:168	Ultrasound-assisted water extraction was optimized to recover gelling biopolymers and antioxidant compounds from Mastocarpus stellatus.
34069393	4	40	theme	viscoelastic	975:986	arg1	modulus					988:994	a viscoelastic modulus	973:994	a viscoelastic modulus of 741.4 Pa	973:1006	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	4	40	theme	viscoelastic	975:986	arg1	properties					961:970	good mechanical properties	945:970	good mechanical properties	945:970	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	4	41	theme	46	929:930	arg1	%					931:931	%	931:931	%	931:931	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	2	42	theme	sulfate	436:442	arg1	content					444:450	sulfate content	436:450	sulfate content	436:450	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	5	43	theme	selected	1132:1139	arg1	HeLa					1185:1188	HeLa 229	1185:1192	HeLa 229	1185:1192	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	43	theme	selected	1132:1139	arg1	A-549					1170:1174	A-549	1170:1174	A-549	1170:1174	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	43	theme	selected	1132:1139	arg1	A-2780					1177:1182	A-2780	1177:1182	A-2780	1177:1182	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	43	theme	selected	1132:1139	arg1	HT-29					1199:1203	HT-29	1199:1203	HT-29	1199:1203	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	43	theme	selected	1132:1139	arg1	lines					1163:1167	selected human cancer cellular lines	1132:1167	selected human cancer cellular lines	1132:1167	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	0	44	theme	Mastocarpus	40:50	arg1	Carrageenan					62:72	Mastocarpus stellatus Carrageenan	40:72	Mastocarpus stellatus Carrageenan	40:72	Ultrasound-Assisted Water Extraction of Mastocarpus stellatus Carrageenan with Adequate Mechanical and Antiproliferative Properties.
34069393	6	45	theme	gallic	1296:1301	arg1	acid					1303:1306	11.3 mg gallic acid	1288:1306	11.3 mg gallic acid eq/g	1288:1311	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	5	46	theme	human	1141:1145	arg1	HeLa					1185:1188	HeLa 229	1185:1192	HeLa 229	1185:1192	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	46	theme	human	1141:1145	arg1	A-549					1170:1174	A-549	1170:1174	A-549	1170:1174	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	46	theme	human	1141:1145	arg1	A-2780					1177:1182	A-2780	1177:1182	A-2780	1177:1182	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	46	theme	human	1141:1145	arg1	HT-29					1199:1203	HT-29	1199:1203	HT-29	1199:1203	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	46	theme	human	1141:1145	arg1	lines					1163:1167	selected human cancer cellular lines	1132:1167	selected human cancer cellular lines	1132:1167	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	6	47	theme	mg	1274:1275	arg1	eq/g					1308:1311	11.3 mg gallic acid eq/g	1288:1311	11.3 mg gallic acid eq/g	1288:1311	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	6	47	theme	mg	1274:1275	arg1	protein/g					1277:1285	20.4 mg protein/g	1269:1285	20.4 mg protein/g	1269:1285	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	0	48	theme	Adequate	79:86	arg1	Properties					121:130	Adequate Mechanical and Antiproliferative Properties	79:130	Adequate Mechanical and Antiproliferative Properties	79:130	Ultrasound-Assisted Water Extraction of Mastocarpus stellatus Carrageenan with Adequate Mechanical and Antiproliferative Properties.
34069393	2	49	theme	experiments	278:288	arg1	experiments					278:288	experiments	278:288	experiments following a Box-Behnken design	278:319	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	49	theme	experiments	278:288	arg1	set					271:273	A set	269:273	A set of experiments following a Box-Behnken design	269:319	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	0	50	with	Extraction	26:35	arg1	Properties					121:130	Adequate Mechanical and Antiproliferative Properties	79:130	Adequate Mechanical and Antiproliferative Properties	79:130	Ultrasound-Assisted Water Extraction of Mastocarpus stellatus Carrageenan with Adequate Mechanical and Antiproliferative Properties.
34069393	0	51	theme	Carrageenan	62:72	arg1	Extraction					26:35	Ultrasound-Assisted Water Extraction	0:35	Ultrasound-Assisted Water Extraction of Mastocarpus stellatus Carrageenan with Adequate Mechanical and Antiproliferative Properties	0:130	Ultrasound-Assisted Water Extraction of Mastocarpus stellatus Carrageenan with Adequate Mechanical and Antiproliferative Properties.
34069393	3	52	theme	liquid	779:784	arg1	ratio					786:790	solid liquid ratio	773:790	solid liquid ratio of ~2 g/100 g	773:804	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	4	53	theme	carrageenan	871:881	arg1	yield					883:887	40.3% carrageenan yield	865:887	40.3% carrageenan yield	865:887	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	0	54	dep	Mastocarpus	40:50	arg1	stellatus					52:60	stellatus	52:60	stellatus	52:60	Ultrasound-Assisted Water Extraction of Mastocarpus stellatus Carrageenan with Adequate Mechanical and Antiproliferative Properties.
34069393	2	55	theme	ratio	390:394	arg1	influence					347:355	the influence	343:355	the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts	343:663	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	5	56	theme	cellular	1154:1161	arg1	HeLa					1185:1188	HeLa 229	1185:1192	HeLa 229	1185:1192	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	56	theme	cellular	1154:1161	arg1	A-549					1170:1174	A-549	1170:1174	A-549	1170:1174	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	56	theme	cellular	1154:1161	arg1	A-2780					1177:1182	A-2780	1177:1182	A-2780	1177:1182	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	56	theme	cellular	1154:1161	arg1	HT-29					1199:1203	HT-29	1199:1203	HT-29	1199:1203	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	5	56	theme	cellular	1154:1161	arg1	lines					1163:1167	selected human cancer cellular lines	1132:1167	selected human cancer cellular lines	1132:1167	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	2	57	theme	liquid	383:388	arg1	ratio					390:394	solid liquid ratio	377:394	solid liquid ratio	377:394	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	1	58	theme	Ultrasound-assisted	133:151	arg1	extraction					159:168	Ultrasound-assisted water extraction	133:168	Ultrasound-assisted water extraction	133:168	Ultrasound-assisted water extraction was optimized to recover gelling biopolymers and antioxidant compounds from Mastocarpus stellatus.
34069393	2	59	theme	phenolic	598:605	arg1	content					607:613	phenolic content	598:613	phenolic content	598:613	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	3	60	dep	predicted	708:716	arg1	a					718:718	a	718:718	a	718:718	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	3	60	dep	predicted	708:716	arg1	compromise					720:729	compromise	720:729	predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%	708:838	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	1	61	theme	gelling	195:201	arg1	biopolymers					203:213	gelling biopolymers	195:213	gelling biopolymers	195:213	Ultrasound-assisted water extraction was optimized to recover gelling biopolymers and antioxidant compounds from Mastocarpus stellatus.
34069393	2	62	from	influence	347:355	arg1	properties					476:485	thermo-rheological properties	457:485	thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction	457:555	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	62	from	influence	347:355	arg1	viscoelasticity					488:502	viscoelasticity	488:502	viscoelasticity	488:502	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	62	from	influence	347:355	arg1	content					444:450	sulfate content	436:450	sulfate content	436:450	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	62	from	influence	347:355	arg1	yield					429:433	the yield	425:433	the yield	425:433	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	62	from	influence	347:355	arg1	composition					573:583	the composition	569:583	the composition (protein and phenolic content)	569:614	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	62	from	influence	347:355	arg1	temperature					516:526	gelling temperature	508:526	gelling temperature	508:526	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	62	from	influence	347:355	arg1	capacity					632:639	antiradical capacity	620:639	antiradical capacity of the soluble extracts	620:663	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	0	63	theme	Mechanical	88:97	arg1	Properties					121:130	Adequate Mechanical and Antiproliferative Properties	79:130	Adequate Mechanical and Antiproliferative Properties	79:130	Ultrasound-Assisted Water Extraction of Mastocarpus stellatus Carrageenan with Adequate Mechanical and Antiproliferative Properties.
34069393	6	64	theme	antiradical	1322:1332	arg1	equivalent					1346:1355	equivalent	1346:1355	equivalent	1346:1355	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	6	64	theme	antiradical	1322:1332	arg1	potency					1334:1340	the antiradical potency	1318:1340	the antiradical potency	1318:1340	The dried soluble extract contained 20.4 mg protein/g, 11.3 mg gallic acid eq/g, and the antiradical potency was equivalent to 59 mg Trolox/g.
34069393	4	65	theme	°C	1054:1055	arg1	temperatures					1033:1044	the lowest gelling temperatures	1014:1044	the lowest gelling temperatures of 39.4 °C	1014:1055	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	4	66	theme	good	945:948	arg1	modulus					988:994	a viscoelastic modulus	973:994	a viscoelastic modulus of 741.4 Pa	973:1006	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	4	66	theme	good	945:948	arg1	properties					961:970	good mechanical properties	945:970	good mechanical properties	945:970	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	2	67	theme	fraction	548:555	arg1	properties					476:485	thermo-rheological properties	457:485	thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction	457:555	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	67	theme	fraction	548:555	arg1	viscoelasticity					488:502	viscoelasticity	488:502	viscoelasticity	488:502	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	67	theme	fraction	548:555	arg1	content					444:450	sulfate content	436:450	sulfate content	436:450	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	67	theme	fraction	548:555	arg1	capacity					632:639	antiradical capacity	620:639	antiradical capacity of the soluble extracts	620:663	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	67	theme	fraction	548:555	arg1	composition					573:583	the composition	569:583	the composition (protein and phenolic content)	569:614	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	67	theme	fraction	548:555	arg1	temperature					516:526	gelling temperature	508:526	gelling temperature	508:526	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	67	theme	fraction	548:555	arg1	yield					429:433	the yield	425:433	the yield	425:433	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	5	68	theme	promising	1090:1098	arg1	properties					1118:1127	promising antiproliferative properties	1090:1127	promising antiproliferative properties	1090:1127	The carrageenans also exhibited promising antiproliferative properties on selected human cancer cellular lines, A-549, A-2780, HeLa 229, and HT-29 with EC50 under 51.9 μg/mL.
34069393	2	69	theme	Box-Behnken	302:312	arg1	design					314:319	a Box-Behnken design	300:319	a Box-Behnken design	300:319	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	2	70	theme	amplitude	412:420	arg1	influence					347:355	the influence	343:355	the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts	343:663	A set of experiments following a Box-Behnken design was proposed to study the influence of extraction time, solid liquid ratio, and ultrasound amplitude on the yield, sulfate content, and thermo-rheological properties (viscoelasticity and gelling temperature) of the carrageenan fraction, as well as the composition (protein and phenolic content) and antiradical capacity of the soluble extracts.
34069393	4	71	theme	lowest	1018:1023	arg1	temperatures					1033:1044	the lowest gelling temperatures	1014:1044	the lowest gelling temperatures of 39.4 °C	1014:1055	Under these conditions, 40.3% carrageenan yield was attained and this product presented 46% sulfate and good mechanical properties, a viscoelastic modulus of 741.4 Pa, with the lowest gelling temperatures of 39.4 °C.
34069393	3	72	theme	g	804:804	arg1	amplitude					822:830	ultrasound amplitude	811:830	ultrasound amplitude of ~79%	811:838	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	3	72	theme	g	804:804	arg1	conditions					750:759	optimum extraction conditions	731:759	optimum extraction conditions at ~35 min	731:770	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34069393	3	72	theme	g	804:804	arg1	ratio					786:790	solid liquid ratio	773:790	solid liquid ratio of ~2 g/100 g	773:804	Operating at 80 °C and 80 kHz, the models predicted a compromise optimum extraction conditions at ~35 min, solid liquid ratio of ~2 g/100 g, and ultrasound amplitude of ~79%.
34826906	3	0	theme	adsorption	514:523	arg1	capacity					525:532	a maximum adsorption capacity	504:532	a maximum adsorption capacity (1393.338 mg g-1)	504:550	The CSP/CP exhibits a maximum adsorption capacity (1393.338 mg g-1) and selectivity (Su = 80.53%) for uranium, which is higher than many reported adsorbents.
34826906	3	0	theme	adsorption	514:523	arg1	1393.338 mg g-1					535:549	1393.338 mg g-1	535:549	1393.338 mg g-1	535:549	The CSP/CP exhibits a maximum adsorption capacity (1393.338 mg g-1) and selectivity (Su = 80.53%) for uranium, which is higher than many reported adsorbents.
34826906	4	1	with	structure	797:805	arg1	sites					819:823	active sites	812:823	active sites for high-performance uranium adsorption	812:863	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	1	2	from	wastewater	169:178	arg1	metallurgy					202:211	metallurgy	202:211	metallurgy	202:211	In order to remove and recover uranium from acidic uranium-bearing wastewater in uranium mining and metallurgy.
34826906	1	2	from	wastewater	169:178	arg1	mining					191:196	uranium mining	183:196	uranium mining	183:196	In order to remove and recover uranium from acidic uranium-bearing wastewater in uranium mining and metallurgy.
34826906	2	3	theme	adsorption	374:383	arg1	capacity					385:392	a high uranium adsorption capacity	359:392	a high uranium adsorption capacity	359:392	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	3	4	theme	reported	621:628	arg1	adsorbents					630:639	many reported adsorbents	616:639	many reported adsorbents	616:639	The CSP/CP exhibits a maximum adsorption capacity (1393.338 mg g-1) and selectivity (Su = 80.53%) for uranium, which is higher than many reported adsorbents.
34826906	6	5	theme	selectivity	1153:1163	arg1	preparation					1133:1143	the preparation	1129:1143	the preparation of high selectivity composite adsorbent by chitosan	1129:1195	It provides a new scientific basis for the preparation of high selectivity composite adsorbent by chitosan.
34826906	6	6	theme	adsorbent	1175:1183	arg1	selectivity					1153:1163	high selectivity	1148:1163	high selectivity composite adsorbent by chitosan	1148:1195	It provides a new scientific basis for the preparation of high selectivity composite adsorbent by chitosan.
34826906	5	7	from	318 K	1038:1042	arg1	Na2CO3					1018:1023	0.1 M Na2CO3	1012:1023	0.1 M Na2CO3	1012:1023	Furthermore, by desorption with 0.1 M Na2CO3 + 2% H2O2 at 318 K, CSP/CP can be recycled more than five times.
34826906	6	8	theme	scientific	1108:1117	arg1	basis					1119:1123	a new scientific basis	1102:1123	a new scientific basis for the preparation of high selectivity composite adsorbent by chitosan	1102:1195	It provides a new scientific basis for the preparation of high selectivity composite adsorbent by chitosan.
34826906	5	9	dep	Na2CO3	1018:1023	arg1	desorption					996:1005	desorption	996:1005	desorption	996:1005	Furthermore, by desorption with 0.1 M Na2CO3 + 2% H2O2 at 318 K, CSP/CP can be recycled more than five times.
34826906	4	10	theme	hydroxyl	705:712	arg1	groups					745:750	hydroxyl, amino, phosphate and carboxyl groups	705:750	groups	745:750	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	4	11	theme	uranium	846:852	arg1	adsorption					854:863	high-performance uranium adsorption	829:863	high-performance uranium adsorption	829:863	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	4	12	from	groups	745:750	arg1	rich					697:700	rich	697:700	rich	697:700	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	4	12	from	groups	745:750	arg1	surface					676:682	the surface	672:682	the surface of CSP/CP	672:692	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	6	13	theme	new	1104:1106	arg1	basis					1119:1123	a new scientific basis	1102:1123	a new scientific basis for the preparation of high selectivity composite adsorbent by chitosan	1102:1195	It provides a new scientific basis for the preparation of high selectivity composite adsorbent by chitosan.
34826906	1	14	theme	uranium	183:189	arg1	mining					191:196	uranium mining	183:196	uranium mining	183:196	In order to remove and recover uranium from acidic uranium-bearing wastewater in uranium mining and metallurgy.
34826906	2	15	theme	coexisting	467:476	arg1	ions					478:481	eight coexisting ions	461:481	eight coexisting ions	461:481	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	4	16	theme	high-performance	829:844	arg1	adsorption					854:863	high-performance uranium adsorption	829:863	high-performance uranium adsorption	829:863	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	4	17	dep	bound	887:891	arg1	VI					868:869	VI	868:869	VI	868:869	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	4	18	with	exchanges	901:909	arg1	-OH					926:928	-OH	926:928	-OH	926:928	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	4	18	with	exchanges	901:909	arg1	-COOH					916:920	-COOH	916:920	-COOH	916:920	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	2	19	theme	5	405:405	arg1	selectivity					421:431	excellent selectivity	411:431	excellent selectivity in an aqueous solution with eight coexisting ions	411:481	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	2	19	theme	5	405:405	arg1	pH					399:400	a pH	397:400	a pH of 5	397:405	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	4	20	theme	phosphate	722:730	arg1	groups					745:750	hydroxyl, amino, phosphate and carboxyl groups	705:750	groups	745:750	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	5	21	theme	2	1027:1027	arg1	%					1028:1028	%	1028:1028	%	1028:1028	Furthermore, by desorption with 0.1 M Na2CO3 + 2% H2O2 at 318 K, CSP/CP can be recycled more than five times.
34826906	6	22	theme	high	1148:1151	arg1	selectivity					1153:1163	high selectivity	1148:1163	high selectivity composite adsorbent by chitosan	1148:1195	It provides a new scientific basis for the preparation of high selectivity composite adsorbent by chitosan.
34826906	4	23	theme	carboxyl	736:743	arg1	groups					745:750	hydroxyl, amino, phosphate and carboxyl groups	705:750	groups	745:750	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	4	24	theme	active	812:817	arg1	sites					819:823	active sites	812:823	active sites for high-performance uranium adsorption	812:863	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	2	25	theme	aqueous	439:445	arg1	solution					447:454	an aqueous solution	436:454	an aqueous solution with eight coexisting ions	436:481	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	4	26	theme	ion	897:899	arg1	exchanges					901:909	ion exchanges	897:909	ion exchanges with -COOH and -OH	897:928	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	5	27	theme	%	1028:1028	arg1	H2O2					1030:1033	2% H2O2	1027:1033	2% H2O2	1027:1033	Furthermore, by desorption with 0.1 M Na2CO3 + 2% H2O2 at 318 K, CSP/CP can be recycled more than five times.
34826906	4	28	theme	CSP/CP	687:692	arg1	rich					697:700	rich	697:700	rich	697:700	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	4	28	theme	CSP/CP	687:692	arg1	surface					676:682	the surface	672:682	the surface of CSP/CP	672:692	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	0	29	theme	pyrenoidosa	44:54	arg1	ligand					94:99	chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	25:99	chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	25:99	Adsorption of uranium by chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand.
34826906	3	30	theme	maximum	506:512	arg1	capacity					525:532	a maximum adsorption capacity	504:532	a maximum adsorption capacity (1393.338 mg g-1)	504:550	The CSP/CP exhibits a maximum adsorption capacity (1393.338 mg g-1) and selectivity (Su = 80.53%) for uranium, which is higher than many reported adsorbents.
34826906	3	30	theme	maximum	506:512	arg1	1393.338 mg g-1					535:549	1393.338 mg g-1	535:549	1393.338 mg g-1	535:549	The CSP/CP exhibits a maximum adsorption capacity (1393.338 mg g-1) and selectivity (Su = 80.53%) for uranium, which is higher than many reported adsorbents.
34826906	2	31	theme	composite	261:269	arg1	CSP/CP					307:312	CSP/CP	307:312	CSP/CP	307:312	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	2	31	theme	composite	261:269	arg1	ligand					299:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	222:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP)	222:313	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	0	32	theme	chitosan/Chlorella	25:42	arg1	ligand					94:99	chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	25:99	chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	25:99	Adsorption of uranium by chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand.
34826906	4	33	dep	VI	868:869	arg1	U					866:866	U	866:866	U	866:866	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	2	34	theme	pyrenoidosa	249:259	arg1	CSP/CP					307:312	CSP/CP	307:312	CSP/CP	307:312	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	2	34	theme	pyrenoidosa	249:259	arg1	ligand					299:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	222:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP)	222:313	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	2	35	with	solution	447:454	arg1	ions					478:481	eight coexisting ions	461:481	eight coexisting ions	461:481	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	2	36	theme	excellent	411:419	arg1	selectivity					421:431	excellent selectivity	411:431	excellent selectivity in an aqueous solution with eight coexisting ions	411:481	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	0	37	theme	adsorbent	66:74	arg1	ligand					94:99	chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	25:99	chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	25:99	Adsorption of uranium by chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand.
34826906	4	38	theme	surface	942:948	arg1	complexation					950:961	surface complexation	942:961	surface complexation with NH2 and PO	942:977	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	2	39	theme	chitosan/Chlorella	230:247	arg1	CSP/CP					307:312	CSP/CP	307:312	CSP/CP	307:312	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	2	39	theme	chitosan/Chlorella	230:247	arg1	ligand					299:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	222:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP)	222:313	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	2	40	from	pH	399:400	arg1	solution					447:454	an aqueous solution	436:454	an aqueous solution with eight coexisting ions	436:481	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	2	41	theme	uranium	366:372	arg1	capacity					385:392	a high uranium adsorption capacity	359:392	a high uranium adsorption capacity	359:392	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	0	42	theme	composite	56:64	arg1	ligand					94:99	chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	25:99	chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	25:99	Adsorption of uranium by chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand.
34826906	2	43	theme	novel	224:228	arg1	CSP/CP					307:312	CSP/CP	307:312	CSP/CP	307:312	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	2	43	theme	novel	224:228	arg1	ligand					299:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	222:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP)	222:313	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	4	44	with	complexation	950:961	arg1	PO					976:977	PO	976:977	PO	976:977	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	4	44	with	complexation	950:961	arg1	NH2					968:970	NH2	968:970	NH2	968:970	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	2	45	theme	high	361:364	arg1	capacity					385:392	a high uranium adsorption capacity	359:392	a high uranium adsorption capacity	359:392	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	4	46	theme	three-dimensional	779:795	arg1	structure					797:805	an excellent three-dimensional structure	766:805	an excellent three-dimensional structure with active sites for high-performance uranium adsorption	766:863	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	2	47	theme	adsorbent	271:279	arg1	CSP/CP					307:312	CSP/CP	307:312	CSP/CP	307:312	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	2	47	theme	adsorbent	271:279	arg1	ligand					299:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	222:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP)	222:313	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	4	48	theme	excellent	769:777	arg1	structure					797:805	an excellent three-dimensional structure	766:805	an excellent three-dimensional structure with active sites for high-performance uranium adsorption	766:863	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	3	49	theme	many	616:619	arg1	adsorbents					630:639	many reported adsorbents	616:639	many reported adsorbents	616:639	The CSP/CP exhibits a maximum adsorption capacity (1393.338 mg g-1) and selectivity (Su = 80.53%) for uranium, which is higher than many reported adsorbents.
34826906	4	50	theme	amino	715:719	arg1	groups					745:750	hydroxyl, amino, phosphate and carboxyl groups	705:750	groups	745:750	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	2	51	theme	phosphate	289:297	arg1	CSP/CP					307:312	CSP/CP	307:312	CSP/CP	307:312	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	2	51	theme	phosphate	289:297	arg1	ligand					299:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	222:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP)	222:313	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	2	52	from	selectivity	421:431	arg1	solution					447:454	an aqueous solution	436:454	an aqueous solution with eight coexisting ions	436:481	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	0	53	theme	phosphate	84:92	arg1	ligand					94:99	chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	25:99	chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	25:99	Adsorption of uranium by chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand.
34826906	4	54	theme	Mechanism	642:650	arg1	analysis					652:659	Mechanism analysis	642:659	Mechanism analysis	642:659	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34826906	2	55	theme	bearing	281:287	arg1	CSP/CP					307:312	CSP/CP	307:312	CSP/CP	307:312	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	2	55	theme	bearing	281:287	arg1	ligand					299:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	222:304	a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP)	222:313	Herein, a novel chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand (CSP/CP) was designed and synthesized, demonstrating a high uranium adsorption capacity at a pH of 5 and excellent selectivity in an aqueous solution with eight coexisting ions.
34826906	1	56	theme	acidic	146:151	arg1	wastewater					169:178	acidic uranium-bearing wastewater	146:178	acidic uranium-bearing wastewater in uranium mining and metallurgy	146:211	In order to remove and recover uranium from acidic uranium-bearing wastewater in uranium mining and metallurgy.
34826906	0	57	theme	bearing	76:82	arg1	ligand					94:99	chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	25:99	chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand	25:99	Adsorption of uranium by chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand.
34826906	0	58	theme	uranium	14:20	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of uranium by chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand.	0:100	Adsorption of uranium by chitosan/Chlorella pyrenoidosa composite adsorbent bearing phosphate ligand.
34826906	1	59	theme	uranium-bearing	153:167	arg1	wastewater					169:178	acidic uranium-bearing wastewater	146:178	acidic uranium-bearing wastewater in uranium mining and metallurgy	146:211	In order to remove and recover uranium from acidic uranium-bearing wastewater in uranium mining and metallurgy.
34826906	4	60	from	rich	697:700	arg1	groups					745:750	hydroxyl, amino, phosphate and carboxyl groups	705:750	groups	745:750	Mechanism analysis shows that the surface of CSP/CP is rich in hydroxyl, amino, phosphate and carboxyl groups, resulting in an excellent three-dimensional structure with active sites for high-performance uranium adsorption; U(VI) is selectively bound via ion exchanges with -COOH and -OH and through surface complexation with NH2 and PO.
34119175	0	0	theme	flour	93:97	arg1	composites					99:108	coated wood flour composites	81:108	coated wood flour composites	81:108	Multi-layer oil-resistant food serving containers made using cellulose nanofiber coated wood flour composites.
34119175	5	1	theme	commercial	824:833	arg1	containers					840:849	commercial food containers	824:849	commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability	824:959	All composites had higher flexural and tensile properties compared with commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability.
34119175	5	2	theme	binder	909:914	arg1	content					916:922	binder content	909:922	binder content	909:922	All composites had higher flexural and tensile properties compared with commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability.
34119175	4	3	theme	surface	580:586	arg1	energy					593:598	The surface free energy	576:598	The surface free energy	576:598	The surface free energy and water contact angle showed that the composites with LCNF coating were more hydrophobic than the ones coated with CNF made from bleached pulp fiber.
34119175	0	4	theme	wood	88:91	arg1	composites					99:108	coated wood flour composites	81:108	coated wood flour composites	81:108	Multi-layer oil-resistant food serving containers made using cellulose nanofiber coated wood flour composites.
34119175	1	5	theme	serving	175:181	arg1	containers					183:192	grease-resistant food serving containers	153:192	grease-resistant food serving containers	153:192	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	1	6	theme	lignin-containing	256:272	arg1	LCNF					297:300	LCNF	297:300	LCNF	297:300	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	1	6	theme	lignin-containing	256:272	arg1	nanofibrils					284:294	lignin-containing cellulose nanofibrils	256:294	lignin-containing cellulose nanofibrils (LCNF)	256:301	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	3	7	theme	"	534:534	arg1	#					549:549	the "kit" test passing #12	526:551	the "kit" test passing #12	526:551	All composites showed excellent oil/grease resistivity according to the "kit" test passing #12, the highest possible.
34119175	1	8	theme	cellulose	274:282	arg1	LCNF					297:300	LCNF	297:300	LCNF	297:300	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	1	8	theme	cellulose	274:282	arg1	nanofibrils					284:294	lignin-containing cellulose nanofibrils	256:294	lignin-containing cellulose nanofibrils (LCNF)	256:301	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	6	9	theme	commercial	1188:1197	arg1	food					1199:1202	oil-resistant commercial food	1174:1202	oil-resistant commercial food serving containers	1174:1221	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	6	10	theme	poly-fluoroalkyl	1118:1133	arg1	substances					1135:1144	poly-fluoroalkyl substances	1118:1144	poly-fluoroalkyl substances (PFAs)	1118:1151	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	6	10	theme	poly-fluoroalkyl	1118:1133	arg1	PFAs					1147:1150	PFAs	1147:1150	PFAs	1147:1150	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	4	11	theme	free	588:591	arg1	energy					593:598	The surface free energy	576:598	The surface free energy	576:598	The surface free energy and water contact angle showed that the composites with LCNF coating were more hydrophobic than the ones coated with CNF made from bleached pulp fiber.
34119175	5	12	dep	flexural	778:785	arg1	higher					771:776	higher	771:776	higher	771:776	All composites had higher flexural and tensile properties compared with commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability.
34119175	5	13	theme	food	835:838	arg1	containers					840:849	commercial food containers	824:849	commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability	824:959	All composites had higher flexural and tensile properties compared with commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability.
34119175	3	14	theme	passing	541:547	arg1	#					549:549	the "kit" test passing #12	526:551	the "kit" test passing #12	526:551	All composites showed excellent oil/grease resistivity according to the "kit" test passing #12, the highest possible.
34119175	4	15	theme	LCNF	656:659	arg1	coating					661:667	LCNF coating	656:667	LCNF coating	656:667	The surface free energy and water contact angle showed that the composites with LCNF coating were more hydrophobic than the ones coated with CNF made from bleached pulp fiber.
34119175	3	16	theme	excellent	480:488	arg1	resistivity					501:511	excellent oil/grease resistivity	480:511	excellent oil/grease resistivity	480:511	All composites showed excellent oil/grease resistivity according to the "kit" test passing #12, the highest possible.
34119175	5	17	theme	tensile	791:797	arg1	properties					799:808	higher flexural and tensile properties	771:808	higher flexural and tensile properties	771:808	All composites had higher flexural and tensile properties compared with commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability.
34119175	5	18	theme	mechanical	861:870	arg1	properties					872:881	the mechanical properties	857:881	the mechanical properties	857:881	All composites had higher flexural and tensile properties compared with commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability.
34119175	0	19	theme	oil-resistant	12:24	arg1	containers					39:48	Multi-layer oil-resistant food serving containers	0:48	Multi-layer oil-resistant food serving containers made using cellulose	0:69	Multi-layer oil-resistant food serving containers made using cellulose nanofiber coated wood flour composites.
34119175	3	20	theme	test	536:539	arg1	#					549:549	the "kit" test passing #12	526:551	the "kit" test passing #12	526:551	All composites showed excellent oil/grease resistivity according to the "kit" test passing #12, the highest possible.
34119175	6	21	contain	possess	1006:1012	arg1	alternative					1158:1168	a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative	1083:1168	a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers	1083:1221	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	6	21	contain	possess	1006:1012	arg2	properties					1047:1056	excellent mechanical and barrier properties	1014:1056	properties	1047:1056	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	6	21	contain	possess	1006:1012	arg2	mechanical					1024:1033	mechanical	1024:1033	mechanical	1024:1033	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	6	21	contain	possess	1006:1012	arg1	composites					995:1004	the cellulose nanofiber composites	971:1004	the cellulose nanofiber composites	971:1004	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	2	22	theme	nanofiber	387:395	arg1	composites					397:406	The multi-layer wet-on-wet cellulose nanofiber composites	350:406	The multi-layer wet-on-wet cellulose nanofiber composites	350:406	The multi-layer wet-on-wet cellulose nanofiber composites were developed using a vacuum filtration process.
34119175	0	23	theme	Multi-layer	0:10	arg1	containers					39:48	Multi-layer oil-resistant food serving containers	0:48	Multi-layer oil-resistant food serving containers made using cellulose	0:69	Multi-layer oil-resistant food serving containers made using cellulose nanofiber coated wood flour composites.
34119175	1	24	dep	serving	175:181	arg1	food					170:173	food	170:173	food	170:173	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	2	25	theme	cellulose	377:385	arg1	composites					397:406	The multi-layer wet-on-wet cellulose nanofiber composites	350:406	The multi-layer wet-on-wet cellulose nanofiber composites	350:406	The multi-layer wet-on-wet cellulose nanofiber composites were developed using a vacuum filtration process.
34119175	0	26	theme	serving	31:37	arg1	containers					39:48	Multi-layer oil-resistant food serving containers	0:48	Multi-layer oil-resistant food serving containers made using cellulose	0:69	Multi-layer oil-resistant food serving containers made using cellulose nanofiber coated wood flour composites.
34119175	6	27	theme	nanofiber	985:993	arg1	alternative					1158:1168	a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative	1083:1168	a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers	1083:1221	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	6	27	theme	nanofiber	985:993	arg1	composites					995:1004	the cellulose nanofiber composites	971:1004	the cellulose nanofiber composites	971:1004	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	5	28	theme	thermal	943:949	arg1	stability					951:959	acceptable thermal stability	932:959	acceptable thermal stability	932:959	All composites had higher flexural and tensile properties compared with commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability.
34119175	4	29	theme	pulp	740:743	arg1	fiber					745:749	bleached pulp fiber	731:749	bleached pulp fiber	731:749	The surface free energy and water contact angle showed that the composites with LCNF coating were more hydrophobic than the ones coated with CNF made from bleached pulp fiber.
34119175	2	30	theme	vacuum	431:436	arg1	process					449:455	a vacuum filtration process	429:455	a vacuum filtration process	429:455	The multi-layer wet-on-wet cellulose nanofiber composites were developed using a vacuum filtration process.
34119175	2	31	theme	filtration	438:447	arg1	process					449:455	a vacuum filtration process	429:455	a vacuum filtration process	429:455	The multi-layer wet-on-wet cellulose nanofiber composites were developed using a vacuum filtration process.
34119175	6	32	theme	cellulose	975:983	arg1	alternative					1158:1168	a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative	1083:1168	a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers	1083:1221	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	6	32	theme	cellulose	975:983	arg1	composites					995:1004	the cellulose nanofiber composites	971:1004	the cellulose nanofiber composites	971:1004	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	4	33	theme	bleached	731:738	arg1	fiber					745:749	bleached pulp fiber	731:749	bleached pulp fiber	731:749	The surface free energy and water contact angle showed that the composites with LCNF coating were more hydrophobic than the ones coated with CNF made from bleached pulp fiber.
34119175	3	34	theme	oil/grease	490:499	arg1	resistivity					501:511	excellent oil/grease resistivity	480:511	excellent oil/grease resistivity	480:511	All composites showed excellent oil/grease resistivity according to the "kit" test passing #12, the highest possible.
34119175	1	35	theme	coating	303:309	arg1	layers					311:316	coating layers	303:316	coating layers	303:316	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	6	36	dep	wood-flour-based	1085:1100	arg1	pulp-free					1103:1111	pulp-free	1103:1111	pulp-free	1103:1111	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	1	37	with	flour	214:218	arg1	nanofibrils					235:245	cellulose nanofibrils	225:245	cellulose nanofibrils	225:245	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	6	38	theme	barrier	1039:1045	arg1	properties					1047:1056	excellent mechanical and barrier properties	1014:1056	properties	1047:1056	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	1	39	theme	cellulose	225:233	arg1	nanofibrils					235:245	cellulose nanofibrils	225:245	cellulose nanofibrils	225:245	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	5	40	theme	flexural	778:785	arg1	properties					799:808	higher flexural and tensile properties	771:808	higher flexural and tensile properties	771:808	All composites had higher flexural and tensile properties compared with commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability.
34119175	1	41	with	nanofibrils	284:294	arg1	nanofibrils					235:245	cellulose nanofibrils	225:245	cellulose nanofibrils	225:245	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	4	42	with	composites	640:649	arg1	coating					661:667	LCNF coating	656:667	LCNF coating	656:667	The surface free energy and water contact angle showed that the composites with LCNF coating were more hydrophobic than the ones coated with CNF made from bleached pulp fiber.
34119175	5	43	contain	had	928:930	arg2	stability					951:959	acceptable thermal stability	932:959	acceptable thermal stability	932:959	All composites had higher flexural and tensile properties compared with commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability.
34119175	5	43	contain	had	928:930	arg1	properties					872:881	the mechanical properties	857:881	the mechanical properties	857:881	All composites had higher flexural and tensile properties compared with commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability.
34119175	6	44	theme	-free	1152:1156	arg1	composites					995:1004	the cellulose nanofiber composites	971:1004	the cellulose nanofiber composites	971:1004	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	6	44	theme	-free	1152:1156	arg1	alternative					1158:1168	a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative	1083:1168	a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers	1083:1221	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	0	45	dep	serving	31:37	arg1	food					26:29	food	26:29	food	26:29	Multi-layer oil-resistant food serving containers made using cellulose nanofiber coated wood flour composites.
34119175	5	46	theme	acceptable	932:941	arg1	stability					951:959	acceptable thermal stability	932:959	acceptable thermal stability	932:959	All composites had higher flexural and tensile properties compared with commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability.
34119175	6	47	theme	oil-resistant	1174:1186	arg1	food					1199:1202	oil-resistant commercial food	1174:1202	oil-resistant commercial food serving containers	1174:1221	Overall, the cellulose nanofiber composites possess excellent mechanical and barrier properties and can be considered as a wood-flour-based (pulp-free) and poly-fluoroalkyl substances (PFAs)-free alternative for oil-resistant commercial food serving containers.
34119175	4	48	theme	water	604:608	arg1	angle					618:622	water contact angle	604:622	water contact angle	604:622	The surface free energy and water contact angle showed that the composites with LCNF coating were more hydrophobic than the ones coated with CNF made from bleached pulp fiber.
34119175	2	49	theme	multi-layer	354:364	arg1	composites					397:406	The multi-layer wet-on-wet cellulose nanofiber composites	350:406	The multi-layer wet-on-wet cellulose nanofiber composites	350:406	The multi-layer wet-on-wet cellulose nanofiber composites were developed using a vacuum filtration process.
34119175	0	50	theme	coated	81:86	arg1	composites					99:108	coated wood flour composites	81:108	coated wood flour composites	81:108	Multi-layer oil-resistant food serving containers made using cellulose nanofiber coated wood flour composites.
34119175	5	51	contain	had	767:769	arg2	properties					799:808	higher flexural and tensile properties	771:808	higher flexural and tensile properties	771:808	All composites had higher flexural and tensile properties compared with commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability.
34119175	5	51	contain	had	767:769	arg1	composites					756:765	All composites	752:765	All composites	752:765	All composites had higher flexural and tensile properties compared with commercial food containers where the mechanical properties increased with increasing binder content and had acceptable thermal stability.
34119175	1	52	theme	wood	209:212	arg1	CNF					248:250	CNF	248:250	CNF	248:250	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	1	52	theme	wood	209:212	arg1	flour					214:218	wood flour	209:218	wood flour with cellulose nanofibrils (CNF)	209:251	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	2	53	theme	wet-on-wet	366:375	arg1	composites					397:406	The multi-layer wet-on-wet cellulose nanofiber composites	350:406	The multi-layer wet-on-wet cellulose nanofiber composites	350:406	The multi-layer wet-on-wet cellulose nanofiber composites were developed using a vacuum filtration process.
34119175	1	54	dep	flour	214:218	arg1	layers					311:316	coating layers	303:316	coating layers	303:316	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	1	55	theme	grease-resistant	153:168	arg1	containers					183:192	grease-resistant food serving containers	153:192	grease-resistant food serving containers	153:192	Cost-effective, eco-friendly, and oil and grease-resistant food serving containers were made from wood flour with cellulose nanofibrils (CNF) or lignin-containing cellulose nanofibrils (LCNF) coating layers on the surface and in the bulk.
34119175	4	56	theme	contact	610:616	arg1	angle					618:622	water contact angle	604:622	water contact angle	604:622	The surface free energy and water contact angle showed that the composites with LCNF coating were more hydrophobic than the ones coated with CNF made from bleached pulp fiber.
33049889	0	0	theme	Jughans	87:93	arg1	polyphenols					104:114	Jughans regia L. polyphenols	87:114	Jughans regia L. polyphenols	87:114	Development of the pH responsive chitosan-alginate based microgel for encapsulation of Jughans regia L. polyphenols under simulated gastrointestinal digestion in vitro.
33049889	1	1	from	shells	330:335	arg1	polyphenols					309:319	the polyphenols	305:319	the polyphenols from the shells of Juglans regia L. (JRP-Microgel)	305:370	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	3	2	contain	possessed	757:765	arg1	JRP-Microgel					744:755	JRP-Microgel	744:755	JRP-Microgel	744:755	JRP-Microgel possessed better physicochemical stabilities compared with unencapsulated JRP.
33049889	3	2	contain	possessed	757:765	arg2	stabilities					790:800	better physicochemical stabilities	767:800	better physicochemical stabilities	767:800	JRP-Microgel possessed better physicochemical stabilities compared with unencapsulated JRP.
33049889	1	3	theme	L	354:354	arg1	shells					330:335	the shells	326:335	the shells of Juglans regia L. (JRP-Microgel)	326:370	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	5	4	theme	gastrointestinal	1180:1195	arg1	digestion					1197:1205	gastrointestinal digestion	1180:1205	gastrointestinal digestion	1180:1205	Nevertheless, during different digestive phase, the phenolic composition of microgel was significantly different from the one of untreated JRP, suggesting that JRP-Microgel could prevent the degradation of JRP induced by gastrointestinal digestion.
33049889	2	5	theme	neat	707:710	arg1	edge					712:715	neat edge	707:715	neat edge	707:715	The results showed that JRP-Microgel belonged to semi-crystalline substances, and presented regular spherical or subspherical shape with neat edge and uniform particle size.
33049889	1	6	theme	present	173:179	arg1	research					181:188	The present research	169:188	The present research	169:188	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	2	7	theme	uniform	721:727	arg1	size					738:741	uniform particle size	721:741	uniform particle size	721:741	The results showed that JRP-Microgel belonged to semi-crystalline substances, and presented regular spherical or subspherical shape with neat edge and uniform particle size.
33049889	5	8	theme	untreated	1088:1096	arg1	JRP					1098:1100	untreated JRP	1088:1100	untreated JRP	1088:1100	Nevertheless, during different digestive phase, the phenolic composition of microgel was significantly different from the one of untreated JRP, suggesting that JRP-Microgel could prevent the degradation of JRP induced by gastrointestinal digestion.
33049889	6	9	theme	encapsulation	1300:1312	arg1	application					1276:1286	the application	1272:1286	the application of microgel encapsulation to improve the bioavailability of phenolic compounds in human body	1272:1379	In conclusion, above results provide the experimental basis for the application of microgel encapsulation to improve the bioavailability of phenolic compounds in human body.
33049889	2	10	theme	semi-crystalline	619:634	arg1	substances					636:645	semi-crystalline substances	619:645	semi-crystalline substances	619:645	The results showed that JRP-Microgel belonged to semi-crystalline substances, and presented regular spherical or subspherical shape with neat edge and uniform particle size.
33049889	1	11	theme	analyze	447:453	arg1	properties					409:418	the physicochemical properties	389:418	the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro	389:567	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	5	12	theme	JRP	1098:1100	arg1	one					1081:1083	the one	1077:1083	the one of untreated JRP	1077:1100	Nevertheless, during different digestive phase, the phenolic composition of microgel was significantly different from the one of untreated JRP, suggesting that JRP-Microgel could prevent the degradation of JRP induced by gastrointestinal digestion.
33049889	2	13	theme	subspherical	683:694	arg1	shape					696:700	regular spherical or subspherical shape	662:700	regular spherical or subspherical shape	662:700	The results showed that JRP-Microgel belonged to semi-crystalline substances, and presented regular spherical or subspherical shape with neat edge and uniform particle size.
33049889	5	14	theme	different	980:988	arg1	phase					1000:1004	different digestive phase	980:1004	different digestive phase	980:1004	Nevertheless, during different digestive phase, the phenolic composition of microgel was significantly different from the one of untreated JRP, suggesting that JRP-Microgel could prevent the degradation of JRP induced by gastrointestinal digestion.
33049889	0	15	theme	polyphenols	104:114	arg1	encapsulation					70:82	encapsulation	70:82	encapsulation of Jughans regia L. polyphenols	70:114	Development of the pH responsive chitosan-alginate based microgel for encapsulation of Jughans regia L. polyphenols under simulated gastrointestinal digestion in vitro.
33049889	3	16	theme	better	767:772	arg1	stabilities					790:800	better physicochemical stabilities	767:800	better physicochemical stabilities	767:800	JRP-Microgel possessed better physicochemical stabilities compared with unencapsulated JRP.
33049889	1	17	theme	release	459:465	arg1	variation					507:515	the release characteristic and phenolic composition variation	455:515	the release characteristic and phenolic composition variation	455:515	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	6	18	from	bioavailability	1329:1343	arg1	body					1376:1379	human body	1370:1379	human body	1370:1379	In conclusion, above results provide the experimental basis for the application of microgel encapsulation to improve the bioavailability of phenolic compounds in human body.
33049889	5	19	theme	digestive	990:998	arg1	phase					1000:1004	different digestive phase	980:1004	different digestive phase	980:1004	Nevertheless, during different digestive phase, the phenolic composition of microgel was significantly different from the one of untreated JRP, suggesting that JRP-Microgel could prevent the degradation of JRP induced by gastrointestinal digestion.
33049889	2	20	dep	regular	662:668	arg1	spherical					670:678	spherical	670:678	spherical	670:678	The results showed that JRP-Microgel belonged to semi-crystalline substances, and presented regular spherical or subspherical shape with neat edge and uniform particle size.
33049889	3	21	theme	physicochemical	774:788	arg1	stabilities					790:800	better physicochemical stabilities	767:800	better physicochemical stabilities	767:800	JRP-Microgel possessed better physicochemical stabilities compared with unencapsulated JRP.
33049889	2	22	theme	regular	662:668	arg1	shape					696:700	regular spherical or subspherical shape	662:700	regular spherical or subspherical shape	662:700	The results showed that JRP-Microgel belonged to semi-crystalline substances, and presented regular spherical or subspherical shape with neat edge and uniform particle size.
33049889	1	23	theme	characteristic	467:480	arg1	variation					507:515	the release characteristic and phenolic composition variation	455:515	the release characteristic and phenolic composition variation	455:515	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	0	24	dep	Jughans	87:93	arg1	L.					101:102	Jughans regia L.	87:102	Jughans regia L. polyphenols	87:114	Development of the pH responsive chitosan-alginate based microgel for encapsulation of Jughans regia L. polyphenols under simulated gastrointestinal digestion in vitro.
33049889	6	25	theme	microgel	1291:1298	arg1	encapsulation					1300:1312	microgel encapsulation	1291:1312	microgel encapsulation	1291:1312	In conclusion, above results provide the experimental basis for the application of microgel encapsulation to improve the bioavailability of phenolic compounds in human body.
33049889	0	26	theme	gastrointestinal	132:147	arg1	digestion					149:157	simulated gastrointestinal digestion	122:157	simulated gastrointestinal digestion	122:157	Development of the pH responsive chitosan-alginate based microgel for encapsulation of Jughans regia L. polyphenols under simulated gastrointestinal digestion in vitro.
33049889	1	27	theme	phenolic	486:493	arg1	variation					507:515	the release characteristic and phenolic composition variation	455:515	the release characteristic and phenolic composition variation	455:515	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	1	28	dep	Juglans	340:346	arg1	regia					348:352	regia	348:352	regia	348:352	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	0	29	theme	simulated	122:130	arg1	digestion					149:157	simulated gastrointestinal digestion	122:157	simulated gastrointestinal digestion	122:157	Development of the pH responsive chitosan-alginate based microgel for encapsulation of Jughans regia L. polyphenols under simulated gastrointestinal digestion in vitro.
33049889	6	30	theme	above	1223:1227	arg1	results					1229:1235	above results	1223:1235	above results	1223:1235	In conclusion, above results provide the experimental basis for the application of microgel encapsulation to improve the bioavailability of phenolic compounds in human body.
33049889	0	31	theme	chitosan-alginate	33:49	arg1	Development					0:10	Development	0:10	Development of the pH responsive chitosan-alginate	0:49	Development of the pH responsive chitosan-alginate based microgel for encapsulation of Jughans regia L. polyphenols under simulated gastrointestinal digestion in vitro.
33049889	3	32	theme	unencapsulated	816:829	arg1	JRP					831:833	unencapsulated JRP	816:833	unencapsulated JRP	816:833	JRP-Microgel possessed better physicochemical stabilities compared with unencapsulated JRP.
33049889	4	33	theme	simulated	921:929	arg1	digestion					948:956	simulated gastrointestinal digestion	921:956	simulated gastrointestinal digestion	921:956	Furthermore, JRP-Microgel exhibited excellent sustained release characteristic under simulated gastrointestinal digestion.
33049889	1	34	theme	novel	218:222	arg1	microgel					238:245	a novel pH-responsive microgel	216:245	a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro	216:567	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	0	35	theme	responsive	22:31	arg1	chitosan-alginate					33:49	the pH responsive chitosan-alginate	15:49	the pH responsive chitosan-alginate	15:49	Development of the pH responsive chitosan-alginate based microgel for encapsulation of Jughans regia L. polyphenols under simulated gastrointestinal digestion in vitro.
33049889	1	36	theme	composition	495:505	arg1	variation					507:515	the release characteristic and phenolic composition variation	455:515	the release characteristic and phenolic composition variation	455:515	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	1	37	theme	pH-responsive	224:236	arg1	microgel					238:245	a novel pH-responsive microgel	216:245	a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro	216:567	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	1	38	theme	physicochemical	393:407	arg1	properties					409:418	the physicochemical properties	389:418	the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro	389:567	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	5	39	theme	microgel	1035:1042	arg1	composition					1020:1030	the phenolic composition	1007:1030	the phenolic composition of microgel	1007:1042	Nevertheless, during different digestive phase, the phenolic composition of microgel was significantly different from the one of untreated JRP, suggesting that JRP-Microgel could prevent the degradation of JRP induced by gastrointestinal digestion.
33049889	5	39	theme	microgel	1035:1042	arg1	different					1062:1070	different	1062:1070	different	1062:1070	Nevertheless, during different digestive phase, the phenolic composition of microgel was significantly different from the one of untreated JRP, suggesting that JRP-Microgel could prevent the degradation of JRP induced by gastrointestinal digestion.
33049889	5	40	theme	JRP	1165:1167	arg1	degradation					1150:1160	the degradation	1146:1160	the degradation of JRP induced by gastrointestinal digestion	1146:1205	Nevertheless, during different digestive phase, the phenolic composition of microgel was significantly different from the one of untreated JRP, suggesting that JRP-Microgel could prevent the degradation of JRP induced by gastrointestinal digestion.
33049889	4	41	theme	gastrointestinal	931:946	arg1	digestion					948:956	simulated gastrointestinal digestion	921:956	simulated gastrointestinal digestion	921:956	Furthermore, JRP-Microgel exhibited excellent sustained release characteristic under simulated gastrointestinal digestion.
33049889	5	42	from	one	1081:1083	arg1	composition					1020:1030	the phenolic composition	1007:1030	the phenolic composition of microgel	1007:1042	Nevertheless, during different digestive phase, the phenolic composition of microgel was significantly different from the one of untreated JRP, suggesting that JRP-Microgel could prevent the degradation of JRP induced by gastrointestinal digestion.
33049889	5	42	from	one	1081:1083	arg1	different					1062:1070	different	1062:1070	different	1062:1070	Nevertheless, during different digestive phase, the phenolic composition of microgel was significantly different from the one of untreated JRP, suggesting that JRP-Microgel could prevent the degradation of JRP induced by gastrointestinal digestion.
33049889	2	43	theme	particle	729:736	arg1	size					738:741	uniform particle size	721:741	uniform particle size	721:741	The results showed that JRP-Microgel belonged to semi-crystalline substances, and presented regular spherical or subspherical shape with neat edge and uniform particle size.
33049889	4	44	theme	sustained	882:890	arg1	characteristic					900:913	excellent sustained release characteristic	872:913	excellent sustained release characteristic	872:913	Furthermore, JRP-Microgel exhibited excellent sustained release characteristic under simulated gastrointestinal digestion.
33049889	1	45	theme	simulated	523:531	arg1	digestion					550:558	simulated gastrointestinal digestion	523:558	simulated gastrointestinal digestion	523:558	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	6	46	theme	compounds	1357:1365	arg1	bioavailability					1329:1343	the bioavailability	1325:1343	the bioavailability of phenolic compounds in human body	1325:1379	In conclusion, above results provide the experimental basis for the application of microgel encapsulation to improve the bioavailability of phenolic compounds in human body.
33049889	1	47	theme	JRP-Microgel	423:434	arg1	properties					409:418	the physicochemical properties	389:418	the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro	389:567	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	4	48	theme	excellent	872:880	arg1	characteristic					900:913	excellent sustained release characteristic	872:913	excellent sustained release characteristic	872:913	Furthermore, JRP-Microgel exhibited excellent sustained release characteristic under simulated gastrointestinal digestion.
33049889	1	49	theme	gastrointestinal	533:548	arg1	digestion					550:558	simulated gastrointestinal digestion	523:558	simulated gastrointestinal digestion	523:558	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	6	50	theme	experimental	1249:1260	arg1	basis					1262:1266	the experimental basis	1245:1266	the experimental basis for the application of microgel encapsulation to improve the bioavailability of phenolic compounds in human body	1245:1379	In conclusion, above results provide the experimental basis for the application of microgel encapsulation to improve the bioavailability of phenolic compounds in human body.
33049889	6	51	theme	phenolic	1348:1355	arg1	compounds					1357:1365	phenolic compounds	1348:1365	phenolic compounds	1348:1365	In conclusion, above results provide the experimental basis for the application of microgel encapsulation to improve the bioavailability of phenolic compounds in human body.
33049889	1	52	theme	Juglans	340:346	arg1	L					354:354	Juglans regia L	340:354	Juglans regia L. (JRP-Microgel)	340:370	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	1	52	theme	Juglans	340:346	arg1	JRP-Microgel					358:369	JRP-Microgel	358:369	JRP-Microgel	358:369	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	4	53	theme	release	892:898	arg1	characteristic					900:913	excellent sustained release characteristic	872:913	excellent sustained release characteristic	872:913	Furthermore, JRP-Microgel exhibited excellent sustained release characteristic under simulated gastrointestinal digestion.
33049889	6	54	theme	human	1370:1374	arg1	body					1376:1379	human body	1370:1379	human body	1370:1379	In conclusion, above results provide the experimental basis for the application of microgel encapsulation to improve the bioavailability of phenolic compounds in human body.
33049889	5	55	theme	phenolic	1011:1018	arg1	composition					1020:1030	the phenolic composition	1007:1030	the phenolic composition of microgel	1007:1042	Nevertheless, during different digestive phase, the phenolic composition of microgel was significantly different from the one of untreated JRP, suggesting that JRP-Microgel could prevent the degradation of JRP induced by gastrointestinal digestion.
33049889	5	55	theme	phenolic	1011:1018	arg1	different					1062:1070	different	1062:1070	different	1062:1070	Nevertheless, during different digestive phase, the phenolic composition of microgel was significantly different from the one of untreated JRP, suggesting that JRP-Microgel could prevent the degradation of JRP induced by gastrointestinal digestion.
33049889	1	56	theme	chitosan/sodium	256:270	arg1	CS/ALG					282:287	CS/ALG	282:287	CS/ALG	282:287	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
33049889	1	56	theme	chitosan/sodium	256:270	arg1	alginate					272:279	chitosan/sodium alginate	256:279	chitosan/sodium alginate (CS/ALG)	256:288	The present research was designed to fabricate a novel pH-responsive microgel based on chitosan/sodium alginate (CS/ALG) to encapsulate the polyphenols from the shells of Juglans regia L. (JRP-Microgel), and investigate the physicochemical properties of JRP-Microgel as well as analyze the release characteristic and phenolic composition variation under simulated gastrointestinal digestion in vitro.
34118741	0	0	theme	fast	98:101	arg1	ball					114:117	fast and facile ball	98:117	fast and facile ball	98:117	Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball mill-assisted alkaline peroxide pretreatment.
34118741	1	1	theme	fermentable	350:360	arg1	sugars					362:367	fermentable sugars	350:367	fermentable sugars	350:367	The aim of this work was to develop a feasible ball mill-assisted alkaline peroxide pretreatment followed by stepwise hydrolysis to improve the yield of xylo-oligosaccharides (XOS) and fermentable sugars.
34118741	2	2	theme	hydrogen	374:381	arg1	peroxide					383:390	The hydrogen peroxide	370:390	The hydrogen peroxide charge	370:397	The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency.
34118741	2	3	theme	following	561:569	arg1	efficiency					582:591	the following hydrolytic efficiency	557:591	the following hydrolytic efficiency	557:591	The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency.
34118741	1	4	theme	sugars	362:367	arg1	yield					309:313	the yield	305:313	the yield of xylo-oligosaccharides (XOS) and fermentable sugars	305:367	The aim of this work was to develop a feasible ball mill-assisted alkaline peroxide pretreatment followed by stepwise hydrolysis to improve the yield of xylo-oligosaccharides (XOS) and fermentable sugars.
34118741	5	5	theme	two-step	939:946	arg1	hydrolysis					967:976	the two-step xylanase-cellulase hydrolysis	935:976	the two-step xylanase-cellulase hydrolysis of the pretreated corn stover	935:1006	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	1	6	theme	stepwise	274:281	arg1	hydrolysis					283:292	stepwise hydrolysis	274:292	stepwise hydrolysis	274:292	The aim of this work was to develop a feasible ball mill-assisted alkaline peroxide pretreatment followed by stepwise hydrolysis to improve the yield of xylo-oligosaccharides (XOS) and fermentable sugars.
34118741	0	7	theme	facile	107:112	arg1	ball					114:117	fast and facile ball	98:117	fast and facile ball	98:117	Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball mill-assisted alkaline peroxide pretreatment.
34118741	3	8	theme	1.0 h	695:699	arg1	ball-milling					701:712	1.0 h ball-milling	695:712	1.0 h ball-milling	695:712	The optimal pretreatment was with 0.45 g/g (H2O2: substrate) and 1:3 solid-to-liquid ratio (w/v) for 1.0 h ball-milling, resulting in 84.29% delignification.
34118741	6	9	theme	previous	1259:1266	arg1	studies					1268:1274	previous studies	1259:1274	previous studies	1259:1274	The yield of XOS was 2-7 times higher than those in previous studies.
34118741	6	10	theme	XOS	1220:1222	arg1	yield					1211:1215	The yield	1207:1215	The yield of XOS	1207:1222	The yield of XOS was 2-7 times higher than those in previous studies.
34118741	6	10	theme	XOS	1220:1222	arg1	higher					1238:1243	higher	1238:1243	higher	1238:1243	The yield of XOS was 2-7 times higher than those in previous studies.
34118741	5	11	theme	corn	996:999	arg1	stover					1001:1006	the pretreated corn stover	981:1006	the pretreated corn stover	981:1006	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	3	12	theme	84.29	728:732	arg1	%					733:733	%	733:733	%	733:733	The optimal pretreatment was with 0.45 g/g (H2O2: substrate) and 1:3 solid-to-liquid ratio (w/v) for 1.0 h ball-milling, resulting in 84.29% delignification.
34118741	2	13	theme	stover	530:535	arg1	morphology					488:497	morphology	488:497	morphology	488:497	The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency.
34118741	2	13	theme	stover	530:535	arg1	compositions					458:469	compositions	458:469	compositions	458:469	The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency.
34118741	2	13	theme	stover	530:535	arg1	sizes					481:485	particle sizes	472:485	particle sizes	472:485	The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency.
34118741	2	13	theme	stover	530:535	arg1	crystallinity					504:516	crystallinity	504:516	crystallinity	504:516	The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency.
34118741	3	14	theme	%	733:733	arg1	delignification					735:749	84.29% delignification	728:749	84.29% delignification	728:749	The optimal pretreatment was with 0.45 g/g (H2O2: substrate) and 1:3 solid-to-liquid ratio (w/v) for 1.0 h ball-milling, resulting in 84.29% delignification.
34118741	2	15	dep	compositions	458:469	arg1	the					454:456	the	454:456	the	454:456	The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency.
34118741	3	16	dep	H2O2	638:641	arg1	substrate					644:652	substrate	644:652	H2O2: substrate	638:652	The optimal pretreatment was with 0.45 g/g (H2O2: substrate) and 1:3 solid-to-liquid ratio (w/v) for 1.0 h ball-milling, resulting in 84.29% delignification.
34118741	4	17	theme	samples	797:803	arg1	properties					768:777	Physicochemical properties	752:777	Physicochemical properties of the pretreated samples	752:803	Physicochemical properties of the pretreated samples were characterized and their correlations to the enzymatic hydrolysis were revealed.
34118741	5	18	theme	one-step	904:911	arg1	hydrolysis					923:932	one-step cellulase hydrolysis	904:932	one-step cellulase hydrolysis	904:932	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	1	19	theme	work	181:184	arg1	aim					169:171	The aim	165:171	The aim of this work	165:184	The aim of this work was to develop a feasible ball mill-assisted alkaline peroxide pretreatment followed by stepwise hydrolysis to improve the yield of xylo-oligosaccharides (XOS) and fermentable sugars.
34118741	2	20	theme	corn	525:528	arg1	stover					530:535	the corn stover	521:535	the corn stover	521:535	The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency.
34118741	4	21	theme	pretreated	786:795	arg1	samples					797:803	the pretreated samples	782:803	the pretreated samples	782:803	Physicochemical properties of the pretreated samples were characterized and their correlations to the enzymatic hydrolysis were revealed.
34118741	2	22	theme	particle	472:479	arg1	sizes					481:485	particle sizes	472:485	particle sizes	472:485	The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency.
34118741	5	23	theme	pretreated	985:994	arg1	stover					1001:1006	the pretreated corn stover	981:1006	the pretreated corn stover	981:1006	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	5	24	theme	XOS	1125:1127	arg1	XOS					1125:1127	XOS	1125:1127	XOS	1125:1127	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	5	24	theme	XOS	1125:1127	arg1	%					1068:1068	69.65%	1063:1068	69.65% (on the base of xylan content in pretreated sample) of XOS	1063:1127	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	2	25	theme	ball-milling	400:411	arg1	time					413:416	ball-milling time	400:416	ball-milling time	400:416	The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency.
34118741	5	26	dep	%	1146:1146	arg1	xylose					1148:1153	xylose	1148:1153	20.55% xylose	1141:1153	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	3	27	theme	optimal	598:604	arg1	pretreatment					606:617	The optimal pretreatment	594:617	The optimal pretreatment	594:617	The optimal pretreatment was with 0.45 g/g (H2O2: substrate) and 1:3 solid-to-liquid ratio (w/v) for 1.0 h ball-milling, resulting in 84.29% delignification.
34118741	3	28	dep	0.45 g/g	628:635	arg1	H2O2					638:641	H2O2	638:641	H2O2: substrate	638:652	The optimal pretreatment was with 0.45 g/g (H2O2: substrate) and 1:3 solid-to-liquid ratio (w/v) for 1.0 h ball-milling, resulting in 84.29% delignification.
34118741	0	29	theme	xylo-oligosaccharides	28:48	arg1	Co-production					0:12	Co-production	0:12	Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball	0:117	Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball mill-assisted alkaline peroxide pretreatment.
34118741	0	30	theme	peroxide	142:149	arg1	pretreatment					151:162	alkaline peroxide pretreatment	133:162	alkaline peroxide pretreatment	133:162	Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball mill-assisted alkaline peroxide pretreatment.
34118741	5	31	theme	stover	1001:1006	arg1	hydrolysis					967:976	the two-step xylanase-cellulase hydrolysis	935:976	the two-step xylanase-cellulase hydrolysis of the pretreated corn stover	935:1006	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	0	32	theme	functional	17:26	arg1	xylo-oligosaccharides					28:48	functional xylo-oligosaccharides	17:48	functional xylo-oligosaccharides	17:48	Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball mill-assisted alkaline peroxide pretreatment.
34118741	0	33	theme	alkaline	133:140	arg1	pretreatment					151:162	alkaline peroxide pretreatment	133:162	alkaline peroxide pretreatment	133:162	Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball mill-assisted alkaline peroxide pretreatment.
34118741	4	34	theme	Physicochemical	752:766	arg1	properties					768:777	Physicochemical properties	752:777	Physicochemical properties of the pretreated samples	752:803	Physicochemical properties of the pretreated samples were characterized and their correlations to the enzymatic hydrolysis were revealed.
34118741	5	35	from	%	1068:1068	arg1	base					1078:1081	the base	1074:1081	the base of xylan content in pretreated sample	1074:1119	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	1	36	theme	feasible	203:210	arg1	ball					212:215	a feasible ball	201:215	a feasible ball	201:215	The aim of this work was to develop a feasible ball mill-assisted alkaline peroxide pretreatment followed by stepwise hydrolysis to improve the yield of xylo-oligosaccharides (XOS) and fermentable sugars.
34118741	0	37	theme	fermentable	54:64	arg1	sugars					66:71	fermentable sugars	54:71	fermentable sugars	54:71	Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball mill-assisted alkaline peroxide pretreatment.
34118741	3	38	theme	solid-to-liquid	663:677	arg1	w/v					686:688	w/v	686:688	w/v	686:688	The optimal pretreatment was with 0.45 g/g (H2O2: substrate) and 1:3 solid-to-liquid ratio (w/v) for 1.0 h ball-milling, resulting in 84.29% delignification.
34118741	3	38	theme	solid-to-liquid	663:677	arg1	ratio					679:683	1:3 solid-to-liquid ratio	659:683	1:3 solid-to-liquid ratio (w/v) for 1.0 h ball-milling	659:712	The optimal pretreatment was with 0.45 g/g (H2O2: substrate) and 1:3 solid-to-liquid ratio (w/v) for 1.0 h ball-milling, resulting in 84.29% delignification.
34118741	5	39	theme	cellulase	913:921	arg1	hydrolysis					923:932	one-step cellulase hydrolysis	904:932	one-step cellulase hydrolysis	904:932	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	2	40	theme	solid-to-liquid	423:437	arg1	ratio					439:443	solid-to-liquid ratio	423:443	solid-to-liquid ratio	423:443	The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency.
34118741	1	41	theme	xylo-oligosaccharides	318:338	arg1	yield					309:313	the yield	305:313	the yield of xylo-oligosaccharides (XOS) and fermentable sugars	305:367	The aim of this work was to develop a feasible ball mill-assisted alkaline peroxide pretreatment followed by stepwise hydrolysis to improve the yield of xylo-oligosaccharides (XOS) and fermentable sugars.
34118741	0	42	from	stover	83:88	arg1	Co-production					0:12	Co-production	0:12	Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball	0:117	Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball mill-assisted alkaline peroxide pretreatment.
34118741	1	43	dep	develop	193:199	arg1	followed					262:269	followed	262:269	followed by stepwise hydrolysis to improve the yield of xylo-oligosaccharides (XOS) and fermentable sugars	262:367	The aim of this work was to develop a feasible ball mill-assisted alkaline peroxide pretreatment followed by stepwise hydrolysis to improve the yield of xylo-oligosaccharides (XOS) and fermentable sugars.
34118741	1	44	theme	mill-assisted	217:229	arg1	pretreatment					249:260	mill-assisted alkaline peroxide pretreatment	217:260	mill-assisted alkaline peroxide pretreatment	217:260	The aim of this work was to develop a feasible ball mill-assisted alkaline peroxide pretreatment followed by stepwise hydrolysis to improve the yield of xylo-oligosaccharides (XOS) and fermentable sugars.
34118741	5	45	theme	68.94	1156:1160	arg1	%					1161:1161	%	1161:1161	%	1161:1161	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	5	46	from	sample	1114:1119	arg1	base					1078:1081	the base	1074:1081	the base of xylan content in pretreated sample	1074:1119	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	5	47	from	content	1092:1098	arg1	sample					1114:1119	pretreated sample	1103:1119	pretreated sample	1103:1119	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	4	48	theme	enzymatic	854:862	arg1	hydrolysis					864:873	the enzymatic hydrolysis	850:873	the enzymatic hydrolysis	850:873	Physicochemical properties of the pretreated samples were characterized and their correlations to the enzymatic hydrolysis were revealed.
34118741	5	49	theme	xylanase-cellulase	948:965	arg1	hydrolysis					967:976	the two-step xylanase-cellulase hydrolysis	935:976	the two-step xylanase-cellulase hydrolysis of the pretreated corn stover	935:1006	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	0	50	theme	sugars	66:71	arg1	Co-production					0:12	Co-production	0:12	Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball	0:117	Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball mill-assisted alkaline peroxide pretreatment.
34118741	5	51	theme	%	1161:1161	arg1	glucose					1163:1169	68.94% glucose	1156:1169	68.94% glucose	1156:1169	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	2	52	theme	hydrolytic	571:580	arg1	efficiency					582:591	the following hydrolytic efficiency	557:591	the following hydrolytic efficiency	557:591	The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency.
34118741	5	53	dep	%	1068:1068	arg1	gluco-oligosaccharides					1183:1204	gluco-oligosaccharides	1183:1204	gluco-oligosaccharides	1183:1204	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	5	54	dep	significant	1015:1025	arg1	advance					1027:1033	advance	1027:1033	advance	1027:1033	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	1	55	theme	alkaline	231:238	arg1	pretreatment					249:260	mill-assisted alkaline peroxide pretreatment	217:260	mill-assisted alkaline peroxide pretreatment	217:260	The aim of this work was to develop a feasible ball mill-assisted alkaline peroxide pretreatment followed by stepwise hydrolysis to improve the yield of xylo-oligosaccharides (XOS) and fermentable sugars.
34118741	5	56	theme	xylan	1086:1090	arg1	content					1092:1098	xylan content	1086:1098	xylan content in pretreated sample	1086:1119	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	5	57	theme	pretreated	1103:1112	arg1	sample					1114:1119	pretreated sample	1103:1119	pretreated sample	1103:1119	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	1	58	theme	peroxide	240:247	arg1	pretreatment					249:260	mill-assisted alkaline peroxide pretreatment	217:260	mill-assisted alkaline peroxide pretreatment	217:260	The aim of this work was to develop a feasible ball mill-assisted alkaline peroxide pretreatment followed by stepwise hydrolysis to improve the yield of xylo-oligosaccharides (XOS) and fermentable sugars.
34118741	5	59	theme	content	1092:1098	arg1	base					1078:1081	the base	1074:1081	the base of xylan content in pretreated sample	1074:1119	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	0	60	theme	corn	78:81	arg1	stover					83:88	corn stover	78:88	corn stover through fast and facile ball	78:117	Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball mill-assisted alkaline peroxide pretreatment.
34118741	5	61	from	base	1078:1081	arg1	sample					1114:1119	pretreated sample	1103:1119	pretreated sample	1103:1119	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34118741	2	62	theme	peroxide	383:390	arg1	charge					392:397	The hydrogen peroxide charge	370:397	The hydrogen peroxide charge	370:397	The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency.
34118741	5	63	dep	along	1130:1134	arg1	with					1136:1139	with	1136:1139	with	1136:1139	Compared with one-step cellulase hydrolysis, the two-step xylanase-cellulase hydrolysis of the pretreated corn stover showed significant advance in preparing XOS, producing 69.65% (on the base of xylan content in pretreated sample) of XOS, along with 20.55% xylose, 68.94% glucose, and 21.15% gluco-oligosaccharides.
34210426	0	0	theme	based	53:57	arg1	composites					59:68	loaded chitosan based composites	37:68	loaded chitosan based composites	37:68	High phosphate removal using La(OH)3 loaded chitosan based composites and mechanistic study.
34210426	7	1	theme	bed	1153:1155	arg1	volumes					1157:1163	1300 bed volumes	1148:1163	1300 bed volumes (BV)	1148:1168	The column adsorption capacity reached 1300 bed volumes (BV) when phosphate concentration decreased until 0.5 mg/L at 6 BV/hr.
34210426	7	1	theme	bed	1153:1155	arg1	BV					1166:1167	BV	1166:1167	BV	1166:1167	The column adsorption capacity reached 1300 bed volumes (BV) when phosphate concentration decreased until 0.5 mg/L at 6 BV/hr.
34210426	4	2	theme	nano-sized	644:653	arg1	OH					658:659	immobilizing nano-sized La(OH)3	631:661	immobilizing nano-sized La(OH)3	631:661	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	1	3	theme	accelerated	223:233	arg1	eutrophication					235:248	the accelerated eutrophication	219:248	the accelerated eutrophication in water body	219:262	Our present study was to prepare a biomass-supported adsorbents with high adsorptive capacity and high selectivity to prevent the accelerated eutrophication in water body.
34210426	0	4	theme	chitosan	44:51	arg1	composites					59:68	loaded chitosan based composites	37:68	loaded chitosan based composites	37:68	High phosphate removal using La(OH)3 loaded chitosan based composites and mechanistic study.
34210426	4	5	contain	has	582:584	arg2	adsorption					593:602	strong adsorption	586:602	strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3	586:661	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	4	5	contain	has	582:584	arg1	%					566:566	chitosan-La(OH)3-quaternary ammonium-20%	527:566	chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%)	527:580	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	4	5	contain	has	582:584	arg1	%					579:579	CS-La-N-20%	569:579	CS-La-N-20%	569:579	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	8	6	theme	use	1368:1370	arg1	property					1372:1379	repeated use property	1359:1379	repeated use property	1359:1379	The column adsorption/desorption reveals that no significant capacity loss is observed, indicating excellent stability and repeated use property.
34210426	8	7	theme	repeated	1359:1366	arg1	property					1372:1379	repeated use property	1359:1379	repeated use property	1359:1379	The column adsorption/desorption reveals that no significant capacity loss is observed, indicating excellent stability and repeated use property.
34210426	8	8	theme	significant	1285:1295	arg1	loss					1306:1309	no significant capacity loss	1282:1309	no significant capacity loss	1282:1309	The column adsorption/desorption reveals that no significant capacity loss is observed, indicating excellent stability and repeated use property.
34210426	6	9	theme	unmodified	1063:1072	arg1	adsorbents					1074:1083	the unmodified adsorbents	1059:1083	the unmodified adsorbents	1059:1083	What's more, adsorption capacity on the introduce of positively charged quanternary-aminated groups was significantly higher than that of the unmodified adsorbents at alkaline conditions.
34210426	5	10	theme	pH	861:862	arg1	range					864:868	a wide pH range	854:868	a wide pH range between 3 and 7 without significant La3+ leaching	854:918	The pH results indicated that the CS-La-N-20% would effectively sequestrate phosphate over a wide pH range between 3 and 7 without significant La3+ leaching.
34210426	6	11	dep	more	928:931	arg1	's					925:926	's	925:926	's	925:926	What's more, adsorption capacity on the introduce of positively charged quanternary-aminated groups was significantly higher than that of the unmodified adsorbents at alkaline conditions.
34210426	9	12	theme	electrostatic	1505:1517	arg1	groups					1571:1576	positively charged quanternary-aminated groups	1531:1576	positively charged quanternary-aminated groups	1531:1576	Characterizations revealed that phosphate adsorption on CS-La-N-20% through ligand exchange (impregnated nano-La(OH)3) and electrostatic attraction (positively charged quanternary-aminated groups).
34210426	9	12	theme	electrostatic	1505:1517	arg1	attraction					1519:1528	electrostatic attraction	1505:1528	electrostatic attraction (positively charged quanternary-aminated groups)	1505:1577	Characterizations revealed that phosphate adsorption on CS-La-N-20% through ligand exchange (impregnated nano-La(OH)3) and electrostatic attraction (positively charged quanternary-aminated groups).
34210426	1	13	theme	water	253:257	arg1	body					259:262	water body	253:262	water body	253:262	Our present study was to prepare a biomass-supported adsorbents with high adsorptive capacity and high selectivity to prevent the accelerated eutrophication in water body.
34210426	7	14	theme	adsorption	1120:1129	arg1	capacity					1131:1138	The column adsorption capacity	1109:1138	The column adsorption capacity	1109:1138	The column adsorption capacity reached 1300 bed volumes (BV) when phosphate concentration decreased until 0.5 mg/L at 6 BV/hr.
34210426	10	15	theme	phosphate	1673:1681	arg1	removal					1683:1689	preferable phosphate removal	1662:1689	preferable phosphate removal in realistic application	1662:1714	All the results suggested that CS-La-N-20% can serve as a promising adsorbent for preferable phosphate removal in realistic application.
34210426	6	16	theme	quanternary-aminated	993:1012	arg1	groups					1014:1019	positively charged quanternary-aminated groups	974:1019	positively charged quanternary-aminated groups	974:1019	What's more, adsorption capacity on the introduce of positively charged quanternary-aminated groups was significantly higher than that of the unmodified adsorbents at alkaline conditions.
34210426	9	17	theme	charged	1542:1548	arg1	groups					1571:1576	positively charged quanternary-aminated groups	1531:1576	positively charged quanternary-aminated groups	1531:1576	Characterizations revealed that phosphate adsorption on CS-La-N-20% through ligand exchange (impregnated nano-La(OH)3) and electrostatic attraction (positively charged quanternary-aminated groups).
34210426	9	17	theme	charged	1542:1548	arg1	attraction					1519:1528	electrostatic attraction	1505:1528	electrostatic attraction (positively charged quanternary-aminated groups)	1505:1577	Characterizations revealed that phosphate adsorption on CS-La-N-20% through ligand exchange (impregnated nano-La(OH)3) and electrostatic attraction (positively charged quanternary-aminated groups).
34210426	1	18	theme	biomass-supported	128:144	arg1	adsorbents					146:155	a biomass-supported adsorbents	126:155	a biomass-supported adsorbents with high adsorptive capacity and high selectivity to prevent the accelerated eutrophication in water body	126:262	Our present study was to prepare a biomass-supported adsorbents with high adsorptive capacity and high selectivity to prevent the accelerated eutrophication in water body.
34210426	0	19	theme	mechanistic	74:84	arg1	study					86:90	mechanistic study	74:90	mechanistic study	74:90	High phosphate removal using La(OH)3 loaded chitosan based composites and mechanistic study.
34210426	6	20	dep	the	957:959	arg1	introduce					961:969	introduce	961:969	introduce	961:969	What's more, adsorption capacity on the introduce of positively charged quanternary-aminated groups was significantly higher than that of the unmodified adsorbents at alkaline conditions.
34210426	8	21	theme	capacity	1297:1304	arg1	loss					1306:1309	no significant capacity loss	1282:1309	no significant capacity loss	1282:1309	The column adsorption/desorption reveals that no significant capacity loss is observed, indicating excellent stability and repeated use property.
34210426	5	22	theme	significant	894:904	arg1	leaching					911:918	significant La3+ leaching	894:918	significant La3+ leaching	894:918	The pH results indicated that the CS-La-N-20% would effectively sequestrate phosphate over a wide pH range between 3 and 7 without significant La3+ leaching.
34210426	3	23	theme	ammonium	396:403	arg1	group					405:409	Then the quaternary ammonium group	376:409	Then the quaternary ammonium group with different content	376:432	Then the quaternary ammonium group with different content was introduced into the adsorbent by polymerization.
34210426	0	24	theme	phosphate	5:13	arg1	removal					15:21	High phosphate removal	0:21	High phosphate removal	0:21	High phosphate removal using La(OH)3 loaded chitosan based composites and mechanistic study.
34210426	6	25	theme	alkaline	1088:1095	arg1	conditions					1097:1106	alkaline conditions	1088:1106	alkaline conditions	1088:1106	What's more, adsorption capacity on the introduce of positively charged quanternary-aminated groups was significantly higher than that of the unmodified adsorbents at alkaline conditions.
34210426	6	26	from	capacity	945:952	arg1	the					957:959	the	957:959	the	957:959	What's more, adsorption capacity on the introduce of positively charged quanternary-aminated groups was significantly higher than that of the unmodified adsorbents at alkaline conditions.
34210426	2	27	theme	metal	288:292	arg1	hydroxide					294:302	different metal hydroxide	278:302	different metal hydroxide (La, Zr and Fe)	278:318	To this end, different metal hydroxide (La, Zr and Fe) first was successfully loaded on chitosan microspheres.
34210426	9	28	theme	phosphate	1414:1422	arg1	adsorption					1424:1433	that phosphate adsorption	1409:1433	that phosphate adsorption	1409:1433	Characterizations revealed that phosphate adsorption on CS-La-N-20% through ligand exchange (impregnated nano-La(OH)3) and electrostatic attraction (positively charged quanternary-aminated groups).
34210426	0	29	theme	High	0:3	arg1	removal					15:21	High phosphate removal	0:21	High phosphate removal	0:21	High phosphate removal using La(OH)3 loaded chitosan based composites and mechanistic study.
34210426	2	30	theme	different	278:286	arg1	hydroxide					294:302	different metal hydroxide	278:302	different metal hydroxide (La, Zr and Fe)	278:318	To this end, different metal hydroxide (La, Zr and Fe) first was successfully loaded on chitosan microspheres.
34210426	1	31	theme	high	162:165	arg1	capacity					178:185	high adsorptive capacity	162:185	high adsorptive capacity	162:185	Our present study was to prepare a biomass-supported adsorbents with high adsorptive capacity and high selectivity to prevent the accelerated eutrophication in water body.
34210426	4	32	theme	properties	515:524	arg1	comparison					490:499	comparison	490:499	comparison of adsorption properties	490:524	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	3	33	with	group	405:409	arg1	content					426:432	different content	416:432	different content	416:432	Then the quaternary ammonium group with different content was introduced into the adsorbent by polymerization.
34210426	4	34	theme	quaternary-aminated	672:690	arg1	chitosan					692:699	a quaternary-aminated chitosan	670:699	a quaternary-aminated chitosan	670:699	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	1	35	theme	adsorptive	167:176	arg1	capacity					178:185	high adsorptive capacity	162:185	high adsorptive capacity	162:185	Our present study was to prepare a biomass-supported adsorbents with high adsorptive capacity and high selectivity to prevent the accelerated eutrophication in water body.
34210426	2	36	dep	hydroxide	294:302	arg1	La					305:306	La	305:306	La	305:306	To this end, different metal hydroxide (La, Zr and Fe) first was successfully loaded on chitosan microspheres.
34210426	2	36	dep	hydroxide	294:302	arg1	Fe					316:317	Fe	316:317	Fe	316:317	To this end, different metal hydroxide (La, Zr and Fe) first was successfully loaded on chitosan microspheres.
34210426	2	36	dep	hydroxide	294:302	arg1	Zr					309:310	Zr	309:310	Zr	309:310	To this end, different metal hydroxide (La, Zr and Fe) first was successfully loaded on chitosan microspheres.
34210426	4	37	theme	immobilizing	631:642	arg1	OH					658:659	immobilizing nano-sized La(OH)3	631:661	immobilizing nano-sized La(OH)3	631:661	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	9	38	theme	nano-La	1487:1493	arg1	OH					1495:1496	impregnated nano-La(OH)3	1475:1498	impregnated nano-La(OH)3	1475:1498	Characterizations revealed that phosphate adsorption on CS-La-N-20% through ligand exchange (impregnated nano-La(OH)3) and electrostatic attraction (positively charged quanternary-aminated groups).
34210426	9	38	theme	nano-La	1487:1493	arg1	exchange					1465:1472	ligand exchange	1458:1472	ligand exchange (impregnated nano-La(OH)3)	1458:1499	Characterizations revealed that phosphate adsorption on CS-La-N-20% through ligand exchange (impregnated nano-La(OH)3) and electrostatic attraction (positively charged quanternary-aminated groups).
34210426	10	39	theme	preferable	1662:1671	arg1	removal					1683:1689	preferable phosphate removal	1662:1689	preferable phosphate removal in realistic application	1662:1714	All the results suggested that CS-La-N-20% can serve as a promising adsorbent for preferable phosphate removal in realistic application.
34210426	5	40	theme	pH	767:768	arg1	results					770:776	The pH results	763:776	The pH results	763:776	The pH results indicated that the CS-La-N-20% would effectively sequestrate phosphate over a wide pH range between 3 and 7 without significant La3+ leaching.
34210426	9	41	theme	quanternary-aminated	1550:1569	arg1	groups					1571:1576	positively charged quanternary-aminated groups	1531:1576	positively charged quanternary-aminated groups	1531:1576	Characterizations revealed that phosphate adsorption on CS-La-N-20% through ligand exchange (impregnated nano-La(OH)3) and electrostatic attraction (positively charged quanternary-aminated groups).
34210426	9	41	theme	quanternary-aminated	1550:1569	arg1	attraction					1519:1528	electrostatic attraction	1505:1528	electrostatic attraction (positively charged quanternary-aminated groups)	1505:1577	Characterizations revealed that phosphate adsorption on CS-La-N-20% through ligand exchange (impregnated nano-La(OH)3) and electrostatic attraction (positively charged quanternary-aminated groups).
34210426	2	42	theme	chitosan	353:360	arg1	microspheres					362:373	chitosan microspheres	353:373	chitosan microspheres	353:373	To this end, different metal hydroxide (La, Zr and Fe) first was successfully loaded on chitosan microspheres.
34210426	0	43	theme	La	29:30	arg1	OH					32:33	La(OH)3	29:35	La(OH)3	29:35	High phosphate removal using La(OH)3 loaded chitosan based composites and mechanistic study.
34210426	1	44	from	eutrophication	235:248	arg1	body					259:262	water body	253:262	water body	253:262	Our present study was to prepare a biomass-supported adsorbents with high adsorptive capacity and high selectivity to prevent the accelerated eutrophication in water body.
34210426	0	45	dep	OH	32:33	arg1	composites					59:68	loaded chitosan based composites	37:68	loaded chitosan based composites	37:68	High phosphate removal using La(OH)3 loaded chitosan based composites and mechanistic study.
34210426	1	46	theme	high	191:194	arg1	selectivity					196:206	high selectivity	191:206	high selectivity	191:206	Our present study was to prepare a biomass-supported adsorbents with high adsorptive capacity and high selectivity to prevent the accelerated eutrophication in water body.
34210426	10	47	theme	realistic	1694:1702	arg1	application					1704:1714	realistic application	1694:1714	realistic application	1694:1714	All the results suggested that CS-La-N-20% can serve as a promising adsorbent for preferable phosphate removal in realistic application.
34210426	3	48	theme	quaternary	385:394	arg1	group					405:409	Then the quaternary ammonium group	376:409	Then the quaternary ammonium group with different content	376:432	Then the quaternary ammonium group with different content was introduced into the adsorbent by polymerization.
34210426	4	49	theme	ions	757:760	arg1	presence					740:747	the presence	736:747	the presence of salt ions	736:760	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	9	50	theme	ligand	1458:1463	arg1	OH					1495:1496	impregnated nano-La(OH)3	1475:1498	impregnated nano-La(OH)3	1475:1498	Characterizations revealed that phosphate adsorption on CS-La-N-20% through ligand exchange (impregnated nano-La(OH)3) and electrostatic attraction (positively charged quanternary-aminated groups).
34210426	9	50	theme	ligand	1458:1463	arg1	exchange					1465:1472	ligand exchange	1458:1472	ligand exchange (impregnated nano-La(OH)3)	1458:1499	Characterizations revealed that phosphate adsorption on CS-La-N-20% through ligand exchange (impregnated nano-La(OH)3) and electrostatic attraction (positively charged quanternary-aminated groups).
34210426	9	51	theme	impregnated	1475:1485	arg1	OH					1495:1496	impregnated nano-La(OH)3	1475:1498	impregnated nano-La(OH)3	1475:1498	Characterizations revealed that phosphate adsorption on CS-La-N-20% through ligand exchange (impregnated nano-La(OH)3) and electrostatic attraction (positively charged quanternary-aminated groups).
34210426	9	51	theme	impregnated	1475:1485	arg1	exchange					1465:1472	ligand exchange	1458:1472	ligand exchange (impregnated nano-La(OH)3)	1458:1499	Characterizations revealed that phosphate adsorption on CS-La-N-20% through ligand exchange (impregnated nano-La(OH)3) and electrostatic attraction (positively charged quanternary-aminated groups).
34210426	4	52	theme	adsorption	504:513	arg1	properties					515:524	adsorption properties	504:524	adsorption properties	504:524	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	4	53	theme	salt	752:755	arg1	ions					757:760	salt ions	752:760	salt ions	752:760	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	4	54	theme	La	655:656	arg1	OH					658:659	immobilizing nano-sized La(OH)3	631:661	immobilizing nano-sized La(OH)3	631:661	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	10	55	from	removal	1683:1689	arg1	application					1704:1714	realistic application	1694:1714	realistic application	1694:1714	All the results suggested that CS-La-N-20% can serve as a promising adsorbent for preferable phosphate removal in realistic application.
34210426	5	56	theme	La3+	906:909	arg1	leaching					911:918	significant La3+ leaching	894:918	significant La3+ leaching	894:918	The pH results indicated that the CS-La-N-20% would effectively sequestrate phosphate over a wide pH range between 3 and 7 without significant La3+ leaching.
34210426	8	57	theme	excellent	1335:1343	arg1	stability					1345:1353	excellent stability	1335:1353	excellent stability	1335:1353	The column adsorption/desorption reveals that no significant capacity loss is observed, indicating excellent stability and repeated use property.
34210426	1	58	theme	present	97:103	arg1	study					105:109	Our present study	93:109	Our present study	93:109	Our present study was to prepare a biomass-supported adsorbents with high adsorptive capacity and high selectivity to prevent the accelerated eutrophication in water body.
34210426	6	59	theme	adsorption	934:943	arg1	capacity					945:952	adsorption capacity	934:952	adsorption capacity on the introduce of positively charged quanternary-aminated groups	934:1019	What's more, adsorption capacity on the introduce of positively charged quanternary-aminated groups was significantly higher than that of the unmodified adsorbents at alkaline conditions.
34210426	1	60	with	adsorbents	146:155	arg1	capacity					178:185	high adsorptive capacity	162:185	high adsorptive capacity	162:185	Our present study was to prepare a biomass-supported adsorbents with high adsorptive capacity and high selectivity to prevent the accelerated eutrophication in water body.
34210426	1	60	with	adsorbents	146:155	arg1	selectivity					196:206	high selectivity	191:206	high selectivity	191:206	Our present study was to prepare a biomass-supported adsorbents with high adsorptive capacity and high selectivity to prevent the accelerated eutrophication in water body.
34210426	4	61	theme	high	717:720	arg1	adsorption					722:731	high adsorption	717:731	high adsorption	717:731	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	5	62	theme	wide	856:859	arg1	range					864:868	a wide pH range	854:868	a wide pH range between 3 and 7 without significant La3+ leaching	854:918	The pH results indicated that the CS-La-N-20% would effectively sequestrate phosphate over a wide pH range between 3 and 7 without significant La3+ leaching.
34210426	0	63	theme	loaded	37:42	arg1	composites					59:68	loaded chitosan based composites	37:68	loaded chitosan based composites	37:68	High phosphate removal using La(OH)3 loaded chitosan based composites and mechanistic study.
34210426	4	64	theme	strong	586:591	arg1	adsorption					593:602	strong adsorption	586:602	strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3	586:661	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	3	65	theme	different	416:424	arg1	content					426:432	different content	416:432	different content	416:432	Then the quaternary ammonium group with different content was introduced into the adsorbent by polymerization.
34210426	7	66	theme	phosphate	1175:1183	arg1	concentration					1185:1197	phosphate concentration	1175:1197	phosphate concentration	1175:1197	The column adsorption capacity reached 1300 bed volumes (BV) when phosphate concentration decreased until 0.5 mg/L at 6 BV/hr.
34210426	6	67	theme	charged	985:991	arg1	groups					1014:1019	positively charged quanternary-aminated groups	974:1019	positively charged quanternary-aminated groups	974:1019	What's more, adsorption capacity on the introduce of positively charged quanternary-aminated groups was significantly higher than that of the unmodified adsorbents at alkaline conditions.
34210426	4	68	theme	3-quaternary	542:553	arg1	%					566:566	chitosan-La(OH)3-quaternary ammonium-20%	527:566	chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%)	527:580	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	4	68	theme	3-quaternary	542:553	arg1	%					579:579	CS-La-N-20%	569:579	CS-La-N-20%	569:579	By comparison of adsorption properties, chitosan-La(OH)3-quaternary ammonium-20% (CS-La-N-20%) has strong adsorption to phosphate (160 mg/g) by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt ions.
34210426	8	69	theme	column	1240:1245	arg1	adsorption/desorption					1247:1267	The column adsorption/desorption	1236:1267	The column adsorption/desorption	1236:1267	The column adsorption/desorption reveals that no significant capacity loss is observed, indicating excellent stability and repeated use property.
34210426	7	70	theme	column	1113:1118	arg1	capacity					1131:1138	The column adsorption capacity	1109:1138	The column adsorption capacity	1109:1138	The column adsorption capacity reached 1300 bed volumes (BV) when phosphate concentration decreased until 0.5 mg/L at 6 BV/hr.
34210426	7	71	theme	1300	1148:1151	arg1	volumes					1157:1163	1300 bed volumes	1148:1163	1300 bed volumes (BV)	1148:1168	The column adsorption capacity reached 1300 bed volumes (BV) when phosphate concentration decreased until 0.5 mg/L at 6 BV/hr.
34210426	7	71	theme	1300	1148:1151	arg1	BV					1166:1167	BV	1166:1167	BV	1166:1167	The column adsorption capacity reached 1300 bed volumes (BV) when phosphate concentration decreased until 0.5 mg/L at 6 BV/hr.
34816793	3	0	dep	HS	631:632	arg1	heat					625:628	cold (CS), heat (HS) and osmotic (OS) shocks	614:657	heat	625:628	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	1	1	theme	key	315:317	arg1	role					319:322	its key role	311:322	its key role in alkaliphilia	311:338	Previously, we showed for the first time that alkaliphilic fungi, in contrast to alkalitolerant fungi, accumulated trehalose under extremely alkaline conditions, and we have proposed its key role in alkaliphilia.
34816793	5	2	from	background	1054:1063	arg1	proportion					1086:1095	the proportion	1082:1095	the proportion of phosphatidic acids	1082:1117	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	6	3	from	increase	1232:1239	arg1	level					1248:1252	the level	1244:1252	the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS	1244:1358	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	6	3	from	increase	1232:1239	arg1	lipids					1179:1184	membrane lipids	1170:1184	membrane lipids	1170:1184	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	6	3	from	increase	1232:1239	arg1	amount					1160:1165	the amount	1156:1165	the amount	1156:1165	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	7	4	theme	composition	1399:1409	arg1	consistency					1380:1390	the observed consistency	1367:1390	the observed consistency of the composition of membrane lipids	1367:1428	Thus, the observed consistency of the composition of membrane lipids suggests that trehalose can participate in adaptation not only to extremely alkaline conditions, but also to other stressors - HS, CS and OS.
34816793	2	5	theme	alkaline	449:456	arg1	conditions					458:467	alkaline conditions	449:467	alkaline conditions	449:467	We propose that high levels of trehalose in the mycelium of alkaliphiles may promote adaptation not only to alkaline conditions, but also to other stressors.
34816793	0	6	from	lipid	9:13	arg1	tronii					84:89	the alkaliphilic micromycete Sodiomyces tronii	44:89	the alkaliphilic micromycete Sodiomyces tronii	44:89	Membrane lipid and osmolyte readjustment in the alkaliphilic micromycete Sodiomyces tronii under cold, heat and osmotic shocks.
34816793	8	7	theme	various	1663:1669	arg1	stressors					1671:1679	various stressors	1663:1679	various stressors	1663:1679	Taken together, the data obtained indicate the adaptability of the fungus to the action of various stressors, which can point to polyextremotolerance.
34816793	7	8	theme	lipids	1423:1428	arg1	composition					1399:1409	the composition	1395:1409	the composition of membrane lipids	1395:1428	Thus, the observed consistency of the composition of membrane lipids suggests that trehalose can participate in adaptation not only to extremely alkaline conditions, but also to other stressors - HS, CS and OS.
34816793	3	9	dep	cold	614:617	arg1	CS					620:621	CS	620:621	CS	620:621	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	3	10	from	lipids	587:592	arg1	composition					536:546	the composition	532:546	the composition of osmolytes	532:559	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	6	11	from	mycelium	1303:1310	arg1	level					1248:1252	the level	1244:1252	the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS	1244:1358	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	4	12	theme	unsaturation	773:784	arg1	degree					763:768	the degree	759:768	the degree of unsaturation of phospholipids	759:801	During adaptation to CS, an increase in the degree of unsaturation of phospholipids was observed while the composition of osmolytes, membrane and storage lipids remained the same.
34816793	5	13	theme	decrease	1070:1077	arg1	background					1054:1063	the background	1050:1063	the background of a decrease in the proportion of phosphatidic acids	1050:1117	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	5	14	theme	phosphatidic	1100:1111	arg1	acids					1113:1117	phosphatidic acids	1100:1117	phosphatidic acids	1100:1117	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	0	15	theme	cold	97:100	arg1	shocks					120:125	cold, heat and osmotic shocks	97:125	cold, heat and osmotic shocks	97:125	Membrane lipid and osmolyte readjustment in the alkaliphilic micromycete Sodiomyces tronii under cold, heat and osmotic shocks.
34816793	8	16	theme	fungus	1639:1644	arg1	adaptability					1619:1630	the adaptability	1615:1630	the adaptability of the fungus to the action of various stressors, which can point to polyextremotolerance	1615:1720	Taken together, the data obtained indicate the adaptability of the fungus to the action of various stressors, which can point to polyextremotolerance.
34816793	5	17	theme	acids	1113:1117	arg1	proportion					1086:1095	the proportion	1082:1095	the proportion of phosphatidic acids	1082:1117	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	3	18	theme	osmotic	639:645	arg1	shocks					652:657	cold (CS), heat (HS) and osmotic (OS) shocks	614:657	shocks	652:657	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	6	19	theme	membrane	1170:1177	arg1	lipids					1179:1184	membrane lipids	1170:1184	membrane lipids	1170:1184	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	5	20	from	increase	972:979	arg1	proportion					988:997	the proportion	984:997	the proportion of phosphatidylethanolamines	984:1026	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	5	20	from	increase	972:979	arg1	level					946:950	the level	942:950	the level of trehalose	942:963	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	5	21	from	increase	930:937	arg1	proportion					988:997	the proportion	984:997	the proportion of phosphatidylethanolamines	984:1026	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	5	21	from	increase	930:937	arg1	level					946:950	the level	942:950	the level of trehalose	942:963	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	0	22	theme	heat	103:106	arg1	shocks					120:125	cold, heat and osmotic shocks	97:125	cold, heat and osmotic shocks	97:125	Membrane lipid and osmolyte readjustment in the alkaliphilic micromycete Sodiomyces tronii under cold, heat and osmotic shocks.
34816793	3	23	theme	HS	631:632	arg1	action					604:609	the action	600:609	the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii	600:716	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	7	24	dep	stressors	1545:1553	arg1	HS					1557:1558	HS	1557:1558	HS	1557:1558	Thus, the observed consistency of the composition of membrane lipids suggests that trehalose can participate in adaptation not only to extremely alkaline conditions, but also to other stressors - HS, CS and OS.
34816793	7	24	dep	stressors	1545:1553	arg1	stressors					1545:1553	other stressors	1539:1553	other stressors - HS, CS and OS	1539:1569	Thus, the observed consistency of the composition of membrane lipids suggests that trehalose can participate in adaptation not only to extremely alkaline conditions, but also to other stressors - HS, CS and OS.
34816793	7	24	dep	stressors	1545:1553	arg1	OS					1568:1569	OS	1568:1569	OS	1568:1569	Thus, the observed consistency of the composition of membrane lipids suggests that trehalose can participate in adaptation not only to extremely alkaline conditions, but also to other stressors - HS, CS and OS.
34816793	7	24	dep	stressors	1545:1553	arg1	CS					1561:1562	CS	1561:1562	CS	1561:1562	Thus, the observed consistency of the composition of membrane lipids suggests that trehalose can participate in adaptation not only to extremely alkaline conditions, but also to other stressors - HS, CS and OS.
34816793	5	25	theme	HS	905:906	arg1	conditions					908:917	HS conditions	905:917	HS conditions	905:917	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	1	26	theme	first	158:162	arg1	time					164:167	the first time	154:167	the first time	154:167	Previously, we showed for the first time that alkaliphilic fungi, in contrast to alkalitolerant fungi, accumulated trehalose under extremely alkaline conditions, and we have proposed its key role in alkaliphilia.
34816793	6	27	theme	fungal	1296:1301	arg1	mycelium					1303:1310	the fungal mycelium	1292:1310	the fungal mycelium	1292:1310	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	0	28	from	readjustment	28:39	arg1	tronii					84:89	the alkaliphilic micromycete Sodiomyces tronii	44:89	the alkaliphilic micromycete Sodiomyces tronii	44:89	Membrane lipid and osmolyte readjustment in the alkaliphilic micromycete Sodiomyces tronii under cold, heat and osmotic shocks.
34816793	6	29	dep	polyols	1257:1263	arg1	mannitol					1279:1286	mannitol	1279:1286	mannitol	1279:1286	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	6	29	dep	polyols	1257:1263	arg1	arabitol					1266:1273	arabitol	1266:1273	arabitol	1266:1273	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	6	29	dep	polyols	1257:1263	arg1	polyols					1257:1263	polyols	1257:1263	polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS	1257:1358	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	4	30	theme	lipids	873:878	arg1	composition					826:836	the composition	822:836	the composition of osmolytes, membrane and storage lipids	822:878	During adaptation to CS, an increase in the degree of unsaturation of phospholipids was observed while the composition of osmolytes, membrane and storage lipids remained the same.
34816793	4	31	from	increase	747:754	arg1	degree					763:768	the degree	759:768	the degree of unsaturation of phospholipids	759:801	During adaptation to CS, an increase in the degree of unsaturation of phospholipids was observed while the composition of osmolytes, membrane and storage lipids remained the same.
34816793	2	32	theme	high	357:360	arg1	levels					362:367	high levels	357:367	high levels of trehalose in the mycelium of alkaliphiles	357:412	We propose that high levels of trehalose in the mycelium of alkaliphiles may promote adaptation not only to alkaline conditions, but also to other stressors.
34816793	0	33	theme	Membrane	0:7	arg1	lipid					9:13	Membrane lipid	0:13	Membrane lipid	0:13	Membrane lipid and osmolyte readjustment in the alkaliphilic micromycete Sodiomyces tronii under cold, heat and osmotic shocks.
34816793	5	34	from	decrease	1070:1077	arg1	proportion					1086:1095	the proportion	1082:1095	the proportion of phosphatidic acids	1082:1117	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	5	35	theme	trehalose	955:963	arg1	level					946:950	the level	942:950	the level of trehalose	942:963	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	0	36	theme	osmolyte	19:26	arg1	readjustment					28:39	osmolyte readjustment	19:39	osmolyte readjustment	19:39	Membrane lipid and osmolyte readjustment in the alkaliphilic micromycete Sodiomyces tronii under cold, heat and osmotic shocks.
34816793	1	37	theme	alkaline	269:276	arg1	conditions					278:287	extremely alkaline conditions	259:287	extremely alkaline conditions	259:287	Previously, we showed for the first time that alkaliphilic fungi, in contrast to alkalitolerant fungi, accumulated trehalose under extremely alkaline conditions, and we have proposed its key role in alkaliphilia.
34816793	6	38	from	polyols	1257:1263	arg1	mycelium					1303:1310	the fungal mycelium	1292:1310	the fungal mycelium	1292:1310	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	5	39	theme	twofold	922:928	arg1	increase					930:937	a twofold increase	920:937	a twofold increase in the level of trehalose	920:963	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	1	40	theme	alkaliphilic	174:185	arg1	fungi					187:191	alkaliphilic fungi	174:191	alkaliphilic fungi	174:191	Previously, we showed for the first time that alkaliphilic fungi, in contrast to alkalitolerant fungi, accumulated trehalose under extremely alkaline conditions, and we have proposed its key role in alkaliphilia.
34816793	5	41	theme	phosphatidylethanolamines	1002:1026	arg1	proportion					988:997	the proportion	984:997	the proportion of phosphatidylethanolamines	984:1026	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	0	42	theme	osmotic	112:118	arg1	shocks					120:125	cold, heat and osmotic shocks	97:125	cold, heat and osmotic shocks	97:125	Membrane lipid and osmolyte readjustment in the alkaliphilic micromycete Sodiomyces tronii under cold, heat and osmotic shocks.
34816793	7	43	theme	observed	1371:1378	arg1	consistency					1380:1390	the observed consistency	1367:1390	the observed consistency of the composition of membrane lipids	1367:1428	Thus, the observed consistency of the composition of membrane lipids suggests that trehalose can participate in adaptation not only to extremely alkaline conditions, but also to other stressors - HS, CS and OS.
34816793	8	44	theme	stressors	1671:1679	arg1	action					1653:1658	the action	1649:1658	the action	1649:1658	Taken together, the data obtained indicate the adaptability of the fungus to the action of various stressors, which can point to polyextremotolerance.
34816793	1	45	from	role	319:322	arg1	alkaliphilia					327:338	alkaliphilia	327:338	alkaliphilia	327:338	Previously, we showed for the first time that alkaliphilic fungi, in contrast to alkalitolerant fungi, accumulated trehalose under extremely alkaline conditions, and we have proposed its key role in alkaliphilia.
34816793	3	46	theme	OS	648:649	arg1	shocks					652:657	cold (CS), heat (HS) and osmotic (OS) shocks	614:657	shocks	652:657	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	4	47	theme	osmolytes	841:849	arg1	composition					826:836	the composition	822:836	the composition of osmolytes, membrane and storage lipids	822:878	During adaptation to CS, an increase in the degree of unsaturation of phospholipids was observed while the composition of osmolytes, membrane and storage lipids remained the same.
34816793	1	48	dep	fungi	224:228	arg1	contrast					197:204	contrast	197:204	contrast	197:204	Previously, we showed for the first time that alkaliphilic fungi, in contrast to alkalitolerant fungi, accumulated trehalose under extremely alkaline conditions, and we have proposed its key role in alkaliphilia.
34816793	3	49	theme	osmolytes	551:559	arg1	composition					536:546	the composition	532:546	the composition of osmolytes	532:559	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	7	50	theme	alkaline	1506:1513	arg1	conditions					1515:1524	extremely alkaline conditions	1496:1524	extremely alkaline conditions	1496:1524	Thus, the observed consistency of the composition of membrane lipids suggests that trehalose can participate in adaptation not only to extremely alkaline conditions, but also to other stressors - HS, CS and OS.
34816793	6	51	theme	polyols	1257:1263	arg1	level					1248:1252	the level	1244:1252	the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS	1244:1358	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	3	52	theme	obligate	666:673	arg1	tronii					711:716	the obligate alkaliphilic micromycete Sodiomyces tronii	662:716	the obligate alkaliphilic micromycete Sodiomyces tronii	662:716	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	5	53	from	proportion	1086:1095	arg1	background					1054:1063	the background	1050:1063	the background of a decrease in the proportion of phosphatidic acids	1050:1117	Under HS conditions, a twofold increase in the level of trehalose and an increase in the proportion of phosphatidylethanolamines were observed against the background of a decrease in the proportion of phosphatidic acids.
34816793	2	54	theme	alkaliphiles	401:412	arg1	mycelium					389:396	the mycelium	385:396	the mycelium of alkaliphiles	385:412	We propose that high levels of trehalose in the mycelium of alkaliphiles may promote adaptation not only to alkaline conditions, but also to other stressors.
34816793	2	55	theme	trehalose	372:380	arg1	levels					362:367	high levels	357:367	high levels of trehalose in the mycelium of alkaliphiles	357:412	We propose that high levels of trehalose in the mycelium of alkaliphiles may promote adaptation not only to alkaline conditions, but also to other stressors.
34816793	0	56	theme	alkaliphilic	48:59	arg1	tronii					84:89	the alkaliphilic micromycete Sodiomyces tronii	44:89	the alkaliphilic micromycete Sodiomyces tronii	44:89	Membrane lipid and osmolyte readjustment in the alkaliphilic micromycete Sodiomyces tronii under cold, heat and osmotic shocks.
34816793	3	57	theme	alkaliphilic	675:686	arg1	tronii					711:716	the obligate alkaliphilic micromycete Sodiomyces tronii	662:716	the obligate alkaliphilic micromycete Sodiomyces tronii	662:716	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	4	58	theme	phospholipids	789:801	arg1	unsaturation					773:784	unsaturation	773:784	unsaturation of phospholipids	773:801	During adaptation to CS, an increase in the degree of unsaturation of phospholipids was observed while the composition of osmolytes, membrane and storage lipids remained the same.
34816793	3	59	theme	shocks	652:657	arg1	action					604:609	the action	600:609	the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii	600:716	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	7	60	theme	other	1539:1543	arg1	HS					1557:1558	HS	1557:1558	HS	1557:1558	Thus, the observed consistency of the composition of membrane lipids suggests that trehalose can participate in adaptation not only to extremely alkaline conditions, but also to other stressors - HS, CS and OS.
34816793	7	60	theme	other	1539:1543	arg1	stressors					1545:1553	other stressors	1539:1553	other stressors - HS, CS and OS	1539:1569	Thus, the observed consistency of the composition of membrane lipids suggests that trehalose can participate in adaptation not only to extremely alkaline conditions, but also to other stressors - HS, CS and OS.
34816793	7	60	theme	other	1539:1543	arg1	OS					1568:1569	OS	1568:1569	OS	1568:1569	Thus, the observed consistency of the composition of membrane lipids suggests that trehalose can participate in adaptation not only to extremely alkaline conditions, but also to other stressors - HS, CS and OS.
34816793	7	60	theme	other	1539:1543	arg1	CS					1561:1562	CS	1561:1562	CS	1561:1562	Thus, the observed consistency of the composition of membrane lipids suggests that trehalose can participate in adaptation not only to extremely alkaline conditions, but also to other stressors - HS, CS and OS.
34816793	4	61	theme	storage	865:871	arg1	lipids					873:878	storage lipids	865:878	storage lipids	865:878	During adaptation to CS, an increase in the degree of unsaturation of phospholipids was observed while the composition of osmolytes, membrane and storage lipids remained the same.
34816793	6	62	from	decrease	1144:1151	arg1	amount					1160:1165	the amount	1156:1165	the amount	1156:1165	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	6	62	from	decrease	1144:1151	arg1	lipids					1179:1184	membrane lipids	1170:1184	membrane lipids	1170:1184	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	6	62	from	decrease	1144:1151	arg1	level					1248:1252	the level	1244:1252	the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS	1244:1358	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	3	63	from	action	604:609	arg1	tronii					711:716	the obligate alkaliphilic micromycete Sodiomyces tronii	662:716	the obligate alkaliphilic micromycete Sodiomyces tronii	662:716	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	3	64	theme	storage	566:572	arg1	lipids					587:592	storage and membrane lipids	566:592	lipids	587:592	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	2	65	from	levels	362:367	arg1	mycelium					389:396	the mycelium	385:396	the mycelium of alkaliphiles	385:412	We propose that high levels of trehalose in the mycelium of alkaliphiles may promote adaptation not only to alkaline conditions, but also to other stressors.
34816793	3	66	from	changes	521:527	arg1	composition					536:546	the composition	532:546	the composition of osmolytes	532:559	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	6	67	theme	lipids	1179:1184	arg1	amount					1160:1165	the amount	1156:1165	the amount	1156:1165	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	6	67	theme	lipids	1179:1184	arg1	lipids					1179:1184	membrane lipids	1170:1184	membrane lipids	1170:1184	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	3	68	theme	membrane	578:585	arg1	lipids					587:592	storage and membrane lipids	566:592	lipids	587:592	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	7	69	theme	membrane	1414:1421	arg1	lipids					1423:1428	membrane lipids	1414:1428	membrane lipids	1414:1428	Thus, the observed consistency of the composition of membrane lipids suggests that trehalose can participate in adaptation not only to extremely alkaline conditions, but also to other stressors - HS, CS and OS.
34816793	0	70	theme	Sodiomyces	73:82	arg1	tronii					84:89	the alkaliphilic micromycete Sodiomyces tronii	44:89	the alkaliphilic micromycete Sodiomyces tronii	44:89	Membrane lipid and osmolyte readjustment in the alkaliphilic micromycete Sodiomyces tronii under cold, heat and osmotic shocks.
34816793	3	71	theme	cold	614:617	arg1	HS					631:632	cold (CS), heat (HS) and osmotic (OS) shocks	614:657	HS	631:632	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	4	72	dep	CS	740:741	arg1	adaptation					726:735	adaptation	726:735	adaptation	726:735	During adaptation to CS, an increase in the degree of unsaturation of phospholipids was observed while the composition of osmolytes, membrane and storage lipids remained the same.
34816793	3	73	theme	micromycete	688:698	arg1	tronii					711:716	the obligate alkaliphilic micromycete Sodiomyces tronii	662:716	the obligate alkaliphilic micromycete Sodiomyces tronii	662:716	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	1	74	theme	alkalitolerant	209:222	arg1	fungi					224:228	alkalitolerant fungi	209:228	alkalitolerant fungi	209:228	Previously, we showed for the first time that alkaliphilic fungi, in contrast to alkalitolerant fungi, accumulated trehalose under extremely alkaline conditions, and we have proposed its key role in alkaliphilia.
34816793	0	75	theme	micromycete	61:71	arg1	tronii					84:89	the alkaliphilic micromycete Sodiomyces tronii	44:89	the alkaliphilic micromycete Sodiomyces tronii	44:89	Membrane lipid and osmolyte readjustment in the alkaliphilic micromycete Sodiomyces tronii under cold, heat and osmotic shocks.
34816793	6	76	from	level	1248:1252	arg1	mycelium					1303:1310	the fungal mycelium	1292:1310	the fungal mycelium	1292:1310	OS was accompanied by a decrease in the amount of membrane lipids, while their ratio remained unchanged, and an increase in the level of polyols (arabitol and mannitol) in the fungal mycelium, which suggests their role for adaptation to OS.
34816793	3	77	theme	Sodiomyces	700:709	arg1	tronii					711:716	the obligate alkaliphilic micromycete Sodiomyces tronii	662:716	the obligate alkaliphilic micromycete Sodiomyces tronii	662:716	Therefore, we studied changes in the composition of osmolytes, and storage and membrane lipids under the action of cold (CS), heat (HS) and osmotic (OS) shocks in the obligate alkaliphilic micromycete Sodiomyces tronii.
34816793	4	78	theme	membrane	852:859	arg1	composition					826:836	the composition	822:836	the composition of osmolytes, membrane and storage lipids	822:878	During adaptation to CS, an increase in the degree of unsaturation of phospholipids was observed while the composition of osmolytes, membrane and storage lipids remained the same.
34816793	2	79	theme	other	482:486	arg1	stressors					488:496	other stressors	482:496	other stressors	482:496	We propose that high levels of trehalose in the mycelium of alkaliphiles may promote adaptation not only to alkaline conditions, but also to other stressors.
32442574	3	0	theme	1 → 4,6	498:504	arg1	β-d-glucopyranose					514:530	(1 → 4,6)-linked β-d-glucopyranose	497:530	(1 → 4,6)-linked β-d-glucopyranose	497:530	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	7	1	theme	cough	878:882	arg1	effort					884:889	cough effort	878:889	cough effort	878:889	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	9	2	theme	COX-2	1354:1358	arg1	induction					1341:1349	induction	1341:1349	induction of COX-2 and iNOS expression	1341:1378	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	0	3	theme	Nostoc	98:103	arg1	sp					105:106	cyanobacterium Nostoc sp	83:106	cyanobacterium Nostoc sp	83:106	Structural characteristics and biological effects of exopolysaccharide produced by cyanobacterium Nostoc sp.
32442574	3	4	theme	NMR	279:281	arg1	analyses					283:290	Chemical and NMR analyses	266:290	analyses	283:290	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	7	5	theme	significant	854:864	arg1	decrease					866:873	a significant decrease	852:873	a significant decrease in cough effort	852:889	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	5	6	from	amount	711:716	arg1	present					694:700	present	694:700	present	694:700	β-d-Glucuronic acid was present in lower amount.
32442574	7	7	from	pigs	840:843	arg1	doses					797:801	Different doses	787:801	Different doses of orally administered EPS in guinea pigs	787:843	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	7	8	from	EPS	826:828	arg1	pigs					840:843	guinea pigs	833:843	guinea pigs	833:843	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	3	9	link	-linked	342:348	arg1	α-l-arabinopyranose					350:368	(1 → 4)-linked α-l-arabinopyranose	335:368	(1 → 4)-linked α-l-arabinopyranose	335:368	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	9	link	-linked	342:348	arg1	monomers					318:325	four dominant sugar monomers	298:325	four dominant sugar monomers	298:325	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	5	10	from	present	694:700	arg1	amount					711:716	lower amount	705:716	lower amount	705:716	β-d-Glucuronic acid was present in lower amount.
32442574	9	11	theme	immune	1455:1460	arg1	response					1462:1469	an early innate immune response	1439:1469	an early innate immune response	1439:1469	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	7	12	from	decrease	866:873	arg1	reactivity					916:925	airway reactivity	909:925	airway reactivity	909:925	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	7	12	from	decrease	866:873	arg1	effort					884:889	cough effort	878:889	cough effort	878:889	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	8	13	theme	higher	982:987	arg1	doses					989:993	higher doses	982:993	higher doses of EPS	982:1000	The antitussive efficacy and bronchodilator effect of higher doses of EPS were found to be similar to that of the antitussive drug codeine and the antiasthmatic salbutamol.
32442574	3	14	theme	branch	544:549	arg1	point					551:555	the only branch point	535:555	the only branch point	535:555	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	9	15	theme	expression	1369:1378	arg1	induction					1341:1349	induction	1341:1349	induction of COX-2 and iNOS expression	1341:1378	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	3	16	theme	-linked	342:348	arg1	α-l-arabinopyranose					350:368	(1 → 4)-linked α-l-arabinopyranose	335:368	(1 → 4)-linked α-l-arabinopyranose	335:368	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	16	theme	-linked	342:348	arg1	monomers					318:325	four dominant sugar monomers	298:325	four dominant sugar monomers	298:325	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	17	theme	Chemical	266:273	arg1	analyses					283:290	Chemical and NMR analyses	266:290	analyses	283:290	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	18	theme	lactyl	478:483	arg1	group					485:489	a lactyl group	476:489	a lactyl group	476:489	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	5	19	attach	present	694:700	arg1	amount					711:716	lower amount	705:716	lower amount	705:716	β-d-Glucuronic acid was present in lower amount.
32442574	5	19	attach	present	694:700	arg2	acid					685:688	β-d-Glucuronic acid	670:688	β-d-Glucuronic acid	670:688	β-d-Glucuronic acid was present in lower amount.
32442574	3	20	theme	different	449:457	arg1	acids					466:470	two different uronic acids	445:470	two different uronic acids	445:470	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	9	21	theme	macrophage	1177:1186	arg1	cells					1188:1192	the macrophage cells	1173:1192	the macrophage cells	1173:1192	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	22	theme	early	1442:1446	arg1	response					1462:1469	an early innate immune response	1439:1469	an early innate immune response	1439:1469	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	7	23	theme	guinea	833:838	arg1	pigs					840:843	guinea pigs	833:843	guinea pigs	833:843	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	3	24	theme	uronic	459:464	arg1	acids					466:470	two different uronic acids	445:470	two different uronic acids	445:470	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	7	25	theme	Different	787:795	arg1	doses					797:801	Different doses	787:801	Different doses of orally administered EPS in guinea pigs	787:843	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	7	26	from	doses	797:801	arg1	pigs					840:843	guinea pigs	833:843	guinea pigs	833:843	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	8	27	theme	doses	989:993	arg1	efficacy					944:951	antitussive efficacy	932:951	antitussive efficacy	932:951	The antitussive efficacy and bronchodilator effect of higher doses of EPS were found to be similar to that of the antitussive drug codeine and the antiasthmatic salbutamol.
32442574	8	27	theme	doses	989:993	arg1	effect					972:977	bronchodilator effect	957:977	bronchodilator effect	957:977	The antitussive efficacy and bronchodilator effect of higher doses of EPS were found to be similar to that of the antitussive drug codeine and the antiasthmatic salbutamol.
32442574	9	28	theme	new	1502:1504	arg1	biopolymer					1416:1425	this biopolymer	1411:1425	this biopolymer	1411:1425	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	28	theme	new	1502:1504	arg1	modulator					1513:1521	a new immune modulator	1500:1521	a new immune modulator	1500:1521	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	5	29	theme	β-d-Glucuronic	670:683	arg1	acid					685:688	β-d-Glucuronic acid	670:688	β-d-Glucuronic acid	670:688	β-d-Glucuronic acid was present in lower amount.
32442574	5	30	theme	lower	705:709	arg1	amount					711:716	lower amount	705:716	lower amount	705:716	β-d-Glucuronic acid was present in lower amount.
32442574	0	31	theme	Structural	0:9	arg1	characteristics					11:25	Structural characteristics	0:25	Structural characteristics	0:25	Structural characteristics and biological effects of exopolysaccharide produced by cyanobacterium Nostoc sp.
32442574	3	32	dep	β-d-mannopyranose	426:442	arg1	1 → 3					412:416	1 → 3	412:416	1 → 3	412:416	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	9	33	used	used	1492:1495	arg2	modulator					1513:1521	a new immune modulator	1500:1521	a new immune modulator	1500:1521	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	33	used	used	1492:1495	arg2	biopolymer					1416:1425	this biopolymer	1411:1425	this biopolymer	1411:1425	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	1	34	theme	Complex	109:115	arg1	structure					117:125	Complex structure	109:125	Complex structure of cyanobacterium Nostoc sp	109:153	Complex structure of cyanobacterium Nostoc sp.
32442574	7	35	theme	EPS	826:828	arg1	doses					797:801	Different doses	787:801	Different doses of orally administered EPS in guinea pigs	787:843	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	0	36	theme	biological	31:40	arg1	effects					42:48	biological effects	31:48	biological effects	31:48	Structural characteristics and biological effects of exopolysaccharide produced by cyanobacterium Nostoc sp.
32442574	3	37	with	acids	466:470	arg1	β-d-glucopyranose					514:530	(1 → 4,6)-linked β-d-glucopyranose	497:530	(1 → 4,6)-linked β-d-glucopyranose	497:530	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	7	38	theme	airway	909:914	arg1	reactivity					916:925	airway reactivity	909:925	airway reactivity	909:925	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	9	39	from	cytotoxicity	1121:1132	arg1	cells					1151:1155	the RAW 264.7 cells	1137:1155	the RAW 264.7 cells	1137:1155	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	3	40	theme	complex	567:573	arg1	structure					575:583	a complex structure	565:583	a complex structure of this polymer	565:599	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	8	41	theme	antitussive	1042:1052	arg1	drug					1054:1057	the antitussive drug codeine and the antiasthmatic salbutamol	1038:1098	drug	1054:1057	The antitussive efficacy and bronchodilator effect of higher doses of EPS were found to be similar to that of the antitussive drug codeine and the antiasthmatic salbutamol.
32442574	2	42	theme	molecular	195:203	arg1	214 × 103 g/mol					212:226	apparent molecular weight 214 × 103 g/mol	186:226	apparent molecular weight 214 × 103 g/mol	186:226	exopolysaccharide (EPS), with apparent molecular weight 214 × 103 g/mol, can be deduced from its composition.
32442574	7	43	from	decrease	897:904	arg1	reactivity					916:925	airway reactivity	909:925	airway reactivity	909:925	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	7	43	from	decrease	897:904	arg1	effort					884:889	cough effort	878:889	cough effort	878:889	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	2	44	with	exopolysaccharide	156:172	arg1	214 × 103 g/mol					212:226	apparent molecular weight 214 × 103 g/mol	186:226	apparent molecular weight 214 × 103 g/mol	186:226	exopolysaccharide (EPS), with apparent molecular weight 214 × 103 g/mol, can be deduced from its composition.
32442574	3	45	theme	-linked	418:424	arg1	monomers					318:325	four dominant sugar monomers	298:325	four dominant sugar monomers	298:325	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	45	theme	-linked	418:424	arg1	β-d-mannopyranose					426:442	(1 → 3)-linked β-d-mannopyranose	411:442	(1 → 3)-linked β-d-mannopyranose	411:442	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	5	46	located	present	694:700	arg2	acid					685:688	β-d-Glucuronic acid	670:688	β-d-Glucuronic acid	670:688	β-d-Glucuronic acid was present in lower amount.
32442574	5	46	located	present	694:700	arg1	amount					711:716	lower amount	705:716	lower amount	705:716	β-d-Glucuronic acid was present in lower amount.
32442574	3	47	link	-linked	506:512	arg1	β-d-glucopyranose					514:530	(1 → 4,6)-linked β-d-glucopyranose	497:530	(1 → 4,6)-linked β-d-glucopyranose	497:530	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	2	48	theme	apparent	186:193	arg1	214 × 103 g/mol					212:226	apparent molecular weight 214 × 103 g/mol	186:226	apparent molecular weight 214 × 103 g/mol	186:226	exopolysaccharide (EPS), with apparent molecular weight 214 × 103 g/mol, can be deduced from its composition.
32442574	7	49	theme	administered	813:824	arg1	EPS					826:828	orally administered EPS	806:828	orally administered EPS in guinea pigs	806:843	Different doses of orally administered EPS in guinea pigs evoked a significant decrease in cough effort and a decrease in airway reactivity.
32442574	9	50	theme	nitric	1319:1324	arg1	oxide					1326:1330	nitric oxide	1319:1330	nitric oxide (NO)	1319:1335	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	50	theme	nitric	1319:1324	arg1	NO					1333:1334	NO	1333:1334	NO	1333:1334	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	51	theme	tumor	1232:1236	arg1	TNF-α					1257:1261	TNF-α	1257:1261	TNF-α	1257:1261	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	51	theme	tumor	1232:1236	arg1	cytokines					1222:1230	pro-inflammatory cytokines	1205:1230	pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)	1205:1287	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	51	theme	tumor	1232:1236	arg1	factor-α					1247:1254	tumor necrosis factor-α	1232:1254	tumor necrosis factor-α (TNF-α)	1232:1262	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	3	52	theme	polymer	593:599	arg1	structure					575:583	a complex structure	565:583	a complex structure of this polymer	565:599	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	8	53	dep	drug	1054:1057	arg1	codeine					1059:1065	codeine	1059:1065	codeine	1059:1065	The antitussive efficacy and bronchodilator effect of higher doses of EPS were found to be similar to that of the antitussive drug codeine and the antiasthmatic salbutamol.
32442574	8	54	theme	antiasthmatic	1075:1087	arg1	salbutamol					1089:1098	the antiasthmatic salbutamol	1071:1098	the antiasthmatic salbutamol	1071:1098	The antitussive efficacy and bronchodilator effect of higher doses of EPS were found to be similar to that of the antitussive drug codeine and the antiasthmatic salbutamol.
32442574	9	55	theme	necrosis	1238:1245	arg1	TNF-α					1257:1261	TNF-α	1257:1261	TNF-α	1257:1261	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	55	theme	necrosis	1238:1245	arg1	cytokines					1222:1230	pro-inflammatory cytokines	1205:1230	pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)	1205:1287	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	55	theme	necrosis	1238:1245	arg1	factor-α					1247:1254	tumor necrosis factor-α	1232:1254	tumor necrosis factor-α (TNF-α)	1232:1262	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	3	56	link	-linked	418:424	arg1	monomers					318:325	four dominant sugar monomers	298:325	four dominant sugar monomers	298:325	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	56	link	-linked	418:424	arg1	β-d-mannopyranose					426:442	(1 → 3)-linked β-d-mannopyranose	411:442	(1 → 3)-linked β-d-mannopyranose	411:442	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	9	57	theme	significant	1109:1119	arg1	cytotoxicity					1121:1132	significant cytotoxicity	1109:1132	significant cytotoxicity on the RAW 264.7 cells	1109:1155	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	1	58	theme	cyanobacterium	130:143	arg1	sp					152:153	cyanobacterium Nostoc sp	130:153	cyanobacterium Nostoc sp	130:153	Complex structure of cyanobacterium Nostoc sp.
32442574	0	59	theme	exopolysaccharide	53:69	arg1	characteristics					11:25	Structural characteristics	0:25	Structural characteristics	0:25	Structural characteristics and biological effects of exopolysaccharide produced by cyanobacterium Nostoc sp.
32442574	0	59	theme	exopolysaccharide	53:69	arg1	effects					42:48	biological effects	31:48	biological effects	31:48	Structural characteristics and biological effects of exopolysaccharide produced by cyanobacterium Nostoc sp.
32442574	3	60	dep	α-l-arabinopyranose	350:368	arg1	1 → 4					336:340	1 → 4	336:340	1 → 4	336:340	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	1	61	theme	Nostoc	145:150	arg1	sp					152:153	cyanobacterium Nostoc sp	130:153	cyanobacterium Nostoc sp	130:153	Complex structure of cyanobacterium Nostoc sp.
32442574	8	62	theme	EPS	998:1000	arg1	doses					989:993	higher doses	982:993	higher doses of EPS	982:1000	The antitussive efficacy and bronchodilator effect of higher doses of EPS were found to be similar to that of the antitussive drug codeine and the antiasthmatic salbutamol.
32442574	3	63	theme	dominant	303:310	arg1	α-l-arabinopyranose					350:368	(1 → 4)-linked α-l-arabinopyranose	335:368	(1 → 4)-linked α-l-arabinopyranose	335:368	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	63	theme	dominant	303:310	arg1	β-d-mannopyranose					426:442	(1 → 3)-linked β-d-mannopyranose	411:442	(1 → 3)-linked β-d-mannopyranose	411:442	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	63	theme	dominant	303:310	arg1	monomers					318:325	four dominant sugar monomers	298:325	four dominant sugar monomers	298:325	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	63	theme	dominant	303:310	arg1	β-d-xylopyranose					390:405	β-d-xylopyranose	390:405	β-d-xylopyranose	390:405	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	63	theme	dominant	303:310	arg1	β-d-glucopyranose					371:387	β-d-glucopyranose	371:387	β-d-glucopyranose	371:387	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	8	64	theme	bronchodilator	957:970	arg1	effect					972:977	bronchodilator effect	957:977	bronchodilator effect	957:977	The antitussive efficacy and bronchodilator effect of higher doses of EPS were found to be similar to that of the antitussive drug codeine and the antiasthmatic salbutamol.
32442574	1	65	theme	sp	152:153	arg1	structure					117:125	Complex structure	109:125	Complex structure of cyanobacterium Nostoc sp	109:153	Complex structure of cyanobacterium Nostoc sp.
32442574	8	66	dep	efficacy	944:951	arg1	The					928:930	The	928:930	The	928:930	The antitussive efficacy and bronchodilator effect of higher doses of EPS were found to be similar to that of the antitussive drug codeine and the antiasthmatic salbutamol.
32442574	3	67	theme	sugar	312:316	arg1	α-l-arabinopyranose					350:368	(1 → 4)-linked α-l-arabinopyranose	335:368	(1 → 4)-linked α-l-arabinopyranose	335:368	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	67	theme	sugar	312:316	arg1	β-d-mannopyranose					426:442	(1 → 3)-linked β-d-mannopyranose	411:442	(1 → 3)-linked β-d-mannopyranose	411:442	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	67	theme	sugar	312:316	arg1	monomers					318:325	four dominant sugar monomers	298:325	four dominant sugar monomers	298:325	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	67	theme	sugar	312:316	arg1	β-d-xylopyranose					390:405	β-d-xylopyranose	390:405	β-d-xylopyranose	390:405	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	67	theme	sugar	312:316	arg1	β-d-glucopyranose					371:387	β-d-glucopyranose	371:387	β-d-glucopyranose	371:387	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	3	68	theme	only	539:542	arg1	point					551:555	the only branch point	535:555	the only branch point	535:555	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	8	69	theme	antitussive	932:942	arg1	efficacy					944:951	antitussive efficacy	932:951	antitussive efficacy	932:951	The antitussive efficacy and bronchodilator effect of higher doses of EPS were found to be similar to that of the antitussive drug codeine and the antiasthmatic salbutamol.
32442574	3	70	with	group	485:489	arg1	β-d-glucopyranose					514:530	(1 → 4,6)-linked β-d-glucopyranose	497:530	(1 → 4,6)-linked β-d-glucopyranose	497:530	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	9	71	theme	innate	1448:1453	arg1	response					1462:1469	an early innate immune response	1439:1469	an early innate immune response	1439:1469	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	0	72	theme	cyanobacterium	83:96	arg1	sp					105:106	cyanobacterium Nostoc sp	83:106	cyanobacterium Nostoc sp	83:106	Structural characteristics and biological effects of exopolysaccharide produced by cyanobacterium Nostoc sp.
32442574	2	73	theme	weight	205:210	arg1	214 × 103 g/mol					212:226	apparent molecular weight 214 × 103 g/mol	186:226	apparent molecular weight 214 × 103 g/mol	186:226	exopolysaccharide (EPS), with apparent molecular weight 214 × 103 g/mol, can be deduced from its composition.
32442574	9	74	theme	pro-inflammatory	1205:1220	arg1	cytokines					1222:1230	pro-inflammatory cytokines	1205:1230	pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)	1205:1287	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	74	theme	pro-inflammatory	1205:1220	arg1	factor-α					1247:1254	tumor necrosis factor-α	1232:1254	tumor necrosis factor-α (TNF-α)	1232:1262	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	74	theme	pro-inflammatory	1205:1220	arg1	interleukin-6					1268:1280	interleukin-6	1268:1280	interleukin-6 (IL-6)	1268:1287	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	75	theme	RAW	1141:1143	arg1	cells					1151:1155	the RAW 264.7 cells	1137:1155	the RAW 264.7 cells	1137:1155	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	3	76	theme	-linked	506:512	arg1	β-d-glucopyranose					514:530	(1 → 4,6)-linked β-d-glucopyranose	497:530	(1 → 4,6)-linked β-d-glucopyranose	497:530	Chemical and NMR analyses found four dominant sugar monomers, namely (1 → 4)-linked α-l-arabinopyranose, β-d-glucopyranose, β-d-xylopyranose and (1 → 3)-linked β-d-mannopyranose, two different uronic acids and a lactyl group, with (1 → 4,6)-linked β-d-glucopyranose as the only branch point suggest a complex structure of this polymer.
32442574	9	77	theme	immune	1506:1511	arg1	biopolymer					1416:1425	this biopolymer	1411:1425	this biopolymer	1411:1425	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	77	theme	immune	1506:1511	arg1	modulator					1513:1521	a new immune modulator	1500:1521	a new immune modulator	1500:1521	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	4	78	theme	uronic	615:620	arg1	α-linked					630:637	α-linked	630:637	α-linked	630:637	The dominant uronic acid is α-linked, but it remained unidentified.
32442574	4	78	theme	uronic	615:620	arg1	acid					622:625	The dominant uronic acid	602:625	The dominant uronic acid	602:625	The dominant uronic acid is α-linked, but it remained unidentified.
32442574	9	79	theme	iNOS	1364:1367	arg1	expression					1369:1378	iNOS expression	1364:1378	iNOS expression	1364:1378	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	80	dep	cytokines	1222:1230	arg1	IL-6					1283:1286	IL-6	1283:1286	IL-6	1283:1286	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	80	dep	cytokines	1222:1230	arg1	TNF-α					1257:1261	TNF-α	1257:1261	TNF-α	1257:1261	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	80	dep	cytokines	1222:1230	arg1	interleukin-6					1268:1280	interleukin-6	1268:1280	interleukin-6 (IL-6)	1268:1287	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	80	dep	cytokines	1222:1230	arg1	factor-α					1247:1254	tumor necrosis factor-α	1232:1254	tumor necrosis factor-α (TNF-α)	1232:1262	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	9	80	dep	cytokines	1222:1230	arg1	cytokines					1222:1230	pro-inflammatory cytokines	1205:1230	pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)	1205:1287	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.
32442574	4	81	theme	dominant	606:613	arg1	α-linked					630:637	α-linked	630:637	α-linked	630:637	The dominant uronic acid is α-linked, but it remained unidentified.
32442574	4	81	theme	dominant	606:613	arg1	acid					622:625	The dominant uronic acid	602:625	The dominant uronic acid	602:625	The dominant uronic acid is α-linked, but it remained unidentified.
32314510	4	0	theme	chelation	544:552	arg1	interactions					554:565	chelation interactions	544:565	chelation interactions	544:565	The composite hydrogels were in situ formed by electrostatic interactions, chelation interactions, and covalent bonds between carboxylated chitosan and DR under ultraviolet assisted without small photosensitizer.
32314510	8	1	theme	trace	1039:1043	arg1	zinc					1045:1048	trace zinc	1039:1048	trace zinc	1039:1048	The present study demonstrates this composite DR-CCH with trace zinc has potential for accelerated wound healing.
32314510	6	2	dep	showed	828:833	arg1	kill					864:867	kill	864:867	kill Escherichia coli and Staphylococcus aureus	864:910	The antibacterial assays showed the DR-CCH could inhibit and kill Escherichia coli and Staphylococcus aureus.
32314510	6	2	dep	showed	828:833	arg1	inhibit					852:858	inhibit	852:858	inhibit	852:858	The antibacterial assays showed the DR-CCH could inhibit and kill Escherichia coli and Staphylococcus aureus.
32314510	5	3	from	concentrations	762:775	arg1	buffers					794:800	physiological buffers	780:800	physiological buffers	780:800	The resultant hydrogels (noted as DR-CCH) showed good stability at different DR concentrations in physiological buffers.
32314510	0	4	theme	wound	113:117	arg1	healing					119:125	improved wound healing	104:125	improved wound healing	104:125	Chitosan composite hydrogels cross-linked by multifunctional diazo resin as antibacterial dressings for improved wound healing.
32314510	7	5	theme	wound	958:962	arg1	healing					964:970	wound healing	958:970	wound healing	958:970	What is more, our hydrogels could accelerate wound healing in vivo.
32314510	4	6	theme	small	659:663	arg1	photosensitizer					665:679	small photosensitizer	659:679	small photosensitizer	659:679	The composite hydrogels were in situ formed by electrostatic interactions, chelation interactions, and covalent bonds between carboxylated chitosan and DR under ultraviolet assisted without small photosensitizer.
32314510	0	7	theme	improved	104:111	arg1	healing					119:125	improved wound healing	104:125	improved wound healing	104:125	Chitosan composite hydrogels cross-linked by multifunctional diazo resin as antibacterial dressings for improved wound healing.
32314510	4	8	theme	electrostatic	516:528	arg1	interactions					530:541	electrostatic interactions	516:541	electrostatic interactions	516:541	The composite hydrogels were in situ formed by electrostatic interactions, chelation interactions, and covalent bonds between carboxylated chitosan and DR under ultraviolet assisted without small photosensitizer.
32314510	5	9	theme	good	731:734	arg1	stability					736:744	good stability	731:744	good stability	731:744	The resultant hydrogels (noted as DR-CCH) showed good stability at different DR concentrations in physiological buffers.
32314510	8	10	theme	accelerated	1068:1078	arg1	healing					1086:1092	accelerated wound healing	1068:1092	accelerated wound healing	1068:1092	The present study demonstrates this composite DR-CCH with trace zinc has potential for accelerated wound healing.
32314510	3	11	theme	diazo	397:401	arg1	resin					403:407	multifunctional diazo resin	381:407	multifunctional diazo resin (DR)	381:412	Herein, we developed chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing.
32314510	3	11	theme	diazo	397:401	arg1	DR					410:411	DR	410:411	DR	410:411	Herein, we developed chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing.
32314510	5	12	theme	resultant	686:694	arg1	hydrogels					696:704	The resultant hydrogels	682:704	The resultant hydrogels (noted as DR-CCH)	682:722	The resultant hydrogels (noted as DR-CCH) showed good stability at different DR concentrations in physiological buffers.
32314510	8	13	contain	has	1050:1052	arg2	potential					1054:1062	potential	1054:1062	potential for accelerated wound healing	1054:1092	The present study demonstrates this composite DR-CCH with trace zinc has potential for accelerated wound healing.
32314510	8	13	contain	has	1050:1052	arg1	zinc					1045:1048	trace zinc	1039:1048	trace zinc	1039:1048	The present study demonstrates this composite DR-CCH with trace zinc has potential for accelerated wound healing.
32314510	0	14	theme	diazo	61:65	arg1	resin					67:71	multifunctional diazo resin	45:71	multifunctional diazo resin	45:71	Chitosan composite hydrogels cross-linked by multifunctional diazo resin as antibacterial dressings for improved wound healing.
32314510	0	15	theme	multifunctional	45:59	arg1	resin					67:71	multifunctional diazo resin	45:71	multifunctional diazo resin	45:71	Chitosan composite hydrogels cross-linked by multifunctional diazo resin as antibacterial dressings for improved wound healing.
32314510	1	16	theme	pathogen	179:186	arg1	infections					188:197	pathogen infections	179:197	pathogen infections	179:197	Skin lesions and injuries can increase the risk of pathogen infections.
32314510	3	17	theme	antibacterial	417:429	arg1	hydrogels					355:363	chitosan composite hydrogels	336:363	chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR)	336:412	Herein, we developed chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing.
32314510	3	17	theme	antibacterial	417:429	arg1	dressings					431:439	antibacterial dressings	417:439	antibacterial dressings for improved wound healing	417:466	Herein, we developed chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing.
32314510	8	18	theme	wound	1080:1084	arg1	healing					1086:1092	accelerated wound healing	1068:1092	accelerated wound healing	1068:1092	The present study demonstrates this composite DR-CCH with trace zinc has potential for accelerated wound healing.
32314510	1	19	theme	infections	188:197	arg1	risk					171:174	the risk	167:174	the risk of pathogen infections	167:197	Skin lesions and injuries can increase the risk of pathogen infections.
32314510	0	20	theme	Chitosan	0:7	arg1	composite					9:17	Chitosan composite	0:17	Chitosan composite	0:17	Chitosan composite hydrogels cross-linked by multifunctional diazo resin as antibacterial dressings for improved wound healing.
32314510	4	21	theme	composite	473:481	arg1	hydrogels					483:491	The composite hydrogels	469:491	The composite hydrogels	469:491	The composite hydrogels were in situ formed by electrostatic interactions, chelation interactions, and covalent bonds between carboxylated chitosan and DR under ultraviolet assisted without small photosensitizer.
32314510	8	22	theme	present	985:991	arg1	study					993:997	The present study	981:997	The present study	981:997	The present study demonstrates this composite DR-CCH with trace zinc has potential for accelerated wound healing.
32314510	3	23	theme	wound	454:458	arg1	healing					460:466	improved wound healing	445:466	improved wound healing	445:466	Herein, we developed chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing.
32314510	5	24	theme	physiological	780:792	arg1	buffers					794:800	physiological buffers	780:800	physiological buffers	780:800	The resultant hydrogels (noted as DR-CCH) showed good stability at different DR concentrations in physiological buffers.
32314510	2	25	theme	bacterial	265:273	arg1	infection					275:283	bacterial infection	265:283	bacterial infection	265:283	Developing efficacious wound dressings could effectively prevent bacterial infection and accelerate wound healing.
32314510	5	26	dep	hydrogels	696:704	arg1	noted					707:711	noted	707:711	noted as DR-CCH	707:721	The resultant hydrogels (noted as DR-CCH) showed good stability at different DR concentrations in physiological buffers.
32314510	4	27	theme	covalent	572:579	arg1	bonds					581:585	covalent bonds	572:585	covalent bonds	572:585	The composite hydrogels were in situ formed by electrostatic interactions, chelation interactions, and covalent bonds between carboxylated chitosan and DR under ultraviolet assisted without small photosensitizer.
32314510	3	28	theme	chitosan	336:343	arg1	hydrogels					355:363	chitosan composite hydrogels	336:363	chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR)	336:412	Herein, we developed chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing.
32314510	3	28	theme	chitosan	336:343	arg1	dressings					431:439	antibacterial dressings	417:439	antibacterial dressings for improved wound healing	417:466	Herein, we developed chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing.
32314510	1	29	theme	Skin	128:131	arg1	lesions					133:139	Skin lesions	128:139	Skin lesions	128:139	Skin lesions and injuries can increase the risk of pathogen infections.
32314510	3	30	theme	improved	445:452	arg1	healing					460:466	improved wound healing	445:466	improved wound healing	445:466	Herein, we developed chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing.
32314510	4	31	theme	carboxylated	595:606	arg1	chitosan					608:615	chitosan	608:615	chitosan	608:615	The composite hydrogels were in situ formed by electrostatic interactions, chelation interactions, and covalent bonds between carboxylated chitosan and DR under ultraviolet assisted without small photosensitizer.
32314510	3	32	theme	composite	345:353	arg1	hydrogels					355:363	chitosan composite hydrogels	336:363	chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR)	336:412	Herein, we developed chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing.
32314510	3	32	theme	composite	345:353	arg1	dressings					431:439	antibacterial dressings	417:439	antibacterial dressings for improved wound healing	417:466	Herein, we developed chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing.
32314510	8	33	theme	composite	1017:1025	arg1	DR-CCH					1027:1032	this composite DR-CCH with trace zinc has potential for accelerated wound healing	1012:1092	this composite DR-CCH with trace zinc has potential for accelerated wound healing	1012:1092	The present study demonstrates this composite DR-CCH with trace zinc has potential for accelerated wound healing.
32314510	5	34	theme	different	749:757	arg1	concentrations					762:775	different DR concentrations	749:775	different DR concentrations in physiological buffers	749:800	The resultant hydrogels (noted as DR-CCH) showed good stability at different DR concentrations in physiological buffers.
32314510	2	35	theme	wound	223:227	arg1	dressings					229:237	Developing efficacious wound dressings	200:237	Developing efficacious wound dressings	200:237	Developing efficacious wound dressings could effectively prevent bacterial infection and accelerate wound healing.
32314510	2	36	theme	wound	300:304	arg1	healing					306:312	wound healing	300:312	wound healing	300:312	Developing efficacious wound dressings could effectively prevent bacterial infection and accelerate wound healing.
32314510	5	37	theme	DR	759:760	arg1	concentrations					762:775	different DR concentrations	749:775	different DR concentrations in physiological buffers	749:800	The resultant hydrogels (noted as DR-CCH) showed good stability at different DR concentrations in physiological buffers.
32314510	2	38	theme	efficacious	211:221	arg1	dressings					229:237	Developing efficacious wound dressings	200:237	Developing efficacious wound dressings	200:237	Developing efficacious wound dressings could effectively prevent bacterial infection and accelerate wound healing.
32314510	0	39	dep	hydrogels	19:27	arg1	cross-linked					29:40	cross-linked	29:40	hydrogels cross-linked by multifunctional diazo resin as antibacterial dressings for improved wound healing	19:125	Chitosan composite hydrogels cross-linked by multifunctional diazo resin as antibacterial dressings for improved wound healing.
32314510	0	40	theme	antibacterial	76:88	arg1	dressings					90:98	antibacterial dressings	76:98	antibacterial dressings for improved wound healing	76:125	Chitosan composite hydrogels cross-linked by multifunctional diazo resin as antibacterial dressings for improved wound healing.
32314510	2	41	theme	Developing	200:209	arg1	dressings					229:237	Developing efficacious wound dressings	200:237	Developing efficacious wound dressings	200:237	Developing efficacious wound dressings could effectively prevent bacterial infection and accelerate wound healing.
32314510	6	42	theme	antibacterial	807:819	arg1	assays					821:826	The antibacterial assays	803:826	The antibacterial assays	803:826	The antibacterial assays showed the DR-CCH could inhibit and kill Escherichia coli and Staphylococcus aureus.
32314510	3	43	theme	multifunctional	381:395	arg1	resin					403:407	multifunctional diazo resin	381:407	multifunctional diazo resin (DR)	381:412	Herein, we developed chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing.
32314510	3	43	theme	multifunctional	381:395	arg1	DR					410:411	DR	410:411	DR	410:411	Herein, we developed chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing.
34294810	0	0	theme	substrates	87:96	arg1	effects					29:35	the modulatory effects	14:35	the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm	14:138	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.
34294810	6	1	theme	reduced	880:886	arg1	virulence					888:896	a reduced virulence	878:896	a reduced virulence	878:896	Besides a beneficial compositional shift, NADM-treated biofilms also showed an altered metabolism, a reduced virulence and a decreased inflammatory potential.
34294810	10	2	theme	biofilm	1417:1423	arg1	virulence					1450:1458	virulence	1450:1458	virulence	1450:1458	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	2	theme	biofilm	1417:1423	arg1	potential					1477:1485	inflammatory potential	1464:1485	inflammatory potential	1464:1485	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	2	theme	biofilm	1417:1423	arg1	metabolism					1438:1447	metabolism	1438:1447	metabolism	1438:1447	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	2	theme	biofilm	1417:1423	arg1	composition					1425:1435	in vitro multi-species oral biofilm composition	1389:1435	in vitro multi-species oral biofilm composition	1389:1435	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	5	3	theme	NADG	724:727	arg1	-mannose					738:745	NADM, NADG and D-(+)-mannose	718:745	NADM, NADG and D-(+)-mannose	718:745	Therefore, a comparison was made between the effects of NADM, NADG and D-(+)-mannose on multi-species oral biofilms.
34294810	0	4	theme	prebiotic	77:85	arg1	substrates					87:96	three structurally similar potential prebiotic substrates	40:96	three structurally similar potential prebiotic substrates	40:96	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.
34294810	1	5	theme	potential	170:178	arg1	substrates					190:199	potential prebiotic substrates	170:199	potential prebiotic substrates for oral health	170:215	Previous research identified potential prebiotic substrates for oral health like the structural analogues N-acetyl-D-mannosamine (NADM) and N-acetyl-D-glucosamine (NADG).
34294810	11	6	dep	presence	1492:1499	arg1	The					1488:1490	The	1488:1490	The	1488:1490	The presence and orientation of the N-acetyl group influenced these effects.
34294810	5	7	from	effects	707:713	arg1	biofilms					769:776	multi-species oral biofilms	750:776	multi-species oral biofilms	750:776	Therefore, a comparison was made between the effects of NADM, NADG and D-(+)-mannose on multi-species oral biofilms.
34294810	7	8	dep	pronounced	994:1003	arg1	whereas					1030:1036	whereas	1030:1036	whereas	1030:1036	At a substrate concentration of 1 M, these effects were pronounced for all biofilm aspects, whereas at ~ 0.05 M (1%(w/v)) only the effects on virulence were pronounced.
34294810	0	9	from	Comparison	0:9	arg1	biofilm					132:138	an in vitro multi-species oral biofilm	101:138	an in vitro multi-species oral biofilm	101:138	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.
34294810	3	10	theme	inflammatory	556:567	arg1	potential					569:577	inflammatory potential	556:577	inflammatory potential	556:577	Firstly, it was hypothesized that the modulatory effects of NADM are not limited to changes in multi-species oral biofilm composition, but also include effects on metabolism, virulence, and inflammatory potential.
34294810	10	11	contain	have	1317:1320	arg1	NADM					1299:1302	NADM	1299:1302	NADM	1299:1302	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	11	contain	have	1317:1320	arg2	effects					1332:1338	different effects	1322:1338	different effects	1322:1338	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	5	12	theme	NADM	718:721	arg1	-mannose					738:745	NADM, NADG and D-(+)-mannose	718:745	NADM, NADG and D-(+)-mannose	718:745	Therefore, a comparison was made between the effects of NADM, NADG and D-(+)-mannose on multi-species oral biofilms.
34294810	3	13	from	effects	518:524	arg1	virulence					541:549	virulence	541:549	virulence	541:549	Firstly, it was hypothesized that the modulatory effects of NADM are not limited to changes in multi-species oral biofilm composition, but also include effects on metabolism, virulence, and inflammatory potential.
34294810	3	13	from	effects	518:524	arg1	metabolism					529:538	metabolism	529:538	metabolism	529:538	Firstly, it was hypothesized that the modulatory effects of NADM are not limited to changes in multi-species oral biofilm composition, but also include effects on metabolism, virulence, and inflammatory potential.
34294810	3	13	from	effects	518:524	arg1	potential					569:577	inflammatory potential	556:577	inflammatory potential	556:577	Firstly, it was hypothesized that the modulatory effects of NADM are not limited to changes in multi-species oral biofilm composition, but also include effects on metabolism, virulence, and inflammatory potential.
34294810	0	14	dep	in	104:105	arg1	vitro					107:111	vitro	107:111	vitro	107:111	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.
34294810	6	15	theme	altered	858:864	arg1	metabolism					866:875	an altered metabolism	855:875	an altered metabolism	855:875	Besides a beneficial compositional shift, NADM-treated biofilms also showed an altered metabolism, a reduced virulence and a decreased inflammatory potential.
34294810	10	16	theme	in	1389:1390	arg1	virulence					1450:1458	virulence	1450:1458	virulence	1450:1458	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	16	theme	in	1389:1390	arg1	potential					1477:1485	inflammatory potential	1464:1485	inflammatory potential	1464:1485	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	16	theme	in	1389:1390	arg1	metabolism					1438:1447	metabolism	1438:1447	metabolism	1438:1447	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	16	theme	in	1389:1390	arg1	composition					1425:1435	in vitro multi-species oral biofilm composition	1389:1435	in vitro multi-species oral biofilm composition	1389:1435	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	4	17	theme	N-acetyl	628:635	arg1	group					637:641	their N-acetyl group	622:641	their N-acetyl group	622:641	Secondly, the presence and orientation of their N-acetyl group could play a role.
34294810	10	18	theme	inflammatory	1464:1475	arg1	potential					1477:1485	inflammatory potential	1464:1485	inflammatory potential	1464:1485	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	18	theme	inflammatory	1464:1475	arg1	composition					1425:1435	in vitro multi-species oral biofilm composition	1389:1435	in vitro multi-species oral biofilm composition	1389:1435	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	1	19	theme	prebiotic	180:188	arg1	substrates					190:199	potential prebiotic substrates	170:199	potential prebiotic substrates for oral health	170:215	Previous research identified potential prebiotic substrates for oral health like the structural analogues N-acetyl-D-mannosamine (NADM) and N-acetyl-D-glucosamine (NADG).
34294810	0	20	theme	in	104:105	arg1	biofilm					132:138	an in vitro multi-species oral biofilm	101:138	an in vitro multi-species oral biofilm	101:138	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.
34294810	7	21	dep	effects	1069:1075	arg1	%					1052:1052	1%	1051:1052	1%(w/v)	1051:1057	At a substrate concentration of 1 M, these effects were pronounced for all biofilm aspects, whereas at ~ 0.05 M (1%(w/v)) only the effects on virulence were pronounced.
34294810	7	21	dep	effects	1069:1075	arg1	w/v					1054:1056	w/v	1054:1056	w/v	1054:1056	At a substrate concentration of 1 M, these effects were pronounced for all biofilm aspects, whereas at ~ 0.05 M (1%(w/v)) only the effects on virulence were pronounced.
34294810	10	22	theme	different	1322:1330	arg1	effects					1332:1338	different effects	1322:1338	different effects	1322:1338	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	7	23	from	concentration	953:965	arg1	pronounced					994:1003	pronounced	994:1003	pronounced	994:1003	At a substrate concentration of 1 M, these effects were pronounced for all biofilm aspects, whereas at ~ 0.05 M (1%(w/v)) only the effects on virulence were pronounced.
34294810	5	24	theme	oral	764:767	arg1	biofilms					769:776	multi-species oral biofilms	750:776	multi-species oral biofilms	750:776	Therefore, a comparison was made between the effects of NADM, NADG and D-(+)-mannose on multi-species oral biofilms.
34294810	0	25	from	effects	29:35	arg1	biofilm					132:138	an in vitro multi-species oral biofilm	101:138	an in vitro multi-species oral biofilm	101:138	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.
34294810	7	26	theme	biofilm	1013:1019	arg1	aspects					1021:1027	all biofilm aspects	1009:1027	all biofilm aspects	1009:1027	At a substrate concentration of 1 M, these effects were pronounced for all biofilm aspects, whereas at ~ 0.05 M (1%(w/v)) only the effects on virulence were pronounced.
34294810	8	27	theme	N-acetyl	1183:1190	arg1	group					1192:1196	the N-acetyl group	1179:1196	the N-acetyl group	1179:1196	When comparing between substrates, both the presence and orientation of the N-acetyl group played a role.
34294810	8	28	theme	group	1192:1196	arg1	orientation					1164:1174	orientation	1164:1174	orientation	1164:1174	When comparing between substrates, both the presence and orientation of the N-acetyl group played a role.
34294810	8	28	theme	group	1192:1196	arg1	presence					1151:1158	presence	1151:1158	presence	1151:1158	When comparing between substrates, both the presence and orientation of the N-acetyl group played a role.
34294810	1	29	theme	oral	205:208	arg1	health					210:215	oral health	205:215	oral health	205:215	Previous research identified potential prebiotic substrates for oral health like the structural analogues N-acetyl-D-mannosamine (NADM) and N-acetyl-D-glucosamine (NADG).
34294810	0	30	theme	modulatory	18:27	arg1	effects					29:35	the modulatory effects	14:35	the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm	14:138	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.
34294810	0	31	theme	oral	127:130	arg1	biofilm					132:138	an in vitro multi-species oral biofilm	101:138	an in vitro multi-species oral biofilm	101:138	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.
34294810	3	32	theme	multi-species	461:473	arg1	composition					488:498	multi-species oral biofilm composition	461:498	multi-species oral biofilm composition	461:498	Firstly, it was hypothesized that the modulatory effects of NADM are not limited to changes in multi-species oral biofilm composition, but also include effects on metabolism, virulence, and inflammatory potential.
34294810	7	33	theme	1 M	970:972	arg1	concentration					953:965	a substrate concentration	941:965	a substrate concentration of 1 M	941:972	At a substrate concentration of 1 M, these effects were pronounced for all biofilm aspects, whereas at ~ 0.05 M (1%(w/v)) only the effects on virulence were pronounced.
34294810	0	34	theme	multi-species	113:125	arg1	biofilm					132:138	an in vitro multi-species oral biofilm	101:138	an in vitro multi-species oral biofilm	101:138	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.
34294810	4	35	dep	presence	594:601	arg1	the					590:592	the	590:592	the	590:592	Secondly, the presence and orientation of their N-acetyl group could play a role.
34294810	2	36	theme	main	316:319	arg1	hypothesis					321:330	The main hypothesis	312:330	The main hypothesis of the current study	312:351	The main hypothesis of the current study was twofold.
34294810	2	36	theme	main	316:319	arg1	twofold					357:363	twofold	357:363	twofold	357:363	The main hypothesis of the current study was twofold.
34294810	3	37	theme	oral	475:478	arg1	composition					488:498	multi-species oral biofilm composition	461:498	multi-species oral biofilm composition	461:498	Firstly, it was hypothesized that the modulatory effects of NADM are not limited to changes in multi-species oral biofilm composition, but also include effects on metabolism, virulence, and inflammatory potential.
34294810	10	38	theme	multi-species	1398:1410	arg1	virulence					1450:1458	virulence	1450:1458	virulence	1450:1458	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	38	theme	multi-species	1398:1410	arg1	potential					1477:1485	inflammatory potential	1464:1485	inflammatory potential	1464:1485	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	38	theme	multi-species	1398:1410	arg1	metabolism					1438:1447	metabolism	1438:1447	metabolism	1438:1447	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	38	theme	multi-species	1398:1410	arg1	composition					1425:1435	in vitro multi-species oral biofilm composition	1389:1435	in vitro multi-species oral biofilm composition	1389:1435	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	0	39	theme	effects	29:35	arg1	Comparison					0:9	Comparison	0:9	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.	0:139	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.
34294810	6	40	theme	inflammatory	914:925	arg1	potential					927:935	a decreased inflammatory potential	902:935	a decreased inflammatory potential	902:935	Besides a beneficial compositional shift, NADM-treated biofilms also showed an altered metabolism, a reduced virulence and a decreased inflammatory potential.
34294810	3	41	theme	NADM	426:429	arg1	limited					439:445	limited	439:445	limited	439:445	Firstly, it was hypothesized that the modulatory effects of NADM are not limited to changes in multi-species oral biofilm composition, but also include effects on metabolism, virulence, and inflammatory potential.
34294810	3	41	theme	NADM	426:429	arg1	effects					415:421	the modulatory effects	400:421	the modulatory effects of NADM	400:429	Firstly, it was hypothesized that the modulatory effects of NADM are not limited to changes in multi-species oral biofilm composition, but also include effects on metabolism, virulence, and inflammatory potential.
34294810	1	42	dep	analogues	237:245	arg1	NADM					271:274	NADM	271:274	NADM	271:274	Previous research identified potential prebiotic substrates for oral health like the structural analogues N-acetyl-D-mannosamine (NADM) and N-acetyl-D-glucosamine (NADG).
34294810	1	42	dep	analogues	237:245	arg1	N-acetyl-D-mannosamine					247:268	N-acetyl-D-mannosamine	247:268	the structural analogues N-acetyl-D-mannosamine (NADM)	222:275	Previous research identified potential prebiotic substrates for oral health like the structural analogues N-acetyl-D-mannosamine (NADM) and N-acetyl-D-glucosamine (NADG).
34294810	10	43	dep	in	1389:1390	arg1	vitro					1392:1396	vitro	1392:1396	vitro	1392:1396	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	3	44	from	changes	450:456	arg1	composition					488:498	multi-species oral biofilm composition	461:498	multi-species oral biofilm composition	461:498	Firstly, it was hypothesized that the modulatory effects of NADM are not limited to changes in multi-species oral biofilm composition, but also include effects on metabolism, virulence, and inflammatory potential.
34294810	1	45	theme	structural	226:235	arg1	analogues					237:245	the structural analogues N-acetyl-D-mannosamine (NADM)	222:275	the structural analogues N-acetyl-D-mannosamine (NADM)	222:275	Previous research identified potential prebiotic substrates for oral health like the structural analogues N-acetyl-D-mannosamine (NADM) and N-acetyl-D-glucosamine (NADG).
34294810	3	46	theme	modulatory	404:413	arg1	limited					439:445	limited	439:445	limited	439:445	Firstly, it was hypothesized that the modulatory effects of NADM are not limited to changes in multi-species oral biofilm composition, but also include effects on metabolism, virulence, and inflammatory potential.
34294810	3	46	theme	modulatory	404:413	arg1	effects					415:421	the modulatory effects	400:421	the modulatory effects of NADM	400:429	Firstly, it was hypothesized that the modulatory effects of NADM are not limited to changes in multi-species oral biofilm composition, but also include effects on metabolism, virulence, and inflammatory potential.
34294810	6	47	theme	decreased	904:912	arg1	potential					927:935	a decreased inflammatory potential	902:935	a decreased inflammatory potential	902:935	Besides a beneficial compositional shift, NADM-treated biofilms also showed an altered metabolism, a reduced virulence and a decreased inflammatory potential.
34294810	5	48	theme	D-	733:734	arg1	-mannose					738:745	NADM, NADG and D-(+)-mannose	718:745	NADM, NADG and D-(+)-mannose	718:745	Therefore, a comparison was made between the effects of NADM, NADG and D-(+)-mannose on multi-species oral biofilms.
34294810	11	49	theme	N-acetyl	1524:1531	arg1	group					1533:1537	the N-acetyl group	1520:1537	the N-acetyl group	1520:1537	The presence and orientation of the N-acetyl group influenced these effects.
34294810	5	50	theme	multi-species	750:762	arg1	biofilms					769:776	multi-species oral biofilms	750:776	multi-species oral biofilms	750:776	Therefore, a comparison was made between the effects of NADM, NADG and D-(+)-mannose on multi-species oral biofilms.
34294810	3	51	theme	biofilm	480:486	arg1	composition					488:498	multi-species oral biofilm composition	461:498	multi-species oral biofilm composition	461:498	Firstly, it was hypothesized that the modulatory effects of NADM are not limited to changes in multi-species oral biofilm composition, but also include effects on metabolism, virulence, and inflammatory potential.
34294810	6	52	theme	NADM-treated	821:832	arg1	biofilms					834:841	NADM-treated biofilms	821:841	NADM-treated biofilms	821:841	Besides a beneficial compositional shift, NADM-treated biofilms also showed an altered metabolism, a reduced virulence and a decreased inflammatory potential.
34294810	8	53	dep	presence	1151:1158	arg1	the					1147:1149	the	1147:1149	the	1147:1149	When comparing between substrates, both the presence and orientation of the N-acetyl group played a role.
34294810	6	54	theme	compositional	800:812	arg1	shift					814:818	a beneficial compositional shift	787:818	a beneficial compositional shift	787:818	Besides a beneficial compositional shift, NADM-treated biofilms also showed an altered metabolism, a reduced virulence and a decreased inflammatory potential.
34294810	7	55	from	effects	1069:1075	arg1	virulence					1080:1088	virulence	1080:1088	virulence	1080:1088	At a substrate concentration of 1 M, these effects were pronounced for all biofilm aspects, whereas at ~ 0.05 M (1%(w/v)) only the effects on virulence were pronounced.
34294810	2	56	theme	study	347:351	arg1	hypothesis					321:330	The main hypothesis	312:330	The main hypothesis of the current study	312:351	The main hypothesis of the current study was twofold.
34294810	2	56	theme	study	347:351	arg1	twofold					357:363	twofold	357:363	twofold	357:363	The main hypothesis of the current study was twofold.
34294810	11	57	theme	group	1533:1537	arg1	orientation					1505:1515	orientation	1505:1515	orientation	1505:1515	The presence and orientation of the N-acetyl group influenced these effects.
34294810	11	57	theme	group	1533:1537	arg1	presence					1492:1499	presence	1492:1499	presence	1492:1499	The presence and orientation of the N-acetyl group influenced these effects.
34294810	6	58	theme	beneficial	789:798	arg1	shift					814:818	a beneficial compositional shift	787:818	a beneficial compositional shift	787:818	Besides a beneficial compositional shift, NADM-treated biofilms also showed an altered metabolism, a reduced virulence and a decreased inflammatory potential.
34294810	2	59	theme	current	339:345	arg1	study					347:351	the current study	335:351	the current study	335:351	The main hypothesis of the current study was twofold.
34294810	0	60	from	biofilm	132:138	arg1	Comparison					0:9	Comparison	0:9	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.	0:139	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.
34294810	0	61	theme	potential	67:75	arg1	substrates					87:96	three structurally similar potential prebiotic substrates	40:96	three structurally similar potential prebiotic substrates	40:96	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.
34294810	4	62	theme	group	637:641	arg1	orientation					607:617	orientation	607:617	orientation	607:617	Secondly, the presence and orientation of their N-acetyl group could play a role.
34294810	4	62	theme	group	637:641	arg1	presence					594:601	presence	594:601	presence	594:601	Secondly, the presence and orientation of their N-acetyl group could play a role.
34294810	1	63	theme	Previous	141:148	arg1	research					150:157	Previous research	141:157	Previous research	141:157	Previous research identified potential prebiotic substrates for oral health like the structural analogues N-acetyl-D-mannosamine (NADM) and N-acetyl-D-glucosamine (NADG).
34294810	10	64	theme	oral	1412:1415	arg1	virulence					1450:1458	virulence	1450:1458	virulence	1450:1458	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	64	theme	oral	1412:1415	arg1	potential					1477:1485	inflammatory potential	1464:1485	inflammatory potential	1464:1485	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	64	theme	oral	1412:1415	arg1	metabolism					1438:1447	metabolism	1438:1447	metabolism	1438:1447	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	10	64	theme	oral	1412:1415	arg1	composition					1425:1435	in vitro multi-species oral biofilm composition	1389:1435	in vitro multi-species oral biofilm composition	1389:1435	Overall, NADM was found to have different effects at two concentrations that beneficially modulate in vitro multi-species oral biofilm composition, metabolism, virulence and inflammatory potential.
34294810	0	65	theme	similar	59:65	arg1	substrates					87:96	three structurally similar potential prebiotic substrates	40:96	three structurally similar potential prebiotic substrates	40:96	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.
34294810	5	66	theme	-mannose	738:745	arg1	effects					707:713	the effects	703:713	the effects of NADM, NADG and D-(+)-mannose on multi-species oral biofilms	703:776	Therefore, a comparison was made between the effects of NADM, NADG and D-(+)-mannose on multi-species oral biofilms.
34294810	7	67	theme	substrate	943:951	arg1	concentration					953:965	a substrate concentration	941:965	a substrate concentration of 1 M	941:972	At a substrate concentration of 1 M, these effects were pronounced for all biofilm aspects, whereas at ~ 0.05 M (1%(w/v)) only the effects on virulence were pronounced.
34294810	9	68	theme	biofilm	1274:1280	arg1	aspect					1282:1287	the biofilm aspect	1270:1287	the biofilm aspect	1270:1287	However, this was generally only at 1 M and dependent on the biofilm aspect.
31984728	6	0	theme	surface	975:981	arg1	properties					983:992	surface properties	975:992	surface properties (surface charge, ζ potential)	975:1022	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	10	1	theme	water-based	1813:1823	arg1	systems					1825:1831	water-based systems	1813:1831	water-based systems	1813:1831	Our work illustrates that amphiphilic CNCs can complement associative polymers as modifiers of rheological properties of water-based systems.
31984728	6	2	dep	properties	983:992	arg1	charge					1003:1008	surface charge	995:1008	surface charge	995:1008	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	6	2	dep	properties	983:992	arg1	potential					1013:1021	ζ potential	1011:1021	ζ potential	1011:1021	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	3	3	theme	amphiphilic	610:620	arg1	properties					622:631	their self-assembly and amphiphilic properties	586:631	their self-assembly and amphiphilic properties in suspensions and gels	586:655	In this study, we investigate the properties of hydrophobized cellulose nanocrystals (CNCs) and their self-assembly and amphiphilic properties in suspensions and gels.
31984728	4	4	theme	primary	739:745	arg1	alkylamines					747:757	coupling primary alkylamines	730:757	coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms)	730:818	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	3	5	theme	self-assembly	592:604	arg1	properties					622:631	their self-assembly and amphiphilic properties	586:631	their self-assembly and amphiphilic properties in suspensions and gels	586:655	In this study, we investigate the properties of hydrophobized cellulose nanocrystals (CNCs) and their self-assembly and amphiphilic properties in suspensions and gels.
31984728	1	6	theme	composites	205:214	arg1	development					160:170	the development	156:170	the development of nanofiller-reinforced polymer composites and formulations based on Pickering emulsions	156:260	Surface hydrophobization of cellulose nanomaterials has been used in the development of nanofiller-reinforced polymer composites and formulations based on Pickering emulsions.
31984728	2	7	theme	polymer	365:371	arg1	amphiphiles					373:383	water-soluble polymer amphiphiles	351:383	water-soluble polymer amphiphiles	351:383	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	1	8	theme	formulations	220:231	arg1	development					160:170	the development	156:170	the development of nanofiller-reinforced polymer composites and formulations based on Pickering emulsions	156:260	Surface hydrophobization of cellulose nanomaterials has been used in the development of nanofiller-reinforced polymer composites and formulations based on Pickering emulsions.
31984728	6	9	theme	hydrophilic	1195:1205	arg1	CNCs					1207:1210	hydrophilic CNCs	1195:1210	hydrophilic CNCs	1195:1210	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	4	10	theme	sulfated	713:720	arg1	CNCs					722:725	sulfated CNCs	713:725	sulfated CNCs	713:725	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	9	11	theme	sol-gel	1541:1547	arg1	transitions					1549:1559	sol-gel transitions	1541:1559	sol-gel transitions for hydrophobized CNCs	1541:1582	In particular, sol-gel transitions for hydrophobized CNCs occur at lower concentrations than hydrophilic CNCs, and more robust gels are formed by hydrophobized CNCs.
31984728	5	12	theme	surface	868:874	arg1	charge					876:881	surface charge	868:881	surface charge	868:881	The synthetic route permitted the retention of surface charge, ensuring good colloidal stability of hydrophobized CNCs in aqueous suspensions.
31984728	5	13	theme	colloidal	898:906	arg1	stability					908:916	good colloidal stability	893:916	good colloidal stability of hydrophobized CNCs in aqueous suspensions	893:961	The synthetic route permitted the retention of surface charge, ensuring good colloidal stability of hydrophobized CNCs in aqueous suspensions.
31984728	4	14	theme	carbon	806:811	arg1	lengths					784:790	different alkyl chain lengths	762:790	different alkyl chain lengths (6, 8, and 12 carbon atoms)	762:818	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	4	14	theme	carbon	806:811	arg1	atoms					813:817	6, 8, and 12 carbon atoms	793:817	6, 8, and 12 carbon atoms	793:817	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	2	15	theme	hydrophobic	296:306	arg1	domains					308:314	hydrophobic domains	296:314	hydrophobic domains	296:314	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	6	16	theme	microenvironment	1062:1077	arg1	angle					1055:1059	water contact angle	1041:1059	water contact angle	1041:1059	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	6	16	theme	microenvironment	1062:1077	arg1	probing					1079:1085	microenvironment probing	1062:1085	microenvironment probing using pyrene fluorescence emission	1062:1120	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	8	17	theme	CNC	1378:1380	arg1	association					1382:1392	CNC association	1378:1392	CNC association	1378:1392	As a result of CNC association, CNC suspensions/gels can be produced with a wide range of rheological properties depending on the hydrophobic/hydrophilic balance.
31984728	7	18	theme	X-ray	1293:1297	arg1	SAXS					1311:1314	SAXS	1311:1314	SAXS	1311:1314	Association of hydrophobized CNCs driven by hydrophobic effects is confirmed by X-ray scattering (SAXS) and autofluorescent spectroscopy experiments.
31984728	7	18	theme	X-ray	1293:1297	arg1	scattering					1299:1308	X-ray scattering	1293:1308	X-ray scattering (SAXS)	1293:1315	Association of hydrophobized CNCs driven by hydrophobic effects is confirmed by X-ray scattering (SAXS) and autofluorescent spectroscopy experiments.
31984728	0	19	theme	Cellulose	20:28	arg1	Nanocrystals					30:41	Cellulose Nanocrystals	20:41	Cellulose Nanocrystals	20:41	Hydrophobization of Cellulose Nanocrystals for Aqueous Colloidal Suspensions and Gels.
31984728	5	20	from	stability	908:916	arg1	suspensions					951:961	aqueous suspensions	943:961	aqueous suspensions	943:961	The synthetic route permitted the retention of surface charge, ensuring good colloidal stability of hydrophobized CNCs in aqueous suspensions.
31984728	5	21	theme	aqueous	943:949	arg1	suspensions					951:961	aqueous suspensions	943:961	aqueous suspensions	943:961	The synthetic route permitted the retention of surface charge, ensuring good colloidal stability of hydrophobized CNCs in aqueous suspensions.
31984728	6	22	dep	hydrophobicity	1025:1038	arg1	angle					1055:1059	water contact angle	1041:1059	water contact angle	1041:1059	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	6	22	dep	hydrophobicity	1025:1038	arg1	probing					1079:1085	microenvironment probing	1062:1085	microenvironment probing using pyrene fluorescence emission	1062:1120	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	4	23	theme	lengths	784:790	arg1	alkylamines					747:757	coupling primary alkylamines	730:757	coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms)	730:818	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	1	24	theme	nanofiller-reinforced	175:195	arg1	composites					205:214	nanofiller-reinforced polymer composites	175:214	nanofiller-reinforced polymer composites	175:214	Surface hydrophobization of cellulose nanomaterials has been used in the development of nanofiller-reinforced polymer composites and formulations based on Pickering emulsions.
31984728	6	25	theme	water	1041:1045	arg1	angle					1055:1059	water contact angle	1041:1059	water contact angle	1041:1059	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	6	25	theme	water	1041:1045	arg1	probing					1079:1085	microenvironment probing	1062:1085	microenvironment probing using pyrene fluorescence emission	1062:1120	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	2	26	theme	nanomaterials	458:470	arg1	behavior					422:429	the behavior	418:429	the behavior of hydrophobized cellulose nanomaterials in aqueous media	418:487	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	0	27	theme	Aqueous	47:53	arg1	Suspensions					65:75	Aqueous Colloidal Suspensions	47:75	Aqueous Colloidal Suspensions	47:75	Hydrophobization of Cellulose Nanocrystals for Aqueous Colloidal Suspensions and Gels.
31984728	1	28	theme	Surface	87:93	arg1	hydrophobization					95:110	Surface hydrophobization	87:110	Surface hydrophobization of cellulose nanomaterials	87:137	Surface hydrophobization of cellulose nanomaterials has been used in the development of nanofiller-reinforced polymer composites and formulations based on Pickering emulsions.
31984728	2	29	theme	hydrophobized	434:446	arg1	nanomaterials					458:470	hydrophobized cellulose nanomaterials	434:470	hydrophobized cellulose nanomaterials	434:470	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	7	30	theme	CNCs	1242:1245	arg1	Association					1213:1223	Association	1213:1223	Association of hydrophobized CNCs driven by hydrophobic effects	1213:1275	Association of hydrophobized CNCs driven by hydrophobic effects is confirmed by X-ray scattering (SAXS) and autofluorescent spectroscopy experiments.
31984728	8	31	theme	wide	1439:1442	arg1	range					1444:1448	a wide range	1437:1448	a wide range of rheological properties	1437:1474	As a result of CNC association, CNC suspensions/gels can be produced with a wide range of rheological properties depending on the hydrophobic/hydrophilic balance.
31984728	5	32	theme	charge	876:881	arg1	retention					855:863	the retention	851:863	the retention of surface charge	851:881	The synthetic route permitted the retention of surface charge, ensuring good colloidal stability of hydrophobized CNCs in aqueous suspensions.
31984728	1	33	theme	nanomaterials	125:137	arg1	hydrophobization					95:110	Surface hydrophobization	87:110	Surface hydrophobization of cellulose nanomaterials	87:137	Surface hydrophobization of cellulose nanomaterials has been used in the development of nanofiller-reinforced polymer composites and formulations based on Pickering emulsions.
31984728	6	34	theme	fluorescence	1100:1111	arg1	emission					1113:1120	pyrene fluorescence emission	1093:1120	pyrene fluorescence emission	1093:1120	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	2	35	theme	aqueous	475:481	arg1	media					483:487	aqueous media	475:487	aqueous media	475:487	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	9	36	theme	hydrophobized	1672:1684	arg1	CNCs					1686:1689	hydrophobized CNCs	1672:1689	hydrophobized CNCs	1672:1689	In particular, sol-gel transitions for hydrophobized CNCs occur at lower concentrations than hydrophilic CNCs, and more robust gels are formed by hydrophobized CNCs.
31984728	8	37	theme	properties	1465:1474	arg1	range					1444:1448	a wide range	1437:1448	a wide range of rheological properties	1437:1474	As a result of CNC association, CNC suspensions/gels can be produced with a wide range of rheological properties depending on the hydrophobic/hydrophilic balance.
31984728	3	38	theme	cellulose	552:560	arg1	CNCs					576:579	CNCs	576:579	CNCs	576:579	In this study, we investigate the properties of hydrophobized cellulose nanocrystals (CNCs) and their self-assembly and amphiphilic properties in suspensions and gels.
31984728	3	38	theme	cellulose	552:560	arg1	nanocrystals					562:573	hydrophobized cellulose nanocrystals	538:573	hydrophobized cellulose nanocrystals (CNCs)	538:580	In this study, we investigate the properties of hydrophobized cellulose nanocrystals (CNCs) and their self-assembly and amphiphilic properties in suspensions and gels.
31984728	0	39	theme	Colloidal	55:63	arg1	Suspensions					65:75	Aqueous Colloidal Suspensions	47:75	Aqueous Colloidal Suspensions	47:75	Hydrophobization of Cellulose Nanocrystals for Aqueous Colloidal Suspensions and Gels.
31984728	6	40	theme	hydrophobized	1172:1184	arg1	CNCs					1186:1189	different hydrophobized CNCs	1162:1189	different hydrophobized CNCs	1162:1189	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	3	41	from	properties	524:533	arg1	gels					652:655	gels	652:655	gels	652:655	In this study, we investigate the properties of hydrophobized cellulose nanocrystals (CNCs) and their self-assembly and amphiphilic properties in suspensions and gels.
31984728	3	41	from	properties	524:533	arg1	suspensions					636:646	suspensions	636:646	suspensions	636:646	In this study, we investigate the properties of hydrophobized cellulose nanocrystals (CNCs) and their self-assembly and amphiphilic properties in suspensions and gels.
31984728	10	42	theme	rheological	1787:1797	arg1	properties					1799:1808	rheological properties	1787:1808	rheological properties of water-based systems	1787:1831	Our work illustrates that amphiphilic CNCs can complement associative polymers as modifiers of rheological properties of water-based systems.
31984728	7	43	theme	autofluorescent	1321:1335	arg1	experiments					1350:1360	autofluorescent spectroscopy experiments	1321:1360	autofluorescent spectroscopy experiments	1321:1360	Association of hydrophobized CNCs driven by hydrophobic effects is confirmed by X-ray scattering (SAXS) and autofluorescent spectroscopy experiments.
31984728	4	44	theme	different	666:674	arg1	hydrophobicity					676:689	different hydrophobicity	666:689	different hydrophobicity	666:689	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	10	45	theme	properties	1799:1808	arg1	polymers					1762:1769	associative polymers	1750:1769	associative polymers	1750:1769	Our work illustrates that amphiphilic CNCs can complement associative polymers as modifiers of rheological properties of water-based systems.
31984728	10	45	theme	properties	1799:1808	arg1	modifiers					1774:1782	modifiers	1774:1782	modifiers of rheological properties of water-based systems	1774:1831	Our work illustrates that amphiphilic CNCs can complement associative polymers as modifiers of rheological properties of water-based systems.
31984728	8	46	theme	hydrophobic/hydrophilic	1493:1515	arg1	balance					1517:1523	the hydrophobic/hydrophilic balance	1489:1523	the hydrophobic/hydrophilic balance	1489:1523	As a result of CNC association, CNC suspensions/gels can be produced with a wide range of rheological properties depending on the hydrophobic/hydrophilic balance.
31984728	10	47	theme	systems	1825:1831	arg1	properties					1799:1808	rheological properties	1787:1808	rheological properties of water-based systems	1787:1831	Our work illustrates that amphiphilic CNCs can complement associative polymers as modifiers of rheological properties of water-based systems.
31984728	7	48	theme	spectroscopy	1337:1348	arg1	experiments					1350:1360	autofluorescent spectroscopy experiments	1321:1360	autofluorescent spectroscopy experiments	1321:1360	Association of hydrophobized CNCs driven by hydrophobic effects is confirmed by X-ray scattering (SAXS) and autofluorescent spectroscopy experiments.
31984728	1	49	theme	polymer	197:203	arg1	composites					205:214	nanofiller-reinforced polymer composites	175:214	nanofiller-reinforced polymer composites	175:214	Surface hydrophobization of cellulose nanomaterials has been used in the development of nanofiller-reinforced polymer composites and formulations based on Pickering emulsions.
31984728	4	50	theme	coupling	730:737	arg1	alkylamines					747:757	coupling primary alkylamines	730:757	coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms)	730:818	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	2	51	theme	amphiphiles	373:383	arg1	association					336:346	association	336:346	association	336:346	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	2	51	theme	amphiphiles	373:383	arg1	self-assembly					319:331	self-assembly	319:331	self-assembly	319:331	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	5	52	theme	hydrophobized	921:933	arg1	CNCs					935:938	hydrophobized CNCs	921:938	hydrophobized CNCs	921:938	The synthetic route permitted the retention of surface charge, ensuring good colloidal stability of hydrophobized CNCs in aqueous suspensions.
31984728	2	53	from	behavior	422:429	arg1	media					483:487	aqueous media	475:487	aqueous media	475:487	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	6	54	theme	CNCs	1207:1210	arg1	tensiometry					1146:1156	tensiometry	1146:1156	tensiometry	1146:1156	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	6	54	theme	CNCs	1207:1210	arg1	activity					1136:1143	surface activity	1128:1143	surface activity (tensiometry)	1128:1157	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	6	54	theme	CNCs	1207:1210	arg1	hydrophobicity					1025:1038	hydrophobicity	1025:1038	hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission)	1025:1121	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	6	54	theme	CNCs	1207:1210	arg1	properties					983:992	surface properties	975:992	surface properties (surface charge, ζ potential)	975:1022	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	2	55	theme	water-soluble	351:363	arg1	amphiphiles					373:383	water-soluble polymer amphiphiles	351:383	water-soluble polymer amphiphiles	351:383	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	1	56	used	used	148:151	arg2	hydrophobization					95:110	Surface hydrophobization	87:110	Surface hydrophobization of cellulose nanomaterials	87:137	Surface hydrophobization of cellulose nanomaterials has been used in the development of nanofiller-reinforced polymer composites and formulations based on Pickering emulsions.
31984728	4	57	theme	chain	778:782	arg1	lengths					784:790	different alkyl chain lengths	762:790	different alkyl chain lengths (6, 8, and 12 carbon atoms)	762:818	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	4	57	theme	chain	778:782	arg1	atoms					813:817	6, 8, and 12 carbon atoms	793:817	6, 8, and 12 carbon atoms	793:817	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	9	58	theme	hydrophilic	1619:1629	arg1	CNCs					1631:1634	hydrophilic CNCs	1619:1634	hydrophilic CNCs	1619:1634	In particular, sol-gel transitions for hydrophobized CNCs occur at lower concentrations than hydrophilic CNCs, and more robust gels are formed by hydrophobized CNCs.
31984728	2	59	theme	few	391:393	arg1	studies					395:401	very few studies	386:401	very few studies	386:401	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	2	60	theme	well-known	275:284	arg1	effect					286:291	the well-known effect	271:291	the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles	271:383	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	5	61	theme	CNCs	935:938	arg1	stability					908:916	good colloidal stability	893:916	good colloidal stability of hydrophobized CNCs in aqueous suspensions	893:961	The synthetic route permitted the retention of surface charge, ensuring good colloidal stability of hydrophobized CNCs in aqueous suspensions.
31984728	5	62	theme	good	893:896	arg1	stability					908:916	good colloidal stability	893:916	good colloidal stability of hydrophobized CNCs in aqueous suspensions	893:961	The synthetic route permitted the retention of surface charge, ensuring good colloidal stability of hydrophobized CNCs in aqueous suspensions.
31984728	9	63	theme	hydrophobized	1565:1577	arg1	CNCs					1579:1582	hydrophobized CNCs	1565:1582	hydrophobized CNCs	1565:1582	In particular, sol-gel transitions for hydrophobized CNCs occur at lower concentrations than hydrophilic CNCs, and more robust gels are formed by hydrophobized CNCs.
31984728	6	64	theme	surface	995:1001	arg1	charge					1003:1008	surface charge	995:1008	surface charge	995:1008	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	6	64	theme	surface	995:1001	arg1	potential					1013:1021	ζ potential	1011:1021	ζ potential	1011:1021	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	3	65	from	properties	622:631	arg1	gels					652:655	gels	652:655	gels	652:655	In this study, we investigate the properties of hydrophobized cellulose nanocrystals (CNCs) and their self-assembly and amphiphilic properties in suspensions and gels.
31984728	3	65	from	properties	622:631	arg1	suspensions					636:646	suspensions	636:646	suspensions	636:646	In this study, we investigate the properties of hydrophobized cellulose nanocrystals (CNCs) and their self-assembly and amphiphilic properties in suspensions and gels.
31984728	2	66	theme	domains	308:314	arg1	effect					286:291	the well-known effect	271:291	the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles	271:383	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	9	67	theme	lower	1593:1597	arg1	concentrations					1599:1612	lower concentrations	1593:1612	lower concentrations than hydrophilic CNCs	1593:1634	In particular, sol-gel transitions for hydrophobized CNCs occur at lower concentrations than hydrophilic CNCs, and more robust gels are formed by hydrophobized CNCs.
31984728	4	68	theme	different	762:770	arg1	lengths					784:790	different alkyl chain lengths	762:790	different alkyl chain lengths (6, 8, and 12 carbon atoms)	762:818	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	4	68	theme	different	762:770	arg1	atoms					813:817	6, 8, and 12 carbon atoms	793:817	6, 8, and 12 carbon atoms	793:817	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	6	69	theme	contact	1047:1053	arg1	angle					1055:1059	water contact angle	1041:1059	water contact angle	1041:1059	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	6	69	theme	contact	1047:1053	arg1	probing					1079:1085	microenvironment probing	1062:1085	microenvironment probing using pyrene fluorescence emission	1062:1120	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	8	70	theme	association	1382:1392	arg1	result					1368:1373	a result	1366:1373	a result of CNC association	1366:1392	As a result of CNC association, CNC suspensions/gels can be produced with a wide range of rheological properties depending on the hydrophobic/hydrophilic balance.
31984728	8	70	theme	association	1382:1392	arg1	suspensions/gels					1399:1414	CNC suspensions/gels	1395:1414	CNC suspensions/gels	1395:1414	As a result of CNC association, CNC suspensions/gels can be produced with a wide range of rheological properties depending on the hydrophobic/hydrophilic balance.
31984728	7	71	theme	hydrophobic	1257:1267	arg1	effects					1269:1275	hydrophobic effects	1257:1275	hydrophobic effects	1257:1275	Association of hydrophobized CNCs driven by hydrophobic effects is confirmed by X-ray scattering (SAXS) and autofluorescent spectroscopy experiments.
31984728	8	72	theme	CNC	1395:1397	arg1	result					1368:1373	a result	1366:1373	a result of CNC association	1366:1392	As a result of CNC association, CNC suspensions/gels can be produced with a wide range of rheological properties depending on the hydrophobic/hydrophilic balance.
31984728	8	72	theme	CNC	1395:1397	arg1	suspensions/gels					1399:1414	CNC suspensions/gels	1395:1414	CNC suspensions/gels	1395:1414	As a result of CNC association, CNC suspensions/gels can be produced with a wide range of rheological properties depending on the hydrophobic/hydrophilic balance.
31984728	6	73	theme	surface	1128:1134	arg1	tensiometry					1146:1156	tensiometry	1146:1156	tensiometry	1146:1156	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	6	73	theme	surface	1128:1134	arg1	activity					1136:1143	surface activity	1128:1143	surface activity (tensiometry)	1128:1157	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	2	74	theme	cellulose	448:456	arg1	nanomaterials					458:470	hydrophobized cellulose nanomaterials	434:470	hydrophobized cellulose nanomaterials	434:470	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	7	75	theme	hydrophobized	1228:1240	arg1	CNCs					1242:1245	hydrophobized CNCs	1228:1245	hydrophobized CNCs driven by hydrophobic effects	1228:1275	Association of hydrophobized CNCs driven by hydrophobic effects is confirmed by X-ray scattering (SAXS) and autofluorescent spectroscopy experiments.
31984728	9	76	theme	robust	1646:1651	arg1	gels					1653:1656	more robust gels	1641:1656	more robust gels	1641:1656	In particular, sol-gel transitions for hydrophobized CNCs occur at lower concentrations than hydrophilic CNCs, and more robust gels are formed by hydrophobized CNCs.
31984728	10	77	theme	amphiphilic	1718:1728	arg1	CNCs					1730:1733	amphiphilic CNCs	1718:1733	amphiphilic CNCs	1718:1733	Our work illustrates that amphiphilic CNCs can complement associative polymers as modifiers of rheological properties of water-based systems.
31984728	0	78	theme	Nanocrystals	30:41	arg1	Hydrophobization					0:15	Hydrophobization	0:15	Hydrophobization of Cellulose Nanocrystals for Aqueous Colloidal Suspensions and Gels.	0:85	Hydrophobization of Cellulose Nanocrystals for Aqueous Colloidal Suspensions and Gels.
31984728	1	79	theme	cellulose	115:123	arg1	nanomaterials					125:137	cellulose nanomaterials	115:137	cellulose nanomaterials	115:137	Surface hydrophobization of cellulose nanomaterials has been used in the development of nanofiller-reinforced polymer composites and formulations based on Pickering emulsions.
31984728	2	80	from	effect	286:291	arg1	association					336:346	association	336:346	association	336:346	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	2	80	from	effect	286:291	arg1	self-assembly					319:331	self-assembly	319:331	self-assembly	319:331	Despite the well-known effect of hydrophobic domains on self-assembly or association of water-soluble polymer amphiphiles, very few studies have addressed the behavior of hydrophobized cellulose nanomaterials in aqueous media.
31984728	5	81	theme	synthetic	825:833	arg1	route					835:839	The synthetic route	821:839	The synthetic route	821:839	The synthetic route permitted the retention of surface charge, ensuring good colloidal stability of hydrophobized CNCs in aqueous suspensions.
31984728	1	82	theme	Pickering	242:250	arg1	emulsions					252:260	Pickering emulsions	242:260	Pickering emulsions	242:260	Surface hydrophobization of cellulose nanomaterials has been used in the development of nanofiller-reinforced polymer composites and formulations based on Pickering emulsions.
31984728	6	83	theme	pyrene	1093:1098	arg1	emission					1113:1120	pyrene fluorescence emission	1093:1120	pyrene fluorescence emission	1093:1120	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	4	84	theme	alkyl	772:776	arg1	lengths					784:790	different alkyl chain lengths	762:790	different alkyl chain lengths (6, 8, and 12 carbon atoms)	762:818	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	4	84	theme	alkyl	772:776	arg1	atoms					813:817	6, 8, and 12 carbon atoms	793:817	6, 8, and 12 carbon atoms	793:817	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	10	85	theme	associative	1750:1760	arg1	polymers					1762:1769	associative polymers	1750:1769	associative polymers	1750:1769	Our work illustrates that amphiphilic CNCs can complement associative polymers as modifiers of rheological properties of water-based systems.
31984728	10	85	theme	associative	1750:1760	arg1	modifiers					1774:1782	modifiers	1774:1782	modifiers of rheological properties of water-based systems	1774:1831	Our work illustrates that amphiphilic CNCs can complement associative polymers as modifiers of rheological properties of water-based systems.
31984728	6	86	theme	CNCs	1186:1189	arg1	tensiometry					1146:1156	tensiometry	1146:1156	tensiometry	1146:1156	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	6	86	theme	CNCs	1186:1189	arg1	activity					1136:1143	surface activity	1128:1143	surface activity (tensiometry)	1128:1157	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	6	86	theme	CNCs	1186:1189	arg1	hydrophobicity					1025:1038	hydrophobicity	1025:1038	hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission)	1025:1121	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	6	86	theme	CNCs	1186:1189	arg1	properties					983:992	surface properties	975:992	surface properties (surface charge, ζ potential)	975:1022	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	8	87	theme	rheological	1453:1463	arg1	properties					1465:1474	rheological properties	1453:1474	rheological properties	1453:1474	As a result of CNC association, CNC suspensions/gels can be produced with a wide range of rheological properties depending on the hydrophobic/hydrophilic balance.
31984728	3	88	theme	nanocrystals	562:573	arg1	properties					622:631	their self-assembly and amphiphilic properties	586:631	their self-assembly and amphiphilic properties in suspensions and gels	586:655	In this study, we investigate the properties of hydrophobized cellulose nanocrystals (CNCs) and their self-assembly and amphiphilic properties in suspensions and gels.
31984728	3	88	theme	nanocrystals	562:573	arg1	properties					524:533	the properties	520:533	the properties of hydrophobized cellulose nanocrystals (CNCs)	520:580	In this study, we investigate the properties of hydrophobized cellulose nanocrystals (CNCs) and their self-assembly and amphiphilic properties in suspensions and gels.
31984728	6	89	theme	different	1162:1170	arg1	CNCs					1186:1189	different hydrophobized CNCs	1162:1189	different hydrophobized CNCs	1162:1189	We compare surface properties (surface charge, ζ potential), hydrophobicity (water contact angle, microenvironment probing using pyrene fluorescence emission), and surface activity (tensiometry) of different hydrophobized CNCs and hydrophilic CNCs.
31984728	4	90	theme	hydrophobicity	676:689	arg1	CNCs					658:661	CNCs	658:661	CNCs of different hydrophobicity	658:689	CNCs of different hydrophobicity were synthesized from sulfated CNCs by coupling primary alkylamines of different alkyl chain lengths (6, 8, and 12 carbon atoms).
31984728	3	91	theme	hydrophobized	538:550	arg1	CNCs					576:579	CNCs	576:579	CNCs	576:579	In this study, we investigate the properties of hydrophobized cellulose nanocrystals (CNCs) and their self-assembly and amphiphilic properties in suspensions and gels.
31984728	3	91	theme	hydrophobized	538:550	arg1	nanocrystals					562:573	hydrophobized cellulose nanocrystals	538:573	hydrophobized cellulose nanocrystals (CNCs)	538:580	In this study, we investigate the properties of hydrophobized cellulose nanocrystals (CNCs) and their self-assembly and amphiphilic properties in suspensions and gels.
33135713	5	0	theme	Diclofenac	653:662	arg1	drug					739:742	a model drug	731:742	a model drug	731:742	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	5	0	theme	Diclofenac	653:662	arg1	DS					672:673	DS	672:673	DS	672:673	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	5	0	theme	Diclofenac	653:662	arg1	drug					709:712	a hydrophilic anti-inflammatory drug	677:712	a hydrophilic anti-inflammatory drug	677:712	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	5	0	theme	Diclofenac	653:662	arg1	Sodium					664:669	Diclofenac Sodium	653:669	Diclofenac Sodium (DS)	653:674	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	2	1	theme	air	376:378	arg1	filters					380:386	high-efficiency particulate air filters	348:386	high-efficiency particulate air filters	348:386	This platform offers versatile applications including in tissue engineering, drug delivery, wound dressings, and high-efficiency particulate air filters.
33135713	1	2	used	used	157:160	arg2	technology					137:146	Electrospun nanofiber (EN) technology	110:146	Electrospun nanofiber (EN) technology	110:146	Electrospun nanofiber (EN) technology has been used in the past to generate electrostatically charged multilayer-nanofibers.
33135713	4	3	theme	payload	588:594	arg1	delivery					596:603	high payload delivery	583:603	high payload delivery	583:603	The fabricated NNEMs were utilized for high payload delivery and controlled release of a water-soluble drug.
33135713	11	4	theme	3T3	1438:1440	arg1	adhesion					1447:1454	3T3 cell adhesion	1438:1454	3T3 cell adhesion	1438:1454	DS-NNEMs also enhanced 3T3 cell adhesion, viability, and proliferation in the nanonet-nano fiber network through the controlled release of DS.
33135713	2	5	theme	tissue	292:297	arg1	engineering					299:309	tissue engineering	292:309	tissue engineering	292:309	This platform offers versatile applications including in tissue engineering, drug delivery, wound dressings, and high-efficiency particulate air filters.
33135713	6	6	theme	NNEMs	870:874	arg1	compositions					839:850	Various compositions	831:850	Various compositions of DS drug-loaded NNEMs (DS-NNEMs)	831:885	Various compositions of DS drug-loaded NNEMs (DS-NNEMs) were synthesized.
33135713	5	7	with	compatibility	792:804	arg1	polymers					821:828	insoluble polymers	811:828	insoluble polymers	811:828	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	2	8	theme	wound	327:331	arg1	dressings					333:341	wound dressings	327:341	wound dressings	327:341	This platform offers versatile applications including in tissue engineering, drug delivery, wound dressings, and high-efficiency particulate air filters.
33135713	12	9	theme	drugs	1780:1784	arg1	loading					1747:1753	loading	1747:1753	loading	1747:1753	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	12	9	theme	drugs	1780:1784	arg1	release					1759:1765	release	1759:1765	release of antiviral drugs	1759:1784	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	5	10	theme	anti-inflammatory	691:707	arg1	Sodium					664:669	Diclofenac Sodium	653:669	Diclofenac Sodium (DS)	653:674	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	5	10	theme	anti-inflammatory	691:707	arg1	drug					709:712	a hydrophilic anti-inflammatory drug	677:712	a hydrophilic anti-inflammatory drug	677:712	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	9	11	theme	3T3	1234:1236	arg1	cells					1238:1242	NIH 3T3 cells	1230:1242	NIH 3T3 cells	1230:1242	Furthermore, the biocompatibility of the DS-NNEMs was tested with NIH 3T3 cells.
33135713	12	12	theme	hydrophilic	1670:1680	arg1	drugs					1700:1704	hydrophilic anti-inflammatory drugs	1670:1704	hydrophilic anti-inflammatory drugs	1670:1704	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	12	13	theme	controlled	1648:1657	arg1	release					1659:1665	the controlled release	1644:1665	the controlled release of hydrophilic anti-inflammatory drugs	1644:1704	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	4	14	theme	drug	647:650	arg1	delivery					596:603	high payload delivery	583:603	high payload delivery	583:603	The fabricated NNEMs were utilized for high payload delivery and controlled release of a water-soluble drug.
33135713	4	14	theme	drug	647:650	arg1	release					620:626	controlled release	609:626	controlled release of a water-soluble drug	609:650	The fabricated NNEMs were utilized for high payload delivery and controlled release of a water-soluble drug.
33135713	4	15	used	utilized	570:577	arg2	NNEMs					559:563	The fabricated NNEMs	544:563	The fabricated NNEMs	544:563	The fabricated NNEMs were utilized for high payload delivery and controlled release of a water-soluble drug.
33135713	11	16	theme	nanonet-nano	1493:1504	arg1	network					1512:1518	the nanonet-nano fiber network	1489:1518	the nanonet-nano fiber network	1489:1518	DS-NNEMs also enhanced 3T3 cell adhesion, viability, and proliferation in the nanonet-nano fiber network through the controlled release of DS.
33135713	12	17	theme	technology-based	1575:1590	arg1	limited					1632:1638	limited	1632:1638	limited	1632:1638	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	12	17	theme	technology-based	1575:1590	arg1	material					1611:1618	The presented EN technology-based biodegradable NNEM material	1558:1618	The presented EN technology-based biodegradable NNEM material	1558:1618	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	2	18	theme	versatile	256:264	arg1	applications					266:277	versatile applications	256:277	versatile applications including in tissue engineering, drug delivery, wound dressings, and high-efficiency particulate air filters	256:386	This platform offers versatile applications including in tissue engineering, drug delivery, wound dressings, and high-efficiency particulate air filters.
33135713	12	19	theme	NNEM	1606:1609	arg1	limited					1632:1638	limited	1632:1638	limited	1632:1638	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	12	19	theme	NNEM	1606:1609	arg1	material					1611:1618	The presented EN technology-based biodegradable NNEM material	1558:1618	The presented EN technology-based biodegradable NNEM material	1558:1618	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	11	20	theme	DS	1554:1555	arg1	release					1543:1549	the controlled release	1528:1549	the controlled release of DS	1528:1555	DS-NNEMs also enhanced 3T3 cell adhesion, viability, and proliferation in the nanonet-nano fiber network through the controlled release of DS.
33135713	10	21	theme	physicochemical	1249:1263	arg1	results					1282:1288	The physicochemical characterization results	1245:1288	The physicochemical characterization results	1245:1288	The physicochemical characterization results showed that the DS drug is a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning.
33135713	0	22	theme	diclofenac	91:100	arg1	sodium					102:107	diclofenac sodium	91:107	diclofenac sodium	91:107	Nanonet-nano fiber electrospun mesh of PCL-chitosan for controlled and extended release of diclofenac sodium.
33135713	12	23	theme	presented	1562:1570	arg1	limited					1632:1638	limited	1632:1638	limited	1632:1638	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	12	23	theme	presented	1562:1570	arg1	material					1611:1618	The presented EN technology-based biodegradable NNEM material	1558:1618	The presented EN technology-based biodegradable NNEM material	1558:1618	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	10	24	theme	DS	1306:1307	arg1	factor					1336:1341	a key contributing factor	1317:1341	a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning	1317:1412	The physicochemical characterization results showed that the DS drug is a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning.
33135713	10	24	theme	DS	1306:1307	arg1	drug					1309:1312	the DS drug	1302:1312	the DS drug	1302:1312	The physicochemical characterization results showed that the DS drug is a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning.
33135713	3	25	theme	electrospun	456:466	arg1	NNEMs					476:480	NNEMs	476:480	NNEMs	476:480	In this study, we synthesized for the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology.
33135713	3	25	theme	electrospun	456:466	arg1	meshes					468:473	nanonet-nanofiber electrospun meshes	438:473	the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology	423:541	In this study, we synthesized for the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology.
33135713	8	26	theme	High	1045:1048	arg1	efficiency					1066:1075	High drug entrapment efficiency	1045:1075	High drug entrapment efficiency	1045:1075	High drug entrapment efficiency and concentration-dependent drug release patterns were investigated for up to 14 days.
33135713	10	27	from	factor	1336:1341	arg1	generation					1350:1359	the generation	1346:1359	the generation of nanonet-nanofiber networks during electrospinning	1346:1412	The physicochemical characterization results showed that the DS drug is a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning.
33135713	0	28	theme	extended	71:78	arg1	release					80:86	controlled and extended release	56:86	controlled and extended release of diclofenac sodium	56:107	Nanonet-nano fiber electrospun mesh of PCL-chitosan for controlled and extended release of diclofenac sodium.
33135713	0	29	theme	Nanonet-nano	0:11	arg1	mesh					31:34	Nanonet-nano fiber electrospun mesh	0:34	Nanonet-nano fiber electrospun mesh of PCL-chitosan for controlled and extended release of diclofenac sodium.	0:108	Nanonet-nano fiber electrospun mesh of PCL-chitosan for controlled and extended release of diclofenac sodium.
33135713	8	30	theme	entrapment	1055:1064	arg1	efficiency					1066:1075	High drug entrapment efficiency	1045:1075	High drug entrapment efficiency	1045:1075	High drug entrapment efficiency and concentration-dependent drug release patterns were investigated for up to 14 days.
33135713	7	31	theme	physicochemical	909:923	arg1	stability					979:987	aqueous stability	971:987	aqueous stability	971:987	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	7	31	theme	physicochemical	909:923	arg1	morphology					955:964	morphology	955:964	morphology	955:964	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	7	31	theme	physicochemical	909:923	arg1	properties					925:934	The physicochemical properties	905:934	The physicochemical properties such as structure, morphology, and aqueous stability	905:987	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	7	31	theme	physicochemical	909:923	arg1	structure					944:952	structure	944:952	structure	944:952	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	2	32	from	applications	266:277	arg1	filters					380:386	high-efficiency particulate air filters	348:386	high-efficiency particulate air filters	348:386	This platform offers versatile applications including in tissue engineering, drug delivery, wound dressings, and high-efficiency particulate air filters.
33135713	2	32	from	applications	266:277	arg1	engineering					299:309	tissue engineering	292:309	tissue engineering	292:309	This platform offers versatile applications including in tissue engineering, drug delivery, wound dressings, and high-efficiency particulate air filters.
33135713	2	32	from	applications	266:277	arg1	delivery					317:324	drug delivery	312:324	drug delivery	312:324	This platform offers versatile applications including in tissue engineering, drug delivery, wound dressings, and high-efficiency particulate air filters.
33135713	2	32	from	applications	266:277	arg1	dressings					333:341	wound dressings	327:341	wound dressings	327:341	This platform offers versatile applications including in tissue engineering, drug delivery, wound dressings, and high-efficiency particulate air filters.
33135713	10	33	theme	key	1319:1321	arg1	factor					1336:1341	a key contributing factor	1317:1341	a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning	1317:1412	The physicochemical characterization results showed that the DS drug is a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning.
33135713	10	33	theme	key	1319:1321	arg1	drug					1309:1312	the DS drug	1302:1312	the DS drug	1302:1312	The physicochemical characterization results showed that the DS drug is a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning.
33135713	0	34	theme	electrospun	19:29	arg1	mesh					31:34	Nanonet-nano fiber electrospun mesh	0:34	Nanonet-nano fiber electrospun mesh of PCL-chitosan for controlled and extended release of diclofenac sodium.	0:108	Nanonet-nano fiber electrospun mesh of PCL-chitosan for controlled and extended release of diclofenac sodium.
33135713	6	35	theme	drug-loaded	858:868	arg1	DS-NNEMs					877:884	DS-NNEMs	877:884	DS-NNEMs	877:884	Various compositions of DS drug-loaded NNEMs (DS-NNEMs) were synthesized.
33135713	6	35	theme	drug-loaded	858:868	arg1	NNEMs					870:874	DS drug-loaded NNEMs	855:874	DS drug-loaded NNEMs (DS-NNEMs)	855:885	Various compositions of DS drug-loaded NNEMs (DS-NNEMs) were synthesized.
33135713	1	36	theme	Electrospun	110:120	arg1	technology					137:146	Electrospun nanofiber (EN) technology	110:146	Electrospun nanofiber (EN) technology	110:146	Electrospun nanofiber (EN) technology has been used in the past to generate electrostatically charged multilayer-nanofibers.
33135713	12	37	theme	drugs	1700:1704	arg1	release					1659:1665	the controlled release	1644:1665	the controlled release of hydrophilic anti-inflammatory drugs	1644:1704	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	5	38	theme	high	759:762	arg1	solubility					772:781	its high aqueous solubility	755:781	its high aqueous solubility	755:781	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	8	39	theme	drug	1105:1108	arg1	patterns					1118:1125	concentration-dependent drug release patterns	1081:1125	concentration-dependent drug release patterns	1081:1125	High drug entrapment efficiency and concentration-dependent drug release patterns were investigated for up to 14 days.
33135713	2	40	theme	particulate	364:374	arg1	filters					380:386	high-efficiency particulate air filters	348:386	high-efficiency particulate air filters	348:386	This platform offers versatile applications including in tissue engineering, drug delivery, wound dressings, and high-efficiency particulate air filters.
33135713	6	41	theme	Various	831:837	arg1	compositions					839:850	Various compositions	831:850	Various compositions of DS drug-loaded NNEMs (DS-NNEMs)	831:885	Various compositions of DS drug-loaded NNEMs (DS-NNEMs) were synthesized.
33135713	3	42	theme	polycaprolactone	486:501	arg1	CH					519:520	CH	519:520	CH	519:520	In this study, we synthesized for the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology.
33135713	3	42	theme	polycaprolactone	486:501	arg1	-chitosan					508:516	polycaprolactone (PCL)-chitosan	486:516	polycaprolactone (PCL)-chitosan (CH) using EN technology	486:541	In this study, we synthesized for the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology.
33135713	3	43	theme	EN	529:530	arg1	technology					532:541	EN technology	529:541	EN technology	529:541	In this study, we synthesized for the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology.
33135713	10	44	theme	networks	1382:1389	arg1	generation					1350:1359	the generation	1346:1359	the generation of nanonet-nanofiber networks during electrospinning	1346:1412	The physicochemical characterization results showed that the DS drug is a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning.
33135713	5	45	theme	aqueous	764:770	arg1	solubility					772:781	its high aqueous solubility	755:781	its high aqueous solubility	755:781	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	4	46	theme	controlled	609:618	arg1	release					620:626	controlled release	609:626	controlled release of a water-soluble drug	609:650	The fabricated NNEMs were utilized for high payload delivery and controlled release of a water-soluble drug.
33135713	3	47	theme	-chitosan	508:516	arg1	time					433:436	the first time	423:436	the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology	423:541	In this study, we synthesized for the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology.
33135713	11	48	theme	cell	1442:1445	arg1	adhesion					1447:1454	3T3 cell adhesion	1438:1454	3T3 cell adhesion	1438:1454	DS-NNEMs also enhanced 3T3 cell adhesion, viability, and proliferation in the nanonet-nano fiber network through the controlled release of DS.
33135713	2	49	theme	drug	312:315	arg1	delivery					317:324	drug delivery	312:324	drug delivery	312:324	This platform offers versatile applications including in tissue engineering, drug delivery, wound dressings, and high-efficiency particulate air filters.
33135713	5	50	with	solubility	772:781	arg1	polymers					821:828	insoluble polymers	811:828	insoluble polymers	811:828	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	4	51	theme	high	583:586	arg1	delivery					596:603	high payload delivery	583:603	high payload delivery	583:603	The fabricated NNEMs were utilized for high payload delivery and controlled release of a water-soluble drug.
33135713	3	52	theme	PCL	504:506	arg1	CH					519:520	CH	519:520	CH	519:520	In this study, we synthesized for the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology.
33135713	3	52	theme	PCL	504:506	arg1	-chitosan					508:516	polycaprolactone (PCL)-chitosan	486:516	polycaprolactone (PCL)-chitosan (CH) using EN technology	486:541	In this study, we synthesized for the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology.
33135713	9	53	theme	DS-NNEMs	1205:1212	arg1	biocompatibility					1181:1196	the biocompatibility	1177:1196	the biocompatibility of the DS-NNEMs	1177:1212	Furthermore, the biocompatibility of the DS-NNEMs was tested with NIH 3T3 cells.
33135713	12	54	theme	antiviral	1770:1778	arg1	drugs					1780:1784	antiviral drugs	1770:1784	antiviral drugs	1770:1784	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	5	55	theme	hydrophilic	679:689	arg1	Sodium					664:669	Diclofenac Sodium	653:669	Diclofenac Sodium (DS)	653:674	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	5	55	theme	hydrophilic	679:689	arg1	drug					709:712	a hydrophilic anti-inflammatory drug	677:712	a hydrophilic anti-inflammatory drug	677:712	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	9	56	theme	NIH	1230:1232	arg1	cells					1238:1242	NIH 3T3 cells	1230:1242	NIH 3T3 cells	1230:1242	Furthermore, the biocompatibility of the DS-NNEMs was tested with NIH 3T3 cells.
33135713	5	57	theme	insoluble	811:819	arg1	polymers					821:828	insoluble polymers	811:828	insoluble polymers	811:828	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	11	58	theme	controlled	1532:1541	arg1	release					1543:1549	the controlled release	1528:1549	the controlled release of DS	1528:1555	DS-NNEMs also enhanced 3T3 cell adhesion, viability, and proliferation in the nanonet-nano fiber network through the controlled release of DS.
33135713	1	59	theme	charged	204:210	arg1	multilayer-nanofibers					212:232	electrostatically charged multilayer-nanofibers	186:232	electrostatically charged multilayer-nanofibers	186:232	Electrospun nanofiber (EN) technology has been used in the past to generate electrostatically charged multilayer-nanofibers.
33135713	4	60	theme	water-soluble	633:645	arg1	drug					647:650	a water-soluble drug	631:650	a water-soluble drug	631:650	The fabricated NNEMs were utilized for high payload delivery and controlled release of a water-soluble drug.
33135713	1	61	theme	nanofiber	122:130	arg1	technology					137:146	Electrospun nanofiber (EN) technology	110:146	Electrospun nanofiber (EN) technology	110:146	Electrospun nanofiber (EN) technology has been used in the past to generate electrostatically charged multilayer-nanofibers.
33135713	7	62	theme	DS-NNEMs	1020:1027	arg1	stability					979:987	aqueous stability	971:987	aqueous stability	971:987	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	7	62	theme	DS-NNEMs	1020:1027	arg1	morphology					955:964	morphology	955:964	morphology	955:964	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	7	62	theme	DS-NNEMs	1020:1027	arg1	properties					1006:1015	the chemical properties	993:1015	the chemical properties of DS-NNEMs	993:1027	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	7	62	theme	DS-NNEMs	1020:1027	arg1	properties					925:934	The physicochemical properties	905:934	The physicochemical properties such as structure, morphology, and aqueous stability	905:987	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	7	62	theme	DS-NNEMs	1020:1027	arg1	structure					944:952	structure	944:952	structure	944:952	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	7	63	theme	chemical	997:1004	arg1	stability					979:987	aqueous stability	971:987	aqueous stability	971:987	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	7	63	theme	chemical	997:1004	arg1	morphology					955:964	morphology	955:964	morphology	955:964	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	7	63	theme	chemical	997:1004	arg1	properties					1006:1015	the chemical properties	993:1015	the chemical properties of DS-NNEMs	993:1027	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	7	63	theme	chemical	997:1004	arg1	structure					944:952	structure	944:952	structure	944:952	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	1	64	theme	EN	133:134	arg1	technology					137:146	Electrospun nanofiber (EN) technology	110:146	Electrospun nanofiber (EN) technology	110:146	Electrospun nanofiber (EN) technology has been used in the past to generate electrostatically charged multilayer-nanofibers.
33135713	12	65	theme	biodegradable	1592:1604	arg1	limited					1632:1638	limited	1632:1638	limited	1632:1638	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	12	65	theme	biodegradable	1592:1604	arg1	material					1611:1618	The presented EN technology-based biodegradable NNEM material	1558:1618	The presented EN technology-based biodegradable NNEM material	1558:1618	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	11	66	theme	fiber	1506:1510	arg1	network					1512:1518	the nanonet-nano fiber network	1489:1518	the nanonet-nano fiber network	1489:1518	DS-NNEMs also enhanced 3T3 cell adhesion, viability, and proliferation in the nanonet-nano fiber network through the controlled release of DS.
33135713	5	67	theme	model	733:737	arg1	drug					739:742	a model drug	731:742	a model drug	731:742	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	5	67	theme	model	733:737	arg1	Sodium					664:669	Diclofenac Sodium	653:669	Diclofenac Sodium (DS)	653:674	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	7	68	theme	aqueous	971:977	arg1	stability					979:987	aqueous stability	971:987	aqueous stability	971:987	The physicochemical properties such as structure, morphology, and aqueous stability and the chemical properties of DS-NNEMs were evaluated.
33135713	10	69	theme	characterization	1265:1280	arg1	results					1282:1288	The physicochemical characterization results	1245:1288	The physicochemical characterization results	1245:1288	The physicochemical characterization results showed that the DS drug is a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning.
33135713	0	70	theme	sodium	102:107	arg1	release					80:86	controlled and extended release	56:86	controlled and extended release of diclofenac sodium	56:107	Nanonet-nano fiber electrospun mesh of PCL-chitosan for controlled and extended release of diclofenac sodium.
33135713	12	71	theme	suitable	1725:1732	arg1	platform					1734:1741	a suitable platform	1723:1741	a suitable platform for loading and release of antiviral drugs	1723:1784	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	12	72	theme	EN	1572:1573	arg1	limited					1632:1638	limited	1632:1638	limited	1632:1638	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	12	72	theme	EN	1572:1573	arg1	material					1611:1618	The presented EN technology-based biodegradable NNEM material	1558:1618	The presented EN technology-based biodegradable NNEM material	1558:1618	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	8	73	theme	drug	1050:1053	arg1	efficiency					1066:1075	High drug entrapment efficiency	1045:1075	High drug entrapment efficiency	1045:1075	High drug entrapment efficiency and concentration-dependent drug release patterns were investigated for up to 14 days.
33135713	8	74	dep	14	1155:1156	arg1	to					1152:1153	to	1152:1153	to	1152:1153	High drug entrapment efficiency and concentration-dependent drug release patterns were investigated for up to 14 days.
33135713	0	75	theme	fiber	13:17	arg1	mesh					31:34	Nanonet-nano fiber electrospun mesh	0:34	Nanonet-nano fiber electrospun mesh of PCL-chitosan for controlled and extended release of diclofenac sodium.	0:108	Nanonet-nano fiber electrospun mesh of PCL-chitosan for controlled and extended release of diclofenac sodium.
33135713	4	76	theme	fabricated	548:557	arg1	NNEMs					559:563	The fabricated NNEMs	544:563	The fabricated NNEMs	544:563	The fabricated NNEMs were utilized for high payload delivery and controlled release of a water-soluble drug.
33135713	10	77	theme	contributing	1323:1334	arg1	factor					1336:1341	a key contributing factor	1317:1341	a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning	1317:1412	The physicochemical characterization results showed that the DS drug is a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning.
33135713	10	77	theme	contributing	1323:1334	arg1	drug					1309:1312	the DS drug	1302:1312	the DS drug	1302:1312	The physicochemical characterization results showed that the DS drug is a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning.
33135713	3	78	theme	nanonet-nanofiber	438:454	arg1	NNEMs					476:480	NNEMs	476:480	NNEMs	476:480	In this study, we synthesized for the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology.
33135713	3	78	theme	nanonet-nanofiber	438:454	arg1	meshes					468:473	nanonet-nanofiber electrospun meshes	438:473	the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology	423:541	In this study, we synthesized for the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology.
33135713	5	79	theme	poor	787:790	arg1	compatibility					792:804	poor compatibility	787:804	poor compatibility	787:804	Diclofenac Sodium (DS), a hydrophilic anti-inflammatory drug, was selected as a model drug because of its high aqueous solubility and poor compatibility with insoluble polymers.
33135713	8	80	theme	concentration-dependent	1081:1103	arg1	patterns					1118:1125	concentration-dependent drug release patterns	1081:1125	concentration-dependent drug release patterns	1081:1125	High drug entrapment efficiency and concentration-dependent drug release patterns were investigated for up to 14 days.
33135713	0	81	theme	PCL-chitosan	39:50	arg1	mesh					31:34	Nanonet-nano fiber electrospun mesh	0:34	Nanonet-nano fiber electrospun mesh of PCL-chitosan for controlled and extended release of diclofenac sodium.	0:108	Nanonet-nano fiber electrospun mesh of PCL-chitosan for controlled and extended release of diclofenac sodium.
33135713	8	82	theme	release	1110:1116	arg1	patterns					1118:1125	concentration-dependent drug release patterns	1081:1125	concentration-dependent drug release patterns	1081:1125	High drug entrapment efficiency and concentration-dependent drug release patterns were investigated for up to 14 days.
33135713	6	83	theme	DS	855:856	arg1	DS-NNEMs					877:884	DS-NNEMs	877:884	DS-NNEMs	877:884	Various compositions of DS drug-loaded NNEMs (DS-NNEMs) were synthesized.
33135713	6	83	theme	DS	855:856	arg1	NNEMs					870:874	DS drug-loaded NNEMs	855:874	DS drug-loaded NNEMs (DS-NNEMs)	855:885	Various compositions of DS drug-loaded NNEMs (DS-NNEMs) were synthesized.
33135713	3	84	dep	time	433:436	arg1	NNEMs					476:480	NNEMs	476:480	NNEMs	476:480	In this study, we synthesized for the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology.
33135713	3	84	dep	time	433:436	arg1	meshes					468:473	nanonet-nanofiber electrospun meshes	438:473	the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology	423:541	In this study, we synthesized for the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology.
33135713	12	85	theme	anti-inflammatory	1682:1698	arg1	drugs					1700:1704	hydrophilic anti-inflammatory drugs	1670:1704	hydrophilic anti-inflammatory drugs	1670:1704	The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs.
33135713	3	86	theme	first	427:431	arg1	time					433:436	the first time	423:436	the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology	423:541	In this study, we synthesized for the first time nanonet-nanofiber electrospun meshes (NNEMs) of polycaprolactone (PCL)-chitosan (CH) using EN technology.
33135713	0	87	theme	controlled	56:65	arg1	release					80:86	controlled and extended release	56:86	controlled and extended release of diclofenac sodium	56:107	Nanonet-nano fiber electrospun mesh of PCL-chitosan for controlled and extended release of diclofenac sodium.
33135713	2	88	theme	high-efficiency	348:362	arg1	filters					380:386	high-efficiency particulate air filters	348:386	high-efficiency particulate air filters	348:386	This platform offers versatile applications including in tissue engineering, drug delivery, wound dressings, and high-efficiency particulate air filters.
33135713	10	89	theme	nanonet-nanofiber	1364:1380	arg1	networks					1382:1389	nanonet-nanofiber networks	1364:1389	nanonet-nanofiber networks	1364:1389	The physicochemical characterization results showed that the DS drug is a key contributing factor in the generation of nanonet-nanofiber networks during electrospinning.
32041154	1	0	with	polycaprolactone	156:171	arg1	compositions					225:236	different compositions	215:236	different compositions	215:236	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions was prepared using the electro-spinning method, with the objective of developing organic membranes with good mechanical properties to remove contaminants from water.
32041154	4	1	theme	nanometric	696:705	arg1	scale					707:711	a nanometric scale	694:711	a nanometric scale	694:711	The membranes obtained presented a porosity and structure on a nanometric scale.
32041154	5	2	theme	PCL/CNF	778:784	arg1	membranes					786:794	the PCL/CNF membranes	774:794	the PCL/CNF membranes	774:794	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	1	3	theme	good	342:345	arg1	properties					358:367	good mechanical properties	342:367	good mechanical properties	342:367	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions was prepared using the electro-spinning method, with the objective of developing organic membranes with good mechanical properties to remove contaminants from water.
32041154	7	4	theme	"	1061:1061	arg1	system					1091:1096	a "green" and eco-friendly filtration system	1053:1096	a "green" and eco-friendly filtration system for water purification	1053:1119	Electro-spun CNF and PCL membranes can be applied as a "green" and eco-friendly filtration system for water purification.
32041154	7	4	theme	"	1061:1061	arg1	membranes					1025:1033	Electro-spun CNF and PCL membranes	1000:1033	Electro-spun CNF and PCL membranes	1000:1033	Electro-spun CNF and PCL membranes can be applied as a "green" and eco-friendly filtration system for water purification.
32041154	5	5	theme	75	886:887	arg1	%					888:888	%	888:888	%	888:888	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	1	6	with	membranes	327:335	arg1	properties					358:367	good mechanical properties	342:367	good mechanical properties	342:367	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions was prepared using the electro-spinning method, with the objective of developing organic membranes with good mechanical properties to remove contaminants from water.
32041154	6	7	theme	tequila	956:962	arg1	production					964:973	tequila production	956:973	tequila production	956:973	CNF comprises biowaste derived from tequila production, and it has added value.
32041154	0	8	theme	Pollutants	103:112	arg1	Removal					92:98	the Removal	88:98	the Removal of Pollutants from Water	88:123	Nanocellulose and Polycaprolactone Nanospun Composite Membranes and Their Potential for the Removal of Pollutants from Water.
32041154	1	9	theme	mechanical	347:356	arg1	properties					358:367	good mechanical properties	342:367	good mechanical properties	342:367	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions was prepared using the electro-spinning method, with the objective of developing organic membranes with good mechanical properties to remove contaminants from water.
32041154	3	10	theme	polycaprolactone	534:549	arg1	nanofibers					551:560	polycaprolactone nanofibers	534:560	polycaprolactone nanofibers	534:560	In this sense, cellulose obtained from agave bagasse and polycaprolactone nanofibers was used to prepare membranes that were tested by filtering tap water.
32041154	1	11	theme	electro-spinning	261:276	arg1	method					278:283	the electro-spinning method	257:283	the electro-spinning method	257:283	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions was prepared using the electro-spinning method, with the objective of developing organic membranes with good mechanical properties to remove contaminants from water.
32041154	7	12	theme	water	1102:1106	arg1	purification					1108:1119	water purification	1102:1119	water purification	1102:1119	Electro-spun CNF and PCL membranes can be applied as a "green" and eco-friendly filtration system for water purification.
32041154	5	13	dep	%	888:888	arg1	to					890:891	to	890:891	to	890:891	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	5	14	theme	99	893:894	arg1	%					888:888	%	888:888	%	888:888	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	5	15	theme	heavy	850:854	arg1	removal					862:868	heavy metal removal	850:868	heavy metal removal of the order of 75% to 99% for iron and chromium	850:917	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	1	16	from	water	397:401	arg1	contaminants					379:390	contaminants	379:390	contaminants from water	379:401	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions was prepared using the electro-spinning method, with the objective of developing organic membranes with good mechanical properties to remove contaminants from water.
32041154	6	17	contain	has	983:985	arg1	it					980:981	it	980:981	it	980:981	CNF comprises biowaste derived from tequila production, and it has added value.
32041154	6	17	contain	has	983:985	arg2	value					993:997	added value	987:997	added value	987:997	CNF comprises biowaste derived from tequila production, and it has added value.
32041154	5	18	theme	metal	856:860	arg1	removal					862:868	heavy metal removal	850:868	heavy metal removal of the order of 75% to 99% for iron and chromium	850:917	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	5	19	theme	turbidity	808:816	arg1	removal					818:824	100% turbidity removal	803:824	100% turbidity removal	803:824	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	0	20	theme	Nanocellulose	0:12	arg1	Membranes					54:62	Nanocellulose and Polycaprolactone Nanospun Composite Membranes	0:62	Nanocellulose and Polycaprolactone Nanospun Composite Membranes	0:62	Nanocellulose and Polycaprolactone Nanospun Composite Membranes and Their Potential for the Removal of Pollutants from Water.
32041154	1	21	theme	cellulose	183:191	arg1	nanofibers					193:202	cellulose nanofibers	183:202	cellulose nanofibers	183:202	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions was prepared using the electro-spinning method, with the objective of developing organic membranes with good mechanical properties to remove contaminants from water.
32041154	2	22	theme	importance	435:444	arg1	Water					404:408	Water	404:408	Water	404:408	Water is a resource of primary importance for life and human activities.
32041154	2	22	theme	importance	435:444	arg1	resource					415:422	a resource	413:422	a resource of primary importance for life and human activities	413:474	Water is a resource of primary importance for life and human activities.
32041154	7	23	theme	PCL	1021:1023	arg1	system					1091:1096	a "green" and eco-friendly filtration system	1053:1096	a "green" and eco-friendly filtration system for water purification	1053:1119	Electro-spun CNF and PCL membranes can be applied as a "green" and eco-friendly filtration system for water purification.
32041154	7	23	theme	PCL	1021:1023	arg1	membranes					1025:1033	Electro-spun CNF and PCL membranes	1000:1033	Electro-spun CNF and PCL membranes	1000:1033	Electro-spun CNF and PCL membranes can be applied as a "green" and eco-friendly filtration system for water purification.
32041154	5	24	theme	%	895:895	arg1	order					877:881	the order	873:881	the order of 75% to 99% for iron and chromium	873:917	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	3	25	used	used	566:569	arg2	cellulose					492:500	cellulose	492:500	cellulose obtained from agave bagasse and polycaprolactone nanofibers	492:560	In this sense, cellulose obtained from agave bagasse and polycaprolactone nanofibers was used to prepare membranes that were tested by filtering tap water.
32041154	2	26	theme	primary	427:433	arg1	importance					435:444	primary importance	427:444	primary importance	427:444	Water is a resource of primary importance for life and human activities.
32041154	7	27	theme	CNF	1013:1015	arg1	system					1091:1096	a "green" and eco-friendly filtration system	1053:1096	a "green" and eco-friendly filtration system for water purification	1053:1119	Electro-spun CNF and PCL membranes can be applied as a "green" and eco-friendly filtration system for water purification.
32041154	7	27	theme	CNF	1013:1015	arg1	membranes					1025:1033	Electro-spun CNF and PCL membranes	1000:1033	Electro-spun CNF and PCL membranes	1000:1033	Electro-spun CNF and PCL membranes can be applied as a "green" and eco-friendly filtration system for water purification.
32041154	6	28	attach	derived	943:949	arg2	biowaste					934:941	biowaste	934:941	biowaste derived from tequila production	934:973	CNF comprises biowaste derived from tequila production, and it has added value.
32041154	6	28	attach	derived	943:949	arg1	production					964:973	tequila production	956:973	tequila production	956:973	CNF comprises biowaste derived from tequila production, and it has added value.
32041154	4	29	attach	presented	656:664	arg1	scale					707:711	a nanometric scale	694:711	a nanometric scale	694:711	The membranes obtained presented a porosity and structure on a nanometric scale.
32041154	4	29	attach	presented	656:664	arg2	membranes					637:645	The membranes	633:645	The membranes obtained	633:654	The membranes obtained presented a porosity and structure on a nanometric scale.
32041154	7	30	theme	filtration	1080:1089	arg1	system					1091:1096	a "green" and eco-friendly filtration system	1053:1096	a "green" and eco-friendly filtration system for water purification	1053:1119	Electro-spun CNF and PCL membranes can be applied as a "green" and eco-friendly filtration system for water purification.
32041154	7	30	theme	filtration	1080:1089	arg1	membranes					1025:1033	Electro-spun CNF and PCL membranes	1000:1033	Electro-spun CNF and PCL membranes	1000:1033	Electro-spun CNF and PCL membranes can be applied as a "green" and eco-friendly filtration system for water purification.
32041154	1	31	with	nanofibers	193:202	arg1	compositions					225:236	different compositions	215:236	different compositions	215:236	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions was prepared using the electro-spinning method, with the objective of developing organic membranes with good mechanical properties to remove contaminants from water.
32041154	0	32	theme	Composite	44:52	arg1	Membranes					54:62	Nanocellulose and Polycaprolactone Nanospun Composite Membranes	0:62	Nanocellulose and Polycaprolactone Nanospun Composite Membranes	0:62	Nanocellulose and Polycaprolactone Nanospun Composite Membranes and Their Potential for the Removal of Pollutants from Water.
32041154	5	33	theme	water	718:722	arg1	variables					732:740	The water quality variables	714:740	The water quality variables evaluated after filtration with the PCL/CNF membranes	714:794	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	0	34	theme	Nanospun	35:42	arg1	Membranes					54:62	Nanocellulose and Polycaprolactone Nanospun Composite Membranes	0:62	Nanocellulose and Polycaprolactone Nanospun Composite Membranes	0:62	Nanocellulose and Polycaprolactone Nanospun Composite Membranes and Their Potential for the Removal of Pollutants from Water.
32041154	6	35	theme	added	987:991	arg1	value					993:997	added value	987:997	added value	987:997	CNF comprises biowaste derived from tequila production, and it has added value.
32041154	2	36	theme	human	459:463	arg1	activities					465:474	human activities	459:474	human activities	459:474	Water is a resource of primary importance for life and human activities.
32041154	5	37	theme	quality	724:730	arg1	variables					732:740	The water quality variables	714:740	The water quality variables evaluated after filtration with the PCL/CNF membranes	714:794	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	5	38	theme	%	806:806	arg1	removal					818:824	100% turbidity removal	803:824	100% turbidity removal	803:824	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	1	39	theme	developing	308:317	arg1	membranes					327:335	developing organic membranes	308:335	developing organic membranes with good mechanical properties	308:367	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions was prepared using the electro-spinning method, with the objective of developing organic membranes with good mechanical properties to remove contaminants from water.
32041154	7	40	theme	Electro-spun	1000:1011	arg1	system					1091:1096	a "green" and eco-friendly filtration system	1053:1096	a "green" and eco-friendly filtration system for water purification	1053:1119	Electro-spun CNF and PCL membranes can be applied as a "green" and eco-friendly filtration system for water purification.
32041154	7	40	theme	Electro-spun	1000:1011	arg1	membranes					1025:1033	Electro-spun CNF and PCL membranes	1000:1033	Electro-spun CNF and PCL membranes	1000:1033	Electro-spun CNF and PCL membranes can be applied as a "green" and eco-friendly filtration system for water purification.
32041154	0	41	from	Water	119:123	arg1	Removal					92:98	the Removal	88:98	the Removal of Pollutants from Water	88:123	Nanocellulose and Polycaprolactone Nanospun Composite Membranes and Their Potential for the Removal of Pollutants from Water.
32041154	1	42	theme	organic	319:325	arg1	membranes					327:335	developing organic membranes	308:335	developing organic membranes with good mechanical properties	308:367	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions was prepared using the electro-spinning method, with the objective of developing organic membranes with good mechanical properties to remove contaminants from water.
32041154	7	43	theme	eco-friendly	1067:1078	arg1	system					1091:1096	a "green" and eco-friendly filtration system	1053:1096	a "green" and eco-friendly filtration system for water purification	1053:1119	Electro-spun CNF and PCL membranes can be applied as a "green" and eco-friendly filtration system for water purification.
32041154	7	43	theme	eco-friendly	1067:1078	arg1	membranes					1025:1033	Electro-spun CNF and PCL membranes	1000:1033	Electro-spun CNF and PCL membranes	1000:1033	Electro-spun CNF and PCL membranes can be applied as a "green" and eco-friendly filtration system for water purification.
32041154	3	44	theme	tap	622:624	arg1	water					626:630	tap water	622:630	tap water	622:630	In this sense, cellulose obtained from agave bagasse and polycaprolactone nanofibers was used to prepare membranes that were tested by filtering tap water.
32041154	1	45	theme	composite	128:136	arg1	membrane					138:145	A composite membrane	126:145	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions	126:236	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions was prepared using the electro-spinning method, with the objective of developing organic membranes with good mechanical properties to remove contaminants from water.
32041154	5	46	theme	order	877:881	arg1	removal					818:824	100% turbidity removal	803:824	100% turbidity removal	803:824	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	5	46	theme	order	877:881	arg1	removal					862:868	heavy metal removal	850:868	heavy metal removal of the order of 75% to 99% for iron and chromium	850:917	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	5	46	theme	order	877:881	arg1	conductivity					832:843	100% conductivity	827:843	100% conductivity	827:843	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	1	47	theme	different	215:223	arg1	compositions					225:236	different compositions	215:236	different compositions	215:236	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions was prepared using the electro-spinning method, with the objective of developing organic membranes with good mechanical properties to remove contaminants from water.
32041154	5	48	theme	%	830:830	arg1	conductivity					832:843	100% conductivity	827:843	100% conductivity	827:843	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	5	49	theme	100	803:805	arg1	%					806:806	%	806:806	%	806:806	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	1	50	theme	membranes	327:335	arg1	objective					295:303	the objective	291:303	the objective of developing organic membranes with good mechanical properties	291:367	A composite membrane based on polycaprolactone (PCL) and cellulose nanofibers (CNF) with different compositions was prepared using the electro-spinning method, with the objective of developing organic membranes with good mechanical properties to remove contaminants from water.
32041154	5	51	theme	100	827:829	arg1	%					830:830	%	830:830	%	830:830	The water quality variables evaluated after filtration with the PCL/CNF membranes showed 100% turbidity removal, 100% conductivity, and heavy metal removal of the order of 75% to 99% for iron and chromium.
32041154	3	52	theme	agave	516:520	arg1	bagasse					522:528	agave bagasse	516:528	agave bagasse	516:528	In this sense, cellulose obtained from agave bagasse and polycaprolactone nanofibers was used to prepare membranes that were tested by filtering tap water.
32053370	4	0	theme	molecular	657:665	arg1	weight					667:672	molecular weight	657:672	molecular weight	657:672	The color could be tuned across the visible spectrum by changing the concentration or molecular weight of the HPC.
32053370	3	1	theme	nematic	468:474	arg1	structure					476:484	a chiral nematic structure	459:484	a chiral nematic structure	459:484	In the composite CNC/HPC thin films, the CNCs adopt a chiral nematic structure, which can selectively reflect certain wavelengths of light to yield a colored film.
32053370	5	2	theme	tensile	835:841	arg1	strength					843:850	tensile strength	835:850	tensile strength	835:850	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	1	3	theme	responsive	252:261	arg1	materials					272:280	responsive photonic materials	252:280	responsive photonic materials	252:280	The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials.
32053370	5	4	theme	times	880:884	arg1	stiffness					821:829	stiffness	821:829	stiffness	821:829	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	5	4	theme	times	880:884	arg1	strength					843:850	tensile strength	835:850	tensile strength	835:850	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	1	5	theme	photonic	263:270	arg1	materials					272:280	responsive photonic materials	252:280	responsive photonic materials	252:280	The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials.
32053370	3	6	theme	light	540:544	arg1	wavelengths					525:535	certain wavelengths	517:535	certain wavelengths of light	517:544	In the composite CNC/HPC thin films, the CNCs adopt a chiral nematic structure, which can selectively reflect certain wavelengths of light to yield a colored film.
32053370	6	7	theme	Surface	901:907	arg1	modification					909:920	Surface modification	901:920	Surface modification of the films with methacrylate groups	901:958	Surface modification of the films with methacrylate groups increased the hydrophobicity of the films, and therefore, the water stability of these materials was also improved.
32053370	3	8	theme	certain	517:523	arg1	wavelengths					525:535	certain wavelengths	517:535	certain wavelengths of light	517:544	In the composite CNC/HPC thin films, the CNCs adopt a chiral nematic structure, which can selectively reflect certain wavelengths of light to yield a colored film.
32053370	5	9	dep	six	861:863	arg1	to					858:859	to	858:859	to	858:859	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	1	10	theme	materials	272:280	arg1	development					237:247	the development	233:247	the development of responsive photonic materials	233:280	The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials.
32053370	2	11	theme	cellulose	345:353	arg1	incorporation					314:326	the incorporation	310:326	the incorporation of hydroxypropyl cellulose (HPC) into a CNC film prepared by slow evaporation	310:404	In this study, we explored the incorporation of hydroxypropyl cellulose (HPC) into a CNC film prepared by slow evaporation.
32053370	6	12	theme	films	996:1000	arg1	hydrophobicity					974:987	the hydrophobicity	970:987	the hydrophobicity of the films	970:1000	Surface modification of the films with methacrylate groups increased the hydrophobicity of the films, and therefore, the water stability of these materials was also improved.
32053370	3	13	theme	composite	414:422	arg1	films					437:441	the composite CNC/HPC thin films	410:441	the composite CNC/HPC thin films	410:441	In the composite CNC/HPC thin films, the CNCs adopt a chiral nematic structure, which can selectively reflect certain wavelengths of light to yield a colored film.
32053370	5	14	theme	CNC	748:750	arg1	films					752:756	pure CNC films	743:756	pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively	743:898	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	6	15	theme	methacrylate	940:951	arg1	groups					953:958	methacrylate groups	940:958	methacrylate groups	940:958	Surface modification of the films with methacrylate groups increased the hydrophobicity of the films, and therefore, the water stability of these materials was also improved.
32053370	1	16	theme	mechanical	201:210	arg1	properties					212:221	optical and mechanical properties	189:221	optical and mechanical properties	189:221	The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials.
32053370	3	17	theme	CNC/HPC	424:430	arg1	films					437:441	the composite CNC/HPC thin films	410:441	the composite CNC/HPC thin films	410:441	In the composite CNC/HPC thin films, the CNCs adopt a chiral nematic structure, which can selectively reflect certain wavelengths of light to yield a colored film.
32053370	0	18	theme	Cellulose	11:19	arg1	Films					33:37	Iridescent Cellulose Nanocrystal Films	0:37	Iridescent Cellulose Nanocrystal Films	0:37	Iridescent Cellulose Nanocrystal Films Modified with Hydroxypropyl Cellulose.
32053370	1	19	theme	polymers	98:105	arg1	introduction					82:93	The introduction	78:93	The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix	78:162	The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials.
32053370	2	20	theme	CNC	368:370	arg1	film					372:375	a CNC film	366:375	a CNC film prepared by slow evaporation	366:404	In this study, we explored the incorporation of hydroxypropyl cellulose (HPC) into a CNC film prepared by slow evaporation.
32053370	0	21	theme	Iridescent	0:9	arg1	Films					33:37	Iridescent Cellulose Nanocrystal Films	0:37	Iridescent Cellulose Nanocrystal Films	0:37	Iridescent Cellulose Nanocrystal Films Modified with Hydroxypropyl Cellulose.
32053370	5	22	theme	times	865:869	arg1	stiffness					821:829	stiffness	821:829	stiffness	821:829	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	5	22	theme	times	865:869	arg1	strength					843:850	tensile strength	835:850	tensile strength	835:850	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	5	23	with	films	752:756	arg1	up					763:764	up	763:764	up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively	763:898	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	1	24	theme	optical	189:195	arg1	properties					212:221	optical and mechanical properties	189:221	optical and mechanical properties	189:221	The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials.
32053370	0	25	theme	Nanocrystal	21:31	arg1	Films					33:37	Iridescent Cellulose Nanocrystal Films	0:37	Iridescent Cellulose Nanocrystal Films	0:37	Iridescent Cellulose Nanocrystal Films Modified with Hydroxypropyl Cellulose.
32053370	1	26	theme	chiral	114:119	arg1	matrix					157:162	a chiral nematic cellulose nanocrystal (CNC) matrix	112:162	a chiral nematic cellulose nanocrystal (CNC) matrix	112:162	The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials.
32053370	5	27	theme	ten-fold	771:778	arg1	increase					780:787	a ten-fold increase	769:787	a ten-fold increase in elasticity	769:801	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	2	28	theme	hydroxypropyl	331:343	arg1	HPC					356:358	HPC	356:358	HPC	356:358	In this study, we explored the incorporation of hydroxypropyl cellulose (HPC) into a CNC film prepared by slow evaporation.
32053370	2	28	theme	hydroxypropyl	331:343	arg1	cellulose					345:353	hydroxypropyl cellulose	331:353	hydroxypropyl cellulose (HPC)	331:359	In this study, we explored the incorporation of hydroxypropyl cellulose (HPC) into a CNC film prepared by slow evaporation.
32053370	2	29	theme	slow	389:392	arg1	evaporation					394:404	slow evaporation	389:404	slow evaporation	389:404	In this study, we explored the incorporation of hydroxypropyl cellulose (HPC) into a CNC film prepared by slow evaporation.
32053370	3	30	theme	colored	557:563	arg1	film					565:568	a colored film	555:568	a colored film	555:568	In the composite CNC/HPC thin films, the CNCs adopt a chiral nematic structure, which can selectively reflect certain wavelengths of light to yield a colored film.
32053370	3	31	theme	thin	432:435	arg1	films					437:441	the composite CNC/HPC thin films	410:441	the composite CNC/HPC thin films	410:441	In the composite CNC/HPC thin films, the CNCs adopt a chiral nematic structure, which can selectively reflect certain wavelengths of light to yield a colored film.
32053370	6	32	mod	modification	909:920	arg3	Surface					901:907	Surface modification	901:920	Surface modification of the films with methacrylate groups	901:958	Surface modification of the films with methacrylate groups increased the hydrophobicity of the films, and therefore, the water stability of these materials was also improved.
32053370	6	32	mod	modification	909:920	arg1	films					929:933	the films	925:933	the films	925:933	Surface modification of the films with methacrylate groups increased the hydrophobicity of the films, and therefore, the water stability of these materials was also improved.
32053370	5	33	from	increase	780:787	arg1	strength					843:850	tensile strength	835:850	tensile strength	835:850	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	5	33	from	increase	780:787	arg1	stiffness					821:829	stiffness	821:829	stiffness	821:829	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	5	33	from	increase	780:787	arg1	elasticity					792:801	elasticity	792:801	elasticity	792:801	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	1	34	theme	properties	212:221	arg1	tuning					179:184	the tuning	175:184	the tuning of optical and mechanical properties	175:221	The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials.
32053370	5	35	theme	pure	743:746	arg1	films					752:756	pure CNC films	743:756	pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively	743:898	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	6	36	theme	water	1022:1026	arg1	stability					1028:1036	the water stability	1018:1036	the water stability of these materials	1018:1055	Surface modification of the films with methacrylate groups increased the hydrophobicity of the films, and therefore, the water stability of these materials was also improved.
32053370	1	37	theme	nematic	121:127	arg1	matrix					157:162	a chiral nematic cellulose nanocrystal (CNC) matrix	112:162	a chiral nematic cellulose nanocrystal (CNC) matrix	112:162	The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials.
32053370	0	38	theme	Hydroxypropyl	53:65	arg1	Cellulose					67:75	Hydroxypropyl Cellulose	53:75	Hydroxypropyl Cellulose	53:75	Iridescent Cellulose Nanocrystal Films Modified with Hydroxypropyl Cellulose.
32053370	1	39	theme	cellulose	129:137	arg1	matrix					157:162	a chiral nematic cellulose nanocrystal (CNC) matrix	112:162	a chiral nematic cellulose nanocrystal (CNC) matrix	112:162	The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials.
32053370	6	40	with	modification	909:920	arg1	groups					953:958	methacrylate groups	940:958	methacrylate groups	940:958	Surface modification of the films with methacrylate groups increased the hydrophobicity of the films, and therefore, the water stability of these materials was also improved.
32053370	1	41	theme	nanocrystal	139:149	arg1	matrix					157:162	a chiral nematic cellulose nanocrystal (CNC) matrix	112:162	a chiral nematic cellulose nanocrystal (CNC) matrix	112:162	The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials.
32053370	6	42	theme	materials	1047:1055	arg1	stability					1028:1036	the water stability	1018:1036	the water stability of these materials	1018:1055	Surface modification of the films with methacrylate groups increased the hydrophobicity of the films, and therefore, the water stability of these materials was also improved.
32053370	4	43	theme	HPC	681:683	arg1	concentration					640:652	the concentration	636:652	the concentration	636:652	The color could be tuned across the visible spectrum by changing the concentration or molecular weight of the HPC.
32053370	4	43	theme	HPC	681:683	arg1	weight					667:672	molecular weight	657:672	molecular weight	657:672	The color could be tuned across the visible spectrum by changing the concentration or molecular weight of the HPC.
32053370	5	44	theme	composite	703:711	arg1	films					713:717	the composite films	699:717	the composite films	699:717	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	5	44	theme	composite	703:711	arg1	flexible					729:736	flexible	729:736	flexible	729:736	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	5	45	from	decrease	809:816	arg1	strength					843:850	tensile strength	835:850	tensile strength	835:850	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	5	45	from	decrease	809:816	arg1	stiffness					821:829	stiffness	821:829	stiffness	821:829	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	5	45	from	decrease	809:816	arg1	elasticity					792:801	elasticity	792:801	elasticity	792:801	Importantly, the composite films were more flexible than pure CNC films with up to a ten-fold increase in elasticity and a decrease in stiffness and tensile strength of up to six times and four times, respectively.
32053370	1	46	theme	CNC	152:154	arg1	matrix					157:162	a chiral nematic cellulose nanocrystal (CNC) matrix	112:162	a chiral nematic cellulose nanocrystal (CNC) matrix	112:162	The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials.
32053370	4	47	theme	visible	607:613	arg1	spectrum					615:622	the visible spectrum	603:622	the visible spectrum	603:622	The color could be tuned across the visible spectrum by changing the concentration or molecular weight of the HPC.
32053370	3	48	theme	chiral	461:466	arg1	structure					476:484	a chiral nematic structure	459:484	a chiral nematic structure	459:484	In the composite CNC/HPC thin films, the CNCs adopt a chiral nematic structure, which can selectively reflect certain wavelengths of light to yield a colored film.
32053370	6	49	theme	films	929:933	arg1	modification					909:920	Surface modification	901:920	Surface modification of the films with methacrylate groups	901:958	Surface modification of the films with methacrylate groups increased the hydrophobicity of the films, and therefore, the water stability of these materials was also improved.
34411755	17	0	theme	material	2663:2670	arg1	feature					2681:2687	a key material property feature	2657:2687	a key material property feature of the remodeled cervix	2657:2711	Results show the significant swelling of cervical tissue, which evolves as pregnancy progresses, highlighting a key material property feature of the remodeled cervix.
34411755	6	1	theme	type	1110:1113	arg1	cervices					1121:1128	isolated wild type mouse cervices	1096:1128	isolated wild type mouse cervices	1096:1128	To investigate cervical swelling, osmotic loading tests are conducted on isolated wild type mouse cervices throughout pregnancy.
34411755	4	2	from	consequence	679:689	arg1	behavior					746:753	cervical structure-function behavior	718:753	cervical structure-function behavior	718:753	While GAGs have numerous physiological roles, the mechanical consequence of evolving GAG content on cervical structure-function behavior remains an open question.
34411755	1	3	theme	extra-cellular	251:264	arg1	ECM					274:276	ECM	274:276	ECM	274:276	The cervical remodeling process during pregnancy is characterized by progressive compositional and structural changes in the tissues extra-cellular matrix (ECM).
34411755	1	3	theme	extra-cellular	251:264	arg1	matrix					266:271	extra-cellular matrix	251:271	the tissues extra-cellular matrix (ECM)	239:277	The cervical remodeling process during pregnancy is characterized by progressive compositional and structural changes in the tissues extra-cellular matrix (ECM).
34411755	0	4	with	kinetics	52:59	arg1	osmolarity					66:75	osmolarity	66:75	osmolarity	66:75	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.
34411755	0	4	with	kinetics	52:59	arg1	role					85:88	the role	81:88	the role of hyaluronan in pregnancy	81:115	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.
34411755	8	5	with	strain	1291:1296	arg1	depletion					1311:1319	depletion	1311:1319	depletion of cervical HA	1311:1334	A genetically altered strain of mice with depletion of cervical HA is also tested to elucidate the contribution of HA to tissue swelling.
34411755	18	6	theme	HA	2751:2752	arg1	depletion					2754:2762	a cervical HA depletion	2740:2762	a cervical HA depletion	2740:2762	Using a mouse strain with a cervical HA depletion, this work shows HA contributes to the swelling trends of late-term cervical tissue, in a hypo-osmotic solution.
34411755	3	7	theme	GAG	536:538	arg1	hyaluronan					540:549	the non-sulfated GAG hyaluronan	519:549	especially the non-sulfated GAG hyaluronan (HA)	508:554	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA), is a fundamental change associated with cervical remodeling.
34411755	3	7	theme	GAG	536:538	arg1	pregnancy					497:505	pregnancy	497:505	pregnancy	497:505	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA), is a fundamental change associated with cervical remodeling.
34411755	3	7	theme	GAG	536:538	arg1	HA					552:553	HA	552:553	HA	552:553	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA), is a fundamental change associated with cervical remodeling.
34411755	16	8	theme	cervical	2450:2457	arg1	tissue					2459:2464	cervical tissue	2450:2464	cervical tissue	2450:2464	This study aims to measure the swelling kinetics of cervical tissue during pregnancy and to investigate the role of HA in these swelling tendencies.
34411755	17	9	theme	cervix	2706:2711	arg1	feature					2681:2687	a key material property feature	2657:2687	a key material property feature of the remodeled cervix	2657:2711	Results show the significant swelling of cervical tissue, which evolves as pregnancy progresses, highlighting a key material property feature of the remodeled cervix.
34411755	10	10	theme	media	1589:1593	arg1	osmolarity					1571:1580	osmolarity	1571:1580	osmolarity of the media	1571:1593	The swelling kinetics depend highly on osmolarity of the media and is altered with advancing pregnancy.
34411755	13	11	theme	extracellular	1930:1942	arg1	ECM					1952:1954	ECM	1952:1954	ECM	1952:1954	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM) undergoes drastic changes to fulfill the functional change of the cervix during pregnancy.
34411755	13	11	theme	extracellular	1930:1942	arg1	matrix					1944:1949	The cervical extracellular matrix	1917:1949	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM)	1890:1955	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM) undergoes drastic changes to fulfill the functional change of the cervix during pregnancy.
34411755	9	12	theme	volume	1466:1471	arg1	changes					1473:1479	volume changes	1466:1479	volume changes ranging from 20 to 100% after 3h of free swelling	1466:1529	Results show ex vivo cervical swelling is significant with volume changes ranging from 20 to 100% after 3h of free swelling.
34411755	18	13	from	trends	2812:2817	arg1	solution					2867:2874	a hypo-osmotic solution	2852:2874	a hypo-osmotic solution	2852:2874	Using a mouse strain with a cervical HA depletion, this work shows HA contributes to the swelling trends of late-term cervical tissue, in a hypo-osmotic solution.
34411755	11	14	theme	pregnancy	1763:1771	arg1	end					1756:1758	the end	1752:1758	the end of pregnancy	1752:1771	The contribution of HA to swelling is only significant in hypo-osmotic solution when HA cervical content is high at the end of pregnancy.
34411755	0	15	theme	hyaluronan	93:102	arg1	osmolarity					66:75	osmolarity	66:75	osmolarity	66:75	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.
34411755	0	15	theme	hyaluronan	93:102	arg1	role					85:88	the role	81:88	the role of hyaluronan in pregnancy	81:115	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.
34411755	2	16	theme	timed	294:298	arg1	remodeling					300:309	Appropriately timed remodeling	280:309	Appropriately timed remodeling	280:309	Appropriately timed remodeling is critical for healthy gestation and prevention of premature cervical softening leading to preterm birth (PTB).
34411755	1	17	theme	progressive	187:197	arg1	changes					228:234	progressive compositional and structural changes	187:234	progressive compositional and structural changes in the tissues extra-cellular matrix (ECM)	187:277	The cervical remodeling process during pregnancy is characterized by progressive compositional and structural changes in the tissues extra-cellular matrix (ECM).
34411755	11	18	from	end	1756:1758	arg1	high					1744:1747	high	1744:1747	high	1744:1747	The contribution of HA to swelling is only significant in hypo-osmotic solution when HA cervical content is high at the end of pregnancy.
34411755	9	19	dep	show	1415:1418	arg1	significant					1449:1459	significant	1449:1459	significant	1449:1459	Results show ex vivo cervical swelling is significant with volume changes ranging from 20 to 100% after 3h of free swelling.
34411755	4	20	theme	numerous	634:641	arg1	roles					657:661	numerous physiological roles	634:661	numerous physiological roles	634:661	While GAGs have numerous physiological roles, the mechanical consequence of evolving GAG content on cervical structure-function behavior remains an open question.
34411755	14	21	theme	clinical	2131:2138	arg1	challenge					2140:2148	a severe clinical challenge	2122:2148	a severe clinical challenge	2122:2148	Inappropriate timing for this transformation can result in preterm birth, a severe clinical challenge.
34411755	7	22	theme	various	1181:1187	arg1	solutions					1200:1208	various osmolarity solutions	1181:1208	various osmolarity solutions	1181:1208	These tests are performed in various osmolarity solutions to assess the influence of the media on swelling kinetics.
34411755	17	23	theme	significant	2564:2574	arg1	swelling					2576:2583	the significant swelling	2560:2583	the significant swelling	2560:2583	Results show the significant swelling of cervical tissue, which evolves as pregnancy progresses, highlighting a key material property feature of the remodeled cervix.
34411755	4	24	theme	content	707:713	arg1	consequence					679:689	the mechanical consequence	664:689	the mechanical consequence of evolving GAG content on cervical structure-function behavior	664:753	While GAGs have numerous physiological roles, the mechanical consequence of evolving GAG content on cervical structure-function behavior remains an open question.
34411755	3	25	theme	fundamental	562:572	arg1	change					574:579	a fundamental change	560:579	a fundamental change associated with cervical remodeling	560:615	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA), is a fundamental change associated with cervical remodeling.
34411755	3	25	theme	fundamental	562:572	arg1	Modification					424:435	Modification	424:435	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA),	424:555	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA), is a fundamental change associated with cervical remodeling.
34411755	5	26	theme	appropriate	909:919	arg1	definition					921:930	the appropriate definition	905:930	the appropriate definition of a reference configuration for mechanical tests	905:980	Additionally, an understanding of cervical swelling properties, postulated to be regulated in part by GAGs, is required for the appropriate definition of a reference configuration for mechanical tests and to enhance biological understanding.
34411755	0	27	from	role	85:88	arg1	pregnancy					107:115	pregnancy	107:115	pregnancy	107:115	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.
34411755	8	28	theme	cervical	1324:1331	arg1	HA					1333:1334	cervical HA	1324:1334	cervical HA	1324:1334	A genetically altered strain of mice with depletion of cervical HA is also tested to elucidate the contribution of HA to tissue swelling.
34411755	1	29	from	changes	228:234	arg1	tissues					243:249	the tissues extra-cellular matrix (ECM)	239:277	the tissues extra-cellular matrix (ECM)	239:277	The cervical remodeling process during pregnancy is characterized by progressive compositional and structural changes in the tissues extra-cellular matrix (ECM).
34411755	15	30	theme	ECM	2198:2200	arg1	changes					2174:2180	the fundamental changes	2158:2180	the fundamental changes of the cervical ECM	2158:2200	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	6	31	theme	cervical	1038:1045	arg1	swelling					1047:1054	cervical swelling	1038:1054	cervical swelling	1038:1054	To investigate cervical swelling, osmotic loading tests are conducted on isolated wild type mouse cervices throughout pregnancy.
34411755	17	32	theme	tissue	2597:2602	arg1	swelling					2576:2583	the significant swelling	2560:2583	the significant swelling	2560:2583	Results show the significant swelling of cervical tissue, which evolves as pregnancy progresses, highlighting a key material property feature of the remodeled cervix.
34411755	11	33	theme	cervical	1724:1731	arg1	content					1733:1739	HA cervical content	1721:1739	HA cervical content	1721:1739	The contribution of HA to swelling is only significant in hypo-osmotic solution when HA cervical content is high at the end of pregnancy.
34411755	7	34	theme	swelling	1250:1257	arg1	kinetics					1259:1266	swelling kinetics	1250:1266	swelling kinetics	1250:1266	These tests are performed in various osmolarity solutions to assess the influence of the media on swelling kinetics.
34411755	3	35	theme	cervical	597:604	arg1	remodeling					606:615	cervical remodeling	597:615	cervical remodeling	597:615	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA), is a fundamental change associated with cervical remodeling.
34411755	1	36	theme	cervical	122:129	arg1	process					142:148	The cervical remodeling process	118:148	The cervical remodeling process during pregnancy	118:165	The cervical remodeling process during pregnancy is characterized by progressive compositional and structural changes in the tissues extra-cellular matrix (ECM).
34411755	18	37	with	strain	2728:2733	arg1	depletion					2754:2762	a cervical HA depletion	2740:2762	a cervical HA depletion	2740:2762	Using a mouse strain with a cervical HA depletion, this work shows HA contributes to the swelling trends of late-term cervical tissue, in a hypo-osmotic solution.
34411755	4	38	theme	evolving	694:701	arg1	content					707:713	evolving GAG content	694:713	evolving GAG content	694:713	While GAGs have numerous physiological roles, the mechanical consequence of evolving GAG content on cervical structure-function behavior remains an open question.
34411755	7	39	theme	media	1241:1245	arg1	influence					1224:1232	the influence	1220:1232	the influence of the media on swelling kinetics	1220:1266	These tests are performed in various osmolarity solutions to assess the influence of the media on swelling kinetics.
34411755	18	40	theme	swelling	2803:2810	arg1	trends					2812:2817	the swelling trends	2799:2817	the swelling trends	2799:2817	Using a mouse strain with a cervical HA depletion, this work shows HA contributes to the swelling trends of late-term cervical tissue, in a hypo-osmotic solution.
34411755	1	41	dep	tissues	243:249	arg1	ECM					274:276	ECM	274:276	ECM	274:276	The cervical remodeling process during pregnancy is characterized by progressive compositional and structural changes in the tissues extra-cellular matrix (ECM).
34411755	1	41	dep	tissues	243:249	arg1	matrix					266:271	extra-cellular matrix	251:271	the tissues extra-cellular matrix (ECM)	239:277	The cervical remodeling process during pregnancy is characterized by progressive compositional and structural changes in the tissues extra-cellular matrix (ECM).
34411755	9	42	theme	swelling	1522:1529	arg1	3h					1511:1512	3h	1511:1512	3h of free swelling	1511:1529	Results show ex vivo cervical swelling is significant with volume changes ranging from 20 to 100% after 3h of free swelling.
34411755	14	43	theme	preterm	2107:2113	arg1	birth					2115:2119	preterm birth	2107:2119	preterm birth	2107:2119	Inappropriate timing for this transformation can result in preterm birth, a severe clinical challenge.
34411755	16	44	from	role	2506:2509	arg1	tendencies					2535:2544	these swelling tendencies	2520:2544	these swelling tendencies	2520:2544	This study aims to measure the swelling kinetics of cervical tissue during pregnancy and to investigate the role of HA in these swelling tendencies.
34411755	4	45	theme	cervical	718:725	arg1	behavior					746:753	cervical structure-function behavior	718:753	cervical structure-function behavior	718:753	While GAGs have numerous physiological roles, the mechanical consequence of evolving GAG content on cervical structure-function behavior remains an open question.
34411755	11	46	from	significant	1679:1689	arg1	solution					1707:1714	hypo-osmotic solution	1694:1714	hypo-osmotic solution	1694:1714	The contribution of HA to swelling is only significant in hypo-osmotic solution when HA cervical content is high at the end of pregnancy.
34411755	2	47	theme	preterm	403:409	arg1	PTB					418:420	PTB	418:420	PTB	418:420	Appropriately timed remodeling is critical for healthy gestation and prevention of premature cervical softening leading to preterm birth (PTB).
34411755	2	47	theme	preterm	403:409	arg1	birth					411:415	preterm birth	403:415	preterm birth (PTB)	403:421	Appropriately timed remodeling is critical for healthy gestation and prevention of premature cervical softening leading to preterm birth (PTB).
34411755	18	48	theme	cervical	2832:2839	arg1	tissue					2841:2846	late-term cervical tissue	2822:2846	late-term cervical tissue	2822:2846	Using a mouse strain with a cervical HA depletion, this work shows HA contributes to the swelling trends of late-term cervical tissue, in a hypo-osmotic solution.
34411755	16	49	theme	HA	2514:2515	arg1	role					2506:2509	the role	2502:2509	the role of HA in these swelling tendencies	2502:2544	This study aims to measure the swelling kinetics of cervical tissue during pregnancy and to investigate the role of HA in these swelling tendencies.
34411755	8	50	theme	HA	1384:1385	arg1	contribution					1368:1379	the contribution	1364:1379	the contribution of HA to tissue swelling	1364:1404	A genetically altered strain of mice with depletion of cervical HA is also tested to elucidate the contribution of HA to tissue swelling.
34411755	5	51	theme	swelling	824:831	arg1	properties					833:842	cervical swelling properties	815:842	cervical swelling properties	815:842	Additionally, an understanding of cervical swelling properties, postulated to be regulated in part by GAGs, is required for the appropriate definition of a reference configuration for mechanical tests and to enhance biological understanding.
34411755	5	52	theme	reference	937:945	arg1	configuration					947:959	a reference configuration	935:959	a reference configuration for mechanical tests	935:980	Additionally, an understanding of cervical swelling properties, postulated to be regulated in part by GAGs, is required for the appropriate definition of a reference configuration for mechanical tests and to enhance biological understanding.
34411755	18	53	theme	tissue	2841:2846	arg1	trends					2812:2817	the swelling trends	2799:2817	the swelling trends	2799:2817	Using a mouse strain with a cervical HA depletion, this work shows HA contributes to the swelling trends of late-term cervical tissue, in a hypo-osmotic solution.
34411755	8	54	theme	tissue	1390:1395	arg1	swelling					1397:1404	tissue swelling	1390:1404	tissue swelling	1390:1404	A genetically altered strain of mice with depletion of cervical HA is also tested to elucidate the contribution of HA to tissue swelling.
34411755	7	55	theme	osmolarity	1189:1198	arg1	solutions					1200:1208	various osmolarity solutions	1181:1208	various osmolarity solutions	1181:1208	These tests are performed in various osmolarity solutions to assess the influence of the media on swelling kinetics.
34411755	15	56	theme	glycosaminoglycan	2241:2257	arg1	content					2259:2265	the glycosaminoglycan content	2237:2265	the glycosaminoglycan content	2237:2265	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	15	56	theme	glycosaminoglycan	2241:2257	arg1	hyaluronan					2279:2288	hyaluronan	2279:2288	especially hyaluronan (HA)	2268:2293	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	12	57	theme	deformation	1825:1835	arg1	mechanisms					1837:1846	deformation mechanisms	1825:1846	deformation mechanisms	1825:1846	In summary, it is critical to account for swelling deformation mechanisms after excision in mechanical experiments.
34411755	6	58	theme	loading	1065:1071	arg1	tests					1073:1077	osmotic loading tests	1057:1077	osmotic loading tests	1057:1077	To investigate cervical swelling, osmotic loading tests are conducted on isolated wild type mouse cervices throughout pregnancy.
34411755	14	59	theme	Inappropriate	2048:2060	arg1	timing					2062:2067	Inappropriate timing	2048:2067	Inappropriate timing for this transformation	2048:2091	Inappropriate timing for this transformation can result in preterm birth, a severe clinical challenge.
34411755	3	60	theme	ECM	444:446	arg1	content					474:480	the ECM glycosaminoglycans (GAGs) content	440:480	the ECM glycosaminoglycans (GAGs) content	440:480	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA), is a fundamental change associated with cervical remodeling.
34411755	0	61	theme	Changing	43:50	arg1	kinetics					52:59	Changing kinetics	43:59	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.	0:116	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.
34411755	13	62	theme	functional	1998:2007	arg1	change					2009:2014	the functional change	1994:2014	the functional change of the cervix during pregnancy	1994:2045	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM) undergoes drastic changes to fulfill the functional change of the cervix during pregnancy.
34411755	0	63	theme	cervix	35:40	arg1	behavior					13:20	The swelling behavior	0:20	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.	0:116	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.
34411755	15	64	theme	significant	2209:2219	arg1	One					2151:2153	One	2151:2153	One	2151:2153	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	15	64	theme	significant	2209:2219	arg1	modification					2221:2232	the significant modification	2205:2232	the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix	2205:2395	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	15	64	theme	significant	2209:2219	arg1	changes					2174:2180	the fundamental changes	2158:2180	the fundamental changes of the cervical ECM	2158:2200	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	11	65	theme	HA	1721:1722	arg1	content					1733:1739	HA cervical content	1721:1739	HA cervical content	1721:1739	The contribution of HA to swelling is only significant in hypo-osmotic solution when HA cervical content is high at the end of pregnancy.
34411755	2	66	theme	healthy	327:333	arg1	gestation					335:343	healthy gestation and prevention	327:358	gestation	335:343	Appropriately timed remodeling is critical for healthy gestation and prevention of premature cervical softening leading to preterm birth (PTB).
34411755	1	67	theme	structural	217:226	arg1	changes					228:234	progressive compositional and structural changes	187:234	progressive compositional and structural changes in the tissues extra-cellular matrix (ECM)	187:277	The cervical remodeling process during pregnancy is characterized by progressive compositional and structural changes in the tissues extra-cellular matrix (ECM).
34411755	5	68	theme	biological	997:1006	arg1	understanding					1008:1020	biological understanding	997:1020	biological understanding	997:1020	Additionally, an understanding of cervical swelling properties, postulated to be regulated in part by GAGs, is required for the appropriate definition of a reference configuration for mechanical tests and to enhance biological understanding.
34411755	4	69	theme	mechanical	668:677	arg1	consequence					679:689	the mechanical consequence	664:689	the mechanical consequence of evolving GAG content on cervical structure-function behavior	664:753	While GAGs have numerous physiological roles, the mechanical consequence of evolving GAG content on cervical structure-function behavior remains an open question.
34411755	2	70	theme	cervical	373:380	arg1	softening					382:390	premature cervical softening	363:390	premature cervical softening leading to preterm birth (PTB)	363:421	Appropriately timed remodeling is critical for healthy gestation and prevention of premature cervical softening leading to preterm birth (PTB).
34411755	6	71	theme	mouse	1115:1119	arg1	cervices					1121:1128	isolated wild type mouse cervices	1096:1128	isolated wild type mouse cervices	1096:1128	To investigate cervical swelling, osmotic loading tests are conducted on isolated wild type mouse cervices throughout pregnancy.
34411755	9	72	theme	ex	1420:1421	arg1	swelling					1437:1444	ex vivo cervical swelling	1420:1444	ex vivo cervical swelling	1420:1444	Results show ex vivo cervical swelling is significant with volume changes ranging from 20 to 100% after 3h of free swelling.
34411755	16	73	theme	swelling	2429:2436	arg1	kinetics					2438:2445	the swelling kinetics	2425:2445	the swelling kinetics of cervical tissue	2425:2464	This study aims to measure the swelling kinetics of cervical tissue during pregnancy and to investigate the role of HA in these swelling tendencies.
34411755	17	74	theme	property	2672:2679	arg1	feature					2681:2687	a key material property feature	2657:2687	a key material property feature of the remodeled cervix	2657:2711	Results show the significant swelling of cervical tissue, which evolves as pregnancy progresses, highlighting a key material property feature of the remodeled cervix.
34411755	6	75	theme	wild	1105:1108	arg1	cervices					1121:1128	isolated wild type mouse cervices	1096:1128	isolated wild type mouse cervices	1096:1128	To investigate cervical swelling, osmotic loading tests are conducted on isolated wild type mouse cervices throughout pregnancy.
34411755	18	76	theme	cervical	2742:2749	arg1	depletion					2754:2762	a cervical HA depletion	2740:2762	a cervical HA depletion	2740:2762	Using a mouse strain with a cervical HA depletion, this work shows HA contributes to the swelling trends of late-term cervical tissue, in a hypo-osmotic solution.
34411755	18	77	theme	mouse	2722:2726	arg1	strain					2728:2733	a mouse strain	2720:2733	a mouse strain with a cervical HA depletion	2720:2762	Using a mouse strain with a cervical HA depletion, this work shows HA contributes to the swelling trends of late-term cervical tissue, in a hypo-osmotic solution.
34411755	9	78	theme	cervical	1428:1435	arg1	swelling					1437:1444	ex vivo cervical swelling	1420:1444	ex vivo cervical swelling	1420:1444	Results show ex vivo cervical swelling is significant with volume changes ranging from 20 to 100% after 3h of free swelling.
34411755	13	79	dep	STATEMENT	1890:1898	arg1	ECM					1952:1954	ECM	1952:1954	ECM	1952:1954	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM) undergoes drastic changes to fulfill the functional change of the cervix during pregnancy.
34411755	13	79	dep	STATEMENT	1890:1898	arg1	matrix					1944:1949	The cervical extracellular matrix	1917:1949	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM)	1890:1955	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM) undergoes drastic changes to fulfill the functional change of the cervix during pregnancy.
34411755	9	80	theme	free	1517:1520	arg1	swelling					1522:1529	free swelling	1517:1529	free swelling	1517:1529	Results show ex vivo cervical swelling is significant with volume changes ranging from 20 to 100% after 3h of free swelling.
34411755	3	81	theme	non-sulfated	523:534	arg1	hyaluronan					540:549	the non-sulfated GAG hyaluronan	519:549	especially the non-sulfated GAG hyaluronan (HA)	508:554	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA), is a fundamental change associated with cervical remodeling.
34411755	3	81	theme	non-sulfated	523:534	arg1	pregnancy					497:505	pregnancy	497:505	pregnancy	497:505	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA), is a fundamental change associated with cervical remodeling.
34411755	3	81	theme	non-sulfated	523:534	arg1	HA					552:553	HA	552:553	HA	552:553	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA), is a fundamental change associated with cervical remodeling.
34411755	16	82	theme	tissue	2459:2464	arg1	kinetics					2438:2445	the swelling kinetics	2425:2445	the swelling kinetics of cervical tissue	2425:2464	This study aims to measure the swelling kinetics of cervical tissue during pregnancy and to investigate the role of HA in these swelling tendencies.
34411755	17	83	theme	remodeled	2696:2704	arg1	cervix					2706:2711	the remodeled cervix	2692:2711	the remodeled cervix	2692:2711	Results show the significant swelling of cervical tissue, which evolves as pregnancy progresses, highlighting a key material property feature of the remodeled cervix.
34411755	4	84	theme	physiological	643:655	arg1	roles					657:661	numerous physiological roles	634:661	numerous physiological roles	634:661	While GAGs have numerous physiological roles, the mechanical consequence of evolving GAG content on cervical structure-function behavior remains an open question.
34411755	11	85	theme	HA	1656:1657	arg1	significant					1679:1689	significant	1679:1689	significant	1679:1689	The contribution of HA to swelling is only significant in hypo-osmotic solution when HA cervical content is high at the end of pregnancy.
34411755	11	85	theme	HA	1656:1657	arg1	contribution					1640:1651	The contribution	1636:1651	The contribution of HA to swelling	1636:1669	The contribution of HA to swelling is only significant in hypo-osmotic solution when HA cervical content is high at the end of pregnancy.
34411755	13	86	theme	cervical	1921:1928	arg1	ECM					1952:1954	ECM	1952:1954	ECM	1952:1954	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM) undergoes drastic changes to fulfill the functional change of the cervix during pregnancy.
34411755	13	86	theme	cervical	1921:1928	arg1	matrix					1944:1949	The cervical extracellular matrix	1917:1949	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM)	1890:1955	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM) undergoes drastic changes to fulfill the functional change of the cervix during pregnancy.
34411755	12	87	from	excision	1854:1861	arg1	experiments					1877:1887	mechanical experiments	1866:1887	mechanical experiments	1866:1887	In summary, it is critical to account for swelling deformation mechanisms after excision in mechanical experiments.
34411755	0	88	from	osmolarity	66:75	arg1	pregnancy					107:115	pregnancy	107:115	pregnancy	107:115	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.
34411755	15	89	theme	changes	2174:2180	arg1	One					2151:2153	One	2151:2153	One	2151:2153	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	15	89	theme	changes	2174:2180	arg1	changes					2174:2180	the fundamental changes	2158:2180	the fundamental changes of the cervical ECM	2158:2200	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	15	89	theme	changes	2174:2180	arg1	modification					2221:2232	the significant modification	2205:2232	the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix	2205:2395	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	8	90	theme	altered	1283:1289	arg1	strain					1291:1296	A genetically altered strain	1269:1296	A genetically altered strain of mice with depletion of cervical HA	1269:1334	A genetically altered strain of mice with depletion of cervical HA is also tested to elucidate the contribution of HA to tissue swelling.
34411755	15	91	theme	mechanical	2361:2370	arg1	properties					2372:2381	the swelling and mechanical properties	2344:2381	the swelling and mechanical properties of the cervix	2344:2395	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	1	92	theme	compositional	199:211	arg1	changes					228:234	progressive compositional and structural changes	187:234	progressive compositional and structural changes in the tissues extra-cellular matrix (ECM)	187:277	The cervical remodeling process during pregnancy is characterized by progressive compositional and structural changes in the tissues extra-cellular matrix (ECM).
34411755	7	93	from	influence	1224:1232	arg1	kinetics					1259:1266	swelling kinetics	1250:1266	swelling kinetics	1250:1266	These tests are performed in various osmolarity solutions to assess the influence of the media on swelling kinetics.
34411755	14	94	theme	severe	2124:2129	arg1	challenge					2140:2148	a severe clinical challenge	2122:2148	a severe clinical challenge	2122:2148	Inappropriate timing for this transformation can result in preterm birth, a severe clinical challenge.
34411755	15	95	theme	swelling	2348:2355	arg1	properties					2372:2381	the swelling and mechanical properties	2344:2381	the swelling and mechanical properties of the cervix	2344:2395	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	4	96	theme	GAG	703:705	arg1	content					707:713	evolving GAG content	694:713	evolving GAG content	694:713	While GAGs have numerous physiological roles, the mechanical consequence of evolving GAG content on cervical structure-function behavior remains an open question.
34411755	15	97	theme	cervical	2189:2196	arg1	ECM					2198:2200	the cervical ECM	2185:2200	the cervical ECM	2185:2200	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	17	98	theme	key	2659:2661	arg1	feature					2681:2687	a key material property feature	2657:2687	a key material property feature of the remodeled cervix	2657:2711	Results show the significant swelling of cervical tissue, which evolves as pregnancy progresses, highlighting a key material property feature of the remodeled cervix.
34411755	9	99	dep	ex	1420:1421	arg1	vivo					1423:1426	vivo	1423:1426	vivo	1423:1426	Results show ex vivo cervical swelling is significant with volume changes ranging from 20 to 100% after 3h of free swelling.
34411755	17	100	theme	cervical	2588:2595	arg1	tissue					2597:2602	cervical tissue	2588:2602	cervical tissue	2588:2602	Results show the significant swelling of cervical tissue, which evolves as pregnancy progresses, highlighting a key material property feature of the remodeled cervix.
34411755	13	101	theme	SIGNIFICANCE	1903:1914	arg1	STATEMENT					1890:1898	STATEMENT	1890:1898	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM)	1890:1955	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM) undergoes drastic changes to fulfill the functional change of the cervix during pregnancy.
34411755	16	102	theme	swelling	2526:2533	arg1	tendencies					2535:2544	these swelling tendencies	2520:2544	these swelling tendencies	2520:2544	This study aims to measure the swelling kinetics of cervical tissue during pregnancy and to investigate the role of HA in these swelling tendencies.
34411755	11	103	from	solution	1707:1714	arg1	significant					1679:1689	significant	1679:1689	significant	1679:1689	The contribution of HA to swelling is only significant in hypo-osmotic solution when HA cervical content is high at the end of pregnancy.
34411755	11	103	from	solution	1707:1714	arg1	contribution					1640:1651	The contribution	1636:1651	The contribution of HA to swelling	1636:1669	The contribution of HA to swelling is only significant in hypo-osmotic solution when HA cervical content is high at the end of pregnancy.
34411755	8	104	theme	HA	1333:1334	arg1	depletion					1311:1319	depletion	1311:1319	depletion of cervical HA	1311:1334	A genetically altered strain of mice with depletion of cervical HA is also tested to elucidate the contribution of HA to tissue swelling.
34411755	18	105	theme	hypo-osmotic	2854:2865	arg1	solution					2867:2874	a hypo-osmotic solution	2852:2874	a hypo-osmotic solution	2852:2874	Using a mouse strain with a cervical HA depletion, this work shows HA contributes to the swelling trends of late-term cervical tissue, in a hypo-osmotic solution.
34411755	1	106	theme	remodeling	131:140	arg1	process					142:148	The cervical remodeling process	118:148	The cervical remodeling process during pregnancy	118:165	The cervical remodeling process during pregnancy is characterized by progressive compositional and structural changes in the tissues extra-cellular matrix (ECM).
34411755	15	107	theme	fundamental	2162:2172	arg1	changes					2174:2180	the fundamental changes	2158:2180	the fundamental changes of the cervical ECM	2158:2200	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	0	108	dep	behavior	13:20	arg1	kinetics					52:59	Changing kinetics	43:59	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.	0:116	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.
34411755	5	109	theme	mechanical	965:974	arg1	tests					976:980	mechanical tests	965:980	mechanical tests	965:980	Additionally, an understanding of cervical swelling properties, postulated to be regulated in part by GAGs, is required for the appropriate definition of a reference configuration for mechanical tests and to enhance biological understanding.
34411755	4	110	theme	open	766:769	arg1	question					771:778	an open question	763:778	an open question	763:778	While GAGs have numerous physiological roles, the mechanical consequence of evolving GAG content on cervical structure-function behavior remains an open question.
34411755	13	111	theme	cervix	2023:2028	arg1	change					2009:2014	the functional change	1994:2014	the functional change of the cervix during pregnancy	1994:2045	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM) undergoes drastic changes to fulfill the functional change of the cervix during pregnancy.
34411755	12	112	theme	mechanical	1866:1875	arg1	experiments					1877:1887	mechanical experiments	1866:1887	mechanical experiments	1866:1887	In summary, it is critical to account for swelling deformation mechanisms after excision in mechanical experiments.
34411755	6	113	theme	isolated	1096:1103	arg1	cervices					1121:1128	isolated wild type mouse cervices	1096:1128	isolated wild type mouse cervices	1096:1128	To investigate cervical swelling, osmotic loading tests are conducted on isolated wild type mouse cervices throughout pregnancy.
34411755	9	114	dep	100	1500:1502	arg1	to					1497:1498	to	1497:1498	to	1497:1498	Results show ex vivo cervical swelling is significant with volume changes ranging from 20 to 100% after 3h of free swelling.
34411755	5	115	theme	cervical	815:822	arg1	properties					833:842	cervical swelling properties	815:842	cervical swelling properties	815:842	Additionally, an understanding of cervical swelling properties, postulated to be regulated in part by GAGs, is required for the appropriate definition of a reference configuration for mechanical tests and to enhance biological understanding.
34411755	18	116	theme	late-term	2822:2830	arg1	tissue					2841:2846	late-term cervical tissue	2822:2846	late-term cervical tissue	2822:2846	Using a mouse strain with a cervical HA depletion, this work shows HA contributes to the swelling trends of late-term cervical tissue, in a hypo-osmotic solution.
34411755	15	117	theme	cervix	2390:2395	arg1	properties					2372:2381	the swelling and mechanical properties	2344:2381	the swelling and mechanical properties of the cervix	2344:2395	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	17	118	theme	pregnancy	2622:2630	arg1	progresses					2632:2641	pregnancy progresses	2622:2641	pregnancy progresses	2622:2641	Results show the significant swelling of cervical tissue, which evolves as pregnancy progresses, highlighting a key material property feature of the remodeled cervix.
34411755	4	119	theme	structure-function	727:744	arg1	behavior					746:753	cervical structure-function behavior	718:753	cervical structure-function behavior	718:753	While GAGs have numerous physiological roles, the mechanical consequence of evolving GAG content on cervical structure-function behavior remains an open question.
34411755	2	120	theme	softening	382:390	arg1	gestation					335:343	healthy gestation and prevention	327:358	gestation	335:343	Appropriately timed remodeling is critical for healthy gestation and prevention of premature cervical softening leading to preterm birth (PTB).
34411755	2	120	theme	softening	382:390	arg1	prevention					349:358	healthy gestation and prevention	327:358	prevention	349:358	Appropriately timed remodeling is critical for healthy gestation and prevention of premature cervical softening leading to preterm birth (PTB).
34411755	5	121	theme	properties	833:842	arg1	understanding					798:810	an understanding	795:810	an understanding	795:810	Additionally, an understanding of cervical swelling properties, postulated to be regulated in part by GAGs, is required for the appropriate definition of a reference configuration for mechanical tests and to enhance biological understanding.
34411755	5	122	theme	configuration	947:959	arg1	definition					921:930	the appropriate definition	905:930	the appropriate definition of a reference configuration for mechanical tests	905:980	Additionally, an understanding of cervical swelling properties, postulated to be regulated in part by GAGs, is required for the appropriate definition of a reference configuration for mechanical tests and to enhance biological understanding.
34411755	4	123	contain	have	629:632	arg2	roles					657:661	numerous physiological roles	634:661	numerous physiological roles	634:661	While GAGs have numerous physiological roles, the mechanical consequence of evolving GAG content on cervical structure-function behavior remains an open question.
34411755	4	123	contain	have	629:632	arg1	GAGs					624:627	GAGs	624:627	GAGs	624:627	While GAGs have numerous physiological roles, the mechanical consequence of evolving GAG content on cervical structure-function behavior remains an open question.
34411755	0	124	theme	mouse	29:33	arg1	cervix					35:40	the mouse cervix	25:40	the mouse cervix	25:40	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.
34411755	15	125	theme	content	2259:2265	arg1	One					2151:2153	One	2151:2153	One	2151:2153	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	15	125	theme	content	2259:2265	arg1	modification					2221:2232	the significant modification	2205:2232	the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix	2205:2395	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	15	125	theme	content	2259:2265	arg1	changes					2174:2180	the fundamental changes	2158:2180	the fundamental changes of the cervical ECM	2158:2200	One of the fundamental changes of the cervical ECM is the significant modification of the glycosaminoglycan content, especially hyaluronan (HA), which is thought to contribute significantly to the swelling and mechanical properties of the cervix.
34411755	8	126	theme	mice	1301:1304	arg1	strain					1291:1296	A genetically altered strain	1269:1296	A genetically altered strain of mice with depletion of cervical HA	1269:1334	A genetically altered strain of mice with depletion of cervical HA is also tested to elucidate the contribution of HA to tissue swelling.
34411755	6	127	theme	osmotic	1057:1063	arg1	tests					1073:1077	osmotic loading tests	1057:1077	osmotic loading tests	1057:1077	To investigate cervical swelling, osmotic loading tests are conducted on isolated wild type mouse cervices throughout pregnancy.
34411755	3	128	theme	glycosaminoglycans	448:465	arg1	content					474:480	the ECM glycosaminoglycans (GAGs) content	440:480	the ECM glycosaminoglycans (GAGs) content	440:480	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA), is a fundamental change associated with cervical remodeling.
34411755	12	129	from	critical	1792:1799	arg1	summary					1777:1783	summary	1777:1783	summary	1777:1783	In summary, it is critical to account for swelling deformation mechanisms after excision in mechanical experiments.
34411755	2	130	theme	premature	363:371	arg1	softening					382:390	premature cervical softening	363:390	premature cervical softening leading to preterm birth (PTB)	363:421	Appropriately timed remodeling is critical for healthy gestation and prevention of premature cervical softening leading to preterm birth (PTB).
34411755	9	131	with	significant	1449:1459	arg1	changes					1473:1479	volume changes	1466:1479	volume changes ranging from 20 to 100% after 3h of free swelling	1466:1529	Results show ex vivo cervical swelling is significant with volume changes ranging from 20 to 100% after 3h of free swelling.
34411755	11	132	theme	hypo-osmotic	1694:1705	arg1	solution					1707:1714	hypo-osmotic solution	1694:1714	hypo-osmotic solution	1694:1714	The contribution of HA to swelling is only significant in hypo-osmotic solution when HA cervical content is high at the end of pregnancy.
34411755	13	133	theme	drastic	1967:1973	arg1	changes					1975:1981	drastic changes	1967:1981	drastic changes	1967:1981	STATEMENT OF SIGNIFICANCE: The cervical extracellular matrix (ECM) undergoes drastic changes to fulfill the functional change of the cervix during pregnancy.
34411755	3	134	theme	content	474:480	arg1	change					574:579	a fundamental change	560:579	a fundamental change associated with cervical remodeling	560:615	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA), is a fundamental change associated with cervical remodeling.
34411755	3	134	theme	content	474:480	arg1	Modification					424:435	Modification	424:435	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA),	424:555	Modification of the ECM glycosaminoglycans (GAGs) content with advancing pregnancy, especially the non-sulfated GAG hyaluronan (HA), is a fundamental change associated with cervical remodeling.
34411755	12	135	from	summary	1777:1783	arg1	critical					1792:1799	critical	1792:1799	critical	1792:1799	In summary, it is critical to account for swelling deformation mechanisms after excision in mechanical experiments.
34411755	10	136	theme	swelling	1536:1543	arg1	kinetics					1545:1552	The swelling kinetics	1532:1552	The swelling kinetics	1532:1552	The swelling kinetics depend highly on osmolarity of the media and is altered with advancing pregnancy.
34411755	0	137	theme	swelling	4:11	arg1	behavior					13:20	The swelling behavior	0:20	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.	0:116	The swelling behavior of the mouse cervix: Changing kinetics with osmolarity and the role of hyaluronan in pregnancy.
34445299	7	0	theme	clinical	1315:1322	arg1	applications					1324:1335	clinical applications	1315:1335	clinical applications in wound healing and skin regeneration	1315:1374	Results from this study indicate that crosslinked keratin-alginate sponges are suitable alternative dermal substitutes for clinical applications in wound healing and skin regeneration.
34445299	6	1	theme	more	1044:1047	arg1	wounds					1037:1042	the wounds	1033:1042	the wounds more than in collagen-treated wounds and non-grafted controls	1033:1104	Keratin-alginate composite sponges supported the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls, suggesting the subsequent development of pathological scar tissues may be minimized.
34445299	4	2	theme	human	625:629	arg1	fibroblasts					638:648	human dermal fibroblasts	625:648	human dermal fibroblasts	625:648	Keratin-alginate composite sponges supported the enhanced proliferation of human dermal fibroblasts compared to alginate-only sponges and exhibited decreased contraction in vitro when compared to keratin only sponges.
34445299	6	3	theme	composite	963:971	arg1	sponges					973:979	Keratin-alginate composite sponges	946:979	Keratin-alginate composite sponges	946:979	Keratin-alginate composite sponges supported the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls, suggesting the subsequent development of pathological scar tissues may be minimized.
34445299	3	4	dep	ability	405:411	arg1	support					465:471	support	465:471	to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs	462:547	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	3	4	dep	ability	405:411	arg1	support					416:422	support	416:422	to support human dermal fibroblasts in vitro	413:456	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	3	5	theme	Sus	533:535	arg1	pigs					544:547	Sus scrofa pigs	533:547	Sus scrofa pigs	533:547	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	3	6	dep	closure	477:483	arg1	the					473:475	the	473:475	the	473:475	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	1	7	theme	Deep	69:72	arg1	damage					98:103	Deep partial-thickness burns damage	69:103	Deep partial-thickness burns damage	69:103	Deep partial-thickness burns damage most of the dermis and can cause severe pain, scarring, and mortality if left untreated.
34445299	4	8	theme	fibroblasts	638:648	arg1	proliferation					608:620	the enhanced proliferation	595:620	the enhanced proliferation of human dermal fibroblasts	595:648	Keratin-alginate composite sponges supported the enhanced proliferation of human dermal fibroblasts compared to alginate-only sponges and exhibited decreased contraction in vitro when compared to keratin only sponges.
34445299	6	9	theme	Keratin-alginate	946:961	arg1	sponges					973:979	Keratin-alginate composite sponges	946:979	Keratin-alginate composite sponges	946:979	Keratin-alginate composite sponges supported the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls, suggesting the subsequent development of pathological scar tissues may be minimized.
34445299	1	10	theme	partial-thickness	74:90	arg1	damage					98:103	Deep partial-thickness burns damage	69:103	Deep partial-thickness burns damage	69:103	Deep partial-thickness burns damage most of the dermis and can cause severe pain, scarring, and mortality if left untreated.
34445299	2	11	link	crosslinked	245:255	arg1	sponges					284:290	crosslinked keratin-alginate composite sponges	245:290	crosslinked keratin-alginate composite sponges	245:290	This study serves to evaluate the effectiveness of crosslinked keratin-alginate composite sponges as dermal substitutes for deep partial-thickness burns.
34445299	6	12	theme	scar	1161:1164	arg1	tissues					1166:1172	pathological scar tissues	1148:1172	pathological scar tissues	1148:1172	Keratin-alginate composite sponges supported the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls, suggesting the subsequent development of pathological scar tissues may be minimized.
34445299	1	13	theme	burns	92:96	arg1	damage					98:103	Deep partial-thickness burns damage	69:103	Deep partial-thickness burns damage	69:103	Deep partial-thickness burns damage most of the dermis and can cause severe pain, scarring, and mortality if left untreated.
34445299	5	14	theme	wound	901:905	arg1	sites					907:911	wound sites	901:911	wound sites	901:911	As dermal substitutes in vivo, the sponges supported the expression of keratin 14, alpha-smooth muscle actin, and collagen IV within wound sites, comparable to collagen sponges.
34445299	0	15	theme	Burns	62:66	arg1	Healing					33:39	Healing	33:39	Healing of Partial-Thickness Burns	33:66	Keratin-Alginate Sponges Support Healing of Partial-Thickness Burns.
34445299	6	16	theme	collagen-treated	1057:1072	arg1	wounds					1074:1079	collagen-treated wounds	1057:1079	collagen-treated wounds	1057:1079	Keratin-alginate composite sponges supported the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls, suggesting the subsequent development of pathological scar tissues may be minimized.
34445299	2	17	theme	composite	274:282	arg1	sponges					284:290	crosslinked keratin-alginate composite sponges	245:290	crosslinked keratin-alginate composite sponges	245:290	This study serves to evaluate the effectiveness of crosslinked keratin-alginate composite sponges as dermal substitutes for deep partial-thickness burns.
34445299	6	18	theme	tissues	1166:1172	arg1	development					1133:1143	the subsequent development	1118:1143	the subsequent development of pathological scar tissues	1118:1172	Keratin-alginate composite sponges supported the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls, suggesting the subsequent development of pathological scar tissues may be minimized.
34445299	6	19	theme	pathological	1148:1159	arg1	tissues					1166:1172	pathological scar tissues	1148:1172	pathological scar tissues	1148:1172	Keratin-alginate composite sponges supported the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls, suggesting the subsequent development of pathological scar tissues may be minimized.
34445299	5	20	theme	alpha-smooth	851:862	arg1	actin					871:875	alpha-smooth muscle actin	851:875	alpha-smooth muscle actin	851:875	As dermal substitutes in vivo, the sponges supported the expression of keratin 14, alpha-smooth muscle actin, and collagen IV within wound sites, comparable to collagen sponges.
34445299	6	21	theme	membranes	1020:1028	arg1	regeneration					995:1006	the regeneration	991:1006	the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls	991:1104	Keratin-alginate composite sponges supported the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls, suggesting the subsequent development of pathological scar tissues may be minimized.
34445299	5	22	dep	dermal	771:776	arg1	substitutes					778:788	substitutes	778:788	substitutes	778:788	As dermal substitutes in vivo, the sponges supported the expression of keratin 14, alpha-smooth muscle actin, and collagen IV within wound sites, comparable to collagen sponges.
34445299	2	23	theme	partial-thickness	323:339	arg1	burns					341:345	deep partial-thickness burns	318:345	deep partial-thickness burns	318:345	This study serves to evaluate the effectiveness of crosslinked keratin-alginate composite sponges as dermal substitutes for deep partial-thickness burns.
34445299	0	24	theme	Keratin-Alginate	0:15	arg1	Sponges					17:23	Keratin-Alginate Sponges	0:23	Keratin-Alginate Sponges	0:23	Keratin-Alginate Sponges Support Healing of Partial-Thickness Burns.
34445299	2	25	theme	deep	318:321	arg1	burns					341:345	deep partial-thickness burns	318:345	deep partial-thickness burns	318:345	This study serves to evaluate the effectiveness of crosslinked keratin-alginate composite sponges as dermal substitutes for deep partial-thickness burns.
34445299	5	26	theme	comparable	914:923	arg1	sites					907:911	wound sites	901:911	wound sites	901:911	As dermal substitutes in vivo, the sponges supported the expression of keratin 14, alpha-smooth muscle actin, and collagen IV within wound sites, comparable to collagen sponges.
34445299	5	27	theme	actin	871:875	arg1	expression					825:834	the expression	821:834	the expression of keratin 14, alpha-smooth muscle actin, and collagen IV within wound sites, comparable to collagen sponges	821:943	As dermal substitutes in vivo, the sponges supported the expression of keratin 14, alpha-smooth muscle actin, and collagen IV within wound sites, comparable to collagen sponges.
34445299	5	28	theme	muscle	864:869	arg1	actin					871:875	alpha-smooth muscle actin	851:875	alpha-smooth muscle actin	851:875	As dermal substitutes in vivo, the sponges supported the expression of keratin 14, alpha-smooth muscle actin, and collagen IV within wound sites, comparable to collagen sponges.
34445299	3	29	link	Crosslinked	348:358	arg1	sponges					377:383	Crosslinked keratin-alginate sponges	348:383	Crosslinked keratin-alginate sponges	348:383	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	6	30	theme	subsequent	1122:1131	arg1	development					1133:1143	the subsequent development	1118:1143	the subsequent development of pathological scar tissues	1118:1172	Keratin-alginate composite sponges supported the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls, suggesting the subsequent development of pathological scar tissues may be minimized.
34445299	2	31	theme	sponges	284:290	arg1	effectiveness					228:240	the effectiveness	224:240	the effectiveness of crosslinked keratin-alginate composite sponges	224:290	This study serves to evaluate the effectiveness of crosslinked keratin-alginate composite sponges as dermal substitutes for deep partial-thickness burns.
34445299	4	32	theme	only	754:757	arg1	sponges					759:765	keratin only sponges	746:765	keratin only sponges	746:765	Keratin-alginate composite sponges supported the enhanced proliferation of human dermal fibroblasts compared to alginate-only sponges and exhibited decreased contraction in vitro when compared to keratin only sponges.
34445299	5	33	theme	collagen	882:889	arg1	expression					825:834	the expression	821:834	the expression of keratin 14, alpha-smooth muscle actin, and collagen IV within wound sites, comparable to collagen sponges	821:943	As dermal substitutes in vivo, the sponges supported the expression of keratin 14, alpha-smooth muscle actin, and collagen IV within wound sites, comparable to collagen sponges.
34445299	0	34	theme	Partial-Thickness	44:60	arg1	Burns					62:66	Partial-Thickness Burns	44:66	Partial-Thickness Burns	44:66	Keratin-Alginate Sponges Support Healing of Partial-Thickness Burns.
34445299	4	35	theme	enhanced	599:606	arg1	proliferation					608:620	the enhanced proliferation	595:620	the enhanced proliferation of human dermal fibroblasts	595:648	Keratin-alginate composite sponges supported the enhanced proliferation of human dermal fibroblasts compared to alginate-only sponges and exhibited decreased contraction in vitro when compared to keratin only sponges.
34445299	7	36	theme	skin	1358:1361	arg1	regeneration					1363:1374	skin regeneration	1358:1374	skin regeneration	1358:1374	Results from this study indicate that crosslinked keratin-alginate sponges are suitable alternative dermal substitutes for clinical applications in wound healing and skin regeneration.
34445299	5	37	theme	keratin	839:845	arg1	expression					825:834	the expression	821:834	the expression of keratin 14, alpha-smooth muscle actin, and collagen IV within wound sites, comparable to collagen sponges	821:943	As dermal substitutes in vivo, the sponges supported the expression of keratin 14, alpha-smooth muscle actin, and collagen IV within wound sites, comparable to collagen sponges.
34445299	4	38	theme	Keratin-alginate	550:565	arg1	sponges					577:583	Keratin-alginate composite sponges	550:583	Keratin-alginate composite sponges	550:583	Keratin-alginate composite sponges supported the enhanced proliferation of human dermal fibroblasts compared to alginate-only sponges and exhibited decreased contraction in vitro when compared to keratin only sponges.
34445299	7	39	theme	crosslinked	1230:1240	arg1	sponges					1259:1265	crosslinked keratin-alginate sponges	1230:1265	crosslinked keratin-alginate sponges	1230:1265	Results from this study indicate that crosslinked keratin-alginate sponges are suitable alternative dermal substitutes for clinical applications in wound healing and skin regeneration.
34445299	7	40	theme	keratin-alginate	1242:1257	arg1	sponges					1259:1265	crosslinked keratin-alginate sponges	1230:1265	crosslinked keratin-alginate sponges	1230:1265	Results from this study indicate that crosslinked keratin-alginate sponges are suitable alternative dermal substitutes for clinical applications in wound healing and skin regeneration.
34445299	4	41	theme	decreased	698:706	arg1	contraction					708:718	decreased contraction	698:718	decreased contraction	698:718	Keratin-alginate composite sponges supported the enhanced proliferation of human dermal fibroblasts compared to alginate-only sponges and exhibited decreased contraction in vitro when compared to keratin only sponges.
34445299	3	42	theme	human	424:428	arg1	fibroblasts					437:447	human dermal fibroblasts	424:447	human dermal fibroblasts	424:447	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	6	43	theme	basement	1011:1018	arg1	membranes					1020:1028	basement membranes	1011:1028	basement membranes	1011:1028	Keratin-alginate composite sponges supported the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls, suggesting the subsequent development of pathological scar tissues may be minimized.
34445299	6	44	from	regeneration	995:1006	arg1	wounds					1037:1042	the wounds	1033:1042	the wounds more than in collagen-treated wounds and non-grafted controls	1033:1104	Keratin-alginate composite sponges supported the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls, suggesting the subsequent development of pathological scar tissues may be minimized.
34445299	7	45	theme	wound	1340:1344	arg1	healing					1346:1352	wound healing	1340:1352	wound healing	1340:1352	Results from this study indicate that crosslinked keratin-alginate sponges are suitable alternative dermal substitutes for clinical applications in wound healing and skin regeneration.
34445299	3	46	from	closure	477:483	arg1	pigs					544:547	Sus scrofa pigs	533:547	Sus scrofa pigs	533:547	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	3	47	theme	burn	518:521	arg1	wounds					523:528	partial-thickness burn wounds	500:528	partial-thickness burn wounds	500:528	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	3	48	theme	dermal	430:435	arg1	fibroblasts					437:447	human dermal fibroblasts	424:447	human dermal fibroblasts	424:447	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	7	49	link	crosslinked	1230:1240	arg1	sponges					1259:1265	crosslinked keratin-alginate sponges	1230:1265	crosslinked keratin-alginate sponges	1230:1265	Results from this study indicate that crosslinked keratin-alginate sponges are suitable alternative dermal substitutes for clinical applications in wound healing and skin regeneration.
34445299	3	50	theme	wounds	523:528	arg1	closure					477:483	closure	477:483	closure	477:483	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	3	50	theme	wounds	523:528	arg1	healing					489:495	healing	489:495	healing	489:495	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	4	51	theme	composite	567:575	arg1	sponges					577:583	Keratin-alginate composite sponges	550:583	Keratin-alginate composite sponges	550:583	Keratin-alginate composite sponges supported the enhanced proliferation of human dermal fibroblasts compared to alginate-only sponges and exhibited decreased contraction in vitro when compared to keratin only sponges.
34445299	7	52	from	applications	1324:1335	arg1	healing					1346:1352	wound healing	1340:1352	wound healing	1340:1352	Results from this study indicate that crosslinked keratin-alginate sponges are suitable alternative dermal substitutes for clinical applications in wound healing and skin regeneration.
34445299	7	52	from	applications	1324:1335	arg1	regeneration					1363:1374	skin regeneration	1358:1374	skin regeneration	1358:1374	Results from this study indicate that crosslinked keratin-alginate sponges are suitable alternative dermal substitutes for clinical applications in wound healing and skin regeneration.
34445299	2	53	theme	keratin-alginate	257:272	arg1	sponges					284:290	crosslinked keratin-alginate composite sponges	245:290	crosslinked keratin-alginate composite sponges	245:290	This study serves to evaluate the effectiveness of crosslinked keratin-alginate composite sponges as dermal substitutes for deep partial-thickness burns.
34445299	3	54	from	healing	489:495	arg1	pigs					544:547	Sus scrofa pigs	533:547	Sus scrofa pigs	533:547	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	2	55	theme	crosslinked	245:255	arg1	sponges					284:290	crosslinked keratin-alginate composite sponges	245:290	crosslinked keratin-alginate composite sponges	245:290	This study serves to evaluate the effectiveness of crosslinked keratin-alginate composite sponges as dermal substitutes for deep partial-thickness burns.
34445299	1	56	theme	severe	138:143	arg1	pain					145:148	pain	145:148	pain	145:148	Deep partial-thickness burns damage most of the dermis and can cause severe pain, scarring, and mortality if left untreated.
34445299	6	57	theme	non-grafted	1085:1095	arg1	controls					1097:1104	non-grafted controls	1085:1104	non-grafted controls	1085:1104	Keratin-alginate composite sponges supported the regeneration of basement membranes in the wounds more than in collagen-treated wounds and non-grafted controls, suggesting the subsequent development of pathological scar tissues may be minimized.
34445299	3	58	theme	Crosslinked	348:358	arg1	sponges					377:383	Crosslinked keratin-alginate sponges	348:383	Crosslinked keratin-alginate sponges	348:383	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	4	59	theme	keratin	746:752	arg1	sponges					759:765	keratin only sponges	746:765	keratin only sponges	746:765	Keratin-alginate composite sponges supported the enhanced proliferation of human dermal fibroblasts compared to alginate-only sponges and exhibited decreased contraction in vitro when compared to keratin only sponges.
34445299	3	60	theme	partial-thickness	500:516	arg1	wounds					523:528	partial-thickness burn wounds	500:528	partial-thickness burn wounds	500:528	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	4	61	theme	dermal	631:636	arg1	fibroblasts					638:648	human dermal fibroblasts	625:648	human dermal fibroblasts	625:648	Keratin-alginate composite sponges supported the enhanced proliferation of human dermal fibroblasts compared to alginate-only sponges and exhibited decreased contraction in vitro when compared to keratin only sponges.
34445299	3	62	theme	keratin-alginate	360:375	arg1	sponges					377:383	Crosslinked keratin-alginate sponges	348:383	Crosslinked keratin-alginate sponges	348:383	Crosslinked keratin-alginate sponges were tested for the ability to support human dermal fibroblasts in vitro and to support the closure and healing of partial-thickness burn wounds in Sus scrofa pigs.
34445299	7	63	from	study	1210:1214	arg1	Results					1192:1198	Results	1192:1198	Results from this study	1192:1214	Results from this study indicate that crosslinked keratin-alginate sponges are suitable alternative dermal substitutes for clinical applications in wound healing and skin regeneration.
34445299	5	64	theme	collagen	928:935	arg1	sponges					937:943	collagen sponges	928:943	collagen sponges	928:943	As dermal substitutes in vivo, the sponges supported the expression of keratin 14, alpha-smooth muscle actin, and collagen IV within wound sites, comparable to collagen sponges.
34445299	4	65	theme	alginate-only	662:674	arg1	sponges					676:682	alginate-only sponges	662:682	alginate-only sponges	662:682	Keratin-alginate composite sponges supported the enhanced proliferation of human dermal fibroblasts compared to alginate-only sponges and exhibited decreased contraction in vitro when compared to keratin only sponges.
33431680	6	0	theme	3D-printable	792:803	arg1	polymer					805:811	a 3D-printable polymer	790:811	a 3D-printable polymer that allows for an additional cross-linking reaction with photosynthesis-produced glucose in the material bulk or on the interface	790:942	The mechanism relies on a 3D-printable polymer that allows for an additional cross-linking reaction with photosynthesis-produced glucose in the material bulk or on the interface.
33431680	8	1	theme	soft	1231:1234	arg1	robotics					1236:1243	soft robotics	1231:1243	soft robotics	1231:1243	This work opens the door for the design of hybrid synthetic-living materials, for applications such as smart composites, lightweight structures, and soft robotics.
33431680	3	2	theme	photosynthesis-produced	405:427	arg1	glucose					429:435	photosynthesis-produced glucose	405:435	photosynthesis-produced glucose	405:435	For example, plants strengthen their cell structures by transforming photosynthesis-produced glucose into stiff polysaccharides.
33431680	6	3	theme	photosynthesis-produced	871:893	arg1	glucose					895:901	photosynthesis-produced glucose	871:901	photosynthesis-produced glucose	871:901	The mechanism relies on a 3D-printable polymer that allows for an additional cross-linking reaction with photosynthesis-produced glucose in the material bulk or on the interface.
33431680	7	4	theme	environmental	1062:1074	arg1	cues					1076:1079	environmental cues	1062:1079	environmental cues	1062:1079	The remodeling behavior can be suspended by freezing chloroplasts, regulated by mechanical preloads, and reversed by environmental cues.
33431680	6	5	theme	material	910:917	arg1	bulk					919:922	the material bulk	906:922	the material bulk	906:922	The mechanism relies on a 3D-printable polymer that allows for an additional cross-linking reaction with photosynthesis-produced glucose in the material bulk or on the interface.
33431680	1	6	theme	mechanical	80:89	arg1	properties					91:100	The mechanical properties	76:100	The mechanical properties of engineering structures	76:126	The mechanical properties of engineering structures continuously weaken during service life because of material fatigue or degradation.
33431680	4	7	theme	chloroplasts	543:554	arg1	photosynthesis					516:529	photosynthesis	516:529	photosynthesis of embedded chloroplasts	516:554	In this work, we realize hybrid materials that use photosynthesis of embedded chloroplasts to remodel their microstructures.
33431680	6	8	theme	additional	832:841	arg1	reaction					857:864	an additional cross-linking reaction	829:864	an additional cross-linking reaction with photosynthesis-produced glucose in the material bulk or on the interface	829:942	The mechanism relies on a 3D-printable polymer that allows for an additional cross-linking reaction with photosynthesis-produced glucose in the material bulk or on the interface.
33431680	2	9	theme	structures	324:333	arg1	parts					309:313	parts	309:313	parts of their structures	309:333	By contrast, living organisms are able to strengthen their mechanical properties by regenerating parts of their structures.
33431680	7	10	theme	remodeling	949:958	arg1	behavior					960:967	The remodeling behavior	945:967	The remodeling behavior	945:967	The remodeling behavior can be suspended by freezing chloroplasts, regulated by mechanical preloads, and reversed by environmental cues.
33431680	4	11	theme	embedded	534:541	arg1	chloroplasts					543:554	embedded chloroplasts	534:554	embedded chloroplasts	534:554	In this work, we realize hybrid materials that use photosynthesis of embedded chloroplasts to remodel their microstructures.
33431680	8	12	theme	materials	1149:1157	arg1	design					1115:1120	the design	1111:1120	the design of hybrid synthetic-living materials	1111:1157	This work opens the door for the design of hybrid synthetic-living materials, for applications such as smart composites, lightweight structures, and soft robotics.
33431680	8	13	theme	synthetic-living	1132:1147	arg1	materials					1149:1157	hybrid synthetic-living materials	1125:1157	hybrid synthetic-living materials	1125:1157	This work opens the door for the design of hybrid synthetic-living materials, for applications such as smart composites, lightweight structures, and soft robotics.
33431680	1	14	theme	engineering	105:115	arg1	structures					117:126	engineering structures	105:126	engineering structures	105:126	The mechanical properties of engineering structures continuously weaken during service life because of material fatigue or degradation.
33431680	5	15	theme	-print	645:650	arg1	structures					663:672	three-dimensionally (3D)-print functional structures	621:672	three-dimensionally (3D)-print functional structures	621:672	These materials can be used to three-dimensionally (3D)-print functional structures, which are endowed with matrix-strengthening and crack healing when exposed to white light.
33431680	1	16	theme	structures	117:126	arg1	properties					91:100	The mechanical properties	76:100	The mechanical properties of engineering structures	76:126	The mechanical properties of engineering structures continuously weaken during service life because of material fatigue or degradation.
33431680	0	17	theme	Photosynthesis-assisted	0:22	arg1	remodeling					24:33	Photosynthesis-assisted remodeling	0:33	Photosynthesis-assisted remodeling of three-dimensional printed structures	0:73	Photosynthesis-assisted remodeling of three-dimensional printed structures.
33431680	5	18	theme	crack	723:727	arg1	healing					729:735	crack healing	723:735	crack healing	723:735	These materials can be used to three-dimensionally (3D)-print functional structures, which are endowed with matrix-strengthening and crack healing when exposed to white light.
33431680	5	19	theme	functional	652:661	arg1	structures					663:672	three-dimensionally (3D)-print functional structures	621:672	three-dimensionally (3D)-print functional structures	621:672	These materials can be used to three-dimensionally (3D)-print functional structures, which are endowed with matrix-strengthening and crack healing when exposed to white light.
33431680	0	20	theme	three-dimensional	38:54	arg1	structures					64:73	three-dimensional printed structures	38:73	three-dimensional printed structures	38:73	Photosynthesis-assisted remodeling of three-dimensional printed structures.
33431680	7	21	theme	mechanical	1025:1034	arg1	preloads					1036:1043	mechanical preloads	1025:1043	mechanical preloads	1025:1043	The remodeling behavior can be suspended by freezing chloroplasts, regulated by mechanical preloads, and reversed by environmental cues.
33431680	1	22	dep	material	179:186	arg1	fatigue					188:194	fatigue	188:194	fatigue	188:194	The mechanical properties of engineering structures continuously weaken during service life because of material fatigue or degradation.
33431680	3	23	theme	stiff	442:446	arg1	polysaccharides					448:462	stiff polysaccharides	442:462	stiff polysaccharides	442:462	For example, plants strengthen their cell structures by transforming photosynthesis-produced glucose into stiff polysaccharides.
33431680	6	24	from	reaction	857:864	arg1	interface					934:942	the interface	930:942	the interface	930:942	The mechanism relies on a 3D-printable polymer that allows for an additional cross-linking reaction with photosynthesis-produced glucose in the material bulk or on the interface.
33431680	6	24	from	reaction	857:864	arg1	bulk					919:922	the material bulk	906:922	the material bulk	906:922	The mechanism relies on a 3D-printable polymer that allows for an additional cross-linking reaction with photosynthesis-produced glucose in the material bulk or on the interface.
33431680	0	25	theme	structures	64:73	arg1	remodeling					24:33	Photosynthesis-assisted remodeling	0:33	Photosynthesis-assisted remodeling of three-dimensional printed structures	0:73	Photosynthesis-assisted remodeling of three-dimensional printed structures.
33431680	8	26	theme	smart	1185:1189	arg1	composites					1191:1200	smart composites	1185:1200	smart composites	1185:1200	This work opens the door for the design of hybrid synthetic-living materials, for applications such as smart composites, lightweight structures, and soft robotics.
33431680	2	27	theme	mechanical	271:280	arg1	properties					282:291	their mechanical properties	265:291	their mechanical properties	265:291	By contrast, living organisms are able to strengthen their mechanical properties by regenerating parts of their structures.
33431680	0	28	theme	printed	56:62	arg1	structures					64:73	three-dimensional printed structures	38:73	three-dimensional printed structures	38:73	Photosynthesis-assisted remodeling of three-dimensional printed structures.
33431680	6	29	with	reaction	857:864	arg1	glucose					895:901	photosynthesis-produced glucose	871:901	photosynthesis-produced glucose	871:901	The mechanism relies on a 3D-printable polymer that allows for an additional cross-linking reaction with photosynthesis-produced glucose in the material bulk or on the interface.
33431680	6	30	theme	cross-linking	843:855	arg1	reaction					857:864	an additional cross-linking reaction	829:864	an additional cross-linking reaction with photosynthesis-produced glucose in the material bulk or on the interface	829:942	The mechanism relies on a 3D-printable polymer that allows for an additional cross-linking reaction with photosynthesis-produced glucose in the material bulk or on the interface.
33431680	5	31	with	endowed	685:691	arg1	matrix-strengthening					698:717	matrix-strengthening	698:717	matrix-strengthening	698:717	These materials can be used to three-dimensionally (3D)-print functional structures, which are endowed with matrix-strengthening and crack healing when exposed to white light.
33431680	5	31	with	endowed	685:691	arg1	healing					729:735	crack healing	723:735	crack healing	723:735	These materials can be used to three-dimensionally (3D)-print functional structures, which are endowed with matrix-strengthening and crack healing when exposed to white light.
33431680	5	32	theme	white	753:757	arg1	light					759:763	white light	753:763	white light	753:763	These materials can be used to three-dimensionally (3D)-print functional structures, which are endowed with matrix-strengthening and crack healing when exposed to white light.
33431680	5	33	theme	three-dimensionally	621:639	arg1	structures					663:672	three-dimensionally (3D)-print functional structures	621:672	three-dimensionally (3D)-print functional structures	621:672	These materials can be used to three-dimensionally (3D)-print functional structures, which are endowed with matrix-strengthening and crack healing when exposed to white light.
33431680	1	34	theme	service	155:161	arg1	life					163:166	service life	155:166	service life	155:166	The mechanical properties of engineering structures continuously weaken during service life because of material fatigue or degradation.
33431680	8	35	theme	hybrid	1125:1130	arg1	materials					1149:1157	hybrid synthetic-living materials	1125:1157	hybrid synthetic-living materials	1125:1157	This work opens the door for the design of hybrid synthetic-living materials, for applications such as smart composites, lightweight structures, and soft robotics.
33431680	5	36	used	used	613:616	arg2	materials					596:604	These materials	590:604	These materials	590:604	These materials can be used to three-dimensionally (3D)-print functional structures, which are endowed with matrix-strengthening and crack healing when exposed to white light.
33431680	5	37	theme	3D	642:643	arg1	structures					663:672	three-dimensionally (3D)-print functional structures	621:672	three-dimensionally (3D)-print functional structures	621:672	These materials can be used to three-dimensionally (3D)-print functional structures, which are endowed with matrix-strengthening and crack healing when exposed to white light.
33431680	8	38	theme	lightweight	1203:1213	arg1	structures					1215:1224	lightweight structures	1203:1224	lightweight structures	1203:1224	This work opens the door for the design of hybrid synthetic-living materials, for applications such as smart composites, lightweight structures, and soft robotics.
33431680	3	39	theme	cell	373:376	arg1	structures					378:387	their cell structures	367:387	their cell structures	367:387	For example, plants strengthen their cell structures by transforming photosynthesis-produced glucose into stiff polysaccharides.
33431680	4	40	theme	hybrid	490:495	arg1	materials					497:505	hybrid materials	490:505	hybrid materials that use photosynthesis of embedded chloroplasts to remodel their microstructures	490:587	In this work, we realize hybrid materials that use photosynthesis of embedded chloroplasts to remodel their microstructures.
33431680	2	41	theme	living	225:230	arg1	organisms					232:240	living organisms	225:240	living organisms	225:240	By contrast, living organisms are able to strengthen their mechanical properties by regenerating parts of their structures.
33357898	8	0	theme	chemical	1143:1150	arg1	interaction					1162:1172	non-evident chemical interface interaction	1131:1172	non-evident chemical interface interaction in reactions	1131:1185	This study presents a way to unveil non-evident chemical interface interaction in reactions.
33357898	0	1	from	surface	23:29	arg1	reaction					57:64	enzymatic reaction	47:64	enzymatic reaction using data-mining	47:82	Lignocellulosic fibres surface interactions in enzymatic reaction using data-mining.
33357898	8	2	theme	non-evident	1131:1141	arg1	interaction					1162:1172	non-evident chemical interface interaction	1131:1172	non-evident chemical interface interaction in reactions	1131:1185	This study presents a way to unveil non-evident chemical interface interaction in reactions.
33357898	3	3	theme	lignocellulosic	509:523	arg1	hemp					539:542	hemp	539:542	hemp	539:542	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	3	theme	lignocellulosic	509:523	arg1	cellulose					548:556	cellulose	548:556	cellulose	548:556	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	3	theme	lignocellulosic	509:523	arg1	flax					533:536	flax	533:536	flax	533:536	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	3	theme	lignocellulosic	509:523	arg1	fibres					525:530	lignocellulosic fibres	509:530	lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition	509:603	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	4	theme	24	403:404	arg1	h					406:406	h	406:406	h	406:406	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	5	from	°C	439:440	arg1	reaction					408:415	A 24 h reaction	401:415	A 24 h reaction at either 25 °C or 60 °C, pH5	401:445	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	6	theme	h	406:406	arg1	reaction					408:415	A 24 h reaction	401:415	A 24 h reaction at either 25 °C or 60 °C, pH5	401:445	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	6	7	theme	extractive	964:973	arg1	profile					975:981	the extractive profile	960:981	the extractive profile	960:981	Fibres surface composition affected the extractive profile.
33357898	5	8	theme	reaction	823:830	arg1	products					832:839	specific reaction products	814:839	specific reaction products	814:839	At 25 °C, crystalline cellulose, amorphous cellulose, xylans, mannans, and lignins were well correlated to specific reaction products while at 60 °C, only lignins and xylan were found correlated to reaction products.
33357898	3	9	theme	trans-ferulic	476:488	arg1	acid					490:493	trans-ferulic acid	476:493	trans-ferulic acid	476:493	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	1	10	theme	Lignocellulosic	85:99	arg1	fibres					101:106	Lignocellulosic fibres	85:106	Lignocellulosic fibres modification	85:119	Lignocellulosic fibres modification focused so far essentially on the resulting material properties to create functional fibres instead of determining the reaction influencing parameters.
33357898	1	11	theme	functional	195:204	arg1	fibres					206:211	functional fibres	195:211	functional fibres instead of determining the reaction influencing parameters	195:270	Lignocellulosic fibres modification focused so far essentially on the resulting material properties to create functional fibres instead of determining the reaction influencing parameters.
33357898	5	12	theme	amorphous	740:748	arg1	°C					713:714	25 °C	710:714	25 °C	710:714	At 25 °C, crystalline cellulose, amorphous cellulose, xylans, mannans, and lignins were well correlated to specific reaction products while at 60 °C, only lignins and xylan were found correlated to reaction products.
33357898	5	12	theme	amorphous	740:748	arg1	cellulose					750:758	amorphous cellulose	740:758	amorphous cellulose	740:758	At 25 °C, crystalline cellulose, amorphous cellulose, xylans, mannans, and lignins were well correlated to specific reaction products while at 60 °C, only lignins and xylan were found correlated to reaction products.
33357898	5	13	dep	found	885:889	arg1	correlated					891:900	correlated	891:900	correlated to reaction products	891:921	At 25 °C, crystalline cellulose, amorphous cellulose, xylans, mannans, and lignins were well correlated to specific reaction products while at 60 °C, only lignins and xylan were found correlated to reaction products.
33357898	1	14	theme	fibres	101:106	arg1	modification					108:119	Lignocellulosic fibres modification	85:119	Lignocellulosic fibres modification	85:119	Lignocellulosic fibres modification focused so far essentially on the resulting material properties to create functional fibres instead of determining the reaction influencing parameters.
33357898	7	15	theme	mining	1078:1083	arg1	approach					1085:1092	a data mining approach	1071:1092	a data mining approach	1071:1092	Lignocellulosic surface composition influence on the product formed was unveiled using a data mining approach.
33357898	5	16	theme	reaction	905:912	arg1	products					914:921	reaction products	905:921	reaction products	905:921	At 25 °C, crystalline cellulose, amorphous cellulose, xylans, mannans, and lignins were well correlated to specific reaction products while at 60 °C, only lignins and xylan were found correlated to reaction products.
33357898	4	17	from	concentrations	651:664	arg1	extractive					695:704	extractive	695:704	extractive	695:704	Dimers and trimers were detected in variable concentrations in the reaction filtrate and extractive.
33357898	4	17	from	concentrations	651:664	arg1	filtrate					682:689	the reaction filtrate	669:689	the reaction filtrate	669:689	Dimers and trimers were detected in variable concentrations in the reaction filtrate and extractive.
33357898	4	18	theme	reaction	673:680	arg1	filtrate					682:689	the reaction filtrate	669:689	the reaction filtrate	669:689	Dimers and trimers were detected in variable concentrations in the reaction filtrate and extractive.
33357898	0	19	theme	Lignocellulosic	0:14	arg1	fibres					16:21	Lignocellulosic fibres	0:21	Lignocellulosic fibres	0:21	Lignocellulosic fibres surface interactions in enzymatic reaction using data-mining.
33357898	3	20	dep	fibres	525:530	arg1	hemp					539:542	hemp	539:542	hemp	539:542	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	20	dep	fibres	525:530	arg1	cellulose					548:556	cellulose	548:556	cellulose	548:556	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	20	dep	fibres	525:530	arg1	flax					533:536	flax	533:536	flax	533:536	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	20	dep	fibres	525:530	arg1	fibres					525:530	lignocellulosic fibres	509:530	lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition	509:603	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	5	21	theme	specific	814:821	arg1	products					832:839	specific reaction products	814:839	specific reaction products	814:839	At 25 °C, crystalline cellulose, amorphous cellulose, xylans, mannans, and lignins were well correlated to specific reaction products while at 60 °C, only lignins and xylan were found correlated to reaction products.
33357898	3	22	contain	having	559:564	arg1	hemp					539:542	hemp	539:542	hemp	539:542	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	22	contain	having	559:564	arg2	composition					593:603	different chemical surface composition	566:603	different chemical surface composition	566:603	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	22	contain	having	559:564	arg1	flax					533:536	flax	533:536	flax	533:536	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	22	contain	having	559:564	arg1	fibres					525:530	lignocellulosic fibres	509:530	lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition	509:603	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	22	contain	having	559:564	arg1	cellulose					548:556	cellulose	548:556	cellulose	548:556	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	7	23	theme	data	1073:1076	arg1	approach					1085:1092	a data mining approach	1071:1092	a data mining approach	1071:1092	Lignocellulosic surface composition influence on the product formed was unveiled using a data mining approach.
33357898	2	24	theme	fibres	340:345	arg1	composition					321:331	surface chemical composition	304:331	surface chemical composition of the fibres after modifications	304:365	Using a data-mining algorithm, surface chemical composition of the fibres after modifications was compared to multiple signals.
33357898	3	25	theme	fibres	525:530	arg1	presence					464:471	presence	464:471	presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition	464:603	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	0	26	theme	enzymatic	47:55	arg1	reaction					57:64	enzymatic reaction	47:64	enzymatic reaction using data-mining	47:82	Lignocellulosic fibres surface interactions in enzymatic reaction using data-mining.
33357898	6	27	theme	surface	931:937	arg1	composition					939:949	Fibres surface composition	924:949	Fibres surface composition	924:949	Fibres surface composition affected the extractive profile.
33357898	7	28	from	influence	1020:1028	arg1	product					1037:1043	the product	1033:1043	the product formed	1033:1050	Lignocellulosic surface composition influence on the product formed was unveiled using a data mining approach.
33357898	3	29	theme	surface	585:591	arg1	composition					593:603	different chemical surface composition	566:603	different chemical surface composition	566:603	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	4	30	theme	variable	642:649	arg1	concentrations					651:664	variable concentrations	642:664	variable concentrations in the reaction filtrate and extractive	642:704	Dimers and trimers were detected in variable concentrations in the reaction filtrate and extractive.
33357898	6	31	theme	Fibres	924:929	arg1	composition					939:949	Fibres surface composition	924:949	Fibres surface composition	924:949	Fibres surface composition affected the extractive profile.
33357898	5	32	theme	crystalline	717:727	arg1	°C					713:714	25 °C	710:714	25 °C	710:714	At 25 °C, crystalline cellulose, amorphous cellulose, xylans, mannans, and lignins were well correlated to specific reaction products while at 60 °C, only lignins and xylan were found correlated to reaction products.
33357898	5	32	theme	crystalline	717:727	arg1	cellulose					729:737	crystalline cellulose	717:737	crystalline cellulose	717:737	At 25 °C, crystalline cellulose, amorphous cellulose, xylans, mannans, and lignins were well correlated to specific reaction products while at 60 °C, only lignins and xylan were found correlated to reaction products.
33357898	3	33	theme	different	566:574	arg1	composition					593:603	different chemical surface composition	566:603	different chemical surface composition	566:603	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	3	34	theme	laccase	496:502	arg1	presence					464:471	presence	464:471	presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition	464:603	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	5	35	located	found	885:889	arg2	xylan					874:878	xylan	874:878	xylan	874:878	At 25 °C, crystalline cellulose, amorphous cellulose, xylans, mannans, and lignins were well correlated to specific reaction products while at 60 °C, only lignins and xylan were found correlated to reaction products.
33357898	5	35	located	found	885:889	arg1	°C					853:854	60 °C	850:854	60 °C	850:854	At 25 °C, crystalline cellulose, amorphous cellulose, xylans, mannans, and lignins were well correlated to specific reaction products while at 60 °C, only lignins and xylan were found correlated to reaction products.
33357898	5	35	located	found	885:889	arg2	lignins					862:868	lignins	862:868	lignins	862:868	At 25 °C, crystalline cellulose, amorphous cellulose, xylans, mannans, and lignins were well correlated to specific reaction products while at 60 °C, only lignins and xylan were found correlated to reaction products.
33357898	3	36	theme	chemical	576:583	arg1	composition					593:603	different chemical surface composition	566:603	different chemical surface composition	566:603	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	7	37	theme	surface	1000:1006	arg1	influence					1020:1028	Lignocellulosic surface composition influence	984:1028	Lignocellulosic surface composition influence on the product formed	984:1050	Lignocellulosic surface composition influence on the product formed was unveiled using a data mining approach.
33357898	2	38	theme	multiple	383:390	arg1	signals					392:398	multiple signals	383:398	multiple signals	383:398	Using a data-mining algorithm, surface chemical composition of the fibres after modifications was compared to multiple signals.
33357898	4	39	located	detected	630:637	arg2	trimers					617:623	trimers	617:623	trimers	617:623	Dimers and trimers were detected in variable concentrations in the reaction filtrate and extractive.
33357898	4	39	located	detected	630:637	arg2	Dimers					606:611	Dimers	606:611	Dimers	606:611	Dimers and trimers were detected in variable concentrations in the reaction filtrate and extractive.
33357898	4	39	located	detected	630:637	arg1	concentrations					651:664	variable concentrations	642:664	variable concentrations in the reaction filtrate and extractive	642:704	Dimers and trimers were detected in variable concentrations in the reaction filtrate and extractive.
33357898	2	40	theme	surface	304:310	arg1	composition					321:331	surface chemical composition	304:331	surface chemical composition of the fibres after modifications	304:365	Using a data-mining algorithm, surface chemical composition of the fibres after modifications was compared to multiple signals.
33357898	7	41	theme	composition	1008:1018	arg1	influence					1020:1028	Lignocellulosic surface composition influence	984:1028	Lignocellulosic surface composition influence on the product formed	984:1050	Lignocellulosic surface composition influence on the product formed was unveiled using a data mining approach.
33357898	3	42	theme	acid	490:493	arg1	presence					464:471	presence	464:471	presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition	464:603	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	2	43	theme	chemical	312:319	arg1	composition					321:331	surface chemical composition	304:331	surface chemical composition of the fibres after modifications	304:365	Using a data-mining algorithm, surface chemical composition of the fibres after modifications was compared to multiple signals.
33357898	8	44	from	interaction	1162:1172	arg1	reactions					1177:1185	reactions	1177:1185	reactions	1177:1185	This study presents a way to unveil non-evident chemical interface interaction in reactions.
33357898	1	45	theme	resulting	155:163	arg1	properties					174:183	the resulting material properties	151:183	the resulting material properties	151:183	Lignocellulosic fibres modification focused so far essentially on the resulting material properties to create functional fibres instead of determining the reaction influencing parameters.
33357898	7	46	theme	Lignocellulosic	984:998	arg1	influence					1020:1028	Lignocellulosic surface composition influence	984:1028	Lignocellulosic surface composition influence on the product formed	984:1050	Lignocellulosic surface composition influence on the product formed was unveiled using a data mining approach.
33357898	1	47	theme	material	165:172	arg1	properties					174:183	the resulting material properties	151:183	the resulting material properties	151:183	Lignocellulosic fibres modification focused so far essentially on the resulting material properties to create functional fibres instead of determining the reaction influencing parameters.
33357898	3	48	from	°C	430:431	arg1	reaction					408:415	A 24 h reaction	401:415	A 24 h reaction at either 25 °C or 60 °C, pH5	401:445	A 24 h reaction at either 25 °C or 60 °C, pH5 was conducted in presence of trans-ferulic acid, laccase, and lignocellulosic fibres (flax, hemp, or cellulose) having different chemical surface composition.
33357898	2	49	theme	data-mining	281:291	arg1	algorithm					293:301	a data-mining algorithm	279:301	a data-mining algorithm	279:301	Using a data-mining algorithm, surface chemical composition of the fibres after modifications was compared to multiple signals.
33357898	8	50	theme	interface	1152:1160	arg1	interaction					1162:1172	non-evident chemical interface interaction	1131:1172	non-evident chemical interface interaction in reactions	1131:1185	This study presents a way to unveil non-evident chemical interface interaction in reactions.
33385804	2	0	theme	sealing	485:491	arg1	washer					493:498	sealing washer	485:498	sealing washer	485:498	It was composed of cover plate, copper microelectrodes modified with poly-dopamine-co-chitosan (PDA-co-CS) composite gel, sealing washer and substrate containing copper sheet electrode.
33385804	1	1	theme	detection	325:333	arg1	functions					297:305	the functions	293:305	the functions of enrichment and detection	293:333	As the urgent need for rapid detection of airborne microbes in a specific environment, a biochip which was integrated with the functions of enrichment and detection was designed and developed.
33385804	5	2	theme	sheet	820:824	arg1	electrode					826:834	the copper sheet electrode	809:834	the copper sheet electrode	809:834	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	8	3	theme	Raman	1263:1267	arg1	SERS					1279:1282	SERS	1279:1282	SERS	1279:1282	Meanwhile, the Surface-enhanced Raman Spectrum (SERS) of different microbes were detected in-situ with the help of the silver sol.
33385804	8	3	theme	Raman	1263:1267	arg1	Spectrum					1269:1276	the Surface-enhanced Raman Spectrum	1242:1276	the Surface-enhanced Raman Spectrum (SERS) of different microbes	1242:1305	Meanwhile, the Surface-enhanced Raman Spectrum (SERS) of different microbes were detected in-situ with the help of the silver sol.
33385804	8	3	theme	Raman	1263:1267	arg1	Meanwhile					1231:1239	Meanwhile	1231:1239	Meanwhile	1231:1239	Meanwhile, the Surface-enhanced Raman Spectrum (SERS) of different microbes were detected in-situ with the help of the silver sol.
33385804	5	4	theme	Candida	1030:1036	arg1	albicans					1038:1045	Candida albicans	1030:1045	Candida albicans	1030:1045	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	9	5	theme	analysis	1495:1502	arg1	method					1510:1515	the principal component analysis (PCA) method	1471:1515	the principal component analysis (PCA) method	1471:1515	The SERS data of S. aureus, E. coli and Candida albicans had been analyzed to establish recognition model by the principal component analysis (PCA) method and the three microbes were successfully identified.
33385804	9	6	theme	SERS	1366:1369	arg1	data					1371:1374	The SERS data	1362:1374	The SERS data of S. aureus, E. coli and Candida albicans	1362:1417	The SERS data of S. aureus, E. coli and Candida albicans had been analyzed to establish recognition model by the principal component analysis (PCA) method and the three microbes were successfully identified.
33385804	7	7	theme	high	1173:1176	arg1	times					1164:1168	25 times	1161:1168	25 times as high as the detection limit of natural deposition method	1161:1228	aureus ATCC 6538, which was 25 times as high as the detection limit of natural deposition method.
33385804	8	8	theme	microbes	1298:1305	arg1	SERS					1279:1282	SERS	1279:1282	SERS	1279:1282	Meanwhile, the Surface-enhanced Raman Spectrum (SERS) of different microbes were detected in-situ with the help of the silver sol.
33385804	8	8	theme	microbes	1298:1305	arg1	Spectrum					1269:1276	the Surface-enhanced Raman Spectrum	1242:1276	the Surface-enhanced Raman Spectrum (SERS) of different microbes	1242:1305	Meanwhile, the Surface-enhanced Raman Spectrum (SERS) of different microbes were detected in-situ with the help of the silver sol.
33385804	8	8	theme	microbes	1298:1305	arg1	Meanwhile					1231:1239	Meanwhile	1231:1239	Meanwhile	1231:1239	Meanwhile, the Surface-enhanced Raman Spectrum (SERS) of different microbes were detected in-situ with the help of the silver sol.
33385804	2	9	theme	sheet	532:536	arg1	electrode					538:546	copper sheet electrode	525:546	copper sheet electrode	525:546	It was composed of cover plate, copper microelectrodes modified with poly-dopamine-co-chitosan (PDA-co-CS) composite gel, sealing washer and substrate containing copper sheet electrode.
33385804	5	10	theme	mixed	974:978	arg1	microbes					980:987	mixed microbes	974:987	mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans)	974:1046	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	10	theme	mixed	974:978	arg1	ATCC					1000:1003	S. aureus ATCC 6538	990:1008	S. aureus ATCC 6538	990:1008	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	10	theme	mixed	974:978	arg1	E.					1011:1012	E.	1011:1012	E.	1011:1012	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	11	used	used	841:844	arg2	system					754:759	The electrical impedance spectrum (EIS) test system	709:759	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode	709:834	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	12	theme	S.	949:950	arg1	6538					964:967	S. aureus ATCC 6538	949:967	S. aureus ATCC 6538	949:967	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	12	theme	S.	949:950	arg1	microbe					940:946	single microbe	933:946	single microbe (S. aureus ATCC 6538)	933:968	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	0	13	from	aerosol	161:167	arg1	detection					132:140	detection	132:140	detection	132:140	Study of biochip integrated with microelectrodes modified by poly-dopamine-co-chitosan composite gel for separation, enrichment and detection of microbes in the aerosol.
33385804	0	13	from	aerosol	161:167	arg1	enrichment					117:126	enrichment	117:126	enrichment	117:126	Study of biochip integrated with microelectrodes modified by poly-dopamine-co-chitosan composite gel for separation, enrichment and detection of microbes in the aerosol.
33385804	0	13	from	aerosol	161:167	arg1	separation					105:114	separation	105:114	separation	105:114	Study of biochip integrated with microelectrodes modified by poly-dopamine-co-chitosan composite gel for separation, enrichment and detection of microbes in the aerosol.
33385804	2	14	theme	copper	525:530	arg1	electrode					538:546	copper sheet electrode	525:546	copper sheet electrode	525:546	It was composed of cover plate, copper microelectrodes modified with poly-dopamine-co-chitosan (PDA-co-CS) composite gel, sealing washer and substrate containing copper sheet electrode.
33385804	9	15	theme	principal	1475:1483	arg1	PCA					1505:1507	PCA	1505:1507	PCA	1505:1507	The SERS data of S. aureus, E. coli and Candida albicans had been analyzed to establish recognition model by the principal component analysis (PCA) method and the three microbes were successfully identified.
33385804	9	15	theme	principal	1475:1483	arg1	analysis					1495:1502	principal component analysis	1475:1502	the principal component analysis (PCA) method	1471:1515	The SERS data of S. aureus, E. coli and Candida albicans had been analyzed to establish recognition model by the principal component analysis (PCA) method and the three microbes were successfully identified.
33385804	5	16	dep	E.	1011:1012	arg1	coli					1014:1017	E. coli JM109	1011:1023	E. coli JM109	1011:1023	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	16	dep	E.	1011:1012	arg1	JM109					1019:1023	JM109	1019:1023	JM109	1019:1023	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	17	theme	ATCC	959:962	arg1	6538					964:967	S. aureus ATCC 6538	949:967	S. aureus ATCC 6538	949:967	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	17	theme	ATCC	959:962	arg1	microbe					940:946	single microbe	933:946	single microbe (S. aureus ATCC 6538)	933:968	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	18	dep	microbes	980:987	arg1	microbes					980:987	mixed microbes	974:987	mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans)	974:1046	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	18	dep	microbes	980:987	arg1	ATCC					1000:1003	S. aureus ATCC 6538	990:1008	S. aureus ATCC 6538	990:1008	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	18	dep	microbes	980:987	arg1	E.					1011:1012	E.	1011:1012	E.	1011:1012	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	18	dep	microbes	980:987	arg1	albicans					1038:1045	Candida albicans	1030:1045	Candida albicans	1030:1045	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	19	theme	EIS	744:746	arg1	system					754:759	The electrical impedance spectrum (EIS) test system	709:759	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode	709:834	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	10	20	theme	designed	1599:1606	arg1	biochip					1608:1614	the designed biochip	1595:1614	the designed biochip	1595:1614	It was demonstrated that the designed biochip could be applied for separation, enrichment and detection of microbes in the aerosol.
33385804	10	21	theme	microbes	1677:1684	arg1	detection					1664:1672	detection	1664:1672	detection	1664:1672	It was demonstrated that the designed biochip could be applied for separation, enrichment and detection of microbes in the aerosol.
33385804	10	21	theme	microbes	1677:1684	arg1	enrichment					1649:1658	enrichment	1649:1658	enrichment	1649:1658	It was demonstrated that the designed biochip could be applied for separation, enrichment and detection of microbes in the aerosol.
33385804	10	21	theme	microbes	1677:1684	arg1	separation					1637:1646	separation	1637:1646	separation	1637:1646	It was demonstrated that the designed biochip could be applied for separation, enrichment and detection of microbes in the aerosol.
33385804	4	22	theme	enrichment	664:673	arg1	%					706:706	99.9%	702:706	99.9%	702:706	The enrichment efficiency of microbes was 99.9%.
33385804	4	22	theme	enrichment	664:673	arg1	efficiency					675:684	The enrichment efficiency	660:684	The enrichment efficiency of microbes	660:696	The enrichment efficiency of microbes was 99.9%.
33385804	5	23	theme	copper	787:792	arg1	electrodes					794:803	the copper electrodes	783:803	the copper electrodes	783:803	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	9	24	theme	Candida	1402:1408	arg1	albicans					1410:1417	Candida albicans	1402:1417	Candida albicans	1402:1417	The SERS data of S. aureus, E. coli and Candida albicans had been analyzed to establish recognition model by the principal component analysis (PCA) method and the three microbes were successfully identified.
33385804	9	25	theme	recognition	1450:1460	arg1	model					1462:1466	recognition model	1450:1466	recognition model	1450:1466	The SERS data of S. aureus, E. coli and Candida albicans had been analyzed to establish recognition model by the principal component analysis (PCA) method and the three microbes were successfully identified.
33385804	1	26	theme	urgent	177:182	arg1	need					184:187	the urgent need	173:187	the urgent need for rapid detection of airborne microbes in a specific environment	173:254	As the urgent need for rapid detection of airborne microbes in a specific environment, a biochip which was integrated with the functions of enrichment and detection was designed and developed.
33385804	1	26	theme	urgent	177:182	arg1	biochip					259:265	a biochip	257:265	a biochip which was integrated with the functions of enrichment and detection	257:333	As the urgent need for rapid detection of airborne microbes in a specific environment, a biochip which was integrated with the functions of enrichment and detection was designed and developed.
33385804	5	27	theme	aureus	993:998	arg1	microbes					980:987	mixed microbes	974:987	mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans)	974:1046	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	27	theme	aureus	993:998	arg1	ATCC					1000:1003	S. aureus ATCC 6538	990:1008	S. aureus ATCC 6538	990:1008	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	28	theme	test	749:752	arg1	system					754:759	The electrical impedance spectrum (EIS) test system	709:759	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode	709:834	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	29	theme	single	933:938	arg1	6538					964:967	S. aureus ATCC 6538	949:967	S. aureus ATCC 6538	949:967	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	29	theme	single	933:938	arg1	microbe					940:946	single microbe	933:946	single microbe (S. aureus ATCC 6538)	933:968	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	9	30	theme	component	1485:1493	arg1	PCA					1505:1507	PCA	1505:1507	PCA	1505:1507	The SERS data of S. aureus, E. coli and Candida albicans had been analyzed to establish recognition model by the principal component analysis (PCA) method and the three microbes were successfully identified.
33385804	9	30	theme	component	1485:1493	arg1	analysis					1495:1502	principal component analysis	1475:1502	the principal component analysis (PCA) method	1471:1515	The SERS data of S. aureus, E. coli and Candida albicans had been analyzed to establish recognition model by the principal component analysis (PCA) method and the three microbes were successfully identified.
33385804	2	31	theme	poly-dopamine-co-chitosan	432:456	arg1	gel					480:482	poly-dopamine-co-chitosan (PDA-co-CS) composite gel	432:482	poly-dopamine-co-chitosan (PDA-co-CS) composite gel	432:482	It was composed of cover plate, copper microelectrodes modified with poly-dopamine-co-chitosan (PDA-co-CS) composite gel, sealing washer and substrate containing copper sheet electrode.
33385804	5	32	theme	microbe	940:946	arg1	method					923:928	the quantitative detection method	896:928	the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans)	896:1046	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	3	33	dep	efficiency	604:613	arg1	the					583:585	the	583:585	the	583:585	The microbes were enriched due to the good ventilation efficiency and adhesion of the PDA-co-CS composite gel.
33385804	8	34	theme	silver	1350:1355	arg1	sol					1357:1359	the silver sol	1346:1359	the silver sol	1346:1359	Meanwhile, the Surface-enhanced Raman Spectrum (SERS) of different microbes were detected in-situ with the help of the silver sol.
33385804	8	35	theme	Surface-enhanced	1246:1261	arg1	SERS					1279:1282	SERS	1279:1282	SERS	1279:1282	Meanwhile, the Surface-enhanced Raman Spectrum (SERS) of different microbes were detected in-situ with the help of the silver sol.
33385804	8	35	theme	Surface-enhanced	1246:1261	arg1	Spectrum					1269:1276	the Surface-enhanced Raman Spectrum	1242:1276	the Surface-enhanced Raman Spectrum (SERS) of different microbes	1242:1305	Meanwhile, the Surface-enhanced Raman Spectrum (SERS) of different microbes were detected in-situ with the help of the silver sol.
33385804	8	35	theme	Surface-enhanced	1246:1261	arg1	Meanwhile					1231:1239	Meanwhile	1231:1239	Meanwhile	1231:1239	Meanwhile, the Surface-enhanced Raman Spectrum (SERS) of different microbes were detected in-situ with the help of the silver sol.
33385804	5	36	theme	S.	990:991	arg1	microbes					980:987	mixed microbes	974:987	mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans)	974:1046	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	36	theme	S.	990:991	arg1	ATCC					1000:1003	S. aureus ATCC 6538	990:1008	S. aureus ATCC 6538	990:1008	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	1	37	theme	rapid	193:197	arg1	detection					199:207	rapid detection	193:207	rapid detection of airborne microbes in a specific environment	193:254	As the urgent need for rapid detection of airborne microbes in a specific environment, a biochip which was integrated with the functions of enrichment and detection was designed and developed.
33385804	0	38	theme	biochip	9:15	arg1	Study					0:4	Study	0:4	Study of biochip	0:15	Study of biochip integrated with microelectrodes modified by poly-dopamine-co-chitosan composite gel for separation, enrichment and detection of microbes in the aerosol.
33385804	9	39	theme	coli	1393:1396	arg1	data					1371:1374	The SERS data	1362:1374	The SERS data of S. aureus, E. coli and Candida albicans	1362:1417	The SERS data of S. aureus, E. coli and Candida albicans had been analyzed to establish recognition model by the principal component analysis (PCA) method and the three microbes were successfully identified.
33385804	3	40	theme	gel	655:657	arg1	adhesion					619:626	adhesion	619:626	adhesion	619:626	The microbes were enriched due to the good ventilation efficiency and adhesion of the PDA-co-CS composite gel.
33385804	3	40	theme	gel	655:657	arg1	efficiency					604:613	good ventilation efficiency	587:613	good ventilation efficiency	587:613	The microbes were enriched due to the good ventilation efficiency and adhesion of the PDA-co-CS composite gel.
33385804	5	41	theme	impedance	724:732	arg1	system					754:759	The electrical impedance spectrum (EIS) test system	709:759	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode	709:834	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	2	42	theme	copper	395:400	arg1	microelectrodes					402:416	copper microelectrodes	395:416	copper microelectrodes modified with poly-dopamine-co-chitosan (PDA-co-CS) composite gel	395:482	It was composed of cover plate, copper microelectrodes modified with poly-dopamine-co-chitosan (PDA-co-CS) composite gel, sealing washer and substrate containing copper sheet electrode.
33385804	7	43	theme	method	1223:1228	arg1	limit					1195:1199	the detection limit	1181:1199	the detection limit of natural deposition method	1181:1228	aureus ATCC 6538, which was 25 times as high as the detection limit of natural deposition method.
33385804	5	44	theme	aureus	952:957	arg1	6538					964:967	S. aureus ATCC 6538	949:967	S. aureus ATCC 6538	949:967	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	44	theme	aureus	952:957	arg1	microbe					940:946	single microbe	933:946	single microbe (S. aureus ATCC 6538)	933:968	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	5	45	theme	electrical	713:722	arg1	system					754:759	The electrical impedance spectrum (EIS) test system	709:759	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode	709:834	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	3	46	theme	ventilation	592:602	arg1	efficiency					604:613	good ventilation efficiency	587:613	good ventilation efficiency	587:613	The microbes were enriched due to the good ventilation efficiency and adhesion of the PDA-co-CS composite gel.
33385804	5	47	theme	concentrated	860:871	arg1	microbes					873:880	the concentrated microbes	856:880	the concentrated microbes	856:880	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	7	48	theme	deposition	1212:1221	arg1	method					1223:1228	natural deposition method	1204:1228	natural deposition method	1204:1228	aureus ATCC 6538, which was 25 times as high as the detection limit of natural deposition method.
33385804	2	49	theme	composite	470:478	arg1	gel					480:482	poly-dopamine-co-chitosan (PDA-co-CS) composite gel	432:482	poly-dopamine-co-chitosan (PDA-co-CS) composite gel	432:482	It was composed of cover plate, copper microelectrodes modified with poly-dopamine-co-chitosan (PDA-co-CS) composite gel, sealing washer and substrate containing copper sheet electrode.
33385804	0	50	theme	microbes	145:152	arg1	detection					132:140	detection	132:140	detection	132:140	Study of biochip integrated with microelectrodes modified by poly-dopamine-co-chitosan composite gel for separation, enrichment and detection of microbes in the aerosol.
33385804	0	50	theme	microbes	145:152	arg1	enrichment					117:126	enrichment	117:126	enrichment	117:126	Study of biochip integrated with microelectrodes modified by poly-dopamine-co-chitosan composite gel for separation, enrichment and detection of microbes in the aerosol.
33385804	0	50	theme	microbes	145:152	arg1	separation					105:114	separation	105:114	separation	105:114	Study of biochip integrated with microelectrodes modified by poly-dopamine-co-chitosan composite gel for separation, enrichment and detection of microbes in the aerosol.
33385804	3	51	theme	PDA-co-CS	635:643	arg1	gel					655:657	the PDA-co-CS composite gel	631:657	the PDA-co-CS composite gel	631:657	The microbes were enriched due to the good ventilation efficiency and adhesion of the PDA-co-CS composite gel.
33385804	2	52	dep	plate	388:392	arg1	cover					382:386	cover	382:386	cover	382:386	It was composed of cover plate, copper microelectrodes modified with poly-dopamine-co-chitosan (PDA-co-CS) composite gel, sealing washer and substrate containing copper sheet electrode.
33385804	1	53	theme	airborne	212:219	arg1	microbes					221:228	airborne microbes	212:228	airborne microbes	212:228	As the urgent need for rapid detection of airborne microbes in a specific environment, a biochip which was integrated with the functions of enrichment and detection was designed and developed.
33385804	5	54	theme	spectrum	734:741	arg1	system					754:759	The electrical impedance spectrum (EIS) test system	709:759	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode	709:834	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	8	55	theme	different	1288:1296	arg1	microbes					1298:1305	different microbes	1288:1305	different microbes	1288:1305	Meanwhile, the Surface-enhanced Raman Spectrum (SERS) of different microbes were detected in-situ with the help of the silver sol.
33385804	3	56	theme	composite	645:653	arg1	gel					655:657	the PDA-co-CS composite gel	631:657	the PDA-co-CS composite gel	631:657	The microbes were enriched due to the good ventilation efficiency and adhesion of the PDA-co-CS composite gel.
33385804	5	57	theme	quantitative	900:911	arg1	method					923:928	the quantitative detection method	896:928	the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans)	896:1046	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	2	58	theme	PDA-co-CS	459:467	arg1	gel					480:482	poly-dopamine-co-chitosan (PDA-co-CS) composite gel	432:482	poly-dopamine-co-chitosan (PDA-co-CS) composite gel	432:482	It was composed of cover plate, copper microelectrodes modified with poly-dopamine-co-chitosan (PDA-co-CS) composite gel, sealing washer and substrate containing copper sheet electrode.
33385804	7	59	theme	ATCC	1140:1143	arg1	6538					1145:1148	aureus ATCC 6538	1133:1148	aureus ATCC 6538	1133:1148	aureus ATCC 6538, which was 25 times as high as the detection limit of natural deposition method.
33385804	3	60	theme	good	587:590	arg1	efficiency					604:613	good ventilation efficiency	587:613	good ventilation efficiency	587:613	The microbes were enriched due to the good ventilation efficiency and adhesion of the PDA-co-CS composite gel.
33385804	5	61	theme	detection	913:921	arg1	method					923:928	the quantitative detection method	896:928	the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans)	896:1046	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	10	62	from	separation	1637:1646	arg1	aerosol					1693:1699	the aerosol	1689:1699	the aerosol	1689:1699	It was demonstrated that the designed biochip could be applied for separation, enrichment and detection of microbes in the aerosol.
33385804	1	63	theme	enrichment	310:319	arg1	functions					297:305	the functions	293:305	the functions of enrichment and detection	293:333	As the urgent need for rapid detection of airborne microbes in a specific environment, a biochip which was integrated with the functions of enrichment and detection was designed and developed.
33385804	0	64	from	enrichment	117:126	arg1	aerosol					161:167	the aerosol	157:167	the aerosol	157:167	Study of biochip integrated with microelectrodes modified by poly-dopamine-co-chitosan composite gel for separation, enrichment and detection of microbes in the aerosol.
33385804	1	65	from	detection	199:207	arg1	environment					244:254	a specific environment	233:254	a specific environment	233:254	As the urgent need for rapid detection of airborne microbes in a specific environment, a biochip which was integrated with the functions of enrichment and detection was designed and developed.
33385804	7	66	theme	detection	1185:1193	arg1	limit					1195:1199	the detection limit	1181:1199	the detection limit of natural deposition method	1181:1228	aureus ATCC 6538, which was 25 times as high as the detection limit of natural deposition method.
33385804	1	67	theme	microbes	221:228	arg1	detection					199:207	rapid detection	193:207	rapid detection of airborne microbes in a specific environment	193:254	As the urgent need for rapid detection of airborne microbes in a specific environment, a biochip which was integrated with the functions of enrichment and detection was designed and developed.
33385804	7	68	theme	natural	1204:1210	arg1	method					1223:1228	natural deposition method	1204:1228	natural deposition method	1204:1228	aureus ATCC 6538, which was 25 times as high as the detection limit of natural deposition method.
33385804	5	69	theme	copper	813:818	arg1	electrode					826:834	the copper sheet electrode	809:834	the copper sheet electrode	809:834	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	9	70	theme	albicans	1410:1417	arg1	data					1371:1374	The SERS data	1362:1374	The SERS data of S. aureus, E. coli and Candida albicans	1362:1417	The SERS data of S. aureus, E. coli and Candida albicans had been analyzed to establish recognition model by the principal component analysis (PCA) method and the three microbes were successfully identified.
33385804	10	71	from	enrichment	1649:1658	arg1	aerosol					1693:1699	the aerosol	1689:1699	the aerosol	1689:1699	It was demonstrated that the designed biochip could be applied for separation, enrichment and detection of microbes in the aerosol.
33385804	0	72	from	microbes	145:152	arg1	aerosol					161:167	the aerosol	157:167	the aerosol	157:167	Study of biochip integrated with microelectrodes modified by poly-dopamine-co-chitosan composite gel for separation, enrichment and detection of microbes in the aerosol.
33385804	0	73	theme	composite	87:95	arg1	gel					97:99	poly-dopamine-co-chitosan composite gel	61:99	poly-dopamine-co-chitosan composite gel	61:99	Study of biochip integrated with microelectrodes modified by poly-dopamine-co-chitosan composite gel for separation, enrichment and detection of microbes in the aerosol.
33385804	0	74	from	separation	105:114	arg1	aerosol					161:167	the aerosol	157:167	the aerosol	157:167	Study of biochip integrated with microelectrodes modified by poly-dopamine-co-chitosan composite gel for separation, enrichment and detection of microbes in the aerosol.
33385804	5	75	theme	microbes	980:987	arg1	method					923:928	the quantitative detection method	896:928	the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans)	896:1046	The electrical impedance spectrum (EIS) test system which was composed of the copper electrodes and the copper sheet electrode were used to detect the concentrated microbes and establish the quantitative detection method of single microbe (S. aureus ATCC 6538) and mixed microbes (S. aureus ATCC 6538, E. coli JM109, and Candida albicans).
33385804	2	76	contain	containing	514:523	arg2	electrode					538:546	copper sheet electrode	525:546	copper sheet electrode	525:546	It was composed of cover plate, copper microelectrodes modified with poly-dopamine-co-chitosan (PDA-co-CS) composite gel, sealing washer and substrate containing copper sheet electrode.
33385804	2	76	contain	containing	514:523	arg1	substrate					504:512	substrate	504:512	substrate containing copper sheet electrode	504:546	It was composed of cover plate, copper microelectrodes modified with poly-dopamine-co-chitosan (PDA-co-CS) composite gel, sealing washer and substrate containing copper sheet electrode.
33385804	8	77	dep	the	1334:1336	arg1	help					1338:1341	help	1338:1341	help	1338:1341	Meanwhile, the Surface-enhanced Raman Spectrum (SERS) of different microbes were detected in-situ with the help of the silver sol.
33385804	9	78	theme	aureus	1382:1387	arg1	data					1371:1374	The SERS data	1362:1374	The SERS data of S. aureus, E. coli and Candida albicans	1362:1417	The SERS data of S. aureus, E. coli and Candida albicans had been analyzed to establish recognition model by the principal component analysis (PCA) method and the three microbes were successfully identified.
33385804	0	79	theme	poly-dopamine-co-chitosan	61:85	arg1	gel					97:99	poly-dopamine-co-chitosan composite gel	61:99	poly-dopamine-co-chitosan composite gel	61:99	Study of biochip integrated with microelectrodes modified by poly-dopamine-co-chitosan composite gel for separation, enrichment and detection of microbes in the aerosol.
33385804	7	80	theme	aureus	1133:1138	arg1	6538					1145:1148	aureus ATCC 6538	1133:1148	aureus ATCC 6538	1133:1148	aureus ATCC 6538, which was 25 times as high as the detection limit of natural deposition method.
33385804	0	81	from	detection	132:140	arg1	aerosol					161:167	the aerosol	157:167	the aerosol	157:167	Study of biochip integrated with microelectrodes modified by poly-dopamine-co-chitosan composite gel for separation, enrichment and detection of microbes in the aerosol.
33385804	4	82	theme	microbes	689:696	arg1	%					706:706	99.9%	702:706	99.9%	702:706	The enrichment efficiency of microbes was 99.9%.
33385804	4	82	theme	microbes	689:696	arg1	efficiency					675:684	The enrichment efficiency	660:684	The enrichment efficiency of microbes	660:696	The enrichment efficiency of microbes was 99.9%.
33385804	10	83	from	detection	1664:1672	arg1	aerosol					1693:1699	the aerosol	1689:1699	the aerosol	1689:1699	It was demonstrated that the designed biochip could be applied for separation, enrichment and detection of microbes in the aerosol.
33385804	1	84	theme	specific	235:242	arg1	environment					244:254	a specific environment	233:254	a specific environment	233:254	As the urgent need for rapid detection of airborne microbes in a specific environment, a biochip which was integrated with the functions of enrichment and detection was designed and developed.
31978715	2	0	theme	SDF	456:458	arg1	complex					460:466	the SDF complex	452:466	the SDF complex	452:466	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	0	1	from	fiber	16:20	arg1	root					54:57	lotus root	48:57	lotus root	48:57	Soluble dietary fiber and polyphenol complex in lotus root: Preparation, interaction and identification.
31978715	7	2	theme	higher	1098:1103	arg1	stability					1113:1121	higher thermal stability	1098:1121	higher thermal stability	1098:1121	Both SDF-CC and SDF-GA complex indicated higher thermal stability than the mixtures by TGA analysis.
31978715	2	3	from	catechin	424:431	arg1	complex					460:466	the SDF complex	452:466	the SDF complex	452:466	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	7	4	theme	thermal	1105:1111	arg1	stability					1113:1121	higher thermal stability	1098:1121	higher thermal stability	1098:1121	Both SDF-CC and SDF-GA complex indicated higher thermal stability than the mixtures by TGA analysis.
31978715	2	5	theme	pH = 4	313:318	arg1	conditions					299:308	the conditions	295:308	the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1	295:395	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	1	6	theme	phenols	243:249	arg1	complex					196:202	the complex	192:202	the complex of soluble dietary fiber (SDF) and two phenols	192:249	In order to further determine the interaction between polysaccharides and polyphenols, the complex of soluble dietary fiber (SDF) and two phenols were prepared.
31978715	2	7	from	conditions	299:308	arg1	134.05 mg/g					483:493	134.05 mg/g	483:493	134.05 mg/g	483:493	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	2	7	from	conditions	299:308	arg1	adsorption					410:419	the maximum adsorption	398:419	the maximum adsorption of catechin and gallic acid in the SDF complex	398:466	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	2	7	from	conditions	299:308	arg1	155.74					472:477	155.74	472:477	155.74	472:477	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	6	8	with	porous	1017:1022	arg1	cracks					1049:1054	cracks	1049:1054	cracks	1049:1054	The surface of SDF-phenol complex was loose with uniform arrangement, while the physical mixture surface was porous with irregular holes and cracks.
31978715	6	8	with	porous	1017:1022	arg1	holes					1039:1043	irregular holes	1029:1043	irregular holes	1029:1043	The surface of SDF-phenol complex was loose with uniform arrangement, while the physical mixture surface was porous with irregular holes and cracks.
31978715	5	9	theme	SDF-phenol	856:865	arg1	complexes					867:875	two different SDF-phenol complexes	842:875	two different SDF-phenol complexes	842:875	However, it showed no significant difference between two different SDF-phenol complexes, referring to GC and GPC data.
31978715	2	10	theme	polysaccharide	365:378	arg1	phenol = 4:1					384:395	phenol = 4:1	384:395	phenol = 4:1	384:395	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	2	10	theme	polysaccharide	365:378	arg1	temperature = 60 °C					321:339	temperature = 60 °C	321:339	temperature = 60 °C	321:339	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	2	10	theme	polysaccharide	365:378	arg1	ratio					356:360	concentration ratio	342:360	concentration ratio of polysaccharide	342:378	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	2	10	theme	polysaccharide	365:378	arg1	pH = 4					313:318	pH = 4	313:318	pH = 4	313:318	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	6	11	theme	uniform	957:963	arg1	arrangement					965:975	uniform arrangement	957:975	uniform arrangement	957:975	The surface of SDF-phenol complex was loose with uniform arrangement, while the physical mixture surface was porous with irregular holes and cracks.
31978715	0	12	from	complex	37:43	arg1	root					54:57	lotus root	48:57	lotus root	48:57	Soluble dietary fiber and polyphenol complex in lotus root: Preparation, interaction and identification.
31978715	7	13	theme	SDF-GA	1073:1078	arg1	complex					1080:1086	SDF-GA complex	1073:1086	SDF-GA complex	1073:1086	Both SDF-CC and SDF-GA complex indicated higher thermal stability than the mixtures by TGA analysis.
31978715	2	14	theme	catechin	424:431	arg1	adsorption					410:419	the maximum adsorption	398:419	the maximum adsorption of catechin and gallic acid in the SDF complex	398:466	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	2	14	theme	catechin	424:431	arg1	155.74					472:477	155.74	472:477	155.74	472:477	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	5	15	theme	different	846:854	arg1	complexes					867:875	two different SDF-phenol complexes	842:875	two different SDF-phenol complexes	842:875	However, it showed no significant difference between two different SDF-phenol complexes, referring to GC and GPC data.
31978715	0	16	theme	dietary	8:14	arg1	fiber					16:20	Soluble dietary fiber	0:20	Soluble dietary fiber	0:20	Soluble dietary fiber and polyphenol complex in lotus root: Preparation, interaction and identification.
31978715	2	17	from	acid	444:447	arg1	complex					460:466	the SDF complex	452:466	the SDF complex	452:466	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	3	18	theme	FT-IR	528:532	arg1	analysis					534:541	FT-IR analysis	528:541	FT-IR analysis	528:541	Due to UV-Vis and FT-IR analysis, it could be speculated that the interaction between SDF and phenols resulted in chemical combination.
31978715	2	19	theme	ratio	356:360	arg1	conditions					299:308	the conditions	295:308	the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1	295:395	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	0	20	theme	Soluble	0:6	arg1	fiber					16:20	Soluble dietary fiber	0:20	Soluble dietary fiber	0:20	Soluble dietary fiber and polyphenol complex in lotus root: Preparation, interaction and identification.
31978715	4	21	theme	weight	704:709	arg1	distribution					711:722	molecular weight distribution	694:722	molecular weight distribution	694:722	Furthermore, the monosaccharide composition and molecular weight distribution of SDF were significantly altered after conjugated with phenols.
31978715	2	22	theme	concentration	342:354	arg1	ratio					356:360	concentration ratio	342:360	concentration ratio of polysaccharide	342:378	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	4	23	theme	SDF	727:729	arg1	composition					678:688	monosaccharide composition	663:688	monosaccharide composition	663:688	Furthermore, the monosaccharide composition and molecular weight distribution of SDF were significantly altered after conjugated with phenols.
31978715	4	23	theme	SDF	727:729	arg1	distribution					711:722	molecular weight distribution	694:722	molecular weight distribution	694:722	Furthermore, the monosaccharide composition and molecular weight distribution of SDF were significantly altered after conjugated with phenols.
31978715	6	24	theme	irregular	1029:1037	arg1	holes					1039:1043	irregular holes	1029:1043	irregular holes	1029:1043	The surface of SDF-phenol complex was loose with uniform arrangement, while the physical mixture surface was porous with irregular holes and cracks.
31978715	2	25	theme	maximum	402:408	arg1	adsorption					410:419	the maximum adsorption	398:419	the maximum adsorption of catechin and gallic acid in the SDF complex	398:466	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	2	25	theme	maximum	402:408	arg1	155.74					472:477	155.74	472:477	155.74	472:477	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	5	26	theme	significant	811:821	arg1	difference					823:832	no significant difference	808:832	no significant difference between two different SDF-phenol complexes, referring to GC and GPC data	808:905	However, it showed no significant difference between two different SDF-phenol complexes, referring to GC and GPC data.
31978715	5	27	theme	GPC	898:900	arg1	data					902:905	GPC data	898:905	GPC data	898:905	However, it showed no significant difference between two different SDF-phenol complexes, referring to GC and GPC data.
31978715	6	28	theme	complex	934:940	arg1	loose					946:950	loose	946:950	loose	946:950	The surface of SDF-phenol complex was loose with uniform arrangement, while the physical mixture surface was porous with irregular holes and cracks.
31978715	6	28	theme	complex	934:940	arg1	surface					912:918	The surface	908:918	The surface of SDF-phenol complex	908:940	The surface of SDF-phenol complex was loose with uniform arrangement, while the physical mixture surface was porous with irregular holes and cracks.
31978715	2	29	theme	phenol = 4:1	384:395	arg1	conditions					299:308	the conditions	295:308	the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1	295:395	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	2	30	theme	acid	444:447	arg1	adsorption					410:419	the maximum adsorption	398:419	the maximum adsorption of catechin and gallic acid in the SDF complex	398:466	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	2	30	theme	acid	444:447	arg1	155.74					472:477	155.74	472:477	155.74	472:477	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	6	31	theme	SDF-phenol	923:932	arg1	complex					934:940	SDF-phenol complex	923:940	SDF-phenol complex	923:940	The surface of SDF-phenol complex was loose with uniform arrangement, while the physical mixture surface was porous with irregular holes and cracks.
31978715	0	32	theme	polyphenol	26:35	arg1	complex					37:43	polyphenol complex	26:43	polyphenol complex	26:43	Soluble dietary fiber and polyphenol complex in lotus root: Preparation, interaction and identification.
31978715	1	33	theme	soluble	207:213	arg1	SDF					230:232	SDF	230:232	SDF	230:232	In order to further determine the interaction between polysaccharides and polyphenols, the complex of soluble dietary fiber (SDF) and two phenols were prepared.
31978715	1	33	theme	soluble	207:213	arg1	fiber					223:227	soluble dietary fiber	207:227	soluble dietary fiber (SDF)	207:233	In order to further determine the interaction between polysaccharides and polyphenols, the complex of soluble dietary fiber (SDF) and two phenols were prepared.
31978715	0	34	theme	lotus	48:52	arg1	root					54:57	lotus root	48:57	lotus root	48:57	Soluble dietary fiber and polyphenol complex in lotus root: Preparation, interaction and identification.
31978715	2	35	from	complex	460:466	arg1	adsorption					410:419	the maximum adsorption	398:419	the maximum adsorption of catechin and gallic acid in the SDF complex	398:466	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	2	35	from	complex	460:466	arg1	155.74					472:477	155.74	472:477	155.74	472:477	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	3	36	theme	chemical	624:631	arg1	combination					633:643	chemical combination	624:643	chemical combination	624:643	Due to UV-Vis and FT-IR analysis, it could be speculated that the interaction between SDF and phenols resulted in chemical combination.
31978715	4	37	theme	monosaccharide	663:676	arg1	composition					678:688	monosaccharide composition	663:688	monosaccharide composition	663:688	Furthermore, the monosaccharide composition and molecular weight distribution of SDF were significantly altered after conjugated with phenols.
31978715	6	38	theme	mixture	997:1003	arg1	porous					1017:1022	porous	1017:1022	porous	1017:1022	The surface of SDF-phenol complex was loose with uniform arrangement, while the physical mixture surface was porous with irregular holes and cracks.
31978715	6	38	theme	mixture	997:1003	arg1	surface					1005:1011	the physical mixture surface	984:1011	the physical mixture surface	984:1011	The surface of SDF-phenol complex was loose with uniform arrangement, while the physical mixture surface was porous with irregular holes and cracks.
31978715	4	39	theme	molecular	694:702	arg1	distribution					711:722	molecular weight distribution	694:722	molecular weight distribution	694:722	Furthermore, the monosaccharide composition and molecular weight distribution of SDF were significantly altered after conjugated with phenols.
31978715	4	40	dep	composition	678:688	arg1	the					659:661	the	659:661	the	659:661	Furthermore, the monosaccharide composition and molecular weight distribution of SDF were significantly altered after conjugated with phenols.
31978715	1	41	theme	dietary	215:221	arg1	SDF					230:232	SDF	230:232	SDF	230:232	In order to further determine the interaction between polysaccharides and polyphenols, the complex of soluble dietary fiber (SDF) and two phenols were prepared.
31978715	1	41	theme	dietary	215:221	arg1	fiber					223:227	soluble dietary fiber	207:227	soluble dietary fiber (SDF)	207:233	In order to further determine the interaction between polysaccharides and polyphenols, the complex of soluble dietary fiber (SDF) and two phenols were prepared.
31978715	6	42	with	loose	946:950	arg1	arrangement					965:975	uniform arrangement	957:975	uniform arrangement	957:975	The surface of SDF-phenol complex was loose with uniform arrangement, while the physical mixture surface was porous with irregular holes and cracks.
31978715	0	43	dep	fiber	16:20	arg1	Preparation					60:70	Preparation	60:70	Preparation	60:70	Soluble dietary fiber and polyphenol complex in lotus root: Preparation, interaction and identification.
31978715	0	43	dep	fiber	16:20	arg1	identification					89:102	identification	89:102	identification	89:102	Soluble dietary fiber and polyphenol complex in lotus root: Preparation, interaction and identification.
31978715	0	43	dep	fiber	16:20	arg1	interaction					73:83	interaction	73:83	interaction	73:83	Soluble dietary fiber and polyphenol complex in lotus root: Preparation, interaction and identification.
31978715	1	44	theme	fiber	223:227	arg1	complex					196:202	the complex	192:202	the complex of soluble dietary fiber (SDF) and two phenols	192:249	In order to further determine the interaction between polysaccharides and polyphenols, the complex of soluble dietary fiber (SDF) and two phenols were prepared.
31978715	6	45	theme	physical	988:995	arg1	porous					1017:1022	porous	1017:1022	porous	1017:1022	The surface of SDF-phenol complex was loose with uniform arrangement, while the physical mixture surface was porous with irregular holes and cracks.
31978715	6	45	theme	physical	988:995	arg1	surface					1005:1011	the physical mixture surface	984:1011	the physical mixture surface	984:1011	The surface of SDF-phenol complex was loose with uniform arrangement, while the physical mixture surface was porous with irregular holes and cracks.
31978715	2	46	theme	gallic	437:442	arg1	acid					444:447	gallic acid	437:447	gallic acid	437:447	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	2	47	from	adsorption	410:419	arg1	complex					460:466	the SDF complex	452:466	the SDF complex	452:466	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
31978715	7	48	theme	TGA	1144:1146	arg1	analysis					1148:1155	TGA analysis	1144:1155	TGA analysis	1144:1155	Both SDF-CC and SDF-GA complex indicated higher thermal stability than the mixtures by TGA analysis.
31978715	2	49	theme	temperature = 60 °C	321:339	arg1	conditions					299:308	the conditions	295:308	the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1	295:395	According to the results, at the conditions of pH = 4, temperature = 60 °C, concentration ratio of polysaccharide and phenol = 4:1, the maximum adsorption of catechin and gallic acid in the SDF complex was 155.74 and 134.05 mg/g, respectively.
32409070	11	0	from	activation	1507:1516	arg1	surfaces					1533:1540	biomaterial surfaces	1521:1540	biomaterial surfaces	1521:1540	This study provides a new perspective for understanding platelet adhesion and activation on biomaterial surfaces, toward the development of new blood-compatible surfaces using a tannin derivative-based polymer.
32409070	10	1	theme	strong	1347:1352	arg1	association					1354:1364	strong association	1347:1364	strong association	1347:1364	These chemical features enable strong association with fibrinogen, which promotes the platelet-repelling effect.
32409070	4	2	theme	platelets	679:687	arg1	proteins					642:649	key blood serum proteins	626:649	key blood serum proteins	626:649	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	4	2	theme	platelets	679:687	arg1	activation					665:674	activation	665:674	activation of platelets	665:687	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	4	2	theme	platelets	679:687	arg1	adhesion					652:659	adhesion	652:659	adhesion	652:659	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	5	3	theme	similar	749:755	arg1	albumin					768:774	albumin	768:774	albumin	768:774	TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups.
32409070	5	3	theme	similar	749:755	arg1	amounts					757:763	similar amounts	749:763	similar amounts of albumin	749:774	TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups.
32409070	7	4	theme	TN-based	1126:1133	arg1	PEMs					1135:1138	TN-based PEMs	1126:1138	TN-based PEMs	1126:1138	The whole-blood clotting kinetics assay also shows lower blood coagulation on TN-based PEMs.
32409070	0	5	with	interactions	106:117	arg1	platelets					124:132	platelets	124:132	platelets	124:132	Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins.
32409070	0	5	with	interactions	106:117	arg1	proteins					144:151	serum proteins	138:151	serum proteins	138:151	Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins.
32409070	5	6	theme	catechol	876:883	arg1	groups					885:890	catechol groups	876:890	catechol groups	876:890	TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups.
32409070	11	7	theme	biomaterial	1521:1531	arg1	surfaces					1533:1540	biomaterial surfaces	1521:1540	biomaterial surfaces	1521:1540	This study provides a new perspective for understanding platelet adhesion and activation on biomaterial surfaces, toward the development of new blood-compatible surfaces using a tannin derivative-based polymer.
32409070	8	8	theme	amphoteric	1150:1159	arg1	TN					1141:1142	TN	1141:1142	TN	1141:1142	TN is an amphoteric, cationic, condensed tannin derivative with resonance structures.
32409070	8	8	theme	amphoteric	1150:1159	arg1	derivative					1189:1198	an amphoteric, cationic, condensed tannin derivative	1147:1198	an amphoteric, cationic, condensed tannin derivative with resonance structures	1147:1224	TN is an amphoteric, cationic, condensed tannin derivative with resonance structures.
32409070	1	9	dep	glycosaminoglycans	286:303	arg1	heparin					305:311	heparin	305:311	heparin (HEP)	305:317	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	1	9	dep	glycosaminoglycans	286:303	arg1	CS					344:345	CS	344:345	CS	344:345	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	1	9	dep	glycosaminoglycans	286:303	arg1	sulfate					335:341	chondroitin sulfate	323:341	chondroitin sulfate (CS)	323:346	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	1	9	dep	glycosaminoglycans	286:303	arg1	glycosaminoglycans					286:303	the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS)	282:346	the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS)	282:346	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	1	9	dep	glycosaminoglycans	286:303	arg1	HEP					314:316	HEP	314:316	HEP	314:316	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	7	10	theme	blood	1105:1109	arg1	coagulation					1111:1121	lower blood coagulation	1099:1121	lower blood coagulation	1099:1121	The whole-blood clotting kinetics assay also shows lower blood coagulation on TN-based PEMs.
32409070	11	11	theme	new	1569:1571	arg1	surfaces					1590:1597	new blood-compatible surfaces	1569:1597	new blood-compatible surfaces using a tannin derivative-based polymer	1569:1637	This study provides a new perspective for understanding platelet adhesion and activation on biomaterial surfaces, toward the development of new blood-compatible surfaces using a tannin derivative-based polymer.
32409070	4	12	theme	proteins	642:649	arg1	adsorption					612:621	the adsorption	608:621	the adsorption of key blood serum proteins, adhesion and activation of platelets,	608:688	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	4	12	theme	proteins	642:649	arg1	kinetics					709:716	blood clotting kinetics	694:716	blood clotting kinetics	694:716	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	11	13	theme	tannin	1607:1612	arg1	polymer					1631:1637	a tannin derivative-based polymer	1605:1637	a tannin derivative-based polymer	1605:1637	This study provides a new perspective for understanding platelet adhesion and activation on biomaterial surfaces, toward the development of new blood-compatible surfaces using a tannin derivative-based polymer.
32409070	9	14	theme	mussel	1291:1296	arg1	protein					1307:1313	mussel adhesive protein	1291:1313	mussel adhesive protein	1291:1313	It also contains catechol groups, which are similar to those in mussel adhesive protein.
32409070	5	15	with	association	859:869	arg1	groups					885:890	catechol groups	876:890	catechol groups	876:890	TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups.
32409070	6	16	theme	platelet	964:971	arg1	activation					973:982	platelet activation	964:982	platelet activation	964:982	However, TN-based PEMs significantly reduce both platelet adhesion and platelet activation, while CHI-based PEMs promote platelet adhesion and activation.
32409070	0	17	theme	serum	138:142	arg1	proteins					144:151	serum proteins	138:151	serum proteins	138:151	Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins.
32409070	9	18	theme	adhesive	1298:1305	arg1	protein					1307:1313	mussel adhesive protein	1291:1313	mussel adhesive protein	1291:1313	It also contains catechol groups, which are similar to those in mussel adhesive protein.
32409070	11	19	theme	surfaces	1590:1597	arg1	development					1554:1564	the development	1550:1564	the development of new blood-compatible surfaces using a tannin derivative-based polymer	1550:1637	This study provides a new perspective for understanding platelet adhesion and activation on biomaterial surfaces, toward the development of new blood-compatible surfaces using a tannin derivative-based polymer.
32409070	6	20	theme	platelet	1014:1021	arg1	adhesion					1023:1030	platelet adhesion	1014:1030	platelet adhesion	1014:1030	However, TN-based PEMs significantly reduce both platelet adhesion and platelet activation, while CHI-based PEMs promote platelet adhesion and activation.
32409070	11	21	theme	new	1451:1453	arg1	perspective					1455:1465	a new perspective	1449:1465	a new perspective for understanding platelet adhesion and activation on biomaterial surfaces	1449:1540	This study provides a new perspective for understanding platelet adhesion and activation on biomaterial surfaces, toward the development of new blood-compatible surfaces using a tannin derivative-based polymer.
32409070	1	22	theme	cationic	192:199	arg1	derivate					208:215	a cationic tannin derivate	190:215	a cationic tannin derivate (TN)	190:220	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	1	22	theme	cationic	192:199	arg1	TN					218:219	TN	218:219	TN	218:219	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	7	23	theme	lower	1099:1103	arg1	coagulation					1111:1121	lower blood coagulation	1099:1121	lower blood coagulation	1099:1121	The whole-blood clotting kinetics assay also shows lower blood coagulation on TN-based PEMs.
32409070	0	24	contain	containing	28:37	arg2	polyphenol					59:68	a tannin derivative polyphenol	39:68	a tannin derivative polyphenol	39:68	Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins.
32409070	0	24	contain	containing	28:37	arg1	multilayers					16:26	Polyelectrolyte multilayers	0:26	Polyelectrolyte multilayers containing a tannin derivative polyphenol	0:68	Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins.
32409070	0	25	theme	Polyelectrolyte	0:14	arg1	multilayers					16:26	Polyelectrolyte multilayers	0:26	Polyelectrolyte multilayers containing a tannin derivative polyphenol	0:68	Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins.
32409070	1	26	theme	tannin	201:206	arg1	derivate					208:215	a cationic tannin derivate	190:215	a cationic tannin derivate (TN)	190:220	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	1	26	theme	tannin	201:206	arg1	TN					218:219	TN	218:219	TN	218:219	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	2	27	theme	contact	450:456	arg1	measurements					464:475	water contact angle measurements	444:475	water contact angle measurements	444:475	The surface chemistry of the PEMs was characterized using X-ray photoelectron spectroscopy and water contact angle measurements.
32409070	4	28	theme	serum	636:640	arg1	proteins					642:649	key blood serum proteins	626:649	key blood serum proteins	626:649	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	4	28	theme	serum	636:640	arg1	activation					665:674	activation	665:674	activation of platelets	665:687	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	4	28	theme	serum	636:640	arg1	adhesion					652:659	adhesion	652:659	adhesion	652:659	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	11	29	from	adhesion	1494:1501	arg1	surfaces					1533:1540	biomaterial surfaces	1521:1540	biomaterial surfaces	1521:1540	This study provides a new perspective for understanding platelet adhesion and activation on biomaterial surfaces, toward the development of new blood-compatible surfaces using a tannin derivative-based polymer.
32409070	3	30	used	used	532:535	arg2	PEMs					478:481	PEMs	478:481	PEMs assembled with chitosan (CHI) and HEP or CS	478:525	PEMs assembled with chitosan (CHI) and HEP or CS were used as controls.
32409070	3	30	used	used	532:535	arg2	controls					540:547	controls	540:547	controls	540:547	PEMs assembled with chitosan (CHI) and HEP or CS were used as controls.
32409070	2	31	theme	water	444:448	arg1	measurements					464:475	water contact angle measurements	444:475	water contact angle measurements	444:475	The surface chemistry of the PEMs was characterized using X-ray photoelectron spectroscopy and water contact angle measurements.
32409070	6	32	theme	TN-based	902:909	arg1	PEMs					911:914	TN-based PEMs	902:914	TN-based PEMs	902:914	However, TN-based PEMs significantly reduce both platelet adhesion and platelet activation, while CHI-based PEMs promote platelet adhesion and activation.
32409070	11	33	theme	blood-compatible	1573:1588	arg1	surfaces					1590:1597	new blood-compatible surfaces	1569:1597	new blood-compatible surfaces using a tannin derivative-based polymer	1569:1637	This study provides a new perspective for understanding platelet adhesion and activation on biomaterial surfaces, toward the development of new blood-compatible surfaces using a tannin derivative-based polymer.
32409070	5	34	theme	fibrinogen	785:794	arg1	adsorption					796:805	fibrinogen adsorption	785:805	fibrinogen adsorption	785:805	TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups.
32409070	7	35	theme	clotting	1064:1071	arg1	assay					1082:1086	The whole-blood clotting kinetics assay	1048:1086	The whole-blood clotting kinetics assay	1048:1086	The whole-blood clotting kinetics assay also shows lower blood coagulation on TN-based PEMs.
32409070	10	36	theme	platelet-repelling	1402:1419	arg1	effect					1421:1426	the platelet-repelling effect	1398:1426	the platelet-repelling effect	1398:1426	These chemical features enable strong association with fibrinogen, which promotes the platelet-repelling effect.
32409070	8	37	theme	resonance	1205:1213	arg1	structures					1215:1224	resonance structures	1205:1224	resonance structures	1205:1224	TN is an amphoteric, cationic, condensed tannin derivative with resonance structures.
32409070	11	38	theme	platelet	1485:1492	arg1	adhesion					1494:1501	platelet adhesion	1485:1501	platelet adhesion	1485:1501	This study provides a new perspective for understanding platelet adhesion and activation on biomaterial surfaces, toward the development of new blood-compatible surfaces using a tannin derivative-based polymer.
32409070	2	39	theme	photoelectron	413:425	arg1	spectroscopy					427:438	X-ray photoelectron spectroscopy	407:438	X-ray photoelectron spectroscopy	407:438	The surface chemistry of the PEMs was characterized using X-ray photoelectron spectroscopy and water contact angle measurements.
32409070	8	40	theme	tannin	1182:1187	arg1	TN					1141:1142	TN	1141:1142	TN	1141:1142	TN is an amphoteric, cationic, condensed tannin derivative with resonance structures.
32409070	8	40	theme	tannin	1182:1187	arg1	derivative					1189:1198	an amphoteric, cationic, condensed tannin derivative	1147:1198	an amphoteric, cationic, condensed tannin derivative with resonance structures	1147:1224	TN is an amphoteric, cationic, condensed tannin derivative with resonance structures.
32409070	6	41	theme	platelet	942:949	arg1	adhesion					951:958	platelet adhesion	942:958	platelet adhesion	942:958	However, TN-based PEMs significantly reduce both platelet adhesion and platelet activation, while CHI-based PEMs promote platelet adhesion and activation.
32409070	7	42	theme	kinetics	1073:1080	arg1	assay					1082:1086	The whole-blood clotting kinetics assay	1048:1086	The whole-blood clotting kinetics assay	1048:1086	The whole-blood clotting kinetics assay also shows lower blood coagulation on TN-based PEMs.
32409070	2	43	theme	X-ray	407:411	arg1	spectroscopy					427:438	X-ray photoelectron spectroscopy	407:438	X-ray photoelectron spectroscopy	407:438	The surface chemistry of the PEMs was characterized using X-ray photoelectron spectroscopy and water contact angle measurements.
32409070	0	44	theme	derivative	48:57	arg1	polyphenol					59:68	a tannin derivative polyphenol	39:68	a tannin derivative polyphenol	39:68	Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins.
32409070	1	45	used	used	226:229	arg2	TN					218:219	TN	218:219	TN	218:219	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	1	45	used	used	226:229	arg2	derivate					208:215	a cationic tannin derivate	190:215	a cationic tannin derivate (TN)	190:220	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	4	46	theme	blood	630:634	arg1	proteins					642:649	key blood serum proteins	626:649	key blood serum proteins	626:649	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	4	46	theme	blood	630:634	arg1	activation					665:674	activation	665:674	activation of platelets	665:687	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	4	46	theme	blood	630:634	arg1	adhesion					652:659	adhesion	652:659	adhesion	652:659	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	0	47	theme	tannin	41:46	arg1	polyphenol					59:68	a tannin derivative polyphenol	39:68	a tannin derivative polyphenol	39:68	Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins.
32409070	7	48	theme	whole-blood	1052:1062	arg1	assay					1082:1086	The whole-blood clotting kinetics assay	1048:1086	The whole-blood clotting kinetics assay	1048:1086	The whole-blood clotting kinetics assay also shows lower blood coagulation on TN-based PEMs.
32409070	8	49	with	derivative	1189:1198	arg1	structures					1215:1224	resonance structures	1205:1224	resonance structures	1205:1224	TN is an amphoteric, cationic, condensed tannin derivative with resonance structures.
32409070	4	50	theme	key	626:628	arg1	proteins					642:649	key blood serum proteins	626:649	key blood serum proteins	626:649	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	4	50	theme	key	626:628	arg1	activation					665:674	activation	665:674	activation of platelets	665:687	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	4	50	theme	key	626:628	arg1	adhesion					652:659	adhesion	652:659	adhesion	652:659	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	5	51	theme	albumin	768:774	arg1	albumin					768:774	albumin	768:774	albumin	768:774	TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups.
32409070	5	51	theme	albumin	768:774	arg1	amounts					757:763	similar amounts	749:763	similar amounts of albumin	749:774	TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups.
32409070	5	52	theme	strong	852:857	arg1	association					859:869	strong association	852:869	strong association with catechol groups	852:890	TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups.
32409070	9	53	theme	catechol	1244:1251	arg1	groups					1253:1258	catechol groups	1244:1258	catechol groups	1244:1258	It also contains catechol groups, which are similar to those in mussel adhesive protein.
32409070	2	54	theme	angle	458:462	arg1	measurements					464:475	water contact angle measurements	444:475	water contact angle measurements	444:475	The surface chemistry of the PEMs was characterized using X-ray photoelectron spectroscopy and water contact angle measurements.
32409070	10	55	theme	chemical	1322:1329	arg1	features					1331:1338	These chemical features	1316:1338	These chemical features	1316:1338	These chemical features enable strong association with fibrinogen, which promotes the platelet-repelling effect.
32409070	8	56	dep	amphoteric	1150:1159	arg1	condensed					1172:1180	condensed	1172:1180	condensed	1172:1180	TN is an amphoteric, cationic, condensed tannin derivative with resonance structures.
32409070	8	56	dep	amphoteric	1150:1159	arg1	cationic					1162:1169	cationic	1162:1169	cationic	1162:1169	TN is an amphoteric, cationic, condensed tannin derivative with resonance structures.
32409070	1	57	theme	chondroitin	323:333	arg1	CS					344:345	CS	344:345	CS	344:345	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	1	57	theme	chondroitin	323:333	arg1	sulfate					335:341	chondroitin sulfate	323:341	chondroitin sulfate (CS)	323:346	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	1	57	theme	chondroitin	323:333	arg1	glycosaminoglycans					286:303	the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS)	282:346	the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS)	282:346	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	11	58	theme	derivative-based	1614:1629	arg1	polymer					1631:1637	a tannin derivative-based polymer	1605:1637	a tannin derivative-based polymer	1605:1637	This study provides a new perspective for understanding platelet adhesion and activation on biomaterial surfaces, toward the development of new blood-compatible surfaces using a tannin derivative-based polymer.
32409070	4	59	theme	clotting	700:707	arg1	kinetics					709:716	blood clotting kinetics	694:716	blood clotting kinetics	694:716	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	9	60	contain	contains	1235:1242	arg1	It					1227:1228	It	1227:1228	It	1227:1228	It also contains catechol groups, which are similar to those in mussel adhesive protein.
32409070	9	60	contain	contains	1235:1242	arg2	groups					1253:1258	catechol groups	1244:1258	catechol groups	1244:1258	It also contains catechol groups, which are similar to those in mussel adhesive protein.
32409070	5	61	theme	TN-	719:721	arg1	PEMs					737:740	TN- and CHI-based PEMs	719:740	TN- and CHI-based PEMs	719:740	TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups.
32409070	4	62	theme	blood	694:698	arg1	kinetics					709:716	blood clotting kinetics	694:716	blood clotting kinetics	694:716	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	4	63	theme	PEMs	590:593	arg1	hemocompatibility					569:585	the hemocompatibility	565:585	the hemocompatibility of PEMs	565:593	We investigate the hemocompatibility of PEMs by analyzing the adsorption of key blood serum proteins, adhesion and activation of platelets, and blood clotting kinetics.
32409070	5	64	theme	CHI-based	727:735	arg1	PEMs					737:740	TN- and CHI-based PEMs	719:740	TN- and CHI-based PEMs	719:740	TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups.
32409070	5	65	theme	TN-based	830:837	arg1	PEMs					839:842	TN-based PEMs	830:842	TN-based PEMs	830:842	TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups.
32409070	1	66	theme	hemocompatible	165:178	arg1	surfaces					180:187	hemocompatible surfaces	165:187	hemocompatible surfaces	165:187	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	2	67	theme	PEMs	378:381	arg1	chemistry					361:369	The surface chemistry	349:369	The surface chemistry of the PEMs	349:381	The surface chemistry of the PEMs was characterized using X-ray photoelectron spectroscopy and water contact angle measurements.
32409070	1	68	theme	polyelectrolyte	242:256	arg1	PEMs					271:274	PEMs	271:274	PEMs	271:274	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	1	68	theme	polyelectrolyte	242:256	arg1	multilayers					258:268	polyelectrolyte multilayers	242:268	polyelectrolyte multilayers (PEMs)	242:275	To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS).
32409070	0	69	theme	blood	78:82	arg1	compatibility					84:96	blood compatibility	78:96	blood compatibility	78:96	Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins.
32409070	10	70	with	association	1354:1364	arg1	fibrinogen					1371:1380	fibrinogen	1371:1380	fibrinogen	1371:1380	These chemical features enable strong association with fibrinogen, which promotes the platelet-repelling effect.
32409070	2	71	theme	surface	353:359	arg1	chemistry					361:369	The surface chemistry	349:369	The surface chemistry of the PEMs	349:381	The surface chemistry of the PEMs was characterized using X-ray photoelectron spectroscopy and water contact angle measurements.
32409070	6	72	theme	CHI-based	991:999	arg1	PEMs					1001:1004	CHI-based PEMs	991:1004	CHI-based PEMs	991:1004	However, TN-based PEMs significantly reduce both platelet adhesion and platelet activation, while CHI-based PEMs promote platelet adhesion and activation.
34284189	1	0	from	%	362:362	arg1	fixed					350:354	fixed	350:354	fixed	350:354	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
34284189	1	0	from	%	362:362	arg1	concentration					332:344	the casein concentration	321:344	the casein concentration	321:344	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
34284189	1	1	theme	MC/casein	296:304	arg1	systems					306:312	composite MC/casein systems	286:312	composite MC/casein systems	286:312	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
34284189	2	2	theme	water-in-water	580:593	arg1	"					613:613	a "water-in-water emulsion structure"	577:613	a "water-in-water emulsion structure"	577:613	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	2	3	theme	dispersed	683:691	arg1	phase					693:697	the dispersed phase	679:697	the dispersed phase	679:697	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	1	4	theme	gels	221:224	arg1	class					206:210	a class	204:210	a class of mixed gels	204:224	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
34284189	1	5	theme	systems	306:312	arg1	gelation					274:281	the gelation	270:281	the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v)	270:421	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
34284189	3	6	theme	determination	844:856	arg1	result					858:863	the determination result	840:863	the determination result of gel hardness	840:879	The structural conversion was in consistent with the determination result of gel hardness.
34284189	2	7	theme	%	728:728	arg1	w/v					731:733	0.4-1.0%, w/v	721:733	w/v	731:733	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	2	7	theme	%	728:728	arg1	addition					711:718	further MC addition	700:718	further MC addition (0.4-1.0%, w/v)	700:734	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	4	8	theme	gels	1028:1031	arg1	process					1007:1013	the structural evolution process	982:1013	the structural evolution process of the mixed gels	982:1031	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	2	9	theme	structural	517:526	arg1	conversion					528:537	a structural conversion	515:537	a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure"	515:613	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	4	10	theme	formation	1072:1080	arg1	mechanism					1082:1090	the underlying formation mechanism	1057:1090	the underlying formation mechanism of the mixed gels	1057:1108	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	4	11	theme	structural	986:995	arg1	process					1007:1013	the structural evolution process	982:1013	the structural evolution process of the mixed gels	982:1031	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	0	12	theme	formation	88:96	arg1	mechanism					98:106	formation mechanism	88:106	formation mechanism	88:106	Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.
34284189	1	13	theme	MC	378:379	arg1	concentration					381:393	the MC concentration	374:393	the MC concentration	374:393	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
34284189	2	14	dep	increasing	447:456	arg1	%					486:486	0-0.4%	481:486	0-0.4%	481:486	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	4	15	theme	underlying	1061:1070	arg1	mechanism					1082:1090	the underlying formation mechanism	1057:1090	the underlying formation mechanism of the mixed gels	1057:1108	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	1	16	theme	casein	325:330	arg1	fixed					350:354	fixed	350:354	fixed	350:354	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
34284189	1	16	theme	casein	325:330	arg1	concentration					332:344	the casein concentration	321:344	the casein concentration	321:344	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
34284189	2	17	theme	mixed	494:498	arg1	gels					500:503	the mixed gels	490:503	the mixed gels	490:503	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	2	18	theme	gel	562:564	arg1	network					566:572	a casein-dominant gel network	544:572	a casein-dominant gel network	544:572	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	1	19	dep	1.0	412:414	arg1	to					409:410	to	409:410	to	409:410	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
34284189	2	20	from	network	566:572	arg1	conversion					528:537	a structural conversion	515:537	a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure"	515:613	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	0	21	theme	mixed	13:17	arg1	gels					46:49	Acid-induced mixed methylcellulose and casein gels	0:49	Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.	0:107	Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.
34284189	2	22	theme	casein-dominant	546:560	arg1	network					566:572	a casein-dominant gel network	544:572	a casein-dominant gel network	544:572	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	4	23	theme	rheological	961:971	arg1	studies					973:979	rheological studies	961:979	rheological studies	961:979	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	0	24	theme	Acid-induced	0:11	arg1	gels					46:49	Acid-induced mixed methylcellulose and casein gels	0:49	Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.	0:107	Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.
34284189	2	25	theme	gelling	651:657	arg1	phase					659:663	the continuous gelling phase	636:663	the continuous gelling phase	636:663	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	3	26	theme	gel	868:870	arg1	hardness					872:879	gel hardness	868:879	gel hardness	868:879	The structural conversion was in consistent with the determination result of gel hardness.
34284189	2	27	theme	continuous	640:649	arg1	phase					659:663	the continuous gelling phase	636:663	the continuous gelling phase	636:663	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	1	28	theme	building	174:181	arg1	materials					183:191	building materials	174:191	building materials	174:191	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
34284189	1	28	theme	building	174:181	arg1	caseins					124:130	caseins	124:130	caseins	124:130	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
34284189	1	28	theme	building	174:181	arg1	methylcellulose					136:150	methylcellulose	136:150	methylcellulose (MC)	136:155	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
34284189	0	29	theme	methylcellulose	19:33	arg1	gels					46:49	Acid-induced mixed methylcellulose and casein gels	0:49	Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.	0:107	Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.
34284189	4	30	theme	microscope	939:948	arg1	combination					900:910	a combination	898:910	a combination of confocal laser scanning microscope (CLSM)	898:955	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	4	30	theme	microscope	939:948	arg1	studies					973:979	rheological studies	961:979	rheological studies	961:979	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	4	31	theme	gels	1105:1108	arg1	mechanism					1082:1090	the underlying formation mechanism	1057:1090	the underlying formation mechanism of the mixed gels	1057:1108	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	0	32	theme	casein	39:44	arg1	gels					46:49	Acid-induced mixed methylcellulose and casein gels	0:49	Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.	0:107	Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.
34284189	2	33	theme	separation	768:777	arg1	phenomenon					779:788	a more significant phase separation phenomenon	743:788	a more significant phase separation phenomenon	743:788	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	2	34	theme	phase	762:766	arg1	phenomenon					779:788	a more significant phase separation phenomenon	743:788	a more significant phase separation phenomenon	743:788	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	2	35	theme	addition	471:478	arg1	amount					458:463	amount	458:463	amount of MC addition	458:478	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	2	35	theme	addition	471:478	arg1	addition					471:478	MC addition	468:478	MC addition	468:478	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	0	36	dep	gels	46:49	arg1	properties					73:82	physical properties	64:82	physical properties	64:82	Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.
34284189	0	36	dep	gels	46:49	arg1	mechanism					98:106	formation mechanism	88:106	formation mechanism	88:106	Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.
34284189	0	36	dep	gels	46:49	arg1	Structures					52:61	Structures	52:61	Structures	52:61	Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.
34284189	3	37	theme	structural	795:804	arg1	conversion					806:815	The structural conversion	791:815	The structural conversion	791:815	The structural conversion was in consistent with the determination result of gel hardness.
34284189	3	37	theme	structural	795:804	arg1	consistent					824:833	consistent	824:833	consistent	824:833	The structural conversion was in consistent with the determination result of gel hardness.
34284189	2	38	theme	significant	750:760	arg1	phenomenon					779:788	a more significant phase separation phenomenon	743:788	a more significant phase separation phenomenon	743:788	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	2	39	theme	MC	468:469	arg1	addition					471:478	MC addition	468:478	MC addition	468:478	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	4	40	theme	mixed	1022:1026	arg1	gels					1028:1031	the mixed gels	1018:1031	the mixed gels	1018:1031	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	3	41	theme	hardness	872:879	arg1	result					858:863	the determination result	840:863	the determination result of gel hardness	840:879	The structural conversion was in consistent with the determination result of gel hardness.
34284189	4	42	theme	evolution	997:1005	arg1	process					1007:1013	the structural evolution process	982:1013	the structural evolution process of the mixed gels	982:1031	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	4	43	theme	mixed	1099:1103	arg1	gels					1105:1108	the mixed gels	1095:1108	the mixed gels	1095:1108	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	4	44	theme	scanning	930:937	arg1	CLSM					951:954	CLSM	951:954	CLSM	951:954	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	4	44	theme	scanning	930:937	arg1	microscope					939:948	confocal laser scanning microscope	915:948	confocal laser scanning microscope (CLSM)	915:955	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	4	45	theme	laser	924:928	arg1	CLSM					951:954	CLSM	951:954	CLSM	951:954	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	4	45	theme	laser	924:928	arg1	microscope					939:948	confocal laser scanning microscope	915:948	confocal laser scanning microscope (CLSM)	915:955	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	2	46	theme	MC	708:709	arg1	w/v					731:733	0.4-1.0%, w/v	721:733	w/v	731:733	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	2	46	theme	MC	708:709	arg1	addition					711:718	further MC addition	700:718	further MC addition (0.4-1.0%, w/v)	700:734	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	0	47	theme	physical	64:71	arg1	properties					73:82	physical properties	64:82	physical properties	64:82	Acid-induced mixed methylcellulose and casein gels: Structures, physical properties and formation mechanism.
34284189	2	48	theme	structure	604:612	arg1	"					613:613	a "water-in-water emulsion structure"	577:613	a "water-in-water emulsion structure"	577:613	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	4	49	theme	confocal	915:922	arg1	CLSM					951:954	CLSM	951:954	CLSM	951:954	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	4	49	theme	confocal	915:922	arg1	microscope					939:948	confocal laser scanning microscope	915:948	confocal laser scanning microscope (CLSM)	915:955	Furthermore, by a combination of confocal laser scanning microscope (CLSM) and rheological studies, the structural evolution process of the mixed gels was revealed to explore the underlying formation mechanism of the mixed gels.
34284189	2	50	theme	further	700:706	arg1	w/v					731:733	0.4-1.0%, w/v	721:733	w/v	731:733	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	2	50	theme	further	700:706	arg1	addition					711:718	further MC addition	700:718	further MC addition (0.4-1.0%, w/v)	700:734	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	1	51	theme	composite	286:294	arg1	systems					306:312	composite MC/casein systems	286:312	composite MC/casein systems	286:312	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
34284189	3	52	with	consistent	824:833	arg1	result					858:863	the determination result	840:863	the determination result of gel hardness	840:879	The structural conversion was in consistent with the determination result of gel hardness.
34284189	2	53	theme	emulsion	595:602	arg1	"					613:613	a "water-in-water emulsion structure"	577:613	a "water-in-water emulsion structure"	577:613	It was found that with increasing amount of MC addition (0-0.4%), the mixed gels exhibited a structural conversion from a casein-dominant gel network to a "water-in-water emulsion structure", with the caseins as the continuous gelling phase and the MC as the dispersed phase; further MC addition (0.4-1.0%, w/v) caused a more significant phase separation phenomenon.
34284189	1	54	theme	mixed	215:219	arg1	gels					221:224	mixed gels	215:224	mixed gels	215:224	In this study, caseins and methylcellulose (MC) were selected as building materials to prepare a class of mixed gels by adding glucono-δ-lactone (GDL) to induce the gelation of composite MC/casein systems, where the casein concentration was fixed at 8.0% (w/v) and the MC concentration varied from 0 to 1.0% (w/v).
35074117	0	0	theme	peripheral	104:113	arg1	repair					121:126	peripheral nerve repair	104:126	peripheral nerve repair	104:126	In-situ self-assembly of bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers for peripheral nerve repair.
35074117	6	1	theme	peripheral	1010:1019	arg1	repair					1027:1032	the peripheral nerve repair	1006:1032	the peripheral nerve repair effect	1006:1039	Furthermore, nerve conduits made of BPS were implanted in-vivo for 12 weeks, and it great improved the peripheral nerve repair effect.
35074117	7	2	theme	cells	1120:1124	arg1	loading					1126:1132	cells loading	1120:1132	cells loading	1120:1132	In summary, BPS membranes with excellent conductivity and multiple merits for cells loading, hold great application potential for peripheral nerve repair.
35074117	6	3	theme	nerve	920:924	arg1	conduits					926:933	nerve conduits	920:933	nerve conduits made of BPS	920:945	Furthermore, nerve conduits made of BPS were implanted in-vivo for 12 weeks, and it great improved the peripheral nerve repair effect.
35074117	3	4	theme	PEDOT	565:569	arg1	doping					579:584	the doping	575:584	the doping of SNFs	575:592	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	3	4	theme	PEDOT	565:569	arg1	polymerization					547:560	the in-situ polymerization	535:560	the in-situ polymerization of PEDOT	535:569	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	3	5	theme	SNFs	589:592	arg1	doping					579:584	the doping	575:584	the doping of SNFs	575:592	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	3	5	theme	SNFs	589:592	arg1	polymerization					547:560	the in-situ polymerization	535:560	the in-situ polymerization of PEDOT	535:569	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	4	6	link	adipose-derived	725:739	arg1	cells					746:750	adipose-derived stem cells	725:750	adipose-derived stem cells (ADSCs)	725:758	The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs).
35074117	4	6	link	adipose-derived	725:739	arg1	ADSCs					753:757	ADSCs	753:757	ADSCs	753:757	The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs).
35074117	3	7	theme	transparent	385:395	arg1	BC/PEDOT-SNFs					473:485	BC/PEDOT-SNFs	473:485	BC/PEDOT-SNFs	473:485	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	3	7	theme	transparent	385:395	arg1	nanofibers					461:470	transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers	385:470	transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS)	385:491	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	4	8	theme	cells	746:750	arg1	proliferation					708:720	proliferation	708:720	proliferation	708:720	The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs).
35074117	4	8	theme	cells	746:750	arg1	adhesion					695:702	adhesion	695:702	adhesion	695:702	The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs).
35074117	1	9	theme	nerve	208:212	arg1	repair					214:219	peripheral nerve repair	197:219	peripheral nerve repair	197:219	Biocompatible and electroactive biomaterials have good potential on peripheral nerve repair.
35074117	7	10	theme	multiple	1100:1107	arg1	merits					1109:1114	multiple merits	1100:1114	multiple merits	1100:1114	In summary, BPS membranes with excellent conductivity and multiple merits for cells loading, hold great application potential for peripheral nerve repair.
35074117	0	11	theme	In-situ	0:6	arg1	self-assembly					8:20	In-situ self-assembly	0:20	In-situ self-assembly of bacterial cellulose/poly(3,4-ethylenedioxythiophene)	0:76	In-situ self-assembly of bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers for peripheral nerve repair.
35074117	5	12	theme	BPS	781:783	arg1	conductivity					765:776	The conductivity	761:776	The conductivity of BPS	761:783	The conductivity of BPS was affected by the SNFs doped, and its value was up to 1.8 × 10-2 S/cm while the sulfonation degree of SNFs reached 93%.
35074117	7	13	theme	peripheral	1172:1181	arg1	repair					1189:1194	peripheral nerve repair	1172:1194	peripheral nerve repair	1172:1194	In summary, BPS membranes with excellent conductivity and multiple merits for cells loading, hold great application potential for peripheral nerve repair.
35074117	7	14	theme	excellent	1073:1081	arg1	conductivity					1083:1094	excellent conductivity	1073:1094	excellent conductivity	1073:1094	In summary, BPS membranes with excellent conductivity and multiple merits for cells loading, hold great application potential for peripheral nerve repair.
35074117	5	15	theme	SNFs	889:892	arg1	degree					879:884	the sulfonation degree	863:884	the sulfonation degree of SNFs	863:892	The conductivity of BPS was affected by the SNFs doped, and its value was up to 1.8 × 10-2 S/cm while the sulfonation degree of SNFs reached 93%.
35074117	3	16	theme	3,4-ethylenedioxythiophene	422:447	arg1	BC/PEDOT-SNFs					473:485	BC/PEDOT-SNFs	473:485	BC/PEDOT-SNFs	473:485	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	3	16	theme	3,4-ethylenedioxythiophene	422:447	arg1	nanofibers					461:470	transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers	385:470	transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS)	385:491	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	7	17	theme	BPS	1054:1056	arg1	membranes					1058:1066	BPS membranes	1054:1066	BPS membranes	1054:1066	In summary, BPS membranes with excellent conductivity and multiple merits for cells loading, hold great application potential for peripheral nerve repair.
35074117	0	18	theme	bacterial	25:33	arg1	3,4-ethylenedioxythiophene					50:75	3,4-ethylenedioxythiophene	50:75	3,4-ethylenedioxythiophene	50:75	In-situ self-assembly of bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers for peripheral nerve repair.
35074117	0	18	theme	bacterial	25:33	arg1	cellulose/poly					35:48	bacterial cellulose/poly	25:48	bacterial cellulose/poly(3,4-ethylenedioxythiophene)	25:76	In-situ self-assembly of bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers for peripheral nerve repair.
35074117	7	19	with	membranes	1058:1066	arg1	conductivity					1083:1094	excellent conductivity	1073:1094	excellent conductivity	1073:1094	In summary, BPS membranes with excellent conductivity and multiple merits for cells loading, hold great application potential for peripheral nerve repair.
35074117	7	19	with	membranes	1058:1066	arg1	merits					1109:1114	multiple merits	1100:1114	multiple merits	1100:1114	In summary, BPS membranes with excellent conductivity and multiple merits for cells loading, hold great application potential for peripheral nerve repair.
35074117	4	20	theme	conducive	678:686	arg1	membranes					668:676	the BPS membranes	660:676	the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs)	660:758	The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs).
35074117	3	21	theme	cellulose/poly	407:420	arg1	BC/PEDOT-SNFs					473:485	BC/PEDOT-SNFs	473:485	BC/PEDOT-SNFs	473:485	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	3	21	theme	cellulose/poly	407:420	arg1	nanofibers					461:470	transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers	385:470	transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS)	385:491	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	4	22	theme	PEDOT	617:621	arg1	polymerization					599:612	The polymerization	595:612	The polymerization of PEDOT	595:621	The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs).
35074117	2	23	theme	Bacterial	222:230	arg1	BC					243:244	BC	243:244	BC	243:244	Bacterial cellulose (BC) shows excellent biocompatibility and is easy to modified, however it lacks electroactivity.
35074117	2	23	theme	Bacterial	222:230	arg1	cellulose					232:240	Bacterial cellulose	222:240	Bacterial cellulose (BC)	222:245	Bacterial cellulose (BC) shows excellent biocompatibility and is easy to modified, however it lacks electroactivity.
35074117	1	24	theme	peripheral	197:206	arg1	repair					214:219	peripheral nerve repair	197:219	peripheral nerve repair	197:219	Biocompatible and electroactive biomaterials have good potential on peripheral nerve repair.
35074117	4	25	theme	stem	741:744	arg1	cells					746:750	adipose-derived stem cells	725:750	adipose-derived stem cells (ADSCs)	725:758	The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs).
35074117	4	25	theme	stem	741:744	arg1	ADSCs					753:757	ADSCs	753:757	ADSCs	753:757	The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs).
35074117	7	26	theme	great	1140:1144	arg1	potential					1158:1166	great application potential	1140:1166	great application potential for peripheral nerve repair	1140:1194	In summary, BPS membranes with excellent conductivity and multiple merits for cells loading, hold great application potential for peripheral nerve repair.
35074117	3	27	dep	biocompatible	354:366	arg1	membranes					503:511	composite membranes	493:511	composite membranes	493:511	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	7	28	theme	nerve	1183:1187	arg1	repair					1189:1194	peripheral nerve repair	1172:1194	peripheral nerve repair	1172:1194	In summary, BPS membranes with excellent conductivity and multiple merits for cells loading, hold great application potential for peripheral nerve repair.
35074117	3	29	dep	BC/PEDOT-SNFs	473:485	arg1	BPS					488:490	BPS	488:490	BPS	488:490	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	3	30	theme	composite	493:501	arg1	membranes					503:511	composite membranes	493:511	composite membranes	493:511	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	0	31	theme	cellulose/poly	35:48	arg1	self-assembly					8:20	In-situ self-assembly	0:20	In-situ self-assembly of bacterial cellulose/poly(3,4-ethylenedioxythiophene)	0:76	In-situ self-assembly of bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers for peripheral nerve repair.
35074117	7	32	theme	application	1146:1156	arg1	potential					1158:1166	great application potential	1140:1166	great application potential for peripheral nerve repair	1140:1194	In summary, BPS membranes with excellent conductivity and multiple merits for cells loading, hold great application potential for peripheral nerve repair.
35074117	3	33	theme	bacterial	397:405	arg1	BC/PEDOT-SNFs					473:485	BC/PEDOT-SNFs	473:485	BC/PEDOT-SNFs	473:485	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	3	33	theme	bacterial	397:405	arg1	nanofibers					461:470	transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers	385:470	transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS)	385:491	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	5	34	theme	sulfonation	867:877	arg1	degree					879:884	the sulfonation degree	863:884	the sulfonation degree of SNFs	863:892	The conductivity of BPS was affected by the SNFs doped, and its value was up to 1.8 × 10-2 S/cm while the sulfonation degree of SNFs reached 93%.
35074117	2	35	theme	excellent	253:261	arg1	biocompatibility					263:278	excellent biocompatibility	253:278	excellent biocompatibility	253:278	Bacterial cellulose (BC) shows excellent biocompatibility and is easy to modified, however it lacks electroactivity.
35074117	3	36	theme	in-situ	539:545	arg1	polymerization					547:560	the in-situ polymerization	535:560	the in-situ polymerization of PEDOT	535:569	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	3	37	theme	-sulfonated	449:459	arg1	BC/PEDOT-SNFs					473:485	BC/PEDOT-SNFs	473:485	BC/PEDOT-SNFs	473:485	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	3	37	theme	-sulfonated	449:459	arg1	nanofibers					461:470	transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers	385:470	transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS)	385:491	In this study, biocompatible, conductive, and transparent bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers (BC/PEDOT-SNFs, BPS) composite membranes were prepared through the in-situ polymerization of PEDOT and the doping of SNFs.
35074117	4	38	dep	adhesion	695:702	arg1	the					691:693	the	691:693	the	691:693	The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs).
35074117	6	39	theme	repair	1027:1032	arg1	effect					1034:1039	the peripheral nerve repair effect	1006:1039	the peripheral nerve repair effect	1006:1039	Furthermore, nerve conduits made of BPS were implanted in-vivo for 12 weeks, and it great improved the peripheral nerve repair effect.
35074117	4	40	theme	adipose-derived	725:739	arg1	cells					746:750	adipose-derived stem cells	725:750	adipose-derived stem cells (ADSCs)	725:758	The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs).
35074117	4	40	theme	adipose-derived	725:739	arg1	ADSCs					753:757	ADSCs	753:757	ADSCs	753:757	The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs).
35074117	6	41	theme	nerve	1021:1025	arg1	repair					1027:1032	the peripheral nerve repair	1006:1032	the peripheral nerve repair effect	1006:1039	Furthermore, nerve conduits made of BPS were implanted in-vivo for 12 weeks, and it great improved the peripheral nerve repair effect.
35074117	5	42	dep	1.8 × 10-2 S/cm	841:855	arg1	to					838:839	to	838:839	to	838:839	The conductivity of BPS was affected by the SNFs doped, and its value was up to 1.8 × 10-2 S/cm while the sulfonation degree of SNFs reached 93%.
35074117	1	43	theme	good	179:182	arg1	potential					184:192	good potential	179:192	good potential	179:192	Biocompatible and electroactive biomaterials have good potential on peripheral nerve repair.
35074117	4	44	theme	BPS	664:666	arg1	membranes					668:676	the BPS membranes	660:676	the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs)	660:758	The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs).
35074117	1	45	contain	have	174:177	arg2	potential					184:192	good potential	179:192	good potential	179:192	Biocompatible and electroactive biomaterials have good potential on peripheral nerve repair.
35074117	1	45	contain	have	174:177	arg1	electroactive					147:159	electroactive	147:159	electroactive	147:159	Biocompatible and electroactive biomaterials have good potential on peripheral nerve repair.
35074117	1	45	contain	have	174:177	arg1	Biocompatible					129:141	Biocompatible	129:141	Biocompatible	129:141	Biocompatible and electroactive biomaterials have good potential on peripheral nerve repair.
35074117	4	46	with	endowed	623:629	arg1	conductivity					639:650	conductivity	639:650	conductivity	639:650	The polymerization of PEDOT endowed BC with conductivity, making the BPS membranes conducive to the adhesion and proliferation of adipose-derived stem cells (ADSCs).
35074117	1	47	dep	Biocompatible	129:141	arg1	biomaterials					161:172	biomaterials	161:172	biomaterials	161:172	Biocompatible and electroactive biomaterials have good potential on peripheral nerve repair.
35074117	0	48	theme	nerve	115:119	arg1	repair					121:126	peripheral nerve repair	104:126	peripheral nerve repair	104:126	In-situ self-assembly of bacterial cellulose/poly(3,4-ethylenedioxythiophene)-sulfonated nanofibers for peripheral nerve repair.
33058153	7	0	theme	WPI	1456:1458	arg1	quantity					1460:1467	the WPI quantity	1452:1467	the WPI quantity	1452:1467	The α-relaxation temperature of the amorphous samples decreased due to water plasticization, but increased with an increase in the WPI quantity.
33058153	2	1	dep	processability	177:190	arg1	the					173:175	the	173:175	the	173:175	To understand the processability and stability of maltose-containing foods, material characterization of the phase and state transition from its amorphous state is required.
33058153	10	2	theme	Chemical	1879:1886	arg1	Industry					1888:1895	Chemical Industry	1879:1895	Chemical Industry	1879:1895	© 2020 Society of Chemical Industry.
33058153	8	3	theme	WLF	1641:1643	arg1	equation					1646:1653	the William-Landel-Ferry (WLF) equation	1615:1653	the William-Landel-Ferry (WLF) equation	1615:1653	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility, was based on the William-Landel-Ferry (WLF) equation.
33058153	4	4	located	observed	856:863	arg2	factor					646:651	the corresponding time factor	623:651	the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures	623:850	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	4	located	observed	856:863	arg2	sorption					566:573	water sorption	560:573	water sorption	560:573	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	4	located	observed	856:863	arg2	crystallization					576:590	crystallization	576:590	crystallization	576:590	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	4	located	observed	856:863	arg2	α-relaxation					605:616	Tg -related α-relaxation	593:616	Tg -related α-relaxation	593:616	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	4	located	observed	856:863	arg1	level					896:900	the molecular level	882:900	the molecular level	882:900	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	4	located	observed	856:863	arg1	study					553:557	this study	548:557	this study	548:557	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	4	located	observed	856:863	arg1	aw					868:869	aw ≤ 0.440	868:877	aw ≤ 0.440	868:877	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	2	5	theme	amorphous	304:312	arg1	state					314:318	its amorphous state	300:318	its amorphous state	300:318	To understand the processability and stability of maltose-containing foods, material characterization of the phase and state transition from its amorphous state is required.
33058153	6	6	theme	Gordon-Taylor	1221:1233	arg1	model					1235:1239	the Gordon-Taylor model	1217:1239	the Gordon-Taylor model	1217:1239	The relationship between Tg and the water content was fitted by the Gordon-Taylor model, and its constant showed a compositional dependence for the maltose / WPI mixtures.
33058153	9	7	dep	CONCLUSION	1656:1665	arg1	exhibits					1681:1688	exhibits	1681:1688	exhibits considerable potential for application in controlling the crystallization of amorphous maltose and improving the processability and stability of maltose-containing foods	1681:1858	CONCLUSION The S concept exhibits considerable potential for application in controlling the crystallization of amorphous maltose and improving the processability and stability of maltose-containing foods.
33058153	4	8	theme	protein	694:700	arg1	mixtures					716:723	whey protein isolate (WPI) mixtures	689:723	whey protein isolate (WPI) mixtures	689:723	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	7	9	theme	amorphous	1361:1369	arg1	samples					1371:1377	the amorphous samples	1357:1377	the amorphous samples	1357:1377	The α-relaxation temperature of the amorphous samples decreased due to water plasticization, but increased with an increase in the WPI quantity.
33058153	4	10	theme	amorphous	657:665	arg1	maltose					667:673	amorphous maltose	657:673	amorphous maltose	657:673	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	6	11	theme	maltose	1301:1307	arg1	mixtures					1315:1322	the maltose / WPI mixtures	1297:1322	the maltose / WPI mixtures	1297:1322	The relationship between Tg and the water content was fitted by the Gordon-Taylor model, and its constant showed a compositional dependence for the maltose / WPI mixtures.
33058153	8	12	dep	quantitative	1528:1539	arg1	estimate					1541:1548	estimate	1541:1548	estimate	1541:1548	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility, was based on the William-Landel-Ferry (WLF) equation.
33058153	7	13	from	increase	1440:1447	arg1	quantity					1460:1467	the WPI quantity	1452:1467	the WPI quantity	1452:1467	The α-relaxation temperature of the amorphous samples decreased due to water plasticization, but increased with an increase in the WPI quantity.
33058153	8	14	theme	effects	1571:1577	arg1	maltose					1507:1513	amorphous maltose	1497:1513	amorphous maltose	1497:1513	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility, was based on the William-Landel-Ferry (WLF) equation.
33058153	8	14	theme	effects	1571:1577	arg1	quantitative					1528:1539	quantitative	1528:1539	quantitative	1528:1539	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility, was based on the William-Landel-Ferry (WLF) equation.
33058153	4	15	theme	molecular	886:894	arg1	level					896:900	the molecular level	882:900	the molecular level	882:900	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	7	16	theme	α-relaxation	1329:1340	arg1	temperature					1342:1352	The α-relaxation temperature	1325:1352	The α-relaxation temperature of the amorphous samples	1325:1377	The α-relaxation temperature of the amorphous samples decreased due to water plasticization, but increased with an increase in the WPI quantity.
33058153	6	17	theme	compositional	1268:1280	arg1	dependence					1282:1291	a compositional dependence	1266:1291	a compositional dependence for the maltose / WPI mixtures	1266:1322	The relationship between Tg and the water content was fitted by the Gordon-Taylor model, and its constant showed a compositional dependence for the maltose / WPI mixtures.
33058153	2	18	theme	material	235:242	arg1	characterization					244:259	material characterization	235:259	material characterization of the phase and state transition from its amorphous state	235:318	To understand the processability and stability of maltose-containing foods, material characterization of the phase and state transition from its amorphous state is required.
33058153	1	19	theme	essential	127:135	arg1	derivative					137:146	an essential derivative	124:146	an essential derivative of starch	124:156	BACKGROUND Maltose is an essential derivative of starch.
33058153	1	19	theme	essential	127:135	arg1	Maltose					113:119	BACKGROUND Maltose	102:119	BACKGROUND Maltose	102:119	BACKGROUND Maltose is an essential derivative of starch.
33058153	8	20	from	effects	1571:1577	arg1	mobility					1592:1599	molecular mobility	1582:1599	molecular mobility	1582:1599	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility, was based on the William-Landel-Ferry (WLF) equation.
33058153	5	21	theme	amorphous	1043:1051	arg1	maltose					1053:1059	amorphous maltose	1043:1059	amorphous maltose	1043:1059	The crystal formation and crystallization kinetics of amorphous maltose were affected by water and WPI at aw ≥ 0.534 and 25 °C, as determined by X-ray diffraction.
33058153	2	22	theme	state	278:282	arg1	transition					284:293	the phase and state transition	264:293	transition	284:293	To understand the processability and stability of maltose-containing foods, material characterization of the phase and state transition from its amorphous state is required.
33058153	2	23	from	state	314:318	arg1	characterization					244:259	material characterization	235:259	material characterization of the phase and state transition from its amorphous state	235:318	To understand the processability and stability of maltose-containing foods, material characterization of the phase and state transition from its amorphous state is required.
33058153	2	23	from	state	314:318	arg1	transition					284:293	the phase and state transition	264:293	transition	284:293	To understand the processability and stability of maltose-containing foods, material characterization of the phase and state transition from its amorphous state is required.
33058153	9	24	theme	considerable	1690:1701	arg1	potential					1703:1711	considerable potential	1690:1711	considerable potential for application	1690:1727	CONCLUSION The S concept exhibits considerable potential for application in controlling the crystallization of amorphous maltose and improving the processability and stability of maltose-containing foods.
33058153	0	25	theme	maltose/whey	63:74	arg1	mixtures					92:99	maltose/whey protein isolate mixtures	63:99	maltose/whey protein isolate mixtures	63:99	Crystallization and strength analysis of amorphous maltose and maltose/whey protein isolate mixtures.
33058153	2	26	theme	phase	268:272	arg1	transition					284:293	the phase and state transition	264:293	transition	284:293	To understand the processability and stability of maltose-containing foods, material characterization of the phase and state transition from its amorphous state is required.
33058153	0	27	theme	isolate	84:90	arg1	mixtures					92:99	maltose/whey protein isolate mixtures	63:99	maltose/whey protein isolate mixtures	63:99	Crystallization and strength analysis of amorphous maltose and maltose/whey protein isolate mixtures.
33058153	4	28	theme	maltose	944:950	arg1	crystallization					915:929	the crystallization	911:929	the crystallization of amorphous maltose	911:950	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	2	29	from	characterization	244:259	arg1	state					314:318	its amorphous state	300:318	its amorphous state	300:318	To understand the processability and stability of maltose-containing foods, material characterization of the phase and state transition from its amorphous state is required.
33058153	3	30	theme	maltose	375:381	arg1	crystallization					346:360	the crystallization	342:360	the crystallization of amorphous maltose	342:381	Although the crystallization of amorphous maltose is well understood, few studies have reported the relationship between the crystallization and the glass transition temperature (Tg )-related molecular mobility.
33058153	6	31	theme	WPI	1311:1313	arg1	mixtures					1315:1322	the maltose / WPI mixtures	1297:1322	the maltose / WPI mixtures	1297:1322	The relationship between Tg and the water content was fitted by the Gordon-Taylor model, and its constant showed a compositional dependence for the maltose / WPI mixtures.
33058153	4	32	theme	aw	969:970	arg1	≥0.534					980:985	≥0.534	980:985	≥0.534	980:985	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	32	theme	aw	969:970	arg1	values					972:977	high aw values	964:977	high aw values (≥0.534)	964:986	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	33	theme	water	749:753	arg1	levels					770:775	various water activity (aw ) levels	741:775	various water activity (aw ) levels	741:775	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	1	34	theme	BACKGROUND	102:111	arg1	derivative					137:146	an essential derivative	124:146	an essential derivative of starch	124:156	BACKGROUND Maltose is an essential derivative of starch.
33058153	1	34	theme	BACKGROUND	102:111	arg1	Maltose					113:119	BACKGROUND Maltose	102:119	BACKGROUND Maltose	102:119	BACKGROUND Maltose is an essential derivative of starch.
33058153	9	35	theme	maltose	1777:1783	arg1	crystallization					1748:1762	the crystallization	1744:1762	the crystallization of amorphous maltose	1744:1783	CONCLUSION The S concept exhibits considerable potential for application in controlling the crystallization of amorphous maltose and improving the processability and stability of maltose-containing foods.
33058153	0	36	theme	strength	20:27	arg1	analysis					29:36	strength analysis	20:36	strength analysis	20:36	Crystallization and strength analysis of amorphous maltose and maltose/whey protein isolate mixtures.
33058153	3	37	theme	glass	482:486	arg1	Tg					512:513	Tg	512:513	Tg	512:513	Although the crystallization of amorphous maltose is well understood, few studies have reported the relationship between the crystallization and the glass transition temperature (Tg )-related molecular mobility.
33058153	3	37	theme	glass	482:486	arg1	temperature					499:509	the glass transition temperature	478:509	the glass transition temperature (Tg )	478:515	Although the crystallization of amorphous maltose is well understood, few studies have reported the relationship between the crystallization and the glass transition temperature (Tg )-related molecular mobility.
33058153	5	38	theme	formation	1001:1009	arg1	kinetics					1031:1038	The crystal formation and crystallization kinetics	989:1038	The crystal formation and crystallization kinetics of amorphous maltose	989:1059	The crystal formation and crystallization kinetics of amorphous maltose were affected by water and WPI at aw ≥ 0.534 and 25 °C, as determined by X-ray diffraction.
33058153	4	39	theme	high	964:967	arg1	≥0.534					980:985	≥0.534	980:985	≥0.534	980:985	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	39	theme	high	964:967	arg1	values					972:977	high aw values	964:977	high aw values (≥0.534)	964:986	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	3	40	theme	-related	516:523	arg1	mobility					535:542	-related molecular mobility	516:542	-related molecular mobility	516:542	Although the crystallization of amorphous maltose is well understood, few studies have reported the relationship between the crystallization and the glass transition temperature (Tg )-related molecular mobility.
33058153	0	41	theme	maltose	51:57	arg1	Crystallization					0:14	Crystallization	0:14	Crystallization	0:14	Crystallization and strength analysis of amorphous maltose and maltose/whey protein isolate mixtures.
33058153	0	41	theme	maltose	51:57	arg1	analysis					29:36	strength analysis	20:36	strength analysis	20:36	Crystallization and strength analysis of amorphous maltose and maltose/whey protein isolate mixtures.
33058153	5	42	theme	crystallization	1015:1029	arg1	kinetics					1031:1038	The crystal formation and crystallization kinetics	989:1038	The crystal formation and crystallization kinetics of amorphous maltose	989:1059	The crystal formation and crystallization kinetics of amorphous maltose were affected by water and WPI at aw ≥ 0.534 and 25 °C, as determined by X-ray diffraction.
33058153	4	43	theme	water	560:564	arg1	sorption					566:573	water sorption	560:573	water sorption	560:573	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	2	44	theme	foods	228:232	arg1	stability					196:204	stability	196:204	stability	196:204	To understand the processability and stability of maltose-containing foods, material characterization of the phase and state transition from its amorphous state is required.
33058153	2	44	theme	foods	228:232	arg1	processability					177:190	processability	177:190	processability	177:190	To understand the processability and stability of maltose-containing foods, material characterization of the phase and state transition from its amorphous state is required.
33058153	3	45	dep	crystallization	458:472	arg1	the					454:456	the	454:456	the	454:456	Although the crystallization of amorphous maltose is well understood, few studies have reported the relationship between the crystallization and the glass transition temperature (Tg )-related molecular mobility.
33058153	3	45	dep	crystallization	458:472	arg1	mobility					535:542	-related molecular mobility	516:542	-related molecular mobility	516:542	Although the crystallization of amorphous maltose is well understood, few studies have reported the relationship between the crystallization and the glass transition temperature (Tg )-related molecular mobility.
33058153	4	46	dep	maltose	667:673	arg1	measured					729:736	measured	729:736	are measured at various water activity (aw ) levels	725:775	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	46	dep	maltose	667:673	arg1	RESULTS					788:794	RESULTS	788:794	RESULTS The water-additive principle for maltose	788:835	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	9	47	theme	maltose-containing	1835:1852	arg1	foods					1854:1858	maltose-containing foods	1835:1858	maltose-containing foods	1835:1858	CONCLUSION The S concept exhibits considerable potential for application in controlling the crystallization of amorphous maltose and improving the processability and stability of maltose-containing foods.
33058153	4	48	theme	water-additive	800:813	arg1	principle					815:823	The water-additive principle	796:823	The water-additive principle for maltose	796:835	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	49	theme	time	641:644	arg1	factor					646:651	the corresponding time factor	623:651	the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures	623:850	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	50	theme	-related	596:603	arg1	α-relaxation					605:616	Tg -related α-relaxation	593:616	Tg -related α-relaxation	593:616	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	8	51	theme	molecular	1582:1590	arg1	mobility					1592:1599	molecular mobility	1582:1599	molecular mobility	1582:1599	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility, was based on the William-Landel-Ferry (WLF) equation.
33058153	9	52	dep	processability	1803:1816	arg1	the					1799:1801	the	1799:1801	the	1799:1801	CONCLUSION The S concept exhibits considerable potential for application in controlling the crystallization of amorphous maltose and improving the processability and stability of maltose-containing foods.
33058153	4	53	theme	WPI	839:841	arg1	mixtures					843:850	amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures	657:850	amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures	657:850	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	7	54	theme	water	1396:1400	arg1	plasticization					1402:1415	water plasticization	1396:1415	water plasticization	1396:1415	The α-relaxation temperature of the amorphous samples decreased due to water plasticization, but increased with an increase in the WPI quantity.
33058153	4	55	theme	maltose	679:685	arg1	mixtures					843:850	amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures	657:850	amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures	657:850	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	56	theme	whey	689:692	arg1	mixtures					716:723	whey protein isolate (WPI) mixtures	689:723	whey protein isolate (WPI) mixtures	689:723	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	7	57	theme	samples	1371:1377	arg1	temperature					1342:1352	The α-relaxation temperature	1325:1352	The α-relaxation temperature of the amorphous samples	1325:1377	The α-relaxation temperature of the amorphous samples decreased due to water plasticization, but increased with an increase in the WPI quantity.
33058153	4	58	theme	maltose	667:673	arg1	mixtures					843:850	amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures	657:850	amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures	657:850	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	9	59	theme	S	1671:1671	arg1	concept					1673:1679	The S concept	1667:1679	The S concept	1667:1679	CONCLUSION The S concept exhibits considerable potential for application in controlling the crystallization of amorphous maltose and improving the processability and stability of maltose-containing foods.
33058153	6	60	theme	water	1189:1193	arg1	content					1195:1201	the water content	1185:1201	the water content	1185:1201	The relationship between Tg and the water content was fitted by the Gordon-Taylor model, and its constant showed a compositional dependence for the maltose / WPI mixtures.
33058153	2	61	theme	transition	284:293	arg1	characterization					244:259	material characterization	235:259	material characterization of the phase and state transition from its amorphous state	235:318	To understand the processability and stability of maltose-containing foods, material characterization of the phase and state transition from its amorphous state is required.
33058153	0	62	theme	protein	76:82	arg1	mixtures					92:99	maltose/whey protein isolate mixtures	63:99	maltose/whey protein isolate mixtures	63:99	Crystallization and strength analysis of amorphous maltose and maltose/whey protein isolate mixtures.
33058153	5	63	theme	maltose	1053:1059	arg1	kinetics					1031:1038	The crystal formation and crystallization kinetics	989:1038	The crystal formation and crystallization kinetics of amorphous maltose	989:1059	The crystal formation and crystallization kinetics of amorphous maltose were affected by water and WPI at aw ≥ 0.534 and 25 °C, as determined by X-ray diffraction.
33058153	1	64	theme	starch	151:156	arg1	derivative					137:146	an essential derivative	124:146	an essential derivative of starch	124:156	BACKGROUND Maltose is an essential derivative of starch.
33058153	1	64	theme	starch	151:156	arg1	Maltose					113:119	BACKGROUND Maltose	102:119	BACKGROUND Maltose	102:119	BACKGROUND Maltose is an essential derivative of starch.
33058153	3	65	theme	amorphous	365:373	arg1	maltose					375:381	amorphous maltose	365:381	amorphous maltose	365:381	Although the crystallization of amorphous maltose is well understood, few studies have reported the relationship between the crystallization and the glass transition temperature (Tg )-related molecular mobility.
33058153	4	66	theme	isolate	702:708	arg1	mixtures					716:723	whey protein isolate (WPI) mixtures	689:723	whey protein isolate (WPI) mixtures	689:723	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	0	67	theme	mixtures	92:99	arg1	Crystallization					0:14	Crystallization	0:14	Crystallization	0:14	Crystallization and strength analysis of amorphous maltose and maltose/whey protein isolate mixtures.
33058153	0	67	theme	mixtures	92:99	arg1	analysis					29:36	strength analysis	20:36	strength analysis	20:36	Crystallization and strength analysis of amorphous maltose and maltose/whey protein isolate mixtures.
33058153	8	68	theme	Strength	1474:1481	arg1	value					1487:1491	The Strength (S) value	1470:1491	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility,	1470:1600	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility, was based on the William-Landel-Ferry (WLF) equation.
33058153	4	69	theme	WPI	711:713	arg1	mixtures					716:723	whey protein isolate (WPI) mixtures	689:723	whey protein isolate (WPI) mixtures	689:723	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	70	theme	amorphous	934:942	arg1	maltose					944:950	amorphous maltose	934:950	amorphous maltose	934:950	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	8	71	theme	S	1484:1484	arg1	value					1487:1491	The Strength (S) value	1470:1491	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility,	1470:1600	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility, was based on the William-Landel-Ferry (WLF) equation.
33058153	4	72	theme	aw	765:766	arg1	levels					770:775	various water activity (aw ) levels	741:775	various water activity (aw ) levels	741:775	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	5	73	theme	aw	1095:1096	arg1	≥ 0.534					1098:1104	aw ≥ 0.534	1095:1104	aw ≥ 0.534	1095:1104	The crystal formation and crystallization kinetics of amorphous maltose were affected by water and WPI at aw ≥ 0.534 and 25 °C, as determined by X-ray diffraction.
33058153	9	74	theme	amorphous	1767:1775	arg1	maltose					1777:1783	amorphous maltose	1767:1783	amorphous maltose	1767:1783	CONCLUSION The S concept exhibits considerable potential for application in controlling the crystallization of amorphous maltose and improving the processability and stability of maltose-containing foods.
33058153	8	75	theme	amorphous	1497:1505	arg1	maltose					1507:1513	amorphous maltose	1497:1513	amorphous maltose	1497:1513	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility, was based on the William-Landel-Ferry (WLF) equation.
33058153	8	75	theme	amorphous	1497:1505	arg1	quantitative					1528:1539	quantitative	1528:1539	quantitative	1528:1539	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility, was based on the William-Landel-Ferry (WLF) equation.
33058153	4	76	theme	various	741:747	arg1	levels					770:775	various water activity (aw ) levels	741:775	various water activity (aw ) levels	741:775	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	3	77	theme	few	403:405	arg1	studies					407:413	few studies	403:413	few studies	403:413	Although the crystallization of amorphous maltose is well understood, few studies have reported the relationship between the crystallization and the glass transition temperature (Tg )-related molecular mobility.
33058153	4	78	theme	Tg	593:594	arg1	α-relaxation					605:616	Tg -related α-relaxation	593:616	Tg -related α-relaxation	593:616	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	4	79	theme	activity	755:762	arg1	levels					770:775	various water activity (aw ) levels	741:775	various water activity (aw ) levels	741:775	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	0	80	theme	amorphous	41:49	arg1	maltose					51:57	amorphous maltose	41:57	amorphous maltose	41:57	Crystallization and strength analysis of amorphous maltose and maltose/whey protein isolate mixtures.
33058153	5	81	theme	crystal	993:999	arg1	formation					1001:1009	crystal formation	993:1009	crystal formation	993:1009	The crystal formation and crystallization kinetics of amorphous maltose were affected by water and WPI at aw ≥ 0.534 and 25 °C, as determined by X-ray diffraction.
33058153	3	82	theme	transition	488:497	arg1	Tg					512:513	Tg	512:513	Tg	512:513	Although the crystallization of amorphous maltose is well understood, few studies have reported the relationship between the crystallization and the glass transition temperature (Tg )-related molecular mobility.
33058153	3	82	theme	transition	488:497	arg1	temperature					499:509	the glass transition temperature	478:509	the glass transition temperature (Tg )	478:515	Although the crystallization of amorphous maltose is well understood, few studies have reported the relationship between the crystallization and the glass transition temperature (Tg )-related molecular mobility.
33058153	3	83	theme	molecular	525:533	arg1	mobility					535:542	-related molecular mobility	516:542	-related molecular mobility	516:542	Although the crystallization of amorphous maltose is well understood, few studies have reported the relationship between the crystallization and the glass transition temperature (Tg )-related molecular mobility.
33058153	5	84	theme	X-ray	1134:1138	arg1	diffraction					1140:1150	X-ray diffraction	1134:1150	X-ray diffraction	1134:1150	The crystal formation and crystallization kinetics of amorphous maltose were affected by water and WPI at aw ≥ 0.534 and 25 °C, as determined by X-ray diffraction.
33058153	4	85	theme	corresponding	627:639	arg1	factor					646:651	the corresponding time factor	623:651	the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures	623:850	In this study, water sorption, crystallization, Tg -related α-relaxation, and the corresponding time factor for amorphous maltose and maltose / whey protein isolate (WPI) mixtures are measured at various water activity (aw ) levels and 25 °C. RESULTS The water-additive principle for maltose / WPI mixtures was observed at aw ≤ 0.440 at the molecular level, whereas the crystallization of amorphous maltose occurred at high aw values (≥0.534).
33058153	2	86	theme	maltose-containing	209:226	arg1	foods					228:232	maltose-containing foods	209:232	maltose-containing foods	209:232	To understand the processability and stability of maltose-containing foods, material characterization of the phase and state transition from its amorphous state is required.
33058153	9	87	theme	foods	1854:1858	arg1	stability					1822:1830	stability	1822:1830	stability	1822:1830	CONCLUSION The S concept exhibits considerable potential for application in controlling the crystallization of amorphous maltose and improving the processability and stability of maltose-containing foods.
33058153	9	87	theme	foods	1854:1858	arg1	processability					1803:1816	processability	1803:1816	processability	1803:1816	CONCLUSION The S concept exhibits considerable potential for application in controlling the crystallization of amorphous maltose and improving the processability and stability of maltose-containing foods.
33058153	8	88	theme	compositional	1557:1569	arg1	effects					1571:1577	the compositional effects	1553:1577	the compositional effects on molecular mobility	1553:1599	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility, was based on the William-Landel-Ferry (WLF) equation.
33058153	8	89	theme	William-Landel-Ferry	1619:1638	arg1	equation					1646:1653	the William-Landel-Ferry (WLF) equation	1615:1653	the William-Landel-Ferry (WLF) equation	1615:1653	The Strength (S) value for amorphous maltose, which was a quantitative estimate of the compositional effects on molecular mobility, was based on the William-Landel-Ferry (WLF) equation.
34420708	5	0	theme	bound	691:695	arg1	molecules					703:711	its bound water molecules	687:711	its bound water molecules	687:711	ZnO with its bound water molecules acts as a slight plasticizer in MA, as shown by the lower Tg and the decrease of elastic modulus.
34420708	7	1	theme	wound	1046:1050	arg1	dressings					1052:1060	wound dressings	1046:1060	wound dressings	1046:1060	Finally, MA and HA films show intrinsic antimicrobial properties, enhanced by ZnO, which make them exploitable as wound dressings.
34420708	5	2	from	plasticizer	730:740	arg1	MA					745:746	MA	745:746	MA	745:746	ZnO with its bound water molecules acts as a slight plasticizer in MA, as shown by the lower Tg and the decrease of elastic modulus.
34420708	3	3	theme	physical	415:422	arg1	interactions					424:435	weak physical interactions	410:435	weak physical interactions among mixture components	410:460	MA based samples show weak physical interactions among mixture components, whereas in HA films the extent of these interactions is larger.
34420708	0	4	theme	healing	60:66	arg1	applications					68:79	wound healing applications	54:79	wound healing applications	54:79	Bioactive films based on barley β-glucans and ZnO for wound healing applications.
34420708	7	5	theme	intrinsic	962:970	arg1	properties					986:995	intrinsic antimicrobial properties	962:995	intrinsic antimicrobial properties	962:995	Finally, MA and HA films show intrinsic antimicrobial properties, enhanced by ZnO, which make them exploitable as wound dressings.
34420708	5	6	theme	elastic	794:800	arg1	modulus					802:808	elastic modulus	794:808	elastic modulus	794:808	ZnO with its bound water molecules acts as a slight plasticizer in MA, as shown by the lower Tg and the decrease of elastic modulus.
34420708	1	7	theme	bioactive	259:267	arg1	films					269:273	bioactive films	259:273	bioactive films for wound healing	259:291	In this study, mixtures based on β-glucans and proteins are extracted from barley, in mild (MA) and high (HA) alkaline conditions, and employed with zinc oxide (ZnO) to prepare bioactive films for wound healing.
34420708	7	8	theme	HA	948:949	arg1	films					951:955	MA and HA films	941:955	MA and HA films	941:955	Finally, MA and HA films show intrinsic antimicrobial properties, enhanced by ZnO, which make them exploitable as wound dressings.
34420708	6	9	from	break	913:917	arg1	strength					901:908	strength	901:908	strength at break	901:917	In HA, this effect is evidenced up to ZnO 1%, and above this concentration an increase of strength at break is observed.
34420708	6	9	from	break	913:917	arg1	increase					889:896	an increase	886:896	an increase of strength at break	886:917	In HA, this effect is evidenced up to ZnO 1%, and above this concentration an increase of strength at break is observed.
34420708	1	10	theme	alkaline	192:199	arg1	conditions					201:210	mild (MA) and high (HA) alkaline conditions	168:210	mild (MA) and high (HA) alkaline conditions	168:210	In this study, mixtures based on β-glucans and proteins are extracted from barley, in mild (MA) and high (HA) alkaline conditions, and employed with zinc oxide (ZnO) to prepare bioactive films for wound healing.
34420708	7	11	theme	MA	941:942	arg1	films					951:955	MA and HA films	941:955	MA and HA films	941:955	Finally, MA and HA films show intrinsic antimicrobial properties, enhanced by ZnO, which make them exploitable as wound dressings.
34420708	3	12	theme	MA	388:389	arg1	samples					397:403	MA based samples	388:403	MA based samples	388:403	MA based samples show weak physical interactions among mixture components, whereas in HA films the extent of these interactions is larger.
34420708	3	13	dep	show	405:408	arg1	whereas					463:469	whereas	463:469	whereas	463:469	MA based samples show weak physical interactions among mixture components, whereas in HA films the extent of these interactions is larger.
34420708	2	14	theme	extracts	309:316	arg1	properties					322:331	properties	322:331	properties of resulting films	322:350	Composition of extracts and properties of resulting films depend on pH extraction conditions.
34420708	2	14	theme	extracts	309:316	arg1	Composition					294:304	Composition	294:304	Composition of extracts	294:316	Composition of extracts and properties of resulting films depend on pH extraction conditions.
34420708	1	15	theme	wound	279:283	arg1	healing					285:291	wound healing	279:291	wound healing	279:291	In this study, mixtures based on β-glucans and proteins are extracted from barley, in mild (MA) and high (HA) alkaline conditions, and employed with zinc oxide (ZnO) to prepare bioactive films for wound healing.
34420708	5	16	theme	slight	723:728	arg1	plasticizer					730:740	a slight plasticizer	721:740	a slight plasticizer in MA	721:746	ZnO with its bound water molecules acts as a slight plasticizer in MA, as shown by the lower Tg and the decrease of elastic modulus.
34420708	5	16	theme	slight	723:728	arg1	ZnO					678:680	ZnO	678:680	ZnO with its bound water molecules	678:711	ZnO with its bound water molecules acts as a slight plasticizer in MA, as shown by the lower Tg and the decrease of elastic modulus.
34420708	5	17	theme	lower	765:769	arg1	Tg					771:772	the lower Tg	761:772	the lower Tg	761:772	ZnO with its bound water molecules acts as a slight plasticizer in MA, as shown by the lower Tg and the decrease of elastic modulus.
34420708	2	18	theme	pH	362:363	arg1	conditions					376:385	pH extraction conditions	362:385	pH extraction conditions	362:385	Composition of extracts and properties of resulting films depend on pH extraction conditions.
34420708	5	19	theme	water	697:701	arg1	molecules					703:711	its bound water molecules	687:711	its bound water molecules	687:711	ZnO with its bound water molecules acts as a slight plasticizer in MA, as shown by the lower Tg and the decrease of elastic modulus.
34420708	6	20	from	increase	889:896	arg1	break					913:917	break	913:917	break	913:917	In HA, this effect is evidenced up to ZnO 1%, and above this concentration an increase of strength at break is observed.
34420708	0	21	theme	Bioactive	0:8	arg1	films					10:14	Bioactive films	0:14	Bioactive films	0:14	Bioactive films based on barley β-glucans and ZnO for wound healing applications.
34420708	6	22	theme	ZnO	849:851	arg1	%					854:854	ZnO 1%	849:854	ZnO 1%	849:854	In HA, this effect is evidenced up to ZnO 1%, and above this concentration an increase of strength at break is observed.
34420708	4	23	theme	morphological	654:666	arg1	properties					564:573	their chemico-physical properties	541:573	their chemico-physical properties	541:573	Consequently, their chemico-physical properties are significantly different, as demonstrated by FT-IR, thermal, mechanical and morphological analyses.
34420708	4	23	theme	morphological	654:666	arg1	analyses					668:675	thermal, mechanical and morphological analyses	630:675	thermal, mechanical and morphological analyses	630:675	Consequently, their chemico-physical properties are significantly different, as demonstrated by FT-IR, thermal, mechanical and morphological analyses.
34420708	3	24	theme	HA	474:475	arg1	films					477:481	HA films	474:481	HA films	474:481	MA based samples show weak physical interactions among mixture components, whereas in HA films the extent of these interactions is larger.
34420708	2	25	theme	resulting	336:344	arg1	films					346:350	resulting films	336:350	resulting films	336:350	Composition of extracts and properties of resulting films depend on pH extraction conditions.
34420708	2	26	theme	films	346:350	arg1	properties					322:331	properties	322:331	properties of resulting films	322:350	Composition of extracts and properties of resulting films depend on pH extraction conditions.
34420708	2	26	theme	films	346:350	arg1	Composition					294:304	Composition	294:304	Composition of extracts	294:316	Composition of extracts and properties of resulting films depend on pH extraction conditions.
34420708	1	27	dep	high	182:185	arg1	HA					188:189	HA	188:189	HA	188:189	In this study, mixtures based on β-glucans and proteins are extracted from barley, in mild (MA) and high (HA) alkaline conditions, and employed with zinc oxide (ZnO) to prepare bioactive films for wound healing.
34420708	1	28	theme	mild	168:171	arg1	conditions					201:210	mild (MA) and high (HA) alkaline conditions	168:210	mild (MA) and high (HA) alkaline conditions	168:210	In this study, mixtures based on β-glucans and proteins are extracted from barley, in mild (MA) and high (HA) alkaline conditions, and employed with zinc oxide (ZnO) to prepare bioactive films for wound healing.
34420708	4	29	theme	thermal	630:636	arg1	properties					564:573	their chemico-physical properties	541:573	their chemico-physical properties	541:573	Consequently, their chemico-physical properties are significantly different, as demonstrated by FT-IR, thermal, mechanical and morphological analyses.
34420708	4	29	theme	thermal	630:636	arg1	analyses					668:675	thermal, mechanical and morphological analyses	630:675	thermal, mechanical and morphological analyses	630:675	Consequently, their chemico-physical properties are significantly different, as demonstrated by FT-IR, thermal, mechanical and morphological analyses.
34420708	3	30	theme	interactions	503:514	arg1	larger					519:524	larger	519:524	larger	519:524	MA based samples show weak physical interactions among mixture components, whereas in HA films the extent of these interactions is larger.
34420708	3	30	theme	interactions	503:514	arg1	extent					487:492	the extent	483:492	the extent of these interactions	483:514	MA based samples show weak physical interactions among mixture components, whereas in HA films the extent of these interactions is larger.
34420708	0	31	theme	barley	25:30	arg1	β-glucans					32:40	barley β-glucans	25:40	barley β-glucans	25:40	Bioactive films based on barley β-glucans and ZnO for wound healing applications.
34420708	1	32	theme	zinc	231:234	arg1	oxide					236:240	zinc oxide	231:240	zinc oxide (ZnO)	231:246	In this study, mixtures based on β-glucans and proteins are extracted from barley, in mild (MA) and high (HA) alkaline conditions, and employed with zinc oxide (ZnO) to prepare bioactive films for wound healing.
34420708	1	32	theme	zinc	231:234	arg1	ZnO					243:245	ZnO	243:245	ZnO	243:245	In this study, mixtures based on β-glucans and proteins are extracted from barley, in mild (MA) and high (HA) alkaline conditions, and employed with zinc oxide (ZnO) to prepare bioactive films for wound healing.
34420708	5	33	with	ZnO	678:680	arg1	molecules					703:711	its bound water molecules	687:711	its bound water molecules	687:711	ZnO with its bound water molecules acts as a slight plasticizer in MA, as shown by the lower Tg and the decrease of elastic modulus.
34420708	6	34	theme	strength	901:908	arg1	increase					889:896	an increase	886:896	an increase of strength at break	886:917	In HA, this effect is evidenced up to ZnO 1%, and above this concentration an increase of strength at break is observed.
34420708	7	35	theme	antimicrobial	972:984	arg1	properties					986:995	intrinsic antimicrobial properties	962:995	intrinsic antimicrobial properties	962:995	Finally, MA and HA films show intrinsic antimicrobial properties, enhanced by ZnO, which make them exploitable as wound dressings.
34420708	5	36	theme	modulus	802:808	arg1	Tg					771:772	the lower Tg	761:772	the lower Tg	761:772	ZnO with its bound water molecules acts as a slight plasticizer in MA, as shown by the lower Tg and the decrease of elastic modulus.
34420708	5	36	theme	modulus	802:808	arg1	decrease					782:789	the decrease	778:789	the decrease of elastic modulus	778:808	ZnO with its bound water molecules acts as a slight plasticizer in MA, as shown by the lower Tg and the decrease of elastic modulus.
34420708	2	37	theme	extraction	365:374	arg1	conditions					376:385	pH extraction conditions	362:385	pH extraction conditions	362:385	Composition of extracts and properties of resulting films depend on pH extraction conditions.
34420708	3	38	theme	weak	410:413	arg1	interactions					424:435	weak physical interactions	410:435	weak physical interactions among mixture components	410:460	MA based samples show weak physical interactions among mixture components, whereas in HA films the extent of these interactions is larger.
34420708	3	39	theme	based	391:395	arg1	samples					397:403	MA based samples	388:403	MA based samples	388:403	MA based samples show weak physical interactions among mixture components, whereas in HA films the extent of these interactions is larger.
34420708	4	40	theme	mechanical	639:648	arg1	properties					564:573	their chemico-physical properties	541:573	their chemico-physical properties	541:573	Consequently, their chemico-physical properties are significantly different, as demonstrated by FT-IR, thermal, mechanical and morphological analyses.
34420708	4	40	theme	mechanical	639:648	arg1	analyses					668:675	thermal, mechanical and morphological analyses	630:675	thermal, mechanical and morphological analyses	630:675	Consequently, their chemico-physical properties are significantly different, as demonstrated by FT-IR, thermal, mechanical and morphological analyses.
34420708	0	41	theme	wound	54:58	arg1	healing					60:66	wound healing	54:66	wound healing applications	54:79	Bioactive films based on barley β-glucans and ZnO for wound healing applications.
34420708	4	42	dep	different	593:601	arg1	properties					564:573	their chemico-physical properties	541:573	their chemico-physical properties	541:573	Consequently, their chemico-physical properties are significantly different, as demonstrated by FT-IR, thermal, mechanical and morphological analyses.
34420708	4	42	dep	different	593:601	arg1	analyses					668:675	thermal, mechanical and morphological analyses	630:675	thermal, mechanical and morphological analyses	630:675	Consequently, their chemico-physical properties are significantly different, as demonstrated by FT-IR, thermal, mechanical and morphological analyses.
34420708	4	43	theme	chemico-physical	547:562	arg1	properties					564:573	their chemico-physical properties	541:573	their chemico-physical properties	541:573	Consequently, their chemico-physical properties are significantly different, as demonstrated by FT-IR, thermal, mechanical and morphological analyses.
34420708	4	43	theme	chemico-physical	547:562	arg1	analyses					668:675	thermal, mechanical and morphological analyses	630:675	thermal, mechanical and morphological analyses	630:675	Consequently, their chemico-physical properties are significantly different, as demonstrated by FT-IR, thermal, mechanical and morphological analyses.
34420708	1	44	theme	high	182:185	arg1	conditions					201:210	mild (MA) and high (HA) alkaline conditions	168:210	mild (MA) and high (HA) alkaline conditions	168:210	In this study, mixtures based on β-glucans and proteins are extracted from barley, in mild (MA) and high (HA) alkaline conditions, and employed with zinc oxide (ZnO) to prepare bioactive films for wound healing.
34420708	6	45	dep	%	854:854	arg1	up					843:844	up	843:844	up	843:844	In HA, this effect is evidenced up to ZnO 1%, and above this concentration an increase of strength at break is observed.
34420708	1	46	dep	mild	168:171	arg1	MA					174:175	MA	174:175	MA	174:175	In this study, mixtures based on β-glucans and proteins are extracted from barley, in mild (MA) and high (HA) alkaline conditions, and employed with zinc oxide (ZnO) to prepare bioactive films for wound healing.
34420708	3	47	theme	mixture	443:449	arg1	components					451:460	mixture components	443:460	mixture components	443:460	MA based samples show weak physical interactions among mixture components, whereas in HA films the extent of these interactions is larger.
32282271	4	0	theme	final	1019:1023	arg1	yields					1042:1047	the final oligosaccharides yields	1015:1047	the final oligosaccharides yields	1015:1047	The optimization studies showed that enzyme concentration was the most effective parameter for the final oligosaccharides yields.
32282271	1	1	theme	acceptor	355:362	arg1	molecule					364:371	the acceptor molecule	351:371	the acceptor molecule with different linkages	351:395	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	4	2	theme	optimization	924:935	arg1	studies					937:943	The optimization studies	920:943	The optimization studies	920:943	The optimization studies showed that enzyme concentration was the most effective parameter for the final oligosaccharides yields.
32282271	0	3	theme	response	89:96	arg1	method					145:150	response surface integrated particle swarm optimization method	89:150	response surface integrated particle swarm optimization method	89:150	Determining the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method: an experimental validation study.
32282271	2	4	theme	Method	700:705	arg1	technique					670:678	a hybrid technique	661:678	a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO)	661:749	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	8	5	theme	parameters	1504:1513	arg1	role					1486:1489	the role	1482:1489	the role of different parameters for the production of oligosaccharides in the acceptor reactions of GTFs	1482:1586	These findings will help our understanding in the role of different parameters for the production of oligosaccharides in the acceptor reactions of GTFs.
32282271	0	6	theme	particle	117:124	arg1	method					145:150	response surface integrated particle swarm optimization method	89:150	response surface integrated particle swarm optimization method	89:150	Determining the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method: an experimental validation study.
32282271	3	7	theme	Composite	804:812	arg1	Design					814:819	Central Composite Design	796:819	Central Composite Design	796:819	The experimental design was performed using Central Composite Design and the tested parameters were enzyme concentration, acceptor:donor ratio and the reaction period.
32282271	2	8	theme	Surface	692:698	arg1	RSM					708:710	RSM	708:710	RSM	708:710	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	2	8	theme	Surface	692:698	arg1	Method					700:705	Response Surface Method	683:705	Response Surface Method (RSM)	683:711	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	0	9	theme	integrated	106:115	arg1	method					145:150	response surface integrated particle swarm optimization method	89:150	response surface integrated particle swarm optimization method	89:150	Determining the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method: an experimental validation study.
32282271	1	10	theme	different	378:386	arg1	linkages					388:395	different linkages	378:395	different linkages	378:395	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	2	11	theme	Response	683:690	arg1	RSM					708:710	RSM	708:710	RSM	708:710	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	2	11	theme	Response	683:690	arg1	Method					700:705	Response Surface Method	683:705	Response Surface Method (RSM)	683:711	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	6	12	theme	response	1205:1212	arg1	plots					1222:1226	Even the response surface plots	1196:1226	Even the response surface plots for input parameters	1196:1247	Even the response surface plots for input parameters verified the PSO results, an experimental validation study was performed for the reverification.
32282271	3	13	theme	enzyme	852:857	arg1	parameters					836:845	the tested parameters	825:845	the tested parameters	825:845	The experimental design was performed using Central Composite Design and the tested parameters were enzyme concentration, acceptor:donor ratio and the reaction period.
32282271	3	13	theme	enzyme	852:857	arg1	concentration					859:871	enzyme concentration	852:871	enzyme concentration	852:871	The experimental design was performed using Central Composite Design and the tested parameters were enzyme concentration, acceptor:donor ratio and the reaction period.
32282271	0	14	theme	optimization	132:143	arg1	method					145:150	response surface integrated particle swarm optimization method	89:150	response surface integrated particle swarm optimization method	89:150	Determining the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method: an experimental validation study.
32282271	5	15	theme	donor	1148:1152	arg1	ratio					1154:1158	acceptor:donor ratio	1139:1158	acceptor:donor ratio	1139:1158	The optimal values of the significant parameters determined for enzyme concentration and acceptor:donor ratio were 3.45 U and 0.62, respectively.
32282271	7	16	theme	verification	1363:1374	arg1	consistent					1403:1412	consistent	1403:1412	consistent	1403:1412	The experimental verification results obtained were also consistent with the PSO results.
32282271	7	16	theme	verification	1363:1374	arg1	results					1376:1382	The experimental verification results	1346:1382	The experimental verification results obtained	1346:1391	The experimental verification results obtained were also consistent with the PSO results.
32282271	6	17	theme	surface	1214:1220	arg1	plots					1222:1226	Even the response surface plots	1196:1226	Even the response surface plots for input parameters	1196:1247	Even the response surface plots for input parameters verified the PSO results, an experimental validation study was performed for the reverification.
32282271	0	18	theme	swarm	126:130	arg1	method					145:150	response surface integrated particle swarm optimization method	89:150	response surface integrated particle swarm optimization method	89:150	Determining the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method: an experimental validation study.
32282271	2	19	theme	hybrid	663:668	arg1	technique					670:678	a hybrid technique	661:678	a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO)	661:749	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	0	20	dep	integrated	106:115	arg1	surface					98:104	surface	98:104	surface	98:104	Determining the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method: an experimental validation study.
32282271	4	21	theme	effective	991:999	arg1	parameter					1001:1009	the most effective parameter	982:1009	the most effective parameter for the final oligosaccharides yields	982:1047	The optimization studies showed that enzyme concentration was the most effective parameter for the final oligosaccharides yields.
32282271	4	21	theme	effective	991:999	arg1	concentration					964:976	enzyme concentration	957:976	enzyme concentration	957:976	The optimization studies showed that enzyme concentration was the most effective parameter for the final oligosaccharides yields.
32282271	2	22	theme	reaction	505:512	arg1	parameters					514:523	the optimal reaction parameters	493:523	the optimal reaction parameters for the production of glucansucrase-based oligosaccharides	493:582	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	6	23	theme	validation	1291:1300	arg1	study					1302:1306	an experimental validation study	1275:1306	an experimental validation study	1275:1306	Even the response surface plots for input parameters verified the PSO results, an experimental validation study was performed for the reverification.
32282271	0	24	theme	validation	169:178	arg1	study					180:184	an experimental validation study	153:184	an experimental validation study	153:184	Determining the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method: an experimental validation study.
32282271	8	25	from	reactions	1570:1578	arg1	production					1523:1532	the production	1519:1532	the production of oligosaccharides in the acceptor reactions of GTFs	1519:1586	These findings will help our understanding in the role of different parameters for the production of oligosaccharides in the acceptor reactions of GTFs.
32282271	6	26	theme	experimental	1278:1289	arg1	study					1302:1306	an experimental validation study	1275:1306	an experimental validation study	1275:1306	Even the response surface plots for input parameters verified the PSO results, an experimental validation study was performed for the reverification.
32282271	2	27	theme	acceptor	402:409	arg1	reactions					411:419	The acceptor reactions	398:419	The acceptor reactions	398:419	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	0	28	theme	model	24:28	arg1	parameters					30:39	the optimum model parameters	12:39	the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method	12:150	Determining the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method: an experimental validation study.
32282271	1	29	theme	acceptor	302:309	arg1	sugar					311:315	an acceptor sugar	299:315	an acceptor sugar	299:315	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	8	30	from	oligosaccharides	1537:1552	arg1	reactions					1570:1578	the acceptor reactions	1557:1578	the acceptor reactions of GTFs	1557:1586	These findings will help our understanding in the role of different parameters for the production of oligosaccharides in the acceptor reactions of GTFs.
32282271	2	31	theme	oligosaccharides	567:582	arg1	production					533:542	the production	529:542	the production of glucansucrase-based oligosaccharides	529:582	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	0	32	theme	optimum	16:22	arg1	parameters					30:39	the optimum model parameters	12:39	the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method	12:150	Determining the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method: an experimental validation study.
32282271	1	33	theme	sugar	311:315	arg1	presence					287:294	the presence	283:294	the presence of an acceptor sugar	283:315	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	5	34	theme	enzyme	1114:1119	arg1	concentration					1121:1133	enzyme concentration	1114:1133	enzyme concentration	1114:1133	The optimal values of the significant parameters determined for enzyme concentration and acceptor:donor ratio were 3.45 U and 0.62, respectively.
32282271	8	35	from	production	1523:1532	arg1	reactions					1570:1578	the acceptor reactions	1557:1578	the acceptor reactions of GTFs	1557:1586	These findings will help our understanding in the role of different parameters for the production of oligosaccharides in the acceptor reactions of GTFs.
32282271	2	36	theme	several	440:446	arg1	parameters					448:457	several parameters	440:457	several parameters	440:457	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	2	37	theme	optimal	497:503	arg1	parameters					514:523	the optimal reaction parameters	493:523	the optimal reaction parameters for the production of glucansucrase-based oligosaccharides	493:582	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	0	38	theme	experimental	156:167	arg1	study					180:184	an experimental validation study	153:184	an experimental validation study	153:184	Determining the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method: an experimental validation study.
32282271	8	39	theme	different	1494:1502	arg1	parameters					1504:1513	different parameters	1494:1513	different parameters	1494:1513	These findings will help our understanding in the role of different parameters for the production of oligosaccharides in the acceptor reactions of GTFs.
32282271	5	40	theme	optimal	1054:1060	arg1	values					1062:1067	The optimal values	1050:1067	The optimal values of the significant parameters determined for enzyme concentration and acceptor:donor ratio	1050:1158	The optimal values of the significant parameters determined for enzyme concentration and acceptor:donor ratio were 3.45 U and 0.62, respectively.
32282271	5	40	theme	optimal	1054:1060	arg1	3.45 U					1165:1170	3.45 U	1165:1170	3.45 U	1165:1170	The optimal values of the significant parameters determined for enzyme concentration and acceptor:donor ratio were 3.45 U and 0.62, respectively.
32282271	6	41	theme	input	1232:1236	arg1	parameters					1238:1247	input parameters	1232:1247	input parameters	1232:1247	Even the response surface plots for input parameters verified the PSO results, an experimental validation study was performed for the reverification.
32282271	4	42	theme	oligosaccharides	1025:1040	arg1	yields					1042:1047	the final oligosaccharides yields	1015:1047	the final oligosaccharides yields	1015:1047	The optimization studies showed that enzyme concentration was the most effective parameter for the final oligosaccharides yields.
32282271	2	43	theme	Particle	717:724	arg1	Optimization					732:743	Particle Swarm Optimization	717:743	Particle Swarm Optimization (PSO)	717:749	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	2	43	theme	Particle	717:724	arg1	PSO					746:748	PSO	746:748	PSO	746:748	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	4	44	theme	enzyme	957:962	arg1	parameter					1001:1009	the most effective parameter	982:1009	the most effective parameter for the final oligosaccharides yields	982:1047	The optimization studies showed that enzyme concentration was the most effective parameter for the final oligosaccharides yields.
32282271	4	44	theme	enzyme	957:962	arg1	concentration					964:976	enzyme concentration	957:976	enzyme concentration	957:976	The optimization studies showed that enzyme concentration was the most effective parameter for the final oligosaccharides yields.
32282271	1	45	theme	α-glucans	236:244	arg1	synthesis					223:231	the synthesis	219:231	the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar	219:315	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	0	46	theme	production	61:70	arg1	efficiency					72:81	oligosaccharide production efficiency	45:81	oligosaccharide production efficiency using response surface integrated particle swarm optimization method	45:150	Determining the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method: an experimental validation study.
32282271	1	47	theme	glucosyl	333:340	arg1	units					342:346	glucosyl units	333:346	glucosyl units	333:346	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	5	48	theme	acceptor	1139:1146	arg1	ratio					1154:1158	acceptor:donor ratio	1139:1158	acceptor:donor ratio	1139:1158	The optimal values of the significant parameters determined for enzyme concentration and acceptor:donor ratio were 3.45 U and 0.62, respectively.
32282271	2	49	dep	donor	617:621	arg1	sugars					636:641	sugars	636:641	sugars	636:641	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	2	50	theme	Optimization	732:743	arg1	technique					670:678	a hybrid technique	661:678	a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO)	661:749	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	0	51	theme	oligosaccharide	45:59	arg1	efficiency					72:81	oligosaccharide production efficiency	45:81	oligosaccharide production efficiency using response surface integrated particle swarm optimization method	45:150	Determining the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method: an experimental validation study.
32282271	8	52	theme	GTFs	1583:1586	arg1	reactions					1570:1578	the acceptor reactions	1557:1578	the acceptor reactions of GTFs	1557:1586	These findings will help our understanding in the role of different parameters for the production of oligosaccharides in the acceptor reactions of GTFs.
32282271	1	53	from	oligosaccharides	263:278	arg1	synthesis					223:231	the synthesis	219:231	the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar	219:315	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	1	53	from	oligosaccharides	263:278	arg1	presence					287:294	the presence	283:294	the presence of an acceptor sugar	283:315	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	1	53	from	oligosaccharides	263:278	arg1	α-glucans					236:244	α-glucans	236:244	α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar	236:315	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	5	54	theme	significant	1076:1086	arg1	parameters					1088:1097	the significant parameters	1072:1097	the significant parameters determined for enzyme concentration and acceptor:donor ratio	1072:1158	The optimal values of the significant parameters determined for enzyme concentration and acceptor:donor ratio were 3.45 U and 0.62, respectively.
32282271	6	55	theme	PSO	1262:1264	arg1	results					1266:1272	the PSO results	1258:1272	the PSO results	1258:1272	Even the response surface plots for input parameters verified the PSO results, an experimental validation study was performed for the reverification.
32282271	2	56	theme	Swarm	726:730	arg1	Optimization					732:743	Particle Swarm Optimization	717:743	Particle Swarm Optimization (PSO)	717:749	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	2	56	theme	Swarm	726:730	arg1	PSO					746:748	PSO	746:748	PSO	746:748	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
32282271	8	57	from	understanding	1465:1477	arg1	role					1486:1489	the role	1482:1489	the role of different parameters for the production of oligosaccharides in the acceptor reactions of GTFs	1482:1586	These findings will help our understanding in the role of different parameters for the production of oligosaccharides in the acceptor reactions of GTFs.
32282271	3	58	theme	donor	883:887	arg1	ratio					889:893	acceptor:donor ratio	874:893	acceptor:donor ratio	874:893	The experimental design was performed using Central Composite Design and the tested parameters were enzyme concentration, acceptor:donor ratio and the reaction period.
32282271	3	59	theme	Central	796:802	arg1	Design					814:819	Central Composite Design	796:819	Central Composite Design	796:819	The experimental design was performed using Central Composite Design and the tested parameters were enzyme concentration, acceptor:donor ratio and the reaction period.
32282271	5	60	theme	parameters	1088:1097	arg1	values					1062:1067	The optimal values	1050:1067	The optimal values of the significant parameters determined for enzyme concentration and acceptor:donor ratio	1050:1158	The optimal values of the significant parameters determined for enzyme concentration and acceptor:donor ratio were 3.45 U and 0.62, respectively.
32282271	5	60	theme	parameters	1088:1097	arg1	3.45 U					1165:1170	3.45 U	1165:1170	3.45 U	1165:1170	The optimal values of the significant parameters determined for enzyme concentration and acceptor:donor ratio were 3.45 U and 0.62, respectively.
32282271	1	61	from	synthesis	223:231	arg1	oligosaccharides					263:278	oligosaccharides	263:278	oligosaccharides	263:278	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	1	61	from	synthesis	223:231	arg1	sucrose					251:257	sucrose	251:257	sucrose	251:257	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	3	62	theme	experimental	756:767	arg1	design					769:774	The experimental design	752:774	The experimental design	752:774	The experimental design was performed using Central Composite Design and the tested parameters were enzyme concentration, acceptor:donor ratio and the reaction period.
32282271	3	63	theme	tested	829:834	arg1	parameters					836:845	the tested parameters	825:845	the tested parameters	825:845	The experimental design was performed using Central Composite Design and the tested parameters were enzyme concentration, acceptor:donor ratio and the reaction period.
32282271	3	63	theme	tested	829:834	arg1	concentration					859:871	enzyme concentration	852:871	enzyme concentration	852:871	The experimental design was performed using Central Composite Design and the tested parameters were enzyme concentration, acceptor:donor ratio and the reaction period.
32282271	1	64	from	sucrose	251:257	arg1	synthesis					223:231	the synthesis	219:231	the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar	219:315	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	1	64	from	sucrose	251:257	arg1	presence					287:294	the presence	283:294	the presence of an acceptor sugar	283:315	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	1	64	from	sucrose	251:257	arg1	α-glucans					236:244	α-glucans	236:244	α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar	236:315	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	7	65	theme	PSO	1423:1425	arg1	results					1427:1433	the PSO results	1419:1433	the PSO results	1419:1433	The experimental verification results obtained were also consistent with the PSO results.
32282271	3	66	theme	acceptor	874:881	arg1	ratio					889:893	acceptor:donor ratio	874:893	acceptor:donor ratio	874:893	The experimental design was performed using Central Composite Design and the tested parameters were enzyme concentration, acceptor:donor ratio and the reaction period.
32282271	7	67	with	consistent	1403:1412	arg1	results					1427:1433	the PSO results	1419:1433	the PSO results	1419:1433	The experimental verification results obtained were also consistent with the PSO results.
32282271	8	68	theme	oligosaccharides	1537:1552	arg1	production					1523:1532	the production	1519:1532	the production of oligosaccharides in the acceptor reactions of GTFs	1519:1586	These findings will help our understanding in the role of different parameters for the production of oligosaccharides in the acceptor reactions of GTFs.
32282271	3	69	theme	reaction	903:910	arg1	period					912:917	the reaction period	899:917	the reaction period	899:917	The experimental design was performed using Central Composite Design and the tested parameters were enzyme concentration, acceptor:donor ratio and the reaction period.
32282271	7	70	theme	experimental	1350:1361	arg1	consistent					1403:1412	consistent	1403:1412	consistent	1403:1412	The experimental verification results obtained were also consistent with the PSO results.
32282271	7	70	theme	experimental	1350:1361	arg1	results					1376:1382	The experimental verification results	1346:1382	The experimental verification results obtained	1346:1391	The experimental verification results obtained were also consistent with the PSO results.
32282271	8	71	theme	acceptor	1561:1568	arg1	reactions					1570:1578	the acceptor reactions	1557:1578	the acceptor reactions of GTFs	1557:1586	These findings will help our understanding in the role of different parameters for the production of oligosaccharides in the acceptor reactions of GTFs.
32282271	0	72	dep	Determining	0:10	arg1	study					180:184	an experimental validation study	153:184	an experimental validation study	153:184	Determining the optimum model parameters for oligosaccharide production efficiency using response surface integrated particle swarm optimization method: an experimental validation study.
32282271	1	73	with	molecule	364:371	arg1	linkages					388:395	different linkages	378:395	different linkages	378:395	Glucansucrases (GTFs) catalyzes the synthesis of α-glucans from sucrose and oligosaccharides in the presence of an acceptor sugar by transferring glucosyl units to the acceptor molecule with different linkages.
32282271	2	74	theme	glucansucrase-based	547:565	arg1	oligosaccharides					567:582	glucansucrase-based oligosaccharides	547:582	glucansucrase-based oligosaccharides	547:582	The acceptor reactions can be affected by several parameters and this study aimed to determine the optimal reaction parameters for the production of glucansucrase-based oligosaccharides using sucrose and maltose as the donor and acceptor sugars, respectively via a hybrid technique of Response Surface Method (RSM) and Particle Swarm Optimization (PSO).
33811775	0	0	theme	breast	78:83	arg1	cancer					85:90	breast cancer proliferation and migration	78:118	breast cancer proliferation and migration	78:118	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.
33811775	4	1	theme	Chitosan-alginate	476:492	arg1	scaffolds					499:507	Chitosan-alginate (CA) scaffolds	476:507	Chitosan-alginate (CA) scaffolds	476:507	Chitosan-alginate (CA) scaffolds have been used for 3D culture, but lack integrin binding ligands, resulting in round cell morphology and limited cell-material interaction.
33811775	6	2	theme	polymer	926:932	arg1	concentration					934:946	polymer concentration	926:946	polymer concentration	926:946	All three CA scaffold compositions highly porous with interconnected pores and scaffold stiffness increased with increasing polymer concentration.
33811775	9	3	theme	cell	1268:1271	arg1	migration					1273:1281	The 231 cell migration	1260:1281	The 231 cell migration	1260:1281	The 231 cell migration was evaluated on 2D surfaces after 7 d culture.
33811775	6	4	theme	porous	844:849	arg1	compositions					824:835	All three CA scaffold compositions	802:835	All three CA scaffold compositions highly porous with interconnected pores and scaffold stiffness	802:898	All three CA scaffold compositions highly porous with interconnected pores and scaffold stiffness increased with increasing polymer concentration.
33811775	11	5	theme	CA	1503:1504	arg1	scaffolds					1506:1514	CA scaffolds	1503:1514	CA scaffolds	1503:1514	These results suggest that 231 cells sensed the stiffness of CA scaffolds without the presence of focal adhesions.
33811775	2	6	theme	biophysical	314:324	arg1	signals					326:332	biophysical signals	314:332	biophysical signals	314:332	The extracellular matrix (ECM) stiffens during cancer progression and provides biophysical signals to modulate proliferation, morphology, and metastasis.
33811775	7	7	contain	had	1052:1054	arg1	cultures					1043:1050	All CA scaffold cultures	1027:1050	All CA scaffold cultures	1027:1050	MDA-MB-231 (231) cells were cultured in CA scaffolds and 2D cultures for 7 d. All CA scaffold cultures had similar cell numbers at 7 d and the 231 cells formed clusters that increased in size during the culture.
33811775	7	7	contain	had	1052:1054	arg2	numbers					1069:1075	similar cell numbers	1056:1075	similar cell numbers	1056:1075	MDA-MB-231 (231) cells were cultured in CA scaffolds and 2D cultures for 7 d. All CA scaffold cultures had similar cell numbers at 7 d and the 231 cells formed clusters that increased in size during the culture.
33811775	10	8	theme	%	1409:1409	arg1	CA					1411:1412	4 wt% CA	1405:1412	4 wt% CA	1405:1412	The 6 wt% CA cultured cells had the greatest migration speed, followed by 4 wt% CA, 2D cultures, and 2 wt% CA.
33811775	0	9	from	Evaluation	0:9	arg1	cancer					85:90	breast cancer proliferation and migration	78:118	breast cancer proliferation and migration	78:118	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.
33811775	7	10	theme	CA	1031:1032	arg1	cultures					1043:1050	All CA scaffold cultures	1027:1050	All CA scaffold cultures	1027:1050	MDA-MB-231 (231) cells were cultured in CA scaffolds and 2D cultures for 7 d. All CA scaffold cultures had similar cell numbers at 7 d and the 231 cells formed clusters that increased in size during the culture.
33811775	9	11	theme	2D	1300:1301	arg1	surfaces					1303:1310	2D surfaces	1300:1310	2D surfaces	1300:1310	The 231 cell migration was evaluated on 2D surfaces after 7 d culture.
33811775	1	12	theme	deaths	227:232	arg1	majority					215:222	the majority	211:222	the majority of deaths	211:232	Breast cancer (BCa) is one of the most common cancers for women and metastatic BCa causes the majority of deaths.
33811775	5	13	theme	6 wt	674:677	arg1	%					678:678	6 wt%	674:678	6 wt%	674:678	In this study, 2, 4, and 6 wt% CA scaffolds were produced to mimic the stages of BCa progression and evaluate the BCa response to CA scaffold stiffness.
33811775	6	14	theme	scaffold	815:822	arg1	compositions					824:835	All three CA scaffold compositions	802:835	All three CA scaffold compositions highly porous with interconnected pores and scaffold stiffness	802:898	All three CA scaffold compositions highly porous with interconnected pores and scaffold stiffness increased with increasing polymer concentration.
33811775	7	15	theme	scaffold	1034:1041	arg1	cultures					1043:1050	All CA scaffold cultures	1027:1050	All CA scaffold cultures	1027:1050	MDA-MB-231 (231) cells were cultured in CA scaffolds and 2D cultures for 7 d. All CA scaffold cultures had similar cell numbers at 7 d and the 231 cells formed clusters that increased in size during the culture.
33811775	8	16	theme	d	1216:1216	arg1	culture					1218:1224	the 7 d culture	1210:1224	the 7 d culture	1210:1224	The 2 wt% CA had the largest clusters throughout the 7 d culture compared with the 4 and 6 wt% CA.
33811775	2	17	theme	cancer	282:287	arg1	progression					289:299	cancer progression	282:299	cancer progression	282:299	The extracellular matrix (ECM) stiffens during cancer progression and provides biophysical signals to modulate proliferation, morphology, and metastasis.
33811775	5	18	theme	%	678:678	arg1	scaffolds					683:691	2, 4, and 6 wt% CA scaffolds	664:691	2, 4, and 6 wt% CA scaffolds	664:691	In this study, 2, 4, and 6 wt% CA scaffolds were produced to mimic the stages of BCa progression and evaluate the BCa response to CA scaffold stiffness.
33811775	6	19	theme	CA	812:813	arg1	compositions					824:835	All three CA scaffold compositions	802:835	All three CA scaffold compositions highly porous with interconnected pores and scaffold stiffness	802:898	All three CA scaffold compositions highly porous with interconnected pores and scaffold stiffness increased with increasing polymer concentration.
33811775	5	20	theme	BCa	763:765	arg1	response					767:774	the BCa response	759:774	the BCa response to CA scaffold stiffness	759:799	In this study, 2, 4, and 6 wt% CA scaffolds were produced to mimic the stages of BCa progression and evaluate the BCa response to CA scaffold stiffness.
33811775	2	21	theme	extracellular	239:251	arg1	matrix					253:258	The extracellular matrix	235:258	The extracellular matrix (ECM)	235:264	The extracellular matrix (ECM) stiffens during cancer progression and provides biophysical signals to modulate proliferation, morphology, and metastasis.
33811775	2	21	theme	extracellular	239:251	arg1	ECM					261:263	ECM	261:263	ECM	261:263	The extracellular matrix (ECM) stiffens during cancer progression and provides biophysical signals to modulate proliferation, morphology, and metastasis.
33811775	4	22	theme	cell-material	622:634	arg1	interaction					636:646	limited cell-material interaction	614:646	limited cell-material interaction	614:646	Chitosan-alginate (CA) scaffolds have been used for 3D culture, but lack integrin binding ligands, resulting in round cell morphology and limited cell-material interaction.
33811775	4	23	theme	integrin	549:556	arg1	ligands					566:572	integrin binding ligands	549:572	integrin binding ligands	549:572	Chitosan-alginate (CA) scaffolds have been used for 3D culture, but lack integrin binding ligands, resulting in round cell morphology and limited cell-material interaction.
33811775	4	24	used	used	519:522	arg2	scaffolds					499:507	Chitosan-alginate (CA) scaffolds	476:507	Chitosan-alginate (CA) scaffolds	476:507	Chitosan-alginate (CA) scaffolds have been used for 3D culture, but lack integrin binding ligands, resulting in round cell morphology and limited cell-material interaction.
33811775	0	25	dep	cancer	85:90	arg1	proliferation					92:104	proliferation	92:104	proliferation	92:104	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.
33811775	0	25	dep	cancer	85:90	arg1	migration					110:118	migration	110:118	migration	110:118	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.
33811775	7	26	dep	d.	1024:1025	arg1	had					1052:1054	had	1052:1054	had similar cell numbers at 7 d	1052:1082	MDA-MB-231 (231) cells were cultured in CA scaffolds and 2D cultures for 7 d. All CA scaffold cultures had similar cell numbers at 7 d and the 231 cells formed clusters that increased in size during the culture.
33811775	4	27	theme	limited	614:620	arg1	interaction					636:646	limited cell-material interaction	614:646	limited cell-material interaction	614:646	Chitosan-alginate (CA) scaffolds have been used for 3D culture, but lack integrin binding ligands, resulting in round cell morphology and limited cell-material interaction.
33811775	5	28	theme	BCa	730:732	arg1	progression					734:744	BCa progression	730:744	BCa progression	730:744	In this study, 2, 4, and 6 wt% CA scaffolds were produced to mimic the stages of BCa progression and evaluate the BCa response to CA scaffold stiffness.
33811775	10	29	theme	greatest	1367:1374	arg1	speed					1386:1390	the greatest migration speed	1363:1390	the greatest migration speed	1363:1390	The 6 wt% CA cultured cells had the greatest migration speed, followed by 4 wt% CA, 2D cultures, and 2 wt% CA.
33811775	10	30	theme	2D	1415:1416	arg1	cultures					1418:1425	2D cultures	1415:1425	2D cultures	1415:1425	The 6 wt% CA cultured cells had the greatest migration speed, followed by 4 wt% CA, 2D cultures, and 2 wt% CA.
33811775	9	31	theme	d	1320:1320	arg1	culture					1322:1328	7 d culture	1318:1328	7 d culture	1318:1328	The 231 cell migration was evaluated on 2D surfaces after 7 d culture.
33811775	5	32	theme	progression	734:744	arg1	stages					720:725	the stages	716:725	the stages of BCa progression	716:744	In this study, 2, 4, and 6 wt% CA scaffolds were produced to mimic the stages of BCa progression and evaluate the BCa response to CA scaffold stiffness.
33811775	4	33	theme	3D	528:529	arg1	culture					531:537	3D culture	528:537	3D culture	528:537	Chitosan-alginate (CA) scaffolds have been used for 3D culture, but lack integrin binding ligands, resulting in round cell morphology and limited cell-material interaction.
33811775	11	34	theme	scaffolds	1506:1514	arg1	stiffness					1490:1498	the stiffness	1486:1498	the stiffness of CA scaffolds	1486:1514	These results suggest that 231 cells sensed the stiffness of CA scaffolds without the presence of focal adhesions.
33811775	10	35	theme	migration	1376:1384	arg1	speed					1386:1390	the greatest migration speed	1363:1390	the greatest migration speed	1363:1390	The 6 wt% CA cultured cells had the greatest migration speed, followed by 4 wt% CA, 2D cultures, and 2 wt% CA.
33811775	1	36	theme	common	160:165	arg1	cancers					167:173	the most common cancers	151:173	the most common cancers for women	151:183	Breast cancer (BCa) is one of the most common cancers for women and metastatic BCa causes the majority of deaths.
33811775	0	37	theme	effect	18:23	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.	0:119	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.
33811775	5	38	theme	2	664:664	arg1	scaffolds					683:691	2, 4, and 6 wt% CA scaffolds	664:691	2, 4, and 6 wt% CA scaffolds	664:691	In this study, 2, 4, and 6 wt% CA scaffolds were produced to mimic the stages of BCa progression and evaluate the BCa response to CA scaffold stiffness.
33811775	1	39	theme	cancers	167:173	arg1	cancers					167:173	the most common cancers	151:173	the most common cancers for women	151:183	Breast cancer (BCa) is one of the most common cancers for women and metastatic BCa causes the majority of deaths.
33811775	1	39	theme	cancers	167:173	arg1	one					144:146	one	144:146	one	144:146	Breast cancer (BCa) is one of the most common cancers for women and metastatic BCa causes the majority of deaths.
33811775	7	40	theme	MDA-MB-231	949:958	arg1	cells					966:970	MDA-MB-231 (231) cells	949:970	MDA-MB-231 (231) cells	949:970	MDA-MB-231 (231) cells were cultured in CA scaffolds and 2D cultures for 7 d. All CA scaffold cultures had similar cell numbers at 7 d and the 231 cells formed clusters that increased in size during the culture.
33811775	8	41	theme	2 wt	1165:1168	arg1	CA					1171:1172	The 2 wt% CA	1161:1172	The 2 wt% CA	1161:1172	The 2 wt% CA had the largest clusters throughout the 7 d culture compared with the 4 and 6 wt% CA.
33811775	8	42	dep	CA	1256:1257	arg1	%					1254:1254	%	1254:1254	%	1254:1254	The 2 wt% CA had the largest clusters throughout the 7 d culture compared with the 4 and 6 wt% CA.
33811775	4	43	theme	round	588:592	arg1	morphology					599:608	round cell morphology	588:608	round cell morphology	588:608	Chitosan-alginate (CA) scaffolds have been used for 3D culture, but lack integrin binding ligands, resulting in round cell morphology and limited cell-material interaction.
33811775	0	44	theme	3D	28:29	arg1	stiffness					65:73	3D porous Chitosan-alginate scaffold stiffness	28:73	3D porous Chitosan-alginate scaffold stiffness	28:73	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.
33811775	5	45	theme	4	667:667	arg1	scaffolds					683:691	2, 4, and 6 wt% CA scaffolds	664:691	2, 4, and 6 wt% CA scaffolds	664:691	In this study, 2, 4, and 6 wt% CA scaffolds were produced to mimic the stages of BCa progression and evaluate the BCa response to CA scaffold stiffness.
33811775	10	46	theme	6 wt	1335:1338	arg1	CA					1341:1342	6 wt% CA	1335:1342	The 6 wt% CA cultured cells	1331:1357	The 6 wt% CA cultured cells had the greatest migration speed, followed by 4 wt% CA, 2D cultures, and 2 wt% CA.
33811775	8	47	dep	%	1254:1254	arg1	6 wt					1250:1253	6 wt	1250:1253	6 wt	1250:1253	The 2 wt% CA had the largest clusters throughout the 7 d culture compared with the 4 and 6 wt% CA.
33811775	8	47	dep	%	1254:1254	arg1	4					1244:1244	4	1244:1244	4	1244:1244	The 2 wt% CA had the largest clusters throughout the 7 d culture compared with the 4 and 6 wt% CA.
33811775	7	48	theme	similar	1056:1062	arg1	numbers					1069:1075	similar cell numbers	1056:1075	similar cell numbers	1056:1075	MDA-MB-231 (231) cells were cultured in CA scaffolds and 2D cultures for 7 d. All CA scaffold cultures had similar cell numbers at 7 d and the 231 cells formed clusters that increased in size during the culture.
33811775	5	49	theme	CA	779:780	arg1	stiffness					791:799	CA scaffold stiffness	779:799	CA scaffold stiffness	779:799	In this study, 2, 4, and 6 wt% CA scaffolds were produced to mimic the stages of BCa progression and evaluate the BCa response to CA scaffold stiffness.
33811775	6	50	theme	scaffold	881:888	arg1	stiffness					890:898	scaffold stiffness	881:898	scaffold stiffness	881:898	All three CA scaffold compositions highly porous with interconnected pores and scaffold stiffness increased with increasing polymer concentration.
33811775	10	51	theme	2 wt	1432:1435	arg1	CA					1438:1439	2 wt% CA	1432:1439	2 wt% CA	1432:1439	The 6 wt% CA cultured cells had the greatest migration speed, followed by 4 wt% CA, 2D cultures, and 2 wt% CA.
33811775	8	52	theme	largest	1182:1188	arg1	clusters					1190:1197	the largest clusters	1178:1197	the largest clusters	1178:1197	The 2 wt% CA had the largest clusters throughout the 7 d culture compared with the 4 and 6 wt% CA.
33811775	5	53	theme	CA	680:681	arg1	scaffolds					683:691	2, 4, and 6 wt% CA scaffolds	664:691	2, 4, and 6 wt% CA scaffolds	664:691	In this study, 2, 4, and 6 wt% CA scaffolds were produced to mimic the stages of BCa progression and evaluate the BCa response to CA scaffold stiffness.
33811775	0	54	theme	Chitosan-alginate	38:54	arg1	stiffness					65:73	3D porous Chitosan-alginate scaffold stiffness	28:73	3D porous Chitosan-alginate scaffold stiffness	28:73	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.
33811775	7	55	theme	2D	1006:1007	arg1	cultures					1009:1016	2D cultures	1006:1016	2D cultures	1006:1016	MDA-MB-231 (231) cells were cultured in CA scaffolds and 2D cultures for 7 d. All CA scaffold cultures had similar cell numbers at 7 d and the 231 cells formed clusters that increased in size during the culture.
33811775	10	56	theme	CA	1341:1342	arg1	cells					1353:1357	The 6 wt% CA cultured cells	1331:1357	The 6 wt% CA cultured cells	1331:1357	The 6 wt% CA cultured cells had the greatest migration speed, followed by 4 wt% CA, 2D cultures, and 2 wt% CA.
33811775	10	57	contain	had	1359:1361	arg1	cells					1353:1357	The 6 wt% CA cultured cells	1331:1357	The 6 wt% CA cultured cells	1331:1357	The 6 wt% CA cultured cells had the greatest migration speed, followed by 4 wt% CA, 2D cultures, and 2 wt% CA.
33811775	10	57	contain	had	1359:1361	arg2	speed					1386:1390	the greatest migration speed	1363:1390	the greatest migration speed	1363:1390	The 6 wt% CA cultured cells had the greatest migration speed, followed by 4 wt% CA, 2D cultures, and 2 wt% CA.
33811775	0	58	theme	porous	31:36	arg1	stiffness					65:73	3D porous Chitosan-alginate scaffold stiffness	28:73	3D porous Chitosan-alginate scaffold stiffness	28:73	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.
33811775	7	59	theme	CA	989:990	arg1	scaffolds					992:1000	CA scaffolds	989:1000	CA scaffolds	989:1000	MDA-MB-231 (231) cells were cultured in CA scaffolds and 2D cultures for 7 d. All CA scaffold cultures had similar cell numbers at 7 d and the 231 cells formed clusters that increased in size during the culture.
33811775	4	60	theme	binding	558:564	arg1	ligands					566:572	integrin binding ligands	549:572	integrin binding ligands	549:572	Chitosan-alginate (CA) scaffolds have been used for 3D culture, but lack integrin binding ligands, resulting in round cell morphology and limited cell-material interaction.
33811775	12	61	theme	mechanotransduction	1633:1651	arg1	response					1653:1660	the observed mechanotransduction response	1620:1660	the observed mechanotransduction response	1620:1660	This indicates that a non-integrin-based mechanism may explain the observed mechanotransduction response.
33811775	1	62	theme	Breast	121:126	arg1	cancer					128:133	Breast cancer	121:133	Breast cancer (BCa)	121:139	Breast cancer (BCa) is one of the most common cancers for women and metastatic BCa causes the majority of deaths.
33811775	1	62	theme	Breast	121:126	arg1	BCa					136:138	BCa	136:138	BCa	136:138	Breast cancer (BCa) is one of the most common cancers for women and metastatic BCa causes the majority of deaths.
33811775	10	63	theme	%	1436:1436	arg1	CA					1438:1439	2 wt% CA	1432:1439	2 wt% CA	1432:1439	The 6 wt% CA cultured cells had the greatest migration speed, followed by 4 wt% CA, 2D cultures, and 2 wt% CA.
33811775	6	64	theme	interconnected	856:869	arg1	pores					871:875	interconnected pores	856:875	interconnected pores	856:875	All three CA scaffold compositions highly porous with interconnected pores and scaffold stiffness increased with increasing polymer concentration.
33811775	8	65	contain	had	1174:1176	arg2	clusters					1190:1197	the largest clusters	1178:1197	the largest clusters	1178:1197	The 2 wt% CA had the largest clusters throughout the 7 d culture compared with the 4 and 6 wt% CA.
33811775	8	65	contain	had	1174:1176	arg1	CA					1171:1172	The 2 wt% CA	1161:1172	The 2 wt% CA	1161:1172	The 2 wt% CA had the largest clusters throughout the 7 d culture compared with the 4 and 6 wt% CA.
33811775	7	66	theme	cell	1064:1067	arg1	numbers					1069:1075	similar cell numbers	1056:1075	similar cell numbers	1056:1075	MDA-MB-231 (231) cells were cultured in CA scaffolds and 2D cultures for 7 d. All CA scaffold cultures had similar cell numbers at 7 d and the 231 cells formed clusters that increased in size during the culture.
33811775	12	67	theme	observed	1624:1631	arg1	response					1653:1660	the observed mechanotransduction response	1620:1660	the observed mechanotransduction response	1620:1660	This indicates that a non-integrin-based mechanism may explain the observed mechanotransduction response.
33811775	1	68	theme	metastatic	189:198	arg1	BCa					200:202	metastatic BCa	189:202	metastatic BCa	189:202	Breast cancer (BCa) is one of the most common cancers for women and metastatic BCa causes the majority of deaths.
33811775	10	69	theme	cultured	1344:1351	arg1	cells					1353:1357	The 6 wt% CA cultured cells	1331:1357	The 6 wt% CA cultured cells	1331:1357	The 6 wt% CA cultured cells had the greatest migration speed, followed by 4 wt% CA, 2D cultures, and 2 wt% CA.
33811775	4	70	theme	CA	495:496	arg1	scaffolds					499:507	Chitosan-alginate (CA) scaffolds	476:507	Chitosan-alginate (CA) scaffolds	476:507	Chitosan-alginate (CA) scaffolds have been used for 3D culture, but lack integrin binding ligands, resulting in round cell morphology and limited cell-material interaction.
33811775	12	71	theme	non-integrin-based	1579:1596	arg1	mechanism					1598:1606	a non-integrin-based mechanism	1577:1606	a non-integrin-based mechanism	1577:1606	This indicates that a non-integrin-based mechanism may explain the observed mechanotransduction response.
33811775	3	72	theme	ECM	461:463	arg1	stiffness					465:473	ECM stiffness	461:473	ECM stiffness	461:473	Cells utilize mechanotransduction and integrins to sense and respond to ECM stiffness.
33811775	11	73	theme	adhesions	1546:1554	arg1	presence					1528:1535	the presence	1524:1535	the presence of focal adhesions	1524:1554	These results suggest that 231 cells sensed the stiffness of CA scaffolds without the presence of focal adhesions.
33811775	0	74	theme	stiffness	65:73	arg1	effect					18:23	the effect	14:23	the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration	14:118	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.
33811775	0	75	from	cancer	85:90	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.	0:119	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.
33811775	8	76	theme	%	1169:1169	arg1	CA					1171:1172	The 2 wt% CA	1161:1172	The 2 wt% CA	1161:1172	The 2 wt% CA had the largest clusters throughout the 7 d culture compared with the 4 and 6 wt% CA.
33811775	4	77	theme	cell	594:597	arg1	morphology					599:608	round cell morphology	588:608	round cell morphology	588:608	Chitosan-alginate (CA) scaffolds have been used for 3D culture, but lack integrin binding ligands, resulting in round cell morphology and limited cell-material interaction.
33811775	6	78	with	porous	844:849	arg1	pores					871:875	interconnected pores	856:875	interconnected pores	856:875	All three CA scaffold compositions highly porous with interconnected pores and scaffold stiffness increased with increasing polymer concentration.
33811775	6	78	with	porous	844:849	arg1	stiffness					890:898	scaffold stiffness	881:898	scaffold stiffness	881:898	All three CA scaffold compositions highly porous with interconnected pores and scaffold stiffness increased with increasing polymer concentration.
33811775	5	79	theme	scaffold	782:789	arg1	stiffness					791:799	CA scaffold stiffness	779:799	CA scaffold stiffness	779:799	In this study, 2, 4, and 6 wt% CA scaffolds were produced to mimic the stages of BCa progression and evaluate the BCa response to CA scaffold stiffness.
33811775	10	80	theme	%	1339:1339	arg1	CA					1341:1342	6 wt% CA	1335:1342	The 6 wt% CA cultured cells	1331:1357	The 6 wt% CA cultured cells had the greatest migration speed, followed by 4 wt% CA, 2D cultures, and 2 wt% CA.
33811775	0	81	theme	scaffold	56:63	arg1	stiffness					65:73	3D porous Chitosan-alginate scaffold stiffness	28:73	3D porous Chitosan-alginate scaffold stiffness	28:73	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.
33811775	0	82	from	effect	18:23	arg1	cancer					85:90	breast cancer proliferation and migration	78:118	breast cancer proliferation and migration	78:118	Evaluation of the effect of 3D porous Chitosan-alginate scaffold stiffness on breast cancer proliferation and migration.
33811775	11	83	theme	focal	1540:1544	arg1	adhesions					1546:1554	focal adhesions	1540:1554	focal adhesions	1540:1554	These results suggest that 231 cells sensed the stiffness of CA scaffolds without the presence of focal adhesions.
33811775	10	84	theme	4 wt	1405:1408	arg1	CA					1411:1412	4 wt% CA	1405:1412	4 wt% CA	1405:1412	The 6 wt% CA cultured cells had the greatest migration speed, followed by 4 wt% CA, 2D cultures, and 2 wt% CA.
32014807	1	0	from	period	364:369	arg1	4 °C					385:388	4 °C	385:388	4 °C	385:388	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	2	1	theme	Fourier	440:446	arg1	values					475:480	the color and Fourier Transform Infrared spectra values	426:480	the color and Fourier Transform Infrared spectra values of the films	426:493	The physico-mechanical parameters, the color and Fourier Transform Infrared spectra values of the films were determined.
32014807	2	1	theme	Fourier	440:446	arg1	parameters					414:423	The physico-mechanical parameters	391:423	The physico-mechanical parameters	391:423	The physico-mechanical parameters, the color and Fourier Transform Infrared spectra values of the films were determined.
32014807	1	2	from	4 °C	385:388	arg1	21 days					374:380	21 days	374:380	21 days at 4 °C	374:388	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	1	2	from	4 °C	385:388	arg1	period					364:369	storage period	356:369	storage period of 21 days at 4 °C	356:388	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	7	3	theme	lipid	966:970	arg1	oxidation					972:980	lipid oxidation	966:980	lipid oxidation	966:980	The bacterial counts and lipid oxidation were successfully inhibited using PPE and TEO.
32014807	5	4	theme	treated	714:720	arg1	films					722:726	All treated films	710:726	All treated films	710:726	All treated films showed lower elongation, strength and transparency values compared with chitosan - starch (CH-S) group.
32014807	9	5	theme	shelf	1194:1198	arg1	life					1200:1203	longer shelf life	1187:1203	longer shelf life	1187:1203	Beef samples wrapped with CH-S film containing PPE and TEO also had longer shelf life.
32014807	1	6	theme	current	145:151	arg1	study					153:157	the current study	141:157	the current study	141:157	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	9	7	theme	CH-S	1145:1148	arg1	film					1150:1153	CH-S film	1145:1153	CH-S film containing PPE and TEO	1145:1176	Beef samples wrapped with CH-S film containing PPE and TEO also had longer shelf life.
32014807	9	8	theme	Beef	1119:1122	arg1	samples					1124:1130	Beef samples	1119:1130	Beef samples wrapped with CH-S film containing PPE and TEO	1119:1176	Beef samples wrapped with CH-S film containing PPE and TEO also had longer shelf life.
32014807	8	9	dep	TEO	1067:1069	arg1	%					1065:1065	%	1065:1065	%	1065:1065	CH-S-PPE 1% group containing up to 2% TEO had the best acceptable sensory characteristic.
32014807	8	10	contain	had	1071:1073	arg2	characteristic					1103:1116	the best acceptable sensory characteristic	1075:1116	the best acceptable sensory characteristic	1075:1116	CH-S-PPE 1% group containing up to 2% TEO had the best acceptable sensory characteristic.
32014807	8	10	contain	had	1071:1073	arg1	group					1041:1045	CH-S-PPE 1% group	1029:1045	CH-S-PPE 1% group containing up to 2% TEO	1029:1069	CH-S-PPE 1% group containing up to 2% TEO had the best acceptable sensory characteristic.
32014807	1	11	theme	chitosan-starch	228:242	arg1	film					261:264	pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film	193:264	film	261:264	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	8	12	dep	%	1065:1065	arg1	2					1064:1064	2	1064:1064	2	1064:1064	CH-S-PPE 1% group containing up to 2% TEO had the best acceptable sensory characteristic.
32014807	6	13	theme	-TEO	863:866	arg1	treatment					871:879	CH-S-PPE 1%-TEO 2% treatment	852:879	CH-S-PPE 1%-TEO 2% treatment	852:879	Results showed that CH-S-PPE 1%-TEO 2% treatment had the highest inhibition effect against L. monocytogenes.
32014807	6	14	theme	inhibition	897:906	arg1	effect					908:913	the highest inhibition effect	885:913	the highest inhibition effect	885:913	Results showed that CH-S-PPE 1%-TEO 2% treatment had the highest inhibition effect against L. monocytogenes.
32014807	9	15	contain	containing	1155:1164	arg1	film					1150:1153	CH-S film	1145:1153	CH-S film containing PPE and TEO	1145:1176	Beef samples wrapped with CH-S film containing PPE and TEO also had longer shelf life.
32014807	9	15	contain	containing	1155:1164	arg2	TEO					1174:1176	TEO	1174:1176	TEO	1174:1176	Beef samples wrapped with CH-S film containing PPE and TEO also had longer shelf life.
32014807	9	15	contain	containing	1155:1164	arg2	PPE					1166:1168	PPE	1166:1168	PPE	1166:1168	Beef samples wrapped with CH-S film containing PPE and TEO also had longer shelf life.
32014807	8	16	dep	2	1064:1064	arg1	to					1061:1062	to	1061:1062	to	1061:1062	CH-S-PPE 1% group containing up to 2% TEO had the best acceptable sensory characteristic.
32014807	8	17	theme	sensory	1095:1101	arg1	characteristic					1103:1116	the best acceptable sensory characteristic	1075:1116	the best acceptable sensory characteristic	1075:1116	CH-S-PPE 1% group containing up to 2% TEO had the best acceptable sensory characteristic.
32014807	1	18	theme	study	153:157	arg1	aim					134:136	The aim	130:136	The aim of the current study	130:157	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	0	19	theme	shelf	110:114	arg1	life					116:119	the shelf life	106:119	the shelf life of beef	106:127	Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil can prolong the shelf life of beef.
32014807	0	20	contain	containing	21:30	arg2	kotschyanus					68:78	Thymus kotschyanus	61:78	Thymus kotschyanus	61:78	Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil can prolong the shelf life of beef.
32014807	0	20	contain	containing	21:30	arg2	extract					49:55	pomegranate peel extract	32:55	pomegranate peel extract	32:55	Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil can prolong the shelf life of beef.
32014807	0	20	contain	containing	21:30	arg1	film					16:19	Chitosan-starch film	0:19	Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil	0:92	Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil can prolong the shelf life of beef.
32014807	5	21	theme	strength	753:760	arg1	values					779:784	lower elongation, strength and transparency values	735:784	lower elongation, strength and transparency values	735:784	All treated films showed lower elongation, strength and transparency values compared with chitosan - starch (CH-S) group.
32014807	5	22	theme	starch	811:816	arg1	group					825:829	chitosan - starch (CH-S) group	800:829	chitosan - starch (CH-S) group	800:829	All treated films showed lower elongation, strength and transparency values compared with chitosan - starch (CH-S) group.
32014807	2	23	theme	physico-mechanical	395:412	arg1	values					475:480	the color and Fourier Transform Infrared spectra values	426:480	the color and Fourier Transform Infrared spectra values of the films	426:493	The physico-mechanical parameters, the color and Fourier Transform Infrared spectra values of the films were determined.
32014807	2	23	theme	physico-mechanical	395:412	arg1	parameters					414:423	The physico-mechanical parameters	391:423	The physico-mechanical parameters	391:423	The physico-mechanical parameters, the color and Fourier Transform Infrared spectra values of the films were determined.
32014807	2	24	theme	Infrared	458:465	arg1	spectra					467:473	Infrared spectra	458:473	Infrared spectra	458:473	The physico-mechanical parameters, the color and Fourier Transform Infrared spectra values of the films were determined.
32014807	8	25	theme	CH-S-PPE	1029:1036	arg1	group					1041:1045	CH-S-PPE 1% group	1029:1045	CH-S-PPE 1% group containing up to 2% TEO	1029:1069	CH-S-PPE 1% group containing up to 2% TEO had the best acceptable sensory characteristic.
32014807	4	26	theme	viable	615:620	arg1	counts					622:627	total viable counts	609:627	total viable counts	609:627	total viable counts, lactic acid and Listeria monocytogenes were determined during the storage time.
32014807	0	27	theme	Chitosan-starch	0:14	arg1	film					16:19	Chitosan-starch film	0:19	Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil	0:92	Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil can prolong the shelf life of beef.
32014807	1	28	theme	CH-S	245:248	arg1	film					261:264	pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film	193:264	film	261:264	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	6	29	theme	%	862:862	arg1	treatment					871:879	CH-S-PPE 1%-TEO 2% treatment	852:879	CH-S-PPE 1%-TEO 2% treatment	852:879	Results showed that CH-S-PPE 1%-TEO 2% treatment had the highest inhibition effect against L. monocytogenes.
32014807	4	30	theme	total	609:613	arg1	counts					622:627	total viable counts	609:627	total viable counts	609:627	total viable counts, lactic acid and Listeria monocytogenes were determined during the storage time.
32014807	0	31	theme	pomegranate	32:42	arg1	extract					49:55	pomegranate peel extract	32:55	pomegranate peel extract	32:55	Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil can prolong the shelf life of beef.
32014807	0	32	theme	beef	124:127	arg1	life					116:119	the shelf life	106:119	the shelf life of beef	106:127	Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil can prolong the shelf life of beef.
32014807	4	33	theme	storage	696:702	arg1	time					704:707	the storage time	692:707	the storage time	692:707	total viable counts, lactic acid and Listeria monocytogenes were determined during the storage time.
32014807	9	34	contain	had	1183:1185	arg2	life					1200:1203	longer shelf life	1187:1203	longer shelf life	1187:1203	Beef samples wrapped with CH-S film containing PPE and TEO also had longer shelf life.
32014807	9	34	contain	had	1183:1185	arg1	samples					1124:1130	Beef samples	1119:1130	Beef samples wrapped with CH-S film containing PPE and TEO	1119:1176	Beef samples wrapped with CH-S film containing PPE and TEO also had longer shelf life.
32014807	5	35	theme	transparency	766:777	arg1	values					779:784	lower elongation, strength and transparency values	735:784	lower elongation, strength and transparency values	735:784	All treated films showed lower elongation, strength and transparency values compared with chitosan - starch (CH-S) group.
32014807	1	36	theme	composite	251:259	arg1	film					261:264	pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film	193:264	film	261:264	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	4	37	theme	lactic	630:635	arg1	acid					637:640	lactic acid	630:640	lactic acid	630:640	total viable counts, lactic acid and Listeria monocytogenes were determined during the storage time.
32014807	6	38	theme	CH-S-PPE	852:859	arg1	treatment					871:879	CH-S-PPE 1%-TEO 2% treatment	852:879	CH-S-PPE 1%-TEO 2% treatment	852:879	Results showed that CH-S-PPE 1%-TEO 2% treatment had the highest inhibition effect against L. monocytogenes.
32014807	2	39	theme	color	430:434	arg1	values					475:480	the color and Fourier Transform Infrared spectra values	426:480	the color and Fourier Transform Infrared spectra values of the films	426:493	The physico-mechanical parameters, the color and Fourier Transform Infrared spectra values of the films were determined.
32014807	2	39	theme	color	430:434	arg1	parameters					414:423	The physico-mechanical parameters	391:423	The physico-mechanical parameters	391:423	The physico-mechanical parameters, the color and Fourier Transform Infrared spectra values of the films were determined.
32014807	1	40	theme	film	261:264	arg1	effects					182:188	the effects	178:188	the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C	178:388	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	8	41	theme	1	1038:1038	arg1	%					1039:1039	%	1039:1039	%	1039:1039	CH-S-PPE 1% group containing up to 2% TEO had the best acceptable sensory characteristic.
32014807	1	42	theme	beef	344:347	arg1	shelf-life					330:339	the shelf-life	326:339	the shelf-life of beef during storage period of 21 days at 4 °C	326:388	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	0	43	theme	peel	44:47	arg1	extract					49:55	pomegranate peel extract	32:55	pomegranate peel extract	32:55	Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil can prolong the shelf life of beef.
32014807	6	44	theme	%	869:869	arg1	treatment					871:879	CH-S-PPE 1%-TEO 2% treatment	852:879	CH-S-PPE 1%-TEO 2% treatment	852:879	Results showed that CH-S-PPE 1%-TEO 2% treatment had the highest inhibition effect against L. monocytogenes.
32014807	2	45	theme	films	489:493	arg1	values					475:480	the color and Fourier Transform Infrared spectra values	426:480	the color and Fourier Transform Infrared spectra values of the films	426:493	The physico-mechanical parameters, the color and Fourier Transform Infrared spectra values of the films were determined.
32014807	2	45	theme	films	489:493	arg1	parameters					414:423	The physico-mechanical parameters	391:423	The physico-mechanical parameters	391:423	The physico-mechanical parameters, the color and Fourier Transform Infrared spectra values of the films were determined.
32014807	3	46	theme	oxidation	571:579	arg1	levels					581:586	lipid oxidation levels	565:586	lipid oxidation levels	565:586	Changes in odor, color, pH, thiobarbituric value for lipid oxidation levels and Pseudomonas spp.
32014807	6	47	contain	had	881:883	arg2	effect					908:913	the highest inhibition effect	885:913	the highest inhibition effect	885:913	Results showed that CH-S-PPE 1%-TEO 2% treatment had the highest inhibition effect against L. monocytogenes.
32014807	6	47	contain	had	881:883	arg1	treatment					871:879	CH-S-PPE 1%-TEO 2% treatment	852:879	CH-S-PPE 1%-TEO 2% treatment	852:879	Results showed that CH-S-PPE 1%-TEO 2% treatment had the highest inhibition effect against L. monocytogenes.
32014807	1	48	theme	pomegranate	193:203	arg1	PPE					219:221	pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film	193:264	PPE	219:221	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	0	49	theme	Thymus	61:66	arg1	kotschyanus					68:78	Thymus kotschyanus	61:78	Thymus kotschyanus	61:78	Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil can prolong the shelf life of beef.
32014807	2	50	dep	Fourier	440:446	arg1	Transform					448:456	Transform	448:456	Transform Infrared spectra	448:473	The physico-mechanical parameters, the color and Fourier Transform Infrared spectra values of the films were determined.
32014807	1	51	theme	storage	356:362	arg1	period					364:369	storage period	356:369	storage period of 21 days at 4 °C	356:388	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	0	52	dep	extract	49:55	arg1	oil					90:92	essential oil	80:92	essential oil	80:92	Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil can prolong the shelf life of beef.
32014807	7	53	theme	bacterial	945:953	arg1	counts					955:960	The bacterial counts	941:960	The bacterial counts	941:960	The bacterial counts and lipid oxidation were successfully inhibited using PPE and TEO.
32014807	4	54	theme	Listeria	646:653	arg1	monocytogenes					655:667	Listeria monocytogenes	646:667	Listeria monocytogenes	646:667	total viable counts, lactic acid and Listeria monocytogenes were determined during the storage time.
32014807	5	55	theme	elongation	741:750	arg1	values					779:784	lower elongation, strength and transparency values	735:784	lower elongation, strength and transparency values	735:784	All treated films showed lower elongation, strength and transparency values compared with chitosan - starch (CH-S) group.
32014807	1	56	theme	Thymus	284:289	arg1	TEO					318:320	TEO	318:320	TEO	318:320	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	1	56	theme	Thymus	284:289	arg1	oil					313:315	Thymus kotschyanus essential oil	284:315	Thymus kotschyanus essential oil (TEO)	284:321	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	6	57	theme	1	861:861	arg1	%					862:862	%	862:862	%	862:862	Results showed that CH-S-PPE 1%-TEO 2% treatment had the highest inhibition effect against L. monocytogenes.
32014807	5	58	dep	starch	811:816	arg1	CH-S					819:822	CH-S	819:822	CH-S	819:822	All treated films showed lower elongation, strength and transparency values compared with chitosan - starch (CH-S) group.
32014807	9	59	theme	longer	1187:1192	arg1	life					1200:1203	longer shelf life	1187:1203	longer shelf life	1187:1203	Beef samples wrapped with CH-S film containing PPE and TEO also had longer shelf life.
32014807	3	60	from	Changes	512:518	arg1	pH					536:537	pH	536:537	pH	536:537	Changes in odor, color, pH, thiobarbituric value for lipid oxidation levels and Pseudomonas spp.
32014807	3	60	from	Changes	512:518	arg1	value					555:559	thiobarbituric value	540:559	thiobarbituric value for lipid oxidation levels	540:586	Changes in odor, color, pH, thiobarbituric value for lipid oxidation levels and Pseudomonas spp.
32014807	3	60	from	Changes	512:518	arg1	color					529:533	color	529:533	color	529:533	Changes in odor, color, pH, thiobarbituric value for lipid oxidation levels and Pseudomonas spp.
32014807	3	60	from	Changes	512:518	arg1	odor					523:526	odor	523:526	odor	523:526	Changes in odor, color, pH, thiobarbituric value for lipid oxidation levels and Pseudomonas spp.
32014807	3	60	from	Changes	512:518	arg1	spp					604:606	Pseudomonas spp	592:606	Pseudomonas spp	592:606	Changes in odor, color, pH, thiobarbituric value for lipid oxidation levels and Pseudomonas spp.
32014807	1	61	theme	kotschyanus	291:301	arg1	TEO					318:320	TEO	318:320	TEO	318:320	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	1	61	theme	kotschyanus	291:301	arg1	oil					313:315	Thymus kotschyanus essential oil	284:315	Thymus kotschyanus essential oil (TEO)	284:321	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	1	62	from	effects	182:188	arg1	shelf-life					330:339	the shelf-life	326:339	the shelf-life of beef during storage period of 21 days at 4 °C	326:388	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	8	63	contain	containing	1047:1056	arg2	TEO					1067:1069	up to 2% TEO	1058:1069	up to 2% TEO	1058:1069	CH-S-PPE 1% group containing up to 2% TEO had the best acceptable sensory characteristic.
32014807	8	63	contain	containing	1047:1056	arg1	group					1041:1045	CH-S-PPE 1% group	1029:1045	CH-S-PPE 1% group containing up to 2% TEO	1029:1069	CH-S-PPE 1% group containing up to 2% TEO had the best acceptable sensory characteristic.
32014807	1	64	theme	peel	205:208	arg1	PPE					219:221	pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film	193:264	PPE	219:221	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	8	65	theme	%	1039:1039	arg1	group					1041:1045	CH-S-PPE 1% group	1029:1045	CH-S-PPE 1% group containing up to 2% TEO	1029:1069	CH-S-PPE 1% group containing up to 2% TEO had the best acceptable sensory characteristic.
32014807	1	66	theme	21 days	374:380	arg1	period					364:369	storage period	356:369	storage period of 21 days at 4 °C	356:388	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	3	67	theme	lipid	565:569	arg1	levels					581:586	lipid oxidation levels	565:586	lipid oxidation levels	565:586	Changes in odor, color, pH, thiobarbituric value for lipid oxidation levels and Pseudomonas spp.
32014807	1	68	theme	extract	210:216	arg1	PPE					219:221	pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film	193:264	PPE	219:221	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	0	69	theme	essential	80:88	arg1	oil					90:92	essential oil	80:92	essential oil	80:92	Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil can prolong the shelf life of beef.
32014807	5	70	theme	chitosan	800:807	arg1	group					825:829	chitosan - starch (CH-S) group	800:829	chitosan - starch (CH-S) group	800:829	All treated films showed lower elongation, strength and transparency values compared with chitosan - starch (CH-S) group.
32014807	3	71	theme	thiobarbituric	540:553	arg1	value					555:559	thiobarbituric value	540:559	thiobarbituric value for lipid oxidation levels	540:586	Changes in odor, color, pH, thiobarbituric value for lipid oxidation levels and Pseudomonas spp.
32014807	5	72	theme	lower	735:739	arg1	values					779:784	lower elongation, strength and transparency values	735:784	lower elongation, strength and transparency values	735:784	All treated films showed lower elongation, strength and transparency values compared with chitosan - starch (CH-S) group.
32014807	1	73	theme	essential	303:311	arg1	TEO					318:320	TEO	318:320	TEO	318:320	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	1	73	theme	essential	303:311	arg1	oil					313:315	Thymus kotschyanus essential oil	284:315	Thymus kotschyanus essential oil (TEO)	284:321	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32014807	6	74	theme	highest	889:895	arg1	effect					908:913	the highest inhibition effect	885:913	the highest inhibition effect	885:913	Results showed that CH-S-PPE 1%-TEO 2% treatment had the highest inhibition effect against L. monocytogenes.
32014807	8	75	theme	acceptable	1084:1093	arg1	characteristic					1103:1116	the best acceptable sensory characteristic	1075:1116	the best acceptable sensory characteristic	1075:1116	CH-S-PPE 1% group containing up to 2% TEO had the best acceptable sensory characteristic.
32014807	1	76	theme	PPE	219:221	arg1	effects					182:188	the effects	178:188	the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C	178:388	The aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C.
32735927	6	0	theme	hepatic	1066:1072	arg1	infiltration					1074:1085	the hepatic infiltration	1062:1085	the hepatic infiltration of inflammatory CD4+ and CD8+ T cells	1062:1123	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	0	1	theme	autoimmune	89:98	arg1	hepatitis					100:108	experimental autoimmune hepatitis	76:108	experimental autoimmune hepatitis	76:108	Paeoniae radix alba polysaccharides obtained via optimized extraction treat experimental autoimmune hepatitis effectively.
32735927	3	2	theme	EAH	680:682	arg1	model					689:693	an EAH mice model	677:693	an EAH mice model	677:693	To determine the therapeutic effects of PRAP on experimental autoimmune hepatitis (EAH), we established an EAH mice model.
32735927	6	3	theme	pathway	1238:1244	arg1	inhibition					1204:1213	inhibition	1204:1213	inhibition of the NF-κB signaling pathway	1204:1244	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	2	4	theme	chemical	355:362	arg1	profiles					364:371	The chemical profiles	351:371	The chemical profiles of the obtained PRAP	351:392	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	3	5	theme	mice	684:687	arg1	model					689:693	an EAH mice model	677:693	an EAH mice model	677:693	To determine the therapeutic effects of PRAP on experimental autoimmune hepatitis (EAH), we established an EAH mice model.
32735927	6	6	theme	signaling	1228:1236	arg1	pathway					1238:1244	the NF-κB signaling pathway	1218:1244	the NF-κB signaling pathway	1218:1244	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	7	theme	T	1117:1117	arg1	cells					1119:1123	inflammatory CD4+ and CD8+ T cells	1090:1123	inflammatory CD4+ and CD8+ T cells	1090:1123	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	1	8	theme	2.10 h	270:275	arg1	process					138:144	The extraction process	123:144	The extraction process of Paeoniae radix alba polysaccharides (PRAP)	123:190	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	8	theme	2.10 h	270:275	arg1	ratio					226:230	the liquid-solid ratio	209:230	the liquid-solid ratio of 10.65 mL/g	209:244	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	8	theme	2.10 h	270:275	arg1	time					262:265	the extraction time	247:265	the extraction time of 2.10 h	247:275	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	8	theme	2.10 h	270:275	arg1	repetitions					299:309	the 2 extraction repetitions	282:309	the 2 extraction repetitions through a response surface methodology	282:348	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	5	9	theme	oxidative	920:928	arg1	stress					930:935	oxidative stress	920:935	oxidative stress	920:935	Further study of the mechanism by which PRAP treats EAH showed that PRAP significantly inhibited oxidative stress in the livers of EAH model mice.
32735927	6	10	theme	NF-κB	1222:1226	arg1	pathway					1238:1244	the NF-κB signaling pathway	1218:1244	the NF-κB signaling pathway	1218:1244	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	11	theme	inflammatory	1090:1101	arg1	cells					1119:1123	inflammatory CD4+ and CD8+ T cells	1090:1123	inflammatory CD4+ and CD8+ T cells	1090:1123	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	12	dep	cytokines	1168:1176	arg1	IL-2					1178:1181	IL-2	1178:1181	IL-2	1178:1181	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	12	dep	cytokines	1168:1176	arg1	IL-10					1193:1197	IL-10	1193:1197	IL-10	1193:1197	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	12	dep	cytokines	1168:1176	arg1	cytokines					1168:1176	inflammatory cytokines IL-2, IL-6 and IL-10	1155:1197	inflammatory cytokines IL-2, IL-6 and IL-10	1155:1197	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	12	dep	cytokines	1168:1176	arg1	IL-6					1184:1187	IL-6	1184:1187	IL-6	1184:1187	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	5	13	theme	Further	823:829	arg1	study					831:835	Further study	823:835	Further study of the mechanism by which PRAP treats EAH	823:877	Further study of the mechanism by which PRAP treats EAH showed that PRAP significantly inhibited oxidative stress in the livers of EAH model mice.
32735927	5	14	theme	EAH	954:956	arg1	mice					964:967	EAH model mice	954:967	EAH model mice	954:967	Further study of the mechanism by which PRAP treats EAH showed that PRAP significantly inhibited oxidative stress in the livers of EAH model mice.
32735927	2	15	theme	total	463:467	arg1	phenolics					469:477	total phenolics	463:477	total phenolics	463:477	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	2	15	theme	total	463:467	arg1	contents					430:437	the contents	426:437	the contents of total carbohydrates	426:460	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	0	16	theme	Paeoniae	0:7	arg1	polysaccharides					20:34	Paeoniae radix alba polysaccharides	0:34	Paeoniae radix alba polysaccharides obtained via optimized extraction	0:68	Paeoniae radix alba polysaccharides obtained via optimized extraction treat experimental autoimmune hepatitis effectively.
32735927	5	17	theme	mechanism	844:852	arg1	study					831:835	Further study	823:835	Further study of the mechanism by which PRAP treats EAH	823:877	Further study of the mechanism by which PRAP treats EAH showed that PRAP significantly inhibited oxidative stress in the livers of EAH model mice.
32735927	0	18	theme	radix	9:13	arg1	polysaccharides					20:34	Paeoniae radix alba polysaccharides	0:34	Paeoniae radix alba polysaccharides obtained via optimized extraction	0:68	Paeoniae radix alba polysaccharides obtained via optimized extraction treat experimental autoimmune hepatitis effectively.
32735927	4	19	theme	liver	721:725	arg1	injuries					738:745	liver and spleen injuries	721:745	liver and spleen injuries	721:745	After treated with PRAP, liver and spleen injuries were reduced, and hepatocyte regeneration and liver function were improved.
32735927	2	20	theme	PRAP	389:392	arg1	profiles					364:371	The chemical profiles	351:371	The chemical profiles of the obtained PRAP	351:392	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	2	21	theme	carbohydrates	448:460	arg1	protein					496:502	protein	496:502	protein	496:502	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	2	21	theme	carbohydrates	448:460	arg1	phenolics					469:477	total phenolics	463:477	total phenolics	463:477	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	2	21	theme	carbohydrates	448:460	arg1	acid					487:490	uronic acid	480:490	uronic acid	480:490	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	2	21	theme	carbohydrates	448:460	arg1	contents					430:437	the contents	426:437	the contents of total carbohydrates	426:460	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	6	22	theme	cytokines	1168:1176	arg1	infiltration					1074:1085	the hepatic infiltration	1062:1085	the hepatic infiltration of inflammatory CD4+ and CD8+ T cells	1062:1123	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	22	theme	cytokines	1168:1176	arg1	mice					1046:1049	EAH model mice	1036:1049	EAH model mice	1036:1049	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	22	theme	cytokines	1168:1176	arg1	overexpression					1137:1150	overexpression	1137:1150	EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10	1036:1197	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	2	23	theme	obtained	380:387	arg1	PRAP					389:392	the obtained PRAP	376:392	the obtained PRAP	376:392	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	2	24	theme	total	442:446	arg1	carbohydrates					448:460	total carbohydrates	442:460	total carbohydrates	442:460	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	3	25	theme	PRAP	613:616	arg1	effects					602:608	the therapeutic effects	586:608	the therapeutic effects of PRAP on experimental autoimmune hepatitis (EAH)	586:659	To determine the therapeutic effects of PRAP on experimental autoimmune hepatitis (EAH), we established an EAH mice model.
32735927	2	26	theme	monosaccharide	545:558	arg1	composition					560:570	monosaccharide composition	545:570	monosaccharide composition	545:570	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	4	27	theme	spleen	731:736	arg1	injuries					738:745	liver and spleen injuries	721:745	liver and spleen injuries	721:745	After treated with PRAP, liver and spleen injuries were reduced, and hepatocyte regeneration and liver function were improved.
32735927	6	28	theme	EAH	1036:1038	arg1	infiltration					1074:1085	the hepatic infiltration	1062:1085	the hepatic infiltration of inflammatory CD4+ and CD8+ T cells	1062:1123	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	28	theme	EAH	1036:1038	arg1	mice					1046:1049	EAH model mice	1036:1049	EAH model mice	1036:1049	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	0	29	theme	alba	15:18	arg1	polysaccharides					20:34	Paeoniae radix alba polysaccharides	0:34	Paeoniae radix alba polysaccharides obtained via optimized extraction	0:68	Paeoniae radix alba polysaccharides obtained via optimized extraction treat experimental autoimmune hepatitis effectively.
32735927	1	30	theme	extraction	127:136	arg1	process					138:144	The extraction process	123:144	The extraction process of Paeoniae radix alba polysaccharides (PRAP)	123:190	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	30	theme	extraction	127:136	arg1	ratio					226:230	the liquid-solid ratio	209:230	the liquid-solid ratio of 10.65 mL/g	209:244	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	30	theme	extraction	127:136	arg1	repetitions					299:309	the 2 extraction repetitions	282:309	the 2 extraction repetitions through a response surface methodology	282:348	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	30	theme	extraction	127:136	arg1	time					262:265	the extraction time	247:265	the extraction time of 2.10 h	247:275	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	3	31	from	effects	602:608	arg1	EAH					656:658	EAH	656:658	EAH	656:658	To determine the therapeutic effects of PRAP on experimental autoimmune hepatitis (EAH), we established an EAH mice model.
32735927	3	31	from	effects	602:608	arg1	hepatitis					645:653	experimental autoimmune hepatitis	621:653	experimental autoimmune hepatitis (EAH)	621:659	To determine the therapeutic effects of PRAP on experimental autoimmune hepatitis (EAH), we established an EAH mice model.
32735927	1	32	theme	liquid-solid	213:224	arg1	process					138:144	The extraction process	123:144	The extraction process of Paeoniae radix alba polysaccharides (PRAP)	123:190	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	32	theme	liquid-solid	213:224	arg1	ratio					226:230	the liquid-solid ratio	209:230	the liquid-solid ratio of 10.65 mL/g	209:244	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	2	33	theme	uronic	480:485	arg1	acid					487:490	uronic acid	480:490	uronic acid	480:490	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	2	33	theme	uronic	480:485	arg1	contents					430:437	the contents	426:437	the contents of total carbohydrates	426:460	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	1	34	theme	extraction	288:297	arg1	process					138:144	The extraction process	123:144	The extraction process of Paeoniae radix alba polysaccharides (PRAP)	123:190	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	34	theme	extraction	288:297	arg1	repetitions					299:309	the 2 extraction repetitions	282:309	the 2 extraction repetitions through a response surface methodology	282:348	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	6	35	theme	model	1040:1044	arg1	infiltration					1074:1085	the hepatic infiltration	1062:1085	the hepatic infiltration of inflammatory CD4+ and CD8+ T cells	1062:1123	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	35	theme	model	1040:1044	arg1	mice					1046:1049	EAH model mice	1036:1049	EAH model mice	1036:1049	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	36	theme	immune	1003:1008	arg1	reactions					1023:1031	immune inflammatory reactions	1003:1031	immune inflammatory reactions	1003:1031	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	2	37	theme	FT-IR	526:530	arg1	spectrum					532:539	the FT-IR spectrum	522:539	the FT-IR spectrum	522:539	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	4	38	theme	liver	793:797	arg1	function					799:806	liver function	793:806	liver function	793:806	After treated with PRAP, liver and spleen injuries were reduced, and hepatocyte regeneration and liver function were improved.
32735927	6	39	theme	inflammatory	1010:1021	arg1	reactions					1023:1031	immune inflammatory reactions	1003:1031	immune inflammatory reactions	1003:1031	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	40	theme	CD8+	1112:1115	arg1	cells					1119:1123	inflammatory CD4+ and CD8+ T cells	1090:1123	inflammatory CD4+ and CD8+ T cells	1090:1123	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	0	41	theme	optimized	49:57	arg1	extraction					59:68	optimized extraction	49:68	optimized extraction	49:68	Paeoniae radix alba polysaccharides obtained via optimized extraction treat experimental autoimmune hepatitis effectively.
32735927	3	42	theme	therapeutic	590:600	arg1	effects					602:608	the therapeutic effects	586:608	the therapeutic effects of PRAP on experimental autoimmune hepatitis (EAH)	586:659	To determine the therapeutic effects of PRAP on experimental autoimmune hepatitis (EAH), we established an EAH mice model.
32735927	1	43	theme	response	321:328	arg1	methodology					338:348	a response surface methodology	319:348	a response surface methodology	319:348	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	4	44	theme	hepatocyte	765:774	arg1	regeneration					776:787	hepatocyte regeneration	765:787	hepatocyte regeneration	765:787	After treated with PRAP, liver and spleen injuries were reduced, and hepatocyte regeneration and liver function were improved.
32735927	3	45	theme	experimental	621:632	arg1	EAH					656:658	EAH	656:658	EAH	656:658	To determine the therapeutic effects of PRAP on experimental autoimmune hepatitis (EAH), we established an EAH mice model.
32735927	3	45	theme	experimental	621:632	arg1	hepatitis					645:653	experimental autoimmune hepatitis	621:653	experimental autoimmune hepatitis (EAH)	621:659	To determine the therapeutic effects of PRAP on experimental autoimmune hepatitis (EAH), we established an EAH mice model.
32735927	1	46	theme	Paeoniae	149:156	arg1	polysaccharides					169:183	Paeoniae radix alba polysaccharides	149:183	Paeoniae radix alba polysaccharides (PRAP)	149:190	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	46	theme	Paeoniae	149:156	arg1	PRAP					186:189	PRAP	186:189	PRAP	186:189	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	6	47	theme	cells	1119:1123	arg1	infiltration					1074:1085	the hepatic infiltration	1062:1085	the hepatic infiltration of inflammatory CD4+ and CD8+ T cells	1062:1123	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	1	48	theme	10.65 mL/g	235:244	arg1	process					138:144	The extraction process	123:144	The extraction process of Paeoniae radix alba polysaccharides (PRAP)	123:190	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	48	theme	10.65 mL/g	235:244	arg1	ratio					226:230	the liquid-solid ratio	209:230	the liquid-solid ratio of 10.65 mL/g	209:244	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	48	theme	10.65 mL/g	235:244	arg1	time					262:265	the extraction time	247:265	the extraction time of 2.10 h	247:275	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	48	theme	10.65 mL/g	235:244	arg1	repetitions					299:309	the 2 extraction repetitions	282:309	the 2 extraction repetitions through a response surface methodology	282:348	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	5	49	theme	model	958:962	arg1	mice					964:967	EAH model mice	954:967	EAH model mice	954:967	Further study of the mechanism by which PRAP treats EAH showed that PRAP significantly inhibited oxidative stress in the livers of EAH model mice.
32735927	3	50	theme	autoimmune	634:643	arg1	EAH					656:658	EAH	656:658	EAH	656:658	To determine the therapeutic effects of PRAP on experimental autoimmune hepatitis (EAH), we established an EAH mice model.
32735927	3	50	theme	autoimmune	634:643	arg1	hepatitis					645:653	experimental autoimmune hepatitis	621:653	experimental autoimmune hepatitis (EAH)	621:659	To determine the therapeutic effects of PRAP on experimental autoimmune hepatitis (EAH), we established an EAH mice model.
32735927	1	51	theme	radix	158:162	arg1	polysaccharides					169:183	Paeoniae radix alba polysaccharides	149:183	Paeoniae radix alba polysaccharides (PRAP)	149:190	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	51	theme	radix	158:162	arg1	PRAP					186:189	PRAP	186:189	PRAP	186:189	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	6	52	theme	CD4+	1103:1106	arg1	cells					1119:1123	inflammatory CD4+ and CD8+ T cells	1090:1123	inflammatory CD4+ and CD8+ T cells	1090:1123	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	0	53	theme	experimental	76:87	arg1	hepatitis					100:108	experimental autoimmune hepatitis	76:108	experimental autoimmune hepatitis	76:108	Paeoniae radix alba polysaccharides obtained via optimized extraction treat experimental autoimmune hepatitis effectively.
32735927	2	54	dep	characterized	399:411	arg1	measuring					416:424	measuring	416:424	measuring the contents of total carbohydrates, total phenolics, uronic acid and protein	416:502	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	2	54	dep	characterized	399:411	arg1	analyzing					512:520	analyzing	512:520	analyzing the FT-IR spectrum and monosaccharide composition	512:570	The chemical profiles of the obtained PRAP were characterized by measuring the contents of total carbohydrates, total phenolics, uronic acid and protein, and by analyzing the FT-IR spectrum and monosaccharide composition.
32735927	1	55	theme	alba	164:167	arg1	polysaccharides					169:183	Paeoniae radix alba polysaccharides	149:183	Paeoniae radix alba polysaccharides (PRAP)	149:190	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	55	theme	alba	164:167	arg1	PRAP					186:189	PRAP	186:189	PRAP	186:189	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	5	56	theme	mice	964:967	arg1	livers					944:949	the livers	940:949	the livers of EAH model mice	940:967	Further study of the mechanism by which PRAP treats EAH showed that PRAP significantly inhibited oxidative stress in the livers of EAH model mice.
32735927	1	57	theme	surface	330:336	arg1	methodology					338:348	a response surface methodology	319:348	a response surface methodology	319:348	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	6	58	theme	inflammatory	1155:1166	arg1	IL-2					1178:1181	IL-2	1178:1181	IL-2	1178:1181	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	58	theme	inflammatory	1155:1166	arg1	IL-10					1193:1197	IL-10	1193:1197	IL-10	1193:1197	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	58	theme	inflammatory	1155:1166	arg1	cytokines					1168:1176	inflammatory cytokines IL-2, IL-6 and IL-10	1155:1197	inflammatory cytokines IL-2, IL-6 and IL-10	1155:1197	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	6	58	theme	inflammatory	1155:1166	arg1	IL-6					1184:1187	IL-6	1184:1187	IL-6	1184:1187	More importantly, PRAP inhibited immune inflammatory reactions in EAH model mice, including the hepatic infiltration of inflammatory CD4+ and CD8+ T cells, as well as overexpression of inflammatory cytokines IL-2, IL-6 and IL-10, via inhibition of the NF-κB signaling pathway.
32735927	1	59	theme	polysaccharides	169:183	arg1	process					138:144	The extraction process	123:144	The extraction process of Paeoniae radix alba polysaccharides (PRAP)	123:190	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	59	theme	polysaccharides	169:183	arg1	ratio					226:230	the liquid-solid ratio	209:230	the liquid-solid ratio of 10.65 mL/g	209:244	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	59	theme	polysaccharides	169:183	arg1	repetitions					299:309	the 2 extraction repetitions	282:309	the 2 extraction repetitions through a response surface methodology	282:348	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	59	theme	polysaccharides	169:183	arg1	time					262:265	the extraction time	247:265	the extraction time of 2.10 h	247:275	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	60	theme	extraction	251:260	arg1	process					138:144	The extraction process	123:144	The extraction process of Paeoniae radix alba polysaccharides (PRAP)	123:190	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
32735927	1	60	theme	extraction	251:260	arg1	time					262:265	the extraction time	247:265	the extraction time of 2.10 h	247:275	The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology.
34694728	0	0	theme	oil/water	118:126	arg1	separation					128:137	oil/water separation	118:137	oil/water separation	118:137	Directional, super-hydrophobic cellulose nanofiber/polyvinyl alcohol/montmorillonite aerogels as green absorbents for oil/water separation.
34694728	2	1	with	freezing	399:406	arg1	CNF					434:436	CNF	434:436	CNF	434:436	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	2	1	with	freezing	399:406	arg1	nanofibre					423:431	cellulose nanofibre	413:431	cellulose nanofibre (CNF) as the base material	413:458	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	1	2	theme	organic	179:185	arg1	pollution					195:203	organic solvent pollution	179:203	organic solvent pollution	179:203	Nowadays, the problem of oil spill and organic solvent pollution has become more and more serious, and developing a green and efficient treatment method has become a research hotspot.
34694728	4	3	theme	weight	1015:1020	arg1	times					994:998	40-68 times	988:998	40-68 times of its initial weight	988:1020	Notably, the composite aerogel has a good adsorption effect on different oils and organic solutions, and its adsorption capacity can reach 40-68 times of its initial weight.
34694728	3	4	theme	contact	825:831	arg1	angle					833:837	water contact angle	819:837	water contact angle of 140°	819:845	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	3	5	theme	three-dimensional	686:702	arg1	structure					730:738	three-dimensional inter-perforation network structure	686:738	three-dimensional inter-perforation network structure	686:738	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	2	6	theme	hydrophobic	578:588	arg1	treatment					590:598	hydrophobic treatment	578:598	hydrophobic treatment with chemical vapour deposition	578:630	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	1	7	theme	solvent	187:193	arg1	pollution					195:203	organic solvent pollution	179:203	organic solvent pollution	179:203	Nowadays, the problem of oil spill and organic solvent pollution has become more and more serious, and developing a green and efficient treatment method has become a research hotspot.
34694728	1	8	theme	efficient	266:274	arg1	method					286:291	a green and efficient treatment method	254:291	a green and efficient treatment method	254:291	Nowadays, the problem of oil spill and organic solvent pollution has become more and more serious, and developing a green and efficient treatment method has become a research hotspot.
34694728	6	9	dep	times	1230:1234	arg1	weight					1240:1245	its weight	1236:1245	1290 times its weight without deformation after 2 weeks	1225:1279	More importantly, the composite aerogel had high strength, whose compressive stress at 70 % strain reached 0.15 MPa and could bear over 1290 times its weight without deformation after 2 weeks.
34694728	3	10	theme	inter-perforation	704:720	arg1	structure					730:738	three-dimensional inter-perforation network structure	686:738	three-dimensional inter-perforation network structure	686:738	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	4	11	theme	composite	862:870	arg1	aerogel					872:878	the composite aerogel	858:878	the composite aerogel	858:878	Notably, the composite aerogel has a good adsorption effect on different oils and organic solutions, and its adsorption capacity can reach 40-68 times of its initial weight.
34694728	7	12	theme	solvents	1366:1373	arg1	adsorption					1335:1344	the adsorption	1331:1344	the adsorption of oils and organic solvents	1331:1373	A new, green, simple and efficient absorbent for the adsorption of oils and organic solvents is provided.
34694728	1	13	theme	treatment	276:284	arg1	method					286:291	a green and efficient treatment method	254:291	a green and efficient treatment method	254:291	Nowadays, the problem of oil spill and organic solvent pollution has become more and more serious, and developing a green and efficient treatment method has become a research hotspot.
34694728	6	14	contain	had	1129:1131	arg1	aerogel					1121:1127	the composite aerogel	1107:1127	the composite aerogel	1107:1127	More importantly, the composite aerogel had high strength, whose compressive stress at 70 % strain reached 0.15 MPa and could bear over 1290 times its weight without deformation after 2 weeks.
34694728	6	14	contain	had	1129:1131	arg2	strength					1138:1145	high strength	1133:1145	high strength	1133:1145	More importantly, the composite aerogel had high strength, whose compressive stress at 70 % strain reached 0.15 MPa and could bear over 1290 times its weight without deformation after 2 weeks.
34694728	2	15	theme	aerogel	376:382	arg1	preparation					336:346	the preparation	332:346	the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition	332:630	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	3	16	theme	water	819:823	arg1	angle					833:837	water contact angle	819:837	water contact angle of 140°	819:845	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	1	17	theme	pollution	195:203	arg1	Nowadays					140:147	Nowadays	140:147	Nowadays	140:147	Nowadays, the problem of oil spill and organic solvent pollution has become more and more serious, and developing a green and efficient treatment method has become a research hotspot.
34694728	1	17	theme	pollution	195:203	arg1	problem					154:160	the problem	150:160	the problem of oil spill and organic solvent pollution	150:203	Nowadays, the problem of oil spill and organic solvent pollution has become more and more serious, and developing a green and efficient treatment method has become a research hotspot.
34694728	4	18	theme	organic	931:937	arg1	solutions					939:947	organic solutions	931:947	organic solutions	931:947	Notably, the composite aerogel has a good adsorption effect on different oils and organic solutions, and its adsorption capacity can reach 40-68 times of its initial weight.
34694728	2	19	theme	vapour	614:619	arg1	deposition					621:630	chemical vapour deposition	605:630	chemical vapour deposition	605:630	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	6	20	theme	high	1133:1136	arg1	strength					1138:1145	high strength	1133:1145	high strength	1133:1145	More importantly, the composite aerogel had high strength, whose compressive stress at 70 % strain reached 0.15 MPa and could bear over 1290 times its weight without deformation after 2 weeks.
34694728	2	21	with	treatment	590:598	arg1	deposition					621:630	chemical vapour deposition	605:630	chemical vapour deposition	605:630	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	2	22	theme	cellulose	413:421	arg1	CNF					434:436	CNF	434:436	CNF	434:436	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	2	22	theme	cellulose	413:421	arg1	nanofibre					423:431	cellulose nanofibre	413:431	cellulose nanofibre (CNF) as the base material	413:458	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	3	23	theme	low	741:743	arg1	26.52 mg⋅cm-3					754:766	26.52 mg⋅cm-3	754:766	26.52 mg⋅cm-3	754:766	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	3	23	theme	low	741:743	arg1	density					745:751	low density	741:751	low density (26.52 mg⋅cm-3 )	741:768	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	2	24	theme	chemical	605:612	arg1	deposition					621:630	chemical vapour deposition	605:630	chemical vapour deposition	605:630	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	4	25	contain	has	880:882	arg1	aerogel					872:878	the composite aerogel	858:878	the composite aerogel	858:878	Notably, the composite aerogel has a good adsorption effect on different oils and organic solutions, and its adsorption capacity can reach 40-68 times of its initial weight.
34694728	4	25	contain	has	880:882	arg2	effect					902:907	a good adsorption effect	884:907	a good adsorption effect on different oils and organic solutions	884:947	Notably, the composite aerogel has a good adsorption effect on different oils and organic solutions, and its adsorption capacity can reach 40-68 times of its initial weight.
34694728	0	26	theme	Directional	0:10	arg1	alcohol/montmorillonite					61:83	Directional, super-hydrophobic cellulose nanofiber/polyvinyl alcohol/montmorillonite	0:83	Directional, super-hydrophobic cellulose nanofiber/polyvinyl alcohol/montmorillonite	0:83	Directional, super-hydrophobic cellulose nanofiber/polyvinyl alcohol/montmorillonite aerogels as green absorbents for oil/water separation.
34694728	5	27	theme	complete	1029:1036	arg1	adsorption					1038:1047	complete adsorption	1029:1047	complete adsorption	1029:1047	After complete adsorption, the aerogel could be easily collected.
34694728	7	28	theme	oils	1349:1352	arg1	adsorption					1335:1344	the adsorption	1331:1344	the adsorption of oils and organic solvents	1331:1373	A new, green, simple and efficient absorbent for the adsorption of oils and organic solvents is provided.
34694728	0	29	theme	cellulose	31:39	arg1	alcohol/montmorillonite					61:83	Directional, super-hydrophobic cellulose nanofiber/polyvinyl alcohol/montmorillonite	0:83	Directional, super-hydrophobic cellulose nanofiber/polyvinyl alcohol/montmorillonite	0:83	Directional, super-hydrophobic cellulose nanofiber/polyvinyl alcohol/montmorillonite aerogels as green absorbents for oil/water separation.
34694728	3	30	theme	high	771:774	arg1	porosity					776:783	high porosity	771:783	high porosity (96.1 %)	771:792	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	3	30	theme	high	771:774	arg1	%					791:791	96.1 %	786:791	96.1 %	786:791	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	7	31	theme	green	1289:1293	arg1	absorbent					1317:1325	A new, green, simple and efficient absorbent	1282:1325	A new, green, simple and efficient absorbent for the adsorption of oils and organic solvents	1282:1373	A new, green, simple and efficient absorbent for the adsorption of oils and organic solvents is provided.
34694728	6	32	theme	composite	1111:1119	arg1	aerogel					1121:1127	the composite aerogel	1107:1127	the composite aerogel	1107:1127	More importantly, the composite aerogel had high strength, whose compressive stress at 70 % strain reached 0.15 MPa and could bear over 1290 times its weight without deformation after 2 weeks.
34694728	4	33	theme	adsorption	958:967	arg1	capacity					969:976	its adsorption capacity	954:976	its adsorption capacity	954:976	Notably, the composite aerogel has a good adsorption effect on different oils and organic solutions, and its adsorption capacity can reach 40-68 times of its initial weight.
34694728	4	34	theme	adsorption	891:900	arg1	effect					902:907	a good adsorption effect	884:907	a good adsorption effect on different oils and organic solutions	884:947	Notably, the composite aerogel has a good adsorption effect on different oils and organic solutions, and its adsorption capacity can reach 40-68 times of its initial weight.
34694728	2	35	theme	super-hydrophobic	358:374	arg1	aerogel					376:382	porous super-hydrophobic aerogel	351:382	porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material	351:458	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	2	35	theme	super-hydrophobic	358:374	arg1	montmorillonite					516:530	montmorillonite	516:530	montmorillonite (MMT)	516:536	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	2	35	theme	super-hydrophobic	358:374	arg1	alcohol					471:477	polyvinyl alcohol	461:477	polyvinyl alcohol (PVA) as the cross-linking agent	461:510	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	2	36	theme	directional	387:397	arg1	freezing					399:406	directional freezing	387:406	directional freezing with cellulose nanofibre (CNF) as the base material	387:458	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	1	37	theme	research	306:313	arg1	hotspot					315:321	a research hotspot	304:321	a research hotspot	304:321	Nowadays, the problem of oil spill and organic solvent pollution has become more and more serious, and developing a green and efficient treatment method has become a research hotspot.
34694728	4	38	theme	different	912:920	arg1	oils					922:925	different oils	912:925	different oils	912:925	Notably, the composite aerogel has a good adsorption effect on different oils and organic solutions, and its adsorption capacity can reach 40-68 times of its initial weight.
34694728	1	39	dep	become	209:214	arg1	become					297:302	become	297:302	has become a research hotspot	293:321	Nowadays, the problem of oil spill and organic solvent pollution has become more and more serious, and developing a green and efficient treatment method has become a research hotspot.
34694728	4	40	theme	initial	1007:1013	arg1	weight					1015:1020	its initial weight	1003:1020	its initial weight	1003:1020	Notably, the composite aerogel has a good adsorption effect on different oils and organic solutions, and its adsorption capacity can reach 40-68 times of its initial weight.
34694728	0	41	theme	nanofiber/polyvinyl	41:59	arg1	alcohol/montmorillonite					61:83	Directional, super-hydrophobic cellulose nanofiber/polyvinyl alcohol/montmorillonite	0:83	Directional, super-hydrophobic cellulose nanofiber/polyvinyl alcohol/montmorillonite	0:83	Directional, super-hydrophobic cellulose nanofiber/polyvinyl alcohol/montmorillonite aerogels as green absorbents for oil/water separation.
34694728	4	42	from	effect	902:907	arg1	oils					922:925	different oils	912:925	different oils	912:925	Notably, the composite aerogel has a good adsorption effect on different oils and organic solutions, and its adsorption capacity can reach 40-68 times of its initial weight.
34694728	4	42	from	effect	902:907	arg1	solutions					939:947	organic solutions	931:947	organic solutions	931:947	Notably, the composite aerogel has a good adsorption effect on different oils and organic solutions, and its adsorption capacity can reach 40-68 times of its initial weight.
34694728	2	43	theme	base	446:449	arg1	material					451:458	the base material	442:458	the base material	442:458	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	7	44	theme	efficient	1307:1315	arg1	absorbent					1317:1325	A new, green, simple and efficient absorbent	1282:1325	A new, green, simple and efficient absorbent for the adsorption of oils and organic solvents	1282:1373	A new, green, simple and efficient absorbent for the adsorption of oils and organic solvents is provided.
34694728	3	45	dep	hydrophobicity	803:816	arg1	angle					833:837	water contact angle	819:837	water contact angle of 140°	819:845	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	2	46	theme	porous	351:356	arg1	aerogel					376:382	porous super-hydrophobic aerogel	351:382	porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material	351:458	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	2	46	theme	porous	351:356	arg1	montmorillonite					516:530	montmorillonite	516:530	montmorillonite (MMT)	516:536	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	2	46	theme	porous	351:356	arg1	alcohol					471:477	polyvinyl alcohol	461:477	polyvinyl alcohol (PVA) as the cross-linking agent	461:510	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	2	47	theme	polyvinyl	461:469	arg1	alcohol					471:477	polyvinyl alcohol	461:477	polyvinyl alcohol (PVA) as the cross-linking agent	461:510	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	2	47	theme	polyvinyl	461:469	arg1	aerogel					376:382	porous super-hydrophobic aerogel	351:382	porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material	351:458	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	2	47	theme	polyvinyl	461:469	arg1	PVA					480:482	PVA	480:482	PVA	480:482	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	6	48	theme	%	1179:1179	arg1	strain					1181:1186	70 % strain	1176:1186	70 % strain	1176:1186	More importantly, the composite aerogel had high strength, whose compressive stress at 70 % strain reached 0.15 MPa and could bear over 1290 times its weight without deformation after 2 weeks.
34694728	7	49	theme	new	1284:1286	arg1	absorbent					1317:1325	A new, green, simple and efficient absorbent	1282:1325	A new, green, simple and efficient absorbent for the adsorption of oils and organic solvents	1282:1373	A new, green, simple and efficient absorbent for the adsorption of oils and organic solvents is provided.
34694728	6	50	from	strain	1181:1186	arg1	stress					1166:1171	compressive stress	1154:1171	compressive stress at 70 % strain	1154:1186	More importantly, the composite aerogel had high strength, whose compressive stress at 70 % strain reached 0.15 MPa and could bear over 1290 times its weight without deformation after 2 weeks.
34694728	6	51	theme	compressive	1154:1164	arg1	stress					1166:1171	compressive stress	1154:1171	compressive stress at 70 % strain	1154:1186	More importantly, the composite aerogel had high strength, whose compressive stress at 70 % strain reached 0.15 MPa and could bear over 1290 times its weight without deformation after 2 weeks.
34694728	4	52	theme	good	886:889	arg1	effect					902:907	a good adsorption effect	884:907	a good adsorption effect on different oils and organic solutions	884:947	Notably, the composite aerogel has a good adsorption effect on different oils and organic solutions, and its adsorption capacity can reach 40-68 times of its initial weight.
34694728	6	53	theme	70	1176:1177	arg1	%					1179:1179	%	1179:1179	%	1179:1179	More importantly, the composite aerogel had high strength, whose compressive stress at 70 % strain reached 0.15 MPa and could bear over 1290 times its weight without deformation after 2 weeks.
34694728	3	54	theme	good	798:801	arg1	hydrophobicity					803:816	good hydrophobicity	798:816	good hydrophobicity (water contact angle of 140°)	798:846	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	7	55	theme	organic	1358:1364	arg1	solvents					1366:1373	organic solvents	1358:1373	organic solvents	1358:1373	A new, green, simple and efficient absorbent for the adsorption of oils and organic solvents is provided.
34694728	3	56	theme	prepared	649:656	arg1	aerogel					668:674	The prepared composite aerogel	645:674	The prepared composite aerogel	645:674	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	7	57	theme	simple	1296:1301	arg1	absorbent					1317:1325	A new, green, simple and efficient absorbent	1282:1325	A new, green, simple and efficient absorbent for the adsorption of oils and organic solvents	1282:1373	A new, green, simple and efficient absorbent for the adsorption of oils and organic solvents is provided.
34694728	1	58	theme	oil	165:167	arg1	spill					169:173	oil spill	165:173	oil spill	165:173	Nowadays, the problem of oil spill and organic solvent pollution has become more and more serious, and developing a green and efficient treatment method has become a research hotspot.
34694728	2	59	theme	cross-linking	492:504	arg1	agent					506:510	the cross-linking agent	488:510	the cross-linking agent	488:510	Herein, the preparation of porous super-hydrophobic aerogel by directional freezing with cellulose nanofibre (CNF) as the base material, polyvinyl alcohol (PVA) as the cross-linking agent and montmorillonite (MMT) as the modifier and filler, followed by hydrophobic treatment with chemical vapour deposition is reported.
34694728	3	60	theme	composite	658:666	arg1	aerogel					668:674	The prepared composite aerogel	645:674	The prepared composite aerogel	645:674	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	1	61	theme	spill	169:173	arg1	Nowadays					140:147	Nowadays	140:147	Nowadays	140:147	Nowadays, the problem of oil spill and organic solvent pollution has become more and more serious, and developing a green and efficient treatment method has become a research hotspot.
34694728	1	61	theme	spill	169:173	arg1	problem					154:160	the problem	150:160	the problem of oil spill and organic solvent pollution	150:203	Nowadays, the problem of oil spill and organic solvent pollution has become more and more serious, and developing a green and efficient treatment method has become a research hotspot.
34694728	3	62	theme	140°	842:845	arg1	angle					833:837	water contact angle	819:837	water contact angle of 140°	819:845	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	0	63	theme	green	97:101	arg1	absorbents					103:112	green absorbents	97:112	green absorbents for oil/water separation	97:137	Directional, super-hydrophobic cellulose nanofiber/polyvinyl alcohol/montmorillonite aerogels as green absorbents for oil/water separation.
34694728	3	64	theme	network	722:728	arg1	structure					730:738	three-dimensional inter-perforation network structure	686:738	three-dimensional inter-perforation network structure	686:738	The prepared composite aerogel presented three-dimensional inter-perforation network structure, low density (26.52 mg⋅cm-3 ), high porosity (96.1 %) and good hydrophobicity (water contact angle of 140°).
34694728	0	65	dep	Directional	0:10	arg1	super-hydrophobic					13:29	super-hydrophobic	13:29	super-hydrophobic	13:29	Directional, super-hydrophobic cellulose nanofiber/polyvinyl alcohol/montmorillonite aerogels as green absorbents for oil/water separation.
34694728	1	66	theme	green	256:260	arg1	method					286:291	a green and efficient treatment method	254:291	a green and efficient treatment method	254:291	Nowadays, the problem of oil spill and organic solvent pollution has become more and more serious, and developing a green and efficient treatment method has become a research hotspot.
34802756	9	0	theme	fruit-waste-derived	1697:1715	arg1	aerogels					1727:1734	fruit-waste-derived composite aerogels	1697:1734	fruit-waste-derived composite aerogels	1697:1734	The present work promises the potential of 2D nanostructured layered materials and fruit-waste-derived composite aerogels for sustainable utilization in wastewater treatment, which can be an excellent step towards water security.
34802756	7	1	theme	XPS	1275:1277	arg1	measurements					1279:1290	FTIR, Raman, and XPS measurements	1258:1290	measurements	1279:1290	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	8	2	from	wastewater	1602:1611	arg1	removal					1567:1573	the adsorptive removal	1552:1573	the adsorptive removal of organic pollutants from wastewater	1552:1611	Moreover, the composite aerogel furnished an excellent recyclability for the adsorptive removal of organic pollutants from wastewater.
34802756	8	2	from	wastewater	1602:1611	arg1	pollutants					1586:1595	organic pollutants	1578:1595	organic pollutants from wastewater	1578:1611	Moreover, the composite aerogel furnished an excellent recyclability for the adsorptive removal of organic pollutants from wastewater.
34802756	1	3	theme	water	259:263	arg1	scarcity					265:272	water scarcity	259:272	water scarcity	259:272	A wide range of organic pollutants in industrial effluents, agricultural runoff, and domestic discharges are exacerbating water scarcity, leading to water-borne ailments, and adversely affecting the marine ecosystem and biodiversity.
34802756	9	4	theme	sustainable	1740:1750	arg1	utilization					1752:1762	sustainable utilization	1740:1762	sustainable utilization	1740:1762	The present work promises the potential of 2D nanostructured layered materials and fruit-waste-derived composite aerogels for sustainable utilization in wastewater treatment, which can be an excellent step towards water security.
34802756	9	4	theme	sustainable	1740:1750	arg1	step					1815:1818	an excellent step	1802:1818	an excellent step towards water security	1802:1841	The present work promises the potential of 2D nanostructured layered materials and fruit-waste-derived composite aerogels for sustainable utilization in wastewater treatment, which can be an excellent step towards water security.
34802756	7	5	theme	dyes	1462:1465	arg1	adsorption					1440:1449	the adsorption	1436:1449	the adsorption of organic dyes by the CGA	1436:1476	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	6	theme	dipole-dipole	1348:1360	arg1	interactions					1334:1345	electrostatic, n-π, π-π, cation-π interactions	1300:1345	electrostatic, n-π, π-π, cation-π interactions	1300:1345	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	6	theme	dipole-dipole	1348:1360	arg1	hydrogen					1362:1369	dipole-dipole hydrogen	1348:1369	dipole-dipole hydrogen	1348:1369	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	6	theme	dipole-dipole	1348:1360	arg1	pathways					1423:1430	major interactive pathways	1405:1430	major interactive pathways for the adsorption of organic dyes by the CGA	1405:1476	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	6	theme	dipole-dipole	1348:1360	arg1	linkages					1393:1400	Yoshida hydrogen linkages	1376:1400	Yoshida hydrogen linkages	1376:1400	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	7	theme	spectroscopic	1226:1238	arg1	analyses					1240:1247	The spectroscopic analyses	1222:1247	The spectroscopic analyses based on FTIR, Raman, and XPS measurements	1222:1290	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	4	8	theme	oxide	910:914	arg1	aerogel					926:932	the cellulose-graphene oxide composite aerogel	887:932	the cellulose-graphene oxide composite aerogel (CGA)	887:938	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	4	8	theme	oxide	910:914	arg1	CGA					935:937	CGA	935:937	CGA	935:937	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	6	9	theme	adsorption	1202:1211	arg1	process					1213:1219	the adsorption process	1198:1219	the adsorption process	1198:1219	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	3	10	theme	composite	558:566	arg1	aerogel					568:574	ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel	505:574	ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel	505:574	Herein, ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel is prepared by gelatinization of graphene oxide with fruit waste-derived cellulose.
34802756	9	11	theme	composite	1717:1725	arg1	aerogels					1727:1734	fruit-waste-derived composite aerogels	1697:1734	fruit-waste-derived composite aerogels	1697:1734	The present work promises the potential of 2D nanostructured layered materials and fruit-waste-derived composite aerogels for sustainable utilization in wastewater treatment, which can be an excellent step towards water security.
34802756	0	12	theme	organic	123:129	arg1	dyes					131:134	organic dyes	123:134	organic dyes	123:134	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.
34802756	9	13	from	utilization	1752:1762	arg1	treatment					1778:1786	wastewater treatment	1767:1786	wastewater treatment	1767:1786	The present work promises the potential of 2D nanostructured layered materials and fruit-waste-derived composite aerogels for sustainable utilization in wastewater treatment, which can be an excellent step towards water security.
34802756	7	14	theme	major	1405:1409	arg1	interactions					1334:1345	electrostatic, n-π, π-π, cation-π interactions	1300:1345	electrostatic, n-π, π-π, cation-π interactions	1300:1345	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	14	theme	major	1405:1409	arg1	hydrogen					1362:1369	dipole-dipole hydrogen	1348:1369	dipole-dipole hydrogen	1348:1369	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	14	theme	major	1405:1409	arg1	pathways					1423:1430	major interactive pathways	1405:1430	major interactive pathways for the adsorption of organic dyes by the CGA	1405:1476	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	14	theme	major	1405:1409	arg1	linkages					1393:1400	Yoshida hydrogen linkages	1376:1400	Yoshida hydrogen linkages	1376:1400	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	9	15	theme	excellent	1805:1813	arg1	utilization					1752:1762	sustainable utilization	1740:1762	sustainable utilization	1740:1762	The present work promises the potential of 2D nanostructured layered materials and fruit-waste-derived composite aerogels for sustainable utilization in wastewater treatment, which can be an excellent step towards water security.
34802756	9	15	theme	excellent	1805:1813	arg1	step					1815:1818	an excellent step	1802:1818	an excellent step towards water security	1802:1841	The present work promises the potential of 2D nanostructured layered materials and fruit-waste-derived composite aerogels for sustainable utilization in wastewater treatment, which can be an excellent step towards water security.
34802756	8	16	theme	composite	1493:1501	arg1	aerogel					1503:1509	the composite aerogel	1489:1509	the composite aerogel	1489:1509	Moreover, the composite aerogel furnished an excellent recyclability for the adsorptive removal of organic pollutants from wastewater.
34802756	4	17	theme	oxide	747:751	arg1	sheets					753:758	graphene oxide sheets	738:758	graphene oxide sheets	738:758	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	3	18	theme	oxide	618:622	arg1	gelatinization					591:604	gelatinization	591:604	gelatinization of graphene oxide with fruit waste-derived cellulose	591:657	Herein, ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel is prepared by gelatinization of graphene oxide with fruit waste-derived cellulose.
34802756	7	19	theme	Yoshida	1376:1382	arg1	linkages					1393:1400	Yoshida hydrogen linkages	1376:1400	Yoshida hydrogen linkages	1376:1400	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	19	theme	Yoshida	1376:1382	arg1	interactions					1334:1345	electrostatic, n-π, π-π, cation-π interactions	1300:1345	electrostatic, n-π, π-π, cation-π interactions	1300:1345	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	19	theme	Yoshida	1376:1382	arg1	pathways					1423:1430	major interactive pathways	1405:1430	major interactive pathways for the adsorption of organic dyes by the CGA	1405:1476	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	19	theme	Yoshida	1376:1382	arg1	hydrogen					1362:1369	dipole-dipole hydrogen	1348:1369	dipole-dipole hydrogen	1348:1369	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	0	20	theme	adsorption	69:78	arg1	pathways					80:87	Plausible adsorption pathways	59:87	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.	0:135	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.
34802756	8	21	theme	excellent	1524:1532	arg1	recyclability					1534:1546	an excellent recyclability	1521:1546	an excellent recyclability for the adsorptive removal of organic pollutants from wastewater	1521:1611	Moreover, the composite aerogel furnished an excellent recyclability for the adsorptive removal of organic pollutants from wastewater.
34802756	4	22	theme	cellulosic	714:723	arg1	skeleton					725:732	interconnecting cellulosic skeleton	698:732	interconnecting cellulosic skeleton	698:732	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	3	23	with	oxide	618:622	arg1	cellulose					649:657	fruit waste-derived cellulose	629:657	fruit waste-derived cellulose	629:657	Herein, ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel is prepared by gelatinization of graphene oxide with fruit waste-derived cellulose.
34802756	1	24	theme	organic	153:159	arg1	pollutants					161:170	organic pollutants	153:170	organic pollutants	153:170	A wide range of organic pollutants in industrial effluents, agricultural runoff, and domestic discharges are exacerbating water scarcity, leading to water-borne ailments, and adversely affecting the marine ecosystem and biodiversity.
34802756	7	25	dep	electrostatic	1300:1312	arg1	n-π					1315:1317	n-π	1315:1317	n-π	1315:1317	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	25	dep	electrostatic	1300:1312	arg1	cation-π					1325:1332	cation-π	1325:1332	cation-π	1325:1332	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	25	dep	electrostatic	1300:1312	arg1	π-π					1320:1322	π-π	1320:1322	π-π	1320:1322	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	26	theme	FTIR	1258:1261	arg1	Raman					1264:1268	FTIR, Raman, and XPS measurements	1258:1290	Raman	1264:1268	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	6	27	dep	size	1064:1067	arg1	The					1060:1062	The	1060:1062	The	1060:1062	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	2	28	theme	sustainable	386:396	arg1	materials					418:426	The efficient, sustainable, and cost-effective materials	371:426	The efficient, sustainable, and cost-effective materials	371:426	The efficient, sustainable, and cost-effective materials need to be addressed urgently for the removal of organic pollutants.
34802756	0	29	theme	Fruit	0:4	arg1	aerogels					49:56	Fruit waste-derived cellulose and graphene-based aerogels	0:56	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.	0:135	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.
34802756	9	30	theme	present	1618:1624	arg1	work					1626:1629	The present work	1614:1629	The present work	1614:1629	The present work promises the potential of 2D nanostructured layered materials and fruit-waste-derived composite aerogels for sustainable utilization in wastewater treatment, which can be an excellent step towards water security.
34802756	6	31	theme	organic	1104:1110	arg1	dyes					1112:1115	organic dyes	1104:1115	organic dyes	1104:1115	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	8	32	theme	pollutants	1586:1595	arg1	removal					1567:1573	the adsorptive removal	1552:1573	the adsorptive removal of organic pollutants from wastewater	1552:1611	Moreover, the composite aerogel furnished an excellent recyclability for the adsorptive removal of organic pollutants from wastewater.
34802756	4	33	theme	bonding	773:779	arg1	network					781:787	hydrogen bonding network	764:787	hydrogen bonding network	764:787	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	0	34	theme	cellulose	20:28	arg1	aerogels					49:56	Fruit waste-derived cellulose and graphene-based aerogels	0:56	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.	0:135	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.
34802756	1	35	theme	water-borne	286:296	arg1	ailments					298:305	water-borne ailments	286:305	water-borne ailments	286:305	A wide range of organic pollutants in industrial effluents, agricultural runoff, and domestic discharges are exacerbating water scarcity, leading to water-borne ailments, and adversely affecting the marine ecosystem and biodiversity.
34802756	5	36	theme	accessible	1003:1012	arg1	sites					1022:1026	easily accessible surface sites	996:1026	easily accessible surface sites distributed throughout the CGA	996:1057	Consequently, organic dyes are efficiently adsorbed by easily accessible surface sites distributed throughout the CGA.
34802756	2	37	theme	organic	477:483	arg1	pollutants					485:494	organic pollutants	477:494	organic pollutants	477:494	The efficient, sustainable, and cost-effective materials need to be addressed urgently for the removal of organic pollutants.
34802756	6	38	theme	chemical	1082:1089	arg1	structure					1091:1099	chemical structure	1082:1099	chemical structure	1082:1099	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	4	39	theme	organic	843:849	arg1	wastewater					865:874	organic dyes-enriched wastewater	843:874	organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA)	843:938	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	0	40	theme	graphene-based	34:47	arg1	aerogels					49:56	Fruit waste-derived cellulose and graphene-based aerogels	0:56	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.	0:135	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.
34802756	3	41	theme	fruit	629:633	arg1	cellulose					649:657	fruit waste-derived cellulose	629:657	fruit waste-derived cellulose	629:657	Herein, ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel is prepared by gelatinization of graphene oxide with fruit waste-derived cellulose.
34802756	4	42	theme	wastewater	865:874	arg1	diffusion					830:838	diffusion	830:838	diffusion	830:838	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	4	42	theme	wastewater	865:874	arg1	transport					816:824	transport	816:824	transport	816:824	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	9	43	theme	layered	1675:1681	arg1	materials					1683:1691	nanostructured layered materials	1660:1691	nanostructured layered materials	1660:1691	The present work promises the potential of 2D nanostructured layered materials and fruit-waste-derived composite aerogels for sustainable utilization in wastewater treatment, which can be an excellent step towards water security.
34802756	6	44	theme	surface	1161:1167	arg1	CGA					1185:1187	CGA	1185:1187	CGA	1185:1187	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	6	44	theme	surface	1161:1167	arg1	sites					1176:1180	accessible surface active sites	1150:1180	accessible surface active sites	1150:1180	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	2	45	theme	efficient	375:383	arg1	materials					418:426	The efficient, sustainable, and cost-effective materials	371:426	The efficient, sustainable, and cost-effective materials	371:426	The efficient, sustainable, and cost-effective materials need to be addressed urgently for the removal of organic pollutants.
34802756	8	46	from	removal	1567:1573	arg1	wastewater					1602:1611	wastewater	1602:1611	wastewater	1602:1611	Moreover, the composite aerogel furnished an excellent recyclability for the adsorptive removal of organic pollutants from wastewater.
34802756	7	47	theme	electrostatic	1300:1312	arg1	interactions					1334:1345	electrostatic, n-π, π-π, cation-π interactions	1300:1345	electrostatic, n-π, π-π, cation-π interactions	1300:1345	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	47	theme	electrostatic	1300:1312	arg1	hydrogen					1362:1369	dipole-dipole hydrogen	1348:1369	dipole-dipole hydrogen	1348:1369	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	47	theme	electrostatic	1300:1312	arg1	pathways					1423:1430	major interactive pathways	1405:1430	major interactive pathways for the adsorption of organic dyes by the CGA	1405:1476	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	47	theme	electrostatic	1300:1312	arg1	linkages					1393:1400	Yoshida hydrogen linkages	1376:1400	Yoshida hydrogen linkages	1376:1400	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	3	48	theme	ultra-light	505:515	arg1	aerogel					568:574	ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel	505:574	ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel	505:574	Herein, ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel is prepared by gelatinization of graphene oxide with fruit waste-derived cellulose.
34802756	4	49	theme	composite	916:924	arg1	aerogel					926:932	the cellulose-graphene oxide composite aerogel	887:932	the cellulose-graphene oxide composite aerogel (CGA)	887:938	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	4	49	theme	composite	916:924	arg1	CGA					935:937	CGA	935:937	CGA	935:937	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	6	50	theme	textural	1128:1135	arg1	features					1137:1144	textural features	1128:1144	textural features	1128:1144	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	3	51	link	waste-derived	635:647	arg1	cellulose					649:657	fruit waste-derived cellulose	629:657	fruit waste-derived cellulose	629:657	Herein, ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel is prepared by gelatinization of graphene oxide with fruit waste-derived cellulose.
34802756	3	52	theme	porous	543:548	arg1	aerogel					568:574	ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel	505:574	ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel	505:574	Herein, ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel is prepared by gelatinization of graphene oxide with fruit waste-derived cellulose.
34802756	0	53	link	waste-derived	6:18	arg1	aerogels					49:56	Fruit waste-derived cellulose and graphene-based aerogels	0:56	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.	0:135	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.
34802756	1	54	theme	pollutants	161:170	arg1	discharges					231:240	domestic discharges	222:240	domestic discharges	222:240	A wide range of organic pollutants in industrial effluents, agricultural runoff, and domestic discharges are exacerbating water scarcity, leading to water-borne ailments, and adversely affecting the marine ecosystem and biodiversity.
34802756	1	54	theme	pollutants	161:170	arg1	range					144:148	A wide range	137:148	A wide range of organic pollutants in industrial effluents	137:194	A wide range of organic pollutants in industrial effluents, agricultural runoff, and domestic discharges are exacerbating water scarcity, leading to water-borne ailments, and adversely affecting the marine ecosystem and biodiversity.
34802756	1	55	theme	industrial	175:184	arg1	effluents					186:194	industrial effluents	175:194	industrial effluents	175:194	A wide range of organic pollutants in industrial effluents, agricultural runoff, and domestic discharges are exacerbating water scarcity, leading to water-borne ailments, and adversely affecting the marine ecosystem and biodiversity.
34802756	4	56	theme	cellulose-graphene	891:908	arg1	aerogel					926:932	the cellulose-graphene oxide composite aerogel	887:932	the cellulose-graphene oxide composite aerogel (CGA)	887:938	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	4	56	theme	cellulose-graphene	891:908	arg1	CGA					935:937	CGA	935:937	CGA	935:937	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	7	57	theme	organic	1454:1460	arg1	dyes					1462:1465	organic dyes	1454:1465	organic dyes	1454:1465	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	4	58	theme	macroscopic	664:674	arg1	porosity					676:683	The macroscopic porosity	660:683	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network	660:787	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	0	59	theme	dyes	131:134	arg1	removal					112:118	fast and efficient removal	93:118	fast and efficient removal of organic dyes	93:134	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.
34802756	6	60	theme	CGA	1185:1187	arg1	CGA					1185:1187	CGA	1185:1187	CGA	1185:1187	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	6	60	theme	CGA	1185:1187	arg1	sites					1176:1180	accessible surface active sites	1150:1180	accessible surface active sites	1150:1180	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	6	60	theme	CGA	1185:1187	arg1	features					1137:1144	textural features	1128:1144	textural features	1128:1144	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	9	61	theme	wastewater	1767:1776	arg1	treatment					1778:1786	wastewater treatment	1767:1786	wastewater treatment	1767:1786	The present work promises the potential of 2D nanostructured layered materials and fruit-waste-derived composite aerogels for sustainable utilization in wastewater treatment, which can be an excellent step towards water security.
34802756	1	62	from	discharges	231:240	arg1	effluents					186:194	industrial effluents	175:194	industrial effluents	175:194	A wide range of organic pollutants in industrial effluents, agricultural runoff, and domestic discharges are exacerbating water scarcity, leading to water-borne ailments, and adversely affecting the marine ecosystem and biodiversity.
34802756	5	63	theme	organic	955:961	arg1	dyes					963:966	organic dyes	955:966	organic dyes	955:966	Consequently, organic dyes are efficiently adsorbed by easily accessible surface sites distributed throughout the CGA.
34802756	7	64	theme	interactive	1411:1421	arg1	interactions					1334:1345	electrostatic, n-π, π-π, cation-π interactions	1300:1345	electrostatic, n-π, π-π, cation-π interactions	1300:1345	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	64	theme	interactive	1411:1421	arg1	hydrogen					1362:1369	dipole-dipole hydrogen	1348:1369	dipole-dipole hydrogen	1348:1369	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	64	theme	interactive	1411:1421	arg1	pathways					1423:1430	major interactive pathways	1405:1430	major interactive pathways for the adsorption of organic dyes by the CGA	1405:1476	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	64	theme	interactive	1411:1421	arg1	linkages					1393:1400	Yoshida hydrogen linkages	1376:1400	Yoshida hydrogen linkages	1376:1400	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	3	65	theme	graphene	609:616	arg1	oxide					618:622	graphene oxide	609:622	graphene oxide with fruit waste-derived cellulose	609:657	Herein, ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel is prepared by gelatinization of graphene oxide with fruit waste-derived cellulose.
34802756	4	66	theme	graphene	738:745	arg1	sheets					753:758	graphene oxide sheets	738:758	graphene oxide sheets	738:758	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	1	67	theme	wide	139:142	arg1	range					144:148	A wide range	137:148	A wide range of organic pollutants in industrial effluents	137:194	A wide range of organic pollutants in industrial effluents, agricultural runoff, and domestic discharges are exacerbating water scarcity, leading to water-borne ailments, and adversely affecting the marine ecosystem and biodiversity.
34802756	9	68	theme	water	1828:1832	arg1	security					1834:1841	water security	1828:1841	water security	1828:1841	The present work promises the potential of 2D nanostructured layered materials and fruit-waste-derived composite aerogels for sustainable utilization in wastewater treatment, which can be an excellent step towards water security.
34802756	7	69	theme	hydrogen	1384:1391	arg1	linkages					1393:1400	Yoshida hydrogen linkages	1376:1400	Yoshida hydrogen linkages	1376:1400	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	69	theme	hydrogen	1384:1391	arg1	interactions					1334:1345	electrostatic, n-π, π-π, cation-π interactions	1300:1345	electrostatic, n-π, π-π, cation-π interactions	1300:1345	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	69	theme	hydrogen	1384:1391	arg1	pathways					1423:1430	major interactive pathways	1405:1430	major interactive pathways for the adsorption of organic dyes by the CGA	1405:1476	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	7	69	theme	hydrogen	1384:1391	arg1	hydrogen					1362:1369	dipole-dipole hydrogen	1348:1369	dipole-dipole hydrogen	1348:1369	The spectroscopic analyses based on FTIR, Raman, and XPS measurements suggest electrostatic, n-π, π-π, cation-π interactions, dipole-dipole hydrogen, and Yoshida hydrogen linkages as major interactive pathways for the adsorption of organic dyes by the CGA.
34802756	0	70	theme	fast	93:96	arg1	removal					112:118	fast and efficient removal	93:118	fast and efficient removal of organic dyes	93:134	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.
34802756	1	71	theme	marine	336:341	arg1	ecosystem					343:351	the marine ecosystem	332:351	the marine ecosystem	332:351	A wide range of organic pollutants in industrial effluents, agricultural runoff, and domestic discharges are exacerbating water scarcity, leading to water-borne ailments, and adversely affecting the marine ecosystem and biodiversity.
34802756	2	72	theme	pollutants	485:494	arg1	removal					466:472	the removal	462:472	the removal of organic pollutants	462:494	The efficient, sustainable, and cost-effective materials need to be addressed urgently for the removal of organic pollutants.
34802756	4	73	theme	interconnecting	698:712	arg1	skeleton					725:732	interconnecting cellulosic skeleton	698:732	interconnecting cellulosic skeleton	698:732	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	0	74	theme	efficient	102:110	arg1	removal					112:118	fast and efficient removal	93:118	fast and efficient removal of organic dyes	93:134	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.
34802756	5	75	theme	surface	1014:1020	arg1	sites					1022:1026	easily accessible surface sites	996:1026	easily accessible surface sites distributed throughout the CGA	996:1057	Consequently, organic dyes are efficiently adsorbed by easily accessible surface sites distributed throughout the CGA.
34802756	1	76	from	range	144:148	arg1	effluents					186:194	industrial effluents	175:194	industrial effluents	175:194	A wide range of organic pollutants in industrial effluents, agricultural runoff, and domestic discharges are exacerbating water scarcity, leading to water-borne ailments, and adversely affecting the marine ecosystem and biodiversity.
34802756	8	77	theme	organic	1578:1584	arg1	pollutants					1586:1595	organic pollutants	1578:1595	organic pollutants from wastewater	1578:1611	Moreover, the composite aerogel furnished an excellent recyclability for the adsorptive removal of organic pollutants from wastewater.
34802756	4	78	theme	ample	798:802	arg1	avenues					804:810	ample avenues	798:810	ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA)	798:938	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	0	79	theme	waste-derived	6:18	arg1	aerogels					49:56	Fruit waste-derived cellulose and graphene-based aerogels	0:56	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.	0:135	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.
34802756	3	80	dep	ultra-light	505:515	arg1	%					555:555	96.4%	551:555	96.4%	551:555	Herein, ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel is prepared by gelatinization of graphene oxide with fruit waste-derived cellulose.
34802756	3	80	dep	ultra-light	505:515	arg1	0.018 g.cm-3					518:529	0.018 g.cm-3	518:529	0.018 g.cm-3	518:529	Herein, ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel is prepared by gelatinization of graphene oxide with fruit waste-derived cellulose.
34802756	8	81	theme	adsorptive	1556:1565	arg1	removal					1567:1573	the adsorptive removal	1552:1573	the adsorptive removal of organic pollutants from wastewater	1552:1611	Moreover, the composite aerogel furnished an excellent recyclability for the adsorptive removal of organic pollutants from wastewater.
34802756	6	82	theme	dyes	1112:1115	arg1	structure					1091:1099	chemical structure	1082:1099	chemical structure	1082:1099	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	6	82	theme	dyes	1112:1115	arg1	charge					1070:1075	charge	1070:1075	charge	1070:1075	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	6	82	theme	dyes	1112:1115	arg1	size					1064:1067	size	1064:1067	size	1064:1067	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	3	83	theme	waste-derived	635:647	arg1	cellulose					649:657	fruit waste-derived cellulose	629:657	fruit waste-derived cellulose	629:657	Herein, ultra-light (0.018 g.cm-3) and highly porous (96.4%) composite aerogel is prepared by gelatinization of graphene oxide with fruit waste-derived cellulose.
34802756	4	84	theme	hydrogen	764:771	arg1	network					781:787	hydrogen bonding network	764:787	hydrogen bonding network	764:787	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	9	85	link	fruit-waste-derived	1697:1715	arg1	aerogels					1727:1734	fruit-waste-derived composite aerogels	1697:1734	fruit-waste-derived composite aerogels	1697:1734	The present work promises the potential of 2D nanostructured layered materials and fruit-waste-derived composite aerogels for sustainable utilization in wastewater treatment, which can be an excellent step towards water security.
34802756	2	86	theme	cost-effective	403:416	arg1	materials					418:426	The efficient, sustainable, and cost-effective materials	371:426	The efficient, sustainable, and cost-effective materials	371:426	The efficient, sustainable, and cost-effective materials need to be addressed urgently for the removal of organic pollutants.
34802756	0	87	theme	Plausible	59:67	arg1	pathways					80:87	Plausible adsorption pathways	59:87	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.	0:135	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.
34802756	0	88	dep	aerogels	49:56	arg1	pathways					80:87	Plausible adsorption pathways	59:87	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.	0:135	Fruit waste-derived cellulose and graphene-based aerogels: Plausible adsorption pathways for fast and efficient removal of organic dyes.
34802756	4	89	theme	dyes-enriched	851:863	arg1	wastewater					865:874	organic dyes-enriched wastewater	843:874	organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA)	843:938	The macroscopic porosity generated by interconnecting cellulosic skeleton and graphene oxide sheets via hydrogen bonding network provided ample avenues for transport and diffusion of organic dyes-enriched wastewater throughout the cellulose-graphene oxide composite aerogel (CGA).
34802756	9	90	theme	nanostructured	1660:1673	arg1	materials					1683:1691	nanostructured layered materials	1660:1691	nanostructured layered materials	1660:1691	The present work promises the potential of 2D nanostructured layered materials and fruit-waste-derived composite aerogels for sustainable utilization in wastewater treatment, which can be an excellent step towards water security.
34802756	6	91	theme	active	1169:1174	arg1	CGA					1185:1187	CGA	1185:1187	CGA	1185:1187	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	6	91	theme	active	1169:1174	arg1	sites					1176:1180	accessible surface active sites	1150:1180	accessible surface active sites	1150:1180	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	1	92	theme	domestic	222:229	arg1	discharges					231:240	domestic discharges	222:240	domestic discharges	222:240	A wide range of organic pollutants in industrial effluents, agricultural runoff, and domestic discharges are exacerbating water scarcity, leading to water-borne ailments, and adversely affecting the marine ecosystem and biodiversity.
34802756	6	93	theme	accessible	1150:1159	arg1	CGA					1185:1187	CGA	1185:1187	CGA	1185:1187	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34802756	6	93	theme	accessible	1150:1159	arg1	sites					1176:1180	accessible surface active sites	1150:1180	accessible surface active sites	1150:1180	The size, charge, and chemical structure of organic dyes along with textural features and accessible surface active sites of CGA governed the adsorption process.
34216844	8	0	theme	current	1053:1059	arg1	work					1061:1064	The current work	1049:1064	The current work	1049:1064	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	2	1	theme	product	373:379	arg1	yield					381:385	a high product yield	366:385	a high product yield	366:385	The Ag-β-CD composite was synthesized via a hydrothermal route, which resulted in a high product yield.
34216844	7	2	theme	nM	930:931	arg1	range					908:912	the concentration range	890:912	the concentration range of 0.1 nM to 50 nM	890:931	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	7	2	theme	nM	930:931	arg1	limit					941:945	the limit	937:945	the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation	937:1046	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	7	3	theme	linear	853:858	arg1	response					860:867	A linear response	851:867	A linear response	851:867	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	4	4	theme	pulse	557:561	arg1	DPV					576:578	DPV	576:578	DPV	576:578	The Ag-β-CD composite was used to detect ciprofloxacin by employing differential pulse voltammetry (DPV) and cyclic voltammetry (CV).
34216844	4	4	theme	pulse	557:561	arg1	voltammetry					563:573	differential pulse voltammetry	544:573	differential pulse voltammetry (DPV)	544:579	The Ag-β-CD composite was used to detect ciprofloxacin by employing differential pulse voltammetry (DPV) and cyclic voltammetry (CV).
34216844	5	5	theme	Ag-β-CD	614:620	arg1	electrode					631:639	The Ag-β-CD modified electrode	610:639	The Ag-β-CD modified electrode	610:639	The Ag-β-CD modified electrode displayed excellent specificity towards the electro-oxidation of ciprofloxacin.
34216844	1	6	theme	sheep	184:188	arg1	serum					190:194	sheep serum	184:194	sheep serum	184:194	This study emphases on electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle modified β-cyclodextrin (Ag-β-CD) composite.
34216844	8	7	from	detection	1178:1186	arg1	serum					1227:1231	spiked sheep blood serum	1208:1231	spiked sheep blood serum	1208:1231	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	8	7	from	detection	1178:1186	arg1	samples					1259:1265	domestic runoff water samples	1237:1265	domestic runoff water samples	1237:1265	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	8	8	theme	ciprofloxacin	1191:1203	arg1	detection					1178:1186	rapid and sensitive detection	1158:1186	rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples	1158:1265	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	4	9	theme	differential	544:555	arg1	DPV					576:578	DPV	576:578	DPV	576:578	The Ag-β-CD composite was used to detect ciprofloxacin by employing differential pulse voltammetry (DPV) and cyclic voltammetry (CV).
34216844	4	9	theme	differential	544:555	arg1	voltammetry					563:573	differential pulse voltammetry	544:573	differential pulse voltammetry (DPV)	544:579	The Ag-β-CD composite was used to detect ciprofloxacin by employing differential pulse voltammetry (DPV) and cyclic voltammetry (CV).
34216844	2	10	theme	high	368:371	arg1	yield					381:385	a high product yield	366:385	a high product yield	366:385	The Ag-β-CD composite was synthesized via a hydrothermal route, which resulted in a high product yield.
34216844	5	11	theme	modified	622:629	arg1	electrode					631:639	The Ag-β-CD modified electrode	610:639	The Ag-β-CD modified electrode	610:639	The Ag-β-CD modified electrode displayed excellent specificity towards the electro-oxidation of ciprofloxacin.
34216844	0	12	theme	ciprofloxacin	100:112	arg1	detection					87:95	highly sensitive detection	70:95	highly sensitive detection of ciprofloxacin	70:112	One-pot synthesis of β-cyclodextrin modified silver nanoparticles for highly sensitive detection of ciprofloxacin.
34216844	9	13	theme	such	1374:1377	arg1	samples					1379:1385	such samples	1374:1385	such samples	1374:1385	High sensitivity and low LOD results illustrate good practicability for the detection of ciprofloxacin in such samples in the near future.
34216844	7	14	from	nM	975:976	arg1	LOD					961:963	LOD	961:963	LOD	961:963	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	7	14	from	nM	975:976	arg1	range					908:912	the concentration range	890:912	the concentration range of 0.1 nM to 50 nM	890:931	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	7	14	from	nM	975:976	arg1	detection					950:958	detection	950:958	detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation	950:1046	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	7	14	from	nM	975:976	arg1	limit					941:945	the limit	937:945	the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation	937:1046	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	9	15	from	detection	1344:1352	arg1	samples					1379:1385	such samples	1374:1385	such samples	1374:1385	High sensitivity and low LOD results illustrate good practicability for the detection of ciprofloxacin in such samples in the near future.
34216844	8	16	theme	spiked	1208:1213	arg1	serum					1227:1231	spiked sheep blood serum	1208:1231	spiked sheep blood serum	1208:1231	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	5	17	theme	excellent	651:659	arg1	specificity					661:671	excellent specificity	651:671	excellent specificity towards the electro-oxidation of ciprofloxacin	651:718	The Ag-β-CD modified electrode displayed excellent specificity towards the electro-oxidation of ciprofloxacin.
34216844	8	18	contain	has	1066:1068	arg1	work					1061:1064	The current work	1049:1064	The current work	1049:1064	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	8	18	contain	has	1066:1068	arg2	nanocomposite					1113:1125	a rationally synthesized and characterized nanocomposite	1070:1125	a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples	1070:1265	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	8	19	theme	runoff	1246:1251	arg1	samples					1259:1265	domestic runoff water samples	1237:1265	domestic runoff water samples	1237:1265	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	6	20	theme	best	750:753	arg1	response					755:762	the best response	746:762	the best response towards the electro-oxidation of ciprofloxacin near the human physiological pH of 7.5	746:848	Further, the sensor gave the best response towards the electro-oxidation of ciprofloxacin near the human physiological pH of 7.5.
34216844	9	21	theme	ciprofloxacin	1357:1369	arg1	detection					1344:1352	the detection	1340:1352	the detection of ciprofloxacin in such samples	1340:1385	High sensitivity and low LOD results illustrate good practicability for the detection of ciprofloxacin in such samples in the near future.
34216844	0	22	theme	silver	45:50	arg1	nanoparticles					52:64	silver nanoparticles	45:64	silver nanoparticles for highly sensitive detection of ciprofloxacin	45:112	One-pot synthesis of β-cyclodextrin modified silver nanoparticles for highly sensitive detection of ciprofloxacin.
34216844	6	23	theme	7.5	846:848	arg1	pH					840:841	the human physiological pH	816:841	the human physiological pH of 7.5	816:848	Further, the sensor gave the best response towards the electro-oxidation of ciprofloxacin near the human physiological pH of 7.5.
34216844	8	24	theme	sheep	1215:1219	arg1	serum					1227:1231	spiked sheep blood serum	1208:1231	spiked sheep blood serum	1208:1231	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	7	25	theme	concentration	894:906	arg1	range					908:912	the concentration range	890:912	the concentration range of 0.1 nM to 50 nM	890:931	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	3	26	theme	spectral	406:413	arg1	characterizations					415:431	Morphological and spectral characterizations	388:431	Morphological and spectral characterizations of the Ag-β-CD composite	388:456	Morphological and spectral characterizations of the Ag-β-CD composite were carried out.
34216844	8	27	theme	sensitive	1168:1176	arg1	detection					1178:1186	rapid and sensitive detection	1158:1186	rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples	1158:1265	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	1	28	from	detection	154:162	arg1	serum					190:194	sheep serum	184:194	sheep serum	184:194	This study emphases on electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle modified β-cyclodextrin (Ag-β-CD) composite.
34216844	1	28	from	detection	154:162	arg1	water					207:211	runoff water	200:211	runoff water	200:211	This study emphases on electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle modified β-cyclodextrin (Ag-β-CD) composite.
34216844	1	29	theme	runoff	200:205	arg1	water					207:211	runoff water	200:211	runoff water	200:211	This study emphases on electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle modified β-cyclodextrin (Ag-β-CD) composite.
34216844	0	30	theme	One-pot	0:6	arg1	synthesis					8:16	One-pot synthesis	0:16	One-pot synthesis of β-cyclodextrin	0:34	One-pot synthesis of β-cyclodextrin modified silver nanoparticles for highly sensitive detection of ciprofloxacin.
34216844	4	31	theme	cyclic	585:590	arg1	CV					605:606	CV	605:606	CV	605:606	The Ag-β-CD composite was used to detect ciprofloxacin by employing differential pulse voltammetry (DPV) and cyclic voltammetry (CV).
34216844	4	31	theme	cyclic	585:590	arg1	voltammetry					592:602	cyclic voltammetry	585:602	cyclic voltammetry (CV)	585:607	The Ag-β-CD composite was used to detect ciprofloxacin by employing differential pulse voltammetry (DPV) and cyclic voltammetry (CV).
34216844	8	32	theme	synthesized	1083:1093	arg1	nanocomposite					1113:1125	a rationally synthesized and characterized nanocomposite	1070:1125	a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples	1070:1265	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	1	33	from	emphases	126:133	arg1	detection					154:162	electrochemical detection	138:162	electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle	138:237	This study emphases on electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle modified β-cyclodextrin (Ag-β-CD) composite.
34216844	0	34	theme	β-cyclodextrin	21:34	arg1	synthesis					8:16	One-pot synthesis	0:16	One-pot synthesis of β-cyclodextrin	0:34	One-pot synthesis of β-cyclodextrin modified silver nanoparticles for highly sensitive detection of ciprofloxacin.
34216844	7	35	theme	detection	950:958	arg1	range					908:912	the concentration range	890:912	the concentration range of 0.1 nM to 50 nM	890:931	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	7	35	theme	detection	950:958	arg1	limit					941:945	the limit	937:945	the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation	937:1046	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	6	36	theme	physiological	826:838	arg1	pH					840:841	the human physiological pH	816:841	the human physiological pH of 7.5	816:848	Further, the sensor gave the best response towards the electro-oxidation of ciprofloxacin near the human physiological pH of 7.5.
34216844	2	37	theme	hydrothermal	328:339	arg1	route					341:345	a hydrothermal route	326:345	a hydrothermal route	326:345	The Ag-β-CD composite was synthesized via a hydrothermal route, which resulted in a high product yield.
34216844	8	38	theme	characterized	1099:1111	arg1	nanocomposite					1113:1125	a rationally synthesized and characterized nanocomposite	1070:1125	a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples	1070:1265	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	4	39	theme	Ag-β-CD	480:486	arg1	composite					488:496	The Ag-β-CD composite	476:496	The Ag-β-CD composite	476:496	The Ag-β-CD composite was used to detect ciprofloxacin by employing differential pulse voltammetry (DPV) and cyclic voltammetry (CV).
34216844	1	40	theme	study	120:124	arg1	emphases					126:133	This study emphases	115:133	This study emphases on electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle	115:237	This study emphases on electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle modified β-cyclodextrin (Ag-β-CD) composite.
34216844	1	41	theme	silver	219:224	arg1	nanoparticle					226:237	silver nanoparticle	219:237	silver nanoparticle	219:237	This study emphases on electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle modified β-cyclodextrin (Ag-β-CD) composite.
34216844	3	42	theme	Ag-β-CD	440:446	arg1	composite					448:456	the Ag-β-CD composite	436:456	the Ag-β-CD composite	436:456	Morphological and spectral characterizations of the Ag-β-CD composite were carried out.
34216844	7	43	theme	0.1	917:919	arg1	nM					921:922	nM	921:922	nM	921:922	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	9	44	theme	High	1268:1271	arg1	sensitivity					1273:1283	High sensitivity	1268:1283	High sensitivity	1268:1283	High sensitivity and low LOD results illustrate good practicability for the detection of ciprofloxacin in such samples in the near future.
34216844	3	45	theme	composite	448:456	arg1	characterizations					415:431	Morphological and spectral characterizations	388:431	Morphological and spectral characterizations of the Ag-β-CD composite	388:456	Morphological and spectral characterizations of the Ag-β-CD composite were carried out.
34216844	8	46	theme	domestic	1237:1244	arg1	samples					1259:1265	domestic runoff water samples	1237:1265	domestic runoff water samples	1237:1265	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	9	47	theme	sensitivity	1273:1283	arg1	results					1297:1303	High sensitivity and low LOD results	1268:1303	High sensitivity and low LOD results	1268:1303	High sensitivity and low LOD results illustrate good practicability for the detection of ciprofloxacin in such samples in the near future.
34216844	3	48	theme	Morphological	388:400	arg1	characterizations					415:431	Morphological and spectral characterizations	388:431	Morphological and spectral characterizations of the Ag-β-CD composite	388:456	Morphological and spectral characterizations of the Ag-β-CD composite were carried out.
34216844	6	49	theme	human	820:824	arg1	pH					840:841	the human physiological pH	816:841	the human physiological pH of 7.5	816:848	Further, the sensor gave the best response towards the electro-oxidation of ciprofloxacin near the human physiological pH of 7.5.
34216844	8	50	theme	blood	1221:1225	arg1	serum					1227:1231	spiked sheep blood serum	1208:1231	spiked sheep blood serum	1208:1231	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	4	51	used	used	502:505	arg2	composite					488:496	The Ag-β-CD composite	476:496	The Ag-β-CD composite	476:496	The Ag-β-CD composite was used to detect ciprofloxacin by employing differential pulse voltammetry (DPV) and cyclic voltammetry (CV).
34216844	8	52	theme	high	1139:1142	arg1	potential					1144:1152	a very high potential	1132:1152	a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples	1132:1265	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	8	53	theme	water	1253:1257	arg1	samples					1259:1265	domestic runoff water samples	1237:1265	domestic runoff water samples	1237:1265	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	9	54	theme	low	1289:1291	arg1	LOD					1293:1295	low LOD	1289:1295	low LOD	1289:1295	High sensitivity and low LOD results illustrate good practicability for the detection of ciprofloxacin in such samples in the near future.
34216844	9	55	theme	LOD	1293:1295	arg1	results					1297:1303	High sensitivity and low LOD results	1268:1303	High sensitivity and low LOD results	1268:1303	High sensitivity and low LOD results illustrate good practicability for the detection of ciprofloxacin in such samples in the near future.
34216844	5	56	theme	ciprofloxacin	706:718	arg1	electro-oxidation					685:701	the electro-oxidation	681:701	the electro-oxidation of ciprofloxacin	681:718	The Ag-β-CD modified electrode displayed excellent specificity towards the electro-oxidation of ciprofloxacin.
34216844	7	57	dep	nM	921:922	arg1	to					924:925	to	924:925	to	924:925	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	2	58	theme	Ag-β-CD	288:294	arg1	composite					296:304	The Ag-β-CD composite	284:304	The Ag-β-CD composite	284:304	The Ag-β-CD composite was synthesized via a hydrothermal route, which resulted in a high product yield.
34216844	6	59	theme	ciprofloxacin	797:809	arg1	electro-oxidation					776:792	the electro-oxidation	772:792	the electro-oxidation of ciprofloxacin near the human physiological pH of 7.5	772:848	Further, the sensor gave the best response towards the electro-oxidation of ciprofloxacin near the human physiological pH of 7.5.
34216844	1	60	theme	electrochemical	138:152	arg1	detection					154:162	electrochemical detection	138:162	electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle	138:237	This study emphases on electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle modified β-cyclodextrin (Ag-β-CD) composite.
34216844	7	61	from	limit	941:945	arg1	nM					975:976	0.028 nM	969:976	0.028 nM	969:976	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	7	62	theme	ciprofloxacin	1024:1036	arg1	oxidation					1038:1046	ciprofloxacin oxidation	1024:1046	ciprofloxacin oxidation	1024:1046	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	7	63	from	range	908:912	arg1	nM					975:976	0.028 nM	969:976	0.028 nM	969:976	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	8	64	with	nanocomposite	1113:1125	arg1	potential					1144:1152	a very high potential	1132:1152	a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples	1132:1265	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	0	65	theme	sensitive	77:85	arg1	detection					87:95	highly sensitive detection	70:95	highly sensitive detection of ciprofloxacin	70:112	One-pot synthesis of β-cyclodextrin modified silver nanoparticles for highly sensitive detection of ciprofloxacin.
34216844	8	66	theme	rapid	1158:1162	arg1	detection					1178:1186	rapid and sensitive detection	1158:1186	rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples	1158:1265	The current work has a rationally synthesized and characterized nanocomposite with a very high potential for rapid and sensitive detection of ciprofloxacin in spiked sheep blood serum and domestic runoff water samples.
34216844	9	67	theme	good	1316:1319	arg1	practicability					1321:1334	good practicability	1316:1334	good practicability for the detection of ciprofloxacin in such samples	1316:1385	High sensitivity and low LOD results illustrate good practicability for the detection of ciprofloxacin in such samples in the near future.
34216844	7	68	with	detection	950:958	arg1	selectivity					1004:1014	selectivity	1004:1014	selectivity	1004:1014	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	7	68	with	detection	950:958	arg1	sensitivity					988:998	high sensitivity	983:998	high sensitivity	983:998	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	7	69	theme	high	983:986	arg1	sensitivity					988:998	high sensitivity	983:998	high sensitivity	983:998	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34216844	1	70	theme	ciprofloxacin	167:179	arg1	detection					154:162	electrochemical detection	138:162	electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle	138:237	This study emphases on electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle modified β-cyclodextrin (Ag-β-CD) composite.
34216844	7	71	theme	50	927:928	arg1	nM					921:922	nM	921:922	nM	921:922	A linear response was obtained between the concentration range of 0.1 nM to 50 nM and the limit of detection (LOD) at 0.028 nM with high sensitivity and selectivity towards ciprofloxacin oxidation.
34116226	6	0	theme	cell	1004:1007	arg1	functions					1009:1017	different cell functions	994:1017	different cell functions	994:1017	In our study, we used vLMW, LMW and HMW HA at different physiologically relevant concentrations, with a particular interest in correlating the mechanical and structural properties to different cell functions.
34116226	14	1	theme	tumor	2060:2064	arg1	microenvironment					2066:2081	the tumor microenvironment	2056:2081	the tumor microenvironment (TME)	2056:2087	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA) is a critical component of the tumor microenvironment (TME).
34116226	14	1	theme	tumor	2060:2064	arg1	TME					2084:2086	TME	2084:2086	TME	2084:2086	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA) is a critical component of the tumor microenvironment (TME).
34116226	12	2	theme	HA	1861:1862	arg1	weight					1874:1879	high HA molecular weight	1856:1879	high HA molecular weight	1856:1879	HA appears to have the effect of decreasing migration and increasing collagen network contraction, but only at high HA molecular weight.
34116226	15	3	from	Overproduction	2090:2103	arg1	TME					2118:2120	the TME	2114:2120	the TME	2114:2120	Overproduction of HA in the TME results in poor prognosis and collapse of blood vessels, inhibiting drug delivery.
34116226	7	4	theme	elastic	1024:1030	arg1	modulus					1032:1038	The elastic modulus	1020:1038	The elastic modulus	1020:1038	The elastic modulus, collagen network pore size and collagen fiber diameter increased with increasing HA concentration.
34116226	2	5	theme	HA	259:260	arg1	properties					245:254	the molecular weight (MW) dependent properties	209:254	the molecular weight (MW) dependent properties of HA	209:260	While the molecular weight (MW) dependent properties of HA can cause tumor-promoting and -repressing effects, the elevated levels of HA in the TME impedes drug delivery.
34116226	18	6	theme	cell	2448:2451	arg1	behavior					2453:2460	cancer cell behavior	2441:2460	cancer cell behavior	2441:2460	Understanding how HA degradation affects cancer cell behavior is critical for uncovering detrimental effects of this therapy.
34116226	19	7	theme	collagen-HA	2611:2621	arg1	networks					2633:2640	tumor-mimicking collagen-HA composite networks	2595:2640	tumor-mimicking collagen-HA composite networks	2595:2640	Very little is known about how HA MW affects cancer cell behavior in tumor-mimicking collagen-HA composite networks.
34116226	20	8	theme	collagen-HA	2684:2694	arg1	networks					2696:2703	collagen-HA networks	2684:2703	collagen-HA networks	2684:2703	Here we examine how MW and HA content in collagen-HA networks alter structural and mechanical properties to regulate cell migration and matrix remodeling in 3D TME-mimicking environments.
34116226	20	9	theme	TME-mimicking	2803:2815	arg1	environments					2817:2828	3D TME-mimicking environments	2800:2828	3D TME-mimicking environments	2800:2828	Here we examine how MW and HA content in collagen-HA networks alter structural and mechanical properties to regulate cell migration and matrix remodeling in 3D TME-mimicking environments.
34116226	8	10	theme	network	1162:1168	arg1	size					1175:1178	the collagen network pore size	1149:1178	the collagen network pore size	1149:1178	Although the collagen network pore size increased, these pores were filled with the bulky HA molecules.
34116226	14	11	theme	critical	2034:2041	arg1	STATEMENT					1986:1994	STATEMENT	1986:1994	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA)	1986:2027	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA) is a critical component of the tumor microenvironment (TME).
34116226	14	11	theme	critical	2034:2041	arg1	component					2043:2051	a critical component	2032:2051	a critical component of the tumor microenvironment (TME)	2032:2087	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA) is a critical component of the tumor microenvironment (TME).
34116226	15	12	theme	poor	2133:2136	arg1	prognosis					2138:2146	poor prognosis	2133:2146	poor prognosis	2133:2146	Overproduction of HA in the TME results in poor prognosis and collapse of blood vessels, inhibiting drug delivery.
34116226	2	13	from	levels	326:331	arg1	TME					346:348	the TME	342:348	the TME	342:348	While the molecular weight (MW) dependent properties of HA can cause tumor-promoting and -repressing effects, the elevated levels of HA in the TME impedes drug delivery.
34116226	7	14	theme	fiber	1081:1085	arg1	diameter					1087:1094	collagen fiber diameter	1072:1094	collagen fiber diameter	1072:1094	The elastic modulus, collagen network pore size and collagen fiber diameter increased with increasing HA concentration.
34116226	18	15	theme	HA	2418:2419	arg1	degradation					2421:2431	HA degradation	2418:2431	HA degradation	2418:2431	Understanding how HA degradation affects cancer cell behavior is critical for uncovering detrimental effects of this therapy.
34116226	19	16	theme	cancer	2571:2576	arg1	behavior					2583:2590	cancer cell behavior	2571:2590	cancer cell behavior in tumor-mimicking collagen-HA composite networks	2571:2640	Very little is known about how HA MW affects cancer cell behavior in tumor-mimicking collagen-HA composite networks.
34116226	1	17	theme	cancer	171:176	arg1	growth					178:183	cancer growth	171:183	cancer growth	171:183	Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates in cancer growth and invasiveness.
34116226	20	18	from	content	2673:2679	arg1	networks					2696:2703	collagen-HA networks	2684:2703	collagen-HA networks	2684:2703	Here we examine how MW and HA content in collagen-HA networks alter structural and mechanical properties to regulate cell migration and matrix remodeling in 3D TME-mimicking environments.
34116226	17	19	theme	molecular	2287:2295	arg1	MW					2305:2306	MW	2305:2306	MW	2305:2306	However, they lead to low molecular weight (MW) HA, altering the mechanical and structural properties of the TME and cancer cell behavior.
34116226	17	19	theme	molecular	2287:2295	arg1	weight					2297:2302	low molecular weight	2283:2302	low molecular weight (MW) HA	2283:2310	However, they lead to low molecular weight (MW) HA, altering the mechanical and structural properties of the TME and cancer cell behavior.
34116226	10	20	dep	concentrations	1608:1621	arg1	mL-1					1635:1638	2 and 4 mg mL-1	1624:1638	2 and 4 mg mL-1 [0.2 and 0.4%	1624:1652	Surprisingly, even though elastic modulus increased with HA molecular weight and concentration, gel compaction assays showed an increased degree of ECM compaction among HMW HA gels at high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%]).
34116226	13	21	from	changes	1896:1902	arg1	weight					1920:1925	HA molecular weight	1907:1925	HA molecular weight	1907:1925	Consequently, changes in HA molecular weight can have relatively large effects on cancer cell behavior.
34116226	12	22	theme	collagen	1814:1821	arg1	contraction					1831:1841	collagen network contraction	1814:1841	collagen network contraction	1814:1841	HA appears to have the effect of decreasing migration and increasing collagen network contraction, but only at high HA molecular weight.
34116226	6	23	dep	vLMW	833:836	arg1	HA					851:852	HA	851:852	HA	851:852	In our study, we used vLMW, LMW and HMW HA at different physiologically relevant concentrations, with a particular interest in correlating the mechanical and structural properties to different cell functions.
34116226	10	24	theme	ECM	1567:1569	arg1	compaction					1571:1580	ECM compaction	1567:1580	ECM compaction	1567:1580	Surprisingly, even though elastic modulus increased with HA molecular weight and concentration, gel compaction assays showed an increased degree of ECM compaction among HMW HA gels at high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%]).
34116226	2	25	theme	molecular	213:221	arg1	MW					231:232	MW	231:232	MW	231:232	While the molecular weight (MW) dependent properties of HA can cause tumor-promoting and -repressing effects, the elevated levels of HA in the TME impedes drug delivery.
34116226	2	25	theme	molecular	213:221	arg1	weight					223:228	molecular weight	213:228	molecular weight (MW)	213:233	While the molecular weight (MW) dependent properties of HA can cause tumor-promoting and -repressing effects, the elevated levels of HA in the TME impedes drug delivery.
34116226	5	26	theme	extracellular	772:784	arg1	ECM					794:796	ECM	794:796	ECM	794:796	Here we examine the influence of HA molecular weight on biophysical properties that regulate cell migration and extracellular matrix (ECM) remodeling.
34116226	5	26	theme	extracellular	772:784	arg1	matrix					786:791	extracellular matrix	772:791	extracellular matrix (ECM)	772:797	Here we examine the influence of HA molecular weight on biophysical properties that regulate cell migration and extracellular matrix (ECM) remodeling.
34116226	4	27	theme	biological	634:643	arg1	effects					645:651	the MW-dependent biological effects	617:651	the MW-dependent biological effects of HA	617:657	Therefore, it is critical to understand the MW-dependent biological effects of HA.
34116226	14	28	theme	SIGNIFICANCE	1999:2010	arg1	STATEMENT					1986:1994	STATEMENT	1986:1994	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA)	1986:2027	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA) is a critical component of the tumor microenvironment (TME).
34116226	14	28	theme	SIGNIFICANCE	1999:2010	arg1	component					2043:2051	a critical component	2032:2051	a critical component of the tumor microenvironment (TME)	2032:2087	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA) is a critical component of the tumor microenvironment (TME).
34116226	5	29	from	influence	680:688	arg1	properties					728:737	biophysical properties	716:737	biophysical properties that regulate cell migration and extracellular matrix (ECM) remodeling	716:808	Here we examine the influence of HA molecular weight on biophysical properties that regulate cell migration and extracellular matrix (ECM) remodeling.
34116226	3	30	theme	changes	506:512	arg1	unknown					568:574	unknown	568:574	unknown	568:574	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	3	30	theme	changes	506:512	arg1	consequences					490:501	the consequences	486:501	the consequences of changes in HA molecular weight and concentration	486:553	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	19	31	theme	composite	2623:2631	arg1	networks					2633:2640	tumor-mimicking collagen-HA composite networks	2595:2640	tumor-mimicking collagen-HA composite networks	2595:2640	Very little is known about how HA MW affects cancer cell behavior in tumor-mimicking collagen-HA composite networks.
34116226	18	32	theme	therapy	2517:2523	arg1	effects					2501:2507	detrimental effects	2489:2507	detrimental effects of this therapy	2489:2523	Understanding how HA degradation affects cancer cell behavior is critical for uncovering detrimental effects of this therapy.
34116226	13	33	theme	cancer	1964:1969	arg1	behavior					1976:1983	cancer cell behavior	1964:1983	cancer cell behavior	1964:1983	Consequently, changes in HA molecular weight can have relatively large effects on cancer cell behavior.
34116226	1	34	theme	tumor	121:125	arg1	TME					145:147	TME	145:147	TME	145:147	Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates in cancer growth and invasiveness.
34116226	1	34	theme	tumor	121:125	arg1	microenvironment					127:142	the tumor microenvironment	117:142	the tumor microenvironment (TME)	117:148	Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates in cancer growth and invasiveness.
34116226	13	35	contain	have	1931:1934	arg2	effects					1953:1959	relatively large effects	1936:1959	relatively large effects	1936:1959	Consequently, changes in HA molecular weight can have relatively large effects on cancer cell behavior.
34116226	13	35	contain	have	1931:1934	arg1	changes					1896:1902	changes	1896:1902	changes in HA molecular weight	1896:1925	Consequently, changes in HA molecular weight can have relatively large effects on cancer cell behavior.
34116226	6	36	theme	particular	915:924	arg1	interest					926:933	a particular interest	913:933	a particular interest in correlating the mechanical and structural properties to different cell functions	913:1017	In our study, we used vLMW, LMW and HMW HA at different physiologically relevant concentrations, with a particular interest in correlating the mechanical and structural properties to different cell functions.
34116226	8	37	theme	HA	1230:1231	arg1	molecules					1233:1241	the bulky HA molecules	1220:1241	the bulky HA molecules	1220:1241	Although the collagen network pore size increased, these pores were filled with the bulky HA molecules.
34116226	3	38	from	consequences	490:501	arg1	weight					530:535	HA molecular weight	517:535	HA molecular weight	517:535	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	3	38	from	consequences	490:501	arg1	concentration					541:553	concentration	541:553	concentration	541:553	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	0	39	from	migration	12:20	arg1	matrices					69:76	collagen-hyaluronan composite extracellular matrices	25:76	collagen-hyaluronan composite extracellular matrices	25:76	Cancer cell migration in collagen-hyaluronan composite extracellular matrices.
34116226	15	40	theme	vessels	2170:2176	arg1	collapse					2152:2159	collapse	2152:2159	collapse	2152:2159	Overproduction of HA in the TME results in poor prognosis and collapse of blood vessels, inhibiting drug delivery.
34116226	15	40	theme	vessels	2170:2176	arg1	prognosis					2138:2146	poor prognosis	2133:2146	poor prognosis	2133:2146	Overproduction of HA in the TME results in poor prognosis and collapse of blood vessels, inhibiting drug delivery.
34116226	10	41	dep	mL-1	1635:1638	arg1	%					1652:1652	[0.2 and 0.4%	1640:1652	2 and 4 mg mL-1 [0.2 and 0.4%	1624:1652	Surprisingly, even though elastic modulus increased with HA molecular weight and concentration, gel compaction assays showed an increased degree of ECM compaction among HMW HA gels at high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%]).
34116226	7	42	theme	HA	1122:1123	arg1	concentration					1125:1137	HA concentration	1122:1137	HA concentration	1122:1137	The elastic modulus, collagen network pore size and collagen fiber diameter increased with increasing HA concentration.
34116226	19	43	theme	tumor-mimicking	2595:2609	arg1	networks					2633:2640	tumor-mimicking collagen-HA composite networks	2595:2640	tumor-mimicking collagen-HA composite networks	2595:2640	Very little is known about how HA MW affects cancer cell behavior in tumor-mimicking collagen-HA composite networks.
34116226	20	44	from	remodeling	2786:2795	arg1	environments					2817:2828	3D TME-mimicking environments	2800:2828	3D TME-mimicking environments	2800:2828	Here we examine how MW and HA content in collagen-HA networks alter structural and mechanical properties to regulate cell migration and matrix remodeling in 3D TME-mimicking environments.
34116226	3	45	from	weight	530:535	arg1	unknown					568:574	unknown	568:574	unknown	568:574	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	3	45	from	weight	530:535	arg1	consequences					490:501	the consequences	486:501	the consequences of changes in HA molecular weight and concentration	486:553	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	10	46	theme	HMW	1588:1590	arg1	gels					1595:1598	HMW HA gels	1588:1598	HMW HA gels	1588:1598	Surprisingly, even though elastic modulus increased with HA molecular weight and concentration, gel compaction assays showed an increased degree of ECM compaction among HMW HA gels at high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%]).
34116226	6	47	used	used	828:831	arg2	we					825:826	we	825:826	we	825:826	In our study, we used vLMW, LMW and HMW HA at different physiologically relevant concentrations, with a particular interest in correlating the mechanical and structural properties to different cell functions.
34116226	13	48	theme	molecular	1910:1918	arg1	weight					1920:1925	HA molecular weight	1907:1925	HA molecular weight	1907:1925	Consequently, changes in HA molecular weight can have relatively large effects on cancer cell behavior.
34116226	5	49	theme	HA	693:694	arg1	weight					706:711	HA molecular weight	693:711	HA molecular weight	693:711	Here we examine the influence of HA molecular weight on biophysical properties that regulate cell migration and extracellular matrix (ECM) remodeling.
34116226	15	50	theme	HA	2108:2109	arg1	Overproduction					2090:2103	Overproduction	2090:2103	Overproduction of HA in the TME	2090:2120	Overproduction of HA in the TME results in poor prognosis and collapse of blood vessels, inhibiting drug delivery.
34116226	3	51	from	concentration	541:553	arg1	unknown					568:574	unknown	568:574	unknown	568:574	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	3	51	from	concentration	541:553	arg1	consequences					490:501	the consequences	486:501	the consequences of changes in HA molecular weight and concentration	486:553	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	10	52	theme	compaction	1571:1580	arg1	degree					1557:1562	an increased degree	1544:1562	an increased degree of ECM compaction among HMW HA gels	1544:1598	Surprisingly, even though elastic modulus increased with HA molecular weight and concentration, gel compaction assays showed an increased degree of ECM compaction among HMW HA gels at high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%]).
34116226	0	53	theme	Cancer	0:5	arg1	migration					12:20	Cancer cell migration	0:20	Cancer cell migration in collagen-hyaluronan composite extracellular matrices.	0:77	Cancer cell migration in collagen-hyaluronan composite extracellular matrices.
34116226	1	54	from	component	104:112	arg1	TME					145:147	TME	145:147	TME	145:147	Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates in cancer growth and invasiveness.
34116226	1	54	from	component	104:112	arg1	microenvironment					127:142	the tumor microenvironment	117:142	the tumor microenvironment (TME)	117:148	Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates in cancer growth and invasiveness.
34116226	16	55	used	used	2230:2233	arg2	Hyaluronidases					2205:2218	Hyaluronidases	2205:2218	Hyaluronidases	2205:2218	Hyaluronidases have been used to enhance drug delivery.
34116226	17	56	theme	cell	2385:2388	arg1	behavior					2390:2397	the TME and cancer cell behavior	2366:2397	the TME and cancer cell behavior	2366:2397	However, they lead to low molecular weight (MW) HA, altering the mechanical and structural properties of the TME and cancer cell behavior.
34116226	3	57	from	changes	506:512	arg1	weight					530:535	HA molecular weight	517:535	HA molecular weight	517:535	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	3	57	from	changes	506:512	arg1	concentration					541:553	concentration	541:553	concentration	541:553	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	10	58	theme	high	1603:1606	arg1	concentrations					1608:1621	high concentrations	1603:1621	high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%])	1603:1654	Surprisingly, even though elastic modulus increased with HA molecular weight and concentration, gel compaction assays showed an increased degree of ECM compaction among HMW HA gels at high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%]).
34116226	7	59	theme	collagen	1072:1079	arg1	diameter					1087:1094	collagen fiber diameter	1072:1094	collagen fiber diameter	1072:1094	The elastic modulus, collagen network pore size and collagen fiber diameter increased with increasing HA concentration.
34116226	9	60	theme	cell	1258:1261	arg1	migration					1263:1271	cell migration	1258:1271	cell migration	1258:1271	Consequently, cell migration decreased with increase in HA concentration due to multiple, long-lived and unproductive protrusions, suggesting the influence of steric factors.
34116226	1	61	theme	key	100:102	arg1	component					104:112	a key component	98:112	a key component in the tumor microenvironment (TME) that participates in cancer growth and invasiveness	98:200	Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates in cancer growth and invasiveness.
34116226	1	61	theme	key	100:102	arg1	Hyaluronan					79:88	Hyaluronan	79:88	Hyaluronan (HA)	79:93	Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates in cancer growth and invasiveness.
34116226	20	62	theme	cell	2760:2763	arg1	migration					2765:2773	cell migration	2760:2773	cell migration	2760:2773	Here we examine how MW and HA content in collagen-HA networks alter structural and mechanical properties to regulate cell migration and matrix remodeling in 3D TME-mimicking environments.
34116226	0	63	theme	collagen-hyaluronan	25:43	arg1	matrices					69:76	collagen-hyaluronan composite extracellular matrices	25:76	collagen-hyaluronan composite extracellular matrices	25:76	Cancer cell migration in collagen-hyaluronan composite extracellular matrices.
34116226	5	64	theme	molecular	696:704	arg1	weight					706:711	HA molecular weight	693:711	HA molecular weight	693:711	Here we examine the influence of HA molecular weight on biophysical properties that regulate cell migration and extracellular matrix (ECM) remodeling.
34116226	12	65	theme	molecular	1864:1872	arg1	weight					1874:1879	high HA molecular weight	1856:1879	high HA molecular weight	1856:1879	HA appears to have the effect of decreasing migration and increasing collagen network contraction, but only at high HA molecular weight.
34116226	2	66	theme	elevated	317:324	arg1	levels					326:331	the elevated levels	313:331	the elevated levels of HA in the TME	313:348	While the molecular weight (MW) dependent properties of HA can cause tumor-promoting and -repressing effects, the elevated levels of HA in the TME impedes drug delivery.
34116226	0	67	theme	extracellular	55:67	arg1	matrices					69:76	collagen-hyaluronan composite extracellular matrices	25:76	collagen-hyaluronan composite extracellular matrices	25:76	Cancer cell migration in collagen-hyaluronan composite extracellular matrices.
34116226	20	68	theme	structural	2711:2720	arg1	properties					2737:2746	structural and mechanical properties	2711:2746	structural and mechanical properties	2711:2746	Here we examine how MW and HA content in collagen-HA networks alter structural and mechanical properties to regulate cell migration and matrix remodeling in 3D TME-mimicking environments.
34116226	19	69	from	behavior	2583:2590	arg1	networks					2633:2640	tumor-mimicking collagen-HA composite networks	2595:2640	tumor-mimicking collagen-HA composite networks	2595:2640	Very little is known about how HA MW affects cancer cell behavior in tumor-mimicking collagen-HA composite networks.
34116226	9	70	theme	HA	1300:1301	arg1	concentration					1303:1315	HA concentration	1300:1315	HA concentration due to multiple, long-lived and unproductive protrusions	1300:1372	Consequently, cell migration decreased with increase in HA concentration due to multiple, long-lived and unproductive protrusions, suggesting the influence of steric factors.
34116226	11	71	contain	had	1722:1724	arg2	stiffness					1734:1742	similar stiffness	1726:1742	similar stiffness	1726:1742	These results were not seen in collagen gels that lacked HA, but had similar stiffness.
34116226	11	71	contain	had	1722:1724	arg1	gels					1697:1700	collagen gels	1688:1700	collagen gels that lacked HA, but had similar stiffness	1688:1742	These results were not seen in collagen gels that lacked HA, but had similar stiffness.
34116226	10	72	theme	molecular	1479:1487	arg1	weight					1489:1494	HA molecular weight	1476:1494	HA molecular weight	1476:1494	Surprisingly, even though elastic modulus increased with HA molecular weight and concentration, gel compaction assays showed an increased degree of ECM compaction among HMW HA gels at high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%]).
34116226	16	73	theme	drug	2246:2249	arg1	delivery					2251:2258	drug delivery	2246:2258	drug delivery	2246:2258	Hyaluronidases have been used to enhance drug delivery.
34116226	9	74	theme	due	1317:1319	arg1	concentration					1303:1315	HA concentration	1300:1315	HA concentration due to multiple, long-lived and unproductive protrusions	1300:1372	Consequently, cell migration decreased with increase in HA concentration due to multiple, long-lived and unproductive protrusions, suggesting the influence of steric factors.
34116226	7	75	theme	collagen	1041:1048	arg1	size					1063:1066	collagen network pore size	1041:1066	collagen network pore size	1041:1066	The elastic modulus, collagen network pore size and collagen fiber diameter increased with increasing HA concentration.
34116226	14	76	theme	microenvironment	2066:2081	arg1	STATEMENT					1986:1994	STATEMENT	1986:1994	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA)	1986:2027	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA) is a critical component of the tumor microenvironment (TME).
34116226	14	76	theme	microenvironment	2066:2081	arg1	component					2043:2051	a critical component	2032:2051	a critical component of the tumor microenvironment (TME)	2032:2087	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA) is a critical component of the tumor microenvironment (TME).
34116226	3	77	theme	HA	451:452	arg1	fragments					438:446	fragments	438:446	fragments of HA	438:452	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	9	78	theme	multiple	1324:1331	arg1	protrusions					1362:1372	multiple, long-lived and unproductive protrusions	1324:1372	multiple, long-lived and unproductive protrusions	1324:1372	Consequently, cell migration decreased with increase in HA concentration due to multiple, long-lived and unproductive protrusions, suggesting the influence of steric factors.
34116226	6	79	theme	different	994:1002	arg1	functions					1009:1017	different cell functions	994:1017	different cell functions	994:1017	In our study, we used vLMW, LMW and HMW HA at different physiologically relevant concentrations, with a particular interest in correlating the mechanical and structural properties to different cell functions.
34116226	17	80	theme	mechanical	2326:2335	arg1	properties					2352:2361	the mechanical and structural properties	2322:2361	the mechanical and structural properties of the TME and cancer cell behavior	2322:2397	However, they lead to low molecular weight (MW) HA, altering the mechanical and structural properties of the TME and cancer cell behavior.
34116226	18	81	theme	cancer	2441:2446	arg1	behavior					2453:2460	cancer cell behavior	2441:2460	cancer cell behavior	2441:2460	Understanding how HA degradation affects cancer cell behavior is critical for uncovering detrimental effects of this therapy.
34116226	9	82	theme	long-lived	1334:1343	arg1	protrusions					1362:1372	multiple, long-lived and unproductive protrusions	1324:1372	multiple, long-lived and unproductive protrusions	1324:1372	Consequently, cell migration decreased with increase in HA concentration due to multiple, long-lived and unproductive protrusions, suggesting the influence of steric factors.
34116226	12	83	theme	high	1856:1859	arg1	weight					1874:1879	high HA molecular weight	1856:1879	high HA molecular weight	1856:1879	HA appears to have the effect of decreasing migration and increasing collagen network contraction, but only at high HA molecular weight.
34116226	20	84	theme	HA	2670:2671	arg1	content					2673:2679	HA content	2670:2679	HA content	2670:2679	Here we examine how MW and HA content in collagen-HA networks alter structural and mechanical properties to regulate cell migration and matrix remodeling in 3D TME-mimicking environments.
34116226	9	85	theme	unproductive	1349:1360	arg1	protrusions					1362:1372	multiple, long-lived and unproductive protrusions	1324:1372	multiple, long-lived and unproductive protrusions	1324:1372	Consequently, cell migration decreased with increase in HA concentration due to multiple, long-lived and unproductive protrusions, suggesting the influence of steric factors.
34116226	7	86	theme	network	1050:1056	arg1	size					1063:1066	collagen network pore size	1041:1066	collagen network pore size	1041:1066	The elastic modulus, collagen network pore size and collagen fiber diameter increased with increasing HA concentration.
34116226	8	87	theme	collagen	1153:1160	arg1	size					1175:1178	the collagen network pore size	1149:1178	the collagen network pore size	1149:1178	Although the collagen network pore size increased, these pores were filled with the bulky HA molecules.
34116226	2	88	theme	-repressing	292:302	arg1	effects					304:310	tumor-promoting and -repressing effects	272:310	tumor-promoting and -repressing effects	272:310	While the molecular weight (MW) dependent properties of HA can cause tumor-promoting and -repressing effects, the elevated levels of HA in the TME impedes drug delivery.
34116226	6	89	theme	different	857:865	arg1	concentrations					892:905	different physiologically relevant concentrations	857:905	different physiologically relevant concentrations	857:905	In our study, we used vLMW, LMW and HMW HA at different physiologically relevant concentrations, with a particular interest in correlating the mechanical and structural properties to different cell functions.
34116226	14	90	dep	STATEMENT	1986:1994	arg1	Hyaluronan					2013:2022	Hyaluronan	2013:2022	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA)	1986:2027	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA) is a critical component of the tumor microenvironment (TME).
34116226	14	90	dep	STATEMENT	1986:1994	arg1	HA					2025:2026	HA	2025:2026	HA	2025:2026	STATEMENT OF SIGNIFICANCE: Hyaluronan (HA) is a critical component of the tumor microenvironment (TME).
34116226	12	91	contain	have	1759:1762	arg2	effect					1768:1773	the effect	1764:1773	the effect of decreasing migration and increasing collagen network contraction	1764:1841	HA appears to have the effect of decreasing migration and increasing collagen network contraction, but only at high HA molecular weight.
34116226	12	91	contain	have	1759:1762	arg1	HA					1745:1746	HA	1745:1746	HA	1745:1746	HA appears to have the effect of decreasing migration and increasing collagen network contraction, but only at high HA molecular weight.
34116226	17	92	theme	low	2283:2285	arg1	MW					2305:2306	MW	2305:2306	MW	2305:2306	However, they lead to low molecular weight (MW) HA, altering the mechanical and structural properties of the TME and cancer cell behavior.
34116226	17	92	theme	low	2283:2285	arg1	weight					2297:2302	low molecular weight	2283:2302	low molecular weight (MW) HA	2283:2310	However, they lead to low molecular weight (MW) HA, altering the mechanical and structural properties of the TME and cancer cell behavior.
34116226	8	93	theme	pore	1170:1173	arg1	size					1175:1178	the collagen network pore size	1149:1178	the collagen network pore size	1149:1178	Although the collagen network pore size increased, these pores were filled with the bulky HA molecules.
34116226	10	94	theme	compaction	1519:1528	arg1	assays					1530:1535	gel compaction assays	1515:1535	gel compaction assays	1515:1535	Surprisingly, even though elastic modulus increased with HA molecular weight and concentration, gel compaction assays showed an increased degree of ECM compaction among HMW HA gels at high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%]).
34116226	11	95	theme	collagen	1688:1695	arg1	gels					1697:1700	collagen gels	1688:1700	collagen gels that lacked HA, but had similar stiffness	1688:1742	These results were not seen in collagen gels that lacked HA, but had similar stiffness.
34116226	2	96	theme	tumor-promoting	272:286	arg1	effects					304:310	tumor-promoting and -repressing effects	272:310	tumor-promoting and -repressing effects	272:310	While the molecular weight (MW) dependent properties of HA can cause tumor-promoting and -repressing effects, the elevated levels of HA in the TME impedes drug delivery.
34116226	5	97	theme	cell	753:756	arg1	migration					758:766	cell migration	753:766	cell migration	753:766	Here we examine the influence of HA molecular weight on biophysical properties that regulate cell migration and extracellular matrix (ECM) remodeling.
34116226	17	98	theme	weight	2297:2302	arg1	HA					2309:2310	low molecular weight (MW) HA	2283:2310	low molecular weight (MW) HA	2283:2310	However, they lead to low molecular weight (MW) HA, altering the mechanical and structural properties of the TME and cancer cell behavior.
34116226	19	99	theme	HA	2557:2558	arg1	MW					2560:2561	HA MW	2557:2561	HA MW	2557:2561	Very little is known about how HA MW affects cancer cell behavior in tumor-mimicking collagen-HA composite networks.
34116226	20	100	theme	3D	2800:2801	arg1	environments					2817:2828	3D TME-mimicking environments	2800:2828	3D TME-mimicking environments	2800:2828	Here we examine how MW and HA content in collagen-HA networks alter structural and mechanical properties to regulate cell migration and matrix remodeling in 3D TME-mimicking environments.
34116226	20	101	theme	mechanical	2726:2735	arg1	properties					2737:2746	structural and mechanical properties	2711:2746	structural and mechanical properties	2711:2746	Here we examine how MW and HA content in collagen-HA networks alter structural and mechanical properties to regulate cell migration and matrix remodeling in 3D TME-mimicking environments.
34116226	17	102	theme	behavior	2390:2397	arg1	properties					2352:2361	the mechanical and structural properties	2322:2361	the mechanical and structural properties of the TME and cancer cell behavior	2322:2397	However, they lead to low molecular weight (MW) HA, altering the mechanical and structural properties of the TME and cancer cell behavior.
34116226	10	103	theme	increased	1547:1555	arg1	degree					1557:1562	an increased degree	1544:1562	an increased degree of ECM compaction among HMW HA gels	1544:1598	Surprisingly, even though elastic modulus increased with HA molecular weight and concentration, gel compaction assays showed an increased degree of ECM compaction among HMW HA gels at high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%]).
34116226	9	104	theme	factors	1410:1416	arg1	influence					1390:1398	the influence	1386:1398	the influence of steric factors	1386:1416	Consequently, cell migration decreased with increase in HA concentration due to multiple, long-lived and unproductive protrusions, suggesting the influence of steric factors.
34116226	12	105	theme	network	1823:1829	arg1	contraction					1831:1841	collagen network contraction	1814:1841	collagen network contraction	1814:1841	HA appears to have the effect of decreasing migration and increasing collagen network contraction, but only at high HA molecular weight.
34116226	4	106	theme	MW-dependent	621:632	arg1	effects					645:651	the MW-dependent biological effects	617:651	the MW-dependent biological effects of HA	617:657	Therefore, it is critical to understand the MW-dependent biological effects of HA.
34116226	15	107	theme	drug	2190:2193	arg1	delivery					2195:2202	drug delivery	2190:2202	drug delivery	2190:2202	Overproduction of HA in the TME results in poor prognosis and collapse of blood vessels, inhibiting drug delivery.
34116226	2	108	theme	dependent	235:243	arg1	properties					245:254	the molecular weight (MW) dependent properties	209:254	the molecular weight (MW) dependent properties of HA	209:260	While the molecular weight (MW) dependent properties of HA can cause tumor-promoting and -repressing effects, the elevated levels of HA in the TME impedes drug delivery.
34116226	0	109	theme	composite	45:53	arg1	matrices					69:76	collagen-hyaluronan composite extracellular matrices	25:76	collagen-hyaluronan composite extracellular matrices	25:76	Cancer cell migration in collagen-hyaluronan composite extracellular matrices.
34116226	18	110	theme	detrimental	2489:2499	arg1	effects					2501:2507	detrimental effects	2489:2507	detrimental effects of this therapy	2489:2523	Understanding how HA degradation affects cancer cell behavior is critical for uncovering detrimental effects of this therapy.
34116226	13	111	theme	cell	1971:1974	arg1	behavior					1976:1983	cancer cell behavior	1964:1983	cancer cell behavior	1964:1983	Consequently, changes in HA molecular weight can have relatively large effects on cancer cell behavior.
34116226	3	112	theme	molecular	520:528	arg1	weight					530:535	HA molecular weight	517:535	HA molecular weight	517:535	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	19	113	theme	cell	2578:2581	arg1	behavior					2583:2590	cancer cell behavior	2571:2590	cancer cell behavior in tumor-mimicking collagen-HA composite networks	2571:2640	Very little is known about how HA MW affects cancer cell behavior in tumor-mimicking collagen-HA composite networks.
34116226	10	114	theme	gel	1515:1517	arg1	assays					1530:1535	gel compaction assays	1515:1535	gel compaction assays	1515:1535	Surprisingly, even though elastic modulus increased with HA molecular weight and concentration, gel compaction assays showed an increased degree of ECM compaction among HMW HA gels at high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%]).
34116226	8	115	theme	bulky	1224:1228	arg1	molecules					1233:1241	the bulky HA molecules	1220:1241	the bulky HA molecules	1220:1241	Although the collagen network pore size increased, these pores were filled with the bulky HA molecules.
34116226	9	116	from	increase	1288:1295	arg1	concentration					1303:1315	HA concentration	1300:1315	HA concentration due to multiple, long-lived and unproductive protrusions	1300:1372	Consequently, cell migration decreased with increase in HA concentration due to multiple, long-lived and unproductive protrusions, suggesting the influence of steric factors.
34116226	18	117	dep	Understanding	2400:2412	arg1	affects					2433:2439	affects	2433:2439	affects cancer cell behavior	2433:2460	Understanding how HA degradation affects cancer cell behavior is critical for uncovering detrimental effects of this therapy.
34116226	17	118	theme	structural	2341:2350	arg1	properties					2352:2361	the mechanical and structural properties	2322:2361	the mechanical and structural properties of the TME and cancer cell behavior	2322:2397	However, they lead to low molecular weight (MW) HA, altering the mechanical and structural properties of the TME and cancer cell behavior.
34116226	13	119	theme	large	1947:1951	arg1	effects					1953:1959	relatively large effects	1936:1959	relatively large effects	1936:1959	Consequently, changes in HA molecular weight can have relatively large effects on cancer cell behavior.
34116226	6	120	theme	relevant	883:890	arg1	concentrations					892:905	different physiologically relevant concentrations	857:905	different physiologically relevant concentrations	857:905	In our study, we used vLMW, LMW and HMW HA at different physiologically relevant concentrations, with a particular interest in correlating the mechanical and structural properties to different cell functions.
34116226	13	121	theme	HA	1907:1908	arg1	weight					1920:1925	HA molecular weight	1907:1925	HA molecular weight	1907:1925	Consequently, changes in HA molecular weight can have relatively large effects on cancer cell behavior.
34116226	17	122	theme	TME	2370:2372	arg1	behavior					2390:2397	the TME and cancer cell behavior	2366:2397	the TME and cancer cell behavior	2366:2397	However, they lead to low molecular weight (MW) HA, altering the mechanical and structural properties of the TME and cancer cell behavior.
34116226	5	123	theme	biophysical	716:726	arg1	properties					728:737	biophysical properties	716:737	biophysical properties that regulate cell migration and extracellular matrix (ECM) remodeling	716:808	Here we examine the influence of HA molecular weight on biophysical properties that regulate cell migration and extracellular matrix (ECM) remodeling.
34116226	6	124	theme	structural	969:978	arg1	properties					980:989	the mechanical and structural properties	950:989	the mechanical and structural properties to different cell functions	950:1017	In our study, we used vLMW, LMW and HMW HA at different physiologically relevant concentrations, with a particular interest in correlating the mechanical and structural properties to different cell functions.
34116226	6	125	from	concentrations	892:905	arg1	LMW					839:841	LMW	839:841	LMW	839:841	In our study, we used vLMW, LMW and HMW HA at different physiologically relevant concentrations, with a particular interest in correlating the mechanical and structural properties to different cell functions.
34116226	6	125	from	concentrations	892:905	arg1	vLMW					833:836	vLMW	833:836	vLMW	833:836	In our study, we used vLMW, LMW and HMW HA at different physiologically relevant concentrations, with a particular interest in correlating the mechanical and structural properties to different cell functions.
34116226	6	125	from	concentrations	892:905	arg1	HMW					847:849	HMW	847:849	HMW	847:849	In our study, we used vLMW, LMW and HMW HA at different physiologically relevant concentrations, with a particular interest in correlating the mechanical and structural properties to different cell functions.
34116226	17	126	theme	cancer	2378:2383	arg1	behavior					2390:2397	the TME and cancer cell behavior	2366:2397	the TME and cancer cell behavior	2366:2397	However, they lead to low molecular weight (MW) HA, altering the mechanical and structural properties of the TME and cancer cell behavior.
34116226	4	127	theme	HA	656:657	arg1	effects					645:651	the MW-dependent biological effects	617:651	the MW-dependent biological effects of HA	617:657	Therefore, it is critical to understand the MW-dependent biological effects of HA.
34116226	3	128	theme	HA	392:393	arg1	way					460:462	a way	458:462	a way to overcome this	458:479	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	3	128	theme	HA	392:393	arg1	degradation					377:387	The degradation	373:387	The degradation	373:387	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	6	129	theme	mechanical	954:963	arg1	properties					980:989	the mechanical and structural properties	950:989	the mechanical and structural properties to different cell functions	950:1017	In our study, we used vLMW, LMW and HMW HA at different physiologically relevant concentrations, with a particular interest in correlating the mechanical and structural properties to different cell functions.
34116226	7	130	theme	pore	1058:1061	arg1	size					1063:1066	collagen network pore size	1041:1066	collagen network pore size	1041:1066	The elastic modulus, collagen network pore size and collagen fiber diameter increased with increasing HA concentration.
34116226	20	131	theme	matrix	2779:2784	arg1	remodeling					2786:2795	matrix remodeling	2779:2795	matrix remodeling	2779:2795	Here we examine how MW and HA content in collagen-HA networks alter structural and mechanical properties to regulate cell migration and matrix remodeling in 3D TME-mimicking environments.
34116226	2	132	theme	drug	358:361	arg1	delivery					363:370	drug delivery	358:370	drug delivery	358:370	While the molecular weight (MW) dependent properties of HA can cause tumor-promoting and -repressing effects, the elevated levels of HA in the TME impedes drug delivery.
34116226	20	133	from	MW	2663:2664	arg1	networks					2696:2703	collagen-HA networks	2684:2703	collagen-HA networks	2684:2703	Here we examine how MW and HA content in collagen-HA networks alter structural and mechanical properties to regulate cell migration and matrix remodeling in 3D TME-mimicking environments.
34116226	10	134	theme	HA	1592:1593	arg1	gels					1595:1598	HMW HA gels	1588:1598	HMW HA gels	1588:1598	Surprisingly, even though elastic modulus increased with HA molecular weight and concentration, gel compaction assays showed an increased degree of ECM compaction among HMW HA gels at high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%]).
34116226	5	135	theme	weight	706:711	arg1	influence					680:688	the influence	676:688	the influence of HA molecular weight on biophysical properties that regulate cell migration and extracellular matrix (ECM) remodeling	676:808	Here we examine the influence of HA molecular weight on biophysical properties that regulate cell migration and extracellular matrix (ECM) remodeling.
34116226	10	136	theme	elastic	1445:1451	arg1	modulus					1453:1459	elastic modulus	1445:1459	elastic modulus	1445:1459	Surprisingly, even though elastic modulus increased with HA molecular weight and concentration, gel compaction assays showed an increased degree of ECM compaction among HMW HA gels at high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%]).
34116226	11	137	theme	similar	1726:1732	arg1	stiffness					1734:1742	similar stiffness	1726:1742	similar stiffness	1726:1742	These results were not seen in collagen gels that lacked HA, but had similar stiffness.
34116226	20	138	from	migration	2765:2773	arg1	environments					2817:2828	3D TME-mimicking environments	2800:2828	3D TME-mimicking environments	2800:2828	Here we examine how MW and HA content in collagen-HA networks alter structural and mechanical properties to regulate cell migration and matrix remodeling in 3D TME-mimicking environments.
34116226	3	139	theme	HA	517:518	arg1	weight					530:535	HA molecular weight	517:535	HA molecular weight	517:535	The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown.
34116226	2	140	theme	HA	336:337	arg1	levels					326:331	the elevated levels	313:331	the elevated levels of HA in the TME	313:348	While the molecular weight (MW) dependent properties of HA can cause tumor-promoting and -repressing effects, the elevated levels of HA in the TME impedes drug delivery.
34116226	15	141	theme	blood	2164:2168	arg1	vessels					2170:2176	blood vessels	2164:2176	blood vessels	2164:2176	Overproduction of HA in the TME results in poor prognosis and collapse of blood vessels, inhibiting drug delivery.
34116226	9	142	theme	steric	1403:1408	arg1	factors					1410:1416	steric factors	1403:1416	steric factors	1403:1416	Consequently, cell migration decreased with increase in HA concentration due to multiple, long-lived and unproductive protrusions, suggesting the influence of steric factors.
34116226	10	143	theme	HA	1476:1477	arg1	weight					1489:1494	HA molecular weight	1476:1494	HA molecular weight	1476:1494	Surprisingly, even though elastic modulus increased with HA molecular weight and concentration, gel compaction assays showed an increased degree of ECM compaction among HMW HA gels at high concentrations (2 and 4 mg mL-1 [0.2 and 0.4%]).
34116226	5	144	dep	migration	758:766	arg1	remodeling					799:808	remodeling	799:808	remodeling	799:808	Here we examine the influence of HA molecular weight on biophysical properties that regulate cell migration and extracellular matrix (ECM) remodeling.
34116226	0	145	theme	cell	7:10	arg1	migration					12:20	Cancer cell migration	0:20	Cancer cell migration in collagen-hyaluronan composite extracellular matrices.	0:77	Cancer cell migration in collagen-hyaluronan composite extracellular matrices.
32570969	0	0	theme	Analytical	72:81	arg1	Strategy					83:90	A New Analytical Strategy	66:90	A New Analytical Strategy	66:90	Multiscale Structure of Starches Grafted with Hydrophobic Groups: A New Analytical Strategy.
32570969	4	1	theme	Flight	1012:1017	arg1	Mass					1033:1036	Flight Secondary Ion Mass	1012:1036	Flight Secondary Ion Mass	1012:1036	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	2	2	theme	hydroxyl	353:360	arg1	groups					362:367	the free hydroxyl groups	344:367	the free hydroxyl groups	344:367	In order to optimize its functional properties for bioplastics applications chemical groups need to be introduced on the free hydroxyl groups in a controlled manner, so an understanding of the resulting structure-properties relationships is therefore essential.
32570969	5	3	theme	specific	1078:1085	arg1	ways					1087:1090	specific ways	1078:1090	specific ways of chain breakage due to modification	1078:1128	Molar mass decrease and specific ways of chain breakage due to modification were pointed out and are correlated to the amylose content.
32570969	0	4	theme	New	68:70	arg1	Strategy					83:90	A New Analytical Strategy	66:90	A New Analytical Strategy	66:90	Multiscale Structure of Starches Grafted with Hydrophobic Groups: A New Analytical Strategy.
32570969	2	5	theme	free	348:351	arg1	groups					362:367	the free hydroxyl groups	344:367	the free hydroxyl groups	344:367	In order to optimize its functional properties for bioplastics applications chemical groups need to be introduced on the free hydroxyl groups in a controlled manner, so an understanding of the resulting structure-properties relationships is therefore essential.
32570969	8	6	theme	materials	1559:1567	arg1	properties					1517:1526	the properties	1513:1526	the properties of such insoluble starch-based materials	1513:1567	This strategy, then applied to characterize etherified starches, opens the way to correlate the structure to the properties of such insoluble starch-based materials.
32570969	5	7	theme	chain	1095:1099	arg1	breakage					1101:1108	chain breakage	1095:1108	chain breakage due to modification	1095:1128	Molar mass decrease and specific ways of chain breakage due to modification were pointed out and are correlated to the amylose content.
32570969	3	8	theme	experimental	672:683	arg1	strategies					685:694	experimental strategies	672:694	experimental strategies	672:694	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	4	9	theme	Multiangle	925:934	arg1	Scattering					948:957	Multiangle Laser Light Scattering	925:957	Multiangle Laser Light Scattering	925:957	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	9	theme	Multiangle	925:934	arg1	Time					1004:1007	Time	1004:1007	Time of Flight Secondary Ion Mass	1004:1036	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	9	theme	Multiangle	925:934	arg1	Raman					994:998	Raman	994:998	Raman	994:998	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	9	theme	Multiangle	925:934	arg1	Resonance					977:985	Nuclear Magnetic Resonance	960:985	Nuclear Magnetic Resonance (NMR)	960:991	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	5	10	theme	mass	1060:1063	arg1	decrease					1065:1072	Molar mass decrease	1054:1072	Molar mass decrease	1054:1072	Molar mass decrease and specific ways of chain breakage due to modification were pointed out and are correlated to the amylose content.
32570969	4	11	dep	Resonance	977:985	arg1	spectroscopies					1038:1051	spectroscopies	1038:1051	spectroscopies	1038:1051	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	1	12	contain	has	152:154	arg1	glucopolymer					138:149	an abundant and low-cost plant-based glucopolymer	101:149	an abundant and low-cost plant-based glucopolymer	101:149	Starch, an abundant and low-cost plant-based glucopolymer, has great potential to replace carbon-based polymers in various materials.
32570969	1	12	contain	has	152:154	arg1	Starch					93:98	Starch	93:98	Starch	93:98	Starch, an abundant and low-cost plant-based glucopolymer, has great potential to replace carbon-based polymers in various materials.
32570969	1	12	contain	has	152:154	arg2	potential					162:170	great potential	156:170	great potential to replace carbon-based polymers in various materials	156:224	Starch, an abundant and low-cost plant-based glucopolymer, has great potential to replace carbon-based polymers in various materials.
32570969	2	13	theme	bioplastics	278:288	arg1	applications					290:301	bioplastics applications	278:301	bioplastics applications	278:301	In order to optimize its functional properties for bioplastics applications chemical groups need to be introduced on the free hydroxyl groups in a controlled manner, so an understanding of the resulting structure-properties relationships is therefore essential.
32570969	6	14	theme	solid-state	1234:1244	arg1	NMR					1246:1248	solid-state NMR	1234:1248	solid-state NMR	1234:1248	The amorphous structuration was revealed by solid-state NMR.
32570969	0	15	theme	Multiscale	0:9	arg1	Structure					11:19	Multiscale Structure	0:19	Multiscale Structure of Starches Grafted with Hydrophobic Groups	0:63	Multiscale Structure of Starches Grafted with Hydrophobic Groups: A New Analytical Strategy.
32570969	7	16	from	solvents	1394:1401	arg1	insoluble					1373:1381	insoluble	1373:1381	insoluble	1373:1381	This original broad analytical approach allowed for the first time a large characterization of highly-acetylated starches insoluble in aqueous solvents.
32570969	2	17	dep	need	319:322	arg1	optimize					239:246	optimize	239:246	to optimize its functional properties for bioplastics applications	236:301	In order to optimize its functional properties for bioplastics applications chemical groups need to be introduced on the free hydroxyl groups in a controlled manner, so an understanding of the resulting structure-properties relationships is therefore essential.
32570969	4	18	theme	Flow	879:882	arg1	Fractionation					895:907	Asymmetrical Flow Field Flow Fractionation	866:907	Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies	866:1051	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	7	19	theme	highly-acetylated	1346:1362	arg1	starches					1364:1371	highly-acetylated starches	1346:1371	highly-acetylated starches insoluble in aqueous solvents	1346:1401	This original broad analytical approach allowed for the first time a large characterization of highly-acetylated starches insoluble in aqueous solvents.
32570969	6	20	theme	amorphous	1194:1202	arg1	structuration					1204:1216	The amorphous structuration	1190:1216	The amorphous structuration	1190:1216	The amorphous structuration was revealed by solid-state NMR.
32570969	7	21	theme	starches	1364:1371	arg1	characterization					1326:1341	a large characterization	1318:1341	a large characterization of highly-acetylated starches insoluble in aqueous solvents	1318:1401	This original broad analytical approach allowed for the first time a large characterization of highly-acetylated starches insoluble in aqueous solvents.
32570969	1	22	theme	great	156:160	arg1	potential					162:170	great potential	156:170	great potential to replace carbon-based polymers in various materials	156:224	Starch, an abundant and low-cost plant-based glucopolymer, has great potential to replace carbon-based polymers in various materials.
32570969	4	23	theme	Mass	1033:1036	arg1	Scattering					948:957	Multiangle Laser Light Scattering	925:957	Multiangle Laser Light Scattering	925:957	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	23	theme	Mass	1033:1036	arg1	Time					1004:1007	Time	1004:1007	Time of Flight Secondary Ion Mass	1004:1036	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	23	theme	Mass	1033:1036	arg1	NMR					988:990	NMR	988:990	NMR	988:990	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	23	theme	Mass	1033:1036	arg1	Raman					994:998	Raman	994:998	Raman	994:998	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	23	theme	Mass	1033:1036	arg1	Resonance					977:985	Nuclear Magnetic Resonance	960:985	Nuclear Magnetic Resonance (NMR)	960:991	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	3	24	theme	methodologies	700:712	arg1	combination					657:667	an original combination	645:667	an original combination of experimental strategies and methodologies	645:712	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	4	25	theme	Ion	1029:1031	arg1	Mass					1033:1036	Flight Secondary Ion Mass	1012:1036	Flight Secondary Ion Mass	1012:1036	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	0	26	dep	Strategy	83:90	arg1	Structure					11:19	Multiscale Structure	0:19	Multiscale Structure of Starches Grafted with Hydrophobic Groups	0:63	Multiscale Structure of Starches Grafted with Hydrophobic Groups: A New Analytical Strategy.
32570969	8	27	theme	etherified	1448:1457	arg1	starches					1459:1466	etherified starches	1448:1466	etherified starches	1448:1466	This strategy, then applied to characterize etherified starches, opens the way to correlate the structure to the properties of such insoluble starch-based materials.
32570969	7	28	theme	aqueous	1386:1392	arg1	solvents					1394:1401	aqueous solvents	1386:1401	aqueous solvents	1386:1401	This original broad analytical approach allowed for the first time a large characterization of highly-acetylated starches insoluble in aqueous solvents.
32570969	2	29	theme	relationships	451:463	arg1	essential					478:486	essential	478:486	essential	478:486	In order to optimize its functional properties for bioplastics applications chemical groups need to be introduced on the free hydroxyl groups in a controlled manner, so an understanding of the resulting structure-properties relationships is therefore essential.
32570969	2	29	theme	relationships	451:463	arg1	understanding					399:411	an understanding	396:411	an understanding of the resulting structure-properties relationships	396:463	In order to optimize its functional properties for bioplastics applications chemical groups need to be introduced on the free hydroxyl groups in a controlled manner, so an understanding of the resulting structure-properties relationships is therefore essential.
32570969	4	30	theme	Flow	890:893	arg1	Fractionation					895:907	Asymmetrical Flow Field Flow Fractionation	866:907	Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies	866:1051	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	31	dep	structure	729:737	arg1	repartition					756:766	repartition	756:766	repartition	756:766	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	7	32	theme	first	1307:1311	arg1	time					1313:1316	the first time	1303:1316	the first time	1303:1316	This original broad analytical approach allowed for the first time a large characterization of highly-acetylated starches insoluble in aqueous solvents.
32570969	2	33	theme	controlled	374:383	arg1	manner					385:390	a controlled manner	372:390	a controlled manner	372:390	In order to optimize its functional properties for bioplastics applications chemical groups need to be introduced on the free hydroxyl groups in a controlled manner, so an understanding of the resulting structure-properties relationships is therefore essential.
32570969	2	34	theme	structure-properties	430:449	arg1	relationships					451:463	the resulting structure-properties relationships	416:463	the resulting structure-properties relationships	416:463	In order to optimize its functional properties for bioplastics applications chemical groups need to be introduced on the free hydroxyl groups in a controlled manner, so an understanding of the resulting structure-properties relationships is therefore essential.
32570969	4	35	theme	Field	884:888	arg1	Fractionation					895:907	Asymmetrical Flow Field Flow Fractionation	866:907	Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies	866:1051	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	7	36	theme	insoluble	1373:1381	arg1	starches					1364:1371	highly-acetylated starches	1346:1371	highly-acetylated starches insoluble in aqueous solvents	1346:1401	This original broad analytical approach allowed for the first time a large characterization of highly-acetylated starches insoluble in aqueous solvents.
32570969	0	37	theme	Starches	24:31	arg1	Structure					11:19	Multiscale Structure	0:19	Multiscale Structure of Starches Grafted with Hydrophobic Groups	0:63	Multiscale Structure of Starches Grafted with Hydrophobic Groups: A New Analytical Strategy.
32570969	4	38	theme	Magnetic	968:975	arg1	Scattering					948:957	Multiangle Laser Light Scattering	925:957	Multiangle Laser Light Scattering	925:957	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	38	theme	Magnetic	968:975	arg1	NMR					988:990	NMR	988:990	NMR	988:990	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	38	theme	Magnetic	968:975	arg1	Resonance					977:985	Nuclear Magnetic Resonance	960:985	Nuclear Magnetic Resonance (NMR)	960:991	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	3	39	theme	highly-acetylated	555:571	arg1	starches					627:634	highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches	555:634	highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches	555:634	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	8	40	theme	starch-based	1546:1557	arg1	materials					1559:1567	such insoluble starch-based materials	1531:1567	such insoluble starch-based materials	1531:1567	This strategy, then applied to characterize etherified starches, opens the way to correlate the structure to the properties of such insoluble starch-based materials.
32570969	1	41	theme	carbon-based	183:194	arg1	polymers					196:203	carbon-based polymers	183:203	carbon-based polymers	183:203	Starch, an abundant and low-cost plant-based glucopolymer, has great potential to replace carbon-based polymers in various materials.
32570969	4	42	theme	Nuclear	960:966	arg1	Scattering					948:957	Multiangle Laser Light Scattering	925:957	Multiangle Laser Light Scattering	925:957	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	42	theme	Nuclear	960:966	arg1	NMR					988:990	NMR	988:990	NMR	988:990	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	42	theme	Nuclear	960:966	arg1	Resonance					977:985	Nuclear Magnetic Resonance	960:985	Nuclear Magnetic Resonance (NMR)	960:991	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	3	43	theme	starches	627:634	arg1	structure					542:550	the multiscale structure	527:550	the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches	527:634	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	2	44	theme	chemical	303:310	arg1	groups					312:317	chemical groups	303:317	chemical groups	303:317	In order to optimize its functional properties for bioplastics applications chemical groups need to be introduced on the free hydroxyl groups in a controlled manner, so an understanding of the resulting structure-properties relationships is therefore essential.
32570969	3	45	dep	highly-acetylated	555:571	arg1	degree					574:579	degree	574:579	degree of substitution	574:595	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	3	46	theme	work	509:512	arg1	purpose					493:499	The purpose	489:499	The purpose of this work	489:512	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	5	47	theme	breakage	1101:1108	arg1	ways					1087:1090	specific ways	1078:1090	specific ways of chain breakage due to modification	1078:1128	Molar mass decrease and specific ways of chain breakage due to modification were pointed out and are correlated to the amylose content.
32570969	5	47	theme	breakage	1101:1108	arg1	decrease					1065:1072	Molar mass decrease	1054:1072	Molar mass decrease	1054:1072	Molar mass decrease and specific ways of chain breakage due to modification were pointed out and are correlated to the amylose content.
32570969	4	48	theme	specific	838:845	arg1	analysis					847:854	specific analysis	838:854	specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies	838:1051	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	7	49	theme	large	1320:1324	arg1	characterization					1326:1341	a large characterization	1318:1341	a large characterization of highly-acetylated starches insoluble in aqueous solvents	1318:1401	This original broad analytical approach allowed for the first time a large characterization of highly-acetylated starches insoluble in aqueous solvents.
32570969	4	50	theme	Secondary	1019:1027	arg1	Mass					1033:1036	Flight Secondary Ion Mass	1012:1036	Flight Secondary Ion Mass	1012:1036	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	2	51	theme	resulting	420:428	arg1	relationships					451:463	the resulting structure-properties relationships	416:463	the resulting structure-properties relationships	416:463	In order to optimize its functional properties for bioplastics applications chemical groups need to be introduced on the free hydroxyl groups in a controlled manner, so an understanding of the resulting structure-properties relationships is therefore essential.
32570969	1	52	theme	various	208:214	arg1	materials					216:224	various materials	208:224	various materials	208:224	Starch, an abundant and low-cost plant-based glucopolymer, has great potential to replace carbon-based polymers in various materials.
32570969	5	53	theme	amylose	1173:1179	arg1	content					1181:1187	the amylose content	1169:1187	the amylose content	1169:1187	Molar mass decrease and specific ways of chain breakage due to modification were pointed out and are correlated to the amylose content.
32570969	4	54	theme	Light	942:946	arg1	Scattering					948:957	Multiangle Laser Light Scattering	925:957	Multiangle Laser Light Scattering	925:957	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	54	theme	Light	942:946	arg1	Time					1004:1007	Time	1004:1007	Time of Flight Secondary Ion Mass	1004:1036	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	54	theme	Light	942:946	arg1	Raman					994:998	Raman	994:998	Raman	994:998	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	54	theme	Light	942:946	arg1	Resonance					977:985	Nuclear Magnetic Resonance	960:985	Nuclear Magnetic Resonance (NMR)	960:991	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	3	55	theme	etherified	616:625	arg1	starches					627:634	highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches	555:634	highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches	555:634	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	3	56	theme	substitution	584:595	arg1	degree					574:579	degree	574:579	degree of substitution	574:595	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	0	57	theme	Hydrophobic	46:56	arg1	Groups					58:63	Hydrophobic Groups	46:63	Hydrophobic Groups	46:63	Multiscale Structure of Starches Grafted with Hydrophobic Groups: A New Analytical Strategy.
32570969	4	58	theme	Laser	936:940	arg1	Scattering					948:957	Multiangle Laser Light Scattering	925:957	Multiangle Laser Light Scattering	925:957	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	58	theme	Laser	936:940	arg1	Time					1004:1007	Time	1004:1007	Time of Flight Secondary Ion Mass	1004:1036	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	58	theme	Laser	936:940	arg1	Raman					994:998	Raman	994:998	Raman	994:998	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	4	58	theme	Laser	936:940	arg1	Resonance					977:985	Nuclear Magnetic Resonance	960:985	Nuclear Magnetic Resonance (NMR)	960:991	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	3	59	theme	original	648:655	arg1	combination					657:667	an original combination	645:667	an original combination of experimental strategies and methodologies	645:712	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	4	60	theme	Asymmetrical	866:877	arg1	Fractionation					895:907	Asymmetrical Flow Field Flow Fractionation	866:907	Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies	866:1051	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	1	61	theme	abundant	104:111	arg1	glucopolymer					138:149	an abundant and low-cost plant-based glucopolymer	101:149	an abundant and low-cost plant-based glucopolymer	101:149	Starch, an abundant and low-cost plant-based glucopolymer, has great potential to replace carbon-based polymers in various materials.
32570969	1	61	theme	abundant	104:111	arg1	Starch					93:98	Starch	93:98	Starch	93:98	Starch, an abundant and low-cost plant-based glucopolymer, has great potential to replace carbon-based polymers in various materials.
32570969	5	62	theme	Molar	1054:1058	arg1	decrease					1065:1072	Molar mass decrease	1054:1072	Molar mass decrease	1054:1072	Molar mass decrease and specific ways of chain breakage due to modification were pointed out and are correlated to the amylose content.
32570969	4	63	theme	sample	804:809	arg1	strategies					823:832	new sample preparation strategies	800:832	new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies	800:1051	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	2	64	theme	functional	252:261	arg1	properties					263:272	its functional properties	248:272	its functional properties	248:272	In order to optimize its functional properties for bioplastics applications chemical groups need to be introduced on the free hydroxyl groups in a controlled manner, so an understanding of the resulting structure-properties relationships is therefore essential.
32570969	3	65	theme	<	602:602	arg1	≤					607:607	0.4 < DS ≤ 3	598:609	0.4 < DS ≤ 3	598:609	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	3	66	dep	degree	574:579	arg1	≤					607:607	0.4 < DS ≤ 3	598:609	0.4 < DS ≤ 3	598:609	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	3	67	theme	multiscale	531:540	arg1	structure					542:550	the multiscale structure	527:550	the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches	527:634	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	8	68	theme	such	1531:1534	arg1	materials					1559:1567	such insoluble starch-based materials	1531:1567	such insoluble starch-based materials	1531:1567	This strategy, then applied to characterize etherified starches, opens the way to correlate the structure to the properties of such insoluble starch-based materials.
32570969	4	69	theme	new	800:802	arg1	strategies					823:832	new sample preparation strategies	800:832	new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies	800:1051	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	8	70	theme	insoluble	1536:1544	arg1	materials					1559:1567	such insoluble starch-based materials	1531:1567	such insoluble starch-based materials	1531:1567	This strategy, then applied to characterize etherified starches, opens the way to correlate the structure to the properties of such insoluble starch-based materials.
32570969	1	71	theme	low-cost	117:124	arg1	glucopolymer					138:149	an abundant and low-cost plant-based glucopolymer	101:149	an abundant and low-cost plant-based glucopolymer	101:149	Starch, an abundant and low-cost plant-based glucopolymer, has great potential to replace carbon-based polymers in various materials.
32570969	1	71	theme	low-cost	117:124	arg1	Starch					93:98	Starch	93:98	Starch	93:98	Starch, an abundant and low-cost plant-based glucopolymer, has great potential to replace carbon-based polymers in various materials.
32570969	4	72	theme	molecular	719:727	arg1	structure					729:737	The molecular structure	715:737	The molecular structure	715:737	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	7	73	theme	original	1256:1263	arg1	approach					1282:1289	This original broad analytical approach	1251:1289	This original broad analytical approach	1251:1289	This original broad analytical approach allowed for the first time a large characterization of highly-acetylated starches insoluble in aqueous solvents.
32570969	3	74	theme	DS	604:605	arg1	≤					607:607	0.4 < DS ≤ 3	598:609	0.4 < DS ≤ 3	598:609	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	7	75	from	insoluble	1373:1381	arg1	solvents					1394:1401	aqueous solvents	1386:1401	aqueous solvents	1386:1401	This original broad analytical approach allowed for the first time a large characterization of highly-acetylated starches insoluble in aqueous solvents.
32570969	1	76	theme	plant-based	126:136	arg1	glucopolymer					138:149	an abundant and low-cost plant-based glucopolymer	101:149	an abundant and low-cost plant-based glucopolymer	101:149	Starch, an abundant and low-cost plant-based glucopolymer, has great potential to replace carbon-based polymers in various materials.
32570969	1	76	theme	plant-based	126:136	arg1	Starch					93:98	Starch	93:98	Starch	93:98	Starch, an abundant and low-cost plant-based glucopolymer, has great potential to replace carbon-based polymers in various materials.
32570969	7	77	theme	broad	1265:1269	arg1	approach					1282:1289	This original broad analytical approach	1251:1289	This original broad analytical approach	1251:1289	This original broad analytical approach allowed for the first time a large characterization of highly-acetylated starches insoluble in aqueous solvents.
32570969	3	78	theme	strategies	685:694	arg1	combination					657:667	an original combination	645:667	an original combination of experimental strategies and methodologies	645:712	The purpose of this work was to study the multiscale structure of highly-acetylated (degree of substitution, 0.4 < DS ≤ 3) and etherified starches by using an original combination of experimental strategies and methodologies.
32570969	4	79	theme	preparation	811:821	arg1	strategies					823:832	new sample preparation strategies	800:832	new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies	800:1051	The molecular structure and substituents repartition were investigated by developing new sample preparation strategies for specific analysis including Asymmetrical Flow Field Flow Fractionation associated with Multiangle Laser Light Scattering, Nuclear Magnetic Resonance (NMR), Raman and Time of Flight Secondary Ion Mass spectroscopies.
32570969	7	80	theme	analytical	1271:1280	arg1	approach					1282:1289	This original broad analytical approach	1251:1289	This original broad analytical approach	1251:1289	This original broad analytical approach allowed for the first time a large characterization of highly-acetylated starches insoluble in aqueous solvents.
33229151	0	0	theme	grape	87:91	arg1	seeds					93:97	grape seeds	87:97	grape seeds	87:97	Gentianose: Purification and structural determination of an unknown oligosaccharide in grape seeds.
33229151	0	1	from	Purification	12:23	arg1	seeds					93:97	grape seeds	87:97	grape seeds	87:97	Gentianose: Purification and structural determination of an unknown oligosaccharide in grape seeds.
33229151	8	2	theme	Grape	1089:1093	arg1	seeds					1095:1099	Grape seeds	1089:1099	Grape seeds	1089:1099	Grape seeds are wine industry by-products and the obtained results suggest the importance of their recovery.
33229151	8	2	theme	Grape	1089:1093	arg1	by-products					1119:1129	wine industry by-products	1105:1129	wine industry by-products	1105:1129	Grape seeds are wine industry by-products and the obtained results suggest the importance of their recovery.
33229151	1	3	theme	grape	147:151	arg1	pomace					153:158	grape pomace	147:158	grape pomace	147:158	Grape seeds are among the main constituents of grape pomace, ranging between 20% and 30% of the wet matrix; however, their oligosaccharide composition has not been studied.
33229151	7	4	theme	product	949:955	arg1	elucidation					919:929	The structure elucidation	905:929	The structure elucidation of the acetylated product	905:955	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	1	5	theme	pomace	153:158	arg1	constituents					131:142	the main constituents	122:142	the main constituents of grape pomace	122:158	Grape seeds are among the main constituents of grape pomace, ranging between 20% and 30% of the wet matrix; however, their oligosaccharide composition has not been studied.
33229151	4	6	theme	Chemical	567:574	arg1	characterization					576:591	Chemical characterization	567:591	Chemical characterization of the combined fractions	567:617	Chemical characterization of the combined fractions was performed by Magnetic Resonance Spectroscopy and Gas Chromatography-Mass Spectrometry analyses.
33229151	5	7	theme	abundant	761:768	arg1	fractions					751:759	two fractions	747:759	two fractions abundant in sucrose and glucose	747:791	The separation process gave two fractions abundant in sucrose and glucose.
33229151	4	8	theme	Gas	672:674	arg1	Spectrometry					696:707	Gas Chromatography-Mass Spectrometry	672:707	Gas Chromatography-Mass Spectrometry	672:707	Chemical characterization of the combined fractions was performed by Magnetic Resonance Spectroscopy and Gas Chromatography-Mass Spectrometry analyses.
33229151	6	9	contain	containing	811:820	arg1	fraction					802:809	A third fraction	794:809	A third fraction containing trisaccharides	794:835	A third fraction containing trisaccharides was acetylated allowing the purification of the main trisaccharide.
33229151	6	9	contain	containing	811:820	arg2	trisaccharides					822:835	trisaccharides	822:835	trisaccharides	822:835	A third fraction containing trisaccharides was acetylated allowing the purification of the main trisaccharide.
33229151	7	10	theme	predominant	1000:1010	arg1	reserve					1025:1031	a predominant carbohydrate reserve	998:1031	a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea	998:1086	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	7	10	theme	predominant	1000:1010	arg1	gentianose					986:995	gentianose	986:995	gentianose	986:995	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	7	11	theme	structure	909:917	arg1	elucidation					919:929	The structure elucidation	905:929	The structure elucidation of the acetylated product	905:955	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	8	12	theme	industry	1110:1117	arg1	seeds					1095:1099	Grape seeds	1089:1099	Grape seeds	1089:1099	Grape seeds are wine industry by-products and the obtained results suggest the importance of their recovery.
33229151	8	12	theme	industry	1110:1117	arg1	by-products					1119:1129	wine industry by-products	1105:1129	wine industry by-products	1105:1129	Grape seeds are wine industry by-products and the obtained results suggest the importance of their recovery.
33229151	7	13	theme	carbohydrate	1012:1023	arg1	reserve					1025:1031	a predominant carbohydrate reserve	998:1031	a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea	998:1086	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	7	13	theme	carbohydrate	1012:1023	arg1	gentianose					986:995	gentianose	986:995	gentianose	986:995	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	2	14	theme	oligosaccharides	358:373	arg1	purification					298:309	the purification	294:309	the purification	294:309	This paper describes the purification and the identification of low molecular weight oligosaccharides contained in an EtOH/water extract of grape seeds.
33229151	2	14	theme	oligosaccharides	358:373	arg1	identification					319:332	the identification	315:332	the identification	315:332	This paper describes the purification and the identification of low molecular weight oligosaccharides contained in an EtOH/water extract of grape seeds.
33229151	0	15	from	determination	40:52	arg1	seeds					93:97	grape seeds	87:97	grape seeds	87:97	Gentianose: Purification and structural determination of an unknown oligosaccharide in grape seeds.
33229151	8	16	theme	wine	1105:1108	arg1	seeds					1095:1099	Grape seeds	1089:1099	Grape seeds	1089:1099	Grape seeds are wine industry by-products and the obtained results suggest the importance of their recovery.
33229151	8	16	theme	wine	1105:1108	arg1	by-products					1119:1129	wine industry by-products	1105:1129	wine industry by-products	1105:1129	Grape seeds are wine industry by-products and the obtained results suggest the importance of their recovery.
33229151	4	17	theme	Magnetic	636:643	arg1	Spectroscopy					655:666	Magnetic Resonance Spectroscopy	636:666	Magnetic Resonance Spectroscopy	636:666	Chemical characterization of the combined fractions was performed by Magnetic Resonance Spectroscopy and Gas Chromatography-Mass Spectrometry analyses.
33229151	2	18	theme	weight	351:356	arg1	oligosaccharides					358:373	low molecular weight oligosaccharides	337:373	low molecular weight oligosaccharides contained in an EtOH/water extract of grape seeds	337:423	This paper describes the purification and the identification of low molecular weight oligosaccharides contained in an EtOH/water extract of grape seeds.
33229151	2	19	theme	seeds	419:423	arg1	extract					402:408	an EtOH/water extract	388:408	an EtOH/water extract of grape seeds	388:423	This paper describes the purification and the identification of low molecular weight oligosaccharides contained in an EtOH/water extract of grape seeds.
33229151	2	20	theme	molecular	341:349	arg1	weight					351:356	low molecular weight	337:356	low molecular weight oligosaccharides contained in an EtOH/water extract of grape seeds	337:423	This paper describes the purification and the identification of low molecular weight oligosaccharides contained in an EtOH/water extract of grape seeds.
33229151	2	21	theme	grape	413:417	arg1	seeds					419:423	grape seeds	413:423	grape seeds	413:423	This paper describes the purification and the identification of low molecular weight oligosaccharides contained in an EtOH/water extract of grape seeds.
33229151	1	22	theme	oligosaccharide	223:237	arg1	composition					239:249	their oligosaccharide composition	217:249	their oligosaccharide composition	217:249	Grape seeds are among the main constituents of grape pomace, ranging between 20% and 30% of the wet matrix; however, their oligosaccharide composition has not been studied.
33229151	2	23	theme	low	337:339	arg1	weight					351:356	low molecular weight	337:356	low molecular weight oligosaccharides contained in an EtOH/water extract of grape seeds	337:423	This paper describes the purification and the identification of low molecular weight oligosaccharides contained in an EtOH/water extract of grape seeds.
33229151	8	24	theme	obtained	1139:1146	arg1	results					1148:1154	the obtained results	1135:1154	the obtained results	1135:1154	Grape seeds are wine industry by-products and the obtained results suggest the importance of their recovery.
33229151	1	25	theme	Grape	100:104	arg1	seeds					106:110	Grape seeds	100:110	Grape seeds	100:110	Grape seeds are among the main constituents of grape pomace, ranging between 20% and 30% of the wet matrix; however, their oligosaccharide composition has not been studied.
33229151	2	26	theme	EtOH/water	391:400	arg1	extract					402:408	an EtOH/water extract	388:408	an EtOH/water extract of grape seeds	388:423	This paper describes the purification and the identification of low molecular weight oligosaccharides contained in an EtOH/water extract of grape seeds.
33229151	5	27	from	sucrose	773:779	arg1	abundant					761:768	abundant	761:768	abundant	761:768	The separation process gave two fractions abundant in sucrose and glucose.
33229151	3	28	theme	molecular	548:556	arg1	weights					558:564	molecular weights	548:564	molecular weights	548:564	A sequential two-step purification by size exclusion chromatography was carried out to fractionate compounds according to molecular weights.
33229151	3	29	theme	two-step	439:446	arg1	purification					448:459	A sequential two-step purification	426:459	A sequential two-step purification by size exclusion chromatography	426:492	A sequential two-step purification by size exclusion chromatography was carried out to fractionate compounds according to molecular weights.
33229151	7	30	located	found	1033:1037	arg1	roots					1054:1058	the storage roots	1042:1058	the storage roots of perennial Gentiana lutea	1042:1086	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	7	30	located	found	1033:1037	arg2	reserve					1025:1031	a predominant carbohydrate reserve	998:1031	a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea	998:1086	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	7	30	located	found	1033:1037	arg2	gentianose					986:995	gentianose	986:995	gentianose	986:995	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	4	31	dep	Spectroscopy	655:666	arg1	analyses					709:716	analyses	709:716	analyses	709:716	Chemical characterization of the combined fractions was performed by Magnetic Resonance Spectroscopy and Gas Chromatography-Mass Spectrometry analyses.
33229151	4	32	theme	Chromatography-Mass	676:694	arg1	Spectrometry					696:707	Gas Chromatography-Mass Spectrometry	672:707	Gas Chromatography-Mass Spectrometry	672:707	Chemical characterization of the combined fractions was performed by Magnetic Resonance Spectroscopy and Gas Chromatography-Mass Spectrometry analyses.
33229151	0	33	theme	structural	29:38	arg1	determination					40:52	structural determination	29:52	structural determination	29:52	Gentianose: Purification and structural determination of an unknown oligosaccharide in grape seeds.
33229151	5	34	from	abundant	761:768	arg1	sucrose					773:779	sucrose	773:779	sucrose	773:779	The separation process gave two fractions abundant in sucrose and glucose.
33229151	5	34	from	abundant	761:768	arg1	glucose					785:791	glucose	785:791	glucose	785:791	The separation process gave two fractions abundant in sucrose and glucose.
33229151	6	35	theme	third	796:800	arg1	fraction					802:809	A third fraction	794:809	A third fraction containing trisaccharides	794:835	A third fraction containing trisaccharides was acetylated allowing the purification of the main trisaccharide.
33229151	4	36	theme	Resonance	645:653	arg1	Spectroscopy					655:666	Magnetic Resonance Spectroscopy	636:666	Magnetic Resonance Spectroscopy	636:666	Chemical characterization of the combined fractions was performed by Magnetic Resonance Spectroscopy and Gas Chromatography-Mass Spectrometry analyses.
33229151	8	37	theme	recovery	1188:1195	arg1	importance					1168:1177	the importance	1164:1177	the importance of their recovery	1164:1195	Grape seeds are wine industry by-products and the obtained results suggest the importance of their recovery.
33229151	7	38	theme	lutea	1082:1086	arg1	roots					1054:1058	the storage roots	1042:1058	the storage roots of perennial Gentiana lutea	1042:1086	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	3	39	theme	size	464:467	arg1	chromatography					479:492	size exclusion chromatography	464:492	size exclusion chromatography	464:492	A sequential two-step purification by size exclusion chromatography was carried out to fractionate compounds according to molecular weights.
33229151	6	40	theme	trisaccharide	890:902	arg1	purification					865:876	the purification	861:876	the purification of the main trisaccharide	861:902	A third fraction containing trisaccharides was acetylated allowing the purification of the main trisaccharide.
33229151	3	41	theme	exclusion	469:477	arg1	chromatography					479:492	size exclusion chromatography	464:492	size exclusion chromatography	464:492	A sequential two-step purification by size exclusion chromatography was carried out to fractionate compounds according to molecular weights.
33229151	6	42	theme	main	885:888	arg1	trisaccharide					890:902	the main trisaccharide	881:902	the main trisaccharide	881:902	A third fraction containing trisaccharides was acetylated allowing the purification of the main trisaccharide.
33229151	7	43	theme	perennial	1063:1071	arg1	lutea					1082:1086	perennial Gentiana lutea	1063:1086	perennial Gentiana lutea	1063:1086	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	4	44	theme	fractions	609:617	arg1	characterization					576:591	Chemical characterization	567:591	Chemical characterization of the combined fractions	567:617	Chemical characterization of the combined fractions was performed by Magnetic Resonance Spectroscopy and Gas Chromatography-Mass Spectrometry analyses.
33229151	5	45	theme	separation	723:732	arg1	process					734:740	The separation process	719:740	The separation process	719:740	The separation process gave two fractions abundant in sucrose and glucose.
33229151	5	46	from	glucose	785:791	arg1	abundant					761:768	abundant	761:768	abundant	761:768	The separation process gave two fractions abundant in sucrose and glucose.
33229151	7	47	theme	Gentiana	1073:1080	arg1	lutea					1082:1086	perennial Gentiana lutea	1063:1086	perennial Gentiana lutea	1063:1086	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	7	48	theme	storage	1046:1052	arg1	roots					1054:1058	the storage roots	1042:1058	the storage roots of perennial Gentiana lutea	1042:1086	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	1	49	theme	main	126:129	arg1	constituents					131:142	the main constituents	122:142	the main constituents of grape pomace	122:158	Grape seeds are among the main constituents of grape pomace, ranging between 20% and 30% of the wet matrix; however, their oligosaccharide composition has not been studied.
33229151	4	50	theme	combined	600:607	arg1	fractions					609:617	the combined fractions	596:617	the combined fractions	596:617	Chemical characterization of the combined fractions was performed by Magnetic Resonance Spectroscopy and Gas Chromatography-Mass Spectrometry analyses.
33229151	0	51	theme	oligosaccharide	68:82	arg1	Purification					12:23	Purification	12:23	Purification	12:23	Gentianose: Purification and structural determination of an unknown oligosaccharide in grape seeds.
33229151	0	51	theme	oligosaccharide	68:82	arg1	determination					40:52	structural determination	29:52	structural determination	29:52	Gentianose: Purification and structural determination of an unknown oligosaccharide in grape seeds.
33229151	3	52	theme	sequential	428:437	arg1	purification					448:459	A sequential two-step purification	426:459	A sequential two-step purification by size exclusion chromatography	426:492	A sequential two-step purification by size exclusion chromatography was carried out to fractionate compounds according to molecular weights.
33229151	1	53	theme	wet	196:198	arg1	matrix					200:205	the wet matrix	192:205	the wet matrix	192:205	Grape seeds are among the main constituents of grape pomace, ranging between 20% and 30% of the wet matrix; however, their oligosaccharide composition has not been studied.
33229151	0	54	theme	unknown	60:66	arg1	oligosaccharide					68:82	an unknown oligosaccharide	57:82	an unknown oligosaccharide	57:82	Gentianose: Purification and structural determination of an unknown oligosaccharide in grape seeds.
33229151	0	55	dep	Gentianose	0:9	arg1	Purification					12:23	Purification	12:23	Purification	12:23	Gentianose: Purification and structural determination of an unknown oligosaccharide in grape seeds.
33229151	0	55	dep	Gentianose	0:9	arg1	determination					40:52	structural determination	29:52	structural determination	29:52	Gentianose: Purification and structural determination of an unknown oligosaccharide in grape seeds.
33229151	7	56	theme	acetylated	938:947	arg1	product					949:955	the acetylated product	934:955	the acetylated product	934:955	The structure elucidation of the acetylated product made it possible to identify gentianose, a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea.
33229151	1	57	theme	matrix	200:205	arg1	matrix					200:205	the wet matrix	192:205	the wet matrix	192:205	Grape seeds are among the main constituents of grape pomace, ranging between 20% and 30% of the wet matrix; however, their oligosaccharide composition has not been studied.
33229151	1	57	theme	matrix	200:205	arg1	%					179:179	20%	177:179	20%	177:179	Grape seeds are among the main constituents of grape pomace, ranging between 20% and 30% of the wet matrix; however, their oligosaccharide composition has not been studied.
33229151	1	57	theme	matrix	200:205	arg1	%					187:187	30%	185:187	30%	185:187	Grape seeds are among the main constituents of grape pomace, ranging between 20% and 30% of the wet matrix; however, their oligosaccharide composition has not been studied.
34893273	0	0	theme	sodium	108:113	arg1	removal					72:78	the removal	68:78	the removal of water-soluble diclofenac sodium	68:113	Synthesis of glutaraldehyde-modified silica/chitosan composites for the removal of water-soluble diclofenac sodium.
34893273	7	1	theme	high	963:966	arg1	affinity					968:975	a high affinity	961:975	a high affinity between the adsorbents and diclofenac sodium	961:1020	Therefore, it can be assumed that the process is predominantly chemical and exothermic, with a high affinity between the adsorbents and diclofenac sodium.
34893273	1	2	theme	various	180:186	arg1	types					188:192	various types	180:192	various types of contaminants, such as pharmaceutical products	180:241	Composite materials are effective adsorbents for the removal of various types of contaminants, such as pharmaceutical products.
34893273	0	3	theme	diclofenac	97:106	arg1	sodium					108:113	water-soluble diclofenac sodium	83:113	water-soluble diclofenac sodium	83:113	Synthesis of glutaraldehyde-modified silica/chitosan composites for the removal of water-soluble diclofenac sodium.
34893273	8	4	theme	bonds	1139:1143	arg1	predominance					1114:1125	the predominance	1110:1125	the predominance of covalent bonds with the self-polymerized glutaraldehyde	1110:1184	The adsorption mechanisms were investigated to better understand the interactions, and the predominance of covalent bonds with the self-polymerized glutaraldehyde was verified.
34893273	1	5	theme	types	188:192	arg1	removal					169:175	the removal	165:175	the removal of various types of contaminants, such as pharmaceutical products	165:241	Composite materials are effective adsorbents for the removal of various types of contaminants, such as pharmaceutical products.
34893273	7	6	dep	adsorbents	989:998	arg1	the					985:987	the	985:987	the	985:987	Therefore, it can be assumed that the process is predominantly chemical and exothermic, with a high affinity between the adsorbents and diclofenac sodium.
34893273	8	7	theme	adsorption	1027:1036	arg1	mechanisms					1038:1047	The adsorption mechanisms	1023:1047	The adsorption mechanisms	1023:1047	The adsorption mechanisms were investigated to better understand the interactions, and the predominance of covalent bonds with the self-polymerized glutaraldehyde was verified.
34893273	6	8	theme	maximum	824:830	arg1	237.8 mg/g					856:865	237.8 mg/g	856:865	237.8 mg/g	856:865	The equilibrium and kinetic data were well fit by the Liu and Elovich models, respectively, and the maximum adsorption capacity was 237.8 mg/g.
34893273	6	8	theme	maximum	824:830	arg1	capacity					843:850	the maximum adsorption capacity	820:850	the maximum adsorption capacity	820:850	The equilibrium and kinetic data were well fit by the Liu and Elovich models, respectively, and the maximum adsorption capacity was 237.8 mg/g.
34893273	7	9	theme	diclofenac	1004:1013	arg1	sodium					1015:1020	diclofenac sodium	1004:1020	diclofenac sodium	1004:1020	Therefore, it can be assumed that the process is predominantly chemical and exothermic, with a high affinity between the adsorbents and diclofenac sodium.
34893273	3	10	theme	adsorbent	368:376	arg1	development					341:351	the development	337:351	the development of a promising adsorbent	337:376	This study presents the development of a promising adsorbent: silica/chitosan modified with different proportions of glutaraldehyde, which involves the D-glucosamine units from chitosan.
34893273	2	11	theme	adsorption	296:305	arg1	capacity					307:314	a good adsorption capacity	289:314	a good adsorption capacity	289:314	However, they require improvement to achieve a good adsorption capacity.
34893273	5	12	theme	glutaraldehyde	695:708	arg1	crosslinking					710:721	glutaraldehyde crosslinking	695:721	glutaraldehyde crosslinking	695:721	The adsorption data showed that the diclofenac adsorption efficiency increased with increasing degree of glutaraldehyde crosslinking.
34893273	2	13	theme	good	291:294	arg1	capacity					307:314	a good adsorption capacity	289:314	a good adsorption capacity	289:314	However, they require improvement to achieve a good adsorption capacity.
34893273	1	14	theme	contaminants	197:208	arg1	types					188:192	various types	180:192	various types of contaminants, such as pharmaceutical products	180:241	Composite materials are effective adsorbents for the removal of various types of contaminants, such as pharmaceutical products.
34893273	5	15	theme	crosslinking	710:721	arg1	degree					685:690	degree	685:690	degree of glutaraldehyde crosslinking	685:721	The adsorption data showed that the diclofenac adsorption efficiency increased with increasing degree of glutaraldehyde crosslinking.
34893273	5	16	theme	diclofenac	626:635	arg1	efficiency					648:657	the diclofenac adsorption efficiency	622:657	the diclofenac adsorption efficiency	622:657	The adsorption data showed that the diclofenac adsorption efficiency increased with increasing degree of glutaraldehyde crosslinking.
34893273	8	17	theme	covalent	1130:1137	arg1	bonds					1139:1143	covalent bonds	1130:1143	covalent bonds	1130:1143	The adsorption mechanisms were investigated to better understand the interactions, and the predominance of covalent bonds with the self-polymerized glutaraldehyde was verified.
34893273	5	18	theme	adsorption	637:646	arg1	efficiency					648:657	the diclofenac adsorption efficiency	622:657	the diclofenac adsorption efficiency	622:657	The adsorption data showed that the diclofenac adsorption efficiency increased with increasing degree of glutaraldehyde crosslinking.
34893273	1	19	theme	Composite	116:124	arg1	materials					126:134	Composite materials	116:134	Composite materials	116:134	Composite materials are effective adsorbents for the removal of various types of contaminants, such as pharmaceutical products.
34893273	1	19	theme	Composite	116:124	arg1	adsorbents					150:159	effective adsorbents	140:159	effective adsorbents for the removal of various types of contaminants, such as pharmaceutical products	140:241	Composite materials are effective adsorbents for the removal of various types of contaminants, such as pharmaceutical products.
34893273	3	20	theme	D-glucosamine	469:481	arg1	units					483:487	the D-glucosamine units	465:487	the D-glucosamine units from chitosan	465:501	This study presents the development of a promising adsorbent: silica/chitosan modified with different proportions of glutaraldehyde, which involves the D-glucosamine units from chitosan.
34893273	0	21	theme	silica/chitosan	37:51	arg1	composites					53:62	glutaraldehyde-modified silica/chitosan composites	13:62	glutaraldehyde-modified silica/chitosan composites	13:62	Synthesis of glutaraldehyde-modified silica/chitosan composites for the removal of water-soluble diclofenac sodium.
34893273	6	22	theme	adsorption	832:841	arg1	237.8 mg/g					856:865	237.8 mg/g	856:865	237.8 mg/g	856:865	The equilibrium and kinetic data were well fit by the Liu and Elovich models, respectively, and the maximum adsorption capacity was 237.8 mg/g.
34893273	6	22	theme	adsorption	832:841	arg1	capacity					843:850	the maximum adsorption capacity	820:850	the maximum adsorption capacity	820:850	The equilibrium and kinetic data were well fit by the Liu and Elovich models, respectively, and the maximum adsorption capacity was 237.8 mg/g.
34893273	3	23	theme	different	409:417	arg1	proportions					419:429	different proportions	409:429	different proportions of glutaraldehyde, which involves the D-glucosamine units from chitosan	409:501	This study presents the development of a promising adsorbent: silica/chitosan modified with different proportions of glutaraldehyde, which involves the D-glucosamine units from chitosan.
34893273	1	24	theme	pharmaceutical	219:232	arg1	products					234:241	pharmaceutical products	219:241	pharmaceutical products	219:241	Composite materials are effective adsorbents for the removal of various types of contaminants, such as pharmaceutical products.
34893273	8	25	with	predominance	1114:1125	arg1	glutaraldehyde					1171:1184	the self-polymerized glutaraldehyde	1150:1184	the self-polymerized glutaraldehyde	1150:1184	The adsorption mechanisms were investigated to better understand the interactions, and the predominance of covalent bonds with the self-polymerized glutaraldehyde was verified.
34893273	0	26	theme	composites	53:62	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of glutaraldehyde-modified silica/chitosan composites for the removal of water-soluble diclofenac sodium.	0:114	Synthesis of glutaraldehyde-modified silica/chitosan composites for the removal of water-soluble diclofenac sodium.
34893273	8	27	theme	self-polymerized	1154:1169	arg1	glutaraldehyde					1171:1184	the self-polymerized glutaraldehyde	1150:1184	the self-polymerized glutaraldehyde	1150:1184	The adsorption mechanisms were investigated to better understand the interactions, and the predominance of covalent bonds with the self-polymerized glutaraldehyde was verified.
34893273	4	28	theme	developed	508:516	arg1	materials					518:526	The developed materials	504:526	The developed materials	504:526	The developed materials were evaluated for their ability to remove diclofenac sodium.
34893273	3	29	from	chitosan	494:501	arg1	units					483:487	the D-glucosamine units	465:487	the D-glucosamine units from chitosan	465:501	This study presents the development of a promising adsorbent: silica/chitosan modified with different proportions of glutaraldehyde, which involves the D-glucosamine units from chitosan.
34893273	3	30	theme	glutaraldehyde	434:447	arg1	proportions					419:429	different proportions	409:429	different proportions of glutaraldehyde, which involves the D-glucosamine units from chitosan	409:501	This study presents the development of a promising adsorbent: silica/chitosan modified with different proportions of glutaraldehyde, which involves the D-glucosamine units from chitosan.
34893273	4	31	theme	diclofenac	571:580	arg1	sodium					582:587	diclofenac sodium	571:587	diclofenac sodium	571:587	The developed materials were evaluated for their ability to remove diclofenac sodium.
34893273	1	32	theme	effective	140:148	arg1	materials					126:134	Composite materials	116:134	Composite materials	116:134	Composite materials are effective adsorbents for the removal of various types of contaminants, such as pharmaceutical products.
34893273	1	32	theme	effective	140:148	arg1	adsorbents					150:159	effective adsorbents	140:159	effective adsorbents for the removal of various types of contaminants, such as pharmaceutical products	140:241	Composite materials are effective adsorbents for the removal of various types of contaminants, such as pharmaceutical products.
34893273	6	33	theme	kinetic	744:750	arg1	data					752:755	The equilibrium and kinetic data	724:755	data	752:755	The equilibrium and kinetic data were well fit by the Liu and Elovich models, respectively, and the maximum adsorption capacity was 237.8 mg/g.
34893273	6	33	theme	kinetic	744:750	arg1	fit					767:769	fit	767:769	fit	767:769	The equilibrium and kinetic data were well fit by the Liu and Elovich models, respectively, and the maximum adsorption capacity was 237.8 mg/g.
34893273	6	34	dep	Liu	778:780	arg1	the					774:776	the	774:776	the	774:776	The equilibrium and kinetic data were well fit by the Liu and Elovich models, respectively, and the maximum adsorption capacity was 237.8 mg/g.
34893273	6	34	dep	Liu	778:780	arg1	models					794:799	models	794:799	models	794:799	The equilibrium and kinetic data were well fit by the Liu and Elovich models, respectively, and the maximum adsorption capacity was 237.8 mg/g.
34893273	5	35	theme	adsorption	594:603	arg1	data					605:608	The adsorption data	590:608	The adsorption data	590:608	The adsorption data showed that the diclofenac adsorption efficiency increased with increasing degree of glutaraldehyde crosslinking.
34893273	6	36	theme	equilibrium	728:738	arg1	data					752:755	The equilibrium and kinetic data	724:755	data	752:755	The equilibrium and kinetic data were well fit by the Liu and Elovich models, respectively, and the maximum adsorption capacity was 237.8 mg/g.
34893273	6	36	theme	equilibrium	728:738	arg1	fit					767:769	fit	767:769	fit	767:769	The equilibrium and kinetic data were well fit by the Liu and Elovich models, respectively, and the maximum adsorption capacity was 237.8 mg/g.
34893273	0	37	theme	water-soluble	83:95	arg1	sodium					108:113	water-soluble diclofenac sodium	83:113	water-soluble diclofenac sodium	83:113	Synthesis of glutaraldehyde-modified silica/chitosan composites for the removal of water-soluble diclofenac sodium.
34893273	7	38	with	chemical	931:938	arg1	affinity					968:975	a high affinity	961:975	a high affinity between the adsorbents and diclofenac sodium	961:1020	Therefore, it can be assumed that the process is predominantly chemical and exothermic, with a high affinity between the adsorbents and diclofenac sodium.
34893273	0	39	theme	glutaraldehyde-modified	13:35	arg1	composites					53:62	glutaraldehyde-modified silica/chitosan composites	13:62	glutaraldehyde-modified silica/chitosan composites	13:62	Synthesis of glutaraldehyde-modified silica/chitosan composites for the removal of water-soluble diclofenac sodium.
33929729	5	0	theme	fractions	1017:1025	arg1	concentration					981:993	the concentration	977:993	the concentration of individual albumin fractions	977:1025	As for albumins, although their overall concentration had increased as KI increased, changes in the concentration of individual albumin fractions was more complex.
33929729	2	1	theme	enzymatic	510:518	arg1	breakdown					520:528	the enzymatic breakdown	506:528	(ii) the enzymatic breakdown of starch and arabinoxylans during malting	501:571	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	8	2	theme	malt	1390:1393	arg1	values					1398:1403	malt KI values	1390:1403	malt KI values between 39.5% and 42.7%	1390:1427	At malt KI values between 39.5% and 42.7%, the enzymatic activity was at its highest, the degradation of starch was adequate and stable, and the concentration of water-soluble arabinoxylans was optimal.
33929729	9	3	theme	KI	1592:1593	arg1	value					1595:1599	A KI value	1590:1599	A KI value of about 39.5% to 42.7%	1590:1623	A KI value of about 39.5% to 42.7% was therefore considered optimal for the production of wheat malts with superior quality attributes.
33929729	9	4	theme	malts	1686:1690	arg1	production					1666:1675	the production	1662:1675	the production of wheat malts with superior quality attributes	1662:1723	A KI value of about 39.5% to 42.7% was therefore considered optimal for the production of wheat malts with superior quality attributes.
33929729	2	5	theme	glutenins	466:474	arg1	KI					396:397	KI	396:397	KI	396:397	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	2	5	theme	glutenins	466:474	arg1	characterization					411:426	the (i) characterization	403:426	the (i) characterization	403:426	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	1	6	dep	composition	232:242	arg1	degradation					287:297	degradation	287:297	degradation	287:297	Kolbach index (KI) is an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting.
33929729	4	7	theme	higher	763:768	arg1	values					773:778	higher KI values	763:778	higher KI values	763:778	The higher Mw globulins (36.6 to 70.8 kDa) were also increasingly degraded at higher KI values, but the concentration of smaller globulin fractions (14.9 to 35.0 kDa) had increased significantly.
33929729	10	8	theme	fundamental	1876:1886	arg1	parameters					1864:1873	the malting and brewing parameters	1840:1873	the malting and brewing parameters	1840:1873	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	4	9	theme	KI	770:771	arg1	values					773:778	higher KI values	763:778	higher KI values	763:778	The higher Mw globulins (36.6 to 70.8 kDa) were also increasingly degraded at higher KI values, but the concentration of smaller globulin fractions (14.9 to 35.0 kDa) had increased significantly.
33929729	2	10	theme	gliadins	452:459	arg1	KI					396:397	KI	396:397	KI	396:397	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	2	10	theme	gliadins	452:459	arg1	characterization					411:426	the (i) characterization	403:426	the (i) characterization	403:426	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	9	11	dep	%	1614:1614	arg1	to					1616:1617	to	1616:1617	to	1616:1617	A KI value of about 39.5% to 42.7% was therefore considered optimal for the production of wheat malts with superior quality attributes.
33929729	6	12	theme	albumin	1117:1123	arg1	proteins					1125:1132	some new albumin proteins	1108:1132	some new albumin proteins	1108:1132	While there were significant increases in the concentration of some new albumin proteins (43.8 and 84.4 kDa), the concentration of some albumins decreased (21.1 to 64.3 kDa), and some fractions had completely disappeared (28.8 and 64.3 kDa).
33929729	9	13	theme	superior	1697:1704	arg1	attributes					1714:1723	superior quality attributes	1697:1723	superior quality attributes	1697:1723	A KI value of about 39.5% to 42.7% was therefore considered optimal for the production of wheat malts with superior quality attributes.
33929729	1	14	theme	protein	214:220	arg1	composition					232:242	protein molecular composition	214:242	protein molecular composition	214:242	Kolbach index (KI) is an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting.
33929729	3	15	theme	KI	595:596	arg1	values					598:603	malt KI values	590:603	malt KI values	590:603	As malt KI values increased, all fractions of glutenins and gliadins were extensively hydrolyzed.
33929729	10	16	from	study	1772:1776	arg1	valuable					1786:1793	valuable	1786:1793	valuable	1786:1793	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	10	16	from	study	1772:1776	arg1	findings					1753:1760	The findings	1749:1760	The findings from this study	1749:1776	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	9	17	theme	quality	1706:1712	arg1	attributes					1714:1723	superior quality attributes	1697:1723	superior quality attributes	1697:1723	A KI value of about 39.5% to 42.7% was therefore considered optimal for the production of wheat malts with superior quality attributes.
33929729	1	18	theme	molecular	222:230	arg1	composition					232:242	protein molecular composition	214:242	protein molecular composition	214:242	Kolbach index (KI) is an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting.
33929729	2	19	theme	globulins	441:449	arg1	KI					396:397	KI	396:397	KI	396:397	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	2	19	theme	globulins	441:449	arg1	characterization					411:426	the (i) characterization	403:426	the (i) characterization	403:426	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	3	20	theme	glutenins	633:641	arg1	fractions					620:628	all fractions	616:628	all fractions of glutenins and gliadins	616:654	As malt KI values increased, all fractions of glutenins and gliadins were extensively hydrolyzed.
33929729	2	21	theme	arabinoxylans	544:556	arg1	hydrolysis					486:495	their hydrolysis	480:495	their hydrolysis	480:495	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	2	21	theme	arabinoxylans	544:556	arg1	breakdown					520:528	the enzymatic breakdown	506:528	(ii) the enzymatic breakdown of starch and arabinoxylans during malting	501:571	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	4	22	theme	higher	689:694	arg1	70.8 kDa					718:725	70.8 kDa	718:725	70.8 kDa	718:725	The higher Mw globulins (36.6 to 70.8 kDa) were also increasingly degraded at higher KI values, but the concentration of smaller globulin fractions (14.9 to 35.0 kDa) had increased significantly.
33929729	4	22	theme	higher	689:694	arg1	globulins					699:707	The higher Mw globulins	685:707	The higher Mw globulins (36.6 to 70.8 kDa)	685:726	The higher Mw globulins (36.6 to 70.8 kDa) were also increasingly degraded at higher KI values, but the concentration of smaller globulin fractions (14.9 to 35.0 kDa) had increased significantly.
33929729	10	23	theme	high-quality	1910:1921	arg1	malts					1929:1933	high-quality wheat malts	1910:1933	high-quality wheat malts	1910:1933	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	4	24	theme	smaller	806:812	arg1	35.0 kDa					842:849	35.0 kDa	842:849	35.0 kDa	842:849	The higher Mw globulins (36.6 to 70.8 kDa) were also increasingly degraded at higher KI values, but the concentration of smaller globulin fractions (14.9 to 35.0 kDa) had increased significantly.
33929729	4	24	theme	smaller	806:812	arg1	fractions					823:831	smaller globulin fractions	806:831	smaller globulin fractions (14.9 to 35.0 kDa)	806:850	The higher Mw globulins (36.6 to 70.8 kDa) were also increasingly degraded at higher KI values, but the concentration of smaller globulin fractions (14.9 to 35.0 kDa) had increased significantly.
33929729	0	25	theme	macromolecules	90:103	arg1	index					25:29	the index	21:29	the index of protein modification (Kolbach index)	21:69	Relationship between the index of protein modification (Kolbach index) and degradation of macromolecules in wheat malt.
33929729	0	25	theme	macromolecules	90:103	arg1	index					64:68	index	64:68	index	64:68	Relationship between the index of protein modification (Kolbach index) and degradation of macromolecules in wheat malt.
33929729	0	25	theme	macromolecules	90:103	arg1	degradation					75:85	degradation	75:85	degradation of macromolecules in wheat malt	75:117	Relationship between the index of protein modification (Kolbach index) and degradation of macromolecules in wheat malt.
33929729	8	26	theme	KI	1395:1396	arg1	values					1398:1403	malt KI values	1390:1403	malt KI values between 39.5% and 42.7%	1390:1427	At malt KI values between 39.5% and 42.7%, the enzymatic activity was at its highest, the degradation of starch was adequate and stable, and the concentration of water-soluble arabinoxylans was optimal.
33929729	2	27	theme	starch	533:538	arg1	hydrolysis					486:495	their hydrolysis	480:495	their hydrolysis	480:495	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	2	27	theme	starch	533:538	arg1	breakdown					520:528	the enzymatic breakdown	506:528	(ii) the enzymatic breakdown of starch and arabinoxylans during malting	501:571	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	10	28	theme	beer	1798:1801	arg1	companies					1803:1811	beer companies	1798:1811	beer companies	1798:1811	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	2	29	dep	breakdown	520:528	arg1	ii					502:503	ii	502:503	ii	502:503	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	5	30	theme	individual	998:1007	arg1	fractions					1017:1025	individual albumin fractions	998:1025	individual albumin fractions	998:1025	As for albumins, although their overall concentration had increased as KI increased, changes in the concentration of individual albumin fractions was more complex.
33929729	6	31	from	increases	1074:1082	arg1	concentration					1091:1103	the concentration	1087:1103	the concentration of some new albumin proteins	1087:1132	While there were significant increases in the concentration of some new albumin proteins (43.8 and 84.4 kDa), the concentration of some albumins decreased (21.1 to 64.3 kDa), and some fractions had completely disappeared (28.8 and 64.3 kDa).
33929729	1	32	theme	important	145:153	arg1	index					155:159	an important index	142:159	an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting	142:318	Kolbach index (KI) is an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting.
33929729	1	32	theme	important	145:153	arg1	index					128:132	Kolbach index	120:132	Kolbach index (KI)	120:137	Kolbach index (KI) is an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting.
33929729	1	33	theme	wheat	306:310	arg1	malting					312:318	wheat malting	306:318	wheat malting	306:318	Kolbach index (KI) is an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting.
33929729	7	34	theme	higher	1369:1374	arg1	values					1379:1384	higher KI values	1369:1384	higher KI values	1369:1384	Following mashing, the hydrophobicity of the worts had decreased significantly at higher KI values.
33929729	8	35	theme	water-soluble	1549:1561	arg1	arabinoxylans					1563:1575	water-soluble arabinoxylans	1549:1575	water-soluble arabinoxylans	1549:1575	At malt KI values between 39.5% and 42.7%, the enzymatic activity was at its highest, the degradation of starch was adequate and stable, and the concentration of water-soluble arabinoxylans was optimal.
33929729	9	36	theme	42.7	1619:1622	arg1	%					1614:1614	%	1614:1614	%	1614:1614	A KI value of about 39.5% to 42.7% was therefore considered optimal for the production of wheat malts with superior quality attributes.
33929729	10	37	dep	APPLICATION	1736:1746	arg1	valuable					1786:1793	valuable	1786:1793	valuable	1786:1793	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	10	37	dep	APPLICATION	1736:1746	arg1	findings					1753:1760	The findings	1749:1760	The findings from this study	1749:1776	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	4	38	theme	globulin	814:821	arg1	35.0 kDa					842:849	35.0 kDa	842:849	35.0 kDa	842:849	The higher Mw globulins (36.6 to 70.8 kDa) were also increasingly degraded at higher KI values, but the concentration of smaller globulin fractions (14.9 to 35.0 kDa) had increased significantly.
33929729	4	38	theme	globulin	814:821	arg1	fractions					823:831	smaller globulin fractions	806:831	smaller globulin fractions (14.9 to 35.0 kDa)	806:850	The higher Mw globulins (36.6 to 70.8 kDa) were also increasingly degraded at higher KI values, but the concentration of smaller globulin fractions (14.9 to 35.0 kDa) had increased significantly.
33929729	6	39	theme	new	1113:1115	arg1	proteins					1125:1132	some new albumin proteins	1108:1132	some new albumin proteins	1108:1132	While there were significant increases in the concentration of some new albumin proteins (43.8 and 84.4 kDa), the concentration of some albumins decreased (21.1 to 64.3 kDa), and some fractions had completely disappeared (28.8 and 64.3 kDa).
33929729	10	40	theme	wheat	1939:1943	arg1	beer					1945:1948	wheat beer	1939:1948	wheat beer	1939:1948	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	6	41	dep	decreased	1190:1198	arg1	64.3 kDa					1276:1283	64.3 kDa	1276:1283	64.3 kDa	1276:1283	While there were significant increases in the concentration of some new albumin proteins (43.8 and 84.4 kDa), the concentration of some albumins decreased (21.1 to 64.3 kDa), and some fractions had completely disappeared (28.8 and 64.3 kDa).
33929729	6	41	dep	decreased	1190:1198	arg1	28.8					1267:1270	28.8	1267:1270	28.8	1267:1270	While there were significant increases in the concentration of some new albumin proteins (43.8 and 84.4 kDa), the concentration of some albumins decreased (21.1 to 64.3 kDa), and some fractions had completely disappeared (28.8 and 64.3 kDa).
33929729	6	41	dep	decreased	1190:1198	arg1	64.3 kDa					1209:1216	64.3 kDa	1209:1216	64.3 kDa	1209:1216	While there were significant increases in the concentration of some new albumin proteins (43.8 and 84.4 kDa), the concentration of some albumins decreased (21.1 to 64.3 kDa), and some fractions had completely disappeared (28.8 and 64.3 kDa).
33929729	1	42	theme	enzyme	245:250	arg1	activity					252:259	enzyme activity	245:259	enzyme activity	245:259	Kolbach index (KI) is an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting.
33929729	0	43	theme	wheat	108:112	arg1	malt					114:117	wheat malt	108:117	wheat malt	108:117	Relationship between the index of protein modification (Kolbach index) and degradation of macromolecules in wheat malt.
33929729	10	44	theme	malts	1929:1933	arg1	production					1896:1905	the production	1892:1905	the production of high-quality wheat malts and wheat beer	1892:1948	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	6	45	dep	were	1057:1060	arg1	84.4 kDa					1144:1151	84.4 kDa	1144:1151	84.4 kDa	1144:1151	While there were significant increases in the concentration of some new albumin proteins (43.8 and 84.4 kDa), the concentration of some albumins decreased (21.1 to 64.3 kDa), and some fractions had completely disappeared (28.8 and 64.3 kDa).
33929729	6	45	dep	were	1057:1060	arg1	43.8					1135:1138	43.8	1135:1138	43.8	1135:1138	While there were significant increases in the concentration of some new albumin proteins (43.8 and 84.4 kDa), the concentration of some albumins decreased (21.1 to 64.3 kDa), and some fractions had completely disappeared (28.8 and 64.3 kDa).
33929729	0	46	theme	protein	34:40	arg1	modification					42:53	protein modification	34:53	protein modification	34:53	Relationship between the index of protein modification (Kolbach index) and degradation of macromolecules in wheat malt.
33929729	3	47	theme	gliadins	647:654	arg1	fractions					620:628	all fractions	616:628	all fractions of glutenins and gliadins	616:654	As malt KI values increased, all fractions of glutenins and gliadins were extensively hydrolyzed.
33929729	10	48	theme	wheat	1923:1927	arg1	malts					1929:1933	high-quality wheat malts	1910:1933	high-quality wheat malts	1910:1933	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	8	49	theme	arabinoxylans	1563:1575	arg1	optimal					1581:1587	optimal	1581:1587	optimal	1581:1587	At malt KI values between 39.5% and 42.7%, the enzymatic activity was at its highest, the degradation of starch was adequate and stable, and the concentration of water-soluble arabinoxylans was optimal.
33929729	8	49	theme	arabinoxylans	1563:1575	arg1	concentration					1532:1544	the concentration	1528:1544	the concentration of water-soluble arabinoxylans	1528:1575	At malt KI values between 39.5% and 42.7%, the enzymatic activity was at its highest, the degradation of starch was adequate and stable, and the concentration of water-soluble arabinoxylans was optimal.
33929729	4	50	dep	70.8 kDa	718:725	arg1	to					715:716	to	715:716	to	715:716	The higher Mw globulins (36.6 to 70.8 kDa) were also increasingly degraded at higher KI values, but the concentration of smaller globulin fractions (14.9 to 35.0 kDa) had increased significantly.
33929729	7	51	theme	worts	1332:1336	arg1	hydrophobicity					1310:1323	the hydrophobicity	1306:1323	the hydrophobicity of the worts	1306:1336	Following mashing, the hydrophobicity of the worts had decreased significantly at higher KI values.
33929729	4	52	theme	fractions	823:831	arg1	concentration					789:801	the concentration	785:801	the concentration of smaller globulin fractions (14.9 to 35.0 kDa)	785:850	The higher Mw globulins (36.6 to 70.8 kDa) were also increasingly degraded at higher KI values, but the concentration of smaller globulin fractions (14.9 to 35.0 kDa) had increased significantly.
33929729	10	53	theme	brewing	1856:1862	arg1	parameters					1864:1873	the malting and brewing parameters	1840:1873	the malting and brewing parameters	1840:1873	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	6	54	theme	proteins	1125:1132	arg1	concentration					1091:1103	the concentration	1087:1103	the concentration of some new albumin proteins	1087:1132	While there were significant increases in the concentration of some new albumin proteins (43.8 and 84.4 kDa), the concentration of some albumins decreased (21.1 to 64.3 kDa), and some fractions had completely disappeared (28.8 and 64.3 kDa).
33929729	10	55	theme	malting	1844:1850	arg1	parameters					1864:1873	the malting and brewing parameters	1840:1873	the malting and brewing parameters	1840:1873	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	9	56	theme	39.5	1610:1613	arg1	%					1614:1614	%	1614:1614	%	1614:1614	A KI value of about 39.5% to 42.7% was therefore considered optimal for the production of wheat malts with superior quality attributes.
33929729	5	57	from	changes	966:972	arg1	concentration					981:993	the concentration	977:993	the concentration of individual albumin fractions	977:1025	As for albumins, although their overall concentration had increased as KI increased, changes in the concentration of individual albumin fractions was more complex.
33929729	2	58	dep	characterization	411:426	arg1	i					408:408	i	408:408	i	408:408	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	5	59	theme	overall	913:919	arg1	concentration					921:933	their overall concentration	907:933	their overall concentration	907:933	As for albumins, although their overall concentration had increased as KI increased, changes in the concentration of individual albumin fractions was more complex.
33929729	6	60	dep	64.3 kDa	1209:1216	arg1	to					1206:1207	to	1206:1207	to	1206:1207	While there were significant increases in the concentration of some new albumin proteins (43.8 and 84.4 kDa), the concentration of some albumins decreased (21.1 to 64.3 kDa), and some fractions had completely disappeared (28.8 and 64.3 kDa).
33929729	0	61	theme	modification	42:53	arg1	index					25:29	the index	21:29	the index of protein modification (Kolbach index)	21:69	Relationship between the index of protein modification (Kolbach index) and degradation of macromolecules in wheat malt.
33929729	0	61	theme	modification	42:53	arg1	index					64:68	index	64:68	index	64:68	Relationship between the index of protein modification (Kolbach index) and degradation of macromolecules in wheat malt.
33929729	0	61	theme	modification	42:53	arg1	degradation					75:85	degradation	75:85	degradation of macromolecules in wheat malt	75:117	Relationship between the index of protein modification (Kolbach index) and degradation of macromolecules in wheat malt.
33929729	1	62	theme	other	266:270	arg1	macromolecules					272:285	other macromolecules	266:285	other macromolecules	266:285	Kolbach index (KI) is an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting.
33929729	5	63	theme	albumin	1009:1015	arg1	fractions					1017:1025	individual albumin fractions	998:1025	individual albumin fractions	998:1025	As for albumins, although their overall concentration had increased as KI increased, changes in the concentration of individual albumin fractions was more complex.
33929729	7	64	theme	KI	1376:1377	arg1	values					1379:1384	higher KI values	1369:1384	higher KI values	1369:1384	Following mashing, the hydrophobicity of the worts had decreased significantly at higher KI values.
33929729	2	65	dep	Triticum	368:375	arg1	L.					386:387	Triticum aestivum L.	368:387	Triticum aestivum L.	368:387	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	10	66	theme	PRACTICAL	1726:1734	arg1	APPLICATION					1736:1746	PRACTICAL APPLICATION	1726:1746	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.	1726:1966	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	10	67	theme	parameters	1864:1873	arg1	control					1829:1835	a more precise control	1814:1835	a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer,	1814:1949	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	6	68	theme	albumins	1181:1188	arg1	concentration					1159:1171	the concentration	1155:1171	the concentration of some albumins	1155:1188	While there were significant increases in the concentration of some new albumin proteins (43.8 and 84.4 kDa), the concentration of some albumins decreased (21.1 to 64.3 kDa), and some fractions had completely disappeared (28.8 and 64.3 kDa).
33929729	3	69	theme	malt	590:593	arg1	values					598:603	malt KI values	590:603	malt KI values	590:603	As malt KI values increased, all fractions of glutenins and gliadins were extensively hydrolyzed.
33929729	9	70	with	production	1666:1675	arg1	attributes					1714:1723	superior quality attributes	1697:1723	superior quality attributes	1697:1723	A KI value of about 39.5% to 42.7% was therefore considered optimal for the production of wheat malts with superior quality attributes.
33929729	8	71	theme	enzymatic	1434:1442	arg1	activity					1444:1451	the enzymatic activity	1430:1451	the enzymatic activity	1430:1451	At malt KI values between 39.5% and 42.7%, the enzymatic activity was at its highest, the degradation of starch was adequate and stable, and the concentration of water-soluble arabinoxylans was optimal.
33929729	10	72	theme	precise	1821:1827	arg1	control					1829:1835	a more precise control	1814:1835	a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer,	1814:1949	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	4	73	theme	Mw	696:697	arg1	70.8 kDa					718:725	70.8 kDa	718:725	70.8 kDa	718:725	The higher Mw globulins (36.6 to 70.8 kDa) were also increasingly degraded at higher KI values, but the concentration of smaller globulin fractions (14.9 to 35.0 kDa) had increased significantly.
33929729	4	73	theme	Mw	696:697	arg1	globulins					699:707	The higher Mw globulins	685:707	The higher Mw globulins (36.6 to 70.8 kDa)	685:726	The higher Mw globulins (36.6 to 70.8 kDa) were also increasingly degraded at higher KI values, but the concentration of smaller globulin fractions (14.9 to 35.0 kDa) had increased significantly.
33929729	10	74	theme	beer	1945:1948	arg1	production					1896:1905	the production	1892:1905	the production of high-quality wheat malts and wheat beer	1892:1948	PRACTICAL APPLICATION: The findings from this study will be valuable to beer companies; a more precise control of the malting and brewing parameters, fundamental for the production of high-quality wheat malts and wheat beer, can be achieved.
33929729	1	75	theme	Kolbach	120:126	arg1	index					155:159	an important index	142:159	an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting	142:318	Kolbach index (KI) is an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting.
33929729	1	75	theme	Kolbach	120:126	arg1	KI					135:136	KI	135:136	KI	135:136	Kolbach index (KI) is an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting.
33929729	1	75	theme	Kolbach	120:126	arg1	index					128:132	Kolbach index	120:132	Kolbach index (KI)	120:137	Kolbach index (KI) is an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting.
33929729	8	76	theme	starch	1492:1497	arg1	adequate					1503:1510	adequate	1503:1510	adequate	1503:1510	At malt KI values between 39.5% and 42.7%, the enzymatic activity was at its highest, the degradation of starch was adequate and stable, and the concentration of water-soluble arabinoxylans was optimal.
33929729	8	76	theme	starch	1492:1497	arg1	degradation					1477:1487	the degradation	1473:1487	the degradation of starch	1473:1497	At malt KI values between 39.5% and 42.7%, the enzymatic activity was at its highest, the degradation of starch was adequate and stable, and the concentration of water-soluble arabinoxylans was optimal.
33929729	1	77	theme	malt	190:193	arg1	qualities					177:185	the qualities	173:185	the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting	173:318	Kolbach index (KI) is an important index to evaluate the qualities of malt, which will affect protein molecular composition, enzyme activity, and other macromolecules degradation during wheat malting.
33929729	2	78	theme	albumins	431:438	arg1	KI					396:397	KI	396:397	KI	396:397	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	2	78	theme	albumins	431:438	arg1	characterization					411:426	the (i) characterization	403:426	the (i) characterization	403:426	In this paper, the relationship between wheat (Triticum aestivum L.) malts KI and the (i) characterization of albumins, globulins, gliadins, and glutenins and their hydrolysis and (ii) the enzymatic breakdown of starch and arabinoxylans during malting were studied.
33929729	0	79	from	degradation	75:85	arg1	malt					114:117	wheat malt	108:117	wheat malt	108:117	Relationship between the index of protein modification (Kolbach index) and degradation of macromolecules in wheat malt.
33929729	4	80	dep	35.0 kDa	842:849	arg1	to					839:840	to	839:840	to	839:840	The higher Mw globulins (36.6 to 70.8 kDa) were also increasingly degraded at higher KI values, but the concentration of smaller globulin fractions (14.9 to 35.0 kDa) had increased significantly.
33929729	6	81	theme	significant	1062:1072	arg1	increases					1074:1082	significant increases	1062:1082	significant increases in the concentration of some new albumin proteins	1062:1132	While there were significant increases in the concentration of some new albumin proteins (43.8 and 84.4 kDa), the concentration of some albumins decreased (21.1 to 64.3 kDa), and some fractions had completely disappeared (28.8 and 64.3 kDa).
33929729	0	82	from	index	25:29	arg1	malt					114:117	wheat malt	108:117	wheat malt	108:117	Relationship between the index of protein modification (Kolbach index) and degradation of macromolecules in wheat malt.
33929729	9	83	theme	%	1623:1623	arg1	value					1595:1599	A KI value	1590:1599	A KI value of about 39.5% to 42.7%	1590:1623	A KI value of about 39.5% to 42.7% was therefore considered optimal for the production of wheat malts with superior quality attributes.
33929729	9	84	theme	wheat	1680:1684	arg1	malts					1686:1690	wheat malts	1680:1690	wheat malts	1680:1690	A KI value of about 39.5% to 42.7% was therefore considered optimal for the production of wheat malts with superior quality attributes.
32681120	4	0	theme	enzymatic	564:572	arg1	hydrolysis					574:583	enzymatic hydrolysis	564:583	enzymatic hydrolysis	564:583	It requires chemical-based treatment or enzymatic hydrolysis to cleave the chitin polymers.
32681120	10	1	theme	Placket-Burman	1187:1200	arg1	models					1243:1248	Placket-Burman and central composite design statistical models	1187:1248	Placket-Burman and central composite design statistical models for culture condition optimisation	1187:1283	Placket-Burman and central composite design statistical models for culture condition optimisation predicted a 464.2 U/ml of chitinase production.
32681120	12	2	from	xylosoxidans	1457:1468	arg1	chitinase					1435:1443	This chitinase	1430:1443	This chitinase from the A. xylosoxidans	1430:1468	This chitinase from the A. xylosoxidans was 100% active at an optimum temperature of 45 °C (withstand up to 55 °C) and pH 8 with 80% stability.
32681120	2	3	from	rise	326:329	arg1	industries					344:353	shellfish industries	334:353	shellfish industries	334:353	Notably, the rise in shellfish industries contributes to tons of shellfish waste composed of up to 58% chitin.
32681120	5	4	theme	environmental	657:669	arg1	pollution					671:679	environmental pollution	657:679	environmental pollution	657:679	The chemical-based treatment can lead to environmental pollution, so to solve this problem, enzymatic hydrolysis is the best option.
32681120	9	5	theme	chitin	1164:1169	arg1	medium					1179:1184	chitin minimal medium	1164:1184	chitin minimal medium	1164:1184	So we isolate a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site using chitin minimal medium.
32681120	13	6	theme	HPLC	1578:1581	arg1	analysis					1583:1590	The HPLC analysis	1574:1590	The HPLC analysis of chitinase degraded shellfish waste	1574:1628	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	6	7	theme	delivery	857:864	arg1	agents					866:871	drug delivery agents	852:871	drug delivery agents	852:871	Moreover, the resulting biopolymer by-products can be used to boost the fish immune system and also as drug delivery agents.
32681120	6	8	theme	biopolymer	773:782	arg1	by-products					784:794	the resulting biopolymer by-products	759:794	the resulting biopolymer by-products	759:794	Moreover, the resulting biopolymer by-products can be used to boost the fish immune system and also as drug delivery agents.
32681120	1	9	theme	significant	188:198	arg1	issue					200:204	a significant issue	186:204	a significant issue in recent decades	186:222	Marine pollution is a significant issue in recent decades, with the increase in industries and their waste harming the environment and ecosystems.
32681120	1	9	theme	significant	188:198	arg1	pollution					173:181	Marine pollution	166:181	Marine pollution	166:181	Marine pollution is a significant issue in recent decades, with the increase in industries and their waste harming the environment and ecosystems.
32681120	8	10	theme	economical	969:978	arg1	enzyme					1008:1013	an economical and highly stable chitinase enzyme	966:1013	an economical and highly stable chitinase enzyme for use in the industrial sector	966:1046	Nevertheless, we still lack an economical and highly stable chitinase enzyme for use in the industrial sector.
32681120	13	11	theme	low	1733:1735	arg1	levels					1737:1742	low levels	1733:1742	low levels	1733:1742	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	11	12	theme	culture	1337:1343	arg1	conditions					1345:1354	The culture conditions	1333:1354	The culture conditions	1333:1354	The culture conditions were optimised for maximum chitinase production recording up to 467 U/ml.
32681120	0	13	theme	shrimp	138:143	arg1	area					160:163	shrimp waste disposal area	138:163	shrimp waste disposal area	138:163	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.
32681120	12	14	from	temperature	1500:1510	arg1	active					1479:1484	active	1479:1484	active	1479:1484	This chitinase from the A. xylosoxidans was 100% active at an optimum temperature of 45 °C (withstand up to 55 °C) and pH 8 with 80% stability.
32681120	11	15	theme	chitinase	1383:1391	arg1	production					1393:1402	maximum chitinase production	1375:1402	maximum chitinase production recording up to 467 U/ml	1375:1427	The culture conditions were optimised for maximum chitinase production recording up to 467 U/ml.
32681120	0	16	theme	disposal	151:158	arg1	area					160:163	shrimp waste disposal area	138:163	shrimp waste disposal area	138:163	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.
32681120	6	17	used	used	803:806	arg2	by-products					784:794	the resulting biopolymer by-products	759:794	the resulting biopolymer by-products	759:794	Moreover, the resulting biopolymer by-products can be used to boost the fish immune system and also as drug delivery agents.
32681120	13	18	dep	acid	1652:1655	arg1	composition-arginine					1665:1684	profile composition-arginine	1657:1684	profile composition-arginine	1657:1684	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	12	19	theme	80	1559:1560	arg1	%					1561:1561	%	1561:1561	%	1561:1561	This chitinase from the A. xylosoxidans was 100% active at an optimum temperature of 45 °C (withstand up to 55 °C) and pH 8 with 80% stability.
32681120	11	20	dep	467 U/ml	1420:1427	arg1	up					1414:1415	up	1414:1415	up	1414:1415	The culture conditions were optimised for maximum chitinase production recording up to 467 U/ml.
32681120	10	21	theme	design	1224:1229	arg1	models					1243:1248	Placket-Burman and central composite design statistical models	1187:1248	Placket-Burman and central composite design statistical models for culture condition optimisation	1187:1283	Placket-Burman and central composite design statistical models for culture condition optimisation predicted a 464.2 U/ml of chitinase production.
32681120	12	22	dep	temperature	1500:1510	arg1	up					1532:1533	withstand up	1522:1533	withstand up to 55 °C	1522:1542	This chitinase from the A. xylosoxidans was 100% active at an optimum temperature of 45 °C (withstand up to 55 °C) and pH 8 with 80% stability.
32681120	1	23	from	increase	234:241	arg1	industries					246:255	industries	246:255	industries	246:255	Marine pollution is a significant issue in recent decades, with the increase in industries and their waste harming the environment and ecosystems.
32681120	1	23	from	increase	234:241	arg1	waste					267:271	their waste	261:271	their waste harming the environment and ecosystems	261:310	Marine pollution is a significant issue in recent decades, with the increase in industries and their waste harming the environment and ecosystems.
32681120	1	24	from	issue	200:204	arg1	decades					216:222	recent decades	209:222	recent decades	209:222	Marine pollution is a significant issue in recent decades, with the increase in industries and their waste harming the environment and ecosystems.
32681120	10	25	theme	production	1321:1330	arg1	464.2 U/ml					1297:1306	a 464.2 U/ml	1295:1306	a 464.2 U/ml of chitinase production	1295:1330	Placket-Burman and central composite design statistical models for culture condition optimisation predicted a 464.2 U/ml of chitinase production.
32681120	10	26	theme	central	1206:1212	arg1	models					1243:1248	Placket-Burman and central composite design statistical models	1187:1248	Placket-Burman and central composite design statistical models for culture condition optimisation	1187:1283	Placket-Burman and central composite design statistical models for culture condition optimisation predicted a 464.2 U/ml of chitinase production.
32681120	1	27	theme	Marine	166:171	arg1	issue					200:204	a significant issue	186:204	a significant issue in recent decades	186:222	Marine pollution is a significant issue in recent decades, with the increase in industries and their waste harming the environment and ecosystems.
32681120	1	27	theme	Marine	166:171	arg1	pollution					173:181	Marine pollution	166:181	Marine pollution	166:181	Marine pollution is a significant issue in recent decades, with the increase in industries and their waste harming the environment and ecosystems.
32681120	9	28	from	site	1153:1156	arg1	xylosoxidans					1109:1120	a novel marine bacterial strain Achromobacter xylosoxidans	1063:1120	a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site	1063:1156	So we isolate a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site using chitin minimal medium.
32681120	10	29	theme	culture	1254:1260	arg1	optimisation					1272:1283	culture condition optimisation	1254:1283	culture condition optimisation	1254:1283	Placket-Burman and central composite design statistical models for culture condition optimisation predicted a 464.2 U/ml of chitinase production.
32681120	8	30	theme	chitinase	998:1006	arg1	enzyme					1008:1013	an economical and highly stable chitinase enzyme	966:1013	an economical and highly stable chitinase enzyme for use in the industrial sector	966:1046	Nevertheless, we still lack an economical and highly stable chitinase enzyme for use in the industrial sector.
32681120	13	31	theme	aspartic	1695:1702	arg1	acid					1704:1707	aspartic acid	1695:1707	aspartic acid	1695:1707	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	0	32	theme	Achromobacter	97:109	arg1	xylosoxidans					111:122	novel Achromobacter xylosoxidans	91:122	novel Achromobacter xylosoxidans	91:122	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.
32681120	9	33	theme	marine	1071:1076	arg1	xylosoxidans					1109:1120	a novel marine bacterial strain Achromobacter xylosoxidans	1063:1120	a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site	1063:1156	So we isolate a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site using chitin minimal medium.
32681120	2	34	dep	chitin	416:421	arg1	%					414:414	%	414:414	%	414:414	Notably, the rise in shellfish industries contributes to tons of shellfish waste composed of up to 58% chitin.
32681120	7	35	theme	chitinase	909:917	arg1	ability					929:935	chitinase producing ability	909:935	chitinase producing ability	909:935	Many marine microbial strains have chitinase producing ability.
32681120	12	36	with	active	1479:1484	arg1	stability					1563:1571	80% stability	1559:1571	80% stability	1559:1571	This chitinase from the A. xylosoxidans was 100% active at an optimum temperature of 45 °C (withstand up to 55 °C) and pH 8 with 80% stability.
32681120	0	37	theme	N-acetylglucosamine	68:86	arg1	chitin					17:22	chitin	17:22	chitin	17:22	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.
32681120	0	37	theme	N-acetylglucosamine	68:86	arg1	production					40:49	concomitant production	28:49	concomitant production of chitinase and N-acetylglucosamine	28:86	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.
32681120	2	38	theme	waste	388:392	arg1	tons					370:373	tons	370:373	tons of shellfish waste composed of up to 58% chitin	370:421	Notably, the rise in shellfish industries contributes to tons of shellfish waste composed of up to 58% chitin.
32681120	8	39	theme	industrial	1030:1039	arg1	sector					1041:1046	the industrial sector	1026:1046	the industrial sector	1026:1046	Nevertheless, we still lack an economical and highly stable chitinase enzyme for use in the industrial sector.
32681120	9	40	theme	novel	1065:1069	arg1	xylosoxidans					1109:1120	a novel marine bacterial strain Achromobacter xylosoxidans	1063:1120	a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site	1063:1156	So we isolate a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site using chitin minimal medium.
32681120	3	41	theme	most	443:446	arg1	Chitin					424:429	Chitin	424:429	Chitin	424:429	Chitin, the second most ample polymer next to cellulose, is insoluble and resistant to degradation.
32681120	3	41	theme	most	443:446	arg1	polymer					454:460	the second most ample polymer	432:460	the second most ample polymer next to cellulose	432:478	Chitin, the second most ample polymer next to cellulose, is insoluble and resistant to degradation.
32681120	0	42	theme	chitin	17:22	arg1	Bioconversion					0:12	Bioconversion	0:12	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans	0:122	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.
32681120	12	43	theme	45 °C	1515:1519	arg1	pH					1549:1550	pH 8	1549:1552	pH 8	1549:1552	This chitinase from the A. xylosoxidans was 100% active at an optimum temperature of 45 °C (withstand up to 55 °C) and pH 8 with 80% stability.
32681120	12	43	theme	45 °C	1515:1519	arg1	temperature					1500:1510	an optimum temperature	1489:1510	an optimum temperature of 45 °C (withstand up to 55 °C)	1489:1543	This chitinase from the A. xylosoxidans was 100% active at an optimum temperature of 45 °C (withstand up to 55 °C) and pH 8 with 80% stability.
32681120	4	44	theme	chemical-based	536:549	arg1	treatment					551:559	chemical-based treatment	536:559	chemical-based treatment	536:559	It requires chemical-based treatment or enzymatic hydrolysis to cleave the chitin polymers.
32681120	13	45	theme	major	1640:1644	arg1	acid					1652:1655	a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels	1638:1742	acid	1652:1655	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	9	46	theme	bacterial	1078:1086	arg1	xylosoxidans					1109:1120	a novel marine bacterial strain Achromobacter xylosoxidans	1063:1120	a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site	1063:1156	So we isolate a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site using chitin minimal medium.
32681120	0	47	theme	concomitant	28:38	arg1	production					40:49	concomitant production	28:49	concomitant production of chitinase and N-acetylglucosamine	28:86	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.
32681120	12	48	theme	withstand	1522:1530	arg1	up					1532:1533	withstand up	1522:1533	withstand up to 55 °C	1522:1542	This chitinase from the A. xylosoxidans was 100% active at an optimum temperature of 45 °C (withstand up to 55 °C) and pH 8 with 80% stability.
32681120	2	49	dep	%	414:414	arg1	58					412:413	58	412:413	58	412:413	Notably, the rise in shellfish industries contributes to tons of shellfish waste composed of up to 58% chitin.
32681120	9	50	theme	Achromobacter	1095:1107	arg1	xylosoxidans					1109:1120	a novel marine bacterial strain Achromobacter xylosoxidans	1063:1120	a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site	1063:1156	So we isolate a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site using chitin minimal medium.
32681120	6	51	theme	fish	821:824	arg1	system					833:838	the fish immune system	817:838	the fish immune system	817:838	Moreover, the resulting biopolymer by-products can be used to boost the fish immune system and also as drug delivery agents.
32681120	13	52	theme	shellfish	1614:1622	arg1	waste					1624:1628	chitinase degraded shellfish waste	1595:1628	chitinase degraded shellfish waste	1595:1628	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	7	53	theme	microbial	886:894	arg1	strains					896:902	Many marine microbial strains	874:902	Many marine microbial strains	874:902	Many marine microbial strains have chitinase producing ability.
32681120	9	54	theme	shrimp	1131:1136	arg1	site					1153:1156	the shrimp waste disposal site	1127:1156	the shrimp waste disposal site	1127:1156	So we isolate a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site using chitin minimal medium.
32681120	7	55	theme	Many	874:877	arg1	strains					896:902	Many marine microbial strains	874:902	Many marine microbial strains	874:902	Many marine microbial strains have chitinase producing ability.
32681120	4	56	theme	chitin	599:604	arg1	polymers					606:613	the chitin polymers	595:613	the chitin polymers	595:613	It requires chemical-based treatment or enzymatic hydrolysis to cleave the chitin polymers.
32681120	9	57	theme	disposal	1144:1151	arg1	site					1153:1156	the shrimp waste disposal site	1127:1156	the shrimp waste disposal site	1127:1156	So we isolate a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site using chitin minimal medium.
32681120	13	58	theme	isoleucine	1747:1756	arg1	acid					1704:1707	aspartic acid	1695:1707	aspartic acid	1695:1707	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	13	58	theme	isoleucine	1747:1756	arg1	acid					1652:1655	a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels	1638:1742	acid	1652:1655	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	13	58	theme	isoleucine	1747:1756	arg1	levels					1737:1742	low levels	1733:1742	low levels	1733:1742	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	13	58	theme	isoleucine	1747:1756	arg1	alanine					1710:1716	alanine	1710:1716	alanine	1710:1716	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	13	58	theme	isoleucine	1747:1756	arg1	threonine					1719:1727	threonine	1719:1727	threonine	1719:1727	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	13	58	theme	isoleucine	1747:1756	arg1	lysine					1687:1692	lysine	1687:1692	lysine	1687:1692	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	13	59	theme	methionine	1762:1771	arg1	acid					1704:1707	aspartic acid	1695:1707	aspartic acid	1695:1707	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	13	59	theme	methionine	1762:1771	arg1	acid					1652:1655	a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels	1638:1742	acid	1652:1655	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	13	59	theme	methionine	1762:1771	arg1	levels					1737:1742	low levels	1733:1742	low levels	1733:1742	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	13	59	theme	methionine	1762:1771	arg1	alanine					1710:1716	alanine	1710:1716	alanine	1710:1716	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	13	59	theme	methionine	1762:1771	arg1	threonine					1719:1727	threonine	1719:1727	threonine	1719:1727	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	13	59	theme	methionine	1762:1771	arg1	lysine					1687:1692	lysine	1687:1692	lysine	1687:1692	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	9	60	theme	minimal	1171:1177	arg1	medium					1179:1184	chitin minimal medium	1164:1184	chitin minimal medium	1164:1184	So we isolate a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site using chitin minimal medium.
32681120	13	61	dep	degraded	1605:1612	arg1	chitinase					1595:1603	chitinase	1595:1603	chitinase	1595:1603	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	6	62	theme	drug	852:855	arg1	agents					866:871	drug delivery agents	852:871	drug delivery agents	852:871	Moreover, the resulting biopolymer by-products can be used to boost the fish immune system and also as drug delivery agents.
32681120	7	63	contain	have	904:907	arg1	strains					896:902	Many marine microbial strains	874:902	Many marine microbial strains	874:902	Many marine microbial strains have chitinase producing ability.
32681120	7	63	contain	have	904:907	arg2	ability					929:935	chitinase producing ability	909:935	chitinase producing ability	909:935	Many marine microbial strains have chitinase producing ability.
32681120	5	64	theme	chemical-based	620:633	arg1	treatment					635:643	The chemical-based treatment	616:643	The chemical-based treatment	616:643	The chemical-based treatment can lead to environmental pollution, so to solve this problem, enzymatic hydrolysis is the best option.
32681120	6	65	theme	resulting	763:771	arg1	by-products					784:794	the resulting biopolymer by-products	759:794	the resulting biopolymer by-products	759:794	Moreover, the resulting biopolymer by-products can be used to boost the fish immune system and also as drug delivery agents.
32681120	8	66	theme	stable	991:996	arg1	enzyme					1008:1013	an economical and highly stable chitinase enzyme	966:1013	an economical and highly stable chitinase enzyme for use in the industrial sector	966:1046	Nevertheless, we still lack an economical and highly stable chitinase enzyme for use in the industrial sector.
32681120	0	67	theme	waste	145:149	arg1	area					160:163	shrimp waste disposal area	138:163	shrimp waste disposal area	138:163	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.
32681120	1	68	theme	recent	209:214	arg1	decades					216:222	recent decades	209:222	recent decades	209:222	Marine pollution is a significant issue in recent decades, with the increase in industries and their waste harming the environment and ecosystems.
32681120	8	69	from	enzyme	1008:1013	arg1	sector					1041:1046	the industrial sector	1026:1046	the industrial sector	1026:1046	Nevertheless, we still lack an economical and highly stable chitinase enzyme for use in the industrial sector.
32681120	11	70	theme	maximum	1375:1381	arg1	production					1393:1402	maximum chitinase production	1375:1402	maximum chitinase production recording up to 467 U/ml	1375:1427	The culture conditions were optimised for maximum chitinase production recording up to 467 U/ml.
32681120	14	71	theme	aquaculture	1858:1868	arg1	industry					1870:1877	the aquaculture industry	1854:1877	the aquaculture industry	1854:1877	These chitinase degraded products and by-products can be used as supplements in the aquaculture industry.
32681120	12	72	theme	%	1561:1561	arg1	stability					1563:1571	80% stability	1559:1571	80% stability	1559:1571	This chitinase from the A. xylosoxidans was 100% active at an optimum temperature of 45 °C (withstand up to 55 °C) and pH 8 with 80% stability.
32681120	14	73	used	used	1831:1834	arg2	products					1799:1806	These chitinase degraded products	1774:1806	These chitinase degraded products	1774:1806	These chitinase degraded products and by-products can be used as supplements in the aquaculture industry.
32681120	14	73	used	used	1831:1834	arg2	supplements					1839:1849	supplements	1839:1849	supplements	1839:1849	These chitinase degraded products and by-products can be used as supplements in the aquaculture industry.
32681120	14	73	used	used	1831:1834	arg2	by-products					1812:1822	by-products	1812:1822	by-products	1812:1822	These chitinase degraded products and by-products can be used as supplements in the aquaculture industry.
32681120	10	74	theme	statistical	1231:1241	arg1	models					1243:1248	Placket-Burman and central composite design statistical models	1187:1248	Placket-Burman and central composite design statistical models for culture condition optimisation	1187:1283	Placket-Burman and central composite design statistical models for culture condition optimisation predicted a 464.2 U/ml of chitinase production.
32681120	14	75	dep	degraded	1790:1797	arg1	chitinase					1780:1788	chitinase	1780:1788	chitinase	1780:1788	These chitinase degraded products and by-products can be used as supplements in the aquaculture industry.
32681120	10	76	theme	composite	1214:1222	arg1	models					1243:1248	Placket-Burman and central composite design statistical models	1187:1248	Placket-Burman and central composite design statistical models for culture condition optimisation	1187:1283	Placket-Burman and central composite design statistical models for culture condition optimisation predicted a 464.2 U/ml of chitinase production.
32681120	5	77	theme	best	736:739	arg1	option					741:746	the best option	732:746	the best option	732:746	The chemical-based treatment can lead to environmental pollution, so to solve this problem, enzymatic hydrolysis is the best option.
32681120	5	77	theme	best	736:739	arg1	hydrolysis					718:727	enzymatic hydrolysis	708:727	enzymatic hydrolysis	708:727	The chemical-based treatment can lead to environmental pollution, so to solve this problem, enzymatic hydrolysis is the best option.
32681120	10	78	theme	condition	1262:1270	arg1	optimisation					1272:1283	culture condition optimisation	1254:1283	culture condition optimisation	1254:1283	Placket-Burman and central composite design statistical models for culture condition optimisation predicted a 464.2 U/ml of chitinase production.
32681120	0	79	theme	novel	91:95	arg1	xylosoxidans					111:122	novel Achromobacter xylosoxidans	91:122	novel Achromobacter xylosoxidans	91:122	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.
32681120	5	80	theme	enzymatic	708:716	arg1	option					741:746	the best option	732:746	the best option	732:746	The chemical-based treatment can lead to environmental pollution, so to solve this problem, enzymatic hydrolysis is the best option.
32681120	5	80	theme	enzymatic	708:716	arg1	hydrolysis					718:727	enzymatic hydrolysis	708:727	enzymatic hydrolysis	708:727	The chemical-based treatment can lead to environmental pollution, so to solve this problem, enzymatic hydrolysis is the best option.
32681120	12	81	from	pH	1549:1550	arg1	active					1479:1484	active	1479:1484	active	1479:1484	This chitinase from the A. xylosoxidans was 100% active at an optimum temperature of 45 °C (withstand up to 55 °C) and pH 8 with 80% stability.
32681120	13	82	theme	profile	1657:1663	arg1	composition-arginine					1665:1684	profile composition-arginine	1657:1684	profile composition-arginine	1657:1684	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	7	83	theme	producing	919:927	arg1	ability					929:935	chitinase producing ability	909:935	chitinase producing ability	909:935	Many marine microbial strains have chitinase producing ability.
32681120	2	84	theme	shellfish	378:386	arg1	waste					388:392	shellfish waste	378:392	shellfish waste composed of up to 58% chitin	378:421	Notably, the rise in shellfish industries contributes to tons of shellfish waste composed of up to 58% chitin.
32681120	14	85	theme	degraded	1790:1797	arg1	supplements					1839:1849	supplements	1839:1849	supplements	1839:1849	These chitinase degraded products and by-products can be used as supplements in the aquaculture industry.
32681120	14	85	theme	degraded	1790:1797	arg1	by-products					1812:1822	by-products	1812:1822	by-products	1812:1822	These chitinase degraded products and by-products can be used as supplements in the aquaculture industry.
32681120	14	85	theme	degraded	1790:1797	arg1	products					1799:1806	These chitinase degraded products	1774:1806	These chitinase degraded products	1774:1806	These chitinase degraded products and by-products can be used as supplements in the aquaculture industry.
32681120	10	86	theme	chitinase	1311:1319	arg1	production					1321:1330	chitinase production	1311:1330	chitinase production	1311:1330	Placket-Burman and central composite design statistical models for culture condition optimisation predicted a 464.2 U/ml of chitinase production.
32681120	3	87	theme	ample	448:452	arg1	Chitin					424:429	Chitin	424:429	Chitin	424:429	Chitin, the second most ample polymer next to cellulose, is insoluble and resistant to degradation.
32681120	3	87	theme	ample	448:452	arg1	polymer					454:460	the second most ample polymer	432:460	the second most ample polymer next to cellulose	432:478	Chitin, the second most ample polymer next to cellulose, is insoluble and resistant to degradation.
32681120	0	88	theme	production	40:49	arg1	Bioconversion					0:12	Bioconversion	0:12	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans	0:122	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.
32681120	13	89	theme	amino	1646:1650	arg1	acid					1652:1655	a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels	1638:1742	acid	1652:1655	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	9	90	theme	strain	1088:1093	arg1	xylosoxidans					1109:1120	a novel marine bacterial strain Achromobacter xylosoxidans	1063:1120	a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site	1063:1156	So we isolate a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site using chitin minimal medium.
32681120	3	91	theme	second	436:441	arg1	Chitin					424:429	Chitin	424:429	Chitin	424:429	Chitin, the second most ample polymer next to cellulose, is insoluble and resistant to degradation.
32681120	3	91	theme	second	436:441	arg1	polymer					454:460	the second most ample polymer	432:460	the second most ample polymer next to cellulose	432:478	Chitin, the second most ample polymer next to cellulose, is insoluble and resistant to degradation.
32681120	0	92	theme	chitinase	54:62	arg1	chitin					17:22	chitin	17:22	chitin	17:22	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.
32681120	0	92	theme	chitinase	54:62	arg1	production					40:49	concomitant production	28:49	concomitant production of chitinase and N-acetylglucosamine	28:86	Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.
32681120	1	93	with	issue	200:204	arg1	increase					234:241	the increase	230:241	the increase in industries and their waste harming the environment and ecosystems	230:310	Marine pollution is a significant issue in recent decades, with the increase in industries and their waste harming the environment and ecosystems.
32681120	6	94	theme	immune	826:831	arg1	system					833:838	the fish immune system	817:838	the fish immune system	817:838	Moreover, the resulting biopolymer by-products can be used to boost the fish immune system and also as drug delivery agents.
32681120	13	95	theme	degraded	1605:1612	arg1	waste					1624:1628	chitinase degraded shellfish waste	1595:1628	chitinase degraded shellfish waste	1595:1628	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	2	96	dep	58	412:413	arg1	to					409:410	to	409:410	to	409:410	Notably, the rise in shellfish industries contributes to tons of shellfish waste composed of up to 58% chitin.
32681120	2	97	theme	shellfish	334:342	arg1	industries					344:353	shellfish industries	334:353	shellfish industries	334:353	Notably, the rise in shellfish industries contributes to tons of shellfish waste composed of up to 58% chitin.
32681120	7	98	theme	marine	879:884	arg1	strains					896:902	Many marine microbial strains	874:902	Many marine microbial strains	874:902	Many marine microbial strains have chitinase producing ability.
32681120	13	99	theme	waste	1624:1628	arg1	analysis					1583:1590	The HPLC analysis	1574:1590	The HPLC analysis of chitinase degraded shellfish waste	1574:1628	The HPLC analysis of chitinase degraded shellfish waste reveals a major amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.
32681120	12	100	theme	optimum	1492:1498	arg1	temperature					1500:1510	an optimum temperature	1489:1510	an optimum temperature of 45 °C (withstand up to 55 °C)	1489:1543	This chitinase from the A. xylosoxidans was 100% active at an optimum temperature of 45 °C (withstand up to 55 °C) and pH 8 with 80% stability.
32681120	9	101	theme	waste	1138:1142	arg1	site					1153:1156	the shrimp waste disposal site	1127:1156	the shrimp waste disposal site	1127:1156	So we isolate a novel marine bacterial strain Achromobacter xylosoxidans from the shrimp waste disposal site using chitin minimal medium.
31931055	5	0	theme	morphological	733:745	arg1	characterization					747:762	The morphological characterization	729:762	The morphological characterization	729:762	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	1	1	theme	modified	300:307	arg1	clay					309:312	modified clay	300:312	modified clay (Mt-Tbz)	300:321	In this study, the coated date palm fiber (Dpf) trays were developed using new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz).
31931055	1	1	theme	modified	300:307	arg1	Mt-Tbz					315:320	Mt-Tbz	315:320	Mt-Tbz	315:320	In this study, the coated date palm fiber (Dpf) trays were developed using new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz).
31931055	4	2	theme	elaborated	656:665	arg1	trays					678:682	The elaborated coated Dpf trays	652:682	The elaborated coated Dpf trays	652:682	The elaborated coated Dpf trays were characterized using several techniques.
31931055	1	3	theme	coated	144:149	arg1	trays					173:177	the coated date palm fiber (Dpf) trays	140:177	the coated date palm fiber (Dpf) trays	140:177	In this study, the coated date palm fiber (Dpf) trays were developed using new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz).
31931055	8	4	theme	coated	1425:1430	arg1	trays					1436:1440	the elaborated coated Dpf trays	1410:1440	the elaborated coated Dpf trays	1410:1440	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	8	4	theme	coated	1425:1430	arg1	material					1475:1482	potential bilayer material	1457:1482	potential bilayer material in the smart packaging industry	1457:1514	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	2	5	theme	biological	437:446	arg1	properties					448:457	the biological properties	433:457	the biological properties of final materials	433:476	The thiabendazolium was intercalated in the interlayer space of montmorillonite and used in order to enhance the biological properties of final materials.
31931055	1	6	theme	clay	309:312	arg1	clay					309:312	modified clay	300:312	modified clay (Mt-Tbz)	300:321	In this study, the coated date palm fiber (Dpf) trays were developed using new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz).
31931055	1	6	theme	clay	309:312	arg1	bio-composite					283:295	a bio-composite	281:295	a bio-composite of modified clay (Mt-Tbz)	281:321	In this study, the coated date palm fiber (Dpf) trays were developed using new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz).
31931055	5	7	theme	Dpf	1036:1038	arg1	trays					1040:1044	the new coated Dpf trays	1021:1044	the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa	1021:1139	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	1	8	theme	date	151:154	arg1	trays					173:177	the coated date palm fiber (Dpf) trays	140:177	the coated date palm fiber (Dpf) trays	140:177	In this study, the coated date palm fiber (Dpf) trays were developed using new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz).
31931055	1	9	theme	eco-friendly	219:230	arg1	materials					232:240	new non-toxic, and eco-friendly materials	200:240	new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz)	200:321	In this study, the coated date palm fiber (Dpf) trays were developed using new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz).
31931055	0	10	theme	palm	107:110	arg1	trays					118:122	date palm fiber trays	102:122	date palm fiber trays	102:122	Effect of chitosan/modified montmorillonite coating on the antibacterial and mechanical properties of date palm fiber trays.
31931055	0	11	from	Effect	0:5	arg1	properties					88:97	the antibacterial and mechanical properties	55:97	the antibacterial and mechanical properties of date palm fiber trays	55:122	Effect of chitosan/modified montmorillonite coating on the antibacterial and mechanical properties of date palm fiber trays.
31931055	8	12	theme	potential	1457:1465	arg1	trays					1436:1440	the elaborated coated Dpf trays	1410:1440	the elaborated coated Dpf trays	1410:1440	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	8	12	theme	potential	1457:1465	arg1	material					1475:1482	potential bilayer material	1457:1482	potential bilayer material in the smart packaging industry	1457:1514	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	5	13	theme	fibers	950:955	arg1	surface					957:963	the fibers surface	946:963	the fibers surface	946:963	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	14	dep	dispersion/distribution	833:855	arg1	improve					984:990	improve	984:990	can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa	980:1139	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	0	15	theme	date	102:105	arg1	trays					118:122	date palm fiber trays	102:122	date palm fiber trays	102:122	Effect of chitosan/modified montmorillonite coating on the antibacterial and mechanical properties of date palm fiber trays.
31931055	8	16	theme	packaging	1497:1505	arg1	industry					1507:1514	the smart packaging industry	1487:1514	the smart packaging industry	1487:1514	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	5	17	from	0.5 MPa	1124:1130	arg1	1035 MPa					1089:1096	1035 MPa	1089:1096	1035 MPa	1089:1096	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	17	from	0.5 MPa	1124:1130	arg1	strength					1110:1117	tensile strength	1102:1117	tensile strength	1102:1117	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	6	18	theme	inhibitory	1161:1170	arg1	effect					1172:1177	their inhibitory effect	1155:1177	their inhibitory effect against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa	1155:1253	In addition, their inhibitory effect against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa has been investigated.
31931055	3	19	theme	bilayer	509:515	arg1	layer					537:541	the first layer	527:541	the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process	527:649	This material was prepared as bilayer material, the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process.
31931055	3	19	theme	bilayer	509:515	arg1	material					517:524	bilayer material	509:524	bilayer material	509:524	This material was prepared as bilayer material, the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process.
31931055	3	19	theme	bilayer	509:515	arg1	material					484:491	This material	479:491	This material	479:491	This material was prepared as bilayer material, the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process.
31931055	0	20	theme	trays	118:122	arg1	properties					88:97	the antibacterial and mechanical properties	55:97	the antibacterial and mechanical properties of date palm fiber trays	55:122	Effect of chitosan/modified montmorillonite coating on the antibacterial and mechanical properties of date palm fiber trays.
31931055	5	21	theme	modified	885:892	arg1	salt					910:913	chitosan/montmorillonite modified thiabendazolium salt	860:913	chitosan/montmorillonite modified thiabendazolium salt	860:913	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	22	theme	Dpf	803:805	arg1	Cs/Mt-Tbz					807:815	Dpf@Cs/Mt-Tbz	803:815	Dpf@Cs/Mt-Tbz	803:815	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	22	theme	Dpf	803:805	arg1	trays					796:800	coated Dpf trays	785:800	coated Dpf trays (Dpf@Cs/Mt-Tbz)	785:816	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	1	23	theme	palm	156:159	arg1	trays					173:177	the coated date palm fiber (Dpf) trays	140:177	the coated date palm fiber (Dpf) trays	140:177	In this study, the coated date palm fiber (Dpf) trays were developed using new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz).
31931055	0	24	theme	fiber	112:116	arg1	trays					118:122	date palm fiber trays	102:122	date palm fiber trays	102:122	Effect of chitosan/modified montmorillonite coating on the antibacterial and mechanical properties of date palm fiber trays.
31931055	2	25	used	used	408:411	arg2	thiabendazolium					328:342	The thiabendazolium	324:342	The thiabendazolium	324:342	The thiabendazolium was intercalated in the interlayer space of montmorillonite and used in order to enhance the biological properties of final materials.
31931055	5	26	from	term	1049:1052	arg1	properties					1007:1016	the mechanical properties	992:1016	the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa	992:1139	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	27	from	330 MPa	1078:1084	arg1	modulus					1065:1071	Young's modulus	1057:1071	Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa	1057:1139	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	1	28	theme	fiber	161:165	arg1	trays					173:177	the coated date palm fiber (Dpf) trays	140:177	the coated date palm fiber (Dpf) trays	140:177	In this study, the coated date palm fiber (Dpf) trays were developed using new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz).
31931055	5	29	theme	chitosan/montmorillonite	860:883	arg1	salt					910:913	chitosan/montmorillonite modified thiabendazolium salt	860:913	chitosan/montmorillonite modified thiabendazolium salt	860:913	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	2	30	theme	final	462:466	arg1	materials					468:476	final materials	462:476	final materials	462:476	The thiabendazolium was intercalated in the interlayer space of montmorillonite and used in order to enhance the biological properties of final materials.
31931055	5	31	theme	coating	921:927	arg1	bio-composite					929:941	coating bio-composite	921:941	coating bio-composite	921:941	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	8	32	theme	smart	1491:1495	arg1	industry					1507:1514	the smart packaging industry	1487:1514	the smart packaging industry	1487:1514	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	5	33	theme	coated	785:790	arg1	Cs/Mt-Tbz					807:815	Dpf@Cs/Mt-Tbz	803:815	Dpf@Cs/Mt-Tbz	803:815	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	33	theme	coated	785:790	arg1	trays					796:800	coated Dpf trays	785:800	coated Dpf trays (Dpf@Cs/Mt-Tbz)	785:816	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	34	theme	trays	1040:1044	arg1	properties					1007:1016	the mechanical properties	992:1016	the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa	992:1139	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	3	35	theme	first	531:535	arg1	layer					537:541	the first layer	527:541	the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process	527:649	This material was prepared as bilayer material, the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process.
31931055	3	35	theme	first	531:535	arg1	material					517:524	bilayer material	509:524	bilayer material	509:524	This material was prepared as bilayer material, the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process.
31931055	1	36	theme	Dpf	168:170	arg1	trays					173:177	the coated date palm fiber (Dpf) trays	140:177	the coated date palm fiber (Dpf) trays	140:177	In this study, the coated date palm fiber (Dpf) trays were developed using new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz).
31931055	0	37	theme	montmorillonite	28:42	arg1	coating					44:50	chitosan/modified montmorillonite coating	10:50	chitosan/modified montmorillonite coating	10:50	Effect of chitosan/modified montmorillonite coating on the antibacterial and mechanical properties of date palm fiber trays.
31931055	8	38	theme	elaborated	1414:1423	arg1	trays					1436:1440	the elaborated coated Dpf trays	1410:1440	the elaborated coated Dpf trays	1410:1440	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	8	38	theme	elaborated	1414:1423	arg1	material					1475:1482	potential bilayer material	1457:1482	potential bilayer material in the smart packaging industry	1457:1514	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	3	39	dep	layer	537:541	arg1	contains					543:550	contains	543:550	contains the treated palm fibers and the second one composes of bio-composite films through coating process	543:649	This material was prepared as bilayer material, the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process.
31931055	7	40	theme	uncoated	1362:1369	arg1	trays					1371:1375	uncoated trays	1362:1375	uncoated trays	1362:1375	Furthermore, the coating layer increase also the surface hydrophobicity compared to uncoated trays.
31931055	0	41	theme	chitosan/modified	10:26	arg1	coating					44:50	chitosan/modified montmorillonite coating	10:50	chitosan/modified montmorillonite coating	10:50	Effect of chitosan/modified montmorillonite coating on the antibacterial and mechanical properties of date palm fiber trays.
31931055	1	42	theme	palm	257:260	arg1	fibers					262:267	palm fibers	257:267	palm fibers coated with a bio-composite of modified clay (Mt-Tbz)	257:321	In this study, the coated date palm fiber (Dpf) trays were developed using new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz).
31931055	8	43	theme	Dpf	1432:1434	arg1	trays					1436:1440	the elaborated coated Dpf trays	1410:1440	the elaborated coated Dpf trays	1410:1440	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	8	43	theme	Dpf	1432:1434	arg1	material					1475:1482	potential bilayer material	1457:1482	potential bilayer material in the smart packaging industry	1457:1514	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	4	44	theme	several	709:715	arg1	techniques					717:726	several techniques	709:726	several techniques	709:726	The elaborated coated Dpf trays were characterized using several techniques.
31931055	5	45	theme	Dpf	792:794	arg1	Cs/Mt-Tbz					807:815	Dpf@Cs/Mt-Tbz	803:815	Dpf@Cs/Mt-Tbz	803:815	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	45	theme	Dpf	792:794	arg1	trays					796:800	coated Dpf trays	785:800	coated Dpf trays (Dpf@Cs/Mt-Tbz)	785:816	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	46	theme	thiabendazolium	894:908	arg1	salt					910:913	chitosan/montmorillonite modified thiabendazolium salt	860:913	chitosan/montmorillonite modified thiabendazolium salt	860:913	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	47	theme	@	806:806	arg1	Cs/Mt-Tbz					807:815	Dpf@Cs/Mt-Tbz	803:815	Dpf@Cs/Mt-Tbz	803:815	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	47	theme	@	806:806	arg1	trays					796:800	coated Dpf trays	785:800	coated Dpf trays (Dpf@Cs/Mt-Tbz)	785:816	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	48	theme	mechanical	996:1005	arg1	properties					1007:1016	the mechanical properties	992:1016	the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa	992:1139	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	49	from	properties	1007:1016	arg1	term					1049:1052	term	1049:1052	term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa	1049:1139	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	2	50	theme	interlayer	368:377	arg1	space					379:383	the interlayer space	364:383	the interlayer space of montmorillonite	364:402	The thiabendazolium was intercalated in the interlayer space of montmorillonite and used in order to enhance the biological properties of final materials.
31931055	0	51	theme	coating	44:50	arg1	Effect					0:5	Effect	0:5	Effect of chitosan/modified montmorillonite coating on the antibacterial and mechanical properties of date palm fiber trays.	0:123	Effect of chitosan/modified montmorillonite coating on the antibacterial and mechanical properties of date palm fiber trays.
31931055	3	52	theme	second	584:589	arg1	composes					595:602	the second one composes	580:602	the second one composes of bio-composite films	580:625	This material was prepared as bilayer material, the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process.
31931055	3	53	theme	treated	556:562	arg1	fibers					569:574	the treated palm fibers	552:574	the treated palm fibers	552:574	This material was prepared as bilayer material, the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process.
31931055	2	54	theme	materials	468:476	arg1	properties					448:457	the biological properties	433:457	the biological properties of final materials	433:476	The thiabendazolium was intercalated in the interlayer space of montmorillonite and used in order to enhance the biological properties of final materials.
31931055	0	55	theme	antibacterial	59:71	arg1	properties					88:97	the antibacterial and mechanical properties	55:97	the antibacterial and mechanical properties of date palm fiber trays	55:122	Effect of chitosan/modified montmorillonite coating on the antibacterial and mechanical properties of date palm fiber trays.
31931055	5	56	theme	trays	775:779	arg1	characterization					747:762	The morphological characterization	729:762	The morphological characterization	729:762	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	57	theme	Young	1057:1061	arg1	modulus					1065:1071	Young's modulus	1057:1071	Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa	1057:1139	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	8	58	theme	bilayer	1467:1473	arg1	trays					1436:1440	the elaborated coated Dpf trays	1410:1440	the elaborated coated Dpf trays	1410:1440	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	8	58	theme	bilayer	1467:1473	arg1	material					1475:1482	potential bilayer material	1457:1482	potential bilayer material in the smart packaging industry	1457:1514	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	4	59	theme	Dpf	674:676	arg1	trays					678:682	The elaborated coated Dpf trays	652:682	The elaborated coated Dpf trays	652:682	The elaborated coated Dpf trays were characterized using several techniques.
31931055	5	60	theme	tensile	1102:1108	arg1	strength					1110:1117	tensile strength	1102:1117	tensile strength	1102:1117	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	7	61	theme	coating	1295:1301	arg1	layer					1303:1307	the coating layer	1291:1307	the coating layer	1291:1307	Furthermore, the coating layer increase also the surface hydrophobicity compared to uncoated trays.
31931055	5	62	theme	new	1025:1027	arg1	trays					1040:1044	the new coated Dpf trays	1021:1044	the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa	1021:1139	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	63	theme	coated	1029:1034	arg1	trays					1040:1044	the new coated Dpf trays	1021:1044	the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa	1021:1139	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	4	64	theme	coated	667:672	arg1	trays					678:682	The elaborated coated Dpf trays	652:682	The elaborated coated Dpf trays	652:682	The elaborated coated Dpf trays were characterized using several techniques.
31931055	8	65	used	used	1449:1452	arg2	material					1475:1482	potential bilayer material	1457:1482	potential bilayer material in the smart packaging industry	1457:1514	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	8	65	used	used	1449:1452	arg2	trays					1436:1440	the elaborated coated Dpf trays	1410:1440	the elaborated coated Dpf trays	1410:1440	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	3	66	theme	coating	635:641	arg1	process					643:649	coating process	635:649	coating process	635:649	This material was prepared as bilayer material, the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process.
31931055	5	67	from	trays	1040:1044	arg1	term					1049:1052	term	1049:1052	term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa	1049:1139	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	5	68	theme	salt	910:913	arg1	dispersion/distribution					833:855	a better dispersion/distribution	824:855	a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa	824:1139	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	3	69	theme	bio-composite	607:619	arg1	films					621:625	bio-composite films	607:625	bio-composite films	607:625	This material was prepared as bilayer material, the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process.
31931055	5	70	theme	trays	796:800	arg1	characterization					747:762	The morphological characterization	729:762	The morphological characterization	729:762	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	8	71	from	material	1475:1482	arg1	industry					1507:1514	the smart packaging industry	1487:1514	the smart packaging industry	1487:1514	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
31931055	1	72	theme	new	200:202	arg1	materials					232:240	new non-toxic, and eco-friendly materials	200:240	new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz)	200:321	In this study, the coated date palm fiber (Dpf) trays were developed using new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz).
31931055	0	73	theme	mechanical	77:86	arg1	properties					88:97	the antibacterial and mechanical properties	55:97	the antibacterial and mechanical properties of date palm fiber trays	55:122	Effect of chitosan/modified montmorillonite coating on the antibacterial and mechanical properties of date palm fiber trays.
31931055	3	74	theme	films	621:625	arg1	composes					595:602	the second one composes	580:602	the second one composes of bio-composite films	580:625	This material was prepared as bilayer material, the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process.
31931055	3	74	theme	films	621:625	arg1	fibers					569:574	the treated palm fibers	552:574	the treated palm fibers	552:574	This material was prepared as bilayer material, the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process.
31931055	3	75	theme	palm	564:567	arg1	fibers					569:574	the treated palm fibers	552:574	the treated palm fibers	552:574	This material was prepared as bilayer material, the first layer contains the treated palm fibers and the second one composes of bio-composite films through coating process.
31931055	5	76	theme	better	826:831	arg1	dispersion/distribution					833:855	a better dispersion/distribution	824:855	a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa	824:1139	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	1	77	theme	non-toxic	204:212	arg1	materials					232:240	new non-toxic, and eco-friendly materials	200:240	new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz)	200:321	In this study, the coated date palm fiber (Dpf) trays were developed using new non-toxic, and eco-friendly materials which are date palm fibers coated with a bio-composite of modified clay (Mt-Tbz).
31931055	5	78	theme	Dpf	771:773	arg1	trays					775:779	the Dpf trays	767:779	the Dpf trays	767:779	The morphological characterization of the Dpf trays and coated Dpf trays (Dpf@Cs/Mt-Tbz), show a better dispersion/distribution of chitosan/montmorillonite modified thiabendazolium salt based coating bio-composite on the fibers surface, these results can improve the mechanical properties of the new coated Dpf trays in term of Young's modulus from 330 MPa to 1035 MPa and tensile strength from 0.5 MPa to 4 MPa.
31931055	7	79	theme	surface	1327:1333	arg1	hydrophobicity					1335:1348	the surface hydrophobicity	1323:1348	the surface hydrophobicity compared to uncoated trays	1323:1375	Furthermore, the coating layer increase also the surface hydrophobicity compared to uncoated trays.
31931055	2	80	theme	montmorillonite	388:402	arg1	space					379:383	the interlayer space	364:383	the interlayer space of montmorillonite	364:402	The thiabendazolium was intercalated in the interlayer space of montmorillonite and used in order to enhance the biological properties of final materials.
31931055	8	81	theme	present	1382:1388	arg1	study					1390:1394	The present study	1378:1394	The present study	1378:1394	The present study suggests that the elaborated coated Dpf trays can be used as potential bilayer material in the smart packaging industry.
34906283	1	0	theme	anti-microbial	257:270	arg1	films					286:290	anti-microbial biodegradable films	257:290	anti-microbial biodegradable films	257:290	On the basis of PVA-CS, which is incorporated with Bifidocin A, anti-microbial biodegradable films were prepared, characterized by their abilities to control the Bifidocin A's total release rate into foods as needed for packaging of active foods.
34906283	8	1	theme	Bifidocin	1608:1616	arg1	A					1618:1618	Bifidocin A	1608:1618	Bifidocin A	1608:1618	The potential of Bifidocin A to deliver from the films into the food analog appropriately at low temperatures favored the obtained active films to be applied on food packaging, especially suitable for refrigerated foods.
34906283	7	2	theme	correlation	1454:1464	arg1	factors					1466:1472	High correlation factors	1449:1472	High correlation factors (R² > 0.99)	1449:1484	High correlation factors (R² > 0.99) were acquired by fitting the release data of the Bifidocin A with the negative exponential growth model.
34906283	7	2	theme	correlation	1454:1464	arg1	>					1478:1478	R² > 0.99	1475:1483	R² > 0.99	1475:1483	High correlation factors (R² > 0.99) were acquired by fitting the release data of the Bifidocin A with the negative exponential growth model.
34906283	2	3	theme	composite	584:592	arg1	films					594:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films	540:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens	540:646	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	4	4	theme	CS	917:918	arg1	films					900:904	the composite films	886:904	the composite films of PVA and CS	886:918	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	3	5	theme	power	745:749	arg1	law					751:753	power law	745:753	power law	745:753	Fick's law, power law and negative exponential growth model were applied to further study the release kinetics of Bifidocin A.
34906283	4	6	theme	better	924:929	arg1	properties					942:951	better mechanical properties	924:951	better mechanical properties	924:951	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	0	7	from	Blend	74:78	arg1	A					38:38	Bifidocin A	28:38	Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling	28:190	Controlled Release Study on Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling.
34906283	0	8	theme	Mechanistic	143:153	arg1	Assessment					155:164	Mechanistic Assessment	143:164	Mechanistic Assessment	143:164	Controlled Release Study on Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling.
34906283	8	9	theme	active	1722:1727	arg1	films					1729:1733	the obtained active films	1709:1733	the obtained active films	1709:1733	The potential of Bifidocin A to deliver from the films into the food analog appropriately at low temperatures favored the obtained active films to be applied on food packaging, especially suitable for refrigerated foods.
34906283	2	10	theme	films	726:730	arg1	activity					710:717	the anti-microbial activity	691:717	the anti-microbial activity of the films	691:730	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	3	11	theme	exponential	768:778	arg1	model					787:791	negative exponential growth model	759:791	negative exponential growth model	759:791	Fick's law, power law and negative exponential growth model were applied to further study the release kinetics of Bifidocin A.
34906283	7	12	theme	growth	1577:1582	arg1	model					1584:1588	the negative exponential growth model	1552:1588	the negative exponential growth model	1552:1588	High correlation factors (R² > 0.99) were acquired by fitting the release data of the Bifidocin A with the negative exponential growth model.
34906283	4	13	theme	PVA	909:911	arg1	films					900:904	the composite films	886:904	the composite films of PVA and CS	886:918	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	1	14	theme	active	426:431	arg1	foods					433:437	active foods	426:437	active foods	426:437	On the basis of PVA-CS, which is incorporated with Bifidocin A, anti-microbial biodegradable films were prepared, characterized by their abilities to control the Bifidocin A's total release rate into foods as needed for packaging of active foods.
34906283	3	15	theme	Bifidocin	847:855	arg1	A					857:857	Bifidocin A	847:857	Bifidocin A	847:857	Fick's law, power law and negative exponential growth model were applied to further study the release kinetics of Bifidocin A.
34906283	7	16	theme	negative	1556:1563	arg1	model					1584:1588	the negative exponential growth model	1552:1588	the negative exponential growth model	1552:1588	High correlation factors (R² > 0.99) were acquired by fitting the release data of the Bifidocin A with the negative exponential growth model.
34906283	2	17	from	substances	526:535	arg1	films					594:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films	540:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens	540:646	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	5	18	theme	diffusion	1249:1257	arg1	coeffcients					1259:1269	the diffusion coeffcients	1245:1269	the diffusion coeffcients	1245:1269	The anti-microbial was released faster at higher temperature and concentration of Bifidocin A, and the diffusion coeffcients increased significantlywith the increase of temperature and concentration.
34906283	0	19	theme	Polyvinyl	47:55	arg1	Blend					74:78	a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging	45:128	Blend	74:78	Controlled Release Study on Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling.
34906283	8	20	theme	food	1752:1755	arg1	packaging					1757:1765	food packaging	1752:1765	food packaging	1752:1765	The potential of Bifidocin A to deliver from the films into the food analog appropriately at low temperatures favored the obtained active films to be applied on food packaging, especially suitable for refrigerated foods.
34906283	0	21	from	Study	19:23	arg1	A					38:38	Bifidocin A	28:38	Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling	28:190	Controlled Release Study on Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling.
34906283	4	22	theme	suitable	1117:1124	arg1	grycerol					1136:1143	grycerol	1136:1143	grycerol	1136:1143	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	4	22	theme	suitable	1117:1124	arg1	amount					1126:1131	a suitable amount	1115:1131	a suitable amount of grycerol	1115:1143	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	1	23	theme	Bifidocin	355:363	arg1	rate					383:386	the Bifidocin A's total release rate	351:386	the Bifidocin A's total release rate into foods	351:397	On the basis of PVA-CS, which is incorporated with Bifidocin A, anti-microbial biodegradable films were prepared, characterized by their abilities to control the Bifidocin A's total release rate into foods as needed for packaging of active foods.
34906283	7	24	theme	Bifidocin	1535:1543	arg1	A					1545:1545	the Bifidocin A	1531:1545	the Bifidocin A	1531:1545	High correlation factors (R² > 0.99) were acquired by fitting the release data of the Bifidocin A with the negative exponential growth model.
34906283	1	25	dep	prepared	297:304	arg1	characterized					307:319	characterized	307:319	characterized by their abilities to control the Bifidocin A's total release rate into foods as needed for packaging of active foods	307:437	On the basis of PVA-CS, which is incorporated with Bifidocin A, anti-microbial biodegradable films were prepared, characterized by their abilities to control the Bifidocin A's total release rate into foods as needed for packaging of active foods.
34906283	5	26	theme	A	1238:1238	arg1	concentration					1211:1223	concentration	1211:1223	concentration of Bifidocin A	1211:1238	The anti-microbial was released faster at higher temperature and concentration of Bifidocin A, and the diffusion coeffcients increased significantlywith the increase of temperature and concentration.
34906283	5	26	theme	A	1238:1238	arg1	temperature					1195:1205	higher temperature	1188:1205	higher temperature	1188:1205	The anti-microbial was released faster at higher temperature and concentration of Bifidocin A, and the diffusion coeffcients increased significantlywith the increase of temperature and concentration.
34906283	1	27	theme	total	369:373	arg1	rate					383:386	the Bifidocin A's total release rate	351:386	the Bifidocin A's total release rate into foods	351:397	On the basis of PVA-CS, which is incorporated with Bifidocin A, anti-microbial biodegradable films were prepared, characterized by their abilities to control the Bifidocin A's total release rate into foods as needed for packaging of active foods.
34906283	8	28	theme	suitable	1779:1786	arg1	packaging					1757:1765	food packaging	1752:1765	food packaging	1752:1765	The potential of Bifidocin A to deliver from the films into the food analog appropriately at low temperatures favored the obtained active films to be applied on food packaging, especially suitable for refrigerated foods.
34906283	2	29	theme	active	519:524	arg1	substances					526:535	active substances	519:535	active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens	519:646	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	2	30	theme	particle	575:582	arg1	films					594:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films	540:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens	540:646	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	0	31	theme	Active	113:118	arg1	Packaging					120:128	Active Packaging	113:128	Active Packaging	113:128	Controlled Release Study on Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling.
34906283	2	32	theme	anti-microbial	472:485	arg1	effects					487:493	the anti-microbial effects	468:493	the anti-microbial effects	468:493	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	8	33	theme	refrigerated	1792:1803	arg1	foods					1805:1809	refrigerated foods	1792:1809	refrigerated foods	1792:1809	The potential of Bifidocin A to deliver from the films into the food analog appropriately at low temperatures favored the obtained active films to be applied on food packaging, especially suitable for refrigerated foods.
34906283	2	34	theme	anti-microbial	695:708	arg1	activity					710:717	the anti-microbial activity	691:717	the anti-microbial activity of the films	691:730	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	0	35	dep	Blend	74:78	arg1	Biodegradable					95:107	Particle-Based Biodegradable	80:107	Particle-Based Biodegradable	80:107	Controlled Release Study on Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling.
34906283	4	36	contain	had	920:922	arg1	films					900:904	the composite films	886:904	the composite films of PVA and CS	886:918	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	4	36	contain	had	920:922	arg2	properties					942:951	better mechanical properties	924:951	better mechanical properties	924:951	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	4	36	contain	had	920:922	arg2	activity					972:979	anti-microbial activity	957:979	anti-microbial activity	957:979	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	4	37	theme	1:1	1026:1028	arg1	PVA/CS					1030:1035	1:1 PVA/CS	1026:1035	1:1 PVA/CS	1026:1035	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	6	38	theme	A	1414:1414	arg1	endothermic					1420:1430	endothermic	1420:1430	endothermic	1420:1430	According to the thermodynamic parameters, the release of Bifidocin A was endothermic and spontaneous.
34906283	6	38	theme	A	1414:1414	arg1	release					1393:1399	the release	1389:1399	the release of Bifidocin A	1389:1414	According to the thermodynamic parameters, the release of Bifidocin A was endothermic and spontaneous.
34906283	4	39	theme	Bifidocin	1001:1009	arg1	A					1011:1011	Bifidocin A	1001:1011	Bifidocin A	1001:1011	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	0	40	theme	Bifidocin	28:36	arg1	A					38:38	Bifidocin A	28:38	Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling	28:190	Controlled Release Study on Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling.
34906283	8	41	theme	A	1618:1618	arg1	potential					1595:1603	The potential	1591:1603	The potential of Bifidocin A	1591:1618	The potential of Bifidocin A to deliver from the films into the food analog appropriately at low temperatures favored the obtained active films to be applied on food packaging, especially suitable for refrigerated foods.
34906283	1	42	dep	PVA-CS	209:214	arg1	basis					200:204	basis	200:204	basis	200:204	On the basis of PVA-CS, which is incorporated with Bifidocin A, anti-microbial biodegradable films were prepared, characterized by their abilities to control the Bifidocin A's total release rate into foods as needed for packaging of active foods.
34906283	1	42	dep	PVA-CS	209:214	arg1	the					196:198	the	196:198	the	196:198	On the basis of PVA-CS, which is incorporated with Bifidocin A, anti-microbial biodegradable films were prepared, characterized by their abilities to control the Bifidocin A's total release rate into foods as needed for packaging of active foods.
34906283	1	43	theme	Bifidocin	244:252	arg1	A					254:254	Bifidocin A	244:254	Bifidocin A	244:254	On the basis of PVA-CS, which is incorporated with Bifidocin A, anti-microbial biodegradable films were prepared, characterized by their abilities to control the Bifidocin A's total release rate into foods as needed for packaging of active foods.
34906283	7	44	theme	R²	1475:1476	arg1	factors					1466:1472	High correlation factors	1449:1472	High correlation factors (R² > 0.99)	1449:1484	High correlation factors (R² > 0.99) were acquired by fitting the release data of the Bifidocin A with the negative exponential growth model.
34906283	7	44	theme	R²	1475:1476	arg1	>					1478:1478	R² > 0.99	1475:1483	R² > 0.99	1475:1483	High correlation factors (R² > 0.99) were acquired by fitting the release data of the Bifidocin A with the negative exponential growth model.
34906283	2	45	from	films	594:598	arg1	kinetics					507:514	release kinetics	499:514	release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens	499:646	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	2	45	from	films	594:598	arg1	indicator					660:668	indicator	660:668	indicator	660:668	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	6	46	theme	thermodynamic	1363:1375	arg1	parameters					1377:1386	the thermodynamic parameters	1359:1386	the thermodynamic parameters	1359:1386	According to the thermodynamic parameters, the release of Bifidocin A was endothermic and spontaneous.
34906283	2	47	theme	PVA-CS	567:572	arg1	films					594:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films	540:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens	540:646	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	1	48	theme	biodegradable	272:284	arg1	films					286:290	anti-microbial biodegradable films	257:290	anti-microbial biodegradable films	257:290	On the basis of PVA-CS, which is incorporated with Bifidocin A, anti-microbial biodegradable films were prepared, characterized by their abilities to control the Bifidocin A's total release rate into foods as needed for packaging of active foods.
34906283	7	49	theme	High	1449:1452	arg1	factors					1466:1472	High correlation factors	1449:1472	High correlation factors (R² > 0.99)	1449:1484	High correlation factors (R² > 0.99) were acquired by fitting the release data of the Bifidocin A with the negative exponential growth model.
34906283	7	49	theme	High	1449:1452	arg1	>					1478:1478	R² > 0.99	1475:1483	R² > 0.99	1475:1483	High correlation factors (R² > 0.99) were acquired by fitting the release data of the Bifidocin A with the negative exponential growth model.
34906283	4	50	with	%	1019:1019	arg1	PVA/CS					1030:1035	1:1 PVA/CS	1026:1035	1:1 PVA/CS	1026:1035	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	8	51	theme	food	1655:1658	arg1	analog					1660:1665	the food analog	1651:1665	the food analog	1651:1665	The potential of Bifidocin A to deliver from the films into the food analog appropriately at low temperatures favored the obtained active films to be applied on food packaging, especially suitable for refrigerated foods.
34906283	4	52	theme	film	1074:1077	arg1	structure					1057:1065	the structure	1053:1065	the structure of the film, which can be resolved by including a suitable amount of grycerol	1053:1143	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	3	53	theme	negative	759:766	arg1	model					787:791	negative exponential growth model	759:791	negative exponential growth model	759:791	Fick's law, power law and negative exponential growth model were applied to further study the release kinetics of Bifidocin A.
34906283	8	54	theme	low	1684:1686	arg1	temperatures					1688:1699	low temperatures	1684:1699	low temperatures favored the obtained active films to be applied on food packaging, especially suitable for refrigerated foods	1684:1809	The potential of Bifidocin A to deliver from the films into the food analog appropriately at low temperatures favored the obtained active films to be applied on food packaging, especially suitable for refrigerated foods.
34906283	2	55	used	used	652:655	arg2	kinetics					507:514	release kinetics	499:514	release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens	499:646	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	2	55	used	used	652:655	arg2	indicator					660:668	indicator	660:668	indicator	660:668	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	2	56	theme	polyvinyl	540:548	arg1	films					594:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films	540:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens	540:646	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	2	57	from	kinetics	507:514	arg1	films					594:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films	540:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens	540:646	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	4	58	theme	grycerol	1136:1143	arg1	grycerol					1136:1143	grycerol	1136:1143	grycerol	1136:1143	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	4	58	theme	grycerol	1136:1143	arg1	amount					1126:1131	a suitable amount	1115:1131	a suitable amount of grycerol	1115:1143	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	0	59	theme	Experimental	170:181	arg1	Modeling					183:190	Experimental Modeling	170:190	Experimental Modeling	170:190	Controlled Release Study on Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling.
34906283	8	60	theme	obtained	1713:1720	arg1	films					1729:1733	the obtained active films	1709:1733	the obtained active films	1709:1733	The potential of Bifidocin A to deliver from the films into the food analog appropriately at low temperatures favored the obtained active films to be applied on food packaging, especially suitable for refrigerated foods.
34906283	7	61	theme	exponential	1565:1575	arg1	model					1584:1588	the negative exponential growth model	1552:1588	the negative exponential growth model	1552:1588	High correlation factors (R² > 0.99) were acquired by fitting the release data of the Bifidocin A with the negative exponential growth model.
34906283	4	62	theme	composite	890:898	arg1	films					900:904	the composite films	886:904	the composite films of PVA and CS	886:918	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	0	63	from	Packaging	120:128	arg1	A					38:38	Bifidocin A	28:38	Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling	28:190	Controlled Release Study on Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling.
34906283	3	64	theme	growth	780:785	arg1	model					787:791	negative exponential growth model	759:791	negative exponential growth model	759:791	Fick's law, power law and negative exponential growth model were applied to further study the release kinetics of Bifidocin A.
34906283	0	65	theme	Alcohol/Chitosan	57:72	arg1	Blend					74:78	a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging	45:128	Blend	74:78	Controlled Release Study on Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling.
34906283	1	66	theme	foods	433:437	arg1	packaging					413:421	packaging	413:421	packaging of active foods	413:437	On the basis of PVA-CS, which is incorporated with Bifidocin A, anti-microbial biodegradable films were prepared, characterized by their abilities to control the Bifidocin A's total release rate into foods as needed for packaging of active foods.
34906283	3	67	theme	A	857:857	arg1	kinetics					835:842	the release kinetics	823:842	the release kinetics of Bifidocin A	823:857	Fick's law, power law and negative exponential growth model were applied to further study the release kinetics of Bifidocin A.
34906283	7	68	theme	A	1545:1545	arg1	data					1523:1526	the release data	1511:1526	the release data of the Bifidocin A	1511:1545	High correlation factors (R² > 0.99) were acquired by fitting the release data of the Bifidocin A with the negative exponential growth model.
34906283	2	69	theme	release	499:505	arg1	kinetics					507:514	release kinetics	499:514	release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens	499:646	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	2	69	theme	release	499:505	arg1	indicator					660:668	indicator	660:668	indicator	660:668	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	4	70	theme	mechanical	931:940	arg1	properties					942:951	better mechanical properties	924:951	better mechanical properties	924:951	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	0	71	theme	Particle-Based	80:93	arg1	Biodegradable					95:107	Particle-Based Biodegradable	80:107	Particle-Based Biodegradable	80:107	Controlled Release Study on Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling.
34906283	5	72	theme	Bifidocin	1228:1236	arg1	A					1238:1238	Bifidocin A	1228:1238	Bifidocin A	1228:1238	The anti-microbial was released faster at higher temperature and concentration of Bifidocin A, and the diffusion coeffcients increased significantlywith the increase of temperature and concentration.
34906283	1	73	theme	A's	365:367	arg1	rate					383:386	the Bifidocin A's total release rate	351:386	the Bifidocin A's total release rate into foods	351:397	On the basis of PVA-CS, which is incorporated with Bifidocin A, anti-microbial biodegradable films were prepared, characterized by their abilities to control the Bifidocin A's total release rate into foods as needed for packaging of active foods.
34906283	2	74	theme	substances	526:535	arg1	kinetics					507:514	release kinetics	499:514	release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens	499:646	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	2	74	theme	substances	526:535	arg1	indicator					660:668	indicator	660:668	indicator	660:668	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	3	75	theme	release	827:833	arg1	kinetics					835:842	the release kinetics	823:842	the release kinetics of Bifidocin A	823:857	Fick's law, power law and negative exponential growth model were applied to further study the release kinetics of Bifidocin A.
34906283	1	76	theme	release	375:381	arg1	rate					383:386	the Bifidocin A's total release rate	351:386	the Bifidocin A's total release rate into foods	351:397	On the basis of PVA-CS, which is incorporated with Bifidocin A, anti-microbial biodegradable films were prepared, characterized by their abilities to control the Bifidocin A's total release rate into foods as needed for packaging of active foods.
34906283	5	77	theme	temperature	1315:1325	arg1	increase					1303:1310	the increase	1299:1310	the increase of temperature and concentration	1299:1343	The anti-microbial was released faster at higher temperature and concentration of Bifidocin A, and the diffusion coeffcients increased significantlywith the increase of temperature and concentration.
34906283	4	78	theme	anti-microbial	957:970	arg1	activity					972:979	anti-microbial activity	957:979	anti-microbial activity	957:979	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	0	79	theme	Release	11:17	arg1	Study					19:23	Release Study	11:23	Release Study on Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling	11:190	Controlled Release Study on Bifidocin A from a Polyvinyl Alcohol/Chitosan Blend Particle-Based Biodegradable and Active Packaging Coupled with Mechanistic Assessment and Experimental Modeling.
34906283	2	80	theme	alcoholchitosan	550:564	arg1	films					594:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films	540:598	polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens	540:646	This study aimed to explore the anti-microbial effects and release kinetics of active substances in polyvinyl alcoholchitosan (PVA-CS) particle composite films added with Bifidocin A. Pseudomonas fluorescens was used as indicator bacteria to evaluate the anti-microbial activity of the films.
34906283	6	81	theme	Bifidocin	1404:1412	arg1	A					1414:1414	Bifidocin A	1404:1414	Bifidocin A	1404:1414	According to the thermodynamic parameters, the release of Bifidocin A was endothermic and spontaneous.
34906283	7	82	theme	release	1515:1521	arg1	data					1523:1526	the release data	1511:1526	the release data of the Bifidocin A	1511:1545	High correlation factors (R² > 0.99) were acquired by fitting the release data of the Bifidocin A with the negative exponential growth model.
34906283	4	83	theme	A	1011:1011	arg1	%					1019:1019	50%	1017:1019	50%	1017:1019	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	4	83	theme	A	1011:1011	arg1	content					990:996	the content	986:996	the content of Bifidocin A	986:1011	The results revealed that the composite films of PVA and CS had better mechanical properties and anti-microbial activity when the content of Bifidocin A was 50% with 1:1 PVA/CS, but it impairs the structure of the film, which can be resolved by including a suitable amount of grycerol.
34906283	5	84	theme	concentration	1331:1343	arg1	increase					1303:1310	the increase	1299:1310	the increase of temperature and concentration	1299:1343	The anti-microbial was released faster at higher temperature and concentration of Bifidocin A, and the diffusion coeffcients increased significantlywith the increase of temperature and concentration.
34906283	5	85	theme	higher	1188:1193	arg1	temperature					1195:1205	higher temperature	1188:1205	higher temperature	1188:1205	The anti-microbial was released faster at higher temperature and concentration of Bifidocin A, and the diffusion coeffcients increased significantlywith the increase of temperature and concentration.
34053522	1	0	theme	microbial	371:379	arg1	changes					381:387	microbial changes	371:387	microbial changes	371:387	The concept of "enterotype" has been proposed to differentiate the gut microbiota between individual humans, and different dominant bacteria utilize fiber substrates with different fermentation properties and microbial changes.
34053522	4	1	theme	short-chain	984:994	arg1	SCFA					1009:1012	SCFA	1009:1012	SCFA	1009:1012	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	4	1	theme	short-chain	984:994	arg1	acids					1002:1006	short-chain fatty acids	984:1006	short-chain fatty acids (SCFA)	984:1013	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	0	2	theme	high-amylose	80:91	arg1	profiles					30:37	In vitro colonic fermentation profiles	0:37	In vitro colonic fermentation profiles	0:37	In vitro colonic fermentation profiles and microbial responses of propionylated high-amylose maize starch by individual Bacteroides-dominated enterotype inocula.
34053522	0	2	theme	high-amylose	80:91	arg1	responses					53:61	microbial responses	43:61	microbial responses of propionylated high-amylose	43:91	In vitro colonic fermentation profiles and microbial responses of propionylated high-amylose maize starch by individual Bacteroides-dominated enterotype inocula.
34053522	7	3	theme	therapies	1536:1544	arg1	design					1486:1491	the design	1482:1491	the design of personalized food products and relevant therapies	1482:1544	The results may offer useful information for the design of personalized food products and relevant therapies at least within Bacteroides-dominated enterotype.
34053522	1	4	theme	enterotype	178:187	arg1	"					188:188	"enterotype"	177:188	"enterotype"	177:188	The concept of "enterotype" has been proposed to differentiate the gut microbiota between individual humans, and different dominant bacteria utilize fiber substrates with different fermentation properties and microbial changes.
34053522	4	5	theme	colonic	1022:1028	arg1	fermentation					1030:1041	colonic fermentation	1022:1041	colonic fermentation	1022:1041	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	3	6	theme	gas	705:707	arg1	production					709:718	the gas production	701:718	the gas production during fermentation	701:738	Propionyl group substitution of HAMS did not significantly change gas production profiles, suggesting that the gas production during fermentation is independent of propionylation.
34053522	3	6	theme	gas	705:707	arg1	independent					743:753	independent	743:753	independent	743:753	Propionyl group substitution of HAMS did not significantly change gas production profiles, suggesting that the gas production during fermentation is independent of propionylation.
34053522	4	7	theme	acids	1002:1006	arg1	concentration					967:979	the concentration	963:979	the concentration of short-chain fatty acids (SCFA)	963:1013	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	1	8	theme	different	275:283	arg1	bacteria					294:301	different dominant bacteria	275:301	different dominant bacteria	275:301	The concept of "enterotype" has been proposed to differentiate the gut microbiota between individual humans, and different dominant bacteria utilize fiber substrates with different fermentation properties and microbial changes.
34053522	5	9	theme	genus	1051:1055	arg1	level					1057:1061	the genus level	1047:1061	the genus level	1047:1061	At the genus level, Bacteroides was obviously promoted for all donors with the final abundance in the range of 0.1-0.24, indicating that propionylated high-amylose maize starch changed the structure and abundance of microbiota compared to unmodified starch.
34053522	5	10	theme	high-amylose	1195:1206	arg1	starch					1214:1219	propionylated high-amylose maize starch	1181:1219	propionylated high-amylose maize starch	1181:1219	At the genus level, Bacteroides was obviously promoted for all donors with the final abundance in the range of 0.1-0.24, indicating that propionylated high-amylose maize starch changed the structure and abundance of microbiota compared to unmodified starch.
34053522	4	11	theme	fatty	996:1000	arg1	SCFA					1009:1012	SCFA	1009:1012	SCFA	1009:1012	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	4	11	theme	fatty	996:1000	arg1	acids					1002:1006	short-chain fatty acids	984:1006	short-chain fatty acids (SCFA)	984:1013	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	6	12	theme	non-metric	1315:1324	arg1	plots					1353:1357	the non-metric dimensional scoring (NMDS) plots	1311:1357	the non-metric dimensional scoring (NMDS) plots	1311:1357	Besides, the non-metric dimensional scoring (NMDS) plots showed that those changes were related to the initial microbiota composition.
34053522	3	13	theme	HAMS	626:629	arg1	substitution					610:621	Propionyl group substitution	594:621	Propionyl group substitution of HAMS	594:629	Propionyl group substitution of HAMS did not significantly change gas production profiles, suggesting that the gas production during fermentation is independent of propionylation.
34053522	1	14	theme	dominant	285:292	arg1	bacteria					294:301	different dominant bacteria	275:301	different dominant bacteria	275:301	The concept of "enterotype" has been proposed to differentiate the gut microbiota between individual humans, and different dominant bacteria utilize fiber substrates with different fermentation properties and microbial changes.
34053522	0	15	theme	Bacteroides-dominated	120:140	arg1	inocula					153:159	individual Bacteroides-dominated enterotype inocula	109:159	individual Bacteroides-dominated enterotype inocula	109:159	In vitro colonic fermentation profiles and microbial responses of propionylated high-amylose maize starch by individual Bacteroides-dominated enterotype inocula.
34053522	5	16	theme	maize	1208:1212	arg1	starch					1214:1219	propionylated high-amylose maize starch	1181:1219	propionylated high-amylose maize starch	1181:1219	At the genus level, Bacteroides was obviously promoted for all donors with the final abundance in the range of 0.1-0.24, indicating that propionylated high-amylose maize starch changed the structure and abundance of microbiota compared to unmodified starch.
34053522	2	17	dep	in	475:476	arg1	vitro					478:482	vitro	478:482	vitro	478:482	In this study, we made propionylated high-amylose maize starch and investigated both in vitro fecal fermentation properties and microbial responses by individual Bacteroides-dominated enterotype inocula.
34053522	3	18	theme	group	604:608	arg1	substitution					610:621	Propionyl group substitution	594:621	Propionyl group substitution of HAMS	594:629	Propionyl group substitution of HAMS did not significantly change gas production profiles, suggesting that the gas production during fermentation is independent of propionylation.
34053522	4	19	theme	degree	894:899	arg1	function					867:874	a function	865:874	a function of propionylation degree	865:899	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	1	20	theme	"	188:188	arg1	concept					166:172	The concept	162:172	The concept of "enterotype"	162:188	The concept of "enterotype" has been proposed to differentiate the gut microbiota between individual humans, and different dominant bacteria utilize fiber substrates with different fermentation properties and microbial changes.
34053522	0	21	theme	individual	109:118	arg1	inocula					153:159	individual Bacteroides-dominated enterotype inocula	109:159	individual Bacteroides-dominated enterotype inocula	109:159	In vitro colonic fermentation profiles and microbial responses of propionylated high-amylose maize starch by individual Bacteroides-dominated enterotype inocula.
34053522	7	22	theme	Bacteroides-dominated	1562:1582	arg1	enterotype					1584:1593	Bacteroides-dominated enterotype	1562:1593	Bacteroides-dominated enterotype	1562:1593	The results may offer useful information for the design of personalized food products and relevant therapies at least within Bacteroides-dominated enterotype.
34053522	2	23	theme	propionylated	413:425	arg1	starch					446:451	propionylated high-amylose maize starch	413:451	propionylated high-amylose maize starch	413:451	In this study, we made propionylated high-amylose maize starch and investigated both in vitro fecal fermentation properties and microbial responses by individual Bacteroides-dominated enterotype inocula.
34053522	2	24	theme	fecal	484:488	arg1	properties					503:512	in vitro fecal fermentation properties	475:512	in vitro fecal fermentation properties	475:512	In this study, we made propionylated high-amylose maize starch and investigated both in vitro fecal fermentation properties and microbial responses by individual Bacteroides-dominated enterotype inocula.
34053522	1	25	with	substrates	317:326	arg1	changes					381:387	microbial changes	371:387	microbial changes	371:387	The concept of "enterotype" has been proposed to differentiate the gut microbiota between individual humans, and different dominant bacteria utilize fiber substrates with different fermentation properties and microbial changes.
34053522	1	25	with	substrates	317:326	arg1	properties					356:365	different fermentation properties	333:365	different fermentation properties	333:365	The concept of "enterotype" has been proposed to differentiate the gut microbiota between individual humans, and different dominant bacteria utilize fiber substrates with different fermentation properties and microbial changes.
34053522	4	26	dep	increased	835:843	arg1	10.26-12.60 mM					846:859	10.26-12.60 mM	846:859	10.26-12.60 mM	846:859	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	0	27	theme	In	0:1	arg1	profiles					30:37	In vitro colonic fermentation profiles	0:37	In vitro colonic fermentation profiles	0:37	In vitro colonic fermentation profiles and microbial responses of propionylated high-amylose maize starch by individual Bacteroides-dominated enterotype inocula.
34053522	5	28	theme	unmodified	1283:1292	arg1	starch					1294:1299	unmodified starch	1283:1299	unmodified starch	1283:1299	At the genus level, Bacteroides was obviously promoted for all donors with the final abundance in the range of 0.1-0.24, indicating that propionylated high-amylose maize starch changed the structure and abundance of microbiota compared to unmodified starch.
34053522	5	29	theme	0.1-0.24	1155:1162	arg1	range					1146:1150	the range	1142:1150	the range of 0.1-0.24	1142:1162	At the genus level, Bacteroides was obviously promoted for all donors with the final abundance in the range of 0.1-0.24, indicating that propionylated high-amylose maize starch changed the structure and abundance of microbiota compared to unmodified starch.
34053522	3	30	theme	propionylation	758:771	arg1	production					709:718	the gas production	701:718	the gas production during fermentation	701:738	Propionyl group substitution of HAMS did not significantly change gas production profiles, suggesting that the gas production during fermentation is independent of propionylation.
34053522	3	30	theme	propionylation	758:771	arg1	independent					743:753	independent	743:753	independent	743:753	Propionyl group substitution of HAMS did not significantly change gas production profiles, suggesting that the gas production during fermentation is independent of propionylation.
34053522	5	31	from	abundance	1129:1137	arg1	range					1146:1150	the range	1142:1150	the range of 0.1-0.24	1142:1162	At the genus level, Bacteroides was obviously promoted for all donors with the final abundance in the range of 0.1-0.24, indicating that propionylated high-amylose maize starch changed the structure and abundance of microbiota compared to unmodified starch.
34053522	0	32	theme	fermentation	17:28	arg1	profiles					30:37	In vitro colonic fermentation profiles	0:37	In vitro colonic fermentation profiles	0:37	In vitro colonic fermentation profiles and microbial responses of propionylated high-amylose maize starch by individual Bacteroides-dominated enterotype inocula.
34053522	7	33	theme	relevant	1527:1534	arg1	therapies					1536:1544	relevant therapies	1527:1544	relevant therapies	1527:1544	The results may offer useful information for the design of personalized food products and relevant therapies at least within Bacteroides-dominated enterotype.
34053522	4	34	theme	propionyl	933:941	arg1	groups					943:948	the introduced propionyl groups	918:948	the introduced propionyl groups	918:948	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	7	35	theme	food	1509:1512	arg1	products					1514:1521	personalized food products	1496:1521	personalized food products	1496:1521	The results may offer useful information for the design of personalized food products and relevant therapies at least within Bacteroides-dominated enterotype.
34053522	2	36	theme	maize	440:444	arg1	starch					446:451	propionylated high-amylose maize starch	413:451	propionylated high-amylose maize starch	413:451	In this study, we made propionylated high-amylose maize starch and investigated both in vitro fecal fermentation properties and microbial responses by individual Bacteroides-dominated enterotype inocula.
34053522	0	37	theme	colonic	9:15	arg1	profiles					30:37	In vitro colonic fermentation profiles	0:37	In vitro colonic fermentation profiles	0:37	In vitro colonic fermentation profiles and microbial responses of propionylated high-amylose maize starch by individual Bacteroides-dominated enterotype inocula.
34053522	1	38	theme	fiber	311:315	arg1	substrates					317:326	fiber substrates	311:326	fiber substrates with different fermentation properties and microbial changes	311:387	The concept of "enterotype" has been proposed to differentiate the gut microbiota between individual humans, and different dominant bacteria utilize fiber substrates with different fermentation properties and microbial changes.
34053522	0	39	theme	enterotype	142:151	arg1	inocula					153:159	individual Bacteroides-dominated enterotype inocula	109:159	individual Bacteroides-dominated enterotype inocula	109:159	In vitro colonic fermentation profiles and microbial responses of propionylated high-amylose maize starch by individual Bacteroides-dominated enterotype inocula.
34053522	7	40	theme	products	1514:1521	arg1	design					1486:1491	the design	1482:1491	the design of personalized food products and relevant therapies	1482:1544	The results may offer useful information for the design of personalized food products and relevant therapies at least within Bacteroides-dominated enterotype.
34053522	2	41	theme	microbial	518:526	arg1	responses					528:536	microbial responses	518:536	microbial responses	518:536	In this study, we made propionylated high-amylose maize starch and investigated both in vitro fecal fermentation properties and microbial responses by individual Bacteroides-dominated enterotype inocula.
34053522	5	42	dep	structure	1233:1241	arg1	the					1229:1231	the	1229:1231	the	1229:1231	At the genus level, Bacteroides was obviously promoted for all donors with the final abundance in the range of 0.1-0.24, indicating that propionylated high-amylose maize starch changed the structure and abundance of microbiota compared to unmodified starch.
34053522	6	43	theme	NMDS	1347:1350	arg1	plots					1353:1357	the non-metric dimensional scoring (NMDS) plots	1311:1357	the non-metric dimensional scoring (NMDS) plots	1311:1357	Besides, the non-metric dimensional scoring (NMDS) plots showed that those changes were related to the initial microbiota composition.
34053522	5	44	with	donors	1107:1112	arg1	abundance					1129:1137	the final abundance	1119:1137	the final abundance in the range of 0.1-0.24	1119:1162	At the genus level, Bacteroides was obviously promoted for all donors with the final abundance in the range of 0.1-0.24, indicating that propionylated high-amylose maize starch changed the structure and abundance of microbiota compared to unmodified starch.
34053522	4	45	theme	introduced	922:931	arg1	groups					943:948	the introduced propionyl groups	918:948	the introduced propionyl groups	918:948	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	2	46	theme	high-amylose	427:438	arg1	starch					446:451	propionylated high-amylose maize starch	413:451	propionylated high-amylose maize starch	413:451	In this study, we made propionylated high-amylose maize starch and investigated both in vitro fecal fermentation properties and microbial responses by individual Bacteroides-dominated enterotype inocula.
34053522	2	47	theme	in	475:476	arg1	properties					503:512	in vitro fecal fermentation properties	475:512	in vitro fecal fermentation properties	475:512	In this study, we made propionylated high-amylose maize starch and investigated both in vitro fecal fermentation properties and microbial responses by individual Bacteroides-dominated enterotype inocula.
34053522	2	48	theme	enterotype	574:583	arg1	inocula					585:591	individual Bacteroides-dominated enterotype inocula	541:591	individual Bacteroides-dominated enterotype inocula	541:591	In this study, we made propionylated high-amylose maize starch and investigated both in vitro fecal fermentation properties and microbial responses by individual Bacteroides-dominated enterotype inocula.
34053522	1	49	theme	different	333:341	arg1	properties					356:365	different fermentation properties	333:365	different fermentation properties	333:365	The concept of "enterotype" has been proposed to differentiate the gut microbiota between individual humans, and different dominant bacteria utilize fiber substrates with different fermentation properties and microbial changes.
34053522	5	50	theme	propionylated	1181:1193	arg1	starch					1214:1219	propionylated high-amylose maize starch	1181:1219	propionylated high-amylose maize starch	1181:1219	At the genus level, Bacteroides was obviously promoted for all donors with the final abundance in the range of 0.1-0.24, indicating that propionylated high-amylose maize starch changed the structure and abundance of microbiota compared to unmodified starch.
34053522	3	51	theme	gas	660:662	arg1	profiles					675:682	gas production profiles	660:682	gas production profiles	660:682	Propionyl group substitution of HAMS did not significantly change gas production profiles, suggesting that the gas production during fermentation is independent of propionylation.
34053522	4	52	theme	propionate	810:819	arg1	concentration					784:796	The final concentration	774:796	The final concentration of released propionate	774:819	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	0	53	theme	microbial	43:51	arg1	responses					53:61	microbial responses	43:61	microbial responses of propionylated high-amylose	43:91	In vitro colonic fermentation profiles and microbial responses of propionylated high-amylose maize starch by individual Bacteroides-dominated enterotype inocula.
34053522	1	54	theme	fermentation	343:354	arg1	properties					356:365	different fermentation properties	333:365	different fermentation properties	333:365	The concept of "enterotype" has been proposed to differentiate the gut microbiota between individual humans, and different dominant bacteria utilize fiber substrates with different fermentation properties and microbial changes.
34053522	6	55	theme	microbiota	1413:1422	arg1	composition					1424:1434	the initial microbiota composition	1401:1434	the initial microbiota composition	1401:1434	Besides, the non-metric dimensional scoring (NMDS) plots showed that those changes were related to the initial microbiota composition.
34053522	2	56	theme	fermentation	490:501	arg1	properties					503:512	in vitro fecal fermentation properties	475:512	in vitro fecal fermentation properties	475:512	In this study, we made propionylated high-amylose maize starch and investigated both in vitro fecal fermentation properties and microbial responses by individual Bacteroides-dominated enterotype inocula.
34053522	3	57	theme	production	664:673	arg1	profiles					675:682	gas production profiles	660:682	gas production profiles	660:682	Propionyl group substitution of HAMS did not significantly change gas production profiles, suggesting that the gas production during fermentation is independent of propionylation.
34053522	4	58	theme	released	801:808	arg1	propionate					810:819	released propionate	801:819	released propionate	801:819	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	6	59	theme	scoring	1338:1344	arg1	plots					1353:1357	the non-metric dimensional scoring (NMDS) plots	1311:1357	the non-metric dimensional scoring (NMDS) plots	1311:1357	Besides, the non-metric dimensional scoring (NMDS) plots showed that those changes were related to the initial microbiota composition.
34053522	7	60	theme	useful	1459:1464	arg1	information					1466:1476	useful information	1459:1476	useful information for the design of personalized food products and relevant therapies	1459:1544	The results may offer useful information for the design of personalized food products and relevant therapies at least within Bacteroides-dominated enterotype.
34053522	6	61	theme	initial	1405:1411	arg1	composition					1424:1434	the initial microbiota composition	1401:1434	the initial microbiota composition	1401:1434	Besides, the non-metric dimensional scoring (NMDS) plots showed that those changes were related to the initial microbiota composition.
34053522	6	62	theme	dimensional	1326:1336	arg1	plots					1353:1357	the non-metric dimensional scoring (NMDS) plots	1311:1357	the non-metric dimensional scoring (NMDS) plots	1311:1357	Besides, the non-metric dimensional scoring (NMDS) plots showed that those changes were related to the initial microbiota composition.
34053522	5	63	theme	final	1123:1127	arg1	abundance					1129:1137	the final abundance	1119:1137	the final abundance in the range of 0.1-0.24	1119:1162	At the genus level, Bacteroides was obviously promoted for all donors with the final abundance in the range of 0.1-0.24, indicating that propionylated high-amylose maize starch changed the structure and abundance of microbiota compared to unmodified starch.
34053522	4	64	theme	propionylation	879:892	arg1	degree					894:899	propionylation degree	879:899	propionylation degree	879:899	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	2	65	theme	Bacteroides-dominated	552:572	arg1	inocula					585:591	individual Bacteroides-dominated enterotype inocula	541:591	individual Bacteroides-dominated enterotype inocula	541:591	In this study, we made propionylated high-amylose maize starch and investigated both in vitro fecal fermentation properties and microbial responses by individual Bacteroides-dominated enterotype inocula.
34053522	0	66	theme	propionylated	66:78	arg1	high-amylose					80:91	propionylated high-amylose	66:91	propionylated high-amylose	66:91	In vitro colonic fermentation profiles and microbial responses of propionylated high-amylose maize starch by individual Bacteroides-dominated enterotype inocula.
34053522	1	67	theme	gut	229:231	arg1	microbiota					233:242	the gut microbiota	225:242	the gut microbiota between individual humans	225:268	The concept of "enterotype" has been proposed to differentiate the gut microbiota between individual humans, and different dominant bacteria utilize fiber substrates with different fermentation properties and microbial changes.
34053522	4	68	theme	final	778:782	arg1	concentration					784:796	The final concentration	774:796	The final concentration of released propionate	774:819	The final concentration of released propionate significantly increased (10.26-12.60 mM) as a function of propionylation degree, suggesting that the introduced propionyl groups can increase the concentration of short-chain fatty acids (SCFA) during colonic fermentation.
34053522	1	69	theme	individual	252:261	arg1	humans					263:268	individual humans	252:268	individual humans	252:268	The concept of "enterotype" has been proposed to differentiate the gut microbiota between individual humans, and different dominant bacteria utilize fiber substrates with different fermentation properties and microbial changes.
34053522	2	70	theme	individual	541:550	arg1	inocula					585:591	individual Bacteroides-dominated enterotype inocula	541:591	individual Bacteroides-dominated enterotype inocula	541:591	In this study, we made propionylated high-amylose maize starch and investigated both in vitro fecal fermentation properties and microbial responses by individual Bacteroides-dominated enterotype inocula.
34053522	0	71	dep	In	0:1	arg1	vitro					3:7	vitro	3:7	vitro	3:7	In vitro colonic fermentation profiles and microbial responses of propionylated high-amylose maize starch by individual Bacteroides-dominated enterotype inocula.
34053522	3	72	theme	Propionyl	594:602	arg1	substitution					610:621	Propionyl group substitution	594:621	Propionyl group substitution of HAMS	594:629	Propionyl group substitution of HAMS did not significantly change gas production profiles, suggesting that the gas production during fermentation is independent of propionylation.
34053522	7	73	theme	personalized	1496:1507	arg1	products					1514:1521	personalized food products	1496:1521	personalized food products	1496:1521	The results may offer useful information for the design of personalized food products and relevant therapies at least within Bacteroides-dominated enterotype.
34053522	5	74	theme	microbiota	1260:1269	arg1	structure					1233:1241	structure	1233:1241	structure	1233:1241	At the genus level, Bacteroides was obviously promoted for all donors with the final abundance in the range of 0.1-0.24, indicating that propionylated high-amylose maize starch changed the structure and abundance of microbiota compared to unmodified starch.
34053522	5	74	theme	microbiota	1260:1269	arg1	abundance					1247:1255	abundance	1247:1255	abundance	1247:1255	At the genus level, Bacteroides was obviously promoted for all donors with the final abundance in the range of 0.1-0.24, indicating that propionylated high-amylose maize starch changed the structure and abundance of microbiota compared to unmodified starch.
34364935	0	0	theme	ethyl-Nα-lauroyl-l-arginate	88:114	arg1	hydrochloride					116:128	ethyl-Nα-lauroyl-l-arginate hydrochloride	88:128	ethyl-Nα-lauroyl-l-arginate hydrochloride	88:128	Characterization of chitosan film with cinnamon essential oil emulsion co-stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride and hydroxypropyl-β-cyclodextrin.
34364935	2	1	theme	composite	523:531	arg1	films					533:537	the composite films	519:537	the composite films	519:537	The micromorphology, physical and antimicrobial properties of the composite films were compared.
34364935	1	2	theme	chitosan	207:214	arg1	films					216:220	chitosan films	207:220	chitosan films	207:220	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	4	3	theme	tensile	885:891	arg1	strength					893:900	the tensile strength	881:900	the tensile strength	881:900	The incorporation of the CEO nanoemulsion co-stabilized by LAE and HPCD, reduced the adverse effects of CEO on the mechanical properties and microstructure of the film, and even slightly increased the tensile strength.
34364935	1	4	theme	films	216:220	arg1	properties					193:202	the antimicrobial properties	175:202	the antimicrobial properties of chitosan films	175:220	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	1	5	theme	%	274:274	arg1	CEO					280:282	1% and 3% v/v CEO	266:282	CEO	280:282	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	4	6	theme	nanoemulsion	713:724	arg1	incorporation					688:700	The incorporation	684:700	The incorporation of the CEO nanoemulsion	684:724	The incorporation of the CEO nanoemulsion co-stabilized by LAE and HPCD, reduced the adverse effects of CEO on the mechanical properties and microstructure of the film, and even slightly increased the tensile strength.
34364935	1	7	theme	v/v	276:278	arg1	CEO					280:282	1% and 3% v/v CEO	266:282	CEO	280:282	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	4	8	theme	CEO	788:790	arg1	effects					777:783	the adverse effects	765:783	the adverse effects of CEO on the mechanical properties and microstructure of the film	765:850	The incorporation of the CEO nanoemulsion co-stabilized by LAE and HPCD, reduced the adverse effects of CEO on the mechanical properties and microstructure of the film, and even slightly increased the tensile strength.
34364935	3	9	theme	CEO	581:583	arg1	nanoemulsion					585:596	the CEO nanoemulsion	577:596	the CEO nanoemulsion co-stabilized by LAE and HPCD	577:626	The dense structure of the CEO nanoemulsion co-stabilized by LAE and HPCD reduced the water vapor permeability and water content.
34364935	5	10	theme	films	957:961	arg1	properties					934:943	the antimicrobial properties	916:943	the antimicrobial properties of chitosan films	916:961	In addition, the antimicrobial properties of chitosan films were enhanced due to the encapsulation and emulsification effect of HPCD and LAE on CEO.
34364935	4	11	theme	mechanical	799:808	arg1	properties					810:819	mechanical properties	799:819	mechanical properties	799:819	The incorporation of the CEO nanoemulsion co-stabilized by LAE and HPCD, reduced the adverse effects of CEO on the mechanical properties and microstructure of the film, and even slightly increased the tensile strength.
34364935	4	12	theme	CEO	709:711	arg1	nanoemulsion					713:724	the CEO nanoemulsion	705:724	the CEO nanoemulsion	705:724	The incorporation of the CEO nanoemulsion co-stabilized by LAE and HPCD, reduced the adverse effects of CEO on the mechanical properties and microstructure of the film, and even slightly increased the tensile strength.
34364935	6	13	theme	based	1099:1103	arg1	films					1112:1116	the prepared chitosan based edible films	1077:1116	the prepared chitosan based edible films	1077:1116	This work indicated that the prepared chitosan based edible films had the potential to be used in the field of food packaging to improve food safety.
34364935	5	14	theme	emulsification	1006:1019	arg1	effect					1021:1026	the encapsulation and emulsification effect	984:1026	the encapsulation and emulsification effect of HPCD and LAE on CEO	984:1049	In addition, the antimicrobial properties of chitosan films were enhanced due to the encapsulation and emulsification effect of HPCD and LAE on CEO.
34364935	5	15	from	effect	1021:1026	arg1	CEO					1047:1049	CEO	1047:1049	CEO	1047:1049	In addition, the antimicrobial properties of chitosan films were enhanced due to the encapsulation and emulsification effect of HPCD and LAE on CEO.
34364935	1	16	theme	cinnamon	223:230	arg1	nanoemulsion					252:263	cinnamon essential oil (CEO) nanoemulsion	223:263	cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD)	223:415	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	2	17	theme	physical	478:485	arg1	properties					505:514	The micromorphology, physical and antimicrobial properties	457:514	The micromorphology, physical and antimicrobial properties of the composite films	457:537	The micromorphology, physical and antimicrobial properties of the composite films were compared.
34364935	4	18	from	effects	777:783	arg1	microstructure					825:838	microstructure	825:838	microstructure	825:838	The incorporation of the CEO nanoemulsion co-stabilized by LAE and HPCD, reduced the adverse effects of CEO on the mechanical properties and microstructure of the film, and even slightly increased the tensile strength.
34364935	4	18	from	effects	777:783	arg1	properties					810:819	mechanical properties	799:819	mechanical properties	799:819	The incorporation of the CEO nanoemulsion co-stabilized by LAE and HPCD, reduced the adverse effects of CEO on the mechanical properties and microstructure of the film, and even slightly increased the tensile strength.
34364935	4	19	theme	adverse	769:775	arg1	effects					777:783	the adverse effects	765:783	the adverse effects of CEO on the mechanical properties and microstructure of the film	765:850	The incorporation of the CEO nanoemulsion co-stabilized by LAE and HPCD, reduced the adverse effects of CEO on the mechanical properties and microstructure of the film, and even slightly increased the tensile strength.
34364935	6	20	theme	edible	1105:1110	arg1	films					1112:1116	the prepared chitosan based edible films	1077:1116	the prepared chitosan based edible films	1077:1116	This work indicated that the prepared chitosan based edible films had the potential to be used in the field of food packaging to improve food safety.
34364935	1	21	theme	essential	232:240	arg1	nanoemulsion					252:263	cinnamon essential oil (CEO) nanoemulsion	223:263	cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD)	223:415	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	1	22	theme	oil	242:244	arg1	nanoemulsion					252:263	cinnamon essential oil (CEO) nanoemulsion	223:263	cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD)	223:415	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	2	23	theme	micromorphology	461:475	arg1	properties					505:514	The micromorphology, physical and antimicrobial properties	457:514	The micromorphology, physical and antimicrobial properties of the composite films	457:537	The micromorphology, physical and antimicrobial properties of the composite films were compared.
34364935	5	24	theme	HPCD	1031:1034	arg1	effect					1021:1026	the encapsulation and emulsification effect	984:1026	the encapsulation and emulsification effect of HPCD and LAE on CEO	984:1049	In addition, the antimicrobial properties of chitosan films were enhanced due to the encapsulation and emulsification effect of HPCD and LAE on CEO.
34364935	3	25	theme	nanoemulsion	585:596	arg1	structure					564:572	The dense structure	554:572	The dense structure of the CEO nanoemulsion co-stabilized by LAE and HPCD	554:626	The dense structure of the CEO nanoemulsion co-stabilized by LAE and HPCD reduced the water vapor permeability and water content.
34364935	5	26	theme	LAE	1040:1042	arg1	effect					1021:1026	the encapsulation and emulsification effect	984:1026	the encapsulation and emulsification effect of HPCD and LAE on CEO	984:1049	In addition, the antimicrobial properties of chitosan films were enhanced due to the encapsulation and emulsification effect of HPCD and LAE on CEO.
34364935	0	27	theme	chitosan	20:27	arg1	Characterization					0:15	Characterization	0:15	Characterization of chitosan film with cinnamon essential oil emulsion co-stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride and hydroxypropyl-β-cyclodextrin.	0:162	Characterization of chitosan film with cinnamon essential oil emulsion co-stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride and hydroxypropyl-β-cyclodextrin.
34364935	6	28	theme	packaging	1168:1176	arg1	field					1154:1158	the field	1150:1158	the field of food packaging	1150:1176	This work indicated that the prepared chitosan based edible films had the potential to be used in the field of food packaging to improve food safety.
34364935	5	29	theme	antimicrobial	920:932	arg1	properties					934:943	the antimicrobial properties	916:943	the antimicrobial properties of chitosan films	916:961	In addition, the antimicrobial properties of chitosan films were enhanced due to the encapsulation and emulsification effect of HPCD and LAE on CEO.
34364935	1	30	theme	CEO	247:249	arg1	nanoemulsion					252:263	cinnamon essential oil (CEO) nanoemulsion	223:263	cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD)	223:415	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	0	31	theme	cinnamon	39:46	arg1	emulsion					62:69	cinnamon essential oil emulsion	39:69	cinnamon essential oil emulsion co-stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride and hydroxypropyl-β-cyclodextrin	39:161	Characterization of chitosan film with cinnamon essential oil emulsion co-stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride and hydroxypropyl-β-cyclodextrin.
34364935	1	32	theme	ethyl-Nα-lauroyl-l-arginate	299:325	arg1	LAE					342:344	LAE	342:344	LAE	342:344	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	1	32	theme	ethyl-Nα-lauroyl-l-arginate	299:325	arg1	hydrochloride					327:339	ethyl-Nα-lauroyl-l-arginate hydrochloride	299:339	ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD)	299:415	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	4	33	theme	film	847:850	arg1	microstructure					825:838	microstructure	825:838	microstructure	825:838	The incorporation of the CEO nanoemulsion co-stabilized by LAE and HPCD, reduced the adverse effects of CEO on the mechanical properties and microstructure of the film, and even slightly increased the tensile strength.
34364935	4	33	theme	film	847:850	arg1	properties					810:819	mechanical properties	799:819	mechanical properties	799:819	The incorporation of the CEO nanoemulsion co-stabilized by LAE and HPCD, reduced the adverse effects of CEO on the mechanical properties and microstructure of the film, and even slightly increased the tensile strength.
34364935	4	34	dep	properties	810:819	arg1	the					795:797	the	795:797	the	795:797	The incorporation of the CEO nanoemulsion co-stabilized by LAE and HPCD, reduced the adverse effects of CEO on the mechanical properties and microstructure of the film, and even slightly increased the tensile strength.
34364935	3	35	theme	water	669:673	arg1	content					675:681	water content	669:681	water content	669:681	The dense structure of the CEO nanoemulsion co-stabilized by LAE and HPCD reduced the water vapor permeability and water content.
34364935	6	36	theme	prepared	1081:1088	arg1	films					1112:1116	the prepared chitosan based edible films	1077:1116	the prepared chitosan based edible films	1077:1116	This work indicated that the prepared chitosan based edible films had the potential to be used in the field of food packaging to improve food safety.
34364935	2	37	theme	antimicrobial	491:503	arg1	properties					505:514	The micromorphology, physical and antimicrobial properties	457:514	The micromorphology, physical and antimicrobial properties of the composite films	457:537	The micromorphology, physical and antimicrobial properties of the composite films were compared.
34364935	2	38	theme	films	533:537	arg1	properties					505:514	The micromorphology, physical and antimicrobial properties	457:514	The micromorphology, physical and antimicrobial properties of the composite films	457:537	The micromorphology, physical and antimicrobial properties of the composite films were compared.
34364935	5	39	theme	encapsulation	988:1000	arg1	effect					1021:1026	the encapsulation and emulsification effect	984:1026	the encapsulation and emulsification effect of HPCD and LAE on CEO	984:1049	In addition, the antimicrobial properties of chitosan films were enhanced due to the encapsulation and emulsification effect of HPCD and LAE on CEO.
34364935	0	40	theme	essential	48:56	arg1	emulsion					62:69	cinnamon essential oil emulsion	39:69	cinnamon essential oil emulsion co-stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride and hydroxypropyl-β-cyclodextrin	39:161	Characterization of chitosan film with cinnamon essential oil emulsion co-stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride and hydroxypropyl-β-cyclodextrin.
34364935	6	41	theme	food	1189:1192	arg1	safety					1194:1199	food safety	1189:1199	food safety	1189:1199	This work indicated that the prepared chitosan based edible films had the potential to be used in the field of food packaging to improve food safety.
34364935	1	42	theme	chitosan	440:447	arg1	matrix					449:454	chitosan matrix	440:454	chitosan matrix	440:454	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	0	43	with	Characterization	0:15	arg1	emulsion					62:69	cinnamon essential oil emulsion	39:69	cinnamon essential oil emulsion co-stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride and hydroxypropyl-β-cyclodextrin	39:161	Characterization of chitosan film with cinnamon essential oil emulsion co-stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride and hydroxypropyl-β-cyclodextrin.
34364935	5	44	theme	chitosan	948:955	arg1	films					957:961	chitosan films	948:961	chitosan films	948:961	In addition, the antimicrobial properties of chitosan films were enhanced due to the encapsulation and emulsification effect of HPCD and LAE on CEO.
34364935	6	45	theme	food	1163:1166	arg1	packaging					1168:1176	food packaging	1163:1176	food packaging	1163:1176	This work indicated that the prepared chitosan based edible films had the potential to be used in the field of food packaging to improve food safety.
34364935	6	46	contain	had	1118:1120	arg1	films					1112:1116	the prepared chitosan based edible films	1077:1116	the prepared chitosan based edible films	1077:1116	This work indicated that the prepared chitosan based edible films had the potential to be used in the field of food packaging to improve food safety.
34364935	6	46	contain	had	1118:1120	arg2	potential					1126:1134	the potential to be used in the field of food packaging to improve food safety	1122:1199	the potential to be used in the field of food packaging to improve food safety	1122:1199	This work indicated that the prepared chitosan based edible films had the potential to be used in the field of food packaging to improve food safety.
34364935	1	47	dep	nanoemulsion	252:263	arg1	%					267:267	1% and 3% v/v CEO	266:282	%	267:267	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	1	47	dep	nanoemulsion	252:263	arg1	CEO					280:282	1% and 3% v/v CEO	266:282	CEO	280:282	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	1	48	theme	antimicrobial	179:191	arg1	properties					193:202	the antimicrobial properties	175:202	the antimicrobial properties of chitosan films	175:220	To improve the antimicrobial properties of chitosan films, cinnamon essential oil (CEO) nanoemulsion (1% and 3% v/v CEO) stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride (LAE) alone or co-stabilized by LAE and hydroxypropyl-β-cyclodextrin (HPCD) were incorporated into chitosan matrix.
34364935	3	49	theme	water	640:644	arg1	permeability					652:663	the water vapor permeability	636:663	the water vapor permeability	636:663	The dense structure of the CEO nanoemulsion co-stabilized by LAE and HPCD reduced the water vapor permeability and water content.
34364935	6	50	theme	chitosan	1090:1097	arg1	films					1112:1116	the prepared chitosan based edible films	1077:1116	the prepared chitosan based edible films	1077:1116	This work indicated that the prepared chitosan based edible films had the potential to be used in the field of food packaging to improve food safety.
34364935	0	51	theme	oil	58:60	arg1	emulsion					62:69	cinnamon essential oil emulsion	39:69	cinnamon essential oil emulsion co-stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride and hydroxypropyl-β-cyclodextrin	39:161	Characterization of chitosan film with cinnamon essential oil emulsion co-stabilized by ethyl-Nα-lauroyl-l-arginate hydrochloride and hydroxypropyl-β-cyclodextrin.
34364935	3	52	theme	vapor	646:650	arg1	permeability					652:663	the water vapor permeability	636:663	the water vapor permeability	636:663	The dense structure of the CEO nanoemulsion co-stabilized by LAE and HPCD reduced the water vapor permeability and water content.
34364935	3	53	theme	dense	558:562	arg1	structure					564:572	The dense structure	554:572	The dense structure of the CEO nanoemulsion co-stabilized by LAE and HPCD	554:626	The dense structure of the CEO nanoemulsion co-stabilized by LAE and HPCD reduced the water vapor permeability and water content.
34871752	2	0	theme	chocolate	357:365	arg1	medium					372:377	No selective T. equigenitalis chocolate agar medium	327:377	No selective T. equigenitalis chocolate agar medium	327:377	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	1	1	theme	culture	238:244	arg1	method					246:251	the culture method	234:251	the culture method according to the World Organisation for Animal Health Terrestrial Manual	234:324	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	1	1	theme	culture	238:244	arg1	method					133:138	The gold standard method	115:138	The gold standard method to isolate and identify Taylorella equigenitalis	115:187	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	2	2	theme	fastidious	474:483	arg1	nature					485:490	the fastidious nature	470:490	the fastidious nature of T. equigenitalis	470:510	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	2	3	theme	equigenitalis	343:355	arg1	medium					372:377	No selective T. equigenitalis chocolate agar medium	327:377	No selective T. equigenitalis chocolate agar medium	327:377	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	8	4	theme	acids	1320:1324	arg1	mixture					1303:1309	a mixture	1301:1309	a mixture	1301:1309	Furthermore, our findings confirm the need to supplement the selective media with a mixture of amino acids, nucleotides, and organic, mineral and vitamin compounds, translated here by Vitox supplementation.
34871752	2	5	theme	equigenitalis	498:510	arg1	nature					485:490	the fastidious nature	470:490	the fastidious nature of T. equigenitalis	470:510	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	2	5	theme	equigenitalis	498:510	arg1	presence					520:527	the presence	516:527	the presence of interfering bacteria in the genital tract of equines	516:583	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	0	6	theme	Taylorella	89:98	arg1	equigenitalis					100:112	Taylorella equigenitalis	89:112	Taylorella equigenitalis	89:112	Comparison of five basal compositions of selective chocolate agar media for isolation of Taylorella equigenitalis.
34871752	3	7	theme	equigenitalis	617:629	arg1	strains					631:637	6 T. equigenitalis strains	612:637	6 T. equigenitalis strains	612:637	Here, the growth rates of 6 T. equigenitalis strains and 7 non-T.
34871752	4	8	theme	basal	746:750	arg1	Eugon					769:773	Eugon	769:773	Eugon	769:773	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	4	8	theme	basal	746:750	arg1	Mueller-Hinton					783:796	Mueller-Hinton	783:796	Mueller-Hinton	783:796	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	4	8	theme	basal	746:750	arg1	agars					752:756	5 different basal agars	734:756	5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar	734:860	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	4	8	theme	basal	746:750	arg1	Blood					811:815	Blood	811:815	Blood	811:815	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	4	8	theme	basal	746:750	arg1	Blood					776:780	Blood	776:780	Blood	776:780	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	6	9	theme	Blood	1094:1098	arg1	agar					1100:1103	Blood, Mueller-Hinton or Tryptose Blood agar	1060:1103	agar	1100:1103	Overall, the performance of selective T. equigenitalis media could be improved by substituting Eugon or Columbia agar with Blood, Mueller-Hinton or Tryptose Blood agar.
34871752	7	10	theme	agar/supplier	1157:1169	arg1	pair					1171:1174	the basal agar/supplier pair	1147:1174	the basal agar/supplier pair using a panel of T. equigenitalis strains	1147:1216	It is nevertheless essential to validate the basal agar/supplier pair using a panel of T. equigenitalis strains.
34871752	2	11	theme	equines	577:583	arg1	tract					568:572	the genital tract	556:572	the genital tract of equines	556:583	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	7	12	theme	T.	1193:1194	arg1	strains					1210:1216	T. equigenitalis strains	1193:1216	T. equigenitalis strains	1193:1216	It is nevertheless essential to validate the basal agar/supplier pair using a panel of T. equigenitalis strains.
34871752	1	13	dep	method	133:138	arg1	isolate					143:149	isolate	143:149	isolate	143:149	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	1	13	dep	method	133:138	arg1	identify					155:162	identify	155:162	identify Taylorella equigenitalis	155:187	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	8	14	theme	amino	1314:1318	arg1	acids					1320:1324	amino acids	1314:1324	amino acids	1314:1324	Furthermore, our findings confirm the need to supplement the selective media with a mixture of amino acids, nucleotides, and organic, mineral and vitamin compounds, translated here by Vitox supplementation.
34871752	6	15	theme	Tryptose	1085:1092	arg1	agar					1100:1103	Blood, Mueller-Hinton or Tryptose Blood agar	1060:1103	agar	1100:1103	Overall, the performance of selective T. equigenitalis media could be improved by substituting Eugon or Columbia agar with Blood, Mueller-Hinton or Tryptose Blood agar.
34871752	6	16	theme	equigenitalis	978:990	arg1	media					992:996	selective T. equigenitalis media	965:996	selective T. equigenitalis media	965:996	Overall, the performance of selective T. equigenitalis media could be improved by substituting Eugon or Columbia agar with Blood, Mueller-Hinton or Tryptose Blood agar.
34871752	1	17	theme	Taylorella	164:173	arg1	equigenitalis					175:187	Taylorella equigenitalis	164:187	Taylorella equigenitalis	164:187	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	0	18	theme	equigenitalis	100:112	arg1	isolation					76:84	isolation	76:84	isolation of Taylorella equigenitalis	76:112	Comparison of five basal compositions of selective chocolate agar media for isolation of Taylorella equigenitalis.
34871752	6	19	theme	Mueller-Hinton	1067:1080	arg1	agar					1100:1103	Blood, Mueller-Hinton or Tryptose Blood agar	1060:1103	agar	1100:1103	Overall, the performance of selective T. equigenitalis media could be improved by substituting Eugon or Columbia agar with Blood, Mueller-Hinton or Tryptose Blood agar.
34871752	7	20	theme	basal	1151:1155	arg1	pair					1171:1174	the basal agar/supplier pair	1147:1174	the basal agar/supplier pair using a panel of T. equigenitalis strains	1147:1216	It is nevertheless essential to validate the basal agar/supplier pair using a panel of T. equigenitalis strains.
34871752	6	21	theme	Columbia	1041:1048	arg1	agar					1050:1053	Eugon or Columbia agar	1032:1053	Eugon or Columbia agar	1032:1053	Overall, the performance of selective T. equigenitalis media could be improved by substituting Eugon or Columbia agar with Blood, Mueller-Hinton or Tryptose Blood agar.
34871752	6	22	theme	Eugon	1032:1036	arg1	agar					1050:1053	Eugon or Columbia agar	1032:1053	Eugon or Columbia agar	1032:1053	Overall, the performance of selective T. equigenitalis media could be improved by substituting Eugon or Columbia agar with Blood, Mueller-Hinton or Tryptose Blood agar.
34871752	2	23	theme	limited	442:448	arg1	performances					450:461	limited performances	442:461	limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines	442:583	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	5	24	theme	glucose	877:883	arg1	impact					867:872	The impact	863:872	The impact of glucose and/or Vitox supplementation	863:912	The impact of glucose and/or Vitox supplementation was also investigated.
34871752	4	25	dep	agars	752:756	arg1	Eugon					769:773	Eugon	769:773	Eugon	769:773	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	4	25	dep	agars	752:756	arg1	agars					752:756	5 different basal agars	734:756	5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar	734:860	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	4	25	dep	agars	752:756	arg1	Mueller-Hinton					783:796	Mueller-Hinton	783:796	Mueller-Hinton	783:796	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	4	25	dep	agars	752:756	arg1	Blood					811:815	Blood	811:815	Blood	811:815	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	4	25	dep	agars	752:756	arg1	Blood					776:780	Blood	776:780	Blood	776:780	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	8	26	theme	compounds	1373:1381	arg1	mixture					1303:1309	a mixture	1301:1309	a mixture	1301:1309	Furthermore, our findings confirm the need to supplement the selective media with a mixture of amino acids, nucleotides, and organic, mineral and vitamin compounds, translated here by Vitox supplementation.
34871752	0	27	theme	basal	19:23	arg1	compositions					25:36	five basal compositions	14:36	five basal compositions of selective chocolate agar media	14:70	Comparison of five basal compositions of selective chocolate agar media for isolation of Taylorella equigenitalis.
34871752	1	28	theme	World	270:274	arg1	Organisation					276:287	the World Organisation	266:287	the World Organisation for Animal Health Terrestrial Manual	266:324	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	5	29	theme	Vitox	892:896	arg1	supplementation					898:912	Vitox supplementation	892:912	Vitox supplementation	892:912	The impact of glucose and/or Vitox supplementation was also investigated.
34871752	1	30	theme	contagious	194:203	arg1	agent					205:209	the contagious agent	190:209	the contagious agent of equine metritis	190:228	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	1	30	theme	contagious	194:203	arg1	method					133:138	The gold standard method	115:138	The gold standard method to isolate and identify Taylorella equigenitalis	115:187	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	2	31	theme	existing	422:429	arg1	media					431:435	the existing media	418:435	the existing media	418:435	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	2	32	theme	bacteria	544:551	arg1	nature					485:490	the fastidious nature	470:490	the fastidious nature of T. equigenitalis	470:510	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	2	32	theme	bacteria	544:551	arg1	presence					520:527	the presence	516:527	the presence of interfering bacteria in the genital tract of equines	516:583	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	2	33	from	nature	485:490	arg1	tract					568:572	the genital tract	556:572	the genital tract of equines	556:583	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	5	34	theme	supplementation	898:912	arg1	impact					867:872	The impact	863:872	The impact of glucose and/or Vitox supplementation	863:912	The impact of glucose and/or Vitox supplementation was also investigated.
34871752	2	35	theme	due	463:465	arg1	performances					450:461	limited performances	442:461	limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines	442:583	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	7	36	theme	equigenitalis	1196:1208	arg1	strains					1210:1216	T. equigenitalis strains	1193:1216	T. equigenitalis strains	1193:1216	It is nevertheless essential to validate the basal agar/supplier pair using a panel of T. equigenitalis strains.
34871752	4	37	dep	4	835:835	arg1	to					832:833	to	832:833	to	832:833	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	2	38	theme	interfering	532:542	arg1	bacteria					544:551	interfering bacteria	532:551	interfering bacteria	532:551	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	3	39	theme	strains	631:637	arg1	non-T					645:649	non-T	645:649	non-T	645:649	Here, the growth rates of 6 T. equigenitalis strains and 7 non-T.
34871752	3	39	theme	strains	631:637	arg1	rates					603:607	the growth rates	592:607	the growth rates of 6 T. equigenitalis strains	592:637	Here, the growth rates of 6 T. equigenitalis strains and 7 non-T.
34871752	0	40	theme	compositions	25:36	arg1	Comparison					0:9	Comparison	0:9	Comparison of five basal compositions of selective chocolate agar media for isolation of Taylorella equigenitalis.	0:113	Comparison of five basal compositions of selective chocolate agar media for isolation of Taylorella equigenitalis.
34871752	1	41	theme	Animal	293:298	arg1	Manual					319:324	Animal Health Terrestrial Manual	293:324	Animal Health Terrestrial Manual	293:324	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	4	42	theme	different	736:744	arg1	Eugon					769:773	Eugon	769:773	Eugon	769:773	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	4	42	theme	different	736:744	arg1	Mueller-Hinton					783:796	Mueller-Hinton	783:796	Mueller-Hinton	783:796	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	4	42	theme	different	736:744	arg1	agars					752:756	5 different basal agars	734:756	5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar	734:860	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	4	42	theme	different	736:744	arg1	Blood					811:815	Blood	811:815	Blood	811:815	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	4	42	theme	different	736:744	arg1	Blood					776:780	Blood	776:780	Blood	776:780	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	8	43	theme	nucleotides	1327:1337	arg1	mixture					1303:1309	a mixture	1301:1309	a mixture	1301:1309	Furthermore, our findings confirm the need to supplement the selective media with a mixture of amino acids, nucleotides, and organic, mineral and vitamin compounds, translated here by Vitox supplementation.
34871752	1	44	theme	equine	214:219	arg1	metritis					221:228	equine metritis	214:228	equine metritis	214:228	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	0	45	theme	chocolate	51:59	arg1	media					66:70	selective chocolate agar media	41:70	selective chocolate agar media	41:70	Comparison of five basal compositions of selective chocolate agar media for isolation of Taylorella equigenitalis.
34871752	1	46	theme	Health	300:305	arg1	Manual					319:324	Animal Health Terrestrial Manual	293:324	Animal Health Terrestrial Manual	293:324	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	6	47	theme	media	992:996	arg1	performance					950:960	the performance	946:960	the performance of selective T. equigenitalis media	946:996	Overall, the performance of selective T. equigenitalis media could be improved by substituting Eugon or Columbia agar with Blood, Mueller-Hinton or Tryptose Blood agar.
34871752	3	48	theme	T.	614:615	arg1	strains					631:637	6 T. equigenitalis strains	612:637	6 T. equigenitalis strains	612:637	Here, the growth rates of 6 T. equigenitalis strains and 7 non-T.
34871752	8	49	theme	organic	1344:1350	arg1	compounds					1373:1381	organic, mineral and vitamin compounds	1344:1381	organic, mineral and vitamin compounds	1344:1381	Furthermore, our findings confirm the need to supplement the selective media with a mixture of amino acids, nucleotides, and organic, mineral and vitamin compounds, translated here by Vitox supplementation.
34871752	2	50	attach	presence	520:527	arg1	tract					568:572	the genital tract	556:572	the genital tract of equines	556:583	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	2	50	attach	presence	520:527	arg2	equigenitalis					498:510	T. equigenitalis	495:510	T. equigenitalis	495:510	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	2	50	attach	presence	520:527	arg2	bacteria					544:551	interfering bacteria	532:551	interfering bacteria	532:551	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	2	51	theme	T.	340:341	arg1	medium					372:377	No selective T. equigenitalis chocolate agar medium	327:377	No selective T. equigenitalis chocolate agar medium	327:377	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	0	52	theme	selective	41:49	arg1	media					66:70	selective chocolate agar media	41:70	selective chocolate agar media	41:70	Comparison of five basal compositions of selective chocolate agar media for isolation of Taylorella equigenitalis.
34871752	1	53	theme	Terrestrial	307:317	arg1	Manual					319:324	Animal Health Terrestrial Manual	293:324	Animal Health Terrestrial Manual	293:324	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	8	54	theme	Vitox	1403:1407	arg1	supplementation					1409:1423	Vitox supplementation	1403:1423	Vitox supplementation	1403:1423	Furthermore, our findings confirm the need to supplement the selective media with a mixture of amino acids, nucleotides, and organic, mineral and vitamin compounds, translated here by Vitox supplementation.
34871752	2	55	theme	selective	330:338	arg1	medium					372:377	No selective T. equigenitalis chocolate agar medium	327:377	No selective T. equigenitalis chocolate agar medium	327:377	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	7	56	theme	strains	1210:1216	arg1	panel					1184:1188	a panel	1182:1188	a panel of T. equigenitalis strains	1182:1216	It is nevertheless essential to validate the basal agar/supplier pair using a panel of T. equigenitalis strains.
34871752	2	57	theme	genital	560:566	arg1	tract					568:572	the genital tract	556:572	the genital tract of equines	556:583	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	8	58	theme	mineral	1353:1359	arg1	compounds					1373:1381	organic, mineral and vitamin compounds	1344:1381	organic, mineral and vitamin compounds	1344:1381	Furthermore, our findings confirm the need to supplement the selective media with a mixture of amino acids, nucleotides, and organic, mineral and vitamin compounds, translated here by Vitox supplementation.
34871752	1	59	theme	standard	124:131	arg1	method					246:251	the culture method	234:251	the culture method according to the World Organisation for Animal Health Terrestrial Manual	234:324	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	1	59	theme	standard	124:131	arg1	method					133:138	The gold standard method	115:138	The gold standard method to isolate and identify Taylorella equigenitalis	115:187	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	1	59	theme	standard	124:131	arg1	agent					205:209	the contagious agent	190:209	the contagious agent of equine metritis	190:228	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	1	60	theme	metritis	221:228	arg1	agent					205:209	the contagious agent	190:209	the contagious agent of equine metritis	190:228	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	1	60	theme	metritis	221:228	arg1	method					133:138	The gold standard method	115:138	The gold standard method to isolate and identify Taylorella equigenitalis	115:187	The gold standard method to isolate and identify Taylorella equigenitalis, the contagious agent of equine metritis, is the culture method according to the World Organisation for Animal Health Terrestrial Manual.
34871752	4	61	theme	basal	851:855	arg1	agar					857:860	basal agar	851:860	basal agar	851:860	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	2	62	from	presence	520:527	arg1	tract					568:572	the genital tract	556:572	the genital tract of equines	556:583	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	4	63	theme	equigenitalis	652:664	arg1	strains					666:672	equigenitalis strains	652:672	equigenitalis strains	652:672	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	8	64	theme	selective	1280:1288	arg1	media					1290:1294	the selective media	1276:1294	the selective media with a mixture of amino acids, nucleotides, and organic, mineral and vitamin compounds, translated here by Vitox supplementation	1276:1423	Furthermore, our findings confirm the need to supplement the selective media with a mixture of amino acids, nucleotides, and organic, mineral and vitamin compounds, translated here by Vitox supplementation.
34871752	4	65	theme	selective	701:709	arg1	medium					711:716	Timoney's selective medium	691:716	Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar	691:860	equigenitalis strains were compared on Timoney's selective medium formulated with 5 different basal agars (Columbia, Eugon, Blood, Mueller-Hinton and Tryptose Blood) provided by 2 to 4 suppliers per basal agar.
34871752	0	66	theme	media	66:70	arg1	compositions					25:36	five basal compositions	14:36	five basal compositions of selective chocolate agar media	14:70	Comparison of five basal compositions of selective chocolate agar media for isolation of Taylorella equigenitalis.
34871752	3	67	theme	7	643:643	arg1	non-T					645:649	non-T	645:649	non-T	645:649	Here, the growth rates of 6 T. equigenitalis strains and 7 non-T.
34871752	8	68	theme	vitamin	1365:1371	arg1	compounds					1373:1381	organic, mineral and vitamin compounds	1344:1381	organic, mineral and vitamin compounds	1344:1381	Furthermore, our findings confirm the need to supplement the selective media with a mixture of amino acids, nucleotides, and organic, mineral and vitamin compounds, translated here by Vitox supplementation.
34871752	6	69	theme	Blood	1060:1064	arg1	agar					1100:1103	Blood, Mueller-Hinton or Tryptose Blood agar	1060:1103	agar	1100:1103	Overall, the performance of selective T. equigenitalis media could be improved by substituting Eugon or Columbia agar with Blood, Mueller-Hinton or Tryptose Blood agar.
34871752	6	70	theme	selective	965:973	arg1	media					992:996	selective T. equigenitalis media	965:996	selective T. equigenitalis media	965:996	Overall, the performance of selective T. equigenitalis media could be improved by substituting Eugon or Columbia agar with Blood, Mueller-Hinton or Tryptose Blood agar.
34871752	0	71	theme	agar	61:64	arg1	media					66:70	selective chocolate agar media	41:70	selective chocolate agar media	41:70	Comparison of five basal compositions of selective chocolate agar media for isolation of Taylorella equigenitalis.
34871752	3	72	theme	growth	596:601	arg1	rates					603:607	the growth rates	592:607	the growth rates of 6 T. equigenitalis strains	592:637	Here, the growth rates of 6 T. equigenitalis strains and 7 non-T.
34871752	2	73	theme	agar	367:370	arg1	medium					372:377	No selective T. equigenitalis chocolate agar medium	327:377	No selective T. equigenitalis chocolate agar medium	327:377	No selective T. equigenitalis chocolate agar medium has been developed since the 1980s and the existing media show limited performances due to the fastidious nature of T. equigenitalis and the presence of interfering bacteria in the genital tract of equines.
34871752	8	74	with	media	1290:1294	arg1	mixture					1303:1309	a mixture	1301:1309	a mixture	1301:1309	Furthermore, our findings confirm the need to supplement the selective media with a mixture of amino acids, nucleotides, and organic, mineral and vitamin compounds, translated here by Vitox supplementation.
32541112	2	0	theme	co-ions	385:391	arg1	concentration					328:340	initial Cr(VI) concentration	313:340	initial Cr(VI) concentration	313:340	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	0	theme	co-ions	385:391	arg1	time					351:354	contact time	343:354	contact time	343:354	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	0	theme	co-ions	385:391	arg1	dosage					301:306	TFR dosage	297:306	TFR dosage	297:306	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	0	theme	co-ions	385:391	arg1	temperature					357:367	temperature	357:367	temperature	357:367	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	0	theme	co-ions	385:391	arg1	pH					309:310	pH	309:310	pH	309:310	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	0	theme	co-ions	385:391	arg1	presence					373:380	presence	373:380	presence	373:380	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	1	from	concentration	328:340	arg1	medium					400:405	the medium	396:405	the medium	396:405	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	5	2	theme	diffusion	888:896	arg1	models					898:903	pseudo-second-order and intra-particle diffusion models	849:903	pseudo-second-order and intra-particle diffusion models	849:903	The kinetic data fitted to pseudo-second-order and intra-particle diffusion models suggested that the adsorption process was subject to a rate-controlling step.
32541112	3	3	theme	X-ray	594:598	arg1	XRD					613:615	XRD	613:615	XRD	613:615	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	3	3	theme	X-ray	594:598	arg1	diffraction					600:610	X-ray diffraction	594:610	X-ray diffraction (XRD)	594:616	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	2	4	from	time	351:354	arg1	medium					400:405	the medium	396:405	the medium	396:405	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	6	5	theme	AC-TFR-2	1100:1107	arg1	145.99					1114:1119	145.99	1114:1119	145.99	1114:1119	The equilibrium adsorption data fitted well to the Langmuir isotherm model, and the maximum adsorption capacities of AC-TFR-2 were 145.99, 167.22 and 174.52 mg/g at 288, 298, and 308 K, respectively.
32541112	6	5	theme	AC-TFR-2	1100:1107	arg1	capacities					1086:1095	the maximum adsorption capacities	1063:1095	the maximum adsorption capacities of AC-TFR-2	1063:1107	The equilibrium adsorption data fitted well to the Langmuir isotherm model, and the maximum adsorption capacities of AC-TFR-2 were 145.99, 167.22 and 174.52 mg/g at 288, 298, and 308 K, respectively.
32541112	1	6	theme	tannin-formaldehyde	143:161	arg1	TFR					170:172	TFR	170:172	TFR	170:172	A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads was used to remove Cr(VI) from an aqueous solution.
32541112	1	6	theme	tannin-formaldehyde	143:161	arg1	resin					163:167	tannin-formaldehyde resin	143:167	tannin-formaldehyde resin (TFR)	143:173	A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads was used to remove Cr(VI) from an aqueous solution.
32541112	5	7	theme	pseudo-second-order	849:867	arg1	models					898:903	pseudo-second-order and intra-particle diffusion models	849:903	pseudo-second-order and intra-particle diffusion models	849:903	The kinetic data fitted to pseudo-second-order and intra-particle diffusion models suggested that the adsorption process was subject to a rate-controlling step.
32541112	6	8	theme	Langmuir	1034:1041	arg1	model					1052:1056	the Langmuir isotherm model	1030:1056	the Langmuir isotherm model	1030:1056	The equilibrium adsorption data fitted well to the Langmuir isotherm model, and the maximum adsorption capacities of AC-TFR-2 were 145.99, 167.22 and 174.52 mg/g at 288, 298, and 308 K, respectively.
32541112	6	9	theme	equilibrium	987:997	arg1	data					1010:1013	The equilibrium adsorption data	983:1013	The equilibrium adsorption data	983:1013	The equilibrium adsorption data fitted well to the Langmuir isotherm model, and the maximum adsorption capacities of AC-TFR-2 were 145.99, 167.22 and 174.52 mg/g at 288, 298, and 308 K, respectively.
32541112	2	10	from	temperature	357:367	arg1	medium					400:405	the medium	396:405	the medium	396:405	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	0	11	theme	Tannin-based	0:11	arg1	biosorbent					13:22	Tannin-based biosorbent	0:22	Tannin-based biosorbent	0:22	Tannin-based biosorbent encapsulated into calcium alginate beads for Cr(VI) removal.
32541112	4	12	theme	Cr	806:807	arg1	efficiency					792:801	the efficiency	788:801	the efficiency of Cr(VI) removal	788:819	Compared with other AC-TFR adsorbents, AC-TFR-2 (mass ratio of AC:TFR = 1:1) showed an excellent adsorption capacity based on the efficiency of Cr(VI) removal.
32541112	6	13	from	K	1166:1166	arg1	145.99					1114:1119	145.99	1114:1119	145.99	1114:1119	The equilibrium adsorption data fitted well to the Langmuir isotherm model, and the maximum adsorption capacities of AC-TFR-2 were 145.99, 167.22 and 174.52 mg/g at 288, 298, and 308 K, respectively.
32541112	6	13	from	K	1166:1166	arg1	capacities					1086:1095	the maximum adsorption capacities	1063:1095	the maximum adsorption capacities of AC-TFR-2	1063:1107	The equilibrium adsorption data fitted well to the Langmuir isotherm model, and the maximum adsorption capacities of AC-TFR-2 were 145.99, 167.22 and 174.52 mg/g at 288, 298, and 308 K, respectively.
32541112	3	14	dep	transform	518:526	arg1	infrared					528:535	infrared	528:535	transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS)	518:659	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	2	15	theme	initial	313:319	arg1	concentration					328:340	initial Cr(VI) concentration	313:340	initial Cr(VI) concentration	313:340	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	15	theme	initial	313:319	arg1	dosage					301:306	TFR dosage	297:306	TFR dosage	297:306	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	16	from	presence	373:380	arg1	medium					400:405	the medium	396:405	the medium	396:405	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	17	dep	concentration	328:340	arg1	VI					324:325	VI	324:325	VI	324:325	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	0	18	dep	removal	76:82	arg1	VI					72:73	VI	72:73	VI	72:73	Tannin-based biosorbent encapsulated into calcium alginate beads for Cr(VI) removal.
32541112	4	19	theme	AC	725:726	arg1	ratio					716:720	mass ratio	711:720	mass ratio of AC	711:726	Compared with other AC-TFR adsorbents, AC-TFR-2 (mass ratio of AC:TFR = 1:1) showed an excellent adsorption capacity based on the efficiency of Cr(VI) removal.
32541112	8	20	theme	ion	1463:1465	arg1	exchange					1467:1474	ion exchange	1463:1474	ion exchange	1463:1474	The mechanism of Cr(VI) removal consisted first of reduction to Cr(III), which has a low toxicity, and then chelation onto AC-TFR-2 via ion exchange.
32541112	2	21	theme	contact	343:349	arg1	time					351:354	contact time	343:354	contact time	343:354	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	21	theme	contact	343:349	arg1	dosage					301:306	TFR dosage	297:306	TFR dosage	297:306	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	3	22	theme	photoelectron	628:640	arg1	XPS					656:658	XPS	656:658	XPS	656:658	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	3	22	theme	photoelectron	628:640	arg1	spectroscopy					642:653	X-ray photoelectron spectroscopy	622:653	X-ray photoelectron spectroscopy (XPS)	622:659	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	7	23	theme	chemical	1306:1313	arg1	adsorption					1315:1324	chemical adsorption	1306:1324	chemical adsorption	1306:1324	The thermodynamic parameters revealed that Cr(VI) removal by AC-TFR-2 was endothermic and spontaneous, and the process was chemical adsorption.
32541112	7	23	theme	chemical	1306:1313	arg1	process					1294:1300	the process	1290:1300	the process	1290:1300	The thermodynamic parameters revealed that Cr(VI) removal by AC-TFR-2 was endothermic and spontaneous, and the process was chemical adsorption.
32541112	5	24	theme	intra-particle	873:886	arg1	models					898:903	pseudo-second-order and intra-particle diffusion models	849:903	pseudo-second-order and intra-particle diffusion models	849:903	The kinetic data fitted to pseudo-second-order and intra-particle diffusion models suggested that the adsorption process was subject to a rate-controlling step.
32541112	5	25	theme	kinetic	826:832	arg1	data					834:837	The kinetic data	822:837	The kinetic data fitted to pseudo-second-order and intra-particle diffusion models	822:903	The kinetic data fitted to pseudo-second-order and intra-particle diffusion models suggested that the adsorption process was subject to a rate-controlling step.
32541112	4	26	dep	Cr	806:807	arg1	VI					809:810	VI	809:810	VI	809:810	Compared with other AC-TFR adsorbents, AC-TFR-2 (mass ratio of AC:TFR = 1:1) showed an excellent adsorption capacity based on the efficiency of Cr(VI) removal.
32541112	4	26	dep	Cr	806:807	arg1	removal					813:819	removal	813:819	Cr(VI) removal	806:819	Compared with other AC-TFR adsorbents, AC-TFR-2 (mass ratio of AC:TFR = 1:1) showed an excellent adsorption capacity based on the efficiency of Cr(VI) removal.
32541112	7	27	theme	thermodynamic	1187:1199	arg1	parameters					1201:1210	The thermodynamic parameters	1183:1210	The thermodynamic parameters	1183:1210	The thermodynamic parameters revealed that Cr(VI) removal by AC-TFR-2 was endothermic and spontaneous, and the process was chemical adsorption.
32541112	3	28	theme	adsorption	446:455	arg1	performances					457:468	adsorption performances	446:468	adsorption performances	446:468	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	3	29	dep	Fourier	510:516	arg1	transform					518:526	transform	518:526	transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS)	518:659	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	7	30	dep	Cr	1226:1227	arg1	removal					1233:1239	removal	1233:1239	Cr(VI) removal by AC-TFR-2	1226:1251	The thermodynamic parameters revealed that Cr(VI) removal by AC-TFR-2 was endothermic and spontaneous, and the process was chemical adsorption.
32541112	7	30	dep	Cr	1226:1227	arg1	VI					1229:1230	VI	1229:1230	VI	1229:1230	The thermodynamic parameters revealed that Cr(VI) removal by AC-TFR-2 was endothermic and spontaneous, and the process was chemical adsorption.
32541112	4	31	theme	adsorption	759:768	arg1	capacity					770:777	an excellent adsorption capacity	746:777	an excellent adsorption capacity based on the efficiency of Cr(VI) removal	746:819	Compared with other AC-TFR adsorbents, AC-TFR-2 (mass ratio of AC:TFR = 1:1) showed an excellent adsorption capacity based on the efficiency of Cr(VI) removal.
32541112	2	32	from	co-ions	385:391	arg1	medium					400:405	the medium	396:405	the medium	396:405	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	1	33	theme	composite	87:95	arg1	AC-TFR					109:114	AC-TFR	109:114	AC-TFR	109:114	A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads was used to remove Cr(VI) from an aqueous solution.
32541112	1	33	theme	composite	87:95	arg1	biosorbent					97:106	A composite biosorbent	85:106	A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads	85:206	A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads was used to remove Cr(VI) from an aqueous solution.
32541112	1	34	theme	calcium	180:186	arg1	beads					202:206	calcium alginate (AC) beads	180:206	calcium alginate (AC) beads	180:206	A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads was used to remove Cr(VI) from an aqueous solution.
32541112	0	35	theme	alginate	50:57	arg1	beads					59:63	calcium alginate beads	42:63	calcium alginate beads	42:63	Tannin-based biosorbent encapsulated into calcium alginate beads for Cr(VI) removal.
32541112	3	36	theme	X-ray	622:626	arg1	XPS					656:658	XPS	656:658	XPS	656:658	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	3	36	theme	X-ray	622:626	arg1	spectroscopy					642:653	X-ray photoelectron spectroscopy	622:653	X-ray photoelectron spectroscopy (XPS)	622:659	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	6	37	theme	maximum	1067:1073	arg1	145.99					1114:1119	145.99	1114:1119	145.99	1114:1119	The equilibrium adsorption data fitted well to the Langmuir isotherm model, and the maximum adsorption capacities of AC-TFR-2 were 145.99, 167.22 and 174.52 mg/g at 288, 298, and 308 K, respectively.
32541112	6	37	theme	maximum	1067:1073	arg1	capacities					1086:1095	the maximum adsorption capacities	1063:1095	the maximum adsorption capacities of AC-TFR-2	1063:1107	The equilibrium adsorption data fitted well to the Langmuir isotherm model, and the maximum adsorption capacities of AC-TFR-2 were 145.99, 167.22 and 174.52 mg/g at 288, 298, and 308 K, respectively.
32541112	1	38	theme	alginate	188:195	arg1	beads					202:206	calcium alginate (AC) beads	180:206	calcium alginate (AC) beads	180:206	A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads was used to remove Cr(VI) from an aqueous solution.
32541112	0	39	theme	calcium	42:48	arg1	beads					59:63	calcium alginate beads	42:63	calcium alginate beads	42:63	Tannin-based biosorbent encapsulated into calcium alginate beads for Cr(VI) removal.
32541112	4	40	dep	=	732:732	arg1	ratio					716:720	mass ratio	711:720	mass ratio of AC	711:726	Compared with other AC-TFR adsorbents, AC-TFR-2 (mass ratio of AC:TFR = 1:1) showed an excellent adsorption capacity based on the efficiency of Cr(VI) removal.
32541112	5	41	theme	adsorption	924:933	arg1	subject					947:953	subject	947:953	subject	947:953	The kinetic data fitted to pseudo-second-order and intra-particle diffusion models suggested that the adsorption process was subject to a rate-controlling step.
32541112	5	41	theme	adsorption	924:933	arg1	process					935:941	the adsorption process	920:941	the adsorption process	920:941	The kinetic data fitted to pseudo-second-order and intra-particle diffusion models suggested that the adsorption process was subject to a rate-controlling step.
32541112	6	42	theme	adsorption	1075:1084	arg1	145.99					1114:1119	145.99	1114:1119	145.99	1114:1119	The equilibrium adsorption data fitted well to the Langmuir isotherm model, and the maximum adsorption capacities of AC-TFR-2 were 145.99, 167.22 and 174.52 mg/g at 288, 298, and 308 K, respectively.
32541112	6	42	theme	adsorption	1075:1084	arg1	capacities					1086:1095	the maximum adsorption capacities	1063:1095	the maximum adsorption capacities of AC-TFR-2	1063:1107	The equilibrium adsorption data fitted well to the Langmuir isotherm model, and the maximum adsorption capacities of AC-TFR-2 were 145.99, 167.22 and 174.52 mg/g at 288, 298, and 308 K, respectively.
32541112	2	43	from	pH	309:310	arg1	medium					400:405	the medium	396:405	the medium	396:405	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	44	theme	Cr	321:322	arg1	concentration					328:340	initial Cr(VI) concentration	313:340	initial Cr(VI) concentration	313:340	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	44	theme	Cr	321:322	arg1	dosage					301:306	TFR dosage	297:306	TFR dosage	297:306	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	1	45	theme	aqueous	242:248	arg1	solution					250:257	an aqueous solution	239:257	an aqueous solution	239:257	A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads was used to remove Cr(VI) from an aqueous solution.
32541112	1	46	used	used	212:215	arg2	biosorbent					97:106	A composite biosorbent	85:106	A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads	85:206	A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads was used to remove Cr(VI) from an aqueous solution.
32541112	1	46	used	used	212:215	arg2	AC-TFR					109:114	AC-TFR	109:114	AC-TFR	109:114	A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads was used to remove Cr(VI) from an aqueous solution.
32541112	3	47	theme	adsorbents	477:486	arg1	structures					431:440	structures	431:440	structures	431:440	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	3	47	theme	adsorbents	477:486	arg1	performances					457:468	adsorption performances	446:468	adsorption performances	446:468	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	8	48	theme	Cr	1344:1345	arg1	mechanism					1331:1339	The mechanism	1327:1339	The mechanism of Cr	1327:1345	The mechanism of Cr(VI) removal consisted first of reduction to Cr(III), which has a low toxicity, and then chelation onto AC-TFR-2 via ion exchange.
32541112	4	49	theme	mass	711:714	arg1	ratio					716:720	mass ratio	711:720	mass ratio of AC	711:726	Compared with other AC-TFR adsorbents, AC-TFR-2 (mass ratio of AC:TFR = 1:1) showed an excellent adsorption capacity based on the efficiency of Cr(VI) removal.
32541112	4	50	dep	AC-TFR-2	701:708	arg1	=					732:732	=	732:732	=	732:732	Compared with other AC-TFR adsorbents, AC-TFR-2 (mass ratio of AC:TFR = 1:1) showed an excellent adsorption capacity based on the efficiency of Cr(VI) removal.
32541112	1	51	dep	Cr	227:228	arg1	VI					230:231	VI	230:231	VI	230:231	A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads was used to remove Cr(VI) from an aqueous solution.
32541112	8	52	theme	low	1412:1414	arg1	toxicity					1416:1423	a low toxicity	1410:1423	a low toxicity	1410:1423	The mechanism of Cr(VI) removal consisted first of reduction to Cr(III), which has a low toxicity, and then chelation onto AC-TFR-2 via ion exchange.
32541112	6	53	theme	isotherm	1043:1050	arg1	model					1052:1056	the Langmuir isotherm model	1030:1056	the Langmuir isotherm model	1030:1056	The equilibrium adsorption data fitted well to the Langmuir isotherm model, and the maximum adsorption capacities of AC-TFR-2 were 145.99, 167.22 and 174.52 mg/g at 288, 298, and 308 K, respectively.
32541112	4	54	theme	excellent	749:757	arg1	capacity					770:777	an excellent adsorption capacity	746:777	an excellent adsorption capacity based on the efficiency of Cr(VI) removal	746:819	Compared with other AC-TFR adsorbents, AC-TFR-2 (mass ratio of AC:TFR = 1:1) showed an excellent adsorption capacity based on the efficiency of Cr(VI) removal.
32541112	2	55	from	medium	400:405	arg1	concentration					328:340	initial Cr(VI) concentration	313:340	initial Cr(VI) concentration	313:340	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	55	from	medium	400:405	arg1	time					351:354	contact time	343:354	contact time	343:354	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	55	from	medium	400:405	arg1	dosage					301:306	TFR dosage	297:306	TFR dosage	297:306	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	55	from	medium	400:405	arg1	temperature					357:367	temperature	357:367	temperature	357:367	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	55	from	medium	400:405	arg1	pH					309:310	pH	309:310	pH	309:310	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	55	from	medium	400:405	arg1	presence					373:380	presence	373:380	presence	373:380	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	8	56	contain	has	1406:1408	arg2	toxicity					1416:1423	a low toxicity	1410:1423	a low toxicity	1410:1423	The mechanism of Cr(VI) removal consisted first of reduction to Cr(III), which has a low toxicity, and then chelation onto AC-TFR-2 via ion exchange.
32541112	8	56	contain	has	1406:1408	arg1	reduction					1378:1386	reduction	1378:1386	reduction	1378:1386	The mechanism of Cr(VI) removal consisted first of reduction to Cr(III), which has a low toxicity, and then chelation onto AC-TFR-2 via ion exchange.
32541112	2	57	theme	influencing	268:278	arg1	factors					280:286	Various influencing factors	260:286	Various influencing factors	260:286	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	57	theme	influencing	268:278	arg1	dosage					301:306	TFR dosage	297:306	TFR dosage	297:306	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	6	58	theme	adsorption	999:1008	arg1	data					1010:1013	The equilibrium adsorption data	983:1013	The equilibrium adsorption data	983:1013	The equilibrium adsorption data fitted well to the Langmuir isotherm model, and the maximum adsorption capacities of AC-TFR-2 were 145.99, 167.22 and 174.52 mg/g at 288, 298, and 308 K, respectively.
32541112	1	59	theme	AC	198:199	arg1	beads					202:206	calcium alginate (AC) beads	180:206	calcium alginate (AC) beads	180:206	A composite biosorbent (AC-TFR) prepared by encapsulating tannin-formaldehyde resin (TFR) into calcium alginate (AC) beads was used to remove Cr(VI) from an aqueous solution.
32541112	3	60	theme	scanning	558:565	arg1	SEM					588:590	SEM	588:590	SEM	588:590	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	3	60	theme	scanning	558:565	arg1	microscopy					576:585	scanning electron microscopy	558:585	scanning electron microscopy (SEM)	558:591	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	2	61	theme	Various	260:266	arg1	factors					280:286	Various influencing factors	260:286	Various influencing factors	260:286	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	61	theme	Various	260:266	arg1	dosage					301:306	TFR dosage	297:306	TFR dosage	297:306	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	3	62	dep	structures	431:440	arg1	The					427:429	The	427:429	The	427:429	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	3	63	theme	electron	567:574	arg1	SEM					588:590	SEM	588:590	SEM	588:590	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	3	63	theme	electron	567:574	arg1	microscopy					576:585	scanning electron microscopy	558:585	scanning electron microscopy (SEM)	558:591	The structures and adsorption performances of the adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS).
32541112	4	64	theme	AC-TFR	682:687	arg1	adsorbents					689:698	other AC-TFR adsorbents	676:698	other AC-TFR adsorbents	676:698	Compared with other AC-TFR adsorbents, AC-TFR-2 (mass ratio of AC:TFR = 1:1) showed an excellent adsorption capacity based on the efficiency of Cr(VI) removal.
32541112	0	65	theme	Cr	69:70	arg1	removal					76:82	Cr(VI) removal	69:82	Cr(VI) removal	69:82	Tannin-based biosorbent encapsulated into calcium alginate beads for Cr(VI) removal.
32541112	5	66	theme	rate-controlling	960:975	arg1	step					977:980	a rate-controlling step	958:980	a rate-controlling step	958:980	The kinetic data fitted to pseudo-second-order and intra-particle diffusion models suggested that the adsorption process was subject to a rate-controlling step.
32541112	4	67	theme	other	676:680	arg1	adsorbents					689:698	other AC-TFR adsorbents	676:698	other AC-TFR adsorbents	676:698	Compared with other AC-TFR adsorbents, AC-TFR-2 (mass ratio of AC:TFR = 1:1) showed an excellent adsorption capacity based on the efficiency of Cr(VI) removal.
32541112	2	68	theme	TFR	297:299	arg1	concentration					328:340	initial Cr(VI) concentration	313:340	initial Cr(VI) concentration	313:340	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	68	theme	TFR	297:299	arg1	time					351:354	contact time	343:354	contact time	343:354	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	68	theme	TFR	297:299	arg1	dosage					301:306	TFR dosage	297:306	TFR dosage	297:306	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	68	theme	TFR	297:299	arg1	temperature					357:367	temperature	357:367	temperature	357:367	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	68	theme	TFR	297:299	arg1	pH					309:310	pH	309:310	pH	309:310	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	2	68	theme	TFR	297:299	arg1	presence					373:380	presence	373:380	presence	373:380	Various influencing factors, such as TFR dosage, pH, initial Cr(VI) concentration, contact time, temperature and presence of co-ions in the medium, were investigated.
32541112	8	69	dep	consisted	1359:1367	arg1	VI					1347:1348	VI	1347:1348	VI	1347:1348	The mechanism of Cr(VI) removal consisted first of reduction to Cr(III), which has a low toxicity, and then chelation onto AC-TFR-2 via ion exchange.
32172848	5	0	theme	basis	736:740	arg1	sets					742:745	B3LYP/6-31G (d) basis sets	720:745	B3LYP/6-31G (d) basis sets	720:745	In addition to study the computational calculation of MCC, and CEC by DFT/ B3LYP/6-31G (d) basis sets.
32172848	6	1	theme	magnetite	998:1006	arg1	sizes					985:989	the particles' sizes	970:989	the particles' sizes of the magnetite	970:1006	The results showed that, the sample that is magnetite free has a diamagnetic response to the applied magnetic field, however the other samples that is loaded with magnetite show super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm.
32172848	1	2	theme	Fe3O4	140:144	arg1	film					166:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film	101:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties	101:218	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties was successfully prepared.
32172848	3	3	theme	mass	337:340	arg1	fraction					342:349	magnetite mass fraction	327:349	magnetite mass fraction	327:349	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	4	4	theme	sample	500:505	arg1	VSM					521:523	VSM	521:523	VSM	521:523	The Vibrating sample magnetometer (VSM) and broadband dielectric spectrometer was also employed to study the magnetic and dielectric properties, respectively.
32172848	4	4	theme	sample	500:505	arg1	magnetometer					507:518	The Vibrating sample magnetometer	486:518	The Vibrating sample magnetometer (VSM)	486:524	The Vibrating sample magnetometer (VSM) and broadband dielectric spectrometer was also employed to study the magnetic and dielectric properties, respectively.
32172848	3	5	dep	morphology	358:367	arg1	the					354:356	the	354:356	the	354:356	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	2	6	theme	micro	277:281	arg1	cellulose					295:303	micro crystalline cellulose	277:303	micro crystalline cellulose (MCC)	277:309	CEC has been synthesized from micro crystalline cellulose (MCC).
32172848	2	6	theme	micro	277:281	arg1	MCC					306:308	MCC	306:308	MCC	306:308	CEC has been synthesized from micro crystalline cellulose (MCC).
32172848	1	7	theme	Cyanoethyl	101:110	arg1	film					166:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film	101:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties	101:218	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties was successfully prepared.
32172848	0	8	theme	semiconducting	80:93	arg1	film					95:98	semiconducting film	80:98	semiconducting film	80:98	In situ synthesis of Fe3O4@ cyanoethyl cellulose composite as antimicrobial and semiconducting film.
32172848	6	9	theme	magnetic	849:856	arg1	field					858:862	the applied magnetic field	837:862	the applied magnetic field	837:862	The results showed that, the sample that is magnetite free has a diamagnetic response to the applied magnetic field, however the other samples that is loaded with magnetite show super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm.
32172848	7	10	theme	films	1072:1076	arg1	activities					1048:1057	antimicrobial activities	1034:1057	antimicrobial activities of composite films against (G + ve), (G-ve),	1034:1102	Also, antimicrobial activities of composite films against (G + ve), (G-ve), were investigated.
32172848	6	11	theme	super-paramagnetic	926:943	arg1	behavior					945:952	super-paramagnetic behavior	926:952	super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm	926:1025	The results showed that, the sample that is magnetite free has a diamagnetic response to the applied magnetic field, however the other samples that is loaded with magnetite show super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm.
32172848	5	12	theme	B3LYP/6-31G	720:730	arg1	sets					742:745	B3LYP/6-31G (d) basis sets	720:745	B3LYP/6-31G (d) basis sets	720:745	In addition to study the computational calculation of MCC, and CEC by DFT/ B3LYP/6-31G (d) basis sets.
32172848	6	13	contain	has	807:809	arg2	response					825:832	a diamagnetic response	811:832	a diamagnetic response to the applied magnetic field	811:862	The results showed that, the sample that is magnetite free has a diamagnetic response to the applied magnetic field, however the other samples that is loaded with magnetite show super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm.
32172848	6	13	contain	has	807:809	arg1	free					802:805	free	802:805	free	802:805	The results showed that, the sample that is magnetite free has a diamagnetic response to the applied magnetic field, however the other samples that is loaded with magnetite show super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm.
32172848	6	13	contain	has	807:809	arg1	sample					777:782	the sample	773:782	the sample that is magnetite free	773:805	The results showed that, the sample that is magnetite free has a diamagnetic response to the applied magnetic field, however the other samples that is loaded with magnetite show super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm.
32172848	3	14	theme	composite	451:459	arg1	films					461:465	the as-prepared composite films	435:465	the as-prepared composite films	435:465	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	3	15	theme	antimicrobial	409:421	arg1	activity					423:430	antimicrobial activity	409:430	antimicrobial activity	409:430	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	3	16	theme	magnetite	327:335	arg1	fraction					342:349	magnetite mass fraction	327:349	magnetite mass fraction	327:349	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	6	17	dep	sizes	985:989	arg1	20 nm					1021:1025	20 nm	1021:1025	20 nm	1021:1025	The results showed that, the sample that is magnetite free has a diamagnetic response to the applied magnetic field, however the other samples that is loaded with magnetite show super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm.
32172848	3	18	theme	thermal	386:392	arg1	stability					394:402	thermal stability	386:402	thermal stability	386:402	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	5	19	dep	study	660:664	arg1	addition					648:655	addition	648:655	addition	648:655	In addition to study the computational calculation of MCC, and CEC by DFT/ B3LYP/6-31G (d) basis sets.
32172848	1	20	theme	flexible	147:154	arg1	film					166:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film	101:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties	101:218	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties was successfully prepared.
32172848	6	21	theme	applied	841:847	arg1	field					858:862	the applied magnetic field	837:862	the applied magnetic field	837:862	The results showed that, the sample that is magnetite free has a diamagnetic response to the applied magnetic field, however the other samples that is loaded with magnetite show super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm.
32172848	5	22	theme	computational	670:682	arg1	calculation					684:694	the computational calculation	666:694	the computational calculation of MCC, and CEC	666:710	In addition to study the computational calculation of MCC, and CEC by DFT/ B3LYP/6-31G (d) basis sets.
32172848	1	23	theme	composite	156:164	arg1	film					166:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film	101:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties	101:218	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties was successfully prepared.
32172848	0	24	theme	In	0:1	arg1	synthesis					8:16	In situ synthesis	0:16	In situ synthesis of Fe3O4@ cyanoethyl	0:37	In situ synthesis of Fe3O4@ cyanoethyl cellulose composite as antimicrobial and semiconducting film.
32172848	4	25	theme	dielectric	540:549	arg1	spectrometer					551:562	broadband dielectric spectrometer	530:562	broadband dielectric spectrometer	530:562	The Vibrating sample magnetometer (VSM) and broadband dielectric spectrometer was also employed to study the magnetic and dielectric properties, respectively.
32172848	7	26	theme	antimicrobial	1034:1046	arg1	activities					1048:1057	antimicrobial activities	1034:1057	antimicrobial activities of composite films against (G + ve), (G-ve),	1034:1102	Also, antimicrobial activities of composite films against (G + ve), (G-ve), were investigated.
32172848	4	27	theme	broadband	530:538	arg1	spectrometer					551:562	broadband dielectric spectrometer	530:562	broadband dielectric spectrometer	530:562	The Vibrating sample magnetometer (VSM) and broadband dielectric spectrometer was also employed to study the magnetic and dielectric properties, respectively.
32172848	5	28	theme	MCC	699:701	arg1	calculation					684:694	the computational calculation	666:694	the computational calculation of MCC, and CEC	666:710	In addition to study the computational calculation of MCC, and CEC by DFT/ B3LYP/6-31G (d) basis sets.
32172848	3	29	theme	as-prepared	439:449	arg1	films					461:465	the as-prepared composite films	435:465	the as-prepared composite films	435:465	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	4	30	theme	magnetic	595:602	arg1	properties					619:628	the magnetic and dielectric properties	591:628	the magnetic and dielectric properties	591:628	The Vibrating sample magnetometer (VSM) and broadband dielectric spectrometer was also employed to study the magnetic and dielectric properties, respectively.
32172848	2	31	theme	crystalline	283:293	arg1	cellulose					295:303	micro crystalline cellulose	277:303	micro crystalline cellulose (MCC)	277:309	CEC has been synthesized from micro crystalline cellulose (MCC).
32172848	2	31	theme	crystalline	283:293	arg1	MCC					306:308	MCC	306:308	MCC	306:308	CEC has been synthesized from micro crystalline cellulose (MCC).
32172848	1	32	theme	enhanced	176:183	arg1	properties					209:218	enhanced dielectric and magnetic properties	176:218	enhanced dielectric and magnetic properties	176:218	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties was successfully prepared.
32172848	0	33	theme	@	26:26	arg1	cyanoethyl					28:37	Fe3O4@ cyanoethyl	21:37	Fe3O4@ cyanoethyl	21:37	In situ synthesis of Fe3O4@ cyanoethyl cellulose composite as antimicrobial and semiconducting film.
32172848	6	34	theme	diamagnetic	813:823	arg1	response					825:832	a diamagnetic response	811:832	a diamagnetic response to the applied magnetic field	811:862	The results showed that, the sample that is magnetite free has a diamagnetic response to the applied magnetic field, however the other samples that is loaded with magnetite show super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm.
32172848	1	35	theme	dielectric	185:194	arg1	properties					209:218	enhanced dielectric and magnetic properties	176:218	enhanced dielectric and magnetic properties	176:218	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties was successfully prepared.
32172848	0	36	theme	Fe3O4	21:25	arg1	cyanoethyl					28:37	Fe3O4@ cyanoethyl	21:37	Fe3O4@ cyanoethyl	21:37	In situ synthesis of Fe3O4@ cyanoethyl cellulose composite as antimicrobial and semiconducting film.
32172848	5	37	theme	CEC	708:710	arg1	calculation					684:694	the computational calculation	666:694	the computational calculation of MCC, and CEC	666:710	In addition to study the computational calculation of MCC, and CEC by DFT/ B3LYP/6-31G (d) basis sets.
32172848	6	38	dep	has	807:809	arg1	show					921:924	show	921:924	show super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm	921:1025	The results showed that, the sample that is magnetite free has a diamagnetic response to the applied magnetic field, however the other samples that is loaded with magnetite show super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm.
32172848	1	39	theme	cellulose	112:120	arg1	film					166:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film	101:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties	101:218	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties was successfully prepared.
32172848	0	40	theme	cyanoethyl	28:37	arg1	synthesis					8:16	In situ synthesis	0:16	In situ synthesis of Fe3O4@ cyanoethyl	0:37	In situ synthesis of Fe3O4@ cyanoethyl cellulose composite as antimicrobial and semiconducting film.
32172848	6	41	dep	indicating	954:963	arg1	sizes					985:989	the particles' sizes	970:989	the particles' sizes of the magnetite	970:1006	The results showed that, the sample that is magnetite free has a diamagnetic response to the applied magnetic field, however the other samples that is loaded with magnetite show super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm.
32172848	1	42	with	film	166:169	arg1	properties					209:218	enhanced dielectric and magnetic properties	176:218	enhanced dielectric and magnetic properties	176:218	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties was successfully prepared.
32172848	7	43	theme	composite	1062:1070	arg1	films					1072:1076	composite films	1062:1076	composite films against (G + ve), (G-ve),	1062:1102	Also, antimicrobial activities of composite films against (G + ve), (G-ve), were investigated.
32172848	6	44	theme	other	877:881	arg1	samples					883:889	the other samples	873:889	the other samples that is loaded with magnetite	873:919	The results showed that, the sample that is magnetite free has a diamagnetic response to the applied magnetic field, however the other samples that is loaded with magnetite show super-paramagnetic behavior indicating that the particles' sizes of the magnetite mostly below 20 nm.
32172848	3	45	theme	films	461:465	arg1	morphology					358:367	morphology	358:367	morphology	358:367	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	3	45	theme	films	461:465	arg1	activity					423:430	antimicrobial activity	409:430	antimicrobial activity	409:430	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	3	45	theme	films	461:465	arg1	microstructure					370:383	microstructure	370:383	microstructure	370:383	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	3	45	theme	films	461:465	arg1	stability					394:402	thermal stability	386:402	thermal stability	386:402	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	1	46	theme	magnetic	200:207	arg1	properties					209:218	enhanced dielectric and magnetic properties	176:218	enhanced dielectric and magnetic properties	176:218	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties was successfully prepared.
32172848	1	47	theme	CEC	123:125	arg1	film					166:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film	101:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties	101:218	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties was successfully prepared.
32172848	5	48	theme	d	733:733	arg1	sets					742:745	B3LYP/6-31G (d) basis sets	720:745	B3LYP/6-31G (d) basis sets	720:745	In addition to study the computational calculation of MCC, and CEC by DFT/ B3LYP/6-31G (d) basis sets.
32172848	3	49	from	effects	316:322	arg1	morphology					358:367	morphology	358:367	morphology	358:367	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	3	49	from	effects	316:322	arg1	activity					423:430	antimicrobial activity	409:430	antimicrobial activity	409:430	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	3	49	from	effects	316:322	arg1	microstructure					370:383	microstructure	370:383	microstructure	370:383	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	3	49	from	effects	316:322	arg1	stability					394:402	thermal stability	386:402	thermal stability	386:402	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32172848	4	50	theme	dielectric	608:617	arg1	properties					619:628	the magnetic and dielectric properties	591:628	the magnetic and dielectric properties	591:628	The Vibrating sample magnetometer (VSM) and broadband dielectric spectrometer was also employed to study the magnetic and dielectric properties, respectively.
32172848	4	51	theme	Vibrating	490:498	arg1	VSM					521:523	VSM	521:523	VSM	521:523	The Vibrating sample magnetometer (VSM) and broadband dielectric spectrometer was also employed to study the magnetic and dielectric properties, respectively.
32172848	4	51	theme	Vibrating	490:498	arg1	magnetometer					507:518	The Vibrating sample magnetometer	486:518	The Vibrating sample magnetometer (VSM)	486:524	The Vibrating sample magnetometer (VSM) and broadband dielectric spectrometer was also employed to study the magnetic and dielectric properties, respectively.
32172848	0	52	dep	In	0:1	arg1	situ					3:6	situ	3:6	situ	3:6	In situ synthesis of Fe3O4@ cyanoethyl cellulose composite as antimicrobial and semiconducting film.
32172848	1	53	theme	magnetite	129:137	arg1	film					166:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film	101:169	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties	101:218	Cyanoethyl cellulose (CEC)/ magnetite (Fe3O4) flexible composite film with enhanced dielectric and magnetic properties was successfully prepared.
32172848	3	54	theme	fraction	342:349	arg1	effects					316:322	The effects	312:322	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films	312:465	The effects of magnetite mass fraction on the morphology, microstructure, thermal stability, and antimicrobial activity of the as-prepared composite films were investigated.
32475561	6	0	theme	scavenging	1005:1014	arg1	activities					1016:1025	radical scavenging activities	997:1025	radical scavenging activities	997:1025	Besides, the Cur-loaded core-shell nanocomposite also showed higher antioxidant and radical scavenging activities than Cur.
32475561	6	1	theme	radical	997:1003	arg1	activities					1016:1025	radical scavenging activities	997:1025	radical scavenging activities	997:1025	Besides, the Cur-loaded core-shell nanocomposite also showed higher antioxidant and radical scavenging activities than Cur.
32475561	2	2	theme	novel	302:306	arg1	nanocomposite					319:331	a novel core-shell nanocomposite	300:331	a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery	300:442	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	1	3	dep	green	182:186	arg1	materials					204:212	materials	204:212	materials	204:212	Nanocomposites from plant-derived polysaccharides and proteins are green and sustainable materials that can be applied in various food and biomedical fields.
32475561	1	3	dep	green	182:186	arg1	Nanocomposites					115:128	Nanocomposites	115:128	Nanocomposites from plant-derived polysaccharides and proteins	115:176	Nanocomposites from plant-derived polysaccharides and proteins are green and sustainable materials that can be applied in various food and biomedical fields.
32475561	4	4	theme	electrostatic	698:710	arg1	interactions					712:723	electrostatic interactions	698:723	electrostatic interactions	698:723	Furthermore, the interactions between CMCFG and PP-Cur in the complexes were enhanced at pH 3.5 by electrostatic interactions.
32475561	5	5	with	performance	791:801	arg1	chemical					881:888	chemical	881:888	chemical	881:888	The resulting nanocomposite exhibited an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability.
32475561	5	5	with	performance	791:801	arg1	efficiency					833:842	high Cur loading efficiency	816:842	high Cur loading efficiency	816:842	The resulting nanocomposite exhibited an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability.
32475561	5	5	with	performance	791:801	arg1	dispersibility					856:869	good water dispersibility	845:869	good water dispersibility	845:869	The resulting nanocomposite exhibited an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability.
32475561	3	6	theme	PP-Cur	465:470	arg1	complexes					472:480	PP-Cur complexes	465:480	PP-Cur complexes (PP-Cur)	465:489	In the preparation, PP-Cur complexes (PP-Cur) were formed at pH 7.0 and then coated by CMCFG via hydrophobic interactions to form PP-Cur-CMCFG complexes.
32475561	3	6	theme	PP-Cur	465:470	arg1	PP-Cur					483:488	PP-Cur	483:488	PP-Cur	483:488	In the preparation, PP-Cur complexes (PP-Cur) were formed at pH 7.0 and then coated by CMCFG via hydrophobic interactions to form PP-Cur-CMCFG complexes.
32475561	5	7	theme	thermal	894:900	arg1	stability					902:910	high chemical and thermal stability	876:910	stability	902:910	The resulting nanocomposite exhibited an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability.
32475561	7	8	theme	systems	1103:1109	arg1	use					1073:1075	the use	1069:1075	the use of plant-derived delivery systems as a strategy for the delivery of chemically unstable hydrophobic Cur	1069:1179	Our results provide support for the use of plant-derived delivery systems as a strategy for the delivery of chemically unstable hydrophobic Cur.
32475561	2	9	from	gum	367:369	arg1	nanocomposite					319:331	a novel core-shell nanocomposite	300:331	a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery	300:442	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	5	10	theme	good	845:848	arg1	dispersibility					856:869	good water dispersibility	845:869	good water dispersibility	845:869	The resulting nanocomposite exhibited an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability.
32475561	5	11	theme	water	850:854	arg1	dispersibility					856:869	good water dispersibility	845:869	good water dispersibility	845:869	The resulting nanocomposite exhibited an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability.
32475561	0	12	theme	pea	11:13	arg1	composite					56:64	Core-shell pea protein-carboxymethylated corn fiber gum composite	0:64	Core-shell pea protein-carboxymethylated corn fiber gum composite	0:64	Core-shell pea protein-carboxymethylated corn fiber gum composite nanoparticles as delivery vehicles for curcumin.
32475561	7	13	theme	plant-derived	1080:1092	arg1	systems					1103:1109	plant-derived delivery systems	1080:1109	plant-derived delivery systems	1080:1109	Our results provide support for the use of plant-derived delivery systems as a strategy for the delivery of chemically unstable hydrophobic Cur.
32475561	1	14	from	proteins	169:176	arg1	materials					204:212	materials	204:212	materials	204:212	Nanocomposites from plant-derived polysaccharides and proteins are green and sustainable materials that can be applied in various food and biomedical fields.
32475561	1	14	from	proteins	169:176	arg1	Nanocomposites					115:128	Nanocomposites	115:128	Nanocomposites from plant-derived polysaccharides and proteins	115:176	Nanocomposites from plant-derived polysaccharides and proteins are green and sustainable materials that can be applied in various food and biomedical fields.
32475561	2	15	theme	carboxymethylated	338:354	arg1	gum					367:369	carboxymethylated corn fiber gum	338:369	carboxymethylated corn fiber gum (CMCFG)	338:377	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	2	15	theme	carboxymethylated	338:354	arg1	CMCFG					372:376	CMCFG	372:376	CMCFG	372:376	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	2	16	theme	pea	399:401	arg1	protein					403:409	high nutritious pea protein	383:409	high nutritious pea protein (PP)	383:414	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	2	16	theme	pea	399:401	arg1	PP					412:413	PP	412:413	PP	412:413	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	0	17	theme	Core-shell	0:9	arg1	composite					56:64	Core-shell pea protein-carboxymethylated corn fiber gum composite	0:64	Core-shell pea protein-carboxymethylated corn fiber gum composite	0:64	Core-shell pea protein-carboxymethylated corn fiber gum composite nanoparticles as delivery vehicles for curcumin.
32475561	6	18	theme	higher	974:979	arg1	antioxidant					981:991	higher antioxidant	974:991	higher antioxidant	974:991	Besides, the Cur-loaded core-shell nanocomposite also showed higher antioxidant and radical scavenging activities than Cur.
32475561	7	19	theme	delivery	1094:1101	arg1	systems					1103:1109	plant-derived delivery systems	1080:1109	plant-derived delivery systems	1080:1109	Our results provide support for the use of plant-derived delivery systems as a strategy for the delivery of chemically unstable hydrophobic Cur.
32475561	4	20	from	interactions	616:627	arg1	complexes					661:669	the complexes	657:669	the complexes	657:669	Furthermore, the interactions between CMCFG and PP-Cur in the complexes were enhanced at pH 3.5 by electrostatic interactions.
32475561	2	21	theme	nutritious	388:397	arg1	protein					403:409	high nutritious pea protein	383:409	high nutritious pea protein (PP)	383:414	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	2	21	theme	nutritious	388:397	arg1	PP					412:413	PP	412:413	PP	412:413	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	0	22	theme	corn	41:44	arg1	composite					56:64	Core-shell pea protein-carboxymethylated corn fiber gum composite	0:64	Core-shell pea protein-carboxymethylated corn fiber gum composite	0:64	Core-shell pea protein-carboxymethylated corn fiber gum composite nanoparticles as delivery vehicles for curcumin.
32475561	1	23	from	polysaccharides	149:163	arg1	materials					204:212	materials	204:212	materials	204:212	Nanocomposites from plant-derived polysaccharides and proteins are green and sustainable materials that can be applied in various food and biomedical fields.
32475561	1	23	from	polysaccharides	149:163	arg1	Nanocomposites					115:128	Nanocomposites	115:128	Nanocomposites from plant-derived polysaccharides and proteins	115:176	Nanocomposites from plant-derived polysaccharides and proteins are green and sustainable materials that can be applied in various food and biomedical fields.
32475561	2	24	theme	curcumin	420:427	arg1	delivery					435:442	curcumin (Cur) delivery	420:442	curcumin (Cur) delivery	420:442	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	0	25	theme	protein-carboxymethylated	15:39	arg1	composite					56:64	Core-shell pea protein-carboxymethylated corn fiber gum composite	0:64	Core-shell pea protein-carboxymethylated corn fiber gum composite	0:64	Core-shell pea protein-carboxymethylated corn fiber gum composite nanoparticles as delivery vehicles for curcumin.
32475561	2	26	theme	core-shell	308:317	arg1	nanocomposite					319:331	a novel core-shell nanocomposite	300:331	a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery	300:442	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	7	27	theme	unstable	1156:1163	arg1	Cur					1177:1179	chemically unstable hydrophobic Cur	1145:1179	chemically unstable hydrophobic Cur	1145:1179	Our results provide support for the use of plant-derived delivery systems as a strategy for the delivery of chemically unstable hydrophobic Cur.
32475561	5	28	theme	loading	825:831	arg1	efficiency					833:842	high Cur loading efficiency	816:842	high Cur loading efficiency	816:842	The resulting nanocomposite exhibited an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability.
32475561	0	29	theme	gum	52:54	arg1	composite					56:64	Core-shell pea protein-carboxymethylated corn fiber gum composite	0:64	Core-shell pea protein-carboxymethylated corn fiber gum composite	0:64	Core-shell pea protein-carboxymethylated corn fiber gum composite nanoparticles as delivery vehicles for curcumin.
32475561	7	30	link	plant-derived	1080:1092	arg1	systems					1103:1109	plant-derived delivery systems	1080:1109	plant-derived delivery systems	1080:1109	Our results provide support for the use of plant-derived delivery systems as a strategy for the delivery of chemically unstable hydrophobic Cur.
32475561	1	31	theme	various	237:243	arg1	fields					265:270	various food and biomedical fields	237:270	various food and biomedical fields	237:270	Nanocomposites from plant-derived polysaccharides and proteins are green and sustainable materials that can be applied in various food and biomedical fields.
32475561	0	32	theme	fiber	46:50	arg1	composite					56:64	Core-shell pea protein-carboxymethylated corn fiber gum composite	0:64	Core-shell pea protein-carboxymethylated corn fiber gum composite	0:64	Core-shell pea protein-carboxymethylated corn fiber gum composite nanoparticles as delivery vehicles for curcumin.
32475561	6	33	theme	core-shell	937:946	arg1	nanocomposite					948:960	the Cur-loaded core-shell nanocomposite	922:960	the Cur-loaded core-shell nanocomposite	922:960	Besides, the Cur-loaded core-shell nanocomposite also showed higher antioxidant and radical scavenging activities than Cur.
32475561	5	34	theme	excellent	767:775	arg1	performance					791:801	an excellent encapsulation performance	764:801	an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability	764:910	The resulting nanocomposite exhibited an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability.
32475561	7	35	theme	hydrophobic	1165:1175	arg1	Cur					1177:1179	chemically unstable hydrophobic Cur	1145:1179	chemically unstable hydrophobic Cur	1145:1179	Our results provide support for the use of plant-derived delivery systems as a strategy for the delivery of chemically unstable hydrophobic Cur.
32475561	1	36	theme	food	245:248	arg1	fields					265:270	various food and biomedical fields	237:270	various food and biomedical fields	237:270	Nanocomposites from plant-derived polysaccharides and proteins are green and sustainable materials that can be applied in various food and biomedical fields.
32475561	5	37	theme	encapsulation	777:789	arg1	performance					791:801	an excellent encapsulation performance	764:801	an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability	764:910	The resulting nanocomposite exhibited an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability.
32475561	6	38	theme	Cur-loaded	926:935	arg1	nanocomposite					948:960	the Cur-loaded core-shell nanocomposite	922:960	the Cur-loaded core-shell nanocomposite	922:960	Besides, the Cur-loaded core-shell nanocomposite also showed higher antioxidant and radical scavenging activities than Cur.
32475561	1	39	theme	plant-derived	135:147	arg1	polysaccharides					149:163	plant-derived polysaccharides	135:163	plant-derived polysaccharides	135:163	Nanocomposites from plant-derived polysaccharides and proteins are green and sustainable materials that can be applied in various food and biomedical fields.
32475561	3	40	theme	hydrophobic	542:552	arg1	interactions					554:565	hydrophobic interactions	542:565	hydrophobic interactions	542:565	In the preparation, PP-Cur complexes (PP-Cur) were formed at pH 7.0 and then coated by CMCFG via hydrophobic interactions to form PP-Cur-CMCFG complexes.
32475561	1	41	link	plant-derived	135:147	arg1	polysaccharides					149:163	plant-derived polysaccharides	135:163	plant-derived polysaccharides	135:163	Nanocomposites from plant-derived polysaccharides and proteins are green and sustainable materials that can be applied in various food and biomedical fields.
32475561	2	42	from	protein	403:409	arg1	nanocomposite					319:331	a novel core-shell nanocomposite	300:331	a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery	300:442	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	2	43	theme	fiber	361:365	arg1	gum					367:369	carboxymethylated corn fiber gum	338:369	carboxymethylated corn fiber gum (CMCFG)	338:377	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	2	43	theme	fiber	361:365	arg1	CMCFG					372:376	CMCFG	372:376	CMCFG	372:376	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	5	44	theme	high	816:819	arg1	efficiency					833:842	high Cur loading efficiency	816:842	high Cur loading efficiency	816:842	The resulting nanocomposite exhibited an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability.
32475561	2	45	theme	corn	356:359	arg1	gum					367:369	carboxymethylated corn fiber gum	338:369	carboxymethylated corn fiber gum (CMCFG)	338:377	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	2	45	theme	corn	356:359	arg1	CMCFG					372:376	CMCFG	372:376	CMCFG	372:376	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	1	46	theme	biomedical	254:263	arg1	fields					265:270	various food and biomedical fields	237:270	various food and biomedical fields	237:270	Nanocomposites from plant-derived polysaccharides and proteins are green and sustainable materials that can be applied in various food and biomedical fields.
32475561	0	47	theme	delivery	83:90	arg1	vehicles					92:99	delivery vehicles	83:99	delivery vehicles for curcumin	83:112	Core-shell pea protein-carboxymethylated corn fiber gum composite nanoparticles as delivery vehicles for curcumin.
32475561	5	48	theme	Cur	821:823	arg1	efficiency					833:842	high Cur loading efficiency	816:842	high Cur loading efficiency	816:842	The resulting nanocomposite exhibited an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability.
32475561	2	49	theme	high	383:386	arg1	protein					403:409	high nutritious pea protein	383:409	high nutritious pea protein (PP)	383:414	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	2	49	theme	high	383:386	arg1	PP					412:413	PP	412:413	PP	412:413	In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery.
32475561	5	50	theme	resulting	730:738	arg1	nanocomposite					740:752	The resulting nanocomposite	726:752	The resulting nanocomposite	726:752	The resulting nanocomposite exhibited an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability.
32475561	3	51	theme	PP-Cur-CMCFG	575:586	arg1	complexes					588:596	PP-Cur-CMCFG complexes	575:596	PP-Cur-CMCFG complexes	575:596	In the preparation, PP-Cur complexes (PP-Cur) were formed at pH 7.0 and then coated by CMCFG via hydrophobic interactions to form PP-Cur-CMCFG complexes.
32475561	7	52	theme	Cur	1177:1179	arg1	delivery					1133:1140	the delivery	1129:1140	the delivery of chemically unstable hydrophobic Cur	1129:1179	Our results provide support for the use of plant-derived delivery systems as a strategy for the delivery of chemically unstable hydrophobic Cur.
32475565	3	0	dep	red	539:541	arg1	to					536:537	to	536:537	to	536:537	Notably, the CNC-S film exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %.
32475565	5	1	theme	functional	831:840	arg1	film					809:812	the CNC-S composite film	789:812	the CNC-S composite film	789:812	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	5	1	theme	functional	831:840	arg1	material					842:849	a functional material	829:849	a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields	829:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	5	2	theme	CNC-S	793:797	arg1	film					809:812	the CNC-S composite film	789:812	the CNC-S composite film	789:812	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	5	2	theme	CNC-S	793:797	arg1	material					842:849	a functional material	829:849	a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields	829:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	5	3	from	industry	968:975	arg1	detection					908:916	the detection	904:916	the detection of environmental humidity changes in agriculture, industry, and other fields	904:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	4	4	theme	good	680:683	arg1	reversibility					685:697	good reversibility	680:697	good reversibility (>10 cycles)	680:710	Moreover, it was found that the composite films had a large colour-change range, good reversibility (>10 cycles), and excellent stability (>10 weeks).
32475565	4	4	theme	good	680:683	arg1	cycles					704:709	>10 cycles	700:709	>10 cycles	700:709	Moreover, it was found that the composite films had a large colour-change range, good reversibility (>10 cycles), and excellent stability (>10 weeks).
32475565	3	5	from	light	524:528	arg1	changes					511:517	obvious reversible colour changes	485:517	obvious reversible colour changes from light green to red upon a relative humidity (RH)	485:571	Notably, the CNC-S film exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %.
32475565	4	6	theme	large	653:657	arg1	range					673:677	a large colour-change range	651:677	a large colour-change range	651:677	Moreover, it was found that the composite films had a large colour-change range, good reversibility (>10 cycles), and excellent stability (>10 weeks).
32475565	2	7	with	effects	277:283	arg1	weights					321:327	different molecular weights	301:327	different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films	301:430	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	5	8	from	agriculture	955:965	arg1	detection					908:916	the detection	904:916	the detection of environmental humidity changes in agriculture, industry, and other fields	904:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	2	9	theme	molecular	311:319	arg1	weights					321:327	different molecular weights	301:327	different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films	301:430	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	2	10	dep	structure	336:344	arg1	the					332:334	the	332:334	the	332:334	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	5	11	theme	other	982:986	arg1	fields					988:993	other fields	982:993	other fields	982:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	2	12	theme	composite	416:424	arg1	films					426:430	the composite films	412:430	the composite films	412:430	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	2	13	from	weights	321:327	arg1	properties					355:364	optical properties	347:364	optical properties	347:364	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	2	13	from	weights	321:327	arg1	strength					378:385	mechanical strength	367:385	mechanical strength	367:385	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	2	13	from	weights	321:327	arg1	response					400:407	humidity response	391:407	humidity response	391:407	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	2	13	from	weights	321:327	arg1	structure					336:344	structure	336:344	structure	336:344	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	3	14	theme	red	539:541	arg1	light					524:528	light	524:528	light green to red	524:541	Notably, the CNC-S film exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %.
32475565	4	15	contain	had	647:649	arg2	stability					727:735	excellent stability	717:735	excellent stability (>10 weeks)	717:747	Moreover, it was found that the composite films had a large colour-change range, good reversibility (>10 cycles), and excellent stability (>10 weeks).
32475565	4	15	contain	had	647:649	arg1	films					641:645	the composite films	627:645	the composite films	627:645	Moreover, it was found that the composite films had a large colour-change range, good reversibility (>10 cycles), and excellent stability (>10 weeks).
32475565	4	15	contain	had	647:649	arg2	range					673:677	a large colour-change range	651:677	a large colour-change range	651:677	Moreover, it was found that the composite films had a large colour-change range, good reversibility (>10 cycles), and excellent stability (>10 weeks).
32475565	4	15	contain	had	647:649	arg2	cycles					704:709	>10 cycles	700:709	>10 cycles	700:709	Moreover, it was found that the composite films had a large colour-change range, good reversibility (>10 cycles), and excellent stability (>10 weeks).
32475565	4	15	contain	had	647:649	arg2	weeks					742:746	>10 weeks	738:746	>10 weeks	738:746	Moreover, it was found that the composite films had a large colour-change range, good reversibility (>10 cycles), and excellent stability (>10 weeks).
32475565	4	15	contain	had	647:649	arg2	reversibility					685:697	good reversibility	680:697	good reversibility (>10 cycles)	680:710	Moreover, it was found that the composite films had a large colour-change range, good reversibility (>10 cycles), and excellent stability (>10 weeks).
32475565	2	16	theme	optical	347:353	arg1	properties					355:364	optical properties	347:364	optical properties	347:364	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	3	17	dep	exhibited	475:483	arg1	change					573:578	change	573:578	exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %	475:596	Notably, the CNC-S film exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %.
32475565	5	18	from	detection	908:916	arg1	fields					988:993	other fields	982:993	other fields	982:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	5	18	from	detection	908:916	arg1	industry					968:975	industry	968:975	industry	968:975	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	5	18	from	detection	908:916	arg1	agriculture					955:965	agriculture	955:965	agriculture	955:965	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	5	19	used	used	821:824	arg2	film					809:812	the CNC-S composite film	789:812	the CNC-S composite film	789:812	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	5	19	used	used	821:824	arg2	material					842:849	a functional material	829:849	a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields	829:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	0	20	theme	humidity-responsive	29:47	arg1	films					60:64	environmental humidity-responsive iridescent films	15:64	environmental humidity-responsive iridescent films	15:64	Fabrication of environmental humidity-responsive iridescent films with cellulose nanocrystal/polyols.
32475565	5	21	theme	composite	799:807	arg1	film					809:812	the CNC-S composite film	789:812	the CNC-S composite film	789:812	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	5	21	theme	composite	799:807	arg1	material					842:849	a functional material	829:849	a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields	829:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	1	22	theme	flexible	124:131	arg1	films					166:170	flexible and humidity-sensitive composite films	124:170	flexible and humidity-sensitive composite films	124:170	Herein, we fabricated flexible and humidity-sensitive composite films employing cellulose nanocrystal (CNC) and polyols, i.e., glycerol (G), xylitol (X) and sorbitol (S).
32475565	2	23	theme	humidity	391:398	arg1	response					400:407	humidity response	391:407	humidity response	391:407	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	0	24	theme	environmental	15:27	arg1	films					60:64	environmental humidity-responsive iridescent films	15:64	environmental humidity-responsive iridescent films	15:64	Fabrication of environmental humidity-responsive iridescent films with cellulose nanocrystal/polyols.
32475565	3	25	theme	colour	504:509	arg1	changes					511:517	obvious reversible colour changes	485:517	obvious reversible colour changes from light green to red upon a relative humidity (RH)	485:571	Notably, the CNC-S film exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %.
32475565	3	26	theme	CNC-S	464:468	arg1	film					470:473	the CNC-S film	460:473	the CNC-S film	460:473	Notably, the CNC-S film exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %.
32475565	3	27	theme	obvious	485:491	arg1	changes					511:517	obvious reversible colour changes	485:517	obvious reversible colour changes from light green to red upon a relative humidity (RH)	485:571	Notably, the CNC-S film exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %.
32475565	0	28	theme	films	60:64	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of environmental humidity-responsive iridescent films with cellulose nanocrystal/polyols.	0:100	Fabrication of environmental humidity-responsive iridescent films with cellulose nanocrystal/polyols.
32475565	2	29	theme	different	301:309	arg1	weights					321:327	different molecular weights	301:327	different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films	301:430	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	3	30	theme	95	593:594	arg1	%					588:588	%	588:588	%	588:588	Notably, the CNC-S film exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %.
32475565	4	31	theme	excellent	717:725	arg1	stability					727:735	excellent stability	717:735	excellent stability (>10 weeks)	717:747	Moreover, it was found that the composite films had a large colour-change range, good reversibility (>10 cycles), and excellent stability (>10 weeks).
32475565	4	31	theme	excellent	717:725	arg1	weeks					742:746	>10 weeks	738:746	>10 weeks	738:746	Moreover, it was found that the composite films had a large colour-change range, good reversibility (>10 cycles), and excellent stability (>10 weeks).
32475565	0	32	theme	iridescent	49:58	arg1	films					60:64	environmental humidity-responsive iridescent films	15:64	environmental humidity-responsive iridescent films	15:64	Fabrication of environmental humidity-responsive iridescent films with cellulose nanocrystal/polyols.
32475565	3	33	theme	30	585:586	arg1	%					588:588	%	588:588	%	588:588	Notably, the CNC-S film exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %.
32475565	2	34	theme	mechanical	367:376	arg1	strength					378:385	mechanical strength	367:385	mechanical strength	367:385	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	0	35	theme	cellulose	71:79	arg1	nanocrystal/polyols					81:99	cellulose nanocrystal/polyols	71:99	cellulose nanocrystal/polyols	71:99	Fabrication of environmental humidity-responsive iridescent films with cellulose nanocrystal/polyols.
32475565	1	36	theme	humidity-sensitive	137:154	arg1	films					166:170	flexible and humidity-sensitive composite films	124:170	flexible and humidity-sensitive composite films	124:170	Herein, we fabricated flexible and humidity-sensitive composite films employing cellulose nanocrystal (CNC) and polyols, i.e., glycerol (G), xylitol (X) and sorbitol (S).
32475565	2	37	theme	films	426:430	arg1	properties					355:364	optical properties	347:364	optical properties	347:364	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	2	37	theme	films	426:430	arg1	strength					378:385	mechanical strength	367:385	mechanical strength	367:385	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	2	37	theme	films	426:430	arg1	response					400:407	humidity response	391:407	humidity response	391:407	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	2	37	theme	films	426:430	arg1	structure					336:344	structure	336:344	structure	336:344	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	5	38	theme	environmental	921:933	arg1	changes					944:950	environmental humidity changes	921:950	environmental humidity changes in agriculture, industry, and other fields	921:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	3	39	theme	relative	550:557	arg1	humidity					559:566	a relative humidity	548:566	a relative humidity (RH)	548:571	Notably, the CNC-S film exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %.
32475565	3	39	theme	relative	550:557	arg1	RH					569:570	RH	569:570	RH	569:570	Notably, the CNC-S film exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %.
32475565	1	40	theme	composite	156:164	arg1	films					166:170	flexible and humidity-sensitive composite films	124:170	flexible and humidity-sensitive composite films	124:170	Herein, we fabricated flexible and humidity-sensitive composite films employing cellulose nanocrystal (CNC) and polyols, i.e., glycerol (G), xylitol (X) and sorbitol (S).
32475565	5	41	from	fields	988:993	arg1	detection					908:916	the detection	904:916	the detection of environmental humidity changes in agriculture, industry, and other fields	904:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	4	42	theme	composite	631:639	arg1	films					641:645	the composite films	627:645	the composite films	627:645	Moreover, it was found that the composite films had a large colour-change range, good reversibility (>10 cycles), and excellent stability (>10 weeks).
32475565	5	43	theme	humidity	935:942	arg1	changes					944:950	environmental humidity changes	921:950	environmental humidity changes in agriculture, industry, and other fields	921:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	1	44	dep	glycerol	229:236	arg1	i.e.					223:226	i.e.	223:226	i.e.	223:226	Herein, we fabricated flexible and humidity-sensitive composite films employing cellulose nanocrystal (CNC) and polyols, i.e., glycerol (G), xylitol (X) and sorbitol (S).
32475565	0	45	with	Fabrication	0:10	arg1	nanocrystal/polyols					81:99	cellulose nanocrystal/polyols	71:99	cellulose nanocrystal/polyols	71:99	Fabrication of environmental humidity-responsive iridescent films with cellulose nanocrystal/polyols.
32475565	5	46	theme	changes	944:950	arg1	detection					908:916	the detection	904:916	the detection of environmental humidity changes in agriculture, industry, and other fields	904:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	5	47	theme	flexible	874:881	arg1	sensors					892:898	flexible humidity sensors	874:898	flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields	874:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	4	48	theme	colour-change	659:671	arg1	range					673:677	a large colour-change range	651:677	a large colour-change range	651:677	Moreover, it was found that the composite films had a large colour-change range, good reversibility (>10 cycles), and excellent stability (>10 weeks).
32475565	2	49	theme	polyols	288:294	arg1	effects					277:283	The effects	273:283	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films	273:430	The effects of polyols with different molecular weights on the structure, optical properties, mechanical strength and humidity response of the composite films were investigated.
32475565	3	50	dep	%	588:588	arg1	to					590:591	to	590:591	to	590:591	Notably, the CNC-S film exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %.
32475565	5	51	from	changes	944:950	arg1	fields					988:993	other fields	982:993	other fields	982:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	5	51	from	changes	944:950	arg1	industry					968:975	industry	968:975	industry	968:975	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	5	51	from	changes	944:950	arg1	agriculture					955:965	agriculture	955:965	agriculture	955:965	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	5	52	theme	humidity	883:890	arg1	sensors					892:898	flexible humidity sensors	874:898	flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields	874:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	1	53	theme	cellulose	182:190	arg1	nanocrystal					192:202	cellulose nanocrystal	182:202	cellulose nanocrystal (CNC)	182:208	Herein, we fabricated flexible and humidity-sensitive composite films employing cellulose nanocrystal (CNC) and polyols, i.e., glycerol (G), xylitol (X) and sorbitol (S).
32475565	1	53	theme	cellulose	182:190	arg1	CNC					205:207	CNC	205:207	CNC	205:207	Herein, we fabricated flexible and humidity-sensitive composite films employing cellulose nanocrystal (CNC) and polyols, i.e., glycerol (G), xylitol (X) and sorbitol (S).
32475565	5	54	theme	sensors	892:898	arg1	preparation					859:869	the preparation	855:869	the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields	855:993	Overall, the results demonstrated that the CNC-S composite film can be used as a functional material for the preparation of flexible humidity sensors for the detection of environmental humidity changes in agriculture, industry, and other fields.
32475565	3	55	theme	reversible	493:502	arg1	changes					511:517	obvious reversible colour changes	485:517	obvious reversible colour changes from light green to red upon a relative humidity (RH)	485:571	Notably, the CNC-S film exhibited obvious reversible colour changes from light green to red upon a relative humidity (RH) change from 30 % to 95 %.
34923304	7	0	theme	adsorption	1301:1310	arg1	change					1279:1284	The standard Gibbs energy change SLo	1253:1288	The standard Gibbs energy change SLo of benzene adsorption	1253:1310	The standard Gibbs energy change SLo of benzene adsorption was found to depend linearly on the number of modifier molecules present but independent of modifier identity.
34923304	3	1	theme	energy	537:542	arg1	change					544:549	the Gibbs energy change	527:549	the Gibbs energy change of solute adsorption with respect to the modifier concentration	527:613	The linear dependence of the Gibbs energy change of solute adsorption with respect to the modifier concentration was assumed, and the model was fitted to the experimental results, with good agreement demonstrated between the experimental data and the model.
34923304	1	2	theme	forces	282:287	arg1	dependence					256:265	the concentration dependence	238:265	the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers	238:371	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	6	3	from	effects	1144:1150	arg1	behaviors					1191:1199	the retention behaviors	1177:1199	the retention behaviors	1177:1199	The effects of both contributions on the retention behaviors were enhanced for the solutes with aromatic groups.
34923304	6	4	theme	aromatic	1236:1243	arg1	groups					1245:1250	aromatic groups	1236:1250	aromatic groups	1236:1250	The effects of both contributions on the retention behaviors were enhanced for the solutes with aromatic groups.
34923304	3	5	theme	adsorption	561:570	arg1	change					544:549	the Gibbs energy change	527:549	the Gibbs energy change of solute adsorption with respect to the modifier concentration	527:613	The linear dependence of the Gibbs energy change of solute adsorption with respect to the modifier concentration was assumed, and the model was fitted to the experimental results, with good agreement demonstrated between the experimental data and the model.
34923304	4	6	theme	retention	882:890	arg1	factors					892:898	the retention factors	878:898	the retention factors resulting from a weakened solvophobic interaction and modifier competitive adsorption	878:984	Retention behaviors were inferred to be determined by two key dimensionless groups that represented the reductions in the retention factors resulting from a weakened solvophobic interaction and modifier competitive adsorption.
34923304	1	7	theme	theoretical	206:216	arg1	framework					218:226	a theoretical framework	204:226	a theoretical framework	204:226	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	4	8	theme	competitive	963:973	arg1	adsorption					975:984	modifier competitive adsorption	954:984	modifier competitive adsorption	954:984	Retention behaviors were inferred to be determined by two key dimensionless groups that represented the reductions in the retention factors resulting from a weakened solvophobic interaction and modifier competitive adsorption.
34923304	11	9	theme	carbon	1889:1894	arg1	number					1896:1901	the carbon number	1885:1901	the carbon number of modifier molecule	1885:1922	The results show that the standard Gibbs energy change SLo for the first-layer adsorption of modifiers changed linearly with the carbon number of modifier molecule.
34923304	4	10	theme	solvophobic	926:936	arg1	interaction					938:948	a weakened solvophobic interaction	915:948	a weakened solvophobic interaction	915:948	Retention behaviors were inferred to be determined by two key dimensionless groups that represented the reductions in the retention factors resulting from a weakened solvophobic interaction and modifier competitive adsorption.
34923304	11	11	theme	molecule	1915:1922	arg1	number					1896:1901	the carbon number	1885:1901	the carbon number of modifier molecule	1885:1922	The results show that the standard Gibbs energy change SLo for the first-layer adsorption of modifiers changed linearly with the carbon number of modifier molecule.
34923304	1	12	theme	behavior	134:141	arg1	dependence					103:112	the dependence	99:112	the dependence of solute retention behavior on modifier content	99:161	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	1	13	theme	modifier	146:153	arg1	content					155:161	modifier content	146:161	modifier content	146:161	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	7	14	theme	modifier	1404:1411	arg1	identity					1413:1420	modifier identity	1404:1420	modifier identity	1404:1420	The standard Gibbs energy change SLo of benzene adsorption was found to depend linearly on the number of modifier molecules present but independent of modifier identity.
34923304	11	15	theme	first-layer	1827:1837	arg1	adsorption					1839:1848	the first-layer adsorption	1823:1848	the first-layer adsorption of modifiers	1823:1861	The results show that the standard Gibbs energy change SLo for the first-layer adsorption of modifiers changed linearly with the carbon number of modifier molecule.
34923304	8	16	from	interactions	1523:1534	arg1	degree					1484:1489	the degree	1480:1489	the degree of reduction in the solvophobic interactions	1480:1534	For the solutes associated with hydrogen-bonding groups, the degree of reduction in the solvophobic interactions was considerably reduced.
34923304	1	17	theme	solvent	355:361	arg1	modifiers					363:371	solvent modifiers	355:371	solvent modifiers	355:371	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	7	18	theme	SLo	1286:1288	arg1	change					1279:1284	The standard Gibbs energy change SLo	1253:1288	The standard Gibbs energy change SLo of benzene adsorption	1253:1310	The standard Gibbs energy change SLo of benzene adsorption was found to depend linearly on the number of modifier molecules present but independent of modifier identity.
34923304	1	19	theme	liquid	181:186	arg1	chromatography					188:201	reversed-phase liquid chromatography	166:201	reversed-phase liquid chromatography	166:201	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	3	20	theme	experimental	660:671	arg1	results					673:679	the experimental results	656:679	the experimental results	656:679	The linear dependence of the Gibbs energy change of solute adsorption with respect to the modifier concentration was assumed, and the model was fitted to the experimental results, with good agreement demonstrated between the experimental data and the model.
34923304	7	21	theme	energy	1272:1277	arg1	change					1279:1284	The standard Gibbs energy change SLo	1253:1288	The standard Gibbs energy change SLo of benzene adsorption	1253:1310	The standard Gibbs energy change SLo of benzene adsorption was found to depend linearly on the number of modifier molecules present but independent of modifier identity.
34923304	2	22	theme	model	420:424	arg1	generality					392:401	The generality	388:401	The generality of the developed model	388:424	The generality of the developed model was demonstrated by comparing the model with conventional retention models.
34923304	7	23	theme	standard	1257:1264	arg1	change					1279:1284	The standard Gibbs energy change SLo	1253:1288	The standard Gibbs energy change SLo of benzene adsorption	1253:1310	The standard Gibbs energy change SLo of benzene adsorption was found to depend linearly on the number of modifier molecules present but independent of modifier identity.
34923304	2	24	theme	conventional	471:482	arg1	models					494:499	conventional retention models	471:499	conventional retention models	471:499	The generality of the developed model was demonstrated by comparing the model with conventional retention models.
34923304	0	25	from	mechanisms	34:43	arg1	chromatography					70:83	reversed-phase liquid chromatography	48:83	reversed-phase liquid chromatography	48:83	Retention modeling and adsorption mechanisms in reversed-phase liquid chromatography.
34923304	4	26	theme	Retention	760:768	arg1	behaviors					770:778	Retention behaviors	760:778	Retention behaviors	760:778	Retention behaviors were inferred to be determined by two key dimensionless groups that represented the reductions in the retention factors resulting from a weakened solvophobic interaction and modifier competitive adsorption.
34923304	10	27	theme	adsorption	1737:1746	arg1	mechanisms					1748:1757	the modifier adsorption mechanisms	1724:1757	the modifier adsorption mechanisms	1724:1757	Perturbation method was performed to investigate the modifier adsorption mechanisms.
34923304	0	28	theme	Retention	0:8	arg1	modeling					10:17	Retention modeling	0:17	Retention modeling	0:17	Retention modeling and adsorption mechanisms in reversed-phase liquid chromatography.
34923304	12	29	theme	quantitative	2010:2021	arg1	description					2023:2033	a physically consistent quantitative description	1986:2033	a physically consistent quantitative description of retention	1986:2046	These results demonstrated that the proposed model can offer a physically consistent quantitative description of retention when solvent composition is varied.
34923304	5	30	theme	retention	991:999	arg1	behaviors					1001:1009	The retention behaviors	987:1009	The retention behaviors	987:1009	The retention behaviors were successfully deconvoluted for each contribution as a function of the modifier concentration by using the fitted parameters.
34923304	5	30	theme	retention	991:999	arg1	function					1069:1076	a function	1067:1076	a function of the modifier concentration	1067:1106	The retention behaviors were successfully deconvoluted for each contribution as a function of the modifier concentration by using the fitted parameters.
34923304	1	31	theme	solute	117:122	arg1	behavior					134:141	solute retention behavior	117:141	solute retention behavior	117:141	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	7	32	theme	molecules	1367:1375	arg1	number					1348:1353	the number	1344:1353	the number of modifier molecules present but independent of modifier identity	1344:1420	The standard Gibbs energy change SLo of benzene adsorption was found to depend linearly on the number of modifier molecules present but independent of modifier identity.
34923304	11	33	theme	energy	1801:1806	arg1	change					1808:1813	the standard Gibbs energy change	1782:1813	the standard Gibbs energy change SLo for the first-layer adsorption of modifiers	1782:1861	The results show that the standard Gibbs energy change SLo for the first-layer adsorption of modifiers changed linearly with the carbon number of modifier molecule.
34923304	11	34	theme	standard	1786:1793	arg1	change					1808:1813	the standard Gibbs energy change	1782:1813	the standard Gibbs energy change SLo for the first-layer adsorption of modifiers	1782:1861	The results show that the standard Gibbs energy change SLo for the first-layer adsorption of modifiers changed linearly with the carbon number of modifier molecule.
34923304	0	35	theme	reversed-phase	48:61	arg1	chromatography					70:83	reversed-phase liquid chromatography	48:83	reversed-phase liquid chromatography	48:83	Retention modeling and adsorption mechanisms in reversed-phase liquid chromatography.
34923304	1	36	theme	solutes	343:349	arg1	solutes					300:306	solutes	300:306	solutes	300:306	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	1	36	theme	solutes	343:349	arg1	adsorptions					328:338	the competitive adsorptions	312:338	the competitive adsorptions of solutes and solvent modifiers	312:371	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	5	37	theme	concentration	1094:1106	arg1	behaviors					1001:1009	The retention behaviors	987:1009	The retention behaviors	987:1009	The retention behaviors were successfully deconvoluted for each contribution as a function of the modifier concentration by using the fitted parameters.
34923304	5	37	theme	concentration	1094:1106	arg1	function					1069:1076	a function	1067:1076	a function of the modifier concentration	1067:1106	The retention behaviors were successfully deconvoluted for each contribution as a function of the modifier concentration by using the fitted parameters.
34923304	3	38	theme	linear	506:511	arg1	dependence					513:522	The linear dependence	502:522	The linear dependence of the Gibbs energy change of solute adsorption with respect to the modifier concentration	502:613	The linear dependence of the Gibbs energy change of solute adsorption with respect to the modifier concentration was assumed, and the model was fitted to the experimental results, with good agreement demonstrated between the experimental data and the model.
34923304	11	39	theme	SLo	1815:1817	arg1	change					1808:1813	the standard Gibbs energy change	1782:1813	the standard Gibbs energy change SLo for the first-layer adsorption of modifiers	1782:1861	The results show that the standard Gibbs energy change SLo for the first-layer adsorption of modifiers changed linearly with the carbon number of modifier molecule.
34923304	4	40	theme	dimensionless	822:834	arg1	groups					836:841	two key dimensionless groups	814:841	two key dimensionless groups that represented the reductions in the retention factors resulting from a weakened solvophobic interaction and modifier competitive adsorption	814:984	Retention behaviors were inferred to be determined by two key dimensionless groups that represented the reductions in the retention factors resulting from a weakened solvophobic interaction and modifier competitive adsorption.
34923304	3	41	theme	change	544:549	arg1	dependence					513:522	The linear dependence	502:522	The linear dependence of the Gibbs energy change of solute adsorption with respect to the modifier concentration	502:613	The linear dependence of the Gibbs energy change of solute adsorption with respect to the modifier concentration was assumed, and the model was fitted to the experimental results, with good agreement demonstrated between the experimental data and the model.
34923304	1	42	from	dependence	103:112	arg1	content					155:161	modifier content	146:161	modifier content	146:161	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	6	43	theme	contributions	1160:1172	arg1	effects					1144:1150	The effects	1140:1150	The effects of both contributions on the retention behaviors	1140:1199	The effects of both contributions on the retention behaviors were enhanced for the solutes with aromatic groups.
34923304	3	44	theme	experimental	727:738	arg1	data					740:743	the experimental data	723:743	the experimental data	723:743	The linear dependence of the Gibbs energy change of solute adsorption with respect to the modifier concentration was assumed, and the model was fitted to the experimental results, with good agreement demonstrated between the experimental data and the model.
34923304	3	45	theme	Gibbs	531:535	arg1	change					544:549	the Gibbs energy change	527:549	the Gibbs energy change of solute adsorption with respect to the modifier concentration	527:613	The linear dependence of the Gibbs energy change of solute adsorption with respect to the modifier concentration was assumed, and the model was fitted to the experimental results, with good agreement demonstrated between the experimental data and the model.
34923304	1	46	theme	solvophobic	270:280	arg1	forces					282:287	solvophobic forces	270:287	solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers	270:371	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	9	47	theme	mechanisms	1604:1613	arg1	contributions					1582:1594	the relative contributions	1569:1594	the relative contributions of both mechanisms to solute retention	1569:1633	Hence, the relative contributions of both mechanisms to solute retention depend greatly on the solute structure.
34923304	3	48	theme	solute	554:559	arg1	adsorption					561:570	solute adsorption	554:570	solute adsorption with respect to the modifier concentration	554:613	The linear dependence of the Gibbs energy change of solute adsorption with respect to the modifier concentration was assumed, and the model was fitted to the experimental results, with good agreement demonstrated between the experimental data and the model.
34923304	3	49	theme	modifier	592:599	arg1	concentration					601:613	the modifier concentration	588:613	the modifier concentration	588:613	The linear dependence of the Gibbs energy change of solute adsorption with respect to the modifier concentration was assumed, and the model was fitted to the experimental results, with good agreement demonstrated between the experimental data and the model.
34923304	10	50	theme	Perturbation	1675:1686	arg1	method					1688:1693	Perturbation method	1675:1693	Perturbation method	1675:1693	Perturbation method was performed to investigate the modifier adsorption mechanisms.
34923304	11	51	theme	modifier	1906:1913	arg1	molecule					1915:1922	modifier molecule	1906:1922	modifier molecule	1906:1922	The results show that the standard Gibbs energy change SLo for the first-layer adsorption of modifiers changed linearly with the carbon number of modifier molecule.
34923304	8	52	from	reduction	1494:1502	arg1	interactions					1523:1534	the solvophobic interactions	1507:1534	the solvophobic interactions	1507:1534	For the solutes associated with hydrogen-bonding groups, the degree of reduction in the solvophobic interactions was considerably reduced.
34923304	4	53	theme	modifier	954:961	arg1	adsorption					975:984	modifier competitive adsorption	954:984	modifier competitive adsorption	954:984	Retention behaviors were inferred to be determined by two key dimensionless groups that represented the reductions in the retention factors resulting from a weakened solvophobic interaction and modifier competitive adsorption.
34923304	8	54	theme	solvophobic	1511:1521	arg1	interactions					1523:1534	the solvophobic interactions	1507:1534	the solvophobic interactions	1507:1534	For the solutes associated with hydrogen-bonding groups, the degree of reduction in the solvophobic interactions was considerably reduced.
34923304	8	55	from	degree	1484:1489	arg1	interactions					1523:1534	the solvophobic interactions	1507:1534	the solvophobic interactions	1507:1534	For the solutes associated with hydrogen-bonding groups, the degree of reduction in the solvophobic interactions was considerably reduced.
34923304	1	56	theme	retention	124:132	arg1	behavior					134:141	solute retention behavior	117:141	solute retention behavior	117:141	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	6	57	with	solutes	1223:1229	arg1	groups					1245:1250	aromatic groups	1236:1250	aromatic groups	1236:1250	The effects of both contributions on the retention behaviors were enhanced for the solutes with aromatic groups.
34923304	4	58	theme	weakened	917:924	arg1	interaction					938:948	a weakened solvophobic interaction	915:948	a weakened solvophobic interaction	915:948	Retention behaviors were inferred to be determined by two key dimensionless groups that represented the reductions in the retention factors resulting from a weakened solvophobic interaction and modifier competitive adsorption.
34923304	9	59	theme	relative	1573:1580	arg1	contributions					1582:1594	the relative contributions	1569:1594	the relative contributions of both mechanisms to solute retention	1569:1633	Hence, the relative contributions of both mechanisms to solute retention depend greatly on the solute structure.
34923304	11	60	theme	modifiers	1853:1861	arg1	adsorption					1839:1848	the first-layer adsorption	1823:1848	the first-layer adsorption of modifiers	1823:1861	The results show that the standard Gibbs energy change SLo for the first-layer adsorption of modifiers changed linearly with the carbon number of modifier molecule.
34923304	5	61	theme	fitted	1121:1126	arg1	parameters					1128:1137	the fitted parameters	1117:1137	the fitted parameters	1117:1137	The retention behaviors were successfully deconvoluted for each contribution as a function of the modifier concentration by using the fitted parameters.
34923304	7	62	theme	identity	1413:1420	arg1	independent					1389:1399	independent	1389:1399	independent	1389:1399	The standard Gibbs energy change SLo of benzene adsorption was found to depend linearly on the number of modifier molecules present but independent of modifier identity.
34923304	1	63	theme	modifiers	363:371	arg1	solutes					300:306	solutes	300:306	solutes	300:306	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	1	63	theme	modifiers	363:371	arg1	adsorptions					328:338	the competitive adsorptions	312:338	the competitive adsorptions of solutes and solvent modifiers	312:371	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	12	64	theme	retention	2038:2046	arg1	description					2023:2033	a physically consistent quantitative description	1986:2033	a physically consistent quantitative description of retention	1986:2046	These results demonstrated that the proposed model can offer a physically consistent quantitative description of retention when solvent composition is varied.
34923304	1	65	theme	reversed-phase	166:179	arg1	chromatography					188:201	reversed-phase liquid chromatography	166:201	reversed-phase liquid chromatography	166:201	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	7	66	theme	Gibbs	1266:1270	arg1	change					1279:1284	The standard Gibbs energy change SLo	1253:1288	The standard Gibbs energy change SLo of benzene adsorption	1253:1310	The standard Gibbs energy change SLo of benzene adsorption was found to depend linearly on the number of modifier molecules present but independent of modifier identity.
34923304	12	67	theme	solvent	2053:2059	arg1	composition					2061:2071	solvent composition	2053:2071	solvent composition	2053:2071	These results demonstrated that the proposed model can offer a physically consistent quantitative description of retention when solvent composition is varied.
34923304	9	68	theme	solute	1618:1623	arg1	retention					1625:1633	solute retention	1618:1633	solute retention	1618:1633	Hence, the relative contributions of both mechanisms to solute retention depend greatly on the solute structure.
34923304	12	69	theme	consistent	1999:2008	arg1	description					2023:2033	a physically consistent quantitative description	1986:2033	a physically consistent quantitative description of retention	1986:2046	These results demonstrated that the proposed model can offer a physically consistent quantitative description of retention when solvent composition is varied.
34923304	7	70	theme	independent	1389:1399	arg1	molecules					1367:1375	modifier molecules	1358:1375	modifier molecules present but independent of modifier identity	1358:1420	The standard Gibbs energy change SLo of benzene adsorption was found to depend linearly on the number of modifier molecules present but independent of modifier identity.
34923304	2	71	theme	developed	410:418	arg1	model					420:424	the developed model	406:424	the developed model	406:424	The generality of the developed model was demonstrated by comparing the model with conventional retention models.
34923304	4	72	from	reductions	864:873	arg1	factors					892:898	the retention factors	878:898	the retention factors resulting from a weakened solvophobic interaction and modifier competitive adsorption	878:984	Retention behaviors were inferred to be determined by two key dimensionless groups that represented the reductions in the retention factors resulting from a weakened solvophobic interaction and modifier competitive adsorption.
34923304	7	73	theme	present	1377:1383	arg1	molecules					1367:1375	modifier molecules	1358:1375	modifier molecules present but independent of modifier identity	1358:1420	The standard Gibbs energy change SLo of benzene adsorption was found to depend linearly on the number of modifier molecules present but independent of modifier identity.
34923304	10	74	theme	modifier	1728:1735	arg1	mechanisms					1748:1757	the modifier adsorption mechanisms	1724:1757	the modifier adsorption mechanisms	1724:1757	Perturbation method was performed to investigate the modifier adsorption mechanisms.
34923304	9	75	theme	solute	1657:1662	arg1	structure					1664:1672	the solute structure	1653:1672	the solute structure	1653:1672	Hence, the relative contributions of both mechanisms to solute retention depend greatly on the solute structure.
34923304	7	76	theme	modifier	1358:1365	arg1	molecules					1367:1375	modifier molecules	1358:1375	modifier molecules present but independent of modifier identity	1358:1420	The standard Gibbs energy change SLo of benzene adsorption was found to depend linearly on the number of modifier molecules present but independent of modifier identity.
34923304	11	77	theme	Gibbs	1795:1799	arg1	change					1808:1813	the standard Gibbs energy change	1782:1813	the standard Gibbs energy change SLo for the first-layer adsorption of modifiers	1782:1861	The results show that the standard Gibbs energy change SLo for the first-layer adsorption of modifiers changed linearly with the carbon number of modifier molecule.
34923304	1	78	theme	competitive	316:326	arg1	adsorptions					328:338	the competitive adsorptions	312:338	the competitive adsorptions of solutes and solvent modifiers	312:371	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	8	79	theme	hydrogen-bonding	1455:1470	arg1	groups					1472:1477	hydrogen-bonding groups	1455:1477	hydrogen-bonding groups	1455:1477	For the solutes associated with hydrogen-bonding groups, the degree of reduction in the solvophobic interactions was considerably reduced.
34923304	0	80	theme	liquid	63:68	arg1	chromatography					70:83	reversed-phase liquid chromatography	48:83	reversed-phase liquid chromatography	48:83	Retention modeling and adsorption mechanisms in reversed-phase liquid chromatography.
34923304	5	81	theme	modifier	1085:1092	arg1	concentration					1094:1106	the modifier concentration	1081:1106	the modifier concentration	1081:1106	The retention behaviors were successfully deconvoluted for each contribution as a function of the modifier concentration by using the fitted parameters.
34923304	2	82	theme	retention	484:492	arg1	models					494:499	conventional retention models	471:499	conventional retention models	471:499	The generality of the developed model was demonstrated by comparing the model with conventional retention models.
34923304	3	83	theme	good	687:690	arg1	agreement					692:700	good agreement	687:700	good agreement demonstrated between the experimental data and the model	687:757	The linear dependence of the Gibbs energy change of solute adsorption with respect to the modifier concentration was assumed, and the model was fitted to the experimental results, with good agreement demonstrated between the experimental data and the model.
34923304	4	84	theme	key	818:820	arg1	groups					836:841	two key dimensionless groups	814:841	two key dimensionless groups that represented the reductions in the retention factors resulting from a weakened solvophobic interaction and modifier competitive adsorption	814:984	Retention behaviors were inferred to be determined by two key dimensionless groups that represented the reductions in the retention factors resulting from a weakened solvophobic interaction and modifier competitive adsorption.
34923304	12	85	theme	proposed	1961:1968	arg1	model					1970:1974	the proposed model	1957:1974	the proposed model	1957:1974	These results demonstrated that the proposed model can offer a physically consistent quantitative description of retention when solvent composition is varied.
34923304	6	86	theme	retention	1181:1189	arg1	behaviors					1191:1199	the retention behaviors	1177:1199	the retention behaviors	1177:1199	The effects of both contributions on the retention behaviors were enhanced for the solutes with aromatic groups.
34923304	1	87	theme	concentration	242:254	arg1	dependence					256:265	the concentration dependence	238:265	the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers	238:371	To interpret the dependence of solute retention behavior on modifier content in reversed-phase liquid chromatography, a theoretical framework, based on the concentration dependence of solvophobic forces imposed on solutes and the competitive adsorptions of solutes and solvent modifiers, was proposed.
34923304	7	88	theme	benzene	1293:1299	arg1	adsorption					1301:1310	benzene adsorption	1293:1310	benzene adsorption	1293:1310	The standard Gibbs energy change SLo of benzene adsorption was found to depend linearly on the number of modifier molecules present but independent of modifier identity.
34923304	8	89	theme	reduction	1494:1502	arg1	degree					1484:1489	the degree	1480:1489	the degree of reduction in the solvophobic interactions	1480:1534	For the solutes associated with hydrogen-bonding groups, the degree of reduction in the solvophobic interactions was considerably reduced.
34523465	0	0	theme	@	54:54	arg1	biochar					55:61	sulfide@biochar	47:61	sulfide@biochar	47:61	Improved Pb(II) removal in aqueous solution by sulfide@biochar and polysaccharose-FeS@ biochar composites: Efficiencies and mechanisms.
34523465	4	1	theme	@	656:656	arg1	WNS					657:659	FeS@WNS	653:659	FeS@WNS	653:659	The adsorption capacity of Pb(II) reached 63.5, 80.0, 84.7 mg g-1 under 0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS.
34523465	9	2	theme	WNS	1425:1427	arg1	sorbents					1381:1388	The novel sorbents	1371:1388	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS	1371:1427	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS can be used in Pb(II) wastewater treatment.
34523465	6	3	theme	spontaneous	1077:1087	arg1	process					1101:1107	a spontaneous endothermic process	1075:1107	a spontaneous endothermic process	1075:1107	△G < 0 (-3.7~-6.97) and △H > 0 (1.56-20.49) indicated that the reaction was a spontaneous endothermic process.
34523465	6	3	theme	spontaneous	1077:1087	arg1	reaction					1062:1069	the reaction	1058:1069	the reaction	1058:1069	△G < 0 (-3.7~-6.97) and △H > 0 (1.56-20.49) indicated that the reaction was a spontaneous endothermic process.
34523465	5	4	theme	chemical	978:985	arg1	adsorption					987:996	chemical adsorption	978:996	chemical adsorption	978:996	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	1	5	theme	@	203:203	arg1	WNS					204:206	FeS@WNS	200:206	FeS@WNS	200:206	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	5	theme	@	203:203	arg1	biochar					191:197	nano iron sulfide@ walnut shell biochar	159:197	nano iron sulfide@ walnut shell biochar (FeS@WNS)	159:207	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	0	6	theme	sulfide	47:53	arg1	biochar					55:61	sulfide@biochar	47:61	sulfide@biochar	47:61	Improved Pb(II) removal in aqueous solution by sulfide@biochar and polysaccharose-FeS@ biochar composites: Efficiencies and mechanisms.
34523465	4	7	theme	FeS	653:655	arg1	WNS					657:659	FeS@WNS	653:659	FeS@WNS	653:659	The adsorption capacity of Pb(II) reached 63.5, 80.0, 84.7 mg g-1 under 0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS.
34523465	1	8	theme	Novel	136:140	arg1	WNS					221:223	Starch-FeS@WNS	210:223	Starch-FeS@WNS	210:223	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	8	theme	Novel	136:140	arg1	biochars					142:149	Novel biochars	136:149	Novel biochars	136:149	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	8	theme	Novel	136:140	arg1	WNS					242:244	Chitosan-FeS@WNS	229:244	Chitosan-FeS@WNS	229:244	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	8	theme	Novel	136:140	arg1	biochar					191:197	nano iron sulfide@ walnut shell biochar	159:197	nano iron sulfide@ walnut shell biochar (FeS@WNS)	159:207	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	8	9	theme	@	1335:1335	arg1	WNS					1336:1338	Starch-FeS@WNS	1325:1338	Starch-FeS@WNS	1325:1338	Additionally, stability and reusability of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS was good.
34523465	4	10	theme	Chitosan-FeS	681:692	arg1	WNS					694:696	Chitosan-FeS@WNS	681:696	Chitosan-FeS@WNS	681:696	The adsorption capacity of Pb(II) reached 63.5, 80.0, 84.7 mg g-1 under 0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS.
34523465	7	11	theme	removal	1135:1141	arg1	mechanisms					1114:1123	The mechanisms	1110:1123	The mechanisms of Pb(II) removal from aqueous solutions	1110:1164	The mechanisms of Pb(II) removal from aqueous solutions involved electrostatic attraction, hydrogen bonding, physical adsorption, ion exchange and oxidoreduction.
34523465	8	12	theme	Chitosan-FeS	1344:1355	arg1	WNS					1357:1359	Chitosan-FeS@WNS	1344:1359	Chitosan-FeS@WNS	1344:1359	Additionally, stability and reusability of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS was good.
34523465	2	13	theme	FeS	430:432	arg1	defect					442:447	the defect	438:447	the defect of easy agglomeration	438:469	Nano FeS can be effectively improved lead ions (Pb(II)) removal and starch (or chitosan) improved the stability of FeS and the defect of easy agglomeration.
34523465	2	13	theme	FeS	430:432	arg1	stability					417:425	the stability	413:425	the stability of FeS	413:432	Nano FeS can be effectively improved lead ions (Pb(II)) removal and starch (or chitosan) improved the stability of FeS and the defect of easy agglomeration.
34523465	4	14	theme	adsorption	572:581	arg1	capacity					583:590	The adsorption capacity	568:590	The adsorption capacity of Pb(II)	568:600	The adsorption capacity of Pb(II) reached 63.5, 80.0, 84.7 mg g-1 under 0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS.
34523465	5	15	dep	model	798:802	arg1	mg·min					825:830	K2 = 0.001-0.005 g (mg·min)-1	805:833	K2 = 0.001-0.005 g (mg·min)-1	805:833	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	5	15	dep	model	798:802	arg1	R2 = 0.980-0.999					836:851	R2 = 0.980-0.999	836:851	R2 = 0.980-0.999	836:851	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	0	16	theme	@	85:85	arg1	composites					95:104	polysaccharose-FeS@ biochar composites	67:104	polysaccharose-FeS@ biochar composites	67:104	Improved Pb(II) removal in aqueous solution by sulfide@biochar and polysaccharose-FeS@ biochar composites: Efficiencies and mechanisms.
34523465	7	17	theme	electrostatic	1175:1187	arg1	attraction					1189:1198	electrostatic attraction	1175:1198	electrostatic attraction	1175:1198	The mechanisms of Pb(II) removal from aqueous solutions involved electrostatic attraction, hydrogen bonding, physical adsorption, ion exchange and oxidoreduction.
34523465	9	18	theme	Pb	1444:1445	arg1	treatment					1462:1470	Pb(II) wastewater treatment	1444:1470	Pb(II) wastewater treatment	1444:1470	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS can be used in Pb(II) wastewater treatment.
34523465	9	19	theme	wastewater	1451:1460	arg1	treatment					1462:1470	Pb(II) wastewater treatment	1444:1470	Pb(II) wastewater treatment	1444:1470	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS can be used in Pb(II) wastewater treatment.
34523465	4	20	theme	Pb	595:596	arg1	capacity					583:590	The adsorption capacity	568:590	The adsorption capacity of Pb(II)	568:600	The adsorption capacity of Pb(II) reached 63.5, 80.0, 84.7 mg g-1 under 0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS.
34523465	0	21	theme	polysaccharose-FeS	67:84	arg1	composites					95:104	polysaccharose-FeS@ biochar composites	67:104	polysaccharose-FeS@ biochar composites	67:104	Improved Pb(II) removal in aqueous solution by sulfide@biochar and polysaccharose-FeS@ biochar composites: Efficiencies and mechanisms.
34523465	1	22	theme	nano	280:283	arg1	FeS					285:287	nano FeS	280:287	nano FeS	280:287	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	2	23	theme	agglomeration	457:469	arg1	defect					442:447	the defect	438:447	the defect of easy agglomeration	438:469	Nano FeS can be effectively improved lead ions (Pb(II)) removal and starch (or chitosan) improved the stability of FeS and the defect of easy agglomeration.
34523465	2	23	theme	agglomeration	457:469	arg1	stability					417:425	the stability	413:425	the stability of FeS	413:432	Nano FeS can be effectively improved lead ions (Pb(II)) removal and starch (or chitosan) improved the stability of FeS and the defect of easy agglomeration.
34523465	8	24	theme	@	1319:1319	arg1	WNS					1320:1322	FeS@WNS	1316:1322	FeS@WNS	1316:1322	Additionally, stability and reusability of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS was good.
34523465	5	25	with	consistent	750:759	arg1	model					867:871	Langmuir model	858:871	Langmuir model (R2 = 0.974-1.00)	858:889	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	5	25	with	consistent	750:759	arg1	model					798:802	the pseudo-second-order kinetic model	766:802	the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999)	766:852	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	5	25	with	consistent	750:759	arg1	R2 = 0.974-1.00					874:888	R2 = 0.974-1.00	874:888	R2 = 0.974-1.00	874:888	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	0	26	theme	Pb	9:10	arg1	removal					16:22	Pb(II) removal	9:22	Pb(II) removal	9:22	Improved Pb(II) removal in aqueous solution by sulfide@biochar and polysaccharose-FeS@ biochar composites: Efficiencies and mechanisms.
34523465	6	27	theme	endothermic	1089:1099	arg1	process					1101:1107	a spontaneous endothermic process	1075:1107	a spontaneous endothermic process	1075:1107	△G < 0 (-3.7~-6.97) and △H > 0 (1.56-20.49) indicated that the reaction was a spontaneous endothermic process.
34523465	6	27	theme	endothermic	1089:1099	arg1	reaction					1062:1069	the reaction	1058:1069	the reaction	1058:1069	△G < 0 (-3.7~-6.97) and △H > 0 (1.56-20.49) indicated that the reaction was a spontaneous endothermic process.
34523465	2	28	theme	easy	452:455	arg1	agglomeration					457:469	easy agglomeration	452:469	easy agglomeration	452:469	Nano FeS can be effectively improved lead ions (Pb(II)) removal and starch (or chitosan) improved the stability of FeS and the defect of easy agglomeration.
34523465	7	29	theme	Pb	1128:1129	arg1	removal					1135:1141	Pb(II) removal	1128:1141	Pb(II) removal from aqueous solutions	1128:1164	The mechanisms of Pb(II) removal from aqueous solutions involved electrostatic attraction, hydrogen bonding, physical adsorption, ion exchange and oxidoreduction.
34523465	9	30	theme	Chitosan-FeS	1412:1423	arg1	WNS					1425:1427	Chitosan-FeS@WNS	1412:1427	Chitosan-FeS@WNS	1412:1427	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS can be used in Pb(II) wastewater treatment.
34523465	7	31	from	solutions	1156:1164	arg1	mechanisms					1114:1123	The mechanisms	1110:1123	The mechanisms of Pb(II) removal from aqueous solutions	1110:1164	The mechanisms of Pb(II) removal from aqueous solutions involved electrostatic attraction, hydrogen bonding, physical adsorption, ion exchange and oxidoreduction.
34523465	7	31	from	solutions	1156:1164	arg1	removal					1135:1141	Pb(II) removal	1128:1141	Pb(II) removal from aqueous solutions	1128:1164	The mechanisms of Pb(II) removal from aqueous solutions involved electrostatic attraction, hydrogen bonding, physical adsorption, ion exchange and oxidoreduction.
34523465	1	32	theme	Starch-FeS	210:219	arg1	WNS					221:223	Starch-FeS@WNS	210:223	Starch-FeS@WNS	210:223	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	32	theme	Starch-FeS	210:219	arg1	biochars					142:149	Novel biochars	136:149	Novel biochars	136:149	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	7	33	theme	physical	1219:1226	arg1	adsorption					1228:1237	physical adsorption	1219:1237	physical adsorption	1219:1237	The mechanisms of Pb(II) removal from aqueous solutions involved electrostatic attraction, hydrogen bonding, physical adsorption, ion exchange and oxidoreduction.
34523465	1	34	theme	nano	159:162	arg1	WNS					204:206	FeS@WNS	200:206	FeS@WNS	200:206	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	34	theme	nano	159:162	arg1	biochars					142:149	Novel biochars	136:149	Novel biochars	136:149	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	34	theme	nano	159:162	arg1	biochar					191:197	nano iron sulfide@ walnut shell biochar	159:197	nano iron sulfide@ walnut shell biochar (FeS@WNS)	159:207	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	9	35	theme	novel	1375:1379	arg1	sorbents					1381:1388	The novel sorbents	1371:1388	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS	1371:1427	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS can be used in Pb(II) wastewater treatment.
34523465	1	36	theme	@	220:220	arg1	WNS					221:223	Starch-FeS@WNS	210:223	Starch-FeS@WNS	210:223	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	36	theme	@	220:220	arg1	biochars					142:149	Novel biochars	136:149	Novel biochars	136:149	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	4	37	theme	@	693:693	arg1	WNS					694:696	Chitosan-FeS@WNS	681:696	Chitosan-FeS@WNS	681:696	The adsorption capacity of Pb(II) reached 63.5, 80.0, 84.7 mg g-1 under 0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS.
34523465	1	38	theme	iron	164:167	arg1	WNS					204:206	FeS@WNS	200:206	FeS@WNS	200:206	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	38	theme	iron	164:167	arg1	biochars					142:149	Novel biochars	136:149	Novel biochars	136:149	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	38	theme	iron	164:167	arg1	biochar					191:197	nano iron sulfide@ walnut shell biochar	159:197	nano iron sulfide@ walnut shell biochar (FeS@WNS)	159:207	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	2	39	dep	ions	357:360	arg1	improved					404:411	improved	404:411	improved the stability of FeS and the defect of easy agglomeration	404:469	Nano FeS can be effectively improved lead ions (Pb(II)) removal and starch (or chitosan) improved the stability of FeS and the defect of easy agglomeration.
34523465	0	40	theme	biochar	87:93	arg1	composites					95:104	polysaccharose-FeS@ biochar composites	67:104	polysaccharose-FeS@ biochar composites	67:104	Improved Pb(II) removal in aqueous solution by sulfide@biochar and polysaccharose-FeS@ biochar composites: Efficiencies and mechanisms.
34523465	5	41	theme	Pb	717:718	arg1	adsorption					703:712	The adsorption	699:712	The adsorption of Pb(II) on the materials	699:739	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	5	41	theme	Pb	717:718	arg1	consistent					750:759	consistent	750:759	consistent	750:759	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	1	42	theme	sulfide	169:175	arg1	WNS					204:206	FeS@WNS	200:206	FeS@WNS	200:206	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	42	theme	sulfide	169:175	arg1	biochars					142:149	Novel biochars	136:149	Novel biochars	136:149	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	42	theme	sulfide	169:175	arg1	biochar					191:197	nano iron sulfide@ walnut shell biochar	159:197	nano iron sulfide@ walnut shell biochar (FeS@WNS)	159:207	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	5	43	theme	Pb	926:927	arg1	adsorption					912:921	the adsorption	908:921	the adsorption of Pb(II)	908:931	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	5	43	theme	Pb	926:927	arg1	adsorption					954:963	monolayer adsorption	944:963	monolayer adsorption dominated by chemical adsorption	944:996	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	9	44	theme	@	1403:1403	arg1	WNS					1404:1406	Starch-FeS@WNS	1393:1406	Starch-FeS@WNS	1393:1406	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS can be used in Pb(II) wastewater treatment.
34523465	8	45	theme	WNS	1336:1338	arg1	reusability					1301:1311	reusability	1301:1311	reusability	1301:1311	Additionally, stability and reusability of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS was good.
34523465	8	45	theme	WNS	1336:1338	arg1	stability					1287:1295	stability	1287:1295	stability	1287:1295	Additionally, stability and reusability of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS was good.
34523465	1	46	theme	@	176:176	arg1	WNS					204:206	FeS@WNS	200:206	FeS@WNS	200:206	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	46	theme	@	176:176	arg1	biochars					142:149	Novel biochars	136:149	Novel biochars	136:149	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	46	theme	@	176:176	arg1	biochar					191:197	nano iron sulfide@ walnut shell biochar	159:197	nano iron sulfide@ walnut shell biochar (FeS@WNS)	159:207	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	8	47	theme	WNS	1357:1359	arg1	reusability					1301:1311	reusability	1301:1311	reusability	1301:1311	Additionally, stability and reusability of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS was good.
34523465	8	47	theme	WNS	1357:1359	arg1	stability					1287:1295	stability	1287:1295	stability	1287:1295	Additionally, stability and reusability of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS was good.
34523465	1	48	theme	Chitosan-FeS	229:240	arg1	biochars					142:149	Novel biochars	136:149	Novel biochars	136:149	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	48	theme	Chitosan-FeS	229:240	arg1	WNS					242:244	Chitosan-FeS@WNS	229:244	Chitosan-FeS@WNS	229:244	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	4	49	theme	WNS	694:696	arg1	0.5 g L-1					640:648	0.5 g L-1	640:648	0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS	640:696	The adsorption capacity of Pb(II) reached 63.5, 80.0, 84.7 mg g-1 under 0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS.
34523465	7	50	theme	ion	1240:1242	arg1	exchange					1244:1251	ion exchange	1240:1251	ion exchange	1240:1251	The mechanisms of Pb(II) removal from aqueous solutions involved electrostatic attraction, hydrogen bonding, physical adsorption, ion exchange and oxidoreduction.
34523465	1	51	theme	walnut	178:183	arg1	WNS					204:206	FeS@WNS	200:206	FeS@WNS	200:206	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	51	theme	walnut	178:183	arg1	biochars					142:149	Novel biochars	136:149	Novel biochars	136:149	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	51	theme	walnut	178:183	arg1	biochar					191:197	nano iron sulfide@ walnut shell biochar	159:197	nano iron sulfide@ walnut shell biochar (FeS@WNS)	159:207	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	0	52	theme	aqueous	27:33	arg1	solution					35:42	aqueous solution	27:42	aqueous solution	27:42	Improved Pb(II) removal in aqueous solution by sulfide@biochar and polysaccharose-FeS@ biochar composites: Efficiencies and mechanisms.
34523465	1	53	theme	@	241:241	arg1	biochars					142:149	Novel biochars	136:149	Novel biochars	136:149	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	53	theme	@	241:241	arg1	WNS					242:244	Chitosan-FeS@WNS	229:244	Chitosan-FeS@WNS	229:244	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	4	54	theme	@	672:672	arg1	WNS					673:675	Starch-FeS@WNS	662:675	Starch-FeS@WNS	662:675	The adsorption capacity of Pb(II) reached 63.5, 80.0, 84.7 mg g-1 under 0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS.
34523465	7	55	theme	aqueous	1148:1154	arg1	solutions					1156:1164	aqueous solutions	1148:1164	aqueous solutions	1148:1164	The mechanisms of Pb(II) removal from aqueous solutions involved electrostatic attraction, hydrogen bonding, physical adsorption, ion exchange and oxidoreduction.
34523465	7	56	theme	hydrogen	1201:1208	arg1	bonding					1210:1216	hydrogen bonding	1201:1216	hydrogen bonding	1201:1216	The mechanisms of Pb(II) removal from aqueous solutions involved electrostatic attraction, hydrogen bonding, physical adsorption, ion exchange and oxidoreduction.
34523465	9	57	theme	WNS	1404:1406	arg1	sorbents					1381:1388	The novel sorbents	1371:1388	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS	1371:1427	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS can be used in Pb(II) wastewater treatment.
34523465	8	58	theme	FeS	1316:1318	arg1	WNS					1320:1322	FeS@WNS	1316:1322	FeS@WNS	1316:1322	Additionally, stability and reusability of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS was good.
34523465	4	59	theme	Starch-FeS	662:671	arg1	WNS					673:675	Starch-FeS@WNS	662:675	Starch-FeS@WNS	662:675	The adsorption capacity of Pb(II) reached 63.5, 80.0, 84.7 mg g-1 under 0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS.
34523465	5	60	theme	kinetic	790:796	arg1	model					798:802	the pseudo-second-order kinetic model	766:802	the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999)	766:852	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	5	61	theme	pseudo-second-order	770:788	arg1	model					798:802	the pseudo-second-order kinetic model	766:802	the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999)	766:852	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	9	62	used	used	1436:1439	arg2	sorbents					1381:1388	The novel sorbents	1371:1388	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS	1371:1427	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS can be used in Pb(II) wastewater treatment.
34523465	7	63	from	mechanisms	1114:1123	arg1	solutions					1156:1164	aqueous solutions	1148:1164	aqueous solutions	1148:1164	The mechanisms of Pb(II) removal from aqueous solutions involved electrostatic attraction, hydrogen bonding, physical adsorption, ion exchange and oxidoreduction.
34523465	9	64	theme	@	1424:1424	arg1	WNS					1425:1427	Chitosan-FeS@WNS	1412:1427	Chitosan-FeS@WNS	1412:1427	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS can be used in Pb(II) wastewater treatment.
34523465	8	65	theme	@	1356:1356	arg1	WNS					1357:1359	Chitosan-FeS@WNS	1344:1359	Chitosan-FeS@WNS	1344:1359	Additionally, stability and reusability of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS was good.
34523465	1	66	theme	shell	185:189	arg1	WNS					204:206	FeS@WNS	200:206	FeS@WNS	200:206	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	66	theme	shell	185:189	arg1	biochars					142:149	Novel biochars	136:149	Novel biochars	136:149	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	66	theme	shell	185:189	arg1	biochar					191:197	nano iron sulfide@ walnut shell biochar	159:197	nano iron sulfide@ walnut shell biochar (FeS@WNS)	159:207	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	4	67	theme	WNS	673:675	arg1	0.5 g L-1					640:648	0.5 g L-1	640:648	0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS	640:696	The adsorption capacity of Pb(II) reached 63.5, 80.0, 84.7 mg g-1 under 0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS.
34523465	4	68	theme	WNS	657:659	arg1	0.5 g L-1					640:648	0.5 g L-1	640:648	0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS	640:696	The adsorption capacity of Pb(II) reached 63.5, 80.0, 84.7 mg g-1 under 0.5 g L-1 of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS.
34523465	5	69	theme	monolayer	944:952	arg1	adsorption					912:921	the adsorption	908:921	the adsorption of Pb(II)	908:931	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	5	69	theme	monolayer	944:952	arg1	adsorption					954:963	monolayer adsorption	944:963	monolayer adsorption dominated by chemical adsorption	944:996	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	5	70	theme	K2 = 0.001-0.005 g	805:822	arg1	mg·min					825:830	K2 = 0.001-0.005 g (mg·min)-1	805:833	K2 = 0.001-0.005 g (mg·min)-1	805:833	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	5	70	theme	K2 = 0.001-0.005 g	805:822	arg1	R2 = 0.980-0.999					836:851	R2 = 0.980-0.999	836:851	R2 = 0.980-0.999	836:851	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	2	71	theme	Nano	315:318	arg1	FeS					320:322	Nano FeS	315:322	Nano FeS	315:322	Nano FeS can be effectively improved lead ions (Pb(II)) removal and starch (or chitosan) improved the stability of FeS and the defect of easy agglomeration.
34523465	5	72	from	adsorption	703:712	arg1	materials					731:739	the materials	727:739	the materials	727:739	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	8	73	theme	Starch-FeS	1325:1334	arg1	WNS					1336:1338	Starch-FeS@WNS	1325:1338	Starch-FeS@WNS	1325:1338	Additionally, stability and reusability of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS was good.
34523465	2	74	theme	lead	352:355	arg1	Pb					363:364	Pb(II)	363:368	Pb(II)	363:368	Nano FeS can be effectively improved lead ions (Pb(II)) removal and starch (or chitosan) improved the stability of FeS and the defect of easy agglomeration.
34523465	2	74	theme	lead	352:355	arg1	ions					357:360	lead ions	352:360	lead ions (Pb(II)) removal and starch (or chitosan) improved the stability of FeS and the defect of easy agglomeration	352:469	Nano FeS can be effectively improved lead ions (Pb(II)) removal and starch (or chitosan) improved the stability of FeS and the defect of easy agglomeration.
34523465	5	75	theme	Langmuir	858:865	arg1	model					867:871	Langmuir model	858:871	Langmuir model (R2 = 0.974-1.00)	858:889	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	5	75	theme	Langmuir	858:865	arg1	R2 = 0.974-1.00					874:888	R2 = 0.974-1.00	874:888	R2 = 0.974-1.00	874:888	The adsorption of Pb(II) on the materials was more consistent with the pseudo-second-order kinetic model (K2 = 0.001-0.005 g (mg·min)-1, R2 = 0.980-0.999) and Langmuir model (R2 = 0.974-1.00), indicating that the adsorption of Pb(II) was mainly monolayer adsorption dominated by chemical adsorption.
34523465	0	76	dep	Improved	0:7	arg1	mechanisms					124:133	mechanisms	124:133	mechanisms	124:133	Improved Pb(II) removal in aqueous solution by sulfide@biochar and polysaccharose-FeS@ biochar composites: Efficiencies and mechanisms.
34523465	0	76	dep	Improved	0:7	arg1	Efficiencies					107:118	Efficiencies	107:118	Efficiencies	107:118	Improved Pb(II) removal in aqueous solution by sulfide@biochar and polysaccharose-FeS@ biochar composites: Efficiencies and mechanisms.
34523465	8	77	theme	WNS	1320:1322	arg1	reusability					1301:1311	reusability	1301:1311	reusability	1301:1311	Additionally, stability and reusability of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS was good.
34523465	8	77	theme	WNS	1320:1322	arg1	stability					1287:1295	stability	1287:1295	stability	1287:1295	Additionally, stability and reusability of FeS@WNS, Starch-FeS@WNS and Chitosan-FeS@WNS was good.
34523465	9	78	theme	Starch-FeS	1393:1402	arg1	WNS					1404:1406	Starch-FeS@WNS	1393:1406	Starch-FeS@WNS	1393:1406	The novel sorbents of Starch-FeS@WNS and Chitosan-FeS@WNS can be used in Pb(II) wastewater treatment.
34523465	1	79	theme	FeS	200:202	arg1	WNS					204:206	FeS@WNS	200:206	FeS@WNS	200:206	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
34523465	1	79	theme	FeS	200:202	arg1	biochar					191:197	nano iron sulfide@ walnut shell biochar	159:197	nano iron sulfide@ walnut shell biochar (FeS@WNS)	159:207	Novel biochars, namely nano iron sulfide@ walnut shell biochar (FeS@WNS), Starch-FeS@WNS and Chitosan-FeS@WNS, were prepared by WNS loaded with nano FeS and starch (or chitosan).
33712145	5	0	theme	first	832:836	arg1	time					838:841	the first time	828:841	the first time	828:841	In this study we compare, for the first time, differences and similarities in the structure of heparan sulfate in human and bat lungs.
33712145	6	1	gly	glycoprotein	969:980	arg1	glycoprotein					969:980	the spike glycoprotein	959:980	the spike glycoprotein of COVID-19	959:992	Furthermore, we show that the spike glycoprotein of COVID-19 binds 3.5 times stronger to human lung heparan sulfate than bat lung heparan sulfate.
33712145	6	2	theme	bat	1054:1056	arg1	sulfate					1071:1077	bat lung heparan sulfate	1054:1077	bat lung heparan sulfate	1054:1077	Furthermore, we show that the spike glycoprotein of COVID-19 binds 3.5 times stronger to human lung heparan sulfate than bat lung heparan sulfate.
33712145	1	3	theme	unprecedented	227:239	arg1	rate					241:244	an unprecedented rate	224:244	an unprecedented rate around the world	224:261	Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a pandemic and continues to spread at an unprecedented rate around the world.
33712145	5	4	theme	bat	922:924	arg1	lungs					926:930	human and bat lungs	912:930	human and bat lungs	912:930	In this study we compare, for the first time, differences and similarities in the structure of heparan sulfate in human and bat lungs.
33712145	3	5	theme	respiratory	502:512	arg1	MERS-CoV					524:531	MERS-CoV	524:531	MERS-CoV	524:531	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	5	theme	respiratory	502:512	arg1	syndrome					514:521	Middle East respiratory syndrome	490:521	Middle East respiratory syndrome (MERS-CoV)	490:532	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	6	dep	syndrome	463:470	arg1	the					426:428	the	426:428	the	426:428	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	0	7	theme	spike	66:70	arg1	protein					72:78	the spike protein	62:78	the spike protein of SARS-CoV-2 virus	62:98	Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus.
33712145	5	8	theme	sulfate	901:907	arg1	structure					880:888	the structure	876:888	the structure of heparan sulfate in human and bat lungs	876:930	In this study we compare, for the first time, differences and similarities in the structure of heparan sulfate in human and bat lungs.
33712145	5	9	from	lungs	926:930	arg1	structure					880:888	the structure	876:888	the structure of heparan sulfate in human and bat lungs	876:930	In this study we compare, for the first time, differences and similarities in the structure of heparan sulfate in human and bat lungs.
33712145	3	10	theme	respiratory	451:461	arg1	syndrome					463:470	severe acute respiratory syndrome	438:470	severe acute respiratory syndrome (SARS-CoV-1)	438:483	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	10	theme	respiratory	451:461	arg1	SARS-CoV-1					473:482	SARS-CoV-1	473:482	SARS-CoV-1	473:482	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	0	11	theme	SARS-CoV-2	83:92	arg1	virus					94:98	SARS-CoV-2 virus	83:98	SARS-CoV-2 virus	83:98	Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus.
33712145	0	12	from	lung	36:39	arg1	sulfates					8:15	Heparan sulfates	0:15	Heparan sulfates from bat and human lung	0:39	Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus.
33712145	0	12	from	lung	36:39	arg1	binding					51:57	their binding	45:57	their binding to the spike protein of SARS-CoV-2 virus	45:98	Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus.
33712145	3	13	theme	severe	438:443	arg1	syndrome					463:470	severe acute respiratory syndrome	438:470	severe acute respiratory syndrome (SARS-CoV-1)	438:483	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	13	theme	severe	438:443	arg1	SARS-CoV-1					473:482	SARS-CoV-1	473:482	SARS-CoV-1	473:482	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	14	theme	Middle	490:495	arg1	MERS-CoV					524:531	MERS-CoV	524:531	MERS-CoV	524:531	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	14	theme	Middle	490:495	arg1	syndrome					514:521	Middle East respiratory syndrome	490:521	Middle East respiratory syndrome (MERS-CoV)	490:532	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	6	15	theme	spike	963:967	arg1	glycoprotein					969:980	the spike glycoprotein	959:980	the spike glycoprotein of COVID-19	959:992	Furthermore, we show that the spike glycoprotein of COVID-19 binds 3.5 times stronger to human lung heparan sulfate than bat lung heparan sulfate.
33712145	3	16	dep	unknown	624:630	arg1	secondary					632:640	secondary	632:640	secondary	632:640	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	6	17	theme	heparan	1033:1039	arg1	sulfate					1041:1047	human lung heparan sulfate	1022:1047	human lung heparan sulfate than bat lung heparan sulfate	1022:1077	Furthermore, we show that the spike glycoprotein of COVID-19 binds 3.5 times stronger to human lung heparan sulfate than bat lung heparan sulfate.
33712145	3	18	theme	East	497:500	arg1	MERS-CoV					524:531	MERS-CoV	524:531	MERS-CoV	524:531	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	18	theme	East	497:500	arg1	syndrome					514:521	Middle East respiratory syndrome	490:521	Middle East respiratory syndrome (MERS-CoV)	490:532	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	2	19	theme	fight	361:365	arg1	disease					382:388	fight its associated disease	361:388	fight its associated disease in humans	361:398	Although a vaccine has recently been approved, there are currently few effective therapeutics to fight its associated disease in humans, COVID-19.
33712145	2	19	theme	fight	361:365	arg1	COVID-19					401:408	COVID-19	401:408	COVID-19	401:408	Although a vaccine has recently been approved, there are currently few effective therapeutics to fight its associated disease in humans, COVID-19.
33712145	5	20	from	similarities	860:871	arg1	structure					880:888	the structure	876:888	the structure of heparan sulfate in human and bat lungs	876:930	In this study we compare, for the first time, differences and similarities in the structure of heparan sulfate in human and bat lungs.
33712145	4	21	theme	different	680:688	arg1	receptors					717:725	different protein-based cell-surface receptors	680:725	different protein-based cell-surface receptors	680:725	While each of these viruses has different protein-based cell-surface receptors, each rely on the glycosaminoglycan, heparan sulfate as a co-receptor.
33712145	6	22	theme	COVID-19	985:992	arg1	glycoprotein					969:980	the spike glycoprotein	959:980	the spike glycoprotein of COVID-19	959:992	Furthermore, we show that the spike glycoprotein of COVID-19 binds 3.5 times stronger to human lung heparan sulfate than bat lung heparan sulfate.
33712145	0	23	theme	Heparan	0:6	arg1	sulfates					8:15	Heparan sulfates	0:15	Heparan sulfates from bat and human lung	0:39	Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus.
33712145	6	24	theme	heparan	1063:1069	arg1	sulfate					1071:1077	bat lung heparan sulfate	1054:1077	bat lung heparan sulfate	1054:1077	Furthermore, we show that the spike glycoprotein of COVID-19 binds 3.5 times stronger to human lung heparan sulfate than bat lung heparan sulfate.
33712145	3	25	theme	zoonotic	546:553	arg1	viruses					567:573	zoonotic respiratory viruses	546:573	zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host	546:645	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	4	26	theme	cell-surface	704:715	arg1	receptors					717:725	different protein-based cell-surface receptors	680:725	different protein-based cell-surface receptors	680:725	While each of these viruses has different protein-based cell-surface receptors, each rely on the glycosaminoglycan, heparan sulfate as a co-receptor.
33712145	3	27	theme	related	430:436	arg1	syndrome					463:470	severe acute respiratory syndrome	438:470	severe acute respiratory syndrome (SARS-CoV-1)	438:483	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	27	theme	related	430:436	arg1	SARS-CoV-1					473:482	SARS-CoV-1	473:482	SARS-CoV-1	473:482	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	6	28	theme	lung	1028:1031	arg1	sulfate					1041:1047	human lung heparan sulfate	1022:1047	human lung heparan sulfate than bat lung heparan sulfate	1022:1077	Furthermore, we show that the spike glycoprotein of COVID-19 binds 3.5 times stronger to human lung heparan sulfate than bat lung heparan sulfate.
33712145	4	29	contain	has	676:678	arg2	receptors					717:725	different protein-based cell-surface receptors	680:725	different protein-based cell-surface receptors	680:725	While each of these viruses has different protein-based cell-surface receptors, each rely on the glycosaminoglycan, heparan sulfate as a co-receptor.
33712145	4	29	contain	has	676:678	arg1	each					654:657	each	654:657	each	654:657	While each of these viruses has different protein-based cell-surface receptors, each rely on the glycosaminoglycan, heparan sulfate as a co-receptor.
33712145	4	29	contain	has	676:678	arg1	viruses					668:674	these viruses	662:674	these viruses	662:674	While each of these viruses has different protein-based cell-surface receptors, each rely on the glycosaminoglycan, heparan sulfate as a co-receptor.
33712145	0	30	theme	virus	94:98	arg1	protein					72:78	the spike protein	62:78	the spike protein of SARS-CoV-2 virus	62:98	Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus.
33712145	4	31	theme	protein-based	690:702	arg1	receptors					717:725	different protein-based cell-surface receptors	680:725	different protein-based cell-surface receptors	680:725	While each of these viruses has different protein-based cell-surface receptors, each rely on the glycosaminoglycan, heparan sulfate as a co-receptor.
33712145	1	32	theme	respiratory	114:124	arg1	SARS-CoV-2					158:167	SARS-CoV-2	158:167	SARS-CoV-2	158:167	Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a pandemic and continues to spread at an unprecedented rate around the world.
33712145	1	32	theme	respiratory	114:124	arg1	coronavirus-2					143:155	Severe acute respiratory syndrome-related coronavirus-2	101:155	Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2)	101:168	Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a pandemic and continues to spread at an unprecedented rate around the world.
33712145	0	33	theme	human	30:34	arg1	lung					36:39	human lung	30:39	human lung	30:39	Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus.
33712145	3	34	theme	respiratory	555:565	arg1	viruses					567:573	zoonotic respiratory viruses	546:573	zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host	546:645	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	4	35	dep	sulfate	772:778	arg1	heparan					764:770	the glycosaminoglycan, heparan sulfate	741:778	heparan	764:770	While each of these viruses has different protein-based cell-surface receptors, each rely on the glycosaminoglycan, heparan sulfate as a co-receptor.
33712145	2	36	theme	associated	371:380	arg1	disease					382:388	fight its associated disease	361:388	fight its associated disease in humans	361:398	Although a vaccine has recently been approved, there are currently few effective therapeutics to fight its associated disease in humans, COVID-19.
33712145	2	36	theme	associated	371:380	arg1	COVID-19					401:408	COVID-19	401:408	COVID-19	401:408	Although a vaccine has recently been approved, there are currently few effective therapeutics to fight its associated disease in humans, COVID-19.
33712145	3	37	theme	primary	597:603	arg1	host					605:608	the primary host	593:608	the primary host	593:608	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	37	theme	primary	597:603	arg1	bats					585:588	bats	585:588	bats	585:588	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	6	38	theme	human	1022:1026	arg1	sulfate					1041:1047	human lung heparan sulfate	1022:1047	human lung heparan sulfate than bat lung heparan sulfate	1022:1077	Furthermore, we show that the spike glycoprotein of COVID-19 binds 3.5 times stronger to human lung heparan sulfate than bat lung heparan sulfate.
33712145	1	39	theme	syndrome-related	126:141	arg1	SARS-CoV-2					158:167	SARS-CoV-2	158:167	SARS-CoV-2	158:167	Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a pandemic and continues to spread at an unprecedented rate around the world.
33712145	1	39	theme	syndrome-related	126:141	arg1	coronavirus-2					143:155	Severe acute respiratory syndrome-related coronavirus-2	101:155	Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2)	101:168	Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a pandemic and continues to spread at an unprecedented rate around the world.
33712145	5	40	from	structure	880:888	arg1	lungs					926:930	human and bat lungs	912:930	human and bat lungs	912:930	In this study we compare, for the first time, differences and similarities in the structure of heparan sulfate in human and bat lungs.
33712145	5	41	from	differences	844:854	arg1	structure					880:888	the structure	876:888	the structure of heparan sulfate in human and bat lungs	876:930	In this study we compare, for the first time, differences and similarities in the structure of heparan sulfate in human and bat lungs.
33712145	3	42	theme	unknown	624:630	arg1	bats					585:588	bats	585:588	bats	585:588	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	42	theme	unknown	624:630	arg1	host					642:645	an as yet unknown secondary host	614:645	an as yet unknown secondary host	614:645	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	1	43	theme	Severe	101:106	arg1	SARS-CoV-2					158:167	SARS-CoV-2	158:167	SARS-CoV-2	158:167	Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a pandemic and continues to spread at an unprecedented rate around the world.
33712145	1	43	theme	Severe	101:106	arg1	coronavirus-2					143:155	Severe acute respiratory syndrome-related coronavirus-2	101:155	Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2)	101:168	Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a pandemic and continues to spread at an unprecedented rate around the world.
33712145	6	44	theme	lung	1058:1061	arg1	sulfate					1071:1077	bat lung heparan sulfate	1054:1077	bat lung heparan sulfate	1054:1077	Furthermore, we show that the spike glycoprotein of COVID-19 binds 3.5 times stronger to human lung heparan sulfate than bat lung heparan sulfate.
33712145	3	45	contain	have	580:583	arg1	viruses					567:573	zoonotic respiratory viruses	546:573	zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host	546:645	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	45	contain	have	580:583	arg2	host					642:645	an as yet unknown secondary host	614:645	an as yet unknown secondary host	614:645	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	45	contain	have	580:583	arg2	host					605:608	the primary host	593:608	the primary host	593:608	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	45	contain	have	580:583	arg2	bats					585:588	bats	585:588	bats	585:588	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	5	46	theme	human	912:916	arg1	lungs					926:930	human and bat lungs	912:930	human and bat lungs	912:930	In this study we compare, for the first time, differences and similarities in the structure of heparan sulfate in human and bat lungs.
33712145	5	47	theme	heparan	893:899	arg1	sulfate					901:907	heparan sulfate	893:907	heparan sulfate in human and bat lungs	893:930	In this study we compare, for the first time, differences and similarities in the structure of heparan sulfate in human and bat lungs.
33712145	2	48	from	disease	382:388	arg1	humans					393:398	humans	393:398	humans	393:398	Although a vaccine has recently been approved, there are currently few effective therapeutics to fight its associated disease in humans, COVID-19.
33712145	1	49	theme	acute	108:112	arg1	SARS-CoV-2					158:167	SARS-CoV-2	158:167	SARS-CoV-2	158:167	Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a pandemic and continues to spread at an unprecedented rate around the world.
33712145	1	49	theme	acute	108:112	arg1	coronavirus-2					143:155	Severe acute respiratory syndrome-related coronavirus-2	101:155	Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2)	101:168	Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a pandemic and continues to spread at an unprecedented rate around the world.
33712145	3	50	theme	acute	445:449	arg1	syndrome					463:470	severe acute respiratory syndrome	438:470	severe acute respiratory syndrome (SARS-CoV-1)	438:483	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	3	50	theme	acute	445:449	arg1	SARS-CoV-1					473:482	SARS-CoV-1	473:482	SARS-CoV-1	473:482	SARS-CoV-2 and the related severe acute respiratory syndrome (SARS-CoV-1), and Middle East respiratory syndrome (MERS-CoV) result from zoonotic respiratory viruses that have bats as the primary host and an as yet unknown secondary host.
33712145	5	51	from	sulfate	901:907	arg1	lungs					926:930	human and bat lungs	912:930	human and bat lungs	912:930	In this study we compare, for the first time, differences and similarities in the structure of heparan sulfate in human and bat lungs.
33712145	2	52	theme	effective	335:343	arg1	therapeutics					345:356	few effective therapeutics	331:356	few effective therapeutics to fight its associated disease in humans, COVID-19	331:408	Although a vaccine has recently been approved, there are currently few effective therapeutics to fight its associated disease in humans, COVID-19.
33712145	0	53	from	bat	22:24	arg1	sulfates					8:15	Heparan sulfates	0:15	Heparan sulfates from bat and human lung	0:39	Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus.
33712145	0	53	from	bat	22:24	arg1	binding					51:57	their binding	45:57	their binding to the spike protein of SARS-CoV-2 virus	45:98	Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus.
33712145	4	54	theme	glycosaminoglycan	745:761	arg1	sulfate					772:778	the glycosaminoglycan, heparan sulfate	741:778	sulfate	772:778	While each of these viruses has different protein-based cell-surface receptors, each rely on the glycosaminoglycan, heparan sulfate as a co-receptor.
33712145	2	55	theme	few	331:333	arg1	therapeutics					345:356	few effective therapeutics	331:356	few effective therapeutics to fight its associated disease in humans, COVID-19	331:408	Although a vaccine has recently been approved, there are currently few effective therapeutics to fight its associated disease in humans, COVID-19.
32590087	5	0	theme	important	816:824	arg1	effect					826:831	an important effect	813:831	an important effect	813:831	Results showed that silanized NCC (SNCC) addition had an important effect on the overall properties of PLA based composite films.
32590087	5	1	theme	films	882:886	arg1	properties					848:857	the overall properties	836:857	the overall properties of PLA based composite films	836:886	Results showed that silanized NCC (SNCC) addition had an important effect on the overall properties of PLA based composite films.
32590087	1	2	theme	healthcare	241:250	arg1	applications					266:277	healthcare and packaging applications	241:277	healthcare and packaging applications	241:277	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	6	3	theme	based	1034:1038	arg1	films					1050:1054	the PLA based composite films	1026:1054	the PLA based composite films	1026:1054	The increased SNCC was found to impart improvement in air permeability, light resistance, thermal stability and mechanical properties to the PLA based composite films.
32590087	6	4	theme	increased	893:901	arg1	SNCC					903:906	The increased SNCC	889:906	The increased SNCC	889:906	The increased SNCC was found to impart improvement in air permeability, light resistance, thermal stability and mechanical properties to the PLA based composite films.
32590087	2	5	theme	various	332:338	arg1	ratios					340:345	various ratios	332:345	various ratios	332:345	In the present work, PLA and NCC were compounded at various ratios to form biocomposite films via solution casting process.
32590087	4	6	theme	as-prepared	564:574	arg1	films					594:598	The as-prepared PLA/NCC composite films	560:598	The as-prepared PLA/NCC composite films	560:598	The as-prepared PLA/NCC composite films were further characterized by using SEM, FTIR, X-ray diffraction, UV-visible spectra analysis, thermal analysis, air permeability and mechanical measurements.
32590087	9	7	theme	based	1451:1455	arg1	films					1467:1471	PLA based composite films	1447:1471	PLA based composite films	1447:1471	Therefore, this work may offer an effective route for reinforcing PLA based composite films.
32590087	7	8	from	%	1202:1202	arg1	strength					1219:1226	the tensile strength	1207:1226	the tensile strength	1207:1226	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	2	9	theme	present	287:293	arg1	work					295:298	the present work	283:298	the present work	283:298	In the present work, PLA and NCC were compounded at various ratios to form biocomposite films via solution casting process.
32590087	4	10	theme	X-ray	647:651	arg1	diffraction					653:663	X-ray diffraction	647:663	X-ray diffraction	647:663	The as-prepared PLA/NCC composite films were further characterized by using SEM, FTIR, X-ray diffraction, UV-visible spectra analysis, thermal analysis, air permeability and mechanical measurements.
32590087	4	10	theme	X-ray	647:651	arg1	SEM					636:638	SEM	636:638	SEM	636:638	The as-prepared PLA/NCC composite films were further characterized by using SEM, FTIR, X-ray diffraction, UV-visible spectra analysis, thermal analysis, air permeability and mechanical measurements.
32590087	1	11	theme	packaging	256:264	arg1	applications					266:277	healthcare and packaging applications	241:277	healthcare and packaging applications	241:277	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	7	12	theme	tensile	1211:1217	arg1	strength					1219:1226	the tensile strength	1207:1226	the tensile strength	1207:1226	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	6	13	theme	light	961:965	arg1	resistance					967:976	light resistance	961:976	light resistance	961:976	The increased SNCC was found to impart improvement in air permeability, light resistance, thermal stability and mechanical properties to the PLA based composite films.
32590087	7	14	theme	PLA	1124:1126	arg1	films					1144:1148	the obtained PLA based composite films	1111:1148	the obtained PLA based composite films with 0.5 wt % SNCC	1111:1167	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	8	15	theme	PLA/SNCC	1277:1284	arg1	films					1296:1300	PLA/SNCC composite films	1277:1300	PLA/SNCC composite films	1277:1300	Moreover, PLA/SNCC composite films exhibited a decrease of 87.9% in air permeability compared with pure PLA film.
32590087	1	16	theme	applications	266:277	arg1	range					232:236	a wide range	225:236	a wide range of healthcare and packaging applications	225:277	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	7	17	theme	%	1162:1162	arg1	SNCC					1164:1167	0.5 wt % SNCC	1155:1167	0.5 wt % SNCC	1155:1167	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	3	18	theme	blends	453:458	arg1	compatibility					428:440	the compatibility	424:440	the compatibility of PLA/NCC blends	424:458	In order to improve the compatibility of PLA/NCC blends, the NCC was deliberately subjected to graft modification by 3-aminopropyltriethoxysilane (KH-550).
32590087	7	19	dep	sample	1103:1108	arg1	comparison					1074:1083	comparison	1074:1083	comparison	1074:1083	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	1	20	theme	biodegradable	166:178	arg1	cellulose					136:144	nanocrystalline cellulose	120:144	nanocrystalline cellulose (NCC)	120:150	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	1	20	theme	biodegradable	166:178	arg1	materials					180:188	promising biodegradable materials	156:188	promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications	156:277	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	1	20	theme	biodegradable	166:178	arg1	acid					105:108	Polylactic acid	94:108	Polylactic acid (PLA)	94:114	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	4	21	theme	composite	584:592	arg1	films					594:598	The as-prepared PLA/NCC composite films	560:598	The as-prepared PLA/NCC composite films	560:598	The as-prepared PLA/NCC composite films were further characterized by using SEM, FTIR, X-ray diffraction, UV-visible spectra analysis, thermal analysis, air permeability and mechanical measurements.
32590087	4	22	theme	PLA/NCC	576:582	arg1	films					594:598	The as-prepared PLA/NCC composite films	560:598	The as-prepared PLA/NCC composite films	560:598	The as-prepared PLA/NCC composite films were further characterized by using SEM, FTIR, X-ray diffraction, UV-visible spectra analysis, thermal analysis, air permeability and mechanical measurements.
32590087	1	23	theme	Polylactic	94:103	arg1	cellulose					136:144	nanocrystalline cellulose	120:144	nanocrystalline cellulose (NCC)	120:150	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	1	23	theme	Polylactic	94:103	arg1	PLA					111:113	PLA	111:113	PLA	111:113	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	1	23	theme	Polylactic	94:103	arg1	materials					180:188	promising biodegradable materials	156:188	promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications	156:277	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	1	23	theme	Polylactic	94:103	arg1	acid					105:108	Polylactic acid	94:108	Polylactic acid (PLA)	94:114	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	0	24	theme	acid	11:14	arg1	films					35:39	Polylactic acid based biocomposite films	0:39	Polylactic acid based biocomposite films	0:39	Polylactic acid based biocomposite films reinforced with silanized nanocrystalline cellulose.
32590087	7	25	from	strength	1219:1226	arg1	increases					1176:1184	increases	1176:1184	increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively	1176:1264	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	0	26	theme	Polylactic	0:9	arg1	films					35:39	Polylactic acid based biocomposite films	0:39	Polylactic acid based biocomposite films	0:39	Polylactic acid based biocomposite films reinforced with silanized nanocrystalline cellulose.
32590087	7	27	theme	based	1128:1132	arg1	films					1144:1148	the obtained PLA based composite films	1111:1148	the obtained PLA based composite films with 0.5 wt % SNCC	1111:1167	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	5	28	theme	overall	840:846	arg1	properties					848:857	the overall properties	836:857	the overall properties of PLA based composite films	836:886	Results showed that silanized NCC (SNCC) addition had an important effect on the overall properties of PLA based composite films.
32590087	7	29	with	films	1144:1148	arg1	SNCC					1164:1167	0.5 wt % SNCC	1155:1167	0.5 wt % SNCC	1155:1167	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	6	30	theme	thermal	979:985	arg1	stability					987:995	thermal stability	979:995	thermal stability	979:995	The increased SNCC was found to impart improvement in air permeability, light resistance, thermal stability and mechanical properties to the PLA based composite films.
32590087	2	31	theme	biocomposite	355:366	arg1	films					368:372	biocomposite films	355:372	biocomposite films	355:372	In the present work, PLA and NCC were compounded at various ratios to form biocomposite films via solution casting process.
32590087	0	32	theme	biocomposite	22:33	arg1	films					35:39	Polylactic acid based biocomposite films	0:39	Polylactic acid based biocomposite films	0:39	Polylactic acid based biocomposite films reinforced with silanized nanocrystalline cellulose.
32590087	7	33	from	elongation	1232:1241	arg1	strength					1219:1226	the tensile strength	1207:1226	the tensile strength	1207:1226	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	8	34	theme	%	1330:1330	arg1	decrease					1314:1321	a decrease	1312:1321	a decrease of 87.9% in air permeability	1312:1350	Moreover, PLA/SNCC composite films exhibited a decrease of 87.9% in air permeability compared with pure PLA film.
32590087	3	35	theme	PLA/NCC	445:451	arg1	blends					453:458	PLA/NCC blends	445:458	PLA/NCC blends	445:458	In order to improve the compatibility of PLA/NCC blends, the NCC was deliberately subjected to graft modification by 3-aminopropyltriethoxysilane (KH-550).
32590087	0	36	theme	based	16:20	arg1	films					35:39	Polylactic acid based biocomposite films	0:39	Polylactic acid based biocomposite films	0:39	Polylactic acid based biocomposite films reinforced with silanized nanocrystalline cellulose.
32590087	6	37	theme	air	943:945	arg1	permeability					947:958	air permeability	943:958	air permeability	943:958	The increased SNCC was found to impart improvement in air permeability, light resistance, thermal stability and mechanical properties to the PLA based composite films.
32590087	1	38	theme	promising	156:164	arg1	cellulose					136:144	nanocrystalline cellulose	120:144	nanocrystalline cellulose (NCC)	120:150	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	1	38	theme	promising	156:164	arg1	materials					180:188	promising biodegradable materials	156:188	promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications	156:277	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	1	38	theme	promising	156:164	arg1	acid					105:108	Polylactic acid	94:108	Polylactic acid (PLA)	94:114	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	1	39	theme	great	206:210	arg1	potential					212:220	great potential	206:220	great potential	206:220	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	5	40	theme	silanized	779:787	arg1	addition					800:807	silanized NCC (SNCC) addition	779:807	silanized NCC (SNCC) addition	779:807	Results showed that silanized NCC (SNCC) addition had an important effect on the overall properties of PLA based composite films.
32590087	4	41	theme	thermal	695:701	arg1	analysis					703:710	thermal analysis	695:710	thermal analysis	695:710	The as-prepared PLA/NCC composite films were further characterized by using SEM, FTIR, X-ray diffraction, UV-visible spectra analysis, thermal analysis, air permeability and mechanical measurements.
32590087	8	42	from	decrease	1314:1321	arg1	permeability					1339:1350	air permeability	1335:1350	air permeability	1335:1350	Moreover, PLA/SNCC composite films exhibited a decrease of 87.9% in air permeability compared with pure PLA film.
32590087	5	43	contain	had	809:811	arg1	addition					800:807	silanized NCC (SNCC) addition	779:807	silanized NCC (SNCC) addition	779:807	Results showed that silanized NCC (SNCC) addition had an important effect on the overall properties of PLA based composite films.
32590087	5	43	contain	had	809:811	arg2	effect					826:831	an important effect	813:831	an important effect	813:831	Results showed that silanized NCC (SNCC) addition had an important effect on the overall properties of PLA based composite films.
32590087	8	44	theme	air	1335:1337	arg1	permeability					1339:1350	air permeability	1335:1350	air permeability	1335:1350	Moreover, PLA/SNCC composite films exhibited a decrease of 87.9% in air permeability compared with pure PLA film.
32590087	5	45	theme	PLA	862:864	arg1	films					882:886	PLA based composite films	862:886	PLA based composite films	862:886	Results showed that silanized NCC (SNCC) addition had an important effect on the overall properties of PLA based composite films.
32590087	9	46	theme	composite	1457:1465	arg1	films					1467:1471	PLA based composite films	1447:1471	PLA based composite films	1447:1471	Therefore, this work may offer an effective route for reinforcing PLA based composite films.
32590087	2	47	theme	solution	378:385	arg1	process					395:401	solution casting process	378:401	solution casting process	378:401	In the present work, PLA and NCC were compounded at various ratios to form biocomposite films via solution casting process.
32590087	5	48	theme	NCC	789:791	arg1	addition					800:807	silanized NCC (SNCC) addition	779:807	silanized NCC (SNCC) addition	779:807	Results showed that silanized NCC (SNCC) addition had an important effect on the overall properties of PLA based composite films.
32590087	7	49	theme	composite	1134:1142	arg1	films					1144:1148	the obtained PLA based composite films	1111:1148	the obtained PLA based composite films with 0.5 wt % SNCC	1111:1167	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	6	50	theme	PLA	1030:1032	arg1	films					1050:1054	the PLA based composite films	1026:1054	the PLA based composite films	1026:1054	The increased SNCC was found to impart improvement in air permeability, light resistance, thermal stability and mechanical properties to the PLA based composite films.
32590087	2	51	theme	casting	387:393	arg1	process					395:401	solution casting process	378:401	solution casting process	378:401	In the present work, PLA and NCC were compounded at various ratios to form biocomposite films via solution casting process.
32590087	0	52	theme	silanized	57:65	arg1	cellulose					83:91	silanized nanocrystalline cellulose	57:91	silanized nanocrystalline cellulose	57:91	Polylactic acid based biocomposite films reinforced with silanized nanocrystalline cellulose.
32590087	7	53	from	increases	1176:1184	arg1	strength					1219:1226	the tensile strength	1207:1226	the tensile strength	1207:1226	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	7	53	from	increases	1176:1184	arg1	break					1246:1250	break	1246:1250	break	1246:1250	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	7	54	from	break	1246:1250	arg1	increases					1176:1184	increases	1176:1184	increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively	1176:1264	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	7	54	from	break	1246:1250	arg1	%					1194:1194	53.87%	1189:1194	53.87%	1189:1194	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	7	54	from	break	1246:1250	arg1	%					1202:1202	61.46%	1197:1202	61.46% in the tensile strength	1197:1226	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	7	54	from	break	1246:1250	arg1	elongation					1232:1241	elongation	1232:1241	elongation at break	1232:1250	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	9	55	theme	effective	1415:1423	arg1	route					1425:1429	an effective route	1412:1429	an effective route for reinforcing PLA based composite films	1412:1471	Therefore, this work may offer an effective route for reinforcing PLA based composite films.
32590087	5	56	theme	SNCC	794:797	arg1	addition					800:807	silanized NCC (SNCC) addition	779:807	silanized NCC (SNCC) addition	779:807	Results showed that silanized NCC (SNCC) addition had an important effect on the overall properties of PLA based composite films.
32590087	7	57	theme	%	1202:1202	arg1	increases					1176:1184	increases	1176:1184	increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively	1176:1264	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	1	58	theme	nanocrystalline	120:134	arg1	cellulose					136:144	nanocrystalline cellulose	120:144	nanocrystalline cellulose (NCC)	120:150	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	1	58	theme	nanocrystalline	120:134	arg1	acid					105:108	Polylactic acid	94:108	Polylactic acid (PLA)	94:114	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	1	58	theme	nanocrystalline	120:134	arg1	materials					180:188	promising biodegradable materials	156:188	promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications	156:277	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	1	58	theme	nanocrystalline	120:134	arg1	NCC					147:149	NCC	147:149	NCC	147:149	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	8	59	theme	PLA	1371:1373	arg1	film					1375:1378	pure PLA film	1366:1378	pure PLA film	1366:1378	Moreover, PLA/SNCC composite films exhibited a decrease of 87.9% in air permeability compared with pure PLA film.
32590087	6	60	from	improvement	928:938	arg1	permeability					947:958	air permeability	943:958	air permeability	943:958	The increased SNCC was found to impart improvement in air permeability, light resistance, thermal stability and mechanical properties to the PLA based composite films.
32590087	6	60	from	improvement	928:938	arg1	resistance					967:976	light resistance	961:976	light resistance	961:976	The increased SNCC was found to impart improvement in air permeability, light resistance, thermal stability and mechanical properties to the PLA based composite films.
32590087	6	60	from	improvement	928:938	arg1	stability					987:995	thermal stability	979:995	thermal stability	979:995	The increased SNCC was found to impart improvement in air permeability, light resistance, thermal stability and mechanical properties to the PLA based composite films.
32590087	6	60	from	improvement	928:938	arg1	properties					1012:1021	mechanical properties	1001:1021	mechanical properties	1001:1021	The increased SNCC was found to impart improvement in air permeability, light resistance, thermal stability and mechanical properties to the PLA based composite films.
32590087	8	61	theme	pure	1366:1369	arg1	film					1375:1378	pure PLA film	1366:1378	pure PLA film	1366:1378	Moreover, PLA/SNCC composite films exhibited a decrease of 87.9% in air permeability compared with pure PLA film.
32590087	7	62	theme	obtained	1115:1122	arg1	films					1144:1148	the obtained PLA based composite films	1111:1148	the obtained PLA based composite films with 0.5 wt % SNCC	1111:1167	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	6	63	theme	mechanical	1001:1010	arg1	properties					1012:1021	mechanical properties	1001:1021	mechanical properties	1001:1021	The increased SNCC was found to impart improvement in air permeability, light resistance, thermal stability and mechanical properties to the PLA based composite films.
32590087	4	64	theme	air	713:715	arg1	permeability					717:728	air permeability	713:728	air permeability	713:728	The as-prepared PLA/NCC composite films were further characterized by using SEM, FTIR, X-ray diffraction, UV-visible spectra analysis, thermal analysis, air permeability and mechanical measurements.
32590087	7	65	from	%	1194:1194	arg1	strength					1219:1226	the tensile strength	1207:1226	the tensile strength	1207:1226	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	6	66	theme	composite	1040:1048	arg1	films					1050:1054	the PLA based composite films	1026:1054	the PLA based composite films	1026:1054	The increased SNCC was found to impart improvement in air permeability, light resistance, thermal stability and mechanical properties to the PLA based composite films.
32590087	4	67	theme	mechanical	734:743	arg1	measurements					745:756	mechanical measurements	734:756	mechanical measurements	734:756	The as-prepared PLA/NCC composite films were further characterized by using SEM, FTIR, X-ray diffraction, UV-visible spectra analysis, thermal analysis, air permeability and mechanical measurements.
32590087	4	68	theme	UV-visible	666:675	arg1	spectra					677:683	UV-visible spectra	666:683	UV-visible spectra	666:683	The as-prepared PLA/NCC composite films were further characterized by using SEM, FTIR, X-ray diffraction, UV-visible spectra analysis, thermal analysis, air permeability and mechanical measurements.
32590087	4	68	theme	UV-visible	666:675	arg1	SEM					636:638	SEM	636:638	SEM	636:638	The as-prepared PLA/NCC composite films were further characterized by using SEM, FTIR, X-ray diffraction, UV-visible spectra analysis, thermal analysis, air permeability and mechanical measurements.
32590087	8	69	theme	composite	1286:1294	arg1	films					1296:1300	PLA/SNCC composite films	1277:1300	PLA/SNCC composite films	1277:1300	Moreover, PLA/SNCC composite films exhibited a decrease of 87.9% in air permeability compared with pure PLA film.
32590087	1	70	theme	wide	227:230	arg1	range					232:236	a wide range	225:236	a wide range of healthcare and packaging applications	225:277	Polylactic acid (PLA) and nanocrystalline cellulose (NCC) are promising biodegradable materials that have shown great potential in a wide range of healthcare and packaging applications.
32590087	7	71	theme	%	1194:1194	arg1	increases					1176:1184	increases	1176:1184	increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively	1176:1264	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	5	72	theme	composite	872:880	arg1	films					882:886	PLA based composite films	862:886	PLA based composite films	862:886	Results showed that silanized NCC (SNCC) addition had an important effect on the overall properties of PLA based composite films.
32590087	4	73	theme	SEM	636:638	arg1	analysis					685:692	SEM, FTIR, X-ray diffraction, UV-visible spectra analysis	636:692	SEM, FTIR, X-ray diffraction, UV-visible spectra analysis	636:692	The as-prepared PLA/NCC composite films were further characterized by using SEM, FTIR, X-ray diffraction, UV-visible spectra analysis, thermal analysis, air permeability and mechanical measurements.
32590087	5	74	theme	based	866:870	arg1	films					882:886	PLA based composite films	862:886	PLA based composite films	862:886	Results showed that silanized NCC (SNCC) addition had an important effect on the overall properties of PLA based composite films.
32590087	0	75	theme	nanocrystalline	67:81	arg1	cellulose					83:91	silanized nanocrystalline cellulose	57:91	silanized nanocrystalline cellulose	57:91	Polylactic acid based biocomposite films reinforced with silanized nanocrystalline cellulose.
32590087	7	76	theme	elongation	1232:1241	arg1	increases					1176:1184	increases	1176:1184	increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively	1176:1264	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	3	77	theme	graft	499:503	arg1	modification					505:516	graft modification	499:516	graft modification	499:516	In order to improve the compatibility of PLA/NCC blends, the NCC was deliberately subjected to graft modification by 3-aminopropyltriethoxysilane (KH-550).
32590087	7	78	theme	0.5 wt	1155:1160	arg1	SNCC					1164:1167	0.5 wt % SNCC	1155:1167	0.5 wt % SNCC	1155:1167	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
32590087	7	79	theme	controlled	1092:1101	arg1	sample					1103:1108	the controlled sample	1088:1108	the controlled sample	1088:1108	Particularly, in comparison to the controlled sample, the obtained PLA based composite films with 0.5 wt % SNCC showed increases of 53.87%, 61.46% in the tensile strength and elongation at break, respectively.
34699666	0	0	theme	Wearable	98:105	arg1	Sensor					107:112	Smart Wearable Sensor	92:112	Smart Wearable Sensor	92:112	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid Metal by Facile Synthesis for Smart Wearable Sensor.
34699666	10	1	theme	great	1470:1474	arg1	scope					1476:1480	a great scope	1468:1480	a great scope for researchers to achieve practical advances in smart wearable sensors	1468:1552	All these properties provide a great scope for researchers to achieve practical advances in smart wearable sensors.
34699666	8	2	theme	different	1264:1272	arg1	stress					1274:1279	different stress and temperature stimuli	1264:1303	stress	1274:1279	Importantly, the composite hydrogel simultaneous response to different stress and temperature stimuli.
34699666	9	3	from	manipulator	1396:1406	arg1	interaction					1426:1436	human-computer interaction	1411:1436	human-computer interaction	1411:1436	Furthermore, the CHACC-LM hydrogel can be used for gesture recognition and to control the manipulator in human-computer interaction.
34699666	9	4	theme	human-computer	1411:1424	arg1	interaction					1426:1436	human-computer interaction	1411:1436	human-computer interaction	1411:1436	Furthermore, the CHACC-LM hydrogel can be used for gesture recognition and to control the manipulator in human-computer interaction.
34699666	0	5	theme	Smart	92:96	arg1	Sensor					107:112	Smart Wearable Sensor	92:112	Smart Wearable Sensor	92:112	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid Metal by Facile Synthesis for Smart Wearable Sensor.
34699666	7	6	from	sensitivity	1100:1110	arg1	environment					1128:1138	the external environment	1115:1138	the external environment such as low temperature, thermal response, and water solution	1115:1200	It also shows sensitivity in the external environment such as low temperature, thermal response, and water solution.
34699666	7	7	theme	external	1119:1126	arg1	environment					1128:1138	the external environment	1115:1138	the external environment such as low temperature, thermal response, and water solution	1115:1200	It also shows sensitivity in the external environment such as low temperature, thermal response, and water solution.
34699666	1	8	theme	promising	180:188	arg1	applications					190:201	their promising applications	174:201	their promising applications in wearable sensors	174:221	Conductive hydrogels have attracted great attention due to their promising applications in wearable sensors.
34699666	4	9	theme	hydrogel	627:634	arg1	1.11 MPa					652:659	stress: 1.11 MPa	644:659	stress: 1.11 MPa	644:659	LM as liquid fillers toughen the hydrogel matrix (stress: 1.11 MPa) and enhance the hydrogel extensibility (strain: 233%).
34699666	4	9	theme	hydrogel	627:634	arg1	matrix					636:641	the hydrogel matrix	623:641	the hydrogel matrix (stress: 1.11 MPa)	623:660	LM as liquid fillers toughen the hydrogel matrix (stress: 1.11 MPa) and enhance the hydrogel extensibility (strain: 233%).
34699666	7	10	theme	water	1187:1191	arg1	solution					1193:1200	water solution	1187:1200	water solution	1187:1200	It also shows sensitivity in the external environment such as low temperature, thermal response, and water solution.
34699666	6	11	theme	CHACC-LM	896:903	arg1	hydrogel					905:912	the CHACC-LM hydrogel	892:912	the CHACC-LM hydrogel	892:912	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	6	11	theme	CHACC-LM	896:903	arg1	sensors					947:953	wearable flexible sensors	929:953	wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting)	929:1083	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	2	12	theme	smart	338:342	arg1	devices					353:359	smart wearable devices	338:359	smart wearable devices	338:359	However, developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices is still a challenge.
34699666	4	13	theme	strain	702:707	arg1	%					713:713	strain: 233%	702:713	strain: 233%	702:713	LM as liquid fillers toughen the hydrogel matrix (stress: 1.11 MPa) and enhance the hydrogel extensibility (strain: 233%).
34699666	4	13	theme	strain	702:707	arg1	extensibility					687:699	the hydrogel extensibility	674:699	the hydrogel extensibility (strain: 233%)	674:714	LM as liquid fillers toughen the hydrogel matrix (stress: 1.11 MPa) and enhance the hydrogel extensibility (strain: 233%).
34699666	4	14	theme	stress	644:649	arg1	1.11 MPa					652:659	stress: 1.11 MPa	644:659	stress: 1.11 MPa	644:659	LM as liquid fillers toughen the hydrogel matrix (stress: 1.11 MPa) and enhance the hydrogel extensibility (strain: 233%).
34699666	4	14	theme	stress	644:649	arg1	matrix					636:641	the hydrogel matrix	623:641	the hydrogel matrix (stress: 1.11 MPa)	623:660	LM as liquid fillers toughen the hydrogel matrix (stress: 1.11 MPa) and enhance the hydrogel extensibility (strain: 233%).
34699666	3	15	theme	facile	405:410	arg1	method					422:427	a facile synthetic method	403:427	a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor	403:591	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	6	16	with	sensors	947:953	arg1	ability					1034:1040	the distinguished ability	1016:1040	the distinguished ability of discerning subtle motions (handwriting)	1016:1083	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	6	16	with	sensors	947:953	arg1	ability					964:970	the ability	960:970	the ability of monitoring human activities directly	960:1010	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	5	17	theme	=	871:871	arg1	GF					868:869	GF = 1.6	868:875	GF = 1.6	868:875	The CHACC-LM hydrogel exhibits conductivity , excellent antibacterial properties (> 99%), an electrical self-healing property, and strain sensitivity (GF = 1.6).
34699666	5	17	theme	=	871:871	arg1	sensitivity					855:865	strain sensitivity	848:865	strain sensitivity (GF = 1.6)	848:876	The CHACC-LM hydrogel exhibits conductivity , excellent antibacterial properties (> 99%), an electrical self-healing property, and strain sensitivity (GF = 1.6).
34699666	5	18	theme	antibacterial	773:785	arg1	properties					787:796	excellent antibacterial properties	763:796	excellent antibacterial properties (> 99%)	763:804	The CHACC-LM hydrogel exhibits conductivity , excellent antibacterial properties (> 99%), an electrical self-healing property, and strain sensitivity (GF = 1.6).
34699666	5	18	theme	antibacterial	773:785	arg1	%					803:803	> 99%	799:803	> 99%	799:803	The CHACC-LM hydrogel exhibits conductivity , excellent antibacterial properties (> 99%), an electrical self-healing property, and strain sensitivity (GF = 1.6).
34699666	3	19	with	hydrogel	518:525	arg1	sensing					559:565	temperature-stress bimodal sensing	532:565	temperature-stress bimodal sensing	532:565	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	5	20	theme	self-healing	821:832	arg1	property					834:841	an electrical self-healing property	807:841	an electrical self-healing property	807:841	The CHACC-LM hydrogel exhibits conductivity , excellent antibacterial properties (> 99%), an electrical self-healing property, and strain sensitivity (GF = 1.6).
34699666	3	21	theme	salt	475:478	arg1	method					422:427	a facile synthetic method	403:427	a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor	403:591	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	3	22	theme	liquid	484:489	arg1	hydrogel					518:525	liquid metal (CHACC-LM) composite hydrogel	484:525	liquid metal (CHACC-LM) composite hydrogel	484:525	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	5	23	theme	electrical	810:819	arg1	property					834:841	an electrical self-healing property	807:841	an electrical self-healing property	807:841	The CHACC-LM hydrogel exhibits conductivity , excellent antibacterial properties (> 99%), an electrical self-healing property, and strain sensitivity (GF = 1.6).
34699666	9	24	theme	CHACC-LM	1323:1330	arg1	hydrogel					1332:1339	the CHACC-LM hydrogel	1319:1339	the CHACC-LM hydrogel	1319:1339	Furthermore, the CHACC-LM hydrogel can be used for gesture recognition and to control the manipulator in human-computer interaction.
34699666	2	25	theme	stimuli	311:317	arg1	responsiveness					319:332	multiple stimuli responsiveness	302:332	multiple stimuli responsiveness	302:332	However, developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices is still a challenge.
34699666	3	26	theme	metal	491:495	arg1	hydrogel					518:525	liquid metal (CHACC-LM) composite hydrogel	484:525	liquid metal (CHACC-LM) composite hydrogel	484:525	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	0	27	theme	Bimodal	19:25	arg1	Hydrogel-Liquid					46:60	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid	0:60	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid	0:60	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid Metal by Facile Synthesis for Smart Wearable Sensor.
34699666	7	28	theme	thermal	1165:1171	arg1	response					1173:1180	thermal response	1165:1180	thermal response	1165:1180	It also shows sensitivity in the external environment such as low temperature, thermal response, and water solution.
34699666	1	29	theme	wearable	206:213	arg1	sensors					215:221	wearable sensors	206:221	wearable sensors	206:221	Conductive hydrogels have attracted great attention due to their promising applications in wearable sensors.
34699666	0	30	theme	Temperature-Stress	0:17	arg1	Hydrogel-Liquid					46:60	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid	0:60	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid	0:60	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid Metal by Facile Synthesis for Smart Wearable Sensor.
34699666	2	31	with	hydrogels	255:263	arg1	properties					287:296	excellent sensor properties	270:296	excellent sensor properties	270:296	However, developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices is still a challenge.
34699666	2	31	with	hydrogels	255:263	arg1	responsiveness					319:332	multiple stimuli responsiveness	302:332	multiple stimuli responsiveness	302:332	However, developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices is still a challenge.
34699666	8	32	theme	hydrogel	1230:1237	arg1	response					1252:1259	the composite hydrogel simultaneous response	1216:1259	the composite hydrogel simultaneous response to different stress and temperature stimuli	1216:1303	Importantly, the composite hydrogel simultaneous response to different stress and temperature stimuli.
34699666	10	33	theme	wearable	1537:1544	arg1	sensors					1546:1552	smart wearable sensors	1531:1552	smart wearable sensors	1531:1552	All these properties provide a great scope for researchers to achieve practical advances in smart wearable sensors.
34699666	8	34	theme	simultaneous	1239:1250	arg1	response					1252:1259	the composite hydrogel simultaneous response	1216:1259	the composite hydrogel simultaneous response to different stress and temperature stimuli	1216:1303	Importantly, the composite hydrogel simultaneous response to different stress and temperature stimuli.
34699666	0	35	theme	Conductive	35:44	arg1	Hydrogel-Liquid					46:60	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid	0:60	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid	0:60	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid Metal by Facile Synthesis for Smart Wearable Sensor.
34699666	4	36	theme	liquid	600:605	arg1	fillers					607:613	liquid fillers	600:613	liquid fillers	600:613	LM as liquid fillers toughen the hydrogel matrix (stress: 1.11 MPa) and enhance the hydrogel extensibility (strain: 233%).
34699666	5	37	theme	CHACC-LM	721:728	arg1	hydrogel					730:737	The CHACC-LM hydrogel	717:737	The CHACC-LM hydrogel	717:737	The CHACC-LM hydrogel exhibits conductivity , excellent antibacterial properties (> 99%), an electrical self-healing property, and strain sensitivity (GF = 1.6).
34699666	1	38	theme	Conductive	115:124	arg1	hydrogels					126:134	Conductive hydrogels	115:134	Conductive hydrogels	115:134	Conductive hydrogels have attracted great attention due to their promising applications in wearable sensors.
34699666	2	39	theme	excellent	270:278	arg1	properties					287:296	excellent sensor properties	270:296	excellent sensor properties	270:296	However, developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices is still a challenge.
34699666	5	40	theme	strain	848:853	arg1	GF					868:869	GF = 1.6	868:875	GF = 1.6	868:875	The CHACC-LM hydrogel exhibits conductivity , excellent antibacterial properties (> 99%), an electrical self-healing property, and strain sensitivity (GF = 1.6).
34699666	5	40	theme	strain	848:853	arg1	sensitivity					855:865	strain sensitivity	848:865	strain sensitivity (GF = 1.6)	848:876	The CHACC-LM hydrogel exhibits conductivity , excellent antibacterial properties (> 99%), an electrical self-healing property, and strain sensitivity (GF = 1.6).
34699666	0	41	theme	Sensing	27:33	arg1	Hydrogel-Liquid					46:60	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid	0:60	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid	0:60	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid Metal by Facile Synthesis for Smart Wearable Sensor.
34699666	10	42	theme	practical	1509:1517	arg1	advances					1519:1526	practical advances	1509:1526	practical advances in smart wearable sensors	1509:1552	All these properties provide a great scope for researchers to achieve practical advances in smart wearable sensors.
34699666	2	43	theme	wearable	344:351	arg1	devices					353:359	smart wearable devices	338:359	smart wearable devices	338:359	However, developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices is still a challenge.
34699666	7	44	theme	low	1148:1150	arg1	temperature					1152:1162	low temperature	1148:1162	low temperature	1148:1162	It also shows sensitivity in the external environment such as low temperature, thermal response, and water solution.
34699666	3	45	theme	composite	508:516	arg1	hydrogel					518:525	liquid metal (CHACC-LM) composite hydrogel	484:525	liquid metal (CHACC-LM) composite hydrogel	484:525	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	3	46	theme	quaternary	455:464	arg1	ammonium					466:473	chitosan quaternary ammonium	446:473	chitosan quaternary ammonium salt	446:478	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	8	47	theme	temperature	1285:1295	arg1	stimuli					1297:1303	different stress and temperature stimuli	1264:1303	stimuli	1297:1303	Importantly, the composite hydrogel simultaneous response to different stress and temperature stimuli.
34699666	3	48	link	crosslinked	434:444	arg1	salt					475:478	chitosan quaternary ammonium salt	446:478	chitosan quaternary ammonium salt	446:478	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	3	49	theme	ammonium	466:473	arg1	salt					475:478	chitosan quaternary ammonium salt	446:478	chitosan quaternary ammonium salt	446:478	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	6	50	theme	flexible	938:945	arg1	hydrogel					905:912	the CHACC-LM hydrogel	892:912	the CHACC-LM hydrogel	892:912	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	6	50	theme	flexible	938:945	arg1	sensors					947:953	wearable flexible sensors	929:953	wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting)	929:1083	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	6	51	theme	human	986:990	arg1	activities					992:1001	human activities	986:1001	human activities	986:1001	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	3	52	theme	synthetic	412:420	arg1	method					422:427	a facile synthetic method	403:427	a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor	403:591	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	3	53	theme	CHACC-LM	498:505	arg1	hydrogel					518:525	liquid metal (CHACC-LM) composite hydrogel	484:525	liquid metal (CHACC-LM) composite hydrogel	484:525	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	0	54	theme	Facile	71:76	arg1	Synthesis					78:86	Facile Synthesis	71:86	Facile Synthesis	71:86	Temperature-Stress Bimodal Sensing Conductive Hydrogel-Liquid Metal by Facile Synthesis for Smart Wearable Sensor.
34699666	6	55	theme	wearable	929:936	arg1	hydrogel					905:912	the CHACC-LM hydrogel	892:912	the CHACC-LM hydrogel	892:912	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	6	55	theme	wearable	929:936	arg1	sensors					947:953	wearable flexible sensors	929:953	wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting)	929:1083	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	3	56	with	salt	475:478	arg1	sensing					559:565	temperature-stress bimodal sensing	532:565	temperature-stress bimodal sensing	532:565	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	3	57	theme	temperature-stress	532:549	arg1	sensing					559:565	temperature-stress bimodal sensing	532:565	temperature-stress bimodal sensing	532:565	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	3	58	theme	chitosan	446:453	arg1	ammonium					466:473	chitosan quaternary ammonium	446:473	chitosan quaternary ammonium salt	446:478	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	6	59	used	used	921:924	arg2	hydrogel					905:912	the CHACC-LM hydrogel	892:912	the CHACC-LM hydrogel	892:912	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	6	59	used	used	921:924	arg2	sensors					947:953	wearable flexible sensors	929:953	wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting)	929:1083	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	2	60	theme	developing	233:242	arg1	hydrogels					255:263	developing conductive hydrogels	233:263	developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices	233:359	However, developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices is still a challenge.
34699666	2	60	theme	developing	233:242	arg1	challenge					372:380	a challenge	370:380	a challenge	370:380	However, developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices is still a challenge.
34699666	2	61	theme	conductive	244:253	arg1	hydrogels					255:263	developing conductive hydrogels	233:263	developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices	233:359	However, developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices is still a challenge.
34699666	2	61	theme	conductive	244:253	arg1	challenge					372:380	a challenge	370:380	a challenge	370:380	However, developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices is still a challenge.
34699666	3	62	theme	bimodal	551:557	arg1	sensing					559:565	temperature-stress bimodal sensing	532:565	temperature-stress bimodal sensing	532:565	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	10	63	theme	smart	1531:1535	arg1	sensors					1546:1552	smart wearable sensors	1531:1552	smart wearable sensors	1531:1552	All these properties provide a great scope for researchers to achieve practical advances in smart wearable sensors.
34699666	2	64	theme	multiple	302:309	arg1	stimuli					311:317	multiple stimuli	302:317	multiple stimuli responsiveness	302:332	However, developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices is still a challenge.
34699666	1	65	theme	great	151:155	arg1	attention					157:165	great attention	151:165	great attention	151:165	Conductive hydrogels have attracted great attention due to their promising applications in wearable sensors.
34699666	6	66	theme	distinguished	1020:1032	arg1	ability					1034:1040	the distinguished ability	1016:1040	the distinguished ability of discerning subtle motions (handwriting)	1016:1083	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	9	67	theme	gesture	1357:1363	arg1	recognition					1365:1375	gesture recognition	1357:1375	gesture recognition	1357:1375	Furthermore, the CHACC-LM hydrogel can be used for gesture recognition and to control the manipulator in human-computer interaction.
34699666	3	68	theme	hydrogel	518:525	arg1	method					422:427	a facile synthetic method	403:427	a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor	403:591	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	4	69	theme	hydrogel	678:685	arg1	%					713:713	strain: 233%	702:713	strain: 233%	702:713	LM as liquid fillers toughen the hydrogel matrix (stress: 1.11 MPa) and enhance the hydrogel extensibility (strain: 233%).
34699666	4	69	theme	hydrogel	678:685	arg1	extensibility					687:699	the hydrogel extensibility	674:699	the hydrogel extensibility (strain: 233%)	674:714	LM as liquid fillers toughen the hydrogel matrix (stress: 1.11 MPa) and enhance the hydrogel extensibility (strain: 233%).
34699666	6	70	theme	subtle	1056:1061	arg1	handwriting					1072:1082	handwriting	1072:1082	handwriting	1072:1082	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	6	70	theme	subtle	1056:1061	arg1	motions					1063:1069	subtle motions	1056:1069	subtle motions (handwriting)	1056:1083	In addition, the CHACC-LM hydrogel can be used as wearable flexible sensors with the ability of monitoring human activities directly and the distinguished ability of discerning subtle motions (handwriting).
34699666	9	71	used	used	1348:1351	arg2	hydrogel					1332:1339	the CHACC-LM hydrogel	1319:1339	the CHACC-LM hydrogel	1319:1339	Furthermore, the CHACC-LM hydrogel can be used for gesture recognition and to control the manipulator in human-computer interaction.
34699666	8	72	theme	composite	1220:1228	arg1	response					1252:1259	the composite hydrogel simultaneous response	1216:1259	the composite hydrogel simultaneous response to different stress and temperature stimuli	1216:1303	Importantly, the composite hydrogel simultaneous response to different stress and temperature stimuli.
34699666	10	73	from	advances	1519:1526	arg1	sensors					1546:1552	smart wearable sensors	1531:1552	smart wearable sensors	1531:1552	All these properties provide a great scope for researchers to achieve practical advances in smart wearable sensors.
34699666	3	74	theme	crosslinked	434:444	arg1	salt					475:478	chitosan quaternary ammonium salt	446:478	chitosan quaternary ammonium salt	446:478	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	2	75	theme	sensor	280:285	arg1	properties					287:296	excellent sensor properties	270:296	excellent sensor properties	270:296	However, developing conductive hydrogels with excellent sensor properties and multiple stimuli responsiveness for smart wearable devices is still a challenge.
34699666	1	76	from	applications	190:201	arg1	sensors					215:221	wearable sensors	206:221	wearable sensors	206:221	Conductive hydrogels have attracted great attention due to their promising applications in wearable sensors.
34699666	3	77	theme	wearable	577:584	arg1	sensor					586:591	smart wearable sensor	571:591	smart wearable sensor	571:591	This paper presents a facile synthetic method of a crosslinked chitosan quaternary ammonium salt and liquid metal (CHACC-LM) composite hydrogel with temperature-stress bimodal sensing for smart wearable sensor.
34699666	5	78	theme	excellent	763:771	arg1	properties					787:796	excellent antibacterial properties	763:796	excellent antibacterial properties (> 99%)	763:804	The CHACC-LM hydrogel exhibits conductivity , excellent antibacterial properties (> 99%), an electrical self-healing property, and strain sensitivity (GF = 1.6).
34699666	5	78	theme	excellent	763:771	arg1	%					803:803	> 99%	799:803	> 99%	799:803	The CHACC-LM hydrogel exhibits conductivity , excellent antibacterial properties (> 99%), an electrical self-healing property, and strain sensitivity (GF = 1.6).
33293794	6	0	theme	FT-IR	765:769	arg1	studies					851:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies	765:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies	765:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies were carried out.
33293794	12	1	from	variation	1648:1656	arg1	parameters					1677:1686	pharmacokinetic parameters	1661:1686	pharmacokinetic parameters	1661:1686	The optimized formula and a sustained-release marketed product were subjected to in vivo studies in rabbits and the results of the t-test demonstrated insignificant variation in pharmacokinetic parameters among the two formulations, confirming that the prepared tablet showed sustained-release profile.
33293794	3	2	theme	independent	472:482	arg1	gums					445:448	The two gums	437:448	The two gums	437:448	The two gums have been selected as independent variables.
33293794	3	2	theme	independent	472:482	arg1	variables					484:492	independent variables	472:492	independent variables	472:492	The two gums have been selected as independent variables.
33293794	13	3	theme	sustained-release	1888:1904	arg1	tablets					1906:1912	sustained-release tablets	1888:1912	sustained-release tablets	1888:1912	CONCLUSION The results indicated that karaya and locust bean gum can be effectively used to formulate sustained-release tablets.
33293794	4	4	theme	1st	560:562	arg1	Y1					570:571	Y1	570:571	Y1	570:571	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	4	theme	1st	560:562	arg1	hour					564:567	1st hour	560:567	1st hour (Y1)	560:572	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	12	5	theme	t-test	1614:1619	arg1	results					1599:1605	the results	1595:1605	the results of the t-test	1595:1619	The optimized formula and a sustained-release marketed product were subjected to in vivo studies in rabbits and the results of the t-test demonstrated insignificant variation in pharmacokinetic parameters among the two formulations, confirming that the prepared tablet showed sustained-release profile.
33293794	8	6	theme	DSC	1051:1053	arg1	results					1055:1061	FT-IR and DSC results	1041:1061	FT-IR and DSC results	1041:1061	FT-IR and DSC results confirm drug-polymer compatibility.
33293794	4	7	dep	released	677:684	arg1	%					690:690	T50%	687:690	T50%	687:690	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	7	dep	released	677:684	arg1	drug					672:675	the total drug	662:675	the total drug released (T50%)	662:691	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	1	8	theme	matrix-forming	230:243	arg1	polymers					245:252	matrix-forming polymers	230:252	matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug	230:328	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	1	8	theme	matrix-forming	230:243	arg1	efficacy					173:180	the efficacy	169:180	the efficacy of natural gums, karaya and locust bean gum,	169:225	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	11	9	theme	surface	1407:1413	arg1	methodology					1415:1425	the response surface methodology	1394:1425	the response surface methodology	1394:1425	The optimized formula generated by the response surface methodology was evaluated both for in vitro and in vivo properties.
33293794	6	10	theme	swelling-erosion	799:814	arg1	investigations					816:829	swelling-erosion investigations	799:829	swelling-erosion investigations	799:829	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies were carried out.
33293794	11	11	dep	in	1463:1464	arg1	vivo					1466:1469	vivo	1466:1469	vivo	1466:1469	The optimized formula generated by the response surface methodology was evaluated both for in vitro and in vivo properties.
33293794	0	12	theme	in	103:104	arg1	Evaluation					111:120	in vitro and in vivo Evaluation	90:120	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.	0:121	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	6	13	theme	dissolution	786:796	arg1	studies					851:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies	765:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies	765:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies were carried out.
33293794	11	14	dep	properties	1471:1480	arg1	both					1441:1444	both	1441:1444	both	1441:1444	The optimized formula generated by the response surface methodology was evaluated both for in vitro and in vivo properties.
33293794	4	15	theme	drug	585:588	arg1	exponent					626:633	diffusion exponent	616:633	diffusion exponent (Y3)	616:638	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	15	theme	drug	585:588	arg1	amount					575:580	amount	575:580	amount of drug released after 12 h (Y2)	575:613	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	15	theme	drug	585:588	arg1	Y3					636:637	Y3	636:637	Y3	636:637	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	15	theme	drug	585:588	arg1	drug					585:588	drug	585:588	drug	585:588	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	15	theme	drug	585:588	arg1	amount					533:538	the amount	529:538	the amount of drug released in 1st hour (Y1)	529:572	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	15	theme	drug	585:588	arg1	factors					509:515	The dependent factors	495:515	The dependent factors chosen	495:522	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	15	theme	drug	585:588	arg1	drug					543:546	drug	543:546	drug	543:546	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	15	theme	drug	585:588	arg1	time					645:648	time	645:648	time	645:648	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	1	16	theme	gums	193:196	arg1	polymers					245:252	matrix-forming polymers	230:252	matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug	230:328	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	1	16	theme	gums	193:196	arg1	efficacy					173:180	the efficacy	169:180	the efficacy of natural gums, karaya and locust bean gum,	169:225	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	8	17	theme	FT-IR	1041:1045	arg1	results					1055:1061	FT-IR and DSC results	1041:1061	FT-IR and DSC results	1041:1061	FT-IR and DSC results confirm drug-polymer compatibility.
33293794	6	18	theme	in	777:778	arg1	dissolution					786:796	in vitro dissolution	777:796	in vitro dissolution	777:796	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies were carried out.
33293794	6	19	dep	in	777:778	arg1	vitro					780:784	vitro	780:784	vitro	780:784	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies were carried out.
33293794	6	20	theme	DSC	772:774	arg1	studies					851:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies	765:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies	765:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies were carried out.
33293794	6	21	theme	stability	841:849	arg1	studies					851:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies	765:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies	765:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies were carried out.
33293794	0	22	theme	Surface	69:75	arg1	Methodology					77:87	Response Surface Methodology	60:87	Response Surface Methodology	60:87	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	0	23	dep	in	103:104	arg1	vivo					106:109	vivo	106:109	vivo	106:109	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	0	24	from	Modulation	0:9	arg1	Matrices					48:55	Natural Polymer Matrices	32:55	Natural Polymer Matrices	32:55	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	1	25	theme	model	319:323	arg1	drug					325:328	a model drug	317:328	a model drug	317:328	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	1	25	theme	model	319:323	arg1	diltiazem					306:314	diltiazem	306:314	diltiazem	306:314	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	7	26	from	quantity	1007:1014	arg1	tablet					1033:1038	the tablet	1029:1038	the tablet	1029:1038	RESULTS AND DISCUSSION It was evident that the release pattern from the prepared formulations was significantly influenced by the quantity of gum(s) in the tablet.
33293794	2	27	dep	METHODS	331:337	arg1	adopted					368:374	adopted	368:374	was adopted for the formulation and optimization of tablet formulations	364:434	METHODS Central design composite was adopted for the formulation and optimization of tablet formulations.
33293794	7	28	theme	s	1023:1023	arg1	quantity					1007:1014	the quantity	1003:1014	the quantity of gum(s) in the tablet	1003:1038	RESULTS AND DISCUSSION It was evident that the release pattern from the prepared formulations was significantly influenced by the quantity of gum(s) in the tablet.
33293794	9	29	used	used	1125:1128	arg2	equations					1110:1118	Polynomial equations	1099:1118	Polynomial equations	1099:1118	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	12	30	theme	marketed	1529:1536	arg1	product					1538:1544	a sustained-release marketed product	1509:1544	a sustained-release marketed product	1509:1544	The optimized formula and a sustained-release marketed product were subjected to in vivo studies in rabbits and the results of the t-test demonstrated insignificant variation in pharmacokinetic parameters among the two formulations, confirming that the prepared tablet showed sustained-release profile.
33293794	2	31	theme	tablet	416:421	arg1	formulations					423:434	tablet formulations	416:434	tablet formulations	416:434	METHODS Central design composite was adopted for the formulation and optimization of tablet formulations.
33293794	10	32	theme	constrained	1304:1314	arg1	optimization					1316:1327	constrained optimization	1304:1327	constrained optimization	1304:1327	After ANOVA analysis, the significant factors were considered for constrained optimization to get the optimized formula.
33293794	2	33	theme	design	347:352	arg1	composite					354:362	Central design composite	339:362	Central design composite	339:362	METHODS Central design composite was adopted for the formulation and optimization of tablet formulations.
33293794	7	34	theme	gum	1019:1021	arg1	s					1023:1023	gum(s)	1019:1024	gum(s)	1019:1024	RESULTS AND DISCUSSION It was evident that the release pattern from the prepared formulations was significantly influenced by the quantity of gum(s) in the tablet.
33293794	9	35	theme	impact	1165:1170	arg1	prediction					1138:1147	the prediction	1134:1147	the prediction of quantitative impact of independent factors at different levels on response variables	1134:1235	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	1	36	dep	PURPOSE	123:129	arg1	aimed					148:152	aimed	148:152	aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug	148:328	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	0	37	theme	Drug	14:17	arg1	Release					19:25	Drug Release	14:25	Drug Release from Natural Polymer Matrices	14:55	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	9	38	theme	independent	1175:1185	arg1	factors					1187:1193	independent factors	1175:1193	independent factors	1175:1193	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	2	39	dep	formulation	384:394	arg1	the					380:382	the	380:382	the	380:382	METHODS Central design composite was adopted for the formulation and optimization of tablet formulations.
33293794	0	40	theme	Polymer	40:46	arg1	Matrices					48:55	Natural Polymer Matrices	32:55	Natural Polymer Matrices	32:55	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	1	41	theme	sustained-release	277:293	arg1	tablets					295:301	sustained-release tablets	277:301	sustained-release tablets of diltiazem, a model drug	277:328	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	7	42	from	formulations	958:969	arg1	pattern					932:938	the release pattern	920:938	the release pattern from the prepared formulations	920:969	RESULTS AND DISCUSSION It was evident that the release pattern from the prepared formulations was significantly influenced by the quantity of gum(s) in the tablet.
33293794	4	43	theme	drug	672:675	arg1	half					654:657	half	654:657	half of the total drug released (T50%)	654:691	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	9	44	theme	response	1218:1225	arg1	variables					1227:1235	response variables	1218:1235	response variables	1218:1235	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	9	45	from	variables	1227:1235	arg1	prediction					1138:1147	the prediction	1134:1147	the prediction of quantitative impact of independent factors at different levels on response variables	1134:1235	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	7	46	dep	DISCUSSION	889:898	arg1	It					900:901	It	900:901	It	900:901	RESULTS AND DISCUSSION It was evident that the release pattern from the prepared formulations was significantly influenced by the quantity of gum(s) in the tablet.
33293794	0	47	dep	Modulation	0:9	arg1	Evaluation					111:120	in vitro and in vivo Evaluation	90:120	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.	0:121	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	12	48	theme	pharmacokinetic	1661:1675	arg1	parameters					1677:1686	pharmacokinetic parameters	1661:1686	pharmacokinetic parameters	1661:1686	The optimized formula and a sustained-release marketed product were subjected to in vivo studies in rabbits and the results of the t-test demonstrated insignificant variation in pharmacokinetic parameters among the two formulations, confirming that the prepared tablet showed sustained-release profile.
33293794	7	49	theme	prepared	949:956	arg1	formulations					958:969	the prepared formulations	945:969	the prepared formulations	945:969	RESULTS AND DISCUSSION It was evident that the release pattern from the prepared formulations was significantly influenced by the quantity of gum(s) in the tablet.
33293794	11	50	theme	in	1463:1464	arg1	properties					1471:1480	in vitro and in vivo properties	1450:1480	in vitro and in vivo properties	1450:1480	The optimized formula generated by the response surface methodology was evaluated both for in vitro and in vivo properties.
33293794	1	51	theme	bean	217:220	arg1	gum					222:224	locust bean gum	210:224	locust bean gum	210:224	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	1	51	theme	bean	217:220	arg1	gums					193:196	natural gums	185:196	natural gums	185:196	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	4	52	theme	drug	543:546	arg1	exponent					626:633	diffusion exponent	616:633	diffusion exponent (Y3)	616:638	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	52	theme	drug	543:546	arg1	amount					575:580	amount	575:580	amount of drug released after 12 h (Y2)	575:613	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	52	theme	drug	543:546	arg1	Y3					636:637	Y3	636:637	Y3	636:637	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	52	theme	drug	543:546	arg1	drug					585:588	drug	585:588	drug	585:588	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	52	theme	drug	543:546	arg1	amount					533:538	the amount	529:538	the amount of drug released in 1st hour (Y1)	529:572	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	52	theme	drug	543:546	arg1	factors					509:515	The dependent factors	495:515	The dependent factors chosen	495:522	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	52	theme	drug	543:546	arg1	drug					543:546	drug	543:546	drug	543:546	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	52	theme	drug	543:546	arg1	time					645:648	time	645:648	time	645:648	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	13	53	dep	CONCLUSION	1786:1795	arg1	indicated					1809:1817	indicated	1809:1817	indicated that karaya and locust bean gum can be effectively used to formulate sustained-release tablets	1809:1912	CONCLUSION The results indicated that karaya and locust bean gum can be effectively used to formulate sustained-release tablets.
33293794	11	54	theme	response	1398:1405	arg1	methodology					1415:1425	the response surface methodology	1394:1425	the response surface methodology	1394:1425	The optimized formula generated by the response surface methodology was evaluated both for in vitro and in vivo properties.
33293794	7	55	theme	release	924:930	arg1	pattern					932:938	the release pattern	920:938	the release pattern from the prepared formulations	920:969	RESULTS AND DISCUSSION It was evident that the release pattern from the prepared formulations was significantly influenced by the quantity of gum(s) in the tablet.
33293794	5	56	theme	granulation	703:713	arg1	approach					715:722	Wet granulation approach	699:722	Wet granulation approach	699:722	Wet granulation approach was used for the formulation of tablets.
33293794	11	57	dep	in	1450:1451	arg1	vitro					1453:1457	vitro	1453:1457	vitro	1453:1457	The optimized formula generated by the response surface methodology was evaluated both for in vitro and in vivo properties.
33293794	5	58	used	used	728:731	arg2	approach					715:722	Wet granulation approach	699:722	Wet granulation approach	699:722	Wet granulation approach was used for the formulation of tablets.
33293794	6	59	theme	investigations	816:829	arg1	studies					851:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies	765:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies	765:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies were carried out.
33293794	13	60	used	used	1870:1873	arg2	karaya					1824:1829	karaya	1824:1829	karaya	1824:1829	CONCLUSION The results indicated that karaya and locust bean gum can be effectively used to formulate sustained-release tablets.
33293794	13	60	used	used	1870:1873	arg2	gum					1847:1849	locust bean gum	1835:1849	locust bean gum	1835:1849	CONCLUSION The results indicated that karaya and locust bean gum can be effectively used to formulate sustained-release tablets.
33293794	13	61	theme	locust	1835:1840	arg1	gum					1847:1849	locust bean gum	1835:1849	locust bean gum	1835:1849	CONCLUSION The results indicated that karaya and locust bean gum can be effectively used to formulate sustained-release tablets.
33293794	10	62	theme	ANOVA	1244:1248	arg1	analysis					1250:1257	ANOVA analysis	1244:1257	ANOVA analysis	1244:1257	After ANOVA analysis, the significant factors were considered for constrained optimization to get the optimized formula.
33293794	9	63	from	prediction	1138:1147	arg1	levels					1208:1213	different levels	1198:1213	different levels	1198:1213	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	9	63	from	prediction	1138:1147	arg1	variables					1227:1235	response variables	1218:1235	response variables	1218:1235	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	8	64	theme	drug-polymer	1071:1082	arg1	compatibility					1084:1096	drug-polymer compatibility	1071:1096	drug-polymer compatibility	1071:1096	FT-IR and DSC results confirm drug-polymer compatibility.
33293794	13	65	theme	bean	1842:1845	arg1	gum					1847:1849	locust bean gum	1835:1849	locust bean gum	1835:1849	CONCLUSION The results indicated that karaya and locust bean gum can be effectively used to formulate sustained-release tablets.
33293794	1	66	theme	natural	185:191	arg1	gum					222:224	locust bean gum	210:224	locust bean gum	210:224	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	1	66	theme	natural	185:191	arg1	karaya					199:204	karaya	199:204	karaya	199:204	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	1	66	theme	natural	185:191	arg1	gums					193:196	natural gums	185:196	natural gums	185:196	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	12	67	from	studies	1572:1578	arg1	rabbits					1583:1589	rabbits	1583:1589	rabbits	1583:1589	The optimized formula and a sustained-release marketed product were subjected to in vivo studies in rabbits and the results of the t-test demonstrated insignificant variation in pharmacokinetic parameters among the two formulations, confirming that the prepared tablet showed sustained-release profile.
33293794	5	68	theme	tablets	756:762	arg1	formulation					741:751	the formulation	737:751	the formulation of tablets	737:762	Wet granulation approach was used for the formulation of tablets.
33293794	4	69	theme	diffusion	616:624	arg1	exponent					626:633	diffusion exponent	616:633	diffusion exponent (Y3)	616:638	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	69	theme	diffusion	616:624	arg1	Y3					636:637	Y3	636:637	Y3	636:637	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	12	70	dep	in	1564:1565	arg1	vivo					1567:1570	vivo	1567:1570	vivo	1567:1570	The optimized formula and a sustained-release marketed product were subjected to in vivo studies in rabbits and the results of the t-test demonstrated insignificant variation in pharmacokinetic parameters among the two formulations, confirming that the prepared tablet showed sustained-release profile.
33293794	12	71	theme	in	1564:1565	arg1	studies					1572:1578	in vivo studies	1564:1578	in vivo studies in rabbits	1564:1589	The optimized formula and a sustained-release marketed product were subjected to in vivo studies in rabbits and the results of the t-test demonstrated insignificant variation in pharmacokinetic parameters among the two formulations, confirming that the prepared tablet showed sustained-release profile.
33293794	0	72	theme	Response	60:67	arg1	Methodology					77:87	Response Surface Methodology	60:87	Response Surface Methodology	60:87	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	9	73	theme	Polynomial	1099:1108	arg1	equations					1110:1118	Polynomial equations	1099:1118	Polynomial equations	1099:1118	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	11	74	theme	optimized	1363:1371	arg1	formula					1373:1379	The optimized formula	1359:1379	The optimized formula generated by the response surface methodology	1359:1425	The optimized formula generated by the response surface methodology was evaluated both for in vitro and in vivo properties.
33293794	1	75	theme	diltiazem	306:314	arg1	tablets					295:301	sustained-release tablets	277:301	sustained-release tablets of diltiazem, a model drug	277:328	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	9	76	from	levels	1208:1213	arg1	prediction					1138:1147	the prediction	1134:1147	the prediction of quantitative impact of independent factors at different levels on response variables	1134:1235	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	9	76	from	levels	1208:1213	arg1	impact					1165:1170	quantitative impact	1152:1170	quantitative impact of independent factors at different levels on response variables	1152:1235	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	1	77	theme	present	135:141	arg1	work					143:146	The present work	131:146	The present work	131:146	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	0	78	theme	in	90:91	arg1	Evaluation					111:120	in vitro and in vivo Evaluation	90:120	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.	0:121	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	6	79	theme	SEM	832:834	arg1	studies					851:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies	765:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies	765:857	FT-IR, DSC, in vitro dissolution, swelling-erosion investigations, SEM, and stability studies were carried out.
33293794	0	80	from	Matrices	48:55	arg1	Modulation					0:9	Modulation	0:9	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.	0:121	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	0	80	from	Matrices	48:55	arg1	Release					19:25	Drug Release	14:25	Drug Release from Natural Polymer Matrices	14:55	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	10	81	theme	significant	1264:1274	arg1	factors					1276:1282	the significant factors	1260:1282	the significant factors	1260:1282	After ANOVA analysis, the significant factors were considered for constrained optimization to get the optimized formula.
33293794	4	82	dep	amount	533:538	arg1	Y4					694:695	Y4	694:695	Y4	694:695	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	0	83	dep	in	90:91	arg1	vitro					93:97	vitro	93:97	vitro	93:97	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	9	84	theme	quantitative	1152:1163	arg1	impact					1165:1170	quantitative impact	1152:1170	quantitative impact of independent factors at different levels on response variables	1152:1235	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	9	85	from	impact	1165:1170	arg1	variables					1227:1235	response variables	1218:1235	response variables	1218:1235	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	2	86	theme	Central	339:345	arg1	composite					354:362	Central design composite	339:362	Central design composite	339:362	METHODS Central design composite was adopted for the formulation and optimization of tablet formulations.
33293794	0	87	theme	Release	19:25	arg1	Modulation					0:9	Modulation	0:9	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.	0:121	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	12	88	theme	prepared	1736:1743	arg1	tablet					1745:1750	the prepared tablet	1732:1750	the prepared tablet	1732:1750	The optimized formula and a sustained-release marketed product were subjected to in vivo studies in rabbits and the results of the t-test demonstrated insignificant variation in pharmacokinetic parameters among the two formulations, confirming that the prepared tablet showed sustained-release profile.
33293794	10	89	theme	optimized	1340:1348	arg1	formula					1350:1356	the optimized formula	1336:1356	the optimized formula	1336:1356	After ANOVA analysis, the significant factors were considered for constrained optimization to get the optimized formula.
33293794	0	90	theme	Natural	32:38	arg1	Matrices					48:55	Natural Polymer Matrices	32:55	Natural Polymer Matrices	32:55	Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation.
33293794	9	91	theme	factors	1187:1193	arg1	impact					1165:1170	quantitative impact	1152:1170	quantitative impact of independent factors at different levels on response variables	1152:1235	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	12	92	theme	optimized	1487:1495	arg1	formula					1497:1503	The optimized formula	1483:1503	The optimized formula	1483:1503	The optimized formula and a sustained-release marketed product were subjected to in vivo studies in rabbits and the results of the t-test demonstrated insignificant variation in pharmacokinetic parameters among the two formulations, confirming that the prepared tablet showed sustained-release profile.
33293794	4	93	theme	dependent	499:507	arg1	factors					509:515	The dependent factors	495:515	The dependent factors chosen	495:522	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	93	theme	dependent	499:507	arg1	drug					543:546	drug	543:546	drug	543:546	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	93	theme	dependent	499:507	arg1	drug					585:588	drug	585:588	drug	585:588	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	93	theme	dependent	499:507	arg1	amount					533:538	the amount	529:538	the amount of drug released in 1st hour (Y1)	529:572	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	11	94	theme	in	1450:1451	arg1	properties					1471:1480	in vitro and in vivo properties	1450:1480	in vitro and in vivo properties	1450:1480	The optimized formula generated by the response surface methodology was evaluated both for in vitro and in vivo properties.
33293794	9	95	theme	different	1198:1206	arg1	levels					1208:1213	different levels	1198:1213	different levels	1198:1213	Polynomial equations were used for the prediction of quantitative impact of independent factors at different levels on response variables.
33293794	2	96	theme	formulations	423:434	arg1	optimization					400:411	optimization	400:411	optimization	400:411	METHODS Central design composite was adopted for the formulation and optimization of tablet formulations.
33293794	2	96	theme	formulations	423:434	arg1	formulation					384:394	formulation	384:394	formulation	384:394	METHODS Central design composite was adopted for the formulation and optimization of tablet formulations.
33293794	12	97	theme	sustained-release	1759:1775	arg1	profile					1777:1783	sustained-release profile	1759:1783	sustained-release profile	1759:1783	The optimized formula and a sustained-release marketed product were subjected to in vivo studies in rabbits and the results of the t-test demonstrated insignificant variation in pharmacokinetic parameters among the two formulations, confirming that the prepared tablet showed sustained-release profile.
33293794	1	98	theme	tablets	295:301	arg1	formulation					262:272	the formulation	258:272	the formulation of sustained-release tablets of diltiazem, a model drug	258:328	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	4	99	theme	total	666:670	arg1	%					690:690	T50%	687:690	T50%	687:690	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	4	99	theme	total	666:670	arg1	drug					672:675	the total drug	662:675	the total drug released (T50%)	662:691	The dependent factors chosen were the amount of drug released in 1st hour (Y1), amount of drug released after 12 h (Y2), diffusion exponent (Y3), and time for half of the total drug released (T50%) (Y4).
33293794	12	100	dep	marketed	1529:1536	arg1	sustained-release					1511:1527	sustained-release	1511:1527	sustained-release	1511:1527	The optimized formula and a sustained-release marketed product were subjected to in vivo studies in rabbits and the results of the t-test demonstrated insignificant variation in pharmacokinetic parameters among the two formulations, confirming that the prepared tablet showed sustained-release profile.
33293794	5	101	theme	Wet	699:701	arg1	approach					715:722	Wet granulation approach	699:722	Wet granulation approach	699:722	Wet granulation approach was used for the formulation of tablets.
33293794	12	102	theme	insignificant	1634:1646	arg1	variation					1648:1656	insignificant variation	1634:1656	insignificant variation in pharmacokinetic parameters among the two formulations	1634:1713	The optimized formula and a sustained-release marketed product were subjected to in vivo studies in rabbits and the results of the t-test demonstrated insignificant variation in pharmacokinetic parameters among the two formulations, confirming that the prepared tablet showed sustained-release profile.
33293794	1	103	theme	locust	210:215	arg1	gum					222:224	locust bean gum	210:224	locust bean gum	210:224	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
33293794	1	103	theme	locust	210:215	arg1	gums					193:196	natural gums	185:196	natural gums	185:196	PURPOSE The present work aimed at challenging the efficacy of natural gums, karaya and locust bean gum, as matrix-forming polymers for the formulation of sustained-release tablets of diltiazem, a model drug.
34813789	0	0	theme	chromium	93:100	arg1	adsorption					68:77	adsorption	68:77	adsorption of hexavalent chromium from aqueous solutions	68:123	Green method to synthesize magnetic zeolite/chitosan composites and adsorption of hexavalent chromium from aqueous solutions.
34813789	0	0	theme	chromium	93:100	arg1	chromium					93:100	hexavalent chromium	82:100	hexavalent chromium	82:100	Green method to synthesize magnetic zeolite/chitosan composites and adsorption of hexavalent chromium from aqueous solutions.
34813789	0	0	theme	chromium	93:100	arg1	composites					53:62	magnetic zeolite/chitosan composites	27:62	magnetic zeolite/chitosan composites	27:62	Green method to synthesize magnetic zeolite/chitosan composites and adsorption of hexavalent chromium from aqueous solutions.
34813789	1	1	with	method	238:243	arg1	Cr					258:259	Cr(VI) water pollution	258:279	Cr(VI) water pollution	258:279	This paper aims to synthesis a recyclable adsorbent from solid waste using a clean and environmentally friendly method to deal with Cr(VI) water pollution.
34813789	4	2	theme	cross-linked	571:582	arg1	ZFA/MCS					584:590	cross-linked ZFA/MCS	571:590	cross-linked ZFA/MCS	571:590	The results showed that cross-linked ZFA/MCS generally showed higher adsorption capacity than uncross-linked ones.
34813789	0	3	theme	hexavalent	82:91	arg1	chromium					93:100	hexavalent chromium	82:100	hexavalent chromium	82:100	Green method to synthesize magnetic zeolite/chitosan composites and adsorption of hexavalent chromium from aqueous solutions.
34813789	6	4	theme	monolayer	972:980	arg1	adsorption					948:957	the adsorption	944:957	the adsorption	944:957	The experimental values were followed Langmuir adsorption equations and pseudo-second-order kinetic model, indicating that the adsorption was probably monolayer coverage and chemical adsorption, respectively.
34813789	6	4	theme	monolayer	972:980	arg1	coverage					982:989	monolayer coverage	972:989	monolayer coverage	972:989	The experimental values were followed Langmuir adsorption equations and pseudo-second-order kinetic model, indicating that the adsorption was probably monolayer coverage and chemical adsorption, respectively.
34813789	5	5	theme	uncross-linked	666:679	arg1	ZFA/MCS					681:687	The uncross-linked ZFA/MCS	662:687	The uncross-linked ZFA/MCS	662:687	The uncross-linked ZFA/MCS and cross-linked ZFA/MCS showed a saturated adsorption capacity of 25.67 mg·g-1 and 28.47 mg·g-1 at pH = 3 and 30 °C, respectively.
34813789	6	6	theme	Langmuir	859:866	arg1	adsorption					868:877	Langmuir adsorption	859:877	Langmuir adsorption equations	859:887	The experimental values were followed Langmuir adsorption equations and pseudo-second-order kinetic model, indicating that the adsorption was probably monolayer coverage and chemical adsorption, respectively.
34813789	0	7	theme	aqueous	107:113	arg1	solutions					115:123	aqueous solutions	107:123	aqueous solutions	107:123	Green method to synthesize magnetic zeolite/chitosan composites and adsorption of hexavalent chromium from aqueous solutions.
34813789	5	8	theme	adsorption	733:742	arg1	capacity					744:751	a saturated adsorption capacity	721:751	a saturated adsorption capacity of 25.67 mg·g-1 and 28.47 mg·g-1	721:784	The uncross-linked ZFA/MCS and cross-linked ZFA/MCS showed a saturated adsorption capacity of 25.67 mg·g-1 and 28.47 mg·g-1 at pH = 3 and 30 °C, respectively.
34813789	5	9	theme	28.47 mg·g-1	773:784	arg1	capacity					744:751	a saturated adsorption capacity	721:751	a saturated adsorption capacity of 25.67 mg·g-1 and 28.47 mg·g-1	721:784	The uncross-linked ZFA/MCS and cross-linked ZFA/MCS showed a saturated adsorption capacity of 25.67 mg·g-1 and 28.47 mg·g-1 at pH = 3 and 30 °C, respectively.
34813789	3	10	theme	neutralization	427:440	arg1	method					442:447	the neutralization method	423:447	the neutralization method for Cr(VI) ions	423:463	The adsorption properties of ZFA/MCS, prepared by the neutralization method for Cr(VI) ions under different conditions especially cross-linking, were investigated in detail.
34813789	6	11	theme	experimental	825:836	arg1	values					838:843	The experimental values	821:843	The experimental values	821:843	The experimental values were followed Langmuir adsorption equations and pseudo-second-order kinetic model, indicating that the adsorption was probably monolayer coverage and chemical adsorption, respectively.
34813789	1	12	theme	solid	183:187	arg1	waste					189:193	solid waste	183:193	solid waste using a clean and environmentally friendly method to deal with Cr(VI) water pollution	183:279	This paper aims to synthesis a recyclable adsorbent from solid waste using a clean and environmentally friendly method to deal with Cr(VI) water pollution.
34813789	3	13	theme	adsorption	377:386	arg1	properties					388:397	The adsorption properties	373:397	The adsorption properties	373:397	The adsorption properties of ZFA/MCS, prepared by the neutralization method for Cr(VI) ions under different conditions especially cross-linking, were investigated in detail.
34813789	8	14	theme	excellent	1146:1154	arg1	recyclability					1156:1168	excellent recyclability	1146:1168	excellent recyclability	1146:1168	Therefore, the adsorbent with excellent recyclability and adsorbability was successfully fabricated via a green synthetic strategy.
34813789	0	15	theme	Green	0:4	arg1	method					6:11	Green method	0:11	Green method	0:11	Green method to synthesize magnetic zeolite/chitosan composites and adsorption of hexavalent chromium from aqueous solutions.
34813789	6	16	theme	adsorption	868:877	arg1	equations					879:887	Langmuir adsorption equations	859:887	Langmuir adsorption equations	859:887	The experimental values were followed Langmuir adsorption equations and pseudo-second-order kinetic model, indicating that the adsorption was probably monolayer coverage and chemical adsorption, respectively.
34813789	1	17	theme	water	265:269	arg1	pollution					271:279	water pollution	265:279	Cr(VI) water pollution	258:279	This paper aims to synthesis a recyclable adsorbent from solid waste using a clean and environmentally friendly method to deal with Cr(VI) water pollution.
34813789	5	18	theme	saturated	723:731	arg1	capacity					744:751	a saturated adsorption capacity	721:751	a saturated adsorption capacity of 25.67 mg·g-1 and 28.47 mg·g-1	721:784	The uncross-linked ZFA/MCS and cross-linked ZFA/MCS showed a saturated adsorption capacity of 25.67 mg·g-1 and 28.47 mg·g-1 at pH = 3 and 30 °C, respectively.
34813789	2	19	theme	zeolite/chitosan	291:306	arg1	ZFA/MCS					320:326	ZFA/MCS	320:326	ZFA/MCS	320:326	Magnetic zeolite/chitosan composites (ZFA/MCS) were prepared by the neutralization method.
34813789	2	19	theme	zeolite/chitosan	291:306	arg1	composites					308:317	Magnetic zeolite/chitosan composites	282:317	Magnetic zeolite/chitosan composites (ZFA/MCS)	282:327	Magnetic zeolite/chitosan composites (ZFA/MCS) were prepared by the neutralization method.
34813789	4	20	theme	uncross-linked	641:654	arg1	ones					656:659	uncross-linked ones	641:659	uncross-linked ones	641:659	The results showed that cross-linked ZFA/MCS generally showed higher adsorption capacity than uncross-linked ones.
34813789	5	21	link	uncross-linked	666:679	arg1	ZFA/MCS					681:687	The uncross-linked ZFA/MCS	662:687	The uncross-linked ZFA/MCS	662:687	The uncross-linked ZFA/MCS and cross-linked ZFA/MCS showed a saturated adsorption capacity of 25.67 mg·g-1 and 28.47 mg·g-1 at pH = 3 and 30 °C, respectively.
34813789	4	22	theme	higher	609:614	arg1	capacity					627:634	higher adsorption capacity	609:634	higher adsorption capacity	609:634	The results showed that cross-linked ZFA/MCS generally showed higher adsorption capacity than uncross-linked ones.
34813789	2	23	theme	Magnetic	282:289	arg1	ZFA/MCS					320:326	ZFA/MCS	320:326	ZFA/MCS	320:326	Magnetic zeolite/chitosan composites (ZFA/MCS) were prepared by the neutralization method.
34813789	2	23	theme	Magnetic	282:289	arg1	composites					308:317	Magnetic zeolite/chitosan composites	282:317	Magnetic zeolite/chitosan composites (ZFA/MCS)	282:327	Magnetic zeolite/chitosan composites (ZFA/MCS) were prepared by the neutralization method.
34813789	8	24	with	adsorbent	1131:1139	arg1	adsorbability					1174:1186	adsorbability	1174:1186	adsorbability	1174:1186	Therefore, the adsorbent with excellent recyclability and adsorbability was successfully fabricated via a green synthetic strategy.
34813789	8	24	with	adsorbent	1131:1139	arg1	recyclability					1156:1168	excellent recyclability	1146:1168	excellent recyclability	1146:1168	Therefore, the adsorbent with excellent recyclability and adsorbability was successfully fabricated via a green synthetic strategy.
34813789	1	25	theme	clean	203:207	arg1	method					238:243	a clean and environmentally friendly method	201:243	a clean and environmentally friendly method to deal with Cr(VI) water pollution	201:279	This paper aims to synthesis a recyclable adsorbent from solid waste using a clean and environmentally friendly method to deal with Cr(VI) water pollution.
34813789	0	26	theme	zeolite/chitosan	36:51	arg1	chromium					93:100	hexavalent chromium	82:100	hexavalent chromium	82:100	Green method to synthesize magnetic zeolite/chitosan composites and adsorption of hexavalent chromium from aqueous solutions.
34813789	0	26	theme	zeolite/chitosan	36:51	arg1	composites					53:62	magnetic zeolite/chitosan composites	27:62	magnetic zeolite/chitosan composites	27:62	Green method to synthesize magnetic zeolite/chitosan composites and adsorption of hexavalent chromium from aqueous solutions.
34813789	0	27	theme	magnetic	27:34	arg1	chromium					93:100	hexavalent chromium	82:100	hexavalent chromium	82:100	Green method to synthesize magnetic zeolite/chitosan composites and adsorption of hexavalent chromium from aqueous solutions.
34813789	0	27	theme	magnetic	27:34	arg1	composites					53:62	magnetic zeolite/chitosan composites	27:62	magnetic zeolite/chitosan composites	27:62	Green method to synthesize magnetic zeolite/chitosan composites and adsorption of hexavalent chromium from aqueous solutions.
34813789	1	28	theme	environmentally	213:227	arg1	method					238:243	a clean and environmentally friendly method	201:243	a clean and environmentally friendly method to deal with Cr(VI) water pollution	201:279	This paper aims to synthesis a recyclable adsorbent from solid waste using a clean and environmentally friendly method to deal with Cr(VI) water pollution.
34813789	5	29	theme	25.67 mg·g-1	756:767	arg1	capacity					744:751	a saturated adsorption capacity	721:751	a saturated adsorption capacity of 25.67 mg·g-1 and 28.47 mg·g-1	721:784	The uncross-linked ZFA/MCS and cross-linked ZFA/MCS showed a saturated adsorption capacity of 25.67 mg·g-1 and 28.47 mg·g-1 at pH = 3 and 30 °C, respectively.
34813789	5	30	theme	cross-linked	693:704	arg1	ZFA/MCS					706:712	cross-linked ZFA/MCS	693:712	cross-linked ZFA/MCS	693:712	The uncross-linked ZFA/MCS and cross-linked ZFA/MCS showed a saturated adsorption capacity of 25.67 mg·g-1 and 28.47 mg·g-1 at pH = 3 and 30 °C, respectively.
34813789	6	31	theme	kinetic	913:919	arg1	model					921:925	pseudo-second-order kinetic model	893:925	pseudo-second-order kinetic model	893:925	The experimental values were followed Langmuir adsorption equations and pseudo-second-order kinetic model, indicating that the adsorption was probably monolayer coverage and chemical adsorption, respectively.
34813789	3	32	theme	ZFA/MCS	402:408	arg1	properties					388:397	The adsorption properties	373:397	The adsorption properties	373:397	The adsorption properties of ZFA/MCS, prepared by the neutralization method for Cr(VI) ions under different conditions especially cross-linking, were investigated in detail.
34813789	6	33	theme	pseudo-second-order	893:911	arg1	model					921:925	pseudo-second-order kinetic model	893:925	pseudo-second-order kinetic model	893:925	The experimental values were followed Langmuir adsorption equations and pseudo-second-order kinetic model, indicating that the adsorption was probably monolayer coverage and chemical adsorption, respectively.
34813789	3	34	theme	different	471:479	arg1	conditions					481:490	different conditions	471:490	different conditions especially cross-linking	471:515	The adsorption properties of ZFA/MCS, prepared by the neutralization method for Cr(VI) ions under different conditions especially cross-linking, were investigated in detail.
34813789	6	35	theme	chemical	995:1002	arg1	adsorption					1004:1013	chemical adsorption	995:1013	chemical adsorption	995:1013	The experimental values were followed Langmuir adsorption equations and pseudo-second-order kinetic model, indicating that the adsorption was probably monolayer coverage and chemical adsorption, respectively.
34813789	0	36	from	solutions	115:123	arg1	adsorption					68:77	adsorption	68:77	adsorption of hexavalent chromium from aqueous solutions	68:123	Green method to synthesize magnetic zeolite/chitosan composites and adsorption of hexavalent chromium from aqueous solutions.
34813789	0	36	from	solutions	115:123	arg1	chromium					93:100	hexavalent chromium	82:100	hexavalent chromium	82:100	Green method to synthesize magnetic zeolite/chitosan composites and adsorption of hexavalent chromium from aqueous solutions.
34813789	0	36	from	solutions	115:123	arg1	composites					53:62	magnetic zeolite/chitosan composites	27:62	magnetic zeolite/chitosan composites	27:62	Green method to synthesize magnetic zeolite/chitosan composites and adsorption of hexavalent chromium from aqueous solutions.
34813789	5	37	link	cross-linked	693:704	arg1	ZFA/MCS					706:712	cross-linked ZFA/MCS	693:712	cross-linked ZFA/MCS	693:712	The uncross-linked ZFA/MCS and cross-linked ZFA/MCS showed a saturated adsorption capacity of 25.67 mg·g-1 and 28.47 mg·g-1 at pH = 3 and 30 °C, respectively.
34813789	1	38	theme	friendly	229:236	arg1	method					238:243	a clean and environmentally friendly method	201:243	a clean and environmentally friendly method to deal with Cr(VI) water pollution	201:279	This paper aims to synthesis a recyclable adsorbent from solid waste using a clean and environmentally friendly method to deal with Cr(VI) water pollution.
34813789	4	39	link	cross-linked	571:582	arg1	ZFA/MCS					584:590	cross-linked ZFA/MCS	571:590	cross-linked ZFA/MCS	571:590	The results showed that cross-linked ZFA/MCS generally showed higher adsorption capacity than uncross-linked ones.
34813789	3	40	dep	Cr	453:454	arg1	ions					460:463	ions	460:463	Cr(VI) ions	453:463	The adsorption properties of ZFA/MCS, prepared by the neutralization method for Cr(VI) ions under different conditions especially cross-linking, were investigated in detail.
34813789	3	40	dep	Cr	453:454	arg1	VI					456:457	VI	456:457	VI	456:457	The adsorption properties of ZFA/MCS, prepared by the neutralization method for Cr(VI) ions under different conditions especially cross-linking, were investigated in detail.
34813789	1	41	from	waste	189:193	arg1	synthesis					145:153	synthesis	145:153	synthesis	145:153	This paper aims to synthesis a recyclable adsorbent from solid waste using a clean and environmentally friendly method to deal with Cr(VI) water pollution.
34813789	8	42	theme	synthetic	1228:1236	arg1	strategy					1238:1245	a green synthetic strategy	1220:1245	a green synthetic strategy	1220:1245	Therefore, the adsorbent with excellent recyclability and adsorbability was successfully fabricated via a green synthetic strategy.
34813789	1	43	dep	Cr	258:259	arg1	pollution					271:279	water pollution	265:279	Cr(VI) water pollution	258:279	This paper aims to synthesis a recyclable adsorbent from solid waste using a clean and environmentally friendly method to deal with Cr(VI) water pollution.
34813789	1	43	dep	Cr	258:259	arg1	VI					261:262	VI	261:262	VI	261:262	This paper aims to synthesis a recyclable adsorbent from solid waste using a clean and environmentally friendly method to deal with Cr(VI) water pollution.
34813789	4	44	link	uncross-linked	641:654	arg1	ones					656:659	uncross-linked ones	641:659	uncross-linked ones	641:659	The results showed that cross-linked ZFA/MCS generally showed higher adsorption capacity than uncross-linked ones.
34813789	3	45	theme	cross-linking	503:515	arg1	conditions					481:490	different conditions	471:490	different conditions especially cross-linking	471:515	The adsorption properties of ZFA/MCS, prepared by the neutralization method for Cr(VI) ions under different conditions especially cross-linking, were investigated in detail.
34813789	8	46	theme	green	1222:1226	arg1	strategy					1238:1245	a green synthetic strategy	1220:1245	a green synthetic strategy	1220:1245	Therefore, the adsorbent with excellent recyclability and adsorbability was successfully fabricated via a green synthetic strategy.
34813789	7	47	theme	temperature	1044:1054	arg1	effect					1034:1039	The effect	1030:1039	The effect of temperature	1030:1054	The effect of temperature proved that the adsorption was spontaneous and endothermic.
34813789	2	48	theme	neutralization	350:363	arg1	method					365:370	the neutralization method	346:370	the neutralization method	346:370	Magnetic zeolite/chitosan composites (ZFA/MCS) were prepared by the neutralization method.
34813789	4	49	theme	adsorption	616:625	arg1	capacity					627:634	higher adsorption capacity	609:634	higher adsorption capacity	609:634	The results showed that cross-linked ZFA/MCS generally showed higher adsorption capacity than uncross-linked ones.
32201365	9	0	theme	vast	1804:1807	arg1	excess					1809:1814	a vast excess	1802:1814	a vast excess of CS	1802:1820	Furthermore, as chondrocytes produce 100-fold more CS than HS the increased CS levels point to an active, precursor-independent mechanism that senses the quality of HS in a vast excess of CS.
32201365	3	1	theme	HS	673:674	arg1	levels					663:668	either reduced levels	648:668	either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice)	648:736	To understand this difference, we have investigated the glycosaminoglycan (GAG) composition in two mouse lines that produce either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice).
32201365	6	2	theme	wild	1230:1233	arg1	littermates					1240:1250	wild type littermates	1230:1250	wild type littermates	1230:1250	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	4	3	theme	mouse	851:855	arg1	lines					857:861	both mouse lines	846:861	both mouse lines	846:861	Analysis by RPIP-HPLC revealed an increased level of sulfated disaccarides not affected by the mutation in both mouse lines indicating that chondrocytes attempt to restore a critical level of sulfation.
32201365	3	4	theme	HS	696:697	arg1	levels					663:668	either reduced levels	648:668	either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice)	648:736	To understand this difference, we have investigated the glycosaminoglycan (GAG) composition in two mouse lines that produce either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice).
32201365	9	5	dep	active	1729:1734	arg1	precursor-independent					1737:1757	precursor-independent	1737:1757	precursor-independent	1737:1757	Furthermore, as chondrocytes produce 100-fold more CS than HS the increased CS levels point to an active, precursor-independent mechanism that senses the quality of HS in a vast excess of CS.
32201365	1	6	theme	endochondral	263:274	arg1	bones					276:280	endochondral bones	263:280	endochondral bones	263:280	Heparan sulfate (HS) regulates the activity of many signaling molecules critical for the development of endochondral bones.
32201365	7	7	theme	produced	1428:1435	arg1	CS					1437:1438	the additionally produced CS	1411:1438	the additionally produced CS	1411:1438	Expression analysis revealed an upregulation of aggrecan, which likely carries most of the additionally produced CS.
32201365	11	8	theme	factor	2085:2090	arg1	signaling					2092:2100	growth factor signaling	2078:2100	growth factor signaling in chondrocytes in distinct manners	2078:2136	In addition, Erk phosphorylation is increased independent of Fgf18 treatment indicating that both, HS and CS, affect growth factor signaling in chondrocytes in distinct manners.
32201365	7	9	theme	aggrecan	1372:1379	arg1	upregulation					1356:1367	an upregulation	1353:1367	an upregulation	1353:1367	Expression analysis revealed an upregulation of aggrecan, which likely carries most of the additionally produced CS.
32201365	11	10	from	chondrocytes	2105:2116	arg1	manners					2130:2136	distinct manners	2121:2136	distinct manners	2121:2136	In addition, Erk phosphorylation is increased independent of Fgf18 treatment indicating that both, HS and CS, affect growth factor signaling in chondrocytes in distinct manners.
32201365	3	11	theme	Hs2st1-/-	722:730	arg1	2-O-sulfation					707:719	2-O-sulfation	707:719	2-O-sulfation (Hs2st1-/- mice)	707:736	To understand this difference, we have investigated the glycosaminoglycan (GAG) composition in two mouse lines that produce either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice).
32201365	3	11	theme	Hs2st1-/-	722:730	arg1	mice					732:735	Hs2st1-/- mice	722:735	Hs2st1-/- mice	722:735	To understand this difference, we have investigated the glycosaminoglycan (GAG) composition in two mouse lines that produce either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice).
32201365	6	12	theme	CS	1129:1130	arg1	chains					1132:1137	more but shorter CS chains	1112:1137	more but shorter CS chains	1112:1137	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	10	13	theme	surface	1865:1871	arg1	CS					1873:1874	cell surface CS	1860:1874	cell surface CS	1860:1874	Interestingly, reducing the level of cell surface CS by chondroitinase treatment leads to reduced Bmp2 induced Smad1/5/9 phosphorylation.
32201365	0	14	theme	increased	118:126	arg1	levels					128:133	increased levels	118:133	increased levels of chondroitin sulfate	118:156	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
32201365	1	15	theme	many	206:209	arg1	molecules					221:229	many signaling molecules	206:229	many signaling molecules critical for the development of endochondral bones	206:280	Heparan sulfate (HS) regulates the activity of many signaling molecules critical for the development of endochondral bones.
32201365	7	16	theme	Expression	1324:1333	arg1	analysis					1335:1342	Expression analysis	1324:1342	Expression analysis	1324:1342	Expression analysis revealed an upregulation of aggrecan, which likely carries most of the additionally produced CS.
32201365	0	17	theme	sulfate	150:156	arg1	changes					77:83	distinct changes	68:83	distinct changes of heparan sulfate structure	68:112	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
32201365	0	17	theme	sulfate	150:156	arg1	levels					128:133	increased levels	118:133	increased levels of chondroitin sulfate	118:156	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
32201365	5	18	theme	elevated	1007:1014	arg1	levels					1016:1021	significantly elevated levels	993:1021	significantly elevated levels of CS	993:1027	In addition, in both mutant lines we also detected significantly elevated levels of CS.
32201365	3	19	theme	glycosaminoglycan	580:596	arg1	composition					604:614	the glycosaminoglycan (GAG) composition	576:614	the glycosaminoglycan (GAG) composition in two mouse lines that produce either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice)	576:736	To understand this difference, we have investigated the glycosaminoglycan (GAG) composition in two mouse lines that produce either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice).
32201365	11	20	theme	treatment	2028:2036	arg1	independent					2007:2017	independent	2007:2017	independent	2007:2017	In addition, Erk phosphorylation is increased independent of Fgf18 treatment indicating that both, HS and CS, affect growth factor signaling in chondrocytes in distinct manners.
32201365	2	21	from	signaling	497:505	arg1	chondrocytes					510:521	chondrocytes	510:521	chondrocytes	510:521	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	6	22	theme	Hs2st1-/-	1173:1181	arg1	mutants					1189:1195	by (Hs2st1-/- mice) mutants	1169:1195	by (Hs2st1-/- mice) mutants	1169:1195	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	6	22	theme	Hs2st1-/-	1173:1181	arg1	mice					1183:1186	Hs2st1-/- mice	1173:1186	Hs2st1-/- mice	1173:1186	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	10	23	theme	Smad1/5/9	1934:1942	arg1	phosphorylation					1944:1958	reduced Bmp2 induced Smad1/5/9 phosphorylation	1913:1958	reduced Bmp2 induced Smad1/5/9 phosphorylation	1913:1958	Interestingly, reducing the level of cell surface CS by chondroitinase treatment leads to reduced Bmp2 induced Smad1/5/9 phosphorylation.
32201365	2	24	theme	growth-factor	483:495	arg1	signaling					497:505	growth-factor signaling	483:505	growth-factor signaling in chondrocytes	483:521	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	2	25	from	chondrocytes	510:521	arg1	dependency					469:478	a reduced HS dependency	456:478	a reduced HS dependency of growth-factor signaling in chondrocytes	456:521	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	11	26	theme	distinct	2121:2128	arg1	manners					2130:2136	distinct manners	2121:2136	distinct manners	2121:2136	In addition, Erk phosphorylation is increased independent of Fgf18 treatment indicating that both, HS and CS, affect growth factor signaling in chondrocytes in distinct manners.
32201365	9	27	theme	CS	1707:1708	arg1	levels					1710:1715	the increased CS levels	1693:1715	100-fold more CS than HS the increased CS levels	1668:1715	Furthermore, as chondrocytes produce 100-fold more CS than HS the increased CS levels point to an active, precursor-independent mechanism that senses the quality of HS in a vast excess of CS.
32201365	0	28	theme	heparan	88:94	arg1	sulfate					96:102	heparan sulfate	88:102	heparan sulfate structure	88:112	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
32201365	4	29	theme	sulfation	931:939	arg1	level					922:926	a critical level	911:926	a critical level of sulfation	911:939	Analysis by RPIP-HPLC revealed an increased level of sulfated disaccarides not affected by the mutation in both mouse lines indicating that chondrocytes attempt to restore a critical level of sulfation.
32201365	8	30	from	levels	1596:1601	arg1	tissues					1622:1628	mammalian tissues	1612:1628	mammalian tissues	1612:1628	Together the results of this study demonstrate for the first time that not only a reduced HS synthesis but also an altered HS structure leads to increased levels of CS in mammalian tissues.
32201365	3	31	from	composition	604:614	arg1	lines					629:633	two mouse lines	619:633	two mouse lines that produce either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice)	619:736	To understand this difference, we have investigated the glycosaminoglycan (GAG) composition in two mouse lines that produce either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice).
32201365	0	32	theme	structure	104:112	arg1	changes					77:83	distinct changes	68:83	distinct changes of heparan sulfate structure	68:112	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
32201365	0	32	theme	structure	104:112	arg1	levels					128:133	increased levels	118:133	increased levels of chondroitin sulfate	118:156	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
32201365	6	33	theme	exclusion	1035:1043	arg1	chromatography					1045:1058	Size exclusion chromatography	1030:1058	Size exclusion chromatography	1030:1058	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	11	34	theme	growth	2078:2083	arg1	factor					2085:2090	growth factor	2078:2090	growth factor signaling in chondrocytes in distinct manners	2078:2136	In addition, Erk phosphorylation is increased independent of Fgf18 treatment indicating that both, HS and CS, affect growth factor signaling in chondrocytes in distinct manners.
32201365	1	35	theme	bones	276:280	arg1	development					248:258	the development	244:258	the development of endochondral bones	244:280	Heparan sulfate (HS) regulates the activity of many signaling molecules critical for the development of endochondral bones.
32201365	2	36	theme	reduced	458:464	arg1	dependency					469:478	a reduced HS dependency	456:478	a reduced HS dependency of growth-factor signaling in chondrocytes	456:521	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	0	37	theme	altered	27:33	arg1	composition					51:61	an altered heparan sulfate composition	24:61	an altered heparan sulfate composition	24:61	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
32201365	4	38	theme	disaccarides	801:812	arg1	level					783:787	an increased level	770:787	an increased level of sulfated disaccarides not affected by the mutation in both mouse lines	770:861	Analysis by RPIP-HPLC revealed an increased level of sulfated disaccarides not affected by the mutation in both mouse lines indicating that chondrocytes attempt to restore a critical level of sulfation.
32201365	0	39	theme	sulfate	43:49	arg1	composition					51:61	an altered heparan sulfate composition	24:61	an altered heparan sulfate composition	24:61	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
32201365	6	40	theme	more	1112:1115	arg1	chains					1132:1137	more but shorter CS chains	1112:1137	more but shorter CS chains	1112:1137	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	8	41	theme	HS	1531:1532	arg1	synthesis					1534:1542	a reduced HS synthesis	1521:1542	not only a reduced HS synthesis but also an altered HS structure	1512:1575	Together the results of this study demonstrate for the first time that not only a reduced HS synthesis but also an altered HS structure leads to increased levels of CS in mammalian tissues.
32201365	2	42	theme	altered	316:322	arg1	metabolism					327:336	a genetically altered HS metabolism	302:336	a genetically altered HS metabolism	302:336	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	8	43	theme	increased	1586:1594	arg1	levels					1596:1601	increased levels	1586:1601	increased levels of CS in mammalian tissues	1586:1628	Together the results of this study demonstrate for the first time that not only a reduced HS synthesis but also an altered HS structure leads to increased levels of CS in mammalian tissues.
32201365	1	44	theme	signaling	211:219	arg1	molecules					221:229	many signaling molecules	206:229	many signaling molecules critical for the development of endochondral bones	206:280	Heparan sulfate (HS) regulates the activity of many signaling molecules critical for the development of endochondral bones.
32201365	9	45	theme	HS	1796:1797	arg1	quality					1785:1791	the quality	1781:1791	the quality of HS	1781:1797	Furthermore, as chondrocytes produce 100-fold more CS than HS the increased CS levels point to an active, precursor-independent mechanism that senses the quality of HS in a vast excess of CS.
32201365	3	46	theme	reduced	655:661	arg1	levels					663:668	either reduced levels	648:668	either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice)	648:736	To understand this difference, we have investigated the glycosaminoglycan (GAG) composition in two mouse lines that produce either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice).
32201365	4	47	theme	increased	773:781	arg1	level					783:787	an increased level	770:787	an increased level of sulfated disaccarides not affected by the mutation in both mouse lines	770:861	Analysis by RPIP-HPLC revealed an increased level of sulfated disaccarides not affected by the mutation in both mouse lines indicating that chondrocytes attempt to restore a critical level of sulfation.
32201365	2	48	theme	mild	359:362	arg1	phenotype					373:381	a relatively mild skeletal phenotype	346:381	a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes	346:521	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	1	49	theme	critical	231:238	arg1	molecules					221:229	many signaling molecules	206:229	many signaling molecules critical for the development of endochondral bones	206:280	Heparan sulfate (HS) regulates the activity of many signaling molecules critical for the development of endochondral bones.
32201365	6	50	theme	type	1235:1238	arg1	littermates					1240:1250	wild type littermates	1230:1250	wild type littermates	1230:1250	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	8	51	theme	HS	1564:1565	arg1	structure					1567:1575	an altered HS structure	1553:1575	not only a reduced HS synthesis but also an altered HS structure	1512:1575	Together the results of this study demonstrate for the first time that not only a reduced HS synthesis but also an altered HS structure leads to increased levels of CS in mammalian tissues.
32201365	6	52	theme	CS	1150:1151	arg1	chains					1153:1158	the CS chains	1146:1158	the CS chains produced by (Hs2st1-/- mice) mutants	1146:1195	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	9	53	theme	CS	1819:1820	arg1	excess					1809:1814	a vast excess	1802:1814	a vast excess of CS	1802:1820	Furthermore, as chondrocytes produce 100-fold more CS than HS the increased CS levels point to an active, precursor-independent mechanism that senses the quality of HS in a vast excess of CS.
32201365	9	54	theme	increased	1697:1705	arg1	levels					1710:1715	the increased CS levels	1693:1715	100-fold more CS than HS the increased CS levels	1668:1715	Furthermore, as chondrocytes produce 100-fold more CS than HS the increased CS levels point to an active, precursor-independent mechanism that senses the quality of HS in a vast excess of CS.
32201365	6	55	theme	similar	1204:1210	arg1	length					1212:1217	similar length	1204:1217	similar length to that of wild type littermates	1204:1250	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	10	56	theme	CS	1873:1874	arg1	level					1851:1855	the level	1847:1855	the level of cell surface CS	1847:1874	Interestingly, reducing the level of cell surface CS by chondroitinase treatment leads to reduced Bmp2 induced Smad1/5/9 phosphorylation.
32201365	2	57	from	dependency	469:478	arg1	chondrocytes					510:521	chondrocytes	510:521	chondrocytes	510:521	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	6	58	theme	shorter	1121:1127	arg1	chains					1132:1137	more but shorter CS chains	1112:1137	more but shorter CS chains	1112:1137	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	10	59	theme	cell	1860:1863	arg1	CS					1873:1874	cell surface CS	1860:1874	cell surface CS	1860:1874	Interestingly, reducing the level of cell surface CS by chondroitinase treatment leads to reduced Bmp2 induced Smad1/5/9 phosphorylation.
32201365	0	60	theme	chondroitin	138:148	arg1	sulfate					150:156	chondroitin sulfate	138:156	chondroitin sulfate	138:156	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
32201365	11	61	theme	Erk	1974:1976	arg1	phosphorylation					1978:1992	Erk phosphorylation	1974:1992	Erk phosphorylation	1974:1992	In addition, Erk phosphorylation is increased independent of Fgf18 treatment indicating that both, HS and CS, affect growth factor signaling in chondrocytes in distinct manners.
32201365	11	62	theme	Fgf18	2022:2026	arg1	treatment					2028:2036	Fgf18 treatment	2022:2036	Fgf18 treatment indicating that both, HS and CS, affect growth factor signaling in chondrocytes in distinct manners	2022:2136	In addition, Erk phosphorylation is increased independent of Fgf18 treatment indicating that both, HS and CS, affect growth factor signaling in chondrocytes in distinct manners.
32201365	10	63	theme	chondroitinase	1879:1892	arg1	treatment					1894:1902	chondroitinase treatment	1879:1902	chondroitinase treatment	1879:1902	Interestingly, reducing the level of cell surface CS by chondroitinase treatment leads to reduced Bmp2 induced Smad1/5/9 phosphorylation.
32201365	4	64	from	level	783:787	arg1	lines					857:861	both mouse lines	846:861	both mouse lines	846:861	Analysis by RPIP-HPLC revealed an increased level of sulfated disaccarides not affected by the mutation in both mouse lines indicating that chondrocytes attempt to restore a critical level of sulfation.
32201365	9	65	theme	CS	1682:1683	arg1	levels					1710:1715	the increased CS levels	1693:1715	100-fold more CS than HS the increased CS levels	1668:1715	Furthermore, as chondrocytes produce 100-fold more CS than HS the increased CS levels point to an active, precursor-independent mechanism that senses the quality of HS in a vast excess of CS.
32201365	10	66	theme	induced	1926:1932	arg1	phosphorylation					1944:1958	reduced Bmp2 induced Smad1/5/9 phosphorylation	1913:1958	reduced Bmp2 induced Smad1/5/9 phosphorylation	1913:1958	Interestingly, reducing the level of cell surface CS by chondroitinase treatment leads to reduced Bmp2 induced Smad1/5/9 phosphorylation.
32201365	0	67	theme	distinct	68:75	arg1	changes					77:83	distinct changes	68:83	distinct changes of heparan sulfate structure	68:112	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
32201365	5	68	theme	CS	1026:1027	arg1	levels					1016:1021	significantly elevated levels	993:1021	significantly elevated levels of CS	993:1027	In addition, in both mutant lines we also detected significantly elevated levels of CS.
32201365	10	69	theme	reduced	1913:1919	arg1	phosphorylation					1944:1958	reduced Bmp2 induced Smad1/5/9 phosphorylation	1913:1958	reduced Bmp2 induced Smad1/5/9 phosphorylation	1913:1958	Interestingly, reducing the level of cell surface CS by chondroitinase treatment leads to reduced Bmp2 induced Smad1/5/9 phosphorylation.
32201365	1	70	theme	Heparan	159:165	arg1	HS					176:177	HS	176:177	HS	176:177	Heparan sulfate (HS) regulates the activity of many signaling molecules critical for the development of endochondral bones.
32201365	1	70	theme	Heparan	159:165	arg1	sulfate					167:173	Heparan sulfate	159:173	Heparan sulfate (HS)	159:178	Heparan sulfate (HS) regulates the activity of many signaling molecules critical for the development of endochondral bones.
32201365	2	71	with	mice	292:295	arg1	metabolism					327:336	a genetically altered HS metabolism	302:336	a genetically altered HS metabolism	302:336	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	2	72	theme	HS	466:467	arg1	dependency					469:478	a reduced HS dependency	456:478	a reduced HS dependency of growth-factor signaling in chondrocytes	456:521	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	8	73	theme	study	1470:1474	arg1	results					1454:1460	the results	1450:1460	the results of this study	1450:1474	Together the results of this study demonstrate for the first time that not only a reduced HS synthesis but also an altered HS structure leads to increased levels of CS in mammalian tissues.
32201365	2	74	located	observed	407:414	arg2	defects					399:405	the defects	395:405	the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes	395:521	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	2	74	located	observed	407:414	arg1	organs					437:442	organs	437:442	organs	437:442	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	2	74	located	observed	407:414	arg1	tissues					425:431	other tissues	419:431	other tissues	419:431	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	0	75	theme	sulfate	96:102	arg1	structure					104:112	heparan sulfate structure	88:112	heparan sulfate structure	88:112	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
32201365	4	76	theme	critical	913:920	arg1	level					922:926	a critical level	911:926	a critical level of sulfation	911:939	Analysis by RPIP-HPLC revealed an increased level of sulfated disaccarides not affected by the mutation in both mouse lines indicating that chondrocytes attempt to restore a critical level of sulfation.
32201365	6	77	theme	CS	1313:1314	arg1	chains					1316:1321	longer CS chains	1306:1321	longer CS chains	1306:1321	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	2	78	theme	signaling	497:505	arg1	dependency					469:478	a reduced HS dependency	456:478	a reduced HS dependency of growth-factor signaling in chondrocytes	456:521	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	8	79	theme	first	1496:1500	arg1	time					1502:1505	the first time	1492:1505	the first time	1492:1505	Together the results of this study demonstrate for the first time that not only a reduced HS synthesis but also an altered HS structure leads to increased levels of CS in mammalian tissues.
32201365	6	80	theme	Size	1030:1033	arg1	chromatography					1045:1058	Size exclusion chromatography	1030:1058	Size exclusion chromatography	1030:1058	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	9	81	theme	active	1729:1734	arg1	mechanism					1759:1767	an active, precursor-independent mechanism	1726:1767	an active, precursor-independent mechanism that senses the quality of HS in a vast excess of CS	1726:1820	Furthermore, as chondrocytes produce 100-fold more CS than HS the increased CS levels point to an active, precursor-independent mechanism that senses the quality of HS in a vast excess of CS.
32201365	2	82	theme	skeletal	364:371	arg1	phenotype					373:381	a relatively mild skeletal phenotype	346:381	a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes	346:521	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	2	83	theme	other	419:423	arg1	tissues					425:431	other tissues	419:431	other tissues	419:431	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	0	84	theme	heparan	35:41	arg1	sulfate					43:49	heparan sulfate	35:49	an altered heparan sulfate composition	24:61	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
32201365	8	85	theme	reduced	1523:1529	arg1	synthesis					1534:1542	a reduced HS synthesis	1521:1542	not only a reduced HS synthesis but also an altered HS structure	1512:1575	Together the results of this study demonstrate for the first time that not only a reduced HS synthesis but also an altered HS structure leads to increased levels of CS in mammalian tissues.
32201365	3	86	theme	mouse	623:627	arg1	lines					629:633	two mouse lines	619:633	two mouse lines that produce either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice)	619:736	To understand this difference, we have investigated the glycosaminoglycan (GAG) composition in two mouse lines that produce either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice).
32201365	6	87	theme	longer	1306:1311	arg1	chains					1316:1321	longer CS chains	1306:1321	longer CS chains	1306:1321	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	11	88	from	signaling	2092:2100	arg1	chondrocytes					2105:2116	chondrocytes	2105:2116	chondrocytes in distinct manners	2105:2136	In addition, Erk phosphorylation is increased independent of Fgf18 treatment indicating that both, HS and CS, affect growth factor signaling in chondrocytes in distinct manners.
32201365	4	89	theme	sulfated	792:799	arg1	disaccarides					801:812	sulfated disaccarides	792:812	sulfated disaccarides not affected by the mutation	792:841	Analysis by RPIP-HPLC revealed an increased level of sulfated disaccarides not affected by the mutation in both mouse lines indicating that chondrocytes attempt to restore a critical level of sulfation.
32201365	2	90	theme	HS	324:325	arg1	metabolism					327:336	a genetically altered HS metabolism	302:336	a genetically altered HS metabolism	302:336	Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes.
32201365	7	91	contain	carries	1395:1401	arg2	most					1403:1406	most	1403:1406	most	1403:1406	Expression analysis revealed an upregulation of aggrecan, which likely carries most of the additionally produced CS.
32201365	7	91	contain	carries	1395:1401	arg1	upregulation					1356:1367	an upregulation	1353:1367	an upregulation	1353:1367	Expression analysis revealed an upregulation of aggrecan, which likely carries most of the additionally produced CS.
32201365	7	91	contain	carries	1395:1401	arg2	CS					1437:1438	the additionally produced CS	1411:1438	the additionally produced CS	1411:1438	Expression analysis revealed an upregulation of aggrecan, which likely carries most of the additionally produced CS.
32201365	8	92	theme	CS	1606:1607	arg1	levels					1596:1601	increased levels	1586:1601	increased levels of CS in mammalian tissues	1586:1628	Together the results of this study demonstrate for the first time that not only a reduced HS synthesis but also an altered HS structure leads to increased levels of CS in mammalian tissues.
32201365	1	93	theme	molecules	221:229	arg1	activity					194:201	the activity	190:201	the activity of many signaling molecules critical for the development of endochondral bones	190:280	Heparan sulfate (HS) regulates the activity of many signaling molecules critical for the development of endochondral bones.
32201365	5	94	theme	mutant	963:968	arg1	lines					970:974	both mutant lines	958:974	both mutant lines	958:974	In addition, in both mutant lines we also detected significantly elevated levels of CS.
32201365	6	95	theme	Ext1gt/gt	1086:1094	arg1	mutants					1096:1102	Ext1gt/gt mutants	1086:1102	Ext1gt/gt mutants	1086:1102	Size exclusion chromatography further demonstrated that Ext1gt/gt mutants produce more but shorter CS chains, while the CS chains produced by (Hs2st1-/- mice) mutants are of similar length to that of wild type littermates indicating that chondrocytes produce more rather than longer CS chains.
32201365	8	96	theme	altered	1556:1562	arg1	structure					1567:1575	an altered HS structure	1553:1575	not only a reduced HS synthesis but also an altered HS structure	1512:1575	Together the results of this study demonstrate for the first time that not only a reduced HS synthesis but also an altered HS structure leads to increased levels of CS in mammalian tissues.
32201365	3	97	theme	Ext1gt/gt	677:685	arg1	HS					673:674	HS	673:674	HS (Ext1gt/gt mice)	673:691	To understand this difference, we have investigated the glycosaminoglycan (GAG) composition in two mouse lines that produce either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice).
32201365	3	97	theme	Ext1gt/gt	677:685	arg1	mice					687:690	Ext1gt/gt mice	677:690	Ext1gt/gt mice	677:690	To understand this difference, we have investigated the glycosaminoglycan (GAG) composition in two mouse lines that produce either reduced levels of HS (Ext1gt/gt mice) or HS lacking 2-O-sulfation (Hs2st1-/- mice).
32201365	8	98	theme	mammalian	1612:1620	arg1	tissues					1622:1628	mammalian tissues	1612:1628	mammalian tissues	1612:1628	Together the results of this study demonstrate for the first time that not only a reduced HS synthesis but also an altered HS structure leads to increased levels of CS in mammalian tissues.
31801176	8	0	theme	Fecal	1049:1053	arg1	concentration					1064:1076	Fecal butyrate concentration	1049:1076	Fecal butyrate concentration	1049:1076	Fecal butyrate concentration is higher in the NW-group at 9 months of age.
31801176	9	1	theme	phospholipid	1187:1198	arg1	levels					1200:1205	breastmilk phospholipid levels	1176:1205	breastmilk phospholipid levels	1176:1205	Fecal branched SCFAs are positively associated with breastmilk phospholipid levels, free-fatty acid levels, HMO-diversity, sialylated-HMOs, 6'-sialyllactose, and disialyl-lacto-N-hexaose.
31801176	10	2	theme	breastmilk	1381:1390	arg1	lipid					1392:1396	breastmilk lipid	1381:1396	breastmilk lipid	1381:1396	CONCLUSION Fecal branched SCFA concentrations seem to be affected by breastmilk lipid and HMO composition.
31801176	11	3	theme	excessive	1489:1497	arg1	gain					1506:1509	the excessive weight gain	1485:1509	the excessive weight gain in early life	1485:1523	These differences in breastmilk metabolites may partially explain the excessive weight gain in early life.
31801176	10	4	theme	HMO	1402:1404	arg1	composition					1406:1416	HMO composition	1402:1416	HMO composition	1402:1416	CONCLUSION Fecal branched SCFA concentrations seem to be affected by breastmilk lipid and HMO composition.
31801176	0	5	with	Infants	99:105	arg1	Gain					129:132	Excessive Weight Gain	112:132	Excessive Weight Gain	112:132	Breastmilk Lipids and Oligosaccharides Influence Branched Short-Chain Fatty Acid Concentrations in Infants with Excessive Weight Gain.
31801176	1	6	theme	breastmilk	164:173	arg1	components					175:184	breastmilk components	164:184	breastmilk components associated with fecal concentration of SCFAs	164:229	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	11	7	theme	breastmilk	1440:1449	arg1	metabolites					1451:1461	breastmilk metabolites	1440:1461	breastmilk metabolites	1440:1461	These differences in breastmilk metabolites may partially explain the excessive weight gain in early life.
31801176	0	8	theme	Excessive	112:120	arg1	Gain					129:132	Excessive Weight Gain	112:132	Excessive Weight Gain	112:132	Breastmilk Lipids and Oligosaccharides Influence Branched Short-Chain Fatty Acid Concentrations in Infants with Excessive Weight Gain.
31801176	7	9	theme	transition	986:995	arg1	period					997:1002	the transition period	982:1002	the transition period from breastfeeding to complementary feeding	982:1046	Fecal SCFA concentrations are increased during the transition period from breastfeeding to complementary feeding.
31801176	8	10	theme	butyrate	1055:1062	arg1	concentration					1064:1076	Fecal butyrate concentration	1049:1076	Fecal butyrate concentration	1049:1076	Fecal butyrate concentration is higher in the NW-group at 9 months of age.
31801176	9	11	theme	free-fatty	1208:1217	arg1	levels					1224:1229	free-fatty acid levels	1208:1229	free-fatty acid levels	1208:1229	Fecal branched SCFAs are positively associated with breastmilk phospholipid levels, free-fatty acid levels, HMO-diversity, sialylated-HMOs, 6'-sialyllactose, and disialyl-lacto-N-hexaose.
31801176	6	12	from	months	911:916	arg1	HW-group					897:904	the HW-group	893:904	the HW-group at 5 months of age	893:923	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	10	13	theme	CONCLUSION	1312:1321	arg1	concentrations					1343:1356	CONCLUSION Fecal branched SCFA concentrations	1312:1356	CONCLUSION Fecal branched SCFA concentrations	1312:1356	CONCLUSION Fecal branched SCFA concentrations seem to be affected by breastmilk lipid and HMO composition.
31801176	9	14	theme	acid	1219:1222	arg1	levels					1224:1229	free-fatty acid levels	1208:1229	free-fatty acid levels	1208:1229	Fecal branched SCFAs are positively associated with breastmilk phospholipid levels, free-fatty acid levels, HMO-diversity, sialylated-HMOs, 6'-sialyllactose, and disialyl-lacto-N-hexaose.
31801176	6	15	theme	oleic	777:781	arg1	acid					771:774	α-linolenic acid	759:774	α-linolenic acid	759:774	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	6	15	theme	oleic	777:781	arg1	acid					783:786	oleic acid	777:786	oleic acid	777:786	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	2	16	theme	fecal	377:381	arg1	samples					383:389	fecal samples	377:389	fecal samples	377:389	METHODS AND RESULTS Breastmilk and fecal samples are collected from mother-infant dyads with HW (n = 11) and NW (n = 15) at 5 and 9 months of age.
31801176	0	17	theme	Weight	122:127	arg1	Gain					129:132	Excessive Weight Gain	112:132	Excessive Weight Gain	112:132	Breastmilk Lipids and Oligosaccharides Influence Branched Short-Chain Fatty Acid Concentrations in Infants with Excessive Weight Gain.
31801176	6	18	from	mothers	880:886	arg1	breastmilk					864:873	breastmilk	864:873	breastmilk from mothers from the HW-group at 5 months of age	864:923	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	6	18	from	mothers	880:886	arg1	levels					749:754	Lower levels	743:754	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age	743:923	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	7	19	theme	complementary	1026:1038	arg1	feeding					1040:1046	complementary feeding	1026:1046	complementary feeding	1026:1046	Fecal SCFA concentrations are increased during the transition period from breastfeeding to complementary feeding.
31801176	1	20	dep	SCOPE	135:139	arg1	aim					145:147	The aim	141:147	SCOPE The aim	135:147	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	4	21	theme	chemical	616:623	arg1	method					640:645	an isotope-labeled chemical derivatization method	597:645	an isotope-labeled chemical derivatization method	597:645	Fecal SCFAs are quantified using an isotope-labeled chemical derivatization method.
31801176	6	22	from	HW-group	897:904	arg1	mothers					880:886	mothers	880:886	mothers from the HW-group at 5 months of age	880:923	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	6	23	theme	acid	771:774	arg1	levels					749:754	Lower levels	743:754	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age	743:923	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	0	24	theme	Breastmilk	0:9	arg1	Lipids					11:16	Breastmilk Lipids	0:16	Breastmilk Lipids	0:16	Breastmilk Lipids and Oligosaccharides Influence Branched Short-Chain Fatty Acid Concentrations in Infants with Excessive Weight Gain.
31801176	1	25	theme	high	291:294	arg1	gain					303:306	high weight gain	291:306	high weight gain (HW)	291:311	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	1	25	theme	high	291:294	arg1	HW					309:310	HW	309:310	HW	309:310	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	6	26	theme	α-linolenic	759:769	arg1	acid					771:774	α-linolenic acid	759:774	α-linolenic acid	759:774	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	6	26	theme	α-linolenic	759:769	arg1	acid					807:810	3-oxohexadecanoic acid	789:810	3-oxohexadecanoic acid	789:810	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	6	26	theme	α-linolenic	759:769	arg1	LPE					813:815	LPE	813:815	LPE (P-16:0)	813:824	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	6	26	theme	α-linolenic	759:769	arg1	acid					783:786	oleic acid	777:786	oleic acid	777:786	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	6	26	theme	α-linolenic	759:769	arg1	PC					851:852	PC	851:852	PC (36:2)	851:859	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	6	26	theme	α-linolenic	759:769	arg1	LPC					839:841	LPC	839:841	LPC (18:0)	839:848	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	6	26	theme	α-linolenic	759:769	arg1	LPC					827:829	LPC	827:829	LPC (16:0)	827:836	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	1	27	theme	fecal	202:206	arg1	concentration					208:220	fecal concentration	202:220	fecal concentration of SCFAs	202:229	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	1	28	theme	weight	296:301	arg1	gain					303:306	high weight gain	291:306	high weight gain (HW)	291:311	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	1	28	theme	weight	296:301	arg1	HW					309:310	HW	309:310	HW	309:310	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	10	29	theme	SCFA	1338:1341	arg1	concentrations					1343:1356	CONCLUSION Fecal branched SCFA concentrations	1312:1356	CONCLUSION Fecal branched SCFA concentrations	1312:1356	CONCLUSION Fecal branched SCFA concentrations seem to be affected by breastmilk lipid and HMO composition.
31801176	11	30	from	differences	1425:1435	arg1	metabolites					1451:1461	breastmilk metabolites	1440:1461	breastmilk metabolites	1440:1461	These differences in breastmilk metabolites may partially explain the excessive weight gain in early life.
31801176	6	31	theme	3-oxohexadecanoic	789:805	arg1	acid					771:774	α-linolenic acid	759:774	α-linolenic acid	759:774	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	6	31	theme	3-oxohexadecanoic	789:805	arg1	acid					807:810	3-oxohexadecanoic acid	789:810	3-oxohexadecanoic acid	789:810	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	9	32	theme	Fecal	1124:1128	arg1	SCFAs					1139:1143	Fecal branched SCFAs	1124:1143	Fecal branched SCFAs	1124:1143	Fecal branched SCFAs are positively associated with breastmilk phospholipid levels, free-fatty acid levels, HMO-diversity, sialylated-HMOs, 6'-sialyllactose, and disialyl-lacto-N-hexaose.
31801176	2	33	theme	mother-infant	410:422	arg1	dyads					424:428	mother-infant dyads	410:428	mother-infant dyads with HW (n = 11) and NW (n = 15)	410:461	METHODS AND RESULTS Breastmilk and fecal samples are collected from mother-infant dyads with HW (n = 11) and NW (n = 15) at 5 and 9 months of age.
31801176	2	34	theme	age	484:486	arg1	months					474:479	5 and 9 months	466:479	5 and 9 months of age	466:486	METHODS AND RESULTS Breastmilk and fecal samples are collected from mother-infant dyads with HW (n = 11) and NW (n = 15) at 5 and 9 months of age.
31801176	10	35	theme	branched	1329:1336	arg1	concentrations					1343:1356	CONCLUSION Fecal branched SCFA concentrations	1312:1356	CONCLUSION Fecal branched SCFA concentrations	1312:1356	CONCLUSION Fecal branched SCFA concentrations seem to be affected by breastmilk lipid and HMO composition.
31801176	9	36	theme	breastmilk	1176:1185	arg1	levels					1200:1205	breastmilk phospholipid levels	1176:1205	breastmilk phospholipid levels	1176:1205	Fecal branched SCFAs are positively associated with breastmilk phospholipid levels, free-fatty acid levels, HMO-diversity, sialylated-HMOs, 6'-sialyllactose, and disialyl-lacto-N-hexaose.
31801176	0	37	theme	Branched	49:56	arg1	Concentrations					81:94	Branched Short-Chain Fatty Acid Concentrations	49:94	Branched Short-Chain Fatty Acid Concentrations in Infants with Excessive Weight Gain	49:132	Breastmilk Lipids and Oligosaccharides Influence Branched Short-Chain Fatty Acid Concentrations in Infants with Excessive Weight Gain.
31801176	7	38	theme	Fecal	935:939	arg1	concentrations					946:959	Fecal SCFA concentrations	935:959	Fecal SCFA concentrations	935:959	Fecal SCFA concentrations are increased during the transition period from breastfeeding to complementary feeding.
31801176	4	39	theme	isotope-labeled	600:614	arg1	method					640:645	an isotope-labeled chemical derivatization method	597:645	an isotope-labeled chemical derivatization method	597:645	Fecal SCFAs are quantified using an isotope-labeled chemical derivatization method.
31801176	3	40	theme	TOF-MS	547:552	arg1	platform					554:561	ultra-performance LC-quadrupole TOF-MS platform	515:561	ultra-performance LC-quadrupole TOF-MS platform	515:561	Breastmilk is profiled on ultra-performance LC-quadrupole TOF-MS platform.
31801176	1	41	theme	SCFAs	225:229	arg1	concentration					208:220	fecal concentration	202:220	fecal concentration of SCFAs	202:229	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	4	42	theme	derivatization	625:638	arg1	method					640:645	an isotope-labeled chemical derivatization method	597:645	an isotope-labeled chemical derivatization method	597:645	Fecal SCFAs are quantified using an isotope-labeled chemical derivatization method.
31801176	7	43	theme	SCFA	941:944	arg1	concentrations					946:959	Fecal SCFA concentrations	935:959	Fecal SCFA concentrations	935:959	Fecal SCFA concentrations are increased during the transition period from breastfeeding to complementary feeding.
31801176	0	44	from	Concentrations	81:94	arg1	Infants					99:105	Infants	99:105	Infants with Excessive Weight Gain	99:132	Breastmilk Lipids and Oligosaccharides Influence Branched Short-Chain Fatty Acid Concentrations in Infants with Excessive Weight Gain.
31801176	2	45	with	dyads	424:428	arg1	n = 15					455:460	n = 15	455:460	n = 15	455:460	METHODS AND RESULTS Breastmilk and fecal samples are collected from mother-infant dyads with HW (n = 11) and NW (n = 15) at 5 and 9 months of age.
31801176	2	45	with	dyads	424:428	arg1	n = 11					439:444	n = 11	439:444	n = 11	439:444	METHODS AND RESULTS Breastmilk and fecal samples are collected from mother-infant dyads with HW (n = 11) and NW (n = 15) at 5 and 9 months of age.
31801176	2	45	with	dyads	424:428	arg1	NW					451:452	NW	451:452	NW	451:452	METHODS AND RESULTS Breastmilk and fecal samples are collected from mother-infant dyads with HW (n = 11) and NW (n = 15) at 5 and 9 months of age.
31801176	5	46	theme	fluorescent	715:725	arg1	derivatization					727:740	fluorescent derivatization	715:740	fluorescent derivatization	715:740	Human milk oligosaccharides (HMOs) are quantified using HPLC after fluorescent derivatization.
31801176	0	47	theme	Fatty	70:74	arg1	Concentrations					81:94	Branched Short-Chain Fatty Acid Concentrations	49:94	Branched Short-Chain Fatty Acid Concentrations in Infants with Excessive Weight Gain	49:132	Breastmilk Lipids and Oligosaccharides Influence Branched Short-Chain Fatty Acid Concentrations in Infants with Excessive Weight Gain.
31801176	5	48	theme	Human	648:652	arg1	oligosaccharides					659:674	Human milk oligosaccharides	648:674	Human milk oligosaccharides (HMOs)	648:681	Human milk oligosaccharides (HMOs) are quantified using HPLC after fluorescent derivatization.
31801176	5	48	theme	Human	648:652	arg1	HMOs					677:680	HMOs	677:680	HMOs	677:680	Human milk oligosaccharides (HMOs) are quantified using HPLC after fluorescent derivatization.
31801176	3	49	theme	ultra-performance	515:531	arg1	platform					554:561	ultra-performance LC-quadrupole TOF-MS platform	515:561	ultra-performance LC-quadrupole TOF-MS platform	515:561	Breastmilk is profiled on ultra-performance LC-quadrupole TOF-MS platform.
31801176	6	50	theme	Lower	743:747	arg1	levels					749:754	Lower levels	743:754	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age	743:923	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	11	51	from	gain	1506:1509	arg1	life					1520:1523	early life	1514:1523	early life	1514:1523	These differences in breastmilk metabolites may partially explain the excessive weight gain in early life.
31801176	0	52	theme	Short-Chain	58:68	arg1	Concentrations					81:94	Branched Short-Chain Fatty Acid Concentrations	49:94	Branched Short-Chain Fatty Acid Concentrations in Infants with Excessive Weight Gain	49:132	Breastmilk Lipids and Oligosaccharides Influence Branched Short-Chain Fatty Acid Concentrations in Infants with Excessive Weight Gain.
31801176	7	53	from	breastfeeding	1009:1021	arg1	period					997:1002	the transition period	982:1002	the transition period from breastfeeding to complementary feeding	982:1046	Fecal SCFA concentrations are increased during the transition period from breastfeeding to complementary feeding.
31801176	5	54	theme	milk	654:657	arg1	oligosaccharides					659:674	Human milk oligosaccharides	648:674	Human milk oligosaccharides (HMOs)	648:681	Human milk oligosaccharides (HMOs) are quantified using HPLC after fluorescent derivatization.
31801176	5	54	theme	milk	654:657	arg1	HMOs					677:680	HMOs	677:680	HMOs	677:680	Human milk oligosaccharides (HMOs) are quantified using HPLC after fluorescent derivatization.
31801176	3	55	theme	LC-quadrupole	533:545	arg1	platform					554:561	ultra-performance LC-quadrupole TOF-MS platform	515:561	ultra-performance LC-quadrupole TOF-MS platform	515:561	Breastmilk is profiled on ultra-performance LC-quadrupole TOF-MS platform.
31801176	9	56	theme	branched	1130:1137	arg1	SCFAs					1139:1143	Fecal branched SCFAs	1124:1143	Fecal branched SCFAs	1124:1143	Fecal branched SCFAs are positively associated with breastmilk phospholipid levels, free-fatty acid levels, HMO-diversity, sialylated-HMOs, 6'-sialyllactose, and disialyl-lacto-N-hexaose.
31801176	1	57	theme	normal	317:322	arg1	NW					337:338	NW	337:338	NW	337:338	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	1	57	theme	normal	317:322	arg1	gain					331:334	normal weight gain	317:334	normal weight gain (NW)	317:339	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	11	58	theme	early	1514:1518	arg1	life					1520:1523	early life	1514:1523	early life	1514:1523	These differences in breastmilk metabolites may partially explain the excessive weight gain in early life.
31801176	10	59	theme	Fecal	1323:1327	arg1	concentrations					1343:1356	CONCLUSION Fecal branched SCFA concentrations	1312:1356	CONCLUSION Fecal branched SCFA concentrations	1312:1356	CONCLUSION Fecal branched SCFA concentrations seem to be affected by breastmilk lipid and HMO composition.
31801176	6	60	from	levels	749:754	arg1	mothers					880:886	mothers	880:886	mothers from the HW-group at 5 months of age	880:923	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	6	60	from	levels	749:754	arg1	breastmilk					864:873	breastmilk	864:873	breastmilk from mothers from the HW-group at 5 months of age	864:923	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	4	61	theme	Fecal	564:568	arg1	SCFAs					570:574	Fecal SCFAs	564:574	Fecal SCFAs	564:574	Fecal SCFAs are quantified using an isotope-labeled chemical derivatization method.
31801176	2	62	dep	METHODS	342:348	arg1	Breastmilk					362:371	Breastmilk	362:371	Breastmilk	362:371	METHODS AND RESULTS Breastmilk and fecal samples are collected from mother-infant dyads with HW (n = 11) and NW (n = 15) at 5 and 9 months of age.
31801176	2	62	dep	METHODS	342:348	arg1	samples					383:389	fecal samples	377:389	fecal samples	377:389	METHODS AND RESULTS Breastmilk and fecal samples are collected from mother-infant dyads with HW (n = 11) and NW (n = 15) at 5 and 9 months of age.
31801176	1	63	with	infants	278:284	arg1	gain					303:306	high weight gain	291:306	high weight gain (HW)	291:311	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	1	63	with	infants	278:284	arg1	NW					337:338	NW	337:338	NW	337:338	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	1	63	with	infants	278:284	arg1	gain					331:334	normal weight gain	317:334	normal weight gain (NW)	317:339	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	1	63	with	infants	278:284	arg1	HW					309:310	HW	309:310	HW	309:310	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	8	64	theme	age	1119:1121	arg1	months					1109:1114	9 months	1107:1114	9 months of age	1107:1121	Fecal butyrate concentration is higher in the NW-group at 9 months of age.
31801176	6	65	theme	age	921:923	arg1	months					911:916	5 months	909:916	5 months of age	909:923	Lower levels of α-linolenic acid, oleic acid, 3-oxohexadecanoic acid, LPE (P-16:0), LPC (16:0), LPC (18:0), PC (36:2) in breastmilk from mothers from the HW-group at 5 months of age is found.
31801176	11	66	theme	weight	1499:1504	arg1	gain					1506:1509	the excessive weight gain	1485:1509	the excessive weight gain in early life	1485:1523	These differences in breastmilk metabolites may partially explain the excessive weight gain in early life.
31801176	0	67	theme	Acid	76:79	arg1	Concentrations					81:94	Branched Short-Chain Fatty Acid Concentrations	49:94	Branched Short-Chain Fatty Acid Concentrations in Infants with Excessive Weight Gain	49:132	Breastmilk Lipids and Oligosaccharides Influence Branched Short-Chain Fatty Acid Concentrations in Infants with Excessive Weight Gain.
31801176	1	68	theme	weight	324:329	arg1	NW					337:338	NW	337:338	NW	337:338	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
31801176	1	68	theme	weight	324:329	arg1	gain					331:334	normal weight gain	317:334	normal weight gain (NW)	317:339	SCOPE The aim is to identify breastmilk components associated with fecal concentration of SCFAs and to investigate whether they differ between infants with high weight gain (HW) and normal weight gain (NW).
34577065	0	0	theme	Green	64:68	arg1	Composites					70:79	Green Composites	64:79	Green Composites	64:79	Effect of the Micronization of Pulp Fibers on the Properties of Green Composites.
34577065	6	1	theme	composites	1277:1286	arg1	manufacturing					1241:1253	the manufacturing	1237:1253	the manufacturing of entirely bio-based composites	1237:1286	The overall results show that micronization is a simple and sustainable alternative for conventional chemical treatments in the manufacturing of entirely bio-based composites.
34577065	6	2	theme	simple	1162:1167	arg1	alternative					1185:1195	a simple and sustainable alternative	1160:1195	a simple and sustainable alternative for conventional chemical treatments in the manufacturing of entirely bio-based composites	1160:1286	The overall results show that micronization is a simple and sustainable alternative for conventional chemical treatments in the manufacturing of entirely bio-based composites.
34577065	6	2	theme	simple	1162:1167	arg1	micronization					1143:1155	micronization	1143:1155	micronization	1143:1155	The overall results show that micronization is a simple and sustainable alternative for conventional chemical treatments in the manufacturing of entirely bio-based composites.
34577065	1	3	theme	natural	135:141	arg1	fibers					143:148	natural fibers	135:148	natural fibers	135:148	Green composites, composed of bio-based matrices and natural fibers, are a sustainable alternative for composites based on conventional thermoplastics and glass fibers.
34577065	1	4	theme	glass	237:241	arg1	fibers					243:248	glass fibers	237:248	glass fibers	237:248	Green composites, composed of bio-based matrices and natural fibers, are a sustainable alternative for composites based on conventional thermoplastics and glass fibers.
34577065	6	5	theme	bio-based	1267:1275	arg1	composites					1277:1286	entirely bio-based composites	1258:1286	entirely bio-based composites	1258:1286	The overall results show that micronization is a simple and sustainable alternative for conventional chemical treatments in the manufacturing of entirely bio-based composites.
34577065	3	6	theme	thermal	591:597	arg1	properties					599:608	mechanical and thermal properties	576:608	mechanical and thermal properties of the green composites	576:632	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	4	7	theme	flexural	699:706	arg1	moduli					708:713	flexural moduli	699:713	flexural moduli	699:713	Increasing fiber loads raised the tensile and flexural moduli as well as the tensile strength of the composites, while decreasing their elongation at the break and melt flow rate.
34577065	4	8	theme	Increasing	653:662	arg1	loads					670:674	Increasing fiber loads	653:674	Increasing fiber loads	653:674	Increasing fiber loads raised the tensile and flexural moduli as well as the tensile strength of the composites, while decreasing their elongation at the break and melt flow rate.
34577065	0	9	from	Effect	0:5	arg1	Properties					50:59	the Properties	46:59	the Properties of Green Composites	46:79	Effect of the Micronization of Pulp Fibers on the Properties of Green Composites.
34577065	2	10	used	used	326:329	arg2	reinforcement					334:346	reinforcement	334:346	reinforcement	334:346	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	2	10	used	used	326:329	arg2	fibers					314:319	micronized bleached Eucalyptus kraft pulp (BEKP) fibers	265:319	micronized bleached Eucalyptus kraft pulp (BEKP) fibers	265:319	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	2	11	theme	micronized	265:274	arg1	fibers					314:319	micronized bleached Eucalyptus kraft pulp (BEKP) fibers	265:319	micronized bleached Eucalyptus kraft pulp (BEKP) fibers	265:319	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	2	11	theme	micronized	265:274	arg1	reinforcement					334:346	reinforcement	334:346	reinforcement	334:346	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	4	12	theme	fiber	664:668	arg1	loads					670:674	Increasing fiber loads	653:674	Increasing fiber loads	653:674	Increasing fiber loads raised the tensile and flexural moduli as well as the tensile strength of the composites, while decreasing their elongation at the break and melt flow rate.
34577065	0	13	theme	Composites	70:79	arg1	Properties					50:59	the Properties	46:59	the Properties of Green Composites	46:79	Effect of the Micronization of Pulp Fibers on the Properties of Green Composites.
34577065	3	14	theme	aspect	468:473	arg1	influence					442:450	The influence	438:450	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites	438:632	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	5	15	theme	non-micronized	1085:1098	arg1	fibers					1105:1110	non-micronized pulp fibers	1085:1110	non-micronized pulp fibers	1085:1110	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	3	16	from	influence	442:450	arg1	morphology					528:537	the morphology	524:537	the morphology	524:537	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	3	16	from	influence	442:450	arg1	uptake					546:551	water uptake	540:551	water uptake	540:551	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	3	16	from	influence	442:450	arg1	flowability					559:569	melt flowability	554:569	melt flowability	554:569	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	3	16	from	influence	442:450	arg1	properties					599:608	mechanical and thermal properties	576:608	mechanical and thermal properties of the green composites	576:632	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	5	17	theme	micronized	865:874	arg1	fibers					876:881	the micronized fibers	861:881	the micronized fibers	861:881	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	6	18	theme	overall	1117:1123	arg1	results					1125:1131	The overall results	1113:1131	The overall results	1113:1131	The overall results show that micronization is a simple and sustainable alternative for conventional chemical treatments in the manufacturing of entirely bio-based composites.
34577065	3	19	theme	green	617:621	arg1	composites					623:632	the green composites	613:632	the green composites	613:632	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	5	20	theme	fibers	876:881	arg1	ratio					852:856	The reduced aspect ratio	833:856	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9)	833:914	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	5	21	dep	28.9	910:913	arg1	to					907:908	to	907:908	to	907:908	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	3	22	theme	composites	623:632	arg1	morphology					528:537	the morphology	524:537	the morphology	524:537	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	3	22	theme	composites	623:632	arg1	uptake					546:551	water uptake	540:551	water uptake	540:551	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	3	22	theme	composites	623:632	arg1	flowability					559:569	melt flowability	554:569	melt flowability	554:569	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	3	22	theme	composites	623:632	arg1	properties					599:608	mechanical and thermal properties	576:608	mechanical and thermal properties of the green composites	576:632	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	2	23	theme	pulp	302:305	arg1	fibers					314:319	micronized bleached Eucalyptus kraft pulp (BEKP) fibers	265:319	micronized bleached Eucalyptus kraft pulp (BEKP) fibers	265:319	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	2	23	theme	pulp	302:305	arg1	reinforcement					334:346	reinforcement	334:346	reinforcement	334:346	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	2	24	theme	biopolymeric	351:362	arg1	matrices					364:371	biopolymeric matrices	351:371	biopolymeric matrices	351:371	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	2	24	theme	biopolymeric	351:362	arg1	poly					381:384	poly	381:384	poly(lactic acid) (PLA)	381:403	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	2	24	theme	biopolymeric	351:362	arg1	poly					409:412	poly	409:412	poly(hydroxybutyrate) (PHB)	409:435	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	5	25	theme	superior	991:998	arg1	performance					1011:1021	superior mechanical performance	991:1021	superior mechanical performance	991:1021	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	4	26	theme	composites	754:763	arg1	tensile					687:693	tensile	687:693	tensile	687:693	Increasing fiber loads raised the tensile and flexural moduli as well as the tensile strength of the composites, while decreasing their elongation at the break and melt flow rate.
34577065	4	26	theme	composites	754:763	arg1	moduli					708:713	flexural moduli	699:713	flexural moduli	699:713	Increasing fiber loads raised the tensile and flexural moduli as well as the tensile strength of the composites, while decreasing their elongation at the break and melt flow rate.
34577065	4	26	theme	composites	754:763	arg1	strength					738:745	the tensile strength	726:745	the tensile and flexural moduli as well as the tensile strength of the composites	683:763	Increasing fiber loads raised the tensile and flexural moduli as well as the tensile strength of the composites, while decreasing their elongation at the break and melt flow rate.
34577065	2	27	theme	kraft	296:300	arg1	BEKP					308:311	BEKP	308:311	BEKP	308:311	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	2	27	theme	kraft	296:300	arg1	pulp					302:305	bleached Eucalyptus kraft pulp	276:305	micronized bleached Eucalyptus kraft pulp (BEKP) fibers	265:319	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	1	28	theme	sustainable	157:167	arg1	alternative					169:179	a sustainable alternative	155:179	a sustainable alternative for composites based on conventional thermoplastics and glass fibers	155:248	Green composites, composed of bio-based matrices and natural fibers, are a sustainable alternative for composites based on conventional thermoplastics and glass fibers.
34577065	1	28	theme	sustainable	157:167	arg1	composites					88:97	Green composites	82:97	Green composites	82:97	Green composites, composed of bio-based matrices and natural fibers, are a sustainable alternative for composites based on conventional thermoplastics and glass fibers.
34577065	0	29	theme	Micronization	14:26	arg1	Effect					0:5	Effect	0:5	Effect of the Micronization of Pulp Fibers on the Properties of Green Composites.	0:80	Effect of the Micronization of Pulp Fibers on the Properties of Green Composites.
34577065	4	30	theme	flow	822:825	arg1	rate					827:830	the break and melt flow rate	803:830	rate	827:830	Increasing fiber loads raised the tensile and flexural moduli as well as the tensile strength of the composites, while decreasing their elongation at the break and melt flow rate.
34577065	4	31	theme	tensile	730:736	arg1	strength					738:745	the tensile strength	726:745	the tensile and flexural moduli as well as the tensile strength of the composites	683:763	Increasing fiber loads raised the tensile and flexural moduli as well as the tensile strength of the composites, while decreasing their elongation at the break and melt flow rate.
34577065	2	32	theme	Eucalyptus	285:294	arg1	BEKP					308:311	BEKP	308:311	BEKP	308:311	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	2	32	theme	Eucalyptus	285:294	arg1	pulp					302:305	bleached Eucalyptus kraft pulp	276:305	micronized bleached Eucalyptus kraft pulp (BEKP) fibers	265:319	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	5	33	from	28.9	910:913	arg1	ratio					852:856	The reduced aspect ratio	833:856	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9)	833:914	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	5	33	from	28.9	910:913	arg1	range					891:895	the range	887:895	the range from 11.0 to 28.9	887:913	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	2	34	theme	lactic	386:391	arg1	poly					381:384	poly	381:384	poly(lactic acid) (PLA)	381:403	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	2	34	theme	lactic	386:391	arg1	acid					393:396	lactic acid	386:396	lactic acid	386:396	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	5	35	theme	reduced	837:843	arg1	ratio					852:856	The reduced aspect ratio	833:856	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9)	833:914	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	4	36	theme	melt	817:820	arg1	rate					827:830	the break and melt flow rate	803:830	rate	827:830	Increasing fiber loads raised the tensile and flexural moduli as well as the tensile strength of the composites, while decreasing their elongation at the break and melt flow rate.
34577065	3	37	theme	melt	554:557	arg1	flowability					559:569	melt flowability	554:569	melt flowability	554:569	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	2	38	theme	bleached	276:283	arg1	BEKP					308:311	BEKP	308:311	BEKP	308:311	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	2	38	theme	bleached	276:283	arg1	pulp					302:305	bleached Eucalyptus kraft pulp	276:305	micronized bleached Eucalyptus kraft pulp (BEKP) fibers	265:319	In this work, micronized bleached Eucalyptus kraft pulp (BEKP) fibers were used as reinforcement in biopolymeric matrices, namely poly(lactic acid) (PLA) and poly(hydroxybutyrate) (PHB).
34577065	0	39	theme	Pulp	31:34	arg1	Fibers					36:41	Pulp Fibers	31:41	Pulp Fibers	31:41	Effect of the Micronization of Pulp Fibers on the Properties of Green Composites.
34577065	6	40	from	treatments	1223:1232	arg1	manufacturing					1241:1253	the manufacturing	1237:1253	the manufacturing of entirely bio-based composites	1237:1286	The overall results show that micronization is a simple and sustainable alternative for conventional chemical treatments in the manufacturing of entirely bio-based composites.
34577065	6	41	theme	chemical	1214:1221	arg1	treatments					1223:1232	conventional chemical treatments	1201:1232	conventional chemical treatments in the manufacturing of entirely bio-based composites	1201:1286	The overall results show that micronization is a simple and sustainable alternative for conventional chemical treatments in the manufacturing of entirely bio-based composites.
34577065	3	42	theme	microfibers	509:519	arg1	load					459:462	load	459:462	load	459:462	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	3	42	theme	microfibers	509:519	arg1	aspect					468:473	aspect	468:473	aspect	468:473	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	6	43	theme	conventional	1201:1212	arg1	treatments					1223:1232	conventional chemical treatments	1201:1232	conventional chemical treatments in the manufacturing of entirely bio-based composites	1201:1286	The overall results show that micronization is a simple and sustainable alternative for conventional chemical treatments in the manufacturing of entirely bio-based composites.
34577065	0	44	theme	Fibers	36:41	arg1	Micronization					14:26	the Micronization	10:26	the Micronization of Pulp Fibers	10:41	Effect of the Micronization of Pulp Fibers on the Properties of Green Composites.
34577065	5	45	theme	lower	1027:1031	arg1	uptake					1039:1044	lower water uptake	1027:1044	lower water uptake	1027:1044	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	3	46	theme	mechanical	576:585	arg1	properties					599:608	mechanical and thermal properties	576:608	mechanical and thermal properties of the green composites	576:632	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	3	47	theme	treated	501:507	arg1	microfibers					509:519	the mechanically treated microfibers	484:519	the mechanically treated microfibers	484:519	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	5	48	theme	water	1033:1037	arg1	uptake					1039:1044	lower water uptake	1027:1044	lower water uptake	1027:1044	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	6	49	theme	sustainable	1173:1183	arg1	alternative					1185:1195	a simple and sustainable alternative	1160:1195	a simple and sustainable alternative for conventional chemical treatments in the manufacturing of entirely bio-based composites	1160:1286	The overall results show that micronization is a simple and sustainable alternative for conventional chemical treatments in the manufacturing of entirely bio-based composites.
34577065	6	49	theme	sustainable	1173:1183	arg1	micronization					1143:1155	micronization	1143:1155	micronization	1143:1155	The overall results show that micronization is a simple and sustainable alternative for conventional chemical treatments in the manufacturing of entirely bio-based composites.
34577065	5	50	theme	aspect	845:850	arg1	ratio					852:856	The reduced aspect ratio	833:856	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9)	833:914	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	5	51	with	composites	1069:1078	arg1	fibers					1105:1110	non-micronized pulp fibers	1085:1110	non-micronized pulp fibers	1085:1110	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	3	52	dep	load	459:462	arg1	ratio					475:479	ratio	475:479	ratio	475:479	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	3	52	dep	load	459:462	arg1	the					455:457	the	455:457	the	455:457	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	1	53	theme	Green	82:86	arg1	alternative					169:179	a sustainable alternative	155:179	a sustainable alternative for composites based on conventional thermoplastics and glass fibers	155:248	Green composites, composed of bio-based matrices and natural fibers, are a sustainable alternative for composites based on conventional thermoplastics and glass fibers.
34577065	1	53	theme	Green	82:86	arg1	composites					88:97	Green composites	82:97	Green composites	82:97	Green composites, composed of bio-based matrices and natural fibers, are a sustainable alternative for composites based on conventional thermoplastics and glass fibers.
34577065	5	54	theme	pulp	1100:1103	arg1	fibers					1105:1110	non-micronized pulp fibers	1085:1110	non-micronized pulp fibers	1085:1110	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	3	55	theme	water	540:544	arg1	uptake					546:551	water uptake	540:551	water uptake	540:551	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	1	56	theme	bio-based	112:120	arg1	matrices					122:129	bio-based matrices	112:129	bio-based matrices	112:129	Green composites, composed of bio-based matrices and natural fibers, are a sustainable alternative for composites based on conventional thermoplastics and glass fibers.
34577065	1	57	theme	conventional	205:216	arg1	thermoplastics					218:231	conventional thermoplastics	205:231	conventional thermoplastics	205:231	Green composites, composed of bio-based matrices and natural fibers, are a sustainable alternative for composites based on conventional thermoplastics and glass fibers.
34577065	5	58	theme	mechanical	1000:1009	arg1	performance					1011:1021	superior mechanical performance	991:1021	superior mechanical performance	991:1021	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	5	59	from	ratio	852:856	arg1	range					891:895	the range	887:895	the range from 11.0 to 28.9	887:913	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	5	59	from	ratio	852:856	arg1	28.9					910:913	28.9	910:913	28.9	910:913	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	5	60	from	embedment	931:939	arg1	matrices					948:955	the matrices	944:955	the matrices	944:955	The reduced aspect ratio of the micronized fibers (in the range from 11.0 to 28.9) improved their embedment in the matrices, particularly for PHB, leading to superior mechanical performance and lower water uptake when compared with the composites with non-micronized pulp fibers.
34577065	3	61	theme	load	459:462	arg1	influence					442:450	The influence	438:450	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites	438:632	The influence of the load and aspect ratio of the mechanically treated microfibers on the morphology, water uptake, melt flowability, and mechanical and thermal properties of the green composites were investigated.
34577065	4	62	dep	tensile	687:693	arg1	the					683:685	the	683:685	the	683:685	Increasing fiber loads raised the tensile and flexural moduli as well as the tensile strength of the composites, while decreasing their elongation at the break and melt flow rate.
34500709	6	0	theme	colloidal	877:885	arg1	stability					887:895	good colloidal stability	872:895	good colloidal stability shown by the zeta potential results	872:931	The TEM and FT-IR results showed the successful isolation of CNF from bamboo using this method, with good colloidal stability shown by the zeta potential results.
34500709	4	1	used	used	569:572	arg2	CNF					561:563	Commercial CNF	550:563	Commercial CNF	550:563	Commercial CNF was used as a reference to evaluate the effectiveness of the method.
34500709	4	1	used	used	569:572	arg2	reference					579:587	a reference	577:587	a reference	577:587	Commercial CNF was used as a reference to evaluate the effectiveness of the method.
34500709	10	2	theme	wettability	1346:1356	arg1	properties					1358:1367	the physical, mechanical, thermal, and wettability properties	1307:1367	the physical, mechanical, thermal, and wettability properties	1307:1367	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	10	2	theme	wettability	1346:1356	arg1	different					1388:1396	different	1388:1396	different	1388:1396	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	2	3	theme	defibrillation	350:363	arg1	pretreatment					365:376	a fibre bundle defibrillation pretreatment	335:376	a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo	335:413	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	2	3	theme	defibrillation	350:363	arg1	dioxide					324:330	supercritical carbon dioxide	303:330	supercritical carbon dioxide	303:330	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	1	4	theme	reinforcement	250:262	arg1	ability					264:270	its functional reinforcement ability	235:270	its functional reinforcement ability in composites	235:284	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	9	5	dep	crystallinity	1201:1213	arg1	index					1215:1219	index	1215:1219	a higher crystallinity index	1192:1219	The bamboo CNF had a smaller fibre size and a higher crystallinity index than the commercial CNF.
34500709	13	6	theme	CNFs	1776:1779	arg1	properties					1753:1762	The physical properties	1740:1762	The physical properties of isolated CNFs	1740:1779	The physical properties of isolated CNFs are partly dependent on their source and production method, among other factors.
34500709	13	6	theme	CNFs	1776:1779	arg1	dependent					1792:1800	dependent	1792:1800	dependent	1792:1800	The physical properties of isolated CNFs are partly dependent on their source and production method, among other factors.
34500709	5	7	theme	physical	638:645	arg1	properties					685:694	The physical, mechanical, thermal, and wettability properties	634:694	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin	634:749	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin were also analysed.
34500709	9	8	theme	bamboo	1152:1157	arg1	CNF					1159:1161	The bamboo CNF	1148:1161	The bamboo CNF	1148:1161	The bamboo CNF had a smaller fibre size and a higher crystallinity index than the commercial CNF.
34500709	9	9	contain	had	1163:1165	arg2	size					1183:1186	a smaller fibre size	1167:1186	a smaller fibre size	1167:1186	The bamboo CNF had a smaller fibre size and a higher crystallinity index than the commercial CNF.
34500709	9	9	contain	had	1163:1165	arg1	CNF					1159:1161	The bamboo CNF	1148:1161	The bamboo CNF	1148:1161	The bamboo CNF had a smaller fibre size and a higher crystallinity index than the commercial CNF.
34500709	9	9	contain	had	1163:1165	arg2	crystallinity					1201:1213	a higher crystallinity	1192:1213	a higher crystallinity index	1192:1219	The bamboo CNF had a smaller fibre size and a higher crystallinity index than the commercial CNF.
34500709	14	10	theme	various	1895:1901	arg1	applications					1914:1925	various industrial applications	1895:1925	various industrial applications	1895:1925	These composites can be used for various industrial applications, including packaging.
34500709	14	10	theme	various	1895:1901	arg1	packaging					1938:1946	packaging	1938:1946	packaging	1938:1946	These composites can be used for various industrial applications, including packaging.
34500709	13	11	theme	physical	1744:1751	arg1	properties					1753:1762	The physical properties	1740:1762	The physical properties of isolated CNFs	1740:1779	The physical properties of isolated CNFs are partly dependent on their source and production method, among other factors.
34500709	13	11	theme	physical	1744:1751	arg1	dependent					1792:1800	dependent	1792:1800	dependent	1792:1800	The physical properties of isolated CNFs are partly dependent on their source and production method, among other factors.
34500709	9	12	theme	smaller	1169:1175	arg1	size					1183:1186	a smaller fibre size	1167:1186	a smaller fibre size	1167:1186	The bamboo CNF had a smaller fibre size and a higher crystallinity index than the commercial CNF.
34500709	2	13	theme	carbon	317:322	arg1	pretreatment					365:376	a fibre bundle defibrillation pretreatment	335:376	a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo	335:413	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	2	13	theme	carbon	317:322	arg1	dioxide					324:330	supercritical carbon dioxide	303:330	supercritical carbon dioxide	303:330	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	1	14	theme	cellulose	190:198	arg1	CNF					211:213	CNF	211:213	CNF	211:213	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	1	14	theme	cellulose	190:198	arg1	nanofibre					200:208	cellulose nanofibre	190:208	cellulose nanofibre (CNF)	190:214	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	14	15	used	used	1886:1889	arg2	composites					1868:1877	These composites	1862:1877	These composites	1862:1877	These composites can be used for various industrial applications, including packaging.
34500709	6	16	theme	potential	915:923	arg1	results					925:931	the zeta potential results	906:931	the zeta potential results	906:931	The TEM and FT-IR results showed the successful isolation of CNF from bamboo using this method, with good colloidal stability shown by the zeta potential results.
34500709	5	17	theme	mechanical	648:657	arg1	properties					685:694	The physical, mechanical, thermal, and wettability properties	634:694	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin	634:749	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin were also analysed.
34500709	7	18	theme	bamboo	965:970	arg1	CNF					972:974	the isolated bamboo CNF	952:974	the isolated bamboo CNF	952:974	The properties of the isolated bamboo CNF were similar to the commercial type.
34500709	5	19	theme	thermal	660:666	arg1	properties					685:694	The physical, mechanical, thermal, and wettability properties	634:694	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin	634:749	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin were also analysed.
34500709	12	20	theme	reinforcement	1700:1712	arg1	ability					1714:1720	its reinforcement ability	1696:1720	its reinforcement ability	1696:1720	This indicates that the physical properties (fibre size and crystallinity) of an isolated CNF significantly affect its reinforcement ability in biocomposites.
34500709	5	21	theme	CNF-reinforced	725:738	arg1	PLA/chitin					740:749	the bamboo and commercial CNF-reinforced PLA/chitin	699:749	PLA/chitin	740:749	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin were also analysed.
34500709	9	22	theme	commercial	1230:1239	arg1	CNF					1241:1243	the commercial CNF	1226:1243	the commercial CNF	1226:1243	The bamboo CNF had a smaller fibre size and a higher crystallinity index than the commercial CNF.
34500709	1	23	theme	fibre	152:156	arg1	dimension					158:166	the fibre dimension	148:166	the fibre dimension	148:166	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	11	24	theme	bamboo	1486:1491	arg1	biocomposites					1497:1509	bamboo CNF biocomposites	1486:1509	bamboo CNF biocomposites	1486:1509	The properties of bamboo CNF biocomposites were significantly better than those of commercial CNF biocomposites.
34500709	13	25	dep	source	1811:1816	arg1	method					1833:1838	method	1833:1838	method	1833:1838	The physical properties of isolated CNFs are partly dependent on their source and production method, among other factors.
34500709	12	26	theme	CNF	1671:1673	arg1	crystallinity					1641:1653	crystallinity	1641:1653	crystallinity	1641:1653	This indicates that the physical properties (fibre size and crystallinity) of an isolated CNF significantly affect its reinforcement ability in biocomposites.
34500709	12	26	theme	CNF	1671:1673	arg1	properties					1614:1623	the physical properties	1601:1623	the physical properties (fibre size and crystallinity) of an isolated CNF	1601:1673	This indicates that the physical properties (fibre size and crystallinity) of an isolated CNF significantly affect its reinforcement ability in biocomposites.
34500709	12	26	theme	CNF	1671:1673	arg1	size					1632:1635	size	1632:1635	size	1632:1635	This indicates that the physical properties (fibre size and crystallinity) of an isolated CNF significantly affect its reinforcement ability in biocomposites.
34500709	11	27	theme	CNF	1493:1495	arg1	biocomposites					1497:1509	bamboo CNF biocomposites	1486:1509	bamboo CNF biocomposites	1486:1509	The properties of bamboo CNF biocomposites were significantly better than those of commercial CNF biocomposites.
34500709	13	28	theme	other	1847:1851	arg1	factors					1853:1859	other factors	1847:1859	other factors	1847:1859	The physical properties of isolated CNFs are partly dependent on their source and production method, among other factors.
34500709	10	29	from	biocomposite	1282:1293	arg1	results					1250:1256	The results	1246:1256	The results from the CNF-reinforced biocomposite	1246:1293	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	2	30	theme	physical	440:447	arg1	properties					449:458	its physical properties	436:458	its physical properties	436:458	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	0	31	theme	Properties	78:87	arg1	Isolation					29:37	Supercritical Carbon Dioxide Isolation	0:37	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.	0:113	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.
34500709	0	32	theme	Supercritical	0:12	arg1	Dioxide					21:27	Supercritical Carbon Dioxide	0:27	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.	0:113	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.
34500709	6	33	theme	TEM	775:777	arg1	results					789:795	The TEM and FT-IR results	771:795	The TEM and FT-IR results	771:795	The TEM and FT-IR results showed the successful isolation of CNF from bamboo using this method, with good colloidal stability shown by the zeta potential results.
34500709	0	34	theme	Dioxide	21:27	arg1	Isolation					29:37	Supercritical Carbon Dioxide Isolation	0:37	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.	0:113	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.
34500709	8	35	theme	fibre	1026:1030	arg1	distribution					1041:1052	the fibre diameter distribution	1022:1052	the fibre diameter distribution	1022:1052	However, the fibre diameter distribution and the crystallinity index significantly differed between the bamboo and the commercial CNF.
34500709	1	36	theme	physical	119:126	arg1	properties					128:137	The physical properties	115:137	The physical properties	115:137	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	1	36	theme	physical	119:126	arg1	dimension					158:166	the fibre dimension	148:166	the fibre dimension	148:166	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	1	36	theme	physical	119:126	arg1	significant					220:230	significant	220:230	significant	220:230	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	1	36	theme	physical	119:126	arg1	crystallinity					172:184	crystallinity	172:184	crystallinity	172:184	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	12	37	theme	fibre	1626:1630	arg1	properties					1614:1623	the physical properties	1601:1623	the physical properties (fibre size and crystallinity) of an isolated CNF	1601:1673	This indicates that the physical properties (fibre size and crystallinity) of an isolated CNF significantly affect its reinforcement ability in biocomposites.
34500709	12	37	theme	fibre	1626:1630	arg1	size					1632:1635	size	1632:1635	size	1632:1635	This indicates that the physical properties (fibre size and crystallinity) of an isolated CNF significantly affect its reinforcement ability in biocomposites.
34500709	10	38	theme	crystallinity	1445:1457	arg1	indices					1459:1465	crystallinity indices	1445:1465	crystallinity indices	1445:1465	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	6	39	theme	CNF	832:834	arg1	isolation					819:827	the successful isolation	804:827	the successful isolation of CNF from bamboo using this method	804:864	The TEM and FT-IR results showed the successful isolation of CNF from bamboo using this method, with good colloidal stability shown by the zeta potential results.
34500709	0	40	theme	Enhancement	66:76	arg1	Properties					78:87	Enhancement Properties	66:87	Enhancement Properties	66:87	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.
34500709	2	41	theme	bundle	343:348	arg1	pretreatment					365:376	a fibre bundle defibrillation pretreatment	335:376	a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo	335:413	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	2	41	theme	bundle	343:348	arg1	dioxide					324:330	supercritical carbon dioxide	303:330	supercritical carbon dioxide	303:330	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	0	42	theme	Nanofibre	52:60	arg1	Isolation					29:37	Supercritical Carbon Dioxide Isolation	0:37	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.	0:113	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.
34500709	2	43	used	used	298:301	arg2	study					292:296	This study	287:296	This study	287:296	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	11	44	theme	CNF	1562:1564	arg1	biocomposites					1566:1578	commercial CNF biocomposites	1551:1578	commercial CNF biocomposites	1551:1578	The properties of bamboo CNF biocomposites were significantly better than those of commercial CNF biocomposites.
34500709	10	45	theme	mechanical	1321:1330	arg1	properties					1358:1367	the physical, mechanical, thermal, and wettability properties	1307:1367	the physical, mechanical, thermal, and wettability properties	1307:1367	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	10	45	theme	mechanical	1321:1330	arg1	different					1388:1396	different	1388:1396	different	1388:1396	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	5	46	theme	PLA/chitin	740:749	arg1	properties					685:694	The physical, mechanical, thermal, and wettability properties	634:694	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin	634:749	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin were also analysed.
34500709	10	47	theme	physical	1311:1318	arg1	properties					1358:1367	the physical, mechanical, thermal, and wettability properties	1307:1367	the physical, mechanical, thermal, and wettability properties	1307:1367	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	10	47	theme	physical	1311:1318	arg1	different					1388:1396	different	1388:1396	different	1388:1396	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	3	48	theme	zeta	504:507	arg1	potential					509:517	zeta potential	504:517	zeta potential	504:517	The isolated CNF was characterised through zeta potential, TEM, XRD, and FT-IR analysis.
34500709	1	49	theme	functional	239:248	arg1	ability					264:270	its functional reinforcement ability	235:270	its functional reinforcement ability in composites	235:284	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	6	50	theme	good	872:875	arg1	stability					887:895	good colloidal stability	872:895	good colloidal stability shown by the zeta potential results	872:931	The TEM and FT-IR results showed the successful isolation of CNF from bamboo using this method, with good colloidal stability shown by the zeta potential results.
34500709	13	51	theme	isolated	1767:1774	arg1	CNFs					1776:1779	isolated CNFs	1767:1779	isolated CNFs	1767:1779	The physical properties of isolated CNFs are partly dependent on their source and production method, among other factors.
34500709	6	52	theme	FT-IR	783:787	arg1	results					789:795	The TEM and FT-IR results	771:795	The TEM and FT-IR results	771:795	The TEM and FT-IR results showed the successful isolation of CNF from bamboo using this method, with good colloidal stability shown by the zeta potential results.
34500709	10	53	theme	thermal	1333:1339	arg1	properties					1358:1367	the physical, mechanical, thermal, and wettability properties	1307:1367	the physical, mechanical, thermal, and wettability properties	1307:1367	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	10	53	theme	thermal	1333:1339	arg1	different					1388:1396	different	1388:1396	different	1388:1396	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	14	54	theme	industrial	1903:1912	arg1	applications					1914:1925	various industrial applications	1895:1925	various industrial applications	1895:1925	These composites can be used for various industrial applications, including packaging.
34500709	14	54	theme	industrial	1903:1912	arg1	packaging					1938:1946	packaging	1938:1946	packaging	1938:1946	These composites can be used for various industrial applications, including packaging.
34500709	8	55	theme	commercial	1132:1141	arg1	CNF					1143:1145	the commercial CNF	1128:1145	the commercial CNF	1128:1145	However, the fibre diameter distribution and the crystallinity index significantly differed between the bamboo and the commercial CNF.
34500709	4	56	theme	method	626:631	arg1	effectiveness					605:617	the effectiveness	601:617	the effectiveness of the method	601:631	Commercial CNF was used as a reference to evaluate the effectiveness of the method.
34500709	6	57	from	bamboo	841:846	arg1	isolation					819:827	the successful isolation	804:827	the successful isolation of CNF from bamboo using this method	804:864	The TEM and FT-IR results showed the successful isolation of CNF from bamboo using this method, with good colloidal stability shown by the zeta potential results.
34500709	1	58	from	ability	264:270	arg1	composites					275:284	composites	275:284	composites	275:284	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	9	59	theme	fibre	1177:1181	arg1	size					1183:1186	a smaller fibre size	1167:1186	a smaller fibre size	1167:1186	The bamboo CNF had a smaller fibre size and a higher crystallinity index than the commercial CNF.
34500709	2	60	theme	supercritical	303:315	arg1	pretreatment					365:376	a fibre bundle defibrillation pretreatment	335:376	a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo	335:413	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	2	60	theme	supercritical	303:315	arg1	dioxide					324:330	supercritical carbon dioxide	303:330	supercritical carbon dioxide	303:330	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	1	61	theme	nanofibre	200:208	arg1	properties					128:137	The physical properties	115:137	The physical properties	115:137	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	1	61	theme	nanofibre	200:208	arg1	dimension					158:166	the fibre dimension	148:166	the fibre dimension	148:166	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	1	61	theme	nanofibre	200:208	arg1	significant					220:230	significant	220:230	significant	220:230	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	1	61	theme	nanofibre	200:208	arg1	crystallinity					172:184	crystallinity	172:184	crystallinity	172:184	The physical properties, such as the fibre dimension and crystallinity, of cellulose nanofibre (CNF) are significant to its functional reinforcement ability in composites.
34500709	10	62	from	variations	1409:1418	arg1	indices					1459:1465	crystallinity indices	1445:1465	crystallinity indices	1445:1465	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	10	62	from	variations	1409:1418	arg1	sizes					1435:1439	their fibre sizes	1423:1439	their fibre sizes	1423:1439	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	12	63	dep	properties	1614:1623	arg1	crystallinity					1641:1653	crystallinity	1641:1653	crystallinity	1641:1653	This indicates that the physical properties (fibre size and crystallinity) of an isolated CNF significantly affect its reinforcement ability in biocomposites.
34500709	12	63	dep	properties	1614:1623	arg1	properties					1614:1623	the physical properties	1601:1623	the physical properties (fibre size and crystallinity) of an isolated CNF	1601:1673	This indicates that the physical properties (fibre size and crystallinity) of an isolated CNF significantly affect its reinforcement ability in biocomposites.
34500709	12	63	dep	properties	1614:1623	arg1	size					1632:1635	size	1632:1635	size	1632:1635	This indicates that the physical properties (fibre size and crystallinity) of an isolated CNF significantly affect its reinforcement ability in biocomposites.
34500709	5	64	theme	wettability	673:683	arg1	properties					685:694	The physical, mechanical, thermal, and wettability properties	634:694	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin	634:749	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin were also analysed.
34500709	6	65	theme	zeta	910:913	arg1	potential					915:923	the zeta potential	906:923	the zeta potential results	906:931	The TEM and FT-IR results showed the successful isolation of CNF from bamboo using this method, with good colloidal stability shown by the zeta potential results.
34500709	7	66	theme	commercial	996:1005	arg1	type					1007:1010	the commercial type	992:1010	the commercial type	992:1010	The properties of the isolated bamboo CNF were similar to the commercial type.
34500709	9	67	theme	higher	1194:1199	arg1	crystallinity					1201:1213	a higher crystallinity	1192:1213	a higher crystallinity index	1192:1219	The bamboo CNF had a smaller fibre size and a higher crystallinity index than the commercial CNF.
34500709	7	68	theme	CNF	972:974	arg1	properties					938:947	The properties	934:947	The properties of the isolated bamboo CNF	934:974	The properties of the isolated bamboo CNF were similar to the commercial type.
34500709	7	68	theme	CNF	972:974	arg1	similar					981:987	similar	981:987	similar	981:987	The properties of the isolated bamboo CNF were similar to the commercial type.
34500709	3	69	theme	FT-IR	534:538	arg1	analysis					540:547	FT-IR analysis	534:547	FT-IR analysis	534:547	The isolated CNF was characterised through zeta potential, TEM, XRD, and FT-IR analysis.
34500709	5	70	theme	commercial	714:723	arg1	PLA/chitin					740:749	the bamboo and commercial CNF-reinforced PLA/chitin	699:749	PLA/chitin	740:749	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin were also analysed.
34500709	7	71	theme	isolated	956:963	arg1	CNF					972:974	the isolated bamboo CNF	952:974	the isolated bamboo CNF	952:974	The properties of the isolated bamboo CNF were similar to the commercial type.
34500709	0	72	from	Isolation	29:37	arg1	Composites					103:112	Biopolymer Composites	92:112	Biopolymer Composites	92:112	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.
34500709	0	73	theme	Biopolymer	92:101	arg1	Composites					103:112	Biopolymer Composites	92:112	Biopolymer Composites	92:112	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.
34500709	12	74	theme	isolated	1662:1669	arg1	CNF					1671:1673	an isolated CNF	1659:1673	an isolated CNF	1659:1673	This indicates that the physical properties (fibre size and crystallinity) of an isolated CNF significantly affect its reinforcement ability in biocomposites.
34500709	5	75	theme	bamboo	703:708	arg1	properties					685:694	The physical, mechanical, thermal, and wettability properties	634:694	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin	634:749	The physical, mechanical, thermal, and wettability properties of the bamboo and commercial CNF-reinforced PLA/chitin were also analysed.
34500709	10	76	theme	fibre	1429:1433	arg1	sizes					1435:1439	their fibre sizes	1423:1439	their fibre sizes	1423:1439	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	2	77	theme	CNF	399:401	arg1	isolation					386:394	the isolation	382:394	the isolation of CNF from bamboo	382:413	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	0	78	theme	Carbon	14:19	arg1	Dioxide					21:27	Supercritical Carbon Dioxide	0:27	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.	0:113	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.
34500709	10	79	theme	CNF-reinforced	1267:1280	arg1	biocomposite					1282:1293	the CNF-reinforced biocomposite	1263:1293	the CNF-reinforced biocomposite	1263:1293	The results from the CNF-reinforced biocomposite showed that the physical, mechanical, thermal, and wettability properties were significantly different due to the variations in their fibre sizes and crystallinity indices.
34500709	8	80	theme	diameter	1032:1039	arg1	distribution					1041:1052	the fibre diameter distribution	1022:1052	the fibre diameter distribution	1022:1052	However, the fibre diameter distribution and the crystallinity index significantly differed between the bamboo and the commercial CNF.
34500709	12	81	theme	physical	1605:1612	arg1	crystallinity					1641:1653	crystallinity	1641:1653	crystallinity	1641:1653	This indicates that the physical properties (fibre size and crystallinity) of an isolated CNF significantly affect its reinforcement ability in biocomposites.
34500709	12	81	theme	physical	1605:1612	arg1	properties					1614:1623	the physical properties	1601:1623	the physical properties (fibre size and crystallinity) of an isolated CNF	1601:1673	This indicates that the physical properties (fibre size and crystallinity) of an isolated CNF significantly affect its reinforcement ability in biocomposites.
34500709	12	81	theme	physical	1605:1612	arg1	size					1632:1635	size	1632:1635	size	1632:1635	This indicates that the physical properties (fibre size and crystallinity) of an isolated CNF significantly affect its reinforcement ability in biocomposites.
34500709	4	82	theme	Commercial	550:559	arg1	reference					579:587	a reference	577:587	a reference	577:587	Commercial CNF was used as a reference to evaluate the effectiveness of the method.
34500709	4	82	theme	Commercial	550:559	arg1	CNF					561:563	Commercial CNF	550:563	Commercial CNF	550:563	Commercial CNF was used as a reference to evaluate the effectiveness of the method.
34500709	3	83	theme	isolated	465:472	arg1	CNF					474:476	The isolated CNF	461:476	The isolated CNF	461:476	The isolated CNF was characterised through zeta potential, TEM, XRD, and FT-IR analysis.
34500709	0	84	theme	Cellulose	42:50	arg1	Nanofibre					52:60	Cellulose Nanofibre	42:60	Cellulose Nanofibre	42:60	Supercritical Carbon Dioxide Isolation of Cellulose Nanofibre and Enhancement Properties in Biopolymer Composites.
34500709	8	85	theme	crystallinity	1062:1074	arg1	index					1076:1080	the crystallinity index	1058:1080	the crystallinity index	1058:1080	However, the fibre diameter distribution and the crystallinity index significantly differed between the bamboo and the commercial CNF.
34500709	11	86	theme	commercial	1551:1560	arg1	biocomposites					1566:1578	commercial CNF biocomposites	1551:1578	commercial CNF biocomposites	1551:1578	The properties of bamboo CNF biocomposites were significantly better than those of commercial CNF biocomposites.
34500709	2	87	theme	fibre	337:341	arg1	pretreatment					365:376	a fibre bundle defibrillation pretreatment	335:376	a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo	335:413	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	2	87	theme	fibre	337:341	arg1	dioxide					324:330	supercritical carbon dioxide	303:330	supercritical carbon dioxide	303:330	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	6	88	theme	successful	808:817	arg1	isolation					819:827	the successful isolation	804:827	the successful isolation of CNF from bamboo using this method	804:864	The TEM and FT-IR results showed the successful isolation of CNF from bamboo using this method, with good colloidal stability shown by the zeta potential results.
34500709	2	89	from	bamboo	408:413	arg1	isolation					386:394	the isolation	382:394	the isolation of CNF from bamboo	382:413	This study used supercritical carbon dioxide as a fibre bundle defibrillation pretreatment for the isolation of CNF from bamboo, in order to enhance its physical properties.
34500709	11	90	theme	biocomposites	1497:1509	arg1	properties					1472:1481	The properties	1468:1481	The properties of bamboo CNF biocomposites	1468:1509	The properties of bamboo CNF biocomposites were significantly better than those of commercial CNF biocomposites.
34500709	11	90	theme	biocomposites	1497:1509	arg1	better					1530:1535	better	1530:1535	better	1530:1535	The properties of bamboo CNF biocomposites were significantly better than those of commercial CNF biocomposites.
32486501	2	0	theme	capable	594:600	arg1	packaging					584:592	intelligent packaging	572:592	intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red	572:723	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	9	1	theme	different	1703:1711	arg1	pH					1713:1714	different pH	1703:1714	different pH	1703:1714	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	1	2	theme	natural	251:257	arg1	characteristics					259:273	natural characteristics	251:273	natural characteristics	251:273	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	2	3	theme	intelligent	572:582	arg1	packaging					584:592	intelligent packaging	572:592	intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red	572:723	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	11	4	contain	had	2282:2284	arg2	effect					2300:2305	a significant effect	2286:2305	a significant effect	2286:2305	The changes in pH alone did not statistically influence the color coordinates measured at the analyzed ratio; however, variations in pH associated with other factors had a significant effect on visual color changes, and observations were described.
32486501	11	4	contain	had	2282:2284	arg1	variations					2235:2244	variations	2235:2244	variations in pH associated with other factors	2235:2280	The changes in pH alone did not statistically influence the color coordinates measured at the analyzed ratio; however, variations in pH associated with other factors had a significant effect on visual color changes, and observations were described.
32486501	1	5	dep	those	417:421	arg1	needs					423:427	needs	423:427	needs	423:427	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	6	6	theme	study	1172:1176	arg1	range					1178:1182	this study range	1167:1182	this study range	1167:1182	of cellulose-acetate) and PDA (0-60 mg) were analyzed to optimize the conditions for the best color transitioning at this study range.
32486501	10	7	theme	°C	2081:2082	arg1	°C					2088:2089	100 °C ± 2 °C	2077:2089	100 °C ± 2 °C of temperature exposure	2077:2113	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	12	8	theme	intelligent	2475:2485	arg1	packaging					2487:2495	intelligent packaging	2475:2495	intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety	2475:2626	PDA films were optimized to maximize color change in order to obtain a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety.
32486501	12	9	theme	cheap	2436:2440	arg1	technology					2453:2462	a cheap and simple technology	2434:2462	a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety	2434:2626	PDA films were optimized to maximize color change in order to obtain a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety.
32486501	3	10	dep	development	751:761	arg1	the					747:749	the	747:749	the	747:749	This work focused on the development and optimization of an intelligent packaging constituted of a polymeric matrix of cellulose acetate-based incorporated with PDA as the substance sensor.
32486501	1	11	contain	have	309:312	arg1	demand					222:227	the demand	218:227	the demand for new products with natural characteristics, safe conditions and traceability	218:307	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	1	11	contain	have	309:312	arg2	researches					321:330	driven researches	314:330	driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs	314:427	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	1	11	contain	have	309:312	arg1	growth					186:191	Global growth	179:191	Global growth of the food industry	179:212	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	1	12	theme	industry	205:212	arg1	demand					222:227	the demand	218:227	the demand for new products with natural characteristics, safe conditions and traceability	218:307	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	1	12	theme	industry	205:212	arg1	growth					186:191	Global growth	179:191	Global growth of the food industry	179:212	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	4	13	theme	Cellulose	916:924	arg1	films					934:938	Cellulose acetate films	916:938	Cellulose acetate films (3% wt.)	916:947	Cellulose acetate films (3% wt.)
32486501	6	14	theme	best	1139:1142	arg1	color					1144:1148	the best color	1135:1148	the best color transitioning at this study range	1135:1182	of cellulose-acetate) and PDA (0-60 mg) were analyzed to optimize the conditions for the best color transitioning at this study range.
32486501	10	15	theme	film	1957:1960	arg1	conditions					1962:1971	The optimal film conditions	1945:1971	The optimal film conditions	1945:1971	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	10	16	theme	±	2084:2084	arg1	°C					2088:2089	100 °C ± 2 °C	2077:2089	100 °C ± 2 °C of temperature exposure	2077:2113	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	9	17	theme	color	1779:1783	arg1	changes					1785:1791	the color changes	1775:1791	the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix	1775:1880	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	2	18	from	changes	636:642	arg1	foods					647:651	foods	647:651	foods	647:651	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	2	18	from	changes	636:642	arg1	environment					666:676	their environment	660:676	their environment	660:676	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	3	19	theme	polymeric	825:833	arg1	matrix					835:840	a polymeric matrix	823:840	a polymeric matrix of cellulose	823:853	This work focused on the development and optimization of an intelligent packaging constituted of a polymeric matrix of cellulose acetate-based incorporated with PDA as the substance sensor.
32486501	10	20	theme	exposure	2106:2113	arg1	°C					2088:2089	100 °C ± 2 °C	2077:2089	100 °C ± 2 °C of temperature exposure	2077:2113	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	11	21	theme	visual	2310:2315	arg1	changes					2323:2329	visual color changes	2310:2329	visual color changes	2310:2329	The changes in pH alone did not statistically influence the color coordinates measured at the analyzed ratio; however, variations in pH associated with other factors had a significant effect on visual color changes, and observations were described.
32486501	7	22	theme	Central	1273:1279	arg1	CCD					1300:1302	CCD	1300:1302	CCD	1300:1302	The compound amounts incorporated into polymeric matrices were established according to Central Composite Designs (CCD).
32486501	7	22	theme	Central	1273:1279	arg1	Designs					1291:1297	Central Composite Designs	1273:1297	Central Composite Designs (CCD)	1273:1303	The compound amounts incorporated into polymeric matrices were established according to Central Composite Designs (CCD).
32486501	2	23	theme	due	678:680	arg1	changes					636:642	chemical or biochemical changes	612:642	chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red	612:723	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	11	24	theme	color	2176:2180	arg1	coordinates					2182:2192	the color coordinates	2172:2192	the color coordinates measured at the analyzed ratio	2172:2223	The changes in pH alone did not statistically influence the color coordinates measured at the analyzed ratio; however, variations in pH associated with other factors had a significant effect on visual color changes, and observations were described.
32486501	12	25	theme	quality	2592:2598	arg1	control					2600:2606	the food quality control	2583:2606	the food quality control	2583:2606	PDA films were optimized to maximize color change in order to obtain a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety.
32486501	8	26	theme	PDA	1384:1386	arg1	time					1376:1379	the polymerization time	1357:1379	the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing	1357:1548	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	12	27	theme	PDA	2365:2367	arg1	films					2369:2373	PDA films	2365:2373	PDA films	2365:2373	PDA films were optimized to maximize color change in order to obtain a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety.
32486501	2	28	used	used	556:559	arg2	material					467:474	a synthetic material	455:474	a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red	455:723	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	2	28	used	used	556:559	arg2	substance					532:540	a sensor substance	523:540	a sensor substance	523:540	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	9	29	theme	film	1585:1588	arg1	coordinates					1596:1606	film color coordinates	1585:1606	film color coordinates	1585:1606	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	8	30	theme	UV	1394:1395	arg1	light					1397:1401	UV light	1394:1401	UV light exposition (0-60 min)	1394:1423	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	2	31	theme	color	691:695	arg1	transition					697:706	PDA's color transition	685:706	PDA's color transition from blue to red	685:723	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	3	32	theme	packaging	798:806	arg1	optimization					767:778	optimization	767:778	optimization	767:778	This work focused on the development and optimization of an intelligent packaging constituted of a polymeric matrix of cellulose acetate-based incorporated with PDA as the substance sensor.
32486501	3	32	theme	packaging	798:806	arg1	development					751:761	development	751:761	development	751:761	This work focused on the development and optimization of an intelligent packaging constituted of a polymeric matrix of cellulose acetate-based incorporated with PDA as the substance sensor.
32486501	0	33	theme	Packaging	71:79	arg1	Material					81:88	an Intelligent Packaging Material	56:88	an Intelligent Packaging Material	56:88	Development and Evaluation of the Chromatic Behavior of an Intelligent Packaging Material Based on Cellulose Acetate Incorporated with Polydiacetylene for an Efficient Packaging.
32486501	9	34	theme	TEC	1829:1831	arg1	concentrations					1833:1846	TEC concentrations	1829:1846	TEC concentrations	1829:1846	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	11	35	dep	influence	2162:2170	arg1	had					2282:2284	had	2282:2284	had a significant effect on visual color changes	2282:2329	The changes in pH alone did not statistically influence the color coordinates measured at the analyzed ratio; however, variations in pH associated with other factors had a significant effect on visual color changes, and observations were described.
32486501	11	35	dep	influence	2162:2170	arg1	described					2354:2362	described	2354:2362	were described	2349:2362	The changes in pH alone did not statistically influence the color coordinates measured at the analyzed ratio; however, variations in pH associated with other factors had a significant effect on visual color changes, and observations were described.
32486501	4	36	theme	3	941:941	arg1	%					942:942	%	942:942	%	942:942	Cellulose acetate films (3% wt.)
32486501	10	37	theme	optimal	1949:1955	arg1	conditions					1962:1971	The optimal film conditions	1945:1971	The optimal film conditions	1945:1971	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	2	38	theme	biochemical	624:634	arg1	changes					636:642	chemical or biochemical changes	612:642	chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red	612:723	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	8	39	from	factors	1502:1508	arg1	behavior					1517:1524	the behavior	1513:1524	the behavior of PDA's color changing	1513:1548	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	0	40	theme	Cellulose	99:107	arg1	Acetate					109:115	Cellulose Acetate	99:115	Cellulose Acetate Incorporated with Polydiacetylene for an Efficient Packaging	99:176	Development and Evaluation of the Chromatic Behavior of an Intelligent Packaging Material Based on Cellulose Acetate Incorporated with Polydiacetylene for an Efficient Packaging.
32486501	1	41	theme	intelligent	376:386	arg1	packaging					388:396	intelligent packaging	376:396	intelligent packaging	376:396	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	9	42	theme	cellulose	1857:1865	arg1	matrix					1875:1880	the cellulose acetate matrix	1853:1880	the cellulose acetate matrix	1853:1880	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	1	43	theme	safe	276:279	arg1	conditions					281:290	safe conditions	276:290	safe conditions	276:290	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	3	44	dep	acetate-based	855:867	arg1	incorporated					869:880	incorporated	869:880	acetate-based incorporated with PDA as the substance sensor	855:913	This work focused on the development and optimization of an intelligent packaging constituted of a polymeric matrix of cellulose acetate-based incorporated with PDA as the substance sensor.
32486501	12	45	theme	real	2562:2565	arg1	time					2567:2570	real time	2562:2570	real time	2562:2570	PDA films were optimized to maximize color change in order to obtain a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety.
32486501	8	46	theme	pH	1426:1427	arg1	4-11					1437:1440	4-11	1437:1440	4-11	1437:1440	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	8	46	theme	pH	1426:1427	arg1	values					1429:1434	pH values	1426:1434	pH values (4-11)	1426:1441	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	10	47	theme	polymerization	2028:2041	arg1	time					2043:2046	polymerization time	2028:2046	polymerization time of 18 min under UV light	2028:2071	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	10	47	theme	polymerization	2028:2041	arg1	PDA					2008:2010	PDA	2008:2010	PDA	2008:2010	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	3	48	theme	substance	898:906	arg1	sensor					908:913	the substance sensor	894:913	the substance sensor	894:913	This work focused on the development and optimization of an intelligent packaging constituted of a polymeric matrix of cellulose acetate-based incorporated with PDA as the substance sensor.
32486501	2	49	from	red	721:723	arg1	transition					697:706	PDA's color transition	685:706	PDA's color transition from blue to red	685:723	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	2	50	theme	synthetic	457:465	arg1	material					467:474	a synthetic material	455:474	a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red	455:723	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	2	50	theme	synthetic	457:465	arg1	substance					532:540	a sensor substance	523:540	a sensor substance	523:540	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	2	50	theme	synthetic	457:465	arg1	Polydiacetylene					430:444	Polydiacetylene	430:444	Polydiacetylene (PDA)	430:450	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	12	51	theme	food	2587:2590	arg1	control					2600:2606	the food quality control	2583:2606	the food quality control	2583:2606	PDA films were optimized to maximize color change in order to obtain a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety.
32486501	8	52	theme	design	1317:1322	arg1	variables					1324:1332	Three more design variables	1306:1332	Three more design variables	1306:1332	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	0	53	theme	Behavior	44:51	arg1	Evaluation					16:25	Evaluation	16:25	Evaluation	16:25	Development and Evaluation of the Chromatic Behavior of an Intelligent Packaging Material Based on Cellulose Acetate Incorporated with Polydiacetylene for an Efficient Packaging.
32486501	0	53	theme	Behavior	44:51	arg1	Development					0:10	Development	0:10	Development	0:10	Development and Evaluation of the Chromatic Behavior of an Intelligent Packaging Material Based on Cellulose Acetate Incorporated with Polydiacetylene for an Efficient Packaging.
32486501	10	54	theme	100	2077:2079	arg1	°C					2081:2082	°C	2081:2082	°C	2081:2082	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	6	55	theme	of	1050:1051	arg1	mg					1086:1087	0-60 mg	1081:1087	0-60 mg	1081:1087	of cellulose-acetate) and PDA (0-60 mg) were analyzed to optimize the conditions for the best color transitioning at this study range.
32486501	6	55	theme	of	1050:1051	arg1	cellulose-acetate					1053:1069	of cellulose-acetate) and PDA	1050:1078	cellulose-acetate	1053:1069	of cellulose-acetate) and PDA (0-60 mg) were analyzed to optimize the conditions for the best color transitioning at this study range.
32486501	8	56	theme	temperature	1447:1457	arg1	exposure					1459:1466	temperature exposure	1447:1466	temperature exposure	1447:1466	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	8	57	theme	important	1492:1500	arg1	film					1475:1478	the film	1471:1478	the film (0-100 °C)	1471:1489	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	8	57	theme	important	1492:1500	arg1	factors					1502:1508	important factors	1492:1508	important factors on the behavior of PDA's color changing	1492:1548	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	2	58	dep	red	721:723	arg1	to					718:719	to	718:719	to	718:719	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	9	59	theme	PDA	1687:1689	arg1	films					1691:1695	PDA films	1687:1695	PDA films	1687:1695	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	9	60	theme	light	1926:1930	arg1	irradiation					1932:1942	UV light irradiation	1923:1942	UV light irradiation	1923:1942	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	11	61	from	changes	2120:2126	arg1	pH					2131:2132	pH	2131:2132	pH	2131:2132	The changes in pH alone did not statistically influence the color coordinates measured at the analyzed ratio; however, variations in pH associated with other factors had a significant effect on visual color changes, and observations were described.
32486501	1	62	theme	new	233:235	arg1	products					237:244	new products	233:244	new products with natural characteristics, safe conditions and traceability	233:307	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	10	63	theme	temperature	2094:2104	arg1	exposure					2106:2113	temperature exposure	2094:2113	temperature exposure	2094:2113	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	5	64	dep	plasticizer	1021:1031	arg1	wt					1046:1047	0-25% wt	1040:1047	plasticizer (TEC) (0-25% wt	1021:1047	were developed by a casting method, and the amounts of triethyl citrate plasticizer (TEC) (0-25% wt.
32486501	12	65	theme	capable	2497:2503	arg1	packaging					2487:2495	intelligent packaging	2475:2495	intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety	2475:2626	PDA films were optimized to maximize color change in order to obtain a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety.
32486501	12	66	theme	simple	2446:2451	arg1	technology					2453:2462	a cheap and simple technology	2434:2462	a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety	2434:2626	PDA films were optimized to maximize color change in order to obtain a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety.
32486501	10	67	theme	UV	2064:2065	arg1	light					2067:2071	UV light	2064:2071	UV light	2064:2071	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	9	68	theme	pH	1713:1714	arg1	conditions					1732:1741	different pH and temperature conditions	1703:1741	different pH and temperature conditions	1703:1741	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	9	69	theme	PDA	1821:1823	arg1	optimization					1805:1816	the optimization	1801:1816	the optimization of PDA and TEC concentrations into the cellulose acetate matrix	1801:1880	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	10	70	theme	min	2054:2056	arg1	time					2043:2046	polymerization time	2028:2046	polymerization time of 18 min under UV light	2028:2071	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	10	70	theme	min	2054:2056	arg1	PDA					2008:2010	PDA	2008:2010	PDA	2008:2010	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	9	71	theme	temperature	1720:1730	arg1	conditions					1732:1741	different pH and temperature conditions	1703:1741	different pH and temperature conditions	1703:1741	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	1	72	theme	Global	179:184	arg1	growth					186:191	Global growth	179:191	Global growth of the food industry	179:212	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	2	73	theme	chemical	612:619	arg1	changes					636:642	chemical or biochemical changes	612:642	chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red	612:723	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	1	74	theme	food	200:203	arg1	industry					205:212	the food industry	196:212	the food industry	196:212	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	4	75	dep	films	934:938	arg1	wt					944:945	3% wt	941:945	3% wt.	941:946	Cellulose acetate films (3% wt.)
32486501	1	76	theme	capable	399:405	arg1	packaging					388:396	intelligent packaging	376:396	intelligent packaging	376:396	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	2	77	theme	sensor	525:530	arg1	material					467:474	a synthetic material	455:474	a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red	455:723	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	2	77	theme	sensor	525:530	arg1	substance					532:540	a sensor substance	523:540	a sensor substance	523:540	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	8	78	theme	polymerization	1361:1374	arg1	time					1376:1379	the polymerization time	1357:1379	the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing	1357:1548	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	0	79	theme	Efficient	158:166	arg1	Packaging					168:176	an Efficient Packaging	155:176	an Efficient Packaging	155:176	Development and Evaluation of the Chromatic Behavior of an Intelligent Packaging Material Based on Cellulose Acetate Incorporated with Polydiacetylene for an Efficient Packaging.
32486501	11	80	from	variations	2235:2244	arg1	pH					2249:2250	pH	2249:2250	pH associated with other factors	2249:2280	The changes in pH alone did not statistically influence the color coordinates measured at the analyzed ratio; however, variations in pH associated with other factors had a significant effect on visual color changes, and observations were described.
32486501	10	81	theme	TEC	2023:2025	arg1	TEC					2023:2025	TEC	2023:2025	TEC	2023:2025	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	10	81	theme	TEC	2023:2025	arg1	PDA					2008:2010	PDA	2008:2010	PDA	2008:2010	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	10	81	theme	TEC	2023:2025	arg1	%					2018:2018	10%	2016:2018	10% of TEC	2016:2025	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	10	81	theme	TEC	2023:2025	arg1	time					2043:2046	polymerization time	2028:2046	polymerization time of 18 min under UV light	2028:2071	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	9	82	theme	film	1566:1569	arg1	thickness					1571:1579	film thickness	1566:1579	film thickness	1566:1579	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	11	83	theme	significant	2288:2298	arg1	effect					2300:2305	a significant effect	2286:2305	a significant effect	2286:2305	The changes in pH alone did not statistically influence the color coordinates measured at the analyzed ratio; however, variations in pH associated with other factors had a significant effect on visual color changes, and observations were described.
32486501	7	84	theme	Composite	1281:1289	arg1	CCD					1300:1302	CCD	1300:1302	CCD	1300:1302	The compound amounts incorporated into polymeric matrices were established according to Central Composite Designs (CCD).
32486501	7	84	theme	Composite	1281:1289	arg1	Designs					1291:1297	Central Composite Designs	1273:1297	Central Composite Designs (CCD)	1273:1303	The compound amounts incorporated into polymeric matrices were established according to Central Composite Designs (CCD).
32486501	11	85	theme	analyzed	2210:2217	arg1	ratio					2219:2223	the analyzed ratio	2206:2223	the analyzed ratio	2206:2223	The changes in pH alone did not statistically influence the color coordinates measured at the analyzed ratio; however, variations in pH associated with other factors had a significant effect on visual color changes, and observations were described.
32486501	0	86	theme	Intelligent	59:69	arg1	Material					81:88	an Intelligent Packaging Material	56:88	an Intelligent Packaging Material	56:88	Development and Evaluation of the Chromatic Behavior of an Intelligent Packaging Material Based on Cellulose Acetate Incorporated with Polydiacetylene for an Efficient Packaging.
32486501	5	87	theme	triethyl	1004:1011	arg1	triethyl					1004:1011	triethyl	1004:1011	triethyl	1004:1011	were developed by a casting method, and the amounts of triethyl citrate plasticizer (TEC) (0-25% wt.
32486501	5	87	theme	triethyl	1004:1011	arg1	amounts					993:999	the amounts	989:999	the amounts of triethyl	989:1011	were developed by a casting method, and the amounts of triethyl citrate plasticizer (TEC) (0-25% wt.
32486501	4	88	theme	%	942:942	arg1	wt					944:945	3% wt	941:945	3% wt.	941:946	Cellulose acetate films (3% wt.)
32486501	8	89	theme	light	1397:1401	arg1	exposition					1403:1412	UV light exposition	1394:1412	UV light exposition (0-60 min)	1394:1423	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	8	89	theme	light	1397:1401	arg1	min					1420:1422	0-60 min	1415:1422	0-60 min	1415:1422	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	10	90	theme	PDA	2008:2010	arg1	g					2003:2003	50.48 g	1997:2003	50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light,	1997:2072	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	0	91	theme	Material	81:88	arg1	Behavior					44:51	the Chromatic Behavior	30:51	the Chromatic Behavior of an Intelligent Packaging Material	30:88	Development and Evaluation of the Chromatic Behavior of an Intelligent Packaging Material Based on Cellulose Acetate Incorporated with Polydiacetylene for an Efficient Packaging.
32486501	9	92	theme	color	1590:1594	arg1	coordinates					1596:1606	film color coordinates	1585:1606	film color coordinates	1585:1606	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	1	93	theme	technologies	355:366	arg1	development					340:350	the development	336:350	the development of technologies such as intelligent packaging, capable to fulfil those needs	336:427	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	3	94	theme	cellulose	845:853	arg1	matrix					835:840	a polymeric matrix	823:840	a polymeric matrix of cellulose	823:853	This work focused on the development and optimization of an intelligent packaging constituted of a polymeric matrix of cellulose acetate-based incorporated with PDA as the substance sensor.
32486501	4	95	theme	acetate	926:932	arg1	films					934:938	Cellulose acetate films	916:938	Cellulose acetate films (3% wt.)	916:947	Cellulose acetate films (3% wt.)
32486501	9	96	theme	concentrations	1833:1846	arg1	optimization					1805:1816	the optimization	1801:1816	the optimization of PDA and TEC concentrations into the cellulose acetate matrix	1801:1880	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	3	97	theme	intelligent	786:796	arg1	packaging					798:806	an intelligent packaging	783:806	an intelligent packaging constituted of a polymeric matrix of cellulose	783:853	This work focused on the development and optimization of an intelligent packaging constituted of a polymeric matrix of cellulose acetate-based incorporated with PDA as the substance sensor.
32486501	2	98	theme	research	505:512	arg1	field					514:518	research field	505:518	research field	505:518	Polydiacetylene (PDA) is a synthetic material that has been highlighted in research field as a sensor substance, which can be used to produce intelligent packaging capable to detect chemical or biochemical changes in foods and in their environment due to PDA's color transition from blue to red.
32486501	12	99	theme	color	2402:2406	arg1	change					2408:2413	color change	2402:2413	color change	2402:2413	PDA films were optimized to maximize color change in order to obtain a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety.
32486501	5	100	theme	%	1044:1044	arg1	wt					1046:1047	0-25% wt	1040:1047	plasticizer (TEC) (0-25% wt	1021:1047	were developed by a casting method, and the amounts of triethyl citrate plasticizer (TEC) (0-25% wt.
32486501	9	101	gly	homogeneity	1644:1654	arg1	films					1691:1695	PDA films	1687:1695	PDA films	1687:1695	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	7	102	theme	polymeric	1224:1232	arg1	matrices					1234:1241	polymeric matrices	1224:1241	polymeric matrices	1224:1241	The compound amounts incorporated into polymeric matrices were established according to Central Composite Designs (CCD).
32486501	12	103	theme	distribution	2540:2551	arg1	chain					2553:2557	the distribution chain	2536:2557	the distribution chain	2536:2557	PDA films were optimized to maximize color change in order to obtain a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety.
32486501	9	104	theme	acetate	1867:1873	arg1	matrix					1875:1880	the cellulose acetate matrix	1853:1880	the cellulose acetate matrix	1853:1880	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	10	105	theme	%	2018:2018	arg1	g					2003:2003	50.48 g	1997:2003	50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light,	1997:2072	The optimal film conditions were obtained by adding 50.48 g of PDA and 10% of TEC, polymerization time of 18 min under UV light, at 100 °C ± 2 °C of temperature exposure.
32486501	0	106	theme	Chromatic	34:42	arg1	Behavior					44:51	the Chromatic Behavior	30:51	the Chromatic Behavior of an Intelligent Packaging Material	30:88	Development and Evaluation of the Chromatic Behavior of an Intelligent Packaging Material Based on Cellulose Acetate Incorporated with Polydiacetylene for an Efficient Packaging.
32486501	5	107	theme	casting	969:975	arg1	method					977:982	a casting method	967:982	a casting method	967:982	were developed by a casting method, and the amounts of triethyl citrate plasticizer (TEC) (0-25% wt.
32486501	7	108	theme	compound	1189:1196	arg1	amounts					1198:1204	The compound amounts	1185:1204	The compound amounts incorporated into polymeric matrices	1185:1241	The compound amounts incorporated into polymeric matrices were established according to Central Composite Designs (CCD).
32486501	12	109	theme	food	2516:2519	arg1	products					2521:2528	food products	2516:2528	food products along the distribution chain	2516:2557	PDA films were optimized to maximize color change in order to obtain a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety.
32486501	9	110	theme	polymerization	1890:1903	arg1	degree					1905:1910	the polymerization degree	1886:1910	the polymerization degree trigged by UV light irradiation	1886:1942	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	8	111	from	time	1376:1379	arg1	film					1475:1478	the film	1471:1478	the film (0-100 °C)	1471:1489	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	8	111	from	time	1376:1379	arg1	°C					1487:1488	0-100 °C	1481:1488	0-100 °C	1481:1488	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	8	111	from	time	1376:1379	arg1	factors					1502:1508	important factors	1492:1508	important factors on the behavior of PDA's color changing	1492:1548	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	1	112	theme	driven	314:319	arg1	researches					321:330	driven researches	314:330	driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs	314:427	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	5	113	theme	0-25	1040:1043	arg1	%					1044:1044	%	1044:1044	%	1044:1044	were developed by a casting method, and the amounts of triethyl citrate plasticizer (TEC) (0-25% wt.
32486501	9	114	theme	color	1664:1668	arg1	transitioning					1670:1682	the color transitioning	1660:1682	the color transitioning of PDA films	1660:1695	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	11	115	theme	other	2268:2272	arg1	factors					2274:2280	other factors	2268:2280	other factors	2268:2280	The changes in pH alone did not statistically influence the color coordinates measured at the analyzed ratio; however, variations in pH associated with other factors had a significant effect on visual color changes, and observations were described.
32486501	8	116	dep	such	1349:1352	arg1	as					1354:1355	as	1354:1355	as	1354:1355	Three more design variables were analyzed, such as the polymerization time of PDA under UV light exposition (0-60 min), pH values (4-11) and temperature exposure on the film (0-100 °C), important factors on the behavior of PDA's color changing.
32486501	9	117	theme	UV	1923:1924	arg1	irradiation					1932:1942	UV light irradiation	1923:1942	UV light irradiation	1923:1942	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	1	118	with	products	237:244	arg1	traceability					296:307	traceability	296:307	traceability	296:307	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	1	118	with	products	237:244	arg1	characteristics					259:273	natural characteristics	251:273	natural characteristics	251:273	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	1	118	with	products	237:244	arg1	conditions					281:290	safe conditions	276:290	safe conditions	276:290	Global growth of the food industry and the demand for new products with natural characteristics, safe conditions and traceability have driven researches for the development of technologies such as intelligent packaging, capable to fulfil those needs.
32486501	9	119	theme	films	1691:1695	arg1	transitioning					1670:1682	the color transitioning	1660:1682	the color transitioning of PDA films	1660:1695	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	9	119	theme	films	1691:1695	arg1	homogeneity					1644:1654	the homogeneity	1640:1654	the homogeneity	1640:1654	In this study, film thickness and film color coordinates were measured in order to study the homogeneity and the color transitioning of PDA films under different pH and temperature conditions, with the purpose of maximizing the color changes through the optimization of PDA and TEC concentrations into the cellulose acetate matrix and the polymerization degree trigged by UV light irradiation.
32486501	11	120	theme	color	2317:2321	arg1	changes					2323:2329	visual color changes	2310:2329	visual color changes	2310:2329	The changes in pH alone did not statistically influence the color coordinates measured at the analyzed ratio; however, variations in pH associated with other factors had a significant effect on visual color changes, and observations were described.
32486501	12	121	theme	consumer	2612:2619	arg1	safety					2621:2626	consumer safety	2612:2626	consumer safety	2612:2626	PDA films were optimized to maximize color change in order to obtain a cheap and simple technology to produce intelligent packaging capable to monitor food products along the distribution chain in real time, improving the food quality control and consumer safety.
32574736	11	0	theme	novel	1448:1452	arg1	knowledge					1454:1462	novel knowledge	1448:1462	novel knowledge on the NSG, which will be inestimable for clarifying its matchless functional properties	1448:1551	In conclusion, the present study supplied novel knowledge on the NSG, which will be inestimable for clarifying its matchless functional properties.
32574736	3	1	theme	gum	448:450	arg1	information					429:439	the structural information	414:439	the structural information of the gum	414:450	In order to clarify the structural information of the gum, the FT-IR analysis and monosaccharide composition determination were performed.
32574736	8	2	theme	Intrinsic	948:956	arg1	viscosity					958:966	Intrinsic viscosity	948:966	Intrinsic viscosity	948:966	Intrinsic viscosity, average viscosity and molecular weight values were determined as 8.56 ± 0.4 dL/g and 1.89 ± 0.1 × 106 g/mol, respectively.
32574736	6	3	theme	Mannose/Galactose	789:805	arg1	1.07					831:834	1.07	831:834	1.07	831:834	Furthermore, Mannose/Galactose ratio was calculated as 1.07, indicating the water solubility of gum.
32574736	6	3	theme	Mannose/Galactose	789:805	arg1	ratio					807:811	Mannose/Galactose ratio	789:811	Mannose/Galactose ratio	789:811	Furthermore, Mannose/Galactose ratio was calculated as 1.07, indicating the water solubility of gum.
32574736	10	4	theme	viscoelastic	1314:1325	arg1	properties					1327:1336	viscoelastic properties	1314:1336	viscoelastic properties	1314:1336	The NSG exhibited shear thinning behavior while dynamic rheological analysis indicated the NSG had viscoelastic properties and G' (the storage modulus) was higher than G″ (the loss modulus).
32574736	10	5	theme	dynamic	1263:1269	arg1	analysis					1283:1290	dynamic rheological analysis	1263:1290	dynamic rheological analysis	1263:1290	The NSG exhibited shear thinning behavior while dynamic rheological analysis indicated the NSG had viscoelastic properties and G' (the storage modulus) was higher than G″ (the loss modulus).
32574736	4	6	theme	total	601:605	arg1	protein					607:613	total protein	601:613	2.89% total protein	595:613	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	1	7	theme	yield	212:216	arg1	terms					203:207	terms	203:207	terms of yield, physicochemical, rheological, functional and thermal properties	203:281	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	3	8	theme	monosaccharide	476:489	arg1	composition					491:501	monosaccharide composition	476:501	monosaccharide composition	476:501	In order to clarify the structural information of the gum, the FT-IR analysis and monosaccharide composition determination were performed.
32574736	9	9	dep	capacity	1111:1118	arg1	The					1092:1094	The	1092:1094	The	1092:1094	The emulsification capacity, emulsion stability and foam formation capacity of the NSG were 48%, 40% and 4%, respectively.
32574736	6	10	theme	gum	872:874	arg1	solubility					858:867	the water solubility	848:867	the water solubility of gum	848:874	Furthermore, Mannose/Galactose ratio was calculated as 1.07, indicating the water solubility of gum.
32574736	4	11	theme	total	643:647	arg1	carbohydrate					649:660	total carbohydrate	643:660	76.67% total carbohydrate	636:660	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	3	12	theme	composition	491:501	arg1	determination					503:515	the FT-IR analysis and monosaccharide composition determination	453:515	the FT-IR analysis and monosaccharide composition determination	453:515	In order to clarify the structural information of the gum, the FT-IR analysis and monosaccharide composition determination were performed.
32574736	5	13	theme	binding	767:773	arg1	capability					749:758	the capability	745:758	the capability of ion binding	745:773	The FT-IR analysis revealed the existence of carboxyl groups, which gives the gum the capability of ion binding.
32574736	1	14	theme	physicochemical	219:233	arg1	yield					212:216	yield	212:216	yield	212:216	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	1	14	theme	physicochemical	219:233	arg1	properties					272:281	physicochemical, rheological, functional and thermal properties	219:281	physicochemical, rheological, functional and thermal properties	219:281	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	4	15	dep	%	641:641	arg1	carbohydrate					649:660	total carbohydrate	643:660	76.67% total carbohydrate	636:660	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	10	16	theme	thinning	1239:1246	arg1	behavior					1248:1255	shear thinning behavior	1233:1255	shear thinning behavior	1233:1255	The NSG exhibited shear thinning behavior while dynamic rheological analysis indicated the NSG had viscoelastic properties and G' (the storage modulus) was higher than G″ (the loss modulus).
32574736	3	17	theme	analysis	463:470	arg1	determination					503:515	the FT-IR analysis and monosaccharide composition determination	453:515	the FT-IR analysis and monosaccharide composition determination	453:515	In order to clarify the structural information of the gum, the FT-IR analysis and monosaccharide composition determination were performed.
32574736	11	18	from	knowledge	1454:1462	arg1	inestimable					1490:1500	inestimable	1490:1500	inestimable	1490:1500	In conclusion, the present study supplied novel knowledge on the NSG, which will be inestimable for clarifying its matchless functional properties.
32574736	11	18	from	knowledge	1454:1462	arg1	NSG					1471:1473	the NSG	1467:1473	the NSG	1467:1473	In conclusion, the present study supplied novel knowledge on the NSG, which will be inestimable for clarifying its matchless functional properties.
32574736	4	19	theme	total	584:588	arg1	ash					590:592	total ash	584:592	10.81% total ash	577:592	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	5	20	theme	FT-IR	667:671	arg1	analysis					673:680	The FT-IR analysis	663:680	The FT-IR analysis	663:680	The FT-IR analysis revealed the existence of carboxyl groups, which gives the gum the capability of ion binding.
32574736	9	21	theme	emulsification	1096:1109	arg1	capacity					1111:1118	emulsification capacity	1096:1118	emulsification capacity	1096:1118	The emulsification capacity, emulsion stability and foam formation capacity of the NSG were 48%, 40% and 4%, respectively.
32574736	0	22	dep	seeds	68:72	arg1	dioica					60:65	Urtica dioica	53:65	Urtica dioica	53:65	Extraction of a novel water-soluble gum from nettle (Urtica dioica) seeds: Optimization and characterization.
32574736	11	23	theme	matchless	1521:1529	arg1	properties					1542:1551	its matchless functional properties	1517:1551	its matchless functional properties	1517:1551	In conclusion, the present study supplied novel knowledge on the NSG, which will be inestimable for clarifying its matchless functional properties.
32574736	10	24	theme	storage	1350:1356	arg1	modulus					1358:1364	the storage modulus	1346:1364	the storage modulus	1346:1364	The NSG exhibited shear thinning behavior while dynamic rheological analysis indicated the NSG had viscoelastic properties and G' (the storage modulus) was higher than G″ (the loss modulus).
32574736	10	24	theme	storage	1350:1356	arg1	G					1342:1342	G'	1342:1343	G' (the storage modulus)	1342:1365	The NSG exhibited shear thinning behavior while dynamic rheological analysis indicated the NSG had viscoelastic properties and G' (the storage modulus) was higher than G″ (the loss modulus).
32574736	10	25	theme	rheological	1271:1281	arg1	analysis					1283:1290	dynamic rheological analysis	1263:1290	dynamic rheological analysis	1263:1290	The NSG exhibited shear thinning behavior while dynamic rheological analysis indicated the NSG had viscoelastic properties and G' (the storage modulus) was higher than G″ (the loss modulus).
32574736	9	26	theme	NSG	1175:1177	arg1	capacity					1111:1118	emulsification capacity	1096:1118	emulsification capacity	1096:1118	The emulsification capacity, emulsion stability and foam formation capacity of the NSG were 48%, 40% and 4%, respectively.
32574736	9	26	theme	NSG	1175:1177	arg1	stability					1130:1138	emulsion stability	1121:1138	emulsion stability	1121:1138	The emulsification capacity, emulsion stability and foam formation capacity of the NSG were 48%, 40% and 4%, respectively.
32574736	9	26	theme	NSG	1175:1177	arg1	capacity					1159:1166	foam formation capacity	1144:1166	foam formation capacity	1144:1166	The emulsification capacity, emulsion stability and foam formation capacity of the NSG were 48%, 40% and 4%, respectively.
32574736	4	27	dep	%	620:620	arg1	oil					628:630	total oil	622:630	1.15% total oil	616:630	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	2	28	theme	extraction	339:348	arg1	%					378:378	6.17%	374:378	6.17%	374:378	According to Response Surface Methodology, the maximum extraction yield was determined as 6.17% on dry basis.
32574736	2	28	theme	extraction	339:348	arg1	yield					350:354	the maximum extraction yield	327:354	the maximum extraction yield	327:354	According to Response Surface Methodology, the maximum extraction yield was determined as 6.17% on dry basis.
32574736	0	29	theme	novel	16:20	arg1	gum					36:38	a novel water-soluble gum	14:38	a novel water-soluble gum	14:38	Extraction of a novel water-soluble gum from nettle (Urtica dioica) seeds: Optimization and characterization.
32574736	1	30	theme	rheological	236:246	arg1	yield					212:216	yield	212:216	yield	212:216	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	1	30	theme	rheological	236:246	arg1	properties					272:281	physicochemical, rheological, functional and thermal properties	219:281	physicochemical, rheological, functional and thermal properties	219:281	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	8	31	theme	viscosity	958:966	arg1	dL/g					1045:1048	8.56 ± 0.4 dL/g	1034:1048	8.56 ± 0.4 dL/g	1034:1048	Intrinsic viscosity, average viscosity and molecular weight values were determined as 8.56 ± 0.4 dL/g and 1.89 ± 0.1 × 106 g/mol, respectively.
32574736	8	31	theme	viscosity	958:966	arg1	values					1008:1013	Intrinsic viscosity, average viscosity and molecular weight values	948:1013	Intrinsic viscosity, average viscosity and molecular weight values	948:1013	Intrinsic viscosity, average viscosity and molecular weight values were determined as 8.56 ± 0.4 dL/g and 1.89 ± 0.1 × 106 g/mol, respectively.
32574736	8	31	theme	viscosity	958:966	arg1	1.89 ± 0.1 × 106 g/mol					1054:1075	1.89 ± 0.1 × 106 g/mol	1054:1075	1.89 ± 0.1 × 106 g/mol	1054:1075	Intrinsic viscosity, average viscosity and molecular weight values were determined as 8.56 ± 0.4 dL/g and 1.89 ± 0.1 × 106 g/mol, respectively.
32574736	9	32	theme	emulsion	1121:1128	arg1	stability					1130:1138	emulsion stability	1121:1138	emulsion stability	1121:1138	The emulsification capacity, emulsion stability and foam formation capacity of the NSG were 48%, 40% and 4%, respectively.
32574736	1	33	theme	potential	149:157	arg1	source					159:164	a novel potential source	141:164	a novel potential source of hydrocolloid	141:180	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	1	33	theme	potential	149:157	arg1	gum					122:124	Nettle seed gum	110:124	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid	110:180	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	2	34	theme	dry	383:385	arg1	basis					387:391	dry basis	383:391	dry basis	383:391	According to Response Surface Methodology, the maximum extraction yield was determined as 6.17% on dry basis.
32574736	4	35	dep	%	599:599	arg1	protein					607:613	total protein	601:613	2.89% total protein	595:613	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	9	36	theme	formation	1149:1157	arg1	capacity					1159:1166	foam formation capacity	1144:1166	foam formation capacity	1144:1166	The emulsification capacity, emulsion stability and foam formation capacity of the NSG were 48%, 40% and 4%, respectively.
32574736	10	37	theme	loss	1391:1394	arg1	modulus					1396:1402	the loss modulus	1387:1402	the loss modulus	1387:1402	The NSG exhibited shear thinning behavior while dynamic rheological analysis indicated the NSG had viscoelastic properties and G' (the storage modulus) was higher than G″ (the loss modulus).
32574736	10	37	theme	loss	1391:1394	arg1	G″					1383:1384	G″	1383:1384	G″ (the loss modulus)	1383:1403	The NSG exhibited shear thinning behavior while dynamic rheological analysis indicated the NSG had viscoelastic properties and G' (the storage modulus) was higher than G″ (the loss modulus).
32574736	5	38	theme	ion	763:765	arg1	binding					767:773	ion binding	763:773	ion binding	763:773	The FT-IR analysis revealed the existence of carboxyl groups, which gives the gum the capability of ion binding.
32574736	0	39	theme	gum	36:38	arg1	Extraction					0:9	Extraction	0:9	Extraction of a novel water-soluble gum from nettle (Urtica dioica) seeds: Optimization and characterization.	0:108	Extraction of a novel water-soluble gum from nettle (Urtica dioica) seeds: Optimization and characterization.
32574736	1	40	theme	functional	249:258	arg1	yield					212:216	yield	212:216	yield	212:216	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	1	40	theme	functional	249:258	arg1	properties					272:281	physicochemical, rheological, functional and thermal properties	219:281	physicochemical, rheological, functional and thermal properties	219:281	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	8	41	theme	average	969:975	arg1	viscosity					977:985	average viscosity	969:985	average viscosity	969:985	Intrinsic viscosity, average viscosity and molecular weight values were determined as 8.56 ± 0.4 dL/g and 1.89 ± 0.1 × 106 g/mol, respectively.
32574736	11	42	theme	functional	1531:1540	arg1	properties					1542:1551	its matchless functional properties	1517:1551	its matchless functional properties	1517:1551	In conclusion, the present study supplied novel knowledge on the NSG, which will be inestimable for clarifying its matchless functional properties.
32574736	1	43	theme	novel	143:147	arg1	source					159:164	a novel potential source	141:164	a novel potential source of hydrocolloid	141:180	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	1	43	theme	novel	143:147	arg1	gum					122:124	Nettle seed gum	110:124	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid	110:180	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	0	44	theme	water-soluble	22:34	arg1	gum					36:38	a novel water-soluble gum	14:38	a novel water-soluble gum	14:38	Extraction of a novel water-soluble gum from nettle (Urtica dioica) seeds: Optimization and characterization.
32574736	7	45	theme	thermal	931:937	arg1	process					939:945	thermal process	931:945	thermal process	931:945	DSC analysis showed that the NSG was highly stable in thermal process.
32574736	9	46	theme	foam	1144:1147	arg1	formation					1149:1157	foam formation	1144:1157	foam formation capacity	1144:1166	The emulsification capacity, emulsion stability and foam formation capacity of the NSG were 48%, 40% and 4%, respectively.
32574736	5	47	theme	carboxyl	708:715	arg1	groups					717:722	carboxyl groups	708:722	carboxyl groups	708:722	The FT-IR analysis revealed the existence of carboxyl groups, which gives the gum the capability of ion binding.
32574736	11	48	theme	present	1425:1431	arg1	study					1433:1437	the present study	1421:1437	the present study	1421:1437	In conclusion, the present study supplied novel knowledge on the NSG, which will be inestimable for clarifying its matchless functional properties.
32574736	1	49	theme	hydrocolloid	169:180	arg1	source					159:164	a novel potential source	141:164	a novel potential source of hydrocolloid	141:180	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	1	49	theme	hydrocolloid	169:180	arg1	gum					122:124	Nettle seed gum	110:124	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid	110:180	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	0	50	theme	nettle	45:50	arg1	seeds					68:72	nettle (Urtica dioica) seeds	45:72	nettle (Urtica dioica) seeds	45:72	Extraction of a novel water-soluble gum from nettle (Urtica dioica) seeds: Optimization and characterization.
32574736	1	51	theme	thermal	264:270	arg1	yield					212:216	yield	212:216	yield	212:216	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	1	51	theme	thermal	264:270	arg1	properties					272:281	physicochemical, rheological, functional and thermal properties	219:281	physicochemical, rheological, functional and thermal properties	219:281	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	5	52	theme	groups	717:722	arg1	existence					695:703	the existence	691:703	the existence	691:703	The FT-IR analysis revealed the existence of carboxyl groups, which gives the gum the capability of ion binding.
32574736	6	53	theme	water	852:856	arg1	solubility					858:867	the water solubility	848:867	the water solubility of gum	848:874	Furthermore, Mannose/Galactose ratio was calculated as 1.07, indicating the water solubility of gum.
32574736	2	54	theme	Surface	306:312	arg1	Methodology					314:324	Response Surface Methodology	297:324	Response Surface Methodology	297:324	According to Response Surface Methodology, the maximum extraction yield was determined as 6.17% on dry basis.
32574736	8	55	theme	viscosity	977:985	arg1	dL/g					1045:1048	8.56 ± 0.4 dL/g	1034:1048	8.56 ± 0.4 dL/g	1034:1048	Intrinsic viscosity, average viscosity and molecular weight values were determined as 8.56 ± 0.4 dL/g and 1.89 ± 0.1 × 106 g/mol, respectively.
32574736	8	55	theme	viscosity	977:985	arg1	values					1008:1013	Intrinsic viscosity, average viscosity and molecular weight values	948:1013	Intrinsic viscosity, average viscosity and molecular weight values	948:1013	Intrinsic viscosity, average viscosity and molecular weight values were determined as 8.56 ± 0.4 dL/g and 1.89 ± 0.1 × 106 g/mol, respectively.
32574736	8	55	theme	viscosity	977:985	arg1	1.89 ± 0.1 × 106 g/mol					1054:1075	1.89 ± 0.1 × 106 g/mol	1054:1075	1.89 ± 0.1 × 106 g/mol	1054:1075	Intrinsic viscosity, average viscosity and molecular weight values were determined as 8.56 ± 0.4 dL/g and 1.89 ± 0.1 × 106 g/mol, respectively.
32574736	4	56	dep	%	565:565	arg1	moisture					567:574	moisture	567:574	8.48% moisture	561:574	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	2	57	theme	Response	297:304	arg1	Methodology					314:324	Response Surface Methodology	297:324	Response Surface Methodology	297:324	According to Response Surface Methodology, the maximum extraction yield was determined as 6.17% on dry basis.
32574736	4	58	dep	%	582:582	arg1	ash					590:592	total ash	584:592	10.81% total ash	577:592	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	8	59	theme	weight	1001:1006	arg1	dL/g					1045:1048	8.56 ± 0.4 dL/g	1034:1048	8.56 ± 0.4 dL/g	1034:1048	Intrinsic viscosity, average viscosity and molecular weight values were determined as 8.56 ± 0.4 dL/g and 1.89 ± 0.1 × 106 g/mol, respectively.
32574736	8	59	theme	weight	1001:1006	arg1	values					1008:1013	Intrinsic viscosity, average viscosity and molecular weight values	948:1013	Intrinsic viscosity, average viscosity and molecular weight values	948:1013	Intrinsic viscosity, average viscosity and molecular weight values were determined as 8.56 ± 0.4 dL/g and 1.89 ± 0.1 × 106 g/mol, respectively.
32574736	8	59	theme	weight	1001:1006	arg1	1.89 ± 0.1 × 106 g/mol					1054:1075	1.89 ± 0.1 × 106 g/mol	1054:1075	1.89 ± 0.1 × 106 g/mol	1054:1075	Intrinsic viscosity, average viscosity and molecular weight values were determined as 8.56 ± 0.4 dL/g and 1.89 ± 0.1 × 106 g/mol, respectively.
32574736	4	60	contain	had	557:559	arg2	%					582:582	10.81%	577:582	10.81% total ash	577:592	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	4	60	contain	had	557:559	arg2	%					641:641	76.67%	636:641	76.67% total carbohydrate	636:660	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	4	60	contain	had	557:559	arg1	NSG					553:555	the NSG	549:555	the NSG	549:555	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	4	60	contain	had	557:559	arg2	%					620:620	1.15%	616:620	1.15% total oil	616:630	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	4	60	contain	had	557:559	arg2	%					565:565	8.48%	561:565	8.48% moisture	561:574	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	4	60	contain	had	557:559	arg2	%					599:599	2.89%	595:599	2.89% total protein	595:613	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	1	61	theme	Nettle	110:115	arg1	source					159:164	a novel potential source	141:164	a novel potential source of hydrocolloid	141:180	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	1	61	theme	Nettle	110:115	arg1	NSG					127:129	NSG	127:129	NSG	127:129	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	1	61	theme	Nettle	110:115	arg1	gum					122:124	Nettle seed gum	110:124	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid	110:180	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	8	62	theme	molecular	991:999	arg1	weight					1001:1006	molecular weight	991:1006	molecular weight	991:1006	Intrinsic viscosity, average viscosity and molecular weight values were determined as 8.56 ± 0.4 dL/g and 1.89 ± 0.1 × 106 g/mol, respectively.
32574736	4	63	theme	total	622:626	arg1	oil					628:630	total oil	622:630	1.15% total oil	616:630	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	10	64	theme	shear	1233:1237	arg1	behavior					1248:1255	shear thinning behavior	1233:1255	shear thinning behavior	1233:1255	The NSG exhibited shear thinning behavior while dynamic rheological analysis indicated the NSG had viscoelastic properties and G' (the storage modulus) was higher than G″ (the loss modulus).
32574736	1	65	theme	seed	117:120	arg1	source					159:164	a novel potential source	141:164	a novel potential source of hydrocolloid	141:180	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	1	65	theme	seed	117:120	arg1	NSG					127:129	NSG	127:129	NSG	127:129	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	1	65	theme	seed	117:120	arg1	gum					122:124	Nettle seed gum	110:124	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid	110:180	Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties.
32574736	3	66	theme	structural	418:427	arg1	information					429:439	the structural information	414:439	the structural information of the gum	414:450	In order to clarify the structural information of the gum, the FT-IR analysis and monosaccharide composition determination were performed.
32574736	0	67	from	seeds	68:72	arg1	Extraction					0:9	Extraction	0:9	Extraction of a novel water-soluble gum from nettle (Urtica dioica) seeds: Optimization and characterization.	0:108	Extraction of a novel water-soluble gum from nettle (Urtica dioica) seeds: Optimization and characterization.
32574736	7	68	theme	DSC	877:879	arg1	analysis					881:888	DSC analysis	877:888	DSC analysis	877:888	DSC analysis showed that the NSG was highly stable in thermal process.
32574736	2	69	theme	maximum	331:337	arg1	%					378:378	6.17%	374:378	6.17%	374:378	According to Response Surface Methodology, the maximum extraction yield was determined as 6.17% on dry basis.
32574736	2	69	theme	maximum	331:337	arg1	yield					350:354	the maximum extraction yield	327:354	the maximum extraction yield	327:354	According to Response Surface Methodology, the maximum extraction yield was determined as 6.17% on dry basis.
32574736	10	70	dep	indicated	1292:1300	arg1	had					1310:1312	had	1310:1312	indicated the NSG had viscoelastic properties	1292:1336	The NSG exhibited shear thinning behavior while dynamic rheological analysis indicated the NSG had viscoelastic properties and G' (the storage modulus) was higher than G″ (the loss modulus).
32574736	4	71	theme	8.48	561:564	arg1	%					565:565	8.48%	561:565	8.48% moisture	561:574	In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate.
32574736	7	72	from	process	939:945	arg1	NSG					906:908	the NSG	902:908	the NSG	902:908	DSC analysis showed that the NSG was highly stable in thermal process.
32574736	7	72	from	process	939:945	arg1	stable					921:926	stable	921:926	stable	921:926	DSC analysis showed that the NSG was highly stable in thermal process.
32574736	0	73	dep	Extraction	0:9	arg1	characterization					92:107	characterization	92:107	characterization	92:107	Extraction of a novel water-soluble gum from nettle (Urtica dioica) seeds: Optimization and characterization.
32574736	0	73	dep	Extraction	0:9	arg1	Optimization					75:86	Optimization	75:86	Optimization	75:86	Extraction of a novel water-soluble gum from nettle (Urtica dioica) seeds: Optimization and characterization.
32574736	3	74	theme	FT-IR	457:461	arg1	analysis					463:470	FT-IR analysis	457:470	FT-IR analysis	457:470	In order to clarify the structural information of the gum, the FT-IR analysis and monosaccharide composition determination were performed.
32574736	7	75	from	stable	921:926	arg1	process					939:945	thermal process	931:945	thermal process	931:945	DSC analysis showed that the NSG was highly stable in thermal process.
34864183	0	0	theme	cell	88:91	arg1	factories					93:101	non-engineered cell factories	73:101	non-engineered cell factories	73:101	Consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered cell factories.
34864183	0	1	theme	non-engineered	73:86	arg1	factories					93:101	non-engineered cell factories	73:101	non-engineered cell factories	73:101	Consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered cell factories.
34864183	6	2	theme	freeze-dried	926:937	arg1	CF2b					939:942	freeze-dried CF2b	926:942	freeze-dried CF2b	926:942	The wet CF1d resulted in 96% of the theoretical ethanol yield while the wet CF1b and freeze-dried CF2b resulted in 89% of the theoretical lactic acid yield.
34864183	7	3	theme	better	1046:1051	arg1	results					1053:1059	better results	1046:1059	better results	1046:1059	The repeated batches using the CF2a-c exhibited better results than using CF1a-c.
34864183	6	4	theme	theoretical	877:887	arg1	yield					897:901	the theoretical ethanol yield	873:901	the theoretical ethanol yield	873:901	The wet CF1d resulted in 96% of the theoretical ethanol yield while the wet CF1b and freeze-dried CF2b resulted in 89% of the theoretical lactic acid yield.
34864183	4	5	theme	lactose	697:703	arg1	SSF					689:691	SSF	689:691	SSF	689:691	S. cerevisiae/SG-β-galactosidase (CF1d) was also used for simultaneous saccharification and fermentation (SSF) of lactose.
34864183	4	5	theme	lactose	697:703	arg1	fermentation					675:686	fermentation	675:686	fermentation (SSF)	675:692	S. cerevisiae/SG-β-galactosidase (CF1d) was also used for simultaneous saccharification and fermentation (SSF) of lactose.
34864183	4	5	theme	lactose	697:703	arg1	saccharification					654:669	simultaneous saccharification	641:669	simultaneous saccharification	641:669	S. cerevisiae/SG-β-galactosidase (CF1d) was also used for simultaneous saccharification and fermentation (SSF) of lactose.
34864183	2	6	theme	different	258:266	arg1	types					268:272	two different types	254:272	two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG)	254:402	Therefore, two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG) were prepared for 5% w/v lactose fermentation.
34864183	8	7	theme	whey	1192:1195	arg1	exploitation					1176:1187	future exploitation	1169:1187	future exploitation of whey	1169:1195	Subsequently, the freeze-dried CF2 as preservative and more manageable were verified for future exploitation of whey.
34864183	1	8	theme	lactose	163:169	arg1	bioprocessing					146:158	the consolidated bioprocessing	129:158	the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs)	129:240	The aim of this study is the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs).
34864183	1	8	theme	lactose	163:169	arg1	aim					108:110	The aim	104:110	The aim of this study	104:124	The aim of this study is the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs).
34864183	8	9	theme	freeze-dried	1098:1109	arg1	CF2					1111:1113	the freeze-dried CF2	1094:1113	the freeze-dried CF2 as preservative and more manageable	1094:1149	Subsequently, the freeze-dried CF2 as preservative and more manageable were verified for future exploitation of whey.
34864183	6	10	theme	wet	845:847	arg1	CF1d					849:852	The wet CF1d	841:852	The wet CF1d	841:852	The wet CF1d resulted in 96% of the theoretical ethanol yield while the wet CF1b and freeze-dried CF2b resulted in 89% of the theoretical lactic acid yield.
34864183	7	11	theme	repeated	1002:1009	arg1	batches					1011:1017	The repeated batches	998:1017	The repeated batches using the CF2a-c	998:1034	The repeated batches using the CF2a-c exhibited better results than using CF1a-c.
34864183	3	12	dep	Kluyveromyces	551:563	arg1	marxianus					565:573	Kluyveromyces marxianus CF1a-c	551:580	Kluyveromyces marxianus CF1a-c	551:580	In CF1, S. cerevisiae was covered with SG containing Lactobacillus casei, Lactobacillus bulgaricus, Kluyveromyces marxianus CF1a-c.
34864183	3	12	dep	Kluyveromyces	551:563	arg1	CF1a-c					575:580	CF1a-c	575:580	Kluyveromyces marxianus CF1a-c	551:580	In CF1, S. cerevisiae was covered with SG containing Lactobacillus casei, Lactobacillus bulgaricus, Kluyveromyces marxianus CF1a-c.
34864183	2	13	theme	5	422:422	arg1	%					423:423	%	423:423	%	423:423	Therefore, two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG) were prepared for 5% w/v lactose fermentation.
34864183	5	14	theme	tubular	743:749	arg1	TC					762:763	TC	762:763	TC	762:763	In CF2, S. cerevisiae immobilized on tubular cellulose (TC) was covered with SG containing the aforementioned microorganisms (CF2a-c).
34864183	5	14	theme	tubular	743:749	arg1	cellulose					751:759	tubular cellulose	743:759	tubular cellulose (TC)	743:764	In CF2, S. cerevisiae immobilized on tubular cellulose (TC) was covered with SG containing the aforementioned microorganisms (CF2a-c).
34864183	1	15	theme	lactic	176:181	arg1	acid					183:186	lactic acid	176:186	lactic acid	176:186	The aim of this study is the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs).
34864183	4	16	theme	simultaneous	641:652	arg1	saccharification					654:669	simultaneous saccharification	641:669	simultaneous saccharification	641:669	S. cerevisiae/SG-β-galactosidase (CF1d) was also used for simultaneous saccharification and fermentation (SSF) of lactose.
34864183	0	17	theme	lactose	30:36	arg1	bioprocessing					13:25	bioprocessing	13:25	bioprocessing of lactose into lactic acid and ethanol	13:65	Consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered cell factories.
34864183	6	18	theme	wet	913:915	arg1	CF1b					917:920	the wet CF1b	909:920	the wet CF1b	909:920	The wet CF1d resulted in 96% of the theoretical ethanol yield while the wet CF1b and freeze-dried CF2b resulted in 89% of the theoretical lactic acid yield.
34864183	5	19	contain	containing	786:795	arg2	CF2a-c					832:837	CF2a-c	832:837	CF2a-c	832:837	In CF2, S. cerevisiae immobilized on tubular cellulose (TC) was covered with SG containing the aforementioned microorganisms (CF2a-c).
34864183	5	19	contain	containing	786:795	arg2	microorganisms					816:829	the aforementioned microorganisms	797:829	the aforementioned microorganisms (CF2a-c)	797:838	In CF2, S. cerevisiae immobilized on tubular cellulose (TC) was covered with SG containing the aforementioned microorganisms (CF2a-c).
34864183	5	19	contain	containing	786:795	arg1	SG					783:784	SG	783:784	SG containing the aforementioned microorganisms (CF2a-c)	783:838	In CF2, S. cerevisiae immobilized on tubular cellulose (TC) was covered with SG containing the aforementioned microorganisms (CF2a-c).
34864183	2	20	theme	biocatalysts	287:298	arg1	types					268:272	two different types	254:272	two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG)	254:402	Therefore, two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG) were prepared for 5% w/v lactose fermentation.
34864183	6	21	theme	acid	986:989	arg1	yield					991:995	the theoretical lactic acid yield	963:995	the theoretical lactic acid yield	963:995	The wet CF1d resulted in 96% of the theoretical ethanol yield while the wet CF1b and freeze-dried CF2b resulted in 89% of the theoretical lactic acid yield.
34864183	4	22	theme	S.	583:584	arg1	CF1d					617:620	CF1d	617:620	CF1d	617:620	S. cerevisiae/SG-β-galactosidase (CF1d) was also used for simultaneous saccharification and fermentation (SSF) of lactose.
34864183	4	22	theme	S.	583:584	arg1	cerevisiae/SG-β-galactosidase					586:614	S. cerevisiae/SG-β-galactosidase	583:614	S. cerevisiae/SG-β-galactosidase (CF1d)	583:621	S. cerevisiae/SG-β-galactosidase (CF1d) was also used for simultaneous saccharification and fermentation (SSF) of lactose.
34864183	2	23	theme	composite	277:285	arg1	biocatalysts					287:298	composite biocatalysts	277:298	composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG)	277:402	Therefore, two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG) were prepared for 5% w/v lactose fermentation.
34864183	2	23	theme	composite	277:285	arg1	CF1-CF2					301:307	CF1-CF2	301:307	CF1-CF2	301:307	Therefore, two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG) were prepared for 5% w/v lactose fermentation.
34864183	6	24	theme	lactic	979:984	arg1	yield					991:995	the theoretical lactic acid yield	963:995	the theoretical lactic acid yield	963:995	The wet CF1d resulted in 96% of the theoretical ethanol yield while the wet CF1b and freeze-dried CF2b resulted in 89% of the theoretical lactic acid yield.
34864183	0	25	theme	lactic	43:48	arg1	acid					50:53	lactic acid	43:53	lactic acid	43:53	Consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered cell factories.
34864183	6	26	theme	theoretical	967:977	arg1	yield					991:995	the theoretical lactic acid yield	963:995	the theoretical lactic acid yield	963:995	The wet CF1d resulted in 96% of the theoretical ethanol yield while the wet CF1b and freeze-dried CF2b resulted in 89% of the theoretical lactic acid yield.
34864183	6	27	theme	yield	991:995	arg1	%					958:958	89%	956:958	89% of the theoretical lactic acid yield	956:995	The wet CF1d resulted in 96% of the theoretical ethanol yield while the wet CF1b and freeze-dried CF2b resulted in 89% of the theoretical lactic acid yield.
34864183	6	27	theme	yield	991:995	arg1	yield					991:995	the theoretical lactic acid yield	963:995	the theoretical lactic acid yield	963:995	The wet CF1d resulted in 96% of the theoretical ethanol yield while the wet CF1b and freeze-dried CF2b resulted in 89% of the theoretical lactic acid yield.
34864183	5	28	theme	aforementioned	801:814	arg1	CF2a-c					832:837	CF2a-c	832:837	CF2a-c	832:837	In CF2, S. cerevisiae immobilized on tubular cellulose (TC) was covered with SG containing the aforementioned microorganisms (CF2a-c).
34864183	5	28	theme	aforementioned	801:814	arg1	microorganisms					816:829	the aforementioned microorganisms	797:829	the aforementioned microorganisms (CF2a-c)	797:838	In CF2, S. cerevisiae immobilized on tubular cellulose (TC) was covered with SG containing the aforementioned microorganisms (CF2a-c).
34864183	2	29	theme	lactose	429:435	arg1	fermentation					437:448	5% w/v lactose fermentation	422:448	5% w/v lactose fermentation	422:448	Therefore, two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG) were prepared for 5% w/v lactose fermentation.
34864183	6	30	theme	yield	897:901	arg1	yield					897:901	the theoretical ethanol yield	873:901	the theoretical ethanol yield	873:901	The wet CF1d resulted in 96% of the theoretical ethanol yield while the wet CF1b and freeze-dried CF2b resulted in 89% of the theoretical lactic acid yield.
34864183	6	30	theme	yield	897:901	arg1	%					868:868	96%	866:868	96% of the theoretical ethanol yield	866:901	The wet CF1d resulted in 96% of the theoretical ethanol yield while the wet CF1b and freeze-dried CF2b resulted in 89% of the theoretical lactic acid yield.
34864183	1	31	theme	non-engineered	206:219	arg1	CFs					237:239	CFs	237:239	CFs	237:239	The aim of this study is the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs).
34864183	1	31	theme	non-engineered	206:219	arg1	Factories					226:234	non-engineered Cell Factories	206:234	non-engineered Cell Factories (CFs)	206:240	The aim of this study is the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs).
34864183	2	32	theme	w/v	425:427	arg1	fermentation					437:448	5% w/v lactose fermentation	422:448	5% w/v lactose fermentation	422:448	Therefore, two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG) were prepared for 5% w/v lactose fermentation.
34864183	6	33	theme	ethanol	889:895	arg1	yield					897:901	the theoretical ethanol yield	873:901	the theoretical ethanol yield	873:901	The wet CF1d resulted in 96% of the theoretical ethanol yield while the wet CF1b and freeze-dried CF2b resulted in 89% of the theoretical lactic acid yield.
34864183	2	34	theme	Saccharomyces	319:331	arg1	cerevisiae					333:342	Saccharomyces cerevisiae	319:342	Saccharomyces cerevisiae	319:342	Therefore, two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG) were prepared for 5% w/v lactose fermentation.
34864183	2	35	theme	%	423:423	arg1	fermentation					437:448	5% w/v lactose fermentation	422:448	5% w/v lactose fermentation	422:448	Therefore, two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG) were prepared for 5% w/v lactose fermentation.
34864183	2	36	theme	starch	388:393	arg1	SG					400:401	SG	400:401	SG	400:401	Therefore, two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG) were prepared for 5% w/v lactose fermentation.
34864183	2	36	theme	starch	388:393	arg1	gel					395:397	starch gel	388:397	starch gel (SG)	388:402	Therefore, two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG) were prepared for 5% w/v lactose fermentation.
34864183	4	37	used	used	632:635	arg2	CF1d					617:620	CF1d	617:620	CF1d	617:620	S. cerevisiae/SG-β-galactosidase (CF1d) was also used for simultaneous saccharification and fermentation (SSF) of lactose.
34864183	4	37	used	used	632:635	arg2	cerevisiae/SG-β-galactosidase					586:614	S. cerevisiae/SG-β-galactosidase	583:614	S. cerevisiae/SG-β-galactosidase (CF1d)	583:621	S. cerevisiae/SG-β-galactosidase (CF1d) was also used for simultaneous saccharification and fermentation (SSF) of lactose.
34864183	3	38	contain	containing	493:502	arg2	bulgaricus					539:548	Lactobacillus bulgaricus	525:548	Lactobacillus bulgaricus	525:548	In CF1, S. cerevisiae was covered with SG containing Lactobacillus casei, Lactobacillus bulgaricus, Kluyveromyces marxianus CF1a-c.
34864183	3	38	contain	containing	493:502	arg1	SG					490:491	SG	490:491	SG containing Lactobacillus casei, Lactobacillus bulgaricus, Kluyveromyces marxianus CF1a-c	490:580	In CF1, S. cerevisiae was covered with SG containing Lactobacillus casei, Lactobacillus bulgaricus, Kluyveromyces marxianus CF1a-c.
34864183	3	38	contain	containing	493:502	arg2	Kluyveromyces					551:563	Kluyveromyces	551:563	Kluyveromyces	551:563	In CF1, S. cerevisiae was covered with SG containing Lactobacillus casei, Lactobacillus bulgaricus, Kluyveromyces marxianus CF1a-c.
34864183	3	38	contain	containing	493:502	arg2	casei					518:522	Lactobacillus casei	504:522	Lactobacillus casei	504:522	In CF1, S. cerevisiae was covered with SG containing Lactobacillus casei, Lactobacillus bulgaricus, Kluyveromyces marxianus CF1a-c.
34864183	1	39	theme	study	120:124	arg1	bioprocessing					146:158	the consolidated bioprocessing	129:158	the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs)	129:240	The aim of this study is the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs).
34864183	1	39	theme	study	120:124	arg1	aim					108:110	The aim	104:110	The aim of this study	104:124	The aim of this study is the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs).
34864183	1	40	theme	Cell	221:224	arg1	CFs					237:239	CFs	237:239	CFs	237:239	The aim of this study is the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs).
34864183	1	40	theme	Cell	221:224	arg1	Factories					226:234	non-engineered Cell Factories	206:234	non-engineered Cell Factories (CFs)	206:240	The aim of this study is the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs).
34864183	1	41	theme	consolidated	133:144	arg1	bioprocessing					146:158	the consolidated bioprocessing	129:158	the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs)	129:240	The aim of this study is the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs).
34864183	1	41	theme	consolidated	133:144	arg1	aim					108:110	The aim	104:110	The aim of this study	104:124	The aim of this study is the consolidated bioprocessing of lactose into lactic acid and ethanol using non-engineered Cell Factories (CFs).
34864183	8	42	theme	future	1169:1174	arg1	exploitation					1176:1187	future exploitation	1169:1187	future exploitation of whey	1169:1195	Subsequently, the freeze-dried CF2 as preservative and more manageable were verified for future exploitation of whey.
34864183	2	43	theme	immobilized	349:359	arg1	microorganism					361:373	microorganism	361:373	microorganism	361:373	Therefore, two different types of composite biocatalysts (CF1-CF2) based on Saccharomyces cerevisiae with immobilized microorganism or enzyme on starch gel (SG) were prepared for 5% w/v lactose fermentation.
33549663	0	0	theme	Cu2+	82:85	arg1	removal					71:77	the removal	67:77	the removal of Cu2+ and Co2	67:93	Synthesis of sodium lignosulfonate-guar gum composite hydrogel for the removal of Cu2+ and Co2.
33549663	3	1	theme	optimized	482:490	arg1	product					504:510	The optimized synthesized product	478:510	The optimized synthesized product	478:510	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	2	2	theme	porous	460:465	arg1	structure					467:475	porous structure	460:475	porous structure	460:475	In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure.
33549663	5	3	theme	Cu2+	1018:1021	arg1	adsorption					1004:1013	the successful adsorption	989:1013	the successful adsorption of Cu2+ and Co2+ by GG/SLS	989:1040	XPS results confirmed the successful adsorption of Cu2+ and Co2+ by GG/SLS.
33549663	2	4	theme	guar	340:343	arg1	gum					345:347	guar gum	340:347	guar gum	340:347	In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure.
33549663	0	5	theme	Co2	91:93	arg1	removal					71:77	the removal	67:77	the removal of Cu2+ and Co2	67:93	Synthesis of sodium lignosulfonate-guar gum composite hydrogel for the removal of Cu2+ and Co2.
33549663	8	6	theme	wastewater	1370:1379	arg1	material					1391:1398	a high-quality wastewater treatment material	1355:1398	a high-quality wastewater treatment material	1355:1398	These results provided valuable information for designing highly efficient adsorbents that can be used as a high-quality wastewater treatment material.
33549663	8	6	theme	wastewater	1370:1379	arg1	adsorbents					1324:1333	highly efficient adsorbents	1307:1333	highly efficient adsorbents that can be used as a high-quality wastewater treatment material	1307:1398	These results provided valuable information for designing highly efficient adsorbents that can be used as a high-quality wastewater treatment material.
33549663	8	7	theme	treatment	1381:1389	arg1	material					1391:1398	a high-quality wastewater treatment material	1355:1398	a high-quality wastewater treatment material	1355:1398	These results provided valuable information for designing highly efficient adsorbents that can be used as a high-quality wastewater treatment material.
33549663	8	7	theme	treatment	1381:1389	arg1	adsorbents					1324:1333	highly efficient adsorbents	1307:1333	highly efficient adsorbents that can be used as a high-quality wastewater treatment material	1307:1398	These results provided valuable information for designing highly efficient adsorbents that can be used as a high-quality wastewater treatment material.
33549663	2	8	theme	acid	271:274	arg1	material					251:258	a composite material	239:258	a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum	239:347	In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure.
33549663	4	9	theme	Co2+	902:905	arg1	adsorption					879:888	the adsorption	875:888	the adsorption of Cu2+ and Co2+ by the adsorbent	875:922	The adsorption kinetics and isotherms were well fitted by the pseudo second-order kinetic model and the Langmuir isotherm, showing that the adsorption of Cu2+ and Co2+ by the adsorbent belongs to the chemisorption on monolayer.
33549663	3	10	theme	Cu2+	699:702	arg1	capacities					643:652	the maximum ion adsorption capacities	616:652	the maximum ion adsorption capacities obtained	616:661	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	3	10	theme	Cu2+	699:702	arg1	709 mg g-1					685:694	709 mg g-1	685:694	709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively	685:736	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	4	11	theme	Langmuir	843:850	arg1	isotherm					852:859	the Langmuir isotherm	839:859	the Langmuir isotherm	839:859	The adsorption kinetics and isotherms were well fitted by the pseudo second-order kinetic model and the Langmuir isotherm, showing that the adsorption of Cu2+ and Co2+ by the adsorbent belongs to the chemisorption on monolayer.
33549663	7	12	theme	research	1185:1192	arg1	use					1168:1170	the use	1164:1170	the use of recycling research	1164:1192	In addition, the use of recycling research showed that the adsorbent has good chemical stability.
33549663	2	13	theme	acrylic	263:269	arg1	acid					271:274	acrylic acid	263:274	acrylic acid	263:274	In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure.
33549663	2	14	theme	grafted	306:312	arg1	lignosulfonate					321:334	grafted sodium lignosulfonate	306:334	grafted sodium lignosulfonate	306:334	In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure.
33549663	4	15	theme	second-order	808:819	arg1	model					829:833	the pseudo second-order kinetic model	797:833	the pseudo second-order kinetic model	797:833	The adsorption kinetics and isotherms were well fitted by the pseudo second-order kinetic model and the Langmuir isotherm, showing that the adsorption of Cu2+ and Co2+ by the adsorbent belongs to the chemisorption on monolayer.
33549663	4	16	theme	adsorption	743:752	arg1	kinetics					754:761	The adsorption kinetics	739:761	The adsorption kinetics	739:761	The adsorption kinetics and isotherms were well fitted by the pseudo second-order kinetic model and the Langmuir isotherm, showing that the adsorption of Cu2+ and Co2+ by the adsorbent belongs to the chemisorption on monolayer.
33549663	0	17	theme	hydrogel	54:61	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of sodium lignosulfonate-guar gum composite hydrogel for the removal of Cu2+ and Co2.	0:94	Synthesis of sodium lignosulfonate-guar gum composite hydrogel for the removal of Cu2+ and Co2.
33549663	4	18	theme	pseudo	801:806	arg1	model					829:833	the pseudo second-order kinetic model	797:833	the pseudo second-order kinetic model	797:833	The adsorption kinetics and isotherms were well fitted by the pseudo second-order kinetic model and the Langmuir isotherm, showing that the adsorption of Cu2+ and Co2+ by the adsorbent belongs to the chemisorption on monolayer.
33549663	6	19	theme	Surface	1043:1049	arg1	mechanism					1092:1100	the main mechanism	1083:1100	the main mechanism for GG/SLS adsorbent to remove heavy metal ions	1083:1148	Surface complexation was proposed to be the main mechanism for GG/SLS adsorbent to remove heavy metal ions.
33549663	6	19	theme	Surface	1043:1049	arg1	complexation					1051:1062	Surface complexation	1043:1062	Surface complexation	1043:1062	Surface complexation was proposed to be the main mechanism for GG/SLS adsorbent to remove heavy metal ions.
33549663	2	20	dep	monomer	298:304	arg1	lignosulfonate					321:334	grafted sodium lignosulfonate	306:334	grafted sodium lignosulfonate	306:334	In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure.
33549663	2	21	theme	abundant	422:429	arg1	groups					449:454	its abundant active functional groups	418:454	its abundant active functional groups	418:454	In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure.
33549663	7	22	contain	has	1220:1222	arg1	adsorbent					1210:1218	adsorbent	1210:1218	adsorbent	1210:1218	In addition, the use of recycling research showed that the adsorbent has good chemical stability.
33549663	7	22	contain	has	1220:1222	arg2	stability					1238:1246	good chemical stability	1224:1246	good chemical stability	1224:1246	In addition, the use of recycling research showed that the adsorbent has good chemical stability.
33549663	6	23	theme	adsorbent	1113:1121	arg1	GG/SLS					1106:1111	GG/SLS	1106:1111	GG/SLS adsorbent to remove heavy metal ions	1106:1148	Surface complexation was proposed to be the main mechanism for GG/SLS adsorbent to remove heavy metal ions.
33549663	3	24	theme	Co2+	719:722	arg1	601 mg g-1					705:714	601 mg g-1	705:714	601 mg g-1 of Co2+	705:722	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	3	24	theme	Co2+	719:722	arg1	Cu2+					699:702	Cu2+	699:702	Cu2+	699:702	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	4	25	theme	kinetic	821:827	arg1	model					829:833	the pseudo second-order kinetic model	797:833	the pseudo second-order kinetic model	797:833	The adsorption kinetics and isotherms were well fitted by the pseudo second-order kinetic model and the Langmuir isotherm, showing that the adsorption of Cu2+ and Co2+ by the adsorbent belongs to the chemisorption on monolayer.
33549663	2	26	theme	polymerization	283:296	arg1	monomer					298:304	the polymerization monomer grafted sodium lignosulfonate and guar gum	279:347	monomer	298:304	In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure.
33549663	1	27	theme	good	167:170	arg1	capacity					183:190	its good adsorption capacity	163:190	its good adsorption capacity	163:190	As an emerging pollutant treatment material, hydrogel is known for its good adsorption capacity and environmental friendliness.
33549663	0	28	theme	lignosulfonate-guar	20:38	arg1	hydrogel					54:61	sodium lignosulfonate-guar gum composite hydrogel	13:61	sodium lignosulfonate-guar gum composite hydrogel	13:61	Synthesis of sodium lignosulfonate-guar gum composite hydrogel for the removal of Cu2+ and Co2.
33549663	8	29	theme	valuable	1272:1279	arg1	information					1281:1291	valuable information	1272:1291	valuable information for designing highly efficient adsorbents that can be used as a high-quality wastewater treatment material	1272:1398	These results provided valuable information for designing highly efficient adsorbents that can be used as a high-quality wastewater treatment material.
33549663	8	30	used	used	1347:1350	arg2	material					1391:1398	a high-quality wastewater treatment material	1355:1398	a high-quality wastewater treatment material	1355:1398	These results provided valuable information for designing highly efficient adsorbents that can be used as a high-quality wastewater treatment material.
33549663	8	30	used	used	1347:1350	arg2	adsorbents					1324:1333	highly efficient adsorbents	1307:1333	highly efficient adsorbents that can be used as a high-quality wastewater treatment material	1307:1398	These results provided valuable information for designing highly efficient adsorbents that can be used as a high-quality wastewater treatment material.
33549663	2	31	theme	metal	402:406	arg1	ions					408:411	metal ions	402:411	metal ions	402:411	In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure.
33549663	0	32	theme	sodium	13:18	arg1	hydrogel					54:61	sodium lignosulfonate-guar gum composite hydrogel	13:61	sodium lignosulfonate-guar gum composite hydrogel	13:61	Synthesis of sodium lignosulfonate-guar gum composite hydrogel for the removal of Cu2+ and Co2.
33549663	8	33	theme	efficient	1314:1322	arg1	material					1391:1398	a high-quality wastewater treatment material	1355:1398	a high-quality wastewater treatment material	1355:1398	These results provided valuable information for designing highly efficient adsorbents that can be used as a high-quality wastewater treatment material.
33549663	8	33	theme	efficient	1314:1322	arg1	adsorbents					1324:1333	highly efficient adsorbents	1307:1333	highly efficient adsorbents that can be used as a high-quality wastewater treatment material	1307:1398	These results provided valuable information for designing highly efficient adsorbents that can be used as a high-quality wastewater treatment material.
33549663	5	34	theme	Co2+	1027:1030	arg1	adsorption					1004:1013	the successful adsorption	989:1013	the successful adsorption of Cu2+ and Co2+ by GG/SLS	989:1040	XPS results confirmed the successful adsorption of Cu2+ and Co2+ by GG/SLS.
33549663	3	35	theme	Cu2+	542:545	arg1	removal					531:537	the removal	527:537	the removal of Cu2+ and Co2+	527:554	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	0	36	theme	composite	44:52	arg1	hydrogel					54:61	sodium lignosulfonate-guar gum composite hydrogel	13:61	sodium lignosulfonate-guar gum composite hydrogel	13:61	Synthesis of sodium lignosulfonate-guar gum composite hydrogel for the removal of Cu2+ and Co2.
33549663	7	37	theme	good	1224:1227	arg1	stability					1238:1246	good chemical stability	1224:1246	good chemical stability	1224:1246	In addition, the use of recycling research showed that the adsorbent has good chemical stability.
33549663	3	38	theme	maximum	620:626	arg1	capacities					643:652	the maximum ion adsorption capacities	616:652	the maximum ion adsorption capacities obtained	616:661	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	3	38	theme	maximum	620:626	arg1	709 mg g-1					685:694	709 mg g-1	685:694	709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively	685:736	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	3	39	theme	one-component	561:573	arg1	system					575:580	a one-component system	559:580	a one-component system	559:580	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	7	40	theme	chemical	1229:1236	arg1	stability					1238:1246	good chemical stability	1224:1246	good chemical stability	1224:1246	In addition, the use of recycling research showed that the adsorbent has good chemical stability.
33549663	0	41	theme	gum	40:42	arg1	hydrogel					54:61	sodium lignosulfonate-guar gum composite hydrogel	13:61	sodium lignosulfonate-guar gum composite hydrogel	13:61	Synthesis of sodium lignosulfonate-guar gum composite hydrogel for the removal of Cu2+ and Co2.
33549663	4	42	theme	Cu2+	893:896	arg1	adsorption					879:888	the adsorption	875:888	the adsorption of Cu2+ and Co2+ by the adsorbent	875:922	The adsorption kinetics and isotherms were well fitted by the pseudo second-order kinetic model and the Langmuir isotherm, showing that the adsorption of Cu2+ and Co2+ by the adsorbent belongs to the chemisorption on monolayer.
33549663	1	43	theme	environmental	196:208	arg1	friendliness					210:221	environmental friendliness	196:221	environmental friendliness	196:221	As an emerging pollutant treatment material, hydrogel is known for its good adsorption capacity and environmental friendliness.
33549663	2	44	theme	functional	438:447	arg1	groups					449:454	its abundant active functional groups	418:454	its abundant active functional groups	418:454	In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure.
33549663	8	45	theme	high-quality	1357:1368	arg1	material					1391:1398	a high-quality wastewater treatment material	1355:1398	a high-quality wastewater treatment material	1355:1398	These results provided valuable information for designing highly efficient adsorbents that can be used as a high-quality wastewater treatment material.
33549663	8	45	theme	high-quality	1357:1368	arg1	adsorbents					1324:1333	highly efficient adsorbents	1307:1333	highly efficient adsorbents that can be used as a high-quality wastewater treatment material	1307:1398	These results provided valuable information for designing highly efficient adsorbents that can be used as a high-quality wastewater treatment material.
33549663	6	46	theme	main	1087:1090	arg1	mechanism					1092:1100	the main mechanism	1083:1100	the main mechanism for GG/SLS adsorbent to remove heavy metal ions	1083:1148	Surface complexation was proposed to be the main mechanism for GG/SLS adsorbent to remove heavy metal ions.
33549663	6	46	theme	main	1087:1090	arg1	complexation					1051:1062	Surface complexation	1043:1062	Surface complexation	1043:1062	Surface complexation was proposed to be the main mechanism for GG/SLS adsorbent to remove heavy metal ions.
33549663	2	47	theme	active	431:436	arg1	groups					449:454	its abundant active functional groups	418:454	its abundant active functional groups	418:454	In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure.
33549663	6	48	theme	heavy	1133:1137	arg1	ions					1145:1148	heavy metal ions	1133:1148	heavy metal ions	1133:1148	Surface complexation was proposed to be the main mechanism for GG/SLS adsorbent to remove heavy metal ions.
33549663	5	49	theme	successful	993:1002	arg1	adsorption					1004:1013	the successful adsorption	989:1013	the successful adsorption of Cu2+ and Co2+ by GG/SLS	989:1040	XPS results confirmed the successful adsorption of Cu2+ and Co2+ by GG/SLS.
33549663	3	50	theme	synthesized	492:502	arg1	product					504:510	The optimized synthesized product	478:510	The optimized synthesized product	478:510	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	1	51	theme	emerging	102:109	arg1	pollutant					111:119	an emerging pollutant	99:119	an emerging pollutant treatment material	99:138	As an emerging pollutant treatment material, hydrogel is known for its good adsorption capacity and environmental friendliness.
33549663	3	52	theme	multi-component	588:602	arg1	system					604:609	a multi-component system	586:609	a multi-component system	586:609	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	2	53	theme	composite	241:249	arg1	material					251:258	a composite material	239:258	a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum	239:347	In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure.
33549663	1	54	theme	pollutant	111:119	arg1	hydrogel					141:148	hydrogel	141:148	hydrogel	141:148	As an emerging pollutant treatment material, hydrogel is known for its good adsorption capacity and environmental friendliness.
33549663	1	54	theme	pollutant	111:119	arg1	material					131:138	an emerging pollutant treatment material	99:138	an emerging pollutant treatment material	99:138	As an emerging pollutant treatment material, hydrogel is known for its good adsorption capacity and environmental friendliness.
33549663	4	55	from	chemisorption	939:951	arg1	monolayer					956:964	monolayer	956:964	monolayer	956:964	The adsorption kinetics and isotherms were well fitted by the pseudo second-order kinetic model and the Langmuir isotherm, showing that the adsorption of Cu2+ and Co2+ by the adsorbent belongs to the chemisorption on monolayer.
33549663	3	56	theme	ion	628:630	arg1	capacities					643:652	the maximum ion adsorption capacities	616:652	the maximum ion adsorption capacities obtained	616:661	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	3	56	theme	ion	628:630	arg1	709 mg g-1					685:694	709 mg g-1	685:694	709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively	685:736	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	6	57	theme	metal	1139:1143	arg1	ions					1145:1148	heavy metal ions	1133:1148	heavy metal ions	1133:1148	Surface complexation was proposed to be the main mechanism for GG/SLS adsorbent to remove heavy metal ions.
33549663	1	58	theme	treatment	121:129	arg1	hydrogel					141:148	hydrogel	141:148	hydrogel	141:148	As an emerging pollutant treatment material, hydrogel is known for its good adsorption capacity and environmental friendliness.
33549663	1	58	theme	treatment	121:129	arg1	material					131:138	an emerging pollutant treatment material	99:138	an emerging pollutant treatment material	99:138	As an emerging pollutant treatment material, hydrogel is known for its good adsorption capacity and environmental friendliness.
33549663	2	59	theme	sodium	314:319	arg1	lignosulfonate					321:334	grafted sodium lignosulfonate	306:334	grafted sodium lignosulfonate	306:334	In this study, a composite material of acrylic acid as the polymerization monomer grafted sodium lignosulfonate and guar gum was prepared, which provided a channel for adsorbing metal ions with its abundant active functional groups and porous structure.
33549663	3	60	theme	adsorption	632:641	arg1	capacities					643:652	the maximum ion adsorption capacities	616:652	the maximum ion adsorption capacities obtained	616:661	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	3	60	theme	adsorption	632:641	arg1	709 mg g-1					685:694	709 mg g-1	685:694	709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively	685:736	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	1	61	theme	adsorption	172:181	arg1	capacity					183:190	its good adsorption capacity	163:190	its good adsorption capacity	163:190	As an emerging pollutant treatment material, hydrogel is known for its good adsorption capacity and environmental friendliness.
33549663	5	62	theme	XPS	967:969	arg1	results					971:977	XPS results	967:977	XPS results	967:977	XPS results confirmed the successful adsorption of Cu2+ and Co2+ by GG/SLS.
33549663	3	63	theme	Co2+	551:554	arg1	removal					531:537	the removal	527:537	the removal of Cu2+ and Co2+	527:554	The optimized synthesized product was applied to the removal of Cu2+ and Co2+ in a one-component system and a multi-component system, and the maximum ion adsorption capacities obtained were determined to be 709 mg g-1 of Cu2+, 601 mg g-1 of Co2+, respectively.
33549663	7	64	theme	recycling	1175:1183	arg1	research					1185:1192	recycling research	1175:1192	recycling research	1175:1192	In addition, the use of recycling research showed that the adsorbent has good chemical stability.
34710480	2	0	theme	porcine	453:459	arg1	liver					461:465	porcine liver	453:465	porcine liver	453:465	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	4	1	theme	further	928:934	arg1	consideration					936:948	further consideration	928:948	further consideration	928:948	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	4	2	theme	in-vitro	817:824	arg1	cytocompatibility					826:842	in-vitro cytocompatibility	817:842	in-vitro cytocompatibility	817:842	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	4	3	from	analysis	735:742	arg1	kinetics					804:811	the microstructure, in-vitro degradation, and blood clot kinetics	747:811	the microstructure, in-vitro degradation, and blood clot kinetics	747:811	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	4	3	from	analysis	735:742	arg1	cytocompatibility					826:842	in-vitro cytocompatibility	817:842	in-vitro cytocompatibility	817:842	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	0	4	theme	matrix	80:85	arg1	evaluation					30:39	In-vitro and in-vivo hemostat evaluation	0:39	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix	0:85	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix loaded chitosan/gelatin spongy scaffolds for liver injury.
34710480	7	5	theme	hemorrhage	1417:1426	arg1	prevention					1393:1402	the prevention	1389:1402	the prevention of excessive hemorrhage during surgeries	1389:1443	In the present study, we demonstrated that, CG with dLECM spongy scaffold as a potential hemostatic material in the prevention of excessive hemorrhage during surgeries.
34710480	1	6	used	used	212:215	arg2	C					170:170	C	170:170	C	170:170	Individually, Chitosan (C) and Gelatin (G) are increasingly being used for the simulation and testing of surgical procedures.
34710480	1	6	used	used	212:215	arg2	Chitosan					160:167	Chitosan	160:167	Chitosan (C)	160:171	Individually, Chitosan (C) and Gelatin (G) are increasingly being used for the simulation and testing of surgical procedures.
34710480	1	6	used	used	212:215	arg2	G					186:186	G	186:186	G	186:186	Individually, Chitosan (C) and Gelatin (G) are increasingly being used for the simulation and testing of surgical procedures.
34710480	1	6	used	used	212:215	arg2	Gelatin					177:183	Gelatin	177:183	Gelatin (G)	177:187	Individually, Chitosan (C) and Gelatin (G) are increasingly being used for the simulation and testing of surgical procedures.
34710480	7	7	from	material	1377:1384	arg1	prevention					1393:1402	the prevention	1389:1402	the prevention of excessive hemorrhage during surgeries	1389:1443	In the present study, we demonstrated that, CG with dLECM spongy scaffold as a potential hemostatic material in the prevention of excessive hemorrhage during surgeries.
34710480	0	8	theme	spongy	111:116	arg1	scaffolds					118:126	chitosan/gelatin spongy scaffolds	94:126	chitosan/gelatin spongy scaffolds	94:126	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix loaded chitosan/gelatin spongy scaffolds for liver injury.
34710480	7	9	theme	present	1284:1290	arg1	study					1292:1296	the present study	1280:1296	the present study	1280:1296	In the present study, we demonstrated that, CG with dLECM spongy scaffold as a potential hemostatic material in the prevention of excessive hemorrhage during surgeries.
34710480	2	10	theme	liver	578:582	arg1	surgery					584:590	liver surgery	578:590	liver surgery	578:590	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	2	11	theme	CG-dLECM	484:491	arg1	combination					493:503	CG-dLECM combination	484:503	CG-dLECM combination	484:503	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	7	12	theme	potential	1356:1364	arg1	material					1377:1384	a potential hemostatic material	1354:1384	a potential hemostatic material in the prevention of excessive hemorrhage during surgeries	1354:1443	In the present study, we demonstrated that, CG with dLECM spongy scaffold as a potential hemostatic material in the prevention of excessive hemorrhage during surgeries.
34710480	5	13	with	recovery	1015:1022	arg1	absorption					1044:1053	a higher blood absorption	1029:1053	a higher blood absorption	1029:1053	The prepared CG-E4 spongy scaffold enhances fast post-operative recovery with a higher blood absorption and fast clotting time (~50 s).
34710480	6	14	theme	accelerated	1245:1255	arg1	regeneration					1263:1274	accelerated liver regeneration	1245:1274	accelerated liver regeneration	1245:1274	In addition, CG-E4 spongy scaffold implanted at rat liver wound showed desired biocompatibility as evidenced by reduced wound size, earlier bioabsorption and accelerated liver regeneration.
34710480	5	15	theme	fast	1059:1062	arg1	~50 s					1079:1083	~50 s	1079:1083	~50 s	1079:1083	The prepared CG-E4 spongy scaffold enhances fast post-operative recovery with a higher blood absorption and fast clotting time (~50 s).
34710480	5	15	theme	fast	1059:1062	arg1	time					1073:1076	fast clotting time	1059:1076	fast clotting time (~50 s)	1059:1084	The prepared CG-E4 spongy scaffold enhances fast post-operative recovery with a higher blood absorption and fast clotting time (~50 s).
34710480	2	16	theme	wound	519:523	arg1	healing					525:531	wound healing	519:531	wound healing	519:531	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	4	17	theme	Preliminary	723:733	arg1	analysis					735:742	Preliminary analysis	723:742	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility	723:842	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	4	18	theme	4 mg/ml	868:874	arg1	dLECM					876:880	4 mg/ml dLECM	868:880	4 mg/ml dLECM (CG-E4)	868:888	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	4	18	theme	4 mg/ml	868:874	arg1	CG-E4					883:887	CG-E4	883:887	CG-E4	883:887	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	5	19	theme	clotting	1064:1071	arg1	~50 s					1079:1083	~50 s	1079:1083	~50 s	1079:1083	The prepared CG-E4 spongy scaffold enhances fast post-operative recovery with a higher blood absorption and fast clotting time (~50 s).
34710480	5	19	theme	clotting	1064:1071	arg1	time					1073:1076	fast clotting time	1059:1076	fast clotting time (~50 s)	1059:1084	The prepared CG-E4 spongy scaffold enhances fast post-operative recovery with a higher blood absorption and fast clotting time (~50 s).
34710480	4	20	theme	microstructure	751:764	arg1	kinetics					804:811	the microstructure, in-vitro degradation, and blood clot kinetics	747:811	the microstructure, in-vitro degradation, and blood clot kinetics	747:811	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	2	21	theme	matrix	417:422	arg1	dLECM					432:436	dLECM	432:436	dLECM	432:436	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	2	21	theme	matrix	417:422	arg1	powder					424:429	the loading decellularized liver extracellular matrix powder	370:429	the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver	370:465	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	7	22	theme	dLECM	1329:1333	arg1	scaffold					1342:1349	dLECM spongy scaffold	1329:1349	dLECM spongy scaffold	1329:1349	In the present study, we demonstrated that, CG with dLECM spongy scaffold as a potential hemostatic material in the prevention of excessive hemorrhage during surgeries.
34710480	6	23	theme	reduced	1199:1205	arg1	size					1213:1216	reduced wound size	1199:1216	reduced wound size	1199:1216	In addition, CG-E4 spongy scaffold implanted at rat liver wound showed desired biocompatibility as evidenced by reduced wound size, earlier bioabsorption and accelerated liver regeneration.
34710480	6	24	theme	CG-E4	1100:1104	arg1	scaffold					1113:1120	CG-E4 spongy scaffold	1100:1120	CG-E4 spongy scaffold implanted at rat liver wound	1100:1149	In addition, CG-E4 spongy scaffold implanted at rat liver wound showed desired biocompatibility as evidenced by reduced wound size, earlier bioabsorption and accelerated liver regeneration.
34710480	7	25	theme	excessive	1407:1415	arg1	hemorrhage					1417:1426	excessive hemorrhage	1407:1426	excessive hemorrhage during surgeries	1407:1443	In the present study, we demonstrated that, CG with dLECM spongy scaffold as a potential hemostatic material in the prevention of excessive hemorrhage during surgeries.
34710480	0	26	theme	In-vitro	0:7	arg1	evaluation					30:39	In-vitro and in-vivo hemostat evaluation	0:39	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix	0:85	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix loaded chitosan/gelatin spongy scaffolds for liver injury.
34710480	1	27	theme	surgical	251:258	arg1	procedures					260:269	surgical procedures	251:269	surgical procedures	251:269	Individually, Chitosan (C) and Gelatin (G) are increasingly being used for the simulation and testing of surgical procedures.
34710480	4	28	theme	clot	799:802	arg1	kinetics					804:811	the microstructure, in-vitro degradation, and blood clot kinetics	747:811	the microstructure, in-vitro degradation, and blood clot kinetics	747:811	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	5	29	theme	CG-E4	964:968	arg1	scaffold					977:984	The prepared CG-E4 spongy scaffold	951:984	The prepared CG-E4 spongy scaffold	951:984	The prepared CG-E4 spongy scaffold enhances fast post-operative recovery with a higher blood absorption and fast clotting time (~50 s).
34710480	4	30	theme	blood	793:797	arg1	clot					799:802	blood clot	793:802	blood clot	793:802	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	0	31	theme	hemostat	21:28	arg1	evaluation					30:39	In-vitro and in-vivo hemostat evaluation	0:39	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix	0:85	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix loaded chitosan/gelatin spongy scaffolds for liver injury.
34710480	1	32	theme	procedures	260:269	arg1	testing					240:246	testing	240:246	testing	240:246	Individually, Chitosan (C) and Gelatin (G) are increasingly being used for the simulation and testing of surgical procedures.
34710480	1	32	theme	procedures	260:269	arg1	simulation					225:234	simulation	225:234	simulation	225:234	Individually, Chitosan (C) and Gelatin (G) are increasingly being used for the simulation and testing of surgical procedures.
34710480	6	33	theme	desired	1158:1164	arg1	biocompatibility					1166:1181	desired biocompatibility	1158:1181	desired biocompatibility	1158:1181	In addition, CG-E4 spongy scaffold implanted at rat liver wound showed desired biocompatibility as evidenced by reduced wound size, earlier bioabsorption and accelerated liver regeneration.
34710480	2	34	theme	present	279:285	arg1	study					287:291	the present study	275:291	the present study	275:291	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	4	35	with	CG	860:861	arg1	dLECM					876:880	4 mg/ml dLECM	868:880	4 mg/ml dLECM (CG-E4)	868:888	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	4	35	with	CG	860:861	arg1	CG-E4					883:887	CG-E4	883:887	CG-E4	883:887	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	2	36	theme	decellularized	382:395	arg1	dLECM					432:436	dLECM	432:436	dLECM	432:436	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	2	36	theme	decellularized	382:395	arg1	powder					424:429	the loading decellularized liver extracellular matrix powder	370:429	the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver	370:465	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	2	37	theme	liver	397:401	arg1	dLECM					432:436	dLECM	432:436	dLECM	432:436	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	2	37	theme	liver	397:401	arg1	powder					424:429	the loading decellularized liver extracellular matrix powder	370:429	the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver	370:465	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	0	38	theme	liver	132:136	arg1	injury					138:143	liver injury	132:143	liver injury	132:143	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix loaded chitosan/gelatin spongy scaffolds for liver injury.
34710480	6	39	theme	liver	1139:1143	arg1	wound					1145:1149	rat liver wound	1135:1149	rat liver wound	1135:1149	In addition, CG-E4 spongy scaffold implanted at rat liver wound showed desired biocompatibility as evidenced by reduced wound size, earlier bioabsorption and accelerated liver regeneration.
34710480	2	40	theme	loading	374:380	arg1	dLECM					432:436	dLECM	432:436	dLECM	432:436	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	2	40	theme	loading	374:380	arg1	powder					424:429	the loading decellularized liver extracellular matrix powder	370:429	the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver	370:465	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	5	41	theme	higher	1031:1036	arg1	absorption					1044:1053	a higher blood absorption	1029:1053	a higher blood absorption	1029:1053	The prepared CG-E4 spongy scaffold enhances fast post-operative recovery with a higher blood absorption and fast clotting time (~50 s).
34710480	4	42	theme	in-vitro	767:774	arg1	degradation					776:786	in-vitro degradation	767:786	in-vitro degradation	767:786	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	6	43	theme	rat	1135:1137	arg1	wound					1145:1149	rat liver wound	1135:1149	rat liver wound	1135:1149	In addition, CG-E4 spongy scaffold implanted at rat liver wound showed desired biocompatibility as evidenced by reduced wound size, earlier bioabsorption and accelerated liver regeneration.
34710480	6	44	theme	wound	1207:1211	arg1	size					1213:1216	reduced wound size	1199:1216	reduced wound size	1199:1216	In addition, CG-E4 spongy scaffold implanted at rat liver wound showed desired biocompatibility as evidenced by reduced wound size, earlier bioabsorption and accelerated liver regeneration.
34710480	7	45	theme	spongy	1335:1340	arg1	scaffold					1342:1349	dLECM spongy scaffold	1329:1349	dLECM spongy scaffold	1329:1349	In the present study, we demonstrated that, CG with dLECM spongy scaffold as a potential hemostatic material in the prevention of excessive hemorrhage during surgeries.
34710480	5	46	theme	blood	1038:1042	arg1	absorption					1044:1053	a higher blood absorption	1029:1053	a higher blood absorption	1029:1053	The prepared CG-E4 spongy scaffold enhances fast post-operative recovery with a higher blood absorption and fast clotting time (~50 s).
34710480	2	47	theme	extracellular	403:415	arg1	dLECM					432:436	dLECM	432:436	dLECM	432:436	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	2	47	theme	extracellular	403:415	arg1	powder					424:429	the loading decellularized liver extracellular matrix powder	370:429	the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver	370:465	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	3	48	dep	dLECM	618:622	arg1	4					628:628	4	628:628	4	628:628	Varying concentration of dLECM (1, 4, and 8 mg/ml) were loaded into CG, and evaluation was done to get the optimized composition.
34710480	3	48	dep	dLECM	618:622	arg1	8 mg/ml					635:641	8 mg/ml	635:641	8 mg/ml	635:641	Varying concentration of dLECM (1, 4, and 8 mg/ml) were loaded into CG, and evaluation was done to get the optimized composition.
34710480	3	48	dep	dLECM	618:622	arg1	1					625:625	1	625:625	1	625:625	Varying concentration of dLECM (1, 4, and 8 mg/ml) were loaded into CG, and evaluation was done to get the optimized composition.
34710480	0	49	theme	liver	59:63	arg1	matrix					80:85	decellularized liver extra cellular matrix	44:85	decellularized liver extra cellular matrix	44:85	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix loaded chitosan/gelatin spongy scaffolds for liver injury.
34710480	4	50	theme	suitable	903:910	arg1	CG					860:861	the CG	856:861	the CG with 4 mg/ml dLECM (CG-E4)	856:888	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	4	50	theme	suitable	903:910	arg1	composition					912:922	the most suitable composition	894:922	the most suitable composition for further consideration	894:948	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	2	51	theme	chitosan/gelatin	312:327	arg1	combination					297:307	combination	297:307	combination of chitosan/gelatin (CG)	297:332	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	0	52	theme	decellularized	44:57	arg1	matrix					80:85	decellularized liver extra cellular matrix	44:85	decellularized liver extra cellular matrix	44:85	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix loaded chitosan/gelatin spongy scaffolds for liver injury.
34710480	3	53	theme	optimized	700:708	arg1	composition					710:720	the optimized composition	696:720	the optimized composition	696:720	Varying concentration of dLECM (1, 4, and 8 mg/ml) were loaded into CG, and evaluation was done to get the optimized composition.
34710480	2	54	theme	postoperative	544:556	arg1	complications					558:570	postoperative complications	544:570	postoperative complications after liver surgery	544:590	In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery.
34710480	5	55	theme	fast	995:998	arg1	recovery					1015:1022	fast post-operative recovery	995:1022	fast post-operative recovery with a higher blood absorption	995:1053	The prepared CG-E4 spongy scaffold enhances fast post-operative recovery with a higher blood absorption and fast clotting time (~50 s).
34710480	4	56	theme	degradation	776:786	arg1	kinetics					804:811	the microstructure, in-vitro degradation, and blood clot kinetics	747:811	the microstructure, in-vitro degradation, and blood clot kinetics	747:811	Preliminary analysis on the microstructure, in-vitro degradation, and blood clot kinetics and in-vitro cytocompatibility showed that the CG with 4 mg/ml dLECM (CG-E4) was the most suitable composition for further consideration.
34710480	7	57	theme	hemostatic	1366:1375	arg1	material					1377:1384	a potential hemostatic material	1354:1384	a potential hemostatic material in the prevention of excessive hemorrhage during surgeries	1354:1443	In the present study, we demonstrated that, CG with dLECM spongy scaffold as a potential hemostatic material in the prevention of excessive hemorrhage during surgeries.
34710480	6	58	theme	earlier	1219:1225	arg1	bioabsorption					1227:1239	earlier bioabsorption	1219:1239	earlier bioabsorption	1219:1239	In addition, CG-E4 spongy scaffold implanted at rat liver wound showed desired biocompatibility as evidenced by reduced wound size, earlier bioabsorption and accelerated liver regeneration.
34710480	5	59	theme	prepared	955:962	arg1	scaffold					977:984	The prepared CG-E4 spongy scaffold	951:984	The prepared CG-E4 spongy scaffold	951:984	The prepared CG-E4 spongy scaffold enhances fast post-operative recovery with a higher blood absorption and fast clotting time (~50 s).
34710480	6	60	theme	liver	1257:1261	arg1	regeneration					1263:1274	accelerated liver regeneration	1245:1274	accelerated liver regeneration	1245:1274	In addition, CG-E4 spongy scaffold implanted at rat liver wound showed desired biocompatibility as evidenced by reduced wound size, earlier bioabsorption and accelerated liver regeneration.
34710480	5	61	theme	post-operative	1000:1013	arg1	recovery					1015:1022	fast post-operative recovery	995:1022	fast post-operative recovery with a higher blood absorption	995:1053	The prepared CG-E4 spongy scaffold enhances fast post-operative recovery with a higher blood absorption and fast clotting time (~50 s).
34710480	5	62	theme	spongy	970:975	arg1	scaffold					977:984	The prepared CG-E4 spongy scaffold	951:984	The prepared CG-E4 spongy scaffold	951:984	The prepared CG-E4 spongy scaffold enhances fast post-operative recovery with a higher blood absorption and fast clotting time (~50 s).
34710480	5	63	with	time	1073:1076	arg1	absorption					1044:1053	a higher blood absorption	1029:1053	a higher blood absorption	1029:1053	The prepared CG-E4 spongy scaffold enhances fast post-operative recovery with a higher blood absorption and fast clotting time (~50 s).
34710480	6	64	theme	spongy	1106:1111	arg1	scaffold					1113:1120	CG-E4 spongy scaffold	1100:1120	CG-E4 spongy scaffold implanted at rat liver wound	1100:1149	In addition, CG-E4 spongy scaffold implanted at rat liver wound showed desired biocompatibility as evidenced by reduced wound size, earlier bioabsorption and accelerated liver regeneration.
34710480	1	65	dep	simulation	225:234	arg1	the					221:223	the	221:223	the	221:223	Individually, Chitosan (C) and Gelatin (G) are increasingly being used for the simulation and testing of surgical procedures.
34710480	3	66	theme	dLECM	618:622	arg1	concentration					601:613	Varying concentration	593:613	Varying concentration of dLECM (1, 4, and 8 mg/ml)	593:642	Varying concentration of dLECM (1, 4, and 8 mg/ml) were loaded into CG, and evaluation was done to get the optimized composition.
34710480	0	67	theme	cellular	71:78	arg1	matrix					80:85	decellularized liver extra cellular matrix	44:85	decellularized liver extra cellular matrix	44:85	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix loaded chitosan/gelatin spongy scaffolds for liver injury.
34710480	3	68	theme	Varying	593:599	arg1	concentration					601:613	Varying concentration	593:613	Varying concentration of dLECM (1, 4, and 8 mg/ml)	593:642	Varying concentration of dLECM (1, 4, and 8 mg/ml) were loaded into CG, and evaluation was done to get the optimized composition.
34710480	0	69	theme	extra	65:69	arg1	matrix					80:85	decellularized liver extra cellular matrix	44:85	decellularized liver extra cellular matrix	44:85	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix loaded chitosan/gelatin spongy scaffolds for liver injury.
34710480	0	70	theme	in-vivo	13:19	arg1	evaluation					30:39	In-vitro and in-vivo hemostat evaluation	0:39	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix	0:85	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix loaded chitosan/gelatin spongy scaffolds for liver injury.
34710480	0	71	theme	chitosan/gelatin	94:109	arg1	scaffolds					118:126	chitosan/gelatin spongy scaffolds	94:126	chitosan/gelatin spongy scaffolds	94:126	In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix loaded chitosan/gelatin spongy scaffolds for liver injury.
33827063	8	0	theme	bone	1349:1352	arg1	regeneration					1354:1365	bone regeneration	1349:1365	bone regeneration	1349:1365	In conclusion, through CS modification, our novel CS-MPCs have improved physiochemical properties that enhance compatibilityin vitroand bone regenerationin vivo, making them attractive materials for bone regeneration.
33827063	5	1	theme	higher	858:863	arg1	strength					877:884	higher compressive strength	858:884	higher compressive strength	858:884	CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC.
33827063	8	2	theme	novel	1194:1198	arg1	CS-MPCs					1200:1206	our novel CS-MPCs	1190:1206	our novel CS-MPCs	1190:1206	In conclusion, through CS modification, our novel CS-MPCs have improved physiochemical properties that enhance compatibilityin vitroand bone regenerationin vivo, making them attractive materials for bone regeneration.
33827063	6	3	from	MPC	976:978	arg1	solution					992:999	Tris-HCl solution	983:999	Tris-HCl solution	983:999	CS-MPCs demonstrated similar degradation ratios relative to MPC in Tris-HCl solution.
33827063	8	4	theme	improved	1213:1220	arg1	properties					1237:1246	improved physiochemical properties	1213:1246	improved physiochemical properties that enhance compatibilityin vitroand bone regenerationin vivo	1213:1309	In conclusion, through CS modification, our novel CS-MPCs have improved physiochemical properties that enhance compatibilityin vitroand bone regenerationin vivo, making them attractive materials for bone regeneration.
33827063	1	5	theme	inorganic	154:162	arg1	cement					116:121	Magnesium phosphate cement	96:121	Magnesium phosphate cement (MPC)	96:127	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	1	5	theme	inorganic	154:162	arg1	filler					169:174	an inorganic bone filler	151:174	an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential	151:294	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	1	6	theme	high	248:251	arg1	strength					261:268	high initial strength	248:268	high initial strength	248:268	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	7	7	theme	enhanced	1097:1104	arg1	formation					1111:1119	enhanced bone formation	1097:1119	enhanced bone formation	1097:1119	CS-MPCs promoted pre-osteoblast cell proliferation, attachment, and differentiationin vitroand enhanced bone formation surrounding implantsin vivo.
33827063	4	8	theme	inducedin	705:713	arg1	responses					729:737	their inducedin vitrocellular responses	699:737	their inducedin vitrocellular responses	699:737	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	4	9	theme	CS-MPCs	687:693	arg1	compositions					623:634	compositions	623:634	compositions	623:634	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	4	9	theme	CS-MPCs	687:693	arg1	properties					673:682	physiochemical properties	658:682	physiochemical properties	658:682	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	4	9	theme	CS-MPCs	687:693	arg1	microstructures					637:651	microstructures	637:651	microstructures	637:651	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	1	10	theme	initial	253:259	arg1	strength					261:268	high initial strength	248:268	high initial strength	248:268	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	2	11	theme	bioactive	463:471	arg1	materials					473:481	bioactive materials	463:481	bioactive materials	463:481	However, the setting time of MPC is so rapid that it makes it difficult to use in practice, and the clinical properties of MPC could be further be improved by adding bioactive materials.
33827063	7	12	theme	bone	1106:1109	arg1	formation					1111:1119	enhanced bone formation	1097:1119	enhanced bone formation	1097:1119	CS-MPCs promoted pre-osteoblast cell proliferation, attachment, and differentiationin vitroand enhanced bone formation surrounding implantsin vivo.
33827063	4	13	dep	compositions	623:634	arg1	The					619:621	The	619:621	The	619:621	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	5	14	theme	more	891:894	arg1	pH					903:904	more neural pH	891:904	more neural pH	891:904	CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC.
33827063	7	15	dep	promoted	1010:1017	arg1	surrounding					1121:1131	surrounding	1121:1131	promoted pre-osteoblast cell proliferation, attachment, and differentiationin vitroand enhanced bone formation surrounding implantsin vivo	1010:1147	CS-MPCs promoted pre-osteoblast cell proliferation, attachment, and differentiationin vitroand enhanced bone formation surrounding implantsin vivo.
33827063	7	16	theme	differentiationin	1070:1086	arg1	vitroand					1088:1095	differentiationin vitroand	1070:1095	differentiationin vitroand	1070:1095	CS-MPCs promoted pre-osteoblast cell proliferation, attachment, and differentiationin vitroand enhanced bone formation surrounding implantsin vivo.
33827063	8	17	theme	vitroand	1277:1284	arg1	bone					1286:1289	compatibilityin vitroand bone	1261:1289	compatibilityin vitroand bone	1261:1289	In conclusion, through CS modification, our novel CS-MPCs have improved physiochemical properties that enhance compatibilityin vitroand bone regenerationin vivo, making them attractive materials for bone regeneration.
33827063	4	18	theme	responses	729:737	arg1	compositions					623:634	compositions	623:634	compositions	623:634	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	4	18	theme	responses	729:737	arg1	properties					673:682	physiochemical properties	658:682	physiochemical properties	658:682	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	4	18	theme	responses	729:737	arg1	microstructures					637:651	microstructures	637:651	microstructures	637:651	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	8	19	theme	compatibilityin	1261:1275	arg1	bone					1286:1289	compatibilityin vitroand bone	1261:1289	compatibilityin vitroand bone	1261:1289	In conclusion, through CS modification, our novel CS-MPCs have improved physiochemical properties that enhance compatibilityin vitroand bone regenerationin vivo, making them attractive materials for bone regeneration.
33827063	1	20	theme	bone	164:167	arg1	cement					116:121	Magnesium phosphate cement	96:121	Magnesium phosphate cement (MPC)	96:127	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	1	20	theme	bone	164:167	arg1	filler					169:174	an inorganic bone filler	151:174	an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential	151:294	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	6	21	theme	degradation	945:955	arg1	ratios					957:962	similar degradation ratios	937:962	similar degradation ratios relative to MPC in Tris-HCl solution	937:999	CS-MPCs demonstrated similar degradation ratios relative to MPC in Tris-HCl solution.
33827063	5	22	theme	compressive	865:875	arg1	strength					877:884	higher compressive strength	858:884	higher compressive strength	858:884	CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC.
33827063	4	23	theme	vitrocellular	715:727	arg1	responses					729:737	their inducedin vitrocellular responses	699:737	their inducedin vitrocellular responses	699:737	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	8	24	theme	CS	1173:1174	arg1	modification					1176:1187	CS modification	1173:1187	CS modification	1173:1187	In conclusion, through CS modification, our novel CS-MPCs have improved physiochemical properties that enhance compatibilityin vitroand bone regenerationin vivo, making them attractive materials for bone regeneration.
33827063	0	25	theme	bioactive	2:10	arg1	cement					32:37	A bioactive magnesium phosphate cement	0:37	A bioactive magnesium phosphate cement	0:37	A bioactive magnesium phosphate cement incorporating chondroitin sulfate for bone regeneration.
33827063	1	26	theme	Magnesium	96:104	arg1	MPC					124:126	MPC	124:126	MPC	124:126	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	1	26	theme	Magnesium	96:104	arg1	cement					116:121	Magnesium phosphate cement	96:121	Magnesium phosphate cement (MPC)	96:127	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	1	26	theme	Magnesium	96:104	arg1	filler					169:174	an inorganic bone filler	151:174	an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential	151:294	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	5	27	theme	lower	829:833	arg1	temperature					845:855	lower hydration temperature	829:855	lower hydration temperature	829:855	CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC.
33827063	6	28	theme	similar	937:943	arg1	ratios					957:962	similar degradation ratios	937:962	similar degradation ratios relative to MPC in Tris-HCl solution	937:999	CS-MPCs demonstrated similar degradation ratios relative to MPC in Tris-HCl solution.
33827063	3	29	theme	sulfate	530:536	arg1	CS-MPCs					559:565	CS-MPCs	559:565	CS-MPCs	559:565	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	3	29	theme	sulfate	530:536	arg1	composites					547:556	novel bioactive chondroitin sulfate (CS)-MPC composites	502:556	novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs)	502:566	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	5	30	theme	hydration	835:843	arg1	temperature					845:855	lower hydration temperature	829:855	lower hydration temperature	829:855	CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC.
33827063	0	31	theme	phosphate	22:30	arg1	cement					32:37	A bioactive magnesium phosphate cement	0:37	A bioactive magnesium phosphate cement	0:37	A bioactive magnesium phosphate cement incorporating chondroitin sulfate for bone regeneration.
33827063	5	32	contain	had	802:804	arg2	temperature					845:855	lower hydration temperature	829:855	lower hydration temperature	829:855	CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC.
33827063	5	32	contain	had	802:804	arg2	strength					877:884	higher compressive strength	858:884	higher compressive strength	858:884	CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC.
33827063	5	32	contain	had	802:804	arg2	time					823:826	a longer setting time	806:826	a longer setting time	806:826	CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC.
33827063	5	32	contain	had	802:804	arg2	pH					903:904	more neural pH	891:904	more neural pH	891:904	CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC.
33827063	5	32	contain	had	802:804	arg1	CS-MPCs					794:800	CS-MPCs	794:800	CS-MPCs	794:800	CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC.
33827063	3	33	theme	novel	502:506	arg1	CS-MPCs					559:565	CS-MPCs	559:565	CS-MPCs	559:565	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	3	33	theme	novel	502:506	arg1	composites					547:556	novel bioactive chondroitin sulfate (CS)-MPC composites	502:556	novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs)	502:566	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	1	34	theme	phosphate	106:114	arg1	MPC					124:126	MPC	124:126	MPC	124:126	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	1	34	theme	phosphate	106:114	arg1	cement					116:121	Magnesium phosphate cement	96:121	Magnesium phosphate cement (MPC)	96:127	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	1	34	theme	phosphate	106:114	arg1	filler					169:174	an inorganic bone filler	151:174	an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential	151:294	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	1	35	theme	osteogenic	275:284	arg1	potential					286:294	osteogenic potential	275:294	osteogenic potential	275:294	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	3	36	theme	different	585:593	arg1	CS					606:607	CS	606:607	CS	606:607	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	3	36	theme	different	585:593	arg1	amounts					595:601	different amounts	585:601	different amounts of CS	585:607	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	3	37	theme	bioactive	508:516	arg1	CS					539:540	CS	539:540	CS	539:540	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	3	37	theme	bioactive	508:516	arg1	sulfate					530:536	bioactive chondroitin sulfate	508:536	novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs)	502:566	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	1	38	theme	favorable	187:195	arg1	biocompatibility					197:212	its favorable biocompatibility	183:212	its favorable biocompatibility	183:212	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	7	39	theme	cell	1034:1037	arg1	proliferation					1039:1051	pre-osteoblast cell proliferation	1019:1051	pre-osteoblast cell proliferation	1019:1051	CS-MPCs promoted pre-osteoblast cell proliferation, attachment, and differentiationin vitroand enhanced bone formation surrounding implantsin vivo.
33827063	4	40	theme	regeneration	754:765	arg1	properties					767:776	andin vivobone regeneration properties	739:776	andin vivobone regeneration properties	739:776	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	5	41	theme	longer	808:813	arg1	time					823:826	a longer setting time	806:826	a longer setting time	806:826	CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC.
33827063	2	42	theme	MPC	420:422	arg1	properties					406:415	the clinical properties	393:415	the clinical properties of MPC	393:422	However, the setting time of MPC is so rapid that it makes it difficult to use in practice, and the clinical properties of MPC could be further be improved by adding bioactive materials.
33827063	6	43	theme	relative	964:971	arg1	ratios					957:962	similar degradation ratios	937:962	similar degradation ratios relative to MPC in Tris-HCl solution	937:999	CS-MPCs demonstrated similar degradation ratios relative to MPC in Tris-HCl solution.
33827063	3	44	theme	-MPC	542:545	arg1	CS-MPCs					559:565	CS-MPCs	559:565	CS-MPCs	559:565	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	3	44	theme	-MPC	542:545	arg1	composites					547:556	novel bioactive chondroitin sulfate (CS)-MPC composites	502:556	novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs)	502:566	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	5	45	theme	setting	815:821	arg1	time					823:826	a longer setting time	806:826	a longer setting time	806:826	CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC.
33827063	8	46	theme	physiochemical	1222:1235	arg1	properties					1237:1246	improved physiochemical properties	1213:1246	improved physiochemical properties that enhance compatibilityin vitroand bone regenerationin vivo	1213:1309	In conclusion, through CS modification, our novel CS-MPCs have improved physiochemical properties that enhance compatibilityin vitroand bone regenerationin vivo, making them attractive materials for bone regeneration.
33827063	2	47	theme	MPC	326:328	arg1	rapid					336:340	rapid	336:340	rapid	336:340	However, the setting time of MPC is so rapid that it makes it difficult to use in practice, and the clinical properties of MPC could be further be improved by adding bioactive materials.
33827063	2	47	theme	MPC	326:328	arg1	time					318:321	the setting time	306:321	the setting time of MPC	306:328	However, the setting time of MPC is so rapid that it makes it difficult to use in practice, and the clinical properties of MPC could be further be improved by adding bioactive materials.
33827063	0	48	theme	chondroitin	53:63	arg1	sulfate					65:71	chondroitin sulfate	53:71	chondroitin sulfate for bone regeneration	53:93	A bioactive magnesium phosphate cement incorporating chondroitin sulfate for bone regeneration.
33827063	7	49	theme	pre-osteoblast	1019:1032	arg1	proliferation					1039:1051	pre-osteoblast cell proliferation	1019:1051	pre-osteoblast cell proliferation	1019:1051	CS-MPCs promoted pre-osteoblast cell proliferation, attachment, and differentiationin vitroand enhanced bone formation surrounding implantsin vivo.
33827063	8	50	contain	have	1208:1211	arg2	properties					1237:1246	improved physiochemical properties	1213:1246	improved physiochemical properties that enhance compatibilityin vitroand bone regenerationin vivo	1213:1309	In conclusion, through CS modification, our novel CS-MPCs have improved physiochemical properties that enhance compatibilityin vitroand bone regenerationin vivo, making them attractive materials for bone regeneration.
33827063	8	50	contain	have	1208:1211	arg1	CS-MPCs					1200:1206	our novel CS-MPCs	1190:1206	our novel CS-MPCs	1190:1206	In conclusion, through CS modification, our novel CS-MPCs have improved physiochemical properties that enhance compatibilityin vitroand bone regenerationin vivo, making them attractive materials for bone regeneration.
33827063	4	51	dep	CS-MPCs	687:693	arg1	properties					767:776	andin vivobone regeneration properties	739:776	andin vivobone regeneration properties	739:776	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	3	52	theme	chondroitin	518:528	arg1	CS					539:540	CS	539:540	CS	539:540	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	3	52	theme	chondroitin	518:528	arg1	sulfate					530:536	bioactive chondroitin sulfate	508:536	novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs)	502:566	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	5	53	theme	neural	896:901	arg1	pH					903:904	more neural pH	891:904	more neural pH	891:904	CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC.
33827063	4	54	theme	vivobone	745:752	arg1	properties					767:776	andin vivobone regeneration properties	739:776	andin vivobone regeneration properties	739:776	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	4	55	theme	physiochemical	658:671	arg1	properties					673:682	physiochemical properties	658:682	physiochemical properties	658:682	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	4	56	theme	andin	739:743	arg1	properties					767:776	andin vivobone regeneration properties	739:776	andin vivobone regeneration properties	739:776	The compositions, microstructures, and physiochemical properties of CS-MPCs and their inducedin vitrocellular responses andin vivobone regeneration properties were evaluated.
33827063	2	57	from	use	372:374	arg1	practice					379:386	practice	379:386	practice	379:386	However, the setting time of MPC is so rapid that it makes it difficult to use in practice, and the clinical properties of MPC could be further be improved by adding bioactive materials.
33827063	2	58	theme	setting	310:316	arg1	rapid					336:340	rapid	336:340	rapid	336:340	However, the setting time of MPC is so rapid that it makes it difficult to use in practice, and the clinical properties of MPC could be further be improved by adding bioactive materials.
33827063	2	58	theme	setting	310:316	arg1	time					318:321	the setting time	306:321	the setting time of MPC	306:328	However, the setting time of MPC is so rapid that it makes it difficult to use in practice, and the clinical properties of MPC could be further be improved by adding bioactive materials.
33827063	6	59	theme	Tris-HCl	983:990	arg1	solution					992:999	Tris-HCl solution	983:999	Tris-HCl solution	983:999	CS-MPCs demonstrated similar degradation ratios relative to MPC in Tris-HCl solution.
33827063	0	60	theme	bone	77:80	arg1	regeneration					82:93	bone regeneration	77:93	bone regeneration	77:93	A bioactive magnesium phosphate cement incorporating chondroitin sulfate for bone regeneration.
33827063	3	61	theme	CS	606:607	arg1	CS					606:607	CS	606:607	CS	606:607	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	3	61	theme	CS	606:607	arg1	amounts					595:601	different amounts	585:601	different amounts of CS	585:607	Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC.
33827063	1	62	theme	rapid	233:237	arg1	setting					239:245	rapid setting	233:245	rapid setting	233:245	Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential.
33827063	7	63	dep	proliferation	1039:1051	arg1	formation					1111:1119	enhanced bone formation	1097:1119	enhanced bone formation	1097:1119	CS-MPCs promoted pre-osteoblast cell proliferation, attachment, and differentiationin vitroand enhanced bone formation surrounding implantsin vivo.
33827063	0	64	theme	magnesium	12:20	arg1	cement					32:37	A bioactive magnesium phosphate cement	0:37	A bioactive magnesium phosphate cement	0:37	A bioactive magnesium phosphate cement incorporating chondroitin sulfate for bone regeneration.
33827063	2	65	theme	clinical	397:404	arg1	properties					406:415	the clinical properties	393:415	the clinical properties of MPC	393:422	However, the setting time of MPC is so rapid that it makes it difficult to use in practice, and the clinical properties of MPC could be further be improved by adding bioactive materials.
34479084	3	0	theme	BC	525:526	arg1	ratio					516:520	a mass ratio	509:520	a mass ratio of BC	509:526	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	0	1	from	passivation	15:25	arg1	soil					30:33	soil	30:33	soil	30:33	Effective lead passivation in soil by bone char/CMC-stabilized FeS composite loading with phosphate-solubilizing bacteria.
34479084	3	2	theme	appropriate	627:637	arg1	environment					647:657	appropriate habitat environment	627:657	appropriate habitat environment for PSB	627:665	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	5	3	theme	simulated	1109:1117	arg1	remediation					1119:1129	simulated remediation	1109:1129	simulated remediation of 10 days	1109:1140	Furthermore, by applying CFB1-P dosage of 3% into Pb-contaminated soil, the labile Pb fractions were reduced from 29.05% to 6.47% after simulated remediation of 10 days, and converted into steady fractions.
34479084	3	4	theme	phosphate-solubilizing	721:742	arg1	PSB					754:756	PSB	754:756	PSB	754:756	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	3	4	theme	phosphate-solubilizing	721:742	arg1	amount					744:749	the phosphate-solubilizing amount	717:749	the phosphate-solubilizing amount of PSB	717:756	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	4	5	theme	maximal	885:891	arg1	uptake					910:915	maximal monolayer Pb(II) uptake	885:915	maximal monolayer Pb(II) uptake of 452.99 mg/g	885:930	Batch experiments showed that the CFB1-P possessed excellent adsorption properties with maximal monolayer Pb(II) uptake of 452.99 mg/g during an extensive pH range of 2.0-6.0.
34479084	7	6	theme	potential	1505:1513	arg1	CFB1-P					1493:1498	CFB1-P	1493:1498	CFB1-P	1493:1498	These results suggested CFB1-P as a potential alternative for efficient remediation of Pb-contaminated soil.
34479084	7	6	theme	potential	1505:1513	arg1	alternative					1515:1525	a potential alternative	1503:1525	a potential alternative for efficient remediation of Pb-contaminated soil	1503:1575	These results suggested CFB1-P as a potential alternative for efficient remediation of Pb-contaminated soil.
34479084	6	7	theme	high	1219:1222	arg1	passivation					1231:1241	high Pb(II) passivation	1219:1241	high Pb(II) passivation	1219:1241	The CFB1-P was demonstrated to achieve high Pb(II) passivation through combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures, for instance, Pb5(PO4)3OH, Pb3(PO4)2 and PbS.
34479084	5	8	theme	%	1016:1016	arg1	dosage					1005:1010	CFB1-P dosage	998:1010	CFB1-P dosage of 3%	998:1016	Furthermore, by applying CFB1-P dosage of 3% into Pb-contaminated soil, the labile Pb fractions were reduced from 29.05% to 6.47% after simulated remediation of 10 days, and converted into steady fractions.
34479084	0	9	with	loading	77:83	arg1	bacteria					113:120	phosphate-solubilizing bacteria	90:120	phosphate-solubilizing bacteria	90:120	Effective lead passivation in soil by bone char/CMC-stabilized FeS composite loading with phosphate-solubilizing bacteria.
34479084	3	10	theme	mass	511:514	arg1	ratio					516:520	a mass ratio	509:520	a mass ratio of BC	509:526	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	6	11	theme	electrostatic	1311:1323	arg1	attraction					1325:1334	electrostatic attraction	1311:1334	electrostatic attraction	1311:1334	The CFB1-P was demonstrated to achieve high Pb(II) passivation through combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures, for instance, Pb5(PO4)3OH, Pb3(PO4)2 and PbS.
34479084	0	12	theme	phosphate-solubilizing	90:111	arg1	bacteria					113:120	phosphate-solubilizing bacteria	90:120	phosphate-solubilizing bacteria	90:120	Effective lead passivation in soil by bone char/CMC-stabilized FeS composite loading with phosphate-solubilizing bacteria.
34479084	3	13	theme	habitat	639:645	arg1	environment					647:657	appropriate habitat environment	627:657	appropriate habitat environment for PSB	627:665	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	6	14	theme	structures	1411:1420	arg1	formation					1378:1386	the formation	1374:1386	the formation of more stable crystal structures	1374:1420	The CFB1-P was demonstrated to achieve high Pb(II) passivation through combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures, for instance, Pb5(PO4)3OH, Pb3(PO4)2 and PbS.
34479084	5	15	theme	29.05	1087:1091	arg1	%					1092:1092	%	1092:1092	%	1092:1092	Furthermore, by applying CFB1-P dosage of 3% into Pb-contaminated soil, the labile Pb fractions were reduced from 29.05% to 6.47% after simulated remediation of 10 days, and converted into steady fractions.
34479084	4	16	theme	adsorption	858:867	arg1	properties					869:878	excellent adsorption properties	848:878	excellent adsorption properties	848:878	Batch experiments showed that the CFB1-P possessed excellent adsorption properties with maximal monolayer Pb(II) uptake of 452.99 mg/g during an extensive pH range of 2.0-6.0.
34479084	2	17	theme	iron	395:398	arg1	FeS					409:411	FeS	409:411	FeS	409:411	Herein, bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation.
34479084	2	17	theme	iron	395:398	arg1	sulfide					400:406	iron sulfide	395:406	iron sulfide (FeS)	395:412	Herein, bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation.
34479084	4	18	theme	pH	952:953	arg1	range					955:959	an extensive pH range	939:959	an extensive pH range of 2.0-6.0	939:970	Batch experiments showed that the CFB1-P possessed excellent adsorption properties with maximal monolayer Pb(II) uptake of 452.99 mg/g during an extensive pH range of 2.0-6.0.
34479084	6	19	theme	biomineralization	1340:1356	arg1	functions					1260:1268	combined functions	1251:1268	combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures,	1251:1421	The CFB1-P was demonstrated to achieve high Pb(II) passivation through combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures, for instance, Pb5(PO4)3OH, Pb3(PO4)2 and PbS.
34479084	1	20	theme	extensive	193:201	arg1	attentions					203:212	extensive attentions	193:212	extensive attentions	193:212	Bioremediation by phosphate-solubilizing bacteria (PSB) has attracted extensive attentions due to its economical and eco-friendly properties for lead (Pb) passivation in soil.
34479084	4	21	theme	excellent	848:856	arg1	properties					869:878	excellent adsorption properties	848:878	excellent adsorption properties	848:878	Batch experiments showed that the CFB1-P possessed excellent adsorption properties with maximal monolayer Pb(II) uptake of 452.99 mg/g during an extensive pH range of 2.0-6.0.
34479084	6	22	theme	precipitation	1282:1294	arg1	functions					1260:1268	combined functions	1251:1268	combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures,	1251:1421	The CFB1-P was demonstrated to achieve high Pb(II) passivation through combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures, for instance, Pb5(PO4)3OH, Pb3(PO4)2 and PbS.
34479084	6	23	theme	stable	1396:1401	arg1	structures					1411:1420	more stable crystal structures	1391:1420	more stable crystal structures	1391:1420	The CFB1-P was demonstrated to achieve high Pb(II) passivation through combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures, for instance, Pb5(PO4)3OH, Pb3(PO4)2 and PbS.
34479084	2	24	theme	BC	386:387	arg1	advantages					372:381	advantages	372:381	advantages of BC	372:387	Herein, bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation.
34479084	0	25	theme	lead	10:13	arg1	passivation					15:25	Effective lead passivation	0:25	Effective lead passivation in soil by bone	0:41	Effective lead passivation in soil by bone char/CMC-stabilized FeS composite loading with phosphate-solubilizing bacteria.
34479084	2	26	contain	carrying	363:370	arg2	advantages					372:381	advantages	372:381	advantages of BC	372:387	Herein, bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation.
34479084	2	26	contain	carrying	363:370	arg1	composite					344:352	biochemical composite	332:352	biochemical composite (CFB1-P) carrying advantages of BC	332:387	Herein, bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation.
34479084	2	26	contain	carrying	363:370	arg1	CFB1-P					355:360	CFB1-P	355:360	CFB1-P	355:360	Herein, bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation.
34479084	7	27	theme	soil	1572:1575	arg1	remediation					1541:1551	efficient remediation	1531:1551	efficient remediation of Pb-contaminated soil	1531:1575	These results suggested CFB1-P as a potential alternative for efficient remediation of Pb-contaminated soil.
34479084	0	28	theme	Effective	0:8	arg1	passivation					15:25	Effective lead passivation	0:25	Effective lead passivation in soil by bone	0:41	Effective lead passivation in soil by bone char/CMC-stabilized FeS composite loading with phosphate-solubilizing bacteria.
34479084	6	29	theme	chemical	1273:1280	arg1	precipitation					1282:1294	chemical precipitation	1273:1294	chemical precipitation	1273:1294	The CFB1-P was demonstrated to achieve high Pb(II) passivation through combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures, for instance, Pb5(PO4)3OH, Pb3(PO4)2 and PbS.
34479084	5	30	theme	labile	1049:1054	arg1	fractions					1059:1067	the labile Pb fractions	1045:1067	the labile Pb fractions	1045:1067	Furthermore, by applying CFB1-P dosage of 3% into Pb-contaminated soil, the labile Pb fractions were reduced from 29.05% to 6.47% after simulated remediation of 10 days, and converted into steady fractions.
34479084	1	31	from	passivation	278:288	arg1	soil					293:296	soil	293:296	soil	293:296	Bioremediation by phosphate-solubilizing bacteria (PSB) has attracted extensive attentions due to its economical and eco-friendly properties for lead (Pb) passivation in soil.
34479084	6	32	theme	Pb	1224:1225	arg1	passivation					1231:1241	high Pb(II) passivation	1219:1241	high Pb(II) passivation	1219:1241	The CFB1-P was demonstrated to achieve high Pb(II) passivation through combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures, for instance, Pb5(PO4)3OH, Pb3(PO4)2 and PbS.
34479084	4	33	theme	452.99 mg/g	920:930	arg1	uptake					910:915	maximal monolayer Pb(II) uptake	885:915	maximal monolayer Pb(II) uptake of 452.99 mg/g	885:930	Batch experiments showed that the CFB1-P possessed excellent adsorption properties with maximal monolayer Pb(II) uptake of 452.99 mg/g during an extensive pH range of 2.0-6.0.
34479084	5	34	theme	Pb	1056:1057	arg1	fractions					1059:1067	the labile Pb fractions	1045:1067	the labile Pb fractions	1045:1067	Furthermore, by applying CFB1-P dosage of 3% into Pb-contaminated soil, the labile Pb fractions were reduced from 29.05% to 6.47% after simulated remediation of 10 days, and converted into steady fractions.
34479084	2	35	theme	bone	307:310	arg1	char					312:315	bone char	307:315	bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC)	307:446	Herein, bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation.
34479084	2	35	theme	bone	307:310	arg1	BC					318:319	BC	318:319	BC	318:319	Herein, bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation.
34479084	5	36	theme	steady	1162:1167	arg1	fractions					1169:1177	steady fractions	1162:1177	steady fractions	1162:1177	Furthermore, by applying CFB1-P dosage of 3% into Pb-contaminated soil, the labile Pb fractions were reduced from 29.05% to 6.47% after simulated remediation of 10 days, and converted into steady fractions.
34479084	1	37	theme	economical	225:234	arg1	properties					253:262	its economical and eco-friendly properties	221:262	its economical and eco-friendly properties	221:262	Bioremediation by phosphate-solubilizing bacteria (PSB) has attracted extensive attentions due to its economical and eco-friendly properties for lead (Pb) passivation in soil.
34479084	1	38	theme	phosphate-solubilizing	141:162	arg1	bacteria					164:171	phosphate-solubilizing bacteria	141:171	phosphate-solubilizing bacteria (PSB)	141:177	Bioremediation by phosphate-solubilizing bacteria (PSB) has attracted extensive attentions due to its economical and eco-friendly properties for lead (Pb) passivation in soil.
34479084	1	38	theme	phosphate-solubilizing	141:162	arg1	PSB					174:176	PSB	174:176	PSB	174:176	Bioremediation by phosphate-solubilizing bacteria (PSB) has attracted extensive attentions due to its economical and eco-friendly properties for lead (Pb) passivation in soil.
34479084	6	39	theme	complexation	1297:1308	arg1	functions					1260:1268	combined functions	1251:1268	combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures,	1251:1421	The CFB1-P was demonstrated to achieve high Pb(II) passivation through combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures, for instance, Pb5(PO4)3OH, Pb3(PO4)2 and PbS.
34479084	3	40	dep	toxicity	692:699	arg1	II					688:689	II	688:689	II	688:689	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	4	41	theme	Pb	903:904	arg1	uptake					910:915	maximal monolayer Pb(II) uptake	885:915	maximal monolayer Pb(II) uptake of 452.99 mg/g	885:930	Batch experiments showed that the CFB1-P possessed excellent adsorption properties with maximal monolayer Pb(II) uptake of 452.99 mg/g during an extensive pH range of 2.0-6.0.
34479084	5	42	dep	%	1092:1092	arg1	to					1094:1095	to	1094:1095	to	1094:1095	Furthermore, by applying CFB1-P dosage of 3% into Pb-contaminated soil, the labile Pb fractions were reduced from 29.05% to 6.47% after simulated remediation of 10 days, and converted into steady fractions.
34479084	6	43	theme	combined	1251:1258	arg1	functions					1260:1268	combined functions	1251:1268	combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures,	1251:1421	The CFB1-P was demonstrated to achieve high Pb(II) passivation through combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures, for instance, Pb5(PO4)3OH, Pb3(PO4)2 and PbS.
34479084	3	44	theme	passivation	559:569	arg1	efficiency					571:580	high passivation efficiency	554:580	high passivation efficiency (65.47%)	554:589	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	3	44	theme	passivation	559:569	arg1	%					588:588	65.47%	583:588	65.47%	583:588	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	5	45	theme	6.47	1097:1100	arg1	%					1092:1092	%	1092:1092	%	1092:1092	Furthermore, by applying CFB1-P dosage of 3% into Pb-contaminated soil, the labile Pb fractions were reduced from 29.05% to 6.47% after simulated remediation of 10 days, and converted into steady fractions.
34479084	1	46	theme	eco-friendly	240:251	arg1	properties					253:262	its economical and eco-friendly properties	221:262	its economical and eco-friendly properties	221:262	Bioremediation by phosphate-solubilizing bacteria (PSB) has attracted extensive attentions due to its economical and eco-friendly properties for lead (Pb) passivation in soil.
34479084	5	47	theme	Pb-contaminated	1023:1037	arg1	soil					1039:1042	Pb-contaminated soil	1023:1042	Pb-contaminated soil	1023:1042	Furthermore, by applying CFB1-P dosage of 3% into Pb-contaminated soil, the labile Pb fractions were reduced from 29.05% to 6.47% after simulated remediation of 10 days, and converted into steady fractions.
34479084	2	48	theme	Pb	476:477	arg1	passivation					479:489	Pb passivation	476:489	Pb passivation	476:489	Herein, bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation.
34479084	2	49	theme	carboxymethyl	418:430	arg1	cellulose					432:440	carboxymethyl cellulose	418:440	carboxymethyl cellulose (CMC)	418:446	Herein, bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation.
34479084	2	49	theme	carboxymethyl	418:430	arg1	CMC					443:445	CMC	443:445	CMC	443:445	Herein, bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation.
34479084	5	50	theme	CFB1-P	998:1003	arg1	dosage					1005:1010	CFB1-P dosage	998:1010	CFB1-P dosage of 3%	998:1016	Furthermore, by applying CFB1-P dosage of 3% into Pb-contaminated soil, the labile Pb fractions were reduced from 29.05% to 6.47% after simulated remediation of 10 days, and converted into steady fractions.
34479084	2	51	theme	biochemical	332:342	arg1	CFB1-P					355:360	CFB1-P	355:360	CFB1-P	355:360	Herein, bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation.
34479084	2	51	theme	biochemical	332:342	arg1	composite					344:352	biochemical composite	332:352	biochemical composite (CFB1-P) carrying advantages of BC	332:387	Herein, bone char (BC) supported biochemical composite (CFB1-P) carrying advantages of BC, PSB, iron sulfide (FeS) and carboxymethyl cellulose (CMC) was designed and applied to Pb passivation.
34479084	4	52	theme	2.0-6.0	964:970	arg1	range					955:959	an extensive pH range	939:959	an extensive pH range of 2.0-6.0	939:970	Batch experiments showed that the CFB1-P possessed excellent adsorption properties with maximal monolayer Pb(II) uptake of 452.99 mg/g during an extensive pH range of 2.0-6.0.
34479084	3	53	theme	Pb	685:686	arg1	toxicity					692:699	Pb(II) toxicity	685:699	Pb(II) toxicity	685:699	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	4	54	theme	Batch	797:801	arg1	experiments					803:813	Batch experiments	797:813	Batch experiments	797:813	Batch experiments showed that the CFB1-P possessed excellent adsorption properties with maximal monolayer Pb(II) uptake of 452.99 mg/g during an extensive pH range of 2.0-6.0.
34479084	7	55	theme	Pb-contaminated	1556:1570	arg1	soil					1572:1575	Pb-contaminated soil	1556:1575	Pb-contaminated soil	1556:1575	These results suggested CFB1-P as a potential alternative for efficient remediation of Pb-contaminated soil.
34479084	4	56	contain	possessed	838:846	arg1	CFB1-P					831:836	the CFB1-P	827:836	the CFB1-P	827:836	Batch experiments showed that the CFB1-P possessed excellent adsorption properties with maximal monolayer Pb(II) uptake of 452.99 mg/g during an extensive pH range of 2.0-6.0.
34479084	4	56	contain	possessed	838:846	arg2	properties					869:878	excellent adsorption properties	848:878	excellent adsorption properties	848:878	Batch experiments showed that the CFB1-P possessed excellent adsorption properties with maximal monolayer Pb(II) uptake of 452.99 mg/g during an extensive pH range of 2.0-6.0.
34479084	3	57	dep	composite	496:504	arg1	CMC					528:530	CMC	528:530	The composite at a mass ratio of BC:CMC:FeS = 1:1:1	492:542	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	3	57	dep	composite	496:504	arg1	= 1:1:1					536:542	FeS = 1:1:1	532:542	The composite at a mass ratio of BC:CMC:FeS = 1:1:1	492:542	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	5	58	theme	days	1137:1140	arg1	remediation					1119:1129	simulated remediation	1109:1129	simulated remediation of 10 days	1109:1140	Furthermore, by applying CFB1-P dosage of 3% into Pb-contaminated soil, the labile Pb fractions were reduced from 29.05% to 6.47% after simulated remediation of 10 days, and converted into steady fractions.
34479084	6	59	theme	Pb5	1437:1439	arg1	3OH					1445:1447	Pb5(PO4)3OH	1437:1447	Pb5(PO4)3OH	1437:1447	The CFB1-P was demonstrated to achieve high Pb(II) passivation through combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures, for instance, Pb5(PO4)3OH, Pb3(PO4)2 and PbS.
34479084	3	60	theme	high	554:557	arg1	efficiency					571:580	high passivation efficiency	554:580	high passivation efficiency (65.47%)	554:589	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	3	60	theme	high	554:557	arg1	%					588:588	65.47%	583:588	65.47%	583:588	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	3	61	from	ratio	516:520	arg1	composite					496:504	The composite	492:504	The composite at a mass ratio of BC:CMC:FeS = 1:1:1	492:542	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	0	62	theme	composite	67:75	arg1	loading					77:83	FeS composite loading	63:83	FeS composite loading with phosphate-solubilizing bacteria	63:120	Effective lead passivation in soil by bone char/CMC-stabilized FeS composite loading with phosphate-solubilizing bacteria.
34479084	3	63	theme	passivating	777:787	arg1	II					792:793	II	792:793	II	792:793	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	3	63	theme	passivating	777:787	arg1	Pb					789:790	passivating Pb	777:790	passivating Pb(II)	777:794	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	3	64	theme	FeS	532:534	arg1	= 1:1:1					536:542	FeS = 1:1:1	532:542	The composite at a mass ratio of BC:CMC:FeS = 1:1:1	492:542	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	6	65	theme	attraction	1325:1334	arg1	functions					1260:1268	combined functions	1251:1268	combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures,	1251:1421	The CFB1-P was demonstrated to achieve high Pb(II) passivation through combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures, for instance, Pb5(PO4)3OH, Pb3(PO4)2 and PbS.
34479084	3	66	theme	PSB	754:756	arg1	PSB					754:756	PSB	754:756	PSB	754:756	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	3	66	theme	PSB	754:756	arg1	amount					744:749	the phosphate-solubilizing amount	717:749	the phosphate-solubilizing amount of PSB	717:756	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	1	67	theme	lead	268:271	arg1	passivation					278:288	lead (Pb) passivation	268:288	lead (Pb) passivation in soil	268:296	Bioremediation by phosphate-solubilizing bacteria (PSB) has attracted extensive attentions due to its economical and eco-friendly properties for lead (Pb) passivation in soil.
34479084	0	68	theme	FeS	63:65	arg1	loading					77:83	FeS composite loading	63:83	FeS composite loading with phosphate-solubilizing bacteria	63:120	Effective lead passivation in soil by bone char/CMC-stabilized FeS composite loading with phosphate-solubilizing bacteria.
34479084	4	69	theme	monolayer	893:901	arg1	uptake					910:915	maximal monolayer Pb(II) uptake	885:915	maximal monolayer Pb(II) uptake of 452.99 mg/g	885:930	Batch experiments showed that the CFB1-P possessed excellent adsorption properties with maximal monolayer Pb(II) uptake of 452.99 mg/g during an extensive pH range of 2.0-6.0.
34479084	7	70	theme	efficient	1531:1539	arg1	remediation					1541:1551	efficient remediation	1531:1551	efficient remediation of Pb-contaminated soil	1531:1575	These results suggested CFB1-P as a potential alternative for efficient remediation of Pb-contaminated soil.
34479084	6	71	theme	crystal	1403:1409	arg1	structures					1411:1420	more stable crystal structures	1391:1420	more stable crystal structures	1391:1420	The CFB1-P was demonstrated to achieve high Pb(II) passivation through combined functions of chemical precipitation, complexation, electrostatic attraction and biomineralization, accompanied by the formation of more stable crystal structures, for instance, Pb5(PO4)3OH, Pb3(PO4)2 and PbS.
34479084	4	72	theme	extensive	942:950	arg1	range					955:959	an extensive pH range	939:959	an extensive pH range of 2.0-6.0	939:970	Batch experiments showed that the CFB1-P possessed excellent adsorption properties with maximal monolayer Pb(II) uptake of 452.99 mg/g during an extensive pH range of 2.0-6.0.
34479084	3	73	contain	possessed	544:552	arg1	composite					496:504	The composite	492:504	The composite at a mass ratio of BC:CMC:FeS = 1:1:1	492:542	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	3	73	contain	possessed	544:552	arg2	%					588:588	65.47%	583:588	65.47%	583:588	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34479084	3	73	contain	possessed	544:552	arg2	efficiency					571:580	high passivation efficiency	554:580	high passivation efficiency (65.47%)	554:589	The composite at a mass ratio of BC:CMC:FeS = 1:1:1 possessed high passivation efficiency (65.47%), and has been demonstrated to offer appropriate habitat environment for PSB to defend against Pb(II) toxicity, thus enhancing the phosphate-solubilizing amount of PSB to 140.72 mg/L for passivating Pb(II).
34029583	2	0	theme	mgF-	424:427	arg1	kg-1					429:432	4650 mgF- kg-1	419:432	4650 mgF- kg-1	419:432	The prepared AGO@CS composite beads possess enriched defluoridation capacity (DC) of 4650 mgF- kg-1.
34029583	3	1	theme	Batch	435:439	arg1	method					441:446	Batch method	435:446	Batch method	435:446	Batch method was used to optimize the maximum DC of AGO@CS composite beads.
34029583	6	2	theme	beads	898:902	arg1	mechanism					878:886	The possible defluoridation mechanism	850:886	The possible defluoridation mechanism of AGO@CS beads	850:902	The possible defluoridation mechanism of AGO@CS beads was mostly proposed that electrostatic attraction.
34029583	0	3	theme	hybrid	75:80	arg1	beads					82:86	chitosan hybrid beads	66:86	chitosan hybrid beads for defluoridation of water	66:114	Design and synthesis of amine grafted graphene oxide encapsulated chitosan hybrid beads for defluoridation of water.
34029583	1	4	dep	chitosan	237:244	arg1	AGO					222:224	AGO	222:224	AGO	222:224	The promising adsorbent like graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads was efficiently prepared for defluoridation studies.
34029583	2	5	contain	possess	370:376	arg2	DC					412:413	DC	412:413	DC	412:413	The prepared AGO@CS composite beads possess enriched defluoridation capacity (DC) of 4650 mgF- kg-1.
34029583	2	5	contain	possess	370:376	arg2	capacity					402:409	enriched defluoridation capacity	378:409	enriched defluoridation capacity (DC) of 4650 mgF- kg-1	378:432	The prepared AGO@CS composite beads possess enriched defluoridation capacity (DC) of 4650 mgF- kg-1.
34029583	2	5	contain	possess	370:376	arg1	beads					364:368	The prepared AGO@CS composite beads	334:368	The prepared AGO@CS composite beads	334:368	The prepared AGO@CS composite beads possess enriched defluoridation capacity (DC) of 4650 mgF- kg-1.
34029583	5	6	theme	adsorption	793:802	arg1	isotherms					804:812	adsorption isotherms	793:812	adsorption isotherms	793:812	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions were assessed with adsorption isotherms, kinetic and thermodynamic studies.
34029583	6	7	theme	CS	895:896	arg1	beads					898:902	AGO@CS beads	891:902	AGO@CS beads	891:902	The possible defluoridation mechanism of AGO@CS beads was mostly proposed that electrostatic attraction.
34029583	7	8	theme	CS	1010:1011	arg1	beads					1013:1017	AGO@CS beads	1006:1017	AGO@CS beads	1006:1017	The reusability and field investigation results of AGO@CS beads shows they are regenerable and applicable at field circumstances.
34029583	4	9	theme	TGA	650:652	arg1	techniques					607:616	numerous instrumental techniques	585:616	numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation	585:666	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	9	theme	TGA	650:652	arg1	investigation					654:666	TGA investigation	650:666	TGA investigation	650:666	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	6	10	theme	@	894:894	arg1	beads					898:902	AGO@CS beads	891:902	AGO@CS beads	891:902	The possible defluoridation mechanism of AGO@CS beads was mostly proposed that electrostatic attraction.
34029583	5	11	theme	thermodynamic	827:839	arg1	studies					841:847	kinetic and thermodynamic studies	815:847	kinetic and thermodynamic studies	815:847	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions were assessed with adsorption isotherms, kinetic and thermodynamic studies.
34029583	4	12	dep	techniques	607:616	arg1	FTIR					624:627	FTIR	624:627	FTIR	624:627	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	12	dep	techniques	607:616	arg1	Raman					630:634	Raman	630:634	Raman	630:634	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	12	dep	techniques	607:616	arg1	investigation					654:666	TGA investigation	650:666	TGA investigation	650:666	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	12	dep	techniques	607:616	arg1	techniques					607:616	numerous instrumental techniques	585:616	numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation	585:666	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	12	dep	techniques	607:616	arg1	viz.					618:621	viz.	618:621	viz.	618:621	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	12	dep	techniques	607:616	arg1	XPS					637:639	XPS	637:639	XPS	637:639	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	12	dep	techniques	607:616	arg1	SEM					642:644	SEM	642:644	SEM	642:644	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	3	13	theme	maximum	473:479	arg1	DC					481:482	the maximum DC	469:482	the maximum DC of AGO@CS composite beads	469:508	Batch method was used to optimize the maximum DC of AGO@CS composite beads.
34029583	1	14	theme	decorated	227:235	arg1	chitosan					237:244	amine functionalized graphene oxide (AGO) decorated chitosan	185:244	amine functionalized graphene oxide (AGO) decorated chitosan	185:244	The promising adsorbent like graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads was efficiently prepared for defluoridation studies.
34029583	0	15	theme	water	110:114	arg1	defluoridation					92:105	defluoridation	92:105	defluoridation of water	92:114	Design and synthesis of amine grafted graphene oxide encapsulated chitosan hybrid beads for defluoridation of water.
34029583	5	16	theme	various	743:749	arg1	conditions					763:772	various temperature conditions	743:772	various temperature conditions	743:772	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions were assessed with adsorption isotherms, kinetic and thermodynamic studies.
34029583	1	17	theme	defluoridation	310:323	arg1	studies					325:331	defluoridation studies	310:331	defluoridation studies	310:331	The promising adsorbent like graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads was efficiently prepared for defluoridation studies.
34029583	7	18	theme	@	1009:1009	arg1	CS					1010:1011	@CS	1009:1011	AGO@CS beads	1006:1017	The reusability and field investigation results of AGO@CS beads shows they are regenerable and applicable at field circumstances.
34029583	5	19	theme	@	699:699	arg1	beads					713:717	AGO@CS composite beads	696:717	AGO@CS composite beads	696:717	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions were assessed with adsorption isotherms, kinetic and thermodynamic studies.
34029583	2	20	theme	prepared	338:345	arg1	beads					364:368	The prepared AGO@CS composite beads	334:368	The prepared AGO@CS composite beads	334:368	The prepared AGO@CS composite beads possess enriched defluoridation capacity (DC) of 4650 mgF- kg-1.
34029583	7	21	dep	reusability	959:969	arg1	results					995:1001	results	995:1001	results	995:1001	The reusability and field investigation results of AGO@CS beads shows they are regenerable and applicable at field circumstances.
34029583	7	21	dep	reusability	959:969	arg1	The					955:957	The	955:957	The	955:957	The reusability and field investigation results of AGO@CS beads shows they are regenerable and applicable at field circumstances.
34029583	1	22	dep	oxide	155:159	arg1	GO					162:163	GO	162:163	GO	162:163	The promising adsorbent like graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads was efficiently prepared for defluoridation studies.
34029583	1	22	dep	oxide	155:159	arg1	beads					275:279	composite beads	265:279	graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads	146:279	The promising adsorbent like graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads was efficiently prepared for defluoridation studies.
34029583	5	23	theme	temperature	751:761	arg1	conditions					763:772	various temperature conditions	743:772	various temperature conditions	743:772	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions were assessed with adsorption isotherms, kinetic and thermodynamic studies.
34029583	2	24	theme	defluoridation	387:400	arg1	DC					412:413	DC	412:413	DC	412:413	The prepared AGO@CS composite beads possess enriched defluoridation capacity (DC) of 4650 mgF- kg-1.
34029583	2	24	theme	defluoridation	387:400	arg1	capacity					402:409	enriched defluoridation capacity	378:409	enriched defluoridation capacity (DC) of 4650 mgF- kg-1	378:432	The prepared AGO@CS composite beads possess enriched defluoridation capacity (DC) of 4650 mgF- kg-1.
34029583	3	25	theme	@	490:490	arg1	beads					504:508	AGO@CS composite beads	487:508	AGO@CS composite beads	487:508	Batch method was used to optimize the maximum DC of AGO@CS composite beads.
34029583	5	26	from	conditions	763:772	arg1	removal					732:738	fluoride removal	723:738	fluoride removal at various temperature conditions	723:772	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions were assessed with adsorption isotherms, kinetic and thermodynamic studies.
34029583	2	27	theme	enriched	378:385	arg1	DC					412:413	DC	412:413	DC	412:413	The prepared AGO@CS composite beads possess enriched defluoridation capacity (DC) of 4650 mgF- kg-1.
34029583	2	27	theme	enriched	378:385	arg1	capacity					402:409	enriched defluoridation capacity	378:409	enriched defluoridation capacity (DC) of 4650 mgF- kg-1	378:432	The prepared AGO@CS composite beads possess enriched defluoridation capacity (DC) of 4650 mgF- kg-1.
34029583	5	28	theme	fluoride	723:730	arg1	removal					732:738	fluoride removal	723:738	fluoride removal at various temperature conditions	723:772	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions were assessed with adsorption isotherms, kinetic and thermodynamic studies.
34029583	7	29	theme	field	975:979	arg1	investigation					981:993	field investigation	975:993	field investigation	975:993	The reusability and field investigation results of AGO@CS beads shows they are regenerable and applicable at field circumstances.
34029583	4	30	theme	@	548:548	arg1	beads					562:566	AGO@CS composite beads	545:566	AGO@CS composite beads	545:566	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	5	31	theme	composite	703:711	arg1	beads					713:717	AGO@CS composite beads	696:717	AGO@CS composite beads	696:717	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions were assessed with adsorption isotherms, kinetic and thermodynamic studies.
34029583	6	32	theme	defluoridation	863:876	arg1	mechanism					878:886	The possible defluoridation mechanism	850:886	The possible defluoridation mechanism of AGO@CS beads	850:902	The possible defluoridation mechanism of AGO@CS beads was mostly proposed that electrostatic attraction.
34029583	4	33	theme	physicochemical	515:529	arg1	properties					531:540	The physicochemical properties	511:540	The physicochemical properties of AGO@CS composite beads	511:566	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	5	34	dep	assessed	779:786	arg1	studies					841:847	kinetic and thermodynamic studies	815:847	kinetic and thermodynamic studies	815:847	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions were assessed with adsorption isotherms, kinetic and thermodynamic studies.
34029583	2	35	theme	composite	354:362	arg1	beads					364:368	The prepared AGO@CS composite beads	334:368	The prepared AGO@CS composite beads	334:368	The prepared AGO@CS composite beads possess enriched defluoridation capacity (DC) of 4650 mgF- kg-1.
34029583	0	36	theme	grafted	30:36	arg1	oxide					47:51	amine grafted graphene oxide	24:51	amine grafted graphene oxide	24:51	Design and synthesis of amine grafted graphene oxide encapsulated chitosan hybrid beads for defluoridation of water.
34029583	6	37	theme	possible	854:861	arg1	mechanism					878:886	The possible defluoridation mechanism	850:886	The possible defluoridation mechanism of AGO@CS beads	850:902	The possible defluoridation mechanism of AGO@CS beads was mostly proposed that electrostatic attraction.
34029583	4	38	theme	composite	552:560	arg1	beads					562:566	AGO@CS composite beads	545:566	AGO@CS composite beads	545:566	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	3	39	theme	beads	504:508	arg1	DC					481:482	the maximum DC	469:482	the maximum DC of AGO@CS composite beads	469:508	Batch method was used to optimize the maximum DC of AGO@CS composite beads.
34029583	2	40	theme	CS	351:352	arg1	beads					364:368	The prepared AGO@CS composite beads	334:368	The prepared AGO@CS composite beads	334:368	The prepared AGO@CS composite beads possess enriched defluoridation capacity (DC) of 4650 mgF- kg-1.
34029583	0	41	theme	amine	24:28	arg1	oxide					47:51	amine grafted graphene oxide	24:51	amine grafted graphene oxide	24:51	Design and synthesis of amine grafted graphene oxide encapsulated chitosan hybrid beads for defluoridation of water.
34029583	5	42	theme	experimental	673:684	arg1	values					686:691	The experimental values	669:691	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions	669:772	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions were assessed with adsorption isotherms, kinetic and thermodynamic studies.
34029583	5	43	theme	CS	700:701	arg1	beads					713:717	AGO@CS composite beads	696:717	AGO@CS composite beads	696:717	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions were assessed with adsorption isotherms, kinetic and thermodynamic studies.
34029583	4	44	theme	CS	549:550	arg1	beads					562:566	AGO@CS composite beads	545:566	AGO@CS composite beads	545:566	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	0	45	theme	oxide	47:51	arg1	synthesis					11:19	synthesis	11:19	synthesis	11:19	Design and synthesis of amine grafted graphene oxide encapsulated chitosan hybrid beads for defluoridation of water.
34029583	0	45	theme	oxide	47:51	arg1	Design					0:5	Design	0:5	Design	0:5	Design and synthesis of amine grafted graphene oxide encapsulated chitosan hybrid beads for defluoridation of water.
34029583	3	46	theme	CS	491:492	arg1	beads					504:508	AGO@CS composite beads	487:508	AGO@CS composite beads	487:508	Batch method was used to optimize the maximum DC of AGO@CS composite beads.
34029583	7	47	from	circumstances	1070:1082	arg1	regenerable					1034:1044	regenerable	1034:1044	regenerable	1034:1044	The reusability and field investigation results of AGO@CS beads shows they are regenerable and applicable at field circumstances.
34029583	0	48	theme	graphene	38:45	arg1	oxide					47:51	amine grafted graphene oxide	24:51	amine grafted graphene oxide	24:51	Design and synthesis of amine grafted graphene oxide encapsulated chitosan hybrid beads for defluoridation of water.
34029583	1	49	theme	@	261:261	arg1	CS					262:263	@CS	261:263	graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads	146:279	The promising adsorbent like graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads was efficiently prepared for defluoridation studies.
34029583	3	50	theme	composite	494:502	arg1	beads					504:508	AGO@CS composite beads	487:508	AGO@CS composite beads	487:508	Batch method was used to optimize the maximum DC of AGO@CS composite beads.
34029583	5	51	theme	kinetic	815:821	arg1	studies					841:847	kinetic and thermodynamic studies	815:847	kinetic and thermodynamic studies	815:847	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions were assessed with adsorption isotherms, kinetic and thermodynamic studies.
34029583	1	52	theme	amine	185:189	arg1	chitosan					237:244	amine functionalized graphene oxide (AGO) decorated chitosan	185:244	amine functionalized graphene oxide (AGO) decorated chitosan	185:244	The promising adsorbent like graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads was efficiently prepared for defluoridation studies.
34029583	4	53	theme	numerous	585:592	arg1	FTIR					624:627	FTIR	624:627	FTIR	624:627	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	53	theme	numerous	585:592	arg1	Raman					630:634	Raman	630:634	Raman	630:634	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	53	theme	numerous	585:592	arg1	investigation					654:666	TGA investigation	650:666	TGA investigation	650:666	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	53	theme	numerous	585:592	arg1	techniques					607:616	numerous instrumental techniques	585:616	numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation	585:666	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	53	theme	numerous	585:592	arg1	viz.					618:621	viz.	618:621	viz.	618:621	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	53	theme	numerous	585:592	arg1	XPS					637:639	XPS	637:639	XPS	637:639	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	53	theme	numerous	585:592	arg1	SEM					642:644	SEM	642:644	SEM	642:644	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	1	54	theme	functionalized	191:204	arg1	chitosan					237:244	amine functionalized graphene oxide (AGO) decorated chitosan	185:244	amine functionalized graphene oxide (AGO) decorated chitosan	185:244	The promising adsorbent like graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads was efficiently prepared for defluoridation studies.
34029583	0	55	theme	chitosan	66:73	arg1	beads					82:86	chitosan hybrid beads	66:86	chitosan hybrid beads for defluoridation of water	66:114	Design and synthesis of amine grafted graphene oxide encapsulated chitosan hybrid beads for defluoridation of water.
34029583	6	56	theme	electrostatic	929:941	arg1	attraction					943:952	electrostatic attraction	929:952	electrostatic attraction	929:952	The possible defluoridation mechanism of AGO@CS beads was mostly proposed that electrostatic attraction.
34029583	3	57	used	used	452:455	arg2	method					441:446	Batch method	435:446	Batch method	435:446	Batch method was used to optimize the maximum DC of AGO@CS composite beads.
34029583	5	58	theme	beads	713:717	arg1	values					686:691	The experimental values	669:691	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions	669:772	The experimental values of AGO@CS composite beads for fluoride removal at various temperature conditions were assessed with adsorption isotherms, kinetic and thermodynamic studies.
34029583	4	59	theme	instrumental	594:605	arg1	FTIR					624:627	FTIR	624:627	FTIR	624:627	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	59	theme	instrumental	594:605	arg1	Raman					630:634	Raman	630:634	Raman	630:634	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	59	theme	instrumental	594:605	arg1	investigation					654:666	TGA investigation	650:666	TGA investigation	650:666	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	59	theme	instrumental	594:605	arg1	techniques					607:616	numerous instrumental techniques	585:616	numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation	585:666	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	59	theme	instrumental	594:605	arg1	viz.					618:621	viz.	618:621	viz.	618:621	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	59	theme	instrumental	594:605	arg1	XPS					637:639	XPS	637:639	XPS	637:639	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	59	theme	instrumental	594:605	arg1	SEM					642:644	SEM	642:644	SEM	642:644	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	4	60	theme	beads	562:566	arg1	properties					531:540	The physicochemical properties	511:540	The physicochemical properties of AGO@CS composite beads	511:566	The physicochemical properties of AGO@CS composite beads were explored by numerous instrumental techniques viz., FTIR, Raman, XPS, SEM and TGA investigation.
34029583	1	61	theme	graphene	206:213	arg1	chitosan					237:244	amine functionalized graphene oxide (AGO) decorated chitosan	185:244	amine functionalized graphene oxide (AGO) decorated chitosan	185:244	The promising adsorbent like graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads was efficiently prepared for defluoridation studies.
34029583	2	62	theme	kg-1	429:432	arg1	DC					412:413	DC	412:413	DC	412:413	The prepared AGO@CS composite beads possess enriched defluoridation capacity (DC) of 4650 mgF- kg-1.
34029583	2	62	theme	kg-1	429:432	arg1	capacity					402:409	enriched defluoridation capacity	378:409	enriched defluoridation capacity (DC) of 4650 mgF- kg-1	378:432	The prepared AGO@CS composite beads possess enriched defluoridation capacity (DC) of 4650 mgF- kg-1.
34029583	1	63	theme	composite	265:273	arg1	beads					275:279	composite beads	265:279	graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads	146:279	The promising adsorbent like graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads was efficiently prepared for defluoridation studies.
34029583	7	64	theme	field	1064:1068	arg1	circumstances					1070:1082	field circumstances	1064:1082	field circumstances	1064:1082	The reusability and field investigation results of AGO@CS beads shows they are regenerable and applicable at field circumstances.
34029583	7	65	theme	beads	1013:1017	arg1	reusability					959:969	reusability	959:969	reusability	959:969	The reusability and field investigation results of AGO@CS beads shows they are regenerable and applicable at field circumstances.
34029583	7	65	theme	beads	1013:1017	arg1	investigation					981:993	field investigation	975:993	field investigation	975:993	The reusability and field investigation results of AGO@CS beads shows they are regenerable and applicable at field circumstances.
34029583	1	66	theme	graphene	146:153	arg1	CS					247:248	CS	247:248	CS	247:248	The promising adsorbent like graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads was efficiently prepared for defluoridation studies.
34029583	1	66	theme	graphene	146:153	arg1	oxide					155:159	graphene oxide	146:159	graphene oxide (GO)	146:164	The promising adsorbent like graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads was efficiently prepared for defluoridation studies.
34029583	1	67	theme	oxide	215:219	arg1	chitosan					237:244	amine functionalized graphene oxide (AGO) decorated chitosan	185:244	amine functionalized graphene oxide (AGO) decorated chitosan	185:244	The promising adsorbent like graphene oxide (GO), chitosan (CS) and amine functionalized graphene oxide (AGO) decorated chitosan (CS) namely AGO@CS composite beads was efficiently prepared for defluoridation studies.
34249341	11	0	theme	chemical	2006:2013	arg1	interaction					2015:2025	no chemical interaction	2003:2025	no chemical interaction between the GA	2003:2040	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	1	contain	possess	1736:1742	arg2	polymers					2046:2053	polymers	2046:2053	polymers	2046:2053	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	1	contain	possess	1736:1742	arg2	properties					1768:1777	superior wound dressing properties	1744:1777	superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA	1744:2040	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	1	contain	possess	1736:1742	arg1	films					1730:1734	all GA-loaded films	1716:1734	all GA-loaded films	1716:1734	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	2	2	theme	effective	328:336	arg1	dressing					359:366	an effective and affordable wound dressing	325:366	an effective and affordable wound dressing for chronic wounds	325:385	Hence, there is an imperative need to develop an effective and affordable wound dressing for chronic wounds.
34249341	9	3	theme	pre-formulation	1379:1393	arg1	studies					1395:1401	the pre-formulation studies	1375:1401	the pre-formulation studies	1375:1401	Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility.
34249341	12	4	theme	hydrocolloid	2097:2108	arg1	film					2110:2113	An SA-PC hydrocolloid film	2088:2113	An SA-PC hydrocolloid film incorporated with gallic acid as a potentially applicable wound dressing for low to medium suppurating chronic wounds	2088:2231	Conclusion: An SA-PC hydrocolloid film incorporated with gallic acid as a potentially applicable wound dressing for low to medium suppurating chronic wounds was successfully developed.
34249341	7	5	theme	film	1102:1105	arg1	formulation					1107:1117	the most satisfactory film formulation	1080:1117	the most satisfactory film formulation	1080:1117	The hydrocolloid films were developed using solvent-casting method and the most satisfactory film formulation was further incorporated with various GA concentrations (0.1%, 0.5% and 1%).
34249341	5	6	used	used	814:817	arg2	dressing					784:791	GA-loaded alginate-based hydrocolloid film dressing	741:791	GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment	741:870	Thus, this present study aimed to formulate and characterise GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment.
34249341	1	7	theme	economic	262:269	arg1	issues					271:276	serious global health care and economic issues	231:276	issues	271:276	Background: A dramatic growth in the prevalence of chronic wounds due to diabetes has represented serious global health care and economic issues.
34249341	4	8	theme	film	665:668	arg1	dressing					670:677	a stable and functional hydrocolloid film dressing	628:677	a stable and functional hydrocolloid film dressing	628:677	However, there is a scarcity of research that focuses on formulating GA into a stable and functional hydrocolloid film dressing.
34249341	3	9	theme	due	503:505	arg1	recovery					494:501	wound recovery	488:501	wound recovery due to their safety and comparatively low cost	488:548	Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost.
34249341	9	10	dep	along	1555:1559	arg1	with					1561:1564	with	1561:1564	with	1561:1564	Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility.
34249341	3	11	theme	low	541:543	arg1	cost					545:548	comparatively low cost	527:548	comparatively low cost	527:548	Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost.
34249341	1	12	theme	chronic	184:190	arg1	wounds					192:197	chronic wounds	184:197	chronic wounds	184:197	Background: A dramatic growth in the prevalence of chronic wounds due to diabetes has represented serious global health care and economic issues.
34249341	6	13	theme	sodium	947:952	arg1	SA					964:965	SA	964:965	SA	964:965	Methods: The hydrocolloid composite films were pre-formulated by blending sodium alginate (SA) with different combinations of polymers.
34249341	6	13	theme	sodium	947:952	arg1	alginate					954:961	sodium alginate	947:961	sodium alginate (SA)	947:966	Methods: The hydrocolloid composite films were pre-formulated by blending sodium alginate (SA) with different combinations of polymers.
34249341	9	14	located	found	1463:1467	arg2	film					1454:1457	sodium alginate-pectin (SA-PC) based hydrocolloid film	1404:1457	sodium alginate-pectin (SA-PC) based hydrocolloid film	1404:1457	Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility.
34249341	9	14	located	found	1463:1467	arg2	satisfactory					1484:1495	satisfactory	1484:1495	satisfactory	1484:1495	Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility.
34249341	9	14	located	found	1463:1467	arg1	studies					1395:1401	the pre-formulation studies	1375:1401	the pre-formulation studies	1375:1401	Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility.
34249341	4	15	theme	research	583:590	arg1	scarcity					571:578	a scarcity	569:578	a scarcity of research that focuses on formulating GA into a stable and functional hydrocolloid film dressing	569:677	However, there is a scarcity of research that focuses on formulating GA into a stable and functional hydrocolloid film dressing.
34249341	11	16	theme	GA-loaded	1720:1728	arg1	films					1730:1734	all GA-loaded films	1716:1734	all GA-loaded films	1716:1734	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	7	17	theme	solvent-casting	1053:1067	arg1	method					1069:1074	solvent-casting method	1053:1074	solvent-casting method	1053:1074	The hydrocolloid films were developed using solvent-casting method and the most satisfactory film formulation was further incorporated with various GA concentrations (0.1%, 0.5% and 1%).
34249341	11	18	theme	g/m	1936:1938	arg1	2/day					1940:1944	1112 g/m 2/day	1931:1944	1112 g/m 2/day	1931:1944	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	9	19	theme	based	1435:1439	arg1	satisfactory					1484:1495	satisfactory	1484:1495	satisfactory	1484:1495	Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility.
34249341	9	19	theme	based	1435:1439	arg1	film					1454:1457	sodium alginate-pectin (SA-PC) based hydrocolloid film	1404:1457	sodium alginate-pectin (SA-PC) based hydrocolloid film	1404:1457	Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility.
34249341	11	20	theme	moderate	1811:1818	arg1	viscosity					1820:1828	moderate viscosity	1811:1828	moderate viscosity (1600 mPa-s-3198 mPa-s)	1811:1852	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	20	theme	moderate	1811:1818	arg1	mPa-s-3198					1836:1845	1600 mPa-s-3198 mPa-s	1831:1851	1600 mPa-s-3198 mPa-s	1831:1851	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	21	theme	rate	1891:1894	arg1	polymers					2046:2053	polymers	2046:2053	polymers	2046:2053	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	21	theme	rate	1891:1894	arg1	properties					1768:1777	superior wound dressing properties	1744:1777	superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA	1744:2040	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	22	theme	expansion	1984:1992	arg1	rate					1994:1997	slower moisture absorption and film expansion rate	1948:1997	rate	1994:1997	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	8	23	theme	physicochemical	1252:1266	arg1	properties					1268:1277	their physicochemical properties	1246:1277	their physicochemical properties	1246:1277	The drug-loaded films were then characterised for their physicochemical properties to assess their potential use as drug delivery systems for chronic wound treatment.
34249341	11	24	theme	wound	1753:1757	arg1	properties					1768:1777	superior wound dressing properties	1744:1777	superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA	1744:2040	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	25	theme	vapor	1872:1876	arg1	rate					1891:1894	optimal moisture vapor transmission rate	1855:1894	optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day)	1855:1945	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	6	26	theme	composite	899:907	arg1	films					909:913	The hydrocolloid composite films	882:913	The hydrocolloid composite films	882:913	Methods: The hydrocolloid composite films were pre-formulated by blending sodium alginate (SA) with different combinations of polymers.
34249341	12	27	theme	chronic	2218:2224	arg1	wounds					2226:2231	low to medium suppurating chronic wounds	2192:2231	low to medium suppurating chronic wounds	2192:2231	Conclusion: An SA-PC hydrocolloid film incorporated with gallic acid as a potentially applicable wound dressing for low to medium suppurating chronic wounds was successfully developed.
34249341	4	28	theme	stable	630:635	arg1	dressing					670:677	a stable and functional hydrocolloid film dressing	628:677	a stable and functional hydrocolloid film dressing	628:677	However, there is a scarcity of research that focuses on formulating GA into a stable and functional hydrocolloid film dressing.
34249341	11	29	theme	1195	1897:1900	arg1	2/day					1906:1910	1195 g/m 2/day	1897:1910	1195 g/m 2/day	1897:1910	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	5	30	theme	wound	856:860	arg1	treatment					862:870	chronic wound treatment	848:870	chronic wound treatment	848:870	Thus, this present study aimed to formulate and characterise GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment.
34249341	6	31	theme	different	973:981	arg1	combinations					983:994	different combinations	973:994	different combinations of polymers	973:1006	Methods: The hydrocolloid composite films were pre-formulated by blending sodium alginate (SA) with different combinations of polymers.
34249341	4	32	theme	functional	641:650	arg1	dressing					670:677	a stable and functional hydrocolloid film dressing	628:677	a stable and functional hydrocolloid film dressing	628:677	However, there is a scarcity of research that focuses on formulating GA into a stable and functional hydrocolloid film dressing.
34249341	0	33	theme	gallic	84:89	arg1	acid					91:94	gallic acid	84:94	gallic acid for potential chronic wound healing	84:130	Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing.
34249341	1	34	from	growth	156:161	arg1	prevalence					170:179	the prevalence	166:179	the prevalence of chronic wounds due to diabetes	166:213	Background: A dramatic growth in the prevalence of chronic wounds due to diabetes has represented serious global health care and economic issues.
34249341	12	35	theme	low	2192:2194	arg1	wounds					2226:2231	low to medium suppurating chronic wounds	2192:2231	low to medium suppurating chronic wounds	2192:2231	Conclusion: An SA-PC hydrocolloid film incorporated with gallic acid as a potentially applicable wound dressing for low to medium suppurating chronic wounds was successfully developed.
34249341	8	36	theme	drug	1312:1315	arg1	systems					1326:1332	drug delivery systems	1312:1332	drug delivery systems for chronic wound treatment	1312:1360	The drug-loaded films were then characterised for their physicochemical properties to assess their potential use as drug delivery systems for chronic wound treatment.
34249341	8	36	theme	drug	1312:1315	arg1	use					1305:1307	their potential use	1289:1307	their potential use	1289:1307	The drug-loaded films were then characterised for their physicochemical properties to assess their potential use as drug delivery systems for chronic wound treatment.
34249341	11	37	dep	pH	1789:1790	arg1	range					1792:1796	range (3.97-4.04)	1792:1808	range (3.97-4.04)	1792:1808	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	38	theme	optimal	1855:1861	arg1	rate					1891:1894	optimal moisture vapor transmission rate	1855:1894	optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day)	1855:1945	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	5	39	theme	present	691:697	arg1	study					699:703	this present study	686:703	this present study	686:703	Thus, this present study aimed to formulate and characterise GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment.
34249341	11	40	theme	FTIR	2061:2064	arg1	analysis					2066:2073	FTIR analysis	2061:2073	FTIR analysis	2061:2073	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	12	41	theme	applicable	2162:2171	arg1	dressing					2179:2186	a potentially applicable wound dressing	2148:2186	a potentially applicable wound dressing for low to medium suppurating chronic wounds	2148:2231	Conclusion: An SA-PC hydrocolloid film incorporated with gallic acid as a potentially applicable wound dressing for low to medium suppurating chronic wounds was successfully developed.
34249341	8	42	theme	chronic	1338:1344	arg1	treatment					1352:1360	chronic wound treatment	1338:1360	chronic wound treatment	1338:1360	The drug-loaded films were then characterised for their physicochemical properties to assess their potential use as drug delivery systems for chronic wound treatment.
34249341	11	43	theme	viscosity	1820:1828	arg1	polymers					2046:2053	polymers	2046:2053	polymers	2046:2053	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	43	theme	viscosity	1820:1828	arg1	properties					1768:1777	superior wound dressing properties	1744:1777	superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA	1744:2040	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	5	44	theme	film	779:782	arg1	dressing					784:791	GA-loaded alginate-based hydrocolloid film dressing	741:791	GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment	741:870	Thus, this present study aimed to formulate and characterise GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment.
34249341	3	45	theme	gallic	453:458	arg1	GA					466:467	GA	466:467	GA	466:467	Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost.
34249341	3	45	theme	gallic	453:458	arg1	acid					460:463	bioactive compound gallic acid	434:463	bioactive compound gallic acid (GA)	434:468	Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost.
34249341	11	46	theme	mPa-s	1847:1851	arg1	viscosity					1820:1828	moderate viscosity	1811:1828	moderate viscosity (1600 mPa-s-3198 mPa-s)	1811:1852	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	46	theme	mPa-s	1847:1851	arg1	mPa-s-3198					1836:1845	1600 mPa-s-3198 mPa-s	1831:1851	1600 mPa-s-3198 mPa-s	1831:1851	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	3	47	theme	bioactive	434:442	arg1	GA					466:467	GA	466:467	GA	466:467	Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost.
34249341	3	47	theme	bioactive	434:442	arg1	acid					460:463	bioactive compound gallic acid	434:463	bioactive compound gallic acid (GA)	434:468	Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost.
34249341	0	48	theme	alginate	36:43	arg1	dressing					63:70	alginate hydrocolloid film dressing	36:70	alginate hydrocolloid film dressing	36:70	Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing.
34249341	7	49	theme	various	1149:1155	arg1	concentrations					1160:1173	various GA concentrations	1149:1173	various GA concentrations (0.1%, 0.5% and 1%)	1149:1193	The hydrocolloid films were developed using solvent-casting method and the most satisfactory film formulation was further incorporated with various GA concentrations (0.1%, 0.5% and 1%).
34249341	5	50	theme	alginate-based	751:764	arg1	dressing					784:791	GA-loaded alginate-based hydrocolloid film dressing	741:791	GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment	741:870	Thus, this present study aimed to formulate and characterise GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment.
34249341	9	51	theme	film	1579:1582	arg1	flexibility					1584:1594	satisfactory film flexibility	1566:1594	surface along with satisfactory film flexibility	1547:1594	Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility.
34249341	11	52	theme	acidic	1782:1787	arg1	pH					1789:1790	acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA	1782:2040	pH	1789:1790	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	53	theme	1237g/m	1913:1919	arg1	2/day					1921:1925	1237g/m 2/day	1913:1925	1237g/m 2/day	1913:1925	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	10	54	from	loading	1635:1641	arg1	%					1657:1657	0.1%	1654:1657	0.1%	1654:1657	The SA-PC film was chosen for further loading with GA in 0.1%, 0.5% and 1%.
34249341	10	54	from	loading	1635:1641	arg1	%					1663:1663	0.5%	1660:1663	0.5%	1660:1663	The SA-PC film was chosen for further loading with GA in 0.1%, 0.5% and 1%.
34249341	10	54	from	loading	1635:1641	arg1	%					1670:1670	1%	1669:1670	1%	1669:1670	The SA-PC film was chosen for further loading with GA in 0.1%, 0.5% and 1%.
34249341	1	55	theme	dramatic	147:154	arg1	growth					156:161	A dramatic growth	145:161	A dramatic growth in the prevalence of chronic wounds due to diabetes	145:213	Background: A dramatic growth in the prevalence of chronic wounds due to diabetes has represented serious global health care and economic issues.
34249341	3	56	theme	compound	444:451	arg1	GA					466:467	GA	466:467	GA	466:467	Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost.
34249341	3	56	theme	compound	444:451	arg1	acid					460:463	bioactive compound gallic acid	434:463	bioactive compound gallic acid (GA)	434:468	Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost.
34249341	2	57	theme	wound	353:357	arg1	dressing					359:366	an effective and affordable wound dressing	325:366	an effective and affordable wound dressing for chronic wounds	325:385	Hence, there is an imperative need to develop an effective and affordable wound dressing for chronic wounds.
34249341	1	58	theme	serious	231:237	arg1	care					253:256	serious global health care and economic issues	231:276	care	253:256	Background: A dramatic growth in the prevalence of chronic wounds due to diabetes has represented serious global health care and economic issues.
34249341	5	59	theme	GA-loaded	741:749	arg1	dressing					784:791	GA-loaded alginate-based hydrocolloid film dressing	741:791	GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment	741:870	Thus, this present study aimed to formulate and characterise GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment.
34249341	6	60	theme	hydrocolloid	886:897	arg1	films					909:913	The hydrocolloid composite films	882:913	The hydrocolloid composite films	882:913	Methods: The hydrocolloid composite films were pre-formulated by blending sodium alginate (SA) with different combinations of polymers.
34249341	1	61	theme	health	246:251	arg1	care					253:256	serious global health care and economic issues	231:276	care	253:256	Background: A dramatic growth in the prevalence of chronic wounds due to diabetes has represented serious global health care and economic issues.
34249341	11	62	theme	interaction	2015:2025	arg1	polymers					2046:2053	polymers	2046:2053	polymers	2046:2053	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	62	theme	interaction	2015:2025	arg1	properties					1768:1777	superior wound dressing properties	1744:1777	superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA	1744:2040	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	7	63	theme	satisfactory	1089:1100	arg1	formulation					1107:1117	the most satisfactory film formulation	1080:1117	the most satisfactory film formulation	1080:1117	The hydrocolloid films were developed using solvent-casting method and the most satisfactory film formulation was further incorporated with various GA concentrations (0.1%, 0.5% and 1%).
34249341	10	64	with	loading	1635:1641	arg1	GA					1648:1649	GA	1648:1649	GA	1648:1649	The SA-PC film was chosen for further loading with GA in 0.1%, 0.5% and 1%.
34249341	3	65	theme	recovery	494:501	arg1	context					477:483	the context	473:483	the context of wound recovery due to their safety and comparatively low cost	473:548	Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost.
34249341	0	66	theme	film	58:61	arg1	dressing					63:70	alginate hydrocolloid film dressing	36:70	alginate hydrocolloid film dressing	36:70	Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing.
34249341	2	67	theme	imperative	298:307	arg1	need					309:312	an imperative need	295:312	an imperative need to develop an effective and affordable wound dressing for chronic wounds	295:385	Hence, there is an imperative need to develop an effective and affordable wound dressing for chronic wounds.
34249341	8	68	theme	drug-loaded	1200:1210	arg1	films					1212:1216	The drug-loaded films	1196:1216	The drug-loaded films	1196:1216	The drug-loaded films were then characterised for their physicochemical properties to assess their potential use as drug delivery systems for chronic wound treatment.
34249341	11	69	theme	superior	1744:1751	arg1	properties					1768:1777	superior wound dressing properties	1744:1777	superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA	1744:2040	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	1	70	theme	wounds	192:197	arg1	prevalence					170:179	the prevalence	166:179	the prevalence of chronic wounds due to diabetes	166:213	Background: A dramatic growth in the prevalence of chronic wounds due to diabetes has represented serious global health care and economic issues.
34249341	11	71	theme	absorption	1964:1973	arg1	polymers					2046:2053	polymers	2046:2053	polymers	2046:2053	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	71	theme	absorption	1964:1973	arg1	properties					1768:1777	superior wound dressing properties	1744:1777	superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA	1744:2040	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	10	72	theme	SA-PC	1601:1605	arg1	film					1607:1610	The SA-PC film	1597:1610	The SA-PC film	1597:1610	The SA-PC film was chosen for further loading with GA in 0.1%, 0.5% and 1%.
34249341	11	73	theme	transmission	1878:1889	arg1	rate					1891:1894	optimal moisture vapor transmission rate	1855:1894	optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day)	1855:1945	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	74	dep	rate	1891:1894	arg1	2/day					1921:1925	1237g/m 2/day	1913:1925	1237g/m 2/day	1913:1925	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	74	dep	rate	1891:1894	arg1	2/day					1940:1944	1112 g/m 2/day	1931:1944	1112 g/m 2/day	1931:1944	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	74	dep	rate	1891:1894	arg1	2/day					1906:1910	1195 g/m 2/day	1897:1910	1195 g/m 2/day	1897:1910	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	9	75	theme	hydrocolloid	1441:1452	arg1	satisfactory					1484:1495	satisfactory	1484:1495	satisfactory	1484:1495	Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility.
34249341	9	75	theme	hydrocolloid	1441:1452	arg1	film					1454:1457	sodium alginate-pectin (SA-PC) based hydrocolloid film	1404:1457	sodium alginate-pectin (SA-PC) based hydrocolloid film	1404:1457	Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility.
34249341	11	76	theme	slower	1948:1953	arg1	absorption					1964:1973	slower moisture absorption and film expansion rate	1948:1997	absorption	1964:1973	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	7	77	theme	hydrocolloid	1013:1024	arg1	films					1026:1030	The hydrocolloid films	1009:1030	The hydrocolloid films	1009:1030	The hydrocolloid films were developed using solvent-casting method and the most satisfactory film formulation was further incorporated with various GA concentrations (0.1%, 0.5% and 1%).
34249341	11	78	theme	moisture	1863:1870	arg1	rate					1891:1894	optimal moisture vapor transmission rate	1855:1894	optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day)	1855:1945	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	79	theme	moisture	1955:1962	arg1	absorption					1964:1973	slower moisture absorption and film expansion rate	1948:1997	absorption	1964:1973	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	4	80	theme	hydrocolloid	652:663	arg1	dressing					670:677	a stable and functional hydrocolloid film dressing	628:677	a stable and functional hydrocolloid film dressing	628:677	However, there is a scarcity of research that focuses on formulating GA into a stable and functional hydrocolloid film dressing.
34249341	11	81	theme	dressing	1759:1766	arg1	properties					1768:1777	superior wound dressing properties	1744:1777	superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA	1744:2040	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	82	theme	g/m	1902:1904	arg1	2/day					1906:1910	1195 g/m 2/day	1897:1910	1195 g/m 2/day	1897:1910	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	6	83	theme	polymers	999:1006	arg1	combinations					983:994	different combinations	973:994	different combinations of polymers	973:1006	Methods: The hydrocolloid composite films were pre-formulated by blending sodium alginate (SA) with different combinations of polymers.
34249341	11	84	theme	film	1979:1982	arg1	rate					1994:1997	slower moisture absorption and film expansion rate	1948:1997	rate	1994:1997	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	12	85	theme	gallic	2133:2138	arg1	acid					2140:2143	gallic acid	2133:2143	gallic acid	2133:2143	Conclusion: An SA-PC hydrocolloid film incorporated with gallic acid as a potentially applicable wound dressing for low to medium suppurating chronic wounds was successfully developed.
34249341	11	86	theme	characterisation	1677:1692	arg1	studies					1694:1700	The characterisation studies	1673:1700	The characterisation studies	1673:1700	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	5	87	theme	chronic	848:854	arg1	treatment					862:870	chronic wound treatment	848:870	chronic wound treatment	848:870	Thus, this present study aimed to formulate and characterise GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment.
34249341	9	88	from	smoothness	1533:1542	arg1	flexibility					1584:1594	satisfactory film flexibility	1566:1594	surface along with satisfactory film flexibility	1547:1594	Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility.
34249341	9	88	from	smoothness	1533:1542	arg1	surface					1547:1553	surface	1547:1553	surface along with satisfactory film flexibility	1547:1594	Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility.
34249341	7	89	dep	concentrations	1160:1173	arg1	%					1179:1179	0.1%	1176:1179	0.1%	1176:1179	The hydrocolloid films were developed using solvent-casting method and the most satisfactory film formulation was further incorporated with various GA concentrations (0.1%, 0.5% and 1%).
34249341	7	89	dep	concentrations	1160:1173	arg1	%					1185:1185	0.5%	1182:1185	0.5%	1182:1185	The hydrocolloid films were developed using solvent-casting method and the most satisfactory film formulation was further incorporated with various GA concentrations (0.1%, 0.5% and 1%).
34249341	7	89	dep	concentrations	1160:1173	arg1	%					1192:1192	1%	1191:1192	1%	1191:1192	The hydrocolloid films were developed using solvent-casting method and the most satisfactory film formulation was further incorporated with various GA concentrations (0.1%, 0.5% and 1%).
34249341	8	90	theme	potential	1295:1303	arg1	systems					1326:1332	drug delivery systems	1312:1332	drug delivery systems for chronic wound treatment	1312:1360	The drug-loaded films were then characterised for their physicochemical properties to assess their potential use as drug delivery systems for chronic wound treatment.
34249341	8	90	theme	potential	1295:1303	arg1	use					1305:1307	their potential use	1289:1307	their potential use	1289:1307	The drug-loaded films were then characterised for their physicochemical properties to assess their potential use as drug delivery systems for chronic wound treatment.
34249341	0	91	theme	potential	100:108	arg1	healing					124:130	potential chronic wound healing	100:130	potential chronic wound healing	100:130	Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing.
34249341	11	92	theme	pH	1789:1790	arg1	polymers					2046:2053	polymers	2046:2053	polymers	2046:2053	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	11	92	theme	pH	1789:1790	arg1	properties					1768:1777	superior wound dressing properties	1744:1777	superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA	1744:2040	The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m 2/day, 1237g/m 2/day and 1112 g/m 2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis.
34249341	0	93	theme	wound	118:122	arg1	healing					124:130	potential chronic wound healing	100:130	potential chronic wound healing	100:130	Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing.
34249341	12	94	theme	wound	2173:2177	arg1	dressing					2179:2186	a potentially applicable wound dressing	2148:2186	a potentially applicable wound dressing for low to medium suppurating chronic wounds	2148:2231	Conclusion: An SA-PC hydrocolloid film incorporated with gallic acid as a potentially applicable wound dressing for low to medium suppurating chronic wounds was successfully developed.
34249341	8	95	theme	delivery	1317:1324	arg1	systems					1326:1332	drug delivery systems	1312:1332	drug delivery systems for chronic wound treatment	1312:1360	The drug-loaded films were then characterised for their physicochemical properties to assess their potential use as drug delivery systems for chronic wound treatment.
34249341	8	95	theme	delivery	1317:1324	arg1	use					1305:1307	their potential use	1289:1307	their potential use	1289:1307	The drug-loaded films were then characterised for their physicochemical properties to assess their potential use as drug delivery systems for chronic wound treatment.
34249341	2	96	theme	chronic	372:378	arg1	wounds					380:385	chronic wounds	372:385	chronic wounds	372:385	Hence, there is an imperative need to develop an effective and affordable wound dressing for chronic wounds.
34249341	5	97	theme	hydrocolloid	766:777	arg1	dressing					784:791	GA-loaded alginate-based hydrocolloid film dressing	741:791	GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment	741:870	Thus, this present study aimed to formulate and characterise GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment.
34249341	12	98	theme	SA-PC	2091:2095	arg1	film					2110:2113	An SA-PC hydrocolloid film	2088:2113	An SA-PC hydrocolloid film incorporated with gallic acid as a potentially applicable wound dressing for low to medium suppurating chronic wounds	2088:2231	Conclusion: An SA-PC hydrocolloid film incorporated with gallic acid as a potentially applicable wound dressing for low to medium suppurating chronic wounds was successfully developed.
34249341	7	99	theme	GA	1157:1158	arg1	concentrations					1160:1173	various GA concentrations	1149:1173	various GA concentrations (0.1%, 0.5% and 1%)	1149:1193	The hydrocolloid films were developed using solvent-casting method and the most satisfactory film formulation was further incorporated with various GA concentrations (0.1%, 0.5% and 1%).
34249341	10	100	theme	further	1627:1633	arg1	loading					1635:1641	further loading	1627:1641	further loading with GA in 0.1%, 0.5% and 1%	1627:1670	The SA-PC film was chosen for further loading with GA in 0.1%, 0.5% and 1%.
34249341	8	101	theme	wound	1346:1350	arg1	treatment					1352:1360	chronic wound treatment	1338:1360	chronic wound treatment	1338:1360	The drug-loaded films were then characterised for their physicochemical properties to assess their potential use as drug delivery systems for chronic wound treatment.
34249341	3	102	theme	acid	460:463	arg1	potential					421:429	the potential	417:429	the potential of bioactive compound gallic acid (GA)	417:468	Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost.
34249341	0	103	theme	hydrocolloid	45:56	arg1	dressing					63:70	alginate hydrocolloid film dressing	36:70	alginate hydrocolloid film dressing	36:70	Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing.
34249341	0	104	theme	chronic	110:116	arg1	healing					124:130	potential chronic wound healing	100:130	potential chronic wound healing	100:130	Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing.
34249341	0	105	theme	dressing	63:70	arg1	characterisation					16:31	characterisation	16:31	characterisation	16:31	Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing.
34249341	0	105	theme	dressing	63:70	arg1	Formulation					0:10	Formulation	0:10	Formulation	0:10	Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing.
34249341	12	106	dep	low	2192:2194	arg1	suppurating					2206:2216	suppurating	2206:2216	suppurating	2206:2216	Conclusion: An SA-PC hydrocolloid film incorporated with gallic acid as a potentially applicable wound dressing for low to medium suppurating chronic wounds was successfully developed.
34249341	12	106	dep	low	2192:2194	arg1	to					2196:2197	to	2196:2197	to	2196:2197	Conclusion: An SA-PC hydrocolloid film incorporated with gallic acid as a potentially applicable wound dressing for low to medium suppurating chronic wounds was successfully developed.
34249341	9	107	theme	satisfactory	1566:1577	arg1	flexibility					1584:1594	satisfactory film flexibility	1566:1594	surface along with satisfactory film flexibility	1547:1594	Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility.
34249341	3	108	theme	Recent	388:393	arg1	research					395:402	Recent research	388:402	Recent research	388:402	Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost.
34249341	3	109	theme	wound	488:492	arg1	recovery					494:501	wound recovery	488:501	wound recovery due to their safety and comparatively low cost	488:548	Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost.
34249341	2	110	theme	affordable	342:351	arg1	dressing					359:366	an effective and affordable wound dressing	325:366	an effective and affordable wound dressing for chronic wounds	325:385	Hence, there is an imperative need to develop an effective and affordable wound dressing for chronic wounds.
34249341	1	111	theme	global	239:244	arg1	care					253:256	serious global health care and economic issues	231:276	care	253:256	Background: A dramatic growth in the prevalence of chronic wounds due to diabetes has represented serious global health care and economic issues.
34651635	7	0	theme	fatty	1135:1139	arg1	acids					1141:1145	short-chain fatty acids	1123:1145	short-chain fatty acids (SCFAs) of the ileum and colon	1123:1176	DF consumption increased the concentrations of short-chain fatty acids (SCFAs) of the ileum and colon compared to the CON diet.
34651635	7	0	theme	fatty	1135:1139	arg1	SCFAs					1148:1152	SCFAs	1148:1152	SCFAs	1148:1152	DF consumption increased the concentrations of short-chain fatty acids (SCFAs) of the ileum and colon compared to the CON diet.
34651635	4	1	theme	ZO-1	764:767	arg1	expression					750:759	the expression	746:759	the expression of ZO-1, Occludin and MUC2	746:786	We found that INU but not MCC enhanced the colonic barrier function by promoting the expression of ZO-1, Occludin and MUC2 and reducing the colonic crypt depth.
34651635	7	2	theme	acids	1141:1145	arg1	concentrations					1105:1118	the concentrations	1101:1118	the concentrations of short-chain fatty acids (SCFAs) of the ileum and colon	1101:1176	DF consumption increased the concentrations of short-chain fatty acids (SCFAs) of the ileum and colon compared to the CON diet.
34651635	6	3	contain	contain	960:966	arg2	sialomucins					982:992	sialomucins	982:992	sialomucins	982:992	Goblet cells in the ileum were found to contain predominantly sialomucins while colonic goblet cells were dominated by sulfomucins with sialomucins absent.
34651635	6	3	contain	contain	960:966	arg1	cells					927:931	Goblet cells	920:931	Goblet cells in the ileum	920:944	Goblet cells in the ileum were found to contain predominantly sialomucins while colonic goblet cells were dominated by sulfomucins with sialomucins absent.
34651635	8	4	theme	gene	1238:1241	arg1	sequencing					1243:1252	16S rRNA gene sequencing	1229:1252	16S rRNA gene sequencing analysis	1229:1261	Moreover, the results of 16S rRNA gene sequencing analysis revealed that DFs significantly altered the composition of ileal and colonic mucosal microbiota.
34651635	10	5	theme	barrier	1735:1741	arg1	function					1743:1750	the barrier function	1731:1750	the barrier function	1731:1750	Collectively, these findings suggest that the intestinal mucosal microbiota and SCFAs induced by INU play a crucial role in modulating the chemotypes of mucin and the barrier function.
34651635	0	6	theme	barrier	93:99	arg1	function					101:108	mucosal barrier function	85:108	mucosal barrier function	85:108	Gut microbiota mediates the effects of inulin on enhancing sulfomucin production and mucosal barrier function in a pig model.
34651635	9	7	theme	mucosal	1529:1535	arg1	function-gene					1545:1557	the mucosal barrier function-gene	1525:1557	the mucosal barrier function-gene in pigs	1525:1565	Network analysis indicated that INU-induced changes in bacterial genera and SCFAs, such as Akkermansia and butyrate, were significantly related with sulfomucins and the mucosal barrier function-gene in pigs.
34651635	4	8	theme	Occludin	770:777	arg1	expression					750:759	the expression	746:759	the expression of ZO-1, Occludin and MUC2	746:786	We found that INU but not MCC enhanced the colonic barrier function by promoting the expression of ZO-1, Occludin and MUC2 and reducing the colonic crypt depth.
34651635	8	9	theme	16S	1229:1231	arg1	sequencing					1243:1252	16S rRNA gene sequencing	1229:1252	16S rRNA gene sequencing analysis	1229:1261	Moreover, the results of 16S rRNA gene sequencing analysis revealed that DFs significantly altered the composition of ileal and colonic mucosal microbiota.
34651635	7	10	dep	ileum	1162:1166	arg1	the					1158:1160	the	1158:1160	the	1158:1160	DF consumption increased the concentrations of short-chain fatty acids (SCFAs) of the ileum and colon compared to the CON diet.
34651635	10	11	theme	intestinal	1614:1623	arg1	microbiota					1633:1642	the intestinal mucosal microbiota	1610:1642	the intestinal mucosal microbiota	1610:1642	Collectively, these findings suggest that the intestinal mucosal microbiota and SCFAs induced by INU play a crucial role in modulating the chemotypes of mucin and the barrier function.
34651635	0	12	theme	mucosal	85:91	arg1	function					101:108	mucosal barrier function	85:108	mucosal barrier function	85:108	Gut microbiota mediates the effects of inulin on enhancing sulfomucin production and mucosal barrier function in a pig model.
34651635	9	13	theme	bacterial	1415:1423	arg1	genera					1425:1430	bacterial genera	1415:1430	bacterial genera	1415:1430	Network analysis indicated that INU-induced changes in bacterial genera and SCFAs, such as Akkermansia and butyrate, were significantly related with sulfomucins and the mucosal barrier function-gene in pigs.
34651635	1	14	theme	microbial	256:264	arg1	composition					276:286	the microbial community composition	252:286	the microbial community composition	252:286	Dietary fibers (DFs) have many beneficial effects on intestinal health by ameliorating intestinal inflammation and modulating the microbial community composition, thereby affecting the barrier function.
34651635	10	15	theme	mucosal	1625:1631	arg1	microbiota					1633:1642	the intestinal mucosal microbiota	1610:1642	the intestinal mucosal microbiota	1610:1642	Collectively, these findings suggest that the intestinal mucosal microbiota and SCFAs induced by INU play a crucial role in modulating the chemotypes of mucin and the barrier function.
34651635	3	16	dep	Pigs	475:478	arg1	six					481:483	six	481:483	six	481:483	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	9	17	from	function-gene	1545:1557	arg1	pigs					1562:1565	pigs	1562:1565	pigs	1562:1565	Network analysis indicated that INU-induced changes in bacterial genera and SCFAs, such as Akkermansia and butyrate, were significantly related with sulfomucins and the mucosal barrier function-gene in pigs.
34651635	2	18	theme	intestinal	431:440	arg1	microbiota					442:451	the intestinal microbiota and mucin chemotypes	427:472	microbiota	442:451	This study aims to characterize the gut microbiota of pigs fed with DFs, revealing a link between the intestinal microbiota and mucin chemotypes.
34651635	8	19	theme	rRNA	1233:1236	arg1	sequencing					1243:1252	16S rRNA gene sequencing	1229:1252	16S rRNA gene sequencing analysis	1229:1261	Moreover, the results of 16S rRNA gene sequencing analysis revealed that DFs significantly altered the composition of ileal and colonic mucosal microbiota.
34651635	2	20	theme	pigs	383:386	arg1	microbiota					369:378	the gut microbiota	361:378	the gut microbiota of pigs fed with DFs	361:399	This study aims to characterize the gut microbiota of pigs fed with DFs, revealing a link between the intestinal microbiota and mucin chemotypes.
34651635	6	21	theme	absent	1068:1073	arg1	sialomucins					1056:1066	sialomucins	1056:1066	sialomucins absent	1056:1073	Goblet cells in the ileum were found to contain predominantly sialomucins while colonic goblet cells were dominated by sulfomucins with sialomucins absent.
34651635	1	22	theme	many	152:155	arg1	effects					168:174	many beneficial effects	152:174	many beneficial effects on intestinal health	152:195	Dietary fibers (DFs) have many beneficial effects on intestinal health by ameliorating intestinal inflammation and modulating the microbial community composition, thereby affecting the barrier function.
34651635	0	23	theme	Gut	0:2	arg1	microbiota					4:13	Gut microbiota	0:13	Gut microbiota	0:13	Gut microbiota mediates the effects of inulin on enhancing sulfomucin production and mucosal barrier function in a pig model.
34651635	1	24	theme	community	266:274	arg1	composition					276:286	the microbial community composition	252:286	the microbial community composition	252:286	Dietary fibers (DFs) have many beneficial effects on intestinal health by ameliorating intestinal inflammation and modulating the microbial community composition, thereby affecting the barrier function.
34651635	8	25	theme	sequencing	1243:1252	arg1	analysis					1254:1261	16S rRNA gene sequencing analysis	1229:1261	16S rRNA gene sequencing analysis	1229:1261	Moreover, the results of 16S rRNA gene sequencing analysis revealed that DFs significantly altered the composition of ileal and colonic mucosal microbiota.
34651635	9	26	from	sulfomucins	1509:1519	arg1	pigs					1562:1565	pigs	1562:1565	pigs	1562:1565	Network analysis indicated that INU-induced changes in bacterial genera and SCFAs, such as Akkermansia and butyrate, were significantly related with sulfomucins and the mucosal barrier function-gene in pigs.
34651635	1	27	theme	beneficial	157:166	arg1	effects					168:174	many beneficial effects	152:174	many beneficial effects on intestinal health	152:195	Dietary fibers (DFs) have many beneficial effects on intestinal health by ameliorating intestinal inflammation and modulating the microbial community composition, thereby affecting the barrier function.
34651635	0	28	theme	pig	115:117	arg1	model					119:123	a pig model	113:123	a pig model	113:123	Gut microbiota mediates the effects of inulin on enhancing sulfomucin production and mucosal barrier function in a pig model.
34651635	4	29	theme	barrier	716:722	arg1	function					724:731	the colonic barrier function	704:731	the colonic barrier function	704:731	We found that INU but not MCC enhanced the colonic barrier function by promoting the expression of ZO-1, Occludin and MUC2 and reducing the colonic crypt depth.
34651635	10	30	theme	mucin	1721:1725	arg1	chemotypes					1707:1716	the chemotypes	1703:1716	the chemotypes of mucin	1703:1725	Collectively, these findings suggest that the intestinal mucosal microbiota and SCFAs induced by INU play a crucial role in modulating the chemotypes of mucin and the barrier function.
34651635	10	30	theme	mucin	1721:1725	arg1	function					1743:1750	the barrier function	1731:1750	the barrier function	1731:1750	Collectively, these findings suggest that the intestinal mucosal microbiota and SCFAs induced by INU play a crucial role in modulating the chemotypes of mucin and the barrier function.
34651635	9	31	theme	Network	1360:1366	arg1	analysis					1368:1375	Network analysis	1360:1375	Network analysis	1360:1375	Network analysis indicated that INU-induced changes in bacterial genera and SCFAs, such as Akkermansia and butyrate, were significantly related with sulfomucins and the mucosal barrier function-gene in pigs.
34651635	7	32	theme	DF	1076:1077	arg1	consumption					1079:1089	DF consumption	1076:1089	DF consumption	1076:1089	DF consumption increased the concentrations of short-chain fatty acids (SCFAs) of the ileum and colon compared to the CON diet.
34651635	5	33	theme	mRNA	866:869	arg1	levels					871:876	mRNA levels	866:876	mRNA levels	866:876	INU increased sulfomucin production and mRNA levels of sulfotransferases Gal3ST1 and Gal3ST2.
34651635	8	34	theme	mucosal	1340:1346	arg1	microbiota					1348:1357	ileal and colonic mucosal microbiota	1322:1357	ileal and colonic mucosal microbiota	1322:1357	Moreover, the results of 16S rRNA gene sequencing analysis revealed that DFs significantly altered the composition of ileal and colonic mucosal microbiota.
34651635	5	35	theme	sulfomucin	840:849	arg1	production					851:860	sulfomucin production	840:860	sulfomucin production	840:860	INU increased sulfomucin production and mRNA levels of sulfotransferases Gal3ST1 and Gal3ST2.
34651635	8	36	theme	analysis	1254:1261	arg1	results					1218:1224	the results	1214:1224	the results of 16S rRNA gene sequencing analysis	1214:1261	Moreover, the results of 16S rRNA gene sequencing analysis revealed that DFs significantly altered the composition of ileal and colonic mucosal microbiota.
34651635	1	37	theme	Dietary	126:132	arg1	fibers					134:139	Dietary fibers	126:139	Dietary fibers (DFs)	126:145	Dietary fibers (DFs) have many beneficial effects on intestinal health by ameliorating intestinal inflammation and modulating the microbial community composition, thereby affecting the barrier function.
34651635	1	37	theme	Dietary	126:132	arg1	DFs					142:144	DFs	142:144	DFs	142:144	Dietary fibers (DFs) have many beneficial effects on intestinal health by ameliorating intestinal inflammation and modulating the microbial community composition, thereby affecting the barrier function.
34651635	2	38	theme	mucin	457:461	arg1	chemotypes					463:472	the intestinal microbiota and mucin chemotypes	427:472	chemotypes	463:472	This study aims to characterize the gut microbiota of pigs fed with DFs, revealing a link between the intestinal microbiota and mucin chemotypes.
34651635	7	39	theme	CON	1194:1196	arg1	diet					1198:1201	the CON diet	1190:1201	the CON diet	1190:1201	DF consumption increased the concentrations of short-chain fatty acids (SCFAs) of the ileum and colon compared to the CON diet.
34651635	8	40	theme	colonic	1332:1338	arg1	microbiota					1348:1357	ileal and colonic mucosal microbiota	1322:1357	ileal and colonic mucosal microbiota	1322:1357	Moreover, the results of 16S rRNA gene sequencing analysis revealed that DFs significantly altered the composition of ileal and colonic mucosal microbiota.
34651635	4	41	theme	colonic	708:714	arg1	function					724:731	the colonic barrier function	704:731	the colonic barrier function	704:731	We found that INU but not MCC enhanced the colonic barrier function by promoting the expression of ZO-1, Occludin and MUC2 and reducing the colonic crypt depth.
34651635	1	42	theme	intestinal	179:188	arg1	health					190:195	intestinal health	179:195	intestinal health	179:195	Dietary fibers (DFs) have many beneficial effects on intestinal health by ameliorating intestinal inflammation and modulating the microbial community composition, thereby affecting the barrier function.
34651635	4	43	theme	crypt	813:817	arg1	depth					819:823	the colonic crypt depth	801:823	the colonic crypt depth	801:823	We found that INU but not MCC enhanced the colonic barrier function by promoting the expression of ZO-1, Occludin and MUC2 and reducing the colonic crypt depth.
34651635	1	44	contain	have	147:150	arg1	fibers					134:139	Dietary fibers	126:139	Dietary fibers (DFs)	126:145	Dietary fibers (DFs) have many beneficial effects on intestinal health by ameliorating intestinal inflammation and modulating the microbial community composition, thereby affecting the barrier function.
34651635	1	44	contain	have	147:150	arg2	effects					168:174	many beneficial effects	152:174	many beneficial effects on intestinal health	152:195	Dietary fibers (DFs) have many beneficial effects on intestinal health by ameliorating intestinal inflammation and modulating the microbial community composition, thereby affecting the barrier function.
34651635	1	44	contain	have	147:150	arg1	DFs					142:144	DFs	142:144	DFs	142:144	Dietary fibers (DFs) have many beneficial effects on intestinal health by ameliorating intestinal inflammation and modulating the microbial community composition, thereby affecting the barrier function.
34651635	9	45	from	changes	1404:1410	arg1	Akkermansia					1451:1461	Akkermansia	1451:1461	Akkermansia	1451:1461	Network analysis indicated that INU-induced changes in bacterial genera and SCFAs, such as Akkermansia and butyrate, were significantly related with sulfomucins and the mucosal barrier function-gene in pigs.
34651635	9	45	from	changes	1404:1410	arg1	SCFAs					1436:1440	SCFAs	1436:1440	SCFAs	1436:1440	Network analysis indicated that INU-induced changes in bacterial genera and SCFAs, such as Akkermansia and butyrate, were significantly related with sulfomucins and the mucosal barrier function-gene in pigs.
34651635	9	45	from	changes	1404:1410	arg1	butyrate					1467:1474	butyrate	1467:1474	butyrate	1467:1474	Network analysis indicated that INU-induced changes in bacterial genera and SCFAs, such as Akkermansia and butyrate, were significantly related with sulfomucins and the mucosal barrier function-gene in pigs.
34651635	9	45	from	changes	1404:1410	arg1	genera					1425:1430	bacterial genera	1415:1430	bacterial genera	1415:1430	Network analysis indicated that INU-induced changes in bacterial genera and SCFAs, such as Akkermansia and butyrate, were significantly related with sulfomucins and the mucosal barrier function-gene in pigs.
34651635	5	46	dep	sulfotransferases	881:897	arg1	Gal3ST1					899:905	Gal3ST1	899:905	Gal3ST1	899:905	INU increased sulfomucin production and mRNA levels of sulfotransferases Gal3ST1 and Gal3ST2.
34651635	5	46	dep	sulfotransferases	881:897	arg1	sulfotransferases					881:897	sulfotransferases Gal3ST1 and Gal3ST2	881:917	sulfotransferases Gal3ST1 and Gal3ST2	881:917	INU increased sulfomucin production and mRNA levels of sulfotransferases Gal3ST1 and Gal3ST2.
34651635	5	46	dep	sulfotransferases	881:897	arg1	Gal3ST2					911:917	Gal3ST2	911:917	Gal3ST2	911:917	INU increased sulfomucin production and mRNA levels of sulfotransferases Gal3ST1 and Gal3ST2.
34651635	6	47	with	sulfomucins	1039:1049	arg1	sialomucins					1056:1066	sialomucins	1056:1066	sialomucins absent	1056:1073	Goblet cells in the ileum were found to contain predominantly sialomucins while colonic goblet cells were dominated by sulfomucins with sialomucins absent.
34651635	4	48	theme	MUC2	783:786	arg1	expression					750:759	the expression	746:759	the expression of ZO-1, Occludin and MUC2	746:786	We found that INU but not MCC enhanced the colonic barrier function by promoting the expression of ZO-1, Occludin and MUC2 and reducing the colonic crypt depth.
34651635	8	49	theme	microbiota	1348:1357	arg1	composition					1307:1317	the composition	1303:1317	the composition of ileal and colonic mucosal microbiota	1303:1357	Moreover, the results of 16S rRNA gene sequencing analysis revealed that DFs significantly altered the composition of ileal and colonic mucosal microbiota.
34651635	3	50	theme	following	541:549	arg1	control					558:564	control	558:564	control (CON)	558:570	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	3	50	theme	following	541:549	arg1	diets					551:555	the following diets	537:555	the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days	537:662	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	3	50	theme	following	541:549	arg1	diet					577:580	a diet	575:580	a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days	575:662	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	6	51	theme	goblet	1008:1013	arg1	cells					1015:1019	colonic goblet cells	1000:1019	colonic goblet cells	1000:1019	Goblet cells in the ileum were found to contain predominantly sialomucins while colonic goblet cells were dominated by sulfomucins with sialomucins absent.
34651635	9	52	theme	INU-induced	1392:1402	arg1	changes					1404:1410	INU-induced changes	1392:1410	INU-induced changes in bacterial genera and SCFAs, such as Akkermansia and butyrate,	1392:1475	Network analysis indicated that INU-induced changes in bacterial genera and SCFAs, such as Akkermansia and butyrate, were significantly related with sulfomucins and the mucosal barrier function-gene in pigs.
34651635	0	53	theme	inulin	39:44	arg1	effects					28:34	the effects	24:34	the effects of inulin on enhancing sulfomucin production and mucosal barrier function in a pig model	24:123	Gut microbiota mediates the effects of inulin on enhancing sulfomucin production and mucosal barrier function in a pig model.
34651635	1	54	theme	barrier	311:317	arg1	function					319:326	the barrier function	307:326	the barrier function	307:326	Dietary fibers (DFs) have many beneficial effects on intestinal health by ameliorating intestinal inflammation and modulating the microbial community composition, thereby affecting the barrier function.
34651635	4	55	theme	colonic	805:811	arg1	depth					819:823	the colonic crypt depth	801:823	the colonic crypt depth	801:823	We found that INU but not MCC enhanced the colonic barrier function by promoting the expression of ZO-1, Occludin and MUC2 and reducing the colonic crypt depth.
34651635	3	56	theme	microcrystalline	603:618	arg1	MCC					631:633	MCC	631:633	MCC	631:633	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	3	56	theme	microcrystalline	603:618	arg1	cellulose					620:628	5% microcrystalline cellulose	600:628	5% microcrystalline cellulose (MCC)	600:634	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	3	57	theme	diets	551:555	arg1	one					530:532	one	530:532	one	530:532	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	3	57	theme	diets	551:555	arg1	control					558:564	control	558:564	control (CON)	558:570	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	3	57	theme	diets	551:555	arg1	diets					551:555	the following diets	537:555	the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days	537:662	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	3	57	theme	diets	551:555	arg1	diet					577:580	a diet	575:580	a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days	575:662	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	1	58	from	effects	168:174	arg1	health					190:195	intestinal health	179:195	intestinal health	179:195	Dietary fibers (DFs) have many beneficial effects on intestinal health by ameliorating intestinal inflammation and modulating the microbial community composition, thereby affecting the barrier function.
34651635	6	59	from	cells	927:931	arg1	ileum					940:944	the ileum	936:944	the ileum	936:944	Goblet cells in the ileum were found to contain predominantly sialomucins while colonic goblet cells were dominated by sulfomucins with sialomucins absent.
34651635	10	60	theme	crucial	1676:1682	arg1	role					1684:1687	a crucial role	1674:1687	a crucial role	1674:1687	Collectively, these findings suggest that the intestinal mucosal microbiota and SCFAs induced by INU play a crucial role in modulating the chemotypes of mucin and the barrier function.
34651635	7	61	theme	ileum	1162:1166	arg1	acids					1141:1145	short-chain fatty acids	1123:1145	short-chain fatty acids (SCFAs) of the ileum and colon	1123:1176	DF consumption increased the concentrations of short-chain fatty acids (SCFAs) of the ileum and colon compared to the CON diet.
34651635	7	61	theme	ileum	1162:1166	arg1	SCFAs					1148:1152	SCFAs	1148:1152	SCFAs	1148:1152	DF consumption increased the concentrations of short-chain fatty acids (SCFAs) of the ileum and colon compared to the CON diet.
34651635	3	62	theme	5	600:600	arg1	%					601:601	%	601:601	%	601:601	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	5	63	theme	sulfotransferases	881:897	arg1	production					851:860	sulfomucin production	840:860	sulfomucin production	840:860	INU increased sulfomucin production and mRNA levels of sulfotransferases Gal3ST1 and Gal3ST2.
34651635	5	63	theme	sulfotransferases	881:897	arg1	levels					871:876	mRNA levels	866:876	mRNA levels	866:876	INU increased sulfomucin production and mRNA levels of sulfotransferases Gal3ST1 and Gal3ST2.
34651635	7	64	theme	colon	1172:1176	arg1	acids					1141:1145	short-chain fatty acids	1123:1145	short-chain fatty acids (SCFAs) of the ileum and colon	1123:1176	DF consumption increased the concentrations of short-chain fatty acids (SCFAs) of the ileum and colon compared to the CON diet.
34651635	7	64	theme	colon	1172:1176	arg1	SCFAs					1148:1152	SCFAs	1148:1152	SCFAs	1148:1152	DF consumption increased the concentrations of short-chain fatty acids (SCFAs) of the ileum and colon compared to the CON diet.
34651635	6	65	theme	Goblet	920:925	arg1	cells					927:931	Goblet cells	920:931	Goblet cells in the ileum	920:944	Goblet cells in the ileum were found to contain predominantly sialomucins while colonic goblet cells were dominated by sulfomucins with sialomucins absent.
34651635	0	66	theme	sulfomucin	59:68	arg1	production					70:79	sulfomucin production	59:79	sulfomucin production	59:79	Gut microbiota mediates the effects of inulin on enhancing sulfomucin production and mucosal barrier function in a pig model.
34651635	3	67	theme	%	601:601	arg1	MCC					631:633	MCC	631:633	MCC	631:633	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	3	67	theme	%	601:601	arg1	cellulose					620:628	5% microcrystalline cellulose	600:628	5% microcrystalline cellulose (MCC)	600:634	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	9	68	theme	barrier	1537:1543	arg1	function-gene					1545:1557	the mucosal barrier function-gene	1525:1557	the mucosal barrier function-gene in pigs	1525:1565	Network analysis indicated that INU-induced changes in bacterial genera and SCFAs, such as Akkermansia and butyrate, were significantly related with sulfomucins and the mucosal barrier function-gene in pigs.
34651635	2	69	theme	gut	365:367	arg1	microbiota					369:378	the gut microbiota	361:378	the gut microbiota of pigs fed with DFs	361:399	This study aims to characterize the gut microbiota of pigs fed with DFs, revealing a link between the intestinal microbiota and mucin chemotypes.
34651635	3	70	dep	diets	551:555	arg1	CON					567:569	CON	567:569	CON	567:569	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	3	70	dep	diets	551:555	arg1	control					558:564	control	558:564	control (CON)	558:570	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	3	70	dep	diets	551:555	arg1	diet					577:580	a diet	575:580	a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days	575:662	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	3	70	dep	diets	551:555	arg1	diets					551:555	the following diets	537:555	the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days	537:662	Pigs (six per group) were randomly allotted to consume one of the following diets: control (CON) or a diet supplemented with 5% microcrystalline cellulose (MCC) or inulin (INU) for 72 days.
34651635	1	71	theme	intestinal	213:222	arg1	inflammation					224:235	intestinal inflammation	213:235	intestinal inflammation	213:235	Dietary fibers (DFs) have many beneficial effects on intestinal health by ameliorating intestinal inflammation and modulating the microbial community composition, thereby affecting the barrier function.
34651635	8	72	theme	ileal	1322:1326	arg1	microbiota					1348:1357	ileal and colonic mucosal microbiota	1322:1357	ileal and colonic mucosal microbiota	1322:1357	Moreover, the results of 16S rRNA gene sequencing analysis revealed that DFs significantly altered the composition of ileal and colonic mucosal microbiota.
34651635	6	73	theme	colonic	1000:1006	arg1	cells					1015:1019	colonic goblet cells	1000:1019	colonic goblet cells	1000:1019	Goblet cells in the ileum were found to contain predominantly sialomucins while colonic goblet cells were dominated by sulfomucins with sialomucins absent.
34651635	7	74	theme	short-chain	1123:1133	arg1	acids					1141:1145	short-chain fatty acids	1123:1145	short-chain fatty acids (SCFAs) of the ileum and colon	1123:1176	DF consumption increased the concentrations of short-chain fatty acids (SCFAs) of the ileum and colon compared to the CON diet.
34651635	7	74	theme	short-chain	1123:1133	arg1	SCFAs					1148:1152	SCFAs	1148:1152	SCFAs	1148:1152	DF consumption increased the concentrations of short-chain fatty acids (SCFAs) of the ileum and colon compared to the CON diet.
33641920	1	0	from	improvements	205:216	arg1	biomaterials					221:232	biomaterials	221:232	biomaterials	221:232	Shortages of organs and damaged tissues for transplantation have prompted improvements in biomaterials within the field of tissue engineering (TE).
33641920	9	1	theme	conductive	1175:1184	arg1	hydrogels					1186:1194	These conductive hydrogels	1169:1194	These conductive hydrogels	1169:1194	These conductive hydrogels have the potential to be used in a myriad of TE strategies, particularly for those focused on the incorporation of electroconductive components for applications such as cardiac or neuronal TE strategies.
33641920	5	2	theme	hybrid	721:726	arg1	hydrogels					738:746	These hybrid composite hydrogels	715:746	These hybrid composite hydrogels	715:746	These hybrid composite hydrogels were evaluated in terms of mechanical, chemical and cellular response.
33641920	9	3	theme	electroconductive	1311:1327	arg1	components					1329:1338	electroconductive components	1311:1338	electroconductive components for applications such as cardiac or neuronal TE strategies	1311:1397	These conductive hydrogels have the potential to be used in a myriad of TE strategies, particularly for those focused on the incorporation of electroconductive components for applications such as cardiac or neuronal TE strategies.
33641920	4	4	theme	preparation	628:638	arg1	method					640:645	the preparation method	624:645	the preparation method	624:645	Importantly, the preparation method allows the formation of hydrogels with homogenously dispersed CNFs.
33641920	5	5	theme	composite	728:736	arg1	hydrogels					738:746	These hybrid composite hydrogels	715:746	These hybrid composite hydrogels	715:746	These hybrid composite hydrogels were evaluated in terms of mechanical, chemical and cellular response.
33641920	7	6	theme	3-D	1075:1077	arg1	printing					1079:1086	3-D printing	1075:1086	3-D printing	1075:1086	CNF incorporation enhances shear-thinning behaviour, allowing ease of 3-D printing.
33641920	3	7	theme	3-D	596:598	arg1	scaffolds					600:608	electroconductive and printable 3-D scaffolds	564:608	electroconductive and printable 3-D scaffolds	564:608	In this work, hybrid printable biomaterials comprised of alginate and gelatin hydrogel systems filled with carbon nanofibers (CNFs) were developed to create electroconductive and printable 3-D scaffolds.
33641920	0	8	theme	tissue	111:116	arg1	engineering					118:128	tissue engineering	111:128	tissue engineering	111:128	Printable alginate/gelatin hydrogel reinforced with carbon nanofibers as electrically conductive scaffolds for tissue engineering.
33641920	9	9	theme	TE	1241:1242	arg1	strategies					1244:1253	TE strategies	1241:1253	TE strategies	1241:1253	These conductive hydrogels have the potential to be used in a myriad of TE strategies, particularly for those focused on the incorporation of electroconductive components for applications such as cardiac or neuronal TE strategies.
33641920	2	10	theme	hydrogels	298:306	arg1	rise					283:286	The rise	279:286	The rise of hybrid hydrogels as electro-conductive biomaterials	279:341	The rise of hybrid hydrogels as electro-conductive biomaterials offers promise in numerous challenging biomedical applications.
33641920	5	11	theme	response	809:816	arg1	terms					766:770	terms	766:770	terms of mechanical, chemical and cellular response	766:816	These hybrid composite hydrogels were evaluated in terms of mechanical, chemical and cellular response.
33641920	6	12	theme	4.1 × 10-4 ± 2 × 10-5	964:984	arg1	S/cm					986:989	4.1 × 10-4 ± 2 × 10-5 S/cm	964:989	4.1 × 10-4 ± 2 × 10-5 S/cm	964:989	They display excellent mechanical performance, which is augmented by the CNFs, with Young's moduli and conductivity reaching 534.7 ± 2.7 kPa and 4.1 × 10-4 ± 2 × 10-5 S/cm respectively.
33641920	8	13	theme	In-vitro	1089:1096	arg1	studies					1098:1104	In-vitro studies	1089:1104	In-vitro studies	1089:1104	In-vitro studies indicate improved cellular proliferation compared to controls.
33641920	2	14	theme	hybrid	291:296	arg1	hydrogels					298:306	hybrid hydrogels	291:306	hybrid hydrogels as electro-conductive biomaterials	291:341	The rise of hybrid hydrogels as electro-conductive biomaterials offers promise in numerous challenging biomedical applications.
33641920	3	15	theme	hydrogel	485:492	arg1	systems					494:500	gelatin hydrogel systems	477:500	gelatin hydrogel systems	477:500	In this work, hybrid printable biomaterials comprised of alginate and gelatin hydrogel systems filled with carbon nanofibers (CNFs) were developed to create electroconductive and printable 3-D scaffolds.
33641920	8	16	theme	improved	1115:1122	arg1	proliferation					1133:1145	improved cellular proliferation	1115:1145	improved cellular proliferation	1115:1145	In-vitro studies indicate improved cellular proliferation compared to controls.
33641920	0	17	theme	Printable	0:8	arg1	hydrogel					27:34	Printable alginate/gelatin hydrogel	0:34	Printable alginate/gelatin hydrogel	0:34	Printable alginate/gelatin hydrogel reinforced with carbon nanofibers as electrically conductive scaffolds for tissue engineering.
33641920	0	18	theme	alginate/gelatin	10:25	arg1	hydrogel					27:34	Printable alginate/gelatin hydrogel	0:34	Printable alginate/gelatin hydrogel	0:34	Printable alginate/gelatin hydrogel reinforced with carbon nanofibers as electrically conductive scaffolds for tissue engineering.
33641920	3	19	theme	electroconductive	564:580	arg1	scaffolds					600:608	electroconductive and printable 3-D scaffolds	564:608	electroconductive and printable 3-D scaffolds	564:608	In this work, hybrid printable biomaterials comprised of alginate and gelatin hydrogel systems filled with carbon nanofibers (CNFs) were developed to create electroconductive and printable 3-D scaffolds.
33641920	9	20	theme	components	1329:1338	arg1	incorporation					1294:1306	the incorporation	1290:1306	the incorporation of electroconductive components for applications such as cardiac or neuronal TE strategies	1290:1397	These conductive hydrogels have the potential to be used in a myriad of TE strategies, particularly for those focused on the incorporation of electroconductive components for applications such as cardiac or neuronal TE strategies.
33641920	3	21	theme	printable	428:436	arg1	biomaterials					438:449	hybrid printable biomaterials	421:449	hybrid printable biomaterials comprised of alginate and gelatin hydrogel systems filled with carbon nanofibers (CNFs)	421:537	In this work, hybrid printable biomaterials comprised of alginate and gelatin hydrogel systems filled with carbon nanofibers (CNFs) were developed to create electroconductive and printable 3-D scaffolds.
33641920	9	22	theme	neuronal	1376:1383	arg1	strategies					1388:1397	neuronal TE strategies	1376:1397	neuronal TE strategies	1376:1397	These conductive hydrogels have the potential to be used in a myriad of TE strategies, particularly for those focused on the incorporation of electroconductive components for applications such as cardiac or neuronal TE strategies.
33641920	3	23	theme	gelatin	477:483	arg1	systems					494:500	gelatin hydrogel systems	477:500	gelatin hydrogel systems	477:500	In this work, hybrid printable biomaterials comprised of alginate and gelatin hydrogel systems filled with carbon nanofibers (CNFs) were developed to create electroconductive and printable 3-D scaffolds.
33641920	7	24	theme	shear-thinning	1032:1045	arg1	behaviour					1047:1055	shear-thinning behaviour	1032:1055	shear-thinning behaviour	1032:1055	CNF incorporation enhances shear-thinning behaviour, allowing ease of 3-D printing.
33641920	3	25	theme	carbon	514:519	arg1	CNFs					533:536	CNFs	533:536	CNFs	533:536	In this work, hybrid printable biomaterials comprised of alginate and gelatin hydrogel systems filled with carbon nanofibers (CNFs) were developed to create electroconductive and printable 3-D scaffolds.
33641920	3	25	theme	carbon	514:519	arg1	nanofibers					521:530	carbon nanofibers	514:530	carbon nanofibers (CNFs)	514:537	In this work, hybrid printable biomaterials comprised of alginate and gelatin hydrogel systems filled with carbon nanofibers (CNFs) were developed to create electroconductive and printable 3-D scaffolds.
33641920	5	26	theme	mechanical	775:784	arg1	terms					766:770	terms	766:770	terms of mechanical, chemical and cellular response	766:816	These hybrid composite hydrogels were evaluated in terms of mechanical, chemical and cellular response.
33641920	2	27	theme	electro-conductive	311:328	arg1	biomaterials					330:341	electro-conductive biomaterials	311:341	electro-conductive biomaterials	311:341	The rise of hybrid hydrogels as electro-conductive biomaterials offers promise in numerous challenging biomedical applications.
33641920	0	28	theme	carbon	52:57	arg1	nanofibers					59:68	carbon nanofibers	52:68	carbon nanofibers	52:68	Printable alginate/gelatin hydrogel reinforced with carbon nanofibers as electrically conductive scaffolds for tissue engineering.
33641920	2	29	theme	challenging	370:380	arg1	applications					393:404	numerous challenging biomedical applications	361:404	numerous challenging biomedical applications	361:404	The rise of hybrid hydrogels as electro-conductive biomaterials offers promise in numerous challenging biomedical applications.
33641920	5	30	theme	chemical	787:794	arg1	terms					766:770	terms	766:770	terms of mechanical, chemical and cellular response	766:816	These hybrid composite hydrogels were evaluated in terms of mechanical, chemical and cellular response.
33641920	5	31	theme	cellular	800:807	arg1	response					809:816	cellular response	800:816	cellular response	800:816	These hybrid composite hydrogels were evaluated in terms of mechanical, chemical and cellular response.
33641920	6	32	theme	mechanical	842:851	arg1	performance					853:863	excellent mechanical performance	832:863	excellent mechanical performance	832:863	They display excellent mechanical performance, which is augmented by the CNFs, with Young's moduli and conductivity reaching 534.7 ± 2.7 kPa and 4.1 × 10-4 ± 2 × 10-5 S/cm respectively.
33641920	6	33	theme	excellent	832:840	arg1	performance					853:863	excellent mechanical performance	832:863	excellent mechanical performance	832:863	They display excellent mechanical performance, which is augmented by the CNFs, with Young's moduli and conductivity reaching 534.7 ± 2.7 kPa and 4.1 × 10-4 ± 2 × 10-5 S/cm respectively.
33641920	2	34	theme	biomedical	382:391	arg1	applications					393:404	numerous challenging biomedical applications	361:404	numerous challenging biomedical applications	361:404	The rise of hybrid hydrogels as electro-conductive biomaterials offers promise in numerous challenging biomedical applications.
33641920	9	35	contain	have	1196:1199	arg1	hydrogels					1186:1194	These conductive hydrogels	1169:1194	These conductive hydrogels	1169:1194	These conductive hydrogels have the potential to be used in a myriad of TE strategies, particularly for those focused on the incorporation of electroconductive components for applications such as cardiac or neuronal TE strategies.
33641920	9	35	contain	have	1196:1199	arg2	potential					1205:1213	the potential to be used in a myriad of TE strategies, particularly for those focused on the incorporation of electroconductive components for applications such as cardiac or neuronal TE strategies	1201:1397	the potential to be used in a myriad of TE strategies, particularly for those focused on the incorporation of electroconductive components for applications such as cardiac or neuronal TE strategies	1201:1397	These conductive hydrogels have the potential to be used in a myriad of TE strategies, particularly for those focused on the incorporation of electroconductive components for applications such as cardiac or neuronal TE strategies.
33641920	4	36	with	formation	658:666	arg1	CNFs					709:712	homogenously dispersed CNFs	686:712	homogenously dispersed CNFs	686:712	Importantly, the preparation method allows the formation of hydrogels with homogenously dispersed CNFs.
33641920	9	37	theme	strategies	1244:1253	arg1	myriad					1231:1236	a myriad	1229:1236	a myriad of TE strategies	1229:1253	These conductive hydrogels have the potential to be used in a myriad of TE strategies, particularly for those focused on the incorporation of electroconductive components for applications such as cardiac or neuronal TE strategies.
33641920	1	38	theme	organs	144:149	arg1	Shortages					131:139	Shortages	131:139	Shortages of organs and damaged tissues for transplantation	131:189	Shortages of organs and damaged tissues for transplantation have prompted improvements in biomaterials within the field of tissue engineering (TE).
33641920	7	39	theme	CNF	1005:1007	arg1	incorporation					1009:1021	CNF incorporation	1005:1021	CNF incorporation	1005:1021	CNF incorporation enhances shear-thinning behaviour, allowing ease of 3-D printing.
33641920	8	40	theme	cellular	1124:1131	arg1	proliferation					1133:1145	improved cellular proliferation	1115:1145	improved cellular proliferation	1115:1145	In-vitro studies indicate improved cellular proliferation compared to controls.
33641920	6	41	theme	Young	903:907	arg1	moduli					911:916	Young's moduli	903:916	Young's moduli	903:916	They display excellent mechanical performance, which is augmented by the CNFs, with Young's moduli and conductivity reaching 534.7 ± 2.7 kPa and 4.1 × 10-4 ± 2 × 10-5 S/cm respectively.
33641920	2	42	theme	numerous	361:368	arg1	applications					393:404	numerous challenging biomedical applications	361:404	numerous challenging biomedical applications	361:404	The rise of hybrid hydrogels as electro-conductive biomaterials offers promise in numerous challenging biomedical applications.
33641920	1	43	theme	tissue	254:259	arg1	TE					274:275	TE	274:275	TE	274:275	Shortages of organs and damaged tissues for transplantation have prompted improvements in biomaterials within the field of tissue engineering (TE).
33641920	1	43	theme	tissue	254:259	arg1	engineering					261:271	tissue engineering	254:271	tissue engineering (TE)	254:276	Shortages of organs and damaged tissues for transplantation have prompted improvements in biomaterials within the field of tissue engineering (TE).
33641920	3	44	theme	printable	586:594	arg1	scaffolds					600:608	electroconductive and printable 3-D scaffolds	564:608	electroconductive and printable 3-D scaffolds	564:608	In this work, hybrid printable biomaterials comprised of alginate and gelatin hydrogel systems filled with carbon nanofibers (CNFs) were developed to create electroconductive and printable 3-D scaffolds.
33641920	1	45	theme	damaged	155:161	arg1	tissues					163:169	damaged tissues	155:169	damaged tissues	155:169	Shortages of organs and damaged tissues for transplantation have prompted improvements in biomaterials within the field of tissue engineering (TE).
33641920	1	46	theme	engineering	261:271	arg1	field					245:249	the field	241:249	the field of tissue engineering (TE)	241:276	Shortages of organs and damaged tissues for transplantation have prompted improvements in biomaterials within the field of tissue engineering (TE).
33641920	0	47	theme	conductive	86:95	arg1	scaffolds					97:105	electrically conductive scaffolds	73:105	electrically conductive scaffolds for tissue engineering	73:128	Printable alginate/gelatin hydrogel reinforced with carbon nanofibers as electrically conductive scaffolds for tissue engineering.
33641920	4	48	theme	dispersed	699:707	arg1	CNFs					709:712	homogenously dispersed CNFs	686:712	homogenously dispersed CNFs	686:712	Importantly, the preparation method allows the formation of hydrogels with homogenously dispersed CNFs.
33641920	1	49	theme	tissues	163:169	arg1	Shortages					131:139	Shortages	131:139	Shortages of organs and damaged tissues for transplantation	131:189	Shortages of organs and damaged tissues for transplantation have prompted improvements in biomaterials within the field of tissue engineering (TE).
33641920	9	50	theme	TE	1385:1386	arg1	strategies					1388:1397	neuronal TE strategies	1376:1397	neuronal TE strategies	1376:1397	These conductive hydrogels have the potential to be used in a myriad of TE strategies, particularly for those focused on the incorporation of electroconductive components for applications such as cardiac or neuronal TE strategies.
33641920	7	51	theme	printing	1079:1086	arg1	ease					1067:1070	ease	1067:1070	ease of 3-D printing	1067:1086	CNF incorporation enhances shear-thinning behaviour, allowing ease of 3-D printing.
33641920	3	52	theme	hybrid	421:426	arg1	biomaterials					438:449	hybrid printable biomaterials	421:449	hybrid printable biomaterials comprised of alginate and gelatin hydrogel systems filled with carbon nanofibers (CNFs)	421:537	In this work, hybrid printable biomaterials comprised of alginate and gelatin hydrogel systems filled with carbon nanofibers (CNFs) were developed to create electroconductive and printable 3-D scaffolds.
33641920	4	53	theme	hydrogels	671:679	arg1	formation					658:666	the formation	654:666	the formation of hydrogels with homogenously dispersed CNFs	654:712	Importantly, the preparation method allows the formation of hydrogels with homogenously dispersed CNFs.
33125827	0	0	theme	lanthanide-doped	101:116	arg1	pigment					118:124	lanthanide-doped pigment	101:124	lanthanide-doped pigment	101:124	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.
33125827	5	1	theme	cellulose	858:866	arg1	film					868:871	The fabricated photoluminescence cellulose film	825:871	The fabricated photoluminescence cellulose film	825:871	The fabricated photoluminescence cellulose film exhibited an excitation peak at 436 nm and two fluorescence peaks at 494 and 524 nm.
33125827	6	2	theme	native	1173:1178	arg1	characteristics					1199:1213	its native physico-mechanical characteristics	1169:1213	its native physico-mechanical characteristics	1169:1213	The findings revealed that the originated nanocomposite films demonstrated improved superhydrophobic activity, high ultraviolet light protection and enhanced antibacterial activity without adversely influencing its native physico-mechanical characteristics.
33125827	2	3	theme	organic-inorganic	379:395	arg1	film					451:454	an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film	376:454	an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment	376:508	Here, we developed a simple formulation of an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment.
33125827	6	4	theme	enhanced	1107:1114	arg1	activity					1130:1137	enhanced antibacterial activity	1107:1137	enhanced antibacterial activity	1107:1137	The findings revealed that the originated nanocomposite films demonstrated improved superhydrophobic activity, high ultraviolet light protection and enhanced antibacterial activity without adversely influencing its native physico-mechanical characteristics.
33125827	6	5	theme	physico-mechanical	1180:1197	arg1	characteristics					1199:1213	its native physico-mechanical characteristics	1169:1213	its native physico-mechanical characteristics	1169:1213	The findings revealed that the originated nanocomposite films demonstrated improved superhydrophobic activity, high ultraviolet light protection and enhanced antibacterial activity without adversely influencing its native physico-mechanical characteristics.
33125827	1	6	theme	Smart	195:199	arg1	products					230:237	Smart photochromic and fluorescent products	195:237	Smart photochromic and fluorescent products	195:237	Smart photochromic and fluorescent products can respond to an external stimulus by changing their colour and emission spectra with light.
33125827	7	7	theme	photochromic	1259:1270	arg1	responsiveness					1272:1285	fast and reversible photochromic responsiveness	1239:1285	fast and reversible photochromic responsiveness	1239:1285	The films demonstrated fast and reversible photochromic responsiveness without fatigue during ultraviolet light irradiation.
33125827	5	8	theme	excitation	886:895	arg1	peak					897:900	an excitation peak	883:900	an excitation peak at 436 nm	883:910	The fabricated photoluminescence cellulose film exhibited an excitation peak at 436 nm and two fluorescence peaks at 494 and 524 nm.
33125827	5	9	from	nm	909:910	arg1	peaks					933:937	two fluorescence peaks	916:937	two fluorescence peaks at 494 and 524 nm	916:955	The fabricated photoluminescence cellulose film exhibited an excitation peak at 436 nm and two fluorescence peaks at 494 and 524 nm.
33125827	5	9	from	nm	909:910	arg1	peak					897:900	an excitation peak	883:900	an excitation peak at 436 nm	883:910	The fabricated photoluminescence cellulose film exhibited an excitation peak at 436 nm and two fluorescence peaks at 494 and 524 nm.
33125827	6	10	theme	light	1086:1090	arg1	protection					1092:1101	high ultraviolet light protection	1069:1101	high ultraviolet light protection	1069:1101	The findings revealed that the originated nanocomposite films demonstrated improved superhydrophobic activity, high ultraviolet light protection and enhanced antibacterial activity without adversely influencing its native physico-mechanical characteristics.
33125827	1	11	theme	emission	304:311	arg1	spectra					313:319	their colour and emission spectra	287:319	spectra	313:319	Smart photochromic and fluorescent products can respond to an external stimulus by changing their colour and emission spectra with light.
33125827	4	12	theme	lanthanide-doped	741:756	arg1	colourant					758:766	the lanthanide-doped colourant	737:766	the lanthanide-doped colourant	737:766	For better fabrication of the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED), the lanthanide-doped colourant must be well-dispersed physically without agglomeration.
33125827	5	13	theme	fluorescence	920:931	arg1	peaks					933:937	two fluorescence peaks	916:937	two fluorescence peaks at 494 and 524 nm	916:955	The fabricated photoluminescence cellulose film exhibited an excitation peak at 436 nm and two fluorescence peaks at 494 and 524 nm.
33125827	4	14	theme	multifunctional	661:675	arg1	composites					714:723	the multifunctional colourless pigment-cellulose acetate composites	657:723	the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED)	657:734	For better fabrication of the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED), the lanthanide-doped colourant must be well-dispersed physically without agglomeration.
33125827	2	15	theme	acetate	438:444	arg1	film					451:454	an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film	376:454	an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment	376:508	Here, we developed a simple formulation of an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment.
33125827	1	16	theme	photochromic	201:212	arg1	products					230:237	Smart photochromic and fluorescent products	195:237	Smart photochromic and fluorescent products	195:237	Smart photochromic and fluorescent products can respond to an external stimulus by changing their colour and emission spectra with light.
33125827	0	17	theme	ultraviolet	127:137	arg1	blocking					139:146	ultraviolet blocking	127:146	ultraviolet blocking	127:146	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.
33125827	7	18	theme	light	1322:1326	arg1	irradiation					1328:1338	ultraviolet light irradiation	1310:1338	ultraviolet light irradiation	1310:1338	The films demonstrated fast and reversible photochromic responsiveness without fatigue during ultraviolet light irradiation.
33125827	4	19	theme	better	635:640	arg1	fabrication					642:652	better fabrication	635:652	better fabrication of the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED)	635:734	For better fabrication of the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED), the lanthanide-doped colourant must be well-dispersed physically without agglomeration.
33125827	4	20	theme	composites	714:723	arg1	fabrication					642:652	better fabrication	635:652	better fabrication of the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED)	635:734	For better fabrication of the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED), the lanthanide-doped colourant must be well-dispersed physically without agglomeration.
33125827	2	21	theme	lanthanide-doped	485:500	arg1	pigment					502:508	a lanthanide-doped pigment	483:508	a lanthanide-doped pigment	483:508	Here, we developed a simple formulation of an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment.
33125827	1	22	theme	fluorescent	218:228	arg1	products					230:237	Smart photochromic and fluorescent products	195:237	Smart photochromic and fluorescent products	195:237	Smart photochromic and fluorescent products can respond to an external stimulus by changing their colour and emission spectra with light.
33125827	0	23	theme	Facile	0:5	arg1	development					7:17	Facile development	0:17	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.	0:193	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.
33125827	6	24	theme	ultraviolet	1074:1084	arg1	light					1086:1090	high ultraviolet light	1069:1090	high ultraviolet light protection	1069:1101	The findings revealed that the originated nanocomposite films demonstrated improved superhydrophobic activity, high ultraviolet light protection and enhanced antibacterial activity without adversely influencing its native physico-mechanical characteristics.
33125827	7	25	theme	fast	1239:1242	arg1	responsiveness					1272:1285	fast and reversible photochromic responsiveness	1239:1285	fast and reversible photochromic responsiveness	1239:1285	The films demonstrated fast and reversible photochromic responsiveness without fatigue during ultraviolet light irradiation.
33125827	2	26	theme	cellulose	428:436	arg1	CA					447:448	CA	447:448	CA	447:448	Here, we developed a simple formulation of an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment.
33125827	2	26	theme	cellulose	428:436	arg1	acetate					438:444	photoluminescent cellulose acetate	411:444	an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment	376:508	Here, we developed a simple formulation of an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment.
33125827	0	27	theme	photochromic	22:33	arg1	film					79:82	photochromic cellulose acetate transparent nanocomposite film	22:82	photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment	22:124	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.
33125827	6	28	theme	high	1069:1072	arg1	light					1086:1090	high ultraviolet light	1069:1090	high ultraviolet light protection	1069:1101	The findings revealed that the originated nanocomposite films demonstrated improved superhydrophobic activity, high ultraviolet light protection and enhanced antibacterial activity without adversely influencing its native physico-mechanical characteristics.
33125827	3	29	theme	optimal	590:596	arg1	wavelength					609:618	an optimal excitation wavelength	587:618	an optimal excitation wavelength	587:618	Strontium aluminium oxide pigment doped with Eu2+ and Dy3+ (SAOED) exhibits an optimal excitation wavelength at 365 nm.
33125827	3	30	theme	Strontium	511:519	arg1	pigment					537:543	Strontium aluminium oxide pigment	511:543	Strontium aluminium oxide pigment doped with Eu2+ and Dy3+ (SAOED)	511:576	Strontium aluminium oxide pigment doped with Eu2+ and Dy3+ (SAOED) exhibits an optimal excitation wavelength at 365 nm.
33125827	5	31	from	nm	954:955	arg1	peaks					933:937	two fluorescence peaks	916:937	two fluorescence peaks at 494 and 524 nm	916:955	The fabricated photoluminescence cellulose film exhibited an excitation peak at 436 nm and two fluorescence peaks at 494 and 524 nm.
33125827	5	31	from	nm	954:955	arg1	peak					897:900	an excitation peak	883:900	an excitation peak at 436 nm	883:910	The fabricated photoluminescence cellulose film exhibited an excitation peak at 436 nm and two fluorescence peaks at 494 and 524 nm.
33125827	3	32	theme	excitation	598:607	arg1	wavelength					609:618	an optimal excitation wavelength	587:618	an optimal excitation wavelength	587:618	Strontium aluminium oxide pigment doped with Eu2+ and Dy3+ (SAOED) exhibits an optimal excitation wavelength at 365 nm.
33125827	6	33	theme	originated	989:998	arg1	films					1014:1018	the originated nanocomposite films	985:1018	the originated nanocomposite films	985:1018	The findings revealed that the originated nanocomposite films demonstrated improved superhydrophobic activity, high ultraviolet light protection and enhanced antibacterial activity without adversely influencing its native physico-mechanical characteristics.
33125827	3	34	theme	aluminium	521:529	arg1	pigment					537:543	Strontium aluminium oxide pigment	511:543	Strontium aluminium oxide pigment doped with Eu2+ and Dy3+ (SAOED)	511:576	Strontium aluminium oxide pigment doped with Eu2+ and Dy3+ (SAOED) exhibits an optimal excitation wavelength at 365 nm.
33125827	0	35	theme	acetate	45:51	arg1	film					79:82	photochromic cellulose acetate transparent nanocomposite film	22:82	photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment	22:124	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.
33125827	4	36	theme	acetate	706:712	arg1	composites					714:723	the multifunctional colourless pigment-cellulose acetate composites	657:723	the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED)	657:734	For better fabrication of the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED), the lanthanide-doped colourant must be well-dispersed physically without agglomeration.
33125827	2	37	theme	film	451:454	arg1	formulation					361:371	a simple formulation	352:371	a simple formulation of an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment	352:508	Here, we developed a simple formulation of an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment.
33125827	0	38	theme	cellulose	35:43	arg1	film					79:82	photochromic cellulose acetate transparent nanocomposite film	22:82	photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment	22:124	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.
33125827	6	39	theme	superhydrophobic	1042:1057	arg1	activity					1059:1066	improved superhydrophobic activity	1033:1066	improved superhydrophobic activity	1033:1066	The findings revealed that the originated nanocomposite films demonstrated improved superhydrophobic activity, high ultraviolet light protection and enhanced antibacterial activity without adversely influencing its native physico-mechanical characteristics.
33125827	4	40	theme	pigment-cellulose	688:704	arg1	composites					714:723	the multifunctional colourless pigment-cellulose acetate composites	657:723	the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED)	657:734	For better fabrication of the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED), the lanthanide-doped colourant must be well-dispersed physically without agglomeration.
33125827	0	41	theme	nanocomposite	65:77	arg1	film					79:82	photochromic cellulose acetate transparent nanocomposite film	22:82	photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment	22:124	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.
33125827	6	42	theme	improved	1033:1040	arg1	activity					1059:1066	improved superhydrophobic activity	1033:1066	improved superhydrophobic activity	1033:1066	The findings revealed that the originated nanocomposite films demonstrated improved superhydrophobic activity, high ultraviolet light protection and enhanced antibacterial activity without adversely influencing its native physico-mechanical characteristics.
33125827	5	43	theme	photoluminescence	840:856	arg1	film					868:871	The fabricated photoluminescence cellulose film	825:871	The fabricated photoluminescence cellulose film	825:871	The fabricated photoluminescence cellulose film exhibited an excitation peak at 436 nm and two fluorescence peaks at 494 and 524 nm.
33125827	0	44	theme	transparent	53:63	arg1	film					79:82	photochromic cellulose acetate transparent nanocomposite film	22:82	photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment	22:124	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.
33125827	0	45	theme	antimicrobial	171:183	arg1	activity					185:192	antimicrobial activity	171:192	antimicrobial activity	171:192	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.
33125827	2	46	theme	pigment	502:508	arg1	immobilization					465:478	immobilization	465:478	immobilization of a lanthanide-doped pigment	465:508	Here, we developed a simple formulation of an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment.
33125827	7	47	theme	reversible	1248:1257	arg1	responsiveness					1272:1285	fast and reversible photochromic responsiveness	1239:1285	fast and reversible photochromic responsiveness	1239:1285	The films demonstrated fast and reversible photochromic responsiveness without fatigue during ultraviolet light irradiation.
33125827	7	48	theme	ultraviolet	1310:1320	arg1	irradiation					1328:1338	ultraviolet light irradiation	1310:1338	ultraviolet light irradiation	1310:1338	The films demonstrated fast and reversible photochromic responsiveness without fatigue during ultraviolet light irradiation.
33125827	2	49	theme	simple	354:359	arg1	formulation					361:371	a simple formulation	352:371	a simple formulation of an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment	352:508	Here, we developed a simple formulation of an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment.
33125827	1	50	theme	external	257:264	arg1	stimulus					266:273	an external stimulus	254:273	an external stimulus	254:273	Smart photochromic and fluorescent products can respond to an external stimulus by changing their colour and emission spectra with light.
33125827	3	51	theme	oxide	531:535	arg1	pigment					537:543	Strontium aluminium oxide pigment	511:543	Strontium aluminium oxide pigment doped with Eu2+ and Dy3+ (SAOED)	511:576	Strontium aluminium oxide pigment doped with Eu2+ and Dy3+ (SAOED) exhibits an optimal excitation wavelength at 365 nm.
33125827	5	52	theme	fabricated	829:838	arg1	film					868:871	The fabricated photoluminescence cellulose film	825:871	The fabricated photoluminescence cellulose film	825:871	The fabricated photoluminescence cellulose film exhibited an excitation peak at 436 nm and two fluorescence peaks at 494 and 524 nm.
33125827	0	53	dep	development	7:17	arg1	activity					185:192	antimicrobial activity	171:192	antimicrobial activity	171:192	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.
33125827	0	53	dep	development	7:17	arg1	superhydrophobic					149:164	superhydrophobic	149:164	superhydrophobic	149:164	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.
33125827	0	53	dep	development	7:17	arg1	blocking					139:146	ultraviolet blocking	127:146	ultraviolet blocking	127:146	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.
33125827	4	54	theme	colourless	677:686	arg1	composites					714:723	the multifunctional colourless pigment-cellulose acetate composites	657:723	the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED)	657:734	For better fabrication of the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED), the lanthanide-doped colourant must be well-dispersed physically without agglomeration.
33125827	2	55	theme	photoluminescent	411:426	arg1	CA					447:448	CA	447:448	CA	447:448	Here, we developed a simple formulation of an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment.
33125827	2	55	theme	photoluminescent	411:426	arg1	acetate					438:444	photoluminescent cellulose acetate	411:444	an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment	376:508	Here, we developed a simple formulation of an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment.
33125827	0	56	theme	film	79:82	arg1	development					7:17	Facile development	0:17	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.	0:193	Facile development of photochromic cellulose acetate transparent nanocomposite film immobilized with lanthanide-doped pigment: ultraviolet blocking, superhydrophobic, and antimicrobial activity.
33125827	6	57	theme	nanocomposite	1000:1012	arg1	films					1014:1018	the originated nanocomposite films	985:1018	the originated nanocomposite films	985:1018	The findings revealed that the originated nanocomposite films demonstrated improved superhydrophobic activity, high ultraviolet light protection and enhanced antibacterial activity without adversely influencing its native physico-mechanical characteristics.
33125827	4	58	dep	composites	714:723	arg1	CA-SAOED					726:733	CA-SAOED	726:733	CA-SAOED	726:733	For better fabrication of the multifunctional colourless pigment-cellulose acetate composites (CA-SAOED), the lanthanide-doped colourant must be well-dispersed physically without agglomeration.
33125827	2	59	theme	nanocomposite	397:409	arg1	film					451:454	an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film	376:454	an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment	376:508	Here, we developed a simple formulation of an organic-inorganic nanocomposite photoluminescent cellulose acetate (CA) film based on immobilization of a lanthanide-doped pigment.
33125827	6	60	theme	antibacterial	1116:1128	arg1	activity					1130:1137	enhanced antibacterial activity	1107:1137	enhanced antibacterial activity	1107:1137	The findings revealed that the originated nanocomposite films demonstrated improved superhydrophobic activity, high ultraviolet light protection and enhanced antibacterial activity without adversely influencing its native physico-mechanical characteristics.
34881496	6	0	from	understanding	1381:1393	arg1	growth					1445:1450	growth	1445:1450	growth	1445:1450	Our study had led to a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health.
34881496	6	0	from	understanding	1381:1393	arg1	health					1467:1472	intestinal health	1456:1472	intestinal health	1456:1472	Our study had led to a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health.
34881496	4	1	theme	immune	1042:1047	arg1	p > 0.05					1061:1068	p > 0.05	1061:1068	p > 0.05	1061:1068	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	4	1	theme	immune	1042:1047	arg1	parameters					1049:1058	the blood immune parameters	1032:1058	the blood immune parameters (p > 0.05)	1032:1069	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	6	2	from	health	1467:1472	arg1	understanding					1381:1393	a greater understanding	1371:1393	a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health	1371:1472	Our study had led to a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health.
34881496	1	3	theme	growth	229:234	arg1	performance					236:246	growth performance	229:246	growth performance	229:246	This study was conducted to examine the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	0	4	theme	growth	64:69	arg1	performance					71:81	growth performance	64:81	growth performance	64:81	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	3	5	dep	significantly	770:782	arg1	p < 0.05					785:792	p < 0.05	785:792	p < 0.05	785:792	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	4	6	theme	positive	963:970	arg1	p < 0.05					980:987	p < 0.05	980:987	p < 0.05	980:987	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	4	6	theme	positive	963:970	arg1	effect					972:977	a positive effect	961:977	a positive effect (p < 0.05)	961:988	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	0	7	theme	cecal	87:91	arg1	microbiota					93:102	cecal microbiota	87:102	cecal microbiota	87:102	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	0	8	from	Effects	0:6	arg1	performance					71:81	growth performance	64:81	growth performance	64:81	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	0	8	from	Effects	0:6	arg1	microbiota					93:102	cecal microbiota	87:102	cecal microbiota	87:102	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	2	9	theme	soybean	549:555	arg1	meals					557:561	soybean meals	549:561	soybean meals (positive control)	549:580	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	9	theme	soybean	549:555	arg1	control					573:579	positive control	564:579	positive control	564:579	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	6	10	from	effects	1408:1414	arg1	growth					1445:1450	growth	1445:1450	growth	1445:1450	Our study had led to a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health.
34881496	6	10	from	effects	1408:1414	arg1	health					1467:1472	intestinal health	1456:1472	intestinal health	1456:1472	Our study had led to a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health.
34881496	5	11	theme	family	1130:1135	arg1	level					1137:1141	the family level	1126:1141	the family level	1126:1141	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	3	12	theme	oligosaccharide	742:756	arg1	addition					722:729	addition	722:729	addition of soybean oligosaccharide to the diet	722:768	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	4	13	theme	blood	1036:1040	arg1	p > 0.05					1061:1068	p > 0.05	1061:1068	p > 0.05	1061:1068	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	4	13	theme	blood	1036:1040	arg1	parameters					1049:1058	the blood immune parameters	1032:1058	the blood immune parameters (p > 0.05)	1032:1069	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	3	14	theme	broiler	655:661	arg1	chickens					663:670	broiler chickens	655:670	broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG)	655:884	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	4	15	contain	had	957:959	arg1	Supplementation					887:901	Supplementation	887:901	Supplementation with soybean oligosaccharide, stachyose, or raffinose	887:955	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	4	15	contain	had	957:959	arg2	p < 0.05					980:987	p < 0.05	980:987	p < 0.05	980:987	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	4	15	contain	had	957:959	arg2	effect					972:977	a positive effect	961:977	a positive effect (p < 0.05)	961:988	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	5	16	theme	different	1322:1330	arg1	oligosaccharides					1332:1347	different oligosaccharides	1322:1347	different oligosaccharides	1322:1347	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	3	17	theme	daily	832:836	arg1	ADFI					851:854	ADFI	851:854	ADFI	851:854	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	3	17	theme	daily	832:836	arg1	intake					843:848	the average daily feed intake	820:848	the average daily feed intake (ADFI)	820:855	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	1	18	theme	cecal	252:256	arg1	microbiota					258:267	cecal microbiota	252:267	cecal microbiota	252:267	This study was conducted to examine the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	2	19	theme	total	514:518	arg1	content					526:532	0.6% total sugar content	509:532	0.6% total sugar content	509:532	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	5	20	theme	oligosaccharides	1332:1347	arg1	addition					1310:1317	dietary addition	1302:1317	dietary addition of different oligosaccharides	1302:1347	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	3	21	from	decreases	807:815	arg1	ADG					881:883	ADG	881:883	ADG	881:883	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	3	21	from	decreases	807:815	arg1	gain					875:878	average daily gain	861:878	average daily gain (ADG)	861:884	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	3	21	from	decreases	807:815	arg1	ADFI					851:854	ADFI	851:854	ADFI	851:854	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	3	21	from	decreases	807:815	arg1	intake					843:848	the average daily feed intake	820:848	the average daily feed intake (ADFI)	820:855	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	3	22	theme	feed	838:841	arg1	ADFI					851:854	ADFI	851:854	ADFI	851:854	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	3	22	theme	feed	838:841	arg1	intake					843:848	the average daily feed intake	820:848	the average daily feed intake (ADFI)	820:855	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	5	23	from	treatments	1237:1246	arg1	present					1218:1224	present	1218:1224	present	1218:1224	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	4	24	theme	soybean	908:914	arg1	oligosaccharide					916:930	soybean oligosaccharide	908:930	soybean oligosaccharide	908:930	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	5	25	located	present	1218:1224	arg1	treatments					1237:1246	all the treatments	1229:1246	all the treatments	1229:1246	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	5	25	located	present	1218:1224	arg2	Lachnospiraceae					1161:1175	Lachnospiraceae	1161:1175	Lachnospiraceae	1161:1175	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	5	25	located	present	1218:1224	arg2	Lactobacillaceae					1182:1197	Lactobacillaceae	1182:1197	Lactobacillaceae	1182:1197	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	5	25	located	present	1218:1224	arg1	level					1137:1141	the family level	1126:1141	the family level	1126:1141	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	5	26	theme	sequencing	1096:1105	arg1	results					1076:1082	The results	1072:1082	The results of the gene sequencing	1072:1105	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	6	27	theme	intestinal	1456:1465	arg1	health					1467:1472	intestinal health	1456:1472	intestinal health	1456:1472	Our study had led to a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health.
34881496	1	28	from	microbiota	258:267	arg1	chickens					280:287	broiler chickens	272:287	broiler chickens	272:287	This study was conducted to examine the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	6	29	from	growth	1445:1450	arg1	understanding					1381:1393	a greater understanding	1371:1393	a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health	1371:1472	Our study had led to a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health.
34881496	2	30	theme	Arbor	314:318	arg1	chickens					334:341	Three-hundred 1-day-old Arbor Acres broiler chickens	290:341	Three-hundred 1-day-old Arbor Acres broiler chickens	290:341	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	3	31	theme	average	824:830	arg1	ADFI					851:854	ADFI	851:854	ADFI	851:854	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	3	31	theme	average	824:830	arg1	intake					843:848	the average daily feed intake	820:848	the average daily feed intake (ADFI)	820:855	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	2	32	theme	positive	564:571	arg1	meals					557:561	soybean meals	549:561	soybean meals (positive control)	549:580	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	32	theme	positive	564:571	arg1	control					573:579	positive control	564:579	positive control	564:579	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	33	theme	1-day-old	304:312	arg1	chickens					334:341	Three-hundred 1-day-old Arbor Acres broiler chickens	290:341	Three-hundred 1-day-old Arbor Acres broiler chickens	290:341	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	6	34	theme	effects	1408:1414	arg1	understanding					1381:1393	a greater understanding	1371:1393	a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health	1371:1472	Our study had led to a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health.
34881496	2	35	theme	dietary	374:380	arg1	diet					402:405	a basal diet	394:405	a basal diet (control diet)	394:420	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	35	theme	dietary	374:380	arg1	treatments					382:391	five dietary treatments	369:391	five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control)	369:580	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	35	theme	dietary	374:380	arg1	diet					539:542	diet	539:542	diet	539:542	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	0	36	theme	oligosaccharide	19:33	arg1	Effects					0:6	Effects	0:6	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.	0:123	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	3	37	dep	improved	632:639	arg1	p < 0.05					642:649	p < 0.05	642:649	p < 0.05	642:649	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	2	38	theme	sugar	520:524	arg1	content					526:532	0.6% total sugar content	509:532	0.6% total sugar content	509:532	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	4	39	with	Supplementation	887:901	arg1	stachyose					933:941	stachyose	933:941	stachyose	933:941	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	4	39	with	Supplementation	887:901	arg1	raffinose					947:955	raffinose	947:955	raffinose	947:955	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	4	39	with	Supplementation	887:901	arg1	oligosaccharide					916:930	soybean oligosaccharide	908:930	soybean oligosaccharide	908:930	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	2	40	theme	Three-hundred	290:302	arg1	chickens					334:341	Three-hundred 1-day-old Arbor Acres broiler chickens	290:341	Three-hundred 1-day-old Arbor Acres broiler chickens	290:341	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	6	41	theme	prebiotic	1398:1406	arg1	effects					1408:1414	prebiotic effects	1398:1414	prebiotic effects of these oligosaccharides on growth and intestinal health	1398:1472	Our study had led to a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health.
34881496	1	42	theme	soybean	176:182	arg1	oligosaccharide					184:198	soybean oligosaccharide	176:198	soybean oligosaccharide	176:198	This study was conducted to examine the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	0	43	theme	soybean	11:17	arg1	oligosaccharide					19:33	soybean oligosaccharide	11:33	soybean oligosaccharide	11:33	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	1	44	theme	broiler	272:278	arg1	chickens					280:287	broiler chickens	272:287	broiler chickens	272:287	This study was conducted to examine the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	0	45	theme	broiler	107:113	arg1	chickens					115:122	broiler chickens	107:122	broiler chickens	107:122	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	0	46	from	performance	71:81	arg1	chickens					115:122	broiler chickens	107:122	broiler chickens	107:122	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	1	47	theme	oligosaccharide	184:198	arg1	effects					165:171	the effects	161:171	the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens	161:287	This study was conducted to examine the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	0	48	theme	stachyose	36:44	arg1	Effects					0:6	Effects	0:6	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.	0:123	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	6	49	theme	oligosaccharides	1425:1440	arg1	effects					1408:1414	prebiotic effects	1398:1414	prebiotic effects of these oligosaccharides on growth and intestinal health	1398:1472	Our study had led to a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health.
34881496	2	50	theme	%	512:512	arg1	content					526:532	0.6% total sugar content	509:532	0.6% total sugar content	509:532	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	3	51	theme	feed-to-gain	603:614	arg1	F/G					623:625	F/G	623:625	F/G	623:625	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	3	51	theme	feed-to-gain	603:614	arg1	ratio					616:620	feed-to-gain ratio	603:620	feed-to-gain ratio (F/G)	603:626	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	4	52	theme	nutrient	997:1004	arg1	digestibility					1006:1018	the nutrient digestibility	993:1018	the nutrient digestibility	993:1018	Supplementation with soybean oligosaccharide, stachyose, or raffinose had a positive effect (p < 0.05) on the nutrient digestibility, but not on the blood immune parameters (p > 0.05).
34881496	2	53	theme	soybean	447:453	arg1	oligosaccharide					455:469	soybean oligosaccharide	447:469	soybean oligosaccharide	447:469	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	1	54	from	performance	236:246	arg1	chickens					280:287	broiler chickens	272:287	broiler chickens	272:287	This study was conducted to examine the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	3	55	theme	daily	869:873	arg1	ADG					881:883	ADG	881:883	ADG	881:883	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	3	55	theme	daily	869:873	arg1	gain					875:878	average daily gain	861:878	average daily gain (ADG)	861:884	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	1	56	theme	stachyose	201:209	arg1	effects					165:171	the effects	161:171	the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens	161:287	This study was conducted to examine the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	5	57	theme	cecal	1256:1260	arg1	composition					1272:1282	the cecal microbial composition	1252:1282	the cecal microbial composition	1252:1282	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	2	58	theme	0.6	509:511	arg1	%					512:512	%	512:512	%	512:512	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	5	59	theme	microbial	1262:1270	arg1	composition					1272:1282	the cecal microbial composition	1252:1282	the cecal microbial composition	1252:1282	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	6	60	theme	greater	1373:1379	arg1	understanding					1381:1393	a greater understanding	1371:1393	a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health	1371:1472	Our study had led to a greater understanding of prebiotic effects of these oligosaccharides on growth and intestinal health.
34881496	5	61	theme	dietary	1302:1308	arg1	addition					1310:1317	dietary addition	1302:1317	dietary addition of different oligosaccharides	1302:1347	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	0	62	from	microbiota	93:102	arg1	chickens					115:122	broiler chickens	107:122	broiler chickens	107:122	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	2	63	dep	treatments	382:391	arg1	diet					402:405	a basal diet	394:405	a basal diet (control diet)	394:420	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	63	dep	treatments	382:391	arg1	diet					416:419	control diet	408:419	control diet	408:419	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	63	dep	treatments	382:391	arg1	diets					423:427	diets	423:427	diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content	423:532	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	63	dep	treatments	382:391	arg1	treatments					382:391	five dietary treatments	369:391	five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control)	369:580	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	63	dep	treatments	382:391	arg1	diet					539:542	diet	539:542	diet	539:542	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	3	64	theme	average	861:867	arg1	ADG					881:883	ADG	881:883	ADG	881:883	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	3	64	theme	average	861:867	arg1	gain					875:878	average daily gain	861:878	average daily gain (ADG)	861:884	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	2	65	theme	broiler	326:332	arg1	chickens					334:341	Three-hundred 1-day-old Arbor Acres broiler chickens	290:341	Three-hundred 1-day-old Arbor Acres broiler chickens	290:341	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	5	66	from	level	1137:1141	arg1	present					1218:1224	present	1218:1224	present	1218:1224	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	5	67	theme	gene	1091:1094	arg1	sequencing					1096:1105	the gene sequencing	1087:1105	the gene sequencing	1087:1105	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	2	68	theme	content	526:532	arg1	levels					499:504	levels	499:504	levels of 0.6% total sugar content	499:532	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	1	69	from	effects	165:171	arg1	performance					236:246	growth performance	229:246	growth performance	229:246	This study was conducted to examine the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	1	69	from	effects	165:171	arg1	microbiota					258:267	cecal microbiota	252:267	cecal microbiota	252:267	This study was conducted to examine the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	2	70	theme	Acres	320:324	arg1	chickens					334:341	Three-hundred 1-day-old Arbor Acres broiler chickens	290:341	Three-hundred 1-day-old Arbor Acres broiler chickens	290:341	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	3	71	theme	soybean	734:740	arg1	oligosaccharide					742:756	soybean oligosaccharide	734:756	soybean oligosaccharide	734:756	Results showed that feed-to-gain ratio (F/G) was improved (p < 0.05) in broiler chickens that received stachyose, but not raffinose, while addition of soybean oligosaccharide to the diet significantly (p < 0.05) resulted in decreases in the average daily feed intake (ADFI) and average daily gain (ADG).
34881496	2	72	theme	basal	396:400	arg1	diet					402:405	a basal diet	394:405	a basal diet (control diet)	394:420	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	72	theme	basal	396:400	arg1	diet					416:419	control diet	408:419	control diet	408:419	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	72	theme	basal	396:400	arg1	treatments					382:391	five dietary treatments	369:391	five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control)	369:580	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	73	theme	control	408:414	arg1	diet					402:405	a basal diet	394:405	a basal diet (control diet)	394:420	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	73	theme	control	408:414	arg1	diet					416:419	control diet	408:419	control diet	408:419	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	1	74	theme	raffinose	216:224	arg1	effects					165:171	the effects	161:171	the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens	161:287	This study was conducted to examine the effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	0	75	theme	raffinose	51:59	arg1	Effects					0:6	Effects	0:6	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.	0:123	Effects of soybean oligosaccharide, stachyose, and raffinose on growth performance and cecal microbiota in broiler chickens.
34881496	2	76	with	treatments	382:391	arg1	meals					557:561	soybean meals	549:561	soybean meals (positive control)	549:580	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	2	76	with	treatments	382:391	arg1	control					573:579	positive control	564:579	positive control	564:579	Three-hundred 1-day-old Arbor Acres broiler chickens were randomly assigned to five dietary treatments: a basal diet (control diet); diets supplemented with soybean oligosaccharide, stachyose, or raffinose at levels of 0.6% total sugar content; and diet with soybean meals (positive control).
34881496	5	77	attach	present	1218:1224	arg1	treatments					1237:1246	all the treatments	1229:1246	all the treatments	1229:1246	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	5	77	attach	present	1218:1224	arg2	Lachnospiraceae					1161:1175	Lachnospiraceae	1161:1175	Lachnospiraceae	1161:1175	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	5	77	attach	present	1218:1224	arg2	Lactobacillaceae					1182:1197	Lactobacillaceae	1182:1197	Lactobacillaceae	1182:1197	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	5	77	attach	present	1218:1224	arg1	level					1137:1141	the family level	1126:1141	the family level	1126:1141	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34881496	5	78	from	present	1218:1224	arg1	treatments					1237:1246	all the treatments	1229:1246	all the treatments	1229:1246	The results of the gene sequencing indicated that, at the family level, Ruminococcaceae, Lachnospiraceae, and Lactobacillaceae were comparatively present in all the treatments but the cecal microbial composition was changed after dietary addition of different oligosaccharides.
34906587	0	0	theme	washing	85:91	arg1	agent					93:97	a dual responsive nanoclay/sodium alginate surface washing agent	34:97	a dual responsive nanoclay/sodium alginate surface washing agent	34:97	Cleanup of oiled shorelines using a dual responsive nanoclay/sodium alginate surface washing agent.
34906587	6	1	theme	significant	943:953	arg1	effects					955:961	significant effects	943:961	significant effects on the oil removal efficiency of the NS washing fluid	943:1015	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	2	theme	factorial	749:757	arg1	design					759:764	the factorial design	745:764	the factorial design analysis	745:773	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	3	3	theme	nanoclay	499:506	arg1	spacing					488:494	the interlayer spacing	473:494	the interlayer spacing of nanoclay	473:506	The characterization results demonstrated that sodium alginate combined with nanoclay via hydrogen bonds, and was inserted into the interlayer spacing of nanoclay.
34906587	8	4	theme	Green	1143:1147	arg1	emulsion					1180:1187	Green materials-stabilized Pickering emulsion	1143:1187	Green materials-stabilized Pickering emulsion	1143:1187	Green materials-stabilized Pickering emulsion can potentially be used for oil/water separation.
34906587	0	5	theme	surface	77:83	arg1	agent					93:97	a dual responsive nanoclay/sodium alginate surface washing agent	34:97	a dual responsive nanoclay/sodium alginate surface washing agent	34:97	Cleanup of oiled shorelines using a dual responsive nanoclay/sodium alginate surface washing agent.
34906587	4	6	theme	sodium	516:521	arg1	alginate					523:530	sodium alginate	516:530	sodium alginate	516:530	Adding sodium alginate reduced surface and interfacial tensions, while increasing the viscoelasticity of the washing fluid.
34906587	10	7	theme	interesting	1406:1416	arg1	avenue					1418:1423	an interesting avenue	1403:1423	an interesting avenue for designing economical, high performance, and green washing agents	1403:1492	Our work opens an interesting avenue for designing economical, high performance, and green washing agents.
34906587	6	8	dep	factors	800:806	arg1	factors					800:806	three single factors	787:806	three single factors (temperature, oil concentration, and salinity)	787:853	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	8	dep	factors	800:806	arg1	temperature					809:819	temperature	809:819	temperature	809:819	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	8	dep	factors	800:806	arg1	concentration					826:838	oil concentration	822:838	oil concentration	822:838	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	8	dep	factors	800:806	arg1	salinity					845:852	salinity	845:852	salinity	845:852	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	5	9	theme	oil	681:683	arg1	performance					693:703	oil removal performance	681:703	oil removal performance	681:703	Batch experiments were conducted to investigate oil removal performance under various conditions.
34906587	6	10	theme	fluid	1011:1015	arg1	efficiency					982:991	the oil removal efficiency	966:991	the oil removal efficiency of the NS washing fluid	966:1015	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	3	11	theme	characterization	349:364	arg1	results					366:372	The characterization results	345:372	The characterization results	345:372	The characterization results demonstrated that sodium alginate combined with nanoclay via hydrogen bonds, and was inserted into the interlayer spacing of nanoclay.
34906587	5	12	theme	removal	685:691	arg1	performance					693:703	oil removal performance	681:703	oil removal performance	681:703	Batch experiments were conducted to investigate oil removal performance under various conditions.
34906587	9	13	theme	NS	1243:1244	arg1	agent					1254:1258	The NS washing agent	1239:1258	The NS washing agent	1239:1258	The NS washing agent displayed excellent pH- and Ca2+- responsiveness, generating transparent supernatants with low oil concentration and turbidity.
34906587	6	14	theme	washing	1003:1009	arg1	fluid					1011:1015	the NS washing fluid	996:1015	the NS washing fluid	996:1015	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	15	theme	oil	911:913	arg1	effects					876:882	two interactive effects	860:882	two interactive effects (temperature/salinity; and oil concentration/HA)	860:931	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	15	theme	oil	911:913	arg1	concentration/HA					915:930	oil concentration/HA	911:930	oil concentration/HA	911:930	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	5	16	theme	Batch	633:637	arg1	experiments					639:649	Batch experiments	633:649	Batch experiments	633:649	Batch experiments were conducted to investigate oil removal performance under various conditions.
34906587	9	17	theme	washing	1246:1252	arg1	agent					1254:1258	The NS washing agent	1239:1258	The NS washing agent	1239:1258	The NS washing agent displayed excellent pH- and Ca2+- responsiveness, generating transparent supernatants with low oil concentration and turbidity.
34906587	8	18	theme	oil/water	1217:1225	arg1	separation					1227:1236	oil/water separation	1217:1236	oil/water separation	1217:1236	Green materials-stabilized Pickering emulsion can potentially be used for oil/water separation.
34906587	6	19	theme	oil	822:824	arg1	concentration					826:838	oil concentration	822:838	oil concentration	822:838	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	19	theme	oil	822:824	arg1	factors					800:806	three single factors	787:806	three single factors (temperature, oil concentration, and salinity)	787:853	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	8	20	used	used	1208:1211	arg2	emulsion					1180:1187	Green materials-stabilized Pickering emulsion	1143:1187	Green materials-stabilized Pickering emulsion	1143:1187	Green materials-stabilized Pickering emulsion can potentially be used for oil/water separation.
34906587	2	21	theme	application	295:305	arg1	potential					307:315	its application potential	291:315	its application potential	291:315	In this study, we developed a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid, and systematically evaluated its application potential in oiled shoreline cleanup.
34906587	3	22	theme	sodium	392:397	arg1	alginate					399:406	that sodium alginate	387:406	that sodium alginate	387:406	The characterization results demonstrated that sodium alginate combined with nanoclay via hydrogen bonds, and was inserted into the interlayer spacing of nanoclay.
34906587	6	23	theme	NS	1000:1001	arg1	fluid					1011:1015	the NS washing fluid	996:1015	the NS washing fluid	996:1015	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	9	24	theme	excellent	1270:1278	arg1	responsiveness					1294:1307	excellent pH- and Ca2+- responsiveness	1270:1307	excellent pH- and Ca2+- responsiveness	1270:1307	The NS washing agent displayed excellent pH- and Ca2+- responsiveness, generating transparent supernatants with low oil concentration and turbidity.
34906587	7	25	theme	oily	1132:1135	arg1	sand					1137:1140	oily sand	1132:1140	oily sand	1132:1140	Compared to the commercial surfactants, the NS composite exhibited satisfactory removal efficiencies for treating oily sand.
34906587	3	26	theme	hydrogen	435:442	arg1	bonds					444:448	hydrogen bonds	435:448	hydrogen bonds	435:448	The characterization results demonstrated that sodium alginate combined with nanoclay via hydrogen bonds, and was inserted into the interlayer spacing of nanoclay.
34906587	0	27	theme	shorelines	17:26	arg1	Cleanup					0:6	Cleanup	0:6	Cleanup of oiled shorelines	0:26	Cleanup of oiled shorelines using a dual responsive nanoclay/sodium alginate surface washing agent.
34906587	4	28	theme	interfacial	552:562	arg1	tensions					564:571	interfacial tensions	552:571	interfacial tensions	552:571	Adding sodium alginate reduced surface and interfacial tensions, while increasing the viscoelasticity of the washing fluid.
34906587	7	29	theme	removal	1098:1104	arg1	efficiencies					1106:1117	satisfactory removal efficiencies	1085:1117	satisfactory removal efficiencies for treating oily sand	1085:1140	Compared to the commercial surfactants, the NS composite exhibited satisfactory removal efficiencies for treating oily sand.
34906587	9	30	theme	pH-	1280:1282	arg1	responsiveness					1294:1307	excellent pH- and Ca2+- responsiveness	1270:1307	excellent pH- and Ca2+- responsiveness	1270:1307	The NS washing agent displayed excellent pH- and Ca2+- responsiveness, generating transparent supernatants with low oil concentration and turbidity.
34906587	1	31	theme	Oil	100:102	arg1	spills					104:109	Oil spills	100:109	Oil spills	100:109	Oil spills may affect ecosystems and endanger public health.
34906587	0	32	theme	oiled	11:15	arg1	shorelines					17:26	oiled shorelines	11:26	oiled shorelines	11:26	Cleanup of oiled shorelines using a dual responsive nanoclay/sodium alginate surface washing agent.
34906587	6	33	dep	effects	876:882	arg1	effects					876:882	two interactive effects	860:882	two interactive effects (temperature/salinity; and oil concentration/HA)	860:931	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	33	dep	effects	876:882	arg1	concentration/HA					915:930	oil concentration/HA	911:930	oil concentration/HA	911:930	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	33	dep	effects	876:882	arg1	temperature/salinity					885:904	temperature/salinity	885:904	temperature/salinity	885:904	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	9	34	theme	Ca2+-	1288:1292	arg1	responsiveness					1294:1307	excellent pH- and Ca2+- responsiveness	1270:1307	excellent pH- and Ca2+- responsiveness	1270:1307	The NS washing agent displayed excellent pH- and Ca2+- responsiveness, generating transparent supernatants with low oil concentration and turbidity.
34906587	2	35	theme	nanoclay/sodium	217:231	arg1	NS					243:244	NS	243:244	NS	243:244	In this study, we developed a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid, and systematically evaluated its application potential in oiled shoreline cleanup.
34906587	2	35	theme	nanoclay/sodium	217:231	arg1	alginate					233:240	a novel and dual responsive nanoclay/sodium alginate	189:240	a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid	189:259	In this study, we developed a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid, and systematically evaluated its application potential in oiled shoreline cleanup.
34906587	8	36	theme	Pickering	1170:1178	arg1	emulsion					1180:1187	Green materials-stabilized Pickering emulsion	1143:1187	Green materials-stabilized Pickering emulsion	1143:1187	Green materials-stabilized Pickering emulsion can potentially be used for oil/water separation.
34906587	6	37	theme	removal	974:980	arg1	efficiency					982:991	the oil removal efficiency	966:991	the oil removal efficiency of the NS washing fluid	966:1015	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	7	38	theme	satisfactory	1085:1096	arg1	efficiencies					1106:1117	satisfactory removal efficiencies	1085:1117	satisfactory removal efficiencies for treating oily sand	1085:1140	Compared to the commercial surfactants, the NS composite exhibited satisfactory removal efficiencies for treating oily sand.
34906587	2	39	theme	responsive	206:215	arg1	NS					243:244	NS	243:244	NS	243:244	In this study, we developed a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid, and systematically evaluated its application potential in oiled shoreline cleanup.
34906587	2	39	theme	responsive	206:215	arg1	alginate					233:240	a novel and dual responsive nanoclay/sodium alginate	189:240	a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid	189:259	In this study, we developed a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid, and systematically evaluated its application potential in oiled shoreline cleanup.
34906587	7	40	theme	commercial	1034:1043	arg1	surfactants					1045:1055	the commercial surfactants	1030:1055	the commercial surfactants	1030:1055	Compared to the commercial surfactants, the NS composite exhibited satisfactory removal efficiencies for treating oily sand.
34906587	0	41	theme	responsive	41:50	arg1	agent					93:97	a dual responsive nanoclay/sodium alginate surface washing agent	34:97	a dual responsive nanoclay/sodium alginate surface washing agent	34:97	Cleanup of oiled shorelines using a dual responsive nanoclay/sodium alginate surface washing agent.
34906587	6	42	theme	oil	970:972	arg1	efficiency					982:991	the oil removal efficiency	966:991	the oil removal efficiency of the NS washing fluid	966:1015	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	7	43	theme	NS	1062:1063	arg1	composite					1065:1073	the NS composite	1058:1073	the NS composite	1058:1073	Compared to the commercial surfactants, the NS composite exhibited satisfactory removal efficiencies for treating oily sand.
34906587	6	44	theme	interactive	864:874	arg1	effects					876:882	two interactive effects	860:882	two interactive effects (temperature/salinity; and oil concentration/HA)	860:931	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	44	theme	interactive	864:874	arg1	concentration/HA					915:930	oil concentration/HA	911:930	oil concentration/HA	911:930	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	44	theme	interactive	864:874	arg1	temperature/salinity					885:904	temperature/salinity	885:904	temperature/salinity	885:904	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	2	45	theme	dual	201:204	arg1	NS					243:244	NS	243:244	NS	243:244	In this study, we developed a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid, and systematically evaluated its application potential in oiled shoreline cleanup.
34906587	2	45	theme	dual	201:204	arg1	alginate					233:240	a novel and dual responsive nanoclay/sodium alginate	189:240	a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid	189:259	In this study, we developed a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid, and systematically evaluated its application potential in oiled shoreline cleanup.
34906587	6	46	theme	single	793:798	arg1	salinity					845:852	salinity	845:852	salinity	845:852	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	46	theme	single	793:798	arg1	temperature					809:819	temperature	809:819	temperature	809:819	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	46	theme	single	793:798	arg1	concentration					826:838	oil concentration	822:838	oil concentration	822:838	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	6	46	theme	single	793:798	arg1	factors					800:806	three single factors	787:806	three single factors (temperature, oil concentration, and salinity)	787:853	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	2	47	theme	shoreline	326:334	arg1	cleanup					336:342	oiled shoreline cleanup	320:342	oiled shoreline cleanup	320:342	In this study, we developed a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid, and systematically evaluated its application potential in oiled shoreline cleanup.
34906587	0	48	theme	dual	36:39	arg1	agent					93:97	a dual responsive nanoclay/sodium alginate surface washing agent	34:97	a dual responsive nanoclay/sodium alginate surface washing agent	34:97	Cleanup of oiled shorelines using a dual responsive nanoclay/sodium alginate surface washing agent.
34906587	2	49	theme	novel	191:195	arg1	NS					243:244	NS	243:244	NS	243:244	In this study, we developed a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid, and systematically evaluated its application potential in oiled shoreline cleanup.
34906587	2	49	theme	novel	191:195	arg1	alginate					233:240	a novel and dual responsive nanoclay/sodium alginate	189:240	a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid	189:259	In this study, we developed a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid, and systematically evaluated its application potential in oiled shoreline cleanup.
34906587	10	50	theme	washing	1479:1485	arg1	agents					1487:1492	green washing agents	1473:1492	green washing agents	1473:1492	Our work opens an interesting avenue for designing economical, high performance, and green washing agents.
34906587	9	51	theme	oil	1355:1357	arg1	concentration					1359:1371	low oil concentration	1351:1371	low oil concentration	1351:1371	The NS washing agent displayed excellent pH- and Ca2+- responsiveness, generating transparent supernatants with low oil concentration and turbidity.
34906587	2	52	theme	oiled	320:324	arg1	cleanup					336:342	oiled shoreline cleanup	320:342	oiled shoreline cleanup	320:342	In this study, we developed a novel and dual responsive nanoclay/sodium alginate (NS) washing fluid, and systematically evaluated its application potential in oiled shoreline cleanup.
34906587	10	53	theme	green	1473:1477	arg1	agents					1487:1492	green washing agents	1473:1492	green washing agents	1473:1492	Our work opens an interesting avenue for designing economical, high performance, and green washing agents.
34906587	5	54	theme	various	711:717	arg1	conditions					719:728	various conditions	711:728	various conditions	711:728	Batch experiments were conducted to investigate oil removal performance under various conditions.
34906587	9	55	theme	transparent	1321:1331	arg1	supernatants					1333:1344	transparent supernatants	1321:1344	transparent supernatants	1321:1344	The NS washing agent displayed excellent pH- and Ca2+- responsiveness, generating transparent supernatants with low oil concentration and turbidity.
34906587	4	56	theme	washing	618:624	arg1	fluid					626:630	the washing fluid	614:630	the washing fluid	614:630	Adding sodium alginate reduced surface and interfacial tensions, while increasing the viscoelasticity of the washing fluid.
34906587	8	57	theme	materials-stabilized	1149:1168	arg1	emulsion					1180:1187	Green materials-stabilized Pickering emulsion	1143:1187	Green materials-stabilized Pickering emulsion	1143:1187	Green materials-stabilized Pickering emulsion can potentially be used for oil/water separation.
34906587	3	58	theme	interlayer	477:486	arg1	spacing					488:494	the interlayer spacing	473:494	the interlayer spacing of nanoclay	473:506	The characterization results demonstrated that sodium alginate combined with nanoclay via hydrogen bonds, and was inserted into the interlayer spacing of nanoclay.
34906587	0	59	theme	alginate	68:75	arg1	agent					93:97	a dual responsive nanoclay/sodium alginate surface washing agent	34:97	a dual responsive nanoclay/sodium alginate surface washing agent	34:97	Cleanup of oiled shorelines using a dual responsive nanoclay/sodium alginate surface washing agent.
34906587	10	60	theme	high	1451:1454	arg1	performance					1456:1466	high performance	1451:1466	high performance	1451:1466	Our work opens an interesting avenue for designing economical, high performance, and green washing agents.
34906587	0	61	theme	nanoclay/sodium	52:66	arg1	agent					93:97	a dual responsive nanoclay/sodium alginate surface washing agent	34:97	a dual responsive nanoclay/sodium alginate surface washing agent	34:97	Cleanup of oiled shorelines using a dual responsive nanoclay/sodium alginate surface washing agent.
34906587	9	62	theme	low	1351:1353	arg1	concentration					1359:1371	low oil concentration	1351:1371	low oil concentration	1351:1371	The NS washing agent displayed excellent pH- and Ca2+- responsiveness, generating transparent supernatants with low oil concentration and turbidity.
34906587	6	63	theme	design	759:764	arg1	analysis					766:773	the factorial design analysis	745:773	the factorial design analysis	745:773	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	1	64	theme	public	146:151	arg1	health					153:158	public health	146:158	public health	146:158	Oil spills may affect ecosystems and endanger public health.
34906587	6	65	from	effects	955:961	arg1	efficiency					982:991	the oil removal efficiency	966:991	the oil removal efficiency of the NS washing fluid	966:1015	Additionally, the factorial design analysis showed that three single factors (temperature, oil concentration, and salinity), and two interactive effects (temperature/salinity; and oil concentration/HA) displayed significant effects on the oil removal efficiency of the NS washing fluid.
34906587	4	66	theme	fluid	626:630	arg1	viscoelasticity					595:609	the viscoelasticity	591:609	the viscoelasticity of the washing fluid	591:630	Adding sodium alginate reduced surface and interfacial tensions, while increasing the viscoelasticity of the washing fluid.
33793546	4	0	theme	antibody	559:566	arg1	signatures					576:585	generic antibody binding signatures	551:585	generic antibody binding signatures	551:585	By mapping steric accessibility, structural rigidity, sequence conservation, and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for structure-based vaccine design.
33793546	3	1	theme	multi-microsecond	283:299	arg1	simulations					320:330	multi-microsecond molecular dynamics simulations	283:330	multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins	283:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	4	2	theme	vaccine	679:685	arg1	design					687:692	structure-based vaccine design	663:692	structure-based vaccine design	663:692	By mapping steric accessibility, structural rigidity, sequence conservation, and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for structure-based vaccine design.
33793546	4	3	theme	generic	551:557	arg1	signatures					576:585	generic antibody binding signatures	551:585	generic antibody binding signatures	551:585	By mapping steric accessibility, structural rigidity, sequence conservation, and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for structure-based vaccine design.
33793546	4	4	theme	steric	481:486	arg1	accessibility					488:500	steric accessibility	481:500	steric accessibility	481:500	By mapping steric accessibility, structural rigidity, sequence conservation, and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for structure-based vaccine design.
33793546	1	5	dep	spike	127:131	arg1	S					134:134	S	134:134	S	134:134	The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein.
33793546	6	6	theme	epitope	973:979	arg1	scores					981:986	the stalk overall low epitope scores	951:986	the stalk overall low epitope scores	951:986	The protective glycan shield and the high flexibility of its hinges give the stalk overall low epitope scores.
33793546	3	7	theme	4.1	337:339	arg1	million					341:347	million	341:347	million	341:347	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	3	8	with	patch	374:378	arg1	proteins					460:467	four full-length, fully glycosylated and palmitoylated S proteins	403:467	four full-length, fully glycosylated and palmitoylated S proteins	403:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	1	9	theme	primary	59:65	arg1	target					81:86	The primary immunological target	55:86	The primary immunological target of COVID-19 vaccines	55:107	The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein.
33793546	1	9	theme	primary	59:65	arg1	protein					137:143	the SARS-CoV-2 spike (S) protein	112:143	the SARS-CoV-2 spike (S) protein	112:143	The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein.
33793546	4	10	theme	binding	568:574	arg1	signatures					576:585	generic antibody binding signatures	551:585	generic antibody binding signatures	551:585	By mapping steric accessibility, structural rigidity, sequence conservation, and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for structure-based vaccine design.
33793546	6	11	theme	protective	882:891	arg1	glycan					893:898	The protective glycan shield	878:905	The protective glycan shield	878:905	The protective glycan shield and the high flexibility of its hinges give the stalk overall low epitope scores.
33793546	7	12	theme	envelope	1089:1096	arg1	proteins					1098:1105	other viral envelope proteins	1077:1105	other viral envelope proteins whose structures have been characterized	1077:1146	Our computational epitope-mapping procedure is general and should thus prove useful for other viral envelope proteins whose structures have been characterized.
33793546	1	13	theme	immunological	67:79	arg1	target					81:86	The primary immunological target	55:86	The primary immunological target of COVID-19 vaccines	55:107	The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein.
33793546	1	13	theme	immunological	67:79	arg1	protein					137:143	the SARS-CoV-2 spike (S) protein	112:143	the SARS-CoV-2 spike (S) protein	112:143	The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein.
33793546	5	14	theme	structural	857:866	arg1	dynamics					868:875	structural dynamics	857:875	structural dynamics	857:875	We find that the extensive and inherently flexible glycan coat shields a surface area larger than expected from static structures, highlighting the importance of structural dynamics.
33793546	4	15	theme	promising	630:638	arg1	candidates					648:657	promising epitope candidates	630:657	promising epitope candidates for structure-based vaccine design	630:692	By mapping steric accessibility, structural rigidity, sequence conservation, and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for structure-based vaccine design.
33793546	6	16	theme	low	969:971	arg1	scores					981:986	the stalk overall low epitope scores	951:986	the stalk overall low epitope scores	951:986	The protective glycan shield and the high flexibility of its hinges give the stalk overall low epitope scores.
33793546	6	17	theme	stalk	955:959	arg1	scores					981:986	the stalk overall low epitope scores	951:986	the stalk overall low epitope scores	951:986	The protective glycan shield and the high flexibility of its hinges give the stalk overall low epitope scores.
33793546	3	18	theme	full-length	408:418	arg1	proteins					460:467	four full-length, fully glycosylated and palmitoylated S proteins	403:467	four full-length, fully glycosylated and palmitoylated S proteins	403:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	0	19	theme	epitope	14:20	arg1	map					22:24	Computational epitope map	0:24	Computational epitope map of SARS-CoV-2	0:38	Computational epitope map of SARS-CoV-2 spike protein.
33793546	7	20	theme	other	1077:1081	arg1	proteins					1098:1105	other viral envelope proteins	1077:1105	other viral envelope proteins whose structures have been characterized	1077:1146	Our computational epitope-mapping procedure is general and should thus prove useful for other viral envelope proteins whose structures have been characterized.
33793546	5	21	theme	flexible	737:744	arg1	coat					753:756	the extensive and inherently flexible glycan coat	708:756	the extensive and inherently flexible glycan coat	708:756	We find that the extensive and inherently flexible glycan coat shields a surface area larger than expected from static structures, highlighting the importance of structural dynamics.
33793546	3	22	theme	membrane	389:396	arg1	patch					374:378	a patch	372:378	a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins	372:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	0	23	theme	Computational	0:12	arg1	map					22:24	Computational epitope map	0:24	Computational epitope map of SARS-CoV-2	0:38	Computational epitope map of SARS-CoV-2 spike protein.
33793546	6	24	theme	overall	961:967	arg1	scores					981:986	the stalk overall low epitope scores	951:986	the stalk overall low epitope scores	951:986	The protective glycan shield and the high flexibility of its hinges give the stalk overall low epitope scores.
33793546	7	25	theme	viral	1083:1087	arg1	proteins					1098:1105	other viral envelope proteins	1077:1105	other viral envelope proteins whose structures have been characterized	1077:1146	Our computational epitope-mapping procedure is general and should thus prove useful for other viral envelope proteins whose structures have been characterized.
33793546	3	26	contain	containing	361:370	arg1	system					354:359	a 4.1 million atom system	335:359	a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins	335:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	3	26	contain	containing	361:370	arg2	patch					374:378	a patch	372:378	a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins	372:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	1	27	theme	COVID-19	91:98	arg1	vaccines					100:107	COVID-19 vaccines	91:107	COVID-19 vaccines	91:107	The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein.
33793546	4	28	theme	epitope	640:646	arg1	candidates					648:657	promising epitope candidates	630:657	promising epitope candidates for structure-based vaccine design	630:692	By mapping steric accessibility, structural rigidity, sequence conservation, and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for structure-based vaccine design.
33793546	3	29	theme	million	341:347	arg1	system					354:359	a 4.1 million atom system	335:359	a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins	335:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	4	30	theme	sequence	524:531	arg1	conservation					533:544	sequence conservation	524:544	sequence conservation	524:544	By mapping steric accessibility, structural rigidity, sequence conservation, and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for structure-based vaccine design.
33793546	3	31	theme	possible	237:244	arg1	sites					263:267	possible antibody binding sites	237:267	possible antibody binding sites	237:267	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	1	32	theme	vaccines	100:107	arg1	target					81:86	The primary immunological target	55:86	The primary immunological target of COVID-19 vaccines	55:107	The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein.
33793546	1	32	theme	vaccines	100:107	arg1	protein					137:143	the SARS-CoV-2 spike (S) protein	112:143	the SARS-CoV-2 spike (S) protein	112:143	The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein.
33793546	3	33	theme	glycosylated	427:438	arg1	proteins					460:467	four full-length, fully glycosylated and palmitoylated S proteins	403:467	four full-length, fully glycosylated and palmitoylated S proteins	403:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	3	34	theme	atom	349:352	arg1	system					354:359	a 4.1 million atom system	335:359	a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins	335:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	3	35	theme	antibody	246:253	arg1	sites					263:267	possible antibody binding sites	237:267	possible antibody binding sites	237:267	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	4	36	from	epitopes	605:612	arg1	S					617:617	S	617:617	S	617:617	By mapping steric accessibility, structural rigidity, sequence conservation, and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for structure-based vaccine design.
33793546	0	37	theme	SARS-CoV-2	29:38	arg1	map					22:24	Computational epitope map	0:24	Computational epitope map of SARS-CoV-2	0:38	Computational epitope map of SARS-CoV-2 spike protein.
33793546	4	38	theme	structural	503:512	arg1	rigidity					514:521	structural rigidity	503:521	structural rigidity	503:521	By mapping steric accessibility, structural rigidity, sequence conservation, and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for structure-based vaccine design.
33793546	3	39	theme	viral	383:387	arg1	membrane					389:396	viral membrane	383:396	viral membrane	383:396	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	3	40	gly	glycosylated	427:438	arg1	proteins					460:467	four full-length, fully glycosylated and palmitoylated S proteins	403:467	four full-length, fully glycosylated and palmitoylated S proteins	403:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	7	41	theme	epitope-mapping	1007:1021	arg1	procedure					1023:1031	Our computational epitope-mapping procedure	989:1031	Our computational epitope-mapping procedure	989:1031	Our computational epitope-mapping procedure is general and should thus prove useful for other viral envelope proteins whose structures have been characterized.
33793546	6	42	theme	hinges	939:944	arg1	flexibility					920:930	the high flexibility	911:930	the high flexibility of its hinges	911:944	The protective glycan shield and the high flexibility of its hinges give the stalk overall low epitope scores.
33793546	6	42	theme	hinges	939:944	arg1	glycan					893:898	The protective glycan shield	878:905	The protective glycan shield	878:905	The protective glycan shield and the high flexibility of its hinges give the stalk overall low epitope scores.
33793546	5	43	theme	glycan	746:751	arg1	coat					753:756	the extensive and inherently flexible glycan coat	708:756	the extensive and inherently flexible glycan coat	708:756	We find that the extensive and inherently flexible glycan coat shields a surface area larger than expected from static structures, highlighting the importance of structural dynamics.
33793546	2	44	theme	viral	193:197	arg1	entry					199:203	viral entry	193:203	viral entry into the host cell	193:222	S is exposed on the viral surface and mediates viral entry into the host cell.
33793546	5	45	theme	larger	781:786	arg1	area					776:779	a surface area	766:779	a surface area larger than expected from static structures	766:823	We find that the extensive and inherently flexible glycan coat shields a surface area larger than expected from static structures, highlighting the importance of structural dynamics.
33793546	3	46	theme	binding	255:261	arg1	sites					263:267	possible antibody binding sites	237:267	possible antibody binding sites	237:267	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	6	47	dep	glycan	893:898	arg1	shield					900:905	shield	900:905	shield	900:905	The protective glycan shield and the high flexibility of its hinges give the stalk overall low epitope scores.
33793546	7	48	theme	computational	993:1005	arg1	procedure					1023:1031	Our computational epitope-mapping procedure	989:1031	Our computational epitope-mapping procedure	989:1031	Our computational epitope-mapping procedure is general and should thus prove useful for other viral envelope proteins whose structures have been characterized.
33793546	1	49	theme	spike	127:131	arg1	target					81:86	The primary immunological target	55:86	The primary immunological target of COVID-19 vaccines	55:107	The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein.
33793546	1	49	theme	spike	127:131	arg1	protein					137:143	the SARS-CoV-2 spike (S) protein	112:143	the SARS-CoV-2 spike (S) protein	112:143	The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein.
33793546	5	50	theme	dynamics	868:875	arg1	importance					843:852	the importance	839:852	the importance of structural dynamics	839:875	We find that the extensive and inherently flexible glycan coat shields a surface area larger than expected from static structures, highlighting the importance of structural dynamics.
33793546	2	51	theme	viral	166:170	arg1	surface					172:178	the viral surface	162:178	the viral surface	162:178	S is exposed on the viral surface and mediates viral entry into the host cell.
33793546	5	52	theme	static	807:812	arg1	structures					814:823	static structures	807:823	static structures	807:823	We find that the extensive and inherently flexible glycan coat shields a surface area larger than expected from static structures, highlighting the importance of structural dynamics.
33793546	3	53	theme	S	458:458	arg1	proteins					460:467	four full-length, fully glycosylated and palmitoylated S proteins	403:467	four full-length, fully glycosylated and palmitoylated S proteins	403:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	3	54	theme	palmitoylated	444:456	arg1	proteins					460:467	four full-length, fully glycosylated and palmitoylated S proteins	403:467	four full-length, fully glycosylated and palmitoylated S proteins	403:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	3	55	theme	molecular	301:309	arg1	simulations					320:330	multi-microsecond molecular dynamics simulations	283:330	multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins	283:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	2	56	theme	host	214:217	arg1	cell					219:222	the host cell	210:222	the host cell	210:222	S is exposed on the viral surface and mediates viral entry into the host cell.
33793546	4	57	theme	structure-based	663:677	arg1	design					687:692	structure-based vaccine design	663:692	structure-based vaccine design	663:692	By mapping steric accessibility, structural rigidity, sequence conservation, and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for structure-based vaccine design.
33793546	4	58	theme	known	599:603	arg1	epitopes					605:612	known epitopes	599:612	known epitopes on S	599:617	By mapping steric accessibility, structural rigidity, sequence conservation, and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for structure-based vaccine design.
33793546	3	59	theme	dynamics	311:318	arg1	simulations					320:330	multi-microsecond molecular dynamics simulations	283:330	multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins	283:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	6	60	theme	high	915:918	arg1	flexibility					920:930	the high flexibility	911:930	the high flexibility of its hinges	911:944	The protective glycan shield and the high flexibility of its hinges give the stalk overall low epitope scores.
33793546	5	61	theme	surface	768:774	arg1	area					776:779	a surface area	766:779	a surface area larger than expected from static structures	766:823	We find that the extensive and inherently flexible glycan coat shields a surface area larger than expected from static structures, highlighting the importance of structural dynamics.
33793546	3	62	theme	system	354:359	arg1	simulations					320:330	multi-microsecond molecular dynamics simulations	283:330	multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins	283:467	To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins.
33793546	5	63	theme	extensive	712:720	arg1	coat					753:756	the extensive and inherently flexible glycan coat	708:756	the extensive and inherently flexible glycan coat	708:756	We find that the extensive and inherently flexible glycan coat shields a surface area larger than expected from static structures, highlighting the importance of structural dynamics.
32507174	5	0	theme	less	733:736	arg1	diameter					724:731	an average diameter	713:731	an average diameter less than a micro meter	713:755	The extracted globular shaped CMC crystals had an average diameter less than a micro meter.
32507174	6	1	theme	most	867:870	arg1	biomasses					888:896	most lignocellulosic biomasses	867:896	most lignocellulosic biomasses	867:896	Results revealed that PC leaves are an efficient source of micro-cellulose which result in a high yield than most lignocellulosic biomasses.
32507174	1	2	theme	novel	141:145	arg1	PC					185:186	PC	185:186	PC	185:186	The paper presents a novel candidate plant: Pandanus ceylanicus (PC) for cellulose extraction.
32507174	1	2	theme	novel	141:145	arg1	ceylanicus					173:182	a novel candidate plant: Pandanus ceylanicus	139:182	a novel candidate plant: Pandanus ceylanicus (PC) for cellulose extraction	139:212	The paper presents a novel candidate plant: Pandanus ceylanicus (PC) for cellulose extraction.
32507174	7	3	theme	CMC	1058:1060	arg1	presence					1046:1053	the presence	1042:1053	the presence of CMC	1042:1060	The CMCs were successfully incorporated with nylon 6,10 by in-situ interfacial polymerization of sebacoyl chloride and hexamethylenediamine in the presence of CMC.
32507174	1	4	theme	candidate	147:155	arg1	PC					185:186	PC	185:186	PC	185:186	The paper presents a novel candidate plant: Pandanus ceylanicus (PC) for cellulose extraction.
32507174	1	4	theme	candidate	147:155	arg1	ceylanicus					173:182	a novel candidate plant: Pandanus ceylanicus	139:182	a novel candidate plant: Pandanus ceylanicus (PC) for cellulose extraction	139:212	The paper presents a novel candidate plant: Pandanus ceylanicus (PC) for cellulose extraction.
32507174	5	5	theme	CMC	696:698	arg1	crystals					700:707	The extracted globular shaped CMC crystals	666:707	The extracted globular shaped CMC crystals	666:707	The extracted globular shaped CMC crystals had an average diameter less than a micro meter.
32507174	2	6	theme	Pandanus	309:316	arg1	species					318:324	Pandanus species	309:324	Pandanus species	309:324	The plant showed an average of 91.5 ± 0.2 % of cellulose yield which is the highest yield for Pandanus species reported.
32507174	3	7	theme	extracted	491:499	arg1	fibers					511:516	extracted cellulose fibers	491:516	extracted cellulose fibers with sulphuric acid treatment	491:546	Cellulose was extracted from the leaves of the plant by carrying out alkali and bleaching treatments, and cellulose microcrystals (CMC) were isolated from extracted cellulose fibers with sulphuric acid treatment.
32507174	4	8	theme	treatment	623:631	arg1	stages					613:618	different stages	603:618	different stages of treatment	603:631	Chemical composition of PC leaves was investigated at different stages of treatment by using TAPPI standard methods.
32507174	8	9	theme	retention	1140:1148	arg1	time					1150:1153	low water retention time	1130:1153	low water retention time	1130:1153	The CMC/nylon 6,10 composite showed improved water absorption with low water retention time.
32507174	6	10	theme	high	851:854	arg1	yield					856:860	a high yield	849:860	a high yield than most lignocellulosic biomasses	849:896	Results revealed that PC leaves are an efficient source of micro-cellulose which result in a high yield than most lignocellulosic biomasses.
32507174	2	11	theme	%	257:257	arg1	yield					299:303	the highest yield	287:303	the highest yield for Pandanus species	287:324	The plant showed an average of 91.5 ± 0.2 % of cellulose yield which is the highest yield for Pandanus species reported.
32507174	2	11	theme	%	257:257	arg1	average					235:241	an average	232:241	an average of 91.5 ± 0.2 % of cellulose yield which is the highest yield for Pandanus species	232:324	The plant showed an average of 91.5 ± 0.2 % of cellulose yield which is the highest yield for Pandanus species reported.
32507174	3	12	theme	cellulose	501:509	arg1	fibers					511:516	extracted cellulose fibers	491:516	extracted cellulose fibers with sulphuric acid treatment	491:546	Cellulose was extracted from the leaves of the plant by carrying out alkali and bleaching treatments, and cellulose microcrystals (CMC) were isolated from extracted cellulose fibers with sulphuric acid treatment.
32507174	4	13	theme	Chemical	549:556	arg1	composition					558:568	Chemical composition	549:568	Chemical composition of PC leaves	549:581	Chemical composition of PC leaves was investigated at different stages of treatment by using TAPPI standard methods.
32507174	5	14	contain	had	709:711	arg2	diameter					724:731	an average diameter	713:731	an average diameter less than a micro meter	713:755	The extracted globular shaped CMC crystals had an average diameter less than a micro meter.
32507174	5	14	contain	had	709:711	arg1	crystals					700:707	The extracted globular shaped CMC crystals	666:707	The extracted globular shaped CMC crystals	666:707	The extracted globular shaped CMC crystals had an average diameter less than a micro meter.
32507174	3	15	dep	the	365:367	arg1	leaves					369:374	leaves	369:374	leaves	369:374	Cellulose was extracted from the leaves of the plant by carrying out alkali and bleaching treatments, and cellulose microcrystals (CMC) were isolated from extracted cellulose fibers with sulphuric acid treatment.
32507174	1	16	theme	plant	157:161	arg1	PC					185:186	PC	185:186	PC	185:186	The paper presents a novel candidate plant: Pandanus ceylanicus (PC) for cellulose extraction.
32507174	1	16	theme	plant	157:161	arg1	ceylanicus					173:182	a novel candidate plant: Pandanus ceylanicus	139:182	a novel candidate plant: Pandanus ceylanicus (PC) for cellulose extraction	139:212	The paper presents a novel candidate plant: Pandanus ceylanicus (PC) for cellulose extraction.
32507174	7	17	theme	in-situ	958:964	arg1	polymerization					978:991	in-situ interfacial polymerization	958:991	in-situ interfacial polymerization of sebacoyl chloride and hexamethylenediamine in the presence of CMC	958:1060	The CMCs were successfully incorporated with nylon 6,10 by in-situ interfacial polymerization of sebacoyl chloride and hexamethylenediamine in the presence of CMC.
32507174	3	18	with	fibers	511:516	arg1	treatment					538:546	sulphuric acid treatment	523:546	sulphuric acid treatment	523:546	Cellulose was extracted from the leaves of the plant by carrying out alkali and bleaching treatments, and cellulose microcrystals (CMC) were isolated from extracted cellulose fibers with sulphuric acid treatment.
32507174	8	19	theme	low	1130:1132	arg1	time					1150:1153	low water retention time	1130:1153	low water retention time	1130:1153	The CMC/nylon 6,10 composite showed improved water absorption with low water retention time.
32507174	3	20	theme	sulphuric	523:531	arg1	treatment					538:546	sulphuric acid treatment	523:546	sulphuric acid treatment	523:546	Cellulose was extracted from the leaves of the plant by carrying out alkali and bleaching treatments, and cellulose microcrystals (CMC) were isolated from extracted cellulose fibers with sulphuric acid treatment.
32507174	1	21	theme	Pandanus	164:171	arg1	PC					185:186	PC	185:186	PC	185:186	The paper presents a novel candidate plant: Pandanus ceylanicus (PC) for cellulose extraction.
32507174	1	21	theme	Pandanus	164:171	arg1	ceylanicus					173:182	a novel candidate plant: Pandanus ceylanicus	139:182	a novel candidate plant: Pandanus ceylanicus (PC) for cellulose extraction	139:212	The paper presents a novel candidate plant: Pandanus ceylanicus (PC) for cellulose extraction.
32507174	8	22	theme	6,10	1077:1080	arg1	composite					1082:1090	The CMC/nylon 6,10 composite	1063:1090	The CMC/nylon 6,10 composite	1063:1090	The CMC/nylon 6,10 composite showed improved water absorption with low water retention time.
32507174	3	23	theme	acid	533:536	arg1	treatment					538:546	sulphuric acid treatment	523:546	sulphuric acid treatment	523:546	Cellulose was extracted from the leaves of the plant by carrying out alkali and bleaching treatments, and cellulose microcrystals (CMC) were isolated from extracted cellulose fibers with sulphuric acid treatment.
32507174	8	24	theme	water	1134:1138	arg1	time					1150:1153	low water retention time	1130:1153	low water retention time	1130:1153	The CMC/nylon 6,10 composite showed improved water absorption with low water retention time.
32507174	0	25	theme	microcrystals	23:35	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of cellulose microcrystals (CMC)	0:41	Synthesis of cellulose microcrystals (CMC)/nylon 6,10 composite by incorporating CMC isolated from Pandanus ceylanicus.
32507174	2	26	theme	yield	272:276	arg1	%					257:257	91.5 ± 0.2 %	246:257	91.5 ± 0.2 % of cellulose yield	246:276	The plant showed an average of 91.5 ± 0.2 % of cellulose yield which is the highest yield for Pandanus species reported.
32507174	2	26	theme	yield	272:276	arg1	yield					272:276	cellulose yield	262:276	cellulose yield	262:276	The plant showed an average of 91.5 ± 0.2 % of cellulose yield which is the highest yield for Pandanus species reported.
32507174	0	27	theme	cellulose	13:21	arg1	CMC					38:40	CMC	38:40	CMC	38:40	Synthesis of cellulose microcrystals (CMC)/nylon 6,10 composite by incorporating CMC isolated from Pandanus ceylanicus.
32507174	0	27	theme	cellulose	13:21	arg1	microcrystals					23:35	cellulose microcrystals	13:35	cellulose microcrystals (CMC)	13:41	Synthesis of cellulose microcrystals (CMC)/nylon 6,10 composite by incorporating CMC isolated from Pandanus ceylanicus.
32507174	5	28	theme	extracted	670:678	arg1	crystals					700:707	The extracted globular shaped CMC crystals	666:707	The extracted globular shaped CMC crystals	666:707	The extracted globular shaped CMC crystals had an average diameter less than a micro meter.
32507174	2	29	theme	cellulose	262:270	arg1	yield					272:276	cellulose yield	262:276	cellulose yield	262:276	The plant showed an average of 91.5 ± 0.2 % of cellulose yield which is the highest yield for Pandanus species reported.
32507174	6	30	dep	PC	780:781	arg1	leaves					783:788	leaves	783:788	leaves	783:788	Results revealed that PC leaves are an efficient source of micro-cellulose which result in a high yield than most lignocellulosic biomasses.
32507174	7	31	from	polymerization	978:991	arg1	presence					1046:1053	the presence	1042:1053	the presence of CMC	1042:1060	The CMCs were successfully incorporated with nylon 6,10 by in-situ interfacial polymerization of sebacoyl chloride and hexamethylenediamine in the presence of CMC.
32507174	5	32	theme	globular	680:687	arg1	crystals					700:707	The extracted globular shaped CMC crystals	666:707	The extracted globular shaped CMC crystals	666:707	The extracted globular shaped CMC crystals had an average diameter less than a micro meter.
32507174	6	33	theme	micro-cellulose	817:831	arg1	source					807:812	an efficient source	794:812	an efficient source of micro-cellulose which result in a high yield than most lignocellulosic biomasses	794:896	Results revealed that PC leaves are an efficient source of micro-cellulose which result in a high yield than most lignocellulosic biomasses.
32507174	6	33	theme	micro-cellulose	817:831	arg1	PC					780:781	PC	780:781	PC leaves	780:788	Results revealed that PC leaves are an efficient source of micro-cellulose which result in a high yield than most lignocellulosic biomasses.
32507174	3	34	attach	isolated	477:484	arg2	CMC					467:469	CMC	467:469	CMC	467:469	Cellulose was extracted from the leaves of the plant by carrying out alkali and bleaching treatments, and cellulose microcrystals (CMC) were isolated from extracted cellulose fibers with sulphuric acid treatment.
32507174	3	34	attach	isolated	477:484	arg2	microcrystals					452:464	cellulose microcrystals	442:464	cellulose microcrystals (CMC)	442:470	Cellulose was extracted from the leaves of the plant by carrying out alkali and bleaching treatments, and cellulose microcrystals (CMC) were isolated from extracted cellulose fibers with sulphuric acid treatment.
32507174	3	34	attach	isolated	477:484	arg1	fibers					511:516	extracted cellulose fibers	491:516	extracted cellulose fibers with sulphuric acid treatment	491:546	Cellulose was extracted from the leaves of the plant by carrying out alkali and bleaching treatments, and cellulose microcrystals (CMC) were isolated from extracted cellulose fibers with sulphuric acid treatment.
32507174	2	35	dep	showed	225:230	arg1	reported					326:333	reported	326:333	showed an average of 91.5 ± 0.2 % of cellulose yield which is the highest yield for Pandanus species reported	225:333	The plant showed an average of 91.5 ± 0.2 % of cellulose yield which is the highest yield for Pandanus species reported.
32507174	5	36	theme	micro	745:749	arg1	meter					751:755	a micro meter	743:755	a micro meter	743:755	The extracted globular shaped CMC crystals had an average diameter less than a micro meter.
32507174	4	37	theme	different	603:611	arg1	stages					613:618	different stages	603:618	different stages of treatment	603:631	Chemical composition of PC leaves was investigated at different stages of treatment by using TAPPI standard methods.
32507174	7	38	theme	hexamethylenediamine	1018:1037	arg1	polymerization					978:991	in-situ interfacial polymerization	958:991	in-situ interfacial polymerization of sebacoyl chloride and hexamethylenediamine in the presence of CMC	958:1060	The CMCs were successfully incorporated with nylon 6,10 by in-situ interfacial polymerization of sebacoyl chloride and hexamethylenediamine in the presence of CMC.
32507174	7	39	theme	sebacoyl	996:1003	arg1	chloride					1005:1012	sebacoyl chloride	996:1012	sebacoyl chloride	996:1012	The CMCs were successfully incorporated with nylon 6,10 by in-situ interfacial polymerization of sebacoyl chloride and hexamethylenediamine in the presence of CMC.
32507174	3	40	theme	cellulose	442:450	arg1	CMC					467:469	CMC	467:469	CMC	467:469	Cellulose was extracted from the leaves of the plant by carrying out alkali and bleaching treatments, and cellulose microcrystals (CMC) were isolated from extracted cellulose fibers with sulphuric acid treatment.
32507174	3	40	theme	cellulose	442:450	arg1	microcrystals					452:464	cellulose microcrystals	442:464	cellulose microcrystals (CMC)	442:470	Cellulose was extracted from the leaves of the plant by carrying out alkali and bleaching treatments, and cellulose microcrystals (CMC) were isolated from extracted cellulose fibers with sulphuric acid treatment.
32507174	5	41	theme	shaped	689:694	arg1	crystals					700:707	The extracted globular shaped CMC crystals	666:707	The extracted globular shaped CMC crystals	666:707	The extracted globular shaped CMC crystals had an average diameter less than a micro meter.
32507174	6	42	theme	efficient	797:805	arg1	source					807:812	an efficient source	794:812	an efficient source of micro-cellulose which result in a high yield than most lignocellulosic biomasses	794:896	Results revealed that PC leaves are an efficient source of micro-cellulose which result in a high yield than most lignocellulosic biomasses.
32507174	6	42	theme	efficient	797:805	arg1	PC					780:781	PC	780:781	PC leaves	780:788	Results revealed that PC leaves are an efficient source of micro-cellulose which result in a high yield than most lignocellulosic biomasses.
32507174	7	43	theme	interfacial	966:976	arg1	polymerization					978:991	in-situ interfacial polymerization	958:991	in-situ interfacial polymerization of sebacoyl chloride and hexamethylenediamine in the presence of CMC	958:1060	The CMCs were successfully incorporated with nylon 6,10 by in-situ interfacial polymerization of sebacoyl chloride and hexamethylenediamine in the presence of CMC.
32507174	7	44	theme	chloride	1005:1012	arg1	polymerization					978:991	in-situ interfacial polymerization	958:991	in-situ interfacial polymerization of sebacoyl chloride and hexamethylenediamine in the presence of CMC	958:1060	The CMCs were successfully incorporated with nylon 6,10 by in-situ interfacial polymerization of sebacoyl chloride and hexamethylenediamine in the presence of CMC.
32507174	3	45	dep	alkali	405:410	arg1	treatments					426:435	treatments	426:435	treatments	426:435	Cellulose was extracted from the leaves of the plant by carrying out alkali and bleaching treatments, and cellulose microcrystals (CMC) were isolated from extracted cellulose fibers with sulphuric acid treatment.
32507174	2	46	theme	highest	291:297	arg1	yield					299:303	the highest yield	287:303	the highest yield for Pandanus species	287:324	The plant showed an average of 91.5 ± 0.2 % of cellulose yield which is the highest yield for Pandanus species reported.
32507174	2	46	theme	highest	291:297	arg1	average					235:241	an average	232:241	an average of 91.5 ± 0.2 % of cellulose yield which is the highest yield for Pandanus species	232:324	The plant showed an average of 91.5 ± 0.2 % of cellulose yield which is the highest yield for Pandanus species reported.
32507174	1	47	theme	cellulose	193:201	arg1	extraction					203:212	cellulose extraction	193:212	cellulose extraction	193:212	The paper presents a novel candidate plant: Pandanus ceylanicus (PC) for cellulose extraction.
32507174	8	48	theme	improved	1099:1106	arg1	absorption					1114:1123	improved water absorption	1099:1123	improved water absorption	1099:1123	The CMC/nylon 6,10 composite showed improved water absorption with low water retention time.
32507174	4	49	dep	PC	573:574	arg1	leaves					576:581	leaves	576:581	leaves	576:581	Chemical composition of PC leaves was investigated at different stages of treatment by using TAPPI standard methods.
32507174	8	50	theme	water	1108:1112	arg1	absorption					1114:1123	improved water absorption	1099:1123	improved water absorption	1099:1123	The CMC/nylon 6,10 composite showed improved water absorption with low water retention time.
32507174	4	51	theme	TAPPI	642:646	arg1	methods					657:663	TAPPI standard methods	642:663	TAPPI standard methods	642:663	Chemical composition of PC leaves was investigated at different stages of treatment by using TAPPI standard methods.
32507174	5	52	theme	average	716:722	arg1	diameter					724:731	an average diameter	713:731	an average diameter less than a micro meter	713:755	The extracted globular shaped CMC crystals had an average diameter less than a micro meter.
32507174	0	53	attach	isolated	85:92	arg1	ceylanicus					108:117	Pandanus ceylanicus	99:117	Pandanus ceylanicus	99:117	Synthesis of cellulose microcrystals (CMC)/nylon 6,10 composite by incorporating CMC isolated from Pandanus ceylanicus.
32507174	0	53	attach	isolated	85:92	arg2	CMC					81:83	CMC	81:83	CMC isolated from Pandanus ceylanicus	81:117	Synthesis of cellulose microcrystals (CMC)/nylon 6,10 composite by incorporating CMC isolated from Pandanus ceylanicus.
32507174	4	54	theme	standard	648:655	arg1	methods					657:663	TAPPI standard methods	642:663	TAPPI standard methods	642:663	Chemical composition of PC leaves was investigated at different stages of treatment by using TAPPI standard methods.
32507174	0	55	theme	6,10	49:52	arg1	composite					54:62	6,10 composite	49:62	6,10 composite	49:62	Synthesis of cellulose microcrystals (CMC)/nylon 6,10 composite by incorporating CMC isolated from Pandanus ceylanicus.
32507174	6	56	theme	lignocellulosic	872:886	arg1	biomasses					888:896	most lignocellulosic biomasses	867:896	most lignocellulosic biomasses	867:896	Results revealed that PC leaves are an efficient source of micro-cellulose which result in a high yield than most lignocellulosic biomasses.
32507174	7	57	theme	nylon	944:948	arg1	6,10					950:953	nylon 6,10	944:953	nylon 6,10	944:953	The CMCs were successfully incorporated with nylon 6,10 by in-situ interfacial polymerization of sebacoyl chloride and hexamethylenediamine in the presence of CMC.
32507174	4	58	theme	PC	573:574	arg1	composition					558:568	Chemical composition	549:568	Chemical composition of PC leaves	549:581	Chemical composition of PC leaves was investigated at different stages of treatment by using TAPPI standard methods.
32507174	8	59	theme	CMC/nylon	1067:1075	arg1	composite					1082:1090	The CMC/nylon 6,10 composite	1063:1090	The CMC/nylon 6,10 composite	1063:1090	The CMC/nylon 6,10 composite showed improved water absorption with low water retention time.
33809867	8	0	theme	1655	1586:1589	arg1	cm-1					1591:1594	1655 cm-1	1586:1594	1655 cm-1	1586:1594	The FTIR spectra showed stronger amide peaks at 1535 cm-1 and 1655 cm-1 in membranes with higher concentrated elastin, indicating the incorporation of elastin into electrospun fibers.
33809867	6	1	theme	mass	1260:1263	arg1	loss					1265:1268	mass loss	1260:1268	mass loss	1260:1268	In vitro experiments were conducted to evaluate the degradation in a lysozyme solution based on the mass loss and growth of fibroblastic cells.
33809867	1	2	theme	in	264:265	arg1	studies					285:291	in vitro and in vivo studies	264:291	in vitro and in vivo studies	264:291	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	6	3	dep	loss	1265:1268	arg1	the					1256:1258	the	1256:1258	the	1256:1258	In vitro experiments were conducted to evaluate the degradation in a lysozyme solution based on the mass loss and growth of fibroblastic cells.
33809867	3	4	theme	electrospun	529:539	arg1	membranes					550:558	electrospun chitosan membranes	529:558	electrospun chitosan membranes	529:558	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33809867	7	5	theme	faster	1420:1425	arg1	rates					1439:1443	up to 33% faster degradation rates	1410:1443	up to 33% faster degradation rates	1410:1443	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	7	6	theme	contact	1394:1400	arg1	angles					1402:1407	lower water contact angles	1382:1407	lower water contact angles	1382:1407	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	8	7	from	cm-1	1591:1594	arg1	membranes					1599:1607	membranes	1599:1607	membranes with higher concentrated elastin	1599:1640	The FTIR spectra showed stronger amide peaks at 1535 cm-1 and 1655 cm-1 in membranes with higher concentrated elastin, indicating the incorporation of elastin into electrospun fibers.
33809867	3	8	theme	mechanical	577:586	arg1	strengths					593:601	their mechanical tear strengths	571:601	their mechanical tear strengths	571:601	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33809867	7	9	theme	lower	1382:1386	arg1	angles					1402:1407	lower water contact angles	1382:1407	lower water contact angles	1382:1407	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	10	10	theme	in	1900:1901	arg1	biocompatibility					1909:1924	in vitro biocompatibility	1900:1924	in vitro biocompatibility	1900:1924	In addition, all the CE membranes showed in vitro biocompatibility with the fibroblasts.
33809867	5	11	theme	simulated	1024:1032	arg1	tacking					1043:1049	simulated surgical tacking	1024:1049	simulated surgical tacking	1024:1049	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	6	12	theme	cells	1297:1301	arg1	growth					1274:1279	growth	1274:1279	growth	1274:1279	In vitro experiments were conducted to evaluate the degradation in a lysozyme solution based on the mass loss and growth of fibroblastic cells.
33809867	6	12	theme	cells	1297:1301	arg1	loss					1265:1268	mass loss	1260:1268	mass loss	1260:1268	In vitro experiments were conducted to evaluate the degradation in a lysozyme solution based on the mass loss and growth of fibroblastic cells.
33809867	1	13	from	use	216:218	arg1	applications					248:259	guided bone regeneration applications	223:259	guided bone regeneration applications in in vitro and in vivo studies	223:291	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	0	14	from	Electrospinning	45:59	arg1	Study					2:6	A Study	0:6	A Study of Combining Elastin in the Chitosan Electrospinning	0:59	A Study of Combining Elastin in the Chitosan Electrospinning to Increase the Mechanical Strength and Bioactivity.
33809867	7	15	theme	thicker	1357:1363	arg1	diameters					1371:1379	significantly thicker fiber diameters	1343:1379	significantly thicker fiber diameters	1343:1379	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	1	16	from	applications	248:259	arg1	studies					285:291	in vitro and in vivo studies	264:291	in vitro and in vivo studies	264:291	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	5	17	theme	mechanical	993:1002	arg1	strength					1009:1016	the mechanical tear strength	989:1016	the mechanical tear strength under simulated surgical tacking	989:1049	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	2	18	with	protein	435:441	arg1	property					466:473	extensive elastic property	448:473	extensive elastic property	448:473	Elastin, a natural component of the extracellular matrix, is a protein with extensive elastic property.
33809867	4	19	theme	hydrolyzed	724:733	arg1	elastin					735:741	hydrolyzed elastin	724:741	hydrolyzed elastin (ES12, Elastin Products Company, USA)	724:779	In this work, hydrolyzed elastin (ES12, Elastin Products Company, USA) was added to a chitosan spinning solution from 0 to 4 wt% of chitosan.
33809867	7	20	with	membranes	1313:1321	arg1	elastin					1328:1334	elastin	1328:1334	elastin	1328:1334	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	3	21	theme	native	628:633	arg1	composition					649:659	the native extracellular composition	624:659	the native extracellular composition for guided bone regeneration (GBR) applications	624:707	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33809867	4	22	dep	elastin	735:741	arg1	ES12					744:747	ES12	744:747	ES12	744:747	In this work, hydrolyzed elastin (ES12, Elastin Products Company, USA) was added to a chitosan spinning solution from 0 to 4 wt% of chitosan.
33809867	4	22	dep	elastin	735:741	arg1	USA					776:778	USA	776:778	USA	776:778	In this work, hydrolyzed elastin (ES12, Elastin Products Company, USA) was added to a chitosan spinning solution from 0 to 4 wt% of chitosan.
33809867	4	22	dep	elastin	735:741	arg1	Company					767:773	Elastin Products Company	750:773	Elastin Products Company	750:773	In this work, hydrolyzed elastin (ES12, Elastin Products Company, USA) was added to a chitosan spinning solution from 0 to 4 wt% of chitosan.
33809867	9	23	theme	bicinchoninic	1712:1724	arg1	BCA					1732:1734	BCA	1732:1734	BCA	1732:1734	The bicinchoninic acid (BCA) assay demonstrated an increase in protein concentration in proportion to the amount of elastin added to the CE membranes.
33809867	9	23	theme	bicinchoninic	1712:1724	arg1	acid					1726:1729	bicinchoninic acid	1712:1729	The bicinchoninic acid (BCA) assay	1708:1741	The bicinchoninic acid (BCA) assay demonstrated an increase in protein concentration in proportion to the amount of elastin added to the CE membranes.
33809867	1	24	dep	in	264:265	arg1	vitro					267:271	vitro	267:271	vitro	267:271	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	6	25	from	degradation	1212:1222	arg1	solution					1238:1245	a lysozyme solution	1227:1245	a lysozyme solution based on the mass loss and growth of fibroblastic cells	1227:1301	In vitro experiments were conducted to evaluate the degradation in a lysozyme solution based on the mass loss and growth of fibroblastic cells.
33809867	5	26	theme	infrared	1093:1100	arg1	spectroscopy					1102:1113	Fourier-transform infrared spectroscopy	1075:1113	Fourier-transform infrared spectroscopy (FTIR)	1075:1120	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	5	26	theme	infrared	1093:1100	arg1	FTIR					1116:1119	FTIR	1116:1119	FTIR	1116:1119	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	5	27	theme	chitosan-elastin	856:871	arg1	membranes					878:886	The chitosan-elastin (CE) membranes	852:886	The chitosan-elastin (CE) membranes	852:886	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	4	28	theme	Products	758:765	arg1	ES12					744:747	ES12	744:747	ES12	744:747	In this work, hydrolyzed elastin (ES12, Elastin Products Company, USA) was added to a chitosan spinning solution from 0 to 4 wt% of chitosan.
33809867	4	28	theme	Products	758:765	arg1	Company					767:773	Elastin Products Company	750:773	Elastin Products Company	750:773	In this work, hydrolyzed elastin (ES12, Elastin Products Company, USA) was added to a chitosan spinning solution from 0 to 4 wt% of chitosan.
33809867	0	29	theme	Mechanical	77:86	arg1	Strength					88:95	the Mechanical Strength	73:95	the Mechanical Strength	73:95	A Study of Combining Elastin in the Chitosan Electrospinning to Increase the Mechanical Strength and Bioactivity.
33809867	1	30	theme	collagen	352:359	arg1	membranes					361:369	commercial collagen membranes	341:369	commercial collagen membranes	341:369	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	9	31	dep	amount	1814:1819	arg1	proportion					1796:1805	proportion	1796:1805	proportion	1796:1805	The bicinchoninic acid (BCA) assay demonstrated an increase in protein concentration in proportion to the amount of elastin added to the CE membranes.
33809867	7	32	dep	33	1416:1417	arg1	to					1413:1414	to	1413:1414	to	1413:1414	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	3	33	dep	examined	486:493	arg1	mimic					618:622	mimic	618:622	to further mimic the native extracellular composition for guided bone regeneration (GBR) applications	607:707	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33809867	3	33	dep	examined	486:493	arg1	improve					563:569	improve	563:569	to improve their mechanical tear strengths	560:601	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33809867	0	34	from	Elastin	21:27	arg1	Electrospinning					45:59	the Chitosan Electrospinning	32:59	the Chitosan Electrospinning	32:59	A Study of Combining Elastin in the Chitosan Electrospinning to Increase the Mechanical Strength and Bioactivity.
33809867	1	35	theme	in	277:278	arg1	studies					285:291	in vitro and in vivo studies	264:291	in vitro and in vivo studies	264:291	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	9	36	theme	protein	1771:1777	arg1	concentration					1779:1791	protein concentration	1771:1791	protein concentration	1771:1791	The bicinchoninic acid (BCA) assay demonstrated an increase in protein concentration in proportion to the amount of elastin added to the CE membranes.
33809867	2	37	theme	matrix	422:427	arg1	component					391:399	a natural component	381:399	a natural component of the extracellular matrix	381:427	Elastin, a natural component of the extracellular matrix, is a protein with extensive elastic property.
33809867	2	37	theme	matrix	422:427	arg1	Elastin					372:378	Elastin	372:378	Elastin	372:378	Elastin, a natural component of the extracellular matrix, is a protein with extensive elastic property.
33809867	5	38	theme	fiber	906:910	arg1	morphology					912:921	fiber morphology	906:921	fiber morphology	906:921	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	3	39	theme	guided	665:670	arg1	regeneration					677:688	guided bone regeneration	665:688	guided bone regeneration (GBR) applications	665:707	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33809867	3	39	theme	guided	665:670	arg1	GBR					691:693	GBR	691:693	GBR	691:693	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33809867	0	40	theme	Elastin	21:27	arg1	Study					2:6	A Study	0:6	A Study of Combining Elastin in the Chitosan Electrospinning	0:59	A Study of Combining Elastin in the Chitosan Electrospinning to Increase the Mechanical Strength and Bioactivity.
33809867	2	41	theme	extensive	448:456	arg1	property					466:473	extensive elastic property	448:473	extensive elastic property	448:473	Elastin, a natural component of the extracellular matrix, is a protein with extensive elastic property.
33809867	5	42	theme	post-spinning	1126:1138	arg1	extraction					1148:1157	post-spinning protein extraction	1126:1157	post-spinning protein extraction	1126:1157	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	7	43	theme	higher	1468:1473	arg1	strengths					1486:1494	up to seven times higher mechanical strengths	1450:1494	up to seven times higher mechanical strengths	1450:1494	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	8	44	theme	stronger	1548:1555	arg1	peaks					1563:1567	stronger amide peaks	1548:1567	stronger amide peaks	1548:1567	The FTIR spectra showed stronger amide peaks at 1535 cm-1 and 1655 cm-1 in membranes with higher concentrated elastin, indicating the incorporation of elastin into electrospun fibers.
33809867	1	45	theme	guided	223:228	arg1	applications					248:259	guided bone regeneration applications	223:259	guided bone regeneration applications in in vitro and in vivo studies	223:291	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	9	46	theme	elastin	1824:1830	arg1	elastin					1824:1830	elastin	1824:1830	elastin	1824:1830	The bicinchoninic acid (BCA) assay demonstrated an increase in protein concentration in proportion to the amount of elastin added to the CE membranes.
33809867	9	46	theme	elastin	1824:1830	arg1	amount					1814:1819	the amount	1810:1819	the amount of elastin added to the CE membranes	1810:1856	The bicinchoninic acid (BCA) assay demonstrated an increase in protein concentration in proportion to the amount of elastin added to the CE membranes.
33809867	3	47	theme	regeneration	677:688	arg1	applications					696:707	guided bone regeneration (GBR) applications	665:707	guided bone regeneration (GBR) applications	665:707	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33809867	8	48	theme	higher	1614:1619	arg1	elastin					1634:1640	higher concentrated elastin	1614:1640	higher concentrated elastin	1614:1640	The FTIR spectra showed stronger amide peaks at 1535 cm-1 and 1655 cm-1 in membranes with higher concentrated elastin, indicating the incorporation of elastin into electrospun fibers.
33809867	1	49	theme	regeneration	235:246	arg1	applications					248:259	guided bone regeneration applications	223:259	guided bone regeneration applications in in vitro and in vivo studies	223:291	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	4	50	dep	wt	835:836	arg1	to					830:831	to	830:831	to	830:831	In this work, hydrolyzed elastin (ES12, Elastin Products Company, USA) was added to a chitosan spinning solution from 0 to 4 wt% of chitosan.
33809867	5	51	theme	contact	961:967	arg1	measurements					975:986	water contact angle measurements	955:986	water contact angle measurements	955:986	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	8	52	theme	1535	1572:1575	arg1	cm-1					1577:1580	1535 cm-1	1572:1580	1535 cm-1	1572:1580	The FTIR spectra showed stronger amide peaks at 1535 cm-1 and 1655 cm-1 in membranes with higher concentrated elastin, indicating the incorporation of elastin into electrospun fibers.
33809867	7	53	dep	seven	1456:1460	arg1	to					1453:1454	to	1453:1454	to	1453:1454	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	4	54	theme	4	833:833	arg1	wt					835:836	wt	835:836	wt	835:836	In this work, hydrolyzed elastin (ES12, Elastin Products Company, USA) was added to a chitosan spinning solution from 0 to 4 wt% of chitosan.
33809867	9	55	theme	CE	1845:1846	arg1	membranes					1848:1856	the CE membranes	1841:1856	the CE membranes	1841:1856	The bicinchoninic acid (BCA) assay demonstrated an increase in protein concentration in proportion to the amount of elastin added to the CE membranes.
33809867	3	56	theme	chitosan	541:548	arg1	membranes					550:558	electrospun chitosan membranes	529:558	electrospun chitosan membranes	529:558	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33809867	7	57	theme	degradation	1427:1437	arg1	rates					1439:1443	up to 33% faster degradation rates	1410:1443	up to 33% faster degradation rates	1410:1443	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	6	58	theme	In	1160:1161	arg1	experiments					1169:1179	In vitro experiments	1160:1179	In vitro experiments	1160:1179	In vitro experiments were conducted to evaluate the degradation in a lysozyme solution based on the mass loss and growth of fibroblastic cells.
33809867	10	59	theme	CE	1880:1881	arg1	membranes					1883:1891	all the CE membranes	1872:1891	all the CE membranes	1872:1891	In addition, all the CE membranes showed in vitro biocompatibility with the fibroblasts.
33809867	1	60	theme	nanofibrous	170:180	arg1	morphology					182:191	nanofibrous morphology	170:191	nanofibrous morphology	170:191	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	9	61	from	increase	1759:1766	arg1	concentration					1779:1791	protein concentration	1771:1791	protein concentration	1771:1791	The bicinchoninic acid (BCA) assay demonstrated an increase in protein concentration in proportion to the amount of elastin added to the CE membranes.
33809867	1	62	theme	tear	311:314	arg1	strengths					316:324	their mechanical tear strengths	294:324	their mechanical tear strengths	294:324	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	6	63	theme	lysozyme	1229:1236	arg1	solution					1238:1245	a lysozyme solution	1227:1245	a lysozyme solution based on the mass loss and growth of fibroblastic cells	1227:1301	In vitro experiments were conducted to evaluate the degradation in a lysozyme solution based on the mass loss and growth of fibroblastic cells.
33809867	8	64	theme	elastin	1675:1681	arg1	incorporation					1658:1670	the incorporation	1654:1670	the incorporation of elastin into electrospun fibers	1654:1705	The FTIR spectra showed stronger amide peaks at 1535 cm-1 and 1655 cm-1 in membranes with higher concentrated elastin, indicating the incorporation of elastin into electrospun fibers.
33809867	1	65	dep	in	277:278	arg1	vivo					280:283	vivo	280:283	vivo	280:283	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	4	66	theme	0	828:828	arg1	wt					835:836	wt	835:836	wt	835:836	In this work, hydrolyzed elastin (ES12, Elastin Products Company, USA) was added to a chitosan spinning solution from 0 to 4 wt% of chitosan.
33809867	8	67	from	cm-1	1577:1580	arg1	membranes					1599:1607	membranes	1599:1607	membranes with higher concentrated elastin	1599:1640	The FTIR spectra showed stronger amide peaks at 1535 cm-1 and 1655 cm-1 in membranes with higher concentrated elastin, indicating the incorporation of elastin into electrospun fibers.
33809867	8	68	theme	electrospun	1688:1698	arg1	fibers					1700:1705	electrospun fibers	1688:1705	electrospun fibers	1688:1705	The FTIR spectra showed stronger amide peaks at 1535 cm-1 and 1655 cm-1 in membranes with higher concentrated elastin, indicating the incorporation of elastin into electrospun fibers.
33809867	7	69	theme	water	1388:1392	arg1	angles					1402:1407	lower water contact angles	1382:1407	lower water contact angles	1382:1407	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	5	70	theme	surgical	1034:1041	arg1	tacking					1043:1049	simulated surgical tacking	1024:1049	simulated surgical tacking	1024:1049	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	6	71	dep	In	1160:1161	arg1	vitro					1163:1167	vitro	1163:1167	vitro	1163:1167	In vitro experiments were conducted to evaluate the degradation in a lysozyme solution based on the mass loss and growth of fibroblastic cells.
33809867	1	72	theme	chitosan	132:139	arg1	membranes					141:149	electrospun chitosan membranes	120:149	electrospun chitosan membranes modified to retain nanofibrous morphology	120:191	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	6	73	theme	fibroblastic	1284:1295	arg1	cells					1297:1301	fibroblastic cells	1284:1301	fibroblastic cells	1284:1301	In vitro experiments were conducted to evaluate the degradation in a lysozyme solution based on the mass loss and growth of fibroblastic cells.
33809867	3	74	theme	tear	588:591	arg1	strengths					593:601	their mechanical tear strengths	571:601	their mechanical tear strengths	571:601	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33809867	4	75	theme	chitosan	842:849	arg1	chitosan					842:849	chitosan	842:849	chitosan	842:849	In this work, hydrolyzed elastin (ES12, Elastin Products Company, USA) was added to a chitosan spinning solution from 0 to 4 wt% of chitosan.
33809867	4	75	theme	chitosan	842:849	arg1	%					837:837	0 to 4 wt%	828:837	0 to 4 wt% of chitosan	828:849	In this work, hydrolyzed elastin (ES12, Elastin Products Company, USA) was added to a chitosan spinning solution from 0 to 4 wt% of chitosan.
33809867	7	76	theme	fiber	1365:1369	arg1	diameters					1371:1379	significantly thicker fiber diameters	1343:1379	significantly thicker fiber diameters	1343:1379	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	5	77	theme	tear	1004:1007	arg1	strength					1009:1016	the mechanical tear strength	989:1016	the mechanical tear strength under simulated surgical tacking	989:1049	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	1	78	theme	electrospun	120:130	arg1	membranes					141:149	electrospun chitosan membranes	120:149	electrospun chitosan membranes modified to retain nanofibrous morphology	120:191	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	9	79	theme	acid	1726:1729	arg1	assay					1737:1741	The bicinchoninic acid (BCA) assay	1708:1741	The bicinchoninic acid (BCA) assay	1708:1741	The bicinchoninic acid (BCA) assay demonstrated an increase in protein concentration in proportion to the amount of elastin added to the CE membranes.
33809867	0	80	from	Study	2:6	arg1	Electrospinning					45:59	the Chitosan Electrospinning	32:59	the Chitosan Electrospinning	32:59	A Study of Combining Elastin in the Chitosan Electrospinning to Increase the Mechanical Strength and Bioactivity.
33809867	1	81	theme	commercial	341:350	arg1	membranes					361:369	commercial collagen membranes	341:369	commercial collagen membranes	341:369	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	10	82	dep	in	1900:1901	arg1	vitro					1903:1907	vitro	1903:1907	vitro	1903:1907	In addition, all the CE membranes showed in vitro biocompatibility with the fibroblasts.
33809867	4	83	theme	Elastin	750:756	arg1	Products					758:765	Elastin Products	750:765	Elastin Products Company	750:773	In this work, hydrolyzed elastin (ES12, Elastin Products Company, USA) was added to a chitosan spinning solution from 0 to 4 wt% of chitosan.
33809867	7	84	theme	Chitosan	1304:1311	arg1	membranes					1313:1321	Chitosan membranes	1304:1321	Chitosan membranes with elastin	1304:1334	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	2	85	theme	natural	383:389	arg1	component					391:399	a natural component	381:399	a natural component of the extracellular matrix	381:427	Elastin, a natural component of the extracellular matrix, is a protein with extensive elastic property.
33809867	2	85	theme	natural	383:389	arg1	Elastin					372:378	Elastin	372:378	Elastin	372:378	Elastin, a natural component of the extracellular matrix, is a protein with extensive elastic property.
33809867	5	86	theme	Fourier-transform	1075:1091	arg1	spectroscopy					1102:1113	Fourier-transform infrared spectroscopy	1075:1113	Fourier-transform infrared spectroscopy (FTIR)	1075:1120	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	5	86	theme	Fourier-transform	1075:1091	arg1	FTIR					1116:1119	FTIR	1116:1119	FTIR	1116:1119	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	0	87	theme	Combining	11:19	arg1	Elastin					21:27	Combining Elastin	11:27	Combining Elastin in the Chitosan Electrospinning	11:59	A Study of Combining Elastin in the Chitosan Electrospinning to Increase the Mechanical Strength and Bioactivity.
33809867	8	88	theme	FTIR	1528:1531	arg1	spectra					1533:1539	The FTIR spectra	1524:1539	The FTIR spectra	1524:1539	The FTIR spectra showed stronger amide peaks at 1535 cm-1 and 1655 cm-1 in membranes with higher concentrated elastin, indicating the incorporation of elastin into electrospun fibers.
33809867	2	89	theme	extracellular	408:420	arg1	matrix					422:427	the extracellular matrix	404:427	the extracellular matrix	404:427	Elastin, a natural component of the extracellular matrix, is a protein with extensive elastic property.
33809867	7	90	theme	chitosan	1505:1512	arg1	membrane					1514:1521	the chitosan membrane	1501:1521	the chitosan membrane	1501:1521	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	5	91	theme	angle	969:973	arg1	measurements					975:986	water contact angle measurements	955:986	water contact angle measurements	955:986	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	2	92	theme	elastic	458:464	arg1	property					466:473	extensive elastic property	448:473	extensive elastic property	448:473	Elastin, a natural component of the extracellular matrix, is a protein with extensive elastic property.
33809867	8	93	with	membranes	1599:1607	arg1	elastin					1634:1640	higher concentrated elastin	1614:1640	higher concentrated elastin	1614:1640	The FTIR spectra showed stronger amide peaks at 1535 cm-1 and 1655 cm-1 in membranes with higher concentrated elastin, indicating the incorporation of elastin into electrospun fibers.
33809867	3	94	theme	extracellular	635:647	arg1	composition					649:659	the native extracellular composition	624:659	the native extracellular composition for guided bone regeneration (GBR) applications	624:707	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33809867	0	95	theme	Chitosan	36:43	arg1	Electrospinning					45:59	the Chitosan Electrospinning	32:59	the Chitosan Electrospinning	32:59	A Study of Combining Elastin in the Chitosan Electrospinning to Increase the Mechanical Strength and Bioactivity.
33809867	1	96	theme	mechanical	300:309	arg1	strengths					316:324	their mechanical tear strengths	294:324	their mechanical tear strengths	294:324	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	8	97	theme	amide	1557:1561	arg1	peaks					1563:1567	stronger amide peaks	1548:1567	stronger amide peaks	1548:1567	The FTIR spectra showed stronger amide peaks at 1535 cm-1 and 1655 cm-1 in membranes with higher concentrated elastin, indicating the incorporation of elastin into electrospun fibers.
33809867	5	98	theme	protein	1140:1146	arg1	extraction					1148:1157	post-spinning protein extraction	1126:1157	post-spinning protein extraction	1126:1157	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	7	99	theme	mechanical	1475:1484	arg1	strengths					1486:1494	up to seven times higher mechanical strengths	1450:1494	up to seven times higher mechanical strengths	1450:1494	Chitosan membranes with elastin showed significantly thicker fiber diameters, lower water contact angles, up to 33% faster degradation rates, and up to seven times higher mechanical strengths than the chitosan membrane.
33809867	3	100	theme	bone	672:675	arg1	regeneration					677:688	guided bone regeneration	665:688	guided bone regeneration (GBR) applications	665:707	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33809867	3	100	theme	bone	672:675	arg1	GBR					691:693	GBR	691:693	GBR	691:693	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33809867	8	101	theme	concentrated	1621:1632	arg1	elastin					1634:1640	higher concentrated elastin	1614:1640	higher concentrated elastin	1614:1640	The FTIR spectra showed stronger amide peaks at 1535 cm-1 and 1655 cm-1 in membranes with higher concentrated elastin, indicating the incorporation of elastin into electrospun fibers.
33809867	1	102	theme	bone	230:233	arg1	applications					248:259	guided bone regeneration applications	223:259	guided bone regeneration applications in in vitro and in vivo studies	223:291	While electrospun chitosan membranes modified to retain nanofibrous morphology have shown promise for use in guided bone regeneration applications in in vitro and in vivo studies, their mechanical tear strengths are lower than commercial collagen membranes.
33809867	5	103	theme	water	955:959	arg1	measurements					975:986	water contact angle measurements	955:986	water contact angle measurements	955:986	The chitosan-elastin (CE) membranes were examined for fiber morphology using SEM, hydrophobicity using water contact angle measurements, the mechanical tear strength under simulated surgical tacking, and compositions using Fourier-transform infrared spectroscopy (FTIR) and post-spinning protein extraction.
33809867	3	104	theme	elastin	516:522	arg1	incorporation					499:511	the incorporation	495:511	the incorporation of elastin into electrospun chitosan membranes	495:558	This work examined the incorporation of elastin into electrospun chitosan membranes to improve their mechanical tear strengths and to further mimic the native extracellular composition for guided bone regeneration (GBR) applications.
33181207	0	0	theme	subsequent	97:106	arg1	absorber					118:125	subsequent microwave absorber	97:125	subsequent microwave absorber	97:125	Multistage reclamation of Co2+-containing alginate hydrogels as excellent reduction catalyst and subsequent microwave absorber by facile transformation.
33181207	5	1	theme	doped	896:900	arg1	species					915:921	doped heteroatom N species	896:921	doped heteroatom N species	896:921	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	1	theme	doped	896:900	arg1	network					858:864	unique 3D interconnected network	833:864	unique 3D interconnected network	833:864	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	1	2	theme	materials	183:191	arg1	reclamation					168:178	The multistage reclamation	153:178	The multistage reclamation of materials	153:191	The multistage reclamation of materials has made contributions to sustainable development, but further progress is still sought after.
33181207	5	3	theme	heteroatom	902:911	arg1	species					915:921	doped heteroatom N species	896:921	doped heteroatom N species	896:921	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	3	theme	heteroatom	902:911	arg1	network					858:864	unique 3D interconnected network	833:864	unique 3D interconnected network	833:864	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	4	theme	prominent	1046:1054	arg1	performance					1077:1087	prominent microwave absorption performance	1046:1087	prominent microwave absorption performance	1046:1087	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	5	from	6.4 GHz	1115:1121	arg1	-54.2 dB					1094:1101	-54.2 dB	1094:1101	-54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz)	1094:1189	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	6	theme	interconnected	843:856	arg1	network					858:864	unique 3D interconnected network	833:864	unique 3D interconnected network	833:864	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	6	theme	interconnected	843:856	arg1	interfaces					881:890	heterogeneous interfaces	867:890	heterogeneous interfaces	867:890	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	6	theme	interconnected	843:856	arg1	species					915:921	doped heteroatom N species	896:921	doped heteroatom N species	896:921	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	7	7	theme	other	1530:1534	arg1	products					1536:1543	other products	1530:1543	other products	1530:1543	This work provided a novel idea for designing biomass-based functional materials and simultaneously achieved economic benefits through the rational utilization of other products in the preparation process.
33181207	2	8	theme	seaweed-based	317:329	arg1	composites					331:340	functionalized seaweed-based composites	302:340	functionalized seaweed-based composites	302:340	In this work, functionalized seaweed-based composites were successfully prepared and utilized in multiple stages.
33181207	0	9	theme	microwave	108:116	arg1	absorber					118:125	subsequent microwave absorber	97:125	subsequent microwave absorber	97:125	Multistage reclamation of Co2+-containing alginate hydrogels as excellent reduction catalyst and subsequent microwave absorber by facile transformation.
33181207	3	10	theme	p-nitrophenol	635:647	arg1	reduction					622:630	efficient reduction	612:630	efficient reduction of p-nitrophenol	612:647	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	2	11	theme	functionalized	302:315	arg1	composites					331:340	functionalized seaweed-based composites	302:340	functionalized seaweed-based composites	302:340	In this work, functionalized seaweed-based composites were successfully prepared and utilized in multiple stages.
33181207	4	12	theme	carbonization	688:700	arg1	procedures					702:711	carbonization procedures	688:711	carbonization procedures	688:711	After coupling with freeze-drying and carbonization procedures, a high-performance Co/N co-doped carbonaceous microwave absorber was obtained and investigated in detail.
33181207	0	13	theme	facile	130:135	arg1	transformation					137:150	facile transformation	130:150	facile transformation	130:150	Multistage reclamation of Co2+-containing alginate hydrogels as excellent reduction catalyst and subsequent microwave absorber by facile transformation.
33181207	5	14	theme	microwave	1056:1064	arg1	performance					1077:1087	prominent microwave absorption performance	1046:1087	prominent microwave absorption performance	1046:1087	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	15	theme	optimal	960:966	arg1	impedance					968:976	optimal impedance matching	960:985	optimal impedance matching	960:985	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	4	16	theme	co-doped	738:745	arg1	absorber					770:777	a high-performance Co/N co-doped carbonaceous microwave absorber	714:777	a high-performance Co/N co-doped carbonaceous microwave absorber	714:777	After coupling with freeze-drying and carbonization procedures, a high-performance Co/N co-doped carbonaceous microwave absorber was obtained and investigated in detail.
33181207	3	17	theme	efficient	612:620	arg1	reduction					622:630	efficient reduction	612:630	efficient reduction of p-nitrophenol	612:647	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	7	18	theme	rational	1506:1513	arg1	utilization					1515:1525	the rational utilization	1502:1525	the rational utilization of other products in the preparation process	1502:1570	This work provided a novel idea for designing biomass-based functional materials and simultaneously achieved economic benefits through the rational utilization of other products in the preparation process.
33181207	5	19	theme	heterogeneous	867:879	arg1	network					858:864	unique 3D interconnected network	833:864	unique 3D interconnected network	833:864	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	19	theme	heterogeneous	867:879	arg1	interfaces					881:890	heterogeneous interfaces	867:890	heterogeneous interfaces	867:890	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	4	20	with	coupling	656:663	arg1	freeze-drying					670:682	freeze-drying	670:682	freeze-drying	670:682	After coupling with freeze-drying and carbonization procedures, a high-performance Co/N co-doped carbonaceous microwave absorber was obtained and investigated in detail.
33181207	4	20	with	coupling	656:663	arg1	procedures					702:711	carbonization procedures	688:711	carbonization procedures	688:711	After coupling with freeze-drying and carbonization procedures, a high-performance Co/N co-doped carbonaceous microwave absorber was obtained and investigated in detail.
33181207	6	21	theme	functional	1294:1303	arg1	components					1305:1314	the functional components	1290:1314	the functional components	1290:1314	Additionally, in view of the dielectric loss and magnetic loss caused by the synergy effect among the functional components, the underlying absorption mechanism was proposed.
33181207	6	22	theme	dielectric	1221:1230	arg1	loss					1232:1235	dielectric loss	1221:1235	dielectric loss	1221:1235	Additionally, in view of the dielectric loss and magnetic loss caused by the synergy effect among the functional components, the underlying absorption mechanism was proposed.
33181207	3	23	theme	adsorption	500:509	arg1	method					511:516	adsorption method	500:516	adsorption method	500:516	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	2	24	used	utilized	373:380	arg2	composites					331:340	functionalized seaweed-based composites	302:340	functionalized seaweed-based composites	302:340	In this work, functionalized seaweed-based composites were successfully prepared and utilized in multiple stages.
33181207	3	25	theme	sol-gel	474:480	arg1	self-assembly					482:494	sol-gel self-assembly	474:494	sol-gel self-assembly	474:494	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	0	26	theme	Multistage	0:9	arg1	reclamation					11:21	Multistage reclamation	0:21	Multistage reclamation of Co2+-containing alginate	0:49	Multistage reclamation of Co2+-containing alginate hydrogels as excellent reduction catalyst and subsequent microwave absorber by facile transformation.
33181207	5	27	with	absorber	946:953	arg1	impedance					968:976	optimal impedance matching	960:985	optimal impedance matching	960:985	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	1	28	theme	sustainable	219:229	arg1	development					231:241	sustainable development	219:241	sustainable development	219:241	The multistage reclamation of materials has made contributions to sustainable development, but further progress is still sought after.
33181207	0	29	theme	Co2+-containing	26:40	arg1	alginate					42:49	Co2+-containing alginate	26:49	Co2+-containing alginate	26:49	Multistage reclamation of Co2+-containing alginate hydrogels as excellent reduction catalyst and subsequent microwave absorber by facile transformation.
33181207	6	30	theme	absorption	1332:1341	arg1	mechanism					1343:1351	the underlying absorption mechanism	1317:1351	the underlying absorption mechanism	1317:1351	Additionally, in view of the dielectric loss and magnetic loss caused by the synergy effect among the functional components, the underlying absorption mechanism was proposed.
33181207	7	31	from	utilization	1515:1525	arg1	process					1564:1570	the preparation process	1548:1570	the preparation process	1548:1570	This work provided a novel idea for designing biomass-based functional materials and simultaneously achieved economic benefits through the rational utilization of other products in the preparation process.
33181207	5	32	theme	RLmin	1106:1110	arg1	-54.2 dB					1094:1101	-54.2 dB	1094:1101	-54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz)	1094:1189	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	33	from	18.0 GHz	1181:1188	arg1	bandwidth					1157:1165	maximum absorption bandwidth	1138:1165	maximum absorption bandwidth (from 12.7 to 18.0 GHz)	1138:1189	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	3	34	theme	interior/exterior	524:540	arg1	alginate					568:575	interior/exterior co-functionalized calcium alginate	524:575	interior/exterior co-functionalized calcium alginate	524:575	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	3	34	theme	interior/exterior	524:540	arg1	materials					584:592	raw materials	580:592	raw materials	580:592	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	3	35	theme	alginate	432:439	arg1	hydrogels					441:449	Co2+-containing alginate hydrogels	416:449	Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials	416:592	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	3	35	theme	alginate	432:439	arg1	CHB-Co2+					452:459	CHB-Co2+	452:459	CHB-Co2+	452:459	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	6	36	theme	synergy	1269:1275	arg1	effect					1277:1282	the synergy effect	1265:1282	the synergy effect among the functional components	1265:1314	Additionally, in view of the dielectric loss and magnetic loss caused by the synergy effect among the functional components, the underlying absorption mechanism was proposed.
33181207	3	37	theme	co-functionalized	542:558	arg1	alginate					568:575	interior/exterior co-functionalized calcium alginate	524:575	interior/exterior co-functionalized calcium alginate	524:575	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	3	37	theme	co-functionalized	542:558	arg1	materials					584:592	raw materials	580:592	raw materials	580:592	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	5	38	theme	N	913:913	arg1	species					915:921	doped heteroatom N species	896:921	doped heteroatom N species	896:921	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	38	theme	N	913:913	arg1	network					858:864	unique 3D interconnected network	833:864	unique 3D interconnected network	833:864	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	39	theme	absorption	1066:1075	arg1	performance					1077:1087	prominent microwave absorption performance	1046:1087	prominent microwave absorption performance	1046:1087	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	40	theme	unique	833:838	arg1	network					858:864	unique 3D interconnected network	833:864	unique 3D interconnected network	833:864	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	40	theme	unique	833:838	arg1	interfaces					881:890	heterogeneous interfaces	867:890	heterogeneous interfaces	867:890	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	40	theme	unique	833:838	arg1	species					915:921	doped heteroatom N species	896:921	doped heteroatom N species	896:921	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	7	41	theme	novel	1388:1392	arg1	idea					1394:1397	a novel idea	1386:1397	a novel idea for designing biomass-based functional materials	1386:1446	This work provided a novel idea for designing biomass-based functional materials and simultaneously achieved economic benefits through the rational utilization of other products in the preparation process.
33181207	6	42	dep	loss	1232:1235	arg1	the					1217:1219	the	1217:1219	the	1217:1219	Additionally, in view of the dielectric loss and magnetic loss caused by the synergy effect among the functional components, the underlying absorption mechanism was proposed.
33181207	0	43	theme	alginate	42:49	arg1	reclamation					11:21	Multistage reclamation	0:21	Multistage reclamation of Co2+-containing alginate	0:49	Multistage reclamation of Co2+-containing alginate hydrogels as excellent reduction catalyst and subsequent microwave absorber by facile transformation.
33181207	5	44	theme	3D	840:841	arg1	network					858:864	unique 3D interconnected network	833:864	unique 3D interconnected network	833:864	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	44	theme	3D	840:841	arg1	interfaces					881:890	heterogeneous interfaces	867:890	heterogeneous interfaces	867:890	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	44	theme	3D	840:841	arg1	species					915:921	doped heteroatom N species	896:921	doped heteroatom N species	896:921	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	45	theme	network	858:864	arg1	virtue					823:828	virtue	823:828	virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability	823:1009	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	3	46	theme	Co2+-containing	416:430	arg1	hydrogels					441:449	Co2+-containing alginate hydrogels	416:449	Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials	416:592	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	3	46	theme	Co2+-containing	416:430	arg1	CHB-Co2+					452:459	CHB-Co2+	452:459	CHB-Co2+	452:459	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	5	47	theme	matching	978:985	arg1	impedance					968:976	optimal impedance matching	960:985	optimal impedance matching	960:985	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	1	48	theme	further	248:254	arg1	progress					256:263	further progress	248:263	further progress	248:263	The multistage reclamation of materials has made contributions to sustainable development, but further progress is still sought after.
33181207	0	49	theme	excellent	64:72	arg1	catalyst					84:91	excellent reduction catalyst	64:91	excellent reduction catalyst	64:91	Multistage reclamation of Co2+-containing alginate hydrogels as excellent reduction catalyst and subsequent microwave absorber by facile transformation.
33181207	5	50	with	ability	1003:1009	arg1	impedance					968:976	optimal impedance matching	960:985	optimal impedance matching	960:985	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	7	51	theme	products	1536:1543	arg1	utilization					1515:1525	the rational utilization	1502:1525	the rational utilization of other products in the preparation process	1502:1570	This work provided a novel idea for designing biomass-based functional materials and simultaneously achieved economic benefits through the rational utilization of other products in the preparation process.
33181207	6	52	theme	magnetic	1241:1248	arg1	loss					1250:1253	magnetic loss	1241:1253	magnetic loss	1241:1253	Additionally, in view of the dielectric loss and magnetic loss caused by the synergy effect among the functional components, the underlying absorption mechanism was proposed.
33181207	2	53	theme	multiple	385:392	arg1	stages					394:399	multiple stages	385:399	multiple stages	385:399	In this work, functionalized seaweed-based composites were successfully prepared and utilized in multiple stages.
33181207	6	54	theme	loss	1232:1235	arg1	view					1209:1212	view	1209:1212	view of the dielectric loss and magnetic loss caused by the synergy effect among the functional components	1209:1314	Additionally, in view of the dielectric loss and magnetic loss caused by the synergy effect among the functional components, the underlying absorption mechanism was proposed.
33181207	7	55	theme	biomass-based	1413:1425	arg1	materials					1438:1446	biomass-based functional materials	1413:1446	biomass-based functional materials	1413:1446	This work provided a novel idea for designing biomass-based functional materials and simultaneously achieved economic benefits through the rational utilization of other products in the preparation process.
33181207	3	56	theme	raw	580:582	arg1	alginate					568:575	interior/exterior co-functionalized calcium alginate	524:575	interior/exterior co-functionalized calcium alginate	524:575	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	3	56	theme	raw	580:582	arg1	materials					584:592	raw materials	580:592	raw materials	580:592	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	6	57	theme	underlying	1321:1330	arg1	mechanism					1343:1351	the underlying absorption mechanism	1317:1351	the underlying absorption mechanism	1317:1351	Additionally, in view of the dielectric loss and magnetic loss caused by the synergy effect among the functional components, the underlying absorption mechanism was proposed.
33181207	5	58	theme	maximum	1138:1144	arg1	bandwidth					1157:1165	maximum absorption bandwidth	1138:1165	maximum absorption bandwidth (from 12.7 to 18.0 GHz)	1138:1189	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	7	59	theme	preparation	1552:1562	arg1	process					1564:1570	the preparation process	1548:1570	the preparation process	1548:1570	This work provided a novel idea for designing biomass-based functional materials and simultaneously achieved economic benefits through the rational utilization of other products in the preparation process.
33181207	3	60	theme	calcium	560:566	arg1	alginate					568:575	interior/exterior co-functionalized calcium alginate	524:575	interior/exterior co-functionalized calcium alginate	524:575	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	3	60	theme	calcium	560:566	arg1	materials					584:592	raw materials	580:592	raw materials	580:592	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	5	61	dep	18.0 GHz	1181:1188	arg1	to					1178:1179	to	1178:1179	to	1178:1179	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	6	62	theme	loss	1250:1253	arg1	view					1209:1212	view	1209:1212	view of the dielectric loss and magnetic loss caused by the synergy effect among the functional components	1209:1314	Additionally, in view of the dielectric loss and magnetic loss caused by the synergy effect among the functional components, the underlying absorption mechanism was proposed.
33181207	7	63	theme	functional	1427:1436	arg1	materials					1438:1446	biomass-based functional materials	1413:1446	biomass-based functional materials	1413:1446	This work provided a novel idea for designing biomass-based functional materials and simultaneously achieved economic benefits through the rational utilization of other products in the preparation process.
33181207	5	64	theme	absorption	1146:1155	arg1	bandwidth					1157:1165	maximum absorption bandwidth	1138:1165	maximum absorption bandwidth (from 12.7 to 18.0 GHz)	1138:1189	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	1	65	theme	multistage	157:166	arg1	reclamation					168:178	The multistage reclamation	153:178	The multistage reclamation of materials	153:191	The multistage reclamation of materials has made contributions to sustainable development, but further progress is still sought after.
33181207	7	66	theme	economic	1476:1483	arg1	benefits					1485:1492	economic benefits	1476:1492	economic benefits	1476:1492	This work provided a novel idea for designing biomass-based functional materials and simultaneously achieved economic benefits through the rational utilization of other products in the preparation process.
33181207	4	67	theme	microwave	760:768	arg1	absorber					770:777	a high-performance Co/N co-doped carbonaceous microwave absorber	714:777	a high-performance Co/N co-doped carbonaceous microwave absorber	714:777	After coupling with freeze-drying and carbonization procedures, a high-performance Co/N co-doped carbonaceous microwave absorber was obtained and investigated in detail.
33181207	5	68	theme	bandwidth	1157:1165	arg1	bandwidth					1157:1165	maximum absorption bandwidth	1138:1165	maximum absorption bandwidth (from 12.7 to 18.0 GHz)	1138:1189	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	68	theme	bandwidth	1157:1165	arg1	6.4 GHz					1115:1121	6.4 GHz	1115:1121	6.4 GHz	1115:1121	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	4	69	theme	carbonaceous	747:758	arg1	absorber					770:777	a high-performance Co/N co-doped carbonaceous microwave absorber	714:777	a high-performance Co/N co-doped carbonaceous microwave absorber	714:777	After coupling with freeze-drying and carbonization procedures, a high-performance Co/N co-doped carbonaceous microwave absorber was obtained and investigated in detail.
33181207	5	70	theme	as-fabricated	1012:1024	arg1	NC-Co-700					1026:1034	as-fabricated NC-Co-700	1012:1034	as-fabricated NC-Co-700	1012:1034	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	5	71	theme	attenuation	991:1001	arg1	ability					1003:1009	attenuation ability	991:1009	attenuation ability	991:1009	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	4	72	theme	Co/N	733:736	arg1	absorber					770:777	a high-performance Co/N co-doped carbonaceous microwave absorber	714:777	a high-performance Co/N co-doped carbonaceous microwave absorber	714:777	After coupling with freeze-drying and carbonization procedures, a high-performance Co/N co-doped carbonaceous microwave absorber was obtained and investigated in detail.
33181207	0	73	theme	reduction	74:82	arg1	catalyst					84:91	excellent reduction catalyst	64:91	excellent reduction catalyst	64:91	Multistage reclamation of Co2+-containing alginate hydrogels as excellent reduction catalyst and subsequent microwave absorber by facile transformation.
33181207	3	74	used	utilized	599:606	arg2	CHB-Co2+					452:459	CHB-Co2+	452:459	CHB-Co2+	452:459	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	3	74	used	utilized	599:606	arg2	hydrogels					441:449	Co2+-containing alginate hydrogels	416:449	Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials	416:592	Specifically, Co2+-containing alginate hydrogels (CHB-Co2+) prepared by sol-gel self-assembly and adsorption method using interior/exterior co-functionalized calcium alginate as raw materials were utilized for efficient reduction of p-nitrophenol.
33181207	5	75	from	5.3 GHz	1127:1133	arg1	-54.2 dB					1094:1101	-54.2 dB	1094:1101	-54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz)	1094:1189	By virtue of unique 3D interconnected network, heterogeneous interfaces and doped heteroatom N species, by which endowing the absorber with optimal impedance matching and attenuation ability, as-fabricated NC-Co-700 exhibited prominent microwave absorption performance with -54.2 dB of RLmin at 6.4 GHz and 5.3 GHz of maximum absorption bandwidth (from 12.7 to 18.0 GHz).
33181207	4	76	theme	high-performance	716:731	arg1	absorber					770:777	a high-performance Co/N co-doped carbonaceous microwave absorber	714:777	a high-performance Co/N co-doped carbonaceous microwave absorber	714:777	After coupling with freeze-drying and carbonization procedures, a high-performance Co/N co-doped carbonaceous microwave absorber was obtained and investigated in detail.
32567143	1	0	used	used	250:253	arg2	PSC					184:186	PSC	184:186	PSC	184:186	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	0	used	used	250:253	arg2	collagen					174:181	Pepsin soluble collagen	159:181	Pepsin soluble collagen (PSC)	159:187	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	3	1	theme	clear	857:861	arg1	dependence					881:890	no clear PSC concentration dependence	854:890	no clear PSC concentration dependence	854:890	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	2	2	contain	containing	612:621	arg2	PSC					636:638	PSC	636:638	PSC	636:638	Results show that coating by 1% of chitosan solutions containing 0.0%-0.8% of PSC significantly improved most deterioration indexes.
32567143	2	2	contain	containing	612:621	arg2	%					631:631	0.0%-0.8%	623:631	0.0%-0.8% of PSC	623:638	Results show that coating by 1% of chitosan solutions containing 0.0%-0.8% of PSC significantly improved most deterioration indexes.
32567143	2	2	contain	containing	612:621	arg1	solutions					602:610	chitosan solutions	593:610	chitosan solutions containing 0.0%-0.8% of PSC	593:638	Results show that coating by 1% of chitosan solutions containing 0.0%-0.8% of PSC significantly improved most deterioration indexes.
32567143	8	3	theme	product	1516:1522	arg1	collagen					1487:1494	Pepsin soluble collagen	1472:1494	Pepsin soluble collagen (PSC)	1472:1500	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	8	3	theme	product	1516:1522	arg1	by-product					1535:1544	an aquatic product processing by-product	1505:1544	an aquatic product processing by-product that makes the maximum use of resources	1505:1584	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	1	4	theme	glauca	229:234	arg1	skin					237:240	blue shark (Prionace glauca) skin	208:240	blue shark (Prionace glauca) skin	208:240	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	3	5	contain	containing	726:735	arg1	solution					717:724	chitosan solution	708:724	chitosan solution containing 0.8% of PSC	708:747	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	3	5	contain	containing	726:735	arg2	%					740:740	0.8%	737:740	0.8% of PSC	737:747	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	3	5	contain	containing	726:735	arg2	PSC					745:747	PSC	745:747	PSC	745:747	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	4	6	theme	PSC	959:961	arg1	%					954:954	0.8%	951:954	0.8% of PSC	951:961	These results indicate 1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study.
32567143	4	6	theme	PSC	959:961	arg1	formulation					983:993	the best coating formulation	966:993	the best coating formulation examined in this study	966:1016	These results indicate 1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study.
32567143	4	6	theme	PSC	959:961	arg1	PSC					959:961	PSC	959:961	PSC	959:961	These results indicate 1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study.
32567143	10	7	theme	edible	1761:1766	arg1	formulation					1776:1786	A more high-quality and effective edible coating formulation	1727:1786	A more high-quality and effective edible coating formulation	1727:1786	A more high-quality and effective edible coating formulation was obtained, thereby extending the red porgy fillet shelf life.
32567143	1	8	theme	volatile	404:411	arg1	indexes					549:555	deterioration indexes	535:555	deterioration indexes	535:555	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	8	theme	volatile	404:411	arg1	scores					511:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	9	9	theme	composite	1610:1618	arg1	formulation					1620:1630	a composite formulation	1608:1630	a composite formulation comprising collagen and chitosan	1608:1663	As described herein, a composite formulation comprising collagen and chitosan improves preservation effects of different types of coatings.
32567143	7	10	theme	edible	1283:1288	arg1	collagen					1290:1297	edible collagen	1283:1297	edible collagen	1283:1297	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	1	11	theme	nitrogen	419:426	arg1	indexes					549:555	deterioration indexes	535:555	deterioration indexes	535:555	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	11	theme	nitrogen	419:426	arg1	scores					511:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	12	theme	soluble	166:172	arg1	PSC					184:186	PSC	184:186	PSC	184:186	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	12	theme	soluble	166:172	arg1	collagen					174:181	Pepsin soluble collagen	159:181	Pepsin soluble collagen (PSC)	159:187	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	3	13	theme	concentration	867:879	arg1	dependence					881:890	no clear PSC concentration dependence	854:890	no clear PSC concentration dependence	854:890	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	2	14	theme	most	663:666	arg1	indexes					682:688	most deterioration indexes	663:688	most deterioration indexes	663:688	Results show that coating by 1% of chitosan solutions containing 0.0%-0.8% of PSC significantly improved most deterioration indexes.
32567143	1	15	theme	porgy	339:343	arg1	quality					367:373	fresh red porgy (Pagrus major) fillet quality	329:373	fresh red porgy (Pagrus major) fillet quality	329:373	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	8	16	theme	maximum	1561:1567	arg1	use					1569:1571	the maximum use	1557:1571	the maximum use of resources	1557:1584	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	7	17	theme	storage	1454:1460	arg1	duration					1462:1469	storage duration	1454:1469	storage duration	1454:1469	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	0	18	from	application	63:73	arg1	skin					50:53	blue shark skin	39:53	blue shark skin	39:53	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	10	19	theme	porgy	1828:1832	arg1	life					1847:1850	the red porgy fillet shelf life	1820:1850	the red porgy fillet shelf life	1820:1850	A more high-quality and effective edible coating formulation was obtained, thereby extending the red porgy fillet shelf life.
32567143	0	20	theme	red	128:130	arg1	meat					153:156	red porgy (Pagrus major) meat	128:156	red porgy (Pagrus major) meat	128:156	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	1	21	from	effects	318:324	arg1	quality					367:373	fresh red porgy (Pagrus major) fillet quality	329:373	fresh red porgy (Pagrus major) fillet quality	329:373	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	22	dep	4°C.	393:396	arg1	measured					523:530	measured	523:530	were measured as deterioration indexes	518:555	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	0	23	theme	major	146:150	arg1	meat					153:156	red porgy (Pagrus major) meat	128:156	red porgy (Pagrus major) meat	128:156	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	3	24	theme	solution	717:724	arg1	%					703:703	1%	702:703	1% of chitosan solution containing 0.8% of PSC	702:747	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	3	24	theme	solution	717:724	arg1	solution					717:724	chitosan solution	708:724	chitosan solution containing 0.8% of PSC	708:747	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	4	25	theme	coating	975:981	arg1	%					954:954	0.8%	951:954	0.8% of PSC	951:961	These results indicate 1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study.
32567143	4	25	theme	coating	975:981	arg1	formulation					983:993	the best coating formulation	966:993	the best coating formulation examined in this study	966:1016	These results indicate 1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study.
32567143	4	25	theme	coating	975:981	arg1	PSC					959:961	PSC	959:961	PSC	959:961	These results indicate 1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study.
32567143	1	26	theme	evaluation	500:509	arg1	indexes					549:555	deterioration indexes	535:555	deterioration indexes	535:555	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	26	theme	evaluation	500:509	arg1	scores					511:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	10	27	theme	shelf	1841:1845	arg1	life					1847:1850	the red porgy fillet shelf life	1820:1850	the red porgy fillet shelf life	1820:1850	A more high-quality and effective edible coating formulation was obtained, thereby extending the red porgy fillet shelf life.
32567143	5	28	theme	Aquatic	1043:1049	arg1	products					1051:1058	Aquatic products	1043:1058	PRACTICAL APPLICATIONS: Aquatic products	1019:1058	PRACTICAL APPLICATIONS: Aquatic products have high contents of water and protein.
32567143	6	29	theme	microorganisms	1248:1261	arg1	role					1216:1219	the role	1212:1219	the role of spoilage and pathogenic microorganisms during storage	1212:1276	Their qualities are likely to decline because of endogenous chemical and enzyme reactions, and also because of the role of spoilage and pathogenic microorganisms during storage.
32567143	2	30	theme	solutions	602:610	arg1	%					588:588	1%	587:588	1% of chitosan solutions containing 0.0%-0.8% of PSC	587:638	Results show that coating by 1% of chitosan solutions containing 0.0%-0.8% of PSC significantly improved most deterioration indexes.
32567143	2	30	theme	solutions	602:610	arg1	solutions					602:610	chitosan solutions	593:610	chitosan solutions containing 0.0%-0.8% of PSC	593:638	Results show that coating by 1% of chitosan solutions containing 0.0%-0.8% of PSC significantly improved most deterioration indexes.
32567143	0	31	from	Characterization	0:15	arg1	skin					50:53	blue shark skin	39:53	blue shark skin	39:53	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	0	32	theme	chitosan-	79:87	arg1	coating					108:114	chitosan- collagen composite coating	79:114	chitosan- collagen composite coating	79:114	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	1	33	theme	pH	464:465	arg1	indexes					549:555	deterioration indexes	535:555	deterioration indexes	535:555	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	33	theme	pH	464:465	arg1	scores					511:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	0	34	theme	composite	98:106	arg1	coating					108:114	chitosan- collagen composite coating	79:114	chitosan- collagen composite coating	79:114	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	1	35	theme	fresh	329:333	arg1	quality					367:373	fresh red porgy (Pagrus major) fillet quality	329:373	fresh red porgy (Pagrus major) fillet quality	329:373	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	0	36	theme	blue	39:42	arg1	skin					50:53	blue shark skin	39:53	blue shark skin	39:53	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	3	37	theme	best	761:764	arg1	results					766:772	the best results	757:772	the best results	757:772	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	1	38	theme	K	468:468	arg1	value					470:474	K value	468:474	K value	468:474	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	3	39	theme	drip	787:790	arg1	loss					792:795	drip loss	787:795	drip loss	787:795	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	0	40	theme	fish	20:23	arg1	collagen					25:32	fish collagen	20:32	fish collagen from blue shark skin	20:53	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	1	41	theme	loss	482:485	arg1	indexes					549:555	deterioration indexes	535:555	deterioration indexes	535:555	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	41	theme	loss	482:485	arg1	scores					511:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	7	42	dep	biodegradable	1350:1362	arg1	biocompatible					1365:1377	biocompatible	1365:1377	biocompatible	1365:1377	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	7	42	dep	biodegradable	1350:1362	arg1	effective					1385:1393	effective	1385:1393	effective	1385:1393	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	7	42	dep	biodegradable	1350:1362	arg1	biodegradable					1350:1362	biodegradable	1350:1362	biodegradable	1350:1362	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	7	42	dep	biodegradable	1350:1362	arg1	able					1403:1406	able	1403:1406	able	1403:1406	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	7	42	dep	biodegradable	1350:1362	arg1	coating					1312:1318	The edible collagen and chitosan coating	1279:1318	The edible collagen and chitosan coating suggested by this research	1279:1345	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	3	43	theme	sensory	802:808	arg1	evaluation					810:819	sensory evaluation	802:819	sensory evaluation	802:819	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	0	44	theme	shark	44:48	arg1	skin					50:53	blue shark skin	39:53	blue shark skin	39:53	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	1	45	theme	chitosan-collagen	259:275	arg1	coating					287:293	chitosan-collagen composite coating	259:293	chitosan-collagen composite coating	259:293	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	9	46	theme	preservation	1674:1685	arg1	effects					1687:1693	preservation effects	1674:1693	preservation effects of different types of coatings	1674:1724	As described herein, a composite formulation comprising collagen and chitosan improves preservation effects of different types of coatings.
32567143	1	47	theme	thiobarbituric	437:450	arg1	TBA					458:460	TBA	458:460	TBA	458:460	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	47	theme	thiobarbituric	437:450	arg1	acid					452:455	thiobarbituric acid	437:455	thiobarbituric acid (TBA)	437:461	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	8	48	theme	Pepsin	1472:1477	arg1	collagen					1487:1494	Pepsin soluble collagen	1472:1494	Pepsin soluble collagen (PSC)	1472:1500	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	8	48	theme	Pepsin	1472:1477	arg1	by-product					1535:1544	an aquatic product processing by-product	1505:1544	an aquatic product processing by-product that makes the maximum use of resources	1505:1584	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	8	48	theme	Pepsin	1472:1477	arg1	PSC					1497:1499	PSC	1497:1499	PSC	1497:1499	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	4	49	theme	solution	931:938	arg1	%					917:917	1%	916:917	1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study	916:1016	These results indicate 1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study.
32567143	4	49	theme	solution	931:938	arg1	solution					931:938	chitosan solution	922:938	chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study	922:1016	These results indicate 1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study.
32567143	9	50	theme	types	1708:1712	arg1	effects					1687:1693	preservation effects	1674:1693	preservation effects of different types of coatings	1674:1724	As described herein, a composite formulation comprising collagen and chitosan improves preservation effects of different types of coatings.
32567143	10	51	theme	high-quality	1734:1745	arg1	formulation					1776:1786	A more high-quality and effective edible coating formulation	1727:1786	A more high-quality and effective edible coating formulation	1727:1786	A more high-quality and effective edible coating formulation was obtained, thereby extending the red porgy fillet shelf life.
32567143	1	52	theme	shark	213:217	arg1	skin					237:240	blue shark (Prionace glauca) skin	208:240	blue shark (Prionace glauca) skin	208:240	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	7	53	theme	chitosan	1303:1310	arg1	coating					1312:1318	The edible collagen and chitosan coating	1279:1318	The edible collagen and chitosan coating suggested by this research	1279:1345	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	7	53	theme	chitosan	1303:1310	arg1	effective					1385:1393	effective	1385:1393	effective	1385:1393	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	7	53	theme	chitosan	1303:1310	arg1	biodegradable					1350:1362	biodegradable	1350:1362	biodegradable	1350:1362	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	7	53	theme	chitosan	1303:1310	arg1	able					1403:1406	able	1403:1406	able	1403:1406	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	7	53	theme	chitosan	1303:1310	arg1	biocompatible					1365:1377	biocompatible	1365:1377	biocompatible	1365:1377	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	9	54	theme	coatings	1717:1724	arg1	types					1708:1712	different types	1698:1712	different types of coatings	1698:1724	As described herein, a composite formulation comprising collagen and chitosan improves preservation effects of different types of coatings.
32567143	1	55	theme	Prionace	220:227	arg1	skin					237:240	blue shark (Prionace glauca) skin	208:240	blue shark (Prionace glauca) skin	208:240	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	7	56	theme	collagen	1290:1297	arg1	coating					1312:1318	The edible collagen and chitosan coating	1279:1318	The edible collagen and chitosan coating suggested by this research	1279:1345	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	7	56	theme	collagen	1290:1297	arg1	effective					1385:1393	effective	1385:1393	effective	1385:1393	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	7	56	theme	collagen	1290:1297	arg1	biodegradable					1350:1362	biodegradable	1350:1362	biodegradable	1350:1362	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	7	56	theme	collagen	1290:1297	arg1	able					1403:1406	able	1403:1406	able	1403:1406	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	7	56	theme	collagen	1290:1297	arg1	biocompatible					1365:1377	biocompatible	1365:1377	biocompatible	1365:1377	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	5	57	contain	have	1060:1063	arg1	APPLICATIONS					1029:1040	PRACTICAL APPLICATIONS	1019:1040	PRACTICAL APPLICATIONS: Aquatic products	1019:1058	PRACTICAL APPLICATIONS: Aquatic products have high contents of water and protein.
32567143	5	57	contain	have	1060:1063	arg2	contents					1070:1077	high contents	1065:1077	high contents of water and protein	1065:1098	PRACTICAL APPLICATIONS: Aquatic products have high contents of water and protein.
32567143	2	58	theme	PSC	636:638	arg1	PSC					636:638	PSC	636:638	PSC	636:638	Results show that coating by 1% of chitosan solutions containing 0.0%-0.8% of PSC significantly improved most deterioration indexes.
32567143	2	58	theme	PSC	636:638	arg1	%					631:631	0.0%-0.8%	623:631	0.0%-0.8% of PSC	623:638	Results show that coating by 1% of chitosan solutions containing 0.0%-0.8% of PSC significantly improved most deterioration indexes.
32567143	10	59	theme	coating	1768:1774	arg1	formulation					1776:1786	A more high-quality and effective edible coating formulation	1727:1786	A more high-quality and effective edible coating formulation	1727:1786	A more high-quality and effective edible coating formulation was obtained, thereby extending the red porgy fillet shelf life.
32567143	1	60	theme	Total	398:402	arg1	indexes					549:555	deterioration indexes	535:555	deterioration indexes	535:555	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	60	theme	Total	398:402	arg1	scores					511:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	8	61	theme	aquatic	1508:1514	arg1	collagen					1487:1494	Pepsin soluble collagen	1472:1494	Pepsin soluble collagen (PSC)	1472:1500	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	8	61	theme	aquatic	1508:1514	arg1	by-product					1535:1544	an aquatic product processing by-product	1505:1544	an aquatic product processing by-product that makes the maximum use of resources	1505:1584	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	1	62	theme	deterioration	535:547	arg1	indexes					549:555	deterioration indexes	535:555	deterioration indexes	535:555	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	62	theme	deterioration	535:547	arg1	scores					511:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	63	theme	basic	413:417	arg1	TVB-N					429:433	TVB-N	429:433	TVB-N	429:433	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	63	theme	basic	413:417	arg1	nitrogen					419:426	basic nitrogen	413:426	basic nitrogen (TVB-N)	413:434	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	8	64	theme	processing	1524:1533	arg1	collagen					1487:1494	Pepsin soluble collagen	1472:1494	Pepsin soluble collagen (PSC)	1472:1500	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	8	64	theme	processing	1524:1533	arg1	by-product					1535:1544	an aquatic product processing by-product	1505:1544	an aquatic product processing by-product that makes the maximum use of resources	1505:1584	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	1	65	theme	Pepsin	159:164	arg1	PSC					184:186	PSC	184:186	PSC	184:186	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	65	theme	Pepsin	159:164	arg1	collagen					174:181	Pepsin soluble collagen	159:181	Pepsin soluble collagen (PSC)	159:187	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	3	66	theme	PSC	863:865	arg1	dependence					881:890	no clear PSC concentration dependence	854:890	no clear PSC concentration dependence	854:890	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	2	67	theme	deterioration	668:680	arg1	indexes					682:688	most deterioration indexes	663:688	most deterioration indexes	663:688	Results show that coating by 1% of chitosan solutions containing 0.0%-0.8% of PSC significantly improved most deterioration indexes.
32567143	6	68	theme	enzyme	1174:1179	arg1	reactions					1181:1189	endogenous chemical and enzyme reactions	1150:1189	reactions	1181:1189	Their qualities are likely to decline because of endogenous chemical and enzyme reactions, and also because of the role of spoilage and pathogenic microorganisms during storage.
32567143	0	69	theme	porgy	132:136	arg1	meat					153:156	red porgy (Pagrus major) meat	128:156	red porgy (Pagrus major) meat	128:156	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	7	70	theme	food	1437:1440	arg1	quality					1442:1448	food quality	1437:1448	food quality	1437:1448	The edible collagen and chitosan coating suggested by this research is biodegradable, biocompatible, cost effective, and is able to meet the requirements for food quality and storage duration.
32567143	2	71	theme	chitosan	593:600	arg1	solutions					602:610	chitosan solutions	593:610	chitosan solutions containing 0.0%-0.8% of PSC	593:638	Results show that coating by 1% of chitosan solutions containing 0.0%-0.8% of PSC significantly improved most deterioration indexes.
32567143	10	72	theme	red	1824:1826	arg1	life					1847:1850	the red porgy fillet shelf life	1820:1850	the red porgy fillet shelf life	1820:1850	A more high-quality and effective edible coating formulation was obtained, thereby extending the red porgy fillet shelf life.
32567143	0	73	theme	Pagrus	139:144	arg1	meat					153:156	red porgy (Pagrus major) meat	128:156	red porgy (Pagrus major) meat	128:156	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	1	74	theme	major	353:357	arg1	Pagrus					346:351	Pagrus major	346:357	Pagrus major	346:357	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	74	theme	major	353:357	arg1	porgy					339:343	red porgy	335:343	fresh red porgy (Pagrus major) fillet quality	329:373	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	75	theme	fillet	360:365	arg1	quality					367:373	fresh red porgy (Pagrus major) fillet quality	329:373	fresh red porgy (Pagrus major) fillet quality	329:373	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	8	76	theme	resources	1576:1584	arg1	use					1569:1571	the maximum use	1557:1571	the maximum use of resources	1557:1584	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	5	77	dep	APPLICATIONS	1029:1040	arg1	products					1051:1058	Aquatic products	1043:1058	PRACTICAL APPLICATIONS: Aquatic products	1019:1058	PRACTICAL APPLICATIONS: Aquatic products have high contents of water and protein.
32567143	2	78	theme	%	626:626	arg1	PSC					636:638	PSC	636:638	PSC	636:638	Results show that coating by 1% of chitosan solutions containing 0.0%-0.8% of PSC significantly improved most deterioration indexes.
32567143	2	78	theme	%	626:626	arg1	%					631:631	0.0%-0.8%	623:631	0.0%-0.8% of PSC	623:638	Results show that coating by 1% of chitosan solutions containing 0.0%-0.8% of PSC significantly improved most deterioration indexes.
32567143	1	79	theme	sensory	492:498	arg1	evaluation					500:509	sensory evaluation	492:509	sensory evaluation	492:509	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	5	80	theme	water	1082:1086	arg1	contents					1070:1077	high contents	1065:1077	high contents of water and protein	1065:1098	PRACTICAL APPLICATIONS: Aquatic products have high contents of water and protein.
32567143	10	81	theme	fillet	1834:1839	arg1	life					1847:1850	the red porgy fillet shelf life	1820:1850	the red porgy fillet shelf life	1820:1850	A more high-quality and effective edible coating formulation was obtained, thereby extending the red porgy fillet shelf life.
32567143	5	82	theme	protein	1092:1098	arg1	contents					1070:1077	high contents	1065:1077	high contents of water and protein	1065:1098	PRACTICAL APPLICATIONS: Aquatic products have high contents of water and protein.
32567143	3	83	theme	chitosan	708:715	arg1	solution					717:724	chitosan solution	708:724	chitosan solution containing 0.8% of PSC	708:747	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	0	84	theme	collagen	89:96	arg1	coating					108:114	chitosan- collagen composite coating	79:114	chitosan- collagen composite coating	79:114	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	1	85	theme	coating	310:316	arg1	effects					318:324	coating effects	310:324	coating effects on fresh red porgy (Pagrus major) fillet quality	310:373	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	3	86	theme	PSC	745:747	arg1	PSC					745:747	PSC	745:747	PSC	745:747	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	3	86	theme	PSC	745:747	arg1	%					740:740	0.8%	737:740	0.8% of PSC	737:747	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	0	87	from	skin	50:53	arg1	application					63:73	its application	59:73	its application for chitosan- collagen composite coating	59:114	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	0	87	from	skin	50:53	arg1	Characterization					0:15	Characterization	0:15	Characterization of fish collagen from blue shark skin	0:53	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	0	87	from	skin	50:53	arg1	collagen					25:32	fish collagen	20:32	fish collagen from blue shark skin	20:53	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	3	88	theme	K	778:778	arg1	value					780:784	K value	778:784	K value	778:784	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	1	89	theme	red	335:337	arg1	Pagrus					346:351	Pagrus major	346:357	Pagrus major	346:357	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	89	theme	red	335:337	arg1	porgy					339:343	red porgy	335:343	fresh red porgy (Pagrus major) fillet quality	329:373	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	6	90	theme	chemical	1161:1168	arg1	decline					1131:1137	decline	1131:1137	decline because of endogenous chemical and enzyme reactions	1131:1189	Their qualities are likely to decline because of endogenous chemical and enzyme reactions, and also because of the role of spoilage and pathogenic microorganisms during storage.
32567143	1	91	theme	value	470:474	arg1	indexes					549:555	deterioration indexes	535:555	deterioration indexes	535:555	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	91	theme	value	470:474	arg1	scores					511:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	0	92	theme	collagen	25:32	arg1	application					63:73	its application	59:73	its application for chitosan- collagen composite coating	59:114	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	0	92	theme	collagen	25:32	arg1	Characterization					0:15	Characterization	0:15	Characterization of fish collagen from blue shark skin	0:53	Characterization of fish collagen from blue shark skin and its application for chitosan- collagen composite coating to preserve red porgy (Pagrus major) meat.
32567143	1	93	theme	drip	477:480	arg1	loss					482:485	drip loss	477:485	drip loss	477:485	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	6	94	theme	pathogenic	1237:1246	arg1	microorganisms					1248:1261	pathogenic microorganisms	1237:1261	pathogenic microorganisms	1237:1261	Their qualities are likely to decline because of endogenous chemical and enzyme reactions, and also because of the role of spoilage and pathogenic microorganisms during storage.
32567143	5	95	theme	PRACTICAL	1019:1027	arg1	APPLICATIONS					1029:1040	PRACTICAL APPLICATIONS	1019:1040	PRACTICAL APPLICATIONS: Aquatic products	1019:1058	PRACTICAL APPLICATIONS: Aquatic products have high contents of water and protein.
32567143	4	96	contain	containing	940:949	arg2	%					954:954	0.8%	951:954	0.8% of PSC	951:961	These results indicate 1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study.
32567143	4	96	contain	containing	940:949	arg2	PSC					959:961	PSC	959:961	PSC	959:961	These results indicate 1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study.
32567143	4	96	contain	containing	940:949	arg2	formulation					983:993	the best coating formulation	966:993	the best coating formulation examined in this study	966:1016	These results indicate 1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study.
32567143	4	96	contain	containing	940:949	arg1	solution					931:938	chitosan solution	922:938	chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study	922:1016	These results indicate 1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study.
32567143	9	97	theme	different	1698:1706	arg1	types					1708:1712	different types	1698:1712	different types of coatings	1698:1724	As described herein, a composite formulation comprising collagen and chitosan improves preservation effects of different types of coatings.
32567143	6	98	theme	reactions	1181:1189	arg1	decline					1131:1137	decline	1131:1137	decline because of endogenous chemical and enzyme reactions	1131:1189	Their qualities are likely to decline because of endogenous chemical and enzyme reactions, and also because of the role of spoilage and pathogenic microorganisms during storage.
32567143	6	99	theme	spoilage	1224:1231	arg1	role					1216:1219	the role	1212:1219	the role of spoilage and pathogenic microorganisms during storage	1212:1276	Their qualities are likely to decline because of endogenous chemical and enzyme reactions, and also because of the role of spoilage and pathogenic microorganisms during storage.
32567143	8	100	theme	soluble	1479:1485	arg1	collagen					1487:1494	Pepsin soluble collagen	1472:1494	Pepsin soluble collagen (PSC)	1472:1500	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	8	100	theme	soluble	1479:1485	arg1	by-product					1535:1544	an aquatic product processing by-product	1505:1544	an aquatic product processing by-product that makes the maximum use of resources	1505:1584	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	8	100	theme	soluble	1479:1485	arg1	PSC					1497:1499	PSC	1497:1499	PSC	1497:1499	Pepsin soluble collagen (PSC) is an aquatic product processing by-product that makes the maximum use of resources.
32567143	1	101	theme	composite	277:285	arg1	coating					287:293	chitosan-collagen composite coating	259:293	chitosan-collagen composite coating	259:293	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	102	theme	acid	452:455	arg1	indexes					549:555	deterioration indexes	535:555	deterioration indexes	535:555	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	1	102	theme	acid	452:455	arg1	scores					511:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores	398:516	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	5	103	theme	high	1065:1068	arg1	contents					1070:1077	high contents	1065:1077	high contents of water and protein	1065:1098	PRACTICAL APPLICATIONS: Aquatic products have high contents of water and protein.
32567143	3	104	theme	other	835:839	arg1	indexes					841:847	the other indexes	831:847	the other indexes	831:847	Coating by 1% of chitosan solution containing 0.8% of PSC yielded the best results for K value, drip loss, and sensory evaluation, although the other indexes show no clear PSC concentration dependence.
32567143	1	105	from	4°C.	393:396	arg1	storage					382:388	storage	382:388	storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes	382:555	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
32567143	4	106	theme	chitosan	922:929	arg1	solution					931:938	chitosan solution	922:938	chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study	922:1016	These results indicate 1% of chitosan solution containing 0.8% of PSC as the best coating formulation examined in this study.
32567143	1	107	theme	blue	208:211	arg1	skin					237:240	blue shark (Prionace glauca) skin	208:240	blue shark (Prionace glauca) skin	208:240	Pepsin soluble collagen (PSC) was extracted from blue shark (Prionace glauca) skin and was used for chitosan-collagen composite coating to investigate coating effects on fresh red porgy (Pagrus major) fillet quality during storage at 4°C. Total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA), pH, K value, drip loss, and sensory evaluation scores were measured as deterioration indexes.
34704177	3	0	theme	acid-linked	376:386	arg1	nanoparticles					397:409	glycyrrhetinic acid-linked chitosan nanoparticles	361:409	glycyrrhetinic acid-linked chitosan nanoparticles loaded with Cliv-92	361:429	Therefore, glycyrrhetinic acid-linked chitosan nanoparticles loaded with Cliv-92 were prepared for active targeting to the liver.
34704177	6	1	theme	30.93 mV	919:926	arg1	size					848:851	a mean particle size	832:851	a mean particle size of 185.17 nm	832:864	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	1	theme	30.93 mV	919:926	arg1	loading					940:946	a drug loading	933:946	a drug loading of 16.30%	933:956	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	1	theme	30.93 mV	919:926	arg1	index					884:888	a polydispersity index	867:888	a polydispersity index of 0.41	867:896	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	1	theme	30.93 mV	919:926	arg1	potential					906:914	a zeta potential	899:914	a zeta potential of 30.93 mV	899:926	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	7	2	theme	%	1028:1028	arg1	release					1001:1007	sustained release	991:1007	sustained release of approximately 63% of loaded Cliv-92	991:1046	The prepared formulation showed sustained release of approximately 63% of loaded Cliv-92 over 72 h.
34704177	11	3	theme	Cliv-92	1560:1566	arg1	nanoparticles					1568:1580	fabricated Cliv-92 nanoparticles	1549:1580	fabricated Cliv-92 nanoparticles	1549:1580	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	3	4	theme	chitosan	388:395	arg1	nanoparticles					397:409	glycyrrhetinic acid-linked chitosan nanoparticles	361:409	glycyrrhetinic acid-linked chitosan nanoparticles loaded with Cliv-92	361:429	Therefore, glycyrrhetinic acid-linked chitosan nanoparticles loaded with Cliv-92 were prepared for active targeting to the liver.
34704177	4	5	theme	agitation	585:593	arg1	use					554:556	the use	550:556	the use of toxic solvents/rigorous agitation	550:593	The nanoparticles were prepared by the ionic gelation method to avoid the use of toxic solvents/rigorous agitation.
34704177	6	6	theme	particle	839:846	arg1	size					848:851	a mean particle size	832:851	a mean particle size of 185.17 nm	832:864	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	1	7	theme	similar	195:201	arg1	coumarinolignoids					203:219	three structurally similar coumarinolignoids	176:219	three structurally similar coumarinolignoids	176:219	Cliv-92 is a mixture of three structurally similar coumarinolignoids and a proven hepatoprotective agent.
34704177	10	8	theme	In	1215:1216	arg1	study					1231:1235	In vivo imaging study	1215:1235	In vivo imaging study	1215:1235	In vivo imaging study showed that optimized nanoparticles were preferentially accumulated in the liver and successfully targeting the liver.
34704177	11	9	theme	relative	1446:1453	arg1	properties					1429:1438	the improved pharmacokinetic properties	1400:1438	the improved pharmacokinetic properties (≈12% relative bioavailability)	1400:1470	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	11	9	theme	relative	1446:1453	arg1	bioavailability					1455:1469	≈12% relative bioavailability	1441:1469	≈12% relative bioavailability	1441:1469	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	4	10	theme	solvents/rigorous	567:583	arg1	agitation					585:593	toxic solvents/rigorous agitation	561:593	toxic solvents/rigorous agitation	561:593	The nanoparticles were prepared by the ionic gelation method to avoid the use of toxic solvents/rigorous agitation.
34704177	5	11	theme	independent	674:684	arg1	concentration					748:760	crosslinker concentration	736:760	crosslinker concentration (0.5%)	736:767	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	11	theme	independent	674:684	arg1	variables					686:694	independent variables	674:694	independent variables	674:694	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	11	theme	independent	674:684	arg1	speed					783:787	stirring speed	774:787	stirring speed (750 rpm)	774:797	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	11	theme	independent	674:684	arg1	ratio					718:722	polymer: drug ratio	704:722	polymer: drug ratio (3:1, w/w)	704:733	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	11	12	dep	in	1507:1508	arg1	vivo					1510:1513	vivo	1510:1513	vivo	1510:1513	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	7	13	theme	prepared	963:970	arg1	formulation					972:982	The prepared formulation	959:982	The prepared formulation	959:982	The prepared formulation showed sustained release of approximately 63% of loaded Cliv-92 over 72 h.
34704177	0	14	theme	In	132:133	arg1	Evaluation					140:149	In Vivo Evaluation	132:149	In Vivo Evaluation	132:149	Cliv-92-Loaded Glycyrrhetinic Acid-Modified Chitosan Nanoparticles for Enhanced Hepatoprotection-Preparation, Characterization, and In Vivo Evaluation.
34704177	6	15	theme	zeta	901:904	arg1	potential					906:914	a zeta potential	899:914	a zeta potential of 30.93 mV	899:926	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	11	16	theme	nanoparticles	1568:1580	arg1	properties					1429:1438	the improved pharmacokinetic properties	1400:1438	the improved pharmacokinetic properties (≈12% relative bioavailability)	1400:1470	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	11	16	theme	nanoparticles	1568:1580	arg1	profile					1485:1491	efficacy profile	1476:1491	efficacy profile	1476:1491	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	11	16	theme	nanoparticles	1568:1580	arg1	bioavailability					1455:1469	≈12% relative bioavailability	1441:1469	≈12% relative bioavailability	1441:1469	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	2	17	theme	further	337:343	arg1	use					345:347	its further use	333:347	its further use	333:347	Low aqueous solubility and poor bioavailability are notable hindrances for its further use.
34704177	11	18	theme	efficacy	1476:1483	arg1	profile					1485:1491	efficacy profile	1476:1491	efficacy profile	1476:1491	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	11	19	theme	≈12	1441:1443	arg1	%					1444:1444	%	1444:1444	%	1444:1444	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	9	20	theme	parenteral	1194:1203	arg1	delivery					1205:1212	parenteral delivery	1194:1212	parenteral delivery	1194:1212	The formulation was found to be biocompatible for parenteral delivery.
34704177	1	21	theme	coumarinolignoids	203:219	arg1	agent					251:255	a proven hepatoprotective agent	225:255	a proven hepatoprotective agent	225:255	Cliv-92 is a mixture of three structurally similar coumarinolignoids and a proven hepatoprotective agent.
34704177	1	21	theme	coumarinolignoids	203:219	arg1	Cliv-92					152:158	Cliv-92	152:158	Cliv-92	152:158	Cliv-92 is a mixture of three structurally similar coumarinolignoids and a proven hepatoprotective agent.
34704177	1	21	theme	coumarinolignoids	203:219	arg1	mixture					165:171	a mixture	163:171	a mixture of three structurally similar coumarinolignoids	163:219	Cliv-92 is a mixture of three structurally similar coumarinolignoids and a proven hepatoprotective agent.
34704177	5	22	theme	stirring	774:781	arg1	variables					686:694	independent variables	674:694	independent variables	674:694	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	22	theme	stirring	774:781	arg1	750 rpm					790:796	750 rpm	790:796	750 rpm	790:796	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	22	theme	stirring	774:781	arg1	speed					783:787	stirring speed	774:787	stirring speed (750 rpm)	774:797	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	23	theme	polymer	704:710	arg1	variables					686:694	independent variables	674:694	independent variables	674:694	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	23	theme	polymer	704:710	arg1	ratio					718:722	polymer: drug ratio	704:722	polymer: drug ratio (3:1, w/w)	704:733	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	0	24	dep	In	132:133	arg1	Vivo					135:138	Vivo	135:138	Vivo	135:138	Cliv-92-Loaded Glycyrrhetinic Acid-Modified Chitosan Nanoparticles for Enhanced Hepatoprotection-Preparation, Characterization, and In Vivo Evaluation.
34704177	0	25	theme	Glycyrrhetinic	15:28	arg1	Chitosan					44:51	Cliv-92-Loaded Glycyrrhetinic Acid-Modified Chitosan	0:51	Cliv-92-Loaded Glycyrrhetinic Acid-Modified Chitosan	0:51	Cliv-92-Loaded Glycyrrhetinic Acid-Modified Chitosan Nanoparticles for Enhanced Hepatoprotection-Preparation, Characterization, and In Vivo Evaluation.
34704177	6	26	theme	0.41	893:896	arg1	size					848:851	a mean particle size	832:851	a mean particle size of 185.17 nm	832:864	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	26	theme	0.41	893:896	arg1	loading					940:946	a drug loading	933:946	a drug loading of 16.30%	933:956	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	26	theme	0.41	893:896	arg1	index					884:888	a polydispersity index	867:888	a polydispersity index of 0.41	867:896	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	26	theme	0.41	893:896	arg1	potential					906:914	a zeta potential	899:914	a zeta potential of 30.93 mV	899:926	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	5	27	theme	central	644:650	arg1	design					662:667	a central composite design	642:667	a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm)	642:797	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	3	28	link	acid-linked	376:386	arg1	nanoparticles					397:409	glycyrrhetinic acid-linked chitosan nanoparticles	361:409	glycyrrhetinic acid-linked chitosan nanoparticles loaded with Cliv-92	361:429	Therefore, glycyrrhetinic acid-linked chitosan nanoparticles loaded with Cliv-92 were prepared for active targeting to the liver.
34704177	7	29	theme	loaded	1033:1038	arg1	Cliv-92					1040:1046	loaded Cliv-92	1033:1046	loaded Cliv-92	1033:1046	The prepared formulation showed sustained release of approximately 63% of loaded Cliv-92 over 72 h.
34704177	0	30	theme	Cliv-92-Loaded	0:13	arg1	Chitosan					44:51	Cliv-92-Loaded Glycyrrhetinic Acid-Modified Chitosan	0:51	Cliv-92-Loaded Glycyrrhetinic Acid-Modified Chitosan	0:51	Cliv-92-Loaded Glycyrrhetinic Acid-Modified Chitosan Nanoparticles for Enhanced Hepatoprotection-Preparation, Characterization, and In Vivo Evaluation.
34704177	5	31	theme	drug	713:716	arg1	variables					686:694	independent variables	674:694	independent variables	674:694	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	31	theme	drug	713:716	arg1	ratio					718:722	polymer: drug ratio	704:722	polymer: drug ratio (3:1, w/w)	704:733	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	32	theme	composite	652:660	arg1	design					662:667	a central composite design	642:667	a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm)	642:797	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	1	33	theme	proven	227:232	arg1	agent					251:255	a proven hepatoprotective agent	225:255	a proven hepatoprotective agent	225:255	Cliv-92 is a mixture of three structurally similar coumarinolignoids and a proven hepatoprotective agent.
34704177	5	34	dep	ratio	718:722	arg1	w/w					730:732	w/w	730:732	w/w	730:732	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	34	dep	ratio	718:722	arg1	3:1					725:727	3:1	725:727	3:1	725:727	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	35	with	design	662:667	arg1	concentration					748:760	crosslinker concentration	736:760	crosslinker concentration (0.5%)	736:767	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	35	with	design	662:667	arg1	variables					686:694	independent variables	674:694	independent variables	674:694	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	35	with	design	662:667	arg1	speed					783:787	stirring speed	774:787	stirring speed (750 rpm)	774:797	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	35	with	design	662:667	arg1	ratio					718:722	polymer: drug ratio	704:722	polymer: drug ratio (3:1, w/w)	704:733	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	11	36	theme	in	1507:1508	arg1	studies					1537:1543	in vivo and histopathological studies	1507:1543	in vivo and histopathological studies	1507:1543	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	1	37	theme	hepatoprotective	234:249	arg1	agent					251:255	a proven hepatoprotective agent	225:255	a proven hepatoprotective agent	225:255	Cliv-92 is a mixture of three structurally similar coumarinolignoids and a proven hepatoprotective agent.
34704177	3	38	theme	active	449:454	arg1	targeting					456:464	active targeting	449:464	active targeting to the liver	449:477	Therefore, glycyrrhetinic acid-linked chitosan nanoparticles loaded with Cliv-92 were prepared for active targeting to the liver.
34704177	4	39	theme	ionic	519:523	arg1	method					534:539	the ionic gelation method	515:539	the ionic gelation method to avoid the use of toxic solvents/rigorous agitation	515:593	The nanoparticles were prepared by the ionic gelation method to avoid the use of toxic solvents/rigorous agitation.
34704177	6	40	theme	%	956:956	arg1	size					848:851	a mean particle size	832:851	a mean particle size of 185.17 nm	832:864	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	40	theme	%	956:956	arg1	loading					940:946	a drug loading	933:946	a drug loading of 16.30%	933:956	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	40	theme	%	956:956	arg1	index					884:888	a polydispersity index	867:888	a polydispersity index of 0.41	867:896	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	40	theme	%	956:956	arg1	potential					906:914	a zeta potential	899:914	a zeta potential of 30.93 mV	899:926	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	7	41	theme	Cliv-92	1040:1046	arg1	release					1001:1007	sustained release	991:1007	sustained release of approximately 63% of loaded Cliv-92	991:1046	The prepared formulation showed sustained release of approximately 63% of loaded Cliv-92 over 72 h.
34704177	2	42	theme	poor	285:288	arg1	solubility					270:279	Low aqueous solubility	258:279	Low aqueous solubility	258:279	Low aqueous solubility and poor bioavailability are notable hindrances for its further use.
34704177	2	42	theme	poor	285:288	arg1	bioavailability					290:304	poor bioavailability	285:304	poor bioavailability	285:304	Low aqueous solubility and poor bioavailability are notable hindrances for its further use.
34704177	2	42	theme	poor	285:288	arg1	hindrances					318:327	notable hindrances	310:327	notable hindrances for its further use	310:347	Low aqueous solubility and poor bioavailability are notable hindrances for its further use.
34704177	11	43	theme	improved	1404:1411	arg1	properties					1429:1438	the improved pharmacokinetic properties	1400:1438	the improved pharmacokinetic properties (≈12% relative bioavailability)	1400:1470	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	11	43	theme	improved	1404:1411	arg1	bioavailability					1455:1469	≈12% relative bioavailability	1441:1469	≈12% relative bioavailability	1441:1469	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	6	44	theme	polydispersity	869:882	arg1	index					884:888	a polydispersity index	867:888	a polydispersity index of 0.41	867:896	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	5	45	theme	preparation	610:620	arg1	method					600:605	The method	596:605	The method of preparation	596:620	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	11	46	theme	%	1444:1444	arg1	properties					1429:1438	the improved pharmacokinetic properties	1400:1438	the improved pharmacokinetic properties (≈12% relative bioavailability)	1400:1470	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	11	46	theme	%	1444:1444	arg1	bioavailability					1455:1469	≈12% relative bioavailability	1441:1469	≈12% relative bioavailability	1441:1469	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	6	47	theme	drug	935:938	arg1	loading					940:946	a drug loading	933:946	a drug loading of 16.30%	933:956	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	8	48	theme	long-term	1099:1107	arg1	storage					1109:1115	long-term storage	1099:1115	long-term storage	1099:1115	The nanoparticles were freeze-dried for long-term storage and further characterized.
34704177	4	49	theme	gelation	525:532	arg1	method					534:539	the ionic gelation method	515:539	the ionic gelation method to avoid the use of toxic solvents/rigorous agitation	515:593	The nanoparticles were prepared by the ionic gelation method to avoid the use of toxic solvents/rigorous agitation.
34704177	0	50	theme	Enhanced	71:78	arg1	Hepatoprotection-Preparation					80:107	Hepatoprotection-Preparation	80:107	Hepatoprotection-Preparation	80:107	Cliv-92-Loaded Glycyrrhetinic Acid-Modified Chitosan Nanoparticles for Enhanced Hepatoprotection-Preparation, Characterization, and In Vivo Evaluation.
34704177	3	51	theme	glycyrrhetinic	361:374	arg1	nanoparticles					397:409	glycyrrhetinic acid-linked chitosan nanoparticles	361:409	glycyrrhetinic acid-linked chitosan nanoparticles loaded with Cliv-92	361:429	Therefore, glycyrrhetinic acid-linked chitosan nanoparticles loaded with Cliv-92 were prepared for active targeting to the liver.
34704177	2	52	theme	Low	258:260	arg1	solubility					270:279	Low aqueous solubility	258:279	Low aqueous solubility	258:279	Low aqueous solubility and poor bioavailability are notable hindrances for its further use.
34704177	2	52	theme	Low	258:260	arg1	bioavailability					290:304	poor bioavailability	285:304	poor bioavailability	285:304	Low aqueous solubility and poor bioavailability are notable hindrances for its further use.
34704177	2	52	theme	Low	258:260	arg1	hindrances					318:327	notable hindrances	310:327	notable hindrances for its further use	310:347	Low aqueous solubility and poor bioavailability are notable hindrances for its further use.
34704177	2	53	theme	aqueous	262:268	arg1	solubility					270:279	Low aqueous solubility	258:279	Low aqueous solubility	258:279	Low aqueous solubility and poor bioavailability are notable hindrances for its further use.
34704177	2	53	theme	aqueous	262:268	arg1	bioavailability					290:304	poor bioavailability	285:304	poor bioavailability	285:304	Low aqueous solubility and poor bioavailability are notable hindrances for its further use.
34704177	2	53	theme	aqueous	262:268	arg1	hindrances					318:327	notable hindrances	310:327	notable hindrances for its further use	310:347	Low aqueous solubility and poor bioavailability are notable hindrances for its further use.
34704177	7	54	theme	sustained	991:999	arg1	release					1001:1007	sustained release	991:1007	sustained release of approximately 63% of loaded Cliv-92	991:1046	The prepared formulation showed sustained release of approximately 63% of loaded Cliv-92 over 72 h.
34704177	11	55	theme	histopathological	1519:1535	arg1	studies					1537:1543	in vivo and histopathological studies	1507:1543	in vivo and histopathological studies	1507:1543	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	6	56	theme	185.17 nm	856:864	arg1	size					848:851	a mean particle size	832:851	a mean particle size of 185.17 nm	832:864	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	56	theme	185.17 nm	856:864	arg1	loading					940:946	a drug loading	933:946	a drug loading of 16.30%	933:956	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	56	theme	185.17 nm	856:864	arg1	index					884:888	a polydispersity index	867:888	a polydispersity index of 0.41	867:896	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	56	theme	185.17 nm	856:864	arg1	potential					906:914	a zeta potential	899:914	a zeta potential of 30.93 mV	899:926	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	57	theme	mean	834:837	arg1	size					848:851	a mean particle size	832:851	a mean particle size of 185.17 nm	832:864	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	11	58	theme	pharmacokinetic	1413:1427	arg1	properties					1429:1438	the improved pharmacokinetic properties	1400:1438	the improved pharmacokinetic properties (≈12% relative bioavailability)	1400:1470	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	11	58	theme	pharmacokinetic	1413:1427	arg1	bioavailability					1455:1469	≈12% relative bioavailability	1441:1469	≈12% relative bioavailability	1441:1469	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	5	59	theme	crosslinker	736:746	arg1	variables					686:694	independent variables	674:694	independent variables	674:694	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	59	theme	crosslinker	736:746	arg1	concentration					748:760	crosslinker concentration	736:760	crosslinker concentration (0.5%)	736:767	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	5	59	theme	crosslinker	736:746	arg1	%					766:766	0.5%	763:766	0.5%	763:766	The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm).
34704177	11	60	dep	properties	1429:1438	arg1	evidenced					1494:1502	evidenced	1494:1502	evidenced by in vivo and histopathological studies	1494:1543	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	2	61	theme	notable	310:316	arg1	solubility					270:279	Low aqueous solubility	258:279	Low aqueous solubility	258:279	Low aqueous solubility and poor bioavailability are notable hindrances for its further use.
34704177	2	61	theme	notable	310:316	arg1	bioavailability					290:304	poor bioavailability	285:304	poor bioavailability	285:304	Low aqueous solubility and poor bioavailability are notable hindrances for its further use.
34704177	2	61	theme	notable	310:316	arg1	hindrances					318:327	notable hindrances	310:327	notable hindrances for its further use	310:347	Low aqueous solubility and poor bioavailability are notable hindrances for its further use.
34704177	11	62	theme	present	1360:1366	arg1	study					1368:1372	The present study	1356:1372	The present study	1356:1372	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
34704177	6	63	contain	had	828:830	arg2	size					848:851	a mean particle size	832:851	a mean particle size of 185.17 nm	832:864	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	63	contain	had	828:830	arg2	index					884:888	a polydispersity index	867:888	a polydispersity index of 0.41	867:896	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	63	contain	had	828:830	arg1	nanoparticles					814:826	The optimized nanoparticles	800:826	The optimized nanoparticles	800:826	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	63	contain	had	828:830	arg2	loading					940:946	a drug loading	933:946	a drug loading of 16.30%	933:956	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	6	63	contain	had	828:830	arg2	potential					906:914	a zeta potential	899:914	a zeta potential of 30.93 mV	899:926	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	10	64	theme	optimized	1249:1257	arg1	nanoparticles					1259:1271	optimized nanoparticles	1249:1271	optimized nanoparticles	1249:1271	In vivo imaging study showed that optimized nanoparticles were preferentially accumulated in the liver and successfully targeting the liver.
34704177	10	65	dep	In	1215:1216	arg1	vivo					1218:1221	vivo	1218:1221	vivo	1218:1221	In vivo imaging study showed that optimized nanoparticles were preferentially accumulated in the liver and successfully targeting the liver.
34704177	10	66	theme	imaging	1223:1229	arg1	study					1231:1235	In vivo imaging study	1215:1235	In vivo imaging study	1215:1235	In vivo imaging study showed that optimized nanoparticles were preferentially accumulated in the liver and successfully targeting the liver.
34704177	6	67	theme	optimized	804:812	arg1	nanoparticles					814:826	The optimized nanoparticles	800:826	The optimized nanoparticles	800:826	The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%.
34704177	4	68	theme	toxic	561:565	arg1	agitation					585:593	toxic solvents/rigorous agitation	561:593	toxic solvents/rigorous agitation	561:593	The nanoparticles were prepared by the ionic gelation method to avoid the use of toxic solvents/rigorous agitation.
34704177	0	69	theme	Acid-Modified	30:42	arg1	Chitosan					44:51	Cliv-92-Loaded Glycyrrhetinic Acid-Modified Chitosan	0:51	Cliv-92-Loaded Glycyrrhetinic Acid-Modified Chitosan	0:51	Cliv-92-Loaded Glycyrrhetinic Acid-Modified Chitosan Nanoparticles for Enhanced Hepatoprotection-Preparation, Characterization, and In Vivo Evaluation.
34704177	11	70	theme	fabricated	1549:1558	arg1	nanoparticles					1568:1580	fabricated Cliv-92 nanoparticles	1549:1580	fabricated Cliv-92 nanoparticles	1549:1580	The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
32057879	0	0	theme	Adsorption/desorption	104:124	arg1	studies					150:156	Adsorption/desorption, kinetics and recycling studies	104:156	Adsorption/desorption, kinetics and recycling studies	104:156	Efficient removal of dyes using carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite: Adsorption/desorption, kinetics and recycling studies.
32057879	2	1	theme	Direct	368:373	arg1	MRH					465:467	MRH	465:467	MRH	465:467	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	1	theme	Direct	368:373	arg1	DB-67					384:388	DB-67	384:388	DB-67	384:388	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	1	theme	Direct	368:373	arg1	Blue-67					375:381	Direct Blue-67	368:381	Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH)	368:468	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	6	2	theme	two-step	971:978	arg1	equation					985:992	the two-step rate equation	967:992	the two-step rate equation	967:992	The results revealed that the two-step rate equation was followed for the desorption kinetics of dyes.
32057879	7	3	theme	dyes	1143:1146	arg1	adsorption					1129:1138	the adsorption	1125:1138	the adsorption of dyes onto biomasses	1125:1161	The involvement of -OH (hydroxyl), -COOH (carboxylic) and -NH2 (amino) groups in the adsorption of dyes onto biomasses was shown by FTIR analysis.
32057879	2	4	dep	native	437:442	arg1	modified					445:452	modified	445:452	modified	445:452	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	5	theme	experimental	601:612	arg1	conditions					614:623	different experimental conditions	591:623	different experimental conditions	591:623	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	1	6	theme	water	200:204	arg1	resources					206:214	the water resources	196:214	the water resources	196:214	Rapid industrialization is polluting the water resources and is becoming a serious environmental issue.
32057879	5	7	theme	1st	867:869	arg1	order					871:875	1st order	867:875	1st order	867:875	The sorption data were optimized using pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models.
32057879	0	8	theme	kinetics	127:134	arg1	studies					150:156	Adsorption/desorption, kinetics and recycling studies	104:156	Adsorption/desorption, kinetics and recycling studies	104:156	Efficient removal of dyes using carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite: Adsorption/desorption, kinetics and recycling studies.
32057879	2	9	theme	alginate	530:537	arg1	behavior					307:314	the adsorption-desorption behavior	281:314	the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses	281:565	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	10	theme	different	591:599	arg1	conditions					614:623	different experimental conditions	591:623	different experimental conditions	591:623	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	4	11	theme	HCl	727:729	arg1	pre-treatment					731:743	HCl pre-treatment	727:743	HCl pre-treatment	727:743	The results showed that HCl pre-treatment considerably increased the sorption capacity of dyes versus native biomass.
32057879	2	12	dep	Orange-26	326:334	arg1	biomasses					557:565	immobilized biomasses	545:565	immobilized biomasses	545:565	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	13	theme	alcohol	481:487	arg1	behavior					307:314	the adsorption-desorption behavior	281:314	the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses	281:565	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	14	theme	Orange-26	326:334	arg1	behavior					307:314	the adsorption-desorption behavior	281:314	the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses	281:565	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	5	15	theme	pseudo	904:909	arg1	order					915:919	pseudo 2nd order	904:919	pseudo 2nd order	904:919	The sorption data were optimized using pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models.
32057879	2	16	theme	polyvinyl	471:479	arg1	PVA					490:492	PVA	490:492	PVA	490:492	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	16	theme	polyvinyl	471:479	arg1	alcohol					481:487	polyvinyl alcohol	471:487	polyvinyl alcohol (PVA)	471:493	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	7	17	theme	-OH	1063:1065	arg1	involvement					1048:1058	The involvement	1044:1058	The involvement of -OH (hydroxyl), -COOH (carboxylic) and -NH2 (amino) groups in the adsorption of dyes onto biomasses	1044:1161	The involvement of -OH (hydroxyl), -COOH (carboxylic) and -NH2 (amino) groups in the adsorption of dyes onto biomasses was shown by FTIR analysis.
32057879	6	18	theme	desorption	1015:1024	arg1	kinetics					1026:1033	the desorption kinetics	1011:1033	the desorption kinetics of dyes	1011:1041	The results revealed that the two-step rate equation was followed for the desorption kinetics of dyes.
32057879	2	19	theme	Direct	319:324	arg1	Orange-26					326:334	Direct Orange-26	319:334	Direct Orange-26 (DO-26)	319:342	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	19	theme	Direct	319:324	arg1	DO-26					337:341	DO-26	337:341	DO-26	337:341	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	8	20	dep	dyes	1285:1288	arg1	degradation					1290:1300	degradation	1290:1300	degradation	1290:1300	Studies exhibited that among adsorbents employed, the MRH has the excellent potential for the dyes degradation from textile effluents.
32057879	2	21	theme	native	437:442	arg1	husk					459:462	native, modified rice husk	437:462	native, modified rice husk	437:462	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	3	22	theme	chemical	667:674	arg1	treatments					676:685	physical and chemical treatments	654:685	physical and chemical treatments	654:685	For adsorbent modification, physical and chemical treatments were performed.
32057879	2	23	theme	rice	454:457	arg1	husk					459:462	native, modified rice husk	437:462	native, modified rice husk	437:462	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	5	24	theme	order	871:875	arg1	models					933:938	pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models	860:938	pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models	860:938	The sorption data were optimized using pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models.
32057879	8	25	from	effluents	1315:1323	arg1	degradation					1290:1300	degradation	1290:1300	degradation	1290:1300	Studies exhibited that among adsorbents employed, the MRH has the excellent potential for the dyes degradation from textile effluents.
32057879	0	26	theme	recycling	140:148	arg1	studies					150:156	Adsorption/desorption, kinetics and recycling studies	104:156	Adsorption/desorption, kinetics and recycling studies	104:156	Efficient removal of dyes using carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite: Adsorption/desorption, kinetics and recycling studies.
32057879	7	27	theme	amino	1108:1112	arg1	groups					1115:1120	-NH2 (amino) groups	1102:1120	-NH2 (amino) groups	1102:1120	The involvement of -OH (hydroxyl), -COOH (carboxylic) and -NH2 (amino) groups in the adsorption of dyes onto biomasses was shown by FTIR analysis.
32057879	2	28	theme	immobilized	545:555	arg1	biomasses					557:565	immobilized biomasses	545:565	immobilized biomasses	545:565	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	29	theme	Direct	345:350	arg1	DR-31					360:364	DR-31	360:364	DR-31	360:364	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	29	theme	Direct	345:350	arg1	Red-31					352:357	Direct Red-31	345:357	Direct Red-31 (DR-31)	345:365	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	6	30	theme	dyes	1038:1041	arg1	kinetics					1026:1033	the desorption kinetics	1011:1033	the desorption kinetics of dyes	1011:1041	The results revealed that the two-step rate equation was followed for the desorption kinetics of dyes.
32057879	0	31	theme	Efficient	0:8	arg1	removal					10:16	Efficient removal	0:16	Efficient removal of dyes using carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite	0:101	Efficient removal of dyes using carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite: Adsorption/desorption, kinetics and recycling studies.
32057879	7	32	from	involvement	1048:1058	arg1	adsorption					1129:1138	the adsorption	1125:1138	the adsorption of dyes onto biomasses	1125:1161	The involvement of -OH (hydroxyl), -COOH (carboxylic) and -NH2 (amino) groups in the adsorption of dyes onto biomasses was shown by FTIR analysis.
32057879	5	33	theme	order	915:919	arg1	models					933:938	pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models	860:938	pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models	860:938	The sorption data were optimized using pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models.
32057879	7	34	theme	-COOH	1079:1083	arg1	involvement					1048:1058	The involvement	1044:1058	The involvement of -OH (hydroxyl), -COOH (carboxylic) and -NH2 (amino) groups in the adsorption of dyes onto biomasses	1044:1161	The involvement of -OH (hydroxyl), -COOH (carboxylic) and -NH2 (amino) groups in the adsorption of dyes onto biomasses was shown by FTIR analysis.
32057879	0	35	theme	dyes	21:24	arg1	removal					10:16	Efficient removal	0:16	Efficient removal of dyes using carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite	0:101	Efficient removal of dyes using carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite: Adsorption/desorption, kinetics and recycling studies.
32057879	2	36	theme	carboxymethyl	496:508	arg1	CMC					521:523	CMC	521:523	CMC	521:523	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	36	theme	carboxymethyl	496:508	arg1	cellulose					510:518	carboxymethyl cellulose	496:518	carboxymethyl cellulose (CMC)	496:524	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	37	theme	EDO-3	419:423	arg1	dyes					426:429	direct Orange-3GL (EDO-3) dyes	400:429	Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH)	368:468	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	7	38	dep	-COOH	1079:1083	arg1	carboxylic					1086:1095	carboxylic	1086:1095	carboxylic	1086:1095	The involvement of -OH (hydroxyl), -COOH (carboxylic) and -NH2 (amino) groups in the adsorption of dyes onto biomasses was shown by FTIR analysis.
32057879	8	39	contain	has	1249:1251	arg1	MRH					1245:1247	the MRH	1241:1247	the MRH	1241:1247	Studies exhibited that among adsorbents employed, the MRH has the excellent potential for the dyes degradation from textile effluents.
32057879	8	39	contain	has	1249:1251	arg2	potential					1267:1275	the excellent potential	1253:1275	the excellent potential for the dyes degradation from textile effluents	1253:1323	Studies exhibited that among adsorbents employed, the MRH has the excellent potential for the dyes degradation from textile effluents.
32057879	0	40	dep	studies	150:156	arg1	removal					10:16	Efficient removal	0:16	Efficient removal of dyes using carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite	0:101	Efficient removal of dyes using carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite: Adsorption/desorption, kinetics and recycling studies.
32057879	1	41	theme	serious	234:240	arg1	issue					256:260	a serious environmental issue	232:260	a serious environmental issue	232:260	Rapid industrialization is polluting the water resources and is becoming a serious environmental issue.
32057879	0	42	theme	carboxymethyl	32:44	arg1	composite					93:101	carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite	32:101	carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite	32:101	Efficient removal of dyes using carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite: Adsorption/desorption, kinetics and recycling studies.
32057879	7	43	theme	groups	1115:1120	arg1	involvement					1048:1058	The involvement	1044:1058	The involvement of -OH (hydroxyl), -COOH (carboxylic) and -NH2 (amino) groups in the adsorption of dyes onto biomasses	1044:1161	The involvement of -OH (hydroxyl), -COOH (carboxylic) and -NH2 (amino) groups in the adsorption of dyes onto biomasses was shown by FTIR analysis.
32057879	1	44	theme	environmental	242:254	arg1	issue					256:260	a serious environmental issue	232:260	a serious environmental issue	232:260	Rapid industrialization is polluting the water resources and is becoming a serious environmental issue.
32057879	4	45	theme	dyes	793:796	arg1	capacity					781:788	the sorption capacity	768:788	the sorption capacity of dyes versus native biomass	768:818	The results showed that HCl pre-treatment considerably increased the sorption capacity of dyes versus native biomass.
32057879	2	46	theme	Orange-3GL	407:416	arg1	dyes					426:429	direct Orange-3GL (EDO-3) dyes	400:429	Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH)	368:468	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	47	theme	present	266:272	arg1	study					274:278	present study	266:278	present study	266:278	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	48	theme	direct	400:405	arg1	dyes					426:429	direct Orange-3GL (EDO-3) dyes	400:429	Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH)	368:468	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	0	49	theme	alcohol/rice	75:86	arg1	composite					93:101	carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite	32:101	carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite	32:101	Efficient removal of dyes using carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite: Adsorption/desorption, kinetics and recycling studies.
32057879	5	50	theme	pseudo	860:865	arg1	models					933:938	pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models	860:938	pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models	860:938	The sorption data were optimized using pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models.
32057879	8	51	theme	excellent	1257:1265	arg1	potential					1267:1275	the excellent potential	1253:1275	the excellent potential for the dyes degradation from textile effluents	1253:1323	Studies exhibited that among adsorbents employed, the MRH has the excellent potential for the dyes degradation from textile effluents.
32057879	4	52	theme	native	805:810	arg1	biomass					812:818	native biomass	805:818	native biomass	805:818	The results showed that HCl pre-treatment considerably increased the sorption capacity of dyes versus native biomass.
32057879	5	53	theme	intra-particle	878:891	arg1	diffusion					893:901	intra-particle diffusion	878:901	intra-particle diffusion	878:901	The sorption data were optimized using pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models.
32057879	0	54	theme	cellulose/alginate/polyvinyl	46:73	arg1	composite					93:101	carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite	32:101	carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite	32:101	Efficient removal of dyes using carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite: Adsorption/desorption, kinetics and recycling studies.
32057879	4	55	theme	biomass	812:818	arg1	capacity					781:788	the sorption capacity	768:788	the sorption capacity of dyes versus native biomass	768:818	The results showed that HCl pre-treatment considerably increased the sorption capacity of dyes versus native biomass.
32057879	5	56	theme	diffusion	893:901	arg1	models					933:938	pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models	860:938	pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models	860:938	The sorption data were optimized using pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models.
32057879	7	57	theme	FTIR	1176:1179	arg1	analysis					1181:1188	FTIR analysis	1176:1188	FTIR analysis	1176:1188	The involvement of -OH (hydroxyl), -COOH (carboxylic) and -NH2 (amino) groups in the adsorption of dyes onto biomasses was shown by FTIR analysis.
32057879	5	58	theme	2nd	911:913	arg1	order					915:919	pseudo 2nd order	904:919	pseudo 2nd order	904:919	The sorption data were optimized using pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models.
32057879	3	59	theme	adsorbent	630:638	arg1	modification					640:651	adsorbent modification	630:651	adsorbent modification	630:651	For adsorbent modification, physical and chemical treatments were performed.
32057879	8	60	theme	textile	1307:1313	arg1	effluents					1315:1323	textile effluents	1307:1323	textile effluents	1307:1323	Studies exhibited that among adsorbents employed, the MRH has the excellent potential for the dyes degradation from textile effluents.
32057879	1	61	theme	Rapid	159:163	arg1	industrialization					165:181	Rapid industrialization	159:181	Rapid industrialization	159:181	Rapid industrialization is polluting the water resources and is becoming a serious environmental issue.
32057879	2	62	theme	cellulose	510:518	arg1	behavior					307:314	the adsorption-desorption behavior	281:314	the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses	281:565	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	63	theme	adsorption-desorption	285:305	arg1	behavior					307:314	the adsorption-desorption behavior	281:314	the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses	281:565	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	2	64	theme	Red-31	352:357	arg1	behavior					307:314	the adsorption-desorption behavior	281:314	the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses	281:565	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	7	65	theme	-NH2	1102:1105	arg1	groups					1115:1120	-NH2 (amino) groups	1102:1120	-NH2 (amino) groups	1102:1120	The involvement of -OH (hydroxyl), -COOH (carboxylic) and -NH2 (amino) groups in the adsorption of dyes onto biomasses was shown by FTIR analysis.
32057879	5	66	theme	sorption	825:832	arg1	data					834:837	The sorption data	821:837	The sorption data	821:837	The sorption data were optimized using pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models.
32057879	5	67	theme	Elovich	925:931	arg1	models					933:938	pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models	860:938	pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models	860:938	The sorption data were optimized using pseudo 1st order, intra-particle diffusion, pseudo 2nd order and Elovich models.
32057879	0	68	theme	husk	88:91	arg1	composite					93:101	carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite	32:101	carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite	32:101	Efficient removal of dyes using carboxymethyl cellulose/alginate/polyvinyl alcohol/rice husk composite: Adsorption/desorption, kinetics and recycling studies.
32057879	3	69	theme	physical	654:661	arg1	treatments					676:685	physical and chemical treatments	654:685	physical and chemical treatments	654:685	For adsorbent modification, physical and chemical treatments were performed.
32057879	4	70	theme	sorption	772:779	arg1	capacity					781:788	the sorption capacity	768:788	the sorption capacity of dyes versus native biomass	768:818	The results showed that HCl pre-treatment considerably increased the sorption capacity of dyes versus native biomass.
32057879	2	71	theme	Blue-67	375:381	arg1	behavior					307:314	the adsorption-desorption behavior	281:314	the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses	281:565	In present study, the adsorption-desorption behavior of Direct Orange-26 (DO-26), Direct Red-31 (DR-31), Direct Blue-67 (DB-67) and Ever direct Orange-3GL (EDO-3) dyes on to native, modified rice husk (MRH), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) and alginate (ALG) immobilized biomasses were investigated under different experimental conditions.
32057879	6	72	theme	rate	980:983	arg1	equation					985:992	the two-step rate equation	967:992	the two-step rate equation	967:992	The results revealed that the two-step rate equation was followed for the desorption kinetics of dyes.
33710229	0	0	theme	suspensions	82:92	arg1	rheology					64:71	and the rheology	56:71	rheology	64:71	Simple production of cellulose nanofibril microcapsules and the rheology of their suspensions.
33710229	2	1	theme	microcapsules	519:531	arg1	suspensions					490:500	suspensions	490:500	suspensions of the resulting microcapsules	490:531	Here, we demonstrate a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine, and investigate the rheological properties of suspensions of the resulting microcapsules.
33710229	4	2	theme	yield	893:897	arg1	stresses					899:906	yield stresses	893:906	yield stresses	893:906	When polyacrylic acid (PAA) is added to the internal phase of the microcapsules, however, the suspensions become elastic and display yield stresses with power-law dependencies on capsule volume fraction and PAA concentration.
33710229	1	3	theme	porous	262:267	arg1	shells					269:274	their porous shells	256:274	their porous shells	256:274	Microcapsules are commonly used in applications ranging from therapeutics to personal care products due to their ability to deliver encapsulated species through their porous shells.
33710229	2	4	theme	resulting	509:517	arg1	microcapsules					519:531	the resulting microcapsules	505:531	the resulting microcapsules	505:531	Here, we demonstrate a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine, and investigate the rheological properties of suspensions of the resulting microcapsules.
33710229	3	5	theme	intrinsic	732:740	arg1	viscosity					742:750	an intrinsic viscosity	729:750	an intrinsic viscosity of 4.1	729:757	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	1	6	theme	personal	172:179	arg1	products					186:193	personal care products	172:193	personal care products	172:193	Microcapsules are commonly used in applications ranging from therapeutics to personal care products due to their ability to deliver encapsulated species through their porous shells.
33710229	2	7	theme	porous	361:366	arg1	shells					368:373	porous shells	361:373	porous shells	361:373	Here, we demonstrate a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine, and investigate the rheological properties of suspensions of the resulting microcapsules.
33710229	3	8	with	relation	676:683	arg1	fraction					708:715	a maximum packing fraction	690:715	a maximum packing fraction of 0.74	690:723	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	3	8	with	relation	676:683	arg1	viscosity					742:750	an intrinsic viscosity	729:750	an intrinsic viscosity of 4.1	729:757	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	2	9	theme	simple	300:305	arg1	approach					320:327	a simple and scalable approach	298:327	a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine	298:441	Here, we demonstrate a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine, and investigate the rheological properties of suspensions of the resulting microcapsules.
33710229	6	10	theme	microcapsule	1235:1246	arg1	suspensions					1248:1258	microcapsule suspensions	1235:1258	microcapsule suspensions	1235:1258	These results demonstrate that it is possible to tune the rheological properties of microcapsule suspensions by changing only the composition of the internal phase, thereby providing a novel method to tailor complex fluid rheology.
33710229	4	11	theme	internal	804:811	arg1	phase					813:817	the internal phase	800:817	the internal phase of the microcapsules	800:838	When polyacrylic acid (PAA) is added to the internal phase of the microcapsules, however, the suspensions become elastic and display yield stresses with power-law dependencies on capsule volume fraction and PAA concentration.
33710229	1	12	theme	care	181:184	arg1	products					186:193	personal care products	172:193	personal care products	172:193	Microcapsules are commonly used in applications ranging from therapeutics to personal care products due to their ability to deliver encapsulated species through their porous shells.
33710229	2	13	theme	rheological	464:474	arg1	properties					476:485	the rheological properties	460:485	the rheological properties of suspensions of the resulting microcapsules	460:531	Here, we demonstrate a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine, and investigate the rheological properties of suspensions of the resulting microcapsules.
33710229	2	14	theme	cellulose	406:414	arg1	nanofibrils					416:426	cellulose nanofibrils	406:426	cellulose nanofibrils	406:426	Here, we demonstrate a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine, and investigate the rheological properties of suspensions of the resulting microcapsules.
33710229	6	15	theme	rheological	1209:1219	arg1	properties					1221:1230	the rheological properties	1205:1230	the rheological properties of microcapsule suspensions	1205:1258	These results demonstrate that it is possible to tune the rheological properties of microcapsule suspensions by changing only the composition of the internal phase, thereby providing a novel method to tailor complex fluid rheology.
33710229	6	16	theme	fluid	1367:1371	arg1	rheology					1373:1380	complex fluid rheology	1359:1380	complex fluid rheology	1359:1380	These results demonstrate that it is possible to tune the rheological properties of microcapsule suspensions by changing only the composition of the internal phase, thereby providing a novel method to tailor complex fluid rheology.
33710229	0	17	theme	Simple	0:5	arg1	production					7:16	Simple production	0:16	Simple production of cellulose nanofibril	0:40	Simple production of cellulose nanofibril microcapsules and the rheology of their suspensions.
33710229	6	18	theme	phase	1309:1313	arg1	composition					1281:1291	only the composition	1272:1291	only the composition of the internal phase	1272:1313	These results demonstrate that it is possible to tune the rheological properties of microcapsule suspensions by changing only the composition of the internal phase, thereby providing a novel method to tailor complex fluid rheology.
33710229	2	19	theme	scalable	311:318	arg1	approach					320:327	a simple and scalable approach	298:327	a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine	298:441	Here, we demonstrate a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine, and investigate the rheological properties of suspensions of the resulting microcapsules.
33710229	0	20	theme	cellulose	21:29	arg1	nanofibril					31:40	cellulose nanofibril	21:40	cellulose nanofibril	21:40	Simple production of cellulose nanofibril microcapsules and the rheology of their suspensions.
33710229	4	21	theme	microcapsules	826:838	arg1	phase					813:817	the internal phase	800:817	the internal phase of the microcapsules	800:838	When polyacrylic acid (PAA) is added to the internal phase of the microcapsules, however, the suspensions become elastic and display yield stresses with power-law dependencies on capsule volume fraction and PAA concentration.
33710229	3	22	theme	volume	618:623	arg1	fraction					625:632	volume fraction	618:632	volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1	618:757	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	6	23	theme	suspensions	1248:1258	arg1	properties					1221:1230	the rheological properties	1205:1230	the rheological properties of microcapsule suspensions	1205:1258	These results demonstrate that it is possible to tune the rheological properties of microcapsule suspensions by changing only the composition of the internal phase, thereby providing a novel method to tailor complex fluid rheology.
33710229	4	24	theme	volume	947:952	arg1	fraction					954:961	capsule volume fraction	939:961	capsule volume fraction	939:961	When polyacrylic acid (PAA) is added to the internal phase of the microcapsules, however, the suspensions become elastic and display yield stresses with power-law dependencies on capsule volume fraction and PAA concentration.
33710229	3	25	theme	packing	700:706	arg1	fraction					708:715	a maximum packing fraction	690:715	a maximum packing fraction of 0.74	690:723	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	1	26	used	used	122:125	arg2	Microcapsules					95:107	Microcapsules	95:107	Microcapsules	95:107	Microcapsules are commonly used in applications ranging from therapeutics to personal care products due to their ability to deliver encapsulated species through their porous shells.
33710229	3	27	theme	neat	553:556	arg1	capsules					558:565	neat capsules	553:565	neat capsules	553:565	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	4	28	theme	PAA	967:969	arg1	concentration					971:983	PAA concentration	967:983	PAA concentration	967:983	When polyacrylic acid (PAA) is added to the internal phase of the microcapsules, however, the suspensions become elastic and display yield stresses with power-law dependencies on capsule volume fraction and PAA concentration.
33710229	6	29	theme	internal	1300:1307	arg1	phase					1309:1313	the internal phase	1296:1313	the internal phase	1296:1313	These results demonstrate that it is possible to tune the rheological properties of microcapsule suspensions by changing only the composition of the internal phase, thereby providing a novel method to tailor complex fluid rheology.
33710229	2	30	theme	oleylamine	432:441	arg1	complexation					390:401	interfacial complexation	378:401	interfacial complexation of cellulose nanofibrils and oleylamine	378:441	Here, we demonstrate a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine, and investigate the rheological properties of suspensions of the resulting microcapsules.
33710229	2	31	theme	nanofibrils	416:426	arg1	complexation					390:401	interfacial complexation	378:401	interfacial complexation of cellulose nanofibrils and oleylamine	378:441	Here, we demonstrate a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine, and investigate the rheological properties of suspensions of the resulting microcapsules.
33710229	0	32	theme	nanofibril	31:40	arg1	production					7:16	Simple production	0:16	Simple production of cellulose nanofibril	0:40	Simple production of cellulose nanofibril microcapsules and the rheology of their suspensions.
33710229	5	33	theme	microcapsule	1131:1142	arg1	shell					1144:1148	the microcapsule shell	1127:1148	the microcapsule shell	1127:1148	The elasticity appears to originate from associative microcapsule interactions induced by PAA that is contained within and incorporated into the microcapsule shell.
33710229	2	34	theme	suspensions	490:500	arg1	properties					476:485	the rheological properties	460:485	the rheological properties of suspensions of the resulting microcapsules	460:531	Here, we demonstrate a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine, and investigate the rheological properties of suspensions of the resulting microcapsules.
33710229	2	35	with	microcapsules	342:354	arg1	shells					368:373	porous shells	361:373	porous shells	361:373	Here, we demonstrate a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine, and investigate the rheological properties of suspensions of the resulting microcapsules.
33710229	6	36	theme	complex	1359:1365	arg1	rheology					1373:1380	complex fluid rheology	1359:1380	complex fluid rheology	1359:1380	These results demonstrate that it is possible to tune the rheological properties of microcapsule suspensions by changing only the composition of the internal phase, thereby providing a novel method to tailor complex fluid rheology.
33710229	4	37	theme	power-law	913:921	arg1	dependencies					923:934	power-law dependencies	913:934	power-law dependencies on capsule volume fraction and PAA concentration	913:983	When polyacrylic acid (PAA) is added to the internal phase of the microcapsules, however, the suspensions become elastic and display yield stresses with power-law dependencies on capsule volume fraction and PAA concentration.
33710229	3	38	theme	maximum	692:698	arg1	fraction					708:715	a maximum packing fraction	690:715	a maximum packing fraction of 0.74	690:723	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	6	39	theme	novel	1336:1340	arg1	method					1342:1347	a novel method	1334:1347	a novel method to tailor complex fluid rheology	1334:1380	These results demonstrate that it is possible to tune the rheological properties of microcapsule suspensions by changing only the composition of the internal phase, thereby providing a novel method to tailor complex fluid rheology.
33710229	4	40	theme	capsule	939:945	arg1	fraction					954:961	capsule volume fraction	939:961	capsule volume fraction	939:961	When polyacrylic acid (PAA) is added to the internal phase of the microcapsules, however, the suspensions become elastic and display yield stresses with power-law dependencies on capsule volume fraction and PAA concentration.
33710229	5	41	theme	associative	1027:1037	arg1	interactions					1052:1063	associative microcapsule interactions	1027:1063	associative microcapsule interactions induced by PAA that is contained within and incorporated into the microcapsule shell	1027:1148	The elasticity appears to originate from associative microcapsule interactions induced by PAA that is contained within and incorporated into the microcapsule shell.
33710229	1	42	theme	encapsulated	227:238	arg1	species					240:246	encapsulated species	227:246	encapsulated species	227:246	Microcapsules are commonly used in applications ranging from therapeutics to personal care products due to their ability to deliver encapsulated species through their porous shells.
33710229	3	43	theme	viscous	571:577	arg1	liquids					579:585	viscous liquids	571:585	viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1	571:757	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	3	43	theme	viscous	571:577	arg1	suspensions					538:548	The suspensions	534:548	The suspensions of neat capsules	534:565	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	4	44	from	dependencies	923:934	arg1	fraction					954:961	capsule volume fraction	939:961	capsule volume fraction	939:961	When polyacrylic acid (PAA) is added to the internal phase of the microcapsules, however, the suspensions become elastic and display yield stresses with power-law dependencies on capsule volume fraction and PAA concentration.
33710229	4	44	from	dependencies	923:934	arg1	concentration					971:983	PAA concentration	967:983	PAA concentration	967:983	When polyacrylic acid (PAA) is added to the internal phase of the microcapsules, however, the suspensions become elastic and display yield stresses with power-law dependencies on capsule volume fraction and PAA concentration.
33710229	5	45	theme	microcapsule	1039:1050	arg1	interactions					1052:1063	associative microcapsule interactions	1027:1063	associative microcapsule interactions induced by PAA that is contained within and incorporated into the microcapsule shell	1027:1148	The elasticity appears to originate from associative microcapsule interactions induced by PAA that is contained within and incorporated into the microcapsule shell.
33710229	4	46	theme	polyacrylic	765:775	arg1	PAA					783:785	PAA	783:785	PAA	783:785	When polyacrylic acid (PAA) is added to the internal phase of the microcapsules, however, the suspensions become elastic and display yield stresses with power-law dependencies on capsule volume fraction and PAA concentration.
33710229	4	46	theme	polyacrylic	765:775	arg1	acid					777:780	polyacrylic acid	765:780	polyacrylic acid (PAA)	765:786	When polyacrylic acid (PAA) is added to the internal phase of the microcapsules, however, the suspensions become elastic and display yield stresses with power-law dependencies on capsule volume fraction and PAA concentration.
33710229	3	47	theme	0.74	720:723	arg1	fraction					708:715	a maximum packing fraction	690:715	a maximum packing fraction of 0.74	690:723	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	3	47	theme	0.74	720:723	arg1	viscosity					742:750	an intrinsic viscosity	729:750	an intrinsic viscosity of 4.1	729:757	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	3	48	theme	modified	649:656	arg1	relation					676:683	a modified Kreiger-Dougherty relation	647:683	a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1	647:757	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	2	49	theme	interfacial	378:388	arg1	complexation					390:401	interfacial complexation	378:401	interfacial complexation of cellulose nanofibrils and oleylamine	378:441	Here, we demonstrate a simple and scalable approach to fabricate microcapsules with porous shells by interfacial complexation of cellulose nanofibrils and oleylamine, and investigate the rheological properties of suspensions of the resulting microcapsules.
33710229	3	50	theme	Kreiger-Dougherty	658:674	arg1	relation					676:683	a modified Kreiger-Dougherty relation	647:683	a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1	647:757	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	3	51	theme	4.1	755:757	arg1	fraction					708:715	a maximum packing fraction	690:715	a maximum packing fraction of 0.74	690:723	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	3	51	theme	4.1	755:757	arg1	viscosity					742:750	an intrinsic viscosity	729:750	an intrinsic viscosity of 4.1	729:757	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	3	52	theme	capsules	558:565	arg1	liquids					579:585	viscous liquids	571:585	viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1	571:757	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33710229	3	52	theme	capsules	558:565	arg1	suspensions					538:548	The suspensions	534:548	The suspensions of neat capsules	534:565	The suspensions of neat capsules are viscous liquids whose viscosity increases with volume fraction according to a modified Kreiger-Dougherty relation with a maximum packing fraction of 0.74 and an intrinsic viscosity of 4.1.
33737184	6	0	theme	scanning	1021:1028	arg1	DSC					1043:1045	DSC	1043:1045	DSC	1043:1045	The thermal properties of polyurethane composites were carried out using thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC).
33737184	6	0	theme	scanning	1021:1028	arg1	calorimeter					1030:1040	differential scanning calorimeter	1008:1040	differential scanning calorimeter (DSC)	1008:1046	The thermal properties of polyurethane composites were carried out using thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC).
33737184	1	1	theme	bio-composites	180:193	arg1	properties					152:161	the structural properties	137:161	the structural properties of polyurethanes bio-composites	137:193	The present work aims to examine the structural properties of polyurethanes bio-composites with mole ratios of alginate and chitosan.
33737184	6	2	theme	thermogravimetric	971:987	arg1	TGA					999:1001	TGA	999:1001	TGA	999:1001	The thermal properties of polyurethane composites were carried out using thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC).
33737184	6	2	theme	thermogravimetric	971:987	arg1	analysis					989:996	thermogravimetric analysis	971:996	thermogravimetric analysis (TGA)	971:1002	The thermal properties of polyurethane composites were carried out using thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC).
33737184	7	3	theme	RPU-5	1098:1102	arg1	stability					1085:1093	thermal stability	1077:1093	thermal stability of RPU-5	1077:1102	The TGA results showed that thermal stability of RPU-5 was 20 °C more than RPU-1 at each corresponding degradation temperature.
33737184	9	4	theme	thermal	1399:1405	arg1	properties					1407:1416	better thermal properties	1392:1416	better thermal properties	1392:1416	Overall, CS based samples along with small amount of ALG showed better thermal properties.
33737184	4	5	theme	1H	731:732	arg1	resonance					720:728	proton nuclear magnetic resonance	696:728	proton nuclear magnetic resonance (1H NMR) spectroscopy	696:750	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	4	5	theme	1H	731:732	arg1	NMR					734:736	1H NMR	731:736	1H NMR	731:736	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	9	6	theme	ALG	1381:1383	arg1	ALG					1381:1383	ALG	1381:1383	ALG	1381:1383	Overall, CS based samples along with small amount of ALG showed better thermal properties.
33737184	9	6	theme	ALG	1381:1383	arg1	amount					1371:1376	small amount	1365:1376	small amount of ALG	1365:1383	Overall, CS based samples along with small amount of ALG showed better thermal properties.
33737184	4	7	theme	nuclear	703:709	arg1	resonance					720:728	proton nuclear magnetic resonance	696:728	proton nuclear magnetic resonance (1H NMR) spectroscopy	696:750	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	4	7	theme	nuclear	703:709	arg1	NMR					734:736	1H NMR	731:736	1H NMR	731:736	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	7	8	theme	thermal	1077:1083	arg1	stability					1085:1093	thermal stability	1077:1093	thermal stability of RPU-5	1077:1102	The TGA results showed that thermal stability of RPU-5 was 20 °C more than RPU-1 at each corresponding degradation temperature.
33737184	4	9	theme	Infra-red	674:682	arg1	FT-IR					685:689	FT-IR	685:689	FT-IR	685:689	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	5	10	theme	X-ray	821:825	arg1	diffraction					827:837	X-ray diffraction	821:837	X-ray diffraction (XRD) method	821:850	The crystallinity of the prepared samples was investigated by using X-ray diffraction (XRD) method, the maximum observed intensity was 7704 a.u.
33737184	5	10	theme	X-ray	821:825	arg1	XRD					840:842	XRD	840:842	XRD	840:842	The crystallinity of the prepared samples was investigated by using X-ray diffraction (XRD) method, the maximum observed intensity was 7704 a.u.
33737184	7	11	theme	corresponding	1138:1150	arg1	temperature					1164:1174	each corresponding degradation temperature	1133:1174	each corresponding degradation temperature	1133:1174	The TGA results showed that thermal stability of RPU-5 was 20 °C more than RPU-1 at each corresponding degradation temperature.
33737184	5	12	theme	maximum	857:863	arg1	7704 a.u.					888:896	7704 a.u.	888:896	7704 a.u.	888:896	The crystallinity of the prepared samples was investigated by using X-ray diffraction (XRD) method, the maximum observed intensity was 7704 a.u.
33737184	5	12	theme	maximum	857:863	arg1	intensity					874:882	the maximum observed intensity	853:882	the maximum observed intensity	853:882	The crystallinity of the prepared samples was investigated by using X-ray diffraction (XRD) method, the maximum observed intensity was 7704 a.u.
33737184	4	13	theme	Structural	594:603	arg1	elucidation					626:636	Structural and functional group elucidation	594:636	Structural and functional group elucidation	594:636	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	4	14	dep	Fourier	656:662	arg1	Transform					664:672	Transform	664:672	Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy	664:750	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	1	15	theme	mole	200:203	arg1	ratios					205:210	mole ratios	200:210	mole ratios of alginate and chitosan	200:235	The present work aims to examine the structural properties of polyurethanes bio-composites with mole ratios of alginate and chitosan.
33737184	7	16	theme	degradation	1152:1162	arg1	temperature					1164:1174	each corresponding degradation temperature	1133:1174	each corresponding degradation temperature	1133:1174	The TGA results showed that thermal stability of RPU-5 was 20 °C more than RPU-1 at each corresponding degradation temperature.
33737184	8	17	theme	melting	1266:1272	arg1	point					1274:1278	melting point	1266:1278	melting point	1266:1278	It is observed all physical parameters like crystallinity, glass transition temperature, melting point are much dependent on ratio of chain extenders.
33737184	8	17	theme	melting	1266:1272	arg1	crystallinity					1221:1233	crystallinity	1221:1233	crystallinity	1221:1233	It is observed all physical parameters like crystallinity, glass transition temperature, melting point are much dependent on ratio of chain extenders.
33737184	8	18	theme	extenders	1317:1325	arg1	ratio					1302:1306	ratio	1302:1306	ratio of chain extenders	1302:1325	It is observed all physical parameters like crystallinity, glass transition temperature, melting point are much dependent on ratio of chain extenders.
33737184	5	19	theme	diffraction	827:837	arg1	method					845:850	X-ray diffraction (XRD) method	821:850	X-ray diffraction (XRD) method	821:850	The crystallinity of the prepared samples was investigated by using X-ray diffraction (XRD) method, the maximum observed intensity was 7704 a.u.
33737184	1	20	theme	present	108:114	arg1	work					116:119	The present work	104:119	The present work	104:119	The present work aims to examine the structural properties of polyurethanes bio-composites with mole ratios of alginate and chitosan.
33737184	2	21	theme	polybutadiene	455:467	arg1	reaction					385:392	the reaction	381:392	the reaction of hexamethylene diisocyanate (HMDI) and hydroxyl-terminated polybutadiene (HTPB)	381:474	For this concern, a two-step reaction mechanism was carried out; in the first step isocyanate (-NCO) terminated pre-polymer was synthesized by the reaction of hexamethylene diisocyanate (HMDI) and hydroxyl-terminated polybutadiene (HTPB).
33737184	7	22	theme	TGA	1053:1055	arg1	results					1057:1063	The TGA results	1049:1063	The TGA results	1049:1063	The TGA results showed that thermal stability of RPU-5 was 20 °C more than RPU-1 at each corresponding degradation temperature.
33737184	4	23	theme	proton	696:701	arg1	resonance					720:728	proton nuclear magnetic resonance	696:728	proton nuclear magnetic resonance (1H NMR) spectroscopy	696:750	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	4	23	theme	proton	696:701	arg1	NMR					734:736	1H NMR	731:736	1H NMR	731:736	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	1	24	theme	alginate	215:222	arg1	ratios					205:210	mole ratios	200:210	mole ratios of alginate and chitosan	200:235	The present work aims to examine the structural properties of polyurethanes bio-composites with mole ratios of alginate and chitosan.
33737184	2	25	theme	hydroxyl-terminated	435:453	arg1	polybutadiene					455:467	hydroxyl-terminated polybutadiene	435:467	hydroxyl-terminated polybutadiene (HTPB)	435:474	For this concern, a two-step reaction mechanism was carried out; in the first step isocyanate (-NCO) terminated pre-polymer was synthesized by the reaction of hexamethylene diisocyanate (HMDI) and hydroxyl-terminated polybutadiene (HTPB).
33737184	2	25	theme	hydroxyl-terminated	435:453	arg1	HTPB					470:473	HTPB	470:473	HTPB	470:473	For this concern, a two-step reaction mechanism was carried out; in the first step isocyanate (-NCO) terminated pre-polymer was synthesized by the reaction of hexamethylene diisocyanate (HMDI) and hydroxyl-terminated polybutadiene (HTPB).
33737184	6	26	theme	composites	937:946	arg1	properties					910:919	The thermal properties	898:919	The thermal properties of polyurethane composites	898:946	The thermal properties of polyurethane composites were carried out using thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC).
33737184	9	27	theme	better	1392:1397	arg1	properties					1407:1416	better thermal properties	1392:1416	better thermal properties	1392:1416	Overall, CS based samples along with small amount of ALG showed better thermal properties.
33737184	4	28	theme	resonance	720:728	arg1	spectroscopy					739:750	proton nuclear magnetic resonance (1H NMR) spectroscopy	696:750	proton nuclear magnetic resonance (1H NMR) spectroscopy	696:750	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	8	29	theme	glass	1236:1240	arg1	crystallinity					1221:1233	crystallinity	1221:1233	crystallinity	1221:1233	It is observed all physical parameters like crystallinity, glass transition temperature, melting point are much dependent on ratio of chain extenders.
33737184	8	29	theme	glass	1236:1240	arg1	temperature					1253:1263	glass transition temperature	1236:1263	glass transition temperature	1236:1263	It is observed all physical parameters like crystallinity, glass transition temperature, melting point are much dependent on ratio of chain extenders.
33737184	0	30	theme	molecular	14:22	arg1	characterization					24:39	molecular characterization	14:39	molecular characterization	14:39	Synthesis and molecular characterization of chitosan/alginate blends based polyurethanes biocomposites.
33737184	6	31	theme	polyurethane	924:935	arg1	composites					937:946	polyurethane composites	924:946	polyurethane composites	924:946	The thermal properties of polyurethane composites were carried out using thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC).
33737184	4	32	theme	magnetic	711:718	arg1	resonance					720:728	proton nuclear magnetic resonance	696:728	proton nuclear magnetic resonance (1H NMR) spectroscopy	696:750	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	4	32	theme	magnetic	711:718	arg1	NMR					734:736	1H NMR	731:736	1H NMR	731:736	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	1	33	theme	chitosan	228:235	arg1	ratios					205:210	mole ratios	200:210	mole ratios of alginate and chitosan	200:235	The present work aims to examine the structural properties of polyurethanes bio-composites with mole ratios of alginate and chitosan.
33737184	0	34	theme	chitosan/alginate	44:60	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis and molecular characterization of chitosan/alginate blends based polyurethanes biocomposites.
33737184	0	34	theme	chitosan/alginate	44:60	arg1	characterization					24:39	molecular characterization	14:39	molecular characterization	14:39	Synthesis and molecular characterization of chitosan/alginate blends based polyurethanes biocomposites.
33737184	6	35	theme	differential	1008:1019	arg1	DSC					1043:1045	DSC	1043:1045	DSC	1043:1045	The thermal properties of polyurethane composites were carried out using thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC).
33737184	6	35	theme	differential	1008:1019	arg1	calorimeter					1030:1040	differential scanning calorimeter	1008:1040	differential scanning calorimeter (DSC)	1008:1046	The thermal properties of polyurethane composites were carried out using thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC).
33737184	4	36	theme	group	620:624	arg1	elucidation					626:636	Structural and functional group elucidation	594:636	Structural and functional group elucidation	594:636	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	2	37	theme	hexamethylene	397:409	arg1	HMDI					425:428	HMDI	425:428	HMDI	425:428	For this concern, a two-step reaction mechanism was carried out; in the first step isocyanate (-NCO) terminated pre-polymer was synthesized by the reaction of hexamethylene diisocyanate (HMDI) and hydroxyl-terminated polybutadiene (HTPB).
33737184	2	37	theme	hexamethylene	397:409	arg1	diisocyanate					411:422	hexamethylene diisocyanate	397:422	hexamethylene diisocyanate (HMDI)	397:429	For this concern, a two-step reaction mechanism was carried out; in the first step isocyanate (-NCO) terminated pre-polymer was synthesized by the reaction of hexamethylene diisocyanate (HMDI) and hydroxyl-terminated polybutadiene (HTPB).
33737184	9	38	theme	based	1340:1344	arg1	samples					1346:1352	CS based samples	1337:1352	CS based samples along with small amount of ALG	1337:1383	Overall, CS based samples along with small amount of ALG showed better thermal properties.
33737184	5	39	theme	prepared	778:785	arg1	samples					787:793	the prepared samples	774:793	the prepared samples	774:793	The crystallinity of the prepared samples was investigated by using X-ray diffraction (XRD) method, the maximum observed intensity was 7704 a.u.
33737184	2	40	theme	diisocyanate	411:422	arg1	reaction					385:392	the reaction	381:392	the reaction of hexamethylene diisocyanate (HMDI) and hydroxyl-terminated polybutadiene (HTPB)	381:474	For this concern, a two-step reaction mechanism was carried out; in the first step isocyanate (-NCO) terminated pre-polymer was synthesized by the reaction of hexamethylene diisocyanate (HMDI) and hydroxyl-terminated polybutadiene (HTPB).
33737184	0	41	theme	based	69:73	arg1	biocomposites					89:101	based polyurethanes biocomposites	69:101	based polyurethanes biocomposites	69:101	Synthesis and molecular characterization of chitosan/alginate blends based polyurethanes biocomposites.
33737184	6	42	theme	thermal	902:908	arg1	properties					910:919	The thermal properties	898:919	The thermal properties of polyurethane composites	898:946	The thermal properties of polyurethane composites were carried out using thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC).
33737184	8	43	theme	chain	1311:1315	arg1	extenders					1317:1325	chain extenders	1311:1325	chain extenders	1311:1325	It is observed all physical parameters like crystallinity, glass transition temperature, melting point are much dependent on ratio of chain extenders.
33737184	2	44	theme	terminated	339:348	arg1	pre-polymer					350:360	isocyanate (-NCO) terminated pre-polymer	321:360	isocyanate (-NCO) terminated pre-polymer	321:360	For this concern, a two-step reaction mechanism was carried out; in the first step isocyanate (-NCO) terminated pre-polymer was synthesized by the reaction of hexamethylene diisocyanate (HMDI) and hydroxyl-terminated polybutadiene (HTPB).
33737184	9	45	theme	CS	1337:1338	arg1	samples					1346:1352	CS based samples	1337:1352	CS based samples along with small amount of ALG	1337:1383	Overall, CS based samples along with small amount of ALG showed better thermal properties.
33737184	5	46	theme	observed	865:872	arg1	7704 a.u.					888:896	7704 a.u.	888:896	7704 a.u.	888:896	The crystallinity of the prepared samples was investigated by using X-ray diffraction (XRD) method, the maximum observed intensity was 7704 a.u.
33737184	5	46	theme	observed	865:872	arg1	intensity					874:882	the maximum observed intensity	853:882	the maximum observed intensity	853:882	The crystallinity of the prepared samples was investigated by using X-ray diffraction (XRD) method, the maximum observed intensity was 7704 a.u.
33737184	2	47	theme	two-step	258:265	arg1	mechanism					276:284	a two-step reaction mechanism	256:284	a two-step reaction mechanism	256:284	For this concern, a two-step reaction mechanism was carried out; in the first step isocyanate (-NCO) terminated pre-polymer was synthesized by the reaction of hexamethylene diisocyanate (HMDI) and hydroxyl-terminated polybutadiene (HTPB).
33737184	1	48	theme	structural	141:150	arg1	properties					152:161	the structural properties	137:161	the structural properties of polyurethanes bio-composites	137:193	The present work aims to examine the structural properties of polyurethanes bio-composites with mole ratios of alginate and chitosan.
33737184	2	49	theme	first	310:314	arg1	step					316:319	the first step	306:319	the first step	306:319	For this concern, a two-step reaction mechanism was carried out; in the first step isocyanate (-NCO) terminated pre-polymer was synthesized by the reaction of hexamethylene diisocyanate (HMDI) and hydroxyl-terminated polybutadiene (HTPB).
33737184	8	50	theme	transition	1242:1251	arg1	crystallinity					1221:1233	crystallinity	1221:1233	crystallinity	1221:1233	It is observed all physical parameters like crystallinity, glass transition temperature, melting point are much dependent on ratio of chain extenders.
33737184	8	50	theme	transition	1242:1251	arg1	temperature					1253:1263	glass transition temperature	1236:1263	glass transition temperature	1236:1263	It is observed all physical parameters like crystallinity, glass transition temperature, melting point are much dependent on ratio of chain extenders.
33737184	5	51	theme	samples	787:793	arg1	crystallinity					757:769	The crystallinity	753:769	The crystallinity of the prepared samples	753:793	The crystallinity of the prepared samples was investigated by using X-ray diffraction (XRD) method, the maximum observed intensity was 7704 a.u.
33737184	4	52	theme	functional	609:618	arg1	elucidation					626:636	Structural and functional group elucidation	594:636	Structural and functional group elucidation	594:636	Structural and functional group elucidation was done by using Fourier Transform Infra-red (FT-IR) and proton nuclear magnetic resonance (1H NMR) spectroscopy.
33737184	2	53	theme	reaction	267:274	arg1	mechanism					276:284	a two-step reaction mechanism	256:284	a two-step reaction mechanism	256:284	For this concern, a two-step reaction mechanism was carried out; in the first step isocyanate (-NCO) terminated pre-polymer was synthesized by the reaction of hexamethylene diisocyanate (HMDI) and hydroxyl-terminated polybutadiene (HTPB).
33737184	8	54	theme	physical	1196:1203	arg1	parameters					1205:1214	all physical parameters	1192:1214	all physical parameters like crystallinity, glass transition temperature, melting point	1192:1278	It is observed all physical parameters like crystallinity, glass transition temperature, melting point are much dependent on ratio of chain extenders.
33737184	0	55	theme	polyurethanes	75:87	arg1	biocomposites					89:101	based polyurethanes biocomposites	69:101	based polyurethanes biocomposites	69:101	Synthesis and molecular characterization of chitosan/alginate blends based polyurethanes biocomposites.
33737184	3	56	theme	second	581:586	arg1	step					588:591	the second step	577:591	the second step	577:591	The pre-polymer was further extended with 1,4-butanediol (BDO), chitosan (CS) and alginate (ALG) in the second step.
33737184	1	57	theme	polyurethanes	166:178	arg1	bio-composites					180:193	polyurethanes bio-composites	166:193	polyurethanes bio-composites	166:193	The present work aims to examine the structural properties of polyurethanes bio-composites with mole ratios of alginate and chitosan.
33737184	9	58	theme	small	1365:1369	arg1	ALG					1381:1383	ALG	1381:1383	ALG	1381:1383	Overall, CS based samples along with small amount of ALG showed better thermal properties.
33737184	9	58	theme	small	1365:1369	arg1	amount					1371:1376	small amount	1365:1376	small amount of ALG	1365:1383	Overall, CS based samples along with small amount of ALG showed better thermal properties.
34561124	2	0	theme	experimental	339:350	arg1	models					352:357	several in vivo experimental models	323:357	several in vivo experimental models	323:357	The anti-inflammatory activity of the plant extract has been reported in several in vivo experimental models.
34561124	9	1	theme	serum	1303:1307	arg1	levels					1309:1314	attenuated serum levels	1292:1314	attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10	1292:1393	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	12	2	theme	increased	1768:1776	arg1	barrier					1789:1795	an increased intestinal barrier	1765:1795	an increased intestinal barrier protective species (Akkermansia spp)	1765:1832	Moreover, SCF treatment ameliorated HFHS-induced gut dysbiosis, as revealed by an increased intestinal barrier protective species (Akkermansia spp).
34561124	6	3	from	cytokines	968:976	arg1	mice					981:984	mice	981:984	mice	981:984	The body weight, liver weight, serum concentrations of lipopolysaccharide (LPS), and inflammatory cytokines in mice were assessed.
34561124	12	4	theme	barrier	1789:1795	arg1	species					1808:1814	an increased intestinal barrier protective species	1765:1814	an increased intestinal barrier protective species (Akkermansia spp)	1765:1832	Moreover, SCF treatment ameliorated HFHS-induced gut dysbiosis, as revealed by an increased intestinal barrier protective species (Akkermansia spp).
34561124	12	4	theme	barrier	1789:1795	arg1	spp					1829:1831	spp	1829:1831	spp	1829:1831	Moreover, SCF treatment ameliorated HFHS-induced gut dysbiosis, as revealed by an increased intestinal barrier protective species (Akkermansia spp).
34561124	0	5	theme	Smilax	0:5	arg1	flavonoid					16:24	Smilax china L. flavonoid	0:24	Smilax china L. flavonoid	0:24	Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice.
34561124	9	6	theme	necrosis	1325:1332	arg1	factor					1334:1339	tumor necrosis factor (TNF)-α	1319:1347	tumor necrosis factor (TNF)-α	1319:1347	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	6	theme	necrosis	1325:1332	arg1	TNF					1342:1344	TNF	1342:1344	TNF	1342:1344	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	8	7	theme	gut	1143:1145	arg1	microbiota					1147:1156	gut microbiota	1143:1156	gut microbiota	1143:1156	Finally, the composition of gut microbiota was detected by analyzing 16S rDNA gene sequences.
34561124	11	8	theme	TLR4	1592:1595	arg1	levels					1640:1645	the TLR4, p-IκBα, NF-κB, and p65 protein expression levels	1588:1645	the TLR4, p-IκBα, NF-κB, and p65 protein expression levels	1588:1645	In addition, the TLR4, p-IκBα, NF-κB, and p65 protein expression levels were reduced after the SCF supplement.
34561124	4	9	from	microbiota	623:632	arg1	mice					680:683	high-fat/high-sucrose (HFHS)-induced obese mice	637:683	high-fat/high-sucrose (HFHS)-induced obese mice	637:683	PURPOSE To investigate the role of SCF in providing the anti-inflammatory response and the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks.
34561124	13	10	theme	endotoxin-producing	1899:1917	arg1	Desulfovibrionaceae					1919:1937	endotoxin-producing Desulfovibrionaceae	1899:1937	endotoxin-producing Desulfovibrionaceae	1899:1937	The relative abundance of Streptococcaceae, Faecalibaculum, and endotoxin-producing Desulfovibrionaceae were significantly decreased on SCF supplements.
34561124	2	11	theme	extract	294:300	arg1	activity					272:279	The anti-inflammatory activity	250:279	The anti-inflammatory activity of the plant extract	250:300	The anti-inflammatory activity of the plant extract has been reported in several in vivo experimental models.
34561124	12	12	theme	HFHS-induced	1722:1733	arg1	dysbiosis					1739:1747	HFHS-induced gut dysbiosis	1722:1747	HFHS-induced gut dysbiosis	1722:1747	Moreover, SCF treatment ameliorated HFHS-induced gut dysbiosis, as revealed by an increased intestinal barrier protective species (Akkermansia spp).
34561124	11	13	theme	SCF	1670:1672	arg1	supplement					1674:1683	the SCF supplement	1666:1683	the SCF supplement	1666:1683	In addition, the TLR4, p-IκBα, NF-κB, and p65 protein expression levels were reduced after the SCF supplement.
34561124	4	14	theme	microbiota	623:632	arg1	role					611:614	the role	607:614	the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks	607:696	PURPOSE To investigate the role of SCF in providing the anti-inflammatory response and the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks.
34561124	4	14	theme	microbiota	623:632	arg1	role					547:550	the role	543:550	the role of SCF in providing the anti-inflammatory response	543:601	PURPOSE To investigate the role of SCF in providing the anti-inflammatory response and the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks.
34561124	11	15	theme	NF-κB	1606:1610	arg1	levels					1640:1645	the TLR4, p-IκBα, NF-κB, and p65 protein expression levels	1588:1645	the TLR4, p-IκBα, NF-κB, and p65 protein expression levels	1588:1645	In addition, the TLR4, p-IκBα, NF-κB, and p65 protein expression levels were reduced after the SCF supplement.
34561124	16	16	from	axis	2432:2435	arg1	mice					2440:2443	mice	2440:2443	mice	2440:2443	Thus, SCF may be a promising prophylactic for diet-induced inflammatory diseases through the gut-liver axis in mice.
34561124	1	17	theme	inflammatory	192:203	arg1	disorders					205:213	various inflammatory disorders	184:213	various inflammatory disorders	184:213	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34561124	8	18	theme	16S	1184:1186	arg1	sequences					1198:1206	16S rDNA gene sequences	1184:1206	16S rDNA gene sequences	1184:1206	Finally, the composition of gut microbiota was detected by analyzing 16S rDNA gene sequences.
34561124	10	19	theme	expression	1448:1457	arg1	levels					1459:1464	the mRNA expression levels	1439:1464	the mRNA expression levels of TNF-α, IL-6	1439:1479	SCF significantly reduced the mRNA expression levels of TNF-α, IL-6, and increased the expression of AMPK, PPAR-γ, and IL-10 in mice's liver and adipose tissues.
34561124	11	20	theme	p-IκBα	1598:1603	arg1	levels					1640:1645	the TLR4, p-IκBα, NF-κB, and p65 protein expression levels	1588:1645	the TLR4, p-IκBα, NF-κB, and p65 protein expression levels	1588:1645	In addition, the TLR4, p-IκBα, NF-κB, and p65 protein expression levels were reduced after the SCF supplement.
34561124	15	21	theme	Akkermansia	2214:2224	arg1	spp					2226:2228	gut barrier protective species Akkermansia spp	2183:2228	gut barrier protective species Akkermansia spp	2183:2228	Furthermore, the abundance of gut barrier protective species Akkermansia spp was increased to alleviate inflammatory response, inhibiting the LPS-TLR4/NF-κB signaling pathway.
34561124	15	22	theme	spp	2226:2228	arg1	abundance					2170:2178	the abundance	2166:2178	the abundance of gut barrier protective species Akkermansia spp	2166:2228	Furthermore, the abundance of gut barrier protective species Akkermansia spp was increased to alleviate inflammatory response, inhibiting the LPS-TLR4/NF-κB signaling pathway.
34561124	1	23	theme	china	123:127	arg1	Smilax					116:121	BACKGROUND Smilax china L.	105:130	BACKGROUND Smilax china L.	105:130	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34561124	1	23	theme	china	123:127	arg1	herb					155:158	a traditional Chinese herb	133:158	a traditional Chinese herb	133:158	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34561124	1	24	used	used	170:173	arg2	herb					155:158	a traditional Chinese herb	133:158	a traditional Chinese herb	133:158	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34561124	1	24	used	used	170:173	arg2	Smilax					116:121	BACKGROUND Smilax china L.	105:130	BACKGROUND Smilax china L.	105:130	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34561124	8	25	theme	gene	1193:1196	arg1	sequences					1198:1206	16S rDNA gene sequences	1184:1206	16S rDNA gene sequences	1184:1206	Finally, the composition of gut microbiota was detected by analyzing 16S rDNA gene sequences.
34561124	15	26	theme	protective	2195:2204	arg1	spp					2226:2228	gut barrier protective species Akkermansia spp	2183:2228	gut barrier protective species Akkermansia spp	2183:2228	Furthermore, the abundance of gut barrier protective species Akkermansia spp was increased to alleviate inflammatory response, inhibiting the LPS-TLR4/NF-κB signaling pathway.
34561124	10	27	theme	adipose	1558:1564	arg1	tissues					1566:1572	adipose tissues	1558:1572	adipose tissues	1558:1572	SCF significantly reduced the mRNA expression levels of TNF-α, IL-6, and increased the expression of AMPK, PPAR-γ, and IL-10 in mice's liver and adipose tissues.
34561124	5	28	theme	high-	837:841	arg1	low-					822:825	low-	822:825	low-	822:825	STUDY DESIGN AND METHODS C57BL/6J mice were randomly divided into seven groups, normal chow (NC), HFHS, Orlistat, SCE, and low-, medium-, high- doses of SCF for 12 weeks.
34561124	5	28	theme	high-	837:841	arg1	doses					843:847	high- doses	837:847	high- doses of SCF for 12 weeks	837:867	STUDY DESIGN AND METHODS C57BL/6J mice were randomly divided into seven groups, normal chow (NC), HFHS, Orlistat, SCE, and low-, medium-, high- doses of SCF for 12 weeks.
34561124	15	29	theme	LPS-TLR4/NF-κB	2295:2308	arg1	pathway					2320:2326	the LPS-TLR4/NF-κB signaling pathway	2291:2326	the LPS-TLR4/NF-κB signaling pathway	2291:2326	Furthermore, the abundance of gut barrier protective species Akkermansia spp was increased to alleviate inflammatory response, inhibiting the LPS-TLR4/NF-κB signaling pathway.
34561124	4	30	theme	-induced	665:672	arg1	mice					680:683	high-fat/high-sucrose (HFHS)-induced obese mice	637:683	high-fat/high-sucrose (HFHS)-induced obese mice	637:683	PURPOSE To investigate the role of SCF in providing the anti-inflammatory response and the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks.
34561124	3	31	from	mechanisms	402:411	arg1	treatment					487:495	Smilax china L. flavonoid (SCF) treatment	455:495	Smilax china L. flavonoid (SCF) treatment	455:495	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	3	31	from	mechanisms	402:411	arg1	mice					447:450	mice	447:450	mice on Smilax china L. flavonoid (SCF) treatment	447:495	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	7	32	theme	markers	1064:1070	arg1	levels					1033:1038	The gene and protein expression levels	1001:1038	The gene and protein expression levels of inflammation-related markers	1001:1070	The gene and protein expression levels of inflammation-related markers were measured by qRT-PCR and Western blot.
34561124	1	33	theme	traditional	135:145	arg1	Smilax					116:121	BACKGROUND Smilax china L.	105:130	BACKGROUND Smilax china L.	105:130	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34561124	1	33	theme	traditional	135:145	arg1	herb					155:158	a traditional Chinese herb	133:158	a traditional Chinese herb	133:158	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34561124	13	34	theme	Streptococcaceae	1861:1876	arg1	abundance					1848:1856	The relative abundance	1835:1856	The relative abundance of Streptococcaceae, Faecalibaculum, and endotoxin-producing Desulfovibrionaceae	1835:1937	The relative abundance of Streptococcaceae, Faecalibaculum, and endotoxin-producing Desulfovibrionaceae were significantly decreased on SCF supplements.
34561124	0	35	theme	gut-liver	81:89	arg1	axis					91:94	the gut-liver axis	77:94	the gut-liver axis in mice	77:102	Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice.
34561124	6	36	theme	liver	887:891	arg1	weight					893:898	liver weight	887:898	liver weight	887:898	The body weight, liver weight, serum concentrations of lipopolysaccharide (LPS), and inflammatory cytokines in mice were assessed.
34561124	5	37	theme	DESIGN	705:710	arg1	mice					733:736	STUDY DESIGN AND METHODS C57BL/6J mice	699:736	STUDY DESIGN AND METHODS C57BL/6J mice	699:736	STUDY DESIGN AND METHODS C57BL/6J mice were randomly divided into seven groups, normal chow (NC), HFHS, Orlistat, SCE, and low-, medium-, high- doses of SCF for 12 weeks.
34561124	12	38	theme	SCF	1696:1698	arg1	treatment					1700:1708	SCF treatment	1696:1708	SCF treatment	1696:1708	Moreover, SCF treatment ameliorated HFHS-induced gut dysbiosis, as revealed by an increased intestinal barrier protective species (Akkermansia spp).
34561124	9	39	theme	increased	1379:1387	arg1	IL-10					1389:1393	increased IL-10	1379:1393	increased IL-10	1379:1393	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	1	40	dep	Smilax	116:121	arg1	L.					129:130	BACKGROUND Smilax china L.	105:130	BACKGROUND Smilax china L.	105:130	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34561124	14	41	theme	bacteria	2137:2144	arg1	group					2146:2150	the LPS-producing bacteria and pro-inflammatory bacteria group	2089:2150	the LPS-producing bacteria and pro-inflammatory bacteria group	2089:2150	CONCLUSION The results showed that SCF effectively inhibits HFHS-induced inflammation by suppressing the LPS-producing bacteria and pro-inflammatory bacteria group.
34561124	3	42	theme	microbiota	433:442	arg1	mechanisms					402:411	the underlying anti-inflammatory mechanisms	369:411	the underlying anti-inflammatory mechanisms	369:411	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	3	42	theme	microbiota	433:442	arg1	role					421:424	the role	417:424	the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment	417:495	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	5	43	theme	METHODS	716:722	arg1	mice					733:736	STUDY DESIGN AND METHODS C57BL/6J mice	699:736	STUDY DESIGN AND METHODS C57BL/6J mice	699:736	STUDY DESIGN AND METHODS C57BL/6J mice were randomly divided into seven groups, normal chow (NC), HFHS, Orlistat, SCE, and low-, medium-, high- doses of SCF for 12 weeks.
34561124	9	44	theme	RESULTS	1209:1215	arg1	supplement					1221:1230	RESULTS SCF supplement	1209:1230	RESULTS SCF supplement	1209:1230	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	15	45	theme	signaling	2310:2318	arg1	pathway					2320:2326	the LPS-TLR4/NF-κB signaling pathway	2291:2326	the LPS-TLR4/NF-κB signaling pathway	2291:2326	Furthermore, the abundance of gut barrier protective species Akkermansia spp was increased to alleviate inflammatory response, inhibiting the LPS-TLR4/NF-κB signaling pathway.
34561124	6	46	theme	inflammatory	955:966	arg1	cytokines					968:976	inflammatory cytokines	955:976	inflammatory cytokines in mice	955:984	The body weight, liver weight, serum concentrations of lipopolysaccharide (LPS), and inflammatory cytokines in mice were assessed.
34561124	3	47	theme	underlying	373:382	arg1	mechanisms					402:411	the underlying anti-inflammatory mechanisms	369:411	the underlying anti-inflammatory mechanisms	369:411	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	6	48	from	weight	893:898	arg1	mice					981:984	mice	981:984	mice	981:984	The body weight, liver weight, serum concentrations of lipopolysaccharide (LPS), and inflammatory cytokines in mice were assessed.
34561124	5	49	theme	normal	779:784	arg1	NC					792:793	NC	792:793	NC	792:793	STUDY DESIGN AND METHODS C57BL/6J mice were randomly divided into seven groups, normal chow (NC), HFHS, Orlistat, SCE, and low-, medium-, high- doses of SCF for 12 weeks.
34561124	5	49	theme	normal	779:784	arg1	groups					771:776	seven groups	765:776	seven groups	765:776	STUDY DESIGN AND METHODS C57BL/6J mice were randomly divided into seven groups, normal chow (NC), HFHS, Orlistat, SCE, and low-, medium-, high- doses of SCF for 12 weeks.
34561124	5	49	theme	normal	779:784	arg1	chow					786:789	normal chow	779:789	normal chow (NC)	779:794	STUDY DESIGN AND METHODS C57BL/6J mice were randomly divided into seven groups, normal chow (NC), HFHS, Orlistat, SCE, and low-, medium-, high- doses of SCF for 12 weeks.
34561124	5	50	theme	SCF	852:854	arg1	low-					822:825	low-	822:825	low-	822:825	STUDY DESIGN AND METHODS C57BL/6J mice were randomly divided into seven groups, normal chow (NC), HFHS, Orlistat, SCE, and low-, medium-, high- doses of SCF for 12 weeks.
34561124	5	50	theme	SCF	852:854	arg1	doses					843:847	high- doses	837:847	high- doses of SCF for 12 weeks	837:867	STUDY DESIGN AND METHODS C57BL/6J mice were randomly divided into seven groups, normal chow (NC), HFHS, Orlistat, SCE, and low-, medium-, high- doses of SCF for 12 weeks.
34561124	4	51	from	role	547:550	arg1	mice					680:683	high-fat/high-sucrose (HFHS)-induced obese mice	637:683	high-fat/high-sucrose (HFHS)-induced obese mice	637:683	PURPOSE To investigate the role of SCF in providing the anti-inflammatory response and the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks.
34561124	14	52	theme	LPS-producing	2093:2105	arg1	bacteria					2107:2114	LPS-producing bacteria	2093:2114	LPS-producing bacteria	2093:2114	CONCLUSION The results showed that SCF effectively inhibits HFHS-induced inflammation by suppressing the LPS-producing bacteria and pro-inflammatory bacteria group.
34561124	3	53	theme	Smilax	455:460	arg1	SCF					482:484	SCF	482:484	SCF	482:484	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	3	53	theme	Smilax	455:460	arg1	flavonoid					471:479	Smilax china L. flavonoid	455:479	Smilax china L. flavonoid (SCF) treatment	455:495	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	0	54	theme	L.	13:14	arg1	flavonoid					16:24	Smilax china L. flavonoid	0:24	Smilax china L. flavonoid	0:24	Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice.
34561124	9	55	theme	body	1240:1243	arg1	gain					1252:1255	body weight gain	1240:1255	body weight gain	1240:1255	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	1	56	theme	BACKGROUND	105:114	arg1	Smilax					116:121	BACKGROUND Smilax china L.	105:130	BACKGROUND Smilax china L.	105:130	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34561124	1	56	theme	BACKGROUND	105:114	arg1	herb					155:158	a traditional Chinese herb	133:158	a traditional Chinese herb	133:158	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34561124	14	57	dep	CONCLUSION	1988:1997	arg1	showed					2011:2016	showed	2011:2016	showed that SCF effectively inhibits HFHS-induced inflammation by suppressing the LPS-producing bacteria and pro-inflammatory bacteria group	2011:2150	CONCLUSION The results showed that SCF effectively inhibits HFHS-induced inflammation by suppressing the LPS-producing bacteria and pro-inflammatory bacteria group.
34561124	16	58	theme	inflammatory	2388:2399	arg1	diseases					2401:2408	diet-induced inflammatory diseases	2375:2408	diet-induced inflammatory diseases	2375:2408	Thus, SCF may be a promising prophylactic for diet-induced inflammatory diseases through the gut-liver axis in mice.
34561124	6	59	theme	lipopolysaccharide	925:942	arg1	weight					879:884	The body weight	870:884	The body weight	870:884	The body weight, liver weight, serum concentrations of lipopolysaccharide (LPS), and inflammatory cytokines in mice were assessed.
34561124	6	59	theme	lipopolysaccharide	925:942	arg1	weight					893:898	liver weight	887:898	liver weight	887:898	The body weight, liver weight, serum concentrations of lipopolysaccharide (LPS), and inflammatory cytokines in mice were assessed.
34561124	6	59	theme	lipopolysaccharide	925:942	arg1	concentrations					907:920	serum concentrations	901:920	serum concentrations of lipopolysaccharide (LPS)	901:948	The body weight, liver weight, serum concentrations of lipopolysaccharide (LPS), and inflammatory cytokines in mice were assessed.
34561124	6	59	theme	lipopolysaccharide	925:942	arg1	cytokines					968:976	inflammatory cytokines	955:976	inflammatory cytokines in mice	955:984	The body weight, liver weight, serum concentrations of lipopolysaccharide (LPS), and inflammatory cytokines in mice were assessed.
34561124	11	60	theme	protein	1621:1627	arg1	levels					1640:1645	the TLR4, p-IκBα, NF-κB, and p65 protein expression levels	1588:1645	the TLR4, p-IκBα, NF-κB, and p65 protein expression levels	1588:1645	In addition, the TLR4, p-IκBα, NF-κB, and p65 protein expression levels were reduced after the SCF supplement.
34561124	7	61	theme	expression	1022:1031	arg1	levels					1033:1038	The gene and protein expression levels	1001:1038	The gene and protein expression levels of inflammation-related markers	1001:1070	The gene and protein expression levels of inflammation-related markers were measured by qRT-PCR and Western blot.
34561124	9	62	theme	adipose	1258:1264	arg1	tissue					1266:1271	adipose tissue	1258:1271	adipose tissue	1258:1271	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	13	63	theme	relative	1839:1846	arg1	abundance					1848:1856	The relative abundance	1835:1856	The relative abundance of Streptococcaceae, Faecalibaculum, and endotoxin-producing Desulfovibrionaceae	1835:1937	The relative abundance of Streptococcaceae, Faecalibaculum, and endotoxin-producing Desulfovibrionaceae were significantly decreased on SCF supplements.
34561124	2	64	theme	several	323:329	arg1	models					352:357	several in vivo experimental models	323:357	several in vivo experimental models	323:357	The anti-inflammatory activity of the plant extract has been reported in several in vivo experimental models.
34561124	15	65	theme	gut	2183:2185	arg1	spp					2226:2228	gut barrier protective species Akkermansia spp	2183:2228	gut barrier protective species Akkermansia spp	2183:2228	Furthermore, the abundance of gut barrier protective species Akkermansia spp was increased to alleviate inflammatory response, inhibiting the LPS-TLR4/NF-κB signaling pathway.
34561124	16	66	theme	gut-liver	2422:2430	arg1	axis					2432:2435	the gut-liver axis	2418:2435	the gut-liver axis in mice	2418:2443	Thus, SCF may be a promising prophylactic for diet-induced inflammatory diseases through the gut-liver axis in mice.
34561124	4	67	theme	anti-inflammatory	576:592	arg1	response					594:601	the anti-inflammatory response	572:601	the anti-inflammatory response	572:601	PURPOSE To investigate the role of SCF in providing the anti-inflammatory response and the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks.
34561124	12	68	theme	protective	1797:1806	arg1	species					1808:1814	an increased intestinal barrier protective species	1765:1814	an increased intestinal barrier protective species (Akkermansia spp)	1765:1832	Moreover, SCF treatment ameliorated HFHS-induced gut dysbiosis, as revealed by an increased intestinal barrier protective species (Akkermansia spp).
34561124	12	68	theme	protective	1797:1806	arg1	spp					1829:1831	spp	1829:1831	spp	1829:1831	Moreover, SCF treatment ameliorated HFHS-induced gut dysbiosis, as revealed by an increased intestinal barrier protective species (Akkermansia spp).
34561124	14	69	theme	HFHS-induced	2048:2059	arg1	inflammation					2061:2072	HFHS-induced inflammation	2048:2072	HFHS-induced inflammation	2048:2072	CONCLUSION The results showed that SCF effectively inhibits HFHS-induced inflammation by suppressing the LPS-producing bacteria and pro-inflammatory bacteria group.
34561124	7	70	theme	gene	1005:1008	arg1	levels					1033:1038	The gene and protein expression levels	1001:1038	The gene and protein expression levels of inflammation-related markers	1001:1070	The gene and protein expression levels of inflammation-related markers were measured by qRT-PCR and Western blot.
34561124	10	71	theme	IL-10	1532:1536	arg1	expression					1500:1509	the expression	1496:1509	the expression of AMPK, PPAR-γ, and IL-10 in mice's liver and adipose tissues	1496:1572	SCF significantly reduced the mRNA expression levels of TNF-α, IL-6, and increased the expression of AMPK, PPAR-γ, and IL-10 in mice's liver and adipose tissues.
34561124	9	72	theme	attenuated	1292:1301	arg1	levels					1309:1314	attenuated serum levels	1292:1314	attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10	1292:1393	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	4	73	theme	SCF	555:557	arg1	role					611:614	the role	607:614	the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks	607:696	PURPOSE To investigate the role of SCF in providing the anti-inflammatory response and the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks.
34561124	4	73	theme	SCF	555:557	arg1	role					547:550	the role	543:550	the role of SCF in providing the anti-inflammatory response	543:601	PURPOSE To investigate the role of SCF in providing the anti-inflammatory response and the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks.
34561124	3	74	from	treatment	487:495	arg1	mechanisms					402:411	the underlying anti-inflammatory mechanisms	369:411	the underlying anti-inflammatory mechanisms	369:411	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	3	74	from	treatment	487:495	arg1	role					421:424	the role	417:424	the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment	417:495	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	2	75	theme	plant	288:292	arg1	extract					294:300	the plant extract	284:300	the plant extract	284:300	The anti-inflammatory activity of the plant extract has been reported in several in vivo experimental models.
34561124	13	76	theme	SCF	1971:1973	arg1	supplements					1975:1985	SCF supplements	1971:1985	SCF supplements	1971:1985	The relative abundance of Streptococcaceae, Faecalibaculum, and endotoxin-producing Desulfovibrionaceae were significantly decreased on SCF supplements.
34561124	11	77	theme	p65	1617:1619	arg1	levels					1640:1645	the TLR4, p-IκBα, NF-κB, and p65 protein expression levels	1588:1645	the TLR4, p-IκBα, NF-κB, and p65 protein expression levels	1588:1645	In addition, the TLR4, p-IκBα, NF-κB, and p65 protein expression levels were reduced after the SCF supplement.
34561124	9	78	theme	LPS	1370:1372	arg1	indexes					1283:1289	liver indexes	1277:1289	liver indexes	1277:1289	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	78	theme	LPS	1370:1372	arg1	adiponectin					1400:1410	adiponectin	1400:1410	adiponectin	1400:1410	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	78	theme	LPS	1370:1372	arg1	levels					1309:1314	attenuated serum levels	1292:1314	attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10	1292:1393	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	78	theme	LPS	1370:1372	arg1	gain					1252:1255	body weight gain	1240:1255	body weight gain	1240:1255	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	78	theme	LPS	1370:1372	arg1	tissue					1266:1271	adipose tissue	1258:1271	adipose tissue	1258:1271	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	79	theme	tumor	1319:1323	arg1	factor					1334:1339	tumor necrosis factor (TNF)-α	1319:1347	tumor necrosis factor (TNF)-α	1319:1347	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	79	theme	tumor	1319:1323	arg1	TNF					1342:1344	TNF	1342:1344	TNF	1342:1344	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	12	80	theme	intestinal	1778:1787	arg1	barrier					1789:1795	an increased intestinal barrier	1765:1795	an increased intestinal barrier protective species (Akkermansia spp)	1765:1832	Moreover, SCF treatment ameliorated HFHS-induced gut dysbiosis, as revealed by an increased intestinal barrier protective species (Akkermansia spp).
34561124	10	81	theme	mRNA	1443:1446	arg1	levels					1459:1464	the mRNA expression levels	1439:1464	the mRNA expression levels of TNF-α, IL-6	1439:1479	SCF significantly reduced the mRNA expression levels of TNF-α, IL-6, and increased the expression of AMPK, PPAR-γ, and IL-10 in mice's liver and adipose tissues.
34561124	9	82	theme	factor	1334:1339	arg1	indexes					1283:1289	liver indexes	1277:1289	liver indexes	1277:1289	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	82	theme	factor	1334:1339	arg1	adiponectin					1400:1410	adiponectin	1400:1410	adiponectin	1400:1410	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	82	theme	factor	1334:1339	arg1	levels					1309:1314	attenuated serum levels	1292:1314	attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10	1292:1393	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	82	theme	factor	1334:1339	arg1	gain					1252:1255	body weight gain	1240:1255	body weight gain	1240:1255	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	82	theme	factor	1334:1339	arg1	tissue					1266:1271	adipose tissue	1258:1271	adipose tissue	1258:1271	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	6	83	theme	body	874:877	arg1	weight					879:884	The body weight	870:884	The body weight	870:884	The body weight, liver weight, serum concentrations of lipopolysaccharide (LPS), and inflammatory cytokines in mice were assessed.
34561124	0	84	from	axis	91:94	arg1	mice					99:102	mice	99:102	mice	99:102	Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice.
34561124	8	85	theme	microbiota	1147:1156	arg1	composition					1128:1138	the composition	1124:1138	the composition of gut microbiota	1124:1156	Finally, the composition of gut microbiota was detected by analyzing 16S rDNA gene sequences.
34561124	10	86	theme	TNF-α	1469:1473	arg1	levels					1459:1464	the mRNA expression levels	1439:1464	the mRNA expression levels of TNF-α, IL-6	1439:1479	SCF significantly reduced the mRNA expression levels of TNF-α, IL-6, and increased the expression of AMPK, PPAR-γ, and IL-10 in mice's liver and adipose tissues.
34561124	10	87	theme	PPAR-γ	1520:1525	arg1	expression					1500:1509	the expression	1496:1509	the expression of AMPK, PPAR-γ, and IL-10 in mice's liver and adipose tissues	1496:1572	SCF significantly reduced the mRNA expression levels of TNF-α, IL-6, and increased the expression of AMPK, PPAR-γ, and IL-10 in mice's liver and adipose tissues.
34561124	13	88	theme	Desulfovibrionaceae	1919:1937	arg1	abundance					1848:1856	The relative abundance	1835:1856	The relative abundance of Streptococcaceae, Faecalibaculum, and endotoxin-producing Desulfovibrionaceae	1835:1937	The relative abundance of Streptococcaceae, Faecalibaculum, and endotoxin-producing Desulfovibrionaceae were significantly decreased on SCF supplements.
34561124	4	89	from	role	611:614	arg1	mice					680:683	high-fat/high-sucrose (HFHS)-induced obese mice	637:683	high-fat/high-sucrose (HFHS)-induced obese mice	637:683	PURPOSE To investigate the role of SCF in providing the anti-inflammatory response and the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks.
34561124	1	90	theme	various	184:190	arg1	disorders					205:213	various inflammatory disorders	184:213	various inflammatory disorders	184:213	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34561124	4	91	theme	gut	619:621	arg1	microbiota					623:632	gut microbiota	619:632	gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice	619:683	PURPOSE To investigate the role of SCF in providing the anti-inflammatory response and the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks.
34561124	9	92	theme	interleukin	1350:1360	arg1	IL					1363:1364	interleukin (IL)-6	1350:1367	interleukin (IL)-6	1350:1367	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	12	93	theme	gut	1735:1737	arg1	dysbiosis					1739:1747	HFHS-induced gut dysbiosis	1722:1747	HFHS-induced gut dysbiosis	1722:1747	Moreover, SCF treatment ameliorated HFHS-induced gut dysbiosis, as revealed by an increased intestinal barrier protective species (Akkermansia spp).
34561124	13	94	theme	Faecalibaculum	1879:1892	arg1	abundance					1848:1856	The relative abundance	1835:1856	The relative abundance of Streptococcaceae, Faecalibaculum, and endotoxin-producing Desulfovibrionaceae	1835:1937	The relative abundance of Streptococcaceae, Faecalibaculum, and endotoxin-producing Desulfovibrionaceae were significantly decreased on SCF supplements.
34561124	2	95	theme	anti-inflammatory	254:270	arg1	activity					272:279	The anti-inflammatory activity	250:279	The anti-inflammatory activity of the plant extract	250:300	The anti-inflammatory activity of the plant extract has been reported in several in vivo experimental models.
34561124	9	96	theme	IL	1363:1364	arg1	indexes					1283:1289	liver indexes	1277:1289	liver indexes	1277:1289	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	96	theme	IL	1363:1364	arg1	adiponectin					1400:1410	adiponectin	1400:1410	adiponectin	1400:1410	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	96	theme	IL	1363:1364	arg1	levels					1309:1314	attenuated serum levels	1292:1314	attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10	1292:1393	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	96	theme	IL	1363:1364	arg1	gain					1252:1255	body weight gain	1240:1255	body weight gain	1240:1255	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	96	theme	IL	1363:1364	arg1	tissue					1266:1271	adipose tissue	1258:1271	adipose tissue	1258:1271	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	8	97	theme	rDNA	1188:1191	arg1	sequences					1198:1206	16S rDNA gene sequences	1184:1206	16S rDNA gene sequences	1184:1206	Finally, the composition of gut microbiota was detected by analyzing 16S rDNA gene sequences.
34561124	3	98	theme	L.	468:469	arg1	SCF					482:484	SCF	482:484	SCF	482:484	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	3	98	theme	L.	468:469	arg1	flavonoid					471:479	Smilax china L. flavonoid	455:479	Smilax china L. flavonoid (SCF) treatment	455:495	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	5	99	theme	C57BL/6J	724:731	arg1	mice					733:736	STUDY DESIGN AND METHODS C57BL/6J mice	699:736	STUDY DESIGN AND METHODS C57BL/6J mice	699:736	STUDY DESIGN AND METHODS C57BL/6J mice were randomly divided into seven groups, normal chow (NC), HFHS, Orlistat, SCE, and low-, medium-, high- doses of SCF for 12 weeks.
34561124	15	100	theme	species	2206:2212	arg1	spp					2226:2228	gut barrier protective species Akkermansia spp	2183:2228	gut barrier protective species Akkermansia spp	2183:2228	Furthermore, the abundance of gut barrier protective species Akkermansia spp was increased to alleviate inflammatory response, inhibiting the LPS-TLR4/NF-κB signaling pathway.
34561124	6	101	theme	serum	901:905	arg1	concentrations					907:920	serum concentrations	901:920	serum concentrations of lipopolysaccharide (LPS)	901:948	The body weight, liver weight, serum concentrations of lipopolysaccharide (LPS), and inflammatory cytokines in mice were assessed.
34561124	7	102	theme	Western	1101:1107	arg1	blot					1109:1112	Western blot	1101:1112	Western blot	1101:1112	The gene and protein expression levels of inflammation-related markers were measured by qRT-PCR and Western blot.
34561124	1	103	theme	Chinese	147:153	arg1	Smilax					116:121	BACKGROUND Smilax china L.	105:130	BACKGROUND Smilax china L.	105:130	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34561124	1	103	theme	Chinese	147:153	arg1	herb					155:158	a traditional Chinese herb	133:158	a traditional Chinese herb	133:158	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34561124	4	104	theme	obese	674:678	arg1	mice					680:683	high-fat/high-sucrose (HFHS)-induced obese mice	637:683	high-fat/high-sucrose (HFHS)-induced obese mice	637:683	PURPOSE To investigate the role of SCF in providing the anti-inflammatory response and the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks.
34561124	5	105	theme	STUDY	699:703	arg1	DESIGN					705:710	STUDY DESIGN	699:710	STUDY DESIGN	699:710	STUDY DESIGN AND METHODS C57BL/6J mice were randomly divided into seven groups, normal chow (NC), HFHS, Orlistat, SCE, and low-, medium-, high- doses of SCF for 12 weeks.
34561124	3	106	from	role	421:424	arg1	treatment					487:495	Smilax china L. flavonoid (SCF) treatment	455:495	Smilax china L. flavonoid (SCF) treatment	455:495	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	3	106	from	role	421:424	arg1	mice					447:450	mice	447:450	mice on Smilax china L. flavonoid (SCF) treatment	447:495	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	6	107	from	concentrations	907:920	arg1	mice					981:984	mice	981:984	mice	981:984	The body weight, liver weight, serum concentrations of lipopolysaccharide (LPS), and inflammatory cytokines in mice were assessed.
34561124	10	108	theme	AMPK	1514:1517	arg1	expression					1500:1509	the expression	1496:1509	the expression of AMPK, PPAR-γ, and IL-10 in mice's liver and adipose tissues	1496:1572	SCF significantly reduced the mRNA expression levels of TNF-α, IL-6, and increased the expression of AMPK, PPAR-γ, and IL-10 in mice's liver and adipose tissues.
34561124	9	109	theme	IL-10	1389:1393	arg1	indexes					1283:1289	liver indexes	1277:1289	liver indexes	1277:1289	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	109	theme	IL-10	1389:1393	arg1	adiponectin					1400:1410	adiponectin	1400:1410	adiponectin	1400:1410	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	109	theme	IL-10	1389:1393	arg1	levels					1309:1314	attenuated serum levels	1292:1314	attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10	1292:1393	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	109	theme	IL-10	1389:1393	arg1	gain					1252:1255	body weight gain	1240:1255	body weight gain	1240:1255	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	9	109	theme	IL-10	1389:1393	arg1	tissue					1266:1271	adipose tissue	1258:1271	adipose tissue	1258:1271	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	6	110	from	weight	879:884	arg1	mice					981:984	mice	981:984	mice	981:984	The body weight, liver weight, serum concentrations of lipopolysaccharide (LPS), and inflammatory cytokines in mice were assessed.
34561124	15	111	theme	barrier	2187:2193	arg1	spp					2226:2228	gut barrier protective species Akkermansia spp	2183:2228	gut barrier protective species Akkermansia spp	2183:2228	Furthermore, the abundance of gut barrier protective species Akkermansia spp was increased to alleviate inflammatory response, inhibiting the LPS-TLR4/NF-κB signaling pathway.
34561124	14	112	theme	pro-inflammatory	2120:2135	arg1	bacteria					2137:2144	pro-inflammatory bacteria	2120:2144	pro-inflammatory bacteria	2120:2144	CONCLUSION The results showed that SCF effectively inhibits HFHS-induced inflammation by suppressing the LPS-producing bacteria and pro-inflammatory bacteria group.
34561124	0	113	theme	china	7:11	arg1	flavonoid					16:24	Smilax china L. flavonoid	0:24	Smilax china L. flavonoid	0:24	Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice.
34561124	9	114	theme	SCF	1217:1219	arg1	supplement					1221:1230	RESULTS SCF supplement	1209:1230	RESULTS SCF supplement	1209:1230	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	3	115	theme	anti-inflammatory	384:400	arg1	mechanisms					402:411	the underlying anti-inflammatory mechanisms	369:411	the underlying anti-inflammatory mechanisms	369:411	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	14	116	theme	bacteria	2107:2114	arg1	group					2146:2150	the LPS-producing bacteria and pro-inflammatory bacteria group	2089:2150	the LPS-producing bacteria and pro-inflammatory bacteria group	2089:2150	CONCLUSION The results showed that SCF effectively inhibits HFHS-induced inflammation by suppressing the LPS-producing bacteria and pro-inflammatory bacteria group.
34561124	3	117	theme	gut	429:431	arg1	microbiota					433:442	gut microbiota	429:442	gut microbiota	429:442	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	7	118	theme	inflammation-related	1043:1062	arg1	markers					1064:1070	inflammation-related markers	1043:1070	inflammation-related markers	1043:1070	The gene and protein expression levels of inflammation-related markers were measured by qRT-PCR and Western blot.
34561124	2	119	dep	in	331:332	arg1	vivo					334:337	vivo	334:337	vivo	334:337	The anti-inflammatory activity of the plant extract has been reported in several in vivo experimental models.
34561124	3	120	theme	china	462:466	arg1	SCF					482:484	SCF	482:484	SCF	482:484	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	3	120	theme	china	462:466	arg1	flavonoid					471:479	Smilax china L. flavonoid	455:479	Smilax china L. flavonoid (SCF) treatment	455:495	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	0	121	theme	HFHS-induced	37:48	arg1	inflammation					50:61	HFHS-induced inflammation	37:61	HFHS-induced inflammation	37:61	Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice.
34561124	9	122	theme	weight	1245:1250	arg1	gain					1252:1255	body weight gain	1240:1255	body weight gain	1240:1255	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	3	123	from	mice	447:450	arg1	treatment					487:495	Smilax china L. flavonoid (SCF) treatment	455:495	Smilax china L. flavonoid (SCF) treatment	455:495	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	7	124	theme	protein	1014:1020	arg1	levels					1033:1038	The gene and protein expression levels	1001:1038	The gene and protein expression levels of inflammation-related markers	1001:1070	The gene and protein expression levels of inflammation-related markers were measured by qRT-PCR and Western blot.
34561124	16	125	theme	diet-induced	2375:2386	arg1	diseases					2401:2408	diet-induced inflammatory diseases	2375:2408	diet-induced inflammatory diseases	2375:2408	Thus, SCF may be a promising prophylactic for diet-induced inflammatory diseases through the gut-liver axis in mice.
34561124	15	126	theme	inflammatory	2257:2268	arg1	response					2270:2277	inflammatory response	2257:2277	inflammatory response	2257:2277	Furthermore, the abundance of gut barrier protective species Akkermansia spp was increased to alleviate inflammatory response, inhibiting the LPS-TLR4/NF-κB signaling pathway.
34561124	2	127	theme	in	331:332	arg1	models					352:357	several in vivo experimental models	323:357	several in vivo experimental models	323:357	The anti-inflammatory activity of the plant extract has been reported in several in vivo experimental models.
34561124	11	128	theme	expression	1629:1638	arg1	levels					1640:1645	the TLR4, p-IκBα, NF-κB, and p65 protein expression levels	1588:1645	the TLR4, p-IκBα, NF-κB, and p65 protein expression levels	1588:1645	In addition, the TLR4, p-IκBα, NF-κB, and p65 protein expression levels were reduced after the SCF supplement.
34561124	3	129	theme	flavonoid	471:479	arg1	treatment					487:495	Smilax china L. flavonoid (SCF) treatment	455:495	Smilax china L. flavonoid (SCF) treatment	455:495	However, the underlying anti-inflammatory mechanisms and the role of gut microbiota in mice on Smilax china L. flavonoid (SCF) treatment are poorly understand.
34561124	9	130	theme	liver	1277:1281	arg1	indexes					1283:1289	liver indexes	1277:1289	liver indexes	1277:1289	RESULTS SCF supplement reduced body weight gain, adipose tissue and liver indexes, attenuated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, LPS, and increased IL-10, and adiponectin.
34561124	4	131	from	mice	680:683	arg1	role					611:614	the role	607:614	the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks	607:696	PURPOSE To investigate the role of SCF in providing the anti-inflammatory response and the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks.
34561124	4	131	from	mice	680:683	arg1	role					547:550	the role	543:550	the role of SCF in providing the anti-inflammatory response	543:601	PURPOSE To investigate the role of SCF in providing the anti-inflammatory response and the role of gut microbiota in high-fat/high-sucrose (HFHS)-induced obese mice for 12 weeks.
34561124	1	132	theme	pelvic	229:234	arg1	inflammation					236:247	pelvic inflammation	229:247	pelvic inflammation	229:247	BACKGROUND Smilax china L., a traditional Chinese herb, has been used to treat various inflammatory disorders, particularly pelvic inflammation.
34774596	1	0	theme	functional	168:177	arg1	film					202:205	A functional carrageenan/agar-based film	166:205	A functional carrageenan/agar-based film	166:205	A functional carrageenan/agar-based film was prepared by combining tea tree oil Pickering emulsion (PET) and zinc sulfide nanoparticles (ZnSNP).
34774596	7	1	theme	functional	1064:1073	arg1	properties					1075:1084	enhanced physical and functional properties	1042:1084	enhanced physical and functional properties	1042:1084	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	6	2	theme	composite	908:916	arg1	membrane					918:925	the carrageenan/agar-based composite membrane	881:925	the carrageenan/agar-based composite membrane	881:925	In addition, the carrageenan/agar-based composite membrane showed distinct antioxidant and antibacterial activity.
34774596	1	3	theme	carrageenan/agar-based	179:200	arg1	film					202:205	A functional carrageenan/agar-based film	166:205	A functional carrageenan/agar-based film	166:205	A functional carrageenan/agar-based film was prepared by combining tea tree oil Pickering emulsion (PET) and zinc sulfide nanoparticles (ZnSNP).
34774596	0	4	theme	tree	112:115	arg1	oil					127:129	tea tree essential oil	108:129	tea tree essential oil	108:129	Carrageenan/agar-based functional film integrated with zinc sulfide nanoparticles and Pickering emulsion of tea tree essential oil for active packaging applications.
34774596	6	5	theme	carrageenan/agar-based	885:906	arg1	membrane					918:925	the carrageenan/agar-based composite membrane	881:925	the carrageenan/agar-based composite membrane	881:925	In addition, the carrageenan/agar-based composite membrane showed distinct antioxidant and antibacterial activity.
34774596	7	6	theme	packaging	1123:1131	arg1	applications					1133:1144	active food packaging applications	1111:1144	active food packaging applications	1111:1144	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	1	7	theme	zinc	275:278	arg1	ZnSNP					303:307	ZnSNP	303:307	ZnSNP	303:307	A functional carrageenan/agar-based film was prepared by combining tea tree oil Pickering emulsion (PET) and zinc sulfide nanoparticles (ZnSNP).
34774596	1	7	theme	zinc	275:278	arg1	nanoparticles					288:300	zinc sulfide nanoparticles	275:300	zinc sulfide nanoparticles (ZnSNP)	275:308	A functional carrageenan/agar-based film was prepared by combining tea tree oil Pickering emulsion (PET) and zinc sulfide nanoparticles (ZnSNP).
34774596	0	8	theme	tea	108:110	arg1	oil					127:129	tea tree essential oil	108:129	tea tree essential oil	108:129	Carrageenan/agar-based functional film integrated with zinc sulfide nanoparticles and Pickering emulsion of tea tree essential oil for active packaging applications.
34774596	1	9	theme	sulfide	280:286	arg1	ZnSNP					303:307	ZnSNP	303:307	ZnSNP	303:307	A functional carrageenan/agar-based film was prepared by combining tea tree oil Pickering emulsion (PET) and zinc sulfide nanoparticles (ZnSNP).
34774596	1	9	theme	sulfide	280:286	arg1	nanoparticles					288:300	zinc sulfide nanoparticles	275:300	zinc sulfide nanoparticles (ZnSNP)	275:308	A functional carrageenan/agar-based film was prepared by combining tea tree oil Pickering emulsion (PET) and zinc sulfide nanoparticles (ZnSNP).
34774596	0	10	theme	oil	127:129	arg1	emulsion					96:103	Pickering emulsion	86:103	Pickering emulsion of tea tree essential oil for active packaging applications	86:163	Carrageenan/agar-based functional film integrated with zinc sulfide nanoparticles and Pickering emulsion of tea tree essential oil for active packaging applications.
34774596	0	10	theme	oil	127:129	arg1	nanoparticles					68:80	zinc sulfide nanoparticles	55:80	zinc sulfide nanoparticles	55:80	Carrageenan/agar-based functional film integrated with zinc sulfide nanoparticles and Pickering emulsion of tea tree essential oil for active packaging applications.
34774596	7	11	theme	active	1111:1116	arg1	applications					1133:1144	active food packaging applications	1111:1144	active food packaging applications	1111:1144	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	3	12	theme	compatible	477:486	arg1	films					488:492	compatible films	477:492	compatible films	477:492	PET and ZnSNPs were uniformly dispersed in the binary polymer matrix and formed compatible films.
34774596	3	13	theme	binary	444:449	arg1	matrix					459:464	the binary polymer matrix	440:464	the binary polymer matrix	440:464	PET and ZnSNPs were uniformly dispersed in the binary polymer matrix and formed compatible films.
34774596	0	14	theme	essential	117:125	arg1	oil					127:129	tea tree essential oil	108:129	tea tree essential oil	108:129	Carrageenan/agar-based functional film integrated with zinc sulfide nanoparticles and Pickering emulsion of tea tree essential oil for active packaging applications.
34774596	7	15	theme	food	1118:1121	arg1	applications					1133:1144	active food packaging applications	1111:1144	active food packaging applications	1111:1144	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	7	16	with	PET	997:999	arg1	properties					1075:1084	enhanced physical and functional properties	1042:1084	enhanced physical and functional properties	1042:1084	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	3	17	theme	polymer	451:457	arg1	matrix					459:464	the binary polymer matrix	440:464	the binary polymer matrix	440:464	PET and ZnSNPs were uniformly dispersed in the binary polymer matrix and formed compatible films.
34774596	0	18	theme	functional	23:32	arg1	film					34:37	Carrageenan/agar-based functional film	0:37	Carrageenan/agar-based functional film	0:37	Carrageenan/agar-based functional film integrated with zinc sulfide nanoparticles and Pickering emulsion of tea tree essential oil for active packaging applications.
34774596	5	19	theme	film	862:865	arg1	stability					845:853	thermal stability	837:853	thermal stability of the film	837:865	The addition of ZnSNP and PET, alone or in combination, slightly improved the water vapor barrier, water resistance, and thermal stability of the film.
34774596	5	19	theme	film	862:865	arg1	barrier					806:812	the water vapor barrier	790:812	the water vapor barrier	790:812	The addition of ZnSNP and PET, alone or in combination, slightly improved the water vapor barrier, water resistance, and thermal stability of the film.
34774596	5	19	theme	film	862:865	arg1	resistance					821:830	water resistance	815:830	water resistance	815:830	The addition of ZnSNP and PET, alone or in combination, slightly improved the water vapor barrier, water resistance, and thermal stability of the film.
34774596	0	20	theme	Carrageenan/agar-based	0:21	arg1	film					34:37	Carrageenan/agar-based functional film	0:37	Carrageenan/agar-based functional film	0:37	Carrageenan/agar-based functional film integrated with zinc sulfide nanoparticles and Pickering emulsion of tea tree essential oil for active packaging applications.
34774596	5	21	theme	PET	742:744	arg1	addition					720:727	The addition	716:727	The addition	716:727	The addition of ZnSNP and PET, alone or in combination, slightly improved the water vapor barrier, water resistance, and thermal stability of the film.
34774596	5	22	theme	water	815:819	arg1	resistance					821:830	water resistance	815:830	water resistance	815:830	The addition of ZnSNP and PET, alone or in combination, slightly improved the water vapor barrier, water resistance, and thermal stability of the film.
34774596	0	23	theme	active	135:140	arg1	applications					152:163	active packaging applications	135:163	active packaging applications	135:163	Carrageenan/agar-based functional film integrated with zinc sulfide nanoparticles and Pickering emulsion of tea tree essential oil for active packaging applications.
34774596	4	24	theme	PET	641:643	arg1	addition					619:626	the combined addition	606:626	the combined addition of ZnSNP and PET	606:643	The incorporation of ZnSNPs improved the mechanical strength, whereas PET slightly decreased the strength, but the combined addition of ZnSNP and PET maintained the mechanical strength with slightly improved flexibility.
34774596	1	25	theme	tea	233:235	arg1	oil					242:244	tea tree oil Pickering emulsion (PET)	233:269	tea tree oil Pickering emulsion (PET)	233:269	A functional carrageenan/agar-based film was prepared by combining tea tree oil Pickering emulsion (PET) and zinc sulfide nanoparticles (ZnSNP).
34774596	0	26	theme	zinc	55:58	arg1	nanoparticles					68:80	zinc sulfide nanoparticles	55:80	zinc sulfide nanoparticles	55:80	Carrageenan/agar-based functional film integrated with zinc sulfide nanoparticles and Pickering emulsion of tea tree essential oil for active packaging applications.
34774596	5	27	theme	ZnSNP	732:736	arg1	addition					720:727	The addition	716:727	The addition	716:727	The addition of ZnSNP and PET, alone or in combination, slightly improved the water vapor barrier, water resistance, and thermal stability of the film.
34774596	5	28	theme	thermal	837:843	arg1	stability					845:853	thermal stability	837:853	thermal stability of the film	837:865	The addition of ZnSNP and PET, alone or in combination, slightly improved the water vapor barrier, water resistance, and thermal stability of the film.
34774596	7	29	dep	ZnSNP	987:991	arg1	films					1031:1035	incorporated binary composite films	1001:1035	incorporated binary composite films	1001:1035	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	7	29	dep	ZnSNP	987:991	arg1	The					983:985	The	983:985	The	983:985	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	1	30	theme	tree	237:240	arg1	oil					242:244	tea tree oil Pickering emulsion (PET)	233:269	tea tree oil Pickering emulsion (PET)	233:269	A functional carrageenan/agar-based film was prepared by combining tea tree oil Pickering emulsion (PET) and zinc sulfide nanoparticles (ZnSNP).
34774596	6	31	theme	antibacterial	959:971	arg1	activity					973:980	antibacterial activity	959:980	antibacterial activity	959:980	In addition, the carrageenan/agar-based composite membrane showed distinct antioxidant and antibacterial activity.
34774596	0	32	theme	packaging	142:150	arg1	applications					152:163	active packaging applications	135:163	active packaging applications	135:163	Carrageenan/agar-based functional film integrated with zinc sulfide nanoparticles and Pickering emulsion of tea tree essential oil for active packaging applications.
34774596	4	33	with	strength	671:678	arg1	flexibility					703:713	slightly improved flexibility	685:713	slightly improved flexibility	685:713	The incorporation of ZnSNPs improved the mechanical strength, whereas PET slightly decreased the strength, but the combined addition of ZnSNP and PET maintained the mechanical strength with slightly improved flexibility.
34774596	7	34	with	ZnSNP	987:991	arg1	properties					1075:1084	enhanced physical and functional properties	1042:1084	enhanced physical and functional properties	1042:1084	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	5	35	theme	water	794:798	arg1	barrier					806:812	the water vapor barrier	790:812	the water vapor barrier	790:812	The addition of ZnSNP and PET, alone or in combination, slightly improved the water vapor barrier, water resistance, and thermal stability of the film.
34774596	4	36	theme	mechanical	536:545	arg1	strength					547:554	the mechanical strength	532:554	the mechanical strength	532:554	The incorporation of ZnSNPs improved the mechanical strength, whereas PET slightly decreased the strength, but the combined addition of ZnSNP and PET maintained the mechanical strength with slightly improved flexibility.
34774596	5	37	theme	vapor	800:804	arg1	barrier					806:812	the water vapor barrier	790:812	the water vapor barrier	790:812	The addition of ZnSNP and PET, alone or in combination, slightly improved the water vapor barrier, water resistance, and thermal stability of the film.
34774596	7	38	theme	enhanced	1042:1049	arg1	properties					1075:1084	enhanced physical and functional properties	1042:1084	enhanced physical and functional properties	1042:1084	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	2	39	theme	essential	345:353	arg1	oil					355:357	tea tree essential oil	336:357	tea tree essential oil stabilized with nanocellulose fibers	336:394	PET was formulated using tea tree essential oil stabilized with nanocellulose fibers.
34774596	0	40	theme	sulfide	60:66	arg1	nanoparticles					68:80	zinc sulfide nanoparticles	55:80	zinc sulfide nanoparticles	55:80	Carrageenan/agar-based functional film integrated with zinc sulfide nanoparticles and Pickering emulsion of tea tree essential oil for active packaging applications.
34774596	7	41	theme	composite	1021:1029	arg1	films					1031:1035	incorporated binary composite films	1001:1035	incorporated binary composite films	1001:1035	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	2	42	theme	tree	340:343	arg1	oil					355:357	tea tree essential oil	336:357	tea tree essential oil stabilized with nanocellulose fibers	336:394	PET was formulated using tea tree essential oil stabilized with nanocellulose fibers.
34774596	6	43	theme	distinct	934:941	arg1	antioxidant					943:953	distinct antioxidant	934:953	distinct antioxidant	934:953	In addition, the carrageenan/agar-based composite membrane showed distinct antioxidant and antibacterial activity.
34774596	7	44	theme	physical	1051:1058	arg1	properties					1075:1084	enhanced physical and functional properties	1042:1084	enhanced physical and functional properties	1042:1084	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	2	45	theme	tea	336:338	arg1	oil					355:357	tea tree essential oil	336:357	tea tree essential oil stabilized with nanocellulose fibers	336:394	PET was formulated using tea tree essential oil stabilized with nanocellulose fibers.
34774596	1	46	theme	Pickering	246:254	arg1	PET					266:268	PET	266:268	PET	266:268	A functional carrageenan/agar-based film was prepared by combining tea tree oil Pickering emulsion (PET) and zinc sulfide nanoparticles (ZnSNP).
34774596	1	46	theme	Pickering	246:254	arg1	emulsion					256:263	Pickering emulsion	246:263	tea tree oil Pickering emulsion (PET)	233:269	A functional carrageenan/agar-based film was prepared by combining tea tree oil Pickering emulsion (PET) and zinc sulfide nanoparticles (ZnSNP).
34774596	1	47	dep	oil	242:244	arg1	PET					266:268	PET	266:268	PET	266:268	A functional carrageenan/agar-based film was prepared by combining tea tree oil Pickering emulsion (PET) and zinc sulfide nanoparticles (ZnSNP).
34774596	1	47	dep	oil	242:244	arg1	emulsion					256:263	Pickering emulsion	246:263	tea tree oil Pickering emulsion (PET)	233:269	A functional carrageenan/agar-based film was prepared by combining tea tree oil Pickering emulsion (PET) and zinc sulfide nanoparticles (ZnSNP).
34774596	7	48	theme	incorporated	1001:1012	arg1	films					1031:1035	incorporated binary composite films	1001:1035	incorporated binary composite films	1001:1035	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	4	49	theme	combined	610:617	arg1	addition					619:626	the combined addition	606:626	the combined addition of ZnSNP and PET	606:643	The incorporation of ZnSNPs improved the mechanical strength, whereas PET slightly decreased the strength, but the combined addition of ZnSNP and PET maintained the mechanical strength with slightly improved flexibility.
34774596	0	50	theme	Pickering	86:94	arg1	emulsion					96:103	Pickering emulsion	86:103	Pickering emulsion of tea tree essential oil for active packaging applications	86:163	Carrageenan/agar-based functional film integrated with zinc sulfide nanoparticles and Pickering emulsion of tea tree essential oil for active packaging applications.
34774596	7	51	theme	binary	1014:1019	arg1	films					1031:1035	incorporated binary composite films	1001:1035	incorporated binary composite films	1001:1035	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	2	52	theme	nanocellulose	375:387	arg1	fibers					389:394	nanocellulose fibers	375:394	nanocellulose fibers	375:394	PET was formulated using tea tree essential oil stabilized with nanocellulose fibers.
34774596	4	53	theme	mechanical	660:669	arg1	strength					671:678	the mechanical strength	656:678	the mechanical strength with slightly improved flexibility	656:713	The incorporation of ZnSNPs improved the mechanical strength, whereas PET slightly decreased the strength, but the combined addition of ZnSNP and PET maintained the mechanical strength with slightly improved flexibility.
34774596	4	54	theme	ZnSNP	631:635	arg1	addition					619:626	the combined addition	606:626	the combined addition of ZnSNP and PET	606:643	The incorporation of ZnSNPs improved the mechanical strength, whereas PET slightly decreased the strength, but the combined addition of ZnSNP and PET maintained the mechanical strength with slightly improved flexibility.
34774596	4	55	theme	ZnSNPs	516:521	arg1	incorporation					499:511	The incorporation	495:511	The incorporation of ZnSNPs	495:521	The incorporation of ZnSNPs improved the mechanical strength, whereas PET slightly decreased the strength, but the combined addition of ZnSNP and PET maintained the mechanical strength with slightly improved flexibility.
34774596	4	56	theme	improved	694:701	arg1	flexibility					703:713	slightly improved flexibility	685:713	slightly improved flexibility	685:713	The incorporation of ZnSNPs improved the mechanical strength, whereas PET slightly decreased the strength, but the combined addition of ZnSNP and PET maintained the mechanical strength with slightly improved flexibility.
34774596	7	57	used	used	1103:1106	arg2	ZnSNP					987:991	ZnSNP	987:991	ZnSNP	987:991	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34774596	7	57	used	used	1103:1106	arg2	PET					997:999	PET	997:999	PET	997:999	The ZnSNP and PET incorporated binary composite films with enhanced physical and functional properties are likely to be used in active food packaging applications.
34923382	6	0	theme	oxidation	1308:1316	arg1	materials					1318:1326	the fabricated slow-release oxidation materials	1280:1326	the fabricated slow-release oxidation materials	1280:1326	Therefore, the fabricated slow-release oxidation materials exhibit application potential for the remediation of organic polluted groundwater and soil.
34923382	5	1	dep	rate	1135:1138	arg1	%					1125:1125	%	1125:1125	%	1125:1125	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	5	2	theme	%	1074:1074	arg1	rate					1061:1064	A pyrene removal rate	1044:1064	A pyrene removal rate of 90.53%	1044:1074	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	4	3	theme	removal	1010:1016	arg1	efficiency					1018:1027	the removal efficiency	1006:1027	the removal efficiency of pollutants	1006:1041	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation were studied, and all the results suggested that urea played an important role in PS slow-release and can also catalyze the activation of PS by iron to further produce radicals and improve the removal efficiency of pollutants.
34923382	0	4	theme	organic	83:89	arg1	pollutants					91:100	organic pollutants	83:100	organic pollutants	83:100	A novel chitosan-urea encapsulated material for persulfate slow-release to degrade organic pollutants.
34923382	4	5	theme	pollutants	1032:1041	arg1	efficiency					1018:1027	the removal efficiency	1006:1027	the removal efficiency of pollutants	1006:1041	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation were studied, and all the results suggested that urea played an important role in PS slow-release and can also catalyze the activation of PS by iron to further produce radicals and improve the removal efficiency of pollutants.
34923382	2	6	theme	image	520:524	arg1	results					526:532	approximately 2-3 µm according to the particle-size distribution and SEM image results	447:532	approximately 2-3 µm according to the particle-size distribution and SEM image results	447:532	The obtained CS-U@PS exhibits spherical shapes with a uniform size of approximately 2-3 µm according to the particle-size distribution and SEM image results.
34923382	5	7	theme	aqueous	1092:1098	arg1	solutions					1100:1108	aqueous solutions	1092:1108	aqueous solutions	1092:1108	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	5	8	dep	%	1125:1125	arg1	80					1123:1124	80	1123:1124	80	1123:1124	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	4	9	theme	PS	752:753	arg1	dosages					755:761	urea and PS dosages	743:761	urea and PS dosages	743:761	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation were studied, and all the results suggested that urea played an important role in PS slow-release and can also catalyze the activation of PS by iron to further produce radicals and improve the removal efficiency of pollutants.
34923382	5	10	theme	@	1206:1206	arg1	PS					1207:1208	CS-U@PS	1202:1208	CS-U@PS activated by Fe2+ with citric acid as the chelating agent	1202:1266	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	4	11	theme	PS	955:956	arg1	activation					941:950	the activation	937:950	the activation of PS by iron	937:964	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation were studied, and all the results suggested that urea played an important role in PS slow-release and can also catalyze the activation of PS by iron to further produce radicals and improve the removal efficiency of pollutants.
34923382	2	12	theme	SEM	516:518	arg1	results					526:532	approximately 2-3 µm according to the particle-size distribution and SEM image results	447:532	approximately 2-3 µm according to the particle-size distribution and SEM image results	447:532	The obtained CS-U@PS exhibits spherical shapes with a uniform size of approximately 2-3 µm according to the particle-size distribution and SEM image results.
34923382	3	13	theme	slow-release	539:550	arg1	mechanism					552:560	The slow-release mechanism	535:560	The slow-release mechanism	535:560	The slow-release mechanism was proposed through a kinetics model study and the Ritger-Peppas model fit well (r2 = 0.9699) to indicate that the slow-release process is non-Fickian diffusion.
34923382	5	14	with	Fe2+	1223:1226	arg1	acid					1240:1243	citric acid	1233:1243	citric acid	1233:1243	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	6	15	theme	soil	1414:1417	arg1	remediation					1366:1376	the remediation	1362:1376	the remediation of organic polluted groundwater and soil	1362:1417	Therefore, the fabricated slow-release oxidation materials exhibit application potential for the remediation of organic polluted groundwater and soil.
34923382	5	16	theme	chelating	1252:1260	arg1	agent					1262:1266	the chelating agent	1248:1266	the chelating agent	1248:1266	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	1	17	theme	slow-release	158:169	arg1	persulfate					147:156	persulfate	147:156	persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene)	147:238	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	6	18	theme	application	1336:1346	arg1	potential					1348:1356	application potential	1336:1356	application potential for the remediation of organic polluted groundwater and soil	1336:1417	Therefore, the fabricated slow-release oxidation materials exhibit application potential for the remediation of organic polluted groundwater and soil.
34923382	1	19	theme	first	365:369	arg1	time					371:374	the first time	361:374	the first time	361:374	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	4	20	theme	dosages	755:761	arg1	influences					729:738	The influences	725:738	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation	725:815	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation were studied, and all the results suggested that urea played an important role in PS slow-release and can also catalyze the activation of PS by iron to further produce radicals and improve the removal efficiency of pollutants.
34923382	2	21	theme	obtained	381:388	arg1	PS					395:396	The obtained CS-U@PS	377:396	The obtained CS-U@PS	377:396	The obtained CS-U@PS exhibits spherical shapes with a uniform size of approximately 2-3 µm according to the particle-size distribution and SEM image results.
34923382	0	22	theme	novel	2:6	arg1	chitosan-urea					8:20	A novel chitosan-urea	0:20	A novel chitosan-urea	0:20	A novel chitosan-urea encapsulated material for persulfate slow-release to degrade organic pollutants.
34923382	3	23	theme	non-Fickian	702:712	arg1	process					691:697	the slow-release process	674:697	the slow-release process	674:697	The slow-release mechanism was proposed through a kinetics model study and the Ritger-Peppas model fit well (r2 = 0.9699) to indicate that the slow-release process is non-Fickian diffusion.
34923382	3	23	theme	non-Fickian	702:712	arg1	diffusion					714:722	non-Fickian diffusion	702:722	non-Fickian diffusion	702:722	The slow-release mechanism was proposed through a kinetics model study and the Ritger-Peppas model fit well (r2 = 0.9699) to indicate that the slow-release process is non-Fickian diffusion.
34923382	3	24	dep	model	594:598	arg1	study					600:604	study	600:604	study	600:604	The slow-release mechanism was proposed through a kinetics model study and the Ritger-Peppas model fit well (r2 = 0.9699) to indicate that the slow-release process is non-Fickian diffusion.
34923382	6	25	theme	organic	1381:1387	arg1	groundwater					1398:1408	organic polluted groundwater	1381:1408	organic polluted groundwater	1381:1408	Therefore, the fabricated slow-release oxidation materials exhibit application potential for the remediation of organic polluted groundwater and soil.
34923382	4	26	from	influences	729:738	arg1	degradation					805:815	methyl orange degradation	791:815	methyl orange degradation	791:815	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation were studied, and all the results suggested that urea played an important role in PS slow-release and can also catalyze the activation of PS by iron to further produce radicals and improve the removal efficiency of pollutants.
34923382	1	27	theme	novel	105:109	arg1	material					124:131	A novel eco-friendly material	103:131	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene)	103:238	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	1	27	theme	novel	105:109	arg1	PS					139:140	CS-U@PS	134:140	CS-U@PS	134:140	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	5	28	theme	citric	1233:1238	arg1	acid					1240:1243	citric acid	1233:1243	citric acid	1233:1243	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	2	29	theme	spherical	407:415	arg1	shapes					417:422	spherical shapes	407:422	spherical shapes	407:422	The obtained CS-U@PS exhibits spherical shapes with a uniform size of approximately 2-3 µm according to the particle-size distribution and SEM image results.
34923382	6	30	theme	polluted	1389:1396	arg1	groundwater					1398:1408	organic polluted groundwater	1381:1408	organic polluted groundwater	1381:1408	Therefore, the fabricated slow-release oxidation materials exhibit application potential for the remediation of organic polluted groundwater and soil.
34923382	5	31	theme	removal	1127:1133	arg1	rate					1135:1138	an above 80% removal rate	1114:1138	an above 80% removal rate	1114:1138	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	1	32	theme	eco-friendly	111:122	arg1	material					124:131	A novel eco-friendly material	103:131	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene)	103:238	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	1	32	theme	eco-friendly	111:122	arg1	PS					139:140	CS-U@PS	134:140	CS-U@PS	134:140	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	5	33	theme	CS-U	1202:1205	arg1	PS					1207:1208	CS-U@PS	1202:1208	CS-U@PS activated by Fe2+ with citric acid as the chelating agent	1202:1266	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	2	34	theme	2-3 µm	461:466	arg1	results					526:532	approximately 2-3 µm according to the particle-size distribution and SEM image results	447:532	approximately 2-3 µm according to the particle-size distribution and SEM image results	447:532	The obtained CS-U@PS exhibits spherical shapes with a uniform size of approximately 2-3 µm according to the particle-size distribution and SEM image results.
34923382	6	35	theme	groundwater	1398:1408	arg1	remediation					1366:1376	the remediation	1362:1376	the remediation of organic polluted groundwater and soil	1362:1417	Therefore, the fabricated slow-release oxidation materials exhibit application potential for the remediation of organic polluted groundwater and soil.
34923382	5	36	theme	acidic	1163:1168	arg1	environments					1186:1197	weakly acidic or neutral soil environments	1156:1197	weakly acidic or neutral soil environments	1156:1197	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	2	37	theme	CS-U	390:393	arg1	PS					395:396	The obtained CS-U@PS	377:396	The obtained CS-U@PS	377:396	The obtained CS-U@PS exhibits spherical shapes with a uniform size of approximately 2-3 µm according to the particle-size distribution and SEM image results.
34923382	1	38	theme	encapsulated	287:298	arg1	materials					310:318	the encapsulated framework materials	283:318	the encapsulated framework materials	283:318	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	1	38	theme	encapsulated	287:298	arg1	urea					275:278	urea	275:278	urea	275:278	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	1	38	theme	encapsulated	287:298	arg1	chitosan					262:269	chitosan	262:269	chitosan	262:269	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	2	39	theme	results	526:532	arg1	size					439:442	a uniform size	429:442	a uniform size of approximately 2-3 µm according to the particle-size distribution and SEM image results	429:532	The obtained CS-U@PS exhibits spherical shapes with a uniform size of approximately 2-3 µm according to the particle-size distribution and SEM image results.
34923382	5	40	theme	pyrene	1046:1051	arg1	rate					1061:1064	A pyrene removal rate	1044:1064	A pyrene removal rate of 90.53%	1044:1074	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	4	41	theme	orange	798:803	arg1	degradation					805:815	methyl orange degradation	791:815	methyl orange degradation	791:815	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation were studied, and all the results suggested that urea played an important role in PS slow-release and can also catalyze the activation of PS by iron to further produce radicals and improve the removal efficiency of pollutants.
34923382	2	42	theme	@	394:394	arg1	PS					395:396	The obtained CS-U@PS	377:396	The obtained CS-U@PS	377:396	The obtained CS-U@PS exhibits spherical shapes with a uniform size of approximately 2-3 µm according to the particle-size distribution and SEM image results.
34923382	1	43	theme	framework	300:308	arg1	materials					310:318	the encapsulated framework materials	283:318	the encapsulated framework materials	283:318	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	1	43	theme	framework	300:308	arg1	urea					275:278	urea	275:278	urea	275:278	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	1	43	theme	framework	300:308	arg1	chitosan					262:269	chitosan	262:269	chitosan	262:269	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	6	44	theme	fabricated	1284:1293	arg1	materials					1318:1326	the fabricated slow-release oxidation materials	1280:1326	the fabricated slow-release oxidation materials	1280:1326	Therefore, the fabricated slow-release oxidation materials exhibit application potential for the remediation of organic polluted groundwater and soil.
34923382	5	45	theme	removal	1053:1059	arg1	rate					1061:1064	A pyrene removal rate	1044:1064	A pyrene removal rate of 90.53%	1044:1074	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	4	46	theme	slow-release	902:913	arg1	PS					899:900	PS slow-release	899:913	PS slow-release	899:913	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation were studied, and all the results suggested that urea played an important role in PS slow-release and can also catalyze the activation of PS by iron to further produce radicals and improve the removal efficiency of pollutants.
34923382	6	47	theme	slow-release	1295:1306	arg1	materials					1318:1326	the fabricated slow-release oxidation materials	1280:1326	the fabricated slow-release oxidation materials	1280:1326	Therefore, the fabricated slow-release oxidation materials exhibit application potential for the remediation of organic polluted groundwater and soil.
34923382	3	48	theme	kinetics	585:592	arg1	model					594:598	a kinetics model study and the Ritger-Peppas model	583:632	model	594:598	The slow-release mechanism was proposed through a kinetics model study and the Ritger-Peppas model fit well (r2 = 0.9699) to indicate that the slow-release process is non-Fickian diffusion.
34923382	3	48	theme	kinetics	585:592	arg1	r2					644:645	r2 = 0.9699	644:654	r2 = 0.9699	644:654	The slow-release mechanism was proposed through a kinetics model study and the Ritger-Peppas model fit well (r2 = 0.9699) to indicate that the slow-release process is non-Fickian diffusion.
34923382	4	49	theme	conditions	777:786	arg1	influences					729:738	The influences	725:738	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation	725:815	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation were studied, and all the results suggested that urea played an important role in PS slow-release and can also catalyze the activation of PS by iron to further produce radicals and improve the removal efficiency of pollutants.
34923382	3	50	theme	Ritger-Peppas	614:626	arg1	model					628:632	the Ritger-Peppas model	610:632	the Ritger-Peppas model	610:632	The slow-release mechanism was proposed through a kinetics model study and the Ritger-Peppas model fit well (r2 = 0.9699) to indicate that the slow-release process is non-Fickian diffusion.
34923382	1	51	theme	CS-U	134:137	arg1	material					124:131	A novel eco-friendly material	103:131	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene)	103:238	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	1	51	theme	CS-U	134:137	arg1	PS					139:140	CS-U@PS	134:140	CS-U@PS	134:140	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	4	52	theme	urea	743:746	arg1	dosages					755:761	urea and PS dosages	743:761	urea and PS dosages	743:761	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation were studied, and all the results suggested that urea played an important role in PS slow-release and can also catalyze the activation of PS by iron to further produce radicals and improve the removal efficiency of pollutants.
34923382	3	53	dep	fit	634:636	arg1	model					594:598	a kinetics model study and the Ritger-Peppas model	583:632	model	594:598	The slow-release mechanism was proposed through a kinetics model study and the Ritger-Peppas model fit well (r2 = 0.9699) to indicate that the slow-release process is non-Fickian diffusion.
34923382	3	53	dep	fit	634:636	arg1	r2					644:645	r2 = 0.9699	644:654	r2 = 0.9699	644:654	The slow-release mechanism was proposed through a kinetics model study and the Ritger-Peppas model fit well (r2 = 0.9699) to indicate that the slow-release process is non-Fickian diffusion.
34923382	4	54	theme	important	881:889	arg1	role					891:894	an important role	878:894	an important role	878:894	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation were studied, and all the results suggested that urea played an important role in PS slow-release and can also catalyze the activation of PS by iron to further produce radicals and improve the removal efficiency of pollutants.
34923382	4	55	theme	oxidative	767:775	arg1	conditions					777:786	oxidative conditions	767:786	oxidative conditions	767:786	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation were studied, and all the results suggested that urea played an important role in PS slow-release and can also catalyze the activation of PS by iron to further produce radicals and improve the removal efficiency of pollutants.
34923382	1	56	theme	@	138:138	arg1	material					124:131	A novel eco-friendly material	103:131	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene)	103:238	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	1	56	theme	@	138:138	arg1	PS					139:140	CS-U@PS	134:140	CS-U@PS	134:140	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	2	57	theme	particle-size	485:497	arg1	distribution					499:510	the particle-size distribution	481:510	the particle-size distribution	481:510	The obtained CS-U@PS exhibits spherical shapes with a uniform size of approximately 2-3 µm according to the particle-size distribution and SEM image results.
34923382	1	58	theme	methyl	214:219	arg1	pollutants					202:211	organic pollutants	194:211	organic pollutants (methyl orange and pyrene)	194:238	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	1	58	theme	methyl	214:219	arg1	orange					221:226	methyl orange	214:226	methyl orange	214:226	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	4	59	theme	methyl	791:796	arg1	degradation					805:815	methyl orange degradation	791:815	methyl orange degradation	791:815	The influences of urea and PS dosages and oxidative conditions on methyl orange degradation were studied, and all the results suggested that urea played an important role in PS slow-release and can also catalyze the activation of PS by iron to further produce radicals and improve the removal efficiency of pollutants.
34923382	1	60	theme	organic	194:200	arg1	pyrene					232:237	pyrene	232:237	pyrene	232:237	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	1	60	theme	organic	194:200	arg1	pollutants					202:211	organic pollutants	194:211	organic pollutants (methyl orange and pyrene)	194:238	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	1	60	theme	organic	194:200	arg1	orange					221:226	methyl orange	214:226	methyl orange	214:226	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	5	61	theme	neutral	1173:1179	arg1	environments					1186:1197	weakly acidic or neutral soil environments	1156:1197	weakly acidic or neutral soil environments	1156:1197	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
34923382	3	62	theme	slow-release	678:689	arg1	process					691:697	the slow-release process	674:697	the slow-release process	674:697	The slow-release mechanism was proposed through a kinetics model study and the Ritger-Peppas model fit well (r2 = 0.9699) to indicate that the slow-release process is non-Fickian diffusion.
34923382	3	62	theme	slow-release	678:689	arg1	diffusion					714:722	non-Fickian diffusion	702:722	non-Fickian diffusion	702:722	The slow-release mechanism was proposed through a kinetics model study and the Ritger-Peppas model fit well (r2 = 0.9699) to indicate that the slow-release process is non-Fickian diffusion.
34923382	1	63	dep	pollutants	202:211	arg1	pyrene					232:237	pyrene	232:237	pyrene	232:237	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	1	63	dep	pollutants	202:211	arg1	pollutants					202:211	organic pollutants	194:211	organic pollutants (methyl orange and pyrene)	194:238	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	1	63	dep	pollutants	202:211	arg1	orange					221:226	methyl orange	214:226	methyl orange	214:226	A novel eco-friendly material (CS-U@PS) for persulfate slow-release to effectively degrade organic pollutants (methyl orange and pyrene) was synthesized using chitosan and urea as the encapsulated framework materials via an emulsion cross-linking method for the first time.
34923382	2	64	theme	uniform	431:437	arg1	size					439:442	a uniform size	429:442	a uniform size of approximately 2-3 µm according to the particle-size distribution and SEM image results	429:532	The obtained CS-U@PS exhibits spherical shapes with a uniform size of approximately 2-3 µm according to the particle-size distribution and SEM image results.
34923382	5	65	theme	soil	1181:1184	arg1	environments					1186:1197	weakly acidic or neutral soil environments	1156:1197	weakly acidic or neutral soil environments	1156:1197	A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent.
33571589	5	0	theme	upper	739:743	arg1	contact					772:778	direct contact	765:778	direct contact with the skin	765:792	As the upper layer, it can avoid direct contact with the skin and inhibit microbial invasion.
33571589	5	0	theme	upper	739:743	arg1	layer					745:749	the upper layer	735:749	the upper layer	735:749	As the upper layer, it can avoid direct contact with the skin and inhibit microbial invasion.
33571589	7	1	theme	layer	1123:1127	arg1	action					1093:1098	the synergistic antibacterial action	1063:1098	the synergistic antibacterial action of the upper and lower layer	1063:1127	Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer.
33571589	7	2	theme	ascending	1039:1047	arg1	order					1049:1053	ascending order	1039:1053	ascending order	1039:1053	Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer.
33571589	1	3	theme	loaded	174:179	arg1	layers					314:319	the upper and lower layers	294:319	the upper and lower layers	294:319	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	3	theme	loaded	174:179	arg1	nanoparticles					190:202	Ag-Metal-organic framework loaded chitosan nanoparticles	147:202	Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs)	147:225	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	3	theme	loaded	174:179	arg1	CSNPs					220:224	0.1%Ag@MOF/1.5%CSNPs	205:224	0.1%Ag@MOF/1.5%CSNPs	205:224	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	3	theme	loaded	174:179	arg1	alginate/chitosan					256:272	polyvinyl alcohol/sodium alginate/chitosan	231:272	polyvinyl alcohol/sodium alginate/chitosan (PACS)	231:279	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	4	theme	alcohol/sodium	241:254	arg1	alginate/chitosan					256:272	polyvinyl alcohol/sodium alginate/chitosan	231:272	polyvinyl alcohol/sodium alginate/chitosan (PACS)	231:279	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	4	theme	alcohol/sodium	241:254	arg1	layers					314:319	the upper and lower layers	294:319	the upper and lower layers	294:319	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	4	theme	alcohol/sodium	241:254	arg1	nanoparticles					190:202	Ag-Metal-organic framework loaded chitosan nanoparticles	147:202	Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs)	147:225	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	4	theme	alcohol/sodium	241:254	arg1	PACS					275:278	PACS	275:278	PACS	275:278	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	7	5	from	activity	1027:1034	arg1	order					1049:1053	ascending order	1039:1053	ascending order	1039:1053	Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer.
33571589	8	6	theme	In	1130:1131	arg1	evaluation					1138:1147	In vivo evaluation	1130:1147	In vivo evaluation	1130:1147	In vivo evaluation showed that both bilayer and PACS could significantly accelerate the wound healing, and the bilayer dressing showed more complete re-epithelialization with less inflammatory cells.
33571589	1	7	theme	chitosan	181:188	arg1	layers					314:319	the upper and lower layers	294:319	the upper and lower layers	294:319	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	7	theme	chitosan	181:188	arg1	nanoparticles					190:202	Ag-Metal-organic framework loaded chitosan nanoparticles	147:202	Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs)	147:225	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	7	theme	chitosan	181:188	arg1	CSNPs					220:224	0.1%Ag@MOF/1.5%CSNPs	205:224	0.1%Ag@MOF/1.5%CSNPs	205:224	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	7	theme	chitosan	181:188	arg1	alginate/chitosan					256:272	polyvinyl alcohol/sodium alginate/chitosan	231:272	polyvinyl alcohol/sodium alginate/chitosan (PACS)	231:279	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	9	8	theme	wound	1407:1411	arg1	healing					1413:1419	wound healing	1407:1419	wound healing	1407:1419	In summary, this new bilayer composite is an ideal dressing for accelerating wound healing.
33571589	0	9	theme	healing	110:116	arg1	applications					118:129	wound healing applications	104:129	wound healing applications	104:129	Ag@MOF-loaded chitosan nanoparticle and polyvinyl alcohol/sodium alginate/chitosan bilayer dressing for wound healing applications.
33571589	5	10	with	contact	772:778	arg1	skin					789:792	the skin	785:792	the skin	785:792	As the upper layer, it can avoid direct contact with the skin and inhibit microbial invasion.
33571589	6	11	theme	blood	924:928	arg1	coagulation					930:940	blood coagulation	924:940	blood coagulation	924:940	In addition, the bilayer can adhere to a large number of red blood cells and platelets, promoting blood coagulation and cell proliferation.
33571589	0	12	theme	wound	104:108	arg1	healing					110:116	wound healing	104:116	wound healing applications	104:129	Ag@MOF-loaded chitosan nanoparticle and polyvinyl alcohol/sodium alginate/chitosan bilayer dressing for wound healing applications.
33571589	7	13	theme	Ag	966:967	arg1	MOF					969:971	Ag@MOF	966:971	Ag@MOF	966:971	Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer.
33571589	8	14	theme	bilayer	1241:1247	arg1	dressing					1249:1256	the bilayer dressing	1237:1256	the bilayer dressing	1237:1256	In vivo evaluation showed that both bilayer and PACS could significantly accelerate the wound healing, and the bilayer dressing showed more complete re-epithelialization with less inflammatory cells.
33571589	3	15	theme	pore	479:482	arg1	distribution					489:500	uniform pore size distribution	471:500	uniform pore size distribution	471:500	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	9	16	theme	ideal	1375:1379	arg1	dressing					1381:1388	an ideal dressing	1372:1388	an ideal dressing for accelerating wound healing	1372:1419	In summary, this new bilayer composite is an ideal dressing for accelerating wound healing.
33571589	9	16	theme	ideal	1375:1379	arg1	composite					1359:1367	this new bilayer composite	1342:1367	this new bilayer composite	1342:1367	In summary, this new bilayer composite is an ideal dressing for accelerating wound healing.
33571589	4	17	theme	antibacterial	682:694	arg1	activity					696:703	excellent antibacterial activity	672:703	excellent antibacterial activity	672:703	The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility.
33571589	1	18	theme	bilayer	347:353	arg1	dressing					365:372	a bilayer composite dressing	345:372	a bilayer composite dressing for wound healing	345:390	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	7	19	theme	antibacterial	1079:1091	arg1	action					1093:1098	the synergistic antibacterial action	1063:1098	the synergistic antibacterial action of the upper and lower layer	1063:1127	Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer.
33571589	4	20	theme	poor	709:712	arg1	biocompatibility					714:729	poor biocompatibility	709:729	poor biocompatibility	709:729	The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility.
33571589	3	21	theme	good	503:506	arg1	retention					514:522	good water retention	503:522	good water retention	503:522	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	4	22	theme	upper	635:639	arg1	MOF/CSNPs					651:659	Ag@MOF/CSNPs	648:659	Ag@MOF/CSNPs	648:659	The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility.
33571589	4	22	theme	upper	635:639	arg1	layer					641:645	The upper layer	631:645	The upper layer (Ag@MOF/CSNPs)	631:660	The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility.
33571589	7	23	theme	upper	1107:1111	arg1	layer					1123:1127	the upper and lower layer	1103:1127	the upper and lower layer	1103:1127	Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer.
33571589	1	24	theme	composite	355:363	arg1	dressing					365:372	a bilayer composite dressing	345:372	a bilayer composite dressing for wound healing	345:390	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	5	25	theme	direct	765:770	arg1	contact					772:778	direct contact	765:778	direct contact with the skin	765:792	As the upper layer, it can avoid direct contact with the skin and inhibit microbial invasion.
33571589	5	25	theme	direct	765:770	arg1	layer					745:749	the upper layer	735:749	the upper layer	735:749	As the upper layer, it can avoid direct contact with the skin and inhibit microbial invasion.
33571589	3	26	theme	water	508:512	arg1	retention					514:522	good water retention	503:522	good water retention	503:522	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	0	27	theme	@	2:2	arg1	nanoparticle					23:34	Ag@MOF-loaded chitosan nanoparticle	0:34	Ag@MOF-loaded chitosan nanoparticle	0:34	Ag@MOF-loaded chitosan nanoparticle and polyvinyl alcohol/sodium alginate/chitosan bilayer dressing for wound healing applications.
33571589	3	28	contain	had	467:469	arg1	PACS					461:464	PACS	461:464	PACS	461:464	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	3	28	contain	had	467:469	arg2	retention					514:522	good water retention	503:522	good water retention	503:522	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	3	28	contain	had	467:469	arg2	permeability					547:558	water vapor permeability	535:558	water vapor permeability	535:558	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	3	28	contain	had	467:469	arg2	distribution					489:500	uniform pore size distribution	471:500	uniform pore size distribution	471:500	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	3	28	contain	had	467:469	arg2	biocompatibility					565:580	biocompatibility	565:580	biocompatibility	565:580	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	3	28	contain	had	467:469	arg2	swelling					525:532	swelling	525:532	swelling	525:532	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	3	28	contain	had	467:469	arg1	layer					454:458	The lower layer	444:458	The lower layer (PACS)	444:465	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	3	29	theme	water	535:539	arg1	permeability					547:558	water vapor permeability	535:558	water vapor permeability	535:558	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	1	30	used	used	286:289	arg2	PACS					275:278	PACS	275:278	PACS	275:278	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	30	used	used	286:289	arg2	nanoparticles					190:202	Ag-Metal-organic framework loaded chitosan nanoparticles	147:202	Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs)	147:225	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	30	used	used	286:289	arg2	alginate/chitosan					256:272	polyvinyl alcohol/sodium alginate/chitosan	231:272	polyvinyl alcohol/sodium alginate/chitosan (PACS)	231:279	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	30	used	used	286:289	arg2	CSNPs					220:224	0.1%Ag@MOF/1.5%CSNPs	205:224	0.1%Ag@MOF/1.5%CSNPs	205:224	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	30	used	used	286:289	arg2	layers					314:319	the upper and lower layers	294:319	the upper and lower layers	294:319	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	31	theme	0.1	205:207	arg1	%					208:208	%	208:208	%	208:208	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	0	32	theme	Ag	0:1	arg1	nanoparticle					23:34	Ag@MOF-loaded chitosan nanoparticle	0:34	Ag@MOF-loaded chitosan nanoparticle	0:34	Ag@MOF-loaded chitosan nanoparticle and polyvinyl alcohol/sodium alginate/chitosan bilayer dressing for wound healing applications.
33571589	3	33	theme	vapor	541:545	arg1	permeability					547:558	water vapor permeability	535:558	water vapor permeability	535:558	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	1	34	theme	%	208:208	arg1	CSNPs					220:224	0.1%Ag@MOF/1.5%CSNPs	205:224	0.1%Ag@MOF/1.5%CSNPs	205:224	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	34	theme	%	208:208	arg1	nanoparticles					190:202	Ag-Metal-organic framework loaded chitosan nanoparticles	147:202	Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs)	147:225	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	0	35	theme	chitosan	14:21	arg1	nanoparticle					23:34	Ag@MOF-loaded chitosan nanoparticle	0:34	Ag@MOF-loaded chitosan nanoparticle	0:34	Ag@MOF-loaded chitosan nanoparticle and polyvinyl alcohol/sodium alginate/chitosan bilayer dressing for wound healing applications.
33571589	6	36	theme	platelets	903:911	arg1	number					873:878	a large number	865:878	a large number of red blood cells and platelets	865:911	In addition, the bilayer can adhere to a large number of red blood cells and platelets, promoting blood coagulation and cell proliferation.
33571589	7	37	theme	@	983:983	arg1	MOF/CSNPs					984:992	Ag@MOF/CSNPs	981:992	Ag@MOF/CSNPs	981:992	Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer.
33571589	9	38	theme	bilayer	1351:1357	arg1	dressing					1381:1388	an ideal dressing	1372:1388	an ideal dressing for accelerating wound healing	1372:1419	In summary, this new bilayer composite is an ideal dressing for accelerating wound healing.
33571589	9	38	theme	bilayer	1351:1357	arg1	composite					1359:1367	this new bilayer composite	1342:1367	this new bilayer composite	1342:1367	In summary, this new bilayer composite is an ideal dressing for accelerating wound healing.
33571589	7	39	theme	antibacterial	1013:1025	arg1	activity					1027:1034	antibacterial activity	1013:1034	antibacterial activity in ascending order	1013:1053	Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer.
33571589	1	40	theme	Ag	209:210	arg1	CSNPs					220:224	0.1%Ag@MOF/1.5%CSNPs	205:224	0.1%Ag@MOF/1.5%CSNPs	205:224	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	40	theme	Ag	209:210	arg1	nanoparticles					190:202	Ag-Metal-organic framework loaded chitosan nanoparticles	147:202	Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs)	147:225	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	0	41	theme	MOF-loaded	3:12	arg1	nanoparticle					23:34	Ag@MOF-loaded chitosan nanoparticle	0:34	Ag@MOF-loaded chitosan nanoparticle	0:34	Ag@MOF-loaded chitosan nanoparticle and polyvinyl alcohol/sodium alginate/chitosan bilayer dressing for wound healing applications.
33571589	8	42	dep	In	1130:1131	arg1	vivo					1133:1136	vivo	1133:1136	vivo	1133:1136	In vivo evaluation showed that both bilayer and PACS could significantly accelerate the wound healing, and the bilayer dressing showed more complete re-epithelialization with less inflammatory cells.
33571589	3	43	theme	size	484:487	arg1	distribution					489:500	uniform pore size distribution	471:500	uniform pore size distribution	471:500	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	9	44	theme	new	1347:1349	arg1	dressing					1381:1388	an ideal dressing	1372:1388	an ideal dressing for accelerating wound healing	1372:1419	In summary, this new bilayer composite is an ideal dressing for accelerating wound healing.
33571589	9	44	theme	new	1347:1349	arg1	composite					1359:1367	this new bilayer composite	1342:1367	this new bilayer composite	1342:1367	In summary, this new bilayer composite is an ideal dressing for accelerating wound healing.
33571589	1	45	theme	@	211:211	arg1	CSNPs					220:224	0.1%Ag@MOF/1.5%CSNPs	205:224	0.1%Ag@MOF/1.5%CSNPs	205:224	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	45	theme	@	211:211	arg1	nanoparticles					190:202	Ag-Metal-organic framework loaded chitosan nanoparticles	147:202	Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs)	147:225	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	6	46	theme	cells	893:897	arg1	number					873:878	a large number	865:878	a large number of red blood cells and platelets	865:911	In addition, the bilayer can adhere to a large number of red blood cells and platelets, promoting blood coagulation and cell proliferation.
33571589	1	47	theme	wound	378:382	arg1	healing					384:390	wound healing	378:390	wound healing	378:390	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	4	48	theme	@	650:650	arg1	MOF/CSNPs					651:659	Ag@MOF/CSNPs	648:659	Ag@MOF/CSNPs	648:659	The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility.
33571589	4	48	theme	@	650:650	arg1	layer					641:645	The upper layer	631:645	The upper layer (Ag@MOF/CSNPs)	631:660	The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility.
33571589	6	49	theme	blood	887:891	arg1	cells					893:897	red blood cells	883:897	red blood cells	883:897	In addition, the bilayer can adhere to a large number of red blood cells and platelets, promoting blood coagulation and cell proliferation.
33571589	7	50	theme	Ag	981:982	arg1	MOF/CSNPs					984:992	Ag@MOF/CSNPs	981:992	Ag@MOF/CSNPs	981:992	Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer.
33571589	6	51	theme	cell	946:949	arg1	proliferation					951:963	cell proliferation	946:963	cell proliferation	946:963	In addition, the bilayer can adhere to a large number of red blood cells and platelets, promoting blood coagulation and cell proliferation.
33571589	5	52	theme	microbial	806:814	arg1	invasion					816:823	microbial invasion	806:823	microbial invasion	806:823	As the upper layer, it can avoid direct contact with the skin and inhibit microbial invasion.
33571589	1	53	theme	%	219:219	arg1	CSNPs					220:224	0.1%Ag@MOF/1.5%CSNPs	205:224	0.1%Ag@MOF/1.5%CSNPs	205:224	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	53	theme	%	219:219	arg1	nanoparticles					190:202	Ag-Metal-organic framework loaded chitosan nanoparticles	147:202	Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs)	147:225	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	54	theme	upper	298:302	arg1	alginate/chitosan					256:272	polyvinyl alcohol/sodium alginate/chitosan	231:272	polyvinyl alcohol/sodium alginate/chitosan (PACS)	231:279	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	54	theme	upper	298:302	arg1	layers					314:319	the upper and lower layers	294:319	the upper and lower layers	294:319	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	54	theme	upper	298:302	arg1	nanoparticles					190:202	Ag-Metal-organic framework loaded chitosan nanoparticles	147:202	Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs)	147:225	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	3	55	theme	antibacterial	607:619	arg1	activity					621:628	almost no antibacterial activity	597:628	almost no antibacterial activity	597:628	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	4	56	contain	possessed	662:670	arg2	activity					696:703	excellent antibacterial activity	672:703	excellent antibacterial activity	672:703	The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility.
33571589	4	56	contain	possessed	662:670	arg1	MOF/CSNPs					651:659	Ag@MOF/CSNPs	648:659	Ag@MOF/CSNPs	648:659	The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility.
33571589	4	56	contain	possessed	662:670	arg1	layer					641:645	The upper layer	631:645	The upper layer (Ag@MOF/CSNPs)	631:660	The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility.
33571589	4	56	contain	possessed	662:670	arg2	biocompatibility					714:729	poor biocompatibility	709:729	poor biocompatibility	709:729	The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility.
33571589	4	57	theme	excellent	672:680	arg1	activity					696:703	excellent antibacterial activity	672:703	excellent antibacterial activity	672:703	The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility.
33571589	0	58	theme	polyvinyl	40:48	arg1	alcohol/sodium					50:63	polyvinyl alcohol/sodium	40:63	polyvinyl alcohol/sodium	40:63	Ag@MOF-loaded chitosan nanoparticle and polyvinyl alcohol/sodium alginate/chitosan bilayer dressing for wound healing applications.
33571589	3	59	contain	had	593:595	arg1	PACS					588:591	PACS	588:591	PACS	588:591	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	3	59	contain	had	593:595	arg2	activity					621:628	almost no antibacterial activity	597:628	almost no antibacterial activity	597:628	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	7	60	theme	lower	1117:1121	arg1	layer					1123:1127	the upper and lower layer	1103:1127	the upper and lower layer	1103:1127	Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer.
33571589	3	61	theme	uniform	471:477	arg1	distribution					489:500	uniform pore size distribution	471:500	uniform pore size distribution	471:500	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	1	62	theme	lower	308:312	arg1	alginate/chitosan					256:272	polyvinyl alcohol/sodium alginate/chitosan	231:272	polyvinyl alcohol/sodium alginate/chitosan (PACS)	231:279	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	62	theme	lower	308:312	arg1	layers					314:319	the upper and lower layers	294:319	the upper and lower layers	294:319	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	62	theme	lower	308:312	arg1	nanoparticles					190:202	Ag-Metal-organic framework loaded chitosan nanoparticles	147:202	Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs)	147:225	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	7	63	theme	@	968:968	arg1	MOF					969:971	Ag@MOF	966:971	Ag@MOF	966:971	Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer.
33571589	8	64	theme	complete	1270:1277	arg1	re-epithelialization					1279:1298	more complete re-epithelialization	1265:1298	more complete re-epithelialization	1265:1298	In vivo evaluation showed that both bilayer and PACS could significantly accelerate the wound healing, and the bilayer dressing showed more complete re-epithelialization with less inflammatory cells.
33571589	8	65	theme	inflammatory	1310:1321	arg1	cells					1323:1327	less inflammatory cells	1305:1327	less inflammatory cells	1305:1327	In vivo evaluation showed that both bilayer and PACS could significantly accelerate the wound healing, and the bilayer dressing showed more complete re-epithelialization with less inflammatory cells.
33571589	8	66	theme	wound	1218:1222	arg1	healing					1224:1230	the wound healing	1214:1230	the wound healing	1214:1230	In vivo evaluation showed that both bilayer and PACS could significantly accelerate the wound healing, and the bilayer dressing showed more complete re-epithelialization with less inflammatory cells.
33571589	9	67	from	dressing	1381:1388	arg1	summary					1333:1339	summary	1333:1339	summary	1333:1339	In summary, this new bilayer composite is an ideal dressing for accelerating wound healing.
33571589	4	68	theme	Ag	648:649	arg1	MOF/CSNPs					651:659	Ag@MOF/CSNPs	648:659	Ag@MOF/CSNPs	648:659	The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility.
33571589	4	68	theme	Ag	648:649	arg1	layer					641:645	The upper layer	631:645	The upper layer (Ag@MOF/CSNPs)	631:660	The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility.
33571589	7	69	theme	synergistic	1067:1077	arg1	action					1093:1098	the synergistic antibacterial action	1063:1098	the synergistic antibacterial action of the upper and lower layer	1063:1127	Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer.
33571589	0	70	theme	bilayer	83:89	arg1	dressing					91:98	bilayer dressing	83:98	bilayer dressing for wound healing applications	83:129	Ag@MOF-loaded chitosan nanoparticle and polyvinyl alcohol/sodium alginate/chitosan bilayer dressing for wound healing applications.
33571589	3	71	theme	lower	448:452	arg1	PACS					461:464	PACS	461:464	PACS	461:464	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	3	71	theme	lower	448:452	arg1	layer					454:458	The lower layer	444:458	The lower layer (PACS)	444:465	The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity.
33571589	2	72	theme	bilayer	412:418	arg1	dressing					420:427	bilayer dressing	412:427	bilayer dressing	412:427	The performance of bilayer dressing was evaluated.
33571589	1	73	theme	Ag-Metal-organic	147:162	arg1	layers					314:319	the upper and lower layers	294:319	the upper and lower layers	294:319	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	73	theme	Ag-Metal-organic	147:162	arg1	nanoparticles					190:202	Ag-Metal-organic framework loaded chitosan nanoparticles	147:202	Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs)	147:225	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	73	theme	Ag-Metal-organic	147:162	arg1	CSNPs					220:224	0.1%Ag@MOF/1.5%CSNPs	205:224	0.1%Ag@MOF/1.5%CSNPs	205:224	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	73	theme	Ag-Metal-organic	147:162	arg1	alginate/chitosan					256:272	polyvinyl alcohol/sodium alginate/chitosan	231:272	polyvinyl alcohol/sodium alginate/chitosan (PACS)	231:279	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	6	74	theme	large	867:871	arg1	number					873:878	a large number	865:878	a large number of red blood cells and platelets	865:911	In addition, the bilayer can adhere to a large number of red blood cells and platelets, promoting blood coagulation and cell proliferation.
33571589	2	75	theme	dressing	420:427	arg1	performance					397:407	The performance	393:407	The performance of bilayer dressing	393:427	The performance of bilayer dressing was evaluated.
33571589	1	76	theme	framework	164:172	arg1	layers					314:319	the upper and lower layers	294:319	the upper and lower layers	294:319	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	76	theme	framework	164:172	arg1	nanoparticles					190:202	Ag-Metal-organic framework loaded chitosan nanoparticles	147:202	Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs)	147:225	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	76	theme	framework	164:172	arg1	CSNPs					220:224	0.1%Ag@MOF/1.5%CSNPs	205:224	0.1%Ag@MOF/1.5%CSNPs	205:224	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	76	theme	framework	164:172	arg1	alginate/chitosan					256:272	polyvinyl alcohol/sodium alginate/chitosan	231:272	polyvinyl alcohol/sodium alginate/chitosan (PACS)	231:279	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	6	77	theme	red	883:885	arg1	cells					893:897	red blood cells	883:897	red blood cells	883:897	In addition, the bilayer can adhere to a large number of red blood cells and platelets, promoting blood coagulation and cell proliferation.
33571589	1	78	theme	polyvinyl	231:239	arg1	alginate/chitosan					256:272	polyvinyl alcohol/sodium alginate/chitosan	231:272	polyvinyl alcohol/sodium alginate/chitosan (PACS)	231:279	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	78	theme	polyvinyl	231:239	arg1	layers					314:319	the upper and lower layers	294:319	the upper and lower layers	294:319	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	78	theme	polyvinyl	231:239	arg1	nanoparticles					190:202	Ag-Metal-organic framework loaded chitosan nanoparticles	147:202	Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs)	147:225	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
33571589	1	78	theme	polyvinyl	231:239	arg1	PACS					275:278	PACS	275:278	PACS	275:278	In this paper, Ag-Metal-organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing.
34857304	1	0	with	engineering	193:203	arg1	compositions					236:247	compositions	236:247	compositions	236:247	3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high precision.
34857304	1	0	with	engineering	193:203	arg1	geometries					221:230	customized geometries	210:230	customized geometries	210:230	3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high precision.
34857304	3	1	theme	bone	581:584	arg1	purposes					599:606	bone regeneration purposes	581:606	bone regeneration purposes	581:606	In this work, aerogel scaffolds for bone regeneration purposes were obtained by an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels.
34857304	6	2	theme	obtained	1111:1118	arg1	biocompatible					1170:1182	biocompatible	1170:1182	biocompatible	1170:1182	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	6	2	theme	obtained	1111:1118	arg1	scaffolds					1140:1148	The obtained alginate-HA aerogel scaffolds	1107:1148	The obtained alginate-HA aerogel scaffolds	1107:1148	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	6	2	theme	obtained	1111:1118	arg1	porous					1162:1167	porous	1162:1167	porous	1162:1167	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	5	3	theme	biological	974:983	arg1	characterization					985:1000	The biological characterization	970:1000	The biological characterization of the aerogel scaffolds	970:1025	The biological characterization of the aerogel scaffolds was also carried out regarding cell viability, adhesion and migration capacity.
34857304	2	4	theme	internal	430:437	arg1	structure					439:447	well-defined internal structure	417:447	well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity	417:529	For these purposes, the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity is essential.
34857304	3	5	theme	CO2	742:744	arg1	drying					746:751	the supercritical CO2 drying	724:751	the supercritical CO2 drying of the gels	724:763	In this work, aerogel scaffolds for bone regeneration purposes were obtained by an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels.
34857304	6	6	theme	high	1190:1193	arg1	fidelity					1195:1202	high fidelity	1190:1202	high fidelity to the CAD-pattern	1190:1221	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	7	7	theme	formulations	1418:1429	arg1	presence					1394:1401	the presence	1390:1401	the presence	1390:1401	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
34857304	7	7	theme	formulations	1418:1429	arg1	positive					1448:1455	positive	1448:1455	positive	1448:1455	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
34857304	2	8	theme	bioactive	347:355	arg1	3D-scaffolds					367:378	bioactive gel-based 3D-scaffolds	347:378	bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity	347:529	For these purposes, the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity is essential.
34857304	2	9	theme	gel-based	357:365	arg1	3D-scaffolds					367:378	bioactive gel-based 3D-scaffolds	347:378	bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity	347:529	For these purposes, the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity is essential.
34857304	3	10	theme	innovative	628:637	arg1	strategy					639:646	an innovative strategy	625:646	an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels	625:763	In this work, aerogel scaffolds for bone regeneration purposes were obtained by an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels.
34857304	7	11	theme	fibroblast	1329:1338	arg1	migration					1340:1348	the fibroblast migration	1325:1348	the fibroblast migration toward the damaged area	1325:1372	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
34857304	1	12	theme	3D-printing	82:92	arg1	technology					94:103	3D-printing technology	82:103	3D-printing technology	82:103	3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high precision.
34857304	2	13	theme	biocompatible	388:400	arg1	materials					402:410	biocompatible materials	388:410	biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity	388:529	For these purposes, the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity is essential.
34857304	4	14	theme	SEM	774:776	arg1	analyses					778:785	BET and SEM analyses	766:785	BET and SEM analyses	766:785	BET and SEM analyses were performed to assess the textural parameters of the obtained aerogel scaffolds and the dimensional accuracy to the original computer-aided design (CAD) design was also evaluated.
34857304	4	15	theme	scaffolds	860:868	arg1	parameters					825:834	the textural parameters	812:834	the textural parameters of the obtained aerogel scaffolds	812:868	BET and SEM analyses were performed to assess the textural parameters of the obtained aerogel scaffolds and the dimensional accuracy to the original computer-aided design (CAD) design was also evaluated.
34857304	5	16	theme	aerogel	1009:1015	arg1	scaffolds					1017:1025	the aerogel scaffolds	1005:1025	the aerogel scaffolds	1005:1025	The biological characterization of the aerogel scaffolds was also carried out regarding cell viability, adhesion and migration capacity.
34857304	1	17	theme	customized	210:219	arg1	geometries					221:230	customized geometries	210:230	customized geometries	210:230	3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high precision.
34857304	4	18	theme	design	930:935	arg1	design					943:948	the original computer-aided design (CAD) design	902:948	the original computer-aided design (CAD) design	902:948	BET and SEM analyses were performed to assess the textural parameters of the obtained aerogel scaffolds and the dimensional accuracy to the original computer-aided design (CAD) design was also evaluated.
34857304	4	19	theme	aerogel	852:858	arg1	scaffolds					860:868	the obtained aerogel scaffolds	839:868	the obtained aerogel scaffolds	839:868	BET and SEM analyses were performed to assess the textural parameters of the obtained aerogel scaffolds and the dimensional accuracy to the original computer-aided design (CAD) design was also evaluated.
34857304	6	20	dep	porous	1162:1167	arg1	biocompatible					1170:1182	biocompatible	1170:1182	biocompatible	1170:1182	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	6	20	dep	porous	1162:1167	arg1	scaffolds					1140:1148	The obtained alginate-HA aerogel scaffolds	1107:1148	The obtained alginate-HA aerogel scaffolds	1107:1148	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	6	20	dep	porous	1162:1167	arg1	porous					1162:1167	porous	1162:1167	porous	1162:1167	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	0	21	theme	alginate-hydroxyapatite	11:33	arg1	aerogel					35:41	3D-printed alginate-hydroxyapatite aerogel	0:41	3D-printed alginate-hydroxyapatite aerogel	0:41	3D-printed alginate-hydroxyapatite aerogel scaffolds for bone tissue engineering.
34857304	4	22	theme	textural	816:823	arg1	parameters					825:834	the textural parameters	812:834	the textural parameters of the obtained aerogel scaffolds	812:868	BET and SEM analyses were performed to assess the textural parameters of the obtained aerogel scaffolds and the dimensional accuracy to the original computer-aided design (CAD) design was also evaluated.
34857304	7	23	theme	damaged	1361:1367	arg1	area					1369:1372	the damaged area	1357:1372	the damaged area	1357:1372	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
34857304	0	24	theme	3D-printed	0:9	arg1	aerogel					35:41	3D-printed alginate-hydroxyapatite aerogel	0:41	3D-printed alginate-hydroxyapatite aerogel	0:41	3D-printed alginate-hydroxyapatite aerogel scaffolds for bone tissue engineering.
34857304	4	25	theme	CAD	938:940	arg1	design					943:948	the original computer-aided design (CAD) design	902:948	the original computer-aided design (CAD) design	902:948	BET and SEM analyses were performed to assess the textural parameters of the obtained aerogel scaffolds and the dimensional accuracy to the original computer-aided design (CAD) design was also evaluated.
34857304	1	26	theme	automated	116:124	arg1	manufacturing					143:155	the automated and reproducible manufacturing	112:155	the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions	112:247	3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high precision.
34857304	4	27	theme	obtained	843:850	arg1	scaffolds					860:868	the obtained aerogel scaffolds	839:868	the obtained aerogel scaffolds	839:868	BET and SEM analyses were performed to assess the textural parameters of the obtained aerogel scaffolds and the dimensional accuracy to the original computer-aided design (CAD) design was also evaluated.
34857304	2	28	theme	dual	462:465	arg1	porosity					522:529	a dual (mesoporous and macroporous) and highly interconnected porosity	460:529	a dual (mesoporous and macroporous) and highly interconnected porosity	460:529	For these purposes, the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity is essential.
34857304	5	29	theme	scaffolds	1017:1025	arg1	characterization					985:1000	The biological characterization	970:1000	The biological characterization of the aerogel scaffolds	970:1025	The biological characterization of the aerogel scaffolds was also carried out regarding cell viability, adhesion and migration capacity.
34857304	2	30	theme	3D-scaffolds	367:378	arg1	essential					534:542	essential	534:542	essential	534:542	For these purposes, the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity is essential.
34857304	2	30	theme	3D-scaffolds	367:378	arg1	production					333:342	the production	329:342	the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity	329:529	For these purposes, the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity is essential.
34857304	2	31	theme	interconnected	507:520	arg1	porosity					522:529	a dual (mesoporous and macroporous) and highly interconnected porosity	460:529	a dual (mesoporous and macroporous) and highly interconnected porosity	460:529	For these purposes, the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity is essential.
34857304	6	32	theme	stem	1288:1291	arg1	MSCs					1300:1303	MSCs	1300:1303	MSCs	1300:1303	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	6	32	theme	stem	1288:1291	arg1	cells					1293:1297	mesenchymal stem cells	1276:1297	mesenchymal stem cells (MSCs)	1276:1304	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	1	33	with	layer-by-layer	273:286	arg1	precision					298:306	high precision	293:306	high precision	293:306	3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high precision.
34857304	2	34	with	materials	402:410	arg1	structure					439:447	well-defined internal structure	417:447	well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity	417:529	For these purposes, the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity is essential.
34857304	1	35	theme	reproducible	130:141	arg1	manufacturing					143:155	the automated and reproducible manufacturing	112:155	the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions	112:247	3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high precision.
34857304	7	36	from	terms	1460:1464	arg1	presence					1394:1401	the presence	1390:1401	the presence	1390:1401	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
34857304	7	36	from	terms	1460:1464	arg1	positive					1448:1455	positive	1448:1455	positive	1448:1455	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
34857304	5	37	theme	cell	1058:1061	arg1	viability					1063:1071	cell viability	1058:1071	cell viability	1058:1071	The biological characterization of the aerogel scaffolds was also carried out regarding cell viability, adhesion and migration capacity.
34857304	0	38	theme	bone	57:60	arg1	engineering					69:79	bone tissue engineering	57:79	bone tissue engineering	57:79	3D-printed alginate-hydroxyapatite aerogel scaffolds for bone tissue engineering.
34857304	6	39	with	porous	1162:1167	arg1	fidelity					1195:1202	high fidelity	1190:1202	high fidelity to the CAD-pattern	1190:1221	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	3	40	theme	alginate-hydroxyapatite	681:703	arg1	hydrogels					710:718	alginate-hydroxyapatite (HA) hydrogels	681:718	alginate-hydroxyapatite (HA) hydrogels	681:718	In this work, aerogel scaffolds for bone regeneration purposes were obtained by an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels.
34857304	3	40	theme	alginate-hydroxyapatite	681:703	arg1	HA					706:707	HA	706:707	HA	706:707	In this work, aerogel scaffolds for bone regeneration purposes were obtained by an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels.
34857304	6	41	dep	attachment	1244:1253	arg1	the					1240:1242	the	1240:1242	the	1240:1242	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	7	42	theme	aerogel	1410:1416	arg1	formulations					1418:1429	the aerogel formulations	1406:1429	the aerogel formulations tested	1406:1436	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
34857304	1	43	theme	layer-by-layer	273:286	arg1	materials					263:271	materials	263:271	materials layer-by-layer with high precision	263:306	3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high precision.
34857304	3	44	theme	supercritical	728:740	arg1	drying					746:751	the supercritical CO2 drying	724:751	the supercritical CO2 drying of the gels	724:763	In this work, aerogel scaffolds for bone regeneration purposes were obtained by an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels.
34857304	4	45	theme	computer-aided	915:928	arg1	design					943:948	the original computer-aided design (CAD) design	902:948	the original computer-aided design (CAD) design	902:948	BET and SEM analyses were performed to assess the textural parameters of the obtained aerogel scaffolds and the dimensional accuracy to the original computer-aided design (CAD) design was also evaluated.
34857304	2	46	theme	well-defined	417:428	arg1	structure					439:447	well-defined internal structure	417:447	well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity	417:529	For these purposes, the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity is essential.
34857304	0	47	theme	tissue	62:67	arg1	engineering					69:79	bone tissue engineering	57:79	bone tissue engineering	57:79	3D-printed alginate-hydroxyapatite aerogel scaffolds for bone tissue engineering.
34857304	6	48	theme	mesenchymal	1276:1286	arg1	MSCs					1300:1303	MSCs	1300:1303	MSCs	1300:1303	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	6	48	theme	mesenchymal	1276:1286	arg1	cells					1293:1297	mesenchymal stem cells	1276:1297	mesenchymal stem cells (MSCs)	1276:1304	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	3	49	theme	gels	760:763	arg1	3D-printing					666:676	the 3D-printing	662:676	the 3D-printing of alginate-hydroxyapatite (HA) hydrogels	662:718	In this work, aerogel scaffolds for bone regeneration purposes were obtained by an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels.
34857304	3	49	theme	gels	760:763	arg1	drying					746:751	the supercritical CO2 drying	724:751	the supercritical CO2 drying of the gels	724:763	In this work, aerogel scaffolds for bone regeneration purposes were obtained by an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels.
34857304	4	50	theme	original	906:913	arg1	design					943:948	the original computer-aided design (CAD) design	902:948	the original computer-aided design (CAD) design	902:948	BET and SEM analyses were performed to assess the textural parameters of the obtained aerogel scaffolds and the dimensional accuracy to the original computer-aided design (CAD) design was also evaluated.
34857304	3	51	theme	regeneration	586:597	arg1	purposes					599:606	bone regeneration purposes	581:606	bone regeneration purposes	581:606	In this work, aerogel scaffolds for bone regeneration purposes were obtained by an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels.
34857304	6	52	theme	cells	1293:1297	arg1	attachment					1244:1253	attachment	1244:1253	attachment	1244:1253	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	6	52	theme	cells	1293:1297	arg1	proliferation					1259:1271	proliferation	1259:1271	proliferation	1259:1271	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	3	53	theme	hydrogels	710:718	arg1	3D-printing					666:676	the 3D-printing	662:676	the 3D-printing of alginate-hydroxyapatite (HA) hydrogels	662:718	In this work, aerogel scaffolds for bone regeneration purposes were obtained by an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels.
34857304	3	53	theme	hydrogels	710:718	arg1	drying					746:751	the supercritical CO2 drying	724:751	the supercritical CO2 drying of the gels	724:763	In this work, aerogel scaffolds for bone regeneration purposes were obtained by an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels.
34857304	4	54	theme	BET	766:768	arg1	analyses					778:785	BET and SEM analyses	766:785	BET and SEM analyses	766:785	BET and SEM analyses were performed to assess the textural parameters of the obtained aerogel scaffolds and the dimensional accuracy to the original computer-aided design (CAD) design was also evaluated.
34857304	1	55	theme	functional	160:169	arg1	structures					171:180	functional structures	160:180	functional structures	160:180	3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high precision.
34857304	7	56	theme	bone	1469:1472	arg1	regeneration					1474:1485	bone regeneration	1469:1485	bone regeneration	1469:1485	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
34857304	6	57	theme	alginate-HA	1120:1130	arg1	biocompatible					1170:1182	biocompatible	1170:1182	biocompatible	1170:1182	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	6	57	theme	alginate-HA	1120:1130	arg1	scaffolds					1140:1148	The obtained alginate-HA aerogel scaffolds	1107:1148	The obtained alginate-HA aerogel scaffolds	1107:1148	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	6	57	theme	alginate-HA	1120:1130	arg1	porous					1162:1167	porous	1162:1167	porous	1162:1167	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	7	58	from	positive	1448:1455	arg1	terms					1460:1464	terms	1460:1464	terms of bone regeneration	1460:1485	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
34857304	2	59	dep	dual	462:465	arg1	mesoporous					468:477	mesoporous	468:477	mesoporous	468:477	For these purposes, the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity is essential.
34857304	2	59	dep	dual	462:465	arg1	macroporous					483:493	macroporous	483:493	macroporous	483:493	For these purposes, the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity is essential.
34857304	1	60	theme	structures	171:180	arg1	manufacturing					143:155	the automated and reproducible manufacturing	112:155	the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions	112:247	3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high precision.
34857304	1	61	theme	high	293:296	arg1	precision					298:306	high precision	293:306	high precision	293:306	3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high precision.
34857304	6	62	theme	aerogel	1132:1138	arg1	biocompatible					1170:1182	biocompatible	1170:1182	biocompatible	1170:1182	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	6	62	theme	aerogel	1132:1138	arg1	scaffolds					1140:1148	The obtained alginate-HA aerogel scaffolds	1107:1148	The obtained alginate-HA aerogel scaffolds	1107:1148	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	6	62	theme	aerogel	1132:1138	arg1	porous					1162:1167	porous	1162:1167	porous	1162:1167	The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs).
34857304	5	63	theme	migration	1087:1095	arg1	capacity					1097:1104	migration capacity	1087:1104	migration capacity	1087:1104	The biological characterization of the aerogel scaffolds was also carried out regarding cell viability, adhesion and migration capacity.
34857304	7	64	located	observed	1378:1385	arg2	enhancement					1310:1320	An enhancement	1307:1320	An enhancement of the fibroblast migration toward the damaged area	1307:1372	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
34857304	7	64	located	observed	1378:1385	arg1	presence					1394:1401	the presence	1390:1401	the presence	1390:1401	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
34857304	7	64	located	observed	1378:1385	arg1	positive					1448:1455	positive	1448:1455	positive	1448:1455	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
34857304	7	65	theme	migration	1340:1348	arg1	enhancement					1310:1320	An enhancement	1307:1320	An enhancement of the fibroblast migration toward the damaged area	1307:1372	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
34857304	3	66	theme	aerogel	559:565	arg1	scaffolds					567:575	aerogel scaffolds	559:575	aerogel scaffolds for bone regeneration purposes	559:606	In this work, aerogel scaffolds for bone regeneration purposes were obtained by an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels.
34857304	4	67	theme	dimensional	878:888	arg1	accuracy					890:897	the dimensional accuracy	874:897	the dimensional accuracy to the original computer-aided design (CAD) design	874:948	BET and SEM analyses were performed to assess the textural parameters of the obtained aerogel scaffolds and the dimensional accuracy to the original computer-aided design (CAD) design was also evaluated.
34857304	1	68	theme	tissue	186:191	arg1	engineering					193:203	tissue engineering	186:203	tissue engineering with customized geometries and compositions	186:247	3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high precision.
34857304	7	69	theme	regeneration	1474:1485	arg1	terms					1460:1464	terms	1460:1464	terms of bone regeneration	1460:1485	An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration.
33910716	3	0	dep	nanofiber	355:363	arg1	suspensions					390:400	suspensions	390:400	suspensions	390:400	This paper reports an all-biobased TW by infiltrating cellulose nanofiber (CNF) and chitosan (CTS) suspensions into the bleached wood.
33910716	5	1	theme	TW	687:688	arg1	properties					669:678	the mechanical properties	654:678	the mechanical properties of the TW	654:688	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	4	2	theme	physical	473:480	arg1	methods					482:488	the chemical and physical methods	456:488	the chemical and physical methods	456:488	CNF was isolated by combining the chemical and physical methods, and CTS was dissolved in acetic acid, and they were infiltrated into the pores of the bleached Fir veneer wood using a vacuum jar.
33910716	7	3	theme	excellent	1019:1027	arg1	property					1042:1049	excellent UV shielding property	1019:1049	excellent UV shielding property	1019:1049	The all-biobased TW showed good thermal stability up to 315 °C and excellent UV shielding property for UV-B and UV-C.
33910716	7	4	theme	thermal	984:990	arg1	stability					992:1000	good thermal stability	979:1000	good thermal stability	979:1000	The all-biobased TW showed good thermal stability up to 315 °C and excellent UV shielding property for UV-B and UV-C.
33910716	7	5	theme	all-biobased	956:967	arg1	TW					969:970	The all-biobased TW	952:970	The all-biobased TW	952:970	The all-biobased TW showed good thermal stability up to 315 °C and excellent UV shielding property for UV-B and UV-C.
33910716	9	6	theme	tensile	1198:1204	arg1	strength					1206:1213	considerable tensile strength	1185:1213	considerable tensile strength	1185:1213	The CNF-TW showed considerable tensile strength and yield strength of more than 200 % improved from the original wood.
33910716	3	7	theme	cellulose	345:353	arg1	CNF					366:368	CNF	366:368	CNF	366:368	This paper reports an all-biobased TW by infiltrating cellulose nanofiber (CNF) and chitosan (CTS) suspensions into the bleached wood.
33910716	3	7	theme	cellulose	345:353	arg1	nanofiber					355:363	cellulose nanofiber	345:363	cellulose nanofiber (CNF)	345:369	This paper reports an all-biobased TW by infiltrating cellulose nanofiber (CNF) and chitosan (CTS) suspensions into the bleached wood.
33910716	8	8	theme	original	1152:1159	arg1	wood					1161:1164	the original wood	1148:1164	the original wood	1148:1164	The antioxidant property of the CTS-TW significantly increased as compared to the original wood.
33910716	4	9	theme	veneer	590:595	arg1	wood					597:600	the bleached Fir veneer wood	573:600	the bleached Fir veneer wood using a vacuum jar	573:619	CNF was isolated by combining the chemical and physical methods, and CTS was dissolved in acetic acid, and they were infiltrated into the pores of the bleached Fir veneer wood using a vacuum jar.
33910716	5	10	theme	mechanical	658:667	arg1	properties					669:678	the mechanical properties	654:678	the mechanical properties of the TW	654:688	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	9	11	theme	yield	1219:1223	arg1	strength					1225:1232	yield strength	1219:1232	yield strength	1219:1232	The CNF-TW showed considerable tensile strength and yield strength of more than 200 % improved from the original wood.
33910716	10	12	theme	medicine	1382:1389	arg1	packaging					1391:1399	medicine packaging	1382:1399	medicine packaging	1382:1399	The potential for environment-friendly packaging applications was demonstrated by making a bag, medicine packaging, and straw for a drink.
33910716	2	13	theme	natural	244:250	arg1	substances					252:261	natural substances	244:261	natural substances	244:261	However, it is necessary to fill pores in TW with natural substances to prepare all-biobased TW.
33910716	4	14	theme	Fir	586:588	arg1	wood					597:600	the bleached Fir veneer wood	573:600	the bleached Fir veneer wood using a vacuum jar	573:619	CNF was isolated by combining the chemical and physical methods, and CTS was dissolved in acetic acid, and they were infiltrated into the pores of the bleached Fir veneer wood using a vacuum jar.
33910716	8	15	theme	antioxidant	1074:1084	arg1	property					1086:1093	The antioxidant property	1070:1093	The antioxidant property of the CTS-TW	1070:1107	The antioxidant property of the CTS-TW significantly increased as compared to the original wood.
33910716	7	16	theme	good	979:982	arg1	stability					992:1000	good thermal stability	979:1000	good thermal stability	979:1000	The all-biobased TW showed good thermal stability up to 315 °C and excellent UV shielding property for UV-B and UV-C.
33910716	10	17	theme	environment-friendly	1304:1323	arg1	applications					1335:1346	environment-friendly packaging applications	1304:1346	environment-friendly packaging applications	1304:1346	The potential for environment-friendly packaging applications was demonstrated by making a bag, medicine packaging, and straw for a drink.
33910716	1	18	theme	biobased	175:182	arg1	products					184:191	biobased products	175:191	biobased products	175:191	Transparent-wood (TW) is an emerging research topic that can be applied to biobased products.
33910716	0	19	theme	All-biobased	0:11	arg1	transparent-wood					13:28	All-biobased transparent-wood	0:28	All-biobased transparent-wood: A new approach and its environmental-friendly packaging application.	0:98	All-biobased transparent-wood: A new approach and its environmental-friendly packaging application.
33910716	6	20	theme	total	877:881	arg1	transmittance					883:895	total transmittance	877:895	80 % total transmittance	872:895	The prepared TW showed 80 % total transmittance and 30-60 % haze, suitable for solar cell application.
33910716	6	21	dep	%	875:875	arg1	transmittance					883:895	total transmittance	877:895	80 % total transmittance	872:895	The prepared TW showed 80 % total transmittance and 30-60 % haze, suitable for solar cell application.
33910716	4	22	theme	wood	597:600	arg1	pores					564:568	the pores	560:568	the pores of the bleached Fir veneer wood using a vacuum jar	560:619	CNF was isolated by combining the chemical and physical methods, and CTS was dissolved in acetic acid, and they were infiltrated into the pores of the bleached Fir veneer wood using a vacuum jar.
33910716	5	23	theme	water	747:751	arg1	morphologies					712:723	the morphologies	708:723	the morphologies	708:723	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	5	23	theme	water	747:751	arg1	angle					761:765	water contact angle	747:765	water contact angle	747:765	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	6	24	theme	cell	934:937	arg1	application					939:949	solar cell application	928:949	solar cell application	928:949	The prepared TW showed 80 % total transmittance and 30-60 % haze, suitable for solar cell application.
33910716	2	25	from	pores	227:231	arg1	TW					236:237	TW	236:237	TW	236:237	However, it is necessary to fill pores in TW with natural substances to prepare all-biobased TW.
33910716	5	26	theme	crystallinity	726:738	arg1	morphologies					712:723	the morphologies	708:723	the morphologies	708:723	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	5	26	theme	crystallinity	726:738	arg1	index					740:744	crystallinity index	726:744	crystallinity index	726:744	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	4	27	theme	acetic	516:521	arg1	acid					523:526	acetic acid	516:526	acetic acid	516:526	CNF was isolated by combining the chemical and physical methods, and CTS was dissolved in acetic acid, and they were infiltrated into the pores of the bleached Fir veneer wood using a vacuum jar.
33910716	5	28	theme	CNF	626:628	arg1	effects					643:649	The CNF and chitosan effects	622:649	effects	643:649	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	6	29	dep	%	907:907	arg1	haze					909:912	haze	909:912	30-60 % haze	901:912	The prepared TW showed 80 % total transmittance and 30-60 % haze, suitable for solar cell application.
33910716	2	30	theme	all-biobased	274:285	arg1	TW					287:288	all-biobased TW	274:288	all-biobased TW	274:288	However, it is necessary to fill pores in TW with natural substances to prepare all-biobased TW.
33910716	5	31	theme	thermal	781:787	arg1	morphologies					712:723	the morphologies	708:723	the morphologies	708:723	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	5	31	theme	thermal	781:787	arg1	degradation					789:799	thermal degradation	781:799	thermal degradation	781:799	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	8	32	theme	CTS-TW	1102:1107	arg1	property					1086:1093	The antioxidant property	1070:1093	The antioxidant property of the CTS-TW	1070:1107	The antioxidant property of the CTS-TW significantly increased as compared to the original wood.
33910716	9	33	dep	showed	1178:1183	arg1	improved					1253:1260	improved	1253:1260	showed considerable tensile strength and yield strength of more than 200 % improved from the original wood	1178:1283	The CNF-TW showed considerable tensile strength and yield strength of more than 200 % improved from the original wood.
33910716	4	34	theme	bleached	577:584	arg1	wood					597:600	the bleached Fir veneer wood	573:600	the bleached Fir veneer wood using a vacuum jar	573:619	CNF was isolated by combining the chemical and physical methods, and CTS was dissolved in acetic acid, and they were infiltrated into the pores of the bleached Fir veneer wood using a vacuum jar.
33910716	3	35	theme	bleached	411:418	arg1	wood					420:423	the bleached wood	407:423	the bleached wood	407:423	This paper reports an all-biobased TW by infiltrating cellulose nanofiber (CNF) and chitosan (CTS) suspensions into the bleached wood.
33910716	0	36	theme	new	33:35	arg1	approach					37:44	A new approach	31:44	A new approach	31:44	All-biobased transparent-wood: A new approach and its environmental-friendly packaging application.
33910716	9	37	theme	%	1251:1251	arg1	strength					1206:1213	considerable tensile strength	1185:1213	considerable tensile strength	1185:1213	The CNF-TW showed considerable tensile strength and yield strength of more than 200 % improved from the original wood.
33910716	9	37	theme	%	1251:1251	arg1	strength					1225:1232	yield strength	1219:1232	yield strength	1219:1232	The CNF-TW showed considerable tensile strength and yield strength of more than 200 % improved from the original wood.
33910716	5	38	theme	chitosan	634:641	arg1	effects					643:649	The CNF and chitosan effects	622:649	effects	643:649	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	5	39	from	effects	643:649	arg1	properties					669:678	the mechanical properties	654:678	the mechanical properties of the TW	654:688	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	5	40	theme	contact	753:759	arg1	morphologies					712:723	the morphologies	708:723	the morphologies	708:723	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	5	40	theme	contact	753:759	arg1	angle					761:765	water contact angle	747:765	water contact angle	747:765	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	7	41	theme	UV	1029:1030	arg1	property					1042:1049	excellent UV shielding property	1019:1049	excellent UV shielding property	1019:1049	The all-biobased TW showed good thermal stability up to 315 °C and excellent UV shielding property for UV-B and UV-C.
33910716	6	42	theme	prepared	853:860	arg1	TW					862:863	The prepared TW	849:863	The prepared TW	849:863	The prepared TW showed 80 % total transmittance and 30-60 % haze, suitable for solar cell application.
33910716	0	43	theme	environmental-friendly	54:75	arg1	application					87:97	its environmental-friendly packaging application	50:97	its environmental-friendly packaging application	50:97	All-biobased transparent-wood: A new approach and its environmental-friendly packaging application.
33910716	5	44	theme	UV-shielding	806:817	arg1	properties					819:828	UV-shielding properties	806:828	UV-shielding properties	806:828	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	5	44	theme	UV-shielding	806:817	arg1	morphologies					712:723	the morphologies	708:723	the morphologies	708:723	The CNF and chitosan effects on the mechanical properties of the TW were studied, and the morphologies, crystallinity index, water contact angle, antioxidant, thermal degradation, and UV-shielding properties were investigated.
33910716	7	45	theme	shielding	1032:1040	arg1	property					1042:1049	excellent UV shielding property	1019:1049	excellent UV shielding property	1019:1049	The all-biobased TW showed good thermal stability up to 315 °C and excellent UV shielding property for UV-B and UV-C.
33910716	10	46	theme	a	1375:1375	arg1	bag					1377:1379	a bag	1375:1379	a bag	1375:1379	The potential for environment-friendly packaging applications was demonstrated by making a bag, medicine packaging, and straw for a drink.
33910716	10	47	theme	packaging	1325:1333	arg1	applications					1335:1346	environment-friendly packaging applications	1304:1346	environment-friendly packaging applications	1304:1346	The potential for environment-friendly packaging applications was demonstrated by making a bag, medicine packaging, and straw for a drink.
33910716	1	48	theme	emerging	128:135	arg1	Transparent-wood					100:115	Transparent-wood	100:115	Transparent-wood (TW)	100:120	Transparent-wood (TW) is an emerging research topic that can be applied to biobased products.
33910716	1	48	theme	emerging	128:135	arg1	topic					146:150	an emerging research topic	125:150	an emerging research topic that can be applied to biobased products	125:191	Transparent-wood (TW) is an emerging research topic that can be applied to biobased products.
33910716	9	49	theme	original	1271:1278	arg1	wood					1280:1283	the original wood	1267:1283	the original wood	1267:1283	The CNF-TW showed considerable tensile strength and yield strength of more than 200 % improved from the original wood.
33910716	1	50	theme	research	137:144	arg1	Transparent-wood					100:115	Transparent-wood	100:115	Transparent-wood (TW)	100:120	Transparent-wood (TW) is an emerging research topic that can be applied to biobased products.
33910716	1	50	theme	research	137:144	arg1	topic					146:150	an emerging research topic	125:150	an emerging research topic that can be applied to biobased products	125:191	Transparent-wood (TW) is an emerging research topic that can be applied to biobased products.
33910716	6	51	theme	suitable	915:922	arg1	%					875:875	80 %	872:875	80 % total transmittance	872:895	The prepared TW showed 80 % total transmittance and 30-60 % haze, suitable for solar cell application.
33910716	0	52	theme	packaging	77:85	arg1	application					87:97	its environmental-friendly packaging application	50:97	its environmental-friendly packaging application	50:97	All-biobased transparent-wood: A new approach and its environmental-friendly packaging application.
33910716	6	53	theme	solar	928:932	arg1	application					939:949	solar cell application	928:949	solar cell application	928:949	The prepared TW showed 80 % total transmittance and 30-60 % haze, suitable for solar cell application.
33910716	0	54	dep	transparent-wood	13:28	arg1	application					87:97	its environmental-friendly packaging application	50:97	its environmental-friendly packaging application	50:97	All-biobased transparent-wood: A new approach and its environmental-friendly packaging application.
33910716	0	54	dep	transparent-wood	13:28	arg1	approach					37:44	A new approach	31:44	A new approach	31:44	All-biobased transparent-wood: A new approach and its environmental-friendly packaging application.
33910716	4	55	theme	vacuum	610:615	arg1	jar					617:619	a vacuum jar	608:619	a vacuum jar	608:619	CNF was isolated by combining the chemical and physical methods, and CTS was dissolved in acetic acid, and they were infiltrated into the pores of the bleached Fir veneer wood using a vacuum jar.
33910716	9	56	theme	considerable	1185:1196	arg1	strength					1206:1213	considerable tensile strength	1185:1213	considerable tensile strength	1185:1213	The CNF-TW showed considerable tensile strength and yield strength of more than 200 % improved from the original wood.
33910716	3	57	theme	all-biobased	313:324	arg1	TW					326:327	an all-biobased TW	310:327	an all-biobased TW	310:327	This paper reports an all-biobased TW by infiltrating cellulose nanofiber (CNF) and chitosan (CTS) suspensions into the bleached wood.
33910716	4	58	theme	chemical	460:467	arg1	methods					482:488	the chemical and physical methods	456:488	the chemical and physical methods	456:488	CNF was isolated by combining the chemical and physical methods, and CTS was dissolved in acetic acid, and they were infiltrated into the pores of the bleached Fir veneer wood using a vacuum jar.
33357896	1	0	theme	film	348:351	arg1	gellan					333:338	gellan	333:338	gellan gum (G) film	333:351	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	1	1	theme	multiple	168:175	arg1	antibacterial					210:222	antibacterial	210:222	antibacterial	210:222	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	1	1	theme	multiple	168:175	arg1	pH					241:242	colorimetric pH	228:242	colorimetric pH	228:242	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	1	1	theme	multiple	168:175	arg1	antioxidant					197:207	antioxidant	197:207	antioxidant	197:207	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	1	1	theme	multiple	168:175	arg1	functions					177:185	multiple functions	168:185	multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties	168:263	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	4	2	theme	swelling	678:685	arg1	capacity					687:694	the swelling capacity	674:694	the swelling capacity of G/HSPI composite film and controlled the anthocyanins release	674:759	G film blended with HSPI greatly reduced the swelling capacity of G/HSPI composite film and controlled the anthocyanins release at pH greater than 6.0.
33357896	1	3	theme	Clitoria	297:304	arg1	extract					320:326	Clitoria ternatea (CT) extract	297:326	Clitoria ternatea (CT) extract	297:326	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	0	4	theme	food	108:111	arg1	freshness					113:121	food freshness	108:121	food freshness	108:121	Active and intelligent gellan gum-based packaging films for controlling anthocyanins release and monitoring food freshness.
33357896	5	5	theme	G	980:980	arg1	films					982:986	G films	980:986	G films	980:986	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	1	6	with	films	157:161	arg1	antibacterial					210:222	antibacterial	210:222	antibacterial	210:222	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	1	6	with	films	157:161	arg1	pH					241:242	colorimetric pH	228:242	colorimetric pH	228:242	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	1	6	with	films	157:161	arg1	antioxidant					197:207	antioxidant	197:207	antioxidant	197:207	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	1	6	with	films	157:161	arg1	functions					177:185	multiple functions	168:185	multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties	168:263	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	1	7	theme	ternatea	306:313	arg1	extract					320:326	Clitoria ternatea (CT) extract	297:326	Clitoria ternatea (CT) extract	297:326	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	5	8	mod	modified	948:955	arg3	addition					960:967	addition	960:967	addition of HSPI to G films	960:986	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	5	8	mod	modified	948:955	arg1	properties					813:822	The physical and mechanical properties	785:822	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength	785:922	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	6	9	theme	seafood	1182:1188	arg1	freshness					1190:1198	seafood freshness	1182:1198	seafood freshness	1182:1198	The smart films changed their color with the increase of total volatile basic nitrogen (TVBN) values during progressive spoilage of shrimp, revealing their potential application for monitoring seafood freshness.
33357896	4	10	theme	release	753:759	arg1	capacity					687:694	the swelling capacity	674:694	the swelling capacity of G/HSPI composite film and controlled the anthocyanins release	674:759	G film blended with HSPI greatly reduced the swelling capacity of G/HSPI composite film and controlled the anthocyanins release at pH greater than 6.0.
33357896	3	11	theme	soy	492:494	arg1	HSPI					513:516	HSPI	513:516	HSPI	513:516	Heat-treated soy protein isolate (HSPI) was able to interact with G and CT anthocyanins through the formation of electrostatic forces and covalent bonds.
33357896	3	11	theme	soy	492:494	arg1	isolate					504:510	Heat-treated soy protein isolate	479:510	Heat-treated soy protein isolate (HSPI)	479:517	Heat-treated soy protein isolate (HSPI) was able to interact with G and CT anthocyanins through the formation of electrostatic forces and covalent bonds.
33357896	3	12	theme	protein	496:502	arg1	HSPI					513:516	HSPI	513:516	HSPI	513:516	Heat-treated soy protein isolate (HSPI) was able to interact with G and CT anthocyanins through the formation of electrostatic forces and covalent bonds.
33357896	3	12	theme	protein	496:502	arg1	isolate					504:510	Heat-treated soy protein isolate	479:510	Heat-treated soy protein isolate (HSPI)	479:517	Heat-treated soy protein isolate (HSPI) was able to interact with G and CT anthocyanins through the formation of electrostatic forces and covalent bonds.
33357896	6	13	theme	nitrogen	1067:1074	arg1	values					1083:1088	total volatile basic nitrogen (TVBN) values	1046:1088	total volatile basic nitrogen (TVBN) values	1046:1088	The smart films changed their color with the increase of total volatile basic nitrogen (TVBN) values during progressive spoilage of shrimp, revealing their potential application for monitoring seafood freshness.
33357896	5	14	theme	G	827:827	arg1	films					829:833	G films	827:833	G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength	827:922	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	5	14	theme	G	827:827	arg1	hydrophobicity					843:856	hydrophobicity	843:856	hydrophobicity	843:856	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	5	14	theme	G	827:827	arg1	permeability					871:882	water vapor permeability	859:882	water vapor permeability	859:882	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	5	14	theme	G	827:827	arg1	capacity					894:901	swelling capacity	885:901	swelling capacity	885:901	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	5	14	theme	G	827:827	arg1	strength					915:922	tensile strength	907:922	tensile strength	907:922	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	5	15	theme	tensile	907:913	arg1	strength					915:922	tensile strength	907:922	tensile strength	907:922	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	6	16	theme	volatile	1052:1059	arg1	values					1083:1088	total volatile basic nitrogen (TVBN) values	1046:1088	total volatile basic nitrogen (TVBN) values	1046:1088	The smart films changed their color with the increase of total volatile basic nitrogen (TVBN) values during progressive spoilage of shrimp, revealing their potential application for monitoring seafood freshness.
33357896	6	17	theme	values	1083:1088	arg1	increase					1034:1041	the increase	1030:1041	the increase of total volatile basic nitrogen (TVBN) values	1030:1088	The smart films changed their color with the increase of total volatile basic nitrogen (TVBN) values during progressive spoilage of shrimp, revealing their potential application for monitoring seafood freshness.
33357896	5	18	theme	HSPI	972:975	arg1	addition					960:967	addition	960:967	addition of HSPI to G films	960:986	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	6	19	theme	basic	1061:1065	arg1	values					1083:1088	total volatile basic nitrogen (TVBN) values	1046:1088	total volatile basic nitrogen (TVBN) values	1046:1088	The smart films changed their color with the increase of total volatile basic nitrogen (TVBN) values during progressive spoilage of shrimp, revealing their potential application for monitoring seafood freshness.
33357896	6	20	theme	total	1046:1050	arg1	values					1083:1088	total volatile basic nitrogen (TVBN) values	1046:1088	total volatile basic nitrogen (TVBN) values	1046:1088	The smart films changed their color with the increase of total volatile basic nitrogen (TVBN) values during progressive spoilage of shrimp, revealing their potential application for monitoring seafood freshness.
33357896	5	21	theme	physical	789:796	arg1	properties					813:822	The physical and mechanical properties	785:822	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength	785:922	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	4	22	theme	controlled	725:734	arg1	release					753:759	controlled the anthocyanins release	725:759	controlled the anthocyanins release	725:759	G film blended with HSPI greatly reduced the swelling capacity of G/HSPI composite film and controlled the anthocyanins release at pH greater than 6.0.
33357896	2	23	theme	anthocyanins	385:396	arg1	stability					369:377	the stability	365:377	the stability of CT anthocyanins	365:396	G enhanced the stability of CT anthocyanins and allowed the anthocyanins to release from G film in a pH-responsive behavior.
33357896	0	24	theme	Active	0:5	arg1	gellan					23:28	Active and intelligent gellan	0:28	Active and intelligent gellan	0:28	Active and intelligent gellan gum-based packaging films for controlling anthocyanins release and monitoring food freshness.
33357896	1	25	theme	CT	316:317	arg1	extract					320:326	Clitoria ternatea (CT) extract	297:326	Clitoria ternatea (CT) extract	297:326	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	4	26	theme	composite	706:714	arg1	film					716:719	G/HSPI composite film	699:719	G/HSPI composite film	699:719	G film blended with HSPI greatly reduced the swelling capacity of G/HSPI composite film and controlled the anthocyanins release at pH greater than 6.0.
33357896	6	27	theme	shrimp	1121:1126	arg1	spoilage					1109:1116	progressive spoilage	1097:1116	progressive spoilage of shrimp	1097:1126	The smart films changed their color with the increase of total volatile basic nitrogen (TVBN) values during progressive spoilage of shrimp, revealing their potential application for monitoring seafood freshness.
33357896	2	28	theme	CT	382:383	arg1	anthocyanins					385:396	CT anthocyanins	382:396	CT anthocyanins	382:396	G enhanced the stability of CT anthocyanins and allowed the anthocyanins to release from G film in a pH-responsive behavior.
33357896	2	29	theme	G	443:443	arg1	film					445:448	G film	443:448	G film	443:448	G enhanced the stability of CT anthocyanins and allowed the anthocyanins to release from G film in a pH-responsive behavior.
33357896	4	30	theme	anthocyanins	740:751	arg1	release					753:759	controlled the anthocyanins release	725:759	controlled the anthocyanins release	725:759	G film blended with HSPI greatly reduced the swelling capacity of G/HSPI composite film and controlled the anthocyanins release at pH greater than 6.0.
33357896	0	31	theme	intelligent	11:21	arg1	gellan					23:28	Active and intelligent gellan	0:28	Active and intelligent gellan	0:28	Active and intelligent gellan gum-based packaging films for controlling anthocyanins release and monitoring food freshness.
33357896	5	32	theme	swelling	885:892	arg1	capacity					894:901	swelling capacity	885:901	swelling capacity	885:901	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	1	33	theme	colorimetric	228:239	arg1	pH					241:242	colorimetric pH	228:242	colorimetric pH	228:242	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	0	34	theme	packaging	40:48	arg1	films					50:54	packaging films	40:54	packaging films for controlling anthocyanins release and monitoring food freshness	40:121	Active and intelligent gellan gum-based packaging films for controlling anthocyanins release and monitoring food freshness.
33357896	5	35	theme	water	859:863	arg1	permeability					871:882	water vapor permeability	859:882	water vapor permeability	859:882	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	5	36	theme	films	829:833	arg1	properties					813:822	The physical and mechanical properties	785:822	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength	785:922	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	3	37	theme	bonds	626:630	arg1	formation					579:587	the formation	575:587	the formation of electrostatic forces and covalent bonds	575:630	Heat-treated soy protein isolate (HSPI) was able to interact with G and CT anthocyanins through the formation of electrostatic forces and covalent bonds.
33357896	5	38	theme	mechanical	802:811	arg1	properties					813:822	The physical and mechanical properties	785:822	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength	785:922	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	1	39	theme	indicator	244:252	arg1	properties					254:263	indicator properties	244:263	indicator properties	244:263	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	2	40	theme	pH-responsive	455:467	arg1	behavior					469:476	a pH-responsive behavior	453:476	a pH-responsive behavior	453:476	G enhanced the stability of CT anthocyanins and allowed the anthocyanins to release from G film in a pH-responsive behavior.
33357896	5	41	theme	vapor	865:869	arg1	permeability					871:882	water vapor permeability	859:882	water vapor permeability	859:882	The physical and mechanical properties of G films such as hydrophobicity, water vapor permeability, swelling capacity and tensile strength were also significantly modified by addition of HSPI to G films.
33357896	6	42	theme	TVBN	1077:1080	arg1	values					1083:1088	total volatile basic nitrogen (TVBN) values	1046:1088	total volatile basic nitrogen (TVBN) values	1046:1088	The smart films changed their color with the increase of total volatile basic nitrogen (TVBN) values during progressive spoilage of shrimp, revealing their potential application for monitoring seafood freshness.
33357896	1	43	theme	Active	124:129	arg1	films					157:161	Active and intelligent packaging films	124:161	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties	124:263	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	6	44	theme	potential	1145:1153	arg1	application					1155:1165	their potential application	1139:1165	their potential application for monitoring seafood freshness	1139:1198	The smart films changed their color with the increase of total volatile basic nitrogen (TVBN) values during progressive spoilage of shrimp, revealing their potential application for monitoring seafood freshness.
33357896	6	45	with	color	1019:1023	arg1	increase					1034:1041	the increase	1030:1041	the increase of total volatile basic nitrogen (TVBN) values	1030:1088	The smart films changed their color with the increase of total volatile basic nitrogen (TVBN) values during progressive spoilage of shrimp, revealing their potential application for monitoring seafood freshness.
33357896	1	46	dep	antioxidant	197:207	arg1	properties					254:263	indicator properties	244:263	indicator properties	244:263	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	4	47	theme	film	716:719	arg1	capacity					687:694	the swelling capacity	674:694	the swelling capacity of G/HSPI composite film and controlled the anthocyanins release	674:759	G film blended with HSPI greatly reduced the swelling capacity of G/HSPI composite film and controlled the anthocyanins release at pH greater than 6.0.
33357896	4	48	theme	G/HSPI	699:704	arg1	film					716:719	G/HSPI composite film	699:719	G/HSPI composite film	699:719	G film blended with HSPI greatly reduced the swelling capacity of G/HSPI composite film and controlled the anthocyanins release at pH greater than 6.0.
33357896	1	49	theme	intelligent	135:145	arg1	films					157:161	Active and intelligent packaging films	124:161	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties	124:263	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	3	50	theme	covalent	617:624	arg1	bonds					626:630	covalent bonds	617:630	covalent bonds	617:630	Heat-treated soy protein isolate (HSPI) was able to interact with G and CT anthocyanins through the formation of electrostatic forces and covalent bonds.
33357896	1	51	theme	packaging	147:155	arg1	films					157:161	Active and intelligent packaging films	124:161	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties	124:263	Active and intelligent packaging films with multiple functions including antioxidant, antibacterial and colorimetric pH indicator properties were developed by incorporating Clitoria ternatea (CT) extract into gellan gum (G) film.
33357896	6	52	theme	progressive	1097:1107	arg1	spoilage					1109:1116	progressive spoilage	1097:1116	progressive spoilage of shrimp	1097:1126	The smart films changed their color with the increase of total volatile basic nitrogen (TVBN) values during progressive spoilage of shrimp, revealing their potential application for monitoring seafood freshness.
33357896	3	53	theme	Heat-treated	479:490	arg1	HSPI					513:516	HSPI	513:516	HSPI	513:516	Heat-treated soy protein isolate (HSPI) was able to interact with G and CT anthocyanins through the formation of electrostatic forces and covalent bonds.
33357896	3	53	theme	Heat-treated	479:490	arg1	isolate					504:510	Heat-treated soy protein isolate	479:510	Heat-treated soy protein isolate (HSPI)	479:517	Heat-treated soy protein isolate (HSPI) was able to interact with G and CT anthocyanins through the formation of electrostatic forces and covalent bonds.
33357896	0	54	theme	anthocyanins	72:83	arg1	release					85:91	anthocyanins release	72:91	anthocyanins release	72:91	Active and intelligent gellan gum-based packaging films for controlling anthocyanins release and monitoring food freshness.
33357896	4	55	theme	G	633:633	arg1	film					635:638	G film	633:638	G film blended with HSPI	633:656	G film blended with HSPI greatly reduced the swelling capacity of G/HSPI composite film and controlled the anthocyanins release at pH greater than 6.0.
33357896	3	56	theme	electrostatic	592:604	arg1	forces					606:611	electrostatic forces	592:611	electrostatic forces	592:611	Heat-treated soy protein isolate (HSPI) was able to interact with G and CT anthocyanins through the formation of electrostatic forces and covalent bonds.
33357896	3	57	dep	G	545:545	arg1	anthocyanins					554:565	anthocyanins	554:565	anthocyanins	554:565	Heat-treated soy protein isolate (HSPI) was able to interact with G and CT anthocyanins through the formation of electrostatic forces and covalent bonds.
33357896	6	58	theme	smart	993:997	arg1	films					999:1003	The smart films	989:1003	The smart films	989:1003	The smart films changed their color with the increase of total volatile basic nitrogen (TVBN) values during progressive spoilage of shrimp, revealing their potential application for monitoring seafood freshness.
33357896	3	59	theme	forces	606:611	arg1	formation					579:587	the formation	575:587	the formation of electrostatic forces and covalent bonds	575:630	Heat-treated soy protein isolate (HSPI) was able to interact with G and CT anthocyanins through the formation of electrostatic forces and covalent bonds.
32526356	7	0	theme	arginine	1375:1382	arg1	citrate					1384:1390	arginine citrate	1375:1390	arginine citrate	1375:1390	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	0	theme	arginine	1375:1382	arg1	buffer					1308:1313	histidine buffer	1298:1313	histidine buffer	1298:1313	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	6	1	theme	sample	1176:1181	arg1	preparation					1183:1193	sample preparation	1176:1193	sample preparation	1176:1193	Method 2 works best taking sample preparation and accuracy into account.
32526356	9	2	dep	methodology	1672:1682	arg1	we					1684:1685	we	1684:1685	we	1684:1685	The methodology we developed is broadly applicable for the analysis of the composition of maximally freeze concentrated solutions and can help to elucidate protein stability during lyophilisation.
32526356	2	3	theme	process	350:356	arg1	stability					358:366	the process stability	346:366	the process stability of biopharmaceuticals	346:388	Understanding the composition of the maximally freeze concentrated solution can help to judge the process stability of biopharmaceuticals during lyophilisation.
32526356	8	4	theme	%	1580:1580	arg1	content					1564:1570	a water content	1556:1570	a water content of 20-30%	1556:1580	The freeze concentrates exhibited a water content of 20-30%, slightly dependent on the excipients, but independent of the antibody concentration.
32526356	1	5	theme	freezing	237:244	arg1	step					246:249	the freezing step	233:249	the freezing step	233:249	During freeze-drying of a liquid formulation, a freeze-concentrate is formed in the first phase, the freezing step.
32526356	1	5	theme	freezing	237:244	arg1	phase					226:230	the first phase	216:230	the first phase	216:230	During freeze-drying of a liquid formulation, a freeze-concentrate is formed in the first phase, the freezing step.
32526356	7	6	theme	arginine	1351:1358	arg1	hydrochloride					1360:1372	arginine hydrochloride	1351:1372	arginine hydrochloride	1351:1372	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	6	theme	arginine	1351:1358	arg1	buffer					1308:1313	histidine buffer	1298:1313	histidine buffer	1298:1313	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	3	7	theme	concentrated	515:526	arg1	solution					528:535	the maximally freeze concentrated solution	494:535	the maximally freeze concentrated solution	494:535	Our objective was to develop a suitable method to determine the water content of the maximally freeze concentrated solution using differential scanning calorimetry (DSC).
32526356	4	8	theme	different	590:598	arg1	methods					600:606	Three different methods	584:606	Three different methods	584:606	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	5	9	theme	high	1058:1061	arg1	number					1063:1068	a high number	1056:1068	a high number of samples	1056:1079	While Method 1 is accurate but requires the analysis of a high number of samples, Method 3 requires only one single sample, with a loss of accuracy.
32526356	7	10	theme	phosphate	1316:1324	arg1	buffer					1308:1313	histidine buffer	1298:1313	histidine buffer	1298:1313	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	10	theme	phosphate	1316:1324	arg1	buffer					1326:1331	phosphate buffer	1316:1331	phosphate buffer	1316:1331	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	4	11	theme	transition	654:663	arg1	temperature					665:675	the glass transition temperature	644:675	the glass transition temperature of the	644:682	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	0	12	theme	concentrated	77:88	arg1	solution					90:97	concentrated solution	77:97	concentrated solution suitable for protein lyophilisation	77:133	Method development and analysis of the water content of the maximally freeze concentrated solution suitable for protein lyophilisation.
32526356	4	13	theme	concentrated	701:712	arg1	Tg					723:724	concentrated solution Tg'	701:725	concentrated solution Tg'	701:725	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	14	theme	concentration	909:921	arg1	series					923:928	a concentration series	907:928	a concentration series	907:928	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	6	15	dep	works	1158:1162	arg1	taking					1169:1174	taking	1169:1174	works best taking sample preparation and accuracy into account	1158:1219	Method 2 works best taking sample preparation and accuracy into account.
32526356	4	16	theme	melting	820:826	arg1	enthalpy					828:835	the melting enthalpy	816:835	the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series	816:928	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	17	theme	melting	735:741	arg1	Tm					755:756	the melting temperature Tm	731:756	the melting temperature Tm	731:756	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	3	18	theme	differential	543:554	arg1	calorimetry					565:575	differential scanning calorimetry	543:575	differential scanning calorimetry (DSC)	543:581	Our objective was to develop a suitable method to determine the water content of the maximally freeze concentrated solution using differential scanning calorimetry (DSC).
32526356	3	18	theme	differential	543:554	arg1	DSC					578:580	DSC	578:580	DSC	578:580	Our objective was to develop a suitable method to determine the water content of the maximally freeze concentrated solution using differential scanning calorimetry (DSC).
32526356	4	19	dep	determination	953:965	arg1	iii					936:938	iii	936:938	iii	936:938	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	1	20	theme	formulation	169:179	arg1	freeze-drying					143:155	freeze-drying	143:155	freeze-drying of a liquid formulation	143:179	During freeze-drying of a liquid formulation, a freeze-concentrate is formed in the first phase, the freezing step.
32526356	0	21	theme	suitable	99:106	arg1	solution					90:97	concentrated solution	77:97	concentrated solution suitable for protein lyophilisation	77:133	Method development and analysis of the water content of the maximally freeze concentrated solution suitable for protein lyophilisation.
32526356	7	22	theme	concentrated	1499:1510	arg1	solution					1512:1519	the maximally freeze concentrated solution	1478:1519	the maximally freeze concentrated solution	1478:1519	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	3	23	theme	scanning	556:563	arg1	calorimetry					565:575	differential scanning calorimetry	543:575	differential scanning calorimetry (DSC)	543:581	Our objective was to develop a suitable method to determine the water content of the maximally freeze concentrated solution using differential scanning calorimetry (DSC).
32526356	3	23	theme	scanning	556:563	arg1	DSC					578:580	DSC	578:580	DSC	578:580	Our objective was to develop a suitable method to determine the water content of the maximally freeze concentrated solution using differential scanning calorimetry (DSC).
32526356	9	24	theme	protein	1824:1830	arg1	stability					1832:1840	protein stability	1824:1840	protein stability	1824:1840	The methodology we developed is broadly applicable for the analysis of the composition of maximally freeze concentrated solutions and can help to elucidate protein stability during lyophilisation.
32526356	4	25	theme	glass	648:652	arg1	temperature					665:675	the glass transition temperature	644:675	the glass transition temperature of the	644:682	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	7	26	theme	sodium	1334:1339	arg1	chloride					1341:1348	sodium chloride	1334:1348	sodium chloride	1334:1348	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	26	theme	sodium	1334:1339	arg1	buffer					1308:1313	histidine buffer	1298:1313	histidine buffer	1298:1313	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	2	27	theme	solution	319:326	arg1	composition					270:280	the composition	266:280	the composition of the maximally freeze concentrated solution	266:326	Understanding the composition of the maximally freeze concentrated solution can help to judge the process stability of biopharmaceuticals during lyophilisation.
32526356	0	28	theme	Method	0:5	arg1	development					7:17	Method development	0:17	Method development	0:17	Method development and analysis of the water content of the maximally freeze concentrated solution suitable for protein lyophilisation.
32526356	4	29	theme	enthalpy	828:835	arg1	regression					802:811	the linear regression	791:811	(ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series	786:928	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	29	theme	enthalpy	828:835	arg1	determination					953:965	a one-point determination	941:965	(iii) a one-point determination of the amount of unfrozen water	935:997	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	29	theme	enthalpy	828:835	arg1	series					778:783	a concentration series	762:783	a concentration series	762:783	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	2	30	theme	concentrated	306:317	arg1	solution					319:326	the maximally freeze concentrated solution	285:326	the maximally freeze concentrated solution	285:326	Understanding the composition of the maximally freeze concentrated solution can help to judge the process stability of biopharmaceuticals during lyophilisation.
32526356	2	31	theme	biopharmaceuticals	371:388	arg1	stability					358:366	the process stability	346:366	the process stability of biopharmaceuticals	346:388	Understanding the composition of the maximally freeze concentrated solution can help to judge the process stability of biopharmaceuticals during lyophilisation.
32526356	4	32	theme	amount	974:979	arg1	regression					802:811	the linear regression	791:811	(ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series	786:928	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	32	theme	amount	974:979	arg1	determination					953:965	a one-point determination	941:965	(iii) a one-point determination of the amount of unfrozen water	935:997	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	32	theme	amount	974:979	arg1	series					778:783	a concentration series	762:783	a concentration series	762:783	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	7	33	dep	sugar	1249:1253	arg1	trehalose					1265:1273	trehalose	1265:1273	trehalose	1265:1273	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	33	dep	sugar	1249:1253	arg1	sucrose					1256:1262	sucrose	1256:1262	sucrose	1256:1262	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	34	theme	other	1280:1284	arg1	excipients					1286:1295	other excipients	1280:1295	other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate)	1280:1391	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	9	35	theme	solutions	1788:1796	arg1	composition					1743:1753	the composition	1739:1753	the composition of maximally freeze concentrated solutions	1739:1796	The methodology we developed is broadly applicable for the analysis of the composition of maximally freeze concentrated solutions and can help to elucidate protein stability during lyophilisation.
32526356	9	36	theme	composition	1743:1753	arg1	analysis					1727:1734	the analysis	1723:1734	the analysis of the composition of maximally freeze concentrated solutions	1723:1796	The methodology we developed is broadly applicable for the analysis of the composition of maximally freeze concentrated solutions and can help to elucidate protein stability during lyophilisation.
32526356	7	37	theme	histidine	1298:1306	arg1	chloride					1341:1348	sodium chloride	1334:1348	sodium chloride	1334:1348	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	37	theme	histidine	1298:1306	arg1	hydrochloride					1360:1372	arginine hydrochloride	1351:1372	arginine hydrochloride	1351:1372	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	37	theme	histidine	1298:1306	arg1	citrate					1384:1390	arginine citrate	1375:1390	arginine citrate	1375:1390	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	37	theme	histidine	1298:1306	arg1	buffer					1308:1313	histidine buffer	1298:1313	histidine buffer	1298:1313	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	37	theme	histidine	1298:1306	arg1	buffer					1326:1331	phosphate buffer	1316:1331	phosphate buffer	1316:1331	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	0	38	theme	protein	112:118	arg1	lyophilisation					120:133	protein lyophilisation	112:133	protein lyophilisation	112:133	Method development and analysis of the water content of the maximally freeze concentrated solution suitable for protein lyophilisation.
32526356	7	39	theme	antibody	1423:1430	arg1	concentrations					1432:1445	different antibody concentrations	1413:1445	different antibody concentrations	1413:1445	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	1	40	theme	liquid	162:167	arg1	formulation					169:179	a liquid formulation	160:179	a liquid formulation	160:179	During freeze-drying of a liquid formulation, a freeze-concentrate is formed in the first phase, the freezing step.
32526356	3	41	theme	water	477:481	arg1	content					483:489	the water content	473:489	the water content of the maximally freeze concentrated solution	473:535	Our objective was to develop a suitable method to determine the water content of the maximally freeze concentrated solution using differential scanning calorimetry (DSC).
32526356	4	42	theme	melting	889:895	arg1	event					897:901	the melting event	885:901	the melting event for a concentration series	885:928	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	43	theme	linear	795:800	arg1	regression					802:811	the linear regression	791:811	(ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series	786:928	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	3	44	theme	suitable	444:451	arg1	method					453:458	a suitable method	442:458	a suitable method to determine the water content of the maximally freeze concentrated solution using differential scanning calorimetry (DSC)	442:581	Our objective was to develop a suitable method to determine the water content of the maximally freeze concentrated solution using differential scanning calorimetry (DSC).
32526356	5	45	theme	number	1063:1068	arg1	analysis					1044:1051	the analysis	1040:1051	the analysis of a high number of samples	1040:1079	While Method 1 is accurate but requires the analysis of a high number of samples, Method 3 requires only one single sample, with a loss of accuracy.
32526356	5	46	theme	single	1109:1114	arg1	sample					1116:1121	only one single sample	1100:1121	only one single sample	1100:1121	While Method 1 is accurate but requires the analysis of a high number of samples, Method 3 requires only one single sample, with a loss of accuracy.
32526356	7	47	theme	Various	1222:1228	arg1	systems					1230:1236	Various systems	1222:1236	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate)	1222:1391	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	8	48	theme	concentration	1653:1665	arg1	independent					1625:1635	independent	1625:1635	independent	1625:1635	The freeze concentrates exhibited a water content of 20-30%, slightly dependent on the excipients, but independent of the antibody concentration.
32526356	0	49	theme	content	45:51	arg1	analysis					23:30	analysis	23:30	analysis of the water content of the	23:58	Method development and analysis of the water content of the maximally freeze concentrated solution suitable for protein lyophilisation.
32526356	0	49	theme	content	45:51	arg1	development					7:17	Method development	0:17	Method development	0:17	Method development and analysis of the water content of the maximally freeze concentrated solution suitable for protein lyophilisation.
32526356	7	50	theme	different	1413:1421	arg1	concentrations					1432:1445	different antibody concentrations	1413:1445	different antibody concentrations	1413:1445	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	8	51	theme	antibody	1644:1651	arg1	concentration					1653:1665	the antibody concentration	1640:1665	the antibody concentration	1640:1665	The freeze concentrates exhibited a water content of 20-30%, slightly dependent on the excipients, but independent of the antibody concentration.
32526356	0	52	theme	water	39:43	arg1	content					45:51	the water content	35:51	the water content of the	35:58	Method development and analysis of the water content of the maximally freeze concentrated solution suitable for protein lyophilisation.
32526356	5	53	theme	samples	1073:1079	arg1	number					1063:1068	a high number	1056:1068	a high number of samples	1056:1079	While Method 1 is accurate but requires the analysis of a high number of samples, Method 3 requires only one single sample, with a loss of accuracy.
32526356	4	54	theme	Tg	864:865	arg1	onset					855:859	the onset	851:859	the onset of Tg'	851:866	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	55	dep	regression	802:811	arg1	ii					787:788	ii	787:788	ii	787:788	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	56	dep	the	627:629	arg1	i					624:624	i	624:624	i	624:624	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	56	dep	the	627:629	arg1	intercept					631:639	intercept	631:639	intercept	631:639	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	57	theme	solution	714:721	arg1	Tg					723:724	concentrated solution Tg'	701:725	concentrated solution Tg'	701:725	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	7	58	theme	solution	1512:1519	arg1	composition					1463:1473	the composition	1459:1473	the composition of the maximally freeze concentrated solution	1459:1519	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	8	59	theme	freeze	1526:1531	arg1	concentrates					1533:1544	The freeze concentrates	1522:1544	The freeze concentrates	1522:1544	The freeze concentrates exhibited a water content of 20-30%, slightly dependent on the excipients, but independent of the antibody concentration.
32526356	8	60	theme	water	1558:1562	arg1	content					1564:1570	a water content	1556:1570	a water content of 20-30%	1556:1580	The freeze concentrates exhibited a water content of 20-30%, slightly dependent on the excipients, but independent of the antibody concentration.
32526356	1	61	theme	first	220:224	arg1	step					246:249	the freezing step	233:249	the freezing step	233:249	During freeze-drying of a liquid formulation, a freeze-concentrate is formed in the first phase, the freezing step.
32526356	1	61	theme	first	220:224	arg1	phase					226:230	the first phase	216:230	the first phase	216:230	During freeze-drying of a liquid formulation, a freeze-concentrate is formed in the first phase, the freezing step.
32526356	4	62	theme	concentration	764:776	arg1	series					778:783	a concentration series	762:783	a concentration series	762:783	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	63	theme	temperature	743:753	arg1	Tm					755:756	the melting temperature Tm	731:756	the melting temperature Tm	731:756	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	7	64	dep	excipients	1286:1295	arg1	chloride					1341:1348	sodium chloride	1334:1348	sodium chloride	1334:1348	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	64	dep	excipients	1286:1295	arg1	hydrochloride					1360:1372	arginine hydrochloride	1351:1372	arginine hydrochloride	1351:1372	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	64	dep	excipients	1286:1295	arg1	citrate					1384:1390	arginine citrate	1375:1390	arginine citrate	1375:1390	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	64	dep	excipients	1286:1295	arg1	buffer					1308:1313	histidine buffer	1298:1313	histidine buffer	1298:1313	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	64	dep	excipients	1286:1295	arg1	buffer					1326:1331	phosphate buffer	1316:1331	phosphate buffer	1316:1331	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	9	65	theme	freeze	1768:1773	arg1	solutions					1788:1796	maximally freeze concentrated solutions	1758:1796	maximally freeze concentrated solutions	1758:1796	The methodology we developed is broadly applicable for the analysis of the composition of maximally freeze concentrated solutions and can help to elucidate protein stability during lyophilisation.
32526356	7	66	contain	containing	1238:1247	arg2	excipients					1286:1295	other excipients	1280:1295	other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate)	1280:1391	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	66	contain	containing	1238:1247	arg2	sugar					1249:1253	sugar	1249:1253	sugar (sucrose, trehalose)	1249:1274	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	7	66	contain	containing	1238:1247	arg1	systems					1230:1236	Various systems	1222:1236	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate)	1222:1391	Various systems containing sugar (sucrose, trehalose) and other excipients (histidine buffer, phosphate buffer, sodium chloride, arginine hydrochloride, arginine citrate) were evaluated with different antibody concentrations to evaluate the composition of the maximally freeze concentrated solution.
32526356	0	67	theme	the	56:58	arg1	content					45:51	the water content	35:51	the water content of the	35:58	Method development and analysis of the water content of the maximally freeze concentrated solution suitable for protein lyophilisation.
32526356	4	68	theme	water	993:997	arg1	water					993:997	unfrozen water	984:997	unfrozen water	984:997	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	68	theme	water	993:997	arg1	amount					974:979	the amount	970:979	the amount of unfrozen water	970:997	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	5	69	theme	accuracy	1139:1146	arg1	loss					1131:1134	a loss	1129:1134	a loss of accuracy	1129:1146	While Method 1 is accurate but requires the analysis of a high number of samples, Method 3 requires only one single sample, with a loss of accuracy.
32526356	3	70	theme	solution	528:535	arg1	content					483:489	the water content	473:489	the water content of the maximally freeze concentrated solution	473:535	Our objective was to develop a suitable method to determine the water content of the maximally freeze concentrated solution using differential scanning calorimetry (DSC).
32526356	9	71	theme	concentrated	1775:1786	arg1	solutions					1788:1796	maximally freeze concentrated solutions	1758:1796	maximally freeze concentrated solutions	1758:1796	The methodology we developed is broadly applicable for the analysis of the composition of maximally freeze concentrated solutions and can help to elucidate protein stability during lyophilisation.
32526356	4	72	theme	one-point	943:951	arg1	determination					953:965	a one-point determination	941:965	(iii) a one-point determination of the amount of unfrozen water	935:997	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	73	theme	the	680:682	arg1	temperature					665:675	the glass transition temperature	644:675	the glass transition temperature of the	644:682	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	74	theme	unfrozen	984:991	arg1	water					993:997	unfrozen water	984:997	unfrozen water	984:997	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
32526356	4	75	theme	event	897:901	arg1	end					878:880	the end	874:880	the end of the melting event for a concentration series	874:928	Three different methods were compared: (i) the intercept of the glass transition temperature of the maximally freeze concentrated solution Tg' and the melting temperature Tm for a concentration series, (ii) the linear regression of the melting enthalpy starting from the onset of Tg' until the end of the melting event for a concentration series, and (iii) a one-point determination of the amount of unfrozen water.
33647689	0	0	theme	physicochemical	67:81	arg1	properties					83:92	physicochemical properties	67:92	physicochemical properties	67:92	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	5	1	theme	treated	1094:1100	arg1	counterparts					1102:1113	the dry-heat treated counterparts	1081:1113	the dry-heat treated counterparts	1081:1113	Moreover, the V-type diffraction peak intensity and resistance to in vitro enzymatic hydrolysis of samples treated with moist-heat were increased to a greater extent than the dry-heat treated counterparts.
33647689	3	2	dep	process	729:735	arg1	variance					698:705	variance	698:705	variance	698:705	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	4	3	theme	moist-heat	853:862	arg1	WS-LA					872:876	moist-heat treated WS-LA	853:876	moist-heat treated WS-LA	853:876	Additionally, high resistance to thermal decomposition and a lower 1022/995 cm-1 absorbance ratio were observed in moist-heat treated WS-LA compared with dry-heat samples.
33647689	4	4	theme	treated	864:870	arg1	WS-LA					872:876	moist-heat treated WS-LA	853:876	moist-heat treated WS-LA	853:876	Additionally, high resistance to thermal decomposition and a lower 1022/995 cm-1 absorbance ratio were observed in moist-heat treated WS-LA compared with dry-heat samples.
33647689	4	5	theme	absorbance	819:828	arg1	ratio					830:834	a lower 1022/995 cm-1 absorbance ratio	797:834	a lower 1022/995 cm-1 absorbance ratio	797:834	Additionally, high resistance to thermal decomposition and a lower 1022/995 cm-1 absorbance ratio were observed in moist-heat treated WS-LA compared with dry-heat samples.
33647689	3	6	dep	revealed	519:526	arg1	finding					678:684	the finding	674:684	the finding which is at variance to dry-heat treatment process	674:735	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	5	7	theme	in	976:977	arg1	hydrolysis					995:1004	in vitro enzymatic hydrolysis	976:1004	in vitro enzymatic hydrolysis	976:1004	Moreover, the V-type diffraction peak intensity and resistance to in vitro enzymatic hydrolysis of samples treated with moist-heat were increased to a greater extent than the dry-heat treated counterparts.
33647689	0	8	from	Effect	0:5	arg1	digestibility					108:120	in vitro digestibility	99:120	in vitro digestibility	99:120	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	0	8	from	Effect	0:5	arg1	properties					83:92	physicochemical properties	67:92	physicochemical properties	67:92	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	0	8	from	Effect	0:5	arg1	structure					56:64	structure	56:64	structure	56:64	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	3	9	theme	treatment	719:727	arg1	process					729:735	dry-heat treatment process	710:735	dry-heat treatment process	710:735	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	0	10	dep	in	99:100	arg1	vitro					102:106	vitro	102:106	vitro	102:106	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	1	11	theme	dry	232:234	arg1	processes					276:284	moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes	199:284	moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes	199:284	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	5	12	theme	greater	1061:1067	arg1	extent					1069:1074	a greater extent	1059:1074	a greater extent than the dry-heat treated counterparts	1059:1113	Moreover, the V-type diffraction peak intensity and resistance to in vitro enzymatic hydrolysis of samples treated with moist-heat were increased to a greater extent than the dry-heat treated counterparts.
33647689	6	13	theme	functional	1171:1180	arg1	complexes					1195:1203	functional starch-lipid complexes	1171:1203	functional starch-lipid complexes	1171:1203	In sum, this study would facilitate the application of functional starch-lipid complexes in food necessitated heat treatments.
33647689	5	14	theme	diffraction	931:941	arg1	intensity					948:956	the V-type diffraction peak intensity	920:956	the V-type diffraction peak intensity	920:956	Moreover, the V-type diffraction peak intensity and resistance to in vitro enzymatic hydrolysis of samples treated with moist-heat were increased to a greater extent than the dry-heat treated counterparts.
33647689	0	15	theme	in	99:100	arg1	digestibility					108:120	in vitro digestibility	99:120	in vitro digestibility	99:120	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	6	16	from	application	1156:1166	arg1	treatments					1231:1240	food necessitated heat treatments	1208:1240	food necessitated heat treatments	1208:1240	In sum, this study would facilitate the application of functional starch-lipid complexes in food necessitated heat treatments.
33647689	5	17	theme	peak	943:946	arg1	intensity					948:956	the V-type diffraction peak intensity	920:956	the V-type diffraction peak intensity	920:956	Moreover, the V-type diffraction peak intensity and resistance to in vitro enzymatic hydrolysis of samples treated with moist-heat were increased to a greater extent than the dry-heat treated counterparts.
33647689	6	18	theme	heat	1226:1229	arg1	treatments					1231:1240	food necessitated heat treatments	1208:1240	food necessitated heat treatments	1208:1240	In sum, this study would facilitate the application of functional starch-lipid complexes in food necessitated heat treatments.
33647689	0	19	theme	processes	39:47	arg1	Effect					0:5	Effect	0:5	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.	0:159	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	1	20	theme	wheat	337:341	arg1	WS					351:352	WS	351:352	WS	351:352	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	1	20	theme	wheat	337:341	arg1	starch					343:348	wheat starch	337:348	wheat starch (WS) supplemented with lauric acid (LA)	337:388	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	5	21	theme	dry-heat	1085:1092	arg1	counterparts					1102:1113	the dry-heat treated counterparts	1081:1113	the dry-heat treated counterparts	1081:1113	Moreover, the V-type diffraction peak intensity and resistance to in vitro enzymatic hydrolysis of samples treated with moist-heat were increased to a greater extent than the dry-heat treated counterparts.
33647689	2	22	theme	Elemental	391:399	arg1	analysis					413:420	Elemental composition analysis	391:420	Elemental composition analysis	391:420	Elemental composition analysis revealed the interplay between WS and LA.
33647689	1	23	theme	starch	343:348	arg1	structure					293:301	structure	293:301	structure	293:301	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	1	23	theme	starch	343:348	arg1	properties					323:332	physicochemical properties	307:332	physicochemical properties	307:332	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	4	24	theme	1022/995 cm-1	805:817	arg1	ratio					830:834	a lower 1022/995 cm-1 absorbance ratio	797:834	a lower 1022/995 cm-1 absorbance ratio	797:834	Additionally, high resistance to thermal decomposition and a lower 1022/995 cm-1 absorbance ratio were observed in moist-heat treated WS-LA compared with dry-heat samples.
33647689	6	25	theme	food	1208:1211	arg1	treatments					1231:1240	food necessitated heat treatments	1208:1240	food necessitated heat treatments	1208:1240	In sum, this study would facilitate the application of functional starch-lipid complexes in food necessitated heat treatments.
33647689	4	26	theme	lower	799:803	arg1	ratio					830:834	a lower 1022/995 cm-1 absorbance ratio	797:834	a lower 1022/995 cm-1 absorbance ratio	797:834	Additionally, high resistance to thermal decomposition and a lower 1022/995 cm-1 absorbance ratio were observed in moist-heat treated WS-LA compared with dry-heat samples.
33647689	5	27	theme	samples	1009:1015	arg1	resistance					962:971	resistance	962:971	resistance to in vitro enzymatic hydrolysis	962:1004	Moreover, the V-type diffraction peak intensity and resistance to in vitro enzymatic hydrolysis of samples treated with moist-heat were increased to a greater extent than the dry-heat treated counterparts.
33647689	5	27	theme	samples	1009:1015	arg1	intensity					948:956	the V-type diffraction peak intensity	920:956	the V-type diffraction peak intensity	920:956	Moreover, the V-type diffraction peak intensity and resistance to in vitro enzymatic hydrolysis of samples treated with moist-heat were increased to a greater extent than the dry-heat treated counterparts.
33647689	4	28	theme	thermal	771:777	arg1	decomposition					779:791	thermal decomposition	771:791	thermal decomposition	771:791	Additionally, high resistance to thermal decomposition and a lower 1022/995 cm-1 absorbance ratio were observed in moist-heat treated WS-LA compared with dry-heat samples.
33647689	0	29	dep	structure	56:64	arg1	the					52:54	the	52:54	the	52:54	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	6	30	theme	necessitated	1213:1224	arg1	treatments					1231:1240	food necessitated heat treatments	1208:1240	food necessitated heat treatments	1208:1240	In sum, this study would facilitate the application of functional starch-lipid complexes in food necessitated heat treatments.
33647689	5	31	theme	V-type	924:929	arg1	intensity					948:956	the V-type diffraction peak intensity	920:956	the V-type diffraction peak intensity	920:956	Moreover, the V-type diffraction peak intensity and resistance to in vitro enzymatic hydrolysis of samples treated with moist-heat were increased to a greater extent than the dry-heat treated counterparts.
33647689	0	32	theme	moist	10:14	arg1	processes					39:47	moist and dry-heat treatment processes	10:47	moist and dry-heat treatment processes	10:47	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	3	33	theme	moist-heat	602:611	arg1	treatment					613:621	moist-heat treatment	602:621	moist-heat treatment (relative to samples without any heat treatments)	602:671	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	3	34	theme	iodine	503:508	arg1	staining					510:517	iodine staining	503:517	iodine staining	503:517	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	5	35	dep	in	976:977	arg1	vitro					979:983	vitro	979:983	vitro	979:983	Moreover, the V-type diffraction peak intensity and resistance to in vitro enzymatic hydrolysis of samples treated with moist-heat were increased to a greater extent than the dry-heat treated counterparts.
33647689	0	36	theme	treatment	29:37	arg1	processes					39:47	moist and dry-heat treatment processes	10:47	moist and dry-heat treatment processes	10:47	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	1	37	dep	structure	293:301	arg1	the					289:291	the	289:291	the	289:291	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	0	38	theme	wheat	125:129	arg1	complexes					150:158	wheat starch-lauric acid complexes	125:158	wheat starch-lauric acid complexes	125:158	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	3	39	theme	crystalline	542:552	arg1	structure					554:562	lamellar crystalline structure	533:562	lamellar crystalline structure of WS-LA complexes	533:581	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	0	40	theme	dry-heat	20:27	arg1	processes					39:47	moist and dry-heat treatment processes	10:47	moist and dry-heat treatment processes	10:47	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	1	41	theme	-heat	260:264	arg1	processes					276:284	moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes	199:284	moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes	199:284	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	4	42	theme	dry-heat	892:899	arg1	samples					901:907	dry-heat samples	892:907	dry-heat samples	892:907	Additionally, high resistance to thermal decomposition and a lower 1022/995 cm-1 absorbance ratio were observed in moist-heat treated WS-LA compared with dry-heat samples.
33647689	5	43	theme	enzymatic	985:993	arg1	hydrolysis					995:1004	in vitro enzymatic hydrolysis	976:1004	in vitro enzymatic hydrolysis	976:1004	Moreover, the V-type diffraction peak intensity and resistance to in vitro enzymatic hydrolysis of samples treated with moist-heat were increased to a greater extent than the dry-heat treated counterparts.
33647689	1	44	theme	moist	199:203	arg1	processes					276:284	moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes	199:284	moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes	199:284	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	1	45	theme	treatment	266:274	arg1	processes					276:284	moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes	199:284	moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes	199:284	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	0	46	theme	acid	145:148	arg1	complexes					150:158	wheat starch-lauric acid complexes	125:158	wheat starch-lauric acid complexes	125:158	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	1	47	theme	physicochemical	307:321	arg1	properties					323:332	physicochemical properties	307:332	physicochemical properties	307:332	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	1	48	theme	processes	276:284	arg1	impact					189:194	the impact	185:194	the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA)	185:388	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	0	49	theme	starch-lauric	131:143	arg1	complexes					150:158	wheat starch-lauric acid complexes	125:158	wheat starch-lauric acid complexes	125:158	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	2	50	theme	composition	401:411	arg1	analysis					413:420	Elemental composition analysis	391:420	Elemental composition analysis	391:420	Elemental composition analysis revealed the interplay between WS and LA.
33647689	3	51	theme	lamellar	533:540	arg1	structure					554:562	lamellar crystalline structure	533:562	lamellar crystalline structure of WS-LA complexes	533:581	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	6	52	theme	complexes	1195:1203	arg1	application					1156:1166	the application	1152:1166	the application of functional starch-lipid complexes in food necessitated heat treatments	1152:1240	In sum, this study would facilitate the application of functional starch-lipid complexes in food necessitated heat treatments.
33647689	3	53	theme	dry-heat	710:717	arg1	process					729:735	dry-heat treatment process	710:735	dry-heat treatment process	710:735	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	1	54	theme	lauric	373:378	arg1	LA					386:387	LA	386:387	LA	386:387	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	1	54	theme	lauric	373:378	arg1	acid					380:383	lauric acid	373:383	lauric acid (LA)	373:388	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	3	55	theme	complexes	573:581	arg1	structure					554:562	lamellar crystalline structure	533:562	lamellar crystalline structure of WS-LA complexes	533:581	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	1	56	from	impact	189:194	arg1	structure					293:301	structure	293:301	structure	293:301	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	1	56	from	impact	189:194	arg1	properties					323:332	physicochemical properties	307:332	physicochemical properties	307:332	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	0	57	theme	complexes	150:158	arg1	structure					56:64	structure	56:64	structure	56:64	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	0	57	theme	complexes	150:158	arg1	properties					83:92	physicochemical properties	67:92	physicochemical properties	67:92	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	0	57	theme	complexes	150:158	arg1	digestibility					108:120	in vitro digestibility	99:120	in vitro digestibility	99:120	Effect of moist and dry-heat treatment processes on the structure, physicochemical properties, and in vitro digestibility of wheat starch-lauric acid complexes.
33647689	6	58	theme	starch-lipid	1182:1193	arg1	complexes					1195:1203	functional starch-lipid complexes	1171:1203	functional starch-lipid complexes	1171:1203	In sum, this study would facilitate the application of functional starch-lipid complexes in food necessitated heat treatments.
33647689	1	59	dep	moist	199:203	arg1	microwaving					248:258	microwaving	248:258	microwaving	248:258	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	1	59	dep	moist	199:203	arg1	baking					237:242	baking	237:242	baking	237:242	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	1	59	dep	moist	199:203	arg1	boiling					219:225	boiling	219:225	boiling	219:225	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	1	59	dep	moist	199:203	arg1	steaming					206:213	steaming	206:213	steaming	206:213	Herein, we investigated the impact of moist (steaming and boiling) and dry (baking and microwaving)-heat treatment processes on the structure and physicochemical properties of wheat starch (WS) supplemented with lauric acid (LA).
33647689	4	60	theme	high	752:755	arg1	resistance					757:766	high resistance	752:766	high resistance to thermal decomposition	752:791	Additionally, high resistance to thermal decomposition and a lower 1022/995 cm-1 absorbance ratio were observed in moist-heat treated WS-LA compared with dry-heat samples.
33647689	3	61	theme	Scanning	464:471	arg1	SEM					494:496	SEM	494:496	SEM	494:496	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	3	61	theme	Scanning	464:471	arg1	microscopy					482:491	Scanning electron microscopy	464:491	Scanning electron microscopy (SEM)	464:497	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	4	62	located	observed	841:848	arg2	ratio					830:834	a lower 1022/995 cm-1 absorbance ratio	797:834	a lower 1022/995 cm-1 absorbance ratio	797:834	Additionally, high resistance to thermal decomposition and a lower 1022/995 cm-1 absorbance ratio were observed in moist-heat treated WS-LA compared with dry-heat samples.
33647689	4	62	located	observed	841:848	arg1	WS-LA					872:876	moist-heat treated WS-LA	853:876	moist-heat treated WS-LA	853:876	Additionally, high resistance to thermal decomposition and a lower 1022/995 cm-1 absorbance ratio were observed in moist-heat treated WS-LA compared with dry-heat samples.
33647689	4	62	located	observed	841:848	arg2	resistance					757:766	high resistance	752:766	high resistance to thermal decomposition	752:791	Additionally, high resistance to thermal decomposition and a lower 1022/995 cm-1 absorbance ratio were observed in moist-heat treated WS-LA compared with dry-heat samples.
33647689	3	63	theme	heat	656:659	arg1	treatments					661:670	any heat treatments	652:670	any heat treatments	652:670	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	3	64	theme	WS-LA	567:571	arg1	complexes					573:581	WS-LA complexes	567:581	WS-LA complexes	567:581	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	3	65	theme	electron	473:480	arg1	SEM					494:496	SEM	494:496	SEM	494:496	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	3	65	theme	electron	473:480	arg1	microscopy					482:491	Scanning electron microscopy	464:491	Scanning electron microscopy (SEM)	464:497	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33647689	3	66	dep	treatment	613:621	arg1	relative					624:631	relative	624:631	relative	624:631	Scanning electron microscopy (SEM) and iodine staining revealed that lamellar crystalline structure of WS-LA complexes was improved after moist-heat treatment (relative to samples without any heat treatments); the finding which is at variance to dry-heat treatment process.
33741368	8	0	theme	Huh-7	1067:1071	arg1	cells					1073:1077	Huh-7 cells	1067:1077	Huh-7 cells	1067:1077	The anticancer assay in vitro exhibited that SSWP could effectively inhibit 48.9% of Huh-7 cells growth at 50 μg/mL and arrest cells at S-phase, and induce tumor cells apoptosis.
33741368	4	1	theme	homogenous	495:504	arg1	one					506:508	a homogenous one	493:508	a homogenous one with a molecular weight of 21.5 kDa	493:544	The obtained SSWP was a homogenous one with a molecular weight of 21.5 kDa according to the high-performance gel permeation chromatography.
33741368	4	1	theme	homogenous	495:504	arg1	SSWP					484:487	The obtained SSWP	471:487	The obtained SSWP	471:487	The obtained SSWP was a homogenous one with a molecular weight of 21.5 kDa according to the high-performance gel permeation chromatography.
33741368	6	2	theme	methylation	728:738	arg1	analysis					740:747	The methylation analysis	724:747	The methylation analysis	724:747	The methylation analysis showed that SSWP consists mainly of Araf-(1→, →5)-Araf-(1→, →3,5)-Araf-(1→, →4)-Galp-(1→, →4)-Glcp-(1→.
33741368	8	3	theme	cells	1073:1077	arg1	%					1062:1062	48.9%	1058:1062	48.9% of Huh-7 cells growth	1058:1084	The anticancer assay in vitro exhibited that SSWP could effectively inhibit 48.9% of Huh-7 cells growth at 50 μg/mL and arrest cells at S-phase, and induce tumor cells apoptosis.
33741368	8	3	theme	cells	1073:1077	arg1	cells					1073:1077	Huh-7 cells	1067:1077	Huh-7 cells	1067:1077	The anticancer assay in vitro exhibited that SSWP could effectively inhibit 48.9% of Huh-7 cells growth at 50 μg/mL and arrest cells at S-phase, and induce tumor cells apoptosis.
33741368	4	4	theme	permeation	584:593	arg1	chromatography					595:608	the high-performance gel permeation chromatography	559:608	the high-performance gel permeation chromatography	559:608	The obtained SSWP was a homogenous one with a molecular weight of 21.5 kDa according to the high-performance gel permeation chromatography.
33741368	9	5	theme	sarmentosum	1194:1204	arg1	Bunge					1206:1210	S. sarmentosum Bunge	1191:1210	S. sarmentosum Bunge	1191:1210	Together, polysaccharide from S. sarmentosum Bunge could be a potential natural antitumor agent.
33741368	6	6	theme	-Araf-	814:819	arg1	1→					849:850	Araf-(1→, →5)-Araf-(1→, →3,5)-Araf-(1→, →4)-Galp-(1→, →4)-Glcp-(1→	785:850	1→	849:850	The methylation analysis showed that SSWP consists mainly of Araf-(1→, →5)-Araf-(1→, →3,5)-Araf-(1→, →4)-Galp-(1→, →4)-Glcp-(1→.
33741368	2	7	from	structures	311:320	arg1	plant					351:355	this plant	346:355	this plant	346:355	The purpose of this study was to explore the chemical structures of polysaccharides from this plant.
33741368	4	8	theme	gel	580:582	arg1	chromatography					595:608	the high-performance gel permeation chromatography	559:608	the high-performance gel permeation chromatography	559:608	The obtained SSWP was a homogenous one with a molecular weight of 21.5 kDa according to the high-performance gel permeation chromatography.
33741368	0	9	theme	hepatocellular	106:119	arg1	cells					131:135	hepatocellular carcinoma cells	106:135	hepatocellular carcinoma cells	106:135	Structure elucidation of arabinogalactoglucan isolated from Sedum sarmentosum Bunge and its inhibition on hepatocellular carcinoma cells in vitro.
33741368	5	10	theme	major	615:619	arg1	arabinose					660:668	arabinose	660:668	arabinose	660:668	The major monosaccharide composition of SSWP was arabinose, glucose and galactose in a molar ratio of 2.4:1:1.8.
33741368	5	10	theme	major	615:619	arg1	composition					636:646	The major monosaccharide composition	611:646	The major monosaccharide composition of SSWP	611:654	The major monosaccharide composition of SSWP was arabinose, glucose and galactose in a molar ratio of 2.4:1:1.8.
33741368	3	11	theme	neutral	360:366	arg1	SSWP					384:387	SSWP	384:387	SSWP	384:387	A neutral polysaccharide (SSWP) was isolated and purified by ion-exchange chromatography and Superdex-75 column.
33741368	3	11	theme	neutral	360:366	arg1	polysaccharide					368:381	A neutral polysaccharide	358:381	A neutral polysaccharide (SSWP)	358:388	A neutral polysaccharide (SSWP) was isolated and purified by ion-exchange chromatography and Superdex-75 column.
33741368	5	12	theme	monosaccharide	621:634	arg1	arabinose					660:668	arabinose	660:668	arabinose	660:668	The major monosaccharide composition of SSWP was arabinose, glucose and galactose in a molar ratio of 2.4:1:1.8.
33741368	5	12	theme	monosaccharide	621:634	arg1	composition					636:646	The major monosaccharide composition	611:646	The major monosaccharide composition of SSWP	611:654	The major monosaccharide composition of SSWP was arabinose, glucose and galactose in a molar ratio of 2.4:1:1.8.
33741368	1	13	dep	Sedum	147:151	arg1	sarmentosum					153:163	sarmentosum	153:163	sarmentosum	153:163	Sedum sarmentosum Bunge (SS) is clinically used as Chinese medicine for hepatitis related diseases treatment.
33741368	4	14	theme	obtained	475:482	arg1	one					506:508	a homogenous one	493:508	a homogenous one with a molecular weight of 21.5 kDa	493:544	The obtained SSWP was a homogenous one with a molecular weight of 21.5 kDa according to the high-performance gel permeation chromatography.
33741368	4	14	theme	obtained	475:482	arg1	SSWP					484:487	The obtained SSWP	471:487	The obtained SSWP	471:487	The obtained SSWP was a homogenous one with a molecular weight of 21.5 kDa according to the high-performance gel permeation chromatography.
33741368	7	15	theme	NMR	857:859	arg1	result					861:866	The NMR result	853:866	The NMR result	853:866	The NMR result and enzymatic digestion data comprehensively indicated that SSWP was a novel arabinogalactoglucan-type structure.
33741368	2	16	theme	study	277:281	arg1	purpose					261:267	The purpose	257:267	The purpose of this study	257:281	The purpose of this study was to explore the chemical structures of polysaccharides from this plant.
33741368	8	17	theme	cells	1144:1148	arg1	apoptosis					1150:1158	tumor cells apoptosis	1138:1158	tumor cells apoptosis	1138:1158	The anticancer assay in vitro exhibited that SSWP could effectively inhibit 48.9% of Huh-7 cells growth at 50 μg/mL and arrest cells at S-phase, and induce tumor cells apoptosis.
33741368	0	18	theme	carcinoma	121:129	arg1	cells					131:135	hepatocellular carcinoma cells	106:135	hepatocellular carcinoma cells	106:135	Structure elucidation of arabinogalactoglucan isolated from Sedum sarmentosum Bunge and its inhibition on hepatocellular carcinoma cells in vitro.
33741368	9	19	theme	potential	1223:1231	arg1	polysaccharide					1171:1184	polysaccharide	1171:1184	polysaccharide from S. sarmentosum Bunge	1171:1210	Together, polysaccharide from S. sarmentosum Bunge could be a potential natural antitumor agent.
33741368	9	19	theme	potential	1223:1231	arg1	agent					1251:1255	a potential natural antitumor agent	1221:1255	a potential natural antitumor agent	1221:1255	Together, polysaccharide from S. sarmentosum Bunge could be a potential natural antitumor agent.
33741368	5	20	theme	SSWP	651:654	arg1	arabinose					660:668	arabinose	660:668	arabinose	660:668	The major monosaccharide composition of SSWP was arabinose, glucose and galactose in a molar ratio of 2.4:1:1.8.
33741368	5	20	theme	SSWP	651:654	arg1	composition					636:646	The major monosaccharide composition	611:646	The major monosaccharide composition of SSWP	611:654	The major monosaccharide composition of SSWP was arabinose, glucose and galactose in a molar ratio of 2.4:1:1.8.
33741368	8	21	theme	tumor	1138:1142	arg1	apoptosis					1150:1158	tumor cells apoptosis	1138:1158	tumor cells apoptosis	1138:1158	The anticancer assay in vitro exhibited that SSWP could effectively inhibit 48.9% of Huh-7 cells growth at 50 μg/mL and arrest cells at S-phase, and induce tumor cells apoptosis.
33741368	9	22	theme	natural	1233:1239	arg1	polysaccharide					1171:1184	polysaccharide	1171:1184	polysaccharide from S. sarmentosum Bunge	1171:1210	Together, polysaccharide from S. sarmentosum Bunge could be a potential natural antitumor agent.
33741368	9	22	theme	natural	1233:1239	arg1	agent					1251:1255	a potential natural antitumor agent	1221:1255	a potential natural antitumor agent	1221:1255	Together, polysaccharide from S. sarmentosum Bunge could be a potential natural antitumor agent.
33741368	2	23	from	plant	351:355	arg1	polysaccharides					325:339	polysaccharides	325:339	polysaccharides from this plant	325:355	The purpose of this study was to explore the chemical structures of polysaccharides from this plant.
33741368	2	23	from	plant	351:355	arg1	structures					311:320	the chemical structures	298:320	the chemical structures of polysaccharides from this plant	298:355	The purpose of this study was to explore the chemical structures of polysaccharides from this plant.
33741368	6	24	theme	-Galp-	828:833	arg1	1→					849:850	Araf-(1→, →5)-Araf-(1→, →3,5)-Araf-(1→, →4)-Galp-(1→, →4)-Glcp-(1→	785:850	1→	849:850	The methylation analysis showed that SSWP consists mainly of Araf-(1→, →5)-Araf-(1→, →3,5)-Araf-(1→, →4)-Galp-(1→, →4)-Glcp-(1→.
33741368	0	25	theme	Structure	0:8	arg1	elucidation					10:20	Structure elucidation	0:20	Structure elucidation of arabinogalactoglucan	0:44	Structure elucidation of arabinogalactoglucan isolated from Sedum sarmentosum Bunge and its inhibition on hepatocellular carcinoma cells in vitro.
33741368	9	26	theme	antitumor	1241:1249	arg1	polysaccharide					1171:1184	polysaccharide	1171:1184	polysaccharide from S. sarmentosum Bunge	1171:1210	Together, polysaccharide from S. sarmentosum Bunge could be a potential natural antitumor agent.
33741368	9	26	theme	antitumor	1241:1249	arg1	agent					1251:1255	a potential natural antitumor agent	1221:1255	a potential natural antitumor agent	1221:1255	Together, polysaccharide from S. sarmentosum Bunge could be a potential natural antitumor agent.
33741368	8	27	theme	anticancer	986:995	arg1	assay					997:1001	The anticancer assay	982:1001	The anticancer assay in vitro	982:1010	The anticancer assay in vitro exhibited that SSWP could effectively inhibit 48.9% of Huh-7 cells growth at 50 μg/mL and arrest cells at S-phase, and induce tumor cells apoptosis.
33741368	2	28	theme	chemical	302:309	arg1	structures					311:320	the chemical structures	298:320	the chemical structures of polysaccharides from this plant	298:355	The purpose of this study was to explore the chemical structures of polysaccharides from this plant.
33741368	3	29	theme	ion-exchange	419:430	arg1	chromatography					432:445	ion-exchange chromatography	419:445	ion-exchange chromatography	419:445	A neutral polysaccharide (SSWP) was isolated and purified by ion-exchange chromatography and Superdex-75 column.
33741368	0	30	theme	arabinogalactoglucan	25:44	arg1	elucidation					10:20	Structure elucidation	0:20	Structure elucidation of arabinogalactoglucan	0:44	Structure elucidation of arabinogalactoglucan isolated from Sedum sarmentosum Bunge and its inhibition on hepatocellular carcinoma cells in vitro.
33741368	5	31	from	arabinose	660:668	arg1	ratio					704:708	a molar ratio	696:708	a molar ratio of 2.4:1:1.8	696:721	The major monosaccharide composition of SSWP was arabinose, glucose and galactose in a molar ratio of 2.4:1:1.8.
33741368	6	32	theme	Araf-	785:789	arg1	1→					849:850	Araf-(1→, →5)-Araf-(1→, →3,5)-Araf-(1→, →4)-Galp-(1→, →4)-Glcp-(1→	785:850	1→	849:850	The methylation analysis showed that SSWP consists mainly of Araf-(1→, →5)-Araf-(1→, →3,5)-Araf-(1→, →4)-Galp-(1→, →4)-Glcp-(1→.
33741368	4	33	theme	high-performance	563:578	arg1	chromatography					595:608	the high-performance gel permeation chromatography	559:608	the high-performance gel permeation chromatography	559:608	The obtained SSWP was a homogenous one with a molecular weight of 21.5 kDa according to the high-performance gel permeation chromatography.
33741368	5	34	theme	2.4:1:1.8	713:721	arg1	ratio					704:708	a molar ratio	696:708	a molar ratio of 2.4:1:1.8	696:721	The major monosaccharide composition of SSWP was arabinose, glucose and galactose in a molar ratio of 2.4:1:1.8.
33741368	0	35	from	inhibition	92:101	arg1	cells					131:135	hepatocellular carcinoma cells	106:135	hepatocellular carcinoma cells	106:135	Structure elucidation of arabinogalactoglucan isolated from Sedum sarmentosum Bunge and its inhibition on hepatocellular carcinoma cells in vitro.
33741368	1	36	theme	Chinese	198:204	arg1	Bunge					165:169	Sedum sarmentosum Bunge	147:169	Sedum sarmentosum Bunge (SS)	147:174	Sedum sarmentosum Bunge (SS) is clinically used as Chinese medicine for hepatitis related diseases treatment.
33741368	1	36	theme	Chinese	198:204	arg1	medicine					206:213	Chinese medicine	198:213	Chinese medicine	198:213	Sedum sarmentosum Bunge (SS) is clinically used as Chinese medicine for hepatitis related diseases treatment.
33741368	9	37	from	Bunge	1206:1210	arg1	polysaccharide					1171:1184	polysaccharide	1171:1184	polysaccharide from S. sarmentosum Bunge	1171:1210	Together, polysaccharide from S. sarmentosum Bunge could be a potential natural antitumor agent.
33741368	9	37	from	Bunge	1206:1210	arg1	agent					1251:1255	a potential natural antitumor agent	1221:1255	a potential natural antitumor agent	1221:1255	Together, polysaccharide from S. sarmentosum Bunge could be a potential natural antitumor agent.
33741368	3	38	theme	Superdex-75	451:461	arg1	column					463:468	Superdex-75 column	451:468	Superdex-75 column	451:468	A neutral polysaccharide (SSWP) was isolated and purified by ion-exchange chromatography and Superdex-75 column.
33741368	0	39	dep	Sedum	60:64	arg1	sarmentosum					66:76	sarmentosum	66:76	sarmentosum	66:76	Structure elucidation of arabinogalactoglucan isolated from Sedum sarmentosum Bunge and its inhibition on hepatocellular carcinoma cells in vitro.
33741368	6	40	theme	-Glcp-	842:847	arg1	1→					849:850	Araf-(1→, →5)-Araf-(1→, →3,5)-Araf-(1→, →4)-Galp-(1→, →4)-Glcp-(1→	785:850	1→	849:850	The methylation analysis showed that SSWP consists mainly of Araf-(1→, →5)-Araf-(1→, →3,5)-Araf-(1→, →4)-Galp-(1→, →4)-Glcp-(1→.
33741368	4	41	theme	molecular	517:525	arg1	weight					527:532	a molecular weight	515:532	a molecular weight of 21.5 kDa	515:544	The obtained SSWP was a homogenous one with a molecular weight of 21.5 kDa according to the high-performance gel permeation chromatography.
33741368	7	42	theme	arabinogalactoglucan-type	945:969	arg1	structure					971:979	a novel arabinogalactoglucan-type structure	937:979	a novel arabinogalactoglucan-type structure	937:979	The NMR result and enzymatic digestion data comprehensively indicated that SSWP was a novel arabinogalactoglucan-type structure.
33741368	7	42	theme	arabinogalactoglucan-type	945:969	arg1	SSWP					928:931	SSWP	928:931	SSWP	928:931	The NMR result and enzymatic digestion data comprehensively indicated that SSWP was a novel arabinogalactoglucan-type structure.
33741368	0	43	from	Bunge	78:82	arg1	cells					131:135	hepatocellular carcinoma cells	106:135	hepatocellular carcinoma cells	106:135	Structure elucidation of arabinogalactoglucan isolated from Sedum sarmentosum Bunge and its inhibition on hepatocellular carcinoma cells in vitro.
33741368	0	44	theme	Sedum	60:64	arg1	Bunge					78:82	Sedum sarmentosum Bunge	60:82	Sedum sarmentosum Bunge	60:82	Structure elucidation of arabinogalactoglucan isolated from Sedum sarmentosum Bunge and its inhibition on hepatocellular carcinoma cells in vitro.
33741368	4	45	theme	21.5 kDa	537:544	arg1	weight					527:532	a molecular weight	515:532	a molecular weight of 21.5 kDa	515:544	The obtained SSWP was a homogenous one with a molecular weight of 21.5 kDa according to the high-performance gel permeation chromatography.
33741368	5	46	from	glucose	671:677	arg1	ratio					704:708	a molar ratio	696:708	a molar ratio of 2.4:1:1.8	696:721	The major monosaccharide composition of SSWP was arabinose, glucose and galactose in a molar ratio of 2.4:1:1.8.
33741368	5	47	theme	molar	698:702	arg1	ratio					704:708	a molar ratio	696:708	a molar ratio of 2.4:1:1.8	696:721	The major monosaccharide composition of SSWP was arabinose, glucose and galactose in a molar ratio of 2.4:1:1.8.
33741368	1	48	used	used	190:193	arg2	SS					172:173	SS	172:173	SS	172:173	Sedum sarmentosum Bunge (SS) is clinically used as Chinese medicine for hepatitis related diseases treatment.
33741368	1	48	used	used	190:193	arg2	Bunge					165:169	Sedum sarmentosum Bunge	147:169	Sedum sarmentosum Bunge (SS)	147:174	Sedum sarmentosum Bunge (SS) is clinically used as Chinese medicine for hepatitis related diseases treatment.
33741368	1	48	used	used	190:193	arg2	medicine					206:213	Chinese medicine	198:213	Chinese medicine	198:213	Sedum sarmentosum Bunge (SS) is clinically used as Chinese medicine for hepatitis related diseases treatment.
33741368	6	49	theme	-Araf-	798:803	arg1	1→					849:850	Araf-(1→, →5)-Araf-(1→, →3,5)-Araf-(1→, →4)-Galp-(1→, →4)-Glcp-(1→	785:850	1→	849:850	The methylation analysis showed that SSWP consists mainly of Araf-(1→, →5)-Araf-(1→, →3,5)-Araf-(1→, →4)-Galp-(1→, →4)-Glcp-(1→.
33741368	2	50	theme	polysaccharides	325:339	arg1	structures					311:320	the chemical structures	298:320	the chemical structures of polysaccharides from this plant	298:355	The purpose of this study was to explore the chemical structures of polysaccharides from this plant.
33741368	1	51	theme	hepatitis	219:227	arg1	diseases					237:244	hepatitis related diseases	219:244	hepatitis related diseases treatment	219:254	Sedum sarmentosum Bunge (SS) is clinically used as Chinese medicine for hepatitis related diseases treatment.
33741368	7	52	theme	novel	939:943	arg1	structure					971:979	a novel arabinogalactoglucan-type structure	937:979	a novel arabinogalactoglucan-type structure	937:979	The NMR result and enzymatic digestion data comprehensively indicated that SSWP was a novel arabinogalactoglucan-type structure.
33741368	7	52	theme	novel	939:943	arg1	SSWP					928:931	SSWP	928:931	SSWP	928:931	The NMR result and enzymatic digestion data comprehensively indicated that SSWP was a novel arabinogalactoglucan-type structure.
33741368	4	53	with	one	506:508	arg1	weight					527:532	a molecular weight	515:532	a molecular weight of 21.5 kDa	515:544	The obtained SSWP was a homogenous one with a molecular weight of 21.5 kDa according to the high-performance gel permeation chromatography.
33741368	1	54	theme	Sedum	147:151	arg1	Bunge					165:169	Sedum sarmentosum Bunge	147:169	Sedum sarmentosum Bunge (SS)	147:174	Sedum sarmentosum Bunge (SS) is clinically used as Chinese medicine for hepatitis related diseases treatment.
33741368	1	54	theme	Sedum	147:151	arg1	medicine					206:213	Chinese medicine	198:213	Chinese medicine	198:213	Sedum sarmentosum Bunge (SS) is clinically used as Chinese medicine for hepatitis related diseases treatment.
33741368	1	54	theme	Sedum	147:151	arg1	SS					172:173	SS	172:173	SS	172:173	Sedum sarmentosum Bunge (SS) is clinically used as Chinese medicine for hepatitis related diseases treatment.
33741368	7	55	dep	result	861:866	arg1	data					892:895	data	892:895	data	892:895	The NMR result and enzymatic digestion data comprehensively indicated that SSWP was a novel arabinogalactoglucan-type structure.
33741368	1	56	theme	related	229:235	arg1	diseases					237:244	hepatitis related diseases	219:244	hepatitis related diseases treatment	219:254	Sedum sarmentosum Bunge (SS) is clinically used as Chinese medicine for hepatitis related diseases treatment.
33741368	8	57	theme	%	1062:1062	arg1	growth					1079:1084	48.9% of Huh-7 cells growth	1058:1084	48.9% of Huh-7 cells growth	1058:1084	The anticancer assay in vitro exhibited that SSWP could effectively inhibit 48.9% of Huh-7 cells growth at 50 μg/mL and arrest cells at S-phase, and induce tumor cells apoptosis.
33741368	1	58	theme	diseases	237:244	arg1	treatment					246:254	hepatitis related diseases treatment	219:254	hepatitis related diseases treatment	219:254	Sedum sarmentosum Bunge (SS) is clinically used as Chinese medicine for hepatitis related diseases treatment.
33741368	9	59	theme	S.	1191:1192	arg1	Bunge					1206:1210	S. sarmentosum Bunge	1191:1210	S. sarmentosum Bunge	1191:1210	Together, polysaccharide from S. sarmentosum Bunge could be a potential natural antitumor agent.
33741368	7	60	theme	enzymatic	872:880	arg1	digestion					882:890	enzymatic digestion	872:890	enzymatic digestion	872:890	The NMR result and enzymatic digestion data comprehensively indicated that SSWP was a novel arabinogalactoglucan-type structure.
33741368	5	61	from	galactose	683:691	arg1	ratio					704:708	a molar ratio	696:708	a molar ratio of 2.4:1:1.8	696:721	The major monosaccharide composition of SSWP was arabinose, glucose and galactose in a molar ratio of 2.4:1:1.8.
34323706	7	0	from	introduction	1076:1087	arg1	neutralization					1141:1154	charge neutralization	1134:1154	charge neutralization	1134:1154	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	7	0	from	introduction	1076:1087	arg1	FS-MC					1127:1131	FS-MC	1127:1131	FS-MC	1127:1131	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	7	0	from	introduction	1076:1087	arg1	interaction					1211:1221	hydrophobic interaction	1199:1221	hydrophobic interaction	1199:1221	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	7	0	from	introduction	1076:1087	arg1	action					1191:1196	compression double electric-layer action	1157:1196	compression double electric-layer action	1157:1196	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	5	1	with	compounds	838:846	arg1	weight					863:868	molecular weight > 10 kDa	853:877	molecular weight > 10 kDa	853:877	Furthermore, FS-MC exhibited an excellent behavior on the removal of organic compounds with molecular weight > 10 kDa, including long chain alkanes, cycloalkanes, and aromatic hydrocarbon compounds.
34323706	3	2	theme	wastewater	499:508	arg1	flocculation					510:521	The emulsified oily wastewater flocculation performance and mechanism	479:547	flocculation	510:521	The emulsified oily wastewater flocculation performance and mechanism by using FS-MC were evaluated and studied.
34323706	7	3	theme	compression	1157:1167	arg1	action					1191:1196	compression double electric-layer action	1157:1196	compression double electric-layer action	1157:1196	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	7	3	theme	compression	1157:1167	arg1	FS-MC					1127:1131	FS-MC	1127:1131	FS-MC	1127:1131	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	0	4	theme	composite	90:98	arg1	flocculant					109:118	composite magnetic flocculant	90:118	composite magnetic flocculant	90:118	Removal of emulsified oil from water by using recyclable chitosan based covalently bonded composite magnetic flocculant: Performance and mechanism.
34323706	0	5	from	Removal	0:6	arg1	water					31:35	water	31:35	water	31:35	Removal of emulsified oil from water by using recyclable chitosan based covalently bonded composite magnetic flocculant: Performance and mechanism.
34323706	8	6	theme	oil	1413:1415	arg1	rate					1425:1428	oil removal rate	1413:1428	oil removal rate	1413:1428	Recycling experiments also showed that no obvious decrease of oil removal rate was observed by using magnetic FS-MC flocculants in five cycles.
34323706	4	7	theme	2.0	723:725	arg1	dosages					712:718	dosages	712:718	dosages of 2.0, 2.5, and 2.0 mg/L, respectively	712:758	Results showed that 94.47%, 93.95%, and 92.98% of emulsified oil could be removed by using FS-MC1, FS-MC2 and FS-MC3 at dosages of 2.0, 2.5, and 2.0 mg/L, respectively.
34323706	8	8	from	flocculants	1467:1477	arg1	cycles					1487:1492	five cycles	1482:1492	five cycles	1482:1492	Recycling experiments also showed that no obvious decrease of oil removal rate was observed by using magnetic FS-MC flocculants in five cycles.
34323706	1	9	theme	silane	331:336	arg1	agent					347:351	a silane coupling agent	329:351	a silane coupling agent	329:351	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	5	10	theme	compounds	838:846	arg1	removal					819:825	the removal	815:825	the removal of organic compounds with molecular weight > 10 kDa, including long chain alkanes, cycloalkanes, and aromatic hydrocarbon compounds	815:957	Furthermore, FS-MC exhibited an excellent behavior on the removal of organic compounds with molecular weight > 10 kDa, including long chain alkanes, cycloalkanes, and aromatic hydrocarbon compounds.
34323706	1	11	theme	coupling	338:345	arg1	agent					347:351	a silane coupling agent	329:351	a silane coupling agent	329:351	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	7	12	theme	hydrophobic	1105:1115	arg1	groups					1117:1122	cationic and hydrophobic groups	1092:1122	cationic and hydrophobic groups	1092:1122	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	2	13	theme	core-shell	392:401	arg1	structure					403:411	the core-shell structure	388:411	the core-shell structure of FS-MC	388:420	The covalent bond Fe-O-Si-O-C and the core-shell structure of FS-MC were confirmed through several characterization methods.
34323706	4	14	theme	2.5	728:730	arg1	dosages					712:718	dosages	712:718	dosages of 2.0, 2.5, and 2.0 mg/L, respectively	712:758	Results showed that 94.47%, 93.95%, and 92.98% of emulsified oil could be removed by using FS-MC1, FS-MC2 and FS-MC3 at dosages of 2.0, 2.5, and 2.0 mg/L, respectively.
34323706	2	15	theme	covalent	358:365	arg1	Fe-O-Si-O-C					372:382	The covalent bond Fe-O-Si-O-C	354:382	The covalent bond Fe-O-Si-O-C	354:382	The covalent bond Fe-O-Si-O-C and the core-shell structure of FS-MC were confirmed through several characterization methods.
34323706	6	16	theme	oil	1000:1002	arg1	separation					986:995	triple-phase separation	973:995	triple-phase separation of oil, water and flocculants	973:1025	In addition, triple-phase separation of oil, water and flocculants was achieved by using magnetic FS-MC.
34323706	0	17	theme	magnetic	100:107	arg1	flocculant					109:118	composite magnetic flocculant	90:118	composite magnetic flocculant	90:118	Removal of emulsified oil from water by using recyclable chitosan based covalently bonded composite magnetic flocculant: Performance and mechanism.
34323706	0	18	from	water	31:35	arg1	Removal					0:6	Removal	0:6	Removal of emulsified oil from water by using recyclable chitosan based	0:70	Removal of emulsified oil from water by using recyclable chitosan based covalently bonded composite magnetic flocculant: Performance and mechanism.
34323706	0	18	from	water	31:35	arg1	oil					22:24	emulsified oil	11:24	emulsified oil from water	11:35	Removal of emulsified oil from water by using recyclable chitosan based covalently bonded composite magnetic flocculant: Performance and mechanism.
34323706	4	19	from	dosages	712:718	arg1	FS-MC1					683:688	FS-MC1	683:688	FS-MC1	683:688	Results showed that 94.47%, 93.95%, and 92.98% of emulsified oil could be removed by using FS-MC1, FS-MC2 and FS-MC3 at dosages of 2.0, 2.5, and 2.0 mg/L, respectively.
34323706	4	19	from	dosages	712:718	arg1	FS-MC3					702:707	FS-MC3	702:707	FS-MC3	702:707	Results showed that 94.47%, 93.95%, and 92.98% of emulsified oil could be removed by using FS-MC1, FS-MC2 and FS-MC3 at dosages of 2.0, 2.5, and 2.0 mg/L, respectively.
34323706	4	19	from	dosages	712:718	arg1	FS-MC2					691:696	FS-MC2	691:696	FS-MC2	691:696	Results showed that 94.47%, 93.95%, and 92.98% of emulsified oil could be removed by using FS-MC1, FS-MC2 and FS-MC3 at dosages of 2.0, 2.5, and 2.0 mg/L, respectively.
34323706	0	20	dep	bonded	83:88	arg1	mechanism					137:145	mechanism	137:145	mechanism	137:145	Removal of emulsified oil from water by using recyclable chitosan based covalently bonded composite magnetic flocculant: Performance and mechanism.
34323706	0	20	dep	bonded	83:88	arg1	Performance					121:131	Performance	121:131	Performance	121:131	Removal of emulsified oil from water by using recyclable chitosan based covalently bonded composite magnetic flocculant: Performance and mechanism.
34323706	8	21	theme	magnetic	1452:1459	arg1	flocculants					1467:1477	magnetic FS-MC flocculants	1452:1477	magnetic FS-MC flocculants in five cycles	1452:1492	Recycling experiments also showed that no obvious decrease of oil removal rate was observed by using magnetic FS-MC flocculants in five cycles.
34323706	2	22	theme	bond	367:370	arg1	Fe-O-Si-O-C					372:382	The covalent bond Fe-O-Si-O-C	354:382	The covalent bond Fe-O-Si-O-C	354:382	The covalent bond Fe-O-Si-O-C and the core-shell structure of FS-MC were confirmed through several characterization methods.
34323706	7	23	theme	groups	1117:1122	arg1	introduction					1076:1087	the introduction	1072:1087	the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction	1072:1221	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	7	24	theme	double	1169:1174	arg1	action					1191:1196	compression double electric-layer action	1157:1196	compression double electric-layer action	1157:1196	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	7	24	theme	double	1169:1174	arg1	FS-MC					1127:1131	FS-MC	1127:1131	FS-MC	1127:1131	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	1	25	theme	novel	164:168	arg1	FS-MC					220:224	FS-MC	220:224	FS-MC	220:224	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	1	25	theme	novel	164:168	arg1	flocculant					208:217	a novel recyclable covalently bonded magnetic flocculant	162:217	a novel recyclable covalently bonded magnetic flocculant (FS-MC)	162:225	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	1	26	theme	chitosan-based	266:279	arg1	polymers					290:297	chitosan-based modified polymers	266:297	chitosan-based modified polymers (MCS)	266:303	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	1	26	theme	chitosan-based	266:279	arg1	MCS					300:302	MCS	300:302	MCS	300:302	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	3	27	dep	flocculation	510:521	arg1	performance					523:533	performance	523:533	performance	523:533	The emulsified oily wastewater flocculation performance and mechanism by using FS-MC were evaluated and studied.
34323706	1	28	theme	recyclable	170:179	arg1	FS-MC					220:224	FS-MC	220:224	FS-MC	220:224	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	1	28	theme	recyclable	170:179	arg1	flocculant					208:217	a novel recyclable covalently bonded magnetic flocculant	162:217	a novel recyclable covalently bonded magnetic flocculant (FS-MC)	162:225	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	2	29	theme	FS-MC	416:420	arg1	Fe-O-Si-O-C					372:382	The covalent bond Fe-O-Si-O-C	354:382	The covalent bond Fe-O-Si-O-C	354:382	The covalent bond Fe-O-Si-O-C and the core-shell structure of FS-MC were confirmed through several characterization methods.
34323706	2	29	theme	FS-MC	416:420	arg1	structure					403:411	the core-shell structure	388:411	the core-shell structure of FS-MC	388:420	The covalent bond Fe-O-Si-O-C and the core-shell structure of FS-MC were confirmed through several characterization methods.
34323706	1	30	theme	modified	281:288	arg1	polymers					290:297	chitosan-based modified polymers	266:297	chitosan-based modified polymers (MCS)	266:303	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	1	30	theme	modified	281:288	arg1	MCS					300:302	MCS	300:302	MCS	300:302	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	7	31	theme	emulsified	1335:1344	arg1	oil					1346:1348	emulsified oil	1335:1348	emulsified oil	1335:1348	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	5	32	theme	chain	895:899	arg1	alkanes					901:907	long chain alkanes	890:907	long chain alkanes	890:907	Furthermore, FS-MC exhibited an excellent behavior on the removal of organic compounds with molecular weight > 10 kDa, including long chain alkanes, cycloalkanes, and aromatic hydrocarbon compounds.
34323706	0	33	theme	emulsified	11:20	arg1	oil					22:24	emulsified oil	11:24	emulsified oil from water	11:35	Removal of emulsified oil from water by using recyclable chitosan based covalently bonded composite magnetic flocculant: Performance and mechanism.
34323706	5	34	theme	long	890:893	arg1	alkanes					901:907	long chain alkanes	890:907	long chain alkanes	890:907	Furthermore, FS-MC exhibited an excellent behavior on the removal of organic compounds with molecular weight > 10 kDa, including long chain alkanes, cycloalkanes, and aromatic hydrocarbon compounds.
34323706	1	35	theme	bonded	192:197	arg1	FS-MC					220:224	FS-MC	220:224	FS-MC	220:224	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	1	35	theme	bonded	192:197	arg1	flocculant					208:217	a novel recyclable covalently bonded magnetic flocculant	162:217	a novel recyclable covalently bonded magnetic flocculant (FS-MC)	162:225	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	4	36	theme	oil	653:655	arg1	%					617:617	94.47%	612:617	94.47%	612:617	Results showed that 94.47%, 93.95%, and 92.98% of emulsified oil could be removed by using FS-MC1, FS-MC2 and FS-MC3 at dosages of 2.0, 2.5, and 2.0 mg/L, respectively.
34323706	4	36	theme	oil	653:655	arg1	%					625:625	93.95%	620:625	93.95%	620:625	Results showed that 94.47%, 93.95%, and 92.98% of emulsified oil could be removed by using FS-MC1, FS-MC2 and FS-MC3 at dosages of 2.0, 2.5, and 2.0 mg/L, respectively.
34323706	4	36	theme	oil	653:655	arg1	%					637:637	92.98%	632:637	92.98%	632:637	Results showed that 94.47%, 93.95%, and 92.98% of emulsified oil could be removed by using FS-MC1, FS-MC2 and FS-MC3 at dosages of 2.0, 2.5, and 2.0 mg/L, respectively.
34323706	4	36	theme	oil	653:655	arg1	oil					653:655	emulsified oil	642:655	emulsified oil	642:655	Results showed that 94.47%, 93.95%, and 92.98% of emulsified oil could be removed by using FS-MC1, FS-MC2 and FS-MC3 at dosages of 2.0, 2.5, and 2.0 mg/L, respectively.
34323706	7	37	theme	hydrophobic	1199:1209	arg1	FS-MC					1127:1131	FS-MC	1127:1131	FS-MC	1127:1131	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	7	37	theme	hydrophobic	1199:1209	arg1	interaction					1211:1221	hydrophobic interaction	1199:1221	hydrophobic interaction	1199:1221	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	4	38	theme	emulsified	642:651	arg1	oil					653:655	emulsified oil	642:655	emulsified oil	642:655	Results showed that 94.47%, 93.95%, and 92.98% of emulsified oil could be removed by using FS-MC1, FS-MC2 and FS-MC3 at dosages of 2.0, 2.5, and 2.0 mg/L, respectively.
34323706	1	39	theme	magnetic	199:206	arg1	FS-MC					220:224	FS-MC	220:224	FS-MC	220:224	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	1	39	theme	magnetic	199:206	arg1	flocculant					208:217	a novel recyclable covalently bonded magnetic flocculant	162:217	a novel recyclable covalently bonded magnetic flocculant (FS-MC)	162:225	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	2	40	theme	characterization	453:468	arg1	methods					470:476	several characterization methods	445:476	several characterization methods	445:476	The covalent bond Fe-O-Si-O-C and the core-shell structure of FS-MC were confirmed through several characterization methods.
34323706	7	41	theme	cationic	1092:1099	arg1	groups					1117:1122	cationic and hydrophobic groups	1092:1122	cationic and hydrophobic groups	1092:1122	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	0	42	theme	oil	22:24	arg1	Removal					0:6	Removal	0:6	Removal of emulsified oil from water by using recyclable chitosan based	0:70	Removal of emulsified oil from water by using recyclable chitosan based covalently bonded composite magnetic flocculant: Performance and mechanism.
34323706	5	43	theme	excellent	793:801	arg1	behavior					803:810	an excellent behavior	790:810	an excellent behavior on the removal of organic compounds with molecular weight > 10 kDa, including long chain alkanes, cycloalkanes, and aromatic hydrocarbon compounds	790:957	Furthermore, FS-MC exhibited an excellent behavior on the removal of organic compounds with molecular weight > 10 kDa, including long chain alkanes, cycloalkanes, and aromatic hydrocarbon compounds.
34323706	2	44	theme	several	445:451	arg1	methods					470:476	several characterization methods	445:476	several characterization methods	445:476	The covalent bond Fe-O-Si-O-C and the core-shell structure of FS-MC were confirmed through several characterization methods.
34323706	7	45	theme	charge	1134:1139	arg1	FS-MC					1127:1131	FS-MC	1127:1131	FS-MC	1127:1131	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	7	45	theme	charge	1134:1139	arg1	neutralization					1141:1154	charge neutralization	1134:1154	charge neutralization	1134:1154	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	7	46	theme	electric-layer	1176:1189	arg1	action					1191:1196	compression double electric-layer action	1157:1196	compression double electric-layer action	1157:1196	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	7	46	theme	electric-layer	1176:1189	arg1	FS-MC					1127:1131	FS-MC	1127:1131	FS-MC	1127:1131	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	8	47	theme	Recycling	1351:1359	arg1	experiments					1361:1371	Recycling experiments	1351:1371	Recycling experiments	1351:1371	Recycling experiments also showed that no obvious decrease of oil removal rate was observed by using magnetic FS-MC flocculants in five cycles.
34323706	3	48	theme	emulsified	483:492	arg1	flocculation					510:521	The emulsified oily wastewater flocculation performance and mechanism	479:547	flocculation	510:521	The emulsified oily wastewater flocculation performance and mechanism by using FS-MC were evaluated and studied.
34323706	6	49	theme	water	1005:1009	arg1	separation					986:995	triple-phase separation	973:995	triple-phase separation of oil, water and flocculants	973:1025	In addition, triple-phase separation of oil, water and flocculants was achieved by using magnetic FS-MC.
34323706	8	50	theme	FS-MC	1461:1465	arg1	flocculants					1467:1477	magnetic FS-MC flocculants	1452:1477	magnetic FS-MC flocculants in five cycles	1452:1492	Recycling experiments also showed that no obvious decrease of oil removal rate was observed by using magnetic FS-MC flocculants in five cycles.
34323706	8	51	theme	removal	1417:1423	arg1	rate					1425:1428	oil removal rate	1413:1428	oil removal rate	1413:1428	Recycling experiments also showed that no obvious decrease of oil removal rate was observed by using magnetic FS-MC flocculants in five cycles.
34323706	3	52	theme	oily	494:497	arg1	flocculation					510:521	The emulsified oily wastewater flocculation performance and mechanism	479:547	flocculation	510:521	The emulsified oily wastewater flocculation performance and mechanism by using FS-MC were evaluated and studied.
34323706	1	53	theme	Fe3O4	310:314	arg1	SiO2					316:319	Fe3O4@SiO2	310:319	Fe3O4@SiO2 through a silane coupling agent	310:351	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	7	54	theme	oil	1346:1348	arg1	removal					1324:1330	the removal	1320:1330	the removal of emulsified oil	1320:1348	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	5	55	theme	aromatic	928:935	arg1	compounds					949:957	aromatic hydrocarbon compounds	928:957	aromatic hydrocarbon compounds	928:957	Furthermore, FS-MC exhibited an excellent behavior on the removal of organic compounds with molecular weight > 10 kDa, including long chain alkanes, cycloalkanes, and aromatic hydrocarbon compounds.
34323706	6	56	theme	triple-phase	973:984	arg1	separation					986:995	triple-phase separation	973:995	triple-phase separation of oil, water and flocculants	973:1025	In addition, triple-phase separation of oil, water and flocculants was achieved by using magnetic FS-MC.
34323706	5	57	theme	molecular	853:861	arg1	weight					863:868	molecular weight > 10 kDa	853:877	molecular weight > 10 kDa	853:877	Furthermore, FS-MC exhibited an excellent behavior on the removal of organic compounds with molecular weight > 10 kDa, including long chain alkanes, cycloalkanes, and aromatic hydrocarbon compounds.
34323706	5	58	theme	hydrocarbon	937:947	arg1	compounds					949:957	aromatic hydrocarbon compounds	928:957	aromatic hydrocarbon compounds	928:957	Furthermore, FS-MC exhibited an excellent behavior on the removal of organic compounds with molecular weight > 10 kDa, including long chain alkanes, cycloalkanes, and aromatic hydrocarbon compounds.
34323706	7	59	theme	interfacial	1224:1234	arg1	adsorption					1236:1245	interfacial adsorption	1224:1245	interfacial adsorption bridging	1224:1254	Due to the introduction of cationic and hydrophobic groups in FS-MC, charge neutralization, compression double electric-layer action, hydrophobic interaction, interfacial adsorption bridging and sweep-flocculation synergistically contributed and enhanced the removal of emulsified oil.
34323706	0	60	theme	chitosan	57:64	arg1	based					66:70	recyclable chitosan based	46:70	recyclable chitosan based	46:70	Removal of emulsified oil from water by using recyclable chitosan based covalently bonded composite magnetic flocculant: Performance and mechanism.
34323706	8	61	theme	rate	1425:1428	arg1	decrease					1401:1408	no obvious decrease	1390:1408	no obvious decrease of oil removal rate	1390:1428	Recycling experiments also showed that no obvious decrease of oil removal rate was observed by using magnetic FS-MC flocculants in five cycles.
34323706	6	62	theme	magnetic	1049:1056	arg1	FS-MC					1058:1062	magnetic FS-MC	1049:1062	magnetic FS-MC	1049:1062	In addition, triple-phase separation of oil, water and flocculants was achieved by using magnetic FS-MC.
34323706	6	63	theme	flocculants	1015:1025	arg1	separation					986:995	triple-phase separation	973:995	triple-phase separation of oil, water and flocculants	973:1025	In addition, triple-phase separation of oil, water and flocculants was achieved by using magnetic FS-MC.
34323706	0	64	theme	recyclable	46:55	arg1	based					66:70	recyclable chitosan based	46:70	recyclable chitosan based	46:70	Removal of emulsified oil from water by using recyclable chitosan based covalently bonded composite magnetic flocculant: Performance and mechanism.
34323706	1	65	theme	@	315:315	arg1	SiO2					316:319	Fe3O4@SiO2	310:319	Fe3O4@SiO2 through a silane coupling agent	310:351	In this work, a novel recyclable covalently bonded magnetic flocculant (FS-MC) was successfully prepared by combining chitosan-based modified polymers (MCS) with Fe3O4@SiO2 through a silane coupling agent.
34323706	4	66	theme	2.0 mg/L	737:744	arg1	dosages					712:718	dosages	712:718	dosages of 2.0, 2.5, and 2.0 mg/L, respectively	712:758	Results showed that 94.47%, 93.95%, and 92.98% of emulsified oil could be removed by using FS-MC1, FS-MC2 and FS-MC3 at dosages of 2.0, 2.5, and 2.0 mg/L, respectively.
34323706	5	67	from	behavior	803:810	arg1	removal					819:825	the removal	815:825	the removal of organic compounds with molecular weight > 10 kDa, including long chain alkanes, cycloalkanes, and aromatic hydrocarbon compounds	815:957	Furthermore, FS-MC exhibited an excellent behavior on the removal of organic compounds with molecular weight > 10 kDa, including long chain alkanes, cycloalkanes, and aromatic hydrocarbon compounds.
34323706	5	68	theme	organic	830:836	arg1	compounds					838:846	organic compounds	830:846	organic compounds with molecular weight > 10 kDa	830:877	Furthermore, FS-MC exhibited an excellent behavior on the removal of organic compounds with molecular weight > 10 kDa, including long chain alkanes, cycloalkanes, and aromatic hydrocarbon compounds.
34323706	8	69	theme	obvious	1393:1399	arg1	decrease					1401:1408	no obvious decrease	1390:1408	no obvious decrease of oil removal rate	1390:1428	Recycling experiments also showed that no obvious decrease of oil removal rate was observed by using magnetic FS-MC flocculants in five cycles.
33743019	1	0	theme	carbon	199:204	arg1	material					252:259	reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material	162:259	reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material	162:259	In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY).
33743019	1	1	theme	urease	353:358	arg1	enzyme					360:365	urease enzyme	353:365	urease enzyme	353:365	In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY).
33743019	5	2	theme	environmental	1090:1102	arg1	monitoring					1104:1113	environmental monitoring	1090:1113	environmental monitoring	1090:1113	The developed composite will probably provide an universal electrochemical sensing platform that is very promising for environmental monitoring.
33743019	1	3	theme	nanotubes/octahedral-Fe3O4/chitosan	206:240	arg1	material					252:259	reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material	162:259	reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material	162:259	In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY).
33743019	1	4	theme	enzyme	360:365	arg1	inhibition					339:348	inhibition	339:348	inhibition of urease enzyme	339:365	In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY).
33743019	3	5	from	of ~ 0.08 ppb	700:712	arg1	range					739:743	a large concentration range	717:743	a large concentration range of 0.1-1000 ppb	717:759	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	0	6	theme	Glyphosate	126:135	arg1	Detection					137:145	Glyphosate Detection	126:145	Glyphosate Detection	126:145	Electrochemical Sensor Based on Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection.
33743019	4	7	theme	106.9	925:929	arg1	%					920:920	%	920:920	%	920:920	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	2	8	from	behaviors	444:452	arg1	electrodes					470:479	these electrodes	464:479	these electrodes	464:479	The electrochemical behaviors of GLY on these electrodes were evaluated by square wave voltammetry (SWV).
33743019	2	9	theme	GLY	457:459	arg1	behaviors					444:452	The electrochemical behaviors	424:452	The electrochemical behaviors of GLY on these electrodes	424:479	The electrochemical behaviors of GLY on these electrodes were evaluated by square wave voltammetry (SWV).
33743019	4	10	with	samples	847:853	arg1	recoveries					860:869	recoveries	860:869	recoveries	860:869	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	4	10	with	samples	847:853	arg1	RSDs					905:908	RSDs	905:908	RSDs	905:908	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	4	10	with	samples	847:853	arg1	deviations					893:902	relative standard deviations	875:902	relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively	875:968	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	4	11	theme	water	841:845	arg1	samples					847:853	river water samples	835:853	river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively	835:968	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	1	12	theme	composite	242:250	arg1	material					252:259	reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material	162:259	reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material	162:259	In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY).
33743019	4	13	dep	%	920:920	arg1	to					922:923	to	922:923	to	922:923	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	4	14	theme	river	835:839	arg1	samples					847:853	river water samples	835:853	river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively	835:968	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	3	15	theme	bare	599:602	arg1	SPAuE					604:608	bare SPAuE	599:608	bare SPAuE	599:608	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	4	16	theme	98.7	916:919	arg1	%					920:920	%	920:920	%	920:920	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	4	17	from	determination	811:823	arg1	samples					847:853	river water samples	835:853	river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively	835:968	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	0	18	theme	Electrochemical	0:14	arg1	Sensor					16:21	Electrochemical Sensor	0:21	Electrochemical Sensor	0:21	Electrochemical Sensor Based on Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection.
33743019	3	19	theme	GLY	662:664	arg1	detection					649:657	detection	649:657	detection of GLY	649:664	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	1	20	theme	screen-printed	270:283	arg1	electrodes					290:299	screen-printed gold electrodes	270:299	screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE)	270:331	In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY).
33743019	1	20	theme	screen-printed	270:283	arg1	rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE					302:330	rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE	302:330	rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE	302:330	In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY).
33743019	5	21	theme	electrochemical	1030:1044	arg1	promising					1076:1084	promising	1076:1084	promising	1076:1084	The developed composite will probably provide an universal electrochemical sensing platform that is very promising for environmental monitoring.
33743019	5	21	theme	electrochemical	1030:1044	arg1	platform					1054:1061	an universal electrochemical sensing platform	1017:1061	an universal electrochemical sensing platform that is very promising for environmental monitoring	1017:1113	The developed composite will probably provide an universal electrochemical sensing platform that is very promising for environmental monitoring.
33743019	4	22	theme	standard	884:891	arg1	RSDs					905:908	RSDs	905:908	RSDs	905:908	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	4	22	theme	standard	884:891	arg1	deviations					893:902	relative standard deviations	875:902	relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively	875:968	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	1	23	theme	gold	285:288	arg1	electrodes					290:299	screen-printed gold electrodes	270:299	screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE)	270:331	In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY).
33743019	1	23	theme	gold	285:288	arg1	rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE					302:330	rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE	302:330	rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE	302:330	In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY).
33743019	5	24	theme	developed	975:983	arg1	composite					985:993	The developed composite	971:993	The developed composite	971:993	The developed composite will probably provide an universal electrochemical sensing platform that is very promising for environmental monitoring.
33743019	0	25	theme	Graphene	40:47	arg1	Composite					112:120	Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite	32:120	Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection	32:145	Electrochemical Sensor Based on Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection.
33743019	3	26	theme	higher	579:584	arg1	times					573:577	1.7 times	569:577	1.7 times higher than that of bare SPAuE	569:608	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	3	27	theme	large	719:723	arg1	range					739:743	a large concentration range	717:743	a large concentration range of 0.1-1000 ppb	717:759	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	3	28	theme	low	674:676	arg1	LOD					695:697	LOD	695:697	LOD	695:697	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	3	28	theme	low	674:676	arg1	limit					688:692	a low detection limit	672:692	a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb	672:759	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	2	29	theme	wave	506:509	arg1	SWV					524:526	SWV	524:526	SWV	524:526	The electrochemical behaviors of GLY on these electrodes were evaluated by square wave voltammetry (SWV).
33743019	2	29	theme	wave	506:509	arg1	voltammetry					511:521	square wave voltammetry	499:521	square wave voltammetry (SWV)	499:527	The electrochemical behaviors of GLY on these electrodes were evaluated by square wave voltammetry (SWV).
33743019	0	30	theme	Reduced	32:38	arg1	Composite					112:120	Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite	32:120	Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection	32:145	Electrochemical Sensor Based on Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection.
33743019	1	31	theme	glyphosate	406:415	arg1	determination					389:401	the determination	385:401	the determination of glyphosate (GLY)	385:421	In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY).
33743019	4	32	theme	GLY	828:830	arg1	determination					811:823	the determination	807:823	the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively	807:968	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	3	33	theme	detection	678:686	arg1	LOD					695:697	LOD	695:697	LOD	695:697	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	3	33	theme	detection	678:686	arg1	limit					688:692	a low detection limit	672:692	a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb	672:759	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	2	34	theme	square	499:504	arg1	SWV					524:526	SWV	524:526	SWV	524:526	The electrochemical behaviors of GLY on these electrodes were evaluated by square wave voltammetry (SWV).
33743019	2	34	theme	square	499:504	arg1	voltammetry					511:521	square wave voltammetry	499:521	square wave voltammetry (SWV)	499:527	The electrochemical behaviors of GLY on these electrodes were evaluated by square wave voltammetry (SWV).
33743019	0	35	theme	Carbon	69:74	arg1	Composite					112:120	Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite	32:120	Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection	32:145	Electrochemical Sensor Based on Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection.
33743019	0	36	theme	Oxide/Double-Walled	49:67	arg1	Composite					112:120	Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite	32:120	Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection	32:145	Electrochemical Sensor Based on Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection.
33743019	2	37	theme	electrochemical	428:442	arg1	behaviors					444:452	The electrochemical behaviors	424:452	The electrochemical behaviors of GLY on these electrodes	424:479	The electrochemical behaviors of GLY on these electrodes were evaluated by square wave voltammetry (SWV).
33743019	5	38	theme	sensing	1046:1052	arg1	promising					1076:1084	promising	1076:1084	promising	1076:1084	The developed composite will probably provide an universal electrochemical sensing platform that is very promising for environmental monitoring.
33743019	5	38	theme	sensing	1046:1052	arg1	platform					1054:1061	an universal electrochemical sensing platform	1017:1061	an universal electrochemical sensing platform that is very promising for environmental monitoring	1017:1113	The developed composite will probably provide an universal electrochemical sensing platform that is very promising for environmental monitoring.
33743019	4	39	theme	%	945:945	arg1	%					954:954	0.79% to 0.87%	941:954	0.79% to 0.87%	941:954	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	3	40	theme	0.1-1000 ppb	748:759	arg1	range					739:743	a large concentration range	717:743	a large concentration range of 0.1-1000 ppb	717:759	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	4	41	theme	relative	875:882	arg1	RSDs					905:908	RSDs	905:908	RSDs	905:908	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	4	41	theme	relative	875:882	arg1	deviations					893:902	relative standard deviations	875:902	relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively	875:968	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	3	42	theme	concentration	725:737	arg1	range					739:743	a large concentration range	717:743	a large concentration range of 0.1-1000 ppb	717:759	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	5	43	theme	universal	1020:1028	arg1	promising					1076:1084	promising	1076:1084	promising	1076:1084	The developed composite will probably provide an universal electrochemical sensing platform that is very promising for environmental monitoring.
33743019	5	43	theme	universal	1020:1028	arg1	platform					1054:1061	an universal electrochemical sensing platform	1017:1061	an universal electrochemical sensing platform that is very promising for environmental monitoring	1017:1113	The developed composite will probably provide an universal electrochemical sensing platform that is very promising for environmental monitoring.
33743019	4	44	from	%	954:954	arg1	recoveries					860:869	recoveries	860:869	recoveries	860:869	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	4	44	from	%	954:954	arg1	RSDs					905:908	RSDs	905:908	RSDs	905:908	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	4	44	from	%	954:954	arg1	deviations					893:902	relative standard deviations	875:902	relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively	875:968	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	1	45	theme	reduced	162:168	arg1	material					252:259	reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material	162:259	reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material	162:259	In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY).
33743019	0	46	theme	Fe3O4/Chitosan	97:110	arg1	Composite					112:120	Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite	32:120	Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection	32:145	Electrochemical Sensor Based on Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection.
33743019	3	47	theme	electroactive	539:551	arg1	area					561:564	the electroactive surface area	535:564	the electroactive surface area is 1.7 times higher than that of bare SPAuE	535:608	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	3	48	theme	limit	688:692	arg1	of ~ 0.08 ppb					700:712	a low detection limit (LOD) of ~ 0.08 ppb	672:712	a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb	672:759	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	3	49	theme	surface	553:559	arg1	area					561:564	the electroactive surface area	535:564	the electroactive surface area is 1.7 times higher than that of bare SPAuE	535:608	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	1	50	theme	graphene	170:177	arg1	material					252:259	reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material	162:259	reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material	162:259	In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY).
33743019	0	51	theme	Nanotubes/Octahedral	76:95	arg1	Composite					112:120	Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite	32:120	Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection	32:145	Electrochemical Sensor Based on Reduced Graphene Oxide/Double-Walled Carbon Nanotubes/Octahedral Fe3O4/Chitosan Composite for Glyphosate Detection.
33743019	4	52	from	%	930:930	arg1	recoveries					860:869	recoveries	860:869	recoveries	860:869	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	4	52	from	%	930:930	arg1	RSDs					905:908	RSDs	905:908	RSDs	905:908	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	4	52	from	%	930:930	arg1	deviations					893:902	relative standard deviations	875:902	relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively	875:968	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
33743019	3	53	dep	area	561:564	arg1	times					573:577	1.7 times	569:577	1.7 times higher than that of bare SPAuE	569:608	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.
33743019	1	54	theme	oxide/double-walled	179:197	arg1	material					252:259	reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material	162:259	reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material	162:259	In this work, reduced graphene oxide/double-walled carbon nanotubes/octahedral-Fe3O4/chitosan composite material modified screen-printed gold electrodes (rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE) under inhibition of urease enzyme was developed for the determination of glyphosate (GLY).
33743019	4	55	dep	%	954:954	arg1	to					947:948	to	947:948	to	947:948	Moreover, it is also successfully applied to the determination of GLY in river water samples with recoveries and relative standard deviations (RSDs) from 98.7% to 106.9% and from 0.79% to 0.87%, respectively.
32867865	0	0	theme	temperature	10:20	arg1	Effect					0:5	Effect	0:5	Effect of temperature and/or sweetness of beverages on body composition in rats.	0:79	Effect of temperature and/or sweetness of beverages on body composition in rats.
32867865	10	1	theme	fat	1404:1406	arg1	gain					1408:1411	body fat gain	1399:1411	body fat gain due to improved energy efficiency	1399:1445	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	9	2	theme	temperature	1202:1212	arg1	type					1180:1183	the type	1176:1183	the type of sweeteners or temperature	1176:1212	In Expt 2, body weight (P = 0·013) and fat (P ≤ 0·001) gains were higher in the non-energetic sweetened groups, while lean body mass was not affected by the type of sweeteners or temperature.
32867865	7	3	dep	water	764:768	arg1	CAk					832:834	0·05 % acesulfame K CAk	812:834	0·05 % acesulfame K CAk (n 6)	812:840	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	3	dep	water	764:768	arg1	NAk					846:848	NAk	846:848	NAk (n 8)	846:854	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	3	dep	water	764:768	arg1	NSu					798:800	NSu	798:800	NSu	798:800	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	3	dep	water	764:768	arg1	n					851:851	n 8	851:853	n 8	851:853	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	3	dep	water	764:768	arg1	CSu					784:786	10 % sucrose CSu	771:786	10 % sucrose CSu (n 7)	771:792	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	3	dep	water	764:768	arg1	n					837:837	n 6	837:839	n 6	837:839	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	3	dep	water	764:768	arg1	n					789:789	n 7	789:791	n 7	789:791	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	3	dep	water	764:768	arg1	n					803:803	n 8	803:805	n 8	803:805	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	10	4	theme	mass	1270:1273	arg1	gain					1275:1278	lean body mass gain	1260:1278	lean body mass gain	1260:1278	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	9	5	theme	body	1034:1037	arg1	P					1047:1047	P = 0·013	1047:1055	P = 0·013	1047:1055	In Expt 2, body weight (P = 0·013) and fat (P ≤ 0·001) gains were higher in the non-energetic sweetened groups, while lean body mass was not affected by the type of sweeteners or temperature.
32867865	9	5	theme	body	1034:1037	arg1	weight					1039:1044	body weight	1034:1044	body weight (P = 0·013)	1034:1056	In Expt 2, body weight (P = 0·013) and fat (P ≤ 0·001) gains were higher in the non-energetic sweetened groups, while lean body mass was not affected by the type of sweeteners or temperature.
32867865	0	6	from	Effect	0:5	arg1	composition					60:70	body composition	55:70	body composition in rats	55:78	Effect of temperature and/or sweetness of beverages on body composition in rats.
32867865	2	7	theme	cold	290:293	arg1	beverages					295:303	cold beverages	290:303	cold beverages	290:303	However, the effect of internal temperature variations through the ingestion of cold beverages is far from clear.
32867865	7	8	theme	C	751:751	arg1	water					764:768	cold (C) sweetened water	745:768	cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8))	745:855	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	10	9	theme	lean	1260:1263	arg1	gain					1275:1278	lean body mass gain	1260:1278	lean body mass gain	1260:1278	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	7	10	theme	%	817:817	arg1	CAk					832:834	0·05 % acesulfame K CAk	812:834	0·05 % acesulfame K CAk (n 6)	812:840	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	10	theme	%	817:817	arg1	n					837:837	n 6	837:839	n 6	837:839	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	11	11	theme	Internal	1448:1455	arg1	exposure					1462:1469	Internal cold exposure	1448:1469	Internal cold exposure	1448:1469	Internal cold exposure failed to increase energy intake in contrast to that of external cold exposure.
32867865	9	12	theme	sweetened	1117:1125	arg1	groups					1127:1132	the non-energetic sweetened groups	1099:1132	the non-energetic sweetened groups	1099:1132	In Expt 2, body weight (P = 0·013) and fat (P ≤ 0·001) gains were higher in the non-energetic sweetened groups, while lean body mass was not affected by the type of sweeteners or temperature.
32867865	6	13	theme	room	635:638	arg1	temperature					640:650	room temperature	635:650	room temperature (NW about 22°C)	635:666	In Expt 1, two groups of rats (n 9) consumed water at room temperature (NW about 22°C) or cold (CW about 4°C).
32867865	6	13	theme	room	635:638	arg1	NW					653:654	NW about 22°C	653:665	NW about 22°C	653:665	In Expt 1, two groups of rats (n 9) consumed water at room temperature (NW about 22°C) or cold (CW about 4°C).
32867865	4	14	theme	free	471:474	arg1	access					476:481	free access	471:481	free access to food and beverage for 8 weeks	471:514	Sprague-Dawley rats (5-6-week-old males) had free access to food and beverage for 8 weeks.
32867865	7	15	theme	sweetened	754:762	arg1	water					764:768	cold (C) sweetened water	745:768	cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8))	745:855	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	16	theme	cold	745:748	arg1	water					764:768	cold (C) sweetened water	745:768	cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8))	745:855	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	8	17	theme	higher	932:937	arg1	0·001					959:963	P < 0·001	955:963	P < 0·001	955:963	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	17	theme	higher	932:937	arg1	mass					949:952	higher lean body mass	932:952	higher lean body mass (P < 0·001)	932:964	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	10	18	theme	increased	1314:1322	arg1	expenditure					1331:1341	increased energy expenditure	1314:1341	increased energy expenditure	1314:1341	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	5	19	theme	body	548:551	arg1	composition					553:563	body composition	548:563	body composition	548:563	Energy intake, body weight and body composition were monitored.
32867865	10	20	theme	fat	1294:1296	arg1	gain					1298:1301	decreased fat gain	1284:1301	decreased fat gain	1284:1301	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	9	21	theme	=	1049:1049	arg1	P					1047:1047	P = 0·013	1047:1055	P = 0·013	1047:1055	In Expt 2, body weight (P = 0·013) and fat (P ≤ 0·001) gains were higher in the non-energetic sweetened groups, while lean body mass was not affected by the type of sweeteners or temperature.
32867865	9	21	theme	=	1049:1049	arg1	weight					1039:1044	body weight	1034:1044	body weight (P = 0·013)	1034:1056	In Expt 2, body weight (P = 0·013) and fat (P ≤ 0·001) gains were higher in the non-energetic sweetened groups, while lean body mass was not affected by the type of sweeteners or temperature.
32867865	8	22	contain	had	928:930	arg2	P					991:991	P = 0·004	991:999	P = 0·004	991:999	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	22	contain	had	928:930	arg2	gain					985:988	lower body fat gain	970:988	lower body fat gain (P = 0·004)	970:1000	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	22	contain	had	928:930	arg2	0·001					959:963	P < 0·001	955:963	P < 0·001	955:963	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	22	contain	had	928:930	arg2	mass					949:952	higher lean body mass	932:952	higher lean body mass (P < 0·001)	932:964	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	22	contain	had	928:930	arg1	CW					925:926	CW	925:926	CW	925:926	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	3	23	from	effect	374:379	arg1	composition					413:423	body composition	408:423	body composition	408:423	Two experiments were conducted to investigate the effect of beverage temperature on body composition.
32867865	8	24	theme	body	944:947	arg1	0·001					959:963	P < 0·001	955:963	P < 0·001	955:963	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	24	theme	body	944:947	arg1	mass					949:952	higher lean body mass	932:952	higher lean body mass (P < 0·001)	932:964	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	3	25	theme	beverage	384:391	arg1	temperature					393:403	beverage temperature	384:403	beverage temperature	384:403	Two experiments were conducted to investigate the effect of beverage temperature on body composition.
32867865	10	26	theme	acesulfame	1375:1384	arg1	sweetener					1364:1372	non-energetic sweetener	1350:1372	non-energetic sweetener (acesulfame K)	1350:1387	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	10	26	theme	acesulfame	1375:1384	arg1	K					1386:1386	acesulfame K	1375:1386	acesulfame K	1375:1386	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	7	27	theme	sucrose	776:782	arg1	n					789:789	n 7	789:791	n 7	789:791	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	27	theme	sucrose	776:782	arg1	CSu					784:786	10 % sucrose CSu	771:786	10 % sucrose CSu (n 7)	771:792	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	27	theme	sucrose	776:782	arg1	n					803:803	n 8	803:805	n 8	803:805	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	2	28	dep	clear	317:321	arg1	effect					223:228	the effect	219:228	the effect of internal temperature variations through the ingestion of cold beverages	219:303	However, the effect of internal temperature variations through the ingestion of cold beverages is far from clear.
32867865	2	28	dep	clear	317:321	arg1	clear					317:321	clear	317:321	clear	317:321	However, the effect of internal temperature variations through the ingestion of cold beverages is far from clear.
32867865	2	28	dep	clear	317:321	arg1	from					312:315	from	312:315	from	312:315	However, the effect of internal temperature variations through the ingestion of cold beverages is far from clear.
32867865	1	29	theme	external	177:184	arg1	variations					198:207	external temperature variations	177:207	external temperature variations	177:207	Sweetened beverages are mainly consumed cold and various processes are activated in response to external temperature variations.
32867865	7	30	theme	plain	879:883	arg1	water					885:889	plain water	879:889	plain water	879:889	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	9	31	theme	body	1146:1149	arg1	mass					1151:1154	lean body mass	1141:1154	lean body mass	1141:1154	In Expt 2, body weight (P = 0·013) and fat (P ≤ 0·001) gains were higher in the non-energetic sweetened groups, while lean body mass was not affected by the type of sweeteners or temperature.
32867865	1	32	theme	temperature	186:196	arg1	variations					198:207	external temperature variations	177:207	external temperature variations	177:207	Sweetened beverages are mainly consumed cold and various processes are activated in response to external temperature variations.
32867865	1	33	theme	Sweetened	81:89	arg1	beverages					91:99	Sweetened beverages	81:99	Sweetened beverages	81:99	Sweetened beverages are mainly consumed cold and various processes are activated in response to external temperature variations.
32867865	10	34	theme	decreased	1284:1292	arg1	gain					1298:1301	decreased fat gain	1284:1301	decreased fat gain	1284:1301	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	10	35	theme	due	1413:1415	arg1	gain					1408:1411	body fat gain	1399:1411	body fat gain due to improved energy efficiency	1399:1445	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	2	36	theme	beverages	295:303	arg1	ingestion					277:285	the ingestion	273:285	the ingestion of cold beverages	273:303	However, the effect of internal temperature variations through the ingestion of cold beverages is far from clear.
32867865	9	37	dep	weight	1039:1044	arg1	gains					1078:1082	gains	1078:1082	gains	1078:1082	In Expt 2, body weight (P = 0·013) and fat (P ≤ 0·001) gains were higher in the non-energetic sweetened groups, while lean body mass was not affected by the type of sweeteners or temperature.
32867865	4	38	contain	had	467:469	arg1	rats					441:444	Sprague-Dawley rats	426:444	Sprague-Dawley rats (5-6-week-old males)	426:465	Sprague-Dawley rats (5-6-week-old males) had free access to food and beverage for 8 weeks.
32867865	4	38	contain	had	467:469	arg1	males					460:464	5-6-week-old males	447:464	5-6-week-old males	447:464	Sprague-Dawley rats (5-6-week-old males) had free access to food and beverage for 8 weeks.
32867865	4	38	contain	had	467:469	arg2	access					476:481	free access	471:481	free access to food and beverage for 8 weeks	471:514	Sprague-Dawley rats (5-6-week-old males) had free access to food and beverage for 8 weeks.
32867865	3	39	theme	body	408:411	arg1	composition					413:423	body composition	408:423	body composition	408:423	Two experiments were conducted to investigate the effect of beverage temperature on body composition.
32867865	10	40	theme	energy	1324:1329	arg1	expenditure					1331:1341	increased energy expenditure	1314:1341	increased energy expenditure	1314:1341	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	4	41	theme	5-6-week-old	447:458	arg1	rats					441:444	Sprague-Dawley rats	426:444	Sprague-Dawley rats (5-6-week-old males)	426:465	Sprague-Dawley rats (5-6-week-old males) had free access to food and beverage for 8 weeks.
32867865	4	41	theme	5-6-week-old	447:458	arg1	males					460:464	5-6-week-old males	447:464	5-6-week-old males	447:464	Sprague-Dawley rats (5-6-week-old males) had free access to food and beverage for 8 weeks.
32867865	8	42	theme	fat	981:983	arg1	P					991:991	P = 0·004	991:999	P = 0·004	991:999	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	42	theme	fat	981:983	arg1	gain					985:988	lower body fat gain	970:988	lower body fat gain (P = 0·004)	970:1000	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	43	theme	lean	939:942	arg1	0·001					959:963	P < 0·001	955:963	P < 0·001	955:963	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	43	theme	lean	939:942	arg1	mass					949:952	higher lean body mass	932:952	higher lean body mass (P < 0·001)	932:964	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	44	theme	<	957:957	arg1	0·001					959:963	P < 0·001	955:963	P < 0·001	955:963	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	44	theme	<	957:957	arg1	mass					949:952	higher lean body mass	932:952	higher lean body mass (P < 0·001)	932:964	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	0	45	theme	sweetness	29:37	arg1	Effect					0:5	Effect	0:5	Effect of temperature and/or sweetness of beverages on body composition in rats.	0:79	Effect of temperature and/or sweetness of beverages on body composition in rats.
32867865	10	46	theme	cold	1230:1233	arg1	ingestion					1241:1249	cold water ingestion	1230:1249	cold water ingestion	1230:1249	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	0	47	from	composition	60:70	arg1	rats					75:78	rats	75:78	rats	75:78	Effect of temperature and/or sweetness of beverages on body composition in rats.
32867865	7	48	theme	0·05	812:815	arg1	%					817:817	%	817:817	%	817:817	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	8	49	theme	P	955:955	arg1	0·001					959:963	P < 0·001	955:963	P < 0·001	955:963	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	49	theme	P	955:955	arg1	mass					949:952	higher lean body mass	932:952	higher lean body mass (P < 0·001)	932:964	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	3	50	theme	temperature	393:403	arg1	effect					374:379	the effect	370:379	the effect of beverage temperature on body composition	370:423	Two experiments were conducted to investigate the effect of beverage temperature on body composition.
32867865	8	51	theme	=	993:993	arg1	P					991:991	P = 0·004	991:999	P = 0·004	991:999	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	51	theme	=	993:993	arg1	gain					985:988	lower body fat gain	970:988	lower body fat gain (P = 0·004)	970:1000	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	10	52	theme	body	1399:1402	arg1	gain					1408:1411	body fat gain	1399:1411	body fat gain due to improved energy efficiency	1399:1445	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	10	53	theme	non-energetic	1350:1362	arg1	sweetener					1364:1372	non-energetic sweetener	1350:1372	non-energetic sweetener (acesulfame K)	1350:1387	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	10	53	theme	non-energetic	1350:1362	arg1	K					1386:1386	acesulfame K	1375:1386	acesulfame K	1375:1386	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	5	54	theme	body	532:535	arg1	weight					537:542	body weight	532:542	body weight	532:542	Energy intake, body weight and body composition were monitored.
32867865	10	55	theme	body	1265:1268	arg1	gain					1275:1278	lean body mass gain	1260:1278	lean body mass gain	1260:1278	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	0	56	theme	beverages	42:50	arg1	temperature					10:20	temperature	10:20	temperature	10:20	Effect of temperature and/or sweetness of beverages on body composition in rats.
32867865	10	57	theme	improved	1420:1427	arg1	efficiency					1436:1445	improved energy efficiency	1420:1445	improved energy efficiency	1420:1445	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	4	58	theme	Sprague-Dawley	426:439	arg1	rats					441:444	Sprague-Dawley rats	426:444	Sprague-Dawley rats (5-6-week-old males)	426:465	Sprague-Dawley rats (5-6-week-old males) had free access to food and beverage for 8 weeks.
32867865	4	58	theme	Sprague-Dawley	426:439	arg1	males					460:464	5-6-week-old males	447:464	5-6-week-old males	447:464	Sprague-Dawley rats (5-6-week-old males) had free access to food and beverage for 8 weeks.
32867865	9	59	theme	lean	1141:1144	arg1	mass					1151:1154	lean body mass	1141:1154	lean body mass	1141:1154	In Expt 2, body weight (P = 0·013) and fat (P ≤ 0·001) gains were higher in the non-energetic sweetened groups, while lean body mass was not affected by the type of sweeteners or temperature.
32867865	7	60	theme	10	771:772	arg1	%					774:774	%	774:774	%	774:774	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	9	61	theme	sweeteners	1188:1197	arg1	type					1180:1183	the type	1176:1183	the type of sweeteners or temperature	1176:1212	In Expt 2, body weight (P = 0·013) and fat (P ≤ 0·001) gains were higher in the non-energetic sweetened groups, while lean body mass was not affected by the type of sweeteners or temperature.
32867865	7	62	theme	acesulfame	819:828	arg1	CAk					832:834	0·05 % acesulfame K CAk	812:834	0·05 % acesulfame K CAk (n 6)	812:840	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	62	theme	acesulfame	819:828	arg1	n					837:837	n 6	837:839	n 6	837:839	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	10	63	theme	energy	1429:1434	arg1	efficiency					1436:1445	improved energy efficiency	1420:1445	improved energy efficiency	1420:1445	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	11	64	theme	external	1527:1534	arg1	exposure					1541:1548	external cold exposure	1527:1548	external cold exposure	1527:1548	Internal cold exposure failed to increase energy intake in contrast to that of external cold exposure.
32867865	8	65	theme	lower	970:974	arg1	P					991:991	P = 0·004	991:999	P = 0·004	991:999	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	65	theme	lower	970:974	arg1	gain					985:988	lower body fat gain	970:988	lower body fat gain (P = 0·004)	970:1000	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	7	66	theme	%	774:774	arg1	n					789:789	n 7	789:791	n 7	789:791	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	66	theme	%	774:774	arg1	CSu					784:786	10 % sucrose CSu	771:786	10 % sucrose CSu (n 7)	771:792	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	66	theme	%	774:774	arg1	n					803:803	n 8	803:805	n 8	803:805	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	67	theme	K	830:830	arg1	CAk					832:834	0·05 % acesulfame K CAk	812:834	0·05 % acesulfame K CAk (n 6)	812:840	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	7	67	theme	K	830:830	arg1	n					837:837	n 6	837:839	n 6	837:839	In Expt 2, rats were offered room-temperature (N) or cold (C) sweetened water (10 % sucrose CSu (n 7) and NSu (n 8); or 0·05 % acesulfame K CAk (n 6) and NAk (n 8)) for 12 h, followed by plain water.
32867865	9	68	theme	non-energetic	1103:1115	arg1	groups					1127:1132	the non-energetic sweetened groups	1099:1132	the non-energetic sweetened groups	1099:1132	In Expt 2, body weight (P = 0·013) and fat (P ≤ 0·001) gains were higher in the non-energetic sweetened groups, while lean body mass was not affected by the type of sweeteners or temperature.
32867865	2	69	theme	variations	254:263	arg1	effect					223:228	the effect	219:228	the effect of internal temperature variations through the ingestion of cold beverages	219:303	However, the effect of internal temperature variations through the ingestion of cold beverages is far from clear.
32867865	2	69	theme	variations	254:263	arg1	clear					317:321	clear	317:321	clear	317:321	However, the effect of internal temperature variations through the ingestion of cold beverages is far from clear.
32867865	2	69	theme	variations	254:263	arg1	from					312:315	from	312:315	from	312:315	However, the effect of internal temperature variations through the ingestion of cold beverages is far from clear.
32867865	11	70	theme	cold	1536:1539	arg1	exposure					1541:1548	external cold exposure	1527:1548	external cold exposure	1527:1548	Internal cold exposure failed to increase energy intake in contrast to that of external cold exposure.
32867865	9	71	theme	P	1067:1067	arg1	fat					1062:1064	fat	1062:1064	fat (P ≤ 0·001)	1062:1076	In Expt 2, body weight (P = 0·013) and fat (P ≤ 0·001) gains were higher in the non-energetic sweetened groups, while lean body mass was not affected by the type of sweeteners or temperature.
32867865	9	71	theme	P	1067:1067	arg1	≤					1069:1069	P ≤ 0·001	1067:1075	P ≤ 0·001	1067:1075	In Expt 2, body weight (P = 0·013) and fat (P ≤ 0·001) gains were higher in the non-energetic sweetened groups, while lean body mass was not affected by the type of sweeteners or temperature.
32867865	2	72	theme	temperature	242:252	arg1	variations					254:263	internal temperature variations	233:263	internal temperature variations	233:263	However, the effect of internal temperature variations through the ingestion of cold beverages is far from clear.
32867865	10	73	theme	water	1235:1239	arg1	ingestion					1241:1249	cold water ingestion	1230:1249	cold water ingestion	1230:1249	In conclusion, cold water ingestion improved lean body mass gain and decreased fat gain because of increased energy expenditure, while non-energetic sweetener (acesulfame K) increased body fat gain due to improved energy efficiency.
32867865	1	74	theme	various	130:136	arg1	processes					138:146	various processes	130:146	various processes	130:146	Sweetened beverages are mainly consumed cold and various processes are activated in response to external temperature variations.
32867865	6	75	theme	rats	606:609	arg1	groups					596:601	two groups	592:601	two groups of rats (n 9)	592:615	In Expt 1, two groups of rats (n 9) consumed water at room temperature (NW about 22°C) or cold (CW about 4°C).
32867865	6	75	theme	rats	606:609	arg1	n					612:612	n 9	612:614	n 9	612:614	In Expt 1, two groups of rats (n 9) consumed water at room temperature (NW about 22°C) or cold (CW about 4°C).
32867865	6	75	theme	rats	606:609	arg1	rats					606:609	rats	606:609	rats (n 9)	606:615	In Expt 1, two groups of rats (n 9) consumed water at room temperature (NW about 22°C) or cold (CW about 4°C).
32867865	0	76	theme	body	55:58	arg1	composition					60:70	body composition	55:70	body composition in rats	55:78	Effect of temperature and/or sweetness of beverages on body composition in rats.
32867865	11	77	theme	energy	1490:1495	arg1	intake					1497:1502	energy intake	1490:1502	energy intake	1490:1502	Internal cold exposure failed to increase energy intake in contrast to that of external cold exposure.
32867865	2	78	theme	internal	233:240	arg1	variations					254:263	internal temperature variations	233:263	internal temperature variations	233:263	However, the effect of internal temperature variations through the ingestion of cold beverages is far from clear.
32867865	5	79	theme	Energy	517:522	arg1	intake					524:529	Energy intake	517:529	Energy intake	517:529	Energy intake, body weight and body composition were monitored.
32867865	8	80	theme	body	976:979	arg1	P					991:991	P = 0·004	991:999	P = 0·004	991:999	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	8	80	theme	body	976:979	arg1	gain					985:988	lower body fat gain	970:988	lower body fat gain (P = 0·004)	970:1000	Our results show that in Expt 1, CW had higher lean body mass (P < 0·001) and lower body fat gain (P = 0·004) as compared with NW.
32867865	11	81	theme	cold	1457:1460	arg1	exposure					1462:1469	Internal cold exposure	1448:1469	Internal cold exposure	1448:1469	Internal cold exposure failed to increase energy intake in contrast to that of external cold exposure.
33039532	8	0	with	materials	1130:1138	arg1	reactivity					1174:1183	reactivity	1174:1183	reactivity	1174:1183	The catalyst was readily prepared from inexpensive materials with considerable reusability and reactivity.
33039532	8	0	with	materials	1130:1138	arg1	reusability					1158:1168	considerable reusability	1145:1168	considerable reusability	1145:1168	The catalyst was readily prepared from inexpensive materials with considerable reusability and reactivity.
33039532	4	1	theme	reaction	656:663	arg1	conditions					665:674	the best reaction conditions	647:674	the best reaction conditions	647:674	It was established that for fructose dehydration, the best reaction conditions were the 160 °C as the optimized reaction temperature and 1 h reaction time, respectively.
33039532	4	1	theme	reaction	656:663	arg1	160 °C					685:690	the 160 °C	681:690	the 160 °C	681:690	It was established that for fructose dehydration, the best reaction conditions were the 160 °C as the optimized reaction temperature and 1 h reaction time, respectively.
33039532	0	2	theme	sugars	86:91	arg1	conversion					72:81	conversion	72:81	conversion of sugars to high-value added materials	72:121	Preparation of kapa carrageenan-based acidic heterogeneous catalyst for conversion of sugars to high-value added materials.
33039532	2	3	theme	glucose	340:346	arg1	dehydration					312:322	catalytic dehydration	302:322	catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA)	302:377	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	1	4	theme	crosslinking	234:245	arg1	agent					247:251	the crosslinking agent	230:251	the crosslinking agent	230:251	A novel composite based on kappa-Carrageenan (κC) was prepared using N,N-methylene bisacrylamide (MBA) as the crosslinking agent.
33039532	1	4	theme	crosslinking	234:245	arg1	N					193:193	N	193:193	N	193:193	A novel composite based on kappa-Carrageenan (κC) was prepared using N,N-methylene bisacrylamide (MBA) as the crosslinking agent.
33039532	0	5	theme	added	107:111	arg1	materials					113:121	high-value added materials	96:121	high-value added materials	96:121	Preparation of kapa carrageenan-based acidic heterogeneous catalyst for conversion of sugars to high-value added materials.
33039532	3	6	theme	quantity	515:522	arg1	optimization					495:506	optimization	495:506	optimization of the quantity of the catalyst, temperature, reaction time, and solvent	495:579	Various reaction parameters such as optimization of the quantity of the catalyst, temperature, reaction time, and solvent were performed.
33039532	3	7	theme	catalyst	531:538	arg1	quantity					515:522	the quantity	511:522	the quantity of the catalyst, temperature, reaction time, and solvent	511:579	Various reaction parameters such as optimization of the quantity of the catalyst, temperature, reaction time, and solvent were performed.
33039532	0	8	theme	high-value	96:105	arg1	materials					113:121	high-value added materials	96:121	high-value added materials	96:121	Preparation of kapa carrageenan-based acidic heterogeneous catalyst for conversion of sugars to high-value added materials.
33039532	2	9	from	groups	427:432	arg1	skeletons					448:456	biopolymer skeletons	437:456	biopolymer skeletons	437:456	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	4	10	theme	best	651:654	arg1	conditions					665:674	the best reaction conditions	647:674	the best reaction conditions	647:674	It was established that for fructose dehydration, the best reaction conditions were the 160 °C as the optimized reaction temperature and 1 h reaction time, respectively.
33039532	4	10	theme	best	651:654	arg1	160 °C					685:690	the 160 °C	681:690	the 160 °C	681:690	It was established that for fructose dehydration, the best reaction conditions were the 160 °C as the optimized reaction temperature and 1 h reaction time, respectively.
33039532	7	11	theme	glucose	1029:1035	arg1	yield					1019:1023	the HMF yield	1011:1023	the HMF yield	1011:1023	Under similar conditions, the HMF yield and glucose conversion are 47% and 93%, respectively.
33039532	7	11	theme	glucose	1029:1035	arg1	conversion					1037:1046	glucose conversion	1029:1046	glucose conversion	1029:1046	Under similar conditions, the HMF yield and glucose conversion are 47% and 93%, respectively.
33039532	7	11	theme	glucose	1029:1035	arg1	%					1054:1054	47%	1052:1054	47%	1052:1054	Under similar conditions, the HMF yield and glucose conversion are 47% and 93%, respectively.
33039532	5	12	theme	HMF	795:797	arg1	yield					799:803	the HMF yield	791:803	the HMF yield	791:803	Under these conditions, the HMF yield and fructose conversion were 94.2% and 95.5%, respectively.
33039532	5	12	theme	HMF	795:797	arg1	%					838:838	94.2%	834:838	94.2%	834:838	Under these conditions, the HMF yield and fructose conversion were 94.2% and 95.5%, respectively.
33039532	4	13	theme	reaction	738:745	arg1	time					747:750	1 h reaction time	734:750	1 h reaction time	734:750	It was established that for fructose dehydration, the best reaction conditions were the 160 °C as the optimized reaction temperature and 1 h reaction time, respectively.
33039532	5	14	theme	fructose	809:816	arg1	conversion					818:827	fructose conversion	809:827	fructose conversion	809:827	Under these conditions, the HMF yield and fructose conversion were 94.2% and 95.5%, respectively.
33039532	8	15	theme	considerable	1145:1156	arg1	reusability					1158:1168	considerable reusability	1145:1168	considerable reusability	1145:1168	The catalyst was readily prepared from inexpensive materials with considerable reusability and reactivity.
33039532	0	16	theme	heterogeneous	45:57	arg1	catalyst					59:66	acidic heterogeneous catalyst	38:66	acidic heterogeneous catalyst for conversion of sugars to high-value added materials	38:121	Preparation of kapa carrageenan-based acidic heterogeneous catalyst for conversion of sugars to high-value added materials.
33039532	4	17	theme	1 h	734:736	arg1	time					747:750	1 h reaction time	734:750	1 h reaction time	734:750	It was established that for fructose dehydration, the best reaction conditions were the 160 °C as the optimized reaction temperature and 1 h reaction time, respectively.
33039532	2	18	theme	sulfonic	413:420	arg1	groups					427:432	sulfonic acid groups	413:432	sulfonic acid groups in biopolymer skeletons	413:456	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	2	19	theme	catalytic	302:310	arg1	dehydration					312:322	catalytic dehydration	302:322	catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA)	302:377	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	6	20	theme	reaction	907:914	arg1	temperature					916:926	the best reaction temperature and reaction time	898:944	temperature	916:926	Furthermore, 160 °C and 2 h were the best reaction temperature and reaction time for glucose dehydration, respectively.
33039532	6	20	theme	reaction	907:914	arg1	2 h					889:891	2 h	889:891	2 h	889:891	Furthermore, 160 °C and 2 h were the best reaction temperature and reaction time for glucose dehydration, respectively.
33039532	6	20	theme	reaction	907:914	arg1	160 °C					878:883	160 °C	878:883	160 °C	878:883	Furthermore, 160 °C and 2 h were the best reaction temperature and reaction time for glucose dehydration, respectively.
33039532	3	21	theme	temperature	541:551	arg1	quantity					515:522	the quantity	511:522	the quantity of the catalyst, temperature, reaction time, and solvent	511:579	Various reaction parameters such as optimization of the quantity of the catalyst, temperature, reaction time, and solvent were performed.
33039532	4	22	theme	fructose	625:632	arg1	dehydration					634:644	fructose dehydration	625:644	fructose dehydration	625:644	It was established that for fructose dehydration, the best reaction conditions were the 160 °C as the optimized reaction temperature and 1 h reaction time, respectively.
33039532	2	23	theme	due	406:408	arg1	catalyst					397:404	the solid acid catalyst	382:404	the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons	382:456	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	2	23	theme	due	406:408	arg1	5-Hydroxymethylfurfural					254:276	5-Hydroxymethylfurfural	254:276	5-Hydroxymethylfurfural (5-HMF)	254:284	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	6	24	theme	best	902:905	arg1	temperature					916:926	the best reaction temperature and reaction time	898:944	temperature	916:926	Furthermore, 160 °C and 2 h were the best reaction temperature and reaction time for glucose dehydration, respectively.
33039532	6	24	theme	best	902:905	arg1	2 h					889:891	2 h	889:891	2 h	889:891	Furthermore, 160 °C and 2 h were the best reaction temperature and reaction time for glucose dehydration, respectively.
33039532	6	24	theme	best	902:905	arg1	160 °C					878:883	160 °C	878:883	160 °C	878:883	Furthermore, 160 °C and 2 h were the best reaction temperature and reaction time for glucose dehydration, respectively.
33039532	4	25	theme	reaction	709:716	arg1	temperature					718:728	the optimized reaction temperature	695:728	the optimized reaction temperature	695:728	It was established that for fructose dehydration, the best reaction conditions were the 160 °C as the optimized reaction temperature and 1 h reaction time, respectively.
33039532	2	26	theme	acid	392:395	arg1	catalyst					397:404	the solid acid catalyst	382:404	the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons	382:456	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	2	26	theme	acid	392:395	arg1	5-Hydroxymethylfurfural					254:276	5-Hydroxymethylfurfural	254:276	5-Hydroxymethylfurfural (5-HMF)	254:284	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	0	27	theme	kapa	15:18	arg1	Preparation					0:10	Preparation	0:10	Preparation of kapa	0:18	Preparation of kapa carrageenan-based acidic heterogeneous catalyst for conversion of sugars to high-value added materials.
33039532	7	28	theme	HMF	1015:1017	arg1	yield					1019:1023	the HMF yield	1011:1023	the HMF yield	1011:1023	Under similar conditions, the HMF yield and glucose conversion are 47% and 93%, respectively.
33039532	7	28	theme	HMF	1015:1017	arg1	conversion					1037:1046	glucose conversion	1029:1046	glucose conversion	1029:1046	Under similar conditions, the HMF yield and glucose conversion are 47% and 93%, respectively.
33039532	7	28	theme	HMF	1015:1017	arg1	%					1054:1054	47%	1052:1054	47%	1052:1054	Under similar conditions, the HMF yield and glucose conversion are 47% and 93%, respectively.
33039532	3	29	theme	reaction	467:474	arg1	parameters					476:485	Various reaction parameters	459:485	Various reaction parameters such as optimization of the quantity of the catalyst, temperature, reaction time, and solvent	459:579	Various reaction parameters such as optimization of the quantity of the catalyst, temperature, reaction time, and solvent were performed.
33039532	3	29	theme	reaction	467:474	arg1	optimization					495:506	optimization	495:506	optimization of the quantity of the catalyst, temperature, reaction time, and solvent	495:579	Various reaction parameters such as optimization of the quantity of the catalyst, temperature, reaction time, and solvent were performed.
33039532	2	30	theme	solid	386:390	arg1	catalyst					397:404	the solid acid catalyst	382:404	the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons	382:456	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	2	30	theme	solid	386:390	arg1	5-Hydroxymethylfurfural					254:276	5-Hydroxymethylfurfural	254:276	5-Hydroxymethylfurfural (5-HMF)	254:284	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	2	31	theme	biopolymer	437:446	arg1	skeletons					448:456	biopolymer skeletons	437:456	biopolymer skeletons	437:456	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	2	32	theme	fructose	327:334	arg1	dehydration					312:322	catalytic dehydration	302:322	catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA)	302:377	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	2	33	with	dehydration	312:322	arg1	κC-g-MBA					369:376	κC-g-MBA	369:376	κC-g-MBA	369:376	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	2	33	with	dehydration	312:322	arg1	κC					365:366	MBA grafted κC	353:366	MBA grafted κC (κC-g-MBA)	353:377	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	3	34	theme	time	563:566	arg1	quantity					515:522	the quantity	511:522	the quantity of the catalyst, temperature, reaction time, and solvent	511:579	Various reaction parameters such as optimization of the quantity of the catalyst, temperature, reaction time, and solvent were performed.
33039532	1	35	theme	N-methylene	195:205	arg1	MBA					222:224	MBA	222:224	MBA	222:224	A novel composite based on kappa-Carrageenan (κC) was prepared using N,N-methylene bisacrylamide (MBA) as the crosslinking agent.
33039532	1	35	theme	N-methylene	195:205	arg1	N					193:193	N	193:193	N	193:193	A novel composite based on kappa-Carrageenan (κC) was prepared using N,N-methylene bisacrylamide (MBA) as the crosslinking agent.
33039532	1	35	theme	N-methylene	195:205	arg1	bisacrylamide					207:219	N-methylene bisacrylamide	195:219	N-methylene bisacrylamide (MBA)	195:225	A novel composite based on kappa-Carrageenan (κC) was prepared using N,N-methylene bisacrylamide (MBA) as the crosslinking agent.
33039532	0	36	theme	acidic	38:43	arg1	catalyst					59:66	acidic heterogeneous catalyst	38:66	acidic heterogeneous catalyst for conversion of sugars to high-value added materials	38:121	Preparation of kapa carrageenan-based acidic heterogeneous catalyst for conversion of sugars to high-value added materials.
33039532	6	37	theme	reaction	932:939	arg1	time					941:944	the best reaction temperature and reaction time	898:944	time	941:944	Furthermore, 160 °C and 2 h were the best reaction temperature and reaction time for glucose dehydration, respectively.
33039532	8	38	theme	inexpensive	1118:1128	arg1	materials					1130:1138	inexpensive materials	1118:1138	inexpensive materials with considerable reusability and reactivity	1118:1183	The catalyst was readily prepared from inexpensive materials with considerable reusability and reactivity.
33039532	3	39	theme	Various	459:465	arg1	parameters					476:485	Various reaction parameters	459:485	Various reaction parameters such as optimization of the quantity of the catalyst, temperature, reaction time, and solvent	459:579	Various reaction parameters such as optimization of the quantity of the catalyst, temperature, reaction time, and solvent were performed.
33039532	3	39	theme	Various	459:465	arg1	optimization					495:506	optimization	495:506	optimization of the quantity of the catalyst, temperature, reaction time, and solvent	495:579	Various reaction parameters such as optimization of the quantity of the catalyst, temperature, reaction time, and solvent were performed.
33039532	2	40	theme	acid	422:425	arg1	groups					427:432	sulfonic acid groups	413:432	sulfonic acid groups in biopolymer skeletons	413:456	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	7	41	theme	similar	991:997	arg1	conditions					999:1008	similar conditions	991:1008	similar conditions	991:1008	Under similar conditions, the HMF yield and glucose conversion are 47% and 93%, respectively.
33039532	3	42	theme	reaction	554:561	arg1	time					563:566	reaction time	554:566	reaction time	554:566	Various reaction parameters such as optimization of the quantity of the catalyst, temperature, reaction time, and solvent were performed.
33039532	1	43	theme	novel	126:130	arg1	composite					132:140	A novel composite	124:140	A novel composite based on kappa-Carrageenan (κC)	124:172	A novel composite based on kappa-Carrageenan (κC) was prepared using N,N-methylene bisacrylamide (MBA) as the crosslinking agent.
33039532	4	44	theme	optimized	699:707	arg1	temperature					718:728	the optimized reaction temperature	695:728	the optimized reaction temperature	695:728	It was established that for fructose dehydration, the best reaction conditions were the 160 °C as the optimized reaction temperature and 1 h reaction time, respectively.
33039532	2	45	theme	grafted	357:363	arg1	κC-g-MBA					369:376	κC-g-MBA	369:376	κC-g-MBA	369:376	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	2	45	theme	grafted	357:363	arg1	κC					365:366	MBA grafted κC	353:366	MBA grafted κC (κC-g-MBA)	353:377	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	6	46	theme	glucose	950:956	arg1	dehydration					958:968	glucose dehydration	950:968	glucose dehydration	950:968	Furthermore, 160 °C and 2 h were the best reaction temperature and reaction time for glucose dehydration, respectively.
33039532	3	47	theme	solvent	573:579	arg1	quantity					515:522	the quantity	511:522	the quantity of the catalyst, temperature, reaction time, and solvent	511:579	Various reaction parameters such as optimization of the quantity of the catalyst, temperature, reaction time, and solvent were performed.
33039532	2	48	theme	MBA	353:355	arg1	κC-g-MBA					369:376	κC-g-MBA	369:376	κC-g-MBA	369:376	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
33039532	2	48	theme	MBA	353:355	arg1	κC					365:366	MBA grafted κC	353:366	MBA grafted κC (κC-g-MBA)	353:377	5-Hydroxymethylfurfural (5-HMF) was produced by catalytic dehydration of fructose and glucose with MBA grafted κC (κC-g-MBA) as the solid acid catalyst due to sulfonic acid groups in biopolymer skeletons.
32084477	0	0	theme	films	108:112	arg1	characterization					13:28	characterization	13:28	characterization	13:28	Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
32084477	0	0	theme	films	108:112	arg1	activity					48:55	antimicrobial activity	34:55	antimicrobial activity	34:55	Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
32084477	0	0	theme	films	108:112	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
32084477	5	1	theme	respective	1090:1099	arg1	EOs					1101:1103	respective EOs	1090:1103	respective EOs	1090:1103	The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs.
32084477	4	2	theme	PVA/GA/CS	819:827	arg1	films					829:833	PVA/GA/CS films	819:833	PVA/GA/CS films with and without BPEO and GEO	819:863	FTIR, XRD, SEM and DSC were performed with mechanical and antimicrobial properties of PVA/GA/CS films with and without BPEO and GEO.
32084477	8	3	theme	wound	1530:1534	arg1	dressing					1536:1543	wound dressing	1530:1543	wound dressing	1530:1543	The obtained results have demonstrated that both BPEO and GEO incorporated PVA/GA/CS films are promising alternatives to wound dressing and food packaging materials.
32084477	6	4	with	resistant	1170:1178	arg1	stability					1224:1232	improved heat stability	1210:1232	improved heat stability	1210:1232	The BPEO and GEO incorporated PVA/GA/CS films were considerable resistant to breakage and flexible with improved heat stability.
32084477	0	5	theme	composite	98:106	arg1	films					108:112	polyvinyl alcohol/gum arabic/chitosan composite films	60:112	polyvinyl alcohol/gum arabic/chitosan composite films	60:112	Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
32084477	5	6	theme	EOs	1101:1103	arg1	incorporation					1073:1085	the incorporation	1069:1085	the incorporation of respective EOs	1069:1103	The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs.
32084477	1	7	theme	Natural	185:191	arg1	materials					193:201	Natural materials	185:201	Natural materials	185:201	Natural materials have attracted increasing attention in wound dressing and food packaging process, which could overcome the serious environmental issues caused by conventional synthetic materials.
32084477	2	8	theme	biomedical	534:543	arg1	properties					545:554	their nutritional and biomedical properties	512:554	their nutritional and biomedical properties	512:554	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	1	9	dep	serious	310:316	arg1	environmental					318:330	environmental	318:330	environmental	318:330	Natural materials have attracted increasing attention in wound dressing and food packaging process, which could overcome the serious environmental issues caused by conventional synthetic materials.
32084477	7	10	dep	BPEO	1239:1242	arg1	The					1235:1237	The	1235:1237	The	1235:1237	The BPEO and GEO incorporated PVA/GA/CS films were significantly inhibited the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium.
32084477	8	11	dep	dressing	1536:1543	arg1	materials					1564:1572	materials	1564:1572	materials	1564:1572	The obtained results have demonstrated that both BPEO and GEO incorporated PVA/GA/CS films are promising alternatives to wound dressing and food packaging materials.
32084477	6	12	theme	GEO	1119:1121	arg1	films					1146:1150	The BPEO and GEO incorporated PVA/GA/CS films	1106:1150	The BPEO and GEO incorporated PVA/GA/CS films	1106:1150	The BPEO and GEO incorporated PVA/GA/CS films were considerable resistant to breakage and flexible with improved heat stability.
32084477	6	12	theme	GEO	1119:1121	arg1	resistant					1170:1178	resistant	1170:1178	resistant	1170:1178	The BPEO and GEO incorporated PVA/GA/CS films were considerable resistant to breakage and flexible with improved heat stability.
32084477	5	13	theme	due	1062:1064	arg1	coarseness					1051:1060	coarseness	1051:1060	coarseness due to the incorporation of respective EOs	1051:1103	The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs.
32084477	4	14	theme	films	829:833	arg1	properties					805:814	mechanical and antimicrobial properties	776:814	mechanical and antimicrobial properties of PVA/GA/CS films with and without BPEO and GEO	776:863	FTIR, XRD, SEM and DSC were performed with mechanical and antimicrobial properties of PVA/GA/CS films with and without BPEO and GEO.
32084477	5	15	contain	containing	939:948	arg2	entrapment					950:959	entrapment	950:959	entrapment of BPEO droplets	950:976	The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs.
32084477	5	15	contain	containing	939:948	arg1	cavities					930:937	cavities	930:937	cavities containing entrapment of BPEO droplets	930:976	The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs.
32084477	7	16	theme	typhimurium	1396:1406	arg1	growth					1314:1319	the growth	1310:1319	the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium	1310:1406	The BPEO and GEO incorporated PVA/GA/CS films were significantly inhibited the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium.
32084477	0	17	theme	pepper	138:143	arg1	oil					155:157	black pepper essential oil	132:157	black pepper essential oil	132:157	Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
32084477	7	18	theme	GEO	1248:1250	arg1	films					1275:1279	The BPEO and GEO incorporated PVA/GA/CS films	1235:1279	The BPEO and GEO incorporated PVA/GA/CS films	1235:1279	The BPEO and GEO incorporated PVA/GA/CS films were significantly inhibited the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium.
32084477	6	19	theme	PVA/GA/CS	1136:1144	arg1	films					1146:1150	The BPEO and GEO incorporated PVA/GA/CS films	1106:1150	The BPEO and GEO incorporated PVA/GA/CS films	1106:1150	The BPEO and GEO incorporated PVA/GA/CS films were considerable resistant to breakage and flexible with improved heat stability.
32084477	6	19	theme	PVA/GA/CS	1136:1144	arg1	resistant					1170:1178	resistant	1170:1178	resistant	1170:1178	The BPEO and GEO incorporated PVA/GA/CS films were considerable resistant to breakage and flexible with improved heat stability.
32084477	2	20	theme	essential	425:433	arg1	BPEO					440:443	BPEO	440:443	BPEO	440:443	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	2	20	theme	essential	425:433	arg1	oil					435:437	black pepper essential oil	412:437	black pepper essential oil (BPEO)	412:444	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	0	21	theme	black	132:136	arg1	oil					155:157	black pepper essential oil	132:157	black pepper essential oil	132:157	Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
32084477	4	22	theme	mechanical	776:785	arg1	properties					805:814	mechanical and antimicrobial properties	776:814	mechanical and antimicrobial properties of PVA/GA/CS films with and without BPEO and GEO	776:863	FTIR, XRD, SEM and DSC were performed with mechanical and antimicrobial properties of PVA/GA/CS films with and without BPEO and GEO.
32084477	6	23	theme	incorporated	1123:1134	arg1	films					1146:1150	The BPEO and GEO incorporated PVA/GA/CS films	1106:1150	The BPEO and GEO incorporated PVA/GA/CS films	1106:1150	The BPEO and GEO incorporated PVA/GA/CS films were considerable resistant to breakage and flexible with improved heat stability.
32084477	6	23	theme	incorporated	1123:1134	arg1	resistant					1170:1178	resistant	1170:1178	resistant	1170:1178	The BPEO and GEO incorporated PVA/GA/CS films were considerable resistant to breakage and flexible with improved heat stability.
32084477	2	24	theme	pepper	418:423	arg1	BPEO					440:443	BPEO	440:443	BPEO	440:443	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	2	24	theme	pepper	418:423	arg1	oil					435:437	black pepper essential oil	412:437	black pepper essential oil (BPEO)	412:444	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	3	25	theme	biocomposite	572:583	arg1	films					585:589	biocomposite films	572:589	biocomposite films based on polyvinyl alcohol (PVA), gum arabic (GA) and chitosan (CS) incorporated with BPEO and GEO	572:688	In this study, biocomposite films based on polyvinyl alcohol (PVA), gum arabic (GA) and chitosan (CS) incorporated with BPEO and GEO were fabricated by solvent casting method.
32084477	2	26	theme	black	412:416	arg1	BPEO					440:443	BPEO	440:443	BPEO	440:443	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	2	26	theme	black	412:416	arg1	oil					435:437	black pepper essential oil	412:437	black pepper essential oil (BPEO)	412:444	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	2	27	theme	essential	457:465	arg1	GEO					472:474	GEO	472:474	GEO	472:474	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	2	27	theme	essential	457:465	arg1	oil					467:469	ginger essential oil	450:469	ginger essential oil (GEO)	450:475	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	3	28	theme	solvent	709:715	arg1	method					725:730	solvent casting method	709:730	solvent casting method	709:730	In this study, biocomposite films based on polyvinyl alcohol (PVA), gum arabic (GA) and chitosan (CS) incorporated with BPEO and GEO were fabricated by solvent casting method.
32084477	4	29	theme	antimicrobial	791:803	arg1	properties					805:814	mechanical and antimicrobial properties	776:814	mechanical and antimicrobial properties of PVA/GA/CS films with and without BPEO and GEO	776:863	FTIR, XRD, SEM and DSC were performed with mechanical and antimicrobial properties of PVA/GA/CS films with and without BPEO and GEO.
32084477	1	30	theme	increasing	218:227	arg1	attention					229:237	increasing attention	218:237	increasing attention	218:237	Natural materials have attracted increasing attention in wound dressing and food packaging process, which could overcome the serious environmental issues caused by conventional synthetic materials.
32084477	2	31	theme	ginger	450:455	arg1	GEO					472:474	GEO	472:474	GEO	472:474	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	2	31	theme	ginger	450:455	arg1	oil					467:469	ginger essential oil	450:469	ginger essential oil (GEO)	450:475	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	1	32	theme	serious	310:316	arg1	issues					332:337	the serious environmental issues	306:337	the serious environmental issues caused by conventional synthetic materials	306:380	Natural materials have attracted increasing attention in wound dressing and food packaging process, which could overcome the serious environmental issues caused by conventional synthetic materials.
32084477	7	33	theme	cereus	1333:1338	arg1	growth					1314:1319	the growth	1310:1319	the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium	1310:1406	The BPEO and GEO incorporated PVA/GA/CS films were significantly inhibited the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium.
32084477	5	34	theme	heterogeneous	897:909	arg1	surface					917:923	heterogeneous rough surface	897:923	heterogeneous rough surface	897:923	The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs.
32084477	6	35	theme	improved	1210:1217	arg1	stability					1224:1232	improved heat stability	1210:1232	improved heat stability	1210:1232	The BPEO and GEO incorporated PVA/GA/CS films were considerable resistant to breakage and flexible with improved heat stability.
32084477	0	36	theme	essential	145:153	arg1	oil					155:157	black pepper essential oil	132:157	black pepper essential oil	132:157	Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
32084477	5	37	theme	rough	1032:1036	arg1	surface					1038:1044	heterogeneous rough surface	1018:1044	heterogeneous rough surface	1018:1044	The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs.
32084477	5	38	theme	rough	911:915	arg1	surface					917:923	heterogeneous rough surface	897:923	heterogeneous rough surface	897:923	The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs.
32084477	8	39	theme	incorporated	1471:1482	arg1	films					1494:1498	incorporated PVA/GA/CS films	1471:1498	incorporated PVA/GA/CS films	1471:1498	The obtained results have demonstrated that both BPEO and GEO incorporated PVA/GA/CS films are promising alternatives to wound dressing and food packaging materials.
32084477	7	40	theme	incorporated	1252:1263	arg1	films					1275:1279	The BPEO and GEO incorporated PVA/GA/CS films	1235:1279	The BPEO and GEO incorporated PVA/GA/CS films	1235:1279	The BPEO and GEO incorporated PVA/GA/CS films were significantly inhibited the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium.
32084477	0	41	theme	ginger	163:168	arg1	oil					180:182	ginger essential oil	163:182	ginger essential oil	163:182	Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
32084477	7	42	theme	PVA/GA/CS	1265:1273	arg1	films					1275:1279	The BPEO and GEO incorporated PVA/GA/CS films	1235:1279	The BPEO and GEO incorporated PVA/GA/CS films	1235:1279	The BPEO and GEO incorporated PVA/GA/CS films were significantly inhibited the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium.
32084477	3	43	theme	polyvinyl	600:608	arg1	PVA					619:621	PVA	619:621	PVA	619:621	In this study, biocomposite films based on polyvinyl alcohol (PVA), gum arabic (GA) and chitosan (CS) incorporated with BPEO and GEO were fabricated by solvent casting method.
32084477	3	43	theme	polyvinyl	600:608	arg1	CS					655:656	CS	655:656	CS	655:656	In this study, biocomposite films based on polyvinyl alcohol (PVA), gum arabic (GA) and chitosan (CS) incorporated with BPEO and GEO were fabricated by solvent casting method.
32084477	3	43	theme	polyvinyl	600:608	arg1	alcohol					610:616	polyvinyl alcohol	600:616	polyvinyl alcohol (PVA)	600:622	In this study, biocomposite films based on polyvinyl alcohol (PVA), gum arabic (GA) and chitosan (CS) incorporated with BPEO and GEO were fabricated by solvent casting method.
32084477	1	44	theme	wound	242:246	arg1	dressing					248:255	wound dressing and food packaging process	242:282	dressing	248:255	Natural materials have attracted increasing attention in wound dressing and food packaging process, which could overcome the serious environmental issues caused by conventional synthetic materials.
32084477	0	45	theme	antimicrobial	34:46	arg1	activity					48:55	antimicrobial activity	34:55	antimicrobial activity	34:55	Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
32084477	8	46	dep	BPEO	1458:1461	arg1	films					1494:1498	incorporated PVA/GA/CS films	1471:1498	incorporated PVA/GA/CS films	1471:1498	The obtained results have demonstrated that both BPEO and GEO incorporated PVA/GA/CS films are promising alternatives to wound dressing and food packaging materials.
32084477	3	47	theme	gum	625:627	arg1	GA					637:638	GA	637:638	GA	637:638	In this study, biocomposite films based on polyvinyl alcohol (PVA), gum arabic (GA) and chitosan (CS) incorporated with BPEO and GEO were fabricated by solvent casting method.
32084477	3	47	theme	gum	625:627	arg1	arabic					629:634	gum arabic	625:634	gum arabic (GA)	625:639	In this study, biocomposite films based on polyvinyl alcohol (PVA), gum arabic (GA) and chitosan (CS) incorporated with BPEO and GEO were fabricated by solvent casting method.
32084477	7	48	theme	coli	1376:1379	arg1	growth					1314:1319	the growth	1310:1319	the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium	1310:1406	The BPEO and GEO incorporated PVA/GA/CS films were significantly inhibited the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium.
32084477	0	49	theme	polyvinyl	60:68	arg1	films					108:112	polyvinyl alcohol/gum arabic/chitosan composite films	60:112	polyvinyl alcohol/gum arabic/chitosan composite films	60:112	Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
32084477	2	50	theme	nutritional	518:528	arg1	properties					545:554	their nutritional and biomedical properties	512:554	their nutritional and biomedical properties	512:554	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	3	51	theme	casting	717:723	arg1	method					725:730	solvent casting method	709:730	solvent casting method	709:730	In this study, biocomposite films based on polyvinyl alcohol (PVA), gum arabic (GA) and chitosan (CS) incorporated with BPEO and GEO were fabricated by solvent casting method.
32084477	7	52	theme	aureus	1356:1361	arg1	growth					1314:1319	the growth	1310:1319	the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium	1310:1406	The BPEO and GEO incorporated PVA/GA/CS films were significantly inhibited the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium.
32084477	6	53	theme	heat	1219:1222	arg1	stability					1224:1232	improved heat stability	1210:1232	improved heat stability	1210:1232	The BPEO and GEO incorporated PVA/GA/CS films were considerable resistant to breakage and flexible with improved heat stability.
32084477	8	54	theme	promising	1504:1512	arg1	BPEO					1458:1461	BPEO	1458:1461	BPEO	1458:1461	The obtained results have demonstrated that both BPEO and GEO incorporated PVA/GA/CS films are promising alternatives to wound dressing and food packaging materials.
32084477	8	54	theme	promising	1504:1512	arg1	alternatives					1514:1525	promising alternatives	1504:1525	promising alternatives to wound dressing and food packaging materials	1504:1572	The obtained results have demonstrated that both BPEO and GEO incorporated PVA/GA/CS films are promising alternatives to wound dressing and food packaging materials.
32084477	8	54	theme	promising	1504:1512	arg1	GEO					1467:1469	GEO	1467:1469	GEO	1467:1469	The obtained results have demonstrated that both BPEO and GEO incorporated PVA/GA/CS films are promising alternatives to wound dressing and food packaging materials.
32084477	1	55	theme	conventional	349:360	arg1	materials					372:380	conventional synthetic materials	349:380	conventional synthetic materials	349:380	Natural materials have attracted increasing attention in wound dressing and food packaging process, which could overcome the serious environmental issues caused by conventional synthetic materials.
32084477	0	56	theme	essential	170:178	arg1	oil					180:182	ginger essential oil	163:182	ginger essential oil	163:182	Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
32084477	5	57	theme	GEO-PVA/GA/CS	992:1004	arg1	film					1006:1009	the GEO-PVA/GA/CS film	988:1009	the GEO-PVA/GA/CS film	988:1009	The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs.
32084477	2	58	theme	Essential	383:391	arg1	oil					467:469	ginger essential oil	450:469	ginger essential oil (GEO)	450:475	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	2	58	theme	Essential	383:391	arg1	EOs					399:401	EOs	399:401	EOs	399:401	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	2	58	theme	Essential	383:391	arg1	oils					393:396	Essential oils	383:396	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO)	383:475	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	2	58	theme	Essential	383:391	arg1	oil					435:437	black pepper essential oil	412:437	black pepper essential oil (BPEO)	412:444	Essential oils (EOs) such as black pepper essential oil (BPEO) and ginger essential oil (GEO) have extensively been reported for their nutritional and biomedical properties.
32084477	1	59	theme	synthetic	362:370	arg1	materials					372:380	conventional synthetic materials	349:380	conventional synthetic materials	349:380	Natural materials have attracted increasing attention in wound dressing and food packaging process, which could overcome the serious environmental issues caused by conventional synthetic materials.
32084477	8	60	theme	obtained	1413:1420	arg1	results					1422:1428	The obtained results	1409:1428	The obtained results	1409:1428	The obtained results have demonstrated that both BPEO and GEO incorporated PVA/GA/CS films are promising alternatives to wound dressing and food packaging materials.
32084477	7	61	theme	BPEO	1239:1242	arg1	films					1275:1279	The BPEO and GEO incorporated PVA/GA/CS films	1235:1279	The BPEO and GEO incorporated PVA/GA/CS films	1235:1279	The BPEO and GEO incorporated PVA/GA/CS films were significantly inhibited the growth of Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium.
32084477	6	62	theme	BPEO	1110:1113	arg1	films					1146:1150	The BPEO and GEO incorporated PVA/GA/CS films	1106:1150	The BPEO and GEO incorporated PVA/GA/CS films	1106:1150	The BPEO and GEO incorporated PVA/GA/CS films were considerable resistant to breakage and flexible with improved heat stability.
32084477	6	62	theme	BPEO	1110:1113	arg1	resistant					1170:1178	resistant	1170:1178	resistant	1170:1178	The BPEO and GEO incorporated PVA/GA/CS films were considerable resistant to breakage and flexible with improved heat stability.
32084477	8	63	theme	PVA/GA/CS	1484:1492	arg1	films					1494:1498	incorporated PVA/GA/CS films	1471:1498	incorporated PVA/GA/CS films	1471:1498	The obtained results have demonstrated that both BPEO and GEO incorporated PVA/GA/CS films are promising alternatives to wound dressing and food packaging materials.
32084477	5	64	theme	BPEO-PVA/GA/CS	870:883	arg1	film					885:888	The BPEO-PVA/GA/CS film	866:888	The BPEO-PVA/GA/CS film	866:888	The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs.
32084477	1	65	theme	food	261:264	arg1	process					276:282	wound dressing and food packaging process	242:282	process	276:282	Natural materials have attracted increasing attention in wound dressing and food packaging process, which could overcome the serious environmental issues caused by conventional synthetic materials.
32084477	0	66	theme	arabic/chitosan	82:96	arg1	films					108:112	polyvinyl alcohol/gum arabic/chitosan composite films	60:112	polyvinyl alcohol/gum arabic/chitosan composite films	60:112	Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
32084477	5	67	theme	heterogeneous	1018:1030	arg1	surface					1038:1044	heterogeneous rough surface	1018:1044	heterogeneous rough surface	1018:1044	The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs.
32084477	5	68	theme	BPEO	964:967	arg1	droplets					969:976	BPEO droplets	964:976	BPEO droplets	964:976	The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs.
32084477	8	69	theme	food	1549:1552	arg1	packaging					1554:1562	food packaging	1549:1562	food packaging	1549:1562	The obtained results have demonstrated that both BPEO and GEO incorporated PVA/GA/CS films are promising alternatives to wound dressing and food packaging materials.
32084477	1	70	theme	packaging	266:274	arg1	process					276:282	wound dressing and food packaging process	242:282	process	276:282	Natural materials have attracted increasing attention in wound dressing and food packaging process, which could overcome the serious environmental issues caused by conventional synthetic materials.
32084477	0	71	theme	alcohol/gum	70:80	arg1	films					108:112	polyvinyl alcohol/gum arabic/chitosan composite films	60:112	polyvinyl alcohol/gum arabic/chitosan composite films	60:112	Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil.
32084477	5	72	theme	droplets	969:976	arg1	entrapment					950:959	entrapment	950:959	entrapment of BPEO droplets	950:976	The BPEO-PVA/GA/CS film showed heterogeneous rough surface with cavities containing entrapment of BPEO droplets, whereas, the GEO-PVA/GA/CS film showed heterogeneous rough surface with coarseness due to the incorporation of respective EOs.
34606791	2	0	theme	high	421:424	arg1	stability					426:434	high stability	421:434	high stability	421:434	The PS was characterized to contain 26.6% of amylose, exhibiting a "B"-type crystalline structure and high stability against thermal degradation.
34606791	1	1	theme	solvent	293:299	arg1	strategy					309:316	a solvent casting strategy	291:316	a solvent casting strategy	291:316	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	7	2	with	films	1109:1113	arg1	stability					1133:1141	good thermal stability	1120:1141	good thermal stability	1120:1141	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	1	3	with	combination	209:219	arg1	nanofiber					268:276	cellulose nanofiber	258:276	cellulose nanofiber (CNF)	258:282	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	1	3	with	combination	209:219	arg1	CNC					249:251	CNC	249:251	CNC	249:251	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	1	3	with	combination	209:219	arg1	CNF					279:281	CNF	279:281	CNF	279:281	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	1	3	with	combination	209:219	arg1	nanocrystal					236:246	cellulose nanocrystal	226:246	cellulose nanocrystal (CNC)	226:252	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	9	4	theme	food	1288:1291	arg1	applications					1303:1314	food packaging applications	1288:1314	food packaging applications	1288:1314	These films are expected to be especially useful in food packaging applications.
34606791	3	5	theme	films	620:624	arg1	strength					599:606	the tensile strength	587:606	the tensile strength (TS) of the films	587:624	PS/CNF films showed better thermal stability than PS/CNC films, whereas the CNC was more effective than CNF for enhancing the tensile strength (TS) of the films.
34606791	3	5	theme	films	620:624	arg1	TS					609:610	TS	609:610	TS	609:610	PS/CNF films showed better thermal stability than PS/CNC films, whereas the CNC was more effective than CNF for enhancing the tensile strength (TS) of the films.
34606791	0	6	from	effects	4:10	arg1	properties					68:77	the properties	64:77	the properties of pumpkin	64:88	The effects of cellulose nanocrystal and cellulose nanofiber on the properties of pumpkin starch-based composite films.
34606791	6	7	theme	films	908:912	arg1	transparency					889:900	the transparency	885:900	the transparency of PS films	885:912	CNC and CNF both decreased the transparency of PS films, by 5.2% and 13.1%, respectively.
34606791	7	8	theme	films	988:992	arg1	properties					961:970	the properties	957:970	the properties of PS composite films	957:992	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	3	9	theme	better	485:490	arg1	stability					500:508	better thermal stability	485:508	better thermal stability	485:508	PS/CNF films showed better thermal stability than PS/CNC films, whereas the CNC was more effective than CNF for enhancing the tensile strength (TS) of the films.
34606791	6	10	theme	PS	905:906	arg1	films					908:912	PS films	905:912	PS films	905:912	CNC and CNF both decreased the transparency of PS films, by 5.2% and 13.1%, respectively.
34606791	0	11	theme	pumpkin	82:88	arg1	properties					68:77	the properties	64:77	the properties of pumpkin	64:88	The effects of cellulose nanocrystal and cellulose nanofiber on the properties of pumpkin starch-based composite films.
34606791	8	12	theme	CNC/CNF	1200:1206	arg1	fabrication					1223:1233	CNC/CNF composite film fabrication	1200:1233	CNC/CNF composite film fabrication	1200:1233	Our results indicate that PS is a suitable material for CNC/CNF composite film fabrication.
34606791	3	13	theme	thermal	492:498	arg1	stability					500:508	better thermal stability	485:508	better thermal stability	485:508	PS/CNF films showed better thermal stability than PS/CNC films, whereas the CNC was more effective than CNF for enhancing the tensile strength (TS) of the films.
34606791	9	14	theme	packaging	1293:1301	arg1	applications					1303:1314	food packaging applications	1288:1314	food packaging applications	1288:1314	These films are expected to be especially useful in food packaging applications.
34606791	7	15	theme	PS/CNC	1055:1060	arg1	CNF					1047:1049	CNF	1047:1049	CNF	1047:1049	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	7	15	theme	PS/CNC	1055:1060	arg1	CNC					1039:1041	CNC	1039:1041	CNC	1039:1041	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	7	15	theme	PS/CNC	1055:1060	arg1	films					1062:1066	PS/CNC films	1055:1066	PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability	1055:1141	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	5	16	theme	hydrogen	758:765	arg1	bonding					767:773	stronger hydrogen bonding	749:773	stronger hydrogen bonding	749:773	Fourier transform infrared spectra revealed stronger hydrogen bonding in the PS/CNC films, likely contributing to the observed high mechanical strength.
34606791	4	17	theme	1	662:662	arg1	%					663:663	%	663:663	%	663:663	The nanocomposite films containing 1% CNC showed the highest TS of 30.32 MPa.
34606791	7	18	theme	PS	975:976	arg1	films					988:992	PS composite films	975:992	PS composite films	975:992	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	0	19	theme	composite	103:111	arg1	films					113:117	composite films	103:117	composite films	103:117	The effects of cellulose nanocrystal and cellulose nanofiber on the properties of pumpkin starch-based composite films.
34606791	5	20	dep	Fourier	705:711	arg1	transform					713:721	transform	713:721	transform infrared spectra	713:738	Fourier transform infrared spectra revealed stronger hydrogen bonding in the PS/CNC films, likely contributing to the observed high mechanical strength.
34606791	4	21	theme	highest	680:686	arg1	TS					688:689	the highest TS	676:689	the highest TS of 30.32 MPa	676:702	The nanocomposite films containing 1% CNC showed the highest TS of 30.32 MPa.
34606791	1	22	theme	Cucurbita	159:167	arg1	maxima					169:174	Cucurbita maxima	159:174	Cucurbita maxima	159:174	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	3	23	theme	PS/CNC	515:520	arg1	films					522:526	PS/CNC films	515:526	PS/CNC films	515:526	PS/CNF films showed better thermal stability than PS/CNC films, whereas the CNC was more effective than CNF for enhancing the tensile strength (TS) of the films.
34606791	1	24	theme	casting	301:307	arg1	strategy					309:316	a solvent casting strategy	291:316	a solvent casting strategy	291:316	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	5	25	theme	infrared	723:730	arg1	spectra					732:738	infrared spectra	723:738	infrared spectra	723:738	Fourier transform infrared spectra revealed stronger hydrogen bonding in the PS/CNC films, likely contributing to the observed high mechanical strength.
34606791	0	26	theme	cellulose	15:23	arg1	nanocrystal					25:35	cellulose nanocrystal	15:35	cellulose nanocrystal	15:35	The effects of cellulose nanocrystal and cellulose nanofiber on the properties of pumpkin starch-based composite films.
34606791	1	27	theme	cellulose	258:266	arg1	nanofiber					268:276	cellulose nanofiber	258:276	cellulose nanofiber (CNF)	258:282	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	1	27	theme	cellulose	258:266	arg1	CNF					279:281	CNF	279:281	CNF	279:281	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	7	28	theme	composite	978:986	arg1	films					988:992	PS composite films	975:992	PS composite films	975:992	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	5	29	theme	stronger	749:756	arg1	bonding					767:773	stronger hydrogen bonding	749:773	stronger hydrogen bonding	749:773	Fourier transform infrared spectra revealed stronger hydrogen bonding in the PS/CNC films, likely contributing to the observed high mechanical strength.
34606791	4	30	contain	containing	651:660	arg2	CNC					665:667	1% CNC	662:667	1% CNC	662:667	The nanocomposite films containing 1% CNC showed the highest TS of 30.32 MPa.
34606791	4	30	contain	containing	651:660	arg1	films					645:649	The nanocomposite films	627:649	The nanocomposite films containing 1% CNC	627:667	The nanocomposite films containing 1% CNC showed the highest TS of 30.32 MPa.
34606791	4	31	theme	%	663:663	arg1	CNC					665:667	1% CNC	662:667	1% CNC	662:667	The nanocomposite films containing 1% CNC showed the highest TS of 30.32 MPa.
34606791	2	32	theme	amylose	364:370	arg1	amylose					364:370	amylose	364:370	amylose	364:370	The PS was characterized to contain 26.6% of amylose, exhibiting a "B"-type crystalline structure and high stability against thermal degradation.
34606791	2	32	theme	amylose	364:370	arg1	%					359:359	26.6%	355:359	26.6% of amylose	355:370	The PS was characterized to contain 26.6% of amylose, exhibiting a "B"-type crystalline structure and high stability against thermal degradation.
34606791	8	33	theme	film	1218:1221	arg1	fabrication					1223:1233	CNC/CNF composite film fabrication	1200:1233	CNC/CNF composite film fabrication	1200:1233	Our results indicate that PS is a suitable material for CNC/CNF composite film fabrication.
34606791	3	34	dep	showed	478:483	arg1	whereas					529:535	whereas	529:535	whereas	529:535	PS/CNF films showed better thermal stability than PS/CNC films, whereas the CNC was more effective than CNF for enhancing the tensile strength (TS) of the films.
34606791	9	35	from	useful	1278:1283	arg1	applications					1303:1314	food packaging applications	1288:1314	food packaging applications	1288:1314	These films are expected to be especially useful in food packaging applications.
34606791	8	36	theme	suitable	1178:1185	arg1	PS					1170:1171	PS	1170:1171	PS	1170:1171	Our results indicate that PS is a suitable material for CNC/CNF composite film fabrication.
34606791	8	36	theme	suitable	1178:1185	arg1	material					1187:1194	a suitable material	1176:1194	a suitable material for CNC/CNF composite film fabrication	1176:1233	Our results indicate that PS is a suitable material for CNC/CNF composite film fabrication.
34606791	0	37	theme	nanocrystal	25:35	arg1	effects					4:10	The effects	0:10	The effects of cellulose nanocrystal and cellulose nanofiber on the properties of pumpkin	0:88	The effects of cellulose nanocrystal and cellulose nanofiber on the properties of pumpkin starch-based composite films.
34606791	2	38	theme	crystalline	395:405	arg1	structure					407:415	a "B"-type crystalline structure	384:415	a "B"-type crystalline structure	384:415	The PS was characterized to contain 26.6% of amylose, exhibiting a "B"-type crystalline structure and high stability against thermal degradation.
34606791	2	39	contain	contain	347:353	arg2	amylose					364:370	amylose	364:370	amylose	364:370	The PS was characterized to contain 26.6% of amylose, exhibiting a "B"-type crystalline structure and high stability against thermal degradation.
34606791	2	39	contain	contain	347:353	arg1	PS					323:324	The PS	319:324	The PS	319:324	The PS was characterized to contain 26.6% of amylose, exhibiting a "B"-type crystalline structure and high stability against thermal degradation.
34606791	2	39	contain	contain	347:353	arg2	%					359:359	26.6%	355:359	26.6% of amylose	355:370	The PS was characterized to contain 26.6% of amylose, exhibiting a "B"-type crystalline structure and high stability against thermal degradation.
34606791	5	40	theme	high	832:835	arg1	strength					848:855	the observed high mechanical strength	819:855	the observed high mechanical strength	819:855	Fourier transform infrared spectra revealed stronger hydrogen bonding in the PS/CNC films, likely contributing to the observed high mechanical strength.
34606791	2	41	theme	thermal	444:450	arg1	degradation					452:462	thermal degradation	444:462	thermal degradation	444:462	The PS was characterized to contain 26.6% of amylose, exhibiting a "B"-type crystalline structure and high stability against thermal degradation.
34606791	2	42	theme	-type	389:393	arg1	structure					407:415	a "B"-type crystalline structure	384:415	a "B"-type crystalline structure	384:415	The PS was characterized to contain 26.6% of amylose, exhibiting a "B"-type crystalline structure and high stability against thermal degradation.
34606791	8	43	theme	composite	1208:1216	arg1	fabrication					1223:1233	CNC/CNF composite film fabrication	1200:1233	CNC/CNF composite film fabrication	1200:1233	Our results indicate that PS is a suitable material for CNC/CNF composite film fabrication.
34606791	7	44	theme	PS/CNF	1102:1107	arg1	films					1109:1113	PS/CNF films	1102:1113	PS/CNF films with good thermal stability	1102:1141	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	5	45	theme	observed	823:830	arg1	strength					848:855	the observed high mechanical strength	819:855	the observed high mechanical strength	819:855	Fourier transform infrared spectra revealed stronger hydrogen bonding in the PS/CNC films, likely contributing to the observed high mechanical strength.
34606791	0	46	theme	cellulose	41:49	arg1	nanofiber					51:59	cellulose nanofiber	41:59	cellulose nanofiber	41:59	The effects of cellulose nanocrystal and cellulose nanofiber on the properties of pumpkin starch-based composite films.
34606791	1	47	used	utilized	180:187	arg2	PS					136:137	PS	136:137	PS	136:137	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	1	47	used	utilized	180:187	arg2	starch					128:133	Pumpkin starch	120:133	Pumpkin starch (PS)	120:138	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	7	48	theme	high	1073:1076	arg1	strength					1089:1096	high mechanical strength	1073:1096	high mechanical strength	1073:1096	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	1	49	theme	Pumpkin	120:126	arg1	starch					128:133	Pumpkin starch	120:133	Pumpkin starch (PS)	120:138	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	1	49	theme	Pumpkin	120:126	arg1	PS					136:137	PS	136:137	PS	136:137	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	7	50	theme	thermal	1125:1131	arg1	stability					1133:1141	good thermal stability	1120:1141	good thermal stability	1120:1141	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	4	51	theme	30.32 MPa	694:702	arg1	TS					688:689	the highest TS	676:689	the highest TS of 30.32 MPa	676:702	The nanocomposite films containing 1% CNC showed the highest TS of 30.32 MPa.
34606791	7	52	with	films	1062:1066	arg1	strength					1089:1096	high mechanical strength	1073:1096	high mechanical strength	1073:1096	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	7	52	with	films	1062:1066	arg1	films					1109:1113	PS/CNF films	1102:1113	PS/CNF films with good thermal stability	1102:1141	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	5	53	theme	mechanical	837:846	arg1	strength					848:855	the observed high mechanical strength	819:855	the observed high mechanical strength	819:855	Fourier transform infrared spectra revealed stronger hydrogen bonding in the PS/CNC films, likely contributing to the observed high mechanical strength.
34606791	7	54	theme	mechanical	1078:1087	arg1	strength					1089:1096	high mechanical strength	1073:1096	high mechanical strength	1073:1096	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	3	55	theme	tensile	591:597	arg1	strength					599:606	the tensile strength	587:606	the tensile strength (TS) of the films	587:624	PS/CNF films showed better thermal stability than PS/CNC films, whereas the CNC was more effective than CNF for enhancing the tensile strength (TS) of the films.
34606791	3	55	theme	tensile	591:597	arg1	TS					609:610	TS	609:610	TS	609:610	PS/CNF films showed better thermal stability than PS/CNC films, whereas the CNC was more effective than CNF for enhancing the tensile strength (TS) of the films.
34606791	7	56	with	strength	1089:1096	arg1	stability					1133:1141	good thermal stability	1120:1141	good thermal stability	1120:1141	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	4	57	theme	nanocomposite	631:643	arg1	films					645:649	The nanocomposite films	627:649	The nanocomposite films containing 1% CNC	627:667	The nanocomposite films containing 1% CNC showed the highest TS of 30.32 MPa.
34606791	7	58	theme	good	1120:1123	arg1	stability					1133:1141	good thermal stability	1120:1141	good thermal stability	1120:1141	Overall, the properties of PS composite films can be effectively modified by incorporating CNC and CNF, as PS/CNC films with high mechanical strength and PS/CNF films with good thermal stability.
34606791	5	59	theme	PS/CNC	782:787	arg1	films					789:793	the PS/CNC films	778:793	the PS/CNC films	778:793	Fourier transform infrared spectra revealed stronger hydrogen bonding in the PS/CNC films, likely contributing to the observed high mechanical strength.
34606791	0	60	theme	nanofiber	51:59	arg1	effects					4:10	The effects	0:10	The effects of cellulose nanocrystal and cellulose nanofiber on the properties of pumpkin	0:88	The effects of cellulose nanocrystal and cellulose nanofiber on the properties of pumpkin starch-based composite films.
34606791	9	61	from	applications	1303:1314	arg1	useful					1278:1283	useful	1278:1283	useful	1278:1283	These films are expected to be especially useful in food packaging applications.
34606791	3	62	theme	PS/CNF	465:470	arg1	films					472:476	PS/CNF films	465:476	PS/CNF films	465:476	PS/CNF films showed better thermal stability than PS/CNC films, whereas the CNC was more effective than CNF for enhancing the tensile strength (TS) of the films.
34606791	1	63	theme	cellulose	226:234	arg1	CNC					249:251	CNC	249:251	CNC	249:251	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
34606791	1	63	theme	cellulose	226:234	arg1	nanocrystal					236:246	cellulose nanocrystal	226:246	cellulose nanocrystal (CNC)	226:252	Pumpkin starch (PS) was extracted from Cucurbita maxima and utilized to prepare films in combination with cellulose nanocrystal (CNC) and cellulose nanofiber (CNF), using a solvent casting strategy.
32924327	7	0	theme	time-resolved	1109:1121	arg1	profiles					1123:1130	time-resolved profiles	1109:1130	time-resolved profiles of human plasma coronas formed on functionalized GET-MNPs	1109:1188	Using label-free snapshot proteomics, time-resolved profiles of human plasma coronas formed on functionalized GET-MNPs demonstrate that coronae quickly form (<1 min), with their composition relatively stable but evolving.
32924327	1	1	theme	biomedical	157:166	arg1	Nanoparticles					101:113	Nanoparticles	101:113	Nanoparticles (NPs)	101:119	Nanoparticles (NPs) are increasingly being developed as biomedical platforms for drug/nucleic acid delivery and imaging.
32924327	1	1	theme	biomedical	157:166	arg1	platforms					168:176	biomedical platforms	157:176	biomedical platforms for drug/nucleic acid delivery and imaging	157:219	Nanoparticles (NPs) are increasingly being developed as biomedical platforms for drug/nucleic acid delivery and imaging.
32924327	6	2	theme	NP	972:973	arg1	stability					985:993	NP colloidal stability	972:993	NP colloidal stability	972:993	NP colloidal stability, physicochemical properties, toxicity and cellular uptake are investigated.
32924327	0	3	theme	Protein	84:90	arg1	Coronas					92:98	Rapidly Forming Plasma Protein Coronas	61:98	Rapidly Forming Plasma Protein Coronas	61:98	Enhanced Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas.
32924327	9	4	theme	cell-type	1572:1580	arg1	targeting					1591:1599	cell-type specific targeting	1572:1599	cell-type specific targeting of new nanomaterials	1572:1620	Understanding how NPs interact with biological systems and can retain enhanced intracellular transduction will facilitate novel drug delivery approaches for cell-type specific targeting of new nanomaterials.
32924327	8	5	with	consistent	1375:1384	arg1	activities					1403:1412	GAG-binding activities	1391:1412	GAG-binding activities	1391:1412	Importantly GET-MNPs present a subtly different corona composition to MNPs alone, consistent with GAG-binding activities.
32924327	5	6	theme	intracellular	880:892	arg1	transduction					894:905	sustained intracellular transduction	870:905	sustained intracellular transduction of magnetic NPs (MNPs)	870:928	Herein, it is demonstrated that GET peptide coatings can mediate sustained intracellular transduction of magnetic NPs (MNPs), even in the presence of serum or plasma.
32924327	4	7	theme	penetrating	729:739	arg1	CPPs					751:754	CPPs	751:754	CPPs	751:754	Glycosaminoglycan (GAG)-binding enhanced transduction (GET) is developed to efficiently deliver a variety of cargoes intracellularly; employing GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs) which enhance endocytotic cell internalization.
32924327	4	7	theme	penetrating	729:739	arg1	peptides					741:748	cell penetrating peptides	724:748	cell penetrating peptides (CPPs)	724:755	Glycosaminoglycan (GAG)-binding enhanced transduction (GET) is developed to efficiently deliver a variety of cargoes intracellularly; employing GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs) which enhance endocytotic cell internalization.
32924327	9	8	theme	nanomaterials	1608:1620	arg1	targeting					1591:1599	cell-type specific targeting	1572:1599	cell-type specific targeting of new nanomaterials	1572:1620	Understanding how NPs interact with biological systems and can retain enhanced intracellular transduction will facilitate novel drug delivery approaches for cell-type specific targeting of new nanomaterials.
32924327	8	9	theme	corona	1341:1346	arg1	composition					1348:1358	a subtly different corona composition	1322:1358	a subtly different corona composition	1322:1358	Importantly GET-MNPs present a subtly different corona composition to MNPs alone, consistent with GAG-binding activities.
32924327	7	10	theme	plasma	1141:1146	arg1	coronas					1148:1154	human plasma coronas	1135:1154	human plasma coronas formed on functionalized GET-MNPs	1135:1188	Using label-free snapshot proteomics, time-resolved profiles of human plasma coronas formed on functionalized GET-MNPs demonstrate that coronae quickly form (<1 min), with their composition relatively stable but evolving.
32924327	3	11	theme	general	487:493	arg1	uptake					516:521	general or specific cellular uptake	487:521	general or specific cellular uptake	487:521	Coronae can critically influence self-interaction and binding of other molecules, which can affect toxicity, promote cell activation, and inhibit general or specific cellular uptake.
32924327	9	12	theme	drug	1543:1546	arg1	approaches					1557:1566	novel drug delivery approaches	1537:1566	novel drug delivery approaches for cell-type specific targeting of new nanomaterials	1537:1620	Understanding how NPs interact with biological systems and can retain enhanced intracellular transduction will facilitate novel drug delivery approaches for cell-type specific targeting of new nanomaterials.
32924327	4	13	theme	cell	704:707	arg1	targeting					709:717	cell targeting	704:717	cell targeting	704:717	Glycosaminoglycan (GAG)-binding enhanced transduction (GET) is developed to efficiently deliver a variety of cargoes intracellularly; employing GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs) which enhance endocytotic cell internalization.
32924327	7	14	theme	label-free	1077:1086	arg1	proteomics					1097:1106	label-free snapshot proteomics	1077:1106	label-free snapshot proteomics	1077:1106	Using label-free snapshot proteomics, time-resolved profiles of human plasma coronas formed on functionalized GET-MNPs demonstrate that coronae quickly form (<1 min), with their composition relatively stable but evolving.
32924327	5	15	dep	serum	955:959	arg1	presence					943:950	presence	943:950	presence	943:950	Herein, it is demonstrated that GET peptide coatings can mediate sustained intracellular transduction of magnetic NPs (MNPs), even in the presence of serum or plasma.
32924327	5	15	dep	serum	955:959	arg1	the					939:941	the	939:941	the	939:941	Herein, it is demonstrated that GET peptide coatings can mediate sustained intracellular transduction of magnetic NPs (MNPs), even in the presence of serum or plasma.
32924327	2	16	theme	wide	273:276	arg1	range					278:282	a wide range	271:282	a wide range of proteins that form a coating known as protein corona	271:338	However, in biological fluids, NPs interact with a wide range of proteins that form a coating known as protein corona.
32924327	5	17	theme	peptide	841:847	arg1	coatings					849:856	GET peptide coatings	837:856	GET peptide coatings	837:856	Herein, it is demonstrated that GET peptide coatings can mediate sustained intracellular transduction of magnetic NPs (MNPs), even in the presence of serum or plasma.
32924327	3	18	theme	other	406:410	arg1	molecules					412:420	other molecules	406:420	other molecules	406:420	Coronae can critically influence self-interaction and binding of other molecules, which can affect toxicity, promote cell activation, and inhibit general or specific cellular uptake.
32924327	9	19	theme	new	1604:1606	arg1	nanomaterials					1608:1620	new nanomaterials	1604:1620	new nanomaterials	1604:1620	Understanding how NPs interact with biological systems and can retain enhanced intracellular transduction will facilitate novel drug delivery approaches for cell-type specific targeting of new nanomaterials.
32924327	1	20	theme	drug/nucleic	182:193	arg1	delivery					200:207	drug/nucleic acid delivery	182:207	drug/nucleic acid delivery	182:207	Nanoparticles (NPs) are increasingly being developed as biomedical platforms for drug/nucleic acid delivery and imaging.
32924327	0	21	theme	Cellular	9:16	arg1	Transduction					18:29	Cellular Transduction	9:29	Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas	9:98	Enhanced Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas.
32924327	4	22	theme	cell	724:727	arg1	CPPs					751:754	CPPs	751:754	CPPs	751:754	Glycosaminoglycan (GAG)-binding enhanced transduction (GET) is developed to efficiently deliver a variety of cargoes intracellularly; employing GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs) which enhance endocytotic cell internalization.
32924327	4	22	theme	cell	724:727	arg1	peptides					741:748	cell penetrating peptides	724:748	cell penetrating peptides (CPPs)	724:755	Glycosaminoglycan (GAG)-binding enhanced transduction (GET) is developed to efficiently deliver a variety of cargoes intracellularly; employing GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs) which enhance endocytotic cell internalization.
32924327	7	23	theme	functionalized	1166:1179	arg1	GET-MNPs					1181:1188	functionalized GET-MNPs	1166:1188	functionalized GET-MNPs	1166:1188	Using label-free snapshot proteomics, time-resolved profiles of human plasma coronas formed on functionalized GET-MNPs demonstrate that coronae quickly form (<1 min), with their composition relatively stable but evolving.
32924327	1	24	theme	acid	195:198	arg1	delivery					200:207	drug/nucleic acid delivery	182:207	drug/nucleic acid delivery	182:207	Nanoparticles (NPs) are increasingly being developed as biomedical platforms for drug/nucleic acid delivery and imaging.
32924327	7	25	theme	coronas	1148:1154	arg1	profiles					1123:1130	time-resolved profiles	1109:1130	time-resolved profiles of human plasma coronas formed on functionalized GET-MNPs	1109:1188	Using label-free snapshot proteomics, time-resolved profiles of human plasma coronas formed on functionalized GET-MNPs demonstrate that coronae quickly form (<1 min), with their composition relatively stable but evolving.
32924327	6	26	theme	cellular	1037:1044	arg1	uptake					1046:1051	cellular uptake	1037:1051	cellular uptake	1037:1051	NP colloidal stability, physicochemical properties, toxicity and cellular uptake are investigated.
32924327	7	27	dep	form	1223:1226	arg1	min					1232:1234	<1 min	1229:1234	<1 min	1229:1234	Using label-free snapshot proteomics, time-resolved profiles of human plasma coronas formed on functionalized GET-MNPs demonstrate that coronae quickly form (<1 min), with their composition relatively stable but evolving.
32924327	9	28	theme	biological	1451:1460	arg1	systems					1462:1468	biological systems	1451:1468	biological systems	1451:1468	Understanding how NPs interact with biological systems and can retain enhanced intracellular transduction will facilitate novel drug delivery approaches for cell-type specific targeting of new nanomaterials.
32924327	7	29	theme	snapshot	1088:1095	arg1	proteomics					1097:1106	label-free snapshot proteomics	1077:1106	label-free snapshot proteomics	1077:1106	Using label-free snapshot proteomics, time-resolved profiles of human plasma coronas formed on functionalized GET-MNPs demonstrate that coronae quickly form (<1 min), with their composition relatively stable but evolving.
32924327	9	30	theme	enhanced	1485:1492	arg1	transduction					1508:1519	enhanced intracellular transduction	1485:1519	enhanced intracellular transduction	1485:1519	Understanding how NPs interact with biological systems and can retain enhanced intracellular transduction will facilitate novel drug delivery approaches for cell-type specific targeting of new nanomaterials.
32924327	4	31	theme	enhanced	556:563	arg1	transduction					565:576	Glycosaminoglycan (GAG)-binding enhanced transduction	524:576	Glycosaminoglycan (GAG)-binding enhanced transduction (GET)	524:582	Glycosaminoglycan (GAG)-binding enhanced transduction (GET) is developed to efficiently deliver a variety of cargoes intracellularly; employing GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs) which enhance endocytotic cell internalization.
32924327	2	32	theme	proteins	287:294	arg1	range					278:282	a wide range	271:282	a wide range of proteins that form a coating known as protein corona	271:338	However, in biological fluids, NPs interact with a wide range of proteins that form a coating known as protein corona.
32924327	3	33	theme	cell	458:461	arg1	activation					463:472	cell activation	458:472	cell activation	458:472	Coronae can critically influence self-interaction and binding of other molecules, which can affect toxicity, promote cell activation, and inhibit general or specific cellular uptake.
32924327	0	34	theme	Resistant	48:56	arg1	Nanoparticles					34:46	Nanoparticles	34:46	Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas	34:98	Enhanced Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas.
32924327	4	35	theme	-binding	547:554	arg1	transduction					565:576	Glycosaminoglycan (GAG)-binding enhanced transduction	524:576	Glycosaminoglycan (GAG)-binding enhanced transduction (GET)	524:582	Glycosaminoglycan (GAG)-binding enhanced transduction (GET) is developed to efficiently deliver a variety of cargoes intracellularly; employing GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs) which enhance endocytotic cell internalization.
32924327	9	36	theme	intracellular	1494:1506	arg1	transduction					1508:1519	enhanced intracellular transduction	1485:1519	enhanced intracellular transduction	1485:1519	Understanding how NPs interact with biological systems and can retain enhanced intracellular transduction will facilitate novel drug delivery approaches for cell-type specific targeting of new nanomaterials.
32924327	7	37	theme	evolving	1283:1290	arg1	composition					1249:1259	their composition	1243:1259	their composition relatively stable but evolving	1243:1290	Using label-free snapshot proteomics, time-resolved profiles of human plasma coronas formed on functionalized GET-MNPs demonstrate that coronae quickly form (<1 min), with their composition relatively stable but evolving.
32924327	0	38	theme	Nanoparticles	34:46	arg1	Transduction					18:29	Cellular Transduction	9:29	Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas	9:98	Enhanced Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas.
32924327	3	39	theme	molecules	412:420	arg1	self-interaction					374:389	self-interaction	374:389	self-interaction	374:389	Coronae can critically influence self-interaction and binding of other molecules, which can affect toxicity, promote cell activation, and inhibit general or specific cellular uptake.
32924327	3	39	theme	molecules	412:420	arg1	binding					395:401	binding	395:401	binding	395:401	Coronae can critically influence self-interaction and binding of other molecules, which can affect toxicity, promote cell activation, and inhibit general or specific cellular uptake.
32924327	2	40	theme	biological	234:243	arg1	fluids					245:250	biological fluids	234:250	biological fluids	234:250	However, in biological fluids, NPs interact with a wide range of proteins that form a coating known as protein corona.
32924327	5	41	theme	sustained	870:878	arg1	transduction					894:905	sustained intracellular transduction	870:905	sustained intracellular transduction of magnetic NPs (MNPs)	870:928	Herein, it is demonstrated that GET peptide coatings can mediate sustained intracellular transduction of magnetic NPs (MNPs), even in the presence of serum or plasma.
32924327	4	42	dep	transduction	565:576	arg1	GET					579:581	GET	579:581	GET	579:581	Glycosaminoglycan (GAG)-binding enhanced transduction (GET) is developed to efficiently deliver a variety of cargoes intracellularly; employing GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs) which enhance endocytotic cell internalization.
32924327	2	43	theme	protein	325:331	arg1	corona					333:338	protein corona	325:338	protein corona	325:338	However, in biological fluids, NPs interact with a wide range of proteins that form a coating known as protein corona.
32924327	7	44	theme	human	1135:1139	arg1	coronas					1148:1154	human plasma coronas	1135:1154	human plasma coronas formed on functionalized GET-MNPs	1135:1188	Using label-free snapshot proteomics, time-resolved profiles of human plasma coronas formed on functionalized GET-MNPs demonstrate that coronae quickly form (<1 min), with their composition relatively stable but evolving.
32924327	5	45	dep	coatings	849:856	arg1	GET					837:839	GET	837:839	GET	837:839	Herein, it is demonstrated that GET peptide coatings can mediate sustained intracellular transduction of magnetic NPs (MNPs), even in the presence of serum or plasma.
32924327	7	46	theme	stable	1272:1277	arg1	composition					1249:1259	their composition	1243:1259	their composition relatively stable but evolving	1243:1290	Using label-free snapshot proteomics, time-resolved profiles of human plasma coronas formed on functionalized GET-MNPs demonstrate that coronae quickly form (<1 min), with their composition relatively stable but evolving.
32924327	5	47	theme	NPs	919:921	arg1	transduction					894:905	sustained intracellular transduction	870:905	sustained intracellular transduction of magnetic NPs (MNPs)	870:928	Herein, it is demonstrated that GET peptide coatings can mediate sustained intracellular transduction of magnetic NPs (MNPs), even in the presence of serum or plasma.
32924327	4	48	theme	endocytotic	771:781	arg1	internalization					788:802	endocytotic cell internalization	771:802	endocytotic cell internalization	771:802	Glycosaminoglycan (GAG)-binding enhanced transduction (GET) is developed to efficiently deliver a variety of cargoes intracellularly; employing GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs) which enhance endocytotic cell internalization.
32924327	8	49	theme	GAG-binding	1391:1401	arg1	activities					1403:1412	GAG-binding activities	1391:1412	GAG-binding activities	1391:1412	Importantly GET-MNPs present a subtly different corona composition to MNPs alone, consistent with GAG-binding activities.
32924327	9	50	theme	novel	1537:1541	arg1	approaches					1557:1566	novel drug delivery approaches	1537:1566	novel drug delivery approaches for cell-type specific targeting of new nanomaterials	1537:1620	Understanding how NPs interact with biological systems and can retain enhanced intracellular transduction will facilitate novel drug delivery approaches for cell-type specific targeting of new nanomaterials.
32924327	6	51	theme	physicochemical	996:1010	arg1	properties					1012:1021	physicochemical properties	996:1021	physicochemical properties	996:1021	NP colloidal stability, physicochemical properties, toxicity and cellular uptake are investigated.
32924327	5	52	theme	magnetic	910:917	arg1	NPs					919:921	magnetic NPs	910:921	magnetic NPs (MNPs)	910:928	Herein, it is demonstrated that GET peptide coatings can mediate sustained intracellular transduction of magnetic NPs (MNPs), even in the presence of serum or plasma.
32924327	5	52	theme	magnetic	910:917	arg1	MNPs					924:927	MNPs	924:927	MNPs	924:927	Herein, it is demonstrated that GET peptide coatings can mediate sustained intracellular transduction of magnetic NPs (MNPs), even in the presence of serum or plasma.
32924327	9	53	theme	specific	1582:1589	arg1	targeting					1591:1599	cell-type specific targeting	1572:1599	cell-type specific targeting of new nanomaterials	1572:1620	Understanding how NPs interact with biological systems and can retain enhanced intracellular transduction will facilitate novel drug delivery approaches for cell-type specific targeting of new nanomaterials.
32924327	4	54	theme	GAG-binding	668:678	arg1	peptides					680:687	GAG-binding peptides	668:687	GAG-binding peptides	668:687	Glycosaminoglycan (GAG)-binding enhanced transduction (GET) is developed to efficiently deliver a variety of cargoes intracellularly; employing GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs) which enhance endocytotic cell internalization.
32924327	8	55	theme	different	1331:1339	arg1	composition					1348:1358	a subtly different corona composition	1322:1358	a subtly different corona composition	1322:1358	Importantly GET-MNPs present a subtly different corona composition to MNPs alone, consistent with GAG-binding activities.
32924327	0	56	theme	Plasma	77:82	arg1	Coronas					92:98	Rapidly Forming Plasma Protein Coronas	61:98	Rapidly Forming Plasma Protein Coronas	61:98	Enhanced Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas.
32924327	9	57	theme	delivery	1548:1555	arg1	approaches					1557:1566	novel drug delivery approaches	1537:1566	novel drug delivery approaches for cell-type specific targeting of new nanomaterials	1537:1620	Understanding how NPs interact with biological systems and can retain enhanced intracellular transduction will facilitate novel drug delivery approaches for cell-type specific targeting of new nanomaterials.
32924327	3	58	theme	specific	498:505	arg1	uptake					516:521	general or specific cellular uptake	487:521	general or specific cellular uptake	487:521	Coronae can critically influence self-interaction and binding of other molecules, which can affect toxicity, promote cell activation, and inhibit general or specific cellular uptake.
32924327	4	59	theme	cargoes	633:639	arg1	variety					622:628	a variety	620:628	a variety of cargoes	620:639	Glycosaminoglycan (GAG)-binding enhanced transduction (GET) is developed to efficiently deliver a variety of cargoes intracellularly; employing GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs) which enhance endocytotic cell internalization.
32924327	4	59	theme	cargoes	633:639	arg1	cargoes					633:639	cargoes	633:639	cargoes	633:639	Glycosaminoglycan (GAG)-binding enhanced transduction (GET) is developed to efficiently deliver a variety of cargoes intracellularly; employing GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs) which enhance endocytotic cell internalization.
32924327	0	60	theme	Forming	69:75	arg1	Coronas					92:98	Rapidly Forming Plasma Protein Coronas	61:98	Rapidly Forming Plasma Protein Coronas	61:98	Enhanced Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas.
32924327	4	61	theme	cell	783:786	arg1	internalization					788:802	endocytotic cell internalization	771:802	endocytotic cell internalization	771:802	Glycosaminoglycan (GAG)-binding enhanced transduction (GET) is developed to efficiently deliver a variety of cargoes intracellularly; employing GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs) which enhance endocytotic cell internalization.
32924327	3	62	theme	cellular	507:514	arg1	uptake					516:521	general or specific cellular uptake	487:521	general or specific cellular uptake	487:521	Coronae can critically influence self-interaction and binding of other molecules, which can affect toxicity, promote cell activation, and inhibit general or specific cellular uptake.
32924327	6	63	theme	colloidal	975:983	arg1	stability					985:993	NP colloidal stability	972:993	NP colloidal stability	972:993	NP colloidal stability, physicochemical properties, toxicity and cellular uptake are investigated.
32230916	3	0	theme	CS-based	526:533	arg1	solutions					535:543	CS-based solutions	526:543	CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix	526:632	Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix.
32230916	0	1	theme	Hierarchical	107:118	arg1	Scaffolds					120:128	Novel Hierarchical Scaffolds	101:128	Novel Hierarchical Scaffolds	101:128	Polylactide/Hydroxyapatite Nonwovens Incorporated into Chitosan/Graphene Materials Hydrogels to Form Novel Hierarchical Scaffolds.
32230916	3	2	with	solutions	535:543	arg1	oxide					559:563	graphene oxide	550:563	graphene oxide (GO)	550:568	Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix.
32230916	3	2	with	solutions	535:543	arg1	rGO					597:599	rGO	597:599	rGO	597:599	Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix.
32230916	3	2	with	solutions	535:543	arg1	oxide					590:594	reduced graphene oxide	573:594	reduced graphene oxide (rGO)	573:600	Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix.
32230916	1	3	theme	polylactide	191:201	arg1	microfibers					209:219	polylactide (PLA) microfibers	191:219	polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel	191:260	In this study, hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel were prepared for potential use in bone tissue engineering.
32230916	5	4	theme	mechanical	1014:1023	arg1	testing					1025:1031	rheological and mechanical testing	998:1031	rheological and mechanical testing	998:1031	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	4	theme	mechanical	1014:1023	arg1	nanofillers					804:814	the nanofillers	800:814	the nanofillers	800:814	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	1	5	theme	potential	280:288	arg1	use					290:292	potential use	280:292	potential use in bone tissue engineering	280:319	In this study, hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel were prepared for potential use in bone tissue engineering.
32230916	5	6	theme	attenuated	929:938	arg1	Fourier					957:963	attenuated total reflection Fourier	929:963	attenuated total reflection Fourier transform infrared spectroscopy	929:995	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	6	theme	attenuated	929:938	arg1	nanofillers					804:814	the nanofillers	800:814	the nanofillers	800:814	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	7	theme	reflection	946:955	arg1	Fourier					957:963	attenuated total reflection Fourier	929:963	attenuated total reflection Fourier transform infrared spectroscopy	929:995	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	7	theme	reflection	946:955	arg1	nanofillers					804:814	the nanofillers	800:814	the nanofillers	800:814	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	8	theme	photoelectron	879:891	arg1	spectroscopy					893:904	X-ray photoelectron spectroscopy	873:904	X-ray photoelectron spectroscopy	873:904	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	8	theme	photoelectron	879:891	arg1	nanofillers					804:814	the nanofillers	800:814	the nanofillers	800:814	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	9	theme	total	940:944	arg1	Fourier					957:963	attenuated total reflection Fourier	929:963	attenuated total reflection Fourier transform infrared spectroscopy	929:995	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	9	theme	total	940:944	arg1	nanofillers					804:814	the nanofillers	800:814	the nanofillers	800:814	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	10	dep	Fourier	957:963	arg1	transform					965:973	transform	965:973	transform infrared spectroscopy	965:995	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	1	11	dep	hierarchical	146:157	arg1	cylindrical					160:170	cylindrical	160:170	cylindrical	160:170	In this study, hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel were prepared for potential use in bone tissue engineering.
32230916	1	12	theme	PLA	204:206	arg1	microfibers					209:219	polylactide (PLA) microfibers	191:219	polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel	191:260	In this study, hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel were prepared for potential use in bone tissue engineering.
32230916	5	13	theme	composite	824:832	arg1	systems					834:840	the composite systems	820:840	the composite systems	820:840	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	3	14	theme	graphene	581:588	arg1	rGO					597:599	rGO	597:599	rGO	597:599	Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix.
32230916	3	14	theme	graphene	581:588	arg1	oxide					590:594	reduced graphene oxide	573:594	reduced graphene oxide (rGO)	573:600	Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix.
32230916	4	15	theme	freezing-thawing-gelling	677:700	arg1	method					702:707	a novel freezing-thawing-gelling method	669:707	a novel freezing-thawing-gelling method	669:707	Hydrogels were cross-linked using a novel freezing-thawing-gelling method.
32230916	5	16	dep	nanofillers	804:814	arg1	Fourier					957:963	attenuated total reflection Fourier	929:963	attenuated total reflection Fourier transform infrared spectroscopy	929:995	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	16	dep	nanofillers	804:814	arg1	bioactivity					1083:1093	bioactivity	1083:1093	bioactivity	1083:1093	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	16	dep	nanofillers	804:814	arg1	assessment					1049:1058	the assessment	1045:1058	the assessment of chemical stability	1045:1080	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	16	dep	nanofillers	804:814	arg1	microscopy					861:870	scanning electron microscopy	843:870	scanning electron microscopy	843:870	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	16	dep	nanofillers	804:814	arg1	cytocompatibility					1099:1115	cytocompatibility	1099:1115	cytocompatibility	1099:1115	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	16	dep	nanofillers	804:814	arg1	testing					1025:1031	rheological and mechanical testing	998:1031	rheological and mechanical testing	998:1031	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	16	dep	nanofillers	804:814	arg1	diffractometry					913:926	X-ray diffractometry	907:926	X-ray diffractometry	907:926	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	16	dep	nanofillers	804:814	arg1	spectroscopy					893:904	X-ray photoelectron spectroscopy	873:904	X-ray photoelectron spectroscopy	873:904	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	16	dep	nanofillers	804:814	arg1	nanofillers					804:814	the nanofillers	800:814	the nanofillers	800:814	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	4	17	theme	novel	671:675	arg1	method					702:707	a novel freezing-thawing-gelling method	669:707	a novel freezing-thawing-gelling method	669:707	Hydrogels were cross-linked using a novel freezing-thawing-gelling method.
32230916	1	18	theme	bone	297:300	arg1	engineering					309:319	bone tissue engineering	297:319	bone tissue engineering	297:319	In this study, hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel were prepared for potential use in bone tissue engineering.
32230916	2	19	theme	PLA	322:324	arg1	nonwovens					326:334	PLA nonwovens	322:334	PLA nonwovens modified with hydroxyapatite particles (HAp)	322:379	PLA nonwovens modified with hydroxyapatite particles (HAp) were obtained using the electrospinning method.
32230916	5	20	theme	electron	852:859	arg1	microscopy					861:870	scanning electron microscopy	843:870	scanning electron microscopy	843:870	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	20	theme	electron	852:859	arg1	nanofillers					804:814	the nanofillers	800:814	the nanofillers	800:814	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	21	theme	scanning	843:850	arg1	microscopy					861:870	scanning electron microscopy	843:870	scanning electron microscopy	843:870	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	21	theme	scanning	843:850	arg1	nanofillers					804:814	the nanofillers	800:814	the nanofillers	800:814	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	1	22	theme	tissue	302:307	arg1	engineering					309:319	bone tissue engineering	297:319	bone tissue engineering	297:319	In this study, hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel were prepared for potential use in bone tissue engineering.
32230916	1	23	from	use	290:292	arg1	engineering					309:319	bone tissue engineering	297:319	bone tissue engineering	297:319	In this study, hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel were prepared for potential use in bone tissue engineering.
32230916	3	24	theme	reduced	573:579	arg1	rGO					597:599	rGO	597:599	rGO	597:599	Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix.
32230916	3	24	theme	reduced	573:579	arg1	oxide					590:594	reduced graphene oxide	573:594	reduced graphene oxide (rGO)	573:600	Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix.
32230916	5	25	theme	research	730:737	arg1	methods					739:745	research methods	730:745	research methods	730:745	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	26	theme	X-ray	907:911	arg1	diffractometry					913:926	X-ray diffractometry	907:926	X-ray diffractometry	907:926	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	26	theme	X-ray	907:911	arg1	nanofillers					804:814	the nanofillers	800:814	the nanofillers	800:814	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	1	27	theme	chitosan	239:246	arg1	hydrogel					253:260	chitosan (CS) hydrogel	239:260	chitosan (CS) hydrogel	239:260	In this study, hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel were prepared for potential use in bone tissue engineering.
32230916	0	28	theme	Chitosan/Graphene	55:71	arg1	Materials					73:81	Chitosan/Graphene Materials	55:81	Chitosan/Graphene Materials	55:81	Polylactide/Hydroxyapatite Nonwovens Incorporated into Chitosan/Graphene Materials Hydrogels to Form Novel Hierarchical Scaffolds.
32230916	3	29	theme	three-dimensional	435:451	arg1	scaffolds					453:461	three-dimensional scaffolds	435:461	three-dimensional scaffolds	435:461	Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix.
32230916	5	30	theme	chemical	1063:1070	arg1	stability					1072:1080	chemical stability	1063:1080	chemical stability	1063:1080	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	31	theme	X-ray	873:877	arg1	spectroscopy					893:904	X-ray photoelectron spectroscopy	873:904	X-ray photoelectron spectroscopy	873:904	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	31	theme	X-ray	873:877	arg1	nanofillers					804:814	the nanofillers	800:814	the nanofillers	800:814	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	32	theme	stability	1072:1080	arg1	Fourier					957:963	attenuated total reflection Fourier	929:963	attenuated total reflection Fourier transform infrared spectroscopy	929:995	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	32	theme	stability	1072:1080	arg1	bioactivity					1083:1093	bioactivity	1083:1093	bioactivity	1083:1093	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	32	theme	stability	1072:1080	arg1	assessment					1049:1058	the assessment	1045:1058	the assessment of chemical stability	1045:1080	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	32	theme	stability	1072:1080	arg1	microscopy					861:870	scanning electron microscopy	843:870	scanning electron microscopy	843:870	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	32	theme	stability	1072:1080	arg1	cytocompatibility					1099:1115	cytocompatibility	1099:1115	cytocompatibility	1099:1115	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	32	theme	stability	1072:1080	arg1	testing					1025:1031	rheological and mechanical testing	998:1031	rheological and mechanical testing	998:1031	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	32	theme	stability	1072:1080	arg1	diffractometry					913:926	X-ray diffractometry	907:926	X-ray diffractometry	907:926	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	32	theme	stability	1072:1080	arg1	spectroscopy					893:904	X-ray photoelectron spectroscopy	873:904	X-ray photoelectron spectroscopy	873:904	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	32	theme	stability	1072:1080	arg1	nanofillers					804:814	the nanofillers	800:814	the nanofillers	800:814	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	3	33	dep	oxide	559:563	arg1	GO					566:567	GO	566:567	GO	566:567	Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix.
32230916	5	34	theme	methods	739:745	arg1	spectrum					718:725	A broad spectrum	710:725	A broad spectrum of research methods	710:745	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	1	35	theme	hierarchical	146:157	arg1	scaffolds					172:180	hierarchical, cylindrical scaffolds	146:180	hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel	146:260	In this study, hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel were prepared for potential use in bone tissue engineering.
32230916	3	36	theme	polymer	619:625	arg1	matrix					627:632	the polymer matrix	615:632	the polymer matrix	615:632	Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix.
32230916	2	37	theme	hydroxyapatite	350:363	arg1	particles					365:373	hydroxyapatite particles	350:373	hydroxyapatite particles (HAp)	350:379	PLA nonwovens modified with hydroxyapatite particles (HAp) were obtained using the electrospinning method.
32230916	2	37	theme	hydroxyapatite	350:363	arg1	HAp					376:378	HAp	376:378	HAp	376:378	PLA nonwovens modified with hydroxyapatite particles (HAp) were obtained using the electrospinning method.
32230916	5	38	theme	rheological	998:1008	arg1	testing					1025:1031	rheological and mechanical testing	998:1031	rheological and mechanical testing	998:1031	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	38	theme	rheological	998:1008	arg1	nanofillers					804:814	the nanofillers	800:814	the nanofillers	800:814	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	39	theme	broad	712:716	arg1	spectrum					718:725	A broad spectrum	710:725	A broad spectrum of research methods	710:745	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	5	40	theme	infrared	975:982	arg1	spectroscopy					984:995	infrared spectroscopy	975:995	infrared spectroscopy	975:995	A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.
32230916	0	41	theme	Novel	101:105	arg1	Scaffolds					120:128	Novel Hierarchical Scaffolds	101:128	Novel Hierarchical Scaffolds	101:128	Polylactide/Hydroxyapatite Nonwovens Incorporated into Chitosan/Graphene Materials Hydrogels to Form Novel Hierarchical Scaffolds.
32230916	2	42	theme	electrospinning	405:419	arg1	method					421:426	the electrospinning method	401:426	the electrospinning method	401:426	PLA nonwovens modified with hydroxyapatite particles (HAp) were obtained using the electrospinning method.
32230916	3	43	theme	graphene	550:557	arg1	oxide					559:563	graphene oxide	550:563	graphene oxide (GO)	550:568	Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix.
33806795	3	0	theme	Negative	322:329	arg1	charges					331:337	Negative charges	322:337	Negative charges at its core oligosaccharide (core-OS)	322:375	Negative charges at its core oligosaccharide (core-OS) contribute to membrane integrity through bridging interactions with divalent cations.
33806795	8	1	theme	syringae	1185:1192	arg1	complex					1202:1208	the P. syringae species complex	1178:1208	the P. syringae species complex	1178:1208	Our results suggest a genetic and structural conservation of the inner core-OS but variation in outer core-OS composition within the P. syringae species complex.
33806795	7	2	theme	other	1005:1009	arg1	strains					1040:1046	other plant-associated Pseudomonas strains	1005:1046	other plant-associated Pseudomonas strains	1005:1046	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	7	3	theme	model	913:917	arg1	DC3000					891:896	tomato (Pst) DC3000	878:896	tomato (Pst) DC3000	878:896	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	7	3	theme	model	913:917	arg1	pathogen					919:926	a widely used model pathogen	899:926	a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains	899:1046	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	2	4	from	interactions	294:305	arg1	particular					310:319	particular	310:319	particular	310:319	Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular.
33806795	2	4	from	interactions	294:305	arg1	general					268:274	general	268:274	general	268:274	Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular.
33806795	10	5	with	results	1365:1371	arg1	information					1420:1430	available structure information	1400:1430	available structure information	1400:1430	Finally, we combined the results of our genomic survey with available structure information to estimate the core-OS composition of other Pseudomonas species.
33806795	0	6	theme	Oligosaccharide	74:88	arg1	Biosynthesis					30:41	Biosynthesis	30:41	Biosynthesis	30:41	Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv.
33806795	0	6	theme	Oligosaccharide	74:88	arg1	Structure					16:24	Structure	16:24	Structure	16:24	Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv.
33806795	10	7	theme	structure	1410:1418	arg1	information					1420:1430	available structure information	1400:1430	available structure information	1400:1430	Finally, we combined the results of our genomic survey with available structure information to estimate the core-OS composition of other Pseudomonas species.
33806795	8	8	theme	genetic	1071:1077	arg1	conservation					1094:1105	a genetic and structural conservation	1069:1105	a genetic and structural conservation of the inner core-OS	1069:1126	Our results suggest a genetic and structural conservation of the inner core-OS but variation in outer core-OS composition within the P. syringae species complex.
33806795	4	9	dep	structure	477:485	arg1	The					463:465	The	463:465	The	463:465	The molecular structure and synthesis of the core-OS have been resolved in various bacteria including the mammalian pathogen Pseudomonas aeruginosa.
33806795	7	10	theme	P.	970:971	arg1	complex					990:996	the P. syringae species complex	966:996	the P. syringae species complex	966:996	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	10	11	theme	species	1489:1495	arg1	composition					1456:1466	the core-OS composition	1444:1466	the core-OS composition of other Pseudomonas species	1444:1495	Finally, we combined the results of our genomic survey with available structure information to estimate the core-OS composition of other Pseudomonas species.
33806795	6	12	theme	Pseudomonas	853:863	arg1	pv					874:875	Pseudomonas syringae pv	853:875	Pseudomonas syringae pv	853:875	We conducted a comparative genome analysis of the core-OS gene cluster in Pseudomonas syringae pv.
33806795	2	13	theme	host-pathogen	280:292	arg1	interactions					294:305	host-pathogen interactions	280:305	host-pathogen interactions in particular	280:319	Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular.
33806795	9	14	theme	Structural	1211:1220	arg1	analysis					1222:1229	Structural analysis	1211:1229	Structural analysis of the core-OS of Pst DC3000	1211:1258	Structural analysis of the core-OS of Pst DC3000 shows an uncommonly high phosphorylation and presence of an O-acetylated sugar.
33806795	0	15	theme	Pseudomonas	93:103	arg1	pv					114:115	Pseudomonas syringae pv	93:115	Pseudomonas syringae pv	93:115	Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv.
33806795	6	16	theme	genome	806:811	arg1	analysis					813:820	a comparative genome analysis	792:820	a comparative genome analysis of the core-OS gene cluster	792:848	We conducted a comparative genome analysis of the core-OS gene cluster in Pseudomonas syringae pv.
33806795	5	17	theme	plant-associated	640:655	arg1	strains					669:675	plant-associated Pseudomonas strains	640:675	plant-associated Pseudomonas strains	640:675	A few core-OS structures of plant-associated Pseudomonas strains have been solved to date, but the genetic components of the underlying biosynthesis remained unclear.
33806795	10	18	theme	other	1471:1475	arg1	species					1489:1495	other Pseudomonas species	1471:1495	other Pseudomonas species	1471:1495	Finally, we combined the results of our genomic survey with available structure information to estimate the core-OS composition of other Pseudomonas species.
33806795	3	19	theme	core	346:349	arg1	oligosaccharide					351:365	its core oligosaccharide	342:365	its core oligosaccharide (core-OS)	342:375	Negative charges at its core oligosaccharide (core-OS) contribute to membrane integrity through bridging interactions with divalent cations.
33806795	3	19	theme	core	346:349	arg1	core-OS					368:374	core-OS	368:374	core-OS	368:374	Negative charges at its core oligosaccharide (core-OS) contribute to membrane integrity through bridging interactions with divalent cations.
33806795	5	20	theme	strains	669:675	arg1	structures					626:635	A few core-OS structures	612:635	A few core-OS structures of plant-associated Pseudomonas strains	612:675	A few core-OS structures of plant-associated Pseudomonas strains have been solved to date, but the genetic components of the underlying biosynthesis remained unclear.
33806795	5	21	theme	Pseudomonas	657:667	arg1	strains					669:675	plant-associated Pseudomonas strains	640:675	plant-associated Pseudomonas strains	640:675	A few core-OS structures of plant-associated Pseudomonas strains have been solved to date, but the genetic components of the underlying biosynthesis remained unclear.
33806795	0	22	theme	pv	114:115	arg1	Oligosaccharide					74:88	the Lipopolysaccharide Core Oligosaccharide	46:88	the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv	46:115	Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv.
33806795	4	23	theme	core-OS	508:514	arg1	synthesis					491:499	synthesis	491:499	synthesis	491:499	The molecular structure and synthesis of the core-OS have been resolved in various bacteria including the mammalian pathogen Pseudomonas aeruginosa.
33806795	4	23	theme	core-OS	508:514	arg1	structure					477:485	molecular structure	467:485	molecular structure	467:485	The molecular structure and synthesis of the core-OS have been resolved in various bacteria including the mammalian pathogen Pseudomonas aeruginosa.
33806795	0	24	theme	Biosynthesis	30:41	arg1	Analysis					0:7	Analysis	0:7	Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv.	0:116	Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv.
33806795	6	25	theme	gene	837:840	arg1	cluster					842:848	the core-OS gene cluster	825:848	the core-OS gene cluster	825:848	We conducted a comparative genome analysis of the core-OS gene cluster in Pseudomonas syringae pv.
33806795	0	26	dep	Pseudomonas	93:103	arg1	syringae					105:112	syringae	105:112	syringae	105:112	Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv.
33806795	7	27	theme	Pst	886:888	arg1	DC3000					891:896	tomato (Pst) DC3000	878:896	tomato (Pst) DC3000	878:896	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	7	27	theme	Pst	886:888	arg1	pathogen					919:926	a widely used model pathogen	899:926	a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains	899:1046	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	9	28	theme	sugar	1333:1337	arg1	presence					1305:1312	presence	1305:1312	presence	1305:1312	Structural analysis of the core-OS of Pst DC3000 shows an uncommonly high phosphorylation and presence of an O-acetylated sugar.
33806795	9	28	theme	sugar	1333:1337	arg1	phosphorylation					1285:1299	uncommonly high phosphorylation	1269:1299	uncommonly high phosphorylation	1269:1299	Structural analysis of the core-OS of Pst DC3000 shows an uncommonly high phosphorylation and presence of an O-acetylated sugar.
33806795	7	29	theme	syringae	973:980	arg1	complex					990:996	the P. syringae species complex	966:996	the P. syringae species complex	966:996	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	8	30	theme	P.	1182:1183	arg1	complex					1202:1208	the P. syringae species complex	1178:1208	the P. syringae species complex	1178:1208	Our results suggest a genetic and structural conservation of the inner core-OS but variation in outer core-OS composition within the P. syringae species complex.
33806795	6	31	theme	core-OS	829:835	arg1	cluster					842:848	the core-OS gene cluster	825:848	the core-OS gene cluster	825:848	We conducted a comparative genome analysis of the core-OS gene cluster in Pseudomonas syringae pv.
33806795	7	32	from	pathogen	919:926	arg1	interactions					945:956	plant-microbe interactions	931:956	plant-microbe interactions	931:956	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	3	33	theme	membrane	391:398	arg1	integrity					400:408	membrane integrity	391:408	membrane integrity	391:408	Negative charges at its core oligosaccharide (core-OS) contribute to membrane integrity through bridging interactions with divalent cations.
33806795	5	34	theme	few	614:616	arg1	structures					626:635	A few core-OS structures	612:635	A few core-OS structures of plant-associated Pseudomonas strains	612:675	A few core-OS structures of plant-associated Pseudomonas strains have been solved to date, but the genetic components of the underlying biosynthesis remained unclear.
33806795	7	35	theme	species	982:988	arg1	complex					990:996	the P. syringae species complex	966:996	the P. syringae species complex	966:996	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	7	36	theme	tomato	878:883	arg1	DC3000					891:896	tomato (Pst) DC3000	878:896	tomato (Pst) DC3000	878:896	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	7	36	theme	tomato	878:883	arg1	pathogen					919:926	a widely used model pathogen	899:926	a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains	899:1046	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	3	37	theme	divalent	445:452	arg1	cations					454:460	divalent cations	445:460	divalent cations	445:460	Negative charges at its core oligosaccharide (core-OS) contribute to membrane integrity through bridging interactions with divalent cations.
33806795	0	38	theme	Structure	16:24	arg1	Analysis					0:7	Analysis	0:7	Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv.	0:116	Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv.
33806795	4	39	theme	mammalian	569:577	arg1	pathogen					579:586	the mammalian pathogen	565:586	the mammalian pathogen Pseudomonas aeruginosa	565:609	The molecular structure and synthesis of the core-OS have been resolved in various bacteria including the mammalian pathogen Pseudomonas aeruginosa.
33806795	8	40	theme	core-OS	1120:1126	arg1	conservation					1094:1105	a genetic and structural conservation	1069:1105	a genetic and structural conservation of the inner core-OS	1069:1126	Our results suggest a genetic and structural conservation of the inner core-OS but variation in outer core-OS composition within the P. syringae species complex.
33806795	5	41	theme	core-OS	618:624	arg1	structures					626:635	A few core-OS structures	612:635	A few core-OS structures of plant-associated Pseudomonas strains	612:675	A few core-OS structures of plant-associated Pseudomonas strains have been solved to date, but the genetic components of the underlying biosynthesis remained unclear.
33806795	10	42	theme	survey	1388:1393	arg1	results					1365:1371	the results	1361:1371	the results of our genomic survey with available structure information	1361:1430	Finally, we combined the results of our genomic survey with available structure information to estimate the core-OS composition of other Pseudomonas species.
33806795	10	43	theme	available	1400:1408	arg1	information					1420:1430	available structure information	1400:1430	available structure information	1400:1430	Finally, we combined the results of our genomic survey with available structure information to estimate the core-OS composition of other Pseudomonas species.
33806795	5	44	theme	underlying	737:746	arg1	biosynthesis					748:759	the underlying biosynthesis	733:759	the underlying biosynthesis	733:759	A few core-OS structures of plant-associated Pseudomonas strains have been solved to date, but the genetic components of the underlying biosynthesis remained unclear.
33806795	4	45	theme	molecular	467:475	arg1	structure					477:485	molecular structure	467:485	molecular structure	467:485	The molecular structure and synthesis of the core-OS have been resolved in various bacteria including the mammalian pathogen Pseudomonas aeruginosa.
33806795	2	46	from	viability	255:263	arg1	particular					310:319	particular	310:319	particular	310:319	Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular.
33806795	2	46	from	viability	255:263	arg1	general					268:274	general	268:274	general	268:274	Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular.
33806795	3	47	theme	bridging	418:425	arg1	interactions					427:438	bridging interactions	418:438	bridging interactions with divalent cations	418:460	Negative charges at its core oligosaccharide (core-OS) contribute to membrane integrity through bridging interactions with divalent cations.
33806795	5	48	theme	biosynthesis	748:759	arg1	components					719:728	the genetic components	707:728	the genetic components of the underlying biosynthesis	707:759	A few core-OS structures of plant-associated Pseudomonas strains have been solved to date, but the genetic components of the underlying biosynthesis remained unclear.
33806795	3	49	from	oligosaccharide	351:365	arg1	charges					331:337	Negative charges	322:337	Negative charges at its core oligosaccharide (core-OS)	322:375	Negative charges at its core oligosaccharide (core-OS) contribute to membrane integrity through bridging interactions with divalent cations.
33806795	8	50	theme	inner	1114:1118	arg1	core-OS					1120:1126	the inner core-OS	1110:1126	the inner core-OS	1110:1126	Our results suggest a genetic and structural conservation of the inner core-OS but variation in outer core-OS composition within the P. syringae species complex.
33806795	6	51	dep	Pseudomonas	853:863	arg1	syringae					865:872	syringae	865:872	syringae	865:872	We conducted a comparative genome analysis of the core-OS gene cluster in Pseudomonas syringae pv.
33806795	9	52	theme	high	1280:1283	arg1	phosphorylation					1285:1299	uncommonly high phosphorylation	1269:1299	uncommonly high phosphorylation	1269:1299	Structural analysis of the core-OS of Pst DC3000 shows an uncommonly high phosphorylation and presence of an O-acetylated sugar.
33806795	2	53	theme	major	163:167	arg1	component					169:177	the major component	159:177	the major component of the outer membrane of Gram-negative bacteria	159:225	Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular.
33806795	2	53	theme	major	163:167	arg1	Lipopolysaccharide					133:150	Lipopolysaccharide	133:150	Lipopolysaccharide (LPS)	133:156	Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular.
33806795	10	54	theme	genomic	1380:1386	arg1	survey					1388:1393	our genomic survey	1376:1393	our genomic survey	1376:1393	Finally, we combined the results of our genomic survey with available structure information to estimate the core-OS composition of other Pseudomonas species.
33806795	9	55	theme	core-OS	1238:1244	arg1	analysis					1222:1229	Structural analysis	1211:1229	Structural analysis of the core-OS of Pst DC3000	1211:1258	Structural analysis of the core-OS of Pst DC3000 shows an uncommonly high phosphorylation and presence of an O-acetylated sugar.
33806795	10	56	theme	Pseudomonas	1477:1487	arg1	species					1489:1495	other Pseudomonas species	1471:1495	other Pseudomonas species	1471:1495	Finally, we combined the results of our genomic survey with available structure information to estimate the core-OS composition of other Pseudomonas species.
33806795	4	57	theme	various	538:544	arg1	pathogen					579:586	the mammalian pathogen	565:586	the mammalian pathogen Pseudomonas aeruginosa	565:609	The molecular structure and synthesis of the core-OS have been resolved in various bacteria including the mammalian pathogen Pseudomonas aeruginosa.
33806795	4	57	theme	various	538:544	arg1	bacteria					546:553	various bacteria	538:553	various bacteria including the mammalian pathogen Pseudomonas aeruginosa	538:609	The molecular structure and synthesis of the core-OS have been resolved in various bacteria including the mammalian pathogen Pseudomonas aeruginosa.
33806795	8	58	theme	outer	1145:1149	arg1	composition					1159:1169	outer core-OS composition	1145:1169	outer core-OS composition within the P. syringae species complex	1145:1208	Our results suggest a genetic and structural conservation of the inner core-OS but variation in outer core-OS composition within the P. syringae species complex.
33806795	2	59	theme	bacteria	218:225	arg1	membrane					192:199	the outer membrane	182:199	the outer membrane of Gram-negative bacteria	182:225	Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular.
33806795	4	60	dep	pathogen	579:586	arg1	aeruginosa					600:609	Pseudomonas aeruginosa	588:609	the mammalian pathogen Pseudomonas aeruginosa	565:609	The molecular structure and synthesis of the core-OS have been resolved in various bacteria including the mammalian pathogen Pseudomonas aeruginosa.
33806795	5	61	theme	genetic	711:717	arg1	components					719:728	the genetic components	707:728	the genetic components of the underlying biosynthesis	707:759	A few core-OS structures of plant-associated Pseudomonas strains have been solved to date, but the genetic components of the underlying biosynthesis remained unclear.
33806795	2	62	theme	Gram-negative	204:216	arg1	bacteria					218:225	Gram-negative bacteria	204:225	Gram-negative bacteria	204:225	Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular.
33806795	6	63	theme	comparative	794:804	arg1	analysis					813:820	a comparative genome analysis	792:820	a comparative genome analysis of the core-OS gene cluster	792:848	We conducted a comparative genome analysis of the core-OS gene cluster in Pseudomonas syringae pv.
33806795	8	64	theme	structural	1083:1092	arg1	conservation					1094:1105	a genetic and structural conservation	1069:1105	a genetic and structural conservation of the inner core-OS	1069:1126	Our results suggest a genetic and structural conservation of the inner core-OS but variation in outer core-OS composition within the P. syringae species complex.
33806795	7	65	theme	plant-microbe	931:943	arg1	interactions					945:956	plant-microbe interactions	931:956	plant-microbe interactions	931:956	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	10	66	theme	core-OS	1448:1454	arg1	composition					1456:1466	the core-OS composition	1444:1466	the core-OS composition of other Pseudomonas species	1444:1495	Finally, we combined the results of our genomic survey with available structure information to estimate the core-OS composition of other Pseudomonas species.
33806795	2	67	theme	membrane	192:199	arg1	component					169:177	the major component	159:177	the major component of the outer membrane of Gram-negative bacteria	159:225	Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular.
33806795	2	67	theme	membrane	192:199	arg1	Lipopolysaccharide					133:150	Lipopolysaccharide	133:150	Lipopolysaccharide (LPS)	133:156	Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular.
33806795	8	68	theme	core-OS	1151:1157	arg1	composition					1159:1169	outer core-OS composition	1145:1169	outer core-OS composition within the P. syringae species complex	1145:1208	Our results suggest a genetic and structural conservation of the inner core-OS but variation in outer core-OS composition within the P. syringae species complex.
33806795	8	69	from	variation	1132:1140	arg1	composition					1159:1169	outer core-OS composition	1145:1169	outer core-OS composition within the P. syringae species complex	1145:1208	Our results suggest a genetic and structural conservation of the inner core-OS but variation in outer core-OS composition within the P. syringae species complex.
33806795	3	70	with	interactions	427:438	arg1	cations					454:460	divalent cations	445:460	divalent cations	445:460	Negative charges at its core oligosaccharide (core-OS) contribute to membrane integrity through bridging interactions with divalent cations.
33806795	2	71	theme	outer	186:190	arg1	membrane					192:199	the outer membrane	182:199	the outer membrane of Gram-negative bacteria	182:225	Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular.
33806795	2	72	theme	bacterial	245:253	arg1	viability					255:263	bacterial viability	245:263	bacterial viability in general	245:274	Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular.
33806795	7	73	theme	plant-associated	1011:1026	arg1	strains					1040:1046	other plant-associated Pseudomonas strains	1005:1046	other plant-associated Pseudomonas strains	1005:1046	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	6	74	theme	cluster	842:848	arg1	analysis					813:820	a comparative genome analysis	792:820	a comparative genome analysis of the core-OS gene cluster	792:848	We conducted a comparative genome analysis of the core-OS gene cluster in Pseudomonas syringae pv.
33806795	9	75	dep	phosphorylation	1285:1299	arg1	an					1266:1267	an	1266:1267	an	1266:1267	Structural analysis of the core-OS of Pst DC3000 shows an uncommonly high phosphorylation and presence of an O-acetylated sugar.
33806795	0	76	theme	Core	69:72	arg1	Oligosaccharide					74:88	the Lipopolysaccharide Core Oligosaccharide	46:88	the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv	46:115	Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv.
33806795	7	77	theme	Pseudomonas	1028:1038	arg1	strains					1040:1046	other plant-associated Pseudomonas strains	1005:1046	other plant-associated Pseudomonas strains	1005:1046	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	9	78	theme	Pst	1249:1251	arg1	core-OS					1238:1244	the core-OS	1234:1244	the core-OS of Pst DC3000	1234:1258	Structural analysis of the core-OS of Pst DC3000 shows an uncommonly high phosphorylation and presence of an O-acetylated sugar.
33806795	0	79	theme	Lipopolysaccharide	50:67	arg1	Oligosaccharide					74:88	the Lipopolysaccharide Core Oligosaccharide	46:88	the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv	46:115	Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of Pseudomonas syringae pv.
33806795	9	80	theme	O-acetylated	1320:1331	arg1	sugar					1333:1337	an O-acetylated sugar	1317:1337	an O-acetylated sugar	1317:1337	Structural analysis of the core-OS of Pst DC3000 shows an uncommonly high phosphorylation and presence of an O-acetylated sugar.
33806795	7	81	theme	used	908:911	arg1	DC3000					891:896	tomato (Pst) DC3000	878:896	tomato (Pst) DC3000	878:896	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	7	81	theme	used	908:911	arg1	pathogen					919:926	a widely used model pathogen	899:926	a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains	899:1046	tomato (Pst) DC3000, a widely used model pathogen in plant-microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains.
33806795	8	82	theme	species	1194:1200	arg1	complex					1202:1208	the P. syringae species complex	1178:1208	the P. syringae species complex	1178:1208	Our results suggest a genetic and structural conservation of the inner core-OS but variation in outer core-OS composition within the P. syringae species complex.
33675831	0	0	theme	in	73:74	arg1	digestibility					82:94	the in vitro digestibility	69:94	the in vitro digestibility	69:94	Synergetic modification of waxy maize starch by dual-enzyme to lower the in vitro digestibility through modulating molecular structure and malto-oligosaccharide content.
33675831	1	1	theme	starch	349:354	arg1	digestibility					321:333	in vitro digestibility	312:333	in vitro digestibility of waxy maize starch	312:354	Cyclodextrinase (CDase) and cyclodextrin glucosyltransferase (CGTase) were synergistically used to provide a novel enzymatic method in lowing in vitro digestibility of waxy maize starch.
33675831	1	2	dep	in	312:313	arg1	vitro					315:319	vitro	315:319	vitro	315:319	Cyclodextrinase (CDase) and cyclodextrin glucosyltransferase (CGTase) were synergistically used to provide a novel enzymatic method in lowing in vitro digestibility of waxy maize starch.
33675831	3	3	theme	simultaneous	722:733	arg1	treatment					735:743	simultaneous treatment	722:743	simultaneous treatment	722:743	The molecular weight was reduced to 0.3 × 105 g/mol and 0.2 × 105 g/mol by simultaneous and sequential treatment with CDase and CGTase, while the highest proportion of chains with degree of polymerization (DP) < 13 was obtained by simultaneous treatment.
33675831	7	4	theme	enzymes	1205:1211	arg1	pattern					1184:1190	the hydrolysis pattern	1169:1190	the hydrolysis pattern of these two enzymes on the starch hydrolysate	1169:1237	The starch digestion kinetics further revealed the hydrolysis pattern of these two enzymes on the starch hydrolysate.
33675831	2	5	theme	molecular	361:369	arg1	structure					371:379	The molecular structure	357:379	The molecular structure	357:379	The molecular structure, malto-oligosaccharide composition, and digestibility properties of the generated products were investigated.
33675831	1	6	theme	novel	279:283	arg1	method					295:300	a novel enzymatic method	277:300	a novel enzymatic method	277:300	Cyclodextrinase (CDase) and cyclodextrin glucosyltransferase (CGTase) were synergistically used to provide a novel enzymatic method in lowing in vitro digestibility of waxy maize starch.
33675831	1	7	theme	enzymatic	285:293	arg1	method					295:300	a novel enzymatic method	277:300	a novel enzymatic method	277:300	Cyclodextrinase (CDase) and cyclodextrin glucosyltransferase (CGTase) were synergistically used to provide a novel enzymatic method in lowing in vitro digestibility of waxy maize starch.
33675831	7	8	theme	hydrolysis	1173:1182	arg1	pattern					1184:1190	the hydrolysis pattern	1169:1190	the hydrolysis pattern of these two enzymes on the starch hydrolysate	1169:1237	The starch digestion kinetics further revealed the hydrolysis pattern of these two enzymes on the starch hydrolysate.
33675831	3	9	theme	sequential	583:592	arg1	treatment					594:602	simultaneous and sequential treatment	566:602	simultaneous and sequential treatment with CDase and CGTase	566:624	The molecular weight was reduced to 0.3 × 105 g/mol and 0.2 × 105 g/mol by simultaneous and sequential treatment with CDase and CGTase, while the highest proportion of chains with degree of polymerization (DP) < 13 was obtained by simultaneous treatment.
33675831	8	10	theme	starch	1263:1268	arg1	digestibility					1270:1282	the starch digestibility	1259:1282	the starch digestibility	1259:1282	It was proved that the starch digestibility could be lowered by modulating the molecular structure and beneficial MOSs content by this dual-enzyme treatment.
33675831	2	11	theme	digestibility	421:433	arg1	properties					435:444	digestibility properties	421:444	digestibility properties	421:444	The molecular structure, malto-oligosaccharide composition, and digestibility properties of the generated products were investigated.
33675831	7	12	theme	starch	1220:1225	arg1	hydrolysate					1227:1237	the starch hydrolysate	1216:1237	the starch hydrolysate	1216:1237	The starch digestion kinetics further revealed the hydrolysis pattern of these two enzymes on the starch hydrolysate.
33675831	5	13	theme	malto-oligosaccharides	926:947	arg1	content					915:921	the content	911:921	the content of malto-oligosaccharides (MOSs)	911:954	Dual-enzyme treatment significantly promoted the content of malto-oligosaccharides (MOSs) by hydrolyzing cyclodextrins from CGTase with CDase.
33675831	7	14	from	pattern	1184:1190	arg1	hydrolysate					1227:1237	the starch hydrolysate	1216:1237	the starch hydrolysate	1216:1237	The starch digestion kinetics further revealed the hydrolysis pattern of these two enzymes on the starch hydrolysate.
33675831	0	15	dep	in	73:74	arg1	vitro					76:80	vitro	76:80	vitro	76:80	Synergetic modification of waxy maize starch by dual-enzyme to lower the in vitro digestibility through modulating molecular structure and malto-oligosaccharide content.
33675831	0	16	theme	Synergetic	0:9	arg1	modification					11:22	Synergetic modification	0:22	Synergetic modification of waxy maize starch by dual-enzyme	0:58	Synergetic modification of waxy maize starch by dual-enzyme to lower the in vitro digestibility through modulating molecular structure and malto-oligosaccharide content.
33675831	1	17	theme	cyclodextrin	198:209	arg1	CGTase					232:237	CGTase	232:237	CGTase	232:237	Cyclodextrinase (CDase) and cyclodextrin glucosyltransferase (CGTase) were synergistically used to provide a novel enzymatic method in lowing in vitro digestibility of waxy maize starch.
33675831	1	17	theme	cyclodextrin	198:209	arg1	glucosyltransferase					211:229	cyclodextrin glucosyltransferase	198:229	cyclodextrin glucosyltransferase (CGTase)	198:238	Cyclodextrinase (CDase) and cyclodextrin glucosyltransferase (CGTase) were synergistically used to provide a novel enzymatic method in lowing in vitro digestibility of waxy maize starch.
33675831	0	18	theme	waxy	27:30	arg1	starch					38:43	waxy maize starch	27:43	waxy maize starch	27:43	Synergetic modification of waxy maize starch by dual-enzyme to lower the in vitro digestibility through modulating molecular structure and malto-oligosaccharide content.
33675831	6	19	theme	cyclodextrins	1037:1049	arg1	replacement					1022:1032	the replacement	1018:1032	the replacement of cyclodextrins by MOSs	1018:1057	However, the replacement of cyclodextrins by MOSs did not obviously influence the digestibility of the products.
33675831	5	20	from	CGTase	990:995	arg1	cyclodextrins					971:983	cyclodextrins	971:983	cyclodextrins from CGTase	971:995	Dual-enzyme treatment significantly promoted the content of malto-oligosaccharides (MOSs) by hydrolyzing cyclodextrins from CGTase with CDase.
33675831	2	21	theme	generated	453:461	arg1	products					463:470	the generated products	449:470	the generated products	449:470	The molecular structure, malto-oligosaccharide composition, and digestibility properties of the generated products were investigated.
33675831	2	22	theme	products	463:470	arg1	structure					371:379	The molecular structure	357:379	The molecular structure	357:379	The molecular structure, malto-oligosaccharide composition, and digestibility properties of the generated products were investigated.
33675831	2	22	theme	products	463:470	arg1	composition					404:414	malto-oligosaccharide composition	382:414	malto-oligosaccharide composition	382:414	The molecular structure, malto-oligosaccharide composition, and digestibility properties of the generated products were investigated.
33675831	2	22	theme	products	463:470	arg1	properties					435:444	digestibility properties	421:444	digestibility properties	421:444	The molecular structure, malto-oligosaccharide composition, and digestibility properties of the generated products were investigated.
33675831	7	23	theme	starch	1126:1131	arg1	kinetics					1143:1150	The starch digestion kinetics	1122:1150	The starch digestion kinetics	1122:1150	The starch digestion kinetics further revealed the hydrolysis pattern of these two enzymes on the starch hydrolysate.
33675831	0	24	theme	molecular	115:123	arg1	structure					125:133	molecular structure	115:133	molecular structure	115:133	Synergetic modification of waxy maize starch by dual-enzyme to lower the in vitro digestibility through modulating molecular structure and malto-oligosaccharide content.
33675831	3	25	theme	simultaneous	566:577	arg1	treatment					594:602	simultaneous and sequential treatment	566:602	simultaneous and sequential treatment with CDase and CGTase	566:624	The molecular weight was reduced to 0.3 × 105 g/mol and 0.2 × 105 g/mol by simultaneous and sequential treatment with CDase and CGTase, while the highest proportion of chains with degree of polymerization (DP) < 13 was obtained by simultaneous treatment.
33675831	0	26	theme	starch	38:43	arg1	modification					11:22	Synergetic modification	0:22	Synergetic modification of waxy maize starch by dual-enzyme	0:58	Synergetic modification of waxy maize starch by dual-enzyme to lower the in vitro digestibility through modulating molecular structure and malto-oligosaccharide content.
33675831	1	27	theme	in	312:313	arg1	digestibility					321:333	in vitro digestibility	312:333	in vitro digestibility of waxy maize starch	312:354	Cyclodextrinase (CDase) and cyclodextrin glucosyltransferase (CGTase) were synergistically used to provide a novel enzymatic method in lowing in vitro digestibility of waxy maize starch.
33675831	0	28	theme	malto-oligosaccharide	139:159	arg1	content					161:167	malto-oligosaccharide content	139:167	malto-oligosaccharide content	139:167	Synergetic modification of waxy maize starch by dual-enzyme to lower the in vitro digestibility through modulating molecular structure and malto-oligosaccharide content.
33675831	8	29	theme	molecular	1319:1327	arg1	structure					1329:1337	the molecular structure	1315:1337	the molecular structure	1315:1337	It was proved that the starch digestibility could be lowered by modulating the molecular structure and beneficial MOSs content by this dual-enzyme treatment.
33675831	6	30	theme	products	1112:1119	arg1	digestibility					1091:1103	the digestibility	1087:1103	the digestibility of the products	1087:1119	However, the replacement of cyclodextrins by MOSs did not obviously influence the digestibility of the products.
33675831	0	31	theme	maize	32:36	arg1	starch					38:43	waxy maize starch	27:43	waxy maize starch	27:43	Synergetic modification of waxy maize starch by dual-enzyme to lower the in vitro digestibility through modulating molecular structure and malto-oligosaccharide content.
33675831	3	32	with	treatment	594:602	arg1	CGTase					619:624	CGTase	619:624	CGTase	619:624	The molecular weight was reduced to 0.3 × 105 g/mol and 0.2 × 105 g/mol by simultaneous and sequential treatment with CDase and CGTase, while the highest proportion of chains with degree of polymerization (DP) < 13 was obtained by simultaneous treatment.
33675831	3	32	with	treatment	594:602	arg1	CDase					609:613	CDase	609:613	CDase	609:613	The molecular weight was reduced to 0.3 × 105 g/mol and 0.2 × 105 g/mol by simultaneous and sequential treatment with CDase and CGTase, while the highest proportion of chains with degree of polymerization (DP) < 13 was obtained by simultaneous treatment.
33675831	3	33	theme	polymerization	681:694	arg1	 < 13					700:704	polymerization (DP) < 13	681:704	polymerization (DP) < 13	681:704	The molecular weight was reduced to 0.3 × 105 g/mol and 0.2 × 105 g/mol by simultaneous and sequential treatment with CDase and CGTase, while the highest proportion of chains with degree of polymerization (DP) < 13 was obtained by simultaneous treatment.
33675831	5	34	theme	Dual-enzyme	866:876	arg1	treatment					878:886	Dual-enzyme treatment	866:886	Dual-enzyme treatment	866:886	Dual-enzyme treatment significantly promoted the content of malto-oligosaccharides (MOSs) by hydrolyzing cyclodextrins from CGTase with CDase.
33675831	3	35	theme	molecular	495:503	arg1	weight					505:510	The molecular weight	491:510	The molecular weight	491:510	The molecular weight was reduced to 0.3 × 105 g/mol and 0.2 × 105 g/mol by simultaneous and sequential treatment with CDase and CGTase, while the highest proportion of chains with degree of polymerization (DP) < 13 was obtained by simultaneous treatment.
33675831	4	36	theme	starch	760:765	arg1	contents					767:774	The resistant starch contents	746:774	The resistant starch contents	746:774	The resistant starch contents were increased to 27.5% and 36.9% by simultaneous and sequential treatments respectively.
33675831	7	37	theme	digestion	1133:1141	arg1	kinetics					1143:1150	The starch digestion kinetics	1122:1150	The starch digestion kinetics	1122:1150	The starch digestion kinetics further revealed the hydrolysis pattern of these two enzymes on the starch hydrolysate.
33675831	3	38	theme	highest	637:643	arg1	proportion					645:654	the highest proportion	633:654	the highest proportion of chains with degree of polymerization (DP) < 13	633:704	The molecular weight was reduced to 0.3 × 105 g/mol and 0.2 × 105 g/mol by simultaneous and sequential treatment with CDase and CGTase, while the highest proportion of chains with degree of polymerization (DP) < 13 was obtained by simultaneous treatment.
33675831	4	39	theme	resistant	750:758	arg1	contents					767:774	The resistant starch contents	746:774	The resistant starch contents	746:774	The resistant starch contents were increased to 27.5% and 36.9% by simultaneous and sequential treatments respectively.
33675831	1	40	theme	waxy	338:341	arg1	starch					349:354	waxy maize starch	338:354	waxy maize starch	338:354	Cyclodextrinase (CDase) and cyclodextrin glucosyltransferase (CGTase) were synergistically used to provide a novel enzymatic method in lowing in vitro digestibility of waxy maize starch.
33675831	1	41	used	used	261:264	arg2	CDase					187:191	CDase	187:191	CDase	187:191	Cyclodextrinase (CDase) and cyclodextrin glucosyltransferase (CGTase) were synergistically used to provide a novel enzymatic method in lowing in vitro digestibility of waxy maize starch.
33675831	1	41	used	used	261:264	arg2	Cyclodextrinase					170:184	Cyclodextrinase	170:184	Cyclodextrinase (CDase)	170:192	Cyclodextrinase (CDase) and cyclodextrin glucosyltransferase (CGTase) were synergistically used to provide a novel enzymatic method in lowing in vitro digestibility of waxy maize starch.
33675831	1	41	used	used	261:264	arg2	glucosyltransferase					211:229	cyclodextrin glucosyltransferase	198:229	cyclodextrin glucosyltransferase (CGTase)	198:238	Cyclodextrinase (CDase) and cyclodextrin glucosyltransferase (CGTase) were synergistically used to provide a novel enzymatic method in lowing in vitro digestibility of waxy maize starch.
33675831	1	41	used	used	261:264	arg2	CGTase					232:237	CGTase	232:237	CGTase	232:237	Cyclodextrinase (CDase) and cyclodextrin glucosyltransferase (CGTase) were synergistically used to provide a novel enzymatic method in lowing in vitro digestibility of waxy maize starch.
33675831	3	42	theme	 < 13	700:704	arg1	degree					671:676	degree	671:676	degree of polymerization (DP) < 13	671:704	The molecular weight was reduced to 0.3 × 105 g/mol and 0.2 × 105 g/mol by simultaneous and sequential treatment with CDase and CGTase, while the highest proportion of chains with degree of polymerization (DP) < 13 was obtained by simultaneous treatment.
33675831	4	43	theme	simultaneous	813:824	arg1	treatments					841:850	simultaneous and sequential treatments	813:850	simultaneous and sequential treatments	813:850	The resistant starch contents were increased to 27.5% and 36.9% by simultaneous and sequential treatments respectively.
33675831	8	44	theme	dual-enzyme	1375:1385	arg1	treatment					1387:1395	this dual-enzyme treatment	1370:1395	this dual-enzyme treatment	1370:1395	It was proved that the starch digestibility could be lowered by modulating the molecular structure and beneficial MOSs content by this dual-enzyme treatment.
33675831	3	45	with	chains	659:664	arg1	degree					671:676	degree	671:676	degree of polymerization (DP) < 13	671:704	The molecular weight was reduced to 0.3 × 105 g/mol and 0.2 × 105 g/mol by simultaneous and sequential treatment with CDase and CGTase, while the highest proportion of chains with degree of polymerization (DP) < 13 was obtained by simultaneous treatment.
33675831	8	46	theme	MOSs	1354:1357	arg1	content					1359:1365	beneficial MOSs content	1343:1365	beneficial MOSs content	1343:1365	It was proved that the starch digestibility could be lowered by modulating the molecular structure and beneficial MOSs content by this dual-enzyme treatment.
33675831	3	47	theme	chains	659:664	arg1	proportion					645:654	the highest proportion	633:654	the highest proportion of chains with degree of polymerization (DP) < 13	633:704	The molecular weight was reduced to 0.3 × 105 g/mol and 0.2 × 105 g/mol by simultaneous and sequential treatment with CDase and CGTase, while the highest proportion of chains with degree of polymerization (DP) < 13 was obtained by simultaneous treatment.
33675831	8	48	theme	beneficial	1343:1352	arg1	content					1359:1365	beneficial MOSs content	1343:1365	beneficial MOSs content	1343:1365	It was proved that the starch digestibility could be lowered by modulating the molecular structure and beneficial MOSs content by this dual-enzyme treatment.
33675831	2	49	theme	malto-oligosaccharide	382:402	arg1	composition					404:414	malto-oligosaccharide composition	382:414	malto-oligosaccharide composition	382:414	The molecular structure, malto-oligosaccharide composition, and digestibility properties of the generated products were investigated.
33675831	1	50	theme	maize	343:347	arg1	starch					349:354	waxy maize starch	338:354	waxy maize starch	338:354	Cyclodextrinase (CDase) and cyclodextrin glucosyltransferase (CGTase) were synergistically used to provide a novel enzymatic method in lowing in vitro digestibility of waxy maize starch.
33675831	4	51	theme	sequential	830:839	arg1	treatments					841:850	simultaneous and sequential treatments	813:850	simultaneous and sequential treatments	813:850	The resistant starch contents were increased to 27.5% and 36.9% by simultaneous and sequential treatments respectively.
32535373	4	0	theme	density	699:705	arg1	1.27					714:717	1.27	714:717	1.27	714:717	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	4	0	theme	density	699:705	arg1	ratio					707:711	energy density ratio	692:711	energy density ratio (1.27)	692:718	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	2	1	theme	pellets	360:366	arg1	torrefaction					300:311	torrefaction	300:311	torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs)	300:372	In current study, torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs) was performed by employing tubular reactor furnace, and quality of pellets was compared.
32535373	8	2	theme	cellulose	1547:1555	arg1	crystallinity					1530:1542	the crystallinity	1526:1542	the crystallinity of cellulose in TFRPs	1526:1564	The crystallinity of cellulose in FRPs was found higher than that of SPs, while the crystallinity of cellulose in TFRPs was found lower than that of TSPs at same process conditions.
32535373	0	3	theme	residue	84:90	arg1	Characterization					42:57	Characterization	42:57	Characterization	42:57	Torrefaction subsequent to pelletization: Characterization and analysis of furfural residue and sawdust pellets.
32535373	0	3	theme	residue	84:90	arg1	analysis					63:70	analysis	63:70	analysis	63:70	Torrefaction subsequent to pelletization: Characterization and analysis of furfural residue and sawdust pellets.
32535373	6	4	dep	%	1207:1207	arg1	i.e.					1190:1193	i.e.	1190:1193	i.e.	1190:1193	The highest true densities (i.e. 2.40 and 1.85 g/cm3) and porosities (i.e. 52 and 65 v %) of TFRPs and TSPs were achieved at 300 °C and 120 min, much higher than those of un-torrefied pellets.
32535373	2	5	theme	sawdust	352:358	arg1	pellets					360:366	sawdust pellets	352:366	sawdust pellets (SPs)	352:372	In current study, torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs) was performed by employing tubular reactor furnace, and quality of pellets was compared.
32535373	2	5	theme	sawdust	352:358	arg1	SPs					369:371	SPs	369:371	SPs	369:371	In current study, torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs) was performed by employing tubular reactor furnace, and quality of pellets was compared.
32535373	4	6	theme	torrefied	724:732	arg1	TFRPs					760:764	TFRPs	760:764	TFRPs	760:764	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	4	6	theme	torrefied	724:732	arg1	pellets					751:757	torrefied furfural residue pellets	724:757	torrefied furfural residue pellets (TFRPs)	724:765	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	0	7	theme	pellets	104:110	arg1	Characterization					42:57	Characterization	42:57	Characterization	42:57	Torrefaction subsequent to pelletization: Characterization and analysis of furfural residue and sawdust pellets.
32535373	0	7	theme	pellets	104:110	arg1	analysis					63:70	analysis	63:70	analysis	63:70	Torrefaction subsequent to pelletization: Characterization and analysis of furfural residue and sawdust pellets.
32535373	6	8	theme	v	1205:1205	arg1	%					1207:1207	52 and 65 v %	1195:1207	52 and 65 v %	1195:1207	The highest true densities (i.e. 2.40 and 1.85 g/cm3) and porosities (i.e. 52 and 65 v %) of TFRPs and TSPs were achieved at 300 °C and 120 min, much higher than those of un-torrefied pellets.
32535373	7	9	theme	TFRPs	1332:1336	arg1	uptake					1322:1327	Moisture uptake	1313:1327	Moisture uptake of TFRPs and TSPs at 300 °C	1313:1355	Moisture uptake of TFRPs and TSPs at 300 °C were only 1.4 wt% and 2.0-2.8 wt%, respectively, showing strong water-resistant ability.
32535373	4	10	theme	furfural	734:741	arg1	TFRPs					760:764	TFRPs	760:764	TFRPs	760:764	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	4	10	theme	furfural	734:741	arg1	pellets					751:757	torrefied furfural residue pellets	724:757	torrefied furfural residue pellets (TFRPs)	724:765	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	0	11	theme	sawdust	96:102	arg1	pellets					104:110	sawdust pellets	96:110	sawdust pellets	96:110	Torrefaction subsequent to pelletization: Characterization and analysis of furfural residue and sawdust pellets.
32535373	5	12	dep	16.69 kJ/m3	1107:1117	arg1	to					1104:1105	to	1104:1105	to	1104:1105	Increasing torrefaction temperature and residence time, the volumetric energy densities of TFRPs increased from 25.69 (at 200 °C and 15 min) to 27.59 kJ/m3 (at 300 °C and 120 min), while those of TSPs correspondingly decreased from 20.81 to 16.69 kJ/m3.
32535373	6	13	theme	true	1132:1135	arg1	densities					1137:1145	The highest true densities	1120:1145	The highest true densities (i.e. 2.40 and 1.85 g/cm3)	1120:1172	The highest true densities (i.e. 2.40 and 1.85 g/cm3) and porosities (i.e. 52 and 65 v %) of TFRPs and TSPs were achieved at 300 °C and 120 min, much higher than those of un-torrefied pellets.
32535373	6	14	dep	densities	1137:1145	arg1	2.40					1153:1156	2.40	1153:1156	2.40	1153:1156	The highest true densities (i.e. 2.40 and 1.85 g/cm3) and porosities (i.e. 52 and 65 v %) of TFRPs and TSPs were achieved at 300 °C and 120 min, much higher than those of un-torrefied pellets.
32535373	6	14	dep	densities	1137:1145	arg1	1.85 g/cm3					1162:1171	1.85 g/cm3	1162:1171	1.85 g/cm3	1162:1171	The highest true densities (i.e. 2.40 and 1.85 g/cm3) and porosities (i.e. 52 and 65 v %) of TFRPs and TSPs were achieved at 300 °C and 120 min, much higher than those of un-torrefied pellets.
32535373	3	15	theme	types	491:495	arg1	characteristics					467:481	The characteristics	463:481	The characteristics of both types of pellets	463:506	The characteristics of both types of pellets were significantly improved with increasing torrefaction temperature from 200 °C to 300 °C and residence time from 15 min to 30 min.
32535373	5	16	from	300 °C	1026:1031	arg1	27.59 kJ/m3					1010:1020	27.59 kJ/m3	1010:1020	27.59 kJ/m3 (at 300 °C and 120 min)	1010:1044	Increasing torrefaction temperature and residence time, the volumetric energy densities of TFRPs increased from 25.69 (at 200 °C and 15 min) to 27.59 kJ/m3 (at 300 °C and 120 min), while those of TSPs correspondingly decreased from 20.81 to 16.69 kJ/m3.
32535373	2	17	theme	reactor	409:415	arg1	furnace					417:423	tubular reactor furnace	401:423	tubular reactor furnace	401:423	In current study, torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs) was performed by employing tubular reactor furnace, and quality of pellets was compared.
32535373	5	18	theme	TFRPs	957:961	arg1	densities					944:952	the volumetric energy densities	922:952	the volumetric energy densities of TFRPs	922:961	Increasing torrefaction temperature and residence time, the volumetric energy densities of TFRPs increased from 25.69 (at 200 °C and 15 min) to 27.59 kJ/m3 (at 300 °C and 120 min), while those of TSPs correspondingly decreased from 20.81 to 16.69 kJ/m3.
32535373	8	19	from	conditions	1616:1625	arg1	TSPs					1595:1598	TSPs	1595:1598	TSPs at same process conditions	1595:1625	The crystallinity of cellulose in FRPs was found higher than that of SPs, while the crystallinity of cellulose in TFRPs was found lower than that of TSPs at same process conditions.
32535373	4	20	theme	heating	659:665	arg1	value					667:671	The highest lower heating value	641:671	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs)	641:827	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	6	21	theme	un-torrefied	1291:1302	arg1	pellets					1304:1310	un-torrefied pellets	1291:1310	un-torrefied pellets	1291:1310	The highest true densities (i.e. 2.40 and 1.85 g/cm3) and porosities (i.e. 52 and 65 v %) of TFRPs and TSPs were achieved at 300 °C and 120 min, much higher than those of un-torrefied pellets.
32535373	5	22	theme	torrefaction	877:888	arg1	temperature					890:900	torrefaction temperature	877:900	torrefaction temperature	877:900	Increasing torrefaction temperature and residence time, the volumetric energy densities of TFRPs increased from 25.69 (at 200 °C and 15 min) to 27.59 kJ/m3 (at 300 °C and 120 min), while those of TSPs correspondingly decreased from 20.81 to 16.69 kJ/m3.
32535373	2	23	theme	current	285:291	arg1	study					293:297	current study	285:297	current study	285:297	In current study, torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs) was performed by employing tubular reactor furnace, and quality of pellets was compared.
32535373	4	24	theme	lower	653:657	arg1	heating					659:665	lower heating	653:665	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs)	641:827	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	0	25	theme	subsequent	13:22	arg1	Torrefaction					0:11	Torrefaction	0:11	Torrefaction subsequent to pelletization: Characterization and analysis of furfural residue and sawdust pellets.	0:111	Torrefaction subsequent to pelletization: Characterization and analysis of furfural residue and sawdust pellets.
32535373	6	26	theme	higher	1270:1275	arg1	300 °C					1245:1250	300 °C	1245:1250	300 °C	1245:1250	The highest true densities (i.e. 2.40 and 1.85 g/cm3) and porosities (i.e. 52 and 65 v %) of TFRPs and TSPs were achieved at 300 °C and 120 min, much higher than those of un-torrefied pellets.
32535373	2	27	theme	pellets	333:339	arg1	torrefaction					300:311	torrefaction	300:311	torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs)	300:372	In current study, torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs) was performed by employing tubular reactor furnace, and quality of pellets was compared.
32535373	8	28	from	crystallinity	1450:1462	arg1	FRPs					1480:1483	FRPs	1480:1483	FRPs	1480:1483	The crystallinity of cellulose in FRPs was found higher than that of SPs, while the crystallinity of cellulose in TFRPs was found lower than that of TSPs at same process conditions.
32535373	4	29	theme	highest	645:651	arg1	value					667:671	The highest lower heating value	641:671	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs)	641:827	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	2	30	theme	residue	325:331	arg1	FRPs					342:345	FRPs	342:345	FRPs	342:345	In current study, torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs) was performed by employing tubular reactor furnace, and quality of pellets was compared.
32535373	2	30	theme	residue	325:331	arg1	pellets					333:339	furfural residue pellets	316:339	furfural residue pellets (FRPs)	316:346	In current study, torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs) was performed by employing tubular reactor furnace, and quality of pellets was compared.
32535373	7	31	theme	water-resistant	1421:1435	arg1	ability					1437:1443	strong water-resistant ability	1414:1443	strong water-resistant ability	1414:1443	Moisture uptake of TFRPs and TSPs at 300 °C were only 1.4 wt% and 2.0-2.8 wt%, respectively, showing strong water-resistant ability.
32535373	7	32	from	300 °C	1350:1355	arg1	uptake					1322:1327	Moisture uptake	1313:1327	Moisture uptake of TFRPs and TSPs at 300 °C	1313:1355	Moisture uptake of TFRPs and TSPs at 300 °C were only 1.4 wt% and 2.0-2.8 wt%, respectively, showing strong water-resistant ability.
32535373	4	33	theme	sawdust	806:812	arg1	pellets					814:820	torrefied sawdust pellets	796:820	torrefied sawdust pellets	796:820	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	3	34	theme	torrefaction	552:563	arg1	temperature					565:575	torrefaction temperature	552:575	torrefaction temperature from 200 °C to 300 °C and residence time	552:616	The characteristics of both types of pellets were significantly improved with increasing torrefaction temperature from 200 °C to 300 °C and residence time from 15 min to 30 min.
32535373	5	35	theme	energy	937:942	arg1	densities					944:952	the volumetric energy densities	922:952	the volumetric energy densities of TFRPs	922:961	Increasing torrefaction temperature and residence time, the volumetric energy densities of TFRPs increased from 25.69 (at 200 °C and 15 min) to 27.59 kJ/m3 (at 300 °C and 120 min), while those of TSPs correspondingly decreased from 20.81 to 16.69 kJ/m3.
32535373	7	36	theme	Moisture	1313:1320	arg1	uptake					1322:1327	Moisture uptake	1313:1327	Moisture uptake of TFRPs and TSPs at 300 °C	1313:1355	Moisture uptake of TFRPs and TSPs at 300 °C were only 1.4 wt% and 2.0-2.8 wt%, respectively, showing strong water-resistant ability.
32535373	8	37	from	crystallinity	1530:1542	arg1	TFRPs					1560:1564	TFRPs	1560:1564	TFRPs	1560:1564	The crystallinity of cellulose in FRPs was found higher than that of SPs, while the crystallinity of cellulose in TFRPs was found lower than that of TSPs at same process conditions.
32535373	6	38	theme	highest	1124:1130	arg1	densities					1137:1145	The highest true densities	1120:1145	The highest true densities (i.e. 2.40 and 1.85 g/cm3)	1120:1172	The highest true densities (i.e. 2.40 and 1.85 g/cm3) and porosities (i.e. 52 and 65 v %) of TFRPs and TSPs were achieved at 300 °C and 120 min, much higher than those of un-torrefied pellets.
32535373	5	39	theme	volumetric	926:935	arg1	densities					944:952	the volumetric energy densities	922:952	the volumetric energy densities of TFRPs	922:961	Increasing torrefaction temperature and residence time, the volumetric energy densities of TFRPs increased from 25.69 (at 200 °C and 15 min) to 27.59 kJ/m3 (at 300 °C and 120 min), while those of TSPs correspondingly decreased from 20.81 to 16.69 kJ/m3.
32535373	4	40	theme	energy	692:697	arg1	1.27					714:717	1.27	714:717	1.27	714:717	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	4	40	theme	energy	692:697	arg1	ratio					707:711	energy density ratio	692:711	energy density ratio (1.27)	692:718	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	8	41	theme	same	1603:1606	arg1	conditions					1616:1625	same process conditions	1603:1625	same process conditions	1603:1625	The crystallinity of cellulose in FRPs was found higher than that of SPs, while the crystallinity of cellulose in TFRPs was found lower than that of TSPs at same process conditions.
32535373	1	42	theme	fuel	227:230	arg1	pellets					232:238	fuel pellets	227:238	fuel pellets	227:238	Torrefaction integrated with pelletization has gained increasingly interest as it enhances the characteristics of fuel pellets (e.g. hydrophobicity and energy density).
32535373	7	43	theme	strong	1414:1419	arg1	ability					1437:1443	strong water-resistant ability	1414:1443	strong water-resistant ability	1414:1443	Moisture uptake of TFRPs and TSPs at 300 °C were only 1.4 wt% and 2.0-2.8 wt%, respectively, showing strong water-resistant ability.
32535373	1	44	theme	pellets	232:238	arg1	characteristics					208:222	the characteristics	204:222	the characteristics of fuel pellets	204:238	Torrefaction integrated with pelletization has gained increasingly interest as it enhances the characteristics of fuel pellets (e.g. hydrophobicity and energy density).
32535373	4	45	theme	torrefied	796:804	arg1	pellets					814:820	torrefied sawdust pellets	796:820	torrefied sawdust pellets	796:820	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	2	46	theme	tubular	401:407	arg1	furnace					417:423	tubular reactor furnace	401:423	tubular reactor furnace	401:423	In current study, torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs) was performed by employing tubular reactor furnace, and quality of pellets was compared.
32535373	8	47	theme	cellulose	1467:1475	arg1	crystallinity					1450:1462	The crystallinity	1446:1462	The crystallinity of cellulose in FRPs	1446:1483	The crystallinity of cellulose in FRPs was found higher than that of SPs, while the crystallinity of cellulose in TFRPs was found lower than that of TSPs at same process conditions.
32535373	3	48	theme	residence	603:611	arg1	time					613:616	residence time	603:616	residence time	603:616	The characteristics of both types of pellets were significantly improved with increasing torrefaction temperature from 200 °C to 300 °C and residence time from 15 min to 30 min.
32535373	9	49	theme	O-H	1645:1647	arg1	bond					1649:1652	O-H bond	1645:1652	O-H bond	1645:1652	FTIR showed that O-H bond was destroyed after torrefaction for both FRP and SP.
32535373	4	50	theme	residue	743:749	arg1	TFRPs					760:764	TFRPs	760:764	TFRPs	760:764	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	4	50	theme	residue	743:749	arg1	pellets					751:757	torrefied furfural residue pellets	724:757	torrefied furfural residue pellets (TFRPs)	724:765	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	5	51	from	120 min	1037:1043	arg1	27.59 kJ/m3					1010:1020	27.59 kJ/m3	1010:1020	27.59 kJ/m3 (at 300 °C and 120 min)	1010:1044	Increasing torrefaction temperature and residence time, the volumetric energy densities of TFRPs increased from 25.69 (at 200 °C and 15 min) to 27.59 kJ/m3 (at 300 °C and 120 min), while those of TSPs correspondingly decreased from 20.81 to 16.69 kJ/m3.
32535373	6	52	theme	TSPs	1223:1226	arg1	porosities					1178:1187	porosities	1178:1187	porosities	1178:1187	The highest true densities (i.e. 2.40 and 1.85 g/cm3) and porosities (i.e. 52 and 65 v %) of TFRPs and TSPs were achieved at 300 °C and 120 min, much higher than those of un-torrefied pellets.
32535373	6	52	theme	TSPs	1223:1226	arg1	densities					1137:1145	The highest true densities	1120:1145	The highest true densities (i.e. 2.40 and 1.85 g/cm3)	1120:1172	The highest true densities (i.e. 2.40 and 1.85 g/cm3) and porosities (i.e. 52 and 65 v %) of TFRPs and TSPs were achieved at 300 °C and 120 min, much higher than those of un-torrefied pellets.
32535373	1	53	dep	hydrophobicity	246:259	arg1	e.g.					241:244	e.g.	241:244	e.g.	241:244	Torrefaction integrated with pelletization has gained increasingly interest as it enhances the characteristics of fuel pellets (e.g. hydrophobicity and energy density).
32535373	7	54	theme	TSPs	1342:1345	arg1	uptake					1322:1327	Moisture uptake	1313:1327	Moisture uptake of TFRPs and TSPs at 300 °C	1313:1355	Moisture uptake of TFRPs and TSPs at 300 °C were only 1.4 wt% and 2.0-2.8 wt%, respectively, showing strong water-resistant ability.
32535373	2	55	theme	pellets	441:447	arg1	quality					430:436	quality	430:436	quality of pellets	430:447	In current study, torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs) was performed by employing tubular reactor furnace, and quality of pellets was compared.
32535373	1	56	dep	enhances	195:202	arg1	hydrophobicity					246:259	hydrophobicity	246:259	hydrophobicity	246:259	Torrefaction integrated with pelletization has gained increasingly interest as it enhances the characteristics of fuel pellets (e.g. hydrophobicity and energy density).
32535373	1	56	dep	enhances	195:202	arg1	density					272:278	energy density	265:278	energy density	265:278	Torrefaction integrated with pelletization has gained increasingly interest as it enhances the characteristics of fuel pellets (e.g. hydrophobicity and energy density).
32535373	4	57	theme	ratio	707:711	arg1	value					667:671	The highest lower heating value	641:671	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs)	641:827	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	6	58	theme	TFRPs	1213:1217	arg1	porosities					1178:1187	porosities	1178:1187	porosities	1178:1187	The highest true densities (i.e. 2.40 and 1.85 g/cm3) and porosities (i.e. 52 and 65 v %) of TFRPs and TSPs were achieved at 300 °C and 120 min, much higher than those of un-torrefied pellets.
32535373	6	58	theme	TFRPs	1213:1217	arg1	densities					1137:1145	The highest true densities	1120:1145	The highest true densities (i.e. 2.40 and 1.85 g/cm3)	1120:1172	The highest true densities (i.e. 2.40 and 1.85 g/cm3) and porosities (i.e. 52 and 65 v %) of TFRPs and TSPs were achieved at 300 °C and 120 min, much higher than those of un-torrefied pellets.
32535373	5	59	theme	residence	906:914	arg1	time					916:919	residence time	906:919	residence time	906:919	Increasing torrefaction temperature and residence time, the volumetric energy densities of TFRPs increased from 25.69 (at 200 °C and 15 min) to 27.59 kJ/m3 (at 300 °C and 120 min), while those of TSPs correspondingly decreased from 20.81 to 16.69 kJ/m3.
32535373	2	60	theme	furfural	316:323	arg1	FRPs					342:345	FRPs	342:345	FRPs	342:345	In current study, torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs) was performed by employing tubular reactor furnace, and quality of pellets was compared.
32535373	2	60	theme	furfural	316:323	arg1	pellets					333:339	furfural residue pellets	316:339	furfural residue pellets (FRPs)	316:346	In current study, torrefaction of furfural residue pellets (FRPs) and sawdust pellets (SPs) was performed by employing tubular reactor furnace, and quality of pellets was compared.
32535373	6	61	dep	2.40	1153:1156	arg1	i.e.					1148:1151	i.e.	1148:1151	i.e.	1148:1151	The highest true densities (i.e. 2.40 and 1.85 g/cm3) and porosities (i.e. 52 and 65 v %) of TFRPs and TSPs were achieved at 300 °C and 120 min, much higher than those of un-torrefied pellets.
32535373	0	62	theme	furfural	75:82	arg1	residue					84:90	furfural residue	75:90	furfural residue	75:90	Torrefaction subsequent to pelletization: Characterization and analysis of furfural residue and sawdust pellets.
32535373	3	63	theme	pellets	500:506	arg1	types					491:495	both types	486:495	both types of pellets	486:506	The characteristics of both types of pellets were significantly improved with increasing torrefaction temperature from 200 °C to 300 °C and residence time from 15 min to 30 min.
32535373	3	64	from	200 °C	582:587	arg1	temperature					565:575	torrefaction temperature	552:575	torrefaction temperature from 200 °C to 300 °C and residence time	552:616	The characteristics of both types of pellets were significantly improved with increasing torrefaction temperature from 200 °C to 300 °C and residence time from 15 min to 30 min.
32535373	0	65	dep	Torrefaction	0:11	arg1	Characterization					42:57	Characterization	42:57	Characterization	42:57	Torrefaction subsequent to pelletization: Characterization and analysis of furfural residue and sawdust pellets.
32535373	0	65	dep	Torrefaction	0:11	arg1	analysis					63:70	analysis	63:70	analysis	63:70	Torrefaction subsequent to pelletization: Characterization and analysis of furfural residue and sawdust pellets.
32535373	4	66	theme	23.78 MJ/kg	676:686	arg1	value					667:671	The highest lower heating value	641:671	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs)	641:827	The highest lower heating value of 23.78 MJ/kg and energy density ratio (1.27) for torrefied furfural residue pellets (TFRPs) and 26.76 MJ/kg and 1.46 for torrefied sawdust pellets (TSPs) were achieved at 300 °C and 120 min.
32535373	8	67	theme	process	1608:1614	arg1	conditions					1616:1625	same process conditions	1603:1625	same process conditions	1603:1625	The crystallinity of cellulose in FRPs was found higher than that of SPs, while the crystallinity of cellulose in TFRPs was found lower than that of TSPs at same process conditions.
32535373	1	68	theme	energy	265:270	arg1	density					272:278	energy density	265:278	energy density	265:278	Torrefaction integrated with pelletization has gained increasingly interest as it enhances the characteristics of fuel pellets (e.g. hydrophobicity and energy density).
34165303	11	0	theme	UV	2028:2029	arg1	aging					2031:2035	UV aging	2028:2035	UV aging	2028:2035	Lignin and tannin promoted the UV stability and service life of the coated paper, as a rare physical decrease was observed after UV aging for 72 h.
34165303	10	1	attach	presented	1689:1697	arg1	addition					1662:1669	addition	1662:1669	addition	1662:1669	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	10	1	attach	presented	1689:1697	arg2	paper					1683:1687	the coated paper	1672:1687	the coated paper	1672:1687	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	9	2	theme	good	1577:1580	arg1	medium					1558:1563	the culture medium	1546:1563	the culture medium	1546:1563	Besides, antibacterial activity is only available while the bacteria come in contact with the coating and no active substances were released into the culture medium, which is a good property that can keep the cargo from contamination of antibacterial agents.
34165303	9	2	theme	good	1577:1580	arg1	property					1582:1589	a good property	1575:1589	a good property that can keep the cargo from contamination of antibacterial agents	1575:1656	Besides, antibacterial activity is only available while the bacteria come in contact with the coating and no active substances were released into the culture medium, which is a good property that can keep the cargo from contamination of antibacterial agents.
34165303	4	3	theme	tannin	592:597	arg1	weight					599:604	tannin weight	592:604	tannin weight	592:604	The best ingredient ratio was: 40% lignin, 15% tannin, and 10% ZnONPs (based on tannin weight), and the as-prepared biocoating was labeled LTZn-10.
34165303	10	4	theme	wider	1874:1878	arg1	range					1892:1896	a wider temperature range	1872:1896	a wider temperature range	1872:1896	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	2	5	theme	UV	312:313	arg1	resistance					321:330	UV aging resistance	312:330	UV aging resistance	312:330	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	8	6	located	found	1318:1322	arg2	mycelium					1305:1312	mycelium	1305:1312	mycelium	1305:1312	No colony or mycelium was found in the test against Gram-negative/positive bacteria and eight common molds.
34165303	8	6	located	found	1318:1322	arg1	test					1331:1334	the test	1327:1334	the test	1327:1334	No colony or mycelium was found in the test against Gram-negative/positive bacteria and eight common molds.
34165303	8	6	located	found	1318:1322	arg2	colony					1295:1300	colony	1295:1300	colony	1295:1300	No colony or mycelium was found in the test against Gram-negative/positive bacteria and eight common molds.
34165303	11	7	theme	coated	1967:1972	arg1	paper					1974:1978	the coated paper	1963:1978	the coated paper	1963:1978	Lignin and tannin promoted the UV stability and service life of the coated paper, as a rare physical decrease was observed after UV aging for 72 h.
34165303	5	8	contain	has	913:915	arg2	resistance					936:945	favorable moisture resistance	917:945	favorable moisture resistance	917:945	After coated with LTZn-10, the tensile strength and bursting strength of the packaging were efficiently enhanced by more than 3 times and were dramatically increased by 51.6 and 5.6 times at the wet state, respectively, which reveals that the packaging has favorable moisture resistance and it can be used in high humidity environments.
34165303	5	8	contain	has	913:915	arg1	packaging					903:911	the packaging	899:911	the packaging	899:911	After coated with LTZn-10, the tensile strength and bursting strength of the packaging were efficiently enhanced by more than 3 times and were dramatically increased by 51.6 and 5.6 times at the wet state, respectively, which reveals that the packaging has favorable moisture resistance and it can be used in high humidity environments.
34165303	4	9	theme	as-prepared	616:626	arg1	biocoating					628:637	the as-prepared biocoating	612:637	the as-prepared biocoating	612:637	The best ingredient ratio was: 40% lignin, 15% tannin, and 10% ZnONPs (based on tannin weight), and the as-prepared biocoating was labeled LTZn-10.
34165303	5	10	theme	tensile	691:697	arg1	strength					699:706	tensile strength	691:706	tensile strength	691:706	After coated with LTZn-10, the tensile strength and bursting strength of the packaging were efficiently enhanced by more than 3 times and were dramatically increased by 51.6 and 5.6 times at the wet state, respectively, which reveals that the packaging has favorable moisture resistance and it can be used in high humidity environments.
34165303	11	11	theme	paper	1974:1978	arg1	stability					1933:1941	UV stability	1930:1941	UV stability	1930:1941	Lignin and tannin promoted the UV stability and service life of the coated paper, as a rare physical decrease was observed after UV aging for 72 h.
34165303	11	11	theme	paper	1974:1978	arg1	life					1955:1958	service life	1947:1958	service life	1947:1958	Lignin and tannin promoted the UV stability and service life of the coated paper, as a rare physical decrease was observed after UV aging for 72 h.
34165303	10	12	theme	thermal	1718:1724	arg1	temperature					1738:1748	thermal degradation temperature	1718:1748	thermal degradation temperature	1718:1748	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	9	13	theme	antibacterial	1637:1649	arg1	agents					1651:1656	antibacterial agents	1637:1656	antibacterial agents	1637:1656	Besides, antibacterial activity is only available while the bacteria come in contact with the coating and no active substances were released into the culture medium, which is a good property that can keep the cargo from contamination of antibacterial agents.
34165303	7	14	with	packaging	1235:1243	arg1	performance					1279:1289	excellent antibacterial/mold performance	1250:1289	excellent antibacterial/mold performance	1250:1289	Meanwhile, ZnONPs were evenly spread on the coatings, which endowed the packaging with excellent antibacterial/mold performance.
34165303	2	15	theme	moisture	256:263	arg1	resistance					265:274	moisture resistance	256:274	moisture resistance	256:274	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	11	16	dep	stability	1933:1941	arg1	the					1926:1928	the	1926:1928	the	1926:1928	Lignin and tannin promoted the UV stability and service life of the coated paper, as a rare physical decrease was observed after UV aging for 72 h.
34165303	11	17	theme	rare	1986:1989	arg1	decrease					2000:2007	a rare physical decrease	1984:2007	a rare physical decrease	1984:2007	Lignin and tannin promoted the UV stability and service life of the coated paper, as a rare physical decrease was observed after UV aging for 72 h.
34165303	9	18	theme	active	1509:1514	arg1	substances					1516:1525	no active substances	1506:1525	no active substances	1506:1525	Besides, antibacterial activity is only available while the bacteria come in contact with the coating and no active substances were released into the culture medium, which is a good property that can keep the cargo from contamination of antibacterial agents.
34165303	2	19	theme	aging	315:319	arg1	resistance					321:330	UV aging resistance	312:330	UV aging resistance	312:330	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	5	20	dep	strength	699:706	arg1	the					687:689	the	687:689	the	687:689	After coated with LTZn-10, the tensile strength and bursting strength of the packaging were efficiently enhanced by more than 3 times and were dramatically increased by 51.6 and 5.6 times at the wet state, respectively, which reveals that the packaging has favorable moisture resistance and it can be used in high humidity environments.
34165303	7	21	theme	antibacterial/mold	1260:1277	arg1	performance					1279:1289	excellent antibacterial/mold performance	1250:1289	excellent antibacterial/mold performance	1250:1289	Meanwhile, ZnONPs were evenly spread on the coatings, which endowed the packaging with excellent antibacterial/mold performance.
34165303	0	22	theme	Coatings	85:92	arg1	Preparation					11:21	Preparation	11:21	Preparation	11:21	Design and Preparation of Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings for Paper-Based Green Packaging.
34165303	0	22	theme	Coatings	85:92	arg1	Design					0:5	Design	0:5	Design	0:5	Design and Preparation of Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings for Paper-Based Green Packaging.
34165303	2	23	theme	air	281:283	arg1	permeance					285:293	low air permeance	277:293	low air permeance	277:293	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	1	24	theme	green	196:200	arg1	packaging					202:210	paper-based green packaging	184:210	paper-based green packaging	184:210	Lignin/tannin/ZnONP composite coatings were designed for paper-based green packaging.
34165303	0	25	theme	Paper-Based	98:108	arg1	Packaging					116:124	Paper-Based Green Packaging	98:124	Paper-Based Green Packaging	98:124	Design and Preparation of Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings for Paper-Based Green Packaging.
34165303	4	26	dep	%	557:557	arg1	tannin					559:564	tannin	559:564	15% tannin	555:564	The best ingredient ratio was: 40% lignin, 15% tannin, and 10% ZnONPs (based on tannin weight), and the as-prepared biocoating was labeled LTZn-10.
34165303	1	27	theme	composite	147:155	arg1	coatings					157:164	Lignin/tannin/ZnONP composite coatings	127:164	Lignin/tannin/ZnONP composite coatings	127:164	Lignin/tannin/ZnONP composite coatings were designed for paper-based green packaging.
34165303	4	28	dep	ZnONPs	575:580	arg1	based					583:587	based	583:587	based on tannin weight	583:604	The best ingredient ratio was: 40% lignin, 15% tannin, and 10% ZnONPs (based on tannin weight), and the as-prepared biocoating was labeled LTZn-10.
34165303	11	29	theme	service	1947:1953	arg1	life					1955:1958	service life	1947:1958	service life	1947:1958	Lignin and tannin promoted the UV stability and service life of the coated paper, as a rare physical decrease was observed after UV aging for 72 h.
34165303	12	30	theme	paper-based	2159:2169	arg1	fields					2187:2192	paper-based green packaging fields	2159:2192	paper-based green packaging fields	2159:2192	The function-integrated biobased coating with favorable sustainability is a good candidate to be widely used in paper-based green packaging fields.
34165303	3	31	theme	high	490:493	arg1	contents					502:509	high lignin contents	490:509	high lignin contents	490:509	Prepolymerization improved the physical properties of coatings at high lignin contents.
34165303	7	32	theme	excellent	1250:1258	arg1	performance					1279:1289	excellent antibacterial/mold performance	1250:1289	excellent antibacterial/mold performance	1250:1289	Meanwhile, ZnONPs were evenly spread on the coatings, which endowed the packaging with excellent antibacterial/mold performance.
34165303	12	33	theme	packaging	2177:2185	arg1	fields					2187:2192	paper-based green packaging fields	2159:2192	paper-based green packaging fields	2159:2192	The function-integrated biobased coating with favorable sustainability is a good candidate to be widely used in paper-based green packaging fields.
34165303	12	34	theme	good	2123:2126	arg1	candidate					2128:2136	a good candidate	2121:2136	a good candidate to be widely used in paper-based green packaging fields	2121:2192	The function-integrated biobased coating with favorable sustainability is a good candidate to be widely used in paper-based green packaging fields.
34165303	12	34	theme	good	2123:2126	arg1	coating					2080:2086	The function-integrated biobased coating	2047:2086	The function-integrated biobased coating with favorable sustainability	2047:2116	The function-integrated biobased coating with favorable sustainability is a good candidate to be widely used in paper-based green packaging fields.
34165303	3	35	theme	coatings	478:485	arg1	properties					464:473	the physical properties	451:473	the physical properties of coatings	451:485	Prepolymerization improved the physical properties of coatings at high lignin contents.
34165303	5	36	theme	favorable	917:925	arg1	resistance					936:945	favorable moisture resistance	917:945	favorable moisture resistance	917:945	After coated with LTZn-10, the tensile strength and bursting strength of the packaging were efficiently enhanced by more than 3 times and were dramatically increased by 51.6 and 5.6 times at the wet state, respectively, which reveals that the packaging has favorable moisture resistance and it can be used in high humidity environments.
34165303	5	37	theme	wet	855:857	arg1	state					859:863	the wet state	851:863	the wet state	851:863	After coated with LTZn-10, the tensile strength and bursting strength of the packaging were efficiently enhanced by more than 3 times and were dramatically increased by 51.6 and 5.6 times at the wet state, respectively, which reveals that the packaging has favorable moisture resistance and it can be used in high humidity environments.
34165303	4	38	theme	%	573:573	arg1	ZnONPs					575:580	10% ZnONPs	571:580	10% ZnONPs (based on tannin weight)	571:605	The best ingredient ratio was: 40% lignin, 15% tannin, and 10% ZnONPs (based on tannin weight), and the as-prepared biocoating was labeled LTZn-10.
34165303	12	39	theme	favorable	2093:2101	arg1	sustainability					2103:2116	favorable sustainability	2093:2116	favorable sustainability	2093:2116	The function-integrated biobased coating with favorable sustainability is a good candidate to be widely used in paper-based green packaging fields.
34165303	0	40	theme	Multiple	26:33	arg1	Coatings					85:92	Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings	26:92	Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings	26:92	Design and Preparation of Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings for Paper-Based Green Packaging.
34165303	5	41	theme	humidity	974:981	arg1	environments					983:994	high humidity environments	969:994	high humidity environments	969:994	After coated with LTZn-10, the tensile strength and bursting strength of the packaging were efficiently enhanced by more than 3 times and were dramatically increased by 51.6 and 5.6 times at the wet state, respectively, which reveals that the packaging has favorable moisture resistance and it can be used in high humidity environments.
34165303	6	42	theme	Scanning	997:1004	arg1	microscopy					1015:1024	Scanning electron microscopy	997:1024	Scanning electron microscopy (SEM)	997:1030	Scanning electron microscopy (SEM) proved that most of the pores on the paper were blocked by the coatings, which helped to decrease the air permeance by 10.3 times.
34165303	6	42	theme	Scanning	997:1004	arg1	SEM					1027:1029	SEM	1027:1029	SEM	1027:1029	Scanning electron microscopy (SEM) proved that most of the pores on the paper were blocked by the coatings, which helped to decrease the air permeance by 10.3 times.
34165303	2	43	theme	Multiple	213:220	arg1	resistance					265:274	moisture resistance	256:274	moisture resistance	256:274	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	2	43	theme	Multiple	213:220	arg1	endurance					301:309	heat endurance	296:309	heat endurance	296:309	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	2	43	theme	Multiple	213:220	arg1	properties					356:365	antibacterial/mold properties	337:365	antibacterial/mold properties	337:365	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	2	43	theme	Multiple	213:220	arg1	strength					246:253	high strength	241:253	high strength	241:253	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	2	43	theme	Multiple	213:220	arg1	permeance					285:293	low air permeance	277:293	low air permeance	277:293	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	2	43	theme	Multiple	213:220	arg1	functions					222:230	Multiple functions	213:230	Multiple functions	213:230	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	2	43	theme	Multiple	213:220	arg1	resistance					321:330	UV aging resistance	312:330	UV aging resistance	312:330	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	0	44	theme	Lignin/Tannin/ZnONP	55:73	arg1	Coatings					85:92	Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings	26:92	Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings	26:92	Design and Preparation of Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings for Paper-Based Green Packaging.
34165303	4	45	dep	%	545:545	arg1	lignin					547:552	lignin	547:552	40% lignin	543:552	The best ingredient ratio was: 40% lignin, 15% tannin, and 10% ZnONPs (based on tannin weight), and the as-prepared biocoating was labeled LTZn-10.
34165303	8	46	theme	Gram-negative/positive	1344:1365	arg1	bacteria					1367:1374	Gram-negative/positive bacteria	1344:1374	Gram-negative/positive bacteria	1344:1374	No colony or mycelium was found in the test against Gram-negative/positive bacteria and eight common molds.
34165303	10	47	theme	favorable	1790:1798	arg1	thermostability					1800:1814	favorable thermostability	1790:1814	favorable thermostability	1790:1814	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	2	48	theme	biobased	406:413	arg1	coating					415:421	one biobased coating	402:421	one biobased coating	402:421	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	10	49	theme	outstanding	1837:1847	arg1	properties					1858:1867	its outstanding physical properties	1833:1867	its outstanding physical properties	1833:1867	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	10	50	theme	coated	1676:1681	arg1	paper					1683:1687	the coated paper	1672:1687	the coated paper	1672:1687	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	2	51	theme	antibacterial/mold	337:354	arg1	properties					356:365	antibacterial/mold properties	337:365	antibacterial/mold properties	337:365	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	11	52	theme	UV	1930:1931	arg1	stability					1933:1941	UV stability	1930:1941	UV stability	1930:1941	Lignin and tannin promoted the UV stability and service life of the coated paper, as a rare physical decrease was observed after UV aging for 72 h.
34165303	10	53	theme	improved	1702:1709	arg1	Tg					1711:1712	an improved Tg	1699:1712	an improved Tg	1699:1712	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	8	54	theme	common	1386:1391	arg1	molds					1393:1397	eight common molds	1380:1397	eight common molds	1380:1397	No colony or mycelium was found in the test against Gram-negative/positive bacteria and eight common molds.
34165303	10	55	theme	temperature	1880:1890	arg1	range					1892:1896	a wider temperature range	1872:1896	a wider temperature range	1872:1896	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	10	56	theme	degradation	1726:1736	arg1	temperature					1738:1748	thermal degradation temperature	1718:1748	thermal degradation temperature	1718:1748	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	9	57	theme	antibacterial	1409:1421	arg1	activity					1423:1430	antibacterial activity	1409:1430	antibacterial activity	1409:1430	Besides, antibacterial activity is only available while the bacteria come in contact with the coating and no active substances were released into the culture medium, which is a good property that can keep the cargo from contamination of antibacterial agents.
34165303	4	58	theme	best	516:519	arg1	%					545:545	40%	543:545	40% lignin	543:552	The best ingredient ratio was: 40% lignin, 15% tannin, and 10% ZnONPs (based on tannin weight), and the as-prepared biocoating was labeled LTZn-10.
34165303	4	58	theme	best	516:519	arg1	ratio					532:536	The best ingredient ratio	512:536	The best ingredient ratio	512:536	The best ingredient ratio was: 40% lignin, 15% tannin, and 10% ZnONPs (based on tannin weight), and the as-prepared biocoating was labeled LTZn-10.
34165303	9	59	with	contact	1477:1483	arg1	coating					1494:1500	the coating	1490:1500	the coating	1490:1500	Besides, antibacterial activity is only available while the bacteria come in contact with the coating and no active substances were released into the culture medium, which is a good property that can keep the cargo from contamination of antibacterial agents.
34165303	9	60	theme	agents	1651:1656	arg1	contamination					1620:1632	contamination	1620:1632	contamination of antibacterial agents	1620:1656	Besides, antibacterial activity is only available while the bacteria come in contact with the coating and no active substances were released into the culture medium, which is a good property that can keep the cargo from contamination of antibacterial agents.
34165303	12	61	theme	function-integrated	2051:2069	arg1	candidate					2128:2136	a good candidate	2121:2136	a good candidate to be widely used in paper-based green packaging fields	2121:2192	The function-integrated biobased coating with favorable sustainability is a good candidate to be widely used in paper-based green packaging fields.
34165303	12	61	theme	function-integrated	2051:2069	arg1	coating					2080:2086	The function-integrated biobased coating	2047:2086	The function-integrated biobased coating with favorable sustainability	2047:2116	The function-integrated biobased coating with favorable sustainability is a good candidate to be widely used in paper-based green packaging fields.
34165303	2	62	theme	heat	296:299	arg1	endurance					301:309	heat endurance	296:309	heat endurance	296:309	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	11	63	theme	physical	1991:1998	arg1	decrease					2000:2007	a rare physical decrease	1984:2007	a rare physical decrease	1984:2007	Lignin and tannin promoted the UV stability and service life of the coated paper, as a rare physical decrease was observed after UV aging for 72 h.
34165303	6	64	theme	air	1134:1136	arg1	permeance					1138:1146	the air permeance	1130:1146	the air permeance	1130:1146	Scanning electron microscopy (SEM) proved that most of the pores on the paper were blocked by the coatings, which helped to decrease the air permeance by 10.3 times.
34165303	5	65	theme	packaging	737:745	arg1	strength					699:706	tensile strength	691:706	tensile strength	691:706	After coated with LTZn-10, the tensile strength and bursting strength of the packaging were efficiently enhanced by more than 3 times and were dramatically increased by 51.6 and 5.6 times at the wet state, respectively, which reveals that the packaging has favorable moisture resistance and it can be used in high humidity environments.
34165303	5	65	theme	packaging	737:745	arg1	strength					721:728	bursting strength	712:728	bursting strength	712:728	After coated with LTZn-10, the tensile strength and bursting strength of the packaging were efficiently enhanced by more than 3 times and were dramatically increased by 51.6 and 5.6 times at the wet state, respectively, which reveals that the packaging has favorable moisture resistance and it can be used in high humidity environments.
34165303	1	66	theme	paper-based	184:194	arg1	packaging					202:210	paper-based green packaging	184:210	paper-based green packaging	184:210	Lignin/tannin/ZnONP composite coatings were designed for paper-based green packaging.
34165303	0	67	theme	Green	110:114	arg1	Packaging					116:124	Paper-Based Green Packaging	98:124	Paper-Based Green Packaging	98:124	Design and Preparation of Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings for Paper-Based Green Packaging.
34165303	9	68	from	contamination	1620:1632	arg1	cargo					1609:1613	the cargo	1605:1613	the cargo from contamination of antibacterial agents	1605:1656	Besides, antibacterial activity is only available while the bacteria come in contact with the coating and no active substances were released into the culture medium, which is a good property that can keep the cargo from contamination of antibacterial agents.
34165303	5	69	theme	bursting	712:719	arg1	strength					721:728	bursting strength	712:728	bursting strength	712:728	After coated with LTZn-10, the tensile strength and bursting strength of the packaging were efficiently enhanced by more than 3 times and were dramatically increased by 51.6 and 5.6 times at the wet state, respectively, which reveals that the packaging has favorable moisture resistance and it can be used in high humidity environments.
34165303	5	70	theme	moisture	927:934	arg1	resistance					936:945	favorable moisture resistance	917:945	favorable moisture resistance	917:945	After coated with LTZn-10, the tensile strength and bursting strength of the packaging were efficiently enhanced by more than 3 times and were dramatically increased by 51.6 and 5.6 times at the wet state, respectively, which reveals that the packaging has favorable moisture resistance and it can be used in high humidity environments.
34165303	12	71	theme	green	2171:2175	arg1	fields					2187:2192	paper-based green packaging fields	2159:2192	paper-based green packaging fields	2159:2192	The function-integrated biobased coating with favorable sustainability is a good candidate to be widely used in paper-based green packaging fields.
34165303	3	72	theme	lignin	495:500	arg1	contents					502:509	high lignin contents	490:509	high lignin contents	490:509	Prepolymerization improved the physical properties of coatings at high lignin contents.
34165303	4	73	theme	ingredient	521:530	arg1	%					545:545	40%	543:545	40% lignin	543:552	The best ingredient ratio was: 40% lignin, 15% tannin, and 10% ZnONPs (based on tannin weight), and the as-prepared biocoating was labeled LTZn-10.
34165303	4	73	theme	ingredient	521:530	arg1	ratio					532:536	The best ingredient ratio	512:536	The best ingredient ratio	512:536	The best ingredient ratio was: 40% lignin, 15% tannin, and 10% ZnONPs (based on tannin weight), and the as-prepared biocoating was labeled LTZn-10.
34165303	4	74	theme	10	571:572	arg1	%					573:573	%	573:573	%	573:573	The best ingredient ratio was: 40% lignin, 15% tannin, and 10% ZnONPs (based on tannin weight), and the as-prepared biocoating was labeled LTZn-10.
34165303	12	75	with	coating	2080:2086	arg1	sustainability					2103:2116	favorable sustainability	2093:2116	favorable sustainability	2093:2116	The function-integrated biobased coating with favorable sustainability is a good candidate to be widely used in paper-based green packaging fields.
34165303	1	76	theme	Lignin/tannin/ZnONP	127:145	arg1	coatings					157:164	Lignin/tannin/ZnONP composite coatings	127:164	Lignin/tannin/ZnONP composite coatings	127:164	Lignin/tannin/ZnONP composite coatings were designed for paper-based green packaging.
34165303	2	77	theme	low	277:279	arg1	permeance					285:293	low air permeance	277:293	low air permeance	277:293	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	0	78	theme	Function-Integrated	35:53	arg1	Coatings					85:92	Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings	26:92	Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings	26:92	Design and Preparation of Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings for Paper-Based Green Packaging.
34165303	5	79	theme	high	969:972	arg1	environments					983:994	high humidity environments	969:994	high humidity environments	969:994	After coated with LTZn-10, the tensile strength and bursting strength of the packaging were efficiently enhanced by more than 3 times and were dramatically increased by 51.6 and 5.6 times at the wet state, respectively, which reveals that the packaging has favorable moisture resistance and it can be used in high humidity environments.
34165303	6	80	theme	electron	1006:1013	arg1	microscopy					1015:1024	Scanning electron microscopy	997:1024	Scanning electron microscopy (SEM)	997:1030	Scanning electron microscopy (SEM) proved that most of the pores on the paper were blocked by the coatings, which helped to decrease the air permeance by 10.3 times.
34165303	6	80	theme	electron	1006:1013	arg1	SEM					1027:1029	SEM	1027:1029	SEM	1027:1029	Scanning electron microscopy (SEM) proved that most of the pores on the paper were blocked by the coatings, which helped to decrease the air permeance by 10.3 times.
34165303	10	81	theme	coated	1771:1776	arg1	package					1778:1784	the coated package	1767:1784	the coated package	1767:1784	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	0	82	theme	Composite	75:83	arg1	Coatings					85:92	Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings	26:92	Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings	26:92	Design and Preparation of Multiple Function-Integrated Lignin/Tannin/ZnONP Composite Coatings for Paper-Based Green Packaging.
34165303	3	83	theme	physical	455:462	arg1	properties					464:473	the physical properties	451:473	the physical properties of coatings	451:485	Prepolymerization improved the physical properties of coatings at high lignin contents.
34165303	5	84	used	used	961:964	arg2	it					951:952	it	951:952	it	951:952	After coated with LTZn-10, the tensile strength and bursting strength of the packaging were efficiently enhanced by more than 3 times and were dramatically increased by 51.6 and 5.6 times at the wet state, respectively, which reveals that the packaging has favorable moisture resistance and it can be used in high humidity environments.
34165303	9	85	theme	culture	1550:1556	arg1	medium					1558:1563	the culture medium	1546:1563	the culture medium	1546:1563	Besides, antibacterial activity is only available while the bacteria come in contact with the coating and no active substances were released into the culture medium, which is a good property that can keep the cargo from contamination of antibacterial agents.
34165303	9	85	theme	culture	1550:1556	arg1	property					1582:1589	a good property	1575:1589	a good property that can keep the cargo from contamination of antibacterial agents	1575:1656	Besides, antibacterial activity is only available while the bacteria come in contact with the coating and no active substances were released into the culture medium, which is a good property that can keep the cargo from contamination of antibacterial agents.
34165303	2	86	theme	high	241:244	arg1	strength					246:253	high strength	241:253	high strength	241:253	Multiple functions, such as high strength, moisture resistance, low air permeance, heat endurance, UV aging resistance, and antibacterial/mold properties, were successfully integrated into one biobased coating.
34165303	10	87	contain	has	1786:1788	arg1	package					1778:1784	the coated package	1767:1784	the coated package	1767:1784	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	10	87	contain	has	1786:1788	arg2	thermostability					1800:1814	favorable thermostability	1790:1814	favorable thermostability	1790:1814	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	10	88	theme	physical	1849:1856	arg1	properties					1858:1867	its outstanding physical properties	1833:1867	its outstanding physical properties	1833:1867	In addition, the coated paper presented an improved Tg and thermal degradation temperature, indicating that the coated package has favorable thermostability and can maintain its outstanding physical properties in a wider temperature range.
34165303	12	89	theme	biobased	2071:2078	arg1	candidate					2128:2136	a good candidate	2121:2136	a good candidate to be widely used in paper-based green packaging fields	2121:2192	The function-integrated biobased coating with favorable sustainability is a good candidate to be widely used in paper-based green packaging fields.
34165303	12	89	theme	biobased	2071:2078	arg1	coating					2080:2086	The function-integrated biobased coating	2047:2086	The function-integrated biobased coating with favorable sustainability	2047:2116	The function-integrated biobased coating with favorable sustainability is a good candidate to be widely used in paper-based green packaging fields.
34165303	6	90	from	pores	1056:1060	arg1	paper					1069:1073	the paper	1065:1073	the paper	1065:1073	Scanning electron microscopy (SEM) proved that most of the pores on the paper were blocked by the coatings, which helped to decrease the air permeance by 10.3 times.
32240692	1	0	theme	surface	229:235	arg1	properties					244:253	surface charge properties	229:253	surface charge properties	229:253	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	8	1	theme	conformational	1543:1556	arg1	structure					1558:1566	OVA conformational structure	1539:1566	OVA conformational structure	1539:1566	CD and SDS-PAGE showed that OVA conformational structure did not change after release from the nanoparticles.
32240692	3	2	theme	intestinal	931:940	arg1	fluid					942:946	simulated intestinal fluid	921:946	simulated intestinal fluid	921:946	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	3	theme	in vitro	958:965	arg1	release					971:977	in vitro OVA release	958:977	in vitro OVA release	958:977	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	4	4	theme	nanoparticles	1006:1018	arg1	size					1020:1023	Unmodified nanoparticles size	995:1023	Unmodified nanoparticles size of 146 nm	995:1033	Unmodified nanoparticles size of 146 nm increased to 175-321 nm after modification while modified particles remained intact for more than 3 h in SGF and 96 h in SIF (DLS and SEM).
32240692	3	5	theme	scanning	689:696	arg1	microscopy					707:716	scanning electron microscopy	689:716	scanning electron microscopy (SEM)	689:722	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	5	theme	scanning	689:696	arg1	scattering					605:614	dynamic light scattering	591:614	dynamic light scattering (DLS)	591:620	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	5	theme	scanning	689:696	arg1	SEM					719:721	SEM	719:721	SEM	719:721	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	1	6	theme	target	359:364	arg1	site					374:377	target mucosal site	359:377	target mucosal site	359:377	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	0	7	theme	Vaccine	114:120	arg1	Delivery					122:129	Potential Oral Mucosa Vaccine Delivery	92:129	Potential Oral Mucosa Vaccine Delivery	92:129	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	6	8	theme	OVA	1328:1330	arg1	encapsulation					1332:1344	highest OVA encapsulation	1320:1344	highest OVA encapsulation	1320:1344	Both showed highest OVA encapsulation at 67% and 73%, and sustained OVA release in SIF (96 h) at 65% and 64% respectively.
32240692	1	9	theme	silica	185:190	arg1	nanoparticles					192:204	matter (MCM)-41 silica nanoparticles	169:204	matter (MCM)-41 silica nanoparticles	169:204	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	3	10	from	release	971:977	arg1	fluid					942:946	simulated intestinal fluid	921:946	simulated intestinal fluid	921:946	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	10	from	release	971:977	arg1	SGF					912:914	SGF	912:914	SGF	912:914	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	10	from	release	971:977	arg1	fluid					905:909	simulated gastric fluid	887:909	simulated gastric fluid (SGF)	887:915	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	10	from	release	971:977	arg1	SIF					949:951	SIF	949:951	SIF	949:951	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	2	11	theme	model	540:544	arg1	antigen					546:552	model antigen	540:552	model antigen	540:552	We report the production and characterization of polymer and amine modified MCM-41 type silica nanoparticles for oral antigen delivery using ovalbumin (OVA) as model antigen.
32240692	1	12	dep	properties	244:253	arg1	efficiency					272:281	antigen loading efficiency	256:281	antigen loading efficiency	256:281	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	1	12	dep	properties	244:253	arg1	e.g.					224:227	e.g.	224:227	e.g.	224:227	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	7	13	theme	BET	1431:1433	arg1	results					1435:1441	BET results	1431:1441	BET results	1431:1441	BET results showed that nanopores were not blocked during surface modification.
32240692	0	14	theme	MCM	54:56	arg1	Nanoparticles					74:86	Matter (MCM)-41 Type Silica Nanoparticles	46:86	Matter (MCM)-41 Type Silica Nanoparticles	46:86	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	3	15	theme	light	599:603	arg1	DLS					617:619	DLS	617:619	DLS	617:619	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	15	theme	light	599:603	arg1	analysis					754:761	Brunauer-Emmett-Teller (BET) analysis	725:761	Brunauer-Emmett-Teller (BET) analysis	725:761	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	15	theme	light	599:603	arg1	diffraction					670:680	X-ray diffraction	664:680	X-ray diffraction (XRD)	664:686	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	15	theme	light	599:603	arg1	dichroism					773:781	circular dichroism	764:781	circular dichroism (CD)	764:786	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	15	theme	light	599:603	arg1	dodecyl					796:802	sodium dodecyl	789:802	sodium dodecyl	789:802	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	15	theme	light	599:603	arg1	calorimetry					645:655	differential scanning calorimetry	623:655	differential scanning calorimetry (DSC)	623:661	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	15	theme	light	599:603	arg1	microscopy					707:716	scanning electron microscopy	689:716	scanning electron microscopy (SEM)	689:722	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	15	theme	light	599:603	arg1	scattering					605:614	dynamic light scattering	591:614	dynamic light scattering (DLS)	591:620	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	16	theme	gel	827:829	arg1	SDS-PAGE					848:855	SDS-PAGE	848:855	SDS-PAGE	848:855	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	16	theme	gel	827:829	arg1	electrophoresis					831:845	dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis	591:845	dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)	591:856	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	2	17	theme	silica	468:473	arg1	nanoparticles					475:487	modified MCM-41 type silica nanoparticles	447:487	modified MCM-41 type silica nanoparticles	447:487	We report the production and characterization of polymer and amine modified MCM-41 type silica nanoparticles for oral antigen delivery using ovalbumin (OVA) as model antigen.
32240692	4	18	theme	modified	1084:1091	arg1	particles					1093:1101	modified particles	1084:1101	modified particles	1084:1101	Unmodified nanoparticles size of 146 nm increased to 175-321 nm after modification while modified particles remained intact for more than 3 h in SGF and 96 h in SIF (DLS and SEM).
32240692	1	19	theme	GIT	318:320	arg1	environment					322:332	harsh GIT environment	312:332	harsh GIT environment	312:332	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	1	20	theme	mobile	147:152	arg1	composition					154:164	mobile composition	147:164	mobile composition of matter (MCM)-41 silica nanoparticles	147:204	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	0	21	theme	Silica	67:72	arg1	Nanoparticles					74:86	Matter (MCM)-41 Type Silica Nanoparticles	46:86	Matter (MCM)-41 Type Silica Nanoparticles	46:86	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	7	22	theme	surface	1489:1495	arg1	modification					1497:1508	surface modification	1489:1508	surface modification	1489:1508	BET results showed that nanopores were not blocked during surface modification.
32240692	2	23	theme	antigen	498:504	arg1	delivery					506:513	oral antigen delivery	493:513	oral antigen delivery using ovalbumin (OVA) as model antigen	493:552	We report the production and characterization of polymer and amine modified MCM-41 type silica nanoparticles for oral antigen delivery using ovalbumin (OVA) as model antigen.
32240692	2	24	theme	polymer	429:435	arg1	characterization					409:424	characterization	409:424	characterization	409:424	We report the production and characterization of polymer and amine modified MCM-41 type silica nanoparticles for oral antigen delivery using ovalbumin (OVA) as model antigen.
32240692	2	24	theme	polymer	429:435	arg1	production					394:403	production	394:403	production	394:403	We report the production and characterization of polymer and amine modified MCM-41 type silica nanoparticles for oral antigen delivery using ovalbumin (OVA) as model antigen.
32240692	5	25	theme	chitosan	1226:1233	arg1	glycol					1209:1214	polyethylene glycol	1196:1214	polyethylene glycol (PEG)	1196:1220	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	5	25	theme	chitosan	1226:1233	arg1	nanoparticles					1244:1256	chitosan modified nanoparticles	1226:1256	chitosan modified nanoparticles	1226:1256	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	5	25	theme	chitosan	1226:1233	arg1	candidates					1271:1280	potential candidates	1261:1280	potential candidates for oral mucosa delivery	1261:1305	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	0	26	theme	Surface	0:6	arg1	Modification					8:19	Surface Modification	0:19	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.	0:130	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	5	27	theme	polyethylene	1196:1207	arg1	glycol					1209:1214	polyethylene glycol	1196:1214	polyethylene glycol (PEG)	1196:1220	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	5	27	theme	polyethylene	1196:1207	arg1	candidates					1271:1280	potential candidates	1261:1280	potential candidates for oral mucosa delivery	1261:1305	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	5	27	theme	polyethylene	1196:1207	arg1	PEG					1217:1219	PEG	1217:1219	PEG	1217:1219	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	5	27	theme	polyethylene	1196:1207	arg1	nanoparticles					1244:1256	chitosan modified nanoparticles	1226:1256	chitosan modified nanoparticles	1226:1256	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	6	28	theme	highest	1320:1326	arg1	encapsulation					1332:1344	highest OVA encapsulation	1320:1344	highest OVA encapsulation	1320:1344	Both showed highest OVA encapsulation at 67% and 73%, and sustained OVA release in SIF (96 h) at 65% and 64% respectively.
32240692	1	29	theme	loading	264:270	arg1	efficiency					272:281	antigen loading efficiency	256:281	antigen loading efficiency	256:281	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	3	30	theme	mucin	859:863	arg1	binding					865:871	mucin binding	859:871	mucin binding	859:871	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	2	31	theme	MCM-41	456:461	arg1	nanoparticles					475:487	modified MCM-41 type silica nanoparticles	447:487	modified MCM-41 type silica nanoparticles	447:487	We report the production and characterization of polymer and amine modified MCM-41 type silica nanoparticles for oral antigen delivery using ovalbumin (OVA) as model antigen.
32240692	3	32	theme	differential	623:634	arg1	calorimetry					645:655	differential scanning calorimetry	623:655	differential scanning calorimetry (DSC)	623:661	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	32	theme	differential	623:634	arg1	scattering					605:614	dynamic light scattering	591:614	dynamic light scattering (DLS)	591:620	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	32	theme	differential	623:634	arg1	DSC					658:660	DSC	658:660	DSC	658:660	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	0	33	theme	Composition	31:41	arg1	Modification					8:19	Surface Modification	0:19	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.	0:130	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	3	34	theme	gastric	897:903	arg1	SGF					912:914	SGF	912:914	SGF	912:914	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	34	theme	gastric	897:903	arg1	fluid					905:909	simulated gastric fluid	887:909	simulated gastric fluid (SGF)	887:915	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	34	theme	gastric	897:903	arg1	SIF					949:951	SIF	949:951	SIF	949:951	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	2	35	theme	amine	441:445	arg1	characterization					409:424	characterization	409:424	characterization	409:424	We report the production and characterization of polymer and amine modified MCM-41 type silica nanoparticles for oral antigen delivery using ovalbumin (OVA) as model antigen.
32240692	2	35	theme	amine	441:445	arg1	production					394:403	production	394:403	production	394:403	We report the production and characterization of polymer and amine modified MCM-41 type silica nanoparticles for oral antigen delivery using ovalbumin (OVA) as model antigen.
32240692	2	36	dep	production	394:403	arg1	the					390:392	the	390:392	the	390:392	We report the production and characterization of polymer and amine modified MCM-41 type silica nanoparticles for oral antigen delivery using ovalbumin (OVA) as model antigen.
32240692	0	37	theme	Matter	46:51	arg1	Nanoparticles					74:86	Matter (MCM)-41 Type Silica Nanoparticles	46:86	Matter (MCM)-41 Type Silica Nanoparticles	46:86	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	0	38	mod	Modification	8:19	arg3	Surface					0:6	Surface Modification	0:19	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.	0:130	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	0	38	mod	Modification	8:19	arg1	Composition					31:41	Mobile Composition	24:41	Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles	24:86	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	5	39	theme	mucosa	1291:1296	arg1	delivery					1298:1305	oral mucosa delivery	1286:1305	oral mucosa delivery	1286:1305	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	1	40	theme	nanoparticles	192:204	arg1	composition					154:164	mobile composition	147:164	mobile composition of matter (MCM)-41 silica nanoparticles	147:204	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	4	41	theme	Unmodified	995:1004	arg1	size					1020:1023	Unmodified nanoparticles size	995:1023	Unmodified nanoparticles size of 146 nm	995:1033	Unmodified nanoparticles size of 146 nm increased to 175-321 nm after modification while modified particles remained intact for more than 3 h in SGF and 96 h in SIF (DLS and SEM).
32240692	5	42	theme	potential	1261:1269	arg1	glycol					1209:1214	polyethylene glycol	1196:1214	polyethylene glycol (PEG)	1196:1220	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	5	42	theme	potential	1261:1269	arg1	nanoparticles					1244:1256	chitosan modified nanoparticles	1226:1256	chitosan modified nanoparticles	1226:1256	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	5	42	theme	potential	1261:1269	arg1	candidates					1271:1280	potential candidates	1261:1280	potential candidates for oral mucosa delivery	1261:1305	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	1	43	theme	charge	237:242	arg1	properties					244:253	surface charge properties	229:253	surface charge properties	229:253	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	3	44	theme	simulated	921:929	arg1	fluid					942:946	simulated intestinal fluid	921:946	simulated intestinal fluid	921:946	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	8	45	theme	OVA	1539:1541	arg1	structure					1558:1566	OVA conformational structure	1539:1566	OVA conformational structure	1539:1566	CD and SDS-PAGE showed that OVA conformational structure did not change after release from the nanoparticles.
32240692	1	46	theme	composition	154:164	arg1	Development					132:142	Development	132:142	Development of mobile composition of matter (MCM)-41 silica nanoparticles	132:204	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	3	47	from	electrophoresis	831:845	arg1	fluid					942:946	simulated intestinal fluid	921:946	simulated intestinal fluid	921:946	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	47	from	electrophoresis	831:845	arg1	SGF					912:914	SGF	912:914	SGF	912:914	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	47	from	electrophoresis	831:845	arg1	fluid					905:909	simulated gastric fluid	887:909	simulated gastric fluid (SGF)	887:915	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	47	from	electrophoresis	831:845	arg1	SIF					949:951	SIF	949:951	SIF	949:951	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	8	48	from	nanoparticles	1606:1618	arg1	release					1589:1595	release	1589:1595	release from the nanoparticles	1589:1618	CD and SDS-PAGE showed that OVA conformational structure did not change after release from the nanoparticles.
32240692	1	49	theme	matter	169:174	arg1	nanoparticles					192:204	matter (MCM)-41 silica nanoparticles	169:204	matter (MCM)-41 silica nanoparticles	169:204	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	0	50	theme	Mucosa	107:112	arg1	Delivery					122:129	Potential Oral Mucosa Vaccine Delivery	92:129	Potential Oral Mucosa Vaccine Delivery	92:129	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	1	51	theme	MCM	177:179	arg1	nanoparticles					192:204	matter (MCM)-41 silica nanoparticles	169:204	matter (MCM)-41 silica nanoparticles	169:204	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	4	52	theme	146 nm	1028:1033	arg1	size					1020:1023	Unmodified nanoparticles size	995:1023	Unmodified nanoparticles size of 146 nm	995:1033	Unmodified nanoparticles size of 146 nm increased to 175-321 nm after modification while modified particles remained intact for more than 3 h in SGF and 96 h in SIF (DLS and SEM).
32240692	3	53	theme	electron	698:705	arg1	microscopy					707:716	scanning electron microscopy	689:716	scanning electron microscopy (SEM)	689:722	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	53	theme	electron	698:705	arg1	scattering					605:614	dynamic light scattering	591:614	dynamic light scattering (DLS)	591:620	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	53	theme	electron	698:705	arg1	SEM					719:721	SEM	719:721	SEM	719:721	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	1	54	theme	mucosal	366:372	arg1	site					374:377	target mucosal site	359:377	target mucosal site	359:377	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	6	55	theme	OVA	1376:1378	arg1	release					1380:1386	OVA release	1376:1386	OVA release in SIF (96 h)	1376:1400	Both showed highest OVA encapsulation at 67% and 73%, and sustained OVA release in SIF (96 h) at 65% and 64% respectively.
32240692	3	56	from	binding	865:871	arg1	fluid					942:946	simulated intestinal fluid	921:946	simulated intestinal fluid	921:946	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	56	from	binding	865:871	arg1	SGF					912:914	SGF	912:914	SGF	912:914	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	56	from	binding	865:871	arg1	fluid					905:909	simulated gastric fluid	887:909	simulated gastric fluid (SGF)	887:915	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	56	from	binding	865:871	arg1	SIF					949:951	SIF	949:951	SIF	949:951	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	1	57	from	site	374:377	arg1	environment					322:332	harsh GIT environment	312:332	harsh GIT environment	312:332	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	1	57	from	site	374:377	arg1	release					348:354	effective release	338:354	effective release at target mucosal site	338:377	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	1	57	from	site	374:377	arg1	enzymes					300:306	enzymes	300:306	enzymes	300:306	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	3	58	from	stability	874:882	arg1	fluid					942:946	simulated intestinal fluid	921:946	simulated intestinal fluid	921:946	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	58	from	stability	874:882	arg1	SGF					912:914	SGF	912:914	SGF	912:914	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	58	from	stability	874:882	arg1	fluid					905:909	simulated gastric fluid	887:909	simulated gastric fluid (SGF)	887:915	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	58	from	stability	874:882	arg1	SIF					949:951	SIF	949:951	SIF	949:951	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	59	theme	sodium	789:794	arg1	scattering					605:614	dynamic light scattering	591:614	dynamic light scattering (DLS)	591:620	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	59	theme	sodium	789:794	arg1	dodecyl					796:802	sodium dodecyl	789:802	sodium dodecyl	789:802	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	5	60	theme	Mucin	1175:1179	arg1	binding					1181:1187	Mucin binding	1175:1187	Mucin binding	1175:1187	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	3	61	theme	dynamic	591:597	arg1	DLS					617:619	DLS	617:619	DLS	617:619	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	61	theme	dynamic	591:597	arg1	analysis					754:761	Brunauer-Emmett-Teller (BET) analysis	725:761	Brunauer-Emmett-Teller (BET) analysis	725:761	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	61	theme	dynamic	591:597	arg1	diffraction					670:680	X-ray diffraction	664:680	X-ray diffraction (XRD)	664:686	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	61	theme	dynamic	591:597	arg1	dichroism					773:781	circular dichroism	764:781	circular dichroism (CD)	764:786	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	61	theme	dynamic	591:597	arg1	dodecyl					796:802	sodium dodecyl	789:802	sodium dodecyl	789:802	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	61	theme	dynamic	591:597	arg1	calorimetry					645:655	differential scanning calorimetry	623:655	differential scanning calorimetry (DSC)	623:661	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	61	theme	dynamic	591:597	arg1	microscopy					707:716	scanning electron microscopy	689:716	scanning electron microscopy (SEM)	689:722	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	61	theme	dynamic	591:597	arg1	scattering					605:614	dynamic light scattering	591:614	dynamic light scattering (DLS)	591:620	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	62	theme	BET	749:751	arg1	analysis					754:761	Brunauer-Emmett-Teller (BET) analysis	725:761	Brunauer-Emmett-Teller (BET) analysis	725:761	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	62	theme	BET	749:751	arg1	scattering					605:614	dynamic light scattering	591:614	dynamic light scattering (DLS)	591:620	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	0	63	theme	Type	62:65	arg1	Nanoparticles					74:86	Matter (MCM)-41 Type Silica Nanoparticles	46:86	Matter (MCM)-41 Type Silica Nanoparticles	46:86	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	1	64	theme	harsh	312:316	arg1	environment					322:332	harsh GIT environment	312:332	harsh GIT environment	312:332	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	2	65	theme	type	463:466	arg1	nanoparticles					475:487	modified MCM-41 type silica nanoparticles	447:487	modified MCM-41 type silica nanoparticles	447:487	We report the production and characterization of polymer and amine modified MCM-41 type silica nanoparticles for oral antigen delivery using ovalbumin (OVA) as model antigen.
32240692	0	66	theme	Nanoparticles	74:86	arg1	Composition					31:41	Mobile Composition	24:41	Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles	24:86	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	3	67	theme	OVA	967:969	arg1	release					971:977	in vitro OVA release	958:977	in vitro OVA release	958:977	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	0	68	dep	Potential	92:100	arg1	Oral					102:105	Oral	102:105	Oral	102:105	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	3	69	theme	sulfate-polyacrylamide	804:825	arg1	SDS-PAGE					848:855	SDS-PAGE	848:855	SDS-PAGE	848:855	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	69	theme	sulfate-polyacrylamide	804:825	arg1	electrophoresis					831:845	dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis	591:845	dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)	591:856	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	70	theme	circular	764:771	arg1	scattering					605:614	dynamic light scattering	591:614	dynamic light scattering (DLS)	591:620	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	70	theme	circular	764:771	arg1	CD					784:785	CD	784:785	CD	784:785	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	70	theme	circular	764:771	arg1	dichroism					773:781	circular dichroism	764:781	circular dichroism (CD)	764:786	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	0	71	theme	Potential	92:100	arg1	Delivery					122:129	Potential Oral Mucosa Vaccine Delivery	92:129	Potential Oral Mucosa Vaccine Delivery	92:129	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	1	72	theme	effective	338:346	arg1	release					348:354	effective release	338:354	effective release at target mucosal site	338:377	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	2	73	theme	oral	493:496	arg1	delivery					506:513	oral antigen delivery	493:513	oral antigen delivery using ovalbumin (OVA) as model antigen	493:552	We report the production and characterization of polymer and amine modified MCM-41 type silica nanoparticles for oral antigen delivery using ovalbumin (OVA) as model antigen.
32240692	2	74	dep	polymer	429:435	arg1	nanoparticles					475:487	modified MCM-41 type silica nanoparticles	447:487	modified MCM-41 type silica nanoparticles	447:487	We report the production and characterization of polymer and amine modified MCM-41 type silica nanoparticles for oral antigen delivery using ovalbumin (OVA) as model antigen.
32240692	6	75	from	release	1380:1386	arg1	96 h					1396:1399	96 h	1396:1399	96 h	1396:1399	Both showed highest OVA encapsulation at 67% and 73%, and sustained OVA release in SIF (96 h) at 65% and 64% respectively.
32240692	6	75	from	release	1380:1386	arg1	SIF					1391:1393	SIF	1391:1393	SIF (96 h)	1391:1400	Both showed highest OVA encapsulation at 67% and 73%, and sustained OVA release in SIF (96 h) at 65% and 64% respectively.
32240692	0	76	theme	Mobile	24:29	arg1	Composition					31:41	Mobile Composition	24:41	Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles	24:86	Surface Modification of Mobile Composition of Matter (MCM)-41 Type Silica Nanoparticles for Potential Oral Mucosa Vaccine Delivery.
32240692	1	77	theme	antigen	256:262	arg1	efficiency					272:281	antigen loading efficiency	256:281	antigen loading efficiency	256:281	Development of mobile composition of matter (MCM)-41 silica nanoparticles faces challenges, e.g. surface charge properties, antigen loading efficiency, protecting from enzymes and harsh GIT environment and effective release at target mucosal site.
32240692	4	78	dep	remained	1103:1110	arg1	SEM					1169:1171	SEM	1169:1171	SEM	1169:1171	Unmodified nanoparticles size of 146 nm increased to 175-321 nm after modification while modified particles remained intact for more than 3 h in SGF and 96 h in SIF (DLS and SEM).
32240692	4	78	dep	remained	1103:1110	arg1	DLS					1161:1163	DLS	1161:1163	DLS	1161:1163	Unmodified nanoparticles size of 146 nm increased to 175-321 nm after modification while modified particles remained intact for more than 3 h in SGF and 96 h in SIF (DLS and SEM).
32240692	2	79	theme	modified	447:454	arg1	nanoparticles					475:487	modified MCM-41 type silica nanoparticles	447:487	modified MCM-41 type silica nanoparticles	447:487	We report the production and characterization of polymer and amine modified MCM-41 type silica nanoparticles for oral antigen delivery using ovalbumin (OVA) as model antigen.
32240692	5	80	theme	oral	1286:1289	arg1	delivery					1298:1305	oral mucosa delivery	1286:1305	oral mucosa delivery	1286:1305	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	3	81	theme	simulated	887:895	arg1	SGF					912:914	SGF	912:914	SGF	912:914	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	81	theme	simulated	887:895	arg1	fluid					905:909	simulated gastric fluid	887:909	simulated gastric fluid (SGF)	887:915	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	81	theme	simulated	887:895	arg1	SIF					949:951	SIF	949:951	SIF	949:951	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	82	theme	scanning	636:643	arg1	calorimetry					645:655	differential scanning calorimetry	623:655	differential scanning calorimetry (DSC)	623:661	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	82	theme	scanning	636:643	arg1	scattering					605:614	dynamic light scattering	591:614	dynamic light scattering (DLS)	591:620	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	82	theme	scanning	636:643	arg1	DSC					658:660	DSC	658:660	DSC	658:660	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	5	83	theme	modified	1235:1242	arg1	glycol					1209:1214	polyethylene glycol	1196:1214	polyethylene glycol (PEG)	1196:1220	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	5	83	theme	modified	1235:1242	arg1	nanoparticles					1244:1256	chitosan modified nanoparticles	1226:1256	chitosan modified nanoparticles	1226:1256	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	5	83	theme	modified	1235:1242	arg1	candidates					1271:1280	potential candidates	1261:1280	potential candidates for oral mucosa delivery	1261:1305	Mucin binding proved polyethylene glycol (PEG) and chitosan modified nanoparticles as potential candidates for oral mucosa delivery.
32240692	3	84	theme	X-ray	664:668	arg1	XRD					683:685	XRD	683:685	XRD	683:685	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	84	theme	X-ray	664:668	arg1	diffraction					670:680	X-ray diffraction	664:680	X-ray diffraction (XRD)	664:686	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	84	theme	X-ray	664:668	arg1	scattering					605:614	dynamic light scattering	591:614	dynamic light scattering (DLS)	591:620	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	85	theme	Brunauer-Emmett-Teller	725:746	arg1	analysis					754:761	Brunauer-Emmett-Teller (BET) analysis	725:761	Brunauer-Emmett-Teller (BET) analysis	725:761	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
32240692	3	85	theme	Brunauer-Emmett-Teller	725:746	arg1	scattering					605:614	dynamic light scattering	591:614	dynamic light scattering (DLS)	591:620	Nanoparticles were characterized by dynamic light scattering (DLS), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, circular dichroism (CD), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), mucin binding, stability in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and in vitro OVA release in SGF and SIF.
33930685	5	0	theme	30 min	1108:1113	arg1	time					1100:1103	reaction time	1091:1103	reaction time of 30 min	1091:1113	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	0	theme	30 min	1108:1113	arg1	concentration					966:978	1 wt% zeolite-chitosan composite concentration	933:978	1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm	933:1085	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	0	theme	30 min	1108:1113	arg1	ratio					919:923	WFO molar ratio	909:923	WFO molar ratio of 8:1	909:930	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	4	1	theme	co	659:660	arg1	amount					670:675	co solvent amount	659:675	co solvent amount	659:675	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	4	1	theme	co	659:660	arg1	methanol					713:720	methanol	713:720	methanol	713:720	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	4	2	from	WFO	725:727	arg1	transesterification					745:763	electrolytic transesterification	732:763	electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite	732:887	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	1	3	theme	Fried	182:186	arg1	material					212:219	a starting material	201:219	a starting material	201:219	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	1	3	theme	Fried	182:186	arg1	WFO					193:195	WFO	193:195	WFO	193:195	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	1	3	theme	Fried	182:186	arg1	Oil					188:190	Waste Fried Oil	176:190	Waste Fried Oil (WFO)	176:196	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	7	4	theme	X-ray	1366:1370	arg1	XRD					1385:1387	XRD	1385:1387	XRD	1385:1387	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	7	4	theme	X-ray	1366:1370	arg1	Diffraction					1372:1382	X-ray Diffraction	1366:1382	X-ray Diffraction (XRD)	1366:1388	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	0	5	theme	biodiesel	97:105	arg1	production					107:116	biodiesel production	97:116	biodiesel production	97:116	Electrolytic transesterification of waste frying oil using Na+/zeolite-chitosan biocomposite for biodiesel production.
33930685	5	6	theme	stirrer	1063:1069	arg1	rate					1071:1074	stirrer rate	1063:1074	stirrer rate of 400 rpm	1063:1085	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	6	7	theme	fuel	1195:1198	arg1	properties					1200:1209	physical and biodiesel fuel properties	1172:1209	physical and biodiesel fuel properties	1172:1209	Characterization of physical and biodiesel fuel properties was performed using American Society for Testing and Materials (ASTM) methods.
33930685	8	8	theme	Gas	1669:1671	arg1	GC-MS					1707:1711	GC-MS	1707:1711	GC-MS	1707:1711	Finally, the physical properties of FAME produced under optimal conditions were studied using Gas Chromatography-Mass Spectrometry (GC-MS), FTIR, surface tension, and viscosity.
33930685	8	8	theme	Gas	1669:1671	arg1	Spectrometry					1693:1704	Gas Chromatography-Mass Spectrometry	1669:1704	Gas Chromatography-Mass Spectrometry (GC-MS)	1669:1712	Finally, the physical properties of FAME produced under optimal conditions were studied using Gas Chromatography-Mass Spectrometry (GC-MS), FTIR, surface tension, and viscosity.
33930685	7	9	dep	Fourier	1331:1337	arg1	Transform					1339:1347	Transform	1339:1347	Transform	1339:1347	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	5	10	theme	room	1042:1045	arg1	temperature					1047:1057	room temperature	1042:1057	room temperature	1042:1057	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	11	theme	96.5	1118:1121	arg1	%					1122:1122	%	1122:1122	%	1122:1122	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	6	12	theme	biodiesel	1185:1193	arg1	properties					1200:1209	physical and biodiesel fuel properties	1172:1209	physical and biodiesel fuel properties	1172:1209	Characterization of physical and biodiesel fuel properties was performed using American Society for Testing and Materials (ASTM) methods.
33930685	3	13	theme	nucleophilic	498:509	arg1	methoxide					511:519	nucleophilic methoxide	498:519	nucleophilic methoxide	498:519	When hydroxyl ions react with methanol, they produce a species of nucleophilic methoxide which is the main actor in converting WFO into FAME.
33930685	5	14	theme	molar	913:917	arg1	ratio					919:923	WFO molar ratio	909:923	WFO molar ratio of 8:1	909:930	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	1	15	theme	WFO	268:270	arg1	conversion					254:263	the conversion	250:263	the conversion of WFO to Fatty Acid Methyl Ester (FAME)	250:304	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	5	16	theme	whole	1024:1028	arg1	solution					1030:1037	the whole solution	1020:1037	the whole solution	1020:1037	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	4	17	theme	ratio	704:708	arg1	effects					615:621	the effects	611:621	the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite	611:887	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	3	18	theme	methoxide	511:519	arg1	species					487:493	a species	485:493	a species of nucleophilic methoxide which is the main actor in converting WFO into FAME	485:571	When hydroxyl ions react with methanol, they produce a species of nucleophilic methoxide which is the main actor in converting WFO into FAME.
33930685	3	18	theme	methoxide	511:519	arg1	actor					539:543	the main actor	530:543	the main actor in converting WFO into FAME	530:571	When hydroxyl ions react with methanol, they produce a species of nucleophilic methoxide which is the main actor in converting WFO into FAME.
33930685	7	19	theme	X-ray	1549:1553	arg1	EDX					1569:1571	EDX	1569:1571	EDX	1569:1571	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	7	19	theme	X-ray	1549:1553	arg1	spectrometry					1555:1566	Energy Dispersive X-ray spectrometry	1531:1566	Energy Dispersive X-ray spectrometry (EDX)	1531:1572	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	4	20	theme	speed	687:691	arg1	effects					615:621	the effects	611:621	the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite	611:887	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	4	21	theme	graphite	796:803	arg1	electrodes					805:814	graphite electrodes	796:814	graphite electrodes	796:814	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	3	22	theme	hydroxyl	437:444	arg1	ions					446:449	hydroxyl ions	437:449	hydroxyl ions	437:449	When hydroxyl ions react with methanol, they produce a species of nucleophilic methoxide which is the main actor in converting WFO into FAME.
33930685	5	23	theme	8:1	928:930	arg1	time					1100:1103	reaction time	1091:1103	reaction time of 30 min	1091:1113	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	23	theme	8:1	928:930	arg1	concentration					966:978	1 wt% zeolite-chitosan composite concentration	933:978	1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm	933:1085	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	23	theme	8:1	928:930	arg1	ratio					919:923	WFO molar ratio	909:923	WFO molar ratio of 8:1	909:930	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	1	24	from	use	327:329	arg1	waste					334:338	waste	334:338	waste	334:338	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	6	25	dep	Society	1240:1246	arg1	methods					1281:1287	methods	1281:1287	methods	1281:1287	Characterization of physical and biodiesel fuel properties was performed using American Society for Testing and Materials (ASTM) methods.
33930685	4	26	theme	methanol	713:720	arg1	amount					670:675	co solvent amount	659:675	co solvent amount	659:675	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	4	26	theme	methanol	713:720	arg1	ratio					704:708	molar ratio	698:708	molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite	698:887	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	4	26	theme	methanol	713:720	arg1	methanol					713:720	methanol	713:720	methanol	713:720	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	4	26	theme	methanol	713:720	arg1	concentration					644:656	catalyst concentration	635:656	catalyst concentration	635:656	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	4	26	theme	methanol	713:720	arg1	speed					687:691	rotation speed	678:691	rotation speed	678:691	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	4	26	theme	methanol	713:720	arg1	voltage					626:632	voltage	626:632	voltage	626:632	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	7	27	theme	Dispersive	1538:1547	arg1	EDX					1569:1571	EDX	1569:1571	EDX	1569:1571	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	7	27	theme	Dispersive	1538:1547	arg1	spectrometry					1555:1566	Energy Dispersive X-ray spectrometry	1531:1566	Energy Dispersive X-ray spectrometry (EDX)	1531:1572	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	4	28	dep	heterogeneous	837:849	arg1	catalytic					852:860	catalytic	852:860	catalytic	852:860	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	5	29	theme	solution	1030:1037	arg1	H2O					1013:1015	2 wt% H2O	1007:1015	2 wt% H2O of the whole solution	1007:1037	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	2	30	theme	hydroxyl	358:365	arg1	ions					367:370	hydroxyl ions	358:370	hydroxyl ions	358:370	In electrolysis, hydroxyl ions are generated from water in close proximity to the cathode.
33930685	0	31	theme	Electrolytic	0:11	arg1	transesterification					13:31	Electrolytic transesterification	0:31	Electrolytic transesterification of waste frying oil using Na+/zeolite-chitosan biocomposite for biodiesel production.	0:117	Electrolytic transesterification of waste frying oil using Na+/zeolite-chitosan biocomposite for biodiesel production.
33930685	1	32	theme	Fatty	275:279	arg1	FAME					300:303	FAME	300:303	FAME	300:303	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	1	32	theme	Fatty	275:279	arg1	Ester					293:297	Fatty Acid Methyl Ester	275:297	Fatty Acid Methyl Ester (FAME)	275:304	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	7	33	theme	Electron	1404:1411	arg1	Microscopy					1413:1422	Transmission Electron Microscopy	1391:1422	Transmission Electron Microscopy(TEM)	1391:1427	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	7	33	theme	Electron	1404:1411	arg1	TEM					1424:1426	TEM	1424:1426	TEM	1424:1426	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	3	34	theme	main	534:537	arg1	actor					539:543	the main actor	530:543	the main actor in converting WFO into FAME	530:571	When hydroxyl ions react with methanol, they produce a species of nucleophilic methoxide which is the main actor in converting WFO into FAME.
33930685	3	34	theme	main	534:537	arg1	species					487:493	a species	485:493	a species of nucleophilic methoxide which is the main actor in converting WFO into FAME	485:571	When hydroxyl ions react with methanol, they produce a species of nucleophilic methoxide which is the main actor in converting WFO into FAME.
33930685	5	35	from	40 V	983:986	arg1	time					1100:1103	reaction time	1091:1103	reaction time of 30 min	1091:1113	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	35	from	40 V	983:986	arg1	concentration					966:978	1 wt% zeolite-chitosan composite concentration	933:978	1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm	933:1085	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	35	from	40 V	983:986	arg1	ratio					919:923	WFO molar ratio	909:923	WFO molar ratio of 8:1	909:930	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	35	from	40 V	983:986	arg1	presence					995:1002	the presence	991:1002	the presence of 2 wt% H2O of the whole solution	991:1037	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	4	36	theme	voltage	626:632	arg1	effects					615:621	the effects	611:621	the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite	611:887	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	0	37	theme	waste	36:40	arg1	oil					49:51	waste frying oil	36:51	waste frying oil	36:51	Electrolytic transesterification of waste frying oil using Na+/zeolite-chitosan biocomposite for biodiesel production.
33930685	1	38	theme	Acid	281:284	arg1	FAME					300:303	FAME	300:303	FAME	300:303	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	1	38	theme	Acid	281:284	arg1	Ester					293:297	Fatty Acid Methyl Ester	275:297	Fatty Acid Methyl Ester (FAME)	275:304	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	7	39	theme	Electron	1501:1508	arg1	SEM					1522:1524	SEM	1522:1524	SEM	1522:1524	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	7	39	theme	Electron	1501:1508	arg1	Microscopy					1510:1519	Scanning Electron Microscopy	1492:1519	Scanning Electron Microscopy (SEM)	1492:1525	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	8	40	theme	Chromatography-Mass	1673:1691	arg1	GC-MS					1707:1711	GC-MS	1707:1711	GC-MS	1707:1711	Finally, the physical properties of FAME produced under optimal conditions were studied using Gas Chromatography-Mass Spectrometry (GC-MS), FTIR, surface tension, and viscosity.
33930685	8	40	theme	Chromatography-Mass	1673:1691	arg1	Spectrometry					1693:1704	Gas Chromatography-Mass Spectrometry	1669:1704	Gas Chromatography-Mass Spectrometry (GC-MS)	1669:1712	Finally, the physical properties of FAME produced under optimal conditions were studied using Gas Chromatography-Mass Spectrometry (GC-MS), FTIR, surface tension, and viscosity.
33930685	4	41	theme	molar	698:702	arg1	ratio					704:708	molar ratio	698:708	molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite	698:887	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	7	42	theme	Energy	1531:1536	arg1	EDX					1569:1571	EDX	1569:1571	EDX	1569:1571	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	7	42	theme	Energy	1531:1536	arg1	spectrometry					1555:1566	Energy Dispersive X-ray spectrometry	1531:1566	Energy Dispersive X-ray spectrometry (EDX)	1531:1572	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	2	43	theme	close	400:404	arg1	proximity					406:414	close proximity	400:414	close proximity to the cathode	400:429	In electrolysis, hydroxyl ions are generated from water in close proximity to the cathode.
33930685	1	44	theme	Methyl	286:291	arg1	FAME					300:303	FAME	300:303	FAME	300:303	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	1	44	theme	Methyl	286:291	arg1	Ester					293:297	Fatty Acid Methyl Ester	275:297	Fatty Acid Methyl Ester (FAME)	275:304	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	4	45	theme	composite	879:887	arg1	presence					823:830	the presence	819:830	the presence of a heterogeneous, catalytic zeolite-chitosan composite	819:887	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	5	46	theme	%	1011:1011	arg1	H2O					1013:1015	2 wt% H2O	1007:1015	2 wt% H2O of the whole solution	1007:1037	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	1	47	theme	economic	129:136	arg1	advantages					156:165	the economic and environmental advantages	125:165	the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material	125:219	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	1	48	theme	starting	203:210	arg1	material					212:219	a starting material	201:219	a starting material	201:219	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	1	48	theme	starting	203:210	arg1	Oil					188:190	Waste Fried Oil	176:190	Waste Fried Oil (WFO)	176:196	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	0	49	theme	oil	49:51	arg1	transesterification					13:31	Electrolytic transesterification	0:31	Electrolytic transesterification of waste frying oil using Na+/zeolite-chitosan biocomposite for biodiesel production.	0:117	Electrolytic transesterification of waste frying oil using Na+/zeolite-chitosan biocomposite for biodiesel production.
33930685	4	50	theme	solvent	662:668	arg1	amount					670:675	co solvent amount	659:675	co solvent amount	659:675	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	4	50	theme	solvent	662:668	arg1	methanol					713:720	methanol	713:720	methanol	713:720	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	8	51	theme	surface	1721:1727	arg1	tension					1729:1735	surface tension	1721:1735	surface tension	1721:1735	Finally, the physical properties of FAME produced under optimal conditions were studied using Gas Chromatography-Mass Spectrometry (GC-MS), FTIR, surface tension, and viscosity.
33930685	5	52	theme	H2O	1013:1015	arg1	presence					995:1002	the presence	991:1002	the presence of 2 wt% H2O of the whole solution	991:1037	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	6	53	theme	properties	1200:1209	arg1	Characterization					1152:1167	Characterization	1152:1167	Characterization of physical and biodiesel fuel properties	1152:1209	Characterization of physical and biodiesel fuel properties was performed using American Society for Testing and Materials (ASTM) methods.
33930685	8	54	theme	physical	1588:1595	arg1	properties					1597:1606	the physical properties	1584:1606	the physical properties of FAME produced under optimal conditions	1584:1648	Finally, the physical properties of FAME produced under optimal conditions were studied using Gas Chromatography-Mass Spectrometry (GC-MS), FTIR, surface tension, and viscosity.
33930685	0	55	theme	frying	42:47	arg1	oil					49:51	waste frying oil	36:51	waste frying oil	36:51	Electrolytic transesterification of waste frying oil using Na+/zeolite-chitosan biocomposite for biodiesel production.
33930685	5	56	from	rate	1071:1074	arg1	time					1100:1103	reaction time	1091:1103	reaction time of 30 min	1091:1113	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	56	from	rate	1071:1074	arg1	concentration					966:978	1 wt% zeolite-chitosan composite concentration	933:978	1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm	933:1085	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	56	from	rate	1071:1074	arg1	ratio					919:923	WFO molar ratio	909:923	WFO molar ratio of 8:1	909:930	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	8	57	theme	FAME	1611:1614	arg1	properties					1597:1606	the physical properties	1584:1606	the physical properties of FAME produced under optimal conditions	1584:1648	Finally, the physical properties of FAME produced under optimal conditions were studied using Gas Chromatography-Mass Spectrometry (GC-MS), FTIR, surface tension, and viscosity.
33930685	5	58	theme	reaction	1091:1098	arg1	time					1100:1103	reaction time	1091:1103	reaction time of 30 min	1091:1113	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	0	59	theme	Na+/zeolite-chitosan	59:78	arg1	biocomposite					80:91	Na+/zeolite-chitosan biocomposite	59:91	Na+/zeolite-chitosan biocomposite for biodiesel production	59:116	Electrolytic transesterification of waste frying oil using Na+/zeolite-chitosan biocomposite for biodiesel production.
33930685	5	60	theme	400 rpm	1079:1085	arg1	temperature					1047:1057	room temperature	1042:1057	room temperature	1042:1057	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	60	theme	400 rpm	1079:1085	arg1	rate					1071:1074	stirrer rate	1063:1074	stirrer rate of 400 rpm	1063:1085	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	7	61	dep	Infrared	1349:1356	arg1	FTIR					1359:1362	FTIR	1359:1362	FTIR	1359:1362	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	4	62	theme	amount	670:675	arg1	effects					615:621	the effects	611:621	the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite	611:887	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	5	63	from	temperature	1047:1057	arg1	time					1100:1103	reaction time	1091:1103	reaction time of 30 min	1091:1113	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	63	from	temperature	1047:1057	arg1	concentration					966:978	1 wt% zeolite-chitosan composite concentration	933:978	1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm	933:1085	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	63	from	temperature	1047:1057	arg1	ratio					919:923	WFO molar ratio	909:923	WFO molar ratio of 8:1	909:930	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	4	64	theme	heterogeneous	837:849	arg1	composite					879:887	a heterogeneous, catalytic zeolite-chitosan composite	835:887	a heterogeneous, catalytic zeolite-chitosan composite	835:887	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	7	65	theme	Scanning	1492:1499	arg1	SEM					1522:1524	SEM	1522:1524	SEM	1522:1524	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	7	65	theme	Scanning	1492:1499	arg1	Microscopy					1510:1519	Scanning Electron Microscopy	1492:1519	Scanning Electron Microscopy (SEM)	1492:1525	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	1	66	theme	environmental	142:154	arg1	advantages					156:165	the economic and environmental advantages	125:165	the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material	125:219	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	5	67	theme	composite	956:964	arg1	concentration					966:978	1 wt% zeolite-chitosan composite concentration	933:978	1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm	933:1085	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	4	68	theme	zeolite-chitosan	862:877	arg1	composite					879:887	a heterogeneous, catalytic zeolite-chitosan composite	835:887	a heterogeneous, catalytic zeolite-chitosan composite	835:887	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	7	69	theme	Transmission	1391:1402	arg1	Microscopy					1413:1422	Transmission Electron Microscopy	1391:1422	Transmission Electron Microscopy(TEM)	1391:1427	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	7	69	theme	Transmission	1391:1402	arg1	TEM					1424:1426	TEM	1424:1426	TEM	1424:1426	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	5	70	theme	1 wt	933:936	arg1	concentration					966:978	1 wt% zeolite-chitosan composite concentration	933:978	1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm	933:1085	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	4	71	theme	rotation	678:685	arg1	speed					687:691	rotation speed	678:691	rotation speed	678:691	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	5	72	theme	WFO	909:911	arg1	ratio					919:923	WFO molar ratio	909:923	WFO molar ratio of 8:1	909:930	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	7	73	theme	Thermogravimetric	1459:1475	arg1	TG					1487:1488	TG	1487:1488	TG	1487:1488	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	7	73	theme	Thermogravimetric	1459:1475	arg1	analysis					1477:1484	Thermogravimetric analysis	1459:1484	Thermogravimetric analysis (TG)	1459:1489	The biocomposite was characterized using Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Transmission Electron Microscopy(TEM), Brunauer Emmett Teller(BET), Thermogravimetric analysis (TG), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray spectrometry (EDX).
33930685	6	74	theme	physical	1172:1179	arg1	properties					1200:1209	physical and biodiesel fuel properties	1172:1209	physical and biodiesel fuel properties	1172:1209	Characterization of physical and biodiesel fuel properties was performed using American Society for Testing and Materials (ASTM) methods.
33930685	5	75	theme	%	937:937	arg1	concentration					966:978	1 wt% zeolite-chitosan composite concentration	933:978	1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm	933:1085	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	4	76	theme	catalyst	635:642	arg1	concentration					644:656	catalyst concentration	635:656	catalyst concentration	635:656	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	5	77	theme	FAME	1133:1136	arg1	yield					1124:1128	a 96.5% yield	1116:1128	a 96.5% yield of FAME	1116:1136	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	78	theme	2 wt	1007:1010	arg1	H2O					1013:1015	2 wt% H2O	1007:1015	2 wt% H2O of the whole solution	1007:1037	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	5	79	theme	zeolite-chitosan	939:954	arg1	concentration					966:978	1 wt% zeolite-chitosan composite concentration	933:978	1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm	933:1085	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	8	80	theme	optimal	1631:1637	arg1	conditions					1639:1648	optimal conditions	1631:1648	optimal conditions	1631:1648	Finally, the physical properties of FAME produced under optimal conditions were studied using Gas Chromatography-Mass Spectrometry (GC-MS), FTIR, surface tension, and viscosity.
33930685	4	81	theme	concentration	644:656	arg1	effects					615:621	the effects	611:621	the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite	611:887	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	5	82	theme	%	1122:1122	arg1	yield					1124:1128	a 96.5% yield	1116:1128	a 96.5% yield of FAME	1116:1136	With an alcohol to WFO molar ratio of 8:1, 1 wt% zeolite-chitosan composite concentration at 40 V in the presence of 2 wt% H2O of the whole solution at room temperature and stirrer rate of 400 rpm and reaction time of 30 min, a 96.5% yield of FAME was achieved.
33930685	4	83	theme	electrolytic	732:743	arg1	transesterification					745:763	electrolytic transesterification	732:763	electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite	732:887	This study specifically investigates the effects of voltage, catalyst concentration, co solvent amount, rotation speed, and molar ratio of methanol to WFO in electrolytic transesterification converting WFO into FAME using graphite electrodes in the presence of a heterogeneous, catalytic zeolite-chitosan composite.
33930685	1	84	theme	Waste	176:180	arg1	material					212:219	a starting material	201:219	a starting material	201:219	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	1	84	theme	Waste	176:180	arg1	WFO					193:195	WFO	193:195	WFO	193:195	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
33930685	1	84	theme	Waste	176:180	arg1	Oil					188:190	Waste Fried Oil	176:190	Waste Fried Oil (WFO)	176:196	Given the economic and environmental advantages of using Waste Fried Oil (WFO) as a starting material, this investigation explores the conversion of WFO to Fatty Acid Methyl Ester (FAME) via electrolysis for use in waste.
34565460	4	0	theme	training	872:879	arg1	weeks					845:849	eight weeks	839:849	eight weeks of swimming physical training	839:879	This study found that eight weeks of swimming physical training protected renal function and restored normal glomerular filtration rate (GFR) values.
34565460	1	1	theme	sucrose	287:293	arg1	diet					295:298	a high sucrose diet	280:298	a high sucrose diet (SUD)	280:304	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	1	1	theme	sucrose	287:293	arg1	SUD					301:303	SUD	301:303	SUD	301:303	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	2	2	theme	number	502:507	arg1	cells					515:519	number renal cells	502:519	number renal cells	502:519	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	4	3	theme	rate	948:951	arg1	values					959:964	normal glomerular filtration rate (GFR) values	919:964	normal glomerular filtration rate (GFR) values	919:964	This study found that eight weeks of swimming physical training protected renal function and restored normal glomerular filtration rate (GFR) values.
34565460	1	4	theme	renal	205:209	arg1	system					211:216	the renal system	201:216	the renal system	201:216	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	0	5	theme	body	73:76	arg1	composition					78:88	body composition	73:88	body composition of rats fed a high sucrose diet	73:120	Aerobic exercise training prevents impairment in renal parameters and in body composition of rats fed a high sucrose diet.
34565460	5	6	theme	onset	1023:1027	arg1	prevention					1005:1014	prevention	1005:1014	prevention of the onset of a renal inflammatory process	1005:1059	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	5	7	dep	parameters	1169:1178	arg1	LI					1186:1187	LI	1186:1187	LI	1186:1187	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	5	7	dep	parameters	1169:1178	arg1	parameters					1169:1178	the body composition parameters	1148:1178	the body composition parameters (BAI, LI, and RAT weight)	1148:1204	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	5	7	dep	parameters	1169:1178	arg1	BAI					1181:1183	BAI	1181:1183	BAI	1181:1183	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	5	7	dep	parameters	1169:1178	arg1	weight					1198:1203	RAT weight	1194:1203	RAT weight	1194:1203	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	1	8	theme	system	211:216	arg1	parameters					239:248	the renal system and body composition parameters	201:248	the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks	201:320	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	0	9	theme	rats	93:96	arg1	composition					78:88	body composition	73:88	body composition of rats fed a high sucrose diet	73:120	Aerobic exercise training prevents impairment in renal parameters and in body composition of rats fed a high sucrose diet.
34565460	4	10	theme	physical	863:870	arg1	training					872:879	swimming physical training	854:879	swimming physical training	854:879	This study found that eight weeks of swimming physical training protected renal function and restored normal glomerular filtration rate (GFR) values.
34565460	2	11	theme	plasma	480:485	arg1	creatinine					487:496	plasma creatinine	480:496	plasma creatinine	480:496	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	2	12	theme	urinary	539:545	arg1	volume					547:552	urinary volume	539:552	urinary volume	539:552	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	3	13	theme	urinary	790:796	arg1	excretion					806:814	urinary protein excretion	790:814	urinary protein excretion	790:814	The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion.
34565460	1	14	theme	body	222:225	arg1	composition					227:237	body composition	222:237	body composition	222:237	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	3	15	theme	increased	636:644	arg1	BAI					650:652	BAI	650:652	BAI	650:652	The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion.
34565460	2	16	theme	tissue	459:464	arg1	weight					472:477	retroperitoneal adipose tissue (RAT) weight	435:477	retroperitoneal adipose tissue (RAT) weight	435:477	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	2	17	theme	physical	352:359	arg1	performance					361:371	the physical performance	348:371	the physical performance	348:371	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	3	18	theme	protein	798:804	arg1	excretion					806:814	urinary protein excretion	790:814	urinary protein excretion	790:814	The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion.
34565460	2	19	theme	adiposity	393:401	arg1	index					403:407	the body adiposity index	384:407	the body adiposity index (BAI)	384:413	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	2	19	theme	adiposity	393:401	arg1	BAI					410:412	BAI	410:412	BAI	410:412	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	4	20	theme	normal	919:924	arg1	values					959:964	normal glomerular filtration rate (GFR) values	919:964	normal glomerular filtration rate (GFR) values	919:964	This study found that eight weeks of swimming physical training protected renal function and restored normal glomerular filtration rate (GFR) values.
34565460	5	21	theme	composition	1157:1167	arg1	LI					1186:1187	LI	1186:1187	LI	1186:1187	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	5	21	theme	composition	1157:1167	arg1	weight					1198:1203	RAT weight	1194:1203	RAT weight	1194:1203	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	5	21	theme	composition	1157:1167	arg1	BAI					1181:1183	BAI	1181:1183	BAI	1181:1183	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	5	21	theme	composition	1157:1167	arg1	parameters					1169:1178	the body composition parameters	1148:1178	the body composition parameters (BAI, LI, and RAT weight)	1148:1204	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	0	22	theme	exercise	8:15	arg1	training					17:24	Aerobic exercise training	0:24	Aerobic exercise training	0:24	Aerobic exercise training prevents impairment in renal parameters and in body composition of rats fed a high sucrose diet.
34565460	0	23	from	impairment	35:44	arg1	composition					78:88	body composition	73:88	body composition of rats fed a high sucrose diet	73:120	Aerobic exercise training prevents impairment in renal parameters and in body composition of rats fed a high sucrose diet.
34565460	0	23	from	impairment	35:44	arg1	parameters					55:64	renal parameters	49:64	renal parameters	49:64	Aerobic exercise training prevents impairment in renal parameters and in body composition of rats fed a high sucrose diet.
34565460	0	24	theme	Aerobic	0:6	arg1	training					17:24	Aerobic exercise training	0:24	Aerobic exercise training	0:24	Aerobic exercise training prevents impairment in renal parameters and in body composition of rats fed a high sucrose diet.
34565460	1	25	theme	composition	227:237	arg1	parameters					239:248	the renal system and body composition parameters	201:248	the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks	201:320	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	1	26	from	parameters	239:248	arg1	animals					259:265	young animals	253:265	young animals treated with a high sucrose diet (SUD) during 12 weeks	253:320	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	2	27	theme	creatinine	566:575	arg1	excretion					577:585	urinary creatinine excretion	558:585	urinary creatinine excretion	558:585	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	4	28	theme	filtration	937:946	arg1	GFR					954:956	GFR	954:956	GFR	954:956	This study found that eight weeks of swimming physical training protected renal function and restored normal glomerular filtration rate (GFR) values.
34565460	4	28	theme	filtration	937:946	arg1	rate					948:951	glomerular filtration rate	926:951	normal glomerular filtration rate (GFR) values	919:964	This study found that eight weeks of swimming physical training protected renal function and restored normal glomerular filtration rate (GFR) values.
34565460	0	29	theme	sucrose	109:115	arg1	diet					117:120	a high sucrose diet	102:120	a high sucrose diet	102:120	Aerobic exercise training prevents impairment in renal parameters and in body composition of rats fed a high sucrose diet.
34565460	2	30	theme	urinary	558:564	arg1	excretion					577:585	urinary creatinine excretion	558:585	urinary creatinine excretion	558:585	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	1	31	dep	OBJECTIVE	123:131	arg1	aimed					144:148	aimed	144:148	aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks	144:320	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	3	32	dep	promoting	768:776	arg1	addition					756:763	addition	756:763	addition	756:763	The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion.
34565460	4	33	theme	glomerular	926:935	arg1	GFR					954:956	GFR	954:956	GFR	954:956	This study found that eight weeks of swimming physical training protected renal function and restored normal glomerular filtration rate (GFR) values.
34565460	4	33	theme	glomerular	926:935	arg1	rate					948:951	glomerular filtration rate	926:951	normal glomerular filtration rate (GFR) values	919:964	This study found that eight weeks of swimming physical training protected renal function and restored normal glomerular filtration rate (GFR) values.
34565460	2	34	dep	weight	472:477	arg1	nuclei					521:526	nuclei	521:526	nuclei	521:526	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	0	35	theme	high	104:107	arg1	diet					117:120	a high sucrose diet	102:120	a high sucrose diet	102:120	Aerobic exercise training prevents impairment in renal parameters and in body composition of rats fed a high sucrose diet.
34565460	1	36	theme	swimming	176:183	arg1	T					195:195	T	195:195	T	195:195	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	1	36	theme	swimming	176:183	arg1	training					185:192	swimming training	176:192	swimming training (T)	176:196	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	4	37	theme	renal	891:895	arg1	function					897:904	renal function	891:904	renal function	891:904	This study found that eight weeks of swimming physical training protected renal function and restored normal glomerular filtration rate (GFR) values.
34565460	1	38	theme	young	253:257	arg1	animals					259:265	young animals	253:265	young animals treated with a high sucrose diet (SUD) during 12 weeks	253:320	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	2	39	theme	adipose	451:457	arg1	weight					472:477	retroperitoneal adipose tissue (RAT) weight	435:477	retroperitoneal adipose tissue (RAT) weight	435:477	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	5	40	theme	development	1098:1108	arg1	risk					1090:1093	the risk	1086:1093	the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight)	1086:1204	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	1	41	theme	training	185:192	arg1	effect					166:171	the effect	162:171	the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks	162:320	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	3	42	theme	creatinine	702:711	arg1	clearance					713:721	creatinine clearance	702:721	creatinine clearance	702:721	The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion.
34565460	2	43	theme	retroperitoneal	435:449	arg1	weight					472:477	retroperitoneal adipose tissue (RAT) weight	435:477	retroperitoneal adipose tissue (RAT) weight	435:477	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	5	44	theme	Swimming	967:974	arg1	training					976:983	Swimming training	967:983	Swimming training	967:983	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	2	45	dep	impaired	339:346	arg1	decreased					529:537	decreased	529:537	decreased urinary volume and urinary creatinine excretion besides creatinine clearance	529:614	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	2	45	dep	impaired	339:346	arg1	increased					374:382	increased	374:382	increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei	374:526	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	5	46	theme	process	1053:1059	arg1	onset					1023:1027	the onset	1019:1027	the onset of a renal inflammatory process	1019:1059	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	5	47	theme	renal	1034:1038	arg1	process					1053:1059	a renal inflammatory process	1032:1059	a renal inflammatory process	1032:1059	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	3	48	dep	creatinine	690:699	arg1	cells					740:744	renal cells	734:744	renal cells	734:744	The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion.
34565460	0	49	theme	renal	49:53	arg1	parameters					55:64	renal parameters	49:64	renal parameters	49:64	Aerobic exercise training prevents impairment in renal parameters and in body composition of rats fed a high sucrose diet.
34565460	5	50	theme	inflammatory	1040:1051	arg1	process					1053:1059	a renal inflammatory process	1032:1059	a renal inflammatory process	1032:1059	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	5	51	from	decrease	1074:1081	arg1	risk					1090:1093	the risk	1086:1093	the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight)	1086:1204	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	3	52	dep	BAI	650:652	arg1	the					646:648	the	646:648	the	646:648	The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion.
34565460	3	52	dep	BAI	650:652	arg1	nuclei					746:751	nuclei	746:751	nuclei	746:751	The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion.
34565460	5	53	theme	body	1152:1155	arg1	LI					1186:1187	LI	1186:1187	LI	1186:1187	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	5	53	theme	body	1152:1155	arg1	weight					1198:1203	RAT weight	1194:1203	RAT weight	1194:1203	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	5	53	theme	body	1152:1155	arg1	BAI					1181:1183	BAI	1181:1183	BAI	1181:1183	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	5	53	theme	body	1152:1155	arg1	parameters					1169:1178	the body composition parameters	1148:1178	the body composition parameters (BAI, LI, and RAT weight)	1148:1204	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	3	54	theme	RAT	659:661	arg1	weight					663:668	RAT weight	659:668	RAT weight	659:668	The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion.
34565460	3	55	from	decrease	778:785	arg1	excretion					806:814	urinary protein excretion	790:814	urinary protein excretion	790:814	The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion.
34565460	2	56	dep	RESULTS	323:329	arg1	impaired					339:346	impaired	339:346	impaired the physical performance	339:371	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	2	57	theme	creatinine	595:604	arg1	clearance					606:614	creatinine clearance	595:614	creatinine clearance	595:614	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	2	58	theme	renal	509:513	arg1	cells					515:519	number renal cells	502:519	number renal cells	502:519	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	3	59	theme	urinary	682:688	arg1	creatinine					690:699	urinary creatinine	682:699	urinary creatinine	682:699	The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion.
34565460	2	60	theme	RAT	467:469	arg1	weight					472:477	retroperitoneal adipose tissue (RAT) weight	435:477	retroperitoneal adipose tissue (RAT) weight	435:477	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	5	61	theme	RAT	1194:1196	arg1	parameters					1169:1178	the body composition parameters	1148:1178	the body composition parameters (BAI, LI, and RAT weight)	1148:1204	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	5	61	theme	RAT	1194:1196	arg1	weight					1198:1203	RAT weight	1194:1203	RAT weight	1194:1203	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	4	62	theme	swimming	854:861	arg1	training					872:879	swimming physical training	854:879	swimming physical training	854:879	This study found that eight weeks of swimming physical training protected renal function and restored normal glomerular filtration rate (GFR) values.
34565460	1	63	from	effect	166:171	arg1	parameters					239:248	the renal system and body composition parameters	201:248	the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks	201:320	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	3	64	theme	renal	734:738	arg1	cells					740:744	renal cells	734:744	renal cells	734:744	The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion.
34565460	5	65	theme	obesity	1113:1119	arg1	development					1098:1108	development	1098:1108	development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight)	1098:1204	Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).
34565460	2	66	theme	Lee	416:418	arg1	LI					427:428	LI	427:428	LI	427:428	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	2	66	theme	Lee	416:418	arg1	index					420:424	Lee index	416:424	Lee index (LI)	416:429	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	1	67	theme	high	282:285	arg1	diet					295:298	a high sucrose diet	280:298	a high sucrose diet (SUD)	280:304	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	1	67	theme	high	282:285	arg1	SUD					301:303	SUD	301:303	SUD	301:303	OBJECTIVE This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.
34565460	2	68	theme	body	388:391	arg1	index					403:407	the body adiposity index	384:407	the body adiposity index (BAI)	384:413	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
34565460	2	68	theme	body	388:391	arg1	BAI					410:412	BAI	410:412	BAI	410:412	RESULTS The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.
32709331	8	0	dep	gain	1446:1449	arg1	achievable					1451:1460	achievable	1451:1460	achievable	1451:1460	The gain achievable by using the proposed sequence was then evaluated using 15 enantiomer pairs with focus on resolution, enantiomer elution order and chemoselectivity.
32709331	7	1	from	application	1289:1299	arg1	respects					1310:1317	these respects	1304:1317	these respects	1304:1317	The solvent mixtures that were eligible for practical application in these respects were used to construct a screening sequence, including identical compositions combined with different column pretreatment.
32709331	1	2	theme	selection	253:261	arg1	strategies					263:272	chiral HPLC method selection strategies	234:272	chiral HPLC method selection strategies	234:272	Polysaccharide-based chiral stationary phases (CSPs) are outstandingly suitable to play a key role in chiral HPLC method selection strategies, since they provide high success rates.
32709331	3	3	theme	amylose	651:657	arg1	selector					636:643	a widely used chiral selector	615:643	a widely used chiral selector (CS)	615:648	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	3	3	theme	amylose	651:657	arg1	3,5-dimethylphenylcarbamate					664:690	3,5-dimethylphenylcarbamate	664:690	3,5-dimethylphenylcarbamate	664:690	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	3	3	theme	amylose	651:657	arg1	tris					659:662	amylose tris	651:662	amylose tris(3,5-dimethylphenylcarbamate)	651:691	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	8	4	theme	proposed	1475:1482	arg1	sequence					1484:1491	the proposed sequence	1471:1491	the proposed sequence	1471:1491	The gain achievable by using the proposed sequence was then evaluated using 15 enantiomer pairs with focus on resolution, enantiomer elution order and chemoselectivity.
32709331	3	5	theme	chiral	629:634	arg1	CS					646:647	CS	646:647	CS	646:647	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	3	5	theme	chiral	629:634	arg1	selector					636:643	a widely used chiral selector	615:643	a widely used chiral selector (CS)	615:648	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	3	5	theme	chiral	629:634	arg1	tris					659:662	amylose tris	651:662	amylose tris(3,5-dimethylphenylcarbamate)	651:691	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	0	6	theme	polar	112:116	arg1	mode					126:129	polar organic mode	112:129	polar organic mode	112:129	Utilization of the hysteresis phenomenon for chiral high-performance liquid chromatographic method selection in polar organic mode.
32709331	7	7	used	used	1324:1327	arg2	eligible					1266:1273	eligible	1266:1273	eligible	1266:1273	The solvent mixtures that were eligible for practical application in these respects were used to construct a screening sequence, including identical compositions combined with different column pretreatment.
32709331	7	7	used	used	1324:1327	arg2	mixtures					1247:1254	The solvent mixtures	1235:1254	The solvent mixtures that were eligible for practical application in these respects	1235:1317	The solvent mixtures that were eligible for practical application in these respects were used to construct a screening sequence, including identical compositions combined with different column pretreatment.
32709331	4	8	theme	distinct	836:843	arg1	states					845:850	distinct states	836:850	distinct states of the chiral selector	836:873	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	3	9	dep	potential	466:474	arg1	extend					479:484	extend	479:484	to extend this versatility further	476:509	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	8	10	with	pairs	1532:1536	arg1	focus					1543:1547	focus	1543:1547	focus on resolution, enantiomer elution order and chemoselectivity	1543:1608	The gain achievable by using the proposed sequence was then evaluated using 15 enantiomer pairs with focus on resolution, enantiomer elution order and chemoselectivity.
32709331	6	11	theme	observed	1214:1221	arg1	retentions					1223:1232	the observed retentions	1210:1232	the observed retentions	1210:1232	Eluent mixtures consisting of 2-propanol and either methanol or ethanol were scrutinized in terms of stability and robustness of the observed retentions.
32709331	4	12	theme	hindered	698:705	arg1	transitions					707:717	The hindered transitions	694:717	The hindered transitions of its structure, which are behind the history dependence of its separation ability,	694:802	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	4	12	theme	hindered	698:705	arg1	tool					819:822	a tool	817:822	a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space	817:923	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	4	13	theme	selectivity	907:917	arg1	space					919:923	an extended selectivity space	895:923	an extended selectivity space	895:923	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	7	14	theme	identical	1374:1382	arg1	compositions					1384:1395	identical compositions	1374:1395	identical compositions combined with different column pretreatment	1374:1439	The solvent mixtures that were eligible for practical application in these respects were used to construct a screening sequence, including identical compositions combined with different column pretreatment.
32709331	2	15	theme	order	383:387	arg1	structures					389:398	higher order structures	376:398	higher order structures	376:398	One reason for this ability is that they adopt a diversity of higher order structures in various eluents, resulting in versatile chiral environments.
32709331	0	16	theme	organic	118:124	arg1	mode					126:129	polar organic mode	112:129	polar organic mode	112:129	Utilization of the hysteresis phenomenon for chiral high-performance liquid chromatographic method selection in polar organic mode.
32709331	7	17	theme	different	1411:1419	arg1	pretreatment					1428:1439	different column pretreatment	1411:1439	different column pretreatment	1411:1439	The solvent mixtures that were eligible for practical application in these respects were used to construct a screening sequence, including identical compositions combined with different column pretreatment.
32709331	8	18	theme	enantiomer	1564:1573	arg1	order					1583:1587	enantiomer elution order	1564:1587	enantiomer elution order	1564:1587	The gain achievable by using the proposed sequence was then evaluated using 15 enantiomer pairs with focus on resolution, enantiomer elution order and chemoselectivity.
32709331	2	19	theme	higher	376:381	arg1	structures					389:398	higher order structures	376:398	higher order structures	376:398	One reason for this ability is that they adopt a diversity of higher order structures in various eluents, resulting in versatile chiral environments.
32709331	2	20	theme	versatile	433:441	arg1	environments					450:461	versatile chiral environments	433:461	versatile chiral environments	433:461	One reason for this ability is that they adopt a diversity of higher order structures in various eluents, resulting in versatile chiral environments.
32709331	7	21	theme	column	1421:1426	arg1	pretreatment					1428:1439	different column pretreatment	1411:1439	different column pretreatment	1411:1439	The solvent mixtures that were eligible for practical application in these respects were used to construct a screening sequence, including identical compositions combined with different column pretreatment.
32709331	6	22	theme	robustness	1196:1205	arg1	terms					1173:1177	terms	1173:1177	terms of stability and robustness of the observed retentions	1173:1232	Eluent mixtures consisting of 2-propanol and either methanol or ethanol were scrutinized in terms of stability and robustness of the observed retentions.
32709331	8	23	theme	enantiomer	1521:1530	arg1	pairs					1532:1536	15 enantiomer pairs	1518:1536	15 enantiomer pairs with focus on resolution, enantiomer elution order and chemoselectivity	1518:1608	The gain achievable by using the proposed sequence was then evaluated using 15 enantiomer pairs with focus on resolution, enantiomer elution order and chemoselectivity.
32709331	8	24	from	focus	1543:1547	arg1	order					1583:1587	enantiomer elution order	1564:1587	enantiomer elution order	1564:1587	The gain achievable by using the proposed sequence was then evaluated using 15 enantiomer pairs with focus on resolution, enantiomer elution order and chemoselectivity.
32709331	8	24	from	focus	1543:1547	arg1	resolution					1552:1561	resolution	1552:1561	resolution	1552:1561	The gain achievable by using the proposed sequence was then evaluated using 15 enantiomer pairs with focus on resolution, enantiomer elution order and chemoselectivity.
32709331	8	24	from	focus	1543:1547	arg1	chemoselectivity					1593:1608	chemoselectivity	1593:1608	chemoselectivity	1593:1608	The gain achievable by using the proposed sequence was then evaluated using 15 enantiomer pairs with focus on resolution, enantiomer elution order and chemoselectivity.
32709331	7	25	theme	solvent	1239:1245	arg1	mixtures					1247:1254	The solvent mixtures	1235:1254	The solvent mixtures that were eligible for practical application in these respects	1235:1317	The solvent mixtures that were eligible for practical application in these respects were used to construct a screening sequence, including identical compositions combined with different column pretreatment.
32709331	7	25	theme	solvent	1239:1245	arg1	eligible					1266:1273	eligible	1266:1273	eligible	1266:1273	The solvent mixtures that were eligible for practical application in these respects were used to construct a screening sequence, including identical compositions combined with different column pretreatment.
32709331	5	26	theme	common	1015:1020	arg1	approach					1022:1029	the common approach	1011:1029	the common approach where testing a library of compounds is required	1011:1078	The identification was carried out using a single diagnostic compound, as opposed to the common approach where testing a library of compounds is required.
32709331	0	27	theme	hysteresis	19:28	arg1	phenomenon					30:39	the hysteresis phenomenon	15:39	the hysteresis phenomenon	15:39	Utilization of the hysteresis phenomenon for chiral high-performance liquid chromatographic method selection in polar organic mode.
32709331	3	28	theme	present	544:550	arg1	study					552:556	the present study	540:556	the present study	540:556	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	6	29	theme	stability	1182:1190	arg1	terms					1173:1177	terms	1173:1177	terms of stability and robustness of the observed retentions	1173:1232	Eluent mixtures consisting of 2-propanol and either methanol or ethanol were scrutinized in terms of stability and robustness of the observed retentions.
32709331	1	30	theme	high	294:297	arg1	rates					307:311	high success rates	294:311	high success rates	294:311	Polysaccharide-based chiral stationary phases (CSPs) are outstandingly suitable to play a key role in chiral HPLC method selection strategies, since they provide high success rates.
32709331	4	31	theme	selector	866:873	arg1	states					845:850	distinct states	836:850	distinct states of the chiral selector	836:873	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	0	32	from	selection	99:107	arg1	mode					126:129	polar organic mode	112:129	polar organic mode	112:129	Utilization of the hysteresis phenomenon for chiral high-performance liquid chromatographic method selection in polar organic mode.
32709331	6	33	theme	Eluent	1081:1086	arg1	mixtures					1088:1095	Eluent mixtures	1081:1095	Eluent mixtures consisting of 2-propanol and either methanol or ethanol	1081:1151	Eluent mixtures consisting of 2-propanol and either methanol or ethanol were scrutinized in terms of stability and robustness of the observed retentions.
32709331	2	34	theme	various	403:409	arg1	eluents					411:417	various eluents	403:417	various eluents	403:417	One reason for this ability is that they adopt a diversity of higher order structures in various eluents, resulting in versatile chiral environments.
32709331	1	35	theme	success	299:305	arg1	rates					307:311	high success rates	294:311	high success rates	294:311	Polysaccharide-based chiral stationary phases (CSPs) are outstandingly suitable to play a key role in chiral HPLC method selection strategies, since they provide high success rates.
32709331	3	36	theme	selector	636:643	arg1	behavior					603:610	the recently discovered hysteretic behavior	568:610	the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate)	568:691	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	4	37	theme	separation	784:793	arg1	ability					795:801	its separation ability	780:801	its separation ability	780:801	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	1	38	theme	key	222:224	arg1	role					226:229	a key role	220:229	a key role	220:229	Polysaccharide-based chiral stationary phases (CSPs) are outstandingly suitable to play a key role in chiral HPLC method selection strategies, since they provide high success rates.
32709331	0	39	theme	phenomenon	30:39	arg1	Utilization					0:10	Utilization	0:10	Utilization of the hysteresis phenomenon for chiral high-performance liquid chromatographic method	0:97	Utilization of the hysteresis phenomenon for chiral high-performance liquid chromatographic method selection in polar organic mode.
32709331	7	40	theme	screening	1344:1352	arg1	sequence					1354:1361	a screening sequence	1342:1361	a screening sequence	1342:1361	The solvent mixtures that were eligible for practical application in these respects were used to construct a screening sequence, including identical compositions combined with different column pretreatment.
32709331	7	41	theme	practical	1279:1287	arg1	application					1289:1299	practical application	1279:1299	practical application in these respects	1279:1317	The solvent mixtures that were eligible for practical application in these respects were used to construct a screening sequence, including identical compositions combined with different column pretreatment.
32709331	3	42	theme	discovered	581:590	arg1	behavior					603:610	the recently discovered hysteretic behavior	568:610	the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate)	568:691	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	2	43	theme	structures	389:398	arg1	diversity					363:371	a diversity	361:371	a diversity of higher order structures	361:398	One reason for this ability is that they adopt a diversity of higher order structures in various eluents, resulting in versatile chiral environments.
32709331	0	44	theme	high-performance	52:67	arg1	method					92:97	chiral high-performance liquid chromatographic method	45:97	chiral high-performance liquid chromatographic method	45:97	Utilization of the hysteresis phenomenon for chiral high-performance liquid chromatographic method selection in polar organic mode.
32709331	3	45	theme	used	624:627	arg1	CS					646:647	CS	646:647	CS	646:647	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	3	45	theme	used	624:627	arg1	selector					636:643	a widely used chiral selector	615:643	a widely used chiral selector (CS)	615:648	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	3	45	theme	used	624:627	arg1	tris					659:662	amylose tris	651:662	amylose tris(3,5-dimethylphenylcarbamate)	651:691	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	5	46	theme	diagnostic	976:985	arg1	compound					987:994	a single diagnostic compound	967:994	a single diagnostic compound	967:994	The identification was carried out using a single diagnostic compound, as opposed to the common approach where testing a library of compounds is required.
32709331	0	47	theme	chiral	45:50	arg1	method					92:97	chiral high-performance liquid chromatographic method	45:97	chiral high-performance liquid chromatographic method	45:97	Utilization of the hysteresis phenomenon for chiral high-performance liquid chromatographic method selection in polar organic mode.
32709331	2	48	theme	chiral	443:448	arg1	environments					450:461	versatile chiral environments	433:461	versatile chiral environments	433:461	One reason for this ability is that they adopt a diversity of higher order structures in various eluents, resulting in versatile chiral environments.
32709331	4	49	theme	ability	795:801	arg1	dependence					766:775	the history dependence	754:775	the history dependence of its separation ability	754:801	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	1	50	theme	Polysaccharide-based	132:151	arg1	CSPs					179:182	CSPs	179:182	CSPs	179:182	Polysaccharide-based chiral stationary phases (CSPs) are outstandingly suitable to play a key role in chiral HPLC method selection strategies, since they provide high success rates.
32709331	1	50	theme	Polysaccharide-based	132:151	arg1	phases					171:176	Polysaccharide-based chiral stationary phases	132:176	Polysaccharide-based chiral stationary phases (CSPs)	132:183	Polysaccharide-based chiral stationary phases (CSPs) are outstandingly suitable to play a key role in chiral HPLC method selection strategies, since they provide high success rates.
32709331	4	51	used	used	809:812	arg2	transitions					707:717	The hindered transitions	694:717	The hindered transitions of its structure, which are behind the history dependence of its separation ability,	694:802	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	4	51	used	used	809:812	arg2	tool					819:822	a tool	817:822	a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space	817:923	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	4	52	theme	chiral	859:864	arg1	selector					866:873	the chiral selector	855:873	the chiral selector	855:873	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	4	53	theme	history	758:764	arg1	dependence					766:775	the history dependence	754:775	the history dependence of its separation ability	754:801	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	5	54	theme	single	969:974	arg1	compound					987:994	a single diagnostic compound	967:994	a single diagnostic compound	967:994	The identification was carried out using a single diagnostic compound, as opposed to the common approach where testing a library of compounds is required.
32709331	1	55	theme	chiral	153:158	arg1	CSPs					179:182	CSPs	179:182	CSPs	179:182	Polysaccharide-based chiral stationary phases (CSPs) are outstandingly suitable to play a key role in chiral HPLC method selection strategies, since they provide high success rates.
32709331	1	55	theme	chiral	153:158	arg1	phases					171:176	Polysaccharide-based chiral stationary phases	132:176	Polysaccharide-based chiral stationary phases (CSPs)	132:183	Polysaccharide-based chiral stationary phases (CSPs) are outstandingly suitable to play a key role in chiral HPLC method selection strategies, since they provide high success rates.
32709331	4	56	theme	structure	726:734	arg1	transitions					707:717	The hindered transitions	694:717	The hindered transitions of its structure, which are behind the history dependence of its separation ability,	694:802	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	4	56	theme	structure	726:734	arg1	tool					819:822	a tool	817:822	a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space	817:923	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	8	57	theme	elution	1575:1581	arg1	order					1583:1587	enantiomer elution order	1564:1587	enantiomer elution order	1564:1587	The gain achievable by using the proposed sequence was then evaluated using 15 enantiomer pairs with focus on resolution, enantiomer elution order and chemoselectivity.
32709331	1	58	theme	stationary	160:169	arg1	CSPs					179:182	CSPs	179:182	CSPs	179:182	Polysaccharide-based chiral stationary phases (CSPs) are outstandingly suitable to play a key role in chiral HPLC method selection strategies, since they provide high success rates.
32709331	1	58	theme	stationary	160:169	arg1	phases					171:176	Polysaccharide-based chiral stationary phases	132:176	Polysaccharide-based chiral stationary phases (CSPs)	132:183	Polysaccharide-based chiral stationary phases (CSPs) are outstandingly suitable to play a key role in chiral HPLC method selection strategies, since they provide high success rates.
32709331	1	59	theme	chiral	234:239	arg1	strategies					263:272	chiral HPLC method selection strategies	234:272	chiral HPLC method selection strategies	234:272	Polysaccharide-based chiral stationary phases (CSPs) are outstandingly suitable to play a key role in chiral HPLC method selection strategies, since they provide high success rates.
32709331	0	60	theme	chromatographic	76:90	arg1	method					92:97	chiral high-performance liquid chromatographic method	45:97	chiral high-performance liquid chromatographic method	45:97	Utilization of the hysteresis phenomenon for chiral high-performance liquid chromatographic method selection in polar organic mode.
32709331	3	61	theme	hysteretic	592:601	arg1	behavior					603:610	the recently discovered hysteretic behavior	568:610	the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate)	568:691	A potential to extend this versatility further was expected and examined in the present study, based on the recently discovered hysteretic behavior of a widely used chiral selector (CS), amylose tris(3,5-dimethylphenylcarbamate).
32709331	1	62	theme	HPLC	241:244	arg1	strategies					263:272	chiral HPLC method selection strategies	234:272	chiral HPLC method selection strategies	234:272	Polysaccharide-based chiral stationary phases (CSPs) are outstandingly suitable to play a key role in chiral HPLC method selection strategies, since they provide high success rates.
32709331	0	63	theme	liquid	69:74	arg1	method					92:97	chiral high-performance liquid chromatographic method	45:97	chiral high-performance liquid chromatographic method	45:97	Utilization of the hysteresis phenomenon for chiral high-performance liquid chromatographic method selection in polar organic mode.
32709331	5	64	theme	compounds	1058:1066	arg1	library					1047:1053	a library	1045:1053	a library of compounds	1045:1066	The identification was carried out using a single diagnostic compound, as opposed to the common approach where testing a library of compounds is required.
32709331	4	65	theme	extended	898:905	arg1	space					919:923	an extended selectivity space	895:923	an extended selectivity space	895:923	The hindered transitions of its structure, which are behind the history dependence of its separation ability, were used as a tool to identify distinct states of the chiral selector in order to exploit an extended selectivity space.
32709331	6	66	theme	retentions	1223:1232	arg1	robustness					1196:1205	robustness	1196:1205	robustness	1196:1205	Eluent mixtures consisting of 2-propanol and either methanol or ethanol were scrutinized in terms of stability and robustness of the observed retentions.
32709331	6	66	theme	retentions	1223:1232	arg1	stability					1182:1190	stability	1182:1190	stability	1182:1190	Eluent mixtures consisting of 2-propanol and either methanol or ethanol were scrutinized in terms of stability and robustness of the observed retentions.
32709331	1	67	theme	method	246:251	arg1	strategies					263:272	chiral HPLC method selection strategies	234:272	chiral HPLC method selection strategies	234:272	Polysaccharide-based chiral stationary phases (CSPs) are outstandingly suitable to play a key role in chiral HPLC method selection strategies, since they provide high success rates.
32560165	0	0	theme	Chitosan	92:99	arg1	Dispersion					101:110	Negatively Charged Chitosan Dispersion	73:110	Negatively Charged Chitosan Dispersion	73:110	Chitosan and Natural Rubber Latex Biocomposite Prepared by Incorporating Negatively Charged Chitosan Dispersion.
32560165	3	1	contain	have	465:468	arg2	charge					481:486	a negative charge	470:486	a negative charge that could be dispersed in water by using a ball mill before mixing with NRL	470:563	CT particles were prepared to have a negative charge that could be dispersed in water by using a ball mill before mixing with NRL.
32560165	3	1	contain	have	465:468	arg1	particles					438:446	CT particles	435:446	CT particles	435:446	CT particles were prepared to have a negative charge that could be dispersed in water by using a ball mill before mixing with NRL.
32560165	1	2	theme	acid	240:243	arg1	solution					245:252	CT acid solution	237:252	CT acid solution	237:252	Generally, natural rubber/chitosan (NR/CT) biocomposites could be prepared by either mixing natural rubber latex (NRL) with CT acid solution or mixing dry NR with CT powder on mixing equipment.
32560165	0	3	theme	Charged	84:90	arg1	Dispersion					101:110	Negatively Charged Chitosan Dispersion	73:110	Negatively Charged Chitosan Dispersion	73:110	Chitosan and Natural Rubber Latex Biocomposite Prepared by Incorporating Negatively Charged Chitosan Dispersion.
32560165	7	4	from	modulus	1031:1037	arg1	conjunction					1047:1057	conjunction	1047:1057	conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus)	1047:1136	Additionally, the presence of CT in the biocomposite resulted in an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus).
32560165	1	5	from	powder	279:284	arg1	equipment					296:304	mixing equipment	289:304	mixing equipment	289:304	Generally, natural rubber/chitosan (NR/CT) biocomposites could be prepared by either mixing natural rubber latex (NRL) with CT acid solution or mixing dry NR with CT powder on mixing equipment.
32560165	3	6	theme	negative	472:479	arg1	charge					481:486	a negative charge	470:486	a negative charge that could be dispersed in water by using a ball mill before mixing with NRL	470:563	CT particles were prepared to have a negative charge that could be dispersed in water by using a ball mill before mixing with NRL.
32560165	7	7	theme	antibacterial	1073:1085	arg1	activity					1087:1094	enhanced antibacterial activity	1064:1094	enhanced antibacterial activity against Staphylococcus aureus (S. aureus)	1064:1136	Additionally, the presence of CT in the biocomposite resulted in an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus).
32560165	7	8	theme	enhanced	1064:1071	arg1	activity					1087:1094	enhanced antibacterial activity	1064:1094	enhanced antibacterial activity against Staphylococcus aureus (S. aureus)	1064:1136	Additionally, the presence of CT in the biocomposite resulted in an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus).
32560165	6	9	theme	%	831:831	arg1	modulus					833:839	300% modulus	828:839	300% modulus of the NR/CT biocomposite film	828:870	With increasing CT loading from 0 to 8 phr, 300% modulus of the NR/CT biocomposite film increased, whereas the opposite trend was found for elongation at break.
32560165	4	10	theme	films	681:685	arg1	properties					624:633	latex properties	618:633	latex properties	618:633	The effects of CT loading varied from 0 to 8 phr on latex properties and physical properties of NR/CT biocomposite films were focused.
32560165	4	10	theme	films	681:685	arg1	properties					648:657	physical properties	639:657	physical properties	639:657	The effects of CT loading varied from 0 to 8 phr on latex properties and physical properties of NR/CT biocomposite films were focused.
32560165	6	11	theme	opposite	895:902	arg1	trend					904:908	the opposite trend	891:908	the opposite trend	891:908	With increasing CT loading from 0 to 8 phr, 300% modulus of the NR/CT biocomposite film increased, whereas the opposite trend was found for elongation at break.
32560165	2	12	theme	present	314:320	arg1	work					322:325	the present work	310:325	the present work	310:325	In the present work, a new mixing method has been proposed and properties of the obtained NR/CT biocomposites are investigated.
32560165	7	13	theme	CT	975:976	arg1	presence					963:970	the presence	959:970	the presence of CT in the biocomposite	959:996	Additionally, the presence of CT in the biocomposite resulted in an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus).
32560165	3	14	theme	CT	435:436	arg1	particles					438:446	CT particles	435:446	CT particles	435:446	CT particles were prepared to have a negative charge that could be dispersed in water by using a ball mill before mixing with NRL.
32560165	4	15	dep	8	609:609	arg1	to					606:607	to	606:607	to	606:607	The effects of CT loading varied from 0 to 8 phr on latex properties and physical properties of NR/CT biocomposite films were focused.
32560165	6	16	dep	8	821:821	arg1	to					818:819	to	818:819	to	818:819	With increasing CT loading from 0 to 8 phr, 300% modulus of the NR/CT biocomposite film increased, whereas the opposite trend was found for elongation at break.
32560165	4	17	theme	loading	584:590	arg1	effects					570:576	The effects	566:576	The effects of CT loading varied from 0 to 8 phr on latex properties and physical properties of NR/CT biocomposite films	566:685	The effects of CT loading varied from 0 to 8 phr on latex properties and physical properties of NR/CT biocomposite films were focused.
32560165	2	18	theme	biocomposites	403:415	arg1	properties					370:379	properties	370:379	properties of the obtained NR/CT biocomposites	370:415	In the present work, a new mixing method has been proposed and properties of the obtained NR/CT biocomposites are investigated.
32560165	6	19	theme	CT	800:801	arg1	loading					803:809	CT loading	800:809	CT loading	800:809	With increasing CT loading from 0 to 8 phr, 300% modulus of the NR/CT biocomposite film increased, whereas the opposite trend was found for elongation at break.
32560165	6	20	theme	film	867:870	arg1	modulus					833:839	300% modulus	828:839	300% modulus of the NR/CT biocomposite film	828:870	With increasing CT loading from 0 to 8 phr, 300% modulus of the NR/CT biocomposite film increased, whereas the opposite trend was found for elongation at break.
32560165	7	21	dep	aureus	1119:1124	arg1	aureus					1130:1135	S. aureus	1127:1135	S. aureus	1127:1135	Additionally, the presence of CT in the biocomposite resulted in an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus).
32560165	2	22	theme	NR/CT	397:401	arg1	biocomposites					403:415	the obtained NR/CT biocomposites	384:415	the obtained NR/CT biocomposites	384:415	In the present work, a new mixing method has been proposed and properties of the obtained NR/CT biocomposites are investigated.
32560165	1	23	theme	dry	264:266	arg1	NR					268:269	dry NR	264:269	dry NR	264:269	Generally, natural rubber/chitosan (NR/CT) biocomposites could be prepared by either mixing natural rubber latex (NRL) with CT acid solution or mixing dry NR with CT powder on mixing equipment.
32560165	6	24	located	found	914:918	arg2	trend					904:908	the opposite trend	891:908	the opposite trend	891:908	With increasing CT loading from 0 to 8 phr, 300% modulus of the NR/CT biocomposite film increased, whereas the opposite trend was found for elongation at break.
32560165	6	24	located	found	914:918	arg1	break					938:942	break	938:942	break	938:942	With increasing CT loading from 0 to 8 phr, 300% modulus of the NR/CT biocomposite film increased, whereas the opposite trend was found for elongation at break.
32560165	2	25	theme	mixing	334:339	arg1	method					341:346	a new mixing method	328:346	a new mixing method	328:346	In the present work, a new mixing method has been proposed and properties of the obtained NR/CT biocomposites are investigated.
32560165	2	26	theme	obtained	388:395	arg1	biocomposites					403:415	the obtained NR/CT biocomposites	384:415	the obtained NR/CT biocomposites	384:415	In the present work, a new mixing method has been proposed and properties of the obtained NR/CT biocomposites are investigated.
32560165	6	27	theme	biocomposite	854:865	arg1	film					867:870	the NR/CT biocomposite film	844:870	the NR/CT biocomposite film	844:870	With increasing CT loading from 0 to 8 phr, 300% modulus of the NR/CT biocomposite film increased, whereas the opposite trend was found for elongation at break.
32560165	4	28	theme	biocomposite	668:679	arg1	films					681:685	NR/CT biocomposite films	662:685	NR/CT biocomposite films	662:685	The effects of CT loading varied from 0 to 8 phr on latex properties and physical properties of NR/CT biocomposite films were focused.
32560165	1	29	theme	natural	205:211	arg1	NRL					227:229	NRL	227:229	NRL	227:229	Generally, natural rubber/chitosan (NR/CT) biocomposites could be prepared by either mixing natural rubber latex (NRL) with CT acid solution or mixing dry NR with CT powder on mixing equipment.
32560165	1	29	theme	natural	205:211	arg1	latex					220:224	natural rubber latex	205:224	natural rubber latex (NRL)	205:230	Generally, natural rubber/chitosan (NR/CT) biocomposites could be prepared by either mixing natural rubber latex (NRL) with CT acid solution or mixing dry NR with CT powder on mixing equipment.
32560165	0	30	theme	Natural	13:19	arg1	Latex					28:32	Natural Rubber Latex	13:32	Natural Rubber Latex	13:32	Chitosan and Natural Rubber Latex Biocomposite Prepared by Incorporating Negatively Charged Chitosan Dispersion.
32560165	6	31	theme	NR/CT	848:852	arg1	film					867:870	the NR/CT biocomposite film	844:870	the NR/CT biocomposite film	844:870	With increasing CT loading from 0 to 8 phr, 300% modulus of the NR/CT biocomposite film increased, whereas the opposite trend was found for elongation at break.
32560165	4	32	theme	NR/CT	662:666	arg1	films					681:685	NR/CT biocomposite films	662:685	NR/CT biocomposite films	662:685	The effects of CT loading varied from 0 to 8 phr on latex properties and physical properties of NR/CT biocomposite films were focused.
32560165	4	33	from	effects	570:576	arg1	properties					624:633	latex properties	618:633	latex properties	618:633	The effects of CT loading varied from 0 to 8 phr on latex properties and physical properties of NR/CT biocomposite films were focused.
32560165	4	33	from	effects	570:576	arg1	properties					648:657	physical properties	639:657	physical properties	639:657	The effects of CT loading varied from 0 to 8 phr on latex properties and physical properties of NR/CT biocomposite films were focused.
32560165	1	34	theme	rubber	213:218	arg1	NRL					227:229	NRL	227:229	NRL	227:229	Generally, natural rubber/chitosan (NR/CT) biocomposites could be prepared by either mixing natural rubber latex (NRL) with CT acid solution or mixing dry NR with CT powder on mixing equipment.
32560165	1	34	theme	rubber	213:218	arg1	latex					220:224	natural rubber latex	205:224	natural rubber latex (NRL)	205:230	Generally, natural rubber/chitosan (NR/CT) biocomposites could be prepared by either mixing natural rubber latex (NRL) with CT acid solution or mixing dry NR with CT powder on mixing equipment.
32560165	7	35	theme	elastic	1023:1029	arg1	E					1040:1040	E'	1040:1041	E'	1040:1041	Additionally, the presence of CT in the biocomposite resulted in an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus).
32560165	7	35	theme	elastic	1023:1029	arg1	modulus					1031:1037	an increased elastic modulus	1010:1037	an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus)	1010:1136	Additionally, the presence of CT in the biocomposite resulted in an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus).
32560165	1	36	theme	CT	276:277	arg1	powder					279:284	CT powder	276:284	CT powder on mixing equipment	276:304	Generally, natural rubber/chitosan (NR/CT) biocomposites could be prepared by either mixing natural rubber latex (NRL) with CT acid solution or mixing dry NR with CT powder on mixing equipment.
32560165	4	37	theme	CT	581:582	arg1	loading					584:590	CT loading	581:590	CT loading varied from 0 to 8 phr	581:613	The effects of CT loading varied from 0 to 8 phr on latex properties and physical properties of NR/CT biocomposite films were focused.
32560165	4	38	theme	latex	618:622	arg1	properties					624:633	latex properties	618:633	latex properties	618:633	The effects of CT loading varied from 0 to 8 phr on latex properties and physical properties of NR/CT biocomposite films were focused.
32560165	0	39	theme	Rubber	21:26	arg1	Latex					28:32	Natural Rubber Latex	13:32	Natural Rubber Latex	13:32	Chitosan and Natural Rubber Latex Biocomposite Prepared by Incorporating Negatively Charged Chitosan Dispersion.
32560165	5	40	theme	CT	772:773	arg1	loading					775:781	CT loading	772:781	CT loading	772:781	The results showed that the viscosity of NRL increased with increasing CT loading.
32560165	0	41	dep	Biocomposite	34:45	arg1	Prepared					47:54	Prepared	47:54	Biocomposite Prepared by Incorporating Negatively Charged Chitosan Dispersion	34:110	Chitosan and Natural Rubber Latex Biocomposite Prepared by Incorporating Negatively Charged Chitosan Dispersion.
32560165	1	42	theme	natural	124:130	arg1	biocomposites					156:168	natural rubber/chitosan (NR/CT) biocomposites	124:168	natural rubber/chitosan (NR/CT) biocomposites	124:168	Generally, natural rubber/chitosan (NR/CT) biocomposites could be prepared by either mixing natural rubber latex (NRL) with CT acid solution or mixing dry NR with CT powder on mixing equipment.
32560165	7	43	theme	increased	1013:1021	arg1	E					1040:1040	E'	1040:1041	E'	1040:1041	Additionally, the presence of CT in the biocomposite resulted in an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus).
32560165	7	43	theme	increased	1013:1021	arg1	modulus					1031:1037	an increased elastic modulus	1010:1037	an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus)	1010:1136	Additionally, the presence of CT in the biocomposite resulted in an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus).
32560165	1	44	theme	mixing	289:294	arg1	equipment					296:304	mixing equipment	289:304	mixing equipment	289:304	Generally, natural rubber/chitosan (NR/CT) biocomposites could be prepared by either mixing natural rubber latex (NRL) with CT acid solution or mixing dry NR with CT powder on mixing equipment.
32560165	7	45	from	presence	963:970	arg1	biocomposite					985:996	the biocomposite	981:996	the biocomposite	981:996	Additionally, the presence of CT in the biocomposite resulted in an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus).
32560165	3	46	theme	ball	532:535	arg1	mill					537:540	a ball mill	530:540	a ball mill	530:540	CT particles were prepared to have a negative charge that could be dispersed in water by using a ball mill before mixing with NRL.
32560165	1	47	theme	rubber/chitosan	132:146	arg1	biocomposites					156:168	natural rubber/chitosan (NR/CT) biocomposites	124:168	natural rubber/chitosan (NR/CT) biocomposites	124:168	Generally, natural rubber/chitosan (NR/CT) biocomposites could be prepared by either mixing natural rubber latex (NRL) with CT acid solution or mixing dry NR with CT powder on mixing equipment.
32560165	6	48	theme	300	828:830	arg1	%					831:831	%	831:831	%	831:831	With increasing CT loading from 0 to 8 phr, 300% modulus of the NR/CT biocomposite film increased, whereas the opposite trend was found for elongation at break.
32560165	7	49	with	conjunction	1047:1057	arg1	activity					1087:1094	enhanced antibacterial activity	1064:1094	enhanced antibacterial activity against Staphylococcus aureus (S. aureus)	1064:1136	Additionally, the presence of CT in the biocomposite resulted in an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus).
32560165	4	50	theme	physical	639:646	arg1	properties					648:657	physical properties	639:657	physical properties	639:657	The effects of CT loading varied from 0 to 8 phr on latex properties and physical properties of NR/CT biocomposite films were focused.
32560165	1	51	theme	NR/CT	149:153	arg1	biocomposites					156:168	natural rubber/chitosan (NR/CT) biocomposites	124:168	natural rubber/chitosan (NR/CT) biocomposites	124:168	Generally, natural rubber/chitosan (NR/CT) biocomposites could be prepared by either mixing natural rubber latex (NRL) with CT acid solution or mixing dry NR with CT powder on mixing equipment.
32560165	3	52	with	mixing	549:554	arg1	NRL					561:563	NRL	561:563	NRL	561:563	CT particles were prepared to have a negative charge that could be dispersed in water by using a ball mill before mixing with NRL.
32560165	2	53	theme	new	330:332	arg1	method					341:346	a new mixing method	328:346	a new mixing method	328:346	In the present work, a new mixing method has been proposed and properties of the obtained NR/CT biocomposites are investigated.
32560165	7	54	attach	presence	963:970	arg1	biocomposite					985:996	the biocomposite	981:996	the biocomposite	981:996	Additionally, the presence of CT in the biocomposite resulted in an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus).
32560165	7	54	attach	presence	963:970	arg2	CT					975:976	CT	975:976	CT	975:976	Additionally, the presence of CT in the biocomposite resulted in an increased elastic modulus (E') in conjunction with enhanced antibacterial activity against Staphylococcus aureus (S. aureus).
32560165	5	55	theme	NRL	742:744	arg1	viscosity					729:737	the viscosity	725:737	the viscosity of NRL	725:744	The results showed that the viscosity of NRL increased with increasing CT loading.
32560165	1	56	theme	CT	237:238	arg1	solution					245:252	CT acid solution	237:252	CT acid solution	237:252	Generally, natural rubber/chitosan (NR/CT) biocomposites could be prepared by either mixing natural rubber latex (NRL) with CT acid solution or mixing dry NR with CT powder on mixing equipment.
32011853	2	0	from	polymer	467:473	arg1	embedded					433:440	embedded	433:440	embedded	433:440	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	6	1	theme	wearable	1303:1310	arg1	diagnostics					1323:1333	wearable biomedical diagnostics	1303:1333	wearable biomedical diagnostics	1303:1333	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
32011853	2	2	theme	few	408:410	arg1	millimeters					412:422	a few millimeters	406:422	a few millimeters	406:422	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	5	3	from	Hz	1007:1008	arg1	range					992:996	a frequency range	980:996	a frequency range from 100 Hz to 1 MHz	980:1017	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	4	4	with	film	766:769	arg1	mV					801:802	∼2.82 ± 0.2 mV kPa-1	789:808	∼2.82 ± 0.2 mV kPa-1	789:808	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	4	4	with	film	766:769	arg1	sensitivity					776:786	sensitivity	776:786	sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials	776:881	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	3	5	theme	X-ray	544:548	arg1	diffraction					550:560	X-ray diffraction	544:560	X-ray diffraction	544:560	The polymorphic phase of glycine crystals in chitosan, evaluated by X-ray diffraction, confirms formation of a pure ferroelectric phase of glycine (β-phase).
32011853	5	6	from	range	992:996	arg1	range					950:954	the range	946:954	the range from 0.26 to 0.12 nF	946:975	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	5	6	from	range	992:996	arg1	range					1118:1122	the high impedance range	1099:1122	the high impedance range	1099:1122	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	4	7	theme	comparable	811:820	arg1	mV					801:802	∼2.82 ± 0.2 mV kPa-1	789:808	∼2.82 ± 0.2 mV kPa-1	789:808	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	4	7	theme	comparable	811:820	arg1	sensitivity					776:786	sensitivity	776:786	sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials	776:881	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	3	8	theme	glycine	615:621	arg1	phase					606:610	a pure ferroelectric phase	585:610	a pure ferroelectric phase of glycine (β-phase)	585:631	The polymorphic phase of glycine crystals in chitosan, evaluated by X-ray diffraction, confirms formation of a pure ferroelectric phase of glycine (β-phase).
32011853	2	9	theme	stable	346:351	arg1	structure					364:372	a stable spherulite structure	344:372	a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer	344:473	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	2	10	theme	spherulite	353:362	arg1	structure					364:372	a stable spherulite structure	344:372	a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer	344:473	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	3	11	theme	phase	606:610	arg1	formation					572:580	formation	572:580	formation of a pure ferroelectric phase of glycine (β-phase)	572:631	The polymorphic phase of glycine crystals in chitosan, evaluated by X-ray diffraction, confirms formation of a pure ferroelectric phase of glycine (β-phase).
32011853	5	12	dep	0.12	969:972	arg1	to					966:967	to	966:967	to	966:967	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	4	13	theme	biodegradable	713:725	arg1	film					766:769	a biodegradable β-glycine/chitosan-based piezoelectric film	711:769	a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials	711:881	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	3	14	theme	crystals	509:516	arg1	phase					492:496	The polymorphic phase	476:496	The polymorphic phase	476:496	The polymorphic phase of glycine crystals in chitosan, evaluated by X-ray diffraction, confirms formation of a pure ferroelectric phase of glycine (β-phase).
32011853	1	15	theme	flexible	97:104	arg1	sensors					115:121	flexible pressure sensors	97:121	flexible pressure sensors based on free-standing and biodegradable glycine-chitosan piezoelectric films	97:199	This paper presents flexible pressure sensors based on free-standing and biodegradable glycine-chitosan piezoelectric films.
32011853	2	16	theme	embedded	433:440	arg1	β-glycine					377:385	β-glycine	377:385	β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer	377:473	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	6	17	theme	biodegradable	1261:1273	arg1	sensors					1275:1281	biodegradable sensors	1261:1281	biodegradable sensors for applications in wearable biomedical diagnostics	1261:1333	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
32011853	1	18	theme	pressure	106:113	arg1	sensors					115:121	flexible pressure sensors	97:121	flexible pressure sensors based on free-standing and biodegradable glycine-chitosan piezoelectric films	97:199	This paper presents flexible pressure sensors based on free-standing and biodegradable glycine-chitosan piezoelectric films.
32011853	3	19	theme	polymorphic	480:490	arg1	phase					492:496	The polymorphic phase	476:496	The polymorphic phase	476:496	The polymorphic phase of glycine crystals in chitosan, evaluated by X-ray diffraction, confirms formation of a pure ferroelectric phase of glycine (β-phase).
32011853	0	20	theme	Flexible	23:30	arg1	Sensor					69:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor	0:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor	0:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor.
32011853	3	21	from	chitosan	521:528	arg1	phase					492:496	The polymorphic phase	476:496	The polymorphic phase	476:496	The polymorphic phase of glycine crystals in chitosan, evaluated by X-ray diffraction, confirms formation of a pure ferroelectric phase of glycine (β-phase).
32011853	2	22	theme	β-glycine	377:385	arg1	structure					364:372	a stable spherulite structure	344:372	a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer	344:473	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	5	23	theme	β-glycine/chitosan	916:933	arg1	film					935:938	the β-glycine/chitosan film	912:938	the β-glycine/chitosan film	912:938	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	0	24	theme	Glycine-Chitosan-Based	0:21	arg1	Sensor					69:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor	0:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor	0:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor.
32011853	3	25	theme	ferroelectric	592:604	arg1	phase					606:610	a pure ferroelectric phase	585:610	a pure ferroelectric phase of glycine (β-phase)	585:631	The polymorphic phase of glycine crystals in chitosan, evaluated by X-ray diffraction, confirms formation of a pure ferroelectric phase of glycine (β-phase).
32011853	5	26	theme	film	935:938	arg1	capacitance					897:907	The measured capacitance	884:907	The measured capacitance of the β-glycine/chitosan film	884:938	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	0	27	theme	Piezoelectric	46:58	arg1	Sensor					69:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor	0:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor	0:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor.
32011853	6	28	theme	promising	1211:1219	arg1	material					1248:1255	a promising new biobased piezoelectric material	1209:1255	a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics	1209:1333	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
32011853	6	28	theme	promising	1211:1219	arg1	composite					1196:1204	the glycine-chitosan composite	1175:1204	the glycine-chitosan composite	1175:1204	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
32011853	3	29	theme	pure	587:590	arg1	phase					606:610	a pure ferroelectric phase	585:610	a pure ferroelectric phase of glycine (β-phase)	585:631	The polymorphic phase of glycine crystals in chitosan, evaluated by X-ray diffraction, confirms formation of a pure ferroelectric phase of glycine (β-phase).
32011853	6	30	theme	piezoelectric	1234:1246	arg1	material					1248:1255	a promising new biobased piezoelectric material	1209:1255	a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics	1209:1333	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
32011853	6	30	theme	piezoelectric	1234:1246	arg1	composite					1196:1204	the glycine-chitosan composite	1175:1204	the glycine-chitosan composite	1175:1204	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
32011853	2	31	theme	chitosan	458:465	arg1	polymer					467:473	an amorphous chitosan polymer	445:473	an amorphous chitosan polymer	445:473	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	0	32	theme	Biodegradable	32:44	arg1	Sensor					69:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor	0:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor	0:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor.
32011853	5	33	theme	impedance	1108:1116	arg1	range					1118:1122	the high impedance range	1099:1122	the high impedance range	1099:1122	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	2	34	theme	biological	237:246	arg1	molecules					248:256	biological molecules	237:256	biological molecules of glycine within a water-based chitosan solution	237:306	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	1	35	theme	free-standing	132:144	arg1	films					195:199	free-standing and biodegradable glycine-chitosan piezoelectric films	132:199	free-standing and biodegradable glycine-chitosan piezoelectric films	132:199	This paper presents flexible pressure sensors based on free-standing and biodegradable glycine-chitosan piezoelectric films.
32011853	5	36	theme	dielectric	1028:1037	arg1	constant					1039:1046	its dielectric constant	1024:1046	its dielectric constant	1024:1046	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	2	37	theme	amorphous	448:456	arg1	polymer					467:473	an amorphous chitosan polymer	445:473	an amorphous chitosan polymer	445:473	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	4	38	theme	β-glycine/chitosan-based	727:750	arg1	film					766:769	a biodegradable β-glycine/chitosan-based piezoelectric film	711:769	a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials	711:881	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	6	39	theme	new	1221:1223	arg1	material					1248:1255	a promising new biobased piezoelectric material	1209:1255	a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics	1209:1333	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
32011853	6	39	theme	new	1221:1223	arg1	composite					1196:1204	the glycine-chitosan composite	1175:1204	the glycine-chitosan composite	1175:1204	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
32011853	5	40	theme	measured	888:895	arg1	capacitance					897:907	The measured capacitance	884:907	The measured capacitance of the β-glycine/chitosan film	884:938	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	4	41	theme	commercial	848:857	arg1	materials					873:881	nondegradable commercial piezoelectric materials	834:881	nondegradable commercial piezoelectric materials	834:881	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	4	42	theme	solvent-casting	665:679	arg1	method					681:686	a simple solvent-casting method	656:686	a simple solvent-casting method	656:686	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	0	43	theme	Pressure	60:67	arg1	Sensor					69:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor	0:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor	0:74	Glycine-Chitosan-Based Flexible Biodegradable Piezoelectric Pressure Sensor.
32011853	5	44	theme	ambient	1130:1136	arg1	conditions					1138:1147	ambient conditions	1130:1147	ambient conditions	1130:1147	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	2	45	theme	chitosan	290:297	arg1	solution					299:306	a water-based chitosan solution	276:306	a water-based chitosan solution	276:306	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	3	46	from	phase	492:496	arg1	chitosan					521:528	chitosan	521:528	chitosan	521:528	The polymorphic phase of glycine crystals in chitosan, evaluated by X-ray diffraction, confirms formation of a pure ferroelectric phase of glycine (β-phase).
32011853	4	47	theme	simple	658:663	arg1	method					681:686	a simple solvent-casting method	656:686	a simple solvent-casting method	656:686	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	5	48	theme	loss	1052:1055	arg1	factor					1057:1062	loss factor	1052:1062	loss factor	1052:1062	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	2	49	theme	water-based	278:288	arg1	solution					299:306	a water-based chitosan solution	276:306	a water-based chitosan solution	276:306	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	4	50	used	used	695:698	arg2	method					681:686	a simple solvent-casting method	656:686	a simple solvent-casting method	656:686	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	4	51	theme	piezoelectric	752:764	arg1	film					766:769	a biodegradable β-glycine/chitosan-based piezoelectric film	711:769	a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials	711:881	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	6	52	theme	biobased	1225:1232	arg1	material					1248:1255	a promising new biobased piezoelectric material	1209:1255	a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics	1209:1333	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
32011853	6	52	theme	biobased	1225:1232	arg1	composite					1196:1204	the glycine-chitosan composite	1175:1204	the glycine-chitosan composite	1175:1204	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
32011853	4	53	theme	piezoelectric	859:871	arg1	materials					873:881	nondegradable commercial piezoelectric materials	834:881	nondegradable commercial piezoelectric materials	834:881	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	2	54	from	embedded	433:440	arg1	polymer					467:473	an amorphous chitosan polymer	445:473	an amorphous chitosan polymer	445:473	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	1	55	theme	biodegradable	150:162	arg1	films					195:199	free-standing and biodegradable glycine-chitosan piezoelectric films	132:199	free-standing and biodegradable glycine-chitosan piezoelectric films	132:199	This paper presents flexible pressure sensors based on free-standing and biodegradable glycine-chitosan piezoelectric films.
32011853	4	56	theme	nondegradable	834:846	arg1	materials					873:881	nondegradable commercial piezoelectric materials	834:881	nondegradable commercial piezoelectric materials	834:881	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	2	57	theme	glycine	261:267	arg1	molecules					248:256	biological molecules	237:256	biological molecules of glycine within a water-based chitosan solution	237:306	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	3	58	from	crystals	509:516	arg1	chitosan					521:528	chitosan	521:528	chitosan	521:528	The polymorphic phase of glycine crystals in chitosan, evaluated by X-ray diffraction, confirms formation of a pure ferroelectric phase of glycine (β-phase).
32011853	1	59	theme	glycine-chitosan	164:179	arg1	films					195:199	free-standing and biodegradable glycine-chitosan piezoelectric films	132:199	free-standing and biodegradable glycine-chitosan piezoelectric films	132:199	This paper presents flexible pressure sensors based on free-standing and biodegradable glycine-chitosan piezoelectric films.
32011853	4	60	theme	±	795:795	arg1	mV					801:802	∼2.82 ± 0.2 mV kPa-1	789:808	∼2.82 ± 0.2 mV kPa-1	789:808	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	4	60	theme	±	795:795	arg1	sensitivity					776:786	sensitivity	776:786	sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials	776:881	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	6	61	from	applications	1287:1298	arg1	diagnostics					1323:1333	wearable biomedical diagnostics	1303:1333	wearable biomedical diagnostics	1303:1333	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
32011853	6	62	theme	biomedical	1312:1321	arg1	diagnostics					1323:1333	wearable biomedical diagnostics	1303:1333	wearable biomedical diagnostics	1303:1333	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
32011853	2	63	theme	piezoelectric	313:325	arg1	films					327:331	the piezoelectric films	309:331	the piezoelectric films	309:331	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	4	64	theme	∼2.82	789:793	arg1	mV					801:802	∼2.82 ± 0.2 mV kPa-1	789:808	∼2.82 ± 0.2 mV kPa-1	789:808	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	4	64	theme	∼2.82	789:793	arg1	sensitivity					776:786	sensitivity	776:786	sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials	776:881	Our results show that a simple solvent-casting method can be used to prepare a biodegradable β-glycine/chitosan-based piezoelectric film with sensitivity (∼2.82 ± 0.2 mV kPa-1) comparable to those of nondegradable commercial piezoelectric materials.
32011853	1	65	theme	piezoelectric	181:193	arg1	films					195:199	free-standing and biodegradable glycine-chitosan piezoelectric films	132:199	free-standing and biodegradable glycine-chitosan piezoelectric films	132:199	This paper presents flexible pressure sensors based on free-standing and biodegradable glycine-chitosan piezoelectric films.
32011853	5	66	from	nF	974:975	arg1	range					950:954	the range	946:954	the range from 0.26 to 0.12 nF	946:975	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	5	66	from	nF	974:975	arg1	range					1118:1122	the high impedance range	1099:1122	the high impedance range	1099:1122	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	2	67	dep	β-glycine	377:385	arg1	size					388:391	size	388:391	size varying from a few millimeters to 1 cm	388:430	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	2	68	theme	molecules	248:256	arg1	self-assembly					220:232	the self-assembly	216:232	the self-assembly of biological molecules of glycine within a water-based chitosan solution	216:306	Fabricated by the self-assembly of biological molecules of glycine within a water-based chitosan solution, the piezoelectric films consist of a stable spherulite structure of β-glycine (size varying from a few millimeters to 1 cm) embedded in an amorphous chitosan polymer.
32011853	3	69	theme	glycine	501:507	arg1	crystals					509:516	glycine crystals	501:516	glycine crystals in chitosan	501:528	The polymorphic phase of glycine crystals in chitosan, evaluated by X-ray diffraction, confirms formation of a pure ferroelectric phase of glycine (β-phase).
32011853	5	70	theme	frequency	982:990	arg1	range					992:996	a frequency range	980:996	a frequency range from 100 Hz to 1 MHz	980:1017	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	5	71	theme	high	1103:1106	arg1	range					1118:1122	the high impedance range	1099:1122	the high impedance range	1099:1122	The measured capacitance of the β-glycine/chitosan film is in the range from 0.26 to 0.12 nF at a frequency range from 100 Hz to 1 MHz, and its dielectric constant and loss factor are 7.7 and 0.18, respectively, in the high impedance range under ambient conditions.
32011853	6	72	theme	glycine-chitosan	1179:1194	arg1	material					1248:1255	a promising new biobased piezoelectric material	1209:1255	a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics	1209:1333	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
32011853	6	72	theme	glycine-chitosan	1179:1194	arg1	composite					1196:1204	the glycine-chitosan composite	1175:1204	the glycine-chitosan composite	1175:1204	The results suggest that the glycine-chitosan composite is a promising new biobased piezoelectric material for biodegradable sensors for applications in wearable biomedical diagnostics.
33730559	0	0	theme	tissue	84:89	arg1	structure					91:99	tissue structure	84:99	tissue structure	84:99	Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition.
33730559	10	1	theme	meniscal	1377:1384	arg1	content					1392:1398	meniscal water content	1377:1398	meniscal water content	1377:1398	Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples).
33730559	12	2	theme	Fiber	1735:1739	arg1	orientation					1741:1751	Fiber orientation	1735:1751	Fiber orientation	1735:1751	Fiber orientation did not affect the values of G, which ranged from ~50 to ~100 kPa.
33730559	10	3	with	G	1438:1438	arg1	collagen					1461:1468	collagen	1461:1468	collagen	1461:1468	Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples).
33730559	10	3	with	G	1438:1438	arg1	GAG					1453:1455	GAG	1453:1455	GAG	1453:1455	Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples).
33730559	9	4	theme	viscoelastic	1234:1245	arg1	behavior					1247:1254	viscoelastic behavior	1234:1254	viscoelastic behavior	1234:1254	The meniscus exhibited viscoelastic behavior.
33730559	7	5	theme	equilibrium	1078:1088	arg1	G					1105:1105	G	1105:1105	G	1105:1105	Frequency sweeps and stress relaxation tests yielded storage (G') and loss moduli (G″), and equilibrium shear modulus (G).
33730559	7	5	theme	equilibrium	1078:1088	arg1	modulus					1096:1102	equilibrium shear modulus	1078:1102	equilibrium shear modulus (G)	1078:1106	Frequency sweeps and stress relaxation tests yielded storage (G') and loss moduli (G″), and equilibrium shear modulus (G).
33730559	1	6	theme	knee	161:164	arg1	function					166:173	the knee function	157:173	the knee function	157:173	The meniscus is crucial in maintaining the knee function and protecting the joint from secondary pathologies, including osteoarthritis.
33730559	11	7	theme	mechanical	1609:1618	arg1	properties					1620:1629	superior dynamic mechanical properties	1592:1629	superior dynamic mechanical properties	1592:1629	Circumferential samples, with collagen fibers orthogonal to the shear plane, exhibited superior dynamic mechanical properties, with G' ~70 kPa and G″ ~10 kPa, compared to those of the axial plane ~15 kPa and ~1 kPa, respectively.
33730559	10	8	theme	circumferential	1479:1493	arg1	samples					1495:1501	circumferential samples	1479:1501	circumferential samples	1479:1501	Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples).
33730559	11	9	theme	orthogonal	1551:1560	arg1	fibers					1544:1549	collagen fibers	1535:1549	collagen fibers orthogonal to the shear plane	1535:1579	Circumferential samples, with collagen fibers orthogonal to the shear plane, exhibited superior dynamic mechanical properties, with G' ~70 kPa and G″ ~10 kPa, compared to those of the axial plane ~15 kPa and ~1 kPa, respectively.
33730559	2	10	theme	human	300:304	arg1	menisci					306:312	human menisci	300:312	human menisci	300:312	Although most of the mechanical properties of human menisci have been characterized, to our knowledge, its dynamic shear properties have never been reported.
33730559	6	11	theme	menisci	977:983	arg1	axial					907:911	axial	907:911	axial	907:911	Specimens were prepared from the axial and the circumferential anatomical planes of medial and lateral menisci.
33730559	5	12	from	relation	830:837	arg1	dynamic					768:774	dynamic	768:774	dynamic	768:774	Hence, the objective of this study was to characterize the dynamic and equilibrium shear properties of human meniscus in relation to its anisotropy and composition.
33730559	0	13	with	Relationships	65:77	arg1	composition					105:115	composition	105:115	composition	105:115	Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition.
33730559	0	13	with	Relationships	65:77	arg1	structure					91:99	tissue structure	84:99	tissue structure	84:99	Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition.
33730559	6	14	theme	lateral	969:975	arg1	menisci					977:983	medial and lateral menisci	958:983	medial and lateral menisci	958:983	Specimens were prepared from the axial and the circumferential anatomical planes of medial and lateral menisci.
33730559	7	15	theme	relaxation	1014:1023	arg1	tests					1025:1029	stress relaxation tests	1007:1029	stress relaxation tests	1007:1029	Frequency sweeps and stress relaxation tests yielded storage (G') and loss moduli (G″), and equilibrium shear modulus (G).
33730559	10	16	theme	positive	1401:1408	arg1	correlations					1410:1421	positive correlations	1401:1421	positive correlations	1401:1421	Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples).
33730559	5	17	theme	meniscus	818:825	arg1	dynamic					768:774	dynamic	768:774	dynamic	768:774	Hence, the objective of this study was to characterize the dynamic and equilibrium shear properties of human meniscus in relation to its anisotropy and composition.
33730559	11	18	theme	Circumferential	1505:1519	arg1	samples					1521:1527	Circumferential samples	1505:1527	Circumferential samples	1505:1527	Circumferential samples, with collagen fibers orthogonal to the shear plane, exhibited superior dynamic mechanical properties, with G' ~70 kPa and G″ ~10 kPa, compared to those of the axial plane ~15 kPa and ~1 kPa, respectively.
33730559	7	19	theme	shear	1090:1094	arg1	G					1105:1105	G	1105:1105	G	1105:1105	Frequency sweeps and stress relaxation tests yielded storage (G') and loss moduli (G″), and equilibrium shear modulus (G).
33730559	7	19	theme	shear	1090:1094	arg1	modulus					1096:1102	equilibrium shear modulus	1078:1102	equilibrium shear modulus (G)	1078:1106	Frequency sweeps and stress relaxation tests yielded storage (G') and loss moduli (G″), and equilibrium shear modulus (G).
33730559	11	20	theme	shear	1569:1573	arg1	plane					1575:1579	the shear plane	1565:1579	the shear plane	1565:1579	Circumferential samples, with collagen fibers orthogonal to the shear plane, exhibited superior dynamic mechanical properties, with G' ~70 kPa and G″ ~10 kPa, compared to those of the axial plane ~15 kPa and ~1 kPa, respectively.
33730559	10	21	dep	samples	1495:1501	arg1	only					1471:1474	only	1471:1474	only	1471:1474	Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples).
33730559	2	22	theme	mechanical	275:284	arg1	properties					286:295	the mechanical properties	271:295	the mechanical properties of human menisci	271:312	Although most of the mechanical properties of human menisci have been characterized, to our knowledge, its dynamic shear properties have never been reported.
33730559	5	23	theme	equilibrium	780:790	arg1	properties					798:807	the dynamic and equilibrium shear properties	764:807	properties	798:807	Hence, the objective of this study was to characterize the dynamic and equilibrium shear properties of human meniscus in relation to its anisotropy and composition.
33730559	7	24	theme	loss	1056:1059	arg1	G″					1069:1070	G″	1069:1070	G″	1069:1070	Frequency sweeps and stress relaxation tests yielded storage (G') and loss moduli (G″), and equilibrium shear modulus (G).
33730559	7	24	theme	loss	1056:1059	arg1	moduli					1061:1066	loss moduli	1056:1066	loss moduli (G″)	1056:1071	Frequency sweeps and stress relaxation tests yielded storage (G') and loss moduli (G″), and equilibrium shear modulus (G).
33730559	8	25	with	Correlations	1109:1120	arg1	water					1137:1141	water	1137:1141	water	1137:1141	Correlations of moduli with water, glycosaminoglycans (GAGs), and collagen content were investigated.
33730559	8	25	with	Correlations	1109:1120	arg1	content					1184:1190	collagen content	1175:1190	collagen content	1175:1190	Correlations of moduli with water, glycosaminoglycans (GAGs), and collagen content were investigated.
33730559	8	25	with	Correlations	1109:1120	arg1	GAGs					1164:1167	GAGs	1164:1167	GAGs	1164:1167	Correlations of moduli with water, glycosaminoglycans (GAGs), and collagen content were investigated.
33730559	8	25	with	Correlations	1109:1120	arg1	glycosaminoglycans					1144:1161	glycosaminoglycans	1144:1161	glycosaminoglycans (GAGs)	1144:1168	Correlations of moduli with water, glycosaminoglycans (GAGs), and collagen content were investigated.
33730559	0	26	theme	Viscoelastic	0:11	arg1	properties					35:44	Viscoelastic and equilibrium shear properties	0:44	properties	35:44	Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition.
33730559	11	27	theme	axial	1689:1693	arg1	~15 kPa					1701:1707	the axial plane ~15 kPa	1685:1707	the axial plane ~15 kPa	1685:1707	Circumferential samples, with collagen fibers orthogonal to the shear plane, exhibited superior dynamic mechanical properties, with G' ~70 kPa and G″ ~10 kPa, compared to those of the axial plane ~15 kPa and ~1 kPa, respectively.
33730559	10	28	theme	water	1386:1390	arg1	content					1392:1398	meniscal water content	1377:1398	meniscal water content	1377:1398	Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples).
33730559	6	29	dep	axial	907:911	arg1	planes					948:953	anatomical planes	937:953	anatomical planes	937:953	Specimens were prepared from the axial and the circumferential anatomical planes of medial and lateral menisci.
33730559	8	30	theme	collagen	1175:1182	arg1	content					1184:1190	collagen content	1175:1190	collagen content	1175:1190	Correlations of moduli with water, glycosaminoglycans (GAGs), and collagen content were investigated.
33730559	0	31	theme	shear	29:33	arg1	properties					35:44	Viscoelastic and equilibrium shear properties	0:44	properties	35:44	Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition.
33730559	5	32	theme	shear	792:796	arg1	properties					798:807	the dynamic and equilibrium shear properties	764:807	properties	798:807	Hence, the objective of this study was to characterize the dynamic and equilibrium shear properties of human meniscus in relation to its anisotropy and composition.
33730559	10	33	theme	shear	1265:1269	arg1	properties					1271:1280	Dynamic shear properties	1257:1280	Dynamic shear properties	1257:1280	Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples).
33730559	5	34	theme	human	812:816	arg1	meniscus					818:825	human meniscus	812:825	human meniscus	812:825	Hence, the objective of this study was to characterize the dynamic and equilibrium shear properties of human meniscus in relation to its anisotropy and composition.
33730559	0	35	theme	equilibrium	17:27	arg1	properties					35:44	Viscoelastic and equilibrium shear properties	0:44	properties	35:44	Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition.
33730559	4	36	theme	injury	572:577	arg1	mechanisms					549:558	mechanisms	549:558	mechanisms of meniscal injury	549:577	This is crucial to understand mechanisms of meniscal injury, as well as, in regenerative medicine, for the design and development of tissue engineered scaffolds mimicking the native tissue.
33730559	11	37	with	samples	1521:1527	arg1	fibers					1544:1549	collagen fibers	1535:1549	collagen fibers orthogonal to the shear plane	1535:1579	Circumferential samples, with collagen fibers orthogonal to the shear plane, exhibited superior dynamic mechanical properties, with G' ~70 kPa and G″ ~10 kPa, compared to those of the axial plane ~15 kPa and ~1 kPa, respectively.
33730559	10	38	from	GAG	1453:1455	arg1	samples					1495:1501	circumferential samples	1479:1501	circumferential samples	1479:1501	Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples).
33730559	2	39	theme	menisci	306:312	arg1	properties					286:295	the mechanical properties	271:295	the mechanical properties of human menisci	271:312	Although most of the mechanical properties of human menisci have been characterized, to our knowledge, its dynamic shear properties have never been reported.
33730559	10	40	theme	Dynamic	1257:1263	arg1	properties					1271:1280	Dynamic shear properties	1257:1280	Dynamic shear properties	1257:1280	Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples).
33730559	4	41	theme	scaffolds	670:678	arg1	development					637:647	development	637:647	development	637:647	This is crucial to understand mechanisms of meniscal injury, as well as, in regenerative medicine, for the design and development of tissue engineered scaffolds mimicking the native tissue.
33730559	4	41	theme	scaffolds	670:678	arg1	design					626:631	design	626:631	design	626:631	This is crucial to understand mechanisms of meniscal injury, as well as, in regenerative medicine, for the design and development of tissue engineered scaffolds mimicking the native tissue.
33730559	4	42	theme	meniscal	563:570	arg1	injury					572:577	meniscal injury	563:577	meniscal injury	563:577	This is crucial to understand mechanisms of meniscal injury, as well as, in regenerative medicine, for the design and development of tissue engineered scaffolds mimicking the native tissue.
33730559	1	43	theme	secondary	205:213	arg1	osteoarthritis					238:251	osteoarthritis	238:251	osteoarthritis	238:251	The meniscus is crucial in maintaining the knee function and protecting the joint from secondary pathologies, including osteoarthritis.
33730559	1	43	theme	secondary	205:213	arg1	pathologies					215:225	secondary pathologies	205:225	secondary pathologies	205:225	The meniscus is crucial in maintaining the knee function and protecting the joint from secondary pathologies, including osteoarthritis.
33730559	4	44	dep	design	626:631	arg1	the					622:624	the	622:624	the	622:624	This is crucial to understand mechanisms of meniscal injury, as well as, in regenerative medicine, for the design and development of tissue engineered scaffolds mimicking the native tissue.
33730559	3	45	theme	meniscal	444:451	arg1	properties					459:468	meniscal shear properties	444:468	meniscal shear properties in relation to tissue structure and composition	444:516	Moreover, little is known about meniscal shear properties in relation to tissue structure and composition.
33730559	6	46	theme	anatomical	937:946	arg1	planes					948:953	anatomical planes	937:953	anatomical planes	937:953	Specimens were prepared from the axial and the circumferential anatomical planes of medial and lateral menisci.
33730559	10	47	from	collagen	1461:1468	arg1	samples					1495:1501	circumferential samples	1479:1501	circumferential samples	1479:1501	Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples).
33730559	7	48	theme	stress	1007:1012	arg1	tests					1025:1029	stress relaxation tests	1007:1029	stress relaxation tests	1007:1029	Frequency sweeps and stress relaxation tests yielded storage (G') and loss moduli (G″), and equilibrium shear modulus (G).
33730559	3	49	theme	shear	453:457	arg1	properties					459:468	meniscal shear properties	444:468	meniscal shear properties in relation to tissue structure and composition	444:516	Moreover, little is known about meniscal shear properties in relation to tissue structure and composition.
33730559	0	50	theme	meniscus	55:62	arg1	properties					35:44	Viscoelastic and equilibrium shear properties	0:44	properties	35:44	Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition.
33730559	12	51	theme	G	1782:1782	arg1	values					1772:1777	the values	1768:1777	the values of G, which ranged from ~50 to ~100 kPa	1768:1817	Fiber orientation did not affect the values of G, which ranged from ~50 to ~100 kPa.
33730559	6	52	theme	medial	958:963	arg1	menisci					977:983	medial and lateral menisci	958:983	medial and lateral menisci	958:983	Specimens were prepared from the axial and the circumferential anatomical planes of medial and lateral menisci.
33730559	1	53	from	pathologies	215:225	arg1	joint					194:198	the joint	190:198	the joint from secondary pathologies, including osteoarthritis	190:251	The meniscus is crucial in maintaining the knee function and protecting the joint from secondary pathologies, including osteoarthritis.
33730559	3	54	theme	tissue	485:490	arg1	structure					492:500	tissue structure	485:500	tissue structure	485:500	Moreover, little is known about meniscal shear properties in relation to tissue structure and composition.
33730559	0	55	theme	human	49:53	arg1	meniscus					55:62	human meniscus	49:62	human meniscus	49:62	Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition.
33730559	0	56	dep	properties	35:44	arg1	Relationships					65:77	Relationships	65:77	Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition.	0:116	Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition.
33730559	3	57	from	properties	459:468	arg1	relation					473:480	relation	473:480	relation to tissue structure and composition	473:516	Moreover, little is known about meniscal shear properties in relation to tissue structure and composition.
33730559	4	58	theme	native	694:699	arg1	tissue					701:706	the native tissue	690:706	the native tissue	690:706	This is crucial to understand mechanisms of meniscal injury, as well as, in regenerative medicine, for the design and development of tissue engineered scaffolds mimicking the native tissue.
33730559	11	59	theme	collagen	1535:1542	arg1	fibers					1544:1549	collagen fibers	1535:1549	collagen fibers orthogonal to the shear plane	1535:1579	Circumferential samples, with collagen fibers orthogonal to the shear plane, exhibited superior dynamic mechanical properties, with G' ~70 kPa and G″ ~10 kPa, compared to those of the axial plane ~15 kPa and ~1 kPa, respectively.
33730559	11	60	theme	superior	1592:1599	arg1	properties					1620:1629	superior dynamic mechanical properties	1592:1629	superior dynamic mechanical properties	1592:1629	Circumferential samples, with collagen fibers orthogonal to the shear plane, exhibited superior dynamic mechanical properties, with G' ~70 kPa and G″ ~10 kPa, compared to those of the axial plane ~15 kPa and ~1 kPa, respectively.
33730559	11	61	theme	G″	1652:1653	arg1	~10 kPa					1655:1661	G″ ~10 kPa	1652:1661	G″ ~10 kPa	1652:1661	Circumferential samples, with collagen fibers orthogonal to the shear plane, exhibited superior dynamic mechanical properties, with G' ~70 kPa and G″ ~10 kPa, compared to those of the axial plane ~15 kPa and ~1 kPa, respectively.
33730559	4	62	dep	engineered	659:668	arg1	tissue					652:657	tissue	652:657	tissue	652:657	This is crucial to understand mechanisms of meniscal injury, as well as, in regenerative medicine, for the design and development of tissue engineered scaffolds mimicking the native tissue.
33730559	8	63	theme	moduli	1125:1130	arg1	Correlations					1109:1120	Correlations	1109:1120	Correlations of moduli with water, glycosaminoglycans (GAGs), and collagen content	1109:1190	Correlations of moduli with water, glycosaminoglycans (GAGs), and collagen content were investigated.
33730559	4	64	theme	engineered	659:668	arg1	scaffolds					670:678	tissue engineered scaffolds	652:678	tissue engineered scaffolds mimicking the native tissue	652:706	This is crucial to understand mechanisms of meniscal injury, as well as, in regenerative medicine, for the design and development of tissue engineered scaffolds mimicking the native tissue.
33730559	10	65	theme	tissue	1298:1303	arg1	composition					1305:1315	tissue composition	1298:1315	tissue composition	1298:1315	Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples).
33730559	10	66	theme	negative	1318:1325	arg1	correlations					1327:1338	negative correlations	1318:1338	negative correlations	1318:1338	Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples).
33730559	7	67	theme	Frequency	986:994	arg1	sweeps					996:1001	Frequency sweeps	986:1001	Frequency sweeps	986:1001	Frequency sweeps and stress relaxation tests yielded storage (G') and loss moduli (G″), and equilibrium shear modulus (G).
33730559	2	68	theme	shear	369:373	arg1	properties					375:384	its dynamic shear properties	357:384	its dynamic shear properties	357:384	Although most of the mechanical properties of human menisci have been characterized, to our knowledge, its dynamic shear properties have never been reported.
33730559	11	69	theme	plane	1695:1699	arg1	~15 kPa					1701:1707	the axial plane ~15 kPa	1685:1707	the axial plane ~15 kPa	1685:1707	Circumferential samples, with collagen fibers orthogonal to the shear plane, exhibited superior dynamic mechanical properties, with G' ~70 kPa and G″ ~10 kPa, compared to those of the axial plane ~15 kPa and ~1 kPa, respectively.
33730559	5	70	theme	study	738:742	arg1	objective					720:728	the objective	716:728	the objective of this study	716:742	Hence, the objective of this study was to characterize the dynamic and equilibrium shear properties of human meniscus in relation to its anisotropy and composition.
33730559	5	71	from	dynamic	768:774	arg1	relation					830:837	relation	830:837	relation to its anisotropy and composition	830:871	Hence, the objective of this study was to characterize the dynamic and equilibrium shear properties of human meniscus in relation to its anisotropy and composition.
33730559	2	72	theme	dynamic	361:367	arg1	properties					375:384	its dynamic shear properties	357:384	its dynamic shear properties	357:384	Although most of the mechanical properties of human menisci have been characterized, to our knowledge, its dynamic shear properties have never been reported.
33730559	11	73	theme	dynamic	1601:1607	arg1	properties					1620:1629	superior dynamic mechanical properties	1592:1629	superior dynamic mechanical properties	1592:1629	Circumferential samples, with collagen fibers orthogonal to the shear plane, exhibited superior dynamic mechanical properties, with G' ~70 kPa and G″ ~10 kPa, compared to those of the axial plane ~15 kPa and ~1 kPa, respectively.
33730559	4	74	theme	regenerative	595:606	arg1	medicine					608:615	regenerative medicine	595:615	regenerative medicine	595:615	This is crucial to understand mechanisms of meniscal injury, as well as, in regenerative medicine, for the design and development of tissue engineered scaffolds mimicking the native tissue.
32846404	8	0	theme	validated	1081:1089	arg1	method					1091:1096	the validated method	1077:1096	the validated method	1077:1096	Finally, the validated method was applied to the determination of zopiclone enantiomers in the commercial tablets.
32846404	6	1	theme	21 ng	962:966	arg1	mL-1					968:971	21 ng mL-1	962:971	21 ng mL-1	962:971	The limits of detection and quantification for (R)-zopiclone were 5 and 15 ng mL-1 and for (S)-zopiclone were 7 and 21 ng mL-1, respectively.
32846404	4	2	theme	acid	701:704	arg1	addition					664:671	small addition	658:671	small addition of triethylamine and acetic acid with a flow rate of 1 mL min-1	658:735	The mobile phase consisted of acetonitril and methanol with small addition of triethylamine and acetic acid with a flow rate of 1 mL min-1.
32846404	1	3	theme	rapid	158:162	arg1	method					176:181	New, sensitive and rapid chiral HPLC method	139:181	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone,	139:262	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone, was developed.
32846404	7	4	theme	proposed	1017:1024	arg1	selective					1037:1045	selective	1037:1045	selective	1037:1045	It was demonstrated that the proposed method was selective, precise and robust.
32846404	7	4	theme	proposed	1017:1024	arg1	method					1026:1031	the proposed method	1013:1031	the proposed method	1013:1031	It was demonstrated that the proposed method was selective, precise and robust.
32846404	0	5	from	separation	17:26	arg1	phase					89:93	immobilized polysaccharide chiral stationary phase	44:93	immobilized polysaccharide chiral stationary phase	44:93	Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC: Method development and validation.
32846404	1	6	theme	chiral	164:169	arg1	method					176:181	New, sensitive and rapid chiral HPLC method	139:181	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone,	139:262	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone, was developed.
32846404	2	7	theme	Lux	343:345	arg1	column					359:364	the immobilized amylose based Lux i-Amylose 1 column	313:364	the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min	313:405	Enantioseparation was achieved on the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min.
32846404	3	8	from	effects	412:418	arg1	enantioseparation					561:577	enantioseparation	561:577	enantioseparation	561:577	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	3	8	from	effects	412:418	arg1	retention					547:555	retention	547:555	retention	547:555	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	3	9	theme	column	521:526	arg1	temperature					528:538	column temperature	521:538	column temperature	521:538	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	4	10	theme	small	658:662	arg1	addition					664:671	small addition	658:671	small addition of triethylamine and acetic acid with a flow rate of 1 mL min-1	658:735	The mobile phase consisted of acetonitril and methanol with small addition of triethylamine and acetic acid with a flow rate of 1 mL min-1.
32846404	4	11	theme	1 mL	726:729	arg1	min-1					731:735	1 mL min-1	726:735	1 mL min-1	726:735	The mobile phase consisted of acetonitril and methanol with small addition of triethylamine and acetic acid with a flow rate of 1 mL min-1.
32846404	6	12	theme	R	894:894	arg1	-zopiclone					896:905	(R)-zopiclone	893:905	(R)-zopiclone	893:905	The limits of detection and quantification for (R)-zopiclone were 5 and 15 ng mL-1 and for (S)-zopiclone were 7 and 21 ng mL-1, respectively.
32846404	3	13	dep	retention	547:555	arg1	the					543:545	the	543:545	the	543:545	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	4	14	theme	flow	713:716	arg1	rate					718:721	a flow rate	711:721	a flow rate of 1 mL min-1	711:735	The mobile phase consisted of acetonitril and methanol with small addition of triethylamine and acetic acid with a flow rate of 1 mL min-1.
32846404	4	15	theme	acetic	694:699	arg1	acid					701:704	acetic acid	694:704	acetic acid	694:704	The mobile phase consisted of acetonitril and methanol with small addition of triethylamine and acetic acid with a flow rate of 1 mL min-1.
32846404	5	16	theme	5-125 μg	831:838	arg1	mL-1					840:843	5-125 μg mL-1	831:843	5-125 μg mL-1	831:843	Calibration curves of both zopiclone enantiomers were linear over the concentration range of 5-125 μg mL-1.
32846404	0	17	dep	Method	104:109	arg1	validation					127:136	validation	127:136	validation	127:136	Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC: Method development and validation.
32846404	0	17	dep	Method	104:109	arg1	development					111:121	development	111:121	development	111:121	Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC: Method development and validation.
32846404	0	17	dep	Method	104:109	arg1	separation					17:26	Enantioselective separation	0:26	Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC	0:101	Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC: Method development and validation.
32846404	1	18	theme	HPLC	171:174	arg1	method					176:181	New, sensitive and rapid chiral HPLC method	139:181	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone,	139:262	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone, was developed.
32846404	6	19	theme	quantification	874:887	arg1	limits					850:855	The limits	846:855	The limits of detection and quantification for (R)-zopiclone	846:905	The limits of detection and quantification for (R)-zopiclone were 5 and 15 ng mL-1 and for (S)-zopiclone were 7 and 21 ng mL-1, respectively.
32846404	6	19	theme	quantification	874:887	arg1	5					912:912	5	912:912	5	912:912	The limits of detection and quantification for (R)-zopiclone were 5 and 15 ng mL-1 and for (S)-zopiclone were 7 and 21 ng mL-1, respectively.
32846404	5	20	theme	zopiclone	765:773	arg1	enantiomers					775:785	both zopiclone enantiomers	760:785	both zopiclone enantiomers	760:785	Calibration curves of both zopiclone enantiomers were linear over the concentration range of 5-125 μg mL-1.
32846404	4	21	theme	mobile	602:607	arg1	phase					609:613	The mobile phase	598:613	The mobile phase	598:613	The mobile phase consisted of acetonitril and methanol with small addition of triethylamine and acetic acid with a flow rate of 1 mL min-1.
32846404	3	22	theme	phase	434:438	arg1	composition					440:450	the mobile phase composition	423:450	the mobile phase composition	423:450	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	3	23	theme	acid/base	501:509	arg1	ratio					511:515	acid/base ratio	501:515	acid/base ratio	501:515	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	2	24	from	column	359:364	arg1	mode					383:386	polar organic mode	369:386	polar organic mode in less than 7 min	369:405	Enantioseparation was achieved on the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min.
32846404	2	25	theme	amylose	329:335	arg1	column					359:364	the immobilized amylose based Lux i-Amylose 1 column	313:364	the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min	313:405	Enantioseparation was achieved on the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min.
32846404	0	26	theme	Enantioselective	0:15	arg1	separation					17:26	Enantioselective separation	0:26	Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC	0:101	Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC: Method development and validation.
32846404	6	27	theme	S	938:938	arg1	-zopiclone					940:949	(S)-zopiclone	937:949	(S)-zopiclone	937:949	The limits of detection and quantification for (R)-zopiclone were 5 and 15 ng mL-1 and for (S)-zopiclone were 7 and 21 ng mL-1, respectively.
32846404	2	28	theme	immobilized	317:327	arg1	column					359:364	the immobilized amylose based Lux i-Amylose 1 column	313:364	the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min	313:405	Enantioseparation was achieved on the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min.
32846404	0	29	theme	zopiclone	31:39	arg1	separation					17:26	Enantioselective separation	0:26	Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC	0:101	Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC: Method development and validation.
32846404	5	30	theme	mL-1	840:843	arg1	range					822:826	the concentration range	804:826	the concentration range of 5-125 μg mL-1	804:843	Calibration curves of both zopiclone enantiomers were linear over the concentration range of 5-125 μg mL-1.
32846404	8	31	theme	zopiclone	1134:1142	arg1	enantiomers					1144:1154	zopiclone enantiomers	1134:1154	zopiclone enantiomers	1134:1154	Finally, the validated method was applied to the determination of zopiclone enantiomers in the commercial tablets.
32846404	3	32	theme	type	453:456	arg1	effects					412:418	The effects	408:418	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation	408:577	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	3	33	theme	ratio	511:515	arg1	content					462:468	content	462:468	content	462:468	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	3	33	theme	ratio	511:515	arg1	type					453:456	type	453:456	type	453:456	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	3	33	theme	ratio	511:515	arg1	composition					440:450	the mobile phase composition	423:450	the mobile phase composition	423:450	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	6	34	theme	detection	860:868	arg1	limits					850:855	The limits	846:855	The limits of detection and quantification for (R)-zopiclone	846:905	The limits of detection and quantification for (R)-zopiclone were 5 and 15 ng mL-1 and for (S)-zopiclone were 7 and 21 ng mL-1, respectively.
32846404	6	34	theme	detection	860:868	arg1	5					912:912	5	912:912	5	912:912	The limits of detection and quantification for (R)-zopiclone were 5 and 15 ng mL-1 and for (S)-zopiclone were 7 and 21 ng mL-1, respectively.
32846404	4	35	theme	min-1	731:735	arg1	rate					718:721	a flow rate	711:721	a flow rate of 1 mL min-1	711:735	The mobile phase consisted of acetonitril and methanol with small addition of triethylamine and acetic acid with a flow rate of 1 mL min-1.
32846404	2	36	theme	organic	375:381	arg1	mode					383:386	polar organic mode	369:386	polar organic mode in less than 7 min	369:405	Enantioseparation was achieved on the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min.
32846404	0	37	theme	immobilized	44:54	arg1	phase					89:93	immobilized polysaccharide chiral stationary phase	44:93	immobilized polysaccharide chiral stationary phase	44:93	Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC: Method development and validation.
32846404	3	38	theme	components	479:488	arg1	content					462:468	content	462:468	content	462:468	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	3	38	theme	components	479:488	arg1	type					453:456	type	453:456	type	453:456	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	3	38	theme	components	479:488	arg1	composition					440:450	the mobile phase composition	423:450	the mobile phase composition	423:450	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	4	39	with	addition	664:671	arg1	rate					718:721	a flow rate	711:721	a flow rate of 1 mL min-1	711:735	The mobile phase consisted of acetonitril and methanol with small addition of triethylamine and acetic acid with a flow rate of 1 mL min-1.
32846404	3	40	theme	composition	440:450	arg1	effects					412:418	The effects	408:418	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation	408:577	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	3	41	theme	mobile	427:432	arg1	phase					434:438	the mobile phase	423:438	the mobile phase composition	423:450	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	5	42	theme	enantiomers	775:785	arg1	curves					750:755	Calibration curves	738:755	Calibration curves of both zopiclone enantiomers	738:785	Calibration curves of both zopiclone enantiomers were linear over the concentration range of 5-125 μg mL-1.
32846404	5	43	theme	concentration	808:820	arg1	range					822:826	the concentration range	804:826	the concentration range of 5-125 μg mL-1	804:843	Calibration curves of both zopiclone enantiomers were linear over the concentration range of 5-125 μg mL-1.
32846404	0	44	theme	chiral	71:76	arg1	phase					89:93	immobilized polysaccharide chiral stationary phase	44:93	immobilized polysaccharide chiral stationary phase	44:93	Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC: Method development and validation.
32846404	6	45	theme	15 ng	918:922	arg1	mL-1					924:927	15 ng mL-1	918:927	15 ng mL-1	918:927	The limits of detection and quantification for (R)-zopiclone were 5 and 15 ng mL-1 and for (S)-zopiclone were 7 and 21 ng mL-1, respectively.
32846404	8	46	theme	enantiomers	1144:1154	arg1	determination					1117:1129	the determination	1113:1129	the determination of zopiclone enantiomers in the commercial tablets	1113:1180	Finally, the validated method was applied to the determination of zopiclone enantiomers in the commercial tablets.
32846404	2	47	from	mode	383:386	arg1	less					391:394	less	391:394	less	391:394	Enantioseparation was achieved on the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min.
32846404	3	48	theme	major	473:477	arg1	components					479:488	major components	473:488	major components as well as acid/base ratio and column temperature	473:538	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	0	49	theme	polysaccharide	56:69	arg1	phase					89:93	immobilized polysaccharide chiral stationary phase	44:93	immobilized polysaccharide chiral stationary phase	44:93	Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC: Method development and validation.
32846404	3	50	theme	content	462:468	arg1	effects					412:418	The effects	408:418	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation	408:577	The effects of the mobile phase composition, type and content of major components as well as acid/base ratio and column temperature on the retention and enantioseparation were investigated.
32846404	8	51	from	determination	1117:1129	arg1	tablets					1174:1180	the commercial tablets	1159:1180	the commercial tablets	1159:1180	Finally, the validated method was applied to the determination of zopiclone enantiomers in the commercial tablets.
32846404	2	52	theme	i-Amylose	347:355	arg1	column					359:364	the immobilized amylose based Lux i-Amylose 1 column	313:364	the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min	313:405	Enantioseparation was achieved on the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min.
32846404	4	53	theme	triethylamine	676:688	arg1	addition					664:671	small addition	658:671	small addition of triethylamine and acetic acid with a flow rate of 1 mL min-1	658:735	The mobile phase consisted of acetonitril and methanol with small addition of triethylamine and acetic acid with a flow rate of 1 mL min-1.
32846404	1	54	theme	New	139:141	arg1	method					176:181	New, sensitive and rapid chiral HPLC method	139:181	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone,	139:262	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone, was developed.
32846404	1	55	theme	used	233:236	arg1	drug					247:250	widely used hypnotic drug	226:250	widely used hypnotic drug	226:250	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone, was developed.
32846404	1	55	theme	used	233:236	arg1	zopiclone					253:261	zopiclone	253:261	zopiclone	253:261	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone, was developed.
32846404	2	56	theme	based	337:341	arg1	column					359:364	the immobilized amylose based Lux i-Amylose 1 column	313:364	the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min	313:405	Enantioseparation was achieved on the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min.
32846404	8	57	theme	commercial	1163:1172	arg1	tablets					1174:1180	the commercial tablets	1159:1180	the commercial tablets	1159:1180	Finally, the validated method was applied to the determination of zopiclone enantiomers in the commercial tablets.
32846404	1	58	theme	hypnotic	238:245	arg1	drug					247:250	widely used hypnotic drug	226:250	widely used hypnotic drug	226:250	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone, was developed.
32846404	1	58	theme	hypnotic	238:245	arg1	zopiclone					253:261	zopiclone	253:261	zopiclone	253:261	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone, was developed.
32846404	5	59	theme	Calibration	738:748	arg1	curves					750:755	Calibration curves	738:755	Calibration curves of both zopiclone enantiomers	738:785	Calibration curves of both zopiclone enantiomers were linear over the concentration range of 5-125 μg mL-1.
32846404	1	60	theme	sensitive	144:152	arg1	method					176:181	New, sensitive and rapid chiral HPLC method	139:181	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone,	139:262	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone, was developed.
32846404	1	61	theme	drug	247:250	arg1	determination					209:221	determination	209:221	determination	209:221	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone, was developed.
32846404	1	61	theme	drug	247:250	arg1	enantioseparation					187:203	enantioseparation	187:203	enantioseparation	187:203	New, sensitive and rapid chiral HPLC method for enantioseparation and determination of widely used hypnotic drug, zopiclone, was developed.
32846404	0	62	theme	stationary	78:87	arg1	phase					89:93	immobilized polysaccharide chiral stationary phase	44:93	immobilized polysaccharide chiral stationary phase	44:93	Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC: Method development and validation.
32846404	2	63	theme	polar	369:373	arg1	mode					383:386	polar organic mode	369:386	polar organic mode in less than 7 min	369:405	Enantioseparation was achieved on the immobilized amylose based Lux i-Amylose 1 column in polar organic mode in less than 7 min.
33862131	0	0	theme	hydrogel	89:96	arg1	formation					113:121	in situ hydrogel wound dressing formation	81:121	in situ hydrogel wound dressing formation	81:121	Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation.
33862131	1	1	theme	antioxidant	242:252	arg1	activities					254:263	the anti-inflammatory and antioxidant activities	216:263	the anti-inflammatory and antioxidant activities	216:263	18β-glycyrrhetinic acid (Gly), a natural compound obtained from licorice, is known both for the anti-inflammatory and antioxidant activities and for this reason useful for wound treatment.
33862131	8	2	dep	MP	1075:1076	arg1	able					1120:1123	able	1120:1123	able	1120:1123	Ex vivo studies showed these MP maintain high swelling capability and are able to form in situ a hydrogel for wound repair.
33862131	8	2	dep	MP	1075:1076	arg1	maintain					1078:1085	maintain	1078:1085	maintain high swelling capability	1078:1110	Ex vivo studies showed these MP maintain high swelling capability and are able to form in situ a hydrogel for wound repair.
33862131	9	3	from	hydrogel	1209:1216	arg1	release					1185:1191	The controlled release	1170:1191	The controlled release of Gly from the hydrogel	1170:1216	The controlled release of Gly from the hydrogel stimulates keratinocyte growth, potentially supporting the physiological healing processes.
33862131	1	4	theme	natural	157:163	arg1	compound					165:172	a natural compound	155:172	a natural compound obtained from licorice	155:195	18β-glycyrrhetinic acid (Gly), a natural compound obtained from licorice, is known both for the anti-inflammatory and antioxidant activities and for this reason useful for wound treatment.
33862131	1	4	theme	natural	157:163	arg1	acid					143:146	18β-glycyrrhetinic acid	124:146	18β-glycyrrhetinic acid (Gly)	124:152	18β-glycyrrhetinic acid (Gly), a natural compound obtained from licorice, is known both for the anti-inflammatory and antioxidant activities and for this reason useful for wound treatment.
33862131	0	5	theme	dressing	104:111	arg1	formation					113:121	in situ hydrogel wound dressing formation	81:121	in situ hydrogel wound dressing formation	81:121	Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation.
33862131	4	6	theme	copolymer	785:793	arg1	SL					806:807	SL	806:807	SL	806:807	The MP were prepared by spray drying method from the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL).
33862131	4	6	theme	copolymer	785:793	arg1	Soluplus®					795:803	copolymer Soluplus®	785:803	copolymer Soluplus® (SL)	785:808	The MP were prepared by spray drying method from the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL).
33862131	0	7	theme	wound	98:102	arg1	formation					113:121	in situ hydrogel wound dressing formation	81:121	in situ hydrogel wound dressing formation	81:121	Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation.
33862131	5	8	theme	3:1	861:863	arg1	ratio					865:869	a 3:1 ratio	859:869	a 3:1 ratio (CMC/SL wt	859:880	Soluplus® introduction in MP composition, using a 3:1 ratio (CMC/SL wt.
33862131	9	9	theme	physiological	1277:1289	arg1	processes					1299:1307	the physiological healing processes	1273:1307	the physiological healing processes	1273:1307	The controlled release of Gly from the hydrogel stimulates keratinocyte growth, potentially supporting the physiological healing processes.
33862131	5	10	dep	ratio	865:869	arg1	wt					879:880	CMC/SL wt	872:880	a 3:1 ratio (CMC/SL wt	859:880	Soluplus® introduction in MP composition, using a 3:1 ratio (CMC/SL wt.
33862131	4	11	theme	carboxymethyl	751:763	arg1	cellulose					765:773	polysaccharide sodium carboxymethyl cellulose	729:773	polysaccharide sodium carboxymethyl cellulose (CMC)	729:779	The MP were prepared by spray drying method from the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL).
33862131	4	11	theme	carboxymethyl	751:763	arg1	CMC					776:778	CMC	776:778	CMC	776:778	The MP were prepared by spray drying method from the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL).
33862131	4	12	theme	spray	678:682	arg1	method					691:696	spray drying method	678:696	spray drying method	678:696	The MP were prepared by spray drying method from the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL).
33862131	8	13	theme	swelling	1092:1099	arg1	capability					1101:1110	high swelling capability	1087:1110	high swelling capability	1087:1110	Ex vivo studies showed these MP maintain high swelling capability and are able to form in situ a hydrogel for wound repair.
33862131	4	14	theme	sodium	744:749	arg1	cellulose					765:773	polysaccharide sodium carboxymethyl cellulose	729:773	polysaccharide sodium carboxymethyl cellulose (CMC)	729:779	The MP were prepared by spray drying method from the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL).
33862131	4	14	theme	sodium	744:749	arg1	CMC					776:778	CMC	776:778	CMC	776:778	The MP were prepared by spray drying method from the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL).
33862131	5	15	from	introduction	821:832	arg1	composition					840:850	MP composition	837:850	MP composition	837:850	Soluplus® introduction in MP composition, using a 3:1 ratio (CMC/SL wt.
33862131	8	16	theme	high	1087:1090	arg1	capability					1101:1110	high swelling capability	1087:1110	high swelling capability	1087:1110	Ex vivo studies showed these MP maintain high swelling capability and are able to form in situ a hydrogel for wound repair.
33862131	7	17	theme	MP	1031:1032	arg1	morphology					1034:1043	rugged surface MP morphology	1016:1043	rugged surface MP morphology	1016:1043	, allowed to stabilize Gly in non-crystalline form, favoring the improvement of water solubility, and to obtain a spherical with rugged surface MP morphology.
33862131	5	18	theme	MP	837:838	arg1	composition					840:850	MP composition	837:850	MP composition	837:850	Soluplus® introduction in MP composition, using a 3:1 ratio (CMC/SL wt.
33862131	4	19	theme	cellulose	765:773	arg1	solution					717:724	the polymeric solution	703:724	the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL)	703:808	The MP were prepared by spray drying method from the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL).
33862131	0	20	theme	carboxymethyl	22:34	arg1	cellulose					36:44	sodium carboxymethyl cellulose	15:44	sodium carboxymethyl cellulose	15:44	Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation.
33862131	9	21	theme	controlled	1174:1183	arg1	release					1185:1191	The controlled release	1170:1191	The controlled release of Gly from the hydrogel	1170:1216	The controlled release of Gly from the hydrogel stimulates keratinocyte growth, potentially supporting the physiological healing processes.
33862131	9	22	theme	healing	1291:1297	arg1	processes					1299:1307	the physiological healing processes	1273:1307	the physiological healing processes	1273:1307	The controlled release of Gly from the hydrogel stimulates keratinocyte growth, potentially supporting the physiological healing processes.
33862131	0	23	dep	in	81:82	arg1	situ					84:87	situ	84:87	situ	84:87	Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation.
33862131	3	24	with	contact	576:582	arg1	exudate					593:599	the exudate	589:599	the exudate	589:599	Polymeric bioadhesive microparticles (MP), loaded with Gly, were developed to be introduced in the wound bed and swell, once in contact with the exudate, to form a hydrogel in situ able to close the wound.
33862131	0	25	theme	sodium	15:20	arg1	cellulose					36:44	sodium carboxymethyl cellulose	15:44	sodium carboxymethyl cellulose	15:44	Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation.
33862131	1	26	theme	useful	285:290	arg1	reason					278:283	this reason	273:283	this reason useful for wound treatment	273:310	18β-glycyrrhetinic acid (Gly), a natural compound obtained from licorice, is known both for the anti-inflammatory and antioxidant activities and for this reason useful for wound treatment.
33862131	7	27	with	spherical	1001:1009	arg1	morphology					1034:1043	rugged surface MP morphology	1016:1043	rugged surface MP morphology	1016:1043	, allowed to stabilize Gly in non-crystalline form, favoring the improvement of water solubility, and to obtain a spherical with rugged surface MP morphology.
33862131	2	28	theme	topical	399:405	arg1	gels					424:427	gels	424:427	gels	424:427	Due to its poor solubility, Gly is not suitable for formulations used in conventional topical products such as gels, foams and creams.
33862131	2	28	theme	topical	399:405	arg1	creams					440:445	creams	440:445	creams	440:445	Due to its poor solubility, Gly is not suitable for formulations used in conventional topical products such as gels, foams and creams.
33862131	2	28	theme	topical	399:405	arg1	foams					430:434	foams	430:434	foams	430:434	Due to its poor solubility, Gly is not suitable for formulations used in conventional topical products such as gels, foams and creams.
33862131	2	28	theme	topical	399:405	arg1	products					407:414	conventional topical products	386:414	conventional topical products such as gels, foams and creams	386:445	Due to its poor solubility, Gly is not suitable for formulations used in conventional topical products such as gels, foams and creams.
33862131	7	29	theme	non-crystalline	917:931	arg1	form					933:936	non-crystalline form	917:936	non-crystalline form	917:936	, allowed to stabilize Gly in non-crystalline form, favoring the improvement of water solubility, and to obtain a spherical with rugged surface MP morphology.
33862131	3	30	theme	wound	547:551	arg1	bed					553:555	the wound bed	543:555	the wound bed	543:555	Polymeric bioadhesive microparticles (MP), loaded with Gly, were developed to be introduced in the wound bed and swell, once in contact with the exudate, to form a hydrogel in situ able to close the wound.
33862131	2	31	theme	conventional	386:397	arg1	gels					424:427	gels	424:427	gels	424:427	Due to its poor solubility, Gly is not suitable for formulations used in conventional topical products such as gels, foams and creams.
33862131	2	31	theme	conventional	386:397	arg1	creams					440:445	creams	440:445	creams	440:445	Due to its poor solubility, Gly is not suitable for formulations used in conventional topical products such as gels, foams and creams.
33862131	2	31	theme	conventional	386:397	arg1	foams					430:434	foams	430:434	foams	430:434	Due to its poor solubility, Gly is not suitable for formulations used in conventional topical products such as gels, foams and creams.
33862131	2	31	theme	conventional	386:397	arg1	products					407:414	conventional topical products	386:414	conventional topical products such as gels, foams and creams	386:445	Due to its poor solubility, Gly is not suitable for formulations used in conventional topical products such as gels, foams and creams.
33862131	0	32	theme	cellulose	36:44	arg1	Development					0:10	Development	0:10	Development of sodium carboxymethyl cellulose	0:44	Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation.
33862131	1	33	theme	wound	296:300	arg1	treatment					302:310	wound treatment	296:310	wound treatment	296:310	18β-glycyrrhetinic acid (Gly), a natural compound obtained from licorice, is known both for the anti-inflammatory and antioxidant activities and for this reason useful for wound treatment.
33862131	4	34	theme	polymeric	707:715	arg1	solution					717:724	the polymeric solution	703:724	the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL)	703:808	The MP were prepared by spray drying method from the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL).
33862131	9	35	theme	Gly	1196:1198	arg1	release					1185:1191	The controlled release	1170:1191	The controlled release of Gly from the hydrogel	1170:1216	The controlled release of Gly from the hydrogel stimulates keratinocyte growth, potentially supporting the physiological healing processes.
33862131	4	36	theme	polysaccharide	729:742	arg1	cellulose					765:773	polysaccharide sodium carboxymethyl cellulose	729:773	polysaccharide sodium carboxymethyl cellulose (CMC)	729:779	The MP were prepared by spray drying method from the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL).
33862131	4	36	theme	polysaccharide	729:742	arg1	CMC					776:778	CMC	776:778	CMC	776:778	The MP were prepared by spray drying method from the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL).
33862131	1	37	theme	18β-glycyrrhetinic	124:141	arg1	compound					165:172	a natural compound	155:172	a natural compound obtained from licorice	155:195	18β-glycyrrhetinic acid (Gly), a natural compound obtained from licorice, is known both for the anti-inflammatory and antioxidant activities and for this reason useful for wound treatment.
33862131	1	37	theme	18β-glycyrrhetinic	124:141	arg1	Gly					149:151	Gly	149:151	Gly	149:151	18β-glycyrrhetinic acid (Gly), a natural compound obtained from licorice, is known both for the anti-inflammatory and antioxidant activities and for this reason useful for wound treatment.
33862131	1	37	theme	18β-glycyrrhetinic	124:141	arg1	acid					143:146	18β-glycyrrhetinic acid	124:146	18β-glycyrrhetinic acid (Gly)	124:152	18β-glycyrrhetinic acid (Gly), a natural compound obtained from licorice, is known both for the anti-inflammatory and antioxidant activities and for this reason useful for wound treatment.
33862131	0	38	theme	polymeric	52:60	arg1	microparticles					62:75	polymeric microparticles	52:75	polymeric microparticles for in situ hydrogel wound dressing formation	52:121	Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation.
33862131	4	39	theme	Soluplus®	795:803	arg1	solution					717:724	the polymeric solution	703:724	the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL)	703:808	The MP were prepared by spray drying method from the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL).
33862131	7	40	theme	water	967:971	arg1	solubility					973:982	water solubility	967:982	water solubility	967:982	, allowed to stabilize Gly in non-crystalline form, favoring the improvement of water solubility, and to obtain a spherical with rugged surface MP morphology.
33862131	2	41	theme	poor	324:327	arg1	solubility					329:338	its poor solubility	320:338	its poor solubility	320:338	Due to its poor solubility, Gly is not suitable for formulations used in conventional topical products such as gels, foams and creams.
33862131	7	42	theme	rugged	1016:1021	arg1	morphology					1034:1043	rugged surface MP morphology	1016:1043	rugged surface MP morphology	1016:1043	, allowed to stabilize Gly in non-crystalline form, favoring the improvement of water solubility, and to obtain a spherical with rugged surface MP morphology.
33862131	8	43	dep	Ex	1046:1047	arg1	vivo					1049:1052	vivo	1049:1052	vivo	1049:1052	Ex vivo studies showed these MP maintain high swelling capability and are able to form in situ a hydrogel for wound repair.
33862131	5	44	theme	CMC/SL	872:877	arg1	wt					879:880	CMC/SL wt	872:880	a 3:1 ratio (CMC/SL wt	859:880	Soluplus® introduction in MP composition, using a 3:1 ratio (CMC/SL wt.
33862131	3	45	theme	Polymeric	448:456	arg1	microparticles					470:483	Polymeric bioadhesive microparticles	448:483	Polymeric bioadhesive microparticles (MP)	448:488	Polymeric bioadhesive microparticles (MP), loaded with Gly, were developed to be introduced in the wound bed and swell, once in contact with the exudate, to form a hydrogel in situ able to close the wound.
33862131	3	45	theme	Polymeric	448:456	arg1	MP					486:487	MP	486:487	MP	486:487	Polymeric bioadhesive microparticles (MP), loaded with Gly, were developed to be introduced in the wound bed and swell, once in contact with the exudate, to form a hydrogel in situ able to close the wound.
33862131	4	46	theme	drying	684:689	arg1	method					691:696	spray drying method	678:696	spray drying method	678:696	The MP were prepared by spray drying method from the polymeric solution of polysaccharide sodium carboxymethyl cellulose (CMC) and copolymer Soluplus® (SL).
33862131	7	47	theme	solubility	973:982	arg1	improvement					952:962	the improvement	948:962	the improvement of water solubility	948:982	, allowed to stabilize Gly in non-crystalline form, favoring the improvement of water solubility, and to obtain a spherical with rugged surface MP morphology.
33862131	3	48	theme	bioadhesive	458:468	arg1	microparticles					470:483	Polymeric bioadhesive microparticles	448:483	Polymeric bioadhesive microparticles (MP)	448:488	Polymeric bioadhesive microparticles (MP), loaded with Gly, were developed to be introduced in the wound bed and swell, once in contact with the exudate, to form a hydrogel in situ able to close the wound.
33862131	3	48	theme	bioadhesive	458:468	arg1	MP					486:487	MP	486:487	MP	486:487	Polymeric bioadhesive microparticles (MP), loaded with Gly, were developed to be introduced in the wound bed and swell, once in contact with the exudate, to form a hydrogel in situ able to close the wound.
33862131	9	49	theme	keratinocyte	1229:1240	arg1	growth					1242:1247	keratinocyte growth	1229:1247	keratinocyte growth	1229:1247	The controlled release of Gly from the hydrogel stimulates keratinocyte growth, potentially supporting the physiological healing processes.
33862131	0	50	theme	in	81:82	arg1	formation					113:121	in situ hydrogel wound dressing formation	81:121	in situ hydrogel wound dressing formation	81:121	Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation.
33862131	8	51	theme	wound	1156:1160	arg1	repair					1162:1167	wound repair	1156:1167	wound repair	1156:1167	Ex vivo studies showed these MP maintain high swelling capability and are able to form in situ a hydrogel for wound repair.
33862131	1	52	theme	anti-inflammatory	220:236	arg1	activities					254:263	the anti-inflammatory and antioxidant activities	216:263	the anti-inflammatory and antioxidant activities	216:263	18β-glycyrrhetinic acid (Gly), a natural compound obtained from licorice, is known both for the anti-inflammatory and antioxidant activities and for this reason useful for wound treatment.
33862131	7	53	theme	surface	1023:1029	arg1	morphology					1034:1043	rugged surface MP morphology	1016:1043	rugged surface MP morphology	1016:1043	, allowed to stabilize Gly in non-crystalline form, favoring the improvement of water solubility, and to obtain a spherical with rugged surface MP morphology.
33862131	8	54	theme	Ex	1046:1047	arg1	studies					1054:1060	Ex vivo studies	1046:1060	Ex vivo studies	1046:1060	Ex vivo studies showed these MP maintain high swelling capability and are able to form in situ a hydrogel for wound repair.
34705611	1	0	theme	animal	195:200	arg1	gut					202:204	the animal gut	191:204	the animal gut	191:204	Understanding how exogenous microbes stably colonize the animal gut is essential to reveal mechanisms of action and tailor effective probiotic treatments.
34705611	6	1	theme	persistence	848:858	arg1	levels					828:833	high levels	823:833	high levels of B.p. MP80 persistence	823:858	2'FL supplementation creates a niche for high levels of B.p. MP80 persistence, similar to Bifidobacterium levels seen in breast-fed infants.
34705611	6	2	theme	breast-fed	903:912	arg1	infants					914:920	breast-fed infants	903:920	breast-fed infants	903:920	2'FL supplementation creates a niche for high levels of B.p. MP80 persistence, similar to Bifidobacterium levels seen in breast-fed infants.
34705611	8	3	theme	promotion	1278:1286	arg1	mechanisms					1257:1266	mechanisms	1257:1266	mechanisms of health promotion by bifidobacteriain neonates	1257:1315	These results demonstrate that bacterial-milk glycan interactions alone drive enrichment of beneficial Bifidobacterium and provide a model for tunable colonization thus facilitating insight into mechanisms of health promotion by bifidobacteriain neonates.
34705611	7	4	theme	chemically-induced	1034:1051	arg1	colitis					1053:1059	chemically-induced colitis	1034:1059	chemically-induced colitis	1034:1059	This synergism impacted gut microbiota composition, activated anti-inflammatory pathways and protected against chemically-induced colitis.
34705611	6	5	theme	MP80	843:846	arg1	persistence					848:858	B.p. MP80 persistence	838:858	B.p. MP80 persistence	838:858	2'FL supplementation creates a niche for high levels of B.p. MP80 persistence, similar to Bifidobacterium levels seen in breast-fed infants.
34705611	8	6	theme	health	1271:1276	arg1	promotion					1278:1286	health promotion	1271:1286	health promotion by bifidobacteriain neonates	1271:1315	These results demonstrate that bacterial-milk glycan interactions alone drive enrichment of beneficial Bifidobacterium and provide a model for tunable colonization thus facilitating insight into mechanisms of health promotion by bifidobacteriain neonates.
34705611	6	7	theme	B.p.	838:841	arg1	persistence					848:858	B.p. MP80 persistence	838:858	B.p. MP80 persistence	838:858	2'FL supplementation creates a niche for high levels of B.p. MP80 persistence, similar to Bifidobacterium levels seen in breast-fed infants.
34705611	8	8	theme	bifidobacteriain	1291:1306	arg1	neonates					1308:1315	bifidobacteriain neonates	1291:1315	bifidobacteriain neonates	1291:1315	These results demonstrate that bacterial-milk glycan interactions alone drive enrichment of beneficial Bifidobacterium and provide a model for tunable colonization thus facilitating insight into mechanisms of health promotion by bifidobacteriain neonates.
34705611	8	9	theme	beneficial	1154:1163	arg1	Bifidobacterium					1165:1179	beneficial Bifidobacterium	1154:1179	beneficial Bifidobacterium	1154:1179	These results demonstrate that bacterial-milk glycan interactions alone drive enrichment of beneficial Bifidobacterium and provide a model for tunable colonization thus facilitating insight into mechanisms of health promotion by bifidobacteriain neonates.
34705611	5	10	theme	HMO	675:677	arg1	fucosyllactose					681:694	the HMO 2'fucosyllactose	671:694	the HMO 2'fucosyllactose (2'FL)	671:701	This study examined mice supplemented with the HMO 2'fucosyllactose (2'FL) together with a 2'FL-consuming strain, Bifidobacterium pseudocatenulatum MP80.
34705611	5	10	theme	HMO	675:677	arg1	FL					699:700	2'FL	697:700	2'FL	697:700	This study examined mice supplemented with the HMO 2'fucosyllactose (2'FL) together with a 2'FL-consuming strain, Bifidobacterium pseudocatenulatum MP80.
34705611	4	11	from	colonization	533:544	arg1	proof					493:497	direct mechanistic proof	474:497	direct mechanistic proof of the importance of HMOs in this colonization	474:544	However, direct mechanistic proof of the importance of HMOs in this colonization is lacking given milk contains additional factors that impact the gut microbiota.
34705611	7	12	theme	anti-inflammatory	985:1001	arg1	pathways					1003:1010	anti-inflammatory pathways	985:1010	anti-inflammatory pathways	985:1010	This synergism impacted gut microbiota composition, activated anti-inflammatory pathways and protected against chemically-induced colitis.
34705611	6	13	theme	high	823:826	arg1	levels					828:833	high levels	823:833	high levels of B.p. MP80 persistence	823:858	2'FL supplementation creates a niche for high levels of B.p. MP80 persistence, similar to Bifidobacterium levels seen in breast-fed infants.
34705611	2	14	theme	breast-fed	373:382	arg1	infants					384:390	breast-fed infants	373:390	breast-fed infants	373:390	Bifidobacterium species are naturally enriched in the gastrointestinal tract of breast-fed infants.
34705611	4	15	from	proof	493:497	arg1	colonization					533:544	this colonization	528:544	this colonization	528:544	However, direct mechanistic proof of the importance of HMOs in this colonization is lacking given milk contains additional factors that impact the gut microbiota.
34705611	5	16	theme	Bifidobacterium	742:756	arg1	strain					734:739	a 2'FL-consuming strain	717:739	a 2'FL-consuming strain	717:739	This study examined mice supplemented with the HMO 2'fucosyllactose (2'FL) together with a 2'FL-consuming strain, Bifidobacterium pseudocatenulatum MP80.
34705611	5	16	theme	Bifidobacterium	742:756	arg1	pseudocatenulatum					758:774	Bifidobacterium pseudocatenulatum MP80	742:779	Bifidobacterium pseudocatenulatum MP80	742:779	This study examined mice supplemented with the HMO 2'fucosyllactose (2'FL) together with a 2'FL-consuming strain, Bifidobacterium pseudocatenulatum MP80.
34705611	0	17	theme	Bifidobacterium	0:14	arg1	catabolism					16:25	Bifidobacterium catabolism	0:25	Bifidobacterium catabolism of human milk oligosaccharides	0:56	Bifidobacterium catabolism of human milk oligosaccharides overrides endogenous competitive exclusion driving colonization and protection.
34705611	4	18	theme	gut	612:614	arg1	microbiota					616:625	the gut microbiota	608:625	the gut microbiota	608:625	However, direct mechanistic proof of the importance of HMOs in this colonization is lacking given milk contains additional factors that impact the gut microbiota.
34705611	8	19	theme	Bifidobacterium	1165:1179	arg1	enrichment					1140:1149	enrichment	1140:1149	enrichment of beneficial Bifidobacterium	1140:1179	These results demonstrate that bacterial-milk glycan interactions alone drive enrichment of beneficial Bifidobacterium and provide a model for tunable colonization thus facilitating insight into mechanisms of health promotion by bifidobacteriain neonates.
34705611	8	20	theme	glycan	1108:1113	arg1	interactions					1115:1126	bacterial-milk glycan interactions	1093:1126	bacterial-milk glycan interactions	1093:1126	These results demonstrate that bacterial-milk glycan interactions alone drive enrichment of beneficial Bifidobacterium and provide a model for tunable colonization thus facilitating insight into mechanisms of health promotion by bifidobacteriain neonates.
34705611	6	21	theme	Bifidobacterium	872:886	arg1	levels					888:893	Bifidobacterium levels	872:893	Bifidobacterium levels seen in breast-fed infants	872:920	2'FL supplementation creates a niche for high levels of B.p. MP80 persistence, similar to Bifidobacterium levels seen in breast-fed infants.
34705611	0	22	theme	human	30:34	arg1	oligosaccharides					41:56	human milk oligosaccharides	30:56	human milk oligosaccharides	30:56	Bifidobacterium catabolism of human milk oligosaccharides overrides endogenous competitive exclusion driving colonization and protection.
34705611	8	23	theme	bacterial-milk	1093:1106	arg1	interactions					1115:1126	bacterial-milk glycan interactions	1093:1126	bacterial-milk glycan interactions	1093:1126	These results demonstrate that bacterial-milk glycan interactions alone drive enrichment of beneficial Bifidobacterium and provide a model for tunable colonization thus facilitating insight into mechanisms of health promotion by bifidobacteriain neonates.
34705611	4	24	theme	importance	506:515	arg1	proof					493:497	direct mechanistic proof	474:497	direct mechanistic proof of the importance of HMOs in this colonization	474:544	However, direct mechanistic proof of the importance of HMOs in this colonization is lacking given milk contains additional factors that impact the gut microbiota.
34705611	2	25	theme	gastrointestinal	347:362	arg1	tract					364:368	the gastrointestinal tract	343:368	the gastrointestinal tract of breast-fed infants	343:390	Bifidobacterium species are naturally enriched in the gastrointestinal tract of breast-fed infants.
34705611	0	26	theme	oligosaccharides	41:56	arg1	catabolism					16:25	Bifidobacterium catabolism	0:25	Bifidobacterium catabolism of human milk oligosaccharides	0:56	Bifidobacterium catabolism of human milk oligosaccharides overrides endogenous competitive exclusion driving colonization and protection.
34705611	4	27	from	importance	506:515	arg1	colonization					533:544	this colonization	528:544	this colonization	528:544	However, direct mechanistic proof of the importance of HMOs in this colonization is lacking given milk contains additional factors that impact the gut microbiota.
34705611	1	28	theme	action	243:248	arg1	mechanisms					229:238	mechanisms	229:238	mechanisms of action	229:248	Understanding how exogenous microbes stably colonize the animal gut is essential to reveal mechanisms of action and tailor effective probiotic treatments.
34705611	0	29	theme	milk	36:39	arg1	oligosaccharides					41:56	human milk oligosaccharides	30:56	human milk oligosaccharides	30:56	Bifidobacterium catabolism of human milk oligosaccharides overrides endogenous competitive exclusion driving colonization and protection.
34705611	4	30	theme	HMOs	520:523	arg1	importance					506:515	the importance	502:515	the importance of HMOs in this colonization	502:544	However, direct mechanistic proof of the importance of HMOs in this colonization is lacking given milk contains additional factors that impact the gut microbiota.
34705611	0	31	theme	endogenous	68:77	arg1	exclusion					91:99	endogenous competitive exclusion	68:99	endogenous competitive exclusion driving colonization and protection	68:135	Bifidobacterium catabolism of human milk oligosaccharides overrides endogenous competitive exclusion driving colonization and protection.
34705611	4	32	theme	additional	577:586	arg1	factors					588:594	additional factors	577:594	additional factors that impact the gut microbiota	577:625	However, direct mechanistic proof of the importance of HMOs in this colonization is lacking given milk contains additional factors that impact the gut microbiota.
34705611	0	33	theme	competitive	79:89	arg1	exclusion					91:99	endogenous competitive exclusion	68:99	endogenous competitive exclusion driving colonization and protection	68:135	Bifidobacterium catabolism of human milk oligosaccharides overrides endogenous competitive exclusion driving colonization and protection.
34705611	8	34	theme	tunable	1205:1211	arg1	colonization					1213:1224	tunable colonization	1205:1224	tunable colonization	1205:1224	These results demonstrate that bacterial-milk glycan interactions alone drive enrichment of beneficial Bifidobacterium and provide a model for tunable colonization thus facilitating insight into mechanisms of health promotion by bifidobacteriain neonates.
34705611	1	35	dep	Understanding	138:150	arg1	colonize					182:189	colonize	182:189	colonize the animal gut	182:204	Understanding how exogenous microbes stably colonize the animal gut is essential to reveal mechanisms of action and tailor effective probiotic treatments.
34705611	4	36	theme	mechanistic	481:491	arg1	proof					493:497	direct mechanistic proof	474:497	direct mechanistic proof of the importance of HMOs in this colonization	474:544	However, direct mechanistic proof of the importance of HMOs in this colonization is lacking given milk contains additional factors that impact the gut microbiota.
34705611	1	37	theme	exogenous	156:164	arg1	microbes					166:173	exogenous microbes	156:173	exogenous microbes	156:173	Understanding how exogenous microbes stably colonize the animal gut is essential to reveal mechanisms of action and tailor effective probiotic treatments.
34705611	7	38	theme	microbiota	951:960	arg1	composition					962:972	gut microbiota composition	947:972	gut microbiota composition	947:972	This synergism impacted gut microbiota composition, activated anti-inflammatory pathways and protected against chemically-induced colitis.
34705611	4	39	theme	direct	474:479	arg1	proof					493:497	direct mechanistic proof	474:497	direct mechanistic proof of the importance of HMOs in this colonization	474:544	However, direct mechanistic proof of the importance of HMOs in this colonization is lacking given milk contains additional factors that impact the gut microbiota.
34705611	6	40	theme	FL	784:785	arg1	supplementation					787:801	2'FL supplementation	782:801	2'FL supplementation	782:801	2'FL supplementation creates a niche for high levels of B.p. MP80 persistence, similar to Bifidobacterium levels seen in breast-fed infants.
34705611	5	41	theme	2'FL-consuming	719:732	arg1	strain					734:739	a 2'FL-consuming strain	717:739	a 2'FL-consuming strain	717:739	This study examined mice supplemented with the HMO 2'fucosyllactose (2'FL) together with a 2'FL-consuming strain, Bifidobacterium pseudocatenulatum MP80.
34705611	5	41	theme	2'FL-consuming	719:732	arg1	pseudocatenulatum					758:774	Bifidobacterium pseudocatenulatum MP80	742:779	Bifidobacterium pseudocatenulatum MP80	742:779	This study examined mice supplemented with the HMO 2'fucosyllactose (2'FL) together with a 2'FL-consuming strain, Bifidobacterium pseudocatenulatum MP80.
34705611	6	42	theme	similar	861:867	arg1	niche					813:817	a niche	811:817	a niche	811:817	2'FL supplementation creates a niche for high levels of B.p. MP80 persistence, similar to Bifidobacterium levels seen in breast-fed infants.
34705611	2	43	theme	infants	384:390	arg1	tract					364:368	the gastrointestinal tract	343:368	the gastrointestinal tract of breast-fed infants	343:390	Bifidobacterium species are naturally enriched in the gastrointestinal tract of breast-fed infants.
34705611	1	44	theme	effective	261:269	arg1	treatments					281:290	effective probiotic treatments	261:290	effective probiotic treatments	261:290	Understanding how exogenous microbes stably colonize the animal gut is essential to reveal mechanisms of action and tailor effective probiotic treatments.
34705611	3	45	theme	Human	393:397	arg1	HMOs					422:425	HMOs	422:425	HMOs	422:425	Human milk oligosaccharides (HMOs) are associated with this enrichment.
34705611	3	45	theme	Human	393:397	arg1	oligosaccharides					404:419	Human milk oligosaccharides	393:419	Human milk oligosaccharides (HMOs)	393:426	Human milk oligosaccharides (HMOs) are associated with this enrichment.
34705611	2	46	theme	Bifidobacterium	293:307	arg1	species					309:315	Bifidobacterium species	293:315	Bifidobacterium species	293:315	Bifidobacterium species are naturally enriched in the gastrointestinal tract of breast-fed infants.
34705611	7	47	theme	gut	947:949	arg1	composition					962:972	gut microbiota composition	947:972	gut microbiota composition	947:972	This synergism impacted gut microbiota composition, activated anti-inflammatory pathways and protected against chemically-induced colitis.
34705611	1	48	theme	probiotic	271:279	arg1	treatments					281:290	effective probiotic treatments	261:290	effective probiotic treatments	261:290	Understanding how exogenous microbes stably colonize the animal gut is essential to reveal mechanisms of action and tailor effective probiotic treatments.
34705611	3	49	theme	milk	399:402	arg1	HMOs					422:425	HMOs	422:425	HMOs	422:425	Human milk oligosaccharides (HMOs) are associated with this enrichment.
34705611	3	49	theme	milk	399:402	arg1	oligosaccharides					404:419	Human milk oligosaccharides	393:419	Human milk oligosaccharides (HMOs)	393:426	Human milk oligosaccharides (HMOs) are associated with this enrichment.
34705611	4	50	contain	contains	568:575	arg1	milk					563:566	milk	563:566	milk	563:566	However, direct mechanistic proof of the importance of HMOs in this colonization is lacking given milk contains additional factors that impact the gut microbiota.
34705611	4	50	contain	contains	568:575	arg2	factors					588:594	additional factors	577:594	additional factors that impact the gut microbiota	577:625	However, direct mechanistic proof of the importance of HMOs in this colonization is lacking given milk contains additional factors that impact the gut microbiota.
35002236	1	0	theme	scaffolds	234:242	arg1	fabrication					219:229	the fabrication	215:229	the fabrication of scaffolds with personalized structures	215:271	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	11	1	theme	ideal	1779:1783	arg1	engineering					1797:1807	an ideal bone tissue engineering	1776:1807	an ideal bone tissue engineering material for the repair of bone defects	1776:1847	CONCLUSION These properties render the Gel/SA/nano-ATP composite hydrogel scaffolds an ideal bone tissue engineering material for the repair of bone defects.
35002236	1	2	theme	personalized	249:260	arg1	structures					262:271	personalized structures	249:271	personalized structures	249:271	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	1	3	theme	tissue	124:129	arg1	strategy					158:165	a new strategy	152:165	a new strategy for bone defect repair	152:188	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	1	3	theme	tissue	124:129	arg1	BTE					144:146	BTE	144:146	BTE	144:146	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	1	3	theme	tissue	124:129	arg1	engineering					131:141	INTRODUCTION Bone tissue engineering	106:141	INTRODUCTION Bone tissue engineering (BTE)	106:147	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	5	4	theme	marrow-derived	812:825	arg1	BMSCs					851:855	BMSCs	851:855	BMSCs	851:855	Furthermore, mouse bone marrow-derived mesenchymal stem cells (BMSCs) were cultured with the composite hydrogels in vitro, and proliferation and osteoblastic differentiation were assessed.
35002236	5	4	theme	marrow-derived	812:825	arg1	cells					844:848	mesenchymal stem cells	827:848	mouse bone marrow-derived mesenchymal stem cells (BMSCs)	801:856	Furthermore, mouse bone marrow-derived mesenchymal stem cells (BMSCs) were cultured with the composite hydrogels in vitro, and proliferation and osteoblastic differentiation were assessed.
35002236	9	5	theme	good	1488:1491	arg1	biocompatibility					1493:1508	good biocompatibility	1488:1508	good biocompatibility	1488:1508	The Gel/SA/nano-ATP composite hydrogel also showed good biocompatibility and promoted the osteogenesis of BMSCs.
35002236	3	6	theme	alginate	567:574	arg1	scaffolds					604:612	sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds	560:612	sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds	560:612	METHODS In this study, sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds doped with different contents of nano-attapulgite were fabricated via 3D printing.
35002236	1	7	theme	defect	176:181	arg1	repair					183:188	bone defect repair	171:188	bone defect repair	171:188	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	6	8	theme	rabbit	979:984	arg1	model					1007:1011	A rabbit tibia plateau defect model	977:1011	A rabbit tibia plateau defect model	977:1011	A rabbit tibia plateau defect model was used to evaluate the osteogenic potential of the composite hydrogel in vivo.
35002236	8	9	theme	significant	1310:1320	arg1	effect					1337:1342	a significant mineralization effect	1308:1342	a significant mineralization effect	1308:1342	Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days.
35002236	8	10	theme	composite	1254:1262	arg1	hydrogels					1264:1272	Gel/SA/nano-ATP composite hydrogels	1238:1272	Gel/SA/nano-ATP composite hydrogels	1238:1272	Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days.
35002236	7	11	dep	RESULTS	1094:1100	arg1	showed					1176:1181	showed	1176:1181	showed better mechanical property and printability	1176:1225	RESULTS When increasing nano-ATP content, the Gel/SA/nano-ATP composite hydrogels showed better mechanical property and printability.
35002236	9	12	theme	composite	1457:1465	arg1	hydrogel					1467:1474	The Gel/SA/nano-ATP composite hydrogel	1437:1474	The Gel/SA/nano-ATP composite hydrogel	1437:1474	The Gel/SA/nano-ATP composite hydrogel also showed good biocompatibility and promoted the osteogenesis of BMSCs.
35002236	5	13	theme	mesenchymal	827:837	arg1	BMSCs					851:855	BMSCs	851:855	BMSCs	851:855	Furthermore, mouse bone marrow-derived mesenchymal stem cells (BMSCs) were cultured with the composite hydrogels in vitro, and proliferation and osteoblastic differentiation were assessed.
35002236	5	13	theme	mesenchymal	827:837	arg1	cells					844:848	mesenchymal stem cells	827:848	mouse bone marrow-derived mesenchymal stem cells (BMSCs)	801:856	Furthermore, mouse bone marrow-derived mesenchymal stem cells (BMSCs) were cultured with the composite hydrogels in vitro, and proliferation and osteoblastic differentiation were assessed.
35002236	2	14	with	scaffolds	431:439	arg1	complexity					462:471	high structural complexity	446:471	high structural complexity	446:471	The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
35002236	3	15	theme	SA	577:578	arg1	scaffolds					604:612	sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds	560:612	sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds	560:612	METHODS In this study, sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds doped with different contents of nano-attapulgite were fabricated via 3D printing.
35002236	3	16	dep	METHODS	537:543	arg1	doped					614:618	doped	614:618	doped with different contents of nano-attapulgite	614:662	METHODS In this study, sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds doped with different contents of nano-attapulgite were fabricated via 3D printing.
35002236	2	17	dep	three-dimensional	341:357	arg1	3D					360:361	3D	360:361	3D	360:361	The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
35002236	3	18	theme	hydrogel	595:602	arg1	scaffolds					604:612	sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds	560:612	sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds	560:612	METHODS In this study, sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds doped with different contents of nano-attapulgite were fabricated via 3D printing.
35002236	11	19	theme	defects	1841:1847	arg1	repair					1826:1831	the repair	1822:1831	the repair of bone defects	1822:1847	CONCLUSION These properties render the Gel/SA/nano-ATP composite hydrogel scaffolds an ideal bone tissue engineering material for the repair of bone defects.
35002236	5	20	theme	stem	839:842	arg1	BMSCs					851:855	BMSCs	851:855	BMSCs	851:855	Furthermore, mouse bone marrow-derived mesenchymal stem cells (BMSCs) were cultured with the composite hydrogels in vitro, and proliferation and osteoblastic differentiation were assessed.
35002236	5	20	theme	stem	839:842	arg1	cells					844:848	mesenchymal stem cells	827:848	mouse bone marrow-derived mesenchymal stem cells (BMSCs)	801:856	Furthermore, mouse bone marrow-derived mesenchymal stem cells (BMSCs) were cultured with the composite hydrogels in vitro, and proliferation and osteoblastic differentiation were assessed.
35002236	0	21	theme	Bone	86:89	arg1	Repair					98:103	Bone Tissue Repair	86:103	Bone Tissue Repair	86:103	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds Doped with Nano-Attapulgite for Bone Tissue Repair.
35002236	1	22	theme	new	154:156	arg1	strategy					158:165	a new strategy	152:165	a new strategy for bone defect repair	152:188	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	1	22	theme	new	154:156	arg1	engineering					131:141	INTRODUCTION Bone tissue engineering	106:141	INTRODUCTION Bone tissue engineering (BTE)	106:147	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	2	23	theme	repair	529:534	arg1	specific					506:513	specific	506:513	specific	506:513	The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
35002236	8	24	theme	simulated	1397:1405	arg1	SBF					1419:1421	SBF	1419:1421	SBF	1419:1421	Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days.
35002236	8	24	theme	simulated	1397:1405	arg1	fluid					1412:1416	simulated body fluid	1397:1416	simulated body fluid (SBF)	1397:1422	Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days.
35002236	6	25	theme	plateau	992:998	arg1	model					1007:1011	A rabbit tibia plateau defect model	977:1011	A rabbit tibia plateau defect model	977:1011	A rabbit tibia plateau defect model was used to evaluate the osteogenic potential of the composite hydrogel in vivo.
35002236	2	26	theme	high	446:449	arg1	complexity					462:471	high structural complexity	446:471	high structural complexity	446:471	The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
35002236	0	27	theme	3D	0:1	arg1	Scaffolds					44:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds	0:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds	0:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds Doped with Nano-Attapulgite for Bone Tissue Repair.
35002236	6	28	theme	composite	1066:1074	arg1	hydrogel					1076:1083	the composite hydrogel	1062:1083	the composite hydrogel	1062:1083	A rabbit tibia plateau defect model was used to evaluate the osteogenic potential of the composite hydrogel in vivo.
35002236	2	29	theme	scaffolds	431:439	arg1	structures					417:426	the porous structures	406:426	the porous structures of scaffolds with high structural complexity	406:471	The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
35002236	4	30	theme	mechanical	744:753	arg1	properties					755:764	mechanical properties	744:764	mechanical properties	744:764	The surface microstructure, hydrophilicity and mechanical properties were fully evaluated.
35002236	0	31	theme	Gelatin/Sodium	11:24	arg1	Scaffolds					44:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds	0:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds	0:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds Doped with Nano-Attapulgite for Bone Tissue Repair.
35002236	8	32	located	observed	1348:1355	arg2	effect					1337:1342	a significant mineralization effect	1308:1342	a significant mineralization effect	1308:1342	Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days.
35002236	8	32	located	observed	1348:1355	arg1	surface					1364:1370	the surface	1360:1370	the surface	1360:1370	Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days.
35002236	1	33	theme	Bone	119:122	arg1	strategy					158:165	a new strategy	152:165	a new strategy for bone defect repair	152:188	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	1	33	theme	Bone	119:122	arg1	BTE					144:146	BTE	144:146	BTE	144:146	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	1	33	theme	Bone	119:122	arg1	engineering					131:141	INTRODUCTION Bone tissue engineering	106:141	INTRODUCTION Bone tissue engineering (BTE)	106:147	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	3	34	theme	different	625:633	arg1	contents					635:642	different contents	625:642	different contents of nano-attapulgite	625:662	METHODS In this study, sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds doped with different contents of nano-attapulgite were fabricated via 3D printing.
35002236	0	35	theme	Hydrogel	35:42	arg1	Scaffolds					44:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds	0:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds	0:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds Doped with Nano-Attapulgite for Bone Tissue Repair.
35002236	1	36	theme	clinical	293:300	arg1	applications					302:313	their clinical applications	287:313	their clinical applications	287:313	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	6	37	theme	osteogenic	1038:1047	arg1	potential					1049:1057	the osteogenic potential	1034:1057	the osteogenic potential of the composite hydrogel	1034:1083	A rabbit tibia plateau defect model was used to evaluate the osteogenic potential of the composite hydrogel in vivo.
35002236	2	38	theme	three-dimensional	341:357	arg1	printing					364:371	three-dimensional (3D) printing	341:371	three-dimensional (3D) printing	341:371	The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
35002236	7	39	theme	composite	1156:1164	arg1	hydrogels					1166:1174	the Gel/SA/nano-ATP composite hydrogels	1136:1174	the Gel/SA/nano-ATP composite hydrogels	1136:1174	RESULTS When increasing nano-ATP content, the Gel/SA/nano-ATP composite hydrogels showed better mechanical property and printability.
35002236	5	40	link	marrow-derived	812:825	arg1	BMSCs					851:855	BMSCs	851:855	BMSCs	851:855	Furthermore, mouse bone marrow-derived mesenchymal stem cells (BMSCs) were cultured with the composite hydrogels in vitro, and proliferation and osteoblastic differentiation were assessed.
35002236	5	40	link	marrow-derived	812:825	arg1	cells					844:848	mesenchymal stem cells	827:848	mouse bone marrow-derived mesenchymal stem cells (BMSCs)	801:856	Furthermore, mouse bone marrow-derived mesenchymal stem cells (BMSCs) were cultured with the composite hydrogels in vitro, and proliferation and osteoblastic differentiation were assessed.
35002236	11	41	theme	bone	1836:1839	arg1	defects					1841:1847	bone defects	1836:1847	bone defects	1836:1847	CONCLUSION These properties render the Gel/SA/nano-ATP composite hydrogel scaffolds an ideal bone tissue engineering material for the repair of bone defects.
35002236	10	42	theme	Gel/SA/nano-ATP	1603:1617	arg1	hydrogels					1629:1637	the Gel/SA/nano-ATP composite hydrogels	1599:1637	the Gel/SA/nano-ATP composite hydrogels	1599:1637	Finally, histological analysis demonstrates that the Gel/SA/nano-ATP composite hydrogels could effectively enhance bone regeneration in vivo.
35002236	9	43	theme	Gel/SA/nano-ATP	1441:1455	arg1	hydrogel					1467:1474	The Gel/SA/nano-ATP composite hydrogel	1437:1474	The Gel/SA/nano-ATP composite hydrogel	1437:1474	The Gel/SA/nano-ATP composite hydrogel also showed good biocompatibility and promoted the osteogenesis of BMSCs.
35002236	2	44	from	development	326:336	arg1	printing					364:371	three-dimensional (3D) printing	341:371	three-dimensional (3D) printing	341:371	The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
35002236	10	45	theme	bone	1665:1668	arg1	regeneration					1670:1681	bone regeneration	1665:1681	bone regeneration	1665:1681	Finally, histological analysis demonstrates that the Gel/SA/nano-ATP composite hydrogels could effectively enhance bone regeneration in vivo.
35002236	11	46	theme	Gel/SA/nano-ATP	1731:1745	arg1	hydrogel					1757:1764	the Gel/SA/nano-ATP composite hydrogel	1727:1764	the Gel/SA/nano-ATP composite hydrogel	1727:1764	CONCLUSION These properties render the Gel/SA/nano-ATP composite hydrogel scaffolds an ideal bone tissue engineering material for the repair of bone defects.
35002236	7	47	theme	nano-ATP	1118:1125	arg1	content					1127:1133	nano-ATP content	1118:1133	nano-ATP content	1118:1133	RESULTS When increasing nano-ATP content, the Gel/SA/nano-ATP composite hydrogels showed better mechanical property and printability.
35002236	11	48	theme	bone	1785:1788	arg1	engineering					1797:1807	an ideal bone tissue engineering	1776:1807	an ideal bone tissue engineering material for the repair of bone defects	1776:1847	CONCLUSION These properties render the Gel/SA/nano-ATP composite hydrogel scaffolds an ideal bone tissue engineering material for the repair of bone defects.
35002236	6	49	used	used	1017:1020	arg2	model					1007:1011	A rabbit tibia plateau defect model	977:1011	A rabbit tibia plateau defect model	977:1011	A rabbit tibia plateau defect model was used to evaluate the osteogenic potential of the composite hydrogel in vivo.
35002236	8	50	theme	excellent	1281:1289	arg1	bioactivity					1291:1301	excellent bioactivity	1281:1301	excellent bioactivity	1281:1301	Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days.
35002236	3	51	theme	sodium	560:565	arg1	scaffolds					604:612	sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds	560:612	sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds	560:612	METHODS In this study, sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds doped with different contents of nano-attapulgite were fabricated via 3D printing.
35002236	1	52	theme	bone	171:174	arg1	repair					183:188	bone defect repair	171:188	bone defect repair	171:188	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	6	53	theme	tibia	986:990	arg1	model					1007:1011	A rabbit tibia plateau defect model	977:1011	A rabbit tibia plateau defect model	977:1011	A rabbit tibia plateau defect model was used to evaluate the osteogenic potential of the composite hydrogel in vivo.
35002236	11	54	dep	CONCLUSION	1692:1701	arg1	render					1720:1725	render	1720:1725	render the Gel/SA/nano-ATP composite hydrogel scaffolds an ideal bone tissue engineering material for the repair of bone defects	1720:1847	CONCLUSION These properties render the Gel/SA/nano-ATP composite hydrogel scaffolds an ideal bone tissue engineering material for the repair of bone defects.
35002236	8	55	theme	Gel/SA/nano-ATP	1238:1252	arg1	hydrogels					1264:1272	Gel/SA/nano-ATP composite hydrogels	1238:1272	Gel/SA/nano-ATP composite hydrogels	1238:1272	Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days.
35002236	8	56	theme	mineralization	1322:1335	arg1	effect					1337:1342	a significant mineralization effect	1308:1342	a significant mineralization effect	1308:1342	Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days.
35002236	9	57	theme	BMSCs	1543:1547	arg1	osteogenesis					1527:1538	the osteogenesis	1523:1538	the osteogenesis of BMSCs	1523:1547	The Gel/SA/nano-ATP composite hydrogel also showed good biocompatibility and promoted the osteogenesis of BMSCs.
35002236	1	58	from	difficulties	199:210	arg1	fabrication					219:229	the fabrication	215:229	the fabrication of scaffolds with personalized structures	215:271	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	1	59	with	scaffolds	234:242	arg1	structures					262:271	personalized structures	249:271	personalized structures	249:271	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	4	60	theme	surface	701:707	arg1	microstructure					709:722	The surface microstructure	697:722	The surface microstructure	697:722	The surface microstructure, hydrophilicity and mechanical properties were fully evaluated.
35002236	5	61	theme	composite	881:889	arg1	hydrogels					891:899	the composite hydrogels	877:899	the composite hydrogels	877:899	Furthermore, mouse bone marrow-derived mesenchymal stem cells (BMSCs) were cultured with the composite hydrogels in vitro, and proliferation and osteoblastic differentiation were assessed.
35002236	0	62	theme	Tissue	91:96	arg1	Repair					98:103	Bone Tissue Repair	86:103	Bone Tissue Repair	86:103	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds Doped with Nano-Attapulgite for Bone Tissue Repair.
35002236	3	63	theme	Gel	590:592	arg1	scaffolds					604:612	sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds	560:612	sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds	560:612	METHODS In this study, sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds doped with different contents of nano-attapulgite were fabricated via 3D printing.
35002236	6	64	theme	defect	1000:1005	arg1	model					1007:1011	A rabbit tibia plateau defect model	977:1011	A rabbit tibia plateau defect model	977:1011	A rabbit tibia plateau defect model was used to evaluate the osteogenic potential of the composite hydrogel in vivo.
35002236	2	65	theme	bone	524:527	arg1	repair					529:534	bone repair	524:534	bone repair	524:534	The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
35002236	8	66	theme	body	1407:1410	arg1	SBF					1419:1421	SBF	1419:1421	SBF	1419:1421	Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days.
35002236	8	66	theme	body	1407:1410	arg1	fluid					1412:1416	simulated body fluid	1397:1416	simulated body fluid (SBF)	1397:1422	Moreover, Gel/SA/nano-ATP composite hydrogels showed excellent bioactivity, and a significant mineralization effect was observed on the surface after being incubated in simulated body fluid (SBF) for 14 days.
35002236	0	67	theme	Printed	3:9	arg1	Scaffolds					44:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds	0:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds	0:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds Doped with Nano-Attapulgite for Bone Tissue Repair.
35002236	5	68	theme	osteoblastic	933:944	arg1	differentiation					946:960	osteoblastic differentiation	933:960	osteoblastic differentiation	933:960	Furthermore, mouse bone marrow-derived mesenchymal stem cells (BMSCs) were cultured with the composite hydrogels in vitro, and proliferation and osteoblastic differentiation were assessed.
35002236	6	69	theme	hydrogel	1076:1083	arg1	potential					1049:1057	the osteogenic potential	1034:1057	the osteogenic potential of the composite hydrogel	1034:1083	A rabbit tibia plateau defect model was used to evaluate the osteogenic potential of the composite hydrogel in vivo.
35002236	0	70	theme	Alginate	26:33	arg1	Scaffolds					44:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds	0:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds	0:52	3D Printed Gelatin/Sodium Alginate Hydrogel Scaffolds Doped with Nano-Attapulgite for Bone Tissue Repair.
35002236	1	71	theme	INTRODUCTION	106:117	arg1	strategy					158:165	a new strategy	152:165	a new strategy for bone defect repair	152:188	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	1	71	theme	INTRODUCTION	106:117	arg1	BTE					144:146	BTE	144:146	BTE	144:146	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	1	71	theme	INTRODUCTION	106:117	arg1	engineering					131:141	INTRODUCTION Bone tissue engineering	106:141	INTRODUCTION Bone tissue engineering (BTE)	106:147	INTRODUCTION Bone tissue engineering (BTE) is a new strategy for bone defect repair, but the difficulties in the fabrication of scaffolds with personalized structures still limited their clinical applications.
35002236	11	72	theme	material	1809:1816	arg1	engineering					1797:1807	an ideal bone tissue engineering	1776:1807	an ideal bone tissue engineering material for the repair of bone defects	1776:1847	CONCLUSION These properties render the Gel/SA/nano-ATP composite hydrogel scaffolds an ideal bone tissue engineering material for the repair of bone defects.
35002236	2	73	theme	porous	410:415	arg1	structures					417:426	the porous structures	406:426	the porous structures of scaffolds with high structural complexity	406:471	The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
35002236	11	74	theme	tissue	1790:1795	arg1	engineering					1797:1807	an ideal bone tissue engineering	1776:1807	an ideal bone tissue engineering material for the repair of bone defects	1776:1847	CONCLUSION These properties render the Gel/SA/nano-ATP composite hydrogel scaffolds an ideal bone tissue engineering material for the repair of bone defects.
35002236	7	75	theme	Gel/SA/nano-ATP	1140:1154	arg1	hydrogels					1166:1174	the Gel/SA/nano-ATP composite hydrogels	1136:1174	the Gel/SA/nano-ATP composite hydrogels	1136:1174	RESULTS When increasing nano-ATP content, the Gel/SA/nano-ATP composite hydrogels showed better mechanical property and printability.
35002236	2	76	theme	structural	451:460	arg1	complexity					462:471	high structural complexity	446:471	high structural complexity	446:471	The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
35002236	3	77	theme	3D	684:685	arg1	printing					687:694	3D printing	684:694	3D printing	684:694	METHODS In this study, sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds doped with different contents of nano-attapulgite were fabricated via 3D printing.
35002236	3	78	theme	nano-attapulgite	647:662	arg1	contents					635:642	different contents	625:642	different contents of nano-attapulgite	625:662	METHODS In this study, sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds doped with different contents of nano-attapulgite were fabricated via 3D printing.
35002236	2	79	dep	specific	506:513	arg1	needs					515:519	needs	515:519	needs	515:519	The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
35002236	3	80	theme	/gelatin	580:587	arg1	scaffolds					604:612	sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds	560:612	sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds	560:612	METHODS In this study, sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds doped with different contents of nano-attapulgite were fabricated via 3D printing.
35002236	10	81	theme	histological	1559:1570	arg1	analysis					1572:1579	histological analysis	1559:1579	histological analysis	1559:1579	Finally, histological analysis demonstrates that the Gel/SA/nano-ATP composite hydrogels could effectively enhance bone regeneration in vivo.
35002236	2	82	theme	rapid	320:324	arg1	development					326:336	The rapid development	316:336	The rapid development in three-dimensional (3D) printing	316:371	The rapid development in three-dimensional (3D) printing endows it capable of controlling the porous structures of scaffolds with high structural complexity and provides flexibility to meet specific needs of bone repair.
35002236	10	83	theme	composite	1619:1627	arg1	hydrogels					1629:1637	the Gel/SA/nano-ATP composite hydrogels	1599:1637	the Gel/SA/nano-ATP composite hydrogels	1599:1637	Finally, histological analysis demonstrates that the Gel/SA/nano-ATP composite hydrogels could effectively enhance bone regeneration in vivo.
35002236	11	84	theme	composite	1747:1755	arg1	hydrogel					1757:1764	the Gel/SA/nano-ATP composite hydrogel	1727:1764	the Gel/SA/nano-ATP composite hydrogel	1727:1764	CONCLUSION These properties render the Gel/SA/nano-ATP composite hydrogel scaffolds an ideal bone tissue engineering material for the repair of bone defects.
35002236	7	85	theme	mechanical	1190:1199	arg1	property					1201:1208	property	1201:1208	property	1201:1208	RESULTS When increasing nano-ATP content, the Gel/SA/nano-ATP composite hydrogels showed better mechanical property and printability.
34015226	2	0	theme	synthesized	393:403	arg1	copolymers					405:414	synthesized copolymers	393:414	synthesized copolymers	393:414	Acrylamide grafting and carboxymethylation of A. chundra gum were carried out and synthesized copolymers were characterized.
34015226	1	1	theme	acrylamide-grafted	258:275	arg1	copolymers					299:308	its acrylamide-grafted and carboxymethylated copolymers	254:308	its acrylamide-grafted and carboxymethylated copolymers	254:308	Present communication deals with the stabilization of etoricoxib nanosuspension using Acacia chundra gum and its acrylamide-grafted and carboxymethylated copolymers.
34015226	0	2	dep	In	119:120	arg1	Vitro					122:126	Vitro	122:126	Vitro	122:126	Stabilization of Etoricoxib Nanosuspension Using Acacia chundra Gum and Copolymers: Preparation, Characterization, and In Vitro Cytotoxic Study.
34015226	4	3	theme	carboxymethylated	642:658	arg1	copolymers					677:686	carboxymethylated (formulation C1) copolymers	642:686	carboxymethylated (formulation C1) copolymers	642:686	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	1	4	theme	carboxymethylated	281:297	arg1	copolymers					299:308	its acrylamide-grafted and carboxymethylated copolymers	254:308	its acrylamide-grafted and carboxymethylated copolymers	254:308	Present communication deals with the stabilization of etoricoxib nanosuspension using Acacia chundra gum and its acrylamide-grafted and carboxymethylated copolymers.
34015226	4	5	theme	A.	568:569	arg1	gum					579:581	A 3 A. chundra gum	564:581	A 3 A. chundra gum (formulation K9)	564:598	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	4	5	theme	A.	568:569	arg1	K9					596:597	formulation K9	584:597	formulation K9	584:597	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	4	6	theme	nanosuspension	837:850	arg1	fabrication					811:821	the fabrication	807:821	the fabrication of stabilized nanosuspension	807:850	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	4	7	theme	formulation	661:671	arg1	copolymers					677:686	carboxymethylated (formulation C1) copolymers	642:686	carboxymethylated (formulation C1) copolymers	642:686	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	4	8	theme	A.	697:698	arg1	gum					708:710	t A. chundra gum	695:710	t A. chundra gum	695:710	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	2	9	theme	Acrylamide	311:320	arg1	grafting					322:329	Acrylamide grafting	311:329	Acrylamide grafting	311:329	Acrylamide grafting and carboxymethylation of A. chundra gum were carried out and synthesized copolymers were characterized.
34015226	3	10	theme	Ultrasound-assisted	436:454	arg1	method					476:481	Ultrasound-assisted solvent-antisolvent method	436:481	Ultrasound-assisted solvent-antisolvent method	436:481	Ultrasound-assisted solvent-antisolvent method was utilized to co-precipitate the stabilizers over etoricoxib nanoprecipitates.
34015226	4	11	theme	chundra	571:577	arg1	gum					579:581	A 3 A. chundra gum	564:581	A 3 A. chundra gum (formulation K9)	564:598	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	4	11	theme	chundra	571:577	arg1	K9					596:597	formulation K9	584:597	formulation K9	584:597	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	2	12	theme	chundra	360:366	arg1	gum					368:370	A. chundra gum	357:370	A. chundra gum	357:370	Acrylamide grafting and carboxymethylation of A. chundra gum were carried out and synthesized copolymers were characterized.
34015226	4	13	theme	carboxymethylated	735:751	arg1	copolymers					753:762	its acrylamide and carboxymethylated copolymers	716:762	copolymers	753:762	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	3	14	theme	solvent-antisolvent	456:474	arg1	method					476:481	Ultrasound-assisted solvent-antisolvent method	436:481	Ultrasound-assisted solvent-antisolvent method	436:481	Ultrasound-assisted solvent-antisolvent method was utilized to co-precipitate the stabilizers over etoricoxib nanoprecipitates.
34015226	2	15	theme	A.	357:358	arg1	gum					368:370	A. chundra gum	357:370	A. chundra gum	357:370	Acrylamide grafting and carboxymethylation of A. chundra gum were carried out and synthesized copolymers were characterized.
34015226	0	16	theme	Nanosuspension	28:41	arg1	Stabilization					0:12	Stabilization	0:12	Stabilization of Etoricoxib Nanosuspension Using Acacia chundra Gum and Copolymers: Preparation, Characterization, and In Vitro Cytotoxic Study.	0:143	Stabilization of Etoricoxib Nanosuspension Using Acacia chundra Gum and Copolymers: Preparation, Characterization, and In Vitro Cytotoxic Study.
34015226	4	17	theme	stabilized	826:835	arg1	nanosuspension					837:850	stabilized nanosuspension	826:850	stabilized nanosuspension	826:850	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	1	18	theme	etoricoxib	199:208	arg1	nanosuspension					210:223	etoricoxib nanosuspension	199:223	etoricoxib nanosuspension using Acacia chundra gum and its acrylamide-grafted and carboxymethylated copolymers	199:308	Present communication deals with the stabilization of etoricoxib nanosuspension using Acacia chundra gum and its acrylamide-grafted and carboxymethylated copolymers.
34015226	0	19	theme	In	119:120	arg1	Study					138:142	In Vitro Cytotoxic Study	119:142	In Vitro Cytotoxic Study	119:142	Stabilization of Etoricoxib Nanosuspension Using Acacia chundra Gum and Copolymers: Preparation, Characterization, and In Vitro Cytotoxic Study.
34015226	1	20	theme	nanosuspension	210:223	arg1	stabilization					182:194	the stabilization	178:194	the stabilization of etoricoxib nanosuspension using Acacia chundra gum and its acrylamide-grafted and carboxymethylated copolymers	178:308	Present communication deals with the stabilization of etoricoxib nanosuspension using Acacia chundra gum and its acrylamide-grafted and carboxymethylated copolymers.
34015226	0	21	theme	Acacia	49:54	arg1	Gum					64:66	Acacia chundra Gum	49:66	Acacia chundra Gum	49:66	Stabilization of Etoricoxib Nanosuspension Using Acacia chundra Gum and Copolymers: Preparation, Characterization, and In Vitro Cytotoxic Study.
34015226	3	22	theme	etoricoxib	535:544	arg1	nanoprecipitates					546:561	etoricoxib nanoprecipitates	535:561	etoricoxib nanoprecipitates	535:561	Ultrasound-assisted solvent-antisolvent method was utilized to co-precipitate the stabilizers over etoricoxib nanoprecipitates.
34015226	0	23	theme	Cytotoxic	128:136	arg1	Study					138:142	In Vitro Cytotoxic Study	119:142	In Vitro Cytotoxic Study	119:142	Stabilization of Etoricoxib Nanosuspension Using Acacia chundra Gum and Copolymers: Preparation, Characterization, and In Vitro Cytotoxic Study.
34015226	1	24	theme	Acacia	231:236	arg1	gum					246:248	Acacia chundra gum	231:248	Acacia chundra gum	231:248	Present communication deals with the stabilization of etoricoxib nanosuspension using Acacia chundra gum and its acrylamide-grafted and carboxymethylated copolymers.
34015226	0	25	theme	chundra	56:62	arg1	Gum					64:66	Acacia chundra Gum	49:66	Acacia chundra Gum	49:66	Stabilization of Etoricoxib Nanosuspension Using Acacia chundra Gum and Copolymers: Preparation, Characterization, and In Vitro Cytotoxic Study.
34015226	4	26	theme	formulation	621:631	arg1	acrylamide-grafted					601:618	acrylamide-grafted	601:618	acrylamide-grafted	601:618	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	4	26	theme	formulation	621:631	arg1	A8					633:634	formulation A8	621:634	formulation A8	621:634	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	4	27	dep	A.	697:698	arg1	chundra					700:706	chundra	700:706	chundra	700:706	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	1	28	theme	chundra	238:244	arg1	gum					246:248	Acacia chundra gum	231:248	Acacia chundra gum	231:248	Present communication deals with the stabilization of etoricoxib nanosuspension using Acacia chundra gum and its acrylamide-grafted and carboxymethylated copolymers.
34015226	3	29	used	utilized	487:494	arg2	method					476:481	Ultrasound-assisted solvent-antisolvent method	436:481	Ultrasound-assisted solvent-antisolvent method	436:481	Ultrasound-assisted solvent-antisolvent method was utilized to co-precipitate the stabilizers over etoricoxib nanoprecipitates.
34015226	2	30	theme	gum	368:370	arg1	grafting					322:329	Acrylamide grafting	311:329	Acrylamide grafting	311:329	Acrylamide grafting and carboxymethylation of A. chundra gum were carried out and synthesized copolymers were characterized.
34015226	2	30	theme	gum	368:370	arg1	carboxymethylation					335:352	carboxymethylation	335:352	carboxymethylation	335:352	Acrylamide grafting and carboxymethylation of A. chundra gum were carried out and synthesized copolymers were characterized.
34015226	4	31	dep	acrylamide	720:729	arg1	utilized					794:801	utilized	794:801	utilized for the fabrication of stabilized nanosuspension	794:850	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	4	31	dep	acrylamide	720:729	arg1	synthesized					778:788	synthesized	778:788	synthesized	778:788	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	4	32	theme	t	695:695	arg1	gum					708:710	t A. chundra gum	695:710	t A. chundra gum	695:710	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	4	33	theme	C1	673:674	arg1	copolymers					677:686	carboxymethylated (formulation C1) copolymers	642:686	carboxymethylated (formulation C1) copolymers	642:686	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	4	34	theme	formulation	584:594	arg1	gum					579:581	A 3 A. chundra gum	564:581	A 3 A. chundra gum (formulation K9)	564:598	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	4	34	theme	formulation	584:594	arg1	K9					596:597	formulation K9	584:597	formulation K9	584:597	A 3 A. chundra gum (formulation K9), acrylamide-grafted (formulation A8), and carboxymethylated (formulation C1) copolymers showed t A. chundra gum and its acrylamide and carboxymethylated copolymers can be easily synthesized and utilized for the fabrication of stabilized nanosuspension.
34015226	0	35	dep	Stabilization	0:12	arg1	Characterization					97:112	Characterization	97:112	Characterization	97:112	Stabilization of Etoricoxib Nanosuspension Using Acacia chundra Gum and Copolymers: Preparation, Characterization, and In Vitro Cytotoxic Study.
34015226	0	35	dep	Stabilization	0:12	arg1	Study					138:142	In Vitro Cytotoxic Study	119:142	In Vitro Cytotoxic Study	119:142	Stabilization of Etoricoxib Nanosuspension Using Acacia chundra Gum and Copolymers: Preparation, Characterization, and In Vitro Cytotoxic Study.
34015226	0	35	dep	Stabilization	0:12	arg1	Preparation					84:94	Preparation	84:94	Preparation	84:94	Stabilization of Etoricoxib Nanosuspension Using Acacia chundra Gum and Copolymers: Preparation, Characterization, and In Vitro Cytotoxic Study.
34015226	1	36	theme	Present	145:151	arg1	communication					153:165	Present communication	145:165	Present communication	145:165	Present communication deals with the stabilization of etoricoxib nanosuspension using Acacia chundra gum and its acrylamide-grafted and carboxymethylated copolymers.
31981693	7	0	from	immobile	1107:1114	arg1	gels					1123:1126	all gels	1119:1126	all gels	1119:1126	Additionally, 100 nm anionic NPs migrated slower than neutral NPs in VL and VM, while cationic NPs were immobile in all gels.
31981693	4	1	theme	oscillatory	651:661	arg1	rheology					663:670	oscillatory rheology	651:670	oscillatory rheology	651:670	Viscoelastic behavior was evaluated using oscillatory rheology, and migration of differently sized and charged polystyrene nanoparticles (NPs) through the different gels was determined via multiple particle tracking.
31981693	7	2	theme	anionic	1024:1030	arg1	NPs					1032:1034	100 nm anionic NPs	1017:1034	100 nm anionic NPs	1017:1034	Additionally, 100 nm anionic NPs migrated slower than neutral NPs in VL and VM, while cationic NPs were immobile in all gels.
31981693	1	3	theme	immense	164:170	arg1	potential					172:180	immense potential	164:180	immense potential for use	164:188	Artificial vitreous humor holds immense potential for use in in vitro intravitreal drug delivery assays.
31981693	6	4	theme	NP	989:990	arg1	migration					992:1000	NP migration	989:1000	NP migration	989:1000	Tracking evaluations revealed that increasing particle size and gel viscosity slowed NP migration.
31981693	0	5	theme	in	82:83	arg1	drug					91:94	in vitro drug	82:94	in vitro drug	82:94	Validation of hyaluronic acid-agar-based hydrogels as vitreous humor mimetics for in vitro drug and particle migration evaluations.
31981693	11	6	used	used	1550:1553	arg2	gels					1538:1541	low viscosity HA-agar gels	1516:1541	low viscosity HA-agar gels	1516:1541	Together, these evaluations demonstrate that low viscosity HA-agar gels can be used to approximate nanoparticle and drug migration through biological vitreous humor.
31981693	7	7	theme	cationic	1089:1096	arg1	NPs					1098:1100	cationic NPs	1089:1100	cationic NPs	1089:1100	Additionally, 100 nm anionic NPs migrated slower than neutral NPs in VL and VM, while cationic NPs were immobile in all gels.
31981693	4	8	theme	polystyrene	720:730	arg1	NPs					747:749	NPs	747:749	NPs	747:749	Viscoelastic behavior was evaluated using oscillatory rheology, and migration of differently sized and charged polystyrene nanoparticles (NPs) through the different gels was determined via multiple particle tracking.
31981693	4	8	theme	polystyrene	720:730	arg1	nanoparticles					732:744	differently sized and charged polystyrene nanoparticles	690:744	differently sized and charged polystyrene nanoparticles (NPs)	690:750	Viscoelastic behavior was evaluated using oscillatory rheology, and migration of differently sized and charged polystyrene nanoparticles (NPs) through the different gels was determined via multiple particle tracking.
31981693	7	9	from	gels	1123:1126	arg1	immobile					1107:1114	immobile	1107:1114	immobile	1107:1114	Additionally, 100 nm anionic NPs migrated slower than neutral NPs in VL and VM, while cationic NPs were immobile in all gels.
31981693	6	10	theme	gel	968:970	arg1	viscosity					972:980	gel viscosity	968:980	gel viscosity	968:980	Tracking evaluations revealed that increasing particle size and gel viscosity slowed NP migration.
31981693	4	11	theme	charged	712:718	arg1	NPs					747:749	NPs	747:749	NPs	747:749	Viscoelastic behavior was evaluated using oscillatory rheology, and migration of differently sized and charged polystyrene nanoparticles (NPs) through the different gels was determined via multiple particle tracking.
31981693	4	11	theme	charged	712:718	arg1	nanoparticles					732:744	differently sized and charged polystyrene nanoparticles	690:744	differently sized and charged polystyrene nanoparticles (NPs)	690:750	Viscoelastic behavior was evaluated using oscillatory rheology, and migration of differently sized and charged polystyrene nanoparticles (NPs) through the different gels was determined via multiple particle tracking.
31981693	2	12	theme	hyaluronic	329:338	arg1	HA					346:347	HA	346:347	HA	346:347	In this study, we investigated rheological properties and drug or nanoparticle migration in hyaluronic acid (HA) - agar based hydrogels and compared these characteristics with bovine vitreous humor.
31981693	2	12	theme	hyaluronic	329:338	arg1	acid					340:343	hyaluronic acid	329:343	hyaluronic acid (HA)	329:348	In this study, we investigated rheological properties and drug or nanoparticle migration in hyaluronic acid (HA) - agar based hydrogels and compared these characteristics with bovine vitreous humor.
31981693	0	13	theme	migration	109:117	arg1	evaluations					119:129	particle migration evaluations	100:129	particle migration evaluations	100:129	Validation of hyaluronic acid-agar-based hydrogels as vitreous humor mimetics for in vitro drug and particle migration evaluations.
31981693	11	14	theme	biological	1610:1619	arg1	humor					1630:1634	biological vitreous humor	1610:1634	biological vitreous humor	1610:1634	Together, these evaluations demonstrate that low viscosity HA-agar gels can be used to approximate nanoparticle and drug migration through biological vitreous humor.
31981693	4	15	theme	multiple	798:805	arg1	tracking					816:823	multiple particle tracking	798:823	multiple particle tracking	798:823	Viscoelastic behavior was evaluated using oscillatory rheology, and migration of differently sized and charged polystyrene nanoparticles (NPs) through the different gels was determined via multiple particle tracking.
31981693	2	16	theme	bovine	413:418	arg1	humor					429:433	bovine vitreous humor	413:433	bovine vitreous humor	413:433	In this study, we investigated rheological properties and drug or nanoparticle migration in hyaluronic acid (HA) - agar based hydrogels and compared these characteristics with bovine vitreous humor.
31981693	3	17	theme	Gel	436:438	arg1	high					560:563	high	560:563	high	560:563	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml) were classified as either high (VH), medium (VM) or low (VL) polymer load.
31981693	3	17	theme	Gel	436:438	arg1	compositions					440:451	Gel compositions	436:451	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml)	436:532	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml) were classified as either high (VH), medium (VM) or low (VL) polymer load.
31981693	0	18	theme	particle	100:107	arg1	evaluations					119:129	particle migration evaluations	100:129	particle migration evaluations	100:129	Validation of hyaluronic acid-agar-based hydrogels as vitreous humor mimetics for in vitro drug and particle migration evaluations.
31981693	11	19	theme	drug	1587:1590	arg1	migration					1592:1600	drug migration	1587:1600	drug migration	1587:1600	Together, these evaluations demonstrate that low viscosity HA-agar gels can be used to approximate nanoparticle and drug migration through biological vitreous humor.
31981693	10	20	theme	similar	1400:1406	arg1	clearance					1427:1435	the most similar sodium fluorescein clearance	1391:1435	the most similar sodium fluorescein clearance	1391:1435	Finally, VL and VM demonstrated to have the most similar sodium fluorescein clearance to that of bovine vitreous humor.
31981693	2	21	theme	rheological	268:278	arg1	properties					280:289	rheological properties	268:289	rheological properties	268:289	In this study, we investigated rheological properties and drug or nanoparticle migration in hyaluronic acid (HA) - agar based hydrogels and compared these characteristics with bovine vitreous humor.
31981693	7	22	from	NPs	1065:1067	arg1	VM					1079:1080	VM	1079:1080	VM	1079:1080	Additionally, 100 nm anionic NPs migrated slower than neutral NPs in VL and VM, while cationic NPs were immobile in all gels.
31981693	7	22	from	NPs	1065:1067	arg1	VL					1072:1073	VL	1072:1073	VL	1072:1073	Additionally, 100 nm anionic NPs migrated slower than neutral NPs in VL and VM, while cationic NPs were immobile in all gels.
31981693	5	23	theme	Comparable	826:835	arg1	behaviour					849:857	Comparable rheological behaviour	826:857	Comparable rheological behaviour	826:857	Comparable rheological behaviour was observed between VL and bovine vitreous.
31981693	9	24	theme	angular	1277:1283	arg1	movement					1285:1292	angular movement	1277:1292	angular movement	1277:1292	Flow and angular movement only influenced drug migration in VL and VM, but not VH.
31981693	8	25	theme	drug	1205:1208	arg1	mobility					1210:1217	drug mobility	1205:1217	drug mobility	1205:1217	Finally, distribution and clearance of sodium fluorescein was used to model drug mobility through the gels using a custom-built eye model.
31981693	11	26	theme	low	1516:1518	arg1	gels					1538:1541	low viscosity HA-agar gels	1516:1541	low viscosity HA-agar gels	1516:1541	Together, these evaluations demonstrate that low viscosity HA-agar gels can be used to approximate nanoparticle and drug migration through biological vitreous humor.
31981693	5	27	theme	rheological	837:847	arg1	behaviour					849:857	Comparable rheological behaviour	826:857	Comparable rheological behaviour	826:857	Comparable rheological behaviour was observed between VL and bovine vitreous.
31981693	4	28	theme	particle	807:814	arg1	tracking					816:823	multiple particle tracking	798:823	multiple particle tracking	798:823	Viscoelastic behavior was evaluated using oscillatory rheology, and migration of differently sized and charged polystyrene nanoparticles (NPs) through the different gels was determined via multiple particle tracking.
31981693	0	29	dep	in	82:83	arg1	vitro					85:89	vitro	85:89	vitro	85:89	Validation of hyaluronic acid-agar-based hydrogels as vitreous humor mimetics for in vitro drug and particle migration evaluations.
31981693	1	30	theme	in	193:194	arg1	assays					229:234	in vitro intravitreal drug delivery assays	193:234	in vitro intravitreal drug delivery assays	193:234	Artificial vitreous humor holds immense potential for use in in vitro intravitreal drug delivery assays.
31981693	0	31	theme	acid-agar-based	25:39	arg1	hydrogels					41:49	hyaluronic acid-agar-based hydrogels	14:49	hyaluronic acid-agar-based hydrogels as vitreous humor	14:67	Validation of hyaluronic acid-agar-based hydrogels as vitreous humor mimetics for in vitro drug and particle migration evaluations.
31981693	7	32	theme	neutral	1057:1063	arg1	NPs					1065:1067	neutral NPs	1057:1067	neutral NPs in VL and VM	1057:1080	Additionally, 100 nm anionic NPs migrated slower than neutral NPs in VL and VM, while cationic NPs were immobile in all gels.
31981693	2	33	theme	nanoparticle	303:314	arg1	migration					316:324	nanoparticle migration	303:324	nanoparticle migration	303:324	In this study, we investigated rheological properties and drug or nanoparticle migration in hyaluronic acid (HA) - agar based hydrogels and compared these characteristics with bovine vitreous humor.
31981693	2	34	theme	vitreous	420:427	arg1	humor					429:433	bovine vitreous humor	413:433	bovine vitreous humor	413:433	In this study, we investigated rheological properties and drug or nanoparticle migration in hyaluronic acid (HA) - agar based hydrogels and compared these characteristics with bovine vitreous humor.
31981693	0	35	theme	hyaluronic	14:23	arg1	hydrogels					41:49	hyaluronic acid-agar-based hydrogels	14:49	hyaluronic acid-agar-based hydrogels as vitreous humor	14:67	Validation of hyaluronic acid-agar-based hydrogels as vitreous humor mimetics for in vitro drug and particle migration evaluations.
31981693	6	36	theme	particle	950:957	arg1	size					959:962	particle size	950:962	particle size	950:962	Tracking evaluations revealed that increasing particle size and gel viscosity slowed NP migration.
31981693	10	37	theme	fluorescein	1415:1425	arg1	clearance					1427:1435	the most similar sodium fluorescein clearance	1391:1435	the most similar sodium fluorescein clearance	1391:1435	Finally, VL and VM demonstrated to have the most similar sodium fluorescein clearance to that of bovine vitreous humor.
31981693	4	38	theme	sized	702:706	arg1	NPs					747:749	NPs	747:749	NPs	747:749	Viscoelastic behavior was evaluated using oscillatory rheology, and migration of differently sized and charged polystyrene nanoparticles (NPs) through the different gels was determined via multiple particle tracking.
31981693	4	38	theme	sized	702:706	arg1	nanoparticles					732:744	differently sized and charged polystyrene nanoparticles	690:744	differently sized and charged polystyrene nanoparticles (NPs)	690:750	Viscoelastic behavior was evaluated using oscillatory rheology, and migration of differently sized and charged polystyrene nanoparticles (NPs) through the different gels was determined via multiple particle tracking.
31981693	1	39	theme	intravitreal	202:213	arg1	assays					229:234	in vitro intravitreal drug delivery assays	193:234	in vitro intravitreal drug delivery assays	193:234	Artificial vitreous humor holds immense potential for use in in vitro intravitreal drug delivery assays.
31981693	8	40	theme	fluorescein	1175:1185	arg1	clearance					1155:1163	clearance	1155:1163	clearance	1155:1163	Finally, distribution and clearance of sodium fluorescein was used to model drug mobility through the gels using a custom-built eye model.
31981693	8	40	theme	fluorescein	1175:1185	arg1	distribution					1138:1149	distribution	1138:1149	distribution	1138:1149	Finally, distribution and clearance of sodium fluorescein was used to model drug mobility through the gels using a custom-built eye model.
31981693	9	41	theme	drug	1310:1313	arg1	migration					1315:1323	drug migration	1310:1323	drug migration	1310:1323	Flow and angular movement only influenced drug migration in VL and VM, but not VH.
31981693	10	42	theme	sodium	1408:1413	arg1	clearance					1427:1435	the most similar sodium fluorescein clearance	1391:1435	the most similar sodium fluorescein clearance	1391:1435	Finally, VL and VM demonstrated to have the most similar sodium fluorescein clearance to that of bovine vitreous humor.
31981693	3	43	theme	polymer	595:601	arg1	high					560:563	high	560:563	high	560:563	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml) were classified as either high (VH), medium (VM) or low (VL) polymer load.
31981693	3	43	theme	polymer	595:601	arg1	load					603:606	low (VL) polymer load	586:606	low (VL) polymer load	586:606	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml) were classified as either high (VH), medium (VM) or low (VL) polymer load.
31981693	4	44	theme	Viscoelastic	609:620	arg1	behavior					622:629	Viscoelastic behavior	609:629	Viscoelastic behavior	609:629	Viscoelastic behavior was evaluated using oscillatory rheology, and migration of differently sized and charged polystyrene nanoparticles (NPs) through the different gels was determined via multiple particle tracking.
31981693	1	45	theme	drug	215:218	arg1	assays					229:234	in vitro intravitreal drug delivery assays	193:234	in vitro intravitreal drug delivery assays	193:234	Artificial vitreous humor holds immense potential for use in in vitro intravitreal drug delivery assays.
31981693	0	46	theme	hydrogels	41:49	arg1	Validation					0:9	Validation	0:9	Validation of hyaluronic acid-agar-based hydrogels as vitreous humor	0:67	Validation of hyaluronic acid-agar-based hydrogels as vitreous humor mimetics for in vitro drug and particle migration evaluations.
31981693	8	47	theme	sodium	1168:1173	arg1	fluorescein					1175:1185	sodium fluorescein	1168:1185	sodium fluorescein	1168:1185	Finally, distribution and clearance of sodium fluorescein was used to model drug mobility through the gels using a custom-built eye model.
31981693	3	48	contain	containing	478:487	arg2	0.95-4.0 mg/ml					518:531	0.95-4.0 mg/ml	518:531	0.95-4.0 mg/ml	518:531	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml) were classified as either high (VH), medium (VM) or low (VL) polymer load.
31981693	3	48	contain	containing	478:487	arg2	HA					489:490	HA	489:490	HA (0.7-5.0 mg/ml)	489:506	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml) were classified as either high (VH), medium (VM) or low (VL) polymer load.
31981693	3	48	contain	containing	478:487	arg2	agar					512:515	agar	512:515	agar (0.95-4.0 mg/ml)	512:532	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml) were classified as either high (VH), medium (VM) or low (VL) polymer load.
31981693	3	48	contain	containing	478:487	arg1	literature					467:476	literature	467:476	literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml)	467:532	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml) were classified as either high (VH), medium (VM) or low (VL) polymer load.
31981693	3	48	contain	containing	478:487	arg2	0.7-5.0 mg/ml					493:505	0.7-5.0 mg/ml	493:505	0.7-5.0 mg/ml	493:505	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml) were classified as either high (VH), medium (VM) or low (VL) polymer load.
31981693	1	49	dep	in	193:194	arg1	vitro					196:200	vitro	196:200	vitro	196:200	Artificial vitreous humor holds immense potential for use in in vitro intravitreal drug delivery assays.
31981693	11	50	theme	viscosity	1520:1528	arg1	gels					1538:1541	low viscosity HA-agar gels	1516:1541	low viscosity HA-agar gels	1516:1541	Together, these evaluations demonstrate that low viscosity HA-agar gels can be used to approximate nanoparticle and drug migration through biological vitreous humor.
31981693	1	51	theme	delivery	220:227	arg1	assays					229:234	in vitro intravitreal drug delivery assays	193:234	in vitro intravitreal drug delivery assays	193:234	Artificial vitreous humor holds immense potential for use in in vitro intravitreal drug delivery assays.
31981693	10	52	theme	bovine	1448:1453	arg1	humor					1464:1468	bovine vitreous humor	1448:1468	bovine vitreous humor	1448:1468	Finally, VL and VM demonstrated to have the most similar sodium fluorescein clearance to that of bovine vitreous humor.
31981693	3	53	theme	VL	591:592	arg1	high					560:563	high	560:563	high	560:563	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml) were classified as either high (VH), medium (VM) or low (VL) polymer load.
31981693	3	53	theme	VL	591:592	arg1	load					603:606	low (VL) polymer load	586:606	low (VL) polymer load	586:606	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml) were classified as either high (VH), medium (VM) or low (VL) polymer load.
31981693	5	54	dep	VL	880:881	arg1	vitreous					894:901	vitreous	894:901	vitreous	894:901	Comparable rheological behaviour was observed between VL and bovine vitreous.
31981693	8	55	theme	custom-built	1244:1255	arg1	model					1261:1265	a custom-built eye model	1242:1265	a custom-built eye model	1242:1265	Finally, distribution and clearance of sodium fluorescein was used to model drug mobility through the gels using a custom-built eye model.
31981693	0	56	theme	vitreous	54:61	arg1	humor					63:67	vitreous humor	54:67	vitreous humor	54:67	Validation of hyaluronic acid-agar-based hydrogels as vitreous humor mimetics for in vitro drug and particle migration evaluations.
31981693	8	57	used	used	1191:1194	arg2	distribution					1138:1149	distribution	1138:1149	distribution	1138:1149	Finally, distribution and clearance of sodium fluorescein was used to model drug mobility through the gels using a custom-built eye model.
31981693	8	57	used	used	1191:1194	arg2	clearance					1155:1163	clearance	1155:1163	clearance	1155:1163	Finally, distribution and clearance of sodium fluorescein was used to model drug mobility through the gels using a custom-built eye model.
31981693	11	58	theme	vitreous	1621:1628	arg1	humor					1630:1634	biological vitreous humor	1610:1634	biological vitreous humor	1610:1634	Together, these evaluations demonstrate that low viscosity HA-agar gels can be used to approximate nanoparticle and drug migration through biological vitreous humor.
31981693	6	59	theme	Tracking	904:911	arg1	evaluations					913:923	Tracking evaluations	904:923	Tracking evaluations	904:923	Tracking evaluations revealed that increasing particle size and gel viscosity slowed NP migration.
31981693	7	60	theme	100 nm	1017:1022	arg1	NPs					1032:1034	100 nm anionic NPs	1017:1034	100 nm anionic NPs	1017:1034	Additionally, 100 nm anionic NPs migrated slower than neutral NPs in VL and VM, while cationic NPs were immobile in all gels.
31981693	4	61	theme	different	764:772	arg1	gels					774:777	the different gels	760:777	the different gels	760:777	Viscoelastic behavior was evaluated using oscillatory rheology, and migration of differently sized and charged polystyrene nanoparticles (NPs) through the different gels was determined via multiple particle tracking.
31981693	1	62	theme	Artificial	132:141	arg1	humor					152:156	Artificial vitreous humor	132:156	Artificial vitreous humor	132:156	Artificial vitreous humor holds immense potential for use in in vitro intravitreal drug delivery assays.
31981693	4	63	theme	nanoparticles	732:744	arg1	migration					677:685	migration	677:685	migration of differently sized and charged polystyrene nanoparticles (NPs) through the different gels	677:777	Viscoelastic behavior was evaluated using oscillatory rheology, and migration of differently sized and charged polystyrene nanoparticles (NPs) through the different gels was determined via multiple particle tracking.
31981693	3	64	theme	low	586:588	arg1	high					560:563	high	560:563	high	560:563	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml) were classified as either high (VH), medium (VM) or low (VL) polymer load.
31981693	3	64	theme	low	586:588	arg1	load					603:606	low (VL) polymer load	586:606	low (VL) polymer load	586:606	Gel compositions identified in literature containing HA (0.7-5.0 mg/ml) and agar (0.95-4.0 mg/ml) were classified as either high (VH), medium (VM) or low (VL) polymer load.
31981693	10	65	contain	have	1386:1389	arg1	VM					1367:1368	VM	1367:1368	VM	1367:1368	Finally, VL and VM demonstrated to have the most similar sodium fluorescein clearance to that of bovine vitreous humor.
31981693	10	65	contain	have	1386:1389	arg1	VL					1360:1361	VL	1360:1361	VL	1360:1361	Finally, VL and VM demonstrated to have the most similar sodium fluorescein clearance to that of bovine vitreous humor.
31981693	10	65	contain	have	1386:1389	arg2	clearance					1427:1435	the most similar sodium fluorescein clearance	1391:1435	the most similar sodium fluorescein clearance	1391:1435	Finally, VL and VM demonstrated to have the most similar sodium fluorescein clearance to that of bovine vitreous humor.
31981693	1	66	theme	vitreous	143:150	arg1	humor					152:156	Artificial vitreous humor	132:156	Artificial vitreous humor	132:156	Artificial vitreous humor holds immense potential for use in in vitro intravitreal drug delivery assays.
31981693	2	67	theme	based	357:361	arg1	hydrogels					363:371	agar based hydrogels	352:371	agar based hydrogels	352:371	In this study, we investigated rheological properties and drug or nanoparticle migration in hyaluronic acid (HA) - agar based hydrogels and compared these characteristics with bovine vitreous humor.
31981693	8	68	theme	eye	1257:1259	arg1	model					1261:1265	a custom-built eye model	1242:1265	a custom-built eye model	1242:1265	Finally, distribution and clearance of sodium fluorescein was used to model drug mobility through the gels using a custom-built eye model.
31981693	10	69	theme	vitreous	1455:1462	arg1	humor					1464:1468	bovine vitreous humor	1448:1468	bovine vitreous humor	1448:1468	Finally, VL and VM demonstrated to have the most similar sodium fluorescein clearance to that of bovine vitreous humor.
31981693	11	70	theme	HA-agar	1530:1536	arg1	gels					1538:1541	low viscosity HA-agar gels	1516:1541	low viscosity HA-agar gels	1516:1541	Together, these evaluations demonstrate that low viscosity HA-agar gels can be used to approximate nanoparticle and drug migration through biological vitreous humor.
31981693	2	71	theme	agar	352:355	arg1	hydrogels					363:371	agar based hydrogels	352:371	agar based hydrogels	352:371	In this study, we investigated rheological properties and drug or nanoparticle migration in hyaluronic acid (HA) - agar based hydrogels and compared these characteristics with bovine vitreous humor.
33940669	12	0	theme	surface	1706:1712	arg1	analysis					1723:1730	dentin surface chemical analysis	1699:1730	dentin surface chemical analysis	1699:1730	From the point of view of dentin surface chemical analysis, more studies with P-Chi should be conducted to achieve greater interactions with surfaces and to improve the adhesive interface.
33940669	11	1	theme	phosphorylated	1543:1556	arg1	P-Chi					1568:1572	P-Chi	1568:1572	P-Chi	1568:1572	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	11	1	theme	phosphorylated	1543:1556	arg1	chitosan					1558:1565	2.5% phosphorylated chitosan	1538:1565	2.5% phosphorylated chitosan (P-Chi)	1538:1573	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	2	2	theme	specimens	345:353	arg1	21					333:334	21	333:334	21	333:334	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	2	2	theme	specimens	345:353	arg1	specimens					345:353	these specimens	339:353	these specimens	339:353	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	6	3	theme	related	1033:1039	arg1	bands					1041:1045	related bands	1033:1045	related bands	1033:1045	RESULTS Dentin erosion reduced the intensity of the phosphate (1,100 cm⁻¹) and carbonate (872 cm⁻¹) related bands, which evidenced demineralization.
33940669	11	4	theme	SIGNIFICANCE	1461:1472	arg1	indicator					1590:1598	a promising indicator	1578:1598	a promising indicator for further studies	1578:1618	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	11	4	theme	SIGNIFICANCE	1461:1472	arg1	demineralization					1488:1503	CLINICAL SIGNIFICANCE Eroded dentin demineralization	1452:1503	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi)	1452:1573	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	1	5	theme	eroded	190:195	arg1	dentin					197:202	eroded dentin	190:202	eroded dentin	190:202	PURPOSE To evaluate the chemical composition and morphological properties of eroded dentin after biomodification with phosphorylated chitosan (P-Chi) and carbodiimide (EDC).
33940669	2	6	theme	dentin	305:310	arg1	specimens					312:320	42 bovine dentin specimens	295:320	METHODS 42 bovine dentin specimens	287:320	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	0	7	theme	chitosan	25:32	arg1	Effect					0:5	Effect	0:5	Effect of phosphorylated chitosan and carbodiimide biomodification on the chemical composition of eroded dentin.	0:111	Effect of phosphorylated chitosan and carbodiimide biomodification on the chemical composition of eroded dentin.
33940669	1	8	dep	composition	146:156	arg1	the					133:135	the	133:135	the	133:135	PURPOSE To evaluate the chemical composition and morphological properties of eroded dentin after biomodification with phosphorylated chitosan (P-Chi) and carbodiimide (EDC).
33940669	3	9	theme	dentin	502:507	arg1	substrate					509:517	dentin substrate	502:517	dentin substrate (sound or eroded)	502:535	The specimens were randomly divided into six groups according to dentin substrate (sound or eroded) and biomodification [with 2.5% P-Chi, with 0.5 mol/L EDC, or no biomodification (control)].
33940669	3	10	dep	substrate	509:517	arg1	sound					520:524	sound	520:524	sound	520:524	The specimens were randomly divided into six groups according to dentin substrate (sound or eroded) and biomodification [with 2.5% P-Chi, with 0.5 mol/L EDC, or no biomodification (control)].
33940669	3	10	dep	substrate	509:517	arg1	eroded					529:534	eroded	529:534	eroded	529:534	The specimens were randomly divided into six groups according to dentin substrate (sound or eroded) and biomodification [with 2.5% P-Chi, with 0.5 mol/L EDC, or no biomodification (control)].
33940669	2	11	dep	METHODS	287:293	arg1	specimens					312:320	42 bovine dentin specimens	295:320	METHODS 42 bovine dentin specimens	287:320	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	11	12	theme	intrinsic	1646:1654	arg1	characteristics					1656:1670	the dentin intrinsic characteristics	1635:1670	the dentin intrinsic characteristics	1635:1670	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	3	13	theme	%	566:566	arg1	P-Chi					568:572	2.5% P-Chi	563:572	2.5% P-Chi	563:572	The specimens were randomly divided into six groups according to dentin substrate (sound or eroded) and biomodification [with 2.5% P-Chi, with 0.5 mol/L EDC, or no biomodification (control)].
33940669	4	14	theme	surface	859:865	arg1	morphology					867:876	surface morphology	859:876	surface morphology	859:876	The specimens were analyzed by Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate) and atomic force microscopy (AFM, n= 2) to verify the phosphate, carbonate, and organic matrix absorption peaks and to investigate surface morphology, respectively.
33940669	4	15	dep	spectroscopy	687:698	arg1	n=					707:708	n= 5	707:710	n= 5	707:710	The specimens were analyzed by Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate) and atomic force microscopy (AFM, n= 2) to verify the phosphate, carbonate, and organic matrix absorption peaks and to investigate surface morphology, respectively.
33940669	4	15	dep	spectroscopy	687:698	arg1	FTIR					701:704	FTIR	701:704	FTIR	701:704	The specimens were analyzed by Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate) and atomic force microscopy (AFM, n= 2) to verify the phosphate, carbonate, and organic matrix absorption peaks and to investigate surface morphology, respectively.
33940669	4	16	theme	matrix	816:821	arg1	peaks					834:838	organic matrix absorption peaks	808:838	organic matrix absorption peaks	808:838	The specimens were analyzed by Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate) and atomic force microscopy (AFM, n= 2) to verify the phosphate, carbonate, and organic matrix absorption peaks and to investigate surface morphology, respectively.
33940669	0	17	from	Effect	0:5	arg1	composition					83:93	the chemical composition	70:93	the chemical composition of eroded dentin	70:110	Effect of phosphorylated chitosan and carbodiimide biomodification on the chemical composition of eroded dentin.
33940669	8	18	with	compatible	1236:1245	arg1	demineralization					1260:1275	surface demineralization	1252:1275	surface demineralization	1252:1275	Modification with P-Chi removed intertubular dentin, which was compatible with surface demineralization; however, this modification obliterated dentin tubules.
33940669	0	19	theme	eroded	98:103	arg1	dentin					105:110	eroded dentin	98:110	eroded dentin	98:110	Effect of phosphorylated chitosan and carbodiimide biomodification on the chemical composition of eroded dentin.
33940669	1	20	theme	chemical	137:144	arg1	composition					146:156	chemical composition	137:156	chemical composition	137:156	PURPOSE To evaluate the chemical composition and morphological properties of eroded dentin after biomodification with phosphorylated chitosan (P-Chi) and carbodiimide (EDC).
33940669	2	21	theme	0.3	396:398	arg1	%					399:399	%	399:399	%	399:399	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	0	22	theme	chemical	74:81	arg1	composition					83:93	the chemical composition	70:93	the chemical composition of eroded dentin	70:110	Effect of phosphorylated chitosan and carbodiimide biomodification on the chemical composition of eroded dentin.
33940669	4	23	theme	infrared	678:685	arg1	spectroscopy					687:698	Fourier-transform infrared spectroscopy	660:698	Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate)	660:726	The specimens were analyzed by Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate) and atomic force microscopy (AFM, n= 2) to verify the phosphate, carbonate, and organic matrix absorption peaks and to investigate surface morphology, respectively.
33940669	1	24	with	biomodification	210:224	arg1	EDC					281:283	EDC	281:283	EDC	281:283	PURPOSE To evaluate the chemical composition and morphological properties of eroded dentin after biomodification with phosphorylated chitosan (P-Chi) and carbodiimide (EDC).
33940669	1	24	with	biomodification	210:224	arg1	P-Chi					256:260	P-Chi	256:260	P-Chi	256:260	PURPOSE To evaluate the chemical composition and morphological properties of eroded dentin after biomodification with phosphorylated chitosan (P-Chi) and carbodiimide (EDC).
33940669	1	24	with	biomodification	210:224	arg1	carbodiimide					267:278	carbodiimide	267:278	carbodiimide (EDC)	267:284	PURPOSE To evaluate the chemical composition and morphological properties of eroded dentin after biomodification with phosphorylated chitosan (P-Chi) and carbodiimide (EDC).
33940669	1	24	with	biomodification	210:224	arg1	chitosan					246:253	phosphorylated chitosan	231:253	phosphorylated chitosan (P-Chi)	231:261	PURPOSE To evaluate the chemical composition and morphological properties of eroded dentin after biomodification with phosphorylated chitosan (P-Chi) and carbodiimide (EDC).
33940669	6	25	theme	RESULTS	933:939	arg1	erosion					948:954	RESULTS Dentin erosion	933:954	RESULTS Dentin erosion	933:954	RESULTS Dentin erosion reduced the intensity of the phosphate (1,100 cm⁻¹) and carbonate (872 cm⁻¹) related bands, which evidenced demineralization.
33940669	2	26	theme	=	417:417	arg1	pH					414:415	pH = 3.2	414:421	pH = 3.2	414:421	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	2	26	theme	=	417:417	arg1	acid					408:411	0.3% citric acid	396:411	0.3% citric acid (pH = 3.2)	396:422	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	8	27	theme	surface	1252:1258	arg1	demineralization					1260:1275	surface demineralization	1252:1275	surface demineralization	1252:1275	Modification with P-Chi removed intertubular dentin, which was compatible with surface demineralization; however, this modification obliterated dentin tubules.
33940669	0	28	theme	phosphorylated	10:23	arg1	chitosan					25:32	chitosan	25:32	chitosan	25:32	Effect of phosphorylated chitosan and carbodiimide biomodification on the chemical composition of eroded dentin.
33940669	2	29	theme	citric	401:406	arg1	pH					414:415	pH = 3.2	414:421	pH = 3.2	414:421	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	2	29	theme	citric	401:406	arg1	acid					408:411	0.3% citric acid	396:411	0.3% citric acid (pH = 3.2)	396:422	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	7	30	theme	open	1159:1162	arg1	tubules					1164:1170	slightly more open tubules	1145:1170	slightly more open tubules	1145:1170	Eroded dentin consisted of a more irregular surface containing slightly more open tubules.
33940669	4	31	theme	atomic	732:737	arg1	microscopy					745:754	atomic force microscopy	732:754	atomic force microscopy (AFM, n= 2)	732:766	The specimens were analyzed by Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate) and atomic force microscopy (AFM, n= 2) to verify the phosphate, carbonate, and organic matrix absorption peaks and to investigate surface morphology, respectively.
33940669	10	32	theme	irregular	1401:1409	arg1	surface					1411:1417	a more irregular surface	1394:1417	a more irregular surface	1394:1417	Biomodified dentin had a more irregular surface, irrespective of substrate type.
33940669	11	33	theme	dentin	1639:1644	arg1	characteristics					1656:1670	the dentin intrinsic characteristics	1635:1670	the dentin intrinsic characteristics	1635:1670	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	12	34	theme	dentin	1699:1704	arg1	analysis					1723:1730	dentin surface chemical analysis	1699:1730	dentin surface chemical analysis	1699:1730	From the point of view of dentin surface chemical analysis, more studies with P-Chi should be conducted to achieve greater interactions with surfaces and to improve the adhesive interface.
33940669	6	35	theme	phosphate	985:993	arg1	intensity					968:976	the intensity	964:976	the intensity	964:976	RESULTS Dentin erosion reduced the intensity of the phosphate (1,100 cm⁻¹) and carbonate (872 cm⁻¹) related bands, which evidenced demineralization.
33940669	8	36	with	Modification	1173:1184	arg1	P-Chi					1191:1195	P-Chi	1191:1195	P-Chi	1191:1195	Modification with P-Chi removed intertubular dentin, which was compatible with surface demineralization; however, this modification obliterated dentin tubules.
33940669	8	37	theme	dentin	1317:1322	arg1	tubules					1324:1330	dentin tubules	1317:1330	dentin tubules	1317:1330	Modification with P-Chi removed intertubular dentin, which was compatible with surface demineralization; however, this modification obliterated dentin tubules.
33940669	11	38	theme	%	1541:1541	arg1	P-Chi					1568:1572	P-Chi	1568:1572	P-Chi	1568:1572	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	11	38	theme	%	1541:1541	arg1	chitosan					1558:1565	2.5% phosphorylated chitosan	1538:1565	2.5% phosphorylated chitosan (P-Chi)	1538:1573	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	3	39	dep	mol/L	584:588	arg1	0.5					580:582	0.5	580:582	0.5	580:582	The specimens were randomly divided into six groups according to dentin substrate (sound or eroded) and biomodification [with 2.5% P-Chi, with 0.5 mol/L EDC, or no biomodification (control)].
33940669	2	40	with	challenge	381:389	arg1	pH					414:415	pH = 3.2	414:421	pH = 3.2	414:421	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	2	40	with	challenge	381:389	arg1	acid					408:411	0.3% citric acid	396:411	0.3% citric acid (pH = 3.2)	396:422	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	12	41	theme	chemical	1714:1721	arg1	analysis					1723:1730	dentin surface chemical analysis	1699:1730	dentin surface chemical analysis	1699:1730	From the point of view of dentin surface chemical analysis, more studies with P-Chi should be conducted to achieve greater interactions with surfaces and to improve the adhesive interface.
33940669	2	42	theme	bovine	298:303	arg1	specimens					312:320	42 bovine dentin specimens	295:320	METHODS 42 bovine dentin specimens	287:320	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	12	43	theme	view	1691:1694	arg1	point					1682:1686	the point	1678:1686	the point of view of dentin surface chemical analysis	1678:1730	From the point of view of dentin surface chemical analysis, more studies with P-Chi should be conducted to achieve greater interactions with surfaces and to improve the adhesive interface.
33940669	11	44	theme	promising	1580:1588	arg1	indicator					1590:1598	a promising indicator	1578:1598	a promising indicator for further studies	1578:1618	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	11	44	theme	promising	1580:1588	arg1	demineralization					1488:1503	CLINICAL SIGNIFICANCE Eroded dentin demineralization	1452:1503	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi)	1452:1573	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	12	45	with	studies	1738:1744	arg1	P-Chi					1751:1755	P-Chi	1751:1755	P-Chi	1751:1755	From the point of view of dentin surface chemical analysis, more studies with P-Chi should be conducted to achieve greater interactions with surfaces and to improve the adhesive interface.
33940669	4	46	theme	force	739:743	arg1	microscopy					745:754	atomic force microscopy	732:754	atomic force microscopy (AFM, n= 2)	732:766	The specimens were analyzed by Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate) and atomic force microscopy (AFM, n= 2) to verify the phosphate, carbonate, and organic matrix absorption peaks and to investigate surface morphology, respectively.
33940669	11	47	theme	Eroded	1474:1479	arg1	indicator					1590:1598	a promising indicator	1578:1598	a promising indicator for further studies	1578:1618	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	11	47	theme	Eroded	1474:1479	arg1	demineralization					1488:1503	CLINICAL SIGNIFICANCE Eroded dentin demineralization	1452:1503	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi)	1452:1573	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	1	48	theme	dentin	197:202	arg1	composition					146:156	chemical composition	137:156	chemical composition	137:156	PURPOSE To evaluate the chemical composition and morphological properties of eroded dentin after biomodification with phosphorylated chitosan (P-Chi) and carbodiimide (EDC).
33940669	1	48	theme	dentin	197:202	arg1	properties					176:185	morphological properties	162:185	morphological properties	162:185	PURPOSE To evaluate the chemical composition and morphological properties of eroded dentin after biomodification with phosphorylated chitosan (P-Chi) and carbodiimide (EDC).
33940669	6	49	theme	carbonate	1012:1020	arg1	intensity					968:976	the intensity	964:976	the intensity	964:976	RESULTS Dentin erosion reduced the intensity of the phosphate (1,100 cm⁻¹) and carbonate (872 cm⁻¹) related bands, which evidenced demineralization.
33940669	11	50	theme	CLINICAL	1452:1459	arg1	indicator					1590:1598	a promising indicator	1578:1598	a promising indicator for further studies	1578:1618	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	11	50	theme	CLINICAL	1452:1459	arg1	demineralization					1488:1503	CLINICAL SIGNIFICANCE Eroded dentin demineralization	1452:1503	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi)	1452:1573	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	3	51	theme	biomodification	541:555	arg1	[with					557:561	biomodification [with	541:561	biomodification [with	541:561	The specimens were randomly divided into six groups according to dentin substrate (sound or eroded) and biomodification [with 2.5% P-Chi, with 0.5 mol/L EDC, or no biomodification (control)].
33940669	1	52	theme	phosphorylated	231:244	arg1	P-Chi					256:260	P-Chi	256:260	P-Chi	256:260	PURPOSE To evaluate the chemical composition and morphological properties of eroded dentin after biomodification with phosphorylated chitosan (P-Chi) and carbodiimide (EDC).
33940669	1	52	theme	phosphorylated	231:244	arg1	chitosan					246:253	phosphorylated chitosan	231:253	phosphorylated chitosan (P-Chi)	231:261	PURPOSE To evaluate the chemical composition and morphological properties of eroded dentin after biomodification with phosphorylated chitosan (P-Chi) and carbodiimide (EDC).
33940669	10	53	contain	had	1390:1392	arg2	surface					1411:1417	a more irregular surface	1394:1417	a more irregular surface	1394:1417	Biomodified dentin had a more irregular surface, irrespective of substrate type.
33940669	10	53	contain	had	1390:1392	arg1	dentin					1383:1388	Biomodified dentin	1371:1388	Biomodified dentin	1371:1388	Biomodified dentin had a more irregular surface, irrespective of substrate type.
33940669	7	54	theme	Eroded	1082:1087	arg1	dentin					1089:1094	Eroded dentin	1082:1094	Eroded dentin	1082:1094	Eroded dentin consisted of a more irregular surface containing slightly more open tubules.
33940669	3	55	theme	2.5	563:565	arg1	%					566:566	%	566:566	%	566:566	The specimens were randomly divided into six groups according to dentin substrate (sound or eroded) and biomodification [with 2.5% P-Chi, with 0.5 mol/L EDC, or no biomodification (control)].
33940669	1	56	theme	morphological	162:174	arg1	properties					176:185	morphological properties	162:185	morphological properties	162:185	PURPOSE To evaluate the chemical composition and morphological properties of eroded dentin after biomodification with phosphorylated chitosan (P-Chi) and carbodiimide (EDC).
33940669	0	57	theme	dentin	105:110	arg1	composition					83:93	the chemical composition	70:93	the chemical composition of eroded dentin	70:110	Effect of phosphorylated chitosan and carbodiimide biomodification on the chemical composition of eroded dentin.
33940669	12	58	theme	adhesive	1842:1849	arg1	interface					1851:1859	the adhesive interface	1838:1859	the adhesive interface	1838:1859	From the point of view of dentin surface chemical analysis, more studies with P-Chi should be conducted to achieve greater interactions with surfaces and to improve the adhesive interface.
33940669	4	59	from	FTIR	701:704	arg1	triplicate					716:725	triplicate	716:725	triplicate	716:725	The specimens were analyzed by Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate) and atomic force microscopy (AFM, n= 2) to verify the phosphate, carbonate, and organic matrix absorption peaks and to investigate surface morphology, respectively.
33940669	4	60	theme	organic	808:814	arg1	peaks					834:838	organic matrix absorption peaks	808:838	organic matrix absorption peaks	808:838	The specimens were analyzed by Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate) and atomic force microscopy (AFM, n= 2) to verify the phosphate, carbonate, and organic matrix absorption peaks and to investigate surface morphology, respectively.
33940669	8	61	theme	intertubular	1205:1216	arg1	dentin					1218:1223	intertubular dentin	1205:1223	intertubular dentin	1205:1223	Modification with P-Chi removed intertubular dentin, which was compatible with surface demineralization; however, this modification obliterated dentin tubules.
33940669	4	62	theme	absorption	823:832	arg1	peaks					834:838	organic matrix absorption peaks	808:838	organic matrix absorption peaks	808:838	The specimens were analyzed by Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate) and atomic force microscopy (AFM, n= 2) to verify the phosphate, carbonate, and organic matrix absorption peaks and to investigate surface morphology, respectively.
33940669	7	63	contain	containing	1134:1143	arg1	surface					1126:1132	a more irregular surface	1109:1132	a more irregular surface containing slightly more open tubules	1109:1170	Eroded dentin consisted of a more irregular surface containing slightly more open tubules.
33940669	7	63	contain	containing	1134:1143	arg2	tubules					1164:1170	slightly more open tubules	1145:1170	slightly more open tubules	1145:1170	Eroded dentin consisted of a more irregular surface containing slightly more open tubules.
33940669	6	64	theme	Dentin	941:946	arg1	erosion					948:954	RESULTS Dentin erosion	933:954	RESULTS Dentin erosion	933:954	RESULTS Dentin erosion reduced the intensity of the phosphate (1,100 cm⁻¹) and carbonate (872 cm⁻¹) related bands, which evidenced demineralization.
33940669	2	65	theme	erosive	373:379	arg1	challenge					381:389	erosive challenge	373:389	erosive challenge with 0.3% citric acid (pH = 3.2)	373:422	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	4	66	dep	microscopy	745:754	arg1	n=					762:763	n= 2	762:765	n= 2	762:765	The specimens were analyzed by Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate) and atomic force microscopy (AFM, n= 2) to verify the phosphate, carbonate, and organic matrix absorption peaks and to investigate surface morphology, respectively.
33940669	4	66	dep	microscopy	745:754	arg1	AFM					757:759	AFM	757:759	AFM	757:759	The specimens were analyzed by Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate) and atomic force microscopy (AFM, n= 2) to verify the phosphate, carbonate, and organic matrix absorption peaks and to investigate surface morphology, respectively.
33940669	11	67	theme	further	1604:1610	arg1	studies					1612:1618	further studies	1604:1618	further studies	1604:1618	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	4	68	theme	Fourier-transform	660:676	arg1	spectroscopy					687:698	Fourier-transform infrared spectroscopy	660:698	Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate)	660:726	The specimens were analyzed by Fourier-transform infrared spectroscopy (FTIR, n= 5, in triplicate) and atomic force microscopy (AFM, n= 2) to verify the phosphate, carbonate, and organic matrix absorption peaks and to investigate surface morphology, respectively.
33940669	0	69	theme	carbodiimide	38:49	arg1	Effect					0:5	Effect	0:5	Effect of phosphorylated chitosan and carbodiimide biomodification on the chemical composition of eroded dentin.	0:111	Effect of phosphorylated chitosan and carbodiimide biomodification on the chemical composition of eroded dentin.
33940669	12	70	theme	greater	1788:1794	arg1	interactions					1796:1807	greater interactions	1788:1807	greater interactions with surfaces	1788:1821	From the point of view of dentin surface chemical analysis, more studies with P-Chi should be conducted to achieve greater interactions with surfaces and to improve the adhesive interface.
33940669	7	71	theme	more	1154:1157	arg1	tubules					1164:1170	slightly more open tubules	1145:1170	slightly more open tubules	1145:1170	Eroded dentin consisted of a more irregular surface containing slightly more open tubules.
33940669	10	72	theme	Biomodified	1371:1381	arg1	dentin					1383:1388	Biomodified dentin	1371:1388	Biomodified dentin	1371:1388	Biomodified dentin had a more irregular surface, irrespective of substrate type.
33940669	2	73	theme	%	399:399	arg1	pH					414:415	pH = 3.2	414:421	pH = 3.2	414:421	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	2	73	theme	%	399:399	arg1	acid					408:411	0.3% citric acid	396:411	0.3% citric acid (pH = 3.2)	396:422	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	12	74	theme	analysis	1723:1730	arg1	view					1691:1694	view	1691:1694	view of dentin surface chemical analysis	1691:1730	From the point of view of dentin surface chemical analysis, more studies with P-Chi should be conducted to achieve greater interactions with surfaces and to improve the adhesive interface.
33940669	11	75	theme	dentin	1481:1486	arg1	indicator					1590:1598	a promising indicator	1578:1598	a promising indicator for further studies	1578:1618	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	11	75	theme	dentin	1481:1486	arg1	demineralization					1488:1503	CLINICAL SIGNIFICANCE Eroded dentin demineralization	1452:1503	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi)	1452:1573	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	12	76	with	interactions	1796:1807	arg1	surfaces					1814:1821	surfaces	1814:1821	surfaces	1814:1821	From the point of view of dentin surface chemical analysis, more studies with P-Chi should be conducted to achieve greater interactions with surfaces and to improve the adhesive interface.
33940669	0	77	dep	chitosan	25:32	arg1	biomodification					51:65	biomodification	51:65	biomodification	51:65	Effect of phosphorylated chitosan and carbodiimide biomodification on the chemical composition of eroded dentin.
33940669	12	78	theme	more	1733:1736	arg1	studies					1738:1744	more studies	1733:1744	more studies with P-Chi	1733:1755	From the point of view of dentin surface chemical analysis, more studies with P-Chi should be conducted to achieve greater interactions with surfaces and to improve the adhesive interface.
33940669	7	79	theme	irregular	1116:1124	arg1	surface					1126:1132	a more irregular surface	1109:1132	a more irregular surface containing slightly more open tubules	1109:1170	Eroded dentin consisted of a more irregular surface containing slightly more open tubules.
33940669	11	80	with	biomodification	1517:1531	arg1	P-Chi					1568:1572	P-Chi	1568:1572	P-Chi	1568:1572	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	11	80	with	biomodification	1517:1531	arg1	chitosan					1558:1565	2.5% phosphorylated chitosan	1538:1565	2.5% phosphorylated chitosan (P-Chi)	1538:1573	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	6	81	dep	phosphate	985:993	arg1	bands					1041:1045	related bands	1033:1045	related bands	1033:1045	RESULTS Dentin erosion reduced the intensity of the phosphate (1,100 cm⁻¹) and carbonate (872 cm⁻¹) related bands, which evidenced demineralization.
33940669	11	82	theme	2.5	1538:1540	arg1	%					1541:1541	%	1541:1541	%	1541:1541	CLINICAL SIGNIFICANCE Eroded dentin demineralization promoted by biomodification with 2.5% phosphorylated chitosan (P-Chi) is a promising indicator for further studies and highlights the dentin intrinsic characteristics.
33940669	2	83	used	used	327:330	arg2	METHODS					287:293	METHODS	287:293	METHODS 42 bovine dentin specimens	287:320	METHODS 42 bovine dentin specimens were used; 21 of these specimens were subjected to erosive challenge with 0.3% citric acid (pH = 3.2) for 2 hours.
33940669	10	84	theme	substrate	1436:1444	arg1	type					1446:1449	substrate type	1436:1449	substrate type	1436:1449	Biomodified dentin had a more irregular surface, irrespective of substrate type.
33940669	3	85	dep	EDC	590:592	arg1	mol/L					584:588	mol/L	584:588	mol/L	584:588	The specimens were randomly divided into six groups according to dentin substrate (sound or eroded) and biomodification [with 2.5% P-Chi, with 0.5 mol/L EDC, or no biomodification (control)].
33357909	0	0	theme	graphene	78:85	arg1	oxide					87:91	graphene oxide	78:91	graphene oxide	78:91	Preparation and properties of composite cellulose fibres with the addition of graphene oxide.
33357909	2	1	from	nano-addition	384:396	arg1	N					418:418	N	418:418	N	418:418	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	2	1	from	nano-addition	384:396	arg1	N-dimethylformamide					420:438	N-dimethylformamide	420:438	N-dimethylformamide (DMF)	420:444	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	2	2	theme	CEL	305:307	arg1	solutions					309:317	CEL solutions	305:317	CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF)	305:444	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	5	3	theme	additive	650:657	arg1	type					667:670	the type	663:670	the type of coagulant	663:683	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	5	3	theme	additive	650:657	arg1	coagulant					675:683	coagulant	675:683	coagulant	675:683	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	5	3	theme	additive	650:657	arg1	amount					637:642	the amount	633:642	the amount of GO additive	633:657	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	5	3	theme	additive	650:657	arg1	additive					650:657	additive	650:657	additive	650:657	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	2	4	from	dispersion	404:413	arg1	N					418:418	N	418:418	N	418:418	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	2	4	from	dispersion	404:413	arg1	N-dimethylformamide					420:438	N-dimethylformamide	420:438	N-dimethylformamide (DMF)	420:444	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	4	5	theme	distilled	573:581	arg1	solvents					563:570	two solvents	559:570	two solvents: distilled water and methanol	559:600	The fibres were coagulated in two solvents: distilled water and methanol.
33357909	4	5	theme	distilled	573:581	arg1	water					583:587	distilled water	573:587	distilled water	573:587	The fibres were coagulated in two solvents: distilled water and methanol.
33357909	6	6	theme	crystallinity	862:874	arg1	degree					852:857	a degree	850:857	a degree of crystallinity of 31.0-40.8 % (WAXS)	850:896	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	6	6	theme	crystallinity	862:874	arg1	shift					904:908	a shift	902:908	a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA)	902:1008	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	6	7	theme	%	889:889	arg1	degree					852:857	a degree	850:857	a degree of crystallinity of 31.0-40.8 % (WAXS)	850:896	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	6	7	theme	%	889:889	arg1	shift					904:908	a shift	902:908	a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA)	902:1008	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	3	8	theme	fibres	480:485	arg1	w					526:526	0, 0.21, 0.50, 0.98, and 1.97 % w w	492:526	0, 0.21, 0.50, 0.98, and 1.97 % w w	492:526	The GO contents of the composite fibres were 0, 0.21, 0.50, 0.98, and 1.97 % w w.
33357909	3	8	theme	fibres	480:485	arg1	contents					454:461	The GO contents	447:461	The GO contents of the composite fibres	447:485	The GO contents of the composite fibres were 0, 0.21, 0.50, 0.98, and 1.97 % w w.
33357909	6	9	theme	higher	984:989	arg1	TGA					1005:1007	TGA	1005:1007	TGA	1005:1007	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	6	9	theme	higher	984:989	arg1	temperatures					991:1002	higher temperatures	984:1002	higher temperatures (TGA)	984:1008	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	0	10	theme	oxide	87:91	arg1	addition					66:73	the addition	62:73	the addition of graphene oxide	62:91	Preparation and properties of composite cellulose fibres with the addition of graphene oxide.
33357909	2	11	from	N	418:418	arg1	nano-addition					384:396	a nano-addition	382:396	a nano-addition of GO dispersion in N,N-dimethylformamide (DMF)	382:444	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	8	12	theme	GO/CEL	1162:1167	arg1	fibres					1169:1174	the GO/CEL fibres	1158:1174	the GO/CEL fibres	1158:1174	In addition, the GO/CEL fibres exhibit satisfactory GO dispersion throughout their volume.
33357909	7	13	theme	fibres	1091:1096	arg1	properties					1066:1075	the mechanical properties	1051:1075	the mechanical properties of the GO/CEL fibres	1051:1096	The results demonstrate improvements in the mechanical properties of the GO/CEL fibres, which were at the level of 9.43-14.18 cN/tex.
33357909	5	14	theme	GO/CEL	779:784	arg1	fibres					786:791	the CEL and GO/CEL fibres	767:791	fibres	786:791	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	5	15	theme	coagulant	675:683	arg1	type					667:670	the type	663:670	the type of coagulant	663:683	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	5	15	theme	coagulant	675:683	arg1	coagulant					675:683	coagulant	675:683	coagulant	675:683	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	5	15	theme	coagulant	675:683	arg1	amount					637:642	the amount	633:642	the amount of GO additive	633:657	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	5	15	theme	coagulant	675:683	arg1	additive					650:657	additive	650:657	additive	650:657	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	8	16	theme	satisfactory	1184:1195	arg1	dispersion					1200:1209	satisfactory GO dispersion	1184:1209	satisfactory GO dispersion	1184:1209	In addition, the GO/CEL fibres exhibit satisfactory GO dispersion throughout their volume.
33357909	5	17	theme	structural	742:751	arg1	properties					753:762	the physicochemical, mechanical and structural properties	706:762	the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres	706:791	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	6	18	from	degree	852:857	arg1	temperature					939:949	the thermal decomposition temperature	913:949	the thermal decomposition temperature (by approximately 19 °C)	913:974	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	1	19	from	results	117:123	arg1	preparation					143:153	the preparation	139:153	the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO)	139:229	The paper presents the results of a study on the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO).
33357909	2	20	theme	Composite	232:240	arg1	GO/CEL					250:255	GO/CEL	250:255	GO/CEL	250:255	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	2	20	theme	Composite	232:240	arg1	fibres					242:247	Composite fibres	232:247	Composite fibres (GO/CEL)	232:256	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	6	21	theme	thermal	917:923	arg1	temperature					939:949	the thermal decomposition temperature	913:949	the thermal decomposition temperature (by approximately 19 °C)	913:974	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	2	22	theme	dispersion	404:413	arg1	nano-addition					384:396	a nano-addition	382:396	a nano-addition of GO dispersion in N,N-dimethylformamide (DMF)	382:444	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	6	23	from	use	798:800	arg1	bath					838:841	a coagulation bath	824:841	a coagulation bath	824:841	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	2	24	dep	dispersion	404:413	arg1	GO					401:402	GO	401:402	GO	401:402	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	1	25	theme	cellulose-based	158:172	arg1	CEL					192:194	CEL	192:194	CEL	192:194	The paper presents the results of a study on the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO).
33357909	1	25	theme	cellulose-based	158:172	arg1	fibres					184:189	cellulose-based composite fibres	158:189	cellulose-based composite fibres (CEL) with graphene oxide addition (GO)	158:229	The paper presents the results of a study on the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO).
33357909	6	26	from	shift	904:908	arg1	temperature					939:949	the thermal decomposition temperature	913:949	the thermal decomposition temperature (by approximately 19 °C)	913:974	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	8	27	theme	GO	1197:1198	arg1	dispersion					1200:1209	satisfactory GO dispersion	1184:1209	satisfactory GO dispersion	1184:1209	In addition, the GO/CEL fibres exhibit satisfactory GO dispersion throughout their volume.
33357909	2	28	theme	1-ethyl-3-methylimidazolium	322:348	arg1	EMIMAc					359:364	EMIMAc	359:364	EMIMAc	359:364	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	2	28	theme	1-ethyl-3-methylimidazolium	322:348	arg1	acetate					350:356	1-ethyl-3-methylimidazolium acetate	322:356	1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF)	322:444	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	5	29	theme	mechanical	727:736	arg1	properties					753:762	the physicochemical, mechanical and structural properties	706:762	the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres	706:791	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	2	30	from	solutions	309:317	arg1	EMIMAc					359:364	EMIMAc	359:364	EMIMAc	359:364	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	2	30	from	solutions	309:317	arg1	acetate					350:356	1-ethyl-3-methylimidazolium acetate	322:356	1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF)	322:444	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	3	31	dep	contents	454:461	arg1	GO					451:452	GO	451:452	GO	451:452	The GO contents of the composite fibres were 0, 0.21, 0.50, 0.98, and 1.97 % w w.
33357909	1	32	theme	fibres	184:189	arg1	preparation					143:153	the preparation	139:153	the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO)	139:229	The paper presents the results of a study on the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO).
33357909	5	33	dep	additive	650:657	arg1	GO					647:648	GO	647:648	GO	647:648	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	5	34	theme	fibres	786:791	arg1	properties					753:762	the physicochemical, mechanical and structural properties	706:762	the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres	706:791	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	0	35	theme	cellulose	40:48	arg1	fibres					50:55	composite cellulose fibres	30:55	composite cellulose fibres	30:55	Preparation and properties of composite cellulose fibres with the addition of graphene oxide.
33357909	6	36	theme	coagulation	826:836	arg1	bath					838:841	a coagulation bath	824:841	a coagulation bath	824:841	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	1	37	with	fibres	184:189	arg1	addition					217:224	graphene oxide addition	202:224	graphene oxide addition (GO)	202:229	The paper presents the results of a study on the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO).
33357909	1	38	dep	addition	217:224	arg1	GO					227:228	GO	227:228	GO	227:228	The paper presents the results of a study on the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO).
33357909	1	39	theme	composite	174:182	arg1	CEL					192:194	CEL	192:194	CEL	192:194	The paper presents the results of a study on the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO).
33357909	1	39	theme	composite	174:182	arg1	fibres					184:189	cellulose-based composite fibres	158:189	cellulose-based composite fibres (CEL) with graphene oxide addition (GO)	158:229	The paper presents the results of a study on the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO).
33357909	3	40	dep	%	522:522	arg1	0.98					507:510	0.98	507:510	0.98	507:510	The GO contents of the composite fibres were 0, 0.21, 0.50, 0.98, and 1.97 % w w.
33357909	3	40	dep	%	522:522	arg1	1.97					517:520	1.97	517:520	1.97	517:520	The GO contents of the composite fibres were 0, 0.21, 0.50, 0.98, and 1.97 % w w.
33357909	0	41	theme	composite	30:38	arg1	fibres					50:55	composite cellulose fibres	30:55	composite cellulose fibres	30:55	Preparation and properties of composite cellulose fibres with the addition of graphene oxide.
33357909	4	42	dep	solvents	563:570	arg1	methanol					593:600	methanol	593:600	methanol	593:600	The fibres were coagulated in two solvents: distilled water and methanol.
33357909	4	42	dep	solvents	563:570	arg1	solvents					563:570	two solvents	559:570	two solvents: distilled water and methanol	559:600	The fibres were coagulated in two solvents: distilled water and methanol.
33357909	4	42	dep	solvents	563:570	arg1	water					583:587	distilled water	573:587	distilled water	573:587	The fibres were coagulated in two solvents: distilled water and methanol.
33357909	6	43	theme	decomposition	925:937	arg1	temperature					939:949	the thermal decomposition temperature	913:949	the thermal decomposition temperature (by approximately 19 °C)	913:974	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	0	44	with	properties	16:25	arg1	addition					66:73	the addition	62:73	the addition of graphene oxide	62:91	Preparation and properties of composite cellulose fibres with the addition of graphene oxide.
33357909	0	45	theme	fibres	50:55	arg1	properties					16:25	properties	16:25	properties	16:25	Preparation and properties of composite cellulose fibres with the addition of graphene oxide.
33357909	0	45	theme	fibres	50:55	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and properties of composite cellulose fibres with the addition of graphene oxide.
33357909	6	46	theme	water	815:819	arg1	use					798:800	The use	794:800	The use of distilled water in a coagulation bath	794:841	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	2	47	theme	spinning	284:291	arg1	method					293:298	the wet spinning method	276:298	the wet spinning method	276:298	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	6	48	theme	distilled	805:813	arg1	water					815:819	distilled water	805:819	distilled water	805:819	The use of distilled water in a coagulation bath causes a degree of crystallinity of 31.0-40.8 % (WAXS) and a shift in the thermal decomposition temperature (by approximately 19 °C) towards higher temperatures (TGA).
33357909	7	49	from	improvements	1035:1046	arg1	properties					1066:1075	the mechanical properties	1051:1075	the mechanical properties of the GO/CEL fibres	1051:1096	The results demonstrate improvements in the mechanical properties of the GO/CEL fibres, which were at the level of 9.43-14.18 cN/tex.
33357909	0	50	with	Preparation	0:10	arg1	addition					66:73	the addition	62:73	the addition of graphene oxide	62:91	Preparation and properties of composite cellulose fibres with the addition of graphene oxide.
33357909	2	51	theme	wet	280:282	arg1	method					293:298	the wet spinning method	276:298	the wet spinning method	276:298	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	3	52	dep	w	526:526	arg1	%					522:522	%	522:522	%	522:522	The GO contents of the composite fibres were 0, 0.21, 0.50, 0.98, and 1.97 % w w.
33357909	3	53	theme	composite	470:478	arg1	fibres					480:485	the composite fibres	466:485	the composite fibres	466:485	The GO contents of the composite fibres were 0, 0.21, 0.50, 0.98, and 1.97 % w w.
33357909	2	54	contain	contained	372:380	arg2	nano-addition					384:396	a nano-addition	382:396	a nano-addition of GO dispersion in N,N-dimethylformamide (DMF)	382:444	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	2	54	contain	contained	372:380	arg1	EMIMAc					359:364	EMIMAc	359:364	EMIMAc	359:364	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	2	54	contain	contained	372:380	arg1	acetate					350:356	1-ethyl-3-methylimidazolium acetate	322:356	1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF)	322:444	Composite fibres (GO/CEL) were prepared via the wet spinning method from CEL solutions in 1-ethyl-3-methylimidazolium acetate (EMIMAc) that contained a nano-addition of GO dispersion in N,N-dimethylformamide (DMF).
33357909	3	55	theme	w	524:524	arg1	w					526:526	0, 0.21, 0.50, 0.98, and 1.97 % w w	492:526	0, 0.21, 0.50, 0.98, and 1.97 % w w	492:526	The GO contents of the composite fibres were 0, 0.21, 0.50, 0.98, and 1.97 % w w.
33357909	3	55	theme	w	524:524	arg1	contents					454:461	The GO contents	447:461	The GO contents of the composite fibres	447:485	The GO contents of the composite fibres were 0, 0.21, 0.50, 0.98, and 1.97 % w w.
33357909	7	56	theme	mechanical	1055:1064	arg1	properties					1066:1075	the mechanical properties	1051:1075	the mechanical properties of the GO/CEL fibres	1051:1096	The results demonstrate improvements in the mechanical properties of the GO/CEL fibres, which were at the level of 9.43-14.18 cN/tex.
33357909	1	57	theme	graphene	202:209	arg1	addition					217:224	graphene oxide addition	202:224	graphene oxide addition (GO)	202:229	The paper presents the results of a study on the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO).
33357909	5	58	theme	physicochemical	710:724	arg1	properties					753:762	the physicochemical, mechanical and structural properties	706:762	the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres	706:791	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	5	59	theme	CEL	771:773	arg1	fibres					786:791	the CEL and GO/CEL fibres	767:791	fibres	786:791	The results demonstrated that the amount of GO additive and the type of coagulant significantly impact the physicochemical, mechanical and structural properties of the CEL and GO/CEL fibres.
33357909	7	60	theme	cN/tex	1137:1142	arg1	level					1117:1121	the level	1113:1121	the level of 9.43-14.18 cN/tex	1113:1142	The results demonstrate improvements in the mechanical properties of the GO/CEL fibres, which were at the level of 9.43-14.18 cN/tex.
33357909	1	61	theme	oxide	211:215	arg1	addition					217:224	graphene oxide addition	202:224	graphene oxide addition (GO)	202:229	The paper presents the results of a study on the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO).
33357909	1	62	theme	study	130:134	arg1	results					117:123	the results	113:123	the results of a study on the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO)	113:229	The paper presents the results of a study on the preparation of cellulose-based composite fibres (CEL) with graphene oxide addition (GO).
33357909	7	63	theme	GO/CEL	1084:1089	arg1	fibres					1091:1096	the GO/CEL fibres	1080:1096	the GO/CEL fibres	1080:1096	The results demonstrate improvements in the mechanical properties of the GO/CEL fibres, which were at the level of 9.43-14.18 cN/tex.
32612952	4	0	theme	cancer	633:638	arg1	types					624:628	different types	614:628	different types of cancer	614:638	Bisecting GlcNAc levels were commonly dysregulated in different types of cancer.
32612952	5	1	theme	microarray	697:706	arg1	analysis					708:715	lectin microarray analysis	690:715	lectin microarray analysis	690:715	In this study, we utilized mass spectrometry and lectin microarray analysis to investigate aberrant N-glycans in breast cancer cells.
32612952	6	2	theme	breast	874:879	arg1	cells					888:892	breast cancer cells	874:892	breast cancer cells	874:892	Our data showed the decreased levels of bisecting GlcNAc and down-regulated expression of MGAT3 in breast cancer cells than normal epithelial cells.
32612952	9	3	from	MGAT3	1335:1339	arg1	cells					1369:1373	breast cancer MDA-MB-231 cells	1344:1373	breast cancer MDA-MB-231 cells	1344:1373	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	10	4	theme	malignant	1670:1678	arg1	phenotype					1680:1688	malignant phenotype	1670:1688	malignant phenotype of breast cancer	1670:1705	Taken together, we conclude that bisecting N-GlcNAc on EGFR inhibits malignant phenotype of breast cancer via down-regulation of EGFR/Erk signaling.
32612952	6	5	theme	MGAT3	865:869	arg1	levels					805:810	the decreased levels	791:810	the decreased levels of bisecting GlcNAc	791:830	Our data showed the decreased levels of bisecting GlcNAc and down-regulated expression of MGAT3 in breast cancer cells than normal epithelial cells.
32612952	6	5	theme	MGAT3	865:869	arg1	expression					851:860	down-regulated expression	836:860	down-regulated expression of MGAT3 in breast cancer cells	836:892	Our data showed the decreased levels of bisecting GlcNAc and down-regulated expression of MGAT3 in breast cancer cells than normal epithelial cells.
32612952	8	6	theme	cancer	1251:1256	arg1	cells					1258:1262	breast cancer cells	1244:1262	breast cancer cells	1244:1262	Among the differentially expressed glycoproteins, levels of bisecting GlcNAc on EGFR were significantly decreased in breast cancer cells, confirmed by immunostaining and immunoprecipitation.
32612952	5	7	theme	mass	668:671	arg1	spectrometry					673:684	mass spectrometry	668:684	mass spectrometry	668:684	In this study, we utilized mass spectrometry and lectin microarray analysis to investigate aberrant N-glycans in breast cancer cells.
32612952	9	8	theme	migratory	1540:1548	arg1	ability					1550:1556	migratory ability	1540:1556	migratory ability	1540:1556	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	5	9	theme	aberrant	732:739	arg1	N-glycans					741:749	aberrant N-glycans	732:749	aberrant N-glycans in breast cancer cells	732:772	In this study, we utilized mass spectrometry and lectin microarray analysis to investigate aberrant N-glycans in breast cancer cells.
32612952	10	10	theme	cancer	1700:1705	arg1	phenotype					1680:1688	malignant phenotype	1670:1688	malignant phenotype of breast cancer	1670:1705	Taken together, we conclude that bisecting N-GlcNAc on EGFR inhibits malignant phenotype of breast cancer via down-regulation of EGFR/Erk signaling.
32612952	2	11	theme	breast	343:348	arg1	progression					357:367	breast cancer progression	343:367	breast cancer progression	343:367	Alteration of N-glycan has been detected during breast cancer progression.
32612952	7	12	dep	lectin	945:950	arg1	recognizing					952:962	recognizing	952:962	recognizing	952:962	Using PHA-E (a plant lectin recognizing and combining bisecting GlcNAc) based enrichment coupled with nanoLC-MS/MS, we analyzed the glycoproteins bearing bisecting GlcNAc in various breast cancer cells.
32612952	7	12	dep	lectin	945:950	arg1	combining					968:976	combining	968:976	combining bisecting GlcNAc	968:993	Using PHA-E (a plant lectin recognizing and combining bisecting GlcNAc) based enrichment coupled with nanoLC-MS/MS, we analyzed the glycoproteins bearing bisecting GlcNAc in various breast cancer cells.
32612952	5	13	theme	cancer	761:766	arg1	cells					768:772	breast cancer cells	754:772	breast cancer cells	754:772	In this study, we utilized mass spectrometry and lectin microarray analysis to investigate aberrant N-glycans in breast cancer cells.
32612952	1	14	theme	crucial	223:229	arg1	roles					242:246	crucial biological roles	223:246	crucial biological roles	223:246	Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events.
32612952	10	15	theme	EGFR/Erk	1730:1737	arg1	signaling					1739:1747	EGFR/Erk signaling	1730:1747	EGFR/Erk signaling	1730:1747	Taken together, we conclude that bisecting N-GlcNAc on EGFR inhibits malignant phenotype of breast cancer via down-regulation of EGFR/Erk signaling.
32612952	7	16	theme	bisecting	1078:1086	arg1	GlcNAc					1088:1093	bisecting GlcNAc	1078:1093	bisecting GlcNAc	1078:1093	Using PHA-E (a plant lectin recognizing and combining bisecting GlcNAc) based enrichment coupled with nanoLC-MS/MS, we analyzed the glycoproteins bearing bisecting GlcNAc in various breast cancer cells.
32612952	7	17	theme	cancer	1113:1118	arg1	cells					1120:1124	various breast cancer cells	1098:1124	various breast cancer cells	1098:1124	Using PHA-E (a plant lectin recognizing and combining bisecting GlcNAc) based enrichment coupled with nanoLC-MS/MS, we analyzed the glycoproteins bearing bisecting GlcNAc in various breast cancer cells.
32612952	9	18	theme	breast	1344:1349	arg1	cells					1369:1373	breast cancer MDA-MB-231 cells	1344:1373	breast cancer MDA-MB-231 cells	1344:1373	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	3	19	link	β1,4-linked	454:464	arg1	GlcNAc					466:471	a β1,4-linked GlcNAc	452:471	a β1,4-linked GlcNAc attached to the core β-mannose residue	452:510	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	3	19	link	β1,4-linked	454:464	arg1	N-Acetylglucosamine					420:438	bisecting N-Acetylglucosamine	410:438	bisecting N-Acetylglucosamine (GlcNAc)	410:447	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	9	20	theme	formation	1590:1598	arg1	reduction					1527:1535	the reduction	1523:1535	the reduction of migratory ability, cell proliferation, and clonal formation	1523:1598	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	7	21	theme	various	1098:1104	arg1	cells					1120:1124	various breast cancer cells	1098:1124	various breast cancer cells	1098:1124	Using PHA-E (a plant lectin recognizing and combining bisecting GlcNAc) based enrichment coupled with nanoLC-MS/MS, we analyzed the glycoproteins bearing bisecting GlcNAc in various breast cancer cells.
32612952	9	22	theme	MDA-MB-231	1358:1367	arg1	cells					1369:1373	breast cancer MDA-MB-231 cells	1344:1373	breast cancer MDA-MB-231 cells	1344:1373	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	0	23	theme	Breast	70:75	arg1	Cancer					77:82	Breast Cancer	70:82	Breast Cancer	70:82	Bisecting N-Acetylglucosamine on EGFR Inhibits Malignant Phenotype of Breast Cancer via Down-Regulation of EGFR/Erk Signaling.
32612952	1	24	theme	post-translational	173:190	arg1	modification					192:203	the most prevalent and diverse post-translational modification	142:203	the most prevalent and diverse post-translational modification of protein	142:214	Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events.
32612952	1	24	theme	post-translational	173:190	arg1	Glycosylation					127:139	Glycosylation	127:139	Glycosylation	127:139	Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events.
32612952	7	25	dep	based	996:1000	arg1	lectin					945:950	a plant lectin	937:950	a plant lectin recognizing and combining bisecting GlcNAc	937:993	Using PHA-E (a plant lectin recognizing and combining bisecting GlcNAc) based enrichment coupled with nanoLC-MS/MS, we analyzed the glycoproteins bearing bisecting GlcNAc in various breast cancer cells.
32612952	9	26	theme	MGAT3	1398:1402	arg1	overexpression					1380:1393	overexpression	1380:1393	overexpression of MGAT3	1380:1402	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	8	27	from	levels	1177:1182	arg1	EGFR					1207:1210	EGFR	1207:1210	EGFR	1207:1210	Among the differentially expressed glycoproteins, levels of bisecting GlcNAc on EGFR were significantly decreased in breast cancer cells, confirmed by immunostaining and immunoprecipitation.
32612952	3	28	theme	specific	380:387	arg1	structures					398:407	the specific N-glycan structures	376:407	the specific N-glycan structures	376:407	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	0	29	theme	Signaling	116:124	arg1	Down-Regulation					88:102	Down-Regulation	88:102	Down-Regulation of EGFR/Erk Signaling	88:124	Bisecting N-Acetylglucosamine on EGFR Inhibits Malignant Phenotype of Breast Cancer via Down-Regulation of EGFR/Erk Signaling.
32612952	0	30	theme	Bisecting	0:8	arg1	N-Acetylglucosamine					10:28	Bisecting N-Acetylglucosamine	0:28	Bisecting N-Acetylglucosamine on EGFR	0:36	Bisecting N-Acetylglucosamine on EGFR Inhibits Malignant Phenotype of Breast Cancer via Down-Regulation of EGFR/Erk Signaling.
32612952	9	31	theme	bisecting	1431:1439	arg1	N-GlcNAc					1441:1448	the bisecting N-GlcNAc	1427:1448	the bisecting N-GlcNAc on EGFR	1427:1456	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	9	32	from	N-GlcNAc	1441:1448	arg1	EGFR					1453:1456	EGFR	1453:1456	EGFR	1453:1456	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	7	33	theme	bisecting	978:986	arg1	GlcNAc					988:993	bisecting GlcNAc	978:993	bisecting GlcNAc	978:993	Using PHA-E (a plant lectin recognizing and combining bisecting GlcNAc) based enrichment coupled with nanoLC-MS/MS, we analyzed the glycoproteins bearing bisecting GlcNAc in various breast cancer cells.
32612952	3	34	theme	bisecting	410:418	arg1	GlcNAc					466:471	a β1,4-linked GlcNAc	452:471	a β1,4-linked GlcNAc attached to the core β-mannose residue	452:510	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	3	34	theme	bisecting	410:418	arg1	GlcNAc					441:446	GlcNAc	441:446	GlcNAc	441:446	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	3	34	theme	bisecting	410:418	arg1	N-Acetylglucosamine					420:438	bisecting N-Acetylglucosamine	410:438	bisecting N-Acetylglucosamine (GlcNAc)	410:447	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	4	35	theme	different	614:622	arg1	types					624:628	different types	614:628	different types of cancer	614:638	Bisecting GlcNAc levels were commonly dysregulated in different types of cancer.
32612952	3	36	theme	core	489:492	arg1	residue					504:510	the core β-mannose residue	485:510	the core β-mannose residue	485:510	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	8	37	from	EGFR	1207:1210	arg1	levels					1177:1182	levels	1177:1182	levels of bisecting GlcNAc on EGFR	1177:1210	Among the differentially expressed glycoproteins, levels of bisecting GlcNAc on EGFR were significantly decreased in breast cancer cells, confirmed by immunostaining and immunoprecipitation.
32612952	4	38	theme	GlcNAc	570:575	arg1	levels					577:582	Bisecting GlcNAc levels	560:582	Bisecting GlcNAc levels	560:582	Bisecting GlcNAc levels were commonly dysregulated in different types of cancer.
32612952	6	39	theme	normal	899:904	arg1	cells					917:921	normal epithelial cells	899:921	normal epithelial cells	899:921	Our data showed the decreased levels of bisecting GlcNAc and down-regulated expression of MGAT3 in breast cancer cells than normal epithelial cells.
32612952	7	40	gly	glycoproteins	1056:1068	arg1	glycoproteins					1056:1068	the glycoproteins	1052:1068	the glycoproteins bearing bisecting GlcNAc in various breast cancer cells	1052:1124	Using PHA-E (a plant lectin recognizing and combining bisecting GlcNAc) based enrichment coupled with nanoLC-MS/MS, we analyzed the glycoproteins bearing bisecting GlcNAc in various breast cancer cells.
32612952	6	41	theme	decreased	795:803	arg1	levels					805:810	the decreased levels	791:810	the decreased levels of bisecting GlcNAc	791:830	Our data showed the decreased levels of bisecting GlcNAc and down-regulated expression of MGAT3 in breast cancer cells than normal epithelial cells.
32612952	5	42	from	N-glycans	741:749	arg1	cells					768:772	breast cancer cells	754:772	breast cancer cells	754:772	In this study, we utilized mass spectrometry and lectin microarray analysis to investigate aberrant N-glycans in breast cancer cells.
32612952	8	43	theme	bisecting	1187:1195	arg1	GlcNAc					1197:1202	bisecting GlcNAc	1187:1202	bisecting GlcNAc on EGFR	1187:1210	Among the differentially expressed glycoproteins, levels of bisecting GlcNAc on EGFR were significantly decreased in breast cancer cells, confirmed by immunostaining and immunoprecipitation.
32612952	1	44	theme	physiological	256:268	arg1	events					287:292	many physiological and pathological events	251:292	many physiological and pathological events	251:292	Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events.
32612952	10	45	theme	bisecting	1634:1642	arg1	N-GlcNAc					1644:1651	bisecting N-GlcNAc	1634:1651	bisecting N-GlcNAc on EGFR	1634:1659	Taken together, we conclude that bisecting N-GlcNAc on EGFR inhibits malignant phenotype of breast cancer via down-regulation of EGFR/Erk signaling.
32612952	5	46	theme	lectin	690:695	arg1	analysis					708:715	lectin microarray analysis	690:715	lectin microarray analysis	690:715	In this study, we utilized mass spectrometry and lectin microarray analysis to investigate aberrant N-glycans in breast cancer cells.
32612952	3	47	theme	glycosyltransferase	533:551	arg1	MGAT3					553:557	glycosyltransferase MGAT3	533:557	glycosyltransferase MGAT3	533:557	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	7	48	theme	plant	939:943	arg1	lectin					945:950	a plant lectin	937:950	a plant lectin recognizing and combining bisecting GlcNAc	937:993	Using PHA-E (a plant lectin recognizing and combining bisecting GlcNAc) based enrichment coupled with nanoLC-MS/MS, we analyzed the glycoproteins bearing bisecting GlcNAc in various breast cancer cells.
32612952	1	49	theme	pathological	274:285	arg1	events					287:292	many physiological and pathological events	251:292	many physiological and pathological events	251:292	Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events.
32612952	5	50	used	utilized	659:666	arg2	we					656:657	we	656:657	we	656:657	In this study, we utilized mass spectrometry and lectin microarray analysis to investigate aberrant N-glycans in breast cancer cells.
32612952	10	51	from	N-GlcNAc	1644:1651	arg1	EGFR					1656:1659	EGFR	1656:1659	EGFR	1656:1659	Taken together, we conclude that bisecting N-GlcNAc on EGFR inhibits malignant phenotype of breast cancer via down-regulation of EGFR/Erk signaling.
32612952	2	52	theme	N-glycan	309:316	arg1	Alteration					295:304	Alteration	295:304	Alteration of N-glycan	295:316	Alteration of N-glycan has been detected during breast cancer progression.
32612952	1	53	theme	protein	208:214	arg1	modification					192:203	the most prevalent and diverse post-translational modification	142:203	the most prevalent and diverse post-translational modification of protein	142:214	Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events.
32612952	1	53	theme	protein	208:214	arg1	Glycosylation					127:139	Glycosylation	127:139	Glycosylation	127:139	Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events.
32612952	8	54	theme	breast	1244:1249	arg1	cells					1258:1262	breast cancer cells	1244:1262	breast cancer cells	1244:1262	Among the differentially expressed glycoproteins, levels of bisecting GlcNAc on EGFR were significantly decreased in breast cancer cells, confirmed by immunostaining and immunoprecipitation.
32612952	6	55	theme	down-regulated	836:849	arg1	expression					851:860	down-regulated expression	836:860	down-regulated expression of MGAT3 in breast cancer cells	836:892	Our data showed the decreased levels of bisecting GlcNAc and down-regulated expression of MGAT3 in breast cancer cells than normal epithelial cells.
32612952	2	56	theme	cancer	350:355	arg1	progression					357:367	breast cancer progression	343:367	breast cancer progression	343:367	Alteration of N-glycan has been detected during breast cancer progression.
32612952	9	57	theme	ability	1550:1556	arg1	reduction					1527:1535	the reduction	1523:1535	the reduction of migratory ability, cell proliferation, and clonal formation	1523:1598	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	4	58	theme	Bisecting	560:568	arg1	levels					577:582	Bisecting GlcNAc levels	560:582	Bisecting GlcNAc levels	560:582	Bisecting GlcNAc levels were commonly dysregulated in different types of cancer.
32612952	3	59	attach	attached	473:480	arg2	GlcNAc					466:471	a β1,4-linked GlcNAc	452:471	a β1,4-linked GlcNAc attached to the core β-mannose residue	452:510	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	3	59	attach	attached	473:480	arg1	residue					504:510	the core β-mannose residue	485:510	the core β-mannose residue	485:510	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	3	59	attach	attached	473:480	arg2	N-Acetylglucosamine					420:438	bisecting N-Acetylglucosamine	410:438	bisecting N-Acetylglucosamine (GlcNAc)	410:447	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	10	60	theme	breast	1693:1698	arg1	cancer					1700:1705	breast cancer	1693:1705	breast cancer	1693:1705	Taken together, we conclude that bisecting N-GlcNAc on EGFR inhibits malignant phenotype of breast cancer via down-regulation of EGFR/Erk signaling.
32612952	5	61	theme	breast	754:759	arg1	cells					768:772	breast cancer cells	754:772	breast cancer cells	754:772	In this study, we utilized mass spectrometry and lectin microarray analysis to investigate aberrant N-glycans in breast cancer cells.
32612952	6	62	theme	GlcNAc	825:830	arg1	levels					805:810	the decreased levels	791:810	the decreased levels of bisecting GlcNAc	791:830	Our data showed the decreased levels of bisecting GlcNAc and down-regulated expression of MGAT3 in breast cancer cells than normal epithelial cells.
32612952	6	62	theme	GlcNAc	825:830	arg1	expression					851:860	down-regulated expression	836:860	down-regulated expression of MGAT3 in breast cancer cells	836:892	Our data showed the decreased levels of bisecting GlcNAc and down-regulated expression of MGAT3 in breast cancer cells than normal epithelial cells.
32612952	9	63	theme	cell	1559:1562	arg1	proliferation					1564:1576	cell proliferation	1559:1576	cell proliferation	1559:1576	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	10	64	theme	signaling	1739:1747	arg1	down-regulation					1711:1725	down-regulation	1711:1725	down-regulation of EGFR/Erk signaling	1711:1747	Taken together, we conclude that bisecting N-GlcNAc on EGFR inhibits malignant phenotype of breast cancer via down-regulation of EGFR/Erk signaling.
32612952	1	65	theme	biological	231:240	arg1	roles					242:246	crucial biological roles	223:246	crucial biological roles	223:246	Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events.
32612952	7	66	theme	breast	1106:1111	arg1	cells					1120:1124	various breast cancer cells	1098:1124	various breast cancer cells	1098:1124	Using PHA-E (a plant lectin recognizing and combining bisecting GlcNAc) based enrichment coupled with nanoLC-MS/MS, we analyzed the glycoproteins bearing bisecting GlcNAc in various breast cancer cells.
32612952	9	67	theme	clonal	1583:1588	arg1	formation					1590:1598	clonal formation	1583:1598	clonal formation	1583:1598	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	9	68	theme	cancer	1351:1356	arg1	cells					1369:1373	breast cancer MDA-MB-231 cells	1344:1373	breast cancer MDA-MB-231 cells	1344:1373	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	0	69	theme	Cancer	77:82	arg1	Phenotype					57:65	Malignant Phenotype	47:65	Malignant Phenotype of Breast Cancer	47:82	Bisecting N-Acetylglucosamine on EGFR Inhibits Malignant Phenotype of Breast Cancer via Down-Regulation of EGFR/Erk Signaling.
32612952	1	70	theme	prevalent	151:159	arg1	modification					192:203	the most prevalent and diverse post-translational modification	142:203	the most prevalent and diverse post-translational modification of protein	142:214	Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events.
32612952	1	70	theme	prevalent	151:159	arg1	Glycosylation					127:139	Glycosylation	127:139	Glycosylation	127:139	Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events.
32612952	1	71	theme	diverse	165:171	arg1	modification					192:203	the most prevalent and diverse post-translational modification	142:203	the most prevalent and diverse post-translational modification of protein	142:214	Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events.
32612952	1	71	theme	diverse	165:171	arg1	Glycosylation					127:139	Glycosylation	127:139	Glycosylation	127:139	Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events.
32612952	8	72	from	GlcNAc	1197:1202	arg1	EGFR					1207:1210	EGFR	1207:1210	EGFR	1207:1210	Among the differentially expressed glycoproteins, levels of bisecting GlcNAc on EGFR were significantly decreased in breast cancer cells, confirmed by immunostaining and immunoprecipitation.
32612952	0	73	from	N-Acetylglucosamine	10:28	arg1	EGFR					33:36	EGFR	33:36	EGFR	33:36	Bisecting N-Acetylglucosamine on EGFR Inhibits Malignant Phenotype of Breast Cancer via Down-Regulation of EGFR/Erk Signaling.
32612952	0	74	theme	EGFR/Erk	107:114	arg1	Signaling					116:124	EGFR/Erk Signaling	107:124	EGFR/Erk Signaling	107:124	Bisecting N-Acetylglucosamine on EGFR Inhibits Malignant Phenotype of Breast Cancer via Down-Regulation of EGFR/Erk Signaling.
32612952	8	75	dep	decreased	1231:1239	arg1	confirmed					1265:1273	confirmed	1265:1273	confirmed by immunostaining and immunoprecipitation	1265:1315	Among the differentially expressed glycoproteins, levels of bisecting GlcNAc on EGFR were significantly decreased in breast cancer cells, confirmed by immunostaining and immunoprecipitation.
32612952	9	76	theme	proliferation	1564:1576	arg1	reduction					1527:1535	the reduction	1523:1535	the reduction of migratory ability, cell proliferation, and clonal formation	1523:1598	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	3	77	theme	N-glycan	389:396	arg1	structures					398:407	the specific N-glycan structures	376:407	the specific N-glycan structures	376:407	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	8	78	gly	glycoproteins	1162:1174	arg1	glycoproteins					1162:1174	the differentially expressed glycoproteins	1133:1174	the differentially expressed glycoproteins	1133:1174	Among the differentially expressed glycoproteins, levels of bisecting GlcNAc on EGFR were significantly decreased in breast cancer cells, confirmed by immunostaining and immunoprecipitation.
32612952	7	79	theme	based	996:1000	arg1	enrichment					1002:1011	PHA-E (a plant lectin recognizing and combining bisecting GlcNAc) based enrichment	930:1011	PHA-E (a plant lectin recognizing and combining bisecting GlcNAc) based enrichment coupled with nanoLC-MS/MS	930:1037	Using PHA-E (a plant lectin recognizing and combining bisecting GlcNAc) based enrichment coupled with nanoLC-MS/MS, we analyzed the glycoproteins bearing bisecting GlcNAc in various breast cancer cells.
32612952	8	80	theme	expressed	1152:1160	arg1	glycoproteins					1162:1174	the differentially expressed glycoproteins	1133:1174	the differentially expressed glycoproteins	1133:1174	Among the differentially expressed glycoproteins, levels of bisecting GlcNAc on EGFR were significantly decreased in breast cancer cells, confirmed by immunostaining and immunoprecipitation.
32612952	0	81	theme	Malignant	47:55	arg1	Phenotype					57:65	Malignant Phenotype	47:65	Malignant Phenotype of Breast Cancer	47:82	Bisecting N-Acetylglucosamine on EGFR Inhibits Malignant Phenotype of Breast Cancer via Down-Regulation of EGFR/Erk Signaling.
32612952	6	82	from	expression	851:860	arg1	cells					888:892	breast cancer cells	874:892	breast cancer cells	874:892	Our data showed the decreased levels of bisecting GlcNAc and down-regulated expression of MGAT3 in breast cancer cells than normal epithelial cells.
32612952	3	83	theme	β1,4-linked	454:464	arg1	GlcNAc					466:471	a β1,4-linked GlcNAc	452:471	a β1,4-linked GlcNAc attached to the core β-mannose residue	452:510	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	3	83	theme	β1,4-linked	454:464	arg1	N-Acetylglucosamine					420:438	bisecting N-Acetylglucosamine	410:438	bisecting N-Acetylglucosamine (GlcNAc)	410:447	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	6	84	theme	bisecting	815:823	arg1	GlcNAc					825:830	bisecting GlcNAc	815:830	bisecting GlcNAc	815:830	Our data showed the decreased levels of bisecting GlcNAc and down-regulated expression of MGAT3 in breast cancer cells than normal epithelial cells.
32612952	3	85	theme	β-mannose	494:502	arg1	residue					504:510	the core β-mannose residue	485:510	the core β-mannose residue	485:510	Among the specific N-glycan structures, bisecting N-Acetylglucosamine (GlcNAc) is a β1,4-linked GlcNAc attached to the core β-mannose residue, and is catalyzed by glycosyltransferase MGAT3.
32612952	6	86	theme	epithelial	906:915	arg1	cells					917:921	normal epithelial cells	899:921	normal epithelial cells	899:921	Our data showed the decreased levels of bisecting GlcNAc and down-regulated expression of MGAT3 in breast cancer cells than normal epithelial cells.
32612952	6	87	from	levels	805:810	arg1	cells					888:892	breast cancer cells	874:892	breast cancer cells	874:892	Our data showed the decreased levels of bisecting GlcNAc and down-regulated expression of MGAT3 in breast cancer cells than normal epithelial cells.
32612952	9	88	theme	EGFR/Erk	1477:1484	arg1	signaling					1486:1494	the EGFR/Erk signaling	1473:1494	the EGFR/Erk signaling	1473:1494	We overexpressed MGAT3 in breast cancer MDA-MB-231 cells, and overexpression of MGAT3 significantly enhanced the bisecting N-GlcNAc on EGFR and suppressed the EGFR/Erk signaling, which further resulted in the reduction of migratory ability, cell proliferation, and clonal formation.
32612952	8	89	theme	GlcNAc	1197:1202	arg1	levels					1177:1182	levels	1177:1182	levels of bisecting GlcNAc on EGFR	1177:1210	Among the differentially expressed glycoproteins, levels of bisecting GlcNAc on EGFR were significantly decreased in breast cancer cells, confirmed by immunostaining and immunoprecipitation.
32612952	1	90	theme	many	251:254	arg1	events					287:292	many physiological and pathological events	251:292	many physiological and pathological events	251:292	Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events.
32612952	6	91	theme	cancer	881:886	arg1	cells					888:892	breast cancer cells	874:892	breast cancer cells	874:892	Our data showed the decreased levels of bisecting GlcNAc and down-regulated expression of MGAT3 in breast cancer cells than normal epithelial cells.
34251866	6	0	theme	similar	926:932	arg1	affinity					917:924	an affinity	914:924	an affinity similar to other characterized regulatory RBPs	914:971	A purified RBP, RbpB, from Bacteroides thetaiotaomicron binds to single-stranded RNA in vitro with an affinity similar to other characterized regulatory RBPs.
34251866	2	1	theme	nutrient	340:347	arg1	shifts					349:354	nutrient shifts	340:354	nutrient shifts	340:354	Gut microbial species that persist in mammalian hosts for long periods of time must possess mechanisms for sensing and adapting to nutrient shifts to avoid being outcompeted.
34251866	9	2	theme	wild-type	1450:1458	arg1	strain					1460:1465	the wild-type strain	1446:1465	the wild-type strain	1446:1465	The ΔrbpB mutant had reduced expression of BT1871, encoding a predicted RFO-degrading melibiase, compared to the wild-type strain.
34251866	8	3	theme	B.	1202:1203	arg1	mutant					1228:1233	A B. thetaiotaomicron ΔrbpB mutant	1200:1233	A B. thetaiotaomicron ΔrbpB mutant	1200:1233	A B. thetaiotaomicron ΔrbpB mutant shows a growth defect on dietary sugars belonging to the raffinose family of oligosaccharides (RFOs).
34251866	11	4	theme	other	1693:1697	arg1	genes					1722:1726	other polysaccharide-related genes	1693:1726	other polysaccharide-related genes	1693:1726	Our data reveal that RbpB is required for optimal expression of BT1871 and other polysaccharide-related genes, suggesting that we have identified an important new family of global regulatory proteins in the Bacteroidetes.
34251866	6	5	theme	purified	817:824	arg1	RbpB					831:834	RbpB	831:834	RbpB	831:834	A purified RBP, RbpB, from Bacteroides thetaiotaomicron binds to single-stranded RNA in vitro with an affinity similar to other characterized regulatory RBPs.
34251866	6	5	theme	purified	817:824	arg1	RBP					826:828	A purified RBP	815:828	A purified RBP	815:828	A purified RBP, RbpB, from Bacteroides thetaiotaomicron binds to single-stranded RNA in vitro with an affinity similar to other characterized regulatory RBPs.
34251866	8	6	theme	ΔrbpB	1222:1226	arg1	mutant					1228:1233	A B. thetaiotaomicron ΔrbpB mutant	1200:1233	A B. thetaiotaomicron ΔrbpB mutant	1200:1233	A B. thetaiotaomicron ΔrbpB mutant shows a growth defect on dietary sugars belonging to the raffinose family of oligosaccharides (RFOs).
34251866	10	7	theme	RFOs	1588:1591	arg1	raffinose					1593:1601	the RFOs raffinose	1584:1601	the RFOs raffinose	1584:1601	Mutation of BT1871 confirmed that the enzyme it encodes is essential for growth on melibiose and promotes growth on the RFOs raffinose and stachyose.
34251866	11	8	theme	BT1871	1682:1687	arg1	expression					1668:1677	optimal expression	1660:1677	optimal expression of BT1871 and other polysaccharide-related genes	1660:1726	Our data reveal that RbpB is required for optimal expression of BT1871 and other polysaccharide-related genes, suggesting that we have identified an important new family of global regulatory proteins in the Bacteroidetes.
34251866	15	9	dep	regulators	2584:2593	arg1	identified					2603:2612	identified	2603:2612	have identified may be important for life in the host	2598:2650	The ability to turn different carbohydrate utilization genes on and off in response to changing nutrient conditions is critical for Bacteroides to live successfully in the gut, and thus the new regulators we have identified may be important for life in the host.
34251866	2	10	theme	long	267:270	arg1	periods					272:278	long periods	267:278	long periods of time	267:286	Gut microbial species that persist in mammalian hosts for long periods of time must possess mechanisms for sensing and adapting to nutrient shifts to avoid being outcompeted.
34251866	1	11	theme	major	178:182	arg1	driver					184:189	a major driver	176:189	a major driver of these changes	176:206	Human gut microbiome composition is constantly changing, and diet is a major driver of these changes.
34251866	1	11	theme	major	178:182	arg1	diet					168:171	diet	168:171	diet	168:171	Human gut microbiome composition is constantly changing, and diet is a major driver of these changes.
34251866	8	12	from	defect	1250:1255	arg1	sugars					1268:1273	dietary sugars	1260:1273	dietary sugars belonging to the raffinose family of oligosaccharides (RFOs)	1260:1334	A B. thetaiotaomicron ΔrbpB mutant shows a growth defect on dietary sugars belonging to the raffinose family of oligosaccharides (RFOs).
34251866	8	13	theme	raffinose	1292:1300	arg1	family					1302:1307	the raffinose family	1288:1307	the raffinose family of oligosaccharides (RFOs)	1288:1334	A B. thetaiotaomicron ΔrbpB mutant shows a growth defect on dietary sugars belonging to the raffinose family of oligosaccharides (RFOs).
34251866	6	14	from	thetaiotaomicron	854:869	arg1	RbpB					831:834	RbpB	831:834	RbpB	831:834	A purified RBP, RbpB, from Bacteroides thetaiotaomicron binds to single-stranded RNA in vitro with an affinity similar to other characterized regulatory RBPs.
34251866	6	14	from	thetaiotaomicron	854:869	arg1	RBP					826:828	A purified RBP	815:828	A purified RBP	815:828	A purified RBP, RbpB, from Bacteroides thetaiotaomicron binds to single-stranded RNA in vitro with an affinity similar to other characterized regulatory RBPs.
34251866	8	15	theme	growth	1243:1248	arg1	defect					1250:1255	a growth defect	1241:1255	a growth defect on dietary sugars belonging to the raffinose family of oligosaccharides (RFOs)	1241:1334	A B. thetaiotaomicron ΔrbpB mutant shows a growth defect on dietary sugars belonging to the raffinose family of oligosaccharides (RFOs).
34251866	15	16	theme	utilization	2433:2443	arg1	genes					2445:2449	different carbohydrate utilization genes	2410:2449	The ability to turn different carbohydrate utilization genes	2390:2449	The ability to turn different carbohydrate utilization genes on and off in response to changing nutrient conditions is critical for Bacteroides to live successfully in the gut, and thus the new regulators we have identified may be important for life in the host.
34251866	1	17	theme	changes	200:206	arg1	driver					184:189	a major driver	176:189	a major driver of these changes	176:206	Human gut microbiome composition is constantly changing, and diet is a major driver of these changes.
34251866	1	17	theme	changes	200:206	arg1	diet					168:171	diet	168:171	diet	168:171	Human gut microbiome composition is constantly changing, and diet is a major driver of these changes.
34251866	11	18	from	proteins	1809:1816	arg1	Bacteroidetes					1825:1837	the Bacteroidetes	1821:1837	the Bacteroidetes	1821:1837	Our data reveal that RbpB is required for optimal expression of BT1871 and other polysaccharide-related genes, suggesting that we have identified an important new family of global regulatory proteins in the Bacteroidetes.
34251866	15	19	from	live	2537:2540	arg1	gut					2562:2564	the gut	2558:2564	the gut	2558:2564	The ability to turn different carbohydrate utilization genes on and off in response to changing nutrient conditions is critical for Bacteroides to live successfully in the gut, and thus the new regulators we have identified may be important for life in the host.
34251866	15	20	theme	different	2410:2418	arg1	genes					2445:2449	different carbohydrate utilization genes	2410:2449	The ability to turn different carbohydrate utilization genes	2390:2449	The ability to turn different carbohydrate utilization genes on and off in response to changing nutrient conditions is critical for Bacteroides to live successfully in the gut, and thus the new regulators we have identified may be important for life in the host.
34251866	6	21	theme	regulatory	957:966	arg1	RBPs					968:971	other characterized regulatory RBPs	937:971	other characterized regulatory RBPs	937:971	A purified RBP, RbpB, from Bacteroides thetaiotaomicron binds to single-stranded RNA in vitro with an affinity similar to other characterized regulatory RBPs.
34251866	4	22	theme	multiple	722:729	arg1	copies					731:736	multiple copies	722:736	multiple copies	722:736	Here, we report the identification of RBPs that are broadly distributed across the Bacteroidetes, with many genomes encoding multiple copies.
34251866	7	23	theme	capsular	1084:1091	arg1	polysaccharide					1093:1106	capsular polysaccharide	1084:1106	capsular polysaccharide	1084:1106	B. thetaiotaomicron mutants lacking RBPs show dramatic shifts in expression of polysaccharide utilization and capsular polysaccharide loci, suggesting that these RBPs may act as global regulators of polysaccharide metabolism.
34251866	2	24	theme	microbial	213:221	arg1	species					223:229	Gut microbial species	209:229	Gut microbial species that persist in mammalian hosts for long periods of time	209:286	Gut microbial species that persist in mammalian hosts for long periods of time must possess mechanisms for sensing and adapting to nutrient shifts to avoid being outcompeted.
34251866	6	25	theme	other	937:941	arg1	RBPs					968:971	other characterized regulatory RBPs	937:971	other characterized regulatory RBPs	937:971	A purified RBP, RbpB, from Bacteroides thetaiotaomicron binds to single-stranded RNA in vitro with an affinity similar to other characterized regulatory RBPs.
34251866	11	26	from	family	1781:1786	arg1	Bacteroidetes					1825:1837	the Bacteroidetes	1821:1837	the Bacteroidetes	1821:1837	Our data reveal that RbpB is required for optimal expression of BT1871 and other polysaccharide-related genes, suggesting that we have identified an important new family of global regulatory proteins in the Bacteroidetes.
34251866	10	27	from	growth	1574:1579	arg1	raffinose					1593:1601	the RFOs raffinose	1584:1601	the RFOs raffinose	1584:1601	Mutation of BT1871 confirmed that the enzyme it encodes is essential for growth on melibiose and promotes growth on the RFOs raffinose and stachyose.
34251866	10	27	from	growth	1574:1579	arg1	stachyose					1607:1615	stachyose	1607:1615	stachyose	1607:1615	Mutation of BT1871 confirmed that the enzyme it encodes is essential for growth on melibiose and promotes growth on the RFOs raffinose and stachyose.
34251866	14	28	theme	genes	2383:2387	arg1	expression					2344:2353	expression	2344:2353	expression of carbohydrate utilization genes	2344:2387	In this study, we discovered that Bacteroides use a family of RNA-binding proteins as global regulators to coordinate expression of carbohydrate utilization genes.
34251866	15	29	from	gut	2562:2564	arg1	live					2537:2540	live	2537:2540	live	2537:2540	The ability to turn different carbohydrate utilization genes on and off in response to changing nutrient conditions is critical for Bacteroides to live successfully in the gut, and thus the new regulators we have identified may be important for life in the host.
34251866	3	30	from	Bacteroidetes	582:594	arg1	undiscovered					562:573	undiscovered	562:573	undiscovered	562:573	Global regulatory mechanisms mediated by RNA-binding proteins (RBPs) that govern responses to nutrient shifts have been characterized in Proteobacteria and Firmicutes but remain undiscovered in the Bacteroidetes.
34251866	11	31	theme	important	1767:1775	arg1	family					1781:1786	an important new family	1764:1786	an important new family of global regulatory proteins in the Bacteroidetes	1764:1837	Our data reveal that RbpB is required for optimal expression of BT1871 and other polysaccharide-related genes, suggesting that we have identified an important new family of global regulatory proteins in the Bacteroidetes.
34251866	11	32	theme	proteins	1809:1816	arg1	family					1781:1786	an important new family	1764:1786	an important new family of global regulatory proteins in the Bacteroidetes	1764:1837	Our data reveal that RbpB is required for optimal expression of BT1871 and other polysaccharide-related genes, suggesting that we have identified an important new family of global regulatory proteins in the Bacteroidetes.
34251866	0	33	theme	Bacteroides	77:87	arg1	thetaiotaomicron					89:104	Bacteroides thetaiotaomicron	77:104	Bacteroides thetaiotaomicron	77:104	A Novel Family of RNA-Binding Proteins Regulate Polysaccharide Metabolism in Bacteroides thetaiotaomicron.
34251866	13	34	theme	complex	2106:2112	arg1	mechanisms					2125:2134	complex regulatory mechanisms	2106:2134	complex regulatory mechanisms	2106:2134	Bacteroides have many genes responsible for breaking down different dietary carbohydrates, and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available.
34251866	7	35	theme	thetaiotaomicron	977:992	arg1	mutants					994:1000	B. thetaiotaomicron mutants	974:1000	B. thetaiotaomicron mutants lacking RBPs	974:1013	B. thetaiotaomicron mutants lacking RBPs show dramatic shifts in expression of polysaccharide utilization and capsular polysaccharide loci, suggesting that these RBPs may act as global regulators of polysaccharide metabolism.
34251866	10	36	from	growth	1541:1546	arg1	melibiose					1551:1559	melibiose	1551:1559	melibiose	1551:1559	Mutation of BT1871 confirmed that the enzyme it encodes is essential for growth on melibiose and promotes growth on the RFOs raffinose and stachyose.
34251866	11	37	theme	global	1791:1796	arg1	proteins					1809:1816	global regulatory proteins	1791:1816	global regulatory proteins in the Bacteroidetes	1791:1837	Our data reveal that RbpB is required for optimal expression of BT1871 and other polysaccharide-related genes, suggesting that we have identified an important new family of global regulatory proteins in the Bacteroidetes.
34251866	10	38	dep	encodes	1516:1522	arg1	essential					1527:1535	essential	1527:1535	essential	1527:1535	Mutation of BT1871 confirmed that the enzyme it encodes is essential for growth on melibiose and promotes growth on the RFOs raffinose and stachyose.
34251866	10	38	dep	encodes	1516:1522	arg1	promotes					1565:1572	promotes	1565:1572	promotes growth on the RFOs raffinose and stachyose	1565:1615	Mutation of BT1871 confirmed that the enzyme it encodes is essential for growth on melibiose and promotes growth on the RFOs raffinose and stachyose.
34251866	9	39	theme	ΔrbpB	1341:1345	arg1	mutant					1347:1352	The ΔrbpB mutant	1337:1352	The ΔrbpB mutant	1337:1352	The ΔrbpB mutant had reduced expression of BT1871, encoding a predicted RFO-degrading melibiase, compared to the wild-type strain.
34251866	14	40	theme	global	2312:2317	arg1	family					2278:2283	a family	2276:2283	a family of RNA-binding proteins	2276:2307	In this study, we discovered that Bacteroides use a family of RNA-binding proteins as global regulators to coordinate expression of carbohydrate utilization genes.
34251866	14	40	theme	global	2312:2317	arg1	regulators					2319:2328	global regulators	2312:2328	global regulators	2312:2328	In this study, we discovered that Bacteroides use a family of RNA-binding proteins as global regulators to coordinate expression of carbohydrate utilization genes.
34251866	13	41	theme	dietary	2079:2085	arg1	carbohydrates					2087:2099	breaking down different dietary carbohydrates	2055:2099	breaking down different dietary carbohydrates	2055:2099	Bacteroides have many genes responsible for breaking down different dietary carbohydrates, and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available.
34251866	7	42	theme	metabolism	1188:1197	arg1	RBPs					1136:1139	these RBPs	1130:1139	these RBPs	1130:1139	B. thetaiotaomicron mutants lacking RBPs show dramatic shifts in expression of polysaccharide utilization and capsular polysaccharide loci, suggesting that these RBPs may act as global regulators of polysaccharide metabolism.
34251866	7	42	theme	metabolism	1188:1197	arg1	regulators					1159:1168	global regulators	1152:1168	global regulators of polysaccharide metabolism	1152:1197	B. thetaiotaomicron mutants lacking RBPs show dramatic shifts in expression of polysaccharide utilization and capsular polysaccharide loci, suggesting that these RBPs may act as global regulators of polysaccharide metabolism.
34251866	14	43	theme	proteins	2300:2307	arg1	family					2278:2283	a family	2276:2283	a family of RNA-binding proteins	2276:2307	In this study, we discovered that Bacteroides use a family of RNA-binding proteins as global regulators to coordinate expression of carbohydrate utilization genes.
34251866	14	43	theme	proteins	2300:2307	arg1	regulators					2319:2328	global regulators	2312:2328	global regulators	2312:2328	In this study, we discovered that Bacteroides use a family of RNA-binding proteins as global regulators to coordinate expression of carbohydrate utilization genes.
34251866	3	44	theme	RNA-binding	425:435	arg1	RBPs					447:450	RBPs	447:450	RBPs	447:450	Global regulatory mechanisms mediated by RNA-binding proteins (RBPs) that govern responses to nutrient shifts have been characterized in Proteobacteria and Firmicutes but remain undiscovered in the Bacteroidetes.
34251866	3	44	theme	RNA-binding	425:435	arg1	proteins					437:444	RNA-binding proteins	425:444	RNA-binding proteins (RBPs) that govern responses to nutrient shifts	425:492	Global regulatory mechanisms mediated by RNA-binding proteins (RBPs) that govern responses to nutrient shifts have been characterized in Proteobacteria and Firmicutes but remain undiscovered in the Bacteroidetes.
34251866	12	45	theme	genus	1937:1941	arg1	Bacteroides					1943:1953	the genus Bacteroides	1933:1953	the genus Bacteroides	1933:1953	IMPORTANCE The human colon houses hundreds of bacterial species, including many belonging to the genus Bacteroides, that aid in breaking down our food to keep us healthy.
34251866	1	46	theme	Human	107:111	arg1	composition					128:138	Human gut microbiome composition	107:138	Human gut microbiome composition	107:138	Human gut microbiome composition is constantly changing, and diet is a major driver of these changes.
34251866	9	47	contain	had	1354:1356	arg1	mutant					1347:1352	The ΔrbpB mutant	1337:1352	The ΔrbpB mutant	1337:1352	The ΔrbpB mutant had reduced expression of BT1871, encoding a predicted RFO-degrading melibiase, compared to the wild-type strain.
34251866	9	47	contain	had	1354:1356	arg2	expression					1366:1375	reduced expression	1358:1375	reduced expression of BT1871, encoding a predicted RFO-degrading melibiase,	1358:1432	The ΔrbpB mutant had reduced expression of BT1871, encoding a predicted RFO-degrading melibiase, compared to the wild-type strain.
34251866	10	48	dep	enzyme	1506:1511	arg1	it					1513:1514	it	1513:1514	it	1513:1514	Mutation of BT1871 confirmed that the enzyme it encodes is essential for growth on melibiose and promotes growth on the RFOs raffinose and stachyose.
34251866	9	49	theme	BT1871	1380:1385	arg1	expression					1366:1375	reduced expression	1358:1375	reduced expression of BT1871, encoding a predicted RFO-degrading melibiase,	1358:1432	The ΔrbpB mutant had reduced expression of BT1871, encoding a predicted RFO-degrading melibiase, compared to the wild-type strain.
34251866	6	50	theme	single-stranded	880:894	arg1	RNA					896:898	single-stranded RNA	880:898	single-stranded RNA	880:898	A purified RBP, RbpB, from Bacteroides thetaiotaomicron binds to single-stranded RNA in vitro with an affinity similar to other characterized regulatory RBPs.
34251866	1	51	theme	microbiome	117:126	arg1	composition					128:138	Human gut microbiome composition	107:138	Human gut microbiome composition	107:138	Human gut microbiome composition is constantly changing, and diet is a major driver of these changes.
34251866	15	52	from	life	2635:2638	arg1	host					2647:2650	the host	2643:2650	the host	2643:2650	The ability to turn different carbohydrate utilization genes on and off in response to changing nutrient conditions is critical for Bacteroides to live successfully in the gut, and thus the new regulators we have identified may be important for life in the host.
34251866	14	53	theme	carbohydrate	2358:2369	arg1	genes					2383:2387	carbohydrate utilization genes	2358:2387	carbohydrate utilization genes	2358:2387	In this study, we discovered that Bacteroides use a family of RNA-binding proteins as global regulators to coordinate expression of carbohydrate utilization genes.
34251866	0	54	theme	RNA-Binding	18:28	arg1	Proteins					30:37	RNA-Binding Proteins	18:37	RNA-Binding Proteins	18:37	A Novel Family of RNA-Binding Proteins Regulate Polysaccharide Metabolism in Bacteroides thetaiotaomicron.
34251866	5	55	theme	Bacteroides	794:804	arg1	species					806:812	many Bacteroides species	789:812	many Bacteroides species	789:812	Genes encoding these RBPs are highly expressed in many Bacteroides species.
34251866	12	56	theme	human	1855:1859	arg1	colon					1861:1865	The human colon	1851:1865	IMPORTANCE The human colon	1840:1865	IMPORTANCE The human colon houses hundreds of bacterial species, including many belonging to the genus Bacteroides, that aid in breaking down our food to keep us healthy.
34251866	3	57	theme	regulatory	391:400	arg1	mechanisms					402:411	Global regulatory mechanisms	384:411	Global regulatory mechanisms mediated by RNA-binding proteins (RBPs) that govern responses to nutrient shifts	384:492	Global regulatory mechanisms mediated by RNA-binding proteins (RBPs) that govern responses to nutrient shifts have been characterized in Proteobacteria and Firmicutes but remain undiscovered in the Bacteroidetes.
34251866	13	58	theme	responsible	2039:2049	arg1	genes					2033:2037	many genes	2028:2037	many genes responsible for breaking down different dietary carbohydrates	2028:2099	Bacteroides have many genes responsible for breaking down different dietary carbohydrates, and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available.
34251866	7	59	theme	polysaccharide	1173:1186	arg1	metabolism					1188:1197	polysaccharide metabolism	1173:1197	polysaccharide metabolism	1173:1197	B. thetaiotaomicron mutants lacking RBPs show dramatic shifts in expression of polysaccharide utilization and capsular polysaccharide loci, suggesting that these RBPs may act as global regulators of polysaccharide metabolism.
34251866	9	60	theme	predicted	1399:1407	arg1	melibiase					1423:1431	a predicted RFO-degrading melibiase	1397:1431	a predicted RFO-degrading melibiase	1397:1431	The ΔrbpB mutant had reduced expression of BT1871, encoding a predicted RFO-degrading melibiase, compared to the wild-type strain.
34251866	6	61	theme	Bacteroides	842:852	arg1	thetaiotaomicron					854:869	Bacteroides thetaiotaomicron	842:869	Bacteroides thetaiotaomicron	842:869	A purified RBP, RbpB, from Bacteroides thetaiotaomicron binds to single-stranded RNA in vitro with an affinity similar to other characterized regulatory RBPs.
34251866	13	62	theme	breaking	2055:2062	arg1	carbohydrates					2087:2099	breaking down different dietary carbohydrates	2055:2099	breaking down different dietary carbohydrates	2055:2099	Bacteroides have many genes responsible for breaking down different dietary carbohydrates, and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available.
34251866	12	63	theme	bacterial	1886:1894	arg1	species					1896:1902	bacterial species	1886:1902	bacterial species	1886:1902	IMPORTANCE The human colon houses hundreds of bacterial species, including many belonging to the genus Bacteroides, that aid in breaking down our food to keep us healthy.
34251866	7	64	theme	global	1152:1157	arg1	RBPs					1136:1139	these RBPs	1130:1139	these RBPs	1130:1139	B. thetaiotaomicron mutants lacking RBPs show dramatic shifts in expression of polysaccharide utilization and capsular polysaccharide loci, suggesting that these RBPs may act as global regulators of polysaccharide metabolism.
34251866	7	64	theme	global	1152:1157	arg1	regulators					1159:1168	global regulators	1152:1168	global regulators of polysaccharide metabolism	1152:1197	B. thetaiotaomicron mutants lacking RBPs show dramatic shifts in expression of polysaccharide utilization and capsular polysaccharide loci, suggesting that these RBPs may act as global regulators of polysaccharide metabolism.
34251866	13	65	theme	many	2028:2031	arg1	genes					2033:2037	many genes	2028:2037	many genes responsible for breaking down different dietary carbohydrates	2028:2099	Bacteroides have many genes responsible for breaking down different dietary carbohydrates, and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available.
34251866	13	66	contain	have	2023:2026	arg1	Bacteroides					2011:2021	Bacteroides	2011:2021	Bacteroides	2011:2021	Bacteroides have many genes responsible for breaking down different dietary carbohydrates, and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available.
34251866	13	66	contain	have	2023:2026	arg2	genes					2033:2037	many genes	2028:2037	many genes responsible for breaking down different dietary carbohydrates	2028:2099	Bacteroides have many genes responsible for breaking down different dietary carbohydrates, and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available.
34251866	7	67	dep	polysaccharide	1053:1066	arg1	loci					1108:1111	loci	1108:1111	loci	1108:1111	B. thetaiotaomicron mutants lacking RBPs show dramatic shifts in expression of polysaccharide utilization and capsular polysaccharide loci, suggesting that these RBPs may act as global regulators of polysaccharide metabolism.
34251866	7	67	dep	polysaccharide	1053:1066	arg1	utilization					1068:1078	utilization	1068:1078	utilization	1068:1078	B. thetaiotaomicron mutants lacking RBPs show dramatic shifts in expression of polysaccharide utilization and capsular polysaccharide loci, suggesting that these RBPs may act as global regulators of polysaccharide metabolism.
34251866	11	68	theme	optimal	1660:1666	arg1	expression					1668:1677	optimal expression	1660:1677	optimal expression of BT1871 and other polysaccharide-related genes	1660:1726	Our data reveal that RbpB is required for optimal expression of BT1871 and other polysaccharide-related genes, suggesting that we have identified an important new family of global regulatory proteins in the Bacteroidetes.
34251866	2	69	theme	time	283:286	arg1	periods					272:278	long periods	267:278	long periods of time	267:286	Gut microbial species that persist in mammalian hosts for long periods of time must possess mechanisms for sensing and adapting to nutrient shifts to avoid being outcompeted.
34251866	13	70	theme	right	2191:2195	arg1	available					2215:2223	available	2215:2223	available	2215:2223	Bacteroides have many genes responsible for breaking down different dietary carbohydrates, and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available.
34251866	13	70	theme	right	2191:2195	arg1	carbohydrates					2197:2209	the right carbohydrates	2187:2209	the right carbohydrates	2187:2209	Bacteroides have many genes responsible for breaking down different dietary carbohydrates, and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available.
34251866	11	71	theme	polysaccharide-related	1699:1720	arg1	genes					1722:1726	other polysaccharide-related genes	1693:1726	other polysaccharide-related genes	1693:1726	Our data reveal that RbpB is required for optimal expression of BT1871 and other polysaccharide-related genes, suggesting that we have identified an important new family of global regulatory proteins in the Bacteroidetes.
34251866	8	72	theme	thetaiotaomicron	1205:1220	arg1	mutant					1228:1233	A B. thetaiotaomicron ΔrbpB mutant	1200:1233	A B. thetaiotaomicron ΔrbpB mutant	1200:1233	A B. thetaiotaomicron ΔrbpB mutant shows a growth defect on dietary sugars belonging to the raffinose family of oligosaccharides (RFOs).
34251866	11	73	from	Bacteroidetes	1825:1837	arg1	family					1781:1786	an important new family	1764:1786	an important new family of global regulatory proteins in the Bacteroidetes	1764:1837	Our data reveal that RbpB is required for optimal expression of BT1871 and other polysaccharide-related genes, suggesting that we have identified an important new family of global regulatory proteins in the Bacteroidetes.
34251866	15	74	dep	changing	2477:2484	arg1	response					2465:2472	response	2465:2472	response	2465:2472	The ability to turn different carbohydrate utilization genes on and off in response to changing nutrient conditions is critical for Bacteroides to live successfully in the gut, and thus the new regulators we have identified may be important for life in the host.
34251866	4	75	theme	RBPs	635:638	arg1	identification					617:630	the identification	613:630	the identification of RBPs that are broadly distributed across the Bacteroidetes, with many genomes encoding multiple copies	613:736	Here, we report the identification of RBPs that are broadly distributed across the Bacteroidetes, with many genomes encoding multiple copies.
34251866	7	76	theme	polysaccharide	1093:1106	arg1	expression					1039:1048	expression	1039:1048	expression of polysaccharide utilization and capsular polysaccharide loci	1039:1111	B. thetaiotaomicron mutants lacking RBPs show dramatic shifts in expression of polysaccharide utilization and capsular polysaccharide loci, suggesting that these RBPs may act as global regulators of polysaccharide metabolism.
34251866	12	77	theme	breaking	1968:1975	arg1	food					1986:1989	breaking down our food to keep us	1968:2000	breaking down our food to keep us healthy	1968:2008	IMPORTANCE The human colon houses hundreds of bacterial species, including many belonging to the genus Bacteroides, that aid in breaking down our food to keep us healthy.
34251866	15	78	dep	ability	2394:2400	arg1	genes					2445:2449	different carbohydrate utilization genes	2410:2449	The ability to turn different carbohydrate utilization genes	2390:2449	The ability to turn different carbohydrate utilization genes on and off in response to changing nutrient conditions is critical for Bacteroides to live successfully in the gut, and thus the new regulators we have identified may be important for life in the host.
34251866	12	79	theme	healthy	2002:2008	arg1	food					1986:1989	breaking down our food to keep us	1968:2000	breaking down our food to keep us healthy	1968:2008	IMPORTANCE The human colon houses hundreds of bacterial species, including many belonging to the genus Bacteroides, that aid in breaking down our food to keep us healthy.
34251866	8	80	theme	oligosaccharides	1312:1327	arg1	family					1302:1307	the raffinose family	1288:1307	the raffinose family of oligosaccharides (RFOs)	1288:1334	A B. thetaiotaomicron ΔrbpB mutant shows a growth defect on dietary sugars belonging to the raffinose family of oligosaccharides (RFOs).
34251866	15	81	theme	carbohydrate	2420:2431	arg1	genes					2445:2449	different carbohydrate utilization genes	2410:2449	The ability to turn different carbohydrate utilization genes	2390:2449	The ability to turn different carbohydrate utilization genes on and off in response to changing nutrient conditions is critical for Bacteroides to live successfully in the gut, and thus the new regulators we have identified may be important for life in the host.
34251866	8	82	theme	dietary	1260:1266	arg1	sugars					1268:1273	dietary sugars	1260:1273	dietary sugars belonging to the raffinose family of oligosaccharides (RFOs)	1260:1334	A B. thetaiotaomicron ΔrbpB mutant shows a growth defect on dietary sugars belonging to the raffinose family of oligosaccharides (RFOs).
34251866	6	83	theme	characterized	943:955	arg1	RBPs					968:971	other characterized regulatory RBPs	937:971	other characterized regulatory RBPs	937:971	A purified RBP, RbpB, from Bacteroides thetaiotaomicron binds to single-stranded RNA in vitro with an affinity similar to other characterized regulatory RBPs.
34251866	3	84	from	undiscovered	562:573	arg1	Bacteroidetes					582:594	the Bacteroidetes	578:594	the Bacteroidetes	578:594	Global regulatory mechanisms mediated by RNA-binding proteins (RBPs) that govern responses to nutrient shifts have been characterized in Proteobacteria and Firmicutes but remain undiscovered in the Bacteroidetes.
34251866	7	85	theme	polysaccharide	1053:1066	arg1	expression					1039:1048	expression	1039:1048	expression of polysaccharide utilization and capsular polysaccharide loci	1039:1111	B. thetaiotaomicron mutants lacking RBPs show dramatic shifts in expression of polysaccharide utilization and capsular polysaccharide loci, suggesting that these RBPs may act as global regulators of polysaccharide metabolism.
34251866	0	86	theme	Proteins	30:37	arg1	Family					8:13	A Novel Family	0:13	A Novel Family of RNA-Binding Proteins	0:37	A Novel Family of RNA-Binding Proteins Regulate Polysaccharide Metabolism in Bacteroides thetaiotaomicron.
34251866	14	87	theme	utilization	2371:2381	arg1	genes					2383:2387	carbohydrate utilization genes	2358:2387	carbohydrate utilization genes	2358:2387	In this study, we discovered that Bacteroides use a family of RNA-binding proteins as global regulators to coordinate expression of carbohydrate utilization genes.
34251866	13	88	theme	specific	2148:2155	arg1	genes					2157:2161	specific genes	2148:2161	specific genes	2148:2161	Bacteroides have many genes responsible for breaking down different dietary carbohydrates, and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available.
34251866	2	89	theme	mammalian	247:255	arg1	hosts					257:261	mammalian hosts	247:261	mammalian hosts	247:261	Gut microbial species that persist in mammalian hosts for long periods of time must possess mechanisms for sensing and adapting to nutrient shifts to avoid being outcompeted.
34251866	7	90	theme	dramatic	1020:1027	arg1	shifts					1029:1034	dramatic shifts	1020:1034	dramatic shifts	1020:1034	B. thetaiotaomicron mutants lacking RBPs show dramatic shifts in expression of polysaccharide utilization and capsular polysaccharide loci, suggesting that these RBPs may act as global regulators of polysaccharide metabolism.
34251866	11	91	theme	new	1777:1779	arg1	family					1781:1786	an important new family	1764:1786	an important new family of global regulatory proteins in the Bacteroidetes	1764:1837	Our data reveal that RbpB is required for optimal expression of BT1871 and other polysaccharide-related genes, suggesting that we have identified an important new family of global regulatory proteins in the Bacteroidetes.
34251866	15	92	theme	nutrient	2486:2493	arg1	conditions					2495:2504	nutrient conditions	2486:2504	nutrient conditions	2486:2504	The ability to turn different carbohydrate utilization genes on and off in response to changing nutrient conditions is critical for Bacteroides to live successfully in the gut, and thus the new regulators we have identified may be important for life in the host.
34251866	13	93	theme	down	2064:2067	arg1	carbohydrates					2087:2099	breaking down different dietary carbohydrates	2055:2099	breaking down different dietary carbohydrates	2055:2099	Bacteroides have many genes responsible for breaking down different dietary carbohydrates, and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available.
34251866	10	94	theme	BT1871	1480:1485	arg1	Mutation					1468:1475	Mutation	1468:1475	Mutation of BT1871	1468:1485	Mutation of BT1871 confirmed that the enzyme it encodes is essential for growth on melibiose and promotes growth on the RFOs raffinose and stachyose.
34251866	4	95	theme	many	700:703	arg1	genomes					705:711	many genomes	700:711	many genomes encoding multiple copies	700:736	Here, we report the identification of RBPs that are broadly distributed across the Bacteroidetes, with many genomes encoding multiple copies.
34251866	13	96	theme	regulatory	2114:2123	arg1	mechanisms					2125:2134	complex regulatory mechanisms	2106:2134	complex regulatory mechanisms	2106:2134	Bacteroides have many genes responsible for breaking down different dietary carbohydrates, and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available.
34251866	15	97	theme	new	2580:2582	arg1	regulators					2584:2593	the new regulators	2576:2593	the new regulators we have identified may be important for life in the host	2576:2650	The ability to turn different carbohydrate utilization genes on and off in response to changing nutrient conditions is critical for Bacteroides to live successfully in the gut, and thus the new regulators we have identified may be important for life in the host.
34251866	12	98	dep	IMPORTANCE	1840:1849	arg1	colon					1861:1865	The human colon	1851:1865	IMPORTANCE The human colon	1840:1865	IMPORTANCE The human colon houses hundreds of bacterial species, including many belonging to the genus Bacteroides, that aid in breaking down our food to keep us healthy.
34251866	11	99	theme	regulatory	1798:1807	arg1	proteins					1809:1816	global regulatory proteins	1791:1816	global regulatory proteins in the Bacteroidetes	1791:1837	Our data reveal that RbpB is required for optimal expression of BT1871 and other polysaccharide-related genes, suggesting that we have identified an important new family of global regulatory proteins in the Bacteroidetes.
34251866	13	100	theme	different	2069:2077	arg1	carbohydrates					2087:2099	breaking down different dietary carbohydrates	2055:2099	breaking down different dietary carbohydrates	2055:2099	Bacteroides have many genes responsible for breaking down different dietary carbohydrates, and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available.
34251866	7	101	theme	B.	974:975	arg1	mutants					994:1000	B. thetaiotaomicron mutants	974:1000	B. thetaiotaomicron mutants lacking RBPs	974:1013	B. thetaiotaomicron mutants lacking RBPs show dramatic shifts in expression of polysaccharide utilization and capsular polysaccharide loci, suggesting that these RBPs may act as global regulators of polysaccharide metabolism.
34251866	0	102	theme	Novel	2:6	arg1	Family					8:13	A Novel Family	0:13	A Novel Family of RNA-Binding Proteins	0:37	A Novel Family of RNA-Binding Proteins Regulate Polysaccharide Metabolism in Bacteroides thetaiotaomicron.
34251866	9	103	theme	reduced	1358:1364	arg1	expression					1366:1375	reduced expression	1358:1375	reduced expression of BT1871, encoding a predicted RFO-degrading melibiase,	1358:1432	The ΔrbpB mutant had reduced expression of BT1871, encoding a predicted RFO-degrading melibiase, compared to the wild-type strain.
34251866	3	104	theme	Global	384:389	arg1	mechanisms					402:411	Global regulatory mechanisms	384:411	Global regulatory mechanisms mediated by RNA-binding proteins (RBPs) that govern responses to nutrient shifts	384:492	Global regulatory mechanisms mediated by RNA-binding proteins (RBPs) that govern responses to nutrient shifts have been characterized in Proteobacteria and Firmicutes but remain undiscovered in the Bacteroidetes.
34251866	14	105	theme	RNA-binding	2288:2298	arg1	proteins					2300:2307	RNA-binding proteins	2288:2307	RNA-binding proteins	2288:2307	In this study, we discovered that Bacteroides use a family of RNA-binding proteins as global regulators to coordinate expression of carbohydrate utilization genes.
34251866	1	106	theme	gut	113:115	arg1	composition					128:138	Human gut microbiome composition	107:138	Human gut microbiome composition	107:138	Human gut microbiome composition is constantly changing, and diet is a major driver of these changes.
34251866	4	107	with	Bacteroidetes	680:692	arg1	genomes					705:711	many genomes	700:711	many genomes encoding multiple copies	700:736	Here, we report the identification of RBPs that are broadly distributed across the Bacteroidetes, with many genomes encoding multiple copies.
34251866	5	108	theme	many	789:792	arg1	species					806:812	many Bacteroides species	789:812	many Bacteroides species	789:812	Genes encoding these RBPs are highly expressed in many Bacteroides species.
34251866	11	109	theme	genes	1722:1726	arg1	expression					1668:1677	optimal expression	1660:1677	optimal expression of BT1871 and other polysaccharide-related genes	1660:1726	Our data reveal that RbpB is required for optimal expression of BT1871 and other polysaccharide-related genes, suggesting that we have identified an important new family of global regulatory proteins in the Bacteroidetes.
34251866	0	110	theme	Polysaccharide	48:61	arg1	Metabolism					63:72	Polysaccharide Metabolism	48:72	Polysaccharide Metabolism	48:72	A Novel Family of RNA-Binding Proteins Regulate Polysaccharide Metabolism in Bacteroides thetaiotaomicron.
34251866	2	111	contain	possess	293:299	arg2	mechanisms					301:310	mechanisms	301:310	mechanisms for sensing	301:322	Gut microbial species that persist in mammalian hosts for long periods of time must possess mechanisms for sensing and adapting to nutrient shifts to avoid being outcompeted.
34251866	2	111	contain	possess	293:299	arg1	species					223:229	Gut microbial species	209:229	Gut microbial species that persist in mammalian hosts for long periods of time	209:286	Gut microbial species that persist in mammalian hosts for long periods of time must possess mechanisms for sensing and adapting to nutrient shifts to avoid being outcompeted.
34251866	2	112	theme	Gut	209:211	arg1	species					223:229	Gut microbial species	209:229	Gut microbial species that persist in mammalian hosts for long periods of time	209:286	Gut microbial species that persist in mammalian hosts for long periods of time must possess mechanisms for sensing and adapting to nutrient shifts to avoid being outcompeted.
34251866	9	113	theme	RFO-degrading	1409:1421	arg1	melibiase					1423:1431	a predicted RFO-degrading melibiase	1397:1431	a predicted RFO-degrading melibiase	1397:1431	The ΔrbpB mutant had reduced expression of BT1871, encoding a predicted RFO-degrading melibiase, compared to the wild-type strain.
34251866	12	114	theme	species	1896:1902	arg1	hundreds					1874:1881	hundreds	1874:1881	hundreds	1874:1881	IMPORTANCE The human colon houses hundreds of bacterial species, including many belonging to the genus Bacteroides, that aid in breaking down our food to keep us healthy.
34251866	12	114	theme	species	1896:1902	arg1	many					1915:1918	many	1915:1918	many	1915:1918	IMPORTANCE The human colon houses hundreds of bacterial species, including many belonging to the genus Bacteroides, that aid in breaking down our food to keep us healthy.
34251866	3	115	theme	nutrient	478:485	arg1	shifts					487:492	nutrient shifts	478:492	nutrient shifts	478:492	Global regulatory mechanisms mediated by RNA-binding proteins (RBPs) that govern responses to nutrient shifts have been characterized in Proteobacteria and Firmicutes but remain undiscovered in the Bacteroidetes.
34791994	0	0	theme	folic	75:79	arg1	acid					81:84	folic acid	75:84	folic acid	75:84	Investigating the structure of the product of graphene oxide reaction with folic acid and chitosan: density functional theory calculations.
34791994	6	1	from	molecule	809:816	arg1	sides					835:839	both opposite sides	821:839	both opposite sides	821:839	In GO-CS, DFT calculation show that two Chitosan connected to the GO molecule on both opposite sides, so that two Chitosan have maximum distance from each other.
34791994	4	2	theme	gas-phase	532:540	arg1	properties					542:551	gas-phase properties	532:551	gas-phase properties	532:551	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	3	dep	oxide	597:601	arg1	GO					604:605	GO	604:605	GO	604:605	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	9	4	theme	bond	1175:1178	arg1	orbital					1180:1186	natural bond orbital	1167:1186	molecules natural bond orbital analyses.Communicated by Ramaswamy H. Sarma	1157:1230	Furthermore, the hydrogen bonds were studied by atom in molecules natural bond orbital analyses.Communicated by Ramaswamy H. Sarma.
34791994	2	5	used	used	330:333	arg2	composite					216:224	composite	216:224	composite	216:224	And the composite prepared from graphene oxide/chitosan, due to its favorable physical and chemical properties, have been used as a drug delivery system.
34791994	2	5	used	used	330:333	arg2	system					354:359	a drug delivery system	338:359	a drug delivery system	338:359	And the composite prepared from graphene oxide/chitosan, due to its favorable physical and chemical properties, have been used as a drug delivery system.
34791994	6	6	contain	have	863:866	arg1	Chitosan					780:787	Chitosan	780:787	Chitosan	780:787	In GO-CS, DFT calculation show that two Chitosan connected to the GO molecule on both opposite sides, so that two Chitosan have maximum distance from each other.
34791994	6	6	contain	have	863:866	arg2	distance					876:883	maximum distance	868:883	maximum distance from each other	868:899	In GO-CS, DFT calculation show that two Chitosan connected to the GO molecule on both opposite sides, so that two Chitosan have maximum distance from each other.
34791994	0	7	with	reaction	61:68	arg1	chitosan					90:97	chitosan	90:97	chitosan	90:97	Investigating the structure of the product of graphene oxide reaction with folic acid and chitosan: density functional theory calculations.
34791994	0	7	with	reaction	61:68	arg1	acid					81:84	folic acid	75:84	folic acid	75:84	Investigating the structure of the product of graphene oxide reaction with folic acid and chitosan: density functional theory calculations.
34791994	4	8	theme	GO-CS	641:645	arg1	properties					542:551	gas-phase properties	532:551	gas-phase properties	532:551	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	8	theme	GO-CS	641:645	arg1	optimizations					490:502	The geometry optimizations	477:502	The geometry optimizations	477:502	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	8	theme	GO-CS	641:645	arg1	structures					516:525	electronic structures	505:525	electronic structures	505:525	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	8	9	theme	bonds	1028:1032	arg1	interaction					1004:1014	The interaction	1000:1014	The interaction of hydrogen bonds in the most stable pair formers between molecules	1000:1082	The interaction of hydrogen bonds in the most stable pair formers between molecules were determined.
34791994	2	10	theme	due	265:267	arg1	oxide/chitosan					249:262	graphene oxide/chitosan	240:262	graphene oxide/chitosan	240:262	And the composite prepared from graphene oxide/chitosan, due to its favorable physical and chemical properties, have been used as a drug delivery system.
34791994	3	11	theme	Folic	395:399	arg1	acid					401:404	Folic acid	395:404	Folic acid	395:404	In this study, the adsorption of Folic acid on the carrier was investigated using density functional theory (DFT).
34791994	8	12	theme	hydrogen	1019:1026	arg1	bonds					1028:1032	hydrogen bonds	1019:1032	hydrogen bonds	1019:1032	The interaction of hydrogen bonds in the most stable pair formers between molecules were determined.
34791994	9	13	theme	natural	1167:1173	arg1	orbital					1180:1186	natural bond orbital	1167:1186	molecules natural bond orbital analyses.Communicated by Ramaswamy H. Sarma	1157:1230	Furthermore, the hydrogen bonds were studied by atom in molecules natural bond orbital analyses.Communicated by Ramaswamy H. Sarma.
34791994	6	14	from	other	895:899	arg1	distance					876:883	maximum distance	868:883	maximum distance from each other	868:899	In GO-CS, DFT calculation show that two Chitosan connected to the GO molecule on both opposite sides, so that two Chitosan have maximum distance from each other.
34791994	4	15	theme	geometry	481:488	arg1	optimizations					490:502	The geometry optimizations	477:502	The geometry optimizations	477:502	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	3	16	theme	acid	401:404	arg1	adsorption					381:390	the adsorption	377:390	the adsorption of Folic acid on the carrier	377:419	In this study, the adsorption of Folic acid on the carrier was investigated using density functional theory (DFT).
34791994	6	17	theme	DFT	750:752	arg1	calculation					754:764	DFT calculation	750:764	DFT calculation	750:764	In GO-CS, DFT calculation show that two Chitosan connected to the GO molecule on both opposite sides, so that two Chitosan have maximum distance from each other.
34791994	2	18	theme	chemical	299:306	arg1	properties					308:317	its favorable physical and chemical properties	272:317	its favorable physical and chemical properties	272:317	And the composite prepared from graphene oxide/chitosan, due to its favorable physical and chemical properties, have been used as a drug delivery system.
34791994	5	19	theme	studied	693:699	arg1	molecules					701:709	The studied molecules	689:709	The studied molecules	689:709	The studied molecules are based on graphene oxide.
34791994	4	20	theme	electronic	505:514	arg1	structures					516:525	electronic structures	505:525	electronic structures	505:525	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	7	21	theme	FA	939:940	arg1	structure					926:934	the electronic structure	911:934	the electronic structure of FA	911:940	Finally, the electronic structure of FA was obtained with this molecule calculated and discussed.
34791994	9	22	dep	molecules	1157:1165	arg1	orbital					1180:1186	natural bond orbital	1167:1186	molecules natural bond orbital analyses.Communicated by Ramaswamy H. Sarma	1157:1230	Furthermore, the hydrogen bonds were studied by atom in molecules natural bond orbital analyses.Communicated by Ramaswamy H. Sarma.
34791994	9	23	from	atom	1149:1152	arg1	molecules					1157:1165	molecules natural bond orbital	1157:1186	molecules natural bond orbital analyses.Communicated by Ramaswamy H. Sarma	1157:1230	Furthermore, the hydrogen bonds were studied by atom in molecules natural bond orbital analyses.Communicated by Ramaswamy H. Sarma.
34791994	2	24	theme	delivery	345:352	arg1	composite					216:224	composite	216:224	composite	216:224	And the composite prepared from graphene oxide/chitosan, due to its favorable physical and chemical properties, have been used as a drug delivery system.
34791994	2	24	theme	delivery	345:352	arg1	system					354:359	a drug delivery system	338:359	a drug delivery system	338:359	And the composite prepared from graphene oxide/chitosan, due to its favorable physical and chemical properties, have been used as a drug delivery system.
34791994	5	25	theme	graphene	724:731	arg1	oxide					733:737	graphene oxide	724:737	graphene oxide	724:737	The studied molecules are based on graphene oxide.
34791994	0	26	theme	functional	108:117	arg1	calculations					126:137	density functional theory calculations	100:137	density functional theory calculations	100:137	Investigating the structure of the product of graphene oxide reaction with folic acid and chitosan: density functional theory calculations.
34791994	8	27	theme	stable	1046:1051	arg1	formers					1058:1064	the most stable pair formers	1037:1064	the most stable pair formers between molecules	1037:1082	The interaction of hydrogen bonds in the most stable pair formers between molecules were determined.
34791994	2	28	theme	physical	286:293	arg1	properties					308:317	its favorable physical and chemical properties	272:317	its favorable physical and chemical properties	272:317	And the composite prepared from graphene oxide/chitosan, due to its favorable physical and chemical properties, have been used as a drug delivery system.
34791994	6	29	theme	opposite	826:833	arg1	sides					835:839	both opposite sides	821:839	both opposite sides	821:839	In GO-CS, DFT calculation show that two Chitosan connected to the GO molecule on both opposite sides, so that two Chitosan have maximum distance from each other.
34791994	0	30	theme	density	100:106	arg1	calculations					126:137	density functional theory calculations	100:137	density functional theory calculations	100:137	Investigating the structure of the product of graphene oxide reaction with folic acid and chitosan: density functional theory calculations.
34791994	2	31	theme	favorable	276:284	arg1	properties					308:317	its favorable physical and chemical properties	272:317	its favorable physical and chemical properties	272:317	And the composite prepared from graphene oxide/chitosan, due to its favorable physical and chemical properties, have been used as a drug delivery system.
34791994	4	32	theme	chitosan	609:616	arg1	properties					542:551	gas-phase properties	532:551	gas-phase properties	532:551	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	32	theme	chitosan	609:616	arg1	optimizations					490:502	The geometry optimizations	477:502	The geometry optimizations	477:502	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	32	theme	chitosan	609:616	arg1	structures					516:525	electronic structures	505:525	electronic structures	505:525	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	0	33	theme	product	35:41	arg1	structure					18:26	the structure	14:26	the structure of the product of graphene oxide reaction with folic acid and chitosan	14:97	Investigating the structure of the product of graphene oxide reaction with folic acid and chitosan: density functional theory calculations.
34791994	4	34	theme	graphene	588:595	arg1	oxide					597:601	graphene oxide	588:601	graphene oxide (GO)	588:606	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	1	35	theme	graphene	192:199	arg1	oxide					201:205	graphene oxide	192:205	graphene oxide	192:205	Chitosan biopolymer was used to modify the level of graphene oxide.
34791994	8	36	theme	pair	1053:1056	arg1	formers					1058:1064	the most stable pair formers	1037:1064	the most stable pair formers between molecules	1037:1082	The interaction of hydrogen bonds in the most stable pair formers between molecules were determined.
34791994	0	37	theme	theory	119:124	arg1	calculations					126:137	density functional theory calculations	100:137	density functional theory calculations	100:137	Investigating the structure of the product of graphene oxide reaction with folic acid and chitosan: density functional theory calculations.
34791994	7	38	dep	molecule	965:972	arg1	discussed					989:997	discussed	989:997	discussed	989:997	Finally, the electronic structure of FA was obtained with this molecule calculated and discussed.
34791994	7	38	dep	molecule	965:972	arg1	calculated					974:983	calculated	974:983	calculated	974:983	Finally, the electronic structure of FA was obtained with this molecule calculated and discussed.
34791994	1	39	theme	oxide	201:205	arg1	level					183:187	the level	179:187	the level of graphene oxide	179:205	Chitosan biopolymer was used to modify the level of graphene oxide.
34791994	0	40	theme	graphene	46:53	arg1	reaction					61:68	graphene oxide reaction	46:68	graphene oxide reaction with folic acid and chitosan	46:97	Investigating the structure of the product of graphene oxide reaction with folic acid and chitosan: density functional theory calculations.
34791994	3	41	theme	density	444:450	arg1	DFT					471:473	DFT	471:473	DFT	471:473	In this study, the adsorption of Folic acid on the carrier was investigated using density functional theory (DFT).
34791994	3	41	theme	density	444:450	arg1	theory					463:468	density functional theory	444:468	density functional theory (DFT)	444:474	In this study, the adsorption of Folic acid on the carrier was investigated using density functional theory (DFT).
34791994	6	42	theme	GO	806:807	arg1	molecule					809:816	the GO molecule	802:816	the GO molecule	802:816	In GO-CS, DFT calculation show that two Chitosan connected to the GO molecule on both opposite sides, so that two Chitosan have maximum distance from each other.
34791994	7	43	theme	electronic	915:924	arg1	structure					926:934	the electronic structure	911:934	the electronic structure of FA	911:940	Finally, the electronic structure of FA was obtained with this molecule calculated and discussed.
34791994	3	44	theme	functional	452:461	arg1	DFT					471:473	DFT	471:473	DFT	471:473	In this study, the adsorption of Folic acid on the carrier was investigated using density functional theory (DFT).
34791994	3	44	theme	functional	452:461	arg1	theory					463:468	density functional theory	444:468	density functional theory (DFT)	444:474	In this study, the adsorption of Folic acid on the carrier was investigated using density functional theory (DFT).
34791994	0	45	dep	Investigating	0:12	arg1	calculations					126:137	density functional theory calculations	100:137	density functional theory calculations	100:137	Investigating the structure of the product of graphene oxide reaction with folic acid and chitosan: density functional theory calculations.
34791994	4	46	theme	acid	630:633	arg1	properties					542:551	gas-phase properties	532:551	gas-phase properties	532:551	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	46	theme	acid	630:633	arg1	optimizations					490:502	The geometry optimizations	477:502	The geometry optimizations	477:502	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	46	theme	acid	630:633	arg1	structures					516:525	electronic structures	505:525	electronic structures	505:525	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	47	theme	applicable	563:572	arg1	G					584:584	G	584:584	G	584:584	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	47	theme	applicable	563:572	arg1	graphene					574:581	widely applicable graphene	556:581	widely applicable graphene (G)	556:585	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	48	theme	GO-CS-FA	651:658	arg1	properties					542:551	gas-phase properties	532:551	gas-phase properties	532:551	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	48	theme	GO-CS-FA	651:658	arg1	optimizations					490:502	The geometry optimizations	477:502	The geometry optimizations	477:502	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	48	theme	GO-CS-FA	651:658	arg1	structures					516:525	electronic structures	505:525	electronic structures	505:525	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	9	49	theme	hydrogen	1118:1125	arg1	bonds					1127:1131	the hydrogen bonds	1114:1131	the hydrogen bonds	1114:1131	Furthermore, the hydrogen bonds were studied by atom in molecules natural bond orbital analyses.Communicated by Ramaswamy H. Sarma.
34791994	2	50	theme	graphene	240:247	arg1	oxide/chitosan					249:262	graphene oxide/chitosan	240:262	graphene oxide/chitosan	240:262	And the composite prepared from graphene oxide/chitosan, due to its favorable physical and chemical properties, have been used as a drug delivery system.
34791994	3	51	from	adsorption	381:390	arg1	carrier					413:419	the carrier	409:419	the carrier	409:419	In this study, the adsorption of Folic acid on the carrier was investigated using density functional theory (DFT).
34791994	4	52	theme	folic	624:628	arg1	FA					636:637	FA	636:637	FA	636:637	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	52	theme	folic	624:628	arg1	acid					630:633	folic acid	624:633	folic acid (FA)	624:638	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	0	53	theme	reaction	61:68	arg1	product					35:41	the product	31:41	the product of graphene oxide reaction with folic acid and chitosan	31:97	Investigating the structure of the product of graphene oxide reaction with folic acid and chitosan: density functional theory calculations.
34791994	8	54	from	interaction	1004:1014	arg1	formers					1058:1064	the most stable pair formers	1037:1064	the most stable pair formers between molecules	1037:1082	The interaction of hydrogen bonds in the most stable pair formers between molecules were determined.
34791994	2	55	theme	drug	340:343	arg1	composite					216:224	composite	216:224	composite	216:224	And the composite prepared from graphene oxide/chitosan, due to its favorable physical and chemical properties, have been used as a drug delivery system.
34791994	2	55	theme	drug	340:343	arg1	system					354:359	a drug delivery system	338:359	a drug delivery system	338:359	And the composite prepared from graphene oxide/chitosan, due to its favorable physical and chemical properties, have been used as a drug delivery system.
34791994	4	56	theme	oxide	597:601	arg1	properties					542:551	gas-phase properties	532:551	gas-phase properties	532:551	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	56	theme	oxide	597:601	arg1	optimizations					490:502	The geometry optimizations	477:502	The geometry optimizations	477:502	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	56	theme	oxide	597:601	arg1	structures					516:525	electronic structures	505:525	electronic structures	505:525	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	6	57	theme	maximum	868:874	arg1	distance					876:883	maximum distance	868:883	maximum distance from each other	868:899	In GO-CS, DFT calculation show that two Chitosan connected to the GO molecule on both opposite sides, so that two Chitosan have maximum distance from each other.
34791994	0	58	theme	oxide	55:59	arg1	reaction					61:68	graphene oxide reaction	46:68	graphene oxide reaction with folic acid and chitosan	46:97	Investigating the structure of the product of graphene oxide reaction with folic acid and chitosan: density functional theory calculations.
34791994	1	59	used	used	164:167	arg2	biopolymer					149:158	Chitosan biopolymer	140:158	Chitosan biopolymer	140:158	Chitosan biopolymer was used to modify the level of graphene oxide.
34791994	1	60	theme	Chitosan	140:147	arg1	biopolymer					149:158	Chitosan biopolymer	140:158	Chitosan biopolymer	140:158	Chitosan biopolymer was used to modify the level of graphene oxide.
34791994	4	61	theme	graphene	574:581	arg1	properties					542:551	gas-phase properties	532:551	gas-phase properties	532:551	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	61	theme	graphene	574:581	arg1	optimizations					490:502	The geometry optimizations	477:502	The geometry optimizations	477:502	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
34791994	4	61	theme	graphene	574:581	arg1	structures					516:525	electronic structures	505:525	electronic structures	505:525	The geometry optimizations, electronic structures, and gas-phase properties of widely applicable graphene (G), graphene oxide (GO), chitosan (CS), folic acid (FA), GO-CS and GO-CS-FA were investigated using DFT.
33174770	7	0	used	used	1142:1145	arg2	Agarose					1130:1136	Agarose	1130:1136	Agarose	1130:1136	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	7	0	used	used	1142:1145	arg2	network					1158:1164	a first network	1150:1164	a first network	1150:1164	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	12	1	theme	non-inflammatory	2063:2078	arg1	materials					2080:2088	non-inflammatory materials	2063:2088	non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material	2063:2221	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	5	2	theme	novel	665:669	arg1	composite					725:733	A novel high strength interpenetrating network (IPN) hydrogel composite	663:733	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	663:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	3	3	theme	OOKP	541:544	arg1	surgery					547:553	osteo-odonto-keratoprosthesis (OOKP) surgery	510:553	osteo-odonto-keratoprosthesis (OOKP) surgery	510:553	Tissue engineering approaches to bone replacement may offer suitable alternatives in osteo-odonto-keratoprosthesis (OOKP) surgery.
33174770	5	4	theme	strength	676:683	arg1	composite					725:733	A novel high strength interpenetrating network (IPN) hydrogel composite	663:733	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	663:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	11	5	theme	IL-6	1884:1887	arg1	production					1848:1857	significant production	1836:1857	significant production of inflammatory cytokine IL-6	1836:1887	The material did not induce significant production of inflammatory cytokine IL-6 in comparison to a positive control (p < 0.05) indicating non-inflammatory potential.
33174770	1	6	theme	many	274:277	arg1	years					279:283	many years	274:283	many years	274:283	Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years.
33174770	12	7	theme	OOKP	2122:2125	arg1	skirt					2127:2131	OOKP skirt	2122:2131	OOKP skirt	2122:2131	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	12	8	theme	dental	2169:2174	arg1	biomimicry					2185:2194	dental laminate biomimicry	2169:2194	dental laminate biomimicry in the OOKP skirt material	2169:2221	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	10	9	theme	1 week	1737:1742	arg1	post-encapsulation					1744:1761	1 week post-encapsulation	1737:1761	1 week post-encapsulation	1737:1761	The cells endured the encapsulation process into the IPN and remained viable at 1 week post-encapsulation in the presence of nHAp coated microspheres.
33174770	12	10	theme	composite	1997:2005	arg1	supportive					2051:2060	supportive	2051:2060	supportive	2051:2060	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	12	10	theme	composite	1997:2005	arg1	hydrogels					2011:2019	The nHAp encapsulated composite IPN hydrogels	1975:2019	The nHAp encapsulated composite IPN hydrogels	1975:2019	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	2	11	theme	many	305:308	arg1	intricacies					310:320	many intricacies	305:320	many intricacies associated with the use of autologous dental laminate material, surgical complexity and skirt erosion	305:422	However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexity and skirt erosion.
33174770	6	12	theme	nHAp	977:980	arg1	microspheres					994:1005	nHAp coated PLGA microspheres	977:1005	nHAp coated PLGA microspheres	977:1005	The incorporation of nHAp coated PLGA microspheres into the hybrid IPN network provide a micro-environment similar to that of skeletal tissues and improve cellular response.
33174770	4	13	theme	OOKP	651:654	arg1	skirt					656:660	the OOKP skirt	647:660	the OOKP skirt	647:660	In this study, a hydrogel polymer composite was investigated as a synthetic substitute for the OOKP skirt.
33174770	5	14	theme	hydrogel	716:723	arg1	composite					725:733	A novel high strength interpenetrating network (IPN) hydrogel composite	663:733	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	663:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	11	15	theme	positive	1908:1915	arg1	control					1917:1923	a positive control	1906:1923	a positive control (p < 0.05)	1906:1934	The material did not induce significant production of inflammatory cytokine IL-6 in comparison to a positive control (p < 0.05) indicating non-inflammatory potential.
33174770	11	15	theme	positive	1908:1915	arg1	p < 0.05					1926:1933	p < 0.05	1926:1933	p < 0.05	1926:1933	The material did not induce significant production of inflammatory cytokine IL-6 in comparison to a positive control (p < 0.05) indicating non-inflammatory potential.
33174770	8	16	theme	coated	1432:1437	arg1	microspheres					1444:1455	nHAp coated PLGA microspheres	1427:1455	nHAp coated PLGA microspheres	1427:1455	An increased concentration of either agarose or PEG-DA and incorporation of nHAp coated PLGA microspheres led to an increase in the elastic modulus.
33174770	2	17	theme	material	376:383	arg1	complexity					395:404	surgical complexity	386:404	surgical complexity	386:404	However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexity and skirt erosion.
33174770	2	17	theme	material	376:383	arg1	use					342:344	the use	338:344	the use of autologous dental laminate material	338:383	However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexity and skirt erosion.
33174770	2	17	theme	material	376:383	arg1	erosion					416:422	skirt erosion	410:422	skirt erosion	410:422	However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexity and skirt erosion.
33174770	12	18	theme	nHAp	1979:1982	arg1	supportive					2051:2060	supportive	2051:2060	supportive	2051:2060	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	12	18	theme	nHAp	1979:1982	arg1	hydrogels					2011:2019	The nHAp encapsulated composite IPN hydrogels	1975:2019	The nHAp encapsulated composite IPN hydrogels	1975:2019	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	8	19	theme	microspheres	1444:1455	arg1	incorporation					1410:1422	incorporation	1410:1422	incorporation of nHAp coated PLGA microspheres	1410:1455	An increased concentration of either agarose or PEG-DA and incorporation of nHAp coated PLGA microspheres led to an increase in the elastic modulus.
33174770	8	19	theme	microspheres	1444:1455	arg1	concentration					1364:1376	An increased concentration	1351:1376	An increased concentration of either agarose or PEG-DA	1351:1404	An increased concentration of either agarose or PEG-DA and incorporation of nHAp coated PLGA microspheres led to an increase in the elastic modulus.
33174770	9	20	dep	adhesion	1544:1551	arg1	the					1540:1542	the	1540:1542	the	1540:1542	The IPN hydrogel combinations supported the adhesion and proliferation of both fibroblast and ocular human keratocyte cell types during in in-vitro testing.
33174770	5	21	theme	network	702:708	arg1	composite					725:733	A novel high strength interpenetrating network (IPN) hydrogel composite	663:733	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	663:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	10	22	theme	microspheres	1794:1805	arg1	presence					1770:1777	the presence	1766:1777	the presence of nHAp coated microspheres	1766:1805	The cells endured the encapsulation process into the IPN and remained viable at 1 week post-encapsulation in the presence of nHAp coated microspheres.
33174770	5	23	theme	diacrylate	927:936	arg1	polymers					946:953	diacrylate (PEGDA) polymers	927:953	diacrylate (PEGDA) polymers	927:953	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	11	24	dep	control	1917:1923	arg1	comparison					1892:1901	comparison	1892:1901	comparison	1892:1901	The material did not induce significant production of inflammatory cytokine IL-6 in comparison to a positive control (p < 0.05) indicating non-inflammatory potential.
33174770	5	25	theme	IPN	711:713	arg1	composite					725:733	A novel high strength interpenetrating network (IPN) hydrogel composite	663:733	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	663:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	4	26	dep	synthetic	622:630	arg1	substitute					632:641	substitute	632:641	substitute for the OOKP skirt	632:660	In this study, a hydrogel polymer composite was investigated as a synthetic substitute for the OOKP skirt.
33174770	5	27	theme	PEGDA	939:943	arg1	polymers					946:953	diacrylate (PEGDA) polymers	927:953	diacrylate (PEGDA) polymers	927:953	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	5	28	theme	coated	779:784	arg1	microspheres					822:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	9	29	theme	IPN	1504:1506	arg1	combinations					1517:1528	The IPN hydrogel combinations	1500:1528	The IPN hydrogel combinations	1500:1528	The IPN hydrogel combinations supported the adhesion and proliferation of both fibroblast and ocular human keratocyte cell types during in in-vitro testing.
33174770	6	30	theme	hybrid	1016:1021	arg1	network					1027:1033	the hybrid IPN network	1012:1033	the hybrid IPN network	1012:1033	The incorporation of nHAp coated PLGA microspheres into the hybrid IPN network provide a micro-environment similar to that of skeletal tissues and improve cellular response.
33174770	12	31	from	biomimicry	2185:2194	arg1	material					2214:2221	the OOKP skirt material	2199:2221	the OOKP skirt material	2199:2221	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	1	32	theme	methyl	198:203	arg1	poly					193:196	a central poly	183:196	a central poly(methyl methacrylate) (PMMA) optic	183:230	Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years.
33174770	1	32	theme	methyl	198:203	arg1	methacrylate					205:216	methyl methacrylate	198:216	methyl methacrylate	198:216	Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years.
33174770	5	33	theme	hydroxyapatite	757:770	arg1	microspheres					822:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	7	34	used	used	1233:1236	arg2	6000 Da					1220:1226	6000 Da	1220:1226	6000 Da	1220:1226	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	7	34	used	used	1233:1236	arg2	PEGDA					1213:1217	PEGDA	1213:1217	PEGDA (6000 Da)	1213:1227	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	7	34	used	used	1233:1236	arg2	network					1250:1256	a second network	1241:1256	a second network with varying concentrations (20 and 40 wt %)	1241:1301	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	6	35	theme	PLGA	989:992	arg1	microspheres					994:1005	nHAp coated PLGA microspheres	977:1005	nHAp coated PLGA microspheres	977:1005	The incorporation of nHAp coated PLGA microspheres into the hybrid IPN network provide a micro-environment similar to that of skeletal tissues and improve cellular response.
33174770	5	36	theme	nHAp	773:776	arg1	microspheres					822:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	5	37	theme	lactic-co-glycolic	792:809	arg1	poly					786:789	poly	786:789	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	5	37	theme	lactic-co-glycolic	792:809	arg1	acid					811:814	lactic-co-glycolic acid	792:814	lactic-co-glycolic acid	792:814	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	1	38	theme	dental	129:134	arg1	material					145:152	dental laminate material	129:152	dental laminate material	129:152	Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years.
33174770	1	38	theme	dental	129:134	arg1	skirt					170:174	an anchoring skirt	157:174	an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic	157:230	Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years.
33174770	7	39	theme	strong	1316:1321	arg1	scaffold					1341:1348	a strong and biocompatible scaffold	1314:1348	a strong and biocompatible scaffold	1314:1348	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	12	40	theme	IPN	2007:2009	arg1	supportive					2051:2060	supportive	2051:2060	supportive	2051:2060	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	12	40	theme	IPN	2007:2009	arg1	hydrogels					2011:2019	The nHAp encapsulated composite IPN hydrogels	1975:2019	The nHAp encapsulated composite IPN hydrogels	1975:2019	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	8	41	theme	increased	1354:1362	arg1	concentration					1364:1376	An increased concentration	1351:1376	An increased concentration of either agarose or PEG-DA	1351:1404	An increased concentration of either agarose or PEG-DA and incorporation of nHAp coated PLGA microspheres led to an increase in the elastic modulus.
33174770	3	42	theme	Tissue	425:430	arg1	approaches					444:453	Tissue engineering approaches	425:453	Tissue engineering approaches to bone replacement	425:473	Tissue engineering approaches to bone replacement may offer suitable alternatives in osteo-odonto-keratoprosthesis (OOKP) surgery.
33174770	0	43	theme	Biomimetic	0:9	arg1	composites					21:30	Biomimetic bone-like composites	0:30	Biomimetic bone-like composites as osteo-odonto-keratoprosthesis	0:63	Biomimetic bone-like composites as osteo-odonto-keratoprosthesis skirt substitutes.
33174770	5	44	dep	agarose	893:899	arg1	polymers					946:953	diacrylate (PEGDA) polymers	927:953	diacrylate (PEGDA) polymers	927:953	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	10	45	theme	encapsulation	1679:1691	arg1	process					1693:1699	the encapsulation process	1675:1699	the encapsulation process	1675:1699	The cells endured the encapsulation process into the IPN and remained viable at 1 week post-encapsulation in the presence of nHAp coated microspheres.
33174770	9	46	theme	fibroblast	1579:1588	arg1	adhesion					1544:1551	adhesion	1544:1551	adhesion	1544:1551	The IPN hydrogel combinations supported the adhesion and proliferation of both fibroblast and ocular human keratocyte cell types during in in-vitro testing.
33174770	9	46	theme	fibroblast	1579:1588	arg1	proliferation					1557:1569	proliferation	1557:1569	proliferation	1557:1569	The IPN hydrogel combinations supported the adhesion and proliferation of both fibroblast and ocular human keratocyte cell types during in in-vitro testing.
33174770	6	47	theme	similar	1063:1069	arg1	micro-environment					1045:1061	a micro-environment	1043:1061	a micro-environment similar to that of skeletal tissues	1043:1097	The incorporation of nHAp coated PLGA microspheres into the hybrid IPN network provide a micro-environment similar to that of skeletal tissues and improve cellular response.
33174770	4	48	theme	hydrogel	573:580	arg1	synthetic					622:630	synthetic	622:630	synthetic	622:630	In this study, a hydrogel polymer composite was investigated as a synthetic substitute for the OOKP skirt.
33174770	4	48	theme	hydrogel	573:580	arg1	composite					590:598	a hydrogel polymer composite	571:598	a hydrogel polymer composite	571:598	In this study, a hydrogel polymer composite was investigated as a synthetic substitute for the OOKP skirt.
33174770	2	49	theme	skirt	410:414	arg1	erosion					416:422	skirt erosion	410:422	skirt erosion	410:422	However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexity and skirt erosion.
33174770	8	50	theme	agarose	1388:1394	arg1	incorporation					1410:1422	incorporation	1410:1422	incorporation of nHAp coated PLGA microspheres	1410:1455	An increased concentration of either agarose or PEG-DA and incorporation of nHAp coated PLGA microspheres led to an increase in the elastic modulus.
33174770	8	50	theme	agarose	1388:1394	arg1	concentration					1364:1376	An increased concentration	1351:1376	An increased concentration of either agarose or PEG-DA	1351:1404	An increased concentration of either agarose or PEG-DA and incorporation of nHAp coated PLGA microspheres led to an increase in the elastic modulus.
33174770	3	51	theme	bone	458:461	arg1	replacement					463:473	bone replacement	458:473	bone replacement	458:473	Tissue engineering approaches to bone replacement may offer suitable alternatives in osteo-odonto-keratoprosthesis (OOKP) surgery.
33174770	9	52	theme	ocular	1594:1599	arg1	types					1623:1627	both fibroblast and ocular human keratocyte cell types	1574:1627	types	1623:1627	The IPN hydrogel combinations supported the adhesion and proliferation of both fibroblast and ocular human keratocyte cell types during in in-vitro testing.
33174770	8	53	theme	PEG-DA	1399:1404	arg1	incorporation					1410:1422	incorporation	1410:1422	incorporation of nHAp coated PLGA microspheres	1410:1455	An increased concentration of either agarose or PEG-DA and incorporation of nHAp coated PLGA microspheres led to an increase in the elastic modulus.
33174770	8	53	theme	PEG-DA	1399:1404	arg1	concentration					1364:1376	An increased concentration	1351:1376	An increased concentration of either agarose or PEG-DA	1351:1404	An increased concentration of either agarose or PEG-DA and incorporation of nHAp coated PLGA microspheres led to an increase in the elastic modulus.
33174770	11	54	theme	inflammatory	1862:1873	arg1	IL-6					1884:1887	inflammatory cytokine IL-6	1862:1887	inflammatory cytokine IL-6	1862:1887	The material did not induce significant production of inflammatory cytokine IL-6 in comparison to a positive control (p < 0.05) indicating non-inflammatory potential.
33174770	5	55	theme	PLGA	817:820	arg1	microspheres					822:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	9	56	theme	keratocyte	1607:1616	arg1	types					1623:1627	both fibroblast and ocular human keratocyte cell types	1574:1627	types	1623:1627	The IPN hydrogel combinations supported the adhesion and proliferation of both fibroblast and ocular human keratocyte cell types during in in-vitro testing.
33174770	3	57	theme	suitable	485:492	arg1	alternatives					494:505	suitable alternatives	485:505	suitable alternatives	485:505	Tissue engineering approaches to bone replacement may offer suitable alternatives in osteo-odonto-keratoprosthesis (OOKP) surgery.
33174770	1	58	used	used	243:246	arg2	Osteo-odonto-keratoprostheses					84:112	Osteo-odonto-keratoprostheses	84:112	Osteo-odonto-keratoprostheses	84:112	Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years.
33174770	9	59	theme	types	1623:1627	arg1	adhesion					1544:1551	adhesion	1544:1551	adhesion	1544:1551	The IPN hydrogel combinations supported the adhesion and proliferation of both fibroblast and ocular human keratocyte cell types during in in-vitro testing.
33174770	9	59	theme	types	1623:1627	arg1	proliferation					1557:1569	proliferation	1557:1569	proliferation	1557:1569	The IPN hydrogel combinations supported the adhesion and proliferation of both fibroblast and ocular human keratocyte cell types during in in-vitro testing.
33174770	1	60	theme	poly	193:196	arg1	optic					226:230	a central poly(methyl methacrylate) (PMMA) optic	183:230	a central poly(methyl methacrylate) (PMMA) optic	183:230	Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years.
33174770	8	61	theme	nHAp	1427:1430	arg1	microspheres					1444:1455	nHAp coated PLGA microspheres	1427:1455	nHAp coated PLGA microspheres	1427:1455	An increased concentration of either agarose or PEG-DA and incorporation of nHAp coated PLGA microspheres led to an increase in the elastic modulus.
33174770	9	62	theme	in	1636:1637	arg1	testing					1648:1654	in in-vitro testing	1636:1654	in in-vitro testing	1636:1654	The IPN hydrogel combinations supported the adhesion and proliferation of both fibroblast and ocular human keratocyte cell types during in in-vitro testing.
33174770	6	63	theme	cellular	1111:1118	arg1	response					1120:1127	cellular response	1111:1127	cellular response	1111:1127	The incorporation of nHAp coated PLGA microspheres into the hybrid IPN network provide a micro-environment similar to that of skeletal tissues and improve cellular response.
33174770	7	64	with	network	1250:1256	arg1	%					1300:1300	20 and 40 wt %	1287:1300	20 and 40 wt %	1287:1300	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	7	64	with	network	1250:1256	arg1	concentrations					1271:1284	varying concentrations	1263:1284	varying concentrations (20 and 40 wt %)	1263:1301	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	2	65	theme	autologous	349:358	arg1	material					376:383	autologous dental laminate material	349:383	autologous dental laminate material	349:383	However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexity and skirt erosion.
33174770	7	66	theme	second	1243:1248	arg1	network					1250:1256	a second network	1241:1256	a second network with varying concentrations (20 and 40 wt %)	1241:1301	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	7	66	theme	second	1243:1248	arg1	PEGDA					1213:1217	PEGDA	1213:1217	PEGDA (6000 Da)	1213:1227	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	5	67	theme	high	671:674	arg1	composite					725:733	A novel high strength interpenetrating network (IPN) hydrogel composite	663:733	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	663:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	9	68	theme	human	1601:1605	arg1	types					1623:1627	both fibroblast and ocular human keratocyte cell types	1574:1627	types	1623:1627	The IPN hydrogel combinations supported the adhesion and proliferation of both fibroblast and ocular human keratocyte cell types during in in-vitro testing.
33174770	9	69	theme	hydrogel	1508:1515	arg1	combinations					1517:1528	The IPN hydrogel combinations	1500:1528	The IPN hydrogel combinations	1500:1528	The IPN hydrogel combinations supported the adhesion and proliferation of both fibroblast and ocular human keratocyte cell types during in in-vitro testing.
33174770	10	70	theme	coated	1787:1792	arg1	microspheres					1794:1805	nHAp coated microspheres	1782:1805	nHAp coated microspheres	1782:1805	The cells endured the encapsulation process into the IPN and remained viable at 1 week post-encapsulation in the presence of nHAp coated microspheres.
33174770	12	71	theme	encapsulated	1984:1995	arg1	supportive					2051:2060	supportive	2051:2060	supportive	2051:2060	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	12	71	theme	encapsulated	1984:1995	arg1	hydrogels					2011:2019	The nHAp encapsulated composite IPN hydrogels	1975:2019	The nHAp encapsulated composite IPN hydrogels	1975:2019	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	6	72	theme	coated	982:987	arg1	microspheres					994:1005	nHAp coated PLGA microspheres	977:1005	nHAp coated PLGA microspheres	977:1005	The incorporation of nHAp coated PLGA microspheres into the hybrid IPN network provide a micro-environment similar to that of skeletal tissues and improve cellular response.
33174770	10	73	theme	nHAp	1782:1785	arg1	microspheres					1794:1805	nHAp coated microspheres	1782:1805	nHAp coated microspheres	1782:1805	The cells endured the encapsulation process into the IPN and remained viable at 1 week post-encapsulation in the presence of nHAp coated microspheres.
33174770	8	74	theme	PLGA	1439:1442	arg1	microspheres					1444:1455	nHAp coated PLGA microspheres	1427:1455	nHAp coated PLGA microspheres	1427:1455	An increased concentration of either agarose or PEG-DA and incorporation of nHAp coated PLGA microspheres led to an increase in the elastic modulus.
33174770	9	75	dep	in	1636:1637	arg1	in-vitro					1639:1646	in-vitro	1639:1646	in-vitro	1639:1646	The IPN hydrogel combinations supported the adhesion and proliferation of both fibroblast and ocular human keratocyte cell types during in in-vitro testing.
33174770	11	76	theme	cytokine	1875:1882	arg1	IL-6					1884:1887	inflammatory cytokine IL-6	1862:1887	inflammatory cytokine IL-6	1862:1887	The material did not induce significant production of inflammatory cytokine IL-6 in comparison to a positive control (p < 0.05) indicating non-inflammatory potential.
33174770	5	77	theme	alveo-dental	860:871	arg1	lamina					873:878	the alveo-dental lamina	856:878	the alveo-dental lamina	856:878	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	12	78	theme	new	2153:2155	arg1	approach					2157:2164	a new approach	2151:2164	a new approach to dental laminate biomimicry in the OOKP skirt material	2151:2221	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	11	79	theme	significant	1836:1846	arg1	production					1848:1857	significant production	1836:1857	significant production of inflammatory cytokine IL-6	1836:1887	The material did not induce significant production of inflammatory cytokine IL-6 in comparison to a positive control (p < 0.05) indicating non-inflammatory potential.
33174770	5	80	theme	interpenetrating	685:700	arg1	composite					725:733	A novel high strength interpenetrating network (IPN) hydrogel composite	663:733	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	663:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	1	81	theme	anchoring	160:168	arg1	material					145:152	dental laminate material	129:152	dental laminate material	129:152	Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years.
33174770	1	81	theme	anchoring	160:168	arg1	skirt					170:174	an anchoring skirt	157:174	an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic	157:230	Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years.
33174770	12	82	dep	biomimicry	2185:2194	arg1	laminate					2176:2183	laminate	2176:2183	laminate	2176:2183	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	1	83	theme	central	185:191	arg1	poly					193:196	a central poly	183:196	a central poly(methyl methacrylate) (PMMA) optic	183:230	Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years.
33174770	1	83	theme	central	185:191	arg1	methacrylate					205:216	methyl methacrylate	198:216	methyl methacrylate	198:216	Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years.
33174770	1	83	theme	central	185:191	arg1	PMMA					220:223	PMMA	220:223	PMMA	220:223	Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years.
33174770	6	84	theme	IPN	1023:1025	arg1	network					1027:1033	the hybrid IPN network	1012:1033	the hybrid IPN network	1012:1033	The incorporation of nHAp coated PLGA microspheres into the hybrid IPN network provide a micro-environment similar to that of skeletal tissues and improve cellular response.
33174770	8	85	theme	elastic	1483:1489	arg1	modulus					1491:1497	the elastic modulus	1479:1497	the elastic modulus	1479:1497	An increased concentration of either agarose or PEG-DA and incorporation of nHAp coated PLGA microspheres led to an increase in the elastic modulus.
33174770	7	86	theme	biocompatible	1327:1339	arg1	scaffold					1341:1348	a strong and biocompatible scaffold	1314:1348	a strong and biocompatible scaffold	1314:1348	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	8	87	from	increase	1467:1474	arg1	modulus					1491:1497	the elastic modulus	1479:1497	the elastic modulus	1479:1497	An increased concentration of either agarose or PEG-DA and incorporation of nHAp coated PLGA microspheres led to an increase in the elastic modulus.
33174770	5	88	theme	poly	786:789	arg1	microspheres					822:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	5	89	theme	ethylene	910:917	arg1	poly					905:908	poly	905:908	poly(ethylene glycol)	905:925	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	5	89	theme	ethylene	910:917	arg1	glycol					919:924	ethylene glycol	910:924	ethylene glycol	910:924	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	1	90	dep	material	145:152	arg1	laminate					136:143	laminate	136:143	laminate	136:143	Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years.
33174770	5	91	theme	nano-crystalline	740:755	arg1	microspheres					822:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	6	92	theme	microspheres	994:1005	arg1	incorporation					960:972	The incorporation	956:972	The incorporation of nHAp coated PLGA microspheres into the hybrid IPN network	956:1033	The incorporation of nHAp coated PLGA microspheres into the hybrid IPN network provide a micro-environment similar to that of skeletal tissues and improve cellular response.
33174770	2	93	theme	surgical	386:393	arg1	complexity					395:404	surgical complexity	386:404	surgical complexity	386:404	However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexity and skirt erosion.
33174770	0	94	theme	bone-like	11:19	arg1	composites					21:30	Biomimetic bone-like composites	0:30	Biomimetic bone-like composites as osteo-odonto-keratoprosthesis	0:63	Biomimetic bone-like composites as osteo-odonto-keratoprosthesis skirt substitutes.
33174770	3	95	theme	engineering	432:442	arg1	approaches					444:453	Tissue engineering approaches	425:453	Tissue engineering approaches to bone replacement	425:473	Tissue engineering approaches to bone replacement may offer suitable alternatives in osteo-odonto-keratoprosthesis (OOKP) surgery.
33174770	12	96	theme	skirt	2208:2212	arg1	material					2214:2221	the OOKP skirt material	2199:2221	the OOKP skirt material	2199:2221	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	5	97	with	composite	725:733	arg1	microspheres					822:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres	740:833	A novel high strength interpenetrating network (IPN) hydrogel composite with nano-crystalline hydroxyapatite (nHAp) coated poly (lactic-co-glycolic acid) PLGA microspheres was created to mimic the alveo-dental lamina by employing agarose and poly(ethylene glycol) diacrylate (PEGDA) polymers.
33174770	4	98	theme	polymer	582:588	arg1	synthetic					622:630	synthetic	622:630	synthetic	622:630	In this study, a hydrogel polymer composite was investigated as a synthetic substitute for the OOKP skirt.
33174770	4	98	theme	polymer	582:588	arg1	composite					590:598	a hydrogel polymer composite	571:598	a hydrogel polymer composite	571:598	In this study, a hydrogel polymer composite was investigated as a synthetic substitute for the OOKP skirt.
33174770	11	99	theme	non-inflammatory	1947:1962	arg1	potential					1964:1972	non-inflammatory potential	1947:1972	non-inflammatory potential	1947:1972	The material did not induce significant production of inflammatory cytokine IL-6 in comparison to a positive control (p < 0.05) indicating non-inflammatory potential.
33174770	7	100	theme	first	1152:1156	arg1	Agarose					1130:1136	Agarose	1130:1136	Agarose	1130:1136	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	7	100	theme	first	1152:1156	arg1	network					1158:1164	a first network	1150:1164	a first network	1150:1164	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	0	101	dep	skirt	65:69	arg1	substitutes					71:81	substitutes	71:81	skirt substitutes	65:81	Biomimetic bone-like composites as osteo-odonto-keratoprosthesis skirt substitutes.
33174770	3	102	theme	osteo-odonto-keratoprosthesis	510:538	arg1	surgery					547:553	osteo-odonto-keratoprosthesis (OOKP) surgery	510:553	osteo-odonto-keratoprosthesis (OOKP) surgery	510:553	Tissue engineering approaches to bone replacement may offer suitable alternatives in osteo-odonto-keratoprosthesis (OOKP) surgery.
33174770	9	103	theme	cell	1618:1621	arg1	types					1623:1627	both fibroblast and ocular human keratocyte cell types	1574:1627	types	1623:1627	The IPN hydrogel combinations supported the adhesion and proliferation of both fibroblast and ocular human keratocyte cell types during in in-vitro testing.
33174770	7	104	theme	varying	1263:1269	arg1	%					1300:1300	20 and 40 wt %	1287:1300	20 and 40 wt %	1287:1300	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	7	104	theme	varying	1263:1269	arg1	concentrations					1271:1284	varying concentrations	1263:1284	varying concentrations (20 and 40 wt %)	1263:1301	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
33174770	2	105	dep	material	376:383	arg1	laminate					367:374	laminate	367:374	laminate	367:374	However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexity and skirt erosion.
33174770	2	106	theme	dental	360:365	arg1	material					376:383	autologous dental laminate material	349:383	autologous dental laminate material	349:383	However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexity and skirt erosion.
33174770	6	107	theme	skeletal	1082:1089	arg1	tissues					1091:1097	skeletal tissues	1082:1097	skeletal tissues	1082:1097	The incorporation of nHAp coated PLGA microspheres into the hybrid IPN network provide a micro-environment similar to that of skeletal tissues and improve cellular response.
33174770	12	108	theme	OOKP	2203:2206	arg1	material					2214:2221	the OOKP skirt material	2199:2221	the OOKP skirt material	2199:2221	The nHAp encapsulated composite IPN hydrogels are mechanically strong, cell supportive, non-inflammatory materials supporting their development as OOKP skirt substitutes using a new approach to dental laminate biomimicry in the OOKP skirt material.
33174770	7	109	theme	keratocytes/3T3	1181:1195	arg1	fibroblasts					1197:1207	keratocytes/3T3 fibroblasts	1181:1207	keratocytes/3T3 fibroblasts	1181:1207	Agarose was used as a first network to encapsulate keratocytes/3T3 fibroblasts and PEGDA (6000 Da) was used as a second network with varying concentrations (20 and 40 wt %) to produce a strong and biocompatible scaffold.
32534084	2	0	theme	3D	409:410	arg1	nanocomposites					421:434	GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites	322:434	GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites	322:434	In this study, 3D nanostructures with GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites were designed.
32534084	5	1	theme	mesoporous	791:800	arg1	structure					802:810	a mesoporous structure	789:810	a mesoporous structure with a pore volume of 0.72 cm3/g	789:843	The 3D nanocomposites showed a mesoporous structure with a pore volume of 0.72 cm3/g and a prevailing pore size distribution of about 10 nm.
32534084	4	2	located	observed	691:698	arg2	increase					678:685	an unprecedented ~3-fold increase	653:685	an unprecedented ~3-fold increase	653:685	Also, an unprecedented ~3-fold increase was observed in the surface area of 3D GO-CS/GA compared with single GO.
32534084	4	2	located	observed	691:698	arg1	area					715:718	the surface area	703:718	the surface area of 3D GO-CS/GA	703:733	Also, an unprecedented ~3-fold increase was observed in the surface area of 3D GO-CS/GA compared with single GO.
32534084	4	3	dep	single	749:754	arg1	GO					756:757	GO	756:757	GO	756:757	Also, an unprecedented ~3-fold increase was observed in the surface area of 3D GO-CS/GA compared with single GO.
32534084	5	4	with	structure	802:810	arg1	volume					824:829	a pore volume	817:829	a pore volume of 0.72 cm3/g	817:843	The 3D nanocomposites showed a mesoporous structure with a pore volume of 0.72 cm3/g and a prevailing pore size distribution of about 10 nm.
32534084	0	5	theme	gum	110:112	arg1	biopolymers					121:131	chitosan- gum Arabic biopolymers	100:131	chitosan- gum Arabic biopolymers	100:131	Preparation and characterization of 3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers.
32534084	4	6	theme	GO-CS/GA	726:733	arg1	area					715:718	the surface area	703:718	the surface area of 3D GO-CS/GA	703:733	Also, an unprecedented ~3-fold increase was observed in the surface area of 3D GO-CS/GA compared with single GO.
32534084	4	7	theme	~3-fold	670:676	arg1	increase					678:685	an unprecedented ~3-fold increase	653:685	an unprecedented ~3-fold increase	653:685	Also, an unprecedented ~3-fold increase was observed in the surface area of 3D GO-CS/GA compared with single GO.
32534084	0	8	theme	chitosan-	100:108	arg1	biopolymers					121:131	chitosan- gum Arabic biopolymers	100:131	chitosan- gum Arabic biopolymers	100:131	Preparation and characterization of 3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers.
32534084	4	9	theme	unprecedented	656:668	arg1	increase					678:685	an unprecedented ~3-fold increase	653:685	an unprecedented ~3-fold increase	653:685	Also, an unprecedented ~3-fold increase was observed in the surface area of 3D GO-CS/GA compared with single GO.
32534084	1	10	dep	oxide	152:156	arg1	GO					159:160	GO	159:160	GO	159:160	Although graphene oxide (GO) is a good adsorber, it has a low stability in pure form which can be improved by the development of GO-based composites.
32534084	0	11	theme	biopolymers	121:131	arg1	nanocomplexes					83:95	nanocomplexes	83:95	nanocomplexes of chitosan- gum Arabic biopolymers	83:131	Preparation and characterization of 3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers.
32534084	7	12	theme	synthesized	993:1003	arg1	nanostructures					1005:1018	The synthesized nanostructures	989:1018	The synthesized nanostructures	989:1018	The synthesized nanostructures would be of profound interest for numerous areas including adsorption processes.
32534084	0	13	with	embedded	69:76	arg1	nanocomplexes					83:95	nanocomplexes	83:95	nanocomplexes of chitosan- gum Arabic biopolymers	83:131	Preparation and characterization of 3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers.
32534084	3	14	theme	instrumental	455:466	arg1	analysis					468:475	The instrumental analysis	451:475	The instrumental analysis	451:475	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32534084	0	15	theme	Arabic	114:119	arg1	biopolymers					121:131	chitosan- gum Arabic biopolymers	100:131	chitosan- gum Arabic biopolymers	100:131	Preparation and characterization of 3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers.
32534084	7	16	theme	numerous	1054:1061	arg1	areas					1063:1067	numerous areas	1054:1067	numerous areas including adsorption processes	1054:1098	The synthesized nanostructures would be of profound interest for numerous areas including adsorption processes.
32534084	7	16	theme	numerous	1054:1061	arg1	processes					1090:1098	adsorption processes	1079:1098	adsorption processes	1079:1098	The synthesized nanostructures would be of profound interest for numerous areas including adsorption processes.
32534084	2	17	dep	GO	322:323	arg1	surface-decorated					326:342	surface-decorated	326:342	surface-decorated	326:342	In this study, 3D nanostructures with GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites were designed.
32534084	2	17	dep	GO	322:323	arg1	called					402:407	called	402:407	called	402:407	In this study, 3D nanostructures with GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites were designed.
32534084	1	18	theme	good	168:171	arg1	adsorber					173:180	a good adsorber	166:180	a good adsorber	166:180	Although graphene oxide (GO) is a good adsorber, it has a low stability in pure form which can be improved by the development of GO-based composites.
32534084	1	18	theme	good	168:171	arg1	oxide					152:156	graphene oxide	143:156	graphene oxide (GO)	143:161	Although graphene oxide (GO) is a good adsorber, it has a low stability in pure form which can be improved by the development of GO-based composites.
32534084	5	19	theme	10 nm	894:898	arg1	structure					802:810	a mesoporous structure	789:810	a mesoporous structure with a pore volume of 0.72 cm3/g	789:843	The 3D nanocomposites showed a mesoporous structure with a pore volume of 0.72 cm3/g and a prevailing pore size distribution of about 10 nm.
32534084	5	19	theme	10 nm	894:898	arg1	distribution					872:883	a prevailing pore size distribution	849:883	a prevailing pore size distribution of about 10 nm	849:898	The 3D nanocomposites showed a mesoporous structure with a pore volume of 0.72 cm3/g and a prevailing pore size distribution of about 10 nm.
32534084	3	20	theme	complexes	506:514	arg1	interaction					491:501	the interaction	487:501	the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm	487:644	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32534084	5	21	theme	3D	764:765	arg1	nanocomposites					767:780	The 3D nanocomposites	760:780	The 3D nanocomposites	760:780	The 3D nanocomposites showed a mesoporous structure with a pore volume of 0.72 cm3/g and a prevailing pore size distribution of about 10 nm.
32534084	2	22	theme	Arabic	386:391	arg1	nanocomplexes					347:359	nanocomplexes	347:359	nanocomplexes of chitosan (CS) and gum Arabic (GA)	347:396	In this study, 3D nanostructures with GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites were designed.
32534084	5	23	theme	0.72 cm3/g	834:843	arg1	volume					824:829	a pore volume	817:829	a pore volume of 0.72 cm3/g	817:843	The 3D nanocomposites showed a mesoporous structure with a pore volume of 0.72 cm3/g and a prevailing pore size distribution of about 10 nm.
32534084	7	24	theme	profound	1032:1039	arg1	interest					1041:1048	profound interest	1032:1048	profound interest	1032:1048	The synthesized nanostructures would be of profound interest for numerous areas including adsorption processes.
32534084	2	25	theme	gum	382:384	arg1	Arabic					386:391	gum Arabic	382:391	gum Arabic (GA)	382:396	In this study, 3D nanostructures with GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites were designed.
32534084	2	25	theme	gum	382:384	arg1	GA					394:395	GA	394:395	GA	394:395	In this study, 3D nanostructures with GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites were designed.
32534084	4	26	theme	surface	707:713	arg1	area					715:718	the surface area	703:718	the surface area of 3D GO-CS/GA	703:733	Also, an unprecedented ~3-fold increase was observed in the surface area of 3D GO-CS/GA compared with single GO.
32534084	4	27	theme	3D	723:724	arg1	GO-CS/GA					726:733	3D GO-CS/GA	723:733	3D GO-CS/GA	723:733	Also, an unprecedented ~3-fold increase was observed in the surface area of 3D GO-CS/GA compared with single GO.
32534084	3	28	from	8.1 nm	639:644	arg1	thickness					617:625	thickness	617:625	thickness from 1.0 to 8.1 nm	617:644	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32534084	5	29	theme	size	867:870	arg1	distribution					872:883	a prevailing pore size distribution	849:883	a prevailing pore size distribution of about 10 nm	849:898	The 3D nanocomposites showed a mesoporous structure with a pore volume of 0.72 cm3/g and a prevailing pore size distribution of about 10 nm.
32534084	5	30	theme	pore	862:865	arg1	distribution					872:883	a prevailing pore size distribution	849:883	a prevailing pore size distribution of about 10 nm	849:898	The 3D nanocomposites showed a mesoporous structure with a pore volume of 0.72 cm3/g and a prevailing pore size distribution of about 10 nm.
32534084	0	31	theme	graphene	39:46	arg1	nanostructures					54:67	3D graphene oxide nanostructures	36:67	3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers	36:131	Preparation and characterization of 3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers.
32534084	3	32	theme	3D	592:593	arg1	sheets					595:600	3D sheets	592:600	3D sheets	592:600	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32534084	6	33	theme	charge	944:949	arg1	adjustability					905:917	The adjustability	901:917	The adjustability of nanocomposite surface charge over pH	901:957	The adjustability of nanocomposite surface charge over pH was another important result.
32534084	6	33	theme	charge	944:949	arg1	result					981:986	another important result	963:986	another important result	963:986	The adjustability of nanocomposite surface charge over pH was another important result.
32534084	0	34	theme	3D	36:37	arg1	nanostructures					54:67	3D graphene oxide nanostructures	36:67	3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers	36:131	Preparation and characterization of 3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers.
32534084	1	35	theme	GO-based	263:270	arg1	composites					272:281	GO-based composites	263:281	GO-based composites	263:281	Although graphene oxide (GO) is a good adsorber, it has a low stability in pure form which can be improved by the development of GO-based composites.
32534084	5	36	with	distribution	872:883	arg1	volume					824:829	a pore volume	817:829	a pore volume of 0.72 cm3/g	817:843	The 3D nanocomposites showed a mesoporous structure with a pore volume of 0.72 cm3/g and a prevailing pore size distribution of about 10 nm.
32534084	3	37	with	complexes	506:514	arg1	groups					543:548	oxygenated functional groups	521:548	oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm	521:644	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32534084	3	37	with	complexes	506:514	arg1	GO					553:554	GO	553:554	GO	553:554	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32534084	1	38	theme	low	192:194	arg1	stability					196:204	a low stability	190:204	a low stability in pure form which can be improved by the development of GO-based composites	190:281	Although graphene oxide (GO) is a good adsorber, it has a low stability in pure form which can be improved by the development of GO-based composites.
32534084	0	39	theme	nanostructures	54:67	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of 3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers.
32534084	0	39	theme	nanostructures	54:67	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of 3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers.
32534084	1	40	theme	composites	272:281	arg1	development					248:258	the development	244:258	the development of GO-based composites	244:281	Although graphene oxide (GO) is a good adsorber, it has a low stability in pure form which can be improved by the development of GO-based composites.
32534084	6	41	theme	surface	936:942	arg1	charge					944:949	nanocomposite surface charge	922:949	nanocomposite surface charge	922:949	The adjustability of nanocomposite surface charge over pH was another important result.
32534084	0	42	theme	embedded	69:76	arg1	nanostructures					54:67	3D graphene oxide nanostructures	36:67	3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers	36:131	Preparation and characterization of 3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers.
32534084	3	43	theme	oxygenated	521:530	arg1	groups					543:548	oxygenated functional groups	521:548	oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm	521:644	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32534084	3	43	theme	oxygenated	521:530	arg1	GO					553:554	GO	553:554	GO	553:554	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32534084	2	44	theme	3D	299:300	arg1	nanostructures					302:315	3D nanostructures	299:315	3D nanostructures with GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites	299:434	In this study, 3D nanostructures with GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites were designed.
32534084	0	45	theme	oxide	48:52	arg1	nanostructures					54:67	3D graphene oxide nanostructures	36:67	3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers	36:131	Preparation and characterization of 3D graphene oxide nanostructures embedded with nanocomplexes of chitosan- gum Arabic biopolymers.
32534084	3	46	theme	functional	532:541	arg1	groups					543:548	oxygenated functional groups	521:548	oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm	521:644	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32534084	3	46	theme	functional	532:541	arg1	GO					553:554	GO	553:554	GO	553:554	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32534084	3	47	dep	8.1 nm	639:644	arg1	to					636:637	to	636:637	to	636:637	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32534084	1	48	from	stability	196:204	arg1	form					214:217	pure form	209:217	pure form	209:217	Although graphene oxide (GO) is a good adsorber, it has a low stability in pure form which can be improved by the development of GO-based composites.
32534084	2	49	with	nanostructures	302:315	arg1	nanocomposites					421:434	GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites	322:434	GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites	322:434	In this study, 3D nanostructures with GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites were designed.
32534084	1	50	theme	graphene	143:150	arg1	adsorber					173:180	a good adsorber	166:180	a good adsorber	166:180	Although graphene oxide (GO) is a good adsorber, it has a low stability in pure form which can be improved by the development of GO-based composites.
32534084	1	50	theme	graphene	143:150	arg1	oxide					152:156	graphene oxide	143:156	graphene oxide (GO)	143:161	Although graphene oxide (GO) is a good adsorber, it has a low stability in pure form which can be improved by the development of GO-based composites.
32534084	6	51	theme	nanocomposite	922:934	arg1	charge					944:949	nanocomposite surface charge	922:949	nanocomposite surface charge	922:949	The adjustability of nanocomposite surface charge over pH was another important result.
32534084	1	52	contain	has	186:188	arg2	stability					196:204	a low stability	190:204	a low stability in pure form which can be improved by the development of GO-based composites	190:281	Although graphene oxide (GO) is a good adsorber, it has a low stability in pure form which can be improved by the development of GO-based composites.
32534084	1	52	contain	has	186:188	arg1	it					183:184	it	183:184	it	183:184	Although graphene oxide (GO) is a good adsorber, it has a low stability in pure form which can be improved by the development of GO-based composites.
32534084	5	53	theme	prevailing	851:860	arg1	distribution					872:883	a prevailing pore size distribution	849:883	a prevailing pore size distribution of about 10 nm	849:898	The 3D nanocomposites showed a mesoporous structure with a pore volume of 0.72 cm3/g and a prevailing pore size distribution of about 10 nm.
32534084	5	54	theme	pore	819:822	arg1	volume					824:829	a pore volume	817:829	a pore volume of 0.72 cm3/g	817:843	The 3D nanocomposites showed a mesoporous structure with a pore volume of 0.72 cm3/g and a prevailing pore size distribution of about 10 nm.
32534084	2	55	theme	chitosan	364:371	arg1	nanocomplexes					347:359	nanocomplexes	347:359	nanocomplexes of chitosan (CS) and gum Arabic (GA)	347:396	In this study, 3D nanostructures with GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites were designed.
32534084	3	56	theme	GO	553:554	arg1	groups					543:548	oxygenated functional groups	521:548	oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm	521:644	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32534084	3	56	theme	GO	553:554	arg1	GO					553:554	GO	553:554	GO	553:554	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32534084	6	57	theme	important	971:979	arg1	adjustability					905:917	The adjustability	901:917	The adjustability of nanocomposite surface charge over pH	901:957	The adjustability of nanocomposite surface charge over pH was another important result.
32534084	6	57	theme	important	971:979	arg1	result					981:986	another important result	963:986	another important result	963:986	The adjustability of nanocomposite surface charge over pH was another important result.
32534084	1	58	theme	pure	209:212	arg1	form					214:217	pure form	209:217	pure form	209:217	Although graphene oxide (GO) is a good adsorber, it has a low stability in pure form which can be improved by the development of GO-based composites.
32534084	2	59	theme	GO-CS/GA	412:419	arg1	nanocomposites					421:434	GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites	322:434	GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites	322:434	In this study, 3D nanostructures with GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites were designed.
32534084	7	60	theme	adsorption	1079:1088	arg1	processes					1090:1098	adsorption processes	1079:1098	adsorption processes	1079:1098	The synthesized nanostructures would be of profound interest for numerous areas including adsorption processes.
32534084	2	61	theme	GO	322:323	arg1	nanocomposites					421:434	GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites	322:434	GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites	322:434	In this study, 3D nanostructures with GO, surface-decorated by nanocomplexes of chitosan (CS) and gum Arabic (GA), so called 3D GO-CS/GA nanocomposites were designed.
32534084	3	62	from	d-spacing	579:587	arg1	sheets					595:600	3D sheets	592:600	3D sheets	592:600	The instrumental analysis confirmed the interaction of complexes with oxygenated functional groups of GO which improved both of d-spacing in 3D sheets by 16%, and GO thickness from 1.0 to 8.1 nm.
32960791	4	0	theme	CS	745:746	arg1	sub-layer					758:766	the CS composite sub-layer	741:766	the CS composite sub-layer	741:766	It was found that the addition of MT clay within the CS composite sub-layer improved the mechanical strength of CS, reduced its swelling and shifted its absorption threshold to higher wavelengths.
32960791	6	1	theme	due	1126:1128	arg1	TiO2					1121:1124	the single TiO2	1110:1124	the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer	1110:1213	The immobilized TiO2/CS-MT exhibited methyl orange (MO) decolourization rate of 0.071 min-1 under light irradiation, which is better than the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer.
32960791	1	2	theme	large-scale	193:203	arg1	applications					205:216	large-scale applications	193:216	large-scale applications	193:216	Many attempts have been made to improve the photocatalytic performance of immobilized photocatalysts for large-scale applications by modification of the photocatalyst properties.
32960791	4	3	theme	MT	726:727	arg1	clay					729:732	MT clay	726:732	MT clay	726:732	It was found that the addition of MT clay within the CS composite sub-layer improved the mechanical strength of CS, reduced its swelling and shifted its absorption threshold to higher wavelengths.
32960791	6	4	theme	decolourization	1028:1042	arg1	rate					1044:1047	methyl orange (MO) decolourization rate	1009:1047	methyl orange (MO) decolourization rate of 0.071 min-1	1009:1062	The immobilized TiO2/CS-MT exhibited methyl orange (MO) decolourization rate of 0.071 min-1 under light irradiation, which is better than the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer.
32960791	7	5	theme	complete	1247:1254	arg1	mineralization					1256:1269	complete mineralization	1247:1269	complete mineralization	1247:1269	The MO dye took 6 h to achieve complete mineralization and produced sulfate and nitrate ions as the by-products.
32960791	4	6	theme	mechanical	781:790	arg1	strength					792:799	the mechanical strength	777:799	the mechanical strength of CS	777:805	It was found that the addition of MT clay within the CS composite sub-layer improved the mechanical strength of CS, reduced its swelling and shifted its absorption threshold to higher wavelengths.
32960791	6	7	theme	adsorption	1162:1171	arg1	processes					1149:1157	the synergistic processes	1133:1157	the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer	1133:1213	The immobilized TiO2/CS-MT exhibited methyl orange (MO) decolourization rate of 0.071 min-1 under light irradiation, which is better than the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer.
32960791	3	8	theme	photocatalysis	532:545	arg1	processes					547:555	adsorption and photocatalysis processes	517:555	processes	547:555	This arrangement allows a simultaneous occurrence of adsorption and photocatalysis processes of pollutants, whereby each layer could be independently modified and controlled to acquire the desired degree of occurring processes.
32960791	2	9	theme	titanium	327:334	arg1	dioxide					336:342	titanium dioxide	327:342	titanium dioxide (TiO2)	327:349	In this work, immobilized bilayer photocatalyst composed of titanium dioxide (TiO2) and chitosan-montmorillonite (CS-MT) were prepared in a layer-by-layer arrangement supported on glass substrate.
32960791	2	9	theme	titanium	327:334	arg1	TiO2					345:348	TiO2	345:348	TiO2	345:348	In this work, immobilized bilayer photocatalyst composed of titanium dioxide (TiO2) and chitosan-montmorillonite (CS-MT) were prepared in a layer-by-layer arrangement supported on glass substrate.
32960791	2	10	theme	glass	447:451	arg1	substrate					453:461	glass substrate	447:461	glass substrate	447:461	In this work, immobilized bilayer photocatalyst composed of titanium dioxide (TiO2) and chitosan-montmorillonite (CS-MT) were prepared in a layer-by-layer arrangement supported on glass substrate.
32960791	7	11	theme	MO	1220:1221	arg1	dye					1223:1225	The MO dye	1216:1225	The MO dye	1216:1225	The MO dye took 6 h to achieve complete mineralization and produced sulfate and nitrate ions as the by-products.
32960791	6	12	theme	single	1114:1119	arg1	TiO2					1121:1124	the single TiO2	1110:1124	the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer	1110:1213	The immobilized TiO2/CS-MT exhibited methyl orange (MO) decolourization rate of 0.071 min-1 under light irradiation, which is better than the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer.
32960791	4	13	theme	CS	804:805	arg1	strength					792:799	the mechanical strength	777:799	the mechanical strength of CS	777:805	It was found that the addition of MT clay within the CS composite sub-layer improved the mechanical strength of CS, reduced its swelling and shifted its absorption threshold to higher wavelengths.
32960791	6	14	theme	MO	1024:1025	arg1	rate					1044:1047	methyl orange (MO) decolourization rate	1009:1047	methyl orange (MO) decolourization rate of 0.071 min-1	1009:1062	The immobilized TiO2/CS-MT exhibited methyl orange (MO) decolourization rate of 0.071 min-1 under light irradiation, which is better than the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer.
32960791	5	15	theme	gap	911:913	arg1	energy					915:920	the band gap energy	902:920	the band gap energy of the photocatalyst	902:941	In addition, the band gap energy of the photocatalyst was also reduced to 2.93 eV.
32960791	4	16	theme	clay	729:732	arg1	addition					714:721	the addition	710:721	the addition of MT clay within the CS composite sub-layer	710:766	It was found that the addition of MT clay within the CS composite sub-layer improved the mechanical strength of CS, reduced its swelling and shifted its absorption threshold to higher wavelengths.
32960791	0	17	theme	methyl	28:33	arg1	orange					35:40	methyl orange	28:40	methyl orange	28:40	Enhanced decolourization of methyl orange by immobilized TiO2/chitosan-montmorillonite.
32960791	3	18	theme	processes	681:689	arg1	degree					661:666	the desired degree	649:666	the desired degree of occurring processes	649:689	This arrangement allows a simultaneous occurrence of adsorption and photocatalysis processes of pollutants, whereby each layer could be independently modified and controlled to acquire the desired degree of occurring processes.
32960791	6	19	theme	synergistic	1137:1147	arg1	processes					1149:1157	the synergistic processes	1133:1157	the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer	1133:1213	The immobilized TiO2/CS-MT exhibited methyl orange (MO) decolourization rate of 0.071 min-1 under light irradiation, which is better than the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer.
32960791	6	20	theme	orange	1016:1021	arg1	rate					1044:1047	methyl orange (MO) decolourization rate	1009:1047	methyl orange (MO) decolourization rate of 0.071 min-1	1009:1062	The immobilized TiO2/CS-MT exhibited methyl orange (MO) decolourization rate of 0.071 min-1 under light irradiation, which is better than the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer.
32960791	6	21	theme	TiO2	1204:1207	arg1	layer					1209:1213	TiO2 layer	1204:1213	TiO2 layer	1204:1213	The immobilized TiO2/CS-MT exhibited methyl orange (MO) decolourization rate of 0.071 min-1 under light irradiation, which is better than the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer.
32960791	4	22	theme	composite	748:756	arg1	sub-layer					758:766	the CS composite sub-layer	741:766	the CS composite sub-layer	741:766	It was found that the addition of MT clay within the CS composite sub-layer improved the mechanical strength of CS, reduced its swelling and shifted its absorption threshold to higher wavelengths.
32960791	1	23	theme	photocatalyst	241:253	arg1	properties					255:264	the photocatalyst properties	237:264	the photocatalyst properties	237:264	Many attempts have been made to improve the photocatalytic performance of immobilized photocatalysts for large-scale applications by modification of the photocatalyst properties.
32960791	6	24	theme	methyl	1009:1014	arg1	rate					1044:1047	methyl orange (MO) decolourization rate	1009:1047	methyl orange (MO) decolourization rate of 0.071 min-1	1009:1062	The immobilized TiO2/CS-MT exhibited methyl orange (MO) decolourization rate of 0.071 min-1 under light irradiation, which is better than the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer.
32960791	8	25	theme	activity	1456:1463	arg1	loss					1444:1447	significant loss	1432:1447	significant loss of its activity	1432:1463	Furthermore, the immobilized TiO2/CS-MT could be reused for at least ten cycles of application without significant loss of its activity.
32960791	1	26	theme	properties	255:264	arg1	modification					221:232	modification	221:232	modification of the photocatalyst properties	221:264	Many attempts have been made to improve the photocatalytic performance of immobilized photocatalysts for large-scale applications by modification of the photocatalyst properties.
32960791	0	27	theme	orange	35:40	arg1	decolourization					9:23	decolourization	9:23	decolourization of methyl orange	9:40	Enhanced decolourization of methyl orange by immobilized TiO2/chitosan-montmorillonite.
32960791	3	28	theme	occurring	671:679	arg1	processes					681:689	occurring processes	671:689	occurring processes	671:689	This arrangement allows a simultaneous occurrence of adsorption and photocatalysis processes of pollutants, whereby each layer could be independently modified and controlled to acquire the desired degree of occurring processes.
32960791	3	29	theme	adsorption	517:526	arg1	processes					547:555	adsorption and photocatalysis processes	517:555	processes	547:555	This arrangement allows a simultaneous occurrence of adsorption and photocatalysis processes of pollutants, whereby each layer could be independently modified and controlled to acquire the desired degree of occurring processes.
32960791	5	30	theme	photocatalyst	929:941	arg1	energy					915:920	the band gap energy	902:920	the band gap energy of the photocatalyst	902:941	In addition, the band gap energy of the photocatalyst was also reduced to 2.93 eV.
32960791	3	31	theme	simultaneous	490:501	arg1	occurrence					503:512	a simultaneous occurrence	488:512	a simultaneous occurrence	488:512	This arrangement allows a simultaneous occurrence of adsorption and photocatalysis processes of pollutants, whereby each layer could be independently modified and controlled to acquire the desired degree of occurring processes.
32960791	3	32	theme	desired	653:659	arg1	degree					661:666	the desired degree	649:666	the desired degree of occurring processes	649:689	This arrangement allows a simultaneous occurrence of adsorption and photocatalysis processes of pollutants, whereby each layer could be independently modified and controlled to acquire the desired degree of occurring processes.
32960791	3	33	theme	pollutants	560:569	arg1	processes					547:555	adsorption and photocatalysis processes	517:555	processes	547:555	This arrangement allows a simultaneous occurrence of adsorption and photocatalysis processes of pollutants, whereby each layer could be independently modified and controlled to acquire the desired degree of occurring processes.
32960791	0	34	theme	immobilized	45:55	arg1	TiO2/chitosan-montmorillonite					57:85	immobilized TiO2/chitosan-montmorillonite	45:85	immobilized TiO2/chitosan-montmorillonite	45:85	Enhanced decolourization of methyl orange by immobilized TiO2/chitosan-montmorillonite.
32960791	6	35	theme	immobilized	976:986	arg1	TiO2/CS-MT					988:997	The immobilized TiO2/CS-MT	972:997	The immobilized TiO2/CS-MT	972:997	The immobilized TiO2/CS-MT exhibited methyl orange (MO) decolourization rate of 0.071 min-1 under light irradiation, which is better than the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer.
32960791	8	36	theme	application	1412:1422	arg1	cycles					1402:1407	at least ten cycles	1389:1407	at least ten cycles of application	1389:1422	Furthermore, the immobilized TiO2/CS-MT could be reused for at least ten cycles of application without significant loss of its activity.
32960791	7	37	theme	nitrate	1296:1302	arg1	by-products					1316:1326	the by-products	1312:1326	the by-products	1312:1326	The MO dye took 6 h to achieve complete mineralization and produced sulfate and nitrate ions as the by-products.
32960791	7	37	theme	nitrate	1296:1302	arg1	ions					1304:1307	sulfate and nitrate ions	1284:1307	sulfate and nitrate ions	1284:1307	The MO dye took 6 h to achieve complete mineralization and produced sulfate and nitrate ions as the by-products.
32960791	1	38	theme	photocatalytic	132:145	arg1	performance					147:157	the photocatalytic performance	128:157	the photocatalytic performance of immobilized photocatalysts for large-scale applications	128:216	Many attempts have been made to improve the photocatalytic performance of immobilized photocatalysts for large-scale applications by modification of the photocatalyst properties.
32960791	1	39	theme	immobilized	162:172	arg1	photocatalysts					174:187	immobilized photocatalysts	162:187	immobilized photocatalysts	162:187	Many attempts have been made to improve the photocatalytic performance of immobilized photocatalysts for large-scale applications by modification of the photocatalyst properties.
32960791	4	40	theme	absorption	845:854	arg1	threshold					856:864	its absorption threshold	841:864	its absorption threshold	841:864	It was found that the addition of MT clay within the CS composite sub-layer improved the mechanical strength of CS, reduced its swelling and shifted its absorption threshold to higher wavelengths.
32960791	4	41	theme	higher	869:874	arg1	wavelengths					876:886	higher wavelengths	869:886	higher wavelengths	869:886	It was found that the addition of MT clay within the CS composite sub-layer improved the mechanical strength of CS, reduced its swelling and shifted its absorption threshold to higher wavelengths.
32960791	3	42	theme	processes	547:555	arg1	occurrence					503:512	a simultaneous occurrence	488:512	a simultaneous occurrence	488:512	This arrangement allows a simultaneous occurrence of adsorption and photocatalysis processes of pollutants, whereby each layer could be independently modified and controlled to acquire the desired degree of occurring processes.
32960791	6	43	theme	light	1070:1074	arg1	irradiation					1076:1086	light irradiation	1070:1086	light irradiation	1070:1086	The immobilized TiO2/CS-MT exhibited methyl orange (MO) decolourization rate of 0.071 min-1 under light irradiation, which is better than the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer.
32960791	8	44	theme	significant	1432:1442	arg1	loss					1444:1447	significant loss	1432:1447	significant loss of its activity	1432:1463	Furthermore, the immobilized TiO2/CS-MT could be reused for at least ten cycles of application without significant loss of its activity.
32960791	1	45	dep	Many	88:91	arg1	attempts					93:100	attempts	93:100	attempts	93:100	Many attempts have been made to improve the photocatalytic performance of immobilized photocatalysts for large-scale applications by modification of the photocatalyst properties.
32960791	8	46	theme	immobilized	1346:1356	arg1	TiO2/CS-MT					1358:1367	the immobilized TiO2/CS-MT	1342:1367	the immobilized TiO2/CS-MT	1342:1367	Furthermore, the immobilized TiO2/CS-MT could be reused for at least ten cycles of application without significant loss of its activity.
32960791	7	47	theme	sulfate	1284:1290	arg1	by-products					1316:1326	the by-products	1312:1326	the by-products	1312:1326	The MO dye took 6 h to achieve complete mineralization and produced sulfate and nitrate ions as the by-products.
32960791	7	47	theme	sulfate	1284:1290	arg1	ions					1304:1307	sulfate and nitrate ions	1284:1307	sulfate and nitrate ions	1284:1307	The MO dye took 6 h to achieve complete mineralization and produced sulfate and nitrate ions as the by-products.
32960791	5	48	theme	band	906:909	arg1	energy					915:920	the band gap energy	902:920	the band gap energy of the photocatalyst	902:941	In addition, the band gap energy of the photocatalyst was also reduced to 2.93 eV.
32960791	2	49	theme	bilayer	293:299	arg1	photocatalyst					301:313	immobilized bilayer photocatalyst	281:313	immobilized bilayer photocatalyst composed of titanium dioxide (TiO2) and chitosan-montmorillonite (CS-MT)	281:386	In this work, immobilized bilayer photocatalyst composed of titanium dioxide (TiO2) and chitosan-montmorillonite (CS-MT) were prepared in a layer-by-layer arrangement supported on glass substrate.
32960791	2	50	theme	layer-by-layer	407:420	arg1	arrangement					422:432	a layer-by-layer arrangement	405:432	a layer-by-layer arrangement supported on glass substrate	405:461	In this work, immobilized bilayer photocatalyst composed of titanium dioxide (TiO2) and chitosan-montmorillonite (CS-MT) were prepared in a layer-by-layer arrangement supported on glass substrate.
32960791	6	51	theme	min-1	1058:1062	arg1	rate					1044:1047	methyl orange (MO) decolourization rate	1009:1047	methyl orange (MO) decolourization rate of 0.071 min-1	1009:1062	The immobilized TiO2/CS-MT exhibited methyl orange (MO) decolourization rate of 0.071 min-1 under light irradiation, which is better than the single TiO2 due to the synergistic processes of adsorption by CS-MT and photocatalysis by TiO2 layer.
32960791	2	52	theme	immobilized	281:291	arg1	photocatalyst					301:313	immobilized bilayer photocatalyst	281:313	immobilized bilayer photocatalyst composed of titanium dioxide (TiO2) and chitosan-montmorillonite (CS-MT)	281:386	In this work, immobilized bilayer photocatalyst composed of titanium dioxide (TiO2) and chitosan-montmorillonite (CS-MT) were prepared in a layer-by-layer arrangement supported on glass substrate.
32960791	1	53	theme	photocatalysts	174:187	arg1	performance					147:157	the photocatalytic performance	128:157	the photocatalytic performance of immobilized photocatalysts for large-scale applications	128:216	Many attempts have been made to improve the photocatalytic performance of immobilized photocatalysts for large-scale applications by modification of the photocatalyst properties.
32208927	0	0	from	sugarcane	27:35	arg1	Xylo-oligosaccharides					0:20	Xylo-oligosaccharides	0:20	Xylo-oligosaccharides from sugarcane	0:35	Xylo-oligosaccharides from sugarcane show prebiotic potential in a dynamic computer-controlled in vitro model of the adult human large intestine.
32208927	6	1	theme	B.	1143:1144	arg1	species					1135:1141	the species	1131:1141	the species B. adolescentis	1131:1157	In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled 'sp.1').
32208927	1	2	theme	human	348:352	arg1	adults					354:359	human adults	348:359	human adults	348:359	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	6	3	theme	unidentified	1166:1177	arg1	sp.1					1198:1201	labelled 'sp.1'	1188:1202	labelled 'sp.1'	1188:1202	In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled 'sp.1').
32208927	6	3	theme	unidentified	1166:1177	arg1	species					1179:1185	an unidentified species	1163:1185	an unidentified species (labelled 'sp.1')	1163:1203	In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled 'sp.1').
32208927	0	4	theme	in	95:96	arg1	model					104:108	a dynamic computer-controlled in vitro model	65:108	a dynamic computer-controlled in vitro model of the adult human large intestine	65:143	Xylo-oligosaccharides from sugarcane show prebiotic potential in a dynamic computer-controlled in vitro model of the adult human large intestine.
32208927	1	5	theme	colon	323:327	arg1	model					310:314	a validated, dynamic, computer-controlled in vitro model	259:314	a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults	259:359	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	7	6	theme	XOS	1257:1259	arg1	effect					1247:1252	the potential prebiotic effect	1223:1252	the potential prebiotic effect of XOS from sugarcane	1223:1274	The results show the potential prebiotic effect of XOS from sugarcane, by its capacity to generate butyrate and increase the health-beneficial bifidobacteria.
32208927	7	7	from	sugarcane	1266:1274	arg1	effect					1247:1252	the potential prebiotic effect	1223:1252	the potential prebiotic effect of XOS from sugarcane	1223:1274	The results show the potential prebiotic effect of XOS from sugarcane, by its capacity to generate butyrate and increase the health-beneficial bifidobacteria.
32208927	5	8	theme	similar	842:848	arg1	important					957:965	important	957:965	important	957:965	XOS showed a similar SCFA production per gram of substrate as the control medium, including butyrate, which is considered to be important for gut health.
32208927	5	8	theme	similar	842:848	arg1	production					855:864	a similar SCFA production	840:864	a similar SCFA production	840:864	XOS showed a similar SCFA production per gram of substrate as the control medium, including butyrate, which is considered to be important for gut health.
32208927	3	9	theme	short-chain	618:628	arg1	SCFA					643:646	SCFA	643:646	SCFA	643:646	The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition.
32208927	3	9	theme	short-chain	618:628	arg1	acids					636:640	short-chain fatty acids	618:640	short-chain fatty acids (SCFA)	618:647	The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition.
32208927	6	10	theme	dose-dependent	1035:1048	arg1	increase					1050:1057	a consistent dose-dependent increase	1022:1057	a consistent dose-dependent increase in abundance	1022:1070	In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled 'sp.1').
32208927	5	11	theme	SCFA	850:853	arg1	important					957:965	important	957:965	important	957:965	XOS showed a similar SCFA production per gram of substrate as the control medium, including butyrate, which is considered to be important for gut health.
32208927	5	11	theme	SCFA	850:853	arg1	production					855:864	a similar SCFA production	840:864	a similar SCFA production	840:864	XOS showed a similar SCFA production per gram of substrate as the control medium, including butyrate, which is considered to be important for gut health.
32208927	0	12	theme	adult	117:121	arg1	intestine					135:143	the adult human large intestine	113:143	the adult human large intestine	113:143	Xylo-oligosaccharides from sugarcane show prebiotic potential in a dynamic computer-controlled in vitro model of the adult human large intestine.
32208927	3	13	theme	fatty	630:634	arg1	SCFA					643:646	SCFA	643:646	SCFA	643:646	The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition.
32208927	3	13	theme	fatty	630:634	arg1	acids					636:640	short-chain fatty acids	618:640	short-chain fatty acids (SCFA)	618:647	The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition.
32208927	4	14	theme	microbiota	734:743	arg1	composition					745:755	microbiota composition	734:755	microbiota composition	734:755	SCFA were analysed using ion chromatography, whereas microbiota composition was analysed using sequencing of the V3-V4 region of the 16S rRNA gene.
32208927	2	15	theme	experiments	377:387	arg1	each					390:393	each	390:393	each	390:393	In two sets of experiments, each with a different microbiota, 3 different doses of XOS were tested at 1.0 g/day, 1.5 g/day and 3.0 g/day.
32208927	2	15	theme	experiments	377:387	arg1	experiments					377:387	experiments	377:387	experiments	377:387	In two sets of experiments, each with a different microbiota, 3 different doses of XOS were tested at 1.0 g/day, 1.5 g/day and 3.0 g/day.
32208927	2	15	theme	experiments	377:387	arg1	sets					369:372	two sets	365:372	two sets of experiments	365:387	In two sets of experiments, each with a different microbiota, 3 different doses of XOS were tested at 1.0 g/day, 1.5 g/day and 3.0 g/day.
32208927	6	16	theme	consistent	1024:1033	arg1	increase					1050:1057	a consistent dose-dependent increase	1022:1057	a consistent dose-dependent increase in abundance	1022:1070	In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled 'sp.1').
32208927	1	17	theme	study	161:165	arg1	aim					150:152	The aim	146:152	The aim of the study	146:165	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	3	18	from	start	548:552	arg1	model					513:517	The in vitro model	500:517	The in vitro model	500:517	The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition.
32208927	3	18	from	start	548:552	arg1	run					523:525	run	523:525	run	523:525	The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition.
32208927	5	19	theme	gut	971:973	arg1	health					975:980	gut health	971:980	gut health	971:980	XOS showed a similar SCFA production per gram of substrate as the control medium, including butyrate, which is considered to be important for gut health.
32208927	6	20	from	increase	1050:1057	arg1	abundance					1062:1070	abundance	1062:1070	abundance	1062:1070	In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled 'sp.1').
32208927	6	21	dep	B.	1143:1144	arg1	adolescentis					1146:1157	adolescentis	1146:1157	adolescentis	1146:1157	In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled 'sp.1').
32208927	2	22	theme	different	402:410	arg1	microbiota					412:421	a different microbiota	400:421	a different microbiota	400:421	In two sets of experiments, each with a different microbiota, 3 different doses of XOS were tested at 1.0 g/day, 1.5 g/day and 3.0 g/day.
32208927	1	23	dep	in	301:302	arg1	vitro					304:308	vitro	304:308	vitro	304:308	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	1	24	dep	validated	261:269	arg1	dynamic					272:278	dynamic	272:278	dynamic	272:278	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	1	24	dep	validated	261:269	arg1	computer-controlled					281:299	computer-controlled	281:299	computer-controlled	281:299	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	1	25	theme	validated	261:269	arg1	model					310:314	a validated, dynamic, computer-controlled in vitro model	259:314	a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults	259:359	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	0	26	dep	in	95:96	arg1	vitro					98:102	vitro	98:102	vitro	98:102	Xylo-oligosaccharides from sugarcane show prebiotic potential in a dynamic computer-controlled in vitro model of the adult human large intestine.
32208927	6	27	theme	labelled	1188:1195	arg1	sp.1					1198:1201	labelled 'sp.1'	1188:1202	labelled 'sp.1'	1188:1202	In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled 'sp.1').
32208927	6	27	theme	labelled	1188:1195	arg1	species					1179:1185	an unidentified species	1163:1185	an unidentified species (labelled 'sp.1')	1163:1203	In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled 'sp.1').
32208927	0	28	theme	large	129:133	arg1	intestine					135:143	the adult human large intestine	113:143	the adult human large intestine	113:143	Xylo-oligosaccharides from sugarcane show prebiotic potential in a dynamic computer-controlled in vitro model of the adult human large intestine.
32208927	3	29	dep	in	504:505	arg1	vitro					507:511	vitro	507:511	vitro	507:511	The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition.
32208927	6	30	theme	experiments	999:1009	arg1	experiments					999:1009	experiments	999:1009	experiments	999:1009	In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled 'sp.1').
32208927	6	30	theme	experiments	999:1009	arg1	sets					991:994	both sets	986:994	both sets of experiments	986:1009	In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled 'sp.1').
32208927	6	31	theme	Bifidobacterium	1095:1109	arg1	time					1077:1080	time	1077:1080	time of the genus Bifidobacterium	1077:1109	In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled 'sp.1').
32208927	0	32	theme	human	123:127	arg1	intestine					135:143	the adult human large intestine	113:143	the adult human large intestine	113:143	Xylo-oligosaccharides from sugarcane show prebiotic potential in a dynamic computer-controlled in vitro model of the adult human large intestine.
32208927	4	33	theme	rRNA	818:821	arg1	gene					823:826	the 16S rRNA gene	810:826	the 16S rRNA gene	810:826	SCFA were analysed using ion chromatography, whereas microbiota composition was analysed using sequencing of the V3-V4 region of the 16S rRNA gene.
32208927	7	34	theme	prebiotic	1237:1245	arg1	effect					1247:1252	the potential prebiotic effect	1223:1252	the potential prebiotic effect of XOS from sugarcane	1223:1274	The results show the potential prebiotic effect of XOS from sugarcane, by its capacity to generate butyrate and increase the health-beneficial bifidobacteria.
32208927	1	35	theme	prebiotic	190:198	arg1	potential					200:208	the prebiotic potential	186:208	the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane	186:254	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	2	36	theme	different	426:434	arg1	doses					436:440	3 different doses	424:440	3 different doses of XOS	424:447	In two sets of experiments, each with a different microbiota, 3 different doses of XOS were tested at 1.0 g/day, 1.5 g/day and 3.0 g/day.
32208927	4	37	theme	gene	823:826	arg1	region					800:805	the V3-V4 region	790:805	the V3-V4 region of the 16S rRNA gene	790:826	SCFA were analysed using ion chromatography, whereas microbiota composition was analysed using sequencing of the V3-V4 region of the 16S rRNA gene.
32208927	4	38	theme	ion	706:708	arg1	chromatography					710:723	ion chromatography	706:723	ion chromatography	706:723	SCFA were analysed using ion chromatography, whereas microbiota composition was analysed using sequencing of the V3-V4 region of the 16S rRNA gene.
32208927	0	39	theme	prebiotic	42:50	arg1	potential					52:60	prebiotic potential	42:60	prebiotic potential	42:60	Xylo-oligosaccharides from sugarcane show prebiotic potential in a dynamic computer-controlled in vitro model of the adult human large intestine.
32208927	3	40	theme	microbiota	657:666	arg1	composition					668:678	gut microbiota composition	653:678	gut microbiota composition	653:678	The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition.
32208927	0	41	theme	intestine	135:143	arg1	model					104:108	a dynamic computer-controlled in vitro model	65:108	a dynamic computer-controlled in vitro model of the adult human large intestine	65:143	Xylo-oligosaccharides from sugarcane show prebiotic potential in a dynamic computer-controlled in vitro model of the adult human large intestine.
32208927	5	42	theme	control	895:901	arg1	medium					903:908	the control medium	891:908	the control medium	891:908	XOS showed a similar SCFA production per gram of substrate as the control medium, including butyrate, which is considered to be important for gut health.
32208927	1	43	from	potential	200:208	arg1	sugarcane					246:254	sugarcane	246:254	sugarcane	246:254	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	1	44	theme	in	301:302	arg1	model					310:314	a validated, dynamic, computer-controlled in vitro model	259:314	a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults	259:359	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	4	45	theme	V3-V4	794:798	arg1	region					800:805	the V3-V4 region	790:805	the V3-V4 region of the 16S rRNA gene	790:826	SCFA were analysed using ion chromatography, whereas microbiota composition was analysed using sequencing of the V3-V4 region of the 16S rRNA gene.
32208927	2	46	theme	XOS	445:447	arg1	doses					436:440	3 different doses	424:440	3 different doses of XOS	424:447	In two sets of experiments, each with a different microbiota, 3 different doses of XOS were tested at 1.0 g/day, 1.5 g/day and 3.0 g/day.
32208927	3	47	theme	in	504:505	arg1	model					513:517	The in vitro model	500:517	The in vitro model	500:517	The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition.
32208927	3	47	theme	in	504:505	arg1	run					523:525	run	523:525	run	523:525	The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition.
32208927	1	48	from	sugarcane	246:254	arg1	XOS					236:238	XOS	236:238	XOS	236:238	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	1	48	from	sugarcane	246:254	arg1	xylo-oligosaccharides					213:233	xylo-oligosaccharides	213:233	xylo-oligosaccharides (XOS) from sugarcane	213:254	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	1	48	from	sugarcane	246:254	arg1	potential					200:208	the prebiotic potential	186:208	the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane	186:254	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	4	49	theme	16S	814:816	arg1	rRNA					818:821	16S rRNA	814:821	the 16S rRNA gene	810:826	SCFA were analysed using ion chromatography, whereas microbiota composition was analysed using sequencing of the V3-V4 region of the 16S rRNA gene.
32208927	3	50	theme	every	571:575	arg1	samples					582:588	subsequently every 24 h samples	558:588	subsequently every 24 h samples	558:588	The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition.
32208927	3	51	theme	gut	653:655	arg1	composition					668:678	gut microbiota composition	653:678	gut microbiota composition	653:678	The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition.
32208927	3	52	theme	24 h	577:580	arg1	samples					582:588	subsequently every 24 h samples	558:588	subsequently every 24 h samples	558:588	The in vitro model was run for 72 h, and at the start and subsequently every 24 h samples were taken and analysed for short-chain fatty acids (SCFA) and gut microbiota composition.
32208927	6	53	theme	genus	1089:1093	arg1	Bifidobacterium					1095:1109	the genus Bifidobacterium	1085:1109	the genus Bifidobacterium	1085:1109	In both sets of experiments XOS showed a consistent dose-dependent increase in abundance over time of the genus Bifidobacterium, and within that of the species B. adolescentis and an unidentified species (labelled 'sp.1').
32208927	7	54	theme	potential	1227:1235	arg1	effect					1247:1252	the potential prebiotic effect	1223:1252	the potential prebiotic effect of XOS from sugarcane	1223:1274	The results show the potential prebiotic effect of XOS from sugarcane, by its capacity to generate butyrate and increase the health-beneficial bifidobacteria.
32208927	1	55	theme	xylo-oligosaccharides	213:233	arg1	potential					200:208	the prebiotic potential	186:208	the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane	186:254	The aim of the study was to investigate the prebiotic potential of xylo-oligosaccharides (XOS) from sugarcane in a validated, dynamic, computer-controlled in vitro model of the colon (TIM-2) simulating human adults.
32208927	4	56	theme	region	800:805	arg1	sequencing					776:785	sequencing	776:785	sequencing of the V3-V4 region of the 16S rRNA gene	776:826	SCFA were analysed using ion chromatography, whereas microbiota composition was analysed using sequencing of the V3-V4 region of the 16S rRNA gene.
32208927	0	57	theme	computer-controlled	75:93	arg1	model					104:108	a dynamic computer-controlled in vitro model	65:108	a dynamic computer-controlled in vitro model of the adult human large intestine	65:143	Xylo-oligosaccharides from sugarcane show prebiotic potential in a dynamic computer-controlled in vitro model of the adult human large intestine.
32208927	7	58	theme	health-beneficial	1331:1347	arg1	bifidobacteria					1349:1362	the health-beneficial bifidobacteria	1327:1362	the health-beneficial bifidobacteria	1327:1362	The results show the potential prebiotic effect of XOS from sugarcane, by its capacity to generate butyrate and increase the health-beneficial bifidobacteria.
32208927	5	59	theme	substrate	878:886	arg1	gram					870:873	gram	870:873	gram of substrate as the control medium	870:908	XOS showed a similar SCFA production per gram of substrate as the control medium, including butyrate, which is considered to be important for gut health.
32208927	0	60	theme	dynamic	67:73	arg1	model					104:108	a dynamic computer-controlled in vitro model	65:108	a dynamic computer-controlled in vitro model of the adult human large intestine	65:143	Xylo-oligosaccharides from sugarcane show prebiotic potential in a dynamic computer-controlled in vitro model of the adult human large intestine.
33383077	0	0	theme	formate	73:79	arg1	application					89:99	its application	85:99	its application as a reducing agent	85:119	Influence of drying methods on the structure and properties of cellulose formate and its application as a reducing agent.
33383077	0	0	theme	formate	73:79	arg1	properties					49:58	properties	49:58	properties	49:58	Influence of drying methods on the structure and properties of cellulose formate and its application as a reducing agent.
33383077	0	0	theme	formate	73:79	arg1	structure					35:43	structure	35:43	structure	35:43	Influence of drying methods on the structure and properties of cellulose formate and its application as a reducing agent.
33383077	5	1	theme	original	695:702	arg1	structure					704:712	its original structure	691:712	its original structure	691:712	The freeze-dried CF sample maintained its original structure, while the air-dried and oven-dried CF samples with amorphous structure showed the aggregation state.
33383077	7	2	theme	20-50 nm	1033:1040	arg1	diameter					1021:1028	the diameter	1017:1028	the diameter of 20-50 nm on the surface of CF samples	1017:1069	SEM and TEM images exhibited a large number of Ag nanoparticles with the diameter of 20-50 nm on the surface of CF samples.
33383077	7	3	theme	TEM	956:958	arg1	images					960:965	SEM and TEM images	948:965	SEM and TEM images	948:965	SEM and TEM images exhibited a large number of Ag nanoparticles with the diameter of 20-50 nm on the surface of CF samples.
33383077	8	4	theme	great	1245:1249	arg1	applications					1261:1272	great potential applications	1245:1272	great potential applications	1245:1272	As expected, the fabricated CF/Ag composites showed strong antibacterial activity against both Escherichia coli and Bacillus subtilis, and thus the prepared composites have great potential applications in antibacterial daily necessities and medical supplies.
33383077	4	5	theme	CF	502:503	arg1	samples					505:511	the CF samples	498:511	the CF samples as special cellulose nanofibrils with cellulose II crystal form and fibrous structure	498:597	Results showed that the CF samples as special cellulose nanofibrils with cellulose II crystal form and fibrous structure were sensitive to drying temperature and drying time.
33383077	4	5	theme	CF	502:503	arg1	sensitive					604:612	sensitive	604:612	sensitive	604:612	Results showed that the CF samples as special cellulose nanofibrils with cellulose II crystal form and fibrous structure were sensitive to drying temperature and drying time.
33383077	0	6	theme	cellulose	63:71	arg1	formate					73:79	cellulose formate	63:79	cellulose formate	63:79	Influence of drying methods on the structure and properties of cellulose formate and its application as a reducing agent.
33383077	6	7	used	used	922:925	arg2	CF					915:916	the never dried CF	899:916	the never dried CF	899:916	Furthermore, the CF/Ag composites were prepared using silver mirror reaction where the never dried CF was used as a reducing agent.
33383077	6	7	used	used	922:925	arg2	agent					941:945	a reducing agent	930:945	a reducing agent	930:945	Furthermore, the CF/Ag composites were prepared using silver mirror reaction where the never dried CF was used as a reducing agent.
33383077	4	8	theme	drying	617:622	arg1	temperature					624:634	drying temperature	617:634	drying temperature	617:634	Results showed that the CF samples as special cellulose nanofibrils with cellulose II crystal form and fibrous structure were sensitive to drying temperature and drying time.
33383077	7	9	theme	samples	1063:1069	arg1	surface					1049:1055	the surface	1045:1055	the surface of CF samples	1045:1069	SEM and TEM images exhibited a large number of Ag nanoparticles with the diameter of 20-50 nm on the surface of CF samples.
33383077	0	10	from	Influence	0:8	arg1	application					89:99	its application	85:99	its application as a reducing agent	85:119	Influence of drying methods on the structure and properties of cellulose formate and its application as a reducing agent.
33383077	0	10	from	Influence	0:8	arg1	properties					49:58	properties	49:58	properties	49:58	Influence of drying methods on the structure and properties of cellulose formate and its application as a reducing agent.
33383077	0	10	from	Influence	0:8	arg1	structure					35:43	structure	35:43	structure	35:43	Influence of drying methods on the structure and properties of cellulose formate and its application as a reducing agent.
33383077	1	11	theme	formic	237:242	arg1	FA					250:251	FA	250:251	FA	250:251	Cellulose formate (CF) with surface formyl groups can be prepared through the esterification between cellulose and formic acid (FA).
33383077	1	11	theme	formic	237:242	arg1	acid					244:247	formic acid	237:247	formic acid (FA)	237:252	Cellulose formate (CF) with surface formyl groups can be prepared through the esterification between cellulose and formic acid (FA).
33383077	5	12	theme	freeze-dried	657:668	arg1	sample					673:678	The freeze-dried CF sample	653:678	The freeze-dried CF sample	653:678	The freeze-dried CF sample maintained its original structure, while the air-dried and oven-dried CF samples with amorphous structure showed the aggregation state.
33383077	6	13	theme	CF/Ag	833:837	arg1	composites					839:848	the CF/Ag composites	829:848	the CF/Ag composites	829:848	Furthermore, the CF/Ag composites were prepared using silver mirror reaction where the never dried CF was used as a reducing agent.
33383077	1	14	with	formate	132:138	arg1	groups					165:170	surface formyl groups	150:170	surface formyl groups	150:170	Cellulose formate (CF) with surface formyl groups can be prepared through the esterification between cellulose and formic acid (FA).
33383077	8	15	theme	potential	1251:1259	arg1	applications					1261:1272	great potential applications	1245:1272	great potential applications	1245:1272	As expected, the fabricated CF/Ag composites showed strong antibacterial activity against both Escherichia coli and Bacillus subtilis, and thus the prepared composites have great potential applications in antibacterial daily necessities and medical supplies.
33383077	5	16	theme	CF	670:671	arg1	sample					673:678	The freeze-dried CF sample	653:678	The freeze-dried CF sample	653:678	The freeze-dried CF sample maintained its original structure, while the air-dried and oven-dried CF samples with amorphous structure showed the aggregation state.
33383077	5	17	theme	amorphous	766:774	arg1	structure					776:784	amorphous structure	766:784	amorphous structure	766:784	The freeze-dried CF sample maintained its original structure, while the air-dried and oven-dried CF samples with amorphous structure showed the aggregation state.
33383077	4	18	theme	cellulose	551:559	arg1	form					572:575	cellulose II crystal form	551:575	cellulose II crystal form	551:575	Results showed that the CF samples as special cellulose nanofibrils with cellulose II crystal form and fibrous structure were sensitive to drying temperature and drying time.
33383077	3	19	theme	resultant	447:455	arg1	CF					457:458	the resultant CF	443:458	the resultant CF	443:458	In this work, the effect of four drying methods on the structure and properties of the resultant CF was investigated.
33383077	4	20	theme	fibrous	581:587	arg1	structure					589:597	fibrous structure	581:597	fibrous structure	581:597	Results showed that the CF samples as special cellulose nanofibrils with cellulose II crystal form and fibrous structure were sensitive to drying temperature and drying time.
33383077	8	21	theme	strong	1124:1129	arg1	activity					1145:1152	strong antibacterial activity	1124:1152	strong antibacterial activity against both Escherichia coli and Bacillus subtilis	1124:1204	As expected, the fabricated CF/Ag composites showed strong antibacterial activity against both Escherichia coli and Bacillus subtilis, and thus the prepared composites have great potential applications in antibacterial daily necessities and medical supplies.
33383077	3	22	theme	CF	457:458	arg1	properties					429:438	properties	429:438	properties	429:438	In this work, the effect of four drying methods on the structure and properties of the resultant CF was investigated.
33383077	3	22	theme	CF	457:458	arg1	structure					415:423	structure	415:423	structure	415:423	In this work, the effect of four drying methods on the structure and properties of the resultant CF was investigated.
33383077	5	23	theme	aggregation	797:807	arg1	state					809:813	the aggregation state	793:813	the aggregation state	793:813	The freeze-dried CF sample maintained its original structure, while the air-dried and oven-dried CF samples with amorphous structure showed the aggregation state.
33383077	7	24	theme	Ag	995:996	arg1	nanoparticles					998:1010	Ag nanoparticles	995:1010	Ag nanoparticles	995:1010	SEM and TEM images exhibited a large number of Ag nanoparticles with the diameter of 20-50 nm on the surface of CF samples.
33383077	2	25	theme	CF	273:274	arg1	properties					259:268	The properties	255:268	The properties of CF	255:274	The properties of CF are sensitive to temperature, which is of great importance for its end application.
33383077	2	25	theme	CF	273:274	arg1	sensitive					280:288	sensitive	280:288	sensitive	280:288	The properties of CF are sensitive to temperature, which is of great importance for its end application.
33383077	1	26	theme	surface	150:156	arg1	groups					165:170	surface formyl groups	150:170	surface formyl groups	150:170	Cellulose formate (CF) with surface formyl groups can be prepared through the esterification between cellulose and formic acid (FA).
33383077	5	27	theme	oven-dried	739:748	arg1	samples					753:759	the air-dried and oven-dried CF samples	721:759	the air-dried and oven-dried CF samples with amorphous structure	721:784	The freeze-dried CF sample maintained its original structure, while the air-dried and oven-dried CF samples with amorphous structure showed the aggregation state.
33383077	7	28	theme	nanoparticles	998:1010	arg1	number					985:990	a large number	977:990	a large number of Ag nanoparticles	977:1010	SEM and TEM images exhibited a large number of Ag nanoparticles with the diameter of 20-50 nm on the surface of CF samples.
33383077	5	29	with	samples	753:759	arg1	structure					776:784	amorphous structure	766:784	amorphous structure	766:784	The freeze-dried CF sample maintained its original structure, while the air-dried and oven-dried CF samples with amorphous structure showed the aggregation state.
33383077	2	30	theme	great	318:322	arg1	importance					324:333	great importance	318:333	great importance	318:333	The properties of CF are sensitive to temperature, which is of great importance for its end application.
33383077	0	31	theme	methods	20:26	arg1	Influence					0:8	Influence	0:8	Influence of drying methods on the structure and properties of cellulose formate and its application as a reducing agent.	0:120	Influence of drying methods on the structure and properties of cellulose formate and its application as a reducing agent.
33383077	6	32	theme	dried	909:913	arg1	agent					941:945	a reducing agent	930:945	a reducing agent	930:945	Furthermore, the CF/Ag composites were prepared using silver mirror reaction where the never dried CF was used as a reducing agent.
33383077	6	32	theme	dried	909:913	arg1	CF					915:916	the never dried CF	899:916	the never dried CF	899:916	Furthermore, the CF/Ag composites were prepared using silver mirror reaction where the never dried CF was used as a reducing agent.
33383077	0	33	theme	reducing	106:113	arg1	agent					115:119	a reducing agent	104:119	a reducing agent	104:119	Influence of drying methods on the structure and properties of cellulose formate and its application as a reducing agent.
33383077	8	34	theme	CF/Ag	1100:1104	arg1	composites					1106:1115	the fabricated CF/Ag composites	1085:1115	the fabricated CF/Ag composites	1085:1115	As expected, the fabricated CF/Ag composites showed strong antibacterial activity against both Escherichia coli and Bacillus subtilis, and thus the prepared composites have great potential applications in antibacterial daily necessities and medical supplies.
33383077	8	35	theme	medical	1313:1319	arg1	supplies					1321:1328	medical supplies	1313:1328	medical supplies	1313:1328	As expected, the fabricated CF/Ag composites showed strong antibacterial activity against both Escherichia coli and Bacillus subtilis, and thus the prepared composites have great potential applications in antibacterial daily necessities and medical supplies.
33383077	0	36	theme	drying	13:18	arg1	methods					20:26	drying methods	13:26	drying methods	13:26	Influence of drying methods on the structure and properties of cellulose formate and its application as a reducing agent.
33383077	8	37	theme	antibacterial	1277:1289	arg1	necessities					1297:1307	antibacterial daily necessities	1277:1307	antibacterial daily necessities	1277:1307	As expected, the fabricated CF/Ag composites showed strong antibacterial activity against both Escherichia coli and Bacillus subtilis, and thus the prepared composites have great potential applications in antibacterial daily necessities and medical supplies.
33383077	5	38	theme	CF	750:751	arg1	samples					753:759	the air-dried and oven-dried CF samples	721:759	the air-dried and oven-dried CF samples with amorphous structure	721:784	The freeze-dried CF sample maintained its original structure, while the air-dried and oven-dried CF samples with amorphous structure showed the aggregation state.
33383077	3	39	theme	drying	393:398	arg1	methods					400:406	four drying methods	388:406	four drying methods	388:406	In this work, the effect of four drying methods on the structure and properties of the resultant CF was investigated.
33383077	1	40	theme	formyl	158:163	arg1	groups					165:170	surface formyl groups	150:170	surface formyl groups	150:170	Cellulose formate (CF) with surface formyl groups can be prepared through the esterification between cellulose and formic acid (FA).
33383077	7	41	theme	CF	1060:1061	arg1	samples					1063:1069	CF samples	1060:1069	CF samples	1060:1069	SEM and TEM images exhibited a large number of Ag nanoparticles with the diameter of 20-50 nm on the surface of CF samples.
33383077	7	42	from	diameter	1021:1028	arg1	surface					1049:1055	the surface	1045:1055	the surface of CF samples	1045:1069	SEM and TEM images exhibited a large number of Ag nanoparticles with the diameter of 20-50 nm on the surface of CF samples.
33383077	7	43	theme	large	979:983	arg1	number					985:990	a large number	977:990	a large number of Ag nanoparticles	977:1010	SEM and TEM images exhibited a large number of Ag nanoparticles with the diameter of 20-50 nm on the surface of CF samples.
33383077	0	44	dep	structure	35:43	arg1	the					31:33	the	31:33	the	31:33	Influence of drying methods on the structure and properties of cellulose formate and its application as a reducing agent.
33383077	3	45	from	effect	378:383	arg1	properties					429:438	properties	429:438	properties	429:438	In this work, the effect of four drying methods on the structure and properties of the resultant CF was investigated.
33383077	3	45	from	effect	378:383	arg1	structure					415:423	structure	415:423	structure	415:423	In this work, the effect of four drying methods on the structure and properties of the resultant CF was investigated.
33383077	2	46	theme	end	343:345	arg1	application					347:357	its end application	339:357	its end application	339:357	The properties of CF are sensitive to temperature, which is of great importance for its end application.
33383077	8	47	theme	antibacterial	1131:1143	arg1	activity					1145:1152	strong antibacterial activity	1124:1152	strong antibacterial activity against both Escherichia coli and Bacillus subtilis	1124:1204	As expected, the fabricated CF/Ag composites showed strong antibacterial activity against both Escherichia coli and Bacillus subtilis, and thus the prepared composites have great potential applications in antibacterial daily necessities and medical supplies.
33383077	6	48	dep	reaction	884:891	arg1	mirror					877:882	mirror	877:882	mirror	877:882	Furthermore, the CF/Ag composites were prepared using silver mirror reaction where the never dried CF was used as a reducing agent.
33383077	7	49	theme	SEM	948:950	arg1	images					960:965	SEM and TEM images	948:965	SEM and TEM images	948:965	SEM and TEM images exhibited a large number of Ag nanoparticles with the diameter of 20-50 nm on the surface of CF samples.
33383077	4	50	theme	drying	640:645	arg1	time					647:650	drying time	640:650	drying time	640:650	Results showed that the CF samples as special cellulose nanofibrils with cellulose II crystal form and fibrous structure were sensitive to drying temperature and drying time.
33383077	5	51	theme	air-dried	725:733	arg1	samples					753:759	the air-dried and oven-dried CF samples	721:759	the air-dried and oven-dried CF samples with amorphous structure	721:784	The freeze-dried CF sample maintained its original structure, while the air-dried and oven-dried CF samples with amorphous structure showed the aggregation state.
33383077	8	52	contain	have	1240:1243	arg1	composites					1229:1238	the prepared composites	1216:1238	the prepared composites	1216:1238	As expected, the fabricated CF/Ag composites showed strong antibacterial activity against both Escherichia coli and Bacillus subtilis, and thus the prepared composites have great potential applications in antibacterial daily necessities and medical supplies.
33383077	8	52	contain	have	1240:1243	arg2	applications					1261:1272	great potential applications	1245:1272	great potential applications	1245:1272	As expected, the fabricated CF/Ag composites showed strong antibacterial activity against both Escherichia coli and Bacillus subtilis, and thus the prepared composites have great potential applications in antibacterial daily necessities and medical supplies.
33383077	6	53	theme	silver	870:875	arg1	reaction					884:891	silver mirror reaction	870:891	silver mirror reaction where the never dried CF was used as a reducing agent	870:945	Furthermore, the CF/Ag composites were prepared using silver mirror reaction where the never dried CF was used as a reducing agent.
33383077	8	54	theme	daily	1291:1295	arg1	necessities					1297:1307	antibacterial daily necessities	1277:1307	antibacterial daily necessities	1277:1307	As expected, the fabricated CF/Ag composites showed strong antibacterial activity against both Escherichia coli and Bacillus subtilis, and thus the prepared composites have great potential applications in antibacterial daily necessities and medical supplies.
33383077	4	55	with	nanofibrils	534:544	arg1	form					572:575	cellulose II crystal form	551:575	cellulose II crystal form	551:575	Results showed that the CF samples as special cellulose nanofibrils with cellulose II crystal form and fibrous structure were sensitive to drying temperature and drying time.
33383077	4	55	with	nanofibrils	534:544	arg1	structure					589:597	fibrous structure	581:597	fibrous structure	581:597	Results showed that the CF samples as special cellulose nanofibrils with cellulose II crystal form and fibrous structure were sensitive to drying temperature and drying time.
33383077	3	56	theme	methods	400:406	arg1	effect					378:383	the effect	374:383	the effect of four drying methods on the structure and properties of the resultant CF	374:458	In this work, the effect of four drying methods on the structure and properties of the resultant CF was investigated.
33383077	4	57	theme	cellulose	524:532	arg1	nanofibrils					534:544	special cellulose nanofibrils	516:544	special cellulose nanofibrils with cellulose II crystal form and fibrous structure	516:597	Results showed that the CF samples as special cellulose nanofibrils with cellulose II crystal form and fibrous structure were sensitive to drying temperature and drying time.
33383077	3	58	dep	structure	415:423	arg1	the					411:413	the	411:413	the	411:413	In this work, the effect of four drying methods on the structure and properties of the resultant CF was investigated.
33383077	4	59	theme	special	516:522	arg1	nanofibrils					534:544	special cellulose nanofibrils	516:544	special cellulose nanofibrils with cellulose II crystal form and fibrous structure	516:597	Results showed that the CF samples as special cellulose nanofibrils with cellulose II crystal form and fibrous structure were sensitive to drying temperature and drying time.
33383077	4	60	theme	crystal	564:570	arg1	form					572:575	cellulose II crystal form	551:575	cellulose II crystal form	551:575	Results showed that the CF samples as special cellulose nanofibrils with cellulose II crystal form and fibrous structure were sensitive to drying temperature and drying time.
33383077	1	61	theme	Cellulose	122:130	arg1	formate					132:138	Cellulose formate	122:138	Cellulose formate (CF) with surface formyl groups	122:170	Cellulose formate (CF) with surface formyl groups can be prepared through the esterification between cellulose and formic acid (FA).
33383077	1	61	theme	Cellulose	122:130	arg1	CF					141:142	CF	141:142	CF	141:142	Cellulose formate (CF) with surface formyl groups can be prepared through the esterification between cellulose and formic acid (FA).
33383077	8	62	theme	fabricated	1089:1098	arg1	composites					1106:1115	the fabricated CF/Ag composites	1085:1115	the fabricated CF/Ag composites	1085:1115	As expected, the fabricated CF/Ag composites showed strong antibacterial activity against both Escherichia coli and Bacillus subtilis, and thus the prepared composites have great potential applications in antibacterial daily necessities and medical supplies.
33383077	8	63	theme	prepared	1220:1227	arg1	composites					1229:1238	the prepared composites	1216:1238	the prepared composites	1216:1238	As expected, the fabricated CF/Ag composites showed strong antibacterial activity against both Escherichia coli and Bacillus subtilis, and thus the prepared composites have great potential applications in antibacterial daily necessities and medical supplies.
33383077	6	64	theme	reducing	932:939	arg1	agent					941:945	a reducing agent	930:945	a reducing agent	930:945	Furthermore, the CF/Ag composites were prepared using silver mirror reaction where the never dried CF was used as a reducing agent.
33383077	6	64	theme	reducing	932:939	arg1	CF					915:916	the never dried CF	899:916	the never dried CF	899:916	Furthermore, the CF/Ag composites were prepared using silver mirror reaction where the never dried CF was used as a reducing agent.
32590279	7	0	theme	CR	1183:1184	arg1	dose					1186:1189	CR dose	1183:1189	CR dose of 100 mg/L	1183:1201	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	6	1	theme	zeta	860:863	arg1	analysis					875:882	zeta potential analysis	860:882	zeta potential analysis	860:882	According to scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectrometer, and zeta potential analysis, its adsorption on CS-VTM can be attributed to electrostatic attraction and hydrogen bonds.
32590279	7	2	dep	μM-1	1129:1132	arg1	capacity					1158:1165	equilibrium adsorption capacity	1135:1165	equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L	1135:1201	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	2	3	theme	potent	335:340	arg1	involvement					342:352	the potent involvement	331:352	the potent involvement of chemisorption	331:369	The interaction between CS-VTM and Congo red (CR) dye conformed to a pseudo-second-order model to support the potent involvement of chemisorption.
32590279	8	4	theme	environmentally	1254:1268	arg1	friendly					1270:1277	a promising and environmentally friendly	1238:1277	a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date	1238:1396	Overall, the CS-VTM proved to be a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date.
32590279	8	4	theme	environmentally	1254:1268	arg1	CS-VTM					1218:1223	the CS-VTM	1214:1223	the CS-VTM	1214:1223	Overall, the CS-VTM proved to be a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date.
32590279	7	5	theme	large	1085:1089	arg1	coefficient					1101:1111	significantly large partition coefficient	1071:1111	significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L)	1071:1202	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	4	6	theme	65 °C	631:635	arg1	temperatures					615:626	temperatures	615:626	temperatures of 65 °C	615:635	Approximately 99.1% of CR (100 mg/L) was adsorbed at a CS-VTM dose of 2.0 g/L or above, while such a reaction was favored at temperatures of 65 °C and pH of 6.0.
32590279	4	6	theme	65 °C	631:635	arg1	pH					641:642	pH	641:642	pH of 6.0	641:649	Approximately 99.1% of CR (100 mg/L) was adsorbed at a CS-VTM dose of 2.0 g/L or above, while such a reaction was favored at temperatures of 65 °C and pH of 6.0.
32590279	6	7	theme	electrostatic	931:943	arg1	attraction					945:954	electrostatic attraction	931:954	electrostatic attraction	931:954	According to scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectrometer, and zeta potential analysis, its adsorption on CS-VTM can be attributed to electrostatic attraction and hydrogen bonds.
32590279	7	8	theme	62.2 mg/g	1170:1178	arg1	capacity					1158:1165	equilibrium adsorption capacity	1135:1165	equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L	1135:1201	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	4	9	theme	6.0	647:649	arg1	temperatures					615:626	temperatures	615:626	temperatures of 65 °C	615:635	Approximately 99.1% of CR (100 mg/L) was adsorbed at a CS-VTM dose of 2.0 g/L or above, while such a reaction was favored at temperatures of 65 °C and pH of 6.0.
32590279	4	9	theme	6.0	647:649	arg1	pH					641:642	pH	641:642	pH of 6.0	641:649	Approximately 99.1% of CR (100 mg/L) was adsorbed at a CS-VTM dose of 2.0 g/L or above, while such a reaction was favored at temperatures of 65 °C and pH of 6.0.
32590279	7	10	theme	CR	1052:1053	arg1	removal					1041:1047	removal	1041:1047	removal of CR	1041:1053	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	2	11	dep	CS-VTM	249:254	arg1	dye					275:277	dye	275:277	dye	275:277	The interaction between CS-VTM and Congo red (CR) dye conformed to a pseudo-second-order model to support the potent involvement of chemisorption.
32590279	4	12	theme	CS-VTM	545:550	arg1	dose					552:555	a CS-VTM dose	543:555	a CS-VTM dose of 2.0 g/L	543:566	Approximately 99.1% of CR (100 mg/L) was adsorbed at a CS-VTM dose of 2.0 g/L or above, while such a reaction was favored at temperatures of 65 °C and pH of 6.0.
32590279	8	13	theme	efficient	1304:1312	arg1	removal					1328:1334	the highly efficient and effective removal	1293:1334	the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date	1293:1396	Overall, the CS-VTM proved to be a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date.
32590279	2	14	theme	pseudo-second-order	294:312	arg1	model					314:318	a pseudo-second-order model	292:318	a pseudo-second-order model to support the potent involvement of chemisorption	292:369	The interaction between CS-VTM and Congo red (CR) dye conformed to a pseudo-second-order model to support the potent involvement of chemisorption.
32590279	0	15	theme	novel	2:6	arg1	chitosan-vanadium-titanium-magnetite					8:43	A novel chitosan-vanadium-titanium-magnetite	0:43	A novel chitosan-vanadium-titanium-magnetite	0:43	A novel chitosan-vanadium-titanium-magnetite composite as a superior adsorbent for organic dyes in wastewater.
32590279	3	16	from	effects	376:382	arg1	adsorption					454:463	adsorption	454:463	adsorption of CR	454:469	The effects of adsorbent dosage, reaction temperature, and initial solution pH on adsorption of CR were investigated.
32590279	7	17	theme	equilibrium	1135:1145	arg1	capacity					1158:1165	equilibrium adsorption capacity	1135:1165	equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L	1135:1201	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	3	18	theme	reaction	405:412	arg1	temperature					414:424	reaction temperature	405:424	reaction temperature	405:424	The effects of adsorbent dosage, reaction temperature, and initial solution pH on adsorption of CR were investigated.
32590279	7	19	theme	adsorption	1147:1156	arg1	capacity					1158:1165	equilibrium adsorption capacity	1135:1165	equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L	1135:1201	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	8	20	theme	effective	1318:1326	arg1	removal					1328:1334	the highly efficient and effective removal	1293:1334	the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date	1293:1396	Overall, the CS-VTM proved to be a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date.
32590279	3	21	theme	temperature	414:424	arg1	effects					376:382	The effects	372:382	The effects of adsorbent dosage, reaction temperature, and initial solution pH on adsorption of CR	372:469	The effects of adsorbent dosage, reaction temperature, and initial solution pH on adsorption of CR were investigated.
32590279	7	22	theme	μM-1	1129:1132	arg1	coefficient					1101:1111	significantly large partition coefficient	1071:1111	significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L)	1071:1202	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	5	23	dep	proceeded	692:700	arg1	ΔG < 0					717:722	ΔG < 0	717:722	ΔG < 0	717:722	Thermodynamically, the adsorption of CR proceeded spontaneously (ΔG < 0) above 35 °C.
32590279	8	24	theme	organic	1339:1345	arg1	dyes					1347:1350	organic dyes	1339:1350	organic dyes	1339:1350	Overall, the CS-VTM proved to be a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date.
32590279	3	25	theme	pH	448:449	arg1	effects					376:382	The effects	372:382	The effects of adsorbent dosage, reaction temperature, and initial solution pH on adsorption of CR	372:469	The effects of adsorbent dosage, reaction temperature, and initial solution pH on adsorption of CR were investigated.
32590279	7	26	from	capacity	1158:1165	arg1	dose					1186:1189	CR dose	1183:1189	CR dose of 100 mg/L	1183:1201	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	8	27	theme	adsorbent	1279:1287	arg1	friendly					1270:1277	a promising and environmentally friendly	1238:1277	a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date	1238:1396	Overall, the CS-VTM proved to be a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date.
32590279	8	27	theme	adsorbent	1279:1287	arg1	CS-VTM					1218:1223	the CS-VTM	1214:1223	the CS-VTM	1214:1223	Overall, the CS-VTM proved to be a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date.
32590279	3	28	theme	dosage	397:402	arg1	effects					376:382	The effects	372:382	The effects of adsorbent dosage, reaction temperature, and initial solution pH on adsorption of CR	372:469	The effects of adsorbent dosage, reaction temperature, and initial solution pH on adsorption of CR were investigated.
32590279	7	29	theme	superior	1006:1013	arg1	performance					1026:1036	superior adsorption performance	1006:1036	superior adsorption performance	1006:1036	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	0	30	from	dyes	91:94	arg1	wastewater					99:108	wastewater	99:108	wastewater	99:108	A novel chitosan-vanadium-titanium-magnetite composite as a superior adsorbent for organic dyes in wastewater.
32590279	2	31	theme	chemisorption	357:369	arg1	involvement					342:352	the potent involvement	331:352	the potent involvement of chemisorption	331:369	The interaction between CS-VTM and Congo red (CR) dye conformed to a pseudo-second-order model to support the potent involvement of chemisorption.
32590279	3	32	theme	initial	431:437	arg1	pH					448:449	initial solution pH	431:449	initial solution pH	431:449	The effects of adsorbent dosage, reaction temperature, and initial solution pH on adsorption of CR were investigated.
32590279	7	33	theme	108.3 mg g-1	1116:1127	arg1	μM-1					1129:1132	108.3 mg g-1 μM-1	1116:1132	108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L)	1116:1202	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	7	34	theme	adsorption	1015:1024	arg1	performance					1026:1036	superior adsorption performance	1006:1036	superior adsorption performance	1006:1036	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	6	35	theme	photoelectron	787:799	arg1	spectroscopy					801:812	X-ray photoelectron spectroscopy	781:812	X-ray photoelectron spectroscopy	781:812	According to scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectrometer, and zeta potential analysis, its adsorption on CS-VTM can be attributed to electrostatic attraction and hydrogen bonds.
32590279	8	36	theme	dyes	1347:1350	arg1	removal					1328:1334	the highly efficient and effective removal	1293:1334	the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date	1293:1396	Overall, the CS-VTM proved to be a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date.
32590279	8	37	theme	promising	1240:1248	arg1	friendly					1270:1277	a promising and environmentally friendly	1238:1277	a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date	1238:1396	Overall, the CS-VTM proved to be a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date.
32590279	8	37	theme	promising	1240:1248	arg1	CS-VTM					1218:1223	the CS-VTM	1214:1223	the CS-VTM	1214:1223	Overall, the CS-VTM proved to be a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date.
32590279	3	38	theme	solution	439:446	arg1	pH					448:449	initial solution pH	431:449	initial solution pH	431:449	The effects of adsorbent dosage, reaction temperature, and initial solution pH on adsorption of CR were investigated.
32590279	7	39	theme	partition	1091:1099	arg1	coefficient					1101:1111	significantly large partition coefficient	1071:1111	significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L)	1071:1202	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	6	40	theme	X-ray	781:785	arg1	spectroscopy					801:812	X-ray photoelectron spectroscopy	781:812	X-ray photoelectron spectroscopy	781:812	According to scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectrometer, and zeta potential analysis, its adsorption on CS-VTM can be attributed to electrostatic attraction and hydrogen bonds.
32590279	8	41	theme	comparable	1362:1371	arg1	sorbents					1373:1380	the comparable sorbents	1358:1380	the comparable sorbents studied to date	1358:1396	Overall, the CS-VTM proved to be a promising and environmentally friendly adsorbent for the highly efficient and effective removal of organic dyes among the comparable sorbents studied to date.
32590279	3	42	theme	CR	468:469	arg1	adsorption					454:463	adsorption	454:463	adsorption of CR	454:469	The effects of adsorbent dosage, reaction temperature, and initial solution pH on adsorption of CR were investigated.
32590279	3	43	theme	adsorbent	387:395	arg1	dosage					397:402	adsorbent dosage	387:402	adsorbent dosage	387:402	The effects of adsorbent dosage, reaction temperature, and initial solution pH on adsorption of CR were investigated.
32590279	4	44	theme	CR	513:514	arg1	CR					513:514	CR	513:514	CR (100 mg/L)	513:525	Approximately 99.1% of CR (100 mg/L) was adsorbed at a CS-VTM dose of 2.0 g/L or above, while such a reaction was favored at temperatures of 65 °C and pH of 6.0.
32590279	4	44	theme	CR	513:514	arg1	%					508:508	Approximately 99.1%	490:508	Approximately 99.1% of CR (100 mg/L)	490:525	Approximately 99.1% of CR (100 mg/L) was adsorbed at a CS-VTM dose of 2.0 g/L or above, while such a reaction was favored at temperatures of 65 °C and pH of 6.0.
32590279	4	44	theme	CR	513:514	arg1	100 mg/L					517:524	100 mg/L	517:524	100 mg/L	517:524	Approximately 99.1% of CR (100 mg/L) was adsorbed at a CS-VTM dose of 2.0 g/L or above, while such a reaction was favored at temperatures of 65 °C and pH of 6.0.
32590279	6	45	from	adsorption	889:898	arg1	CS-VTM					903:908	CS-VTM	903:908	CS-VTM	903:908	According to scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectrometer, and zeta potential analysis, its adsorption on CS-VTM can be attributed to electrostatic attraction and hydrogen bonds.
32590279	7	46	from	dose	1186:1189	arg1	62.2 mg/g					1170:1178	62.2 mg/g	1170:1178	62.2 mg/g at CR dose of 100 mg/L	1170:1201	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	7	46	from	dose	1186:1189	arg1	capacity					1158:1165	equilibrium adsorption capacity	1135:1165	equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L	1135:1201	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	4	47	theme	2.0 g/L	560:566	arg1	dose					552:555	a CS-VTM dose	543:555	a CS-VTM dose of 2.0 g/L	543:566	Approximately 99.1% of CR (100 mg/L) was adsorbed at a CS-VTM dose of 2.0 g/L or above, while such a reaction was favored at temperatures of 65 °C and pH of 6.0.
32590279	7	48	theme	prepared	980:987	arg1	CS-VTM					989:994	The prepared CS-VTM	976:994	The prepared CS-VTM	976:994	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	6	49	theme	electron	760:767	arg1	microscopy					769:778	scanning electron microscopy	751:778	scanning electron microscopy	751:778	According to scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectrometer, and zeta potential analysis, its adsorption on CS-VTM can be attributed to electrostatic attraction and hydrogen bonds.
32590279	1	50	theme	novel	131:135	arg1	CS					147:148	CS	147:148	CS	147:148	In this research, a novel chitosan (CS)-vanadium-titanium-magnetite (VTM) composite was designed and synthesized.
32590279	1	50	theme	novel	131:135	arg1	chitosan					137:144	a novel chitosan	129:144	a novel chitosan (CS)-vanadium-titanium-magnetite (VTM) composite	129:193	In this research, a novel chitosan (CS)-vanadium-titanium-magnetite (VTM) composite was designed and synthesized.
32590279	6	51	dep	Fourier	815:821	arg1	transform					823:831	transform	823:831	transform infrared spectrometer	823:853	According to scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectrometer, and zeta potential analysis, its adsorption on CS-VTM can be attributed to electrostatic attraction and hydrogen bonds.
32590279	0	52	theme	organic	83:89	arg1	dyes					91:94	organic dyes	83:94	organic dyes in wastewater	83:108	A novel chitosan-vanadium-titanium-magnetite composite as a superior adsorbent for organic dyes in wastewater.
32590279	6	53	theme	scanning	751:758	arg1	microscopy					769:778	scanning electron microscopy	751:778	scanning electron microscopy	751:778	According to scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectrometer, and zeta potential analysis, its adsorption on CS-VTM can be attributed to electrostatic attraction and hydrogen bonds.
32590279	1	54	theme	composite	185:193	arg1	CS					147:148	CS	147:148	CS	147:148	In this research, a novel chitosan (CS)-vanadium-titanium-magnetite (VTM) composite was designed and synthesized.
32590279	1	54	theme	composite	185:193	arg1	chitosan					137:144	a novel chitosan	129:144	a novel chitosan (CS)-vanadium-titanium-magnetite (VTM) composite	129:193	In this research, a novel chitosan (CS)-vanadium-titanium-magnetite (VTM) composite was designed and synthesized.
32590279	7	55	theme	100 mg/L	1194:1201	arg1	dose					1186:1189	CR dose	1183:1189	CR dose of 100 mg/L	1183:1201	The prepared CS-VTM exhibited superior adsorption performance on removal of CR as evidenced by significantly large partition coefficient of 108.3 mg g-1 μM-1 (equilibrium adsorption capacity of 62.2 mg/g at CR dose of 100 mg/L).
32590279	6	56	theme	hydrogen	960:967	arg1	bonds					969:973	hydrogen bonds	960:973	hydrogen bonds	960:973	According to scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectrometer, and zeta potential analysis, its adsorption on CS-VTM can be attributed to electrostatic attraction and hydrogen bonds.
32590279	5	57	theme	CR	689:690	arg1	adsorption					675:684	the adsorption	671:684	the adsorption of CR	671:690	Thermodynamically, the adsorption of CR proceeded spontaneously (ΔG < 0) above 35 °C.
32590279	6	58	theme	potential	865:873	arg1	analysis					875:882	zeta potential analysis	860:882	zeta potential analysis	860:882	According to scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectrometer, and zeta potential analysis, its adsorption on CS-VTM can be attributed to electrostatic attraction and hydrogen bonds.
32590279	6	59	dep	transform	823:831	arg1	infrared					833:840	infrared	833:840	transform infrared spectrometer	823:853	According to scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectrometer, and zeta potential analysis, its adsorption on CS-VTM can be attributed to electrostatic attraction and hydrogen bonds.
33797045	0	0	theme	alginate-zinc	77:89	arg1	beads					125:129	calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads	69:129	calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads	69:129	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.
33797045	2	1	theme	beads	360:364	arg1	properties					320:329	Their physicochemical properties	298:329	Their physicochemical properties of the synthesized composite beads	298:364	Their physicochemical properties of the synthesized composite beads were characterized using various techniques, including FESEM, EDX, FTIR, and TGA.
33797045	0	2	theme	calcium	69:75	arg1	beads					125:129	calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads	69:129	calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads	69:129	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.
33797045	7	3	theme	adsorption	916:925	arg1	capacity					927:934	The adsorption capacity	912:934	The adsorption capacity of the ZCA composite beads for Cs+ and Co2+	912:978	The adsorption capacity of the ZCA composite beads for Cs+ and Co2+ was almost maintained after three times of adsorption-desorption process.
33797045	2	4	theme	composite	350:358	arg1	beads					360:364	the synthesized composite beads	334:364	the synthesized composite beads	334:364	Their physicochemical properties of the synthesized composite beads were characterized using various techniques, including FESEM, EDX, FTIR, and TGA.
33797045	1	5	from	water	291:295	arg1	Co2+					281:284	Co2+	281:284	Co2+	281:284	Composite beads consisting of Ca alginate mixed with zinc ferrocyanide (ZnFC) and Cyanex 272 were synthesized in order to selectively adsorb Cs+ and Co2+ from water.
33797045	1	5	from	water	291:295	arg1	Cs+					273:275	Cs+	273:275	Cs+	273:275	Composite beads consisting of Ca alginate mixed with zinc ferrocyanide (ZnFC) and Cyanex 272 were synthesized in order to selectively adsorb Cs+ and Co2+ from water.
33797045	0	6	theme	ferrocyanide-Cyanex	91:109	arg1	beads					125:129	calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads	69:129	calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads	69:129	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.
33797045	6	7	theme	excellent	799:807	arg1	selectivity					809:819	excellent selectivity	799:819	excellent selectivity toward Cs+ and Co2+	799:839	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	3	8	theme	composite	483:491	arg1	beads					493:497	The ZnFC/Cyanex 272/alginate (ZCA) composite beads	448:497	The ZnFC/Cyanex 272/alginate (ZCA) composite beads	448:497	The ZnFC/Cyanex 272/alginate (ZCA) composite beads were then tested as an adsorbent for the selective removal of Cs+ and Co2+ from an aqueous solution.
33797045	3	8	theme	composite	483:491	arg1	adsorbent					522:530	adsorbent	522:530	adsorbent	522:530	The ZnFC/Cyanex 272/alginate (ZCA) composite beads were then tested as an adsorbent for the selective removal of Cs+ and Co2+ from an aqueous solution.
33797045	5	9	theme	Langmuir	716:723	arg1	model					725:729	the Langmuir model and pseudo-second-order kinetics	712:762	model	725:729	The adsorption process followed the Langmuir model and pseudo-second-order kinetics.
33797045	3	10	theme	ZCA	478:480	arg1	beads					493:497	The ZnFC/Cyanex 272/alginate (ZCA) composite beads	448:497	The ZnFC/Cyanex 272/alginate (ZCA) composite beads	448:497	The ZnFC/Cyanex 272/alginate (ZCA) composite beads were then tested as an adsorbent for the selective removal of Cs+ and Co2+ from an aqueous solution.
33797045	3	10	theme	ZCA	478:480	arg1	adsorbent					522:530	adsorbent	522:530	adsorbent	522:530	The ZnFC/Cyanex 272/alginate (ZCA) composite beads were then tested as an adsorbent for the selective removal of Cs+ and Co2+ from an aqueous solution.
33797045	0	11	theme	composite	115:123	arg1	beads					125:129	calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads	69:129	calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads	69:129	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.
33797045	1	12	theme	zinc	185:188	arg1	ferrocyanide					190:201	zinc ferrocyanide	185:201	zinc ferrocyanide (ZnFC)	185:208	Composite beads consisting of Ca alginate mixed with zinc ferrocyanide (ZnFC) and Cyanex 272 were synthesized in order to selectively adsorb Cs+ and Co2+ from water.
33797045	1	12	theme	zinc	185:188	arg1	ZnFC					204:207	ZnFC	204:207	ZnFC	204:207	Composite beads consisting of Ca alginate mixed with zinc ferrocyanide (ZnFC) and Cyanex 272 were synthesized in order to selectively adsorb Cs+ and Co2+ from water.
33797045	0	13	theme	selective	13:21	arg1	removal					23:29	Simultaneous selective removal	0:29	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.	0:130	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.
33797045	6	14	theme	competitive	865:875	arg1	Ni2+					905:908	Ni2+	905:908	Ni2+	905:908	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	6	14	theme	competitive	865:875	arg1	Na+					890:892	Na+	890:892	Na+	890:892	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	6	14	theme	competitive	865:875	arg1	K+					886:887	K+	886:887	K+	886:887	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	6	14	theme	competitive	865:875	arg1	cations					877:883	competitive cations	865:883	competitive cations (K+, Na+, Fe2+, and Ni2+)	865:909	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	6	14	theme	competitive	865:875	arg1	Fe2+					895:898	Fe2+	895:898	Fe2+	895:898	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	7	15	theme	adsorption-desorption	1023:1043	arg1	process					1045:1051	adsorption-desorption process	1023:1051	adsorption-desorption process	1023:1051	The adsorption capacity of the ZCA composite beads for Cs+ and Co2+ was almost maintained after three times of adsorption-desorption process.
33797045	6	16	theme	composite	773:781	arg1	beads					783:787	The ZCA composite beads	765:787	The ZCA composite beads	765:787	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	2	17	theme	physicochemical	304:318	arg1	properties					320:329	Their physicochemical properties	298:329	Their physicochemical properties of the synthesized composite beads	298:364	Their physicochemical properties of the synthesized composite beads were characterized using various techniques, including FESEM, EDX, FTIR, and TGA.
33797045	3	18	from	solution	590:597	arg1	removal					550:556	the selective removal	536:556	the selective removal of Cs+ and Co2+ from an aqueous solution	536:597	The ZnFC/Cyanex 272/alginate (ZCA) composite beads were then tested as an adsorbent for the selective removal of Cs+ and Co2+ from an aqueous solution.
33797045	2	19	theme	various	391:397	arg1	techniques					399:408	various techniques	391:408	various techniques	391:408	Their physicochemical properties of the synthesized composite beads were characterized using various techniques, including FESEM, EDX, FTIR, and TGA.
33797045	2	19	theme	various	391:397	arg1	FESEM					421:425	FESEM	421:425	FESEM	421:425	Their physicochemical properties of the synthesized composite beads were characterized using various techniques, including FESEM, EDX, FTIR, and TGA.
33797045	2	19	theme	various	391:397	arg1	FTIR					433:436	FTIR	433:436	FTIR	433:436	Their physicochemical properties of the synthesized composite beads were characterized using various techniques, including FESEM, EDX, FTIR, and TGA.
33797045	2	19	theme	various	391:397	arg1	TGA					443:445	TGA	443:445	TGA	443:445	Their physicochemical properties of the synthesized composite beads were characterized using various techniques, including FESEM, EDX, FTIR, and TGA.
33797045	2	19	theme	various	391:397	arg1	EDX					428:430	EDX	428:430	EDX	428:430	Their physicochemical properties of the synthesized composite beads were characterized using various techniques, including FESEM, EDX, FTIR, and TGA.
33797045	0	20	theme	Simultaneous	0:11	arg1	removal					23:29	Simultaneous selective removal	0:29	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.	0:130	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.
33797045	7	21	theme	process	1045:1051	arg1	times					1014:1018	three times	1008:1018	three times of adsorption-desorption process	1008:1051	The adsorption capacity of the ZCA composite beads for Cs+ and Co2+ was almost maintained after three times of adsorption-desorption process.
33797045	6	22	theme	ZCA	769:771	arg1	beads					783:787	The ZCA composite beads	765:787	The ZCA composite beads	765:787	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	3	23	theme	ZnFC/Cyanex	452:462	arg1	beads					493:497	The ZnFC/Cyanex 272/alginate (ZCA) composite beads	448:497	The ZnFC/Cyanex 272/alginate (ZCA) composite beads	448:497	The ZnFC/Cyanex 272/alginate (ZCA) composite beads were then tested as an adsorbent for the selective removal of Cs+ and Co2+ from an aqueous solution.
33797045	3	23	theme	ZnFC/Cyanex	452:462	arg1	adsorbent					522:530	adsorbent	522:530	adsorbent	522:530	The ZnFC/Cyanex 272/alginate (ZCA) composite beads were then tested as an adsorbent for the selective removal of Cs+ and Co2+ from an aqueous solution.
33797045	5	24	theme	adsorption	684:693	arg1	process					695:701	The adsorption process	680:701	The adsorption process	680:701	The adsorption process followed the Langmuir model and pseudo-second-order kinetics.
33797045	0	25	theme	cesium	34:39	arg1	removal					23:29	Simultaneous selective removal	0:29	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.	0:130	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.
33797045	3	26	theme	Co2+	569:572	arg1	removal					550:556	the selective removal	536:556	the selective removal of Cs+ and Co2+ from an aqueous solution	536:597	The ZnFC/Cyanex 272/alginate (ZCA) composite beads were then tested as an adsorbent for the selective removal of Cs+ and Co2+ from an aqueous solution.
33797045	4	27	theme	adsorption	604:613	arg1	capacity					615:622	The adsorption capacity	600:622	The adsorption capacity	600:622	The adsorption capacity increased with increasing ZnFC and Cyanex 272 contents.
33797045	0	28	from	water	57:61	arg1	removal					23:29	Simultaneous selective removal	0:29	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.	0:130	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.
33797045	2	29	theme	synthesized	338:348	arg1	beads					360:364	the synthesized composite beads	334:364	the synthesized composite beads	334:364	Their physicochemical properties of the synthesized composite beads were characterized using various techniques, including FESEM, EDX, FTIR, and TGA.
33797045	0	30	theme	cobalt	45:50	arg1	removal					23:29	Simultaneous selective removal	0:29	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.	0:130	Simultaneous selective removal of cesium and cobalt from water using calcium alginate-zinc ferrocyanide-Cyanex 272 composite beads.
33797045	3	31	theme	Cs+	561:563	arg1	removal					550:556	the selective removal	536:556	the selective removal of Cs+ and Co2+ from an aqueous solution	536:597	The ZnFC/Cyanex 272/alginate (ZCA) composite beads were then tested as an adsorbent for the selective removal of Cs+ and Co2+ from an aqueous solution.
33797045	7	32	theme	beads	957:961	arg1	capacity					927:934	The adsorption capacity	912:934	The adsorption capacity of the ZCA composite beads for Cs+ and Co2+	912:978	The adsorption capacity of the ZCA composite beads for Cs+ and Co2+ was almost maintained after three times of adsorption-desorption process.
33797045	1	33	theme	Composite	132:140	arg1	beads					142:146	Composite beads	132:146	Composite beads consisting of Ca alginate mixed with zinc ferrocyanide (ZnFC) and Cyanex 272	132:223	Composite beads consisting of Ca alginate mixed with zinc ferrocyanide (ZnFC) and Cyanex 272 were synthesized in order to selectively adsorb Cs+ and Co2+ from water.
33797045	3	34	theme	selective	540:548	arg1	removal					550:556	the selective removal	536:556	the selective removal of Cs+ and Co2+ from an aqueous solution	536:597	The ZnFC/Cyanex 272/alginate (ZCA) composite beads were then tested as an adsorbent for the selective removal of Cs+ and Co2+ from an aqueous solution.
33797045	3	35	theme	aqueous	582:588	arg1	solution					590:597	an aqueous solution	579:597	an aqueous solution	579:597	The ZnFC/Cyanex 272/alginate (ZCA) composite beads were then tested as an adsorbent for the selective removal of Cs+ and Co2+ from an aqueous solution.
33797045	3	36	theme	272/alginate	464:475	arg1	beads					493:497	The ZnFC/Cyanex 272/alginate (ZCA) composite beads	448:497	The ZnFC/Cyanex 272/alginate (ZCA) composite beads	448:497	The ZnFC/Cyanex 272/alginate (ZCA) composite beads were then tested as an adsorbent for the selective removal of Cs+ and Co2+ from an aqueous solution.
33797045	3	36	theme	272/alginate	464:475	arg1	adsorbent					522:530	adsorbent	522:530	adsorbent	522:530	The ZnFC/Cyanex 272/alginate (ZCA) composite beads were then tested as an adsorbent for the selective removal of Cs+ and Co2+ from an aqueous solution.
33797045	6	37	dep	cations	877:883	arg1	Na+					890:892	Na+	890:892	Na+	890:892	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	6	37	dep	cations	877:883	arg1	Fe2+					895:898	Fe2+	895:898	Fe2+	895:898	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	6	37	dep	cations	877:883	arg1	cations					877:883	competitive cations	865:883	competitive cations (K+, Na+, Fe2+, and Ni2+)	865:909	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	6	37	dep	cations	877:883	arg1	K+					886:887	K+	886:887	K+	886:887	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	6	37	dep	cations	877:883	arg1	Ni2+					905:908	Ni2+	905:908	Ni2+	905:908	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	6	37	dep	cations	877:883	arg1	the					849:851	the	849:851	the	849:851	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	6	37	dep	cations	877:883	arg1	presence					853:860	presence	853:860	presence	853:860	The ZCA composite beads exhibited excellent selectivity toward Cs+ and Co2+ even in the presence of competitive cations (K+, Na+, Fe2+, and Ni2+).
33797045	7	38	theme	ZCA	943:945	arg1	beads					957:961	the ZCA composite beads	939:961	the ZCA composite beads	939:961	The adsorption capacity of the ZCA composite beads for Cs+ and Co2+ was almost maintained after three times of adsorption-desorption process.
33797045	7	39	theme	composite	947:955	arg1	beads					957:961	the ZCA composite beads	939:961	the ZCA composite beads	939:961	The adsorption capacity of the ZCA composite beads for Cs+ and Co2+ was almost maintained after three times of adsorption-desorption process.
33797045	4	40	theme	Cyanex	659:664	arg1	contents					670:677	Cyanex 272 contents	659:677	Cyanex 272 contents	659:677	The adsorption capacity increased with increasing ZnFC and Cyanex 272 contents.
33797045	5	41	theme	pseudo-second-order	735:753	arg1	kinetics					755:762	the Langmuir model and pseudo-second-order kinetics	712:762	kinetics	755:762	The adsorption process followed the Langmuir model and pseudo-second-order kinetics.
33797045	1	42	theme	Ca	162:163	arg1	alginate					165:172	Ca alginate	162:172	Ca alginate mixed with zinc ferrocyanide (ZnFC) and Cyanex 272	162:223	Composite beads consisting of Ca alginate mixed with zinc ferrocyanide (ZnFC) and Cyanex 272 were synthesized in order to selectively adsorb Cs+ and Co2+ from water.
34976318	0	0	theme	rumen	72:76	arg1	microbiota					78:87	the rumen microbiota	68:87	the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses	68:161	Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses.
34976318	6	1	theme	batch	1308:1312	arg1	cultures					1314:1321	batch cultures	1308:1321	batch cultures	1308:1321	To determine if the rumen microbiota can further saccharify the residual plant polysaccharides within TTIR, rumen microbiota from cattle fed a diet containing BS were incubated with BS and TTIR ex vivo in batch cultures.
34976318	6	2	theme	rumen	1123:1127	arg1	microbiota					1129:1138	the rumen microbiota	1119:1138	the rumen microbiota	1119:1138	To determine if the rumen microbiota can further saccharify the residual plant polysaccharides within TTIR, rumen microbiota from cattle fed a diet containing BS were incubated with BS and TTIR ex vivo in batch cultures.
34976318	6	3	from	cattle	1233:1238	arg1	microbiota					1217:1226	rumen microbiota	1211:1226	rumen microbiota from cattle fed a diet containing BS	1211:1263	To determine if the rumen microbiota can further saccharify the residual plant polysaccharides within TTIR, rumen microbiota from cattle fed a diet containing BS were incubated with BS and TTIR ex vivo in batch cultures.
34976318	1	4	theme	cell	254:257	arg1	walls					259:263	plant cell walls	248:263	plant cell walls	248:263	There is a knowledge gap regarding the factors that impede the ruminal digestion of plant cell walls or if rumen microbiota possess the functional activities to overcome these constraints.
34976318	2	5	theme	microbial	518:526	arg1	digestion					528:536	microbial digestion	518:536	microbial digestion	518:536	Innovative experimental methods were adopted to provide a high-resolution understanding of plant cell wall chemistries, identify higher-order structures that resist microbial digestion, and determine how they interact with the functional activities of the rumen microbiota.
34976318	3	6	theme	straw	718:722	arg1	diet					724:727	a low-quality straw diet	704:727	a low-quality straw diet	704:727	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	2	7	theme	experimental	364:375	arg1	methods					377:383	Innovative experimental methods	353:383	Innovative experimental methods	353:383	Innovative experimental methods were adopted to provide a high-resolution understanding of plant cell wall chemistries, identify higher-order structures that resist microbial digestion, and determine how they interact with the functional activities of the rumen microbiota.
34976318	1	8	theme	walls	259:263	arg1	digestion					235:243	the ruminal digestion	223:243	the ruminal digestion of plant cell walls or if rumen microbiota	223:286	There is a knowledge gap regarding the factors that impede the ruminal digestion of plant cell walls or if rumen microbiota possess the functional activities to overcome these constraints.
34976318	8	9	theme	sequences	1616:1624	arg1	CAZymes					1634:1640	CAZymes	1634:1640	CAZymes with activities predicted to cleave the primary linkages within heteroxylan and arabinan	1634:1729	High-resolution phylogenetic fingerprinting of these sequences encoded CAZymes with activities predicted to cleave the primary linkages within heteroxylan and arabinan.
34976318	8	9	theme	sequences	1616:1624	arg1	fingerprinting					1592:1605	High-resolution phylogenetic fingerprinting	1563:1605	High-resolution phylogenetic fingerprinting of these sequences	1563:1624	High-resolution phylogenetic fingerprinting of these sequences encoded CAZymes with activities predicted to cleave the primary linkages within heteroxylan and arabinan.
34976318	4	10	from	epitopes	914:921	arg1	BS					940:941	BS	940:941	BS	940:941	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	4	10	from	epitopes	914:921	arg1	TTIR					948:951	TTIR	948:951	TTIR	948:951	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	4	10	from	epitopes	914:921	arg1	straw					933:937	barley straw	926:937	barley straw (BS)	926:942	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	9	11	theme	experimental	1737:1748	arg1	platform					1750:1757	This experimental platform	1732:1757	This experimental platform	1732:1757	This experimental platform provides unprecedented precision in the understanding of forage structure and digestibility, which can be extended to other feed-host systems and inform next-generation solutions to improve the performance of ruminants fed low-quality forages.
34976318	9	12	theme	next-generation	1912:1926	arg1	solutions					1928:1936	next-generation solutions	1912:1936	next-generation solutions	1912:1936	This experimental platform provides unprecedented precision in the understanding of forage structure and digestibility, which can be extended to other feed-host systems and inform next-generation solutions to improve the performance of ruminants fed low-quality forages.
34976318	4	13	theme	relative	974:981	arg1	abundance					983:991	their relative abundance	968:991	their relative abundance pre-	968:996	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	7	14	theme	comparative	1493:1503	arg1	profiles					1521:1528	comparative gene expression profiles	1493:1528	comparative gene expression profiles	1493:1528	Transcripts coding for carbohydrate-active enzymes (CAZymes) were identified and characterized for their contribution to cell wall digestion based on glycomic analyses, comparative gene expression profiles, and associated CAZyme families.
34976318	4	15	theme	barley	926:931	arg1	BS					940:941	BS	940:941	BS	940:941	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	4	15	theme	barley	926:931	arg1	straw					933:937	barley straw	926:937	barley straw (BS)	926:942	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	7	16	theme	glycomic	1474:1481	arg1	analyses					1483:1490	glycomic analyses	1474:1490	glycomic analyses	1474:1490	Transcripts coding for carbohydrate-active enzymes (CAZymes) were identified and characterized for their contribution to cell wall digestion based on glycomic analyses, comparative gene expression profiles, and associated CAZyme families.
34976318	0	17	theme	high-resolution	109:123	arg1	glycomics					125:133	combinatorial high-resolution glycomics	95:133	combinatorial high-resolution glycomics	95:133	Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses.
34976318	6	18	theme	residual	1167:1174	arg1	polysaccharides					1182:1196	the residual plant polysaccharides	1163:1196	the residual plant polysaccharides within TTIR	1163:1208	To determine if the rumen microbiota can further saccharify the residual plant polysaccharides within TTIR, rumen microbiota from cattle fed a diet containing BS were incubated with BS and TTIR ex vivo in batch cultures.
34976318	4	19	theme	cell	897:900	arg1	epitopes					914:921	numerous and diverse cell wall glycan epitopes	876:921	numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR	876:951	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	1	20	theme	knowledge	175:183	arg1	gap					185:187	a knowledge gap	173:187	a knowledge gap regarding the factors that impede the ruminal digestion of plant cell walls or if rumen microbiota possess the functional activities to overcome these constraints	173:350	There is a knowledge gap regarding the factors that impede the ruminal digestion of plant cell walls or if rumen microbiota possess the functional activities to overcome these constraints.
34976318	0	21	theme	combinatorial	95:107	arg1	glycomics					125:133	combinatorial high-resolution glycomics	95:133	combinatorial high-resolution glycomics	95:133	Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses.
34976318	3	22	theme	comparative	739:749	arg1	approaches					760:769	two comparative glycomic approaches	735:769	two comparative glycomic approaches	735:769	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	4	23	theme	diverse	889:895	arg1	epitopes					914:921	numerous and diverse cell wall glycan epitopes	876:921	numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR	876:951	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	8	24	theme	phylogenetic	1579:1590	arg1	CAZymes					1634:1640	CAZymes	1634:1640	CAZymes with activities predicted to cleave the primary linkages within heteroxylan and arabinan	1634:1729	High-resolution phylogenetic fingerprinting of these sequences encoded CAZymes with activities predicted to cleave the primary linkages within heteroxylan and arabinan.
34976318	8	24	theme	phylogenetic	1579:1590	arg1	fingerprinting					1592:1605	High-resolution phylogenetic fingerprinting	1563:1605	High-resolution phylogenetic fingerprinting of these sequences	1563:1624	High-resolution phylogenetic fingerprinting of these sequences encoded CAZymes with activities predicted to cleave the primary linkages within heteroxylan and arabinan.
34976318	9	25	theme	unprecedented	1768:1780	arg1	precision					1782:1790	unprecedented precision	1768:1790	unprecedented precision in the understanding of forage structure and digestibility, which can be extended to other feed-host systems and inform next-generation solutions to improve the performance of ruminants fed low-quality forages	1768:2000	This experimental platform provides unprecedented precision in the understanding of forage structure and digestibility, which can be extended to other feed-host systems and inform next-generation solutions to improve the performance of ruminants fed low-quality forages.
34976318	8	26	theme	primary	1682:1688	arg1	linkages					1690:1697	the primary linkages	1678:1697	the primary linkages	1678:1697	High-resolution phylogenetic fingerprinting of these sequences encoded CAZymes with activities predicted to cleave the primary linkages within heteroxylan and arabinan.
34976318	3	27	theme	glycomic	751:758	arg1	approaches					760:769	two comparative glycomic approaches	735:769	two comparative glycomic approaches	735:769	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	4	28	theme	glycan	907:912	arg1	epitopes					914:921	numerous and diverse cell wall glycan epitopes	876:921	numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR	876:951	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	4	29	theme	tract	1013:1017	arg1	digestion					1019:1027	post-total tract digestion	1002:1027	post-total tract digestion	1002:1027	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	7	30	theme	cell	1445:1448	arg1	digestion					1455:1463	cell wall digestion	1445:1463	cell wall digestion	1445:1463	Transcripts coding for carbohydrate-active enzymes (CAZymes) were identified and characterized for their contribution to cell wall digestion based on glycomic analyses, comparative gene expression profiles, and associated CAZyme families.
34976318	7	31	theme	gene	1505:1508	arg1	profiles					1521:1528	comparative gene expression profiles	1493:1528	comparative gene expression profiles	1493:1528	Transcripts coding for carbohydrate-active enzymes (CAZymes) were identified and characterized for their contribution to cell wall digestion based on glycomic analyses, comparative gene expression profiles, and associated CAZyme families.
34976318	3	32	dep	characterized	630:642	arg1	profiling					792:800	ELISA-based glycome profiling	772:800	ELISA-based glycome profiling	772:800	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	3	32	dep	characterized	630:642	arg1	wall					817:820	total cell wall	806:820	total cell wall	806:820	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	0	33	theme	Mechanistic	0:10	arg1	insights					12:19	Mechanistic insights	0:19	Mechanistic insights into the digestion of complex	0:49	Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses.
34976318	1	34	theme	rumen	271:275	arg1	microbiota					277:286	rumen microbiota	271:286	rumen microbiota	271:286	There is a knowledge gap regarding the factors that impede the ruminal digestion of plant cell walls or if rumen microbiota possess the functional activities to overcome these constraints.
34976318	4	35	theme	wall	902:905	arg1	epitopes					914:921	numerous and diverse cell wall glycan epitopes	876:921	numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR	876:951	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	5	36	theme	higher	1077:1082	arg1	abundance					1084:1092	higher abundance	1077:1092	higher abundance	1077:1092	Of these, xyloglucans and heteroxylans were of higher abundance in TTIR.
34976318	7	37	theme	carbohydrate-active	1347:1365	arg1	CAZymes					1376:1382	CAZymes	1376:1382	CAZymes	1376:1382	Transcripts coding for carbohydrate-active enzymes (CAZymes) were identified and characterized for their contribution to cell wall digestion based on glycomic analyses, comparative gene expression profiles, and associated CAZyme families.
34976318	7	37	theme	carbohydrate-active	1347:1365	arg1	enzymes					1367:1373	carbohydrate-active enzymes	1347:1373	carbohydrate-active enzymes (CAZymes)	1347:1383	Transcripts coding for carbohydrate-active enzymes (CAZymes) were identified and characterized for their contribution to cell wall digestion based on glycomic analyses, comparative gene expression profiles, and associated CAZyme families.
34976318	2	38	theme	chemistries	460:470	arg1	understanding					427:439	a high-resolution understanding	409:439	a high-resolution understanding of plant cell wall chemistries	409:470	Innovative experimental methods were adopted to provide a high-resolution understanding of plant cell wall chemistries, identify higher-order structures that resist microbial digestion, and determine how they interact with the functional activities of the rumen microbiota.
34976318	7	39	theme	wall	1450:1453	arg1	digestion					1455:1463	cell wall digestion	1445:1463	cell wall digestion	1445:1463	Transcripts coding for carbohydrate-active enzymes (CAZymes) were identified and characterized for their contribution to cell wall digestion based on glycomic analyses, comparative gene expression profiles, and associated CAZyme families.
34976318	9	40	theme	other	1877:1881	arg1	systems					1893:1899	other feed-host systems	1877:1899	other feed-host systems	1877:1899	This experimental platform provides unprecedented precision in the understanding of forage structure and digestibility, which can be extended to other feed-host systems and inform next-generation solutions to improve the performance of ruminants fed low-quality forages.
34976318	4	41	theme	numerous	876:883	arg1	epitopes					914:921	numerous and diverse cell wall glycan epitopes	876:921	numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR	876:951	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	5	42	from	abundance	1084:1092	arg1	TTIR					1097:1100	TTIR	1097:1100	TTIR	1097:1100	Of these, xyloglucans and heteroxylans were of higher abundance in TTIR.
34976318	2	43	theme	cell	450:453	arg1	chemistries					460:470	plant cell wall chemistries	444:470	plant cell wall chemistries	444:470	Innovative experimental methods were adopted to provide a high-resolution understanding of plant cell wall chemistries, identify higher-order structures that resist microbial digestion, and determine how they interact with the functional activities of the rumen microbiota.
34976318	2	44	theme	wall	455:458	arg1	chemistries					460:470	plant cell wall chemistries	444:470	plant cell wall chemistries	444:470	Innovative experimental methods were adopted to provide a high-resolution understanding of plant cell wall chemistries, identify higher-order structures that resist microbial digestion, and determine how they interact with the functional activities of the rumen microbiota.
34976318	3	45	theme	ELISA-based	772:782	arg1	profiling					792:800	ELISA-based glycome profiling	772:800	ELISA-based glycome profiling	772:800	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	2	46	theme	functional	580:589	arg1	activities					591:600	the functional activities	576:600	the functional activities of the rumen microbiota	576:624	Innovative experimental methods were adopted to provide a high-resolution understanding of plant cell wall chemistries, identify higher-order structures that resist microbial digestion, and determine how they interact with the functional activities of the rumen microbiota.
34976318	6	47	theme	plant	1176:1180	arg1	polysaccharides					1182:1196	the residual plant polysaccharides	1163:1196	the residual plant polysaccharides within TTIR	1163:1208	To determine if the rumen microbiota can further saccharify the residual plant polysaccharides within TTIR, rumen microbiota from cattle fed a diet containing BS were incubated with BS and TTIR ex vivo in batch cultures.
34976318	2	48	theme	plant	444:448	arg1	chemistries					460:470	plant cell wall chemistries	444:470	plant cell wall chemistries	444:470	Innovative experimental methods were adopted to provide a high-resolution understanding of plant cell wall chemistries, identify higher-order structures that resist microbial digestion, and determine how they interact with the functional activities of the rumen microbiota.
34976318	3	49	theme	glycome	784:790	arg1	profiling					792:800	ELISA-based glycome profiling	772:800	ELISA-based glycome profiling	772:800	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	8	50	with	CAZymes	1634:1640	arg1	activities					1647:1656	activities	1647:1656	activities predicted to cleave the primary linkages within heteroxylan and arabinan	1647:1729	High-resolution phylogenetic fingerprinting of these sequences encoded CAZymes with activities predicted to cleave the primary linkages within heteroxylan and arabinan.
34976318	2	51	theme	high-resolution	411:425	arg1	understanding					427:439	a high-resolution understanding	409:439	a high-resolution understanding of plant cell wall chemistries	409:470	Innovative experimental methods were adopted to provide a high-resolution understanding of plant cell wall chemistries, identify higher-order structures that resist microbial digestion, and determine how they interact with the functional activities of the rumen microbiota.
34976318	1	52	theme	functional	300:309	arg1	activities					311:320	the functional activities	296:320	the functional activities to overcome these constraints	296:350	There is a knowledge gap regarding the factors that impede the ruminal digestion of plant cell walls or if rumen microbiota possess the functional activities to overcome these constraints.
34976318	0	53	theme	transcriptomic	139:152	arg1	analyses					154:161	transcriptomic analyses	139:161	transcriptomic analyses	139:161	Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses.
34976318	7	54	theme	expression	1510:1519	arg1	profiles					1521:1528	comparative gene expression profiles	1493:1528	comparative gene expression profiles	1493:1528	Transcripts coding for carbohydrate-active enzymes (CAZymes) were identified and characterized for their contribution to cell wall digestion based on glycomic analyses, comparative gene expression profiles, and associated CAZyme families.
34976318	9	55	theme	feed-host	1883:1891	arg1	systems					1893:1899	other feed-host systems	1877:1899	other feed-host systems	1877:1899	This experimental platform provides unprecedented precision in the understanding of forage structure and digestibility, which can be extended to other feed-host systems and inform next-generation solutions to improve the performance of ruminants fed low-quality forages.
34976318	4	56	theme	pre-	993:996	arg1	abundance					983:991	their relative abundance	968:991	their relative abundance pre-	968:996	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	3	57	theme	glycosidic	822:831	arg1	analysis					841:848	glycosidic linkage analysis	822:848	glycosidic linkage analysis	822:848	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	2	58	theme	microbiota	615:624	arg1	activities					591:600	the functional activities	576:600	the functional activities of the rumen microbiota	576:624	Innovative experimental methods were adopted to provide a high-resolution understanding of plant cell wall chemistries, identify higher-order structures that resist microbial digestion, and determine how they interact with the functional activities of the rumen microbiota.
34976318	2	59	theme	Innovative	353:362	arg1	methods					377:383	Innovative experimental methods	353:383	Innovative experimental methods	353:383	Innovative experimental methods were adopted to provide a high-resolution understanding of plant cell wall chemistries, identify higher-order structures that resist microbial digestion, and determine how they interact with the functional activities of the rumen microbiota.
34976318	0	60	theme	complex	43:49	arg1	digestion					30:38	the digestion	26:38	the digestion of complex	26:49	Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses.
34976318	3	61	theme	total	806:810	arg1	wall					817:820	total cell wall	806:820	total cell wall	806:820	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	2	62	theme	rumen	609:613	arg1	microbiota					615:624	the rumen microbiota	605:624	the rumen microbiota	605:624	Innovative experimental methods were adopted to provide a high-resolution understanding of plant cell wall chemistries, identify higher-order structures that resist microbial digestion, and determine how they interact with the functional activities of the rumen microbiota.
34976318	2	63	theme	higher-order	482:493	arg1	structures					495:504	higher-order structures	482:504	higher-order structures that resist microbial digestion	482:536	Innovative experimental methods were adopted to provide a high-resolution understanding of plant cell wall chemistries, identify higher-order structures that resist microbial digestion, and determine how they interact with the functional activities of the rumen microbiota.
34976318	3	64	theme	low-quality	706:716	arg1	diet					724:727	a low-quality straw diet	704:727	a low-quality straw diet	704:727	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	6	65	contain	containing	1251:1260	arg2	BS					1262:1263	BS	1262:1263	BS	1262:1263	To determine if the rumen microbiota can further saccharify the residual plant polysaccharides within TTIR, rumen microbiota from cattle fed a diet containing BS were incubated with BS and TTIR ex vivo in batch cultures.
34976318	6	65	contain	containing	1251:1260	arg1	diet					1246:1249	a diet	1244:1249	a diet containing BS	1244:1263	To determine if the rumen microbiota can further saccharify the residual plant polysaccharides within TTIR, rumen microbiota from cattle fed a diet containing BS were incubated with BS and TTIR ex vivo in batch cultures.
34976318	3	66	theme	cell	812:815	arg1	wall					817:820	total cell wall	806:820	total cell wall	806:820	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	3	67	theme	indigestible	660:671	arg1	TTIR					682:685	TTIR	682:685	TTIR	682:685	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	3	67	theme	indigestible	660:671	arg1	residue					673:679	the total tract indigestible residue	644:679	the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet	644:727	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	1	68	dep	impede	216:221	arg1	possess					288:294	possess	288:294	possess the functional activities to overcome these constraints	288:350	There is a knowledge gap regarding the factors that impede the ruminal digestion of plant cell walls or if rumen microbiota possess the functional activities to overcome these constraints.
34976318	9	69	theme	ruminants	1968:1976	arg1	performance					1953:1963	the performance	1949:1963	the performance of ruminants fed low-quality forages	1949:2000	This experimental platform provides unprecedented precision in the understanding of forage structure and digestibility, which can be extended to other feed-host systems and inform next-generation solutions to improve the performance of ruminants fed low-quality forages.
34976318	1	70	theme	ruminal	227:233	arg1	digestion					235:243	the ruminal digestion	223:243	the ruminal digestion of plant cell walls or if rumen microbiota	223:286	There is a knowledge gap regarding the factors that impede the ruminal digestion of plant cell walls or if rumen microbiota possess the functional activities to overcome these constraints.
34976318	8	71	theme	High-resolution	1563:1577	arg1	CAZymes					1634:1640	CAZymes	1634:1640	CAZymes with activities predicted to cleave the primary linkages within heteroxylan and arabinan	1634:1729	High-resolution phylogenetic fingerprinting of these sequences encoded CAZymes with activities predicted to cleave the primary linkages within heteroxylan and arabinan.
34976318	8	71	theme	High-resolution	1563:1577	arg1	fingerprinting					1592:1605	High-resolution phylogenetic fingerprinting	1563:1605	High-resolution phylogenetic fingerprinting of these sequences	1563:1624	High-resolution phylogenetic fingerprinting of these sequences encoded CAZymes with activities predicted to cleave the primary linkages within heteroxylan and arabinan.
34976318	7	72	theme	associated	1535:1544	arg1	families					1553:1560	associated CAZyme families	1535:1560	associated CAZyme families	1535:1560	Transcripts coding for carbohydrate-active enzymes (CAZymes) were identified and characterized for their contribution to cell wall digestion based on glycomic analyses, comparative gene expression profiles, and associated CAZyme families.
34976318	5	73	theme	these	1033:1037	arg1	abundance					1084:1092	higher abundance	1077:1092	higher abundance	1077:1092	Of these, xyloglucans and heteroxylans were of higher abundance in TTIR.
34976318	3	74	from	cattle	693:698	arg1	TTIR					682:685	TTIR	682:685	TTIR	682:685	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	3	74	from	cattle	693:698	arg1	residue					673:679	the total tract indigestible residue	644:679	the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet	644:727	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	7	75	theme	CAZyme	1546:1551	arg1	families					1553:1560	associated CAZyme families	1535:1560	associated CAZyme families	1535:1560	Transcripts coding for carbohydrate-active enzymes (CAZymes) were identified and characterized for their contribution to cell wall digestion based on glycomic analyses, comparative gene expression profiles, and associated CAZyme families.
34976318	3	76	theme	total	648:652	arg1	TTIR					682:685	TTIR	682:685	TTIR	682:685	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	3	76	theme	total	648:652	arg1	residue					673:679	the total tract indigestible residue	644:679	the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet	644:727	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	9	77	from	precision	1782:1790	arg1	understanding					1799:1811	the understanding	1795:1811	the understanding of forage structure and digestibility, which can be extended to other feed-host systems and inform next-generation solutions	1795:1936	This experimental platform provides unprecedented precision in the understanding of forage structure and digestibility, which can be extended to other feed-host systems and inform next-generation solutions to improve the performance of ruminants fed low-quality forages.
34976318	9	78	theme	low-quality	1982:1992	arg1	forages					1994:2000	low-quality forages	1982:2000	low-quality forages	1982:2000	This experimental platform provides unprecedented precision in the understanding of forage structure and digestibility, which can be extended to other feed-host systems and inform next-generation solutions to improve the performance of ruminants fed low-quality forages.
34976318	3	79	theme	linkage	833:839	arg1	analysis					841:848	glycosidic linkage analysis	822:848	glycosidic linkage analysis	822:848	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	4	80	theme	post-total	1002:1011	arg1	digestion					1019:1027	post-total tract digestion	1002:1027	post-total tract digestion	1002:1027	We successfully detected numerous and diverse cell wall glycan epitopes in barley straw (BS) and TTIR and determined their relative abundance pre- and post-total tract digestion.
34976318	3	81	dep	profiling	792:800	arg1	analysis					841:848	glycosidic linkage analysis	822:848	glycosidic linkage analysis	822:848	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	3	82	theme	tract	654:658	arg1	TTIR					682:685	TTIR	682:685	TTIR	682:685	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	3	82	theme	tract	654:658	arg1	residue					673:679	the total tract indigestible residue	644:679	the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet	644:727	We characterized the total tract indigestible residue (TTIR) from cattle fed a low-quality straw diet using two comparative glycomic approaches: ELISA-based glycome profiling and total cell wall glycosidic linkage analysis.
34976318	1	83	theme	plant	248:252	arg1	walls					259:263	plant cell walls	248:263	plant cell walls	248:263	There is a knowledge gap regarding the factors that impede the ruminal digestion of plant cell walls or if rumen microbiota possess the functional activities to overcome these constraints.
32079004	1	0	theme	cord	166:169	arg1	trauma					195:200	a devastating trauma	181:200	a devastating trauma	181:200	Spinal cord injury is a devastating trauma with high mortality and disability, for which there is no effective treatment.
32079004	1	0	theme	cord	166:169	arg1	injury					171:176	Spinal cord injury	159:176	Spinal cord injury	159:176	Spinal cord injury is a devastating trauma with high mortality and disability, for which there is no effective treatment.
32079004	6	1	theme	injury	1379:1384	arg1	model					1386:1390	a murine spinal cord injury model	1358:1390	a murine spinal cord injury model	1358:1390	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	4	2	theme	thermosensitive	509:523	arg1	hydrogel					535:542	a new thermosensitive composite hydrogel	503:542	a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel)	503:642	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	2	3	theme	neural	356:361	arg1	recovery					363:370	functional neural recovery	345:370	functional neural recovery	345:370	Stem cell-based tissue engineering has been reported to promote functional neural recovery.
32079004	0	4	theme	function	112:119	arg1	recovery					121:128	motor function recovery	106:128	motor function recovery in spinal cord injured mice	106:156	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells promotes motor function recovery in spinal cord injured mice.
32079004	4	5	theme	new	505:507	arg1	hydrogel					535:542	a new thermosensitive composite hydrogel	503:542	a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel)	503:642	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	6	6	theme	function	1329:1336	arg1	recovery					1311:1318	the recovery	1307:1318	the recovery of motor function in the hindlimbs of a murine spinal cord injury model	1307:1390	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	6	7	from	experiments	1085:1095	arg1	data					1068:1071	the data	1064:1071	the data from animal experiments	1064:1095	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	2	8	theme	cell-based	286:295	arg1	engineering					304:314	Stem cell-based tissue engineering	281:314	Stem cell-based tissue engineering	281:314	Stem cell-based tissue engineering has been reported to promote functional neural recovery.
32079004	4	9	theme	spinal	765:770	arg1	cord					772:775	spinal cord	765:775	spinal cord injured mice	765:788	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	3	10	theme	neural	396:401	arg1	scaffold					403:410	a neural scaffold	394:410	a neural scaffold with excellent biocompatibility for cells and tissues	394:464	At present, building a neural scaffold with excellent biocompatibility for cells and tissues is still challenging.
32079004	0	11	theme	motor	106:110	arg1	recovery					121:128	motor function recovery	106:128	motor function recovery in spinal cord injured mice	106:156	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells promotes motor function recovery in spinal cord injured mice.
32079004	6	12	theme	nerve	1205:1209	arg1	cells					1211:1215	endogenous nerve cells	1194:1215	endogenous nerve cells	1194:1215	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	4	13	theme	injured	777:783	arg1	mice					785:788	spinal cord injured mice	765:788	spinal cord injured mice	765:788	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	6	14	theme	motor	1323:1327	arg1	function					1329:1336	motor function	1323:1336	motor function	1323:1336	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	3	15	with	scaffold	403:410	arg1	biocompatibility					427:442	excellent biocompatibility	417:442	excellent biocompatibility for cells and tissues	417:464	At present, building a neural scaffold with excellent biocompatibility for cells and tissues is still challenging.
32079004	1	16	theme	effective	260:268	arg1	treatment					270:278	no effective treatment	257:278	no effective treatment	257:278	Spinal cord injury is a devastating trauma with high mortality and disability, for which there is no effective treatment.
32079004	5	17	theme	good	827:830	arg1	cytocompatibility					832:848	a good cytocompatibility	825:848	a good cytocompatibility	825:848	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	4	18	theme	mesenchymal	699:709	arg1	BMSCs					723:727	BMSCs	723:727	BMSCs	723:727	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	4	18	theme	mesenchymal	699:709	arg1	cells					716:720	murine bone marrow-derived mesenchymal stem cells	672:720	murine bone marrow-derived mesenchymal stem cells (BMSCs)	672:728	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	4	19	theme	bone	679:682	arg1	BMSCs					723:727	BMSCs	723:727	BMSCs	723:727	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	4	19	theme	bone	679:682	arg1	cells					716:720	murine bone marrow-derived mesenchymal stem cells	672:720	murine bone marrow-derived mesenchymal stem cells (BMSCs)	672:728	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	6	20	from	recovery	1311:1318	arg1	hindlimbs					1345:1353	the hindlimbs	1341:1353	the hindlimbs of a murine spinal cord injury model	1341:1390	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	5	21	theme	hematoxylin	931:941	arg1	staining					953:960	hematoxylin and eosin staining	931:960	hematoxylin and eosin staining	931:960	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	0	22	link	marrow-derived	59:72	arg1	cells					91:95	bone marrow-derived mesenchymal stem cells	54:95	bone marrow-derived mesenchymal stem cells	54:95	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells promotes motor function recovery in spinal cord injured mice.
32079004	6	23	theme	CS-HEC-Col/GP	1124:1136	arg1	hydrogel					1138:1145	BMSC-loaded CS-HEC-Col/GP hydrogel	1112:1145	BMSC-loaded CS-HEC-Col/GP hydrogel	1112:1145	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	4	24	theme	murine	672:677	arg1	BMSCs					723:727	BMSCs	723:727	BMSCs	723:727	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	4	24	theme	murine	672:677	arg1	cells					716:720	murine bone marrow-derived mesenchymal stem cells	672:720	murine bone marrow-derived mesenchymal stem cells (BMSCs)	672:728	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	0	25	theme	chitosan-based	2:15	arg1	scaffold					33:40	A chitosan-based thermosensitive scaffold	0:40	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells	0:95	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells promotes motor function recovery in spinal cord injured mice.
32079004	6	26	theme	cells	1211:1215	arg1	survival					1165:1172	the survival	1161:1172	the survival	1161:1172	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	6	26	theme	cells	1211:1215	arg1	proliferation					1177:1189	proliferation	1177:1189	proliferation	1177:1189	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	6	27	theme	BMSC-loaded	1112:1122	arg1	hydrogel					1138:1145	BMSC-loaded CS-HEC-Col/GP hydrogel	1112:1145	BMSC-loaded CS-HEC-Col/GP hydrogel	1112:1145	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	5	28	theme	suitable	966:973	arg1	behavior					987:994	suitable rheological behavior	966:994	suitable rheological behavior similar to neural tissue	966:1019	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	1	29	theme	devastating	183:193	arg1	trauma					195:200	a devastating trauma	181:200	a devastating trauma	181:200	Spinal cord injury is a devastating trauma with high mortality and disability, for which there is no effective treatment.
32079004	1	29	theme	devastating	183:193	arg1	injury					171:176	Spinal cord injury	159:176	Spinal cord injury	159:176	Spinal cord injury is a devastating trauma with high mortality and disability, for which there is no effective treatment.
32079004	6	30	theme	model	1386:1390	arg1	hindlimbs					1345:1353	the hindlimbs	1341:1353	the hindlimbs of a murine spinal cord injury model	1341:1390	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	5	31	theme	rheological	975:985	arg1	behavior					987:994	suitable rheological behavior	966:994	suitable rheological behavior similar to neural tissue	966:1019	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	4	32	theme	marrow-derived	684:697	arg1	BMSCs					723:727	BMSCs	723:727	BMSCs	723:727	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	4	32	theme	marrow-derived	684:697	arg1	cells					716:720	murine bone marrow-derived mesenchymal stem cells	672:720	murine bone marrow-derived mesenchymal stem cells (BMSCs)	672:728	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	0	33	theme	cord	140:143	arg1	mice					153:156	spinal cord injured mice	133:156	spinal cord injured mice	133:156	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells promotes motor function recovery in spinal cord injured mice.
32079004	4	34	from	efficacy	753:760	arg1	mice					785:788	spinal cord injured mice	765:788	spinal cord injured mice	765:788	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	4	35	theme	cord	772:775	arg1	mice					785:788	spinal cord injured mice	765:788	spinal cord injured mice	765:788	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	6	36	theme	animal	1078:1083	arg1	experiments					1085:1095	animal experiments	1078:1095	animal experiments	1078:1095	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	0	37	theme	thermosensitive	17:31	arg1	scaffold					33:40	A chitosan-based thermosensitive scaffold	0:40	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells	0:95	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells promotes motor function recovery in spinal cord injured mice.
32079004	0	38	theme	spinal	133:138	arg1	cord					140:143	spinal cord	133:143	spinal cord injured mice	133:156	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells promotes motor function recovery in spinal cord injured mice.
32079004	2	39	theme	tissue	297:302	arg1	engineering					304:314	Stem cell-based tissue engineering	281:314	Stem cell-based tissue engineering	281:314	Stem cell-based tissue engineering has been reported to promote functional neural recovery.
32079004	1	40	theme	high	207:210	arg1	mortality					212:220	high mortality	207:220	high mortality	207:220	Spinal cord injury is a devastating trauma with high mortality and disability, for which there is no effective treatment.
32079004	5	41	theme	composite	796:804	arg1	hydrogel					806:813	This composite hydrogel	791:813	This composite hydrogel	791:813	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	4	42	theme	hydroxyethyl	563:574	arg1	cellulose					576:584	hydroxyethyl cellulose	563:584	hydroxyethyl cellulose	563:584	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	6	43	theme	cord	1374:1377	arg1	model					1386:1390	a murine spinal cord injury model	1358:1390	a murine spinal cord injury model	1358:1390	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	5	44	dep	Pa.	1047:1049	arg1	to					1039:1040	to	1039:1040	to	1039:1040	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	5	45	theme	live/dead	868:876	arg1	staining					878:885	live/dead staining	868:885	live/dead staining	868:885	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	3	46	theme	excellent	417:425	arg1	biocompatibility					427:442	excellent biocompatibility	417:442	excellent biocompatibility for cells and tissues	417:464	At present, building a neural scaffold with excellent biocompatibility for cells and tissues is still challenging.
32079004	0	47	theme	injured	145:151	arg1	mice					153:156	spinal cord injured mice	133:156	spinal cord injured mice	133:156	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells promotes motor function recovery in spinal cord injured mice.
32079004	4	48	link	marrow-derived	684:697	arg1	BMSCs					723:727	BMSCs	723:727	BMSCs	723:727	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	4	48	link	marrow-derived	684:697	arg1	cells					716:720	murine bone marrow-derived mesenchymal stem cells	672:720	murine bone marrow-derived mesenchymal stem cells (BMSCs)	672:728	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	0	49	theme	marrow-derived	59:72	arg1	cells					91:95	bone marrow-derived mesenchymal stem cells	54:95	bone marrow-derived mesenchymal stem cells	54:95	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells promotes motor function recovery in spinal cord injured mice.
32079004	4	50	theme	composite	525:533	arg1	hydrogel					535:542	a new thermosensitive composite hydrogel	503:542	a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel)	503:642	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	6	51	theme	murine	1360:1365	arg1	model					1386:1390	a murine spinal cord injury model	1358:1390	a murine spinal cord injury model	1358:1390	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	5	52	theme	neural	1007:1012	arg1	tissue					1014:1019	neural tissue	1007:1019	neural tissue	1007:1019	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	2	53	theme	functional	345:354	arg1	recovery					363:370	functional neural recovery	345:370	functional neural recovery	345:370	Stem cell-based tissue engineering has been reported to promote functional neural recovery.
32079004	6	54	theme	spinal	1367:1372	arg1	model					1386:1390	a murine spinal cord injury model	1358:1390	a murine spinal cord injury model	1358:1390	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	5	55	theme	inflammatory	898:909	arg1	reaction					911:918	inflammatory reaction	898:918	inflammatory reaction	898:918	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	1	56	with	trauma	195:200	arg1	disability					226:235	disability	226:235	disability	226:235	Spinal cord injury is a devastating trauma with high mortality and disability, for which there is no effective treatment.
32079004	1	56	with	trauma	195:200	arg1	mortality					212:220	high mortality	207:220	high mortality	207:220	Spinal cord injury is a devastating trauma with high mortality and disability, for which there is no effective treatment.
32079004	5	57	contain	possesses	815:823	arg2	cytocompatibility					832:848	a good cytocompatibility	825:848	a good cytocompatibility	825:848	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	5	57	contain	possesses	815:823	arg1	hydrogel					806:813	This composite hydrogel	791:813	This composite hydrogel	791:813	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	5	58	theme	eosin	947:951	arg1	staining					953:960	hematoxylin and eosin staining	931:960	hematoxylin and eosin staining	931:960	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	6	59	theme	neurotrophic	1240:1251	arg1	factors					1253:1259	neurotrophic factors	1240:1259	neurotrophic factors	1240:1259	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	0	60	from	recovery	121:128	arg1	mice					153:156	spinal cord injured mice	133:156	spinal cord injured mice	133:156	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells promotes motor function recovery in spinal cord injured mice.
32079004	4	61	theme	therapeutic	741:751	arg1	efficacy					753:760	therapeutic efficacy	741:760	therapeutic efficacy in spinal cord injured mice	741:788	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	6	62	theme	endogenous	1194:1203	arg1	cells					1211:1215	endogenous nerve cells	1194:1215	endogenous nerve cells	1194:1215	Furthermore, the data from animal experiments indicated that BMSC-loaded CS-HEC-Col/GP hydrogel could enhance the survival or proliferation of endogenous nerve cells, probably by secreting neurotrophic factors and inhibiting apoptosis, and thereby promote the recovery of motor function in the hindlimbs of a murine spinal cord injury model.
32079004	4	63	theme	stem	711:714	arg1	BMSCs					723:727	BMSCs	723:727	BMSCs	723:727	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	4	63	theme	stem	711:714	arg1	cells					716:720	murine bone marrow-derived mesenchymal stem cells	672:720	murine bone marrow-derived mesenchymal stem cells (BMSCs)	672:728	In this study, a new thermosensitive composite hydrogel based on chitosan, hydroxyethyl cellulose, collagen and β-phosphoglycerate (CS-HEC-Col/GP hydrogel) is developed to encapsulate murine bone marrow-derived mesenchymal stem cells (BMSCs) to improve therapeutic efficacy in spinal cord injured mice.
32079004	0	64	theme	stem	86:89	arg1	cells					91:95	bone marrow-derived mesenchymal stem cells	54:95	bone marrow-derived mesenchymal stem cells	54:95	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells promotes motor function recovery in spinal cord injured mice.
32079004	5	65	theme	similar	996:1002	arg1	behavior					987:994	suitable rheological behavior	966:994	suitable rheological behavior similar to neural tissue	966:1019	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	0	66	theme	mesenchymal	74:84	arg1	cells					91:95	bone marrow-derived mesenchymal stem cells	54:95	bone marrow-derived mesenchymal stem cells	54:95	A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells promotes motor function recovery in spinal cord injured mice.
32079004	5	67	theme	mouse	853:857	arg1	BMSCs					859:863	mouse BMSCs	853:863	mouse BMSCs	853:863	This composite hydrogel possesses a good cytocompatibility to mouse BMSCs by live/dead staining, minimized inflammatory reaction in vivo by hematoxylin and eosin staining and suitable rheological behavior similar to neural tissue, ranging from 100 to 1000 Pa.
32079004	1	68	theme	Spinal	159:164	arg1	trauma					195:200	a devastating trauma	181:200	a devastating trauma	181:200	Spinal cord injury is a devastating trauma with high mortality and disability, for which there is no effective treatment.
32079004	1	68	theme	Spinal	159:164	arg1	injury					171:176	Spinal cord injury	159:176	Spinal cord injury	159:176	Spinal cord injury is a devastating trauma with high mortality and disability, for which there is no effective treatment.
32027902	12	0	theme	loss	1442:1445	arg1	modulus					1452:1458	Storage (G') and loss (G″) modulus	1425:1458	Storage (G') and loss (G″) modulus	1425:1458	Storage (G') and loss (G″) modulus were increased by the nanoparticles and reduced by the meloxicam solution.
32027902	11	1	theme	wave	1292:1295	arg1	numbers					1297:1303	the lower wave numbers	1282:1303	the lower wave numbers	1282:1303	The ATR-FTIR bands were shifted to the lower wave numbers in the hydrogels containing nanoparticles and shifted to the upper ones in the hydrogels containing meloxicam solution.
32027902	9	2	theme	degradation	1059:1069	arg1	rate					1071:1074	the degradation rate	1055:1074	the degradation rate of the hydrogels	1055:1091	Gelation time, swelling and the degradation rate of the hydrogels were found to be decreased by nanoparticles and increased with the addition of the meloxicam solution.
32027902	10	3	theme	three-dimensional	1219:1235	arg1	networks					1237:1244	three-dimensional networks	1219:1244	three-dimensional networks	1219:1244	SEM images also showed three-dimensional networks.
32027902	8	4	from	growth	984:989	arg1	hydrogels					998:1006	the hydrogels	994:1006	the hydrogels	994:1006	Meloxicam release, chondrocytes attachment and growth on the hydrogels were also studied.
32027902	15	5	theme	containing	1816:1825	arg1	nanoparticles					1827:1839	Hydrogel containing nanoparticles	1807:1839	Hydrogel containing nanoparticles	1807:1839	Hydrogel containing nanoparticles showed good biocompatibility, bioadhesion, cell growth and expansion.
32027902	5	6	theme	meloxicam	648:656	arg1	solution					658:665	the meloxicam solution	644:665	the meloxicam solution	644:665	Hydrogels containing the same amounts of the meloxicam solution were also prepared.
32027902	9	7	theme	meloxicam	1176:1184	arg1	solution					1186:1193	the meloxicam solution	1172:1193	the meloxicam solution	1172:1193	Gelation time, swelling and the degradation rate of the hydrogels were found to be decreased by nanoparticles and increased with the addition of the meloxicam solution.
32027902	14	8	theme	Chondrocytes	1717:1728	arg1	activity					1740:1747	Chondrocytes metabolic activity	1717:1747	Chondrocytes metabolic activity	1717:1747	Chondrocytes metabolic activity was increased on the 6th and 10th days for all hydrogels.
32027902	3	9	theme	chitosan	385:392	arg1	hydrogels					452:460	carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels	371:460	carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles	371:507	In the present study, carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles were developed and characterized.
32027902	5	10	theme	solution	658:665	arg1	amounts					633:639	the same amounts	624:639	the same amounts of the meloxicam solution	624:665	Hydrogels containing the same amounts of the meloxicam solution were also prepared.
32027902	5	10	theme	solution	658:665	arg1	solution					658:665	the meloxicam solution	644:665	the meloxicam solution	644:665	Hydrogels containing the same amounts of the meloxicam solution were also prepared.
32027902	9	11	theme	solution	1186:1193	arg1	addition					1160:1167	the addition	1156:1167	the addition of the meloxicam solution	1156:1193	Gelation time, swelling and the degradation rate of the hydrogels were found to be decreased by nanoparticles and increased with the addition of the meloxicam solution.
32027902	16	12	theme	new	1959:1961	arg1	biomaterial					1973:1983	a new composite biomaterial	1957:1983	a new composite biomaterial for the regeneration of articular cartilage and meloxicam delivery to control the pain and inflammation in osteoarthritis	1957:2105	The hydrogel could be, therefore, suitable as a new composite biomaterial for the regeneration of articular cartilage and meloxicam delivery to control the pain and inflammation in osteoarthritis.
32027902	7	13	theme	ATR-FTIR	887:894	arg1	spectroscopy					897:908	infrared (ATR-FTIR) spectroscopy	877:908	infrared (ATR-FTIR) spectroscopy	877:908	Hydrogels were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, and rheological analysis.
32027902	11	14	theme	lower	1286:1290	arg1	numbers					1297:1303	the lower wave numbers	1282:1303	the lower wave numbers	1282:1303	The ATR-FTIR bands were shifted to the lower wave numbers in the hydrogels containing nanoparticles and shifted to the upper ones in the hydrogels containing meloxicam solution.
32027902	15	15	theme	Hydrogel	1807:1814	arg1	nanoparticles					1827:1839	Hydrogel containing nanoparticles	1807:1839	Hydrogel containing nanoparticles	1807:1839	Hydrogel containing nanoparticles showed good biocompatibility, bioadhesion, cell growth and expansion.
32027902	2	16	theme	side	315:318	arg1	effects					320:326	less adverse side effects	302:326	less adverse side effects	302:326	Specific drug delivery to the tissues ensures less adverse side effects and more efficiency.
32027902	11	17	theme	upper	1366:1370	arg1	ones					1372:1375	the upper ones	1362:1375	the upper ones	1362:1375	The ATR-FTIR bands were shifted to the lower wave numbers in the hydrogels containing nanoparticles and shifted to the upper ones in the hydrogels containing meloxicam solution.
32027902	12	18	theme	meloxicam	1515:1523	arg1	solution					1525:1532	the meloxicam solution	1511:1532	the meloxicam solution	1511:1532	Storage (G') and loss (G″) modulus were increased by the nanoparticles and reduced by the meloxicam solution.
32027902	16	19	from	pain	2067:2070	arg1	osteoarthritis					2092:2105	osteoarthritis	2092:2105	osteoarthritis	2092:2105	The hydrogel could be, therefore, suitable as a new composite biomaterial for the regeneration of articular cartilage and meloxicam delivery to control the pain and inflammation in osteoarthritis.
32027902	13	20	attach	released	1646:1653	arg2	it					1639:1640	it	1639:1640	it	1639:1640	100% of meloxicam was released from the hydrogels containing the meloxicam solution within 20 days, but it was released slowly from the hydrogels containing nanoparticles in 37days.
32027902	13	20	attach	released	1646:1653	arg1	hydrogels					1671:1679	the hydrogels	1667:1679	the hydrogels containing nanoparticles in 37days	1667:1714	100% of meloxicam was released from the hydrogels containing the meloxicam solution within 20 days, but it was released slowly from the hydrogels containing nanoparticles in 37days.
32027902	2	21	theme	adverse	307:313	arg1	effects					320:326	less adverse side effects	302:326	less adverse side effects	302:326	Specific drug delivery to the tissues ensures less adverse side effects and more efficiency.
32027902	7	22	theme	infrared	877:884	arg1	spectroscopy					897:908	infrared (ATR-FTIR) spectroscopy	877:908	infrared (ATR-FTIR) spectroscopy	877:908	Hydrogels were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, and rheological analysis.
32027902	5	23	contain	containing	613:622	arg2	solution					658:665	the meloxicam solution	644:665	the meloxicam solution	644:665	Hydrogels containing the same amounts of the meloxicam solution were also prepared.
32027902	5	23	contain	containing	613:622	arg1	Hydrogels					603:611	Hydrogels	603:611	Hydrogels containing the same amounts of the meloxicam solution	603:665	Hydrogels containing the same amounts of the meloxicam solution were also prepared.
32027902	5	23	contain	containing	613:622	arg2	amounts					633:639	the same amounts	624:639	the same amounts of the meloxicam solution	624:665	Hydrogels containing the same amounts of the meloxicam solution were also prepared.
32027902	3	24	theme	carboxymethyl	371:383	arg1	CMC					395:397	CMC	395:397	CMC	395:397	In the present study, carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles were developed and characterized.
32027902	3	24	theme	carboxymethyl	371:383	arg1	chitosan					385:392	carboxymethyl chitosan	371:392	carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P)	371:432	In the present study, carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles were developed and characterized.
32027902	15	25	theme	cell	1884:1887	arg1	growth					1889:1894	cell growth	1884:1894	cell growth	1884:1894	Hydrogel containing nanoparticles showed good biocompatibility, bioadhesion, cell growth and expansion.
32027902	5	26	theme	same	628:631	arg1	amounts					633:639	the same amounts	624:639	the same amounts of the meloxicam solution	624:665	Hydrogels containing the same amounts of the meloxicam solution were also prepared.
32027902	5	26	theme	same	628:631	arg1	solution					658:665	the meloxicam solution	644:665	the meloxicam solution	644:665	Hydrogels containing the same amounts of the meloxicam solution were also prepared.
32027902	12	27	theme	Storage	1425:1431	arg1	modulus					1452:1458	Storage (G') and loss (G″) modulus	1425:1458	Storage (G') and loss (G″) modulus	1425:1458	Storage (G') and loss (G″) modulus were increased by the nanoparticles and reduced by the meloxicam solution.
32027902	7	28	theme	reflection	848:857	arg1	Fourier					859:865	attenuated total reflection Fourier	831:865	attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy	831:908	Hydrogels were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, and rheological analysis.
32027902	3	29	theme	zinc	438:441	arg1	chloride					443:450	zinc chloride	438:450	zinc chloride	438:450	In the present study, carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles were developed and characterized.
32027902	0	30	theme	injectable	3:12	arg1	hydrogel					62:69	An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel	0:69	An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel for the encapsulation of meloxicam loaded	0:111	An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel for the encapsulation of meloxicam loaded nanoparticles.
32027902	15	31	theme	good	1848:1851	arg1	biocompatibility					1853:1868	good biocompatibility	1848:1868	good biocompatibility	1848:1868	Hydrogel containing nanoparticles showed good biocompatibility, bioadhesion, cell growth and expansion.
32027902	3	32	dep	-pluronic	420:428	arg1	P					431:431	P	431:431	P	431:431	In the present study, carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles were developed and characterized.
32027902	3	33	theme	present	356:362	arg1	study					364:368	the present study	352:368	the present study	352:368	In the present study, carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles were developed and characterized.
32027902	13	34	theme	meloxicam	1543:1551	arg1	meloxicam					1543:1551	meloxicam	1543:1551	meloxicam	1543:1551	100% of meloxicam was released from the hydrogels containing the meloxicam solution within 20 days, but it was released slowly from the hydrogels containing nanoparticles in 37days.
32027902	13	34	theme	meloxicam	1543:1551	arg1	%					1538:1538	100%	1535:1538	100% of meloxicam	1535:1551	100% of meloxicam was released from the hydrogels containing the meloxicam solution within 20 days, but it was released slowly from the hydrogels containing nanoparticles in 37days.
32027902	11	35	contain	containing	1322:1331	arg2	nanoparticles					1333:1345	nanoparticles	1333:1345	nanoparticles	1333:1345	The ATR-FTIR bands were shifted to the lower wave numbers in the hydrogels containing nanoparticles and shifted to the upper ones in the hydrogels containing meloxicam solution.
32027902	11	35	contain	containing	1322:1331	arg1	hydrogels					1312:1320	the hydrogels	1308:1320	the hydrogels containing nanoparticles	1308:1345	The ATR-FTIR bands were shifted to the lower wave numbers in the hydrogels containing nanoparticles and shifted to the upper ones in the hydrogels containing meloxicam solution.
32027902	13	36	contain	containing	1585:1594	arg1	hydrogels					1575:1583	the hydrogels	1571:1583	the hydrogels containing the meloxicam solution within 20 days	1571:1632	100% of meloxicam was released from the hydrogels containing the meloxicam solution within 20 days, but it was released slowly from the hydrogels containing nanoparticles in 37days.
32027902	13	36	contain	containing	1585:1594	arg2	solution					1610:1617	the meloxicam solution	1596:1617	the meloxicam solution	1596:1617	100% of meloxicam was released from the hydrogels containing the meloxicam solution within 20 days, but it was released slowly from the hydrogels containing nanoparticles in 37days.
32027902	16	37	dep	pain	2067:2070	arg1	the					2063:2065	the	2063:2065	the	2063:2065	The hydrogel could be, therefore, suitable as a new composite biomaterial for the regeneration of articular cartilage and meloxicam delivery to control the pain and inflammation in osteoarthritis.
32027902	1	38	theme	Hydrogel	128:135	arg1	scaffolds					137:145	Hydrogel scaffolds	128:145	Hydrogel scaffolds	128:145	Hydrogel scaffolds have been frequently utilized due to their ability to absorb water and develop similar body cell conditions.
32027902	6	39	theme	Gelation	687:694	arg1	time					696:699	Gelation time	687:699	Gelation time	687:699	Gelation time, swelling and degradation of the hydrogels were investigated.
32027902	0	40	theme	chitosan-methylcellulose-pluronic	28:60	arg1	hydrogel					62:69	An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel	0:69	An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel for the encapsulation of meloxicam loaded	0:111	An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel for the encapsulation of meloxicam loaded nanoparticles.
32027902	16	41	from	inflammation	2076:2087	arg1	osteoarthritis					2092:2105	osteoarthritis	2092:2105	osteoarthritis	2092:2105	The hydrogel could be, therefore, suitable as a new composite biomaterial for the regeneration of articular cartilage and meloxicam delivery to control the pain and inflammation in osteoarthritis.
32027902	16	42	theme	cartilage	2019:2027	arg1	meloxicam					2033:2041	meloxicam	2033:2041	meloxicam	2033:2041	The hydrogel could be, therefore, suitable as a new composite biomaterial for the regeneration of articular cartilage and meloxicam delivery to control the pain and inflammation in osteoarthritis.
32027902	16	42	theme	cartilage	2019:2027	arg1	regeneration					1993:2004	the regeneration	1989:2004	the regeneration of articular cartilage	1989:2027	The hydrogel could be, therefore, suitable as a new composite biomaterial for the regeneration of articular cartilage and meloxicam delivery to control the pain and inflammation in osteoarthritis.
32027902	7	43	theme	attenuated	831:840	arg1	Fourier					859:865	attenuated total reflection Fourier	831:865	attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy	831:908	Hydrogels were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, and rheological analysis.
32027902	8	44	from	attachment	969:978	arg1	hydrogels					998:1006	the hydrogels	994:1006	the hydrogels	994:1006	Meloxicam release, chondrocytes attachment and growth on the hydrogels were also studied.
32027902	7	45	theme	total	842:846	arg1	Fourier					859:865	attenuated total reflection Fourier	831:865	attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy	831:908	Hydrogels were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, and rheological analysis.
32027902	1	46	theme	similar	226:232	arg1	conditions					244:253	similar body cell conditions	226:253	similar body cell conditions	226:253	Hydrogel scaffolds have been frequently utilized due to their ability to absorb water and develop similar body cell conditions.
32027902	1	47	used	utilized	168:175	arg2	scaffolds					137:145	Hydrogel scaffolds	128:145	Hydrogel scaffolds	128:145	Hydrogel scaffolds have been frequently utilized due to their ability to absorb water and develop similar body cell conditions.
32027902	7	48	theme	electron	804:811	arg1	microscopy					813:822	scanning electron microscopy	795:822	scanning electron microscopy (SEM)	795:828	Hydrogels were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, and rheological analysis.
32027902	7	48	theme	electron	804:811	arg1	SEM					825:827	SEM	825:827	SEM	825:827	Hydrogels were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, and rheological analysis.
32027902	11	49	theme	ATR-FTIR	1251:1258	arg1	bands					1260:1264	The ATR-FTIR bands	1247:1264	The ATR-FTIR bands	1247:1264	The ATR-FTIR bands were shifted to the lower wave numbers in the hydrogels containing nanoparticles and shifted to the upper ones in the hydrogels containing meloxicam solution.
32027902	11	50	contain	containing	1394:1403	arg1	hydrogels					1384:1392	the hydrogels	1380:1392	the hydrogels containing meloxicam solution	1380:1422	The ATR-FTIR bands were shifted to the lower wave numbers in the hydrogels containing nanoparticles and shifted to the upper ones in the hydrogels containing meloxicam solution.
32027902	11	50	contain	containing	1394:1403	arg2	solution					1415:1422	meloxicam solution	1405:1422	meloxicam solution	1405:1422	The ATR-FTIR bands were shifted to the lower wave numbers in the hydrogels containing nanoparticles and shifted to the upper ones in the hydrogels containing meloxicam solution.
32027902	1	51	theme	body	234:237	arg1	conditions					244:253	similar body cell conditions	226:253	similar body cell conditions	226:253	Hydrogel scaffolds have been frequently utilized due to their ability to absorb water and develop similar body cell conditions.
32027902	3	52	theme	-pluronic	420:428	arg1	CMC					395:397	CMC	395:397	CMC	395:397	In the present study, carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles were developed and characterized.
32027902	3	52	theme	-pluronic	420:428	arg1	chitosan					385:392	carboxymethyl chitosan	371:392	carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P)	371:432	In the present study, carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles were developed and characterized.
32027902	9	53	theme	hydrogels	1083:1091	arg1	swelling					1042:1049	swelling	1042:1049	swelling	1042:1049	Gelation time, swelling and the degradation rate of the hydrogels were found to be decreased by nanoparticles and increased with the addition of the meloxicam solution.
32027902	9	53	theme	hydrogels	1083:1091	arg1	time					1036:1039	Gelation time	1027:1039	Gelation time	1027:1039	Gelation time, swelling and the degradation rate of the hydrogels were found to be decreased by nanoparticles and increased with the addition of the meloxicam solution.
32027902	9	53	theme	hydrogels	1083:1091	arg1	rate					1071:1074	the degradation rate	1055:1074	the degradation rate of the hydrogels	1055:1091	Gelation time, swelling and the degradation rate of the hydrogels were found to be decreased by nanoparticles and increased with the addition of the meloxicam solution.
32027902	1	54	theme	cell	239:242	arg1	conditions					244:253	similar body cell conditions	226:253	similar body cell conditions	226:253	Hydrogel scaffolds have been frequently utilized due to their ability to absorb water and develop similar body cell conditions.
32027902	3	55	theme	chloride	443:450	arg1	hydrogels					452:460	carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels	371:460	carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles	371:507	In the present study, carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles were developed and characterized.
32027902	14	56	theme	10th	1778:1781	arg1	days					1783:1786	the 6th and 10th days	1766:1786	the 6th and 10th days for all hydrogels	1766:1804	Chondrocytes metabolic activity was increased on the 6th and 10th days for all hydrogels.
32027902	16	57	theme	articular	2009:2017	arg1	cartilage					2019:2027	articular cartilage	2009:2027	articular cartilage	2009:2027	The hydrogel could be, therefore, suitable as a new composite biomaterial for the regeneration of articular cartilage and meloxicam delivery to control the pain and inflammation in osteoarthritis.
32027902	2	58	theme	drug	265:268	arg1	delivery					270:277	Specific drug delivery	256:277	Specific drug delivery to the tissues	256:292	Specific drug delivery to the tissues ensures less adverse side effects and more efficiency.
32027902	8	59	theme	Meloxicam	937:945	arg1	release					947:953	Meloxicam release	937:953	Meloxicam release	937:953	Meloxicam release, chondrocytes attachment and growth on the hydrogels were also studied.
32027902	13	60	attach	released	1557:1564	arg1	hydrogels					1575:1583	the hydrogels	1571:1583	the hydrogels containing the meloxicam solution within 20 days	1571:1632	100% of meloxicam was released from the hydrogels containing the meloxicam solution within 20 days, but it was released slowly from the hydrogels containing nanoparticles in 37days.
32027902	13	60	attach	released	1557:1564	arg2	%					1538:1538	100%	1535:1538	100% of meloxicam	1535:1551	100% of meloxicam was released from the hydrogels containing the meloxicam solution within 20 days, but it was released slowly from the hydrogels containing nanoparticles in 37days.
32027902	13	60	attach	released	1557:1564	arg2	meloxicam					1543:1551	meloxicam	1543:1551	meloxicam	1543:1551	100% of meloxicam was released from the hydrogels containing the meloxicam solution within 20 days, but it was released slowly from the hydrogels containing nanoparticles in 37days.
32027902	7	61	theme	scanning	795:802	arg1	microscopy					813:822	scanning electron microscopy	795:822	scanning electron microscopy (SEM)	795:828	Hydrogels were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, and rheological analysis.
32027902	7	61	theme	scanning	795:802	arg1	SEM					825:827	SEM	825:827	SEM	825:827	Hydrogels were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, and rheological analysis.
32027902	13	62	theme	meloxicam	1600:1608	arg1	solution					1610:1617	the meloxicam solution	1596:1617	the meloxicam solution	1596:1617	100% of meloxicam was released from the hydrogels containing the meloxicam solution within 20 days, but it was released slowly from the hydrogels containing nanoparticles in 37days.
32027902	3	63	contain	containing	462:471	arg2	meloxicam					473:481	meloxicam	473:481	meloxicam loaded into nanoparticles	473:507	In the present study, carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles were developed and characterized.
32027902	3	63	contain	containing	462:471	arg1	hydrogels					452:460	carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels	371:460	carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles	371:507	In the present study, carboxymethyl chitosan (CMC)-methylcellulose (MC)-pluronic (P) and zinc chloride hydrogels containing meloxicam loaded into nanoparticles were developed and characterized.
32027902	2	64	theme	Specific	256:263	arg1	delivery					270:277	Specific drug delivery	256:277	Specific drug delivery to the tissues	256:292	Specific drug delivery to the tissues ensures less adverse side effects and more efficiency.
32027902	7	65	dep	Fourier	859:865	arg1	transform					867:875	transform	867:875	transform infrared (ATR-FTIR) spectroscopy	867:908	Hydrogels were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, and rheological analysis.
32027902	9	66	theme	Gelation	1027:1034	arg1	time					1036:1039	Gelation time	1027:1039	Gelation time	1027:1039	Gelation time, swelling and the degradation rate of the hydrogels were found to be decreased by nanoparticles and increased with the addition of the meloxicam solution.
32027902	14	67	theme	6th	1770:1772	arg1	days					1783:1786	the 6th and 10th days	1766:1786	the 6th and 10th days for all hydrogels	1766:1804	Chondrocytes metabolic activity was increased on the 6th and 10th days for all hydrogels.
32027902	14	68	theme	metabolic	1730:1738	arg1	activity					1740:1747	Chondrocytes metabolic activity	1717:1747	Chondrocytes metabolic activity	1717:1747	Chondrocytes metabolic activity was increased on the 6th and 10th days for all hydrogels.
32027902	7	69	theme	rheological	915:925	arg1	analysis					927:934	rheological analysis	915:934	rheological analysis	915:934	Hydrogels were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, and rheological analysis.
32027902	13	70	contain	containing	1681:1690	arg2	nanoparticles					1692:1704	nanoparticles	1692:1704	nanoparticles	1692:1704	100% of meloxicam was released from the hydrogels containing the meloxicam solution within 20 days, but it was released slowly from the hydrogels containing nanoparticles in 37days.
32027902	13	70	contain	containing	1681:1690	arg1	hydrogels					1671:1679	the hydrogels	1667:1679	the hydrogels containing nanoparticles in 37days	1667:1714	100% of meloxicam was released from the hydrogels containing the meloxicam solution within 20 days, but it was released slowly from the hydrogels containing nanoparticles in 37days.
32027902	10	71	theme	SEM	1196:1198	arg1	images					1200:1205	SEM images	1196:1205	SEM images	1196:1205	SEM images also showed three-dimensional networks.
32027902	16	72	theme	composite	1963:1971	arg1	biomaterial					1973:1983	a new composite biomaterial	1957:1983	a new composite biomaterial for the regeneration of articular cartilage and meloxicam delivery to control the pain and inflammation in osteoarthritis	1957:2105	The hydrogel could be, therefore, suitable as a new composite biomaterial for the regeneration of articular cartilage and meloxicam delivery to control the pain and inflammation in osteoarthritis.
32027902	16	73	dep	regeneration	1993:2004	arg1	delivery					2043:2050	delivery	2043:2050	delivery	2043:2050	The hydrogel could be, therefore, suitable as a new composite biomaterial for the regeneration of articular cartilage and meloxicam delivery to control the pain and inflammation in osteoarthritis.
32027902	6	74	theme	hydrogels	734:742	arg1	degradation					715:725	degradation	715:725	degradation	715:725	Gelation time, swelling and degradation of the hydrogels were investigated.
32027902	6	74	theme	hydrogels	734:742	arg1	swelling					702:709	swelling	702:709	swelling	702:709	Gelation time, swelling and degradation of the hydrogels were investigated.
32027902	6	74	theme	hydrogels	734:742	arg1	time					696:699	Gelation time	687:699	Gelation time	687:699	Gelation time, swelling and degradation of the hydrogels were investigated.
32027902	2	75	dep	efficiency	337:346	arg1	more					332:335	more	332:335	more	332:335	Specific drug delivery to the tissues ensures less adverse side effects and more efficiency.
32027902	0	76	theme	meloxicam	96:104	arg1	encapsulation					79:91	the encapsulation	75:91	the encapsulation of meloxicam loaded	75:111	An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel for the encapsulation of meloxicam loaded nanoparticles.
32027902	8	77	theme	chondrocytes	956:967	arg1	attachment					969:978	chondrocytes attachment	956:978	chondrocytes attachment	956:978	Meloxicam release, chondrocytes attachment and growth on the hydrogels were also studied.
32027902	8	78	from	release	947:953	arg1	hydrogels					998:1006	the hydrogels	994:1006	the hydrogels	994:1006	Meloxicam release, chondrocytes attachment and growth on the hydrogels were also studied.
32027902	11	79	theme	meloxicam	1405:1413	arg1	solution					1415:1422	meloxicam solution	1405:1422	meloxicam solution	1405:1422	The ATR-FTIR bands were shifted to the lower wave numbers in the hydrogels containing nanoparticles and shifted to the upper ones in the hydrogels containing meloxicam solution.
32027902	0	80	theme	carboxymethyl	14:26	arg1	hydrogel					62:69	An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel	0:69	An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel for the encapsulation of meloxicam loaded	0:111	An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel for the encapsulation of meloxicam loaded nanoparticles.
32061851	0	0	theme	membranes	100:108	arg1	properties					52:61	mechanical and antibacterial properties	23:61	mechanical and antibacterial properties of cellulose acetate ultrafiltration membranes	23:108	Enhanced permeability, mechanical and antibacterial properties of cellulose acetate ultrafiltration membranes incorporated with lignocellulose nanofibrils.
32061851	5	1	theme	%	943:943	arg1	membranes					1018:1026	ultrafiltration membranes	1002:1026	ultrafiltration membranes	1002:1026	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	1	theme	%	943:943	arg1	strain-at-break					919:933	strain-at-break	919:933	strain-at-break of 12.21%	919:943	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	1	theme	%	943:943	arg1	strength					894:901	high tensile strength	881:901	high tensile strength of 7.08 MPa	881:913	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	1	theme	%	943:943	arg1	permeability					966:977	high filtration permeability	950:977	high filtration permeability of 188.23 L·m-2·h-1	950:997	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	4	2	theme	acid	736:739	arg1	hydrolysis					741:750	acid hydrolysis	736:750	acid hydrolysis	736:750	LCNFs was prepared by using a combined method of one-step chemical pretreatment and acid hydrolysis coupled with high-pressure homogenization.
32061851	1	3	theme	ultrafiltration	179:193	arg1	membranes					195:203	Cellulose acetate (CA) ultrafiltration membranes	156:203	Cellulose acetate (CA) ultrafiltration membranes	156:203	Cellulose acetate (CA) ultrafiltration membranes are attracting more attention in wastewater purification due to its biodegradability and eco-friendly.
32061851	5	4	theme	as-prepared	799:809	arg1	membranes					830:838	The as-prepared CA/LCNFs composite membranes	795:838	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs	795:869	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	0	5	theme	ultrafiltration	84:98	arg1	membranes					100:108	cellulose acetate ultrafiltration membranes	66:108	cellulose acetate ultrafiltration membranes	66:108	Enhanced permeability, mechanical and antibacterial properties of cellulose acetate ultrafiltration membranes incorporated with lignocellulose nanofibrils.
32061851	2	6	theme	bacterial	387:395	arg1	corrosion					397:405	bacterial corrosion	387:405	bacterial corrosion	387:405	The application of CA membranes, however, is limited by high susceptibility to bacterial corrosion and lack of mechanical tolerance that results in loss of life.
32061851	3	7	theme	lignocellulose	583:596	arg1	LCNFs					611:615	LCNFs	611:615	LCNFs	611:615	To solve the above problems, we first fabricated the CA-based composite membranes incorporated with bamboo-based lignocellulose nanofibrils (LCNFs) by a strategy of phase inversion.
32061851	3	7	theme	lignocellulose	583:596	arg1	nanofibrils					598:608	bamboo-based lignocellulose nanofibrils	570:608	bamboo-based lignocellulose nanofibrils (LCNFs)	570:616	To solve the above problems, we first fabricated the CA-based composite membranes incorporated with bamboo-based lignocellulose nanofibrils (LCNFs) by a strategy of phase inversion.
32061851	2	8	theme	membranes	330:338	arg1	application					312:322	The application	308:322	The application of CA membranes	308:338	The application of CA membranes, however, is limited by high susceptibility to bacterial corrosion and lack of mechanical tolerance that results in loss of life.
32061851	2	9	theme	CA	327:328	arg1	membranes					330:338	CA membranes	327:338	CA membranes	327:338	The application of CA membranes, however, is limited by high susceptibility to bacterial corrosion and lack of mechanical tolerance that results in loss of life.
32061851	2	10	theme	mechanical	419:428	arg1	tolerance					430:438	mechanical tolerance	419:438	mechanical tolerance that results in loss of life	419:467	The application of CA membranes, however, is limited by high susceptibility to bacterial corrosion and lack of mechanical tolerance that results in loss of life.
32061851	0	11	theme	lignocellulose	128:141	arg1	nanofibrils					143:153	lignocellulose nanofibrils	128:153	lignocellulose nanofibrils	128:153	Enhanced permeability, mechanical and antibacterial properties of cellulose acetate ultrafiltration membranes incorporated with lignocellulose nanofibrils.
32061851	5	12	theme	high	950:953	arg1	membranes					1018:1026	ultrafiltration membranes	1002:1026	ultrafiltration membranes	1002:1026	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	12	theme	high	950:953	arg1	permeability					966:977	high filtration permeability	950:977	high filtration permeability of 188.23 L·m-2·h-1	950:997	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	12	theme	high	950:953	arg1	strength					894:901	high tensile strength	881:901	high tensile strength of 7.08 MPa	881:913	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	12	theme	high	950:953	arg1	strain-at-break					919:933	strain-at-break	919:933	strain-at-break of 12.21%	919:943	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	13	theme	4 wt	845:848	arg1	lignin					851:856	4 wt% lignin	845:856	4 wt% lignin in the LCNFs	845:869	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	3	14	theme	bamboo-based	570:581	arg1	LCNFs					611:615	LCNFs	611:615	LCNFs	611:615	To solve the above problems, we first fabricated the CA-based composite membranes incorporated with bamboo-based lignocellulose nanofibrils (LCNFs) by a strategy of phase inversion.
32061851	3	14	theme	bamboo-based	570:581	arg1	nanofibrils					598:608	bamboo-based lignocellulose nanofibrils	570:608	bamboo-based lignocellulose nanofibrils (LCNFs)	570:616	To solve the above problems, we first fabricated the CA-based composite membranes incorporated with bamboo-based lignocellulose nanofibrils (LCNFs) by a strategy of phase inversion.
32061851	2	15	theme	tolerance	430:438	arg1	susceptibility					369:382	high susceptibility	364:382	high susceptibility to bacterial corrosion	364:405	The application of CA membranes, however, is limited by high susceptibility to bacterial corrosion and lack of mechanical tolerance that results in loss of life.
32061851	2	15	theme	tolerance	430:438	arg1	lack					411:414	lack	411:414	lack of mechanical tolerance that results in loss of life	411:467	The application of CA membranes, however, is limited by high susceptibility to bacterial corrosion and lack of mechanical tolerance that results in loss of life.
32061851	5	16	theme	CA/LCNFs	811:818	arg1	membranes					830:838	The as-prepared CA/LCNFs composite membranes	795:838	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs	795:869	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	1	17	theme	more	220:223	arg1	attention					225:233	more attention	220:233	more attention	220:233	Cellulose acetate (CA) ultrafiltration membranes are attracting more attention in wastewater purification due to its biodegradability and eco-friendly.
32061851	0	18	theme	Enhanced	0:7	arg1	permeability					9:20	Enhanced permeability	0:20	Enhanced permeability	0:20	Enhanced permeability, mechanical and antibacterial properties of cellulose acetate ultrafiltration membranes incorporated with lignocellulose nanofibrils.
32061851	5	19	theme	ultrafiltration	1002:1016	arg1	membranes					1018:1026	ultrafiltration membranes	1002:1026	ultrafiltration membranes	1002:1026	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	19	theme	ultrafiltration	1002:1016	arg1	strain-at-break					919:933	strain-at-break	919:933	strain-at-break of 12.21%	919:943	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	19	theme	ultrafiltration	1002:1016	arg1	strength					894:901	high tensile strength	881:901	high tensile strength of 7.08 MPa	881:913	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	19	theme	ultrafiltration	1002:1016	arg1	permeability					966:977	high filtration permeability	950:977	high filtration permeability of 188.23 L·m-2·h-1	950:997	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	0	20	theme	mechanical	23:32	arg1	properties					52:61	mechanical and antibacterial properties	23:61	mechanical and antibacterial properties of cellulose acetate ultrafiltration membranes	23:108	Enhanced permeability, mechanical and antibacterial properties of cellulose acetate ultrafiltration membranes incorporated with lignocellulose nanofibrils.
32061851	5	21	theme	wastewater	1032:1041	arg1	treatment					1043:1051	wastewater treatment	1032:1051	wastewater treatment	1032:1051	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	2	22	theme	life	464:467	arg1	loss					456:459	loss	456:459	loss of life	456:467	The application of CA membranes, however, is limited by high susceptibility to bacterial corrosion and lack of mechanical tolerance that results in loss of life.
32061851	3	23	theme	composite	532:540	arg1	membranes					542:550	the CA-based composite membranes	519:550	the CA-based composite membranes incorporated with bamboo-based lignocellulose nanofibrils (LCNFs)	519:616	To solve the above problems, we first fabricated the CA-based composite membranes incorporated with bamboo-based lignocellulose nanofibrils (LCNFs) by a strategy of phase inversion.
32061851	1	24	theme	wastewater	238:247	arg1	purification					249:260	wastewater purification	238:260	wastewater purification due to its biodegradability and eco-friendly	238:305	Cellulose acetate (CA) ultrafiltration membranes are attracting more attention in wastewater purification due to its biodegradability and eco-friendly.
32061851	0	25	theme	antibacterial	38:50	arg1	properties					52:61	mechanical and antibacterial properties	23:61	mechanical and antibacterial properties of cellulose acetate ultrafiltration membranes	23:108	Enhanced permeability, mechanical and antibacterial properties of cellulose acetate ultrafiltration membranes incorporated with lignocellulose nanofibrils.
32061851	4	26	theme	hydrolysis	741:750	arg1	method					691:696	a combined method	680:696	a combined method of one-step chemical pretreatment and acid hydrolysis coupled with high-pressure homogenization	680:792	LCNFs was prepared by using a combined method of one-step chemical pretreatment and acid hydrolysis coupled with high-pressure homogenization.
32061851	4	27	theme	one-step	701:708	arg1	pretreatment					719:730	one-step chemical pretreatment	701:730	one-step chemical pretreatment	701:730	LCNFs was prepared by using a combined method of one-step chemical pretreatment and acid hydrolysis coupled with high-pressure homogenization.
32061851	5	28	theme	%	849:849	arg1	lignin					851:856	4 wt% lignin	845:856	4 wt% lignin in the LCNFs	845:869	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	3	29	theme	phase	635:639	arg1	inversion					641:649	phase inversion	635:649	phase inversion	635:649	To solve the above problems, we first fabricated the CA-based composite membranes incorporated with bamboo-based lignocellulose nanofibrils (LCNFs) by a strategy of phase inversion.
32061851	3	30	theme	above	483:487	arg1	problems					489:496	the above problems	479:496	the above problems	479:496	To solve the above problems, we first fabricated the CA-based composite membranes incorporated with bamboo-based lignocellulose nanofibrils (LCNFs) by a strategy of phase inversion.
32061851	3	31	theme	CA-based	523:530	arg1	membranes					542:550	the CA-based composite membranes	519:550	the CA-based composite membranes incorporated with bamboo-based lignocellulose nanofibrils (LCNFs)	519:616	To solve the above problems, we first fabricated the CA-based composite membranes incorporated with bamboo-based lignocellulose nanofibrils (LCNFs) by a strategy of phase inversion.
32061851	5	32	theme	composite	820:828	arg1	membranes					830:838	The as-prepared CA/LCNFs composite membranes	795:838	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs	795:869	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	33	theme	filtration	955:964	arg1	membranes					1018:1026	ultrafiltration membranes	1002:1026	ultrafiltration membranes	1002:1026	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	33	theme	filtration	955:964	arg1	permeability					966:977	high filtration permeability	950:977	high filtration permeability of 188.23 L·m-2·h-1	950:997	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	33	theme	filtration	955:964	arg1	strength					894:901	high tensile strength	881:901	high tensile strength of 7.08 MPa	881:913	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	33	theme	filtration	955:964	arg1	strain-at-break					919:933	strain-at-break	919:933	strain-at-break of 12.21%	919:943	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	34	theme	coli	1110:1113	arg1	growth					1088:1093	the growth	1084:1093	the growth of Escherichia coli	1084:1113	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	1	35	theme	Cellulose	156:164	arg1	acetate					166:172	Cellulose acetate	156:172	Cellulose acetate (CA) ultrafiltration membranes	156:203	Cellulose acetate (CA) ultrafiltration membranes are attracting more attention in wastewater purification due to its biodegradability and eco-friendly.
32061851	1	35	theme	Cellulose	156:164	arg1	CA					175:176	CA	175:176	CA	175:176	Cellulose acetate (CA) ultrafiltration membranes are attracting more attention in wastewater purification due to its biodegradability and eco-friendly.
32061851	5	36	with	membranes	830:838	arg1	lignin					851:856	4 wt% lignin	845:856	4 wt% lignin in the LCNFs	845:869	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	1	37	theme	acetate	166:172	arg1	membranes					195:203	Cellulose acetate (CA) ultrafiltration membranes	156:203	Cellulose acetate (CA) ultrafiltration membranes	156:203	Cellulose acetate (CA) ultrafiltration membranes are attracting more attention in wastewater purification due to its biodegradability and eco-friendly.
32061851	4	38	theme	high-pressure	765:777	arg1	homogenization					779:792	high-pressure homogenization	765:792	high-pressure homogenization	765:792	LCNFs was prepared by using a combined method of one-step chemical pretreatment and acid hydrolysis coupled with high-pressure homogenization.
32061851	5	39	theme	188.23 L·m-2·h-1	982:997	arg1	membranes					1018:1026	ultrafiltration membranes	1002:1026	ultrafiltration membranes	1002:1026	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	39	theme	188.23 L·m-2·h-1	982:997	arg1	strain-at-break					919:933	strain-at-break	919:933	strain-at-break of 12.21%	919:943	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	39	theme	188.23 L·m-2·h-1	982:997	arg1	strength					894:901	high tensile strength	881:901	high tensile strength of 7.08 MPa	881:913	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	39	theme	188.23 L·m-2·h-1	982:997	arg1	permeability					966:977	high filtration permeability	950:977	high filtration permeability of 188.23 L·m-2·h-1	950:997	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	2	40	theme	high	364:367	arg1	susceptibility					369:382	high susceptibility	364:382	high susceptibility to bacterial corrosion	364:405	The application of CA membranes, however, is limited by high susceptibility to bacterial corrosion and lack of mechanical tolerance that results in loss of life.
32061851	0	41	theme	acetate	76:82	arg1	membranes					100:108	cellulose acetate ultrafiltration membranes	66:108	cellulose acetate ultrafiltration membranes	66:108	Enhanced permeability, mechanical and antibacterial properties of cellulose acetate ultrafiltration membranes incorporated with lignocellulose nanofibrils.
32061851	5	42	theme	7.08 MPa	906:913	arg1	membranes					1018:1026	ultrafiltration membranes	1002:1026	ultrafiltration membranes	1002:1026	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	42	theme	7.08 MPa	906:913	arg1	strain-at-break					919:933	strain-at-break	919:933	strain-at-break of 12.21%	919:943	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	42	theme	7.08 MPa	906:913	arg1	strength					894:901	high tensile strength	881:901	high tensile strength of 7.08 MPa	881:913	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	42	theme	7.08 MPa	906:913	arg1	permeability					966:977	high filtration permeability	950:977	high filtration permeability of 188.23 L·m-2·h-1	950:997	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	3	43	theme	inversion	641:649	arg1	strategy					623:630	a strategy	621:630	a strategy of phase inversion	621:649	To solve the above problems, we first fabricated the CA-based composite membranes incorporated with bamboo-based lignocellulose nanofibrils (LCNFs) by a strategy of phase inversion.
32061851	5	44	theme	tensile	886:892	arg1	membranes					1018:1026	ultrafiltration membranes	1002:1026	ultrafiltration membranes	1002:1026	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	44	theme	tensile	886:892	arg1	strain-at-break					919:933	strain-at-break	919:933	strain-at-break of 12.21%	919:943	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	44	theme	tensile	886:892	arg1	strength					894:901	high tensile strength	881:901	high tensile strength of 7.08 MPa	881:913	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	44	theme	tensile	886:892	arg1	permeability					966:977	high filtration permeability	950:977	high filtration permeability of 188.23 L·m-2·h-1	950:997	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	4	45	theme	pretreatment	719:730	arg1	method					691:696	a combined method	680:696	a combined method of one-step chemical pretreatment and acid hydrolysis coupled with high-pressure homogenization	680:792	LCNFs was prepared by using a combined method of one-step chemical pretreatment and acid hydrolysis coupled with high-pressure homogenization.
32061851	4	46	theme	combined	682:689	arg1	method					691:696	a combined method	680:696	a combined method of one-step chemical pretreatment and acid hydrolysis coupled with high-pressure homogenization	680:792	LCNFs was prepared by using a combined method of one-step chemical pretreatment and acid hydrolysis coupled with high-pressure homogenization.
32061851	0	47	theme	cellulose	66:74	arg1	membranes					100:108	cellulose acetate ultrafiltration membranes	66:108	cellulose acetate ultrafiltration membranes	66:108	Enhanced permeability, mechanical and antibacterial properties of cellulose acetate ultrafiltration membranes incorporated with lignocellulose nanofibrils.
32061851	5	48	from	lignin	851:856	arg1	LCNFs					865:869	the LCNFs	861:869	the LCNFs	861:869	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	49	theme	high	881:884	arg1	membranes					1018:1026	ultrafiltration membranes	1002:1026	ultrafiltration membranes	1002:1026	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	49	theme	high	881:884	arg1	strain-at-break					919:933	strain-at-break	919:933	strain-at-break of 12.21%	919:943	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	49	theme	high	881:884	arg1	strength					894:901	high tensile strength	881:901	high tensile strength of 7.08 MPa	881:913	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	5	49	theme	high	881:884	arg1	permeability					966:977	high filtration permeability	950:977	high filtration permeability of 188.23 L·m-2·h-1	950:997	The as-prepared CA/LCNFs composite membranes with 4 wt% lignin in the LCNFs exhibited high tensile strength of 7.08 MPa and strain-at-break of 12.21%, and high filtration permeability of 188.23 L·m-2·h-1 as ultrafiltration membranes for wastewater treatment, which could obviously inhibit the growth of Escherichia coli.
32061851	4	50	theme	chemical	710:717	arg1	pretreatment					719:730	one-step chemical pretreatment	701:730	one-step chemical pretreatment	701:730	LCNFs was prepared by using a combined method of one-step chemical pretreatment and acid hydrolysis coupled with high-pressure homogenization.
33545855	8	0	theme	tensile	1115:1121	arg1	strength					1123:1130	tensile strength	1115:1130	tensile strength	1115:1130	The optimal formulation of tensile strength was obtained when PCL/PEG/chitosan-keratin were combined at a ratio of 80/19/1 w/w.
33545855	10	1	theme	vitro	1475:1479	arg1	testing					1494:1500	vitro cytotoxicity testing	1475:1500	vitro cytotoxicity testing	1475:1500	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	8	2	theme	80/19/1	1203:1209	arg1	ratio					1194:1198	a ratio	1192:1198	a ratio of 80/19/1 w/w	1192:1213	The optimal formulation of tensile strength was obtained when PCL/PEG/chitosan-keratin were combined at a ratio of 80/19/1 w/w.
33545855	4	3	theme	uniform	647:653	arg1	thickness					655:663	a uniform thickness	645:663	a uniform thickness of fibres	645:673	Results showed that the sutures extruded homogeneously at a temperature of 63 ± 1 °C providing a uniform thickness of fibres.
33545855	0	4	theme	wound	109:113	arg1	healing					115:121	wound healing	109:121	wound healing	109:121	Fabrication and characterisation of melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures designed for wound healing.
33545855	7	5	theme	PEG	1051:1053	arg1	additions					1077:1085	the PEG, chitosan and keratin additions	1047:1085	the PEG, chitosan and keratin additions	1047:1085	Tensile properties of the sutures were clearly affected by the PEG, chitosan and keratin additions.
33545855	8	6	theme	strength	1123:1130	arg1	formulation					1100:1110	The optimal formulation	1088:1110	The optimal formulation of tensile strength	1088:1130	The optimal formulation of tensile strength was obtained when PCL/PEG/chitosan-keratin were combined at a ratio of 80/19/1 w/w.
33545855	6	7	dep	Fourier	843:849	arg1	transform					851:859	transform	851:859	transform infrared (FTIR) spectroscopy	851:888	Fourier transform infrared (FTIR) spectroscopy indicated that the presence of hydrogen bonds between the polymers improved material miscibility.
33545855	10	8	theme	cytotoxicity	1481:1492	arg1	testing					1494:1500	vitro cytotoxicity testing	1475:1500	vitro cytotoxicity testing	1475:1500	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	11	9	theme	PCL/PEG/chitosan/keratin/drug	1552:1580	arg1	sutures					1582:1588	the PCL/PEG/chitosan/keratin/drug sutures	1548:1588	the PCL/PEG/chitosan/keratin/drug sutures	1548:1588	The anti-inflammatory properties imparted by the PCL/PEG/chitosan/keratin/drug sutures may further the use of composite sutures for wound healing in clinical settings.
33545855	5	10	theme	miscible	802:809	arg1	dispersions					817:827	completely amorphous and miscible solid dispersions	777:827	completely amorphous and miscible solid dispersions	777:827	Analysis by Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) showed that completely amorphous and miscible solid dispersions were created.
33545855	5	11	theme	Thermogravimetric	732:748	arg1	TGA					760:762	TGA	760:762	TGA	760:762	Analysis by Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) showed that completely amorphous and miscible solid dispersions were created.
33545855	5	11	theme	Thermogravimetric	732:748	arg1	Analysis					750:757	Thermogravimetric Analysis	732:757	Thermogravimetric Analysis (TGA)	732:763	Analysis by Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) showed that completely amorphous and miscible solid dispersions were created.
33545855	9	12	theme	PEG/PCL/chitosan/keratin	1278:1301	arg1	blends					1303:1308	the PEG/PCL/chitosan/keratin blends	1274:1308	the PEG/PCL/chitosan/keratin blends at various combinations	1274:1332	Rapid and sustained drug release rates were achieved with the PEG/PCL/chitosan/keratin blends at various combinations.
33545855	6	13	dep	infrared	861:868	arg1	FTIR					871:874	FTIR	871:874	FTIR	871:874	Fourier transform infrared (FTIR) spectroscopy indicated that the presence of hydrogen bonds between the polymers improved material miscibility.
33545855	5	14	theme	solid	811:815	arg1	dispersions					817:827	completely amorphous and miscible solid dispersions	777:827	completely amorphous and miscible solid dispersions	777:827	Analysis by Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) showed that completely amorphous and miscible solid dispersions were created.
33545855	3	15	from	performance	437:447	arg1	contact					483:489	the contact	479:489	the contact with the human keratinocyte cell line HaCat	479:533	Lastly, the performance of the drug-loaded sutures in the contact with the human keratinocyte cell line HaCat were assessed.
33545855	5	16	theme	Differential	688:699	arg1	Calorimetry					710:720	Differential Scanning Calorimetry	688:720	Differential Scanning Calorimetry (DSC)	688:726	Analysis by Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) showed that completely amorphous and miscible solid dispersions were created.
33545855	5	16	theme	Differential	688:699	arg1	DSC					723:725	DSC	723:725	DSC	723:725	Analysis by Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) showed that completely amorphous and miscible solid dispersions were created.
33545855	11	17	theme	wound	1635:1639	arg1	healing					1641:1647	wound healing	1635:1647	wound healing in clinical settings	1635:1668	The anti-inflammatory properties imparted by the PCL/PEG/chitosan/keratin/drug sutures may further the use of composite sutures for wound healing in clinical settings.
33545855	0	18	theme	drug-eluting	75:86	arg1	sutures					88:94	melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures	36:94	melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures	36:94	Fabrication and characterisation of melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures designed for wound healing.
33545855	6	19	theme	material	966:973	arg1	miscibility					975:985	material miscibility	966:985	material miscibility	966:985	Fourier transform infrared (FTIR) spectroscopy indicated that the presence of hydrogen bonds between the polymers improved material miscibility.
33545855	5	20	theme	Scanning	701:708	arg1	Calorimetry					710:720	Differential Scanning Calorimetry	688:720	Differential Scanning Calorimetry (DSC)	688:726	Analysis by Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) showed that completely amorphous and miscible solid dispersions were created.
33545855	5	20	theme	Scanning	701:708	arg1	DSC					723:725	DSC	723:725	DSC	723:725	Analysis by Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) showed that completely amorphous and miscible solid dispersions were created.
33545855	2	21	theme	mechanical	327:336	arg1	properties					338:347	their physical, thermal and mechanical properties	299:347	their physical, thermal and mechanical properties	299:347	Polymer sutures were evaluated based on their physical, thermal and mechanical properties, while the drug-eluting sutures were evaluated for drug release properties.
33545855	10	22	theme	potassium	1403:1411	arg1	%					1387:1387	30 wt%	1382:1387	30 wt% of diclofenac potassium	1382:1411	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	10	22	theme	potassium	1403:1411	arg1	potassium					1403:1411	diclofenac potassium	1392:1411	diclofenac potassium	1392:1411	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	1	23	theme	hot-melt	229:236	arg1	technique					248:256	the hot-melt extrusion technique	225:256	the hot-melt extrusion technique	225:256	Diclofenac potassium loaded sutures based upon PEG/PCL/chitosan-keratin blends were fabricated using the hot-melt extrusion technique.
33545855	11	24	theme	anti-inflammatory	1507:1523	arg1	properties					1525:1534	The anti-inflammatory properties	1503:1534	The anti-inflammatory properties imparted by the PCL/PEG/chitosan/keratin/drug sutures	1503:1588	The anti-inflammatory properties imparted by the PCL/PEG/chitosan/keratin/drug sutures may further the use of composite sutures for wound healing in clinical settings.
33545855	9	25	theme	various	1313:1319	arg1	combinations					1321:1332	various combinations	1313:1332	various combinations	1313:1332	Rapid and sustained drug release rates were achieved with the PEG/PCL/chitosan/keratin blends at various combinations.
33545855	10	26	theme	diclofenac	1392:1401	arg1	potassium					1403:1411	diclofenac potassium	1392:1411	diclofenac potassium	1392:1411	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	1	27	theme	extrusion	238:246	arg1	technique					248:256	the hot-melt extrusion technique	225:256	the hot-melt extrusion technique	225:256	Diclofenac potassium loaded sutures based upon PEG/PCL/chitosan-keratin blends were fabricated using the hot-melt extrusion technique.
33545855	11	28	theme	composite	1613:1621	arg1	sutures					1623:1629	composite sutures	1613:1629	composite sutures	1613:1629	The anti-inflammatory properties imparted by the PCL/PEG/chitosan/keratin/drug sutures may further the use of composite sutures for wound healing in clinical settings.
33545855	6	29	theme	infrared	861:868	arg1	spectroscopy					877:888	infrared (FTIR) spectroscopy	861:888	infrared (FTIR) spectroscopy	861:888	Fourier transform infrared (FTIR) spectroscopy indicated that the presence of hydrogen bonds between the polymers improved material miscibility.
33545855	1	30	theme	Diclofenac	124:133	arg1	potassium					135:143	Diclofenac potassium	124:143	Diclofenac potassium loaded sutures based upon PEG/PCL/chitosan-keratin blends	124:201	Diclofenac potassium loaded sutures based upon PEG/PCL/chitosan-keratin blends were fabricated using the hot-melt extrusion technique.
33545855	11	31	theme	sutures	1623:1629	arg1	use					1606:1608	the use	1602:1608	the use of composite sutures for wound healing in clinical settings	1602:1668	The anti-inflammatory properties imparted by the PCL/PEG/chitosan/keratin/drug sutures may further the use of composite sutures for wound healing in clinical settings.
33545855	7	32	theme	sutures	1014:1020	arg1	properties					996:1005	Tensile properties	988:1005	Tensile properties of the sutures	988:1020	Tensile properties of the sutures were clearly affected by the PEG, chitosan and keratin additions.
33545855	8	33	theme	optimal	1092:1098	arg1	formulation					1100:1110	The optimal formulation	1088:1110	The optimal formulation of tensile strength	1088:1130	The optimal formulation of tensile strength was obtained when PCL/PEG/chitosan-keratin were combined at a ratio of 80/19/1 w/w.
33545855	2	34	theme	drug-eluting	360:371	arg1	sutures					373:379	the drug-eluting sutures	356:379	the drug-eluting sutures	356:379	Polymer sutures were evaluated based on their physical, thermal and mechanical properties, while the drug-eluting sutures were evaluated for drug release properties.
33545855	10	35	theme	viability	1438:1446	arg1	rates					1466:1470	high cell viability and wound healing rates	1428:1470	high cell viability and wound healing rates	1428:1470	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	11	36	from	healing	1641:1647	arg1	settings					1661:1668	clinical settings	1652:1668	clinical settings	1652:1668	The anti-inflammatory properties imparted by the PCL/PEG/chitosan/keratin/drug sutures may further the use of composite sutures for wound healing in clinical settings.
33545855	11	37	theme	clinical	1652:1659	arg1	settings					1661:1668	clinical settings	1652:1668	clinical settings	1652:1668	The anti-inflammatory properties imparted by the PCL/PEG/chitosan/keratin/drug sutures may further the use of composite sutures for wound healing in clinical settings.
33545855	10	38	theme	healing	1458:1464	arg1	rates					1466:1470	high cell viability and wound healing rates	1428:1470	high cell viability and wound healing rates	1428:1470	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	1	39	theme	loaded	145:150	arg1	sutures					152:158	Diclofenac potassium loaded sutures	124:158	Diclofenac potassium loaded sutures based upon PEG/PCL/chitosan-keratin blends	124:201	Diclofenac potassium loaded sutures based upon PEG/PCL/chitosan-keratin blends were fabricated using the hot-melt extrusion technique.
33545855	10	40	theme	cell	1433:1436	arg1	viability					1438:1446	cell viability	1433:1446	cell viability	1433:1446	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	0	41	theme	chitosan/keratin/PCL/PEG	50:73	arg1	sutures					88:94	melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures	36:94	melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures	36:94	Fabrication and characterisation of melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures designed for wound healing.
33545855	4	42	theme	63 ± 1 °C	625:633	arg1	temperature					610:620	a temperature	608:620	a temperature of 63 ± 1 °C providing a uniform thickness of fibres	608:673	Results showed that the sutures extruded homogeneously at a temperature of 63 ± 1 °C providing a uniform thickness of fibres.
33545855	10	43	with	PCL/PEG/chitosan-keratin	1352:1375	arg1	%					1387:1387	30 wt%	1382:1387	30 wt% of diclofenac potassium	1382:1411	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	10	43	with	PCL/PEG/chitosan-keratin	1352:1375	arg1	potassium					1403:1411	diclofenac potassium	1392:1411	diclofenac potassium	1392:1411	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	10	44	theme	high	1428:1431	arg1	rates					1466:1470	high cell viability and wound healing rates	1428:1470	high cell viability and wound healing rates	1428:1470	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	3	45	theme	keratinocyte	506:517	arg1	line					524:527	human keratinocyte cell line	500:527	the human keratinocyte cell line HaCat	496:533	Lastly, the performance of the drug-loaded sutures in the contact with the human keratinocyte cell line HaCat were assessed.
33545855	0	46	theme	melt-extruded	36:48	arg1	sutures					88:94	melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures	36:94	melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures	36:94	Fabrication and characterisation of melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures designed for wound healing.
33545855	5	47	theme	amorphous	788:796	arg1	dispersions					817:827	completely amorphous and miscible solid dispersions	777:827	completely amorphous and miscible solid dispersions	777:827	Analysis by Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) showed that completely amorphous and miscible solid dispersions were created.
33545855	9	48	theme	Rapid	1216:1220	arg1	rates					1249:1253	Rapid and sustained drug release rates	1216:1253	Rapid and sustained drug release rates	1216:1253	Rapid and sustained drug release rates were achieved with the PEG/PCL/chitosan/keratin blends at various combinations.
33545855	3	49	theme	cell	519:522	arg1	line					524:527	human keratinocyte cell line	500:527	the human keratinocyte cell line HaCat	496:533	Lastly, the performance of the drug-loaded sutures in the contact with the human keratinocyte cell line HaCat were assessed.
33545855	0	50	theme	sutures	88:94	arg1	characterisation					16:31	characterisation	16:31	characterisation	16:31	Fabrication and characterisation of melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures designed for wound healing.
33545855	0	50	theme	sutures	88:94	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and characterisation of melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures designed for wound healing.
33545855	3	51	with	contact	483:489	arg1	line					524:527	human keratinocyte cell line	500:527	the human keratinocyte cell line HaCat	496:533	Lastly, the performance of the drug-loaded sutures in the contact with the human keratinocyte cell line HaCat were assessed.
33545855	6	52	theme	bonds	930:934	arg1	presence					909:916	the presence	905:916	the presence of hydrogen bonds between the polymers	905:955	Fourier transform infrared (FTIR) spectroscopy indicated that the presence of hydrogen bonds between the polymers improved material miscibility.
33545855	2	53	theme	release	405:411	arg1	properties					413:422	drug release properties	400:422	drug release properties	400:422	Polymer sutures were evaluated based on their physical, thermal and mechanical properties, while the drug-eluting sutures were evaluated for drug release properties.
33545855	3	54	theme	sutures	468:474	arg1	performance					437:447	the performance	433:447	the performance of the drug-loaded sutures in the contact with the human keratinocyte cell line HaCat	433:533	Lastly, the performance of the drug-loaded sutures in the contact with the human keratinocyte cell line HaCat were assessed.
33545855	9	55	theme	release	1241:1247	arg1	rates					1249:1253	Rapid and sustained drug release rates	1216:1253	Rapid and sustained drug release rates	1216:1253	Rapid and sustained drug release rates were achieved with the PEG/PCL/chitosan/keratin blends at various combinations.
33545855	6	56	theme	hydrogen	921:928	arg1	bonds					930:934	hydrogen bonds	921:934	hydrogen bonds	921:934	Fourier transform infrared (FTIR) spectroscopy indicated that the presence of hydrogen bonds between the polymers improved material miscibility.
33545855	9	57	theme	sustained	1226:1234	arg1	rates					1249:1253	Rapid and sustained drug release rates	1216:1253	Rapid and sustained drug release rates	1216:1253	Rapid and sustained drug release rates were achieved with the PEG/PCL/chitosan/keratin blends at various combinations.
33545855	2	58	theme	drug	400:403	arg1	properties					413:422	drug release properties	400:422	drug release properties	400:422	Polymer sutures were evaluated based on their physical, thermal and mechanical properties, while the drug-eluting sutures were evaluated for drug release properties.
33545855	10	59	theme	PCL/PEG/chitosan-keratin	1352:1375	arg1	PCL/PEG/chitosan-keratin					1352:1375	PCL/PEG/chitosan-keratin	1352:1375	PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium	1352:1411	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	10	59	theme	PCL/PEG/chitosan-keratin	1352:1375	arg1	composite					1339:1347	The composite	1335:1347	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium	1335:1411	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	9	60	from	combinations	1321:1332	arg1	blends					1303:1308	the PEG/PCL/chitosan/keratin blends	1274:1308	the PEG/PCL/chitosan/keratin blends at various combinations	1274:1332	Rapid and sustained drug release rates were achieved with the PEG/PCL/chitosan/keratin blends at various combinations.
33545855	9	61	theme	drug	1236:1239	arg1	rates					1249:1253	Rapid and sustained drug release rates	1216:1253	Rapid and sustained drug release rates	1216:1253	Rapid and sustained drug release rates were achieved with the PEG/PCL/chitosan/keratin blends at various combinations.
33545855	1	62	theme	potassium	135:143	arg1	sutures					152:158	Diclofenac potassium loaded sutures	124:158	Diclofenac potassium loaded sutures based upon PEG/PCL/chitosan-keratin blends	124:201	Diclofenac potassium loaded sutures based upon PEG/PCL/chitosan-keratin blends were fabricated using the hot-melt extrusion technique.
33545855	10	63	theme	wound	1452:1456	arg1	healing					1458:1464	wound healing	1452:1464	wound healing	1452:1464	The composite of PCL/PEG/chitosan-keratin with 30 wt% of diclofenac potassium also exhibited high cell viability and wound healing rates in vitro cytotoxicity testing.
33545855	2	64	theme	Polymer	259:265	arg1	sutures					267:273	Polymer sutures	259:273	Polymer sutures	259:273	Polymer sutures were evaluated based on their physical, thermal and mechanical properties, while the drug-eluting sutures were evaluated for drug release properties.
33545855	2	65	theme	thermal	315:321	arg1	properties					338:347	their physical, thermal and mechanical properties	299:347	their physical, thermal and mechanical properties	299:347	Polymer sutures were evaluated based on their physical, thermal and mechanical properties, while the drug-eluting sutures were evaluated for drug release properties.
33545855	7	66	theme	keratin	1069:1075	arg1	additions					1077:1085	the PEG, chitosan and keratin additions	1047:1085	the PEG, chitosan and keratin additions	1047:1085	Tensile properties of the sutures were clearly affected by the PEG, chitosan and keratin additions.
33545855	1	67	theme	PEG/PCL/chitosan-keratin	171:194	arg1	blends					196:201	PEG/PCL/chitosan-keratin blends	171:201	PEG/PCL/chitosan-keratin blends	171:201	Diclofenac potassium loaded sutures based upon PEG/PCL/chitosan-keratin blends were fabricated using the hot-melt extrusion technique.
33545855	7	68	theme	Tensile	988:994	arg1	properties					996:1005	Tensile properties	988:1005	Tensile properties of the sutures	988:1020	Tensile properties of the sutures were clearly affected by the PEG, chitosan and keratin additions.
33545855	4	69	theme	fibres	668:673	arg1	thickness					655:663	a uniform thickness	645:663	a uniform thickness of fibres	645:673	Results showed that the sutures extruded homogeneously at a temperature of 63 ± 1 °C providing a uniform thickness of fibres.
33545855	3	70	dep	line	524:527	arg1	HaCat					529:533	HaCat	529:533	the human keratinocyte cell line HaCat	496:533	Lastly, the performance of the drug-loaded sutures in the contact with the human keratinocyte cell line HaCat were assessed.
33545855	3	71	theme	human	500:504	arg1	line					524:527	human keratinocyte cell line	500:527	the human keratinocyte cell line HaCat	496:533	Lastly, the performance of the drug-loaded sutures in the contact with the human keratinocyte cell line HaCat were assessed.
33545855	3	72	theme	drug-loaded	456:466	arg1	sutures					468:474	the drug-loaded sutures	452:474	the drug-loaded sutures	452:474	Lastly, the performance of the drug-loaded sutures in the contact with the human keratinocyte cell line HaCat were assessed.
33545855	2	73	theme	physical	305:312	arg1	properties					338:347	their physical, thermal and mechanical properties	299:347	their physical, thermal and mechanical properties	299:347	Polymer sutures were evaluated based on their physical, thermal and mechanical properties, while the drug-eluting sutures were evaluated for drug release properties.
33545855	7	74	theme	chitosan	1056:1063	arg1	additions					1077:1085	the PEG, chitosan and keratin additions	1047:1085	the PEG, chitosan and keratin additions	1047:1085	Tensile properties of the sutures were clearly affected by the PEG, chitosan and keratin additions.
33971231	6	0	dep	in	1357:1358	arg1	vitro					1360:1364	vitro	1360:1364	vitro	1360:1364	Furthermore, the oxidized hydroxyethyl cellulose-based hydrogel did exhibit good pH environment adaptability and noncytotoxicity in vitro test.
33971231	7	1	theme	new	1602:1604	arg1	strategy					1606:1613	a new strategy	1600:1613	a new strategy for the development of smart, stylish contact lenses	1600:1666	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	6	2	theme	good	1304:1307	arg1	environment					1312:1322	good pH environment adaptability and noncytotoxicity in vitro test	1304:1369	environment	1312:1322	Furthermore, the oxidized hydroxyethyl cellulose-based hydrogel did exhibit good pH environment adaptability and noncytotoxicity in vitro test.
33971231	6	3	theme	oxidized	1245:1252	arg1	hydrogel					1283:1290	the oxidized hydroxyethyl cellulose-based hydrogel	1241:1290	the oxidized hydroxyethyl cellulose-based hydrogel	1241:1290	Furthermore, the oxidized hydroxyethyl cellulose-based hydrogel did exhibit good pH environment adaptability and noncytotoxicity in vitro test.
33971231	2	4	theme	stimuli-responsive	296:313	arg1	materials					315:323	stimuli-responsive materials	296:323	stimuli-responsive materials with hydrophilicity	296:343	Stimuli-hydrogels as one kind of stimuli-responsive materials with hydrophilicity, demonstrate huge potential in developing intelligent devices for biomedical application.
33971231	1	5	theme	higher	189:194	arg1	requirements					196:207	higher requirements	189:207	higher requirements	189:207	With the development of smart devices, higher requirements are put forward for the stimuli-responsive materials.
33971231	7	6	theme	contact	1566:1572	arg1	lenses					1574:1579	safe, fashionable and pH- detectable contact lenses	1529:1579	safe, fashionable and pH- detectable contact lenses	1529:1579	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	2	7	theme	huge	358:361	arg1	potential					363:371	huge potential	358:371	huge potential in developing intelligent devices for biomedical application	358:432	Stimuli-hydrogels as one kind of stimuli-responsive materials with hydrophilicity, demonstrate huge potential in developing intelligent devices for biomedical application.
33971231	4	8	theme	due	699:701	arg1	hydrogel					690:697	this oxidized hydroxyethyl cellulose-based hydrogel	647:697	this oxidized hydroxyethyl cellulose-based hydrogel due to its structure and performance	647:734	Subsequently, a series of tests toward this oxidized hydroxyethyl cellulose-based hydrogel due to its structure and performance was applied.
33971231	5	9	theme	oxidized	759:766	arg1	templates					838:846	biomacromolecule templates	821:846	biomacromolecule templates	821:846	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	9	theme	oxidized	759:766	arg1	chains					801:806	the oxidized hydroxyethyl cellulose molecular chains	755:806	the oxidized hydroxyethyl cellulose molecular chains	755:806	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	10	theme	cellulose	781:789	arg1	templates					838:846	biomacromolecule templates	821:846	biomacromolecule templates	821:846	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	10	theme	cellulose	781:789	arg1	chains					801:806	the oxidized hydroxyethyl cellulose molecular chains	755:806	the oxidized hydroxyethyl cellulose molecular chains	755:806	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	11	theme	oxidized	1147:1154	arg1	substrate					1217:1225	the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate	1143:1225	the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate	1143:1225	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	12	theme	hydrogen	880:887	arg1	bonds					889:893	hydrogen bonds	880:893	hydrogen bonds	880:893	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	13	theme	mechanical	912:921	arg1	properties					923:932	unique mechanical properties	905:932	unique mechanical properties	905:932	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	7	14	theme	potential	1475:1483	arg1	applications					1485:1496	potential applications	1475:1496	potential applications	1475:1496	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	5	15	theme	photo-	1114:1119	arg1	sensitivity					1128:1138	photo- and pH sensitivity	1114:1138	sensitivity	1128:1138	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	16	theme	compressive	990:1000	arg1	capacity					1002:1009	remarkable compressive capacity	979:1009	remarkable compressive capacity	979:1009	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	17	dep	bond	1028:1031	arg1	derivative					1081:1090	allyl spirooxazine derivative	1062:1090	allyl spirooxazine derivative	1062:1090	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	17	dep	bond	1028:1031	arg1	spirooxazine					1048:1059	functionalized spirooxazine	1033:1059	a double bond functionalized spirooxazine (allyl spirooxazine derivative)	1019:1091	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	18	theme	pH	1125:1126	arg1	sensitivity					1128:1138	photo- and pH sensitivity	1114:1138	sensitivity	1128:1138	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	7	19	theme	hydroxyethyl	1433:1444	arg1	hydrogel					1462:1469	the designed oxidized hydroxyethyl cellulose-based hydrogel	1411:1469	the designed oxidized hydroxyethyl cellulose-based hydrogel	1411:1469	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	5	20	theme	biomacromolecule	821:836	arg1	templates					838:846	biomacromolecule templates	821:846	biomacromolecule templates	821:846	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	20	theme	biomacromolecule	821:836	arg1	chains					801:806	the oxidized hydroxyethyl cellulose molecular chains	755:806	the oxidized hydroxyethyl cellulose molecular chains	755:806	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	21	theme	T	1207:1207	arg1	hydrogel					1197:1204	hydroxyethyl cellulose-based transparent hydrogel	1156:1204	the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate	1143:1225	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	21	theme	T	1207:1207	arg1	%					1214:1214	T% = 93%	1207:1214	T% = 93%	1207:1214	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	7	22	dep	development	1514:1524	arg1	prospect					1498:1505	prospect	1498:1505	prospect	1498:1505	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	6	23	dep	environment	1312:1322	arg1	test					1366:1369	in vitro test	1357:1369	in vitro test	1357:1369	Furthermore, the oxidized hydroxyethyl cellulose-based hydrogel did exhibit good pH environment adaptability and noncytotoxicity in vitro test.
33971231	6	23	dep	environment	1312:1322	arg1	adaptability					1324:1335	adaptability	1324:1335	adaptability	1324:1335	Furthermore, the oxidized hydroxyethyl cellulose-based hydrogel did exhibit good pH environment adaptability and noncytotoxicity in vitro test.
33971231	0	24	theme	transparent	90:100	arg1	properties					119:128	unique mechanical, transparent and photochromic properties	71:128	unique mechanical, transparent and photochromic properties	71:128	Development of oxidized hydroxyethyl cellulose-based hydrogel enabling unique mechanical, transparent and photochromic properties for contact lenses.
33971231	5	25	theme	=	1210:1210	arg1	hydrogel					1197:1204	hydroxyethyl cellulose-based transparent hydrogel	1156:1204	the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate	1143:1225	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	25	theme	=	1210:1210	arg1	%					1214:1214	T% = 93%	1207:1214	T% = 93%	1207:1214	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	1	26	theme	devices	180:186	arg1	development					159:169	the development	155:169	the development of smart devices	155:186	With the development of smart devices, higher requirements are put forward for the stimuli-responsive materials.
33971231	0	27	theme	photochromic	106:117	arg1	properties					119:128	unique mechanical, transparent and photochromic properties	71:128	unique mechanical, transparent and photochromic properties	71:128	Development of oxidized hydroxyethyl cellulose-based hydrogel enabling unique mechanical, transparent and photochromic properties for contact lenses.
33971231	5	28	theme	cellulose-based	1169:1183	arg1	hydrogel					1197:1204	hydroxyethyl cellulose-based transparent hydrogel	1156:1204	the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate	1143:1225	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	28	theme	cellulose-based	1169:1183	arg1	%					1214:1214	T% = 93%	1207:1214	T% = 93%	1207:1214	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	29	theme	functionalized	1033:1046	arg1	derivative					1081:1090	allyl spirooxazine derivative	1062:1090	allyl spirooxazine derivative	1062:1090	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	29	theme	functionalized	1033:1046	arg1	spirooxazine					1048:1059	functionalized spirooxazine	1033:1059	a double bond functionalized spirooxazine (allyl spirooxazine derivative)	1019:1091	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	7	30	theme	lenses	1661:1666	arg1	development					1623:1633	the development	1619:1633	the development of smart, stylish contact lenses	1619:1666	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	5	31	theme	hydrogel	1197:1204	arg1	substrate					1217:1225	the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate	1143:1225	the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate	1143:1225	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	7	32	theme	oxidized	1424:1431	arg1	hydrogel					1462:1469	the designed oxidized hydroxyethyl cellulose-based hydrogel	1411:1469	the designed oxidized hydroxyethyl cellulose-based hydrogel	1411:1469	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	6	33	theme	cellulose-based	1267:1281	arg1	hydrogel					1283:1290	the oxidized hydroxyethyl cellulose-based hydrogel	1241:1290	the oxidized hydroxyethyl cellulose-based hydrogel	1241:1290	Furthermore, the oxidized hydroxyethyl cellulose-based hydrogel did exhibit good pH environment adaptability and noncytotoxicity in vitro test.
33971231	0	34	theme	oxidized	15:22	arg1	hydrogel					53:60	oxidized hydroxyethyl cellulose-based hydrogel	15:60	oxidized hydroxyethyl cellulose-based hydrogel	15:60	Development of oxidized hydroxyethyl cellulose-based hydrogel enabling unique mechanical, transparent and photochromic properties for contact lenses.
33971231	5	35	theme	double	1021:1026	arg1	bond					1028:1031	a double bond functionalized spirooxazine (allyl spirooxazine derivative)	1019:1091	a double bond functionalized spirooxazine (allyl spirooxazine derivative)	1019:1091	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	0	36	theme	cellulose-based	37:51	arg1	hydrogel					53:60	oxidized hydroxyethyl cellulose-based hydrogel	15:60	oxidized hydroxyethyl cellulose-based hydrogel	15:60	Development of oxidized hydroxyethyl cellulose-based hydrogel enabling unique mechanical, transparent and photochromic properties for contact lenses.
33971231	5	37	theme	Schiff	856:861	arg1	base					863:866	Schiff base	856:866	Schiff base	856:866	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	0	38	theme	mechanical	78:87	arg1	properties					119:128	unique mechanical, transparent and photochromic properties	71:128	unique mechanical, transparent and photochromic properties	71:128	Development of oxidized hydroxyethyl cellulose-based hydrogel enabling unique mechanical, transparent and photochromic properties for contact lenses.
33971231	6	39	theme	hydroxyethyl	1254:1265	arg1	hydrogel					1283:1290	the oxidized hydroxyethyl cellulose-based hydrogel	1241:1290	the oxidized hydroxyethyl cellulose-based hydrogel	1241:1290	Furthermore, the oxidized hydroxyethyl cellulose-based hydrogel did exhibit good pH environment adaptability and noncytotoxicity in vitro test.
33971231	3	40	theme	novel	513:517	arg1	hydrogel					529:536	a novel composite hydrogel	511:536	a novel composite hydrogel mainly based on oxidized hydroxyethyl cellulose and allyl co-polymer	511:605	On this basis, we herein report that a sample method was devised to develop a novel composite hydrogel mainly based on oxidized hydroxyethyl cellulose and allyl co-polymer.
33971231	1	41	theme	stimuli-responsive	233:250	arg1	materials					252:260	the stimuli-responsive materials	229:260	the stimuli-responsive materials	229:260	With the development of smart devices, higher requirements are put forward for the stimuli-responsive materials.
33971231	5	42	theme	spirooxazine	1068:1079	arg1	derivative					1081:1090	allyl spirooxazine derivative	1062:1090	allyl spirooxazine derivative	1062:1090	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	42	theme	spirooxazine	1068:1079	arg1	spirooxazine					1048:1059	functionalized spirooxazine	1033:1059	a double bond functionalized spirooxazine (allyl spirooxazine derivative)	1019:1091	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	3	43	theme	oxidized	554:561	arg1	cellulose					576:584	oxidized hydroxyethyl cellulose	554:584	oxidized hydroxyethyl cellulose	554:584	On this basis, we herein report that a sample method was devised to develop a novel composite hydrogel mainly based on oxidized hydroxyethyl cellulose and allyl co-polymer.
33971231	7	44	contain	has	1471:1473	arg1	hydrogel					1462:1469	the designed oxidized hydroxyethyl cellulose-based hydrogel	1411:1469	the designed oxidized hydroxyethyl cellulose-based hydrogel	1411:1469	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	7	44	contain	has	1471:1473	arg2	applications					1485:1496	potential applications	1475:1496	potential applications	1475:1496	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	4	45	theme	hydroxyethyl	661:672	arg1	hydrogel					690:697	this oxidized hydroxyethyl cellulose-based hydrogel	647:697	this oxidized hydroxyethyl cellulose-based hydrogel due to its structure and performance	647:734	Subsequently, a series of tests toward this oxidized hydroxyethyl cellulose-based hydrogel due to its structure and performance was applied.
33971231	2	46	theme	biomedical	411:420	arg1	application					422:432	biomedical application	411:432	biomedical application	411:432	Stimuli-hydrogels as one kind of stimuli-responsive materials with hydrophilicity, demonstrate huge potential in developing intelligent devices for biomedical application.
33971231	3	47	theme	allyl	590:594	arg1	co-polymer					596:605	allyl co-polymer	590:605	allyl co-polymer	590:605	On this basis, we herein report that a sample method was devised to develop a novel composite hydrogel mainly based on oxidized hydroxyethyl cellulose and allyl co-polymer.
33971231	7	48	theme	lenses	1574:1579	arg1	development					1514:1524	the development	1510:1524	the development of safe, fashionable and pH- detectable contact lenses	1510:1579	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	7	49	theme	pH-	1551:1553	arg1	lenses					1574:1579	safe, fashionable and pH- detectable contact lenses	1529:1579	safe, fashionable and pH- detectable contact lenses	1529:1579	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	4	50	theme	tests	634:638	arg1	series					624:629	a series	622:629	a series of tests toward this oxidized hydroxyethyl cellulose-based hydrogel due to its structure and performance	622:734	Subsequently, a series of tests toward this oxidized hydroxyethyl cellulose-based hydrogel due to its structure and performance was applied.
33971231	6	51	theme	in	1357:1358	arg1	test					1366:1369	in vitro test	1357:1369	in vitro test	1357:1369	Furthermore, the oxidized hydroxyethyl cellulose-based hydrogel did exhibit good pH environment adaptability and noncytotoxicity in vitro test.
33971231	2	52	theme	materials	315:323	arg1	kind					288:291	one kind	284:291	one kind of stimuli-responsive materials with hydrophilicity	284:343	Stimuli-hydrogels as one kind of stimuli-responsive materials with hydrophilicity, demonstrate huge potential in developing intelligent devices for biomedical application.
33971231	7	53	theme	detectable	1555:1564	arg1	lenses					1574:1579	safe, fashionable and pH- detectable contact lenses	1529:1579	safe, fashionable and pH- detectable contact lenses	1529:1579	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	7	54	theme	fashionable	1535:1545	arg1	lenses					1574:1579	safe, fashionable and pH- detectable contact lenses	1529:1579	safe, fashionable and pH- detectable contact lenses	1529:1579	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	5	55	theme	fast	935:938	arg1	recovery					940:947	fast recovery	935:947	fast recovery with almost no-hysteresis and remarkable compressive capacity	935:1009	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	7	56	theme	safe	1529:1532	arg1	lenses					1574:1579	safe, fashionable and pH- detectable contact lenses	1529:1579	safe, fashionable and pH- detectable contact lenses	1529:1579	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	5	57	theme	hydroxyethyl	768:779	arg1	templates					838:846	biomacromolecule templates	821:846	biomacromolecule templates	821:846	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	57	theme	hydroxyethyl	768:779	arg1	chains					801:806	the oxidized hydroxyethyl cellulose molecular chains	755:806	the oxidized hydroxyethyl cellulose molecular chains	755:806	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	58	theme	unique	905:910	arg1	properties					923:932	unique mechanical properties	905:932	unique mechanical properties	905:932	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	6	59	theme	pH	1309:1310	arg1	environment					1312:1322	good pH environment adaptability and noncytotoxicity in vitro test	1304:1369	environment	1312:1322	Furthermore, the oxidized hydroxyethyl cellulose-based hydrogel did exhibit good pH environment adaptability and noncytotoxicity in vitro test.
33971231	5	60	theme	hydroxyethyl	1156:1167	arg1	hydrogel					1197:1204	hydroxyethyl cellulose-based transparent hydrogel	1156:1204	the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate	1143:1225	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	60	theme	hydroxyethyl	1156:1167	arg1	%					1214:1214	T% = 93%	1207:1214	T% = 93%	1207:1214	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	61	theme	remarkable	979:988	arg1	capacity					1002:1009	remarkable compressive capacity	979:1009	remarkable compressive capacity	979:1009	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	2	62	with	materials	315:323	arg1	hydrophilicity					330:343	hydrophilicity	330:343	hydrophilicity	330:343	Stimuli-hydrogels as one kind of stimuli-responsive materials with hydrophilicity, demonstrate huge potential in developing intelligent devices for biomedical application.
33971231	7	63	theme	cellulose-based	1446:1460	arg1	hydrogel					1462:1469	the designed oxidized hydroxyethyl cellulose-based hydrogel	1411:1469	the designed oxidized hydroxyethyl cellulose-based hydrogel	1411:1469	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	5	64	theme	%	1208:1208	arg1	hydrogel					1197:1204	hydroxyethyl cellulose-based transparent hydrogel	1156:1204	the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate	1143:1225	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	64	theme	%	1208:1208	arg1	%					1214:1214	T% = 93%	1207:1214	T% = 93%	1207:1214	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	65	used	used	813:816	arg2	templates					838:846	biomacromolecule templates	821:846	biomacromolecule templates	821:846	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	65	used	used	813:816	arg2	chains					801:806	the oxidized hydroxyethyl cellulose molecular chains	755:806	the oxidized hydroxyethyl cellulose molecular chains	755:806	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	1	66	theme	smart	174:178	arg1	devices					180:186	smart devices	174:186	smart devices	174:186	With the development of smart devices, higher requirements are put forward for the stimuli-responsive materials.
33971231	5	67	theme	molecular	791:799	arg1	templates					838:846	biomacromolecule templates	821:846	biomacromolecule templates	821:846	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	67	theme	molecular	791:799	arg1	chains					801:806	the oxidized hydroxyethyl cellulose molecular chains	755:806	the oxidized hydroxyethyl cellulose molecular chains	755:806	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	7	68	theme	contact	1653:1659	arg1	lenses					1661:1666	smart, stylish contact lenses	1638:1666	smart, stylish contact lenses	1638:1666	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	0	69	theme	contact	134:140	arg1	lenses					142:147	contact lenses	134:147	contact lenses	134:147	Development of oxidized hydroxyethyl cellulose-based hydrogel enabling unique mechanical, transparent and photochromic properties for contact lenses.
33971231	5	70	theme	transparent	1185:1195	arg1	hydrogel					1197:1204	hydroxyethyl cellulose-based transparent hydrogel	1156:1204	the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate	1143:1225	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	70	theme	transparent	1185:1195	arg1	%					1214:1214	T% = 93%	1207:1214	T% = 93%	1207:1214	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	7	71	theme	designed	1415:1422	arg1	hydrogel					1462:1469	the designed oxidized hydroxyethyl cellulose-based hydrogel	1411:1469	the designed oxidized hydroxyethyl cellulose-based hydrogel	1411:1469	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	3	72	theme	sample	474:479	arg1	method					481:486	a sample method	472:486	a sample method	472:486	On this basis, we herein report that a sample method was devised to develop a novel composite hydrogel mainly based on oxidized hydroxyethyl cellulose and allyl co-polymer.
33971231	0	73	theme	hydroxyethyl	24:35	arg1	hydrogel					53:60	oxidized hydroxyethyl cellulose-based hydrogel	15:60	oxidized hydroxyethyl cellulose-based hydrogel	15:60	Development of oxidized hydroxyethyl cellulose-based hydrogel enabling unique mechanical, transparent and photochromic properties for contact lenses.
33971231	7	74	theme	advanced	1385:1392	arg1	characteristics					1394:1408	the advanced characteristics	1381:1408	the advanced characteristics	1381:1408	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	0	75	theme	hydrogel	53:60	arg1	Development					0:10	Development	0:10	Development of oxidized hydroxyethyl cellulose-based hydrogel	0:60	Development of oxidized hydroxyethyl cellulose-based hydrogel enabling unique mechanical, transparent and photochromic properties for contact lenses.
33971231	0	76	theme	unique	71:76	arg1	properties					119:128	unique mechanical, transparent and photochromic properties	71:128	unique mechanical, transparent and photochromic properties	71:128	Development of oxidized hydroxyethyl cellulose-based hydrogel enabling unique mechanical, transparent and photochromic properties for contact lenses.
33971231	7	77	theme	smart	1638:1642	arg1	lenses					1661:1666	smart, stylish contact lenses	1638:1666	smart, stylish contact lenses	1638:1666	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	5	78	with	recovery	940:947	arg1	no-hysteresis					961:973	no-hysteresis	961:973	no-hysteresis	961:973	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	78	with	recovery	940:947	arg1	capacity					1002:1009	remarkable compressive capacity	979:1009	remarkable compressive capacity	979:1009	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	2	79	theme	intelligent	387:397	arg1	devices					399:405	intelligent devices	387:405	intelligent devices for biomedical application	387:432	Stimuli-hydrogels as one kind of stimuli-responsive materials with hydrophilicity, demonstrate huge potential in developing intelligent devices for biomedical application.
33971231	5	80	theme	allyl	1062:1066	arg1	derivative					1081:1090	allyl spirooxazine derivative	1062:1090	allyl spirooxazine derivative	1062:1090	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	5	80	theme	allyl	1062:1066	arg1	spirooxazine					1048:1059	functionalized spirooxazine	1033:1059	a double bond functionalized spirooxazine (allyl spirooxazine derivative)	1019:1091	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	4	81	theme	oxidized	652:659	arg1	hydrogel					690:697	this oxidized hydroxyethyl cellulose-based hydrogel	647:697	this oxidized hydroxyethyl cellulose-based hydrogel due to its structure and performance	647:734	Subsequently, a series of tests toward this oxidized hydroxyethyl cellulose-based hydrogel due to its structure and performance was applied.
33971231	3	82	theme	composite	519:527	arg1	hydrogel					529:536	a novel composite hydrogel	511:536	a novel composite hydrogel mainly based on oxidized hydroxyethyl cellulose and allyl co-polymer	511:605	On this basis, we herein report that a sample method was devised to develop a novel composite hydrogel mainly based on oxidized hydroxyethyl cellulose and allyl co-polymer.
33971231	7	83	dep	smart	1638:1642	arg1	stylish					1645:1651	stylish	1645:1651	stylish	1645:1651	Based on the advanced characteristics, the designed oxidized hydroxyethyl cellulose-based hydrogel has potential applications prospect in the development of safe, fashionable and pH- detectable contact lenses, thereby providing a new strategy for the development of smart, stylish contact lenses.
33971231	4	84	theme	cellulose-based	674:688	arg1	hydrogel					690:697	this oxidized hydroxyethyl cellulose-based hydrogel	647:697	this oxidized hydroxyethyl cellulose-based hydrogel due to its structure and performance	647:734	Subsequently, a series of tests toward this oxidized hydroxyethyl cellulose-based hydrogel due to its structure and performance was applied.
33971231	5	85	dep	obtain	898:903	arg1	recovery					940:947	fast recovery	935:947	fast recovery with almost no-hysteresis and remarkable compressive capacity	935:1009	Here, the oxidized hydroxyethyl cellulose molecular chains were used as biomacromolecule templates to form Schiff base, borate and hydrogen bonds to obtain unique mechanical properties (fast recovery with almost no-hysteresis and remarkable compressive capacity), while a double bond functionalized spirooxazine (allyl spirooxazine derivative) was applied to endow photo- and pH sensitivity to the oxidized hydroxyethyl cellulose-based transparent hydrogel (T% = 93%) substrate.
33971231	3	86	theme	hydroxyethyl	563:574	arg1	cellulose					576:584	oxidized hydroxyethyl cellulose	554:584	oxidized hydroxyethyl cellulose	554:584	On this basis, we herein report that a sample method was devised to develop a novel composite hydrogel mainly based on oxidized hydroxyethyl cellulose and allyl co-polymer.
34013840	0	0	theme	ophthalmic	83:92	arg1	F127-chitosan					103:115	thermoresponsive ophthalmic pluronic F127-chitosan	66:115	thermoresponsive ophthalmic pluronic F127-chitosan	66:115	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	3	1	theme	optimized	652:660	arg1	formulation					662:672	The optimized formulation	648:672	The optimized formulation	648:672	The optimized formulation was developed using 22.5 g PL and 0.3 g CS, gels at 33.6 °C, in 22.93 s, and showed the spreadability of 6.2 cm.
34013840	2	2	theme	independent	541:551	arg1	variables					553:561	independent variables	541:561	independent variables	541:561	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	0	3	dep	gel	136:138	arg1	assessment					52:61	in vitro assessment	43:61	in vitro assessment	43:61	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	0	3	dep	gel	136:138	arg1	optimization					25:36	optimization	25:36	optimization	25:36	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	0	3	dep	gel	136:138	arg1	development					12:22	Formulation development	0:22	Formulation development	0:22	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	3	4	from	33.6 °C	726:732	arg1	22.5 g					694:699	22.5 g PL and 0.3 g CS	694:715	22.5 g PL and 0.3 g CS	694:715	The optimized formulation was developed using 22.5 g PL and 0.3 g CS, gels at 33.6 °C, in 22.93 s, and showed the spreadability of 6.2 cm.
34013840	3	4	from	33.6 °C	726:732	arg1	gels					718:721	gels	718:721	gels at 33.6 °C	718:732	The optimized formulation was developed using 22.5 g PL and 0.3 g CS, gels at 33.6 °C, in 22.93 s, and showed the spreadability of 6.2 cm.
34013840	1	5	theme	gel	243:245	arg1	system					247:252	a thermoresponsive in situ gel system	216:252	a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS)	216:301	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	0	6	theme	thermoresponsive	66:81	arg1	F127-chitosan					103:115	thermoresponsive ophthalmic pluronic F127-chitosan	66:115	thermoresponsive ophthalmic pluronic F127-chitosan	66:115	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	4	7	theme	In	787:788	arg1	studies					796:802	In vitro studies	787:802	In vitro studies conducted for the optimized gel	787:834	In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution.
34013840	1	8	dep	in	235:236	arg1	situ					238:241	situ	238:241	situ	238:241	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	0	9	theme	F127-chitosan	103:115	arg1	assessment					52:61	in vitro assessment	43:61	in vitro assessment	43:61	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	0	9	theme	F127-chitosan	103:115	arg1	optimization					25:36	optimization	25:36	optimization	25:36	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	0	9	theme	F127-chitosan	103:115	arg1	development					12:22	Formulation development	0:22	Formulation development	0:22	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	2	10	theme	CS	535:536	arg1	concentration					511:523	the concentration	507:523	the concentration of PL and CS as independent variables	507:561	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	2	11	theme	gelation	584:591	arg1	temperature					593:603	gelation temperature	584:603	gelation temperature	584:603	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	0	12	theme	pluronic	94:101	arg1	F127-chitosan					103:115	thermoresponsive ophthalmic pluronic F127-chitosan	66:115	thermoresponsive ophthalmic pluronic F127-chitosan	66:115	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	4	13	dep	In	787:788	arg1	vitro					790:794	vitro	790:794	vitro	790:794	In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution.
34013840	2	14	dep	in	405:406	arg1	situ					408:411	situ	408:411	situ	408:411	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	1	15	theme	drug	389:392	arg1	release					374:380	the release	370:380	the release of the drug	370:392	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	0	16	dep	in	117:118	arg1	situ					120:123	situ	120:123	situ	120:123	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	1	17	theme	pluronic	265:272	arg1	PL					280:281	PL	280:281	PL	280:281	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	1	17	theme	pluronic	265:272	arg1	F127					274:277	pluronic F127	265:277	pluronic F127 (PL)	265:282	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	2	18	theme	2-factor-3-level	439:454	arg1	variables					637:645	dependent variables	627:645	dependent variables	627:645	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	2	18	theme	2-factor-3-level	439:454	arg1	design					487:492	a 2-factor-3-level central composite experimental design	437:492	a 2-factor-3-level central composite experimental design	437:492	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	3	19	from	22.5 g	694:699	arg1	22.93 s					738:744	22.93 s	738:744	22.93 s	738:744	The optimized formulation was developed using 22.5 g PL and 0.3 g CS, gels at 33.6 °C, in 22.93 s, and showed the spreadability of 6.2 cm.
34013840	5	20	with	model	1020:1024	arg1	transport					1049:1057	Fickian diffusion transport	1031:1057	Fickian diffusion transport	1031:1057	The mechanism of release of TCS followed the Higuchi model with Fickian diffusion transport.
34013840	6	21	theme	ocular	1168:1173	arg1	administration					1175:1188	ocular administration	1168:1188	ocular administration	1168:1188	Further, histopathology and HET-CAM studies revealed that the developed gel was non-irritating and safe for ocular administration.
34013840	1	22	theme	topical	178:184	arg1	delivery					186:193	topical delivery	178:193	topical delivery of tacrolimus (TCS)	178:213	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	0	23	theme	in	117:118	arg1	gel					136:138	in situ tacrolimus gel	117:138	in situ tacrolimus gel	117:138	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	2	24	theme	gelation	569:576	arg1	time					578:581	gelation time	569:581	gelation time	569:581	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	2	25	theme	dependent	627:635	arg1	variables					637:645	dependent variables	627:645	dependent variables	627:645	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	2	25	theme	dependent	627:635	arg1	design					487:492	a 2-factor-3-level central composite experimental design	437:492	a 2-factor-3-level central composite experimental design	437:492	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	5	26	theme	release	984:990	arg1	mechanism					971:979	The mechanism	967:979	The mechanism of release of TCS	967:997	The mechanism of release of TCS followed the Higuchi model with Fickian diffusion transport.
34013840	4	27	theme	TCS	870:872	arg1	release					859:865	the sustained release	845:865	the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h)	845:936	In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution.
34013840	0	28	theme	Formulation	0:10	arg1	development					12:22	Formulation development	0:22	Formulation development	0:22	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	5	29	theme	diffusion	1039:1047	arg1	transport					1049:1057	Fickian diffusion transport	1031:1057	Fickian diffusion transport	1031:1057	The mechanism of release of TCS followed the Higuchi model with Fickian diffusion transport.
34013840	6	30	theme	developed	1122:1130	arg1	non-irritating					1140:1153	non-irritating	1140:1153	non-irritating	1140:1153	Further, histopathology and HET-CAM studies revealed that the developed gel was non-irritating and safe for ocular administration.
34013840	6	30	theme	developed	1122:1130	arg1	gel					1132:1134	the developed gel	1118:1134	the developed gel	1118:1134	Further, histopathology and HET-CAM studies revealed that the developed gel was non-irritating and safe for ocular administration.
34013840	1	31	theme	tacrolimus	198:207	arg1	delivery					186:193	topical delivery	178:193	topical delivery of tacrolimus (TCS)	178:213	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	3	32	theme	0.3 g	708:712	arg1	22.5 g					694:699	22.5 g PL and 0.3 g CS	694:715	22.5 g PL and 0.3 g CS	694:715	The optimized formulation was developed using 22.5 g PL and 0.3 g CS, gels at 33.6 °C, in 22.93 s, and showed the spreadability of 6.2 cm.
34013840	3	32	theme	0.3 g	708:712	arg1	CS					714:715	0.3 g CS	708:715	0.3 g CS	708:715	The optimized formulation was developed using 22.5 g PL and 0.3 g CS, gels at 33.6 °C, in 22.93 s, and showed the spreadability of 6.2 cm.
34013840	5	33	theme	TCS	995:997	arg1	release					984:990	release	984:990	release of TCS	984:997	The mechanism of release of TCS followed the Higuchi model with Fickian diffusion transport.
34013840	0	34	theme	tacrolimus	125:134	arg1	gel					136:138	in situ tacrolimus gel	117:138	in situ tacrolimus gel	117:138	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	1	35	theme	precorneal	333:342	arg1	retention					344:352	the precorneal retention	329:352	the precorneal retention	329:352	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	4	36	theme	improved	894:901	arg1	permeation					911:920	improved corneal permeation	894:920	improved corneal permeation (74.13% in 4 h)	894:936	In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution.
34013840	4	37	dep	TCS	870:872	arg1	%					880:880	81.73%	875:880	81.73%	875:880	In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution.
34013840	4	38	theme	sustained	849:857	arg1	release					859:865	the sustained release	845:865	the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h)	845:936	In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution.
34013840	2	39	theme	in	405:406	arg1	gel					413:415	The PL-CS in situ gel	395:415	The PL-CS in situ gel	395:415	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	4	40	theme	corneal	903:909	arg1	permeation					911:920	improved corneal permeation	894:920	improved corneal permeation (74.13% in 4 h)	894:936	In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution.
34013840	2	41	theme	experimental	474:485	arg1	variables					637:645	dependent variables	627:645	dependent variables	627:645	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	2	41	theme	experimental	474:485	arg1	design					487:492	a 2-factor-3-level central composite experimental design	437:492	a 2-factor-3-level central composite experimental design	437:492	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	0	42	dep	in	43:44	arg1	vitro					46:50	vitro	46:50	vitro	46:50	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	2	43	theme	PL-CS	399:403	arg1	gel					413:415	The PL-CS in situ gel	395:415	The PL-CS in situ gel	395:415	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	2	44	theme	composite	464:472	arg1	variables					637:645	dependent variables	627:645	dependent variables	627:645	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	2	44	theme	composite	464:472	arg1	design					487:492	a 2-factor-3-level central composite experimental design	437:492	a 2-factor-3-level central composite experimental design	437:492	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	2	45	theme	PL	528:529	arg1	concentration					511:523	the concentration	507:523	the concentration of PL and CS as independent variables	507:561	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	4	46	from	%	928:928	arg1	4 h					933:935	4 h	933:935	4 h	933:935	In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution.
34013840	0	47	theme	in	43:44	arg1	assessment					52:61	in vitro assessment	43:61	in vitro assessment	43:61	Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel.
34013840	5	48	theme	Higuchi	1012:1018	arg1	model					1020:1024	the Higuchi model	1008:1024	the Higuchi model with Fickian diffusion transport	1008:1057	The mechanism of release of TCS followed the Higuchi model with Fickian diffusion transport.
34013840	3	49	theme	6.2 cm	779:784	arg1	spreadability					762:774	the spreadability	758:774	the spreadability of 6.2 cm	758:784	The optimized formulation was developed using 22.5 g PL and 0.3 g CS, gels at 33.6 °C, in 22.93 s, and showed the spreadability of 6.2 cm.
34013840	5	50	theme	Fickian	1031:1037	arg1	transport					1049:1057	Fickian diffusion transport	1031:1057	Fickian diffusion transport	1031:1057	The mechanism of release of TCS followed the Higuchi model with Fickian diffusion transport.
34013840	6	51	theme	HET-CAM	1088:1094	arg1	studies					1096:1102	histopathology and HET-CAM studies	1069:1102	histopathology and HET-CAM studies	1069:1102	Further, histopathology and HET-CAM studies revealed that the developed gel was non-irritating and safe for ocular administration.
34013840	4	52	theme	TCS	953:955	arg1	solution					957:964	TCS solution	953:964	TCS solution	953:964	In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution.
34013840	4	53	dep	permeation	911:920	arg1	%					928:928	74.13%	923:928	74.13%	923:928	In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution.
34013840	4	54	theme	optimized	822:830	arg1	gel					832:834	the optimized gel	818:834	the optimized gel	818:834	In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution.
34013840	1	55	contain	containing	254:263	arg2	PL					280:281	PL	280:281	PL	280:281	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	1	55	contain	containing	254:263	arg1	system					247:252	a thermoresponsive in situ gel system	216:252	a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS)	216:301	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	1	55	contain	containing	254:263	arg2	chitosan					289:296	chitosan	289:296	chitosan (CS)	289:301	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	1	55	contain	containing	254:263	arg2	CS					299:300	CS	299:300	CS	299:300	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	1	55	contain	containing	254:263	arg2	F127					274:277	pluronic F127	265:277	pluronic F127 (PL)	265:282	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	1	56	theme	thermoresponsive	218:233	arg1	system					247:252	a thermoresponsive in situ gel system	216:252	a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS)	216:301	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	6	57	theme	histopathology	1069:1082	arg1	studies					1096:1102	histopathology and HET-CAM studies	1069:1102	histopathology and HET-CAM studies	1069:1102	Further, histopathology and HET-CAM studies revealed that the developed gel was non-irritating and safe for ocular administration.
34013840	1	58	theme	in	235:236	arg1	system					247:252	a thermoresponsive in situ gel system	216:252	a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS)	216:301	To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, and to sustain the release of the drug.
34013840	4	59	theme	permeation	911:920	arg1	release					859:865	the sustained release	845:865	the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h)	845:936	In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution.
34013840	3	60	dep	22.5 g	694:699	arg1	22.5 g					694:699	22.5 g PL and 0.3 g CS	694:715	22.5 g PL and 0.3 g CS	694:715	The optimized formulation was developed using 22.5 g PL and 0.3 g CS, gels at 33.6 °C, in 22.93 s, and showed the spreadability of 6.2 cm.
34013840	3	60	dep	22.5 g	694:699	arg1	PL					701:702	PL	701:702	PL	701:702	The optimized formulation was developed using 22.5 g PL and 0.3 g CS, gels at 33.6 °C, in 22.93 s, and showed the spreadability of 6.2 cm.
34013840	3	60	dep	22.5 g	694:699	arg1	CS					714:715	0.3 g CS	708:715	0.3 g CS	708:715	The optimized formulation was developed using 22.5 g PL and 0.3 g CS, gels at 33.6 °C, in 22.93 s, and showed the spreadability of 6.2 cm.
34013840	4	61	from	%	880:880	arg1	4 h					885:887	4 h	885:887	4 h	885:887	In vitro studies conducted for the optimized gel revealed the sustained release of TCS (81.73% in 4 h) and improved corneal permeation (74.13% in 4 h), compared with TCS solution.
34013840	2	62	theme	central	456:462	arg1	variables					637:645	dependent variables	627:645	dependent variables	627:645	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34013840	2	62	theme	central	456:462	arg1	design					487:492	a 2-factor-3-level central composite experimental design	437:492	a 2-factor-3-level central composite experimental design	437:492	The PL-CS in situ gel was optimized using a 2-factor-3-level central composite experimental design by selecting the concentration of PL and CS as independent variables while gelation time, gelation temperature, and spreadability as dependent variables.
34420757	0	0	theme	nanofibrils	95:105	arg1	hydrogels					117:125	cation-induced cellulose nanofibrils composite hydrogels	70:125	cation-induced cellulose nanofibrils composite hydrogels	70:125	Revealing the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels.
34420757	4	1	theme	recovery	780:787	arg1	characteristics					789:803	enhanced recovery characteristics	771:803	enhanced recovery characteristics in the resulting hydrogels	771:830	These physically dual-crosslinked networks are strongly interwoven by non-sacrificial hydrogen bonds, this dual-crosslinked network leads to enhanced recovery characteristics in the resulting hydrogels.
34420757	1	2	theme	dual-crosslinked	167:182	arg1	hydrogels					200:208	physically dual-crosslinked cellulose-based hydrogels	156:208	physically dual-crosslinked cellulose-based hydrogels	156:208	In this study, we fabricate physically dual-crosslinked cellulose-based hydrogels by varying coordination bonding effects with the addition of either divalent or trivalent metal cations.
34420757	4	3	from	characteristics	789:803	arg1	hydrogels					822:830	the resulting hydrogels	808:830	the resulting hydrogels	808:830	These physically dual-crosslinked networks are strongly interwoven by non-sacrificial hydrogen bonds, this dual-crosslinked network leads to enhanced recovery characteristics in the resulting hydrogels.
34420757	4	4	theme	dual-crosslinked	647:662	arg1	networks					664:671	These physically dual-crosslinked networks	630:671	These physically dual-crosslinked networks	630:671	These physically dual-crosslinked networks are strongly interwoven by non-sacrificial hydrogen bonds, this dual-crosslinked network leads to enhanced recovery characteristics in the resulting hydrogels.
34420757	0	5	theme	cellulose	85:93	arg1	hydrogels					117:125	cation-induced cellulose nanofibrils composite hydrogels	70:125	cation-induced cellulose nanofibrils composite hydrogels	70:125	Revealing the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels.
34420757	5	6	dep	hydrogels	936:944	arg1	parameters					984:993	their structural deformation parameters	955:993	their structural deformation parameters	955:993	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	5	6	dep	hydrogels	936:944	arg1	the					932:934	the	932:934	the	932:934	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	1	7	theme	cellulose-based	184:198	arg1	hydrogels					200:208	physically dual-crosslinked cellulose-based hydrogels	156:208	physically dual-crosslinked cellulose-based hydrogels	156:208	In this study, we fabricate physically dual-crosslinked cellulose-based hydrogels by varying coordination bonding effects with the addition of either divalent or trivalent metal cations.
34420757	3	8	from	groups	601:606	arg1	alcohol					621:627	polyvinyl alcohol	611:627	polyvinyl alcohol	611:627	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	1	9	theme	trivalent	290:298	arg1	cations					306:312	either divalent or trivalent metal cations	271:312	either divalent or trivalent metal cations	271:312	In this study, we fabricate physically dual-crosslinked cellulose-based hydrogels by varying coordination bonding effects with the addition of either divalent or trivalent metal cations.
34420757	0	10	theme	hydrogels	117:125	arg1	mechanisms					56:65	the enhanced structural recovery and gelation mechanisms	10:65	the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels	10:125	Revealing the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels.
34420757	5	11	from	deformation	894:904	arg1	diagrams					1004:1011	phase diagrams	998:1011	phase diagrams	998:1011	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	2	12	theme	crosslinked	325:335	arg1	network					337:343	The first crosslinked network	315:343	The first crosslinked network	315:343	The first crosslinked network is created by metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundant carboxyl groups and the metal cations.
34420757	1	13	theme	metal	300:304	arg1	cations					306:312	either divalent or trivalent metal cations	271:312	either divalent or trivalent metal cations	271:312	In this study, we fabricate physically dual-crosslinked cellulose-based hydrogels by varying coordination bonding effects with the addition of either divalent or trivalent metal cations.
34420757	0	14	theme	composite	107:115	arg1	hydrogels					117:125	cation-induced cellulose nanofibrils composite hydrogels	70:125	cation-induced cellulose nanofibrils composite hydrogels	70:125	Revealing the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels.
34420757	5	15	from	diagrams	1004:1011	arg1	deformation					894:904	deformation	894:904	deformation	894:904	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	5	15	from	diagrams	1004:1011	arg1	behaviors					919:927	recovery behaviors	910:927	recovery behaviors	910:927	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	2	16	theme	cellulose	408:416	arg1	nanofibrils					418:428	the cellulose nanofibrils	404:428	the cellulose nanofibrils that have abundant carboxyl groups and the metal cations	404:485	The first crosslinked network is created by metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundant carboxyl groups and the metal cations.
34420757	1	17	theme	cations	306:312	arg1	addition					259:266	the addition	255:266	the addition of either divalent or trivalent metal cations	255:312	In this study, we fabricate physically dual-crosslinked cellulose-based hydrogels by varying coordination bonding effects with the addition of either divalent or trivalent metal cations.
34420757	5	18	theme	underlying	1031:1040	arg1	complexity					1042:1051	the underlying complexity	1027:1051	the underlying complexity of energy dissipation	1027:1073	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	5	19	theme	plot	950:953	arg1	deformation					894:904	deformation	894:904	deformation	894:904	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	5	19	theme	plot	950:953	arg1	behaviors					919:927	recovery behaviors	910:927	recovery behaviors	910:927	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	4	20	theme	hydrogen	716:723	arg1	bonds					725:729	non-sacrificial hydrogen bonds	700:729	non-sacrificial hydrogen bonds	700:729	These physically dual-crosslinked networks are strongly interwoven by non-sacrificial hydrogen bonds, this dual-crosslinked network leads to enhanced recovery characteristics in the resulting hydrogels.
34420757	5	21	theme	dual-crosslinked	1108:1123	arg1	hydrogels					1125:1133	the dual-crosslinked hydrogels	1104:1133	the dual-crosslinked hydrogels	1104:1133	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	3	22	theme	second	492:497	arg1	network					511:517	The second crosslinked network	488:517	The second crosslinked network	488:517	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	5	23	theme	recovery	910:917	arg1	behaviors					919:927	recovery behaviors	910:927	recovery behaviors	910:927	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	5	24	from	behaviors	919:927	arg1	diagrams					1004:1011	phase diagrams	998:1011	phase diagrams	998:1011	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	3	25	theme	hydroxyl	592:599	arg1	groups					601:606	the hydroxyl groups	588:606	the hydroxyl groups in polyvinyl alcohol	588:627	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	3	25	theme	hydroxyl	592:599	arg1	complex					576:582	tetra-functional borate ion complex	548:582	tetra-functional borate ion complex	548:582	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	2	26	theme	carboxyl	449:456	arg1	groups					458:463	abundant carboxyl groups	440:463	abundant carboxyl groups	440:463	The first crosslinked network is created by metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundant carboxyl groups and the metal cations.
34420757	3	27	from	reaction	536:543	arg1	alcohol					621:627	polyvinyl alcohol	611:627	polyvinyl alcohol	611:627	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	5	28	theme	dissipation	1063:1073	arg1	complexity					1042:1051	the underlying complexity	1027:1051	the underlying complexity of energy dissipation	1027:1073	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	5	28	theme	dissipation	1063:1073	arg1	dynamics					1092:1099	viscoelastic dynamics	1079:1099	viscoelastic dynamics of the dual-crosslinked hydrogels	1079:1133	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	5	29	from	hydrogels	936:944	arg1	diagrams					1004:1011	phase diagrams	998:1011	phase diagrams	998:1011	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	2	30	theme	abundant	440:447	arg1	groups					458:463	abundant carboxyl groups	440:463	abundant carboxyl groups	440:463	The first crosslinked network is created by metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundant carboxyl groups and the metal cations.
34420757	3	31	link	crosslinked	499:509	arg1	network					511:517	The second crosslinked network	488:517	The second crosslinked network	488:517	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	5	32	theme	deformation	972:982	arg1	parameters					984:993	their structural deformation parameters	955:993	their structural deformation parameters	955:993	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	1	33	theme	coordination	221:232	arg1	effects					242:248	coordination bonding effects	221:248	coordination bonding effects	221:248	In this study, we fabricate physically dual-crosslinked cellulose-based hydrogels by varying coordination bonding effects with the addition of either divalent or trivalent metal cations.
34420757	0	34	theme	structural	23:32	arg1	mechanisms					56:65	the enhanced structural recovery and gelation mechanisms	10:65	the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels	10:125	Revealing the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels.
34420757	1	35	link	dual-crosslinked	167:182	arg1	hydrogels					200:208	physically dual-crosslinked cellulose-based hydrogels	156:208	physically dual-crosslinked cellulose-based hydrogels	156:208	In this study, we fabricate physically dual-crosslinked cellulose-based hydrogels by varying coordination bonding effects with the addition of either divalent or trivalent metal cations.
34420757	5	36	theme	energy	1056:1061	arg1	dissipation					1063:1073	energy dissipation	1056:1073	energy dissipation	1056:1073	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	3	37	theme	polyvinyl	611:619	arg1	alcohol					621:627	polyvinyl alcohol	611:627	polyvinyl alcohol	611:627	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	5	38	theme	interval	846:853	arg1	testing					867:873	three interval thixotropic testing	840:873	three interval thixotropic testing	840:873	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	1	39	theme	bonding	234:240	arg1	effects					242:248	coordination bonding effects	221:248	coordination bonding effects	221:248	In this study, we fabricate physically dual-crosslinked cellulose-based hydrogels by varying coordination bonding effects with the addition of either divalent or trivalent metal cations.
34420757	0	40	theme	enhanced	14:21	arg1	mechanisms					56:65	the enhanced structural recovery and gelation mechanisms	10:65	the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels	10:125	Revealing the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels.
34420757	2	41	link	crosslinked	325:335	arg1	network					337:343	The first crosslinked network	315:343	The first crosslinked network	315:343	The first crosslinked network is created by metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundant carboxyl groups and the metal cations.
34420757	2	42	contain	have	435:438	arg2	cations					479:485	the metal cations	469:485	the metal cations	469:485	The first crosslinked network is created by metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundant carboxyl groups and the metal cations.
34420757	2	42	contain	have	435:438	arg2	groups					458:463	abundant carboxyl groups	440:463	abundant carboxyl groups	440:463	The first crosslinked network is created by metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundant carboxyl groups and the metal cations.
34420757	2	42	contain	have	435:438	arg1	nanofibrils					418:428	the cellulose nanofibrils	404:428	the cellulose nanofibrils that have abundant carboxyl groups and the metal cations	404:485	The first crosslinked network is created by metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundant carboxyl groups and the metal cations.
34420757	3	43	theme	ion	572:574	arg1	complex					576:582	tetra-functional borate ion complex	548:582	tetra-functional borate ion complex	548:582	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	4	44	theme	dual-crosslinked	737:752	arg1	network					754:760	this dual-crosslinked network	732:760	this dual-crosslinked network	732:760	These physically dual-crosslinked networks are strongly interwoven by non-sacrificial hydrogen bonds, this dual-crosslinked network leads to enhanced recovery characteristics in the resulting hydrogels.
34420757	2	45	theme	metal	473:477	arg1	cations					479:485	the metal cations	469:485	the metal cations	469:485	The first crosslinked network is created by metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundant carboxyl groups and the metal cations.
34420757	3	46	theme	borate	565:570	arg1	complex					576:582	tetra-functional borate ion complex	548:582	tetra-functional borate ion complex	548:582	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	5	47	theme	thixotropic	855:865	arg1	testing					867:873	three interval thixotropic testing	840:873	three interval thixotropic testing	840:873	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	5	48	theme	phase	998:1002	arg1	diagrams					1004:1011	phase diagrams	998:1011	phase diagrams	998:1011	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	0	49	theme	recovery	34:41	arg1	mechanisms					56:65	the enhanced structural recovery and gelation mechanisms	10:65	the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels	10:125	Revealing the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels.
34420757	5	50	theme	structural	961:970	arg1	parameters					984:993	their structural deformation parameters	955:993	their structural deformation parameters	955:993	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	5	51	link	dual-crosslinked	1108:1123	arg1	hydrogels					1125:1133	the dual-crosslinked hydrogels	1104:1133	the dual-crosslinked hydrogels	1104:1133	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	4	52	theme	resulting	812:820	arg1	hydrogels					822:830	the resulting hydrogels	808:830	the resulting hydrogels	808:830	These physically dual-crosslinked networks are strongly interwoven by non-sacrificial hydrogen bonds, this dual-crosslinked network leads to enhanced recovery characteristics in the resulting hydrogels.
34420757	0	53	theme	gelation	47:54	arg1	mechanisms					56:65	the enhanced structural recovery and gelation mechanisms	10:65	the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels	10:125	Revealing the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels.
34420757	4	54	link	dual-crosslinked	737:752	arg1	network					754:760	this dual-crosslinked network	732:760	this dual-crosslinked network	732:760	These physically dual-crosslinked networks are strongly interwoven by non-sacrificial hydrogen bonds, this dual-crosslinked network leads to enhanced recovery characteristics in the resulting hydrogels.
34420757	3	55	theme	tetra-functional	548:563	arg1	complex					576:582	tetra-functional borate ion complex	548:582	tetra-functional borate ion complex	548:582	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	5	56	from	plot	950:953	arg1	diagrams					1004:1011	phase diagrams	998:1011	phase diagrams	998:1011	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	2	57	theme	coordination	377:388	arg1	bonds					390:394	metal-carboxylate coordination bonds	359:394	metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundant carboxyl groups and the metal cations	359:485	The first crosslinked network is created by metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundant carboxyl groups and the metal cations.
34420757	5	58	theme	viscoelastic	1079:1090	arg1	dynamics					1092:1099	viscoelastic dynamics	1079:1099	viscoelastic dynamics of the dual-crosslinked hydrogels	1079:1133	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	5	59	theme	hydrogels	1125:1133	arg1	complexity					1042:1051	the underlying complexity	1027:1051	the underlying complexity of energy dissipation	1027:1073	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	5	59	theme	hydrogels	1125:1133	arg1	dynamics					1092:1099	viscoelastic dynamics	1079:1099	viscoelastic dynamics of the dual-crosslinked hydrogels	1079:1133	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	4	60	link	dual-crosslinked	647:662	arg1	networks					664:671	These physically dual-crosslinked networks	630:671	These physically dual-crosslinked networks	630:671	These physically dual-crosslinked networks are strongly interwoven by non-sacrificial hydrogen bonds, this dual-crosslinked network leads to enhanced recovery characteristics in the resulting hydrogels.
34420757	2	61	theme	metal-carboxylate	359:375	arg1	bonds					390:394	metal-carboxylate coordination bonds	359:394	metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundant carboxyl groups and the metal cations	359:485	The first crosslinked network is created by metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundant carboxyl groups and the metal cations.
34420757	0	62	theme	cation-induced	70:83	arg1	hydrogels					117:125	cation-induced cellulose nanofibrils composite hydrogels	70:125	cation-induced cellulose nanofibrils composite hydrogels	70:125	Revealing the enhanced structural recovery and gelation mechanisms of cation-induced cellulose nanofibrils composite hydrogels.
34420757	3	63	theme	complex	576:582	arg1	groups					601:606	the hydroxyl groups	588:606	the hydroxyl groups in polyvinyl alcohol	588:627	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	3	63	theme	complex	576:582	arg1	complex					576:582	tetra-functional borate ion complex	548:582	tetra-functional borate ion complex	548:582	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	3	63	theme	complex	576:582	arg1	reaction					536:543	the reaction	532:543	the reaction of tetra-functional borate ion complex	532:582	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	3	64	theme	crosslinked	499:509	arg1	network					511:517	The second crosslinked network	488:517	The second crosslinked network	488:517	The second crosslinked network is formed by the reaction of tetra-functional borate ion complex and the hydroxyl groups in polyvinyl alcohol.
34420757	4	65	theme	non-sacrificial	700:714	arg1	bonds					725:729	non-sacrificial hydrogen bonds	700:729	non-sacrificial hydrogen bonds	700:729	These physically dual-crosslinked networks are strongly interwoven by non-sacrificial hydrogen bonds, this dual-crosslinked network leads to enhanced recovery characteristics in the resulting hydrogels.
34420757	5	66	dep	deformation	894:904	arg1	the					890:892	the	890:892	the	890:892	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	5	67	theme	hydrogels	936:944	arg1	deformation					894:904	deformation	894:904	deformation	894:904	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	5	67	theme	hydrogels	936:944	arg1	behaviors					919:927	recovery behaviors	910:927	recovery behaviors	910:927	We use three interval thixotropic testing to investigate the deformation and recovery behaviors of the hydrogels and plot their structural deformation parameters in phase diagrams to understand the underlying complexity of energy dissipation and viscoelastic dynamics of the dual-crosslinked hydrogels.
34420757	4	68	theme	enhanced	771:778	arg1	characteristics					789:803	enhanced recovery characteristics	771:803	enhanced recovery characteristics in the resulting hydrogels	771:830	These physically dual-crosslinked networks are strongly interwoven by non-sacrificial hydrogen bonds, this dual-crosslinked network leads to enhanced recovery characteristics in the resulting hydrogels.
34420757	1	69	theme	divalent	278:285	arg1	cations					306:312	either divalent or trivalent metal cations	271:312	either divalent or trivalent metal cations	271:312	In this study, we fabricate physically dual-crosslinked cellulose-based hydrogels by varying coordination bonding effects with the addition of either divalent or trivalent metal cations.
34633751	1	0	theme	/chitosan/SiO2	421:434	arg1	nanoparticles					394:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles	361:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs)	361:439	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	0	theme	/chitosan/SiO2	421:434	arg1	NPs					436:438	Ru(bpy)3 2+ /chitosan/SiO2 NPs	409:438	Ru(bpy)3 2+ /chitosan/SiO2 NPs	409:438	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	1	theme	protein	300:306	arg1	PSA					335:337	PSA	335:337	PSA	335:337	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	1	theme	protein	300:306	arg1	antigen					326:332	tumour protein prostate specific antigen	293:332	tumour protein prostate specific antigen (PSA)	293:338	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	5	2	dep	NPs	1304:1306	arg1	provided					1308:1315	provided	1308:1315	NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan	1304:1429	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	8	3	theme	experimental	1770:1781	arg1	conditions					1783:1792	the optimized experimental conditions	1756:1792	the optimized experimental conditions	1756:1792	Under the optimized experimental conditions, the immunosensor displayed excellent sensitivity and selectivity.
34633751	1	4	theme	specific	317:324	arg1	PSA					335:337	PSA	335:337	PSA	335:337	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	4	theme	specific	317:324	arg1	antigen					326:332	tumour protein prostate specific antigen	293:332	tumour protein prostate specific antigen (PSA)	293:338	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	6	5	theme	/chitosan/SiO2	1497:1510	arg1	Ab2					1525:1527	Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2	1485:1527	Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2	1485:1527	After a sandwich immunoreaction, the PSA antigen and Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2 were sequentially captured onto the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface.
34633751	1	6	theme	novel	203:207	arg1	immunosensor					259:270	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor	201:270	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers	201:469	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	7	theme	signal	454:459	arg1	nanoparticles					394:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles	361:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs)	361:439	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	7	theme	signal	454:459	arg1	enhancers					461:469	the first signal enhancers	444:469	the first signal enhancers	444:469	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	8	theme	electrochemiluminescence	228:251	arg1	immunosensor					259:270	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor	201:270	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers	201:469	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	6	9	theme	bpy	1488:1490	arg1	Ab2					1525:1527	Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2	1485:1527	Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2	1485:1527	After a sandwich immunoreaction, the PSA antigen and Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2 were sequentially captured onto the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface.
34633751	1	10	theme	ECL	254:256	arg1	immunosensor					259:270	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor	201:270	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers	201:469	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	2	11	theme	forming	523:529	arg1	capacity					531:538	excellent pore forming capacity	508:538	excellent pore forming capacity	508:538	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	4	12	theme	Nafion/MWNTs	1147:1158	arg1	films					1160:1164	the unadorned Nafion/MWNTs films	1133:1164	the unadorned Nafion/MWNTs films	1133:1164	The chitosan-decorated Nafion/MWNTs composites exhibited a 5.5-times higher ECL intensity than the unadorned Nafion/MWNTs films.
34633751	3	13	theme	good	766:769	arg1	biocompatibility					771:786	good biocompatibility	766:786	good biocompatibility	766:786	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	0	14	theme	chitosan-decorated	145:162	arg1	composites					177:186	chitosan-decorated Nafion/MWNTs composites	145:186	chitosan-decorated Nafion/MWNTs composites	145:186	Novel dual-sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles as labels and chitosan-decorated Nafion/MWNTs composites as enhancer.
34633751	1	15	theme	Ru	409:410	arg1	nanoparticles					394:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles	361:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs)	361:439	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	15	theme	Ru	409:410	arg1	NPs					436:438	Ru(bpy)3 2+ /chitosan/SiO2 NPs	409:438	Ru(bpy)3 2+ /chitosan/SiO2 NPs	409:438	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	6	16	theme	electrode	1601:1609	arg1	surface					1611:1617	the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface	1561:1617	the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface	1561:1617	After a sandwich immunoreaction, the PSA antigen and Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2 were sequentially captured onto the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface.
34633751	7	17	theme	ECL	1624:1626	arg1	increases					1635:1643	The ECL signal increases	1620:1643	The ECL signal increases	1620:1643	The ECL signal increases were linearly related to the PSA antigen concentrations and ranged from 0.01 pg·mLl-1 to 10.0 pg·mLl-1 .
34633751	7	17	theme	ECL	1624:1626	arg1	related					1659:1665	related	1659:1665	related	1659:1665	The ECL signal increases were linearly related to the PSA antigen concentrations and ranged from 0.01 pg·mLl-1 to 10.0 pg·mLl-1 .
34633751	2	18	theme	porous	569:574	arg1	structures					576:585	porous structures	569:585	porous structures	569:585	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	2	19	theme	2+	692:693	arg1	NPs					701:703	Ru(bpy)3 2+ /SiO2 NPs	683:703	Ru(bpy)3 2+ /SiO2 NPs reported in previous publications	683:737	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	1	20	theme	bpy	412:414	arg1	nanoparticles					394:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles	361:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs)	361:439	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	20	theme	bpy	412:414	arg1	NPs					436:438	Ru(bpy)3 2+ /chitosan/SiO2 NPs	409:438	Ru(bpy)3 2+ /chitosan/SiO2 NPs	409:438	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	6	21	theme	Ab1	1565:1567	arg1	surface					1611:1617	the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface	1561:1617	the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface	1561:1617	After a sandwich immunoreaction, the PSA antigen and Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2 were sequentially captured onto the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface.
34633751	5	22	theme	2+	1286:1287	arg1	/chitosan/SiO2					1289:1302	the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2	1249:1302	the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2	1249:1302	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	0	23	theme	bpy	87:89	arg1	chitosan/SiO2					103:115	photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2	69:115	photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2	69:115	Novel dual-sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles as labels and chitosan-decorated Nafion/MWNTs composites as enhancer.
34633751	1	24	theme	Ru	361:362	arg1	chitosan/SiO2					380:392	Ru(bpy)3 2+ -doped chitosan/SiO2	361:392	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs)	361:439	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	3	25	theme	modified	900:907	arg1	surface					919:925	a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface	849:925	a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface	849:925	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	1	26	theme	bpy	364:366	arg1	chitosan/SiO2					380:392	Ru(bpy)3 2+ -doped chitosan/SiO2	361:392	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs)	361:439	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	3	27	with	chitosan	752:759	arg1	hydrophilicity					797:810	high hydrophilicity	792:810	high hydrophilicity	792:810	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	3	27	with	chitosan	752:759	arg1	biocompatibility					771:786	good biocompatibility	766:786	good biocompatibility	766:786	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	2	28	theme	excellent	508:516	arg1	capacity					531:538	excellent pore forming capacity	508:538	excellent pore forming capacity	508:538	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	2	29	contain	have	631:634	arg1	nanoparticles					547:559	these nanoparticles	541:559	these nanoparticles	541:559	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	2	29	contain	have	631:634	arg2	efficiencies					656:667	higher luminescence efficiencies	636:667	higher luminescence efficiencies	636:667	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	0	30	theme	-doped	96:101	arg1	chitosan/SiO2					103:115	photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2	69:115	photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2	69:115	Novel dual-sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles as labels and chitosan-decorated Nafion/MWNTs composites as enhancer.
34633751	9	31	dep	low	1888:1890	arg1	limit					1875:1879	The detection limit	1861:1879	The detection limit	1861:1879	The detection limit was as low as 3.4 fg·mLl-1 , equivalent to, or better than, those of the reported ECL immunosensors for PSA.
34633751	9	31	dep	low	1888:1890	arg1	low					1888:1890	low	1888:1890	low	1888:1890	The detection limit was as low as 3.4 fg·mLl-1 , equivalent to, or better than, those of the reported ECL immunosensors for PSA.
34633751	9	31	dep	low	1888:1890	arg1	those					1941:1945	those	1941:1945	those	1941:1945	The detection limit was as low as 3.4 fg·mLl-1 , equivalent to, or better than, those of the reported ECL immunosensors for PSA.
34633751	2	32	contain	possess	561:567	arg1	nanoparticles					547:559	these nanoparticles	541:559	these nanoparticles	541:559	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	2	32	contain	possess	561:567	arg2	photopermeability					598:614	better photopermeability	591:614	better photopermeability	591:614	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	2	32	contain	possess	561:567	arg2	structures					576:585	porous structures	569:585	porous structures	569:585	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	2	33	theme	higher	636:641	arg1	efficiencies					656:667	higher luminescence efficiencies	636:667	higher luminescence efficiencies	636:667	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	5	34	theme	active	1335:1340	arg1	arms					1342:1345	active arms	1335:1345	active arms	1335:1345	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	1	35	theme	-doped	373:378	arg1	chitosan/SiO2					380:392	Ru(bpy)3 2+ -doped chitosan/SiO2	361:392	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs)	361:439	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	2	36	with	chitosan	494:501	arg1	capacity					531:538	excellent pore forming capacity	508:538	excellent pore forming capacity	508:538	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	7	37	theme	antigen	1678:1684	arg1	concentrations					1686:1699	the PSA antigen concentrations	1670:1699	the PSA antigen concentrations	1670:1699	The ECL signal increases were linearly related to the PSA antigen concentrations and ranged from 0.01 pg·mLl-1 to 10.0 pg·mLl-1 .
34633751	0	38	theme	Novel	0:4	arg1	immunosensor					50:61	Novel dual-sensitization electrochemiluminescence immunosensor	0:61	Novel dual-sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2	0:115	Novel dual-sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles as labels and chitosan-decorated Nafion/MWNTs composites as enhancer.
34633751	1	39	theme	antigen	326:332	arg1	detection					280:288	the detection	276:288	the detection of tumour protein prostate specific antigen (PSA) at trace level	276:353	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	3	40	theme	sensitizing	950:960	arg1	chitosan					752:759	chitosan	752:759	chitosan with good biocompatibility and high hydrophilicity	752:810	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	3	40	theme	sensitizing	950:960	arg1	matrix					962:967	the second sensitizing matrix	939:967	the second sensitizing matrix	939:967	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	4	41	theme	Nafion/MWNTs	1061:1072	arg1	composites					1074:1083	The chitosan-decorated Nafion/MWNTs composites	1038:1083	The chitosan-decorated Nafion/MWNTs composites	1038:1083	The chitosan-decorated Nafion/MWNTs composites exhibited a 5.5-times higher ECL intensity than the unadorned Nafion/MWNTs films.
34633751	0	42	theme	electrochemiluminescence	25:48	arg1	immunosensor					50:61	Novel dual-sensitization electrochemiluminescence immunosensor	0:61	Novel dual-sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2	0:115	Novel dual-sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles as labels and chitosan-decorated Nafion/MWNTs composites as enhancer.
34633751	5	43	theme	3-aminopropyl	1211:1223	arg1	APTS					1242:1245	APTS	1242:1245	APTS	1242:1245	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	5	43	theme	3-aminopropyl	1211:1223	arg1	triethoxysilane					1225:1239	(3-aminopropyl)triethoxysilane	1210:1239	(3-aminopropyl)triethoxysilane (APTS)	1210:1246	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	9	44	theme	detection	1865:1873	arg1	limit					1875:1879	The detection limit	1861:1879	The detection limit	1861:1879	The detection limit was as low as 3.4 fg·mLl-1 , equivalent to, or better than, those of the reported ECL immunosensors for PSA.
34633751	9	44	theme	detection	1865:1873	arg1	low					1888:1890	low	1888:1890	low	1888:1890	The detection limit was as low as 3.4 fg·mLl-1 , equivalent to, or better than, those of the reported ECL immunosensors for PSA.
34633751	9	44	theme	detection	1865:1873	arg1	those					1941:1945	those	1941:1945	those	1941:1945	The detection limit was as low as 3.4 fg·mLl-1 , equivalent to, or better than, those of the reported ECL immunosensors for PSA.
34633751	5	45	theme	additional	1181:1190	arg1	triethoxysilane					1225:1239	(3-aminopropyl)triethoxysilane	1210:1239	(3-aminopropyl)triethoxysilane (APTS)	1210:1246	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	5	45	theme	additional	1181:1190	arg1	reagents					1192:1199	additional reagents	1181:1199	additional reagents	1181:1199	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	3	46	theme	large	978:982	arg1	Ab1					1031:1033	Ab1	1031:1033	Ab1	1031:1033	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	3	46	theme	large	978:982	arg1	antibody					1021:1028	prostate specific capture antibody	995:1028	prostate specific capture antibody (Ab1 )	995:1035	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	3	46	theme	large	978:982	arg1	amounts					984:990	large amounts	978:990	large amounts of prostate specific capture antibody (Ab1 )	978:1035	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	0	47	theme	Ru	84:85	arg1	chitosan/SiO2					103:115	photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2	69:115	photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2	69:115	Novel dual-sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles as labels and chitosan-decorated Nafion/MWNTs composites as enhancer.
34633751	4	48	theme	ECL	1114:1116	arg1	intensity					1118:1126	a 5.5-times higher ECL intensity	1095:1126	a 5.5-times higher ECL intensity than the unadorned Nafion/MWNTs films	1095:1164	The chitosan-decorated Nafion/MWNTs composites exhibited a 5.5-times higher ECL intensity than the unadorned Nafion/MWNTs films.
34633751	3	49	theme	specific	1004:1011	arg1	Ab1					1031:1033	Ab1	1031:1033	Ab1	1031:1033	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	3	49	theme	specific	1004:1011	arg1	antibody					1021:1028	prostate specific capture antibody	995:1028	prostate specific capture antibody (Ab1 )	995:1035	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	6	50	theme	PSA	1469:1471	arg1	antigen					1473:1479	the PSA antigen	1465:1479	the PSA antigen	1465:1479	After a sandwich immunoreaction, the PSA antigen and Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2 were sequentially captured onto the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface.
34633751	5	51	theme	one-step	1253:1260	arg1	/chitosan/SiO2					1289:1302	the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2	1249:1302	the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2	1249:1302	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	9	52	theme	equivalent	1910:1919	arg1	3.4 fg·mLl-1					1895:1906	3.4 fg·mLl-1	1895:1906	3.4 fg·mLl-1	1895:1906	The detection limit was as low as 3.4 fg·mLl-1 , equivalent to, or better than, those of the reported ECL immunosensors for PSA.
34633751	1	53	from	level	349:353	arg1	detection					280:288	the detection	276:288	the detection of tumour protein prostate specific antigen (PSA) at trace level	276:353	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	54	theme	tumour	293:298	arg1	PSA					335:337	PSA	335:337	PSA	335:337	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	54	theme	tumour	293:298	arg1	antigen					326:332	tumour protein prostate specific antigen	293:332	tumour protein prostate specific antigen (PSA)	293:338	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	2	55	theme	better	591:596	arg1	photopermeability					598:614	better photopermeability	591:614	better photopermeability	591:614	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	1	56	theme	first	448:452	arg1	nanoparticles					394:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles	361:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs)	361:439	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	56	theme	first	448:452	arg1	enhancers					461:469	the first signal enhancers	444:469	the first signal enhancers	444:469	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	6	57	theme	sandwich	1440:1447	arg1	immunoreaction					1449:1462	a sandwich immunoreaction	1438:1462	a sandwich immunoreaction	1438:1462	After a sandwich immunoreaction, the PSA antigen and Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2 were sequentially captured onto the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface.
34633751	1	58	theme	prostate	308:315	arg1	PSA					335:337	PSA	335:337	PSA	335:337	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	58	theme	prostate	308:315	arg1	antigen					326:332	tumour protein prostate specific antigen	293:332	tumour protein prostate specific antigen (PSA)	293:338	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	3	59	theme	antibody	1021:1028	arg1	Ab1					1031:1033	Ab1	1031:1033	Ab1	1031:1033	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	3	59	theme	antibody	1021:1028	arg1	antibody					1021:1028	prostate specific capture antibody	995:1028	prostate specific capture antibody (Ab1 )	995:1035	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	3	59	theme	antibody	1021:1028	arg1	amounts					984:990	large amounts	978:990	large amounts of prostate specific capture antibody (Ab1 )	978:1035	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	6	60	theme	NPs-labelled	1512:1523	arg1	Ab2					1525:1527	Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2	1485:1527	Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2	1485:1527	After a sandwich immunoreaction, the PSA antigen and Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2 were sequentially captured onto the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface.
34633751	5	61	theme	amino	1406:1410	arg1	groups					1412:1417	the amino groups	1402:1417	the amino groups in chitosan	1402:1429	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	6	62	theme	2+	1494:1495	arg1	Ab2					1525:1527	Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2	1485:1527	Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2	1485:1527	After a sandwich immunoreaction, the PSA antigen and Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2 were sequentially captured onto the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface.
34633751	1	63	theme	dual-sensitization	209:226	arg1	immunosensor					259:270	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor	201:270	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers	201:469	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	4	64	theme	unadorned	1137:1145	arg1	films					1160:1164	the unadorned Nafion/MWNTs films	1133:1164	the unadorned Nafion/MWNTs films	1133:1164	The chitosan-decorated Nafion/MWNTs composites exhibited a 5.5-times higher ECL intensity than the unadorned Nafion/MWNTs films.
34633751	7	65	theme	signal	1628:1633	arg1	increases					1635:1643	The ECL signal increases	1620:1643	The ECL signal increases	1620:1643	The ECL signal increases were linearly related to the PSA antigen concentrations and ranged from 0.01 pg·mLl-1 to 10.0 pg·mLl-1 .
34633751	7	65	theme	signal	1628:1633	arg1	related					1659:1665	related	1659:1665	related	1659:1665	The ECL signal increases were linearly related to the PSA antigen concentrations and ranged from 0.01 pg·mLl-1 to 10.0 pg·mLl-1 .
34633751	9	66	theme	reported	1954:1961	arg1	immunosensors					1967:1979	the reported ECL immunosensors	1950:1979	the reported ECL immunosensors for PSA	1950:1987	The detection limit was as low as 3.4 fg·mLl-1 , equivalent to, or better than, those of the reported ECL immunosensors for PSA.
34633751	0	67	theme	Nafion/MWNTs	164:175	arg1	composites					177:186	chitosan-decorated Nafion/MWNTs composites	145:186	chitosan-decorated Nafion/MWNTs composites	145:186	Novel dual-sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles as labels and chitosan-decorated Nafion/MWNTs composites as enhancer.
34633751	2	68	theme	pore	518:521	arg1	capacity					531:538	excellent pore forming capacity	508:538	excellent pore forming capacity	508:538	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	2	69	theme	/SiO2	695:699	arg1	NPs					701:703	Ru(bpy)3 2+ /SiO2 NPs	683:703	Ru(bpy)3 2+ /SiO2 NPs reported in previous publications	683:737	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	6	70	theme	/chitosan/Nafion/MWNTs-modified	1569:1599	arg1	surface					1611:1617	the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface	1561:1617	the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface	1561:1617	After a sandwich immunoreaction, the PSA antigen and Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2 were sequentially captured onto the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface.
34633751	2	71	theme	previous	717:724	arg1	publications					726:737	previous publications	717:737	previous publications	717:737	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	1	72	theme	2+	418:419	arg1	nanoparticles					394:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles	361:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs)	361:439	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	72	theme	2+	418:419	arg1	NPs					436:438	Ru(bpy)3 2+ /chitosan/SiO2 NPs	409:438	Ru(bpy)3 2+ /chitosan/SiO2 NPs	409:438	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	5	73	theme	Ru	1277:1278	arg1	/chitosan/SiO2					1289:1302	the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2	1249:1302	the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2	1249:1302	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	3	74	theme	high	792:795	arg1	hydrophilicity					797:810	high hydrophilicity	792:810	high hydrophilicity	792:810	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	0	75	theme	2+	93:94	arg1	chitosan/SiO2					103:115	photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2	69:115	photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2	69:115	Novel dual-sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles as labels and chitosan-decorated Nafion/MWNTs composites as enhancer.
34633751	8	76	theme	excellent	1822:1830	arg1	sensitivity					1832:1842	excellent sensitivity	1822:1842	excellent sensitivity	1822:1842	Under the optimized experimental conditions, the immunosensor displayed excellent sensitivity and selectivity.
34633751	3	77	theme	electrode	909:917	arg1	surface					919:925	a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface	849:925	a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface	849:925	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	5	78	theme	bpy	1280:1282	arg1	/chitosan/SiO2					1289:1302	the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2	1249:1302	the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2	1249:1302	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	2	79	theme	luminescence	643:654	arg1	efficiencies					656:667	higher luminescence efficiencies	636:667	higher luminescence efficiencies	636:667	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	8	80	theme	optimized	1760:1768	arg1	conditions					1783:1792	the optimized experimental conditions	1756:1792	the optimized experimental conditions	1756:1792	Under the optimized experimental conditions, the immunosensor displayed excellent sensitivity and selectivity.
34633751	1	81	theme	2+	370:371	arg1	chitosan/SiO2					380:392	Ru(bpy)3 2+ -doped chitosan/SiO2	361:392	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs)	361:439	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	5	82	theme	arms	1342:1345	arg1	number					1325:1330	a large number	1317:1330	a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan	1317:1429	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	0	83	theme	dual-sensitization	6:23	arg1	immunosensor					50:61	Novel dual-sensitization electrochemiluminescence immunosensor	0:61	Novel dual-sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2	0:115	Novel dual-sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles as labels and chitosan-decorated Nafion/MWNTs composites as enhancer.
34633751	1	84	theme	chitosan/SiO2	380:392	arg1	nanoparticles					394:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles	361:406	Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs)	361:439	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	84	theme	chitosan/SiO2	380:392	arg1	NPs					436:438	Ru(bpy)3 2+ /chitosan/SiO2 NPs	409:438	Ru(bpy)3 2+ /chitosan/SiO2 NPs	409:438	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	1	84	theme	chitosan/SiO2	380:392	arg1	enhancers					461:469	the first signal enhancers	444:469	the first signal enhancers	444:469	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	2	85	theme	Ru	683:684	arg1	NPs					701:703	Ru(bpy)3 2+ /SiO2 NPs	683:703	Ru(bpy)3 2+ /SiO2 NPs reported in previous publications	683:737	Due to chitosan with excellent pore forming capacity, these nanoparticles possess porous structures and better photopermeability, and therefore have higher luminescence efficiencies compared with Ru(bpy)3 2+ /SiO2 NPs reported in previous publications.
34633751	3	86	used	used	931:934	arg2	matrix					962:967	the second sensitizing matrix	939:967	the second sensitizing matrix	939:967	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	3	86	used	used	931:934	arg2	chitosan					752:759	chitosan	752:759	chitosan with good biocompatibility and high hydrophilicity	752:810	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	7	87	theme	PSA	1674:1676	arg1	concentrations					1686:1699	the PSA antigen concentrations	1670:1699	the PSA antigen concentrations	1670:1699	The ECL signal increases were linearly related to the PSA antigen concentrations and ranged from 0.01 pg·mLl-1 to 10.0 pg·mLl-1 .
34633751	4	88	theme	chitosan-decorated	1042:1059	arg1	composites					1074:1083	The chitosan-decorated Nafion/MWNTs composites	1038:1083	The chitosan-decorated Nafion/MWNTs composites	1038:1083	The chitosan-decorated Nafion/MWNTs composites exhibited a 5.5-times higher ECL intensity than the unadorned Nafion/MWNTs films.
34633751	9	89	theme	ECL	1963:1965	arg1	immunosensors					1967:1979	the reported ECL immunosensors	1950:1979	the reported ECL immunosensors for PSA	1950:1987	The detection limit was as low as 3.4 fg·mLl-1 , equivalent to, or better than, those of the reported ECL immunosensors for PSA.
34633751	5	90	theme	large	1319:1323	arg1	number					1325:1330	a large number	1317:1330	a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan	1317:1429	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	0	91	theme	photopermeable	69:82	arg1	chitosan/SiO2					103:115	photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2	69:115	photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2	69:115	Novel dual-sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles as labels and chitosan-decorated Nafion/MWNTs composites as enhancer.
34633751	3	92	theme	second	943:948	arg1	chitosan					752:759	chitosan	752:759	chitosan with good biocompatibility and high hydrophilicity	752:810	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	3	92	theme	second	943:948	arg1	matrix					962:967	the second sensitizing matrix	939:967	the second sensitizing matrix	939:967	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	1	93	theme	trace	343:347	arg1	level					349:353	trace level	343:353	trace level	343:353	A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy)3 2+ -doped chitosan/SiO2 nanoparticles (Ru(bpy)3 2+ /chitosan/SiO2 NPs) as the first signal enhancers was fabricated.
34633751	5	94	from	groups	1412:1417	arg1	chitosan					1422:1429	chitosan	1422:1429	chitosan	1422:1429	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	6	95	theme	Ru	1485:1486	arg1	Ab2					1525:1527	Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2	1485:1527	Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2	1485:1527	After a sandwich immunoreaction, the PSA antigen and Ru(bpy)3 2+ /chitosan/SiO2 NPs-labelled Ab2 were sequentially captured onto the Ab1 /chitosan/Nafion/MWNTs-modified electrode surface.
34633751	4	96	theme	higher	1107:1112	arg1	intensity					1118:1126	a 5.5-times higher ECL intensity	1095:1126	a 5.5-times higher ECL intensity than the unadorned Nafion/MWNTs films	1095:1164	The chitosan-decorated Nafion/MWNTs composites exhibited a 5.5-times higher ECL intensity than the unadorned Nafion/MWNTs films.
34633751	3	97	theme	capture	1013:1019	arg1	Ab1					1031:1033	Ab1	1031:1033	Ab1	1031:1033	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	3	97	theme	capture	1013:1019	arg1	antibody					1021:1028	prostate specific capture antibody	995:1028	prostate specific capture antibody (Ab1 )	995:1035	Conversely, chitosan with good biocompatibility and high hydrophilicity was electrochemically decorated onto a Nafion/multiwall carbon nanotubes (Nafion/MWNTs) modified electrode surface and used as the second sensitizing matrix to seize large amounts of prostate specific capture antibody (Ab1 ).
34633751	5	98	theme	PSA-detected	1363:1374	arg1	Ab2					1388:1390	Ab2	1388:1390	Ab2	1388:1390	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	5	98	theme	PSA-detected	1363:1374	arg1	antibodies					1376:1385	PSA-detected antibodies	1363:1385	PSA-detected antibodies (Ab2 )	1363:1392	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
34633751	5	99	theme	functionalized	1262:1275	arg1	/chitosan/SiO2					1289:1302	the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2	1249:1302	the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2	1249:1302	Also, without additional reagents, such as (3-aminopropyl)triethoxysilane (APTS), the one-step functionalized Ru(bpy)3 2+ /chitosan/SiO2 NPs provided a large number of active arms to connect with PSA-detected antibodies (Ab2 ) through the amino groups in chitosan.
32598156	0	0	theme	Cells	108:112	arg1	Capable					80:86	Capable	80:86	Capable	80:86	High-Order Assembly toward Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells.
32598156	5	1	theme	electrostatic-attraction-induced	1088:1119	arg1	assembly					1132:1139	electrostatic-attraction-induced high-order assembly	1088:1139	electrostatic-attraction-induced high-order assembly	1088:1139	Therefore, this study provides a reliable approach for the efficient loading of macromolecular payloads into complex coacervate nanodroplets via electrostatic-attraction-induced high-order assembly.
32598156	5	2	theme	reliable	976:983	arg1	approach					985:992	a reliable approach	974:992	a reliable approach for the efficient loading of macromolecular payloads into complex coacervate nanodroplets	974:1082	Therefore, this study provides a reliable approach for the efficient loading of macromolecular payloads into complex coacervate nanodroplets via electrostatic-attraction-induced high-order assembly.
32598156	0	3	theme	Cancer	101:106	arg1	Cells					108:112	Targeting Cancer Cells	91:112	Targeting Cancer Cells	91:112	High-Order Assembly toward Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells.
32598156	1	4	theme	living	180:185	arg1	organisms					187:195	living organisms	180:195	living organisms containing a large number of biomacromolecules	180:242	High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency.
32598156	4	5	theme	tumor	860:864	arg1	cells					866:870	CD44-overexpressed tumor cells	841:870	CD44-overexpressed tumor cells	841:870	HA in the assemblies is capable of targeting CD44-overexpressed tumor cells through CD44-mediated endocytic pathways, which are elucidated herein.
32598156	5	6	theme	complex	1052:1058	arg1	nanodroplets					1071:1082	complex coacervate nanodroplets	1052:1082	complex coacervate nanodroplets	1052:1082	Therefore, this study provides a reliable approach for the efficient loading of macromolecular payloads into complex coacervate nanodroplets via electrostatic-attraction-induced high-order assembly.
32598156	5	7	theme	high-order	1121:1130	arg1	assembly					1132:1139	electrostatic-attraction-induced high-order assembly	1088:1139	electrostatic-attraction-induced high-order assembly	1088:1139	Therefore, this study provides a reliable approach for the efficient loading of macromolecular payloads into complex coacervate nanodroplets via electrostatic-attraction-induced high-order assembly.
32598156	5	8	theme	coacervate	1060:1069	arg1	nanodroplets					1071:1082	complex coacervate nanodroplets	1052:1082	complex coacervate nanodroplets	1052:1082	Therefore, this study provides a reliable approach for the efficient loading of macromolecular payloads into complex coacervate nanodroplets via electrostatic-attraction-induced high-order assembly.
32598156	1	9	theme	nanomaterials	286:298	arg1	construction					270:281	the construction	266:281	the construction of nanomaterials that can load macromolecular payloads at a high efficiency	266:357	High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency.
32598156	4	10	theme	CD44-overexpressed	841:858	arg1	cells					866:870	CD44-overexpressed tumor cells	841:870	CD44-overexpressed tumor cells	841:870	HA in the assemblies is capable of targeting CD44-overexpressed tumor cells through CD44-mediated endocytic pathways, which are elucidated herein.
32598156	1	11	theme	organisms	187:195	arg1	formation					167:175	the formation	163:175	the formation of living organisms containing a large number of biomacromolecules	163:242	High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency.
32598156	3	12	theme	biological	770:779	arg1	functionality					781:793	biological functionality	770:793	biological functionality	770:793	The resultant assemblies were primarily composed of HA and cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels and had a controllable structure while also exhibiting biological functionality.
32598156	0	13	theme	High-Order	0:9	arg1	Assembly					11:18	High-Order Assembly	0:18	High-Order Assembly	0:18	High-Order Assembly toward Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells.
32598156	1	14	theme	High-order	115:124	arg1	assembly					126:133	High-order assembly	115:133	High-order assembly	115:133	High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency.
32598156	1	15	theme	large	210:214	arg1	number					216:221	a large number	208:221	a large number of biomacromolecules	208:242	High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency.
32598156	0	16	theme	Polysaccharide-Based	27:46	arg1	Nanodroplets					67:78	Polysaccharide-Based Complex Coacervate Nanodroplets	27:78	Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells	27:112	High-Order Assembly toward Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells.
32598156	4	17	theme	CD44-mediated	880:892	arg1	pathways					904:911	CD44-mediated endocytic pathways	880:911	CD44-mediated endocytic pathways	880:911	HA in the assemblies is capable of targeting CD44-overexpressed tumor cells through CD44-mediated endocytic pathways, which are elucidated herein.
32598156	5	18	theme	payloads	1038:1045	arg1	loading					1012:1018	the efficient loading	998:1018	the efficient loading of macromolecular payloads into complex coacervate nanodroplets	998:1082	Therefore, this study provides a reliable approach for the efficient loading of macromolecular payloads into complex coacervate nanodroplets via electrostatic-attraction-induced high-order assembly.
32598156	5	19	theme	macromolecular	1023:1036	arg1	payloads					1038:1045	macromolecular payloads	1023:1045	macromolecular payloads	1023:1045	Therefore, this study provides a reliable approach for the efficient loading of macromolecular payloads into complex coacervate nanodroplets via electrostatic-attraction-induced high-order assembly.
32598156	3	20	theme	resultant	599:607	arg1	assemblies					609:618	The resultant assemblies	595:618	The resultant assemblies	595:618	The resultant assemblies were primarily composed of HA and cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels and had a controllable structure while also exhibiting biological functionality.
32598156	2	21	theme	electrostatic-interaction-induced	453:485	arg1	assembly					498:505	the electrostatic-interaction-induced high-order assembly	449:505	the electrostatic-interaction-induced high-order assembly	449:505	Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets.
32598156	2	22	theme	model	414:418	arg1	acid					399:402	anionic hyaluronic acid	380:402	anionic hyaluronic acid (HA)	380:407	Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets.
32598156	2	22	theme	model	414:418	arg1	payload					420:426	a model payload	412:426	a model payload	412:426	Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets.
32598156	0	23	theme	Coacervate	56:65	arg1	Nanodroplets					67:78	Polysaccharide-Based Complex Coacervate Nanodroplets	27:78	Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells	27:112	High-Order Assembly toward Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells.
32598156	1	24	theme	macromolecular	314:327	arg1	payloads					329:336	macromolecular payloads	314:336	macromolecular payloads	314:336	High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency.
32598156	2	25	theme	coacervate	570:579	arg1	nanodroplets					581:592	complex coacervate nanodroplets	562:592	complex coacervate nanodroplets	562:592	Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets.
32598156	1	26	theme	biomacromolecules	226:242	arg1	number					216:221	a large number	208:221	a large number of biomacromolecules	208:242	High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency.
32598156	0	27	theme	Complex	48:54	arg1	Nanodroplets					67:78	Polysaccharide-Based Complex Coacervate Nanodroplets	27:78	Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells	27:112	High-Order Assembly toward Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells.
32598156	2	28	theme	high-order	487:496	arg1	assembly					498:505	the electrostatic-interaction-induced high-order assembly	449:505	the electrostatic-interaction-induced high-order assembly	449:505	Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets.
32598156	1	29	contain	containing	197:206	arg1	organisms					187:195	living organisms	180:195	living organisms containing a large number of biomacromolecules	180:242	High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency.
32598156	1	29	contain	containing	197:206	arg2	number					216:221	a large number	208:221	a large number of biomacromolecules	208:242	High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency.
32598156	4	30	theme	endocytic	894:902	arg1	pathways					904:911	CD44-mediated endocytic pathways	880:911	CD44-mediated endocytic pathways	880:911	HA in the assemblies is capable of targeting CD44-overexpressed tumor cells through CD44-mediated endocytic pathways, which are elucidated herein.
32598156	0	31	theme	Capable	80:86	arg1	Nanodroplets					67:78	Polysaccharide-Based Complex Coacervate Nanodroplets	27:78	Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells	27:112	High-Order Assembly toward Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells.
32598156	3	32	theme	COS/Dex	697:703	arg1	nanogels					706:713	cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels	654:713	cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels	654:713	The resultant assemblies were primarily composed of HA and cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels and had a controllable structure while also exhibiting biological functionality.
32598156	2	33	theme	complex	562:568	arg1	nanodroplets					581:592	complex coacervate nanodroplets	562:592	complex coacervate nanodroplets	562:592	Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets.
32598156	1	34	theme	significant	143:153	arg1	role					155:158	a significant role	141:158	a significant role	141:158	High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency.
32598156	4	35	from	HA	796:797	arg1	assemblies					806:815	the assemblies	802:815	the assemblies	802:815	HA in the assemblies is capable of targeting CD44-overexpressed tumor cells through CD44-mediated endocytic pathways, which are elucidated herein.
32598156	1	36	theme	high	343:346	arg1	efficiency					348:357	a high efficiency	341:357	a high efficiency	341:357	High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency.
32598156	3	37	theme	controllable	725:736	arg1	structure					738:746	a controllable structure	723:746	a controllable structure	723:746	The resultant assemblies were primarily composed of HA and cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels and had a controllable structure while also exhibiting biological functionality.
32598156	3	38	theme	chitosan	663:670	arg1	nanogels					706:713	cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels	654:713	cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels	654:713	The resultant assemblies were primarily composed of HA and cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels and had a controllable structure while also exhibiting biological functionality.
32598156	5	39	theme	efficient	1002:1010	arg1	loading					1012:1018	the efficient loading	998:1018	the efficient loading of macromolecular payloads into complex coacervate nanodroplets	998:1082	Therefore, this study provides a reliable approach for the efficient loading of macromolecular payloads into complex coacervate nanodroplets via electrostatic-attraction-induced high-order assembly.
32598156	2	40	used	used	514:517	arg2	assembly					498:505	the electrostatic-interaction-induced high-order assembly	449:505	the electrostatic-interaction-induced high-order assembly	449:505	Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets.
32598156	3	41	theme	oligosaccharide/dextran	672:694	arg1	nanogels					706:713	cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels	654:713	cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels	654:713	The resultant assemblies were primarily composed of HA and cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels and had a controllable structure while also exhibiting biological functionality.
32598156	2	42	theme	anionic	380:386	arg1	HA					405:406	HA	405:406	HA	405:406	Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets.
32598156	2	42	theme	anionic	380:386	arg1	acid					399:402	anionic hyaluronic acid	380:402	anionic hyaluronic acid (HA)	380:407	Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets.
32598156	2	42	theme	anionic	380:386	arg1	payload					420:426	a model payload	412:426	a model payload	412:426	Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets.
32598156	0	43	theme	Targeting	91:99	arg1	Cells					108:112	Targeting Cancer Cells	91:112	Targeting Cancer Cells	91:112	High-Order Assembly toward Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells.
32598156	0	44	dep	Assembly	11:18	arg1	Nanodroplets					67:78	Polysaccharide-Based Complex Coacervate Nanodroplets	27:78	Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells	27:112	High-Order Assembly toward Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells.
32598156	2	45	theme	hyaluronic	388:397	arg1	HA					405:406	HA	405:406	HA	405:406	Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets.
32598156	2	45	theme	hyaluronic	388:397	arg1	acid					399:402	anionic hyaluronic acid	380:402	anionic hyaluronic acid (HA)	380:407	Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets.
32598156	2	45	theme	hyaluronic	388:397	arg1	payload					420:426	a model payload	412:426	a model payload	412:426	Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used to load efficiently biomacromolecules into complex coacervate nanodroplets.
32598156	1	46	from	efficiency	348:357	arg1	load					309:312	load	309:312	load	309:312	High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency.
32598156	3	47	theme	cationic	654:661	arg1	nanogels					706:713	cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels	654:713	cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels	654:713	The resultant assemblies were primarily composed of HA and cationic chitosan oligosaccharide/dextran (COS/Dex) nanogels and had a controllable structure while also exhibiting biological functionality.
32598156	1	48	dep	plays	135:139	arg1	enlightens					255:264	enlightens	255:264	enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency	255:357	High-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency.
32718644	0	0	theme	drug	91:94	arg1	delivery					67:74	buccal delivery	60:74	buccal delivery of hydrophilic drug	60:94	Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug.
32718644	9	1	theme	drug	822:825	arg1	release					827:833	drug release	822:833	drug release	822:833	The film swelling and drug release decreased with the CS ratio.
32718644	1	2	theme	starch	174:179	arg1	characterization					117:132	characterization	117:132	characterization	117:132	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	1	2	theme	starch	174:179	arg1	fabrication					101:111	fabrication	101:111	fabrication	101:111	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	0	3	theme	hydrophilic	79:89	arg1	drug					91:94	hydrophilic drug	79:94	hydrophilic drug	79:94	Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug.
32718644	10	4	theme	MGRS	977:980	arg1	flux					965:968	the permeation flux	950:968	the permeation flux of 1:2 MGRS:CS composite	950:993	Drug permeation across porcine mucosa indicated the enhancement effect of CS, whereby the permeation flux of 1:2 MGRS:CS composite increased by 3 folds.
32718644	2	5	theme	film	288:291	arg1	properties					293:302	the film properties	284:302	the film properties	284:302	Effect of CS ratios (2:1, 1:1, 1:2 MGRS:CS) on the film properties was investigated.
32718644	7	6	theme	MGRS	667:670	arg1	films					672:676	MGRS films	667:676	MGRS films	667:676	The presence of CS did not affect the mucoadhesiveness of MGRS films.
32718644	9	7	theme	CS	854:855	arg1	ratio					857:861	the CS ratio	850:861	the CS ratio	850:861	The film swelling and drug release decreased with the CS ratio.
32718644	10	8	theme	enhancement	916:926	arg1	effect					928:933	the enhancement effect	912:933	the enhancement effect	912:933	Drug permeation across porcine mucosa indicated the enhancement effect of CS, whereby the permeation flux of 1:2 MGRS:CS composite increased by 3 folds.
32718644	6	9	theme	drug	556:559	arg1	contents					561:568	drug contents	556:568	drug contents	556:568	The uniform and comparable thickness, weight, and drug contents of all fabricated films were obtained.
32718644	8	10	dep	observed	767:774	arg1	films					793:797	CS films	790:797	CS films	790:797	The increase in tensile strength and decreases in elongation and folding endurance were observed with 1:2 MGRS:CS films.
32718644	11	11	theme	hydrophilic	1093:1103	arg1	drug					1105:1108	hydrophilic drug	1093:1108	hydrophilic drug	1093:1108	In conclusion, the MGRS:CS composite could be useful for buccal delivery of hydrophilic drug.
32718644	2	12	dep	1:1	263:265	arg1	CS					277:278	CS	277:278	CS	277:278	Effect of CS ratios (2:1, 1:1, 1:2 MGRS:CS) on the film properties was investigated.
32718644	8	13	from	increase	683:690	arg1	strength					703:710	tensile strength	695:710	tensile strength	695:710	The increase in tensile strength and decreases in elongation and folding endurance were observed with 1:2 MGRS:CS films.
32718644	8	13	from	increase	683:690	arg1	folding					744:750	folding	744:750	folding	744:750	The increase in tensile strength and decreases in elongation and folding endurance were observed with 1:2 MGRS:CS films.
32718644	8	13	from	increase	683:690	arg1	elongation					729:738	elongation	729:738	elongation	729:738	The increase in tensile strength and decreases in elongation and folding endurance were observed with 1:2 MGRS:CS films.
32718644	11	14	theme	CS	1041:1042	arg1	composite					1044:1052	CS composite	1041:1052	CS composite	1041:1052	In conclusion, the MGRS:CS composite could be useful for buccal delivery of hydrophilic drug.
32718644	3	15	theme	hydrophilic	366:376	arg1	hydrochloride					332:344	Lidocaine hydrochloride	322:344	Lidocaine hydrochloride	322:344	Lidocaine hydrochloride was used as a model hydrophilic drug.
32718644	3	15	theme	hydrophilic	366:376	arg1	drug					378:381	a model hydrophilic drug	358:381	a model hydrophilic drug	358:381	Lidocaine hydrochloride was used as a model hydrophilic drug.
32718644	0	16	theme	glutinous	9:17	arg1	rice					19:22	Modified glutinous rice	0:22	Modified glutinous rice	0:22	Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug.
32718644	10	17	theme	Drug	864:867	arg1	permeation					869:878	Drug permeation	864:878	Drug permeation across porcine mucosa	864:900	Drug permeation across porcine mucosa indicated the enhancement effect of CS, whereby the permeation flux of 1:2 MGRS:CS composite increased by 3 folds.
32718644	3	18	used	used	350:353	arg2	drug					378:381	a model hydrophilic drug	358:381	a model hydrophilic drug	358:381	Lidocaine hydrochloride was used as a model hydrophilic drug.
32718644	3	18	used	used	350:353	arg2	hydrochloride					332:344	Lidocaine hydrochloride	322:344	Lidocaine hydrochloride	322:344	Lidocaine hydrochloride was used as a model hydrophilic drug.
32718644	2	19	dep	ratios	250:255	arg1	2:1					258:260	2:1	258:260	2:1	258:260	Effect of CS ratios (2:1, 1:1, 1:2 MGRS:CS) on the film properties was investigated.
32718644	0	20	theme	Modified	0:7	arg1	rice					19:22	Modified glutinous rice	0:22	Modified glutinous rice	0:22	Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug.
32718644	10	21	theme	1:2	973:975	arg1	MGRS					977:980	1:2 MGRS	973:980	1:2 MGRS:CS composite	973:993	Drug permeation across porcine mucosa indicated the enhancement effect of CS, whereby the permeation flux of 1:2 MGRS:CS composite increased by 3 folds.
32718644	1	22	theme	chitosan	188:195	arg1	films					212:216	chitosan (CS) composite films	188:216	chitosan (CS) composite films	188:216	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	11	23	theme	drug	1105:1108	arg1	delivery					1081:1088	buccal delivery	1074:1088	buccal delivery of hydrophilic drug	1074:1108	In conclusion, the MGRS:CS composite could be useful for buccal delivery of hydrophilic drug.
32718644	2	24	theme	1:2	268:270	arg1	1:1					263:265	1:1	263:265	1:1	263:265	Effect of CS ratios (2:1, 1:1, 1:2 MGRS:CS) on the film properties was investigated.
32718644	2	24	theme	1:2	268:270	arg1	MGRS					272:275	1:2 MGRS	268:275	1:2 MGRS	268:275	Effect of CS ratios (2:1, 1:1, 1:2 MGRS:CS) on the film properties was investigated.
32718644	2	25	from	Effect	237:242	arg1	properties					293:302	the film properties	284:302	the film properties	284:302	Effect of CS ratios (2:1, 1:1, 1:2 MGRS:CS) on the film properties was investigated.
32718644	3	26	theme	Lidocaine	322:330	arg1	hydrochloride					332:344	Lidocaine hydrochloride	322:344	Lidocaine hydrochloride	322:344	Lidocaine hydrochloride was used as a model hydrophilic drug.
32718644	3	26	theme	Lidocaine	322:330	arg1	drug					378:381	a model hydrophilic drug	358:381	a model hydrophilic drug	358:381	Lidocaine hydrochloride was used as a model hydrophilic drug.
32718644	10	27	dep	3	1008:1008	arg1	folds					1010:1014	folds	1010:1014	folds	1010:1014	Drug permeation across porcine mucosa indicated the enhancement effect of CS, whereby the permeation flux of 1:2 MGRS:CS composite increased by 3 folds.
32718644	4	28	theme	hydrogen	403:410	arg1	formation					417:425	hydrogen bond formation	403:425	hydrogen bond formation between MGRS and CS	403:445	ATR-FTIR confirmed hydrogen bond formation between MGRS and CS.
32718644	1	29	theme	glutinous	159:167	arg1	MGRS					182:185	MGRS	182:185	MGRS	182:185	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	1	29	theme	glutinous	159:167	arg1	starch					174:179	ball-milling modified glutinous rice starch	137:179	ball-milling modified glutinous rice starch (MGRS)	137:186	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	8	30	theme	CS	790:791	arg1	films					793:797	CS films	790:797	CS films	790:797	The increase in tensile strength and decreases in elongation and folding endurance were observed with 1:2 MGRS:CS films.
32718644	11	31	dep	MGRS	1036:1039	arg1	conclusion					1020:1029	conclusion	1020:1029	conclusion	1020:1029	In conclusion, the MGRS:CS composite could be useful for buccal delivery of hydrophilic drug.
32718644	11	31	dep	MGRS	1036:1039	arg1	useful					1063:1068	useful	1063:1068	useful	1063:1068	In conclusion, the MGRS:CS composite could be useful for buccal delivery of hydrophilic drug.
32718644	0	32	theme	composite	40:48	arg1	films					50:54	composite films	40:54	composite films for buccal delivery of hydrophilic drug	40:94	Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug.
32718644	10	33	dep	MGRS	977:980	arg1	CS					982:983	CS	982:983	CS	982:983	Drug permeation across porcine mucosa indicated the enhancement effect of CS, whereby the permeation flux of 1:2 MGRS:CS composite increased by 3 folds.
32718644	3	34	theme	model	360:364	arg1	hydrochloride					332:344	Lidocaine hydrochloride	322:344	Lidocaine hydrochloride	322:344	Lidocaine hydrochloride was used as a model hydrophilic drug.
32718644	3	34	theme	model	360:364	arg1	drug					378:381	a model hydrophilic drug	358:381	a model hydrophilic drug	358:381	Lidocaine hydrochloride was used as a model hydrophilic drug.
32718644	7	35	theme	CS	625:626	arg1	presence					613:620	The presence	609:620	The presence of CS	609:626	The presence of CS did not affect the mucoadhesiveness of MGRS films.
32718644	10	36	theme	porcine	887:893	arg1	mucosa					895:900	porcine mucosa	887:900	porcine mucosa	887:900	Drug permeation across porcine mucosa indicated the enhancement effect of CS, whereby the permeation flux of 1:2 MGRS:CS composite increased by 3 folds.
32718644	5	37	theme	fabricated	488:497	arg1	films					499:503	all fabricated films	484:503	all fabricated films	484:503	XRD indicated an amorphous state of all fabricated films.
32718644	1	38	theme	composite	202:210	arg1	films					212:216	chitosan (CS) composite films	188:216	chitosan (CS) composite films	188:216	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	0	39	theme	buccal	60:65	arg1	delivery					67:74	buccal delivery	60:74	buccal delivery of hydrophilic drug	60:94	Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug.
32718644	9	40	theme	film	804:807	arg1	swelling					809:816	film swelling	804:816	film swelling	804:816	The film swelling and drug release decreased with the CS ratio.
32718644	4	41	theme	bond	412:415	arg1	formation					417:425	hydrogen bond formation	403:425	hydrogen bond formation between MGRS and CS	403:445	ATR-FTIR confirmed hydrogen bond formation between MGRS and CS.
32718644	5	42	theme	films	499:503	arg1	state					475:479	an amorphous state	462:479	an amorphous state of all fabricated films	462:503	XRD indicated an amorphous state of all fabricated films.
32718644	6	43	theme	uniform	510:516	arg1	thickness					533:541	The uniform and comparable thickness	506:541	The uniform and comparable thickness	506:541	The uniform and comparable thickness, weight, and drug contents of all fabricated films were obtained.
32718644	2	44	dep	2:1	258:260	arg1	1:1					263:265	1:1	263:265	1:1	263:265	Effect of CS ratios (2:1, 1:1, 1:2 MGRS:CS) on the film properties was investigated.
32718644	2	44	dep	2:1	258:260	arg1	MGRS					272:275	1:2 MGRS	268:275	1:2 MGRS	268:275	Effect of CS ratios (2:1, 1:1, 1:2 MGRS:CS) on the film properties was investigated.
32718644	6	45	theme	comparable	522:531	arg1	thickness					533:541	The uniform and comparable thickness	506:541	The uniform and comparable thickness	506:541	The uniform and comparable thickness, weight, and drug contents of all fabricated films were obtained.
32718644	11	46	theme	buccal	1074:1079	arg1	delivery					1081:1088	buccal delivery	1074:1088	buccal delivery of hydrophilic drug	1074:1108	In conclusion, the MGRS:CS composite could be useful for buccal delivery of hydrophilic drug.
32718644	10	47	theme	CS	938:939	arg1	effect					928:933	the enhancement effect	912:933	the enhancement effect	912:933	Drug permeation across porcine mucosa indicated the enhancement effect of CS, whereby the permeation flux of 1:2 MGRS:CS composite increased by 3 folds.
32718644	2	48	theme	ratios	250:255	arg1	Effect					237:242	Effect	237:242	Effect of CS ratios (2:1, 1:1, 1:2 MGRS:CS) on the film properties	237:302	Effect of CS ratios (2:1, 1:1, 1:2 MGRS:CS) on the film properties was investigated.
32718644	1	49	theme	ball-milling	137:148	arg1	MGRS					182:185	MGRS	182:185	MGRS	182:185	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	1	49	theme	ball-milling	137:148	arg1	starch					174:179	ball-milling modified glutinous rice starch	137:179	ball-milling modified glutinous rice starch (MGRS)	137:186	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	8	50	theme	tensile	695:701	arg1	strength					703:710	tensile strength	695:710	tensile strength	695:710	The increase in tensile strength and decreases in elongation and folding endurance were observed with 1:2 MGRS:CS films.
32718644	8	51	from	decreases	716:724	arg1	strength					703:710	tensile strength	695:710	tensile strength	695:710	The increase in tensile strength and decreases in elongation and folding endurance were observed with 1:2 MGRS:CS films.
32718644	8	51	from	decreases	716:724	arg1	folding					744:750	folding	744:750	folding	744:750	The increase in tensile strength and decreases in elongation and folding endurance were observed with 1:2 MGRS:CS films.
32718644	8	51	from	decreases	716:724	arg1	elongation					729:738	elongation	729:738	elongation	729:738	The increase in tensile strength and decreases in elongation and folding endurance were observed with 1:2 MGRS:CS films.
32718644	10	52	theme	permeation	954:963	arg1	flux					965:968	the permeation flux	950:968	the permeation flux of 1:2 MGRS:CS composite	950:993	Drug permeation across porcine mucosa indicated the enhancement effect of CS, whereby the permeation flux of 1:2 MGRS:CS composite increased by 3 folds.
32718644	2	53	theme	CS	247:248	arg1	ratios					250:255	CS ratios	247:255	CS ratios (2:1, 1:1, 1:2 MGRS:CS)	247:279	Effect of CS ratios (2:1, 1:1, 1:2 MGRS:CS) on the film properties was investigated.
32718644	5	54	theme	amorphous	465:473	arg1	state					475:479	an amorphous state	462:479	an amorphous state of all fabricated films	462:503	XRD indicated an amorphous state of all fabricated films.
32718644	1	55	theme	modified	150:157	arg1	MGRS					182:185	MGRS	182:185	MGRS	182:185	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	1	55	theme	modified	150:157	arg1	starch					174:179	ball-milling modified glutinous rice starch	137:179	ball-milling modified glutinous rice starch (MGRS)	137:186	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	6	56	theme	films	588:592	arg1	weight					544:549	weight	544:549	weight	544:549	The uniform and comparable thickness, weight, and drug contents of all fabricated films were obtained.
32718644	6	56	theme	films	588:592	arg1	thickness					533:541	The uniform and comparable thickness	506:541	The uniform and comparable thickness	506:541	The uniform and comparable thickness, weight, and drug contents of all fabricated films were obtained.
32718644	6	56	theme	films	588:592	arg1	contents					561:568	drug contents	556:568	drug contents	556:568	The uniform and comparable thickness, weight, and drug contents of all fabricated films were obtained.
32718644	1	57	dep	fabrication	101:111	arg1	demonstrated					223:234	demonstrated	223:234	were demonstrated	218:234	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	1	57	dep	fabrication	101:111	arg1	The					97:99	The	97:99	The	97:99	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	6	58	theme	fabricated	577:586	arg1	films					588:592	all fabricated films	573:592	all fabricated films	573:592	The uniform and comparable thickness, weight, and drug contents of all fabricated films were obtained.
32718644	7	59	theme	films	672:676	arg1	mucoadhesiveness					647:662	the mucoadhesiveness	643:662	the mucoadhesiveness of MGRS films	643:676	The presence of CS did not affect the mucoadhesiveness of MGRS films.
32718644	1	60	theme	rice	169:172	arg1	MGRS					182:185	MGRS	182:185	MGRS	182:185	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	1	60	theme	rice	169:172	arg1	starch					174:179	ball-milling modified glutinous rice starch	137:179	ball-milling modified glutinous rice starch (MGRS)	137:186	The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated.
32718644	8	61	theme	1:2	781:783	arg1	MGRS					785:788	1:2 MGRS	781:788	1:2 MGRS	781:788	The increase in tensile strength and decreases in elongation and folding endurance were observed with 1:2 MGRS:CS films.
32179112	4	0	theme	branched	951:958	arg1	chains					974:979	more linked, branched, and long SSP chains	938:979	more linked, branched, and long SSP chains	938:979	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	3	1	theme	methylation	692:702	arg1	results					681:687	the results	677:687	the results of methylation and monosaccharide composition	677:733	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	4	2	theme	force	864:868	arg1	microscopy					870:879	Atomic force microscopy	857:879	Atomic force microscopy images	857:886	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	0	3	theme	pectin	73:78	arg1	evolution					35:43	the evolution	31:43	the evolution of sodium carbonate-soluble pectin during sweet cherry softening under non-isothermal conditions	31:140	Effect of chitosan coatings on the evolution of sodium carbonate-soluble pectin during sweet cherry softening under non-isothermal conditions.
32179112	5	4	theme	chitosan	1071:1078	arg1	feasible					1091:1098	feasible	1091:1098	feasible	1091:1098	These results indicated that a chitosan coating is feasible to preserve postharvest fruit under non-isothermal conditions.
32179112	5	4	theme	chitosan	1071:1078	arg1	coating					1080:1086	a chitosan coating	1069:1086	a chitosan coating	1069:1086	These results indicated that a chitosan coating is feasible to preserve postharvest fruit under non-isothermal conditions.
32179112	2	5	dep	content	435:441	arg1	%					447:447	6.6%	444:447	6.6% greater than the control group	444:478	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	1	6	theme	chitosan	168:175	arg1	coating					177:183	chitosan coating	168:183	chitosan coating (2%)	168:188	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	1	6	theme	chitosan	168:175	arg1	%					187:187	2%	186:187	2%	186:187	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	3	7	theme	side	830:833	arg1	chain					835:839	side chain	830:839	side chain	830:839	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	1	8	theme	SSP	244:246	arg1	evolution					249:257	sodium carbonate-soluble pectin (SSP) evolution	211:257	sodium carbonate-soluble pectin (SSP) evolution	211:257	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	0	9	theme	cherry	93:98	arg1	softening					100:108	sweet cherry softening	87:108	sweet cherry softening under non-isothermal conditions	87:140	Effect of chitosan coatings on the evolution of sodium carbonate-soluble pectin during sweet cherry softening under non-isothermal conditions.
32179112	0	10	from	Effect	0:5	arg1	evolution					35:43	the evolution	31:43	the evolution of sodium carbonate-soluble pectin during sweet cherry softening under non-isothermal conditions	31:140	Effect of chitosan coatings on the evolution of sodium carbonate-soluble pectin during sweet cherry softening under non-isothermal conditions.
32179112	3	11	dep	RG-I	816:819	arg1	sugars					849:854	neutral sugars	841:854	neutral sugars	841:854	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	3	12	theme	chain	835:839	arg1	demethylation					779:791	demethylation	779:791	demethylation of SSP	779:798	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	3	12	theme	chain	835:839	arg1	loss					808:811	the loss	804:811	the loss of RG-I main and side chain neutral sugars	804:854	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	3	13	theme	SSP	796:798	arg1	demethylation					779:791	demethylation	779:791	demethylation of SSP	779:798	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	3	13	theme	SSP	796:798	arg1	loss					808:811	the loss	804:811	the loss of RG-I main and side chain neutral sugars	804:854	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	0	14	theme	sweet	87:91	arg1	softening					100:108	sweet cherry softening	87:108	sweet cherry softening under non-isothermal conditions	87:140	Effect of chitosan coatings on the evolution of sodium carbonate-soluble pectin during sweet cherry softening under non-isothermal conditions.
32179112	2	15	theme	methylesterase	593:606	arg1	activity					608:615	pectin methylesterase activity	586:615	pectin methylesterase activity of sweet	586:624	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	5	16	theme	postharvest	1112:1122	arg1	fruit					1124:1128	postharvest fruit	1112:1128	postharvest fruit	1112:1128	These results indicated that a chitosan coating is feasible to preserve postharvest fruit under non-isothermal conditions.
32179112	1	17	from	effect	158:163	arg1	softening					197:205	softening	197:205	softening	197:205	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	1	17	from	effect	158:163	arg1	evolution					249:257	sodium carbonate-soluble pectin (SSP) evolution	211:257	sodium carbonate-soluble pectin (SSP) evolution	211:257	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	1	18	theme	coating	177:183	arg1	effect					158:163	The inhibiting effect	143:163	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage	143:305	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	2	19	theme	temperature	641:651	arg1	variation					653:661	temperature variation	641:661	temperature variation	641:661	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	2	20	dep	softening	367:375	arg1	reduced					486:492	reduced	486:492	reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes	486:566	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	2	20	dep	softening	367:375	arg1	maintained					416:425	maintained	416:425	maintained the SSP content (6.6% greater than the control group)	416:479	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	2	20	dep	softening	367:375	arg1	%					381:381	6.4%	378:381	6.4% greater than the control group	378:412	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	2	21	theme	greater	383:389	arg1	%					381:381	6.4%	378:381	6.4% greater than the control group	378:412	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	2	22	theme	SSP	431:433	arg1	content					435:441	the SSP content	427:441	the SSP content (6.6% greater than the control group)	427:479	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	2	23	theme	greater	449:455	arg1	%					447:447	6.6%	444:447	6.6% greater than the control group	444:478	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	2	24	theme	control	466:472	arg1	group					474:478	the control group	462:478	the control group	462:478	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	4	25	theme	sweet	913:917	arg1	cherries					919:926	the coated sweet cherries	902:926	the coated sweet cherries	902:926	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	3	26	theme	monosaccharide	708:721	arg1	composition					723:733	monosaccharide composition	708:733	monosaccharide composition	708:733	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	2	27	theme	genes	562:566	arg1	expression					535:544	the expression	531:544	the expression of the paPME1-5 genes	531:566	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	0	28	theme	coatings	19:26	arg1	Effect					0:5	Effect	0:5	Effect of chitosan coatings on the evolution of sodium carbonate-soluble pectin during sweet cherry softening under non-isothermal conditions.	0:141	Effect of chitosan coatings on the evolution of sodium carbonate-soluble pectin during sweet cherry softening under non-isothermal conditions.
32179112	1	29	theme	sweet	262:266	arg1	cherries					268:275	sweet cherries	262:275	sweet cherries	262:275	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	2	30	theme	pectin	586:591	arg1	activity					608:615	pectin methylesterase activity	586:615	pectin methylesterase activity of sweet	586:624	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	0	31	theme	chitosan	10:17	arg1	coatings					19:26	chitosan coatings	10:26	chitosan coatings	10:26	Effect of chitosan coatings on the evolution of sodium carbonate-soluble pectin during sweet cherry softening under non-isothermal conditions.
32179112	1	32	theme	cherries	268:275	arg1	evolution					249:257	sodium carbonate-soluble pectin (SSP) evolution	211:257	sodium carbonate-soluble pectin (SSP) evolution	211:257	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	1	32	theme	cherries	268:275	arg1	softening					197:205	softening	197:205	softening	197:205	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	0	33	theme	non-isothermal	116:129	arg1	conditions					131:140	non-isothermal conditions	116:140	non-isothermal conditions	116:140	Effect of chitosan coatings on the evolution of sodium carbonate-soluble pectin during sweet cherry softening under non-isothermal conditions.
32179112	4	34	theme	linked	943:948	arg1	chains					974:979	more linked, branched, and long SSP chains	938:979	more linked, branched, and long SSP chains	938:979	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	5	35	theme	non-isothermal	1136:1149	arg1	conditions					1151:1160	non-isothermal conditions	1136:1160	non-isothermal conditions	1136:1160	These results indicated that a chitosan coating is feasible to preserve postharvest fruit under non-isothermal conditions.
32179112	4	36	link	linked	943:948	arg1	chains					974:979	more linked, branched, and long SSP chains	938:979	more linked, branched, and long SSP chains	938:979	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	4	37	theme	pectin	1013:1018	arg1	>140 nm					1030:1036	>140 nm	1030:1036	>140 nm	1030:1036	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	4	37	theme	pectin	1013:1018	arg1	backbone					1020:1027	the pectin backbone	1009:1027	the pectin backbone (>140 nm)	1009:1037	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	2	38	theme	control	400:406	arg1	group					408:412	the control group	396:412	the control group	396:412	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	1	39	theme	non-isothermal	284:297	arg1	storage					299:305	non-isothermal storage	284:305	non-isothermal storage	284:305	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	4	40	theme	SSP	970:972	arg1	chains					974:979	more linked, branched, and long SSP chains	938:979	more linked, branched, and long SSP chains	938:979	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	3	41	theme	chitosan	754:761	arg1	coating					763:769	the chitosan coating	750:769	the chitosan coating	750:769	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	4	42	theme	Atomic	857:862	arg1	microscopy					870:879	Atomic force microscopy	857:879	Atomic force microscopy images	857:886	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	3	43	theme	composition	723:733	arg1	results					681:687	the results	677:687	the results of methylation and monosaccharide composition	677:733	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	4	44	contain	contained	928:936	arg1	cherries					919:926	the coated sweet cherries	902:926	the coated sweet cherries	902:926	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	4	44	contain	contained	928:936	arg2	chains					974:979	more linked, branched, and long SSP chains	938:979	more linked, branched, and long SSP chains	938:979	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	4	45	theme	long	965:968	arg1	chains					974:979	more linked, branched, and long SSP chains	938:979	more linked, branched, and long SSP chains	938:979	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	3	46	theme	main	821:824	arg1	RG-I					816:819	RG-I main	816:824	RG-I main	816:824	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	2	47	theme	sweet	620:624	arg1	activity					608:615	pectin methylesterase activity	586:615	pectin methylesterase activity of sweet	586:624	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	4	48	theme	microscopy	870:879	arg1	images					881:886	Atomic force microscopy images	857:886	Atomic force microscopy images	857:886	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	4	49	theme	backbone	1020:1027	arg1	width					1000:1004	the width	996:1004	the width of the pectin backbone (>140 nm)	996:1037	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	2	50	theme	SSP	513:515	arg1	degradation					498:508	the degradation	494:508	the degradation of SSP	494:515	Chitosan coating significantly extend the softening (6.4% greater than the control group), maintained the SSP content (6.6% greater than the control group), and reduced the degradation of SSP by inhibiting the expression of the paPME1-5 genes, which regulating pectin methylesterase activity of sweet cherries under temperature variation.
32179112	1	51	dep	softening	197:205	arg1	the					193:195	the	193:195	the	193:195	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	4	52	theme	coated	906:911	arg1	cherries					919:926	the coated sweet cherries	902:926	the coated sweet cherries	902:926	Atomic force microscopy images revealed that the coated sweet cherries contained more linked, branched, and long SSP chains and maintained the width of the pectin backbone (>140 nm).
32179112	1	53	theme	sodium	211:216	arg1	evolution					249:257	sodium carbonate-soluble pectin (SSP) evolution	211:257	sodium carbonate-soluble pectin (SSP) evolution	211:257	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	0	54	theme	carbonate-soluble	55:71	arg1	pectin					73:78	sodium carbonate-soluble pectin	48:78	sodium carbonate-soluble pectin	48:78	Effect of chitosan coatings on the evolution of sodium carbonate-soluble pectin during sweet cherry softening under non-isothermal conditions.
32179112	1	55	theme	inhibiting	147:156	arg1	effect					158:163	The inhibiting effect	143:163	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage	143:305	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	3	56	theme	RG-I	816:819	arg1	demethylation					779:791	demethylation	779:791	demethylation of SSP	779:798	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	3	56	theme	RG-I	816:819	arg1	loss					808:811	the loss	804:811	the loss of RG-I main and side chain neutral sugars	804:854	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	1	57	theme	carbonate-soluble	218:234	arg1	evolution					249:257	sodium carbonate-soluble pectin (SSP) evolution	211:257	sodium carbonate-soluble pectin (SSP) evolution	211:257	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
32179112	0	58	theme	sodium	48:53	arg1	pectin					73:78	sodium carbonate-soluble pectin	48:78	sodium carbonate-soluble pectin	48:78	Effect of chitosan coatings on the evolution of sodium carbonate-soluble pectin during sweet cherry softening under non-isothermal conditions.
32179112	3	59	theme	neutral	841:847	arg1	sugars					849:854	neutral sugars	841:854	neutral sugars	841:854	In addition, the results of methylation and monosaccharide composition indicated that the chitosan coating reduced demethylation of SSP and the loss of RG-I main and side chain neutral sugars.
32179112	1	60	theme	pectin	236:241	arg1	evolution					249:257	sodium carbonate-soluble pectin (SSP) evolution	211:257	sodium carbonate-soluble pectin (SSP) evolution	211:257	The inhibiting effect of chitosan coating (2%) on the softening and sodium carbonate-soluble pectin (SSP) evolution of sweet cherries during non-isothermal storage was investigated.
34578474	2	0	theme	human	369:373	arg1	proteins					375:382	human proteins	369:382	human proteins	369:382	For comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins, time-consuming multi-step enrichment of glycopeptides is required.
34578474	7	1	gly	glycopeptides	1453:1465	arg2	glycopeptides					1453:1465	sialylated glycopeptides	1442:1465	sialylated glycopeptides	1442:1465	The glycoproteomics atlas also revealed the differential pattern of sialylated glycopeptides between HBV and HCC groups.
34578474	6	2	with	patients	1160:1167	arg1	virus					1186:1190	hepatitis B virus	1174:1190	hepatitis B virus (HBV, n = 3)	1174:1203	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	6	2	with	patients	1160:1167	arg1	carcinoma					1224:1232	hepatocellular carcinoma	1209:1232	hepatocellular carcinoma (HCC, n = 3)	1209:1245	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	6	3	theme	=	1200:1200	arg1	n					1198:1198	n	1198:1198	n = 3	1198:1202	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	6	3	theme	=	1200:1200	arg1	HBV					1193:1195	HBV	1193:1195	HBV	1193:1195	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	4	4	theme	@	676:676	arg1	MNPs					677:680	ZIC-cHILIC@MNPs	666:680	ZIC-cHILIC@MNPs	666:680	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	7	5	theme	HCC	1483:1485	arg1	groups					1487:1492	HBV and HCC groups	1475:1492	groups	1487:1492	The glycoproteomics atlas also revealed the differential pattern of sialylated glycopeptides between HBV and HCC groups.
34578474	2	6	theme	comprehensive	278:290	arg1	characterization					292:307	comprehensive characterization	278:307	comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins	278:382	For comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins, time-consuming multi-step enrichment of glycopeptides is required.
34578474	7	7	theme	HBV	1475:1477	arg1	groups					1487:1492	HBV and HCC groups	1475:1492	groups	1487:1492	The glycoproteomics atlas also revealed the differential pattern of sialylated glycopeptides between HBV and HCC groups.
34578474	2	8	theme	complexity	337:346	arg1	characterization					292:307	comprehensive characterization	278:307	comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins	278:382	For comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins, time-consuming multi-step enrichment of glycopeptides is required.
34578474	1	9	theme	significant	194:204	arg1	roles					206:210	significant roles	194:210	significant roles	194:210	Due to their unique glycan composition and linkage, protein glycosylation plays significant roles in cellular function and is associated with various diseases.
34578474	6	10	theme	B	1184:1184	arg1	virus					1186:1190	hepatitis B virus	1174:1190	hepatitis B virus (HBV, n = 3)	1174:1203	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	6	11	theme	large-scale	1303:1313	arg1	identification					1315:1328	the large-scale identification	1299:1328	the large-scale identification of under-explored sialylated glycopeptides	1299:1371	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	3	12	theme	glycopeptides	631:643	arg1	enrichment					617:626	large-scale enrichment	605:626	large-scale enrichment of glycopeptides	605:643	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	5	13	theme	<1	897:898	arg1	serum					903:907	<1 μL serum	897:907	<1 μL serum	897:907	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	5	13	theme	<1	897:898	arg1	sensitivity					884:894	high sensitivity	879:894	high sensitivity (<1 μL serum)	879:908	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	7	14	theme	glycoproteomics	1378:1392	arg1	atlas					1394:1398	The glycoproteomics atlas	1374:1398	The glycoproteomics atlas	1374:1398	The glycoproteomics atlas also revealed the differential pattern of sialylated glycopeptides between HBV and HCC groups.
34578474	6	15	dep	=	1200:1200	arg1	3					1202:1202	3	1202:1202	3	1202:1202	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	5	16	theme	affinity	1069:1076	arg1	nanoprobe					1078:1086	the affinity nanoprobe	1065:1086	the affinity nanoprobe	1065:1086	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	6	17	theme	hepatocellular	1209:1222	arg1	carcinoma					1224:1232	hepatocellular carcinoma	1209:1232	hepatocellular carcinoma (HCC, n = 3)	1209:1245	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	3	18	gly	glycopeptides	631:643	arg2	glycopeptides					631:643	glycopeptides	631:643	glycopeptides	631:643	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	4	19	gly	sialylated	778:787	arg1	glycopeptide					789:800	sialylated glycopeptide	778:800	sialylated glycopeptide (90%) from biofluid specimens	778:830	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	4	19	gly	sialylated	778:787	arg1	%					805:805	90%	803:805	90%	803:805	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	7	20	theme	sialylated	1442:1451	arg1	glycopeptides					1453:1465	sialylated glycopeptides	1442:1465	sialylated glycopeptides	1442:1465	The glycoproteomics atlas also revealed the differential pattern of sialylated glycopeptides between HBV and HCC groups.
34578474	1	21	theme	glycan	134:139	arg1	composition					141:151	their unique glycan composition	121:151	their unique glycan composition	121:151	Due to their unique glycan composition and linkage, protein glycosylation plays significant roles in cellular function and is associated with various diseases.
34578474	5	22	from	nanoscale	1091:1099	arg1	performance					1050:1060	high performance	1045:1060	high performance of the affinity nanoprobe at nanoscale	1045:1099	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	5	22	from	nanoscale	1091:1099	arg1	nanoparticles					1011:1023	magnetic nanoparticles	1002:1023	magnetic nanoparticles	1002:1023	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	5	22	from	nanoscale	1091:1099	arg1	reaction					1031:1038	fast reaction	1026:1038	fast reaction	1026:1038	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	4	23	contain	possess	682:688	arg2	affinity					700:707	excellent affinity	690:707	excellent affinity	690:707	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	4	23	contain	possess	682:688	arg1	MNPs					677:680	ZIC-cHILIC@MNPs	666:680	ZIC-cHILIC@MNPs	666:680	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	8	24	theme	@	1509:1509	arg1	tool					1534:1537	a generic tool	1524:1537	a generic tool for advancing the glycoproteome analysis	1524:1578	The ZIC-cHILIC@MNPs could be a generic tool for advancing the glycoproteome analysis, and contribute to the screening of glycoprotein biomarkers.
34578474	8	24	theme	@	1509:1509	arg1	MNPs					1510:1513	The ZIC-cHILIC@MNPs	1495:1513	The ZIC-cHILIC@MNPs	1495:1513	The ZIC-cHILIC@MNPs could be a generic tool for advancing the glycoproteome analysis, and contribute to the screening of glycoprotein biomarkers.
34578474	4	25	theme	sialylated	778:787	arg1	glycopeptide					789:800	sialylated glycopeptide	778:800	sialylated glycopeptide (90%) from biofluid specimens	778:830	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	4	25	theme	sialylated	778:787	arg1	%					805:805	90%	803:805	90%	803:805	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	8	26	theme	ZIC-cHILIC	1499:1508	arg1	tool					1534:1537	a generic tool	1524:1537	a generic tool for advancing the glycoproteome analysis	1524:1578	The ZIC-cHILIC@MNPs could be a generic tool for advancing the glycoproteome analysis, and contribute to the screening of glycoprotein biomarkers.
34578474	8	26	theme	ZIC-cHILIC	1499:1508	arg1	MNPs					1510:1513	The ZIC-cHILIC@MNPs	1495:1513	The ZIC-cHILIC@MNPs	1495:1513	The ZIC-cHILIC@MNPs could be a generic tool for advancing the glycoproteome analysis, and contribute to the screening of glycoprotein biomarkers.
34578474	5	27	theme	patient	946:952	arg1	serum					954:958	patient serum	946:958	patient serum	946:958	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	0	28	theme	µL	104:105	arg1	Serum					107:111	<1 µL Serum	101:111	<1 µL Serum	101:111	ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.
34578474	7	29	theme	glycopeptides	1453:1465	arg1	pattern					1431:1437	the differential pattern	1414:1437	the differential pattern of sialylated glycopeptides between HBV and HCC groups	1414:1492	The glycoproteomics atlas also revealed the differential pattern of sialylated glycopeptides between HBV and HCC groups.
34578474	5	30	theme	magnetic	1002:1009	arg1	nanoparticles					1011:1023	magnetic nanoparticles	1002:1023	magnetic nanoparticles	1002:1023	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	2	31	theme	glycopeptides	425:437	arg1	enrichment					411:420	time-consuming multi-step enrichment	385:420	time-consuming multi-step enrichment of glycopeptides	385:437	For comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins, time-consuming multi-step enrichment of glycopeptides is required.
34578474	4	32	from	specimens	822:830	arg1	glycopeptide					789:800	sialylated glycopeptide	778:800	sialylated glycopeptide (90%) from biofluid specimens	778:830	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	4	32	from	specimens	822:830	arg1	%					805:805	90%	803:805	90%	803:805	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	0	33	theme	ZIC-cHILIC	0:9	arg1	Nanoparticle					35:46	ZIC-cHILIC Functionalized Magnetic Nanoparticle	0:46	ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.	0:112	ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.
34578474	5	34	theme	high	1045:1048	arg1	performance					1050:1060	high performance	1045:1060	high performance of the affinity nanoprobe at nanoscale	1045:1099	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	0	35	theme	Magnetic	26:33	arg1	Nanoparticle					35:46	ZIC-cHILIC Functionalized Magnetic Nanoparticle	0:46	ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.	0:112	ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.
34578474	8	36	theme	glycoproteome	1557:1569	arg1	analysis					1571:1578	the glycoproteome analysis	1553:1578	the glycoproteome analysis	1553:1578	The ZIC-cHILIC@MNPs could be a generic tool for advancing the glycoproteome analysis, and contribute to the screening of glycoprotein biomarkers.
34578474	3	37	theme	magnetic	519:526	arg1	nanoparticles					528:540	zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles	467:540	zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides	467:643	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	3	37	theme	magnetic	519:526	arg1	MNPs					554:557	ZIC-cHILIC@MNPs	543:557	ZIC-cHILIC@MNPs	543:557	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	6	38	gly	glycopeptides	1359:1371	arg2	glycopeptides					1359:1371	under-explored sialylated glycopeptides	1333:1371	under-explored sialylated glycopeptides	1333:1371	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	0	39	theme	Glycopeptide	72:83	arg1	Enrichment					85:94	Rapid and Sensitive Glycopeptide Enrichment	52:94	Rapid and Sensitive Glycopeptide Enrichment	52:94	ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.
34578474	8	40	gly	glycoprotein	1616:1627	arg1	glycoprotein					1616:1627	glycoprotein biomarkers	1616:1638	glycoprotein biomarkers	1616:1638	The ZIC-cHILIC@MNPs could be a generic tool for advancing the glycoproteome analysis, and contribute to the screening of glycoprotein biomarkers.
34578474	6	41	theme	patients	1160:1167	arg1	profiles					1148:1155	personalized profiles	1135:1155	personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3)	1135:1245	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	3	42	theme	@	553:553	arg1	nanoparticles					528:540	zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles	467:540	zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides	467:643	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	3	42	theme	@	553:553	arg1	MNPs					554:557	ZIC-cHILIC@MNPs	543:557	ZIC-cHILIC@MNPs	543:557	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	3	43	theme	efficient	572:580	arg1	nanoprobe					591:599	a highly efficient affinity nanoprobe	563:599	a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides	563:643	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	4	44	theme	excellent	690:698	arg1	affinity					700:707	excellent affinity	690:707	excellent affinity	690:707	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	2	45	theme	proteins	375:382	arg1	%					364:364	>50%	361:364	>50% of human proteins	361:382	For comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins, time-consuming multi-step enrichment of glycopeptides is required.
34578474	2	45	theme	proteins	375:382	arg1	proteins					375:382	human proteins	369:382	human proteins	369:382	For comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins, time-consuming multi-step enrichment of glycopeptides is required.
34578474	1	46	theme	various	256:262	arg1	diseases					264:271	various diseases	256:271	various diseases	256:271	Due to their unique glycan composition and linkage, protein glycosylation plays significant roles in cellular function and is associated with various diseases.
34578474	8	47	theme	biomarkers	1629:1638	arg1	screening					1603:1611	the screening	1599:1611	the screening of glycoprotein biomarkers	1599:1638	The ZIC-cHILIC@MNPs could be a generic tool for advancing the glycoproteome analysis, and contribute to the screening of glycoprotein biomarkers.
34578474	4	48	gly	glycopeptide	738:749	arg2	glycopeptide					738:749	glycopeptide enrichment	738:760	glycopeptide enrichment	738:760	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	3	49	theme	large-scale	605:615	arg1	enrichment					617:626	large-scale enrichment	605:626	large-scale enrichment of glycopeptides	605:643	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	7	50	gly	sialylated	1442:1451	arg1	glycopeptides					1453:1465	sialylated glycopeptides	1442:1465	sialylated glycopeptides	1442:1465	The glycoproteomics atlas also revealed the differential pattern of sialylated glycopeptides between HBV and HCC groups.
34578474	6	51	gly	glycopeptides	1269:1281	arg2	glycopeptides					1269:1281	>3000 glycopeptides	1263:1281	>3000 glycopeptides	1263:1281	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	4	52	theme	ZIC-cHILIC	666:675	arg1	MNPs					677:680	ZIC-cHILIC@MNPs	666:680	ZIC-cHILIC@MNPs	666:680	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	1	53	theme	protein	166:172	arg1	glycosylation					174:186	protein glycosylation	166:186	protein glycosylation	166:186	Due to their unique glycan composition and linkage, protein glycosylation plays significant roles in cellular function and is associated with various diseases.
34578474	6	54	theme	=	1242:1242	arg1	n					1240:1240	n	1240:1240	n = 3	1240:1244	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	6	54	theme	=	1242:1242	arg1	HCC					1235:1237	HCC	1235:1237	HCC	1235:1237	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	7	55	theme	differential	1418:1429	arg1	pattern					1431:1437	the differential pattern	1414:1437	the differential pattern of sialylated glycopeptides between HBV and HCC groups	1414:1492	The glycoproteomics atlas also revealed the differential pattern of sialylated glycopeptides between HBV and HCC groups.
34578474	6	56	dep	virus	1186:1190	arg1	n					1198:1198	n	1198:1198	n = 3	1198:1202	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	6	56	dep	virus	1186:1190	arg1	HBV					1193:1195	HBV	1193:1195	HBV	1193:1195	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	4	57	gly	glycopeptide	789:800	arg2	%					805:805	90%	803:805	90%	803:805	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	4	57	gly	glycopeptide	789:800	arg1	specimens					822:830	biofluid specimens	813:830	biofluid specimens	813:830	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	4	57	gly	glycopeptide	789:800	arg2	glycopeptide					789:800	sialylated glycopeptide	778:800	sialylated glycopeptide (90%) from biofluid specimens	778:830	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	2	58	theme	structural	326:335	arg1	complexity					337:346	their extreme structural complexity	312:346	their extreme structural complexity occurring in >50% of human proteins	312:382	For comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins, time-consuming multi-step enrichment of glycopeptides is required.
34578474	2	59	theme	time-consuming	385:398	arg1	enrichment					411:420	time-consuming multi-step enrichment	385:420	time-consuming multi-step enrichment of glycopeptides	385:437	For comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins, time-consuming multi-step enrichment of glycopeptides is required.
34578474	6	60	theme	hepatitis	1174:1182	arg1	virus					1186:1190	hepatitis B virus	1174:1190	hepatitis B virus (HBV, n = 3)	1174:1203	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	4	61	theme	glycopeptide	738:749	arg1	enrichment					751:760	glycopeptide enrichment	738:760	glycopeptide enrichment	738:760	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	5	62	theme	μL	900:901	arg1	serum					903:907	<1 μL serum	897:907	<1 μL serum	897:907	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	5	62	theme	μL	900:901	arg1	sensitivity					884:894	high sensitivity	879:894	high sensitivity (<1 μL serum)	879:908	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	4	63	theme	80-91	715:719	arg1	%					720:720	%	720:720	%	720:720	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	6	64	theme	glycopeptides	1269:1281	arg1	depth					1254:1258	the depth	1250:1258	the depth of >3000 glycopeptides	1250:1281	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	5	65	theme	nanoprobe	1078:1086	arg1	performance					1050:1060	high performance	1045:1060	high performance of the affinity nanoprobe at nanoscale	1045:1099	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	5	65	theme	nanoprobe	1078:1086	arg1	nanoparticles					1011:1023	magnetic nanoparticles	1002:1023	magnetic nanoparticles	1002:1023	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	5	65	theme	nanoprobe	1078:1086	arg1	reaction					1031:1038	fast reaction	1026:1038	fast reaction	1026:1038	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	1	66	theme	unique	127:132	arg1	composition					141:151	their unique glycan composition	121:151	their unique glycan composition	121:151	Due to their unique glycan composition and linkage, protein glycosylation plays significant roles in cellular function and is associated with various diseases.
34578474	5	67	theme	whole	918:922	arg1	process					935:941	the whole enrichment process	914:941	the whole enrichment process in patient serum	914:958	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	0	68	from	Serum	107:111	arg1	Nanoparticle					35:46	ZIC-cHILIC Functionalized Magnetic Nanoparticle	0:46	ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.	0:112	ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.
34578474	5	69	theme	enrichment	924:933	arg1	process					935:941	the whole enrichment process	914:941	the whole enrichment process in patient serum	914:958	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	6	70	dep	carcinoma	1224:1232	arg1	n					1240:1240	n	1240:1240	n = 3	1240:1244	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	6	70	dep	carcinoma	1224:1232	arg1	HCC					1235:1237	HCC	1235:1237	HCC	1235:1237	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	6	71	theme	sialylated	1348:1357	arg1	glycopeptides					1359:1371	under-explored sialylated glycopeptides	1333:1371	under-explored sialylated glycopeptides	1333:1371	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	0	72	theme	<1	101:102	arg1	Serum					107:111	<1 µL Serum	101:111	<1 µL Serum	101:111	ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.
34578474	6	73	theme	glycopeptides	1359:1371	arg1	identification					1315:1328	the large-scale identification	1299:1328	the large-scale identification of under-explored sialylated glycopeptides	1299:1371	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	2	74	theme	extreme	318:324	arg1	complexity					337:346	their extreme structural complexity	312:346	their extreme structural complexity occurring in >50% of human proteins	312:382	For comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins, time-consuming multi-step enrichment of glycopeptides is required.
34578474	8	75	theme	generic	1526:1532	arg1	tool					1534:1537	a generic tool	1524:1537	a generic tool for advancing the glycoproteome analysis	1524:1578	The ZIC-cHILIC@MNPs could be a generic tool for advancing the glycoproteome analysis, and contribute to the screening of glycoprotein biomarkers.
34578474	8	75	theme	generic	1526:1532	arg1	MNPs					1510:1513	The ZIC-cHILIC@MNPs	1495:1513	The ZIC-cHILIC@MNPs	1495:1513	The ZIC-cHILIC@MNPs could be a generic tool for advancing the glycoproteome analysis, and contribute to the screening of glycoprotein biomarkers.
34578474	6	76	theme	under-explored	1333:1346	arg1	glycopeptides					1359:1371	under-explored sialylated glycopeptides	1333:1371	under-explored sialylated glycopeptides	1333:1371	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	5	77	from	process	935:941	arg1	serum					954:958	patient serum	946:958	patient serum	946:958	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	2	78	gly	glycopeptides	425:437	arg2	glycopeptides					425:437	glycopeptides	425:437	glycopeptides	425:437	For comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins, time-consuming multi-step enrichment of glycopeptides is required.
34578474	1	79	theme	cellular	215:222	arg1	function					224:231	cellular function	215:231	cellular function	215:231	Due to their unique glycan composition and linkage, protein glycosylation plays significant roles in cellular function and is associated with various diseases.
34578474	3	80	theme	n-dodecylphosphocholine-functionalized	480:517	arg1	nanoparticles					528:540	zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles	467:540	zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides	467:643	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	3	80	theme	n-dodecylphosphocholine-functionalized	480:517	arg1	MNPs					554:557	ZIC-cHILIC@MNPs	543:557	ZIC-cHILIC@MNPs	543:557	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	0	81	theme	Functionalized	11:24	arg1	Nanoparticle					35:46	ZIC-cHILIC Functionalized Magnetic Nanoparticle	0:46	ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.	0:112	ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.
34578474	2	82	theme	multi-step	400:409	arg1	enrichment					411:420	time-consuming multi-step enrichment	385:420	time-consuming multi-step enrichment of glycopeptides	385:437	For comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins, time-consuming multi-step enrichment of glycopeptides is required.
34578474	5	83	theme	high	879:882	arg1	serum					903:907	<1 μL serum	897:907	<1 μL serum	897:907	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	5	83	theme	high	879:882	arg1	sensitivity					884:894	high sensitivity	879:894	high sensitivity (<1 μL serum)	879:908	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	5	84	theme	rapid	979:983	arg1	separation					985:994	the rapid separation	975:994	the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale	975:1099	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	4	85	theme	biofluid	813:820	arg1	specimens					822:830	biofluid specimens	813:830	biofluid specimens	813:830	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	3	86	theme	ZIC-cHILIC	543:552	arg1	nanoparticles					528:540	zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles	467:540	zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides	467:643	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	3	86	theme	ZIC-cHILIC	543:552	arg1	MNPs					554:557	ZIC-cHILIC@MNPs	543:557	ZIC-cHILIC@MNPs	543:557	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	0	87	theme	Rapid	52:56	arg1	Enrichment					85:94	Rapid and Sensitive Glycopeptide Enrichment	52:94	Rapid and Sensitive Glycopeptide Enrichment	52:94	ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.
34578474	4	88	theme	%	720:720	arg1	specificity					722:732	80-91% specificity	715:732	80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens	715:830	We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80-91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens.
34578474	6	89	gly	sialylated	1348:1357	arg1	glycopeptides					1359:1371	under-explored sialylated glycopeptides	1333:1371	under-explored sialylated glycopeptides	1333:1371	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	3	90	theme	zwitterionic	467:478	arg1	nanoparticles					528:540	zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles	467:540	zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides	467:643	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	3	90	theme	zwitterionic	467:478	arg1	MNPs					554:557	ZIC-cHILIC@MNPs	543:557	ZIC-cHILIC@MNPs	543:557	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
34578474	0	91	theme	Sensitive	62:70	arg1	Enrichment					85:94	Rapid and Sensitive Glycopeptide Enrichment	52:94	Rapid and Sensitive Glycopeptide Enrichment	52:94	ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.
34578474	5	92	theme	fast	1026:1029	arg1	reaction					1031:1038	fast reaction	1026:1038	fast reaction	1026:1038	This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale.
34578474	6	93	dep	=	1242:1242	arg1	3					1244:1244	3	1244:1244	3	1244:1244	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	6	94	theme	personalized	1135:1146	arg1	profiles					1148:1155	personalized profiles	1135:1155	personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3)	1135:1245	Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides.
34578474	8	95	theme	glycoprotein	1616:1627	arg1	biomarkers					1629:1638	glycoprotein biomarkers	1616:1638	glycoprotein biomarkers	1616:1638	The ZIC-cHILIC@MNPs could be a generic tool for advancing the glycoproteome analysis, and contribute to the screening of glycoprotein biomarkers.
34578474	3	96	theme	affinity	582:589	arg1	nanoprobe					591:599	a highly efficient affinity nanoprobe	563:599	a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides	563:643	Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides.
32272703	0	0	theme	ionic	92:96	arg1	Derivatives					117:127	Neutral and ionic Poly(methacrylate) Derivatives	80:127	Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations	80:183	Understanding the Structure and Dynamics of Nanocellulose-Based Composites with Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations.
32272703	5	1	dep	structure	1158:1166	arg1	the					1154:1156	the	1154:1156	the	1154:1156	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	0	2	with	Dynamics	32:39	arg1	Derivatives					117:127	Neutral and ionic Poly(methacrylate) Derivatives	80:127	Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations	80:183	Understanding the Structure and Dynamics of Nanocellulose-Based Composites with Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations.
32272703	3	3	theme	ionic	875:879	arg1	derivatives					900:910	the ionic poly(methacrylate) derivatives	871:910	the ionic poly(methacrylate) derivatives	871:910	The differences between the spectra of the nanocomposites and the pure precursors indicate that interactions between the components are stronger for the ionic poly(methacrylate) derivatives than for the neutral counterpart.
32272703	2	4	theme	spectral	575:582	arg1	lines					584:588	experimental spectral lines	562:588	experimental spectral lines	562:588	A reasonable match between calculated and experimental spectral lines and their intensities was used to support the vibrational assignment of the observed bands and to validate the possible structures.
32272703	1	5	theme	scattering	412:421	arg1	spectroscopy					429:440	inelastic neutron scattering (INS) spectroscopy	394:440	inelastic neutron scattering (INS) spectroscopy	394:440	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	5	6	theme	true	1241:1244	arg1	they					1232:1235	they	1232:1235	they	1232:1235	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	5	6	theme	true	1241:1244	arg1	materials					1260:1268	true nanocomposite materials	1241:1268	true nanocomposite materials instead of simple mixtures of totally independent domains	1241:1326	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	2	7	theme	experimental	562:573	arg1	lines					584:588	experimental spectral lines	562:588	experimental spectral lines	562:588	A reasonable match between calculated and experimental spectral lines and their intensities was used to support the vibrational assignment of the observed bands and to validate the possible structures.
32272703	5	8	theme	nanocomposite	1246:1258	arg1	they					1232:1235	they	1232:1235	they	1232:1235	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	5	8	theme	nanocomposite	1246:1258	arg1	materials					1260:1268	true nanocomposite materials	1241:1268	true nanocomposite materials instead of simple mixtures of totally independent domains	1241:1326	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	0	9	theme	Poly	98:101	arg1	Derivatives					117:127	Neutral and ionic Poly(methacrylate) Derivatives	80:127	Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations	80:183	Understanding the Structure and Dynamics of Nanocellulose-Based Composites with Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations.
32272703	1	10	theme	model	505:509	arg1	systems					511:517	model systems	505:517	model systems	505:517	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	5	11	theme	nanocellulose-based	1184:1202	arg1	composites					1204:1213	nanocellulose-based composites	1184:1213	nanocellulose-based composites	1184:1213	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	4	12	theme	Displaced	946:954	arg1	anions					956:961	Displaced anions	946:961	Displaced anions	946:961	Displaced anions interact differently with cellulose chains, due to the different ability to compete with the O-H···O hydrogen bonds in cellulose.
32272703	1	13	theme	methacroylcholine	335:351	arg1	poly					330:333	poly	330:333	poly(methacroylcholine hydroxide) (PMACH)	330:370	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	13	theme	methacroylcholine	335:351	arg1	hydroxide					353:361	methacroylcholine hydroxide	335:361	methacroylcholine hydroxide	335:361	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	14	theme	systems	511:517	arg1	calculations					489:500	DFT (density functional theory) calculations	457:500	DFT (density functional theory) calculations of model systems	457:517	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	3	15	theme	pure	788:791	arg1	precursors					793:802	the pure precursors	784:802	the pure precursors	784:802	The differences between the spectra of the nanocomposites and the pure precursors indicate that interactions between the components are stronger for the ionic poly(methacrylate) derivatives than for the neutral counterpart.
32272703	2	16	theme	observed	666:673	arg1	bands					675:679	the observed bands	662:679	the observed bands	662:679	A reasonable match between calculated and experimental spectral lines and their intensities was used to support the vibrational assignment of the observed bands and to validate the possible structures.
32272703	1	17	theme	Bacterial	186:194	arg1	nanocellulose					196:208	Bacterial nanocellulose	186:208	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH)	186:370	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	17	theme	Bacterial	186:194	arg1	BC					211:212	BC	211:212	BC	211:212	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	18	theme	nanocellulose	196:208	arg1	composites					221:230	Bacterial nanocellulose (BC)-based composites	186:230	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH)	186:370	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	3	19	theme	methacrylate	886:897	arg1	derivatives					900:910	the ionic poly(methacrylate) derivatives	871:910	the ionic poly(methacrylate) derivatives	871:910	The differences between the spectra of the nanocomposites and the pure precursors indicate that interactions between the components are stronger for the ionic poly(methacrylate) derivatives than for the neutral counterpart.
32272703	2	20	theme	vibrational	636:646	arg1	assignment					648:657	the vibrational assignment	632:657	the vibrational assignment of the observed bands	632:679	A reasonable match between calculated and experimental spectral lines and their intensities was used to support the vibrational assignment of the observed bands and to validate the possible structures.
32272703	3	21	theme	neutral	925:931	arg1	counterpart					933:943	the neutral counterpart	921:943	the neutral counterpart	921:943	The differences between the spectra of the nanocomposites and the pure precursors indicate that interactions between the components are stronger for the ionic poly(methacrylate) derivatives than for the neutral counterpart.
32272703	4	22	theme	different	1018:1026	arg1	ability					1028:1034	the different ability	1014:1034	the different ability to compete with the O-H···O hydrogen bonds in cellulose	1014:1090	Displaced anions interact differently with cellulose chains, due to the different ability to compete with the O-H···O hydrogen bonds in cellulose.
32272703	2	23	theme	bands	675:679	arg1	assignment					648:657	the vibrational assignment	632:657	the vibrational assignment of the observed bands	632:679	A reasonable match between calculated and experimental spectral lines and their intensities was used to support the vibrational assignment of the observed bands and to validate the possible structures.
32272703	5	24	theme	mixtures	1288:1295	arg1	they					1232:1235	they	1232:1235	they	1232:1235	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	5	24	theme	mixtures	1288:1295	arg1	materials					1260:1268	true nanocomposite materials	1241:1268	true nanocomposite materials instead of simple mixtures of totally independent domains	1241:1326	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	0	25	theme	Neutron	145:151	arg1	Scattering					153:162	Inelastic Neutron Scattering	135:162	Inelastic Neutron Scattering	135:162	Understanding the Structure and Dynamics of Nanocellulose-Based Composites with Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations.
32272703	5	26	theme	independent	1308:1318	arg1	domains					1320:1326	totally independent domains	1300:1326	totally independent domains	1300:1326	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	1	27	theme	-based	214:219	arg1	composites					221:230	Bacterial nanocellulose (BC)-based composites	186:230	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH)	186:370	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	4	28	theme	cellulose	989:997	arg1	chains					999:1004	cellulose chains	989:1004	cellulose chains	989:1004	Displaced anions interact differently with cellulose chains, due to the different ability to compete with the O-H···O hydrogen bonds in cellulose.
32272703	1	29	theme	methacroylcholine	291:307	arg1	poly					286:289	poly	286:289	poly(methacroylcholine chloride) (PMACC)	286:325	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	29	theme	methacroylcholine	291:307	arg1	chloride					309:316	methacroylcholine chloride	291:316	methacroylcholine chloride	291:316	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	0	30	theme	Inelastic	135:143	arg1	Scattering					153:162	Inelastic Neutron Scattering	135:162	Inelastic Neutron Scattering	135:162	Understanding the Structure and Dynamics of Nanocellulose-Based Composites with Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations.
32272703	1	31	theme	DFT	457:459	arg1	calculations					489:500	DFT (density functional theory) calculations	457:500	DFT (density functional theory) calculations of model systems	457:517	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	0	32	theme	Composites	64:73	arg1	Structure					18:26	Structure	18:26	Structure	18:26	Understanding the Structure and Dynamics of Nanocellulose-Based Composites with Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations.
32272703	0	32	theme	Composites	64:73	arg1	Dynamics					32:39	Dynamics	32:39	Dynamics	32:39	Understanding the Structure and Dynamics of Nanocellulose-Based Composites with Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations.
32272703	5	33	theme	adequate	1114:1121	arg1	INS					1104:1106	the INS	1100:1106	the INS	1100:1106	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	5	33	theme	adequate	1114:1121	arg1	technique					1123:1131	an adequate technique	1111:1131	an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains	1111:1326	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	0	34	with	Structure	18:26	arg1	Derivatives					117:127	Neutral and ionic Poly(methacrylate) Derivatives	80:127	Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations	80:183	Understanding the Structure and Dynamics of Nanocellulose-Based Composites with Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations.
32272703	0	35	theme	Nanocellulose-Based	44:62	arg1	Composites					64:73	Nanocellulose-Based Composites	44:73	Nanocellulose-Based Composites	44:73	Understanding the Structure and Dynamics of Nanocellulose-Based Composites with Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations.
32272703	5	36	theme	domains	1320:1326	arg1	mixtures					1288:1295	simple mixtures	1281:1295	simple mixtures of totally independent domains	1281:1326	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	1	37	contain	containing	232:241	arg2	methacrylate					263:274	2-hydroxyethyl methacrylate	248:274	2-hydroxyethyl methacrylate	248:274	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	37	contain	containing	232:241	arg2	poly					286:289	poly	286:289	poly(methacroylcholine chloride) (PMACC)	286:325	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	37	contain	containing	232:241	arg2	PHEMA					278:282	PHEMA	278:282	PHEMA	278:282	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	37	contain	containing	232:241	arg2	PMACC					320:324	PMACC	320:324	PMACC	320:324	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	37	contain	containing	232:241	arg2	chloride					309:316	methacroylcholine chloride	291:316	methacroylcholine chloride	291:316	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	37	contain	containing	232:241	arg2	poly					330:333	poly	330:333	poly(methacroylcholine hydroxide) (PMACH)	330:370	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	37	contain	containing	232:241	arg2	PMACH					365:369	PMACH	365:369	PMACH	365:369	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	37	contain	containing	232:241	arg2	poly					243:246	poly	243:246	poly(2-hydroxyethyl methacrylate) (PHEMA)	243:283	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	37	contain	containing	232:241	arg1	composites					221:230	Bacterial nanocellulose (BC)-based composites	186:230	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH)	186:370	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	37	contain	containing	232:241	arg2	hydroxide					353:361	methacroylcholine hydroxide	335:361	methacroylcholine hydroxide	335:361	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	38	theme	density	462:468	arg1	DFT					457:459	DFT	457:459	DFT (density functional theory) calculations of model systems	457:517	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	38	theme	density	462:468	arg1	theory					481:486	density functional theory	462:486	density functional theory	462:486	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	4	39	from	bonds	1073:1077	arg1	cellulose					1082:1090	cellulose	1082:1090	cellulose	1082:1090	Displaced anions interact differently with cellulose chains, due to the different ability to compete with the O-H···O hydrogen bonds in cellulose.
32272703	4	40	theme	hydrogen	1064:1071	arg1	bonds					1073:1077	the O-H···O hydrogen bonds	1052:1077	the O-H···O hydrogen bonds in cellulose	1052:1090	Displaced anions interact differently with cellulose chains, due to the different ability to compete with the O-H···O hydrogen bonds in cellulose.
32272703	1	41	theme	functional	470:479	arg1	DFT					457:459	DFT	457:459	DFT (density functional theory) calculations of model systems	457:517	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	41	theme	functional	470:479	arg1	theory					481:486	density functional theory	462:486	density functional theory	462:486	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	4	42	theme	O-H···O	1056:1062	arg1	bonds					1073:1077	the O-H···O hydrogen bonds	1052:1077	the O-H···O hydrogen bonds in cellulose	1052:1090	Displaced anions interact differently with cellulose chains, due to the different ability to compete with the O-H···O hydrogen bonds in cellulose.
32272703	5	43	theme	composites	1204:1213	arg1	dynamics					1172:1179	dynamics	1172:1179	dynamics	1172:1179	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	5	43	theme	composites	1204:1213	arg1	structure					1158:1166	structure	1158:1166	structure	1158:1166	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	0	44	theme	DFT	168:170	arg1	Calculations					172:183	DFT Calculations	168:183	DFT Calculations	168:183	Understanding the Structure and Dynamics of Nanocellulose-Based Composites with Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations.
32272703	1	45	theme	inelastic	394:402	arg1	INS					424:426	INS	424:426	INS	424:426	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	45	theme	inelastic	394:402	arg1	scattering					412:421	inelastic neutron scattering	394:421	inelastic neutron scattering (INS) spectroscopy	394:440	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	0	46	dep	Structure	18:26	arg1	the					14:16	the	14:16	the	14:16	Understanding the Structure and Dynamics of Nanocellulose-Based Composites with Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations.
32272703	3	47	theme	poly	881:884	arg1	derivatives					900:910	the ionic poly(methacrylate) derivatives	871:910	the ionic poly(methacrylate) derivatives	871:910	The differences between the spectra of the nanocomposites and the pure precursors indicate that interactions between the components are stronger for the ionic poly(methacrylate) derivatives than for the neutral counterpart.
32272703	0	48	theme	Neutral	80:86	arg1	Derivatives					117:127	Neutral and ionic Poly(methacrylate) Derivatives	80:127	Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations	80:183	Understanding the Structure and Dynamics of Nanocellulose-Based Composites with Neutral and ionic Poly(methacrylate) Derivatives using Inelastic Neutron Scattering and DFT Calculations.
32272703	1	49	theme	neutron	404:410	arg1	INS					424:426	INS	424:426	INS	424:426	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	49	theme	neutron	404:410	arg1	scattering					412:421	inelastic neutron scattering	394:421	inelastic neutron scattering (INS) spectroscopy	394:440	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	2	50	theme	possible	701:708	arg1	structures					710:719	the possible structures	697:719	the possible structures	697:719	A reasonable match between calculated and experimental spectral lines and their intensities was used to support the vibrational assignment of the observed bands and to validate the possible structures.
32272703	2	51	used	used	616:619	arg2	reasonable					522:531	reasonable	522:531	reasonable	522:531	A reasonable match between calculated and experimental spectral lines and their intensities was used to support the vibrational assignment of the observed bands and to validate the possible structures.
32272703	5	52	theme	simple	1281:1286	arg1	mixtures					1288:1295	simple mixtures	1281:1295	simple mixtures of totally independent domains	1281:1326	Hence, the INS is an adequate technique to delve deeper into the structure and dynamics of nanocellulose-based composites, confirming that they are true nanocomposite materials instead of simple mixtures of totally independent domains.
32272703	3	53	theme	nanocomposites	765:778	arg1	spectra					750:756	the spectra	746:756	the spectra of the nanocomposites	746:778	The differences between the spectra of the nanocomposites and the pure precursors indicate that interactions between the components are stronger for the ionic poly(methacrylate) derivatives than for the neutral counterpart.
32272703	3	53	theme	nanocomposites	765:778	arg1	precursors					793:802	the pure precursors	784:802	the pure precursors	784:802	The differences between the spectra of the nanocomposites and the pure precursors indicate that interactions between the components are stronger for the ionic poly(methacrylate) derivatives than for the neutral counterpart.
32272703	2	54	dep	reasonable	522:531	arg1	match					533:537	match	533:537	match	533:537	A reasonable match between calculated and experimental spectral lines and their intensities was used to support the vibrational assignment of the observed bands and to validate the possible structures.
32272703	1	55	theme	2-hydroxyethyl	248:261	arg1	poly					243:246	poly	243:246	poly(2-hydroxyethyl methacrylate) (PHEMA)	243:283	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
32272703	1	55	theme	2-hydroxyethyl	248:261	arg1	methacrylate					263:274	2-hydroxyethyl methacrylate	248:274	2-hydroxyethyl methacrylate	248:274	Bacterial nanocellulose (BC)-based composites containing poly(2-hydroxyethyl methacrylate) (PHEMA), poly(methacroylcholine chloride) (PMACC) or poly(methacroylcholine hydroxide) (PMACH) were characterized by inelastic neutron scattering (INS) spectroscopy, combined with DFT (density functional theory) calculations of model systems.
33122057	5	0	link	hydration-linked	864:879	arg1	transitions					905:915	slow and hydration-linked hyaluronan conformation transitions	855:915	slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact	855:1045	These findings were attributed to slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact.
33122057	1	1	theme	hyaluronan	152:161	arg1	solutions					163:171	hyaluronan solutions	152:171	hyaluronan solutions of various compositions	152:195	Ultrasound velocity was measured in hyaluronan solutions of various compositions at different temperatures.
33122057	2	2	from	linear	312:317	arg1	NaCl					347:350	0.15 M NaCl	340:350	0.15 M NaCl regardless of hyaluronan molecular weight	340:392	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	2	2	from	linear	312:317	arg1	water					327:331	water	327:331	water	327:331	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	2	3	from	water	327:331	arg1	dependence					237:246	The velocity dependence	224:246	The velocity dependence on hyaluronan concentration at constant temperature (25 °C)	224:306	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	2	3	from	water	327:331	arg1	linear					312:317	linear	312:317	linear	312:317	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	0	4	from	Hysteresis	0:9	arg1	water					65:69	water	65:69	water	65:69	Hysteresis during heating and cooling of hyaluronan solutions in water observed by means of ultrasound velocimetry.
33122057	4	5	theme	NaCl	618:621	arg1	solutions					623:631	NaCl solutions	618:631	NaCl solutions	618:631	In NaCl solutions, the hysteresis was suppressed and, in contrast to solutions in water where the velocity demonstrated a local maximum with temperature, the velocity decreased with increasing temperature.
33122057	2	6	from	NaCl	347:350	arg1	linear					312:317	linear	312:317	linear	312:317	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	3	7	theme	aqueous	570:576	arg1	solutions					578:586	aqueous solutions	570:586	aqueous solutions for all molecular weights	570:612	During cyclic heating and cooling, hysteresis on the temperature dependence of ultrasound velocity was observed in the range 30-55 °C in aqueous solutions for all molecular weights.
33122057	2	8	from	dependence	237:246	arg1	concentration					262:274	hyaluronan concentration	251:274	hyaluronan concentration	251:274	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	5	9	theme	conformation	892:903	arg1	transitions					905:915	slow and hydration-linked hyaluronan conformation transitions	855:915	slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact	855:1045	These findings were attributed to slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact.
33122057	4	10	from	solutions	684:692	arg1	water					697:701	water	697:701	water where the velocity demonstrated a local maximum with temperature	697:766	In NaCl solutions, the hysteresis was suppressed and, in contrast to solutions in water where the velocity demonstrated a local maximum with temperature, the velocity decreased with increasing temperature.
33122057	3	11	from	30-55 °C	558:565	arg1	solutions					578:586	aqueous solutions	570:586	aqueous solutions for all molecular weights	570:612	During cyclic heating and cooling, hysteresis on the temperature dependence of ultrasound velocity was observed in the range 30-55 °C in aqueous solutions for all molecular weights.
33122057	2	12	theme	diluted-solution	406:421	arg1	behavior					423:430	diluted-solution behavior	406:430	diluted-solution behavior	406:430	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	0	13	theme	ultrasound	92:101	arg1	velocimetry					103:113	ultrasound velocimetry	92:113	ultrasound velocimetry	92:113	Hysteresis during heating and cooling of hyaluronan solutions in water observed by means of ultrasound velocimetry.
33122057	3	14	theme	30-55 °C	558:565	arg1	range					552:556	the range	548:556	the range 30-55 °C in aqueous solutions for all molecular weights	548:612	During cyclic heating and cooling, hysteresis on the temperature dependence of ultrasound velocity was observed in the range 30-55 °C in aqueous solutions for all molecular weights.
33122057	1	15	theme	various	176:182	arg1	compositions					184:195	various compositions	176:195	various compositions	176:195	Ultrasound velocity was measured in hyaluronan solutions of various compositions at different temperatures.
33122057	1	16	theme	compositions	184:195	arg1	solutions					163:171	hyaluronan solutions	152:171	hyaluronan solutions of various compositions	152:195	Ultrasound velocity was measured in hyaluronan solutions of various compositions at different temperatures.
33122057	3	17	theme	molecular	596:604	arg1	weights					606:612	all molecular weights	592:612	all molecular weights	592:612	During cyclic heating and cooling, hysteresis on the temperature dependence of ultrasound velocity was observed in the range 30-55 °C in aqueous solutions for all molecular weights.
33122057	5	18	theme	salt	983:986	arg1	presence					971:978	the presence	967:978	the presence	967:978	These findings were attributed to slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact.
33122057	1	19	theme	different	200:208	arg1	temperatures					210:221	different temperatures	200:221	different temperatures	200:221	Ultrasound velocity was measured in hyaluronan solutions of various compositions at different temperatures.
33122057	5	20	from	cooling	924:930	arg1	water					935:939	water	935:939	water	935:939	These findings were attributed to slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact.
33122057	3	21	theme	velocity	523:530	arg1	dependence					498:507	the temperature dependence	482:507	the temperature dependence of ultrasound velocity	482:530	During cyclic heating and cooling, hysteresis on the temperature dependence of ultrasound velocity was observed in the range 30-55 °C in aqueous solutions for all molecular weights.
33122057	2	22	from	temperature	288:298	arg1	dependence					237:246	The velocity dependence	224:246	The velocity dependence on hyaluronan concentration at constant temperature (25 °C)	224:306	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	2	22	from	temperature	288:298	arg1	linear					312:317	linear	312:317	linear	312:317	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	3	23	theme	temperature	486:496	arg1	dependence					498:507	the temperature dependence	482:507	the temperature dependence of ultrasound velocity	482:530	During cyclic heating and cooling, hysteresis on the temperature dependence of ultrasound velocity was observed in the range 30-55 °C in aqueous solutions for all molecular weights.
33122057	2	24	theme	0.15 M	340:345	arg1	NaCl					347:350	0.15 M NaCl	340:350	0.15 M NaCl regardless of hyaluronan molecular weight	340:392	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	2	25	theme	hyaluronan	251:260	arg1	concentration					262:274	hyaluronan concentration	251:274	hyaluronan concentration	251:274	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	5	26	theme	hydration-linked	864:879	arg1	transitions					905:915	slow and hydration-linked hyaluronan conformation transitions	855:915	slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact	855:1045	These findings were attributed to slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact.
33122057	3	27	theme	cyclic	440:445	arg1	heating					447:453	cyclic heating	440:453	cyclic heating	440:453	During cyclic heating and cooling, hysteresis on the temperature dependence of ultrasound velocity was observed in the range 30-55 °C in aqueous solutions for all molecular weights.
33122057	3	28	from	hysteresis	468:477	arg1	dependence					498:507	the temperature dependence	482:507	the temperature dependence of ultrasound velocity	482:530	During cyclic heating and cooling, hysteresis on the temperature dependence of ultrasound velocity was observed in the range 30-55 °C in aqueous solutions for all molecular weights.
33122057	5	29	theme	hyaluronan	881:890	arg1	transitions					905:915	slow and hydration-linked hyaluronan conformation transitions	855:915	slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact	855:1045	These findings were attributed to slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact.
33122057	0	30	theme	solutions	52:60	arg1	heating					18:24	heating	18:24	heating	18:24	Hysteresis during heating and cooling of hyaluronan solutions in water observed by means of ultrasound velocimetry.
33122057	0	30	theme	solutions	52:60	arg1	cooling					30:36	cooling	30:36	cooling	30:36	Hysteresis during heating and cooling of hyaluronan solutions in water observed by means of ultrasound velocimetry.
33122057	3	31	theme	ultrasound	512:521	arg1	velocity					523:530	ultrasound velocity	512:530	ultrasound velocity	512:530	During cyclic heating and cooling, hysteresis on the temperature dependence of ultrasound velocity was observed in the range 30-55 °C in aqueous solutions for all molecular weights.
33122057	0	32	theme	hyaluronan	41:50	arg1	solutions					52:60	hyaluronan solutions	41:60	hyaluronan solutions	41:60	Hysteresis during heating and cooling of hyaluronan solutions in water observed by means of ultrasound velocimetry.
33122057	2	33	theme	velocity	228:235	arg1	dependence					237:246	The velocity dependence	224:246	The velocity dependence on hyaluronan concentration at constant temperature (25 °C)	224:306	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	2	33	theme	velocity	228:235	arg1	linear					312:317	linear	312:317	linear	312:317	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	3	34	located	observed	536:543	arg1	range					552:556	the range	548:556	the range 30-55 °C in aqueous solutions for all molecular weights	548:612	During cyclic heating and cooling, hysteresis on the temperature dependence of ultrasound velocity was observed in the range 30-55 °C in aqueous solutions for all molecular weights.
33122057	3	34	located	observed	536:543	arg2	hysteresis					468:477	hysteresis	468:477	hysteresis on the temperature dependence of ultrasound velocity	468:530	During cyclic heating and cooling, hysteresis on the temperature dependence of ultrasound velocity was observed in the range 30-55 °C in aqueous solutions for all molecular weights.
33122057	1	35	theme	Ultrasound	116:125	arg1	velocity					127:134	Ultrasound velocity	116:134	Ultrasound velocity	116:134	Ultrasound velocity was measured in hyaluronan solutions of various compositions at different temperatures.
33122057	3	36	from	solutions	578:586	arg1	30-55 °C					558:565	30-55 °C	558:565	30-55 °C	558:565	During cyclic heating and cooling, hysteresis on the temperature dependence of ultrasound velocity was observed in the range 30-55 °C in aqueous solutions for all molecular weights.
33122057	5	37	theme	coiled	1014:1019	arg1	conformation					1021:1032	hyaluronan's coiled conformation	1001:1032	hyaluronan's coiled conformation more compact	1001:1045	These findings were attributed to slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact.
33122057	4	38	dep	solutions	684:692	arg1	contrast					672:679	contrast	672:679	contrast	672:679	In NaCl solutions, the hysteresis was suppressed and, in contrast to solutions in water where the velocity demonstrated a local maximum with temperature, the velocity decreased with increasing temperature.
33122057	4	39	theme	local	737:741	arg1	maximum					743:749	a local maximum	735:749	a local maximum	735:749	In NaCl solutions, the hysteresis was suppressed and, in contrast to solutions in water where the velocity demonstrated a local maximum with temperature, the velocity decreased with increasing temperature.
33122057	2	40	theme	constant	279:286	arg1	25 °C					301:305	25 °C	301:305	25 °C	301:305	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	2	40	theme	constant	279:286	arg1	temperature					288:298	constant temperature	279:298	constant temperature (25 °C)	279:306	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	5	41	theme	slow	855:858	arg1	transitions					905:915	slow and hydration-linked hyaluronan conformation transitions	855:915	slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact	855:1045	These findings were attributed to slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact.
33122057	2	42	theme	molecular	377:385	arg1	weight					387:392	hyaluronan molecular weight	366:392	hyaluronan molecular weight	366:392	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
33122057	5	43	theme	compact	1039:1045	arg1	conformation					1021:1032	hyaluronan's coiled conformation	1001:1032	hyaluronan's coiled conformation more compact	1001:1045	These findings were attributed to slow and hydration-linked hyaluronan conformation transitions during cooling in water, which were suppressed by the presence of salt, which makes hyaluronan's coiled conformation more compact.
33122057	2	44	theme	hyaluronan	366:375	arg1	weight					387:392	hyaluronan molecular weight	366:392	hyaluronan molecular weight	366:392	The velocity dependence on hyaluronan concentration at constant temperature (25 °C) was linear both in water and in 0.15 M NaCl regardless of hyaluronan molecular weight, confirming diluted-solution behavior.
32479939	8	0	theme	promising	1037:1045	arg1	dressing					1055:1062	a promising medical dressing	1035:1062	a promising medical dressing	1035:1062	Our results indicated that the composite hydrogel was a promising medical dressing and had the potential to promote wound healing.
32479939	8	0	theme	promising	1037:1045	arg1	hydrogel					1022:1029	the composite hydrogel	1008:1029	the composite hydrogel	1008:1029	Our results indicated that the composite hydrogel was a promising medical dressing and had the potential to promote wound healing.
32479939	0	1	with	hydrogel	40:47	arg1	synergism					68:76	wound healing synergism	54:76	wound healing synergism	54:76	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	3	2	theme	fenugreek	503:511	arg1	gum					513:515	fenugreek gum	503:515	fenugreek gum	503:515	Herein, we developed a novel composite polysaccharide hydrogel from fenugreek gum and cellulose.
32479939	0	3	theme	Facile	79:84	arg1	preparation					86:96	Facile preparation	79:96	Facile preparation	79:96	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	6	4	theme	composite	819:827	arg1	hydrogel					829:836	the composite hydrogel	815:836	the composite hydrogel	815:836	Furthermore, the composite hydrogel demonstrated good biocompatibility in vitro and in vivo.
32479939	1	5	theme	wound	263:267	arg1	hemostasis					269:278	wound hemostasis	263:278	wound hemostasis	263:278	Hydrogels can be used as bioactive dressings, which outperform traditional dressings and are widely used in wound hemostasis and healing.
32479939	5	6	theme	thermal	729:735	arg1	stability					737:745	thermal stability	729:745	thermal stability	729:745	The composite hydrogel had a porous structure, thermal stability, good water absorption and a sustained release effect.
32479939	3	7	from	gum	513:515	arg1	hydrogel					489:496	a novel composite polysaccharide hydrogel	456:496	a novel composite polysaccharide hydrogel from fenugreek gum and cellulose	456:529	Herein, we developed a novel composite polysaccharide hydrogel from fenugreek gum and cellulose.
32479939	1	8	used	used	172:175	arg2	Hydrogels					155:163	Hydrogels	155:163	Hydrogels	155:163	Hydrogels can be used as bioactive dressings, which outperform traditional dressings and are widely used in wound hemostasis and healing.
32479939	1	8	used	used	172:175	arg2	dressings					190:198	bioactive dressings	180:198	bioactive dressings	180:198	Hydrogels can be used as bioactive dressings, which outperform traditional dressings and are widely used in wound hemostasis and healing.
32479939	8	9	theme	medical	1047:1053	arg1	dressing					1055:1062	a promising medical dressing	1035:1062	a promising medical dressing	1035:1062	Our results indicated that the composite hydrogel was a promising medical dressing and had the potential to promote wound healing.
32479939	8	9	theme	medical	1047:1053	arg1	hydrogel					1022:1029	the composite hydrogel	1008:1029	the composite hydrogel	1008:1029	Our results indicated that the composite hydrogel was a promising medical dressing and had the potential to promote wound healing.
32479939	0	10	theme	wound	120:124	arg1	healing					126:132	wound healing	120:132	wound healing	120:132	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	3	11	from	cellulose	521:529	arg1	hydrogel					489:496	a novel composite polysaccharide hydrogel	456:496	a novel composite polysaccharide hydrogel from fenugreek gum and cellulose	456:529	Herein, we developed a novel composite polysaccharide hydrogel from fenugreek gum and cellulose.
32479939	4	12	theme	composite	662:670	arg1	hydrogel					672:679	the composite hydrogel	658:679	the composite hydrogel	658:679	Fenugreek gum was combined with cellulose through hydrogen bonding to form a hydrogel to improve the mechanical properties of the composite hydrogel.
32479939	5	13	theme	good	748:751	arg1	absorption					759:768	good water absorption	748:768	good water absorption	748:768	The composite hydrogel had a porous structure, thermal stability, good water absorption and a sustained release effect.
32479939	8	14	contain	had	1068:1070	arg2	potential					1076:1084	the potential to promote wound healing	1072:1109	the potential to promote wound healing	1072:1109	Our results indicated that the composite hydrogel was a promising medical dressing and had the potential to promote wound healing.
32479939	8	14	contain	had	1068:1070	arg1	dressing					1055:1062	a promising medical dressing	1035:1062	a promising medical dressing	1035:1062	Our results indicated that the composite hydrogel was a promising medical dressing and had the potential to promote wound healing.
32479939	8	14	contain	had	1068:1070	arg1	hydrogel					1022:1029	the composite hydrogel	1008:1029	the composite hydrogel	1008:1029	Our results indicated that the composite hydrogel was a promising medical dressing and had the potential to promote wound healing.
32479939	8	15	theme	composite	1012:1020	arg1	dressing					1055:1062	a promising medical dressing	1035:1062	a promising medical dressing	1035:1062	Our results indicated that the composite hydrogel was a promising medical dressing and had the potential to promote wound healing.
32479939	8	15	theme	composite	1012:1020	arg1	hydrogel					1022:1029	the composite hydrogel	1008:1029	the composite hydrogel	1008:1029	Our results indicated that the composite hydrogel was a promising medical dressing and had the potential to promote wound healing.
32479939	1	16	theme	bioactive	180:188	arg1	dressings					190:198	bioactive dressings	180:198	bioactive dressings	180:198	Hydrogels can be used as bioactive dressings, which outperform traditional dressings and are widely used in wound hemostasis and healing.
32479939	1	16	theme	bioactive	180:188	arg1	Hydrogels					155:163	Hydrogels	155:163	Hydrogels	155:163	Hydrogels can be used as bioactive dressings, which outperform traditional dressings and are widely used in wound hemostasis and healing.
32479939	0	17	theme	fenugreek	6:14	arg1	hydrogel					40:47	Novel fenugreek gum-cellulose composite hydrogel	0:47	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.	0:153	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	7	18	theme	healing	953:959	arg1	performance					917:927	the superior performance	904:927	the superior performance of wound hemostasis and healing	904:959	Notably, the superior performance of wound hemostasis and healing has been confirmed.
32479939	0	19	dep	preparation	86:96	arg1	evaluation					143:152	activity evaluation	134:152	activity evaluation	134:152	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	2	20	theme	strong	372:377	arg1	properties					390:399	strong mechanical properties	372:399	strong mechanical properties	372:399	However, it is still a challenge to develop a hydrogel with good stability and strong mechanical properties for wound hemostasis and healing.
32479939	0	21	theme	Novel	0:4	arg1	hydrogel					40:47	Novel fenugreek gum-cellulose composite hydrogel	0:47	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.	0:153	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	7	22	theme	wound	932:936	arg1	hemostasis					938:947	wound hemostasis	932:947	wound hemostasis	932:947	Notably, the superior performance of wound hemostasis and healing has been confirmed.
32479939	4	23	theme	hydrogel	672:679	arg1	properties					644:653	the mechanical properties	629:653	the mechanical properties of the composite hydrogel	629:679	Fenugreek gum was combined with cellulose through hydrogen bonding to form a hydrogel to improve the mechanical properties of the composite hydrogel.
32479939	0	24	theme	composite	30:38	arg1	hydrogel					40:47	Novel fenugreek gum-cellulose composite hydrogel	0:47	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.	0:153	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	0	25	theme	activity	134:141	arg1	evaluation					143:152	activity evaluation	134:152	activity evaluation	134:152	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	7	26	theme	hemostasis	938:947	arg1	performance					917:927	the superior performance	904:927	the superior performance of wound hemostasis and healing	904:959	Notably, the superior performance of wound hemostasis and healing has been confirmed.
32479939	4	27	theme	mechanical	633:642	arg1	properties					644:653	the mechanical properties	629:653	the mechanical properties of the composite hydrogel	629:679	Fenugreek gum was combined with cellulose through hydrogen bonding to form a hydrogel to improve the mechanical properties of the composite hydrogel.
32479939	0	28	theme	gum-cellulose	16:28	arg1	hydrogel					40:47	Novel fenugreek gum-cellulose composite hydrogel	0:47	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.	0:153	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	5	29	theme	porous	711:716	arg1	structure					718:726	a porous structure	709:726	a porous structure	709:726	The composite hydrogel had a porous structure, thermal stability, good water absorption and a sustained release effect.
32479939	3	30	theme	novel	458:462	arg1	hydrogel					489:496	a novel composite polysaccharide hydrogel	456:496	a novel composite polysaccharide hydrogel from fenugreek gum and cellulose	456:529	Herein, we developed a novel composite polysaccharide hydrogel from fenugreek gum and cellulose.
32479939	5	31	theme	sustained	776:784	arg1	effect					794:799	a sustained release effect	774:799	a sustained release effect	774:799	The composite hydrogel had a porous structure, thermal stability, good water absorption and a sustained release effect.
32479939	1	32	theme	traditional	218:228	arg1	dressings					230:238	traditional dressings	218:238	traditional dressings	218:238	Hydrogels can be used as bioactive dressings, which outperform traditional dressings and are widely used in wound hemostasis and healing.
32479939	7	33	theme	superior	908:915	arg1	performance					917:927	the superior performance	904:927	the superior performance of wound hemostasis and healing	904:959	Notably, the superior performance of wound hemostasis and healing has been confirmed.
32479939	2	34	theme	wound	405:409	arg1	hemostasis					411:420	wound hemostasis	405:420	wound hemostasis	405:420	However, it is still a challenge to develop a hydrogel with good stability and strong mechanical properties for wound hemostasis and healing.
32479939	5	35	theme	release	786:792	arg1	effect					794:799	a sustained release effect	774:799	a sustained release effect	774:799	The composite hydrogel had a porous structure, thermal stability, good water absorption and a sustained release effect.
32479939	4	36	theme	Fenugreek	532:540	arg1	gum					542:544	Fenugreek gum	532:544	Fenugreek gum	532:544	Fenugreek gum was combined with cellulose through hydrogen bonding to form a hydrogel to improve the mechanical properties of the composite hydrogel.
32479939	4	37	theme	hydrogen	582:589	arg1	bonding					591:597	hydrogen bonding	582:597	hydrogen bonding to form a hydrogel to improve the mechanical properties of the composite hydrogel	582:679	Fenugreek gum was combined with cellulose through hydrogen bonding to form a hydrogel to improve the mechanical properties of the composite hydrogel.
32479939	0	38	theme	healing	60:66	arg1	synergism					68:76	wound healing synergism	54:76	wound healing synergism	54:76	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	5	39	contain	had	705:707	arg1	hydrogel					696:703	The composite hydrogel	682:703	The composite hydrogel	682:703	The composite hydrogel had a porous structure, thermal stability, good water absorption and a sustained release effect.
32479939	5	39	contain	had	705:707	arg2	absorption					759:768	good water absorption	748:768	good water absorption	748:768	The composite hydrogel had a porous structure, thermal stability, good water absorption and a sustained release effect.
32479939	5	39	contain	had	705:707	arg2	structure					718:726	a porous structure	709:726	a porous structure	709:726	The composite hydrogel had a porous structure, thermal stability, good water absorption and a sustained release effect.
32479939	5	39	contain	had	705:707	arg2	stability					737:745	thermal stability	729:745	thermal stability	729:745	The composite hydrogel had a porous structure, thermal stability, good water absorption and a sustained release effect.
32479939	5	39	contain	had	705:707	arg2	effect					794:799	a sustained release effect	774:799	a sustained release effect	774:799	The composite hydrogel had a porous structure, thermal stability, good water absorption and a sustained release effect.
32479939	6	40	theme	good	851:854	arg1	biocompatibility					856:871	good biocompatibility	851:871	good biocompatibility	851:871	Furthermore, the composite hydrogel demonstrated good biocompatibility in vitro and in vivo.
32479939	0	41	theme	wound	54:58	arg1	healing					60:66	wound healing	54:66	wound healing synergism	54:76	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	5	42	theme	composite	686:694	arg1	hydrogel					696:703	The composite hydrogel	682:703	The composite hydrogel	682:703	The composite hydrogel had a porous structure, thermal stability, good water absorption and a sustained release effect.
32479939	1	43	used	used	255:258	arg2	Hydrogels					155:163	Hydrogels	155:163	Hydrogels	155:163	Hydrogels can be used as bioactive dressings, which outperform traditional dressings and are widely used in wound hemostasis and healing.
32479939	1	43	used	used	255:258	arg2	dressings					190:198	bioactive dressings	180:198	bioactive dressings	180:198	Hydrogels can be used as bioactive dressings, which outperform traditional dressings and are widely used in wound hemostasis and healing.
32479939	0	44	dep	hydrogel	40:47	arg1	characterization					99:114	characterization	99:114	characterization	99:114	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	0	44	dep	hydrogel	40:47	arg1	healing					126:132	wound healing	120:132	wound healing	120:132	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	0	44	dep	hydrogel	40:47	arg1	preparation					86:96	Facile preparation	79:96	Facile preparation	79:96	Novel fenugreek gum-cellulose composite hydrogel with wound healing synergism: Facile preparation, characterization and wound healing activity evaluation.
32479939	2	45	with	hydrogel	339:346	arg1	properties					390:399	strong mechanical properties	372:399	strong mechanical properties	372:399	However, it is still a challenge to develop a hydrogel with good stability and strong mechanical properties for wound hemostasis and healing.
32479939	2	45	with	hydrogel	339:346	arg1	stability					358:366	good stability	353:366	good stability	353:366	However, it is still a challenge to develop a hydrogel with good stability and strong mechanical properties for wound hemostasis and healing.
32479939	3	46	theme	composite	464:472	arg1	hydrogel					489:496	a novel composite polysaccharide hydrogel	456:496	a novel composite polysaccharide hydrogel from fenugreek gum and cellulose	456:529	Herein, we developed a novel composite polysaccharide hydrogel from fenugreek gum and cellulose.
32479939	3	47	theme	polysaccharide	474:487	arg1	hydrogel					489:496	a novel composite polysaccharide hydrogel	456:496	a novel composite polysaccharide hydrogel from fenugreek gum and cellulose	456:529	Herein, we developed a novel composite polysaccharide hydrogel from fenugreek gum and cellulose.
32479939	5	48	theme	water	753:757	arg1	absorption					759:768	good water absorption	748:768	good water absorption	748:768	The composite hydrogel had a porous structure, thermal stability, good water absorption and a sustained release effect.
32479939	2	49	theme	mechanical	379:388	arg1	properties					390:399	strong mechanical properties	372:399	strong mechanical properties	372:399	However, it is still a challenge to develop a hydrogel with good stability and strong mechanical properties for wound hemostasis and healing.
32479939	2	50	theme	good	353:356	arg1	stability					358:366	good stability	353:366	good stability	353:366	However, it is still a challenge to develop a hydrogel with good stability and strong mechanical properties for wound hemostasis and healing.
32479939	8	51	theme	wound	1097:1101	arg1	healing					1103:1109	wound healing	1097:1109	wound healing	1097:1109	Our results indicated that the composite hydrogel was a promising medical dressing and had the potential to promote wound healing.
34364586	8	0	dep	properties	1146:1155	arg1	the					1126:1128	the	1126:1128	the	1126:1128	We provide new insights on the physicochemical properties and water-regulation effects of wheat cell wall.
34364586	2	1	theme	growth	288:293	arg1	stages					295:300	three growth stages	282:300	three growth stages	282:300	AX was extracted from wheat at three growth stages and single-component and alternate overlapping multilayer films were prepared.
34364586	4	2	theme	significant	531:541	arg1	differences					543:553	significant differences	531:553	significant differences in the AX content and arabinose-to-xylose ratio at different growth stages	531:628	There were significant differences in the AX content and arabinose-to-xylose ratio at different growth stages.
34364586	5	3	theme	relative	744:751	arg1	humidity					753:760	the relative humidity	740:760	the relative humidity	740:760	The LAX/BG multilayer films showed excellent thermal stability and mechanical properties with an increase in the relative humidity.
34364586	6	4	theme	substitution	798:809	arg1	rate					811:814	a low substitution rate	792:814	a low substitution rate	792:814	The AX multilayer films with a low substitution rate showed a better water-binding capacity, whereas water molecules in films with a high substitution rate showed higher mobility.
34364586	8	5	theme	wall	1200:1203	arg1	effects					1178:1184	water-regulation effects	1161:1184	water-regulation effects	1161:1184	We provide new insights on the physicochemical properties and water-regulation effects of wheat cell wall.
34364586	8	5	theme	wall	1200:1203	arg1	properties					1146:1155	physicochemical properties	1130:1155	physicochemical properties	1130:1155	We provide new insights on the physicochemical properties and water-regulation effects of wheat cell wall.
34364586	3	6	theme	multilayer	450:459	arg1	films					461:465	multilayer films	450:465	multilayer films	450:465	The physical properties, water diffusion rate, and water mobility of multilayer films during water absorption and desorption were studied.
34364586	5	7	theme	mechanical	698:707	arg1	properties					709:718	mechanical properties	698:718	mechanical properties	698:718	The LAX/BG multilayer films showed excellent thermal stability and mechanical properties with an increase in the relative humidity.
34364586	0	8	from	Effects	0:6	arg1	properties					75:84	the properties	71:84	the properties of films simulating wheat grain	71:116	Effects of lamellar organization and arabinoxylan substitution rate on the properties of films simulating wheat grain aleurone cell wall.
34364586	6	9	with	films	883:887	arg1	rate					914:917	a high substitution rate	894:917	a high substitution rate	894:917	The AX multilayer films with a low substitution rate showed a better water-binding capacity, whereas water molecules in films with a high substitution rate showed higher mobility.
34364586	0	10	theme	films	89:93	arg1	properties					75:84	the properties	71:84	the properties of films simulating wheat grain	71:116	Effects of lamellar organization and arabinoxylan substitution rate on the properties of films simulating wheat grain aleurone cell wall.
34364586	7	11	theme	water	1083:1087	arg1	mobility					1089:1096	water mobility	1083:1096	water mobility	1083:1096	Therefore, a low substitution rate AX and AX/BG composite structure can improve the thermodynamic properties of multilayer films, but limit water mobility.
34364586	1	12	theme	-β-D-glucan	216:226	arg1	films					244:248	alternate arabinoxylan (AX)/(1→3) (1→4)-β-D-glucan (BG) multilayer films	177:248	alternate arabinoxylan (AX)/(1→3) (1→4)-β-D-glucan (BG) multilayer films	177:248	Herein, we evaluated the properties of alternate arabinoxylan (AX)/(1→3) (1→4)-β-D-glucan (BG) multilayer films.
34364586	6	13	from	molecules	870:878	arg1	films					883:887	films	883:887	films with a high substitution rate	883:917	The AX multilayer films with a low substitution rate showed a better water-binding capacity, whereas water molecules in films with a high substitution rate showed higher mobility.
34364586	6	14	theme	water	864:868	arg1	molecules					870:878	water molecules	864:878	water molecules in films with a high substitution rate	864:917	The AX multilayer films with a low substitution rate showed a better water-binding capacity, whereas water molecules in films with a high substitution rate showed higher mobility.
34364586	6	15	theme	multilayer	770:779	arg1	films					781:785	The AX multilayer films	763:785	The AX multilayer films with a low substitution rate	763:814	The AX multilayer films with a low substitution rate showed a better water-binding capacity, whereas water molecules in films with a high substitution rate showed higher mobility.
34364586	3	16	theme	water	474:478	arg1	absorption					480:489	water absorption	474:489	water absorption	474:489	The physical properties, water diffusion rate, and water mobility of multilayer films during water absorption and desorption were studied.
34364586	2	17	theme	overlapping	337:347	arg1	films					360:364	single-component and alternate overlapping multilayer films	306:364	single-component and alternate overlapping multilayer films	306:364	AX was extracted from wheat at three growth stages and single-component and alternate overlapping multilayer films were prepared.
34364586	0	18	theme	wheat	106:110	arg1	grain					112:116	wheat grain	106:116	wheat grain	106:116	Effects of lamellar organization and arabinoxylan substitution rate on the properties of films simulating wheat grain aleurone cell wall.
34364586	8	19	theme	cell	1195:1198	arg1	wall					1200:1203	wheat cell wall	1189:1203	wheat cell wall	1189:1203	We provide new insights on the physicochemical properties and water-regulation effects of wheat cell wall.
34364586	6	20	theme	AX	767:768	arg1	films					781:785	The AX multilayer films	763:785	The AX multilayer films with a low substitution rate	763:814	The AX multilayer films with a low substitution rate showed a better water-binding capacity, whereas water molecules in films with a high substitution rate showed higher mobility.
34364586	4	21	from	stages	623:628	arg1	differences					543:553	significant differences	531:553	significant differences in the AX content and arabinose-to-xylose ratio at different growth stages	531:628	There were significant differences in the AX content and arabinose-to-xylose ratio at different growth stages.
34364586	4	21	from	stages	623:628	arg1	content					565:571	AX content	562:571	AX content	562:571	There were significant differences in the AX content and arabinose-to-xylose ratio at different growth stages.
34364586	4	21	from	stages	623:628	arg1	ratio					597:601	arabinose-to-xylose ratio	577:601	arabinose-to-xylose ratio	577:601	There were significant differences in the AX content and arabinose-to-xylose ratio at different growth stages.
34364586	2	22	theme	alternate	327:335	arg1	films					360:364	single-component and alternate overlapping multilayer films	306:364	single-component and alternate overlapping multilayer films	306:364	AX was extracted from wheat at three growth stages and single-component and alternate overlapping multilayer films were prepared.
34364586	6	23	with	films	781:785	arg1	rate					811:814	a low substitution rate	792:814	a low substitution rate	792:814	The AX multilayer films with a low substitution rate showed a better water-binding capacity, whereas water molecules in films with a high substitution rate showed higher mobility.
34364586	6	24	theme	higher	926:931	arg1	mobility					933:940	higher mobility	926:940	higher mobility	926:940	The AX multilayer films with a low substitution rate showed a better water-binding capacity, whereas water molecules in films with a high substitution rate showed higher mobility.
34364586	7	25	theme	multilayer	1055:1064	arg1	films					1066:1070	multilayer films	1055:1070	multilayer films	1055:1070	Therefore, a low substitution rate AX and AX/BG composite structure can improve the thermodynamic properties of multilayer films, but limit water mobility.
34364586	6	26	theme	low	794:796	arg1	rate					811:814	a low substitution rate	792:814	a low substitution rate	792:814	The AX multilayer films with a low substitution rate showed a better water-binding capacity, whereas water molecules in films with a high substitution rate showed higher mobility.
34364586	2	27	theme	single-component	306:321	arg1	films					360:364	single-component and alternate overlapping multilayer films	306:364	single-component and alternate overlapping multilayer films	306:364	AX was extracted from wheat at three growth stages and single-component and alternate overlapping multilayer films were prepared.
34364586	0	28	theme	organization	20:31	arg1	Effects					0:6	Effects	0:6	Effects of lamellar organization and arabinoxylan substitution rate on the properties of films simulating wheat grain	0:116	Effects of lamellar organization and arabinoxylan substitution rate on the properties of films simulating wheat grain aleurone cell wall.
34364586	8	29	theme	physicochemical	1130:1144	arg1	properties					1146:1155	physicochemical properties	1130:1155	physicochemical properties	1130:1155	We provide new insights on the physicochemical properties and water-regulation effects of wheat cell wall.
34364586	0	30	theme	cell	127:130	arg1	wall					132:135	cell wall	127:135	cell wall	127:135	Effects of lamellar organization and arabinoxylan substitution rate on the properties of films simulating wheat grain aleurone cell wall.
34364586	3	31	theme	diffusion	412:420	arg1	rate					422:425	water diffusion rate	406:425	water diffusion rate	406:425	The physical properties, water diffusion rate, and water mobility of multilayer films during water absorption and desorption were studied.
34364586	0	32	theme	lamellar	11:18	arg1	organization					20:31	lamellar organization	11:31	lamellar organization	11:31	Effects of lamellar organization and arabinoxylan substitution rate on the properties of films simulating wheat grain aleurone cell wall.
34364586	5	33	theme	thermal	676:682	arg1	stability					684:692	excellent thermal stability	666:692	excellent thermal stability	666:692	The LAX/BG multilayer films showed excellent thermal stability and mechanical properties with an increase in the relative humidity.
34364586	8	34	from	insights	1114:1121	arg1	effects					1178:1184	water-regulation effects	1161:1184	water-regulation effects	1161:1184	We provide new insights on the physicochemical properties and water-regulation effects of wheat cell wall.
34364586	8	34	from	insights	1114:1121	arg1	properties					1146:1155	physicochemical properties	1130:1155	physicochemical properties	1130:1155	We provide new insights on the physicochemical properties and water-regulation effects of wheat cell wall.
34364586	8	35	theme	new	1110:1112	arg1	insights					1114:1121	new insights	1110:1121	new insights on the physicochemical properties and water-regulation effects of wheat cell wall	1110:1203	We provide new insights on the physicochemical properties and water-regulation effects of wheat cell wall.
34364586	4	36	theme	arabinose-to-xylose	577:595	arg1	ratio					597:601	arabinose-to-xylose ratio	577:601	arabinose-to-xylose ratio	577:601	There were significant differences in the AX content and arabinose-to-xylose ratio at different growth stages.
34364586	0	37	theme	arabinoxylan	37:48	arg1	rate					63:66	arabinoxylan substitution rate	37:66	arabinoxylan substitution rate	37:66	Effects of lamellar organization and arabinoxylan substitution rate on the properties of films simulating wheat grain aleurone cell wall.
34364586	1	38	theme	multilayer	233:242	arg1	films					244:248	alternate arabinoxylan (AX)/(1→3) (1→4)-β-D-glucan (BG) multilayer films	177:248	alternate arabinoxylan (AX)/(1→3) (1→4)-β-D-glucan (BG) multilayer films	177:248	Herein, we evaluated the properties of alternate arabinoxylan (AX)/(1→3) (1→4)-β-D-glucan (BG) multilayer films.
34364586	6	39	theme	water-binding	832:844	arg1	capacity					846:853	a better water-binding capacity	823:853	a better water-binding capacity	823:853	The AX multilayer films with a low substitution rate showed a better water-binding capacity, whereas water molecules in films with a high substitution rate showed higher mobility.
34364586	1	40	theme	alternate	177:185	arg1	arabinoxylan					187:198	alternate arabinoxylan	177:198	alternate arabinoxylan (AX)/(1→3)	177:209	Herein, we evaluated the properties of alternate arabinoxylan (AX)/(1→3) (1→4)-β-D-glucan (BG) multilayer films.
34364586	4	41	theme	different	606:614	arg1	stages					623:628	different growth stages	606:628	different growth stages	606:628	There were significant differences in the AX content and arabinose-to-xylose ratio at different growth stages.
34364586	3	42	theme	physical	385:392	arg1	properties					394:403	The physical properties	381:403	The physical properties	381:403	The physical properties, water diffusion rate, and water mobility of multilayer films during water absorption and desorption were studied.
34364586	1	43	theme	films	244:248	arg1	properties					163:172	the properties	159:172	the properties of alternate arabinoxylan (AX)/(1→3) (1→4)-β-D-glucan (BG) multilayer films	159:248	Herein, we evaluated the properties of alternate arabinoxylan (AX)/(1→3) (1→4)-β-D-glucan (BG) multilayer films.
34364586	7	44	theme	thermodynamic	1027:1039	arg1	properties					1041:1050	the thermodynamic properties	1023:1050	the thermodynamic properties of multilayer films	1023:1070	Therefore, a low substitution rate AX and AX/BG composite structure can improve the thermodynamic properties of multilayer films, but limit water mobility.
34364586	6	45	theme	better	825:830	arg1	capacity					846:853	a better water-binding capacity	823:853	a better water-binding capacity	823:853	The AX multilayer films with a low substitution rate showed a better water-binding capacity, whereas water molecules in films with a high substitution rate showed higher mobility.
34364586	2	46	theme	multilayer	349:358	arg1	films					360:364	single-component and alternate overlapping multilayer films	306:364	single-component and alternate overlapping multilayer films	306:364	AX was extracted from wheat at three growth stages and single-component and alternate overlapping multilayer films were prepared.
34364586	0	47	theme	rate	63:66	arg1	Effects					0:6	Effects	0:6	Effects of lamellar organization and arabinoxylan substitution rate on the properties of films simulating wheat grain	0:116	Effects of lamellar organization and arabinoxylan substitution rate on the properties of films simulating wheat grain aleurone cell wall.
34364586	5	48	theme	LAX/BG	635:640	arg1	films					653:657	The LAX/BG multilayer films	631:657	The LAX/BG multilayer films	631:657	The LAX/BG multilayer films showed excellent thermal stability and mechanical properties with an increase in the relative humidity.
34364586	7	49	theme	AX/BG	985:989	arg1	structure					1001:1009	AX/BG composite structure	985:1009	AX/BG composite structure	985:1009	Therefore, a low substitution rate AX and AX/BG composite structure can improve the thermodynamic properties of multilayer films, but limit water mobility.
34364586	3	50	theme	water	432:436	arg1	mobility					438:445	water mobility	432:445	water mobility	432:445	The physical properties, water diffusion rate, and water mobility of multilayer films during water absorption and desorption were studied.
34364586	0	51	theme	substitution	50:61	arg1	rate					63:66	arabinoxylan substitution rate	37:66	arabinoxylan substitution rate	37:66	Effects of lamellar organization and arabinoxylan substitution rate on the properties of films simulating wheat grain aleurone cell wall.
34364586	6	52	theme	substitution	901:912	arg1	rate					914:917	a high substitution rate	894:917	a high substitution rate	894:917	The AX multilayer films with a low substitution rate showed a better water-binding capacity, whereas water molecules in films with a high substitution rate showed higher mobility.
34364586	5	53	theme	multilayer	642:651	arg1	films					653:657	The LAX/BG multilayer films	631:657	The LAX/BG multilayer films	631:657	The LAX/BG multilayer films showed excellent thermal stability and mechanical properties with an increase in the relative humidity.
34364586	4	54	dep	content	565:571	arg1	the					558:560	the	558:560	the	558:560	There were significant differences in the AX content and arabinose-to-xylose ratio at different growth stages.
34364586	8	55	theme	wheat	1189:1193	arg1	wall					1200:1203	wheat cell wall	1189:1203	wheat cell wall	1189:1203	We provide new insights on the physicochemical properties and water-regulation effects of wheat cell wall.
34364586	6	56	theme	high	896:899	arg1	rate					914:917	a high substitution rate	894:917	a high substitution rate	894:917	The AX multilayer films with a low substitution rate showed a better water-binding capacity, whereas water molecules in films with a high substitution rate showed higher mobility.
34364586	7	57	theme	composite	991:999	arg1	structure					1001:1009	AX/BG composite structure	985:1009	AX/BG composite structure	985:1009	Therefore, a low substitution rate AX and AX/BG composite structure can improve the thermodynamic properties of multilayer films, but limit water mobility.
34364586	1	58	dep	-β-D-glucan	216:226	arg1	BG					229:230	BG	229:230	BG	229:230	Herein, we evaluated the properties of alternate arabinoxylan (AX)/(1→3) (1→4)-β-D-glucan (BG) multilayer films.
34364586	1	58	dep	-β-D-glucan	216:226	arg1	arabinoxylan					187:198	alternate arabinoxylan	177:198	alternate arabinoxylan (AX)/(1→3)	177:209	Herein, we evaluated the properties of alternate arabinoxylan (AX)/(1→3) (1→4)-β-D-glucan (BG) multilayer films.
34364586	7	59	theme	AX	978:979	arg1	rate					973:976	a low substitution rate AX	954:979	a low substitution rate AX	954:979	Therefore, a low substitution rate AX and AX/BG composite structure can improve the thermodynamic properties of multilayer films, but limit water mobility.
34364586	4	60	theme	AX	562:563	arg1	content					565:571	AX content	562:571	AX content	562:571	There were significant differences in the AX content and arabinose-to-xylose ratio at different growth stages.
34364586	5	61	from	increase	728:735	arg1	humidity					753:760	the relative humidity	740:760	the relative humidity	740:760	The LAX/BG multilayer films showed excellent thermal stability and mechanical properties with an increase in the relative humidity.
34364586	7	62	theme	low	956:958	arg1	rate					973:976	a low substitution rate AX	954:979	a low substitution rate AX	954:979	Therefore, a low substitution rate AX and AX/BG composite structure can improve the thermodynamic properties of multilayer films, but limit water mobility.
34364586	7	63	theme	films	1066:1070	arg1	properties					1041:1050	the thermodynamic properties	1023:1050	the thermodynamic properties of multilayer films	1023:1070	Therefore, a low substitution rate AX and AX/BG composite structure can improve the thermodynamic properties of multilayer films, but limit water mobility.
34364586	3	64	theme	water	406:410	arg1	rate					422:425	water diffusion rate	406:425	water diffusion rate	406:425	The physical properties, water diffusion rate, and water mobility of multilayer films during water absorption and desorption were studied.
34364586	1	65	dep	arabinoxylan	187:198	arg1	AX					201:202	AX	201:202	AX	201:202	Herein, we evaluated the properties of alternate arabinoxylan (AX)/(1→3) (1→4)-β-D-glucan (BG) multilayer films.
34364586	7	66	theme	substitution	960:971	arg1	rate					973:976	a low substitution rate AX	954:979	a low substitution rate AX	954:979	Therefore, a low substitution rate AX and AX/BG composite structure can improve the thermodynamic properties of multilayer films, but limit water mobility.
34364586	3	67	theme	films	461:465	arg1	rate					422:425	water diffusion rate	406:425	water diffusion rate	406:425	The physical properties, water diffusion rate, and water mobility of multilayer films during water absorption and desorption were studied.
34364586	3	67	theme	films	461:465	arg1	properties					394:403	The physical properties	381:403	The physical properties	381:403	The physical properties, water diffusion rate, and water mobility of multilayer films during water absorption and desorption were studied.
34364586	3	67	theme	films	461:465	arg1	mobility					438:445	water mobility	432:445	water mobility	432:445	The physical properties, water diffusion rate, and water mobility of multilayer films during water absorption and desorption were studied.
34364586	4	68	theme	growth	616:621	arg1	stages					623:628	different growth stages	606:628	different growth stages	606:628	There were significant differences in the AX content and arabinose-to-xylose ratio at different growth stages.
34364586	5	69	theme	excellent	666:674	arg1	stability					684:692	excellent thermal stability	666:692	excellent thermal stability	666:692	The LAX/BG multilayer films showed excellent thermal stability and mechanical properties with an increase in the relative humidity.
34364586	8	70	theme	water-regulation	1161:1176	arg1	effects					1178:1184	water-regulation effects	1161:1184	water-regulation effects	1161:1184	We provide new insights on the physicochemical properties and water-regulation effects of wheat cell wall.
34364586	4	71	from	differences	543:553	arg1	stages					623:628	different growth stages	606:628	different growth stages	606:628	There were significant differences in the AX content and arabinose-to-xylose ratio at different growth stages.
34364586	4	71	from	differences	543:553	arg1	content					565:571	AX content	562:571	AX content	562:571	There were significant differences in the AX content and arabinose-to-xylose ratio at different growth stages.
34364586	4	71	from	differences	543:553	arg1	ratio					597:601	arabinose-to-xylose ratio	577:601	arabinose-to-xylose ratio	577:601	There were significant differences in the AX content and arabinose-to-xylose ratio at different growth stages.
34740680	0	0	theme	sensory	91:97	arg1	slices					178:183	sensory, physical state, microbiota composition and quality of refrigerated grass carp slices	91:183	sensory, physical state, microbiota composition and quality of refrigerated grass carp slices	91:183	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	5	1	from	deterioration	965:977	arg1	fillets					1050:1056	fillets	1050:1056	fillets	1050:1056	In addition, coating also slowed down the deterioration of physical properties of color, texture and water holding capacity in fillets, giving fillets a better edible quality.
34740680	4	2	theme	basic	831:835	arg1	TVB-N					847:851	TVB-N	847:851	TVB-N	847:851	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	4	2	theme	basic	831:835	arg1	nitrogen					837:844	total volatile basic nitrogen	816:844	total volatile basic nitrogen (TVB-N)	816:852	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	2	3	theme	fillets	503:509	arg1	degradation					483:493	the quality degradation	471:493	the quality degradation of carp fillets	471:509	Generally, the quality degradation of carp fillets was remarkably alleviated using coatings when compared to the control.
34740680	7	4	theme	force	1535:1539	arg1	values					1519:1524	highest values	1511:1524	highest values of shear force and sensory preference among groups	1511:1575	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	7	4	theme	force	1535:1539	arg1	values					1459:1464	the lowest values	1448:1464	the lowest values of TVB-N, TBARS, K-value and water loss	1448:1504	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	6	5	theme	good	1246:1249	arg1	effect					1277:1282	a relatively good synergistic antibacterial effect	1233:1282	a relatively good synergistic antibacterial effect between chitosan and extracts	1233:1312	By contrast, the fillets treated by composite coatings had better quality during storage when compared to chitosan coating alone, and a relatively good synergistic antibacterial effect between chitosan and extracts was also observed, especially for CH-GTE.
34740680	1	6	dep	extracts	271:278	arg1	PPE					299:301	PPE	299:301	PPE	299:301	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	6	dep	extracts	271:278	arg1	extracts					271:278	different water-soluble polyphenol extracts	236:278	different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE))	236:341	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	6	dep	extracts	271:278	arg1	tea					332:334	green tea	326:334	green tea (GTE)	326:340	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	6	dep	extracts	271:278	arg1	peel					293:296	pomegranate peel	281:296	pomegranate peel (PPE)	281:302	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	6	dep	extracts	271:278	arg1	seed					311:314	seed	311:314	seed	311:314	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	6	dep	extracts	271:278	arg1	GSE					317:319	GSE	317:319	GSE	317:319	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	6	dep	extracts	271:278	arg1	GTE					337:339	GTE	337:339	GTE	337:339	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	4	7	theme	volatile	822:829	arg1	TVB-N					847:851	TVB-N	847:851	TVB-N	847:851	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	4	7	theme	volatile	822:829	arg1	nitrogen					837:844	total volatile basic nitrogen	816:844	total volatile basic nitrogen (TVB-N)	816:852	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	7	8	theme	lowest	1452:1457	arg1	values					1459:1464	the lowest values	1448:1464	the lowest values of TVB-N, TBARS, K-value and water loss	1448:1504	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	1	9	theme	different	236:244	arg1	extracts					271:278	different water-soluble polyphenol extracts	236:278	different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE))	236:341	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	9	theme	different	236:244	arg1	peel					293:296	pomegranate peel	281:296	pomegranate peel (PPE)	281:302	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	9	theme	different	236:244	arg1	tea					332:334	green tea	326:334	green tea (GTE)	326:340	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	0	10	theme	physical	100:107	arg1	state					109:113	physical state	100:113	physical state	100:113	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	3	11	theme	protective	652:661	arg1	coatings					663:670	protective coatings	652:670	protective coatings	652:670	As suggested by microbial enumeration and high-throughput sequencing, protective coatings were conductive to inhibit bacteria growth, especially spoilage bacteria of Pseudomonas.
34740680	1	12	theme	quality	378:384	arg1	retention					386:394	quality retention	378:394	quality retention	378:394	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	13	theme	water-soluble	246:258	arg1	extracts					271:278	different water-soluble polyphenol extracts	236:278	different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE))	236:341	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	13	theme	water-soluble	246:258	arg1	peel					293:296	pomegranate peel	281:296	pomegranate peel (PPE)	281:302	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	13	theme	water-soluble	246:258	arg1	tea					332:334	green tea	326:334	green tea (GTE)	326:340	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	7	14	theme	TBARS	1476:1480	arg1	values					1519:1524	highest values	1511:1524	highest values of shear force and sensory preference among groups	1511:1575	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	7	14	theme	TBARS	1476:1480	arg1	values					1459:1464	the lowest values	1448:1464	the lowest values of TVB-N, TBARS, K-value and water loss	1448:1504	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	1	15	theme	polyphenol	260:269	arg1	extracts					271:278	different water-soluble polyphenol extracts	236:278	different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE))	236:341	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	15	theme	polyphenol	260:269	arg1	peel					293:296	pomegranate peel	281:296	pomegranate peel (PPE)	281:302	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	15	theme	polyphenol	260:269	arg1	tea					332:334	green tea	326:334	green tea (GTE)	326:340	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	3	16	theme	bacteria	699:706	arg1	growth					708:713	bacteria growth	699:713	bacteria growth	699:713	As suggested by microbial enumeration and high-throughput sequencing, protective coatings were conductive to inhibit bacteria growth, especially spoilage bacteria of Pseudomonas.
34740680	5	17	dep	fillets	1066:1072	arg1	quality					1090:1096	a better edible quality	1074:1096	fillets a better edible quality	1066:1096	In addition, coating also slowed down the deterioration of physical properties of color, texture and water holding capacity in fillets, giving fillets a better edible quality.
34740680	7	18	theme	highest	1511:1517	arg1	values					1519:1524	highest values	1511:1524	highest values of shear force and sensory preference among groups	1511:1575	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	0	19	theme	state	109:113	arg1	slices					178:183	sensory, physical state, microbiota composition and quality of refrigerated grass carp slices	91:183	sensory, physical state, microbiota composition and quality of refrigerated grass carp slices	91:183	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	1	20	theme	green	326:330	arg1	extracts					271:278	different water-soluble polyphenol extracts	236:278	different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE))	236:341	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	20	theme	green	326:330	arg1	GTE					337:339	GTE	337:339	GTE	337:339	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	20	theme	green	326:330	arg1	tea					332:334	green tea	326:334	green tea (GTE)	326:340	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	6	21	theme	antibacterial	1263:1275	arg1	effect					1277:1282	a relatively good synergistic antibacterial effect	1233:1282	a relatively good synergistic antibacterial effect between chitosan and extracts	1233:1312	By contrast, the fillets treated by composite coatings had better quality during storage when compared to chitosan coating alone, and a relatively good synergistic antibacterial effect between chitosan and extracts was also observed, especially for CH-GTE.
34740680	7	22	theme	loss	1501:1504	arg1	values					1519:1524	highest values	1511:1524	highest values of shear force and sensory preference among groups	1511:1575	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	7	22	theme	loss	1501:1504	arg1	values					1459:1464	the lowest values	1448:1464	the lowest values of TVB-N, TBARS, K-value and water loss	1448:1504	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	5	23	theme	capacity	1038:1045	arg1	properties					991:1000	physical properties	982:1000	physical properties of color, texture and water holding capacity	982:1045	In addition, coating also slowed down the deterioration of physical properties of color, texture and water holding capacity in fillets, giving fillets a better edible quality.
34740680	4	24	theme	total	816:820	arg1	TVB-N					847:851	TVB-N	847:851	TVB-N	847:851	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	4	24	theme	total	816:820	arg1	nitrogen					837:844	total volatile basic nitrogen	816:844	total volatile basic nitrogen (TVB-N)	816:852	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	7	25	theme	shear	1529:1533	arg1	force					1535:1539	shear force	1529:1539	shear force	1529:1539	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	5	26	theme	water	1024:1028	arg1	capacity					1038:1045	water holding capacity	1024:1045	water holding capacity	1024:1045	In addition, coating also slowed down the deterioration of physical properties of color, texture and water holding capacity in fillets, giving fillets a better edible quality.
34740680	0	27	theme	Vacuum	0:5	arg1	impregnation					7:18	Vacuum impregnation	0:18	Vacuum impregnation of chitosan coating	0:38	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	6	28	theme	synergistic	1251:1261	arg1	effect					1277:1282	a relatively good synergistic antibacterial effect	1233:1282	a relatively good synergistic antibacterial effect between chitosan and extracts	1233:1312	By contrast, the fillets treated by composite coatings had better quality during storage when compared to chitosan coating alone, and a relatively good synergistic antibacterial effect between chitosan and extracts was also observed, especially for CH-GTE.
34740680	6	29	theme	better	1158:1163	arg1	quality					1165:1171	better quality	1158:1171	better quality	1158:1171	By contrast, the fillets treated by composite coatings had better quality during storage when compared to chitosan coating alone, and a relatively good synergistic antibacterial effect between chitosan and extracts was also observed, especially for CH-GTE.
34740680	1	30	theme	refrigerated	414:425	arg1	fillets					438:444	refrigerated grass carp fillets	414:444	refrigerated grass carp fillets	414:444	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	7	31	theme	preference	1553:1562	arg1	values					1519:1524	highest values	1511:1524	highest values of shear force and sensory preference among groups	1511:1575	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	7	31	theme	preference	1553:1562	arg1	values					1459:1464	the lowest values	1448:1464	the lowest values of TVB-N, TBARS, K-value and water loss	1448:1504	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	5	32	theme	color	1005:1009	arg1	properties					991:1000	physical properties	982:1000	physical properties of color, texture and water holding capacity	982:1045	In addition, coating also slowed down the deterioration of physical properties of color, texture and water holding capacity in fillets, giving fillets a better edible quality.
34740680	0	33	theme	chitosan	23:30	arg1	impregnation					7:18	Vacuum impregnation	0:18	Vacuum impregnation of chitosan coating	0:38	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	3	34	theme	spoilage	727:734	arg1	bacteria					736:743	spoilage bacteria	727:743	spoilage bacteria of Pseudomonas	727:758	As suggested by microbial enumeration and high-throughput sequencing, protective coatings were conductive to inhibit bacteria growth, especially spoilage bacteria of Pseudomonas.
34740680	0	35	theme	composition	127:137	arg1	slices					178:183	sensory, physical state, microbiota composition and quality of refrigerated grass carp slices	91:183	sensory, physical state, microbiota composition and quality of refrigerated grass carp slices	91:183	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	1	36	theme	grass	427:431	arg1	fillets					438:444	refrigerated grass carp fillets	414:444	refrigerated grass carp fillets	414:444	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	37	theme	pomegranate	281:291	arg1	PPE					299:301	PPE	299:301	PPE	299:301	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	37	theme	pomegranate	281:291	arg1	extracts					271:278	different water-soluble polyphenol extracts	236:278	different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE))	236:341	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	37	theme	pomegranate	281:291	arg1	peel					293:296	pomegranate peel	281:296	pomegranate peel (PPE)	281:302	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	0	38	theme	microbiota	116:125	arg1	composition					127:137	microbiota composition	116:137	microbiota composition	116:137	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	4	39	from	levels	876:881	arg1	groups					894:899	coating groups	886:899	coating groups	886:899	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	5	40	theme	holding	1030:1036	arg1	capacity					1038:1045	water holding capacity	1024:1045	water holding capacity	1024:1045	In addition, coating also slowed down the deterioration of physical properties of color, texture and water holding capacity in fillets, giving fillets a better edible quality.
34740680	6	41	contain	had	1154:1156	arg1	fillets					1116:1122	the fillets	1112:1122	the fillets treated by composite coatings	1112:1152	By contrast, the fillets treated by composite coatings had better quality during storage when compared to chitosan coating alone, and a relatively good synergistic antibacterial effect between chitosan and extracts was also observed, especially for CH-GTE.
34740680	6	41	contain	had	1154:1156	arg2	quality					1165:1171	better quality	1158:1171	better quality	1158:1171	By contrast, the fillets treated by composite coatings had better quality during storage when compared to chitosan coating alone, and a relatively good synergistic antibacterial effect between chitosan and extracts was also observed, especially for CH-GTE.
34740680	0	42	theme	quality	143:149	arg1	slices					178:183	sensory, physical state, microbiota composition and quality of refrigerated grass carp slices	91:183	sensory, physical state, microbiota composition and quality of refrigerated grass carp slices	91:183	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	3	43	theme	microbial	598:606	arg1	enumeration					608:618	microbial enumeration	598:618	microbial enumeration	598:618	As suggested by microbial enumeration and high-throughput sequencing, protective coatings were conductive to inhibit bacteria growth, especially spoilage bacteria of Pseudomonas.
34740680	6	44	theme	chitosan	1205:1212	arg1	coating					1214:1220	chitosan coating	1205:1220	chitosan coating alone	1205:1226	By contrast, the fillets treated by composite coatings had better quality during storage when compared to chitosan coating alone, and a relatively good synergistic antibacterial effect between chitosan and extracts was also observed, especially for CH-GTE.
34740680	4	45	contain	had	866:868	arg2	levels					876:881	lower levels	870:881	lower levels in coating groups	870:899	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	4	45	contain	had	866:868	arg1	indicator					778:786	the indicator	774:786	the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value	774:864	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	4	45	contain	had	866:868	arg2	result					766:771	a result	764:771	a result	764:771	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	0	46	theme	coating	32:38	arg1	chitosan					23:30	chitosan coating	23:38	chitosan coating	23:38	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	3	47	theme	Pseudomonas	748:758	arg1	bacteria					736:743	spoilage bacteria	727:743	spoilage bacteria of Pseudomonas	727:758	As suggested by microbial enumeration and high-throughput sequencing, protective coatings were conductive to inhibit bacteria growth, especially spoilage bacteria of Pseudomonas.
34740680	2	48	theme	quality	475:481	arg1	degradation					483:493	the quality degradation	471:493	the quality degradation of carp fillets	471:509	Generally, the quality degradation of carp fillets was remarkably alleviated using coatings when compared to the control.
34740680	0	49	from	extracts	79:86	arg1	slices					178:183	sensory, physical state, microbiota composition and quality of refrigerated grass carp slices	91:183	sensory, physical state, microbiota composition and quality of refrigerated grass carp slices	91:183	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	7	50	theme	best	1369:1372	arg1	performance					1374:1384	the best performance	1365:1384	the best performance to inhibit quality deterioration	1365:1417	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	1	51	theme	carp	433:436	arg1	fillets					438:444	refrigerated grass carp fillets	414:444	refrigerated grass carp fillets	414:444	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	52	theme	chitosan	209:216	arg1	effects					198:204	the effects	194:204	the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets	194:444	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	0	53	theme	water-soluble	54:66	arg1	extracts					79:86	water-soluble polyphenol extracts	54:86	water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices	54:183	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	4	54	theme	coating	886:892	arg1	groups					894:899	coating groups	886:899	coating groups	886:899	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	0	55	theme	refrigerated	154:165	arg1	carp					173:176	refrigerated grass carp	154:176	refrigerated grass carp	154:176	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	5	56	theme	texture	1012:1018	arg1	properties					991:1000	physical properties	982:1000	physical properties of color, texture and water holding capacity	982:1045	In addition, coating also slowed down the deterioration of physical properties of color, texture and water holding capacity in fillets, giving fillets a better edible quality.
34740680	6	57	theme	composite	1135:1143	arg1	coatings					1145:1152	composite coatings	1135:1152	composite coatings	1135:1152	By contrast, the fillets treated by composite coatings had better quality during storage when compared to chitosan coating alone, and a relatively good synergistic antibacterial effect between chitosan and extracts was also observed, especially for CH-GTE.
34740680	1	58	theme	fillets	438:444	arg1	retention					386:394	quality retention	378:394	quality retention	378:394	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	58	theme	fillets	438:444	arg1	microflora					400:409	microflora	400:409	microflora	400:409	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	4	59	theme	lower	870:874	arg1	result					766:771	a result	764:771	a result	764:771	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	4	59	theme	lower	870:874	arg1	levels					876:881	lower levels	870:881	lower levels in coating groups	870:899	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	5	60	theme	better	1076:1081	arg1	quality					1090:1096	a better edible quality	1074:1096	fillets a better edible quality	1066:1096	In addition, coating also slowed down the deterioration of physical properties of color, texture and water holding capacity in fillets, giving fillets a better edible quality.
34740680	2	61	theme	carp	498:501	arg1	fillets					503:509	carp fillets	498:509	carp fillets	498:509	Generally, the quality degradation of carp fillets was remarkably alleviated using coatings when compared to the control.
34740680	3	62	theme	high-throughput	624:638	arg1	sequencing					640:649	high-throughput sequencing	624:649	high-throughput sequencing	624:649	As suggested by microbial enumeration and high-throughput sequencing, protective coatings were conductive to inhibit bacteria growth, especially spoilage bacteria of Pseudomonas.
34740680	4	63	theme	related	788:794	arg1	indicator					778:786	the indicator	774:786	the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value	774:864	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	1	64	dep	retention	386:394	arg1	the					374:376	the	374:376	the	374:376	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	5	65	theme	edible	1083:1088	arg1	quality					1090:1096	a better edible quality	1074:1096	fillets a better edible quality	1066:1096	In addition, coating also slowed down the deterioration of physical properties of color, texture and water holding capacity in fillets, giving fillets a better edible quality.
34740680	0	66	theme	carp	173:176	arg1	sensory					91:97	sensory	91:97	sensory	91:97	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	0	66	theme	carp	173:176	arg1	state					109:113	physical state	100:113	physical state	100:113	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	0	66	theme	carp	173:176	arg1	composition					127:137	microbiota composition	116:137	microbiota composition	116:137	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	0	66	theme	carp	173:176	arg1	quality					143:149	quality	143:149	quality of refrigerated grass carp	143:176	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	1	67	theme	vacuum	351:356	arg1	impregnation					358:369	vacuum impregnation	351:369	vacuum impregnation	351:369	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	68	from	effects	198:204	arg1	retention					386:394	quality retention	378:394	quality retention	378:394	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	1	68	from	effects	198:204	arg1	microflora					400:409	microflora	400:409	microflora	400:409	Herein, the effects of chitosan (CH) coating with different water-soluble polyphenol extracts (pomegranate peel (PPE), grape seed (GSE) and green tea (GTE)) through vacuum impregnation on the quality retention and microflora of refrigerated grass carp fillets were studied.
34740680	7	69	theme	quality	1397:1403	arg1	deterioration					1405:1417	quality deterioration	1397:1417	quality deterioration	1397:1417	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	0	70	theme	grass	167:171	arg1	carp					173:176	refrigerated grass carp	154:176	refrigerated grass carp	154:176	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	5	71	theme	physical	982:989	arg1	properties					991:1000	physical properties	982:1000	physical properties of color, texture and water holding capacity	982:1045	In addition, coating also slowed down the deterioration of physical properties of color, texture and water holding capacity in fillets, giving fillets a better edible quality.
34740680	7	72	theme	sensory	1545:1551	arg1	preference					1553:1562	sensory preference	1545:1562	sensory preference	1545:1562	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	7	73	theme	water	1495:1499	arg1	loss					1501:1504	water loss	1495:1504	water loss	1495:1504	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	7	74	dep	performance	1374:1384	arg1	inhibit					1389:1395	inhibit	1389:1395	to inhibit quality deterioration	1386:1417	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	5	75	theme	properties	991:1000	arg1	deterioration					965:977	the deterioration	961:977	the deterioration of physical properties of color, texture and water holding capacity in fillets	961:1056	In addition, coating also slowed down the deterioration of physical properties of color, texture and water holding capacity in fillets, giving fillets a better edible quality.
34740680	7	76	theme	TVB-N	1469:1473	arg1	values					1519:1524	highest values	1511:1524	highest values of shear force and sensory preference among groups	1511:1575	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	7	76	theme	TVB-N	1469:1473	arg1	values					1459:1464	the lowest values	1448:1464	the lowest values of TVB-N, TBARS, K-value and water loss	1448:1504	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	4	77	theme	K	858:858	arg1	value					860:864	K value	858:864	K value	858:864	As a result, the indicator related to bacteria such as total volatile basic nitrogen (TVB-N) and K value had lower levels in coating groups than that in control.
34740680	0	78	theme	polyphenol	68:77	arg1	extracts					79:86	water-soluble polyphenol extracts	54:86	water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices	54:183	Vacuum impregnation of chitosan coating combined with water-soluble polyphenol extracts on sensory, physical state, microbiota composition and quality of refrigerated grass carp slices.
34740680	7	79	theme	K-value	1483:1489	arg1	values					1519:1524	highest values	1511:1524	highest values of shear force and sensory preference among groups	1511:1575	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34740680	7	79	theme	K-value	1483:1489	arg1	values					1459:1464	the lowest values	1448:1464	the lowest values of TVB-N, TBARS, K-value and water loss	1448:1504	Overall, the best performance to inhibit quality deterioration was recorded in CH-GTE, with the lowest values of TVB-N, TBARS, K-value and water loss, and highest values of shear force and sensory preference among groups.
34296452	14	0	theme	nerve	2621:2625	arg1	injury					2627:2632	nerve injury	2621:2632	nerve injury	2621:2632	For the first time, our research demonstrates that CNTs-CaP/CS-AZ91D likely provide a suitable environment for neuron growth, suggesting these AZ91D-based composites as potential implantable biomaterials for the treatment of nerve injury.
34296452	13	1	theme	CaP/CS-AZ91D	2382:2393	arg1	performance					2367:2377	the performance	2363:2377	the performance of CaP/CS-AZ91D	2363:2393	Notably, the addition of CNTs improves the performance of CaP/CS-AZ91D.
34296452	11	2	theme	calcium	2014:2020	arg1	CaP					2033:2035	CaP	2033:2035	CaP	2033:2035	SIGNIFICANCE: AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated and their immersion extracts were prepared using modified simulated body fluid in this study.
34296452	11	2	theme	calcium	2014:2020	arg1	phosphate					2022:2030	calcium phosphate	2014:2030	calcium phosphate (CaP)/chitosan (CS)	2014:2050	SIGNIFICANCE: AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated and their immersion extracts were prepared using modified simulated body fluid in this study.
34296452	7	3	theme	neuron	1380:1385	arg1	growth					1387:1392	DRG neuron growth	1376:1392	DRG neuron growth	1376:1392	Overall, the extracts from these AZ91D-based composites might promote DRG neuron growth via activating ERK signalling pathway.
34296452	12	4	theme	signalling	2304:2313	arg1	pathway					2315:2321	ERK signalling pathway	2300:2321	ERK signalling pathway	2300:2321	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	3	5	theme	simulated	527:535	arg1	fluid					542:546	modified simulated body fluid	518:546	modified simulated body fluid (m-SBF) for 0, 2, 8, 16, 24, 34, 44, 60, or 90 days	518:598	To evaluate the bioactivity of these AZ91D-based composites, the extracts were prepared by immersing samples in modified simulated body fluid (m-SBF) for 0, 2, 8, 16, 24, 34, 44, 60, or 90 days.
34296452	3	5	theme	simulated	527:535	arg1	m-SBF					549:553	m-SBF	549:553	m-SBF	549:553	To evaluate the bioactivity of these AZ91D-based composites, the extracts were prepared by immersing samples in modified simulated body fluid (m-SBF) for 0, 2, 8, 16, 24, 34, 44, 60, or 90 days.
34296452	10	6	theme	implantable	1876:1886	arg1	biomaterial					1888:1898	a potential implantable biomaterial	1864:1898	a potential implantable biomaterial for the treatment of nerve injury	1864:1932	These findings demonstrate that CNTs-CaP/CS-AZ91D likely provide a more suitable environment for neuron growth, which suggests a potential implantable biomaterial for the treatment of nerve injury.
34296452	2	7	theme	magnesium	279:287	arg1	alloy					289:293	AZ91D magnesium alloy	273:293	AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS)	273:374	AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated in this study.
34296452	4	8	theme	root	766:769	arg1	neurons					785:791	dorsal root ganglia (DRG) neurons	759:791	dorsal root ganglia (DRG) neurons	759:791	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	10	9	theme	nerve	1921:1925	arg1	injury					1927:1932	nerve injury	1921:1932	nerve injury	1921:1932	These findings demonstrate that CNTs-CaP/CS-AZ91D likely provide a more suitable environment for neuron growth, which suggests a potential implantable biomaterial for the treatment of nerve injury.
34296452	1	10	theme	biodegradable	198:210	arg1	alloys					248:253	its alloys	244:253	its alloys in neuron repair	244:270	Increasing attention has been paid on the application of biodegradable materials such as magnesium and its alloys in neuron repair.
34296452	1	10	theme	biodegradable	198:210	arg1	materials					212:220	biodegradable materials	198:220	biodegradable materials such as magnesium and its alloys in neuron repair	198:270	Increasing attention has been paid on the application of biodegradable materials such as magnesium and its alloys in neuron repair.
34296452	1	10	theme	biodegradable	198:210	arg1	magnesium					230:238	magnesium	230:238	magnesium	230:238	Increasing attention has been paid on the application of biodegradable materials such as magnesium and its alloys in neuron repair.
34296452	9	11	theme	magnesium	1615:1623	arg1	resistance					1635:1644	magnesium corrosion resistance	1615:1644	magnesium corrosion resistance	1615:1644	Assessment of ion elements showed that the addition of CNTs coating enhanced magnesium corrosion resistance and reduced the deposition of calcium and phosphorus on the surface of CaP/CS-AZ91D alloy.
34296452	2	12	theme	carbon	307:312	arg1	nanotubes					314:322	carbon nanotubes	307:322	carbon nanotubes (CNTs)	307:329	AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated in this study.
34296452	2	12	theme	carbon	307:312	arg1	CNTs					325:328	CNTs	325:328	CNTs	325:328	AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated in this study.
34296452	4	13	theme	phosphorylated	835:848	arg1	kinase					865:870	phosphorylated focal adhesion kinase	835:870	phosphorylated focal adhesion kinase (p-FAK)	835:878	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	4	13	theme	phosphorylated	835:848	arg1	p-FAK					873:877	p-FAK	873:877	p-FAK	873:877	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	6	14	theme	DRG	1124:1126	arg1	neurons					1128:1134	DRG neurons	1124:1134	DRG neurons	1124:1134	ERK signalling was activated in DRG neurons after treating with either CNTs-CaP/CS-AZ91D or CaP/CS-AZ91D extracts, and its inhibition with U0126 counteracted the beneficial effects of these extracts on DRG neuron.
34296452	12	15	from	CNTs-CaP/CS	2180:2190	arg1	extracts					2166:2173	Both extracts	2161:2173	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy	2161:2230	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	12	16	theme	neuron	2271:2276	arg1	growth					2278:2283	rat dorsal root ganglia (DRG) neuron growth	2241:2283	rat dorsal root ganglia (DRG) neuron growth	2241:2283	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	4	17	theme	Immunofluorescence	601:618	arg1	staining					620:627	Immunofluorescence staining	601:627	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1)	601:667	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	14	18	theme	first	2404:2408	arg1	time					2410:2413	the first time	2400:2413	the first time	2400:2413	For the first time, our research demonstrates that CNTs-CaP/CS-AZ91D likely provide a suitable environment for neuron growth, suggesting these AZ91D-based composites as potential implantable biomaterials for the treatment of nerve injury.
34296452	11	19	theme	phosphate	2022:2030	arg1	CS					2048:2049	CS	2048:2049	CS	2048:2049	SIGNIFICANCE: AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated and their immersion extracts were prepared using modified simulated body fluid in this study.
34296452	11	19	theme	phosphate	2022:2030	arg1	/chitosan					2037:2045	calcium phosphate (CaP)/chitosan	2014:2045	calcium phosphate (CaP)/chitosan (CS)	2014:2050	SIGNIFICANCE: AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated and their immersion extracts were prepared using modified simulated body fluid in this study.
34296452	12	20	theme	dorsal	2245:2250	arg1	ganglia					2257:2263	rat dorsal root ganglia	2241:2263	rat dorsal root ganglia (DRG) neuron growth	2241:2283	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	12	20	theme	dorsal	2245:2250	arg1	DRG					2266:2268	DRG	2266:2268	DRG	2266:2268	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	9	21	theme	calcium	1676:1682	arg1	deposition					1662:1671	the deposition	1658:1671	the deposition of calcium and phosphorus on the surface of CaP/CS-AZ91D alloy	1658:1734	Assessment of ion elements showed that the addition of CNTs coating enhanced magnesium corrosion resistance and reduced the deposition of calcium and phosphorus on the surface of CaP/CS-AZ91D alloy.
34296452	12	22	theme	ganglia	2257:2263	arg1	growth					2278:2283	rat dorsal root ganglia (DRG) neuron growth	2241:2283	rat dorsal root ganglia (DRG) neuron growth	2241:2283	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	0	23	theme	root	75:78	arg1	ganglia					80:86	rat dorsal root ganglia	64:86	rat dorsal root ganglia neuron growth	64:100	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway.
34296452	5	24	theme	nerve	1020:1024	arg1	NGF					1041:1043	NGF	1041:1043	NGF	1041:1043	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	5	24	theme	nerve	1020:1024	arg1	factor					1033:1038	nerve growth factor	1020:1038	nerve growth factor (NGF)	1020:1044	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	14	25	theme	AZ91D-based	2539:2549	arg1	composites					2551:2560	these AZ91D-based composites	2533:2560	these AZ91D-based composites	2533:2560	For the first time, our research demonstrates that CNTs-CaP/CS-AZ91D likely provide a suitable environment for neuron growth, suggesting these AZ91D-based composites as potential implantable biomaterials for the treatment of nerve injury.
34296452	14	25	theme	AZ91D-based	2539:2549	arg1	biomaterials					2587:2598	potential implantable biomaterials	2565:2598	potential implantable biomaterials for the treatment of nerve injury	2565:2632	For the first time, our research demonstrates that CNTs-CaP/CS-AZ91D likely provide a suitable environment for neuron growth, suggesting these AZ91D-based composites as potential implantable biomaterials for the treatment of nerve injury.
34296452	4	26	theme	growth	884:889	arg1	GAP-43					914:919	GAP-43	914:919	GAP-43	914:919	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	4	26	theme	growth	884:889	arg1	protein-43					902:911	growth associated protein-43	884:911	growth associated protein-43 (GAP-43)	884:920	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	12	27	theme	magnesium	2216:2224	arg1	alloy					2226:2230	CaP/CS-coated AZ91D magnesium alloy	2196:2230	CaP/CS-coated AZ91D magnesium alloy	2196:2230	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	0	28	theme	neuron	88:93	arg1	growth					95:100	rat dorsal root ganglia neuron growth	64:100	rat dorsal root ganglia neuron growth	64:100	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway.
34296452	14	29	theme	neuron	2507:2512	arg1	growth					2514:2519	neuron growth	2507:2519	neuron growth	2507:2519	For the first time, our research demonstrates that CNTs-CaP/CS-AZ91D likely provide a suitable environment for neuron growth, suggesting these AZ91D-based composites as potential implantable biomaterials for the treatment of nerve injury.
34296452	4	30	theme	adhesion	856:863	arg1	kinase					865:870	phosphorylated focal adhesion kinase	835:870	phosphorylated focal adhesion kinase (p-FAK)	835:878	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	4	30	theme	adhesion	856:863	arg1	p-FAK					873:877	p-FAK	873:877	p-FAK	873:877	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	0	31	theme	ERK	117:119	arg1	pathway					132:138	ERK signalling pathway	117:138	ERK signalling pathway	117:138	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway.
34296452	5	32	theme	factors	1002:1008	arg1	expression					959:968	the expression	955:968	the expression	955:968	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	5	32	theme	factors	1002:1008	arg1	release					978:984	the release	974:984	the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF)	974:1089	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	11	33	theme	simulated	2125:2133	arg1	fluid					2140:2144	modified simulated body fluid	2116:2144	modified simulated body fluid	2116:2144	SIGNIFICANCE: AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated and their immersion extracts were prepared using modified simulated body fluid in this study.
34296452	9	34	theme	alloy	1730:1734	arg1	surface					1706:1712	the surface	1702:1712	the surface of CaP/CS-AZ91D alloy	1702:1734	Assessment of ion elements showed that the addition of CNTs coating enhanced magnesium corrosion resistance and reduced the deposition of calcium and phosphorus on the surface of CaP/CS-AZ91D alloy.
34296452	12	35	theme	CaP/CS-coated	2196:2208	arg1	alloy					2226:2230	CaP/CS-coated AZ91D magnesium alloy	2196:2230	CaP/CS-coated AZ91D magnesium alloy	2196:2230	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	0	36	theme	ganglia	80:86	arg1	growth					95:100	rat dorsal root ganglia neuron growth	64:100	rat dorsal root ganglia neuron growth	64:100	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway.
34296452	4	37	theme	class	642:646	arg1	TUJ1					663:666	TUJ1	663:666	TUJ1	663:666	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	4	37	theme	class	642:646	arg1	β-tubulin					652:660	neuronal class III β-tubulin	633:660	neuronal class III β-tubulin (TUJ1)	633:667	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	0	38	theme	CNTs-CaP/chitosan-coated	0:23	arg1	extract					47:53	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract	0:53	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract	0:53	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway.
34296452	5	39	theme	neurotrophic	1064:1075	arg1	factor					1077:1082	brain-derived neurotrophic factor	1050:1082	brain-derived neurotrophic factor (BDNF)	1050:1089	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	5	39	theme	neurotrophic	1064:1075	arg1	BDNF					1085:1088	BDNF	1085:1088	BDNF	1085:1088	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	11	40	theme	immersion	2077:2085	arg1	extracts					2087:2094	their immersion extracts	2071:2094	their immersion extracts	2071:2094	SIGNIFICANCE: AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated and their immersion extracts were prepared using modified simulated body fluid in this study.
34296452	0	41	theme	magnesium	31:39	arg1	extract					47:53	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract	0:53	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract	0:53	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway.
34296452	14	42	theme	suitable	2482:2489	arg1	environment					2491:2501	a suitable environment	2480:2501	a suitable environment for neuron growth	2480:2519	For the first time, our research demonstrates that CNTs-CaP/CS-AZ91D likely provide a suitable environment for neuron growth, suggesting these AZ91D-based composites as potential implantable biomaterials for the treatment of nerve injury.
34296452	13	43	theme	CNTs	2349:2352	arg1	addition					2337:2344	the addition	2333:2344	the addition of CNTs	2333:2352	Notably, the addition of CNTs improves the performance of CaP/CS-AZ91D.
34296452	4	44	theme	protein-43	902:911	arg1	expression					821:830	increased expression	811:830	increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43)	811:920	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	11	45	theme	body	2135:2138	arg1	fluid					2140:2144	modified simulated body fluid	2116:2144	modified simulated body fluid	2116:2144	SIGNIFICANCE: AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated and their immersion extracts were prepared using modified simulated body fluid in this study.
34296452	8	46	theme	promoting	1485:1493	arg1	effect					1495:1500	a better promoting effect	1476:1500	a better promoting effect on neuron growth than CaP/CS-AZ91D	1476:1535	Notably, CNTs-CaP/CS-AZ91D extracts showed a better promoting effect on neuron growth than CaP/CS-AZ91D.
34296452	4	47	theme	axon	741:744	arg1	outgrowth					746:754	axon outgrowth	741:754	axon outgrowth of dorsal root ganglia (DRG) neurons	741:791	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	2	48	theme	phosphate	346:354	arg1	CS					372:373	CS	372:373	CS	372:373	AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated in this study.
34296452	2	48	theme	phosphate	346:354	arg1	/chitosan					361:369	calcium phosphate (CaP)/chitosan	338:369	calcium phosphate (CaP)/chitosan (CS)	338:374	AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated in this study.
34296452	0	49	theme	rat	64:66	arg1	ganglia					80:86	rat dorsal root ganglia	64:86	rat dorsal root ganglia neuron growth	64:100	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway.
34296452	7	50	theme	signalling	1413:1422	arg1	pathway					1424:1430	ERK signalling pathway	1409:1430	ERK signalling pathway	1409:1430	Overall, the extracts from these AZ91D-based composites might promote DRG neuron growth via activating ERK signalling pathway.
34296452	10	51	theme	neuron	1834:1839	arg1	growth					1841:1846	neuron growth	1834:1846	neuron growth	1834:1846	These findings demonstrate that CNTs-CaP/CS-AZ91D likely provide a more suitable environment for neuron growth, which suggests a potential implantable biomaterial for the treatment of nerve injury.
34296452	3	52	theme	composites	455:464	arg1	bioactivity					422:432	the bioactivity	418:432	the bioactivity of these AZ91D-based composites	418:464	To evaluate the bioactivity of these AZ91D-based composites, the extracts were prepared by immersing samples in modified simulated body fluid (m-SBF) for 0, 2, 8, 16, 24, 34, 44, 60, or 90 days.
34296452	11	53	theme	magnesium	1955:1963	arg1	alloy					1965:1969	AZ91D magnesium alloy	1949:1969	AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS)	1949:2050	SIGNIFICANCE: AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated and their immersion extracts were prepared using modified simulated body fluid in this study.
34296452	9	54	theme	elements	1556:1563	arg1	Assessment					1538:1547	Assessment	1538:1547	Assessment of ion elements	1538:1563	Assessment of ion elements showed that the addition of CNTs coating enhanced magnesium corrosion resistance and reduced the deposition of calcium and phosphorus on the surface of CaP/CS-AZ91D alloy.
34296452	14	55	theme	injury	2627:2632	arg1	treatment					2608:2616	the treatment	2604:2616	the treatment of nerve injury	2604:2632	For the first time, our research demonstrates that CNTs-CaP/CS-AZ91D likely provide a suitable environment for neuron growth, suggesting these AZ91D-based composites as potential implantable biomaterials for the treatment of nerve injury.
34296452	9	56	theme	phosphorus	1688:1697	arg1	deposition					1662:1671	the deposition	1658:1671	the deposition of calcium and phosphorus on the surface of CaP/CS-AZ91D alloy	1658:1734	Assessment of ion elements showed that the addition of CNTs coating enhanced magnesium corrosion resistance and reduced the deposition of calcium and phosphorus on the surface of CaP/CS-AZ91D alloy.
34296452	6	57	theme	CaP/CS-AZ91D	1184:1195	arg1	extracts					1197:1204	either CNTs-CaP/CS-AZ91D or CaP/CS-AZ91D extracts	1156:1204	either CNTs-CaP/CS-AZ91D or CaP/CS-AZ91D extracts	1156:1204	ERK signalling was activated in DRG neurons after treating with either CNTs-CaP/CS-AZ91D or CaP/CS-AZ91D extracts, and its inhibition with U0126 counteracted the beneficial effects of these extracts on DRG neuron.
34296452	1	58	theme	neuron	258:263	arg1	repair					265:270	neuron repair	258:270	neuron repair	258:270	Increasing attention has been paid on the application of biodegradable materials such as magnesium and its alloys in neuron repair.
34296452	7	59	theme	DRG	1376:1378	arg1	growth					1387:1392	DRG neuron growth	1376:1392	DRG neuron growth	1376:1392	Overall, the extracts from these AZ91D-based composites might promote DRG neuron growth via activating ERK signalling pathway.
34296452	4	60	theme	ganglia	771:777	arg1	neurons					785:791	dorsal root ganglia (DRG) neurons	759:791	dorsal root ganglia (DRG) neurons	759:791	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	6	61	theme	CNTs-CaP/CS-AZ91D	1163:1179	arg1	extracts					1197:1204	either CNTs-CaP/CS-AZ91D or CaP/CS-AZ91D extracts	1156:1204	either CNTs-CaP/CS-AZ91D or CaP/CS-AZ91D extracts	1156:1204	ERK signalling was activated in DRG neurons after treating with either CNTs-CaP/CS-AZ91D or CaP/CS-AZ91D extracts, and its inhibition with U0126 counteracted the beneficial effects of these extracts on DRG neuron.
34296452	3	62	theme	modified	518:525	arg1	fluid					542:546	modified simulated body fluid	518:546	modified simulated body fluid (m-SBF) for 0, 2, 8, 16, 24, 34, 44, 60, or 90 days	518:598	To evaluate the bioactivity of these AZ91D-based composites, the extracts were prepared by immersing samples in modified simulated body fluid (m-SBF) for 0, 2, 8, 16, 24, 34, 44, 60, or 90 days.
34296452	3	62	theme	modified	518:525	arg1	m-SBF					549:553	m-SBF	549:553	m-SBF	549:553	To evaluate the bioactivity of these AZ91D-based composites, the extracts were prepared by immersing samples in modified simulated body fluid (m-SBF) for 0, 2, 8, 16, 24, 34, 44, 60, or 90 days.
34296452	4	63	theme	DRG	780:782	arg1	neurons					785:791	dorsal root ganglia (DRG) neurons	759:791	dorsal root ganglia (DRG) neurons	759:791	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	12	64	theme	ERK	2300:2302	arg1	pathway					2315:2321	ERK signalling pathway	2300:2321	ERK signalling pathway	2300:2321	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	11	65	theme	AZ91D	1949:1953	arg1	alloy					1965:1969	AZ91D magnesium alloy	1949:1969	AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS)	1949:2050	SIGNIFICANCE: AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated and their immersion extracts were prepared using modified simulated body fluid in this study.
34296452	6	66	with	inhibition	1215:1224	arg1	U0126					1231:1235	U0126	1231:1235	U0126	1231:1235	ERK signalling was activated in DRG neurons after treating with either CNTs-CaP/CS-AZ91D or CaP/CS-AZ91D extracts, and its inhibition with U0126 counteracted the beneficial effects of these extracts on DRG neuron.
34296452	7	67	theme	AZ91D-based	1339:1349	arg1	composites					1351:1360	these AZ91D-based composites	1333:1360	these AZ91D-based composites	1333:1360	Overall, the extracts from these AZ91D-based composites might promote DRG neuron growth via activating ERK signalling pathway.
34296452	9	68	theme	CNTs	1593:1596	arg1	addition					1581:1588	the addition	1577:1588	the addition of CNTs coating	1577:1604	Assessment of ion elements showed that the addition of CNTs coating enhanced magnesium corrosion resistance and reduced the deposition of calcium and phosphorus on the surface of CaP/CS-AZ91D alloy.
34296452	10	69	theme	potential	1866:1874	arg1	biomaterial					1888:1898	a potential implantable biomaterial	1864:1898	a potential implantable biomaterial for the treatment of nerve injury	1864:1932	These findings demonstrate that CNTs-CaP/CS-AZ91D likely provide a more suitable environment for neuron growth, which suggests a potential implantable biomaterial for the treatment of nerve injury.
34296452	8	70	from	effect	1495:1500	arg1	growth					1512:1517	neuron growth	1505:1517	neuron growth	1505:1517	Notably, CNTs-CaP/CS-AZ91D extracts showed a better promoting effect on neuron growth than CaP/CS-AZ91D.
34296452	7	71	from	composites	1351:1360	arg1	extracts					1319:1326	the extracts	1315:1326	the extracts from these AZ91D-based composites	1315:1360	Overall, the extracts from these AZ91D-based composites might promote DRG neuron growth via activating ERK signalling pathway.
34296452	4	72	theme	dorsal	759:764	arg1	neurons					785:791	dorsal root ganglia (DRG) neurons	759:791	dorsal root ganglia (DRG) neurons	759:791	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	3	73	theme	body	537:540	arg1	fluid					542:546	modified simulated body fluid	518:546	modified simulated body fluid (m-SBF) for 0, 2, 8, 16, 24, 34, 44, 60, or 90 days	518:598	To evaluate the bioactivity of these AZ91D-based composites, the extracts were prepared by immersing samples in modified simulated body fluid (m-SBF) for 0, 2, 8, 16, 24, 34, 44, 60, or 90 days.
34296452	3	73	theme	body	537:540	arg1	m-SBF					549:553	m-SBF	549:553	m-SBF	549:553	To evaluate the bioactivity of these AZ91D-based composites, the extracts were prepared by immersing samples in modified simulated body fluid (m-SBF) for 0, 2, 8, 16, 24, 34, 44, 60, or 90 days.
34296452	1	74	theme	materials	212:220	arg1	application					183:193	the application	179:193	the application of biodegradable materials such as magnesium and its alloys in neuron repair	179:270	Increasing attention has been paid on the application of biodegradable materials such as magnesium and its alloys in neuron repair.
34296452	4	75	theme	increased	811:819	arg1	expression					821:830	increased expression	811:830	increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43)	811:920	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	14	76	theme	implantable	2575:2585	arg1	composites					2551:2560	these AZ91D-based composites	2533:2560	these AZ91D-based composites	2533:2560	For the first time, our research demonstrates that CNTs-CaP/CS-AZ91D likely provide a suitable environment for neuron growth, suggesting these AZ91D-based composites as potential implantable biomaterials for the treatment of nerve injury.
34296452	14	76	theme	implantable	2575:2585	arg1	biomaterials					2587:2598	potential implantable biomaterials	2565:2598	potential implantable biomaterials for the treatment of nerve injury	2565:2632	For the first time, our research demonstrates that CNTs-CaP/CS-AZ91D likely provide a suitable environment for neuron growth, suggesting these AZ91D-based composites as potential implantable biomaterials for the treatment of nerve injury.
34296452	12	77	from	alloy	2226:2230	arg1	extracts					2166:2173	Both extracts	2161:2173	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy	2161:2230	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	1	78	from	alloys	248:253	arg1	repair					265:270	neuron repair	258:270	neuron repair	258:270	Increasing attention has been paid on the application of biodegradable materials such as magnesium and its alloys in neuron repair.
34296452	1	79	from	magnesium	230:238	arg1	repair					265:270	neuron repair	258:270	neuron repair	258:270	Increasing attention has been paid on the application of biodegradable materials such as magnesium and its alloys in neuron repair.
34296452	4	80	theme	neurons	785:791	arg1	outgrowth					746:754	axon outgrowth	741:754	axon outgrowth of dorsal root ganglia (DRG) neurons	741:791	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	12	81	theme	root	2252:2255	arg1	ganglia					2257:2263	rat dorsal root ganglia	2241:2263	rat dorsal root ganglia (DRG) neuron growth	2241:2283	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	12	81	theme	root	2252:2255	arg1	DRG					2266:2268	DRG	2266:2268	DRG	2266:2268	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	10	82	theme	injury	1927:1932	arg1	treatment					1908:1916	the treatment	1904:1916	the treatment of nerve injury	1904:1932	These findings demonstrate that CNTs-CaP/CS-AZ91D likely provide a more suitable environment for neuron growth, which suggests a potential implantable biomaterial for the treatment of nerve injury.
34296452	2	83	theme	AZ91D	273:277	arg1	alloy					289:293	AZ91D magnesium alloy	273:293	AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS)	273:374	AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated in this study.
34296452	1	84	theme	Increasing	141:150	arg1	attention					152:160	Increasing attention	141:160	Increasing attention	141:160	Increasing attention has been paid on the application of biodegradable materials such as magnesium and its alloys in neuron repair.
34296452	9	85	from	deposition	1662:1671	arg1	surface					1706:1712	the surface	1702:1712	the surface of CaP/CS-AZ91D alloy	1702:1734	Assessment of ion elements showed that the addition of CNTs coating enhanced magnesium corrosion resistance and reduced the deposition of calcium and phosphorus on the surface of CaP/CS-AZ91D alloy.
34296452	6	86	theme	ERK	1092:1094	arg1	signalling					1096:1105	ERK signalling	1092:1105	ERK signalling	1092:1105	ERK signalling was activated in DRG neurons after treating with either CNTs-CaP/CS-AZ91D or CaP/CS-AZ91D extracts, and its inhibition with U0126 counteracted the beneficial effects of these extracts on DRG neuron.
34296452	6	87	theme	DRG	1294:1296	arg1	neuron					1298:1303	DRG neuron	1294:1303	DRG neuron	1294:1303	ERK signalling was activated in DRG neurons after treating with either CNTs-CaP/CS-AZ91D or CaP/CS-AZ91D extracts, and its inhibition with U0126 counteracted the beneficial effects of these extracts on DRG neuron.
34296452	6	88	theme	extracts	1282:1289	arg1	effects					1265:1271	the beneficial effects	1250:1271	the beneficial effects of these extracts on DRG neuron	1250:1303	ERK signalling was activated in DRG neurons after treating with either CNTs-CaP/CS-AZ91D or CaP/CS-AZ91D extracts, and its inhibition with U0126 counteracted the beneficial effects of these extracts on DRG neuron.
34296452	5	89	theme	growth	1026:1031	arg1	NGF					1041:1043	NGF	1041:1043	NGF	1041:1043	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	5	89	theme	growth	1026:1031	arg1	factor					1033:1038	nerve growth factor	1020:1038	nerve growth factor (NGF)	1020:1044	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	9	90	theme	corrosion	1625:1633	arg1	resistance					1635:1644	magnesium corrosion resistance	1615:1644	magnesium corrosion resistance	1615:1644	Assessment of ion elements showed that the addition of CNTs coating enhanced magnesium corrosion resistance and reduced the deposition of calcium and phosphorus on the surface of CaP/CS-AZ91D alloy.
34296452	12	91	theme	rat	2241:2243	arg1	ganglia					2257:2263	rat dorsal root ganglia	2241:2263	rat dorsal root ganglia (DRG) neuron growth	2241:2283	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	12	91	theme	rat	2241:2243	arg1	DRG					2266:2268	DRG	2266:2268	DRG	2266:2268	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	11	92	theme	carbon	1983:1988	arg1	CNTs					2001:2004	CNTs	2001:2004	CNTs	2001:2004	SIGNIFICANCE: AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated and their immersion extracts were prepared using modified simulated body fluid in this study.
34296452	11	92	theme	carbon	1983:1988	arg1	nanotubes					1990:1998	carbon nanotubes	1983:1998	carbon nanotubes (CNTs)	1983:2005	SIGNIFICANCE: AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated and their immersion extracts were prepared using modified simulated body fluid in this study.
34296452	4	93	theme	focal	850:854	arg1	kinase					865:870	phosphorylated focal adhesion kinase	835:870	phosphorylated focal adhesion kinase (p-FAK)	835:878	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	4	93	theme	focal	850:854	arg1	p-FAK					873:877	p-FAK	873:877	p-FAK	873:877	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	0	94	theme	signalling	121:130	arg1	pathway					132:138	ERK signalling pathway	117:138	ERK signalling pathway	117:138	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway.
34296452	5	95	theme	neurotrophic	989:1000	arg1	factors					1002:1008	neurotrophic factors	989:1008	neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF)	989:1089	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	5	95	theme	neurotrophic	989:1000	arg1	factor					1077:1082	brain-derived neurotrophic factor	1050:1082	brain-derived neurotrophic factor (BDNF)	1050:1089	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	5	95	theme	neurotrophic	989:1000	arg1	factor					1033:1038	nerve growth factor	1020:1038	nerve growth factor (NGF)	1020:1044	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	4	96	theme	kinase	865:870	arg1	expression					821:830	increased expression	811:830	increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43)	811:920	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	8	97	theme	CNTs-CaP/CS-AZ91D	1442:1458	arg1	extracts					1460:1467	CNTs-CaP/CS-AZ91D extracts	1442:1467	CNTs-CaP/CS-AZ91D extracts	1442:1467	Notably, CNTs-CaP/CS-AZ91D extracts showed a better promoting effect on neuron growth than CaP/CS-AZ91D.
34296452	12	98	theme	AZ91D	2210:2214	arg1	alloy					2226:2230	CaP/CS-coated AZ91D magnesium alloy	2196:2230	CaP/CS-coated AZ91D magnesium alloy	2196:2230	Both extracts from CNTs-CaP/CS and CaP/CS-coated AZ91D magnesium alloy promotes rat dorsal root ganglia (DRG) neuron growth via activating ERK signalling pathway.
34296452	6	99	theme	beneficial	1254:1263	arg1	effects					1265:1271	the beneficial effects	1250:1271	the beneficial effects of these extracts on DRG neuron	1250:1303	ERK signalling was activated in DRG neurons after treating with either CNTs-CaP/CS-AZ91D or CaP/CS-AZ91D extracts, and its inhibition with U0126 counteracted the beneficial effects of these extracts on DRG neuron.
34296452	0	100	theme	AZ91D	25:29	arg1	extract					47:53	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract	0:53	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract	0:53	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway.
34296452	6	101	from	effects	1265:1271	arg1	neuron					1298:1303	DRG neuron	1294:1303	DRG neuron	1294:1303	ERK signalling was activated in DRG neurons after treating with either CNTs-CaP/CS-AZ91D or CaP/CS-AZ91D extracts, and its inhibition with U0126 counteracted the beneficial effects of these extracts on DRG neuron.
34296452	4	102	theme	neuronal	633:640	arg1	TUJ1					663:666	TUJ1	663:666	TUJ1	663:666	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	4	102	theme	neuronal	633:640	arg1	β-tubulin					652:660	neuronal class III β-tubulin	633:660	neuronal class III β-tubulin (TUJ1)	633:667	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	0	103	theme	alloy	41:45	arg1	extract					47:53	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract	0:53	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract	0:53	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway.
34296452	8	104	theme	better	1478:1483	arg1	effect					1495:1500	a better promoting effect	1476:1500	a better promoting effect on neuron growth than CaP/CS-AZ91D	1476:1535	Notably, CNTs-CaP/CS-AZ91D extracts showed a better promoting effect on neuron growth than CaP/CS-AZ91D.
34296452	10	105	theme	suitable	1809:1816	arg1	environment					1818:1828	a more suitable environment	1802:1828	a more suitable environment	1802:1828	These findings demonstrate that CNTs-CaP/CS-AZ91D likely provide a more suitable environment for neuron growth, which suggests a potential implantable biomaterial for the treatment of nerve injury.
34296452	3	106	theme	AZ91D-based	443:453	arg1	composites					455:464	these AZ91D-based composites	437:464	these AZ91D-based composites	437:464	To evaluate the bioactivity of these AZ91D-based composites, the extracts were prepared by immersing samples in modified simulated body fluid (m-SBF) for 0, 2, 8, 16, 24, 34, 44, 60, or 90 days.
34296452	4	107	theme	associated	891:900	arg1	GAP-43					914:919	GAP-43	914:919	GAP-43	914:919	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	4	107	theme	associated	891:900	arg1	protein-43					902:911	growth associated protein-43	884:911	growth associated protein-43 (GAP-43)	884:920	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	4	108	theme	CaP/CS-AZ91D	710:721	arg1	extracts					723:730	both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts	683:730	both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts	683:730	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	9	109	theme	CaP/CS-AZ91D	1717:1728	arg1	alloy					1730:1734	CaP/CS-AZ91D alloy	1717:1734	CaP/CS-AZ91D alloy	1717:1734	Assessment of ion elements showed that the addition of CNTs coating enhanced magnesium corrosion resistance and reduced the deposition of calcium and phosphorus on the surface of CaP/CS-AZ91D alloy.
34296452	0	110	theme	dorsal	68:73	arg1	ganglia					80:86	rat dorsal root ganglia	64:86	rat dorsal root ganglia neuron growth	64:100	CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway.
34296452	5	111	link	brain-derived	1050:1062	arg1	factor					1077:1082	brain-derived neurotrophic factor	1050:1082	brain-derived neurotrophic factor (BDNF)	1050:1089	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	5	111	link	brain-derived	1050:1062	arg1	BDNF					1085:1088	BDNF	1085:1088	BDNF	1085:1088	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	11	112	theme	modified	2116:2123	arg1	fluid					2140:2144	modified simulated body fluid	2116:2144	modified simulated body fluid	2116:2144	SIGNIFICANCE: AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated and their immersion extracts were prepared using modified simulated body fluid in this study.
34296452	8	113	theme	neuron	1505:1510	arg1	growth					1512:1517	neuron growth	1505:1517	neuron growth	1505:1517	Notably, CNTs-CaP/CS-AZ91D extracts showed a better promoting effect on neuron growth than CaP/CS-AZ91D.
34296452	2	114	theme	calcium	338:344	arg1	CaP					357:359	CaP	357:359	CaP	357:359	AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated in this study.
34296452	2	114	theme	calcium	338:344	arg1	phosphate					346:354	calcium phosphate	338:354	calcium phosphate (CaP)/chitosan (CS)	338:374	AZ91D magnesium alloy coated with carbon nanotubes (CNTs) and/or calcium phosphate (CaP)/chitosan (CS) was fabricated in this study.
34296452	5	115	theme	brain-derived	1050:1062	arg1	factor					1077:1082	brain-derived neurotrophic factor	1050:1082	brain-derived neurotrophic factor (BDNF)	1050:1089	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	5	115	theme	brain-derived	1050:1062	arg1	BDNF					1085:1088	BDNF	1085:1088	BDNF	1085:1088	Besides, the extracts increased the expression and the release of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
34296452	7	116	theme	ERK	1409:1411	arg1	pathway					1424:1430	ERK signalling pathway	1409:1430	ERK signalling pathway	1409:1430	Overall, the extracts from these AZ91D-based composites might promote DRG neuron growth via activating ERK signalling pathway.
34296452	9	117	theme	ion	1552:1554	arg1	elements					1556:1563	ion elements	1552:1563	ion elements	1552:1563	Assessment of ion elements showed that the addition of CNTs coating enhanced magnesium corrosion resistance and reduced the deposition of calcium and phosphorus on the surface of CaP/CS-AZ91D alloy.
34296452	4	118	theme	CNTs-CaP/CS-AZ91D	688:704	arg1	extracts					723:730	both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts	683:730	both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts	683:730	Immunofluorescence staining for neuronal class III β-tubulin (TUJ1) revealed that both CNTs-CaP/CS-AZ91D and CaP/CS-AZ91D extracts promoted axon outgrowth of dorsal root ganglia (DRG) neurons, accompanied with increased expression of phosphorylated focal adhesion kinase (p-FAK) and growth associated protein-43 (GAP-43).
34296452	14	119	theme	potential	2565:2573	arg1	composites					2551:2560	these AZ91D-based composites	2533:2560	these AZ91D-based composites	2533:2560	For the first time, our research demonstrates that CNTs-CaP/CS-AZ91D likely provide a suitable environment for neuron growth, suggesting these AZ91D-based composites as potential implantable biomaterials for the treatment of nerve injury.
34296452	14	119	theme	potential	2565:2573	arg1	biomaterials					2587:2598	potential implantable biomaterials	2565:2598	potential implantable biomaterials for the treatment of nerve injury	2565:2632	For the first time, our research demonstrates that CNTs-CaP/CS-AZ91D likely provide a suitable environment for neuron growth, suggesting these AZ91D-based composites as potential implantable biomaterials for the treatment of nerve injury.
32347191	0	0	theme	biomass	86:92	arg1	properties					61:70	the fuel properties	52:70	the fuel properties of indigenous biomass (bagasse)	52:102	Impacts of non-oxidative torrefaction conditions on the fuel properties of indigenous biomass (bagasse).
32347191	5	1	theme	elemental	722:730	arg1	composition					732:742	the elemental composition	718:742	the elemental composition	718:742	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	4	2	theme	60	660:661	arg1	times					647:651	residence times	637:651	residence times of 30, 60 and 90 mins	637:673	In this work, torrefaction of bagasse was performed in a bench-scale tubular reactor at 250°C and 275°C with residence times of 30, 60 and 90 mins.
32347191	1	3	theme	renewable	142:150	arg1	source					159:164	the largest renewable energy source	130:164	the largest renewable energy source in the world	130:177	Biomass is considered as the largest renewable energy source in the world.
32347191	1	3	theme	renewable	142:150	arg1	Biomass					105:111	Biomass	105:111	Biomass	105:111	Biomass is considered as the largest renewable energy source in the world.
32347191	4	4	theme	bagasse	558:564	arg1	torrefaction					542:553	torrefaction	542:553	torrefaction of bagasse	542:564	In this work, torrefaction of bagasse was performed in a bench-scale tubular reactor at 250°C and 275°C with residence times of 30, 60 and 90 mins.
32347191	0	5	theme	indigenous	75:84	arg1	bagasse					95:101	bagasse	95:101	bagasse	95:101	Impacts of non-oxidative torrefaction conditions on the fuel properties of indigenous biomass (bagasse).
32347191	0	5	theme	indigenous	75:84	arg1	biomass					86:92	indigenous biomass	75:92	indigenous biomass (bagasse)	75:102	Impacts of non-oxidative torrefaction conditions on the fuel properties of indigenous biomass (bagasse).
32347191	5	6	theme	higher	825:830	arg1	values					840:845	higher heating values	825:845	higher heating values	825:845	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	1	7	theme	energy	152:157	arg1	source					159:164	the largest renewable energy source	130:164	the largest renewable energy source in the world	130:177	Biomass is considered as the largest renewable energy source in the world.
32347191	1	7	theme	energy	152:157	arg1	Biomass					105:111	Biomass	105:111	Biomass	105:111	Biomass is considered as the largest renewable energy source in the world.
32347191	8	8	from	hydrophobicity	1435:1448	arg1	bagasse					1457:1463	the bagasse	1453:1463	the bagasse	1453:1463	The structural and thermal analysis of the torrefied bagasse indicates that the moisture, non-structural carbohydrates and hemicellulose were reduced, which induced the hydrophobicity in the bagasse and enhanced its energy value.
32347191	0	9	from	Impacts	0:6	arg1	properties					61:70	the fuel properties	52:70	the fuel properties of indigenous biomass (bagasse)	52:102	Impacts of non-oxidative torrefaction conditions on the fuel properties of indigenous biomass (bagasse).
32347191	7	10	theme	high	1231:1234	arg1	value					1244:1248	a high heating value	1229:1248	a high heating value of 23.84 MJ/kg	1229:1263	Torrefaction of the bagasse conducted at 275°C and 90 min raised the carbon content in bagasse to 58.14% and resulted in a high heating value of 23.84 MJ/kg.
32347191	2	11	from	bio-degradation	288:302	arg1	storage					307:313	storage	307:313	storage	307:313	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	2	12	from	density	276:282	arg1	storage					307:313	storage	307:313	storage	307:313	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	6	13	theme	optimal	1045:1051	arg1	250°C					1089:1093	250°C	1089:1093	250°C	1089:1093	Based on the targeted mass and energy yields of 80% and 90% respectively, the optimal process conditions turned out to be 250°C and 30 mins.
32347191	6	13	theme	optimal	1045:1051	arg1	conditions					1061:1070	the optimal process conditions	1041:1070	the optimal process conditions	1041:1070	Based on the targeted mass and energy yields of 80% and 90% respectively, the optimal process conditions turned out to be 250°C and 30 mins.
32347191	7	14	theme	bagasse	1128:1134	arg1	Torrefaction					1108:1119	Torrefaction	1108:1119	Torrefaction of the bagasse conducted at 275°C and 90 min	1108:1164	Torrefaction of the bagasse conducted at 275°C and 90 min raised the carbon content in bagasse to 58.14% and resulted in a high heating value of 23.84 MJ/kg.
32347191	2	15	theme	extensive	326:334	arg1	application					336:346	its extensive application	322:346	its extensive application in energy generation processes	322:377	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	5	16	theme	torrefaction	691:702	arg1	conditions					704:713	torrefaction conditions	691:713	torrefaction conditions	691:713	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	6	17	theme	%	1025:1025	arg1	mass					989:992	targeted mass	980:992	targeted mass	980:992	Based on the targeted mass and energy yields of 80% and 90% respectively, the optimal process conditions turned out to be 250°C and 30 mins.
32347191	6	17	theme	%	1025:1025	arg1	yields					1005:1010	energy yields	998:1010	energy yields	998:1010	Based on the targeted mass and energy yields of 80% and 90% respectively, the optimal process conditions turned out to be 250°C and 30 mins.
32347191	2	18	theme	energy	251:256	arg1	content					258:264	lower energy content	245:264	lower energy content	245:264	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	6	19	theme	targeted	980:987	arg1	mass					989:992	targeted mass	980:992	targeted mass	980:992	Based on the targeted mass and energy yields of 80% and 90% respectively, the optimal process conditions turned out to be 250°C and 30 mins.
32347191	5	20	theme	hydrogen/carbon	795:809	arg1	ratios					817:822	mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios	745:822	mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios	745:822	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	5	21	theme	conditions	704:713	arg1	effects					680:686	The effects	676:686	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition	676:872	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	5	22	theme	heating	832:838	arg1	values					840:845	higher heating values	825:845	higher heating values	825:845	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	9	23	theme	sustainable	1545:1555	arg1	torrefaction					1523:1534	torrefaction	1523:1534	torrefaction	1523:1534	These findings showed that torrefaction can be a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes.
32347191	9	23	theme	sustainable	1545:1555	arg1	process					1571:1577	a sustainable pre-treatment process	1543:1577	a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes	1543:1681	These findings showed that torrefaction can be a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes.
32347191	2	24	theme	lower	245:249	arg1	content					258:264	lower energy content	245:264	lower energy content	245:264	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	6	25	theme	energy	998:1003	arg1	yields					1005:1010	energy yields	998:1010	energy yields	998:1010	Based on the targeted mass and energy yields of 80% and 90% respectively, the optimal process conditions turned out to be 250°C and 30 mins.
32347191	8	26	theme	energy	1482:1487	arg1	value					1489:1493	its energy value	1478:1493	its energy value	1478:1493	The structural and thermal analysis of the torrefied bagasse indicates that the moisture, non-structural carbohydrates and hemicellulose were reduced, which induced the hydrophobicity in the bagasse and enhanced its energy value.
32347191	5	27	theme	energy	757:762	arg1	yield					764:768	energy yield	757:768	energy yield	757:768	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	9	28	theme	pre-treatment	1557:1569	arg1	torrefaction					1523:1534	torrefaction	1523:1534	torrefaction	1523:1534	These findings showed that torrefaction can be a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes.
32347191	9	28	theme	pre-treatment	1557:1569	arg1	process					1571:1577	a sustainable pre-treatment process	1543:1577	a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes	1543:1681	These findings showed that torrefaction can be a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes.
32347191	9	29	theme	biomass	1628:1634	arg1	feedstock					1641:1649	a feedstock	1639:1649	a feedstock for energy generation processes	1639:1681	These findings showed that torrefaction can be a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes.
32347191	9	29	theme	biomass	1628:1634	arg1	properties					1614:1623	the fuel and structural properties	1590:1623	the fuel and structural properties of biomass	1590:1634	These findings showed that torrefaction can be a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes.
32347191	1	30	dep	renewable	142:150	arg1	largest					134:140	largest	134:140	largest	134:140	Biomass is considered as the largest renewable energy source in the world.
32347191	4	31	from	275°C	626:630	arg1	reactor					605:611	a bench-scale tubular reactor	583:611	a bench-scale tubular reactor at 250°C and 275°C	583:630	In this work, torrefaction of bagasse was performed in a bench-scale tubular reactor at 250°C and 275°C with residence times of 30, 60 and 90 mins.
32347191	2	32	theme	generation	358:367	arg1	processes					369:377	energy generation processes	351:377	energy generation processes	351:377	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	5	33	theme	yield	764:768	arg1	ratios					817:822	mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios	745:822	mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios	745:822	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	9	34	theme	generation	1662:1671	arg1	processes					1673:1681	energy generation processes	1655:1681	energy generation processes	1655:1681	These findings showed that torrefaction can be a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes.
32347191	2	35	theme	energy	351:356	arg1	processes					369:377	energy generation processes	351:377	energy generation processes	351:377	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	0	36	theme	torrefaction	25:36	arg1	conditions					38:47	non-oxidative torrefaction conditions	11:47	non-oxidative torrefaction conditions	11:47	Impacts of non-oxidative torrefaction conditions on the fuel properties of indigenous biomass (bagasse).
32347191	9	37	theme	energy	1655:1660	arg1	processes					1673:1681	energy generation processes	1655:1681	energy generation processes	1655:1681	These findings showed that torrefaction can be a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes.
32347191	2	38	from	application	336:346	arg1	processes					369:377	energy generation processes	351:377	energy generation processes	351:377	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	2	39	theme	mass	271:274	arg1	density					276:282	low mass density	267:282	low mass density	267:282	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	4	40	from	250°C	616:620	arg1	reactor					605:611	a bench-scale tubular reactor	583:611	a bench-scale tubular reactor at 250°C and 275°C	583:630	In this work, torrefaction of bagasse was performed in a bench-scale tubular reactor at 250°C and 275°C with residence times of 30, 60 and 90 mins.
32347191	0	41	theme	non-oxidative	11:23	arg1	conditions					38:47	non-oxidative torrefaction conditions	11:47	non-oxidative torrefaction conditions	11:47	Impacts of non-oxidative torrefaction conditions on the fuel properties of indigenous biomass (bagasse).
32347191	7	42	from	content	1184:1190	arg1	bagasse					1195:1201	bagasse	1195:1201	bagasse	1195:1201	Torrefaction of the bagasse conducted at 275°C and 90 min raised the carbon content in bagasse to 58.14% and resulted in a high heating value of 23.84 MJ/kg.
32347191	2	43	theme	low	267:269	arg1	density					276:282	low mass density	267:282	low mass density	267:282	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	3	44	theme	non-oxidative	449:461	arg1	environment					463:473	a non-oxidative environment	447:473	a non-oxidative environment	447:473	Torrefaction, a thermochemical process carried out at 200-300°C in a non-oxidative environment, can address these inherent problems of the biomass.
32347191	2	45	from	hygroscopicity	229:242	arg1	storage					307:313	storage	307:313	storage	307:313	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	0	46	theme	conditions	38:47	arg1	Impacts					0:6	Impacts	0:6	Impacts of non-oxidative torrefaction conditions on the fuel properties of indigenous biomass (bagasse).	0:103	Impacts of non-oxidative torrefaction conditions on the fuel properties of indigenous biomass (bagasse).
32347191	3	47	theme	thermochemical	396:409	arg1	process					411:417	a thermochemical process	394:417	a thermochemical process carried out at 200-300°C in a non-oxidative environment	394:473	Torrefaction, a thermochemical process carried out at 200-300°C in a non-oxidative environment, can address these inherent problems of the biomass.
32347191	3	47	theme	thermochemical	396:409	arg1	Torrefaction					380:391	Torrefaction	380:391	Torrefaction	380:391	Torrefaction, a thermochemical process carried out at 200-300°C in a non-oxidative environment, can address these inherent problems of the biomass.
32347191	5	48	from	effects	680:686	arg1	ratios					817:822	mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios	745:822	mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios	745:822	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	5	48	from	effects	680:686	arg1	composition					732:742	the elemental composition	718:742	the elemental composition	718:742	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	5	48	from	effects	680:686	arg1	values					840:845	higher heating values	825:845	higher heating values	825:845	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	5	48	from	effects	680:686	arg1	composition					862:872	structural composition	851:872	structural composition	851:872	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	2	49	theme	inherent	201:208	arg1	content					258:264	lower energy content	245:264	lower energy content	245:264	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	2	49	theme	inherent	201:208	arg1	hygroscopicity					229:242	hygroscopicity	229:242	hygroscopicity	229:242	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	2	49	theme	inherent	201:208	arg1	bio-degradation					288:302	bio-degradation	288:302	bio-degradation	288:302	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	2	49	theme	inherent	201:208	arg1	properties					210:219	its inherent properties	197:219	its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage	197:313	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	2	49	theme	inherent	201:208	arg1	density					276:282	low mass density	267:282	low mass density	267:282	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	7	50	theme	heating	1236:1242	arg1	value					1244:1248	a high heating value	1229:1248	a high heating value of 23.84 MJ/kg	1229:1263	Torrefaction of the bagasse conducted at 275°C and 90 min raised the carbon content in bagasse to 58.14% and resulted in a high heating value of 23.84 MJ/kg.
32347191	7	51	theme	carbon	1177:1182	arg1	content					1184:1190	the carbon content	1173:1190	the carbon content in bagasse	1173:1201	Torrefaction of the bagasse conducted at 275°C and 90 min raised the carbon content in bagasse to 58.14% and resulted in a high heating value of 23.84 MJ/kg.
32347191	0	52	theme	fuel	56:59	arg1	properties					61:70	the fuel properties	52:70	the fuel properties of indigenous biomass (bagasse)	52:102	Impacts of non-oxidative torrefaction conditions on the fuel properties of indigenous biomass (bagasse).
32347191	8	53	theme	torrefied	1309:1317	arg1	bagasse					1319:1325	the torrefied bagasse	1305:1325	the torrefied bagasse	1305:1325	The structural and thermal analysis of the torrefied bagasse indicates that the moisture, non-structural carbohydrates and hemicellulose were reduced, which induced the hydrophobicity in the bagasse and enhanced its energy value.
32347191	5	54	theme	Tunnel	951:956	arg1	coal					961:964	'Tunnel C' coal	950:964	'Tunnel C' coal	950:964	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	4	55	theme	90 mins	667:673	arg1	times					647:651	residence times	637:651	residence times of 30, 60 and 90 mins	637:673	In this work, torrefaction of bagasse was performed in a bench-scale tubular reactor at 250°C and 275°C with residence times of 30, 60 and 90 mins.
32347191	9	56	theme	fuel	1594:1597	arg1	feedstock					1641:1649	a feedstock	1639:1649	a feedstock for energy generation processes	1639:1681	These findings showed that torrefaction can be a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes.
32347191	9	56	theme	fuel	1594:1597	arg1	properties					1614:1623	the fuel and structural properties	1590:1623	the fuel and structural properties of biomass	1590:1634	These findings showed that torrefaction can be a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes.
32347191	9	57	theme	structural	1603:1612	arg1	feedstock					1641:1649	a feedstock	1639:1649	a feedstock for energy generation processes	1639:1681	These findings showed that torrefaction can be a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes.
32347191	9	57	theme	structural	1603:1612	arg1	properties					1614:1623	the fuel and structural properties	1590:1623	the fuel and structural properties of biomass	1590:1634	These findings showed that torrefaction can be a sustainable pre-treatment process to improve the fuel and structural properties of biomass as a feedstock for energy generation processes.
32347191	6	58	dep	mass	989:992	arg1	the					976:978	the	976:978	the	976:978	Based on the targeted mass and energy yields of 80% and 90% respectively, the optimal process conditions turned out to be 250°C and 30 mins.
32347191	5	59	theme	C'	958:959	arg1	coal					961:964	'Tunnel C' coal	950:964	'Tunnel C' coal	950:964	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	3	60	theme	inherent	494:501	arg1	problems					503:510	these inherent problems	488:510	these inherent problems of the biomass	488:525	Torrefaction, a thermochemical process carried out at 200-300°C in a non-oxidative environment, can address these inherent problems of the biomass.
32347191	4	61	theme	residence	637:645	arg1	times					647:651	residence times	637:651	residence times of 30, 60 and 90 mins	637:673	In this work, torrefaction of bagasse was performed in a bench-scale tubular reactor at 250°C and 275°C with residence times of 30, 60 and 90 mins.
32347191	8	62	theme	thermal	1285:1291	arg1	analysis					1293:1300	The structural and thermal analysis	1266:1300	The structural and thermal analysis of the torrefied bagasse	1266:1325	The structural and thermal analysis of the torrefied bagasse indicates that the moisture, non-structural carbohydrates and hemicellulose were reduced, which induced the hydrophobicity in the bagasse and enhanced its energy value.
32347191	5	63	theme	mass	745:748	arg1	yield					750:754	mass yield	745:754	mass yield	745:754	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	5	64	theme	structural	851:860	arg1	composition					862:872	structural composition	851:872	structural composition	851:872	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	7	65	theme	MJ/kg	1259:1263	arg1	value					1244:1248	a high heating value	1229:1248	a high heating value of 23.84 MJ/kg	1229:1263	Torrefaction of the bagasse conducted at 275°C and 90 min raised the carbon content in bagasse to 58.14% and resulted in a high heating value of 23.84 MJ/kg.
32347191	3	66	theme	biomass	519:525	arg1	problems					503:510	these inherent problems	488:510	these inherent problems of the biomass	488:525	Torrefaction, a thermochemical process carried out at 200-300°C in a non-oxidative environment, can address these inherent problems of the biomass.
32347191	8	67	theme	structural	1270:1279	arg1	analysis					1293:1300	The structural and thermal analysis	1266:1300	The structural and thermal analysis of the torrefied bagasse	1266:1325	The structural and thermal analysis of the torrefied bagasse indicates that the moisture, non-structural carbohydrates and hemicellulose were reduced, which induced the hydrophobicity in the bagasse and enhanced its energy value.
32347191	6	68	theme	%	1017:1017	arg1	mass					989:992	targeted mass	980:992	targeted mass	980:992	Based on the targeted mass and energy yields of 80% and 90% respectively, the optimal process conditions turned out to be 250°C and 30 mins.
32347191	6	68	theme	%	1017:1017	arg1	yields					1005:1010	energy yields	998:1010	energy yields	998:1010	Based on the targeted mass and energy yields of 80% and 90% respectively, the optimal process conditions turned out to be 250°C and 30 mins.
32347191	8	69	theme	bagasse	1319:1325	arg1	analysis					1293:1300	The structural and thermal analysis	1266:1300	The structural and thermal analysis of the torrefied bagasse	1266:1325	The structural and thermal analysis of the torrefied bagasse indicates that the moisture, non-structural carbohydrates and hemicellulose were reduced, which induced the hydrophobicity in the bagasse and enhanced its energy value.
32347191	6	70	theme	process	1053:1059	arg1	250°C					1089:1093	250°C	1089:1093	250°C	1089:1093	Based on the targeted mass and energy yields of 80% and 90% respectively, the optimal process conditions turned out to be 250°C and 30 mins.
32347191	6	70	theme	process	1053:1059	arg1	conditions					1061:1070	the optimal process conditions	1041:1070	the optimal process conditions	1041:1070	Based on the targeted mass and energy yields of 80% and 90% respectively, the optimal process conditions turned out to be 250°C and 30 mins.
32347191	4	71	theme	30	656:657	arg1	times					647:651	residence times	637:651	residence times of 30, 60 and 90 mins	637:673	In this work, torrefaction of bagasse was performed in a bench-scale tubular reactor at 250°C and 275°C with residence times of 30, 60 and 90 mins.
32347191	2	72	from	content	258:264	arg1	storage					307:313	storage	307:313	storage	307:313	However, some of its inherent properties such as hygroscopicity, lower energy content, low mass density and bio-degradation on storage hinder its extensive application in energy generation processes.
32347191	4	73	theme	tubular	597:603	arg1	reactor					605:611	a bench-scale tubular reactor	583:611	a bench-scale tubular reactor at 250°C and 275°C	583:630	In this work, torrefaction of bagasse was performed in a bench-scale tubular reactor at 250°C and 275°C with residence times of 30, 60 and 90 mins.
32347191	5	74	theme	yield	750:754	arg1	ratios					817:822	mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios	745:822	mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios	745:822	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	8	75	theme	non-structural	1356:1369	arg1	carbohydrates					1371:1383	non-structural carbohydrates	1356:1383	non-structural carbohydrates	1356:1383	The structural and thermal analysis of the torrefied bagasse indicates that the moisture, non-structural carbohydrates and hemicellulose were reduced, which induced the hydrophobicity in the bagasse and enhanced its energy value.
32347191	5	76	theme	oxygen/carbon	771:783	arg1	ratios					817:822	mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios	745:822	mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios	745:822	The effects of torrefaction conditions on the elemental composition, mass yield, energy yield, oxygen/carbon (O/C) and hydrogen/carbon (H/C) ratios, higher heating values and structural composition were investigated and compared with the commercially available 'Thar 6' and 'Tunnel C' coal.
32347191	1	77	from	source	159:164	arg1	world					173:177	the world	169:177	the world	169:177	Biomass is considered as the largest renewable energy source in the world.
32347191	4	78	theme	bench-scale	585:595	arg1	reactor					605:611	a bench-scale tubular reactor	583:611	a bench-scale tubular reactor at 250°C and 275°C	583:630	In this work, torrefaction of bagasse was performed in a bench-scale tubular reactor at 250°C and 275°C with residence times of 30, 60 and 90 mins.
34626101	0	0	theme	Conductive	85:94	arg1	Microfibers					120:130	Conductive Graphene-Laden Alginate Microfibers	85:130	Conductive Graphene-Laden Alginate Microfibers	85:130	Behavior of Neural Cells Post Manufacturing and After Prolonged Encapsulation within Conductive Graphene-Laden Alginate Microfibers.
34626101	8	1	from	changes	1567:1573	arg1	expressions					1583:1593	gene expressions	1578:1593	gene expressions	1578:1593	Long-term encapsulation of neural cells in alginate and 6-day exposure to graphene also leads to changes in gene expressions.
34626101	3	2	theme	native	597:602	arg1	tissue					610:615	native brain tissue	597:615	native brain tissue	597:615	Incorporating graphene increases the conductivity of the alginate microfibers by 148%, creating a similar conductivity to native brain tissue.
34626101	4	3	theme	%	674:674	arg1	efficiency					658:667	an efficiency	655:667	an efficiency of 50%	655:674	The cell encapsulation procedure has an efficiency of 50%, and of those cells, ≈30% remain for the entire 6-day observation period.
34626101	5	4	theme	tubulin	844:850	arg1	class					859:863	tubulin beta 3 class 3	844:865	tubulin beta 3 class 3	844:865	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	5	5	theme	real-time	947:955	arg1	reaction					1009:1016	real-time reverse transcription-quantitative polymerase chain reaction	947:1016	real-time reverse transcription-quantitative polymerase chain reaction	947:1016	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	3	6	theme	brain	604:608	arg1	tissue					610:615	native brain tissue	597:615	native brain tissue	597:615	Incorporating graphene increases the conductivity of the alginate microfibers by 148%, creating a similar conductivity to native brain tissue.
34626101	8	7	theme	cells	1504:1508	arg1	encapsulation					1480:1492	Long-term encapsulation	1470:1492	Long-term encapsulation of neural cells in alginate and 6-day exposure to graphene	1470:1551	Long-term encapsulation of neural cells in alginate and 6-day exposure to graphene also leads to changes in gene expressions.
34626101	0	8	theme	Alginate	111:118	arg1	Microfibers					120:130	Conductive Graphene-Laden Alginate Microfibers	85:130	Conductive Graphene-Laden Alginate Microfibers	85:130	Behavior of Neural Cells Post Manufacturing and After Prolonged Encapsulation within Conductive Graphene-Laden Alginate Microfibers.
34626101	2	9	theme	alginate	363:370	arg1	microfibers					372:382	graphene-laden alginate microfibers	348:382	graphene-laden alginate microfibers using a microfluidic approach, which is unmatched for creating highly-tunable microfibers	348:472	Dopaminergic neural cells are encapsulated into graphene-laden alginate microfibers using a microfluidic approach, which is unmatched for creating highly-tunable microfibers.
34626101	5	10	theme	enzyme-linked	1039:1051	arg1	assay					1067:1071	enzyme-linked immunosorbent assay	1039:1071	enzyme-linked immunosorbent assay	1039:1071	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	0	11	theme	Graphene-Laden	96:109	arg1	Microfibers					120:130	Conductive Graphene-Laden Alginate Microfibers	85:130	Conductive Graphene-Laden Alginate Microfibers	85:130	Behavior of Neural Cells Post Manufacturing and After Prolonged Encapsulation within Conductive Graphene-Laden Alginate Microfibers.
34626101	2	12	theme	graphene-laden	348:361	arg1	microfibers					372:382	graphene-laden alginate microfibers	348:382	graphene-laden alginate microfibers using a microfluidic approach, which is unmatched for creating highly-tunable microfibers	348:472	Dopaminergic neural cells are encapsulated into graphene-laden alginate microfibers using a microfluidic approach, which is unmatched for creating highly-tunable microfibers.
34626101	3	13	theme	similar	573:579	arg1	conductivity					581:592	a similar conductivity	571:592	a similar conductivity to native brain tissue	571:615	Incorporating graphene increases the conductivity of the alginate microfibers by 148%, creating a similar conductivity to native brain tissue.
34626101	5	14	theme	transcription-quantitative	965:990	arg1	reaction					1009:1016	real-time reverse transcription-quantitative polymerase chain reaction	947:1016	real-time reverse transcription-quantitative polymerase chain reaction	947:1016	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	8	15	theme	gene	1578:1581	arg1	expressions					1583:1593	gene expressions	1578:1593	gene expressions	1578:1593	Long-term encapsulation of neural cells in alginate and 6-day exposure to graphene also leads to changes in gene expressions.
34626101	5	16	theme	chain	1003:1007	arg1	reaction					1009:1016	real-time reverse transcription-quantitative polymerase chain reaction	947:1016	real-time reverse transcription-quantitative polymerase chain reaction	947:1016	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	3	17	theme	microfibers	541:551	arg1	conductivity					512:523	the conductivity	508:523	the conductivity of the alginate microfibers	508:551	Incorporating graphene increases the conductivity of the alginate microfibers by 148%, creating a similar conductivity to native brain tissue.
34626101	6	18	theme	manufacturing	1259:1271	arg1	process					1273:1279	the manufacturing process	1255:1279	the manufacturing process	1255:1279	Preliminary data shows that the manufacturing process and combination with alginate matrix affect the expression of the studied genes immediately after manufacturing.
34626101	7	19	theme	gene	1452:1455	arg1	expressions					1457:1467	gene expressions	1452:1467	gene expressions	1452:1467	In addition, the introduction of graphene further changes gene expressions.
34626101	3	20	theme	Incorporating	475:487	arg1	graphene					489:496	Incorporating graphene	475:496	Incorporating graphene	475:496	Incorporating graphene increases the conductivity of the alginate microfibers by 148%, creating a similar conductivity to native brain tissue.
34626101	6	21	theme	genes	1355:1359	arg1	expression					1329:1338	the expression	1325:1338	the expression of the studied genes	1325:1359	Preliminary data shows that the manufacturing process and combination with alginate matrix affect the expression of the studied genes immediately after manufacturing.
34626101	2	22	theme	microfluidic	392:403	arg1	approach					405:412	a microfluidic approach	390:412	a microfluidic approach	390:412	Dopaminergic neural cells are encapsulated into graphene-laden alginate microfibers using a microfluidic approach, which is unmatched for creating highly-tunable microfibers.
34626101	2	22	theme	microfluidic	392:403	arg1	unmatched					424:432	unmatched	424:432	unmatched	424:432	Dopaminergic neural cells are encapsulated into graphene-laden alginate microfibers using a microfluidic approach, which is unmatched for creating highly-tunable microfibers.
34626101	5	23	theme	graphene-polymer	1188:1203	arg1	composite					1205:1213	the graphene-polymer composite	1184:1213	the graphene-polymer composite	1184:1213	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	4	24	theme	observation	730:740	arg1	period					742:747	the entire 6-day observation period	713:747	the entire 6-day observation period	713:747	The cell encapsulation procedure has an efficiency of 50%, and of those cells, ≈30% remain for the entire 6-day observation period.
34626101	5	25	theme	interleukin	868:878	arg1	beta					882:885	interleukin 1 beta	868:885	interleukin 1 beta	868:885	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	6	26	with	process	1273:1279	arg1	matrix					1311:1316	alginate matrix	1302:1316	alginate matrix	1302:1316	Preliminary data shows that the manufacturing process and combination with alginate matrix affect the expression of the studied genes immediately after manufacturing.
34626101	6	27	theme	studied	1347:1353	arg1	genes					1355:1359	the studied genes	1343:1359	the studied genes	1343:1359	Preliminary data shows that the manufacturing process and combination with alginate matrix affect the expression of the studied genes immediately after manufacturing.
34626101	5	28	theme	factor	907:912	arg1	alfa					914:917	tumor necrosis factor alfa	892:917	tumor necrosis factor alfa	892:917	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	3	29	theme	alginate	532:539	arg1	microfibers					541:551	the alginate microfibers	528:551	the alginate microfibers	528:551	Incorporating graphene increases the conductivity of the alginate microfibers by 148%, creating a similar conductivity to native brain tissue.
34626101	0	30	theme	Cells	19:23	arg1	Behavior					0:7	Behavior	0:7	Behavior of Neural Cells Post Manufacturing and After Prolonged Encapsulation within Conductive Graphene-Laden Alginate Microfibers.	0:131	Behavior of Neural Cells Post Manufacturing and After Prolonged Encapsulation within Conductive Graphene-Laden Alginate Microfibers.
34626101	6	31	theme	alginate	1302:1309	arg1	matrix					1311:1316	alginate matrix	1302:1316	alginate matrix	1302:1316	Preliminary data shows that the manufacturing process and combination with alginate matrix affect the expression of the studied genes immediately after manufacturing.
34626101	4	32	contain	has	651:653	arg1	procedure					641:649	The cell encapsulation procedure	618:649	The cell encapsulation procedure	618:649	The cell encapsulation procedure has an efficiency of 50%, and of those cells, ≈30% remain for the entire 6-day observation period.
34626101	4	32	contain	has	651:653	arg2	efficiency					658:667	an efficiency	655:667	an efficiency of 50%	655:674	The cell encapsulation procedure has an efficiency of 50%, and of those cells, ≈30% remain for the entire 6-day observation period.
34626101	1	33	theme	relevant	233:240	arg1	platforms					242:250	physiologically relevant platforms	217:250	physiologically relevant platforms with integrated real-time sensing capabilities	217:297	Engineering conductive 3D cell scaffoldings offer advantages toward the creation of physiologically relevant platforms with integrated real-time sensing capabilities.
34626101	0	34	theme	Neural	12:17	arg1	Cells					19:23	Neural Cells	12:23	Neural Cells	12:23	Behavior of Neural Cells Post Manufacturing and After Prolonged Encapsulation within Conductive Graphene-Laden Alginate Microfibers.
34626101	6	35	with	combination	1285:1295	arg1	matrix					1311:1316	alginate matrix	1302:1316	alginate matrix	1302:1316	Preliminary data shows that the manufacturing process and combination with alginate matrix affect the expression of the studied genes immediately after manufacturing.
34626101	5	36	theme	reverse	957:963	arg1	reaction					1009:1016	real-time reverse transcription-quantitative polymerase chain reaction	947:1016	real-time reverse transcription-quantitative polymerase chain reaction	947:1016	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	5	37	from	encapsulation	1113:1125	arg1	matrix					1138:1143	polymer matrix	1130:1143	polymer matrix for 6 days	1130:1154	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	1	38	theme	platforms	242:250	arg1	creation					205:212	the creation	201:212	the creation of physiologically relevant platforms with integrated real-time sensing capabilities	201:297	Engineering conductive 3D cell scaffoldings offer advantages toward the creation of physiologically relevant platforms with integrated real-time sensing capabilities.
34626101	5	39	theme	beta	852:855	arg1	class					859:863	tubulin beta 3 class 3	844:865	tubulin beta 3 class 3	844:865	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	5	40	theme	polymerase	992:1001	arg1	reaction					1009:1016	real-time reverse transcription-quantitative polymerase chain reaction	947:1016	real-time reverse transcription-quantitative polymerase chain reaction	947:1016	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	5	41	theme	microfluidic	772:783	arg1	encapsulation					785:797	the microfluidic encapsulation	768:797	the microfluidic encapsulation	768:797	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	4	42	theme	6-day	724:728	arg1	period					742:747	the entire 6-day observation period	713:747	the entire 6-day observation period	713:747	The cell encapsulation procedure has an efficiency of 50%, and of those cells, ≈30% remain for the entire 6-day observation period.
34626101	5	43	theme	tumor	892:896	arg1	alfa					914:917	tumor necrosis factor alfa	892:917	tumor necrosis factor alfa	892:917	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	4	44	theme	entire	717:722	arg1	period					742:747	the entire 6-day observation period	713:747	the entire 6-day observation period	713:747	The cell encapsulation procedure has an efficiency of 50%, and of those cells, ≈30% remain for the entire 6-day observation period.
34626101	4	45	theme	cell	622:625	arg1	procedure					641:649	The cell encapsulation procedure	618:649	The cell encapsulation procedure	618:649	The cell encapsulation procedure has an efficiency of 50%, and of those cells, ≈30% remain for the entire 6-day observation period.
34626101	1	46	with	platforms	242:250	arg1	capabilities					286:297	integrated real-time sensing capabilities	257:297	integrated real-time sensing capabilities	257:297	Engineering conductive 3D cell scaffoldings offer advantages toward the creation of physiologically relevant platforms with integrated real-time sensing capabilities.
34626101	7	47	theme	graphene	1427:1434	arg1	introduction					1411:1422	the introduction	1407:1422	the introduction of graphene	1407:1434	In addition, the introduction of graphene further changes gene expressions.
34626101	1	48	theme	integrated	257:266	arg1	capabilities					286:297	integrated real-time sensing capabilities	257:297	integrated real-time sensing capabilities	257:297	Engineering conductive 3D cell scaffoldings offer advantages toward the creation of physiologically relevant platforms with integrated real-time sensing capabilities.
34626101	5	49	from	encapsulation	1167:1179	arg1	composite					1205:1213	the graphene-polymer composite	1184:1213	the graphene-polymer composite	1184:1213	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	8	50	theme	neural	1497:1502	arg1	cells					1504:1508	neural cells	1497:1508	neural cells	1497:1508	Long-term encapsulation of neural cells in alginate and 6-day exposure to graphene also leads to changes in gene expressions.
34626101	5	51	link	enzyme-linked	1039:1051	arg1	assay					1067:1071	enzyme-linked immunosorbent assay	1039:1071	enzyme-linked immunosorbent assay	1039:1071	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	5	52	theme	polymer	1130:1136	arg1	matrix					1138:1143	polymer matrix	1130:1143	polymer matrix for 6 days	1130:1154	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	1	53	theme	Engineering	133:143	arg1	scaffoldings					164:175	Engineering conductive 3D cell scaffoldings	133:175	Engineering conductive 3D cell scaffoldings	133:175	Engineering conductive 3D cell scaffoldings offer advantages toward the creation of physiologically relevant platforms with integrated real-time sensing capabilities.
34626101	8	54	theme	6-day	1526:1530	arg1	exposure					1532:1539	6-day exposure	1526:1539	6-day exposure to graphene	1526:1551	Long-term encapsulation of neural cells in alginate and 6-day exposure to graphene also leads to changes in gene expressions.
34626101	1	55	theme	conductive	145:154	arg1	scaffoldings					164:175	Engineering conductive 3D cell scaffoldings	133:175	Engineering conductive 3D cell scaffoldings	133:175	Engineering conductive 3D cell scaffoldings offer advantages toward the creation of physiologically relevant platforms with integrated real-time sensing capabilities.
34626101	8	56	from	encapsulation	1480:1492	arg1	alginate					1513:1520	alginate	1513:1520	alginate	1513:1520	Long-term encapsulation of neural cells in alginate and 6-day exposure to graphene also leads to changes in gene expressions.
34626101	8	56	from	encapsulation	1480:1492	arg1	exposure					1532:1539	6-day exposure	1526:1539	6-day exposure to graphene	1526:1551	Long-term encapsulation of neural cells in alginate and 6-day exposure to graphene also leads to changes in gene expressions.
34626101	4	57	theme	encapsulation	627:639	arg1	procedure					641:649	The cell encapsulation procedure	618:649	The cell encapsulation procedure	618:649	The cell encapsulation procedure has an efficiency of 50%, and of those cells, ≈30% remain for the entire 6-day observation period.
34626101	1	58	theme	3D	156:157	arg1	scaffoldings					164:175	Engineering conductive 3D cell scaffoldings	133:175	Engineering conductive 3D cell scaffoldings	133:175	Engineering conductive 3D cell scaffoldings offer advantages toward the creation of physiologically relevant platforms with integrated real-time sensing capabilities.
34626101	1	59	theme	real-time	268:276	arg1	capabilities					286:297	integrated real-time sensing capabilities	257:297	integrated real-time sensing capabilities	257:297	Engineering conductive 3D cell scaffoldings offer advantages toward the creation of physiologically relevant platforms with integrated real-time sensing capabilities.
34626101	8	60	theme	Long-term	1470:1478	arg1	encapsulation					1480:1492	Long-term encapsulation	1470:1492	Long-term encapsulation of neural cells in alginate and 6-day exposure to graphene	1470:1551	Long-term encapsulation of neural cells in alginate and 6-day exposure to graphene also leads to changes in gene expressions.
34626101	5	61	theme	immunosorbent	1053:1065	arg1	assay					1067:1071	enzyme-linked immunosorbent assay	1039:1071	enzyme-linked immunosorbent assay	1039:1071	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	1	62	theme	cell	159:162	arg1	scaffoldings					164:175	Engineering conductive 3D cell scaffoldings	133:175	Engineering conductive 3D cell scaffoldings	133:175	Engineering conductive 3D cell scaffoldings offer advantages toward the creation of physiologically relevant platforms with integrated real-time sensing capabilities.
34626101	6	63	theme	Preliminary	1227:1237	arg1	data					1239:1242	Preliminary data	1227:1242	Preliminary data	1227:1242	Preliminary data shows that the manufacturing process and combination with alginate matrix affect the expression of the studied genes immediately after manufacturing.
34626101	1	64	theme	sensing	278:284	arg1	capabilities					286:297	integrated real-time sensing capabilities	257:297	integrated real-time sensing capabilities	257:297	Engineering conductive 3D cell scaffoldings offer advantages toward the creation of physiologically relevant platforms with integrated real-time sensing capabilities.
34626101	5	65	theme	tyrosine	822:829	arg1	hydroxylase					831:841	tyrosine hydroxylase	822:841	tyrosine hydroxylase	822:841	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	5	66	theme	necrosis	898:905	arg1	alfa					914:917	tumor necrosis factor alfa	892:917	tumor necrosis factor alfa	892:917	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
34626101	2	67	theme	neural	313:318	arg1	cells					320:324	Dopaminergic neural cells	300:324	Dopaminergic neural cells	300:324	Dopaminergic neural cells are encapsulated into graphene-laden alginate microfibers using a microfluidic approach, which is unmatched for creating highly-tunable microfibers.
34626101	2	68	theme	highly-tunable	447:460	arg1	microfibers					462:472	highly-tunable microfibers	447:472	highly-tunable microfibers	447:472	Dopaminergic neural cells are encapsulated into graphene-laden alginate microfibers using a microfluidic approach, which is unmatched for creating highly-tunable microfibers.
34626101	0	69	theme	Prolonged	54:62	arg1	Encapsulation					64:76	Prolonged Encapsulation	54:76	Prolonged Encapsulation within Conductive Graphene-Laden Alginate Microfibers	54:130	Behavior of Neural Cells Post Manufacturing and After Prolonged Encapsulation within Conductive Graphene-Laden Alginate Microfibers.
34626101	2	70	theme	Dopaminergic	300:311	arg1	cells					320:324	Dopaminergic neural cells	300:324	Dopaminergic neural cells	300:324	Dopaminergic neural cells are encapsulated into graphene-laden alginate microfibers using a microfluidic approach, which is unmatched for creating highly-tunable microfibers.
34626101	5	71	theme	cell	807:810	arg1	genetics					812:819	cell genetics	807:819	cell genetics	807:819	To understand how the microfluidic encapsulation affects cell genetics, tyrosine hydroxylase, tubulin beta 3 class 3, interleukin 1 beta, and tumor necrosis factor alfa are analyzed primarily with real-time reverse transcription-quantitative polymerase chain reaction and secondarily with enzyme-linked immunosorbent assay, immediately after manufacturing, after encapsulation in polymer matrix for 6 days, and after encapsulation in the graphene-polymer composite for 6 days.
33142623	0	0	theme	HPAEC-PAD-MS	85:96	arg1	system					98:103	A HPAEC-PAD-MS system	83:103	A HPAEC-PAD-MS system	83:103	Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system.
33142623	6	1	theme	glucan	920:925	arg1	hooked					938:943	hooked	938:943	hooked through one or two 1→3 linked glucose residues	938:990	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	6	1	theme	glucan	920:925	arg1	chains					927:932	multiple 1→6 linked glucan chains	900:932	multiple 1→6 linked glucan chains	900:932	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	1	2	theme	erinaceus	162:170	arg1	body					145:148	fruiting body	136:148	fruiting body of Hericium erinaceus	136:170	A water-soluble β-glucan from fruiting body of Hericium erinaceus was obtained after water extraction, purification and fractionation.
33142623	4	3	theme	bond	591:594	arg1	mode					567:570	The linkage mode	555:570	The linkage mode of each glycosidic bond in the digested oligosaccharides	555:627	The linkage mode of each glycosidic bond in the digested oligosaccharides were confirmed with MS/MS.
33142623	0	4	from	elucidation	11:21	arg1	erinaceus					68:76	Hericium erinaceus	59:76	Hericium erinaceus	59:76	Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system.
33142623	4	5	theme	glycosidic	580:589	arg1	bond					591:594	each glycosidic bond	575:594	each glycosidic bond	575:594	The linkage mode of each glycosidic bond in the digested oligosaccharides were confirmed with MS/MS.
33142623	5	6	theme	1→6	740:742	arg1	glucoses					751:758	several 1→6 linked glucoses	732:758	several 1→6 linked glucoses with one or two 1→3 linked glucose residues	732:802	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	5	6	theme	1→6	740:742	arg1	oligosaccharides					698:713	enzyme resistant oligosaccharides	681:713	enzyme resistant oligosaccharides	681:713	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	2	7	with	weight	397:402	arg1	1→3					355:357	1→3	355:357	1→3	355:357	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	2	7	with	weight	397:402	arg1	1→6					363:365	1→6	363:365	1→6	363:365	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	6	8	link	linked	968:973	arg1	residues					983:990	one or two 1→3 linked glucose residues	953:990	one or two 1→3 linked glucose residues	953:990	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	3	9	used	used	447:450	arg2	endo-1,6-β-d-glucanase					420:441	An endo-1,6-β-d-glucanase	417:441	An endo-1,6-β-d-glucanase	417:441	An endo-1,6-β-d-glucanase was used to digest the β-glucan and the digested products over time were analyzed with a HPAEC-PAD-MS platform.
33142623	2	10	dep	1→3	355:357	arg1	modes					375:379	linkage modes	367:379	linkage modes	367:379	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	7	11	from	glucoses	1046:1053	arg1	β-glucan					1080:1087	this branch-on-branch β-glucan	1058:1087	this branch-on-branch β-glucan	1058:1087	Averagely, there is a 1→3 linkage per six 1→6 linked glucoses in this branch-on-branch β-glucan.
33142623	5	12	theme	linked	744:749	arg1	glucoses					751:758	several 1→6 linked glucoses	732:758	several 1→6 linked glucoses with one or two 1→3 linked glucose residues	732:802	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	5	12	theme	linked	744:749	arg1	oligosaccharides					698:713	enzyme resistant oligosaccharides	681:713	enzyme resistant oligosaccharides	681:713	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	6	13	theme	multiple	900:907	arg1	hooked					938:943	hooked	938:943	hooked through one or two 1→3 linked glucose residues	938:990	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	6	13	theme	multiple	900:907	arg1	chains					927:932	multiple 1→6 linked glucan chains	900:932	multiple 1→6 linked glucan chains	900:932	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	5	14	theme	digestion	670:678	arg1	end					663:665	the end	659:665	the end of digestion	659:678	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	2	15	theme	mode	310:313	arg1	Analyses					241:248	Analyses	241:248	Analyses of monosaccharide composition, molecular weight and linkage mode	241:313	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	5	16	located	observed	720:727	arg1	end					663:665	the end	659:665	the end of digestion	659:678	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	5	16	located	observed	720:727	arg2	oligosaccharides					698:713	enzyme resistant oligosaccharides	681:713	enzyme resistant oligosaccharides	681:713	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	5	16	located	observed	720:727	arg2	glucoses					751:758	several 1→6 linked glucoses	732:758	several 1→6 linked glucoses with one or two 1→3 linked glucose residues	732:802	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	6	17	theme	glucose	975:981	arg1	residues					983:990	one or two 1→3 linked glucose residues	953:990	one or two 1→3 linked glucose residues	953:990	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	6	18	dep	linked	913:918	arg1	1→6					909:911	1→6	909:911	1→6	909:911	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	2	19	theme	linkage	302:308	arg1	mode					310:313	linkage mode	302:313	linkage mode	302:313	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	2	20	theme	molecular	387:395	arg1	weight					397:402	a molecular weight	385:402	a molecular weight of 13.3 kDa	385:414	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	6	21	link	linked	913:918	arg1	hooked					938:943	hooked	938:943	hooked through one or two 1→3 linked glucose residues	938:990	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	6	21	link	linked	913:918	arg1	chains					927:932	multiple 1→6 linked glucan chains	900:932	multiple 1→6 linked glucan chains	900:932	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	5	22	theme	linked	780:785	arg1	residues					795:802	one or two 1→3 linked glucose residues	765:802	one or two 1→3 linked glucose residues	765:802	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	4	23	theme	digested	603:610	arg1	oligosaccharides					612:627	the digested oligosaccharides	599:627	the digested oligosaccharides	599:627	The linkage mode of each glycosidic bond in the digested oligosaccharides were confirmed with MS/MS.
33142623	1	24	from	body	145:148	arg1	β-glucan					122:129	A water-soluble β-glucan	106:129	A water-soluble β-glucan from fruiting body of Hericium erinaceus	106:170	A water-soluble β-glucan from fruiting body of Hericium erinaceus was obtained after water extraction, purification and fractionation.
33142623	1	25	theme	water	191:195	arg1	extraction					197:206	water extraction	191:206	water extraction	191:206	A water-soluble β-glucan from fruiting body of Hericium erinaceus was obtained after water extraction, purification and fractionation.
33142623	0	26	theme	Structural	0:9	arg1	elucidation					11:21	Structural elucidation	0:21	Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system.	0:104	Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system.
33142623	6	27	theme	linked	968:973	arg1	residues					983:990	one or two 1→3 linked glucose residues	953:990	one or two 1→3 linked glucose residues	953:990	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	7	28	theme	branch-on-branch	1063:1078	arg1	β-glucan					1080:1087	this branch-on-branch β-glucan	1058:1087	this branch-on-branch β-glucan	1058:1087	Averagely, there is a 1→3 linkage per six 1→6 linked glucoses in this branch-on-branch β-glucan.
33142623	6	29	theme	branch-on-branch	866:881	arg1	glucan					883:888	a branch-on-branch glucan	864:888	a branch-on-branch glucan	864:888	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	4	30	from	mode	567:570	arg1	oligosaccharides					612:627	the digested oligosaccharides	599:627	the digested oligosaccharides	599:627	The linkage mode of each glycosidic bond in the digested oligosaccharides were confirmed with MS/MS.
33142623	4	31	theme	linkage	559:565	arg1	mode					567:570	The linkage mode	555:570	The linkage mode of each glycosidic bond in the digested oligosaccharides	555:627	The linkage mode of each glycosidic bond in the digested oligosaccharides were confirmed with MS/MS.
33142623	5	32	with	glucoses	751:758	arg1	residues					795:802	one or two 1→3 linked glucose residues	765:802	one or two 1→3 linked glucose residues	765:802	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	3	33	theme	HPAEC-PAD-MS	532:543	arg1	platform					545:552	a HPAEC-PAD-MS platform	530:552	a HPAEC-PAD-MS platform	530:552	An endo-1,6-β-d-glucanase was used to digest the β-glucan and the digested products over time were analyzed with a HPAEC-PAD-MS platform.
33142623	1	34	theme	water-soluble	108:120	arg1	β-glucan					122:129	A water-soluble β-glucan	106:129	A water-soluble β-glucan from fruiting body of Hericium erinaceus	106:170	A water-soluble β-glucan from fruiting body of Hericium erinaceus was obtained after water extraction, purification and fractionation.
33142623	0	35	theme	β-glucan	45:52	arg1	elucidation					11:21	Structural elucidation	0:21	Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system.	0:104	Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system.
33142623	7	36	theme	1→6	1035:1037	arg1	glucoses					1046:1053	six 1→6 linked glucoses	1031:1053	six 1→6 linked glucoses in this branch-on-branch β-glucan	1031:1087	Averagely, there is a 1→3 linkage per six 1→6 linked glucoses in this branch-on-branch β-glucan.
33142623	2	37	with	β-glucan	341:348	arg1	1→3					355:357	1→3	355:357	1→3	355:357	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	2	37	with	β-glucan	341:348	arg1	1→6					363:365	1→6	363:365	1→6	363:365	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	2	38	theme	monosaccharide	253:266	arg1	composition					268:278	monosaccharide composition	253:278	monosaccharide composition	253:278	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	0	39	theme	branch-on-branch	28:43	arg1	β-glucan					45:52	a branch-on-branch β-glucan	26:52	a branch-on-branch β-glucan from Hericium erinaceus	26:76	Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system.
33142623	5	40	theme	glucose	787:793	arg1	residues					795:802	one or two 1→3 linked glucose residues	765:802	one or two 1→3 linked glucose residues	765:802	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	6	41	from	glucan	883:888	arg1	pieces					852:857	more like constructional pieces	827:857	more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues	827:990	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	6	41	from	glucan	883:888	arg1	domains					815:821	All these domains	805:821	All these domains	805:821	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	2	42	theme	13.3 kDa	407:414	arg1	weight					397:402	a molecular weight	385:402	a molecular weight of 13.3 kDa	385:414	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	2	42	theme	13.3 kDa	407:414	arg1	it					333:334	it	333:334	it	333:334	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	2	42	theme	13.3 kDa	407:414	arg1	β-glucan					341:348	a β-glucan	339:348	a β-glucan with 1→3 and 1→6 linkage modes	339:379	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	0	43	theme	Hericium	59:66	arg1	erinaceus					68:76	Hericium erinaceus	59:76	Hericium erinaceus	59:76	Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system.
33142623	6	44	from	hooked	938:943	arg1	glucan					883:888	a branch-on-branch glucan	864:888	a branch-on-branch glucan	864:888	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	0	45	from	erinaceus	68:76	arg1	β-glucan					45:52	a branch-on-branch β-glucan	26:52	a branch-on-branch β-glucan from Hericium erinaceus	26:76	Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system.
33142623	0	45	from	erinaceus	68:76	arg1	elucidation					11:21	Structural elucidation	0:21	Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system.	0:104	Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system.
33142623	5	46	link	linked	780:785	arg1	residues					795:802	one or two 1→3 linked glucose residues	765:802	one or two 1→3 linked glucose residues	765:802	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	7	47	theme	1→3	1015:1017	arg1	linkage					1019:1025	a 1→3 linkage	1013:1025	a 1→3 linkage per six 1→6 linked glucoses in this branch-on-branch β-glucan	1013:1087	Averagely, there is a 1→3 linkage per six 1→6 linked glucoses in this branch-on-branch β-glucan.
33142623	7	48	theme	linked	1039:1044	arg1	glucoses					1046:1053	six 1→6 linked glucoses	1031:1053	six 1→6 linked glucoses in this branch-on-branch β-glucan	1031:1087	Averagely, there is a 1→3 linkage per six 1→6 linked glucoses in this branch-on-branch β-glucan.
33142623	5	49	theme	several	732:738	arg1	glucoses					751:758	several 1→6 linked glucoses	732:758	several 1→6 linked glucoses with one or two 1→3 linked glucose residues	732:802	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	5	49	theme	several	732:738	arg1	oligosaccharides					698:713	enzyme resistant oligosaccharides	681:713	enzyme resistant oligosaccharides	681:713	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	5	50	theme	enzyme	681:686	arg1	glucoses					751:758	several 1→6 linked glucoses	732:758	several 1→6 linked glucoses with one or two 1→3 linked glucose residues	732:802	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	5	50	theme	enzyme	681:686	arg1	oligosaccharides					698:713	enzyme resistant oligosaccharides	681:713	enzyme resistant oligosaccharides	681:713	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	6	51	theme	linked	913:918	arg1	hooked					938:943	hooked	938:943	hooked through one or two 1→3 linked glucose residues	938:990	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	6	51	theme	linked	913:918	arg1	chains					927:932	multiple 1→6 linked glucan chains	900:932	multiple 1→6 linked glucan chains	900:932	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	0	52	with	elucidation	11:21	arg1	system					98:103	A HPAEC-PAD-MS system	83:103	A HPAEC-PAD-MS system	83:103	Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system.
33142623	5	53	theme	resistant	688:696	arg1	glucoses					751:758	several 1→6 linked glucoses	732:758	several 1→6 linked glucoses with one or two 1→3 linked glucose residues	732:802	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	5	53	theme	resistant	688:696	arg1	oligosaccharides					698:713	enzyme resistant oligosaccharides	681:713	enzyme resistant oligosaccharides	681:713	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	6	54	theme	constructional	837:850	arg1	pieces					852:857	more like constructional pieces	827:857	more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues	827:990	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	6	54	theme	constructional	837:850	arg1	domains					815:821	All these domains	805:821	All these domains	805:821	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	2	55	theme	weight	291:296	arg1	Analyses					241:248	Analyses	241:248	Analyses of monosaccharide composition, molecular weight and linkage mode	241:313	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	1	56	theme	fruiting	136:143	arg1	body					145:148	fruiting body	136:148	fruiting body of Hericium erinaceus	136:170	A water-soluble β-glucan from fruiting body of Hericium erinaceus was obtained after water extraction, purification and fractionation.
33142623	5	57	link	linked	744:749	arg1	glucoses					751:758	several 1→6 linked glucoses	732:758	several 1→6 linked glucoses with one or two 1→3 linked glucose residues	732:802	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	5	57	link	linked	744:749	arg1	oligosaccharides					698:713	enzyme resistant oligosaccharides	681:713	enzyme resistant oligosaccharides	681:713	At the end of digestion, enzyme resistant oligosaccharides were observed as several 1→6 linked glucoses with one or two 1→3 linked glucose residues.
33142623	6	58	theme	like	832:835	arg1	pieces					852:857	more like constructional pieces	827:857	more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues	827:990	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	6	58	theme	like	832:835	arg1	domains					815:821	All these domains	805:821	All these domains	805:821	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	2	59	theme	molecular	281:289	arg1	weight					291:296	molecular weight	281:296	molecular weight	281:296	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	7	60	link	linked	1039:1044	arg1	glucoses					1046:1053	six 1→6 linked glucoses	1031:1053	six 1→6 linked glucoses in this branch-on-branch β-glucan	1031:1087	Averagely, there is a 1→3 linkage per six 1→6 linked glucoses in this branch-on-branch β-glucan.
33142623	3	61	theme	digested	483:490	arg1	products					492:499	the digested products	479:499	the digested products over time	479:509	An endo-1,6-β-d-glucanase was used to digest the β-glucan and the digested products over time were analyzed with a HPAEC-PAD-MS platform.
33142623	6	62	theme	more	827:830	arg1	pieces					852:857	more like constructional pieces	827:857	more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues	827:990	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	6	62	theme	more	827:830	arg1	domains					815:821	All these domains	805:821	All these domains	805:821	All these domains are more like constructional pieces from a branch-on-branch glucan, in which multiple 1→6 linked glucan chains are hooked through one or two 1→3 linked glucose residues.
33142623	2	63	theme	linkage	367:373	arg1	modes					375:379	linkage modes	367:379	linkage modes	367:379	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	2	64	theme	composition	268:278	arg1	Analyses					241:248	Analyses	241:248	Analyses of monosaccharide composition, molecular weight and linkage mode	241:313	Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa.
33142623	1	65	theme	Hericium	153:160	arg1	erinaceus					162:170	Hericium erinaceus	153:170	Hericium erinaceus	153:170	A water-soluble β-glucan from fruiting body of Hericium erinaceus was obtained after water extraction, purification and fractionation.
33270789	0	0	theme	milk	94:97	arg1	samples					99:105	feline milk samples	87:105	feline milk samples	87:105	High-throughput glycomic analyses reveal unique oligosaccharide profiles of canine and feline milk samples.
33270789	11	1	theme	Difucosyllactose-N-hexaose	1383:1408	arg1	b					1410:1410	Difucosyllactose-N-hexaose b	1383:1410	Difucosyllactose-N-hexaose b	1383:1410	Difucosyllactose-N-hexaose b, 3'-sialyllactose and lacto-N-neohexaose were all detected at abundances >10% in feline milk samples.
33270789	4	2	theme	domestic	715:722	arg1	cats					734:737	6 domestic shorthair cats	713:737	6 domestic shorthair cats	713:737	23 dogs (9 Labrador retriever and 14 Labrador retriever x golden retriever crossbreed) and 6 domestic shorthair cats were recruited to the study.
33270789	2	3	theme	milk	389:392	arg1	samples					394:400	feline milk samples	382:400	feline milk samples	382:400	Nutrient composition of canine and feline milk samples has been described previously, but little is known about the oligosaccharide content.
33270789	12	4	theme	oligosaccharide	1564:1578	arg1	abundances					1580:1589	oligosaccharide abundances	1564:1589	oligosaccharide abundances	1564:1589	Statistically significant differences (p<0.05) in oligosaccharide abundances were observed between collection time points and between diet groups within species.
33270789	0	5	theme	feline	87:92	arg1	samples					99:105	feline milk samples	87:105	feline milk samples	87:105	High-throughput glycomic analyses reveal unique oligosaccharide profiles of canine and feline milk samples.
33270789	8	6	theme	milk	1059:1062	arg1	samples					1064:1070	canine milk samples	1052:1070	canine milk samples	1052:1070	In canine milk samples, 3 structures accounted for over 90% of all oligosaccharides detected across two diet groups.
33270789	2	7	theme	feline	382:387	arg1	samples					394:400	feline milk samples	382:400	feline milk samples	382:400	Nutrient composition of canine and feline milk samples has been described previously, but little is known about the oligosaccharide content.
33270789	10	8	theme	oligosaccharides	1279:1294	arg1	range					1270:1274	a more diverse range	1255:1274	a more diverse range of oligosaccharides	1255:1294	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	11	9	theme	milk	1500:1503	arg1	samples					1505:1511	feline milk samples	1493:1511	feline milk samples	1493:1511	Difucosyllactose-N-hexaose b, 3'-sialyllactose and lacto-N-neohexaose were all detected at abundances >10% in feline milk samples.
33270789	6	10	theme	maternal	921:928	arg1	diet					930:933	maternal diet	921:933	maternal diet	921:933	Samples were collected across 2 phases per species, differentiated by maternal diet.
33270789	7	11	theme	liquid	1000:1005	arg1	LC-MS					1041:1045	LC-MS	1041:1045	LC-MS	1041:1045	Following extraction, oligosaccharide content was determined by liquid chromatography-mass spectrometry (LC-MS).
33270789	7	11	theme	liquid	1000:1005	arg1	spectrometry					1027:1038	liquid chromatography-mass spectrometry	1000:1038	liquid chromatography-mass spectrometry (LC-MS)	1000:1046	Following extraction, oligosaccharide content was determined by liquid chromatography-mass spectrometry (LC-MS).
33270789	3	12	theme	milk	565:568	arg1	samples					570:576	canine and feline milk samples	547:576	samples	570:576	Therefore, the objective of this study was to characterize canine and feline milk samples using a high-throughput glycomics approach.
33270789	13	13	theme	kittens	1876:1882	arg1	nutritional					1834:1844	nutritional	1834:1844	nutritional	1834:1844	These data explore the oligosaccharide content of canine and feline maternal milk, representing an opportunity to generate a fundamental understanding of the nutritional needs of new-born puppies and kittens.
33270789	10	14	theme	feline	1239:1244	arg1	samples					1246:1252	feline samples	1239:1252	feline samples	1239:1252	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	0	15	theme	samples	99:105	arg1	profiles					64:71	unique oligosaccharide profiles	41:71	unique oligosaccharide profiles of canine and feline milk samples	41:105	High-throughput glycomic analyses reveal unique oligosaccharide profiles of canine and feline milk samples.
33270789	0	16	theme	High-throughput	0:14	arg1	analyses					25:32	High-throughput glycomic analyses	0:32	High-throughput glycomic analyses	0:32	High-throughput glycomic analyses reveal unique oligosaccharide profiles of canine and feline milk samples.
33270789	11	17	theme	abundances	1474:1483	arg1	%					1488:1488	abundances >10%	1474:1488	abundances >10%	1474:1488	Difucosyllactose-N-hexaose b, 3'-sialyllactose and lacto-N-neohexaose were all detected at abundances >10% in feline milk samples.
33270789	13	18	theme	new-born	1855:1862	arg1	puppies					1864:1870	new-born puppies	1855:1870	new-born puppies	1855:1870	These data explore the oligosaccharide content of canine and feline maternal milk, representing an opportunity to generate a fundamental understanding of the nutritional needs of new-born puppies and kittens.
33270789	5	19	theme	time	820:823	arg1	points					825:830	time points	820:830	time points after parturition	820:848	Milk samples were collected by manual expression at time points after parturition.
33270789	10	20	from	%	1367:1367	arg1	present					1335:1341	present	1335:1341	present	1335:1341	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	13	21	theme	nutritional	1834:1844	arg1	understanding					1813:1825	a fundamental understanding	1799:1825	a fundamental understanding of the nutritional needs of new-born puppies and kittens	1799:1882	These data explore the oligosaccharide content of canine and feline maternal milk, representing an opportunity to generate a fundamental understanding of the nutritional needs of new-born puppies and kittens.
33270789	13	22	theme	feline	1737:1742	arg1	milk					1753:1756	feline maternal milk	1737:1756	feline maternal milk	1737:1756	These data explore the oligosaccharide content of canine and feline maternal milk, representing an opportunity to generate a fundamental understanding of the nutritional needs of new-born puppies and kittens.
33270789	7	23	theme	oligosaccharide	958:972	arg1	content					974:980	oligosaccharide content	958:980	oligosaccharide content	958:980	Following extraction, oligosaccharide content was determined by liquid chromatography-mass spectrometry (LC-MS).
33270789	1	24	dep	components	139:148	arg1	acting					212:217	acting	212:217	acting as antimicrobials that prevent pathogen colonization	212:270	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	1	24	dep	components	139:148	arg1	supporting					277:286	supporting	277:286	supporting the developing gastrointestinal immune system of neonates	277:344	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	1	24	dep	components	139:148	arg1	serving					159:165	serving	159:165	serving as substrates for the intestinal microbiota	159:209	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	0	25	theme	glycomic	16:23	arg1	analyses					25:32	High-throughput glycomic analyses	0:32	High-throughput glycomic analyses	0:32	High-throughput glycomic analyses reveal unique oligosaccharide profiles of canine and feline milk samples.
33270789	3	26	theme	canine	547:552	arg1	samples					570:576	canine and feline milk samples	547:576	samples	570:576	Therefore, the objective of this study was to characterize canine and feline milk samples using a high-throughput glycomics approach.
33270789	13	27	theme	maternal	1744:1751	arg1	milk					1753:1756	feline maternal milk	1737:1756	feline maternal milk	1737:1756	These data explore the oligosaccharide content of canine and feline maternal milk, representing an opportunity to generate a fundamental understanding of the nutritional needs of new-born puppies and kittens.
33270789	2	28	theme	Nutrient	347:354	arg1	composition					356:366	Nutrient composition	347:366	Nutrient composition of canine and feline milk samples	347:400	Nutrient composition of canine and feline milk samples has been described previously, but little is known about the oligosaccharide content.
33270789	1	29	theme	intestinal	189:198	arg1	microbiota					200:209	the intestinal microbiota	185:209	the intestinal microbiota	185:209	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	2	30	theme	oligosaccharide	463:477	arg1	content					479:485	the oligosaccharide content	459:485	the oligosaccharide content	459:485	Nutrient composition of canine and feline milk samples has been described previously, but little is known about the oligosaccharide content.
33270789	1	31	theme	developing	292:301	arg1	system					327:332	the developing gastrointestinal immune system	288:332	the developing gastrointestinal immune system of neonates	288:344	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	1	31	theme	developing	292:301	arg1	substrates					170:179	substrates	170:179	substrates for the intestinal microbiota	170:209	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	13	32	theme	milk	1753:1756	arg1	content					1715:1721	the oligosaccharide content	1695:1721	the oligosaccharide content of canine and feline maternal milk	1695:1756	These data explore the oligosaccharide content of canine and feline maternal milk, representing an opportunity to generate a fundamental understanding of the nutritional needs of new-born puppies and kittens.
33270789	8	33	theme	canine	1052:1057	arg1	samples					1064:1070	canine milk samples	1052:1070	canine milk samples	1052:1070	In canine milk samples, 3 structures accounted for over 90% of all oligosaccharides detected across two diet groups.
33270789	3	34	theme	glycomics	602:610	arg1	approach					612:619	a high-throughput glycomics approach	584:619	a high-throughput glycomics approach	584:619	Therefore, the objective of this study was to characterize canine and feline milk samples using a high-throughput glycomics approach.
33270789	11	35	theme	feline	1493:1498	arg1	samples					1505:1511	feline milk samples	1493:1511	feline milk samples	1493:1511	Difucosyllactose-N-hexaose b, 3'-sialyllactose and lacto-N-neohexaose were all detected at abundances >10% in feline milk samples.
33270789	13	36	dep	nutritional	1834:1844	arg1	needs					1846:1850	needs	1846:1850	needs	1846:1850	These data explore the oligosaccharide content of canine and feline maternal milk, representing an opportunity to generate a fundamental understanding of the nutritional needs of new-born puppies and kittens.
33270789	1	37	theme	gastrointestinal	303:318	arg1	system					327:332	the developing gastrointestinal immune system	288:332	the developing gastrointestinal immune system of neonates	288:344	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	1	37	theme	gastrointestinal	303:318	arg1	substrates					170:179	substrates	170:179	substrates for the intestinal microbiota	170:209	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	13	38	theme	oligosaccharide	1699:1713	arg1	content					1715:1721	the oligosaccharide content	1695:1721	the oligosaccharide content of canine and feline maternal milk	1695:1756	These data explore the oligosaccharide content of canine and feline maternal milk, representing an opportunity to generate a fundamental understanding of the nutritional needs of new-born puppies and kittens.
33270789	10	39	theme	present	1335:1341	arg1	structures					1324:1333	up to 16 structures	1315:1333	up to 16 structures present at relative abundance >1% of the total	1315:1380	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	12	40	from	differences	1540:1550	arg1	abundances					1580:1589	oligosaccharide abundances	1564:1589	oligosaccharide abundances	1564:1589	Statistically significant differences (p<0.05) in oligosaccharide abundances were observed between collection time points and between diet groups within species.
33270789	1	41	theme	immune	320:325	arg1	system					327:332	the developing gastrointestinal immune system	288:332	the developing gastrointestinal immune system of neonates	288:344	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	1	41	theme	immune	320:325	arg1	substrates					170:179	substrates	170:179	substrates for the intestinal microbiota	170:209	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	4	42	dep	dogs	625:628	arg1	dogs					625:628	23 dogs	622:628	23 dogs (9 Labrador retriever and 14 Labrador retriever x golden retriever crossbreed)	622:707	23 dogs (9 Labrador retriever and 14 Labrador retriever x golden retriever crossbreed) and 6 domestic shorthair cats were recruited to the study.
33270789	4	42	dep	dogs	625:628	arg1	retriever					668:676	retriever	668:676	retriever	668:676	23 dogs (9 Labrador retriever and 14 Labrador retriever x golden retriever crossbreed) and 6 domestic shorthair cats were recruited to the study.
33270789	4	42	dep	dogs	625:628	arg1	retriever					642:650	retriever	642:650	retriever	642:650	23 dogs (9 Labrador retriever and 14 Labrador retriever x golden retriever crossbreed) and 6 domestic shorthair cats were recruited to the study.
33270789	0	43	theme	oligosaccharide	48:62	arg1	profiles					64:71	unique oligosaccharide profiles	41:71	unique oligosaccharide profiles of canine and feline milk samples	41:105	High-throughput glycomic analyses reveal unique oligosaccharide profiles of canine and feline milk samples.
33270789	3	44	theme	study	521:525	arg1	objective					503:511	the objective	499:511	the objective of this study	499:525	Therefore, the objective of this study was to characterize canine and feline milk samples using a high-throughput glycomics approach.
33270789	10	45	located	detected	1300:1307	arg2	range					1270:1274	a more diverse range	1255:1274	a more diverse range of oligosaccharides	1255:1294	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	10	45	located	detected	1300:1307	arg1	samples					1246:1252	feline samples	1239:1252	feline samples	1239:1252	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	0	46	theme	unique	41:46	arg1	profiles					64:71	unique oligosaccharide profiles	41:71	unique oligosaccharide profiles of canine and feline milk samples	41:105	High-throughput glycomic analyses reveal unique oligosaccharide profiles of canine and feline milk samples.
33270789	5	47	theme	manual	799:804	arg1	expression					806:815	manual expression	799:815	manual expression	799:815	Milk samples were collected by manual expression at time points after parturition.
33270789	12	48	theme	time	1624:1627	arg1	points					1629:1634	collection time points	1613:1634	collection time points	1613:1634	Statistically significant differences (p<0.05) in oligosaccharide abundances were observed between collection time points and between diet groups within species.
33270789	13	49	theme	puppies	1864:1870	arg1	nutritional					1834:1844	nutritional	1834:1844	nutritional	1834:1844	These data explore the oligosaccharide content of canine and feline maternal milk, representing an opportunity to generate a fundamental understanding of the nutritional needs of new-born puppies and kittens.
33270789	1	50	theme	neonates	337:344	arg1	system					327:332	the developing gastrointestinal immune system	288:332	the developing gastrointestinal immune system of neonates	288:344	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	1	50	theme	neonates	337:344	arg1	substrates					170:179	substrates	170:179	substrates for the intestinal microbiota	170:209	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	8	51	theme	diet	1153:1156	arg1	groups					1158:1163	two diet groups	1149:1163	two diet groups	1149:1163	In canine milk samples, 3 structures accounted for over 90% of all oligosaccharides detected across two diet groups.
33270789	10	52	dep	16	1321:1322	arg1	to					1318:1319	to	1318:1319	to	1318:1319	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	1	53	theme	important	129:137	arg1	Oligosaccharides					108:123	Oligosaccharides	108:123	Oligosaccharides	108:123	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	1	53	theme	important	129:137	arg1	components					139:148	important components	129:148	important components	129:148	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	13	54	theme	canine	1726:1731	arg1	content					1715:1721	the oligosaccharide content	1695:1721	the oligosaccharide content of canine and feline maternal milk	1695:1756	These data explore the oligosaccharide content of canine and feline maternal milk, representing an opportunity to generate a fundamental understanding of the nutritional needs of new-born puppies and kittens.
33270789	12	55	theme	diet	1648:1651	arg1	groups					1653:1658	diet groups	1648:1658	diet groups within species	1648:1673	Statistically significant differences (p<0.05) in oligosaccharide abundances were observed between collection time points and between diet groups within species.
33270789	8	56	theme	oligosaccharides	1116:1131	arg1	%					1107:1107	over 90%	1100:1107	over 90% of all oligosaccharides detected across two diet groups	1100:1163	In canine milk samples, 3 structures accounted for over 90% of all oligosaccharides detected across two diet groups.
33270789	8	56	theme	oligosaccharides	1116:1131	arg1	oligosaccharides					1116:1131	all oligosaccharides	1112:1131	all oligosaccharides detected across two diet groups	1112:1163	In canine milk samples, 3 structures accounted for over 90% of all oligosaccharides detected across two diet groups.
33270789	13	57	theme	fundamental	1801:1811	arg1	understanding					1813:1825	a fundamental understanding	1799:1825	a fundamental understanding of the nutritional needs of new-born puppies and kittens	1799:1882	These data explore the oligosaccharide content of canine and feline maternal milk, representing an opportunity to generate a fundamental understanding of the nutritional needs of new-born puppies and kittens.
33270789	10	58	theme	abundance	1355:1363	arg1	%					1367:1367	relative abundance >1%	1346:1367	relative abundance >1% of the total	1346:1380	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	10	58	theme	abundance	1355:1363	arg1	total					1376:1380	total	1376:1380	total	1376:1380	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	2	59	theme	canine	371:376	arg1	composition					356:366	Nutrient composition	347:366	Nutrient composition of canine and feline milk samples	347:400	Nutrient composition of canine and feline milk samples has been described previously, but little is known about the oligosaccharide content.
33270789	3	60	theme	high-throughput	586:600	arg1	approach					612:619	a high-throughput glycomics approach	584:619	a high-throughput glycomics approach	584:619	Therefore, the objective of this study was to characterize canine and feline milk samples using a high-throughput glycomics approach.
33270789	10	61	theme	relative	1346:1353	arg1	%					1367:1367	relative abundance >1%	1346:1367	relative abundance >1% of the total	1346:1380	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	10	61	theme	relative	1346:1353	arg1	total					1376:1380	total	1376:1380	total	1376:1380	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	10	62	theme	diverse	1262:1268	arg1	range					1270:1274	a more diverse range	1255:1274	a more diverse range of oligosaccharides	1255:1294	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	3	63	theme	feline	558:563	arg1	samples					570:576	canine and feline milk samples	547:576	samples	570:576	Therefore, the objective of this study was to characterize canine and feline milk samples using a high-throughput glycomics approach.
33270789	12	64	theme	significant	1528:1538	arg1	p<0.05					1553:1558	p<0.05	1553:1558	p<0.05	1553:1558	Statistically significant differences (p<0.05) in oligosaccharide abundances were observed between collection time points and between diet groups within species.
33270789	12	64	theme	significant	1528:1538	arg1	differences					1540:1550	Statistically significant differences	1514:1550	Statistically significant differences (p<0.05) in oligosaccharide abundances	1514:1589	Statistically significant differences (p<0.05) in oligosaccharide abundances were observed between collection time points and between diet groups within species.
33270789	1	65	theme	milk	153:156	arg1	Oligosaccharides					108:123	Oligosaccharides	108:123	Oligosaccharides	108:123	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	1	65	theme	milk	153:156	arg1	components					139:148	important components	129:148	important components	129:148	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	5	66	theme	Milk	768:771	arg1	samples					773:779	Milk samples	768:779	Milk samples	768:779	Milk samples were collected by manual expression at time points after parturition.
33270789	11	67	located	detected	1462:1469	arg1	samples					1505:1511	feline milk samples	1493:1511	feline milk samples	1493:1511	Difucosyllactose-N-hexaose b, 3'-sialyllactose and lacto-N-neohexaose were all detected at abundances >10% in feline milk samples.
33270789	11	67	located	detected	1462:1469	arg2	lacto-N-neohexaose					1434:1451	lacto-N-neohexaose	1434:1451	lacto-N-neohexaose	1434:1451	Difucosyllactose-N-hexaose b, 3'-sialyllactose and lacto-N-neohexaose were all detected at abundances >10% in feline milk samples.
33270789	11	67	located	detected	1462:1469	arg2	3'-sialyllactose					1413:1428	3'-sialyllactose	1413:1428	3'-sialyllactose	1413:1428	Difucosyllactose-N-hexaose b, 3'-sialyllactose and lacto-N-neohexaose were all detected at abundances >10% in feline milk samples.
33270789	11	67	located	detected	1462:1469	arg1	%					1488:1488	abundances >10%	1474:1488	abundances >10%	1474:1488	Difucosyllactose-N-hexaose b, 3'-sialyllactose and lacto-N-neohexaose were all detected at abundances >10% in feline milk samples.
33270789	11	67	located	detected	1462:1469	arg2	b					1410:1410	Difucosyllactose-N-hexaose b	1383:1410	Difucosyllactose-N-hexaose b	1383:1410	Difucosyllactose-N-hexaose b, 3'-sialyllactose and lacto-N-neohexaose were all detected at abundances >10% in feline milk samples.
33270789	10	68	theme	total	1376:1380	arg1	%					1367:1367	relative abundance >1%	1346:1367	relative abundance >1% of the total	1346:1380	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	10	68	theme	total	1376:1380	arg1	total					1376:1380	total	1376:1380	total	1376:1380	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	1	69	theme	pathogen	250:257	arg1	colonization					259:270	pathogen colonization	250:270	pathogen colonization	250:270	Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates.
33270789	0	70	theme	canine	76:81	arg1	profiles					64:71	unique oligosaccharide profiles	41:71	unique oligosaccharide profiles of canine and feline milk samples	41:105	High-throughput glycomic analyses reveal unique oligosaccharide profiles of canine and feline milk samples.
33270789	10	71	attach	present	1335:1341	arg2	structures					1324:1333	up to 16 structures	1315:1333	up to 16 structures present at relative abundance >1% of the total	1315:1380	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	10	71	attach	present	1335:1341	arg1	%					1367:1367	relative abundance >1%	1346:1367	relative abundance >1% of the total	1346:1380	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	10	71	attach	present	1335:1341	arg1	total					1376:1380	total	1376:1380	total	1376:1380	In feline samples, a more diverse range of oligosaccharides was detected, with up to 16 structures present at relative abundance >1% of the total.
33270789	12	72	theme	collection	1613:1622	arg1	points					1629:1634	collection time points	1613:1634	collection time points	1613:1634	Statistically significant differences (p<0.05) in oligosaccharide abundances were observed between collection time points and between diet groups within species.
33270789	7	73	theme	chromatography-mass	1007:1025	arg1	LC-MS					1041:1045	LC-MS	1041:1045	LC-MS	1041:1045	Following extraction, oligosaccharide content was determined by liquid chromatography-mass spectrometry (LC-MS).
33270789	7	73	theme	chromatography-mass	1007:1025	arg1	spectrometry					1027:1038	liquid chromatography-mass spectrometry	1000:1038	liquid chromatography-mass spectrometry (LC-MS)	1000:1046	Following extraction, oligosaccharide content was determined by liquid chromatography-mass spectrometry (LC-MS).
33270789	2	74	theme	samples	394:400	arg1	composition					356:366	Nutrient composition	347:366	Nutrient composition of canine and feline milk samples	347:400	Nutrient composition of canine and feline milk samples has been described previously, but little is known about the oligosaccharide content.
33270789	4	75	theme	shorthair	724:732	arg1	cats					734:737	6 domestic shorthair cats	713:737	6 domestic shorthair cats	713:737	23 dogs (9 Labrador retriever and 14 Labrador retriever x golden retriever crossbreed) and 6 domestic shorthair cats were recruited to the study.
35027133	0	0	theme	activity	89:96	arg1	improvement					60:70	improvement	60:70	improvement of antibacterial activity	60:96	Characteristics of chitosan fiber and their effects towards improvement of antibacterial activity.
35027133	2	1	from	degree	417:422	arg1	Mw					405:406	Mw	405:406	Mw	405:406	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	2	1	from	degree	417:422	arg1	weight					397:402	the molecular weight	383:402	the molecular weight (Mw)	383:407	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	3	2	theme	antibacterial	487:499	arg1	activity					501:508	antibacterial activity	487:508	antibacterial activity	487:508	On that basis, the relationship between antibacterial activity and Mw and DD can be established.
35027133	4	3	theme	antibacterial	557:569	arg1	mechanism					571:579	the antibacterial mechanism	553:579	the antibacterial mechanism of chitosan fiber	553:597	Finally, the antibacterial mechanism of chitosan fiber was obtained.
35027133	0	4	theme	antibacterial	75:87	arg1	activity					89:96	antibacterial activity	75:96	antibacterial activity	75:96	Characteristics of chitosan fiber and their effects towards improvement of antibacterial activity.
35027133	5	5	theme	inhibition	639:648	arg1	rate					650:653	the inhibition rate	635:653	the inhibition rate of samples I, K, L, and M against Staphylococcus aureus	635:709	The results show that the inhibition rate of samples I, K, L, and M against Staphylococcus aureus first increased and then decreased with the increase of Mw, and their bactericidal activity against Escherichia coli decreased with the increase of Mw when the DD was similar.
35027133	2	6	theme	Candida	344:350	arg1	albicans					352:359	Candida albicans	344:359	Candida albicans	344:359	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	6	7	theme	activity	1105:1112	arg1	enhancement					1076:1086	the enhancement	1072:1086	the enhancement of antibacterial activity and application in antibacterial textiles	1072:1154	This study provides an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles.
35027133	6	8	from	textiles	1147:1154	arg1	enhancement					1076:1086	the enhancement	1072:1086	the enhancement of antibacterial activity and application in antibacterial textiles	1072:1154	This study provides an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles.
35027133	5	9	dep	samples	658:664	arg1	I					666:666	I	666:666	I	666:666	The results show that the inhibition rate of samples I, K, L, and M against Staphylococcus aureus first increased and then decreased with the increase of Mw, and their bactericidal activity against Escherichia coli decreased with the increase of Mw when the DD was similar.
35027133	5	9	dep	samples	658:664	arg1	L					672:672	L	672:672	L	672:672	The results show that the inhibition rate of samples I, K, L, and M against Staphylococcus aureus first increased and then decreased with the increase of Mw, and their bactericidal activity against Escherichia coli decreased with the increase of Mw when the DD was similar.
35027133	5	9	dep	samples	658:664	arg1	M					679:679	M	679:679	M	679:679	The results show that the inhibition rate of samples I, K, L, and M against Staphylococcus aureus first increased and then decreased with the increase of Mw, and their bactericidal activity against Escherichia coli decreased with the increase of Mw when the DD was similar.
35027133	5	9	dep	samples	658:664	arg1	K					669:669	K	669:669	K	669:669	The results show that the inhibition rate of samples I, K, L, and M against Staphylococcus aureus first increased and then decreased with the increase of Mw, and their bactericidal activity against Escherichia coli decreased with the increase of Mw when the DD was similar.
35027133	5	9	dep	samples	658:664	arg1	samples					658:664	samples I, K, L, and M	658:679	samples I, K, L, and M	658:679	The results show that the inhibition rate of samples I, K, L, and M against Staphylococcus aureus first increased and then decreased with the increase of Mw, and their bactericidal activity against Escherichia coli decreased with the increase of Mw when the DD was similar.
35027133	6	10	theme	structural	1033:1042	arg1	parameters					1044:1053	structural parameters	1033:1053	structural parameters	1033:1053	This study provides an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles.
35027133	2	11	from	dependence	369:378	arg1	Mw					405:406	Mw	405:406	Mw	405:406	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	2	11	from	dependence	369:378	arg1	weight					397:402	the molecular weight	383:402	the molecular weight (Mw)	383:407	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	6	12	theme	antibacterial	1133:1145	arg1	textiles					1147:1154	antibacterial textiles	1133:1154	antibacterial textiles	1133:1154	This study provides an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles.
35027133	6	13	theme	effective	910:918	arg1	strategy					920:927	an effective strategy	907:927	an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles	907:1154	This study provides an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles.
35027133	6	14	from	application	1118:1128	arg1	textiles					1147:1154	antibacterial textiles	1133:1154	antibacterial textiles	1133:1154	This study provides an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles.
35027133	1	15	theme	surface	189:195	arg1	morphology					197:206	surface morphology	189:206	surface morphology	189:206	We selected eight kinds of chitosan fibers to characterize and analyze their composition, surface morphology, and mechanical properties.
35027133	0	16	theme	fiber	28:32	arg1	Characteristics					0:14	Characteristics	0:14	Characteristics of chitosan fiber	0:32	Characteristics of chitosan fiber and their effects towards improvement of antibacterial activity.
35027133	0	16	theme	fiber	28:32	arg1	effects					44:50	their effects	38:50	their effects towards improvement of antibacterial activity	38:96	Characteristics of chitosan fiber and their effects towards improvement of antibacterial activity.
35027133	6	17	theme	application	1118:1128	arg1	enhancement					1076:1086	the enhancement	1072:1086	the enhancement of antibacterial activity and application in antibacterial textiles	1072:1154	This study provides an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles.
35027133	6	18	theme	antibacterial	1006:1018	arg1	property					1020:1027	antibacterial property	1006:1027	antibacterial property	1006:1027	This study provides an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles.
35027133	2	19	theme	deacetylation	427:439	arg1	DD					442:443	DD	442:443	DD	442:443	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	2	19	theme	deacetylation	427:439	arg1	activity					283:290	their antibacterial activity	263:290	their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans	263:359	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	2	19	theme	deacetylation	427:439	arg1	degree					417:422	the degree	413:422	the degree of deacetylation	413:439	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	2	19	theme	deacetylation	427:439	arg1	dependence					369:378	the dependence	365:378	the dependence on the molecular weight (Mw)	365:407	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	5	20	theme	bactericidal	781:792	arg1	activity					794:801	their bactericidal activity	775:801	their bactericidal activity against Escherichia coli	775:826	The results show that the inhibition rate of samples I, K, L, and M against Staphylococcus aureus first increased and then decreased with the increase of Mw, and their bactericidal activity against Escherichia coli decreased with the increase of Mw when the DD was similar.
35027133	5	21	theme	Mw	767:768	arg1	increase					755:762	the increase	751:762	the increase of Mw	751:768	The results show that the inhibition rate of samples I, K, L, and M against Staphylococcus aureus first increased and then decreased with the increase of Mw, and their bactericidal activity against Escherichia coli decreased with the increase of Mw when the DD was similar.
35027133	1	22	theme	mechanical	213:222	arg1	properties					224:233	mechanical properties	213:233	mechanical properties	213:233	We selected eight kinds of chitosan fibers to characterize and analyze their composition, surface morphology, and mechanical properties.
35027133	6	23	from	enhancement	1076:1086	arg1	textiles					1147:1154	antibacterial textiles	1133:1154	antibacterial textiles	1133:1154	This study provides an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles.
35027133	5	24	theme	Mw	859:860	arg1	increase					847:854	the increase	843:854	the increase of Mw	843:860	The results show that the inhibition rate of samples I, K, L, and M against Staphylococcus aureus first increased and then decreased with the increase of Mw, and their bactericidal activity against Escherichia coli decreased with the increase of Mw when the DD was similar.
35027133	5	25	theme	samples	658:664	arg1	rate					650:653	the inhibition rate	635:653	the inhibition rate of samples I, K, L, and M against Staphylococcus aureus	635:709	The results show that the inhibition rate of samples I, K, L, and M against Staphylococcus aureus first increased and then decreased with the increase of Mw, and their bactericidal activity against Escherichia coli decreased with the increase of Mw when the DD was similar.
35027133	6	26	from	activity	1105:1112	arg1	textiles					1147:1154	antibacterial textiles	1133:1154	antibacterial textiles	1133:1154	This study provides an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles.
35027133	6	27	theme	antibacterial	1091:1103	arg1	activity					1105:1112	antibacterial activity	1091:1112	antibacterial activity	1091:1112	This study provides an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles.
35027133	2	28	theme	antibacterial	269:281	arg1	activity					283:290	their antibacterial activity	263:290	their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans	263:359	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	1	29	theme	chitosan	126:133	arg1	fibers					135:140	chitosan fibers	126:140	chitosan fibers	126:140	We selected eight kinds of chitosan fibers to characterize and analyze their composition, surface morphology, and mechanical properties.
35027133	2	30	from	activity	283:290	arg1	Mw					405:406	Mw	405:406	Mw	405:406	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	2	30	from	activity	283:290	arg1	weight					397:402	the molecular weight	383:402	the molecular weight (Mw)	383:407	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	4	31	theme	fiber	593:597	arg1	mechanism					571:579	the antibacterial mechanism	553:579	the antibacterial mechanism of chitosan fiber	553:597	Finally, the antibacterial mechanism of chitosan fiber was obtained.
35027133	1	32	theme	fibers	135:140	arg1	kinds					117:121	eight kinds	111:121	eight kinds of chitosan fibers	111:140	We selected eight kinds of chitosan fibers to characterize and analyze their composition, surface morphology, and mechanical properties.
35027133	4	33	theme	chitosan	584:591	arg1	fiber					593:597	chitosan fiber	584:597	chitosan fiber	584:597	Finally, the antibacterial mechanism of chitosan fiber was obtained.
35027133	6	34	theme	resultant	975:983	arg1	relationship					985:996	the resultant relationship	971:996	the resultant relationship between antibacterial property and structural parameters	971:1053	This study provides an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles.
35027133	2	35	theme	molecular	387:395	arg1	Mw					405:406	Mw	405:406	Mw	405:406	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	2	35	theme	molecular	387:395	arg1	weight					397:402	the molecular weight	383:402	the molecular weight (Mw)	383:407	Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD).
35027133	0	36	theme	chitosan	19:26	arg1	fiber					28:32	chitosan fiber	19:32	chitosan fiber	19:32	Characteristics of chitosan fiber and their effects towards improvement of antibacterial activity.
35027133	6	37	theme	chitosan	952:959	arg1	fiber					961:965	the chitosan fiber	948:965	the chitosan fiber	948:965	This study provides an effective strategy for characterizing the chitosan fiber and the resultant relationship between antibacterial property and structural parameters that may benefit the enhancement of antibacterial activity and application in antibacterial textiles.
33141346	12	0	theme	light	1376:1380	arg1	microscopy					1382:1391	light microscopy	1376:1391	light microscopy of skin sections following turgor release	1376:1433	This was indexed by light microscopy of skin sections following turgor release, and by determinations of the swelling capacity, water holding capacity and water retention capacity.
33141346	11	1	theme	development	1312:1322	arg1	stages					1287:1292	stages I and II	1287:1301	stages	1287:1292	Cell wall swelling increases during stages I and II of fruit development, with little change thereafter.
33141346	7	2	theme	fruit	716:720	arg1	development					722:732	fruit development	716:732	fruit development	716:732	During fruit development, total mass of cell wall, of pectins and of hemicelluloses increases, but total mass of cellulose remains constant.
33141346	9	3	theme	NaOH-soluble	1116:1127	arg1	fraction					1136:1143	the NaOH-soluble pectin fraction	1112:1143	the NaOH-soluble pectin fraction	1112:1143	During stage III, on a whole-fruit basis, the HCl-soluble pectin fraction, followed by the water-soluble pectin fraction, the NaOH-soluble pectin fraction and the oxalate-soluble pectin fraction all increase.
33141346	8	4	theme	fresh	929:933	arg1	mass-particularly					935:951	the fruit fresh mass-particularly	919:951	the fruit fresh mass-particularly	919:951	The mass of these cell wall fractions increases at a lower rate than the fruit fresh mass-particularly during stage II and early stage III.
33141346	15	5	theme	alcohol-insoluble	1753:1769	arg1	residue					1771:1777	the alcohol-insoluble residue	1749:1777	the alcohol-insoluble residue	1749:1777	The swelling pressure of the alcohol-insoluble residue is low throughout development and surprisingly similar across different cell wall fractions.
33141346	7	6	theme	total	808:812	arg1	mass					814:817	total mass	808:817	total mass of cellulose	808:830	During fruit development, total mass of cell wall, of pectins and of hemicelluloses increases, but total mass of cellulose remains constant.
33141346	1	7	theme	deposition	176:185	arg1	rate					187:190	cell wall deposition rate	166:190	cell wall deposition rate	166:190	During fruit development, cell wall deposition rate decreases and cell wall swelling increases.
33141346	13	8	from	increases	1612:1620	arg1	pectins					1638:1644	NaOH-soluble pectins	1625:1644	NaOH-soluble pectins	1625:1644	The increase in cell wall swelling during development was due primarily to increases in NaOH-soluble pectins.
33141346	15	9	theme	wall	1856:1859	arg1	fractions					1861:1869	different cell wall fractions	1841:1869	different cell wall fractions	1841:1869	The swelling pressure of the alcohol-insoluble residue is low throughout development and surprisingly similar across different cell wall fractions.
33141346	0	10	theme	cherry	126:131	arg1	fruit					133:137	sweet cherry fruit	120:137	sweet cherry fruit	120:137	Decreased deposition and increased swelling of cell walls contribute to increased cracking susceptibility of developing sweet cherry fruit.
33141346	9	11	theme	pectin	1169:1174	arg1	fraction					1176:1183	the oxalate-soluble pectin fraction	1149:1183	the oxalate-soluble pectin fraction	1149:1183	During stage III, on a whole-fruit basis, the HCl-soluble pectin fraction, followed by the water-soluble pectin fraction, the NaOH-soluble pectin fraction and the oxalate-soluble pectin fraction all increase.
33141346	7	12	theme	hemicelluloses	778:791	arg1	mass					741:744	total mass	735:744	total mass of cell wall, of pectins and of hemicelluloses	735:791	During fruit development, total mass of cell wall, of pectins and of hemicelluloses increases, but total mass of cellulose remains constant.
33141346	1	13	theme	cell	206:209	arg1	swelling					216:223	cell wall swelling	206:223	cell wall swelling	206:223	During fruit development, cell wall deposition rate decreases and cell wall swelling increases.
33141346	4	14	theme	Cell	422:425	arg1	swelling					432:439	Cell wall swelling	422:439	Cell wall swelling	422:439	Cell wall swelling decreases both the cell: cell adhesion and the cell wall fracture force.
33141346	15	15	theme	different	1841:1849	arg1	fractions					1861:1869	different cell wall fractions	1841:1869	different cell wall fractions	1841:1869	The swelling pressure of the alcohol-insoluble residue is low throughout development and surprisingly similar across different cell wall fractions.
33141346	1	16	theme	swelling	216:223	arg1	increases					225:233	and cell wall swelling increases	202:233	increases	225:233	During fruit development, cell wall deposition rate decreases and cell wall swelling increases.
33141346	12	17	theme	retention	1517:1525	arg1	capacity					1527:1534	water retention capacity	1511:1534	water retention capacity	1511:1534	This was indexed by light microscopy of skin sections following turgor release, and by determinations of the swelling capacity, water holding capacity and water retention capacity.
33141346	6	18	theme	wall	639:642	arg1	swelling					644:651	cell wall swelling	634:651	cell wall swelling	634:651	The objectives were to relate developmental changes in cell wall swelling to compositional changes taking place in the cell wall.
33141346	6	19	from	changes	623:629	arg1	swelling					644:651	cell wall swelling	634:651	cell wall swelling	634:651	The objectives were to relate developmental changes in cell wall swelling to compositional changes taking place in the cell wall.
33141346	2	20	theme	wall	245:248	arg1	pressure					259:266	The cell wall swelling pressure	236:266	The cell wall swelling pressure	236:266	The cell wall swelling pressure is very low relative to the fruit's highly negative osmotic potential.
33141346	2	20	theme	wall	245:248	arg1	low					276:278	low	276:278	low	276:278	The cell wall swelling pressure is very low relative to the fruit's highly negative osmotic potential.
33141346	12	21	theme	holding	1490:1496	arg1	capacity					1498:1505	water holding capacity	1484:1505	water holding capacity	1484:1505	This was indexed by light microscopy of skin sections following turgor release, and by determinations of the swelling capacity, water holding capacity and water retention capacity.
33141346	4	22	theme	cell	466:469	arg1	adhesion					471:478	the cell: cell adhesion	456:478	the cell: cell adhesion	456:478	Cell wall swelling decreases both the cell: cell adhesion and the cell wall fracture force.
33141346	6	23	theme	developmental	609:621	arg1	changes					623:629	developmental changes	609:629	developmental changes in cell wall swelling	609:651	The objectives were to relate developmental changes in cell wall swelling to compositional changes taking place in the cell wall.
33141346	8	24	theme	early	973:977	arg1	stage					979:983	early stage III	973:987	early stage III	973:987	The mass of these cell wall fractions increases at a lower rate than the fruit fresh mass-particularly during stage II and early stage III.
33141346	1	25	theme	cell	166:169	arg1	rate					187:190	cell wall deposition rate	166:190	cell wall deposition rate	166:190	During fruit development, cell wall deposition rate decreases and cell wall swelling increases.
33141346	9	26	theme	HCl-soluble	1036:1046	arg1	fraction					1055:1062	the HCl-soluble pectin fraction	1032:1062	the HCl-soluble pectin fraction	1032:1062	During stage III, on a whole-fruit basis, the HCl-soluble pectin fraction, followed by the water-soluble pectin fraction, the NaOH-soluble pectin fraction and the oxalate-soluble pectin fraction all increase.
33141346	12	27	theme	swelling	1465:1472	arg1	capacity					1474:1481	the swelling capacity	1461:1481	the swelling capacity	1461:1481	This was indexed by light microscopy of skin sections following turgor release, and by determinations of the swelling capacity, water holding capacity and water retention capacity.
33141346	11	28	theme	Cell	1251:1254	arg1	swelling					1261:1268	Cell wall swelling	1251:1268	Cell wall swelling	1251:1268	Cell wall swelling increases during stages I and II of fruit development, with little change thereafter.
33141346	10	29	theme	HCl-soluble	1221:1231	arg1	pectin					1233:1238	just the HCl-soluble pectin	1212:1238	just the HCl-soluble pectin	1212:1238	At maturity, just the HCl-soluble pectin decreases.
33141346	3	30	theme	walls	415:419	arg1	swelling					394:401	the swelling	390:401	the swelling of the cell walls	390:419	Rain cracking of sweet cherry fruit is preceded by the swelling of the cell walls.
33141346	16	31	theme	water	1939:1943	arg1	potential					1945:1953	fruit water potential	1933:1953	fruit water potential	1933:1953	Thus, swelling pressure does not contribute significantly to fruit water potential.
33141346	4	32	theme	cell	460:463	arg1	adhesion					471:478	the cell: cell adhesion	456:478	the cell: cell adhesion	456:478	Cell wall swelling decreases both the cell: cell adhesion and the cell wall fracture force.
33141346	15	33	theme	swelling	1728:1735	arg1	pressure					1737:1744	The swelling pressure	1724:1744	The swelling pressure of the alcohol-insoluble residue	1724:1777	The swelling pressure of the alcohol-insoluble residue is low throughout development and surprisingly similar across different cell wall fractions.
33141346	15	33	theme	swelling	1728:1735	arg1	low					1782:1784	low	1782:1784	low	1782:1784	The swelling pressure of the alcohol-insoluble residue is low throughout development and surprisingly similar across different cell wall fractions.
33141346	0	34	theme	Decreased	0:8	arg1	deposition					10:19	Decreased deposition	0:19	Decreased deposition	0:19	Decreased deposition and increased swelling of cell walls contribute to increased cracking susceptibility of developing sweet cherry fruit.
33141346	5	35	theme	fruit	560:564	arg1	development					566:576	fruit development	560:576	fruit development	560:576	Rain cracking susceptibility increases during fruit development.
33141346	3	36	theme	cherry	362:367	arg1	fruit					369:373	sweet cherry fruit	356:373	sweet cherry fruit	356:373	Rain cracking of sweet cherry fruit is preceded by the swelling of the cell walls.
33141346	8	37	theme	cell	868:871	arg1	fractions					878:886	these cell wall fractions	862:886	these cell wall fractions	862:886	The mass of these cell wall fractions increases at a lower rate than the fruit fresh mass-particularly during stage II and early stage III.
33141346	9	38	theme	pectin	1048:1053	arg1	fraction					1055:1062	the HCl-soluble pectin fraction	1032:1062	the HCl-soluble pectin fraction	1032:1062	During stage III, on a whole-fruit basis, the HCl-soluble pectin fraction, followed by the water-soluble pectin fraction, the NaOH-soluble pectin fraction and the oxalate-soluble pectin fraction all increase.
33141346	7	39	theme	wall	754:757	arg1	mass					741:744	total mass	735:744	total mass of cell wall, of pectins and of hemicelluloses	735:791	During fruit development, total mass of cell wall, of pectins and of hemicelluloses increases, but total mass of cellulose remains constant.
33141346	8	40	theme	fractions	878:886	arg1	mass					854:857	The mass	850:857	The mass of these cell wall fractions	850:886	The mass of these cell wall fractions increases at a lower rate than the fruit fresh mass-particularly during stage II and early stage III.
33141346	4	41	theme	cell	488:491	arg1	force					507:511	the cell wall fracture force	484:511	the cell wall fracture force	484:511	Cell wall swelling decreases both the cell: cell adhesion and the cell wall fracture force.
33141346	13	42	theme	cell	1553:1556	arg1	swelling					1563:1570	cell wall swelling	1553:1570	cell wall swelling	1553:1570	The increase in cell wall swelling during development was due primarily to increases in NaOH-soluble pectins.
33141346	0	43	theme	cell	47:50	arg1	walls					52:56	cell walls	47:56	cell walls	47:56	Decreased deposition and increased swelling of cell walls contribute to increased cracking susceptibility of developing sweet cherry fruit.
33141346	14	44	theme	applied	1706:1712	arg1	pressure					1714:1721	the applied pressure	1702:1721	the applied pressure	1702:1721	The in vitro swelling of cell wall extracts depends on the applied pressure.
33141346	16	45	theme	swelling	1878:1885	arg1	pressure					1887:1894	swelling pressure	1878:1894	swelling pressure	1878:1894	Thus, swelling pressure does not contribute significantly to fruit water potential.
33141346	4	46	theme	fracture	498:505	arg1	force					507:511	the cell wall fracture force	484:511	the cell wall fracture force	484:511	Cell wall swelling decreases both the cell: cell adhesion and the cell wall fracture force.
33141346	2	47	theme	osmotic	320:326	arg1	potential					328:336	the fruit's highly negative osmotic potential	292:336	the fruit's highly negative osmotic potential	292:336	The cell wall swelling pressure is very low relative to the fruit's highly negative osmotic potential.
33141346	7	48	theme	total	735:739	arg1	mass					741:744	total mass	735:744	total mass of cell wall, of pectins and of hemicelluloses	735:791	During fruit development, total mass of cell wall, of pectins and of hemicelluloses increases, but total mass of cellulose remains constant.
33141346	8	49	theme	lower	903:907	arg1	rate					909:912	a lower rate	901:912	a lower rate than the fruit fresh mass-particularly	901:951	The mass of these cell wall fractions increases at a lower rate than the fruit fresh mass-particularly during stage II and early stage III.
33141346	9	50	theme	water-soluble	1081:1093	arg1	fraction					1102:1109	the water-soluble pectin fraction	1077:1109	the water-soluble pectin fraction	1077:1109	During stage III, on a whole-fruit basis, the HCl-soluble pectin fraction, followed by the water-soluble pectin fraction, the NaOH-soluble pectin fraction and the oxalate-soluble pectin fraction all increase.
33141346	14	51	theme	extracts	1682:1689	arg1	swelling					1660:1667	The in vitro swelling	1647:1667	The in vitro swelling of cell wall extracts	1647:1689	The in vitro swelling of cell wall extracts depends on the applied pressure.
33141346	13	52	from	increase	1541:1548	arg1	swelling					1563:1570	cell wall swelling	1553:1570	cell wall swelling	1553:1570	The increase in cell wall swelling during development was due primarily to increases in NaOH-soluble pectins.
33141346	11	53	theme	fruit	1306:1310	arg1	development					1312:1322	fruit development	1306:1322	fruit development	1306:1322	Cell wall swelling increases during stages I and II of fruit development, with little change thereafter.
33141346	14	54	theme	cell	1672:1675	arg1	extracts					1682:1689	cell wall extracts	1672:1689	cell wall extracts	1672:1689	The in vitro swelling of cell wall extracts depends on the applied pressure.
33141346	12	55	theme	skin	1396:1399	arg1	sections					1401:1408	skin sections	1396:1408	skin sections following turgor release	1396:1433	This was indexed by light microscopy of skin sections following turgor release, and by determinations of the swelling capacity, water holding capacity and water retention capacity.
33141346	8	56	theme	fruit	923:927	arg1	mass-particularly					935:951	the fruit fresh mass-particularly	919:951	the fruit fresh mass-particularly	919:951	The mass of these cell wall fractions increases at a lower rate than the fruit fresh mass-particularly during stage II and early stage III.
33141346	15	57	theme	residue	1771:1777	arg1	pressure					1737:1744	The swelling pressure	1724:1744	The swelling pressure of the alcohol-insoluble residue	1724:1777	The swelling pressure of the alcohol-insoluble residue is low throughout development and surprisingly similar across different cell wall fractions.
33141346	15	57	theme	residue	1771:1777	arg1	low					1782:1784	low	1782:1784	low	1782:1784	The swelling pressure of the alcohol-insoluble residue is low throughout development and surprisingly similar across different cell wall fractions.
33141346	11	58	theme	little	1330:1335	arg1	change					1337:1342	little change	1330:1342	little change thereafter	1330:1353	Cell wall swelling increases during stages I and II of fruit development, with little change thereafter.
33141346	9	59	theme	pectin	1129:1134	arg1	fraction					1136:1143	the NaOH-soluble pectin fraction	1112:1143	the NaOH-soluble pectin fraction	1112:1143	During stage III, on a whole-fruit basis, the HCl-soluble pectin fraction, followed by the water-soluble pectin fraction, the NaOH-soluble pectin fraction and the oxalate-soluble pectin fraction all increase.
33141346	7	60	theme	cellulose	822:830	arg1	mass					814:817	total mass	808:817	total mass of cellulose	808:830	During fruit development, total mass of cell wall, of pectins and of hemicelluloses increases, but total mass of cellulose remains constant.
33141346	1	61	theme	wall	171:174	arg1	rate					187:190	cell wall deposition rate	166:190	cell wall deposition rate	166:190	During fruit development, cell wall deposition rate decreases and cell wall swelling increases.
33141346	15	62	theme	cell	1851:1854	arg1	fractions					1861:1869	different cell wall fractions	1841:1869	different cell wall fractions	1841:1869	The swelling pressure of the alcohol-insoluble residue is low throughout development and surprisingly similar across different cell wall fractions.
33141346	9	63	theme	oxalate-soluble	1153:1167	arg1	fraction					1176:1183	the oxalate-soluble pectin fraction	1149:1183	the oxalate-soluble pectin fraction	1149:1183	During stage III, on a whole-fruit basis, the HCl-soluble pectin fraction, followed by the water-soluble pectin fraction, the NaOH-soluble pectin fraction and the oxalate-soluble pectin fraction all increase.
33141346	4	64	theme	wall	427:430	arg1	swelling					432:439	Cell wall swelling	422:439	Cell wall swelling	422:439	Cell wall swelling decreases both the cell: cell adhesion and the cell wall fracture force.
33141346	2	65	theme	cell	240:243	arg1	pressure					259:266	The cell wall swelling pressure	236:266	The cell wall swelling pressure	236:266	The cell wall swelling pressure is very low relative to the fruit's highly negative osmotic potential.
33141346	2	65	theme	cell	240:243	arg1	low					276:278	low	276:278	low	276:278	The cell wall swelling pressure is very low relative to the fruit's highly negative osmotic potential.
33141346	1	66	theme	wall	211:214	arg1	swelling					216:223	cell wall swelling	206:223	cell wall swelling	206:223	During fruit development, cell wall deposition rate decreases and cell wall swelling increases.
33141346	12	67	theme	water	1511:1515	arg1	capacity					1527:1534	water retention capacity	1511:1534	water retention capacity	1511:1534	This was indexed by light microscopy of skin sections following turgor release, and by determinations of the swelling capacity, water holding capacity and water retention capacity.
33141346	12	68	theme	capacity	1527:1534	arg1	determinations					1443:1456	determinations	1443:1456	determinations of the swelling capacity, water holding capacity and water retention capacity	1443:1534	This was indexed by light microscopy of skin sections following turgor release, and by determinations of the swelling capacity, water holding capacity and water retention capacity.
33141346	12	69	theme	water	1484:1488	arg1	capacity					1498:1505	water holding capacity	1484:1505	water holding capacity	1484:1505	This was indexed by light microscopy of skin sections following turgor release, and by determinations of the swelling capacity, water holding capacity and water retention capacity.
33141346	6	70	theme	cell	634:637	arg1	swelling					644:651	cell wall swelling	634:651	cell wall swelling	634:651	The objectives were to relate developmental changes in cell wall swelling to compositional changes taking place in the cell wall.
33141346	2	71	theme	swelling	250:257	arg1	pressure					259:266	The cell wall swelling pressure	236:266	The cell wall swelling pressure	236:266	The cell wall swelling pressure is very low relative to the fruit's highly negative osmotic potential.
33141346	2	71	theme	swelling	250:257	arg1	low					276:278	low	276:278	low	276:278	The cell wall swelling pressure is very low relative to the fruit's highly negative osmotic potential.
33141346	1	72	theme	fruit	147:151	arg1	development					153:163	fruit development	147:163	fruit development	147:163	During fruit development, cell wall deposition rate decreases and cell wall swelling increases.
33141346	12	73	theme	capacity	1498:1505	arg1	determinations					1443:1456	determinations	1443:1456	determinations of the swelling capacity, water holding capacity and water retention capacity	1443:1534	This was indexed by light microscopy of skin sections following turgor release, and by determinations of the swelling capacity, water holding capacity and water retention capacity.
33141346	14	74	theme	in	1651:1652	arg1	swelling					1660:1667	The in vitro swelling	1647:1667	The in vitro swelling of cell wall extracts	1647:1689	The in vitro swelling of cell wall extracts depends on the applied pressure.
33141346	16	75	theme	fruit	1933:1937	arg1	potential					1945:1953	fruit water potential	1933:1953	fruit water potential	1933:1953	Thus, swelling pressure does not contribute significantly to fruit water potential.
33141346	12	76	theme	capacity	1474:1481	arg1	determinations					1443:1456	determinations	1443:1456	determinations of the swelling capacity, water holding capacity and water retention capacity	1443:1534	This was indexed by light microscopy of skin sections following turgor release, and by determinations of the swelling capacity, water holding capacity and water retention capacity.
33141346	3	77	theme	sweet	356:360	arg1	fruit					369:373	sweet cherry fruit	356:373	sweet cherry fruit	356:373	Rain cracking of sweet cherry fruit is preceded by the swelling of the cell walls.
33141346	6	78	theme	cell	698:701	arg1	wall					703:706	the cell wall	694:706	the cell wall	694:706	The objectives were to relate developmental changes in cell wall swelling to compositional changes taking place in the cell wall.
33141346	0	79	theme	sweet	120:124	arg1	fruit					133:137	sweet cherry fruit	120:137	sweet cherry fruit	120:137	Decreased deposition and increased swelling of cell walls contribute to increased cracking susceptibility of developing sweet cherry fruit.
33141346	3	80	theme	cracking	344:351	arg1	Rain					339:342	Rain cracking	339:351	Rain cracking of sweet cherry fruit	339:373	Rain cracking of sweet cherry fruit is preceded by the swelling of the cell walls.
33141346	11	81	theme	wall	1256:1259	arg1	swelling					1261:1268	Cell wall swelling	1251:1268	Cell wall swelling	1251:1268	Cell wall swelling increases during stages I and II of fruit development, with little change thereafter.
33141346	9	82	theme	whole-fruit	1013:1023	arg1	basis					1025:1029	a whole-fruit basis	1011:1029	a whole-fruit basis	1011:1029	During stage III, on a whole-fruit basis, the HCl-soluble pectin fraction, followed by the water-soluble pectin fraction, the NaOH-soluble pectin fraction and the oxalate-soluble pectin fraction all increase.
33141346	13	83	theme	NaOH-soluble	1625:1636	arg1	pectins					1638:1644	NaOH-soluble pectins	1625:1644	NaOH-soluble pectins	1625:1644	The increase in cell wall swelling during development was due primarily to increases in NaOH-soluble pectins.
33141346	3	84	theme	cell	410:413	arg1	walls					415:419	the cell walls	406:419	the cell walls	406:419	Rain cracking of sweet cherry fruit is preceded by the swelling of the cell walls.
33141346	0	85	theme	increased	25:33	arg1	swelling					35:42	increased swelling	25:42	increased swelling of cell walls	25:56	Decreased deposition and increased swelling of cell walls contribute to increased cracking susceptibility of developing sweet cherry fruit.
33141346	3	86	theme	fruit	369:373	arg1	Rain					339:342	Rain cracking	339:351	Rain cracking of sweet cherry fruit	339:373	Rain cracking of sweet cherry fruit is preceded by the swelling of the cell walls.
33141346	6	87	theme	compositional	656:668	arg1	changes					670:676	compositional changes	656:676	compositional changes taking place in the cell wall	656:706	The objectives were to relate developmental changes in cell wall swelling to compositional changes taking place in the cell wall.
33141346	7	88	theme	pectins	763:769	arg1	mass					741:744	total mass	735:744	total mass of cell wall, of pectins and of hemicelluloses	735:791	During fruit development, total mass of cell wall, of pectins and of hemicelluloses increases, but total mass of cellulose remains constant.
33141346	4	89	theme	wall	493:496	arg1	force					507:511	the cell wall fracture force	484:511	the cell wall fracture force	484:511	Cell wall swelling decreases both the cell: cell adhesion and the cell wall fracture force.
33141346	0	90	theme	walls	52:56	arg1	deposition					10:19	Decreased deposition	0:19	Decreased deposition	0:19	Decreased deposition and increased swelling of cell walls contribute to increased cracking susceptibility of developing sweet cherry fruit.
33141346	0	90	theme	walls	52:56	arg1	swelling					35:42	increased swelling	25:42	increased swelling of cell walls	25:56	Decreased deposition and increased swelling of cell walls contribute to increased cracking susceptibility of developing sweet cherry fruit.
33141346	8	91	theme	wall	873:876	arg1	fractions					878:886	these cell wall fractions	862:886	these cell wall fractions	862:886	The mass of these cell wall fractions increases at a lower rate than the fruit fresh mass-particularly during stage II and early stage III.
33141346	13	92	theme	wall	1558:1561	arg1	swelling					1563:1570	cell wall swelling	1553:1570	cell wall swelling	1553:1570	The increase in cell wall swelling during development was due primarily to increases in NaOH-soluble pectins.
33141346	7	93	theme	cell	749:752	arg1	wall					754:757	cell wall	749:757	cell wall	749:757	During fruit development, total mass of cell wall, of pectins and of hemicelluloses increases, but total mass of cellulose remains constant.
33141346	12	94	theme	sections	1401:1408	arg1	microscopy					1382:1391	light microscopy	1376:1391	light microscopy of skin sections following turgor release	1376:1433	This was indexed by light microscopy of skin sections following turgor release, and by determinations of the swelling capacity, water holding capacity and water retention capacity.
33141346	14	95	dep	in	1651:1652	arg1	vitro					1654:1658	vitro	1654:1658	vitro	1654:1658	The in vitro swelling of cell wall extracts depends on the applied pressure.
33141346	2	96	theme	negative	311:318	arg1	potential					328:336	the fruit's highly negative osmotic potential	292:336	the fruit's highly negative osmotic potential	292:336	The cell wall swelling pressure is very low relative to the fruit's highly negative osmotic potential.
33141346	12	97	theme	turgor	1420:1425	arg1	release					1427:1433	turgor release	1420:1433	turgor release	1420:1433	This was indexed by light microscopy of skin sections following turgor release, and by determinations of the swelling capacity, water holding capacity and water retention capacity.
33141346	9	98	theme	pectin	1095:1100	arg1	fraction					1102:1109	the water-soluble pectin fraction	1077:1109	the water-soluble pectin fraction	1077:1109	During stage III, on a whole-fruit basis, the HCl-soluble pectin fraction, followed by the water-soluble pectin fraction, the NaOH-soluble pectin fraction and the oxalate-soluble pectin fraction all increase.
33141346	14	99	theme	wall	1677:1680	arg1	extracts					1682:1689	cell wall extracts	1672:1689	cell wall extracts	1672:1689	The in vitro swelling of cell wall extracts depends on the applied pressure.
32657575	7	0	theme	flexographic	1161:1172	arg1	printing					1174:1181	an integrated roll-to-roll flexographic printing	1134:1181	an integrated roll-to-roll flexographic printing with rapid photonic annealing technique	1134:1221	Such an ultrasensitive VAG biosensor is suitable for low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique.
32657575	6	1	theme	local	1033:1037	arg1	water					1043:1047	local tap water	1033:1047	local tap water	1033:1047	The biosensor exhibited a limit of detection of 1.2 ng/L for microcystin-LR in local tap water.
32657575	3	2	theme	aligned	535:541	arg1	biosensors					558:567	vertically aligned graphene (VAG) biosensors	524:567	vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins	524:612	Herein, we report the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water.
32657575	3	3	from	use	422:424	arg1	cellulose					493:501	a flexographically printed graphene-ethyl cellulose	451:501	a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water	451:630	Herein, we report the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water.
32657575	7	4	theme	integrated	1137:1146	arg1	printing					1174:1181	an integrated roll-to-roll flexographic printing	1134:1181	an integrated roll-to-roll flexographic printing with rapid photonic annealing technique	1134:1221	Such an ultrasensitive VAG biosensor is suitable for low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique.
32657575	4	5	theme	intense	779:785	arg1	light					794:798	intense pulsed light	779:798	intense pulsed light	779:798	These VAG structures, which maximized the specific surface area of graphene, were formed by partial removal of the polymeric binder upon applying intense pulsed light on the printed graphene.
32657575	7	6	theme	roll-to-roll	1148:1159	arg1	printing					1174:1181	an integrated roll-to-roll flexographic printing	1134:1181	an integrated roll-to-roll flexographic printing with rapid photonic annealing technique	1134:1221	Such an ultrasensitive VAG biosensor is suitable for low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique.
32657575	7	7	theme	photonic	1194:1201	arg1	technique					1213:1221	rapid photonic annealing technique	1188:1221	rapid photonic annealing technique	1188:1221	Such an ultrasensitive VAG biosensor is suitable for low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique.
32657575	1	8	theme	chemical	144:151	arg1	properties					153:162	excellent physical, electronic, and chemical properties	108:162	excellent physical, electronic, and chemical properties that are highly desirable for biosensing applications	108:216	Graphene exhibits excellent physical, electronic, and chemical properties that are highly desirable for biosensing applications.
32657575	2	9	theme	surface	351:357	arg1	area					359:362	its maximum specific surface area	330:362	its maximum specific surface area for ultrasensitive detection	330:391	However, most graphene biosensors are based on graphene lying flat on a substrate and therefore do not utilize its maximum specific surface area for ultrasensitive detection.
32657575	5	10	theme	VAG	851:853	arg1	biosensor					855:863	A label-free and low-cost VAG biosensor	825:863	A label-free and low-cost VAG biosensor based on a non-faradaic electrochemical impedance spectroscopy technique	825:936	A label-free and low-cost VAG biosensor based on a non-faradaic electrochemical impedance spectroscopy technique was fabricated.
32657575	3	11	theme	VAG	553:555	arg1	biosensors					558:567	vertically aligned graphene (VAG) biosensors	524:567	vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins	524:612	Herein, we report the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water.
32657575	5	12	theme	non-faradaic	876:887	arg1	technique					928:936	a non-faradaic electrochemical impedance spectroscopy technique	874:936	a non-faradaic electrochemical impedance spectroscopy technique	874:936	A label-free and low-cost VAG biosensor based on a non-faradaic electrochemical impedance spectroscopy technique was fabricated.
32657575	3	13	theme	annealing	438:446	arg1	use					422:424	the novel use	412:424	the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water	412:630	Herein, we report the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water.
32657575	3	14	theme	novel	416:420	arg1	use					422:424	the novel use	412:424	the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water	412:630	Herein, we report the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water.
32657575	4	15	theme	pulsed	787:792	arg1	light					794:798	intense pulsed light	779:798	intense pulsed light	779:798	These VAG structures, which maximized the specific surface area of graphene, were formed by partial removal of the polymeric binder upon applying intense pulsed light on the printed graphene.
32657575	7	16	with	printing	1174:1181	arg1	technique					1213:1221	rapid photonic annealing technique	1188:1221	rapid photonic annealing technique	1188:1221	Such an ultrasensitive VAG biosensor is suitable for low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique.
32657575	4	17	theme	specific	675:682	arg1	area					692:695	the specific surface area	671:695	the specific surface area of graphene	671:707	These VAG structures, which maximized the specific surface area of graphene, were formed by partial removal of the polymeric binder upon applying intense pulsed light on the printed graphene.
32657575	0	18	theme	Aligned	11:17	arg1	Graphene					19:26	Vertically Aligned Graphene	0:26	Vertically Aligned Graphene	0:26	Vertically Aligned Graphene Prepared by Photonic Annealing for Ultrasensitive Biosensors.
32657575	7	19	theme	mass	1112:1115	arg1	production					1117:1126	low-cost mass production	1103:1126	low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique	1103:1221	Such an ultrasensitive VAG biosensor is suitable for low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique.
32657575	4	20	theme	polymeric	748:756	arg1	binder					758:763	the polymeric binder	744:763	the polymeric binder	744:763	These VAG structures, which maximized the specific surface area of graphene, were formed by partial removal of the polymeric binder upon applying intense pulsed light on the printed graphene.
32657575	1	21	theme	biosensing	194:203	arg1	applications					205:216	biosensing applications	194:216	biosensing applications	194:216	Graphene exhibits excellent physical, electronic, and chemical properties that are highly desirable for biosensing applications.
32657575	6	22	theme	ng/L	1006:1009	arg1	detection					989:997	detection	989:997	detection of 1.2 ng/L	989:1009	The biosensor exhibited a limit of detection of 1.2 ng/L for microcystin-LR in local tap water.
32657575	1	23	theme	excellent	108:116	arg1	properties					153:162	excellent physical, electronic, and chemical properties	108:162	excellent physical, electronic, and chemical properties that are highly desirable for biosensing applications	108:216	Graphene exhibits excellent physical, electronic, and chemical properties that are highly desirable for biosensing applications.
32657575	3	24	theme	photonic	429:436	arg1	annealing					438:446	photonic annealing	429:446	photonic annealing	429:446	Herein, we report the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water.
32657575	5	25	theme	label-free	827:836	arg1	biosensor					855:863	A label-free and low-cost VAG biosensor	825:863	A label-free and low-cost VAG biosensor based on a non-faradaic electrochemical impedance spectroscopy technique	825:936	A label-free and low-cost VAG biosensor based on a non-faradaic electrochemical impedance spectroscopy technique was fabricated.
32657575	1	26	theme	physical	118:125	arg1	properties					153:162	excellent physical, electronic, and chemical properties	108:162	excellent physical, electronic, and chemical properties that are highly desirable for biosensing applications	108:216	Graphene exhibits excellent physical, electronic, and chemical properties that are highly desirable for biosensing applications.
32657575	3	27	theme	printed	470:476	arg1	cellulose					493:501	a flexographically printed graphene-ethyl cellulose	451:501	a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water	451:630	Herein, we report the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water.
32657575	3	28	theme	algal	601:605	arg1	toxins					607:612	algal toxins	601:612	algal toxins	601:612	Herein, we report the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water.
32657575	7	29	theme	low-cost	1103:1110	arg1	production					1117:1126	low-cost mass production	1103:1126	low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique	1103:1221	Such an ultrasensitive VAG biosensor is suitable for low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique.
32657575	4	30	theme	binder	758:763	arg1	removal					733:739	partial removal	725:739	partial removal of the polymeric binder	725:763	These VAG structures, which maximized the specific surface area of graphene, were formed by partial removal of the polymeric binder upon applying intense pulsed light on the printed graphene.
32657575	3	31	theme	graphene-ethyl	478:491	arg1	cellulose					493:501	a flexographically printed graphene-ethyl cellulose	451:501	a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water	451:630	Herein, we report the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water.
32657575	0	32	theme	Photonic	40:47	arg1	Annealing					49:57	Photonic Annealing	40:57	Photonic Annealing for Ultrasensitive Biosensors	40:87	Vertically Aligned Graphene Prepared by Photonic Annealing for Ultrasensitive Biosensors.
32657575	6	33	theme	detection	989:997	arg1	limit					980:984	a limit	978:984	a limit of detection of 1.2 ng/L for microcystin-LR	978:1028	The biosensor exhibited a limit of detection of 1.2 ng/L for microcystin-LR in local tap water.
32657575	5	34	theme	electrochemical	889:903	arg1	technique					928:936	a non-faradaic electrochemical impedance spectroscopy technique	874:936	a non-faradaic electrochemical impedance spectroscopy technique	874:936	A label-free and low-cost VAG biosensor based on a non-faradaic electrochemical impedance spectroscopy technique was fabricated.
32657575	4	35	theme	surface	684:690	arg1	area					692:695	the specific surface area	671:695	the specific surface area of graphene	671:707	These VAG structures, which maximized the specific surface area of graphene, were formed by partial removal of the polymeric binder upon applying intense pulsed light on the printed graphene.
32657575	7	36	theme	annealing	1203:1211	arg1	technique					1213:1221	rapid photonic annealing technique	1188:1221	rapid photonic annealing technique	1188:1221	Such an ultrasensitive VAG biosensor is suitable for low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique.
32657575	6	37	theme	tap	1039:1041	arg1	water					1043:1047	local tap water	1033:1047	local tap water	1033:1047	The biosensor exhibited a limit of detection of 1.2 ng/L for microcystin-LR in local tap water.
32657575	5	38	theme	impedance	905:913	arg1	technique					928:936	a non-faradaic electrochemical impedance spectroscopy technique	874:936	a non-faradaic electrochemical impedance spectroscopy technique	874:936	A label-free and low-cost VAG biosensor based on a non-faradaic electrochemical impedance spectroscopy technique was fabricated.
32657575	7	39	theme	VAG	1073:1075	arg1	suitable					1090:1097	suitable	1090:1097	suitable	1090:1097	Such an ultrasensitive VAG biosensor is suitable for low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique.
32657575	7	39	theme	VAG	1073:1075	arg1	biosensor					1077:1085	Such an ultrasensitive VAG biosensor	1050:1085	Such an ultrasensitive VAG biosensor	1050:1085	Such an ultrasensitive VAG biosensor is suitable for low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique.
32657575	3	40	theme	toxins	607:612	arg1	detection					588:596	ultrasensitive detection	573:596	ultrasensitive detection of algal toxins	573:612	Herein, we report the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water.
32657575	1	41	theme	electronic	128:137	arg1	properties					153:162	excellent physical, electronic, and chemical properties	108:162	excellent physical, electronic, and chemical properties that are highly desirable for biosensing applications	108:216	Graphene exhibits excellent physical, electronic, and chemical properties that are highly desirable for biosensing applications.
32657575	7	42	theme	rapid	1188:1192	arg1	technique					1213:1221	rapid photonic annealing technique	1188:1221	rapid photonic annealing technique	1188:1221	Such an ultrasensitive VAG biosensor is suitable for low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique.
32657575	2	43	theme	most	228:231	arg1	biosensors					242:251	most graphene biosensors	228:251	most graphene biosensors	228:251	However, most graphene biosensors are based on graphene lying flat on a substrate and therefore do not utilize its maximum specific surface area for ultrasensitive detection.
32657575	2	44	theme	graphene	233:240	arg1	biosensors					242:251	most graphene biosensors	228:251	most graphene biosensors	228:251	However, most graphene biosensors are based on graphene lying flat on a substrate and therefore do not utilize its maximum specific surface area for ultrasensitive detection.
32657575	2	45	theme	specific	342:349	arg1	area					359:362	its maximum specific surface area	330:362	its maximum specific surface area for ultrasensitive detection	330:391	However, most graphene biosensors are based on graphene lying flat on a substrate and therefore do not utilize its maximum specific surface area for ultrasensitive detection.
32657575	4	46	theme	partial	725:731	arg1	removal					733:739	partial removal	725:739	partial removal of the polymeric binder	725:763	These VAG structures, which maximized the specific surface area of graphene, were formed by partial removal of the polymeric binder upon applying intense pulsed light on the printed graphene.
32657575	4	47	theme	graphene	700:707	arg1	area					692:695	the specific surface area	671:695	the specific surface area of graphene	671:707	These VAG structures, which maximized the specific surface area of graphene, were formed by partial removal of the polymeric binder upon applying intense pulsed light on the printed graphene.
32657575	2	48	theme	maximum	334:340	arg1	area					359:362	its maximum specific surface area	330:362	its maximum specific surface area for ultrasensitive detection	330:391	However, most graphene biosensors are based on graphene lying flat on a substrate and therefore do not utilize its maximum specific surface area for ultrasensitive detection.
32657575	3	49	theme	ultrasensitive	573:586	arg1	detection					588:596	ultrasensitive detection	573:596	ultrasensitive detection of algal toxins	573:612	Herein, we report the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water.
32657575	7	50	theme	ultrasensitive	1058:1071	arg1	suitable					1090:1097	suitable	1090:1097	suitable	1090:1097	Such an ultrasensitive VAG biosensor is suitable for low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique.
32657575	7	50	theme	ultrasensitive	1058:1071	arg1	biosensor					1077:1085	Such an ultrasensitive VAG biosensor	1050:1085	Such an ultrasensitive VAG biosensor	1050:1085	Such an ultrasensitive VAG biosensor is suitable for low-cost mass production using an integrated roll-to-roll flexographic printing with rapid photonic annealing technique.
32657575	3	51	theme	composite	503:511	arg1	cellulose					493:501	a flexographically printed graphene-ethyl cellulose	451:501	a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water	451:630	Herein, we report the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water.
32657575	5	52	theme	spectroscopy	915:926	arg1	technique					928:936	a non-faradaic electrochemical impedance spectroscopy technique	874:936	a non-faradaic electrochemical impedance spectroscopy technique	874:936	A label-free and low-cost VAG biosensor based on a non-faradaic electrochemical impedance spectroscopy technique was fabricated.
32657575	5	53	theme	low-cost	842:849	arg1	biosensor					855:863	A label-free and low-cost VAG biosensor	825:863	A label-free and low-cost VAG biosensor based on a non-faradaic electrochemical impedance spectroscopy technique	825:936	A label-free and low-cost VAG biosensor based on a non-faradaic electrochemical impedance spectroscopy technique was fabricated.
32657575	3	54	theme	graphene	543:550	arg1	biosensors					558:567	vertically aligned graphene (VAG) biosensors	524:567	vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins	524:612	Herein, we report the novel use of photonic annealing on a flexographically printed graphene-ethyl cellulose composite to produce vertically aligned graphene (VAG) biosensors for ultrasensitive detection of algal toxins in drinking water.
32657575	0	55	theme	Ultrasensitive	63:76	arg1	Biosensors					78:87	Ultrasensitive Biosensors	63:87	Ultrasensitive Biosensors	63:87	Vertically Aligned Graphene Prepared by Photonic Annealing for Ultrasensitive Biosensors.
32657575	4	56	theme	printed	807:813	arg1	graphene					815:822	the printed graphene	803:822	the printed graphene	803:822	These VAG structures, which maximized the specific surface area of graphene, were formed by partial removal of the polymeric binder upon applying intense pulsed light on the printed graphene.
32657575	2	57	theme	ultrasensitive	368:381	arg1	detection					383:391	ultrasensitive detection	368:391	ultrasensitive detection	368:391	However, most graphene biosensors are based on graphene lying flat on a substrate and therefore do not utilize its maximum specific surface area for ultrasensitive detection.
32657575	4	58	theme	VAG	639:641	arg1	structures					643:652	These VAG structures	633:652	These VAG structures	633:652	These VAG structures, which maximized the specific surface area of graphene, were formed by partial removal of the polymeric binder upon applying intense pulsed light on the printed graphene.
32679321	0	0	theme	healing	104:110	arg1	application					112:122	potential wound healing application	88:122	potential wound healing application	88:122	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.
32679321	0	1	with	films	50:54	arg1	properties					73:82	antioxidant properties	61:82	antioxidant properties	61:82	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.
32679321	1	2	theme	biomimetic	276:285	arg1	polypeptide					287:297	an elastin-derived biomimetic polypeptide	257:297	an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP)	257:336	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	0	3	theme	wound	98:102	arg1	application					112:122	potential wound healing application	88:122	potential wound healing application	88:122	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.
32679321	7	4	theme	Human	1166:1170	arg1	hDF					1192:1194	hDF	1192:1194	hDF	1192:1194	Human Dermal Fibroblasts (hDF) were used to test the in vitro cytocompatibility.
32679321	7	4	theme	Human	1166:1170	arg1	Fibroblasts					1179:1189	Human Dermal Fibroblasts	1166:1189	Human Dermal Fibroblasts (hDF)	1166:1195	Human Dermal Fibroblasts (hDF) were used to test the in vitro cytocompatibility.
32679321	5	5	from	degradation	1018:1028	arg1	kinetics					998:1005	swelling kinetics	989:1005	swelling kinetics	989:1005	Spectroscopic and thermal analyses confirmed an interaction between ALG and HELP which also causes a modification in swelling kinetics and faster degradation.
32679321	1	6	theme	polypeptide	287:297	arg1	combination					242:252	the combination	238:252	the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG)	238:356	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	2	7	theme	calcium	563:569	arg1	chloride					571:578	calcium chloride	563:578	calcium chloride	563:578	ALG/HELP composite films loaded with the hydrophobic natural antioxidant curcumin were prepared by solvent casting method followed by the cross-linking with calcium chloride.
32679321	1	8	dep	Polypeptide	319:329	arg1	HELP					332:335	HELP	332:335	HELP	332:335	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	8	9	dep	content	1307:1313	arg1	HELP					1302:1305	HELP	1302:1305	HELP	1302:1305	The antioxidant activity correlated to the increase of HELP content suggested the applicability of these composites to develop smart biomaterials.
32679321	5	10	theme	swelling	989:996	arg1	kinetics					998:1005	swelling kinetics	989:1005	swelling kinetics	989:1005	Spectroscopic and thermal analyses confirmed an interaction between ALG and HELP which also causes a modification in swelling kinetics and faster degradation.
32679321	8	11	theme	smart	1374:1378	arg1	biomaterials					1380:1391	smart biomaterials	1374:1391	smart biomaterials	1374:1391	The antioxidant activity correlated to the increase of HELP content suggested the applicability of these composites to develop smart biomaterials.
32679321	1	12	theme	Human	300:304	arg1	Polypeptide					319:329	Human Elastin-Like Polypeptide	300:329	Human Elastin-Like Polypeptide	300:329	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	4	13	dep	content	793:799	arg1	HELP					788:791	HELP	788:791	HELP	788:791	The micro-morphological study of films showed a homogeneous structure, but the film tensile strength decrease with HELP content and elongation at break was adversely affected by biopolymer addition.
32679321	6	14	theme	release	1128:1134	arg1	rate					1136:1139	a faster release rate	1119:1139	a faster release rate in the presence of HELP	1119:1163	Moreover, the study of curcumin release showed a controlled delivery up to 10 days with a faster release rate in the presence of HELP.
32679321	2	15	theme	ALG/HELP	406:413	arg1	films					425:429	ALG/HELP composite films	406:429	ALG/HELP composite films loaded with the hydrophobic natural antioxidant curcumin	406:486	ALG/HELP composite films loaded with the hydrophobic natural antioxidant curcumin were prepared by solvent casting method followed by the cross-linking with calcium chloride.
32679321	2	16	theme	composite	415:423	arg1	films					425:429	ALG/HELP composite films	406:429	ALG/HELP composite films loaded with the hydrophobic natural antioxidant curcumin	406:486	ALG/HELP composite films loaded with the hydrophobic natural antioxidant curcumin were prepared by solvent casting method followed by the cross-linking with calcium chloride.
32679321	9	17	theme	biomedical	1521:1530	arg1	applications					1532:1543	various biomedical applications	1513:1543	various biomedical applications	1513:1543	Overall, these features indicated how this composite material has considerable potential as customizable platforms for various biomedical applications.
32679321	2	18	theme	casting	513:519	arg1	method					521:526	solvent casting method	505:526	solvent casting method followed by the cross-linking with calcium chloride	505:578	ALG/HELP composite films loaded with the hydrophobic natural antioxidant curcumin were prepared by solvent casting method followed by the cross-linking with calcium chloride.
32679321	1	19	link	cross-linked	210:221	arg1	films					223:227	cross-linked films	210:227	cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG)	210:356	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	2	20	with	cross-linking	544:556	arg1	chloride					571:578	calcium chloride	563:578	calcium chloride	563:578	ALG/HELP composite films loaded with the hydrophobic natural antioxidant curcumin were prepared by solvent casting method followed by the cross-linking with calcium chloride.
32679321	2	21	theme	antioxidant	467:477	arg1	curcumin					479:486	the hydrophobic natural antioxidant curcumin	443:486	the hydrophobic natural antioxidant curcumin	443:486	ALG/HELP composite films loaded with the hydrophobic natural antioxidant curcumin were prepared by solvent casting method followed by the cross-linking with calcium chloride.
32679321	1	22	theme	series	200:205	arg1	characterization					178:193	characterization	178:193	characterization	178:193	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	1	22	theme	series	200:205	arg1	preparation					162:172	preparation	162:172	preparation	162:172	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	0	23	theme	elastin-like	15:26	arg1	polypeptide					28:38	Alginate/human elastin-like polypeptide	0:38	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.	0:123	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.
32679321	1	24	theme	enhanced	385:392	arg1	properties					394:403	enhanced properties	385:403	enhanced properties	385:403	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	1	25	link	elastin-derived	260:274	arg1	polypeptide					287:297	an elastin-derived biomimetic polypeptide	257:297	an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP)	257:336	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	4	26	dep	strength	765:772	arg1	decrease					774:781	decrease	774:781	decrease with HELP content and elongation at break	774:823	The micro-morphological study of films showed a homogeneous structure, but the film tensile strength decrease with HELP content and elongation at break was adversely affected by biopolymer addition.
32679321	0	27	theme	Alginate/human	0:13	arg1	polypeptide					28:38	Alginate/human elastin-like polypeptide	0:38	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.	0:123	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.
32679321	1	28	theme	Elastin-Like	306:317	arg1	Polypeptide					319:329	Human Elastin-Like Polypeptide	300:329	Human Elastin-Like Polypeptide	300:329	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	6	29	theme	curcumin	1054:1061	arg1	release					1063:1069	curcumin release	1054:1069	curcumin release	1054:1069	Moreover, the study of curcumin release showed a controlled delivery up to 10 days with a faster release rate in the presence of HELP.
32679321	1	30	theme	cross-linked	210:221	arg1	films					223:227	cross-linked films	210:227	cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG)	210:356	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	0	31	theme	composite	40:48	arg1	films					50:54	Alginate/human elastin-like polypeptide composite films	0:54	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.	0:123	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.
32679321	6	32	theme	faster	1121:1126	arg1	rate					1136:1139	a faster release rate	1119:1139	a faster release rate in the presence of HELP	1119:1163	Moreover, the study of curcumin release showed a controlled delivery up to 10 days with a faster release rate in the presence of HELP.
32679321	9	33	contain	has	1456:1458	arg2	potential					1473:1481	considerable potential	1460:1481	considerable potential	1460:1481	Overall, these features indicated how this composite material has considerable potential as customizable platforms for various biomedical applications.
32679321	9	33	contain	has	1456:1458	arg1	material					1447:1454	this composite material	1432:1454	this composite material	1432:1454	Overall, these features indicated how this composite material has considerable potential as customizable platforms for various biomedical applications.
32679321	9	33	contain	has	1456:1458	arg2	platforms					1499:1507	customizable platforms	1486:1507	customizable platforms for various biomedical applications	1486:1543	Overall, these features indicated how this composite material has considerable potential as customizable platforms for various biomedical applications.
32679321	1	34	dep	preparation	162:172	arg1	the					158:160	the	158:160	the	158:160	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	1	35	theme	films	223:227	arg1	series					200:205	a series	198:205	a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG)	198:356	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	0	36	theme	polypeptide	28:38	arg1	films					50:54	Alginate/human elastin-like polypeptide composite films	0:54	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.	0:123	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.
32679321	6	37	theme	release	1063:1069	arg1	study					1045:1049	the study	1041:1049	the study of curcumin release	1041:1069	Moreover, the study of curcumin release showed a controlled delivery up to 10 days with a faster release rate in the presence of HELP.
32679321	5	38	theme	faster	1011:1016	arg1	degradation					1018:1028	faster degradation	1011:1028	faster degradation	1011:1028	Spectroscopic and thermal analyses confirmed an interaction between ALG and HELP which also causes a modification in swelling kinetics and faster degradation.
32679321	5	39	theme	thermal	890:896	arg1	analyses					898:905	Spectroscopic and thermal analyses	872:905	Spectroscopic and thermal analyses	872:905	Spectroscopic and thermal analyses confirmed an interaction between ALG and HELP which also causes a modification in swelling kinetics and faster degradation.
32679321	2	40	theme	solvent	505:511	arg1	method					521:526	solvent casting method	505:526	solvent casting method followed by the cross-linking with calcium chloride	505:578	ALG/HELP composite films loaded with the hydrophobic natural antioxidant curcumin were prepared by solvent casting method followed by the cross-linking with calcium chloride.
32679321	9	41	theme	various	1513:1519	arg1	applications					1532:1543	various biomedical applications	1513:1543	various biomedical applications	1513:1543	Overall, these features indicated how this composite material has considerable potential as customizable platforms for various biomedical applications.
32679321	8	42	theme	content	1307:1313	arg1	increase					1290:1297	the increase	1286:1297	the increase of HELP content	1286:1313	The antioxidant activity correlated to the increase of HELP content suggested the applicability of these composites to develop smart biomaterials.
32679321	4	43	theme	films	706:710	arg1	study					697:701	The micro-morphological study	673:701	The micro-morphological study of films	673:710	The micro-morphological study of films showed a homogeneous structure, but the film tensile strength decrease with HELP content and elongation at break was adversely affected by biopolymer addition.
32679321	7	44	used	used	1202:1205	arg2	hDF					1192:1194	hDF	1192:1194	hDF	1192:1194	Human Dermal Fibroblasts (hDF) were used to test the in vitro cytocompatibility.
32679321	7	44	used	used	1202:1205	arg2	Fibroblasts					1179:1189	Human Dermal Fibroblasts	1166:1189	Human Dermal Fibroblasts (hDF)	1166:1195	Human Dermal Fibroblasts (hDF) were used to test the in vitro cytocompatibility.
32679321	2	45	theme	natural	459:465	arg1	curcumin					479:486	the hydrophobic natural antioxidant curcumin	443:486	the hydrophobic natural antioxidant curcumin	443:486	ALG/HELP composite films loaded with the hydrophobic natural antioxidant curcumin were prepared by solvent casting method followed by the cross-linking with calcium chloride.
32679321	4	46	theme	micro-morphological	677:695	arg1	study					697:701	The micro-morphological study	673:701	The micro-morphological study of films	673:710	The micro-morphological study of films showed a homogeneous structure, but the film tensile strength decrease with HELP content and elongation at break was adversely affected by biopolymer addition.
32679321	7	47	theme	Dermal	1172:1177	arg1	hDF					1192:1194	hDF	1192:1194	hDF	1192:1194	Human Dermal Fibroblasts (hDF) were used to test the in vitro cytocompatibility.
32679321	7	47	theme	Dermal	1172:1177	arg1	Fibroblasts					1179:1189	Human Dermal Fibroblasts	1166:1189	Human Dermal Fibroblasts (hDF)	1166:1195	Human Dermal Fibroblasts (hDF) were used to test the in vitro cytocompatibility.
32679321	7	48	theme	in	1219:1220	arg1	cytocompatibility					1228:1244	the in vitro cytocompatibility	1215:1244	the in vitro cytocompatibility	1215:1244	Human Dermal Fibroblasts (hDF) were used to test the in vitro cytocompatibility.
32679321	6	49	theme	delivery	1091:1098	arg1	up					1100:1101	a controlled delivery up	1078:1101	a controlled delivery up to 10 days	1078:1112	Moreover, the study of curcumin release showed a controlled delivery up to 10 days with a faster release rate in the presence of HELP.
32679321	9	50	theme	customizable	1486:1497	arg1	potential					1473:1481	considerable potential	1460:1481	considerable potential	1460:1481	Overall, these features indicated how this composite material has considerable potential as customizable platforms for various biomedical applications.
32679321	9	50	theme	customizable	1486:1497	arg1	platforms					1499:1507	customizable platforms	1486:1507	customizable platforms for various biomedical applications	1486:1543	Overall, these features indicated how this composite material has considerable potential as customizable platforms for various biomedical applications.
32679321	4	51	theme	film	752:755	arg1	strength					765:772	the film tensile strength	748:772	the film tensile strength decrease with HELP content and elongation at break	748:823	The micro-morphological study of films showed a homogeneous structure, but the film tensile strength decrease with HELP content and elongation at break was adversely affected by biopolymer addition.
32679321	0	52	theme	antioxidant	61:71	arg1	properties					73:82	antioxidant properties	61:82	antioxidant properties	61:82	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.
32679321	7	53	dep	in	1219:1220	arg1	vitro					1222:1226	vitro	1222:1226	vitro	1222:1226	Human Dermal Fibroblasts (hDF) were used to test the in vitro cytocompatibility.
32679321	5	54	from	modification	973:984	arg1	kinetics					998:1005	swelling kinetics	989:1005	swelling kinetics	989:1005	Spectroscopic and thermal analyses confirmed an interaction between ALG and HELP which also causes a modification in swelling kinetics and faster degradation.
32679321	4	55	theme	biopolymer	851:860	arg1	addition					862:869	biopolymer addition	851:869	biopolymer addition	851:869	The micro-morphological study of films showed a homogeneous structure, but the film tensile strength decrease with HELP content and elongation at break was adversely affected by biopolymer addition.
32679321	6	56	theme	HELP	1160:1163	arg1	presence					1148:1155	the presence	1144:1155	the presence of HELP	1144:1163	Moreover, the study of curcumin release showed a controlled delivery up to 10 days with a faster release rate in the presence of HELP.
32679321	6	57	theme	controlled	1080:1089	arg1	up					1100:1101	a controlled delivery up	1078:1101	a controlled delivery up to 10 days	1078:1112	Moreover, the study of curcumin release showed a controlled delivery up to 10 days with a faster release rate in the presence of HELP.
32679321	9	58	theme	considerable	1460:1471	arg1	potential					1473:1481	considerable potential	1460:1481	considerable potential	1460:1481	Overall, these features indicated how this composite material has considerable potential as customizable platforms for various biomedical applications.
32679321	9	58	theme	considerable	1460:1471	arg1	platforms					1499:1507	customizable platforms	1486:1507	customizable platforms for various biomedical applications	1486:1543	Overall, these features indicated how this composite material has considerable potential as customizable platforms for various biomedical applications.
32679321	5	59	theme	Spectroscopic	872:884	arg1	analyses					898:905	Spectroscopic and thermal analyses	872:905	Spectroscopic and thermal analyses	872:905	Spectroscopic and thermal analyses confirmed an interaction between ALG and HELP which also causes a modification in swelling kinetics and faster degradation.
32679321	4	60	theme	tensile	757:763	arg1	strength					765:772	the film tensile strength	748:772	the film tensile strength decrease with HELP content and elongation at break	748:823	The micro-morphological study of films showed a homogeneous structure, but the film tensile strength decrease with HELP content and elongation at break was adversely affected by biopolymer addition.
32679321	0	61	theme	potential	88:96	arg1	application					112:122	potential wound healing application	88:122	potential wound healing application	88:122	Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application.
32679321	1	62	dep	polypeptide	287:297	arg1	Polypeptide					319:329	Human Elastin-Like Polypeptide	300:329	Human Elastin-Like Polypeptide	300:329	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	3	63	theme	final	641:645	arg1	properties					647:656	the final properties	637:656	the two components as well as the final properties	607:656	The compatibility between the two components as well as the final properties was evaluated.
32679321	6	64	from	rate	1136:1139	arg1	presence					1148:1155	the presence	1144:1155	the presence of HELP	1144:1163	Moreover, the study of curcumin release showed a controlled delivery up to 10 days with a faster release rate in the presence of HELP.
32679321	8	65	theme	composites	1352:1361	arg1	applicability					1329:1341	the applicability	1325:1341	the applicability of these composites to develop smart biomaterials	1325:1391	The antioxidant activity correlated to the increase of HELP content suggested the applicability of these composites to develop smart biomaterials.
32679321	1	66	with	composite	370:378	arg1	properties					394:403	enhanced properties	385:403	enhanced properties	385:403	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	9	67	theme	composite	1437:1445	arg1	material					1447:1454	this composite material	1432:1454	this composite material	1432:1454	Overall, these features indicated how this composite material has considerable potential as customizable platforms for various biomedical applications.
32679321	8	68	theme	antioxidant	1251:1261	arg1	activity					1263:1270	The antioxidant activity	1247:1270	The antioxidant activity correlated to the increase of HELP content	1247:1313	The antioxidant activity correlated to the increase of HELP content suggested the applicability of these composites to develop smart biomaterials.
32679321	2	69	theme	hydrophobic	447:457	arg1	curcumin					479:486	the hydrophobic natural antioxidant curcumin	443:486	the hydrophobic natural antioxidant curcumin	443:486	ALG/HELP composite films loaded with the hydrophobic natural antioxidant curcumin were prepared by solvent casting method followed by the cross-linking with calcium chloride.
32679321	1	70	with	combination	242:252	arg1	ALG					353:355	ALG	353:355	ALG	353:355	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	1	70	with	combination	242:252	arg1	alginate					343:350	alginate	343:350	alginate (ALG)	343:356	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
32679321	4	71	theme	homogeneous	721:731	arg1	structure					733:741	a homogeneous structure	719:741	a homogeneous structure	719:741	The micro-morphological study of films showed a homogeneous structure, but the film tensile strength decrease with HELP content and elongation at break was adversely affected by biopolymer addition.
32679321	1	72	theme	elastin-derived	260:274	arg1	polypeptide					287:297	an elastin-derived biomimetic polypeptide	257:297	an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP)	257:336	In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human Elastin-Like Polypeptide, HELP) with alginate (ALG) to obtain a composite with enhanced properties.
33648239	10	0	theme	wheat	1228:1232	arg1	lipids					1240:1245	free wheat flour lipids	1223:1245	free wheat flour lipids	1223:1245	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	4	1	theme	Diluted	492:498	arg1	batter					500:505	Diluted batter	492:505	Diluted batter	492:505	Diluted batter was whipped and the resulting foam was used as model system for the air-liquid interface in sponge cake batter.
33648239	10	2	theme	sponge	1343:1348	arg1	batter					1355:1360	sponge cake batter	1343:1360	sponge cake batter	1343:1360	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	1	3	theme	interface	139:147	arg1	stability					149:157	air-liquid interface stability	128:157	air-liquid interface stability	128:157	The impact of free wheat flour lipids on air-liquid interface stability during sponge cake making was investigated.
33648239	0	4	theme	cake	74:77	arg1	batter					79:84	sponge cake batter	67:84	sponge cake batter	67:84	Free wheat flour lipids decrease air-liquid interface stability in sponge cake batter.
33648239	5	5	theme	prior	643:647	arg1	lipids					636:641	Relocating flour lipids	619:641	Relocating flour lipids prior to batter making	619:664	Relocating flour lipids prior to batter making enabled them to adsorb at the air-liquid interface in the foam.
33648239	9	6	theme	air-liquid	1163:1172	arg1	stability					1184:1192	air-liquid interface stability	1163:1192	air-liquid interface stability	1163:1192	The resultant molecular population improved air-liquid interface stability in sponge cake batter.
33648239	9	7	theme	sponge	1197:1202	arg1	batter					1209:1214	sponge cake batter	1197:1214	sponge cake batter	1197:1214	The resultant molecular population improved air-liquid interface stability in sponge cake batter.
33648239	6	8	theme	population	867:876	arg1	composition					831:841	the composition	827:841	the composition of the adsorbed protein population	827:876	This limited the degree of protein adsorption at the air-liquid interface, but it did not impact the composition of the adsorbed protein population.
33648239	6	9	theme	air-liquid	783:792	arg1	interface					794:802	the air-liquid interface	779:802	the air-liquid interface	779:802	This limited the degree of protein adsorption at the air-liquid interface, but it did not impact the composition of the adsorbed protein population.
33648239	2	10	dep	either	335:340	arg1	relocated					342:350	relocated	342:350	relocated	342:350	Therefore, the molecular population at the air-liquid interface in batters prepared with flour of which part of the lipids had been either relocated or removed prior to batter preparation was determined.
33648239	10	11	theme	flour	1234:1238	arg1	lipids					1240:1245	free wheat flour lipids	1223:1245	free wheat flour lipids	1223:1245	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	4	12	theme	air-liquid	575:584	arg1	interface					586:594	the air-liquid interface	571:594	the air-liquid interface in sponge cake batter	571:616	Diluted batter was whipped and the resulting foam was used as model system for the air-liquid interface in sponge cake batter.
33648239	9	13	theme	resultant	1123:1131	arg1	population					1143:1152	The resultant molecular population	1119:1152	The resultant molecular population	1119:1152	The resultant molecular population improved air-liquid interface stability in sponge cake batter.
33648239	6	14	theme	protein	859:865	arg1	population					867:876	the adsorbed protein population	846:876	the adsorbed protein population	846:876	This limited the degree of protein adsorption at the air-liquid interface, but it did not impact the composition of the adsorbed protein population.
33648239	4	15	used	used	546:549	arg2	system					560:565	model system	554:565	model system for the air-liquid interface in sponge cake batter	554:616	Diluted batter was whipped and the resulting foam was used as model system for the air-liquid interface in sponge cake batter.
33648239	4	15	used	used	546:549	arg2	foam					537:540	the resulting foam	523:540	the resulting foam	523:540	Diluted batter was whipped and the resulting foam was used as model system for the air-liquid interface in sponge cake batter.
33648239	7	16	theme	making	917:922	arg1	batter					910:915	batter making	910:922	batter making	910:922	Removing flour lipids prior to batter making resulted in foam containing relatively higher levels of lipids mainly originating from egg yolk.
33648239	10	17	theme	solvent	1282:1288	arg1	stability					1330:1338	solvent treatment decrease air-liquid interface stability	1282:1338	solvent treatment decrease air-liquid interface stability in sponge cake batter	1282:1360	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	3	18	theme	separation	471:480	arg1	protocol					482:489	a foam separation protocol	464:489	a foam separation protocol	464:489	Surface-active molecules were isolated from batter using a foam separation protocol.
33648239	6	19	theme	adsorbed	850:857	arg1	population					867:876	the adsorbed protein population	846:876	the adsorbed protein population	846:876	This limited the degree of protein adsorption at the air-liquid interface, but it did not impact the composition of the adsorbed protein population.
33648239	6	20	from	interface	794:802	arg1	degree					747:752	the degree	743:752	the degree of protein adsorption at the air-liquid interface	743:802	This limited the degree of protein adsorption at the air-liquid interface, but it did not impact the composition of the adsorbed protein population.
33648239	2	21	theme	batter	372:377	arg1	preparation					379:389	batter preparation	372:389	batter preparation	372:389	Therefore, the molecular population at the air-liquid interface in batters prepared with flour of which part of the lipids had been either relocated or removed prior to batter preparation was determined.
33648239	10	22	theme	protein-dominated	1440:1456	arg1	interface					1458:1466	the protein-dominated interface	1436:1466	the protein-dominated interface	1436:1466	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	8	23	theme	Prior	1021:1025	arg1	removal					1027:1033	Prior removal	1021:1033	Prior removal of flour lipids	1021:1049	Prior removal of flour lipids impacted neither foam protein content nor foam protein composition.
33648239	3	24	attach	isolated	437:444	arg1	batter					451:456	batter	451:456	batter	451:456	Surface-active molecules were isolated from batter using a foam separation protocol.
33648239	3	24	attach	isolated	437:444	arg2	molecules					422:430	Surface-active molecules	407:430	Surface-active molecules	407:430	Surface-active molecules were isolated from batter using a foam separation protocol.
33648239	2	25	from	population	228:237	arg1	batters					270:276	batters	270:276	batters prepared with flour of which part of the lipids had been either relocated or removed prior to batter preparation	270:389	Therefore, the molecular population at the air-liquid interface in batters prepared with flour of which part of the lipids had been either relocated or removed prior to batter preparation was determined.
33648239	1	26	theme	sponge	166:171	arg1	cake					173:176	sponge cake making	166:183	sponge cake making	166:183	The impact of free wheat flour lipids on air-liquid interface stability during sponge cake making was investigated.
33648239	0	27	theme	wheat	5:9	arg1	lipids					17:22	Free wheat flour lipids	0:22	Free wheat flour lipids	0:22	Free wheat flour lipids decrease air-liquid interface stability in sponge cake batter.
33648239	4	28	from	interface	586:594	arg1	batter					611:616	sponge cake batter	599:616	sponge cake batter	599:616	Diluted batter was whipped and the resulting foam was used as model system for the air-liquid interface in sponge cake batter.
33648239	5	29	theme	Relocating	619:628	arg1	lipids					636:641	Relocating flour lipids	619:641	Relocating flour lipids prior to batter making	619:664	Relocating flour lipids prior to batter making enabled them to adsorb at the air-liquid interface in the foam.
33648239	6	30	theme	protein	757:763	arg1	adsorption					765:774	protein adsorption	757:774	protein adsorption	757:774	This limited the degree of protein adsorption at the air-liquid interface, but it did not impact the composition of the adsorbed protein population.
33648239	10	31	theme	flour	1257:1261	arg1	lipids					1263:1268	wheat flour lipids	1251:1268	wheat flour lipids	1251:1268	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	3	32	theme	Surface-active	407:420	arg1	molecules					422:430	Surface-active molecules	407:430	Surface-active molecules	407:430	Surface-active molecules were isolated from batter using a foam separation protocol.
33648239	0	33	theme	Free	0:3	arg1	lipids					17:22	Free wheat flour lipids	0:22	Free wheat flour lipids	0:22	Free wheat flour lipids decrease air-liquid interface stability in sponge cake batter.
33648239	5	34	theme	flour	630:634	arg1	lipids					636:641	Relocating flour lipids	619:641	Relocating flour lipids prior to batter making	619:664	Relocating flour lipids prior to batter making enabled them to adsorb at the air-liquid interface in the foam.
33648239	9	35	theme	cake	1204:1207	arg1	batter					1209:1214	sponge cake batter	1197:1214	sponge cake batter	1197:1214	The resultant molecular population improved air-liquid interface stability in sponge cake batter.
33648239	1	36	theme	making	178:183	arg1	cake					173:176	sponge cake making	166:183	sponge cake making	166:183	The impact of free wheat flour lipids on air-liquid interface stability during sponge cake making was investigated.
33648239	10	37	theme	air-liquid	1309:1318	arg1	stability					1330:1338	solvent treatment decrease air-liquid interface stability	1282:1338	solvent treatment decrease air-liquid interface stability in sponge cake batter	1282:1360	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	7	38	theme	prior	901:905	arg1	lipids					894:899	Removing flour lipids	879:899	Removing flour lipids prior to batter making	879:922	Removing flour lipids prior to batter making resulted in foam containing relatively higher levels of lipids mainly originating from egg yolk.
33648239	9	39	theme	interface	1174:1182	arg1	stability					1184:1192	air-liquid interface stability	1163:1192	air-liquid interface stability	1163:1192	The resultant molecular population improved air-liquid interface stability in sponge cake batter.
33648239	10	40	theme	treatment	1290:1298	arg1	stability					1330:1338	solvent treatment decrease air-liquid interface stability	1282:1338	solvent treatment decrease air-liquid interface stability in sponge cake batter	1282:1360	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	0	41	theme	flour	11:15	arg1	lipids					17:22	Free wheat flour lipids	0:22	Free wheat flour lipids	0:22	Free wheat flour lipids decrease air-liquid interface stability in sponge cake batter.
33648239	4	42	theme	model	554:558	arg1	system					560:565	model system	554:565	model system for the air-liquid interface in sponge cake batter	554:616	Diluted batter was whipped and the resulting foam was used as model system for the air-liquid interface in sponge cake batter.
33648239	4	42	theme	model	554:558	arg1	foam					537:540	the resulting foam	523:540	the resulting foam	523:540	Diluted batter was whipped and the resulting foam was used as model system for the air-liquid interface in sponge cake batter.
33648239	8	43	theme	lipids	1044:1049	arg1	removal					1027:1033	Prior removal	1021:1033	Prior removal of flour lipids	1021:1049	Prior removal of flour lipids impacted neither foam protein content nor foam protein composition.
33648239	10	44	theme	protein	1388:1394	arg1	adsorption					1396:1405	protein adsorption	1388:1405	protein adsorption	1388:1405	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	2	45	from	interface	257:265	arg1	population					228:237	the molecular population	214:237	the molecular population at the air-liquid interface in batters prepared with flour of which part of the lipids had been either relocated or removed prior to batter preparation	214:389	Therefore, the molecular population at the air-liquid interface in batters prepared with flour of which part of the lipids had been either relocated or removed prior to batter preparation was determined.
33648239	10	46	theme	decrease	1300:1307	arg1	stability					1330:1338	solvent treatment decrease air-liquid interface stability	1282:1338	solvent treatment decrease air-liquid interface stability in sponge cake batter	1282:1360	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	0	47	theme	air-liquid	33:42	arg1	stability					54:62	air-liquid interface stability	33:62	air-liquid interface stability	33:62	Free wheat flour lipids decrease air-liquid interface stability in sponge cake batter.
33648239	2	48	theme	lipids	319:324	arg1	part					307:310	part	307:310	part of the lipids	307:324	Therefore, the molecular population at the air-liquid interface in batters prepared with flour of which part of the lipids had been either relocated or removed prior to batter preparation was determined.
33648239	8	49	theme	foam	1068:1071	arg1	content					1081:1087	foam protein content	1068:1087	foam protein content	1068:1087	Prior removal of flour lipids impacted neither foam protein content nor foam protein composition.
33648239	10	50	from	stability	1330:1338	arg1	batter					1355:1360	sponge cake batter	1343:1360	sponge cake batter	1343:1360	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	7	51	theme	Removing	879:886	arg1	lipids					894:899	Removing flour lipids	879:899	Removing flour lipids prior to batter making	879:922	Removing flour lipids prior to batter making resulted in foam containing relatively higher levels of lipids mainly originating from egg yolk.
33648239	5	52	theme	air-liquid	696:705	arg1	interface					707:715	the air-liquid interface	692:715	the air-liquid interface in the foam	692:727	Relocating flour lipids prior to batter making enabled them to adsorb at the air-liquid interface in the foam.
33648239	5	53	from	interface	707:715	arg1	foam					724:727	the foam	720:727	the foam	720:727	Relocating flour lipids prior to batter making enabled them to adsorb at the air-liquid interface in the foam.
33648239	2	54	theme	molecular	218:226	arg1	population					228:237	the molecular population	214:237	the molecular population at the air-liquid interface in batters prepared with flour of which part of the lipids had been either relocated or removed prior to batter preparation	214:389	Therefore, the molecular population at the air-liquid interface in batters prepared with flour of which part of the lipids had been either relocated or removed prior to batter preparation was determined.
33648239	5	55	theme	making	659:664	arg1	batter					652:657	batter making	652:664	batter making	652:664	Relocating flour lipids prior to batter making enabled them to adsorb at the air-liquid interface in the foam.
33648239	8	56	theme	protein	1098:1104	arg1	composition					1106:1116	foam protein composition	1093:1116	foam protein composition	1093:1116	Prior removal of flour lipids impacted neither foam protein content nor foam protein composition.
33648239	1	57	theme	free	101:104	arg1	lipids					118:123	free wheat flour lipids	101:123	free wheat flour lipids	101:123	The impact of free wheat flour lipids on air-liquid interface stability during sponge cake making was investigated.
33648239	0	58	theme	interface	44:52	arg1	stability					54:62	air-liquid interface stability	33:62	air-liquid interface stability	33:62	Free wheat flour lipids decrease air-liquid interface stability in sponge cake batter.
33648239	8	59	theme	protein	1073:1079	arg1	content					1081:1087	foam protein content	1068:1087	foam protein content	1068:1087	Prior removal of flour lipids impacted neither foam protein content nor foam protein composition.
33648239	10	60	theme	interface	1320:1328	arg1	stability					1330:1338	solvent treatment decrease air-liquid interface stability	1282:1338	solvent treatment decrease air-liquid interface stability in sponge cake batter	1282:1360	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	1	61	theme	wheat	106:110	arg1	lipids					118:123	free wheat flour lipids	101:123	free wheat flour lipids	101:123	The impact of free wheat flour lipids on air-liquid interface stability during sponge cake making was investigated.
33648239	1	62	from	impact	91:96	arg1	stability					149:157	air-liquid interface stability	128:157	air-liquid interface stability	128:157	The impact of free wheat flour lipids on air-liquid interface stability during sponge cake making was investigated.
33648239	4	63	theme	resulting	527:535	arg1	system					560:565	model system	554:565	model system for the air-liquid interface in sponge cake batter	554:616	Diluted batter was whipped and the resulting foam was used as model system for the air-liquid interface in sponge cake batter.
33648239	4	63	theme	resulting	527:535	arg1	foam					537:540	the resulting foam	523:540	the resulting foam	523:540	Diluted batter was whipped and the resulting foam was used as model system for the air-liquid interface in sponge cake batter.
33648239	8	64	theme	foam	1093:1096	arg1	composition					1106:1116	foam protein composition	1093:1116	foam protein composition	1093:1116	Prior removal of flour lipids impacted neither foam protein content nor foam protein composition.
33648239	6	65	theme	adsorption	765:774	arg1	degree					747:752	the degree	743:752	the degree of protein adsorption at the air-liquid interface	743:802	This limited the degree of protein adsorption at the air-liquid interface, but it did not impact the composition of the adsorbed protein population.
33648239	7	66	theme	lipids	980:985	arg1	levels					970:975	relatively higher levels	952:975	relatively higher levels of lipids mainly originating from egg yolk	952:1018	Removing flour lipids prior to batter making resulted in foam containing relatively higher levels of lipids mainly originating from egg yolk.
33648239	1	67	theme	flour	112:116	arg1	lipids					118:123	free wheat flour lipids	101:123	free wheat flour lipids	101:123	The impact of free wheat flour lipids on air-liquid interface stability during sponge cake making was investigated.
33648239	7	68	theme	flour	888:892	arg1	lipids					894:899	Removing flour lipids	879:899	Removing flour lipids prior to batter making	879:922	Removing flour lipids prior to batter making resulted in foam containing relatively higher levels of lipids mainly originating from egg yolk.
33648239	7	69	theme	egg	1011:1013	arg1	yolk					1015:1018	egg yolk	1011:1018	egg yolk	1011:1018	Removing flour lipids prior to batter making resulted in foam containing relatively higher levels of lipids mainly originating from egg yolk.
33648239	2	70	theme	air-liquid	246:255	arg1	interface					257:265	the air-liquid interface	242:265	the air-liquid interface	242:265	Therefore, the molecular population at the air-liquid interface in batters prepared with flour of which part of the lipids had been either relocated or removed prior to batter preparation was determined.
33648239	7	71	theme	higher	963:968	arg1	levels					970:975	relatively higher levels	952:975	relatively higher levels of lipids mainly originating from egg yolk	952:1018	Removing flour lipids prior to batter making resulted in foam containing relatively higher levels of lipids mainly originating from egg yolk.
33648239	1	72	theme	lipids	118:123	arg1	impact					91:96	The impact	87:96	The impact of free wheat flour lipids on air-liquid interface stability during sponge cake making	87:183	The impact of free wheat flour lipids on air-liquid interface stability during sponge cake making was investigated.
33648239	3	73	theme	foam	466:469	arg1	protocol					482:489	a foam separation protocol	464:489	a foam separation protocol	464:489	Surface-active molecules were isolated from batter using a foam separation protocol.
33648239	0	74	theme	sponge	67:72	arg1	batter					79:84	sponge cake batter	67:84	sponge cake batter	67:84	Free wheat flour lipids decrease air-liquid interface stability in sponge cake batter.
33648239	10	75	dep	limit	1382:1386	arg1	interfere					1421:1429	interfere	1421:1429	interfere with the protein-dominated interface	1421:1466	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	9	76	theme	molecular	1133:1141	arg1	population					1143:1152	The resultant molecular population	1119:1152	The resultant molecular population	1119:1152	The resultant molecular population improved air-liquid interface stability in sponge cake batter.
33648239	10	77	theme	free	1223:1226	arg1	lipids					1240:1245	free wheat flour lipids	1223:1245	free wheat flour lipids	1223:1245	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	4	78	theme	cake	606:609	arg1	batter					611:616	sponge cake batter	599:616	sponge cake batter	599:616	Diluted batter was whipped and the resulting foam was used as model system for the air-liquid interface in sponge cake batter.
33648239	7	79	contain	containing	941:950	arg2	levels					970:975	relatively higher levels	952:975	relatively higher levels of lipids mainly originating from egg yolk	952:1018	Removing flour lipids prior to batter making resulted in foam containing relatively higher levels of lipids mainly originating from egg yolk.
33648239	7	79	contain	containing	941:950	arg1	foam					936:939	foam	936:939	foam containing relatively higher levels of lipids mainly originating from egg yolk	936:1018	Removing flour lipids prior to batter making resulted in foam containing relatively higher levels of lipids mainly originating from egg yolk.
33648239	8	80	theme	flour	1038:1042	arg1	lipids					1044:1049	flour lipids	1038:1049	flour lipids	1038:1049	Prior removal of flour lipids impacted neither foam protein content nor foam protein composition.
33648239	10	81	theme	cake	1350:1353	arg1	batter					1355:1360	sponge cake batter	1343:1360	sponge cake batter	1343:1360	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	1	82	theme	air-liquid	128:137	arg1	stability					149:157	air-liquid interface stability	128:157	air-liquid interface stability	128:157	The impact of free wheat flour lipids on air-liquid interface stability during sponge cake making was investigated.
33648239	10	83	theme	wheat	1251:1255	arg1	lipids					1263:1268	wheat flour lipids	1251:1268	wheat flour lipids	1251:1268	Thus, free wheat flour lipids and wheat flour lipids set free by solvent treatment decrease air-liquid interface stability in sponge cake batter mainly because they limit protein adsorption and, as such, interfere with the protein-dominated interface.
33648239	4	84	theme	sponge	599:604	arg1	batter					611:616	sponge cake batter	599:616	sponge cake batter	599:616	Diluted batter was whipped and the resulting foam was used as model system for the air-liquid interface in sponge cake batter.
32694823	4	0	theme	offspring	1030:1038	arg1	health					1050:1055	offspring metabolic health	1030:1055	offspring metabolic health	1030:1055	In global 3'-SL knockout mice (3'-SL-/-), maternal exercise training failed to improve offspring metabolic health or cardiac function in mice.
32694823	2	1	theme	animal	334:339	arg1	models					341:346	animal models	334:346	animal models	334:346	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	5	2	theme	3'-SL-	1201:1206	arg1	dams					1210:1213	exercise-trained 3'-SL-/- dams	1184:1213	exercise-trained 3'-SL-/- dams	1184:1213	There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood.
32694823	2	3	from	studies	323:329	arg1	models					341:346	animal models	334:346	animal models	334:346	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	6	4	theme	body	1449:1452	arg1	composition					1454:1464	body composition	1449:1464	body composition	1449:1464	Importantly, supplementation of 3'-SL negated the detrimental effects of a high-fat diet on body composition and metabolism.
32694823	5	5	from	dams	1210:1213	arg1	milk					1174:1177	milk	1174:1177	milk from exercise-trained 3'-SL-/- dams	1174:1213	There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood.
32694823	8	6	theme	disease	1760:1766	arg1	development					1701:1711	the development	1697:1711	the development of obesity, type 2 diabetes and cardiovascular disease	1697:1766	3'-SL supplementation is a potential therapeutic approach to combat the development of obesity, type 2 diabetes and cardiovascular disease.
32694823	2	7	theme	maternal	590:597	arg1	exercise					599:606	maternal exercise	590:606	maternal exercise to improve offspring's health	590:636	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	4	8	dep	mice	968:971	arg1	/-					980:981	/-	980:981	/-	980:981	In global 3'-SL knockout mice (3'-SL-/-), maternal exercise training failed to improve offspring metabolic health or cardiac function in mice.
32694823	3	9	theme	maternal	843:850	arg1	exercise					852:859	maternal exercise	843:859	maternal exercise	843:859	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	5	10	theme	/-	1207:1208	arg1	dams					1210:1213	exercise-trained 3'-SL-/- dams	1184:1213	exercise-trained 3'-SL-/- dams	1184:1213	There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood.
32694823	5	11	theme	beneficial	1099:1108	arg1	effect					1110:1115	no beneficial effect	1096:1115	no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams	1096:1213	There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood.
32694823	4	12	from	health	1050:1055	arg1	mice					1080:1083	mice	1080:1083	mice	1080:1083	In global 3'-SL knockout mice (3'-SL-/-), maternal exercise training failed to improve offspring metabolic health or cardiac function in mice.
32694823	3	13	theme	metabolic	882:890	arg1	health					892:897	mouse offspring's metabolic health	864:897	mouse offspring's metabolic health	864:897	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	7	14	theme	maternal	1588:1595	arg1	exercise					1597:1604	maternal exercise	1588:1604	maternal exercise	1588:1604	The present study reveals a critical role for the oligosaccharide 3'-SL in milk to mediate the effects of maternal exercise on offspring's health.
32694823	2	15	theme	cardiovascular	495:508	arg1	function16					510:519	decreased cardiovascular function16	485:519	decreased cardiovascular function16	485:519	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	8	16	dep	potential	1656:1664	arg1	therapeutic					1666:1676	therapeutic	1666:1676	therapeutic	1666:1676	3'-SL supplementation is a potential therapeutic approach to combat the development of obesity, type 2 diabetes and cardiovascular disease.
32694823	6	17	theme	3'-SL	1389:1393	arg1	supplementation					1370:1384	supplementation	1370:1384	supplementation of 3'-SL	1370:1393	Importantly, supplementation of 3'-SL negated the detrimental effects of a high-fat diet on body composition and metabolism.
32694823	4	18	theme	global	946:951	arg1	mice					968:971	global 3'-SL knockout mice	946:971	global 3'-SL knockout mice (3'-SL-/-)	946:982	In global 3'-SL knockout mice (3'-SL-/-), maternal exercise training failed to improve offspring metabolic health or cardiac function in mice.
32694823	5	19	theme	wild-type	1264:1272	arg1	mice					1274:1277	wild-type mice	1264:1277	wild-type mice	1264:1277	There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood.
32694823	2	20	theme	adiposity11,15	535:548	arg1	development					436:446	the age-related development	420:446	the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15	420:548	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	0	21	theme	cardiac	104:110	arg1	function					112:119	cardiac function	104:119	cardiac function	104:119	Exercise-induced 3'-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring.
32694823	2	22	theme	maternal	364:371	arg1	exercise					373:380	maternal exercise	364:380	maternal exercise before and during pregnancy	364:408	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	0	23	theme	Exercise-induced	0:15	arg1	mediator					63:70	a critical mediator	52:70	a critical mediator to improve metabolic health and cardiac function in mouse offspring	52:138	Exercise-induced 3'-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring.
32694823	0	23	theme	Exercise-induced	0:15	arg1	3'-sialyllactose					17:32	Exercise-induced 3'-sialyllactose	0:32	Exercise-induced 3'-sialyllactose in breast milk	0:47	Exercise-induced 3'-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring.
32694823	1	24	theme	type	256:259	arg1	diabetes					263:270	type 2 diabetes	256:270	type 2 diabetes	256:270	Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9.
32694823	2	25	theme	age-related	424:434	arg1	development					436:446	the age-related development	420:446	the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15	420:548	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	5	26	theme	cardiac	1309:1315	arg1	function					1317:1324	cardiac function	1309:1324	cardiac function	1309:1324	There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood.
32694823	6	27	theme	diet	1441:1444	arg1	effects					1419:1425	the detrimental effects	1403:1425	the detrimental effects of a high-fat diet on body composition and metabolism	1403:1479	Importantly, supplementation of 3'-SL negated the detrimental effects of a high-fat diet on body composition and metabolism.
32694823	1	28	theme	diabetes	263:270	arg1	development					232:242	the development	228:242	the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9	228:313	Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9.
32694823	3	29	theme	present	671:677	arg1	study					679:683	the present study	667:683	the present study	667:683	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	1	30	theme	cardiovascular	276:289	arg1	disease					291:297	cardiovascular disease	276:297	cardiovascular disease	276:297	Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9.
32694823	7	31	from	effects	1577:1583	arg1	health					1621:1626	offspring's health	1609:1626	offspring's health	1609:1626	The present study reveals a critical role for the oligosaccharide 3'-SL in milk to mediate the effects of maternal exercise on offspring's health.
32694823	7	32	theme	oligosaccharide	1532:1546	arg1	3'-SL					1548:1552	the oligosaccharide 3'-SL	1528:1552	the oligosaccharide 3'-SL	1528:1552	The present study reveals a critical role for the oligosaccharide 3'-SL in milk to mediate the effects of maternal exercise on offspring's health.
32694823	4	33	theme	exercise	994:1001	arg1	training					1003:1010	maternal exercise training	985:1010	maternal exercise training	985:1010	In global 3'-SL knockout mice (3'-SL-/-), maternal exercise training failed to improve offspring metabolic health or cardiac function in mice.
32694823	5	34	theme	exercise	1129:1136	arg1	effect					1110:1115	no beneficial effect	1096:1115	no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams	1096:1213	There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood.
32694823	5	35	from	effect	1110:1115	arg1	offspring					1151:1159	wild-type offspring	1141:1159	wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams	1141:1213	There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood.
32694823	5	36	theme	wild-type	1141:1149	arg1	offspring					1151:1159	wild-type offspring	1141:1159	wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams	1141:1213	There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood.
32694823	2	37	theme	Recent	316:321	arg1	studies					323:329	Recent studies	316:329	Recent studies in animal models	316:346	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	8	38	theme	potential	1656:1664	arg1	approach					1678:1685	a potential therapeutic approach	1654:1685	a potential therapeutic approach to combat the development of obesity, type 2 diabetes and cardiovascular disease	1654:1766	3'-SL supplementation is a potential therapeutic approach to combat the development of obesity, type 2 diabetes and cardiovascular disease.
32694823	8	38	theme	potential	1656:1664	arg1	supplementation					1635:1649	3'-SL supplementation	1629:1649	3'-SL supplementation	1629:1649	3'-SL supplementation is a potential therapeutic approach to combat the development of obesity, type 2 diabetes and cardiovascular disease.
32694823	7	39	theme	critical	1510:1517	arg1	role					1519:1522	a critical role	1508:1522	a critical role for the oligosaccharide 3'-SL in milk	1508:1560	The present study reveals a critical role for the oligosaccharide 3'-SL in milk to mediate the effects of maternal exercise on offspring's health.
32694823	1	40	theme	maternal	146:153	arg1	under-					177:182	under-	177:182	under-	177:182	Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9.
32694823	1	40	theme	maternal	146:153	arg1	environments					155:166	Poor maternal environments	141:166	Poor maternal environments	141:166	Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9.
32694823	1	40	theme	maternal	146:153	arg1	overnutrition					187:199	overnutrition	187:199	overnutrition	187:199	Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9.
32694823	7	41	from	role	1519:1522	arg1	milk					1557:1560	milk	1557:1560	milk	1557:1560	The present study reveals a critical role for the oligosaccharide 3'-SL in milk to mediate the effects of maternal exercise on offspring's health.
32694823	4	42	theme	metabolic	1040:1048	arg1	health					1050:1055	offspring metabolic health	1030:1055	offspring metabolic health	1030:1055	In global 3'-SL knockout mice (3'-SL-/-), maternal exercise training failed to improve offspring metabolic health or cardiac function in mice.
32694823	5	43	theme	exercise-trained	1184:1199	arg1	dams					1210:1213	exercise-trained 3'-SL-/- dams	1184:1213	exercise-trained 3'-SL-/- dams	1184:1213	There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood.
32694823	2	44	dep	exercise	599:606	arg1	improve					611:617	improve	611:617	to improve offspring's health	608:636	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	7	45	theme	present	1486:1492	arg1	study					1494:1498	The present study	1482:1498	The present study	1482:1498	The present study reveals a critical role for the oligosaccharide 3'-SL in milk to mediate the effects of maternal exercise on offspring's health.
32694823	8	46	theme	3'-SL	1629:1633	arg1	approach					1678:1685	a potential therapeutic approach	1654:1685	a potential therapeutic approach to combat the development of obesity, type 2 diabetes and cardiovascular disease	1654:1766	3'-SL supplementation is a potential therapeutic approach to combat the development of obesity, type 2 diabetes and cardiovascular disease.
32694823	8	46	theme	3'-SL	1629:1633	arg1	supplementation					1635:1649	3'-SL supplementation	1629:1649	3'-SL supplementation	1629:1649	3'-SL supplementation is a potential therapeutic approach to combat the development of obesity, type 2 diabetes and cardiovascular disease.
32694823	3	47	theme	exercise-induced	701:716	arg1	increase					718:725	an exercise-induced increase	698:725	an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice	698:800	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	1	48	theme	obesity	247:253	arg1	development					232:242	the development	228:242	the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9	228:313	Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9.
32694823	8	49	theme	obesity	1716:1722	arg1	development					1701:1711	the development	1697:1711	the development of obesity, type 2 diabetes and cardiovascular disease	1697:1766	3'-SL supplementation is a potential therapeutic approach to combat the development of obesity, type 2 diabetes and cardiovascular disease.
32694823	4	50	theme	maternal	985:992	arg1	training					1003:1010	maternal exercise training	985:1010	maternal exercise training	985:1010	In global 3'-SL knockout mice (3'-SL-/-), maternal exercise training failed to improve offspring metabolic health or cardiac function in mice.
32694823	3	51	theme	oligosaccharide	734:748	arg1	3'-SL					768:772	3'-SL	768:772	3'-SL	768:772	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	3	51	theme	oligosaccharide	734:748	arg1	3'-sialyllactose					750:765	the oligosaccharide 3'-sialyllactose	730:765	the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice	730:800	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	8	52	theme	type	1725:1728	arg1	diabetes					1732:1739	type 2 diabetes	1725:1739	type 2 diabetes	1725:1739	3'-SL supplementation is a potential therapeutic approach to combat the development of obesity, type 2 diabetes and cardiovascular disease.
32694823	3	53	from	3'-sialyllactose	750:765	arg1	milk					778:781	milk	778:781	milk in humans and mice	778:800	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	0	54	theme	mouse	124:128	arg1	offspring					130:138	mouse offspring	124:138	mouse offspring	124:138	Exercise-induced 3'-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring.
32694823	8	55	theme	diabetes	1732:1739	arg1	development					1701:1711	the development	1697:1711	the development of obesity, type 2 diabetes and cardiovascular disease	1697:1766	3'-SL supplementation is a potential therapeutic approach to combat the development of obesity, type 2 diabetes and cardiovascular disease.
32694823	2	56	theme	underlying	564:573	arg1	mechanisms					575:584	the underlying mechanisms	560:584	the underlying mechanisms for maternal exercise to improve offspring's health	560:636	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	1	57	from	development	232:242	arg1	offspring1-9					302:313	offspring1-9	302:313	offspring1-9	302:313	Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9.
32694823	8	58	theme	cardiovascular	1745:1758	arg1	disease					1760:1766	cardiovascular disease	1745:1766	cardiovascular disease	1745:1766	3'-SL supplementation is a potential therapeutic approach to combat the development of obesity, type 2 diabetes and cardiovascular disease.
32694823	3	59	from	increase	718:725	arg1	3'-SL					768:772	3'-SL	768:772	3'-SL	768:772	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	3	59	from	increase	718:725	arg1	3'-sialyllactose					750:765	the oligosaccharide 3'-sialyllactose	730:765	the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice	730:800	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	6	60	from	effects	1419:1425	arg1	metabolism					1470:1479	metabolism	1470:1479	metabolism	1470:1479	Importantly, supplementation of 3'-SL negated the detrimental effects of a high-fat diet on body composition and metabolism.
32694823	6	60	from	effects	1419:1425	arg1	composition					1454:1464	body composition	1449:1464	body composition	1449:1464	Importantly, supplementation of 3'-SL negated the detrimental effects of a high-fat diet on body composition and metabolism.
32694823	4	61	from	function	1068:1075	arg1	mice					1080:1083	mice	1080:1083	mice	1080:1083	In global 3'-SL knockout mice (3'-SL-/-), maternal exercise training failed to improve offspring metabolic health or cardiac function in mice.
32694823	3	62	theme	mouse	864:868	arg1	health					892:897	mouse offspring's metabolic health	864:897	mouse offspring's metabolic health	864:897	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	7	63	theme	exercise	1597:1604	arg1	effects					1577:1583	the effects	1573:1583	the effects of maternal exercise on offspring's health	1573:1626	The present study reveals a critical role for the oligosaccharide 3'-SL in milk to mediate the effects of maternal exercise on offspring's health.
32694823	5	64	theme	metabolic	1288:1296	arg1	health					1298:1303	metabolic health	1288:1303	metabolic health	1288:1303	There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood.
32694823	6	65	theme	detrimental	1407:1417	arg1	effects					1419:1425	the detrimental effects	1403:1425	the detrimental effects of a high-fat diet on body composition and metabolism	1403:1479	Importantly, supplementation of 3'-SL negated the detrimental effects of a high-fat diet on body composition and metabolism.
32694823	1	66	theme	Poor	141:144	arg1	under-					177:182	under-	177:182	under-	177:182	Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9.
32694823	1	66	theme	Poor	141:144	arg1	environments					155:166	Poor maternal environments	141:166	Poor maternal environments	141:166	Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9.
32694823	1	66	theme	Poor	141:144	arg1	overnutrition					187:199	overnutrition	187:199	overnutrition	187:199	Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9.
32694823	3	67	theme	exercise	852:859	arg1	effects					832:838	the beneficial effects	817:838	the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function	817:918	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	2	68	theme	function16	510:519	arg1	development					436:446	the age-related development	420:446	the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15	420:548	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	0	69	theme	metabolic	83:91	arg1	health					93:98	metabolic health	83:98	metabolic health	83:98	Exercise-induced 3'-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring.
32694823	2	70	theme	decreased	485:493	arg1	function16					510:519	decreased cardiovascular function16	485:519	decreased cardiovascular function16	485:519	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	0	71	from	3'-sialyllactose	17:32	arg1	milk					44:47	breast milk	37:47	breast milk	37:47	Exercise-induced 3'-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring.
32694823	5	72	theme	maternal	1120:1127	arg1	exercise					1129:1136	maternal exercise	1120:1136	maternal exercise	1120:1136	There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood.
32694823	3	73	theme	beneficial	821:830	arg1	effects					832:838	the beneficial effects	817:838	the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function	817:918	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	4	74	theme	3'-SL	953:957	arg1	mice					968:971	global 3'-SL knockout mice	946:971	global 3'-SL knockout mice (3'-SL-/-)	946:982	In global 3'-SL knockout mice (3'-SL-/-), maternal exercise training failed to improve offspring metabolic health or cardiac function in mice.
32694823	4	75	theme	knockout	959:966	arg1	mice					968:971	global 3'-SL knockout mice	946:971	global 3'-SL knockout mice (3'-SL-/-)	946:982	In global 3'-SL knockout mice (3'-SL-/-), maternal exercise training failed to improve offspring metabolic health or cardiac function in mice.
32694823	3	76	theme	cardiac	903:909	arg1	function					911:918	cardiac function	903:918	cardiac function	903:918	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	3	77	from	milk	778:781	arg1	humans					786:791	humans	786:791	humans	786:791	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	3	77	from	milk	778:781	arg1	mice					797:800	mice	797:800	mice	797:800	In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL.
32694823	0	78	theme	breast	37:42	arg1	milk					44:47	breast milk	37:47	breast milk	37:47	Exercise-induced 3'-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring.
32694823	6	79	theme	high-fat	1432:1439	arg1	diet					1441:1444	a high-fat diet	1430:1444	a high-fat diet	1430:1444	Importantly, supplementation of 3'-SL negated the detrimental effects of a high-fat diet on body composition and metabolism.
32694823	2	80	theme	metabolism10-15	468:482	arg1	development					436:446	the age-related development	420:446	the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15	420:548	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	5	81	dep	was	1092:1094	arg1	whereas					1216:1222	whereas	1216:1222	whereas	1216:1222	There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood.
32694823	2	82	theme	increased	525:533	arg1	adiposity11,15					535:548	increased adiposity11,15	525:548	increased adiposity11,15	525:548	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	0	83	theme	critical	54:61	arg1	mediator					63:70	a critical mediator	52:70	a critical mediator to improve metabolic health and cardiac function in mouse offspring	52:138	Exercise-induced 3'-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring.
32694823	0	83	theme	critical	54:61	arg1	3'-sialyllactose					17:32	Exercise-induced 3'-sialyllactose	0:32	Exercise-induced 3'-sialyllactose in breast milk	0:47	Exercise-induced 3'-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring.
32694823	1	84	theme	disease	291:297	arg1	development					232:242	the development	228:242	the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9	228:313	Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9.
32694823	2	85	theme	impaired	451:458	arg1	metabolism10-15					468:482	impaired glucose metabolism10-15	451:482	impaired glucose metabolism10-15	451:482	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	2	86	theme	glucose	460:466	arg1	metabolism10-15					468:482	impaired glucose metabolism10-15	451:482	impaired glucose metabolism10-15	451:482	Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified.
32694823	4	87	theme	cardiac	1060:1066	arg1	function					1068:1075	cardiac function	1060:1075	cardiac function	1060:1075	In global 3'-SL knockout mice (3'-SL-/-), maternal exercise training failed to improve offspring metabolic health or cardiac function in mice.
34023604	0	0	theme	consortium	62:71	arg1	GYB1					73:76	consortium GYB1	62:76	consortium GYB1	62:76	Enhanced bioremediation of 2,3',4,4',5-pentachlorodiphenyl by consortium GYB1 immobilized on sodium alginate-biochar.
34023604	5	1	theme	SC-GYB1	971:977	arg1	beads					979:983	The SC-GYB1 beads	967:983	The SC-GYB1 beads	967:983	The SC-GYB1 beads could even keep considerable PCB degradation ability under 200 mg/L Cd2+ stress.
34023604	2	2	theme	novel	282:286	arg1	biphenyl					304:311	a novel polychlorinated biphenyl	280:311	a novel polychlorinated biphenyl degrading consortium GYB1 that can metabolize PCB 118	280:365	In this study, a novel polychlorinated biphenyl degrading consortium GYB1 that can metabolize PCB 118 was successfully obtained by acclimatization process.
34023604	5	3	theme	mg/L	1048:1051	arg1	stress					1058:1063	200 mg/L Cd2+ stress	1044:1063	200 mg/L Cd2+ stress	1044:1063	The SC-GYB1 beads could even keep considerable PCB degradation ability under 200 mg/L Cd2+ stress.
34023604	7	4	theme	community	1217:1225	arg1	structure					1227:1235	the community structure	1213:1235	the community structure	1213:1235	And embedding obviously altered the community structure and the key bacterial genera during the PCB removal process.
34023604	7	5	theme	PCB	1277:1279	arg1	process					1289:1295	the PCB removal process	1273:1295	the PCB removal process	1273:1295	And embedding obviously altered the community structure and the key bacterial genera during the PCB removal process.
34023604	3	6	theme	free	463:466	arg1	cells					478:482	free bacterial cells	463:482	free bacterial cells	463:482	To enhance the application performance of free bacterial cells, consortium GYB1 was immobilized with sodium alginate and biochar to prepare SC-GYB1 beads.
34023604	5	7	theme	Cd2+	1053:1056	arg1	stress					1058:1063	200 mg/L Cd2+ stress	1044:1063	200 mg/L Cd2+ stress	1044:1063	The SC-GYB1 beads could even keep considerable PCB degradation ability under 200 mg/L Cd2+ stress.
34023604	4	8	theme	%	701:701	arg1	weight					707:712	2.0% wet weight	698:712	2.0% wet weight of cells	698:721	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	9	theme	%	772:772	arg1	118					778:780	50.50% PCB 118	767:780	50.50% PCB 118	767:780	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	10	theme	alginate	675:682	arg1	content					689:695	2.0% sodium alginate (SA) content	663:695	2.0% sodium alginate (SA) content	663:695	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	10	theme	alginate	675:682	arg1	composition					626:636	the optimal composition	614:636	the optimal composition of the beads (0.2 g)	614:657	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	11	theme	50.50	767:771	arg1	%					772:772	%	772:772	%	772:772	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	12	dep	content	689:695	arg1	degrade					759:765	degrade	759:765	can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress	755:964	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	13	theme	2.0	663:665	arg1	%					666:666	%	666:666	%	666:666	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	0	14	theme	sodium	93:98	arg1	alginate-biochar					100:115	sodium alginate-biochar	93:115	sodium alginate-biochar	93:115	Enhanced bioremediation of 2,3',4,4',5-pentachlorodiphenyl by consortium GYB1 immobilized on sodium alginate-biochar.
34023604	4	15	dep	d	898:898	arg1	to					890:891	to	890:891	to	890:891	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	16	theme	2.0	698:700	arg1	%					701:701	%	701:701	%	701:701	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	17	theme	biochar	732:738	arg1	content					740:746	1.5% biochar content	727:746	1.5% biochar content	727:746	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	3	18	theme	consortium	485:494	arg1	GYB1					496:499	consortium GYB1	485:499	consortium GYB1	485:499	To enhance the application performance of free bacterial cells, consortium GYB1 was immobilized with sodium alginate and biochar to prepare SC-GYB1 beads.
34023604	4	19	theme	optimal	618:624	arg1	composition					626:636	the optimal composition	614:636	the optimal composition of the beads (0.2 g)	614:657	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	19	theme	optimal	618:624	arg1	content					689:695	2.0% sodium alginate (SA) content	663:695	2.0% sodium alginate (SA) content	663:695	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	8	20	theme	PCB	1409:1411	arg1	biodegradation					1391:1404	the biodegradation	1387:1404	the biodegradation	1387:1404	Therefore, the immobilization of bacteria consortium by sodium alginate-biochar enhanced the biodegradation of PCB 118, which will provide new insights into functional microorganisms' actual application for PCB restoration.
34023604	8	21	theme	functional	1455:1464	arg1	application					1489:1499	functional microorganisms' actual application	1455:1499	functional microorganisms' actual application for PCB restoration	1455:1519	Therefore, the immobilization of bacteria consortium by sodium alginate-biochar enhanced the biodegradation of PCB 118, which will provide new insights into functional microorganisms' actual application for PCB restoration.
34023604	4	22	from	d	898:898	arg1	GYB1					873:876	consortium GYB1	862:876	consortium GYB1 from 8.14 d to 3.79 d	862:898	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	3	23	theme	sodium	522:527	arg1	alginate					529:536	sodium alginate	522:536	sodium alginate	522:536	To enhance the application performance of free bacterial cells, consortium GYB1 was immobilized with sodium alginate and biochar to prepare SC-GYB1 beads.
34023604	2	24	theme	consortium	323:332	arg1	GYB1					334:337	consortium GYB1	323:337	consortium GYB1 that can metabolize PCB 118	323:365	In this study, a novel polychlorinated biphenyl degrading consortium GYB1 that can metabolize PCB 118 was successfully obtained by acclimatization process.
34023604	0	25	theme	Enhanced	0:7	arg1	bioremediation					9:22	Enhanced bioremediation	0:22	Enhanced bioremediation of 2,3',4,4',5-pentachlorodiphenyl by consortium GYB1	0:76	Enhanced bioremediation of 2,3',4,4',5-pentachlorodiphenyl by consortium GYB1 immobilized on sodium alginate-biochar.
34023604	4	26	theme	d	888:888	arg1	d					898:898	8.14 d to 3.79 d	883:898	8.14 d to 3.79 d	883:898	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	6	27	theme	gene	1088:1091	arg1	analysis					1093:1100	16S rRNA gene analysis	1079:1100	16S rRNA gene analysis	1079:1100	According to 16S rRNA gene analysis, Pseudomonas and Stenotrophomonas played the dominant role in consortium GYB1.
34023604	4	28	theme	sodium	668:673	arg1	content					689:695	2.0% sodium alginate (SA) content	663:695	2.0% sodium alginate (SA) content	663:695	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	28	theme	sodium	668:673	arg1	composition					626:636	the optimal composition	614:636	the optimal composition of the beads (0.2 g)	614:657	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	29	theme	environmental	945:957	arg1	stress					959:964	environmental stress	945:964	environmental stress	945:964	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	30	theme	SA	685:686	arg1	content					689:695	2.0% sodium alginate (SA) content	663:695	2.0% sodium alginate (SA) content	663:695	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	30	theme	SA	685:686	arg1	composition					626:636	the optimal composition	614:636	the optimal composition of the beads (0.2 g)	614:657	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	31	theme	d.	787:788	arg1	Immobilization					790:803	5 d. Immobilization	785:803	5 d. Immobilization	785:803	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	2	32	theme	PCB	359:361	arg1	118					363:365	PCB 118	359:365	PCB 118	359:365	In this study, a novel polychlorinated biphenyl degrading consortium GYB1 that can metabolize PCB 118 was successfully obtained by acclimatization process.
34023604	5	33	theme	200	1044:1046	arg1	mg/L					1048:1051	mg/L	1048:1051	mg/L	1048:1051	The SC-GYB1 beads could even keep considerable PCB degradation ability under 200 mg/L Cd2+ stress.
34023604	6	34	theme	16S	1079:1081	arg1	analysis					1093:1100	16S rRNA gene analysis	1079:1100	16S rRNA gene analysis	1079:1100	According to 16S rRNA gene analysis, Pseudomonas and Stenotrophomonas played the dominant role in consortium GYB1.
34023604	6	35	theme	rRNA	1083:1086	arg1	analysis					1093:1100	16S rRNA gene analysis	1079:1100	16S rRNA gene analysis	1079:1100	According to 16S rRNA gene analysis, Pseudomonas and Stenotrophomonas played the dominant role in consortium GYB1.
34023604	4	36	theme	consortium	862:871	arg1	GYB1					873:876	consortium GYB1	862:876	consortium GYB1 from 8.14 d to 3.79 d	862:898	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	37	theme	cells	717:721	arg1	weight					707:712	2.0% wet weight	698:712	2.0% wet weight of cells	698:721	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	37	theme	cells	717:721	arg1	content					689:695	2.0% sodium alginate (SA) content	663:695	2.0% sodium alginate (SA) content	663:695	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	37	theme	cells	717:721	arg1	content					740:746	1.5% biochar content	727:746	1.5% biochar content	727:746	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	37	theme	cells	717:721	arg1	composition					626:636	the optimal composition	614:636	the optimal composition of the beads (0.2 g)	614:657	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	1	38	theme	dioxin-like	163:173	arg1	PCB					175:177	a dioxin-like PCB	161:177	a dioxin-like PCB	161:177	2,3',4,4',5-pentachlorodiphenyl (PCB 118), a dioxin-like PCB, is often detected in the environment and is difficult to be aerobically biodegraded.
34023604	1	38	theme	dioxin-like	163:173	arg1	5-pentachlorodiphenyl					128:148	2,3',4,4',5-pentachlorodiphenyl	118:148	2,3',4,4',5-pentachlorodiphenyl (PCB 118)	118:158	2,3',4,4',5-pentachlorodiphenyl (PCB 118), a dioxin-like PCB, is often detected in the environment and is difficult to be aerobically biodegraded.
34023604	8	39	theme	new	1437:1439	arg1	insights					1441:1448	new insights	1437:1448	new insights into functional microorganisms' actual application for PCB restoration	1437:1519	Therefore, the immobilization of bacteria consortium by sodium alginate-biochar enhanced the biodegradation of PCB 118, which will provide new insights into functional microorganisms' actual application for PCB restoration.
34023604	6	40	theme	consortium	1164:1173	arg1	GYB1					1175:1178	consortium GYB1	1164:1178	consortium GYB1	1164:1178	According to 16S rRNA gene analysis, Pseudomonas and Stenotrophomonas played the dominant role in consortium GYB1.
34023604	7	41	theme	key	1245:1247	arg1	genera					1259:1264	the key bacterial genera	1241:1264	the key bacterial genera	1241:1264	And embedding obviously altered the community structure and the key bacterial genera during the PCB removal process.
34023604	4	42	theme	%	730:730	arg1	content					740:746	1.5% biochar content	727:746	1.5% biochar content	727:746	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	3	43	theme	application	436:446	arg1	performance					448:458	the application performance	432:458	the application performance of free bacterial cells	432:482	To enhance the application performance of free bacterial cells, consortium GYB1 was immobilized with sodium alginate and biochar to prepare SC-GYB1 beads.
34023604	2	44	theme	acclimatization	396:410	arg1	process					412:418	acclimatization process	396:418	acclimatization process	396:418	In this study, a novel polychlorinated biphenyl degrading consortium GYB1 that can metabolize PCB 118 was successfully obtained by acclimatization process.
34023604	5	45	theme	considerable	1001:1012	arg1	ability					1030:1036	considerable PCB degradation ability	1001:1036	considerable PCB degradation ability	1001:1036	The SC-GYB1 beads could even keep considerable PCB degradation ability under 200 mg/L Cd2+ stress.
34023604	4	46	theme	PCB	774:776	arg1	118					778:780	50.50% PCB 118	767:780	50.50% PCB 118	767:780	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	8	47	theme	bacteria	1331:1338	arg1	consortium					1340:1349	bacteria consortium	1331:1349	bacteria consortium	1331:1349	Therefore, the immobilization of bacteria consortium by sodium alginate-biochar enhanced the biodegradation of PCB 118, which will provide new insights into functional microorganisms' actual application for PCB restoration.
34023604	4	48	theme	1.5	727:729	arg1	%					730:730	%	730:730	%	730:730	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	49	theme	robust	924:929	arg1	beads					913:917	the beads	909:917	the beads more robust	909:929	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	5	50	theme	PCB	1014:1016	arg1	ability					1030:1036	considerable PCB degradation ability	1001:1036	considerable PCB degradation ability	1001:1036	The SC-GYB1 beads could even keep considerable PCB degradation ability under 200 mg/L Cd2+ stress.
34023604	7	51	theme	removal	1281:1287	arg1	process					1289:1295	the PCB removal process	1273:1295	the PCB removal process	1273:1295	And embedding obviously altered the community structure and the key bacterial genera during the PCB removal process.
34023604	4	52	theme	wet	703:705	arg1	weight					707:712	2.0% wet weight	698:712	2.0% wet weight of cells	698:721	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	53	theme	beads	645:649	arg1	composition					626:636	the optimal composition	614:636	the optimal composition of the beads (0.2 g)	614:657	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	53	theme	beads	645:649	arg1	content					689:695	2.0% sodium alginate (SA) content	663:695	2.0% sodium alginate (SA) content	663:695	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	1	54	theme	2,3	118:120	arg1	PCB					151:153	PCB 118	151:157	PCB 118	151:157	2,3',4,4',5-pentachlorodiphenyl (PCB 118), a dioxin-like PCB, is often detected in the environment and is difficult to be aerobically biodegraded.
34023604	1	54	theme	2,3	118:120	arg1	5-pentachlorodiphenyl					128:148	2,3',4,4',5-pentachlorodiphenyl	118:148	2,3',4,4',5-pentachlorodiphenyl (PCB 118)	118:158	2,3',4,4',5-pentachlorodiphenyl (PCB 118), a dioxin-like PCB, is often detected in the environment and is difficult to be aerobically biodegraded.
34023604	1	54	theme	2,3	118:120	arg1	PCB					175:177	a dioxin-like PCB	161:177	a dioxin-like PCB	161:177	2,3',4,4',5-pentachlorodiphenyl (PCB 118), a dioxin-like PCB, is often detected in the environment and is difficult to be aerobically biodegraded.
34023604	7	55	theme	bacterial	1249:1257	arg1	genera					1259:1264	the key bacterial genera	1241:1264	the key bacterial genera	1241:1264	And embedding obviously altered the community structure and the key bacterial genera during the PCB removal process.
34023604	6	56	theme	dominant	1147:1154	arg1	role					1156:1159	the dominant role	1143:1159	the dominant role	1143:1159	According to 16S rRNA gene analysis, Pseudomonas and Stenotrophomonas played the dominant role in consortium GYB1.
34023604	1	57	located	detected	189:196	arg2	5-pentachlorodiphenyl					128:148	2,3',4,4',5-pentachlorodiphenyl	118:148	2,3',4,4',5-pentachlorodiphenyl (PCB 118)	118:158	2,3',4,4',5-pentachlorodiphenyl (PCB 118), a dioxin-like PCB, is often detected in the environment and is difficult to be aerobically biodegraded.
34023604	1	57	located	detected	189:196	arg2	PCB					151:153	PCB 118	151:157	PCB 118	151:157	2,3',4,4',5-pentachlorodiphenyl (PCB 118), a dioxin-like PCB, is often detected in the environment and is difficult to be aerobically biodegraded.
34023604	1	57	located	detected	189:196	arg2	PCB					175:177	a dioxin-like PCB	161:177	a dioxin-like PCB	161:177	2,3',4,4',5-pentachlorodiphenyl (PCB 118), a dioxin-like PCB, is often detected in the environment and is difficult to be aerobically biodegraded.
34023604	1	57	located	detected	189:196	arg1	environment					205:215	the environment	201:215	the environment	201:215	2,3',4,4',5-pentachlorodiphenyl (PCB 118), a dioxin-like PCB, is often detected in the environment and is difficult to be aerobically biodegraded.
34023604	8	58	theme	sodium	1354:1359	arg1	alginate-biochar					1361:1376	sodium alginate-biochar	1354:1376	sodium alginate-biochar	1354:1376	Therefore, the immobilization of bacteria consortium by sodium alginate-biochar enhanced the biodegradation of PCB 118, which will provide new insights into functional microorganisms' actual application for PCB restoration.
34023604	2	59	theme	polychlorinated	288:302	arg1	biphenyl					304:311	a novel polychlorinated biphenyl	280:311	a novel polychlorinated biphenyl degrading consortium GYB1 that can metabolize PCB 118	280:365	In this study, a novel polychlorinated biphenyl degrading consortium GYB1 that can metabolize PCB 118 was successfully obtained by acclimatization process.
34023604	4	60	theme	%	666:666	arg1	content					689:695	2.0% sodium alginate (SA) content	663:695	2.0% sodium alginate (SA) content	663:695	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	60	theme	%	666:666	arg1	composition					626:636	the optimal composition	614:636	the optimal composition of the beads (0.2 g)	614:657	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	61	theme	PCB	851:853	arg1	mg/L					846:849	1 mg/L PCB 118	844:857	1 mg/L PCB 118	844:857	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	8	62	theme	consortium	1340:1349	arg1	immobilization					1313:1326	the immobilization	1309:1326	the immobilization of bacteria consortium by sodium alginate-biochar	1309:1376	Therefore, the immobilization of bacteria consortium by sodium alginate-biochar enhanced the biodegradation of PCB 118, which will provide new insights into functional microorganisms' actual application for PCB restoration.
34023604	3	63	theme	SC-GYB1	561:567	arg1	beads					569:573	SC-GYB1 beads	561:573	SC-GYB1 beads	561:573	To enhance the application performance of free bacterial cells, consortium GYB1 was immobilized with sodium alginate and biochar to prepare SC-GYB1 beads.
34023604	3	64	theme	bacterial	468:476	arg1	cells					478:482	free bacterial cells	463:482	free bacterial cells	463:482	To enhance the application performance of free bacterial cells, consortium GYB1 was immobilized with sodium alginate and biochar to prepare SC-GYB1 beads.
34023604	5	65	theme	degradation	1018:1028	arg1	ability					1030:1036	considerable PCB degradation ability	1001:1036	considerable PCB degradation ability	1001:1036	The SC-GYB1 beads could even keep considerable PCB degradation ability under 200 mg/L Cd2+ stress.
34023604	4	66	theme	Orthogonal	576:585	arg1	experiments					587:597	Orthogonal experiments	576:597	Orthogonal experiments	576:597	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	4	67	theme	mg/L	846:849	arg1	half-life					831:839	the degradation half-life	815:839	the degradation half-life of 1 mg/L PCB 118	815:857	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34023604	8	68	theme	actual	1482:1487	arg1	application					1489:1499	functional microorganisms' actual application	1455:1499	functional microorganisms' actual application for PCB restoration	1455:1519	Therefore, the immobilization of bacteria consortium by sodium alginate-biochar enhanced the biodegradation of PCB 118, which will provide new insights into functional microorganisms' actual application for PCB restoration.
34023604	3	69	theme	cells	478:482	arg1	performance					448:458	the application performance	432:458	the application performance of free bacterial cells	432:482	To enhance the application performance of free bacterial cells, consortium GYB1 was immobilized with sodium alginate and biochar to prepare SC-GYB1 beads.
34023604	4	70	theme	degradation	819:829	arg1	half-life					831:839	the degradation half-life	815:839	the degradation half-life of 1 mg/L PCB 118	815:857	Orthogonal experiments indicated that the optimal composition of the beads (0.2 g) was 2.0% sodium alginate (SA) content, 2.0% wet weight of cells and 1.5% biochar content, which can degrade 50.50% PCB 118 in 5 d. Immobilization shortened the degradation half-life of 1 mg/L PCB 118 by consortium GYB1 from 8.14 d to 3.79 d and made the beads more robust to respond to environmental stress.
34474255	7	0	theme	Cu2+	867:870	arg1	binding					876:882	Cu2+ ion binding	867:882	Cu2+ ion binding	867:882	FTIR analyzes revealed that carboxyl and hydroxyl groups play a key role in Cu2+ ion binding.
34474255	10	1	theme	release	1202:1208	arg1	study					1184:1188	The study	1180:1188	The study of Cu2+ ion release in different media	1180:1227	The study of Cu2+ ion release in different media showed that the chitosan layer slowed down the diffusion of cations by about 50% in NaNO3 (1% m/m) solution.
34474255	8	2	theme	surface	970:976	arg1	homogenization					938:951	homogenization	938:951	homogenization of the composite surface	938:976	Morphology analysis showed that ion binding leads to homogenization of the composite surface, while coating the structure makes it more regular and cohesive.
34474255	13	3	theme	nutrients	1779:1787	arg1	loss					1760:1763	the loss	1756:1763	the loss of fertilizer nutrients to the environment	1756:1806	New fertilizer formulations containing chitosan-encapsulated hydrogel with biomass-immobilized micronutrients can be applied for precision agriculture to minimize the loss of fertilizer nutrients to the environment.
34474255	10	4	theme	Cu2+	1193:1196	arg1	release					1202:1208	Cu2+ ion release	1193:1208	Cu2+ ion release	1193:1208	The study of Cu2+ ion release in different media showed that the chitosan layer slowed down the diffusion of cations by about 50% in NaNO3 (1% m/m) solution.
34474255	13	5	contain	containing	1621:1630	arg1	formulations					1608:1619	New fertilizer formulations	1593:1619	New fertilizer formulations containing chitosan-encapsulated hydrogel with biomass-immobilized micronutrients	1593:1701	New fertilizer formulations containing chitosan-encapsulated hydrogel with biomass-immobilized micronutrients can be applied for precision agriculture to minimize the loss of fertilizer nutrients to the environment.
34474255	13	5	contain	containing	1621:1630	arg2	hydrogel					1654:1661	chitosan-encapsulated hydrogel	1632:1661	chitosan-encapsulated hydrogel with biomass-immobilized micronutrients	1632:1701	New fertilizer formulations containing chitosan-encapsulated hydrogel with biomass-immobilized micronutrients can be applied for precision agriculture to minimize the loss of fertilizer nutrients to the environment.
34474255	13	6	theme	precision	1722:1730	arg1	agriculture					1732:1742	precision agriculture	1722:1742	precision agriculture	1722:1742	New fertilizer formulations containing chitosan-encapsulated hydrogel with biomass-immobilized micronutrients can be applied for precision agriculture to minimize the loss of fertilizer nutrients to the environment.
34474255	10	7	from	study	1184:1188	arg1	media					1223:1227	different media	1213:1227	different media	1213:1227	The study of Cu2+ ion release in different media showed that the chitosan layer slowed down the diffusion of cations by about 50% in NaNO3 (1% m/m) solution.
34474255	11	8	from	applicability	1365:1377	arg1	tests					1410:1414	germination tests	1398:1414	germination tests	1398:1414	Preliminary studies of the applicability of the capsules in germination tests demonstrate that the biocomposites have no phytotoxic effects on the test plant.
34474255	5	9	theme	certain	541:547	arg1	influence					549:557	a certain influence	539:557	a certain influence	539:557	The amount of components exerts a certain influence on the effectiveness of copper ions binding.
34474255	13	10	theme	fertilizer	1768:1777	arg1	nutrients					1779:1787	fertilizer nutrients	1768:1787	fertilizer nutrients	1768:1787	New fertilizer formulations containing chitosan-encapsulated hydrogel with biomass-immobilized micronutrients can be applied for precision agriculture to minimize the loss of fertilizer nutrients to the environment.
34474255	2	11	theme	waste	219:223	arg1	sector					185:190	The agri-food sector	171:190	The agri-food sector	171:190	The agri-food sector is the largest producer of waste and requires the extensive use of fertilizers, which entails the need to look for innovative solutions in waste management.
34474255	2	11	theme	waste	219:223	arg1	producer					207:214	the largest producer	195:214	the largest producer of waste	195:223	The agri-food sector is the largest producer of waste and requires the extensive use of fertilizers, which entails the need to look for innovative solutions in waste management.
34474255	12	12	theme	ions	1544:1547	arg1	release					1528:1534	the release	1524:1534	the release of Cu2+ ions	1524:1547	The chitosan coating slows the release of Cu2+ ions by about 20% compared to uncoated capsules.
34474255	11	13	theme	phytotoxic	1459:1468	arg1	effects					1470:1476	no phytotoxic effects	1456:1476	no phytotoxic effects	1456:1476	Preliminary studies of the applicability of the capsules in germination tests demonstrate that the biocomposites have no phytotoxic effects on the test plant.
34474255	1	14	theme	environmental	127:139	arg1	amount					105:110	The tremendous amount	90:110	The tremendous amount of waste	90:119	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	1	14	theme	environmental	127:139	arg1	worldwide					160:168	an environmental and social problem worldwide	124:168	an environmental and social problem worldwide	124:168	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	1	14	theme	environmental	127:139	arg1	waste					115:119	waste	115:119	waste	115:119	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	4	15	theme	immobilized	428:438	arg1	biomass					446:452	immobilized waste biomass	428:452	immobilized waste biomass	428:452	Polymer capsules with immobilized waste biomass can be applied as carriers for fertilizer nutrients.
34474255	10	16	theme	different	1213:1221	arg1	media					1223:1227	different media	1213:1227	different media	1213:1227	The study of Cu2+ ion release in different media showed that the chitosan layer slowed down the diffusion of cations by about 50% in NaNO3 (1% m/m) solution.
34474255	0	17	theme	biocomposite	64:75	arg1	fertilizers					77:87	hydrogel biocomposite fertilizers	55:87	hydrogel biocomposite fertilizers	55:87	New directions for agricultural wastes valorization as hydrogel biocomposite fertilizers.
34474255	2	18	theme	extensive	242:250	arg1	use					252:254	the extensive use	238:254	the extensive use	238:254	The agri-food sector is the largest producer of waste and requires the extensive use of fertilizers, which entails the need to look for innovative solutions in waste management.
34474255	1	19	theme	problem	152:158	arg1	amount					105:110	The tremendous amount	90:110	The tremendous amount of waste	90:119	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	1	19	theme	problem	152:158	arg1	worldwide					160:168	an environmental and social problem worldwide	124:168	an environmental and social problem worldwide	124:168	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	1	19	theme	problem	152:158	arg1	waste					115:119	waste	115:119	waste	115:119	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	11	20	theme	test	1485:1488	arg1	plant					1490:1494	the test plant	1481:1494	the test plant	1481:1494	Preliminary studies of the applicability of the capsules in germination tests demonstrate that the biocomposites have no phytotoxic effects on the test plant.
34474255	5	21	theme	binding	595:601	arg1	ions					590:593	copper ions binding	583:601	copper ions binding	583:601	The amount of components exerts a certain influence on the effectiveness of copper ions binding.
34474255	6	22	theme	important	613:621	arg1	properties					639:648	The most important physicochemical properties	604:648	The most important physicochemical properties of biocomposites, such as swelling, SEM (Scanning Electron Microscopy) and FTIR (Fourier Transform Infrared Spectroscopy)	604:770	The most important physicochemical properties of biocomposites, such as swelling, SEM (Scanning Electron Microscopy) and FTIR (Fourier Transform Infrared Spectroscopy) were investigated.
34474255	13	23	theme	chitosan-encapsulated	1632:1652	arg1	hydrogel					1654:1661	chitosan-encapsulated hydrogel	1632:1661	chitosan-encapsulated hydrogel with biomass-immobilized micronutrients	1632:1701	New fertilizer formulations containing chitosan-encapsulated hydrogel with biomass-immobilized micronutrients can be applied for precision agriculture to minimize the loss of fertilizer nutrients to the environment.
34474255	11	24	theme	germination	1398:1408	arg1	tests					1410:1414	germination tests	1398:1414	germination tests	1398:1414	Preliminary studies of the applicability of the capsules in germination tests demonstrate that the biocomposites have no phytotoxic effects on the test plant.
34474255	10	25	from	%	1308:1308	arg1	solution					1328:1335	NaNO3 (1% m/m) solution	1313:1335	NaNO3 (1% m/m) solution	1313:1335	The study of Cu2+ ion release in different media showed that the chitosan layer slowed down the diffusion of cations by about 50% in NaNO3 (1% m/m) solution.
34474255	6	26	theme	Scanning	691:698	arg1	SEM					686:688	SEM	686:688	SEM (Scanning Electron Microscopy)	686:719	The most important physicochemical properties of biocomposites, such as swelling, SEM (Scanning Electron Microscopy) and FTIR (Fourier Transform Infrared Spectroscopy) were investigated.
34474255	6	26	theme	Scanning	691:698	arg1	Microscopy					709:718	Scanning Electron Microscopy	691:718	Scanning Electron Microscopy	691:718	The most important physicochemical properties of biocomposites, such as swelling, SEM (Scanning Electron Microscopy) and FTIR (Fourier Transform Infrared Spectroscopy) were investigated.
34474255	0	27	theme	New	0:2	arg1	directions					4:13	New directions	0:13	New directions for agricultural wastes	0:37	New directions for agricultural wastes valorization as hydrogel biocomposite fertilizers.
34474255	5	28	theme	copper	583:588	arg1	ions					590:593	copper ions binding	583:601	copper ions binding	583:601	The amount of components exerts a certain influence on the effectiveness of copper ions binding.
34474255	12	29	theme	uncoated	1574:1581	arg1	capsules					1583:1590	uncoated capsules	1574:1590	uncoated capsules	1574:1590	The chitosan coating slows the release of Cu2+ ions by about 20% compared to uncoated capsules.
34474255	13	30	theme	New	1593:1595	arg1	formulations					1608:1619	New fertilizer formulations	1593:1619	New fertilizer formulations containing chitosan-encapsulated hydrogel with biomass-immobilized micronutrients	1593:1701	New fertilizer formulations containing chitosan-encapsulated hydrogel with biomass-immobilized micronutrients can be applied for precision agriculture to minimize the loss of fertilizer nutrients to the environment.
34474255	1	31	theme	waste	115:119	arg1	amount					105:110	The tremendous amount	90:110	The tremendous amount of waste	90:119	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	1	31	theme	waste	115:119	arg1	worldwide					160:168	an environmental and social problem worldwide	124:168	an environmental and social problem worldwide	124:168	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	1	31	theme	waste	115:119	arg1	waste					115:119	waste	115:119	waste	115:119	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	9	32	theme	equilibrium	1104:1114	arg1	Qmax = 29.4 ± 0.493 mg g-1					1128:1153	Qmax = 29.4 ± 0.493 mg g-1	1128:1153	Qmax = 29.4 ± 0.493 mg g-1	1128:1153	The sorption kinetics and the determination of the process's equilibrium parameters (Qmax = 29.4 ± 0.493 mg g-1) play an important role.
34474255	9	32	theme	equilibrium	1104:1114	arg1	parameters					1116:1125	the process's equilibrium parameters	1090:1125	the process's equilibrium parameters (Qmax = 29.4 ± 0.493 mg g-1)	1090:1154	The sorption kinetics and the determination of the process's equilibrium parameters (Qmax = 29.4 ± 0.493 mg g-1) play an important role.
34474255	10	33	theme	NaNO3	1313:1317	arg1	solution					1328:1335	NaNO3 (1% m/m) solution	1313:1335	NaNO3 (1% m/m) solution	1313:1335	The study of Cu2+ ion release in different media showed that the chitosan layer slowed down the diffusion of cations by about 50% in NaNO3 (1% m/m) solution.
34474255	2	34	theme	waste	331:335	arg1	management					337:346	waste management	331:346	waste management	331:346	The agri-food sector is the largest producer of waste and requires the extensive use of fertilizers, which entails the need to look for innovative solutions in waste management.
34474255	11	35	contain	have	1451:1454	arg1	biocomposites					1437:1449	the biocomposites	1433:1449	the biocomposites	1433:1449	Preliminary studies of the applicability of the capsules in germination tests demonstrate that the biocomposites have no phytotoxic effects on the test plant.
34474255	11	35	contain	have	1451:1454	arg2	effects					1470:1476	no phytotoxic effects	1456:1476	no phytotoxic effects	1456:1476	Preliminary studies of the applicability of the capsules in germination tests demonstrate that the biocomposites have no phytotoxic effects on the test plant.
34474255	6	36	dep	FTIR	725:728	arg1	Transform					739:747	Transform	739:747	Transform Infrared Spectroscopy	739:769	The most important physicochemical properties of biocomposites, such as swelling, SEM (Scanning Electron Microscopy) and FTIR (Fourier Transform Infrared Spectroscopy) were investigated.
34474255	11	37	from	capsules	1386:1393	arg1	tests					1410:1414	germination tests	1398:1414	germination tests	1398:1414	Preliminary studies of the applicability of the capsules in germination tests demonstrate that the biocomposites have no phytotoxic effects on the test plant.
34474255	11	38	theme	Preliminary	1338:1348	arg1	studies					1350:1356	Preliminary studies	1338:1356	Preliminary studies of the applicability of the capsules in germination tests	1338:1414	Preliminary studies of the applicability of the capsules in germination tests demonstrate that the biocomposites have no phytotoxic effects on the test plant.
34474255	8	39	theme	composite	960:968	arg1	surface					970:976	the composite surface	956:976	the composite surface	956:976	Morphology analysis showed that ion binding leads to homogenization of the composite surface, while coating the structure makes it more regular and cohesive.
34474255	2	40	from	solutions	318:326	arg1	management					337:346	waste management	331:346	waste management	331:346	The agri-food sector is the largest producer of waste and requires the extensive use of fertilizers, which entails the need to look for innovative solutions in waste management.
34474255	11	41	theme	applicability	1365:1377	arg1	studies					1350:1356	Preliminary studies	1338:1356	Preliminary studies of the applicability of the capsules in germination tests	1338:1414	Preliminary studies of the applicability of the capsules in germination tests demonstrate that the biocomposites have no phytotoxic effects on the test plant.
34474255	7	42	theme	ion	872:874	arg1	binding					876:882	Cu2+ ion binding	867:882	Cu2+ ion binding	867:882	FTIR analyzes revealed that carboxyl and hydroxyl groups play a key role in Cu2+ ion binding.
34474255	10	43	theme	ion	1198:1200	arg1	release					1202:1208	Cu2+ ion release	1193:1208	Cu2+ ion release	1193:1208	The study of Cu2+ ion release in different media showed that the chitosan layer slowed down the diffusion of cations by about 50% in NaNO3 (1% m/m) solution.
34474255	4	44	theme	Polymer	406:412	arg1	capsules					414:421	Polymer capsules	406:421	Polymer capsules with immobilized waste biomass	406:452	Polymer capsules with immobilized waste biomass can be applied as carriers for fertilizer nutrients.
34474255	4	44	theme	Polymer	406:412	arg1	carriers					472:479	carriers	472:479	carriers for fertilizer nutrients	472:504	Polymer capsules with immobilized waste biomass can be applied as carriers for fertilizer nutrients.
34474255	7	45	theme	key	855:857	arg1	role					859:862	a key role	853:862	a key role	853:862	FTIR analyzes revealed that carboxyl and hydroxyl groups play a key role in Cu2+ ion binding.
34474255	9	46	theme	sorption	1047:1054	arg1	kinetics					1056:1063	The sorption kinetics	1043:1063	The sorption kinetics	1043:1063	The sorption kinetics and the determination of the process's equilibrium parameters (Qmax = 29.4 ± 0.493 mg g-1) play an important role.
34474255	7	47	theme	hydroxyl	832:839	arg1	groups					841:846	hydroxyl groups	832:846	hydroxyl groups	832:846	FTIR analyzes revealed that carboxyl and hydroxyl groups play a key role in Cu2+ ion binding.
34474255	12	48	theme	Cu2+	1539:1542	arg1	ions					1544:1547	Cu2+ ions	1539:1547	Cu2+ ions	1539:1547	The chitosan coating slows the release of Cu2+ ions by about 20% compared to uncoated capsules.
34474255	10	49	theme	cations	1289:1295	arg1	diffusion					1276:1284	the diffusion	1272:1284	the diffusion of cations	1272:1295	The study of Cu2+ ion release in different media showed that the chitosan layer slowed down the diffusion of cations by about 50% in NaNO3 (1% m/m) solution.
34474255	14	50	theme	greenhouse	1870:1879	arg1	crops					1881:1885	houseplants and greenhouse crops	1854:1885	houseplants and greenhouse crops	1854:1885	These fertilizers could be used to cultivate houseplants and greenhouse crops.
34474255	2	51	theme	fertilizers	259:269	arg1	use					252:254	the extensive use	238:254	the extensive use	238:254	The agri-food sector is the largest producer of waste and requires the extensive use of fertilizers, which entails the need to look for innovative solutions in waste management.
34474255	14	52	theme	houseplants	1854:1864	arg1	crops					1881:1885	houseplants and greenhouse crops	1854:1885	houseplants and greenhouse crops	1854:1885	These fertilizers could be used to cultivate houseplants and greenhouse crops.
34474255	4	53	theme	waste	440:444	arg1	biomass					446:452	immobilized waste biomass	428:452	immobilized waste biomass	428:452	Polymer capsules with immobilized waste biomass can be applied as carriers for fertilizer nutrients.
34474255	13	54	with	hydrogel	1654:1661	arg1	micronutrients					1688:1701	biomass-immobilized micronutrients	1668:1701	biomass-immobilized micronutrients	1668:1701	New fertilizer formulations containing chitosan-encapsulated hydrogel with biomass-immobilized micronutrients can be applied for precision agriculture to minimize the loss of fertilizer nutrients to the environment.
34474255	14	55	used	used	1836:1839	arg2	fertilizers					1815:1825	These fertilizers	1809:1825	These fertilizers	1809:1825	These fertilizers could be used to cultivate houseplants and greenhouse crops.
34474255	5	56	theme	components	521:530	arg1	components					521:530	components	521:530	components	521:530	The amount of components exerts a certain influence on the effectiveness of copper ions binding.
34474255	5	56	theme	components	521:530	arg1	amount					511:516	The amount	507:516	The amount of components	507:530	The amount of components exerts a certain influence on the effectiveness of copper ions binding.
34474255	1	57	theme	social	145:150	arg1	amount					105:110	The tremendous amount	90:110	The tremendous amount of waste	90:119	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	1	57	theme	social	145:150	arg1	worldwide					160:168	an environmental and social problem worldwide	124:168	an environmental and social problem worldwide	124:168	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	1	57	theme	social	145:150	arg1	waste					115:119	waste	115:119	waste	115:119	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	6	58	theme	biocomposites	653:665	arg1	properties					639:648	The most important physicochemical properties	604:648	The most important physicochemical properties of biocomposites, such as swelling, SEM (Scanning Electron Microscopy) and FTIR (Fourier Transform Infrared Spectroscopy)	604:770	The most important physicochemical properties of biocomposites, such as swelling, SEM (Scanning Electron Microscopy) and FTIR (Fourier Transform Infrared Spectroscopy) were investigated.
34474255	8	59	theme	regular	1021:1027	arg1	structure					997:1005	the structure	993:1005	the structure makes it more regular and cohesive	993:1040	Morphology analysis showed that ion binding leads to homogenization of the composite surface, while coating the structure makes it more regular and cohesive.
34474255	6	60	theme	physicochemical	623:637	arg1	properties					639:648	The most important physicochemical properties	604:648	The most important physicochemical properties of biocomposites, such as swelling, SEM (Scanning Electron Microscopy) and FTIR (Fourier Transform Infrared Spectroscopy)	604:770	The most important physicochemical properties of biocomposites, such as swelling, SEM (Scanning Electron Microscopy) and FTIR (Fourier Transform Infrared Spectroscopy) were investigated.
34474255	8	61	theme	cohesive	1033:1040	arg1	structure					997:1005	the structure	993:1005	the structure makes it more regular and cohesive	993:1040	Morphology analysis showed that ion binding leads to homogenization of the composite surface, while coating the structure makes it more regular and cohesive.
34474255	12	62	theme	chitosan	1501:1508	arg1	coating					1510:1516	The chitosan coating	1497:1516	The chitosan coating	1497:1516	The chitosan coating slows the release of Cu2+ ions by about 20% compared to uncoated capsules.
34474255	3	63	theme	recycled	358:365	arg1	fertilizer					394:403	fertilizer	394:403	fertilizer	394:403	Properly recycled bio-waste can be reused as fertilizer.
34474255	3	63	theme	recycled	358:365	arg1	bio-waste					367:375	Properly recycled bio-waste	349:375	Properly recycled bio-waste	349:375	Properly recycled bio-waste can be reused as fertilizer.
34474255	4	64	theme	fertilizer	485:494	arg1	nutrients					496:504	fertilizer nutrients	485:504	fertilizer nutrients	485:504	Polymer capsules with immobilized waste biomass can be applied as carriers for fertilizer nutrients.
34474255	6	65	theme	Electron	700:707	arg1	SEM					686:688	SEM	686:688	SEM (Scanning Electron Microscopy)	686:719	The most important physicochemical properties of biocomposites, such as swelling, SEM (Scanning Electron Microscopy) and FTIR (Fourier Transform Infrared Spectroscopy) were investigated.
34474255	6	65	theme	Electron	700:707	arg1	Microscopy					709:718	Scanning Electron Microscopy	691:718	Scanning Electron Microscopy	691:718	The most important physicochemical properties of biocomposites, such as swelling, SEM (Scanning Electron Microscopy) and FTIR (Fourier Transform Infrared Spectroscopy) were investigated.
34474255	1	66	theme	tremendous	94:103	arg1	amount					105:110	The tremendous amount	90:110	The tremendous amount of waste	90:119	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	1	66	theme	tremendous	94:103	arg1	worldwide					160:168	an environmental and social problem worldwide	124:168	an environmental and social problem worldwide	124:168	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	1	66	theme	tremendous	94:103	arg1	waste					115:119	waste	115:119	waste	115:119	The tremendous amount of waste is an environmental and social problem worldwide.
34474255	13	67	theme	biomass-immobilized	1668:1686	arg1	micronutrients					1688:1701	biomass-immobilized micronutrients	1668:1701	biomass-immobilized micronutrients	1668:1701	New fertilizer formulations containing chitosan-encapsulated hydrogel with biomass-immobilized micronutrients can be applied for precision agriculture to minimize the loss of fertilizer nutrients to the environment.
34474255	0	68	theme	agricultural	19:30	arg1	wastes					32:37	agricultural wastes	19:37	agricultural wastes	19:37	New directions for agricultural wastes valorization as hydrogel biocomposite fertilizers.
34474255	5	69	theme	ions	590:593	arg1	effectiveness					566:578	the effectiveness	562:578	the effectiveness of copper ions binding	562:601	The amount of components exerts a certain influence on the effectiveness of copper ions binding.
34474255	8	70	theme	Morphology	885:894	arg1	analysis					896:903	Morphology analysis	885:903	Morphology analysis	885:903	Morphology analysis showed that ion binding leads to homogenization of the composite surface, while coating the structure makes it more regular and cohesive.
34474255	13	71	theme	fertilizer	1597:1606	arg1	formulations					1608:1619	New fertilizer formulations	1593:1619	New fertilizer formulations containing chitosan-encapsulated hydrogel with biomass-immobilized micronutrients	1593:1701	New fertilizer formulations containing chitosan-encapsulated hydrogel with biomass-immobilized micronutrients can be applied for precision agriculture to minimize the loss of fertilizer nutrients to the environment.
34474255	11	72	from	tests	1410:1414	arg1	applicability					1365:1377	the applicability	1361:1377	the applicability of the capsules in germination tests	1361:1414	Preliminary studies of the applicability of the capsules in germination tests demonstrate that the biocomposites have no phytotoxic effects on the test plant.
34474255	2	73	theme	agri-food	175:183	arg1	sector					185:190	The agri-food sector	171:190	The agri-food sector	171:190	The agri-food sector is the largest producer of waste and requires the extensive use of fertilizers, which entails the need to look for innovative solutions in waste management.
34474255	2	73	theme	agri-food	175:183	arg1	producer					207:214	the largest producer	195:214	the largest producer of waste	195:223	The agri-food sector is the largest producer of waste and requires the extensive use of fertilizers, which entails the need to look for innovative solutions in waste management.
34474255	9	74	theme	parameters	1116:1125	arg1	determination					1073:1085	the determination	1069:1085	the determination of the process's equilibrium parameters (Qmax = 29.4 ± 0.493 mg g-1)	1069:1154	The sorption kinetics and the determination of the process's equilibrium parameters (Qmax = 29.4 ± 0.493 mg g-1) play an important role.
34474255	9	74	theme	parameters	1116:1125	arg1	kinetics					1056:1063	The sorption kinetics	1043:1063	The sorption kinetics	1043:1063	The sorption kinetics and the determination of the process's equilibrium parameters (Qmax = 29.4 ± 0.493 mg g-1) play an important role.
34474255	4	75	with	capsules	414:421	arg1	biomass					446:452	immobilized waste biomass	428:452	immobilized waste biomass	428:452	Polymer capsules with immobilized waste biomass can be applied as carriers for fertilizer nutrients.
34474255	0	76	theme	hydrogel	55:62	arg1	fertilizers					77:87	hydrogel biocomposite fertilizers	55:87	hydrogel biocomposite fertilizers	55:87	New directions for agricultural wastes valorization as hydrogel biocomposite fertilizers.
34474255	7	77	theme	FTIR	791:794	arg1	analyzes					796:803	FTIR analyzes	791:803	FTIR analyzes	791:803	FTIR analyzes revealed that carboxyl and hydroxyl groups play a key role in Cu2+ ion binding.
34474255	8	78	theme	ion	917:919	arg1	binding					921:927	ion binding	917:927	ion binding	917:927	Morphology analysis showed that ion binding leads to homogenization of the composite surface, while coating the structure makes it more regular and cohesive.
34474255	11	79	theme	capsules	1386:1393	arg1	applicability					1365:1377	the applicability	1361:1377	the applicability of the capsules in germination tests	1361:1414	Preliminary studies of the applicability of the capsules in germination tests demonstrate that the biocomposites have no phytotoxic effects on the test plant.
34474255	6	80	theme	Infrared	749:756	arg1	Spectroscopy					758:769	Infrared Spectroscopy	749:769	Infrared Spectroscopy	749:769	The most important physicochemical properties of biocomposites, such as swelling, SEM (Scanning Electron Microscopy) and FTIR (Fourier Transform Infrared Spectroscopy) were investigated.
34474255	9	81	theme	important	1164:1172	arg1	role					1174:1177	an important role	1161:1177	an important role	1161:1177	The sorption kinetics and the determination of the process's equilibrium parameters (Qmax = 29.4 ± 0.493 mg g-1) play an important role.
34474255	10	82	theme	chitosan	1245:1252	arg1	layer					1254:1258	the chitosan layer	1241:1258	the chitosan layer	1241:1258	The study of Cu2+ ion release in different media showed that the chitosan layer slowed down the diffusion of cations by about 50% in NaNO3 (1% m/m) solution.
34474255	2	83	theme	largest	199:205	arg1	sector					185:190	The agri-food sector	171:190	The agri-food sector	171:190	The agri-food sector is the largest producer of waste and requires the extensive use of fertilizers, which entails the need to look for innovative solutions in waste management.
34474255	2	83	theme	largest	199:205	arg1	producer					207:214	the largest producer	195:214	the largest producer of waste	195:223	The agri-food sector is the largest producer of waste and requires the extensive use of fertilizers, which entails the need to look for innovative solutions in waste management.
34474255	2	84	theme	innovative	307:316	arg1	solutions					318:326	innovative solutions	307:326	innovative solutions in waste management	307:346	The agri-food sector is the largest producer of waste and requires the extensive use of fertilizers, which entails the need to look for innovative solutions in waste management.
34474255	8	85	dep	structure	997:1005	arg1	makes					1007:1011	makes	1007:1011	makes it	1007:1014	Morphology analysis showed that ion binding leads to homogenization of the composite surface, while coating the structure makes it more regular and cohesive.
34474255	10	86	theme	%	1321:1321	arg1	NaNO3					1313:1317	NaNO3	1313:1317	NaNO3 (1% m/m) solution	1313:1335	The study of Cu2+ ion release in different media showed that the chitosan layer slowed down the diffusion of cations by about 50% in NaNO3 (1% m/m) solution.
34474255	10	86	theme	%	1321:1321	arg1	m/m					1323:1325	1% m/m	1320:1325	1% m/m	1320:1325	The study of Cu2+ ion release in different media showed that the chitosan layer slowed down the diffusion of cations by about 50% in NaNO3 (1% m/m) solution.
33571595	5	0	theme	new	1100:1102	arg1	ingredient					1120:1129	a new functional food ingredient	1098:1129	a new functional food ingredient to prevent obesity	1098:1148	The results indicated that the physical forms of dietary fiber are closely associated with its health benefits, and MC might be served as a new functional food ingredient to prevent obesity.
33571595	2	1	theme	body	510:513	arg1	gain					522:525	the body weight gain	506:525	the body weight gain induced by the HF diet	506:548	Supplementation of MC in high fat (HF) diet to mice for 10 weeks significantly reversed the body weight gain induced by the HF diet, along with less fat accumulation in both livers and the epididymal adipose than the PM group.
33571595	1	2	link	cross-linked	247:258	arg1	arabinoxylan					260:271	cross-linked arabinoxylan	247:271	cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC)	247:308	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	2	link	cross-linked	247:258	arg1	CAX					274:276	CAX	274:276	CAX	274:276	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	3	dep	arabinoxylan	210:221	arg1	AX					224:225	AX	224:225	AX	224:225	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	3	4	theme	microbiota	710:719	arg1	composition					721:731	the gut microbiota composition	702:731	the gut microbiota composition	702:731	Microbiome analysis showed that MC significantly altered the gut microbiota composition with a noticeable increase of butyrogenic bacteria of Lachnospiraceae.
33571595	0	5	from	arabinoxylan	13:24	arg1	matrix					45:50	a Ca2+-alginate matrix	29:50	a Ca2+-alginate matrix	29:50	Cross-linked arabinoxylan in a Ca2+-alginate matrix reversed the body weight gain of HFD-fed C57BL/6J mice through modulation of the gut microbiome.
33571595	1	6	theme	gut	358:360	arg1	microbiota					362:371	gut microbiota	358:371	gut microbiota	358:371	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	7	from	microbiota	362:371	arg1	mice					412:415	C57BL/6J mice	403:415	C57BL/6J mice	403:415	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	5	8	theme	fiber	1017:1021	arg1	forms					1000:1004	the physical forms	987:1004	the physical forms of dietary fiber	987:1021	The results indicated that the physical forms of dietary fiber are closely associated with its health benefits, and MC might be served as a new functional food ingredient to prevent obesity.
33571595	2	9	theme	MC	437:438	arg1	Supplementation					418:432	Supplementation	418:432	Supplementation of MC in high fat (HF) diet to mice for 10 weeks	418:481	Supplementation of MC in high fat (HF) diet to mice for 10 weeks significantly reversed the body weight gain induced by the HF diet, along with less fat accumulation in both livers and the epididymal adipose than the PM group.
33571595	0	10	theme	C57BL/6J	93:100	arg1	mice					102:105	HFD-fed C57BL/6J mice	85:105	HFD-fed C57BL/6J mice	85:105	Cross-linked arabinoxylan in a Ca2+-alginate matrix reversed the body weight gain of HFD-fed C57BL/6J mice through modulation of the gut microbiome.
33571595	3	11	theme	butyrogenic	763:773	arg1	bacteria					775:782	butyrogenic bacteria	763:782	butyrogenic bacteria of Lachnospiraceae	763:801	Microbiome analysis showed that MC significantly altered the gut microbiota composition with a noticeable increase of butyrogenic bacteria of Lachnospiraceae.
33571595	4	12	theme	increased	853:861	arg1	mechanism					916:924	the underlying mechanism	901:924	the underlying mechanism of the anti-obesity effect of MC	901:957	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	4	12	theme	increased	853:861	arg1	butyrate					808:815	The butyrate	804:815	The butyrate produced by MC fermentation	804:843	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	4	12	theme	increased	853:861	arg1	abundance					863:871	the increased abundance	849:871	the increased abundance of Lachnospiraceae	849:890	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	0	13	theme	HFD-fed	85:91	arg1	mice					102:105	HFD-fed C57BL/6J mice	85:105	HFD-fed C57BL/6J mice	85:105	Cross-linked arabinoxylan in a Ca2+-alginate matrix reversed the body weight gain of HFD-fed C57BL/6J mice through modulation of the gut microbiome.
33571595	5	14	theme	health	1055:1060	arg1	benefits					1062:1069	its health benefits	1051:1069	its health benefits	1051:1069	The results indicated that the physical forms of dietary fiber are closely associated with its health benefits, and MC might be served as a new functional food ingredient to prevent obesity.
33571595	2	15	theme	HF	542:543	arg1	diet					545:548	the HF diet	538:548	the HF diet	538:548	Supplementation of MC in high fat (HF) diet to mice for 10 weeks significantly reversed the body weight gain induced by the HF diet, along with less fat accumulation in both livers and the epididymal adipose than the PM group.
33571595	4	16	theme	Lachnospiraceae	876:890	arg1	abundance					863:871	the increased abundance	849:871	the increased abundance of Lachnospiraceae	849:890	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	4	16	theme	Lachnospiraceae	876:890	arg1	mechanism					916:924	the underlying mechanism	901:924	the underlying mechanism of the anti-obesity effect of MC	901:957	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	4	16	theme	Lachnospiraceae	876:890	arg1	butyrate					808:815	The butyrate	804:815	The butyrate produced by MC fermentation	804:843	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	1	17	theme	microsphere	232:242	arg1	forms					201:205	different physical forms	182:205	different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM)	182:353	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	18	from	arabinoxylan	260:271	arg1	MC					306:307	MC	306:307	MC	306:307	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	18	from	arabinoxylan	260:271	arg1	matrix					298:303	a Ca2+-alginate matrix	282:303	a Ca2+-alginate matrix (MC)	282:308	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	0	19	link	Cross-linked	0:11	arg1	arabinoxylan					13:24	Cross-linked arabinoxylan	0:24	Cross-linked arabinoxylan in a Ca2+-alginate matrix	0:50	Cross-linked arabinoxylan in a Ca2+-alginate matrix reversed the body weight gain of HFD-fed C57BL/6J mice through modulation of the gut microbiome.
33571595	2	20	theme	PM	635:636	arg1	group					638:642	the PM group	631:642	the PM group	631:642	Supplementation of MC in high fat (HF) diet to mice for 10 weeks significantly reversed the body weight gain induced by the HF diet, along with less fat accumulation in both livers and the epididymal adipose than the PM group.
33571595	5	21	theme	physical	991:998	arg1	forms					1000:1004	the physical forms	987:1004	the physical forms of dietary fiber	987:1021	The results indicated that the physical forms of dietary fiber are closely associated with its health benefits, and MC might be served as a new functional food ingredient to prevent obesity.
33571595	0	22	theme	mice	102:105	arg1	gain					77:80	the body weight gain	61:80	the body weight gain of HFD-fed C57BL/6J mice	61:105	Cross-linked arabinoxylan in a Ca2+-alginate matrix reversed the body weight gain of HFD-fed C57BL/6J mice through modulation of the gut microbiome.
33571595	1	23	theme	physical	314:321	arg1	mixture					323:329	physical mixture	314:329	physical mixture of AX and alginate (PM)	314:353	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	5	24	theme	food	1115:1118	arg1	ingredient					1120:1129	a new functional food ingredient	1098:1129	a new functional food ingredient to prevent obesity	1098:1148	The results indicated that the physical forms of dietary fiber are closely associated with its health benefits, and MC might be served as a new functional food ingredient to prevent obesity.
33571595	2	25	theme	fat	567:569	arg1	accumulation					571:582	less fat accumulation	562:582	less fat accumulation in both livers	562:597	Supplementation of MC in high fat (HF) diet to mice for 10 weeks significantly reversed the body weight gain induced by the HF diet, along with less fat accumulation in both livers and the epididymal adipose than the PM group.
33571595	1	26	from	mixture	323:329	arg1	MC					306:307	MC	306:307	MC	306:307	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	26	from	mixture	323:329	arg1	matrix					298:303	a Ca2+-alginate matrix	282:303	a Ca2+-alginate matrix (MC)	282:308	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	3	27	theme	Lachnospiraceae	787:801	arg1	bacteria					775:782	butyrogenic bacteria	763:782	butyrogenic bacteria of Lachnospiraceae	763:801	Microbiome analysis showed that MC significantly altered the gut microbiota composition with a noticeable increase of butyrogenic bacteria of Lachnospiraceae.
33571595	2	28	from	accumulation	571:582	arg1	livers					592:597	both livers	587:597	both livers	587:597	Supplementation of MC in high fat (HF) diet to mice for 10 weeks significantly reversed the body weight gain induced by the HF diet, along with less fat accumulation in both livers and the epididymal adipose than the PM group.
33571595	4	29	theme	anti-obesity	933:944	arg1	effect					946:951	the anti-obesity effect	929:951	the anti-obesity effect of MC	929:957	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	1	30	theme	mixture	323:329	arg1	microsphere					232:242	a microsphere	230:242	a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM)	230:353	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	31	theme	obesity	392:398	arg1	development					377:387	development	377:387	development of obesity in C57BL/6J mice	377:415	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	31	theme	obesity	392:398	arg1	microbiota					362:371	gut microbiota	358:371	gut microbiota	358:371	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	0	32	theme	Cross-linked	0:11	arg1	arabinoxylan					13:24	Cross-linked arabinoxylan	0:24	Cross-linked arabinoxylan in a Ca2+-alginate matrix	0:50	Cross-linked arabinoxylan in a Ca2+-alginate matrix reversed the body weight gain of HFD-fed C57BL/6J mice through modulation of the gut microbiome.
33571595	2	33	theme	weight	515:520	arg1	gain					522:525	the body weight gain	506:525	the body weight gain induced by the HF diet	506:548	Supplementation of MC in high fat (HF) diet to mice for 10 weeks significantly reversed the body weight gain induced by the HF diet, along with less fat accumulation in both livers and the epididymal adipose than the PM group.
33571595	2	34	theme	HF	453:454	arg1	diet					457:460	high fat (HF) diet	443:460	high fat (HF) diet to mice for 10 weeks	443:481	Supplementation of MC in high fat (HF) diet to mice for 10 weeks significantly reversed the body weight gain induced by the HF diet, along with less fat accumulation in both livers and the epididymal adipose than the PM group.
33571595	1	35	theme	cross-linked	247:258	arg1	arabinoxylan					260:271	cross-linked arabinoxylan	247:271	cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC)	247:308	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	35	theme	cross-linked	247:258	arg1	CAX					274:276	CAX	274:276	CAX	274:276	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	2	36	from	Supplementation	418:432	arg1	diet					457:460	high fat (HF) diet	443:460	high fat (HF) diet to mice for 10 weeks	443:481	Supplementation of MC in high fat (HF) diet to mice for 10 weeks significantly reversed the body weight gain induced by the HF diet, along with less fat accumulation in both livers and the epididymal adipose than the PM group.
33571595	1	37	theme	C57BL/6J	403:410	arg1	mice					412:415	C57BL/6J mice	403:415	C57BL/6J mice	403:415	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	3	38	theme	gut	706:708	arg1	composition					721:731	the gut microbiota composition	702:731	the gut microbiota composition	702:731	Microbiome analysis showed that MC significantly altered the gut microbiota composition with a noticeable increase of butyrogenic bacteria of Lachnospiraceae.
33571595	2	39	theme	epididymal	607:616	arg1	adipose					618:624	the epididymal adipose	603:624	the epididymal adipose than the PM group	603:642	Supplementation of MC in high fat (HF) diet to mice for 10 weeks significantly reversed the body weight gain induced by the HF diet, along with less fat accumulation in both livers and the epididymal adipose than the PM group.
33571595	1	40	theme	arabinoxylan	260:271	arg1	microsphere					232:242	a microsphere	230:242	a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM)	230:353	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	41	from	microsphere	232:242	arg1	MC					306:307	MC	306:307	MC	306:307	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	41	from	microsphere	232:242	arg1	matrix					298:303	a Ca2+-alginate matrix	282:303	a Ca2+-alginate matrix (MC)	282:308	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	42	theme	different	182:190	arg1	forms					201:205	different physical forms	182:205	different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM)	182:353	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	4	43	theme	underlying	905:914	arg1	mechanism					916:924	the underlying mechanism	901:924	the underlying mechanism of the anti-obesity effect of MC	901:957	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	4	43	theme	underlying	905:914	arg1	butyrate					808:815	The butyrate	804:815	The butyrate produced by MC fermentation	804:843	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	4	43	theme	underlying	905:914	arg1	abundance					863:871	the increased abundance	849:871	the increased abundance of Lachnospiraceae	849:890	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	0	44	theme	gut	133:135	arg1	microbiome					137:146	the gut microbiome	129:146	the gut microbiome	129:146	Cross-linked arabinoxylan in a Ca2+-alginate matrix reversed the body weight gain of HFD-fed C57BL/6J mice through modulation of the gut microbiome.
33571595	1	45	theme	AX	334:335	arg1	arabinoxylan					260:271	cross-linked arabinoxylan	247:271	cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC)	247:308	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	45	theme	AX	334:335	arg1	CAX					274:276	CAX	274:276	CAX	274:276	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	45	theme	AX	334:335	arg1	mixture					323:329	physical mixture	314:329	physical mixture of AX and alginate (PM)	314:353	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	46	theme	physical	192:199	arg1	forms					201:205	different physical forms	182:205	different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM)	182:353	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	0	47	theme	Ca2+-alginate	31:43	arg1	matrix					45:50	a Ca2+-alginate matrix	29:50	a Ca2+-alginate matrix	29:50	Cross-linked arabinoxylan in a Ca2+-alginate matrix reversed the body weight gain of HFD-fed C57BL/6J mice through modulation of the gut microbiome.
33571595	4	48	theme	MC	829:830	arg1	fermentation					832:843	MC fermentation	829:843	MC fermentation	829:843	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	2	49	from	adipose	618:624	arg1	livers					592:597	both livers	587:597	both livers	587:597	Supplementation of MC in high fat (HF) diet to mice for 10 weeks significantly reversed the body weight gain induced by the HF diet, along with less fat accumulation in both livers and the epididymal adipose than the PM group.
33571595	1	50	theme	forms	201:205	arg1	effects					171:177	the effects	167:177	the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice	167:415	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	2	51	theme	fat	448:450	arg1	diet					457:460	high fat (HF) diet	443:460	high fat (HF) diet to mice for 10 weeks	443:481	Supplementation of MC in high fat (HF) diet to mice for 10 weeks significantly reversed the body weight gain induced by the HF diet, along with less fat accumulation in both livers and the epididymal adipose than the PM group.
33571595	1	52	theme	alginate	341:348	arg1	arabinoxylan					260:271	cross-linked arabinoxylan	247:271	cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC)	247:308	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	52	theme	alginate	341:348	arg1	CAX					274:276	CAX	274:276	CAX	274:276	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	52	theme	alginate	341:348	arg1	mixture					323:329	physical mixture	314:329	physical mixture of AX and alginate (PM)	314:353	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	5	53	theme	dietary	1009:1015	arg1	fiber					1017:1021	dietary fiber	1009:1021	dietary fiber	1009:1021	The results indicated that the physical forms of dietary fiber are closely associated with its health benefits, and MC might be served as a new functional food ingredient to prevent obesity.
33571595	1	54	from	matrix	298:303	arg1	microsphere					232:242	a microsphere	230:242	a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM)	230:353	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	0	55	theme	microbiome	137:146	arg1	modulation					115:124	modulation	115:124	modulation of the gut microbiome	115:146	Cross-linked arabinoxylan in a Ca2+-alginate matrix reversed the body weight gain of HFD-fed C57BL/6J mice through modulation of the gut microbiome.
33571595	3	56	theme	noticeable	740:749	arg1	increase					751:758	a noticeable increase	738:758	a noticeable increase of butyrogenic bacteria of Lachnospiraceae	738:801	Microbiome analysis showed that MC significantly altered the gut microbiota composition with a noticeable increase of butyrogenic bacteria of Lachnospiraceae.
33571595	3	57	theme	Microbiome	645:654	arg1	analysis					656:663	Microbiome analysis	645:663	Microbiome analysis	645:663	Microbiome analysis showed that MC significantly altered the gut microbiota composition with a noticeable increase of butyrogenic bacteria of Lachnospiraceae.
33571595	5	58	theme	functional	1104:1113	arg1	ingredient					1120:1129	a new functional food ingredient	1098:1129	a new functional food ingredient to prevent obesity	1098:1148	The results indicated that the physical forms of dietary fiber are closely associated with its health benefits, and MC might be served as a new functional food ingredient to prevent obesity.
33571595	4	59	theme	MC	956:957	arg1	effect					946:951	the anti-obesity effect	929:951	the anti-obesity effect of MC	929:957	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	1	60	from	obesity	392:398	arg1	mice					412:415	C57BL/6J mice	403:415	C57BL/6J mice	403:415	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	61	theme	arabinoxylan	210:221	arg1	forms					201:205	different physical forms	182:205	different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM)	182:353	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	0	62	theme	weight	70:75	arg1	gain					77:80	the body weight gain	61:80	the body weight gain of HFD-fed C57BL/6J mice	61:105	Cross-linked arabinoxylan in a Ca2+-alginate matrix reversed the body weight gain of HFD-fed C57BL/6J mice through modulation of the gut microbiome.
33571595	1	63	from	effects	171:177	arg1	development					377:387	development	377:387	development of obesity in C57BL/6J mice	377:415	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	63	from	effects	171:177	arg1	microbiota					362:371	gut microbiota	358:371	gut microbiota	358:371	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	0	64	theme	body	65:68	arg1	gain					77:80	the body weight gain	61:80	the body weight gain of HFD-fed C57BL/6J mice	61:105	Cross-linked arabinoxylan in a Ca2+-alginate matrix reversed the body weight gain of HFD-fed C57BL/6J mice through modulation of the gut microbiome.
33571595	1	65	theme	Ca2+-alginate	284:296	arg1	MC					306:307	MC	306:307	MC	306:307	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	65	theme	Ca2+-alginate	284:296	arg1	matrix					298:303	a Ca2+-alginate matrix	282:303	a Ca2+-alginate matrix (MC)	282:308	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	4	66	theme	effect	946:951	arg1	mechanism					916:924	the underlying mechanism	901:924	the underlying mechanism of the anti-obesity effect of MC	901:957	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	4	66	theme	effect	946:951	arg1	butyrate					808:815	The butyrate	804:815	The butyrate produced by MC fermentation	804:843	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	4	66	theme	effect	946:951	arg1	abundance					863:871	the increased abundance	849:871	the increased abundance of Lachnospiraceae	849:890	The butyrate produced by MC fermentation and the increased abundance of Lachnospiraceae might be the underlying mechanism of the anti-obesity effect of MC.
33571595	1	67	from	mice	412:415	arg1	development					377:387	development	377:387	development of obesity in C57BL/6J mice	377:415	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	67	from	mice	412:415	arg1	microbiota					362:371	gut microbiota	358:371	gut microbiota	358:371	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	1	68	from	development	377:387	arg1	mice					412:415	C57BL/6J mice	403:415	C57BL/6J mice	403:415	Here, we compared the effects of different physical forms of arabinoxylan (AX) - a microsphere of cross-linked arabinoxylan (CAX) in a Ca2+-alginate matrix (MC) and physical mixture of AX and alginate (PM) on gut microbiota and development of obesity in C57BL/6J mice.
33571595	3	69	theme	bacteria	775:782	arg1	increase					751:758	a noticeable increase	738:758	a noticeable increase of butyrogenic bacteria of Lachnospiraceae	738:801	Microbiome analysis showed that MC significantly altered the gut microbiota composition with a noticeable increase of butyrogenic bacteria of Lachnospiraceae.
33571595	2	70	theme	high	443:446	arg1	diet					457:460	high fat (HF) diet	443:460	high fat (HF) diet to mice for 10 weeks	443:481	Supplementation of MC in high fat (HF) diet to mice for 10 weeks significantly reversed the body weight gain induced by the HF diet, along with less fat accumulation in both livers and the epididymal adipose than the PM group.
32919659	5	0	theme	various	1056:1062	arg1	shapes					1072:1077	various complex shapes	1056:1077	various complex shapes	1056:1077	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	1	1	theme	/chitosan-citrate	263:279	arg1	hydrogel					308:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	1	1	theme	/chitosan-citrate	263:279	arg1	hydrogel					219:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	0	2	theme	network	100:106	arg1	hydrogel					108:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel	0:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing	0:141	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor.
32919659	3	3	theme	wide	665:668	arg1	window					677:682	a wide strain window	663:682	a wide strain window	663:682	Furthermore, the resistance of the P(SBMA-co-AAc)/CS-Cit DN hydrogel is sensitive to a wide strain window and the relative resistance shows stable and reliable change during deformation.
32919659	1	4	theme	crosslinked	187:197	arg1	hydrogel					219:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	1	4	theme	crosslinked	187:197	arg1	hydrogel					308:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	0	5	theme	potential	121:129	arg1	printing					134:141	potential 3D printing	121:141	potential 3D printing	121:141	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor.
32919659	1	6	theme	electrostatic	340:352	arg1	interaction					354:364	electrostatic interaction	340:364	electrostatic interaction	340:364	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	5	7	theme	hydrogel	1023:1030	arg1	sensor					1032:1037	the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor	994:1037	the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor	994:1037	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	5	8	theme	ionic	909:913	arg1	crosslinking					915:926	ionic crosslinking	909:926	ionic crosslinking	909:926	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	5	9	theme	citrate	1142:1148	arg1	solution					1150:1157	citrate solution	1142:1157	citrate solution	1142:1157	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	2	10	theme	high	563:566	arg1	efficiency					549:558	a self-healing efficiency	534:558	a self-healing efficiency as high as 95.4%	534:575	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	1	11	theme	double	199:204	arg1	hydrogel					219:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	1	11	theme	double	199:204	arg1	hydrogel					308:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	0	12	theme	3D	131:132	arg1	printing					134:141	potential 3D printing	121:141	potential 3D printing	121:141	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor.
32919659	1	13	theme	hydrogen	370:377	arg1	bonding					379:385	hydrogen bonding	370:385	hydrogen bonding	370:385	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	5	14	theme	composite	1118:1126	arg1	hydrogel					1128:1135	the P(SBMA-co-AAc)/CS-Cit composite hydrogel	1092:1135	the P(SBMA-co-AAc)/CS-Cit composite hydrogel	1092:1135	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	1	15	theme	network	206:212	arg1	hydrogel					219:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	1	15	theme	network	206:212	arg1	hydrogel					308:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	0	16	theme	transparent	7:17	arg1	hydrogel					108:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel	0:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing	0:141	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor.
32919659	3	17	theme	relative	692:699	arg1	resistance					701:710	the relative resistance	688:710	the relative resistance	688:710	Furthermore, the resistance of the P(SBMA-co-AAc)/CS-Cit DN hydrogel is sensitive to a wide strain window and the relative resistance shows stable and reliable change during deformation.
32919659	4	18	theme	human	832:836	arg1	swallowing					873:882	swallowing	873:882	swallowing	873:882	Herein, the hydrogel was demonstrated as a strain sensor to detect human motions, such as joint bending and swallowing.
32919659	4	18	theme	human	832:836	arg1	bending					861:867	joint bending	855:867	joint bending	855:867	Herein, the hydrogel was demonstrated as a strain sensor to detect human motions, such as joint bending and swallowing.
32919659	4	18	theme	human	832:836	arg1	motions					838:844	human motions	832:844	human motions	832:844	Herein, the hydrogel was demonstrated as a strain sensor to detect human motions, such as joint bending and swallowing.
32919659	2	19	theme	self-healing	505:516	arg1	properties					518:527	good self-healing properties	500:527	good self-healing properties	500:527	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	5	20	theme	complex	1064:1070	arg1	shapes					1072:1077	various complex shapes	1056:1077	various complex shapes	1056:1077	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	3	21	theme	reliable	729:736	arg1	change					738:743	stable and reliable change	718:743	stable and reliable change	718:743	Furthermore, the resistance of the P(SBMA-co-AAc)/CS-Cit DN hydrogel is sensitive to a wide strain window and the relative resistance shows stable and reliable change during deformation.
32919659	2	22	dep	stretchable	438:448	arg1	anti-fatigue					464:475	anti-fatigue	464:475	anti-fatigue	464:475	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	2	22	dep	stretchable	438:448	arg1	transparent					451:461	transparent	451:461	transparent	451:461	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	2	22	dep	stretchable	438:448	arg1	hydrogel					419:426	The hydrogel	415:426	The hydrogel	415:426	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	2	22	dep	stretchable	438:448	arg1	stretchable					438:448	stretchable	438:448	stretchable	438:448	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	2	22	dep	stretchable	438:448	arg1	self-adhesive					478:490	self-adhesive	478:490	self-adhesive	478:490	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	1	23	theme	DN	215:216	arg1	hydrogel					219:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	1	23	theme	DN	215:216	arg1	hydrogel					308:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	0	24	theme	self-healing	20:31	arg1	hydrogel					108:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel	0:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing	0:141	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor.
32919659	0	25	theme	strain	152:157	arg1	sensor					159:164	strain sensor	152:164	strain sensor	152:164	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor.
32919659	5	26	theme	3D	1242:1243	arg1	sensors					1261:1267	3D printing strain sensors	1242:1267	3D printing strain sensors	1242:1267	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	4	27	dep	sensor	815:820	arg1	detect					825:830	detect	825:830	to detect human motions, such as joint bending and swallowing	822:882	Herein, the hydrogel was demonstrated as a strain sensor to detect human motions, such as joint bending and swallowing.
32919659	3	28	theme	stable	718:723	arg1	change					738:743	stable and reliable change	718:743	stable and reliable change	718:743	Furthermore, the resistance of the P(SBMA-co-AAc)/CS-Cit DN hydrogel is sensitive to a wide strain window and the relative resistance shows stable and reliable change during deformation.
32919659	1	29	link	crosslinked	187:197	arg1	hydrogel					219:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	1	29	link	crosslinked	187:197	arg1	hydrogel					308:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	3	30	theme	DN	635:636	arg1	hydrogel					638:645	the P(SBMA-co-AAc)/CS-Cit DN hydrogel	609:645	the P(SBMA-co-AAc)/CS-Cit DN hydrogel	609:645	Furthermore, the resistance of the P(SBMA-co-AAc)/CS-Cit DN hydrogel is sensitive to a wide strain window and the relative resistance shows stable and reliable change during deformation.
32919659	5	31	theme	printing	1245:1252	arg1	sensors					1261:1267	3D printing strain sensors	1242:1267	3D printing strain sensors	1242:1267	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	0	32	theme	injectable	34:43	arg1	hydrogel					108:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel	0:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing	0:141	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor.
32919659	5	33	theme	/CS-Cit	1110:1116	arg1	hydrogel					1128:1135	the P(SBMA-co-AAc)/CS-Cit composite hydrogel	1092:1135	the P(SBMA-co-AAc)/CS-Cit composite hydrogel	1092:1135	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	3	34	theme	hydrogel	638:645	arg1	resistance					595:604	the resistance	591:604	the resistance of the P(SBMA-co-AAc)/CS-Cit DN hydrogel	591:645	Furthermore, the resistance of the P(SBMA-co-AAc)/CS-Cit DN hydrogel is sensitive to a wide strain window and the relative resistance shows stable and reliable change during deformation.
32919659	3	34	theme	hydrogel	638:645	arg1	sensitive					650:658	sensitive	650:658	sensitive	650:658	Furthermore, the resistance of the P(SBMA-co-AAc)/CS-Cit DN hydrogel is sensitive to a wide strain window and the relative resistance shows stable and reliable change during deformation.
32919659	5	35	theme	strain	1254:1259	arg1	sensors					1261:1267	3D printing strain sensors	1242:1267	3D printing strain sensors	1242:1267	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	1	36	theme	DN	305:306	arg1	hydrogel					308:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel	229:315	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	1	36	theme	DN	305:306	arg1	hydrogel					219:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel	167:226	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	1	37	theme	polymer	399:405	arg1	chains					407:412	the polymer chains	395:412	the polymer chains	395:412	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	0	38	theme	self-adhesive	49:61	arg1	hydrogel					108:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel	0:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing	0:141	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor.
32919659	2	39	theme	self-healing	536:547	arg1	efficiency					549:558	a self-healing efficiency	534:558	a self-healing efficiency as high as 95.4%	534:575	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	2	40	theme	good	500:503	arg1	properties					518:527	good self-healing properties	500:527	good self-healing properties	500:527	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	4	41	theme	strain	808:813	arg1	hydrogel					777:784	the hydrogel	773:784	the hydrogel	773:784	Herein, the hydrogel was demonstrated as a strain sensor to detect human motions, such as joint bending and swallowing.
32919659	4	41	theme	strain	808:813	arg1	sensor					815:820	a strain sensor	806:820	a strain sensor to detect human motions, such as joint bending and swallowing	806:882	Herein, the hydrogel was demonstrated as a strain sensor to detect human motions, such as joint bending and swallowing.
32919659	2	42	contain	has	496:498	arg1	stretchable					438:448	stretchable	438:448	stretchable	438:448	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	2	42	contain	has	496:498	arg1	transparent					451:461	transparent	451:461	transparent	451:461	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	2	42	contain	has	496:498	arg2	properties					518:527	good self-healing properties	500:527	good self-healing properties	500:527	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	2	42	contain	has	496:498	arg1	hydrogel					419:426	The hydrogel	415:426	The hydrogel	415:426	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	2	42	contain	has	496:498	arg1	anti-fatigue					464:475	anti-fatigue	464:475	anti-fatigue	464:475	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	2	42	contain	has	496:498	arg1	self-adhesive					478:490	self-adhesive	478:490	self-adhesive	478:490	The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%.
32919659	3	43	theme	strain	670:675	arg1	window					677:682	a wide strain window	663:682	a wide strain window	663:682	Furthermore, the resistance of the P(SBMA-co-AAc)/CS-Cit DN hydrogel is sensitive to a wide strain window and the relative resistance shows stable and reliable change during deformation.
32919659	4	44	theme	joint	855:859	arg1	bending					861:867	joint bending	855:867	joint bending	855:867	Herein, the hydrogel was demonstrated as a strain sensor to detect human motions, such as joint bending and swallowing.
32919659	3	45	theme	/CS-Cit	627:633	arg1	hydrogel					638:645	the P(SBMA-co-AAc)/CS-Cit DN hydrogel	609:645	the P(SBMA-co-AAc)/CS-Cit DN hydrogel	609:645	Furthermore, the resistance of the P(SBMA-co-AAc)/CS-Cit DN hydrogel is sensitive to a wide strain window and the relative resistance shows stable and reliable change during deformation.
32919659	5	46	theme	DN	1020:1021	arg1	sensor					1032:1037	the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor	994:1037	the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor	994:1037	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	5	47	theme	great	1206:1210	arg1	potential					1212:1220	a great potential	1204:1220	a great potential for applications as 3D printing strain sensors	1204:1267	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	1	48	dep	/chitosan-citrate	263:279	arg1	/CS-Cit					296:302	/CS-Cit	296:302	/CS-Cit	296:302	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	1	48	dep	/chitosan-citrate	263:279	arg1	acid					258:261	sulfobetaine-co-acrylic acid	234:261	sulfobetaine-co-acrylic acid	234:261	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	5	49	theme	/CS-Cit	947:953	arg1	injectable					977:986	injectable	977:986	injectable	977:986	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	5	49	theme	/CS-Cit	947:953	arg1	hydrogel					965:972	the P(SBMA-co-AAc)/CS-Cit composite hydrogel	929:972	the P(SBMA-co-AAc)/CS-Cit composite hydrogel	929:972	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	5	50	theme	/CS-Cit	1012:1018	arg1	sensor					1032:1037	the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor	994:1037	the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor	994:1037	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	1	51	theme	sulfobetaine-co-acrylic	234:256	arg1	acid					258:261	sulfobetaine-co-acrylic acid	234:261	sulfobetaine-co-acrylic acid	234:261	A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains.
32919659	0	52	theme	double	93:98	arg1	hydrogel					108:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel	0:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing	0:141	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor.
32919659	5	53	theme	composite	955:963	arg1	injectable					977:986	injectable	977:986	injectable	977:986	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	5	53	theme	composite	955:963	arg1	hydrogel					965:972	the P(SBMA-co-AAc)/CS-Cit composite hydrogel	929:972	the P(SBMA-co-AAc)/CS-Cit composite hydrogel	929:972	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
32919659	0	54	theme	chitosan/polyzwitterion-based	63:91	arg1	hydrogel					108:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel	0:115	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing	0:141	Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor.
32919659	5	55	theme	multilayer	1170:1179	arg1	structures					1181:1190	multilayer structures	1170:1190	multilayer structures	1170:1190	More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
34127224	1	0	theme	Self-healing	175:186	arg1	hydrogels					188:196	Self-healing hydrogels	175:196	Self-healing hydrogels with pH-responsiveness	175:219	Self-healing hydrogels with pH-responsiveness could protect loaded drugs from being destroyed till it arrives to the target.
34127224	7	1	theme	self-healing	967:978	arg1	performance					980:990	excellent self-healing performance	957:990	excellent self-healing performance	957:990	The self-healing experiments showed excellent self-healing performance.
34127224	0	2	theme	drug	90:93	arg1	delivery					95:102	drug delivery	90:102	drug delivery	90:102	Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility.
34127224	1	3	with	hydrogels	188:196	arg1	pH-responsiveness					203:219	pH-responsiveness	203:219	pH-responsiveness	203:219	Self-healing hydrogels with pH-responsiveness could protect loaded drugs from being destroyed till it arrives to the target.
34127224	6	4	theme	hydrogels	910:918	arg1	density					899:905	the cross-linking density	881:905	the cross-linking density of hydrogels	881:918	By comparison, it can be seen that the Diels-Alder reaction greatly improved the cross-linking density of hydrogels.
34127224	9	5	theme	loading	1159:1165	arg1	studies					1179:1185	The drug loading and release studies	1150:1185	The drug loading and release studies	1150:1185	The drug loading and release studies presented high loading efficiency and sustained release performance.
34127224	4	6	theme	present	623:629	arg1	study					631:635	the present study	619:635	the present study	619:635	In the present study, we prepared a series of self-healing pectin/chitosan hydrogels via the Diels-Alder reaction.
34127224	0	7	theme	high	109:112	arg1	property					123:130	high swelling property	109:130	high swelling property	109:130	Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility.
34127224	8	8	theme	thermo-responsiveness	1127:1147	arg1	property					1109:1116	well-swelling property	1095:1116	well-swelling property	1095:1116	In different swelling mediums, significant transformation in the swelling ratio was shown, indicating well-swelling property, pH- and thermo-responsiveness.
34127224	9	9	theme	release	1171:1177	arg1	studies					1179:1185	The drug loading and release studies	1150:1185	The drug loading and release studies	1150:1185	The drug loading and release studies presented high loading efficiency and sustained release performance.
34127224	6	10	theme	Diels-Alder	843:853	arg1	reaction					855:862	the Diels-Alder reaction	839:862	the Diels-Alder reaction	839:862	By comparison, it can be seen that the Diels-Alder reaction greatly improved the cross-linking density of hydrogels.
34127224	2	11	theme	pectin-based	304:315	arg1	hydrogel					317:324	The pectin-based hydrogel	300:324	The pectin-based hydrogel	300:324	The pectin-based hydrogel is a candidate due to the health benefit, anti-inflammation, antineoplastic activity, nontoxicity, and biospecific degradation, et al.
34127224	2	11	theme	pectin-based	304:315	arg1	candidate					331:339	a candidate	329:339	a candidate due to the health benefit, anti-inflammation, antineoplastic activity, nontoxicity, and biospecific degradation, et al	329:458	The pectin-based hydrogel is a candidate due to the health benefit, anti-inflammation, antineoplastic activity, nontoxicity, and biospecific degradation, et al.
34127224	7	12	theme	self-healing	925:936	arg1	experiments					938:948	The self-healing experiments	921:948	The self-healing experiments	921:948	The self-healing experiments showed excellent self-healing performance.
34127224	4	13	theme	Diels-Alder	709:719	arg1	reaction					721:728	the Diels-Alder reaction	705:728	the Diels-Alder reaction	705:728	In the present study, we prepared a series of self-healing pectin/chitosan hydrogels via the Diels-Alder reaction.
34127224	0	14	theme	swelling	114:121	arg1	property					123:130	high swelling property	109:130	high swelling property	109:130	Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility.
34127224	8	15	theme	well-swelling	1095:1107	arg1	property					1109:1116	well-swelling property	1095:1116	well-swelling property	1095:1116	In different swelling mediums, significant transformation in the swelling ratio was shown, indicating well-swelling property, pH- and thermo-responsiveness.
34127224	10	16	theme	cell	1298:1301	arg1	ratio					1317:1321	a high cell proliferation ratio	1291:1321	a high cell proliferation ratio	1291:1321	The cytotoxicity assay that showed a high cell proliferation ratio manifested great cytocompatibility.
34127224	9	17	theme	high	1197:1200	arg1	efficiency					1210:1219	high loading efficiency	1197:1219	high loading efficiency	1197:1219	The drug loading and release studies presented high loading efficiency and sustained release performance.
34127224	9	18	theme	drug	1154:1157	arg1	loading					1159:1165	drug loading	1154:1165	drug loading	1154:1165	The drug loading and release studies presented high loading efficiency and sustained release performance.
34127224	2	19	theme	due	341:343	arg1	hydrogel					317:324	The pectin-based hydrogel	300:324	The pectin-based hydrogel	300:324	The pectin-based hydrogel is a candidate due to the health benefit, anti-inflammation, antineoplastic activity, nontoxicity, and biospecific degradation, et al.
34127224	2	19	theme	due	341:343	arg1	candidate					331:339	a candidate	329:339	a candidate due to the health benefit, anti-inflammation, antineoplastic activity, nontoxicity, and biospecific degradation, et al	329:458	The pectin-based hydrogel is a candidate due to the health benefit, anti-inflammation, antineoplastic activity, nontoxicity, and biospecific degradation, et al.
34127224	9	20	theme	loading	1202:1208	arg1	efficiency					1210:1219	high loading efficiency	1197:1219	high loading efficiency	1197:1219	The drug loading and release studies presented high loading efficiency and sustained release performance.
34127224	8	21	theme	pH-	1119:1121	arg1	property					1109:1116	well-swelling property	1095:1116	well-swelling property	1095:1116	In different swelling mediums, significant transformation in the swelling ratio was shown, indicating well-swelling property, pH- and thermo-responsiveness.
34127224	0	22	theme	pectin/chitosan	28:42	arg1	hydrogel					51:58	self-healing pectin/chitosan hybrid hydrogel	15:58	self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery	15:102	Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility.
34127224	3	23	theme	potential	605:613	arg1	limitation					587:596	limitation	587:596	limitation of the potential	587:613	However, the abundant existence of water-soluble branched heteropolysaccharide chains influenced its performance resulting in limitation of the potential.
34127224	1	24	theme	loaded	235:240	arg1	drugs					242:246	loaded drugs	235:246	loaded drugs	235:246	Self-healing hydrogels with pH-responsiveness could protect loaded drugs from being destroyed till it arrives to the target.
34127224	0	25	theme	self-healing	15:26	arg1	hydrogel					51:58	self-healing pectin/chitosan hybrid hydrogel	15:58	self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery	15:102	Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility.
34127224	8	26	theme	different	996:1004	arg1	mediums					1015:1021	different swelling mediums	996:1021	different swelling mediums	996:1021	In different swelling mediums, significant transformation in the swelling ratio was shown, indicating well-swelling property, pH- and thermo-responsiveness.
34127224	4	27	theme	self-healing	662:673	arg1	hydrogels					691:699	self-healing pectin/chitosan hydrogels	662:699	self-healing pectin/chitosan hydrogels	662:699	In the present study, we prepared a series of self-healing pectin/chitosan hydrogels via the Diels-Alder reaction.
34127224	0	28	theme	hydrogel	51:58	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility.	0:173	Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility.
34127224	4	29	theme	hydrogels	691:699	arg1	series					652:657	a series	650:657	a series of self-healing pectin/chitosan hydrogels	650:699	In the present study, we prepared a series of self-healing pectin/chitosan hydrogels via the Diels-Alder reaction.
34127224	9	30	theme	sustained	1225:1233	arg1	performance					1243:1253	sustained release performance	1225:1253	sustained release performance	1225:1253	The drug loading and release studies presented high loading efficiency and sustained release performance.
34127224	0	31	theme	hybrid	44:49	arg1	hydrogel					51:58	self-healing pectin/chitosan hybrid hydrogel	15:58	self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery	15:102	Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility.
34127224	10	32	theme	great	1334:1338	arg1	cytocompatibility					1340:1356	great cytocompatibility	1334:1356	great cytocompatibility	1334:1356	The cytotoxicity assay that showed a high cell proliferation ratio manifested great cytocompatibility.
34127224	9	33	theme	release	1235:1241	arg1	performance					1243:1253	sustained release performance	1225:1253	sustained release performance	1225:1253	The drug loading and release studies presented high loading efficiency and sustained release performance.
34127224	2	34	theme	biospecific	429:439	arg1	degradation					441:451	biospecific degradation	429:451	biospecific degradation	429:451	The pectin-based hydrogel is a candidate due to the health benefit, anti-inflammation, antineoplastic activity, nontoxicity, and biospecific degradation, et al.
34127224	0	35	theme	Diels-Alder	64:74	arg1	reactions					76:84	Diels-Alder reactions	64:84	Diels-Alder reactions	64:84	Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility.
34127224	8	36	from	transformation	1036:1049	arg1	ratio					1067:1071	the swelling ratio	1054:1071	the swelling ratio	1054:1071	In different swelling mediums, significant transformation in the swelling ratio was shown, indicating well-swelling property, pH- and thermo-responsiveness.
34127224	1	37	dep	till	269:272	arg1	it					274:275	it	274:275	it	274:275	Self-healing hydrogels with pH-responsiveness could protect loaded drugs from being destroyed till it arrives to the target.
34127224	8	38	theme	swelling	1006:1013	arg1	mediums					1015:1021	different swelling mediums	996:1021	different swelling mediums	996:1021	In different swelling mediums, significant transformation in the swelling ratio was shown, indicating well-swelling property, pH- and thermo-responsiveness.
34127224	3	39	theme	heteropolysaccharide	519:538	arg1	chains					540:545	water-soluble branched heteropolysaccharide chains	496:545	water-soluble branched heteropolysaccharide chains	496:545	However, the abundant existence of water-soluble branched heteropolysaccharide chains influenced its performance resulting in limitation of the potential.
34127224	8	40	theme	significant	1024:1034	arg1	transformation					1036:1049	significant transformation	1024:1049	significant transformation in the swelling ratio	1024:1071	In different swelling mediums, significant transformation in the swelling ratio was shown, indicating well-swelling property, pH- and thermo-responsiveness.
34127224	3	41	theme	chains	540:545	arg1	existence					483:491	the abundant existence	470:491	the abundant existence of water-soluble branched heteropolysaccharide chains	470:545	However, the abundant existence of water-soluble branched heteropolysaccharide chains influenced its performance resulting in limitation of the potential.
34127224	10	42	theme	cytotoxicity	1260:1271	arg1	assay					1273:1277	The cytotoxicity assay	1256:1277	The cytotoxicity assay that showed a high cell proliferation ratio	1256:1321	The cytotoxicity assay that showed a high cell proliferation ratio manifested great cytocompatibility.
34127224	5	43	theme	pectin/chitosan	741:755	arg1	contrast					794:801	a contrast	792:801	a contrast	792:801	Moreover, pectin/chitosan composite hydrogel was prepared as a contrast.
34127224	5	43	theme	pectin/chitosan	741:755	arg1	hydrogel					767:774	pectin/chitosan composite hydrogel	741:774	pectin/chitosan composite hydrogel	741:774	Moreover, pectin/chitosan composite hydrogel was prepared as a contrast.
34127224	0	44	with	Fabrication	0:10	arg1	pH-responsiveness					133:149	pH-responsiveness	133:149	pH-responsiveness	133:149	Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility.
34127224	0	44	with	Fabrication	0:10	arg1	cytocompatibility					156:172	cytocompatibility	156:172	cytocompatibility	156:172	Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility.
34127224	0	44	with	Fabrication	0:10	arg1	property					123:130	high swelling property	109:130	high swelling property	109:130	Fabrication of self-healing pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug delivery with high swelling property, pH-responsiveness, and cytocompatibility.
34127224	2	45	theme	health	352:357	arg1	benefit					359:365	the health benefit	348:365	the health benefit	348:365	The pectin-based hydrogel is a candidate due to the health benefit, anti-inflammation, antineoplastic activity, nontoxicity, and biospecific degradation, et al.
34127224	10	46	theme	proliferation	1303:1315	arg1	ratio					1317:1321	a high cell proliferation ratio	1291:1321	a high cell proliferation ratio	1291:1321	The cytotoxicity assay that showed a high cell proliferation ratio manifested great cytocompatibility.
34127224	5	47	theme	composite	757:765	arg1	contrast					794:801	a contrast	792:801	a contrast	792:801	Moreover, pectin/chitosan composite hydrogel was prepared as a contrast.
34127224	5	47	theme	composite	757:765	arg1	hydrogel					767:774	pectin/chitosan composite hydrogel	741:774	pectin/chitosan composite hydrogel	741:774	Moreover, pectin/chitosan composite hydrogel was prepared as a contrast.
34127224	6	48	theme	cross-linking	885:897	arg1	density					899:905	the cross-linking density	881:905	the cross-linking density of hydrogels	881:918	By comparison, it can be seen that the Diels-Alder reaction greatly improved the cross-linking density of hydrogels.
34127224	3	49	theme	branched	510:517	arg1	chains					540:545	water-soluble branched heteropolysaccharide chains	496:545	water-soluble branched heteropolysaccharide chains	496:545	However, the abundant existence of water-soluble branched heteropolysaccharide chains influenced its performance resulting in limitation of the potential.
34127224	3	50	theme	water-soluble	496:508	arg1	chains					540:545	water-soluble branched heteropolysaccharide chains	496:545	water-soluble branched heteropolysaccharide chains	496:545	However, the abundant existence of water-soluble branched heteropolysaccharide chains influenced its performance resulting in limitation of the potential.
34127224	3	51	theme	abundant	474:481	arg1	existence					483:491	the abundant existence	470:491	the abundant existence of water-soluble branched heteropolysaccharide chains	470:545	However, the abundant existence of water-soluble branched heteropolysaccharide chains influenced its performance resulting in limitation of the potential.
34127224	4	52	theme	pectin/chitosan	675:689	arg1	hydrogels					691:699	self-healing pectin/chitosan hydrogels	662:699	self-healing pectin/chitosan hydrogels	662:699	In the present study, we prepared a series of self-healing pectin/chitosan hydrogels via the Diels-Alder reaction.
34127224	10	53	theme	high	1293:1296	arg1	ratio					1317:1321	a high cell proliferation ratio	1291:1321	a high cell proliferation ratio	1291:1321	The cytotoxicity assay that showed a high cell proliferation ratio manifested great cytocompatibility.
34127224	8	54	theme	swelling	1058:1065	arg1	ratio					1067:1071	the swelling ratio	1054:1071	the swelling ratio	1054:1071	In different swelling mediums, significant transformation in the swelling ratio was shown, indicating well-swelling property, pH- and thermo-responsiveness.
34127224	2	55	theme	antineoplastic	387:400	arg1	activity					402:409	antineoplastic activity	387:409	antineoplastic activity	387:409	The pectin-based hydrogel is a candidate due to the health benefit, anti-inflammation, antineoplastic activity, nontoxicity, and biospecific degradation, et al.
34127224	7	56	theme	excellent	957:965	arg1	performance					980:990	excellent self-healing performance	957:990	excellent self-healing performance	957:990	The self-healing experiments showed excellent self-healing performance.
34893221	0	0	theme	enhanced	100:107	arg1	differentiation					118:132	enhanced neuronal differentiation	100:132	enhanced neuronal differentiation of neural stem cells	100:153	Silk fibroin nanofibrous scaffolds incorporated with microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells.
34893221	8	1	theme	promising	1124:1132	arg1	approach					1134:1141	a promising approach	1122:1141	a promising approach for neural tissue regeneration	1122:1172	In conclusion, the SF nanofibrous scaffolds in combination with miR-222/CS NPs are a promising approach for neural tissue regeneration.
34893221	8	1	theme	promising	1124:1132	arg1	scaffolds					1073:1081	the SF nanofibrous scaffolds	1054:1081	the SF nanofibrous scaffolds in combination with miR-222/CS NPs	1054:1116	In conclusion, the SF nanofibrous scaffolds in combination with miR-222/CS NPs are a promising approach for neural tissue regeneration.
34893221	8	2	with	combination	1086:1096	arg1	NPs					1114:1116	miR-222/CS NPs	1103:1116	miR-222/CS NPs	1103:1116	In conclusion, the SF nanofibrous scaffolds in combination with miR-222/CS NPs are a promising approach for neural tissue regeneration.
34893221	4	3	theme	miR-222/CS	596:605	arg1	NPs					607:609	the miR-222/CS NPs	592:609	the miR-222/CS NPs	592:609	The encapsulation efficiency of miR-222 in the miR-222/CS NPs was (96.4 ± 0.3) %.
34893221	5	4	theme	electrophoretic	650:664	arg1	assay					666:670	the electrophoretic assay	646:670	the electrophoretic assay	646:670	The results of the electrophoretic assay and cellular uptake assay confirmed that miR-222 was stable in the miR-222/CS NPs and can be effectively delivered into NSCs.
34893221	3	5	theme	loaded	394:399	arg1	nanoparticles					410:422	the microRNA-222 loaded chitosan nanoparticles	377:422	the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs)	377:439	Herein, the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs) were incorporated with silk fibroin (SF) nanofibrous scaffolds to enhance neuronal differentiation of NSCs.
34893221	3	5	theme	loaded	394:399	arg1	NPs					436:438	miR-222/CS NPs	425:438	miR-222/CS NPs	425:438	Herein, the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs) were incorporated with silk fibroin (SF) nanofibrous scaffolds to enhance neuronal differentiation of NSCs.
34893221	2	6	theme	application	356:366	arg1	aspect					341:346	the most challenging aspect	320:346	the most challenging aspect of NSCs application	320:366	How to enhance the neuronal differentiation of NSCs has been the most challenging aspect of NSCs application.
34893221	5	7	from	stable	725:730	arg1	NPs					750:752	the miR-222/CS NPs	735:752	the miR-222/CS NPs	735:752	The results of the electrophoretic assay and cellular uptake assay confirmed that miR-222 was stable in the miR-222/CS NPs and can be effectively delivered into NSCs.
34893221	5	8	theme	assay	666:670	arg1	results					635:641	The results	631:641	The results of the electrophoretic assay and cellular uptake assay	631:696	The results of the electrophoretic assay and cellular uptake assay confirmed that miR-222 was stable in the miR-222/CS NPs and can be effectively delivered into NSCs.
34893221	3	9	theme	chitosan	401:408	arg1	nanoparticles					410:422	the microRNA-222 loaded chitosan nanoparticles	377:422	the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs)	377:439	Herein, the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs) were incorporated with silk fibroin (SF) nanofibrous scaffolds to enhance neuronal differentiation of NSCs.
34893221	3	9	theme	chitosan	401:408	arg1	NPs					436:438	miR-222/CS NPs	425:438	miR-222/CS NPs	425:438	Herein, the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs) were incorporated with silk fibroin (SF) nanofibrous scaffolds to enhance neuronal differentiation of NSCs.
34893221	2	10	theme	NSCs	306:309	arg1	differentiation					287:301	the neuronal differentiation	274:301	the neuronal differentiation of NSCs	274:309	How to enhance the neuronal differentiation of NSCs has been the most challenging aspect of NSCs application.
34893221	0	11	theme	neuronal	109:116	arg1	differentiation					118:132	enhanced neuronal differentiation	100:132	enhanced neuronal differentiation of neural stem cells	100:153	Silk fibroin nanofibrous scaffolds incorporated with microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells.
34893221	8	12	theme	nanofibrous	1061:1071	arg1	approach					1134:1141	a promising approach	1122:1141	a promising approach for neural tissue regeneration	1122:1172	In conclusion, the SF nanofibrous scaffolds in combination with miR-222/CS NPs are a promising approach for neural tissue regeneration.
34893221	8	12	theme	nanofibrous	1061:1071	arg1	scaffolds					1073:1081	the SF nanofibrous scaffolds	1054:1081	the SF nanofibrous scaffolds in combination with miR-222/CS NPs	1054:1116	In conclusion, the SF nanofibrous scaffolds in combination with miR-222/CS NPs are a promising approach for neural tissue regeneration.
34893221	6	13	theme	water	802:806	arg1	angle					816:820	The water contact angle	798:820	The water contact angle	798:820	The water contact angle decreased from (89 ± 3.05)° for the SF scaffolds to (14 ± 1.00)° for the composite scaffolds.
34893221	2	14	theme	challenging	329:339	arg1	aspect					341:346	the most challenging aspect	320:346	the most challenging aspect of NSCs application	320:366	How to enhance the neuronal differentiation of NSCs has been the most challenging aspect of NSCs application.
34893221	0	15	theme	neural	137:142	arg1	cells					149:153	neural stem cells	137:153	neural stem cells	137:153	Silk fibroin nanofibrous scaffolds incorporated with microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells.
34893221	8	16	theme	neural	1147:1152	arg1	regeneration					1161:1172	neural tissue regeneration	1147:1172	neural tissue regeneration	1147:1172	In conclusion, the SF nanofibrous scaffolds in combination with miR-222/CS NPs are a promising approach for neural tissue regeneration.
34893221	7	17	theme	Western	920:926	arg1	blot					928:931	The Western blot	916:931	The Western blot	916:931	The Western blot and RT-PCR results confirmed that the composite scaffolds could enhance neuronal differentiation of NSCs.
34893221	3	18	theme	NSCs	543:546	arg1	differentiation					524:538	neuronal differentiation	515:538	neuronal differentiation of NSCs	515:546	Herein, the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs) were incorporated with silk fibroin (SF) nanofibrous scaffolds to enhance neuronal differentiation of NSCs.
34893221	8	19	from	scaffolds	1073:1081	arg1	combination					1086:1096	combination	1086:1096	combination with miR-222/CS NPs	1086:1116	In conclusion, the SF nanofibrous scaffolds in combination with miR-222/CS NPs are a promising approach for neural tissue regeneration.
34893221	2	20	theme	neuronal	278:285	arg1	differentiation					287:301	the neuronal differentiation	274:301	the neuronal differentiation of NSCs	274:309	How to enhance the neuronal differentiation of NSCs has been the most challenging aspect of NSCs application.
34893221	4	21	theme	96.4 ± 0.3	616:625	arg1	efficiency					567:576	The encapsulation efficiency	549:576	The encapsulation efficiency of miR-222 in the miR-222/CS NPs	549:609	The encapsulation efficiency of miR-222 in the miR-222/CS NPs was (96.4 ± 0.3) %.
34893221	4	21	theme	96.4 ± 0.3	616:625	arg1	%					628:628	%	628:628	%	628:628	The encapsulation efficiency of miR-222 in the miR-222/CS NPs was (96.4 ± 0.3) %.
34893221	1	22	theme	transplantation	181:195	arg1	therapy					197:203	Neural stem cells (NSCs) transplantation therapy	156:203	Neural stem cells (NSCs) transplantation therapy	156:203	Neural stem cells (NSCs) transplantation therapy is a promising method for neural tissue regeneration.
34893221	1	22	theme	transplantation	181:195	arg1	method					220:225	a promising method	208:225	a promising method for neural tissue regeneration	208:256	Neural stem cells (NSCs) transplantation therapy is a promising method for neural tissue regeneration.
34893221	0	23	theme	fibroin	5:11	arg1	scaffolds					25:33	Silk fibroin nanofibrous scaffolds	0:33	Silk fibroin nanofibrous scaffolds	0:33	Silk fibroin nanofibrous scaffolds incorporated with microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells.
34893221	2	24	theme	most	324:327	arg1	aspect					341:346	the most challenging aspect	320:346	the most challenging aspect of NSCs application	320:366	How to enhance the neuronal differentiation of NSCs has been the most challenging aspect of NSCs application.
34893221	0	25	theme	Silk	0:3	arg1	scaffolds					25:33	Silk fibroin nanofibrous scaffolds	0:33	Silk fibroin nanofibrous scaffolds	0:33	Silk fibroin nanofibrous scaffolds incorporated with microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells.
34893221	0	26	theme	cells	149:153	arg1	differentiation					118:132	enhanced neuronal differentiation	100:132	enhanced neuronal differentiation of neural stem cells	100:153	Silk fibroin nanofibrous scaffolds incorporated with microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells.
34893221	0	27	theme	nanofibrous	13:23	arg1	scaffolds					25:33	Silk fibroin nanofibrous scaffolds	0:33	Silk fibroin nanofibrous scaffolds	0:33	Silk fibroin nanofibrous scaffolds incorporated with microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells.
34893221	6	28	theme	composite	895:903	arg1	scaffolds					905:913	the composite scaffolds	891:913	the composite scaffolds	891:913	The water contact angle decreased from (89 ± 3.05)° for the SF scaffolds to (14 ± 1.00)° for the composite scaffolds.
34893221	0	29	theme	stem	144:147	arg1	cells					149:153	neural stem cells	137:153	neural stem cells	137:153	Silk fibroin nanofibrous scaffolds incorporated with microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells.
34893221	3	30	theme	neuronal	515:522	arg1	differentiation					524:538	neuronal differentiation	515:538	neuronal differentiation of NSCs	515:546	Herein, the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs) were incorporated with silk fibroin (SF) nanofibrous scaffolds to enhance neuronal differentiation of NSCs.
34893221	1	31	theme	promising	210:218	arg1	therapy					197:203	Neural stem cells (NSCs) transplantation therapy	156:203	Neural stem cells (NSCs) transplantation therapy	156:203	Neural stem cells (NSCs) transplantation therapy is a promising method for neural tissue regeneration.
34893221	1	31	theme	promising	210:218	arg1	method					220:225	a promising method	208:225	a promising method for neural tissue regeneration	208:256	Neural stem cells (NSCs) transplantation therapy is a promising method for neural tissue regeneration.
34893221	3	32	theme	miR-222/CS	425:434	arg1	nanoparticles					410:422	the microRNA-222 loaded chitosan nanoparticles	377:422	the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs)	377:439	Herein, the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs) were incorporated with silk fibroin (SF) nanofibrous scaffolds to enhance neuronal differentiation of NSCs.
34893221	3	32	theme	miR-222/CS	425:434	arg1	NPs					436:438	miR-222/CS NPs	425:438	miR-222/CS NPs	425:438	Herein, the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs) were incorporated with silk fibroin (SF) nanofibrous scaffolds to enhance neuronal differentiation of NSCs.
34893221	4	33	theme	miR-222	581:587	arg1	efficiency					567:576	The encapsulation efficiency	549:576	The encapsulation efficiency of miR-222 in the miR-222/CS NPs	549:609	The encapsulation efficiency of miR-222 in the miR-222/CS NPs was (96.4 ± 0.3) %.
34893221	4	33	theme	miR-222	581:587	arg1	%					628:628	%	628:628	%	628:628	The encapsulation efficiency of miR-222 in the miR-222/CS NPs was (96.4 ± 0.3) %.
34893221	7	34	theme	NSCs	1033:1036	arg1	differentiation					1014:1028	neuronal differentiation	1005:1028	neuronal differentiation of NSCs	1005:1036	The Western blot and RT-PCR results confirmed that the composite scaffolds could enhance neuronal differentiation of NSCs.
34893221	5	35	from	NPs	750:752	arg1	stable					725:730	stable	725:730	stable	725:730	The results of the electrophoretic assay and cellular uptake assay confirmed that miR-222 was stable in the miR-222/CS NPs and can be effectively delivered into NSCs.
34893221	3	36	theme	silk	464:467	arg1	fibroin					469:475	silk fibroin	464:475	silk fibroin (SF) nanofibrous scaffolds	464:502	Herein, the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs) were incorporated with silk fibroin (SF) nanofibrous scaffolds to enhance neuronal differentiation of NSCs.
34893221	3	36	theme	silk	464:467	arg1	SF					478:479	SF	478:479	SF	478:479	Herein, the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs) were incorporated with silk fibroin (SF) nanofibrous scaffolds to enhance neuronal differentiation of NSCs.
34893221	8	37	theme	SF	1058:1059	arg1	approach					1134:1141	a promising approach	1122:1141	a promising approach for neural tissue regeneration	1122:1172	In conclusion, the SF nanofibrous scaffolds in combination with miR-222/CS NPs are a promising approach for neural tissue regeneration.
34893221	8	37	theme	SF	1058:1059	arg1	scaffolds					1073:1081	the SF nanofibrous scaffolds	1054:1081	the SF nanofibrous scaffolds in combination with miR-222/CS NPs	1054:1116	In conclusion, the SF nanofibrous scaffolds in combination with miR-222/CS NPs are a promising approach for neural tissue regeneration.
34893221	6	38	theme	°	848:848	arg1	scaffolds					861:869	(89 ± 3.05)° for the SF scaffolds	837:869	(89 ± 3.05)° for the SF scaffolds	837:869	The water contact angle decreased from (89 ± 3.05)° for the SF scaffolds to (14 ± 1.00)° for the composite scaffolds.
34893221	3	39	theme	fibroin	469:475	arg1	scaffolds					494:502	silk fibroin (SF) nanofibrous scaffolds	464:502	silk fibroin (SF) nanofibrous scaffolds	464:502	Herein, the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs) were incorporated with silk fibroin (SF) nanofibrous scaffolds to enhance neuronal differentiation of NSCs.
34893221	0	40	theme	loaded	66:71	arg1	nanoparticles					82:94	microRNA-222 loaded chitosan nanoparticles	53:94	microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells	53:153	Silk fibroin nanofibrous scaffolds incorporated with microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells.
34893221	5	41	theme	cellular	676:683	arg1	assay					692:696	cellular uptake assay	676:696	cellular uptake assay	676:696	The results of the electrophoretic assay and cellular uptake assay confirmed that miR-222 was stable in the miR-222/CS NPs and can be effectively delivered into NSCs.
34893221	8	42	theme	miR-222/CS	1103:1112	arg1	NPs					1114:1116	miR-222/CS NPs	1103:1116	miR-222/CS NPs	1103:1116	In conclusion, the SF nanofibrous scaffolds in combination with miR-222/CS NPs are a promising approach for neural tissue regeneration.
34893221	2	43	theme	NSCs	351:354	arg1	application					356:366	NSCs application	351:366	NSCs application	351:366	How to enhance the neuronal differentiation of NSCs has been the most challenging aspect of NSCs application.
34893221	4	44	theme	encapsulation	553:565	arg1	efficiency					567:576	The encapsulation efficiency	549:576	The encapsulation efficiency of miR-222 in the miR-222/CS NPs	549:609	The encapsulation efficiency of miR-222 in the miR-222/CS NPs was (96.4 ± 0.3) %.
34893221	4	44	theme	encapsulation	553:565	arg1	%					628:628	%	628:628	%	628:628	The encapsulation efficiency of miR-222 in the miR-222/CS NPs was (96.4 ± 0.3) %.
34893221	5	45	theme	uptake	685:690	arg1	assay					692:696	cellular uptake assay	676:696	cellular uptake assay	676:696	The results of the electrophoretic assay and cellular uptake assay confirmed that miR-222 was stable in the miR-222/CS NPs and can be effectively delivered into NSCs.
34893221	5	46	theme	assay	692:696	arg1	results					635:641	The results	631:641	The results of the electrophoretic assay and cellular uptake assay	631:696	The results of the electrophoretic assay and cellular uptake assay confirmed that miR-222 was stable in the miR-222/CS NPs and can be effectively delivered into NSCs.
34893221	6	47	theme	contact	808:814	arg1	angle					816:820	The water contact angle	798:820	The water contact angle	798:820	The water contact angle decreased from (89 ± 3.05)° for the SF scaffolds to (14 ± 1.00)° for the composite scaffolds.
34893221	1	48	theme	neural	231:236	arg1	regeneration					245:256	neural tissue regeneration	231:256	neural tissue regeneration	231:256	Neural stem cells (NSCs) transplantation therapy is a promising method for neural tissue regeneration.
34893221	7	49	theme	neuronal	1005:1012	arg1	differentiation					1014:1028	neuronal differentiation	1005:1028	neuronal differentiation of NSCs	1005:1036	The Western blot and RT-PCR results confirmed that the composite scaffolds could enhance neuronal differentiation of NSCs.
34893221	8	50	from	approach	1134:1141	arg1	conclusion					1042:1051	conclusion	1042:1051	conclusion	1042:1051	In conclusion, the SF nanofibrous scaffolds in combination with miR-222/CS NPs are a promising approach for neural tissue regeneration.
34893221	8	51	theme	tissue	1154:1159	arg1	regeneration					1161:1172	neural tissue regeneration	1147:1172	neural tissue regeneration	1147:1172	In conclusion, the SF nanofibrous scaffolds in combination with miR-222/CS NPs are a promising approach for neural tissue regeneration.
34893221	1	52	theme	Neural	156:161	arg1	cells					168:172	Neural stem cells	156:172	Neural stem cells (NSCs) transplantation therapy	156:203	Neural stem cells (NSCs) transplantation therapy is a promising method for neural tissue regeneration.
34893221	1	52	theme	Neural	156:161	arg1	NSCs					175:178	NSCs	175:178	NSCs	175:178	Neural stem cells (NSCs) transplantation therapy is a promising method for neural tissue regeneration.
34893221	7	53	dep	blot	928:931	arg1	results					944:950	results	944:950	results	944:950	The Western blot and RT-PCR results confirmed that the composite scaffolds could enhance neuronal differentiation of NSCs.
34893221	1	54	theme	tissue	238:243	arg1	regeneration					245:256	neural tissue regeneration	231:256	neural tissue regeneration	231:256	Neural stem cells (NSCs) transplantation therapy is a promising method for neural tissue regeneration.
34893221	7	55	theme	composite	971:979	arg1	scaffolds					981:989	the composite scaffolds	967:989	the composite scaffolds	967:989	The Western blot and RT-PCR results confirmed that the composite scaffolds could enhance neuronal differentiation of NSCs.
34893221	1	56	theme	stem	163:166	arg1	cells					168:172	Neural stem cells	156:172	Neural stem cells (NSCs) transplantation therapy	156:203	Neural stem cells (NSCs) transplantation therapy is a promising method for neural tissue regeneration.
34893221	1	56	theme	stem	163:166	arg1	NSCs					175:178	NSCs	175:178	NSCs	175:178	Neural stem cells (NSCs) transplantation therapy is a promising method for neural tissue regeneration.
34893221	3	57	theme	nanofibrous	482:492	arg1	scaffolds					494:502	silk fibroin (SF) nanofibrous scaffolds	464:502	silk fibroin (SF) nanofibrous scaffolds	464:502	Herein, the microRNA-222 loaded chitosan nanoparticles (miR-222/CS NPs) were incorporated with silk fibroin (SF) nanofibrous scaffolds to enhance neuronal differentiation of NSCs.
34893221	0	58	theme	chitosan	73:80	arg1	nanoparticles					82:94	microRNA-222 loaded chitosan nanoparticles	53:94	microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells	53:153	Silk fibroin nanofibrous scaffolds incorporated with microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells.
34893221	4	59	from	efficiency	567:576	arg1	NPs					607:609	the miR-222/CS NPs	592:609	the miR-222/CS NPs	592:609	The encapsulation efficiency of miR-222 in the miR-222/CS NPs was (96.4 ± 0.3) %.
34893221	1	60	theme	cells	168:172	arg1	therapy					197:203	Neural stem cells (NSCs) transplantation therapy	156:203	Neural stem cells (NSCs) transplantation therapy	156:203	Neural stem cells (NSCs) transplantation therapy is a promising method for neural tissue regeneration.
34893221	1	60	theme	cells	168:172	arg1	method					220:225	a promising method	208:225	a promising method for neural tissue regeneration	208:256	Neural stem cells (NSCs) transplantation therapy is a promising method for neural tissue regeneration.
34893221	5	61	theme	miR-222/CS	739:748	arg1	NPs					750:752	the miR-222/CS NPs	735:752	the miR-222/CS NPs	735:752	The results of the electrophoretic assay and cellular uptake assay confirmed that miR-222 was stable in the miR-222/CS NPs and can be effectively delivered into NSCs.
33483070	0	0	theme	poly	94:97	arg1	performance					115:125	poly(vinyl chloride) performance	94:125	poly(vinyl chloride) performance	94:125	Synthesis of zinc hydroxystannate/reduced graphene oxide composites using chitosan to improve poly(vinyl chloride) performance.
33483070	6	1	from	one-fifth	804:812	arg1	ZHS					834:836	ZHS	834:836	ZHS	834:836	By replacing one-fifth of the zinc ions in ZHS by chitosan cations to obtain Sn-4Zn-1CS/rGO, the ZHS-CS/rGO was found to improve PVC composite performance.
33483070	5	2	theme	flame-retardant	628:642	arg1	properties					659:668	The flame-retardant and mechanical properties	624:668	The flame-retardant and mechanical properties of PVC composites	624:686	The flame-retardant and mechanical properties of PVC composites were investigated using the limiting oxygen index (LOI), a cone calorimeter, and mechanical equipment.
33483070	6	3	theme	zinc	821:824	arg1	ions					826:829	the zinc ions	817:829	the zinc ions in ZHS	817:836	By replacing one-fifth of the zinc ions in ZHS by chitosan cations to obtain Sn-4Zn-1CS/rGO, the ZHS-CS/rGO was found to improve PVC composite performance.
33483070	6	4	theme	ions	826:829	arg1	one-fifth					804:812	one-fifth	804:812	one-fifth of the zinc ions in ZHS by chitosan cations	804:856	By replacing one-fifth of the zinc ions in ZHS by chitosan cations to obtain Sn-4Zn-1CS/rGO, the ZHS-CS/rGO was found to improve PVC composite performance.
33483070	1	5	theme	ion	247:249	arg1	strategy					263:270	ion replacement strategy	247:270	ion replacement strategy	247:270	Chitosan-modified zinc hydroxystannate (ZHS-CS) was synthesized using the cations of the biomaterial chitosan (CS) and ion replacement strategy.
33483070	0	6	theme	vinyl	99:103	arg1	poly					94:97	poly	94:97	poly(vinyl chloride) performance	94:125	Synthesis of zinc hydroxystannate/reduced graphene oxide composites using chitosan to improve poly(vinyl chloride) performance.
33483070	0	6	theme	vinyl	99:103	arg1	chloride					105:112	vinyl chloride	99:112	vinyl chloride	99:112	Synthesis of zinc hydroxystannate/reduced graphene oxide composites using chitosan to improve poly(vinyl chloride) performance.
33483070	1	7	theme	replacement	251:261	arg1	strategy					263:270	ion replacement strategy	247:270	ion replacement strategy	247:270	Chitosan-modified zinc hydroxystannate (ZHS-CS) was synthesized using the cations of the biomaterial chitosan (CS) and ion replacement strategy.
33483070	5	8	theme	oxygen	725:730	arg1	index					732:736	the limiting oxygen index	712:736	the limiting oxygen index (LOI)	712:742	The flame-retardant and mechanical properties of PVC composites were investigated using the limiting oxygen index (LOI), a cone calorimeter, and mechanical equipment.
33483070	5	8	theme	oxygen	725:730	arg1	LOI					739:741	LOI	739:741	LOI	739:741	The flame-retardant and mechanical properties of PVC composites were investigated using the limiting oxygen index (LOI), a cone calorimeter, and mechanical equipment.
33483070	5	9	theme	mechanical	648:657	arg1	properties					659:668	The flame-retardant and mechanical properties	624:668	The flame-retardant and mechanical properties of PVC composites	624:686	The flame-retardant and mechanical properties of PVC composites were investigated using the limiting oxygen index (LOI), a cone calorimeter, and mechanical equipment.
33483070	3	10	dep	microscopy	434:443	arg1	images					445:450	images	445:450	images	445:450	Scanning electron microscopy images indicated that ZHS-CS and rGO were evenly dispersed in ZHS-CS/rGO without agglomeration.
33483070	1	11	theme	strategy	263:270	arg1	cations					202:208	the cations	198:208	the cations of the biomaterial chitosan (CS) and ion replacement strategy	198:270	Chitosan-modified zinc hydroxystannate (ZHS-CS) was synthesized using the cations of the biomaterial chitosan (CS) and ion replacement strategy.
33483070	6	12	theme	chitosan	841:848	arg1	cations					850:856	chitosan cations	841:856	chitosan cations	841:856	By replacing one-fifth of the zinc ions in ZHS by chitosan cations to obtain Sn-4Zn-1CS/rGO, the ZHS-CS/rGO was found to improve PVC composite performance.
33483070	5	13	theme	cone	747:750	arg1	calorimeter					752:762	a cone calorimeter	745:762	a cone calorimeter	745:762	The flame-retardant and mechanical properties of PVC composites were investigated using the limiting oxygen index (LOI), a cone calorimeter, and mechanical equipment.
33483070	5	14	theme	mechanical	769:778	arg1	equipment					780:788	mechanical equipment	769:788	mechanical equipment	769:788	The flame-retardant and mechanical properties of PVC composites were investigated using the limiting oxygen index (LOI), a cone calorimeter, and mechanical equipment.
33483070	2	15	theme	oxide	303:307	arg1	ZHS-CS/rGO					339:348	ZHS-CS/rGO	339:348	ZHS-CS/rGO	339:348	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	2	15	theme	oxide	303:307	arg1	retardant					328:336	reduced graphene oxide (rGO) hybrid flame retardant	286:336	reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO)	286:349	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	6	16	from	ZHS	834:836	arg1	one-fifth					804:812	one-fifth	804:812	one-fifth of the zinc ions in ZHS by chitosan cations	804:856	By replacing one-fifth of the zinc ions in ZHS by chitosan cations to obtain Sn-4Zn-1CS/rGO, the ZHS-CS/rGO was found to improve PVC composite performance.
33483070	6	17	theme	composite	924:932	arg1	performance					934:944	PVC composite performance	920:944	PVC composite performance	920:944	By replacing one-fifth of the zinc ions in ZHS by chitosan cations to obtain Sn-4Zn-1CS/rGO, the ZHS-CS/rGO was found to improve PVC composite performance.
33483070	2	18	theme	graphene	294:301	arg1	rGO					310:312	rGO	310:312	rGO	310:312	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	2	18	theme	graphene	294:301	arg1	oxide					303:307	graphene oxide	294:307	reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO)	286:349	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	2	19	theme	vinyl	393:397	arg1	poly					387:390	flexible poly	378:390	flexible poly (vinyl chloride) (PVC)	378:413	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	2	19	theme	vinyl	393:397	arg1	chloride					399:406	vinyl chloride	393:406	vinyl chloride	393:406	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	6	20	theme	PVC	920:922	arg1	performance					934:944	PVC composite performance	920:944	PVC composite performance	920:944	By replacing one-fifth of the zinc ions in ZHS by chitosan cations to obtain Sn-4Zn-1CS/rGO, the ZHS-CS/rGO was found to improve PVC composite performance.
33483070	2	21	theme	reduced	286:292	arg1	ZHS-CS/rGO					339:348	ZHS-CS/rGO	339:348	ZHS-CS/rGO	339:348	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	2	21	theme	reduced	286:292	arg1	retardant					328:336	reduced graphene oxide (rGO) hybrid flame retardant	286:336	reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO)	286:349	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	3	22	theme	Scanning	416:423	arg1	microscopy					434:443	Scanning electron microscopy	416:443	Scanning electron microscopy images	416:450	Scanning electron microscopy images indicated that ZHS-CS and rGO were evenly dispersed in ZHS-CS/rGO without agglomeration.
33483070	0	23	theme	oxide	51:55	arg1	composites					57:66	graphene oxide composites	42:66	graphene oxide composites	42:66	Synthesis of zinc hydroxystannate/reduced graphene oxide composites using chitosan to improve poly(vinyl chloride) performance.
33483070	2	24	theme	flexible	378:385	arg1	poly					387:390	flexible poly	378:390	flexible poly (vinyl chloride) (PVC)	378:413	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	2	24	theme	flexible	378:385	arg1	chloride					399:406	vinyl chloride	393:406	vinyl chloride	393:406	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	2	24	theme	flexible	378:385	arg1	PVC					410:412	PVC	410:412	PVC	410:412	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	0	25	theme	graphene	42:49	arg1	composites					57:66	graphene oxide composites	42:66	graphene oxide composites	42:66	Synthesis of zinc hydroxystannate/reduced graphene oxide composites using chitosan to improve poly(vinyl chloride) performance.
33483070	4	26	dep	transform	549:557	arg1	infrared					559:566	infrared	559:566	transform infrared spectroscopy results	549:587	Fourier transform infrared spectroscopy results showed that rGO was fully reduced.
33483070	7	27	theme	total	974:978	arg1	release					986:992	total smoke release	974:992	total smoke release of PVC/Sn-4Zn-1CS/rGO	974:1014	The total heat release and total smoke release of PVC/Sn-4Zn-1CS/rGO were reduced by 24.2 and 40.0 %, respectively, from those of pure PVC.
33483070	1	28	theme	biomaterial	217:227	arg1	CS					239:240	CS	239:240	CS	239:240	Chitosan-modified zinc hydroxystannate (ZHS-CS) was synthesized using the cations of the biomaterial chitosan (CS) and ion replacement strategy.
33483070	1	28	theme	biomaterial	217:227	arg1	chitosan					229:236	the biomaterial chitosan	213:236	the biomaterial chitosan (CS)	213:241	Chitosan-modified zinc hydroxystannate (ZHS-CS) was synthesized using the cations of the biomaterial chitosan (CS) and ion replacement strategy.
33483070	7	29	theme	pure	1077:1080	arg1	PVC					1082:1084	pure PVC	1077:1084	pure PVC	1077:1084	The total heat release and total smoke release of PVC/Sn-4Zn-1CS/rGO were reduced by 24.2 and 40.0 %, respectively, from those of pure PVC.
33483070	5	30	theme	limiting	716:723	arg1	index					732:736	the limiting oxygen index	712:736	the limiting oxygen index (LOI)	712:742	The flame-retardant and mechanical properties of PVC composites were investigated using the limiting oxygen index (LOI), a cone calorimeter, and mechanical equipment.
33483070	5	30	theme	limiting	716:723	arg1	LOI					739:741	LOI	739:741	LOI	739:741	The flame-retardant and mechanical properties of PVC composites were investigated using the limiting oxygen index (LOI), a cone calorimeter, and mechanical equipment.
33483070	7	31	theme	PVC/Sn-4Zn-1CS/rGO	997:1014	arg1	release					986:992	total smoke release	974:992	total smoke release of PVC/Sn-4Zn-1CS/rGO	974:1014	The total heat release and total smoke release of PVC/Sn-4Zn-1CS/rGO were reduced by 24.2 and 40.0 %, respectively, from those of pure PVC.
33483070	7	31	theme	PVC/Sn-4Zn-1CS/rGO	997:1014	arg1	release					962:968	The total heat release	947:968	The total heat release	947:968	The total heat release and total smoke release of PVC/Sn-4Zn-1CS/rGO were reduced by 24.2 and 40.0 %, respectively, from those of pure PVC.
33483070	4	32	dep	Fourier	541:547	arg1	transform					549:557	transform	549:557	transform infrared spectroscopy results	549:587	Fourier transform infrared spectroscopy results showed that rGO was fully reduced.
33483070	7	33	theme	smoke	980:984	arg1	release					986:992	total smoke release	974:992	total smoke release of PVC/Sn-4Zn-1CS/rGO	974:1014	The total heat release and total smoke release of PVC/Sn-4Zn-1CS/rGO were reduced by 24.2 and 40.0 %, respectively, from those of pure PVC.
33483070	2	34	theme	flame	322:326	arg1	ZHS-CS/rGO					339:348	ZHS-CS/rGO	339:348	ZHS-CS/rGO	339:348	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	2	34	theme	flame	322:326	arg1	retardant					328:336	reduced graphene oxide (rGO) hybrid flame retardant	286:336	reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO)	286:349	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	2	35	from	use	371:373	arg1	poly					387:390	flexible poly	378:390	flexible poly (vinyl chloride) (PVC)	378:413	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	2	35	from	use	371:373	arg1	chloride					399:406	vinyl chloride	393:406	vinyl chloride	393:406	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	2	35	from	use	371:373	arg1	PVC					410:412	PVC	410:412	PVC	410:412	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	2	36	theme	hybrid	315:320	arg1	ZHS-CS/rGO					339:348	ZHS-CS/rGO	339:348	ZHS-CS/rGO	339:348	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	2	36	theme	hybrid	315:320	arg1	retardant					328:336	reduced graphene oxide (rGO) hybrid flame retardant	286:336	reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO)	286:349	A ZHS-CS and reduced graphene oxide (rGO) hybrid flame retardant (ZHS-CS/rGO) was synthesized for use in flexible poly (vinyl chloride) (PVC).
33483070	5	37	theme	PVC	673:675	arg1	composites					677:686	PVC composites	673:686	PVC composites	673:686	The flame-retardant and mechanical properties of PVC composites were investigated using the limiting oxygen index (LOI), a cone calorimeter, and mechanical equipment.
33483070	1	38	theme	Chitosan-modified	128:144	arg1	ZHS-CS					168:173	ZHS-CS	168:173	ZHS-CS	168:173	Chitosan-modified zinc hydroxystannate (ZHS-CS) was synthesized using the cations of the biomaterial chitosan (CS) and ion replacement strategy.
33483070	1	38	theme	Chitosan-modified	128:144	arg1	hydroxystannate					151:165	Chitosan-modified zinc hydroxystannate	128:165	Chitosan-modified zinc hydroxystannate (ZHS-CS)	128:174	Chitosan-modified zinc hydroxystannate (ZHS-CS) was synthesized using the cations of the biomaterial chitosan (CS) and ion replacement strategy.
33483070	1	39	theme	chitosan	229:236	arg1	cations					202:208	the cations	198:208	the cations of the biomaterial chitosan (CS) and ion replacement strategy	198:270	Chitosan-modified zinc hydroxystannate (ZHS-CS) was synthesized using the cations of the biomaterial chitosan (CS) and ion replacement strategy.
33483070	5	40	theme	composites	677:686	arg1	properties					659:668	The flame-retardant and mechanical properties	624:668	The flame-retardant and mechanical properties of PVC composites	624:686	The flame-retardant and mechanical properties of PVC composites were investigated using the limiting oxygen index (LOI), a cone calorimeter, and mechanical equipment.
33483070	7	41	theme	total	951:955	arg1	release					962:968	The total heat release	947:968	The total heat release	947:968	The total heat release and total smoke release of PVC/Sn-4Zn-1CS/rGO were reduced by 24.2 and 40.0 %, respectively, from those of pure PVC.
33483070	1	42	theme	zinc	146:149	arg1	ZHS-CS					168:173	ZHS-CS	168:173	ZHS-CS	168:173	Chitosan-modified zinc hydroxystannate (ZHS-CS) was synthesized using the cations of the biomaterial chitosan (CS) and ion replacement strategy.
33483070	1	42	theme	zinc	146:149	arg1	hydroxystannate					151:165	Chitosan-modified zinc hydroxystannate	128:165	Chitosan-modified zinc hydroxystannate (ZHS-CS)	128:174	Chitosan-modified zinc hydroxystannate (ZHS-CS) was synthesized using the cations of the biomaterial chitosan (CS) and ion replacement strategy.
33483070	3	43	theme	electron	425:432	arg1	microscopy					434:443	Scanning electron microscopy	416:443	Scanning electron microscopy images	416:450	Scanning electron microscopy images indicated that ZHS-CS and rGO were evenly dispersed in ZHS-CS/rGO without agglomeration.
33483070	7	44	theme	heat	957:960	arg1	release					962:968	The total heat release	947:968	The total heat release	947:968	The total heat release and total smoke release of PVC/Sn-4Zn-1CS/rGO were reduced by 24.2 and 40.0 %, respectively, from those of pure PVC.
33483070	4	45	theme	spectroscopy	568:579	arg1	results					581:587	spectroscopy results	568:587	spectroscopy results	568:587	Fourier transform infrared spectroscopy results showed that rGO was fully reduced.
33483070	0	46	theme	zinc	13:16	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of zinc	0:16	Synthesis of zinc hydroxystannate/reduced graphene oxide composites using chitosan to improve poly(vinyl chloride) performance.
33483070	6	47	from	ions	826:829	arg1	ZHS					834:836	ZHS	834:836	ZHS	834:836	By replacing one-fifth of the zinc ions in ZHS by chitosan cations to obtain Sn-4Zn-1CS/rGO, the ZHS-CS/rGO was found to improve PVC composite performance.
32224173	3	0	theme	reported	865:872	arg1	data					874:877	reported data	865:877	reported data	865:877	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	4	1	theme	Listeria	987:994	arg1	monocytogenes					996:1008	Listeria monocytogenes	987:1008	Listeria monocytogenes	987:1008	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
32224173	1	2	theme	based	169:173	arg1	investigations					175:188	design based investigations	162:188	design based investigations	162:188	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	3	3	theme	water	704:708	arg1	SI					729:730	300.5% SI	722:730	300.5% SI	722:730	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	3	3	theme	water	704:708	arg1	absorption					710:719	very good water absorption	694:719	very good water absorption (300.5% SI)	694:731	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	4	4	dep	enhanced	1061:1068	arg1	%					1088:1088	145.5%	1083:1088	145.5%	1083:1088	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
32224173	0	5	from	Optimality	0:9	arg1	dressing					70:77	wound dressing	64:77	wound dressing	64:77	Optimality of poly-vinyl alcohol/starch/glycerol/citric acid in wound dressing applicable composite films.
32224173	2	6	theme	WL	500:501	arg1	%					502:502	WL%	500:502	WL%	500:502	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	2	6	theme	WL	500:501	arg1	loss					494:497	weight loss	487:497	weight loss (WL%) during 27 days	487:518	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	4	7	dep	thereby	1094:1100	arg1	infer					1102:1106	infer	1102:1106	infer upon the potential associated with its application as a viable wound dressing film	1102:1189	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
32224173	4	8	theme	Gram-positive	972:984	arg1	bacteria					1048:1055	both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria	967:1055	both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria	967:1055	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
32224173	3	9	theme	good	699:702	arg1	SI					729:730	300.5% SI	722:730	300.5% SI	722:730	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	3	9	theme	good	699:702	arg1	absorption					710:719	very good water absorption	694:719	very good water absorption (300.5% SI)	694:731	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	1	10	theme	citric	340:345	arg1	starch					280:285	starch	280:285	starch	280:285	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	1	10	theme	citric	340:345	arg1	acid					347:350	citric acid	340:350	citric acid (CA, 15-40 wt%)	340:366	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	2	11	theme	tensile	521:527	arg1	TS					539:540	TS	539:540	TS	539:540	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	2	11	theme	tensile	521:527	arg1	strength					529:536	tensile strength	521:536	tensile strength (TS)	521:541	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	2	12	theme	strength	529:536	arg1	combinations					446:457	Appropriate combinations	434:457	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E)	434:572	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	4	13	theme	antibacterial	931:943	arg1	effectiveness					945:957	amplified antibacterial effectiveness	921:957	amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria	921:1055	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
32224173	2	14	theme	Appropriate	434:444	arg1	combinations					446:457	Appropriate combinations	434:457	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E)	434:572	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	1	15	dep	alcohol	314:320	arg1	%					336:336	5-10 w/w%	328:336	5-10 w/w%	328:336	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	1	15	dep	alcohol	314:320	arg1	PVA					323:325	PVA	323:325	PVA	323:325	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	3	16	theme	87.5	750:753	arg1	%					754:754	%	754:754	%	754:754	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	2	17	theme	elongation	558:567	arg1	combinations					446:457	Appropriate combinations	434:457	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E)	434:572	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	3	18	theme	%	754:754	arg1	E					755:755	87.5%E	750:755	87.5%E	750:755	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	3	18	theme	%	754:754	arg1	flexibility					737:747	flexibility	737:747	flexibility (87.5%E)	737:756	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	4	19	dep	bacteria	1048:1055	arg1	coli					1042:1045	Escherichia coli	1030:1045	Escherichia coli	1030:1045	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
32224173	2	20	theme	percentage	547:556	arg1	elongation					558:567	percentage elongation	547:567	percentage elongation (%E)	547:572	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	2	20	theme	percentage	547:556	arg1	E					571:571	%E	570:571	%E	570:571	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	0	21	theme	alcohol/starch/glycerol/citric	25:54	arg1	acid					56:59	poly-vinyl alcohol/starch/glycerol/citric acid	14:59	poly-vinyl alcohol/starch/glycerol/citric acid	14:59	Optimality of poly-vinyl alcohol/starch/glycerol/citric acid in wound dressing applicable composite films.
32224173	3	22	theme	optimized	620:628	arg1	composition					630:640	The optimized composition	616:640	The optimized composition	616:640	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	4	23	theme	cell	1070:1073	arg1	growth					1075:1080	cell growth	1070:1080	cell growth	1070:1080	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
32224173	3	24	theme	in-vitro	774:781	arg1	degradation					783:793	in-vitro degradation	774:793	in-vitro degradation (51.4% WL)	774:804	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	3	24	theme	in-vitro	774:781	arg1	%					800:800	51.4% WL	796:803	51.4% WL	796:803	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	1	25	theme	quaternary	214:223	arg1	formulations					225:236	quaternary formulations	214:236	quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films	214:431	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	1	25	theme	quaternary	214:223	arg1	Gl					382:383	Gl	382:383	Gl	382:383	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	0	26	theme	poly-vinyl	14:23	arg1	acid					56:59	poly-vinyl alcohol/starch/glycerol/citric acid	14:59	poly-vinyl alcohol/starch/glycerol/citric acid	14:59	Optimality of poly-vinyl alcohol/starch/glycerol/citric acid in wound dressing applicable composite films.
32224173	4	27	dep	Gram-positive	972:984	arg1	monocytogenes					996:1008	Listeria monocytogenes	987:1008	Listeria monocytogenes	987:1008	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
32224173	1	28	dep	starch	280:285	arg1	%					300:300	5-10 w/w%	292:300	5-10 w/w%	292:300	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	1	28	dep	starch	280:285	arg1	St					288:289	St	288:289	St	288:289	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	1	29	theme	response	127:134	arg1	RSM					157:159	RSM	157:159	RSM	157:159	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	1	29	theme	response	127:134	arg1	methodology					144:154	response surface methodology	127:154	response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films	127:431	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	4	30	theme	amplified	921:929	arg1	effectiveness					945:957	amplified antibacterial effectiveness	921:957	amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria	921:1055	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
32224173	1	31	theme	formulations	225:236	arg1	optimality					200:209	optimality	200:209	optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films	200:431	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	1	32	theme	polyvinyl	304:312	arg1	starch					280:285	starch	280:285	starch	280:285	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	1	32	theme	polyvinyl	304:312	arg1	alcohol					314:320	polyvinyl alcohol	304:320	polyvinyl alcohol (PVA, 5-10 w/w%)	304:337	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	2	33	theme	index	475:479	arg1	combinations					446:457	Appropriate combinations	434:457	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E)	434:572	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	1	34	theme	[variant	238:245	arg1	concentrations					262:275	[variant macromolecular concentrations	238:275	quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films	214:431	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	0	35	theme	acid	56:59	arg1	Optimality					0:9	Optimality	0:9	Optimality of poly-vinyl alcohol/starch/glycerol/citric acid in wound dressing	0:77	Optimality of poly-vinyl alcohol/starch/glycerol/citric acid in wound dressing applicable composite films.
32224173	1	36	dep	acid	347:350	arg1	CA					353:354	CA	353:354	CA	353:354	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	1	36	dep	acid	347:350	arg1	%					365:365	15-40 wt%	357:365	15-40 wt%	357:365	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	2	37	theme	swelling	466:473	arg1	SI					482:483	SI	482:483	SI	482:483	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	2	37	theme	swelling	466:473	arg1	index					475:479	the swelling index	462:479	the swelling index (SI)	462:484	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	3	38	theme	RSM	663:665	arg1	optimization					667:678	RSM optimization	663:678	RSM optimization	663:678	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	1	39	theme	wound	412:416	arg1	films					427:431	wound dressing films	412:431	wound dressing films	412:431	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	1	40	theme	macromolecular	247:260	arg1	concentrations					262:275	[variant macromolecular concentrations	238:275	quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films	214:431	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	4	41	theme	wound	1171:1175	arg1	film					1186:1189	a viable wound dressing film	1162:1189	a viable wound dressing film	1162:1189	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
32224173	2	42	theme	loss	494:497	arg1	combinations					446:457	Appropriate combinations	434:457	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E)	434:572	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	1	43	theme	dressing	418:425	arg1	films					427:431	wound dressing films	412:431	wound dressing films	412:431	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	1	44	theme	surface	136:142	arg1	RSM					157:159	RSM	157:159	RSM	157:159	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	1	44	theme	surface	136:142	arg1	methodology					144:154	response surface methodology	127:154	response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films	127:431	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	0	45	theme	wound	64:68	arg1	dressing					70:77	wound dressing	64:77	wound dressing	64:77	Optimality of poly-vinyl alcohol/starch/glycerol/citric acid in wound dressing applicable composite films.
32224173	2	46	theme	weight	487:492	arg1	%					502:502	WL%	500:502	WL%	500:502	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	2	46	theme	weight	487:492	arg1	loss					494:497	weight loss	487:497	weight loss (WL%) during 27 days	487:518	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	3	47	theme	%	727:727	arg1	SI					729:730	300.5% SI	722:730	300.5% SI	722:730	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	3	47	theme	%	727:727	arg1	absorption					710:719	very good water absorption	694:719	very good water absorption (300.5% SI)	694:731	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	4	48	theme	dressing	1177:1184	arg1	film					1186:1189	a viable wound dressing film	1162:1189	a viable wound dressing film	1162:1189	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
32224173	2	49	theme	%	570:570	arg1	elongation					558:567	percentage elongation	547:567	percentage elongation (%E)	547:572	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	2	49	theme	%	570:570	arg1	E					571:571	%E	570:571	%E	570:571	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	4	50	theme	Gram-negative	1015:1027	arg1	bacteria					1048:1055	both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria	967:1055	both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria	967:1055	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
32224173	2	51	theme	such	602:605	arg1	studies					607:613	such studies	602:613	such studies	602:613	Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies.
32224173	4	52	theme	film	893:896	arg1	constitution					898:909	the film constitution	889:909	the film constitution	889:909	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
32224173	1	53	dep	Gl	382:383	arg1	%					394:394	15-40 wt%	386:394	15-40 wt%	386:394	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	0	54	theme	composite	90:98	arg1	films					100:104	composite films	90:104	composite films	90:104	Optimality of poly-vinyl alcohol/starch/glycerol/citric acid in wound dressing applicable composite films.
32224173	3	55	theme	TS	810:811	arg1	values					821:826	TS (5 MPa) values	810:826	TS (5 MPa) values	810:826	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	3	56	theme	300.5	722:726	arg1	%					727:727	%	727:727	%	727:727	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	1	57	theme	starch	280:285	arg1	concentrations					262:275	[variant macromolecular concentrations	238:275	quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films	214:431	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	1	58	dep	formulations	225:236	arg1	concentrations					262:275	[variant macromolecular concentrations	238:275	quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films	214:431	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	3	59	theme	WL	802:803	arg1	degradation					783:793	in-vitro degradation	774:793	in-vitro degradation (51.4% WL)	774:804	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	3	59	theme	WL	802:803	arg1	%					800:800	51.4% WL	796:803	51.4% WL	796:803	The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data.
32224173	1	60	theme	design	162:167	arg1	investigations					175:188	design based investigations	162:188	design based investigations	162:188	This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5-10 w/w%), polyvinyl alcohol (PVA, 5-10 w/w%), citric acid (CA, 15-40 wt%) and glycerol (Gl, 15-40 wt%)] associated to wound dressing films.
32224173	4	61	theme	viable	1164:1169	arg1	film					1186:1189	a viable wound dressing film	1162:1189	a viable wound dressing film	1162:1189	Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film.
34742827	3	0	theme	harsh	742:746	arg1	acids					748:752	the stomach's harsh acids	728:752	the stomach's harsh acids	728:752	However, the administration of therapeutics through the oral route to target gastrointestinal infections poses challenges to dosage formulation because these active ingredients, particularly relatively fragile biological entities, require protection from the stomach's harsh acids.
34742827	9	1	theme	Eudragit-trehalose	1994:2011	arg1	formulations					2013:2024	Eudragit-trehalose formulations	1994:2024	Eudragit-trehalose formulations	1994:2024	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	1	2	theme	Enteric	95:101	arg1	infections					103:112	Enteric infections	95:112	Enteric infections	95:112	Enteric infections have long constituted a silent epidemic responsible for hundreds of thousands of deaths around the world every year.
34742827	6	3	theme	different	1350:1358	arg1	ratios					1360:1365	different ratios	1350:1365	different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm	1350:1493	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	3	4	theme	oral	529:532	arg1	route					534:538	the oral route	525:538	the oral route	525:538	However, the administration of therapeutics through the oral route to target gastrointestinal infections poses challenges to dosage formulation because these active ingredients, particularly relatively fragile biological entities, require protection from the stomach's harsh acids.
34742827	7	5	theme	Promising	1496:1504	arg1	formulations					1525:1536	Promising Eudragit-trehalose formulations	1496:1536	Promising Eudragit-trehalose formulations	1496:1536	Promising Eudragit-trehalose formulations were subsequently spray-dried and their survival in acidic and alkaline environments studied using a new shadowgraphic imaging method.
34742827	6	6	theme	different	1326:1334	arg1	ratios					1336:1341	different ratios	1326:1341	different ratios	1326:1341	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	2	7	theme	new	319:321	arg1	antibiotics					338:348	new small-molecule antibiotics	319:348	new small-molecule antibiotics	319:348	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	7	8	from	survival	1578:1585	arg1	acidic					1590:1595	acidic	1590:1595	acidic	1590:1595	Promising Eudragit-trehalose formulations were subsequently spray-dried and their survival in acidic and alkaline environments studied using a new shadowgraphic imaging method.
34742827	7	8	from	survival	1578:1585	arg1	environments					1610:1621	alkaline environments	1601:1621	alkaline environments	1601:1621	Promising Eudragit-trehalose formulations were subsequently spray-dried and their survival in acidic and alkaline environments studied using a new shadowgraphic imaging method.
34742827	6	9	theme	chain	1209:1213	arg1	technique					1215:1223	a monodisperse droplet chain technique	1186:1223	a monodisperse droplet chain technique	1186:1223	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	9	10	theme	drugs	2050:2054	arg1	delivery					2038:2045	enteric delivery	2030:2045	enteric delivery of drugs	2030:2054	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	6	11	theme	particles	1419:1427	arg1	formation					1406:1414	formation	1406:1414	formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm	1406:1493	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	3	12	theme	dosage	598:603	arg1	formulation					605:615	dosage formulation	598:615	dosage formulation	598:615	However, the administration of therapeutics through the oral route to target gastrointestinal infections poses challenges to dosage formulation because these active ingredients, particularly relatively fragile biological entities, require protection from the stomach's harsh acids.
34742827	3	13	from	acids	748:752	arg1	protection					712:721	protection	712:721	protection from the stomach's harsh acids	712:752	However, the administration of therapeutics through the oral route to target gastrointestinal infections poses challenges to dosage formulation because these active ingredients, particularly relatively fragile biological entities, require protection from the stomach's harsh acids.
34742827	5	14	theme	active	1137:1142	arg1	component					1144:1152	a possible active component	1126:1152	a possible active component	1126:1152	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	9	15	theme	trehalose	1846:1854	arg1	cores					1856:1860	The trehalose cores	1842:1860	The trehalose cores of particles with higher than 5% w/w of Eudragit	1842:1909	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	6	16	theme	composite	1298:1306	arg1	microparticles					1308:1321	Eudragit-trehalose composite microparticles	1279:1321	Eudragit-trehalose composite microparticles	1279:1321	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	3	17	theme	active	631:636	arg1	ingredients					638:648	these active ingredients	625:648	these active ingredients	625:648	However, the administration of therapeutics through the oral route to target gastrointestinal infections poses challenges to dosage formulation because these active ingredients, particularly relatively fragile biological entities, require protection from the stomach's harsh acids.
34742827	3	17	theme	active	631:636	arg1	entities					694:701	relatively fragile biological entities	664:701	particularly relatively fragile biological entities	651:701	However, the administration of therapeutics through the oral route to target gastrointestinal infections poses challenges to dosage formulation because these active ingredients, particularly relatively fragile biological entities, require protection from the stomach's harsh acids.
34742827	2	18	theme	antibiotic-resistant	261:280	arg1	bacteria					282:289	antibiotic-resistant bacteria	261:289	antibiotic-resistant bacteria	261:289	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	6	19	theme	solvent	1384:1390	arg1	ratios					1360:1365	different ratios	1350:1365	different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm	1350:1493	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	3	20	theme	biological	683:692	arg1	ingredients					638:648	these active ingredients	625:648	these active ingredients	625:648	However, the administration of therapeutics through the oral route to target gastrointestinal infections poses challenges to dosage formulation because these active ingredients, particularly relatively fragile biological entities, require protection from the stomach's harsh acids.
34742827	3	20	theme	biological	683:692	arg1	entities					694:701	relatively fragile biological entities	664:701	particularly relatively fragile biological entities	651:701	However, the administration of therapeutics through the oral route to target gastrointestinal infections poses challenges to dosage formulation because these active ingredients, particularly relatively fragile biological entities, require protection from the stomach's harsh acids.
34742827	6	21	theme	formation	1258:1266	arg1	process					1268:1274	the formation process	1254:1274	the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm	1254:1493	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	0	22	theme	enteric	72:78	arg1	delivery					85:92	enteric drug delivery	72:92	enteric drug delivery	72:92	On the feasibility of spray-dried eudragit-trehalose microparticles for enteric drug delivery.
34742827	2	23	theme	global	246:251	arg1	rise					253:256	the global rise	242:256	the global rise in antibiotic-resistant bacteria	242:289	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	5	24	theme	powder	947:952	arg1	vehicle					954:960	a spray-dried powder vehicle	933:960	a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions	933:1024	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	5	25	theme	capable	962:968	arg1	vehicle					954:960	a spray-dried powder vehicle	933:960	a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions	933:1024	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	6	26	from	process	1268:1274	arg1	ratios					1360:1365	different ratios	1350:1365	different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm	1350:1493	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	4	27	theme	pH	845:846	arg1	conditions					848:857	low pH conditions	841:857	low pH conditions	841:857	Encapsulation of the therapeutics within a pH-responsive coating capable of surviving low pH conditions has the potential to provide such protection.
34742827	2	28	theme	sought-after	413:424	arg1	option					426:431	a much sought-after option	406:431	a much sought-after option in the treatment of enteric infections	406:470	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	6	29	theme	Eudragit	1434:1441	arg1	shells					1443:1448	Eudragit shells	1434:1448	Eudragit shells varying in thickness from 0.13 μm to 0.75 μm	1434:1493	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	4	30	theme	pH-responsive	798:810	arg1	coating					812:818	a pH-responsive coating	796:818	a pH-responsive coating capable of surviving low pH conditions	796:857	Encapsulation of the therapeutics within a pH-responsive coating capable of surviving low pH conditions has the potential to provide such protection.
34742827	2	31	from	rise	253:256	arg1	bacteria					282:289	antibiotic-resistant bacteria	261:289	antibiotic-resistant bacteria	261:289	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	2	32	theme	enteric	453:459	arg1	infections					461:470	enteric infections	453:470	enteric infections	453:470	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	4	33	theme	capable	820:826	arg1	coating					812:818	a pH-responsive coating	796:818	a pH-responsive coating capable of surviving low pH conditions	796:857	Encapsulation of the therapeutics within a pH-responsive coating capable of surviving low pH conditions has the potential to provide such protection.
34742827	6	34	dep	0.75 μm	1487:1493	arg1	to					1484:1485	to	1484:1485	to	1484:1485	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	0	35	theme	spray-dried	22:32	arg1	eudragit-trehalose					34:51	spray-dried eudragit-trehalose	22:51	spray-dried eudragit-trehalose	22:51	On the feasibility of spray-dried eudragit-trehalose microparticles for enteric drug delivery.
34742827	7	36	theme	shadowgraphic	1643:1655	arg1	method					1665:1670	a new shadowgraphic imaging method	1637:1670	a new shadowgraphic imaging method	1637:1670	Promising Eudragit-trehalose formulations were subsequently spray-dried and their survival in acidic and alkaline environments studied using a new shadowgraphic imaging method.
34742827	9	37	theme	exposure	1948:1955	arg1	hour					1940:1943	one hour	1936:1943	one hour of exposure at pH 2	1936:1963	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	7	38	theme	alkaline	1601:1608	arg1	environments					1610:1621	alkaline environments	1601:1621	alkaline environments	1601:1621	Promising Eudragit-trehalose formulations were subsequently spray-dried and their survival in acidic and alkaline environments studied using a new shadowgraphic imaging method.
34742827	5	39	theme	particle	1064:1071	arg1	coating					1073:1079	a protective particle coating	1051:1079	a protective particle coating	1051:1079	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	5	39	theme	particle	1064:1071	arg1	S100					1043:1046	Eudragit® S100	1033:1046	Eudragit® S100	1033:1046	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	6	40	theme	particle	1157:1164	arg1	model					1176:1180	A particle formation model	1155:1180	A particle formation model	1155:1180	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	8	41	theme	protective	1738:1747	arg1	shell					1749:1753	a protective shell	1736:1753	a protective shell in the particles irrespective of the type of solvent used to prepare the formulations	1736:1839	The results demonstrated that Eudragit was capable of creating a protective shell in the particles irrespective of the type of solvent used to prepare the formulations.
34742827	6	42	theme	water-ethanol	1370:1382	arg1	solvent					1384:1390	water-ethanol solvent	1370:1390	water-ethanol solvent	1370:1390	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	2	43	theme	bacteriophage	372:384	arg1	therapy					386:392	bacteriophage therapy	372:392	bacteriophage therapy	372:392	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	8	44	theme	solvent	1800:1806	arg1	type					1792:1795	the type	1788:1795	the type of solvent	1788:1806	The results demonstrated that Eudragit was capable of creating a protective shell in the particles irrespective of the type of solvent used to prepare the formulations.
34742827	6	45	from	ratios	1336:1341	arg1	process					1268:1274	the formation process	1254:1274	the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm	1254:1493	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	9	46	from	hour	1940:1943	arg1	pH					1960:1961	pH 2	1960:1963	pH 2	1960:1963	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	2	47	theme	slow	299:302	arg1	development					304:314	the slow development	295:314	the slow development of new small-molecule antibiotics	295:348	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	9	48	theme	formulations	2013:2024	arg1	potential					1981:1989	the potential	1977:1989	the potential of Eudragit-trehalose formulations for enteric delivery of drugs	1977:2054	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	3	49	theme	gastrointestinal	550:565	arg1	infections					567:576	target gastrointestinal infections	543:576	target gastrointestinal infections	543:576	However, the administration of therapeutics through the oral route to target gastrointestinal infections poses challenges to dosage formulation because these active ingredients, particularly relatively fragile biological entities, require protection from the stomach's harsh acids.
34742827	1	50	theme	thousands	182:190	arg1	hundreds					170:177	hundreds	170:177	hundreds of thousands of deaths around the world every year	170:228	Enteric infections have long constituted a silent epidemic responsible for hundreds of thousands of deaths around the world every year.
34742827	9	51	theme	enteric	2030:2036	arg1	delivery					2038:2045	enteric delivery	2030:2045	enteric delivery of drugs	2030:2054	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	2	52	theme	small-molecule	323:336	arg1	antibiotics					338:348	new small-molecule antibiotics	319:348	new small-molecule antibiotics	319:348	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	6	53	with	particles	1419:1427	arg1	shells					1443:1448	Eudragit shells	1434:1448	Eudragit shells varying in thickness from 0.13 μm to 0.75 μm	1434:1493	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	1	54	theme	deaths	195:200	arg1	thousands					182:190	thousands	182:190	thousands of deaths around the world every year	182:228	Enteric infections have long constituted a silent epidemic responsible for hundreds of thousands of deaths around the world every year.
34742827	7	55	theme	Eudragit-trehalose	1506:1523	arg1	formulations					1525:1536	Promising Eudragit-trehalose formulations	1496:1536	Promising Eudragit-trehalose formulations	1496:1536	Promising Eudragit-trehalose formulations were subsequently spray-dried and their survival in acidic and alkaline environments studied using a new shadowgraphic imaging method.
34742827	8	56	from	shell	1749:1753	arg1	particles					1762:1770	the particles	1758:1770	the particles irrespective of the type of solvent used to prepare the formulations	1758:1839	The results demonstrated that Eudragit was capable of creating a protective shell in the particles irrespective of the type of solvent used to prepare the formulations.
34742827	6	57	used	used	1240:1243	arg2	model					1176:1180	A particle formation model	1155:1180	A particle formation model	1155:1180	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	6	57	used	used	1240:1243	arg2	technique					1215:1223	a monodisperse droplet chain technique	1186:1223	a monodisperse droplet chain technique	1186:1223	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	6	58	theme	droplet	1201:1207	arg1	technique					1215:1223	a monodisperse droplet chain technique	1186:1223	a monodisperse droplet chain technique	1186:1223	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	5	59	theme	possible	1128:1135	arg1	component					1144:1152	a possible active component	1126:1152	a possible active component	1126:1152	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	6	60	theme	microparticles	1308:1321	arg1	process					1268:1274	the formation process	1254:1274	the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm	1254:1493	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	6	61	theme	Eudragit-trehalose	1279:1296	arg1	microparticles					1308:1321	Eudragit-trehalose composite microparticles	1279:1321	Eudragit-trehalose composite microparticles	1279:1321	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	9	62	dep	%	1893:1893	arg1	w/w					1895:1897	w/w	1895:1897	higher than 5% w/w of Eudragit	1880:1909	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	5	63	theme	stabilizing	1100:1110	arg1	excipient					1112:1120	a stabilizing excipient	1098:1120	a stabilizing excipient for a possible active component	1098:1152	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	5	63	theme	stabilizing	1100:1110	arg1	S100					1043:1046	Eudragit® S100	1033:1046	Eudragit® S100	1033:1046	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	3	64	theme	fragile	675:681	arg1	ingredients					638:648	these active ingredients	625:648	these active ingredients	625:648	However, the administration of therapeutics through the oral route to target gastrointestinal infections poses challenges to dosage formulation because these active ingredients, particularly relatively fragile biological entities, require protection from the stomach's harsh acids.
34742827	3	64	theme	fragile	675:681	arg1	entities					694:701	relatively fragile biological entities	664:701	particularly relatively fragile biological entities	651:701	However, the administration of therapeutics through the oral route to target gastrointestinal infections poses challenges to dosage formulation because these active ingredients, particularly relatively fragile biological entities, require protection from the stomach's harsh acids.
34742827	5	65	theme	low	986:988	arg1	pH					990:991	low pH	986:991	low pH comparable to stomach conditions	986:1024	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	9	66	from	pH	1960:1961	arg1	exposure					1948:1955	exposure	1948:1955	exposure at pH 2	1948:1963	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	9	66	from	pH	1960:1961	arg1	hour					1940:1943	one hour	1936:1943	one hour of exposure at pH 2	1936:1963	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	9	67	theme	particles	1865:1873	arg1	cores					1856:1860	The trehalose cores	1842:1860	The trehalose cores of particles with higher than 5% w/w of Eudragit	1842:1909	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	4	68	theme	therapeutics	776:787	arg1	Encapsulation					755:767	Encapsulation	755:767	Encapsulation of the therapeutics within a pH-responsive coating capable of surviving low pH conditions	755:857	Encapsulation of the therapeutics within a pH-responsive coating capable of surviving low pH conditions has the potential to provide such protection.
34742827	0	69	theme	drug	80:83	arg1	delivery					85:92	enteric drug delivery	72:92	enteric drug delivery	72:92	On the feasibility of spray-dried eudragit-trehalose microparticles for enteric drug delivery.
34742827	5	70	theme	spray-dried	935:945	arg1	vehicle					954:960	a spray-dried powder vehicle	933:960	a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions	933:1024	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	4	71	contain	has	859:861	arg1	Encapsulation					755:767	Encapsulation	755:767	Encapsulation of the therapeutics within a pH-responsive coating capable of surviving low pH conditions	755:857	Encapsulation of the therapeutics within a pH-responsive coating capable of surviving low pH conditions has the potential to provide such protection.
34742827	4	71	contain	has	859:861	arg2	potential					867:875	the potential to provide such protection	863:902	the potential to provide such protection	863:902	Encapsulation of the therapeutics within a pH-responsive coating capable of surviving low pH conditions has the potential to provide such protection.
34742827	2	72	from	development	304:314	arg1	bacteria					282:289	antibiotic-resistant bacteria	261:289	antibiotic-resistant bacteria	261:289	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	2	73	theme	antibiotics	338:348	arg1	rise					253:256	the global rise	242:256	the global rise in antibiotic-resistant bacteria	242:289	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	2	73	theme	antibiotics	338:348	arg1	development					304:314	the slow development	295:314	the slow development of new small-molecule antibiotics	295:348	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	5	74	theme	Eudragit®	1033:1041	arg1	excipient					1112:1120	a stabilizing excipient	1098:1120	a stabilizing excipient for a possible active component	1098:1152	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	5	74	theme	Eudragit®	1033:1041	arg1	coating					1073:1079	a protective particle coating	1051:1079	a protective particle coating	1051:1079	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	5	74	theme	Eudragit®	1033:1041	arg1	S100					1043:1046	Eudragit® S100	1033:1046	Eudragit® S100	1033:1046	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	9	75	theme	Eudragit	1902:1909	arg1	%					1893:1893	higher than 5%	1880:1893	higher than 5% w/w of Eudragit	1880:1909	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	9	75	theme	Eudragit	1902:1909	arg1	Eudragit					1902:1909	Eudragit	1902:1909	Eudragit	1902:1909	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	4	76	theme	low	841:843	arg1	conditions					848:857	low pH conditions	841:857	low pH conditions	841:857	Encapsulation of the therapeutics within a pH-responsive coating capable of surviving low pH conditions has the potential to provide such protection.
34742827	9	77	with	particles	1865:1873	arg1	%					1893:1893	higher than 5%	1880:1893	higher than 5% w/w of Eudragit	1880:1909	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	9	77	with	particles	1865:1873	arg1	Eudragit					1902:1909	Eudragit	1902:1909	Eudragit	1902:1909	The trehalose cores of particles with higher than 5% w/w of Eudragit remained protected after one hour of exposure at pH 2, indicating the potential of Eudragit-trehalose formulations for enteric delivery of drugs.
34742827	5	78	theme	comparable	993:1002	arg1	pH					990:991	low pH	986:991	low pH comparable to stomach conditions	986:1024	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	2	79	theme	infections	461:470	arg1	treatment					440:448	the treatment	436:448	the treatment of enteric infections	436:470	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	5	80	theme	stomach	1007:1013	arg1	conditions					1015:1024	stomach conditions	1007:1024	stomach conditions	1007:1024	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	0	81	theme	eudragit-trehalose	34:51	arg1	feasibility					7:17	the feasibility	3:17	the feasibility of spray-dried eudragit-trehalose	3:51	On the feasibility of spray-dried eudragit-trehalose microparticles for enteric drug delivery.
34742827	7	82	theme	imaging	1657:1663	arg1	method					1665:1670	a new shadowgraphic imaging method	1637:1670	a new shadowgraphic imaging method	1637:1670	Promising Eudragit-trehalose formulations were subsequently spray-dried and their survival in acidic and alkaline environments studied using a new shadowgraphic imaging method.
34742827	6	83	theme	monodisperse	1188:1199	arg1	technique					1215:1223	a monodisperse droplet chain technique	1186:1223	a monodisperse droplet chain technique	1186:1223	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	4	84	theme	such	888:891	arg1	protection					893:902	such protection	888:902	such protection	888:902	Encapsulation of the therapeutics within a pH-responsive coating capable of surviving low pH conditions has the potential to provide such protection.
34742827	7	85	theme	new	1639:1641	arg1	method					1665:1670	a new shadowgraphic imaging method	1637:1670	a new shadowgraphic imaging method	1637:1670	Promising Eudragit-trehalose formulations were subsequently spray-dried and their survival in acidic and alkaline environments studied using a new shadowgraphic imaging method.
34742827	1	86	dep	year	225:228	arg1	every					219:223	every	219:223	every	219:223	Enteric infections have long constituted a silent epidemic responsible for hundreds of thousands of deaths around the world every year.
34742827	3	87	theme	therapeutics	504:515	arg1	administration					486:499	the administration	482:499	the administration of therapeutics through the oral route to target gastrointestinal infections	482:576	However, the administration of therapeutics through the oral route to target gastrointestinal infections poses challenges to dosage formulation because these active ingredients, particularly relatively fragile biological entities, require protection from the stomach's harsh acids.
34742827	5	88	theme	protective	1053:1062	arg1	coating					1073:1079	a protective particle coating	1051:1079	a protective particle coating	1051:1079	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	5	88	theme	protective	1053:1062	arg1	S100					1043:1046	Eudragit® S100	1033:1046	Eudragit® S100	1033:1046	In this study, we developed a spray-dried powder vehicle capable of withstanding low pH comparable to stomach conditions, using Eudragit® S100 as a protective particle coating and trehalose as a stabilizing excipient for a possible active component.
34742827	2	89	from	option	426:431	arg1	treatment					440:448	the treatment	436:448	the treatment of enteric infections	436:470	Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy have become a much sought-after option in the treatment of enteric infections.
34742827	6	90	theme	formation	1166:1174	arg1	model					1176:1180	A particle formation model	1155:1180	A particle formation model	1155:1180	A particle formation model and a monodisperse droplet chain technique were initially used to study the formation process of Eudragit-trehalose composite microparticles at different ratios and in different ratios of water-ethanol solvent, which showed formation of particles with Eudragit shells varying in thickness from 0.13 μm to 0.75 μm.
34742827	1	91	dep	world	213:217	arg1	year					225:228	year	225:228	year	225:228	Enteric infections have long constituted a silent epidemic responsible for hundreds of thousands of deaths around the world every year.
34742827	3	92	theme	target	543:548	arg1	infections					567:576	target gastrointestinal infections	543:576	target gastrointestinal infections	543:576	However, the administration of therapeutics through the oral route to target gastrointestinal infections poses challenges to dosage formulation because these active ingredients, particularly relatively fragile biological entities, require protection from the stomach's harsh acids.
32068946	9	0	theme	surface	1231:1237	arg1	assay					1274:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay	1203:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay	1203:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay also showed that pingyangmycin changed cell surface glycosaminoglycan structures.
32068946	9	1	theme	surface	1324:1330	arg1	structures					1350:1359	cell surface glycosaminoglycan structures	1319:1359	cell surface glycosaminoglycan structures	1319:1359	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay also showed that pingyangmycin changed cell surface glycosaminoglycan structures.
32068946	4	2	theme	pingyangmycin	553:565	arg1	effect					575:580	its effect	571:580	its effect on glycosaminoglycan biosynthesis	571:614	Seven cell lines and a Lewis lung carcinoma-injected C57BL/6 mouse model were used to understand the cytotoxicity of pingyangmycin and its effect on glycosaminoglycan biosynthesis.
32068946	4	2	theme	pingyangmycin	553:565	arg1	cytotoxicity					537:548	the cytotoxicity	533:548	the cytotoxicity of pingyangmycin	533:565	Seven cell lines and a Lewis lung carcinoma-injected C57BL/6 mouse model were used to understand the cytotoxicity of pingyangmycin and its effect on glycosaminoglycan biosynthesis.
32068946	8	3	theme	chlorate	1193:1200	arg1	presence					1181:1188	the presence	1177:1188	the presence of chlorate	1177:1200	Moreover, the cytotoxicity of pingyangmycin was decreased in the presence of soluble glycosaminoglycans, in the glycosaminoglycan-deficient cell line CHO745, and in the presence of chlorate.
32068946	1	4	from	fibrosis	161:168	arg1	patients					188:195	certain cancer patients	173:195	certain cancer patients	173:195	Pingyangmycin is a clinically used anticancer drug and induces lung fibrosis in certain cancer patients.
32068946	7	5	theme	different	986:994	arg1	times					1005:1009	different exposure times	986:1009	different exposure times	986:1009	The effect was persistent at different pingyangmycin concentrations and at different exposure times.
32068946	4	6	from	cytotoxicity	537:548	arg1	biosynthesis					603:614	glycosaminoglycan biosynthesis	585:614	glycosaminoglycan biosynthesis	585:614	Seven cell lines and a Lewis lung carcinoma-injected C57BL/6 mouse model were used to understand the cytotoxicity of pingyangmycin and its effect on glycosaminoglycan biosynthesis.
32068946	8	7	theme	soluble	1089:1095	arg1	glycosaminoglycans					1097:1114	soluble glycosaminoglycans	1089:1114	soluble glycosaminoglycans	1089:1114	Moreover, the cytotoxicity of pingyangmycin was decreased in the presence of soluble glycosaminoglycans, in the glycosaminoglycan-deficient cell line CHO745, and in the presence of chlorate.
32068946	7	8	theme	exposure	996:1003	arg1	times					1005:1009	different exposure times	986:1009	different exposure times	986:1009	The effect was persistent at different pingyangmycin concentrations and at different exposure times.
32068946	5	9	from	samples	790:796	arg1	compositions					720:731	glycosaminoglycan disaccharide compositions	689:731	glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples	689:796	Stable isotope labelling coupled with LC/MS method was used to quantify glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples.
32068946	2	10	theme	cellular	301:308	arg1	uptake					310:315	the cellular uptake	297:315	the cellular uptake of the positively charged pingyangmycin	297:355	We previously reported that the negatively charged cell surface glycosaminoglycans are involved in the cellular uptake of the positively charged pingyangmycin.
32068946	8	11	theme	glycosaminoglycans	1097:1114	arg1	presence					1077:1084	the presence	1073:1084	the presence of soluble glycosaminoglycans	1073:1114	Moreover, the cytotoxicity of pingyangmycin was decreased in the presence of soluble glycosaminoglycans, in the glycosaminoglycan-deficient cell line CHO745, and in the presence of chlorate.
32068946	10	12	theme	cancer	1473:1478	arg1	patients					1480:1487	certain cancer patients	1465:1487	certain cancer patients	1465:1487	Changes in the structures of glycosaminoglycans may be related to fibrosis induced by pingyangmycin in certain cancer patients.
32068946	4	13	theme	cell	442:445	arg1	lines					447:451	Seven cell lines	436:451	Seven cell lines	436:451	Seven cell lines and a Lewis lung carcinoma-injected C57BL/6 mouse model were used to understand the cytotoxicity of pingyangmycin and its effect on glycosaminoglycan biosynthesis.
32068946	7	14	from	times	1005:1009	arg1	persistent					926:935	persistent	926:935	persistent	926:935	The effect was persistent at different pingyangmycin concentrations and at different exposure times.
32068946	10	15	theme	certain	1465:1471	arg1	patients					1480:1487	certain cancer patients	1465:1487	certain cancer patients	1465:1487	Changes in the structures of glycosaminoglycans may be related to fibrosis induced by pingyangmycin in certain cancer patients.
32068946	1	16	theme	certain	173:179	arg1	patients					188:195	certain cancer patients	173:195	certain cancer patients	173:195	Pingyangmycin is a clinically used anticancer drug and induces lung fibrosis in certain cancer patients.
32068946	0	17	theme	cancer	60:65	arg1	cells					67:71	cancer cells	60:71	cancer cells	60:71	Pingyangmycin inhibits glycosaminoglycan sulphation in both cancer cells and tumour tissues.
32068946	5	18	theme	isotope	624:630	arg1	labelling					632:640	Stable isotope labelling	617:640	Stable isotope labelling coupled with LC/MS method	617:666	Stable isotope labelling coupled with LC/MS method was used to quantify glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples.
32068946	7	19	theme	pingyangmycin	950:962	arg1	concentrations					964:977	different pingyangmycin concentrations	940:977	different pingyangmycin concentrations	940:977	The effect was persistent at different pingyangmycin concentrations and at different exposure times.
32068946	1	20	theme	cancer	181:186	arg1	patients					188:195	certain cancer patients	173:195	certain cancer patients	173:195	Pingyangmycin is a clinically used anticancer drug and induces lung fibrosis in certain cancer patients.
32068946	3	21	theme	glycosaminoglycan	406:422	arg1	structures					424:433	glycosaminoglycan structures	406:433	glycosaminoglycan structures	406:433	However, it is unknown if pingyangmycin affects glycosaminoglycan structures.
32068946	5	22	theme	glycosaminoglycan	689:705	arg1	compositions					720:731	glycosaminoglycan disaccharide compositions	689:731	glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples	689:796	Stable isotope labelling coupled with LC/MS method was used to quantify glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples.
32068946	2	23	theme	charged	335:341	arg1	pingyangmycin					343:355	the positively charged pingyangmycin	320:355	the positively charged pingyangmycin	320:355	We previously reported that the negatively charged cell surface glycosaminoglycans are involved in the cellular uptake of the positively charged pingyangmycin.
32068946	9	24	theme	cytometry-based	1210:1224	arg1	assay					1274:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay	1203:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay	1203:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay also showed that pingyangmycin changed cell surface glycosaminoglycan structures.
32068946	5	25	theme	disaccharide	707:718	arg1	compositions					720:731	glycosaminoglycan disaccharide compositions	689:731	glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples	689:796	Stable isotope labelling coupled with LC/MS method was used to quantify glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples.
32068946	5	26	used	used	672:675	arg2	labelling					632:640	Stable isotope labelling	617:640	Stable isotope labelling coupled with LC/MS method	617:666	Stable isotope labelling coupled with LC/MS method was used to quantify glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples.
32068946	4	27	theme	glycosaminoglycan	585:601	arg1	biosynthesis					603:614	glycosaminoglycan biosynthesis	585:614	glycosaminoglycan biosynthesis	585:614	Seven cell lines and a Lewis lung carcinoma-injected C57BL/6 mouse model were used to understand the cytotoxicity of pingyangmycin and its effect on glycosaminoglycan biosynthesis.
32068946	6	28	theme	cancer	882:887	arg1	cells					889:893	cancer cells	882:893	cancer cells	882:893	Pingyangmycin reduced both chondroitin sulphate and heparan sulphate sulphation in cancer cells and in tumours.
32068946	5	29	theme	LC/MS	655:659	arg1	method					661:666	LC/MS method	655:666	LC/MS method	655:666	Stable isotope labelling coupled with LC/MS method was used to quantify glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples.
32068946	0	30	theme	glycosaminoglycan	23:39	arg1	sulphation					41:50	glycosaminoglycan sulphation	23:50	glycosaminoglycan sulphation in both cancer cells and tumour tissues	23:90	Pingyangmycin inhibits glycosaminoglycan sulphation in both cancer cells and tumour tissues.
32068946	4	31	theme	C57BL/6	489:495	arg1	model					503:507	a Lewis lung carcinoma-injected C57BL/6 mouse model	457:507	a Lewis lung carcinoma-injected C57BL/6 mouse model	457:507	Seven cell lines and a Lewis lung carcinoma-injected C57BL/6 mouse model were used to understand the cytotoxicity of pingyangmycin and its effect on glycosaminoglycan biosynthesis.
32068946	9	32	theme	FGF/FGFR/glycosaminoglycan	1239:1264	arg1	assay					1274:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay	1203:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay	1203:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay also showed that pingyangmycin changed cell surface glycosaminoglycan structures.
32068946	9	33	theme	cell	1226:1229	arg1	assay					1274:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay	1203:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay	1203:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay also showed that pingyangmycin changed cell surface glycosaminoglycan structures.
32068946	10	34	from	Changes	1362:1368	arg1	structures					1377:1386	the structures	1373:1386	the structures of glycosaminoglycans	1373:1408	Changes in the structures of glycosaminoglycans may be related to fibrosis induced by pingyangmycin in certain cancer patients.
32068946	4	35	theme	carcinoma-injected	470:487	arg1	model					503:507	a Lewis lung carcinoma-injected C57BL/6 mouse model	457:507	a Lewis lung carcinoma-injected C57BL/6 mouse model	457:507	Seven cell lines and a Lewis lung carcinoma-injected C57BL/6 mouse model were used to understand the cytotoxicity of pingyangmycin and its effect on glycosaminoglycan biosynthesis.
32068946	2	36	theme	cell	249:252	arg1	glycosaminoglycans					262:279	the negatively charged cell surface glycosaminoglycans	226:279	the negatively charged cell surface glycosaminoglycans	226:279	We previously reported that the negatively charged cell surface glycosaminoglycans are involved in the cellular uptake of the positively charged pingyangmycin.
32068946	9	37	theme	binding	1266:1272	arg1	assay					1274:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay	1203:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay	1203:1278	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay also showed that pingyangmycin changed cell surface glycosaminoglycan structures.
32068946	6	38	theme	heparan	851:857	arg1	sulphate					859:866	heparan sulphate	851:866	heparan sulphate	851:866	Pingyangmycin reduced both chondroitin sulphate and heparan sulphate sulphation in cancer cells and in tumours.
32068946	4	39	from	effect	575:580	arg1	biosynthesis					603:614	glycosaminoglycan biosynthesis	585:614	glycosaminoglycan biosynthesis	585:614	Seven cell lines and a Lewis lung carcinoma-injected C57BL/6 mouse model were used to understand the cytotoxicity of pingyangmycin and its effect on glycosaminoglycan biosynthesis.
32068946	9	40	theme	glycosaminoglycan	1332:1348	arg1	structures					1350:1359	cell surface glycosaminoglycan structures	1319:1359	cell surface glycosaminoglycan structures	1319:1359	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay also showed that pingyangmycin changed cell surface glycosaminoglycan structures.
32068946	2	41	theme	charged	241:247	arg1	glycosaminoglycans					262:279	the negatively charged cell surface glycosaminoglycans	226:279	the negatively charged cell surface glycosaminoglycans	226:279	We previously reported that the negatively charged cell surface glycosaminoglycans are involved in the cellular uptake of the positively charged pingyangmycin.
32068946	8	42	theme	pingyangmycin	1042:1054	arg1	cytotoxicity					1026:1037	the cytotoxicity	1022:1037	the cytotoxicity of pingyangmycin	1022:1054	Moreover, the cytotoxicity of pingyangmycin was decreased in the presence of soluble glycosaminoglycans, in the glycosaminoglycan-deficient cell line CHO745, and in the presence of chlorate.
32068946	7	43	theme	different	940:948	arg1	concentrations					964:977	different pingyangmycin concentrations	940:977	different pingyangmycin concentrations	940:977	The effect was persistent at different pingyangmycin concentrations and at different exposure times.
32068946	5	44	theme	untreated	764:772	arg1	cell					774:777	pingyangmycin-treated and untreated cell and tumour samples	738:796	cell	774:777	Stable isotope labelling coupled with LC/MS method was used to quantify glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples.
32068946	4	45	theme	mouse	497:501	arg1	model					503:507	a Lewis lung carcinoma-injected C57BL/6 mouse model	457:507	a Lewis lung carcinoma-injected C57BL/6 mouse model	457:507	Seven cell lines and a Lewis lung carcinoma-injected C57BL/6 mouse model were used to understand the cytotoxicity of pingyangmycin and its effect on glycosaminoglycan biosynthesis.
32068946	1	46	theme	used	123:126	arg1	drug					139:142	a clinically used anticancer drug	110:142	a clinically used anticancer drug	110:142	Pingyangmycin is a clinically used anticancer drug and induces lung fibrosis in certain cancer patients.
32068946	1	46	theme	used	123:126	arg1	Pingyangmycin					93:105	Pingyangmycin	93:105	Pingyangmycin	93:105	Pingyangmycin is a clinically used anticancer drug and induces lung fibrosis in certain cancer patients.
32068946	4	47	used	used	514:517	arg2	lines					447:451	Seven cell lines	436:451	Seven cell lines	436:451	Seven cell lines and a Lewis lung carcinoma-injected C57BL/6 mouse model were used to understand the cytotoxicity of pingyangmycin and its effect on glycosaminoglycan biosynthesis.
32068946	4	47	used	used	514:517	arg2	model					503:507	a Lewis lung carcinoma-injected C57BL/6 mouse model	457:507	a Lewis lung carcinoma-injected C57BL/6 mouse model	457:507	Seven cell lines and a Lewis lung carcinoma-injected C57BL/6 mouse model were used to understand the cytotoxicity of pingyangmycin and its effect on glycosaminoglycan biosynthesis.
32068946	5	48	theme	pingyangmycin-treated	738:758	arg1	cell					774:777	pingyangmycin-treated and untreated cell and tumour samples	738:796	cell	774:777	Stable isotope labelling coupled with LC/MS method was used to quantify glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples.
32068946	1	49	theme	anticancer	128:137	arg1	drug					139:142	a clinically used anticancer drug	110:142	a clinically used anticancer drug	110:142	Pingyangmycin is a clinically used anticancer drug and induces lung fibrosis in certain cancer patients.
32068946	1	49	theme	anticancer	128:137	arg1	Pingyangmycin					93:105	Pingyangmycin	93:105	Pingyangmycin	93:105	Pingyangmycin is a clinically used anticancer drug and induces lung fibrosis in certain cancer patients.
32068946	8	50	theme	cell	1152:1155	arg1	line					1157:1160	the glycosaminoglycan-deficient cell line CHO745	1120:1167	the glycosaminoglycan-deficient cell line CHO745	1120:1167	Moreover, the cytotoxicity of pingyangmycin was decreased in the presence of soluble glycosaminoglycans, in the glycosaminoglycan-deficient cell line CHO745, and in the presence of chlorate.
32068946	8	51	theme	glycosaminoglycan-deficient	1124:1150	arg1	line					1157:1160	the glycosaminoglycan-deficient cell line CHO745	1120:1167	the glycosaminoglycan-deficient cell line CHO745	1120:1167	Moreover, the cytotoxicity of pingyangmycin was decreased in the presence of soluble glycosaminoglycans, in the glycosaminoglycan-deficient cell line CHO745, and in the presence of chlorate.
32068946	5	52	theme	Stable	617:622	arg1	labelling					632:640	Stable isotope labelling	617:640	Stable isotope labelling coupled with LC/MS method	617:666	Stable isotope labelling coupled with LC/MS method was used to quantify glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples.
32068946	9	53	theme	cell	1319:1322	arg1	structures					1350:1359	cell surface glycosaminoglycan structures	1319:1359	cell surface glycosaminoglycan structures	1319:1359	A flow cytometry-based cell surface FGF/FGFR/glycosaminoglycan binding assay also showed that pingyangmycin changed cell surface glycosaminoglycan structures.
32068946	5	54	theme	tumour	783:788	arg1	samples					790:796	pingyangmycin-treated and untreated cell and tumour samples	738:796	samples	790:796	Stable isotope labelling coupled with LC/MS method was used to quantify glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples.
32068946	4	55	theme	lung	465:468	arg1	model					503:507	a Lewis lung carcinoma-injected C57BL/6 mouse model	457:507	a Lewis lung carcinoma-injected C57BL/6 mouse model	457:507	Seven cell lines and a Lewis lung carcinoma-injected C57BL/6 mouse model were used to understand the cytotoxicity of pingyangmycin and its effect on glycosaminoglycan biosynthesis.
32068946	7	56	from	concentrations	964:977	arg1	persistent					926:935	persistent	926:935	persistent	926:935	The effect was persistent at different pingyangmycin concentrations and at different exposure times.
32068946	7	56	from	concentrations	964:977	arg1	effect					915:920	The effect	911:920	The effect	911:920	The effect was persistent at different pingyangmycin concentrations and at different exposure times.
32068946	2	57	theme	pingyangmycin	343:355	arg1	uptake					310:315	the cellular uptake	297:315	the cellular uptake of the positively charged pingyangmycin	297:355	We previously reported that the negatively charged cell surface glycosaminoglycans are involved in the cellular uptake of the positively charged pingyangmycin.
32068946	0	58	theme	tumour	77:82	arg1	tissues					84:90	tumour tissues	77:90	tumour tissues	77:90	Pingyangmycin inhibits glycosaminoglycan sulphation in both cancer cells and tumour tissues.
32068946	4	59	theme	Lewis	459:463	arg1	model					503:507	a Lewis lung carcinoma-injected C57BL/6 mouse model	457:507	a Lewis lung carcinoma-injected C57BL/6 mouse model	457:507	Seven cell lines and a Lewis lung carcinoma-injected C57BL/6 mouse model were used to understand the cytotoxicity of pingyangmycin and its effect on glycosaminoglycan biosynthesis.
32068946	10	60	theme	glycosaminoglycans	1391:1408	arg1	structures					1377:1386	the structures	1373:1386	the structures of glycosaminoglycans	1373:1408	Changes in the structures of glycosaminoglycans may be related to fibrosis induced by pingyangmycin in certain cancer patients.
32068946	0	61	from	sulphation	41:50	arg1	tissues					84:90	tumour tissues	77:90	tumour tissues	77:90	Pingyangmycin inhibits glycosaminoglycan sulphation in both cancer cells and tumour tissues.
32068946	0	61	from	sulphation	41:50	arg1	cells					67:71	cancer cells	60:71	cancer cells	60:71	Pingyangmycin inhibits glycosaminoglycan sulphation in both cancer cells and tumour tissues.
32068946	2	62	theme	surface	254:260	arg1	glycosaminoglycans					262:279	the negatively charged cell surface glycosaminoglycans	226:279	the negatively charged cell surface glycosaminoglycans	226:279	We previously reported that the negatively charged cell surface glycosaminoglycans are involved in the cellular uptake of the positively charged pingyangmycin.
32068946	6	63	theme	chondroitin	826:836	arg1	sulphate					838:845	chondroitin sulphate	826:845	chondroitin sulphate	826:845	Pingyangmycin reduced both chondroitin sulphate and heparan sulphate sulphation in cancer cells and in tumours.
32068946	1	64	theme	lung	156:159	arg1	fibrosis					161:168	lung fibrosis	156:168	lung fibrosis in certain cancer patients	156:195	Pingyangmycin is a clinically used anticancer drug and induces lung fibrosis in certain cancer patients.
32068946	5	65	from	cell	774:777	arg1	compositions					720:731	glycosaminoglycan disaccharide compositions	689:731	glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples	689:796	Stable isotope labelling coupled with LC/MS method was used to quantify glycosaminoglycan disaccharide compositions from pingyangmycin-treated and untreated cell and tumour samples.
34350725	0	0	theme	calcium	93:99	arg1	coating					120:126	calcium phosphate/chitosan coating	93:126	calcium phosphate/chitosan coating	93:126	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating promotes long-term bone tissue regeneration.
34350725	2	1	theme	water	655:659	arg1	ratio					646:650	the ratio	642:650	the ratio of water to ethanol	642:670	MAIN METHODS AND MAJOR RESULTS The results showed that the binding force and bioactivity of CaP-CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm-2 .
34350725	5	2	theme	osteogenic	1165:1174	arg1	differentiation					1176:1190	RMSC osteogenic differentiation	1160:1190	RMSC osteogenic differentiation	1160:1190	CONCLUSIONS AND IMPLICATIONS CaP-CS/MAO/AZ91D was established to promote RMSC osteogenic differentiation within a proper range for at least 90 days through Wnt/β-catenin pathway activation, which would allow sufficient time for bone healing.
34350725	6	3	theme	CaP-CS/MAO/AZ91D	1373:1388	arg1	coating					1390:1396	the CaP-CS/MAO/AZ91D coating	1369:1396	the CaP-CS/MAO/AZ91D coating	1369:1396	Collectively, our findings suggest that the CaP-CS/MAO/AZ91D coating could not only reduce the corrosion rate and lead to better long-term biocompatibility but also promote osteogenic mineralization.
34350725	5	4	theme	bone	1315:1318	arg1	healing					1320:1326	bone healing	1315:1326	bone healing	1315:1326	CONCLUSIONS AND IMPLICATIONS CaP-CS/MAO/AZ91D was established to promote RMSC osteogenic differentiation within a proper range for at least 90 days through Wnt/β-catenin pathway activation, which would allow sufficient time for bone healing.
34350725	4	5	theme	mesenchymal	904:914	arg1	RMSC					928:931	RMSC	928:931	RMSC	928:931	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	4	5	theme	mesenchymal	904:914	arg1	cells					921:925	rat mesenchymal stem cells	900:925	rat mesenchymal stem cells (RMSC)	900:932	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	2	6	theme	MAJOR	534:538	arg1	RESULTS					540:546	MAJOR RESULTS	534:546	MAJOR RESULTS	534:546	MAIN METHODS AND MAJOR RESULTS The results showed that the binding force and bioactivity of CaP-CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm-2 .
34350725	4	7	theme	rat	900:902	arg1	RMSC					928:931	RMSC	928:931	RMSC	928:931	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	4	7	theme	rat	900:902	arg1	cells					921:925	rat mesenchymal stem cells	900:925	rat mesenchymal stem cells (RMSC)	900:932	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	1	8	theme	bone	483:486	arg1	ability					508:514	its mechanical property and long-term bone tissue regeneration ability	445:514	ability	508:514	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	4	9	theme	stem	916:919	arg1	RMSC					928:931	RMSC	928:931	RMSC	928:931	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	4	9	theme	stem	916:919	arg1	cells					921:925	rat mesenchymal stem cells	900:925	rat mesenchymal stem cells (RMSC)	900:932	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	6	10	dep	could	1398:1402	arg1	only					1408:1411	only	1408:1411	only	1408:1411	Collectively, our findings suggest that the CaP-CS/MAO/AZ91D coating could not only reduce the corrosion rate and lead to better long-term biocompatibility but also promote osteogenic mineralization.
34350725	1	11	theme	alloy	280:284	arg1	ability					254:260	the long-term osteogenic ability	229:260	the long-term osteogenic ability of magnesium (Mg) alloy	229:284	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	2	12	theme	binding	576:582	arg1	force					584:588	the binding force	572:588	the binding force	572:588	MAIN METHODS AND MAJOR RESULTS The results showed that the binding force and bioactivity of CaP-CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm-2 .
34350725	2	12	theme	binding	576:582	arg1	better					630:635	better	630:635	better	630:635	MAIN METHODS AND MAJOR RESULTS The results showed that the binding force and bioactivity of CaP-CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm-2 .
34350725	1	13	theme	calcium	374:380	arg1	coating					401:407	calcium phosphate/chitosan coating	374:407	calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D)	374:426	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	1	13	theme	calcium	374:380	arg1	CaP-CS/MAO/AZ91D					410:425	CaP-CS/MAO/AZ91D	410:425	CaP-CS/MAO/AZ91D	410:425	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	4	14	theme	cells	921:925	arg1	proliferation					883:895	proliferation	883:895	proliferation	883:895	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	4	14	theme	cells	921:925	arg1	differentiation					863:877	differentiation	863:877	differentiation	863:877	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	1	15	theme	tissue	488:493	arg1	ability					508:514	its mechanical property and long-term bone tissue regeneration ability	445:514	ability	508:514	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	1	16	with	implant	361:367	arg1	coating					401:407	calcium phosphate/chitosan coating	374:407	calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D)	374:426	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	1	16	with	implant	361:367	arg1	CaP-CS/MAO/AZ91D					410:425	CaP-CS/MAO/AZ91D	410:425	CaP-CS/MAO/AZ91D	410:425	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	0	17	theme	phosphate/chitosan	101:118	arg1	coating					120:126	calcium phosphate/chitosan coating	93:126	calcium phosphate/chitosan coating	93:126	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating promotes long-term bone tissue regeneration.
34350725	1	18	theme	phosphate/chitosan	382:399	arg1	coating					401:407	calcium phosphate/chitosan coating	374:407	calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D)	374:426	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	1	18	theme	phosphate/chitosan	382:399	arg1	CaP-CS/MAO/AZ91D					410:425	CaP-CS/MAO/AZ91D	410:425	CaP-CS/MAO/AZ91D	410:425	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	2	19	dep	METHODS	522:528	arg1	showed					560:565	showed	560:565	showed that the binding force and bioactivity of CaP-CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm-2	560:718	MAIN METHODS AND MAJOR RESULTS The results showed that the binding force and bioactivity of CaP-CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm-2 .
34350725	1	20	theme	regeneration	495:506	arg1	ability					508:514	its mechanical property and long-term bone tissue regeneration ability	445:514	ability	508:514	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	0	21	theme	long-term	137:145	arg1	regeneration					159:170	long-term bone tissue regeneration	137:170	long-term bone tissue regeneration	137:170	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating promotes long-term bone tissue regeneration.
34350725	1	22	theme	biodegradable	198:210	arg1	rate					212:215	the biodegradable rate	194:215	the biodegradable rate	194:215	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	4	23	theme	phosphatase	1030:1040	arg1	activity					1042:1049	early alkaline phosphatase activity	1015:1049	early alkaline phosphatase activity	1015:1049	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	3	24	theme	4:6	747:749	arg1	sample					751:756	4:6 sample	747:756	4:6 sample	747:756	Compressive strengths of 4:6 sample were more than 1300 N when the soaking time was increased to 21 days.
34350725	4	25	theme	alkaline	1021:1028	arg1	phosphatase					1030:1040	early alkaline phosphatase	1015:1040	early alkaline phosphatase activity	1015:1049	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	0	26	theme	biodegradable	2:14	arg1	implant					80:86	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant	0:86	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating	0:126	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating promotes long-term bone tissue regeneration.
34350725	3	27	theme	sample	751:756	arg1	strengths					734:742	Compressive strengths	722:742	Compressive strengths of 4:6 sample	722:756	Compressive strengths of 4:6 sample were more than 1300 N when the soaking time was increased to 21 days.
34350725	2	28	theme	A	713:713	arg1	cm-2					715:718	0.1 A cm-2	709:718	0.1 A cm-2	709:718	MAIN METHODS AND MAJOR RESULTS The results showed that the binding force and bioactivity of CaP-CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm-2 .
34350725	2	29	theme	MAO	684:686	arg1	current					697:703	MAO constant current	684:703	MAO constant current	684:703	MAIN METHODS AND MAJOR RESULTS The results showed that the binding force and bioactivity of CaP-CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm-2 .
34350725	5	30	theme	pathway	1257:1263	arg1	activation					1265:1274	Wnt/β-catenin pathway activation	1243:1274	Wnt/β-catenin pathway activation	1243:1274	CONCLUSIONS AND IMPLICATIONS CaP-CS/MAO/AZ91D was established to promote RMSC osteogenic differentiation within a proper range for at least 90 days through Wnt/β-catenin pathway activation, which would allow sufficient time for bone healing.
34350725	5	31	theme	proper	1201:1206	arg1	range					1208:1212	a proper range	1199:1212	a proper range for at least 90 days	1199:1233	CONCLUSIONS AND IMPLICATIONS CaP-CS/MAO/AZ91D was established to promote RMSC osteogenic differentiation within a proper range for at least 90 days through Wnt/β-catenin pathway activation, which would allow sufficient time for bone healing.
34350725	4	32	theme	sialoprotein	1065:1076	arg1	markers					1078:1084	late bone sialoprotein markers	1055:1084	late bone sialoprotein markers	1055:1084	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	3	33	theme	Compressive	722:732	arg1	strengths					734:742	Compressive strengths	722:742	Compressive strengths of 4:6 sample	722:756	Compressive strengths of 4:6 sample were more than 1300 N when the soaking time was increased to 21 days.
34350725	0	34	theme	tissue	152:157	arg1	regeneration					159:170	long-term bone tissue regeneration	137:170	long-term bone tissue regeneration	137:170	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating promotes long-term bone tissue regeneration.
34350725	4	35	theme	bone	1060:1063	arg1	markers					1078:1084	late bone sialoprotein markers	1055:1084	late bone sialoprotein markers	1055:1084	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	1	36	theme	new	301:303	arg1	implant					361:367	a new biodegradable micro arc oxidation AZ91D-based composite implant	299:367	a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D)	299:426	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	0	37	theme	bone	147:150	arg1	regeneration					159:170	long-term bone tissue regeneration	137:170	long-term bone tissue regeneration	137:170	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating promotes long-term bone tissue regeneration.
34350725	5	38	theme	IMPLICATIONS	1103:1114	arg1	CaP-CS/MAO/AZ91D					1116:1131	CONCLUSIONS AND IMPLICATIONS CaP-CS/MAO/AZ91D	1087:1131	CONCLUSIONS AND IMPLICATIONS CaP-CS/MAO/AZ91D	1087:1131	CONCLUSIONS AND IMPLICATIONS CaP-CS/MAO/AZ91D was established to promote RMSC osteogenic differentiation within a proper range for at least 90 days through Wnt/β-catenin pathway activation, which would allow sufficient time for bone healing.
34350725	2	39	theme	MAIN	517:520	arg1	METHODS					522:528	MAIN METHODS	517:528	MAIN METHODS	517:528	MAIN METHODS AND MAJOR RESULTS The results showed that the binding force and bioactivity of CaP-CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm-2 .
34350725	1	40	theme	long-term	233:241	arg1	ability					254:260	the long-term osteogenic ability	229:260	the long-term osteogenic ability of magnesium (Mg) alloy	229:284	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	0	41	theme	micro-arc	38:46	arg1	implant					80:86	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant	0:86	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating	0:126	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating promotes long-term bone tissue regeneration.
34350725	1	42	theme	biodegradable	305:317	arg1	implant					361:367	a new biodegradable micro arc oxidation AZ91D-based composite implant	299:367	a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D)	299:426	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	4	43	theme	proliferation	957:969	arg1	rates					971:975	higher proliferation rates	950:975	higher proliferation rates	950:975	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	4	44	theme	CaP-CS/MAO/AZ91D	828:843	arg1	extracts					845:852	CaP-CS/MAO/AZ91D extracts	828:852	CaP-CS/MAO/AZ91D extracts	828:852	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	1	45	theme	osteogenic	243:252	arg1	ability					254:260	the long-term osteogenic ability	229:260	the long-term osteogenic ability of magnesium (Mg) alloy	229:284	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	4	46	theme	early	1015:1019	arg1	phosphatase					1030:1040	early alkaline phosphatase	1015:1040	early alkaline phosphatase activity	1015:1049	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	1	47	theme	micro	319:323	arg1	implant					361:367	a new biodegradable micro arc oxidation AZ91D-based composite implant	299:367	a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D)	299:426	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	4	48	theme	higher	950:955	arg1	rates					971:975	higher proliferation rates	950:975	higher proliferation rates	950:975	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	6	49	theme	osteogenic	1502:1511	arg1	mineralization					1513:1526	osteogenic mineralization	1502:1526	osteogenic mineralization	1502:1526	Collectively, our findings suggest that the CaP-CS/MAO/AZ91D coating could not only reduce the corrosion rate and lead to better long-term biocompatibility but also promote osteogenic mineralization.
34350725	5	50	theme	Wnt/β-catenin	1243:1255	arg1	activation					1265:1274	Wnt/β-catenin pathway activation	1243:1274	Wnt/β-catenin pathway activation	1243:1274	CONCLUSIONS AND IMPLICATIONS CaP-CS/MAO/AZ91D was established to promote RMSC osteogenic differentiation within a proper range for at least 90 days through Wnt/β-catenin pathway activation, which would allow sufficient time for bone healing.
34350725	3	51	theme	soaking	789:795	arg1	time					797:800	the soaking time	785:800	the soaking time	785:800	Compressive strengths of 4:6 sample were more than 1300 N when the soaking time was increased to 21 days.
34350725	0	52	theme	AZ91D-based	58:68	arg1	implant					80:86	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant	0:86	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating	0:126	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating promotes long-term bone tissue regeneration.
34350725	1	53	theme	arc	325:327	arg1	implant					361:367	a new biodegradable micro arc oxidation AZ91D-based composite implant	299:367	a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D)	299:426	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	0	54	with	implant	80:86	arg1	coating					120:126	calcium phosphate/chitosan coating	93:126	calcium phosphate/chitosan coating	93:126	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating promotes long-term bone tissue regeneration.
34350725	5	55	theme	RMSC	1160:1163	arg1	differentiation					1176:1190	RMSC osteogenic differentiation	1160:1190	RMSC osteogenic differentiation	1160:1190	CONCLUSIONS AND IMPLICATIONS CaP-CS/MAO/AZ91D was established to promote RMSC osteogenic differentiation within a proper range for at least 90 days through Wnt/β-catenin pathway activation, which would allow sufficient time for bone healing.
34350725	0	56	theme	oxidation	48:56	arg1	implant					80:86	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant	0:86	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating	0:126	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating promotes long-term bone tissue regeneration.
34350725	1	57	theme	oxidation	329:337	arg1	implant					361:367	a new biodegradable micro arc oxidation AZ91D-based composite implant	299:367	a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D)	299:426	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	1	58	theme	mechanical	449:458	arg1	property					460:467	its mechanical property and long-term bone tissue regeneration ability	445:514	property	460:467	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	1	59	theme	AZ91D-based	339:349	arg1	implant					361:367	a new biodegradable micro arc oxidation AZ91D-based composite implant	299:367	a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D)	299:426	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	2	60	theme	constant	688:695	arg1	current					697:703	MAO constant current	684:703	MAO constant current	684:703	MAIN METHODS AND MAJOR RESULTS The results showed that the binding force and bioactivity of CaP-CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm-2 .
34350725	2	61	theme	CaP-CS/MAO/AZ91D	609:624	arg1	bioactivity					594:604	bioactivity	594:604	bioactivity	594:604	MAIN METHODS AND MAJOR RESULTS The results showed that the binding force and bioactivity of CaP-CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm-2 .
34350725	2	61	theme	CaP-CS/MAO/AZ91D	609:624	arg1	force					584:588	the binding force	572:588	the binding force	572:588	MAIN METHODS AND MAJOR RESULTS The results showed that the binding force and bioactivity of CaP-CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm-2 .
34350725	2	61	theme	CaP-CS/MAO/AZ91D	609:624	arg1	better					630:635	better	630:635	better	630:635	MAIN METHODS AND MAJOR RESULTS The results showed that the binding force and bioactivity of CaP-CS/MAO/AZ91D was better when the ratio of water to ethanol was 4:6 and MAO constant current was 0.1 A cm-2 .
34350725	5	62	theme	CONCLUSIONS	1087:1097	arg1	CaP-CS/MAO/AZ91D					1116:1131	CONCLUSIONS AND IMPLICATIONS CaP-CS/MAO/AZ91D	1087:1131	CONCLUSIONS AND IMPLICATIONS CaP-CS/MAO/AZ91D	1087:1131	CONCLUSIONS AND IMPLICATIONS CaP-CS/MAO/AZ91D was established to promote RMSC osteogenic differentiation within a proper range for at least 90 days through Wnt/β-catenin pathway activation, which would allow sufficient time for bone healing.
34350725	6	63	theme	better	1451:1456	arg1	biocompatibility					1468:1483	better long-term biocompatibility	1451:1483	better long-term biocompatibility	1451:1483	Collectively, our findings suggest that the CaP-CS/MAO/AZ91D coating could not only reduce the corrosion rate and lead to better long-term biocompatibility but also promote osteogenic mineralization.
34350725	1	64	theme	magnesium	265:273	arg1	alloy					280:284	magnesium (Mg) alloy	265:284	magnesium (Mg) alloy	265:284	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	4	65	theme	culture	993:999	arg1	days					985:988	16 days	982:988	16 days of culture	982:999	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	1	66	theme	long-term	473:481	arg1	ability					508:514	its mechanical property and long-term bone tissue regeneration ability	445:514	ability	508:514	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	0	67	dep	biodegradable	2:14	arg1	tunable					30:36	tunable	30:36	tunable	30:36	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating promotes long-term bone tissue regeneration.
34350725	6	68	theme	long-term	1458:1466	arg1	biocompatibility					1468:1483	better long-term biocompatibility	1451:1483	better long-term biocompatibility	1451:1483	Collectively, our findings suggest that the CaP-CS/MAO/AZ91D coating could not only reduce the corrosion rate and lead to better long-term biocompatibility but also promote osteogenic mineralization.
34350725	5	69	theme	sufficient	1295:1304	arg1	time					1306:1309	sufficient time	1295:1309	sufficient time	1295:1309	CONCLUSIONS AND IMPLICATIONS CaP-CS/MAO/AZ91D was established to promote RMSC osteogenic differentiation within a proper range for at least 90 days through Wnt/β-catenin pathway activation, which would allow sufficient time for bone healing.
34350725	0	70	theme	composite	70:78	arg1	implant					80:86	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant	0:86	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating	0:126	A biodegradable, mechanically tunable micro-arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating promotes long-term bone tissue regeneration.
34350725	1	71	theme	composite	351:359	arg1	implant					361:367	a new biodegradable micro arc oxidation AZ91D-based composite implant	299:367	a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D)	299:426	BACKGROUND To reduce the biodegradable rate and develop the long-term osteogenic ability of magnesium (Mg) alloy, we prepared a new biodegradable micro arc oxidation AZ91D-based composite implant with calcium phosphate/chitosan coating (CaP-CS/MAO/AZ91D) and investigated its mechanical property and long-term bone tissue regeneration ability.
34350725	4	72	theme	late	1055:1058	arg1	markers					1078:1084	late bone sialoprotein markers	1055:1084	late bone sialoprotein markers	1055:1084	CaP-CS/MAO/AZ91D extracts promoted differentiation and proliferation of rat mesenchymal stem cells (RMSC), which achieved higher proliferation rates over 16 days of culture and exhibited early alkaline phosphatase activity and late bone sialoprotein markers.
34350725	6	73	theme	corrosion	1424:1432	arg1	rate					1434:1437	the corrosion rate	1420:1437	the corrosion rate	1420:1437	Collectively, our findings suggest that the CaP-CS/MAO/AZ91D coating could not only reduce the corrosion rate and lead to better long-term biocompatibility but also promote osteogenic mineralization.
32736322	0	0	theme	oleaginous	82:91	arg1	oleaginosum					119:129	the oleaginous yeast Cutaneotrichosporon oleaginosum	78:129	the oleaginous yeast Cutaneotrichosporon oleaginosum	78:129	Efficient conversion of chitin-derived carbon sources into microbial lipid by the oleaginous yeast Cutaneotrichosporon oleaginosum.
32736322	4	1	theme	lipid	509:513	arg1	accumulation					515:526	lipid accumulation	509:526	lipid accumulation by Cutaneotrichosporon oleaginosum	509:561	Here, GlcNAc was found superior to GlcN or acetate for lipid accumulation by Cutaneotrichosporon oleaginosum.
32736322	5	2	theme	lipid	568:572	arg1	potential					587:595	The lipid accumulation potential	564:595	The lipid accumulation potential of these carbon sources	564:619	The lipid accumulation potential of these carbon sources was calculated based on a small scale metabolic model of C. oleaginosum.
32736322	8	3	theme	0.25 g/g	893:900	arg1	yield					871:875	yield	871:875	yield	871:875	The highest lipid titer and yield of 10.1 g/L and 0.25 g/g, respectively, was reached when GlcNAc was used under phosphate limitation.
32736322	8	3	theme	0.25 g/g	893:900	arg1	titer					861:865	The highest lipid titer	843:865	The highest lipid titer	843:865	The highest lipid titer and yield of 10.1 g/L and 0.25 g/g, respectively, was reached when GlcNAc was used under phosphate limitation.
32736322	8	4	theme	lipid	855:859	arg1	titer					861:865	The highest lipid titer	843:865	The highest lipid titer	843:865	The highest lipid titer and yield of 10.1 g/L and 0.25 g/g, respectively, was reached when GlcNAc was used under phosphate limitation.
32736322	9	5	theme	fatty	982:986	arg1	composition					994:1004	The fatty acids composition	978:1004	The fatty acids composition of the lipid samples	978:1025	The fatty acids composition of the lipid samples showed similarities to vegetable oils, demonstrating the suitability in biodiesel industry.
32736322	4	6	theme	Cutaneotrichosporon	531:549	arg1	oleaginosum					551:561	Cutaneotrichosporon oleaginosum	531:561	Cutaneotrichosporon oleaginosum	531:561	Here, GlcNAc was found superior to GlcN or acetate for lipid accumulation by Cutaneotrichosporon oleaginosum.
32736322	5	7	theme	oleaginosum	681:691	arg1	model					669:673	a small scale metabolic model	645:673	a small scale metabolic model of C. oleaginosum	645:691	The lipid accumulation potential of these carbon sources was calculated based on a small scale metabolic model of C. oleaginosum.
32736322	0	8	link	chitin-derived	24:37	arg1	sources					46:52	chitin-derived carbon sources	24:52	chitin-derived carbon sources	24:52	Efficient conversion of chitin-derived carbon sources into microbial lipid by the oleaginous yeast Cutaneotrichosporon oleaginosum.
32736322	8	9	theme	highest	847:853	arg1	titer					861:865	The highest lipid titer	843:865	The highest lipid titer	843:865	The highest lipid titer and yield of 10.1 g/L and 0.25 g/g, respectively, was reached when GlcNAc was used under phosphate limitation.
32736322	0	10	theme	Cutaneotrichosporon	99:117	arg1	oleaginosum					119:129	the oleaginous yeast Cutaneotrichosporon oleaginosum	78:129	the oleaginous yeast Cutaneotrichosporon oleaginosum	78:129	Efficient conversion of chitin-derived carbon sources into microbial lipid by the oleaginous yeast Cutaneotrichosporon oleaginosum.
32736322	6	11	theme	improved	766:773	arg1	production					781:790	improved lipid production	766:790	improved lipid production	766:790	Co-fermentation of GlcN and acetate under phosphate limitation rendered improved lipid production.
32736322	3	12	theme	carbon	389:394	arg1	sources					396:402	these chitin-derived carbon sources	368:402	these chitin-derived carbon sources	368:402	However, these chitin-derived carbon sources have been scarcely compared for lipid production.
32736322	8	13	theme	phosphate	956:964	arg1	limitation					966:975	phosphate limitation	956:975	phosphate limitation	956:975	The highest lipid titer and yield of 10.1 g/L and 0.25 g/g, respectively, was reached when GlcNAc was used under phosphate limitation.
32736322	2	14	theme	degradation	335:345	arg1	strategies					347:356	different degradation strategies	325:356	different degradation strategies	325:356	It can be depolymerized into either N-acetylglucosamine (GlcNAc) or glucosamine (GlcN) and acetate by different degradation strategies.
32736322	5	15	theme	scale	653:657	arg1	model					669:673	a small scale metabolic model	645:673	a small scale metabolic model of C. oleaginosum	645:691	The lipid accumulation potential of these carbon sources was calculated based on a small scale metabolic model of C. oleaginosum.
32736322	5	16	theme	small	647:651	arg1	model					669:673	a small scale metabolic model	645:673	a small scale metabolic model of C. oleaginosum	645:691	The lipid accumulation potential of these carbon sources was calculated based on a small scale metabolic model of C. oleaginosum.
32736322	3	17	link	chitin-derived	374:387	arg1	sources					396:402	these chitin-derived carbon sources	368:402	these chitin-derived carbon sources	368:402	However, these chitin-derived carbon sources have been scarcely compared for lipid production.
32736322	0	18	theme	sources	46:52	arg1	conversion					10:19	Efficient conversion	0:19	Efficient conversion of chitin-derived carbon sources into microbial lipid by the oleaginous yeast Cutaneotrichosporon oleaginosum	0:129	Efficient conversion of chitin-derived carbon sources into microbial lipid by the oleaginous yeast Cutaneotrichosporon oleaginosum.
32736322	5	19	theme	carbon	606:611	arg1	sources					613:619	these carbon sources	600:619	these carbon sources	600:619	The lipid accumulation potential of these carbon sources was calculated based on a small scale metabolic model of C. oleaginosum.
32736322	9	20	theme	samples	1019:1025	arg1	composition					994:1004	The fatty acids composition	978:1004	The fatty acids composition of the lipid samples	978:1025	The fatty acids composition of the lipid samples showed similarities to vegetable oils, demonstrating the suitability in biodiesel industry.
32736322	6	21	theme	phosphate	736:744	arg1	limitation					746:755	phosphate limitation	736:755	phosphate limitation	736:755	Co-fermentation of GlcN and acetate under phosphate limitation rendered improved lipid production.
32736322	9	22	theme	lipid	1013:1017	arg1	samples					1019:1025	the lipid samples	1009:1025	the lipid samples	1009:1025	The fatty acids composition of the lipid samples showed similarities to vegetable oils, demonstrating the suitability in biodiesel industry.
32736322	5	23	theme	sources	613:619	arg1	potential					587:595	The lipid accumulation potential	564:595	The lipid accumulation potential of these carbon sources	564:619	The lipid accumulation potential of these carbon sources was calculated based on a small scale metabolic model of C. oleaginosum.
32736322	2	24	theme	different	325:333	arg1	strategies					347:356	different degradation strategies	325:356	different degradation strategies	325:356	It can be depolymerized into either N-acetylglucosamine (GlcNAc) or glucosamine (GlcN) and acetate by different degradation strategies.
32736322	0	25	theme	Efficient	0:8	arg1	conversion					10:19	Efficient conversion	0:19	Efficient conversion of chitin-derived carbon sources into microbial lipid by the oleaginous yeast Cutaneotrichosporon oleaginosum	0:129	Efficient conversion of chitin-derived carbon sources into microbial lipid by the oleaginous yeast Cutaneotrichosporon oleaginosum.
32736322	6	26	theme	acetate	722:728	arg1	Co-fermentation					694:708	Co-fermentation	694:708	Co-fermentation of GlcN and acetate under phosphate limitation	694:755	Co-fermentation of GlcN and acetate under phosphate limitation rendered improved lipid production.
32736322	0	27	theme	chitin-derived	24:37	arg1	sources					46:52	chitin-derived carbon sources	24:52	chitin-derived carbon sources	24:52	Efficient conversion of chitin-derived carbon sources into microbial lipid by the oleaginous yeast Cutaneotrichosporon oleaginosum.
32736322	9	28	from	suitability	1084:1094	arg1	industry					1109:1116	biodiesel industry	1099:1116	biodiesel industry	1099:1116	The fatty acids composition of the lipid samples showed similarities to vegetable oils, demonstrating the suitability in biodiesel industry.
32736322	8	29	used	used	945:948	arg2	GlcNAc					934:939	GlcNAc	934:939	GlcNAc	934:939	The highest lipid titer and yield of 10.1 g/L and 0.25 g/g, respectively, was reached when GlcNAc was used under phosphate limitation.
32736322	1	30	from	biomass	175:181	arg1	biosphere					212:220	the biosphere	208:220	the biosphere	208:220	Chitin represents the second most abundant biomass after lignocelluloses in the biosphere.
32736322	10	31	theme	routes	1194:1199	arg1	design					1167:1172	the design	1163:1172	the design of chitin-to-lipids routes	1163:1199	This study provides profitable guidance for the design of chitin-to-lipids routes.
32736322	10	32	theme	profitable	1139:1148	arg1	guidance					1150:1157	profitable guidance	1139:1157	profitable guidance for the design of chitin-to-lipids routes	1139:1199	This study provides profitable guidance for the design of chitin-to-lipids routes.
32736322	6	33	theme	GlcN	713:716	arg1	Co-fermentation					694:708	Co-fermentation	694:708	Co-fermentation of GlcN and acetate under phosphate limitation	694:755	Co-fermentation of GlcN and acetate under phosphate limitation rendered improved lipid production.
32736322	3	34	theme	lipid	436:440	arg1	production					442:451	lipid production	436:451	lipid production	436:451	However, these chitin-derived carbon sources have been scarcely compared for lipid production.
32736322	10	35	theme	chitin-to-lipids	1177:1192	arg1	routes					1194:1199	chitin-to-lipids routes	1177:1199	chitin-to-lipids routes	1177:1199	This study provides profitable guidance for the design of chitin-to-lipids routes.
32736322	0	36	theme	carbon	39:44	arg1	sources					46:52	chitin-derived carbon sources	24:52	chitin-derived carbon sources	24:52	Efficient conversion of chitin-derived carbon sources into microbial lipid by the oleaginous yeast Cutaneotrichosporon oleaginosum.
32736322	9	37	theme	vegetable	1050:1058	arg1	oils					1060:1063	vegetable oils	1050:1063	vegetable oils	1050:1063	The fatty acids composition of the lipid samples showed similarities to vegetable oils, demonstrating the suitability in biodiesel industry.
32736322	5	38	theme	accumulation	574:585	arg1	potential					587:595	The lipid accumulation potential	564:595	The lipid accumulation potential of these carbon sources	564:619	The lipid accumulation potential of these carbon sources was calculated based on a small scale metabolic model of C. oleaginosum.
32736322	0	39	theme	microbial	59:67	arg1	lipid					69:73	microbial lipid	59:73	microbial lipid	59:73	Efficient conversion of chitin-derived carbon sources into microbial lipid by the oleaginous yeast Cutaneotrichosporon oleaginosum.
32736322	3	40	theme	chitin-derived	374:387	arg1	sources					396:402	these chitin-derived carbon sources	368:402	these chitin-derived carbon sources	368:402	However, these chitin-derived carbon sources have been scarcely compared for lipid production.
32736322	5	41	theme	metabolic	659:667	arg1	model					669:673	a small scale metabolic model	645:673	a small scale metabolic model of C. oleaginosum	645:691	The lipid accumulation potential of these carbon sources was calculated based on a small scale metabolic model of C. oleaginosum.
32736322	1	42	theme	second	154:159	arg1	biomass					175:181	the second most abundant biomass	150:181	the second most abundant biomass after lignocelluloses in the biosphere	150:220	Chitin represents the second most abundant biomass after lignocelluloses in the biosphere.
32736322	9	43	theme	acids	988:992	arg1	composition					994:1004	The fatty acids composition	978:1004	The fatty acids composition of the lipid samples	978:1025	The fatty acids composition of the lipid samples showed similarities to vegetable oils, demonstrating the suitability in biodiesel industry.
32736322	8	44	theme	10.1 g/L	880:887	arg1	yield					871:875	yield	871:875	yield	871:875	The highest lipid titer and yield of 10.1 g/L and 0.25 g/g, respectively, was reached when GlcNAc was used under phosphate limitation.
32736322	8	44	theme	10.1 g/L	880:887	arg1	titer					861:865	The highest lipid titer	843:865	The highest lipid titer	843:865	The highest lipid titer and yield of 10.1 g/L and 0.25 g/g, respectively, was reached when GlcNAc was used under phosphate limitation.
32736322	6	45	theme	lipid	775:779	arg1	production					781:790	improved lipid production	766:790	improved lipid production	766:790	Co-fermentation of GlcN and acetate under phosphate limitation rendered improved lipid production.
32736322	1	46	theme	abundant	166:173	arg1	biomass					175:181	the second most abundant biomass	150:181	the second most abundant biomass after lignocelluloses in the biosphere	150:220	Chitin represents the second most abundant biomass after lignocelluloses in the biosphere.
32736322	9	47	theme	biodiesel	1099:1107	arg1	industry					1109:1116	biodiesel industry	1099:1116	biodiesel industry	1099:1116	The fatty acids composition of the lipid samples showed similarities to vegetable oils, demonstrating the suitability in biodiesel industry.
32736322	0	48	theme	yeast	93:97	arg1	oleaginosum					119:129	the oleaginous yeast Cutaneotrichosporon oleaginosum	78:129	the oleaginous yeast Cutaneotrichosporon oleaginosum	78:129	Efficient conversion of chitin-derived carbon sources into microbial lipid by the oleaginous yeast Cutaneotrichosporon oleaginosum.
34823087	5	0	theme	nanofibers	805:814	arg1	diameter					793:800	the diameter	789:800	the diameter of nanofibers	789:814	There is a decrease in the diameter of nanofibers by increasing the concentration of GNPs to 1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs.
34823087	6	1	theme	graphite	1067:1074	arg1	peak					1059:1062	characteristic peak	1044:1062	characteristic peak of graphite at 2θ = 26.5°	1044:1088	Transmission electron microscopy results depicted that GNPs were dispersed uniformly confirmed by the absence of characteristic peak of graphite at 2θ = 26.5°.
34823087	7	2	theme	Reflectance-Fourier	1108:1126	arg1	results					1160:1166	Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy results	1091:1166	Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy results	1091:1166	Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy results indicate the occurrence of a few interactions between GNPs and CP matrix.
34823087	2	3	theme	experimental	346:357	arg1	study					359:363	An experimental study	343:363	An experimental study	343:363	An experimental study was designed to produce nanofibers based on CP nanofibers as matrix and GNPs as reinforcement materials.
34823087	4	4	from	increase	691:698	arg1	content					708:714	GNPs content	703:714	GNPs content	703:714	The SEM results showed that the gradual increase in GNPs content led to a porous web like morphology with no bead.
34823087	1	5	theme	/Polyvinyl	259:268	arg1	PVA					279:281	PVA	279:281	PVA	279:281	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	5	theme	/Polyvinyl	259:268	arg1	GNPs-CP					285:291	GNPs-CP	285:291	GNPs-CP	285:291	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	5	theme	/Polyvinyl	259:268	arg1	Alcohol					270:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol	196:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties	196:340	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	7	6	theme	Attenuated	1091:1100	arg1	Reflectance-Fourier					1108:1126	Attenuated Total Reflectance-Fourier	1091:1126	Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy results	1091:1166	Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy results indicate the occurrence of a few interactions between GNPs and CP matrix.
34823087	1	7	with	nanofibers	294:303	arg1	properties					331:340	excellent mechanical properties	310:340	excellent mechanical properties	310:340	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	8	8	theme	Nitrogen	1242:1249	arg1	measurement					1273:1283	Nitrogen adsorption/desorption measurement	1242:1283	Nitrogen adsorption/desorption measurement	1242:1283	Nitrogen adsorption/desorption measurement demonstrated that increasing GNPs content increased the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content.
34823087	10	9	theme	1 wt	1633:1636	arg1	GNPs					1639:1642	1 wt% GNPs	1633:1642	1 wt% GNPs	1633:1642	Furthermore, the toughness of GNPs-CP nanofibers including 1 wt% GNPs significantly improved (12-fold) compared to the one for CP nanofibers.
34823087	1	10	theme	conductive	205:214	arg1	PVA					279:281	PVA	279:281	PVA	279:281	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	10	theme	conductive	205:214	arg1	GNPs-CP					285:291	GNPs-CP	285:291	GNPs-CP	285:291	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	10	theme	conductive	205:214	arg1	Alcohol					270:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol	196:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties	196:340	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	8	11	from	area	1358:1361	arg1	m2/g					1401:1404	238.377 to 386.708 m2/g	1382:1404	238.377 to 386.708 m2/g	1382:1404	Nitrogen adsorption/desorption measurement demonstrated that increasing GNPs content increased the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content.
34823087	7	12	dep	Reflectance-Fourier	1108:1126	arg1	Transform					1128:1136	Transform	1128:1136	Transform Infrared Spectroscopy	1128:1158	Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy results indicate the occurrence of a few interactions between GNPs and CP matrix.
34823087	11	13	theme	tissue	1806:1811	arg1	applications					1825:1836	tissue engineering applications	1806:1836	tissue engineering applications	1806:1836	So, the proposed composite provides a decent functionality for nanofibers as scaffolds in tissue engineering applications.
34823087	1	14	theme	nanoplatelets	225:237	arg1	PVA					279:281	PVA	279:281	PVA	279:281	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	14	theme	nanoplatelets	225:237	arg1	GNPs-CP					285:291	GNPs-CP	285:291	GNPs-CP	285:291	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	14	theme	nanoplatelets	225:237	arg1	Alcohol					270:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol	196:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties	196:340	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	11	15	from	scaffolds	1793:1801	arg1	applications					1825:1836	tissue engineering applications	1806:1836	tissue engineering applications	1806:1836	So, the proposed composite provides a decent functionality for nanofibers as scaffolds in tissue engineering applications.
34823087	4	16	theme	SEM	655:657	arg1	results					659:665	The SEM results	651:665	The SEM results	651:665	The SEM results showed that the gradual increase in GNPs content led to a porous web like morphology with no bead.
34823087	4	17	with	morphology	741:750	arg1	bead					760:763	no bead	757:763	no bead	757:763	The SEM results showed that the gradual increase in GNPs content led to a porous web like morphology with no bead.
34823087	1	18	theme	GNPs	240:243	arg1	PVA					279:281	PVA	279:281	PVA	279:281	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	18	theme	GNPs	240:243	arg1	GNPs-CP					285:291	GNPs-CP	285:291	GNPs-CP	285:291	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	18	theme	GNPs	240:243	arg1	Alcohol					270:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol	196:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties	196:340	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	9	19	theme	tensile	1511:1517	arg1	strength					1519:1526	tensile strength	1511:1526	tensile strength	1511:1526	The test results also show that the presence of GNPs considerably enhances tensile strength, elastic modulus and electrical conductivity.
34823087	8	20	theme	specific	1341:1348	arg1	area					1358:1361	the specific surface area	1337:1361	the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content	1337:1433	Nitrogen adsorption/desorption measurement demonstrated that increasing GNPs content increased the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content.
34823087	3	21	theme	GNPs	637:640	arg1	content					642:648	GNPs content	637:648	GNPs content	637:648	The microstructure and the surface morphology of the electrospun nanofibers along with their electrical and mechanical properties were examined to study the effect of GNPs content.
34823087	1	22	theme	paper	176:180	arg1	subject					160:166	The subject	156:166	The subject of this paper	156:180	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	23	theme	Alcohol	270:276	arg1	nanofibers					294:303	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers	196:303	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties	196:340	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	24	theme	mechanical	320:329	arg1	properties					331:340	excellent mechanical properties	310:340	excellent mechanical properties	310:340	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	5	25	theme	%	863:863	arg1	GNPs					865:868	1 wt% GNPs	859:868	1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs	859:928	There is a decrease in the diameter of nanofibers by increasing the concentration of GNPs to 1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs.
34823087	4	26	theme	GNPs	703:706	arg1	content					708:714	GNPs content	703:714	GNPs content	703:714	The SEM results showed that the gradual increase in GNPs content led to a porous web like morphology with no bead.
34823087	9	27	theme	electrical	1549:1558	arg1	conductivity					1560:1571	electrical conductivity	1549:1571	electrical conductivity	1549:1571	The test results also show that the presence of GNPs considerably enhances tensile strength, elastic modulus and electrical conductivity.
34823087	6	28	dep	results	964:970	arg1	depicted					972:979	depicted	972:979	results depicted that GNPs were dispersed uniformly confirmed by the absence of characteristic peak of graphite at 2θ = 26.5°	964:1088	Transmission electron microscopy results depicted that GNPs were dispersed uniformly confirmed by the absence of characteristic peak of graphite at 2θ = 26.5°.
34823087	4	29	theme	no	757:758	arg1	bead					760:763	no bead	757:763	no bead	757:763	The SEM results showed that the gradual increase in GNPs content led to a porous web like morphology with no bead.
34823087	6	30	theme	electron	944:951	arg1	microscopy					953:962	Transmission electron microscopy	931:962	Transmission electron microscopy	931:962	Transmission electron microscopy results depicted that GNPs were dispersed uniformly confirmed by the absence of characteristic peak of graphite at 2θ = 26.5°.
34823087	5	31	dep	370 ± 40 nm	875:885	arg1	to					900:901	to	900:901	to	900:901	There is a decrease in the diameter of nanofibers by increasing the concentration of GNPs to 1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs.
34823087	5	31	dep	370 ± 40 nm	875:885	arg1	144 ± 18 nm					903:913	144 ± 18 nm	903:913	144 ± 18 nm	903:913	There is a decrease in the diameter of nanofibers by increasing the concentration of GNPs to 1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs.
34823087	7	32	theme	few	1197:1199	arg1	interactions					1201:1212	a few interactions	1195:1212	a few interactions between GNPs and CP matrix	1195:1239	Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy results indicate the occurrence of a few interactions between GNPs and CP matrix.
34823087	2	33	dep	matrix	426:431	arg1	materials					459:467	materials	459:467	materials	459:467	An experimental study was designed to produce nanofibers based on CP nanofibers as matrix and GNPs as reinforcement materials.
34823087	6	34	theme	characteristic	1044:1057	arg1	peak					1059:1062	characteristic peak	1044:1062	characteristic peak of graphite at 2θ = 26.5°	1044:1088	Transmission electron microscopy results depicted that GNPs were dispersed uniformly confirmed by the absence of characteristic peak of graphite at 2θ = 26.5°.
34823087	0	35	theme	electrospun	89:99	arg1	properties					20:29	Enhanced mechanical properties	0:29	Enhanced mechanical properties	0:29	Enhanced mechanical properties and electrical conductivity of Chitosan/Polyvinyl Alcohol electrospun nanofibers by incorporation of graphene nanoplatelets.
34823087	0	35	theme	electrospun	89:99	arg1	conductivity					46:57	electrical conductivity	35:57	electrical conductivity of Chitosan/Polyvinyl Alcohol electrospun	35:99	Enhanced mechanical properties and electrical conductivity of Chitosan/Polyvinyl Alcohol electrospun nanofibers by incorporation of graphene nanoplatelets.
34823087	0	36	theme	Enhanced	0:7	arg1	properties					20:29	Enhanced mechanical properties	0:29	Enhanced mechanical properties	0:29	Enhanced mechanical properties and electrical conductivity of Chitosan/Polyvinyl Alcohol electrospun nanofibers by incorporation of graphene nanoplatelets.
34823087	5	37	from	370 ± 40 nm	875:885	arg1	GNPs					865:868	1 wt% GNPs	859:868	1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs	859:928	There is a decrease in the diameter of nanofibers by increasing the concentration of GNPs to 1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs.
34823087	10	38	theme	CP	1701:1702	arg1	nanofibers					1704:1713	CP nanofibers	1701:1713	CP nanofibers	1701:1713	Furthermore, the toughness of GNPs-CP nanofibers including 1 wt% GNPs significantly improved (12-fold) compared to the one for CP nanofibers.
34823087	5	39	theme	1 wt	919:922	arg1	GNPs					925:928	1 wt% GNPs	919:928	1 wt% GNPs	919:928	There is a decrease in the diameter of nanofibers by increasing the concentration of GNPs to 1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs.
34823087	5	40	theme	1 wt	859:862	arg1	GNPs					865:868	1 wt% GNPs	859:868	1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs	859:928	There is a decrease in the diameter of nanofibers by increasing the concentration of GNPs to 1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs.
34823087	8	41	theme	%	1420:1420	arg1	content					1427:1433	0 and 1 wt% GNPs content	1410:1433	0 and 1 wt% GNPs content	1410:1433	Nitrogen adsorption/desorption measurement demonstrated that increasing GNPs content increased the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content.
34823087	2	42	theme	CP	409:410	arg1	nanofibers					412:421	CP nanofibers	409:421	CP nanofibers as matrix and GNPs as reinforcement materials	409:467	An experimental study was designed to produce nanofibers based on CP nanofibers as matrix and GNPs as reinforcement materials.
34823087	0	43	theme	electrical	35:44	arg1	conductivity					46:57	electrical conductivity	35:57	electrical conductivity of Chitosan/Polyvinyl Alcohol electrospun	35:99	Enhanced mechanical properties and electrical conductivity of Chitosan/Polyvinyl Alcohol electrospun nanofibers by incorporation of graphene nanoplatelets.
34823087	0	44	theme	Alcohol	81:87	arg1	electrospun					89:99	Chitosan/Polyvinyl Alcohol electrospun	62:99	Chitosan/Polyvinyl Alcohol electrospun	62:99	Enhanced mechanical properties and electrical conductivity of Chitosan/Polyvinyl Alcohol electrospun nanofibers by incorporation of graphene nanoplatelets.
34823087	7	45	theme	Infrared	1138:1145	arg1	Spectroscopy					1147:1158	Infrared Spectroscopy	1138:1158	Infrared Spectroscopy	1138:1158	Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy results indicate the occurrence of a few interactions between GNPs and CP matrix.
34823087	4	46	theme	gradual	683:689	arg1	increase					691:698	the gradual increase	679:698	the gradual increase in GNPs content	679:714	The SEM results showed that the gradual increase in GNPs content led to a porous web like morphology with no bead.
34823087	11	47	theme	proposed	1724:1731	arg1	composite					1733:1741	the proposed composite	1720:1741	the proposed composite	1720:1741	So, the proposed composite provides a decent functionality for nanofibers as scaffolds in tissue engineering applications.
34823087	7	48	theme	Total	1102:1106	arg1	Reflectance-Fourier					1108:1126	Attenuated Total Reflectance-Fourier	1091:1126	Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy results	1091:1166	Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy results indicate the occurrence of a few interactions between GNPs and CP matrix.
34823087	10	49	theme	GNPs-CP	1604:1610	arg1	nanofibers					1612:1621	GNPs-CP nanofibers	1604:1621	GNPs-CP nanofibers	1604:1621	Furthermore, the toughness of GNPs-CP nanofibers including 1 wt% GNPs significantly improved (12-fold) compared to the one for CP nanofibers.
34823087	6	50	from	absence	1033:1039	arg1	2θ = 26.5°					1079:1088	2θ = 26.5°	1079:1088	2θ = 26.5°	1079:1088	Transmission electron microscopy results depicted that GNPs were dispersed uniformly confirmed by the absence of characteristic peak of graphite at 2θ = 26.5°.
34823087	8	51	from	m2/g	1401:1404	arg1	area					1358:1361	the specific surface area	1337:1361	the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content	1337:1433	Nitrogen adsorption/desorption measurement demonstrated that increasing GNPs content increased the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content.
34823087	8	51	from	m2/g	1401:1404	arg1	nanofibers					1366:1375	nanofibers	1366:1375	nanofibers from 238.377 to 386.708 m2/g	1366:1404	Nitrogen adsorption/desorption measurement demonstrated that increasing GNPs content increased the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content.
34823087	9	52	theme	test	1440:1443	arg1	results					1445:1451	The test results	1436:1451	The test results	1436:1451	The test results also show that the presence of GNPs considerably enhances tensile strength, elastic modulus and electrical conductivity.
34823087	8	53	theme	nanofibers	1366:1375	arg1	area					1358:1361	the specific surface area	1337:1361	the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content	1337:1433	Nitrogen adsorption/desorption measurement demonstrated that increasing GNPs content increased the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content.
34823087	3	54	theme	nanofibers	535:544	arg1	microstructure					474:487	The microstructure	470:487	The microstructure	470:487	The microstructure and the surface morphology of the electrospun nanofibers along with their electrical and mechanical properties were examined to study the effect of GNPs content.
34823087	3	54	theme	nanofibers	535:544	arg1	morphology					505:514	the surface morphology	493:514	the surface morphology of the electrospun nanofibers along with their electrical and mechanical properties	493:598	The microstructure and the surface morphology of the electrospun nanofibers along with their electrical and mechanical properties were examined to study the effect of GNPs content.
34823087	10	55	theme	%	1637:1637	arg1	GNPs					1639:1642	1 wt% GNPs	1633:1642	1 wt% GNPs	1633:1642	Furthermore, the toughness of GNPs-CP nanofibers including 1 wt% GNPs significantly improved (12-fold) compared to the one for CP nanofibers.
34823087	3	56	theme	mechanical	578:587	arg1	properties					589:598	their electrical and mechanical properties	557:598	their electrical and mechanical properties	557:598	The microstructure and the surface morphology of the electrospun nanofibers along with their electrical and mechanical properties were examined to study the effect of GNPs content.
34823087	5	57	theme	GNPs	851:854	arg1	concentration					834:846	the concentration	830:846	the concentration of GNPs	830:854	There is a decrease in the diameter of nanofibers by increasing the concentration of GNPs to 1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs.
34823087	6	58	theme	Transmission	931:942	arg1	microscopy					953:962	Transmission electron microscopy	931:962	Transmission electron microscopy	931:962	Transmission electron microscopy results depicted that GNPs were dispersed uniformly confirmed by the absence of characteristic peak of graphite at 2θ = 26.5°.
34823087	8	59	theme	adsorption/desorption	1251:1271	arg1	measurement					1273:1283	Nitrogen adsorption/desorption measurement	1242:1283	Nitrogen adsorption/desorption measurement	1242:1283	Nitrogen adsorption/desorption measurement demonstrated that increasing GNPs content increased the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content.
34823087	3	60	theme	electrical	563:572	arg1	properties					589:598	their electrical and mechanical properties	557:598	their electrical and mechanical properties	557:598	The microstructure and the surface morphology of the electrospun nanofibers along with their electrical and mechanical properties were examined to study the effect of GNPs content.
34823087	8	61	dep	386.708	1393:1399	arg1	to					1390:1391	to	1390:1391	to	1390:1391	Nitrogen adsorption/desorption measurement demonstrated that increasing GNPs content increased the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content.
34823087	11	62	theme	engineering	1813:1823	arg1	applications					1825:1836	tissue engineering applications	1806:1836	tissue engineering applications	1806:1836	So, the proposed composite provides a decent functionality for nanofibers as scaffolds in tissue engineering applications.
34823087	9	63	theme	GNPs	1484:1487	arg1	presence					1472:1479	the presence	1468:1479	the presence of GNPs	1468:1487	The test results also show that the presence of GNPs considerably enhances tensile strength, elastic modulus and electrical conductivity.
34823087	8	64	theme	increasing	1303:1312	arg1	content					1319:1325	increasing GNPs content	1303:1325	increasing GNPs content	1303:1325	Nitrogen adsorption/desorption measurement demonstrated that increasing GNPs content increased the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content.
34823087	5	65	theme	CP	891:892	arg1	blend					894:898	CP blend	891:898	CP blend	891:898	There is a decrease in the diameter of nanofibers by increasing the concentration of GNPs to 1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs.
34823087	7	66	theme	CP	1231:1232	arg1	matrix					1234:1239	CP matrix	1231:1239	CP matrix	1231:1239	Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy results indicate the occurrence of a few interactions between GNPs and CP matrix.
34823087	1	67	theme	Graphene	216:223	arg1	PVA					279:281	PVA	279:281	PVA	279:281	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	67	theme	Graphene	216:223	arg1	GNPs-CP					285:291	GNPs-CP	285:291	GNPs-CP	285:291	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	67	theme	Graphene	216:223	arg1	Alcohol					270:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol	196:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties	196:340	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	9	68	theme	elastic	1529:1535	arg1	modulus					1537:1543	elastic modulus	1529:1543	elastic modulus	1529:1543	The test results also show that the presence of GNPs considerably enhances tensile strength, elastic modulus and electrical conductivity.
34823087	10	69	theme	nanofibers	1612:1621	arg1	toughness					1591:1599	the toughness	1587:1599	the toughness of GNPs-CP nanofibers including 1 wt% GNPs	1587:1642	Furthermore, the toughness of GNPs-CP nanofibers including 1 wt% GNPs significantly improved (12-fold) compared to the one for CP nanofibers.
34823087	8	70	theme	surface	1350:1356	arg1	area					1358:1361	the specific surface area	1337:1361	the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content	1337:1433	Nitrogen adsorption/desorption measurement demonstrated that increasing GNPs content increased the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content.
34823087	11	71	theme	decent	1754:1759	arg1	functionality					1761:1773	a decent functionality	1752:1773	a decent functionality	1752:1773	So, the proposed composite provides a decent functionality for nanofibers as scaffolds in tissue engineering applications.
34823087	5	72	from	decrease	777:784	arg1	diameter					793:800	the diameter	789:800	the diameter of nanofibers	789:814	There is a decrease in the diameter of nanofibers by increasing the concentration of GNPs to 1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs.
34823087	7	73	theme	interactions	1201:1212	arg1	occurrence					1181:1190	the occurrence	1177:1190	the occurrence of a few interactions between GNPs and CP matrix	1177:1239	Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy results indicate the occurrence of a few interactions between GNPs and CP matrix.
34823087	5	74	theme	%	923:923	arg1	GNPs					925:928	1 wt% GNPs	919:928	1 wt% GNPs	919:928	There is a decrease in the diameter of nanofibers by increasing the concentration of GNPs to 1 wt% GNPs from 370 ± 40 nm for CP blend to 144 ± 18 nm for 1 wt% GNPs.
34823087	0	75	theme	nanoplatelets	141:153	arg1	incorporation					115:127	incorporation	115:127	incorporation of graphene nanoplatelets	115:153	Enhanced mechanical properties and electrical conductivity of Chitosan/Polyvinyl Alcohol electrospun nanofibers by incorporation of graphene nanoplatelets.
34823087	6	76	theme	peak	1059:1062	arg1	absence					1033:1039	the absence	1029:1039	the absence of characteristic peak of graphite at 2θ = 26.5°	1029:1088	Transmission electron microscopy results depicted that GNPs were dispersed uniformly confirmed by the absence of characteristic peak of graphite at 2θ = 26.5°.
34823087	6	77	dep	dispersed	996:1004	arg1	confirmed					1016:1024	confirmed	1016:1024	were dispersed uniformly confirmed by the absence of characteristic peak of graphite at 2θ = 26.5°	991:1088	Transmission electron microscopy results depicted that GNPs were dispersed uniformly confirmed by the absence of characteristic peak of graphite at 2θ = 26.5°.
34823087	0	78	theme	mechanical	9:18	arg1	properties					20:29	Enhanced mechanical properties	0:29	Enhanced mechanical properties	0:29	Enhanced mechanical properties and electrical conductivity of Chitosan/Polyvinyl Alcohol electrospun nanofibers by incorporation of graphene nanoplatelets.
34823087	4	79	theme	porous	725:730	arg1	web					732:734	a porous web	723:734	a porous web like morphology with no bead	723:763	The SEM results showed that the gradual increase in GNPs content led to a porous web like morphology with no bead.
34823087	8	80	theme	GNPs	1314:1317	arg1	content					1319:1325	increasing GNPs content	1303:1325	increasing GNPs content	1303:1325	Nitrogen adsorption/desorption measurement demonstrated that increasing GNPs content increased the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content.
34823087	3	81	theme	content	642:648	arg1	effect					627:632	the effect	623:632	the effect of GNPs content	623:648	The microstructure and the surface morphology of the electrospun nanofibers along with their electrical and mechanical properties were examined to study the effect of GNPs content.
34823087	0	82	theme	graphene	132:139	arg1	nanoplatelets					141:153	graphene nanoplatelets	132:153	graphene nanoplatelets	132:153	Enhanced mechanical properties and electrical conductivity of Chitosan/Polyvinyl Alcohol electrospun nanofibers by incorporation of graphene nanoplatelets.
34823087	0	83	theme	Chitosan/Polyvinyl	62:79	arg1	electrospun					89:99	Chitosan/Polyvinyl Alcohol electrospun	62:99	Chitosan/Polyvinyl Alcohol electrospun	62:99	Enhanced mechanical properties and electrical conductivity of Chitosan/Polyvinyl Alcohol electrospun nanofibers by incorporation of graphene nanoplatelets.
34823087	10	84	dep	improved	1658:1665	arg1	12-fold					1668:1674	12-fold	1668:1674	12-fold	1668:1674	Furthermore, the toughness of GNPs-CP nanofibers including 1 wt% GNPs significantly improved (12-fold) compared to the one for CP nanofibers.
34823087	8	85	theme	GNPs	1422:1425	arg1	content					1427:1433	0 and 1 wt% GNPs content	1410:1433	0 and 1 wt% GNPs content	1410:1433	Nitrogen adsorption/desorption measurement demonstrated that increasing GNPs content increased the specific surface area of nanofibers from 238.377 to 386.708 m2/g for 0 and 1 wt% GNPs content.
34823087	3	86	theme	surface	497:503	arg1	morphology					505:514	the surface morphology	493:514	the surface morphology of the electrospun nanofibers along with their electrical and mechanical properties	493:598	The microstructure and the surface morphology of the electrospun nanofibers along with their electrical and mechanical properties were examined to study the effect of GNPs content.
34823087	1	87	theme	excellent	310:318	arg1	properties					331:340	excellent mechanical properties	310:340	excellent mechanical properties	310:340	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	88	theme	-Chitosan	245:253	arg1	PVA					279:281	PVA	279:281	PVA	279:281	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	88	theme	-Chitosan	245:253	arg1	GNPs-CP					285:291	GNPs-CP	285:291	GNPs-CP	285:291	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	88	theme	-Chitosan	245:253	arg1	Alcohol					270:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol	196:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties	196:340	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	6	89	from	2θ = 26.5°	1079:1088	arg1	absence					1033:1039	the absence	1029:1039	the absence of characteristic peak of graphite at 2θ = 26.5°	1029:1088	Transmission electron microscopy results depicted that GNPs were dispersed uniformly confirmed by the absence of characteristic peak of graphite at 2θ = 26.5°.
34823087	6	89	from	2θ = 26.5°	1079:1088	arg1	peak					1059:1062	characteristic peak	1044:1062	characteristic peak of graphite at 2θ = 26.5°	1044:1088	Transmission electron microscopy results depicted that GNPs were dispersed uniformly confirmed by the absence of characteristic peak of graphite at 2θ = 26.5°.
34823087	3	90	theme	electrospun	523:533	arg1	nanofibers					535:544	the electrospun nanofibers	519:544	the electrospun nanofibers along with their electrical and mechanical properties	519:598	The microstructure and the surface morphology of the electrospun nanofibers along with their electrical and mechanical properties were examined to study the effect of GNPs content.
34823087	1	91	theme	CS	256:257	arg1	PVA					279:281	PVA	279:281	PVA	279:281	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	91	theme	CS	256:257	arg1	GNPs-CP					285:291	GNPs-CP	285:291	GNPs-CP	285:291	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
34823087	1	91	theme	CS	256:257	arg1	Alcohol					270:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol	196:276	a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties	196:340	The subject of this paper is to develop a highly conductive Graphene nanoplatelets (GNPs)-Chitosan (CS)/Polyvinyl Alcohol (PVA) (GNPs-CP) nanofibers with excellent mechanical properties.
33819626	4	0	theme	cell	838:841	arg1	viability					843:851	cell viability	838:851	cell viability	838:851	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	9	1	from	Changes	1383:1389	arg1	composition					1414:1424	membrane fatty-acid composition	1394:1424	membrane fatty-acid composition	1394:1424	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	9	1	from	Changes	1383:1389	arg1	content					1438:1444	ergosterol content	1427:1444	ergosterol content	1427:1444	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	9	1	from	Changes	1383:1389	arg1	production					1466:1475	exopolysaccharides production	1447:1475	exopolysaccharides production	1447:1475	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	9	1	from	Changes	1383:1389	arg1	reduction					1482:1490	reduction	1482:1490	reduction of the ROS levels	1482:1508	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	0	2	from	reduction	183:191	arg1	species					212:218	reactive oxygen species	196:218	reactive oxygen species	196:218	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	4	3	from	uptake	885:890	arg1	CCT					936:938	K. marxianus CCT 7735	923:943	K. marxianus CCT 7735	923:943	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	1	4	theme	alcohol	265:271	arg1	2-phenylethanol					221:235	2-phenylethanol	221:235	2-phenylethanol (2-PE)	221:242	2-phenylethanol (2-PE) is a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring and displays potential for application as an antifungal.
33819626	1	4	theme	alcohol	265:271	arg1	aroma					290:294	a higher aromatic alcohol with a rose-like aroma	247:294	a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring	247:350	2-phenylethanol (2-PE) is a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring and displays potential for application as an antifungal.
33819626	10	5	from	understanding	1617:1629	arg1	marxianus					1660:1668	K. marxianus	1657:1668	K. marxianus	1657:1668	Our results provided insights into a better understanding of the effects of 2-PE on K. marxianus and its adaptive responses.
33819626	0	6	from	production	168:177	arg1	species					212:218	reactive oxygen species	196:218	reactive oxygen species	196:218	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	0	7	theme	oxygen	205:210	arg1	species					212:218	reactive oxygen species	196:218	reactive oxygen species	196:218	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	6	8	theme	yeast	1118:1122	arg1	growth					1124:1129	yeast growth	1118:1129	yeast growth	1118:1129	2-PE stress impaired yeast growth, glucose uptake, fermentative metabolism, membrane permeability, and cell viability.
33819626	6	9	theme	cell	1200:1203	arg1	viability					1205:1213	cell viability	1200:1213	cell viability	1200:1213	2-PE stress impaired yeast growth, glucose uptake, fermentative metabolism, membrane permeability, and cell viability.
33819626	9	10	theme	membrane	1394:1401	arg1	composition					1414:1424	membrane fatty-acid composition	1394:1424	membrane fatty-acid composition	1394:1424	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	2	11	theme	by-products	550:560	arg1	non-use					497:503	the non-use	493:503	the non-use of toxic compounds	493:522	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	2	11	theme	by-products	550:560	arg1	generation					532:541	the generation	528:541	the generation of few by-products	528:560	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	10	12	from	marxianus	1660:1668	arg1	responses					1687:1695	its adaptive responses	1674:1695	its adaptive responses	1674:1695	Our results provided insights into a better understanding of the effects of 2-PE on K. marxianus and its adaptive responses.
33819626	10	12	from	marxianus	1660:1668	arg1	understanding					1617:1629	a better understanding	1608:1629	a better understanding of the effects of 2-PE on K. marxianus	1608:1668	Our results provided insights into a better understanding of the effects of 2-PE on K. marxianus and its adaptive responses.
33819626	3	13	theme	Kluyveromyces	563:575	arg1	strain					616:621	a thermotolerant strain	599:621	a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine	599:680	Kluyveromyces marxianus CCT 7735 is a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine; however, like other yeast species, its growth has been strongly inhibited by this alcohol.
33819626	3	13	theme	Kluyveromyces	563:575	arg1	CCT					587:589	Kluyveromyces marxianus CCT 7735	563:594	Kluyveromyces marxianus CCT 7735	563:594	Kluyveromyces marxianus CCT 7735 is a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine; however, like other yeast species, its growth has been strongly inhibited by this alcohol.
33819626	3	14	theme	thermotolerant	601:614	arg1	strain					616:621	a thermotolerant strain	599:621	a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine	599:680	Kluyveromyces marxianus CCT 7735 is a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine; however, like other yeast species, its growth has been strongly inhibited by this alcohol.
33819626	3	14	theme	thermotolerant	601:614	arg1	CCT					587:589	Kluyveromyces marxianus CCT 7735	563:594	Kluyveromyces marxianus CCT 7735	563:594	Kluyveromyces marxianus CCT 7735 is a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine; however, like other yeast species, its growth has been strongly inhibited by this alcohol.
33819626	9	15	theme	ergosterol	1427:1436	arg1	content					1438:1444	ergosterol content	1427:1444	ergosterol content	1427:1444	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	0	16	theme	exopolysaccharide	150:166	arg1	production					168:177	exopolysaccharide production	150:177	exopolysaccharide production	150:177	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	5	17	theme	stress	985:990	arg1	condition					992:1000	The stress condition	981:1000	The stress condition	981:1000	The stress condition was imposed after 4 h of cultivation by adding 3.0 g.L-1 of 2-PE in exponential growing cells.
33819626	4	18	theme	glucose	877:883	arg1	uptake					885:890	glucose uptake	877:890	glucose uptake	877:890	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	6	19	theme	fermentative	1148:1159	arg1	metabolism					1161:1170	fermentative metabolism	1148:1170	fermentative metabolism	1148:1170	2-PE stress impaired yeast growth, glucose uptake, fermentative metabolism, membrane permeability, and cell viability.
33819626	4	20	from	permeability	863:874	arg1	CCT					936:938	K. marxianus CCT 7735	923:943	K. marxianus CCT 7735	923:943	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	7	21	theme	surface	1287:1293	arg1	roughness					1295:1303	surface roughness	1287:1303	surface roughness	1287:1303	Moreover, the stress condition provoked changes in both morphology and surface roughness.
33819626	0	22	theme	2-phenylethanol	58:72	arg1	stress					74:79	2-phenylethanol stress	58:79	2-phenylethanol stress	58:79	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	5	23	theme	2-PE	1062:1065	arg1	3.0 g.L-1					1049:1057	3.0 g.L-1	1049:1057	3.0 g.L-1 of 2-PE in exponential growing cells	1049:1094	The stress condition was imposed after 4 h of cultivation by adding 3.0 g.L-1 of 2-PE in exponential growing cells.
33819626	3	24	theme	capable	623:629	arg1	strain					616:621	a thermotolerant strain	599:621	a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine	599:680	Kluyveromyces marxianus CCT 7735 is a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine; however, like other yeast species, its growth has been strongly inhibited by this alcohol.
33819626	3	24	theme	capable	623:629	arg1	CCT					587:589	Kluyveromyces marxianus CCT 7735	563:594	Kluyveromyces marxianus CCT 7735	563:594	Kluyveromyces marxianus CCT 7735 is a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine; however, like other yeast species, its growth has been strongly inhibited by this alcohol.
33819626	5	25	theme	exponential	1070:1080	arg1	cells					1090:1094	exponential growing cells	1070:1094	exponential growing cells	1070:1094	The stress condition was imposed after 4 h of cultivation by adding 3.0 g.L-1 of 2-PE in exponential growing cells.
33819626	2	26	from	yeast	450:454	arg1	alternative					474:484	an interesting alternative	459:484	an interesting alternative due to the non-use of toxic compounds and the generation of few by-products	459:560	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	2	26	from	yeast	450:454	arg1	production					426:435	Biotechnological production	409:435	Biotechnological production of 2-PE from yeast	409:454	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	4	27	from	growth	830:835	arg1	CCT					936:938	K. marxianus CCT 7735	923:943	K. marxianus CCT 7735	923:943	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	9	28	theme	ROS	1499:1501	arg1	levels					1503:1508	the ROS levels	1495:1508	the ROS levels	1495:1508	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	2	29	theme	compounds	514:522	arg1	non-use					497:503	the non-use	493:503	the non-use of toxic compounds	493:522	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	2	29	theme	compounds	514:522	arg1	generation					532:541	the generation	528:541	the generation of few by-products	528:560	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	0	30	theme	fatty-acid	106:115	arg1	composition					117:127	membrane fatty-acid composition	97:127	membrane fatty-acid composition	97:127	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	8	31	theme	oxygen	1319:1324	arg1	ROS					1335:1337	ROS	1335:1337	ROS	1335:1337	The reactive oxygen species (ROS) increased immediately on exposure to 2-PE.
33819626	8	31	theme	oxygen	1319:1324	arg1	species					1326:1332	The reactive oxygen species	1306:1332	The reactive oxygen species (ROS)	1306:1338	The reactive oxygen species (ROS) increased immediately on exposure to 2-PE.
33819626	0	32	theme	Adaptive	0:7	arg1	responses					9:17	Adaptive responses	0:17	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.	0:219	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	1	33	theme	rose-like	280:288	arg1	2-phenylethanol					221:235	2-phenylethanol	221:235	2-phenylethanol (2-PE)	221:242	2-phenylethanol (2-PE) is a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring and displays potential for application as an antifungal.
33819626	1	33	theme	rose-like	280:288	arg1	aroma					290:294	a higher aromatic alcohol with a rose-like aroma	247:294	a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring	247:350	2-phenylethanol (2-PE) is a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring and displays potential for application as an antifungal.
33819626	9	34	from	responses	1546:1554	arg1	marxianus					1562:1570	K. marxianus	1559:1570	K. marxianus	1559:1570	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	4	35	from	responses	970:978	arg1	metabolism					893:902	metabolism	893:902	metabolism	893:902	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	4	35	from	responses	970:978	arg1	growth					830:835	cell growth	825:835	cell growth	825:835	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	4	35	from	responses	970:978	arg1	permeability					863:874	membrane permeability	854:874	membrane permeability	854:874	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	4	35	from	responses	970:978	arg1	morphology					909:918	morphology	909:918	morphology	909:918	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	4	35	from	responses	970:978	arg1	viability					843:851	cell viability	838:851	cell viability	838:851	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	4	35	from	responses	970:978	arg1	uptake					885:890	glucose uptake	877:890	glucose uptake	877:890	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	2	36	theme	due	486:488	arg1	production					426:435	Biotechnological production	409:435	Biotechnological production of 2-PE from yeast	409:454	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	2	36	theme	due	486:488	arg1	alternative					474:484	an interesting alternative	459:484	an interesting alternative due to the non-use of toxic compounds and the generation of few by-products	459:560	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	10	37	theme	better	1610:1615	arg1	understanding					1617:1629	a better understanding	1608:1629	a better understanding of the effects of 2-PE on K. marxianus	1608:1668	Our results provided insights into a better understanding of the effects of 2-PE on K. marxianus and its adaptive responses.
33819626	2	38	theme	Biotechnological	409:424	arg1	alternative					474:484	an interesting alternative	459:484	an interesting alternative due to the non-use of toxic compounds and the generation of few by-products	459:560	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	2	38	theme	Biotechnological	409:424	arg1	production					426:435	Biotechnological production	409:435	Biotechnological production of 2-PE from yeast	409:454	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	0	39	theme	marxianus	36:44	arg1	CCT					46:48	Kluyveromyces marxianus CCT 7735	22:53	Kluyveromyces marxianus CCT 7735	22:53	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	9	40	theme	adaptive	1537:1544	arg1	responses					1546:1554	adaptive responses	1537:1554	adaptive responses in K. marxianus	1537:1570	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	2	41	theme	interesting	462:472	arg1	production					426:435	Biotechnological production	409:435	Biotechnological production of 2-PE from yeast	409:454	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	2	41	theme	interesting	462:472	arg1	alternative					474:484	an interesting alternative	459:484	an interesting alternative due to the non-use of toxic compounds and the generation of few by-products	459:560	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	1	42	theme	with	273:276	arg1	2-phenylethanol					221:235	2-phenylethanol	221:235	2-phenylethanol (2-PE)	221:242	2-phenylethanol (2-PE) is a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring and displays potential for application as an antifungal.
33819626	1	42	theme	with	273:276	arg1	aroma					290:294	a higher aromatic alcohol with a rose-like aroma	247:294	a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring	247:350	2-phenylethanol (2-PE) is a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring and displays potential for application as an antifungal.
33819626	3	43	theme	2-PE	649:652	arg1	titers					654:659	high 2-PE titers	644:659	high 2-PE titers	644:659	Kluyveromyces marxianus CCT 7735 is a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine; however, like other yeast species, its growth has been strongly inhibited by this alcohol.
33819626	10	44	theme	2-PE	1649:1652	arg1	effects					1638:1644	the effects	1634:1644	the effects of 2-PE on K. marxianus	1634:1668	Our results provided insights into a better understanding of the effects of 2-PE on K. marxianus and its adaptive responses.
33819626	10	45	theme	effects	1638:1644	arg1	responses					1687:1695	its adaptive responses	1674:1695	its adaptive responses	1674:1695	Our results provided insights into a better understanding of the effects of 2-PE on K. marxianus and its adaptive responses.
33819626	10	45	theme	effects	1638:1644	arg1	understanding					1617:1629	a better understanding	1608:1629	a better understanding of the effects of 2-PE on K. marxianus	1608:1668	Our results provided insights into a better understanding of the effects of 2-PE on K. marxianus and its adaptive responses.
33819626	0	46	from	content	141:147	arg1	species					212:218	reactive oxygen species	196:218	reactive oxygen species	196:218	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	0	47	theme	reactive	196:203	arg1	species					212:218	reactive oxygen species	196:218	reactive oxygen species	196:218	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	10	48	theme	K.	1657:1658	arg1	marxianus					1660:1668	K. marxianus	1657:1668	K. marxianus	1657:1668	Our results provided insights into a better understanding of the effects of 2-PE on K. marxianus and its adaptive responses.
33819626	1	49	theme	aromatic	256:263	arg1	2-phenylethanol					221:235	2-phenylethanol	221:235	2-phenylethanol (2-PE)	221:242	2-phenylethanol (2-PE) is a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring and displays potential for application as an antifungal.
33819626	1	49	theme	aromatic	256:263	arg1	aroma					290:294	a higher aromatic alcohol with a rose-like aroma	247:294	a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring	247:350	2-phenylethanol (2-PE) is a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring and displays potential for application as an antifungal.
33819626	10	50	from	effects	1638:1644	arg1	marxianus					1660:1668	K. marxianus	1657:1668	K. marxianus	1657:1668	Our results provided insights into a better understanding of the effects of 2-PE on K. marxianus and its adaptive responses.
33819626	3	51	theme	other	697:701	arg1	species					709:715	other yeast species	697:715	other yeast species	697:715	Kluyveromyces marxianus CCT 7735 is a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine; however, like other yeast species, its growth has been strongly inhibited by this alcohol.
33819626	4	52	from	morphology	909:918	arg1	CCT					936:938	K. marxianus CCT 7735	923:943	K. marxianus CCT 7735	923:943	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	10	53	theme	adaptive	1678:1685	arg1	responses					1687:1695	its adaptive responses	1674:1695	its adaptive responses	1674:1695	Our results provided insights into a better understanding of the effects of 2-PE on K. marxianus and its adaptive responses.
33819626	4	54	theme	2-PE	817:820	arg1	responses					970:978	its adaptive responses	957:978	its adaptive responses	957:978	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	4	54	theme	2-PE	817:820	arg1	effect					807:812	the effect	803:812	the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735	803:943	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	3	55	theme	marxianus	577:585	arg1	strain					616:621	a thermotolerant strain	599:621	a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine	599:680	Kluyveromyces marxianus CCT 7735 is a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine; however, like other yeast species, its growth has been strongly inhibited by this alcohol.
33819626	3	55	theme	marxianus	577:585	arg1	CCT					587:589	Kluyveromyces marxianus CCT 7735	563:594	Kluyveromyces marxianus CCT 7735	563:594	Kluyveromyces marxianus CCT 7735 is a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine; however, like other yeast species, its growth has been strongly inhibited by this alcohol.
33819626	4	56	theme	cell	825:828	arg1	growth					830:835	cell growth	825:835	cell growth	825:835	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	6	57	theme	2-PE	1097:1100	arg1	stress					1102:1107	2-PE stress	1097:1107	2-PE stress	1097:1107	2-PE stress impaired yeast growth, glucose uptake, fermentative metabolism, membrane permeability, and cell viability.
33819626	0	58	theme	ergosterol	130:139	arg1	content					141:147	ergosterol content	130:147	ergosterol content	130:147	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	9	59	theme	fatty-acid	1403:1412	arg1	composition					1414:1424	membrane fatty-acid composition	1394:1424	membrane fatty-acid composition	1394:1424	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	2	60	theme	few	546:548	arg1	by-products					550:560	few by-products	546:560	few by-products	546:560	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	0	61	from	Alterations	82:92	arg1	content					141:147	ergosterol content	130:147	ergosterol content	130:147	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	0	61	from	Alterations	82:92	arg1	production					168:177	exopolysaccharide production	150:177	exopolysaccharide production	150:177	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	0	61	from	Alterations	82:92	arg1	reduction					183:191	reduction	183:191	reduction	183:191	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	0	61	from	Alterations	82:92	arg1	composition					117:127	membrane fatty-acid composition	97:127	membrane fatty-acid composition	97:127	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	4	62	from	metabolism	893:902	arg1	CCT					936:938	K. marxianus CCT 7735	923:943	K. marxianus CCT 7735	923:943	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	6	63	theme	membrane	1173:1180	arg1	permeability					1182:1193	membrane permeability	1173:1193	membrane permeability	1173:1193	2-PE stress impaired yeast growth, glucose uptake, fermentative metabolism, membrane permeability, and cell viability.
33819626	5	64	theme	cultivation	1027:1037	arg1	4 h					1020:1022	4 h	1020:1022	4 h of cultivation	1020:1037	The stress condition was imposed after 4 h of cultivation by adding 3.0 g.L-1 of 2-PE in exponential growing cells.
33819626	4	65	from	effect	807:812	arg1	metabolism					893:902	metabolism	893:902	metabolism	893:902	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	4	65	from	effect	807:812	arg1	growth					830:835	cell growth	825:835	cell growth	825:835	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	4	65	from	effect	807:812	arg1	permeability					863:874	membrane permeability	854:874	membrane permeability	854:874	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	4	65	from	effect	807:812	arg1	morphology					909:918	morphology	909:918	morphology	909:918	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	4	65	from	effect	807:812	arg1	viability					843:851	cell viability	838:851	cell viability	838:851	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	4	65	from	effect	807:812	arg1	uptake					885:890	glucose uptake	877:890	glucose uptake	877:890	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	4	66	theme	membrane	854:861	arg1	permeability					863:874	membrane permeability	854:874	membrane permeability	854:874	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	0	67	from	composition	117:127	arg1	species					212:218	reactive oxygen species	196:218	reactive oxygen species	196:218	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	9	68	theme	exopolysaccharides	1447:1464	arg1	production					1466:1475	exopolysaccharides production	1447:1475	exopolysaccharides production	1447:1475	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	9	69	from	result	1527:1532	arg1	marxianus					1562:1570	K. marxianus	1559:1570	K. marxianus	1559:1570	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	10	70	from	responses	1687:1695	arg1	marxianus					1660:1668	K. marxianus	1657:1668	K. marxianus	1657:1668	Our results provided insights into a better understanding of the effects of 2-PE on K. marxianus and its adaptive responses.
33819626	4	71	theme	marxianus	926:934	arg1	CCT					936:938	K. marxianus CCT 7735	923:943	K. marxianus CCT 7735	923:943	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	6	72	theme	glucose	1132:1138	arg1	uptake					1140:1145	glucose uptake	1132:1145	glucose uptake	1132:1145	2-PE stress impaired yeast growth, glucose uptake, fermentative metabolism, membrane permeability, and cell viability.
33819626	4	73	from	viability	843:851	arg1	CCT					936:938	K. marxianus CCT 7735	923:943	K. marxianus CCT 7735	923:943	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	0	74	theme	membrane	97:104	arg1	composition					117:127	membrane fatty-acid composition	97:127	membrane fatty-acid composition	97:127	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	5	75	theme	growing	1082:1088	arg1	cells					1090:1094	exponential growing cells	1070:1094	exponential growing cells	1070:1094	The stress condition was imposed after 4 h of cultivation by adding 3.0 g.L-1 of 2-PE in exponential growing cells.
33819626	9	76	theme	levels	1503:1508	arg1	composition					1414:1424	membrane fatty-acid composition	1394:1424	membrane fatty-acid composition	1394:1424	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	9	76	theme	levels	1503:1508	arg1	content					1438:1444	ergosterol content	1427:1444	ergosterol content	1427:1444	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	9	76	theme	levels	1503:1508	arg1	production					1466:1475	exopolysaccharides production	1447:1475	exopolysaccharides production	1447:1475	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	9	76	theme	levels	1503:1508	arg1	reduction					1482:1490	reduction	1482:1490	reduction of the ROS levels	1482:1508	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	2	77	theme	toxic	508:512	arg1	compounds					514:522	toxic compounds	508:522	toxic compounds	508:522	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	4	78	theme	K.	923:924	arg1	CCT					936:938	K. marxianus CCT 7735	923:943	K. marxianus CCT 7735	923:943	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	5	79	from	3.0 g.L-1	1049:1057	arg1	cells					1090:1094	exponential growing cells	1070:1094	exponential growing cells	1070:1094	The stress condition was imposed after 4 h of cultivation by adding 3.0 g.L-1 of 2-PE in exponential growing cells.
33819626	9	80	from	marxianus	1562:1570	arg1	Changes					1383:1389	Changes	1383:1389	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels	1383:1508	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	9	80	from	marxianus	1562:1570	arg1	result					1527:1532	the result	1523:1532	the result of adaptive responses in K. marxianus	1523:1570	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	4	81	theme	adaptive	961:968	arg1	responses					970:978	its adaptive responses	957:978	its adaptive responses	957:978	Herein, we aimed to evaluate the effect of 2-PE on cell growth, cell viability, membrane permeability, glucose uptake, metabolism, and morphology in K. marxianus CCT 7735, as well as its adaptive responses.
33819626	8	82	theme	reactive	1310:1317	arg1	ROS					1335:1337	ROS	1335:1337	ROS	1335:1337	The reactive oxygen species (ROS) increased immediately on exposure to 2-PE.
33819626	8	82	theme	reactive	1310:1317	arg1	species					1326:1332	The reactive oxygen species	1306:1332	The reactive oxygen species (ROS)	1306:1338	The reactive oxygen species (ROS) increased immediately on exposure to 2-PE.
33819626	0	83	theme	Kluyveromyces	22:34	arg1	CCT					46:48	Kluyveromyces marxianus CCT 7735	22:53	Kluyveromyces marxianus CCT 7735	22:53	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	2	84	theme	2-PE	440:443	arg1	alternative					474:484	an interesting alternative	459:484	an interesting alternative due to the non-use of toxic compounds and the generation of few by-products	459:560	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	2	84	theme	2-PE	440:443	arg1	production					426:435	Biotechnological production	409:435	Biotechnological production of 2-PE from yeast	409:454	Biotechnological production of 2-PE from yeast is an interesting alternative due to the non-use of toxic compounds and the generation of few by-products.
33819626	0	85	theme	CCT	46:48	arg1	responses					9:17	Adaptive responses	0:17	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.	0:219	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	7	86	theme	stress	1230:1235	arg1	condition					1237:1245	the stress condition	1226:1245	the stress condition	1226:1245	Moreover, the stress condition provoked changes in both morphology and surface roughness.
33819626	3	87	theme	high	644:647	arg1	titers					654:659	high 2-PE titers	644:659	high 2-PE titers	644:659	Kluyveromyces marxianus CCT 7735 is a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine; however, like other yeast species, its growth has been strongly inhibited by this alcohol.
33819626	1	88	theme	cosmetic	308:315	arg1	industries					326:335	the cosmetic and food industries	304:335	the cosmetic and food industries	304:335	2-phenylethanol (2-PE) is a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring and displays potential for application as an antifungal.
33819626	9	89	theme	responses	1546:1554	arg1	Changes					1383:1389	Changes	1383:1389	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels	1383:1508	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	9	89	theme	responses	1546:1554	arg1	result					1527:1532	the result	1523:1532	the result of adaptive responses in K. marxianus	1523:1570	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	1	90	theme	food	321:324	arg1	industries					326:335	the cosmetic and food industries	304:335	the cosmetic and food industries	304:335	2-phenylethanol (2-PE) is a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring and displays potential for application as an antifungal.
33819626	9	91	theme	K.	1559:1560	arg1	marxianus					1562:1570	K. marxianus	1559:1570	K. marxianus	1559:1570	Changes in membrane fatty-acid composition, ergosterol content, exopolysaccharides production, and reduction of the ROS levels appear to be the result of adaptive responses in K. marxianus.
33819626	7	92	from	changes	1256:1262	arg1	morphology					1272:1281	morphology	1272:1281	morphology	1272:1281	Moreover, the stress condition provoked changes in both morphology and surface roughness.
33819626	7	92	from	changes	1256:1262	arg1	roughness					1295:1303	surface roughness	1287:1303	surface roughness	1287:1303	Moreover, the stress condition provoked changes in both morphology and surface roughness.
33819626	0	93	dep	responses	9:17	arg1	Alterations					82:92	Alterations	82:92	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.	0:219	Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species.
33819626	3	94	theme	yeast	703:707	arg1	species					709:715	other yeast species	697:715	other yeast species	697:715	Kluyveromyces marxianus CCT 7735 is a thermotolerant strain capable of producing high 2-PE titers from L-Phenylalanine; however, like other yeast species, its growth has been strongly inhibited by this alcohol.
33819626	1	95	theme	higher	249:254	arg1	2-phenylethanol					221:235	2-phenylethanol	221:235	2-phenylethanol (2-PE)	221:242	2-phenylethanol (2-PE) is a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring and displays potential for application as an antifungal.
33819626	1	95	theme	higher	249:254	arg1	aroma					290:294	a higher aromatic alcohol with a rose-like aroma	247:294	a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring	247:350	2-phenylethanol (2-PE) is a higher aromatic alcohol with a rose-like aroma used in the cosmetic and food industries as a flavoring and displays potential for application as an antifungal.
34044938	2	0	theme	nanocrystals	408:419	arg1	combination					375:385	a combination	373:385	a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles	373:503	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	1	1	theme	load-bearing	191:202	arg1	cartilage					231:239	cartilage	231:239	cartilage	231:239	Hydrogels often have poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage.
34044938	1	1	theme	load-bearing	191:202	arg1	tissues					204:210	load-bearing tissues	191:210	load-bearing tissues such as muscle and cartilage	191:239	Hydrogels often have poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage.
34044938	1	1	theme	load-bearing	191:202	arg1	muscle					220:225	muscle	220:225	muscle	220:225	Hydrogels often have poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage.
34044938	2	2	theme	polymeric	398:406	arg1	nanocrystals					408:419	natural polymeric nanocrystals	390:419	natural polymeric nanocrystals	390:419	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	2	3	theme	drug	343:346	arg1	loading					348:354	ultra-high drug loading	332:354	ultra-high drug loading	332:354	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	3	4	theme	poly	634:637	arg1	networks					671:678	poly(N-isopropylacrylamide) (PNIPAm) networks	634:678	poly(N-isopropylacrylamide) (PNIPAm) networks	634:678	The hydrogels comprise cellulose nanocrystals (CNCs) decorated with Fe3O4 nanoparticles (Fe3O4/CNCs) dispersed homogeneously in poly(N-isopropylacrylamide) (PNIPAm) networks.
34044938	5	5	theme	high	783:786	arg1	value					788:792	a high value	781:792	a high value of 10.18 g g-1	781:807	Drug loading of vancomycin (VCM) reached a high value of 10.18 g g-1 due to the dispersion of Fe3O4/CNCs and the interactions between the CNCs and the PNIPAm network.
34044938	2	6	theme	ultra-high	332:341	arg1	loading					348:354	ultra-high drug loading	332:354	ultra-high drug loading	332:354	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	2	7	theme	natural	390:396	arg1	nanocrystals					408:419	natural polymeric nanocrystals	390:419	natural polymeric nanocrystals	390:419	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	1	8	from	application	176:186	arg1	cartilage					231:239	cartilage	231:239	cartilage	231:239	Hydrogels often have poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage.
34044938	1	8	from	application	176:186	arg1	tissues					204:210	load-bearing tissues	191:210	load-bearing tissues such as muscle and cartilage	191:239	Hydrogels often have poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage.
34044938	1	8	from	application	176:186	arg1	muscle					220:225	muscle	220:225	muscle	220:225	Hydrogels often have poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage.
34044938	2	9	theme	thermo-responsive	445:461	arg1	polymer					463:469	synthetic thermo-responsive polymer	435:469	synthetic thermo-responsive polymer	435:469	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	7	10	contain	have	1059:1062	arg1	hydrogels					1049:1057	The hydrogels	1045:1057	The hydrogels	1045:1057	The hydrogels have high biocompatibility evidenced by cell proliferation tests, illustrating that these hydrogels are promising as dressings for wound closure, and wound healing.
34044938	7	10	contain	have	1059:1062	arg2	biocompatibility					1069:1084	high biocompatibility	1064:1084	high biocompatibility evidenced by cell proliferation tests	1064:1122	The hydrogels have high biocompatibility evidenced by cell proliferation tests, illustrating that these hydrogels are promising as dressings for wound closure, and wound healing.
34044938	5	11	theme	interactions	853:864	arg1	dispersion					820:829	the dispersion	816:829	the dispersion of Fe3O4/CNCs and the interactions between the CNCs and the PNIPAm network	816:904	Drug loading of vancomycin (VCM) reached a high value of 10.18 g g-1 due to the dispersion of Fe3O4/CNCs and the interactions between the CNCs and the PNIPAm network.
34044938	2	12	theme	synthetic	435:443	arg1	polymer					463:469	synthetic thermo-responsive polymer	435:469	synthetic thermo-responsive polymer	435:469	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	5	13	theme	10.18 g g-1	797:807	arg1	value					788:792	a high value	781:792	a high value of 10.18 g g-1	781:807	Drug loading of vancomycin (VCM) reached a high value of 10.18 g g-1 due to the dispersion of Fe3O4/CNCs and the interactions between the CNCs and the PNIPAm network.
34044938	0	14	theme	Cellulose	0:8	arg1	nanocrystals					10:21	Cellulose nanocrystals	0:21	Cellulose nanocrystals	0:21	Cellulose nanocrystals reinforced highly stretchable thermal-sensitive hydrogel with ultra-high drug loading.
34044938	2	15	theme	network	424:430	arg1	combination					375:385	a combination	373:385	a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles	373:503	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	2	16	theme	nanoparticles	491:503	arg1	combination					375:385	a combination	373:385	a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles	373:503	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	2	17	theme	magnetic	476:483	arg1	nanoparticles					491:503	magnetic Fe3O4 nanoparticles	476:503	magnetic Fe3O4 nanoparticles	476:503	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	2	18	theme	Fe3O4	485:489	arg1	nanoparticles					491:503	magnetic Fe3O4 nanoparticles	476:503	magnetic Fe3O4 nanoparticles	476:503	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	1	19	theme	poor	131:134	arg1	properties					147:156	poor mechanical properties	131:156	poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage	131:239	Hydrogels often have poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage.
34044938	0	20	theme	thermal-sensitive	53:69	arg1	hydrogel					71:78	highly stretchable thermal-sensitive hydrogel	34:78	highly stretchable thermal-sensitive hydrogel	34:78	Cellulose nanocrystals reinforced highly stretchable thermal-sensitive hydrogel with ultra-high drug loading.
34044938	7	21	theme	proliferation	1104:1116	arg1	tests					1118:1122	cell proliferation tests	1099:1122	cell proliferation tests	1099:1122	The hydrogels have high biocompatibility evidenced by cell proliferation tests, illustrating that these hydrogels are promising as dressings for wound closure, and wound healing.
34044938	4	22	theme	%	737:737	arg1	extensibility					716:728	an extensibility	713:728	an extensibility of 2200%	713:737	The composite hydrogels exhibit an extensibility of 2200%.
34044938	7	23	theme	wound	1190:1194	arg1	closure					1196:1202	wound closure	1190:1202	wound closure	1190:1202	The hydrogels have high biocompatibility evidenced by cell proliferation tests, illustrating that these hydrogels are promising as dressings for wound closure, and wound healing.
34044938	0	24	theme	stretchable	41:51	arg1	hydrogel					71:78	highly stretchable thermal-sensitive hydrogel	34:78	highly stretchable thermal-sensitive hydrogel	34:78	Cellulose nanocrystals reinforced highly stretchable thermal-sensitive hydrogel with ultra-high drug loading.
34044938	7	25	theme	wound	1209:1213	arg1	healing					1215:1221	wound healing	1209:1221	wound healing	1209:1221	The hydrogels have high biocompatibility evidenced by cell proliferation tests, illustrating that these hydrogels are promising as dressings for wound closure, and wound healing.
34044938	2	26	theme	polymer	463:469	arg1	nanocrystals					408:419	natural polymeric nanocrystals	390:419	natural polymeric nanocrystals	390:419	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	2	26	theme	polymer	463:469	arg1	network					424:430	a network	422:430	a network of synthetic thermo-responsive polymer	422:469	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	2	26	theme	polymer	463:469	arg1	nanoparticles					491:503	magnetic Fe3O4 nanoparticles	476:503	magnetic Fe3O4 nanoparticles	476:503	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	5	27	theme	Fe3O4/CNCs	834:843	arg1	dispersion					820:829	the dispersion	816:829	the dispersion of Fe3O4/CNCs and the interactions between the CNCs and the PNIPAm network	816:904	Drug loading of vancomycin (VCM) reached a high value of 10.18 g g-1 due to the dispersion of Fe3O4/CNCs and the interactions between the CNCs and the PNIPAm network.
34044938	1	28	contain	have	126:129	arg2	properties					147:156	poor mechanical properties	131:156	poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage	131:239	Hydrogels often have poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage.
34044938	1	28	contain	have	126:129	arg1	Hydrogels					110:118	Hydrogels	110:118	Hydrogels	110:118	Hydrogels often have poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage.
34044938	5	29	theme	Drug	740:743	arg1	loading					745:751	Drug loading	740:751	Drug loading of vancomycin (VCM)	740:771	Drug loading of vancomycin (VCM) reached a high value of 10.18 g g-1 due to the dispersion of Fe3O4/CNCs and the interactions between the CNCs and the PNIPAm network.
34044938	7	30	theme	high	1064:1067	arg1	biocompatibility					1069:1084	high biocompatibility	1064:1084	high biocompatibility evidenced by cell proliferation tests	1064:1122	The hydrogels have high biocompatibility evidenced by cell proliferation tests, illustrating that these hydrogels are promising as dressings for wound closure, and wound healing.
34044938	1	31	theme	mechanical	136:145	arg1	properties					147:156	poor mechanical properties	131:156	poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage	131:239	Hydrogels often have poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage.
34044938	7	32	theme	cell	1099:1102	arg1	tests					1118:1122	cell proliferation tests	1099:1122	cell proliferation tests	1099:1122	The hydrogels have high biocompatibility evidenced by cell proliferation tests, illustrating that these hydrogels are promising as dressings for wound closure, and wound healing.
34044938	3	33	theme	Fe3O4	574:578	arg1	Fe3O4/CNCs					595:604	Fe3O4/CNCs	595:604	Fe3O4/CNCs	595:604	The hydrogels comprise cellulose nanocrystals (CNCs) decorated with Fe3O4 nanoparticles (Fe3O4/CNCs) dispersed homogeneously in poly(N-isopropylacrylamide) (PNIPAm) networks.
34044938	3	33	theme	Fe3O4	574:578	arg1	nanoparticles					580:592	Fe3O4 nanoparticles	574:592	Fe3O4 nanoparticles (Fe3O4/CNCs) dispersed homogeneously in poly(N-isopropylacrylamide) (PNIPAm) networks	574:678	The hydrogels comprise cellulose nanocrystals (CNCs) decorated with Fe3O4 nanoparticles (Fe3O4/CNCs) dispersed homogeneously in poly(N-isopropylacrylamide) (PNIPAm) networks.
34044938	2	34	theme	thermal-sensitive	300:316	arg1	hydrogel					318:325	a near-infrared light-triggered stretchable thermal-sensitive hydrogel	256:325	a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading	256:354	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	5	35	theme	vancomycin	756:765	arg1	loading					745:751	Drug loading	740:751	Drug loading of vancomycin (VCM)	740:771	Drug loading of vancomycin (VCM) reached a high value of 10.18 g g-1 due to the dispersion of Fe3O4/CNCs and the interactions between the CNCs and the PNIPAm network.
34044938	2	36	theme	stretchable	288:298	arg1	hydrogel					318:325	a near-infrared light-triggered stretchable thermal-sensitive hydrogel	256:325	a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading	256:354	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	2	37	with	hydrogel	318:325	arg1	loading					348:354	ultra-high drug loading	332:354	ultra-high drug loading	332:354	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	0	38	theme	drug	96:99	arg1	loading					101:107	ultra-high drug loading	85:107	ultra-high drug loading	85:107	Cellulose nanocrystals reinforced highly stretchable thermal-sensitive hydrogel with ultra-high drug loading.
34044938	5	39	theme	PNIPAm	891:896	arg1	network					898:904	the PNIPAm network	887:904	the PNIPAm network	887:904	Drug loading of vancomycin (VCM) reached a high value of 10.18 g g-1 due to the dispersion of Fe3O4/CNCs and the interactions between the CNCs and the PNIPAm network.
34044938	2	40	theme	light-triggered	272:286	arg1	hydrogel					318:325	a near-infrared light-triggered stretchable thermal-sensitive hydrogel	256:325	a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading	256:354	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
34044938	3	41	theme	cellulose	529:537	arg1	CNCs					553:556	CNCs	553:556	CNCs	553:556	The hydrogels comprise cellulose nanocrystals (CNCs) decorated with Fe3O4 nanoparticles (Fe3O4/CNCs) dispersed homogeneously in poly(N-isopropylacrylamide) (PNIPAm) networks.
34044938	3	41	theme	cellulose	529:537	arg1	nanocrystals					539:550	cellulose nanocrystals	529:550	cellulose nanocrystals (CNCs) decorated with Fe3O4 nanoparticles (Fe3O4/CNCs) dispersed homogeneously in poly(N-isopropylacrylamide) (PNIPAm) networks	529:678	The hydrogels comprise cellulose nanocrystals (CNCs) decorated with Fe3O4 nanoparticles (Fe3O4/CNCs) dispersed homogeneously in poly(N-isopropylacrylamide) (PNIPAm) networks.
34044938	4	42	theme	composite	685:693	arg1	hydrogels					695:703	The composite hydrogels	681:703	The composite hydrogels	681:703	The composite hydrogels exhibit an extensibility of 2200%.
34044938	0	43	theme	ultra-high	85:94	arg1	loading					101:107	ultra-high drug loading	85:107	ultra-high drug loading	85:107	Cellulose nanocrystals reinforced highly stretchable thermal-sensitive hydrogel with ultra-high drug loading.
34044938	2	44	theme	near-infrared	258:270	arg1	hydrogel					318:325	a near-infrared light-triggered stretchable thermal-sensitive hydrogel	256:325	a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading	256:354	In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals, a network of synthetic thermo-responsive polymer, and magnetic Fe3O4 nanoparticles.
33848549	5	0	theme	variables	630:638	arg1	study					608:612	study	608:612	study of the reaction variables, including basicity, dye concentration and catalyst loading	608:698	Furthermore, study of the reaction variables, including basicity, dye concentration and catalyst loading showed that the highest catalytic activity was achieved at basic condition.
33848549	7	1	theme	kinetic	965:971	arg1	studies					973:979	kinetic studies	965:979	kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF	965:1061	To disclose the merits of the composite compared to its individual components, kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF have been performed.
33848549	5	2	theme	basic	759:763	arg1	condition					765:773	basic condition	759:773	basic condition	759:773	Furthermore, study of the reaction variables, including basicity, dye concentration and catalyst loading showed that the highest catalytic activity was achieved at basic condition.
33848549	9	3	theme	created	1245:1251	arg1	species					1287:1293	the most effective species	1268:1293	the most effective species in the process of photocatalytic degradation of MB	1268:1344	The study of the mechanism of the reaction using scavengers confirmed that the created holes (h+) are the most effective species in the process of photocatalytic degradation of MB.
33848549	9	3	theme	created	1245:1251	arg1	h+					1260:1261	h+	1260:1261	h+	1260:1261	The study of the mechanism of the reaction using scavengers confirmed that the created holes (h+) are the most effective species in the process of photocatalytic degradation of MB.
33848549	9	3	theme	created	1245:1251	arg1	holes					1253:1257	the created holes	1241:1257	the created holes (h+)	1241:1262	The study of the mechanism of the reaction using scavengers confirmed that the created holes (h+) are the most effective species in the process of photocatalytic degradation of MB.
33848549	7	4	theme	individual	942:951	arg1	components					953:962	its individual components	938:962	its individual components	938:962	To disclose the merits of the composite compared to its individual components, kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF have been performed.
33848549	7	5	theme	chitin	1048:1053	arg1	presence					1021:1028	the presence	1017:1028	the presence of the composite, chitin and MOF	1017:1061	To disclose the merits of the composite compared to its individual components, kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF have been performed.
33848549	0	6	theme	dyes	85:88	arg1	photodegradation					57:72	photodegradation	57:72	photodegradation of organic dyes	57:88	Composite of MOF and chitin as an efficient catalyst for photodegradation of organic dyes.
33848549	4	7	theme	light	576:580	arg1	irradiation					582:592	visible light irradiation	568:592	visible light irradiation	568:592	The results indicated superior catalytic activity under visible light irradiation.
33848549	0	8	theme	organic	77:83	arg1	dyes					85:88	organic dyes	77:88	organic dyes	77:88	Composite of MOF and chitin as an efficient catalyst for photodegradation of organic dyes.
33848549	2	9	theme	2-aminoterephthalic	240:258	arg1	acid					260:263	2-aminoterephthalic acid	240:263	2-aminoterephthalic acid	240:263	To this purpose, MOF was synthesized by using 2-aminoterephthalic acid and iron (III) chloride hexahydrate and then reacted with Cl-functionalized chitin.
33848549	3	10	used	utilized	395:402	arg2	catalyst					409:416	a catalyst	407:416	a catalyst for degradation of methylene blue both in dark condition and under visible light irradiation	407:509	The resulting composite was characterized and utilized as a catalyst for degradation of methylene blue both in dark condition and under visible light irradiation.
33848549	3	10	used	utilized	395:402	arg2	composite					363:371	The resulting composite	349:371	The resulting composite	349:371	The resulting composite was characterized and utilized as a catalyst for degradation of methylene blue both in dark condition and under visible light irradiation.
33848549	4	11	theme	visible	568:574	arg1	irradiation					582:592	visible light irradiation	568:592	visible light irradiation	568:592	The results indicated superior catalytic activity under visible light irradiation.
33848549	5	12	theme	catalytic	724:732	arg1	activity					734:741	the highest catalytic activity	712:741	the highest catalytic activity	712:741	Furthermore, study of the reaction variables, including basicity, dye concentration and catalyst loading showed that the highest catalytic activity was achieved at basic condition.
33848549	10	13	theme	dyes	1427:1430	arg1	degradation					1406:1416	degradation	1406:1416	degradation of other dyes	1406:1430	Notably, the catalyst was recyclable and could be used for degradation of other dyes.
33848549	3	14	theme	light	493:497	arg1	irradiation					499:509	visible light irradiation	485:509	visible light irradiation	485:509	The resulting composite was characterized and utilized as a catalyst for degradation of methylene blue both in dark condition and under visible light irradiation.
33848549	9	15	theme	effective	1277:1285	arg1	holes					1253:1257	the created holes	1241:1257	the created holes (h+)	1241:1262	The study of the mechanism of the reaction using scavengers confirmed that the created holes (h+) are the most effective species in the process of photocatalytic degradation of MB.
33848549	9	15	theme	effective	1277:1285	arg1	species					1287:1293	the most effective species	1268:1293	the most effective species in the process of photocatalytic degradation of MB	1268:1344	The study of the mechanism of the reaction using scavengers confirmed that the created holes (h+) are the most effective species in the process of photocatalytic degradation of MB.
33848549	6	16	theme	catalytic	866:874	arg1	activity					876:883	the catalytic activity	862:883	the catalytic activity	862:883	It was also found that both initial dye concentration and catalyst loading can affect the catalytic activity.
33848549	10	17	theme	other	1421:1425	arg1	dyes					1427:1430	other dyes	1421:1430	other dyes	1421:1430	Notably, the catalyst was recyclable and could be used for degradation of other dyes.
33848549	7	18	theme	composite	916:924	arg1	merits					902:907	the merits	898:907	the merits of the composite	898:924	To disclose the merits of the composite compared to its individual components, kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF have been performed.
33848549	7	19	from	presence	1021:1028	arg1	studies					973:979	kinetic studies	965:979	kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF	965:1061	To disclose the merits of the composite compared to its individual components, kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF have been performed.
33848549	10	20	used	used	1397:1400	arg2	recyclable					1373:1382	recyclable	1373:1382	recyclable	1373:1382	Notably, the catalyst was recyclable and could be used for degradation of other dyes.
33848549	10	20	used	used	1397:1400	arg2	catalyst					1360:1367	the catalyst	1356:1367	the catalyst	1356:1367	Notably, the catalyst was recyclable and could be used for degradation of other dyes.
33848549	7	21	theme	MOF	1059:1061	arg1	presence					1021:1028	the presence	1017:1028	the presence of the composite, chitin and MOF	1017:1061	To disclose the merits of the composite compared to its individual components, kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF have been performed.
33848549	9	22	theme	mechanism	1183:1191	arg1	study					1170:1174	The study	1166:1174	The study of the mechanism of the reaction using scavengers	1166:1224	The study of the mechanism of the reaction using scavengers confirmed that the created holes (h+) are the most effective species in the process of photocatalytic degradation of MB.
33848549	7	23	from	studies	973:979	arg1	presence					1021:1028	the presence	1017:1028	the presence of the composite, chitin and MOF	1017:1061	To disclose the merits of the composite compared to its individual components, kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF have been performed.
33848549	3	24	theme	resulting	353:361	arg1	catalyst					409:416	a catalyst	407:416	a catalyst for degradation of methylene blue both in dark condition and under visible light irradiation	407:509	The resulting composite was characterized and utilized as a catalyst for degradation of methylene blue both in dark condition and under visible light irradiation.
33848549	3	24	theme	resulting	353:361	arg1	composite					363:371	The resulting composite	349:371	The resulting composite	349:371	The resulting composite was characterized and utilized as a catalyst for degradation of methylene blue both in dark condition and under visible light irradiation.
33848549	5	25	theme	reaction	621:628	arg1	concentration					665:677	dye concentration	661:677	dye concentration	661:677	Furthermore, study of the reaction variables, including basicity, dye concentration and catalyst loading showed that the highest catalytic activity was achieved at basic condition.
33848549	5	25	theme	reaction	621:628	arg1	loading					692:698	catalyst loading	683:698	catalyst loading	683:698	Furthermore, study of the reaction variables, including basicity, dye concentration and catalyst loading showed that the highest catalytic activity was achieved at basic condition.
33848549	5	25	theme	reaction	621:628	arg1	variables					630:638	the reaction variables	617:638	the reaction variables	617:638	Furthermore, study of the reaction variables, including basicity, dye concentration and catalyst loading showed that the highest catalytic activity was achieved at basic condition.
33848549	5	25	theme	reaction	621:628	arg1	basicity					651:658	basicity	651:658	basicity	651:658	Furthermore, study of the reaction variables, including basicity, dye concentration and catalyst loading showed that the highest catalytic activity was achieved at basic condition.
33848549	5	26	theme	catalyst	683:690	arg1	loading					692:698	catalyst loading	683:698	catalyst loading	683:698	Furthermore, study of the reaction variables, including basicity, dye concentration and catalyst loading showed that the highest catalytic activity was achieved at basic condition.
33848549	2	27	theme	iron	269:272	arg1	hexahydrate					289:299	iron (III) chloride hexahydrate	269:299	iron (III) chloride hexahydrate	269:299	To this purpose, MOF was synthesized by using 2-aminoterephthalic acid and iron (III) chloride hexahydrate and then reacted with Cl-functionalized chitin.
33848549	1	28	theme	natural	158:164	arg1	MOF					138:140	MOF	138:140	MOF	138:140	A novel composite has been fabricated by using MOF and chitin as a natural and biocompatible compound.
33848549	1	28	theme	natural	158:164	arg1	chitin					146:151	chitin	146:151	chitin	146:151	A novel composite has been fabricated by using MOF and chitin as a natural and biocompatible compound.
33848549	1	28	theme	natural	158:164	arg1	compound					184:191	a natural and biocompatible compound	156:191	a natural and biocompatible compound	156:191	A novel composite has been fabricated by using MOF and chitin as a natural and biocompatible compound.
33848549	0	29	theme	MOF	13:15	arg1	MOF					13:15	MOF	13:15	MOF	13:15	Composite of MOF and chitin as an efficient catalyst for photodegradation of organic dyes.
33848549	0	29	theme	MOF	13:15	arg1	Composite					0:8	Composite	0:8	Composite of MOF and chitin as an efficient catalyst for photodegradation of organic dyes.	0:89	Composite of MOF and chitin as an efficient catalyst for photodegradation of organic dyes.
33848549	0	29	theme	MOF	13:15	arg1	chitin					21:26	chitin	21:26	chitin	21:26	Composite of MOF and chitin as an efficient catalyst for photodegradation of organic dyes.
33848549	4	30	theme	catalytic	543:551	arg1	activity					553:560	superior catalytic activity	534:560	superior catalytic activity	534:560	The results indicated superior catalytic activity under visible light irradiation.
33848549	9	31	theme	reaction	1200:1207	arg1	mechanism					1183:1191	the mechanism	1179:1191	the mechanism of the reaction using scavengers	1179:1224	The study of the mechanism of the reaction using scavengers confirmed that the created holes (h+) are the most effective species in the process of photocatalytic degradation of MB.
33848549	3	32	theme	methylene	437:445	arg1	degradation					422:432	degradation	422:432	degradation of methylene blue both in dark condition and under visible light irradiation	422:509	The resulting composite was characterized and utilized as a catalyst for degradation of methylene blue both in dark condition and under visible light irradiation.
33848549	4	33	theme	superior	534:541	arg1	activity					553:560	superior catalytic activity	534:560	superior catalytic activity	534:560	The results indicated superior catalytic activity under visible light irradiation.
33848549	7	34	theme	composite	1037:1045	arg1	presence					1021:1028	the presence	1017:1028	the presence of the composite, chitin and MOF	1017:1061	To disclose the merits of the composite compared to its individual components, kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF have been performed.
33848549	7	35	from	process	1006:1012	arg1	presence					1021:1028	the presence	1017:1028	the presence of the composite, chitin and MOF	1017:1061	To disclose the merits of the composite compared to its individual components, kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF have been performed.
33848549	1	36	theme	biocompatible	170:182	arg1	MOF					138:140	MOF	138:140	MOF	138:140	A novel composite has been fabricated by using MOF and chitin as a natural and biocompatible compound.
33848549	1	36	theme	biocompatible	170:182	arg1	chitin					146:151	chitin	146:151	chitin	146:151	A novel composite has been fabricated by using MOF and chitin as a natural and biocompatible compound.
33848549	1	36	theme	biocompatible	170:182	arg1	compound					184:191	a natural and biocompatible compound	156:191	a natural and biocompatible compound	156:191	A novel composite has been fabricated by using MOF and chitin as a natural and biocompatible compound.
33848549	0	37	theme	chitin	21:26	arg1	MOF					13:15	MOF	13:15	MOF	13:15	Composite of MOF and chitin as an efficient catalyst for photodegradation of organic dyes.
33848549	0	37	theme	chitin	21:26	arg1	Composite					0:8	Composite	0:8	Composite of MOF and chitin as an efficient catalyst for photodegradation of organic dyes.	0:89	Composite of MOF and chitin as an efficient catalyst for photodegradation of organic dyes.
33848549	0	37	theme	chitin	21:26	arg1	chitin					21:26	chitin	21:26	chitin	21:26	Composite of MOF and chitin as an efficient catalyst for photodegradation of organic dyes.
33848549	9	38	theme	photocatalytic	1313:1326	arg1	degradation					1328:1338	photocatalytic degradation	1313:1338	photocatalytic degradation of MB	1313:1344	The study of the mechanism of the reaction using scavengers confirmed that the created holes (h+) are the most effective species in the process of photocatalytic degradation of MB.
33848549	7	39	theme	process	1006:1012	arg1	studies					973:979	kinetic studies	965:979	kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF	965:1061	To disclose the merits of the composite compared to its individual components, kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF have been performed.
33848549	0	40	theme	efficient	34:42	arg1	catalyst					44:51	an efficient catalyst	31:51	an efficient catalyst for photodegradation of organic dyes	31:88	Composite of MOF and chitin as an efficient catalyst for photodegradation of organic dyes.
33848549	9	41	theme	degradation	1328:1338	arg1	process					1302:1308	the process	1298:1308	the process of photocatalytic degradation of MB	1298:1344	The study of the mechanism of the reaction using scavengers confirmed that the created holes (h+) are the most effective species in the process of photocatalytic degradation of MB.
33848549	6	42	theme	catalyst	834:841	arg1	loading					843:849	catalyst loading	834:849	catalyst loading	834:849	It was also found that both initial dye concentration and catalyst loading can affect the catalytic activity.
33848549	3	43	from	degradation	422:432	arg1	condition					465:473	dark condition	460:473	dark condition	460:473	The resulting composite was characterized and utilized as a catalyst for degradation of methylene blue both in dark condition and under visible light irradiation.
33848549	1	44	theme	novel	93:97	arg1	composite					99:107	A novel composite	91:107	A novel composite	91:107	A novel composite has been fabricated by using MOF and chitin as a natural and biocompatible compound.
33848549	5	45	theme	dye	661:663	arg1	concentration					665:677	dye concentration	661:677	dye concentration	661:677	Furthermore, study of the reaction variables, including basicity, dye concentration and catalyst loading showed that the highest catalytic activity was achieved at basic condition.
33848549	3	46	theme	dark	460:463	arg1	condition					465:473	dark condition	460:473	dark condition	460:473	The resulting composite was characterized and utilized as a catalyst for degradation of methylene blue both in dark condition and under visible light irradiation.
33848549	9	47	theme	MB	1343:1344	arg1	degradation					1328:1338	photocatalytic degradation	1313:1338	photocatalytic degradation of MB	1313:1344	The study of the mechanism of the reaction using scavengers confirmed that the created holes (h+) are the most effective species in the process of photocatalytic degradation of MB.
33848549	7	48	theme	photo-degradation	988:1004	arg1	process					1006:1012	the photo-degradation process	984:1012	the photo-degradation process in the presence of the composite, chitin and MOF	984:1061	To disclose the merits of the composite compared to its individual components, kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF have been performed.
33848549	2	49	theme	chloride	280:287	arg1	hexahydrate					289:299	iron (III) chloride hexahydrate	269:299	iron (III) chloride hexahydrate	269:299	To this purpose, MOF was synthesized by using 2-aminoterephthalic acid and iron (III) chloride hexahydrate and then reacted with Cl-functionalized chitin.
33848549	6	50	theme	dye	812:814	arg1	concentration					816:828	initial dye concentration	804:828	initial dye concentration	804:828	It was also found that both initial dye concentration and catalyst loading can affect the catalytic activity.
33848549	9	51	from	species	1287:1293	arg1	process					1302:1308	the process	1298:1308	the process of photocatalytic degradation of MB	1298:1344	The study of the mechanism of the reaction using scavengers confirmed that the created holes (h+) are the most effective species in the process of photocatalytic degradation of MB.
33848549	3	52	theme	blue	447:450	arg1	methylene					437:445	methylene blue	437:450	methylene blue	437:450	The resulting composite was characterized and utilized as a catalyst for degradation of methylene blue both in dark condition and under visible light irradiation.
33848549	7	53	dep	composite	1037:1045	arg1	the					1033:1035	the	1033:1035	the	1033:1035	To disclose the merits of the composite compared to its individual components, kinetic studies of the photo-degradation process in the presence of the composite, chitin and MOF have been performed.
33848549	6	54	theme	initial	804:810	arg1	concentration					816:828	initial dye concentration	804:828	initial dye concentration	804:828	It was also found that both initial dye concentration and catalyst loading can affect the catalytic activity.
33848549	2	55	theme	Cl-functionalized	323:339	arg1	chitin					341:346	Cl-functionalized chitin	323:346	Cl-functionalized chitin	323:346	To this purpose, MOF was synthesized by using 2-aminoterephthalic acid and iron (III) chloride hexahydrate and then reacted with Cl-functionalized chitin.
33848549	8	56	theme	superior	1106:1113	arg1	activity					1115:1122	superior activity	1106:1122	superior activity	1106:1122	The results confirmed superior activity the composite compared to its components.
33848549	3	57	theme	visible	485:491	arg1	irradiation					499:509	visible light irradiation	485:509	visible light irradiation	485:509	The resulting composite was characterized and utilized as a catalyst for degradation of methylene blue both in dark condition and under visible light irradiation.
33848549	5	58	theme	highest	716:722	arg1	activity					734:741	the highest catalytic activity	712:741	the highest catalytic activity	712:741	Furthermore, study of the reaction variables, including basicity, dye concentration and catalyst loading showed that the highest catalytic activity was achieved at basic condition.
33865587	16	0	theme	night	1910:1914	arg1	milk					1916:1919	night milk	1910:1919	night milk	1910:1919	However, the other 33 metabolites analyzed, including carbohydrates, lipids, AA, and aromatic compounds, showed lower concentrations in day milk than in night milk.
33865587	3	1	dep	milk	360:363	arg1	the					352:354	the	352:354	the	352:354	The aim of the present study was to investigate the difference in composition between the day milk and night milk of dairy cows.
33865587	18	2	from	changes	2035:2041	arg1	rhythm					2060:2065	the circadian rhythm	2046:2065	the circadian rhythm	2046:2065	Notable changes in the circadian rhythm also altered milk composition.
33865587	8	3	theme	ELISA	846:850	arg1	kits					852:855	ELISA kits	846:855	ELISA kits	846:855	An automatic biochemical analyzer and ELISA kits were used to determine biochemical indicators, as well as antioxidant and immune parameters in the milk.
33865587	6	4	theme	macronutrient	670:682	arg1	content					684:690	macronutrient content	670:690	macronutrient content of milk	670:698	Mid-infrared spectroscopy was used to analyze macronutrient content of milk.
33865587	19	5	theme	day	2180:2182	arg1	milk					2184:2187	day milk	2180:2187	day milk	2180:2187	These results provide evidence to support the strategic use and classification of day milk and night milk.
33865587	7	6	used	used	734:737	arg2	lipidomics					718:727	lipidomics	718:727	lipidomics	718:727	Metabolomics and lipidomics were used to detect and analyze small molecules and fatty acids, respectively.
33865587	7	6	used	used	734:737	arg2	Metabolomics					701:712	Metabolomics	701:712	Metabolomics	701:712	Metabolomics and lipidomics were used to detect and analyze small molecules and fatty acids, respectively.
33865587	8	7	used	used	862:865	arg2	analyzer					833:840	An automatic biochemical analyzer	808:840	An automatic biochemical analyzer	808:840	An automatic biochemical analyzer and ELISA kits were used to determine biochemical indicators, as well as antioxidant and immune parameters in the milk.
33865587	8	7	used	used	862:865	arg2	kits					852:855	ELISA kits	846:855	ELISA kits	846:855	An automatic biochemical analyzer and ELISA kits were used to determine biochemical indicators, as well as antioxidant and immune parameters in the milk.
33865587	9	8	theme	day	1046:1048	arg1	milk					1050:1053	day milk	1046:1053	day milk	1046:1053	Though milk fat, protein, lactose, and total milk solids were not different between day milk and night milk, small molecules, metabolites and lipids, and hormones and cytokines differed between day milk and night milk.
33865587	5	9	theme	night	542:546	arg1	"					552:552	"night milk"	541:552	"night milk"	541:552	Milk samples were collected at 0500 h ("night milk") and 1500 h ("day milk") and analyzed to determine their composition.
33865587	5	9	theme	night	542:546	arg1	h					538:538	0500 h	533:538	0500 h ("night milk")	533:553	Milk samples were collected at 0500 h ("night milk") and 1500 h ("day milk") and analyzed to determine their composition.
33865587	19	10	theme	milk	2199:2202	arg1	classification					2162:2175	classification	2162:2175	classification	2162:2175	These results provide evidence to support the strategic use and classification of day milk and night milk.
33865587	19	10	theme	milk	2199:2202	arg1	use					2154:2156	use	2154:2156	use	2154:2156	These results provide evidence to support the strategic use and classification of day milk and night milk.
33865587	8	11	theme	biochemical	880:890	arg1	indicators					892:901	biochemical indicators	880:901	biochemical indicators	880:901	An automatic biochemical analyzer and ELISA kits were used to determine biochemical indicators, as well as antioxidant and immune parameters in the milk.
33865587	12	12	from	melatonin	1441:1449	arg1	rich					1433:1436	rich	1433:1436	rich	1433:1436	Additionally, night milk was naturally rich in melatonin.
33865587	5	13	theme	milk	572:575	arg1	"					576:576	"day milk"	567:576	"day milk"	567:576	Milk samples were collected at 0500 h ("night milk") and 1500 h ("day milk") and analyzed to determine their composition.
33865587	5	13	theme	milk	572:575	arg1	h					564:564	1500 h	559:564	1500 h ("day milk")	559:577	Milk samples were collected at 0500 h ("night milk") and 1500 h ("day milk") and analyzed to determine their composition.
33865587	9	14	theme	small	1071:1075	arg1	molecules					1077:1085	small molecules	1071:1085	small molecules	1071:1085	Though milk fat, protein, lactose, and total milk solids were not different between day milk and night milk, small molecules, metabolites and lipids, and hormones and cytokines differed between day milk and night milk.
33865587	14	15	theme	day	1626:1628	arg1	milk					1630:1633	day milk	1626:1633	day milk	1626:1633	Metabolomics analyses identified 36 different metabolites between day milk and night milk.
33865587	15	16	theme	cis-aconitate	1700:1712	arg1	concentrations					1658:1671	Higher concentrations	1651:1671	Higher concentrations of N-acetyl-d-glucosamine, cis-aconitate, and d-sorbitol	1651:1728	Higher concentrations of N-acetyl-d-glucosamine, cis-aconitate, and d-sorbitol were observed in day milk.
33865587	3	17	theme	present	281:287	arg1	study					289:293	the present study	277:293	the present study	277:293	The aim of the present study was to investigate the difference in composition between the day milk and night milk of dairy cows.
33865587	9	18	theme	night	1169:1173	arg1	milk					1175:1178	night milk	1169:1178	night milk	1169:1178	Though milk fat, protein, lactose, and total milk solids were not different between day milk and night milk, small molecules, metabolites and lipids, and hormones and cytokines differed between day milk and night milk.
33865587	10	19	theme	HSP90	1284:1288	arg1	lower					1309:1313	lower	1309:1313	lower	1309:1313	Regarding biochemical and immune-related indicators, the concentrations of malondialdehyde, HSP70, and HSP90 in night milk were lower than that in day milk.
33865587	10	19	theme	HSP90	1284:1288	arg1	concentrations					1238:1251	the concentrations	1234:1251	the concentrations of malondialdehyde, HSP70, and HSP90 in night milk	1234:1302	Regarding biochemical and immune-related indicators, the concentrations of malondialdehyde, HSP70, and HSP90 in night milk were lower than that in day milk.
33865587	0	20	from	Effects	0:6	arg1	composition					40:50	milk composition	35:50	milk composition in dairy cows	35:64	Effects of the circadian rhythm on milk composition in dairy cows: Does day milk differ from night milk?
33865587	3	21	from	difference	318:327	arg1	composition					332:342	composition	332:342	composition	332:342	The aim of the present study was to investigate the difference in composition between the day milk and night milk of dairy cows.
33865587	1	22	from	Metabolism	105:114	arg1	organisms					124:132	most organisms	119:132	most organisms	119:132	Metabolism in most organisms can show variations between the day and night.
33865587	4	23	theme	Holstein	411:418	arg1	cows					420:423	Ten multiparous Holstein cows	395:423	Ten multiparous Holstein cows (milk yield = 25.2 ± 5.00 kg/d)	395:455	Ten multiparous Holstein cows (milk yield = 25.2 ± 5.00 kg/d) were randomly selected during mid lactation.
33865587	17	24	theme	milk	1978:1981	arg1	composition					1957:1967	the composition	1953:1967	the composition of night milk	1953:1981	The present findings show that the composition of night milk differs considerably from that of day milk.
33865587	8	25	theme	antioxidant	915:925	arg1	parameters					938:947	antioxidant and immune parameters	915:947	antioxidant and immune parameters in the milk	915:959	An automatic biochemical analyzer and ELISA kits were used to determine biochemical indicators, as well as antioxidant and immune parameters in the milk.
33865587	10	26	theme	night	1293:1297	arg1	milk					1299:1302	night milk	1293:1302	night milk	1293:1302	Regarding biochemical and immune-related indicators, the concentrations of malondialdehyde, HSP70, and HSP90 in night milk were lower than that in day milk.
33865587	3	27	theme	night	369:373	arg1	milk					375:378	night milk	369:378	night milk	369:378	The aim of the present study was to investigate the difference in composition between the day milk and night milk of dairy cows.
33865587	8	28	theme	immune	931:936	arg1	parameters					938:947	antioxidant and immune parameters	915:947	antioxidant and immune parameters in the milk	915:959	An automatic biochemical analyzer and ELISA kits were used to determine biochemical indicators, as well as antioxidant and immune parameters in the milk.
33865587	5	29	theme	Milk	502:505	arg1	samples					507:513	Milk samples	502:513	Milk samples	502:513	Milk samples were collected at 0500 h ("night milk") and 1500 h ("day milk") and analyzed to determine their composition.
33865587	10	30	theme	immune-related	1207:1220	arg1	indicators					1222:1231	biochemical and immune-related indicators	1191:1231	biochemical and immune-related indicators	1191:1231	Regarding biochemical and immune-related indicators, the concentrations of malondialdehyde, HSP70, and HSP90 in night milk were lower than that in day milk.
33865587	9	31	theme	milk	969:972	arg1	fat					974:976	milk fat	969:976	milk fat	969:976	Though milk fat, protein, lactose, and total milk solids were not different between day milk and night milk, small molecules, metabolites and lipids, and hormones and cytokines differed between day milk and night milk.
33865587	4	32	dep	cows	420:423	arg1	yield					431:435	milk yield	426:435	milk yield = 25.2 ± 5.00 kg/d	426:454	Ten multiparous Holstein cows (milk yield = 25.2 ± 5.00 kg/d) were randomly selected during mid lactation.
33865587	16	33	theme	aromatic	1842:1849	arg1	compounds					1851:1859	aromatic compounds	1842:1859	aromatic compounds	1842:1859	However, the other 33 metabolites analyzed, including carbohydrates, lipids, AA, and aromatic compounds, showed lower concentrations in day milk than in night milk.
33865587	3	34	theme	cows	389:392	arg1	milk					360:363	day milk	356:363	day milk	356:363	The aim of the present study was to investigate the difference in composition between the day milk and night milk of dairy cows.
33865587	3	34	theme	cows	389:392	arg1	milk					375:378	night milk	369:378	night milk	369:378	The aim of the present study was to investigate the difference in composition between the day milk and night milk of dairy cows.
33865587	0	35	theme	rhythm	25:30	arg1	Effects					0:6	Effects	0:6	Effects of the circadian rhythm on milk composition in dairy cows	0:64	Effects of the circadian rhythm on milk composition in dairy cows: Does day milk differ from night milk?
33865587	13	36	from	milk	1519:1522	arg1	levels					1488:1493	the levels	1484:1493	the levels of some lipids in night milk	1484:1522	Lipidomics analyses showed that the levels of some lipids in night milk were higher than those in day milk.
33865587	13	36	from	milk	1519:1522	arg1	higher					1529:1534	higher	1529:1534	higher	1529:1534	Lipidomics analyses showed that the levels of some lipids in night milk were higher than those in day milk.
33865587	14	37	theme	different	1596:1604	arg1	metabolites					1606:1616	36 different metabolites	1593:1616	36 different metabolites between day milk and night milk	1593:1648	Metabolomics analyses identified 36 different metabolites between day milk and night milk.
33865587	17	38	theme	present	1926:1932	arg1	findings					1934:1941	The present findings	1922:1941	The present findings	1922:1941	The present findings show that the composition of night milk differs considerably from that of day milk.
33865587	0	39	theme	milk	35:38	arg1	composition					40:50	milk composition	35:50	milk composition in dairy cows	35:64	Effects of the circadian rhythm on milk composition in dairy cows: Does day milk differ from night milk?
33865587	4	40	dep	=	437:437	arg1	kg/d					451:454	25.2 ± 5.00 kg/d	439:454	25.2 ± 5.00 kg/d	439:454	Ten multiparous Holstein cows (milk yield = 25.2 ± 5.00 kg/d) were randomly selected during mid lactation.
33865587	17	41	theme	day	2017:2019	arg1	milk					2021:2024	day milk	2017:2024	day milk	2017:2024	The present findings show that the composition of night milk differs considerably from that of day milk.
33865587	15	42	theme	day	1747:1749	arg1	milk					1751:1754	day milk	1747:1754	day milk	1747:1754	Higher concentrations of N-acetyl-d-glucosamine, cis-aconitate, and d-sorbitol were observed in day milk.
33865587	16	43	theme	lower	1869:1873	arg1	concentrations					1875:1888	lower concentrations	1869:1888	lower concentrations in day milk	1869:1900	However, the other 33 metabolites analyzed, including carbohydrates, lipids, AA, and aromatic compounds, showed lower concentrations in day milk than in night milk.
33865587	11	44	theme	night	1382:1386	arg1	milk					1388:1391	night milk	1382:1391	night milk	1382:1391	However, interferon-γ levels were higher in night milk.
33865587	14	45	theme	Metabolomics	1560:1571	arg1	analyses					1573:1580	Metabolomics analyses	1560:1580	Metabolomics analyses	1560:1580	Metabolomics analyses identified 36 different metabolites between day milk and night milk.
33865587	8	46	theme	biochemical	821:831	arg1	analyzer					833:840	An automatic biochemical analyzer	808:840	An automatic biochemical analyzer	808:840	An automatic biochemical analyzer and ELISA kits were used to determine biochemical indicators, as well as antioxidant and immune parameters in the milk.
33865587	9	47	theme	total	1001:1005	arg1	solids					1012:1017	total milk solids	1001:1017	total milk solids	1001:1017	Though milk fat, protein, lactose, and total milk solids were not different between day milk and night milk, small molecules, metabolites and lipids, and hormones and cytokines differed between day milk and night milk.
33865587	16	48	theme	other	1770:1774	arg1	AA					1834:1835	AA	1834:1835	AA	1834:1835	However, the other 33 metabolites analyzed, including carbohydrates, lipids, AA, and aromatic compounds, showed lower concentrations in day milk than in night milk.
33865587	16	48	theme	other	1770:1774	arg1	metabolites					1779:1789	the other 33 metabolites	1766:1789	the other 33 metabolites	1766:1789	However, the other 33 metabolites analyzed, including carbohydrates, lipids, AA, and aromatic compounds, showed lower concentrations in day milk than in night milk.
33865587	16	48	theme	other	1770:1774	arg1	lipids					1826:1831	lipids	1826:1831	lipids	1826:1831	However, the other 33 metabolites analyzed, including carbohydrates, lipids, AA, and aromatic compounds, showed lower concentrations in day milk than in night milk.
33865587	16	48	theme	other	1770:1774	arg1	carbohydrates					1811:1823	carbohydrates	1811:1823	carbohydrates	1811:1823	However, the other 33 metabolites analyzed, including carbohydrates, lipids, AA, and aromatic compounds, showed lower concentrations in day milk than in night milk.
33865587	16	48	theme	other	1770:1774	arg1	compounds					1851:1859	aromatic compounds	1842:1859	aromatic compounds	1842:1859	However, the other 33 metabolites analyzed, including carbohydrates, lipids, AA, and aromatic compounds, showed lower concentrations in day milk than in night milk.
33865587	10	49	from	concentrations	1238:1251	arg1	milk					1299:1302	night milk	1293:1302	night milk	1293:1302	Regarding biochemical and immune-related indicators, the concentrations of malondialdehyde, HSP70, and HSP90 in night milk were lower than that in day milk.
33865587	15	50	theme	Higher	1651:1656	arg1	concentrations					1658:1671	Higher concentrations	1651:1671	Higher concentrations of N-acetyl-d-glucosamine, cis-aconitate, and d-sorbitol	1651:1728	Higher concentrations of N-acetyl-d-glucosamine, cis-aconitate, and d-sorbitol were observed in day milk.
33865587	5	51	theme	milk	548:551	arg1	"					552:552	"night milk"	541:552	"night milk"	541:552	Milk samples were collected at 0500 h ("night milk") and 1500 h ("day milk") and analyzed to determine their composition.
33865587	5	51	theme	milk	548:551	arg1	h					538:538	0500 h	533:538	0500 h ("night milk")	533:553	Milk samples were collected at 0500 h ("night milk") and 1500 h ("day milk") and analyzed to determine their composition.
33865587	7	52	theme	small	761:765	arg1	molecules					767:775	small molecules	761:775	small molecules	761:775	Metabolomics and lipidomics were used to detect and analyze small molecules and fatty acids, respectively.
33865587	19	53	theme	strategic	2144:2152	arg1	use					2154:2156	use	2154:2156	use	2154:2156	These results provide evidence to support the strategic use and classification of day milk and night milk.
33865587	14	54	theme	night	1639:1643	arg1	milk					1645:1648	night milk	1639:1648	night milk	1639:1648	Metabolomics analyses identified 36 different metabolites between day milk and night milk.
33865587	11	55	theme	interferon-γ	1347:1358	arg1	levels					1360:1365	interferon-γ levels	1347:1365	interferon-γ levels	1347:1365	However, interferon-γ levels were higher in night milk.
33865587	2	56	theme	products	233:240	arg1	composition					218:228	the composition	214:228	the composition of products derived from livestock	214:263	These variations may also affect the composition of products derived from livestock.
33865587	19	57	theme	milk	2184:2187	arg1	classification					2162:2175	classification	2162:2175	classification	2162:2175	These results provide evidence to support the strategic use and classification of day milk and night milk.
33865587	19	57	theme	milk	2184:2187	arg1	use					2154:2156	use	2154:2156	use	2154:2156	These results provide evidence to support the strategic use and classification of day milk and night milk.
33865587	13	58	theme	day	1550:1552	arg1	milk					1554:1557	day milk	1550:1557	day milk	1550:1557	Lipidomics analyses showed that the levels of some lipids in night milk were higher than those in day milk.
33865587	10	59	theme	malondialdehyde	1256:1270	arg1	lower					1309:1313	lower	1309:1313	lower	1309:1313	Regarding biochemical and immune-related indicators, the concentrations of malondialdehyde, HSP70, and HSP90 in night milk were lower than that in day milk.
33865587	10	59	theme	malondialdehyde	1256:1270	arg1	concentrations					1238:1251	the concentrations	1234:1251	the concentrations of malondialdehyde, HSP70, and HSP90 in night milk	1234:1302	Regarding biochemical and immune-related indicators, the concentrations of malondialdehyde, HSP70, and HSP90 in night milk were lower than that in day milk.
33865587	6	60	used	used	654:657	arg2	spectroscopy					637:648	Mid-infrared spectroscopy	624:648	Mid-infrared spectroscopy	624:648	Mid-infrared spectroscopy was used to analyze macronutrient content of milk.
33865587	19	61	dep	use	2154:2156	arg1	the					2140:2142	the	2140:2142	the	2140:2142	These results provide evidence to support the strategic use and classification of day milk and night milk.
33865587	15	62	theme	d-sorbitol	1719:1728	arg1	concentrations					1658:1671	Higher concentrations	1651:1671	Higher concentrations of N-acetyl-d-glucosamine, cis-aconitate, and d-sorbitol	1651:1728	Higher concentrations of N-acetyl-d-glucosamine, cis-aconitate, and d-sorbitol were observed in day milk.
33865587	0	63	theme	night	93:97	arg1	milk					99:102	night milk	93:102	night milk	93:102	Effects of the circadian rhythm on milk composition in dairy cows: Does day milk differ from night milk?
33865587	9	64	theme	night	1059:1063	arg1	milk					1065:1068	night milk	1059:1068	night milk	1059:1068	Though milk fat, protein, lactose, and total milk solids were not different between day milk and night milk, small molecules, metabolites and lipids, and hormones and cytokines differed between day milk and night milk.
33865587	19	65	theme	night	2193:2197	arg1	milk					2199:2202	night milk	2193:2202	night milk	2193:2202	These results provide evidence to support the strategic use and classification of day milk and night milk.
33865587	2	66	attach	derived	242:248	arg1	livestock					255:263	livestock	255:263	livestock	255:263	These variations may also affect the composition of products derived from livestock.
33865587	2	66	attach	derived	242:248	arg2	products					233:240	products	233:240	products derived from livestock	233:263	These variations may also affect the composition of products derived from livestock.
33865587	4	67	theme	multiparous	399:409	arg1	cows					420:423	Ten multiparous Holstein cows	395:423	Ten multiparous Holstein cows (milk yield = 25.2 ± 5.00 kg/d)	395:455	Ten multiparous Holstein cows (milk yield = 25.2 ± 5.00 kg/d) were randomly selected during mid lactation.
33865587	12	68	theme	night	1408:1412	arg1	milk					1414:1417	night milk	1408:1417	night milk	1408:1417	Additionally, night milk was naturally rich in melatonin.
33865587	5	69	theme	day	568:570	arg1	"					576:576	"day milk"	567:576	"day milk"	567:576	Milk samples were collected at 0500 h ("night milk") and 1500 h ("day milk") and analyzed to determine their composition.
33865587	5	69	theme	day	568:570	arg1	h					564:564	1500 h	559:564	1500 h ("day milk")	559:577	Milk samples were collected at 0500 h ("night milk") and 1500 h ("day milk") and analyzed to determine their composition.
33865587	0	70	theme	dairy	55:59	arg1	cows					61:64	dairy cows	55:64	dairy cows	55:64	Effects of the circadian rhythm on milk composition in dairy cows: Does day milk differ from night milk?
33865587	3	71	theme	study	289:293	arg1	aim					270:272	The aim	266:272	The aim of the present study	266:293	The aim of the present study was to investigate the difference in composition between the day milk and night milk of dairy cows.
33865587	4	72	theme	=	437:437	arg1	yield					431:435	milk yield	426:435	milk yield = 25.2 ± 5.00 kg/d	426:454	Ten multiparous Holstein cows (milk yield = 25.2 ± 5.00 kg/d) were randomly selected during mid lactation.
33865587	10	73	theme	day	1328:1330	arg1	milk					1332:1335	day milk	1328:1335	day milk	1328:1335	Regarding biochemical and immune-related indicators, the concentrations of malondialdehyde, HSP70, and HSP90 in night milk were lower than that in day milk.
33865587	1	74	theme	most	119:122	arg1	organisms					124:132	most organisms	119:132	most organisms	119:132	Metabolism in most organisms can show variations between the day and night.
33865587	4	75	theme	±	444:444	arg1	kg/d					451:454	25.2 ± 5.00 kg/d	439:454	25.2 ± 5.00 kg/d	439:454	Ten multiparous Holstein cows (milk yield = 25.2 ± 5.00 kg/d) were randomly selected during mid lactation.
33865587	13	76	theme	night	1513:1517	arg1	milk					1519:1522	night milk	1513:1522	night milk	1513:1522	Lipidomics analyses showed that the levels of some lipids in night milk were higher than those in day milk.
33865587	16	77	theme	day	1893:1895	arg1	milk					1897:1900	day milk	1893:1900	day milk	1893:1900	However, the other 33 metabolites analyzed, including carbohydrates, lipids, AA, and aromatic compounds, showed lower concentrations in day milk than in night milk.
33865587	0	78	theme	day	72:74	arg1	milk					76:79	day milk	72:79	day milk	72:79	Effects of the circadian rhythm on milk composition in dairy cows: Does day milk differ from night milk?
33865587	0	79	from	composition	40:50	arg1	cows					61:64	dairy cows	55:64	dairy cows	55:64	Effects of the circadian rhythm on milk composition in dairy cows: Does day milk differ from night milk?
33865587	10	80	theme	HSP70	1273:1277	arg1	lower					1309:1313	lower	1309:1313	lower	1309:1313	Regarding biochemical and immune-related indicators, the concentrations of malondialdehyde, HSP70, and HSP90 in night milk were lower than that in day milk.
33865587	10	80	theme	HSP70	1273:1277	arg1	concentrations					1238:1251	the concentrations	1234:1251	the concentrations of malondialdehyde, HSP70, and HSP90 in night milk	1234:1302	Regarding biochemical and immune-related indicators, the concentrations of malondialdehyde, HSP70, and HSP90 in night milk were lower than that in day milk.
33865587	17	81	theme	night	1972:1976	arg1	milk					1978:1981	night milk	1972:1981	night milk	1972:1981	The present findings show that the composition of night milk differs considerably from that of day milk.
33865587	13	82	from	levels	1488:1493	arg1	milk					1519:1522	night milk	1513:1522	night milk	1513:1522	Lipidomics analyses showed that the levels of some lipids in night milk were higher than those in day milk.
33865587	18	83	theme	milk	2080:2083	arg1	composition					2085:2095	milk composition	2080:2095	milk composition	2080:2095	Notable changes in the circadian rhythm also altered milk composition.
33865587	4	84	theme	milk	426:429	arg1	yield					431:435	milk yield	426:435	milk yield = 25.2 ± 5.00 kg/d	426:454	Ten multiparous Holstein cows (milk yield = 25.2 ± 5.00 kg/d) were randomly selected during mid lactation.
33865587	3	85	theme	dairy	383:387	arg1	cows					389:392	dairy cows	383:392	dairy cows	383:392	The aim of the present study was to investigate the difference in composition between the day milk and night milk of dairy cows.
33865587	9	86	theme	day	1156:1158	arg1	milk					1160:1163	day milk	1156:1163	day milk	1156:1163	Though milk fat, protein, lactose, and total milk solids were not different between day milk and night milk, small molecules, metabolites and lipids, and hormones and cytokines differed between day milk and night milk.
33865587	15	87	located	observed	1735:1742	arg2	concentrations					1658:1671	Higher concentrations	1651:1671	Higher concentrations of N-acetyl-d-glucosamine, cis-aconitate, and d-sorbitol	1651:1728	Higher concentrations of N-acetyl-d-glucosamine, cis-aconitate, and d-sorbitol were observed in day milk.
33865587	15	87	located	observed	1735:1742	arg1	milk					1751:1754	day milk	1747:1754	day milk	1747:1754	Higher concentrations of N-acetyl-d-glucosamine, cis-aconitate, and d-sorbitol were observed in day milk.
33865587	13	88	theme	lipids	1503:1508	arg1	levels					1488:1493	the levels	1484:1493	the levels of some lipids in night milk	1484:1522	Lipidomics analyses showed that the levels of some lipids in night milk were higher than those in day milk.
33865587	13	88	theme	lipids	1503:1508	arg1	higher					1529:1534	higher	1529:1534	higher	1529:1534	Lipidomics analyses showed that the levels of some lipids in night milk were higher than those in day milk.
33865587	0	89	theme	circadian	15:23	arg1	rhythm					25:30	the circadian rhythm	11:30	the circadian rhythm	11:30	Effects of the circadian rhythm on milk composition in dairy cows: Does day milk differ from night milk?
33865587	13	90	from	lipids	1503:1508	arg1	milk					1519:1522	night milk	1513:1522	night milk	1513:1522	Lipidomics analyses showed that the levels of some lipids in night milk were higher than those in day milk.
33865587	12	91	from	rich	1433:1436	arg1	melatonin					1441:1449	melatonin	1441:1449	melatonin	1441:1449	Additionally, night milk was naturally rich in melatonin.
33865587	10	92	theme	biochemical	1191:1201	arg1	indicators					1222:1231	biochemical and immune-related indicators	1191:1231	biochemical and immune-related indicators	1191:1231	Regarding biochemical and immune-related indicators, the concentrations of malondialdehyde, HSP70, and HSP90 in night milk were lower than that in day milk.
33865587	4	93	theme	mid	487:489	arg1	lactation					491:499	mid lactation	487:499	mid lactation	487:499	Ten multiparous Holstein cows (milk yield = 25.2 ± 5.00 kg/d) were randomly selected during mid lactation.
33865587	16	94	from	concentrations	1875:1888	arg1	milk					1897:1900	day milk	1893:1900	day milk	1893:1900	However, the other 33 metabolites analyzed, including carbohydrates, lipids, AA, and aromatic compounds, showed lower concentrations in day milk than in night milk.
33865587	6	95	theme	Mid-infrared	624:635	arg1	spectroscopy					637:648	Mid-infrared spectroscopy	624:648	Mid-infrared spectroscopy	624:648	Mid-infrared spectroscopy was used to analyze macronutrient content of milk.
33865587	8	96	from	parameters	938:947	arg1	milk					956:959	the milk	952:959	the milk	952:959	An automatic biochemical analyzer and ELISA kits were used to determine biochemical indicators, as well as antioxidant and immune parameters in the milk.
33865587	18	97	theme	Notable	2027:2033	arg1	changes					2035:2041	Notable changes	2027:2041	Notable changes in the circadian rhythm	2027:2065	Notable changes in the circadian rhythm also altered milk composition.
33865587	3	98	theme	day	356:358	arg1	milk					360:363	day milk	356:363	day milk	356:363	The aim of the present study was to investigate the difference in composition between the day milk and night milk of dairy cows.
33865587	7	99	theme	fatty	781:785	arg1	acids					787:791	fatty acids	781:791	fatty acids	781:791	Metabolomics and lipidomics were used to detect and analyze small molecules and fatty acids, respectively.
33865587	13	100	theme	Lipidomics	1452:1461	arg1	analyses					1463:1470	Lipidomics analyses	1452:1470	Lipidomics analyses	1452:1470	Lipidomics analyses showed that the levels of some lipids in night milk were higher than those in day milk.
33865587	6	101	theme	milk	695:698	arg1	content					684:690	macronutrient content	670:690	macronutrient content of milk	670:698	Mid-infrared spectroscopy was used to analyze macronutrient content of milk.
33865587	8	102	theme	automatic	811:819	arg1	analyzer					833:840	An automatic biochemical analyzer	808:840	An automatic biochemical analyzer	808:840	An automatic biochemical analyzer and ELISA kits were used to determine biochemical indicators, as well as antioxidant and immune parameters in the milk.
33865587	18	103	theme	circadian	2050:2058	arg1	rhythm					2060:2065	the circadian rhythm	2046:2065	the circadian rhythm	2046:2065	Notable changes in the circadian rhythm also altered milk composition.
33865587	15	104	theme	N-acetyl-d-glucosamine	1676:1697	arg1	concentrations					1658:1671	Higher concentrations	1651:1671	Higher concentrations of N-acetyl-d-glucosamine, cis-aconitate, and d-sorbitol	1651:1728	Higher concentrations of N-acetyl-d-glucosamine, cis-aconitate, and d-sorbitol were observed in day milk.
33865587	1	105	dep	day	166:168	arg1	the					162:164	the	162:164	the	162:164	Metabolism in most organisms can show variations between the day and night.
33865587	9	106	theme	milk	1007:1010	arg1	solids					1012:1017	total milk solids	1001:1017	total milk solids	1001:1017	Though milk fat, protein, lactose, and total milk solids were not different between day milk and night milk, small molecules, metabolites and lipids, and hormones and cytokines differed between day milk and night milk.
31978471	3	0	with	groups	560:565	arg1	surface					583:589	the surface	579:589	the surface of MMT	579:596	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	5	1	theme	interaction	1000:1010	arg1	COOH					940:943	The OH and COOH or NH2 groups	929:957	COOH	940:943	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	1	theme	interaction	1000:1010	arg1	groups					952:957	The OH and COOH or NH2 groups	929:957	groups	952:957	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	1	theme	interaction	1000:1010	arg1	OH					933:934	The OH and COOH or NH2 groups	929:957	OH	933:934	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	1	theme	interaction	1000:1010	arg1	chains					966:971	CMC chains	962:971	CMC chains	962:971	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	1	theme	interaction	1000:1010	arg1	sites					1019:1023	electrostatic interaction active sites	986:1023	electrostatic interaction active sites	986:1023	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	4	2	theme	adsorption	772:781	arg1	effect					783:788	the adsorption effect	768:788	the adsorption effect of CMC-MMT was compared with Na-MMT and CMC	768:832	Batch experiments were executed to investigate the adsorption effect of CMC-MMT was compared with Na-MMT and CMC.
31978471	3	3	theme	carboxyl	551:558	arg1	CMC					570:572	CMC	570:572	CMC	570:572	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	3	3	theme	carboxyl	551:558	arg1	groups					560:565	hydroxyl & carboxyl groups	540:565	hydroxyl & carboxyl groups of CMC with the surface of MMT	540:596	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	6	4	theme	kinetic	1308:1314	arg1	studies					1329:1335	The kinetic and isotherm studies	1304:1335	studies	1329:1335	The kinetic and isotherm studies indicated that the pseudo-second-order and the Langmuir model well described the adsorption equilibrium of Pb(II) and CR on CMC-MMT.
31978471	6	5	theme	isotherm	1320:1327	arg1	studies					1329:1335	The kinetic and isotherm studies	1304:1335	studies	1329:1335	The kinetic and isotherm studies indicated that the pseudo-second-order and the Langmuir model well described the adsorption equilibrium of Pb(II) and CR on CMC-MMT.
31978471	3	6	theme	der	603:605	arg1	interaction					613:623	Van der Waals interaction	599:623	Van der Waals interaction	599:623	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	5	7	theme	NH2	948:950	arg1	OH					933:934	The OH and COOH or NH2 groups	929:957	OH	933:934	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	7	theme	NH2	948:950	arg1	sites					1019:1023	electrostatic interaction active sites	986:1023	electrostatic interaction active sites	986:1023	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	7	theme	NH2	948:950	arg1	COOH					940:943	The OH and COOH or NH2 groups	929:957	COOH	940:943	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	7	theme	NH2	948:950	arg1	chains					966:971	CMC chains	962:971	CMC chains	962:971	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	7	theme	NH2	948:950	arg1	sites					1042:1046	coordination sites	1029:1046	coordination sites	1029:1046	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	7	theme	NH2	948:950	arg1	groups					952:957	The OH and COOH or NH2 groups	929:957	groups	952:957	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	3	8	theme	Waals	607:611	arg1	interaction					613:623	Van der Waals interaction	599:623	Van der Waals interaction	599:623	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	5	9	theme	organic	1282:1288	arg1	CR					1300:1301	organic pollutant CR	1282:1301	organic pollutant CR	1282:1301	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	6	10	theme	Langmuir	1384:1391	arg1	model					1393:1397	the pseudo-second-order and the Langmuir model	1352:1397	model	1393:1397	The kinetic and isotherm studies indicated that the pseudo-second-order and the Langmuir model well described the adsorption equilibrium of Pb(II) and CR on CMC-MMT.
31978471	3	11	theme	MMT	716:718	arg1	surface					705:711	the surface	701:711	the surface of MMT	701:718	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	5	12	theme	chains	966:971	arg1	OH					933:934	The OH and COOH or NH2 groups	929:957	OH	933:934	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	12	theme	chains	966:971	arg1	sites					1019:1023	electrostatic interaction active sites	986:1023	electrostatic interaction active sites	986:1023	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	12	theme	chains	966:971	arg1	COOH					940:943	The OH and COOH or NH2 groups	929:957	COOH	940:943	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	12	theme	chains	966:971	arg1	chains					966:971	CMC chains	962:971	CMC chains	962:971	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	12	theme	chains	966:971	arg1	sites					1042:1046	coordination sites	1029:1046	coordination sites	1029:1046	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	12	theme	chains	966:971	arg1	groups					952:957	The OH and COOH or NH2 groups	929:957	groups	952:957	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	3	13	theme	MMT	496:498	arg1	surface					485:491	the interlayer space and surface	460:491	surface	485:491	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	3	13	theme	MMT	496:498	arg1	space					475:479	the interlayer space and surface	460:491	space	475:479	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	5	14	theme	pollutant	1290:1298	arg1	CR					1300:1301	organic pollutant CR	1282:1301	organic pollutant CR	1282:1301	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	3	15	contain	had	669:671	arg2	interaction					684:694	n't obvious interaction	672:694	n't obvious interaction with the surface of MMT	672:718	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	3	15	contain	had	669:671	arg1	CMC					665:667	CMC	665:667	CMC	665:667	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	3	15	contain	had	669:671	arg1	groups					655:660	amino groups	649:660	amino groups of CMC	649:667	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	5	16	dep	exhibited	867:875	arg1	serve					977:981	serve	977:981	may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR	973:1301	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	0	17	theme	red	94:96	arg1	montmorillonite					43:57	carboxymethyl chitosan hybrid montmorillonite	13:57	carboxymethyl chitosan hybrid montmorillonite	13:57	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.
31978471	0	17	theme	red	94:96	arg1	adsorption					63:72	adsorption	63:72	adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite	63:142	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.
31978471	3	18	with	interaction	684:694	arg1	surface					705:711	the surface	701:711	the surface of MMT	701:718	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	4	19	dep	Na-MMT	819:824	arg1	was					801:803	was	801:803	was compared with Na-MMT and CMC	801:832	Batch experiments were executed to investigate the adsorption effect of CMC-MMT was compared with Na-MMT and CMC.
31978471	5	20	theme	higher	881:886	arg1	capacity					899:906	the higher adsorption capacity	877:906	the higher adsorption capacity	877:906	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	21	theme	surface	1194:1200	arg1	sites					1209:1213	surface active sites	1194:1213	more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR	1189:1301	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	2	22	theme	MMT	403:405	arg1	mechanism					379:387	the mechanism	375:387	the mechanism of CMC hybrid MMT	375:405	Molecular dynamics(MD) simulation was carried out to reveal the mechanism of CMC hybrid MMT.
31978471	5	23	dep	，and	1111:1114	arg1	II					1108:1109	II	1108:1109	II	1108:1109	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	24	theme	active	1012:1017	arg1	COOH					940:943	The OH and COOH or NH2 groups	929:957	COOH	940:943	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	24	theme	active	1012:1017	arg1	groups					952:957	The OH and COOH or NH2 groups	929:957	groups	952:957	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	24	theme	active	1012:1017	arg1	OH					933:934	The OH and COOH or NH2 groups	929:957	OH	933:934	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	24	theme	active	1012:1017	arg1	chains					966:971	CMC chains	962:971	CMC chains	962:971	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	24	theme	active	1012:1017	arg1	sites					1019:1023	electrostatic interaction active sites	986:1023	electrostatic interaction active sites	986:1023	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	1	25	theme	organic-inorganic	198:214	arg1	material					223:230	The carboxymethyl-chitosan-montmorillonite (CMC-MMT) organic-inorganic hybrid material	145:230	The carboxymethyl-chitosan-montmorillonite (CMC-MMT) organic-inorganic hybrid material	145:230	The carboxymethyl-chitosan-montmorillonite (CMC-MMT) organic-inorganic hybrid material was applied to adsorb Pb(II) and Congo red (CR) anionic dye from aqueous solution.
31978471	2	26	theme	hybrid	396:401	arg1	MMT					403:405	CMC hybrid MMT	392:405	CMC hybrid MMT	392:405	Molecular dynamics(MD) simulation was carried out to reveal the mechanism of CMC hybrid MMT.
31978471	3	27	theme	CMC	665:667	arg1	CMC					665:667	CMC	665:667	CMC	665:667	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	3	27	theme	CMC	665:667	arg1	groups					655:660	amino groups	649:660	amino groups of CMC	649:667	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	0	28	theme	CMC-MMT	101:107	arg1	composite					134:142	CMC-MMT organic-inorganic hybrid composite	101:142	CMC-MMT organic-inorganic hybrid composite	101:142	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.
31978471	5	29	theme	CR	1300:1301	arg1	adsorption					1268:1277	the adsorption	1264:1277	the adsorption of organic pollutant CR	1264:1301	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	1	30	theme	hybrid	216:221	arg1	material					223:230	The carboxymethyl-chitosan-montmorillonite (CMC-MMT) organic-inorganic hybrid material	145:230	The carboxymethyl-chitosan-montmorillonite (CMC-MMT) organic-inorganic hybrid material	145:230	The carboxymethyl-chitosan-montmorillonite (CMC-MMT) organic-inorganic hybrid material was applied to adsorb Pb(II) and Congo red (CR) anionic dye from aqueous solution.
31978471	2	31	theme	CMC	392:394	arg1	MMT					403:405	CMC hybrid MMT	392:405	CMC hybrid MMT	392:405	Molecular dynamics(MD) simulation was carried out to reveal the mechanism of CMC hybrid MMT.
31978471	3	32	theme	amino	649:653	arg1	CMC					665:667	CMC	665:667	CMC	665:667	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	3	32	theme	amino	649:653	arg1	groups					655:660	amino groups	649:660	amino groups of CMC	649:667	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	1	33	dep	Pb	254:255	arg1	dye					288:290	anionic dye	280:290	anionic dye	280:290	The carboxymethyl-chitosan-montmorillonite (CMC-MMT) organic-inorganic hybrid material was applied to adsorb Pb(II) and Congo red (CR) anionic dye from aqueous solution.
31978471	3	34	theme	hydrogen	501:508	arg1	bonds					510:514	hydrogen bonds	501:514	hydrogen bonds	501:514	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	5	35	theme	MMT	1171:1173	arg1	space					1162:1166	the inter-layer space	1146:1166	the inter-layer space of MMT	1146:1173	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	0	36	theme	montmorillonite	43:57	arg1	Mechanism					0:8	Mechanism	0:8	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.	0:143	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.
31978471	5	37	theme	adsorption	1068:1077	arg1	performance					1079:1089	the adsorption performance	1064:1089	the adsorption performance of CMC-MMT on Pb(II)，and	1064:1114	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	0	38	theme	hybrid	127:132	arg1	composite					134:142	CMC-MMT organic-inorganic hybrid composite	101:142	CMC-MMT organic-inorganic hybrid composite	101:142	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.
31978471	5	39	from	sites	1209:1213	arg1	composite					1237:1245	the CMC-MMT hybrid composite	1218:1245	the CMC-MMT hybrid composite	1218:1245	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	0	40	theme	hybrid	36:41	arg1	montmorillonite					43:57	carboxymethyl chitosan hybrid montmorillonite	13:57	carboxymethyl chitosan hybrid montmorillonite	13:57	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.
31978471	1	41	theme	anionic	280:286	arg1	dye					288:290	anionic dye	280:290	anionic dye	280:290	The carboxymethyl-chitosan-montmorillonite (CMC-MMT) organic-inorganic hybrid material was applied to adsorb Pb(II) and Congo red (CR) anionic dye from aqueous solution.
31978471	0	42	theme	organic-inorganic	109:125	arg1	composite					134:142	CMC-MMT organic-inorganic hybrid composite	101:142	CMC-MMT organic-inorganic hybrid composite	101:142	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.
31978471	3	43	theme	CMC	570:572	arg1	CMC					570:572	CMC	570:572	CMC	570:572	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	3	43	theme	CMC	570:572	arg1	groups					560:565	hydroxyl & carboxyl groups	540:565	hydroxyl & carboxyl groups of CMC with the surface of MMT	540:596	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	0	44	theme	chitosan	27:34	arg1	montmorillonite					43:57	carboxymethyl chitosan hybrid montmorillonite	13:57	carboxymethyl chitosan hybrid montmorillonite	13:57	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.
31978471	5	45	theme	CMC-MMT	1222:1228	arg1	composite					1237:1245	the CMC-MMT hybrid composite	1218:1245	the CMC-MMT hybrid composite	1218:1245	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	0	46	theme	adsorption	63:72	arg1	Mechanism					0:8	Mechanism	0:8	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.	0:143	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.
31978471	3	47	theme	obvious	676:682	arg1	interaction					684:694	n't obvious interaction	672:694	n't obvious interaction with the surface of MMT	672:718	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	5	48	theme	CMC	962:964	arg1	chains					966:971	CMC chains	962:971	CMC chains	962:971	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	49	theme	hybrid	1230:1235	arg1	composite					1237:1245	the CMC-MMT hybrid composite	1218:1245	the CMC-MMT hybrid composite	1218:1245	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	2	50	theme	dynamics	325:332	arg1	simulation					338:347	Molecular dynamics(MD) simulation	315:347	Molecular dynamics(MD) simulation	315:347	Molecular dynamics(MD) simulation was carried out to reveal the mechanism of CMC hybrid MMT.
31978471	5	51	dep	improved	1055:1062	arg1	enlarged					1137:1144	enlarged	1137:1144	enlarged	1137:1144	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	6	52	theme	CR	1455:1456	arg1	equilibrium					1429:1439	the adsorption equilibrium	1414:1439	the adsorption equilibrium of Pb(II) and CR	1414:1456	The kinetic and isotherm studies indicated that the pseudo-second-order and the Langmuir model well described the adsorption equilibrium of Pb(II) and CR on CMC-MMT.
31978471	4	53	theme	CMC-MMT	793:799	arg1	effect					783:788	the adsorption effect	768:788	the adsorption effect of CMC-MMT was compared with Na-MMT and CMC	768:832	Batch experiments were executed to investigate the adsorption effect of CMC-MMT was compared with Na-MMT and CMC.
31978471	4	54	theme	Batch	721:725	arg1	experiments					727:737	Batch experiments	721:737	Batch experiments	721:737	Batch experiments were executed to investigate the adsorption effect of CMC-MMT was compared with Na-MMT and CMC.
31978471	2	55	theme	Molecular	315:323	arg1	MD					334:335	MD	334:335	MD	334:335	Molecular dynamics(MD) simulation was carried out to reveal the mechanism of CMC hybrid MMT.
31978471	2	55	theme	Molecular	315:323	arg1	dynamics					325:332	Molecular dynamics	315:332	Molecular dynamics(MD) simulation	315:347	Molecular dynamics(MD) simulation was carried out to reveal the mechanism of CMC hybrid MMT.
31978471	5	56	theme	CMC	1133:1135	arg1	insertion					1120:1128	the insertion	1116:1128	the insertion of CMC	1116:1135	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	1	57	theme	aqueous	297:303	arg1	solution					305:312	aqueous solution	297:312	aqueous solution	297:312	The carboxymethyl-chitosan-montmorillonite (CMC-MMT) organic-inorganic hybrid material was applied to adsorb Pb(II) and Congo red (CR) anionic dye from aqueous solution.
31978471	3	58	theme	Van	599:601	arg1	interaction					613:623	Van der Waals interaction	599:623	Van der Waals interaction	599:623	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	5	59	theme	adsorption	888:897	arg1	capacity					899:906	the higher adsorption capacity	877:906	the higher adsorption capacity	877:906	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	3	60	theme	hydroxyl	540:547	arg1	CMC					570:572	CMC	570:572	CMC	570:572	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	3	60	theme	hydroxyl	540:547	arg1	groups					560:565	hydroxyl & carboxyl groups	540:565	hydroxyl & carboxyl groups of CMC with the surface of MMT	540:596	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	5	61	theme	Pb	1105:1106	arg1	，and					1111:1114	Pb(II)，and	1105:1114	Pb(II)，and	1105:1114	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	6	62	theme	Pb	1444:1445	arg1	equilibrium					1429:1439	the adsorption equilibrium	1414:1439	the adsorption equilibrium of Pb(II) and CR	1414:1456	The kinetic and isotherm studies indicated that the pseudo-second-order and the Langmuir model well described the adsorption equilibrium of Pb(II) and CR on CMC-MMT.
31978471	5	63	theme	active	1202:1207	arg1	sites					1209:1213	surface active sites	1194:1213	more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR	1189:1301	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	64	from	performance	1079:1089	arg1	，and					1111:1114	Pb(II)，and	1105:1114	Pb(II)，and	1105:1114	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	0	65	theme	Pb	77:78	arg1	montmorillonite					43:57	carboxymethyl chitosan hybrid montmorillonite	13:57	carboxymethyl chitosan hybrid montmorillonite	13:57	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.
31978471	0	65	theme	Pb	77:78	arg1	adsorption					63:72	adsorption	63:72	adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite	63:142	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.
31978471	3	66	theme	MMT	594:596	arg1	surface					583:589	the surface	579:589	the surface of MMT	579:596	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	3	67	theme	&	549:549	arg1	CMC					570:572	CMC	570:572	CMC	570:572	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	3	67	theme	&	549:549	arg1	groups					560:565	hydroxyl & carboxyl groups	540:565	hydroxyl & carboxyl groups of CMC with the surface of MMT	540:596	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	3	68	theme	interlayer	464:473	arg1	space					475:479	the interlayer space and surface	460:491	space	475:479	The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT.
31978471	5	69	theme	inter-layer	1150:1160	arg1	space					1162:1166	the inter-layer space	1146:1166	the inter-layer space of MMT	1146:1173	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	70	theme	CMC-MMT	1094:1100	arg1	performance					1079:1089	the adsorption performance	1064:1089	the adsorption performance of CMC-MMT on Pb(II)，and	1064:1114	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	71	theme	electrostatic	986:998	arg1	COOH					940:943	The OH and COOH or NH2 groups	929:957	COOH	940:943	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	71	theme	electrostatic	986:998	arg1	groups					952:957	The OH and COOH or NH2 groups	929:957	groups	952:957	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	71	theme	electrostatic	986:998	arg1	OH					933:934	The OH and COOH or NH2 groups	929:957	OH	933:934	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	71	theme	electrostatic	986:998	arg1	chains					966:971	CMC chains	962:971	CMC chains	962:971	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	71	theme	electrostatic	986:998	arg1	sites					1019:1023	electrostatic interaction active sites	986:1023	electrostatic interaction active sites	986:1023	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	0	72	theme	carboxymethyl	13:25	arg1	montmorillonite					43:57	carboxymethyl chitosan hybrid montmorillonite	13:57	carboxymethyl chitosan hybrid montmorillonite	13:57	Mechanism of carboxymethyl chitosan hybrid montmorillonite and adsorption of Pb(II) and Congo red by CMC-MMT organic-inorganic hybrid composite.
31978471	6	73	theme	adsorption	1418:1427	arg1	equilibrium					1429:1439	the adsorption equilibrium	1414:1439	the adsorption equilibrium of Pb(II) and CR	1414:1456	The kinetic and isotherm studies indicated that the pseudo-second-order and the Langmuir model well described the adsorption equilibrium of Pb(II) and CR on CMC-MMT.
31978471	5	74	theme	coordination	1029:1040	arg1	sites					1042:1046	coordination sites	1029:1046	coordination sites	1029:1046	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	74	theme	coordination	1029:1040	arg1	COOH					940:943	The OH and COOH or NH2 groups	929:957	COOH	940:943	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	74	theme	coordination	1029:1040	arg1	OH					933:934	The OH and COOH or NH2 groups	929:957	OH	933:934	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	74	theme	coordination	1029:1040	arg1	chains					966:971	CMC chains	962:971	CMC chains	962:971	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
31978471	5	74	theme	coordination	1029:1040	arg1	groups					952:957	The OH and COOH or NH2 groups	929:957	groups	952:957	The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR.
34048927	4	0	theme	study	462:466	arg1	aim					450:452	the aim	446:452	the aim of this study	446:466	Thus, the aim of this study was to investigate the anomeric composition of lactose powders after heating in a differential scanning calorimeter.
34048927	2	1	from	prone	280:284	arg1	solution					233:240	aqueous solution	225:240	aqueous solution	225:240	Despite the assumption of chemical stability, in aqueous solution, the chiral composition of lactose is prone to change.
34048927	0	2	theme	solid-state	75:85	arg1	epimerization					87:99	solid-state epimerization	75:99	solid-state epimerization	75:99	Stability of α-lactose monohydrate: The discovery of dehydration triggered solid-state epimerization.
34048927	9	3	theme	additional	1240:1249	arg1	degradation					1260:1270	no additional chemical degradation	1237:1270	no additional chemical degradation detected by NMR	1237:1286	Optical microscopy indicated that the solid-state was maintained throughout thermal desorption and up to the onset of melting at 214.2 ± 0.9 °C. Only epimerisation was observed, with no additional chemical degradation detected by NMR.
34048927	10	4	theme	%	1397:1397	arg1	conversion					1373:1382	a conversion	1371:1382	a conversion of 29.1 ± 0.7% to β-lactose	1371:1410	Similar results were observed when heating α-lactose to 190 °C, which resulted in a conversion of 29.1 ± 0.7% to β-lactose.
34048927	6	5	theme	suffered	806:813	arg1	160 °C					776:781	160 °C	776:781	160 °C	776:781	The onset for monohydrate desorption occurred at 143.8 ± 0.3 °C. Post water-loss, at 160 °C for example, α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer.
34048927	6	5	theme	suffered	806:813	arg1	conversion					823:832	α-lactose suffered partial conversion	796:832	α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer	796:862	The onset for monohydrate desorption occurred at 143.8 ± 0.3 °C. Post water-loss, at 160 °C for example, α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer.
34048927	6	5	theme	suffered	806:813	arg1	%					845:845	11.6 ± 0.9%	835:845	11.6 ± 0.9%	835:845	The onset for monohydrate desorption occurred at 143.8 ± 0.3 °C. Post water-loss, at 160 °C for example, α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer.
34048927	11	6	theme	exothermic	1423:1432	arg1	peak					1434:1437	the exothermic peak	1419:1437	the exothermic peak observed after monohydrate loss, which has often been attributed to re-crystallisation,	1419:1525	Thus, the exothermic peak observed after monohydrate loss, which has often been attributed to re-crystallisation, comprises a contribution from epimerisation.
34048927	13	7	theme	hydrate	1721:1727	arg1	dehydration					1741:1751	dehydration	1741:1751	dehydration	1741:1751	In summary, it has been shown unequivocally for the first time that hydrate desorption (dehydration) leads to solid-state epimerisation in α-lactose powders.
34048927	13	7	theme	hydrate	1721:1727	arg1	desorption					1729:1738	hydrate desorption	1721:1738	hydrate desorption (dehydration)	1721:1752	In summary, it has been shown unequivocally for the first time that hydrate desorption (dehydration) leads to solid-state epimerisation in α-lactose powders.
34048927	9	8	theme	chemical	1251:1258	arg1	degradation					1260:1270	no additional chemical degradation	1237:1270	no additional chemical degradation detected by NMR	1237:1286	Optical microscopy indicated that the solid-state was maintained throughout thermal desorption and up to the onset of melting at 214.2 ± 0.9 °C. Only epimerisation was observed, with no additional chemical degradation detected by NMR.
34048927	6	9	theme	α-lactose	796:804	arg1	160 °C					776:781	160 °C	776:781	160 °C	776:781	The onset for monohydrate desorption occurred at 143.8 ± 0.3 °C. Post water-loss, at 160 °C for example, α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer.
34048927	6	9	theme	α-lactose	796:804	arg1	conversion					823:832	α-lactose suffered partial conversion	796:832	α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer	796:862	The onset for monohydrate desorption occurred at 143.8 ± 0.3 °C. Post water-loss, at 160 °C for example, α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer.
34048927	6	9	theme	α-lactose	796:804	arg1	%					845:845	11.6 ± 0.9%	835:845	11.6 ± 0.9%	835:845	The onset for monohydrate desorption occurred at 143.8 ± 0.3 °C. Post water-loss, at 160 °C for example, α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer.
34048927	11	10	theme	monohydrate	1454:1464	arg1	loss					1466:1469	monohydrate loss	1454:1469	monohydrate loss	1454:1469	Thus, the exothermic peak observed after monohydrate loss, which has often been attributed to re-crystallisation, comprises a contribution from epimerisation.
34048927	4	11	theme	scanning	563:570	arg1	calorimeter					572:582	a differential scanning calorimeter	548:582	a differential scanning calorimeter	548:582	Thus, the aim of this study was to investigate the anomeric composition of lactose powders after heating in a differential scanning calorimeter.
34048927	7	12	theme	%	924:924	arg1	β-anomer					926:933	29.7 ± 0.8% β-anomer	914:933	29.7 ± 0.8% β-anomer (p < 0.05)	914:944	When held at 160 °C for 60 min this increased to 29.7 ± 0.8% β-anomer (p < 0.05).
34048927	7	12	theme	%	924:924	arg1	p < 0.05					936:943	p < 0.05	936:943	p < 0.05	936:943	When held at 160 °C for 60 min this increased to 29.7 ± 0.8% β-anomer (p < 0.05).
34048927	2	13	theme	lactose	269:275	arg1	composition					254:264	the chiral composition	243:264	the chiral composition of lactose	243:275	Despite the assumption of chemical stability, in aqueous solution, the chiral composition of lactose is prone to change.
34048927	2	13	theme	lactose	269:275	arg1	prone					280:284	prone	280:284	prone	280:284	Despite the assumption of chemical stability, in aqueous solution, the chiral composition of lactose is prone to change.
34048927	4	14	theme	differential	550:561	arg1	calorimeter					572:582	a differential scanning calorimeter	548:582	a differential scanning calorimeter	548:582	Thus, the aim of this study was to investigate the anomeric composition of lactose powders after heating in a differential scanning calorimeter.
34048927	5	15	theme	thermal	592:598	arg1	analysis					600:607	thermal analysis	592:607	thermal analysis	592:607	During thermal analysis, the heating cycles were interrupted to allow anomer-composition analysis by NMR.
34048927	1	16	theme	solid	159:163	arg1	medicines					165:173	all solid medicines	155:173	all solid medicines	155:173	Lactose is present as an excipient in nearly half of all solid medicines.
34048927	3	17	theme	such	321:324	arg1	epimerisation					326:338	such epimerisation	321:338	such epimerisation	321:338	It is not known whether such epimerisation could also occur as solid crystalline α-lactose undergoes thermal desorption of its hydrated water.
34048927	1	18	from	excipient	127:135	arg1	half					147:150	nearly half	140:150	nearly half of all solid medicines	140:173	Lactose is present as an excipient in nearly half of all solid medicines.
34048927	13	19	theme	first	1705:1709	arg1	time					1711:1714	the first time	1701:1714	the first time	1701:1714	In summary, it has been shown unequivocally for the first time that hydrate desorption (dehydration) leads to solid-state epimerisation in α-lactose powders.
34048927	1	20	theme	medicines	165:173	arg1	half					147:150	nearly half	140:150	nearly half of all solid medicines	140:173	Lactose is present as an excipient in nearly half of all solid medicines.
34048927	13	21	theme	solid-state	1763:1773	arg1	epimerisation					1775:1787	solid-state epimerisation	1763:1787	solid-state epimerisation in α-lactose powders	1763:1808	In summary, it has been shown unequivocally for the first time that hydrate desorption (dehydration) leads to solid-state epimerisation in α-lactose powders.
34048927	8	22	theme	rate	1020:1023	arg1	constant					1025:1032	a rate constant	1018:1032	a rate constant of 0.28% per min-1	1018:1051	This process of epimerisation was found to be close to zero-order with a rate constant of 0.28% per min-1.
34048927	7	23	theme	29.7 ± 0.8	914:923	arg1	%					924:924	%	924:924	%	924:924	When held at 160 °C for 60 min this increased to 29.7 ± 0.8% β-anomer (p < 0.05).
34048927	12	24	theme	β-lactose	1622:1630	arg1	powders					1632:1638	β-lactose powders	1622:1638	β-lactose powders	1622:1638	No epimerisation or hydrate loss was observed for β-lactose powders when heated.
34048927	3	25	theme	solid	360:364	arg1	α-lactose					378:386	solid crystalline α-lactose	360:386	solid crystalline α-lactose	360:386	It is not known whether such epimerisation could also occur as solid crystalline α-lactose undergoes thermal desorption of its hydrated water.
34048927	4	26	theme	powders	523:529	arg1	composition					500:510	the anomeric composition	487:510	the anomeric composition of lactose powders	487:529	Thus, the aim of this study was to investigate the anomeric composition of lactose powders after heating in a differential scanning calorimeter.
34048927	5	27	theme	heating	614:620	arg1	cycles					622:627	the heating cycles	610:627	the heating cycles	610:627	During thermal analysis, the heating cycles were interrupted to allow anomer-composition analysis by NMR.
34048927	12	28	theme	hydrate	1592:1598	arg1	loss					1600:1603	hydrate loss	1592:1603	hydrate loss	1592:1603	No epimerisation or hydrate loss was observed for β-lactose powders when heated.
34048927	0	29	theme	monohydrate	23:33	arg1	Stability					0:8	Stability	0:8	Stability of α-lactose monohydrate	0:33	Stability of α-lactose monohydrate: The discovery of dehydration triggered solid-state epimerization.
34048927	4	30	theme	lactose	515:521	arg1	powders					523:529	lactose powders	515:529	lactose powders	515:529	Thus, the aim of this study was to investigate the anomeric composition of lactose powders after heating in a differential scanning calorimeter.
34048927	2	31	from	solution	233:240	arg1	composition					254:264	the chiral composition	243:264	the chiral composition of lactose	243:275	Despite the assumption of chemical stability, in aqueous solution, the chiral composition of lactose is prone to change.
34048927	2	31	from	solution	233:240	arg1	prone					280:284	prone	280:284	prone	280:284	Despite the assumption of chemical stability, in aqueous solution, the chiral composition of lactose is prone to change.
34048927	0	32	theme	α-lactose	13:21	arg1	monohydrate					23:33	α-lactose monohydrate	13:33	α-lactose monohydrate	13:33	Stability of α-lactose monohydrate: The discovery of dehydration triggered solid-state epimerization.
34048927	10	33	theme	Similar	1289:1295	arg1	results					1297:1303	Similar results	1289:1303	Similar results	1289:1303	Similar results were observed when heating α-lactose to 190 °C, which resulted in a conversion of 29.1 ± 0.7% to β-lactose.
34048927	9	34	theme	Optical	1054:1060	arg1	microscopy					1062:1071	Optical microscopy	1054:1071	Optical microscopy	1054:1071	Optical microscopy indicated that the solid-state was maintained throughout thermal desorption and up to the onset of melting at 214.2 ± 0.9 °C. Only epimerisation was observed, with no additional chemical degradation detected by NMR.
34048927	13	35	theme	α-lactose	1792:1800	arg1	powders					1802:1808	α-lactose powders	1792:1808	α-lactose powders	1792:1808	In summary, it has been shown unequivocally for the first time that hydrate desorption (dehydration) leads to solid-state epimerisation in α-lactose powders.
34048927	12	36	theme	No	1572:1573	arg1	epimerisation					1575:1587	No epimerisation	1572:1587	No epimerisation	1572:1587	No epimerisation or hydrate loss was observed for β-lactose powders when heated.
34048927	8	37	theme	%	1041:1041	arg1	constant					1025:1032	a rate constant	1018:1032	a rate constant of 0.28% per min-1	1018:1051	This process of epimerisation was found to be close to zero-order with a rate constant of 0.28% per min-1.
34048927	2	38	theme	aqueous	225:231	arg1	solution					233:240	aqueous solution	225:240	aqueous solution	225:240	Despite the assumption of chemical stability, in aqueous solution, the chiral composition of lactose is prone to change.
34048927	8	39	with	zero-order	1002:1011	arg1	constant					1025:1032	a rate constant	1018:1032	a rate constant of 0.28% per min-1	1018:1051	This process of epimerisation was found to be close to zero-order with a rate constant of 0.28% per min-1.
34048927	3	40	theme	water	433:437	arg1	desorption					406:415	thermal desorption	398:415	thermal desorption of its hydrated water	398:437	It is not known whether such epimerisation could also occur as solid crystalline α-lactose undergoes thermal desorption of its hydrated water.
34048927	3	41	theme	thermal	398:404	arg1	desorption					406:415	thermal desorption	398:415	thermal desorption of its hydrated water	398:437	It is not known whether such epimerisation could also occur as solid crystalline α-lactose undergoes thermal desorption of its hydrated water.
34048927	4	42	theme	anomeric	491:498	arg1	composition					500:510	the anomeric composition	487:510	the anomeric composition of lactose powders	487:529	Thus, the aim of this study was to investigate the anomeric composition of lactose powders after heating in a differential scanning calorimeter.
34048927	9	43	theme	214.2 ± 0.9 °C.	1183:1197	arg1	epimerisation					1204:1216	214.2 ± 0.9 °C. Only epimerisation	1183:1216	214.2 ± 0.9 °C. Only epimerisation	1183:1216	Optical microscopy indicated that the solid-state was maintained throughout thermal desorption and up to the onset of melting at 214.2 ± 0.9 °C. Only epimerisation was observed, with no additional chemical degradation detected by NMR.
34048927	3	44	theme	crystalline	366:376	arg1	α-lactose					378:386	solid crystalline α-lactose	360:386	solid crystalline α-lactose	360:386	It is not known whether such epimerisation could also occur as solid crystalline α-lactose undergoes thermal desorption of its hydrated water.
34048927	9	45	theme	Only	1199:1202	arg1	epimerisation					1204:1216	214.2 ± 0.9 °C. Only epimerisation	1183:1216	214.2 ± 0.9 °C. Only epimerisation	1183:1216	Optical microscopy indicated that the solid-state was maintained throughout thermal desorption and up to the onset of melting at 214.2 ± 0.9 °C. Only epimerisation was observed, with no additional chemical degradation detected by NMR.
34048927	13	46	from	epimerisation	1775:1787	arg1	powders					1802:1808	α-lactose powders	1792:1808	α-lactose powders	1792:1808	In summary, it has been shown unequivocally for the first time that hydrate desorption (dehydration) leads to solid-state epimerisation in α-lactose powders.
34048927	6	47	theme	Post	756:759	arg1	water-loss					761:770	143.8 ± 0.3 °C. Post water-loss	740:770	143.8 ± 0.3 °C. Post water-loss	740:770	The onset for monohydrate desorption occurred at 143.8 ± 0.3 °C. Post water-loss, at 160 °C for example, α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer.
34048927	9	48	theme	thermal	1130:1136	arg1	desorption					1138:1147	thermal desorption	1130:1147	thermal desorption	1130:1147	Optical microscopy indicated that the solid-state was maintained throughout thermal desorption and up to the onset of melting at 214.2 ± 0.9 °C. Only epimerisation was observed, with no additional chemical degradation detected by NMR.
34048927	5	49	theme	anomer-composition	655:672	arg1	analysis					674:681	anomer-composition analysis	655:681	anomer-composition analysis	655:681	During thermal analysis, the heating cycles were interrupted to allow anomer-composition analysis by NMR.
34048927	2	50	theme	chemical	202:209	arg1	stability					211:219	chemical stability	202:219	chemical stability	202:219	Despite the assumption of chemical stability, in aqueous solution, the chiral composition of lactose is prone to change.
34048927	2	51	theme	stability	211:219	arg1	assumption					188:197	the assumption	184:197	the assumption of chemical stability	184:219	Despite the assumption of chemical stability, in aqueous solution, the chiral composition of lactose is prone to change.
34048927	6	52	theme	143.8 ± 0.3 °C.	740:754	arg1	water-loss					761:770	143.8 ± 0.3 °C. Post water-loss	740:770	143.8 ± 0.3 °C. Post water-loss	740:770	The onset for monohydrate desorption occurred at 143.8 ± 0.3 °C. Post water-loss, at 160 °C for example, α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer.
34048927	8	53	theme	epimerisation	963:975	arg1	process					952:958	This process	947:958	This process of epimerisation	947:975	This process of epimerisation was found to be close to zero-order with a rate constant of 0.28% per min-1.
34048927	2	54	theme	chiral	247:252	arg1	composition					254:264	the chiral composition	243:264	the chiral composition of lactose	243:275	Despite the assumption of chemical stability, in aqueous solution, the chiral composition of lactose is prone to change.
34048927	2	54	theme	chiral	247:252	arg1	prone					280:284	prone	280:284	prone	280:284	Despite the assumption of chemical stability, in aqueous solution, the chiral composition of lactose is prone to change.
34048927	6	55	theme	partial	815:821	arg1	160 °C					776:781	160 °C	776:781	160 °C	776:781	The onset for monohydrate desorption occurred at 143.8 ± 0.3 °C. Post water-loss, at 160 °C for example, α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer.
34048927	6	55	theme	partial	815:821	arg1	conversion					823:832	α-lactose suffered partial conversion	796:832	α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer	796:862	The onset for monohydrate desorption occurred at 143.8 ± 0.3 °C. Post water-loss, at 160 °C for example, α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer.
34048927	6	55	theme	partial	815:821	arg1	%					845:845	11.6 ± 0.9%	835:845	11.6 ± 0.9%	835:845	The onset for monohydrate desorption occurred at 143.8 ± 0.3 °C. Post water-loss, at 160 °C for example, α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer.
34048927	3	56	theme	hydrated	424:431	arg1	water					433:437	its hydrated water	420:437	its hydrated water	420:437	It is not known whether such epimerisation could also occur as solid crystalline α-lactose undergoes thermal desorption of its hydrated water.
34048927	0	57	theme	dehydration	53:63	arg1	discovery					40:48	The discovery	36:48	The discovery of dehydration	36:63	Stability of α-lactose monohydrate: The discovery of dehydration triggered solid-state epimerization.
34048927	11	58	from	epimerisation	1557:1569	arg1	contribution					1539:1550	a contribution	1537:1550	a contribution from epimerisation	1537:1569	Thus, the exothermic peak observed after monohydrate loss, which has often been attributed to re-crystallisation, comprises a contribution from epimerisation.
34048927	6	59	theme	monohydrate	705:715	arg1	desorption					717:726	monohydrate desorption	705:726	monohydrate desorption	705:726	The onset for monohydrate desorption occurred at 143.8 ± 0.3 °C. Post water-loss, at 160 °C for example, α-lactose suffered partial conversion (11.6 ± 0.9%) to the β-anomer.
34048927	9	60	dep	onset	1163:1167	arg1	up					1153:1154	up	1153:1154	up	1153:1154	Optical microscopy indicated that the solid-state was maintained throughout thermal desorption and up to the onset of melting at 214.2 ± 0.9 °C. Only epimerisation was observed, with no additional chemical degradation detected by NMR.
32497185	2	0	theme	Saccharomyces	563:575	arg1	product					594:600	a Saccharomyces cerevisiae-based product	561:600	a Saccharomyces cerevisiae-based product	561:600	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	7	1	theme	Fusobacteriaceae	1733:1748	arg1	families					1750:1757	the Enterobacteriaceae and the Fusobacteriaceae families	1702:1757	the Enterobacteriaceae and the Fusobacteriaceae families	1702:1757	Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens.
32497185	5	2	theme	distal	1301:1306	arg1	colon					1308:1312	the simulated proximal and distal colon	1274:1312	the simulated proximal and distal colon	1274:1312	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	0	3	from	mannan-oligosaccharides	47:69	arg1	high					23:26	high	23:26	high	23:26	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro.
32497185	1	4	theme	mannan-oligosaccharides	249:271	arg1	levels					225:230	high levels	220:230	high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs	220:372	The outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs.
32497185	6	5	attach	linked	1375:1380	arg2	changes					1321:1327	These changes	1315:1327	These changes in terms of fermentative metabolites	1315:1364	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	6	5	attach	linked	1375:1380	arg1	stimulation					1458:1468	the specific stimulation	1445:1468	the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product	1445:1601	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	6	5	attach	linked	1375:1380	arg1	alterations					1404:1414	specific microbial alterations	1385:1414	specific microbial alterations	1385:1414	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	2	6	theme	Illumina	766:773	arg1	sequencing					775:784	16S-targeted Illumina sequencing	753:784	16S-targeted Illumina sequencing	753:784	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	6	7	theme	family	1423:1428	arg1	level					1430:1434	the family level	1419:1434	the family level	1419:1434	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	7	8	from	changes	1621:1627	arg1	composition					1642:1652	community composition	1632:1652	community composition	1632:1652	Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens.
32497185	2	9	theme	fermentative	695:706	arg1	metabolites					708:718	fermentative metabolites	695:718	fermentative metabolites	695:718	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	1	10	theme	cell	181:184	arg1	wall					186:189	The outer cell wall	171:189	The outer cell wall of yeast	171:198	The outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs.
32497185	2	11	theme	product	594:600	arg1	effect					551:556	the effect	547:556	the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota	547:817	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	5	12	theme	proximal	1288:1295	arg1	colon					1308:1312	the simulated proximal and distal colon	1274:1312	the simulated proximal and distal colon	1274:1312	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	6	13	theme	microbial	1394:1402	arg1	stimulation					1458:1468	the specific stimulation	1445:1468	the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product	1445:1601	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	6	13	theme	microbial	1394:1402	arg1	alterations					1404:1414	specific microbial alterations	1385:1414	specific microbial alterations	1385:1414	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	0	14	theme	gastrointestinal	138:153	arg1	tract					155:159	the canine gastrointestinal tract	127:159	the canine gastrointestinal tract	127:159	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro.
32497185	6	15	theme	S.	1575:1576	arg1	product					1595:1601	the S. cerevisiae-based product	1571:1601	the S. cerevisiae-based product	1571:1601	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	8	16	theme	health-promoting	1874:1889	arg1	role					1891:1894	a possible health-promoting role	1863:1894	a possible health-promoting role of a product high in β-glucans and MOS	1863:1933	Altogether, the generated data support a possible health-promoting role of a product high in β-glucans and MOS when supplemented to the dogs' diet.
32497185	6	17	theme	specific	1449:1456	arg1	stimulation					1458:1468	the specific stimulation	1445:1468	the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product	1445:1601	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	0	18	from	activity	115:122	arg1	tract					155:159	the canine gastrointestinal tract	127:159	the canine gastrointestinal tract	127:159	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro.
32497185	2	19	used	used	530:533	arg2	simulation					414:423	a standardized in vitro simulation	390:423	a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME)	390:524	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	7	20	theme	community	1632:1640	arg1	composition					1642:1652	community composition	1632:1652	community composition	1632:1652	Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens.
32497185	0	21	from	composition	99:109	arg1	tract					155:159	the canine gastrointestinal tract	127:159	the canine gastrointestinal tract	127:159	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro.
32497185	4	22	theme	acetate	1068:1074	arg1	production					1035:1044	the increased production	1021:1044	the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d)	1021:1160	A dose-dependent fermentation pattern was observed along the entire length of the colon, as shown by the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d).
32497185	8	23	theme	product	1901:1907	arg1	role					1891:1894	a possible health-promoting role	1863:1894	a possible health-promoting role of a product high in β-glucans and MOS	1863:1933	Altogether, the generated data support a possible health-promoting role of a product high in β-glucans and MOS when supplemented to the dogs' diet.
32497185	6	24	from	level	1430:1434	arg1	stimulation					1458:1468	the specific stimulation	1445:1468	the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product	1445:1601	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	6	24	from	level	1430:1434	arg1	alterations					1404:1414	specific microbial alterations	1385:1414	specific microbial alterations	1385:1414	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	3	25	theme	cerevisiae-based	827:842	arg1	product					844:850	The S. cerevisiae-based product	820:850	The S. cerevisiae-based product	820:850	The S. cerevisiae-based product was tested at three different dosages, i.e., 0.5, 1.0, and 2.0 g/d.
32497185	4	26	theme	propionate	1077:1086	arg1	production					1035:1044	the increased production	1021:1044	the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d)	1021:1160	A dose-dependent fermentation pattern was observed along the entire length of the colon, as shown by the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d).
32497185	1	27	theme	intestinal	330:339	arg1	health					341:346	intestinal health	330:346	intestinal health	330:346	The outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs.
32497185	6	28	theme	in	1550:1551	arg1	exposure					1559:1566	in vitro exposure	1550:1566	in vitro exposure to the S. cerevisiae-based product	1550:1601	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	7	29	theme	Other	1604:1608	arg1	changes					1621:1627	Other consistent changes	1604:1627	Other consistent changes in community composition upon repeated exposure	1604:1675	Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens.
32497185	2	30	theme	Ecosystem	508:516	arg1	Simulator					463:471	Simulator	463:471	Simulator of the Canine Intestinal Microbial Ecosystem; SCIME	463:523	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	2	30	theme	Ecosystem	508:516	arg1	tract					456:460	the canine gastrointestinal tract	428:460	the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME)	428:524	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	2	31	theme	%	621:621	arg1	MOS					643:645	27.5% β-glucans and 22.5% MOS	617:645	27.5% β-glucans and 22.5% MOS	617:645	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	2	32	dep	activity	655:662	arg1	assessed					668:675	assessed	668:675	assessed by measurement of fermentative metabolites	668:718	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	2	33	theme	Intestinal	487:496	arg1	Ecosystem					508:516	the Canine Intestinal Microbial Ecosystem	476:516	the Canine Intestinal Microbial Ecosystem	476:516	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	0	34	from	beta-glucan	31:41	arg1	high					23:26	high	23:26	high	23:26	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro.
32497185	2	35	dep	in	405:406	arg1	vitro					408:412	vitro	408:412	vitro	408:412	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	0	36	from	high	23:26	arg1	mannan-oligosaccharides					47:69	mannan-oligosaccharides	47:69	mannan-oligosaccharides	47:69	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro.
32497185	0	36	from	high	23:26	arg1	beta-glucan					31:41	beta-glucan	31:41	beta-glucan	31:41	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro.
32497185	2	37	theme	%	641:641	arg1	MOS					643:645	27.5% β-glucans and 22.5% MOS	617:645	27.5% β-glucans and 22.5% MOS	617:645	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	5	38	theme	increased	1228:1236	arg1	production					1249:1258	the increased propionate production	1224:1258	the increased propionate production (P < 0.05)	1224:1269	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	5	38	theme	increased	1228:1236	arg1	<					1263:1263	P < 0.05	1261:1268	P < 0.05	1261:1268	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	5	38	theme	increased	1228:1236	arg1	finding					1176:1182	A consistent finding	1163:1182	A consistent finding for all three tested concentrations	1163:1218	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	0	39	theme	Dried	0:4	arg1	walls					17:21	Dried yeast cell walls	0:21	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides	0:69	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro.
32497185	6	40	theme	propionate-producing	1477:1496	arg1	families					1498:1505	the propionate-producing families	1473:1505	the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product	1473:1601	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	6	40	theme	propionate-producing	1477:1496	arg1	Prevotellaceae					1530:1543	Prevotellaceae	1530:1543	Prevotellaceae	1530:1543	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	6	40	theme	propionate-producing	1477:1496	arg1	Porphyromonadaceae					1507:1524	Porphyromonadaceae	1507:1524	Porphyromonadaceae	1507:1524	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	5	41	from	production	1249:1258	arg1	colon					1308:1312	the simulated proximal and distal colon	1274:1312	the simulated proximal and distal colon	1274:1312	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	2	42	from	effect	551:556	arg1	activity					655:662	the activity	651:662	the activity (as assessed by measurement of fermentative metabolites)	651:719	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	2	42	from	effect	551:556	arg1	composition					725:735	composition	725:735	composition (as assessed by 16S-targeted Illumina sequencing)	725:785	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	2	43	theme	standardized	392:403	arg1	simulation					414:423	a standardized in vitro simulation	390:423	a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME)	390:524	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	0	44	theme	cell	12:15	arg1	walls					17:21	Dried yeast cell walls	0:21	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides	0:69	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro.
32497185	3	45	theme	different	872:880	arg1	dosages					882:888	three different dosages	866:888	three different dosages	866:888	The S. cerevisiae-based product was tested at three different dosages, i.e., 0.5, 1.0, and 2.0 g/d.
32497185	2	46	theme	tract	456:460	arg1	simulation					414:423	a standardized in vitro simulation	390:423	a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME)	390:524	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	5	47	theme	tested	1198:1203	arg1	concentrations					1205:1218	all three tested concentrations	1188:1218	all three tested concentrations	1188:1218	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	1	48	from	health	341:346	arg1	dogs					369:372	dogs	369:372	dogs	369:372	The outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs.
32497185	0	49	theme	high	23:26	arg1	walls					17:21	Dried yeast cell walls	0:21	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides	0:69	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro.
32497185	4	50	theme	fermentation	937:948	arg1	pattern					950:956	A dose-dependent fermentation pattern	920:956	A dose-dependent fermentation pattern	920:956	A dose-dependent fermentation pattern was observed along the entire length of the colon, as shown by the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d).
32497185	2	51	theme	16S-targeted	753:764	arg1	sequencing					775:784	16S-targeted Illumina sequencing	753:784	16S-targeted Illumina sequencing	753:784	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	4	52	dep	tested	1131:1136	arg1	g/d					1157:1159	0.5, 1.0, and 2.0 g/d	1139:1159	0.5, 1.0, and 2.0 g/d	1139:1159	A dose-dependent fermentation pattern was observed along the entire length of the colon, as shown by the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d).
32497185	4	52	dep	tested	1131:1136	arg1	concentrations					1116:1129	the three concentrations	1106:1129	the three concentrations tested (0.5, 1.0, and 2.0 g/d)	1106:1160	A dose-dependent fermentation pattern was observed along the entire length of the colon, as shown by the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d).
32497185	1	53	theme	high	220:223	arg1	levels					225:230	high levels	220:230	high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs	220:372	The outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs.
32497185	7	54	theme	opportunistic	1799:1811	arg1	pathogens					1813:1821	potentially opportunistic pathogens	1787:1821	several potentially opportunistic pathogens	1779:1821	Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens.
32497185	6	55	from	changes	1321:1327	arg1	terms					1332:1336	terms	1332:1336	terms of fermentative metabolites	1332:1364	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	7	56	from	decrease	1690:1697	arg1	families					1750:1757	the Enterobacteriaceae and the Fusobacteriaceae families	1702:1757	the Enterobacteriaceae and the Fusobacteriaceae families	1702:1757	Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens.
32497185	2	57	theme	microbiota	808:817	arg1	activity					655:662	the activity	651:662	the activity (as assessed by measurement of fermentative metabolites)	651:719	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	2	57	theme	microbiota	808:817	arg1	composition					725:735	composition	725:735	composition (as assessed by 16S-targeted Illumina sequencing)	725:785	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	6	58	theme	fermentative	1341:1352	arg1	metabolites					1354:1364	fermentative metabolites	1341:1364	fermentative metabolites	1341:1364	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	2	59	theme	canine	432:437	arg1	Simulator					463:471	Simulator	463:471	Simulator of the Canine Intestinal Microbial Ecosystem; SCIME	463:523	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	2	59	theme	canine	432:437	arg1	tract					456:460	the canine gastrointestinal tract	428:460	the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME)	428:524	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	4	60	theme	entire	981:986	arg1	length					988:993	the entire length	977:993	the entire length of the colon	977:1006	A dose-dependent fermentation pattern was observed along the entire length of the colon, as shown by the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d).
32497185	2	61	theme	canine	790:795	arg1	microbiota					808:817	canine intestinal microbiota	790:817	canine intestinal microbiota	790:817	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	5	62	theme	P	1261:1261	arg1	production					1249:1258	the increased propionate production	1224:1258	the increased propionate production (P < 0.05)	1224:1269	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	5	62	theme	P	1261:1261	arg1	<					1263:1263	P < 0.05	1261:1268	P < 0.05	1261:1268	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	7	63	theme	Enterobacteriaceae	1706:1723	arg1	families					1750:1757	the Enterobacteriaceae and the Fusobacteriaceae families	1702:1757	the Enterobacteriaceae and the Fusobacteriaceae families	1702:1757	Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens.
32497185	2	64	theme	metabolites	708:718	arg1	measurement					680:690	measurement	680:690	measurement of fermentative metabolites	680:718	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	1	65	theme	outer	175:179	arg1	wall					186:189	The outer cell wall	171:189	The outer cell wall of yeast	171:198	The outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs.
32497185	2	66	dep	assessed	741:748	arg1	as					738:739	as	738:739	as	738:739	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	4	67	theme	health-related	1053:1066	arg1	acetate					1068:1074	the health-related acetate	1049:1074	the health-related acetate	1049:1074	A dose-dependent fermentation pattern was observed along the entire length of the colon, as shown by the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d).
32497185	8	68	theme	generated	1840:1848	arg1	data					1850:1853	the generated data	1836:1853	the generated data	1836:1853	Altogether, the generated data support a possible health-promoting role of a product high in β-glucans and MOS when supplemented to the dogs' diet.
32497185	5	69	theme	simulated	1278:1286	arg1	colon					1308:1312	the simulated proximal and distal colon	1274:1312	the simulated proximal and distal colon	1274:1312	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	2	70	theme	cerevisiae-based	577:592	arg1	product					594:600	a Saccharomyces cerevisiae-based product	561:600	a Saccharomyces cerevisiae-based product	561:600	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	0	71	theme	canine	131:136	arg1	tract					155:159	the canine gastrointestinal tract	127:159	the canine gastrointestinal tract	127:159	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro.
32497185	6	72	theme	specific	1385:1392	arg1	stimulation					1458:1468	the specific stimulation	1445:1468	the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product	1445:1601	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	6	72	theme	specific	1385:1392	arg1	alterations					1404:1414	specific microbial alterations	1385:1414	specific microbial alterations	1385:1414	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	1	73	theme	yeast	194:198	arg1	wall					186:189	The outer cell wall	171:189	The outer cell wall of yeast	171:198	The outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs.
32497185	8	74	from	β-glucans	1917:1925	arg1	high					1909:1912	high	1909:1912	high	1909:1912	Altogether, the generated data support a possible health-promoting role of a product high in β-glucans and MOS when supplemented to the dogs' diet.
32497185	4	75	theme	increased	1025:1033	arg1	production					1035:1044	the increased production	1021:1044	the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d)	1021:1160	A dose-dependent fermentation pattern was observed along the entire length of the colon, as shown by the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d).
32497185	8	76	theme	possible	1865:1872	arg1	role					1891:1894	a possible health-promoting role	1863:1894	a possible health-promoting role of a product high in β-glucans and MOS	1863:1933	Altogether, the generated data support a possible health-promoting role of a product high in β-glucans and MOS when supplemented to the dogs' diet.
32497185	3	77	dep	g/d	915:917	arg1	i.e.					891:894	i.e.	891:894	i.e.	891:894	The S. cerevisiae-based product was tested at three different dosages, i.e., 0.5, 1.0, and 2.0 g/d.
32497185	4	78	theme	colon	1002:1006	arg1	length					988:993	the entire length	977:993	the entire length of the colon	977:1006	A dose-dependent fermentation pattern was observed along the entire length of the colon, as shown by the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d).
32497185	6	79	theme	cerevisiae-based	1578:1593	arg1	product					1595:1601	the S. cerevisiae-based product	1571:1601	the S. cerevisiae-based product	1571:1601	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	4	80	theme	butyrate	1093:1100	arg1	production					1035:1044	the increased production	1021:1044	the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d)	1021:1160	A dose-dependent fermentation pattern was observed along the entire length of the colon, as shown by the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d).
32497185	6	81	dep	in	1550:1551	arg1	vitro					1553:1557	vitro	1553:1557	vitro	1553:1557	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	7	82	theme	repeated	1659:1666	arg1	exposure					1668:1675	repeated exposure	1659:1675	repeated exposure	1659:1675	Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens.
32497185	8	83	from	MOS	1931:1933	arg1	high					1909:1912	high	1909:1912	high	1909:1912	Altogether, the generated data support a possible health-promoting role of a product high in β-glucans and MOS when supplemented to the dogs' diet.
32497185	5	84	theme	consistent	1165:1174	arg1	production					1249:1258	the increased propionate production	1224:1258	the increased propionate production (P < 0.05)	1224:1269	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	5	84	theme	consistent	1165:1174	arg1	finding					1176:1182	A consistent finding	1163:1182	A consistent finding for all three tested concentrations	1163:1218	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	8	85	theme	high	1909:1912	arg1	product					1901:1907	a product	1899:1907	a product high in β-glucans and MOS	1899:1933	Altogether, the generated data support a possible health-promoting role of a product high in β-glucans and MOS when supplemented to the dogs' diet.
32497185	7	86	theme	consistent	1610:1619	arg1	changes					1621:1627	Other consistent changes	1604:1627	Other consistent changes in community composition upon repeated exposure	1604:1675	Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens.
32497185	0	87	theme	microbial	89:97	arg1	composition					99:109	microbial composition	89:109	microbial composition	89:109	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro.
32497185	2	88	theme	β-glucans	623:631	arg1	%					621:621	27.5% β-glucans	617:631	27.5% β-glucans	617:631	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	3	89	theme	S.	824:825	arg1	product					844:850	The S. cerevisiae-based product	820:850	The S. cerevisiae-based product	820:850	The S. cerevisiae-based product was tested at three different dosages, i.e., 0.5, 1.0, and 2.0 g/d.
32497185	2	90	theme	Microbial	498:506	arg1	Ecosystem					508:516	the Canine Intestinal Microbial Ecosystem	476:516	the Canine Intestinal Microbial Ecosystem	476:516	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	1	91	theme	immune	352:357	arg1	status					359:364	immune status	352:364	immune status	352:364	The outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs.
32497185	2	92	theme	Canine	480:485	arg1	Ecosystem					508:516	the Canine Intestinal Microbial Ecosystem	476:516	the Canine Intestinal Microbial Ecosystem	476:516	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	0	93	theme	yeast	6:10	arg1	walls					17:21	Dried yeast cell walls	0:21	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides	0:69	Dried yeast cell walls high in beta-glucan and mannan-oligosaccharides positively affect microbial composition and activity in the canine gastrointestinal tract in vitro.
32497185	6	94	theme	families	1498:1505	arg1	stimulation					1458:1468	the specific stimulation	1445:1468	the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product	1445:1601	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	6	95	dep	families	1498:1505	arg1	families					1498:1505	the propionate-producing families	1473:1505	the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product	1473:1601	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	6	95	dep	families	1498:1505	arg1	Prevotellaceae					1530:1543	Prevotellaceae	1530:1543	Prevotellaceae	1530:1543	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	6	95	dep	families	1498:1505	arg1	Porphyromonadaceae					1507:1524	Porphyromonadaceae	1507:1524	Porphyromonadaceae	1507:1524	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	2	96	theme	in	405:406	arg1	simulation					414:423	a standardized in vitro simulation	390:423	a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME)	390:524	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	2	97	theme	gastrointestinal	439:454	arg1	Simulator					463:471	Simulator	463:471	Simulator of the Canine Intestinal Microbial Ecosystem; SCIME	463:523	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	2	97	theme	gastrointestinal	439:454	arg1	tract					456:460	the canine gastrointestinal tract	428:460	the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME)	428:524	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	7	98	contain	contain	1771:1777	arg1	both					1766:1769	both	1766:1769	both	1766:1769	Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens.
32497185	7	98	contain	contain	1771:1777	arg2	decrease					1690:1697	the decrease	1686:1697	the decrease	1686:1697	Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens.
32497185	7	98	contain	contain	1771:1777	arg2	pathogens					1813:1821	potentially opportunistic pathogens	1787:1821	several potentially opportunistic pathogens	1779:1821	Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens.
32497185	1	99	from	effects	319:325	arg1	health					341:346	intestinal health	330:346	intestinal health	330:346	The outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs.
32497185	1	99	from	effects	319:325	arg1	status					359:364	immune status	352:364	immune status	352:364	The outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs.
32497185	2	100	dep	Simulator	463:471	arg1	SCIME					519:523	SCIME	519:523	Simulator of the Canine Intestinal Microbial Ecosystem; SCIME	463:523	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	7	101	theme	several	1779:1785	arg1	pathogens					1813:1821	potentially opportunistic pathogens	1787:1821	several potentially opportunistic pathogens	1779:1821	Other consistent changes in community composition upon repeated exposure included the decrease in the Enterobacteriaceae and the Fusobacteriaceae families, which both contain several potentially opportunistic pathogens.
32497185	4	102	theme	dose-dependent	922:935	arg1	pattern					950:956	A dose-dependent fermentation pattern	920:956	A dose-dependent fermentation pattern	920:956	A dose-dependent fermentation pattern was observed along the entire length of the colon, as shown by the increased production of the health-related acetate, propionate, and butyrate for the three concentrations tested (0.5, 1.0, and 2.0 g/d).
32497185	8	103	from	high	1909:1912	arg1	MOS					1931:1933	MOS	1931:1933	MOS	1931:1933	Altogether, the generated data support a possible health-promoting role of a product high in β-glucans and MOS when supplemented to the dogs' diet.
32497185	8	103	from	high	1909:1912	arg1	β-glucans					1917:1925	β-glucans	1917:1925	β-glucans	1917:1925	Altogether, the generated data support a possible health-promoting role of a product high in β-glucans and MOS when supplemented to the dogs' diet.
32497185	1	104	theme	beneficial	308:317	arg1	effects					319:325	beneficial effects	308:325	beneficial effects on intestinal health and immune status in dogs	308:372	The outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs.
32497185	2	105	dep	composition	725:735	arg1	assessed					741:748	assessed	741:748	assessed by 16S-targeted Illumina sequencing	741:784	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	5	106	theme	propionate	1238:1247	arg1	production					1249:1258	the increased propionate production	1224:1258	the increased propionate production (P < 0.05)	1224:1269	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	5	106	theme	propionate	1238:1247	arg1	<					1263:1263	P < 0.05	1261:1268	P < 0.05	1261:1268	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	5	106	theme	propionate	1238:1247	arg1	finding					1176:1182	A consistent finding	1163:1182	A consistent finding for all three tested concentrations	1163:1218	A consistent finding for all three tested concentrations was the increased propionate production (P < 0.05) in the simulated proximal and distal colon.
32497185	6	107	theme	metabolites	1354:1364	arg1	terms					1332:1336	terms	1332:1336	terms of fermentative metabolites	1332:1364	These changes in terms of fermentative metabolites could be linked to specific microbial alterations at the family level, such as the specific stimulation of the propionate-producing families Porphyromonadaceae and Prevotellaceae upon in vitro exposure to the S. cerevisiae-based product.
32497185	2	108	theme	intestinal	797:806	arg1	microbiota					808:817	canine intestinal microbiota	790:817	canine intestinal microbiota	790:817	In this study, a standardized in vitro simulation of the canine gastrointestinal tract (Simulator of the Canine Intestinal Microbial Ecosystem; SCIME) was used to evaluate the effect of a Saccharomyces cerevisiae-based product, consisting of 27.5% β-glucans and 22.5% MOS, on the activity (as assessed by measurement of fermentative metabolites) and composition (as assessed by 16S-targeted Illumina sequencing) of canine intestinal microbiota.
32497185	1	109	from	status	359:364	arg1	dogs					369:372	dogs	369:372	dogs	369:372	The outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs.
32497185	1	110	theme	β-glucans	235:243	arg1	levels					225:230	high levels	220:230	high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs	220:372	The outer cell wall of yeast is characterized by high levels of β-glucans and mannan-oligosaccharides (MOS), which have been linked with beneficial effects on intestinal health and immune status in dogs.
32560446	4	0	theme	products	1053:1060	arg1	performance					1030:1040	the environmental performance	1012:1040	the environmental performance of the two products	1012:1060	We compare the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite, to identify tradeoffs between the environmental performance of the two products.
32560446	3	1	theme	environmental	686:698	arg1	impacts					700:706	the main environmental impacts	677:706	the main environmental impacts that are generated during the production of the bio-based resin used in the biocomposite	677:795	We evaluate the main environmental impacts that are generated during the production of the bio-based resin used in the biocomposite, as well as the biocomposite itself.
32560446	6	2	theme	fossil	1294:1299	arg1	composite					1314:1322	the fossil fuel derived composite	1290:1322	the fossil fuel derived composite	1290:1322	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	5	3	theme	environmental	1205:1217	arg1	impacts					1219:1225	lower negative environmental impacts	1190:1225	lower negative environmental impacts	1190:1225	We demonstrate that the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin shows lower negative environmental impacts in most studied categories.
32560446	2	4	theme	flax-based	593:602	arg1	reinforcement					604:616	flax-based reinforcement	593:616	flax-based reinforcement using life cycle assessment (LCA) methodology	593:662	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	6	5	link	derived	1306:1312	arg1	composite					1314:1322	the fossil fuel derived composite	1290:1322	the fossil fuel derived composite	1290:1322	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	1	6	theme	life	178:181	arg1	cycle					183:187	their life cycle	172:187	their life cycle	172:187	Biocomposites can be both environmentally and economically beneficial: during their life cycle they generally use and generate less petroleum-based carbon, and when produced from the byproduct of another industry or recycled back to the manufacturing process, they will bring additional economic benefits through contributing to a circular economy.
32560446	4	7	theme	life	849:852	arg1	impacts					860:866	the life cycle impacts	845:866	the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite	845:979	We compare the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite, to identify tradeoffs between the environmental performance of the two products.
32560446	3	8	theme	bio-based	756:764	arg1	resin					766:770	the bio-based resin	752:770	the bio-based resin used in the biocomposite	752:795	We evaluate the main environmental impacts that are generated during the production of the bio-based resin used in the biocomposite, as well as the biocomposite itself.
32560446	4	9	theme	cycle	854:858	arg1	impacts					860:866	the life cycle impacts	845:866	the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite	845:979	We compare the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite, to identify tradeoffs between the environmental performance of the two products.
32560446	4	10	theme	similar	915:921	arg1	resin					939:943	a functionally similar petroleum-based resin	900:943	a functionally similar petroleum-based resin	900:943	We compare the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite, to identify tradeoffs between the environmental performance of the two products.
32560446	1	11	theme	additional	370:379	arg1	benefits					390:397	additional economic benefits	370:397	additional economic benefits	370:397	Biocomposites can be both environmentally and economically beneficial: during their life cycle they generally use and generate less petroleum-based carbon, and when produced from the byproduct of another industry or recycled back to the manufacturing process, they will bring additional economic benefits through contributing to a circular economy.
32560446	7	12	theme	bio-based	1648:1656	arg1	resin					1658:1662	the bio-based resin	1644:1662	the bio-based resin	1644:1662	For future designs, considering an alternative cross-linker to facilitate the bond between the bio-based resin and the flax fiber, may help improve the overall environmental performance of the biocomposite.
32560446	2	13	theme	oil-based	545:553	arg1	resin					555:559	a soybean oil-based resin	535:559	a soybean oil-based resin (epoxidized sucrose soyate)	535:587	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	2	13	theme	oil-based	545:553	arg1	soyate					581:586	epoxidized sucrose soyate	562:586	epoxidized sucrose soyate	562:586	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	9	14	theme	overall	1956:1962	arg1	footprint					1971:1979	a better overall carbon footprint	1947:1979	a better overall carbon footprint for the biocomposite compared to the BPA-based composite	1947:2036	The findings show a better overall carbon footprint for the biocomposite compared to the BPA-based composite at almost all times, demonstrating a good potential for marketability especially in the presence of incentives or regulations that address reducing the carbon intensity of products.
32560446	9	15	theme	products	2210:2217	arg1	intensity					2197:2205	the carbon intensity	2186:2205	the carbon intensity of products	2186:2217	The findings show a better overall carbon footprint for the biocomposite compared to the BPA-based composite at almost all times, demonstrating a good potential for marketability especially in the presence of incentives or regulations that address reducing the carbon intensity of products.
32560446	5	16	theme	bio-based	1087:1095	arg1	soyate					1123:1128	epoxidized sucrose soyate	1104:1128	epoxidized sucrose soyate	1104:1128	We demonstrate that the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin shows lower negative environmental impacts in most studied categories.
32560446	5	16	theme	bio-based	1087:1095	arg1	resin					1097:1101	the bio-based resin	1083:1101	the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin	1083:1182	We demonstrate that the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin shows lower negative environmental impacts in most studied categories.
32560446	4	17	theme	biocomposite	884:895	arg1	impacts					860:866	the life cycle impacts	845:866	the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite	845:979	We compare the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite, to identify tradeoffs between the environmental performance of the two products.
32560446	10	18	theme	supply	2288:2293	arg1	chain					2295:2299	the biocomposite's supply chain	2269:2299	the biocomposite's supply chain	2269:2299	This analysis allowed us to pinpoint hotspots in the biocomposite's supply chain and recommend future modifications to improve the product's sustainability.
32560446	2	19	theme	sucrose	573:579	arg1	resin					555:559	a soybean oil-based resin	535:559	a soybean oil-based resin (epoxidized sucrose soyate)	535:587	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	2	19	theme	sucrose	573:579	arg1	soyate					581:586	epoxidized sucrose soyate	562:586	epoxidized sucrose soyate	562:586	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	6	20	theme	derived	1306:1312	arg1	composite					1314:1322	the fossil fuel derived composite	1290:1322	the fossil fuel derived composite	1290:1322	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	7	21	theme	alternative	1588:1598	arg1	cross-linker					1600:1611	an alternative cross-linker	1585:1611	an alternative cross-linker to facilitate the bond between the bio-based resin and the flax fiber	1585:1681	For future designs, considering an alternative cross-linker to facilitate the bond between the bio-based resin and the flax fiber, may help improve the overall environmental performance of the biocomposite.
32560446	1	22	theme	manufacturing	331:343	arg1	process					345:351	the manufacturing process	327:351	the manufacturing process	327:351	Biocomposites can be both environmentally and economically beneficial: during their life cycle they generally use and generate less petroleum-based carbon, and when produced from the byproduct of another industry or recycled back to the manufacturing process, they will bring additional economic benefits through contributing to a circular economy.
32560446	7	23	theme	overall	1705:1711	arg1	performance					1727:1737	the overall environmental performance	1701:1737	the overall environmental performance of the biocomposite	1701:1757	For future designs, considering an alternative cross-linker to facilitate the bond between the bio-based resin and the flax fiber, may help improve the overall environmental performance of the biocomposite.
32560446	4	24	theme	flax	949:952	arg1	composite					971:979	flax fiber reinforced composite	949:979	flax fiber reinforced composite	949:979	We compare the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite, to identify tradeoffs between the environmental performance of the two products.
32560446	4	25	theme	reinforced	960:969	arg1	composite					971:979	flax fiber reinforced composite	949:979	flax fiber reinforced composite	949:979	We compare the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite, to identify tradeoffs between the environmental performance of the two products.
32560446	6	26	theme	epoxidized	1355:1364	arg1	soyate					1374:1379	epoxidized sucrose soyate	1355:1379	epoxidized sucrose soyate	1355:1379	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	5	27	theme	sucrose	1115:1121	arg1	soyate					1123:1128	epoxidized sucrose soyate	1104:1128	epoxidized sucrose soyate	1104:1128	We demonstrate that the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin shows lower negative environmental impacts in most studied categories.
32560446	5	27	theme	sucrose	1115:1121	arg1	resin					1097:1101	the bio-based resin	1083:1101	the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin	1083:1182	We demonstrate that the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin shows lower negative environmental impacts in most studied categories.
32560446	0	28	theme	Epoxidized	42:51	arg1	Soyate					61:66	Epoxidized Sucrose Soyate	42:66	Epoxidized Sucrose Soyate	42:66	A Preliminary Environmental Assessment of Epoxidized Sucrose Soyate (ESS)-Based Biocomposite.
32560446	8	29	theme	model	1846:1850	arg1	inputs					1852:1857	LCA model inputs	1842:1857	LCA model inputs	1842:1857	An uncertainty analysis was also performed to evaluate the effect of variation in LCA model inputs on the environmental results for both the biocomposite and composite.
32560446	0	30	theme	Environmental	14:26	arg1	Assessment					28:37	A Preliminary Environmental Assessment	0:37	A Preliminary Environmental Assessment of Epoxidized Sucrose Soyate (ESS)	0:72	A Preliminary Environmental Assessment of Epoxidized Sucrose Soyate (ESS)-Based Biocomposite.
32560446	0	30	theme	Environmental	14:26	arg1	ESS					69:71	ESS	69:71	ESS	69:71	A Preliminary Environmental Assessment of Epoxidized Sucrose Soyate (ESS)-Based Biocomposite.
32560446	9	31	theme	good	2075:2078	arg1	potential					2080:2088	a good potential	2073:2088	a good potential for marketability	2073:2106	The findings show a better overall carbon footprint for the biocomposite compared to the BPA-based composite at almost all times, demonstrating a good potential for marketability especially in the presence of incentives or regulations that address reducing the carbon intensity of products.
32560446	6	32	theme	-based	1407:1412	arg1	resin					1420:1424	epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin	1355:1424	epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin	1355:1424	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	1	33	theme	industry	298:305	arg1	byproduct					277:285	the byproduct	273:285	the byproduct of another industry	273:305	Biocomposites can be both environmentally and economically beneficial: during their life cycle they generally use and generate less petroleum-based carbon, and when produced from the byproduct of another industry or recycled back to the manufacturing process, they will bring additional economic benefits through contributing to a circular economy.
32560446	4	34	theme	environmental	1016:1028	arg1	performance					1030:1040	the environmental performance	1012:1040	the environmental performance of the two products	1012:1060	We compare the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite, to identify tradeoffs between the environmental performance of the two products.
32560446	5	35	theme	conventional	1145:1156	arg1	resin					1178:1182	a conventional (bisphenol A-based) resin	1143:1182	a conventional (bisphenol A-based) resin	1143:1182	We demonstrate that the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin shows lower negative environmental impacts in most studied categories.
32560446	0	36	theme	Sucrose	53:59	arg1	Soyate					61:66	Epoxidized Sucrose Soyate	42:66	Epoxidized Sucrose Soyate	42:66	A Preliminary Environmental Assessment of Epoxidized Sucrose Soyate (ESS)-Based Biocomposite.
32560446	5	37	theme	bisphenol	1159:1167	arg1	resin					1178:1182	a conventional (bisphenol A-based) resin	1143:1182	a conventional (bisphenol A-based) resin	1143:1182	We demonstrate that the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin shows lower negative environmental impacts in most studied categories.
32560446	3	38	theme	main	681:684	arg1	impacts					700:706	the main environmental impacts	677:706	the main environmental impacts that are generated during the production of the bio-based resin used in the biocomposite	677:795	We evaluate the main environmental impacts that are generated during the production of the bio-based resin used in the biocomposite, as well as the biocomposite itself.
32560446	6	39	theme	most	1488:1491	arg1	categories					1493:1502	most categories	1488:1502	most categories except eutrophication and ozone layer depletion	1488:1550	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	10	40	from	hotspots	2257:2264	arg1	chain					2295:2299	the biocomposite's supply chain	2269:2299	the biocomposite's supply chain	2269:2299	This analysis allowed us to pinpoint hotspots in the biocomposite's supply chain and recommend future modifications to improve the product's sustainability.
32560446	6	41	theme	composite	1475:1483	arg1	performance					1456:1466	the environmental performance	1438:1466	the environmental performance of the composite in most categories except eutrophication and ozone layer depletion	1438:1550	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	8	42	theme	environmental	1866:1878	arg1	results					1880:1886	the environmental results	1862:1886	the environmental results for both the biocomposite and composite	1862:1926	An uncertainty analysis was also performed to evaluate the effect of variation in LCA model inputs on the environmental results for both the biocomposite and composite.
32560446	6	43	theme	fuel	1301:1304	arg1	composite					1314:1322	the fossil fuel derived composite	1290:1322	the fossil fuel derived composite	1290:1322	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	5	44	theme	negative	1196:1203	arg1	impacts					1219:1225	lower negative environmental impacts	1190:1225	lower negative environmental impacts	1190:1225	We demonstrate that the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin shows lower negative environmental impacts in most studied categories.
32560446	2	45	theme	cycle	629:633	arg1	LCA					647:649	LCA	647:649	LCA	647:649	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	2	45	theme	cycle	629:633	arg1	assessment					635:644	life cycle assessment	624:644	life cycle assessment (LCA) methodology	624:662	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	6	46	dep	eutrophication	1511:1524	arg1	depletion					1542:1550	layer depletion	1536:1550	layer depletion	1536:1550	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	6	47	theme	environmental	1442:1454	arg1	performance					1456:1466	the environmental performance	1438:1466	the environmental performance of the composite in most categories except eutrophication and ozone layer depletion	1438:1550	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	2	48	theme	assessment	635:644	arg1	methodology					652:662	life cycle assessment (LCA) methodology	624:662	life cycle assessment (LCA) methodology	624:662	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	6	49	theme	layer	1536:1540	arg1	depletion					1542:1550	layer depletion	1536:1550	layer depletion	1536:1550	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	9	50	dep	incentives	2138:2147	arg1	presence					2126:2133	presence	2126:2133	presence	2126:2133	The findings show a better overall carbon footprint for the biocomposite compared to the BPA-based composite at almost all times, demonstrating a good potential for marketability especially in the presence of incentives or regulations that address reducing the carbon intensity of products.
32560446	9	50	dep	incentives	2138:2147	arg1	the					2122:2124	the	2122:2124	the	2122:2124	The findings show a better overall carbon footprint for the biocomposite compared to the BPA-based composite at almost all times, demonstrating a good potential for marketability especially in the presence of incentives or regulations that address reducing the carbon intensity of products.
32560446	2	51	theme	life	624:627	arg1	LCA					647:649	LCA	647:649	LCA	647:649	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	2	51	theme	life	624:627	arg1	assessment					635:644	life cycle assessment	624:644	life cycle assessment (LCA) methodology	624:662	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	3	52	theme	resin	766:770	arg1	production					738:747	the production	734:747	the production of the bio-based resin used in the biocomposite	734:795	We evaluate the main environmental impacts that are generated during the production of the bio-based resin used in the biocomposite, as well as the biocomposite itself.
32560446	9	53	theme	better	1949:1954	arg1	footprint					1971:1979	a better overall carbon footprint	1947:1979	a better overall carbon footprint for the biocomposite compared to the BPA-based composite	1947:2036	The findings show a better overall carbon footprint for the biocomposite compared to the BPA-based composite at almost all times, demonstrating a good potential for marketability especially in the presence of incentives or regulations that address reducing the carbon intensity of products.
32560446	1	54	theme	economic	381:388	arg1	benefits					390:397	additional economic benefits	370:397	additional economic benefits	370:397	Biocomposites can be both environmentally and economically beneficial: during their life cycle they generally use and generate less petroleum-based carbon, and when produced from the byproduct of another industry or recycled back to the manufacturing process, they will bring additional economic benefits through contributing to a circular economy.
32560446	4	55	theme	petroleum-based	923:937	arg1	resin					939:943	a functionally similar petroleum-based resin	900:943	a functionally similar petroleum-based resin	900:943	We compare the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite, to identify tradeoffs between the environmental performance of the two products.
32560446	9	56	theme	carbon	1964:1969	arg1	footprint					1971:1979	a better overall carbon footprint	1947:1979	a better overall carbon footprint for the biocomposite compared to the BPA-based composite	1947:2036	The findings show a better overall carbon footprint for the biocomposite compared to the BPA-based composite at almost all times, demonstrating a good potential for marketability especially in the presence of incentives or regulations that address reducing the carbon intensity of products.
32560446	9	57	theme	carbon	2190:2195	arg1	intensity					2197:2205	the carbon intensity	2186:2205	the carbon intensity of products	2186:2217	The findings show a better overall carbon footprint for the biocomposite compared to the BPA-based composite at almost all times, demonstrating a good potential for marketability especially in the presence of incentives or regulations that address reducing the carbon intensity of products.
32560446	8	58	theme	uncertainty	1763:1773	arg1	analysis					1775:1782	An uncertainty analysis	1760:1782	An uncertainty analysis	1760:1782	An uncertainty analysis was also performed to evaluate the effect of variation in LCA model inputs on the environmental results for both the biocomposite and composite.
32560446	4	59	theme	proposed	875:882	arg1	biocomposite					884:895	the proposed biocomposite	871:895	the proposed biocomposite	871:895	We compare the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite, to identify tradeoffs between the environmental performance of the two products.
32560446	8	60	from	variation	1829:1837	arg1	inputs					1852:1857	LCA model inputs	1842:1857	LCA model inputs	1842:1857	An uncertainty analysis was also performed to evaluate the effect of variation in LCA model inputs on the environmental results for both the biocomposite and composite.
32560446	2	61	theme	epoxidized	562:571	arg1	resin					555:559	a soybean oil-based resin	535:559	a soybean oil-based resin (epoxidized sucrose soyate)	535:587	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	2	61	theme	epoxidized	562:571	arg1	soyate					581:586	epoxidized sucrose soyate	562:586	epoxidized sucrose soyate	562:586	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	8	62	from	effect	1819:1824	arg1	results					1880:1886	the environmental results	1862:1886	the environmental results for both the biocomposite and composite	1862:1926	An uncertainty analysis was also performed to evaluate the effect of variation in LCA model inputs on the environmental results for both the biocomposite and composite.
32560446	8	62	from	effect	1819:1824	arg1	inputs					1852:1857	LCA model inputs	1842:1857	LCA model inputs	1842:1857	An uncertainty analysis was also performed to evaluate the effect of variation in LCA model inputs on the environmental results for both the biocomposite and composite.
32560446	1	63	theme	circular	425:432	arg1	economy					434:440	a circular economy	423:440	a circular economy	423:440	Biocomposites can be both environmentally and economically beneficial: during their life cycle they generally use and generate less petroleum-based carbon, and when produced from the byproduct of another industry or recycled back to the manufacturing process, they will bring additional economic benefits through contributing to a circular economy.
32560446	7	64	theme	biocomposite	1746:1757	arg1	performance					1727:1737	the overall environmental performance	1701:1737	the overall environmental performance of the biocomposite	1701:1757	For future designs, considering an alternative cross-linker to facilitate the bond between the bio-based resin and the flax fiber, may help improve the overall environmental performance of the biocomposite.
32560446	8	65	dep	biocomposite	1901:1912	arg1	the					1897:1899	the	1897:1899	the	1897:1899	An uncertainty analysis was also performed to evaluate the effect of variation in LCA model inputs on the environmental results for both the biocomposite and composite.
32560446	8	66	from	inputs	1852:1857	arg1	effect					1819:1824	the effect	1815:1824	the effect of variation in LCA model inputs on the environmental results for both the biocomposite and composite	1815:1926	An uncertainty analysis was also performed to evaluate the effect of variation in LCA model inputs on the environmental results for both the biocomposite and composite.
32560446	6	67	theme	bisphenol	1390:1398	arg1	BPA					1403:1405	BPA	1403:1405	BPA	1403:1405	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	6	67	theme	bisphenol	1390:1398	arg1	A					1400:1400	a bisphenol A	1388:1400	a bisphenol A (BPA)	1388:1406	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	2	68	theme	environmental	479:491	arg1	performance					493:503	the environmental performance	475:503	the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology	475:662	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	9	69	theme	BPA-based	2018:2026	arg1	composite					2028:2036	the BPA-based composite	2014:2036	the BPA-based composite	2014:2036	The findings show a better overall carbon footprint for the biocomposite compared to the BPA-based composite at almost all times, demonstrating a good potential for marketability especially in the presence of incentives or regulations that address reducing the carbon intensity of products.
32560446	7	70	theme	environmental	1713:1725	arg1	performance					1727:1737	the overall environmental performance	1701:1737	the overall environmental performance of the biocomposite	1701:1757	For future designs, considering an alternative cross-linker to facilitate the bond between the bio-based resin and the flax fiber, may help improve the overall environmental performance of the biocomposite.
32560446	7	71	theme	future	1557:1562	arg1	designs					1564:1570	future designs	1557:1570	future designs	1557:1570	For future designs, considering an alternative cross-linker to facilitate the bond between the bio-based resin and the flax fiber, may help improve the overall environmental performance of the biocomposite.
32560446	6	72	theme	sucrose	1366:1372	arg1	soyate					1374:1379	epoxidized sucrose soyate	1355:1379	epoxidized sucrose soyate	1355:1379	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	5	73	theme	epoxidized	1104:1113	arg1	soyate					1123:1128	epoxidized sucrose soyate	1104:1128	epoxidized sucrose soyate	1104:1128	We demonstrate that the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin shows lower negative environmental impacts in most studied categories.
32560446	5	73	theme	epoxidized	1104:1113	arg1	resin					1097:1101	the bio-based resin	1083:1101	the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin	1083:1182	We demonstrate that the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin shows lower negative environmental impacts in most studied categories.
32560446	8	74	theme	variation	1829:1837	arg1	effect					1819:1824	the effect	1815:1824	the effect of variation in LCA model inputs on the environmental results for both the biocomposite and composite	1815:1926	An uncertainty analysis was also performed to evaluate the effect of variation in LCA model inputs on the environmental results for both the biocomposite and composite.
32560446	2	75	theme	biocomposite	510:521	arg1	performance					493:503	the environmental performance	475:503	the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology	475:662	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	1	76	theme	petroleum-based	226:240	arg1	carbon					242:247	less petroleum-based carbon	221:247	less petroleum-based carbon	221:247	Biocomposites can be both environmentally and economically beneficial: during their life cycle they generally use and generate less petroleum-based carbon, and when produced from the byproduct of another industry or recycled back to the manufacturing process, they will bring additional economic benefits through contributing to a circular economy.
32560446	0	77	theme	Preliminary	2:12	arg1	Assessment					28:37	A Preliminary Environmental Assessment	0:37	A Preliminary Environmental Assessment of Epoxidized Sucrose Soyate (ESS)	0:72	A Preliminary Environmental Assessment of Epoxidized Sucrose Soyate (ESS)-Based Biocomposite.
32560446	0	77	theme	Preliminary	2:12	arg1	ESS					69:71	ESS	69:71	ESS	69:71	A Preliminary Environmental Assessment of Epoxidized Sucrose Soyate (ESS)-Based Biocomposite.
32560446	8	78	theme	LCA	1842:1844	arg1	inputs					1852:1857	LCA model inputs	1842:1857	LCA model inputs	1842:1857	An uncertainty analysis was also performed to evaluate the effect of variation in LCA model inputs on the environmental results for both the biocomposite and composite.
32560446	6	79	theme	epoxy	1414:1418	arg1	resin					1420:1424	epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin	1355:1424	epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin	1355:1424	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	7	80	theme	flax	1672:1675	arg1	fiber					1677:1681	the flax fiber	1668:1681	the flax fiber	1668:1681	For future designs, considering an alternative cross-linker to facilitate the bond between the bio-based resin and the flax fiber, may help improve the overall environmental performance of the biocomposite.
32560446	4	81	theme	fiber	954:958	arg1	composite					971:979	flax fiber reinforced composite	949:979	flax fiber reinforced composite	949:979	We compare the life cycle impacts of the proposed biocomposite to a functionally similar petroleum-based resin and flax fiber reinforced composite, to identify tradeoffs between the environmental performance of the two products.
32560446	0	82	theme	Soyate	61:66	arg1	Assessment					28:37	A Preliminary Environmental Assessment	0:37	A Preliminary Environmental Assessment of Epoxidized Sucrose Soyate (ESS)	0:72	A Preliminary Environmental Assessment of Epoxidized Sucrose Soyate (ESS)-Based Biocomposite.
32560446	0	82	theme	Soyate	61:66	arg1	ESS					69:71	ESS	69:71	ESS	69:71	A Preliminary Environmental Assessment of Epoxidized Sucrose Soyate (ESS)-Based Biocomposite.
32560446	2	83	theme	soybean	537:543	arg1	resin					555:559	a soybean oil-based resin	535:559	a soybean oil-based resin (epoxidized sucrose soyate)	535:587	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	2	83	theme	soybean	537:543	arg1	soyate					581:586	epoxidized sucrose soyate	562:586	epoxidized sucrose soyate	562:586	Here we investigate and compare the environmental performance of a biocomposite composed of a soybean oil-based resin (epoxidized sucrose soyate) and flax-based reinforcement using life cycle assessment (LCA) methodology.
32560446	10	84	theme	future	2315:2320	arg1	modifications					2322:2334	future modifications	2315:2334	future modifications to improve the product's sustainability	2315:2374	This analysis allowed us to pinpoint hotspots in the biocomposite's supply chain and recommend future modifications to improve the product's sustainability.
32560446	5	85	theme	A-based	1169:1175	arg1	resin					1178:1182	a conventional (bisphenol A-based) resin	1143:1182	a conventional (bisphenol A-based) resin	1143:1182	We demonstrate that the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin shows lower negative environmental impacts in most studied categories.
32560446	6	86	from	performance	1456:1466	arg1	categories					1493:1502	most categories	1488:1502	most categories except eutrophication and ozone layer depletion	1488:1550	When comparing the biocomposite to the fossil fuel derived composite, it is demonstrated that using epoxidized sucrose soyate versus a bisphenol A (BPA)-based epoxy resin can improve the environmental performance of the composite in most categories except eutrophication and ozone layer depletion.
32560446	5	87	theme	studied	1235:1241	arg1	categories					1243:1252	most studied categories	1230:1252	most studied categories	1230:1252	We demonstrate that the bio-based resin (epoxidized sucrose soyate) compared to a conventional (bisphenol A-based) resin shows lower negative environmental impacts in most studied categories.
34551196	2	0	theme	solvents	521:528	arg1	use					506:508	the minimal use	494:508	the minimal use of organic solvents	494:528	Compared with traditional pesticides, nanopesticide formulations can achieve better foliar wettability, chemical stability, and water dispersibility without or with the minimal use of organic solvents, in line with the development of sustainable agriculture.
34551196	5	1	theme	leaf	1084:1087	arg1	surface					1089:1095	the leaf surface	1080:1095	the leaf surface	1080:1095	The good affinity of the composite towards leaves led to the effective moistening of the leaf surface by the pesticide and through the pH control pesticide release.
34551196	4	2	theme	EB	865:866	arg1	CMC-PGMA-GLY					851:862	A nanopesticide EB@CMC-PGMA-GLY	832:862	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG)	832:871	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	4	2	theme	EB	865:866	arg1	CPG					868:870	EB@CPG	865:870	EB@CPG	865:870	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	3	3	used	used	646:649	arg2	intermediate					657:668	an intermediate	654:668	an intermediate	654:668	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	3	used	used	646:649	arg2	GMA					637:639	GMA	637:639	GMA	637:639	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	3	used	used	646:649	arg2	methacrylate					623:634	glycidyl methacrylate	614:634	glycidyl methacrylate (GMA)	614:640	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	8	4	theme	agriculture	1634:1644	arg1	development					1607:1617	the development	1603:1617	the development of sustainable agriculture	1603:1644	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34551196	8	5	theme	new	1588:1590	arg1	method					1592:1597	a new method	1586:1597	a new method for the development of sustainable agriculture	1586:1644	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34551196	0	6	theme	based	99:103	arg1	carriers					105:112	amino acid-modified cellulose based carriers	69:112	amino acid-modified cellulose based carriers	69:112	A high-efficient nano pesticide-fertilizer combination fabricated by amino acid-modified cellulose based carriers.
34551196	5	7	theme	surface	1089:1095	arg1	moistening					1066:1075	the effective moistening	1052:1075	the effective moistening of the leaf surface by the pesticide and through the pH control pesticide release	1052:1157	The good affinity of the composite towards leaves led to the effective moistening of the leaf surface by the pesticide and through the pH control pesticide release.
34551196	1	8	dep	BACKGROUND	115:124	arg1	population					140:149	the global population grows	129:155	the global population grows	129:155	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	8	9	theme	environmentally	1464:1478	arg1	carrier					1499:1505	This environmentally friendly pesticide carrier	1459:1505	This environmentally friendly pesticide carrier	1459:1505	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34551196	8	9	theme	environmentally	1464:1478	arg1	fertilizer					1524:1533	a fertilizer	1522:1533	a fertilizer	1522:1533	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34551196	5	10	theme	pH	1130:1131	arg1	release					1151:1157	the pH control pesticide release	1126:1157	the pH control pesticide release	1126:1157	The good affinity of the composite towards leaves led to the effective moistening of the leaf surface by the pesticide and through the pH control pesticide release.
34551196	1	11	theme	efficient	262:270	arg1	pesticides					301:310	efficient and environmentally friendly pesticides	262:310	efficient and environmentally friendly pesticides	262:310	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	3	12	theme	organic	716:722	arg1	source					733:738	an organic nitrogen source	713:738	an organic nitrogen source	713:738	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	12	theme	organic	716:722	arg1	ester					689:693	glycine methyl ester	674:693	glycine methyl ester (GLY)	674:699	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	4	13	theme	@	867:867	arg1	CMC-PGMA-GLY					851:862	A nanopesticide EB@CMC-PGMA-GLY	832:862	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG)	832:871	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	4	13	theme	@	867:867	arg1	CPG					868:870	EB@CPG	865:870	EB@CPG	865:870	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	9	14	theme	Chemical	1665:1672	arg1	Industry					1674:1681	Chemical Industry	1665:1681	Chemical Industry	1665:1681	© 2021 Society of Chemical Industry.
34551196	8	15	dep	CONCLUSIONS	1447:1457	arg1	used					1514:1517	used	1514:1517	can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture	1507:1644	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34551196	4	16	theme	benzoate	947:954	arg1	interactions					921:932	the hydrophobic and electrostatic interactions	887:932	the hydrophobic and electrostatic interactions	887:932	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	2	17	theme	nanopesticide	367:379	arg1	formulations					381:392	nanopesticide formulations	367:392	nanopesticide formulations	367:392	Compared with traditional pesticides, nanopesticide formulations can achieve better foliar wettability, chemical stability, and water dispersibility without or with the minimal use of organic solvents, in line with the development of sustainable agriculture.
34551196	4	18	theme	EB	848:849	arg1	CMC-PGMA-GLY					851:862	A nanopesticide EB@CMC-PGMA-GLY	832:862	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG)	832:871	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	4	18	theme	EB	848:849	arg1	CPG					868:870	EB@CPG	865:870	EB@CPG	865:870	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	4	19	contain	had	968:970	arg1	interactions					921:932	the hydrophobic and electrostatic interactions	887:932	the hydrophobic and electrostatic interactions	887:932	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	4	19	contain	had	968:970	arg2	dispersion					983:992	good water dispersion	972:992	good water dispersion	972:992	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	6	20	contain	have	1252:1255	arg2	toxicity					1260:1267	no toxicity	1257:1267	no toxicity	1257:1267	Biological experiments show that nanopesticides can maintain high insecticidal activity and have no toxicity to seed germination.
34551196	6	20	contain	have	1252:1255	arg1	nanopesticides					1193:1206	nanopesticides	1193:1206	nanopesticides	1193:1206	Biological experiments show that nanopesticides can maintain high insecticidal activity and have no toxicity to seed germination.
34551196	2	21	theme	chemical	433:440	arg1	stability					442:450	chemical stability	433:450	chemical stability	433:450	Compared with traditional pesticides, nanopesticide formulations can achieve better foliar wettability, chemical stability, and water dispersibility without or with the minimal use of organic solvents, in line with the development of sustainable agriculture.
34551196	4	22	theme	emamectin	937:945	arg1	EB					957:958	EB	957:958	EB	957:958	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	4	22	theme	emamectin	937:945	arg1	benzoate					947:954	emamectin benzoate	937:954	emamectin benzoate (EB)	937:959	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	7	23	theme	fresh	1413:1417	arg1	weight					1419:1424	the fresh weight	1409:1424	the fresh weight of plants	1409:1434	The results of pot experiment showed that the nanocarriers could be used as an organic nitrogen fertilizer to increase the fresh weight of plants by 39.77%.
34551196	4	24	theme	nanopesticide	834:846	arg1	CMC-PGMA-GLY					851:862	A nanopesticide EB@CMC-PGMA-GLY	832:862	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG)	832:871	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	4	24	theme	nanopesticide	834:846	arg1	CPG					868:870	EB@CPG	865:870	EB@CPG	865:870	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	1	25	dep	population	140:149	arg1	grows					151:155	grows	151:155	grows	151:155	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	5	26	theme	effective	1056:1064	arg1	moistening					1066:1075	the effective moistening	1052:1075	the effective moistening of the leaf surface by the pesticide and through the pH control pesticide release	1052:1157	The good affinity of the composite towards leaves led to the effective moistening of the leaf surface by the pesticide and through the pH control pesticide release.
34551196	7	27	theme	pot	1305:1307	arg1	experiment					1309:1318	pot experiment	1305:1318	pot experiment	1305:1318	The results of pot experiment showed that the nanocarriers could be used as an organic nitrogen fertilizer to increase the fresh weight of plants by 39.77%.
34551196	0	28	theme	high-efficient	2:15	arg1	combination					43:53	A high-efficient nano pesticide-fertilizer combination	0:53	A high-efficient nano pesticide-fertilizer combination	0:53	A high-efficient nano pesticide-fertilizer combination fabricated by amino acid-modified cellulose based carriers.
34551196	2	29	theme	organic	513:519	arg1	solvents					521:528	organic solvents	513:528	organic solvents	513:528	Compared with traditional pesticides, nanopesticide formulations can achieve better foliar wettability, chemical stability, and water dispersibility without or with the minimal use of organic solvents, in line with the development of sustainable agriculture.
34551196	6	30	theme	high	1221:1224	arg1	activity					1239:1246	high insecticidal activity	1221:1246	high insecticidal activity	1221:1246	Biological experiments show that nanopesticides can maintain high insecticidal activity and have no toxicity to seed germination.
34551196	2	31	with	line	534:537	arg1	development					548:558	the development	544:558	the development of sustainable agriculture	544:585	Compared with traditional pesticides, nanopesticide formulations can achieve better foliar wettability, chemical stability, and water dispersibility without or with the minimal use of organic solvents, in line with the development of sustainable agriculture.
34551196	7	32	theme	organic	1369:1375	arg1	nanocarriers					1336:1347	the nanocarriers	1332:1347	the nanocarriers	1332:1347	The results of pot experiment showed that the nanocarriers could be used as an organic nitrogen fertilizer to increase the fresh weight of plants by 39.77%.
34551196	7	32	theme	organic	1369:1375	arg1	fertilizer					1386:1395	an organic nitrogen fertilizer	1366:1395	an organic nitrogen fertilizer	1366:1395	The results of pot experiment showed that the nanocarriers could be used as an organic nitrogen fertilizer to increase the fresh weight of plants by 39.77%.
34551196	3	33	theme	nitrogen	724:731	arg1	source					733:738	an organic nitrogen source	713:738	an organic nitrogen source	713:738	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	33	theme	nitrogen	724:731	arg1	ester					689:693	glycine methyl ester	674:693	glycine methyl ester (GLY)	674:699	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	4	34	theme	electrostatic	907:919	arg1	interactions					921:932	the hydrophobic and electrostatic interactions	887:932	the hydrophobic and electrostatic interactions	887:932	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	1	35	theme	environmentally	276:290	arg1	pesticides					301:310	efficient and environmentally friendly pesticides	262:310	efficient and environmentally friendly pesticides	262:310	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	4	36	theme	@	850:850	arg1	CMC-PGMA-GLY					851:862	A nanopesticide EB@CMC-PGMA-GLY	832:862	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG)	832:871	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	4	36	theme	@	850:850	arg1	CPG					868:870	EB@CPG	865:870	EB@CPG	865:870	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	4	37	theme	water	977:981	arg1	dispersion					983:992	good water dispersion	972:992	good water dispersion	972:992	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	7	38	theme	nitrogen	1377:1384	arg1	nanocarriers					1336:1347	the nanocarriers	1332:1347	the nanocarriers	1332:1347	The results of pot experiment showed that the nanocarriers could be used as an organic nitrogen fertilizer to increase the fresh weight of plants by 39.77%.
34551196	7	38	theme	nitrogen	1377:1384	arg1	fertilizer					1386:1395	an organic nitrogen fertilizer	1366:1395	an organic nitrogen fertilizer	1366:1395	The results of pot experiment showed that the nanocarriers could be used as an organic nitrogen fertilizer to increase the fresh weight of plants by 39.77%.
34551196	2	39	theme	foliar	413:418	arg1	wettability					420:430	foliar wettability	413:430	foliar wettability	413:430	Compared with traditional pesticides, nanopesticide formulations can achieve better foliar wettability, chemical stability, and water dispersibility without or with the minimal use of organic solvents, in line with the development of sustainable agriculture.
34551196	0	40	theme	pesticide-fertilizer	22:41	arg1	combination					43:53	A high-efficient nano pesticide-fertilizer combination	0:53	A high-efficient nano pesticide-fertilizer combination	0:53	A high-efficient nano pesticide-fertilizer combination fabricated by amino acid-modified cellulose based carriers.
34551196	1	41	theme	friendly	292:299	arg1	pesticides					301:310	efficient and environmentally friendly pesticides	262:310	efficient and environmentally friendly pesticides	262:310	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	4	42	theme	hydrophobic	891:901	arg1	interactions					921:932	the hydrophobic and electrostatic interactions	887:932	the hydrophobic and electrostatic interactions	887:932	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	5	43	theme	good	999:1002	arg1	affinity					1004:1011	The good affinity	995:1011	The good affinity of the composite towards leaves	995:1043	The good affinity of the composite towards leaves led to the effective moistening of the leaf surface by the pesticide and through the pH control pesticide release.
34551196	3	44	theme	nanocarrier	806:816	arg1	CMC-PGMA-GLY					818:829	a pesticide nanocarrier CMC-PGMA-GLY	794:829	a pesticide nanocarrier CMC-PGMA-GLY	794:829	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	2	45	theme	water	457:461	arg1	dispersibility					463:476	water dispersibility	457:476	water dispersibility	457:476	Compared with traditional pesticides, nanopesticide formulations can achieve better foliar wettability, chemical stability, and water dispersibility without or with the minimal use of organic solvents, in line with the development of sustainable agriculture.
34551196	0	46	theme	nano	17:20	arg1	combination					43:53	A high-efficient nano pesticide-fertilizer combination	0:53	A high-efficient nano pesticide-fertilizer combination	0:53	A high-efficient nano pesticide-fertilizer combination fabricated by amino acid-modified cellulose based carriers.
34551196	5	47	theme	control	1133:1139	arg1	release					1151:1157	the pH control pesticide release	1126:1157	the pH control pesticide release	1126:1157	The good affinity of the composite towards leaves led to the effective moistening of the leaf surface by the pesticide and through the pH control pesticide release.
34551196	2	48	theme	agriculture	575:585	arg1	development					548:558	the development	544:558	the development of sustainable agriculture	544:585	Compared with traditional pesticides, nanopesticide formulations can achieve better foliar wettability, chemical stability, and water dispersibility without or with the minimal use of organic solvents, in line with the development of sustainable agriculture.
34551196	1	49	theme	agrochemicals	178:190	arg1	quantities					164:173	large quantities	158:173	large quantities of agrochemicals	158:190	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	1	49	theme	agrochemicals	178:190	arg1	BACKGROUND					115:124	BACKGROUND	115:124	BACKGROUND	115:124	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	2	50	theme	minimal	498:504	arg1	use					506:508	the minimal use	494:508	the minimal use of organic solvents	494:528	Compared with traditional pesticides, nanopesticide formulations can achieve better foliar wettability, chemical stability, and water dispersibility without or with the minimal use of organic solvents, in line with the development of sustainable agriculture.
34551196	3	51	dep	RESULTS	588:594	arg1	used					705:708	used	705:708	was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY	701:829	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	51	dep	RESULTS	588:594	arg1	used					646:649	used	646:649	was used as an intermediate	642:668	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	5	52	theme	pesticide	1141:1149	arg1	release					1151:1157	the pH control pesticide release	1126:1157	the pH control pesticide release	1126:1157	The good affinity of the composite towards leaves led to the effective moistening of the leaf surface by the pesticide and through the pH control pesticide release.
34551196	2	53	theme	sustainable	563:573	arg1	agriculture					575:585	sustainable agriculture	563:585	sustainable agriculture	563:585	Compared with traditional pesticides, nanopesticide formulations can achieve better foliar wettability, chemical stability, and water dispersibility without or with the minimal use of organic solvents, in line with the development of sustainable agriculture.
34551196	6	54	theme	insecticidal	1226:1237	arg1	activity					1239:1246	high insecticidal activity	1221:1246	high insecticidal activity	1221:1246	Biological experiments show that nanopesticides can maintain high insecticidal activity and have no toxicity to seed germination.
34551196	7	55	theme	plants	1429:1434	arg1	weight					1419:1424	the fresh weight	1409:1424	the fresh weight of plants	1409:1434	The results of pot experiment showed that the nanocarriers could be used as an organic nitrogen fertilizer to increase the fresh weight of plants by 39.77%.
34551196	3	56	used	used	705:708	arg2	GLY					696:698	GLY	696:698	GLY	696:698	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	56	used	used	705:708	arg2	ester					689:693	glycine methyl ester	674:693	glycine methyl ester (GLY)	674:699	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	56	used	used	705:708	arg2	source					733:738	an organic nitrogen source	713:738	an organic nitrogen source	713:738	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	8	57	theme	sufficient	1546:1555	arg1	nutrients					1557:1565	sufficient nutrients	1546:1565	sufficient nutrients	1546:1565	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34551196	0	58	theme	amino	69:73	arg1	carriers					105:112	amino acid-modified cellulose based carriers	69:112	amino acid-modified cellulose based carriers	69:112	A high-efficient nano pesticide-fertilizer combination fabricated by amino acid-modified cellulose based carriers.
34551196	7	59	theme	experiment	1309:1318	arg1	results					1294:1300	The results	1290:1300	The results of pot experiment	1290:1318	The results of pot experiment showed that the nanocarriers could be used as an organic nitrogen fertilizer to increase the fresh weight of plants by 39.77%.
34551196	3	60	theme	carboxymethyl	750:762	arg1	CMC					775:777	CMC	775:777	CMC	775:777	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	60	theme	carboxymethyl	750:762	arg1	cellulose					764:772	carboxymethyl cellulose	750:772	carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY	750:829	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	8	61	dep	crops	1571:1575	arg1	opening					1578:1584	opening	1578:1584	opening	1578:1584	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34551196	1	62	theme	global	133:138	arg1	population					140:149	the global population grows	129:155	the global population grows	129:155	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	4	63	theme	good	972:975	arg1	dispersion					983:992	good water dispersion	972:992	good water dispersion	972:992	A nanopesticide EB@CMC-PGMA-GLY (EB@CPG) was formed by the hydrophobic and electrostatic interactions of emamectin benzoate (EB), which had good water dispersion.
34551196	3	64	theme	glycidyl	614:621	arg1	methacrylate					623:634	glycidyl methacrylate	614:634	glycidyl methacrylate (GMA)	614:640	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	64	theme	glycidyl	614:621	arg1	intermediate					657:668	an intermediate	654:668	an intermediate	654:668	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	64	theme	glycidyl	614:621	arg1	GMA					637:639	GMA	637:639	GMA	637:639	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	8	65	used	used	1514:1517	arg2	carrier					1499:1505	This environmentally friendly pesticide carrier	1459:1505	This environmentally friendly pesticide carrier	1459:1505	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34551196	8	65	used	used	1514:1517	arg2	fertilizer					1524:1533	a fertilizer	1522:1533	a fertilizer	1522:1533	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34551196	5	66	theme	composite	1020:1028	arg1	affinity					1004:1011	The good affinity	995:1011	The good affinity of the composite towards leaves	995:1043	The good affinity of the composite towards leaves led to the effective moistening of the leaf surface by the pesticide and through the pH control pesticide release.
34551196	6	67	theme	seed	1272:1275	arg1	germination					1277:1287	seed germination	1272:1287	seed germination	1272:1287	Biological experiments show that nanopesticides can maintain high insecticidal activity and have no toxicity to seed germination.
34551196	7	68	used	used	1358:1361	arg2	nanocarriers					1336:1347	the nanocarriers	1332:1347	the nanocarriers	1332:1347	The results of pot experiment showed that the nanocarriers could be used as an organic nitrogen fertilizer to increase the fresh weight of plants by 39.77%.
34551196	7	68	used	used	1358:1361	arg2	fertilizer					1386:1395	an organic nitrogen fertilizer	1366:1395	an organic nitrogen fertilizer	1366:1395	The results of pot experiment showed that the nanocarriers could be used as an organic nitrogen fertilizer to increase the fresh weight of plants by 39.77%.
34551196	8	69	theme	pesticide	1489:1497	arg1	carrier					1499:1505	This environmentally friendly pesticide carrier	1459:1505	This environmentally friendly pesticide carrier	1459:1505	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34551196	8	69	theme	pesticide	1489:1497	arg1	fertilizer					1524:1533	a fertilizer	1522:1533	a fertilizer	1522:1533	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34551196	3	70	theme	glycine	674:680	arg1	GLY					696:698	GLY	696:698	GLY	696:698	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	70	theme	glycine	674:680	arg1	ester					689:693	glycine methyl ester	674:693	glycine methyl ester (GLY)	674:699	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	70	theme	glycine	674:680	arg1	source					733:738	an organic nitrogen source	713:738	an organic nitrogen source	713:738	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	6	71	theme	Biological	1160:1169	arg1	experiments					1171:1181	Biological experiments	1160:1181	Biological experiments	1160:1181	Biological experiments show that nanopesticides can maintain high insecticidal activity and have no toxicity to seed germination.
34551196	2	72	theme	traditional	343:353	arg1	pesticides					355:364	traditional pesticides	343:364	traditional pesticides	343:364	Compared with traditional pesticides, nanopesticide formulations can achieve better foliar wettability, chemical stability, and water dispersibility without or with the minimal use of organic solvents, in line with the development of sustainable agriculture.
34551196	8	73	theme	sustainable	1622:1632	arg1	agriculture					1634:1644	sustainable agriculture	1622:1644	sustainable agriculture	1622:1644	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34551196	3	74	theme	pesticide	796:804	arg1	CMC-PGMA-GLY					818:829	a pesticide nanocarrier CMC-PGMA-GLY	794:829	a pesticide nanocarrier CMC-PGMA-GLY	794:829	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	0	75	theme	cellulose	89:97	arg1	carriers					105:112	amino acid-modified cellulose based carriers	69:112	amino acid-modified cellulose based carriers	69:112	A high-efficient nano pesticide-fertilizer combination fabricated by amino acid-modified cellulose based carriers.
34551196	3	76	theme	methyl	682:687	arg1	GLY					696:698	GLY	696:698	GLY	696:698	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	76	theme	methyl	682:687	arg1	ester					689:693	glycine methyl ester	674:693	glycine methyl ester (GLY)	674:699	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	3	76	theme	methyl	682:687	arg1	source					733:738	an organic nitrogen source	713:738	an organic nitrogen source	713:738	RESULTS In this research, glycidyl methacrylate (GMA) was used as an intermediate and glycine methyl ester (GLY) was used as an organic nitrogen source to modify carboxymethyl cellulose (CMC) to synthesize a pesticide nanocarrier CMC-PGMA-GLY.
34551196	1	77	used	used	196:199	arg2	quantities					164:173	large quantities	158:173	large quantities of agrochemicals	158:190	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	1	77	used	used	196:199	arg2	BACKGROUND					115:124	BACKGROUND	115:124	BACKGROUND	115:124	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	1	78	theme	food	211:214	arg1	demand					216:221	food demand	211:221	food demand	211:221	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	1	79	theme	large	158:162	arg1	quantities					164:173	large quantities	158:173	large quantities of agrochemicals	158:190	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	1	79	theme	large	158:162	arg1	BACKGROUND					115:124	BACKGROUND	115:124	BACKGROUND	115:124	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	1	80	theme	urgent	239:244	arg1	need					246:249	an urgent need	236:249	an urgent need to develop efficient and environmentally friendly pesticides and fertilizers	236:326	BACKGROUND As the global population grows, large quantities of agrochemicals are used to secure food demand and there is an urgent need to develop efficient and environmentally friendly pesticides and fertilizers.
34551196	0	81	theme	acid-modified	75:87	arg1	carriers					105:112	amino acid-modified cellulose based carriers	69:112	amino acid-modified cellulose based carriers	69:112	A high-efficient nano pesticide-fertilizer combination fabricated by amino acid-modified cellulose based carriers.
34551196	8	82	theme	friendly	1480:1487	arg1	carrier					1499:1505	This environmentally friendly pesticide carrier	1459:1505	This environmentally friendly pesticide carrier	1459:1505	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34551196	8	82	theme	friendly	1480:1487	arg1	fertilizer					1524:1533	a fertilizer	1522:1533	a fertilizer	1522:1533	CONCLUSIONS This environmentally friendly pesticide carrier can be used as a fertilizer to provide sufficient nutrients for crops, opening a new method for the development of sustainable agriculture.
34677430	3	0	dep	structure	685:693	arg1	the					668:670	the	668:670	the	668:670	However, its utilization for applying biopolymer layers on textiles is very limited due to the more complex structure and spatial characteristics of fibrous materials.
34677430	2	1	contain	has	340:342	arg1	deposition					323:332	Electrophoretic deposition	307:332	Electrophoretic deposition (EPD)	307:338	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	1	contain	has	340:342	arg2	versatility					378:388	its versatility	374:388	its versatility	374:388	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	1	contain	has	340:342	arg1	EPD					335:337	EPD	335:337	EPD	335:337	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	1	contain	has	340:342	arg2	advantages					352:361	several advantages	344:361	several advantages	344:361	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	1	contain	has	340:342	arg2	simplicity					391:400	simplicity	391:400	simplicity	391:400	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	1	contain	has	340:342	arg2	ability					407:413	ability	407:413	ability to coat substrates with complex shapes	407:452	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	2	from	coatings	516:523	arg1	biomaterials					537:548	metallic biomaterials	528:548	metallic biomaterials	528:548	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	8	3	theme	method	1580:1585	arg1	discussion					1537:1546	discussion	1537:1546	discussion	1537:1546	This study serves as a basis for discussion and further development of this method with regard to fibrous materials for medical applications.
34677430	8	3	theme	method	1580:1585	arg1	development					1560:1570	further development	1552:1570	further development	1552:1570	This study serves as a basis for discussion and further development of this method with regard to fibrous materials for medical applications.
34677430	6	4	theme	molecular	1280:1288	arg1	analysis					1300:1307	molecular structure analysis	1280:1307	molecular structure analysis	1280:1307	The morphology and structure of the created deposits were analyzed using scanning electron microscopy and computed tomography, and molecular structure analysis was performed with Fourier Transform Infrared spectroscopy.
34677430	6	5	dep	morphology	1153:1162	arg1	The					1149:1151	The	1149:1151	The	1149:1151	The morphology and structure of the created deposits were analyzed using scanning electron microscopy and computed tomography, and molecular structure analysis was performed with Fourier Transform Infrared spectroscopy.
34677430	0	6	theme	Structure	102:110	arg1	Effect					84:89	The Effect	80:89	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.	0:145	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.
34677430	2	7	used	used	462:465	arg2	EPD					335:337	EPD	335:337	EPD	335:337	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	7	used	used	462:465	arg2	deposition					323:332	Electrophoretic deposition	307:332	Electrophoretic deposition (EPD)	307:338	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	4	8	theme	carriers	878:885	arg1	parameters					821:830	selected EPD process parameters	800:830	selected EPD process parameters	800:830	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	4	8	theme	carriers	878:885	arg1	characteristics					851:865	the structural characteristics	836:865	the structural characteristics of fibrous carriers	836:885	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	4	9	theme	process	813:819	arg1	parameters					821:830	selected EPD process parameters	800:830	selected EPD process parameters	800:830	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	6	10	theme	created	1185:1191	arg1	deposits					1193:1200	the created deposits	1181:1200	the created deposits	1181:1200	The morphology and structure of the created deposits were analyzed using scanning electron microscopy and computed tomography, and molecular structure analysis was performed with Fourier Transform Infrared spectroscopy.
34677430	0	11	theme	Carrier	94:100	arg1	Structure					102:110	Carrier Structure	94:110	Carrier Structure	94:110	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.
34677430	4	12	theme	characteristics	851:865	arg1	effects					789:795	the effects	785:795	the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers	785:976	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	4	13	theme	fibrous	870:876	arg1	carriers					878:885	fibrous carriers	870:885	fibrous carriers	870:885	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	0	14	theme	Solution	113:120	arg1	Effect					84:89	The Effect	80:89	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.	0:145	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.
34677430	3	15	theme	fibrous	726:732	arg1	materials					734:742	fibrous materials	726:742	fibrous materials	726:742	However, its utilization for applying biopolymer layers on textiles is very limited due to the more complex structure and spatial characteristics of fibrous materials.
34677430	7	16	theme	carriers	1436:1443	arg1	thickness					1390:1398	thickness	1390:1398	thickness	1390:1398	The surface mass and thickness of fibrous poly (lactic acid)-based carriers were analyzed in accordance with the respective standards.
34677430	7	16	theme	carriers	1436:1443	arg1	mass					1381:1384	surface mass	1373:1384	surface mass	1373:1384	The surface mass and thickness of fibrous poly (lactic acid)-based carriers were analyzed in accordance with the respective standards.
34677430	7	17	theme	surface	1373:1379	arg1	mass					1381:1384	surface mass	1373:1384	surface mass	1373:1384	The surface mass and thickness of fibrous poly (lactic acid)-based carriers were analyzed in accordance with the respective standards.
34677430	8	18	theme	medical	1624:1630	arg1	applications					1632:1643	medical applications	1624:1643	medical applications	1624:1643	This study serves as a basis for discussion and further development of this method with regard to fibrous materials for medical applications.
34677430	2	19	theme	antimicrobial	487:499	arg1	coatings					516:523	antimicrobial or hydrophobic coatings	487:523	antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications	487:574	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	3	20	theme	spatial	699:705	arg1	characteristics					707:721	spatial characteristics	699:721	spatial characteristics	699:721	However, its utilization for applying biopolymer layers on textiles is very limited due to the more complex structure and spatial characteristics of fibrous materials.
34677430	4	21	theme	parameters	821:830	arg1	effects					789:795	the effects	785:795	the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers	785:976	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	0	22	theme	Polymer-Based	0:12	arg1	Deposition					30:39	Polymer-Based Electrophoretic Deposition	0:39	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.	0:145	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.
34677430	5	23	theme	characteristics	1005:1019	arg1	influence					983:991	The influence	979:991	The influence of solution characteristics, process parameters, and carrier structures obtained using two different techniques (melt blown and spun-bonded)	979:1132	The influence of solution characteristics, process parameters, and carrier structures obtained using two different techniques (melt blown and spun-bonded) were analyzed.
34677430	1	24	theme	non-toxic	176:184	arg1	Hyaluronate					147:157	Hyaluronate	147:157	Hyaluronate	147:157	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	1	24	theme	non-toxic	176:184	arg1	polymers					204:211	non-toxic and biocompatible polymers	176:211	non-toxic and biocompatible polymers	176:211	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	1	24	theme	non-toxic	176:184	arg1	alginate					163:170	alginate	163:170	alginate	163:170	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	0	25	theme	Electrophoretic	14:28	arg1	Deposition					30:39	Polymer-Based Electrophoretic Deposition	0:39	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.	0:145	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.
34677430	4	26	theme	structural	840:849	arg1	characteristics					851:865	the structural characteristics	836:865	the structural characteristics of fibrous carriers	836:885	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	7	27	theme	respective	1482:1491	arg1	standards					1493:1501	the respective standards	1478:1501	the respective standards	1478:1501	The surface mass and thickness of fibrous poly (lactic acid)-based carriers were analyzed in accordance with the respective standards.
34677430	3	28	theme	complex	677:683	arg1	structure					685:693	more complex structure	672:693	more complex structure	672:693	However, its utilization for applying biopolymer layers on textiles is very limited due to the more complex structure and spatial characteristics of fibrous materials.
34677430	2	29	theme	complex	439:445	arg1	shapes					447:452	complex shapes	439:452	complex shapes	439:452	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	1	30	theme	many	282:285	arg1	kinds					287:291	many kinds	282:291	many kinds of materials	282:304	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	6	31	theme	computed	1255:1262	arg1	tomography					1264:1273	computed tomography	1255:1273	computed tomography	1255:1273	The morphology and structure of the created deposits were analyzed using scanning electron microscopy and computed tomography, and molecular structure analysis was performed with Fourier Transform Infrared spectroscopy.
34677430	7	32	theme	-based	1429:1434	arg1	carriers					1436:1443	fibrous poly (lactic acid)-based carriers	1403:1443	fibrous poly (lactic acid)-based carriers	1403:1443	The surface mass and thickness of fibrous poly (lactic acid)-based carriers were analyzed in accordance with the respective standards.
34677430	1	33	theme	biocompatible	190:202	arg1	Hyaluronate					147:157	Hyaluronate	147:157	Hyaluronate	147:157	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	1	33	theme	biocompatible	190:202	arg1	polymers					204:211	non-toxic and biocompatible polymers	176:211	non-toxic and biocompatible polymers	176:211	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	1	33	theme	biocompatible	190:202	arg1	alginate					163:170	alginate	163:170	alginate	163:170	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	2	34	theme	metallic	528:535	arg1	biomaterials					537:548	metallic biomaterials	528:548	metallic biomaterials	528:548	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	1	35	theme	kinds	287:291	arg1	functionalization					261:277	functionalization	261:277	functionalization	261:277	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	1	35	theme	kinds	287:291	arg1	modification					244:255	surface modification	236:255	surface modification	236:255	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	4	36	theme	process	910:916	arg1	kinetics					894:901	the kinetics	890:901	the kinetics of the process	890:916	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	4	36	theme	process	910:916	arg1	characteristics					938:952	the microscopic characteristics	922:952	the microscopic characteristics of the deposited layers	922:976	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	6	37	theme	scanning	1222:1229	arg1	microscopy					1240:1249	scanning electron microscopy	1222:1249	scanning electron microscopy	1222:1249	The morphology and structure of the created deposits were analyzed using scanning electron microscopy and computed tomography, and molecular structure analysis was performed with Fourier Transform Infrared spectroscopy.
34677430	2	38	theme	Electrophoretic	307:321	arg1	EPD					335:337	EPD	335:337	EPD	335:337	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	38	theme	Electrophoretic	307:321	arg1	deposition					323:332	Electrophoretic deposition	307:332	Electrophoretic deposition (EPD)	307:338	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	7	39	theme	poly	1411:1414	arg1	carriers					1436:1443	fibrous poly (lactic acid)-based carriers	1403:1443	fibrous poly (lactic acid)-based carriers	1403:1443	The surface mass and thickness of fibrous poly (lactic acid)-based carriers were analyzed in accordance with the respective standards.
34677430	2	40	theme	coat	418:421	arg1	substrates					423:432	coat substrates	418:432	coat substrates with complex shapes	418:452	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	6	41	dep	Fourier	1328:1334	arg1	Transform					1336:1344	Transform	1336:1344	Transform Infrared spectroscopy	1336:1366	The morphology and structure of the created deposits were analyzed using scanning electron microscopy and computed tomography, and molecular structure analysis was performed with Fourier Transform Infrared spectroscopy.
34677430	3	42	theme	materials	734:742	arg1	structure					685:693	more complex structure	672:693	more complex structure	672:693	However, its utilization for applying biopolymer layers on textiles is very limited due to the more complex structure and spatial characteristics of fibrous materials.
34677430	3	42	theme	materials	734:742	arg1	characteristics					707:721	spatial characteristics	699:721	spatial characteristics	699:721	However, its utilization for applying biopolymer layers on textiles is very limited due to the more complex structure and spatial characteristics of fibrous materials.
34677430	5	43	theme	blown	1111:1115	arg1	melt					1106:1109	melt	1106:1109	melt blown and spun-bonded	1106:1131	The influence of solution characteristics, process parameters, and carrier structures obtained using two different techniques (melt blown and spun-bonded) were analyzed.
34677430	5	44	theme	parameters	1030:1039	arg1	influence					983:991	The influence	979:991	The influence of solution characteristics, process parameters, and carrier structures obtained using two different techniques (melt blown and spun-bonded)	979:1132	The influence of solution characteristics, process parameters, and carrier structures obtained using two different techniques (melt blown and spun-bonded) were analyzed.
34677430	7	45	dep	mass	1381:1384	arg1	The					1369:1371	The	1369:1371	The	1369:1371	The surface mass and thickness of fibrous poly (lactic acid)-based carriers were analyzed in accordance with the respective standards.
34677430	1	46	theme	materials	296:304	arg1	kinds					287:291	many kinds	282:291	many kinds of materials	282:304	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	0	47	theme	Parameters	135:144	arg1	Effect					84:89	The Effect	80:89	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.	0:145	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.
34677430	4	48	theme	selected	800:807	arg1	parameters					821:830	selected EPD process parameters	800:830	selected EPD process parameters	800:830	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	6	49	theme	deposits	1193:1200	arg1	morphology					1153:1162	morphology	1153:1162	morphology	1153:1162	The morphology and structure of the created deposits were analyzed using scanning electron microscopy and computed tomography, and molecular structure analysis was performed with Fourier Transform Infrared spectroscopy.
34677430	6	49	theme	deposits	1193:1200	arg1	structure					1168:1176	structure	1168:1176	structure	1168:1176	The morphology and structure of the created deposits were analyzed using scanning electron microscopy and computed tomography, and molecular structure analysis was performed with Fourier Transform Infrared spectroscopy.
34677430	0	50	theme	Nonwovens	44:52	arg1	Deposition					30:39	Polymer-Based Electrophoretic Deposition	0:39	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.	0:145	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.
34677430	0	51	theme	Process	127:133	arg1	Parameters					135:144	Process Parameters	127:144	Process Parameters	127:144	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.
34677430	5	52	theme	different	1084:1092	arg1	techniques					1094:1103	two different techniques	1080:1103	two different techniques (melt blown and spun-bonded)	1080:1132	The influence of solution characteristics, process parameters, and carrier structures obtained using two different techniques (melt blown and spun-bonded) were analyzed.
34677430	5	53	theme	process	1022:1028	arg1	parameters					1030:1039	process parameters	1022:1039	process parameters	1022:1039	The influence of solution characteristics, process parameters, and carrier structures obtained using two different techniques (melt blown and spun-bonded) were analyzed.
34677430	7	54	theme	fibrous	1403:1409	arg1	poly					1411:1414	fibrous poly	1403:1414	fibrous poly (lactic acid)-based carriers	1403:1443	The surface mass and thickness of fibrous poly (lactic acid)-based carriers were analyzed in accordance with the respective standards.
34677430	7	54	theme	fibrous	1403:1409	arg1	acid					1424:1427	lactic acid	1417:1427	lactic acid	1417:1427	The surface mass and thickness of fibrous poly (lactic acid)-based carriers were analyzed in accordance with the respective standards.
34677430	2	55	theme	coatings	516:523	arg1	creation					475:482	the creation	471:482	the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications	471:574	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	56	from	creation	475:482	arg1	biomaterials					537:548	metallic biomaterials	528:548	metallic biomaterials	528:548	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	57	theme	hydrophobic	504:514	arg1	coatings					516:523	antimicrobial or hydrophobic coatings	487:523	antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications	487:574	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	58	with	substrates	423:432	arg1	shapes					447:452	complex shapes	439:452	complex shapes	439:452	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	59	theme	several	344:350	arg1	simplicity					391:400	simplicity	391:400	simplicity	391:400	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	59	theme	several	344:350	arg1	ability					407:413	ability	407:413	ability to coat substrates with complex shapes	407:452	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	59	theme	several	344:350	arg1	versatility					378:388	its versatility	374:388	its versatility	374:388	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	2	59	theme	several	344:350	arg1	advantages					352:361	several advantages	344:361	several advantages	344:361	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	0	60	theme	Medical	58:64	arg1	Applications					66:77	Medical Applications	58:77	Medical Applications	58:77	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.
34677430	8	61	theme	fibrous	1602:1608	arg1	materials					1610:1618	fibrous materials	1602:1618	fibrous materials for medical applications	1602:1643	This study serves as a basis for discussion and further development of this method with regard to fibrous materials for medical applications.
34677430	5	62	dep	techniques	1094:1103	arg1	melt					1106:1109	melt	1106:1109	melt blown and spun-bonded	1106:1131	The influence of solution characteristics, process parameters, and carrier structures obtained using two different techniques (melt blown and spun-bonded) were analyzed.
34677430	4	63	theme	EPD	809:811	arg1	parameters					821:830	selected EPD process parameters	800:830	selected EPD process parameters	800:830	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	8	64	theme	further	1552:1558	arg1	development					1560:1570	further development	1552:1570	further development	1552:1570	This study serves as a basis for discussion and further development of this method with regard to fibrous materials for medical applications.
34677430	6	65	theme	structure	1290:1298	arg1	analysis					1300:1307	molecular structure analysis	1280:1307	molecular structure analysis	1280:1307	The morphology and structure of the created deposits were analyzed using scanning electron microscopy and computed tomography, and molecular structure analysis was performed with Fourier Transform Infrared spectroscopy.
34677430	1	66	mod	modification	244:255	arg1	kinds					287:291	many kinds	282:291	many kinds of materials	282:304	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	1	66	mod	modification	244:255	arg3	surface					236:242	surface modification	236:255	surface modification	236:255	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	2	67	theme	other	557:561	arg1	applications					563:574	other applications	557:574	other applications	557:574	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	5	68	theme	carrier	1046:1052	arg1	structures					1054:1063	carrier structures	1046:1063	carrier structures	1046:1063	The influence of solution characteristics, process parameters, and carrier structures obtained using two different techniques (melt blown and spun-bonded) were analyzed.
34677430	3	69	theme	biopolymer	615:624	arg1	layers					626:631	biopolymer layers	615:631	biopolymer layers	615:631	However, its utilization for applying biopolymer layers on textiles is very limited due to the more complex structure and spatial characteristics of fibrous materials.
34677430	7	70	theme	lactic	1417:1422	arg1	poly					1411:1414	fibrous poly	1403:1414	fibrous poly (lactic acid)-based carriers	1403:1443	The surface mass and thickness of fibrous poly (lactic acid)-based carriers were analyzed in accordance with the respective standards.
34677430	7	70	theme	lactic	1417:1422	arg1	acid					1424:1427	lactic acid	1417:1427	lactic acid	1417:1427	The surface mass and thickness of fibrous poly (lactic acid)-based carriers were analyzed in accordance with the respective standards.
34677430	6	71	theme	Infrared	1346:1353	arg1	spectroscopy					1355:1366	Infrared spectroscopy	1346:1366	Infrared spectroscopy	1346:1366	The morphology and structure of the created deposits were analyzed using scanning electron microscopy and computed tomography, and molecular structure analysis was performed with Fourier Transform Infrared spectroscopy.
34677430	4	72	theme	research	761:768	arg1	aim					749:751	The aim	745:751	The aim of this research	745:768	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	1	73	used	used	227:230	arg2	alginate					163:170	alginate	163:170	alginate	163:170	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	1	73	used	used	227:230	arg2	Hyaluronate					147:157	Hyaluronate	147:157	Hyaluronate	147:157	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	1	73	used	used	227:230	arg2	polymers					204:211	non-toxic and biocompatible polymers	176:211	non-toxic and biocompatible polymers	176:211	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
34677430	0	74	dep	Deposition	30:39	arg1	Effect					84:89	The Effect	80:89	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.	0:145	Polymer-Based Electrophoretic Deposition of Nonwovens for Medical Applications: The Effect of Carrier Structure, Solution, and Process Parameters.
34677430	4	75	from	effects	789:795	arg1	kinetics					894:901	the kinetics	890:901	the kinetics of the process	890:916	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	4	75	from	effects	789:795	arg1	characteristics					938:952	the microscopic characteristics	922:952	the microscopic characteristics of the deposited layers	922:976	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	4	76	theme	microscopic	926:936	arg1	characteristics					938:952	the microscopic characteristics	922:952	the microscopic characteristics of the deposited layers	922:976	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	5	77	theme	structures	1054:1063	arg1	influence					983:991	The influence	979:991	The influence of solution characteristics, process parameters, and carrier structures obtained using two different techniques (melt blown and spun-bonded)	979:1132	The influence of solution characteristics, process parameters, and carrier structures obtained using two different techniques (melt blown and spun-bonded) were analyzed.
34677430	4	78	theme	layers	971:976	arg1	kinetics					894:901	the kinetics	890:901	the kinetics of the process	890:916	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	4	78	theme	layers	971:976	arg1	characteristics					938:952	the microscopic characteristics	922:952	the microscopic characteristics of the deposited layers	922:976	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	5	79	theme	solution	996:1003	arg1	characteristics					1005:1019	solution characteristics	996:1019	solution characteristics	996:1019	The influence of solution characteristics, process parameters, and carrier structures obtained using two different techniques (melt blown and spun-bonded) were analyzed.
34677430	6	80	theme	electron	1231:1238	arg1	microscopy					1240:1249	scanning electron microscopy	1222:1249	scanning electron microscopy	1222:1249	The morphology and structure of the created deposits were analyzed using scanning electron microscopy and computed tomography, and molecular structure analysis was performed with Fourier Transform Infrared spectroscopy.
34677430	4	81	theme	deposited	961:969	arg1	layers					971:976	the deposited layers	957:976	the deposited layers	957:976	The aim of this research was to analyze the effects of selected EPD process parameters and the structural characteristics of fibrous carriers on the kinetics of the process and the microscopic characteristics of the deposited layers.
34677430	5	82	theme	spun-bonded	1121:1131	arg1	melt					1106:1109	melt	1106:1109	melt blown and spun-bonded	1106:1131	The influence of solution characteristics, process parameters, and carrier structures obtained using two different techniques (melt blown and spun-bonded) were analyzed.
34677430	2	83	from	biomaterials	537:548	arg1	creation					475:482	the creation	471:482	the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications	471:574	Electrophoretic deposition (EPD) has several advantages, including its versatility, simplicity, and ability to coat substrates with complex shapes, and is used for the creation of antimicrobial or hydrophobic coatings on metallic biomaterials, among other applications.
34677430	1	84	theme	surface	236:242	arg1	modification					244:255	surface modification	236:255	surface modification	236:255	Hyaluronate and alginate are non-toxic and biocompatible polymers, which can be used for surface modification and functionalization of many kinds of materials.
32348759	4	0	theme	PG	653:654	arg1	synthesis					656:664	PG synthesis	653:664	PG synthesis	653:664	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	4	1	theme	tetrapeptides	540:552	arg1	accumulation					515:526	the accumulation	511:526	the accumulation of recycled tetrapeptides	511:552	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	5	2	theme	different	727:735	arg1	species					737:743	five different species	722:743	five different species	722:743	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	5	3	from	species	737:743	arg1	l					695:695	l	695:695	l	695:695	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	5	3	from	species	737:743	arg1	d-carboxypeptidases					697:715	d-carboxypeptidases	697:715	d-carboxypeptidases from five different species	697:743	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	4	4	theme	recycled	531:538	arg1	tetrapeptides					540:552	recycled tetrapeptides	531:552	recycled tetrapeptides	531:552	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	5	5	theme	d-amino	858:864	arg1	acids					866:870	canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids	800:870	canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids	800:870	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	6	6	theme	stationary	1134:1143	arg1	phase					1145:1149	the stationary phase	1130:1149	the stationary phase	1130:1149	Collectively, this work reveals a regulatory role of NCDAA linking PG recycling and synthesis to promote optimal cell wall assembly and composition in the stationary phase.
32348759	6	7	theme	wall	1097:1100	arg1	assembly					1102:1109	optimal cell wall assembly	1084:1109	optimal cell wall assembly	1084:1109	Collectively, this work reveals a regulatory role of NCDAA linking PG recycling and synthesis to promote optimal cell wall assembly and composition in the stationary phase.
32348759	6	8	theme	NCDAA	1032:1036	arg1	role					1024:1027	a regulatory role	1011:1027	a regulatory role of NCDAA linking PG recycling and synthesis to promote optimal cell wall assembly and composition in the stationary phase	1011:1149	Collectively, this work reveals a regulatory role of NCDAA linking PG recycling and synthesis to promote optimal cell wall assembly and composition in the stationary phase.
32348759	3	9	theme	tetrapeptides	476:488	arg1	accumulation					447:458	the accumulation	443:458	the accumulation of cytosolic PG tetrapeptides	443:488	Here, we show that Vibrio cholerae recycles PG fragments modified with non-canonical d-amino acids (NCDAA), which lead to the accumulation of cytosolic PG tetrapeptides.
32348759	3	10	theme	d-amino	406:412	arg1	NCDAA					421:425	NCDAA	421:425	NCDAA	421:425	Here, we show that Vibrio cholerae recycles PG fragments modified with non-canonical d-amino acids (NCDAA), which lead to the accumulation of cytosolic PG tetrapeptides.
32348759	3	10	theme	d-amino	406:412	arg1	acids					414:418	non-canonical d-amino acids	392:418	non-canonical d-amino acids (NCDAA)	392:426	Here, we show that Vibrio cholerae recycles PG fragments modified with non-canonical d-amino acids (NCDAA), which lead to the accumulation of cytosolic PG tetrapeptides.
32348759	0	11	theme	Cell	50:53	arg1	Tetrapeptides					60:72	Recycled Cell Wall Tetrapeptides	41:72	Recycled Cell Wall Tetrapeptides	41:72	Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides.
32348759	1	12	theme	bacterial	79:87	arg1	wall					94:97	The bacterial cell wall	75:97	The bacterial cell wall	75:97	The bacterial cell wall is made of peptidoglycan (PG), a polymer that is essential for the maintenance of cell shape and survival.
32348759	5	13	theme	non-canonical	829:841	arg1	acids					866:870	canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids	800:870	canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids	800:870	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	3	14	theme	Vibrio	340:345	arg1	cholerae					347:354	Vibrio cholerae	340:354	Vibrio cholerae	340:354	Here, we show that Vibrio cholerae recycles PG fragments modified with non-canonical d-amino acids (NCDAA), which lead to the accumulation of cytosolic PG tetrapeptides.
32348759	5	15	from	accumulation	893:904	arg1	environments					951:962	NCDAA-rich environments	940:962	NCDAA-rich environments	940:962	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	1	16	theme	cell	89:92	arg1	wall					94:97	The bacterial cell wall	75:97	The bacterial cell wall	75:97	The bacterial cell wall is made of peptidoglycan (PG), a polymer that is essential for the maintenance of cell shape and survival.
32348759	5	17	theme	intracellular	909:921	arg1	tetrapeptides					923:935	intracellular tetrapeptides	909:935	intracellular tetrapeptides	909:935	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	3	18	theme	non-canonical	392:404	arg1	NCDAA					421:425	NCDAA	421:425	NCDAA	421:425	Here, we show that Vibrio cholerae recycles PG fragments modified with non-canonical d-amino acids (NCDAA), which lead to the accumulation of cytosolic PG tetrapeptides.
32348759	3	18	theme	non-canonical	392:404	arg1	acids					414:418	non-canonical d-amino acids	392:418	non-canonical d-amino acids (NCDAA)	392:426	Here, we show that Vibrio cholerae recycles PG fragments modified with non-canonical d-amino acids (NCDAA), which lead to the accumulation of cytosolic PG tetrapeptides.
32348759	0	19	theme	Synthesis	28:36	arg1	Modulation					0:9	Modulation	0:9	Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides.	0:73	Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides.
32348759	5	20	theme	tetrapeptides	923:935	arg1	widespread					967:976	widespread	967:976	widespread	967:976	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	5	20	theme	tetrapeptides	923:935	arg1	accumulation					893:904	the accumulation	889:904	the accumulation of intracellular tetrapeptides in NCDAA-rich environments	889:962	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	5	21	theme	NCDAA-rich	940:949	arg1	environments					951:962	NCDAA-rich environments	940:962	NCDAA-rich environments	940:962	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	0	22	theme	Peptidoglycan	14:26	arg1	Synthesis					28:36	Peptidoglycan Synthesis	14:36	Peptidoglycan Synthesis	14:36	Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides.
32348759	5	23	contain	containing	789:798	arg1	substrates					778:787	substrates	778:787	substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids	778:870	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	5	23	contain	containing	789:798	arg2	acids					866:870	canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids	800:870	canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids	800:870	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	4	24	theme	cell	594:597	arg1	wall					599:602	the cell wall	590:602	the cell wall	590:602	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	0	25	theme	Recycled	41:48	arg1	Tetrapeptides					60:72	Recycled Cell Wall Tetrapeptides	41:72	Recycled Cell Wall Tetrapeptides	41:72	Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides.
32348759	4	26	contain	has	554:556	arg2	reduction					605:613	reduction	605:613	reduction of d,d-cross-linkage	605:634	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	4	26	contain	has	554:556	arg2	consequences					573:584	two regulatory consequences	558:584	two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis	558:664	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	4	26	contain	has	554:556	arg1	accumulation					515:526	the accumulation	511:526	the accumulation of recycled tetrapeptides	511:552	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	4	26	contain	has	554:556	arg2	reduction					640:648	reduction	640:648	reduction of PG synthesis	640:664	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	6	27	theme	PG	1046:1047	arg1	recycling					1049:1057	PG recycling	1046:1057	PG recycling	1046:1057	Collectively, this work reveals a regulatory role of NCDAA linking PG recycling and synthesis to promote optimal cell wall assembly and composition in the stationary phase.
32348759	4	28	theme	d	618:618	arg1	consequences					573:584	two regulatory consequences	558:584	two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis	558:664	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	4	28	theme	d	618:618	arg1	reduction					605:613	reduction	605:613	reduction of d,d-cross-linkage	605:634	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	4	28	theme	d	618:618	arg1	reduction					640:648	reduction	640:648	reduction of PG synthesis	640:664	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	1	29	theme	cell	181:184	arg1	maintenance					166:176	the maintenance	162:176	the maintenance of cell shape and survival	162:203	The bacterial cell wall is made of peptidoglycan (PG), a polymer that is essential for the maintenance of cell shape and survival.
32348759	0	30	theme	Wall	55:58	arg1	Tetrapeptides					60:72	Recycled Cell Wall Tetrapeptides	41:72	Recycled Cell Wall Tetrapeptides	41:72	Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides.
32348759	5	31	theme	preferential	752:763	arg1	activity					765:772	a preferential activity	750:772	a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids	750:870	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	6	32	theme	cell	1092:1095	arg1	assembly					1102:1109	optimal cell wall assembly	1084:1109	optimal cell wall assembly	1084:1109	Collectively, this work reveals a regulatory role of NCDAA linking PG recycling and synthesis to promote optimal cell wall assembly and composition in the stationary phase.
32348759	3	33	theme	PG	365:366	arg1	fragments					368:376	PG fragments	365:376	PG fragments modified with non-canonical d-amino acids (NCDAA), which lead to the accumulation of cytosolic PG tetrapeptides	365:488	Here, we show that Vibrio cholerae recycles PG fragments modified with non-canonical d-amino acids (NCDAA), which lead to the accumulation of cytosolic PG tetrapeptides.
32348759	5	34	dep	non-canonical	829:841	arg1	d-methionine					844:855	d-methionine	844:855	d-methionine	844:855	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	4	35	theme	synthesis	656:664	arg1	consequences					573:584	two regulatory consequences	558:584	two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis	558:664	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	4	35	theme	synthesis	656:664	arg1	reduction					605:613	reduction	605:613	reduction of d,d-cross-linkage	605:634	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	4	35	theme	synthesis	656:664	arg1	reduction					640:648	reduction	640:648	reduction of PG synthesis	640:664	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	6	36	theme	regulatory	1013:1022	arg1	role					1024:1027	a regulatory role	1011:1027	a regulatory role of NCDAA linking PG recycling and synthesis to promote optimal cell wall assembly and composition in the stationary phase	1011:1149	Collectively, this work reveals a regulatory role of NCDAA linking PG recycling and synthesis to promote optimal cell wall assembly and composition in the stationary phase.
32348759	4	37	dep	consequences	573:584	arg1	consequences					573:584	two regulatory consequences	558:584	two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis	558:664	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	4	37	dep	consequences	573:584	arg1	reduction					605:613	reduction	605:613	reduction of d,d-cross-linkage	605:634	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	4	37	dep	consequences	573:584	arg1	reduction					640:648	reduction	640:648	reduction of PG synthesis	640:664	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	1	38	dep	cell	181:184	arg1	shape					186:190	shape	186:190	shape	186:190	The bacterial cell wall is made of peptidoglycan (PG), a polymer that is essential for the maintenance of cell shape and survival.
32348759	2	39	dep	remodel	230:236	arg1	releasing					248:256	releasing	248:256	releasing fragments that are predominantly re-internalized and recycled	248:318	During growth, bacteria remodel their PG, releasing fragments that are predominantly re-internalized and recycled.
32348759	4	40	theme	regulatory	562:571	arg1	consequences					573:584	two regulatory consequences	558:584	two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis	558:664	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	4	40	theme	regulatory	562:571	arg1	reduction					605:613	reduction	605:613	reduction of d,d-cross-linkage	605:634	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	4	40	theme	regulatory	562:571	arg1	reduction					640:648	reduction	640:648	reduction of PG synthesis	640:664	We demonstrate that the accumulation of recycled tetrapeptides has two regulatory consequences for the cell wall: reduction of d,d-cross-linkage and reduction of PG synthesis.
32348759	6	41	theme	optimal	1084:1090	arg1	assembly					1102:1109	optimal cell wall assembly	1084:1109	optimal cell wall assembly	1084:1109	Collectively, this work reveals a regulatory role of NCDAA linking PG recycling and synthesis to promote optimal cell wall assembly and composition in the stationary phase.
32348759	5	42	dep	canonical	800:808	arg1	d-alanine					811:819	d-alanine	811:819	d-alanine	811:819	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	5	43	theme	canonical	800:808	arg1	acids					866:870	canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids	800:870	canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids	800:870	We further demonstrate that l,d-carboxypeptidases from five different species show a preferential activity for substrates containing canonical (d-alanine) versus non-canonical (d-methionine) d-amino acids, suggesting that the accumulation of intracellular tetrapeptides in NCDAA-rich environments is widespread.
32348759	3	44	theme	cytosolic	463:471	arg1	tetrapeptides					476:488	cytosolic PG tetrapeptides	463:488	cytosolic PG tetrapeptides	463:488	Here, we show that Vibrio cholerae recycles PG fragments modified with non-canonical d-amino acids (NCDAA), which lead to the accumulation of cytosolic PG tetrapeptides.
32348759	1	45	theme	survival	196:203	arg1	maintenance					166:176	the maintenance	162:176	the maintenance of cell shape and survival	162:203	The bacterial cell wall is made of peptidoglycan (PG), a polymer that is essential for the maintenance of cell shape and survival.
32348759	3	46	theme	PG	473:474	arg1	tetrapeptides					476:488	cytosolic PG tetrapeptides	463:488	cytosolic PG tetrapeptides	463:488	Here, we show that Vibrio cholerae recycles PG fragments modified with non-canonical d-amino acids (NCDAA), which lead to the accumulation of cytosolic PG tetrapeptides.
33592268	5	0	from	decrease	1003:1010	arg1	yields					972:977	the yields	968:977	the yields using Aga_PEI_Gal	968:995	The use of milk whey instead of pure lactose and fructose produced an improvement in the yields using Aga_PEI_Gal and a decrease using Chi_Glu_Gal.
33592268	1	1	theme	different	155:163	arg1	biocatalysts					165:176	3 different biocatalysts	153:176	3 different biocatalysts of β-galactosidase from Kluyveromyces lactis	153:221	In this paper, 3 different biocatalysts of β-galactosidase from Kluyveromyces lactis have been prepared by immobilization in chitosan activated with glutaraldehyde (Chi_Glu_Gal), glyoxyl agarose (Aga_Gly_Gal) and agarose coated with polyethylenimine (Aga_PEI_Gal).
33592268	2	2	from	lactose	481:487	arg1	synthesis					453:461	the synthesis	449:461	the synthesis of lactulose from lactose and fructose	449:500	These biocatalysts have been used to catalyze the synthesis of lactulose from lactose and fructose.
33592268	7	3	theme	β-galactosidase	1195:1209	arg1	performance					1180:1190	the performance	1176:1190	the performance of β-galactosidase	1176:1209	This study reveals how enzyme immobilization may greatly alter the performance of β-galactosidase in a kinetically controlled manner, and how medium composition influences this performance due to the kinetic properties of β-galactosidase.
33592268	7	4	theme	controlled	1228:1237	arg1	manner					1239:1244	a kinetically controlled manner	1214:1244	a kinetically controlled manner	1214:1244	This study reveals how enzyme immobilization may greatly alter the performance of β-galactosidase in a kinetically controlled manner, and how medium composition influences this performance due to the kinetic properties of β-galactosidase.
33592268	3	5	theme	assayed	696:702	arg1	temperatures					704:715	all assayed temperatures	692:715	all assayed temperatures	692:715	Aga-PEI-Gal only produces lactulose at 50 °C, and not at 25 or 37 °C, Aga_Gly_Gal was unable to produce lactulose at any of the assayed temperatures while Chi_Glu_Gal produced lactulose at all assayed temperatures, although a lower yield was obtained at 25 or 37 °C.
33592268	0	6	theme	controlled	103:112	arg1	synthesis					114:122	the kinetically controlled synthesis	87:122	the kinetically controlled synthesis of lactulose	87:135	The β-galactosidase immobilization protocol determines its performance as catalysts in the kinetically controlled synthesis of lactulose.
33592268	3	7	theme	lower	729:733	arg1	yield					735:739	a lower yield	727:739	a lower yield	727:739	Aga-PEI-Gal only produces lactulose at 50 °C, and not at 25 or 37 °C, Aga_Gly_Gal was unable to produce lactulose at any of the assayed temperatures while Chi_Glu_Gal produced lactulose at all assayed temperatures, although a lower yield was obtained at 25 or 37 °C.
33592268	0	8	theme	lactulose	127:135	arg1	synthesis					114:122	the kinetically controlled synthesis	87:122	the kinetically controlled synthesis of lactulose	87:135	The β-galactosidase immobilization protocol determines its performance as catalysts in the kinetically controlled synthesis of lactulose.
33592268	4	9	theme	similar	838:844	arg1	yields					846:851	similar yields	838:851	similar yields	838:851	The pre-incubation of this biocatalyst at 50 °C permitted to obtain similar yields at 25 or 37 °C than at 50 °C.
33592268	7	10	theme	kinetic	1313:1319	arg1	properties					1321:1330	the kinetic properties	1309:1330	the kinetic properties of β-galactosidase	1309:1349	This study reveals how enzyme immobilization may greatly alter the performance of β-galactosidase in a kinetically controlled manner, and how medium composition influences this performance due to the kinetic properties of β-galactosidase.
33592268	2	11	from	fructose	493:500	arg1	synthesis					453:461	the synthesis	449:461	the synthesis of lactulose from lactose and fructose	449:500	These biocatalysts have been used to catalyze the synthesis of lactulose from lactose and fructose.
33592268	3	12	from	any	620:622	arg1	lactulose					607:615	lactulose	607:615	lactulose at any of the assayed temperatures	607:650	Aga-PEI-Gal only produces lactulose at 50 °C, and not at 25 or 37 °C, Aga_Gly_Gal was unable to produce lactulose at any of the assayed temperatures while Chi_Glu_Gal produced lactulose at all assayed temperatures, although a lower yield was obtained at 25 or 37 °C.
33592268	1	13	theme	β-galactosidase	181:195	arg1	biocatalysts					165:176	3 different biocatalysts	153:176	3 different biocatalysts of β-galactosidase from Kluyveromyces lactis	153:221	In this paper, 3 different biocatalysts of β-galactosidase from Kluyveromyces lactis have been prepared by immobilization in chitosan activated with glutaraldehyde (Chi_Glu_Gal), glyoxyl agarose (Aga_Gly_Gal) and agarose coated with polyethylenimine (Aga_PEI_Gal).
33592268	0	14	theme	β-galactosidase	4:18	arg1	protocol					35:42	The β-galactosidase immobilization protocol	0:42	The β-galactosidase immobilization protocol	0:42	The β-galactosidase immobilization protocol determines its performance as catalysts in the kinetically controlled synthesis of lactulose.
33592268	6	15	theme	operational	1035:1045	arg1	stability					1047:1055	The operational stability	1031:1055	The operational stability	1031:1055	The operational stability also depends on the reaction medium and of biocatalyst.
33592268	7	16	dep	reveals	1124:1130	arg1	influences					1274:1283	influences	1274:1283	influences this performance due to the kinetic properties of β-galactosidase	1274:1349	This study reveals how enzyme immobilization may greatly alter the performance of β-galactosidase in a kinetically controlled manner, and how medium composition influences this performance due to the kinetic properties of β-galactosidase.
33592268	7	16	dep	reveals	1124:1130	arg1	alter					1170:1174	alter	1170:1174	may greatly alter the performance of β-galactosidase in a kinetically controlled manner	1158:1244	This study reveals how enzyme immobilization may greatly alter the performance of β-galactosidase in a kinetically controlled manner, and how medium composition influences this performance due to the kinetic properties of β-galactosidase.
33592268	5	17	theme	pure	915:918	arg1	lactose					920:926	pure lactose	915:926	pure lactose	915:926	The use of milk whey instead of pure lactose and fructose produced an improvement in the yields using Aga_PEI_Gal and a decrease using Chi_Glu_Gal.
33592268	0	18	theme	immobilization	20:33	arg1	protocol					35:42	The β-galactosidase immobilization protocol	0:42	The β-galactosidase immobilization protocol	0:42	The β-galactosidase immobilization protocol determines its performance as catalysts in the kinetically controlled synthesis of lactulose.
33592268	4	19	from	50 °C	812:816	arg1	pre-incubation					774:787	The pre-incubation	770:787	The pre-incubation of this biocatalyst at 50 °C	770:816	The pre-incubation of this biocatalyst at 50 °C permitted to obtain similar yields at 25 or 37 °C than at 50 °C.
33592268	7	20	theme	due	1302:1304	arg1	performance					1290:1300	this performance	1285:1300	this performance due to the kinetic properties of β-galactosidase	1285:1349	This study reveals how enzyme immobilization may greatly alter the performance of β-galactosidase in a kinetically controlled manner, and how medium composition influences this performance due to the kinetic properties of β-galactosidase.
33592268	1	21	theme	glyoxyl	317:323	arg1	Aga_Gly_Gal					334:344	Aga_Gly_Gal	334:344	Aga_Gly_Gal	334:344	In this paper, 3 different biocatalysts of β-galactosidase from Kluyveromyces lactis have been prepared by immobilization in chitosan activated with glutaraldehyde (Chi_Glu_Gal), glyoxyl agarose (Aga_Gly_Gal) and agarose coated with polyethylenimine (Aga_PEI_Gal).
33592268	1	21	theme	glyoxyl	317:323	arg1	agarose					325:331	glyoxyl agarose	317:331	glyoxyl agarose (Aga_Gly_Gal)	317:345	In this paper, 3 different biocatalysts of β-galactosidase from Kluyveromyces lactis have been prepared by immobilization in chitosan activated with glutaraldehyde (Chi_Glu_Gal), glyoxyl agarose (Aga_Gly_Gal) and agarose coated with polyethylenimine (Aga_PEI_Gal).
33592268	3	22	theme	assayed	631:637	arg1	temperatures					639:650	the assayed temperatures	627:650	the assayed temperatures	627:650	Aga-PEI-Gal only produces lactulose at 50 °C, and not at 25 or 37 °C, Aga_Gly_Gal was unable to produce lactulose at any of the assayed temperatures while Chi_Glu_Gal produced lactulose at all assayed temperatures, although a lower yield was obtained at 25 or 37 °C.
33592268	2	23	used	used	432:435	arg2	biocatalysts					409:420	These biocatalysts	403:420	These biocatalysts	403:420	These biocatalysts have been used to catalyze the synthesis of lactulose from lactose and fructose.
33592268	7	24	theme	medium	1255:1260	arg1	composition					1262:1272	medium composition	1255:1272	medium composition	1255:1272	This study reveals how enzyme immobilization may greatly alter the performance of β-galactosidase in a kinetically controlled manner, and how medium composition influences this performance due to the kinetic properties of β-galactosidase.
33592268	1	25	from	lactis	216:221	arg1	biocatalysts					165:176	3 different biocatalysts	153:176	3 different biocatalysts of β-galactosidase from Kluyveromyces lactis	153:221	In this paper, 3 different biocatalysts of β-galactosidase from Kluyveromyces lactis have been prepared by immobilization in chitosan activated with glutaraldehyde (Chi_Glu_Gal), glyoxyl agarose (Aga_Gly_Gal) and agarose coated with polyethylenimine (Aga_PEI_Gal).
33592268	7	26	theme	β-galactosidase	1335:1349	arg1	properties					1321:1330	the kinetic properties	1309:1330	the kinetic properties of β-galactosidase	1309:1349	This study reveals how enzyme immobilization may greatly alter the performance of β-galactosidase in a kinetically controlled manner, and how medium composition influences this performance due to the kinetic properties of β-galactosidase.
33592268	5	27	theme	milk	894:897	arg1	whey					899:902	milk whey	894:902	milk whey	894:902	The use of milk whey instead of pure lactose and fructose produced an improvement in the yields using Aga_PEI_Gal and a decrease using Chi_Glu_Gal.
33592268	5	28	theme	whey	899:902	arg1	use					887:889	The use	883:889	The use of milk whey	883:902	The use of milk whey instead of pure lactose and fructose produced an improvement in the yields using Aga_PEI_Gal and a decrease using Chi_Glu_Gal.
33592268	5	29	from	improvement	953:963	arg1	yields					972:977	the yields	968:977	the yields using Aga_PEI_Gal	968:995	The use of milk whey instead of pure lactose and fructose produced an improvement in the yields using Aga_PEI_Gal and a decrease using Chi_Glu_Gal.
33592268	4	30	theme	biocatalyst	797:807	arg1	pre-incubation					774:787	The pre-incubation	770:787	The pre-incubation of this biocatalyst at 50 °C	770:816	The pre-incubation of this biocatalyst at 50 °C permitted to obtain similar yields at 25 or 37 °C than at 50 °C.
33592268	6	31	theme	reaction	1077:1084	arg1	medium					1086:1091	the reaction medium	1073:1091	the reaction medium	1073:1091	The operational stability also depends on the reaction medium and of biocatalyst.
33592268	7	32	theme	enzyme	1136:1141	arg1	immobilization					1143:1156	enzyme immobilization	1136:1156	enzyme immobilization	1136:1156	This study reveals how enzyme immobilization may greatly alter the performance of β-galactosidase in a kinetically controlled manner, and how medium composition influences this performance due to the kinetic properties of β-galactosidase.
33592268	2	33	theme	lactulose	466:474	arg1	synthesis					453:461	the synthesis	449:461	the synthesis of lactulose from lactose and fructose	449:500	These biocatalysts have been used to catalyze the synthesis of lactulose from lactose and fructose.
34464859	3	0	theme	crystalized	927:937	arg1	Ti-nanostructures					891:907	Ti-nanostructures	891:907	Ti-nanostructures	891:907	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	8	1	theme	supporting	1791:1800	arg1	capacity					1802:1809	the good supporting capacity	1782:1809	Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution	1753:1857	This performance originates from the adsorption by mutated graphene-like carbon and assisted photocatalysis by Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution.
34464859	2	2	theme	Carbon	587:592	arg1	"					618:618	Activated Carbon Nanostructures (Ti-ACNs)"	577:618	Activated Carbon Nanostructures (Ti-ACNs)"	577:618	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	3	theme	Titanium	670:677	arg1	"					642:642	"Nanocellulose (NCel)"	621:642	"Nanocellulose (NCel)"	621:642	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	3	theme	Titanium	670:677	arg1	combination					649:659	combination	649:659	combination	649:659	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	3	theme	Titanium	670:677	arg1	"					618:618	Activated Carbon Nanostructures (Ti-ACNs)"	577:618	Activated Carbon Nanostructures (Ti-ACNs)"	577:618	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	5	4	theme	Crystal	1342:1348	arg1	Violet					1350:1355	Crystal Violet	1342:1355	Crystal Violet	1342:1355	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC) have demonstrated rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater through surface adsorption and photocatalysis.
34464859	5	4	theme	Crystal	1342:1348	arg1	Violet					1365:1370	Methyl Violet	1358:1370	Methyl Violet	1358:1370	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC) have demonstrated rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater through surface adsorption and photocatalysis.
34464859	1	5	theme	materials	190:198	arg1	Production					151:160	Production	151:160	Production of cost-efficient composite materials with desired physicochemical properties from low-cost waste material	151:267	Production of cost-efficient composite materials with desired physicochemical properties from low-cost waste material is much needed to meet the growing needs of the industrial sector.
34464859	2	6	dep	Doped	571:575	arg1	fall					474:477	fall	474:477	fall	474:477	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	1	7	theme	desired	205:211	arg1	properties					229:238	desired physicochemical properties	205:238	desired physicochemical properties from low-cost waste material	205:267	Production of cost-efficient composite materials with desired physicochemical properties from low-cost waste material is much needed to meet the growing needs of the industrial sector.
34464859	2	8	theme	Cellulose	702:710	arg1	"					740:740	Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)"	685:740	Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)"	685:740	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	8	9	theme	homogenous	1827:1836	arg1	distribution					1846:1857	the homogenous Ti-ACNs distribution	1823:1857	the homogenous Ti-ACNs distribution	1823:1857	This performance originates from the adsorption by mutated graphene-like carbon and assisted photocatalysis by Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution.
34464859	2	10	theme	Activated	685:693	arg1	"					740:740	Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)"	685:740	Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)"	685:740	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	8	11	theme	graphene-like	1701:1713	arg1	carbon					1715:1720	mutated graphene-like carbon	1693:1720	mutated graphene-like carbon	1693:1720	This performance originates from the adsorption by mutated graphene-like carbon and assisted photocatalysis by Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution.
34464859	0	12	theme	organic	131:137	arg1	pollutants					139:148	organic pollutants	131:148	organic pollutants	131:148	Transformation of industrial and organic waste into titanium doped activated carbon - cellulose nanocomposite for rapid removal of organic pollutants.
34464859	1	13	theme	low-cost	245:252	arg1	material					260:267	low-cost waste material	245:267	low-cost waste material	245:267	Production of cost-efficient composite materials with desired physicochemical properties from low-cost waste material is much needed to meet the growing needs of the industrial sector.
34464859	2	14	theme	nanomaterials	529:541	arg1	types					520:524	three types	514:524	three types of nanomaterials at the same time	514:558	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	1	15	dep	the	292:294	arg1	needs					304:308	needs	304:308	needs	304:308	Production of cost-efficient composite materials with desired physicochemical properties from low-cost waste material is much needed to meet the growing needs of the industrial sector.
34464859	1	16	from	material	260:267	arg1	properties					229:238	desired physicochemical properties	205:238	desired physicochemical properties from low-cost waste material	205:267	Production of cost-efficient composite materials with desired physicochemical properties from low-cost waste material is much needed to meet the growing needs of the industrial sector.
34464859	6	17	theme	pollutants	1499:1508	arg1	pollutants					1499:1508	the organic pollutants	1487:1508	the organic pollutants	1487:1508	In the first 20 min, Ti-ACNs have adsorbed ≈87% of the organic pollutants and further photocatalyzed them up to ≈96%.
34464859	6	17	theme	pollutants	1499:1508	arg1	%					1482:1482	≈87%	1479:1482	≈87% of the organic pollutants	1479:1508	In the first 20 min, Ti-ACNs have adsorbed ≈87% of the organic pollutants and further photocatalyzed them up to ≈96%.
34464859	0	18	theme	industrial	18:27	arg1	waste					41:45	industrial and organic waste	18:45	industrial and organic waste	18:45	Transformation of industrial and organic waste into titanium doped activated carbon - cellulose nanocomposite for rapid removal of organic pollutants.
34464859	4	19	dep	Fourier	1045:1051	arg1	transform					1053:1061	transform	1053:1061	transform infrared spectroscopy (micro-FTIR)	1053:1096	Micro- Fourier transform infrared spectroscopy (micro-FTIR) confirms that the chemical structure of NCel with bond vibrations between 1035 to 2917 cm-1 remained preserved during Ti-AC-Cel-NC formation.
34464859	3	20	theme	diffraction	749:759	arg1	measurements					832:843	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements	743:843	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements	743:843	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	0	21	theme	carbon	77:82	arg1	nanocomposite					96:108	carbon - cellulose nanocomposite	77:108	nanocomposite	96:108	Transformation of industrial and organic waste into titanium doped activated carbon - cellulose nanocomposite for rapid removal of organic pollutants.
34464859	1	22	theme	cost-efficient	165:178	arg1	materials					190:198	cost-efficient composite materials	165:198	cost-efficient composite materials	165:198	Production of cost-efficient composite materials with desired physicochemical properties from low-cost waste material is much needed to meet the growing needs of the industrial sector.
34464859	3	23	theme	electron	781:788	arg1	microscopy					790:799	transmission electron microscopy	768:799	transmission electron microscopy (TEM)	768:805	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	3	23	theme	electron	781:788	arg1	TEM					802:804	TEM	802:804	TEM	802:804	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	2	24	theme	Ti-ACNs	610:616	arg1	"					618:618	Activated Carbon Nanostructures (Ti-ACNs)"	577:618	Activated Carbon Nanostructures (Ti-ACNs)"	577:618	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	0	25	theme	cellulose	86:94	arg1	nanocomposite					96:108	carbon - cellulose nanocomposite	77:108	nanocomposite	96:108	Transformation of industrial and organic waste into titanium doped activated carbon - cellulose nanocomposite for rapid removal of organic pollutants.
34464859	1	26	with	Production	151:160	arg1	properties					229:238	desired physicochemical properties	205:238	desired physicochemical properties from low-cost waste material	205:267	Production of cost-efficient composite materials with desired physicochemical properties from low-cost waste material is much needed to meet the growing needs of the industrial sector.
34464859	8	27	theme	Ti	1753:1754	arg1	nanostructures					1756:1769	Ti nanostructures	1753:1769	Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution	1753:1857	This performance originates from the adsorption by mutated graphene-like carbon and assisted photocatalysis by Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution.
34464859	3	28	theme	microanalysis	811:823	arg1	measurements					832:843	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements	743:843	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements	743:843	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	2	29	theme	Nanostructures	594:607	arg1	"					618:618	Activated Carbon Nanostructures (Ti-ACNs)"	577:618	Activated Carbon Nanostructures (Ti-ACNs)"	577:618	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	30	theme	inorganic	446:454	arg1	waste					457:461	industrial metal (inorganic) waste	428:461	industrial metal (inorganic) waste	428:461	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	31	theme	metal	439:443	arg1	waste					457:461	industrial metal (inorganic) waste	428:461	industrial metal (inorganic) waste	428:461	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	4	32	theme	NCel	1138:1141	arg1	structure					1125:1133	the chemical structure	1112:1133	the chemical structure of NCel with bond vibrations between 1035 to 2917 cm-1	1112:1188	Micro- Fourier transform infrared spectroscopy (micro-FTIR) confirms that the chemical structure of NCel with bond vibrations between 1035 to 2917 cm-1 remained preserved during Ti-AC-Cel-NC formation.
34464859	5	33	theme	prepared	1244:1251	arg1	materials					1253:1261	The prepared materials	1240:1261	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC)	1240:1285	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC) have demonstrated rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater through surface adsorption and photocatalysis.
34464859	5	33	theme	prepared	1244:1251	arg1	Ti-AC-Cel-NC					1273:1284	Ti-AC-Cel-NC	1273:1284	Ti-AC-Cel-NC	1273:1284	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC) have demonstrated rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater through surface adsorption and photocatalysis.
34464859	6	34	theme	organic	1491:1497	arg1	pollutants					1499:1508	the organic pollutants	1487:1508	the organic pollutants	1487:1508	In the first 20 min, Ti-ACNs have adsorbed ≈87% of the organic pollutants and further photocatalyzed them up to ≈96%.
34464859	4	35	theme	Micro-	1038:1043	arg1	Fourier					1045:1051	Micro- Fourier	1038:1051	Micro- Fourier transform infrared spectroscopy (micro-FTIR)	1038:1096	Micro- Fourier transform infrared spectroscopy (micro-FTIR) confirms that the chemical structure of NCel with bond vibrations between 1035 to 2917 cm-1 remained preserved during Ti-AC-Cel-NC formation.
34464859	2	36	theme	effective	403:411	arg1	forward					346:352	a step forward	339:352	a step forward	339:352	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	36	theme	effective	403:411	arg1	utilization					413:423	an effective utilization	400:423	an effective utilization of industrial metal (inorganic) waste	400:461	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	0	37	theme	organic	33:39	arg1	waste					41:45	industrial and organic waste	18:45	industrial and organic waste	18:45	Transformation of industrial and organic waste into titanium doped activated carbon - cellulose nanocomposite for rapid removal of organic pollutants.
34464859	1	38	theme	industrial	317:326	arg1	sector					328:333	the industrial sector	313:333	the industrial sector	313:333	Production of cost-efficient composite materials with desired physicochemical properties from low-cost waste material is much needed to meet the growing needs of the industrial sector.
34464859	3	39	theme	graphene	1021:1028	arg1	clouds					1030:1035	mutated graphene clouds	1013:1035	mutated graphene clouds	1013:1035	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	3	40	theme	Ti-ACNs	861:867	arg1	material					869:876	the Ti-ACNs material	857:876	the Ti-ACNs material	857:876	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	2	41	theme	waste	457:461	arg1	forward					346:352	a step forward	339:352	a step forward	339:352	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	41	theme	waste	457:461	arg1	utilization					413:423	an effective utilization	400:423	an effective utilization of industrial metal (inorganic) waste	400:461	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	4	42	dep	transform	1053:1061	arg1	infrared					1063:1070	infrared	1063:1070	transform infrared spectroscopy (micro-FTIR)	1053:1096	Micro- Fourier transform infrared spectroscopy (micro-FTIR) confirms that the chemical structure of NCel with bond vibrations between 1035 to 2917 cm-1 remained preserved during Ti-AC-Cel-NC formation.
34464859	5	43	theme	organic	1322:1328	arg1	pollutants					1330:1339	organic pollutants	1322:1339	organic pollutants (Crystal Violet, Methyl Violet)	1322:1371	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC) have demonstrated rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater through surface adsorption and photocatalysis.
34464859	2	44	theme	step	341:344	arg1	forward					346:352	a step forward	339:352	a step forward	339:352	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	44	theme	step	341:344	arg1	utilization					413:423	an effective utilization	400:423	an effective utilization of industrial metal (inorganic) waste	400:461	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	1	45	theme	waste	254:258	arg1	material					260:267	low-cost waste material	245:267	low-cost waste material	245:267	Production of cost-efficient composite materials with desired physicochemical properties from low-cost waste material is much needed to meet the growing needs of the industrial sector.
34464859	2	46	theme	Ti-AC-Cel-NC	727:738	arg1	"					740:740	Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)"	685:740	Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)"	685:740	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	5	47	from	wastewater	1378:1387	arg1	removal					1311:1317	rapid removal	1305:1317	rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater	1305:1387	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC) have demonstrated rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater through surface adsorption and photocatalysis.
34464859	8	48	theme	good	1786:1789	arg1	capacity					1802:1809	the good supporting capacity	1782:1809	Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution	1753:1857	This performance originates from the adsorption by mutated graphene-like carbon and assisted photocatalysis by Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution.
34464859	2	49	theme	current	359:365	arg1	study					367:371	the current study	355:371	the current study	355:371	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	50	theme	same	550:553	arg1	time					555:558	the same time	546:558	the same time	546:558	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	8	51	theme	NCel	1814:1817	arg1	capacity					1802:1809	the good supporting capacity	1782:1809	Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution	1753:1857	This performance originates from the adsorption by mutated graphene-like carbon and assisted photocatalysis by Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution.
34464859	8	51	theme	NCel	1814:1817	arg1	nanostructures					1756:1769	Ti nanostructures	1753:1769	Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution	1753:1857	This performance originates from the adsorption by mutated graphene-like carbon and assisted photocatalysis by Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution.
34464859	1	52	theme	composite	180:188	arg1	materials					190:198	cost-efficient composite materials	165:198	cost-efficient composite materials	165:198	Production of cost-efficient composite materials with desired physicochemical properties from low-cost waste material is much needed to meet the growing needs of the industrial sector.
34464859	2	53	theme	Activated	577:585	arg1	"					618:618	Activated Carbon Nanostructures (Ti-ACNs)"	577:618	Activated Carbon Nanostructures (Ti-ACNs)"	577:618	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	54	theme	Nanocomposite	712:724	arg1	"					740:740	Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)"	685:740	Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)"	685:740	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	8	55	theme	Ti-ACNs	1838:1844	arg1	distribution					1846:1857	the homogenous Ti-ACNs distribution	1823:1857	the homogenous Ti-ACNs distribution	1823:1857	This performance originates from the adsorption by mutated graphene-like carbon and assisted photocatalysis by Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution.
34464859	5	56	theme	Methyl	1358:1363	arg1	Violet					1350:1355	Crystal Violet	1342:1355	Crystal Violet	1342:1355	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC) have demonstrated rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater through surface adsorption and photocatalysis.
34464859	5	56	theme	Methyl	1358:1363	arg1	Violet					1365:1370	Methyl Violet	1358:1370	Methyl Violet	1358:1370	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC) have demonstrated rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater through surface adsorption and photocatalysis.
34464859	1	57	theme	physicochemical	213:227	arg1	properties					229:238	desired physicochemical properties	205:238	desired physicochemical properties from low-cost waste material	205:267	Production of cost-efficient composite materials with desired physicochemical properties from low-cost waste material is much needed to meet the growing needs of the industrial sector.
34464859	3	58	from	embedded	1001:1008	arg1	clouds					1030:1035	mutated graphene clouds	1013:1035	mutated graphene clouds	1013:1035	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	2	59	theme	Carbon	695:700	arg1	"					740:740	Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)"	685:740	Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)"	685:740	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	0	60	theme	pollutants	139:148	arg1	removal					120:126	rapid removal	114:126	rapid removal of organic pollutants	114:148	Transformation of industrial and organic waste into titanium doped activated carbon - cellulose nanocomposite for rapid removal of organic pollutants.
34464859	6	61	theme	first	1443:1447	arg1	20 min					1449:1454	the first 20 min	1439:1454	the first 20 min	1439:1454	In the first 20 min, Ti-ACNs have adsorbed ≈87% of the organic pollutants and further photocatalyzed them up to ≈96%.
34464859	4	62	with	NCel	1138:1141	arg1	vibrations					1153:1162	bond vibrations	1148:1162	bond vibrations between 1035 to 2917 cm-1	1148:1188	Micro- Fourier transform infrared spectroscopy (micro-FTIR) confirms that the chemical structure of NCel with bond vibrations between 1035 to 2917 cm-1 remained preserved during Ti-AC-Cel-NC formation.
34464859	4	63	theme	chemical	1116:1123	arg1	structure					1125:1133	the chemical structure	1112:1133	the chemical structure of NCel with bond vibrations between 1035 to 2917 cm-1	1112:1188	Micro- Fourier transform infrared spectroscopy (micro-FTIR) confirms that the chemical structure of NCel with bond vibrations between 1035 to 2917 cm-1 remained preserved during Ti-AC-Cel-NC formation.
34464859	4	64	theme	bond	1148:1151	arg1	vibrations					1153:1162	bond vibrations	1148:1162	bond vibrations between 1035 to 2917 cm-1	1148:1188	Micro- Fourier transform infrared spectroscopy (micro-FTIR) confirms that the chemical structure of NCel with bond vibrations between 1035 to 2917 cm-1 remained preserved during Ti-AC-Cel-NC formation.
34464859	3	65	theme	transmission	768:779	arg1	microscopy					790:799	transmission electron microscopy	768:799	transmission electron microscopy (TEM)	768:805	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	3	65	theme	transmission	768:779	arg1	TEM					802:804	TEM	802:804	TEM	802:804	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	8	66	theme	mutated	1693:1699	arg1	carbon					1715:1720	mutated graphene-like carbon	1693:1720	mutated graphene-like carbon	1693:1720	This performance originates from the adsorption by mutated graphene-like carbon and assisted photocatalysis by Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution.
34464859	4	67	dep	2917 cm-1	1180:1188	arg1	to					1177:1178	to	1177:1178	to	1177:1178	Micro- Fourier transform infrared spectroscopy (micro-FTIR) confirms that the chemical structure of NCel with bond vibrations between 1035 to 2917 cm-1 remained preserved during Ti-AC-Cel-NC formation.
34464859	3	68	theme	hexagonal	965:973	arg1	Ti-crystallites					975:989	hexagonal Ti-crystallites	965:989	hexagonal Ti-crystallites	965:989	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	8	69	theme	assisted	1726:1733	arg1	photocatalysis					1735:1748	assisted photocatalysis	1726:1748	assisted photocatalysis	1726:1748	This performance originates from the adsorption by mutated graphene-like carbon and assisted photocatalysis by Ti nanostructures as well as the good supporting capacity of NCel for the homogenous Ti-ACNs distribution.
34464859	3	70	theme	microscopy	790:799	arg1	measurements					832:843	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements	743:843	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements	743:843	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	3	71	from	clouds	1030:1035	arg1	embedded					1001:1008	embedded	1001:1008	embedded	1001:1008	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	3	72	theme	X-ray	743:747	arg1	XRD					762:764	XRD	762:764	XRD	762:764	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	3	72	theme	X-ray	743:747	arg1	diffraction					749:759	X-ray diffraction	743:759	X-ray diffraction (XRD)	743:765	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	0	73	theme	rapid	114:118	arg1	removal					120:126	rapid removal	114:126	rapid removal of organic pollutants	114:148	Transformation of industrial and organic waste into titanium doped activated carbon - cellulose nanocomposite for rapid removal of organic pollutants.
34464859	5	74	dep	pollutants	1330:1339	arg1	Violet					1350:1355	Crystal Violet	1342:1355	Crystal Violet	1342:1355	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC) have demonstrated rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater through surface adsorption and photocatalysis.
34464859	5	74	dep	pollutants	1330:1339	arg1	Violet					1365:1370	Methyl Violet	1358:1370	Methyl Violet	1358:1370	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC) have demonstrated rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater through surface adsorption and photocatalysis.
34464859	3	75	theme	embedded	1001:1008	arg1	Ti-crystallites					975:989	hexagonal Ti-crystallites	965:989	hexagonal Ti-crystallites	965:989	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	2	76	theme	organic	487:493	arg1	leaves					479:484	leaves	479:484	leaves	479:484	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	76	theme	organic	487:493	arg1	waste					495:499	organic waste	487:499	organic waste	487:499	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	5	77	theme	surface	1397:1403	arg1	adsorption					1405:1414	surface adsorption	1397:1414	surface adsorption	1397:1414	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC) have demonstrated rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater through surface adsorption and photocatalysis.
34464859	2	78	theme	Nanocellulose	622:634	arg1	"					642:642	"Nanocellulose (NCel)"	621:642	"Nanocellulose (NCel)"	621:642	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	79	theme	first	389:393	arg1	time					395:398	the first time	385:398	the first time	385:398	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	3	80	theme	15 nm	994:998	arg1	Ti-crystallites					975:989	hexagonal Ti-crystallites	965:989	hexagonal Ti-crystallites	965:989	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	6	81	dep	≈96	1548:1550	arg1	to					1545:1546	to	1545:1546	to	1545:1546	In the first 20 min, Ti-ACNs have adsorbed ≈87% of the organic pollutants and further photocatalyzed them up to ≈96%.
34464859	2	82	from	time	555:558	arg1	nanomaterials					529:541	nanomaterials	529:541	nanomaterials at the same time	529:558	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	82	from	time	555:558	arg1	types					520:524	three types	514:524	three types of nanomaterials at the same time	514:558	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	2	83	theme	industrial	428:437	arg1	waste					457:461	industrial metal (inorganic) waste	428:461	industrial metal (inorganic) waste	428:461	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	4	84	theme	Ti-AC-Cel-NC	1216:1227	arg1	formation					1229:1237	Ti-AC-Cel-NC formation	1216:1237	Ti-AC-Cel-NC formation	1216:1237	Micro- Fourier transform infrared spectroscopy (micro-FTIR) confirms that the chemical structure of NCel with bond vibrations between 1035 to 2917 cm-1 remained preserved during Ti-AC-Cel-NC formation.
34464859	0	85	theme	waste	41:45	arg1	Transformation					0:13	Transformation	0:13	Transformation of industrial and organic waste into titanium doped	0:65	Transformation of industrial and organic waste into titanium doped activated carbon - cellulose nanocomposite for rapid removal of organic pollutants.
34464859	3	86	theme	mutated	1013:1019	arg1	clouds					1030:1035	mutated graphene clouds	1013:1035	mutated graphene clouds	1013:1035	X-ray diffraction (XRD), transmission electron microscopy (TEM) and microanalysis (EDXS) measurements reveal that the Ti-ACNs material is formed by Ti-nanostructures, generally poorly crystalized but in some cases forming hexagonal Ti-crystallites of 15 nm, embedded in mutated graphene clouds.
34464859	5	87	theme	pollutants	1330:1339	arg1	removal					1311:1317	rapid removal	1305:1317	rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater	1305:1387	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC) have demonstrated rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater through surface adsorption and photocatalysis.
34464859	2	88	from	types	520:524	arg1	time					555:558	the same time	546:558	the same time	546:558	As a step forward, the current study reports for the first time an effective utilization of industrial metal (inorganic) waste as well as fall leaves (organic waste), to produce three types of nanomaterials at the same time; "Titanium Doped Activated Carbon Nanostructures (Ti-ACNs)", "Nanocellulose (NCel)", and combination of both "Titanium Doped Activated Carbon Cellulose Nanocomposite (Ti-AC-Cel-NC)".
34464859	5	89	theme	rapid	1305:1309	arg1	removal					1311:1317	rapid removal	1305:1317	rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater	1305:1387	The prepared materials (Ti-ACNs, Ti-AC-Cel-NC) have demonstrated rapid removal of organic pollutants (Crystal Violet, Methyl Violet) from wastewater through surface adsorption and photocatalysis.
33205506	4	0	theme	water-insoluble	621:635	arg1	acrylates					643:651	water-soluble and water-insoluble (meth)acrylates	603:651	acrylates	643:651	This modification worked with a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides, grafting up to 45 wt% polymer on to the CNFs.
33205506	1	1	theme	water-based	252:262	arg1	system					264:269	an entirely water-based system	240:269	an entirely water-based system	240:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	0	2	theme	Methacrylate	85:96	arg1	Group					98:102	a Reactive Methacrylate Group	74:102	a Reactive Methacrylate Group	74:102	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through a Reactive Methacrylate Group.
33205506	6	3	theme	polymer	958:964	arg1	grafting					966:973	polymer grafting	958:973	polymer grafting	958:973	Soxhlet extraction of modified samples demonstrates that the reactive methacrylate group is necessary to facilitate polymer grafting.
33205506	7	4	theme	electron	1189:1196	arg1	combination					1156:1166	a combination	1154:1166	a combination of optical, scanning electron, and atomic force microscopy	1154:1225	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	7	5	theme	polymers	1015:1022	arg1	functionalization					990:1006	functionalization	990:1006	functionalization of the polymers	990:1022	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	8	6	theme	fibril	1313:1318	arg1	morphology					1320:1329	the micrometer-scale fibril morphology	1292:1329	the micrometer-scale fibril morphology	1292:1329	High levels of polymer modification do not significantly affect the micrometer-scale fibril morphology.
33205506	7	7	theme	optical	1171:1177	arg1	electron					1189:1196	optical, scanning electron, and atomic force microscopy	1171:1225	electron	1189:1196	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	6	8	theme	Soxhlet	842:848	arg1	extraction					850:859	Soxhlet extraction	842:859	Soxhlet extraction of modified samples	842:879	Soxhlet extraction of modified samples demonstrates that the reactive methacrylate group is necessary to facilitate polymer grafting.
33205506	4	9	theme	45 wt	691:695	arg1	polymer					698:704	45 wt% polymer	691:704	45 wt% polymer	691:704	This modification worked with a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides, grafting up to 45 wt% polymer on to the CNFs.
33205506	4	10	theme	acrylates	643:651	arg1	acrylates					643:651	water-soluble and water-insoluble (meth)acrylates	603:651	acrylates	643:651	This modification worked with a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides, grafting up to 45 wt% polymer on to the CNFs.
33205506	4	10	theme	acrylates	643:651	arg1	acrylamides					663:673	(meth)acrylamides	657:673	(meth)acrylamides	657:673	This modification worked with a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides, grafting up to 45 wt% polymer on to the CNFs.
33205506	4	10	theme	acrylates	643:651	arg1	variety					592:598	a variety	590:598	a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides	590:673	This modification worked with a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides, grafting up to 45 wt% polymer on to the CNFs.
33205506	6	11	theme	reactive	903:910	arg1	necessary					934:942	necessary	934:942	necessary	934:942	Soxhlet extraction of modified samples demonstrates that the reactive methacrylate group is necessary to facilitate polymer grafting.
33205506	6	11	theme	reactive	903:910	arg1	group					925:929	the reactive methacrylate group	899:929	the reactive methacrylate group	899:929	Soxhlet extraction of modified samples demonstrates that the reactive methacrylate group is necessary to facilitate polymer grafting.
33205506	8	12	theme	polymer	1243:1249	arg1	modification					1251:1262	polymer modification	1243:1262	polymer modification	1243:1262	High levels of polymer modification do not significantly affect the micrometer-scale fibril morphology.
33205506	5	13	theme	methacrylate	762:773	arg1	group					786:790	the methacrylate functional group	758:790	the methacrylate functional group	758:790	The reaction conditions introducing the methacrylate functional group are adjusted to vary the degree of functionality.
33205506	8	14	theme	modification	1251:1262	arg1	levels					1233:1238	High levels	1228:1238	High levels of polymer modification	1228:1262	High levels of polymer modification do not significantly affect the micrometer-scale fibril morphology.
33205506	1	15	theme	mechanical	171:180	arg1	refinement					182:191	mechanical refinement	171:191	mechanical refinement with a variety of polymer functional groups in an entirely water-based system	171:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	5	16	theme	functional	775:784	arg1	group					786:790	the methacrylate functional group	758:790	the methacrylate functional group	758:790	The reaction conditions introducing the methacrylate functional group are adjusted to vary the degree of functionality.
33205506	4	17	theme	meth	638:641	arg1	acrylates					643:651	water-soluble and water-insoluble (meth)acrylates	603:651	acrylates	643:651	This modification worked with a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides, grafting up to 45 wt% polymer on to the CNFs.
33205506	2	18	theme	modification	400:411	arg1	scheme					413:418	an entirely water-based, polymer modification scheme	367:418	scheme	413:418	To address this limitation, an entirely water-based, polymer modification scheme is developed.
33205506	0	19	theme	Polymer	8:14	arg1	Modification					16:27	Aqueous Polymer Modification	0:27	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through	0:72	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through a Reactive Methacrylate Group.
33205506	7	20	theme	functionalization	990:1006	arg1	degree					980:985	The degree	976:985	The degree of functionalization of the polymers	976:1022	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	0	21	dep	Group	98:102	arg1	Modification					16:27	Aqueous Polymer Modification	0:27	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through	0:72	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through a Reactive Methacrylate Group.
33205506	0	22	theme	Aqueous	0:6	arg1	Modification					16:27	Aqueous Polymer Modification	0:27	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through	0:72	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through a Reactive Methacrylate Group.
33205506	4	23	theme	water-soluble	603:615	arg1	acrylates					643:651	water-soluble and water-insoluble (meth)acrylates	603:651	acrylates	643:651	This modification worked with a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides, grafting up to 45 wt% polymer on to the CNFs.
33205506	7	24	theme	atomic	1203:1208	arg1	microscopy					1216:1225	optical, scanning electron, and atomic force microscopy	1171:1225	microscopy	1216:1225	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	4	25	theme	%	696:696	arg1	polymer					698:704	45 wt% polymer	691:704	45 wt% polymer	691:704	This modification worked with a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides, grafting up to 45 wt% polymer on to the CNFs.
33205506	7	26	theme	microscopy	1216:1225	arg1	combination					1156:1166	a combination	1154:1166	a combination of optical, scanning electron, and atomic force microscopy	1154:1225	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	1	27	theme	only	294:297	arg1	groups					316:321	only surface hydroxyl groups	294:321	only surface hydroxyl groups	294:321	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	3	28	theme	functional	487:496	arg1	group					498:502	a reactive methacrylate functional group	463:502	a reactive methacrylate functional group followed by subsequent grafting-through polymerization	463:557	CNFs are functionalized with a reactive methacrylate functional group followed by subsequent grafting-through polymerization.
33205506	7	29	dep	electron	1189:1196	arg1	scanning					1180:1187	optical, scanning electron, and atomic force microscopy	1171:1225	scanning	1180:1187	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	1	30	theme	surface	299:305	arg1	groups					316:321	only surface hydroxyl groups	294:321	only surface hydroxyl groups	294:321	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	7	31	theme	IR	1065:1066	arg1	spectroscopy					1068:1079	quantitative transmission IR spectroscopy	1039:1079	quantitative transmission IR spectroscopy	1039:1079	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	6	32	theme	methacrylate	912:923	arg1	necessary					934:942	necessary	934:942	necessary	934:942	Soxhlet extraction of modified samples demonstrates that the reactive methacrylate group is necessary to facilitate polymer grafting.
33205506	6	32	theme	methacrylate	912:923	arg1	group					925:929	the reactive methacrylate group	899:929	the reactive methacrylate group	899:929	Soxhlet extraction of modified samples demonstrates that the reactive methacrylate group is necessary to facilitate polymer grafting.
33205506	3	33	theme	grafting-through	527:542	arg1	polymerization					544:557	subsequent grafting-through polymerization	516:557	subsequent grafting-through polymerization	516:557	CNFs are functionalized with a reactive methacrylate functional group followed by subsequent grafting-through polymerization.
33205506	7	34	theme	force	1210:1214	arg1	microscopy					1216:1225	optical, scanning electron, and atomic force microscopy	1171:1225	microscopy	1216:1225	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	4	35	theme	acrylamides	663:673	arg1	acrylates					643:651	water-soluble and water-insoluble (meth)acrylates	603:651	acrylates	643:651	This modification worked with a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides, grafting up to 45 wt% polymer on to the CNFs.
33205506	4	35	theme	acrylamides	663:673	arg1	acrylamides					663:673	(meth)acrylamides	657:673	(meth)acrylamides	657:673	This modification worked with a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides, grafting up to 45 wt% polymer on to the CNFs.
33205506	4	35	theme	acrylamides	663:673	arg1	variety					592:598	a variety	590:598	a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides	590:673	This modification worked with a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides, grafting up to 45 wt% polymer on to the CNFs.
33205506	0	36	theme	Nanofibrils	42:52	arg1	Modification					16:27	Aqueous Polymer Modification	0:27	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through	0:72	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through a Reactive Methacrylate Group.
33205506	1	37	theme	hydroxyl	307:314	arg1	groups					316:321	only surface hydroxyl groups	294:321	only surface hydroxyl groups	294:321	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	5	38	theme	reaction	726:733	arg1	conditions					735:744	The reaction conditions	722:744	The reaction conditions introducing the methacrylate functional group	722:790	The reaction conditions introducing the methacrylate functional group are adjusted to vary the degree of functionality.
33205506	3	39	theme	reactive	465:472	arg1	group					498:502	a reactive methacrylate functional group	463:502	a reactive methacrylate functional group followed by subsequent grafting-through polymerization	463:557	CNFs are functionalized with a reactive methacrylate functional group followed by subsequent grafting-through polymerization.
33205506	1	40	theme	polymer	211:217	arg1	groups					230:235	polymer functional groups	211:235	polymer functional groups in an entirely water-based system	211:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	0	41	theme	Cellulose	32:40	arg1	Nanofibrils					42:52	Cellulose Nanofibrils	32:52	Cellulose Nanofibrils	32:52	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through a Reactive Methacrylate Group.
33205506	0	42	mod	Modification	16:27	arg1	Nanofibrils					42:52	Cellulose Nanofibrils	32:52	Cellulose Nanofibrils	32:52	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through a Reactive Methacrylate Group.
33205506	0	42	mod	Modification	16:27	arg3	Polymer					8:14	Aqueous Polymer Modification	0:27	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through	0:72	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through a Reactive Methacrylate Group.
33205506	1	43	from	system	264:269	arg1	groups					230:235	polymer functional groups	211:235	polymer functional groups in an entirely water-based system	211:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	1	43	from	system	264:269	arg1	variety					200:206	a variety	198:206	a variety of polymer functional groups in an entirely water-based system	198:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	1	44	theme	functional	219:228	arg1	groups					230:235	polymer functional groups	211:235	polymer functional groups in an entirely water-based system	211:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	8	45	theme	High	1228:1231	arg1	levels					1233:1238	High levels	1228:1238	High levels of polymer modification	1228:1262	High levels of polymer modification do not significantly affect the micrometer-scale fibril morphology.
33205506	3	46	theme	subsequent	516:525	arg1	polymerization					544:557	subsequent grafting-through polymerization	516:557	subsequent grafting-through polymerization	516:557	CNFs are functionalized with a reactive methacrylate functional group followed by subsequent grafting-through polymerization.
33205506	7	47	theme	nanofibrils	1127:1137	arg1	morphology					1089:1098	the morphology	1085:1098	the morphology of the resulting cellulose nanofibrils	1085:1137	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	7	48	theme	resulting	1107:1115	arg1	nanofibrils					1127:1137	the resulting cellulose nanofibrils	1103:1137	the resulting cellulose nanofibrils	1103:1137	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	1	49	from	variety	200:206	arg1	system					264:269	an entirely water-based system	240:269	an entirely water-based system	240:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	1	50	theme	cellulose	130:138	arg1	nanofibrils					140:150	cellulose nanofibrils	130:150	cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system	130:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	1	50	theme	cellulose	130:138	arg1	CNFs					153:156	CNFs	153:156	CNFs	153:156	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	1	51	from	groups	230:235	arg1	system					264:269	an entirely water-based system	240:269	an entirely water-based system	240:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	6	52	theme	samples	873:879	arg1	extraction					850:859	Soxhlet extraction	842:859	Soxhlet extraction of modified samples	842:879	Soxhlet extraction of modified samples demonstrates that the reactive methacrylate group is necessary to facilitate polymer grafting.
33205506	1	53	theme	nanofibrils	140:150	arg1	surface					119:125	the surface	115:125	the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system	115:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	1	54	theme	groups	230:235	arg1	groups					230:235	polymer functional groups	211:235	polymer functional groups in an entirely water-based system	211:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	1	54	theme	groups	230:235	arg1	variety					200:206	a variety	198:206	a variety of polymer functional groups in an entirely water-based system	198:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	1	55	with	refinement	182:191	arg1	groups					230:235	polymer functional groups	211:235	polymer functional groups in an entirely water-based system	211:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	1	55	with	refinement	182:191	arg1	variety					200:206	a variety	198:206	a variety of polymer functional groups in an entirely water-based system	198:269	Modifying the surface of cellulose nanofibrils (CNFs) produced by mechanical refinement with a variety of polymer functional groups in an entirely water-based system is challenging because only surface hydroxyl groups are accessible.
33205506	6	56	theme	modified	864:871	arg1	samples					873:879	modified samples	864:879	modified samples	864:879	Soxhlet extraction of modified samples demonstrates that the reactive methacrylate group is necessary to facilitate polymer grafting.
33205506	7	57	theme	quantitative	1039:1050	arg1	spectroscopy					1068:1079	quantitative transmission IR spectroscopy	1039:1079	quantitative transmission IR spectroscopy	1039:1079	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	0	58	theme	Reactive	76:83	arg1	Group					98:102	a Reactive Methacrylate Group	74:102	a Reactive Methacrylate Group	74:102	Aqueous Polymer Modification of Cellulose Nanofibrils by Grafting-Through a Reactive Methacrylate Group.
33205506	3	59	theme	methacrylate	474:485	arg1	group					498:502	a reactive methacrylate functional group	463:502	a reactive methacrylate functional group followed by subsequent grafting-through polymerization	463:557	CNFs are functionalized with a reactive methacrylate functional group followed by subsequent grafting-through polymerization.
33205506	2	60	dep	scheme	413:418	arg1	polymer					392:398	an entirely water-based, polymer modification scheme	367:418	polymer	392:398	To address this limitation, an entirely water-based, polymer modification scheme is developed.
33205506	7	61	theme	transmission	1052:1063	arg1	spectroscopy					1068:1079	quantitative transmission IR spectroscopy	1039:1079	quantitative transmission IR spectroscopy	1039:1079	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	2	62	theme	water-based	379:389	arg1	scheme					413:418	an entirely water-based, polymer modification scheme	367:418	scheme	413:418	To address this limitation, an entirely water-based, polymer modification scheme is developed.
33205506	8	63	theme	micrometer-scale	1296:1311	arg1	morphology					1320:1329	the micrometer-scale fibril morphology	1292:1329	the micrometer-scale fibril morphology	1292:1329	High levels of polymer modification do not significantly affect the micrometer-scale fibril morphology.
33205506	7	64	theme	cellulose	1117:1125	arg1	nanofibrils					1127:1137	the resulting cellulose nanofibrils	1103:1137	the resulting cellulose nanofibrils	1103:1137	The degree of functionalization of the polymers is studied via quantitative transmission IR spectroscopy and the morphology of the resulting cellulose nanofibrils is studied via a combination of optical, scanning electron, and atomic force microscopy.
33205506	5	65	theme	functionality	827:839	arg1	degree					817:822	the degree	813:822	the degree of functionality	813:839	The reaction conditions introducing the methacrylate functional group are adjusted to vary the degree of functionality.
33205506	4	66	theme	meth	658:661	arg1	acrylamides					663:673	(meth)acrylamides	657:673	(meth)acrylamides	657:673	This modification worked with a variety of water-soluble and water-insoluble (meth)acrylates and (meth)acrylamides, grafting up to 45 wt% polymer on to the CNFs.
34600679	0	0	theme	fatty	111:115	arg1	acid					117:120	short-chain fatty acid	99:120	short-chain fatty acid	99:120	Enzymatically synthesised fructooligosaccharides from sugarcane syrup modulate the composition and short-chain fatty acid production of the human intestinal microbiota.
34600679	3	1	theme	Bacteroides/Prevotella	819:840	arg1	counts					842:847	Bacteroides/Prevotella counts	819:847	Bacteroides/Prevotella counts	819:847	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	2	2	theme	SS	408:409	arg1	effect					378:383	the prebiotic effect	364:383	the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production	364:527	This study evaluated the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production.
34600679	0	3	theme	short-chain	99:109	arg1	acid					117:120	short-chain fatty acid	99:120	short-chain fatty acid	99:120	Enzymatically synthesised fructooligosaccharides from sugarcane syrup modulate the composition and short-chain fatty acid production of the human intestinal microbiota.
34600679	5	4	theme	Bacteroides/Prevotella	1030:1051	arg1	growth					1053:1058	The steady Bacteroides/Prevotella growth	1019:1058	The steady Bacteroides/Prevotella growth	1019:1058	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	2	5	theme	unpurified/purified	388:406	arg1	SS					408:409	unpurified/purified SS	388:409	unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production	388:527	This study evaluated the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production.
34600679	1	6	theme	58.93	292:296	arg1	%					297:297	%	297:297	%	297:297	Fructooligosaccharides can be produced by direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose.
34600679	6	7	theme	representative	1286:1299	arg1	microbiota					1305:1314	representative gut microbiota	1286:1314	representative gut microbiota	1286:1314	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	3	8	theme	Bifidobacterium	766:780	arg1	counts					782:787	the Bifidobacterium counts	762:787	the Bifidobacterium counts	762:787	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	1	9	theme	%	297:297	arg1	sucrose					299:305	58.93% sucrose	292:305	58.93% sucrose yielding 21.28 g FOS/100 g sucrose	292:340	Fructooligosaccharides can be produced by direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose.
34600679	0	10	theme	acid	117:120	arg1	production					122:131	the composition and short-chain fatty acid production	79:131	the composition and short-chain fatty acid production of the human intestinal microbiota	79:166	Enzymatically synthesised fructooligosaccharides from sugarcane syrup modulate the composition and short-chain fatty acid production of the human intestinal microbiota.
34600679	1	11	from	syrup	267:271	arg1	conversion					228:237	direct enzymatic conversion	211:237	direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose	211:340	Fructooligosaccharides can be produced by direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose.
34600679	3	12	theme	1-kestose	598:606	arg1	mixture					587:593	a mixture	585:593	a mixture of 1-kestose, nystose and 1F-fructosylnystose	585:639	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	3	12	theme	1-kestose	598:606	arg1	substrates					562:571	The unpurified and purified FOS substrates	530:571	The unpurified and purified FOS substrates	530:571	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	6	13	from	metabolites	1403:1413	arg1	conditions					1432:1441	pH-controlled conditions	1418:1441	pH-controlled conditions	1418:1441	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	6	14	theme	gut	1301:1303	arg1	microbiota					1305:1314	representative gut microbiota	1286:1314	representative gut microbiota	1286:1314	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	2	15	theme	intestinal	458:467	arg1	composition					479:489	the human intestinal microbial composition	448:489	the human intestinal microbial composition	448:489	This study evaluated the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production.
34600679	6	16	theme	synthesised	1348:1358	arg1	FOS					1360:1362	the enzymatically synthesised FOS	1330:1362	the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks	1330:1524	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	5	17	theme	Bifidobacterium	1074:1088	arg1	population					1090:1099	increased Bifidobacterium population	1064:1099	increased Bifidobacterium population	1064:1099	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	6	18	theme	fatty	1388:1392	arg1	acids					1394:1398	short-chain fatty acids	1376:1398	short-chain fatty acids	1376:1398	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	2	19	contain	containing	411:420	arg2	FOS					422:424	FOS	422:424	FOS for the modulation of the human intestinal microbial composition	422:489	This study evaluated the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production.
34600679	2	19	contain	containing	411:420	arg1	SS					408:409	unpurified/purified SS	388:409	unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production	388:527	This study evaluated the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production.
34600679	2	19	contain	containing	411:420	arg2	production					518:527	short-chain fatty acid production	495:527	short-chain fatty acid production	495:527	This study evaluated the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production.
34600679	4	20	theme	5 h	964:966	arg1	fermentation					968:979	5 h fermentation	964:979	5 h fermentation	964:979	Meanwhile, Lactobacillus/Enterococcus exhibited a slight increase after 5 h fermentation before reaching a plateau afterwards.
34600679	5	21	theme	short-chain	1143:1153	arg1	acetate					1167:1173	acetate	1167:1173	acetate (58 ± 2.70 mM)	1167:1188	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	5	21	theme	short-chain	1143:1153	arg1	acids					1161:1165	short-chain fatty acids	1143:1165	short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM)	1143:1247	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	5	21	theme	short-chain	1143:1153	arg1	butyrate					1223:1230	butyrate	1223:1230	butyrate (7.15 ± 2.28 mM)	1223:1247	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	5	21	theme	short-chain	1143:1153	arg1	propionate					1191:1200	propionate	1191:1200	propionate (9.19 ± 5.94 mM)	1191:1217	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	1	22	theme	direct	211:216	arg1	conversion					228:237	direct enzymatic conversion	211:237	direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose	211:340	Fructooligosaccharides can be produced by direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose.
34600679	0	23	theme	synthesised	14:24	arg1	fructooligosaccharides					26:47	Enzymatically synthesised fructooligosaccharides	0:47	Enzymatically synthesised fructooligosaccharides from sugarcane syrup	0:68	Enzymatically synthesised fructooligosaccharides from sugarcane syrup modulate the composition and short-chain fatty acid production of the human intestinal microbiota.
34600679	1	24	theme	enzymatic	218:226	arg1	conversion					228:237	direct enzymatic conversion	211:237	direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose	211:340	Fructooligosaccharides can be produced by direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose.
34600679	2	25	theme	short-chain	495:505	arg1	acid					513:516	short-chain fatty acid	495:516	short-chain fatty acid production	495:527	This study evaluated the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production.
34600679	6	26	theme	short-chain	1376:1386	arg1	acids					1394:1398	short-chain fatty acids	1376:1398	short-chain fatty acids	1376:1398	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	3	27	theme	1F-fructosylnystose	621:639	arg1	mixture					587:593	a mixture	585:593	a mixture of 1-kestose, nystose and 1F-fructosylnystose	585:639	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	3	27	theme	1F-fructosylnystose	621:639	arg1	substrates					562:571	The unpurified and purified FOS substrates	530:571	The unpurified and purified FOS substrates	530:571	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	6	28	theme	health	1512:1517	arg1	drinks					1519:1524	health drinks	1512:1524	health drinks	1512:1524	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	3	29	theme	fermentation	714:725	arg1	system					727:732	a pH-controlled batch fermentation system	692:732	a pH-controlled batch fermentation system	692:732	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	1	30	theme	21.28 g	316:322	arg1	sucrose					334:340	21.28 g FOS/100 g sucrose	316:340	21.28 g FOS/100 g sucrose	316:340	Fructooligosaccharides can be produced by direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose.
34600679	0	31	theme	intestinal	146:155	arg1	microbiota					157:166	the human intestinal microbiota	136:166	the human intestinal microbiota	136:166	Enzymatically synthesised fructooligosaccharides from sugarcane syrup modulate the composition and short-chain fatty acid production of the human intestinal microbiota.
34600679	6	32	theme	pH-controlled	1418:1430	arg1	conditions					1432:1441	pH-controlled conditions	1418:1441	pH-controlled conditions	1418:1441	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	2	33	theme	microbial	469:477	arg1	composition					479:489	the human intestinal microbial composition	448:489	the human intestinal microbial composition	448:489	This study evaluated the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production.
34600679	2	34	theme	composition	479:489	arg1	modulation					434:443	the modulation	430:443	the modulation of the human intestinal microbial composition	430:489	This study evaluated the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production.
34600679	1	35	theme	FOS/100 g	324:332	arg1	sucrose					334:340	21.28 g FOS/100 g sucrose	316:340	21.28 g FOS/100 g sucrose	316:340	Fructooligosaccharides can be produced by direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose.
34600679	0	36	theme	human	140:144	arg1	microbiota					157:166	the human intestinal microbiota	136:166	the human intestinal microbiota	136:166	Enzymatically synthesised fructooligosaccharides from sugarcane syrup modulate the composition and short-chain fatty acid production of the human intestinal microbiota.
34600679	3	37	theme	batch	708:712	arg1	fermentation					714:725	a pH-controlled batch fermentation	692:725	a pH-controlled batch fermentation system	692:732	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	3	38	theme	nystose	609:615	arg1	mixture					587:593	a mixture	585:593	a mixture of 1-kestose, nystose and 1F-fructosylnystose	585:639	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	3	38	theme	nystose	609:615	arg1	substrates					562:571	The unpurified and purified FOS substrates	530:571	The unpurified and purified FOS substrates	530:571	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	1	39	theme	sucrose-rich	244:255	arg1	SS					274:275	SS	274:275	SS	274:275	Fructooligosaccharides can be produced by direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose.
34600679	1	39	theme	sucrose-rich	244:255	arg1	syrup					267:271	sucrose-rich sugarcane syrup	244:271	sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose	244:340	Fructooligosaccharides can be produced by direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose.
34600679	5	40	theme	increased	1064:1072	arg1	population					1090:1099	increased Bifidobacterium population	1064:1099	increased Bifidobacterium population	1064:1099	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	2	41	theme	human	452:456	arg1	composition					479:489	the human intestinal microbial composition	448:489	the human intestinal microbial composition	448:489	This study evaluated the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production.
34600679	4	42	theme	slight	942:947	arg1	increase					949:956	a slight increase	940:956	a slight increase after 5 h fermentation	940:979	Meanwhile, Lactobacillus/Enterococcus exhibited a slight increase after 5 h fermentation before reaching a plateau afterwards.
34600679	1	43	theme	sugarcane	257:265	arg1	SS					274:275	SS	274:275	SS	274:275	Fructooligosaccharides can be produced by direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose.
34600679	1	43	theme	sugarcane	257:265	arg1	syrup					267:271	sucrose-rich sugarcane syrup	244:271	sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose	244:340	Fructooligosaccharides can be produced by direct enzymatic conversion from sucrose-rich sugarcane syrup (SS) consisting of 58.93% sucrose yielding 21.28 g FOS/100 g sucrose.
34600679	0	44	theme	sugarcane	54:62	arg1	syrup					64:68	sugarcane syrup	54:68	sugarcane syrup	54:68	Enzymatically synthesised fructooligosaccharides from sugarcane syrup modulate the composition and short-chain fatty acid production of the human intestinal microbiota.
34600679	0	45	theme	microbiota	157:166	arg1	production					122:131	the composition and short-chain fatty acid production	79:131	the composition and short-chain fatty acid production of the human intestinal microbiota	79:166	Enzymatically synthesised fructooligosaccharides from sugarcane syrup modulate the composition and short-chain fatty acid production of the human intestinal microbiota.
34600679	5	46	dep	acids	1161:1165	arg1	acetate					1167:1173	acetate	1167:1173	acetate (58 ± 2.70 mM)	1167:1188	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	5	46	dep	acids	1161:1165	arg1	9.19 ± 5.94 mM					1203:1216	9.19 ± 5.94 mM	1203:1216	9.19 ± 5.94 mM	1203:1216	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	5	46	dep	acids	1161:1165	arg1	58 ± 2.70 mM					1176:1187	58 ± 2.70 mM	1176:1187	58 ± 2.70 mM	1176:1187	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	5	46	dep	acids	1161:1165	arg1	butyrate					1223:1230	butyrate	1223:1230	butyrate (7.15 ± 2.28 mM)	1223:1247	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	5	46	dep	acids	1161:1165	arg1	propionate					1191:1200	propionate	1191:1200	propionate (9.19 ± 5.94 mM)	1191:1217	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	5	46	dep	acids	1161:1165	arg1	7.15 ± 2.28 mM					1233:1246	7.15 ± 2.28 mM	1233:1246	7.15 ± 2.28 mM	1233:1246	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	5	46	dep	acids	1161:1165	arg1	acids					1161:1165	short-chain fatty acids	1143:1165	short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM)	1143:1247	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	3	47	theme	pH-controlled	694:706	arg1	fermentation					714:725	a pH-controlled batch fermentation	692:725	a pH-controlled batch fermentation system	692:732	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	0	48	from	syrup	64:68	arg1	fructooligosaccharides					26:47	Enzymatically synthesised fructooligosaccharides	0:47	Enzymatically synthesised fructooligosaccharides from sugarcane syrup	0:68	Enzymatically synthesised fructooligosaccharides from sugarcane syrup modulate the composition and short-chain fatty acid production of the human intestinal microbiota.
34600679	3	49	theme	purified	549:556	arg1	mixture					587:593	a mixture	585:593	a mixture of 1-kestose, nystose and 1F-fructosylnystose	585:639	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	3	49	theme	purified	549:556	arg1	substrates					562:571	The unpurified and purified FOS substrates	530:571	The unpurified and purified FOS substrates	530:571	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	2	50	theme	acid	513:516	arg1	production					518:527	short-chain fatty acid production	495:527	short-chain fatty acid production	495:527	This study evaluated the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production.
34600679	3	51	theme	FOS	558:560	arg1	mixture					587:593	a mixture	585:593	a mixture of 1-kestose, nystose and 1F-fructosylnystose	585:639	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	3	51	theme	FOS	558:560	arg1	substrates					562:571	The unpurified and purified FOS substrates	530:571	The unpurified and purified FOS substrates	530:571	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	5	52	from	increase	1113:1120	arg1	production					1129:1138	the production	1125:1138	the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM)	1125:1247	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	3	53	theme	24 h	873:876	arg1	fermentation					878:889	24 h fermentation	873:889	24 h fermentation	873:889	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	6	54	theme	prebiotic	1477:1485	arg1	ingredient					1487:1496	a potential prebiotic ingredient	1465:1496	a potential prebiotic ingredient for foods and health drinks	1465:1524	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	6	54	theme	prebiotic	1477:1485	arg1	metabolites					1403:1413	metabolites	1403:1413	metabolites in pH-controlled conditions	1403:1441	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	5	55	theme	fatty	1155:1159	arg1	acetate					1167:1173	acetate	1167:1173	acetate (58 ± 2.70 mM)	1167:1188	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	5	55	theme	fatty	1155:1159	arg1	acids					1161:1165	short-chain fatty acids	1143:1165	short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM)	1143:1247	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	5	55	theme	fatty	1155:1159	arg1	butyrate					1223:1230	butyrate	1223:1230	butyrate (7.15 ± 2.28 mM)	1223:1247	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	5	55	theme	fatty	1155:1159	arg1	propionate					1191:1200	propionate	1191:1200	propionate (9.19 ± 5.94 mM)	1191:1217	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	2	56	theme	prebiotic	368:376	arg1	effect					378:383	the prebiotic effect	364:383	the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production	364:527	This study evaluated the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production.
34600679	6	57	from	SS	1458:1459	arg1	ingredient					1487:1496	a potential prebiotic ingredient	1465:1496	a potential prebiotic ingredient for foods and health drinks	1465:1524	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	6	57	from	SS	1458:1459	arg1	metabolites					1403:1413	metabolites	1403:1413	metabolites in pH-controlled conditions	1403:1441	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	6	57	from	SS	1458:1459	arg1	FOS					1449:1451	FOS	1449:1451	thus FOS	1444:1451	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	6	58	theme	potential	1467:1475	arg1	ingredient					1487:1496	a potential prebiotic ingredient	1465:1496	a potential prebiotic ingredient for foods and health drinks	1465:1524	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	6	58	theme	potential	1467:1475	arg1	metabolites					1403:1413	metabolites	1403:1413	metabolites in pH-controlled conditions	1403:1441	These results provide evidence that representative gut microbiota could utilise the enzymatically synthesised FOS to generate short-chain fatty acids as metabolites in pH-controlled conditions, thus FOS from SS are a potential prebiotic ingredient for foods and health drinks.
34600679	5	59	theme	acids	1161:1165	arg1	production					1129:1138	the production	1125:1138	the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM)	1125:1247	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	5	60	theme	steady	1023:1028	arg1	growth					1053:1058	The steady Bacteroides/Prevotella growth	1019:1058	The steady Bacteroides/Prevotella growth	1019:1058	The steady Bacteroides/Prevotella growth and increased Bifidobacterium population promoted an increase in the production of short-chain fatty acids acetate (58 ± 2.70 mM), propionate (9.19 ± 5.94 mM) and butyrate (7.15 ± 2.28 mM).
34600679	3	61	theme	unpurified	534:543	arg1	mixture					587:593	a mixture	585:593	a mixture of 1-kestose, nystose and 1F-fructosylnystose	585:639	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	3	61	theme	unpurified	534:543	arg1	substrates					562:571	The unpurified and purified FOS substrates	530:571	The unpurified and purified FOS substrates	530:571	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	3	62	theme	human	665:669	arg1	culture					678:684	human faecal culture	665:684	human faecal culture using a pH-controlled batch fermentation system	665:732	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	0	63	theme	composition	83:93	arg1	production					122:131	the composition and short-chain fatty acid production	79:131	the composition and short-chain fatty acid production of the human intestinal microbiota	79:166	Enzymatically synthesised fructooligosaccharides from sugarcane syrup modulate the composition and short-chain fatty acid production of the human intestinal microbiota.
34600679	3	64	theme	faecal	671:676	arg1	culture					678:684	human faecal culture	665:684	human faecal culture using a pH-controlled batch fermentation system	665:732	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
34600679	2	65	theme	fatty	507:511	arg1	acid					513:516	short-chain fatty acid	495:516	short-chain fatty acid production	495:527	This study evaluated the prebiotic effect of unpurified/purified SS containing FOS for the modulation of the human intestinal microbial composition and short-chain fatty acid production.
34600679	3	66	theme	5 h	795:797	arg1	fermentation					799:810	5 h fermentation	795:810	5 h fermentation	795:810	The unpurified and purified FOS substrates, which were a mixture of 1-kestose, nystose and 1F-fructosylnystose, were supplemented into human faecal culture using a pH-controlled batch fermentation system and significantly increased the Bifidobacterium counts after 5 h fermentation, while Bacteroides/Prevotella counts were highest throughout 24 h fermentation.
33242553	2	0	theme	entrapment	499:508	arg1	efficiency					510:519	The highest 93.33% entrapment efficiency	480:519	The highest 93.33% entrapment efficiency of IBU	480:526	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	1	1	theme	1.97 ± 0.09-1.22 ± 0.13 mm	345:370	arg1	range					336:340	the size range	327:340	the size range of 1.97 ± 0.09-1.22 ± 0.13 mm	327:370	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	2	2	theme	entrapment	598:607	arg1	efficiency					609:618	entrapment efficiency	598:618	entrapment efficiency of beads	598:627	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	5	3	dep	%	1233:1233	arg1	MC					1241:1242	MC	1241:1242	33.3% (w/w) MC	1229:1242	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	1	4	theme	crosslinked	187:197	arg1	networks					304:311	semi-interpenetrating polymer networks	274:311	semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm	274:370	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	1	4	theme	crosslinked	187:197	arg1	beads					199:203	ionically crosslinked beads	177:203	ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC)	177:255	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	1	5	with	crosslinking	375:386	arg1	FeCl3					393:397	FeCl3	393:397	FeCl3	393:397	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	4	6	theme	NaAlg	1110:1114	arg1	NaAlg					1110:1114	NaAlg	1110:1114	NaAlg	1110:1114	It was observed that IBU-loaded beads displayed better release performance with an increase amount of NaAlg in the structure.
33242553	4	6	theme	NaAlg	1110:1114	arg1	amount					1100:1105	an increase amount	1088:1105	an increase amount of NaAlg in the structure	1088:1131	It was observed that IBU-loaded beads displayed better release performance with an increase amount of NaAlg in the structure.
33242553	6	7	theme	Case	1518:1521	arg1	mechanism					1536:1544	the Anomalous and Case II transport mechanism	1500:1544	mechanism	1536:1544	The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
33242553	4	8	theme	IBU-loaded	1029:1038	arg1	beads					1040:1044	IBU-loaded beads	1029:1044	IBU-loaded beads	1029:1044	It was observed that IBU-loaded beads displayed better release performance with an increase amount of NaAlg in the structure.
33242553	5	9	theme	90 min	1326:1331	arg1	time					1318:1321	crosslinking time	1305:1321	crosslinking time of 90 min	1305:1331	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	9	theme	90 min	1326:1331	arg1	%					1214:1214	66.7%	1210:1214	66.7% (w/w) NaAlg	1210:1226	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	9	theme	90 min	1326:1331	arg1	concentration					1277:1289	FeCl3 concentration	1271:1289	FeCl3 concentration of 0.1 M	1271:1298	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	9	theme	90 min	1326:1331	arg1	%					1233:1233	33.3%	1229:1233	33.3% (w/w) MC	1229:1242	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	9	theme	90 min	1326:1331	arg1	0.1 M					1294:1298	0.1 M	1294:1298	0.1 M	1294:1298	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	9	theme	90 min	1326:1331	arg1	90 min					1326:1331	90 min	1326:1331	90 min	1326:1331	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	9	theme	90 min	1326:1331	arg1	ratio					1257:1261	IBU/polymer ratio	1245:1261	IBU/polymer ratio of 1/4	1245:1268	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	9	theme	90 min	1326:1331	arg1	w/w					1236:1238	w/w	1236:1238	w/w	1236:1238	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	9	theme	90 min	1326:1331	arg1	w/w					1217:1219	w/w	1217:1219	w/w	1217:1219	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	9	theme	90 min	1326:1331	arg1	1/4					1266:1268	1/4	1266:1268	1/4	1266:1268	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	3	10	theme	scanning	972:979	arg1	microscopy					990:999	scanning electron microscopy	972:999	scanning electron microscopy (SEM)	972:1005	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	3	10	theme	scanning	972:979	arg1	SEM					1002:1004	SEM	1002:1004	SEM	1002:1004	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	6	11	theme	release	1455:1461	arg1	mechanism					1463:1471	the release mechanism	1451:1471	the release mechanism of IBU from beads	1451:1489	The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
33242553	1	12	theme	nonsteroidal	443:454	arg1	drug					474:477	a nonsteroidal anti-inflammatory drug	441:477	a nonsteroidal anti-inflammatory drug	441:477	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	1	12	theme	nonsteroidal	443:454	arg1	ibuprofen					415:423	ibuprofen	415:423	ibuprofen (IBU)	415:429	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	6	13	theme	in	1338:1339	arg1	rate					1355:1358	The in vitro release rate	1334:1358	The in vitro release rate	1334:1358	The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
33242553	1	14	theme	semi-interpenetrating	274:294	arg1	semi-IPN					314:321	semi-IPN	314:321	semi-IPN	314:321	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	1	14	theme	semi-interpenetrating	274:294	arg1	networks					304:311	semi-interpenetrating polymer networks	274:311	semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm	274:370	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	1	14	theme	semi-interpenetrating	274:294	arg1	beads					199:203	ionically crosslinked beads	177:203	ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC)	177:255	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	0	15	theme	controlled	129:138	arg1	release					140:146	controlled release	129:146	controlled release of ibuprofen	129:159	Development and optimization of Fe3+-crosslinked sodium alginate-methylcellulose semi-interpenetrating polymer network beads for controlled release of ibuprofen.
33242553	6	16	theme	diffusion	1408:1416	arg1	exponent					1418:1425	the diffusion exponent	1404:1425	the diffusion exponent n	1404:1427	The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
33242553	1	17	theme	anti-inflammatory	456:472	arg1	drug					474:477	a nonsteroidal anti-inflammatory drug	441:477	a nonsteroidal anti-inflammatory drug	441:477	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	1	17	theme	anti-inflammatory	456:472	arg1	ibuprofen					415:423	ibuprofen	415:423	ibuprofen (IBU)	415:429	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	4	18	theme	increase	1091:1098	arg1	NaAlg					1110:1114	NaAlg	1110:1114	NaAlg	1110:1114	It was observed that IBU-loaded beads displayed better release performance with an increase amount of NaAlg in the structure.
33242553	4	18	theme	increase	1091:1098	arg1	amount					1100:1105	an increase amount	1088:1105	an increase amount of NaAlg in the structure	1088:1131	It was observed that IBU-loaded beads displayed better release performance with an increase amount of NaAlg in the structure.
33242553	3	19	theme	differential	901:912	arg1	DSC					936:938	DSC	936:938	DSC	936:938	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	3	19	theme	differential	901:912	arg1	calorimetry					923:933	differential scanning calorimetry	901:933	differential scanning calorimetry (DSC)	901:939	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	1	20	theme	polymer	296:302	arg1	semi-IPN					314:321	semi-IPN	314:321	semi-IPN	314:321	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	1	20	theme	polymer	296:302	arg1	networks					304:311	semi-interpenetrating polymer networks	274:311	semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm	274:370	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	1	20	theme	polymer	296:302	arg1	beads					199:203	ionically crosslinked beads	177:203	ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC)	177:255	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	0	21	theme	ibuprofen	151:159	arg1	release					140:146	controlled release	129:146	controlled release of ibuprofen	129:159	Development and optimization of Fe3+-crosslinked sodium alginate-methylcellulose semi-interpenetrating polymer network beads for controlled release of ibuprofen.
33242553	4	22	theme	release	1063:1069	arg1	performance					1071:1081	better release performance	1056:1081	better release performance	1056:1081	It was observed that IBU-loaded beads displayed better release performance with an increase amount of NaAlg in the structure.
33242553	3	23	theme	electron	981:988	arg1	microscopy					990:999	scanning electron microscopy	972:999	scanning electron microscopy (SEM)	972:1005	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	3	23	theme	electron	981:988	arg1	SEM					1002:1004	SEM	1002:1004	SEM	1002:1004	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	3	24	theme	scanning	914:921	arg1	DSC					936:938	DSC	936:938	DSC	936:938	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	3	24	theme	scanning	914:921	arg1	calorimetry					923:933	differential scanning calorimetry	901:933	differential scanning calorimetry (DSC)	901:939	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	2	25	dep	%	497:497	arg1	93.33					492:496	93.33	492:496	93.33	492:496	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	2	26	theme	IBU	524:526	arg1	efficiency					510:519	The highest 93.33% entrapment efficiency	480:519	The highest 93.33% entrapment efficiency of IBU	480:526	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	2	27	theme	beads	623:627	arg1	size					588:591	mean particle size	574:591	mean particle size	574:591	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	2	27	theme	beads	623:627	arg1	efficiency					609:618	entrapment efficiency	598:618	entrapment efficiency of beads	598:627	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	2	27	theme	beads	623:627	arg1	behaviors					563:571	the drug release behaviors	546:571	the drug release behaviors	546:571	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	5	28	dep	%	1214:1214	arg1	NaAlg					1222:1226	NaAlg	1222:1226	66.7% (w/w) NaAlg	1210:1226	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	29	theme	IBU/polymer	1245:1255	arg1	ratio					1257:1261	IBU/polymer ratio	1245:1261	IBU/polymer ratio of 1/4	1245:1268	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	1	30	theme	sodium	208:213	arg1	alginate					215:222	sodium alginate	208:222	sodium alginate (NaAlg)	208:230	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	1	30	theme	sodium	208:213	arg1	NaAlg					225:229	NaAlg	225:229	NaAlg	225:229	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	1	31	from	networks	304:311	arg1	range					336:340	the size range	327:340	the size range of 1.97 ± 0.09-1.22 ± 0.13 mm	327:370	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	2	32	theme	composition	671:681	arg1	terms					650:654	terms	650:654	terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent	650:789	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	2	33	theme	mean	574:577	arg1	size					588:591	mean particle size	574:591	mean particle size	574:591	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	1	34	theme	alginate	215:222	arg1	networks					304:311	semi-interpenetrating polymer networks	274:311	semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm	274:370	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	1	34	theme	alginate	215:222	arg1	beads					199:203	ionically crosslinked beads	177:203	ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC)	177:255	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	3	35	dep	Fourier	853:859	arg1	transform					861:869	transform	861:869	transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM)	861:1005	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	2	36	theme	polymer	663:669	arg1	composition					671:681	polymer composition	663:681	polymer composition	663:681	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	4	37	theme	better	1056:1061	arg1	performance					1071:1081	better release performance	1056:1081	better release performance	1056:1081	It was observed that IBU-loaded beads displayed better release performance with an increase amount of NaAlg in the structure.
33242553	5	38	theme	crosslinking	1305:1316	arg1	time					1318:1321	crosslinking time	1305:1321	crosslinking time of 90 min	1305:1331	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	1	39	link	crosslinked	187:197	arg1	networks					304:311	semi-interpenetrating polymer networks	274:311	semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm	274:370	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	1	39	link	crosslinked	187:197	arg1	beads					199:203	ionically crosslinked beads	177:203	ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC)	177:255	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	0	40	link	Fe3+-crosslinked	32:47	arg1	sodium					49:54	Fe3+-crosslinked sodium	32:54	Fe3+-crosslinked sodium	32:54	Development and optimization of Fe3+-crosslinked sodium alginate-methylcellulose semi-interpenetrating polymer network beads for controlled release of ibuprofen.
33242553	6	41	dep	exponent	1418:1425	arg1	n					1427:1427	n	1427:1427	the diffusion exponent n	1404:1427	The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
33242553	5	42	theme	optimum	1147:1153	arg1	%					1187:1187	93.9%	1183:1187	93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min	1183:1331	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	42	theme	optimum	1147:1153	arg1	release					1159:1165	the optimum IBU release	1143:1165	the optimum IBU release	1143:1165	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	2	43	theme	drug	550:553	arg1	behaviors					563:571	the drug release behaviors	546:571	the drug release behaviors	546:571	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	3	44	dep	transform	861:869	arg1	infrared					871:878	infrared	871:878	transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM)	861:1005	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	6	45	theme	empirical	1379:1387	arg1	equations					1389:1397	five empirical equations	1374:1397	five empirical equations	1374:1397	The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
33242553	2	46	theme	concentration	751:763	arg1	terms					650:654	terms	650:654	terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent	650:789	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	0	47	theme	sodium	49:54	arg1	optimization					16:27	optimization	16:27	optimization	16:27	Development and optimization of Fe3+-crosslinked sodium alginate-methylcellulose semi-interpenetrating polymer network beads for controlled release of ibuprofen.
33242553	0	47	theme	sodium	49:54	arg1	Development					0:10	Development	0:10	Development	0:10	Development and optimization of Fe3+-crosslinked sodium alginate-methylcellulose semi-interpenetrating polymer network beads for controlled release of ibuprofen.
33242553	5	48	theme	IBU	1155:1157	arg1	%					1187:1187	93.9%	1183:1187	93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min	1183:1331	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	48	theme	IBU	1155:1157	arg1	release					1159:1165	the optimum IBU release	1143:1165	the optimum IBU release	1143:1165	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	2	49	dep	composition	671:681	arg1	the					659:661	the	659:661	the	659:661	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	0	50	theme	Fe3+-crosslinked	32:47	arg1	sodium					49:54	Fe3+-crosslinked sodium	32:54	Fe3+-crosslinked sodium	32:54	Development and optimization of Fe3+-crosslinked sodium alginate-methylcellulose semi-interpenetrating polymer network beads for controlled release of ibuprofen.
33242553	2	51	theme	ibuprofen	695:703	arg1	concentration					751:763	concentration	751:763	concentration	751:763	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	2	51	theme	ibuprofen	695:703	arg1	composition					671:681	polymer composition	663:681	polymer composition	663:681	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	2	51	theme	ibuprofen	695:703	arg1	ratio					686:690	a ratio	684:690	a ratio of ibuprofen to polymer, exposure time to crosslinker	684:744	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	1	52	theme	methylcellulose	236:250	arg1	networks					304:311	semi-interpenetrating polymer networks	274:311	semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm	274:370	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	1	52	theme	methylcellulose	236:250	arg1	beads					199:203	ionically crosslinked beads	177:203	ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC)	177:255	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	0	53	theme	semi-interpenetrating	81:101	arg1	beads					119:123	semi-interpenetrating polymer network beads	81:123	semi-interpenetrating polymer network beads	81:123	Development and optimization of Fe3+-crosslinked sodium alginate-methylcellulose semi-interpenetrating polymer network beads for controlled release of ibuprofen.
33242553	2	54	theme	particle	579:586	arg1	size					588:591	mean particle size	574:591	mean particle size	574:591	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	6	55	dep	in	1338:1339	arg1	vitro					1341:1345	vitro	1341:1345	vitro	1341:1345	The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
33242553	1	56	theme	size	331:334	arg1	range					336:340	the size range	327:340	the size range of 1.97 ± 0.09-1.22 ± 0.13 mm	327:370	In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl3 and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug.
33242553	2	57	theme	release	555:561	arg1	behaviors					563:571	the drug release behaviors	546:571	the drug release behaviors	546:571	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	2	58	theme	ratio	686:690	arg1	terms					650:654	terms	650:654	terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent	650:789	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	6	59	theme	release	1347:1353	arg1	rate					1355:1358	The in vitro release rate	1334:1358	The in vitro release rate	1334:1358	The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
33242553	6	60	theme	IBU	1476:1478	arg1	mechanism					1463:1471	the release mechanism	1451:1471	the release mechanism of IBU from beads	1451:1489	The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
33242553	3	61	theme	X-ray	942:946	arg1	Diffraction					948:958	X-ray Diffraction	942:958	X-ray Diffraction (X-RD)	942:965	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	3	61	theme	X-ray	942:946	arg1	X-RD					961:964	X-RD	961:964	X-RD	961:964	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	4	62	from	amount	1100:1105	arg1	structure					1123:1131	the structure	1119:1131	the structure	1119:1131	It was observed that IBU-loaded beads displayed better release performance with an increase amount of NaAlg in the structure.
33242553	2	63	dep	efficiency	510:519	arg1	%					497:497	%	497:497	%	497:497	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	6	64	theme	transport	1526:1534	arg1	mechanism					1536:1544	the Anomalous and Case II transport mechanism	1500:1544	mechanism	1536:1544	The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
33242553	5	65	theme	FeCl3	1271:1275	arg1	concentration					1277:1289	FeCl3 concentration	1271:1289	FeCl3 concentration of 0.1 M	1271:1298	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	2	66	theme	exposure	717:724	arg1	polymer					708:714	polymer	708:714	polymer	708:714	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	2	66	theme	exposure	717:724	arg1	time					726:729	exposure time	717:729	exposure time to crosslinker	717:744	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	6	67	from	mechanism	1463:1471	arg1	beads					1485:1489	beads	1485:1489	beads	1485:1489	The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
33242553	2	68	theme	agent	785:789	arg1	concentration					751:763	concentration	751:763	concentration	751:763	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	2	68	theme	agent	785:789	arg1	composition					671:681	polymer composition	663:681	polymer composition	663:681	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	2	68	theme	agent	785:789	arg1	ratio					686:690	a ratio	684:690	a ratio of ibuprofen to polymer, exposure time to crosslinker	684:744	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	3	69	theme	Semi-IPN	792:799	arg1	formulations					801:812	Semi-IPN formulations	792:812	Semi-IPN formulations prepared	792:821	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	0	70	theme	network	111:117	arg1	beads					119:123	semi-interpenetrating polymer network beads	81:123	semi-interpenetrating polymer network beads	81:123	Development and optimization of Fe3+-crosslinked sodium alginate-methylcellulose semi-interpenetrating polymer network beads for controlled release of ibuprofen.
33242553	6	71	from	beads	1485:1489	arg1	IBU					1476:1478	IBU	1476:1478	IBU from beads	1476:1489	The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
33242553	6	71	from	beads	1485:1489	arg1	mechanism					1463:1471	the release mechanism	1451:1471	the release mechanism of IBU from beads	1451:1489	The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
33242553	2	72	theme	crosslinking	772:783	arg1	agent					785:789	the crosslinking agent	768:789	the crosslinking agent	768:789	The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent.
33242553	0	73	theme	polymer	103:109	arg1	beads					119:123	semi-interpenetrating polymer network beads	81:123	semi-interpenetrating polymer network beads	81:123	Development and optimization of Fe3+-crosslinked sodium alginate-methylcellulose semi-interpenetrating polymer network beads for controlled release of ibuprofen.
33242553	5	74	contain	containing	1199:1208	arg2	w/w					1236:1238	w/w	1236:1238	w/w	1236:1238	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	74	contain	containing	1199:1208	arg2	w/w					1217:1219	w/w	1217:1219	w/w	1217:1219	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	74	contain	containing	1199:1208	arg2	ratio					1257:1261	IBU/polymer ratio	1245:1261	IBU/polymer ratio of 1/4	1245:1268	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	74	contain	containing	1199:1208	arg2	1/4					1266:1268	1/4	1266:1268	1/4	1266:1268	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	74	contain	containing	1199:1208	arg2	concentration					1277:1289	FeCl3 concentration	1271:1289	FeCl3 concentration of 0.1 M	1271:1298	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	74	contain	containing	1199:1208	arg2	time					1318:1321	crosslinking time	1305:1321	crosslinking time of 90 min	1305:1331	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	74	contain	containing	1199:1208	arg1	beads					1193:1197	beads	1193:1197	beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min	1193:1331	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	74	contain	containing	1199:1208	arg2	0.1 M					1294:1298	0.1 M	1294:1298	0.1 M	1294:1298	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	74	contain	containing	1199:1208	arg2	90 min					1326:1331	90 min	1326:1331	90 min	1326:1331	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	74	contain	containing	1199:1208	arg2	%					1233:1233	33.3%	1229:1233	33.3% (w/w) MC	1229:1242	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	74	contain	containing	1199:1208	arg2	%					1214:1214	66.7%	1210:1214	66.7% (w/w) NaAlg	1210:1226	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	75	theme	1/4	1266:1268	arg1	time					1318:1321	crosslinking time	1305:1321	crosslinking time of 90 min	1305:1331	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	75	theme	1/4	1266:1268	arg1	%					1214:1214	66.7%	1210:1214	66.7% (w/w) NaAlg	1210:1226	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	75	theme	1/4	1266:1268	arg1	concentration					1277:1289	FeCl3 concentration	1271:1289	FeCl3 concentration of 0.1 M	1271:1298	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	75	theme	1/4	1266:1268	arg1	%					1233:1233	33.3%	1229:1233	33.3% (w/w) MC	1229:1242	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	75	theme	1/4	1266:1268	arg1	0.1 M					1294:1298	0.1 M	1294:1298	0.1 M	1294:1298	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	75	theme	1/4	1266:1268	arg1	90 min					1326:1331	90 min	1326:1331	90 min	1326:1331	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	75	theme	1/4	1266:1268	arg1	ratio					1257:1261	IBU/polymer ratio	1245:1261	IBU/polymer ratio of 1/4	1245:1268	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	75	theme	1/4	1266:1268	arg1	w/w					1236:1238	w/w	1236:1238	w/w	1236:1238	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	75	theme	1/4	1266:1268	arg1	w/w					1217:1219	w/w	1217:1219	w/w	1217:1219	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	75	theme	1/4	1266:1268	arg1	1/4					1266:1268	1/4	1266:1268	1/4	1266:1268	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	3	76	theme	FTIR	881:884	arg1	spectroscopy					887:898	(FTIR) spectroscopy	880:898	(FTIR) spectroscopy	880:898	Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM).
33242553	5	77	theme	0.1 M	1294:1298	arg1	time					1318:1321	crosslinking time	1305:1321	crosslinking time of 90 min	1305:1331	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	77	theme	0.1 M	1294:1298	arg1	%					1214:1214	66.7%	1210:1214	66.7% (w/w) NaAlg	1210:1226	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	77	theme	0.1 M	1294:1298	arg1	concentration					1277:1289	FeCl3 concentration	1271:1289	FeCl3 concentration of 0.1 M	1271:1298	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	77	theme	0.1 M	1294:1298	arg1	%					1233:1233	33.3%	1229:1233	33.3% (w/w) MC	1229:1242	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	77	theme	0.1 M	1294:1298	arg1	0.1 M					1294:1298	0.1 M	1294:1298	0.1 M	1294:1298	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	77	theme	0.1 M	1294:1298	arg1	90 min					1326:1331	90 min	1326:1331	90 min	1326:1331	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	77	theme	0.1 M	1294:1298	arg1	ratio					1257:1261	IBU/polymer ratio	1245:1261	IBU/polymer ratio of 1/4	1245:1268	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	77	theme	0.1 M	1294:1298	arg1	w/w					1236:1238	w/w	1236:1238	w/w	1236:1238	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	77	theme	0.1 M	1294:1298	arg1	w/w					1217:1219	w/w	1217:1219	w/w	1217:1219	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
33242553	5	77	theme	0.1 M	1294:1298	arg1	1/4					1266:1268	1/4	1266:1268	1/4	1266:1268	Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl3 concentration of 0.1 M, and crosslinking time of 90 min.
34009590	5	0	theme	enzyme-producing	807:822	arg1	species					836:842	other enzyme-producing Trichoderma species	801:842	other enzyme-producing Trichoderma species	801:842	However, the genetic manipulation of other enzyme-producing Trichoderma species is frequently less efficient and, therefore, rarely managed.
34009590	4	1	theme	main	520:523	arg1	producer					525:532	The filamentous fungus Trichoderma reesei-the main producer	474:532	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has	474:607	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	4	2	theme	improvement	742:752	arg1	examples					707:714	the iconic examples	696:714	the iconic examples of the successful genetic improvement of fungi	696:761	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	4	3	theme	intensive	627:635	arg1	engineering					645:655	intensive genetic engineering	627:655	intensive genetic engineering toward this goal	627:672	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	5	4	theme	Trichoderma	824:834	arg1	species					836:842	other enzyme-producing Trichoderma species	801:842	other enzyme-producing Trichoderma species	801:842	However, the genetic manipulation of other enzyme-producing Trichoderma species is frequently less efficient and, therefore, rarely managed.
34009590	4	5	theme	plant-cell-wall-degrading	537:561	arg1	enzymes					563:569	plant-cell-wall-degrading enzymes	537:569	plant-cell-wall-degrading enzymes	537:569	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	4	6	theme	genetic	734:740	arg1	improvement					742:752	the successful genetic improvement	719:752	the successful genetic improvement of fungi	719:761	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	5	7	dep	efficient	863:871	arg1	managed					896:902	managed	896:902	managed	896:902	However, the genetic manipulation of other enzyme-producing Trichoderma species is frequently less efficient and, therefore, rarely managed.
34009590	5	7	dep	efficient	863:871	arg1	manipulation					785:796	the genetic manipulation	773:796	the genetic manipulation of other enzyme-producing Trichoderma species	773:842	However, the genetic manipulation of other enzyme-producing Trichoderma species is frequently less efficient and, therefore, rarely managed.
34009590	5	7	dep	efficient	863:871	arg1	efficient					863:871	efficient	863:871	efficient	863:871	However, the genetic manipulation of other enzyme-producing Trichoderma species is frequently less efficient and, therefore, rarely managed.
34009590	8	8	theme	reesei	1397:1402	arg1	mutants					1404:1410	T. reesei mutants	1394:1410	T. reesei mutants with particular properties	1394:1437	The protocols are simple, do not require extensive training or special equipment, and can be further adjusted for T. reesei mutants with particular properties.
34009590	6	9	dep	Agrobacterium	1053:1065	arg1	b					1050:1050	b	1050:1050	b	1050:1050	In this chapter, we therefore describe the two potent methods of Trichoderma transformation mediated by either (a) polyethylene glycol (PEG) or (b) Agrobacterium.
34009590	1	10	theme	biofuels	61:68	arg1	dependent					92:100	dependent	92:100	dependent	92:100	The production of biofuels from plant biomass is dependent on the availability of enzymes that can hydrolyze the plant cell wall polysaccharides to their monosaccharides.
34009590	1	10	theme	biofuels	61:68	arg1	production					47:56	The production	43:56	The production of biofuels from plant biomass	43:87	The production of biofuels from plant biomass is dependent on the availability of enzymes that can hydrolyze the plant cell wall polysaccharides to their monosaccharides.
34009590	4	11	theme	genetic	637:643	arg1	engineering					645:655	intensive genetic engineering	627:655	intensive genetic engineering toward this goal	627:672	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	3	12	theme	Genetic	347:353	arg1	engineering					355:365	Genetic engineering	347:365	Genetic engineering of these microorganisms	347:389	Genetic engineering of these microorganisms is therefore necessary, in which introduction of DNA is an essential precondition.
34009590	4	13	theme	filamentous	478:488	arg1	producer					525:532	The filamentous fungus Trichoderma reesei-the main producer	474:532	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has	474:607	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	2	14	theme	native	275:280	arg1	compositions					282:293	their native compositions	269:293	their native compositions	269:293	These enzyme mixtures are formed by microorganisms but their native compositions and properties are often not ideal for application.
34009590	1	15	theme	plant	156:160	arg1	polysaccharides					172:186	the plant cell wall polysaccharides	152:186	the plant cell wall polysaccharides	152:186	The production of biofuels from plant biomass is dependent on the availability of enzymes that can hydrolyze the plant cell wall polysaccharides to their monosaccharides.
34009590	6	16	theme	polyethylene	1020:1031	arg1	PEG					1041:1043	PEG	1041:1043	PEG	1041:1043	In this chapter, we therefore describe the two potent methods of Trichoderma transformation mediated by either (a) polyethylene glycol (PEG) or (b) Agrobacterium.
34009590	6	16	theme	polyethylene	1020:1031	arg1	glycol					1033:1038	polyethylene glycol	1020:1038	(a) polyethylene glycol (PEG)	1016:1044	In this chapter, we therefore describe the two potent methods of Trichoderma transformation mediated by either (a) polyethylene glycol (PEG) or (b) Agrobacterium.
34009590	4	17	theme	reesei-the	509:518	arg1	producer					525:532	The filamentous fungus Trichoderma reesei-the main producer	474:532	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has	474:607	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	1	18	theme	plant	75:79	arg1	biomass					81:87	plant biomass	75:87	plant biomass	75:87	The production of biofuels from plant biomass is dependent on the availability of enzymes that can hydrolyze the plant cell wall polysaccharides to their monosaccharides.
34009590	1	19	theme	cell	162:165	arg1	polysaccharides					172:186	the plant cell wall polysaccharides	152:186	the plant cell wall polysaccharides	152:186	The production of biofuels from plant biomass is dependent on the availability of enzymes that can hydrolyze the plant cell wall polysaccharides to their monosaccharides.
34009590	4	20	theme	Trichoderma	497:507	arg1	producer					525:532	The filamentous fungus Trichoderma reesei-the main producer	474:532	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has	474:607	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	7	21	theme	upcoming	1229:1236	arg1	species					1166:1172	such transformation-resilient species	1136:1172	such transformation-resilient species	1136:1172	The methods are optimized for T. reesei but can also be applied for such transformation-resilient species as T. harzianum and T. guizhouense, which are putative upcoming alternatives for T. reesei in this field.
34009590	7	21	theme	upcoming	1229:1236	arg1	alternatives					1238:1249	putative upcoming alternatives	1220:1249	putative upcoming alternatives for T. reesei	1220:1263	The methods are optimized for T. reesei but can also be applied for such transformation-resilient species as T. harzianum and T. guizhouense, which are putative upcoming alternatives for T. reesei in this field.
34009590	1	22	theme	wall	167:170	arg1	polysaccharides					172:186	the plant cell wall polysaccharides	152:186	the plant cell wall polysaccharides	152:186	The production of biofuels from plant biomass is dependent on the availability of enzymes that can hydrolyze the plant cell wall polysaccharides to their monosaccharides.
34009590	0	23	theme	Genetic	0:6	arg1	Transformation					8:21	Genetic Transformation	0:21	Genetic Transformation of Trichoderma	0:36	Genetic Transformation of Trichoderma spp.
34009590	4	24	theme	examples	707:714	arg1	one					689:691	one	689:691	one	689:691	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	4	24	theme	examples	707:714	arg1	examples					707:714	the iconic examples	696:714	the iconic examples of the successful genetic improvement of fungi	696:761	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	3	25	theme	microorganisms	376:389	arg1	engineering					355:365	Genetic engineering	347:365	Genetic engineering of these microorganisms	347:389	Genetic engineering of these microorganisms is therefore necessary, in which introduction of DNA is an essential precondition.
34009590	4	26	theme	other	588:592	arg1	industries-has					594:607	other industries-has	588:607	other industries-has	588:607	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	8	27	theme	extensive	1321:1329	arg1	training					1331:1338	extensive training	1321:1338	extensive training	1321:1338	The protocols are simple, do not require extensive training or special equipment, and can be further adjusted for T. reesei mutants with particular properties.
34009590	5	28	theme	species	836:842	arg1	managed					896:902	managed	896:902	managed	896:902	However, the genetic manipulation of other enzyme-producing Trichoderma species is frequently less efficient and, therefore, rarely managed.
34009590	5	28	theme	species	836:842	arg1	manipulation					785:796	the genetic manipulation	773:796	the genetic manipulation of other enzyme-producing Trichoderma species	773:842	However, the genetic manipulation of other enzyme-producing Trichoderma species is frequently less efficient and, therefore, rarely managed.
34009590	5	28	theme	species	836:842	arg1	efficient					863:871	efficient	863:871	efficient	863:871	However, the genetic manipulation of other enzyme-producing Trichoderma species is frequently less efficient and, therefore, rarely managed.
34009590	4	29	dep	filamentous	478:488	arg1	fungus					490:495	fungus	490:495	fungus	490:495	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	3	30	theme	DNA	440:442	arg1	precondition					460:471	an essential precondition	447:471	an essential precondition	447:471	Genetic engineering of these microorganisms is therefore necessary, in which introduction of DNA is an essential precondition.
34009590	3	30	theme	DNA	440:442	arg1	introduction					424:435	introduction	424:435	introduction of DNA	424:442	Genetic engineering of these microorganisms is therefore necessary, in which introduction of DNA is an essential precondition.
34009590	3	31	theme	essential	450:458	arg1	precondition					460:471	an essential precondition	447:471	an essential precondition	447:471	Genetic engineering of these microorganisms is therefore necessary, in which introduction of DNA is an essential precondition.
34009590	3	31	theme	essential	450:458	arg1	introduction					424:435	introduction	424:435	introduction of DNA	424:442	Genetic engineering of these microorganisms is therefore necessary, in which introduction of DNA is an essential precondition.
34009590	4	32	theme	iconic	700:705	arg1	examples					707:714	the iconic examples	696:714	the iconic examples of the successful genetic improvement of fungi	696:761	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	0	33	theme	Trichoderma	26:36	arg1	Transformation					8:21	Genetic Transformation	0:21	Genetic Transformation of Trichoderma	0:36	Genetic Transformation of Trichoderma spp.
34009590	8	34	with	mutants	1404:1410	arg1	properties					1428:1437	particular properties	1417:1437	particular properties	1417:1437	The protocols are simple, do not require extensive training or special equipment, and can be further adjusted for T. reesei mutants with particular properties.
34009590	7	35	theme	such	1136:1139	arg1	species					1166:1172	such transformation-resilient species	1136:1172	such transformation-resilient species	1136:1172	The methods are optimized for T. reesei but can also be applied for such transformation-resilient species as T. harzianum and T. guizhouense, which are putative upcoming alternatives for T. reesei in this field.
34009590	7	35	theme	such	1136:1139	arg1	alternatives					1238:1249	putative upcoming alternatives	1220:1249	putative upcoming alternatives for T. reesei	1220:1263	The methods are optimized for T. reesei but can also be applied for such transformation-resilient species as T. harzianum and T. guizhouense, which are putative upcoming alternatives for T. reesei in this field.
34009590	4	36	theme	enzymes	563:569	arg1	producer					525:532	The filamentous fungus Trichoderma reesei-the main producer	474:532	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has	474:607	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	2	37	theme	enzyme	220:225	arg1	mixtures					227:234	These enzyme mixtures	214:234	These enzyme mixtures	214:234	These enzyme mixtures are formed by microorganisms but their native compositions and properties are often not ideal for application.
34009590	3	38	from	precondition	460:471	arg1	which					418:422	which	418:422	which	418:422	Genetic engineering of these microorganisms is therefore necessary, in which introduction of DNA is an essential precondition.
34009590	4	39	theme	fungi	757:761	arg1	improvement					742:752	the successful genetic improvement	719:752	the successful genetic improvement of fungi	719:761	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	7	40	theme	transformation-resilient	1141:1164	arg1	species					1166:1172	such transformation-resilient species	1136:1172	such transformation-resilient species	1136:1172	The methods are optimized for T. reesei but can also be applied for such transformation-resilient species as T. harzianum and T. guizhouense, which are putative upcoming alternatives for T. reesei in this field.
34009590	7	40	theme	transformation-resilient	1141:1164	arg1	alternatives					1238:1249	putative upcoming alternatives	1220:1249	putative upcoming alternatives for T. reesei	1220:1263	The methods are optimized for T. reesei but can also be applied for such transformation-resilient species as T. harzianum and T. guizhouense, which are putative upcoming alternatives for T. reesei in this field.
34009590	6	41	theme	transformation	982:995	arg1	methods					959:965	the two potent methods	944:965	the two potent methods of Trichoderma transformation mediated by either (a) polyethylene glycol (PEG) or (b) Agrobacterium	944:1065	In this chapter, we therefore describe the two potent methods of Trichoderma transformation mediated by either (a) polyethylene glycol (PEG) or (b) Agrobacterium.
34009590	6	42	theme	potent	952:957	arg1	methods					959:965	the two potent methods	944:965	the two potent methods of Trichoderma transformation mediated by either (a) polyethylene glycol (PEG) or (b) Agrobacterium	944:1065	In this chapter, we therefore describe the two potent methods of Trichoderma transformation mediated by either (a) polyethylene glycol (PEG) or (b) Agrobacterium.
34009590	8	43	theme	T.	1394:1395	arg1	mutants					1404:1410	T. reesei mutants	1394:1410	T. reesei mutants with particular properties	1394:1437	The protocols are simple, do not require extensive training or special equipment, and can be further adjusted for T. reesei mutants with particular properties.
34009590	6	44	theme	Trichoderma	970:980	arg1	transformation					982:995	Trichoderma transformation	970:995	Trichoderma transformation mediated by either (a) polyethylene glycol (PEG) or (b) Agrobacterium	970:1065	In this chapter, we therefore describe the two potent methods of Trichoderma transformation mediated by either (a) polyethylene glycol (PEG) or (b) Agrobacterium.
34009590	5	45	theme	genetic	777:783	arg1	managed					896:902	managed	896:902	managed	896:902	However, the genetic manipulation of other enzyme-producing Trichoderma species is frequently less efficient and, therefore, rarely managed.
34009590	5	45	theme	genetic	777:783	arg1	manipulation					785:796	the genetic manipulation	773:796	the genetic manipulation of other enzyme-producing Trichoderma species	773:842	However, the genetic manipulation of other enzyme-producing Trichoderma species is frequently less efficient and, therefore, rarely managed.
34009590	5	45	theme	genetic	777:783	arg1	efficient					863:871	efficient	863:871	efficient	863:871	However, the genetic manipulation of other enzyme-producing Trichoderma species is frequently less efficient and, therefore, rarely managed.
34009590	7	46	theme	putative	1220:1227	arg1	species					1166:1172	such transformation-resilient species	1136:1172	such transformation-resilient species	1136:1172	The methods are optimized for T. reesei but can also be applied for such transformation-resilient species as T. harzianum and T. guizhouense, which are putative upcoming alternatives for T. reesei in this field.
34009590	7	46	theme	putative	1220:1227	arg1	alternatives					1238:1249	putative upcoming alternatives	1220:1249	putative upcoming alternatives for T. reesei	1220:1263	The methods are optimized for T. reesei but can also be applied for such transformation-resilient species as T. harzianum and T. guizhouense, which are putative upcoming alternatives for T. reesei in this field.
34009590	7	47	from	alternatives	1238:1249	arg1	field					1273:1277	this field	1268:1277	this field	1268:1277	The methods are optimized for T. reesei but can also be applied for such transformation-resilient species as T. harzianum and T. guizhouense, which are putative upcoming alternatives for T. reesei in this field.
34009590	8	48	theme	special	1343:1349	arg1	equipment					1351:1359	special equipment	1343:1359	special equipment	1343:1359	The protocols are simple, do not require extensive training or special equipment, and can be further adjusted for T. reesei mutants with particular properties.
34009590	1	49	theme	enzymes	125:131	arg1	availability					109:120	the availability	105:120	the availability of enzymes that can hydrolyze the plant cell wall polysaccharides to their monosaccharides	105:211	The production of biofuels from plant biomass is dependent on the availability of enzymes that can hydrolyze the plant cell wall polysaccharides to their monosaccharides.
34009590	1	50	from	biomass	81:87	arg1	dependent					92:100	dependent	92:100	dependent	92:100	The production of biofuels from plant biomass is dependent on the availability of enzymes that can hydrolyze the plant cell wall polysaccharides to their monosaccharides.
34009590	1	50	from	biomass	81:87	arg1	production					47:56	The production	43:56	The production of biofuels from plant biomass	43:87	The production of biofuels from plant biomass is dependent on the availability of enzymes that can hydrolyze the plant cell wall polysaccharides to their monosaccharides.
34009590	4	51	theme	successful	723:732	arg1	improvement					742:752	the successful genetic improvement	719:752	the successful genetic improvement of fungi	719:761	The filamentous fungus Trichoderma reesei-the main producer of plant-cell-wall-degrading enzymes for biofuels and other industries-has been subjected to intensive genetic engineering toward this goal and has become one of the iconic examples of the successful genetic improvement of fungi.
34009590	5	52	theme	other	801:805	arg1	species					836:842	other enzyme-producing Trichoderma species	801:842	other enzyme-producing Trichoderma species	801:842	However, the genetic manipulation of other enzyme-producing Trichoderma species is frequently less efficient and, therefore, rarely managed.
34009590	6	53	dep	glycol	1033:1038	arg1	a					1017:1017	a	1017:1017	a	1017:1017	In this chapter, we therefore describe the two potent methods of Trichoderma transformation mediated by either (a) polyethylene glycol (PEG) or (b) Agrobacterium.
34009590	8	54	theme	particular	1417:1426	arg1	properties					1428:1437	particular properties	1417:1437	particular properties	1417:1437	The protocols are simple, do not require extensive training or special equipment, and can be further adjusted for T. reesei mutants with particular properties.
33113735	1	0	theme	co-precipitation	175:190	arg1	method					192:197	a co-precipitation method	173:197	a co-precipitation method	173:197	Using a co-precipitation method, starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites were synthesized.
33113735	7	1	theme	noticeable	1206:1215	arg1	change					1217:1222	a noticeable change	1204:1222	a noticeable change in performance (e.g., up to 30 cycles) and target recoveries between 99.5 - 82.9 %	1204:1305	In addition, each LDH-SPE cartridge showed good reusability without a noticeable change in performance (e.g., up to 30 cycles) and target recoveries between 99.5 - 82.9 %.
33113735	3	2	theme	waste	576:580	arg1	water					582:586	hospital waste water	567:586	hospital waste water	567:586	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	0	3	theme	non-steroidal	100:112	arg1	drugs					132:136	non-steroidal anti-inflammatory drugs	100:136	non-steroidal anti-inflammatory drugs as environmental pollutants	100:164	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction sorbent for non-steroidal anti-inflammatory drugs as environmental pollutants.
33113735	7	4	theme	target	1267:1272	arg1	recoveries					1274:1283	target recoveries	1267:1283	target recoveries between 99.5 - 82.9 %	1267:1305	In addition, each LDH-SPE cartridge showed good reusability without a noticeable change in performance (e.g., up to 30 cycles) and target recoveries between 99.5 - 82.9 %.
33113735	2	5	theme	Fourier-transform	331:347	arg1	spectroscopy					358:369	Fourier-transform infrared spectroscopy	331:369	Fourier-transform infrared spectroscopy	331:369	Their physicochemical properties were assessed by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and thermo-gravimetric analysis.
33113735	3	6	theme	plant	619:623	arg1	water					625:629	sewage treatment plant water	602:629	sewage treatment plant water	602:629	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	4	7	theme	variables	783:791	arg1	terms					762:766	terms	762:766	terms of several key variables (e.g., pH, flow rate, and eluent type/volume)	762:837	For the development of this method, the system was optimized in terms of several key variables (e.g., pH, flow rate, and eluent type/volume).
33113735	3	8	theme	sewage	602:607	arg1	water					625:629	sewage treatment plant water	602:629	sewage treatment plant water	602:629	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	8	9	theme	new	1333:1335	arg1	opportunities					1337:1349	new opportunities	1333:1349	new opportunities	1333:1349	This work should open up new opportunities for a sesnsitive and sustainable quantitative method for the determination of NSAIDs in complex samples.
33113735	3	10	theme	hospital	567:574	arg1	water					582:586	hospital waste water	567:586	hospital waste water	567:586	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	7	11	dep	30	1252:1253	arg1	to					1249:1250	to	1249:1250	to	1249:1250	In addition, each LDH-SPE cartridge showed good reusability without a noticeable change in performance (e.g., up to 30 cycles) and target recoveries between 99.5 - 82.9 %.
33113735	6	12	theme	phase	1092:1096	arg1	extraction					1098:1107	solid phase extraction	1086:1107	efficient and fast solid phase extraction (SPE) sorbents for NSAIDs	1067:1133	Hence, S-Mg/Al LDH composites were proven to be efficient and fast solid phase extraction (SPE) sorbents for NSAIDs.
33113735	6	12	theme	phase	1092:1096	arg1	SPE					1110:1112	SPE	1110:1112	SPE	1110:1112	Hence, S-Mg/Al LDH composites were proven to be efficient and fast solid phase extraction (SPE) sorbents for NSAIDs.
33113735	3	13	theme	river	589:593	arg1	water					595:599	river water	589:599	river water	589:599	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	3	14	theme	drugs	512:516	arg1	quantification					458:471	The quantification	454:471	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs)	454:525	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	6	15	theme	fast	1081:1084	arg1	sorbents					1115:1122	efficient and fast solid phase extraction (SPE) sorbents	1067:1122	efficient and fast solid phase extraction (SPE) sorbents for NSAIDs	1067:1133	Hence, S-Mg/Al LDH composites were proven to be efficient and fast solid phase extraction (SPE) sorbents for NSAIDs.
33113735	0	16	theme	anti-inflammatory	114:130	arg1	drugs					132:136	non-steroidal anti-inflammatory drugs	100:136	non-steroidal anti-inflammatory drugs as environmental pollutants	100:164	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction sorbent for non-steroidal anti-inflammatory drugs as environmental pollutants.
33113735	8	17	from	NSAIDs	1429:1434	arg1	samples					1447:1453	complex samples	1439:1453	complex samples	1439:1453	This work should open up new opportunities for a sesnsitive and sustainable quantitative method for the determination of NSAIDs in complex samples.
33113735	5	18	theme	complex	953:959	arg1	matrices					961:968	complex matrices	953:968	complex matrices with limits of detection between 4 and 20 pg/mL	953:1016	The developed method for NSAIDs exhibited good resolution, sensitivity, reproducibility, and specificity even in complex matrices with limits of detection between 4 and 20 pg/mL.
33113735	5	19	with	matrices	961:968	arg1	limits					975:980	limits	975:980	limits of detection between 4 and 20 pg/mL	975:1016	The developed method for NSAIDs exhibited good resolution, sensitivity, reproducibility, and specificity even in complex matrices with limits of detection between 4 and 20 pg/mL.
33113735	1	20	theme	starch-Mg/Al	200:211	arg1	composites					252:261	starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites	200:261	starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites	200:261	Using a co-precipitation method, starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites were synthesized.
33113735	0	21	theme	layered	13:19	arg1	composites					38:47	Starch-Mg/Al layered double hydroxide composites	0:47	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction	0:86	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction sorbent for non-steroidal anti-inflammatory drugs as environmental pollutants.
33113735	2	22	theme	X-ray	372:376	arg1	diffraction					378:388	X-ray diffraction	372:388	X-ray diffraction	372:388	Their physicochemical properties were assessed by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and thermo-gravimetric analysis.
33113735	6	23	theme	solid	1086:1090	arg1	extraction					1098:1107	solid phase extraction	1086:1107	efficient and fast solid phase extraction (SPE) sorbents for NSAIDs	1067:1133	Hence, S-Mg/Al LDH composites were proven to be efficient and fast solid phase extraction (SPE) sorbents for NSAIDs.
33113735	6	23	theme	solid	1086:1090	arg1	SPE					1110:1112	SPE	1110:1112	SPE	1110:1112	Hence, S-Mg/Al LDH composites were proven to be efficient and fast solid phase extraction (SPE) sorbents for NSAIDs.
33113735	1	24	theme	layered	213:219	arg1	hydroxide					228:236	layered double hydroxide	213:236	starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites	200:261	Using a co-precipitation method, starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites were synthesized.
33113735	1	24	theme	layered	213:219	arg1	LDH					247:249	S-Mg/Al LDH	239:249	S-Mg/Al LDH	239:249	Using a co-precipitation method, starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites were synthesized.
33113735	0	25	theme	Starch-Mg/Al	0:11	arg1	composites					38:47	Starch-Mg/Al layered double hydroxide composites	0:47	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction	0:86	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction sorbent for non-steroidal anti-inflammatory drugs as environmental pollutants.
33113735	4	26	theme	key	779:781	arg1	variables					783:791	several key variables	771:791	several key variables (e.g., pH, flow rate, and eluent type/volume)	771:837	For the development of this method, the system was optimized in terms of several key variables (e.g., pH, flow rate, and eluent type/volume).
33113735	1	27	theme	double	221:226	arg1	hydroxide					228:236	layered double hydroxide	213:236	starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites	200:261	Using a co-precipitation method, starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites were synthesized.
33113735	1	27	theme	double	221:226	arg1	LDH					247:249	S-Mg/Al LDH	239:249	S-Mg/Al LDH	239:249	Using a co-precipitation method, starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites were synthesized.
33113735	0	28	theme	hydroxide	28:36	arg1	composites					38:47	Starch-Mg/Al layered double hydroxide composites	0:47	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction	0:86	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction sorbent for non-steroidal anti-inflammatory drugs as environmental pollutants.
33113735	0	29	theme	environmental	141:153	arg1	pollutants					155:164	environmental pollutants	141:164	environmental pollutants	141:164	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction sorbent for non-steroidal anti-inflammatory drugs as environmental pollutants.
33113735	3	30	theme	treatment	609:617	arg1	water					625:629	sewage treatment plant water	602:629	sewage treatment plant water	602:629	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	1	31	theme	hydroxide	228:236	arg1	composites					252:261	starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites	200:261	starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites	200:261	Using a co-precipitation method, starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites were synthesized.
33113735	0	32	theme	double	21:26	arg1	composites					38:47	Starch-Mg/Al layered double hydroxide composites	0:47	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction	0:86	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction sorbent for non-steroidal anti-inflammatory drugs as environmental pollutants.
33113735	4	33	theme	flow	804:807	arg1	rate					809:812	flow rate	804:812	flow rate	804:812	For the development of this method, the system was optimized in terms of several key variables (e.g., pH, flow rate, and eluent type/volume).
33113735	2	34	theme	infrared	349:356	arg1	spectroscopy					358:369	Fourier-transform infrared spectroscopy	331:369	Fourier-transform infrared spectroscopy	331:369	Their physicochemical properties were assessed by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and thermo-gravimetric analysis.
33113735	3	35	theme	real	547:550	arg1	samples					552:558	real samples	547:558	real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations)	547:655	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	3	36	theme	non-steroidal	480:492	arg1	NSAIDs					519:524	NSAIDs	519:524	NSAIDs	519:524	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	3	36	theme	non-steroidal	480:492	arg1	drugs					512:516	six non-steroidal anti-inflammatory drugs	476:516	six non-steroidal anti-inflammatory drugs (NSAIDs)	476:525	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	4	37	dep	pH	800:801	arg1	e.g.					794:797	e.g.	794:797	e.g.	794:797	For the development of this method, the system was optimized in terms of several key variables (e.g., pH, flow rate, and eluent type/volume).
33113735	4	38	theme	method	726:731	arg1	development					706:716	the development	702:716	the development of this method	702:731	For the development of this method, the system was optimized in terms of several key variables (e.g., pH, flow rate, and eluent type/volume).
33113735	1	39	theme	S-Mg/Al	239:245	arg1	hydroxide					228:236	layered double hydroxide	213:236	starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites	200:261	Using a co-precipitation method, starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites were synthesized.
33113735	1	39	theme	S-Mg/Al	239:245	arg1	LDH					247:249	S-Mg/Al LDH	239:249	S-Mg/Al LDH	239:249	Using a co-precipitation method, starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites were synthesized.
33113735	3	40	theme	anti-inflammatory	494:510	arg1	NSAIDs					519:524	NSAIDs	519:524	NSAIDs	519:524	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	3	40	theme	anti-inflammatory	494:510	arg1	drugs					512:516	six non-steroidal anti-inflammatory drugs	476:516	six non-steroidal anti-inflammatory drugs (NSAIDs)	476:525	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	6	41	theme	efficient	1067:1075	arg1	sorbents					1115:1122	efficient and fast solid phase extraction (SPE) sorbents	1067:1122	efficient and fast solid phase extraction (SPE) sorbents for NSAIDs	1067:1133	Hence, S-Mg/Al LDH composites were proven to be efficient and fast solid phase extraction (SPE) sorbents for NSAIDs.
33113735	0	42	theme	efficient	55:63	arg1	extraction					77:86	an efficient solid phase extraction	52:86	an efficient solid phase extraction	52:86	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction sorbent for non-steroidal anti-inflammatory drugs as environmental pollutants.
33113735	8	43	from	samples	1447:1453	arg1	determination					1412:1424	the determination	1408:1424	the determination of NSAIDs in complex samples	1408:1453	This work should open up new opportunities for a sesnsitive and sustainable quantitative method for the determination of NSAIDs in complex samples.
33113735	8	44	from	determination	1412:1424	arg1	samples					1447:1453	complex samples	1439:1453	complex samples	1439:1453	This work should open up new opportunities for a sesnsitive and sustainable quantitative method for the determination of NSAIDs in complex samples.
33113735	5	45	theme	detection	985:993	arg1	limits					975:980	limits	975:980	limits of detection between 4 and 20 pg/mL	975:1016	The developed method for NSAIDs exhibited good resolution, sensitivity, reproducibility, and specificity even in complex matrices with limits of detection between 4 and 20 pg/mL.
33113735	2	46	theme	electron	400:407	arg1	microscopy					409:418	scanning electron microscopy	391:418	scanning electron microscopy	391:418	Their physicochemical properties were assessed by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and thermo-gravimetric analysis.
33113735	8	47	theme	sesnsitive	1357:1366	arg1	method					1397:1402	a sesnsitive and sustainable quantitative method	1355:1402	a sesnsitive and sustainable quantitative method for the determination of NSAIDs in complex samples	1355:1453	This work should open up new opportunities for a sesnsitive and sustainable quantitative method for the determination of NSAIDs in complex samples.
33113735	7	48	theme	good	1179:1182	arg1	reusability					1184:1194	good reusability	1179:1194	good reusability	1179:1194	In addition, each LDH-SPE cartridge showed good reusability without a noticeable change in performance (e.g., up to 30 cycles) and target recoveries between 99.5 - 82.9 %.
33113735	3	49	theme	tablet	636:641	arg1	formulations					643:654	tablet formulations	636:654	tablet formulations	636:654	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	2	50	theme	scanning	391:398	arg1	microscopy					409:418	scanning electron microscopy	391:418	scanning electron microscopy	391:418	Their physicochemical properties were assessed by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and thermo-gravimetric analysis.
33113735	8	51	theme	sustainable	1372:1382	arg1	method					1397:1402	a sesnsitive and sustainable quantitative method	1355:1402	a sesnsitive and sustainable quantitative method for the determination of NSAIDs in complex samples	1355:1453	This work should open up new opportunities for a sesnsitive and sustainable quantitative method for the determination of NSAIDs in complex samples.
33113735	8	52	theme	quantitative	1384:1395	arg1	method					1397:1402	a sesnsitive and sustainable quantitative method	1355:1402	a sesnsitive and sustainable quantitative method for the determination of NSAIDs in complex samples	1355:1453	This work should open up new opportunities for a sesnsitive and sustainable quantitative method for the determination of NSAIDs in complex samples.
33113735	7	53	theme	LDH-SPE	1154:1160	arg1	cartridge					1162:1170	each LDH-SPE cartridge	1149:1170	each LDH-SPE cartridge	1149:1170	In addition, each LDH-SPE cartridge showed good reusability without a noticeable change in performance (e.g., up to 30 cycles) and target recoveries between 99.5 - 82.9 %.
33113735	3	54	theme	chromatography-mass	664:682	arg1	spectrometry					684:695	gas chromatography-mass spectrometry	660:695	gas chromatography-mass spectrometry	660:695	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	4	55	theme	several	771:777	arg1	variables					783:791	several key variables	771:791	several key variables (e.g., pH, flow rate, and eluent type/volume)	771:837	For the development of this method, the system was optimized in terms of several key variables (e.g., pH, flow rate, and eluent type/volume).
33113735	3	56	dep	water	582:586	arg1	e.g.					561:564	e.g.	561:564	e.g.	561:564	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	6	57	theme	LDH	1034:1036	arg1	composites					1038:1047	S-Mg/Al LDH composites	1026:1047	S-Mg/Al LDH composites	1026:1047	Hence, S-Mg/Al LDH composites were proven to be efficient and fast solid phase extraction (SPE) sorbents for NSAIDs.
33113735	7	58	dep	cycles	1255:1260	arg1	e.g.					1240:1243	e.g.	1240:1243	e.g.	1240:1243	In addition, each LDH-SPE cartridge showed good reusability without a noticeable change in performance (e.g., up to 30 cycles) and target recoveries between 99.5 - 82.9 %.
33113735	7	59	from	change	1217:1222	arg1	performance					1227:1237	performance	1227:1237	performance (e.g., up to 30 cycles)	1227:1261	In addition, each LDH-SPE cartridge showed good reusability without a noticeable change in performance (e.g., up to 30 cycles) and target recoveries between 99.5 - 82.9 %.
33113735	7	59	from	change	1217:1222	arg1	recoveries					1274:1283	target recoveries	1267:1283	target recoveries between 99.5 - 82.9 %	1267:1305	In addition, each LDH-SPE cartridge showed good reusability without a noticeable change in performance (e.g., up to 30 cycles) and target recoveries between 99.5 - 82.9 %.
33113735	7	59	from	change	1217:1222	arg1	cycles					1255:1260	up to 30 cycles	1246:1260	up to 30 cycles	1246:1260	In addition, each LDH-SPE cartridge showed good reusability without a noticeable change in performance (e.g., up to 30 cycles) and target recoveries between 99.5 - 82.9 %.
33113735	2	60	theme	physicochemical	287:301	arg1	properties					303:312	Their physicochemical properties	281:312	Their physicochemical properties	281:312	Their physicochemical properties were assessed by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and thermo-gravimetric analysis.
33113735	8	61	theme	NSAIDs	1429:1434	arg1	determination					1412:1424	the determination	1408:1424	the determination of NSAIDs in complex samples	1408:1453	This work should open up new opportunities for a sesnsitive and sustainable quantitative method for the determination of NSAIDs in complex samples.
33113735	6	62	theme	S-Mg/Al	1026:1032	arg1	composites					1038:1047	S-Mg/Al LDH composites	1026:1047	S-Mg/Al LDH composites	1026:1047	Hence, S-Mg/Al LDH composites were proven to be efficient and fast solid phase extraction (SPE) sorbents for NSAIDs.
33113735	0	63	theme	phase	71:75	arg1	extraction					77:86	an efficient solid phase extraction	52:86	an efficient solid phase extraction	52:86	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction sorbent for non-steroidal anti-inflammatory drugs as environmental pollutants.
33113735	8	64	theme	complex	1439:1445	arg1	samples					1447:1453	complex samples	1439:1453	complex samples	1439:1453	This work should open up new opportunities for a sesnsitive and sustainable quantitative method for the determination of NSAIDs in complex samples.
33113735	4	65	theme	eluent	819:824	arg1	type/volume					826:836	eluent type/volume	819:836	eluent type/volume	819:836	For the development of this method, the system was optimized in terms of several key variables (e.g., pH, flow rate, and eluent type/volume).
33113735	5	66	theme	developed	844:852	arg1	method					854:859	The developed method	840:859	The developed method for NSAIDs	840:870	The developed method for NSAIDs exhibited good resolution, sensitivity, reproducibility, and specificity even in complex matrices with limits of detection between 4 and 20 pg/mL.
33113735	2	67	theme	thermo-gravimetric	425:442	arg1	analysis					444:451	thermo-gravimetric analysis	425:451	thermo-gravimetric analysis	425:451	Their physicochemical properties were assessed by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and thermo-gravimetric analysis.
33113735	5	68	theme	good	882:885	arg1	resolution					887:896	good resolution	882:896	good resolution	882:896	The developed method for NSAIDs exhibited good resolution, sensitivity, reproducibility, and specificity even in complex matrices with limits of detection between 4 and 20 pg/mL.
33113735	0	69	theme	solid	65:69	arg1	extraction					77:86	an efficient solid phase extraction	52:86	an efficient solid phase extraction	52:86	Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction sorbent for non-steroidal anti-inflammatory drugs as environmental pollutants.
33113735	3	70	theme	gas	660:662	arg1	spectrometry					684:695	gas chromatography-mass spectrometry	660:695	gas chromatography-mass spectrometry	660:695	The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry.
33113735	6	71	theme	extraction	1098:1107	arg1	sorbents					1115:1122	efficient and fast solid phase extraction (SPE) sorbents	1067:1122	efficient and fast solid phase extraction (SPE) sorbents for NSAIDs	1067:1133	Hence, S-Mg/Al LDH composites were proven to be efficient and fast solid phase extraction (SPE) sorbents for NSAIDs.
34444552	4	0	theme	adsorption	844:853	arg1	capacities					855:864	The maximum adsorption capacities	832:864	The maximum adsorption capacities of the SCM beads	832:881	The maximum adsorption capacities of the SCM beads were 75.7 and 232.8 mmol/kg for As and Pb, respectively, which were 40 and 5.6 times higher than that of SP according to the Langmuir model analyses.
34444552	4	0	theme	adsorption	844:853	arg1	mmol/kg					903:909	75.7 and 232.8 mmol/kg	888:909	75.7 and 232.8 mmol/kg for As and Pb	888:923	The maximum adsorption capacities of the SCM beads were 75.7 and 232.8 mmol/kg for As and Pb, respectively, which were 40 and 5.6 times higher than that of SP according to the Langmuir model analyses.
34444552	2	1	with	chitosan	308:315	arg1	ratios					365:370	different weight ratios	348:370	different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag)	348:416	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	2	2	dep	ratios	365:370	arg1	1/1/0.3					382:388	1/1/0.3	382:388	1/1/0.3	382:388	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	2	2	dep	ratios	365:370	arg1	1/1/0.5					395:401	1/1/0.5	395:401	1/1/0.5	395:401	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	1	3	dep	Arsenic	91:97	arg1	contamination					118:130	contamination	118:130	contamination	118:130	Arsenic (As) and lead (Pb) contamination in groundwater is a serious problem in countries that use groundwater as drinking water.
34444552	1	3	dep	Arsenic	91:97	arg1	As					100:101	As	100:101	As	100:101	Arsenic (As) and lead (Pb) contamination in groundwater is a serious problem in countries that use groundwater as drinking water.
34444552	5	4	theme	different	1203:1211	arg1	affinities					1224:1233	different adsorption affinities	1203:1233	different adsorption affinities	1203:1233	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	3	5	theme	Pb	587:588	arg1	experiments					565:575	Adsorption isotherm experiments	545:575	Adsorption isotherm experiments of As and Pb onto the beads	545:603	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	3	6	theme	mode	735:738	arg1	models					745:750	the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	673:750	the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	673:750	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	3	7	theme	As	580:581	arg1	experiments					565:575	Adsorption isotherm experiments	545:575	Adsorption isotherm experiments of As and Pb onto the beads	545:603	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	2	8	theme	water	530:534	arg1	samples					536:542	artificially contaminated water samples	504:542	artificially contaminated water samples	504:542	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	5	9	theme	determinant	1071:1081	arg1	values					1100:1105	the highest determinant coefficient (R2) values	1059:1105	the highest determinant coefficient (R2) values for both As and Pb adsorption	1059:1135	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	4	10	theme	maximum	836:842	arg1	capacities					855:864	The maximum adsorption capacities	832:864	The maximum adsorption capacities of the SCM beads	832:881	The maximum adsorption capacities of the SCM beads were 75.7 and 232.8 mmol/kg for As and Pb, respectively, which were 40 and 5.6 times higher than that of SP according to the Langmuir model analyses.
34444552	4	10	theme	maximum	836:842	arg1	mmol/kg					903:909	75.7 and 232.8 mmol/kg	888:909	75.7 and 232.8 mmol/kg for As and Pb	888:923	The maximum adsorption capacities of the SCM beads were 75.7 and 232.8 mmol/kg for As and Pb, respectively, which were 40 and 5.6 times higher than that of SP according to the Langmuir model analyses.
34444552	2	11	theme	contaminated	517:528	arg1	samples					536:542	artificially contaminated water samples	504:542	artificially contaminated water samples	504:542	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	3	12	theme	Dubinin-Radushkevich	699:718	arg1	models					745:750	the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	673:750	the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	673:750	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	5	13	theme	adsorption	1213:1222	arg1	affinities					1224:1233	different adsorption affinities	1203:1233	different adsorption affinities	1203:1233	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	2	14	theme	composite	236:244	arg1	beads					246:250	composite beads	236:250	composite beads	236:250	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	2	14	theme	composite	236:244	arg1	beads					264:268	called SCM beads	253:268	called SCM beads	253:268	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	5	15	theme	R2	1096:1097	arg1	values					1100:1105	the highest determinant coefficient (R2) values	1059:1105	the highest determinant coefficient (R2) values for both As and Pb adsorption	1059:1135	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	4	16	theme	beads	877:881	arg1	capacities					855:864	The maximum adsorption capacities	832:864	The maximum adsorption capacities of the SCM beads	832:881	The maximum adsorption capacities of the SCM beads were 75.7 and 232.8 mmol/kg for As and Pb, respectively, which were 40 and 5.6 times higher than that of SP according to the Langmuir model analyses.
34444552	4	16	theme	beads	877:881	arg1	mmol/kg					903:909	75.7 and 232.8 mmol/kg	888:909	75.7 and 232.8 mmol/kg for As and Pb	888:923	The maximum adsorption capacities of the SCM beads were 75.7 and 232.8 mmol/kg for As and Pb, respectively, which were 40 and 5.6 times higher than that of SP according to the Langmuir model analyses.
34444552	2	17	theme	different	348:356	arg1	ratios					365:370	different weight ratios	348:370	different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag)	348:416	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	2	18	with	maghemite	327:335	arg1	ratios					365:370	different weight ratios	348:370	different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag)	348:416	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	4	19	theme	model	1017:1021	arg1	analyses					1023:1030	the Langmuir model analyses	1004:1030	the Langmuir model analyses	1004:1030	The maximum adsorption capacities of the SCM beads were 75.7 and 232.8 mmol/kg for As and Pb, respectively, which were 40 and 5.6 times higher than that of SP according to the Langmuir model analyses.
34444552	1	20	theme	serious	152:158	arg1	problem					160:166	a serious problem	150:166	a serious problem in countries that use groundwater as drinking water	150:218	Arsenic (As) and lead (Pb) contamination in groundwater is a serious problem in countries that use groundwater as drinking water.
34444552	1	20	theme	serious	152:158	arg1	lead					108:111	lead	108:111	lead (Pb)	108:116	Arsenic (As) and lead (Pb) contamination in groundwater is a serious problem in countries that use groundwater as drinking water.
34444552	1	20	theme	serious	152:158	arg1	Arsenic					91:97	Arsenic	91:97	Arsenic (As)	91:102	Arsenic (As) and lead (Pb) contamination in groundwater is a serious problem in countries that use groundwater as drinking water.
34444552	0	21	theme	Adsorptive	0:9	arg1	Removal					11:17	Adsorptive Removal	0:17	Adsorptive Removal of Arsenic and Lead by Stone Powder/Chitosan/Maghemite Composite Beads.	0:89	Adsorptive Removal of Arsenic and Lead by Stone Powder/Chitosan/Maghemite Composite Beads.
34444552	3	22	theme	single-solute	624:636	arg1	models					658:663	single-solute adsorption isotherm models	624:663	single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	624:750	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	3	22	theme	single-solute	624:636	arg1	models					745:750	the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	673:750	the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	673:750	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	4	23	theme	SCM	873:875	arg1	beads					877:881	the SCM beads	869:881	the SCM beads	869:881	The maximum adsorption capacities of the SCM beads were 75.7 and 232.8 mmol/kg for As and Pb, respectively, which were 40 and 5.6 times higher than that of SP according to the Langmuir model analyses.
34444552	0	24	theme	Arsenic	22:28	arg1	Removal					11:17	Adsorptive Removal	0:17	Adsorptive Removal of Arsenic and Lead by Stone Powder/Chitosan/Maghemite Composite Beads.	0:89	Adsorptive Removal of Arsenic and Lead by Stone Powder/Chitosan/Maghemite Composite Beads.
34444552	3	25	theme	adsorption	638:647	arg1	models					658:663	single-solute adsorption isotherm models	624:663	single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	624:750	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	3	25	theme	adsorption	638:647	arg1	models					745:750	the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	673:750	the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	673:750	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	1	26	from	lead	108:111	arg1	groundwater					135:145	groundwater	135:145	groundwater	135:145	Arsenic (As) and lead (Pb) contamination in groundwater is a serious problem in countries that use groundwater as drinking water.
34444552	2	27	theme	SCM	260:262	arg1	beads					246:250	composite beads	236:250	composite beads	236:250	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	2	27	theme	SCM	260:262	arg1	beads					264:268	called SCM beads	253:268	called SCM beads	253:268	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	6	28	theme	magnetic	1242:1249	arg1	beads					1251:1255	These magnetic beads	1236:1255	These magnetic beads	1236:1255	These magnetic beads could be utilized to treat contaminated groundwater.
34444552	5	29	dep	As	1116:1117	arg1	adsorption					1126:1135	adsorption	1126:1135	adsorption	1126:1135	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	5	30	theme	adsorption	1181:1190	arg1	sites					1192:1196	heterogenous adsorption sites	1168:1196	heterogenous adsorption sites	1168:1196	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	2	31	theme	called	253:258	arg1	beads					246:250	composite beads	236:250	composite beads	236:250	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	2	31	theme	called	253:258	arg1	beads					264:268	called SCM beads	253:268	called SCM beads	253:268	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	6	32	theme	contaminated	1284:1295	arg1	groundwater					1297:1307	contaminated groundwater	1284:1307	contaminated groundwater	1284:1307	These magnetic beads could be utilized to treat contaminated groundwater.
34444552	0	33	theme	Lead	34:37	arg1	Removal					11:17	Adsorptive Removal	0:17	Adsorptive Removal of Arsenic and Lead by Stone Powder/Chitosan/Maghemite Composite Beads.	0:89	Adsorptive Removal of Arsenic and Lead by Stone Powder/Chitosan/Maghemite Composite Beads.
34444552	5	34	theme	highest	1063:1069	arg1	values					1100:1105	the highest determinant coefficient (R2) values	1059:1105	the highest determinant coefficient (R2) values for both As and Pb adsorption	1059:1135	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	3	35	theme	experimental	771:782	arg1	data					784:787	the experimental data	767:787	the experimental data	767:787	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	2	36	with	powder	295:300	arg1	ratios					365:370	different weight ratios	348:370	different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag)	348:416	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	3	37	theme	adsorption	804:813	arg1	characteristics					815:829	the adsorption characteristics	800:829	the adsorption characteristics	800:829	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	0	38	theme	Stone	42:46	arg1	Beads					84:88	Stone Powder/Chitosan/Maghemite Composite Beads	42:88	Stone Powder/Chitosan/Maghemite Composite Beads	42:88	Adsorptive Removal of Arsenic and Lead by Stone Powder/Chitosan/Maghemite Composite Beads.
34444552	6	39	used	utilized	1266:1273	arg2	beads					1251:1255	These magnetic beads	1236:1255	These magnetic beads	1236:1255	These magnetic beads could be utilized to treat contaminated groundwater.
34444552	5	40	theme	heterogenous	1168:1179	arg1	sites					1192:1196	heterogenous adsorption sites	1168:1196	heterogenous adsorption sites	1168:1196	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	4	41	dep	mmol/kg	903:909	arg1	40					951:952	40	951:952	40	951:952	The maximum adsorption capacities of the SCM beads were 75.7 and 232.8 mmol/kg for As and Pb, respectively, which were 40 and 5.6 times higher than that of SP according to the Langmuir model analyses.
34444552	4	41	dep	mmol/kg	903:909	arg1	times					962:966	times	962:966	times	962:966	The maximum adsorption capacities of the SCM beads were 75.7 and 232.8 mmol/kg for As and Pb, respectively, which were 40 and 5.6 times higher than that of SP according to the Langmuir model analyses.
34444552	2	42	theme	weight	358:363	arg1	ratios					365:370	different weight ratios	348:370	different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag)	348:416	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	3	43	theme	isotherm	649:656	arg1	models					658:663	single-solute adsorption isotherm models	624:663	single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	624:750	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	3	43	theme	isotherm	649:656	arg1	models					745:750	the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	673:750	the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	673:750	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	3	44	theme	isotherm	556:563	arg1	experiments					565:575	Adsorption isotherm experiments	545:575	Adsorption isotherm experiments of As and Pb onto the beads	545:603	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	4	45	theme	Langmuir	1008:1015	arg1	analyses					1023:1030	the Langmuir model analyses	1004:1030	the Langmuir model analyses	1004:1030	The maximum adsorption capacities of the SCM beads were 75.7 and 232.8 mmol/kg for As and Pb, respectively, which were 40 and 5.6 times higher than that of SP according to the Langmuir model analyses.
34444552	2	46	theme	stone	289:293	arg1	SP					303:304	SP	303:304	SP	303:304	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	2	46	theme	stone	289:293	arg1	Mag					338:340	Mag	338:340	Mag	338:340	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	2	46	theme	stone	289:293	arg1	powder					295:300	stone powder	289:300	stone powder (SP)	289:305	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	5	47	theme	coefficient	1083:1093	arg1	values					1100:1105	the highest determinant coefficient (R2) values	1059:1105	the highest determinant coefficient (R2) values for both As and Pb adsorption	1059:1135	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	2	48	from	samples	536:542	arg1	Pb					496:497	Pb	496:497	Pb	496:497	In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples.
34444552	3	49	theme	dual	730:733	arg1	DM					741:742	DM	741:742	DM	741:742	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	3	49	theme	dual	730:733	arg1	mode					735:738	dual mode	730:738	dual mode (DM)	730:743	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	4	50	dep	40	951:952	arg1	higher					968:973	higher	968:973	higher	968:973	The maximum adsorption capacities of the SCM beads were 75.7 and 232.8 mmol/kg for As and Pb, respectively, which were 40 and 5.6 times higher than that of SP according to the Langmuir model analyses.
34444552	5	51	contain	had	1164:1166	arg2	sites					1192:1196	heterogenous adsorption sites	1168:1196	heterogenous adsorption sites	1168:1196	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	5	51	contain	had	1164:1166	arg1	beads					1158:1162	the beads	1154:1162	the beads	1154:1162	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	1	52	from	Arsenic	91:97	arg1	groundwater					135:145	groundwater	135:145	groundwater	135:145	Arsenic (As) and lead (Pb) contamination in groundwater is a serious problem in countries that use groundwater as drinking water.
34444552	0	53	theme	Composite	74:82	arg1	Beads					84:88	Stone Powder/Chitosan/Maghemite Composite Beads	42:88	Stone Powder/Chitosan/Maghemite Composite Beads	42:88	Adsorptive Removal of Arsenic and Lead by Stone Powder/Chitosan/Maghemite Composite Beads.
34444552	3	54	theme	Adsorption	545:554	arg1	experiments					565:575	Adsorption isotherm experiments	545:575	Adsorption isotherm experiments of As and Pb onto the beads	545:603	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34444552	1	55	from	problem	160:166	arg1	countries					171:179	countries	171:179	countries that use groundwater as drinking water	171:218	Arsenic (As) and lead (Pb) contamination in groundwater is a serious problem in countries that use groundwater as drinking water.
34444552	5	56	theme	DM	1046:1047	arg1	model					1049:1053	the DM model	1042:1053	the DM model	1042:1053	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	0	57	theme	Powder/Chitosan/Maghemite	48:72	arg1	Beads					84:88	Stone Powder/Chitosan/Maghemite Composite Beads	42:88	Stone Powder/Chitosan/Maghemite Composite Beads	42:88	Adsorptive Removal of Arsenic and Lead by Stone Powder/Chitosan/Maghemite Composite Beads.
34444552	5	58	contain	had	1055:1057	arg2	values					1100:1105	the highest determinant coefficient (R2) values	1059:1105	the highest determinant coefficient (R2) values for both As and Pb adsorption	1059:1135	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	5	58	contain	had	1055:1057	arg1	model					1049:1053	the DM model	1042:1053	the DM model	1042:1053	However, the DM model had the highest determinant coefficient (R2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities.
34444552	3	59	theme	Langmuir	677:684	arg1	models					745:750	the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	673:750	the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models	673:750	Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics.
34087770	8	0	theme	NPs	1437:1439	arg1	surface					1441:1447	Cs NPs surface	1434:1447	Cs NPs surface	1434:1447	The SOF released from Cs NPs surface was documented at 0.09 mg after 24 h, while PVA NPs reported at 0.7 mg at the same time and the release efficiency is 56.5 and 73% for Cs@SOF and PVP@SOF, respectively.
34087770	5	1	theme	@	1111:1111	arg1	SOF					1112:1114	Cs@SOF	1109:1114	Cs@SOF	1109:1114	Also, the value of KSV was documented at 0.0014 and 7.16 min-1 for Cs@SOF and PVA@SOF hybrid nanocomposite.
34087770	9	2	theme	clinical	1773:1780	arg1	trials					1782:1787	the clinical trials	1769:1787	the clinical trials	1769:1787	From the results, we suggest Cs/SOF and PVA/SOF hybrid nanocomposites have spectroscopic results that make them promising candidate drugs, but need to the clinical trials.
34087770	0	3	with	drug	74:77	arg1	nanoparticles					98:110	bio-polymeric nanoparticles	84:110	bio-polymeric nanoparticles	84:110	Spectroscopic study of self-assembly of anti-hepatitis C virus sofosbuvir drug with bio-polymeric nanoparticles for improving the drug release effect.
34087770	2	4	theme	UV-Vis	714:719	arg1	techniques					752:761	the UV-Vis, and fluorescence spectroscopy techniques	710:761	the UV-Vis, and fluorescence spectroscopy techniques	710:761	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface has been detected by the UV-Vis, and fluorescence spectroscopy techniques.
34087770	1	5	theme	SOF	185:187	arg1	virus					207:211	Sofosbuvir drug (SOF) anti-hepatitis C virus	168:211	Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites	168:358	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	5	theme	SOF	185:187	arg1	HCV					214:216	HCV	214:216	HCV	214:216	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	6	theme	anti-hepatitis	190:203	arg1	virus					207:211	Sofosbuvir drug (SOF) anti-hepatitis C virus	168:211	Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites	168:358	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	6	theme	anti-hepatitis	190:203	arg1	HCV					214:216	HCV	214:216	HCV	214:216	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	2	7	theme	spectroscopy	739:750	arg1	techniques					752:761	the UV-Vis, and fluorescence spectroscopy techniques	710:761	the UV-Vis, and fluorescence spectroscopy techniques	710:761	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface has been detected by the UV-Vis, and fluorescence spectroscopy techniques.
34087770	6	8	theme	biopolymer	1202:1211	arg1	molecules					1218:1226	biopolymer nano molecules	1202:1226	biopolymer nano molecules	1202:1226	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	1	9	theme	virus	207:211	arg1	Self-assembly					151:163	Self-assembly	151:163	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites	151:358	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	3	10	dep	biopolymers	853:863	arg1	NPs					865:867	NPs	865:867	NPs surface at pH 7.4	865:885	The improvement of SOF efficiency was revealed via studying the drug release of SOF from biopolymers NPs surface at pH 7.4, UV-Vis spectra used for the releasing process.
34087770	6	11	from	surface	1191:1197	arg1	0.00812					1249:1255	0.00812	1249:1255	0.00812	1249:1255	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	6	11	from	surface	1191:1197	arg1	k					1174:1174	k	1174:1174	k	1174:1174	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	6	11	from	surface	1191:1197	arg1	rate					1168:1171	The incorporation rate	1150:1171	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules	1150:1226	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	2	12	theme	bio-polymer	665:675	arg1	surface					681:687	the bio-polymer NPs surface	661:687	the bio-polymer NPs surface	661:687	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface has been detected by the UV-Vis, and fluorescence spectroscopy techniques.
34087770	2	13	from	effect	623:628	arg1	surface					681:687	the bio-polymer NPs surface	661:687	the bio-polymer NPs surface	661:687	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface has been detected by the UV-Vis, and fluorescence spectroscopy techniques.
34087770	3	14	from	biopolymers	853:863	arg1	release					833:839	the drug release	824:839	the drug release of SOF from biopolymers NPs surface at pH 7.4, UV-Vis spectra used for the releasing process	824:932	The improvement of SOF efficiency was revealed via studying the drug release of SOF from biopolymers NPs surface at pH 7.4, UV-Vis spectra used for the releasing process.
34087770	9	15	dep	suggest	1639:1645	arg1	need					1761:1764	need	1761:1764	need to the clinical trials	1761:1787	From the results, we suggest Cs/SOF and PVA/SOF hybrid nanocomposites have spectroscopic results that make them promising candidate drugs, but need to the clinical trials.
34087770	9	15	dep	suggest	1639:1645	arg1	have					1688:1691	have	1688:1691	have spectroscopic results that make them promising candidate drugs	1688:1754	From the results, we suggest Cs/SOF and PVA/SOF hybrid nanocomposites have spectroscopic results that make them promising candidate drugs, but need to the clinical trials.
34087770	9	16	theme	promising	1730:1738	arg1	drugs					1750:1754	promising candidate drugs	1730:1754	promising candidate drugs	1730:1754	From the results, we suggest Cs/SOF and PVA/SOF hybrid nanocomposites have spectroscopic results that make them promising candidate drugs, but need to the clinical trials.
34087770	3	17	theme	SOF	844:846	arg1	release					833:839	the drug release	824:839	the drug release of SOF from biopolymers NPs surface at pH 7.4, UV-Vis spectra used for the releasing process	824:932	The improvement of SOF efficiency was revealed via studying the drug release of SOF from biopolymers NPs surface at pH 7.4, UV-Vis spectra used for the releasing process.
34087770	1	18	theme	drug	179:182	arg1	virus					207:211	Sofosbuvir drug (SOF) anti-hepatitis C virus	168:211	Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites	168:358	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	18	theme	drug	179:182	arg1	HCV					214:216	HCV	214:216	HCV	214:216	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	7	19	theme	PVA	1389:1391	arg1	NPs					1393:1395	PVA NPs	1389:1395	PVA NPs	1389:1395	Besides the observed value of (n) was close to the unit 0.74 and 0.86 for Cs and PVA NPs, respectively.
34087770	1	20	theme	X-ray	445:449	arg1	EDX					465:467	EDX	465:467	EDX	465:467	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	20	theme	X-ray	445:449	arg1	spectroscopy					451:462	Energy-dispersive X-ray spectroscopy	427:462	Energy-dispersive X-ray spectroscopy (EDX)	427:468	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	3	21	theme	SOF	783:785	arg1	efficiency					787:796	SOF efficiency	783:796	SOF efficiency	783:796	The improvement of SOF efficiency was revealed via studying the drug release of SOF from biopolymers NPs surface at pH 7.4, UV-Vis spectra used for the releasing process.
34087770	8	22	attach	released	1420:1427	arg1	surface					1441:1447	Cs NPs surface	1434:1447	Cs NPs surface	1434:1447	The SOF released from Cs NPs surface was documented at 0.09 mg after 24 h, while PVA NPs reported at 0.7 mg at the same time and the release efficiency is 56.5 and 73% for Cs@SOF and PVP@SOF, respectively.
34087770	8	22	attach	released	1420:1427	arg2	SOF					1416:1418	The SOF	1412:1418	The SOF released from Cs NPs surface	1412:1447	The SOF released from Cs NPs surface was documented at 0.09 mg after 24 h, while PVA NPs reported at 0.7 mg at the same time and the release efficiency is 56.5 and 73% for Cs@SOF and PVP@SOF, respectively.
34087770	2	23	theme	Sofosbuvir	612:621	arg1	effect					623:628	the Sofosbuvir effect	608:628	the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface	608:687	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface has been detected by the UV-Vis, and fluorescence spectroscopy techniques.
34087770	6	24	theme	molecules	1218:1226	arg1	surface					1191:1197	the surface	1187:1197	the surface of biopolymer nano molecules	1187:1226	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	1	25	theme	novel	343:347	arg1	nanoparticles					269:281	chitosan nanoparticles	260:281	chitosan nanoparticles (Cs NPs)	260:290	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	25	theme	novel	343:347	arg1	composites					349:358	the novel composites	339:358	the novel composites	339:358	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	0	26	theme	anti-hepatitis	40:53	arg1	virus					57:61	anti-hepatitis C virus	40:61	anti-hepatitis C virus	40:61	Spectroscopic study of self-assembly of anti-hepatitis C virus sofosbuvir drug with bio-polymeric nanoparticles for improving the drug release effect.
34087770	2	27	theme	loading	645:651	arg1	drug					653:656	loading drug	645:656	loading drug	645:656	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface has been detected by the UV-Vis, and fluorescence spectroscopy techniques.
34087770	0	28	theme	Spectroscopic	0:12	arg1	study					14:18	Spectroscopic study	0:18	Spectroscopic study of self-assembly of anti-hepatitis C virus	0:61	Spectroscopic study of self-assembly of anti-hepatitis C virus sofosbuvir drug with bio-polymeric nanoparticles for improving the drug release effect.
34087770	8	29	theme	@	1598:1598	arg1	SOF					1599:1601	PVP@SOF	1595:1601	PVP@SOF	1595:1601	The SOF released from Cs NPs surface was documented at 0.09 mg after 24 h, while PVA NPs reported at 0.7 mg at the same time and the release efficiency is 56.5 and 73% for Cs@SOF and PVP@SOF, respectively.
34087770	8	30	dep	NPs	1497:1499	arg1	reported					1501:1508	reported	1501:1508	NPs reported at 0.7 mg at the same time	1497:1535	The SOF released from Cs NPs surface was documented at 0.09 mg after 24 h, while PVA NPs reported at 0.7 mg at the same time and the release efficiency is 56.5 and 73% for Cs@SOF and PVP@SOF, respectively.
34087770	1	31	theme	Fourier	549:555	arg1	FT-IR					581:585	FT-IR	581:585	FT-IR	581:585	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	31	theme	Fourier	549:555	arg1	Infrared					571:578	Fourier Transmittance Infrared	549:578	Fourier Transmittance Infrared (FT-IR)	549:586	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	4	32	theme	constant	947:954	arg1	value					961:965	The binding constant (Kb) value	935:965	The binding constant (Kb) value	935:965	The binding constant (Kb) value was reported at 0.000055 and 0.3613 min-1 for Cs and PVA NPs respectively.
34087770	6	33	from	SOF	1180:1182	arg1	surface					1191:1197	the surface	1187:1197	the surface of biopolymer nano molecules	1187:1226	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	1	34	with	virus	207:211	arg1	nanoparticles					238:250	bio-polymeric nanoparticles	224:250	bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites	224:358	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	34	with	virus	207:211	arg1	nanoparticles					314:326	polyvinyl alcohol nanoparticles	296:326	polyvinyl alcohol nanoparticles	296:326	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	34	with	virus	207:211	arg1	nanoparticles					269:281	chitosan nanoparticles	260:281	chitosan nanoparticles (Cs NPs)	260:290	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	5	35	theme	KSV	1061:1063	arg1	value					1052:1056	the value	1048:1056	the value of KSV	1048:1063	Also, the value of KSV was documented at 0.0014 and 7.16 min-1 for Cs@SOF and PVA@SOF hybrid nanocomposite.
34087770	1	36	theme	electron	480:487	arg1	microscopy					489:498	Scanning electron microscopy	471:498	Scanning electron microscopy (SEM)	471:504	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	36	theme	electron	480:487	arg1	SEM					501:503	SEM	501:503	SEM	501:503	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	0	37	theme	C	55:55	arg1	virus					57:61	anti-hepatitis C virus	40:61	anti-hepatitis C virus	40:61	Spectroscopic study of self-assembly of anti-hepatitis C virus sofosbuvir drug with bio-polymeric nanoparticles for improving the drug release effect.
34087770	1	38	theme	alcohol	306:312	arg1	nanoparticles					314:326	polyvinyl alcohol nanoparticles	296:326	polyvinyl alcohol nanoparticles	296:326	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	39	dep	spectrophotometer	518:534	arg1	UV-Vis					537:542	UV-Vis	537:542	UV-Vis	537:542	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	5	40	theme	PVA	1120:1122	arg1	nanocomposite					1135:1147	PVA@SOF hybrid nanocomposite	1120:1147	PVA@SOF hybrid nanocomposite	1120:1147	Also, the value of KSV was documented at 0.0014 and 7.16 min-1 for Cs@SOF and PVA@SOF hybrid nanocomposite.
34087770	4	41	theme	PVA	1020:1022	arg1	NPs					1024:1026	PVA NPs	1020:1026	PVA NPs	1020:1026	The binding constant (Kb) value was reported at 0.000055 and 0.3613 min-1 for Cs and PVA NPs respectively.
34087770	5	42	theme	SOF	1124:1126	arg1	nanocomposite					1135:1147	PVA@SOF hybrid nanocomposite	1120:1147	PVA@SOF hybrid nanocomposite	1120:1147	Also, the value of KSV was documented at 0.0014 and 7.16 min-1 for Cs@SOF and PVA@SOF hybrid nanocomposite.
34087770	7	43	theme	n	1339:1339	arg1	value					1329:1333	the observed value	1316:1333	the observed value of (n)	1316:1340	Besides the observed value of (n) was close to the unit 0.74 and 0.86 for Cs and PVA NPs, respectively.
34087770	7	43	theme	n	1339:1339	arg1	unit					1359:1362	the unit	1355:1362	the unit	1355:1362	Besides the observed value of (n) was close to the unit 0.74 and 0.86 for Cs and PVA NPs, respectively.
34087770	3	44	theme	releasing	916:924	arg1	process					926:932	the releasing process	912:932	the releasing process	912:932	The improvement of SOF efficiency was revealed via studying the drug release of SOF from biopolymers NPs surface at pH 7.4, UV-Vis spectra used for the releasing process.
34087770	1	45	theme	UV-Visible	507:516	arg1	spectrophotometer					518:534	UV-Visible spectrophotometer	507:534	UV-Visible spectrophotometer (UV-Vis)	507:543	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	5	46	theme	Cs	1109:1110	arg1	SOF					1112:1114	Cs@SOF	1109:1114	Cs@SOF	1109:1114	Also, the value of KSV was documented at 0.0014 and 7.16 min-1 for Cs@SOF and PVA@SOF hybrid nanocomposite.
34087770	8	47	theme	Cs	1434:1435	arg1	surface					1441:1447	Cs NPs surface	1434:1447	Cs NPs surface	1434:1447	The SOF released from Cs NPs surface was documented at 0.09 mg after 24 h, while PVA NPs reported at 0.7 mg at the same time and the release efficiency is 56.5 and 73% for Cs@SOF and PVP@SOF, respectively.
34087770	1	48	theme	Energy-dispersive	427:443	arg1	EDX					465:467	EDX	465:467	EDX	465:467	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	48	theme	Energy-dispersive	427:443	arg1	spectroscopy					451:462	Energy-dispersive X-ray spectroscopy	427:462	Energy-dispersive X-ray spectroscopy (EDX)	427:468	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	49	theme	chitosan	260:267	arg1	NPs					287:289	Cs NPs	284:289	Cs NPs	284:289	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	49	theme	chitosan	260:267	arg1	NPs					333:335	PVA NPs	329:335	PVA NPs	329:335	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	49	theme	chitosan	260:267	arg1	composites					349:358	the novel composites	339:358	the novel composites	339:358	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	49	theme	chitosan	260:267	arg1	nanoparticles					269:281	chitosan nanoparticles	260:281	chitosan nanoparticles (Cs NPs)	260:290	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	7	50	theme	observed	1320:1327	arg1	value					1329:1333	the observed value	1316:1333	the observed value of (n)	1316:1340	Besides the observed value of (n) was close to the unit 0.74 and 0.86 for Cs and PVA NPs, respectively.
34087770	7	50	theme	observed	1320:1327	arg1	unit					1359:1362	the unit	1355:1362	the unit	1355:1362	Besides the observed value of (n) was close to the unit 0.74 and 0.86 for Cs and PVA NPs, respectively.
34087770	6	51	theme	incorporation	1154:1166	arg1	0.00812					1249:1255	0.00812	1249:1255	0.00812	1249:1255	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	6	51	theme	incorporation	1154:1166	arg1	k					1174:1174	k	1174:1174	k	1174:1174	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	6	51	theme	incorporation	1154:1166	arg1	rate					1168:1171	The incorporation rate	1150:1171	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules	1150:1226	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	9	52	theme	PVA/SOF	1658:1664	arg1	nanocomposites					1673:1686	PVA/SOF hybrid nanocomposites	1658:1686	PVA/SOF hybrid nanocomposites	1658:1686	From the results, we suggest Cs/SOF and PVA/SOF hybrid nanocomposites have spectroscopic results that make them promising candidate drugs, but need to the clinical trials.
34087770	0	53	theme	release	135:141	arg1	effect					143:148	the drug release effect	126:148	the drug release effect	126:148	Spectroscopic study of self-assembly of anti-hepatitis C virus sofosbuvir drug with bio-polymeric nanoparticles for improving the drug release effect.
34087770	1	54	theme	C	205:205	arg1	virus					207:211	Sofosbuvir drug (SOF) anti-hepatitis C virus	168:211	Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites	168:358	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	54	theme	C	205:205	arg1	HCV					214:216	HCV	214:216	HCV	214:216	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	2	55	theme	fluorescence	726:737	arg1	spectroscopy					739:750	fluorescence spectroscopy	726:750	fluorescence spectroscopy	726:750	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface has been detected by the UV-Vis, and fluorescence spectroscopy techniques.
34087770	2	56	from	surface	681:687	arg1	improvement					593:603	The improvement	589:603	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface	589:687	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface has been detected by the UV-Vis, and fluorescence spectroscopy techniques.
34087770	8	57	theme	same	1527:1530	arg1	time					1532:1535	the same time	1523:1535	the same time	1523:1535	The SOF released from Cs NPs surface was documented at 0.09 mg after 24 h, while PVA NPs reported at 0.7 mg at the same time and the release efficiency is 56.5 and 73% for Cs@SOF and PVP@SOF, respectively.
34087770	2	58	theme	NPs	677:679	arg1	surface					681:687	the bio-polymer NPs surface	661:687	the bio-polymer NPs surface	661:687	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface has been detected by the UV-Vis, and fluorescence spectroscopy techniques.
34087770	6	59	theme	nano	1213:1216	arg1	molecules					1218:1226	biopolymer nano molecules	1202:1226	biopolymer nano molecules	1202:1226	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	6	60	theme	SOF	1180:1182	arg1	0.00812					1249:1255	0.00812	1249:1255	0.00812	1249:1255	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	6	60	theme	SOF	1180:1182	arg1	k					1174:1174	k	1174:1174	k	1174:1174	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	6	60	theme	SOF	1180:1182	arg1	rate					1168:1171	The incorporation rate	1150:1171	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules	1150:1226	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	1	61	theme	different	400:408	arg1	analysis					410:417	different analysis	400:417	different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR)	400:586	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	8	62	theme	release	1545:1551	arg1	%					1578:1578	56.5 and 73%	1567:1578	56.5 and 73% for Cs@SOF	1567:1589	The SOF released from Cs NPs surface was documented at 0.09 mg after 24 h, while PVA NPs reported at 0.7 mg at the same time and the release efficiency is 56.5 and 73% for Cs@SOF and PVP@SOF, respectively.
34087770	8	62	theme	release	1545:1551	arg1	efficiency					1553:1562	the release efficiency	1541:1562	the release efficiency	1541:1562	The SOF released from Cs NPs surface was documented at 0.09 mg after 24 h, while PVA NPs reported at 0.7 mg at the same time and the release efficiency is 56.5 and 73% for Cs@SOF and PVP@SOF, respectively.
34087770	3	63	theme	drug	828:831	arg1	release					833:839	the drug release	824:839	the drug release of SOF from biopolymers NPs surface at pH 7.4, UV-Vis spectra used for the releasing process	824:932	The improvement of SOF efficiency was revealed via studying the drug release of SOF from biopolymers NPs surface at pH 7.4, UV-Vis spectra used for the releasing process.
34087770	9	64	theme	hybrid	1666:1671	arg1	nanocomposites					1673:1686	PVA/SOF hybrid nanocomposites	1658:1686	PVA/SOF hybrid nanocomposites	1658:1686	From the results, we suggest Cs/SOF and PVA/SOF hybrid nanocomposites have spectroscopic results that make them promising candidate drugs, but need to the clinical trials.
34087770	9	65	theme	candidate	1740:1748	arg1	drugs					1750:1754	promising candidate drugs	1730:1754	promising candidate drugs	1730:1754	From the results, we suggest Cs/SOF and PVA/SOF hybrid nanocomposites have spectroscopic results that make them promising candidate drugs, but need to the clinical trials.
34087770	7	66	dep	unit	1359:1362	arg1	0.74					1364:1367	0.74	1364:1367	0.74	1364:1367	Besides the observed value of (n) was close to the unit 0.74 and 0.86 for Cs and PVA NPs, respectively.
34087770	7	66	dep	unit	1359:1362	arg1	0.86					1373:1376	0.86	1373:1376	0.86	1373:1376	Besides the observed value of (n) was close to the unit 0.74 and 0.86 for Cs and PVA NPs, respectively.
34087770	0	67	theme	bio-polymeric	84:96	arg1	nanoparticles					98:110	bio-polymeric nanoparticles	84:110	bio-polymeric nanoparticles	84:110	Spectroscopic study of self-assembly of anti-hepatitis C virus sofosbuvir drug with bio-polymeric nanoparticles for improving the drug release effect.
34087770	1	68	theme	PVA	329:331	arg1	NPs					333:335	PVA NPs	329:335	PVA NPs	329:335	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	68	theme	PVA	329:331	arg1	nanoparticles					269:281	chitosan nanoparticles	260:281	chitosan nanoparticles (Cs NPs)	260:290	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	69	theme	Sofosbuvir	168:177	arg1	virus					207:211	Sofosbuvir drug (SOF) anti-hepatitis C virus	168:211	Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites	168:358	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	69	theme	Sofosbuvir	168:177	arg1	HCV					214:216	HCV	214:216	HCV	214:216	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	0	70	theme	drug	130:133	arg1	effect					143:148	the drug release effect	126:148	the drug release effect	126:148	Spectroscopic study of self-assembly of anti-hepatitis C virus sofosbuvir drug with bio-polymeric nanoparticles for improving the drug release effect.
34087770	8	71	theme	@	1586:1586	arg1	SOF					1587:1589	Cs@SOF	1584:1589	Cs@SOF	1584:1589	The SOF released from Cs NPs surface was documented at 0.09 mg after 24 h, while PVA NPs reported at 0.7 mg at the same time and the release efficiency is 56.5 and 73% for Cs@SOF and PVP@SOF, respectively.
34087770	2	72	theme	effect	623:628	arg1	improvement					593:603	The improvement	589:603	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface	589:687	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface has been detected by the UV-Vis, and fluorescence spectroscopy techniques.
34087770	3	73	theme	efficiency	787:796	arg1	improvement					768:778	The improvement	764:778	The improvement of SOF efficiency	764:796	The improvement of SOF efficiency was revealed via studying the drug release of SOF from biopolymers NPs surface at pH 7.4, UV-Vis spectra used for the releasing process.
34087770	8	74	theme	Cs	1584:1585	arg1	SOF					1587:1589	Cs@SOF	1584:1589	Cs@SOF	1584:1589	The SOF released from Cs NPs surface was documented at 0.09 mg after 24 h, while PVA NPs reported at 0.7 mg at the same time and the release efficiency is 56.5 and 73% for Cs@SOF and PVP@SOF, respectively.
34087770	2	75	theme	drug	653:656	arg1	result					635:640	a result	633:640	a result of loading drug	633:656	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface has been detected by the UV-Vis, and fluorescence spectroscopy techniques.
34087770	5	76	theme	@	1123:1123	arg1	nanocomposite					1135:1147	PVA@SOF hybrid nanocomposite	1120:1147	PVA@SOF hybrid nanocomposite	1120:1147	Also, the value of KSV was documented at 0.0014 and 7.16 min-1 for Cs@SOF and PVA@SOF hybrid nanocomposite.
34087770	0	77	theme	self-assembly	23:35	arg1	study					14:18	Spectroscopic study	0:18	Spectroscopic study of self-assembly of anti-hepatitis C virus	0:61	Spectroscopic study of self-assembly of anti-hepatitis C virus sofosbuvir drug with bio-polymeric nanoparticles for improving the drug release effect.
34087770	1	78	theme	Cs	284:285	arg1	NPs					287:289	Cs NPs	284:289	Cs NPs	284:289	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	78	theme	Cs	284:285	arg1	nanoparticles					269:281	chitosan nanoparticles	260:281	chitosan nanoparticles (Cs NPs)	260:290	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	8	79	theme	PVP	1595:1597	arg1	SOF					1599:1601	PVP@SOF	1595:1601	PVP@SOF	1595:1601	The SOF released from Cs NPs surface was documented at 0.09 mg after 24 h, while PVA NPs reported at 0.7 mg at the same time and the release efficiency is 56.5 and 73% for Cs@SOF and PVP@SOF, respectively.
34087770	3	80	theme	UV-Vis	888:893	arg1	spectra					895:901	UV-Vis spectra	888:901	UV-Vis spectra used for the releasing process	888:932	The improvement of SOF efficiency was revealed via studying the drug release of SOF from biopolymers NPs surface at pH 7.4, UV-Vis spectra used for the releasing process.
34087770	3	80	theme	UV-Vis	888:893	arg1	biopolymers					853:863	biopolymers	853:863	biopolymers NPs surface at pH 7.4	853:885	The improvement of SOF efficiency was revealed via studying the drug release of SOF from biopolymers NPs surface at pH 7.4, UV-Vis spectra used for the releasing process.
34087770	1	81	theme	Transmittance	557:569	arg1	FT-IR					581:585	FT-IR	581:585	FT-IR	581:585	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	81	theme	Transmittance	557:569	arg1	Infrared					571:578	Fourier Transmittance Infrared	549:578	Fourier Transmittance Infrared (FT-IR)	549:586	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	6	82	theme	PVA	1285:1287	arg1	NPs					1289:1291	PVA NPs	1285:1291	PVA NPs	1285:1291	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	4	83	theme	binding	939:945	arg1	Kb					957:958	Kb	957:958	Kb	957:958	The binding constant (Kb) value was reported at 0.000055 and 0.3613 min-1 for Cs and PVA NPs respectively.
34087770	4	83	theme	binding	939:945	arg1	constant					947:954	binding constant	939:954	The binding constant (Kb) value	935:965	The binding constant (Kb) value was reported at 0.000055 and 0.3613 min-1 for Cs and PVA NPs respectively.
34087770	2	84	from	improvement	593:603	arg1	surface					681:687	the bio-polymer NPs surface	661:687	the bio-polymer NPs surface	661:687	The improvement of the Sofosbuvir effect as a result of loading drug on the bio-polymer NPs surface has been detected by the UV-Vis, and fluorescence spectroscopy techniques.
34087770	1	85	theme	bio-polymeric	224:236	arg1	nanoparticles					238:250	bio-polymeric nanoparticles	224:250	bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites	224:358	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	85	theme	bio-polymeric	224:236	arg1	nanoparticles					314:326	polyvinyl alcohol nanoparticles	296:326	polyvinyl alcohol nanoparticles	296:326	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	85	theme	bio-polymeric	224:236	arg1	nanoparticles					269:281	chitosan nanoparticles	260:281	chitosan nanoparticles (Cs NPs)	260:290	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	86	theme	Scanning	471:478	arg1	microscopy					489:498	Scanning electron microscopy	471:498	Scanning electron microscopy (SEM)	471:504	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	1	86	theme	Scanning	471:478	arg1	SEM					501:503	SEM	501:503	SEM	501:503	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	0	87	theme	virus	57:61	arg1	self-assembly					23:35	self-assembly	23:35	self-assembly of anti-hepatitis C virus	23:61	Spectroscopic study of self-assembly of anti-hepatitis C virus sofosbuvir drug with bio-polymeric nanoparticles for improving the drug release effect.
34087770	1	88	theme	polyvinyl	296:304	arg1	nanoparticles					314:326	polyvinyl alcohol nanoparticles	296:326	polyvinyl alcohol nanoparticles	296:326	Self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles (Cs NPs) and polyvinyl alcohol nanoparticles (PVA NPs), the novel composites have been characterized successfully by different analysis such as Energy-dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), UV-Visible spectrophotometer (UV-Vis) and Fourier Transmittance Infrared (FT-IR).
34087770	9	89	theme	spectroscopic	1693:1705	arg1	results					1707:1713	spectroscopic results	1693:1713	spectroscopic results that make them promising candidate drugs	1693:1754	From the results, we suggest Cs/SOF and PVA/SOF hybrid nanocomposites have spectroscopic results that make them promising candidate drugs, but need to the clinical trials.
34087770	6	90	from	rate	1168:1171	arg1	surface					1191:1197	the surface	1187:1197	the surface of biopolymer nano molecules	1187:1226	The incorporation rate (k) of SOF on the surface of biopolymer nano molecules was calculated to be 0.00812 and 0.0165 min-1 for Cs and PVA NPs, respectively.
34087770	5	91	theme	hybrid	1128:1133	arg1	nanocomposite					1135:1147	PVA@SOF hybrid nanocomposite	1120:1147	PVA@SOF hybrid nanocomposite	1120:1147	Also, the value of KSV was documented at 0.0014 and 7.16 min-1 for Cs@SOF and PVA@SOF hybrid nanocomposite.
34071486	13	0	from	improvement	2614:2624	arg1	function					2635:2642	bowel function	2629:2642	bowel function such as defecation frequency	2629:2671	We conclude that feeding fermented B. rapa L. may be responsible for the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency.
34071486	6	1	theme	bacterial	1085:1093	arg1	composition					1105:1115	The fecal bacterial community composition	1075:1115	The fecal bacterial community composition of the volunteers	1075:1133	The fecal bacterial community composition of the volunteers was characterized using terminal-restriction fragment length polymorphism patterning followed by clustering analysis.
34071486	11	2	theme	cytokine	1908:1915	arg1	production					1917:1926	The cytokine production	1904:1926	The cytokine production of spleen cells	1904:1942	The cytokine production of spleen cells significantly increased due to feeding fermented B. rapa L. to the mice.
34071486	12	3	theme	in	2036:2037	arg1	trial					2044:2048	This supplementary in vivo trial	2017:2048	This supplementary in vivo trial	2017:2048	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	3	4	theme	B.	586:587	arg1	rapa					589:592	fermented B. rapa L.	576:595	fermented B. rapa L.	576:595	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	4	5	theme	subjects	879:886	arg1	number					869:874	the number	865:874	the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption	865:974	The pilot intervention study was conducted for healthy volunteers aged 40-64 years under the hypothesis that the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption may be limited.
34071486	6	6	theme	polymorphism	1196:1207	arg1	patterning					1209:1218	terminal-restriction fragment length polymorphism patterning	1159:1218	terminal-restriction fragment length polymorphism patterning followed by clustering analysis	1159:1250	The fecal bacterial community composition of the volunteers was characterized using terminal-restriction fragment length polymorphism patterning followed by clustering analysis.
34071486	12	7	theme	compositional	2162:2174	arg1	change					2176:2181	the compositional change	2158:2181	the compositional change complying with that of dietary fiber	2158:2218	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	13	8	theme	bowel	2629:2633	arg1	function					2635:2642	bowel function	2629:2642	bowel function such as defecation frequency	2629:2671	We conclude that feeding fermented B. rapa L. may be responsible for the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency.
34071486	7	9	dep	freeze-dried	1410:1421	arg1	fermented					1424:1432	fermented	1424:1432	fermented	1424:1432	To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks.
34071486	10	10	from	increase	1766:1773	arg1	post-ingestion					1888:1901	one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion	1792:1901	one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion	1792:1901	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	6	11	theme	fragment	1180:1187	arg1	polymorphism					1196:1207	terminal-restriction fragment length polymorphism	1159:1207	terminal-restriction fragment length polymorphism patterning followed by clustering analysis	1159:1250	The fecal bacterial community composition of the volunteers was characterized using terminal-restriction fragment length polymorphism patterning followed by clustering analysis.
34071486	13	12	theme	butyrate-producing	2557:2574	arg1	bacteria					2576:2583	butyrate-producing bacteria	2557:2583	butyrate-producing bacteria	2557:2583	We conclude that feeding fermented B. rapa L. may be responsible for the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency.
34071486	3	13	theme	immune	600:605	arg1	function					607:614	immune function	600:614	immune function	600:614	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	1	14	theme	rapa	214:217	arg1	extract					222:228	Brassica rapa L. extract	205:228	Brassica rapa L. extract	205:228	Our previous studies have elucidated that oral administration of Brassica rapa L. extract, known as Nozawana in Japan, alters immune responses and gut microbiota composition, increasing the numbers of butyrate-producing bacteria.
34071486	4	15	theme	rapa	956:959	arg1	consumption					964:974	fermented B. rapa L. consumption	943:974	fermented B. rapa L. consumption	943:974	The pilot intervention study was conducted for healthy volunteers aged 40-64 years under the hypothesis that the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption may be limited.
34071486	7	16	theme	B.	1434:1435	arg1	L.					1442:1443	freeze-dried, fermented B. rapa L.	1410:1443	freeze-dried, fermented B. rapa L.	1410:1443	To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks.
34071486	12	17	from	increase	2241:2248	arg1	amount					2364:2369	daily defecation amount	2347:2369	daily defecation amount	2347:2369	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	12	17	from	increase	2241:2248	arg1	family					2319:2324	the Ruminococcaceae family	2299:2324	the Ruminococcaceae family	2299:2324	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	1	18	theme	extract	222:228	arg1	administration					187:200	oral administration	182:200	oral administration	182:200	Our previous studies have elucidated that oral administration of Brassica rapa L. extract, known as Nozawana in Japan, alters immune responses and gut microbiota composition, increasing the numbers of butyrate-producing bacteria.
34071486	8	19	theme	fecal	1462:1466	arg1	composition					1488:1498	The fecal bacterial community composition	1458:1498	The fecal bacterial community composition of the volunteers before the intervention	1458:1540	The fecal bacterial community composition of the volunteers before the intervention was divided into three clades.
34071486	11	20	theme	cells	1938:1942	arg1	production					1917:1926	The cytokine production	1904:1926	The cytokine production of spleen cells	1904:1942	The cytokine production of spleen cells significantly increased due to feeding fermented B. rapa L. to the mice.
34071486	3	21	theme	bacterial	631:639	arg1	structure					651:659	intestinal bacterial community structure	620:659	intestinal bacterial community structure	620:659	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	8	22	theme	community	1478:1486	arg1	composition					1488:1498	The fecal bacterial community composition	1458:1498	The fecal bacterial community composition of the volunteers before the intervention	1458:1540	The fecal bacterial community composition of the volunteers before the intervention was divided into three clades.
34071486	13	23	theme	observed	2478:2485	arg1	modulation					2487:2496	the observed modulation	2474:2496	the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency	2474:2671	We conclude that feeding fermented B. rapa L. may be responsible for the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency.
34071486	10	24	theme	high	1832:1835	arg1	occupation					1837:1846	high occupation	1832:1846	high occupation of Clostridium at clusters	1832:1873	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	4	25	theme	fermented	943:951	arg1	consumption					964:974	fermented B. rapa L. consumption	943:974	fermented B. rapa L. consumption	943:974	The pilot intervention study was conducted for healthy volunteers aged 40-64 years under the hypothesis that the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption may be limited.
34071486	7	26	theme	healthy	1392:1398	arg1	mice					1400:1403	healthy mice	1392:1403	healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks	1392:1455	To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks.
34071486	4	27	theme	pilot	760:764	arg1	study					779:783	The pilot intervention study	756:783	The pilot intervention study	756:783	The pilot intervention study was conducted for healthy volunteers aged 40-64 years under the hypothesis that the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption may be limited.
34071486	1	28	from	Nozawana	240:247	arg1	Japan					252:256	Japan	252:256	Japan	252:256	Our previous studies have elucidated that oral administration of Brassica rapa L. extract, known as Nozawana in Japan, alters immune responses and gut microbiota composition, increasing the numbers of butyrate-producing bacteria.
34071486	10	29	theme	low	1805:1807	arg1	IV					1875:1876	low to zero Prevotella and high occupation of Clostridium at clusters IV	1805:1876	low to zero Prevotella and high occupation of Clostridium at clusters IV	1805:1876	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	12	30	theme	ingestion	2126:2134	arg1	effects					2115:2121	the effects	2111:2121	the effects of ingestion of the material	2111:2150	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	8	31	theme	volunteers	1507:1516	arg1	composition					1488:1498	The fecal bacterial community composition	1458:1498	The fecal bacterial community composition of the volunteers before the intervention	1458:1540	The fecal bacterial community composition of the volunteers before the intervention was divided into three clades.
34071486	6	32	theme	clustering	1232:1241	arg1	analysis					1243:1250	clustering analysis	1232:1250	clustering analysis	1232:1250	The fecal bacterial community composition of the volunteers was characterized using terminal-restriction fragment length polymorphism patterning followed by clustering analysis.
34071486	10	33	dep	cluster	1796:1802	arg1	XIVa					1882:1885	XIVa	1882:1885	XIVa	1882:1885	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	10	33	dep	cluster	1796:1802	arg1	IV					1875:1876	low to zero Prevotella and high occupation of Clostridium at clusters IV	1805:1876	low to zero Prevotella and high occupation of Clostridium at clusters IV	1805:1876	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	7	34	theme	detailed	1269:1276	arg1	changes					1278:1284	the detailed changes	1265:1284	the detailed changes in the immune responses	1265:1308	To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks.
34071486	10	35	theme	at	1863:1864	arg1	clusters					1866:1873	Clostridium at clusters	1851:1873	Clostridium at clusters	1851:1873	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	2	36	theme	extract	521:527	arg1	ingestion					529:537	B rapa L. extract ingestion	511:537	B rapa L. extract ingestion	511:537	Therefore, further investigation would help elucidate the mechanism attributable for the changes and health-promoting effects observed after B rapa L. extract ingestion.
34071486	12	37	theme	Ruminococcaceae	2303:2317	arg1	family					2319:2324	the Ruminococcaceae family	2299:2324	the Ruminococcaceae family	2299:2324	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	7	38	with	mice	1400:1403	arg1	L.					1442:1443	freeze-dried, fermented B. rapa L.	1410:1443	freeze-dried, fermented B. rapa L.	1410:1443	To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks.
34071486	1	39	theme	bacteria	360:367	arg1	numbers					330:336	the numbers	326:336	the numbers of butyrate-producing bacteria	326:367	Our previous studies have elucidated that oral administration of Brassica rapa L. extract, known as Nozawana in Japan, alters immune responses and gut microbiota composition, increasing the numbers of butyrate-producing bacteria.
34071486	1	40	theme	oral	182:185	arg1	administration					187:200	oral administration	182:200	oral administration	182:200	Our previous studies have elucidated that oral administration of Brassica rapa L. extract, known as Nozawana in Japan, alters immune responses and gut microbiota composition, increasing the numbers of butyrate-producing bacteria.
34071486	4	41	theme	healthy	803:809	arg1	volunteers					811:820	healthy volunteers	803:820	healthy volunteers aged 40-64 years	803:837	The pilot intervention study was conducted for healthy volunteers aged 40-64 years under the hypothesis that the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption may be limited.
34071486	0	42	theme	Colonic	101:107	arg1	Structure					129:137	Colonic Bacterial Community Structure	101:137	Colonic Bacterial Community Structure	101:137	Dietary Supplementation with Fermented Brassica rapa L. Stimulates Defecation Accompanying Change in Colonic Bacterial Community Structure.
34071486	4	43	theme	aged	822:825	arg1	volunteers					811:820	healthy volunteers	803:820	healthy volunteers aged 40-64 years	803:837	The pilot intervention study was conducted for healthy volunteers aged 40-64 years under the hypothesis that the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption may be limited.
34071486	0	44	theme	Community	119:127	arg1	Structure					129:137	Colonic Bacterial Community Structure	101:137	Colonic Bacterial Community Structure	101:137	Dietary Supplementation with Fermented Brassica rapa L. Stimulates Defecation Accompanying Change in Colonic Bacterial Community Structure.
34071486	11	45	theme	spleen	1931:1936	arg1	cells					1938:1942	spleen cells	1931:1942	spleen cells	1931:1942	The cytokine production of spleen cells significantly increased due to feeding fermented B. rapa L. to the mice.
34071486	0	46	theme	Dietary	0:6	arg1	Supplementation					8:22	Dietary Supplementation	0:22	Dietary Supplementation with Fermented Brassica rapa L.	0:54	Dietary Supplementation with Fermented Brassica rapa L. Stimulates Defecation Accompanying Change in Colonic Bacterial Community Structure.
34071486	13	47	theme	B.	2440:2441	arg1	rapa					2443:2446	feeding fermented B. rapa L.	2422:2449	feeding fermented B. rapa L.	2422:2449	We conclude that feeding fermented B. rapa L. may be responsible for the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency.
34071486	10	48	from	clusters	1866:1873	arg1	Clostridium					1851:1861	Clostridium at clusters	1851:1873	Clostridium at clusters	1851:1873	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	10	48	from	clusters	1866:1873	arg1	at					1863:1864	Clostridium at clusters	1851:1873	Clostridium at clusters	1851:1873	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	7	49	theme	high-throughput	1357:1371	arg1	sequencing					1373:1382	high-throughput sequencing	1357:1382	high-throughput sequencing	1357:1382	To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks.
34071486	10	50	theme	clusters	1866:1873	arg1	Prevotella					1817:1826	zero Prevotella	1812:1826	zero Prevotella	1812:1826	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	10	50	theme	clusters	1866:1873	arg1	occupation					1837:1846	high occupation	1832:1846	high occupation of Clostridium at clusters	1832:1873	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	12	51	theme	genera	2253:2258	arg1	Prevotella					2260:2269	genera Prevotella	2253:2269	genera Prevotella	2253:2269	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	11	52	theme	feeding	1975:1981	arg1	rapa					1996:1999	feeding fermented B. rapa L.	1975:2002	feeding fermented B. rapa L. to the mice	1975:2014	The cytokine production of spleen cells significantly increased due to feeding fermented B. rapa L. to the mice.
34071486	1	53	theme	microbiota	291:300	arg1	composition					302:312	gut microbiota composition	287:312	gut microbiota composition	287:312	Our previous studies have elucidated that oral administration of Brassica rapa L. extract, known as Nozawana in Japan, alters immune responses and gut microbiota composition, increasing the numbers of butyrate-producing bacteria.
34071486	12	54	theme	volunteer	2085:2093	arg1	study					2095:2099	the volunteer study	2081:2099	the volunteer study regarding the effects of ingestion of the material	2081:2150	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	2	55	theme	rapa	513:516	arg1	ingestion					529:537	B rapa L. extract ingestion	511:537	B rapa L. extract ingestion	511:537	Therefore, further investigation would help elucidate the mechanism attributable for the changes and health-promoting effects observed after B rapa L. extract ingestion.
34071486	12	56	dep	in	2036:2037	arg1	vivo					2039:2042	vivo	2039:2042	vivo	2039:2042	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	2	57	theme	attributable	438:449	arg1	mechanism					428:436	the mechanism	424:436	the mechanism attributable for the changes and health-promoting effects observed after B rapa L. extract ingestion	424:537	Therefore, further investigation would help elucidate the mechanism attributable for the changes and health-promoting effects observed after B rapa L. extract ingestion.
34071486	0	58	theme	Brassica	39:46	arg1	L.					53:54	Fermented Brassica rapa L.	29:54	Fermented Brassica rapa L.	29:54	Dietary Supplementation with Fermented Brassica rapa L. Stimulates Defecation Accompanying Change in Colonic Bacterial Community Structure.
34071486	5	59	theme	fermented	1033:1041	arg1	rapa					1046:1049	fermented B. rapa L.	1033:1052	fermented B. rapa L.	1033:1052	In total, 20 volunteers consumed 30 g of fermented B. rapa L. per day for 4 weeks.
34071486	10	60	theme	specific	1757:1764	arg1	increase					1766:1773	a specific increase	1755:1773	a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion	1755:1901	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	5	61	theme	rapa	1046:1049	arg1	g					1028:1028	30 g	1025:1028	30 g of fermented B. rapa L.	1025:1052	In total, 20 volunteers consumed 30 g of fermented B. rapa L. per day for 4 weeks.
34071486	7	62	theme	gut	1318:1320	arg1	composition					1332:1342	the gut bacterial composition	1314:1342	the gut bacterial composition	1314:1342	To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks.
34071486	3	63	theme	healthy	702:708	arg1	volunteers					710:719	healthy volunteers	702:719	healthy volunteers followed by a mouse feeding study	702:753	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	12	64	theme	dietary	2206:2212	arg1	fiber					2214:2218	dietary fiber	2206:2218	dietary fiber	2206:2218	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	11	65	dep	rapa	1996:1999	arg1	L.					2001:2002	feeding fermented B. rapa L.	1975:2002	feeding fermented B. rapa L. to the mice	1975:2014	The cytokine production of spleen cells significantly increased due to feeding fermented B. rapa L. to the mice.
34071486	6	66	theme	community	1095:1103	arg1	composition					1105:1115	The fecal bacterial community composition	1075:1115	The fecal bacterial community composition of the volunteers	1075:1133	The fecal bacterial community composition of the volunteers was characterized using terminal-restriction fragment length polymorphism patterning followed by clustering analysis.
34071486	3	67	theme	feeding	741:747	arg1	study					749:753	a mouse feeding study	733:753	a mouse feeding study	733:753	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	7	68	from	changes	1278:1284	arg1	responses					1300:1308	the immune responses	1289:1308	the immune responses	1289:1308	To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks.
34071486	6	69	theme	fecal	1079:1083	arg1	composition					1105:1115	The fecal bacterial community composition	1075:1115	The fecal bacterial community composition of the volunteers	1075:1133	The fecal bacterial community composition of the volunteers was characterized using terminal-restriction fragment length polymorphism patterning followed by clustering analysis.
34071486	3	70	theme	fermented	576:584	arg1	rapa					589:592	fermented B. rapa L.	576:595	fermented B. rapa L.	576:595	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	1	71	theme	immune	266:271	arg1	responses					273:281	immune responses	266:281	immune responses	266:281	Our previous studies have elucidated that oral administration of Brassica rapa L. extract, known as Nozawana in Japan, alters immune responses and gut microbiota composition, increasing the numbers of butyrate-producing bacteria.
34071486	12	72	theme	supplementary	2022:2034	arg1	trial					2044:2048	This supplementary in vivo trial	2017:2048	This supplementary in vivo trial	2017:2048	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	4	73	theme	gut	913:915	arg1	microbiota					917:926	gut microbiota	913:926	gut microbiota	913:926	The pilot intervention study was conducted for healthy volunteers aged 40-64 years under the hypothesis that the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption may be limited.
34071486	12	74	theme	administration	2389:2402	arg1	weeks					2380:2384	2 weeks	2378:2384	2 weeks of administration	2378:2402	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	13	75	theme	fiber-degrading	2528:2542	arg1	bacteria					2544:2551	fiber-degrading bacteria	2528:2551	fiber-degrading bacteria	2528:2551	We conclude that feeding fermented B. rapa L. may be responsible for the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency.
34071486	10	76	theme	cluster	1796:1802	arg1	post-ingestion					1888:1901	one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion	1792:1901	one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion	1792:1901	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	6	77	theme	length	1189:1194	arg1	polymorphism					1196:1207	terminal-restriction fragment length polymorphism	1159:1207	terminal-restriction fragment length polymorphism patterning followed by clustering analysis	1159:1250	The fecal bacterial community composition of the volunteers was characterized using terminal-restriction fragment length polymorphism patterning followed by clustering analysis.
34071486	5	78	dep	rapa	1046:1049	arg1	L.					1051:1052	L.	1051:1052	L.	1051:1052	In total, 20 volunteers consumed 30 g of fermented B. rapa L. per day for 4 weeks.
34071486	1	79	theme	Brassica	205:212	arg1	extract					222:228	Brassica rapa L. extract	205:228	Brassica rapa L. extract	205:228	Our previous studies have elucidated that oral administration of Brassica rapa L. extract, known as Nozawana in Japan, alters immune responses and gut microbiota composition, increasing the numbers of butyrate-producing bacteria.
34071486	6	80	theme	terminal-restriction	1159:1178	arg1	polymorphism					1196:1207	terminal-restriction fragment length polymorphism	1159:1207	terminal-restriction fragment length polymorphism patterning followed by clustering analysis	1159:1250	The fecal bacterial community composition of the volunteers was characterized using terminal-restriction fragment length polymorphism patterning followed by clustering analysis.
34071486	13	81	theme	gut	2501:2503	arg1	microbiota					2505:2514	gut microbiota	2501:2514	gut microbiota	2501:2514	We conclude that feeding fermented B. rapa L. may be responsible for the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency.
34071486	13	82	theme	feeding	2422:2428	arg1	rapa					2443:2446	feeding fermented B. rapa L.	2422:2449	feeding fermented B. rapa L.	2422:2449	We conclude that feeding fermented B. rapa L. may be responsible for the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency.
34071486	3	83	theme	rapa	589:592	arg1	effects					565:571	the modulation effects	550:571	the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure	550:659	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	1	84	theme	L.	219:220	arg1	extract					222:228	Brassica rapa L. extract	205:228	Brassica rapa L. extract	205:228	Our previous studies have elucidated that oral administration of Brassica rapa L. extract, known as Nozawana in Japan, alters immune responses and gut microbiota composition, increasing the numbers of butyrate-producing bacteria.
34071486	4	85	theme	B.	953:954	arg1	consumption					964:974	fermented B. rapa L. consumption	943:974	fermented B. rapa L. consumption	943:974	The pilot intervention study was conducted for healthy volunteers aged 40-64 years under the hypothesis that the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption may be limited.
34071486	8	86	theme	bacterial	1468:1476	arg1	composition					1488:1498	The fecal bacterial community composition	1458:1498	The fecal bacterial community composition of the volunteers before the intervention	1458:1540	The fecal bacterial community composition of the volunteers before the intervention was divided into three clades.
34071486	7	87	theme	rapa	1437:1440	arg1	L.					1442:1443	freeze-dried, fermented B. rapa L.	1410:1443	freeze-dried, fermented B. rapa L.	1410:1443	To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks.
34071486	12	88	theme	defecation	2353:2362	arg1	amount					2364:2369	daily defecation amount	2347:2369	daily defecation amount	2347:2369	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	6	89	theme	volunteers	1124:1133	arg1	composition					1105:1115	The fecal bacterial community composition	1075:1115	The fecal bacterial community composition of the volunteers	1075:1133	The fecal bacterial community composition of the volunteers was characterized using terminal-restriction fragment length polymorphism patterning followed by clustering analysis.
34071486	3	90	theme	intestinal	620:629	arg1	structure					651:659	intestinal bacterial community structure	620:659	intestinal bacterial community structure	620:659	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	3	91	with	study	691:695	arg1	volunteers					710:719	healthy volunteers	702:719	healthy volunteers followed by a mouse feeding study	702:753	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	4	92	theme	L.	961:962	arg1	consumption					964:974	fermented B. rapa L. consumption	943:974	fermented B. rapa L. consumption	943:974	The pilot intervention study was conducted for healthy volunteers aged 40-64 years under the hypothesis that the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption may be limited.
34071486	12	93	theme	material	2143:2150	arg1	ingestion					2126:2134	ingestion	2126:2134	ingestion of the material	2126:2150	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	4	94	dep	consumption	964:974	arg1	response					931:938	response	931:938	response	931:938	The pilot intervention study was conducted for healthy volunteers aged 40-64 years under the hypothesis that the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption may be limited.
34071486	11	95	theme	B.	1993:1994	arg1	rapa					1996:1999	feeding fermented B. rapa L.	1975:2002	feeding fermented B. rapa L. to the mice	1975:2014	The cytokine production of spleen cells significantly increased due to feeding fermented B. rapa L. to the mice.
34071486	10	96	theme	Prevotella	1778:1787	arg1	increase					1766:1773	a specific increase	1755:1773	a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion	1755:1901	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	7	97	theme	freeze-dried	1410:1421	arg1	L.					1442:1443	freeze-dried, fermented B. rapa L.	1410:1443	freeze-dried, fermented B. rapa L.	1410:1443	To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks.
34071486	1	98	theme	previous	144:151	arg1	studies					153:159	Our previous studies	140:159	Our previous studies	140:159	Our previous studies have elucidated that oral administration of Brassica rapa L. extract, known as Nozawana in Japan, alters immune responses and gut microbiota composition, increasing the numbers of butyrate-producing bacteria.
34071486	13	99	from	modulation	2487:2496	arg1	microbiota					2505:2514	gut microbiota	2501:2514	gut microbiota	2501:2514	We conclude that feeding fermented B. rapa L. may be responsible for the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency.
34071486	12	100	theme	daily	2347:2351	arg1	amount					2364:2369	daily defecation amount	2347:2369	daily defecation amount	2347:2369	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	3	101	theme	community	641:649	arg1	structure					651:659	intestinal bacterial community structure	620:659	intestinal bacterial community structure	620:659	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	3	102	dep	rapa	589:592	arg1	L.					594:595	L.	594:595	L.	594:595	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	13	103	dep	rapa	2443:2446	arg1	L.					2448:2449	feeding fermented B. rapa L.	2422:2449	feeding fermented B. rapa L.	2422:2449	We conclude that feeding fermented B. rapa L. may be responsible for the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency.
34071486	3	104	from	effects	565:571	arg1	structure					651:659	intestinal bacterial community structure	620:659	intestinal bacterial community structure	620:659	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	3	104	from	effects	565:571	arg1	function					607:614	immune function	600:614	immune function	600:614	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	13	105	theme	defecation	2652:2661	arg1	frequency					2663:2671	defecation frequency	2652:2671	defecation frequency	2652:2671	We conclude that feeding fermented B. rapa L. may be responsible for the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency.
34071486	1	106	theme	butyrate-producing	341:358	arg1	bacteria					360:367	butyrate-producing bacteria	341:367	butyrate-producing bacteria	341:367	Our previous studies have elucidated that oral administration of Brassica rapa L. extract, known as Nozawana in Japan, alters immune responses and gut microbiota composition, increasing the numbers of butyrate-producing bacteria.
34071486	2	107	theme	L.	518:519	arg1	ingestion					529:537	B rapa L. extract ingestion	511:537	B rapa L. extract ingestion	511:537	Therefore, further investigation would help elucidate the mechanism attributable for the changes and health-promoting effects observed after B rapa L. extract ingestion.
34071486	0	108	theme	Bacterial	109:117	arg1	Structure					129:137	Colonic Bacterial Community Structure	101:137	Colonic Bacterial Community Structure	101:137	Dietary Supplementation with Fermented Brassica rapa L. Stimulates Defecation Accompanying Change in Colonic Bacterial Community Structure.
34071486	4	109	from	change	903:908	arg1	microbiota					917:926	gut microbiota	913:926	gut microbiota	913:926	The pilot intervention study was conducted for healthy volunteers aged 40-64 years under the hypothesis that the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption may be limited.
34071486	12	110	theme	genera	2289:2294	arg1	increase					2241:2248	the increase	2237:2248	the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family	2237:2324	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	12	110	theme	genera	2289:2294	arg1	increase					2335:2342	the increase	2331:2342	the increase in daily defecation amount during 2 weeks of administration	2331:2402	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	12	111	theme	Prevotella	2260:2269	arg1	increase					2241:2248	the increase	2237:2248	the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family	2237:2324	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	12	111	theme	Prevotella	2260:2269	arg1	increase					2335:2342	the increase	2331:2342	the increase in daily defecation amount during 2 weeks of administration	2331:2402	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	12	112	theme	Lachnospira	2272:2282	arg1	increase					2241:2248	the increase	2237:2248	the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family	2237:2324	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	12	112	theme	Lachnospira	2272:2282	arg1	increase					2335:2342	the increase	2331:2342	the increase in daily defecation amount during 2 weeks of administration	2331:2402	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	13	113	theme	fermented	2430:2438	arg1	rapa					2443:2446	feeding fermented B. rapa L.	2422:2449	feeding fermented B. rapa L.	2422:2449	We conclude that feeding fermented B. rapa L. may be responsible for the observed modulation in gut microbiota to increase fiber-degrading bacteria and butyrate-producing bacteria which may be relevant to the improvement in bowel function such as defecation frequency.
34071486	2	114	theme	health-promoting	471:486	arg1	effects					488:494	health-promoting effects	471:494	health-promoting effects	471:494	Therefore, further investigation would help elucidate the mechanism attributable for the changes and health-promoting effects observed after B rapa L. extract ingestion.
34071486	4	115	theme	intervention	766:777	arg1	study					779:783	The pilot intervention study	756:783	The pilot intervention study	756:783	The pilot intervention study was conducted for healthy volunteers aged 40-64 years under the hypothesis that the number of subjects exhibiting any change in gut microbiota in response to fermented B. rapa L. consumption may be limited.
34071486	0	116	from	Change	91:96	arg1	Structure					129:137	Colonic Bacterial Community Structure	101:137	Colonic Bacterial Community Structure	101:137	Dietary Supplementation with Fermented Brassica rapa L. Stimulates Defecation Accompanying Change in Colonic Bacterial Community Structure.
34071486	0	117	theme	Fermented	29:37	arg1	L.					53:54	Fermented Brassica rapa L.	29:54	Fermented Brassica rapa L.	29:54	Dietary Supplementation with Fermented Brassica rapa L. Stimulates Defecation Accompanying Change in Colonic Bacterial Community Structure.
34071486	1	118	theme	gut	287:289	arg1	composition					302:312	gut microbiota composition	287:312	gut microbiota composition	287:312	Our previous studies have elucidated that oral administration of Brassica rapa L. extract, known as Nozawana in Japan, alters immune responses and gut microbiota composition, increasing the numbers of butyrate-producing bacteria.
34071486	9	119	theme	defecation	1602:1611	arg1	frequency					1613:1621	the defecation frequency	1598:1621	the defecation frequency	1598:1621	Regardless of the clade, the defecation frequency significantly increased during the intervention weeks compared with that before the intervention.
34071486	10	120	theme	Clostridium	1851:1861	arg1	clusters					1866:1873	Clostridium at clusters	1851:1873	Clostridium at clusters	1851:1873	However, this clustering detected a specific increase of Prevotella in one cluster (low to zero Prevotella and high occupation of Clostridium at clusters IV and XIVa) post-ingestion.
34071486	3	121	theme	intervention	678:689	arg1	study					691:695	an intervention study	675:695	an intervention study with healthy volunteers followed by a mouse feeding study	675:753	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	11	122	theme	fermented	1983:1991	arg1	rapa					1996:1999	feeding fermented B. rapa L.	1975:2002	feeding fermented B. rapa L. to the mice	1975:2014	The cytokine production of spleen cells significantly increased due to feeding fermented B. rapa L. to the mice.
34071486	0	123	theme	rapa	48:51	arg1	L.					53:54	Fermented Brassica rapa L.	29:54	Fermented Brassica rapa L.	29:54	Dietary Supplementation with Fermented Brassica rapa L. Stimulates Defecation Accompanying Change in Colonic Bacterial Community Structure.
34071486	7	124	theme	bacterial	1322:1330	arg1	composition					1332:1342	the gut bacterial composition	1314:1342	the gut bacterial composition	1314:1342	To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks.
34071486	2	125	theme	B	511:511	arg1	ingestion					529:537	B rapa L. extract ingestion	511:537	B rapa L. extract ingestion	511:537	Therefore, further investigation would help elucidate the mechanism attributable for the changes and health-promoting effects observed after B rapa L. extract ingestion.
34071486	12	126	from	increase	2335:2342	arg1	amount					2364:2369	daily defecation amount	2347:2369	daily defecation amount	2347:2369	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	12	126	from	increase	2335:2342	arg1	family					2319:2324	the Ruminococcaceae family	2299:2324	the Ruminococcaceae family	2299:2324	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	5	127	theme	B.	1043:1044	arg1	rapa					1046:1049	fermented B. rapa L.	1033:1052	fermented B. rapa L.	1033:1052	In total, 20 volunteers consumed 30 g of fermented B. rapa L. per day for 4 weeks.
34071486	7	128	from	composition	1332:1342	arg1	responses					1300:1308	the immune responses	1289:1308	the immune responses	1289:1308	To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks.
34071486	2	129	theme	further	381:387	arg1	investigation					389:401	further investigation	381:401	further investigation	381:401	Therefore, further investigation would help elucidate the mechanism attributable for the changes and health-promoting effects observed after B rapa L. extract ingestion.
34071486	0	130	with	Supplementation	8:22	arg1	L.					53:54	Fermented Brassica rapa L.	29:54	Fermented Brassica rapa L.	29:54	Dietary Supplementation with Fermented Brassica rapa L. Stimulates Defecation Accompanying Change in Colonic Bacterial Community Structure.
34071486	9	131	theme	intervention	1658:1669	arg1	weeks					1671:1675	the intervention weeks	1654:1675	the intervention weeks	1654:1675	Regardless of the clade, the defecation frequency significantly increased during the intervention weeks compared with that before the intervention.
34071486	7	132	theme	immune	1293:1298	arg1	responses					1300:1308	the immune responses	1289:1308	the immune responses	1289:1308	To evaluate the detailed changes in the immune responses and the gut bacterial composition, assessed by high-throughput sequencing, we fed healthy mice with freeze-dried, fermented B. rapa L. for 2 weeks.
34071486	12	133	theme	comparable	2059:2068	arg1	results					2070:2076	comparable results	2059:2076	comparable results	2059:2076	This supplementary in vivo trial provided comparable results to the volunteer study regarding the effects of ingestion of the material given the compositional change complying with that of dietary fiber, particularly in the increase of genera Prevotella, Lachnospira, and genera in the Ruminococcaceae family, and the increase in daily defecation amount during 2 weeks of administration.
34071486	3	134	theme	mouse	735:739	arg1	study					749:753	a mouse feeding study	733:753	a mouse feeding study	733:753	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
34071486	3	135	theme	modulation	554:563	arg1	effects					565:571	the modulation effects	550:571	the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure	550:659	To reveal the modulation effects of fermented B. rapa L. on immune function and intestinal bacterial community structure, we conducted an intervention study with healthy volunteers followed by a mouse feeding study.
33811968	7	0	theme	thicker	1842:1848	arg1	shell					1858:1862	a thicker leucine shell	1840:1862	a thicker leucine shell around the particle	1840:1882	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	1	1	theme	administered	269:280	arg1	vaccines					282:289	nasally administered vaccines	261:289	nasally administered vaccines	261:289	This study investigates the ability of various shell-forming excipients to preserve the dispersibility of dry powder dosage forms, e.g., nasally administered vaccines, upon exposure to a high-humidity environment.
33811968	7	2	from	rate	1542:1545	arg1	conditions					1512:1521	more challenging conditions	1495:1521	more challenging conditions at a 15 L/min flow rate	1495:1545	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	7	3	theme	more	1495:1498	arg1	conditions					1512:1521	more challenging conditions	1495:1521	more challenging conditions at a 15 L/min flow rate	1495:1545	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	7	4	theme	crystalline	1816:1826	arg1	leucine					1828:1834	crystalline leucine	1816:1834	crystalline leucine	1816:1834	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	3	5	theme	monodisperse	559:570	arg1	drying					578:583	Scaled-up monodisperse spray drying	549:583	Scaled-up monodisperse spray drying	549:583	Scaled-up monodisperse spray drying was used to produce sufficient quantities of uniform-sized particles for powder dispersibility analysis.
33811968	5	6	theme	two-component	915:927	arg1	systems					938:944	Three two-component particle systems	909:944	Three two-component particle systems composed of trehalose/trileucine (97/3 w/w), trehalose/pullulan (70/30 w/w), and trehalose/leucine (70/30 w/w)	909:1055	Three two-component particle systems composed of trehalose/trileucine (97/3 w/w), trehalose/pullulan (70/30 w/w), and trehalose/leucine (70/30 w/w) were first formulated and their dispersibility, characterized as the emitted dose from dry powder inhalers, was then compared with that of trehalose particles.
33811968	7	7	theme	higher	1645:1650	arg1	concentration					1660:1672	a higher leucine concentration	1643:1672	a higher leucine concentration	1643:1672	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	7	8	theme	higher	1789:1794	arg1	coverage					1804:1811	higher surface coverage	1789:1811	higher surface coverage of crystalline leucine and a thicker leucine shell around the particle	1789:1882	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	3	9	used	used	589:592	arg2	drying					578:583	Scaled-up monodisperse spray drying	549:583	Scaled-up monodisperse spray drying	549:583	Scaled-up monodisperse spray drying was used to produce sufficient quantities of uniform-sized particles for powder dispersibility analysis.
33811968	6	10	theme	90	1354:1355	arg1	%					1356:1356	%	1356:1356	%	1356:1356	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	1	11	theme	dry	230:232	arg1	forms					248:252	dry powder dosage forms	230:252	dry powder dosage forms	230:252	This study investigates the ability of various shell-forming excipients to preserve the dispersibility of dry powder dosage forms, e.g., nasally administered vaccines, upon exposure to a high-humidity environment.
33811968	6	12	theme	emitted	1279:1285	arg1	dose					1287:1290	the highest emitted dose	1267:1290	the highest emitted dose (90.3 ± 10%)	1267:1303	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	6	12	theme	emitted	1279:1285	arg1	%					1302:1302	90.3 ± 10%	1293:1302	90.3 ± 10%	1293:1302	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	8	13	theme	shell-forming	1951:1963	arg1	excipient					1965:1973	an appropriate shell-forming excipient	1936:1973	an appropriate shell-forming excipient	1936:1973	The study concludes that leucine may be considered an appropriate shell-forming excipient in the development of dry powder formulations in order to protect the dosage forms against humidity during administration.
33811968	5	14	theme	emitted	1126:1132	arg1	dose					1134:1137	the emitted dose	1122:1137	the emitted dose from dry powder inhalers	1122:1162	Three two-component particle systems composed of trehalose/trileucine (97/3 w/w), trehalose/pullulan (70/30 w/w), and trehalose/leucine (70/30 w/w) were first formulated and their dispersibility, characterized as the emitted dose from dry powder inhalers, was then compared with that of trehalose particles.
33811968	3	15	theme	uniform-sized	630:642	arg1	particles					644:652	uniform-sized particles	630:652	uniform-sized particles	630:652	Scaled-up monodisperse spray drying was used to produce sufficient quantities of uniform-sized particles for powder dispersibility analysis.
33811968	7	16	with	system	1572:1577	arg1	w/w					1626:1628	70/30, 80/20, 90/10 w/w	1606:1628	70/30, 80/20, 90/10 w/w	1606:1628	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	7	16	with	system	1572:1577	arg1	compositions					1592:1603	various compositions	1584:1603	various compositions (70/30, 80/20, 90/10 w/w)	1584:1629	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	1	17	theme	dosage	241:246	arg1	forms					248:252	dry powder dosage forms	230:252	dry powder dosage forms	230:252	This study investigates the ability of various shell-forming excipients to preserve the dispersibility of dry powder dosage forms, e.g., nasally administered vaccines, upon exposure to a high-humidity environment.
33811968	6	18	theme	flow	1319:1322	arg1	rate					1324:1327	a 60 L/min flow rate	1308:1327	a 60 L/min flow rate	1308:1327	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	3	19	theme	dispersibility	665:678	arg1	analysis					680:687	powder dispersibility analysis	658:687	powder dispersibility analysis	658:687	Scaled-up monodisperse spray drying was used to produce sufficient quantities of uniform-sized particles for powder dispersibility analysis.
33811968	6	20	theme	30	1244:1245	arg1	%					1246:1246	%	1246:1246	%	1246:1246	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	8	21	theme	dry	1997:1999	arg1	formulations					2008:2019	dry powder formulations	1997:2019	dry powder formulations	1997:2019	The study concludes that leucine may be considered an appropriate shell-forming excipient in the development of dry powder formulations in order to protect the dosage forms against humidity during administration.
33811968	1	22	theme	various	163:169	arg1	excipients					185:194	various shell-forming excipients	163:194	various shell-forming excipients	163:194	This study investigates the ability of various shell-forming excipients to preserve the dispersibility of dry powder dosage forms, e.g., nasally administered vaccines, upon exposure to a high-humidity environment.
33811968	7	23	theme	higher	1743:1748	arg1	dispersibility					1757:1770	higher powder dispersibility	1743:1770	higher powder dispersibility	1743:1770	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	4	24	theme	powders	742:748	arg1	crystallinity					705:717	crystallinity	705:717	crystallinity	705:717	Particle size, crystallinity, and morphology of the powders before and after exposure to moisture were characterized by an aerodynamic particle sizer, Raman spectroscopy, and scanning electron microscopy, respectively.
33811968	4	24	theme	powders	742:748	arg1	morphology					724:733	morphology	724:733	morphology	724:733	Particle size, crystallinity, and morphology of the powders before and after exposure to moisture were characterized by an aerodynamic particle sizer, Raman spectroscopy, and scanning electron microscopy, respectively.
33811968	4	24	theme	powders	742:748	arg1	size					699:702	Particle size	690:702	Particle size	690:702	Particle size, crystallinity, and morphology of the powders before and after exposure to moisture were characterized by an aerodynamic particle sizer, Raman spectroscopy, and scanning electron microscopy, respectively.
33811968	8	25	theme	formulations	2008:2019	arg1	development					1982:1992	the development	1978:1992	the development of dry powder formulations	1978:2019	The study concludes that leucine may be considered an appropriate shell-forming excipient in the development of dry powder formulations in order to protect the dosage forms against humidity during administration.
33811968	1	26	theme	excipients	185:194	arg1	ability					152:158	the ability	148:158	the ability of various shell-forming excipients to preserve the dispersibility of dry powder dosage forms, e.g., nasally administered vaccines, upon exposure to a high-humidity environment	148:335	This study investigates the ability of various shell-forming excipients to preserve the dispersibility of dry powder dosage forms, e.g., nasally administered vaccines, upon exposure to a high-humidity environment.
33811968	0	27	theme	high-humidity	97:109	arg1	environment					111:121	a high-humidity environment	95:121	a high-humidity environment	95:121	Leucine enhances the dispersibility of trehalose-containing spray-dried powders on exposure to a high-humidity environment.
33811968	2	28	theme	trehalose	528:536	arg1	particles					538:546	pure trehalose particles	523:546	pure trehalose particles	523:546	Trehalose combinations using leucine, pullulan, or trileucine were selected as the candidate excipient systems, and the powder dispersibility of these systems was compared with that of pure trehalose particles.
33811968	4	29	theme	particle	825:832	arg1	spectroscopy					847:858	an aerodynamic particle sizer, Raman spectroscopy	810:858	spectroscopy	847:858	Particle size, crystallinity, and morphology of the powders before and after exposure to moisture were characterized by an aerodynamic particle sizer, Raman spectroscopy, and scanning electron microscopy, respectively.
33811968	5	30	theme	powder	1148:1153	arg1	inhalers					1155:1162	dry powder inhalers	1144:1162	dry powder inhalers	1144:1162	Three two-component particle systems composed of trehalose/trileucine (97/3 w/w), trehalose/pullulan (70/30 w/w), and trehalose/leucine (70/30 w/w) were first formulated and their dispersibility, characterized as the emitted dose from dry powder inhalers, was then compared with that of trehalose particles.
33811968	7	31	theme	better	1693:1698	arg1	protection					1700:1709	better protection	1693:1709	better protection against moisture	1693:1726	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	8	32	theme	dosage	2045:2050	arg1	forms					2052:2056	the dosage forms	2041:2056	the dosage forms	2041:2056	The study concludes that leucine may be considered an appropriate shell-forming excipient in the development of dry powder formulations in order to protect the dosage forms against humidity during administration.
33811968	7	33	theme	leucine	1652:1658	arg1	concentration					1660:1672	a higher leucine concentration	1643:1672	a higher leucine concentration	1643:1672	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	2	34	theme	excipient	431:439	arg1	combinations					348:359	Trehalose combinations	338:359	Trehalose combinations using leucine, pullulan, or trileucine	338:398	Trehalose combinations using leucine, pullulan, or trileucine were selected as the candidate excipient systems, and the powder dispersibility of these systems was compared with that of pure trehalose particles.
33811968	2	34	theme	excipient	431:439	arg1	systems					441:447	the candidate excipient systems	417:447	the candidate excipient systems	417:447	Trehalose combinations using leucine, pullulan, or trileucine were selected as the candidate excipient systems, and the powder dispersibility of these systems was compared with that of pure trehalose particles.
33811968	1	35	theme	high-humidity	311:323	arg1	environment					325:335	a high-humidity environment	309:335	a high-humidity environment	309:335	This study investigates the ability of various shell-forming excipients to preserve the dispersibility of dry powder dosage forms, e.g., nasally administered vaccines, upon exposure to a high-humidity environment.
33811968	6	36	theme	superior	1384:1391	arg1	protection					1393:1402	its superior protection	1380:1402	its superior protection against exposure to humidity	1380:1431	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	4	37	theme	electron	874:881	arg1	microscopy					883:892	scanning electron microscopy	865:892	scanning electron microscopy	865:892	Particle size, crystallinity, and morphology of the powders before and after exposure to moisture were characterized by an aerodynamic particle sizer, Raman spectroscopy, and scanning electron microscopy, respectively.
33811968	0	38	theme	spray-dried	60:70	arg1	powders					72:78	trehalose-containing spray-dried powders	39:78	trehalose-containing spray-dried powders	39:78	Leucine enhances the dispersibility of trehalose-containing spray-dried powders on exposure to a high-humidity environment.
33811968	7	39	theme	15 L/min	1528:1535	arg1	rate					1542:1545	a 15 L/min flow rate	1526:1545	a 15 L/min flow rate	1526:1545	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	1	40	theme	forms	248:252	arg1	dispersibility					212:225	the dispersibility	208:225	the dispersibility of dry powder dosage forms, e.g., nasally administered vaccines,	208:290	This study investigates the ability of various shell-forming excipients to preserve the dispersibility of dry powder dosage forms, e.g., nasally administered vaccines, upon exposure to a high-humidity environment.
33811968	7	41	theme	leucine	1850:1856	arg1	shell					1858:1862	a thicker leucine shell	1840:1862	a thicker leucine shell around the particle	1840:1882	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	7	42	theme	challenging	1500:1510	arg1	conditions					1512:1521	more challenging conditions	1495:1521	more challenging conditions at a 15 L/min flow rate	1495:1545	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	6	43	theme	60 L/min	1310:1317	arg1	rate					1324:1327	a 60 L/min flow rate	1308:1327	a 60 L/min flow rate	1308:1327	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	7	44	theme	leucine	1828:1834	arg1	coverage					1804:1811	higher surface coverage	1789:1811	higher surface coverage of crystalline leucine and a thicker leucine shell around the particle	1789:1882	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	3	45	theme	spray	572:576	arg1	drying					578:583	Scaled-up monodisperse spray drying	549:583	Scaled-up monodisperse spray drying	549:583	Scaled-up monodisperse spray drying was used to produce sufficient quantities of uniform-sized particles for powder dispersibility analysis.
33811968	7	46	theme	Further	1466:1472	arg1	investigations					1474:1487	Further investigations	1466:1487	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w)	1466:1629	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	3	47	theme	Scaled-up	549:557	arg1	drying					578:583	Scaled-up monodisperse spray drying	549:583	Scaled-up monodisperse spray drying	549:583	Scaled-up monodisperse spray drying was used to produce sufficient quantities of uniform-sized particles for powder dispersibility analysis.
33811968	4	48	dep	spectroscopy	847:858	arg1	Raman					841:845	an aerodynamic particle sizer, Raman spectroscopy	810:858	Raman	841:845	Particle size, crystallinity, and morphology of the powders before and after exposure to moisture were characterized by an aerodynamic particle sizer, Raman spectroscopy, and scanning electron microscopy, respectively.
33811968	7	49	theme	surface	1796:1802	arg1	coverage					1804:1811	higher surface coverage	1789:1811	higher surface coverage of crystalline leucine and a thicker leucine shell around the particle	1789:1882	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	2	50	theme	Trehalose	338:346	arg1	combinations					348:359	Trehalose combinations	338:359	Trehalose combinations using leucine, pullulan, or trileucine	338:398	Trehalose combinations using leucine, pullulan, or trileucine were selected as the candidate excipient systems, and the powder dispersibility of these systems was compared with that of pure trehalose particles.
33811968	2	50	theme	Trehalose	338:346	arg1	systems					441:447	the candidate excipient systems	417:447	the candidate excipient systems	417:447	Trehalose combinations using leucine, pullulan, or trileucine were selected as the candidate excipient systems, and the powder dispersibility of these systems was compared with that of pure trehalose particles.
33811968	5	51	theme	particle	929:936	arg1	systems					938:944	Three two-component particle systems	909:944	Three two-component particle systems composed of trehalose/trileucine (97/3 w/w), trehalose/pullulan (70/30 w/w), and trehalose/leucine (70/30 w/w)	909:1055	Three two-component particle systems composed of trehalose/trileucine (97/3 w/w), trehalose/pullulan (70/30 w/w), and trehalose/leucine (70/30 w/w) were first formulated and their dispersibility, characterized as the emitted dose from dry powder inhalers, was then compared with that of trehalose particles.
33811968	6	52	theme	%	1356:1356	arg1	RH					1358:1359	90% RH	1354:1359	90% RH	1354:1359	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	7	53	from	investigations	1474:1487	arg1	system					1572:1577	the trehalose/leucine system	1550:1577	the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w)	1550:1629	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	1	54	theme	powder	234:239	arg1	forms					248:252	dry powder dosage forms	230:252	dry powder dosage forms	230:252	This study investigates the ability of various shell-forming excipients to preserve the dispersibility of dry powder dosage forms, e.g., nasally administered vaccines, upon exposure to a high-humidity environment.
33811968	6	55	theme	highest	1271:1277	arg1	dose					1287:1290	the highest emitted dose	1267:1290	the highest emitted dose (90.3 ± 10%)	1267:1303	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	6	55	theme	highest	1271:1277	arg1	%					1302:1302	90.3 ± 10%	1293:1302	90.3 ± 10%	1293:1302	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	4	56	theme	Particle	690:697	arg1	size					699:702	Particle size	690:702	Particle size	690:702	Particle size, crystallinity, and morphology of the powders before and after exposure to moisture were characterized by an aerodynamic particle sizer, Raman spectroscopy, and scanning electron microscopy, respectively.
33811968	6	57	theme	60 min	1335:1340	arg1	exposure					1342:1349	60 min exposure	1335:1349	60 min exposure to 90% RH	1335:1359	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	3	58	theme	sufficient	605:614	arg1	quantities					616:625	sufficient quantities	605:625	sufficient quantities of uniform-sized particles for powder dispersibility analysis	605:687	Scaled-up monodisperse spray drying was used to produce sufficient quantities of uniform-sized particles for powder dispersibility analysis.
33811968	5	59	from	inhalers	1155:1162	arg1	dose					1134:1137	the emitted dose	1122:1137	the emitted dose from dry powder inhalers	1122:1162	Three two-component particle systems composed of trehalose/trileucine (97/3 w/w), trehalose/pullulan (70/30 w/w), and trehalose/leucine (70/30 w/w) were first formulated and their dispersibility, characterized as the emitted dose from dry powder inhalers, was then compared with that of trehalose particles.
33811968	8	60	theme	appropriate	1939:1949	arg1	excipient					1965:1973	an appropriate shell-forming excipient	1936:1973	an appropriate shell-forming excipient	1936:1973	The study concludes that leucine may be considered an appropriate shell-forming excipient in the development of dry powder formulations in order to protect the dosage forms against humidity during administration.
33811968	1	61	dep	vaccines	282:289	arg1	e.g.					255:258	e.g.	255:258	e.g.	255:258	This study investigates the ability of various shell-forming excipients to preserve the dispersibility of dry powder dosage forms, e.g., nasally administered vaccines, upon exposure to a high-humidity environment.
33811968	3	62	theme	powder	658:663	arg1	analysis					680:687	powder dispersibility analysis	658:687	powder dispersibility analysis	658:687	Scaled-up monodisperse spray drying was used to produce sufficient quantities of uniform-sized particles for powder dispersibility analysis.
33811968	6	63	theme	%	1246:1246	arg1	leucine					1248:1254	30% leucine	1244:1254	30% leucine	1244:1254	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	8	64	theme	powder	2001:2006	arg1	formulations					2008:2019	dry powder formulations	1997:2019	dry powder formulations	1997:2019	The study concludes that leucine may be considered an appropriate shell-forming excipient in the development of dry powder formulations in order to protect the dosage forms against humidity during administration.
33811968	3	65	theme	particles	644:652	arg1	quantities					616:625	sufficient quantities	605:625	sufficient quantities of uniform-sized particles for powder dispersibility analysis	605:687	Scaled-up monodisperse spray drying was used to produce sufficient quantities of uniform-sized particles for powder dispersibility analysis.
33811968	0	66	from	dispersibility	21:34	arg1	exposure					83:90	exposure	83:90	exposure to a high-humidity environment	83:121	Leucine enhances the dispersibility of trehalose-containing spray-dried powders on exposure to a high-humidity environment.
33811968	1	67	theme	shell-forming	171:183	arg1	excipients					185:194	various shell-forming excipients	163:194	various shell-forming excipients	163:194	This study investigates the ability of various shell-forming excipients to preserve the dispersibility of dry powder dosage forms, e.g., nasally administered vaccines, upon exposure to a high-humidity environment.
33811968	7	68	theme	powder	1750:1755	arg1	dispersibility					1757:1770	higher powder dispersibility	1743:1770	higher powder dispersibility	1743:1770	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	7	69	theme	various	1584:1590	arg1	w/w					1626:1628	70/30, 80/20, 90/10 w/w	1606:1628	70/30, 80/20, 90/10 w/w	1606:1628	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	7	69	theme	various	1584:1590	arg1	compositions					1592:1603	various compositions	1584:1603	various compositions (70/30, 80/20, 90/10 w/w)	1584:1629	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	5	70	theme	dry	1144:1146	arg1	inhalers					1155:1162	dry powder inhalers	1144:1162	dry powder inhalers	1144:1162	Three two-component particle systems composed of trehalose/trileucine (97/3 w/w), trehalose/pullulan (70/30 w/w), and trehalose/leucine (70/30 w/w) were first formulated and their dispersibility, characterized as the emitted dose from dry powder inhalers, was then compared with that of trehalose particles.
33811968	2	71	theme	pure	523:526	arg1	particles					538:546	pure trehalose particles	523:546	pure trehalose particles	523:546	Trehalose combinations using leucine, pullulan, or trileucine were selected as the candidate excipient systems, and the powder dispersibility of these systems was compared with that of pure trehalose particles.
33811968	4	72	theme	aerodynamic	813:823	arg1	spectroscopy					847:858	an aerodynamic particle sizer, Raman spectroscopy	810:858	spectroscopy	847:858	Particle size, crystallinity, and morphology of the powders before and after exposure to moisture were characterized by an aerodynamic particle sizer, Raman spectroscopy, and scanning electron microscopy, respectively.
33811968	6	73	theme	other	1451:1455	arg1	systems					1457:1463	the other systems	1447:1463	the other systems	1447:1463	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	2	74	theme	powder	458:463	arg1	dispersibility					465:478	the powder dispersibility	454:478	the powder dispersibility of these systems	454:495	Trehalose combinations using leucine, pullulan, or trileucine were selected as the candidate excipient systems, and the powder dispersibility of these systems was compared with that of pure trehalose particles.
33811968	0	75	theme	trehalose-containing	39:58	arg1	powders					72:78	trehalose-containing spray-dried powders	39:78	trehalose-containing spray-dried powders	39:78	Leucine enhances the dispersibility of trehalose-containing spray-dried powders on exposure to a high-humidity environment.
33811968	7	76	theme	trehalose/leucine	1554:1570	arg1	system					1572:1577	the trehalose/leucine system	1550:1577	the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w)	1550:1629	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	2	77	theme	systems	489:495	arg1	dispersibility					465:478	the powder dispersibility	454:478	the powder dispersibility of these systems	454:495	Trehalose combinations using leucine, pullulan, or trileucine were selected as the candidate excipient systems, and the powder dispersibility of these systems was compared with that of pure trehalose particles.
33811968	6	78	contain	containing	1233:1242	arg2	leucine					1248:1254	30% leucine	1244:1254	30% leucine	1244:1254	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	6	78	contain	containing	1233:1242	arg1	formulation					1221:1231	The formulation	1217:1231	The formulation containing 30% leucine	1217:1254	The formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after 60 min exposure to 90% RH and 25 °C, showing its superior protection against exposure to humidity compared with the other systems.
33811968	2	79	theme	candidate	421:429	arg1	combinations					348:359	Trehalose combinations	338:359	Trehalose combinations using leucine, pullulan, or trileucine	338:398	Trehalose combinations using leucine, pullulan, or trileucine were selected as the candidate excipient systems, and the powder dispersibility of these systems was compared with that of pure trehalose particles.
33811968	2	79	theme	candidate	421:429	arg1	systems					441:447	the candidate excipient systems	417:447	the candidate excipient systems	417:447	Trehalose combinations using leucine, pullulan, or trileucine were selected as the candidate excipient systems, and the powder dispersibility of these systems was compared with that of pure trehalose particles.
33811968	0	80	theme	powders	72:78	arg1	dispersibility					21:34	the dispersibility	17:34	the dispersibility of trehalose-containing spray-dried powders on exposure to a high-humidity environment	17:121	Leucine enhances the dispersibility of trehalose-containing spray-dried powders on exposure to a high-humidity environment.
33811968	4	81	theme	scanning	865:872	arg1	microscopy					883:892	scanning electron microscopy	865:892	scanning electron microscopy	865:892	Particle size, crystallinity, and morphology of the powders before and after exposure to moisture were characterized by an aerodynamic particle sizer, Raman spectroscopy, and scanning electron microscopy, respectively.
33811968	5	82	theme	trehalose	1196:1204	arg1	particles					1206:1214	trehalose particles	1196:1214	trehalose particles	1196:1214	Three two-component particle systems composed of trehalose/trileucine (97/3 w/w), trehalose/pullulan (70/30 w/w), and trehalose/leucine (70/30 w/w) were first formulated and their dispersibility, characterized as the emitted dose from dry powder inhalers, was then compared with that of trehalose particles.
33811968	7	83	theme	flow	1537:1540	arg1	rate					1542:1545	a 15 L/min flow rate	1526:1545	a 15 L/min flow rate	1526:1545	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
33811968	4	84	theme	sizer	834:838	arg1	spectroscopy					847:858	an aerodynamic particle sizer, Raman spectroscopy	810:858	spectroscopy	847:858	Particle size, crystallinity, and morphology of the powders before and after exposure to moisture were characterized by an aerodynamic particle sizer, Raman spectroscopy, and scanning electron microscopy, respectively.
33811968	7	85	theme	shell	1858:1862	arg1	coverage					1804:1811	higher surface coverage	1789:1811	higher surface coverage of crystalline leucine and a thicker leucine shell around the particle	1789:1882	Further investigations under more challenging conditions at a 15 L/min flow rate on the trehalose/leucine system with various compositions (70/30, 80/20, 90/10 w/w) showed that a higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility, probably due to higher surface coverage of crystalline leucine and a thicker leucine shell around the particle.
35006786	7	0	dep	adhesion	1123:1130	arg1	the					1119:1121	the	1119:1121	the	1119:1121	In addition, moderate addition of HAP enhanced the adhesion, differentiation, and mineralization of osteoblasts.
35006786	8	1	theme	composite	1198:1206	arg1	membranes					1208:1216	The prepared composite membranes	1185:1216	The prepared composite membranes	1185:1216	The prepared composite membranes were then implanted into a calvarial defect model to evaluate their osteogenic induction effects in vivo.
35006786	10	2	theme	superior	1586:1593	arg1	properties					1606:1615	superior mechanical properties	1586:1615	superior mechanical properties	1586:1615	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	2	3	dep	oxide	307:311	arg1	GO					314:315	GO	314:315	GO	314:315	Graphene oxide (GO) has been widely employed in GBR due to its good mechanical and hydrophilic properties.
35006786	1	4	theme	bone	273:276	arg1	regeneration					278:289	guided bone regeneration	266:289	guided bone regeneration (GBR)	266:295	Two-dimensional materials provide a secluded space for bone formation and preserve the growth of surrounding tissues, thus playing a crucial role in guided bone regeneration (GBR).
35006786	1	4	theme	bone	273:276	arg1	GBR					292:294	GBR	292:294	GBR	292:294	Two-dimensional materials provide a secluded space for bone formation and preserve the growth of surrounding tissues, thus playing a crucial role in guided bone regeneration (GBR).
35006786	10	5	theme	regeneration	1637:1648	arg1	capacity					1650:1657	excellent bone regeneration capacity	1622:1657	excellent bone regeneration capacity	1622:1657	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	7	6	theme	osteoblasts	1172:1182	arg1	differentiation					1133:1147	differentiation	1133:1147	differentiation	1133:1147	In addition, moderate addition of HAP enhanced the adhesion, differentiation, and mineralization of osteoblasts.
35006786	7	6	theme	osteoblasts	1172:1182	arg1	mineralization					1154:1167	mineralization	1154:1167	mineralization	1154:1167	In addition, moderate addition of HAP enhanced the adhesion, differentiation, and mineralization of osteoblasts.
35006786	7	6	theme	osteoblasts	1172:1182	arg1	adhesion					1123:1130	adhesion	1123:1130	adhesion	1123:1130	In addition, moderate addition of HAP enhanced the adhesion, differentiation, and mineralization of osteoblasts.
35006786	10	7	theme	composite	1524:1532	arg1	materials					1673:1681	potential materials	1663:1681	potential materials for application in GBR	1663:1704	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	10	7	theme	composite	1524:1532	arg1	membranes					1534:1542	GO/CS/HAP composite membranes	1514:1542	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity	1514:1657	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	3	8	theme	cell	491:494	arg1	adhesion					496:503	osteogenic cell adhesion	480:503	osteogenic cell adhesion	480:503	A single GO membrane, however, does not provide a friendly environment for osteogenic cell adhesion.
35006786	10	9	theme	bone	1632:1635	arg1	capacity					1650:1657	excellent bone regeneration capacity	1622:1657	excellent bone regeneration capacity	1622:1657	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	10	10	theme	unique	1549:1554	arg1	structures					1574:1583	unique biomimetic porous structures	1549:1583	unique biomimetic porous structures	1549:1583	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	10	11	theme	GO/CS/HAP	1514:1522	arg1	materials					1673:1681	potential materials	1663:1681	potential materials for application in GBR	1663:1704	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	10	11	theme	GO/CS/HAP	1514:1522	arg1	membranes					1534:1542	GO/CS/HAP composite membranes	1514:1542	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity	1514:1657	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	5	12	theme	sufficient	767:776	arg1	biocompatibility					778:793	sufficient biocompatibility	767:793	sufficient biocompatibility	767:793	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	9	13	theme	GO/CS/HAP	1401:1409	arg1	membranes					1421:1429	GO/CS/HAP composite membranes	1401:1429	GO/CS/HAP composite membranes	1401:1429	Microcomputed tomography observation and histological analysis indicate that GO/CS/HAP composite membranes can accelerate bone regeneration without the contribution of endogenous cytokines.
35006786	2	14	theme	Graphene	298:305	arg1	oxide					307:311	Graphene oxide	298:311	Graphene oxide (GO)	298:316	Graphene oxide (GO) has been widely employed in GBR due to its good mechanical and hydrophilic properties.
35006786	9	15	theme	cytokines	1503:1511	arg1	contribution					1476:1487	the contribution	1472:1487	the contribution of endogenous cytokines	1472:1511	Microcomputed tomography observation and histological analysis indicate that GO/CS/HAP composite membranes can accelerate bone regeneration without the contribution of endogenous cytokines.
35006786	2	16	theme	due	350:352	arg1	GBR					346:348	GBR	346:348	GBR due to its good mechanical and hydrophilic properties	346:402	Graphene oxide (GO) has been widely employed in GBR due to its good mechanical and hydrophilic properties.
35006786	3	17	theme	friendly	455:462	arg1	environment					464:474	a friendly environment	453:474	a friendly environment for osteogenic cell adhesion	453:503	A single GO membrane, however, does not provide a friendly environment for osteogenic cell adhesion.
35006786	5	18	theme	mineralization	960:973	arg1	method					975:980	a biomimetic mineralization method	947:980	a biomimetic mineralization method	947:980	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	8	19	theme	prepared	1189:1196	arg1	membranes					1208:1216	The prepared composite membranes	1185:1216	The prepared composite membranes	1185:1216	The prepared composite membranes were then implanted into a calvarial defect model to evaluate their osteogenic induction effects in vivo.
35006786	1	20	theme	surrounding	214:224	arg1	tissues					226:232	surrounding tissues	214:232	surrounding tissues	214:232	Two-dimensional materials provide a secluded space for bone formation and preserve the growth of surrounding tissues, thus playing a crucial role in guided bone regeneration (GBR).
35006786	2	21	theme	hydrophilic	381:391	arg1	properties					393:402	its good mechanical and hydrophilic properties	357:402	its good mechanical and hydrophilic properties	357:402	Graphene oxide (GO) has been widely employed in GBR due to its good mechanical and hydrophilic properties.
35006786	4	22	theme	composite	582:590	arg1	membranes					592:600	composite membranes	582:600	composite membranes	582:600	With their adjustable mechanical properties and excellent biocompatibility, composite membranes can simulate the multicomponent structure of an extracellular matrix for cell adhesion.
35006786	10	23	theme	biomimetic	1556:1565	arg1	structures					1574:1583	unique biomimetic porous structures	1549:1583	unique biomimetic porous structures	1549:1583	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	8	24	theme	calvarial	1245:1253	arg1	model					1262:1266	a calvarial defect model	1243:1266	a calvarial defect model to evaluate their osteogenic induction effects in vivo	1243:1321	The prepared composite membranes were then implanted into a calvarial defect model to evaluate their osteogenic induction effects in vivo.
35006786	5	25	with	membranes	716:724	arg1	biocompatibility					778:793	sufficient biocompatibility	767:793	sufficient biocompatibility	767:793	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	5	25	with	membranes	716:724	arg1	strength					754:761	appropriate mechanical strength	731:761	appropriate mechanical strength	731:761	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	0	26	theme	Oxide/Chitosan/Hydroxyapatite	9:37	arg1	Membranes					49:57	Graphene Oxide/Chitosan/Hydroxyapatite Composite Membranes	0:57	Graphene Oxide/Chitosan/Hydroxyapatite Composite Membranes	0:57	Graphene Oxide/Chitosan/Hydroxyapatite Composite Membranes Enhance Osteoblast Adhesion and Guided Bone Regeneration.
35006786	6	27	theme	mechanical	1007:1016	arg1	strength					1018:1025	mechanical strength	1007:1025	mechanical strength	1007:1025	CS and HAP improved the mechanical strength and surface hydrophilicity of the membranes.
35006786	5	28	theme	GO-based	796:803	arg1	membranes					815:823	GO-based composite membranes	796:823	GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP)	796:888	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	1	29	theme	Two-dimensional	117:131	arg1	materials					133:141	Two-dimensional materials	117:141	Two-dimensional materials	117:141	Two-dimensional materials provide a secluded space for bone formation and preserve the growth of surrounding tissues, thus playing a crucial role in guided bone regeneration (GBR).
35006786	9	30	theme	composite	1411:1419	arg1	membranes					1421:1429	GO/CS/HAP composite membranes	1401:1429	GO/CS/HAP composite membranes	1401:1429	Microcomputed tomography observation and histological analysis indicate that GO/CS/HAP composite membranes can accelerate bone regeneration without the contribution of endogenous cytokines.
35006786	2	31	theme	mechanical	366:375	arg1	properties					393:402	its good mechanical and hydrophilic properties	357:402	its good mechanical and hydrophilic properties	357:402	Graphene oxide (GO) has been widely employed in GBR due to its good mechanical and hydrophilic properties.
35006786	0	32	theme	Graphene	0:7	arg1	Membranes					49:57	Graphene Oxide/Chitosan/Hydroxyapatite Composite Membranes	0:57	Graphene Oxide/Chitosan/Hydroxyapatite Composite Membranes	0:57	Graphene Oxide/Chitosan/Hydroxyapatite Composite Membranes Enhance Osteoblast Adhesion and Guided Bone Regeneration.
35006786	6	33	theme	surface	1031:1037	arg1	hydrophilicity					1039:1052	surface hydrophilicity	1031:1052	surface hydrophilicity	1031:1052	CS and HAP improved the mechanical strength and surface hydrophilicity of the membranes.
35006786	3	34	dep	single	407:412	arg1	GO					414:415	GO	414:415	GO membrane	414:424	A single GO membrane, however, does not provide a friendly environment for osteogenic cell adhesion.
35006786	9	35	theme	Microcomputed	1324:1336	arg1	tomography					1338:1347	Microcomputed tomography	1324:1347	Microcomputed tomography observation	1324:1359	Microcomputed tomography observation and histological analysis indicate that GO/CS/HAP composite membranes can accelerate bone regeneration without the contribution of endogenous cytokines.
35006786	6	36	theme	membranes	1061:1069	arg1	strength					1018:1025	mechanical strength	1007:1025	mechanical strength	1007:1025	CS and HAP improved the mechanical strength and surface hydrophilicity of the membranes.
35006786	6	36	theme	membranes	1061:1069	arg1	hydrophilicity					1039:1052	surface hydrophilicity	1031:1052	surface hydrophilicity	1031:1052	CS and HAP improved the mechanical strength and surface hydrophilicity of the membranes.
35006786	2	37	theme	good	361:364	arg1	properties					393:402	its good mechanical and hydrophilic properties	357:402	its good mechanical and hydrophilic properties	357:402	Graphene oxide (GO) has been widely employed in GBR due to its good mechanical and hydrophilic properties.
35006786	9	38	theme	bone	1446:1449	arg1	regeneration					1451:1462	bone regeneration	1446:1462	bone regeneration	1446:1462	Microcomputed tomography observation and histological analysis indicate that GO/CS/HAP composite membranes can accelerate bone regeneration without the contribution of endogenous cytokines.
35006786	9	39	theme	endogenous	1492:1501	arg1	cytokines					1503:1511	endogenous cytokines	1492:1511	endogenous cytokines	1492:1511	Microcomputed tomography observation and histological analysis indicate that GO/CS/HAP composite membranes can accelerate bone regeneration without the contribution of endogenous cytokines.
35006786	0	40	theme	Composite	39:47	arg1	Membranes					49:57	Graphene Oxide/Chitosan/Hydroxyapatite Composite Membranes	0:57	Graphene Oxide/Chitosan/Hydroxyapatite Composite Membranes	0:57	Graphene Oxide/Chitosan/Hydroxyapatite Composite Membranes Enhance Osteoblast Adhesion and Guided Bone Regeneration.
35006786	5	41	theme	appropriate	731:741	arg1	strength					754:761	appropriate mechanical strength	731:761	appropriate mechanical strength	731:761	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	5	42	theme	biomimetic	949:958	arg1	method					975:980	a biomimetic mineralization method	947:980	a biomimetic mineralization method	947:980	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	10	43	with	membranes	1534:1542	arg1	properties					1606:1615	superior mechanical properties	1586:1615	superior mechanical properties	1586:1615	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	10	43	with	membranes	1534:1542	arg1	capacity					1650:1657	excellent bone regeneration capacity	1622:1657	excellent bone regeneration capacity	1622:1657	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	10	43	with	membranes	1534:1542	arg1	structures					1574:1583	unique biomimetic porous structures	1549:1583	unique biomimetic porous structures	1549:1583	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	0	44	theme	Osteoblast	67:76	arg1	Adhesion					78:85	Osteoblast Adhesion	67:85	Osteoblast Adhesion	67:85	Graphene Oxide/Chitosan/Hydroxyapatite Composite Membranes Enhance Osteoblast Adhesion and Guided Bone Regeneration.
35006786	4	45	theme	excellent	554:562	arg1	biocompatibility					564:579	excellent biocompatibility	554:579	excellent biocompatibility	554:579	With their adjustable mechanical properties and excellent biocompatibility, composite membranes can simulate the multicomponent structure of an extracellular matrix for cell adhesion.
35006786	5	46	theme	mechanical	743:752	arg1	strength					754:761	appropriate mechanical strength	731:761	appropriate mechanical strength	731:761	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	10	47	from	application	1687:1697	arg1	GBR					1702:1704	GBR	1702:1704	GBR	1702:1704	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	1	48	theme	tissues	226:232	arg1	growth					204:209	the growth	200:209	the growth of surrounding tissues	200:232	Two-dimensional materials provide a secluded space for bone formation and preserve the growth of surrounding tissues, thus playing a crucial role in guided bone regeneration (GBR).
35006786	4	49	theme	matrix	664:669	arg1	structure					634:642	the multicomponent structure	615:642	the multicomponent structure of an extracellular matrix for cell adhesion	615:687	With their adjustable mechanical properties and excellent biocompatibility, composite membranes can simulate the multicomponent structure of an extracellular matrix for cell adhesion.
35006786	4	50	theme	cell	675:678	arg1	adhesion					680:687	cell adhesion	675:687	cell adhesion	675:687	With their adjustable mechanical properties and excellent biocompatibility, composite membranes can simulate the multicomponent structure of an extracellular matrix for cell adhesion.
35006786	5	51	theme	one-step	916:923	arg1	filtration					932:941	one-step vacuum filtration	916:941	one-step vacuum filtration	916:941	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	10	52	theme	porous	1567:1572	arg1	structures					1574:1583	unique biomimetic porous structures	1549:1583	unique biomimetic porous structures	1549:1583	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	10	53	theme	excellent	1622:1630	arg1	capacity					1650:1657	excellent bone regeneration capacity	1622:1657	excellent bone regeneration capacity	1622:1657	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	4	54	theme	extracellular	650:662	arg1	matrix					664:669	an extracellular matrix	647:669	an extracellular matrix	647:669	With their adjustable mechanical properties and excellent biocompatibility, composite membranes can simulate the multicomponent structure of an extracellular matrix for cell adhesion.
35006786	8	55	theme	induction	1297:1305	arg1	effects					1307:1313	their osteogenic induction effects	1280:1313	their osteogenic induction effects	1280:1313	The prepared composite membranes were then implanted into a calvarial defect model to evaluate their osteogenic induction effects in vivo.
35006786	3	56	theme	osteogenic	480:489	arg1	adhesion					496:503	osteogenic cell adhesion	480:503	osteogenic cell adhesion	480:503	A single GO membrane, however, does not provide a friendly environment for osteogenic cell adhesion.
35006786	5	57	theme	composite	805:813	arg1	membranes					815:823	GO-based composite membranes	796:823	GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP)	796:888	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	7	58	theme	moderate	1085:1092	arg1	addition					1094:1101	moderate addition	1085:1101	moderate addition of HAP	1085:1108	In addition, moderate addition of HAP enhanced the adhesion, differentiation, and mineralization of osteoblasts.
35006786	1	59	theme	secluded	153:160	arg1	space					162:166	a secluded space	151:166	a secluded space for bone formation	151:185	Two-dimensional materials provide a secluded space for bone formation and preserve the growth of surrounding tissues, thus playing a crucial role in guided bone regeneration (GBR).
35006786	8	60	theme	osteogenic	1286:1295	arg1	effects					1307:1313	their osteogenic induction effects	1280:1313	their osteogenic induction effects	1280:1313	The prepared composite membranes were then implanted into a calvarial defect model to evaluate their osteogenic induction effects in vivo.
35006786	4	61	theme	mechanical	528:537	arg1	properties					539:548	their adjustable mechanical properties	511:548	their adjustable mechanical properties	511:548	With their adjustable mechanical properties and excellent biocompatibility, composite membranes can simulate the multicomponent structure of an extracellular matrix for cell adhesion.
35006786	7	62	theme	HAP	1106:1108	arg1	addition					1094:1101	moderate addition	1085:1101	moderate addition of HAP	1085:1108	In addition, moderate addition of HAP enhanced the adhesion, differentiation, and mineralization of osteoblasts.
35006786	6	63	dep	strength	1018:1025	arg1	the					1003:1005	the	1003:1005	the	1003:1005	CS and HAP improved the mechanical strength and surface hydrophilicity of the membranes.
35006786	4	64	theme	adjustable	517:526	arg1	properties					539:548	their adjustable mechanical properties	511:548	their adjustable mechanical properties	511:548	With their adjustable mechanical properties and excellent biocompatibility, composite membranes can simulate the multicomponent structure of an extracellular matrix for cell adhesion.
35006786	5	65	theme	two-dimensional	700:714	arg1	membranes					716:724	two-dimensional membranes	700:724	two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility	700:793	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	9	66	theme	tomography	1338:1347	arg1	observation					1349:1359	Microcomputed tomography observation	1324:1359	Microcomputed tomography observation	1324:1359	Microcomputed tomography observation and histological analysis indicate that GO/CS/HAP composite membranes can accelerate bone regeneration without the contribution of endogenous cytokines.
35006786	5	67	theme	vacuum	925:930	arg1	filtration					932:941	one-step vacuum filtration	916:941	one-step vacuum filtration	916:941	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	1	68	theme	crucial	250:256	arg1	role					258:261	a crucial role	248:261	a crucial role	248:261	Two-dimensional materials provide a secluded space for bone formation and preserve the growth of surrounding tissues, thus playing a crucial role in guided bone regeneration (GBR).
35006786	10	69	theme	mechanical	1595:1604	arg1	properties					1606:1615	superior mechanical properties	1586:1615	superior mechanical properties	1586:1615	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	1	70	theme	bone	172:175	arg1	formation					177:185	bone formation	172:185	bone formation	172:185	Two-dimensional materials provide a secluded space for bone formation and preserve the growth of surrounding tissues, thus playing a crucial role in guided bone regeneration (GBR).
35006786	0	71	theme	Bone	98:101	arg1	Regeneration					103:114	Guided Bone Regeneration	91:114	Guided Bone Regeneration	91:114	Graphene Oxide/Chitosan/Hydroxyapatite Composite Membranes Enhance Osteoblast Adhesion and Guided Bone Regeneration.
35006786	5	72	contain	containing	840:849	arg2	CS					861:862	CS	861:862	CS	861:862	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	5	72	contain	containing	840:849	arg2	hydroxyapatite					869:882	hydroxyapatite	869:882	hydroxyapatite (HAP)	869:888	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	5	72	contain	containing	840:849	arg1	membranes					815:823	GO-based composite membranes	796:823	GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP)	796:888	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	5	72	contain	containing	840:849	arg2	chitosan					851:858	chitosan	851:858	chitosan (CS)	851:863	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	5	72	contain	containing	840:849	arg2	HAP					885:887	HAP	885:887	HAP	885:887	To obtain two-dimensional membranes with appropriate mechanical strength and sufficient biocompatibility, GO-based composite membranes simultaneously containing chitosan (CS) and hydroxyapatite (HAP) were first prepared using one-step vacuum filtration and a biomimetic mineralization method.
35006786	10	73	theme	potential	1663:1671	arg1	materials					1673:1681	potential materials	1663:1681	potential materials for application in GBR	1663:1704	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	10	73	theme	potential	1663:1671	arg1	membranes					1534:1542	GO/CS/HAP composite membranes	1514:1542	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity	1514:1657	GO/CS/HAP composite membranes with unique biomimetic porous structures, superior mechanical properties, and excellent bone regeneration capacity are potential materials for application in GBR.
35006786	0	74	theme	Guided	91:96	arg1	Regeneration					103:114	Guided Bone Regeneration	91:114	Guided Bone Regeneration	91:114	Graphene Oxide/Chitosan/Hydroxyapatite Composite Membranes Enhance Osteoblast Adhesion and Guided Bone Regeneration.
35006786	9	75	theme	histological	1365:1376	arg1	analysis					1378:1385	histological analysis	1365:1385	histological analysis	1365:1385	Microcomputed tomography observation and histological analysis indicate that GO/CS/HAP composite membranes can accelerate bone regeneration without the contribution of endogenous cytokines.
35006786	4	76	theme	multicomponent	619:632	arg1	structure					634:642	the multicomponent structure	615:642	the multicomponent structure of an extracellular matrix for cell adhesion	615:687	With their adjustable mechanical properties and excellent biocompatibility, composite membranes can simulate the multicomponent structure of an extracellular matrix for cell adhesion.
35006786	8	77	theme	defect	1255:1260	arg1	model					1262:1266	a calvarial defect model	1243:1266	a calvarial defect model to evaluate their osteogenic induction effects in vivo	1243:1321	The prepared composite membranes were then implanted into a calvarial defect model to evaluate their osteogenic induction effects in vivo.
35006786	1	78	theme	guided	266:271	arg1	regeneration					278:289	guided bone regeneration	266:289	guided bone regeneration (GBR)	266:295	Two-dimensional materials provide a secluded space for bone formation and preserve the growth of surrounding tissues, thus playing a crucial role in guided bone regeneration (GBR).
35006786	1	78	theme	guided	266:271	arg1	GBR					292:294	GBR	292:294	GBR	292:294	Two-dimensional materials provide a secluded space for bone formation and preserve the growth of surrounding tissues, thus playing a crucial role in guided bone regeneration (GBR).
34734702	6	0	dep	32	1172:1173	arg1	to					1169:1170	to	1169:1170	to	1169:1170	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	4	1	theme	Free-standing	644:656	arg1	films					658:662	Free-standing films	644:662	Free-standing films of the composites	644:680	Free-standing films of the composites can be prepared by simple solvent casting from water.
34734702	4	2	from	water	729:733	arg1	casting					716:722	simple solvent casting	701:722	simple solvent casting from water	701:733	Free-standing films of the composites can be prepared by simple solvent casting from water.
34734702	2	3	theme	attainable	346:355	arg1	reinforcement					357:369	the attainable reinforcement	342:369	the attainable reinforcement	342:369	However, CNCs are prone to aggregation and this limits the attainable reinforcement.
34734702	1	4	theme	reinforcing	238:248	arg1	component					250:258	a reinforcing component	236:258	a reinforcing component in polymer nanocomposites	236:284	On account of their high strength and stiffness and their renewable nature, cellulose nanocrystals (CNCs) are widely used as a reinforcing component in polymer nanocomposites.
34734702	1	4	theme	reinforcing	238:248	arg1	nanocrystals					197:208	cellulose nanocrystals	187:208	cellulose nanocrystals (CNCs)	187:215	On account of their high strength and stiffness and their renewable nature, cellulose nanocrystals (CNCs) are widely used as a reinforcing component in polymer nanocomposites.
34734702	0	5	theme	Cationic	93:100	arg1	Polymer					102:108	a Cationic Polymer	91:108	a Cationic Polymer	91:108	Nanocomposites Assembled via Electrostatic Interactions between Cellulose Nanocrystals and a Cationic Polymer.
34734702	1	6	theme	renewable	169:177	arg1	nature					179:184	their renewable nature	163:184	their renewable nature	163:184	On account of their high strength and stiffness and their renewable nature, cellulose nanocrystals (CNCs) are widely used as a reinforcing component in polymer nanocomposites.
34734702	6	7	theme	maximum	1134:1140	arg1	strength					1142:1149	the maximum strength	1130:1149	the maximum strength	1130:1149	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	4	8	theme	solvent	708:714	arg1	casting					716:722	simple solvent casting	701:722	simple solvent casting from water	701:733	Free-standing films of the composites can be prepared by simple solvent casting from water.
34734702	4	9	theme	simple	701:706	arg1	casting					716:722	simple solvent casting	701:722	simple solvent casting from water	701:733	Free-standing films of the composites can be prepared by simple solvent casting from water.
34734702	3	10	with	nanocomposites	391:404	arg1	content					427:433	a very high CNC content	411:433	a very high CNC content	411:433	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	1	11	theme	polymer	263:269	arg1	nanocomposites					271:284	polymer nanocomposites	263:284	polymer nanocomposites	263:284	On account of their high strength and stiffness and their renewable nature, cellulose nanocrystals (CNCs) are widely used as a reinforcing component in polymer nanocomposites.
34734702	6	12	theme	matrix	1076:1081	arg1	polymer					1083:1089	this already rather stiff, glassy amorphous matrix polymer	1032:1089	polymer	1083:1089	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	3	13	theme	methacryloyloxy	494:508	arg1	ethyl					510:514	2-(methacryloyloxy)ethyl	491:514	2-(methacryloyloxy)ethyl	491:514	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	3	13	theme	methacryloyloxy	494:508	arg1	poly[					485:489	the cationic polymer poly[	464:489	the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC)	464:552	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	5	14	theme	films	824:828	arg1	images					808:813	polarized optical microscopy and electron microscopy images	755:813	polarized optical microscopy and electron microscopy images	755:813	The appearance and polarized optical microscopy and electron microscopy images of these films suggest that CNC aggregation is absent, and this is supported by the very pronounced reinforcement observed.
34734702	5	14	theme	films	824:828	arg1	appearance					740:749	appearance	740:749	appearance	740:749	The appearance and polarized optical microscopy and electron microscopy images of these films suggest that CNC aggregation is absent, and this is supported by the very pronounced reinforcement observed.
34734702	3	15	theme	CNC	423:425	arg1	content					427:433	a very high CNC content	411:433	a very high CNC content	411:433	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	7	16	theme	unmodified	1354:1363	arg1	CNC-OH					1371:1376	CNC-OH	1371:1376	CNC-OH	1371:1376	At this high CNC content, the reinforcement achieved in the PMETAC/CNC-COONa nanocomposite is much more pronounced than that observed for a reference nanocomposite made with unmodified CNCs (CNC-OH).
34734702	7	16	theme	unmodified	1354:1363	arg1	CNCs					1365:1368	unmodified CNCs	1354:1368	unmodified CNCs (CNC-OH)	1354:1377	At this high CNC content, the reinforcement achieved in the PMETAC/CNC-COONa nanocomposite is much more pronounced than that observed for a reference nanocomposite made with unmodified CNCs (CNC-OH).
34734702	5	17	dep	appearance	740:749	arg1	The					736:738	The	736:738	The	736:738	The appearance and polarized optical microscopy and electron microscopy images of these films suggest that CNC aggregation is absent, and this is supported by the very pronounced reinforcement observed.
34734702	6	18	theme	0.3	1102:1104	arg1	±					1113:1113	±	1113:1113	±	1113:1113	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	6	19	dep	polymer	1083:1089	arg1	glassy					1059:1064	this already rather stiff, glassy amorphous matrix polymer	1032:1089	glassy	1059:1064	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	7	20	theme	high	1188:1191	arg1	content					1197:1203	this high CNC content	1183:1203	this high CNC content	1183:1203	At this high CNC content, the reinforcement achieved in the PMETAC/CNC-COONa nanocomposite is much more pronounced than that observed for a reference nanocomposite made with unmodified CNCs (CNC-OH).
34734702	1	21	theme	cellulose	187:195	arg1	CNCs					211:214	CNCs	211:214	CNCs	211:214	On account of their high strength and stiffness and their renewable nature, cellulose nanocrystals (CNCs) are widely used as a reinforcing component in polymer nanocomposites.
34734702	1	21	theme	cellulose	187:195	arg1	nanocrystals					197:208	cellulose nanocrystals	187:208	cellulose nanocrystals (CNCs)	187:215	On account of their high strength and stiffness and their renewable nature, cellulose nanocrystals (CNCs) are widely used as a reinforcing component in polymer nanocomposites.
34734702	1	21	theme	cellulose	187:195	arg1	component					250:258	a reinforcing component	236:258	a reinforcing component in polymer nanocomposites	236:284	On account of their high strength and stiffness and their renewable nature, cellulose nanocrystals (CNCs) are widely used as a reinforcing component in polymer nanocomposites.
34734702	5	22	theme	polarized	755:763	arg1	images					808:813	polarized optical microscopy and electron microscopy images	755:813	polarized optical microscopy and electron microscopy images	755:813	The appearance and polarized optical microscopy and electron microscopy images of these films suggest that CNC aggregation is absent, and this is supported by the very pronounced reinforcement observed.
34734702	3	23	theme	high	418:421	arg1	content					427:433	a very high CNC content	411:433	a very high CNC content	411:433	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	0	24	theme	Electrostatic	29:41	arg1	Interactions					43:54	Electrostatic Interactions	29:54	Electrostatic Interactions between Cellulose Nanocrystals and a Cationic Polymer	29:108	Nanocomposites Assembled via Electrostatic Interactions between Cellulose Nanocrystals and a Cationic Polymer.
34734702	3	25	theme	trimethylammonium	517:533	arg1	chloride					535:542	trimethylammonium chloride	517:542	trimethylammonium chloride	517:542	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	3	26	dep	charged	569:575	arg1	carboxylated					578:589	carboxylated	578:589	carboxylated	578:589	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	5	27	theme	microscopy	773:782	arg1	images					808:813	polarized optical microscopy and electron microscopy images	755:813	polarized optical microscopy and electron microscopy images	755:813	The appearance and polarized optical microscopy and electron microscopy images of these films suggest that CNC aggregation is absent, and this is supported by the very pronounced reinforcement observed.
34734702	7	28	theme	reference	1320:1328	arg1	nanocomposite					1330:1342	a reference nanocomposite	1318:1342	a reference nanocomposite made with unmodified CNCs (CNC-OH)	1318:1377	At this high CNC content, the reinforcement achieved in the PMETAC/CNC-COONa nanocomposite is much more pronounced than that observed for a reference nanocomposite made with unmodified CNCs (CNC-OH).
34734702	6	29	dep	±	1113:1113	arg1	to					1106:1107	to	1106:1107	to	1106:1107	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	6	30	theme	polymer	1083:1089	arg1	modulus					1021:1027	the storage modulus	1009:1027	the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa	1009:1121	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	6	31	from	±	1100:1100	arg1	modulus					1021:1027	the storage modulus	1009:1027	the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa	1009:1121	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	5	32	theme	electron	788:795	arg1	microscopy					797:806	electron microscopy	788:806	electron microscopy	788:806	The appearance and polarized optical microscopy and electron microscopy images of these films suggest that CNC aggregation is absent, and this is supported by the very pronounced reinforcement observed.
34734702	7	33	theme	CNC	1193:1195	arg1	content					1197:1203	this high CNC content	1183:1203	this high CNC content	1183:1203	At this high CNC content, the reinforcement achieved in the PMETAC/CNC-COONa nanocomposite is much more pronounced than that observed for a reference nanocomposite made with unmodified CNCs (CNC-OH).
34734702	3	34	theme	polymer	477:483	arg1	ethyl					510:514	2-(methacryloyloxy)ethyl	491:514	2-(methacryloyloxy)ethyl	491:514	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	3	34	theme	polymer	477:483	arg1	PMETAC					546:551	PMETAC	546:551	PMETAC	546:551	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	3	34	theme	polymer	477:483	arg1	poly[					485:489	the cationic polymer poly[	464:489	the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC)	464:552	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	6	35	theme	amorphous	1066:1074	arg1	polymer					1083:1089	this already rather stiff, glassy amorphous matrix polymer	1032:1089	polymer	1083:1089	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	5	36	theme	microscopy	797:806	arg1	images					808:813	polarized optical microscopy and electron microscopy images	755:813	polarized optical microscopy and electron microscopy images	755:813	The appearance and polarized optical microscopy and electron microscopy images of these films suggest that CNC aggregation is absent, and this is supported by the very pronounced reinforcement observed.
34734702	1	37	from	component	250:258	arg1	nanocomposites					271:284	polymer nanocomposites	263:284	polymer nanocomposites	263:284	On account of their high strength and stiffness and their renewable nature, cellulose nanocrystals (CNCs) are widely used as a reinforcing component in polymer nanocomposites.
34734702	5	38	theme	optical	765:771	arg1	microscopy					773:782	optical microscopy	765:782	optical microscopy	765:782	The appearance and polarized optical microscopy and electron microscopy images of these films suggest that CNC aggregation is absent, and this is supported by the very pronounced reinforcement observed.
34734702	6	39	theme	storage	1013:1019	arg1	modulus					1021:1027	the storage modulus	1009:1027	the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa	1009:1121	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	5	40	theme	pronounced	904:913	arg1	reinforcement					915:927	the very pronounced reinforcement	895:927	the very pronounced reinforcement observed	895:936	The appearance and polarized optical microscopy and electron microscopy images of these films suggest that CNC aggregation is absent, and this is supported by the very pronounced reinforcement observed.
34734702	3	41	theme	cationic	468:475	arg1	ethyl					510:514	2-(methacryloyloxy)ethyl	491:514	2-(methacryloyloxy)ethyl	491:514	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	3	41	theme	cationic	468:475	arg1	PMETAC					546:551	PMETAC	546:551	PMETAC	546:551	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	3	41	theme	cationic	468:475	arg1	poly[					485:489	the cationic polymer poly[	464:489	the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC)	464:552	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	0	42	theme	Cellulose	64:72	arg1	Nanocrystals					74:85	Cellulose Nanocrystals	64:85	Cellulose Nanocrystals	64:85	Nanocomposites Assembled via Electrostatic Interactions between Cellulose Nanocrystals and a Cationic Polymer.
34734702	6	43	theme	6.6	1109:1111	arg1	±					1113:1113	±	1113:1113	±	1113:1113	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	7	44	from	content	1197:1203	arg1	reinforcement					1210:1222	the reinforcement	1206:1222	the reinforcement achieved in the PMETAC/CNC-COONa nanocomposite	1206:1269	At this high CNC content, the reinforcement achieved in the PMETAC/CNC-COONa nanocomposite is much more pronounced than that observed for a reference nanocomposite made with unmodified CNCs (CNC-OH).
34734702	7	44	from	content	1197:1203	arg1	pronounced					1284:1293	pronounced	1284:1293	pronounced	1284:1293	At this high CNC content, the reinforcement achieved in the PMETAC/CNC-COONa nanocomposite is much more pronounced than that observed for a reference nanocomposite made with unmodified CNCs (CNC-OH).
34734702	1	45	theme	high	131:134	arg1	strength					136:143	their high strength	125:143	their high strength	125:143	On account of their high strength and stiffness and their renewable nature, cellulose nanocrystals (CNCs) are widely used as a reinforcing component in polymer nanocomposites.
34734702	7	46	theme	PMETAC/CNC-COONa	1240:1255	arg1	nanocomposite					1257:1269	the PMETAC/CNC-COONa nanocomposite	1236:1269	the PMETAC/CNC-COONa nanocomposite	1236:1269	At this high CNC content, the reinforcement achieved in the PMETAC/CNC-COONa nanocomposite is much more pronounced than that observed for a reference nanocomposite made with unmodified CNCs (CNC-OH).
34734702	6	47	theme	%	966:966	arg1	CNC-COONa					968:976	33 wt % CNC-COONa	960:976	33 wt % CNC-COONa	960:976	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	3	48	dep	ethyl	510:514	arg1	chloride					535:542	trimethylammonium chloride	517:542	trimethylammonium chloride	517:542	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	6	49	theme	CNC-COONa	968:976	arg1	incorporation					943:955	The incorporation	939:955	The incorporation of 33 wt % CNC-COONa into PMETAC	939:988	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	1	50	used	used	228:231	arg2	CNCs					211:214	CNCs	211:214	CNCs	211:214	On account of their high strength and stiffness and their renewable nature, cellulose nanocrystals (CNCs) are widely used as a reinforcing component in polymer nanocomposites.
34734702	1	50	used	used	228:231	arg2	nanocrystals					197:208	cellulose nanocrystals	187:208	cellulose nanocrystals (CNCs)	187:215	On account of their high strength and stiffness and their renewable nature, cellulose nanocrystals (CNCs) are widely used as a reinforcing component in polymer nanocomposites.
34734702	1	50	used	used	228:231	arg2	component					250:258	a reinforcing component	236:258	a reinforcing component in polymer nanocomposites	236:284	On account of their high strength and stiffness and their renewable nature, cellulose nanocrystals (CNCs) are widely used as a reinforcing component in polymer nanocomposites.
34734702	4	51	theme	composites	671:680	arg1	films					658:662	Free-standing films	644:662	Free-standing films of the composites	644:680	Free-standing films of the composites can be prepared by simple solvent casting from water.
34734702	3	52	theme	sodium	619:624	arg1	CNC-COONa					632:640	CNC-COONa	632:640	CNC-COONa	632:640	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	3	52	theme	sodium	619:624	arg1	salt					626:629	a sodium salt	617:629	a sodium salt (CNC-COONa)	617:641	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	3	52	theme	sodium	619:624	arg1	CNCs					591:594	negatively charged, carboxylated CNCs	558:594	negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa)	558:641	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	3	53	theme	charged	569:575	arg1	salt					626:629	a sodium salt	617:629	a sodium salt (CNC-COONa)	617:641	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	3	53	theme	charged	569:575	arg1	CNCs					591:594	negatively charged, carboxylated CNCs	558:594	negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa)	558:641	Here, we show that nanocomposites with a very high CNC content can be prepared by combining the cationic polymer poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) and negatively charged, carboxylated CNCs that are provided as a sodium salt (CNC-COONa).
34734702	6	54	theme	stiff	1052:1056	arg1	polymer					1083:1089	this already rather stiff, glassy amorphous matrix polymer	1032:1089	polymer	1083:1089	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	6	55	theme	wt	963:964	arg1	CNC-COONa					968:976	33 wt % CNC-COONa	960:976	33 wt % CNC-COONa	960:976	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	6	56	theme	0.1	1115:1117	arg1	±					1113:1113	±	1113:1113	±	1113:1113	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	6	57	dep	±	1100:1100	arg1	GPa					1119:1121	0.3 to 6.6 ± 0.1 GPa	1102:1121	1.5 ± 0.3 to 6.6 ± 0.1 GPa	1096:1121	The incorporation of 33 wt % CNC-COONa into PMETAC allowed increasing the storage modulus of this already rather stiff, glassy amorphous matrix polymer from 1.5 ± 0.3 to 6.6 ± 0.1 GPa, while the maximum strength increased from 11 to 32 MPa.
34734702	5	58	theme	CNC	843:845	arg1	aggregation					847:857	CNC aggregation	843:857	CNC aggregation	843:857	The appearance and polarized optical microscopy and electron microscopy images of these films suggest that CNC aggregation is absent, and this is supported by the very pronounced reinforcement observed.
32818709	6	0	theme	red	1222:1224	arg1	luminescence					1226:1237	fine red luminescence	1217:1237	fine red luminescence	1217:1237	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	3	1	theme	stimuli-responsive	632:649	arg1	properties					651:660	obvious thermo/pH stimuli-responsive properties	614:660	obvious thermo/pH stimuli-responsive properties	614:660	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	3	1	theme	stimuli-responsive	632:649	arg1	reservoir					705:713	a drug storage reservoir	690:713	a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX)	690:778	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	0	2	theme	delivery	131:138	arg1	system					140:145	thermo/pH dual-stimuli-responsive and luminescent drug delivery system	76:145	thermo/pH dual-stimuli-responsive and luminescent drug delivery system	76:145	Fabrication of PNIPAM-chitosan/decatungstoeuropate/silica nanocomposite for thermo/pH dual-stimuli-responsive and luminescent drug delivery system.
32818709	1	3	theme	poly	232:235	arg1	-chitosan					260:268	poly (N-isopropylacrylamide)-chitosan	232:268	poly (N-isopropylacrylamide)-chitosan	232:268	A luminescent and dual-stimuli-responsive nanocomposite based on mesoporous silica, poly (N-isopropylacrylamide)-chitosan and decatungstoeuropate was prepared.
32818709	4	4	theme	fast	917:920	arg1	release					922:928	the fast release	913:928	the fast release of drug	913:936	The research indicated that the releases of DOX were thermo/pH dependent and high temperatures/acidic conditions were favorable for the fast release of drug.
32818709	6	5	theme	medicine	1347:1354	arg1	field					1338:1342	field	1338:1342	field of medicine	1338:1354	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	4	6	theme	temperatures/acidic	863:881	arg1	conditions					883:892	high temperatures/acidic conditions	858:892	high temperatures/acidic conditions	858:892	The research indicated that the releases of DOX were thermo/pH dependent and high temperatures/acidic conditions were favorable for the fast release of drug.
32818709	2	7	theme	poly	419:422	arg1	-chitosan					447:455	thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan	393:455	thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan	393:455	To fabricate the nanocomposite, the mesoporous silica nanoparticles were coated with thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan and the luminescent decatungstoeuropate particles were grafted onto copolymers.
32818709	6	8	theme	labeling	1317:1324	arg1	material					1326:1333	a potential labeling material	1305:1333	a potential labeling material in field of medicine	1305:1354	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	6	8	theme	labeling	1317:1324	arg1	temperatures					1250:1261	various temperatures	1242:1261	various temperatures	1242:1261	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	6	8	theme	labeling	1317:1324	arg1	values					1270:1275	pH values	1267:1275	pH values	1267:1275	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	5	9	dep	In	939:940	arg1	vitro					942:946	vitro	942:946	vitro	942:946	In vitro cytotoxicity tests revealed that the drug delivery carrier displayed excellent biocompatible and the composites loaded with DOX showed significant suppression effect on HeLa cells.
32818709	5	10	theme	HeLa	1117:1120	arg1	cells					1122:1126	HeLa cells	1117:1126	HeLa cells	1117:1126	In vitro cytotoxicity tests revealed that the drug delivery carrier displayed excellent biocompatible and the composites loaded with DOX showed significant suppression effect on HeLa cells.
32818709	6	11	theme	Luminescence	1129:1140	arg1	spectra					1142:1148	Luminescence spectra	1129:1148	Luminescence spectra	1129:1148	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	3	12	theme	obvious	614:620	arg1	properties					651:660	obvious thermo/pH stimuli-responsive properties	614:660	obvious thermo/pH stimuli-responsive properties	614:660	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	3	12	theme	obvious	614:620	arg1	reservoir					705:713	a drug storage reservoir	690:713	a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX)	690:778	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	4	13	theme	high	858:861	arg1	conditions					883:892	high temperatures/acidic conditions	858:892	high temperatures/acidic conditions	858:892	The research indicated that the releases of DOX were thermo/pH dependent and high temperatures/acidic conditions were favorable for the fast release of drug.
32818709	4	14	dep	the	809:811	arg1	releases					813:820	releases	813:820	releases	813:820	The research indicated that the releases of DOX were thermo/pH dependent and high temperatures/acidic conditions were favorable for the fast release of drug.
32818709	6	15	theme	various	1242:1248	arg1	material					1326:1333	a potential labeling material	1305:1333	a potential labeling material in field of medicine	1305:1354	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	6	15	theme	various	1242:1248	arg1	temperatures					1250:1261	various temperatures	1242:1261	various temperatures	1242:1261	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	6	15	theme	various	1242:1248	arg1	values					1270:1275	pH values	1267:1275	pH values	1267:1275	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	5	16	theme	drug	985:988	arg1	carrier					999:1005	the drug delivery carrier	981:1005	the drug delivery carrier	981:1005	In vitro cytotoxicity tests revealed that the drug delivery carrier displayed excellent biocompatible and the composites loaded with DOX showed significant suppression effect on HeLa cells.
32818709	2	17	theme	silica	355:360	arg1	nanoparticles					362:374	the mesoporous silica nanoparticles	340:374	the mesoporous silica nanoparticles	340:374	To fabricate the nanocomposite, the mesoporous silica nanoparticles were coated with thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan and the luminescent decatungstoeuropate particles were grafted onto copolymers.
32818709	6	18	theme	pH	1267:1268	arg1	material					1326:1333	a potential labeling material	1305:1333	a potential labeling material in field of medicine	1305:1354	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	6	18	theme	pH	1267:1268	arg1	temperatures					1250:1261	various temperatures	1242:1261	various temperatures	1242:1261	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	6	18	theme	pH	1267:1268	arg1	values					1270:1275	pH values	1267:1275	pH values	1267:1275	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	5	19	theme	delivery	990:997	arg1	carrier					999:1005	the drug delivery carrier	981:1005	the drug delivery carrier	981:1005	In vitro cytotoxicity tests revealed that the drug delivery carrier displayed excellent biocompatible and the composites loaded with DOX showed significant suppression effect on HeLa cells.
32818709	3	20	theme	storage	697:703	arg1	properties					651:660	obvious thermo/pH stimuli-responsive properties	614:660	obvious thermo/pH stimuli-responsive properties	614:660	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	3	20	theme	storage	697:703	arg1	reservoir					705:713	a drug storage reservoir	690:713	a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX)	690:778	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	3	21	dep	loading	723:729	arg1	the					719:721	the	719:721	the	719:721	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	5	22	theme	In	939:940	arg1	tests					961:965	In vitro cytotoxicity tests	939:965	In vitro cytotoxicity tests	939:965	In vitro cytotoxicity tests revealed that the drug delivery carrier displayed excellent biocompatible and the composites loaded with DOX showed significant suppression effect on HeLa cells.
32818709	2	23	theme	dual-responsive	403:417	arg1	-chitosan					447:455	thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan	393:455	thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan	393:455	To fabricate the nanocomposite, the mesoporous silica nanoparticles were coated with thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan and the luminescent decatungstoeuropate particles were grafted onto copolymers.
32818709	2	24	theme	thermo/pH	393:401	arg1	-chitosan					447:455	thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan	393:455	thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan	393:455	To fabricate the nanocomposite, the mesoporous silica nanoparticles were coated with thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan and the luminescent decatungstoeuropate particles were grafted onto copolymers.
32818709	0	25	theme	PNIPAM-chitosan/decatungstoeuropate/silica	15:56	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of PNIPAM-chitosan/decatungstoeuropate/silica	0:56	Fabrication of PNIPAM-chitosan/decatungstoeuropate/silica nanocomposite for thermo/pH dual-stimuli-responsive and luminescent drug delivery system.
32818709	5	26	theme	significant	1083:1093	arg1	effect					1107:1112	significant suppression effect	1083:1112	significant suppression effect on HeLa cells	1083:1126	In vitro cytotoxicity tests revealed that the drug delivery carrier displayed excellent biocompatible and the composites loaded with DOX showed significant suppression effect on HeLa cells.
32818709	5	27	theme	suppression	1095:1105	arg1	effect					1107:1112	significant suppression effect	1083:1112	significant suppression effect on HeLa cells	1083:1126	In vitro cytotoxicity tests revealed that the drug delivery carrier displayed excellent biocompatible and the composites loaded with DOX showed significant suppression effect on HeLa cells.
32818709	3	28	theme	drug	692:695	arg1	properties					651:660	obvious thermo/pH stimuli-responsive properties	614:660	obvious thermo/pH stimuli-responsive properties	614:660	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	3	28	theme	drug	692:695	arg1	reservoir					705:713	a drug storage reservoir	690:713	a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX)	690:778	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	6	29	from	material	1326:1333	arg1	field					1338:1342	field	1338:1342	field of medicine	1338:1354	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	1	30	theme	mesoporous	213:222	arg1	silica					224:229	mesoporous silica	213:229	mesoporous silica	213:229	A luminescent and dual-stimuli-responsive nanocomposite based on mesoporous silica, poly (N-isopropylacrylamide)-chitosan and decatungstoeuropate was prepared.
32818709	0	31	theme	thermo/pH	76:84	arg1	system					140:145	thermo/pH dual-stimuli-responsive and luminescent drug delivery system	76:145	thermo/pH dual-stimuli-responsive and luminescent drug delivery system	76:145	Fabrication of PNIPAM-chitosan/decatungstoeuropate/silica nanocomposite for thermo/pH dual-stimuli-responsive and luminescent drug delivery system.
32818709	6	32	theme	fine	1217:1220	arg1	luminescence					1226:1237	fine red luminescence	1217:1237	fine red luminescence	1217:1237	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	3	33	theme	good	581:584	arg1	luminescence					590:601	good red luminescence	581:601	good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX)	581:778	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	3	34	theme	designed	541:548	arg1	nanocarrier					550:560	The designed nanocarrier	537:560	The designed nanocarrier	537:560	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	3	35	theme	doxorubicin	762:772	arg1	loading					723:729	loading	723:729	loading	723:729	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	3	35	theme	doxorubicin	762:772	arg1	release					735:741	release	735:741	release	735:741	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	3	36	theme	red	586:588	arg1	luminescence					590:601	good red luminescence	581:601	good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX)	581:778	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	1	37	theme	dual-stimuli-responsive	166:188	arg1	nanocomposite					190:202	A luminescent and dual-stimuli-responsive nanocomposite	148:202	A luminescent and dual-stimuli-responsive nanocomposite based on mesoporous silica, poly (N-isopropylacrylamide)-chitosan and decatungstoeuropate	148:292	A luminescent and dual-stimuli-responsive nanocomposite based on mesoporous silica, poly (N-isopropylacrylamide)-chitosan and decatungstoeuropate was prepared.
32818709	0	38	theme	dual-stimuli-responsive	86:108	arg1	system					140:145	thermo/pH dual-stimuli-responsive and luminescent drug delivery system	76:145	thermo/pH dual-stimuli-responsive and luminescent drug delivery system	76:145	Fabrication of PNIPAM-chitosan/decatungstoeuropate/silica nanocomposite for thermo/pH dual-stimuli-responsive and luminescent drug delivery system.
32818709	6	39	theme	potential	1307:1315	arg1	material					1326:1333	a potential labeling material	1305:1333	a potential labeling material in field of medicine	1305:1354	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	6	39	theme	potential	1307:1315	arg1	temperatures					1250:1261	various temperatures	1242:1261	various temperatures	1242:1261	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	6	39	theme	potential	1307:1315	arg1	values					1270:1275	pH values	1267:1275	pH values	1267:1275	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	3	40	theme	thermo/pH	622:630	arg1	properties					651:660	obvious thermo/pH stimuli-responsive properties	614:660	obvious thermo/pH stimuli-responsive properties	614:660	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	3	40	theme	thermo/pH	622:630	arg1	reservoir					705:713	a drug storage reservoir	690:713	a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX)	690:778	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	3	41	theme	anticancer	746:755	arg1	DOX					775:777	DOX	775:777	DOX	775:777	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	3	41	theme	anticancer	746:755	arg1	doxorubicin					762:772	anticancer drug doxorubicin	746:772	anticancer drug doxorubicin (DOX)	746:778	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	2	42	theme	mesoporous	344:353	arg1	nanoparticles					362:374	the mesoporous silica nanoparticles	340:374	the mesoporous silica nanoparticles	340:374	To fabricate the nanocomposite, the mesoporous silica nanoparticles were coated with thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan and the luminescent decatungstoeuropate particles were grafted onto copolymers.
32818709	2	43	theme	N-isopropylacrylamide	425:445	arg1	-chitosan					447:455	thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan	393:455	thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan	393:455	To fabricate the nanocomposite, the mesoporous silica nanoparticles were coated with thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan and the luminescent decatungstoeuropate particles were grafted onto copolymers.
32818709	1	44	theme	luminescent	150:160	arg1	nanocomposite					190:202	A luminescent and dual-stimuli-responsive nanocomposite	148:202	A luminescent and dual-stimuli-responsive nanocomposite based on mesoporous silica, poly (N-isopropylacrylamide)-chitosan and decatungstoeuropate	148:292	A luminescent and dual-stimuli-responsive nanocomposite based on mesoporous silica, poly (N-isopropylacrylamide)-chitosan and decatungstoeuropate was prepared.
32818709	3	45	theme	drug	757:760	arg1	DOX					775:777	DOX	775:777	DOX	775:777	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	3	45	theme	drug	757:760	arg1	doxorubicin					762:772	anticancer drug doxorubicin	746:772	anticancer drug doxorubicin (DOX)	746:778	The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of anticancer drug doxorubicin (DOX).
32818709	6	46	theme	containing	1176:1185	arg1	decatungstoeuropate					1187:1205	the composite containing decatungstoeuropate	1162:1205	the composite containing decatungstoeuropate	1162:1205	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	0	47	theme	drug	126:129	arg1	system					140:145	thermo/pH dual-stimuli-responsive and luminescent drug delivery system	76:145	thermo/pH dual-stimuli-responsive and luminescent drug delivery system	76:145	Fabrication of PNIPAM-chitosan/decatungstoeuropate/silica nanocomposite for thermo/pH dual-stimuli-responsive and luminescent drug delivery system.
32818709	4	48	theme	drug	933:936	arg1	release					922:928	the fast release	913:928	the fast release of drug	913:936	The research indicated that the releases of DOX were thermo/pH dependent and high temperatures/acidic conditions were favorable for the fast release of drug.
32818709	2	49	theme	decatungstoeuropate	477:495	arg1	particles					497:505	the luminescent decatungstoeuropate particles	461:505	the luminescent decatungstoeuropate particles	461:505	To fabricate the nanocomposite, the mesoporous silica nanoparticles were coated with thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan and the luminescent decatungstoeuropate particles were grafted onto copolymers.
32818709	5	50	from	effect	1107:1112	arg1	cells					1122:1126	HeLa cells	1117:1126	HeLa cells	1117:1126	In vitro cytotoxicity tests revealed that the drug delivery carrier displayed excellent biocompatible and the composites loaded with DOX showed significant suppression effect on HeLa cells.
32818709	6	51	theme	composite	1166:1174	arg1	decatungstoeuropate					1187:1205	the composite containing decatungstoeuropate	1162:1205	the composite containing decatungstoeuropate	1162:1205	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	0	52	theme	luminescent	114:124	arg1	system					140:145	thermo/pH dual-stimuli-responsive and luminescent drug delivery system	76:145	thermo/pH dual-stimuli-responsive and luminescent drug delivery system	76:145	Fabrication of PNIPAM-chitosan/decatungstoeuropate/silica nanocomposite for thermo/pH dual-stimuli-responsive and luminescent drug delivery system.
32818709	5	53	theme	cytotoxicity	948:959	arg1	tests					961:965	In vitro cytotoxicity tests	939:965	In vitro cytotoxicity tests	939:965	In vitro cytotoxicity tests revealed that the drug delivery carrier displayed excellent biocompatible and the composites loaded with DOX showed significant suppression effect on HeLa cells.
32818709	6	54	used	utilized	1293:1300	arg2	temperatures					1250:1261	various temperatures	1242:1261	various temperatures	1242:1261	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	6	54	used	utilized	1293:1300	arg2	material					1326:1333	a potential labeling material	1305:1333	a potential labeling material in field of medicine	1305:1354	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	6	54	used	utilized	1293:1300	arg2	values					1270:1275	pH values	1267:1275	pH values	1267:1275	Luminescence spectra showed that the composite containing decatungstoeuropate displayed fine red luminescence at various temperatures and pH values, which could be utilized as a potential labeling material in field of medicine.
32818709	2	55	theme	luminescent	465:475	arg1	particles					497:505	the luminescent decatungstoeuropate particles	461:505	the luminescent decatungstoeuropate particles	461:505	To fabricate the nanocomposite, the mesoporous silica nanoparticles were coated with thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan and the luminescent decatungstoeuropate particles were grafted onto copolymers.
32942569	4	0	theme	mechanical	492:501	arg1	stress					503:508	mechanical stress	492:508	mechanical stress	492:508	The biofilm matrix is essential for biofilms to remain organized under mechanical stress.
32942569	9	1	theme	sub-lethal	1267:1276	arg1	doses					1278:1282	sub-lethal doses	1267:1282	sub-lethal doses of vitamin C	1267:1295	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	0	2	theme	Viscoelastic	78:89	arg1	Properties					91:100	the Viscoelastic Properties	74:100	the Viscoelastic Properties of Bacillus subtilis Biofilms	74:130	The Exo-Polysaccharide Component of Extracellular Matrix is Essential for the Viscoelastic Properties of Bacillus subtilis Biofilms.
32942569	10	3	theme	EPS	1440:1442	arg1	essential					1471:1479	essential	1471:1479	essential	1471:1479	In both cases, the obtained results suggest that the EPS component of the matrix is essential for maintaining the viscoelastic properties of bacterial biofilms during their growth.
32942569	10	3	theme	EPS	1440:1442	arg1	component					1444:1452	the EPS component	1436:1452	the EPS component of the matrix	1436:1466	In both cases, the obtained results suggest that the EPS component of the matrix is essential for maintaining the viscoelastic properties of bacterial biofilms during their growth.
32942569	1	4	from	biofilms	160:167	arg1	surfaces					180:187	various surfaces	172:187	various surfaces	172:187	Bacteria are known to form biofilms on various surfaces.
32942569	9	5	theme	biofilm	1225:1231	arg1	matrix					1233:1238	the biofilm matrix	1221:1238	the biofilm matrix	1221:1238	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	0	6	theme	Bacillus	105:112	arg1	Biofilms					123:130	Bacillus subtilis Biofilms	105:130	Bacillus subtilis Biofilms	105:130	The Exo-Polysaccharide Component of Extracellular Matrix is Essential for the Viscoelastic Properties of Bacillus subtilis Biofilms.
32942569	8	7	theme	interfacial	1019:1029	arg1	rheology					1031:1038	interfacial rheology	1019:1038	interfacial rheology	1019:1038	In this study, we used interfacial rheology to study the contribution of the EPS component of the matrix to viscoelasticity of Bacillus subtilis biofilms.
32942569	2	8	theme	biological	292:301	arg1	polymers					303:310	biological polymers	292:310	biological polymers	292:310	Biofilms are multicellular aggregates, held together by an extracellular matrix, which is composed of biological polymers.
32942569	11	9	theme	biofilms	1644:1651	arg1	stability					1631:1639	the mechanical stability	1616:1639	the mechanical stability of biofilms	1616:1651	If the EPS component of the matrix is depleted, the mechanical stability of biofilms is compromised and the biofilms become more susceptible to eradication by mechanical stress.
32942569	10	10	theme	obtained	1406:1413	arg1	results					1415:1421	the obtained results	1402:1421	the obtained results	1402:1421	In both cases, the obtained results suggest that the EPS component of the matrix is essential for maintaining the viscoelastic properties of bacterial biofilms during their growth.
32942569	6	11	theme	many	822:825	arg1	environments					827:838	many environments	822:838	many environments	822:838	Their viscoelastic properties, including during their growth dynamics, are crucial for biofilm survival in many environments, particularly during infection processes.
32942569	5	12	dep	exhibit	554:560	arg1	needs					661:665	needs	661:665	needs to take into account their viscoelastic nature	661:712	Thanks to their polymeric nature, biofilms exhibit both elastic and viscous mechanical characteristics; therefore, an accurate mechanical description needs to take into account their viscoelastic nature.
32942569	3	13	theme	matrix	355:360	arg1	components					329:338	Three principal components	313:338	Three principal components of the biofilm matrix	313:360	Three principal components of the biofilm matrix are exopolysaccharides (EPS), proteins, and nucleic acids.
32942569	3	13	theme	matrix	355:360	arg1	exopolysaccharides					366:383	exopolysaccharides	366:383	exopolysaccharides (EPS)	366:389	Three principal components of the biofilm matrix are exopolysaccharides (EPS), proteins, and nucleic acids.
32942569	8	14	theme	component	1077:1085	arg1	contribution					1053:1064	the contribution	1049:1064	the contribution of the EPS component of the matrix to viscoelasticity of Bacillus subtilis biofilms	1049:1148	In this study, we used interfacial rheology to study the contribution of the EPS component of the matrix to viscoelasticity of Bacillus subtilis biofilms.
32942569	0	15	dep	Bacillus	105:112	arg1	subtilis					114:121	subtilis	114:121	subtilis	114:121	The Exo-Polysaccharide Component of Extracellular Matrix is Essential for the Viscoelastic Properties of Bacillus subtilis Biofilms.
32942569	6	16	theme	viscoelastic	721:732	arg1	properties					734:743	Their viscoelastic properties	715:743	Their viscoelastic properties	715:743	Their viscoelastic properties, including during their growth dynamics, are crucial for biofilm survival in many environments, particularly during infection processes.
32942569	1	17	theme	various	172:178	arg1	surfaces					180:187	various surfaces	172:187	various surfaces	172:187	Bacteria are known to form biofilms on various surfaces.
32942569	9	18	theme	seamless	1306:1313	arg1	inactivation					1315:1326	seamless inactivation	1306:1326	(ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS	1301:1384	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	0	19	theme	Matrix	50:55	arg1	Component					23:31	The Exo-Polysaccharide Component	0:31	The Exo-Polysaccharide Component of Extracellular Matrix	0:55	The Exo-Polysaccharide Component of Extracellular Matrix is Essential for the Viscoelastic Properties of Bacillus subtilis Biofilms.
32942569	0	19	theme	Matrix	50:55	arg1	Essential					60:68	Essential	60:68	Essential	60:68	The Exo-Polysaccharide Component of Extracellular Matrix is Essential for the Viscoelastic Properties of Bacillus subtilis Biofilms.
32942569	5	20	theme	elastic	567:573	arg1	characteristics					598:612	both elastic and viscous mechanical characteristics	562:612	both elastic and viscous mechanical characteristics	562:612	Thanks to their polymeric nature, biofilms exhibit both elastic and viscous mechanical characteristics; therefore, an accurate mechanical description needs to take into account their viscoelastic nature.
32942569	9	21	dep	treatment	1252:1260	arg1	i					1249:1249	i	1249:1249	i	1249:1249	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	0	22	theme	Biofilms	123:130	arg1	Properties					91:100	the Viscoelastic Properties	74:100	the Viscoelastic Properties of Bacillus subtilis Biofilms	74:130	The Exo-Polysaccharide Component of Extracellular Matrix is Essential for the Viscoelastic Properties of Bacillus subtilis Biofilms.
32942569	0	23	theme	Exo-Polysaccharide	4:21	arg1	Component					23:31	The Exo-Polysaccharide Component	0:31	The Exo-Polysaccharide Component of Extracellular Matrix	0:55	The Exo-Polysaccharide Component of Extracellular Matrix is Essential for the Viscoelastic Properties of Bacillus subtilis Biofilms.
32942569	0	23	theme	Exo-Polysaccharide	4:21	arg1	Essential					60:68	Essential	60:68	Essential	60:68	The Exo-Polysaccharide Component of Extracellular Matrix is Essential for the Viscoelastic Properties of Bacillus subtilis Biofilms.
32942569	9	24	theme	operon	1339:1344	arg1	treatment					1252:1260	treatment	1252:1260	(i) treatment with sub-lethal doses of vitamin C	1248:1295	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	9	24	theme	operon	1339:1344	arg1	component					1208:1216	the EPS component	1200:1216	the EPS component of the biofilm matrix	1200:1238	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	9	24	theme	operon	1339:1344	arg1	inactivation					1315:1326	seamless inactivation	1306:1326	(ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS	1301:1384	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	5	25	theme	mechanical	638:647	arg1	description					649:659	an accurate mechanical description	626:659	an accurate mechanical description	626:659	Thanks to their polymeric nature, biofilms exhibit both elastic and viscous mechanical characteristics; therefore, an accurate mechanical description needs to take into account their viscoelastic nature.
32942569	6	26	theme	biofilm	802:808	arg1	survival					810:817	biofilm survival	802:817	biofilm survival in many environments	802:838	Their viscoelastic properties, including during their growth dynamics, are crucial for biofilm survival in many environments, particularly during infection processes.
32942569	8	27	theme	Bacillus	1123:1130	arg1	biofilms					1141:1148	Bacillus subtilis biofilms	1123:1148	Bacillus subtilis biofilms	1123:1148	In this study, we used interfacial rheology to study the contribution of the EPS component of the matrix to viscoelasticity of Bacillus subtilis biofilms.
32942569	5	28	theme	viscous	579:585	arg1	characteristics					598:612	both elastic and viscous mechanical characteristics	562:612	both elastic and viscous mechanical characteristics	562:612	Thanks to their polymeric nature, biofilms exhibit both elastic and viscous mechanical characteristics; therefore, an accurate mechanical description needs to take into account their viscoelastic nature.
32942569	5	29	theme	mechanical	587:596	arg1	characteristics					598:612	both elastic and viscous mechanical characteristics	562:612	both elastic and viscous mechanical characteristics	562:612	Thanks to their polymeric nature, biofilms exhibit both elastic and viscous mechanical characteristics; therefore, an accurate mechanical description needs to take into account their viscoelastic nature.
32942569	9	30	theme	EPS	1204:1206	arg1	component					1208:1216	the EPS component	1200:1216	the EPS component of the biofilm matrix	1200:1238	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	8	31	dep	Bacillus	1123:1130	arg1	subtilis					1132:1139	subtilis	1132:1139	subtilis	1132:1139	In this study, we used interfacial rheology to study the contribution of the EPS component of the matrix to viscoelasticity of Bacillus subtilis biofilms.
32942569	9	32	theme	eps	1335:1337	arg1	operon					1339:1344	the eps operon	1331:1344	the eps operon responsible for biosynthesis of the EPS	1331:1384	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	8	33	theme	matrix	1094:1099	arg1	component					1077:1085	the EPS component	1069:1085	the EPS component of the matrix	1069:1099	In this study, we used interfacial rheology to study the contribution of the EPS component of the matrix to viscoelasticity of Bacillus subtilis biofilms.
32942569	3	34	theme	nucleic	406:412	arg1	acids					414:418	nucleic acids	406:418	nucleic acids	406:418	Three principal components of the biofilm matrix are exopolysaccharides (EPS), proteins, and nucleic acids.
32942569	8	35	used	used	1014:1017	arg2	we					1011:1012	we	1011:1012	we	1011:1012	In this study, we used interfacial rheology to study the contribution of the EPS component of the matrix to viscoelasticity of Bacillus subtilis biofilms.
32942569	10	36	theme	matrix	1461:1466	arg1	essential					1471:1479	essential	1471:1479	essential	1471:1479	In both cases, the obtained results suggest that the EPS component of the matrix is essential for maintaining the viscoelastic properties of bacterial biofilms during their growth.
32942569	10	36	theme	matrix	1461:1466	arg1	component					1444:1452	the EPS component	1436:1452	the EPS component of the matrix	1436:1466	In both cases, the obtained results suggest that the EPS component of the matrix is essential for maintaining the viscoelastic properties of bacterial biofilms during their growth.
32942569	6	37	from	survival	810:817	arg1	environments					827:838	many environments	822:838	many environments	822:838	Their viscoelastic properties, including during their growth dynamics, are crucial for biofilm survival in many environments, particularly during infection processes.
32942569	0	38	theme	Extracellular	36:48	arg1	Matrix					50:55	Extracellular Matrix	36:55	Extracellular Matrix	36:55	The Exo-Polysaccharide Component of Extracellular Matrix is Essential for the Viscoelastic Properties of Bacillus subtilis Biofilms.
32942569	9	39	theme	responsible	1346:1356	arg1	operon					1339:1344	the eps operon	1331:1344	the eps operon responsible for biosynthesis of the EPS	1331:1384	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	11	40	theme	EPS	1575:1577	arg1	component					1579:1587	the EPS component	1571:1587	the EPS component of the matrix	1571:1601	If the EPS component of the matrix is depleted, the mechanical stability of biofilms is compromised and the biofilms become more susceptible to eradication by mechanical stress.
32942569	9	41	dep	inactivation	1315:1326	arg1	ii					1302:1303	ii	1302:1303	ii	1302:1303	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	10	42	theme	viscoelastic	1501:1512	arg1	properties					1514:1523	the viscoelastic properties	1497:1523	the viscoelastic properties of bacterial biofilms	1497:1545	In both cases, the obtained results suggest that the EPS component of the matrix is essential for maintaining the viscoelastic properties of bacterial biofilms during their growth.
32942569	10	43	theme	bacterial	1528:1536	arg1	biofilms					1538:1545	bacterial biofilms	1528:1545	bacterial biofilms	1528:1545	In both cases, the obtained results suggest that the EPS component of the matrix is essential for maintaining the viscoelastic properties of bacterial biofilms during their growth.
32942569	3	44	theme	principal	319:327	arg1	components					329:338	Three principal components	313:338	Three principal components of the biofilm matrix	313:360	Three principal components of the biofilm matrix are exopolysaccharides (EPS), proteins, and nucleic acids.
32942569	3	44	theme	principal	319:327	arg1	exopolysaccharides					366:383	exopolysaccharides	366:383	exopolysaccharides (EPS)	366:389	Three principal components of the biofilm matrix are exopolysaccharides (EPS), proteins, and nucleic acids.
32942569	5	45	theme	accurate	629:636	arg1	description					649:659	an accurate mechanical description	626:659	an accurate mechanical description	626:659	Thanks to their polymeric nature, biofilms exhibit both elastic and viscous mechanical characteristics; therefore, an accurate mechanical description needs to take into account their viscoelastic nature.
32942569	9	46	theme	C	1295:1295	arg1	doses					1278:1282	sub-lethal doses	1267:1282	sub-lethal doses of vitamin C	1267:1295	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	8	47	theme	EPS	1073:1075	arg1	component					1077:1085	the EPS component	1069:1085	the EPS component of the matrix	1069:1099	In this study, we used interfacial rheology to study the contribution of the EPS component of the matrix to viscoelasticity of Bacillus subtilis biofilms.
32942569	9	48	with	component	1208:1216	arg1	doses					1278:1282	sub-lethal doses	1267:1282	sub-lethal doses of vitamin C	1267:1295	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	5	49	theme	viscoelastic	694:705	arg1	nature					707:712	their viscoelastic nature	688:712	their viscoelastic nature	688:712	Thanks to their polymeric nature, biofilms exhibit both elastic and viscous mechanical characteristics; therefore, an accurate mechanical description needs to take into account their viscoelastic nature.
32942569	6	50	theme	infection	861:869	arg1	processes					871:879	infection processes	861:879	infection processes	861:879	Their viscoelastic properties, including during their growth dynamics, are crucial for biofilm survival in many environments, particularly during infection processes.
32942569	9	51	used	used	1171:1174	arg2	strategies					1155:1164	Two strategies	1151:1164	Two strategies	1151:1164	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	6	52	theme	growth	769:774	arg1	dynamics					776:783	their growth dynamics	763:783	their growth dynamics	763:783	Their viscoelastic properties, including during their growth dynamics, are crucial for biofilm survival in many environments, particularly during infection processes.
32942569	11	53	theme	mechanical	1620:1629	arg1	stability					1631:1639	the mechanical stability	1616:1639	the mechanical stability of biofilms	1616:1651	If the EPS component of the matrix is depleted, the mechanical stability of biofilms is compromised and the biofilms become more susceptible to eradication by mechanical stress.
32942569	9	54	with	inactivation	1315:1326	arg1	doses					1278:1282	sub-lethal doses	1267:1282	sub-lethal doses of vitamin C	1267:1295	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	11	55	theme	mechanical	1727:1736	arg1	stress					1738:1743	mechanical stress	1727:1743	mechanical stress	1727:1743	If the EPS component of the matrix is depleted, the mechanical stability of biofilms is compromised and the biofilms become more susceptible to eradication by mechanical stress.
32942569	8	56	theme	biofilms	1141:1148	arg1	viscoelasticity					1104:1118	viscoelasticity	1104:1118	viscoelasticity of Bacillus subtilis biofilms	1104:1148	In this study, we used interfacial rheology to study the contribution of the EPS component of the matrix to viscoelasticity of Bacillus subtilis biofilms.
32942569	2	57	theme	multicellular	203:215	arg1	Biofilms					190:197	Biofilms	190:197	Biofilms	190:197	Biofilms are multicellular aggregates, held together by an extracellular matrix, which is composed of biological polymers.
32942569	2	57	theme	multicellular	203:215	arg1	aggregates					217:226	multicellular aggregates	203:226	multicellular aggregates	203:226	Biofilms are multicellular aggregates, held together by an extracellular matrix, which is composed of biological polymers.
32942569	11	58	theme	matrix	1596:1601	arg1	component					1579:1587	the EPS component	1571:1587	the EPS component of the matrix	1571:1601	If the EPS component of the matrix is depleted, the mechanical stability of biofilms is compromised and the biofilms become more susceptible to eradication by mechanical stress.
32942569	9	59	with	treatment	1252:1260	arg1	doses					1278:1282	sub-lethal doses	1267:1282	sub-lethal doses of vitamin C	1267:1295	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	7	60	theme	biofilm	920:926	arg1	matrix					928:933	the biofilm matrix	916:933	the biofilm matrix	916:933	How changes in the composition of the biofilm matrix affect viscoelasticity has not been thoroughly investigated.
32942569	9	61	theme	EPS	1382:1384	arg1	biosynthesis					1362:1373	biosynthesis	1362:1373	biosynthesis of the EPS	1362:1384	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	10	62	theme	biofilms	1538:1545	arg1	properties					1514:1523	the viscoelastic properties	1497:1523	the viscoelastic properties of bacterial biofilms	1497:1545	In both cases, the obtained results suggest that the EPS component of the matrix is essential for maintaining the viscoelastic properties of bacterial biofilms during their growth.
32942569	4	63	theme	biofilm	425:431	arg1	essential					443:451	essential	443:451	essential	443:451	The biofilm matrix is essential for biofilms to remain organized under mechanical stress.
32942569	4	63	theme	biofilm	425:431	arg1	matrix					433:438	The biofilm matrix	421:438	The biofilm matrix	421:438	The biofilm matrix is essential for biofilms to remain organized under mechanical stress.
32942569	7	64	from	changes	886:892	arg1	composition					901:911	the composition	897:911	the composition of the biofilm matrix	897:933	How changes in the composition of the biofilm matrix affect viscoelasticity has not been thoroughly investigated.
32942569	7	65	theme	matrix	928:933	arg1	composition					901:911	the composition	897:911	the composition of the biofilm matrix	897:933	How changes in the composition of the biofilm matrix affect viscoelasticity has not been thoroughly investigated.
32942569	9	66	theme	matrix	1233:1238	arg1	treatment					1252:1260	treatment	1252:1260	(i) treatment with sub-lethal doses of vitamin C	1248:1295	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	9	66	theme	matrix	1233:1238	arg1	component					1208:1216	the EPS component	1200:1216	the EPS component of the biofilm matrix	1200:1238	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	9	66	theme	matrix	1233:1238	arg1	inactivation					1315:1326	seamless inactivation	1306:1326	(ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS	1301:1384	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	3	67	theme	biofilm	347:353	arg1	matrix					355:360	the biofilm matrix	343:360	the biofilm matrix	343:360	Three principal components of the biofilm matrix are exopolysaccharides (EPS), proteins, and nucleic acids.
32942569	9	68	theme	vitamin	1287:1293	arg1	C					1295:1295	vitamin C	1287:1295	vitamin C	1287:1295	Two strategies were used to specifically deplete the EPS component of the biofilm matrix, namely (i) treatment with sub-lethal doses of vitamin C and (ii) seamless inactivation of the eps operon responsible for biosynthesis of the EPS.
32942569	2	69	theme	extracellular	249:261	arg1	matrix					263:268	an extracellular matrix	246:268	an extracellular matrix	246:268	Biofilms are multicellular aggregates, held together by an extracellular matrix, which is composed of biological polymers.
32942569	5	70	theme	polymeric	527:535	arg1	nature					537:542	their polymeric nature	521:542	their polymeric nature	521:542	Thanks to their polymeric nature, biofilms exhibit both elastic and viscous mechanical characteristics; therefore, an accurate mechanical description needs to take into account their viscoelastic nature.
32599270	7	0	theme	MCC	1042:1044	arg1	pellets					1052:1058	MCC based pellets	1042:1058	MCC based pellets obtained with SDS	1042:1076	MCC based pellets obtained with SDS showed wider PSD and lower sphericity than those made with PL, K2HPO4 and their combinations.
32599270	1	1	from	impact	167:172	arg1	functionality					221:233	the functionality	217:233	the functionality of MCC	217:240	This study designed to investigate the impact of surface tension of moistening liquid on the functionality of MCC as pelletization aid.
32599270	1	2	theme	MCC	238:240	arg1	functionality					221:233	the functionality	217:233	the functionality of MCC	217:240	This study designed to investigate the impact of surface tension of moistening liquid on the functionality of MCC as pelletization aid.
32599270	7	3	theme	based	1046:1050	arg1	pellets					1052:1058	MCC based pellets	1042:1058	MCC based pellets obtained with SDS	1042:1076	MCC based pellets obtained with SDS showed wider PSD and lower sphericity than those made with PL, K2HPO4 and their combinations.
32599270	6	4	theme	tension	926:932	arg1	2.08-					973:977	2.08-	973:977	2.08-	973:977	In contrast, the surface tension values of PL and K2HPO4 solutions were 2.08- and 3.07-fold higher than that of SDS solutions, respectively.
32599270	6	4	theme	tension	926:932	arg1	values					934:939	the surface tension values	914:939	the surface tension values of PL and K2HPO4 solutions	914:966	In contrast, the surface tension values of PL and K2HPO4 solutions were 2.08- and 3.07-fold higher than that of SDS solutions, respectively.
32599270	0	5	theme	microcrystalline	79:94	arg1	cellulose					96:104	microcrystalline cellulose	79:104	microcrystalline cellulose	79:104	Influence of the surface tension of wet massing liquid on the functionality of microcrystalline cellulose as pelletization aid.
32599270	0	6	from	Influence	0:8	arg1	functionality					62:74	the functionality	58:74	the functionality of microcrystalline cellulose as pelletization	58:121	Influence of the surface tension of wet massing liquid on the functionality of microcrystalline cellulose as pelletization aid.
32599270	6	7	from	contrast	904:911	arg1	2.08-					973:977	2.08-	973:977	2.08-	973:977	In contrast, the surface tension values of PL and K2HPO4 solutions were 2.08- and 3.07-fold higher than that of SDS solutions, respectively.
32599270	6	7	from	contrast	904:911	arg1	values					934:939	the surface tension values	914:939	the surface tension values of PL and K2HPO4 solutions	914:966	In contrast, the surface tension values of PL and K2HPO4 solutions were 2.08- and 3.07-fold higher than that of SDS solutions, respectively.
32599270	6	8	theme	SDS	1013:1015	arg1	solutions					1017:1025	SDS solutions	1013:1025	SDS solutions	1013:1025	In contrast, the surface tension values of PL and K2HPO4 solutions were 2.08- and 3.07-fold higher than that of SDS solutions, respectively.
32599270	7	9	dep	wider	1085:1089	arg1	PSD					1091:1093	PSD	1091:1093	PSD	1091:1093	MCC based pellets obtained with SDS showed wider PSD and lower sphericity than those made with PL, K2HPO4 and their combinations.
32599270	7	9	dep	wider	1085:1089	arg1	sphericity					1105:1114	lower sphericity	1099:1114	lower sphericity	1099:1114	MCC based pellets obtained with SDS showed wider PSD and lower sphericity than those made with PL, K2HPO4 and their combinations.
32599270	9	10	theme	liquid	1340:1345	arg1	essential					1351:1359	essential	1351:1359	essential	1351:1359	It was thus inferred that a critical surface tension of moistening liquid was essential for functionality of MCC as pelletization aid but not for PM and Cop.
32599270	9	10	theme	liquid	1340:1345	arg1	tension					1318:1324	a critical surface tension	1299:1324	a critical surface tension of moistening liquid	1299:1345	It was thus inferred that a critical surface tension of moistening liquid was essential for functionality of MCC as pelletization aid but not for PM and Cop.
32599270	2	11	theme	dicalcium	459:467	arg1	DCP					480:482	DCP	480:482	DCP	480:482	For this purpose, sodium dodecyl sulfate (SDS), poloxamer 188 (PL), di-potassium hydrogen phosphate (K2HPO4) and combinations thereof were incorporated into the powder blend comprised of MCC and dicalcium phosphate (DCP) at different levels.
32599270	2	11	theme	dicalcium	459:467	arg1	phosphate					469:477	dicalcium phosphate	459:477	dicalcium phosphate (DCP)	459:483	For this purpose, sodium dodecyl sulfate (SDS), poloxamer 188 (PL), di-potassium hydrogen phosphate (K2HPO4) and combinations thereof were incorporated into the powder blend comprised of MCC and dicalcium phosphate (DCP) at different levels.
32599270	6	12	theme	surface	918:924	arg1	tension					926:932	surface tension	918:932	the surface tension values of PL and K2HPO4 solutions	914:966	In contrast, the surface tension values of PL and K2HPO4 solutions were 2.08- and 3.07-fold higher than that of SDS solutions, respectively.
32599270	4	13	theme	median	696:701	arg1	D50					713:715	D50	713:715	D50	713:715	The pellets prepared were characterized for their median diameter (D50), particle size distribution (PSD), sphericity, porosity, tensile strength and disintegration.
32599270	4	13	theme	median	696:701	arg1	diameter					703:710	their median diameter	690:710	their median diameter (D50)	690:716	The pellets prepared were characterized for their median diameter (D50), particle size distribution (PSD), sphericity, porosity, tensile strength and disintegration.
32599270	5	14	from	mN/m	881:884	arg1	drop					826:829	a drop	824:829	a drop in the surface tension of water from 68.7 to 23.7 mN/m	824:884	SDS induced a drop in the surface tension of water from 68.7 to 23.7 mN/m at 0.1% (w/w).
32599270	2	15	theme	hydrogen	345:352	arg1	K2HPO4					365:370	K2HPO4	365:370	K2HPO4	365:370	For this purpose, sodium dodecyl sulfate (SDS), poloxamer 188 (PL), di-potassium hydrogen phosphate (K2HPO4) and combinations thereof were incorporated into the powder blend comprised of MCC and dicalcium phosphate (DCP) at different levels.
32599270	2	15	theme	hydrogen	345:352	arg1	phosphate					354:362	di-potassium hydrogen phosphate	332:362	di-potassium hydrogen phosphate (K2HPO4)	332:371	For this purpose, sodium dodecyl sulfate (SDS), poloxamer 188 (PL), di-potassium hydrogen phosphate (K2HPO4) and combinations thereof were incorporated into the powder blend comprised of MCC and dicalcium phosphate (DCP) at different levels.
32599270	0	16	theme	cellulose	96:104	arg1	functionality					62:74	the functionality	58:74	the functionality of microcrystalline cellulose as pelletization	58:121	Influence of the surface tension of wet massing liquid on the functionality of microcrystalline cellulose as pelletization aid.
32599270	2	17	theme	di-potassium	332:343	arg1	K2HPO4					365:370	K2HPO4	365:370	K2HPO4	365:370	For this purpose, sodium dodecyl sulfate (SDS), poloxamer 188 (PL), di-potassium hydrogen phosphate (K2HPO4) and combinations thereof were incorporated into the powder blend comprised of MCC and dicalcium phosphate (DCP) at different levels.
32599270	2	17	theme	di-potassium	332:343	arg1	phosphate					354:362	di-potassium hydrogen phosphate	332:362	di-potassium hydrogen phosphate (K2HPO4)	332:371	For this purpose, sodium dodecyl sulfate (SDS), poloxamer 188 (PL), di-potassium hydrogen phosphate (K2HPO4) and combinations thereof were incorporated into the powder blend comprised of MCC and dicalcium phosphate (DCP) at different levels.
32599270	3	18	theme	pelletization	626:638	arg1	aids					640:643	pelletization aids	626:643	pelletization aids	626:643	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	19	theme	Physical	506:513	arg1	PM					524:525	PM	524:525	PM	524:525	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	19	theme	Physical	506:513	arg1	mixture					515:521	Physical mixture	506:521	Physical mixture (PM)	506:526	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	1	20	dep	pelletization	245:257	arg1	aid					259:261	aid	259:261	aid	259:261	This study designed to investigate the impact of surface tension of moistening liquid on the functionality of MCC as pelletization aid.
32599270	1	21	theme	surface	177:183	arg1	tension					185:191	surface tension	177:191	surface tension of moistening liquid	177:212	This study designed to investigate the impact of surface tension of moistening liquid on the functionality of MCC as pelletization aid.
32599270	0	22	theme	surface	17:23	arg1	tension					25:31	the surface tension	13:31	the surface tension of wet massing liquid	13:53	Influence of the surface tension of wet massing liquid on the functionality of microcrystalline cellulose as pelletization aid.
32599270	8	23	theme	concentration	1233:1245	arg1	rise					1221:1224	rise	1221:1224	rise of SDS concentration	1221:1245	In addition, the PSD and porosity increased with rise of SDS concentration from 0.05 to 0.25% (w/w).
32599270	2	24	theme	different	488:496	arg1	levels					498:503	different levels	488:503	different levels	488:503	For this purpose, sodium dodecyl sulfate (SDS), poloxamer 188 (PL), di-potassium hydrogen phosphate (K2HPO4) and combinations thereof were incorporated into the powder blend comprised of MCC and dicalcium phosphate (DCP) at different levels.
32599270	2	25	theme	sodium	282:287	arg1	SDS					306:308	SDS	306:308	SDS	306:308	For this purpose, sodium dodecyl sulfate (SDS), poloxamer 188 (PL), di-potassium hydrogen phosphate (K2HPO4) and combinations thereof were incorporated into the powder blend comprised of MCC and dicalcium phosphate (DCP) at different levels.
32599270	2	25	theme	sodium	282:287	arg1	sulfate					297:303	sodium dodecyl sulfate	282:303	sodium dodecyl sulfate (SDS)	282:309	For this purpose, sodium dodecyl sulfate (SDS), poloxamer 188 (PL), di-potassium hydrogen phosphate (K2HPO4) and combinations thereof were incorporated into the powder blend comprised of MCC and dicalcium phosphate (DCP) at different levels.
32599270	6	26	from	2.08-	973:977	arg1	contrast					904:911	contrast	904:911	contrast	904:911	In contrast, the surface tension values of PL and K2HPO4 solutions were 2.08- and 3.07-fold higher than that of SDS solutions, respectively.
32599270	1	27	theme	tension	185:191	arg1	impact					167:172	the impact	163:172	the impact of surface tension of moistening liquid on the functionality of MCC	163:240	This study designed to investigate the impact of surface tension of moistening liquid on the functionality of MCC as pelletization aid.
32599270	2	28	theme	dodecyl	289:295	arg1	SDS					306:308	SDS	306:308	SDS	306:308	For this purpose, sodium dodecyl sulfate (SDS), poloxamer 188 (PL), di-potassium hydrogen phosphate (K2HPO4) and combinations thereof were incorporated into the powder blend comprised of MCC and dicalcium phosphate (DCP) at different levels.
32599270	2	28	theme	dodecyl	289:295	arg1	sulfate					297:303	sodium dodecyl sulfate	282:303	sodium dodecyl sulfate (SDS)	282:309	For this purpose, sodium dodecyl sulfate (SDS), poloxamer 188 (PL), di-potassium hydrogen phosphate (K2HPO4) and combinations thereof were incorporated into the powder blend comprised of MCC and dicalcium phosphate (DCP) at different levels.
32599270	5	29	theme	water	857:861	arg1	tension					846:852	the surface tension	834:852	the surface tension of water	834:861	SDS induced a drop in the surface tension of water from 68.7 to 23.7 mN/m at 0.1% (w/w).
32599270	3	30	theme	MCC	564:566	arg1	MCC					564:566	MCC	564:566	MCC	564:566	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	30	theme	MCC	564:566	arg1	mixture					515:521	Physical mixture	506:521	Physical mixture (PM)	506:526	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	30	theme	MCC	564:566	arg1	composite					545:553	co-processed composite	532:553	co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC)	532:608	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	30	theme	MCC	564:566	arg1	Cop					556:558	Cop	556:558	Cop	556:558	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	30	theme	MCC	564:566	arg1	cellulose					593:601	sodium carboxymethyl cellulose	572:601	sodium carboxymethyl cellulose (SCMC)	572:608	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	30	theme	MCC	564:566	arg1	PM					524:525	PM	524:525	PM	524:525	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	5	31	theme	surface	838:844	arg1	tension					846:852	the surface tension	834:852	the surface tension of water	834:861	SDS induced a drop in the surface tension of water from 68.7 to 23.7 mN/m at 0.1% (w/w).
32599270	9	32	theme	critical	1301:1308	arg1	essential					1351:1359	essential	1351:1359	essential	1351:1359	It was thus inferred that a critical surface tension of moistening liquid was essential for functionality of MCC as pelletization aid but not for PM and Cop.
32599270	9	32	theme	critical	1301:1308	arg1	tension					1318:1324	a critical surface tension	1299:1324	a critical surface tension of moistening liquid	1299:1345	It was thus inferred that a critical surface tension of moistening liquid was essential for functionality of MCC as pelletization aid but not for PM and Cop.
32599270	2	33	theme	powder	425:430	arg1	blend					432:436	the powder blend	421:436	the powder blend comprised of MCC and dicalcium phosphate (DCP)	421:483	For this purpose, sodium dodecyl sulfate (SDS), poloxamer 188 (PL), di-potassium hydrogen phosphate (K2HPO4) and combinations thereof were incorporated into the powder blend comprised of MCC and dicalcium phosphate (DCP) at different levels.
32599270	4	34	theme	particle	719:726	arg1	PSD					747:749	PSD	747:749	PSD	747:749	The pellets prepared were characterized for their median diameter (D50), particle size distribution (PSD), sphericity, porosity, tensile strength and disintegration.
32599270	4	34	theme	particle	719:726	arg1	distribution					733:744	particle size distribution	719:744	particle size distribution (PSD)	719:750	The pellets prepared were characterized for their median diameter (D50), particle size distribution (PSD), sphericity, porosity, tensile strength and disintegration.
32599270	9	35	dep	pelletization	1389:1401	arg1	aid					1403:1405	aid	1403:1405	aid	1403:1405	It was thus inferred that a critical surface tension of moistening liquid was essential for functionality of MCC as pelletization aid but not for PM and Cop.
32599270	0	36	theme	tension	25:31	arg1	Influence					0:8	Influence	0:8	Influence of the surface tension of wet massing liquid on the functionality of microcrystalline cellulose as pelletization	0:121	Influence of the surface tension of wet massing liquid on the functionality of microcrystalline cellulose as pelletization aid.
32599270	8	37	dep	0.25	1260:1263	arg1	to					1257:1258	to	1257:1258	to	1257:1258	In addition, the PSD and porosity increased with rise of SDS concentration from 0.05 to 0.25% (w/w).
32599270	1	38	theme	liquid	207:212	arg1	tension					185:191	surface tension	177:191	surface tension of moistening liquid	177:212	This study designed to investigate the impact of surface tension of moistening liquid on the functionality of MCC as pelletization aid.
32599270	9	39	theme	MCC	1382:1384	arg1	functionality					1365:1377	functionality	1365:1377	functionality of MCC as pelletization aid	1365:1405	It was thus inferred that a critical surface tension of moistening liquid was essential for functionality of MCC as pelletization aid but not for PM and Cop.
32599270	7	40	theme	lower	1099:1103	arg1	sphericity					1105:1114	lower sphericity	1099:1114	lower sphericity	1099:1114	MCC based pellets obtained with SDS showed wider PSD and lower sphericity than those made with PL, K2HPO4 and their combinations.
32599270	4	41	theme	tensile	775:781	arg1	strength					783:790	tensile strength	775:790	tensile strength	775:790	The pellets prepared were characterized for their median diameter (D50), particle size distribution (PSD), sphericity, porosity, tensile strength and disintegration.
32599270	3	42	theme	cellulose	593:601	arg1	MCC					564:566	MCC	564:566	MCC	564:566	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	42	theme	cellulose	593:601	arg1	mixture					515:521	Physical mixture	506:521	Physical mixture (PM)	506:526	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	42	theme	cellulose	593:601	arg1	composite					545:553	co-processed composite	532:553	co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC)	532:608	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	42	theme	cellulose	593:601	arg1	Cop					556:558	Cop	556:558	Cop	556:558	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	42	theme	cellulose	593:601	arg1	cellulose					593:601	sodium carboxymethyl cellulose	572:601	sodium carboxymethyl cellulose (SCMC)	572:608	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	42	theme	cellulose	593:601	arg1	PM					524:525	PM	524:525	PM	524:525	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	4	43	theme	size	728:731	arg1	PSD					747:749	PSD	747:749	PSD	747:749	The pellets prepared were characterized for their median diameter (D50), particle size distribution (PSD), sphericity, porosity, tensile strength and disintegration.
32599270	4	43	theme	size	728:731	arg1	distribution					733:744	particle size distribution	719:744	particle size distribution (PSD)	719:750	The pellets prepared were characterized for their median diameter (D50), particle size distribution (PSD), sphericity, porosity, tensile strength and disintegration.
32599270	6	44	theme	solutions	958:966	arg1	2.08-					973:977	2.08-	973:977	2.08-	973:977	In contrast, the surface tension values of PL and K2HPO4 solutions were 2.08- and 3.07-fold higher than that of SDS solutions, respectively.
32599270	6	44	theme	solutions	958:966	arg1	values					934:939	the surface tension values	914:939	the surface tension values of PL and K2HPO4 solutions	914:966	In contrast, the surface tension values of PL and K2HPO4 solutions were 2.08- and 3.07-fold higher than that of SDS solutions, respectively.
32599270	6	45	theme	K2HPO4	951:956	arg1	solutions					958:966	PL and K2HPO4 solutions	944:966	PL and K2HPO4 solutions	944:966	In contrast, the surface tension values of PL and K2HPO4 solutions were 2.08- and 3.07-fold higher than that of SDS solutions, respectively.
32599270	3	46	theme	sodium	572:577	arg1	SCMC					604:607	SCMC	604:607	SCMC	604:607	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	46	theme	sodium	572:577	arg1	cellulose					593:601	sodium carboxymethyl cellulose	572:601	sodium carboxymethyl cellulose (SCMC)	572:608	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	9	47	theme	surface	1310:1316	arg1	essential					1351:1359	essential	1351:1359	essential	1351:1359	It was thus inferred that a critical surface tension of moistening liquid was essential for functionality of MCC as pelletization aid but not for PM and Cop.
32599270	9	47	theme	surface	1310:1316	arg1	tension					1318:1324	a critical surface tension	1299:1324	a critical surface tension of moistening liquid	1299:1345	It was thus inferred that a critical surface tension of moistening liquid was essential for functionality of MCC as pelletization aid but not for PM and Cop.
32599270	5	48	from	drop	826:829	arg1	tension					846:852	the surface tension	834:852	the surface tension of water	834:861	SDS induced a drop in the surface tension of water from 68.7 to 23.7 mN/m at 0.1% (w/w).
32599270	3	49	theme	carboxymethyl	579:591	arg1	SCMC					604:607	SCMC	604:607	SCMC	604:607	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	49	theme	carboxymethyl	579:591	arg1	cellulose					593:601	sodium carboxymethyl cellulose	572:601	sodium carboxymethyl cellulose (SCMC)	572:608	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	50	theme	co-processed	532:543	arg1	MCC					564:566	MCC	564:566	MCC	564:566	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	50	theme	co-processed	532:543	arg1	composite					545:553	co-processed composite	532:553	co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC)	532:608	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	50	theme	co-processed	532:543	arg1	cellulose					593:601	sodium carboxymethyl cellulose	572:601	sodium carboxymethyl cellulose (SCMC)	572:608	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	3	50	theme	co-processed	532:543	arg1	Cop					556:558	Cop	556:558	Cop	556:558	Physical mixture (PM) and co-processed composite (Cop) of MCC and sodium carboxymethyl cellulose (SCMC) replaced MCC as pelletization aids.
32599270	5	51	dep	23.7	876:879	arg1	to					873:874	to	873:874	to	873:874	SDS induced a drop in the surface tension of water from 68.7 to 23.7 mN/m at 0.1% (w/w).
32599270	6	52	theme	PL	944:945	arg1	solutions					958:966	PL and K2HPO4 solutions	944:966	PL and K2HPO4 solutions	944:966	In contrast, the surface tension values of PL and K2HPO4 solutions were 2.08- and 3.07-fold higher than that of SDS solutions, respectively.
32599270	0	53	theme	liquid	48:53	arg1	tension					25:31	the surface tension	13:31	the surface tension of wet massing liquid	13:53	Influence of the surface tension of wet massing liquid on the functionality of microcrystalline cellulose as pelletization aid.
32599270	8	54	theme	SDS	1229:1231	arg1	concentration					1233:1245	SDS concentration	1229:1245	SDS concentration	1229:1245	In addition, the PSD and porosity increased with rise of SDS concentration from 0.05 to 0.25% (w/w).
33647702	1	0	theme	identical	340:348	arg1	composition					350:360	identical composition	340:360	identical composition	340:360	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	6	1	theme	greater	1139:1145	arg1	efficiency					1147:1156	greater efficiency	1139:1156	greater efficiency	1139:1156	The coatings effectively inhibited microorganism growth, extending shelf-life by 2 days, single-layer coatings showing greater efficiency.
33647702	3	2	theme	Atlantic	538:545	arg1	mackerel					547:554	Atlantic mackerel	538:554	Atlantic mackerel (storage 4 °C, 15 days)	538:578	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	7	3	theme	attractiveness	1236:1249	arg1	parameters					1251:1260	product attractiveness parameters	1228:1260	product attractiveness parameters	1228:1260	According to consumers, coating application did not adversely affect product attractiveness parameters.
33647702	0	4	theme	antioxidant	83:93	arg1	peptide					95:101	antioxidant peptide	83:101	antioxidant peptide	83:101	One- and double-layered furcellaran/carp skin gelatin hydrolysate film system with antioxidant peptide as an innovative packaging for perishable foods products.
33647702	4	5	theme	carcass	761:767	arg1	perception					769:778	mackerel carcass perception	752:778	mackerel carcass perception	752:778	Consumer analysis was performed characterising mackerel carcass perception depending on implemented active coatings.
33647702	5	6	from	period	956:961	arg1	slow					893:896	slow	893:896	slow	893:896	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	5	6	from	period	956:961	arg1	conditions					1008:1017	refrigerated conditions	995:1017	refrigerated conditions	995:1017	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	4	7	theme	Consumer	705:712	arg1	analysis					714:721	Consumer analysis	705:721	Consumer analysis	705:721	Consumer analysis was performed characterising mackerel carcass perception depending on implemented active coatings.
33647702	8	8	theme	perishable	1360:1369	arg1	foods					1371:1375	perishable foods	1360:1375	perishable foods	1360:1375	The developed innovative coatings show great applicative potential as a new active packaging for perishable foods.
33647702	8	9	theme	innovative	1277:1286	arg1	coatings					1288:1295	The developed innovative coatings	1263:1295	The developed innovative coatings	1263:1295	The developed innovative coatings show great applicative potential as a new active packaging for perishable foods.
33647702	1	10	with	films	329:333	arg1	composition					350:360	identical composition	340:360	identical composition	340:360	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	4	11	theme	active	805:810	arg1	coatings					812:819	implemented active coatings	793:819	implemented active coatings	793:819	Consumer analysis was performed characterising mackerel carcass perception depending on implemented active coatings.
33647702	8	12	theme	active	1339:1344	arg1	packaging					1346:1354	a new active packaging	1333:1354	a new active packaging	1333:1354	The developed innovative coatings show great applicative potential as a new active packaging for perishable foods.
33647702	8	13	theme	developed	1267:1275	arg1	coatings					1288:1295	The developed innovative coatings	1263:1295	The developed innovative coatings	1263:1295	The developed innovative coatings show great applicative potential as a new active packaging for perishable foods.
33647702	4	14	theme	implemented	793:803	arg1	coatings					812:819	implemented active coatings	793:819	implemented active coatings	793:819	Consumer analysis was performed characterising mackerel carcass perception depending on implemented active coatings.
33647702	8	15	theme	applicative	1308:1318	arg1	potential					1320:1328	great applicative potential	1302:1328	great applicative potential as a new active packaging for perishable foods	1302:1375	The developed innovative coatings show great applicative potential as a new active packaging for perishable foods.
33647702	1	16	theme	synthetic	367:375	arg1	peptide					377:383	synthetic peptide	367:383	synthetic peptide	367:383	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	0	17	with	system	71:76	arg1	peptide					95:101	antioxidant peptide	83:101	antioxidant peptide	83:101	One- and double-layered furcellaran/carp skin gelatin hydrolysate film system with antioxidant peptide as an innovative packaging for perishable foods products.
33647702	6	18	theme	single-layer	1109:1120	arg1	2 days					1101:1106	2 days	1101:1106	2 days	1101:1106	The coatings effectively inhibited microorganism growth, extending shelf-life by 2 days, single-layer coatings showing greater efficiency.
33647702	6	18	theme	single-layer	1109:1120	arg1	coatings					1122:1129	single-layer coatings	1109:1129	single-layer coatings showing greater efficiency	1109:1156	The coatings effectively inhibited microorganism growth, extending shelf-life by 2 days, single-layer coatings showing greater efficiency.
33647702	5	19	theme	storage	984:990	arg1	period					956:961	the initial period	944:961	the initial period of Atlantic mackerel storage in refrigerated conditions	944:1017	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	2	20	theme	procedure	416:424	arg1	objective					426:434	The procedure objective	412:434	The procedure objective	412:434	The procedure objective was multiplying antioxidant effects of the hydrolysate complexed with furcellaran.
33647702	0	21	theme	innovative	109:118	arg1	packaging					120:128	an innovative packaging	106:128	an innovative packaging for perishable foods products	106:158	One- and double-layered furcellaran/carp skin gelatin hydrolysate film system with antioxidant peptide as an innovative packaging for perishable foods products.
33647702	5	22	from	storage	984:990	arg1	conditions					1008:1017	refrigerated conditions	995:1017	refrigerated conditions	995:1017	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	5	23	theme	double-layer	859:870	arg1	coatings					872:879	The developed innovative single- and double-layer coatings	822:879	The developed innovative single- and double-layer coatings	822:879	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	2	24	theme	hydrolysate	479:489	arg1	effects					464:470	antioxidant effects	452:470	antioxidant effects of the hydrolysate complexed with furcellaran	452:516	The procedure objective was multiplying antioxidant effects of the hydrolysate complexed with furcellaran.
33647702	1	25	theme	Alanina-Tyrosine	385:400	arg1	addition					402:409	Alanina-Tyrosine addition	385:409	Alanina-Tyrosine addition	385:409	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	5	26	theme	refrigerated	995:1006	arg1	conditions					1008:1017	refrigerated conditions	995:1017	refrigerated conditions	995:1017	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	1	27	dep	films	329:333	arg1	addition					402:409	Alanina-Tyrosine addition	385:409	Alanina-Tyrosine addition	385:409	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	1	28	theme	active	180:185	arg1	types					197:201	two active packaging types	176:201	two active packaging types	176:201	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	0	29	theme	One-	0:3	arg1	gelatin					46:52	One- and double-layered furcellaran/carp skin gelatin	0:52	One- and double-layered furcellaran/carp skin gelatin	0:52	One- and double-layered furcellaran/carp skin gelatin hydrolysate film system with antioxidant peptide as an innovative packaging for perishable foods products.
33647702	6	30	theme	microorganism	1055:1067	arg1	growth					1069:1074	microorganism growth	1055:1074	microorganism growth	1055:1074	The coatings effectively inhibited microorganism growth, extending shelf-life by 2 days, single-layer coatings showing greater efficiency.
33647702	7	31	theme	coating	1183:1189	arg1	application					1191:1201	coating application	1183:1201	coating application	1183:1201	According to consumers, coating application did not adversely affect product attractiveness parameters.
33647702	3	32	dep	mackerel	547:554	arg1	15 days					571:577	15 days	571:577	15 days	571:577	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	3	32	dep	mackerel	547:554	arg1	4 °C					565:568	storage 4 °C	557:568	storage 4 °C	557:568	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	1	33	theme	packaging	187:195	arg1	types					197:201	two active packaging types	176:201	two active packaging types	176:201	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	0	34	theme	furcellaran/carp	24:39	arg1	gelatin					46:52	One- and double-layered furcellaran/carp skin gelatin	0:52	One- and double-layered furcellaran/carp skin gelatin	0:52	One- and double-layered furcellaran/carp skin gelatin hydrolysate film system with antioxidant peptide as an innovative packaging for perishable foods products.
33647702	1	35	theme	carp	288:291	arg1	hydrolysate					306:316	a polysaccharide - furcellaran and carp skin gelatin hydrolysate	253:316	hydrolysate	306:316	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	0	36	theme	perishable	134:143	arg1	products					151:158	perishable foods products	134:158	perishable foods products	134:158	One- and double-layered furcellaran/carp skin gelatin hydrolysate film system with antioxidant peptide as an innovative packaging for perishable foods products.
33647702	3	37	from	changes	607:613	arg1	quality					634:640	microbiological quality	618:640	microbiological quality	618:640	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	2	38	theme	antioxidant	452:462	arg1	effects					464:470	antioxidant effects	452:470	antioxidant effects of the hydrolysate complexed with furcellaran	452:516	The procedure objective was multiplying antioxidant effects of the hydrolysate complexed with furcellaran.
33647702	0	39	theme	double-layered	9:22	arg1	gelatin					46:52	One- and double-layered furcellaran/carp skin gelatin	0:52	One- and double-layered furcellaran/carp skin gelatin	0:52	One- and double-layered furcellaran/carp skin gelatin hydrolysate film system with antioxidant peptide as an innovative packaging for perishable foods products.
33647702	1	40	theme	skin	293:296	arg1	hydrolysate					306:316	a polysaccharide - furcellaran and carp skin gelatin hydrolysate	253:316	hydrolysate	306:316	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	5	41	theme	down	898:901	arg1	processes					919:927	down lipid oxidation processes	898:927	down lipid oxidation processes	898:927	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	8	42	theme	new	1335:1337	arg1	packaging					1346:1354	a new active packaging	1333:1354	a new active packaging	1333:1354	The developed innovative coatings show great applicative potential as a new active packaging for perishable foods.
33647702	1	43	theme	gelatin	298:304	arg1	hydrolysate					306:316	a polysaccharide - furcellaran and carp skin gelatin hydrolysate	253:316	hydrolysate	306:316	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	5	44	theme	lipid	903:907	arg1	processes					919:927	down lipid oxidation processes	898:927	down lipid oxidation processes	898:927	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	0	45	theme	skin	41:44	arg1	gelatin					46:52	One- and double-layered furcellaran/carp skin gelatin	0:52	One- and double-layered furcellaran/carp skin gelatin	0:52	One- and double-layered furcellaran/carp skin gelatin hydrolysate film system with antioxidant peptide as an innovative packaging for perishable foods products.
33647702	0	46	theme	foods	145:149	arg1	products					151:158	perishable foods products	134:158	perishable foods products	134:158	One- and double-layered furcellaran/carp skin gelatin hydrolysate film system with antioxidant peptide as an innovative packaging for perishable foods products.
33647702	3	47	theme	biogenic	650:657	arg1	content					665:671	biogenic amine content	650:671	biogenic amine content	650:671	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	3	47	theme	biogenic	650:657	arg1	changes					607:613	changes	607:613	changes in microbiological quality	607:640	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	3	48	theme	microbiological	618:632	arg1	quality					634:640	microbiological quality	618:640	microbiological quality	618:640	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	5	49	theme	oxidation	909:917	arg1	processes					919:927	down lipid oxidation processes	898:927	down lipid oxidation processes	898:927	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	0	50	theme	film	66:69	arg1	system					71:76	film system	66:76	film system with antioxidant peptide	66:101	One- and double-layered furcellaran/carp skin gelatin hydrolysate film system with antioxidant peptide as an innovative packaging for perishable foods products.
33647702	3	51	theme	amine	659:663	arg1	content					665:671	biogenic amine content	650:671	biogenic amine content	650:671	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	3	51	theme	amine	659:663	arg1	changes					607:613	changes	607:613	changes in microbiological quality	607:640	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	5	52	theme	Atlantic	966:973	arg1	storage					984:990	Atlantic mackerel storage	966:990	Atlantic mackerel storage in refrigerated conditions	966:1017	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	5	53	theme	single-	847:853	arg1	coatings					872:879	The developed innovative single- and double-layer coatings	822:879	The developed innovative single- and double-layer coatings	822:879	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	1	54	theme	two-layer	319:327	arg1	films					329:333	two-layer films	319:333	two-layer films with identical composition	319:360	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	3	55	used	used	530:533	arg2	Films					519:523	Films	519:523	Films	519:523	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	5	56	theme	mackerel	975:982	arg1	storage					984:990	Atlantic mackerel storage	966:990	Atlantic mackerel storage in refrigerated conditions	966:1017	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	7	57	theme	product	1228:1234	arg1	parameters					1251:1260	product attractiveness parameters	1228:1260	product attractiveness parameters	1228:1260	According to consumers, coating application did not adversely affect product attractiveness parameters.
33647702	1	58	dep	produced	208:215	arg1	films					242:246	single-layer biopolymer films	218:246	single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate	218:316	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	1	58	dep	produced	208:215	arg1	peptide					377:383	synthetic peptide	367:383	synthetic peptide	367:383	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	1	58	dep	produced	208:215	arg1	films					329:333	two-layer films	319:333	two-layer films with identical composition	319:360	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	4	59	theme	mackerel	752:759	arg1	perception					769:778	mackerel carcass perception	752:778	mackerel carcass perception	752:778	Consumer analysis was performed characterising mackerel carcass perception depending on implemented active coatings.
33647702	1	60	theme	single-layer	218:229	arg1	films					242:246	single-layer biopolymer films	218:246	single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate	218:316	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	3	61	theme	fatty	674:678	arg1	composition					685:695	fatty acid composition	674:695	fatty acid composition	674:695	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	3	61	theme	fatty	674:678	arg1	changes					607:613	changes	607:613	changes in microbiological quality	607:640	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	8	62	theme	great	1302:1306	arg1	potential					1320:1328	great applicative potential	1302:1328	great applicative potential as a new active packaging for perishable foods	1302:1375	The developed innovative coatings show great applicative potential as a new active packaging for perishable foods.
33647702	1	63	with	films	242:246	arg1	polysaccharide					255:268	a polysaccharide - furcellaran and carp skin gelatin hydrolysate	253:316	polysaccharide	255:268	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	1	63	with	films	242:246	arg1	hydrolysate					306:316	a polysaccharide - furcellaran and carp skin gelatin hydrolysate	253:316	hydrolysate	306:316	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	1	63	with	films	242:246	arg1	furcellaran					272:282	a polysaccharide - furcellaran and carp skin gelatin hydrolysate	253:316	furcellaran	272:282	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	5	64	theme	initial	948:954	arg1	period					956:961	the initial period	944:961	the initial period of Atlantic mackerel storage in refrigerated conditions	944:1017	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	1	65	theme	biopolymer	231:240	arg1	films					242:246	single-layer biopolymer films	218:246	single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate	218:316	In this study, two active packaging types were produced: single-layer biopolymer films with a polysaccharide - furcellaran and carp skin gelatin hydrolysate; two-layer films with identical composition, but synthetic peptide Alanina-Tyrosine addition.
33647702	3	66	theme	acid	680:683	arg1	composition					685:695	fatty acid composition	674:695	fatty acid composition	674:695	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	3	66	theme	acid	680:683	arg1	changes					607:613	changes	607:613	changes in microbiological quality	607:640	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	5	67	from	conditions	1008:1017	arg1	period					956:961	the initial period	944:961	the initial period of Atlantic mackerel storage in refrigerated conditions	944:1017	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	5	68	theme	innovative	836:845	arg1	coatings					872:879	The developed innovative single- and double-layer coatings	822:879	The developed innovative single- and double-layer coatings	822:879	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	5	69	theme	developed	826:834	arg1	coatings					872:879	The developed innovative single- and double-layer coatings	822:879	The developed innovative single- and double-layer coatings	822:879	The developed innovative single- and double-layer coatings effectively slow down lipid oxidation processes, especially at the initial period of Atlantic mackerel storage in refrigerated conditions.
33647702	3	70	theme	storage	557:563	arg1	15 days					571:577	15 days	571:577	15 days	571:577	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33647702	3	70	theme	storage	557:563	arg1	4 °C					565:568	storage 4 °C	557:568	storage 4 °C	557:568	Films were used on Atlantic mackerel (storage 4 °C, 15 days); samples were analysed for changes in microbiological quality, TVB-N, biogenic amine content, fatty acid composition, TBARS.
33463340	3	0	theme	wound	491:495	arg1	dressing					497:504	wound dressing	491:504	wound dressing	491:504	In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG2000 via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability.
33463340	0	1	theme	Promoting	78:86	arg1	Properties					118:127	Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	33:127	Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	33:127	Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties Based on Collagen and Chitosan.
33463340	5	2	theme	new	888:890	arg1	perspective					892:902	a new perspective	886:902	a new perspective for the biomass-based hydrogels applied in medical field as wound dressing	886:977	This work offers a new perspective for the biomass-based hydrogels applied in medical field as wound dressing.
33463340	3	3	theme	pH	664:665	arg1	sensitivity					667:677	pH sensitivity	664:677	pH sensitivity	664:677	In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG2000 via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability.
33463340	3	4	theme	wound-healing	698:710	arg1	performance					712:722	wound-healing performance	698:722	wound-healing performance	698:722	In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG2000 via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability.
33463340	5	5	theme	wound	964:968	arg1	dressing					970:977	wound dressing	964:977	wound dressing	964:977	This work offers a new perspective for the biomass-based hydrogels applied in medical field as wound dressing.
33463340	1	6	theme	great	263:267	arg1	potential					269:277	their great potential	257:277	their great potential for application as biomaterials	257:309	Collagen (COL)-chitosan (CS) composite hydrogels are attracting increasing attention because of their great potential for application as biomaterials.
33463340	2	7	theme	linking	401:407	arg1	lack					376:379	lack	376:379	lack of fully reversible linking in their networks	376:425	However, conventional COL-CS hydrogels were easily disabled for lack of fully reversible linking in their networks.
33463340	0	8	theme	Hemostatic	107:116	arg1	Properties					118:127	Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	33:127	Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	33:127	Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties Based on Collagen and Chitosan.
33463340	4	9	theme	facial	827:832	arg1	expression					834:843	the facial expression	823:843	the facial expression via strain sensitivity	823:866	Furthermore, the hydrogel could monitor multiple human motions, especially the facial expression via strain sensitivity.
33463340	0	10	theme	Self-Healing	6:17	arg1	Hydrogel					19:26	Novel Self-Healing Hydrogel	0:26	Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	0:127	Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties Based on Collagen and Chitosan.
33463340	4	11	theme	strain	849:854	arg1	sensitivity					856:866	strain sensitivity	849:866	strain sensitivity	849:866	Furthermore, the hydrogel could monitor multiple human motions, especially the facial expression via strain sensitivity.
33463340	3	12	theme	dibenzaldehyde-modified	532:554	arg1	PEG2000					556:562	dibenzaldehyde-modified PEG2000	532:562	dibenzaldehyde-modified PEG2000	532:562	In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG2000 via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability.
33463340	1	13	theme	-chitosan	175:183	arg1	hydrogels					200:208	Collagen (COL)-chitosan (CS) composite hydrogels	161:208	Collagen (COL)-chitosan (CS) composite hydrogels	161:208	Collagen (COL)-chitosan (CS) composite hydrogels are attracting increasing attention because of their great potential for application as biomaterials.
33463340	0	14	theme	Novel	0:4	arg1	Hydrogel					19:26	Novel Self-Healing Hydrogel	0:26	Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	0:127	Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties Based on Collagen and Chitosan.
33463340	2	15	from	lack	376:379	arg1	networks					418:425	their networks	412:425	their networks	412:425	However, conventional COL-CS hydrogels were easily disabled for lack of fully reversible linking in their networks.
33463340	5	16	theme	medical	947:953	arg1	field					955:959	medical field	947:959	medical field	947:959	This work offers a new perspective for the biomass-based hydrogels applied in medical field as wound dressing.
33463340	1	17	dep	-chitosan	175:183	arg1	CS					186:187	CS	186:187	CS	186:187	Collagen (COL)-chitosan (CS) composite hydrogels are attracting increasing attention because of their great potential for application as biomaterials.
33463340	3	18	theme	good	621:624	arg1	stability					634:642	good thermal stability	621:642	good thermal stability	621:642	In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG2000 via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability.
33463340	3	19	theme	hemostatic	728:737	arg1	ability					739:745	hemostatic ability	728:745	hemostatic ability	728:745	In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG2000 via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability.
33463340	3	20	theme	thermal	626:632	arg1	stability					634:642	good thermal stability	621:642	good thermal stability	621:642	In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG2000 via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability.
33463340	3	21	theme	imine	576:580	arg1	bonds					582:586	dynamic imine bonds	568:586	dynamic imine bonds	568:586	In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG2000 via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability.
33463340	1	22	theme	composite	190:198	arg1	hydrogels					200:208	Collagen (COL)-chitosan (CS) composite hydrogels	161:208	Collagen (COL)-chitosan (CS) composite hydrogels	161:208	Collagen (COL)-chitosan (CS) composite hydrogels are attracting increasing attention because of their great potential for application as biomaterials.
33463340	0	23	theme	Injectable	33:42	arg1	Properties					118:127	Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	33:127	Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	33:127	Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties Based on Collagen and Chitosan.
33463340	0	24	with	Hydrogel	19:26	arg1	Properties					118:127	Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	33:127	Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	33:127	Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties Based on Collagen and Chitosan.
33463340	3	25	theme	hydrogel	478:485	arg1	kind					457:460	a kind	455:460	a kind	455:460	In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG2000 via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability.
33463340	0	26	theme	pH-Responsive	45:57	arg1	Properties					118:127	Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	33:127	Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	33:127	Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties Based on Collagen and Chitosan.
33463340	3	27	theme	dynamic	568:574	arg1	bonds					582:586	dynamic imine bonds	568:586	dynamic imine bonds	568:586	In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG2000 via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability.
33463340	2	28	theme	COL-CS	334:339	arg1	hydrogels					341:349	conventional COL-CS hydrogels	321:349	conventional COL-CS hydrogels	321:349	However, conventional COL-CS hydrogels were easily disabled for lack of fully reversible linking in their networks.
33463340	3	29	theme	COL/CS	597:602	arg1	hydrogels					604:612	the COL/CS hydrogels	593:612	the COL/CS hydrogels	593:612	In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG2000 via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability.
33463340	2	30	theme	conventional	321:332	arg1	hydrogels					341:349	conventional COL-CS hydrogels	321:349	conventional COL-CS hydrogels	321:349	However, conventional COL-CS hydrogels were easily disabled for lack of fully reversible linking in their networks.
33463340	5	31	theme	biomass-based	912:924	arg1	hydrogels					926:934	the biomass-based hydrogels	908:934	the biomass-based hydrogels applied in medical field as wound dressing	908:977	This work offers a new perspective for the biomass-based hydrogels applied in medical field as wound dressing.
33463340	4	32	theme	human	797:801	arg1	motions					803:809	multiple human motions	788:809	multiple human motions	788:809	Furthermore, the hydrogel could monitor multiple human motions, especially the facial expression via strain sensitivity.
33463340	3	33	theme	self-healing	465:476	arg1	hydrogel					478:485	self-healing hydrogel	465:485	self-healing hydrogel for wound dressing	465:504	In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG2000 via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability.
33463340	1	34	theme	increasing	225:234	arg1	attention					236:244	increasing attention	225:244	increasing attention	225:244	Collagen (COL)-chitosan (CS) composite hydrogels are attracting increasing attention because of their great potential for application as biomaterials.
33463340	0	35	theme	Strain-Sensitive	60:75	arg1	Properties					118:127	Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	33:127	Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties	33:127	Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties Based on Collagen and Chitosan.
33463340	4	36	theme	multiple	788:795	arg1	motions					803:809	multiple human motions	788:809	multiple human motions	788:809	Furthermore, the hydrogel could monitor multiple human motions, especially the facial expression via strain sensitivity.
33297112	1	0	theme	hydrothermal	307:318	arg1	method					320:325	the simple hydrothermal method	296:325	the simple hydrothermal method	296:325	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	3	1	theme	synergistic	485:495	arg1	reaction					497:504	the synergistic reaction	481:504	the synergistic reaction	481:504	Adsorption played a leading role in the synergistic reaction.
33297112	6	2	theme	pH	945:946	arg1	value					948:952	the optimal pH value	933:952	the optimal pH value of 6.0	933:959	The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6.
33297112	6	3	theme	Cu	1023:1024	arg1	adsorption					1009:1018	the adsorption	1005:1018	the adsorption of Cu(II) by MCTS-Ag/Bi2WO6	1005:1046	The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6.
33297112	6	4	theme	optimal	937:943	arg1	value					948:952	the optimal pH value	933:952	the optimal pH value of 6.0	933:959	The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6.
33297112	0	5	theme	magnetic	79:86	arg1	tungstate					106:114	a novel magnetic chitosan@ bismuth tungstate	71:114	a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite	71:158	Enhanced adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater by a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite.
33297112	0	6	theme	novel	73:77	arg1	tungstate					106:114	a novel magnetic chitosan@ bismuth tungstate	71:114	a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite	71:158	Enhanced adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater by a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite.
33297112	0	7	theme	@	96:96	arg1	tungstate					106:114	a novel magnetic chitosan@ bismuth tungstate	71:114	a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite	71:158	Enhanced adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater by a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite.
33297112	6	8	theme	Cu	855:856	arg1	capacity					843:850	the theoretical maximum adsorption capacity	808:850	the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g)	808:873	The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6.
33297112	8	9	theme	kinetic	1202:1208	arg1	model					1210:1214	pseudo-second-order kinetic model	1182:1214	pseudo-second-order kinetic model	1182:1214	The copper ion adsorption fitted well with pseudo-second-order kinetic model and its isotherm followed Freundlich model.
33297112	6	10	with	irradiation	916:926	arg1	value					948:952	the optimal pH value	933:952	the optimal pH value of 6.0	933:959	The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6.
33297112	8	11	theme	copper	1143:1148	arg1	adsorption					1154:1163	The copper ion adsorption	1139:1163	The copper ion adsorption	1139:1163	The copper ion adsorption fitted well with pseudo-second-order kinetic model and its isotherm followed Freundlich model.
33297112	0	12	theme	chitosan	88:95	arg1	tungstate					106:114	a novel magnetic chitosan@ bismuth tungstate	71:114	a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite	71:158	Enhanced adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater by a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite.
33297112	4	13	dep	transform	551:559	arg1	infrared					561:568	infrared	561:568	transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscope (SEM)	551:653	The catalysts were characterized by fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscope (SEM).
33297112	4	14	theme	X-ray	592:596	arg1	diffraction					598:608	X-ray diffraction	592:608	X-ray diffraction (XRD)	592:614	The catalysts were characterized by fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscope (SEM).
33297112	4	14	theme	X-ray	592:596	arg1	XRD					611:613	XRD	611:613	XRD	611:613	The catalysts were characterized by fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscope (SEM).
33297112	2	15	theme	adsorption/photocatalytic	380:404	arg1	removal					406:412	excellent adsorption/photocatalytic removal	370:412	excellent adsorption/photocatalytic removal of Cu(II)	370:422	Moreover, the MCTS-Ag/Bi2WO6 demonstrated excellent adsorption/photocatalytic removal of Cu(II) in aqueous solution.
33297112	0	16	theme	adsorption/photocatalytic	9:33	arg1	removal					35:41	adsorption/photocatalytic removal	9:41	adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater	9:66	Enhanced adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater by a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite.
33297112	4	17	dep	fourier	543:549	arg1	transform					551:559	transform	551:559	transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscope (SEM)	551:653	The catalysts were characterized by fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscope (SEM).
33297112	2	18	theme	excellent	370:378	arg1	removal					406:412	excellent adsorption/photocatalytic removal	370:412	excellent adsorption/photocatalytic removal of Cu(II)	370:422	Moreover, the MCTS-Ag/Bi2WO6 demonstrated excellent adsorption/photocatalytic removal of Cu(II) in aqueous solution.
33297112	2	19	theme	aqueous	427:433	arg1	solution					435:442	aqueous solution	427:442	aqueous solution	427:442	Moreover, the MCTS-Ag/Bi2WO6 demonstrated excellent adsorption/photocatalytic removal of Cu(II) in aqueous solution.
33297112	6	20	theme	experimental	775:786	arg1	results					788:794	The experimental results	771:794	The experimental results	771:794	The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6.
33297112	1	21	theme	easily	164:169	arg1	composite					182:190	An easily separation composite	161:190	An easily separation composite	161:190	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	1	21	theme	easily	164:169	arg1	tungstate					219:227	magnetic chitosan@bismuth tungstate	193:227	magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6)	193:261	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	7	22	theme	desirable	1084:1092	arg1	ability					1105:1111	desirable adsorption ability	1084:1111	desirable adsorption ability of Cu(II)	1084:1121	Meanwhile, the composite exhibited desirable adsorption ability of Cu(II) after 5 cycles.
33297112	6	23	theme	light	910:914	arg1	irradiation					916:926	simulated solar light irradiation	894:926	simulated solar light irradiation with the optimal pH value of 6.0	894:959	The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6.
33297112	1	24	theme	separation	171:180	arg1	composite					182:190	An easily separation composite	161:190	An easily separation composite	161:190	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	1	24	theme	separation	171:180	arg1	tungstate					219:227	magnetic chitosan@bismuth tungstate	193:227	magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6)	193:261	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	7	25	theme	adsorption	1094:1103	arg1	ability					1105:1111	desirable adsorption ability	1084:1111	desirable adsorption ability of Cu(II)	1084:1121	Meanwhile, the composite exhibited desirable adsorption ability of Cu(II) after 5 cycles.
33297112	6	26	theme	solar	904:908	arg1	irradiation					916:926	simulated solar light irradiation	894:926	simulated solar light irradiation with the optimal pH value of 6.0	894:959	The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6.
33297112	0	27	theme	bismuth	98:104	arg1	tungstate					106:114	a novel magnetic chitosan@ bismuth tungstate	71:114	a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite	71:158	Enhanced adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater by a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite.
33297112	6	28	theme	adsorption	832:841	arg1	capacity					843:850	the theoretical maximum adsorption capacity	808:850	the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g)	808:873	The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6.
33297112	8	29	theme	Freundlich	1242:1251	arg1	model					1253:1257	Freundlich model	1242:1257	Freundlich model	1242:1257	The copper ion adsorption fitted well with pseudo-second-order kinetic model and its isotherm followed Freundlich model.
33297112	6	30	theme	simulated	894:902	arg1	irradiation					916:926	simulated solar light irradiation	894:926	simulated solar light irradiation with the optimal pH value of 6.0	894:959	The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6.
33297112	5	31	theme	Cu	685:686	arg1	adsorption					671:680	adsorption	671:680	adsorption of Cu(II)	671:690	The effects on adsorption of Cu(II) were investigated, which included illumination, pH, and initial concentration.
33297112	4	32	theme	electron	629:636	arg1	SEM					650:652	SEM	650:652	SEM	650:652	The catalysts were characterized by fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscope (SEM).
33297112	4	32	theme	electron	629:636	arg1	microscope					638:647	scanning electron microscope	620:647	scanning electron microscope (SEM)	620:653	The catalysts were characterized by fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscope (SEM).
33297112	8	33	theme	ion	1150:1152	arg1	adsorption					1154:1163	The copper ion adsorption	1139:1163	The copper ion adsorption	1139:1163	The copper ion adsorption fitted well with pseudo-second-order kinetic model and its isotherm followed Freundlich model.
33297112	2	34	theme	Cu	417:418	arg1	removal					406:412	excellent adsorption/photocatalytic removal	370:412	excellent adsorption/photocatalytic removal of Cu(II)	370:422	Moreover, the MCTS-Ag/Bi2WO6 demonstrated excellent adsorption/photocatalytic removal of Cu(II) in aqueous solution.
33297112	0	35	theme	Cu	46:47	arg1	removal					35:41	adsorption/photocatalytic removal	9:41	adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater	9:66	Enhanced adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater by a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite.
33297112	0	36	from	wastewater	57:66	arg1	removal					35:41	adsorption/photocatalytic removal	9:41	adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater	9:66	Enhanced adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater by a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite.
33297112	1	37	theme	magnetic	193:200	arg1	composite					182:190	An easily separation composite	161:190	An easily separation composite	161:190	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	1	37	theme	magnetic	193:200	arg1	tungstate					219:227	magnetic chitosan@bismuth tungstate	193:227	magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6)	193:261	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	0	38	theme	silver	126:131	arg1	composite					150:158	silver (MCTS-Ag/Bi2WO6) composite	126:158	silver (MCTS-Ag/Bi2WO6) composite	126:158	Enhanced adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater by a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite.
33297112	6	39	theme	theoretical	812:822	arg1	capacity					843:850	the theoretical maximum adsorption capacity	808:850	the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g)	808:873	The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6.
33297112	8	40	theme	pseudo-second-order	1182:1200	arg1	model					1210:1214	pseudo-second-order kinetic model	1182:1214	pseudo-second-order kinetic model	1182:1214	The copper ion adsorption fitted well with pseudo-second-order kinetic model and its isotherm followed Freundlich model.
33297112	6	41	theme	6.0	957:959	arg1	value					948:952	the optimal pH value	933:952	the optimal pH value of 6.0	933:959	The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6.
33297112	3	42	theme	leading	465:471	arg1	role					473:476	a leading role	463:476	a leading role	463:476	Adsorption played a leading role in the synergistic reaction.
33297112	5	43	from	effects	660:666	arg1	adsorption					671:680	adsorption	671:680	adsorption of Cu(II)	671:690	The effects on adsorption of Cu(II) were investigated, which included illumination, pH, and initial concentration.
33297112	1	44	theme	chitosan	202:209	arg1	composite					182:190	An easily separation composite	161:190	An easily separation composite	161:190	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	1	44	theme	chitosan	202:209	arg1	tungstate					219:227	magnetic chitosan@bismuth tungstate	193:227	magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6)	193:261	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	0	45	theme	MCTS-Ag/Bi2WO6	134:147	arg1	composite					150:158	silver (MCTS-Ag/Bi2WO6) composite	126:158	silver (MCTS-Ag/Bi2WO6) composite	126:158	Enhanced adsorption/photocatalytic removal of Cu(Ⅱ) from wastewater by a novel magnetic chitosan@ bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6) composite.
33297112	1	46	theme	@	210:210	arg1	composite					182:190	An easily separation composite	161:190	An easily separation composite	161:190	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	1	46	theme	@	210:210	arg1	tungstate					219:227	magnetic chitosan@bismuth tungstate	193:227	magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6)	193:261	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	6	47	theme	maximum	824:830	arg1	capacity					843:850	the theoretical maximum adsorption capacity	808:850	the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g)	808:873	The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6.
33297112	4	48	theme	scanning	620:627	arg1	SEM					650:652	SEM	650:652	SEM	650:652	The catalysts were characterized by fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscope (SEM).
33297112	4	48	theme	scanning	620:627	arg1	microscope					638:647	scanning electron microscope	620:647	scanning electron microscope (SEM)	620:653	The catalysts were characterized by fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscope (SEM).
33297112	1	49	theme	bismuth	211:217	arg1	composite					182:190	An easily separation composite	161:190	An easily separation composite	161:190	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	1	49	theme	bismuth	211:217	arg1	tungstate					219:227	magnetic chitosan@bismuth tungstate	193:227	magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6)	193:261	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	7	50	theme	Cu	1116:1117	arg1	ability					1105:1111	desirable adsorption ability	1084:1111	desirable adsorption ability of Cu(II)	1084:1121	Meanwhile, the composite exhibited desirable adsorption ability of Cu(II) after 5 cycles.
33297112	1	51	theme	simple	300:305	arg1	method					320:325	the simple hydrothermal method	296:325	the simple hydrothermal method	296:325	An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method.
33297112	5	52	theme	initial	748:754	arg1	concentration					756:768	initial concentration	748:768	initial concentration	748:768	The effects on adsorption of Cu(II) were investigated, which included illumination, pH, and initial concentration.
32708063	3	0	theme	white	708:712	arg1	rabbits					714:720	New Zealand white rabbits	696:720	New Zealand white rabbits	696:720	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	4	1	theme	HDL	867:869	arg1	phospholipids					871:883	HDL phospholipids	867:883	HDL phospholipids	867:883	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	4	2	from	increases	834:842	arg1	cholesterol					768:778	plasma cholesterol	761:778	plasma cholesterol	761:778	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	4	2	from	increases	834:842	arg1	cholesterol					851:861	HDL cholesterol	847:861	HDL cholesterol	847:861	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	4	2	from	increases	834:842	arg1	phospholipids					871:883	HDL phospholipids	867:883	HDL phospholipids	867:883	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	4	2	from	increases	834:842	arg1	sphingomyelin					808:820	non-HDL sphingomyelin	800:820	non-HDL sphingomyelin	800:820	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	4	2	from	increases	834:842	arg1	triglycerides					781:793	triglycerides	781:793	triglycerides	781:793	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	2	3	theme	beneficial	359:368	arg1	related					397:403	related	397:403	related	397:403	However, it remains unclear whether the beneficial effects of pomegranate are related to improvement in the lipid components of HDL.
32708063	2	3	theme	beneficial	359:368	arg1	effects					370:376	the beneficial effects	355:376	the beneficial effects of pomegranate	355:391	However, it remains unclear whether the beneficial effects of pomegranate are related to improvement in the lipid components of HDL.
32708063	1	4	theme	high-density	250:261	arg1	lipoproteins					263:274	high-density lipoproteins	250:274	high-density lipoproteins (HDL) lipid composition	250:298	Previous studies demonstrated that pomegranate, which is a source of several bioactive molecules, induces modifications of high-density lipoproteins (HDL) lipid composition and functionality.
32708063	1	4	theme	high-density	250:261	arg1	HDL					277:279	HDL	277:279	HDL	277:279	Previous studies demonstrated that pomegranate, which is a source of several bioactive molecules, induces modifications of high-density lipoproteins (HDL) lipid composition and functionality.
32708063	7	5	theme	increased	1413:1421	arg1	resistance					1423:1432	an increased resistance	1410:1432	an increased resistance of HDL to oxidation	1410:1452	The modification on the lipid content after the supplementation was associated with an increased resistance of HDL to oxidation as determined by the conjugated dienes formation catalyzed by Cu2+.
32708063	9	6	theme	increasing	1704:1713	arg1	doses					1715:1719	increasing doses	1704:1719	increasing doses of acetylcholine of aorta rings co-incubated with the lipoproteins in an isolated organ bath	1704:1812	The effect of HDL on endothelial function was analyzed by the response to increasing doses of acetylcholine of aorta rings co-incubated with the lipoproteins in an isolated organ bath.
32708063	11	7	from	effect	1944:1949	arg1	function					1973:1980	endothelial function	1961:1980	endothelial function	1961:1980	In contrast, the negative effect of HDL on endothelial function was reverted by MiPo supplementation.
32708063	1	8	theme	lipoproteins	263:274	arg1	composition					288:298	high-density lipoproteins (HDL) lipid composition	250:298	high-density lipoproteins (HDL) lipid composition	250:298	Previous studies demonstrated that pomegranate, which is a source of several bioactive molecules, induces modifications of high-density lipoproteins (HDL) lipid composition and functionality.
32708063	10	9	theme	endothelium-dependent	1882:1902	arg1	vasodilation					1904:1915	the endothelium-dependent vasodilation	1878:1915	the endothelium-dependent vasodilation	1878:1915	The HDL from rabbits that received placebo partially inhibited the endothelium-dependent vasodilation.
32708063	3	10	theme	New	696:698	arg1	rabbits					714:720	New Zealand white rabbits	696:720	New Zealand white rabbits	696:720	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	12	11	theme	triglycerides	2196:2208	arg1	content					2185:2191	the content	2181:2191	the content of triglycerides	2181:2208	These results show that the beneficial effects of pomegranate are mediated at least in part by improving the functionality of HDL, probably via the reduction of the content of triglycerides in these lipoproteins.
32708063	5	12	theme	subclasses	967:976	arg1	triglycerides					937:949	the triglycerides	933:949	the triglycerides of the five HDL subclasses isolated by electrophoresis	933:1004	Concomitantly, the triglycerides of the five HDL subclasses isolated by electrophoresis significantly decreased, whereas phospholipids, cholesterol, and sphingomyelin of HDL subclasses, as well as the HDL size distribution remained unchanged.
32708063	9	13	theme	HDL	1644:1646	arg1	effect					1634:1639	The effect	1630:1639	The effect of HDL on endothelial function	1630:1670	The effect of HDL on endothelial function was analyzed by the response to increasing doses of acetylcholine of aorta rings co-incubated with the lipoproteins in an isolated organ bath.
32708063	12	14	theme	pomegranate	2070:2080	arg1	effects					2059:2065	the beneficial effects	2044:2065	the beneficial effects of pomegranate	2044:2080	These results show that the beneficial effects of pomegranate are mediated at least in part by improving the functionality of HDL, probably via the reduction of the content of triglycerides in these lipoproteins.
32708063	4	15	theme	plasma	761:766	arg1	cholesterol					768:778	plasma cholesterol	761:778	plasma cholesterol	761:778	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	3	16	theme	HDL	548:550	arg1	subclasses					552:561	HDL subclasses	548:561	HDL subclasses	548:561	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	9	17	theme	organ	1803:1807	arg1	bath					1809:1812	an isolated organ bath	1791:1812	an isolated organ bath	1791:1812	The effect of HDL on endothelial function was analyzed by the response to increasing doses of acetylcholine of aorta rings co-incubated with the lipoproteins in an isolated organ bath.
32708063	0	18	theme	Zealand	110:116	arg1	Rabbits					118:124	New Zealand Rabbits	106:124	New Zealand Rabbits	106:124	Microencapsulated Pomegranate Modifies the Composition and Function of High-Density Lipoproteins (HDL) in New Zealand Rabbits.
32708063	0	19	from	Function	59:66	arg1	Rabbits					118:124	New Zealand Rabbits	106:124	New Zealand Rabbits	106:124	Microencapsulated Pomegranate Modifies the Composition and Function of High-Density Lipoproteins (HDL) in New Zealand Rabbits.
32708063	6	20	theme	MiPo	1304:1307	arg1	supplementation					1309:1323	MiPo supplementation	1304:1323	MiPo supplementation	1304:1323	Of particular interest, the triglycerides content of HDL, estimated by the triglycerides-to-phospholipids ratio, decreased significantly after MiPo supplementation.
32708063	3	21	theme	lipid	527:531	arg1	composition					533:543	lipid composition	527:543	lipid composition	527:543	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	0	22	theme	New	106:108	arg1	Rabbits					118:124	New Zealand Rabbits	106:124	New Zealand Rabbits	106:124	Microencapsulated Pomegranate Modifies the Composition and Function of High-Density Lipoproteins (HDL) in New Zealand Rabbits.
32708063	5	23	theme	HDL	1119:1121	arg1	distribution					1128:1139	the HDL size distribution	1115:1139	the HDL size distribution	1115:1139	Concomitantly, the triglycerides of the five HDL subclasses isolated by electrophoresis significantly decreased, whereas phospholipids, cholesterol, and sphingomyelin of HDL subclasses, as well as the HDL size distribution remained unchanged.
32708063	3	24	dep	microencapsulated	668:684	arg1	pomegranate					656:666	a pomegranate	654:666	a pomegranate microencapsulated (MiPo) in New Zealand white rabbits	654:720	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	3	24	dep	microencapsulated	668:684	arg1	MiPo					687:690	MiPo	687:690	MiPo	687:690	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	6	25	theme	particular	1164:1173	arg1	interest					1175:1182	particular interest	1164:1182	particular interest	1164:1182	Of particular interest, the triglycerides content of HDL, estimated by the triglycerides-to-phospholipids ratio, decreased significantly after MiPo supplementation.
32708063	0	26	theme	Microencapsulated	0:16	arg1	Pomegranate					18:28	Microencapsulated Pomegranate	0:28	Microencapsulated Pomegranate	0:28	Microencapsulated Pomegranate Modifies the Composition and Function of High-Density Lipoproteins (HDL) in New Zealand Rabbits.
32708063	12	27	theme	content	2185:2191	arg1	reduction					2168:2176	the reduction	2164:2176	the reduction of the content of triglycerides in these lipoproteins	2164:2230	These results show that the beneficial effects of pomegranate are mediated at least in part by improving the functionality of HDL, probably via the reduction of the content of triglycerides in these lipoproteins.
32708063	12	28	theme	beneficial	2048:2057	arg1	effects					2059:2065	the beneficial effects	2044:2065	the beneficial effects of pomegranate	2044:2080	These results show that the beneficial effects of pomegranate are mediated at least in part by improving the functionality of HDL, probably via the reduction of the content of triglycerides in these lipoproteins.
32708063	0	29	from	Composition	43:53	arg1	Rabbits					118:124	New Zealand Rabbits	106:124	New Zealand Rabbits	106:124	Microencapsulated Pomegranate Modifies the Composition and Function of High-Density Lipoproteins (HDL) in New Zealand Rabbits.
32708063	9	30	theme	aorta	1741:1745	arg1	rings					1747:1751	aorta rings	1741:1751	aorta rings co-incubated with the lipoproteins in an isolated organ bath	1741:1812	The effect of HDL on endothelial function was analyzed by the response to increasing doses of acetylcholine of aorta rings co-incubated with the lipoproteins in an isolated organ bath.
32708063	4	31	from	decrease	749:756	arg1	cholesterol					768:778	plasma cholesterol	761:778	plasma cholesterol	761:778	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	4	31	from	decrease	749:756	arg1	cholesterol					851:861	HDL cholesterol	847:861	HDL cholesterol	847:861	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	4	31	from	decrease	749:756	arg1	phospholipids					871:883	HDL phospholipids	867:883	HDL phospholipids	867:883	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	4	31	from	decrease	749:756	arg1	sphingomyelin					808:820	non-HDL sphingomyelin	800:820	non-HDL sphingomyelin	800:820	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	4	31	from	decrease	749:756	arg1	triglycerides					781:793	triglycerides	781:793	triglycerides	781:793	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	4	32	theme	significant	737:747	arg1	decrease					749:756	a significant decrease	735:756	a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin	735:820	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	11	33	theme	endothelial	1961:1971	arg1	function					1973:1980	endothelial function	1961:1980	endothelial function	1961:1980	In contrast, the negative effect of HDL on endothelial function was reverted by MiPo supplementation.
32708063	2	34	theme	HDL	447:449	arg1	components					433:442	the lipid components	423:442	the lipid components of HDL	423:449	However, it remains unclear whether the beneficial effects of pomegranate are related to improvement in the lipid components of HDL.
32708063	4	35	theme	HDL	847:849	arg1	cholesterol					851:861	HDL cholesterol	847:861	HDL cholesterol	847:861	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	12	36	from	reduction	2168:2176	arg1	lipoproteins					2219:2230	these lipoproteins	2213:2230	these lipoproteins	2213:2230	These results show that the beneficial effects of pomegranate are mediated at least in part by improving the functionality of HDL, probably via the reduction of the content of triglycerides in these lipoproteins.
32708063	9	37	theme	acetylcholine	1724:1736	arg1	doses					1715:1719	increasing doses	1704:1719	increasing doses of acetylcholine of aorta rings co-incubated with the lipoproteins in an isolated organ bath	1704:1812	The effect of HDL on endothelial function was analyzed by the response to increasing doses of acetylcholine of aorta rings co-incubated with the lipoproteins in an isolated organ bath.
32708063	3	38	with	supplementation	633:647	arg1	pomegranate					656:666	a pomegranate	654:666	a pomegranate microencapsulated (MiPo) in New Zealand white rabbits	654:720	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	3	38	with	supplementation	633:647	arg1	MiPo					687:690	MiPo	687:690	MiPo	687:690	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	2	39	theme	pomegranate	381:391	arg1	related					397:403	related	397:403	related	397:403	However, it remains unclear whether the beneficial effects of pomegranate are related to improvement in the lipid components of HDL.
32708063	2	39	theme	pomegranate	381:391	arg1	effects					370:376	the beneficial effects	355:376	the beneficial effects of pomegranate	355:391	However, it remains unclear whether the beneficial effects of pomegranate are related to improvement in the lipid components of HDL.
32708063	1	40	theme	lipid	282:286	arg1	composition					288:298	high-density lipoproteins (HDL) lipid composition	250:298	high-density lipoproteins (HDL) lipid composition	250:298	Previous studies demonstrated that pomegranate, which is a source of several bioactive molecules, induces modifications of high-density lipoproteins (HDL) lipid composition and functionality.
32708063	9	41	from	effect	1634:1639	arg1	function					1663:1670	endothelial function	1651:1670	endothelial function	1651:1670	The effect of HDL on endothelial function was analyzed by the response to increasing doses of acetylcholine of aorta rings co-incubated with the lipoproteins in an isolated organ bath.
32708063	7	42	from	modification	1330:1341	arg1	content					1356:1362	the lipid content	1346:1362	the lipid content after the supplementation	1346:1388	The modification on the lipid content after the supplementation was associated with an increased resistance of HDL to oxidation as determined by the conjugated dienes formation catalyzed by Cu2+.
32708063	3	43	theme	subclasses	552:561	arg1	size					518:521	size	518:521	size	518:521	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	3	43	theme	subclasses	552:561	arg1	composition					533:543	lipid composition	527:543	lipid composition	527:543	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	2	44	theme	lipid	427:431	arg1	components					433:442	the lipid components	423:442	the lipid components of HDL	423:449	However, it remains unclear whether the beneficial effects of pomegranate are related to improvement in the lipid components of HDL.
32708063	1	45	theme	composition	288:298	arg1	modifications					233:245	modifications	233:245	modifications of high-density lipoproteins (HDL) lipid composition and functionality	233:316	Previous studies demonstrated that pomegranate, which is a source of several bioactive molecules, induces modifications of high-density lipoproteins (HDL) lipid composition and functionality.
32708063	6	46	theme	triglycerides	1189:1201	arg1	content					1203:1209	the triglycerides content	1185:1209	the triglycerides content	1185:1209	Of particular interest, the triglycerides content of HDL, estimated by the triglycerides-to-phospholipids ratio, decreased significantly after MiPo supplementation.
32708063	5	47	theme	subclasses	1092:1101	arg1	distribution					1128:1139	the HDL size distribution	1115:1139	the HDL size distribution	1115:1139	Concomitantly, the triglycerides of the five HDL subclasses isolated by electrophoresis significantly decreased, whereas phospholipids, cholesterol, and sphingomyelin of HDL subclasses, as well as the HDL size distribution remained unchanged.
32708063	5	47	theme	subclasses	1092:1101	arg1	cholesterol					1054:1064	cholesterol	1054:1064	cholesterol	1054:1064	Concomitantly, the triglycerides of the five HDL subclasses isolated by electrophoresis significantly decreased, whereas phospholipids, cholesterol, and sphingomyelin of HDL subclasses, as well as the HDL size distribution remained unchanged.
32708063	5	47	theme	subclasses	1092:1101	arg1	sphingomyelin					1071:1083	sphingomyelin	1071:1083	sphingomyelin of HDL subclasses	1071:1101	Concomitantly, the triglycerides of the five HDL subclasses isolated by electrophoresis significantly decreased, whereas phospholipids, cholesterol, and sphingomyelin of HDL subclasses, as well as the HDL size distribution remained unchanged.
32708063	5	47	theme	subclasses	1092:1101	arg1	phospholipids					1039:1051	phospholipids	1039:1051	phospholipids	1039:1051	Concomitantly, the triglycerides of the five HDL subclasses isolated by electrophoresis significantly decreased, whereas phospholipids, cholesterol, and sphingomyelin of HDL subclasses, as well as the HDL size distribution remained unchanged.
32708063	5	48	theme	HDL	963:965	arg1	subclasses					967:976	the five HDL subclasses	954:976	the five HDL subclasses isolated by electrophoresis	954:1004	Concomitantly, the triglycerides of the five HDL subclasses isolated by electrophoresis significantly decreased, whereas phospholipids, cholesterol, and sphingomyelin of HDL subclasses, as well as the HDL size distribution remained unchanged.
32708063	1	49	theme	several	196:202	arg1	molecules					214:222	several bioactive molecules	196:222	several bioactive molecules	196:222	Previous studies demonstrated that pomegranate, which is a source of several bioactive molecules, induces modifications of high-density lipoproteins (HDL) lipid composition and functionality.
32708063	12	50	theme	HDL	2146:2148	arg1	functionality					2129:2141	the functionality	2125:2141	the functionality of HDL	2125:2148	These results show that the beneficial effects of pomegranate are mediated at least in part by improving the functionality of HDL, probably via the reduction of the content of triglycerides in these lipoproteins.
32708063	9	51	theme	rings	1747:1751	arg1	acetylcholine					1724:1736	acetylcholine	1724:1736	acetylcholine of aorta rings co-incubated with the lipoproteins in an isolated organ bath	1724:1812	The effect of HDL on endothelial function was analyzed by the response to increasing doses of acetylcholine of aorta rings co-incubated with the lipoproteins in an isolated organ bath.
32708063	8	52	theme	paraoxonase-1	1535:1547	arg1	activity					1556:1563	paraoxonase-1 (PON1) activity	1535:1563	paraoxonase-1 (PON1) activity determined with phenylacetate as substrate	1535:1606	Accordingly, paraoxonase-1 (PON1) activity determined with phenylacetate as substrate increased after MiPo.
32708063	7	53	theme	HDL	1437:1439	arg1	resistance					1423:1432	an increased resistance	1410:1432	an increased resistance of HDL to oxidation	1410:1452	The modification on the lipid content after the supplementation was associated with an increased resistance of HDL to oxidation as determined by the conjugated dienes formation catalyzed by Cu2+.
32708063	4	54	with	supplementation	891:905	arg1	MiPo					912:915	MiPo	912:915	MiPo	912:915	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	1	55	theme	bioactive	204:212	arg1	molecules					214:222	several bioactive molecules	196:222	several bioactive molecules	196:222	Previous studies demonstrated that pomegranate, which is a source of several bioactive molecules, induces modifications of high-density lipoproteins (HDL) lipid composition and functionality.
32708063	1	56	theme	functionality	304:316	arg1	modifications					233:245	modifications	233:245	modifications of high-density lipoproteins (HDL) lipid composition and functionality	233:316	Previous studies demonstrated that pomegranate, which is a source of several bioactive molecules, induces modifications of high-density lipoproteins (HDL) lipid composition and functionality.
32708063	9	57	from	lipoproteins	1775:1786	arg1	bath					1809:1812	an isolated organ bath	1791:1812	an isolated organ bath	1791:1812	The effect of HDL on endothelial function was analyzed by the response to increasing doses of acetylcholine of aorta rings co-incubated with the lipoproteins in an isolated organ bath.
32708063	3	58	theme	supplementation	633:647	arg1	days					625:628	30 days	622:628	30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits	622:720	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	3	59	theme	lipoproteins	603:614	arg1	functionality					580:592	the functionality	576:592	the functionality of these lipoproteins	576:614	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	1	60	theme	molecules	214:222	arg1	source					186:191	a source	184:191	a source of several bioactive molecules	184:222	Previous studies demonstrated that pomegranate, which is a source of several bioactive molecules, induces modifications of high-density lipoproteins (HDL) lipid composition and functionality.
32708063	1	60	theme	molecules	214:222	arg1	pomegranate					162:172	pomegranate	162:172	pomegranate	162:172	Previous studies demonstrated that pomegranate, which is a source of several bioactive molecules, induces modifications of high-density lipoproteins (HDL) lipid composition and functionality.
32708063	11	61	theme	HDL	1954:1956	arg1	effect					1944:1949	the negative effect	1931:1949	the negative effect of HDL on endothelial function	1931:1980	In contrast, the negative effect of HDL on endothelial function was reverted by MiPo supplementation.
32708063	6	62	theme	triglycerides-to-phospholipids	1236:1265	arg1	ratio					1267:1271	the triglycerides-to-phospholipids ratio	1232:1271	the triglycerides-to-phospholipids ratio	1232:1271	Of particular interest, the triglycerides content of HDL, estimated by the triglycerides-to-phospholipids ratio, decreased significantly after MiPo supplementation.
32708063	5	63	theme	size	1123:1126	arg1	distribution					1128:1139	the HDL size distribution	1115:1139	the HDL size distribution	1115:1139	Concomitantly, the triglycerides of the five HDL subclasses isolated by electrophoresis significantly decreased, whereas phospholipids, cholesterol, and sphingomyelin of HDL subclasses, as well as the HDL size distribution remained unchanged.
32708063	0	64	dep	Composition	43:53	arg1	the					39:41	the	39:41	the	39:41	Microencapsulated Pomegranate Modifies the Composition and Function of High-Density Lipoproteins (HDL) in New Zealand Rabbits.
32708063	11	65	theme	negative	1935:1942	arg1	effect					1944:1949	the negative effect	1931:1949	the negative effect of HDL on endothelial function	1931:1980	In contrast, the negative effect of HDL on endothelial function was reverted by MiPo supplementation.
32708063	6	66	theme	HDL	1214:1216	arg1	content					1203:1209	the triglycerides content	1185:1209	the triglycerides content	1185:1209	Of particular interest, the triglycerides content of HDL, estimated by the triglycerides-to-phospholipids ratio, decreased significantly after MiPo supplementation.
32708063	9	67	theme	isolated	1794:1801	arg1	bath					1809:1812	an isolated organ bath	1791:1812	an isolated organ bath	1791:1812	The effect of HDL on endothelial function was analyzed by the response to increasing doses of acetylcholine of aorta rings co-incubated with the lipoproteins in an isolated organ bath.
32708063	9	68	theme	endothelial	1651:1661	arg1	function					1663:1670	endothelial function	1651:1670	endothelial function	1651:1670	The effect of HDL on endothelial function was analyzed by the response to increasing doses of acetylcholine of aorta rings co-incubated with the lipoproteins in an isolated organ bath.
32708063	1	69	theme	Previous	127:134	arg1	studies					136:142	Previous studies	127:142	Previous studies	127:142	Previous studies demonstrated that pomegranate, which is a source of several bioactive molecules, induces modifications of high-density lipoproteins (HDL) lipid composition and functionality.
32708063	3	70	dep	size	518:521	arg1	the					514:516	the	514:516	the	514:516	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	5	71	dep	decreased	1020:1028	arg1	whereas					1031:1037	whereas	1031:1037	whereas	1031:1037	Concomitantly, the triglycerides of the five HDL subclasses isolated by electrophoresis significantly decreased, whereas phospholipids, cholesterol, and sphingomyelin of HDL subclasses, as well as the HDL size distribution remained unchanged.
32708063	7	72	theme	conjugated	1475:1484	arg1	formation					1493:1501	the conjugated dienes formation	1471:1501	the conjugated dienes formation catalyzed by Cu2+	1471:1519	The modification on the lipid content after the supplementation was associated with an increased resistance of HDL to oxidation as determined by the conjugated dienes formation catalyzed by Cu2+.
32708063	7	73	theme	dienes	1486:1491	arg1	formation					1493:1501	the conjugated dienes formation	1471:1501	the conjugated dienes formation catalyzed by Cu2+	1471:1519	The modification on the lipid content after the supplementation was associated with an increased resistance of HDL to oxidation as determined by the conjugated dienes formation catalyzed by Cu2+.
32708063	3	74	theme	placebo-controlled	471:488	arg1	study					490:494	this placebo-controlled study	466:494	this placebo-controlled study	466:494	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	0	75	theme	Lipoproteins	84:95	arg1	Function					59:66	Function	59:66	Function	59:66	Microencapsulated Pomegranate Modifies the Composition and Function of High-Density Lipoproteins (HDL) in New Zealand Rabbits.
32708063	0	75	theme	Lipoproteins	84:95	arg1	Composition					43:53	Composition	43:53	Composition	43:53	Microencapsulated Pomegranate Modifies the Composition and Function of High-Density Lipoproteins (HDL) in New Zealand Rabbits.
32708063	5	76	theme	HDL	1088:1090	arg1	subclasses					1092:1101	HDL subclasses	1088:1101	HDL subclasses	1088:1101	Concomitantly, the triglycerides of the five HDL subclasses isolated by electrophoresis significantly decreased, whereas phospholipids, cholesterol, and sphingomyelin of HDL subclasses, as well as the HDL size distribution remained unchanged.
32708063	2	77	from	improvement	408:418	arg1	components					433:442	the lipid components	423:442	the lipid components of HDL	423:449	However, it remains unclear whether the beneficial effects of pomegranate are related to improvement in the lipid components of HDL.
32708063	11	78	theme	MiPo	1998:2001	arg1	supplementation					2003:2017	MiPo supplementation	1998:2017	MiPo supplementation	1998:2017	In contrast, the negative effect of HDL on endothelial function was reverted by MiPo supplementation.
32708063	7	79	theme	lipid	1350:1354	arg1	content					1356:1362	the lipid content	1346:1362	the lipid content after the supplementation	1346:1388	The modification on the lipid content after the supplementation was associated with an increased resistance of HDL to oxidation as determined by the conjugated dienes formation catalyzed by Cu2+.
32708063	0	80	theme	High-Density	71:82	arg1	HDL					98:100	HDL	98:100	HDL	98:100	Microencapsulated Pomegranate Modifies the Composition and Function of High-Density Lipoproteins (HDL) in New Zealand Rabbits.
32708063	0	80	theme	High-Density	71:82	arg1	Lipoproteins					84:95	High-Density Lipoproteins	71:95	High-Density Lipoproteins (HDL)	71:101	Microencapsulated Pomegranate Modifies the Composition and Function of High-Density Lipoproteins (HDL) in New Zealand Rabbits.
32708063	3	81	theme	Zealand	700:706	arg1	rabbits					714:720	New Zealand white rabbits	696:720	New Zealand white rabbits	696:720	Therefore, in this placebo-controlled study, we characterized the size and lipid composition of HDL subclasses and assessed the functionality of these lipoproteins after 30 days of supplementation with a pomegranate microencapsulated (MiPo) in New Zealand white rabbits.
32708063	4	82	theme	non-HDL	800:806	arg1	sphingomyelin					808:820	non-HDL sphingomyelin	800:820	non-HDL sphingomyelin	800:820	We observed a significant decrease in plasma cholesterol, triglycerides, and non-HDL sphingomyelin, as well as increases in HDL cholesterol and HDL phospholipids after supplementation with MiPo.
32708063	10	83	from	rabbits	1828:1834	arg1	HDL					1819:1821	The HDL	1815:1821	The HDL from rabbits that received placebo	1815:1856	The HDL from rabbits that received placebo partially inhibited the endothelium-dependent vasodilation.
34299652	8	0	theme	CS-based	1496:1503	arg1	surfaces					1505:1512	CS-based surfaces	1496:1512	CS-based surfaces	1496:1512	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	8	1	theme	structure	1581:1589	arg1	analysis					1591:1598	biofilm structure analysis	1573:1598	biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA	1573:1763	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	1	2	theme	clinical	255:262	arg1	complications					264:276	several clinical complications	247:276	several clinical complications	247:276	Implantable medical devices (IMDs) are susceptible to microbial adhesion and biofilm formation, which lead to several clinical complications, including the occurrence of implant-associated infections.
34299652	1	2	theme	clinical	255:262	arg1	occurrence					293:302	the occurrence	289:302	the occurrence of implant-associated infections	289:335	Implantable medical devices (IMDs) are susceptible to microbial adhesion and biofilm formation, which lead to several clinical complications, including the occurrence of implant-associated infections.
34299652	5	3	theme	PLA	866:868	arg1	films					870:874	PLA films	866:874	PLA films	866:874	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	5	4	theme	derivatives	849:859	arg1	presence					826:833	the presence	822:833	the presence of CS and its derivatives onto PLA films, as well surface homogeneity	822:903	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	8	5	theme	confocal	1606:1613	arg1	microscopy					1630:1639	confocal laser scanning microscopy	1606:1639	confocal laser scanning microscopy (CLSM)	1606:1646	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	8	5	theme	confocal	1606:1613	arg1	CLSM					1642:1645	CLSM	1642:1645	CLSM	1642:1645	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	5	6	theme	contact	923:929	arg1	Fourier					951:957	Fourier	951:957	Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM)	951:1035	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	5	6	theme	contact	923:929	arg1	measurements					937:948	contact angle measurements	923:948	contact angle measurements	923:948	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	6	7	theme	aureus	1170:1175	arg1	biofilms					1143:1150	single- and dual-species biofilms	1118:1150	single- and dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa	1118:1202	The antimicrobial activity of the functionalized surfaces was evaluated against single- and dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	8	8	from	thickness	1696:1704	arg1	biovolume					1682:1690	the biovolume	1678:1690	the biovolume	1678:1690	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	6	9	theme	aeruginosa	1193:1202	arg1	biofilms					1143:1150	single- and dual-species biofilms	1118:1150	single- and dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa	1118:1202	The antimicrobial activity of the functionalized surfaces was evaluated against single- and dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	7	10	theme	biofilms	1294:1301	arg1	development					1254:1264	the development	1250:1264	the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively	1250:1432	Chitosan-based surfaces were able to inhibit the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively, being their activity dependent on chitosan Mw.
34299652	6	11	theme	surfaces	1087:1094	arg1	activity					1056:1063	The antimicrobial activity	1038:1063	The antimicrobial activity of the functionalized surfaces	1038:1094	The antimicrobial activity of the functionalized surfaces was evaluated against single- and dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	7	12	theme	dependent	1456:1464	arg1	activity					1447:1454	their activity	1441:1454	their activity dependent on chitosan Mw	1441:1479	Chitosan-based surfaces were able to inhibit the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively, being their activity dependent on chitosan Mw.
34299652	0	13	theme	aureus	102:107	arg1	Single-					50:56	Single-	50:56	Single-	50:56	Development of Chitosan-Based Surfaces to Prevent Single- and Dual-Species Biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	0	13	theme	aureus	102:107	arg1	Biofilms					75:82	Dual-Species Biofilms	62:82	Dual-Species Biofilms	62:82	Development of Chitosan-Based Surfaces to Prevent Single- and Dual-Species Biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	9	14	theme	common	1901:1906	arg1	bacteria					1881:1888	the two bacteria	1873:1888	the two bacteria tested	1873:1895	Overall, these results support the potential of low Mw CS for coating polymeric devices such as IMDs where the two bacteria tested are common colonizers and reduce their biofilm formation.
34299652	9	14	theme	common	1901:1906	arg1	colonizers					1908:1917	common colonizers	1901:1917	common colonizers	1901:1917	Overall, these results support the potential of low Mw CS for coating polymeric devices such as IMDs where the two bacteria tested are common colonizers and reduce their biofilm formation.
34299652	6	15	theme	dual-species	1130:1141	arg1	biofilms					1143:1150	single- and dual-species biofilms	1118:1150	single- and dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa	1118:1202	The antimicrobial activity of the functionalized surfaces was evaluated against single- and dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	3	16	theme	due	523:525	arg1	field					517:521	the medical field	505:521	the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw)	505:622	In addition, chitosan (CS) is a natural polymer that has been widely used in the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw).
34299652	8	17	theme	scanning	1621:1628	arg1	microscopy					1630:1639	confocal laser scanning microscopy	1606:1639	confocal laser scanning microscopy (CLSM)	1606:1646	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	8	17	theme	scanning	1621:1628	arg1	CLSM					1642:1645	CLSM	1642:1645	CLSM	1642:1645	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	8	18	theme	biofilm	1535:1541	arg1	formation					1543:1551	biofilm formation	1535:1551	biofilm formation	1535:1551	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	0	19	theme	aeruginosa	125:134	arg1	Single-					50:56	Single-	50:56	Single-	50:56	Development of Chitosan-Based Surfaces to Prevent Single- and Dual-Species Biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	0	19	theme	aeruginosa	125:134	arg1	Biofilms					75:82	Dual-Species Biofilms	62:82	Dual-Species Biofilms	62:82	Development of Chitosan-Based Surfaces to Prevent Single- and Dual-Species Biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	9	20	theme	Mw	1818:1819	arg1	CS					1821:1822	low Mw CS	1814:1822	low Mw CS	1814:1822	Overall, these results support the potential of low Mw CS for coating polymeric devices such as IMDs where the two bacteria tested are common colonizers and reduce their biofilm formation.
34299652	5	21	dep	Fourier	951:957	arg1	transform					959:967	transform	959:967	transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM)	959:1035	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	4	22	theme	biofilm	734:740	arg1	formation					742:750	bacterial biofilm formation	724:750	bacterial biofilm formation	724:750	The present study aims to evaluate the performance of CS-based surfaces of different Mw to inhibit bacterial biofilm formation.
34299652	4	23	theme	present	629:635	arg1	study					637:641	The present study	625:641	The present study	625:641	The present study aims to evaluate the performance of CS-based surfaces of different Mw to inhibit bacterial biofilm formation.
34299652	7	24	theme	chitosan	1469:1476	arg1	Mw					1478:1479	chitosan Mw	1469:1479	chitosan Mw	1469:1479	Chitosan-based surfaces were able to inhibit the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively, being their activity dependent on chitosan Mw.
34299652	8	25	theme	CS-based	1731:1738	arg1	surfaces					1740:1747	CS-based surfaces	1731:1747	CS-based surfaces	1731:1747	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	3	26	theme	medical	509:515	arg1	field					517:521	the medical field	505:521	the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw)	505:622	In addition, chitosan (CS) is a natural polymer that has been widely used in the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw).
34299652	8	27	from	decrease	1666:1673	arg1	biovolume					1682:1690	the biovolume	1678:1690	the biovolume	1678:1690	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	9	28	theme	biofilm	1936:1942	arg1	formation					1944:1952	their biofilm formation	1930:1952	their biofilm formation	1930:1952	Overall, these results support the potential of low Mw CS for coating polymeric devices such as IMDs where the two bacteria tested are common colonizers and reduce their biofilm formation.
34299652	3	29	from	polymer	468:474	arg1	addition					431:438	addition	431:438	addition	431:438	In addition, chitosan (CS) is a natural polymer that has been widely used in the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw).
34299652	9	30	theme	low	1814:1816	arg1	CS					1821:1822	low Mw CS	1814:1822	low Mw CS	1814:1822	Overall, these results support the potential of low Mw CS for coating polymeric devices such as IMDs where the two bacteria tested are common colonizers and reduce their biofilm formation.
34299652	1	31	theme	microbial	191:199	arg1	adhesion					201:208	microbial adhesion	191:208	microbial adhesion	191:208	Implantable medical devices (IMDs) are susceptible to microbial adhesion and biofilm formation, which lead to several clinical complications, including the occurrence of implant-associated infections.
34299652	7	32	theme	cells	1385:1389	arg1	number					1319:1324	the number	1315:1324	the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively	1315:1432	Chitosan-based surfaces were able to inhibit the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively, being their activity dependent on chitosan Mw.
34299652	2	33	theme	Polylactic	338:347	arg1	PLA					355:357	PLA	355:357	PLA	355:357	Polylactic acid (PLA) and its composites are currently used for the construction of IMDs.
34299652	2	33	theme	Polylactic	338:347	arg1	acid					349:352	Polylactic acid	338:352	Polylactic acid (PLA)	338:358	Polylactic acid (PLA) and its composites are currently used for the construction of IMDs.
34299652	7	34	theme	viable	1336:1341	arg1	cells					1385:1389	total, viable, culturable, and viable but nonculturable cells	1329:1389	total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively	1329:1432	Chitosan-based surfaces were able to inhibit the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively, being their activity dependent on chitosan Mw.
34299652	0	35	theme	Surfaces	30:37	arg1	Development					0:10	Development	0:10	Development of Chitosan-Based Surfaces	0:37	Development of Chitosan-Based Surfaces to Prevent Single- and Dual-Species Biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	4	36	theme	surfaces	688:695	arg1	performance					664:674	the performance	660:674	the performance of CS-based surfaces of different Mw	660:711	The present study aims to evaluate the performance of CS-based surfaces of different Mw to inhibit bacterial biofilm formation.
34299652	8	37	theme	biofilm	1713:1719	arg1	decrease					1666:1673	a decrease	1664:1673	a decrease in the biovolume	1664:1690	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	8	37	theme	biofilm	1713:1719	arg1	thickness					1696:1704	thickness	1696:1704	thickness of the biofilm formed on CS-based surfaces	1696:1747	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	4	38	theme	Mw	710:711	arg1	surfaces					688:695	CS-based surfaces	679:695	CS-based surfaces of different Mw	679:711	The present study aims to evaluate the performance of CS-based surfaces of different Mw to inhibit bacterial biofilm formation.
34299652	9	39	theme	CS	1821:1822	arg1	potential					1801:1809	the potential	1797:1809	the potential of low Mw CS for coating polymeric devices such as IMDs where the two bacteria tested are common colonizers and reduce their biofilm formation	1797:1952	Overall, these results support the potential of low Mw CS for coating polymeric devices such as IMDs where the two bacteria tested are common colonizers and reduce their biofilm formation.
34299652	7	40	theme	dual-species	1281:1292	arg1	biofilms					1294:1301	single- and dual-species biofilms	1269:1301	single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively	1269:1432	Chitosan-based surfaces were able to inhibit the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively, being their activity dependent on chitosan Mw.
34299652	0	41	theme	Chitosan-Based	15:28	arg1	Surfaces					30:37	Chitosan-Based Surfaces	15:37	Chitosan-Based Surfaces	15:37	Development of Chitosan-Based Surfaces to Prevent Single- and Dual-Species Biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	5	42	theme	electron	1011:1018	arg1	microscopy					1020:1029	scanning electron microscopy	1002:1029	scanning electron microscopy (SEM)	1002:1035	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	5	42	theme	electron	1011:1018	arg1	SEM					1032:1034	SEM	1032:1034	SEM	1032:1034	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	4	43	theme	different	700:708	arg1	Mw					710:711	different Mw	700:711	different Mw	700:711	The present study aims to evaluate the performance of CS-based surfaces of different Mw to inhibit bacterial biofilm formation.
34299652	1	44	theme	biofilm	214:220	arg1	formation					222:230	biofilm formation	214:230	biofilm formation	214:230	Implantable medical devices (IMDs) are susceptible to microbial adhesion and biofilm formation, which lead to several clinical complications, including the occurrence of implant-associated infections.
34299652	1	45	theme	implant-associated	307:324	arg1	infections					326:335	implant-associated infections	307:335	implant-associated infections	307:335	Implantable medical devices (IMDs) are susceptible to microbial adhesion and biofilm formation, which lead to several clinical complications, including the occurrence of implant-associated infections.
34299652	7	46	theme	single-	1269:1275	arg1	biofilms					1294:1301	single- and dual-species biofilms	1269:1301	single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively	1269:1432	Chitosan-based surfaces were able to inhibit the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively, being their activity dependent on chitosan Mw.
34299652	2	47	theme	IMDs	422:425	arg1	construction					406:417	the construction	402:417	the construction of IMDs	402:425	Polylactic acid (PLA) and its composites are currently used for the construction of IMDs.
34299652	8	48	from	effect	1486:1491	arg1	inhibition					1521:1530	the inhibition	1517:1530	the inhibition of biofilm formation	1517:1551	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	1	49	theme	infections	326:335	arg1	occurrence					293:302	the occurrence	289:302	the occurrence of implant-associated infections	289:335	Implantable medical devices (IMDs) are susceptible to microbial adhesion and biofilm formation, which lead to several clinical complications, including the occurrence of implant-associated infections.
34299652	7	50	theme	viable	1360:1365	arg1	cells					1385:1389	total, viable, culturable, and viable but nonculturable cells	1329:1389	total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively	1329:1432	Chitosan-based surfaces were able to inhibit the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively, being their activity dependent on chitosan Mw.
34299652	3	51	theme	molecular	602:610	arg1	Mw					620:621	Mw	620:621	Mw	620:621	In addition, chitosan (CS) is a natural polymer that has been widely used in the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw).
34299652	3	51	theme	molecular	602:610	arg1	weight					612:617	molecular weight	602:617	molecular weight (Mw)	602:622	In addition, chitosan (CS) is a natural polymer that has been widely used in the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw).
34299652	5	52	theme	CS-based	771:778	arg1	surfaces					780:787	CS-based surfaces	771:787	CS-based surfaces	771:787	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	9	53	theme	polymeric	1836:1844	arg1	devices					1846:1852	polymeric devices	1836:1852	polymeric devices such as IMDs where the two bacteria tested are common colonizers and reduce their biofilm formation	1836:1952	Overall, these results support the potential of low Mw CS for coating polymeric devices such as IMDs where the two bacteria tested are common colonizers and reduce their biofilm formation.
34299652	9	53	theme	polymeric	1836:1844	arg1	IMDs					1862:1865	IMDs	1862:1865	IMDs where the two bacteria tested are common colonizers and reduce their biofilm formation	1862:1952	Overall, these results support the potential of low Mw CS for coating polymeric devices such as IMDs where the two bacteria tested are common colonizers and reduce their biofilm formation.
34299652	7	54	theme	Chitosan-based	1205:1218	arg1	surfaces					1220:1227	Chitosan-based surfaces	1205:1227	Chitosan-based surfaces	1205:1227	Chitosan-based surfaces were able to inhibit the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively, being their activity dependent on chitosan Mw.
34299652	3	55	theme	antibiofilm	552:562	arg1	properties					564:573	its antimicrobial and antibiofilm properties	530:573	properties	564:573	In addition, chitosan (CS) is a natural polymer that has been widely used in the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw).
34299652	6	56	theme	antimicrobial	1042:1054	arg1	activity					1056:1063	The antimicrobial activity	1038:1063	The antimicrobial activity of the functionalized surfaces	1038:1094	The antimicrobial activity of the functionalized surfaces was evaluated against single- and dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	6	57	theme	functionalized	1072:1085	arg1	surfaces					1087:1094	the functionalized surfaces	1068:1094	the functionalized surfaces	1068:1094	The antimicrobial activity of the functionalized surfaces was evaluated against single- and dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	8	58	theme	laser	1615:1619	arg1	microscopy					1630:1639	confocal laser scanning microscopy	1606:1639	confocal laser scanning microscopy (CLSM)	1606:1646	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	8	58	theme	laser	1615:1619	arg1	CLSM					1642:1645	CLSM	1642:1645	CLSM	1642:1645	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	7	59	theme	culturable	1344:1353	arg1	cells					1385:1389	total, viable, culturable, and viable but nonculturable cells	1329:1389	total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively	1329:1432	Chitosan-based surfaces were able to inhibit the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively, being their activity dependent on chitosan Mw.
34299652	1	60	theme	Implantable	137:147	arg1	IMDs					166:169	IMDs	166:169	IMDs	166:169	Implantable medical devices (IMDs) are susceptible to microbial adhesion and biofilm formation, which lead to several clinical complications, including the occurrence of implant-associated infections.
34299652	1	60	theme	Implantable	137:147	arg1	devices					157:163	Implantable medical devices	137:163	Implantable medical devices (IMDs)	137:170	Implantable medical devices (IMDs) are susceptible to microbial adhesion and biofilm formation, which lead to several clinical complications, including the occurrence of implant-associated infections.
34299652	7	61	theme	total	1329:1333	arg1	cells					1385:1389	total, viable, culturable, and viable but nonculturable cells	1329:1389	total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively	1329:1432	Chitosan-based surfaces were able to inhibit the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively, being their activity dependent on chitosan Mw.
34299652	5	62	theme	angle	931:935	arg1	Fourier					951:957	Fourier	951:957	Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM)	951:1035	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	5	62	theme	angle	931:935	arg1	measurements					937:948	contact angle measurements	923:948	contact angle measurements	923:948	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	5	63	dep	transform	959:967	arg1	infrared					969:976	infrared	969:976	transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM)	959:1035	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	1	64	theme	medical	149:155	arg1	IMDs					166:169	IMDs	166:169	IMDs	166:169	Implantable medical devices (IMDs) are susceptible to microbial adhesion and biofilm formation, which lead to several clinical complications, including the occurrence of implant-associated infections.
34299652	1	64	theme	medical	149:155	arg1	devices					157:163	Implantable medical devices	137:163	Implantable medical devices (IMDs)	137:170	Implantable medical devices (IMDs) are susceptible to microbial adhesion and biofilm formation, which lead to several clinical complications, including the occurrence of implant-associated infections.
34299652	5	65	theme	surface	885:891	arg1	homogeneity					893:903	surface homogeneity	885:903	surface homogeneity	885:903	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	8	66	theme	surfaces	1505:1512	arg1	effect					1486:1491	The effect	1482:1491	The effect of CS-based surfaces on the inhibition of biofilm formation	1482:1551	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	4	67	theme	bacterial	724:732	arg1	formation					742:750	bacterial biofilm formation	724:750	bacterial biofilm formation	724:750	The present study aims to evaluate the performance of CS-based surfaces of different Mw to inhibit bacterial biofilm formation.
34299652	4	68	theme	CS-based	679:686	arg1	surfaces					688:695	CS-based surfaces	679:695	CS-based surfaces of different Mw	679:711	The present study aims to evaluate the performance of CS-based surfaces of different Mw to inhibit bacterial biofilm formation.
34299652	2	69	used	used	393:396	arg2	acid					349:352	Polylactic acid	338:352	Polylactic acid (PLA)	338:358	Polylactic acid (PLA) and its composites are currently used for the construction of IMDs.
34299652	2	69	used	used	393:396	arg2	composites					368:377	its composites	364:377	its composites	364:377	Polylactic acid (PLA) and its composites are currently used for the construction of IMDs.
34299652	2	69	used	used	393:396	arg2	PLA					355:357	PLA	355:357	PLA	355:357	Polylactic acid (PLA) and its composites are currently used for the construction of IMDs.
34299652	7	70	dep	%	1399:1399	arg1	up					1391:1392	up	1391:1392	up	1391:1392	Chitosan-based surfaces were able to inhibit the development of single- and dual-species biofilms by reducing the number of total, viable, culturable, and viable but nonculturable cells up to 79%, 90%, 81%, and 96%, respectively, being their activity dependent on chitosan Mw.
34299652	8	71	theme	biofilm	1573:1579	arg1	analysis					1591:1598	biofilm structure analysis	1573:1598	biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA	1573:1763	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	3	72	theme	natural	460:466	arg1	chitosan					441:448	chitosan	441:448	chitosan (CS)	441:453	In addition, chitosan (CS) is a natural polymer that has been widely used in the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw).
34299652	3	72	theme	natural	460:466	arg1	polymer					468:474	a natural polymer	458:474	a natural polymer that has been widely used in the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw)	458:622	In addition, chitosan (CS) is a natural polymer that has been widely used in the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw).
34299652	5	73	theme	scanning	1002:1009	arg1	microscopy					1020:1029	scanning electron microscopy	1002:1029	scanning electron microscopy (SEM)	1002:1035	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	5	73	theme	scanning	1002:1009	arg1	SEM					1032:1034	SEM	1032:1034	SEM	1032:1034	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	6	74	theme	single-	1118:1124	arg1	biofilms					1143:1150	single- and dual-species biofilms	1118:1150	single- and dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa	1118:1202	The antimicrobial activity of the functionalized surfaces was evaluated against single- and dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	5	75	theme	CS	838:839	arg1	presence					826:833	the presence	822:833	the presence of CS and its derivatives onto PLA films, as well surface homogeneity	822:903	For this purpose, CS-based surfaces were produced by dip-coating and the presence of CS and its derivatives onto PLA films, as well surface homogeneity were confirmed by contact angle measurements, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
34299652	0	76	theme	Dual-Species	62:73	arg1	Biofilms					75:82	Dual-Species Biofilms	62:82	Dual-Species Biofilms	62:82	Development of Chitosan-Based Surfaces to Prevent Single- and Dual-Species Biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
34299652	3	77	used	used	497:500	arg2	polymer					468:474	a natural polymer	458:474	a natural polymer that has been widely used in the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw)	458:622	In addition, chitosan (CS) is a natural polymer that has been widely used in the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw).
34299652	3	77	used	used	497:500	arg2	chitosan					441:448	chitosan	441:448	chitosan (CS)	441:453	In addition, chitosan (CS) is a natural polymer that has been widely used in the medical field due to its antimicrobial and antibiofilm properties, which can be dependent on molecular weight (Mw).
34299652	8	78	theme	formation	1543:1551	arg1	inhibition					1521:1530	the inhibition	1517:1530	the inhibition of biofilm formation	1517:1551	The effect of CS-based surfaces on the inhibition of biofilm formation was corroborated by biofilm structure analysis using confocal laser scanning microscopy (CLSM), which revealed a decrease in the biovolume and thickness of the biofilm formed on CS-based surfaces compared to PLA.
34299652	1	79	theme	several	247:253	arg1	complications					264:276	several clinical complications	247:276	several clinical complications	247:276	Implantable medical devices (IMDs) are susceptible to microbial adhesion and biofilm formation, which lead to several clinical complications, including the occurrence of implant-associated infections.
34299652	1	79	theme	several	247:253	arg1	occurrence					293:302	the occurrence	289:302	the occurrence of implant-associated infections	289:335	Implantable medical devices (IMDs) are susceptible to microbial adhesion and biofilm formation, which lead to several clinical complications, including the occurrence of implant-associated infections.
33992651	5	0	theme	gut	818:820	arg1	composition					833:843	the gut microbiota composition	814:843	the gut microbiota composition	814:843	LBP + AE showed high abundance and diversity of gut microbiota, restored the gut microbiota composition, increased some Bacteroidetes, short chain fatty acids, but decreased Proteobacteria and the ratio of Firmicutes/Bacteroidetes.
33992651	0	1	theme	liver	93:97	arg1	disease					99:105	nonalcoholic fatty liver disease	74:105	nonalcoholic fatty liver disease	74:105	Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation.
33992651	7	2	theme	hepatic	1192:1198	arg1	proteins					1212:1219	hepatic LPS-binding proteins	1192:1219	hepatic LPS-binding proteins	1192:1219	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	2	3	theme	barbarum	365:372	arg1	polysaccharides					374:388	Lycium barbarum polysaccharides	358:388	Lycium barbarum polysaccharides (LBPs)	358:395	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	2	3	theme	barbarum	365:372	arg1	prebiotic					427:435	a potential prebiotic	415:435	a potential prebiotic	415:435	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	2	3	theme	barbarum	365:372	arg1	exercise					450:457	aerobic exercise	442:457	aerobic exercise (AE)	442:462	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	2	3	theme	barbarum	365:372	arg1	LBPs					391:394	LBPs	391:394	LBPs	391:394	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	4	4	dep	combination	632:642	arg1	AE					651:652	AE	651:652	AE	651:652	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	4	4	dep	combination	632:642	arg1	LBP					645:647	LBP	645:647	LBP	645:647	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	4	5	from	inflammation	718:729	arg1	NAFLD					734:738	NAFLD	734:738	NAFLD	734:738	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	3	6	theme	combined	519:526	arg1	effects					528:534	their combined effects	513:534	their combined effects on intestinal microecology	513:561	However, their combined effects on intestinal microecology remain unclear.
33992651	3	7	from	effects	528:534	arg1	microecology					550:561	intestinal microecology	539:561	intestinal microecology	539:561	However, their combined effects on intestinal microecology remain unclear.
33992651	5	8	theme	short	876:880	arg1	acids					894:898	short chain fatty acids	876:898	short chain fatty acids	876:898	LBP + AE showed high abundance and diversity of gut microbiota, restored the gut microbiota composition, increased some Bacteroidetes, short chain fatty acids, but decreased Proteobacteria and the ratio of Firmicutes/Bacteroidetes.
33992651	6	9	theme	occludens-1	1102:1112	arg1	expression					1081:1090	the expression	1077:1090	the expression of zonula occludens-1 and occludin	1077:1125	Simultaneously, LBP, AE, and LBP + AE could restore the colonic and ileum tight junctions by increasing the expression of zonula occludens-1 and occludin.
33992651	1	10	theme	gut-liver	292:300	arg1	talk					308:311	the gut-liver cross talk	288:311	the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD)	288:355	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	4	11	theme	gut	658:660	arg1	composition					673:683	gut microbiota composition	658:683	gut microbiota composition	658:683	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	7	12	theme	related	1248:1254	arg1	indicators					1256:1265	related indicators	1248:1265	related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver	1248:1319	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	6	13	theme	zonula	1095:1100	arg1	occludens-1					1102:1112	zonula occludens-1	1095:1112	zonula occludens-1	1095:1112	Simultaneously, LBP, AE, and LBP + AE could restore the colonic and ileum tight junctions by increasing the expression of zonula occludens-1 and occludin.
33992651	1	14	theme	Gut	197:199	arg1	permeability					227:238	intestinal permeability	216:238	intestinal permeability	216:238	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	1	14	theme	Gut	197:199	arg1	microbiota					201:210	Gut microbiota	197:210	Gut microbiota	197:210	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	1	14	theme	Gut	197:199	arg1	players					277:283	the key players	269:283	the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD)	269:355	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	0	15	theme	gut	125:127	arg1	barrier					152:158	intestinal barrier	141:158	intestinal barrier	141:158	Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation.
33992651	0	15	theme	gut	125:127	arg1	microbiota					129:138	gut microbiota	125:138	gut microbiota	125:138	Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation.
33992651	7	16	theme	LPS/TLR4/NF-κB	1274:1287	arg1	pathway					1299:1305	the LPS/TLR4/NF-κB signaling pathway	1270:1305	the LPS/TLR4/NF-κB signaling pathway for the liver	1270:1319	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	0	17	theme	barbarum	7:14	arg1	polysaccharide					16:29	Lycium barbarum polysaccharide	0:29	Lycium barbarum polysaccharide combined with aerobic exercise	0:60	Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation.
33992651	7	18	theme	gut-derived	1152:1162	arg1	LPSs					1185:1188	LPSs	1185:1188	LPSs	1185:1188	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	7	18	theme	gut-derived	1152:1162	arg1	lipopolysaccharides					1164:1182	gut-derived lipopolysaccharides	1152:1182	gut-derived lipopolysaccharides (LPSs)	1152:1189	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	4	19	from	barrier	697:703	arg1	NAFLD					734:738	NAFLD	734:738	NAFLD	734:738	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	4	20	theme	intestinal	686:695	arg1	barrier					697:703	intestinal barrier	686:703	intestinal barrier	686:703	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	0	21	theme	Lycium	0:5	arg1	polysaccharide					16:29	Lycium barbarum polysaccharide	0:29	Lycium barbarum polysaccharide combined with aerobic exercise	0:60	Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation.
33992651	1	22	theme	cross	302:306	arg1	talk					308:311	the gut-liver cross talk	288:311	the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD)	288:355	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	1	23	from	talk	308:311	arg1	NAFLD					350:354	NAFLD	350:354	NAFLD	350:354	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	1	23	from	talk	308:311	arg1	disease					341:347	nonalcoholic fatty liver disease	316:347	nonalcoholic fatty liver disease (NAFLD)	316:355	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	5	24	theme	chain	882:886	arg1	acids					894:898	short chain fatty acids	876:898	short chain fatty acids	876:898	LBP + AE showed high abundance and diversity of gut microbiota, restored the gut microbiota composition, increased some Bacteroidetes, short chain fatty acids, but decreased Proteobacteria and the ratio of Firmicutes/Bacteroidetes.
33992651	5	25	dep	acids	894:898	arg1	Bacteroidetes					861:873	some Bacteroidetes, short chain fatty acids	856:898	Bacteroidetes	861:873	LBP + AE showed high abundance and diversity of gut microbiota, restored the gut microbiota composition, increased some Bacteroidetes, short chain fatty acids, but decreased Proteobacteria and the ratio of Firmicutes/Bacteroidetes.
33992651	1	26	theme	intestinal	216:225	arg1	players					277:283	the key players	269:283	the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD)	269:355	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	1	26	theme	intestinal	216:225	arg1	permeability					227:238	intestinal permeability	216:238	intestinal permeability	216:238	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	1	26	theme	intestinal	216:225	arg1	microbiota					201:210	Gut microbiota	197:210	Gut microbiota	197:210	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	5	27	theme	high	757:760	arg1	abundance					762:770	high abundance	757:770	high abundance	757:770	LBP + AE showed high abundance and diversity of gut microbiota, restored the gut microbiota composition, increased some Bacteroidetes, short chain fatty acids, but decreased Proteobacteria and the ratio of Firmicutes/Bacteroidetes.
33992651	8	28	theme	prebiotic	1373:1381	arg1	agent					1383:1387	a prebiotic agent	1371:1387	a prebiotic agent	1371:1387	Our results implied that LBP could be considered a prebiotic agent, and LBP + AE might be a promising treatment for NAFLD because it could maintain gut microbiota balance, thereby restoring intestinal barrier and exerting hepatic benefits.
33992651	0	29	theme	intestinal	141:150	arg1	barrier					152:158	intestinal barrier	141:158	intestinal barrier	141:158	Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation.
33992651	0	29	theme	intestinal	141:150	arg1	microbiota					129:138	gut microbiota	125:138	gut microbiota	125:138	Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation.
33992651	8	30	dep	maintain	1461:1468	arg1	exerting					1535:1542	exerting	1535:1542	exerting hepatic benefits	1535:1559	Our results implied that LBP could be considered a prebiotic agent, and LBP + AE might be a promising treatment for NAFLD because it could maintain gut microbiota balance, thereby restoring intestinal barrier and exerting hepatic benefits.
33992651	8	30	dep	maintain	1461:1468	arg1	restoring					1502:1510	restoring	1502:1510	restoring intestinal barrier	1502:1529	Our results implied that LBP could be considered a prebiotic agent, and LBP + AE might be a promising treatment for NAFLD because it could maintain gut microbiota balance, thereby restoring intestinal barrier and exerting hepatic benefits.
33992651	5	31	theme	fatty	888:892	arg1	acids					894:898	short chain fatty acids	876:898	short chain fatty acids	876:898	LBP + AE showed high abundance and diversity of gut microbiota, restored the gut microbiota composition, increased some Bacteroidetes, short chain fatty acids, but decreased Proteobacteria and the ratio of Firmicutes/Bacteroidetes.
33992651	2	32	theme	potential	417:425	arg1	polysaccharides					374:388	Lycium barbarum polysaccharides	358:388	Lycium barbarum polysaccharides (LBPs)	358:395	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	2	32	theme	potential	417:425	arg1	prebiotic					427:435	a potential prebiotic	415:435	a potential prebiotic	415:435	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	2	32	theme	potential	417:425	arg1	exercise					450:457	aerobic exercise	442:457	aerobic exercise (AE)	442:462	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	7	33	link	gut-derived	1152:1162	arg1	LPSs					1185:1188	LPSs	1185:1188	LPSs	1185:1188	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	7	33	link	gut-derived	1152:1162	arg1	lipopolysaccharides					1164:1182	gut-derived lipopolysaccharides	1152:1182	gut-derived lipopolysaccharides (LPSs)	1152:1189	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	3	34	theme	intestinal	539:548	arg1	microecology					550:561	intestinal microecology	539:561	intestinal microecology	539:561	However, their combined effects on intestinal microecology remain unclear.
33992651	4	35	theme	LBP	615:617	arg1	effects					604:610	the effects	600:610	the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD	600:738	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	0	36	theme	aerobic	45:51	arg1	exercise					53:60	aerobic exercise	45:60	aerobic exercise	45:60	Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation.
33992651	1	37	theme	nonalcoholic	316:327	arg1	NAFLD					350:354	NAFLD	350:354	NAFLD	350:354	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	1	37	theme	nonalcoholic	316:327	arg1	disease					341:347	nonalcoholic fatty liver disease	316:347	nonalcoholic fatty liver disease (NAFLD)	316:355	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	1	38	from	players	277:283	arg1	talk					308:311	the gut-liver cross talk	288:311	the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD)	288:355	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	5	39	theme	Firmicutes/Bacteroidetes	947:970	arg1	ratio					938:942	the ratio	934:942	the ratio of Firmicutes/Bacteroidetes	934:970	LBP + AE showed high abundance and diversity of gut microbiota, restored the gut microbiota composition, increased some Bacteroidetes, short chain fatty acids, but decreased Proteobacteria and the ratio of Firmicutes/Bacteroidetes.
33992651	5	39	theme	Firmicutes/Bacteroidetes	947:970	arg1	Proteobacteria					915:928	Proteobacteria	915:928	Proteobacteria	915:928	LBP + AE showed high abundance and diversity of gut microbiota, restored the gut microbiota composition, increased some Bacteroidetes, short chain fatty acids, but decreased Proteobacteria and the ratio of Firmicutes/Bacteroidetes.
33992651	4	40	theme	combination	632:642	arg1	effects					604:610	the effects	600:610	the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD	600:738	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	5	41	theme	microbiota	793:802	arg1	diversity					776:784	diversity	776:784	diversity of gut microbiota	776:802	LBP + AE showed high abundance and diversity of gut microbiota, restored the gut microbiota composition, increased some Bacteroidetes, short chain fatty acids, but decreased Proteobacteria and the ratio of Firmicutes/Bacteroidetes.
33992651	5	41	theme	microbiota	793:802	arg1	abundance					762:770	high abundance	757:770	high abundance	757:770	LBP + AE showed high abundance and diversity of gut microbiota, restored the gut microbiota composition, increased some Bacteroidetes, short chain fatty acids, but decreased Proteobacteria and the ratio of Firmicutes/Bacteroidetes.
33992651	1	42	theme	fatty	329:333	arg1	NAFLD					350:354	NAFLD	350:354	NAFLD	350:354	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	1	42	theme	fatty	329:333	arg1	disease					341:347	nonalcoholic fatty liver disease	316:347	nonalcoholic fatty liver disease (NAFLD)	316:355	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	2	43	from	effects	486:492	arg1	NAFLD					497:501	NAFLD	497:501	NAFLD	497:501	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	4	44	theme	AE	620:621	arg1	effects					604:610	the effects	600:610	the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD	600:738	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	1	45	theme	liver	335:339	arg1	NAFLD					350:354	NAFLD	350:354	NAFLD	350:354	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	1	45	theme	liver	335:339	arg1	disease					341:347	nonalcoholic fatty liver disease	316:347	nonalcoholic fatty liver disease (NAFLD)	316:355	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	0	46	theme	hepatic	175:181	arg1	inflammation					183:194	hepatic inflammation	175:194	hepatic inflammation	175:194	Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation.
33992651	2	47	theme	protective	475:484	arg1	effects					486:492	protective effects	475:492	protective effects on NAFLD	475:501	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	6	48	dep	colonic	1029:1035	arg1	junctions					1053:1061	tight junctions	1047:1061	tight junctions	1047:1061	Simultaneously, LBP, AE, and LBP + AE could restore the colonic and ileum tight junctions by increasing the expression of zonula occludens-1 and occludin.
33992651	2	49	theme	Lycium	358:363	arg1	polysaccharides					374:388	Lycium barbarum polysaccharides	358:388	Lycium barbarum polysaccharides (LBPs)	358:395	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	2	49	theme	Lycium	358:363	arg1	prebiotic					427:435	a potential prebiotic	415:435	a potential prebiotic	415:435	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	2	49	theme	Lycium	358:363	arg1	exercise					450:457	aerobic exercise	442:457	aerobic exercise (AE)	442:462	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	2	49	theme	Lycium	358:363	arg1	LBPs					391:394	LBPs	391:394	LBPs	391:394	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	8	50	theme	intestinal	1512:1521	arg1	barrier					1523:1529	intestinal barrier	1512:1529	intestinal barrier	1512:1529	Our results implied that LBP could be considered a prebiotic agent, and LBP + AE might be a promising treatment for NAFLD because it could maintain gut microbiota balance, thereby restoring intestinal barrier and exerting hepatic benefits.
33992651	8	51	theme	microbiota	1474:1483	arg1	balance					1485:1491	gut microbiota balance	1470:1491	gut microbiota balance	1470:1491	Our results implied that LBP could be considered a prebiotic agent, and LBP + AE might be a promising treatment for NAFLD because it could maintain gut microbiota balance, thereby restoring intestinal barrier and exerting hepatic benefits.
33992651	6	52	theme	tight	1047:1051	arg1	junctions					1053:1061	tight junctions	1047:1061	tight junctions	1047:1061	Simultaneously, LBP, AE, and LBP + AE could restore the colonic and ileum tight junctions by increasing the expression of zonula occludens-1 and occludin.
33992651	4	53	from	composition	673:683	arg1	NAFLD					734:738	NAFLD	734:738	NAFLD	734:738	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	7	54	theme	pathway	1299:1305	arg1	proteins					1212:1219	hepatic LPS-binding proteins	1192:1219	hepatic LPS-binding proteins	1192:1219	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	7	54	theme	pathway	1299:1305	arg1	factors					1235:1241	inflammatory factors	1222:1241	inflammatory factors	1222:1241	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	7	54	theme	pathway	1299:1305	arg1	lipopolysaccharides					1164:1182	gut-derived lipopolysaccharides	1152:1182	gut-derived lipopolysaccharides (LPSs)	1152:1189	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	7	54	theme	pathway	1299:1305	arg1	LPSs					1185:1188	LPSs	1185:1188	LPSs	1185:1188	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	7	54	theme	pathway	1299:1305	arg1	indicators					1256:1265	related indicators	1248:1265	related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver	1248:1319	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	8	55	theme	gut	1470:1472	arg1	balance					1485:1491	gut microbiota balance	1470:1491	gut microbiota balance	1470:1491	Our results implied that LBP could be considered a prebiotic agent, and LBP + AE might be a promising treatment for NAFLD because it could maintain gut microbiota balance, thereby restoring intestinal barrier and exerting hepatic benefits.
33992651	4	56	from	effects	604:610	arg1	barrier					697:703	intestinal barrier	686:703	intestinal barrier	686:703	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	4	56	from	effects	604:610	arg1	inflammation					718:729	hepatic inflammation	710:729	hepatic inflammation	710:729	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	4	56	from	effects	604:610	arg1	composition					673:683	gut microbiota composition	658:683	gut microbiota composition	658:683	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	7	57	theme	LPS-binding	1200:1210	arg1	proteins					1212:1219	hepatic LPS-binding proteins	1192:1219	hepatic LPS-binding proteins	1192:1219	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	7	58	theme	inflammatory	1222:1233	arg1	factors					1235:1241	inflammatory factors	1222:1241	inflammatory factors	1222:1241	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	4	59	theme	hepatic	710:716	arg1	inflammation					718:729	hepatic inflammation	710:729	hepatic inflammation	710:729	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	4	60	theme	microbiota	662:671	arg1	composition					673:683	gut microbiota composition	658:683	gut microbiota composition	658:683	This study evaluated the effects of LBP, AE, and its combination (LBP + AE) on gut microbiota composition, intestinal barrier, and hepatic inflammation in NAFLD.
33992651	0	61	theme	fatty	87:91	arg1	disease					99:105	nonalcoholic fatty liver disease	74:105	nonalcoholic fatty liver disease	74:105	Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation.
33992651	5	62	theme	gut	789:791	arg1	microbiota					793:802	gut microbiota	789:802	gut microbiota	789:802	LBP + AE showed high abundance and diversity of gut microbiota, restored the gut microbiota composition, increased some Bacteroidetes, short chain fatty acids, but decreased Proteobacteria and the ratio of Firmicutes/Bacteroidetes.
33992651	7	63	theme	signaling	1289:1297	arg1	pathway					1299:1305	the LPS/TLR4/NF-κB signaling pathway	1270:1305	the LPS/TLR4/NF-κB signaling pathway for the liver	1270:1319	They also downregulated gut-derived lipopolysaccharides (LPSs), hepatic LPS-binding proteins, inflammatory factors, and related indicators of the LPS/TLR4/NF-κB signaling pathway for the liver.
33992651	5	64	theme	microbiota	822:831	arg1	composition					833:843	the gut microbiota composition	814:843	the gut microbiota composition	814:843	LBP + AE showed high abundance and diversity of gut microbiota, restored the gut microbiota composition, increased some Bacteroidetes, short chain fatty acids, but decreased Proteobacteria and the ratio of Firmicutes/Bacteroidetes.
33992651	8	65	theme	hepatic	1544:1550	arg1	benefits					1552:1559	hepatic benefits	1544:1559	hepatic benefits	1544:1559	Our results implied that LBP could be considered a prebiotic agent, and LBP + AE might be a promising treatment for NAFLD because it could maintain gut microbiota balance, thereby restoring intestinal barrier and exerting hepatic benefits.
33992651	0	66	theme	nonalcoholic	74:85	arg1	disease					99:105	nonalcoholic fatty liver disease	74:105	nonalcoholic fatty liver disease	74:105	Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation.
33992651	8	67	theme	promising	1414:1422	arg1	treatment					1424:1432	a promising treatment	1412:1432	a promising treatment for NAFLD	1412:1442	Our results implied that LBP could be considered a prebiotic agent, and LBP + AE might be a promising treatment for NAFLD because it could maintain gut microbiota balance, thereby restoring intestinal barrier and exerting hepatic benefits.
33992651	8	67	theme	promising	1414:1422	arg1	AE					1400:1401	AE	1400:1401	AE	1400:1401	Our results implied that LBP could be considered a prebiotic agent, and LBP + AE might be a promising treatment for NAFLD because it could maintain gut microbiota balance, thereby restoring intestinal barrier and exerting hepatic benefits.
33992651	8	67	theme	promising	1414:1422	arg1	LBP					1394:1396	LBP	1394:1396	LBP	1394:1396	Our results implied that LBP could be considered a prebiotic agent, and LBP + AE might be a promising treatment for NAFLD because it could maintain gut microbiota balance, thereby restoring intestinal barrier and exerting hepatic benefits.
33992651	6	68	theme	occludin	1118:1125	arg1	expression					1081:1090	the expression	1077:1090	the expression of zonula occludens-1 and occludin	1077:1125	Simultaneously, LBP, AE, and LBP + AE could restore the colonic and ileum tight junctions by increasing the expression of zonula occludens-1 and occludin.
33992651	2	69	theme	aerobic	442:448	arg1	polysaccharides					374:388	Lycium barbarum polysaccharides	358:388	Lycium barbarum polysaccharides (LBPs)	358:395	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	2	69	theme	aerobic	442:448	arg1	prebiotic					427:435	a potential prebiotic	415:435	a potential prebiotic	415:435	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	2	69	theme	aerobic	442:448	arg1	AE					460:461	AE	460:461	AE	460:461	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	2	69	theme	aerobic	442:448	arg1	exercise					450:457	aerobic exercise	442:457	aerobic exercise (AE)	442:462	Lycium barbarum polysaccharides (LBPs), which seem to be a potential prebiotic, and aerobic exercise (AE) have shown protective effects on NAFLD.
33992651	1	70	theme	key	273:275	arg1	permeability					227:238	intestinal permeability	216:238	intestinal permeability	216:238	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	1	70	theme	key	273:275	arg1	microbiota					201:210	Gut microbiota	197:210	Gut microbiota	197:210	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33992651	1	70	theme	key	273:275	arg1	players					277:283	the key players	269:283	the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD)	269:355	Gut microbiota and intestinal permeability have been demonstrated to be the key players in the gut-liver cross talk in nonalcoholic fatty liver disease (NAFLD).
33730647	1	0	theme	aquatic	116:122	arg1	systems					124:130	aquatic systems	116:130	aquatic systems	116:130	Excess phosphorous (P) in aquatic systems causes adverse environmental impacts including eutrophication.
33730647	7	1	from	species	1334:1340	arg1	adsorbents					1353:1362	all the adsorbents	1345:1362	all the adsorbents	1345:1362	Molecular level observations of the P K-edge XANES spectra confirmed that phosphate associated with iron (Fe) minerals (Fe-P) were the primary species in all the adsorbents.
33730647	2	2	from	mill	295:298	arg1	Fe					217:218	Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill	217:298	Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C	217:374	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	6	3	theme	pseudo-first-order	1000:1017	arg1	model					1027:1031	The pseudo-first-order kinetic model	996:1031	The pseudo-first-order kinetic model	996:1031	The pseudo-first-order kinetic model suitably explained the phosphate adsorption on BC-C and BC-N, while data of FBC-N and FBC-C followed the pseudo-second-order and Elovich model, respectively.
33730647	8	4	theme	bio-based	1536:1544	arg1	management					1546:1555	bio-based management	1536:1555	bio-based management of hazardous waste	1536:1574	This study suggests that FBCs hold high potential as inexpensive and green adsorbents for remediating phosphate in contaminated water, and encourage resource recovery via bio-based management of hazardous waste.
33730647	6	5	theme	kinetic	1019:1025	arg1	model					1027:1031	The pseudo-first-order kinetic model	996:1031	The pseudo-first-order kinetic model	996:1031	The pseudo-first-order kinetic model suitably explained the phosphate adsorption on BC-C and BC-N, while data of FBC-N and FBC-C followed the pseudo-second-order and Elovich model, respectively.
33730647	4	6	theme	other	741:745	arg1	adsorbents					747:756	three other adsorbents	735:756	three other adsorbents	735:756	The Freundlich isotherm model well described the phosphate adsorption on BC-N, while the Redlich-Peterson model best fitted the data of three other adsorbents.
33730647	1	7	from	systems	124:130	arg1	P					110:110	P	110:110	P	110:110	Excess phosphorous (P) in aquatic systems causes adverse environmental impacts including eutrophication.
33730647	1	7	from	systems	124:130	arg1	phosphorous					97:107	phosphorous	97:107	phosphorous	97:107	Excess phosphorous (P) in aquatic systems causes adverse environmental impacts including eutrophication.
33730647	7	8	theme	XANES	1236:1240	arg1	spectra					1242:1248	the P K-edge XANES spectra	1223:1248	the P K-edge XANES spectra	1223:1248	Molecular level observations of the P K-edge XANES spectra confirmed that phosphate associated with iron (Fe) minerals (Fe-P) were the primary species in all the adsorbents.
33730647	6	9	theme	Elovich	1162:1168	arg1	model					1170:1174	the pseudo-second-order and Elovich model	1134:1174	the pseudo-second-order and Elovich model	1134:1174	The pseudo-first-order kinetic model suitably explained the phosphate adsorption on BC-C and BC-N, while data of FBC-N and FBC-C followed the pseudo-second-order and Elovich model, respectively.
33730647	0	10	theme	phosphate	68:76	arg1	removal					57:63	the removal	53:63	the removal of phosphate from water	53:87	Fe(III) loaded chitosan-biochar composite fibers for the removal of phosphate from water.
33730647	6	11	theme	FBC-C	1119:1123	arg1	data					1101:1104	data	1101:1104	data of FBC-N and FBC-C	1101:1123	The pseudo-first-order kinetic model suitably explained the phosphate adsorption on BC-C and BC-N, while data of FBC-N and FBC-C followed the pseudo-second-order and Elovich model, respectively.
33730647	5	12	theme	better	895:900	arg1	adsorption					902:911	better adsorption	895:911	better adsorption by Fe(III) loaded chitosan-biochar composite fibers (FBCs) than pristine biochars	895:993	The maximum adsorption capacities were 9.63, 8.56, 16.43, and 19.24 mg P g-1 for BC-N, BC-C, FBC-N, and FBC-C, respectively, indicating better adsorption by Fe(III) loaded chitosan-biochar composite fibers (FBCs) than pristine biochars.
33730647	7	13	theme	level	1201:1205	arg1	observations					1207:1218	Molecular level observations	1191:1218	Molecular level observations of the P K-edge XANES spectra	1191:1248	Molecular level observations of the P K-edge XANES spectra confirmed that phosphate associated with iron (Fe) minerals (Fe-P) were the primary species in all the adsorbents.
33730647	8	14	theme	inexpensive	1418:1428	arg1	adsorbents					1440:1449	inexpensive and green adsorbents	1418:1449	inexpensive and green adsorbents	1418:1449	This study suggests that FBCs hold high potential as inexpensive and green adsorbents for remediating phosphate in contaminated water, and encourage resource recovery via bio-based management of hazardous waste.
33730647	5	15	theme	maximum	763:769	arg1	9.63					798:801	9.63	798:801	9.63	798:801	The maximum adsorption capacities were 9.63, 8.56, 16.43, and 19.24 mg P g-1 for BC-N, BC-C, FBC-N, and FBC-C, respectively, indicating better adsorption by Fe(III) loaded chitosan-biochar composite fibers (FBCs) than pristine biochars.
33730647	5	15	theme	maximum	763:769	arg1	capacities					782:791	The maximum adsorption capacities	759:791	The maximum adsorption capacities	759:791	The maximum adsorption capacities were 9.63, 8.56, 16.43, and 19.24 mg P g-1 for BC-N, BC-C, FBC-N, and FBC-C, respectively, indicating better adsorption by Fe(III) loaded chitosan-biochar composite fibers (FBCs) than pristine biochars.
33730647	3	16	theme	Raman	459:463	arg1	spectroscopy					465:476	Raman spectroscopy	459:476	Raman spectroscopy	459:476	Investigations using SEM/EDX, XPS, Raman spectroscopy, and specific surface area measurement revealed the morphological and physico-chemical characteristics of the adsorbent.
33730647	7	17	theme	spectra	1242:1248	arg1	observations					1207:1218	Molecular level observations	1191:1218	Molecular level observations of the P K-edge XANES spectra	1191:1248	Molecular level observations of the P K-edge XANES spectra confirmed that phosphate associated with iron (Fe) minerals (Fe-P) were the primary species in all the adsorbents.
33730647	2	18	theme	CO2	344:346	arg1	conditions					355:364	N2 (BC-N) and CO2 (BC-C) conditions	330:364	N2 (BC-N) and CO2 (BC-C) conditions	330:364	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	19	theme	composite	249:257	arg1	FBC-C					277:281	FBC-C	277:281	FBC-C	277:281	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	19	theme	composite	249:257	arg1	FBC-N					267:271	FBC-N	267:271	FBC-N	267:271	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	19	theme	composite	249:257	arg1	fibers					259:264	loaded chitosan-biochar composite fibers	225:264	Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C	217:374	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	1	20	theme	adverse	139:145	arg1	eutrophication					179:192	eutrophication	179:192	eutrophication	179:192	Excess phosphorous (P) in aquatic systems causes adverse environmental impacts including eutrophication.
33730647	1	20	theme	adverse	139:145	arg1	impacts					161:167	adverse environmental impacts	139:167	adverse environmental impacts including eutrophication	139:192	Excess phosphorous (P) in aquatic systems causes adverse environmental impacts including eutrophication.
33730647	2	21	theme	adsorptive	380:389	arg1	removal					391:397	adsorptive removal	380:397	adsorptive removal of phosphate from water	380:421	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	8	22	theme	green	1434:1438	arg1	adsorbents					1440:1449	inexpensive and green adsorbents	1418:1449	inexpensive and green adsorbents	1418:1449	This study suggests that FBCs hold high potential as inexpensive and green adsorbents for remediating phosphate in contaminated water, and encourage resource recovery via bio-based management of hazardous waste.
33730647	3	23	theme	area	500:503	arg1	measurement					505:515	specific surface area measurement	483:515	specific surface area measurement	483:515	Investigations using SEM/EDX, XPS, Raman spectroscopy, and specific surface area measurement revealed the morphological and physico-chemical characteristics of the adsorbent.
33730647	1	24	theme	environmental	147:159	arg1	eutrophication					179:192	eutrophication	179:192	eutrophication	179:192	Excess phosphorous (P) in aquatic systems causes adverse environmental impacts including eutrophication.
33730647	1	24	theme	environmental	147:159	arg1	impacts					161:167	adverse environmental impacts	139:167	adverse environmental impacts including eutrophication	139:192	Excess phosphorous (P) in aquatic systems causes adverse environmental impacts including eutrophication.
33730647	5	25	theme	adsorption	771:780	arg1	9.63					798:801	9.63	798:801	9.63	798:801	The maximum adsorption capacities were 9.63, 8.56, 16.43, and 19.24 mg P g-1 for BC-N, BC-C, FBC-N, and FBC-C, respectively, indicating better adsorption by Fe(III) loaded chitosan-biochar composite fibers (FBCs) than pristine biochars.
33730647	5	25	theme	adsorption	771:780	arg1	capacities					782:791	The maximum adsorption capacities	759:791	The maximum adsorption capacities	759:791	The maximum adsorption capacities were 9.63, 8.56, 16.43, and 19.24 mg P g-1 for BC-N, BC-C, FBC-N, and FBC-C, respectively, indicating better adsorption by Fe(III) loaded chitosan-biochar composite fibers (FBCs) than pristine biochars.
33730647	4	26	theme	Redlich-Peterson	688:703	arg1	model					705:709	the Redlich-Peterson model	684:709	the Redlich-Peterson model	684:709	The Freundlich isotherm model well described the phosphate adsorption on BC-N, while the Redlich-Peterson model best fitted the data of three other adsorbents.
33730647	1	27	from	phosphorous	97:107	arg1	systems					124:130	aquatic systems	116:130	aquatic systems	116:130	Excess phosphorous (P) in aquatic systems causes adverse environmental impacts including eutrophication.
33730647	3	28	theme	specific	483:490	arg1	measurement					505:515	specific surface area measurement	483:515	specific surface area measurement	483:515	Investigations using SEM/EDX, XPS, Raman spectroscopy, and specific surface area measurement revealed the morphological and physico-chemical characteristics of the adsorbent.
33730647	5	29	theme	loaded	924:929	arg1	fibers					958:963	loaded chitosan-biochar composite fibers	924:963	Fe(III) loaded chitosan-biochar composite fibers (FBCs)	916:970	The maximum adsorption capacities were 9.63, 8.56, 16.43, and 19.24 mg P g-1 for BC-N, BC-C, FBC-N, and FBC-C, respectively, indicating better adsorption by Fe(III) loaded chitosan-biochar composite fibers (FBCs) than pristine biochars.
33730647	7	30	theme	K-edge	1229:1234	arg1	spectra					1242:1248	the P K-edge XANES spectra	1223:1248	the P K-edge XANES spectra	1223:1248	Molecular level observations of the P K-edge XANES spectra confirmed that phosphate associated with iron (Fe) minerals (Fe-P) were the primary species in all the adsorbents.
33730647	5	31	dep	Fe	916:917	arg1	III					919:921	III	919:921	III	919:921	The maximum adsorption capacities were 9.63, 8.56, 16.43, and 19.24 mg P g-1 for BC-N, BC-C, FBC-N, and FBC-C, respectively, indicating better adsorption by Fe(III) loaded chitosan-biochar composite fibers (FBCs) than pristine biochars.
33730647	5	31	dep	Fe	916:917	arg1	fibers					958:963	loaded chitosan-biochar composite fibers	924:963	Fe(III) loaded chitosan-biochar composite fibers (FBCs)	916:970	The maximum adsorption capacities were 9.63, 8.56, 16.43, and 19.24 mg P g-1 for BC-N, BC-C, FBC-N, and FBC-C, respectively, indicating better adsorption by Fe(III) loaded chitosan-biochar composite fibers (FBCs) than pristine biochars.
33730647	7	32	theme	primary	1326:1332	arg1	species					1334:1340	the primary species	1322:1340	the primary species	1322:1340	Molecular level observations of the P K-edge XANES spectra confirmed that phosphate associated with iron (Fe) minerals (Fe-P) were the primary species in all the adsorbents.
33730647	7	32	theme	primary	1326:1332	arg1	phosphate					1265:1273	phosphate	1265:1273	phosphate associated with iron (Fe) minerals (Fe-P)	1265:1315	Molecular level observations of the P K-edge XANES spectra confirmed that phosphate associated with iron (Fe) minerals (Fe-P) were the primary species in all the adsorbents.
33730647	5	33	theme	pristine	977:984	arg1	biochars					986:993	pristine biochars	977:993	pristine biochars	977:993	The maximum adsorption capacities were 9.63, 8.56, 16.43, and 19.24 mg P g-1 for BC-N, BC-C, FBC-N, and FBC-C, respectively, indicating better adsorption by Fe(III) loaded chitosan-biochar composite fibers (FBCs) than pristine biochars.
33730647	3	34	theme	surface	492:498	arg1	measurement					505:515	specific surface area measurement	483:515	specific surface area measurement	483:515	Investigations using SEM/EDX, XPS, Raman spectroscopy, and specific surface area measurement revealed the morphological and physico-chemical characteristics of the adsorbent.
33730647	4	35	theme	phosphate	648:656	arg1	adsorption					658:667	the phosphate adsorption	644:667	the phosphate adsorption	644:667	The Freundlich isotherm model well described the phosphate adsorption on BC-N, while the Redlich-Peterson model best fitted the data of three other adsorbents.
33730647	0	36	theme	chitosan-biochar	15:30	arg1	fibers					42:47	chitosan-biochar composite fibers	15:47	chitosan-biochar composite fibers	15:47	Fe(III) loaded chitosan-biochar composite fibers for the removal of phosphate from water.
33730647	6	37	theme	phosphate	1056:1064	arg1	adsorption					1066:1075	the phosphate adsorption	1052:1075	the phosphate adsorption on BC-C and BC-N	1052:1092	The pseudo-first-order kinetic model suitably explained the phosphate adsorption on BC-C and BC-N, while data of FBC-N and FBC-C followed the pseudo-second-order and Elovich model, respectively.
33730647	6	38	theme	pseudo-second-order	1138:1156	arg1	model					1170:1174	the pseudo-second-order and Elovich model	1134:1174	the pseudo-second-order and Elovich model	1134:1174	The pseudo-first-order kinetic model suitably explained the phosphate adsorption on BC-C and BC-N, while data of FBC-N and FBC-C followed the pseudo-second-order and Elovich model, respectively.
33730647	2	39	from	water	417:421	arg1	removal					391:397	adsorptive removal	380:397	adsorptive removal of phosphate from water	380:421	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	3	40	theme	morphological	530:542	arg1	characteristics					565:579	the morphological and physico-chemical characteristics	526:579	the morphological and physico-chemical characteristics of the adsorbent	526:596	Investigations using SEM/EDX, XPS, Raman spectroscopy, and specific surface area measurement revealed the morphological and physico-chemical characteristics of the adsorbent.
33730647	4	41	theme	Freundlich	603:612	arg1	model					623:627	The Freundlich isotherm model	599:627	The Freundlich isotherm model	599:627	The Freundlich isotherm model well described the phosphate adsorption on BC-N, while the Redlich-Peterson model best fitted the data of three other adsorbents.
33730647	2	42	theme	phosphate	402:410	arg1	removal					391:397	adsorptive removal	380:397	adsorptive removal of phosphate from water	380:421	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	3	43	theme	adsorbent	588:596	arg1	characteristics					565:579	the morphological and physico-chemical characteristics	526:579	the morphological and physico-chemical characteristics of the adsorbent	526:596	Investigations using SEM/EDX, XPS, Raman spectroscopy, and specific surface area measurement revealed the morphological and physico-chemical characteristics of the adsorbent.
33730647	2	44	theme	Fe	217:218	arg1	biochar					307:313	Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar	217:313	Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C	217:374	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	45	dep	Fe	217:218	arg1	FBC-C					277:281	FBC-C	277:281	FBC-C	277:281	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	45	dep	Fe	217:218	arg1	FBC-N					267:271	FBC-N	267:271	FBC-N	267:271	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	45	dep	Fe	217:218	arg1	fibers					259:264	loaded chitosan-biochar composite fibers	225:264	Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C	217:374	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	45	dep	Fe	217:218	arg1	III					220:222	III	220:222	III	220:222	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	8	46	theme	contaminated	1480:1491	arg1	water					1493:1497	contaminated water	1480:1497	contaminated water	1480:1497	This study suggests that FBCs hold high potential as inexpensive and green adsorbents for remediating phosphate in contaminated water, and encourage resource recovery via bio-based management of hazardous waste.
33730647	5	47	theme	composite	948:956	arg1	fibers					958:963	loaded chitosan-biochar composite fibers	924:963	Fe(III) loaded chitosan-biochar composite fibers (FBCs)	916:970	The maximum adsorption capacities were 9.63, 8.56, 16.43, and 19.24 mg P g-1 for BC-N, BC-C, FBC-N, and FBC-C, respectively, indicating better adsorption by Fe(III) loaded chitosan-biochar composite fibers (FBCs) than pristine biochars.
33730647	0	48	theme	composite	32:40	arg1	fibers					42:47	chitosan-biochar composite fibers	15:47	chitosan-biochar composite fibers	15:47	Fe(III) loaded chitosan-biochar composite fibers for the removal of phosphate from water.
33730647	8	49	theme	high	1400:1403	arg1	potential					1405:1413	high potential	1400:1413	high potential as inexpensive and green adsorbents for remediating phosphate in contaminated water	1400:1497	This study suggests that FBCs hold high potential as inexpensive and green adsorbents for remediating phosphate in contaminated water, and encourage resource recovery via bio-based management of hazardous waste.
33730647	6	50	from	adsorption	1066:1075	arg1	BC-N					1089:1092	BC-N	1089:1092	BC-N	1089:1092	The pseudo-first-order kinetic model suitably explained the phosphate adsorption on BC-C and BC-N, while data of FBC-N and FBC-C followed the pseudo-second-order and Elovich model, respectively.
33730647	6	50	from	adsorption	1066:1075	arg1	BC-C					1080:1083	BC-C	1080:1083	BC-C	1080:1083	The pseudo-first-order kinetic model suitably explained the phosphate adsorption on BC-C and BC-N, while data of FBC-N and FBC-C followed the pseudo-second-order and Elovich model, respectively.
33730647	2	51	theme	sludge	300:305	arg1	biochar					307:313	Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar	217:313	Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C	217:374	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	0	52	from	water	83:87	arg1	removal					57:63	the removal	53:63	the removal of phosphate from water	53:87	Fe(III) loaded chitosan-biochar composite fibers for the removal of phosphate from water.
33730647	2	53	theme	chitosan-biochar	232:247	arg1	FBC-C					277:281	FBC-C	277:281	FBC-C	277:281	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	53	theme	chitosan-biochar	232:247	arg1	FBC-N					267:271	FBC-N	267:271	FBC-N	267:271	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	53	theme	chitosan-biochar	232:247	arg1	fibers					259:264	loaded chitosan-biochar composite fibers	225:264	Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C	217:374	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	5	54	theme	chitosan-biochar	931:946	arg1	fibers					958:963	loaded chitosan-biochar composite fibers	924:963	Fe(III) loaded chitosan-biochar composite fibers (FBCs)	916:970	The maximum adsorption capacities were 9.63, 8.56, 16.43, and 19.24 mg P g-1 for BC-N, BC-C, FBC-N, and FBC-C, respectively, indicating better adsorption by Fe(III) loaded chitosan-biochar composite fibers (FBCs) than pristine biochars.
33730647	7	55	theme	Molecular	1191:1199	arg1	observations					1207:1218	Molecular level observations	1191:1218	Molecular level observations of the P K-edge XANES spectra	1191:1248	Molecular level observations of the P K-edge XANES spectra confirmed that phosphate associated with iron (Fe) minerals (Fe-P) were the primary species in all the adsorbents.
33730647	8	56	theme	waste	1570:1574	arg1	management					1546:1555	bio-based management	1536:1555	bio-based management of hazardous waste	1536:1574	This study suggests that FBCs hold high potential as inexpensive and green adsorbents for remediating phosphate in contaminated water, and encourage resource recovery via bio-based management of hazardous waste.
33730647	8	57	theme	resource	1514:1521	arg1	recovery					1523:1530	resource recovery	1514:1530	resource recovery	1514:1530	This study suggests that FBCs hold high potential as inexpensive and green adsorbents for remediating phosphate in contaminated water, and encourage resource recovery via bio-based management of hazardous waste.
33730647	2	58	theme	loaded	225:230	arg1	FBC-C					277:281	FBC-C	277:281	FBC-C	277:281	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	58	theme	loaded	225:230	arg1	FBC-N					267:271	FBC-N	267:271	FBC-N	267:271	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	58	theme	loaded	225:230	arg1	fibers					259:264	loaded chitosan-biochar composite fibers	225:264	Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C	217:374	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	59	theme	paper	289:293	arg1	mill					295:298	paper mill	289:298	paper mill	289:298	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	4	60	theme	adsorbents	747:756	arg1	data					727:730	the data	723:730	the data of three other adsorbents	723:756	The Freundlich isotherm model well described the phosphate adsorption on BC-N, while the Redlich-Peterson model best fitted the data of three other adsorbents.
33730647	7	61	theme	P	1227:1227	arg1	spectra					1242:1248	the P K-edge XANES spectra	1223:1248	the P K-edge XANES spectra	1223:1248	Molecular level observations of the P K-edge XANES spectra confirmed that phosphate associated with iron (Fe) minerals (Fe-P) were the primary species in all the adsorbents.
33730647	3	62	theme	physico-chemical	548:563	arg1	characteristics					565:579	the morphological and physico-chemical characteristics	526:579	the morphological and physico-chemical characteristics of the adsorbent	526:596	Investigations using SEM/EDX, XPS, Raman spectroscopy, and specific surface area measurement revealed the morphological and physico-chemical characteristics of the adsorbent.
33730647	2	63	dep	fibers	259:264	arg1	FBC-C					277:281	FBC-C	277:281	FBC-C	277:281	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	63	dep	fibers	259:264	arg1	FBC-N					267:271	FBC-N	267:271	FBC-N	267:271	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	2	63	dep	fibers	259:264	arg1	fibers					259:264	loaded chitosan-biochar composite fibers	225:264	Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C	217:374	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33730647	4	64	theme	isotherm	614:621	arg1	model					623:627	The Freundlich isotherm model	599:627	The Freundlich isotherm model	599:627	The Freundlich isotherm model well described the phosphate adsorption on BC-N, while the Redlich-Peterson model best fitted the data of three other adsorbents.
33730647	8	65	theme	hazardous	1560:1568	arg1	waste					1570:1574	hazardous waste	1560:1574	hazardous waste	1560:1574	This study suggests that FBCs hold high potential as inexpensive and green adsorbents for remediating phosphate in contaminated water, and encourage resource recovery via bio-based management of hazardous waste.
33730647	7	66	theme	iron	1291:1294	arg1	Fe-P					1311:1314	Fe-P	1311:1314	Fe-P	1311:1314	Molecular level observations of the P K-edge XANES spectra confirmed that phosphate associated with iron (Fe) minerals (Fe-P) were the primary species in all the adsorbents.
33730647	7	66	theme	iron	1291:1294	arg1	minerals					1301:1308	iron (Fe) minerals	1291:1308	iron (Fe) minerals (Fe-P)	1291:1315	Molecular level observations of the P K-edge XANES spectra confirmed that phosphate associated with iron (Fe) minerals (Fe-P) were the primary species in all the adsorbents.
33730647	6	67	theme	FBC-N	1109:1113	arg1	data					1101:1104	data	1101:1104	data of FBC-N and FBC-C	1101:1123	The pseudo-first-order kinetic model suitably explained the phosphate adsorption on BC-C and BC-N, while data of FBC-N and FBC-C followed the pseudo-second-order and Elovich model, respectively.
33730647	2	68	theme	N2	330:331	arg1	conditions					355:364	N2 (BC-N) and CO2 (BC-C) conditions	330:364	N2 (BC-N) and CO2 (BC-C) conditions	330:364	This study fabricated Fe(III) loaded chitosan-biochar composite fibers (FBC-N and FBC-C) from paper mill sludge biochar produced under N2 (BC-N) and CO2 (BC-C) conditions at 600 °C for adsorptive removal of phosphate from water.
33925764	5	0	theme	phase	815:819	arg1	PIT					844:846	PIT	844:846	PIT	844:846	Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT).
33925764	5	0	theme	phase	815:819	arg1	temperature					831:841	phase inversion temperature	815:841	phase inversion temperature (PIT)	815:847	Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT).
33925764	4	1	theme	nanoemulsions	531:543	arg1	fabrication					516:526	fabrication	516:526	fabrication of nanoemulsions containing lidocaine to provide an extended local anesthetic effect	516:611	However, fabrication of nanoemulsions containing lidocaine to provide an extended local anesthetic effect is challenging.
33925764	6	2	theme	oil	909:911	arg1	type					913:916	oil type	909:916	oil type	909:916	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	5	3	theme	o/w	712:714	arg1	nanocarriers					716:727	alginate-based o/w nanocarriers	697:727	alginate-based o/w nanocarriers	697:727	Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT).
33925764	6	4	theme	lidocaine	1014:1022	arg1	nanoemulsions					1024:1036	lidocaine nanoemulsions	1014:1036	lidocaine nanoemulsions	1014:1036	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	0	5	theme	Lidocaine	81:89	arg1	Delivery					69:76	Transdermal Drug Delivery	52:76	Transdermal Drug Delivery of Lidocaine	52:89	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.
33925764	6	6	dep	size	968:971	arg1	the					955:957	the	955:957	the	955:957	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	4	7	contain	containing	545:554	arg2	lidocaine					556:564	lidocaine	556:564	lidocaine	556:564	However, fabrication of nanoemulsions containing lidocaine to provide an extended local anesthetic effect is challenging.
33925764	4	7	contain	containing	545:554	arg1	nanoemulsions					531:543	nanoemulsions	531:543	nanoemulsions containing lidocaine	531:564	However, fabrication of nanoemulsions containing lidocaine to provide an extended local anesthetic effect is challenging.
33925764	8	8	theme	light	1260:1264	arg1	scattering					1266:1275	dynamic light scattering	1252:1275	dynamic light scattering (DLS)	1252:1281	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	8	8	theme	light	1260:1264	arg1	DLS					1278:1280	DLS	1278:1280	DLS	1278:1280	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	3	9	theme	lipophilic	386:395	arg1	molecules					397:405	lipophilic molecules	386:405	lipophilic molecules	386:405	Oil-in-water nanoemulsions are particularly suitable for encapsulation of lipophilic molecules because of their ability to form stable and transparent delivery systems with good skin permeation.
33925764	10	10	from	delivery	1514:1521	arg1	favorable					1484:1492	favorable	1484:1492	favorable	1484:1492	This extended-release profile is highly favorable in transdermal drug delivery and shows the great potential of this nanoemulsion as delivery system.
33925764	3	11	theme	molecules	397:405	arg1	encapsulation					369:381	encapsulation	369:381	encapsulation of lipophilic molecules	369:405	Oil-in-water nanoemulsions are particularly suitable for encapsulation of lipophilic molecules because of their ability to form stable and transparent delivery systems with good skin permeation.
33925764	5	12	theme	alginate-based	697:710	arg1	nanocarriers					716:727	alginate-based o/w nanocarriers	697:727	alginate-based o/w nanocarriers	697:727	Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT).
33925764	6	13	theme	skin	995:998	arg1	permeation					1000:1009	skin permeation	995:1009	skin permeation	995:1009	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	0	14	theme	Oil	109:111	arg1	Phase					113:117	the Oil Phase	105:117	the Oil Phase	105:117	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.
33925764	7	15	theme	dilution	1134:1141	arg1	function					1116:1123	a function	1114:1123	a function of water dilution	1114:1141	Structural characterization of lidocaine nanoemulsions as a function of water dilution was done using DSC.
33925764	5	16	theme	study	652:656	arg1	aim					640:642	the aim	636:642	the aim of this study	636:656	Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT).
33925764	2	17	theme	transdermal	276:286	arg1	transport					288:296	the transdermal transport	272:296	the transdermal transport of lidocaine	272:309	Microemulsions have shown great effectiveness for the transdermal transport of lidocaine.
33925764	1	18	theme	lidocaine	164:172	arg1	delivery					152:159	Transdermal drug delivery	135:159	Transdermal drug delivery of lidocaine	135:172	Transdermal drug delivery of lidocaine is a good choice for local anesthetic delivery.
33925764	1	18	theme	lidocaine	164:172	arg1	choice					184:189	a good choice	177:189	a good choice for local anesthetic delivery	177:219	Transdermal drug delivery of lidocaine is a good choice for local anesthetic delivery.
33925764	6	19	from	influence	869:877	arg1	size					968:971	particle size	959:971	particle size	959:971	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	6	19	from	influence	869:877	arg1	release					983:989	in vitro release	974:989	in vitro release	974:989	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	6	19	from	influence	869:877	arg1	permeation					1000:1009	skin permeation	995:1009	skin permeation	995:1009	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	5	20	theme	temperature	831:841	arg1	approaches					786:795	combined approaches	777:795	combined approaches of ultrasound and phase inversion temperature (PIT)	777:847	Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT).
33925764	6	21	theme	particle	959:966	arg1	size					968:971	particle size	959:971	particle size	959:971	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	5	22	theme	inversion	821:829	arg1	PIT					844:846	PIT	844:846	PIT	844:846	Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT).
33925764	5	22	theme	inversion	821:829	arg1	temperature					831:841	phase inversion temperature	815:841	phase inversion temperature (PIT)	815:847	Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT).
33925764	10	23	theme	great	1537:1541	arg1	potential					1543:1551	the great potential	1533:1551	the great potential of this nanoemulsion as delivery system	1533:1591	This extended-release profile is highly favorable in transdermal drug delivery and shows the great potential of this nanoemulsion as delivery system.
33925764	10	24	theme	delivery	1577:1584	arg1	system					1586:1591	delivery system	1577:1591	delivery system	1577:1591	This extended-release profile is highly favorable in transdermal drug delivery and shows the great potential of this nanoemulsion as delivery system.
33925764	3	25	theme	transparent	451:461	arg1	systems					472:478	stable and transparent delivery systems	440:478	stable and transparent delivery systems	440:478	Oil-in-water nanoemulsions are particularly suitable for encapsulation of lipophilic molecules because of their ability to form stable and transparent delivery systems with good skin permeation.
33925764	8	26	theme	d	1207:1207	arg1	nm					1215:1216	d < 150 nm	1207:1216	d < 150 nm	1207:1216	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	8	26	theme	d	1207:1207	arg1	diameters					1196:1204	small droplet diameters	1182:1204	small droplet diameters (d < 150 nm)	1182:1217	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	7	27	theme	water	1128:1132	arg1	dilution					1134:1141	water dilution	1128:1141	water dilution	1128:1141	Structural characterization of lidocaine nanoemulsions as a function of water dilution was done using DSC.
33925764	10	28	theme	extended-release	1449:1464	arg1	profile					1466:1472	This extended-release profile	1444:1472	This extended-release profile	1444:1472	This extended-release profile is highly favorable in transdermal drug delivery and shows the great potential of this nanoemulsion as delivery system.
33925764	8	29	theme	droplet	1188:1194	arg1	nm					1215:1216	d < 150 nm	1207:1216	d < 150 nm	1207:1216	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	8	29	theme	droplet	1188:1194	arg1	diameters					1196:1204	small droplet diameters	1182:1204	small droplet diameters (d < 150 nm)	1182:1217	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	3	30	theme	delivery	463:470	arg1	systems					472:478	stable and transparent delivery systems	440:478	stable and transparent delivery systems	440:478	Oil-in-water nanoemulsions are particularly suitable for encapsulation of lipophilic molecules because of their ability to form stable and transparent delivery systems with good skin permeation.
33925764	0	31	theme	O/W	30:32	arg1	Nanoemulsions					34:46	Alginate-Based O/W Nanoemulsions	15:46	Alginate-Based O/W Nanoemulsions	15:46	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.
33925764	4	32	theme	anesthetic	595:604	arg1	effect					606:611	an extended local anesthetic effect	577:611	an extended local anesthetic effect	577:611	However, fabrication of nanoemulsions containing lidocaine to provide an extended local anesthetic effect is challenging.
33925764	8	33	with	Nanoemulsions	1163:1175	arg1	nm					1215:1216	d < 150 nm	1207:1216	d < 150 nm	1207:1216	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	8	33	with	Nanoemulsions	1163:1175	arg1	diameters					1196:1204	small droplet diameters	1182:1204	small droplet diameters (d < 150 nm)	1182:1217	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	0	34	theme	Alginate-Based	15:28	arg1	Nanoemulsions					34:46	Alginate-Based O/W Nanoemulsions	15:46	Alginate-Based O/W Nanoemulsions	15:46	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.
33925764	0	35	theme	Phase	113:117	arg1	Influence					92:100	Influence	92:100	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.	0:133	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.
33925764	2	36	theme	lidocaine	301:309	arg1	transport					288:296	the transdermal transport	272:296	the transdermal transport of lidocaine	272:309	Microemulsions have shown great effectiveness for the transdermal transport of lidocaine.
33925764	8	37	theme	small	1182:1186	arg1	nm					1215:1216	d < 150 nm	1207:1216	d < 150 nm	1207:1216	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	8	37	theme	small	1182:1186	arg1	diameters					1196:1204	small droplet diameters	1182:1204	small droplet diameters (d < 150 nm)	1182:1217	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	3	38	theme	stable	440:445	arg1	systems					472:478	stable and transparent delivery systems	440:478	stable and transparent delivery systems	440:478	Oil-in-water nanoemulsions are particularly suitable for encapsulation of lipophilic molecules because of their ability to form stable and transparent delivery systems with good skin permeation.
33925764	6	39	theme	in	974:975	arg1	release					983:989	in vitro release	974:989	in vitro release	974:989	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	7	40	theme	nanoemulsions	1097:1109	arg1	characterization					1067:1082	Structural characterization	1056:1082	Structural characterization of lidocaine nanoemulsions as a function of water dilution	1056:1141	Structural characterization of lidocaine nanoemulsions as a function of water dilution was done using DSC.
33925764	3	41	theme	good	485:488	arg1	permeation					495:504	good skin permeation	485:504	good skin permeation	485:504	Oil-in-water nanoemulsions are particularly suitable for encapsulation of lipophilic molecules because of their ability to form stable and transparent delivery systems with good skin permeation.
33925764	1	42	theme	good	179:182	arg1	delivery					152:159	Transdermal drug delivery	135:159	Transdermal drug delivery of lidocaine	135:172	Transdermal drug delivery of lidocaine is a good choice for local anesthetic delivery.
33925764	1	42	theme	good	179:182	arg1	choice					184:189	a good choice	177:189	a good choice for local anesthetic delivery	177:219	Transdermal drug delivery of lidocaine is a good choice for local anesthetic delivery.
33925764	1	43	theme	local	195:199	arg1	delivery					212:219	local anesthetic delivery	195:219	local anesthetic delivery	195:219	Transdermal drug delivery of lidocaine is a good choice for local anesthetic delivery.
33925764	0	44	theme	Nanoemulsions	34:46	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.	0:133	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.
33925764	9	45	theme	content	1356:1362	arg1	%					1345:1345	90%	1343:1345	90% of their content within 24-h	1343:1374	These nanoemulsions were also able to release 90% of their content within 24-h through PDMS and pig skin and able to the drug release over a 48-h.
33925764	9	45	theme	content	1356:1362	arg1	content					1356:1362	their content	1350:1362	their content within 24-h	1350:1374	These nanoemulsions were also able to release 90% of their content within 24-h through PDMS and pig skin and able to the drug release over a 48-h.
33925764	0	46	theme	Surfactant	123:132	arg1	Influence					92:100	Influence	92:100	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.	0:133	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.
33925764	6	47	theme	composition	889:899	arg1	influence					869:877	the influence	865:877	the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions	865:1036	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	6	48	theme	nanoemulsions	1024:1036	arg1	size					968:971	particle size	959:971	particle size	959:971	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	6	48	theme	nanoemulsions	1024:1036	arg1	release					983:989	in vitro release	974:989	in vitro release	974:989	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	6	48	theme	nanoemulsions	1024:1036	arg1	permeation					1000:1009	skin permeation	995:1009	skin permeation	995:1009	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	3	49	theme	skin	490:493	arg1	permeation					495:504	good skin permeation	485:504	good skin permeation	485:504	Oil-in-water nanoemulsions are particularly suitable for encapsulation of lipophilic molecules because of their ability to form stable and transparent delivery systems with good skin permeation.
33925764	0	50	theme	Drug	64:67	arg1	Delivery					69:76	Transdermal Drug Delivery	52:76	Transdermal Drug Delivery of Lidocaine	52:89	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.
33925764	10	51	theme	nanoemulsion	1561:1572	arg1	potential					1543:1551	the great potential	1533:1551	the great potential of this nanoemulsion as delivery system	1533:1591	This extended-release profile is highly favorable in transdermal drug delivery and shows the great potential of this nanoemulsion as delivery system.
33925764	3	52	theme	Oil-in-water	312:323	arg1	nanoemulsions					325:337	Oil-in-water nanoemulsions	312:337	Oil-in-water nanoemulsions	312:337	Oil-in-water nanoemulsions are particularly suitable for encapsulation of lipophilic molecules because of their ability to form stable and transparent delivery systems with good skin permeation.
33925764	6	53	theme	system	882:887	arg1	composition					889:899	system composition	882:899	system composition	882:899	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	9	54	theme	drug	1418:1421	arg1	release					1423:1429	the drug release	1414:1429	the drug release	1414:1429	These nanoemulsions were also able to release 90% of their content within 24-h through PDMS and pig skin and able to the drug release over a 48-h.
33925764	10	55	theme	drug	1509:1512	arg1	delivery					1514:1521	transdermal drug delivery	1497:1521	transdermal drug delivery	1497:1521	This extended-release profile is highly favorable in transdermal drug delivery and shows the great potential of this nanoemulsion as delivery system.
33925764	0	56	theme	Transdermal	52:62	arg1	Delivery					69:76	Transdermal Drug Delivery	52:76	Transdermal Drug Delivery of Lidocaine	52:89	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.
33925764	4	57	theme	local	589:593	arg1	effect					606:611	an extended local anesthetic effect	577:611	an extended local anesthetic effect	577:611	However, fabrication of nanoemulsions containing lidocaine to provide an extended local anesthetic effect is challenging.
33925764	7	58	theme	lidocaine	1087:1095	arg1	nanoemulsions					1097:1109	lidocaine nanoemulsions	1087:1109	lidocaine nanoemulsions as a function of water dilution	1087:1141	Structural characterization of lidocaine nanoemulsions as a function of water dilution was done using DSC.
33925764	9	59	dep	PDMS	1384:1387	arg1	skin					1397:1400	skin	1397:1400	skin	1397:1400	These nanoemulsions were also able to release 90% of their content within 24-h through PDMS and pig skin and able to the drug release over a 48-h.
33925764	4	60	theme	extended	580:587	arg1	effect					606:611	an extended local anesthetic effect	577:611	an extended local anesthetic effect	577:611	However, fabrication of nanoemulsions containing lidocaine to provide an extended local anesthetic effect is challenging.
33925764	7	61	theme	Structural	1056:1065	arg1	characterization					1067:1082	Structural characterization	1056:1082	Structural characterization of lidocaine nanoemulsions as a function of water dilution	1056:1141	Structural characterization of lidocaine nanoemulsions as a function of water dilution was done using DSC.
33925764	6	62	dep	in	974:975	arg1	vitro					977:981	vitro	977:981	vitro	977:981	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	6	63	dep	type	913:916	arg1	concentration					938:950	concentration	938:950	concentration	938:950	In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated.
33925764	5	64	theme	nanoemulsion	735:746	arg1	template					748:755	nanoemulsion template	735:755	nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT)	735:847	Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT).
33925764	10	65	theme	transdermal	1497:1507	arg1	delivery					1514:1521	transdermal drug delivery	1497:1521	transdermal drug delivery	1497:1521	This extended-release profile is highly favorable in transdermal drug delivery and shows the great potential of this nanoemulsion as delivery system.
33925764	5	66	theme	ultrasound	800:809	arg1	approaches					786:795	combined approaches	777:795	combined approaches of ultrasound and phase inversion temperature (PIT)	777:847	Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT).
33925764	1	67	theme	anesthetic	201:210	arg1	delivery					212:219	local anesthetic delivery	195:219	local anesthetic delivery	195:219	Transdermal drug delivery of lidocaine is a good choice for local anesthetic delivery.
33925764	2	68	theme	great	248:252	arg1	effectiveness					254:266	great effectiveness	248:266	great effectiveness	248:266	Microemulsions have shown great effectiveness for the transdermal transport of lidocaine.
33925764	8	69	theme	<	1209:1209	arg1	nm					1215:1216	d < 150 nm	1207:1216	d < 150 nm	1207:1216	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	8	69	theme	<	1209:1209	arg1	diameters					1196:1204	small droplet diameters	1182:1204	small droplet diameters (d < 150 nm)	1182:1217	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	1	70	theme	Transdermal	135:145	arg1	delivery					152:159	Transdermal drug delivery	135:159	Transdermal drug delivery of lidocaine	135:172	Transdermal drug delivery of lidocaine is a good choice for local anesthetic delivery.
33925764	1	70	theme	Transdermal	135:145	arg1	choice					184:189	a good choice	177:189	a good choice for local anesthetic delivery	177:219	Transdermal drug delivery of lidocaine is a good choice for local anesthetic delivery.
33925764	8	71	theme	dynamic	1252:1258	arg1	scattering					1266:1275	dynamic light scattering	1252:1275	dynamic light scattering (DLS)	1252:1281	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	8	71	theme	dynamic	1252:1258	arg1	DLS					1278:1280	DLS	1278:1280	DLS	1278:1280	Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM.
33925764	10	72	from	favorable	1484:1492	arg1	delivery					1514:1521	transdermal drug delivery	1497:1521	transdermal drug delivery	1497:1521	This extended-release profile is highly favorable in transdermal drug delivery and shows the great potential of this nanoemulsion as delivery system.
33925764	0	73	dep	Fabrication	0:10	arg1	Influence					92:100	Influence	92:100	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.	0:133	Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant.
33925764	1	74	theme	drug	147:150	arg1	delivery					152:159	Transdermal drug delivery	135:159	Transdermal drug delivery of lidocaine	135:172	Transdermal drug delivery of lidocaine is a good choice for local anesthetic delivery.
33925764	1	74	theme	drug	147:150	arg1	choice					184:189	a good choice	177:189	a good choice for local anesthetic delivery	177:219	Transdermal drug delivery of lidocaine is a good choice for local anesthetic delivery.
33925764	5	75	theme	combined	777:784	arg1	approaches					786:795	combined approaches	777:795	combined approaches of ultrasound and phase inversion temperature (PIT)	777:847	Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT).
34762882	7	0	theme	alcohol	1159:1165	arg1	matrix					1181:1186	polyvinyl alcohol (PVA) polymer matrix	1149:1186	polyvinyl alcohol (PVA) polymer matrix with the linseed oil and lemon oil	1149:1221	The cellulose nanofibers were then incorporated into polyvinyl alcohol (PVA) polymer matrix with the linseed oil and lemon oil.
34762882	13	1	theme	45th	1868:1871	arg1	day					1873:1875	the 45th day	1864:1875	the 45th day	1864:1875	The film also exhibited excellent biodegradability; 87.34 ± 0.91% degradation was obtained on the 45th day.
34762882	2	2	theme	raw	354:356	arg1	material					358:365	raw material	354:365	raw material	354:365	Hence, in the present study, agro-waste (coconut shells) was selected as raw material to synthesize cellulose nanofibers, and it was incorporated into a biodegradable packaging film to enhance its properties.
34762882	2	2	theme	raw	354:356	arg1	agro-waste					310:319	agro-waste	310:319	agro-waste (coconut shells)	310:336	Hence, in the present study, agro-waste (coconut shells) was selected as raw material to synthesize cellulose nanofibers, and it was incorporated into a biodegradable packaging film to enhance its properties.
34762882	3	3	theme	%	702:702	arg1	yield					681:685	an excellent yield	668:685	an excellent yield of 41.67 ± 1.07%	668:702	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	10	4	from	preparation	1514:1524	arg1	industry					1558:1565	the food industry	1549:1565	the food industry	1549:1565	Hence, it can be used in the preparation of active packaging in the food industry.
34762882	4	5	theme	coconut	797:803	arg1	powder					811:816	the untreated coconut shell powder	783:816	the untreated coconut shell powder	783:816	After each treatment, the crystallinity index was improved, it was 74.38% for the untreated coconut shell powder, and 98.62% for the CNF obtained after ultra-sonication.
34762882	16	6	theme	bio	2113:2115	arg1	film					2131:2134	the prepared bio nanocomposite film	2100:2134	the prepared bio nanocomposite film	2100:2134	Hence, the prepared bio nanocomposite film is suggested as an alternative material for non-biodegradable food packaging, thereby reducing plastic pollution.
34762882	16	6	theme	bio	2113:2115	arg1	material					2167:2174	an alternative material	2152:2174	an alternative material for non-biodegradable food packaging	2152:2211	Hence, the prepared bio nanocomposite film is suggested as an alternative material for non-biodegradable food packaging, thereby reducing plastic pollution.
34762882	7	7	with	matrix	1181:1186	arg1	oil					1205:1207	the linseed oil	1193:1207	the linseed oil	1193:1207	The cellulose nanofibers were then incorporated into polyvinyl alcohol (PVA) polymer matrix with the linseed oil and lemon oil.
34762882	7	7	with	matrix	1181:1186	arg1	oil					1219:1221	lemon oil	1213:1221	lemon oil	1213:1221	The cellulose nanofibers were then incorporated into polyvinyl alcohol (PVA) polymer matrix with the linseed oil and lemon oil.
34762882	2	8	theme	coconut	322:328	arg1	agro-waste					310:319	agro-waste	310:319	agro-waste (coconut shells)	310:336	Hence, in the present study, agro-waste (coconut shells) was selected as raw material to synthesize cellulose nanofibers, and it was incorporated into a biodegradable packaging film to enhance its properties.
34762882	2	8	theme	coconut	322:328	arg1	shells					330:335	coconut shells	322:335	coconut shells	322:335	Hence, in the present study, agro-waste (coconut shells) was selected as raw material to synthesize cellulose nanofibers, and it was incorporated into a biodegradable packaging film to enhance its properties.
34762882	1	9	theme	synthetic	204:212	arg1	plastic					214:220	non-biodegradable synthetic plastic	186:220	non-biodegradable synthetic plastic	186:220	Environmental pollution due to the usage of non-biodegradable synthetic plastic and agro-waste disposal/burning are major issues nowadays.
34762882	0	10	theme	food	126:129	arg1	packaging					131:139	synthetic plastic food packaging	108:139	synthetic plastic food packaging	108:139	Biodegradable nano composite reinforced with cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging.
34762882	10	11	theme	active	1529:1534	arg1	packaging					1536:1544	active packaging	1529:1544	active packaging	1529:1544	Hence, it can be used in the preparation of active packaging in the food industry.
34762882	1	12	theme	disposal/burning	237:252	arg1	usage					177:181	the usage	173:181	the usage of non-biodegradable synthetic plastic and agro-waste disposal/burning	173:252	Environmental pollution due to the usage of non-biodegradable synthetic plastic and agro-waste disposal/burning are major issues nowadays.
34762882	9	13	theme	PVA-CNF-oil-based	1387:1403	arg1	film					1415:1418	PVA-CNF-oil-based composite film	1387:1418	PVA-CNF-oil-based composite film	1387:1418	Moreover, PVA-CNF-oil-based composite film showed good antimicrobial activity against food-borne pathogens.
34762882	13	14	theme	87.34 ± 0.91	1822:1833	arg1	%					1834:1834	%	1834:1834	%	1834:1834	The film also exhibited excellent biodegradability; 87.34 ± 0.91% degradation was obtained on the 45th day.
34762882	11	15	theme	quality	1661:1667	arg1	film					1683:1686	superior quality than neat PVA film	1652:1686	superior quality than neat PVA film	1652:1686	Similarly, the mechanical and thermal properties of bio nanocomposite film inferred superior quality than neat PVA film.
34762882	1	16	theme	Environmental	142:154	arg1	pollution					156:164	Environmental pollution	142:164	Environmental pollution due to the usage of non-biodegradable synthetic plastic and agro-waste disposal/burning	142:252	Environmental pollution due to the usage of non-biodegradable synthetic plastic and agro-waste disposal/burning are major issues nowadays.
34762882	16	17	theme	non-biodegradable	2180:2196	arg1	packaging					2203:2211	non-biodegradable food packaging	2180:2211	non-biodegradable food packaging	2180:2211	Hence, the prepared bio nanocomposite film is suggested as an alternative material for non-biodegradable food packaging, thereby reducing plastic pollution.
34762882	7	18	theme	polyvinyl	1149:1157	arg1	PVA					1168:1170	PVA	1168:1170	PVA	1168:1170	The cellulose nanofibers were then incorporated into polyvinyl alcohol (PVA) polymer matrix with the linseed oil and lemon oil.
34762882	7	18	theme	polyvinyl	1149:1157	arg1	alcohol					1159:1165	polyvinyl alcohol	1149:1165	polyvinyl alcohol (PVA) polymer matrix with the linseed oil and lemon oil	1149:1221	The cellulose nanofibers were then incorporated into polyvinyl alcohol (PVA) polymer matrix with the linseed oil and lemon oil.
34762882	9	19	theme	good	1427:1430	arg1	activity					1446:1453	good antimicrobial activity	1427:1453	good antimicrobial activity against food-borne pathogens	1427:1482	Moreover, PVA-CNF-oil-based composite film showed good antimicrobial activity against food-borne pathogens.
34762882	8	20	theme	essential	1228:1236	arg1	oil					1238:1240	The essential oil	1224:1240	The essential oil	1224:1240	The essential oil improved the antioxidant properties of PVA-CNF film, and free radicle scavenging activity was 31.52 ± 0.08% upon the addition of oils.
34762882	0	21	theme	industry	79:86	arg1	waste					88:92	cellulose nano fiber from coconut industry waste	45:92	cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging	45:139	Biodegradable nano composite reinforced with cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging.
34762882	4	22	theme	crystallinity	731:743	arg1	index					745:749	the crystallinity index	727:749	the crystallinity index	727:749	After each treatment, the crystallinity index was improved, it was 74.38% for the untreated coconut shell powder, and 98.62% for the CNF obtained after ultra-sonication.
34762882	14	23	theme	major	1886:1890	arg1	objective					1892:1900	Another major objective	1878:1900	Another major objective of the study	1878:1913	Another major objective of the study was to provide a hydrophobic nature to PVA-based film.
34762882	11	24	theme	neat	1674:1677	arg1	film					1683:1686	superior quality than neat PVA film	1652:1686	superior quality than neat PVA film	1652:1686	Similarly, the mechanical and thermal properties of bio nanocomposite film inferred superior quality than neat PVA film.
34762882	9	25	theme	food-borne	1463:1472	arg1	pathogens					1474:1482	food-borne pathogens	1463:1482	food-borne pathogens	1463:1482	Moreover, PVA-CNF-oil-based composite film showed good antimicrobial activity against food-borne pathogens.
34762882	8	26	theme	antioxidant	1255:1265	arg1	properties					1267:1276	the antioxidant properties	1251:1276	the antioxidant properties of PVA-CNF film	1251:1292	The essential oil improved the antioxidant properties of PVA-CNF film, and free radicle scavenging activity was 31.52 ± 0.08% upon the addition of oils.
34762882	0	27	theme	synthetic	108:116	arg1	packaging					131:139	synthetic plastic food packaging	108:139	synthetic plastic food packaging	108:139	Biodegradable nano composite reinforced with cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging.
34762882	14	28	theme	study	1909:1913	arg1	objective					1892:1900	Another major objective	1878:1900	Another major objective of the study	1878:1913	Another major objective of the study was to provide a hydrophobic nature to PVA-based film.
34762882	0	29	theme	Biodegradable	0:12	arg1	composite					19:27	Biodegradable nano composite	0:27	Biodegradable nano composite	0:27	Biodegradable nano composite reinforced with cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging.
34762882	2	30	theme	biodegradable	434:446	arg1	film					458:461	a biodegradable packaging film	432:461	a biodegradable packaging film to enhance its properties	432:487	Hence, in the present study, agro-waste (coconut shells) was selected as raw material to synthesize cellulose nanofibers, and it was incorporated into a biodegradable packaging film to enhance its properties.
34762882	8	31	theme	film	1289:1292	arg1	properties					1267:1276	the antioxidant properties	1251:1276	the antioxidant properties of PVA-CNF film	1251:1292	The essential oil improved the antioxidant properties of PVA-CNF film, and free radicle scavenging activity was 31.52 ± 0.08% upon the addition of oils.
34762882	5	32	theme	FTIR	902:905	arg1	analysis					907:914	FTIR analysis	902:914	FTIR analysis	902:914	After chemical treatments, FTIR analysis was done to confirm the removal of non-cellulosic material.
34762882	7	33	theme	lemon	1213:1217	arg1	oil					1219:1221	lemon oil	1213:1221	lemon oil	1213:1221	The cellulose nanofibers were then incorporated into polyvinyl alcohol (PVA) polymer matrix with the linseed oil and lemon oil.
34762882	3	34	theme	physical	627:634	arg1	methods					655:661	physical (ultra-sonication) methods	627:661	physical (ultra-sonication) methods	627:661	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	5	35	theme	material	966:973	arg1	removal					940:946	the removal	936:946	the removal of non-cellulosic material	936:973	After chemical treatments, FTIR analysis was done to confirm the removal of non-cellulosic material.
34762882	12	36	theme	developed	1719:1727	arg1	film					1729:1732	the developed film	1715:1732	the developed film	1715:1732	The optical properties of the developed film were on par with polyethylene film.
34762882	0	37	theme	from	66:69	arg1	waste					88:92	cellulose nano fiber from coconut industry waste	45:92	cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging	45:139	Biodegradable nano composite reinforced with cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging.
34762882	8	38	theme	radicle	1304:1310	arg1	activity					1323:1330	free radicle scavenging activity	1299:1330	free radicle scavenging activity	1299:1330	The essential oil improved the antioxidant properties of PVA-CNF film, and free radicle scavenging activity was 31.52 ± 0.08% upon the addition of oils.
34762882	3	39	theme	shell	498:502	arg1	CNF					526:528	CNF	526:528	CNF	526:528	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	3	39	theme	shell	498:502	arg1	nanofibers					514:523	Coconut shell cellulose nanofibers	490:523	Coconut shell cellulose nanofibers (CNF)	490:529	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	0	40	theme	nano	55:58	arg1	waste					88:92	cellulose nano fiber from coconut industry waste	45:92	cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging	45:139	Biodegradable nano composite reinforced with cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging.
34762882	14	41	theme	hydrophobic	1932:1942	arg1	nature					1944:1949	a hydrophobic nature	1930:1949	a hydrophobic nature to PVA-based film	1930:1967	Another major objective of the study was to provide a hydrophobic nature to PVA-based film.
34762882	3	42	theme	methods	655:661	arg1	combination					553:563	a combination	551:563	a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%	551:702	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	15	43	theme	coconut	2021:2027	arg1	nanofibers					2035:2044	coconut shell nanofibers	2021:2044	coconut shell nanofibers	2021:2044	It was improved by incorporating essential oil and coconut shell nanofibers; the contact angle measured was 91.3° ± 0.79°.
34762882	12	44	theme	optical	1693:1699	arg1	properties					1701:1710	The optical properties	1689:1710	The optical properties of the developed film	1689:1732	The optical properties of the developed film were on par with polyethylene film.
34762882	11	45	theme	bio	1620:1622	arg1	film					1638:1641	bio nanocomposite film	1620:1641	bio nanocomposite film	1620:1641	Similarly, the mechanical and thermal properties of bio nanocomposite film inferred superior quality than neat PVA film.
34762882	16	46	theme	prepared	2104:2111	arg1	film					2131:2134	the prepared bio nanocomposite film	2100:2134	the prepared bio nanocomposite film	2100:2134	Hence, the prepared bio nanocomposite film is suggested as an alternative material for non-biodegradable food packaging, thereby reducing plastic pollution.
34762882	16	46	theme	prepared	2104:2111	arg1	material					2167:2174	an alternative material	2152:2174	an alternative material for non-biodegradable food packaging	2152:2211	Hence, the prepared bio nanocomposite film is suggested as an alternative material for non-biodegradable food packaging, thereby reducing plastic pollution.
34762882	12	47	with	par	1742:1744	arg1	film					1764:1767	polyethylene film	1751:1767	polyethylene film	1751:1767	The optical properties of the developed film were on par with polyethylene film.
34762882	16	48	theme	nanocomposite	2117:2129	arg1	film					2131:2134	the prepared bio nanocomposite film	2100:2134	the prepared bio nanocomposite film	2100:2134	Hence, the prepared bio nanocomposite film is suggested as an alternative material for non-biodegradable food packaging, thereby reducing plastic pollution.
34762882	16	48	theme	nanocomposite	2117:2129	arg1	material					2167:2174	an alternative material	2152:2174	an alternative material for non-biodegradable food packaging	2152:2211	Hence, the prepared bio nanocomposite film is suggested as an alternative material for non-biodegradable food packaging, thereby reducing plastic pollution.
34762882	2	49	theme	present	295:301	arg1	study					303:307	the present study	291:307	the present study	291:307	Hence, in the present study, agro-waste (coconut shells) was selected as raw material to synthesize cellulose nanofibers, and it was incorporated into a biodegradable packaging film to enhance its properties.
34762882	15	50	theme	contact	2051:2057	arg1	angle					2059:2063	the contact angle	2047:2063	the contact angle measured	2047:2072	It was improved by incorporating essential oil and coconut shell nanofibers; the contact angle measured was 91.3° ± 0.79°.
34762882	4	51	theme	untreated	787:795	arg1	powder					811:816	the untreated coconut shell powder	783:816	the untreated coconut shell powder	783:816	After each treatment, the crystallinity index was improved, it was 74.38% for the untreated coconut shell powder, and 98.62% for the CNF obtained after ultra-sonication.
34762882	3	52	theme	mechanical	568:577	arg1	combination					553:563	a combination	551:563	a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%	551:702	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	1	53	theme	non-biodegradable	186:202	arg1	plastic					214:220	non-biodegradable synthetic plastic	186:220	non-biodegradable synthetic plastic	186:220	Environmental pollution due to the usage of non-biodegradable synthetic plastic and agro-waste disposal/burning are major issues nowadays.
34762882	4	54	theme	shell	805:809	arg1	powder					811:816	the untreated coconut shell powder	783:816	the untreated coconut shell powder	783:816	After each treatment, the crystallinity index was improved, it was 74.38% for the untreated coconut shell powder, and 98.62% for the CNF obtained after ultra-sonication.
34762882	1	55	theme	plastic	214:220	arg1	usage					177:181	the usage	173:181	the usage of non-biodegradable synthetic plastic and agro-waste disposal/burning	173:252	Environmental pollution due to the usage of non-biodegradable synthetic plastic and agro-waste disposal/burning are major issues nowadays.
34762882	10	56	theme	packaging	1536:1544	arg1	preparation					1514:1524	the preparation	1510:1524	the preparation of active packaging in the food industry	1510:1565	Hence, it can be used in the preparation of active packaging in the food industry.
34762882	1	57	theme	agro-waste	226:235	arg1	disposal/burning					237:252	agro-waste disposal/burning	226:252	agro-waste disposal/burning	226:252	Environmental pollution due to the usage of non-biodegradable synthetic plastic and agro-waste disposal/burning are major issues nowadays.
34762882	3	58	theme	ball	580:583	arg1	mechanical					568:577	mechanical	568:577	mechanical	568:577	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	3	58	theme	ball	580:583	arg1	milling					585:591	ball milling	580:591	ball milling	580:591	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	10	59	used	used	1502:1505	arg2	it					1492:1493	it	1492:1493	it	1492:1493	Hence, it can be used in the preparation of active packaging in the food industry.
34762882	8	60	theme	oils	1371:1374	arg1	addition					1359:1366	the addition	1355:1366	the addition of oils	1355:1374	The essential oil improved the antioxidant properties of PVA-CNF film, and free radicle scavenging activity was 31.52 ± 0.08% upon the addition of oils.
34762882	11	61	theme	film	1638:1641	arg1	properties					1606:1615	the mechanical and thermal properties	1579:1615	the mechanical and thermal properties of bio nanocomposite film	1579:1641	Similarly, the mechanical and thermal properties of bio nanocomposite film inferred superior quality than neat PVA film.
34762882	16	62	theme	food	2198:2201	arg1	packaging					2203:2211	non-biodegradable food packaging	2180:2211	non-biodegradable food packaging	2180:2211	Hence, the prepared bio nanocomposite film is suggested as an alternative material for non-biodegradable food packaging, thereby reducing plastic pollution.
34762882	3	63	theme	acid	605:608	arg1	hydrolysis					610:619	acid hydrolysis	605:619	acid hydrolysis	605:619	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	9	64	theme	composite	1405:1413	arg1	film					1415:1418	PVA-CNF-oil-based composite film	1387:1418	PVA-CNF-oil-based composite film	1387:1418	Moreover, PVA-CNF-oil-based composite film showed good antimicrobial activity against food-borne pathogens.
34762882	13	65	theme	%	1834:1834	arg1	degradation					1836:1846	87.34 ± 0.91% degradation	1822:1846	87.34 ± 0.91% degradation	1822:1846	The film also exhibited excellent biodegradability; 87.34 ± 0.91% degradation was obtained on the 45th day.
34762882	11	66	theme	than	1669:1672	arg1	film					1683:1686	superior quality than neat PVA film	1652:1686	superior quality than neat PVA film	1652:1686	Similarly, the mechanical and thermal properties of bio nanocomposite film inferred superior quality than neat PVA film.
34762882	0	67	theme	coconut	71:77	arg1	waste					88:92	cellulose nano fiber from coconut industry waste	45:92	cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging	45:139	Biodegradable nano composite reinforced with cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging.
34762882	16	68	theme	plastic	2231:2237	arg1	pollution					2239:2247	plastic pollution	2231:2247	plastic pollution	2231:2247	Hence, the prepared bio nanocomposite film is suggested as an alternative material for non-biodegradable food packaging, thereby reducing plastic pollution.
34762882	3	69	theme	chemical	595:602	arg1	combination					553:563	a combination	551:563	a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%	551:702	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	3	70	dep	chemical	595:602	arg1	hydrolysis					610:619	acid hydrolysis	605:619	acid hydrolysis	605:619	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	11	71	theme	superior	1652:1659	arg1	film					1683:1686	superior quality than neat PVA film	1652:1686	superior quality than neat PVA film	1652:1686	Similarly, the mechanical and thermal properties of bio nanocomposite film inferred superior quality than neat PVA film.
34762882	9	72	theme	antimicrobial	1432:1444	arg1	activity					1446:1453	good antimicrobial activity	1427:1453	good antimicrobial activity against food-borne pathogens	1427:1482	Moreover, PVA-CNF-oil-based composite film showed good antimicrobial activity against food-borne pathogens.
34762882	13	73	theme	excellent	1794:1802	arg1	biodegradability					1804:1819	excellent biodegradability	1794:1819	excellent biodegradability	1794:1819	The film also exhibited excellent biodegradability; 87.34 ± 0.91% degradation was obtained on the 45th day.
34762882	6	74	dep	structure	980:988	arg1	The					976:978	The	976:978	The	976:978	The structure and morphology of the nanofiber were concluded from SEM, AFM, TEM, and the size obtained was up to 29 nm.
34762882	11	75	theme	PVA	1679:1681	arg1	film					1683:1686	superior quality than neat PVA film	1652:1686	superior quality than neat PVA film	1652:1686	Similarly, the mechanical and thermal properties of bio nanocomposite film inferred superior quality than neat PVA film.
34762882	0	76	theme	plastic	118:124	arg1	packaging					131:139	synthetic plastic food packaging	108:139	synthetic plastic food packaging	108:139	Biodegradable nano composite reinforced with cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging.
34762882	10	77	theme	food	1553:1556	arg1	industry					1558:1565	the food industry	1549:1565	the food industry	1549:1565	Hence, it can be used in the preparation of active packaging in the food industry.
34762882	0	78	theme	nano	14:17	arg1	composite					19:27	Biodegradable nano composite	0:27	Biodegradable nano composite	0:27	Biodegradable nano composite reinforced with cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging.
34762882	5	79	theme	chemical	881:888	arg1	treatments					890:899	chemical treatments	881:899	chemical treatments	881:899	After chemical treatments, FTIR analysis was done to confirm the removal of non-cellulosic material.
34762882	6	80	theme	nanofiber	1012:1020	arg1	morphology					994:1003	morphology	994:1003	morphology	994:1003	The structure and morphology of the nanofiber were concluded from SEM, AFM, TEM, and the size obtained was up to 29 nm.
34762882	6	80	theme	nanofiber	1012:1020	arg1	structure					980:988	structure	980:988	structure	980:988	The structure and morphology of the nanofiber were concluded from SEM, AFM, TEM, and the size obtained was up to 29 nm.
34762882	2	81	theme	packaging	448:456	arg1	film					458:461	a biodegradable packaging film	432:461	a biodegradable packaging film to enhance its properties	432:487	Hence, in the present study, agro-waste (coconut shells) was selected as raw material to synthesize cellulose nanofibers, and it was incorporated into a biodegradable packaging film to enhance its properties.
34762882	3	82	theme	ultra-sonication	637:652	arg1	methods					655:661	physical (ultra-sonication) methods	627:661	physical (ultra-sonication) methods	627:661	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	16	83	theme	alternative	2155:2165	arg1	film					2131:2134	the prepared bio nanocomposite film	2100:2134	the prepared bio nanocomposite film	2100:2134	Hence, the prepared bio nanocomposite film is suggested as an alternative material for non-biodegradable food packaging, thereby reducing plastic pollution.
34762882	16	83	theme	alternative	2155:2165	arg1	material					2167:2174	an alternative material	2152:2174	an alternative material for non-biodegradable food packaging	2152:2211	Hence, the prepared bio nanocomposite film is suggested as an alternative material for non-biodegradable food packaging, thereby reducing plastic pollution.
34762882	2	84	theme	cellulose	381:389	arg1	nanofibers					391:400	cellulose nanofibers	381:400	cellulose nanofibers	381:400	Hence, in the present study, agro-waste (coconut shells) was selected as raw material to synthesize cellulose nanofibers, and it was incorporated into a biodegradable packaging film to enhance its properties.
34762882	11	85	theme	thermal	1598:1604	arg1	properties					1606:1615	the mechanical and thermal properties	1579:1615	the mechanical and thermal properties of bio nanocomposite film	1579:1641	Similarly, the mechanical and thermal properties of bio nanocomposite film inferred superior quality than neat PVA film.
34762882	8	86	theme	PVA-CNF	1281:1287	arg1	film					1289:1292	PVA-CNF film	1281:1292	PVA-CNF film	1281:1292	The essential oil improved the antioxidant properties of PVA-CNF film, and free radicle scavenging activity was 31.52 ± 0.08% upon the addition of oils.
34762882	0	87	theme	cellulose	45:53	arg1	waste					88:92	cellulose nano fiber from coconut industry waste	45:92	cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging	45:139	Biodegradable nano composite reinforced with cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging.
34762882	15	88	theme	shell	2029:2033	arg1	nanofibers					2035:2044	coconut shell nanofibers	2021:2044	coconut shell nanofibers	2021:2044	It was improved by incorporating essential oil and coconut shell nanofibers; the contact angle measured was 91.3° ± 0.79°.
34762882	5	89	theme	non-cellulosic	951:964	arg1	material					966:973	non-cellulosic material	951:973	non-cellulosic material	951:973	After chemical treatments, FTIR analysis was done to confirm the removal of non-cellulosic material.
34762882	7	90	theme	linseed	1197:1203	arg1	oil					1205:1207	the linseed oil	1193:1207	the linseed oil	1193:1207	The cellulose nanofibers were then incorporated into polyvinyl alcohol (PVA) polymer matrix with the linseed oil and lemon oil.
34762882	14	91	theme	PVA-based	1954:1962	arg1	film					1964:1967	PVA-based film	1954:1967	PVA-based film	1954:1967	Another major objective of the study was to provide a hydrophobic nature to PVA-based film.
34762882	11	92	theme	mechanical	1583:1592	arg1	properties					1606:1615	the mechanical and thermal properties	1579:1615	the mechanical and thermal properties of bio nanocomposite film	1579:1641	Similarly, the mechanical and thermal properties of bio nanocomposite film inferred superior quality than neat PVA film.
34762882	7	93	theme	cellulose	1100:1108	arg1	nanofibers					1110:1119	The cellulose nanofibers	1096:1119	The cellulose nanofibers	1096:1119	The cellulose nanofibers were then incorporated into polyvinyl alcohol (PVA) polymer matrix with the linseed oil and lemon oil.
34762882	0	94	theme	fiber	60:64	arg1	waste					88:92	cellulose nano fiber from coconut industry waste	45:92	cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging	45:139	Biodegradable nano composite reinforced with cellulose nano fiber from coconut industry waste for replacing synthetic plastic food packaging.
34762882	15	95	theme	essential	2003:2011	arg1	oil					2013:2015	essential oil	2003:2015	essential oil	2003:2015	It was improved by incorporating essential oil and coconut shell nanofibers; the contact angle measured was 91.3° ± 0.79°.
34762882	11	96	theme	nanocomposite	1624:1636	arg1	film					1638:1641	bio nanocomposite film	1620:1641	bio nanocomposite film	1620:1641	Similarly, the mechanical and thermal properties of bio nanocomposite film inferred superior quality than neat PVA film.
34762882	8	97	theme	free	1299:1302	arg1	activity					1323:1330	free radicle scavenging activity	1299:1330	free radicle scavenging activity	1299:1330	The essential oil improved the antioxidant properties of PVA-CNF film, and free radicle scavenging activity was 31.52 ± 0.08% upon the addition of oils.
34762882	3	98	theme	cellulose	504:512	arg1	CNF					526:528	CNF	526:528	CNF	526:528	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	3	98	theme	cellulose	504:512	arg1	nanofibers					514:523	Coconut shell cellulose nanofibers	490:523	Coconut shell cellulose nanofibers (CNF)	490:529	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	12	99	theme	polyethylene	1751:1762	arg1	film					1764:1767	polyethylene film	1751:1767	polyethylene film	1751:1767	The optical properties of the developed film were on par with polyethylene film.
34762882	12	100	theme	film	1729:1732	arg1	properties					1701:1710	The optical properties	1689:1710	The optical properties of the developed film	1689:1732	The optical properties of the developed film were on par with polyethylene film.
34762882	7	101	theme	polymer	1173:1179	arg1	matrix					1181:1186	polyvinyl alcohol (PVA) polymer matrix	1149:1186	polyvinyl alcohol (PVA) polymer matrix with the linseed oil and lemon oil	1149:1221	The cellulose nanofibers were then incorporated into polyvinyl alcohol (PVA) polymer matrix with the linseed oil and lemon oil.
34762882	8	102	theme	scavenging	1312:1321	arg1	activity					1323:1330	free radicle scavenging activity	1299:1330	free radicle scavenging activity	1299:1330	The essential oil improved the antioxidant properties of PVA-CNF film, and free radicle scavenging activity was 31.52 ± 0.08% upon the addition of oils.
34762882	3	103	theme	Coconut	490:496	arg1	CNF					526:528	CNF	526:528	CNF	526:528	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	3	103	theme	Coconut	490:496	arg1	nanofibers					514:523	Coconut shell cellulose nanofibers	490:523	Coconut shell cellulose nanofibers (CNF)	490:529	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	1	104	theme	major	258:262	arg1	issues					264:269	major issues	258:269	major issues	258:269	Environmental pollution due to the usage of non-biodegradable synthetic plastic and agro-waste disposal/burning are major issues nowadays.
34762882	3	105	theme	excellent	671:679	arg1	yield					681:685	an excellent yield	668:685	an excellent yield of 41.67 ± 1.07%	668:702	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34762882	3	106	with	combination	553:563	arg1	yield					681:685	an excellent yield	668:685	an excellent yield of 41.67 ± 1.07%	668:702	Coconut shell cellulose nanofibers (CNF) were synthesized by a combination of mechanical (ball milling), chemical (acid hydrolysis), and physical (ultra-sonication) methods with an excellent yield of 41.67 ± 1.07%.
34126012	1	0	theme	stability	303:311	arg1	loss					284:287	a loss	282:287	a loss of mechanical stability	282:311	We present an alternative to commonly used, but from an environmental point of view, problematic wet strength agents, which are usually added to paper to prevent a loss of mechanical stability and finally disintegrate when they get into contact with water.
34126012	1	0	theme	stability	303:311	arg1	disintegrate					325:336	disintegrate	325:336	disintegrate	325:336	We present an alternative to commonly used, but from an environmental point of view, problematic wet strength agents, which are usually added to paper to prevent a loss of mechanical stability and finally disintegrate when they get into contact with water.
34126012	7	1	theme	samples	1439:1445	arg1	indices					1398:1404	the tensile indices	1386:1404	the tensile indices of the modified and wetted paper samples	1386:1445	Initial experiments show that the tensile indices of the modified and wetted paper samples are up to 50 times higher compared to the values measured for unmodified samples.
34126012	7	1	theme	samples	1439:1445	arg1	higher					1466:1471	higher	1466:1471	higher	1466:1471	Initial experiments show that the tensile indices of the modified and wetted paper samples are up to 50 times higher compared to the values measured for unmodified samples.
34126012	1	2	theme	used	158:161	arg1	agents					230:235	commonly used, but from an environmental point of view, problematic wet strength agents	149:235	commonly used, but from an environmental point of view, problematic wet strength agents	149:235	We present an alternative to commonly used, but from an environmental point of view, problematic wet strength agents, which are usually added to paper to prevent a loss of mechanical stability and finally disintegrate when they get into contact with water.
34126012	4	3	theme	cross-linker	1016:1027	arg1	composition					1029:1039	cross-linker composition	1016:1039	cross-linker composition	1016:1039	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	4	4	theme	model	891:895	arg1	surface					897:903	a cellulose model surface	879:903	a cellulose model surface	879:903	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	2	5	theme	carbene	547:553	arg1	intermediates					555:567	carbene intermediates	547:567	carbene intermediates	547:567	To this end, diazoester-containing copolymers are generated, which are coated onto paper and by heating to 110-160 °C for short periods of time become activated and form carbene intermediates, which undergo a CH-insertion cross-linking reaction.
34126012	6	6	theme	paper	1338:1342	arg1	substrates					1344:1353	paper substrates	1338:1353	paper substrates	1338:1353	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	0	7	theme	CH-Insertion	92:103	arg1	Cross-Linking					105:117	Thermally Induced CH-Insertion Cross-Linking	74:117	Thermally Induced CH-Insertion Cross-Linking	74:117	Diazo-Based Copolymers for the Wet Strength Improvement of Paper Based on Thermally Induced CH-Insertion Cross-Linking.
34126012	3	8	theme	simultaneous	646:657	arg1	cross-linking					659:671	a simultaneous cross-linking	644:671	a simultaneous cross-linking of the polymer	644:686	The process leads to a simultaneous cross-linking of the polymer and its attachment to the cellulose substrate.
34126012	4	9	theme	diazoester-based	849:864	arg1	comonomer					866:874	a diazoester-based comonomer	847:874	a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates	847:958	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	7	10	theme	Initial	1356:1362	arg1	experiments					1364:1374	Initial experiments	1356:1374	Initial experiments	1356:1374	Initial experiments show that the tensile indices of the modified and wetted paper samples are up to 50 times higher compared to the values measured for unmodified samples.
34126012	6	11	link	cross-linked	1291:1302	arg1	copolymers					1304:1313	the thermally cross-linked copolymers	1277:1313	the thermally cross-linked copolymers	1277:1313	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	8	12	theme	relative	1614:1621	arg1	strengths					1627:1635	relative wet strengths	1614:1635	relative wet strengths of over 30%	1614:1647	When dry and wet papers coated with the above-described wetting agents are compared, relative wet strengths of over 30% are observed.
34126012	0	13	theme	Induced	84:90	arg1	Cross-Linking					105:117	Thermally Induced CH-Insertion Cross-Linking	74:117	Thermally Induced CH-Insertion Cross-Linking	74:117	Diazo-Based Copolymers for the Wet Strength Improvement of Paper Based on Thermally Induced CH-Insertion Cross-Linking.
34126012	7	14	theme	paper	1433:1437	arg1	samples					1439:1445	wetted paper samples	1426:1445	wetted paper samples	1426:1445	Initial experiments show that the tensile indices of the modified and wetted paper samples are up to 50 times higher compared to the values measured for unmodified samples.
34126012	2	15	theme	cross-linking	599:611	arg1	reaction					613:620	a CH-insertion cross-linking reaction	584:620	a CH-insertion cross-linking reaction	584:620	To this end, diazoester-containing copolymers are generated, which are coated onto paper and by heating to 110-160 °C for short periods of time become activated and form carbene intermediates, which undergo a CH-insertion cross-linking reaction.
34126012	6	16	theme	tensile	1159:1165	arg1	properties					1167:1176	the tensile properties	1155:1176	the tensile properties of modified wet and dry eucalyptus sulfate papers	1155:1226	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	4	17	theme	paper	943:947	arg1	substrates					949:958	laboratory-engineered, fibrous paper substrates	912:958	laboratory-engineered, fibrous paper substrates	912:958	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	2	18	theme	CH-insertion	586:597	arg1	reaction					613:620	a CH-insertion cross-linking reaction	584:620	a CH-insertion cross-linking reaction	584:620	To this end, diazoester-containing copolymers are generated, which are coated onto paper and by heating to 110-160 °C for short periods of time become activated and form carbene intermediates, which undergo a CH-insertion cross-linking reaction.
34126012	4	19	theme	immobilization	739:752	arg1	process					754:760	The immobilization process	735:760	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates	735:958	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	4	19	theme	immobilization	739:752	arg1	function					981:988	a function	979:988	a function of time, temperature, and cross-linker composition	979:1039	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	8	20	theme	wetting	1585:1591	arg1	agents					1593:1598	the above-described wetting agents	1565:1598	the above-described wetting agents	1565:1598	When dry and wet papers coated with the above-described wetting agents are compared, relative wet strengths of over 30% are observed.
34126012	5	21	theme	fiber	1081:1085	arg1	network					1087:1093	the fiber network	1077:1093	the fiber network	1077:1093	The distribution of the polymer in the fiber network is studied using confocal fluorescence microscopy.
34126012	5	22	from	distribution	1046:1057	arg1	network					1087:1093	the fiber network	1077:1093	the fiber network	1077:1093	The distribution of the polymer in the fiber network is studied using confocal fluorescence microscopy.
34126012	4	23	theme	temperature	999:1009	arg1	process					754:760	The immobilization process	735:760	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates	735:958	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	4	23	theme	temperature	999:1009	arg1	function					981:988	a function	979:988	a function of time, temperature, and cross-linker composition	979:1039	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	3	24	theme	polymer	680:686	arg1	cross-linking					659:671	a simultaneous cross-linking	644:671	a simultaneous cross-linking of the polymer	644:686	The process leads to a simultaneous cross-linking of the polymer and its attachment to the cellulose substrate.
34126012	3	24	theme	polymer	680:686	arg1	attachment					696:705	its attachment	692:705	its attachment to the cellulose substrate	692:732	The process leads to a simultaneous cross-linking of the polymer and its attachment to the cellulose substrate.
34126012	1	25	dep	used	158:161	arg1	problematic					205:215	problematic	205:215	problematic	205:215	We present an alternative to commonly used, but from an environmental point of view, problematic wet strength agents, which are usually added to paper to prevent a loss of mechanical stability and finally disintegrate when they get into contact with water.
34126012	6	26	theme	cross-linked	1291:1302	arg1	copolymers					1304:1313	the thermally cross-linked copolymers	1277:1313	the thermally cross-linked copolymers	1277:1313	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	0	27	theme	Diazo-Based	0:10	arg1	Copolymers					12:21	Diazo-Based Copolymers	0:21	Diazo-Based Copolymers for the Wet Strength Improvement of Paper	0:63	Diazo-Based Copolymers for the Wet Strength Improvement of Paper Based on Thermally Induced CH-Insertion Cross-Linking.
34126012	6	28	theme	wet	1322:1324	arg1	strength					1326:1333	the wet strength	1318:1333	the wet strength of paper substrates	1318:1353	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	1	29	theme	environmental	176:188	arg1	point					190:194	an environmental point	173:194	an environmental point of view	173:202	We present an alternative to commonly used, but from an environmental point of view, problematic wet strength agents, which are usually added to paper to prevent a loss of mechanical stability and finally disintegrate when they get into contact with water.
34126012	2	30	theme	diazoester-containing	390:410	arg1	copolymers					412:421	diazoester-containing copolymers	390:421	diazoester-containing copolymers	390:421	To this end, diazoester-containing copolymers are generated, which are coated onto paper and by heating to 110-160 °C for short periods of time become activated and form carbene intermediates, which undergo a CH-insertion cross-linking reaction.
34126012	3	31	theme	cellulose	714:722	arg1	substrate					724:732	the cellulose substrate	710:732	the cellulose substrate	710:732	The process leads to a simultaneous cross-linking of the polymer and its attachment to the cellulose substrate.
34126012	6	32	theme	dry	1198:1200	arg1	sulfate					1213:1219	dry eucalyptus sulfate	1198:1219	dry eucalyptus sulfate	1198:1219	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	1	33	theme	point	190:194	arg1	agents					230:235	commonly used, but from an environmental point of view, problematic wet strength agents	149:235	commonly used, but from an environmental point of view, problematic wet strength agents	149:235	We present an alternative to commonly used, but from an environmental point of view, problematic wet strength agents, which are usually added to paper to prevent a loss of mechanical stability and finally disintegrate when they get into contact with water.
34126012	2	34	theme	short	499:503	arg1	periods					505:511	short periods	499:511	short periods of time	499:519	To this end, diazoester-containing copolymers are generated, which are coated onto paper and by heating to 110-160 °C for short periods of time become activated and form carbene intermediates, which undergo a CH-insertion cross-linking reaction.
34126012	7	35	theme	unmodified	1509:1518	arg1	samples					1520:1526	unmodified samples	1509:1526	unmodified samples	1509:1526	Initial experiments show that the tensile indices of the modified and wetted paper samples are up to 50 times higher compared to the values measured for unmodified samples.
34126012	7	36	theme	tensile	1390:1396	arg1	indices					1398:1404	the tensile indices	1386:1404	the tensile indices of the modified and wetted paper samples	1386:1445	Initial experiments show that the tensile indices of the modified and wetted paper samples are up to 50 times higher compared to the values measured for unmodified samples.
34126012	7	36	theme	tensile	1390:1396	arg1	higher					1466:1471	higher	1466:1471	higher	1466:1471	Initial experiments show that the tensile indices of the modified and wetted paper samples are up to 50 times higher compared to the values measured for unmodified samples.
34126012	0	37	theme	Strength	35:42	arg1	Improvement					44:54	the Wet Strength Improvement	27:54	the Wet Strength Improvement of Paper	27:63	Diazo-Based Copolymers for the Wet Strength Improvement of Paper Based on Thermally Induced CH-Insertion Cross-Linking.
34126012	7	38	dep	50	1457:1458	arg1	to					1454:1455	to	1454:1455	to	1454:1455	Initial experiments show that the tensile indices of the modified and wetted paper samples are up to 50 times higher compared to the values measured for unmodified samples.
34126012	6	39	theme	papers	1221:1226	arg1	properties					1167:1176	the tensile properties	1155:1176	the tensile properties of modified wet and dry eucalyptus sulfate papers	1155:1226	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	1	40	with	contact	357:363	arg1	water					370:374	water	370:374	water	370:374	We present an alternative to commonly used, but from an environmental point of view, problematic wet strength agents, which are usually added to paper to prevent a loss of mechanical stability and finally disintegrate when they get into contact with water.
34126012	1	41	theme	view	199:202	arg1	point					190:194	an environmental point	173:194	an environmental point of view	173:202	We present an alternative to commonly used, but from an environmental point of view, problematic wet strength agents, which are usually added to paper to prevent a loss of mechanical stability and finally disintegrate when they get into contact with water.
34126012	0	42	theme	Wet	31:33	arg1	Improvement					44:54	the Wet Strength Improvement	27:54	the Wet Strength Improvement of Paper	27:63	Diazo-Based Copolymers for the Wet Strength Improvement of Paper Based on Thermally Induced CH-Insertion Cross-Linking.
34126012	5	43	theme	fluorescence	1121:1132	arg1	microscopy					1134:1143	confocal fluorescence microscopy	1112:1143	confocal fluorescence microscopy	1112:1143	The distribution of the polymer in the fiber network is studied using confocal fluorescence microscopy.
34126012	4	44	dep	laboratory-engineered	912:932	arg1	fibrous					935:941	fibrous	935:941	fibrous	935:941	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	6	45	theme	sulfate	1213:1219	arg1	papers					1221:1226	modified wet and dry eucalyptus sulfate papers	1181:1226	modified wet and dry eucalyptus sulfate papers	1181:1226	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	4	46	theme	time	993:996	arg1	process					754:760	The immobilization process	735:760	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates	735:958	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	4	46	theme	time	993:996	arg1	function					981:988	a function	979:988	a function of time, temperature, and cross-linker composition	979:1039	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	8	47	theme	wet	1542:1544	arg1	papers					1546:1551	dry and wet papers	1534:1551	dry and wet papers coated with the above-described wetting agents	1534:1598	When dry and wet papers coated with the above-described wetting agents are compared, relative wet strengths of over 30% are observed.
34126012	6	48	theme	copolymers	1304:1313	arg1	effect					1267:1272	the strong effect	1256:1272	the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates	1256:1353	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	5	49	theme	polymer	1066:1072	arg1	distribution					1046:1057	The distribution	1042:1057	The distribution of the polymer in the fiber network	1042:1093	The distribution of the polymer in the fiber network is studied using confocal fluorescence microscopy.
34126012	6	50	theme	eucalyptus	1202:1211	arg1	sulfate					1213:1219	dry eucalyptus sulfate	1198:1219	dry eucalyptus sulfate	1198:1219	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	4	51	theme	cellulose	881:889	arg1	surface					897:903	a cellulose model surface	879:903	a cellulose model surface	879:903	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	5	52	theme	confocal	1112:1119	arg1	microscopy					1134:1143	confocal fluorescence microscopy	1112:1143	confocal fluorescence microscopy	1112:1143	The distribution of the polymer in the fiber network is studied using confocal fluorescence microscopy.
34126012	2	53	dep	coated	448:453	arg1	become					521:526	become	521:526	become activated	521:536	To this end, diazoester-containing copolymers are generated, which are coated onto paper and by heating to 110-160 °C for short periods of time become activated and form carbene intermediates, which undergo a CH-insertion cross-linking reaction.
34126012	8	54	theme	dry	1534:1536	arg1	papers					1546:1551	dry and wet papers	1534:1551	dry and wet papers coated with the above-described wetting agents	1534:1598	When dry and wet papers coated with the above-described wetting agents are compared, relative wet strengths of over 30% are observed.
34126012	4	55	theme	hydrophilic	792:802	arg1	matrix					804:809	a hydrophilic matrix	790:809	a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates	790:958	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	6	56	theme	strong	1260:1265	arg1	effect					1267:1272	the strong effect	1256:1272	the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates	1256:1353	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	2	57	theme	time	516:519	arg1	periods					505:511	short periods	499:511	short periods of time	499:519	To this end, diazoester-containing copolymers are generated, which are coated onto paper and by heating to 110-160 °C for short periods of time become activated and form carbene intermediates, which undergo a CH-insertion cross-linking reaction.
34126012	7	58	theme	the	1409:1411	arg1	indices					1398:1404	the tensile indices	1386:1404	the tensile indices of the modified and wetted paper samples	1386:1445	Initial experiments show that the tensile indices of the modified and wetted paper samples are up to 50 times higher compared to the values measured for unmodified samples.
34126012	7	58	theme	the	1409:1411	arg1	higher					1466:1471	higher	1466:1471	higher	1466:1471	Initial experiments show that the tensile indices of the modified and wetted paper samples are up to 50 times higher compared to the values measured for unmodified samples.
34126012	8	59	theme	wet	1623:1625	arg1	strengths					1627:1635	relative wet strengths	1614:1635	relative wet strengths of over 30%	1614:1647	When dry and wet papers coated with the above-described wetting agents are compared, relative wet strengths of over 30% are observed.
34126012	8	60	theme	above-described	1569:1583	arg1	agents					1593:1598	the above-described wetting agents	1565:1598	the above-described wetting agents	1565:1598	When dry and wet papers coated with the above-described wetting agents are compared, relative wet strengths of over 30% are observed.
34126012	3	61	attach	attachment	696:705	arg2	polymer					680:686	the polymer	676:686	the polymer	676:686	The process leads to a simultaneous cross-linking of the polymer and its attachment to the cellulose substrate.
34126012	3	61	attach	attachment	696:705	arg1	substrate					724:732	the cellulose substrate	710:732	the cellulose substrate	710:732	The process leads to a simultaneous cross-linking of the polymer and its attachment to the cellulose substrate.
34126012	6	62	theme	wet	1190:1192	arg1	papers					1221:1226	modified wet and dry eucalyptus sulfate papers	1181:1226	modified wet and dry eucalyptus sulfate papers	1181:1226	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	6	63	theme	substrates	1344:1353	arg1	strength					1326:1333	the wet strength	1318:1333	the wet strength of paper substrates	1318:1353	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	1	64	theme	wet	217:219	arg1	agents					230:235	commonly used, but from an environmental point of view, problematic wet strength agents	149:235	commonly used, but from an environmental point of view, problematic wet strength agents	149:235	We present an alternative to commonly used, but from an environmental point of view, problematic wet strength agents, which are usually added to paper to prevent a loss of mechanical stability and finally disintegrate when they get into contact with water.
34126012	7	65	theme	wetted	1426:1431	arg1	samples					1439:1445	wetted paper samples	1426:1445	wetted paper samples	1426:1445	Initial experiments show that the tensile indices of the modified and wetted paper samples are up to 50 times higher compared to the values measured for unmodified samples.
34126012	6	66	theme	modified	1181:1188	arg1	papers					1221:1226	modified wet and dry eucalyptus sulfate papers	1181:1226	modified wet and dry eucalyptus sulfate papers	1181:1226	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	8	67	theme	%	1647:1647	arg1	strengths					1627:1635	relative wet strengths	1614:1635	relative wet strengths of over 30%	1614:1647	When dry and wet papers coated with the above-described wetting agents are compared, relative wet strengths of over 30% are observed.
34126012	6	68	from	effect	1267:1272	arg1	strength					1326:1333	the wet strength	1318:1333	the wet strength of paper substrates	1318:1353	Finally, the tensile properties of modified wet and dry eucalyptus sulfate papers are measured to demonstrate the strong effect of the thermally cross-linked copolymers on the wet strength of paper substrates.
34126012	1	69	theme	strength	221:228	arg1	agents					230:235	commonly used, but from an environmental point of view, problematic wet strength agents	149:235	commonly used, but from an environmental point of view, problematic wet strength agents	149:235	We present an alternative to commonly used, but from an environmental point of view, problematic wet strength agents, which are usually added to paper to prevent a loss of mechanical stability and finally disintegrate when they get into contact with water.
34126012	0	70	theme	Paper	59:63	arg1	Improvement					44:54	the Wet Strength Improvement	27:54	the Wet Strength Improvement of Paper	27:63	Diazo-Based Copolymers for the Wet Strength Improvement of Paper Based on Thermally Induced CH-Insertion Cross-Linking.
34126012	1	71	theme	mechanical	292:301	arg1	stability					303:311	mechanical stability	292:311	mechanical stability	292:311	We present an alternative to commonly used, but from an environmental point of view, problematic wet strength agents, which are usually added to paper to prevent a loss of mechanical stability and finally disintegrate when they get into contact with water.
34126012	4	72	theme	copolymers	765:774	arg1	process					754:760	The immobilization process	735:760	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates	735:958	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	4	72	theme	copolymers	765:774	arg1	function					981:988	a function	979:988	a function of time, temperature, and cross-linker composition	979:1039	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	4	73	theme	composition	1029:1039	arg1	process					754:760	The immobilization process	735:760	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates	735:958	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	4	73	theme	composition	1029:1039	arg1	function					981:988	a function	979:988	a function of time, temperature, and cross-linker composition	979:1039	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
34126012	4	74	theme	laboratory-engineered	912:932	arg1	substrates					949:958	laboratory-engineered, fibrous paper substrates	912:958	laboratory-engineered, fibrous paper substrates	912:958	The immobilization process of copolymers consisting of a hydrophilic matrix based on N,N-dimethylacrylamide and a diazoester-based comonomer to a cellulose model surface and to laboratory-engineered, fibrous paper substrates is investigated as a function of time, temperature, and cross-linker composition.
33139538	7	0	theme	glycosyltransferase	1309:1327	arg1	activities					1329:1338	two of the glycosyltransferase activities	1298:1338	two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1	1298:1424	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	6	1	dep	methylated	1247:1256	arg1	O-2					1243:1245	O-2	1243:1245	O-2	1243:1245	We also establish that methylation of the C-3 hydroxyl group of the terminal α-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methylated substrate.
33139538	5	2	theme	C-2	1028:1030	arg1	group					1041:1045	the C-2 hydroxyl group	1024:1045	the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit	1024:1085	Here, we demonstrate that: domain 1 is a β-l-rhamnosyltransferase; domain 2 is an α-l-rhamnosyltransferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit.
33139538	5	2	theme	C-2	1028:1030	arg1	unit					1082:1085	the terminal α-l-rhamnose (Rha) unit	1050:1085	the terminal α-l-rhamnose (Rha) unit	1050:1085	Here, we demonstrate that: domain 1 is a β-l-rhamnosyltransferase; domain 2 is an α-l-rhamnosyltransferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit.
33139538	4	3	with	glycosyltransferase	732:750	arg1	each					777:780	each	777:780	each	777:780	Previous data collected from 20 PBCV-1 spontaneous mutants (or antigenic variants) suggested that the a064r gene encodes a glycosyltransferase (GT) with three domains, each with a different function.
33139538	4	3	with	glycosyltransferase	732:750	arg1	domains					768:774	three domains	762:774	three domains	762:774	Previous data collected from 20 PBCV-1 spontaneous mutants (or antigenic variants) suggested that the a064r gene encodes a glycosyltransferase (GT) with three domains, each with a different function.
33139538	0	4	theme	necessary	73:81	arg1	activities					62:71	the transferase activities	46:71	the transferase activities necessary to synthesize its capsid protein N-linked glycans	46:131	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	1	5	dep	alga	261:264	arg1	NC64A					287:291	Chlorella variabilis NC64A	266:291	the unicellular green alga Chlorella variabilis NC64A	239:291	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	6	6	theme	methylated	1247:1256	arg1	substrate					1258:1266	an O-2 methylated substrate	1240:1266	an O-2 methylated substrate	1240:1266	We also establish that methylation of the C-3 hydroxyl group of the terminal α-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methylated substrate.
33139538	6	7	theme	α-l-Rha	1165:1171	arg1	group					1143:1147	the C-3 hydroxyl group	1126:1147	the C-3 hydroxyl group of the terminal α-l-Rha	1126:1171	We also establish that methylation of the C-3 hydroxyl group of the terminal α-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methylated substrate.
33139538	6	7	theme	α-l-Rha	1165:1171	arg1	α-l-Rha					1165:1171	the terminal α-l-Rha	1152:1171	the terminal α-l-Rha	1152:1171	We also establish that methylation of the C-3 hydroxyl group of the terminal α-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methylated substrate.
33139538	7	8	theme	protein	1456:1462	arg1	A064R					1464:1468	a single protein A064R	1447:1468	a single protein A064R	1447:1468	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	7	9	theme	N-glycan	1373:1380	arg1	synthesis					1356:1364	the synthesis	1352:1364	the synthesis of the N-glycan of the viral major capsid protein in PBCV-1	1352:1424	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	2	10	attach	attached	410:417	arg2	glycans					402:408	the glycans	398:408	the glycans attached to its major capsid protein	398:445	Unlike many other viruses, PBCV-1 encodes most, if not all, of the enzymes involved in the synthesis of the glycans attached to its major capsid protein.
33139538	2	10	attach	attached	410:417	arg1	protein					439:445	its major capsid protein	422:445	its major capsid protein	422:445	Unlike many other viruses, PBCV-1 encodes most, if not all, of the enzymes involved in the synthesis of the glycans attached to its major capsid protein.
33139538	8	11	attach	attached	1597:1604	arg2	fragment					1581:1588	this fragment	1576:1588	this fragment	1576:1588	Remarkably, this fragment can be attached to any xylose unit.
33139538	8	11	attach	attached	1597:1604	arg1	unit					1620:1623	any xylose unit	1609:1623	any xylose unit	1609:1623	Remarkably, this fragment can be attached to any xylose unit.
33139538	1	12	theme	unicellular	243:253	arg1	alga					261:264	the unicellular green alga	239:264	the unicellular green alga Chlorella variabilis NC64A	239:291	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	4	13	theme	antigenic	672:680	arg1	variants					682:689	antigenic variants	672:689	antigenic variants	672:689	Previous data collected from 20 PBCV-1 spontaneous mutants (or antigenic variants) suggested that the a064r gene encodes a glycosyltransferase (GT) with three domains, each with a different function.
33139538	4	13	theme	antigenic	672:680	arg1	mutants					660:666	20 PBCV-1 spontaneous mutants	638:666	20 PBCV-1 spontaneous mutants (or antigenic variants)	638:690	Previous data collected from 20 PBCV-1 spontaneous mutants (or antigenic variants) suggested that the a064r gene encodes a glycosyltransferase (GT) with three domains, each with a different function.
33139538	4	14	theme	different	789:797	arg1	function					799:806	a different function	787:806	a different function	787:806	Previous data collected from 20 PBCV-1 spontaneous mutants (or antigenic variants) suggested that the a064r gene encodes a glycosyltransferase (GT) with three domains, each with a different function.
33139538	0	15	contain	has	33:35	arg2	three					37:41	three	37:41	three	37:41	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	0	15	contain	has	33:35	arg1	A064R					27:31	Chlorovirus PBCV-1 protein A064R	0:31	Chlorovirus PBCV-1 protein A064R	0:31	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	0	15	contain	has	33:35	arg2	activities					62:71	the transferase activities	46:71	the transferase activities necessary to synthesize its capsid protein N-linked glycans	46:131	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	1	16	theme	green	255:259	arg1	alga					261:264	the unicellular green alga	239:264	the unicellular green alga Chlorella variabilis NC64A	239:291	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	0	17	theme	protein	108:114	arg1	glycans					125:131	its capsid protein N-linked glycans	97:131	its capsid protein N-linked glycans	97:131	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	6	18	theme	terminal	1156:1163	arg1	α-l-Rha					1165:1171	the terminal α-l-Rha	1152:1171	the terminal α-l-Rha	1152:1171	We also establish that methylation of the C-3 hydroxyl group of the terminal α-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methylated substrate.
33139538	7	19	theme	of	1302:1303	arg1	activities					1329:1338	two of the glycosyltransferase activities	1298:1338	two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1	1298:1424	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	2	20	dep	not	345:347	arg1	if					342:343	if	342:343	if	342:343	Unlike many other viruses, PBCV-1 encodes most, if not all, of the enzymes involved in the synthesis of the glycans attached to its major capsid protein.
33139538	8	21	theme	xylose	1613:1618	arg1	unit					1620:1623	any xylose unit	1609:1623	any xylose unit	1609:1623	Remarkably, this fragment can be attached to any xylose unit.
33139538	0	22	theme	capsid	101:106	arg1	glycans					125:131	its capsid protein N-linked glycans	97:131	its capsid protein N-linked glycans	97:131	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	7	23	theme	single	1449:1454	arg1	A064R					1464:1468	a single protein A064R	1447:1468	a single protein A064R	1447:1468	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	2	24	theme	glycans	402:408	arg1	synthesis					385:393	the synthesis	381:393	the synthesis of the glycans attached to its major capsid protein	381:445	Unlike many other viruses, PBCV-1 encodes most, if not all, of the enzymes involved in the synthesis of the glycans attached to its major capsid protein.
33139538	3	25	from	sequon	586:591	arg1	life					528:531	life	528:531	life in terms of structure and asparagine location in the sequon of the protein	528:606	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	3	25	from	sequon	586:591	arg1	domains					517:523	the three domains	507:523	the three domains of life in terms of structure and asparagine location in the sequon of the protein	507:606	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	0	26	theme	PBCV-1	12:17	arg1	A064R					27:31	Chlorovirus PBCV-1 protein A064R	0:31	Chlorovirus PBCV-1 protein A064R	0:31	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	2	27	theme	capsid	432:437	arg1	protein					439:445	its major capsid protein	422:445	its major capsid protein	422:445	Unlike many other viruses, PBCV-1 encodes most, if not all, of the enzymes involved in the synthesis of the glycans attached to its major capsid protein.
33139538	2	28	theme	other	306:310	arg1	viruses					312:318	many other viruses	301:318	many other viruses	301:318	Unlike many other viruses, PBCV-1 encodes most, if not all, of the enzymes involved in the synthesis of the glycans attached to its major capsid protein.
33139538	0	29	link	N-linked	116:123	arg1	glycans					125:131	its capsid protein N-linked glycans	97:131	its capsid protein N-linked glycans	97:131	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	4	30	theme	Previous	609:616	arg1	data					618:621	Previous data	609:621	Previous data collected from 20 PBCV-1 spontaneous mutants (or antigenic variants)	609:690	Previous data collected from 20 PBCV-1 spontaneous mutants (or antigenic variants) suggested that the a064r gene encodes a glycosyltransferase (GT) with three domains, each with a different function.
33139538	0	31	theme	Chlorovirus	0:10	arg1	A064R					27:31	Chlorovirus PBCV-1 protein A064R	0:31	Chlorovirus PBCV-1 protein A064R	0:31	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	6	32	theme	group	1143:1147	arg1	methylation					1111:1121	methylation	1111:1121	methylation of the C-3 hydroxyl group of the terminal α-l-Rha	1111:1171	We also establish that methylation of the C-3 hydroxyl group of the terminal α-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methylated substrate.
33139538	2	33	theme	many	301:304	arg1	viruses					312:318	many other viruses	301:318	many other viruses	301:318	Unlike many other viruses, PBCV-1 encodes most, if not all, of the enzymes involved in the synthesis of the glycans attached to its major capsid protein.
33139538	3	34	from	life	528:531	arg1	terms					536:540	terms	536:540	terms of structure and asparagine location	536:577	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	3	34	from	life	528:531	arg1	sequon					586:591	the sequon	582:591	the sequon of the protein	582:606	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	7	35	from	synthesis	1356:1364	arg1	PBCV-1					1419:1424	PBCV-1	1419:1424	PBCV-1	1419:1424	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	1	36	theme	Chlorella	266:274	arg1	NC64A					287:291	Chlorella variabilis NC64A	266:291	the unicellular green alga Chlorella variabilis NC64A	239:291	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	6	37	theme	hydroxyl	1134:1141	arg1	group					1143:1147	the C-3 hydroxyl group	1126:1147	the C-3 hydroxyl group of the terminal α-l-Rha	1126:1171	We also establish that methylation of the C-3 hydroxyl group of the terminal α-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methylated substrate.
33139538	6	37	theme	hydroxyl	1134:1141	arg1	α-l-Rha					1165:1171	the terminal α-l-Rha	1152:1171	the terminal α-l-Rha	1152:1171	We also establish that methylation of the C-3 hydroxyl group of the terminal α-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methylated substrate.
33139538	1	38	theme	large	186:190	arg1	virus					220:224	a large double-stranded DNA (dsDNA) virus	184:224	a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A	184:291	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	1	38	theme	large	186:190	arg1	virus-1					164:170	Paramecium bursaria chlorella virus-1	134:170	Paramecium bursaria chlorella virus-1 (PBCV-1)	134:179	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	0	39	theme	protein	19:25	arg1	A064R					27:31	Chlorovirus PBCV-1 protein A064R	0:31	Chlorovirus PBCV-1 protein A064R	0:31	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	1	40	theme	variabilis	276:285	arg1	NC64A					287:291	Chlorella variabilis NC64A	266:291	the unicellular green alga Chlorella variabilis NC64A	239:291	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	0	41	theme	N-linked	116:123	arg1	glycans					125:131	its capsid protein N-linked glycans	97:131	its capsid protein N-linked glycans	97:131	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	7	42	theme	-β-l-Rha	1545:1552	arg1	fragment					1554:1561	the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment	1522:1561	the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment	1522:1561	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	3	43	from	terms	536:540	arg1	life					528:531	life	528:531	life in terms of structure and asparagine location in the sequon of the protein	528:606	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	3	43	from	terms	536:540	arg1	domains					517:523	the three domains	507:523	the three domains of life in terms of structure and asparagine location in the sequon of the protein	507:606	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	1	44	theme	double-stranded	192:206	arg1	dsDNA					213:217	dsDNA	213:217	dsDNA	213:217	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	1	44	theme	double-stranded	192:206	arg1	DNA					208:210	double-stranded DNA	192:210	a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A	184:291	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	2	45	theme	major	426:430	arg1	protein					439:445	its major capsid protein	422:445	its major capsid protein	422:445	Unlike many other viruses, PBCV-1 encodes most, if not all, of the enzymes involved in the synthesis of the glycans attached to its major capsid protein.
33139538	5	46	theme	bacterial	932:940	arg1	proteins					942:949	only bacterial proteins	927:949	only bacterial proteins of unknown function	927:969	Here, we demonstrate that: domain 1 is a β-l-rhamnosyltransferase; domain 2 is an α-l-rhamnosyltransferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit.
33139538	7	47	theme	protein	1408:1414	arg1	N-glycan					1373:1380	the N-glycan	1369:1380	the N-glycan of the viral major capsid protein in PBCV-1	1369:1424	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	1	48	theme	DNA	208:210	arg1	virus					220:224	a large double-stranded DNA (dsDNA) virus	184:224	a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A	184:291	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	1	48	theme	DNA	208:210	arg1	virus-1					164:170	Paramecium bursaria chlorella virus-1	134:170	Paramecium bursaria chlorella virus-1 (PBCV-1)	134:179	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	7	49	from	N-glycan	1373:1380	arg1	PBCV-1					1419:1424	PBCV-1	1419:1424	PBCV-1	1419:1424	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	5	50	theme	terminal	1054:1061	arg1	unit					1082:1085	the terminal α-l-rhamnose (Rha) unit	1050:1085	the terminal α-l-rhamnose (Rha) unit	1050:1085	Here, we demonstrate that: domain 1 is a β-l-rhamnosyltransferase; domain 2 is an α-l-rhamnosyltransferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit.
33139538	6	51	theme	C-3	1130:1132	arg1	group					1143:1147	the C-3 hydroxyl group	1126:1147	the C-3 hydroxyl group of the terminal α-l-Rha	1126:1171	We also establish that methylation of the C-3 hydroxyl group of the terminal α-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methylated substrate.
33139538	6	51	theme	C-3	1130:1132	arg1	α-l-Rha					1165:1171	the terminal α-l-Rha	1152:1171	the terminal α-l-Rha	1152:1171	We also establish that methylation of the C-3 hydroxyl group of the terminal α-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methylated substrate.
33139538	5	52	theme	α-l-rhamnose	1063:1074	arg1	unit					1082:1085	the terminal α-l-rhamnose (Rha) unit	1050:1085	the terminal α-l-rhamnose (Rha) unit	1050:1085	Here, we demonstrate that: domain 1 is a β-l-rhamnosyltransferase; domain 2 is an α-l-rhamnosyltransferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit.
33139538	5	53	theme	unit	1082:1085	arg1	group					1041:1045	the C-2 hydroxyl group	1024:1045	the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit	1024:1085	Here, we demonstrate that: domain 1 is a β-l-rhamnosyltransferase; domain 2 is an α-l-rhamnosyltransferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit.
33139538	5	53	theme	unit	1082:1085	arg1	unit					1082:1085	the terminal α-l-rhamnose (Rha) unit	1050:1085	the terminal α-l-rhamnose (Rha) unit	1050:1085	Here, we demonstrate that: domain 1 is a β-l-rhamnosyltransferase; domain 2 is an α-l-rhamnosyltransferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit.
33139538	3	54	theme	life	528:531	arg1	life					528:531	life	528:531	life in terms of structure and asparagine location in the sequon of the protein	528:606	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	3	54	theme	life	528:531	arg1	domains					517:523	the three domains	507:523	the three domains of life in terms of structure and asparagine location in the sequon of the protein	507:606	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	4	55	theme	spontaneous	648:658	arg1	variants					682:689	antigenic variants	672:689	antigenic variants	672:689	Previous data collected from 20 PBCV-1 spontaneous mutants (or antigenic variants) suggested that the a064r gene encodes a glycosyltransferase (GT) with three domains, each with a different function.
33139538	4	55	theme	spontaneous	648:658	arg1	mutants					660:666	20 PBCV-1 spontaneous mutants	638:666	20 PBCV-1 spontaneous mutants (or antigenic variants)	638:690	Previous data collected from 20 PBCV-1 spontaneous mutants (or antigenic variants) suggested that the a064r gene encodes a glycosyltransferase (GT) with three domains, each with a different function.
33139538	6	56	theme	protein	1210:1216	arg1	A061L					1218:1222	another virus-encoded protein A061L	1188:1222	another virus-encoded protein A061L	1188:1222	We also establish that methylation of the C-3 hydroxyl group of the terminal α-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methylated substrate.
33139538	5	57	theme	function	962:969	arg1	proteins					942:949	only bacterial proteins	927:949	only bacterial proteins of unknown function	927:969	Here, we demonstrate that: domain 1 is a β-l-rhamnosyltransferase; domain 2 is an α-l-rhamnosyltransferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit.
33139538	5	58	theme	unknown	954:960	arg1	function					962:969	unknown function	954:969	unknown function	954:969	Here, we demonstrate that: domain 1 is a β-l-rhamnosyltransferase; domain 2 is an α-l-rhamnosyltransferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit.
33139538	4	59	theme	PBCV-1	641:646	arg1	variants					682:689	antigenic variants	672:689	antigenic variants	672:689	Previous data collected from 20 PBCV-1 spontaneous mutants (or antigenic variants) suggested that the a064r gene encodes a glycosyltransferase (GT) with three domains, each with a different function.
33139538	4	59	theme	PBCV-1	641:646	arg1	mutants					660:666	20 PBCV-1 spontaneous mutants	638:666	20 PBCV-1 spontaneous mutants (or antigenic variants)	638:690	Previous data collected from 20 PBCV-1 spontaneous mutants (or antigenic variants) suggested that the a064r gene encodes a glycosyltransferase (GT) with three domains, each with a different function.
33139538	5	60	theme	Rha	1077:1079	arg1	unit					1082:1085	the terminal α-l-rhamnose (Rha) unit	1050:1085	the terminal α-l-rhamnose (Rha) unit	1050:1085	Here, we demonstrate that: domain 1 is a β-l-rhamnosyltransferase; domain 2 is an α-l-rhamnosyltransferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit.
33139538	6	61	theme	virus-encoded	1196:1208	arg1	A061L					1218:1222	another virus-encoded protein A061L	1188:1222	another virus-encoded protein A061L	1188:1222	We also establish that methylation of the C-3 hydroxyl group of the terminal α-l-Rha is achieved by another virus-encoded protein A061L, which requires an O-2 methylated substrate.
33139538	7	62	contain	possesses	1470:1478	arg2	activities					1490:1499	the three activities	1480:1499	the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment	1480:1561	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	7	62	contain	possesses	1470:1478	arg1	A064R					1464:1468	a single protein A064R	1447:1468	a single protein A064R	1447:1468	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	3	63	theme	asparagine	559:568	arg1	location					570:577	asparagine location	559:577	asparagine location	559:577	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	7	64	theme	capsid	1401:1406	arg1	protein					1408:1414	the viral major capsid protein	1385:1414	the viral major capsid protein	1385:1414	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	4	65	theme	a064r	711:715	arg1	gene					717:720	the a064r gene	707:720	the a064r gene	707:720	Previous data collected from 20 PBCV-1 spontaneous mutants (or antigenic variants) suggested that the a064r gene encodes a glycosyltransferase (GT) with three domains, each with a different function.
33139538	4	65	theme	a064r	711:715	arg1	glycosyltransferase					732:750	a glycosyltransferase	730:750	a glycosyltransferase (GT) with three domains, each with a different function	730:806	Previous data collected from 20 PBCV-1 spontaneous mutants (or antigenic variants) suggested that the a064r gene encodes a glycosyltransferase (GT) with three domains, each with a different function.
33139538	7	66	theme	viral	1389:1393	arg1	protein					1408:1414	the viral major capsid protein	1385:1414	the viral major capsid protein	1385:1414	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	3	67	theme	location	570:577	arg1	terms					536:540	terms	536:540	terms of structure and asparagine location	536:577	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	1	68	theme	Paramecium	134:143	arg1	virus					220:224	a large double-stranded DNA (dsDNA) virus	184:224	a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A	184:291	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	1	68	theme	Paramecium	134:143	arg1	PBCV-1					173:178	PBCV-1	173:178	PBCV-1	173:178	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	1	68	theme	Paramecium	134:143	arg1	virus-1					164:170	Paramecium bursaria chlorella virus-1	134:170	Paramecium bursaria chlorella virus-1 (PBCV-1)	134:179	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	3	69	from	domains	517:523	arg1	terms					536:540	terms	536:540	terms of structure and asparagine location	536:577	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	3	69	from	domains	517:523	arg1	sequon					586:591	the sequon	582:591	the sequon of the protein	582:606	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	0	70	theme	activities	62:71	arg1	three					37:41	three	37:41	three	37:41	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	0	70	theme	activities	62:71	arg1	activities					62:71	the transferase activities	46:71	the transferase activities necessary to synthesize its capsid protein N-linked glycans	46:131	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	3	71	theme	protein	600:606	arg1	sequon					586:591	the sequon	582:591	the sequon of the protein	582:606	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	3	72	theme	structure	545:553	arg1	terms					536:540	terms	536:540	terms of structure and asparagine location	536:577	Importantly, these glycans differ from those reported from the three domains of life in terms of structure and asparagine location in the sequon of the protein.
33139538	1	73	theme	bursaria	145:152	arg1	virus					220:224	a large double-stranded DNA (dsDNA) virus	184:224	a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A	184:291	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	1	73	theme	bursaria	145:152	arg1	PBCV-1					173:178	PBCV-1	173:178	PBCV-1	173:178	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	1	73	theme	bursaria	145:152	arg1	virus-1					164:170	Paramecium bursaria chlorella virus-1	134:170	Paramecium bursaria chlorella virus-1 (PBCV-1)	134:179	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	0	74	theme	transferase	50:60	arg1	activities					62:71	the transferase activities	46:71	the transferase activities necessary to synthesize its capsid protein N-linked glycans	46:131	Chlorovirus PBCV-1 protein A064R has three of the transferase activities necessary to synthesize its capsid protein N-linked glycans.
33139538	5	75	theme	hydroxyl	1032:1039	arg1	group					1041:1045	the C-2 hydroxyl group	1024:1045	the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit	1024:1085	Here, we demonstrate that: domain 1 is a β-l-rhamnosyltransferase; domain 2 is an α-l-rhamnosyltransferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit.
33139538	5	75	theme	hydroxyl	1032:1039	arg1	unit					1082:1085	the terminal α-l-rhamnose (Rha) unit	1050:1085	the terminal α-l-rhamnose (Rha) unit	1050:1085	Here, we demonstrate that: domain 1 is a β-l-rhamnosyltransferase; domain 2 is an α-l-rhamnosyltransferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit.
33139538	5	76	theme	only	927:930	arg1	proteins					942:949	only bacterial proteins	927:949	only bacterial proteins of unknown function	927:969	Here, we demonstrate that: domain 1 is a β-l-rhamnosyltransferase; domain 2 is an α-l-rhamnosyltransferase resembling only bacterial proteins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal α-l-rhamnose (Rha) unit.
33139538	7	77	from	PBCV-1	1419:1424	arg1	synthesis					1356:1364	the synthesis	1352:1364	the synthesis of the N-glycan of the viral major capsid protein in PBCV-1	1352:1424	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33139538	1	78	theme	chlorella	154:162	arg1	virus					220:224	a large double-stranded DNA (dsDNA) virus	184:224	a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A	184:291	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	1	78	theme	chlorella	154:162	arg1	PBCV-1					173:178	PBCV-1	173:178	PBCV-1	173:178	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	1	78	theme	chlorella	154:162	arg1	virus-1					164:170	Paramecium bursaria chlorella virus-1	134:170	Paramecium bursaria chlorella virus-1 (PBCV-1)	134:179	Paramecium bursaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chlorella variabilis NC64A.
33139538	7	79	theme	major	1395:1399	arg1	protein					1408:1414	the viral major capsid protein	1385:1414	the viral major capsid protein	1385:1414	This study, thus, identifies two of the glycosyltransferase activities involved in the synthesis of the N-glycan of the viral major capsid protein in PBCV-1 and establishes that a single protein A064R possesses the three activities needed to synthetize the 2-OMe-α-l-Rha-(1→2)-β-l-Rha fragment.
33595259	5	0	theme	brain	831:835	arg1	dysfunction					837:847	brain dysfunction	831:847	brain dysfunction in septic rats	831:862	More interestingly, fecal microbiota transplantation exerted the best protective effects in brain dysfunction in septic rats.
33595259	1	1	theme	microbiota	177:186	arg1	dysbiosis					188:196	gut microbiota dysbiosis	173:196	gut microbiota dysbiosis	173:196	OBJECTIVE To compare the efficacy of four therapeutic methods to modify gut microbiota dysbiosis and brain dysfunction in septic rats.
33595259	4	2	theme	intestinal	618:627	arg1	diversity					639:647	intestinal microbial diversity	618:647	intestinal microbial diversity	618:647	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	6	3	from	function	1027:1034	arg1	rats					1046:1049	septic rats	1039:1049	septic rats	1039:1049	CONCLUSION Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats.
33595259	4	4	theme	Fecal	542:546	arg1	method					600:605	the most efficacious method	579:605	the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects	579:685	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	4	4	theme	Fecal	542:546	arg1	transplantation					559:573	Fecal microbiota transplantation	542:573	Fecal microbiota transplantation	542:573	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	1	5	from	dysbiosis	188:196	arg1	rats					230:233	septic rats	223:233	septic rats	223:233	OBJECTIVE To compare the efficacy of four therapeutic methods to modify gut microbiota dysbiosis and brain dysfunction in septic rats.
33595259	4	6	theme	microbial	629:637	arg1	diversity					639:647	intestinal microbial diversity	618:647	intestinal microbial diversity	618:647	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	5	7	theme	best	804:807	arg1	effects					820:826	the best protective effects	800:826	the best protective effects	800:826	More interestingly, fecal microbiota transplantation exerted the best protective effects in brain dysfunction in septic rats.
33595259	7	8	theme	brain	1179:1183	arg1	function					1185:1192	brain function	1179:1192	brain function in sepsis	1179:1202	These findings reveal the protective consequence of microbiota modification, and the findings suggest opportunities to improve brain function in sepsis.
33595259	4	9	theme	corrective	668:677	arg1	effects					679:685	the best corrective effects	659:685	the best corrective effects	659:685	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	4	10	theme	septic	726:731	arg1	rats					733:736	septic rats	726:736	septic rats	726:736	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	3	11	theme	TNF-α	482:486	arg1	concentrations					464:477	the concentrations	460:477	the concentrations of TNF-α, IL-1β, and IL-6	460:503	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	3	11	theme	TNF-α	482:486	arg1	microbiota					415:424	gut microbiota	411:424	gut microbiota	411:424	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	3	11	theme	TNF-α	482:486	arg1	values					448:453	electroencephalogram values	427:453	electroencephalogram values	427:453	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	5	12	theme	protective	809:818	arg1	effects					820:826	the best protective effects	800:826	the best protective effects	800:826	More interestingly, fecal microbiota transplantation exerted the best protective effects in brain dysfunction in septic rats.
33595259	0	13	from	Modification	39:50	arg1	Encephalopathy					85:98	Lipopolysaccharide-Associated Encephalopathy	55:98	Lipopolysaccharide-Associated Encephalopathy	55:98	Therapeutic Methods for Gut Microbiota Modification in Lipopolysaccharide-Associated Encephalopathy.
33595259	0	14	theme	Therapeutic	0:10	arg1	Methods					12:18	Therapeutic Methods	0:18	Therapeutic Methods for Gut Microbiota Modification in Lipopolysaccharide-Associated Encephalopathy.	0:99	Therapeutic Methods for Gut Microbiota Modification in Lipopolysaccharide-Associated Encephalopathy.
33595259	4	15	from	composition	711:721	arg1	rats					733:736	septic rats	726:736	septic rats	726:736	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	1	16	theme	brain	202:206	arg1	dysfunction					208:218	brain dysfunction	202:218	brain dysfunction	202:218	OBJECTIVE To compare the efficacy of four therapeutic methods to modify gut microbiota dysbiosis and brain dysfunction in septic rats.
33595259	6	17	theme	useful	946:951	arg1	method					953:958	the most useful method	937:958	the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats	937:1049	CONCLUSION Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats.
33595259	6	17	theme	useful	946:951	arg1	transplantation					917:931	fecal microbiota transplantation	900:931	fecal microbiota transplantation	900:931	CONCLUSION Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats.
33595259	3	18	theme	concentrations	464:477	arg1	composition					396:406	composition	396:406	composition	396:406	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	3	18	theme	concentrations	464:477	arg1	diversity					382:390	diversity	382:390	diversity	382:390	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	3	19	theme	electroencephalogram	427:446	arg1	values					448:453	electroencephalogram values	427:453	electroencephalogram values	427:453	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	4	20	theme	efficacious	588:598	arg1	method					600:605	the most efficacious method	579:605	the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects	579:685	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	4	20	theme	efficacious	588:598	arg1	transplantation					559:573	Fecal microbiota transplantation	542:573	Fecal microbiota transplantation	542:573	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	6	21	theme	microbiota	906:915	arg1	method					953:958	the most useful method	937:958	the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats	937:1049	CONCLUSION Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats.
33595259	6	21	theme	microbiota	906:915	arg1	transplantation					917:931	fecal microbiota transplantation	900:931	fecal microbiota transplantation	900:931	CONCLUSION Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats.
33595259	3	22	theme	gut	411:413	arg1	microbiota					415:424	gut microbiota	411:424	gut microbiota	411:424	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	6	23	theme	septic	1039:1044	arg1	rats					1046:1049	septic rats	1039:1049	septic rats	1039:1049	CONCLUSION Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats.
33595259	6	24	dep	CONCLUSION	865:874	arg1	methods					891:897	the four methods	882:897	the four methods	882:897	CONCLUSION Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats.
33595259	1	25	theme	septic	223:228	arg1	rats					230:233	septic rats	223:233	septic rats	223:233	OBJECTIVE To compare the efficacy of four therapeutic methods to modify gut microbiota dysbiosis and brain dysfunction in septic rats.
33595259	3	26	theme	microbiota	415:424	arg1	composition					396:406	composition	396:406	composition	396:406	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	3	26	theme	microbiota	415:424	arg1	diversity					382:390	diversity	382:390	diversity	382:390	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	5	27	theme	fecal	759:763	arg1	transplantation					776:790	fecal microbiota transplantation	759:790	fecal microbiota transplantation	759:790	More interestingly, fecal microbiota transplantation exerted the best protective effects in brain dysfunction in septic rats.
33595259	3	28	from	diversity	382:390	arg1	cortex					512:517	the cortex	508:517	the cortex	508:517	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	3	29	theme	IL-6	500:503	arg1	concentrations					464:477	the concentrations	460:477	the concentrations of TNF-α, IL-1β, and IL-6	460:503	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	3	29	theme	IL-6	500:503	arg1	microbiota					415:424	gut microbiota	411:424	gut microbiota	411:424	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	3	29	theme	IL-6	500:503	arg1	values					448:453	electroencephalogram values	427:453	electroencephalogram values	427:453	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	7	30	from	function	1185:1192	arg1	sepsis					1197:1202	sepsis	1197:1202	sepsis	1197:1202	These findings reveal the protective consequence of microbiota modification, and the findings suggest opportunities to improve brain function in sepsis.
33595259	5	31	theme	microbiota	765:774	arg1	transplantation					776:790	fecal microbiota transplantation	759:790	fecal microbiota transplantation	759:790	More interestingly, fecal microbiota transplantation exerted the best protective effects in brain dysfunction in septic rats.
33595259	3	32	theme	IL-1β	489:493	arg1	concentrations					464:477	the concentrations	460:477	the concentrations of TNF-α, IL-1β, and IL-6	460:503	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	3	32	theme	IL-1β	489:493	arg1	microbiota					415:424	gut microbiota	411:424	gut microbiota	411:424	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	3	32	theme	IL-1β	489:493	arg1	values					448:453	electroencephalogram values	427:453	electroencephalogram values	427:453	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	0	33	theme	Microbiota	28:37	arg1	Modification					39:50	Gut Microbiota Modification	24:50	Gut Microbiota Modification in Lipopolysaccharide-Associated Encephalopathy	24:98	Therapeutic Methods for Gut Microbiota Modification in Lipopolysaccharide-Associated Encephalopathy.
33595259	6	34	theme	brain	1021:1025	arg1	function					1027:1034	brain function	1021:1034	brain function in septic rats	1021:1049	CONCLUSION Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats.
33595259	5	35	theme	septic	852:857	arg1	rats					859:862	septic rats	852:862	septic rats	852:862	More interestingly, fecal microbiota transplantation exerted the best protective effects in brain dysfunction in septic rats.
33595259	3	36	from	composition	396:406	arg1	cortex					512:517	the cortex	508:517	the cortex	508:517	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	0	37	theme	Gut	24:26	arg1	Modification					39:50	Gut Microbiota Modification	24:50	Gut Microbiota Modification in Lipopolysaccharide-Associated Encephalopathy	24:98	Therapeutic Methods for Gut Microbiota Modification in Lipopolysaccharide-Associated Encephalopathy.
33595259	3	38	theme	values	448:453	arg1	composition					396:406	composition	396:406	composition	396:406	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	3	38	theme	values	448:453	arg1	diversity					382:390	diversity	382:390	diversity	382:390	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	4	39	theme	microbiota	548:557	arg1	method					600:605	the most efficacious method	579:605	the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects	579:685	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	4	39	theme	microbiota	548:557	arg1	transplantation					559:573	Fecal microbiota transplantation	542:573	Fecal microbiota transplantation	542:573	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	3	40	dep	diversity	382:390	arg1	The					378:380	The	378:380	The	378:380	The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed.
33595259	2	41	theme	METHODS	236:242	arg1	Rats					244:247	METHODS Rats	236:247	METHODS Rats	236:247	METHODS Rats were treated with fecal microbiota transplantation, prebiotics, probiotics, and synbiotics after exposure to lipopolysaccharide.
33595259	6	42	theme	fecal	900:904	arg1	method					953:958	the most useful method	937:958	the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats	937:1049	CONCLUSION Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats.
33595259	6	42	theme	fecal	900:904	arg1	transplantation					917:931	fecal microbiota transplantation	900:931	fecal microbiota transplantation	900:931	CONCLUSION Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats.
33595259	1	43	theme	therapeutic	143:153	arg1	methods					155:161	four therapeutic methods	138:161	four therapeutic methods	138:161	OBJECTIVE To compare the efficacy of four therapeutic methods to modify gut microbiota dysbiosis and brain dysfunction in septic rats.
33595259	6	44	theme	microbiota	998:1007	arg1	dysbiosis					974:982	the dysbiosis	970:982	the dysbiosis of intestinal microbiota	970:1007	CONCLUSION Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats.
33595259	7	45	theme	microbiota	1104:1113	arg1	modification					1115:1126	microbiota modification	1104:1126	microbiota modification	1104:1126	These findings reveal the protective consequence of microbiota modification, and the findings suggest opportunities to improve brain function in sepsis.
33595259	5	46	from	dysfunction	837:847	arg1	rats					859:862	septic rats	852:862	septic rats	852:862	More interestingly, fecal microbiota transplantation exerted the best protective effects in brain dysfunction in septic rats.
33595259	7	47	theme	protective	1078:1087	arg1	consequence					1089:1099	the protective consequence	1074:1099	the protective consequence of microbiota modification	1074:1126	These findings reveal the protective consequence of microbiota modification, and the findings suggest opportunities to improve brain function in sepsis.
33595259	1	48	theme	methods	155:161	arg1	efficacy					126:133	the efficacy	122:133	the efficacy of four therapeutic methods to modify gut microbiota dysbiosis and brain dysfunction in septic rats	122:233	OBJECTIVE To compare the efficacy of four therapeutic methods to modify gut microbiota dysbiosis and brain dysfunction in septic rats.
33595259	7	49	theme	modification	1115:1126	arg1	consequence					1089:1099	the protective consequence	1074:1099	the protective consequence of microbiota modification	1074:1126	These findings reveal the protective consequence of microbiota modification, and the findings suggest opportunities to improve brain function in sepsis.
33595259	1	50	from	dysfunction	208:218	arg1	rats					230:233	septic rats	223:233	septic rats	223:233	OBJECTIVE To compare the efficacy of four therapeutic methods to modify gut microbiota dysbiosis and brain dysfunction in septic rats.
33595259	2	51	theme	microbiota	273:282	arg1	transplantation					284:298	fecal microbiota transplantation	267:298	fecal microbiota transplantation	267:298	METHODS Rats were treated with fecal microbiota transplantation, prebiotics, probiotics, and synbiotics after exposure to lipopolysaccharide.
33595259	4	52	theme	microbial	701:709	arg1	composition					711:721	microbial composition	701:721	microbial composition in septic rats	701:736	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	4	53	theme	best	663:666	arg1	effects					679:685	the best corrective effects	659:685	the best corrective effects	659:685	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	0	54	theme	Lipopolysaccharide-Associated	55:83	arg1	Encephalopathy					85:98	Lipopolysaccharide-Associated Encephalopathy	55:98	Lipopolysaccharide-Associated Encephalopathy	55:98	Therapeutic Methods for Gut Microbiota Modification in Lipopolysaccharide-Associated Encephalopathy.
33595259	6	55	theme	intestinal	987:996	arg1	microbiota					998:1007	intestinal microbiota	987:1007	intestinal microbiota	987:1007	CONCLUSION Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats.
33595259	2	56	theme	fecal	267:271	arg1	transplantation					284:298	fecal microbiota transplantation	267:298	fecal microbiota transplantation	267:298	METHODS Rats were treated with fecal microbiota transplantation, prebiotics, probiotics, and synbiotics after exposure to lipopolysaccharide.
33595259	1	57	theme	gut	173:175	arg1	dysbiosis					188:196	gut microbiota dysbiosis	173:196	gut microbiota dysbiosis	173:196	OBJECTIVE To compare the efficacy of four therapeutic methods to modify gut microbiota dysbiosis and brain dysfunction in septic rats.
33595259	4	58	dep	RESULTS	534:540	arg1	method					600:605	the most efficacious method	579:605	the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects	579:685	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
33595259	4	58	dep	RESULTS	534:540	arg1	transplantation					559:573	Fecal microbiota transplantation	542:573	Fecal microbiota transplantation	542:573	RESULTS Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats.
34695298	7	0	theme	pronounced	1497:1506	arg1	activity					1529:1536	a pronounced anti-phytopathogenic activity	1495:1536	a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp	1495:1605	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	2	1	used	used	312:315	arg2	anions					300:305	Sulphide anions	291:305	Sulphide anions	291:305	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	2	1	used	used	312:315	arg2	precursors					328:337	sulphur precursors	320:337	sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms	320:515	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	2	2	theme	powder	381:386	arg1	sulphur					388:394	the bulk powder sulphur	372:394	the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms	372:515	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	7	3	theme	sulphur	1434:1440	arg1	nanoparticles					1442:1454	the starch-capped sulphur nanoparticles	1416:1454	the starch-capped sulphur nanoparticles	1416:1454	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	6	4	theme	nanocomposite	1271:1283	arg1	activity					1238:1245	the anti-microbial activity	1219:1245	the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method	1219:1376	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	3	5	theme	microscopic	553:563	arg1	methods					565:571	modern spectral and microscopic methods	533:571	modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM)	533:609	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	4	6	theme	polysaccharide	864:877	arg1	matrix					886:891	the polysaccharide starch matrix	860:891	the polysaccharide starch matrix with a pronounced tendency to cluster into ring formations	860:950	It was found that nanocomposites are formed as sulphur particles with the shape which is nearly spherical dispersed in the polysaccharide starch matrix with a pronounced tendency to cluster into ring formations.
34695298	6	7	theme	In	1172:1173	arg1	experiments					1181:1191	In vitro experiments	1172:1191	In vitro experiments	1172:1191	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	6	8	dep	In	1172:1173	arg1	vitro					1175:1179	vitro	1175:1179	vitro	1175:1179	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	6	9	theme	obtained	1254:1261	arg1	nanocomposite					1271:1283	the obtained sulphur nanocomposite	1250:1283	the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method	1250:1376	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	6	9	theme	obtained	1254:1261	arg1	S					1291:1291	1.6% S	1286:1291	1.6% S	1286:1291	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	5	10	from	macromolecules	1047:1060	arg1	surface					1069:1075	the surface	1065:1075	the surface of sulphur nanoparticles	1065:1100	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	1	11	theme	9-52 nm	218:224	arg1	size					210:213	a size	208:213	a size of 9-52 nm	208:224	Water-soluble, stable nanoparticles of elemental sulphur with a size of 9-52 nm have been synthesised using the stabilising potential of starch.
34695298	6	12	dep	iodide	1314:1319	arg1	dye					1333:1335	fluorescent dye	1321:1335	the propidium iodide fluorescent dye staining method	1300:1351	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	4	13	theme	ring	936:939	arg1	formations					941:950	ring formations	936:950	ring formations	936:950	It was found that nanocomposites are formed as sulphur particles with the shape which is nearly spherical dispersed in the polysaccharide starch matrix with a pronounced tendency to cluster into ring formations.
34695298	6	14	theme	staining	1337:1344	arg1	method					1346:1351	the propidium iodide fluorescent dye staining method	1300:1351	the propidium iodide fluorescent dye staining method	1300:1351	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	5	15	theme	nanoparticles	1088:1100	arg1	surface					1069:1075	the surface	1065:1075	the surface of sulphur nanoparticles	1065:1100	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	6	16	theme	fluorescent	1321:1331	arg1	dye					1333:1335	fluorescent dye	1321:1335	the propidium iodide fluorescent dye staining method	1300:1351	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	2	17	with	oxidation	460:468	arg1	oxygen					485:490	molecular oxygen	475:490	molecular oxygen	475:490	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	6	18	theme	propidium	1304:1312	arg1	iodide					1314:1319	the propidium iodide	1300:1319	the propidium iodide fluorescent dye staining method	1300:1351	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	3	19	theme	phase	616:620	arg1	state					622:626	the phase state	612:626	the phase state	612:626	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	4	20	with	matrix	886:891	arg1	tendency					911:918	a pronounced tendency	898:918	a pronounced tendency to cluster into ring formations	898:950	It was found that nanocomposites are formed as sulphur particles with the shape which is nearly spherical dispersed in the polysaccharide starch matrix with a pronounced tendency to cluster into ring formations.
34695298	5	21	theme	obtained	991:998	arg1	nanoparticles					1000:1012	the obtained nanoparticles	987:1012	the obtained nanoparticles	987:1012	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	3	22	theme	methods	565:571	arg1	methods					565:571	modern spectral and microscopic methods	533:571	modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM)	533:609	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	3	22	theme	methods	565:571	arg1	set					526:528	a set	524:528	a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM)	524:609	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	5	23	theme	shell	1141:1145	arg1	thickness					1112:1120	the thickness	1108:1120	the thickness of the stabilising shell in a range of 10-171 nm	1108:1169	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	1	24	theme	elemental	185:193	arg1	sulphur					195:201	elemental sulphur	185:201	elemental sulphur	185:201	Water-soluble, stable nanoparticles of elemental sulphur with a size of 9-52 nm have been synthesised using the stabilising potential of starch.
34695298	0	25	theme	anti-phytopathogenic	83:102	arg1	activity					104:111	their anti-phytopathogenic activity	77:111	their anti-phytopathogenic activity against Clavibacter sepedonicus	77:143	Starch-capped sulphur nanoparticles synthesised from bulk powder sulphur and their anti-phytopathogenic activity against Clavibacter sepedonicus.
34695298	2	26	theme	Sulphide	291:298	arg1	precursors					328:337	sulphur precursors	320:337	sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms	320:515	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	2	26	theme	Sulphide	291:298	arg1	anions					300:305	Sulphide anions	291:305	Sulphide anions	291:305	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	6	27	theme	diffusion	1361:1369	arg1	method					1371:1376	the diffusion method	1357:1376	the diffusion method	1357:1376	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	7	28	theme	michiganensis	1587:1599	arg1	subsp					1601:1605	the potato ring rot pathogen Clavibacter michiganensis subsp	1546:1605	the potato ring rot pathogen Clavibacter michiganensis subsp	1546:1605	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	4	29	theme	sulphur	788:794	arg1	particles					796:804	sulphur particles	788:804	sulphur particles with the shape which is nearly spherical dispersed in the polysaccharide starch matrix with a pronounced tendency to cluster into ring formations	788:950	It was found that nanocomposites are formed as sulphur particles with the shape which is nearly spherical dispersed in the polysaccharide starch matrix with a pronounced tendency to cluster into ring formations.
34695298	4	29	theme	sulphur	788:794	arg1	nanocomposites					759:772	nanocomposites	759:772	nanocomposites	759:772	It was found that nanocomposites are formed as sulphur particles with the shape which is nearly spherical dispersed in the polysaccharide starch matrix with a pronounced tendency to cluster into ring formations.
34695298	2	30	theme	H4	433:434	arg1	O					440:440	the base-reduction system NaOH-N2 H4 ·H2 O	399:440	the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms	399:515	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	1	31	with	nanoparticles	168:180	arg1	size					210:213	a size	208:213	a size of 9-52 nm	208:224	Water-soluble, stable nanoparticles of elemental sulphur with a size of 9-52 nm have been synthesised using the stabilising potential of starch.
34695298	5	32	theme	nanoparticles	1000:1012	arg1	stability					974:982	stability	974:982	stability	974:982	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	5	32	theme	nanoparticles	1000:1012	arg1	solubility					959:968	Water solubility	953:968	Water solubility	953:968	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	2	33	theme	molecular	475:483	arg1	oxygen					485:490	molecular oxygen	475:490	molecular oxygen	475:490	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	2	34	theme	system	418:423	arg1	O					440:440	the base-reduction system NaOH-N2 H4 ·H2 O	399:440	the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms	399:515	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	0	35	theme	Starch-capped	0:12	arg1	nanoparticles					22:34	Starch-capped sulphur nanoparticles	0:34	Starch-capped sulphur nanoparticles	0:34	Starch-capped sulphur nanoparticles synthesised from bulk powder sulphur and their anti-phytopathogenic activity against Clavibacter sepedonicus.
34695298	7	36	theme	rot	1562:1564	arg1	subsp					1601:1605	the potato ring rot pathogen Clavibacter michiganensis subsp	1546:1605	the potato ring rot pathogen Clavibacter michiganensis subsp	1546:1605	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	2	37	theme	sulphur	503:509	arg1	atoms					511:515	element sulphur atoms	495:515	element sulphur atoms	495:515	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	5	38	from	range	1152:1156	arg1	thickness					1112:1120	the thickness	1108:1120	the thickness of the stabilising shell in a range of 10-171 nm	1108:1169	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	7	39	theme	potato	1550:1555	arg1	subsp					1601:1605	the potato ring rot pathogen Clavibacter michiganensis subsp	1546:1605	the potato ring rot pathogen Clavibacter michiganensis subsp	1546:1605	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	5	40	theme	starch	1040:1045	arg1	macromolecules					1047:1060	starch macromolecules	1040:1060	starch macromolecules on the surface of sulphur nanoparticles	1040:1100	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	2	41	theme	bulk	376:379	arg1	sulphur					388:394	the bulk powder sulphur	372:394	the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms	372:515	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	0	42	theme	powder	58:63	arg1	sulphur					65:71	bulk powder sulphur	53:71	bulk powder sulphur	53:71	Starch-capped sulphur nanoparticles synthesised from bulk powder sulphur and their anti-phytopathogenic activity against Clavibacter sepedonicus.
34695298	7	43	theme	anti-phytopathogenic	1508:1527	arg1	activity					1529:1536	a pronounced anti-phytopathogenic activity	1495:1536	a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp	1495:1605	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	3	44	theme	modern	533:538	arg1	methods					565:571	modern spectral and microscopic methods	533:571	modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM)	533:609	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	1	45	theme	starch	283:288	arg1	potential					270:278	the stabilising potential	254:278	the stabilising potential of starch	254:288	Water-soluble, stable nanoparticles of elemental sulphur with a size of 9-52 nm have been synthesised using the stabilising potential of starch.
34695298	7	46	theme	6.25 µg/ml	1480:1489	arg1	concentration					1463:1475	the concentration	1459:1475	the concentration of 6.25 µg/ml	1459:1489	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	4	47	theme	starch	879:884	arg1	matrix					886:891	the polysaccharide starch matrix	860:891	the polysaccharide starch matrix with a pronounced tendency to cluster into ring formations	860:950	It was found that nanocomposites are formed as sulphur particles with the shape which is nearly spherical dispersed in the polysaccharide starch matrix with a pronounced tendency to cluster into ring formations.
34695298	3	48	theme	nanomorphological	683:699	arg1	characteristics					701:715	their nanomorphological characteristics	677:715	their nanomorphological characteristics	677:715	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	6	49	theme	%	1289:1289	arg1	nanocomposite					1271:1283	the obtained sulphur nanocomposite	1250:1283	the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method	1250:1376	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	6	49	theme	%	1289:1289	arg1	S					1291:1291	1.6% S	1286:1291	1.6% S	1286:1291	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	2	50	theme	sulphur	320:326	arg1	precursors					328:337	sulphur precursors	320:337	sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms	320:515	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	2	50	theme	sulphur	320:326	arg1	anions					300:305	Sulphide anions	291:305	Sulphide anions	291:305	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	7	51	theme	nanoparticles	1442:1454	arg1	solution					1404:1411	the water solution	1394:1411	the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml	1394:1489	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	5	52	from	sorption	1028:1035	arg1	surface					1069:1075	the surface	1065:1075	the surface of sulphur nanoparticles	1065:1100	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	2	53	from	sulphur	388:394	arg1	O					440:440	the base-reduction system NaOH-N2 H4 ·H2 O	399:440	the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms	399:515	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	7	54	theme	starch-capped	1420:1432	arg1	nanoparticles					1442:1454	the starch-capped sulphur nanoparticles	1416:1454	the starch-capped sulphur nanoparticles	1416:1454	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	5	55	from	surface	1069:1075	arg1	sorption					1028:1035	sorption	1028:1035	sorption of starch macromolecules on the surface of sulphur nanoparticles	1028:1100	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	6	56	theme	sulphur	1263:1269	arg1	nanocomposite					1271:1283	the obtained sulphur nanocomposite	1250:1283	the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method	1250:1376	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	6	56	theme	sulphur	1263:1269	arg1	S					1291:1291	1.6% S	1286:1291	1.6% S	1286:1291	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	3	57	theme	optical	579:585	arg1	XRD					574:576	XRD	574:576	XRD	574:576	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	3	57	theme	optical	579:585	arg1	spectroscopy					587:598	optical spectroscopy	579:598	optical spectroscopy	579:598	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	7	58	theme	water	1398:1402	arg1	solution					1404:1411	the water solution	1394:1411	the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml	1394:1489	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	7	59	from	concentration	1463:1475	arg1	solution					1404:1411	the water solution	1394:1411	the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml	1394:1489	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	6	60	theme	iodide	1314:1319	arg1	method					1346:1351	the propidium iodide fluorescent dye staining method	1300:1351	the propidium iodide fluorescent dye staining method	1300:1351	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	1	61	theme	Water-soluble	146:158	arg1	nanoparticles					168:180	Water-soluble, stable nanoparticles	146:180	Water-soluble, stable nanoparticles of elemental sulphur with a size of 9-52 nm	146:224	Water-soluble, stable nanoparticles of elemental sulphur with a size of 9-52 nm have been synthesised using the stabilising potential of starch.
34695298	4	62	theme	pronounced	900:909	arg1	tendency					911:918	a pronounced tendency	898:918	a pronounced tendency to cluster into ring formations	898:950	It was found that nanocomposites are formed as sulphur particles with the shape which is nearly spherical dispersed in the polysaccharide starch matrix with a pronounced tendency to cluster into ring formations.
34695298	6	63	theme	anti-microbial	1223:1236	arg1	activity					1238:1245	the anti-microbial activity	1219:1245	the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method	1219:1376	In vitro experiments were carried out to study the anti-microbial activity of the obtained sulphur nanocomposite (1.6% S) using the propidium iodide fluorescent dye staining method and the diffusion method.
34695298	3	64	dep	methods	565:571	arg1	TEM					606:608	TEM	606:608	TEM	606:608	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	3	64	dep	methods	565:571	arg1	DLS					601:603	DLS	601:603	DLS	601:603	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	3	64	dep	methods	565:571	arg1	XRD					574:576	XRD	574:576	XRD	574:576	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	3	64	dep	methods	565:571	arg1	spectroscopy					587:598	optical spectroscopy	579:598	optical spectroscopy	579:598	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	5	65	theme	sulphur	1080:1086	arg1	nanoparticles					1088:1100	sulphur nanoparticles	1080:1100	sulphur nanoparticles	1080:1100	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	7	66	contain	had	1491:1493	arg1	solution					1404:1411	the water solution	1394:1411	the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml	1394:1489	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	7	66	contain	had	1491:1493	arg2	activity					1529:1536	a pronounced anti-phytopathogenic activity	1495:1536	a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp	1495:1605	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	1	67	theme	sulphur	195:201	arg1	nanoparticles					168:180	Water-soluble, stable nanoparticles	146:180	Water-soluble, stable nanoparticles of elemental sulphur with a size of 9-52 nm	146:224	Water-soluble, stable nanoparticles of elemental sulphur with a size of 9-52 nm have been synthesised using the stabilising potential of starch.
34695298	7	68	theme	Clavibacter	1575:1585	arg1	subsp					1601:1605	the potato ring rot pathogen Clavibacter michiganensis subsp	1546:1605	the potato ring rot pathogen Clavibacter michiganensis subsp	1546:1605	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	4	69	with	particles	796:804	arg1	shape					815:819	the shape	811:819	the shape which is nearly spherical dispersed in the polysaccharide starch matrix with a pronounced tendency to cluster into ring formations	811:950	It was found that nanocomposites are formed as sulphur particles with the shape which is nearly spherical dispersed in the polysaccharide starch matrix with a pronounced tendency to cluster into ring formations.
34695298	4	69	with	particles	796:804	arg1	spherical					837:845	spherical	837:845	spherical	837:845	It was found that nanocomposites are formed as sulphur particles with the shape which is nearly spherical dispersed in the polysaccharide starch matrix with a pronounced tendency to cluster into ring formations.
34695298	0	70	dep	Clavibacter	121:131	arg1	sepedonicus					133:143	Clavibacter sepedonicus	121:143	Clavibacter sepedonicus	121:143	Starch-capped sulphur nanoparticles synthesised from bulk powder sulphur and their anti-phytopathogenic activity against Clavibacter sepedonicus.
34695298	2	71	theme	NaOH-N2	425:431	arg1	O					440:440	the base-reduction system NaOH-N2 H4 ·H2 O	399:440	the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms	399:515	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	0	72	theme	sulphur	14:20	arg1	nanoparticles					22:34	Starch-capped sulphur nanoparticles	0:34	Starch-capped sulphur nanoparticles	0:34	Starch-capped sulphur nanoparticles synthesised from bulk powder sulphur and their anti-phytopathogenic activity against Clavibacter sepedonicus.
34695298	5	73	theme	stabilising	1129:1139	arg1	shell					1141:1145	the stabilising shell	1125:1145	the stabilising shell in a range of 10-171 nm	1125:1169	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	5	74	theme	Water	953:957	arg1	solubility					959:968	Water solubility	953:968	Water solubility	953:968	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	2	75	theme	base-reduction	403:416	arg1	O					440:440	the base-reduction system NaOH-N2 H4 ·H2 O	399:440	the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms	399:515	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	5	76	from	thickness	1112:1120	arg1	range					1152:1156	a range	1150:1156	a range of 10-171 nm	1150:1169	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	1	77	dep	Water-soluble	146:158	arg1	stable					161:166	stable	161:166	stable	161:166	Water-soluble, stable nanoparticles of elemental sulphur with a size of 9-52 nm have been synthesised using the stabilising potential of starch.
34695298	3	78	theme	elemental	629:637	arg1	composition					639:649	elemental composition	629:649	elemental composition of the nanocomposites	629:671	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	0	79	theme	bulk	53:56	arg1	sulphur					65:71	bulk powder sulphur	53:71	bulk powder sulphur	53:71	Starch-capped sulphur nanoparticles synthesised from bulk powder sulphur and their anti-phytopathogenic activity against Clavibacter sepedonicus.
34695298	7	80	theme	pathogen	1566:1573	arg1	subsp					1601:1605	the potato ring rot pathogen Clavibacter michiganensis subsp	1546:1605	the potato ring rot pathogen Clavibacter michiganensis subsp	1546:1605	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	2	81	theme	element	495:501	arg1	atoms					511:515	element sulphur atoms	495:515	element sulphur atoms	495:515	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	2	82	theme	·H2	436:438	arg1	O					440:440	the base-reduction system NaOH-N2 H4 ·H2 O	399:440	the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms	399:515	Sulphide anions were used as sulphur precursors that were generated earlier from the bulk powder sulphur in the base-reduction system NaOH-N2 H4 ·H2 O followed by their oxidation with molecular oxygen to element sulphur atoms.
34695298	5	83	from	shell	1141:1145	arg1	range					1152:1156	a range	1150:1156	a range of 10-171 nm	1150:1169	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	5	84	theme	10-171 nm	1161:1169	arg1	range					1152:1156	a range	1150:1156	a range of 10-171 nm	1150:1169	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	7	85	theme	ring	1557:1560	arg1	subsp					1601:1605	the potato ring rot pathogen Clavibacter michiganensis subsp	1546:1605	the potato ring rot pathogen Clavibacter michiganensis subsp	1546:1605	It showed that the water solution of the starch-capped sulphur nanoparticles at the concentration of 6.25 µg/ml had a pronounced anti-phytopathogenic activity against the potato ring rot pathogen Clavibacter michiganensis subsp.
34695298	5	86	theme	macromolecules	1047:1060	arg1	sorption					1028:1035	sorption	1028:1035	sorption of starch macromolecules on the surface of sulphur nanoparticles	1028:1100	Water solubility and stability of the obtained nanoparticles is ensured by sorption of starch macromolecules on the surface of sulphur nanoparticles, with the thickness of the stabilising shell in a range of 10-171 nm.
34695298	3	87	theme	nanocomposites	658:671	arg1	characteristics					701:715	their nanomorphological characteristics	677:715	their nanomorphological characteristics	677:715	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	3	87	theme	nanocomposites	658:671	arg1	state					622:626	the phase state	612:626	the phase state	612:626	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	3	87	theme	nanocomposites	658:671	arg1	composition					639:649	elemental composition	629:649	elemental composition of the nanocomposites	629:671	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
34695298	1	88	theme	stabilising	258:268	arg1	potential					270:278	the stabilising potential	254:278	the stabilising potential of starch	254:288	Water-soluble, stable nanoparticles of elemental sulphur with a size of 9-52 nm have been synthesised using the stabilising potential of starch.
34695298	3	89	theme	spectral	540:547	arg1	methods					565:571	modern spectral and microscopic methods	533:571	modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM)	533:609	Using a set of modern spectral and microscopic methods (XRD, optical spectroscopy, DLS, TEM), the phase state, elemental composition of the nanocomposites and their nanomorphological characteristics have been investigated.
32985066	0	0	theme	degradation	86:96	arg1	products					98:105	degradation products	86:105	degradation products	86:105	Immunological effects of Chondrus armatus carrageenans and their low molecular weight degradation products.
32985066	2	1	contain	had	694:696	arg2	effect					701:706	no effect	698:706	no effect	698:706	We demonstrated that, with an exception of one, all carrageenan samples at 100 μg/ml increased cellular motility and dose-dependently decreased phagocytic activity; LMWDPs of λ-carrageenan suppressed motility and had no effect on phagocytosis.
32985066	2	1	contain	had	694:696	arg1	LMWDPs					646:651	LMWDPs	646:651	LMWDPs of λ-carrageenan	646:668	We demonstrated that, with an exception of one, all carrageenan samples at 100 μg/ml increased cellular motility and dose-dependently decreased phagocytic activity; LMWDPs of λ-carrageenan suppressed motility and had no effect on phagocytosis.
32985066	6	2	theme	murine	1251:1256	arg1	macrophages					1269:1279	murine peritoneal macrophages	1251:1279	murine peritoneal macrophages phagocytic activity	1251:1299	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	6	3	theme	phagocytic	1281:1290	arg1	activity					1292:1299	murine peritoneal macrophages phagocytic activity	1251:1299	murine peritoneal macrophages phagocytic activity	1251:1299	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	3	4	from	100 μg/kg/day	779:791	arg1	administration					730:743	Oral administration	725:743	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice	725:810	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	1	5	theme	weight	234:239	arg1	experiment					469:478	a weeklong feeding experiment	450:478	a weeklong feeding experiment	450:478	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	5	theme	weight	234:239	arg1	Ability					108:114	Ability	108:114	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages	108:402	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	5	theme	weight	234:239	arg1	in					437:438	in	437:438	in	437:438	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	0	6	theme	weight	79:84	arg1	effects					14:20	Immunological effects	0:20	Immunological effects of Chondrus armatus carrageenans and their low molecular weight degradation products.	0:106	Immunological effects of Chondrus armatus carrageenans and their low molecular weight degradation products.
32985066	1	7	theme	functional	321:330	arg1	motility					344:351	motility	344:351	motility	344:351	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	7	theme	functional	321:330	arg1	properties					332:341	functional properties	321:341	functional properties (motility and phagocytosis) of murine peritoneal macrophages	321:402	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	7	theme	functional	321:330	arg1	phagocytosis					357:368	phagocytosis	357:368	phagocytosis	357:368	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	6	8	theme	in	1653:1654	arg1	conditions					1674:1683	both in vitro and in vivo conditions	1648:1683	both in vitro and in vivo conditions	1648:1683	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	1	9	dep	in	437:438	arg1	vitro					440:444	vitro	440:444	vitro	440:444	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	10	theme	degradation	241:251	arg1	products					253:260	degradation products	241:260	degradation products	241:260	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	11	dep	weight	134:139	arg1	10-170 kDa					283:292	10-170 kDa	283:292	10-170 kDa	283:292	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	11	dep	weight	134:139	arg1	0.7-20					272:277	0.7-20	272:277	0.7-20	272:277	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	11	dep	weight	134:139	arg1	products					253:260	degradation products	241:260	degradation products	241:260	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	3	12	theme	body	856:859	arg1	weight					861:866	body weight	856:866	body weight	856:866	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	5	13	theme	relative	1168:1175	arg1	count					1181:1185	relative WBC count	1168:1185	relative WBC count	1168:1185	Consumption of LMWDPs of κ-carrageenan resulted in development of leukopenia, however, no changes to relative WBC count were introduced by either of the samples.
32985066	6	14	dep	λ-counterparts	1479:1492	arg1	shown					1517:1521	shown	1517:1521	have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions	1512:1683	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	3	15	theme	noticeable	927:936	arg1	changes					938:944	noticeable changes	927:944	noticeable changes to their inner organs	927:966	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	2	16	theme	phagocytic	625:634	arg1	activity					636:643	phagocytic activity	625:643	phagocytic activity	625:643	We demonstrated that, with an exception of one, all carrageenan samples at 100 μg/ml increased cellular motility and dose-dependently decreased phagocytic activity; LMWDPs of λ-carrageenan suppressed motility and had no effect on phagocytosis.
32985066	5	17	theme	WBC	1177:1179	arg1	count					1181:1185	relative WBC count	1168:1185	relative WBC count	1168:1185	Consumption of LMWDPs of κ-carrageenan resulted in development of leukopenia, however, no changes to relative WBC count were introduced by either of the samples.
32985066	6	18	theme	higher	1328:1333	arg1	efficacy					1335:1342	higher efficacy	1328:1342	higher efficacy than their κ-counterparts	1328:1368	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	6	19	theme	macrophages	1630:1640	arg1	activity					1607:1614	phagocytotic activity	1594:1614	phagocytotic activity of peritoneal macrophages	1594:1640	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	3	20	theme	liver	885:889	arg1	weight					869:874	weight	869:874	weight of their liver, spleen or thymus	869:907	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	20	theme	liver	885:889	arg1	appearance					844:853	their clinical appearance	829:853	their clinical appearance	829:853	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	20	theme	liver	885:889	arg1	weight					861:866	body weight	856:866	body weight	856:866	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	20	theme	liver	885:889	arg1	development					912:922	development	912:922	development of noticeable changes to their inner organs	912:966	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	1	21	theme	λ-carrageenans	154:167	arg1	experiment					469:478	a weeklong feeding experiment	450:478	a weeklong feeding experiment	450:478	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	21	theme	λ-carrageenans	154:167	arg1	Ability					108:114	Ability	108:114	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages	108:402	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	21	theme	λ-carrageenans	154:167	arg1	in					437:438	in	437:438	in	437:438	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	6	22	contain	possessing	1317:1326	arg2	efficacy					1335:1342	higher efficacy	1328:1342	higher efficacy than their κ-counterparts	1328:1368	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	6	22	contain	possessing	1317:1326	arg1	λ-samples					1307:1315	λ-samples	1307:1315	λ-samples possessing higher efficacy than their κ-counterparts	1307:1368	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	7	23	theme	further	1788:1794	arg1	investigation					1796:1808	their further investigation	1782:1808	their further investigation	1782:1808	This allows them to be viewed as pharmacologically active substances andpropagates the need for their further investigation as such.
32985066	6	24	dep	armatus	1560:1566	arg1	the					1553:1555	the	1553:1555	the	1553:1555	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	6	25	dep	in	1666:1667	arg1	vivo					1669:1672	vivo	1669:1672	vivo	1669:1672	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	2	26	theme	λ-carrageenan	656:668	arg1	LMWDPs					646:651	LMWDPs	646:651	LMWDPs of λ-carrageenan	646:668	We demonstrated that, with an exception of one, all carrageenan samples at 100 μg/ml increased cellular motility and dose-dependently decreased phagocytic activity; LMWDPs of λ-carrageenan suppressed motility and had no effect on phagocytosis.
32985066	0	27	theme	Immunological	0:12	arg1	effects					14:20	Immunological effects	0:20	Immunological effects of Chondrus armatus carrageenans and their low molecular weight degradation products.	0:106	Immunological effects of Chondrus armatus carrageenans and their low molecular weight degradation products.
32985066	2	28	theme	cellular	576:583	arg1	motility					585:592	cellular motility	576:592	cellular motility	576:592	We demonstrated that, with an exception of one, all carrageenan samples at 100 μg/ml increased cellular motility and dose-dependently decreased phagocytic activity; LMWDPs of λ-carrageenan suppressed motility and had no effect on phagocytosis.
32985066	7	29	theme	active	1737:1742	arg1	them					1698:1701	them	1698:1701	them	1698:1701	This allows them to be viewed as pharmacologically active substances andpropagates the need for their further investigation as such.
32985066	7	29	theme	active	1737:1742	arg1	substances					1744:1753	pharmacologically active substances	1719:1753	pharmacologically active substances	1719:1753	This allows them to be viewed as pharmacologically active substances andpropagates the need for their further investigation as such.
32985066	5	30	theme	κ-carrageenan	1092:1104	arg1	LMWDPs					1082:1087	LMWDPs	1082:1087	LMWDPs of κ-carrageenan	1082:1104	Consumption of LMWDPs of κ-carrageenan resulted in development of leukopenia, however, no changes to relative WBC count were introduced by either of the samples.
32985066	1	31	theme	red	176:178	arg1	algae					187:191	the red marine algae	172:191	the red marine algae Chondrus armatus	172:208	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	0	32	theme	Chondrus	25:32	arg1	carrageenans					42:53	Chondrus armatus carrageenans	25:53	Chondrus armatus carrageenans	25:53	Immunological effects of Chondrus armatus carrageenans and their low molecular weight degradation products.
32985066	1	33	dep	properties	332:341	arg1	motility					344:351	motility	344:351	motility	344:351	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	33	dep	properties	332:341	arg1	properties					332:341	functional properties	321:341	functional properties (motility and phagocytosis) of murine peritoneal macrophages	321:402	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	33	dep	properties	332:341	arg1	phagocytosis					357:368	phagocytosis	357:368	phagocytosis	357:368	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	6	34	theme	phagocytotic	1594:1605	arg1	activity					1607:1614	phagocytotic activity	1594:1614	phagocytotic activity of peritoneal macrophages	1594:1640	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	3	35	theme	thymus	902:907	arg1	weight					869:874	weight	869:874	weight of their liver, spleen or thymus	869:907	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	35	theme	thymus	902:907	arg1	appearance					844:853	their clinical appearance	829:853	their clinical appearance	829:853	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	35	theme	thymus	902:907	arg1	weight					861:866	body weight	856:866	body weight	856:866	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	35	theme	thymus	902:907	arg1	development					912:922	development	912:922	development of noticeable changes to their inner organs	912:966	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	1	36	theme	marine	180:185	arg1	algae					187:191	the red marine algae	172:191	the red marine algae Chondrus armatus	172:208	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	3	37	theme	Oral	725:728	arg1	administration					730:743	Oral administration	725:743	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice	725:810	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	6	38	dep	in	1653:1654	arg1	vitro					1656:1660	vitro	1656:1660	vitro	1656:1660	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	1	39	theme	algae	187:191	arg1	weight					134:139	high molecular weight (HMW) κ-	119:148	high molecular weight (HMW) κ-	119:148	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	39	theme	algae	187:191	arg1	λ-carrageenans					154:167	λ-carrageenans	154:167	λ-carrageenans of the red marine algae Chondrus armatus	154:208	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	39	theme	algae	187:191	arg1	LMWDPs					263:268	LMWDPs	263:268	LMWDPs	263:268	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	39	theme	algae	187:191	arg1	HMW					142:144	HMW	142:144	HMW	142:144	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	39	theme	algae	187:191	arg1	weight					234:239	their low molecular weight	214:239	their low molecular weight	214:239	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	0	40	theme	carrageenans	42:53	arg1	effects					14:20	Immunological effects	0:20	Immunological effects of Chondrus armatus carrageenans and their low molecular weight degradation products.	0:106	Immunological effects of Chondrus armatus carrageenans and their low molecular weight degradation products.
32985066	2	41	from	100 μg/ml	556:564	arg1	samples					545:551	all carrageenan samples	529:551	all carrageenan samples at 100 μg/ml	529:564	We demonstrated that, with an exception of one, all carrageenan samples at 100 μg/ml increased cellular motility and dose-dependently decreased phagocytic activity; LMWDPs of λ-carrageenan suppressed motility and had no effect on phagocytosis.
32985066	6	42	contain	possessing	1441:1450	arg2	efficacy					1459:1466	higher efficacy	1452:1466	higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions	1452:1683	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	6	42	contain	possessing	1441:1450	arg1	κ-samples					1431:1439	κ-samples	1431:1439	κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions	1431:1683	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	6	43	theme	higher	1452:1457	arg1	efficacy					1459:1466	higher efficacy	1452:1466	higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions	1452:1683	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	3	44	contain	had	812:814	arg2	effect					819:824	no effect	816:824	no effect	816:824	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	44	contain	had	812:814	arg1	administration					730:743	Oral administration	725:743	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice	725:810	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	45	theme	spleen	892:897	arg1	weight					869:874	weight	869:874	weight of their liver, spleen or thymus	869:907	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	45	theme	spleen	892:897	arg1	appearance					844:853	their clinical appearance	829:853	their clinical appearance	829:853	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	45	theme	spleen	892:897	arg1	weight					861:866	body weight	856:866	body weight	856:866	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	45	theme	spleen	892:897	arg1	development					912:922	development	912:922	development of noticeable changes to their inner organs	912:966	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	1	46	theme	Chondrus	193:200	arg1	algae					187:191	the red marine algae	172:191	the red marine algae Chondrus armatus	172:208	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	4	47	theme	peritoneal	1028:1037	arg1	cavity					1039:1044	the peritoneal cavity	1024:1044	the peritoneal cavity	1024:1044	All samples induced a shift of the cell composition of the peritoneal cavity towards macrophages.
32985066	3	48	theme	samples	768:774	arg1	administration					730:743	Oral administration	725:743	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice	725:810	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	6	49	theme	peritoneal	1393:1402	arg1	macrophages					1404:1414	peritoneal macrophages	1393:1414	peritoneal macrophages	1393:1414	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	1	50	theme	murine	374:379	arg1	macrophages					392:402	murine peritoneal macrophages	374:402	murine peritoneal macrophages	374:402	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	51	theme	weeklong	452:459	arg1	experiment					469:478	a weeklong feeding experiment	450:478	a weeklong feeding experiment	450:478	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	51	theme	weeklong	452:459	arg1	Ability					108:114	Ability	108:114	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages	108:402	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	5	52	theme	leukopenia	1133:1142	arg1	development					1118:1128	development	1118:1128	development of leukopenia	1118:1142	Consumption of LMWDPs of κ-carrageenan resulted in development of leukopenia, however, no changes to relative WBC count were introduced by either of the samples.
32985066	2	53	theme	carrageenan	533:543	arg1	samples					545:551	all carrageenan samples	529:551	all carrageenan samples at 100 μg/ml	529:564	We demonstrated that, with an exception of one, all carrageenan samples at 100 μg/ml increased cellular motility and dose-dependently decreased phagocytic activity; LMWDPs of λ-carrageenan suppressed motility and had no effect on phagocytosis.
32985066	1	54	theme	peritoneal	381:390	arg1	macrophages					392:402	murine peritoneal macrophages	374:402	murine peritoneal macrophages	374:402	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	0	55	dep	carrageenans	42:53	arg1	products					98:105	degradation products	86:105	degradation products	86:105	Immunological effects of Chondrus armatus carrageenans and their low molecular weight degradation products.
32985066	1	56	theme	feeding	461:467	arg1	experiment					469:478	a weeklong feeding experiment	450:478	a weeklong feeding experiment	450:478	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	56	theme	feeding	461:467	arg1	Ability					108:114	Ability	108:114	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages	108:402	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	57	theme	high	119:122	arg1	weight					134:139	high molecular weight (HMW) κ-	119:148	high molecular weight (HMW) κ-	119:148	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	57	theme	high	119:122	arg1	LMWDPs					263:268	LMWDPs	263:268	LMWDPs	263:268	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	57	theme	high	119:122	arg1	HMW					142:144	HMW	142:144	HMW	142:144	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	6	58	theme	macrophages	1269:1279	arg1	activity					1292:1299	murine peritoneal macrophages phagocytic activity	1251:1299	murine peritoneal macrophages phagocytic activity	1251:1299	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	1	59	theme	macrophages	392:402	arg1	motility					344:351	motility	344:351	motility	344:351	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	59	theme	macrophages	392:402	arg1	properties					332:341	functional properties	321:341	functional properties (motility and phagocytosis) of murine peritoneal macrophages	321:402	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	59	theme	macrophages	392:402	arg1	phagocytosis					357:368	phagocytosis	357:368	phagocytosis	357:368	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	6	60	theme	in	1666:1667	arg1	conditions					1674:1683	both in vitro and in vivo conditions	1648:1683	both in vitro and in vivo conditions	1648:1683	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	1	61	theme	molecular	124:132	arg1	weight					134:139	high molecular weight (HMW) κ-	119:148	high molecular weight (HMW) κ-	119:148	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	61	theme	molecular	124:132	arg1	LMWDPs					263:268	LMWDPs	263:268	LMWDPs	263:268	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	61	theme	molecular	124:132	arg1	HMW					142:144	HMW	142:144	HMW	142:144	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	3	62	theme	clinical	835:842	arg1	appearance					844:853	their clinical appearance	829:853	their clinical appearance	829:853	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	63	theme	carrageenan	756:766	arg1	samples					768:774	all the carrageenan samples	748:774	all the carrageenan samples	748:774	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	6	64	theme	peritoneal	1258:1267	arg1	macrophages					1269:1279	murine peritoneal macrophages	1251:1279	murine peritoneal macrophages phagocytic activity	1251:1299	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	1	65	dep	Chondrus	193:200	arg1	armatus					202:208	armatus	202:208	armatus	202:208	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	0	66	dep	Chondrus	25:32	arg1	armatus					34:40	armatus	34:40	armatus	34:40	Immunological effects of Chondrus armatus carrageenans and their low molecular weight degradation products.
32985066	1	67	theme	weight	134:139	arg1	experiment					469:478	a weeklong feeding experiment	450:478	a weeklong feeding experiment	450:478	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	67	theme	weight	134:139	arg1	Ability					108:114	Ability	108:114	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages	108:402	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	1	67	theme	weight	134:139	arg1	in					437:438	in	437:438	in	437:438	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	2	68	theme	one	524:526	arg1	exception					511:519	an exception	508:519	an exception of one	508:526	We demonstrated that, with an exception of one, all carrageenan samples at 100 μg/ml increased cellular motility and dose-dependently decreased phagocytic activity; LMWDPs of λ-carrageenan suppressed motility and had no effect on phagocytosis.
32985066	6	69	theme	armatus	1560:1566	arg1	κ-					1528:1529	κ-	1528:1529	κ-	1528:1529	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	6	69	theme	armatus	1560:1566	arg1	λ-carrageenans					1535:1548	λ-carrageenans	1535:1548	λ-carrageenans	1535:1548	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	6	70	theme	peritoneal	1619:1628	arg1	macrophages					1630:1640	peritoneal macrophages	1619:1640	peritoneal macrophages	1619:1640	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	6	71	theme	LMWDPs	1578:1583	arg1	κ-					1528:1529	κ-	1528:1529	κ-	1528:1529	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	6	71	theme	LMWDPs	1578:1583	arg1	λ-carrageenans					1535:1548	λ-carrageenans	1535:1548	λ-carrageenans	1535:1548	All samples decreased murine peritoneal macrophages phagocytic activity, with λ-samples possessing higher efficacy than their κ-counterparts; all LMWDPs stimulated peritoneal macrophages motility, with κ-samples possessing higher efficacy than their λ-counterparts In conclusion, we have shown that κ- and λ-carrageenans of the C. armatus and their LMWDPs suppress phagocytotic activity of peritoneal macrophages under both in vitro and in vivo conditions.
32985066	0	72	theme	molecular	69:77	arg1	weight					79:84	their low molecular weight	59:84	their low molecular weight	59:84	Immunological effects of Chondrus armatus carrageenans and their low molecular weight degradation products.
32985066	4	73	theme	composition	1009:1019	arg1	shift					991:995	a shift	989:995	a shift of the cell composition of the peritoneal cavity towards macrophages	989:1064	All samples induced a shift of the cell composition of the peritoneal cavity towards macrophages.
32985066	3	74	theme	inner	955:959	arg1	organs					961:966	their inner organs	949:966	their inner organs	949:966	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	4	75	theme	cavity	1039:1044	arg1	composition					1009:1019	the cell composition	1000:1019	the cell composition of the peritoneal cavity	1000:1044	All samples induced a shift of the cell composition of the peritoneal cavity towards macrophages.
32985066	1	76	theme	low	220:222	arg1	weight					234:239	their low molecular weight	214:239	their low molecular weight	214:239	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32985066	0	77	theme	low	65:67	arg1	weight					79:84	their low molecular weight	59:84	their low molecular weight	59:84	Immunological effects of Chondrus armatus carrageenans and their low molecular weight degradation products.
32985066	5	78	theme	LMWDPs	1082:1087	arg1	Consumption					1067:1077	Consumption	1067:1077	Consumption of LMWDPs of κ-carrageenan	1067:1104	Consumption of LMWDPs of κ-carrageenan resulted in development of leukopenia, however, no changes to relative WBC count were introduced by either of the samples.
32985066	3	79	theme	changes	938:944	arg1	weight					869:874	weight	869:874	weight of their liver, spleen or thymus	869:907	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	79	theme	changes	938:944	arg1	appearance					844:853	their clinical appearance	829:853	their clinical appearance	829:853	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	79	theme	changes	938:944	arg1	weight					861:866	body weight	856:866	body weight	856:866	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	3	79	theme	changes	938:944	arg1	development					912:922	development	912:922	development of noticeable changes to their inner organs	912:966	Oral administration of all the carrageenan samples at 100 μg/kg/day for 7 days to mice had no effect on their clinical appearance, body weight, weight of their liver, spleen or thymus or development of noticeable changes to their inner organs.
32985066	4	80	theme	cell	1004:1007	arg1	composition					1009:1019	the cell composition	1000:1019	the cell composition of the peritoneal cavity	1000:1044	All samples induced a shift of the cell composition of the peritoneal cavity towards macrophages.
32985066	1	81	theme	molecular	224:232	arg1	weight					234:239	their low molecular weight	214:239	their low molecular weight	214:239	Ability of high molecular weight (HMW) κ- and λ-carrageenans of the red marine algae Chondrus armatus and their low molecular weight degradation products (LMWDPs) (0.7-20 and 10-170 kDa respectively) to influence functional properties (motility and phagocytosis) of murine peritoneal macrophages was assessed in this study as an in vitro and a weeklong feeding experiment.
32707281	6	0	theme	biochemicals	975:986	arg1	levels					959:964	levels	959:964	levels of serum biochemicals	959:986	Analysis of general health status and levels of serum biochemicals revealed that mice with consecutive supplementation of GMs for 14 days performed normally compared with those in control group.
32707281	6	0	theme	biochemicals	975:986	arg1	Analysis					921:928	Analysis	921:928	Analysis of general health status	921:953	Analysis of general health status and levels of serum biochemicals revealed that mice with consecutive supplementation of GMs for 14 days performed normally compared with those in control group.
32707281	5	1	theme	intestinal	861:870	arg1	production					878:887	intestinal SCFAs production	861:887	intestinal SCFAs production	861:887	Then, effects of the six GMs on general health status, serum biochemicals, and intestinal SCFAs production in mice were evaluated in vivo.
32707281	9	2	theme	molecular	1541:1549	arg1	weight					1551:1556	molecular weight	1541:1556	molecular weight	1541:1556	The current investigation suggested that both functional and intestinal fermentation property of GMs were jointly determined by the monosaccharide composition, molecular weight, and degree of acetylation.
32707281	8	3	contain	having	1337:1342	arg2	Mw					1351:1352	higher Mw	1344:1352	higher Mw	1344:1352	Generally, higher concentrations of SCFAs were produced when mice were treated with GMs having higher Mw, ratio of glucose, and DA.
32707281	8	3	contain	having	1337:1342	arg2	DA					1377:1378	DA	1377:1378	DA	1377:1378	Generally, higher concentrations of SCFAs were produced when mice were treated with GMs having higher Mw, ratio of glucose, and DA.
32707281	8	3	contain	having	1337:1342	arg2	ratio					1355:1359	ratio	1355:1359	ratio of glucose	1355:1370	Generally, higher concentrations of SCFAs were produced when mice were treated with GMs having higher Mw, ratio of glucose, and DA.
32707281	8	3	contain	having	1337:1342	arg1	GMs					1333:1335	GMs	1333:1335	GMs having higher Mw, ratio of glucose, and DA	1333:1378	Generally, higher concentrations of SCFAs were produced when mice were treated with GMs having higher Mw, ratio of glucose, and DA.
32707281	0	4	from	study	12:16	arg1	glucomannans					21:32	glucomannans	21:32	glucomannans with different structural characteristics	21:74	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	5	5	theme	SCFAs	872:876	arg1	production					878:887	intestinal SCFAs production	861:887	intestinal SCFAs production	861:887	Then, effects of the six GMs on general health status, serum biochemicals, and intestinal SCFAs production in mice were evaluated in vivo.
32707281	9	6	theme	intestinal	1442:1451	arg1	property					1466:1473	both functional and intestinal fermentation property	1422:1473	both functional and intestinal fermentation property of GMs	1422:1480	The current investigation suggested that both functional and intestinal fermentation property of GMs were jointly determined by the monosaccharide composition, molecular weight, and degree of acetylation.
32707281	7	7	dep	SCFAs	1150:1154	arg1	butyrate					1176:1183	butyrate	1176:1183	butyrate	1176:1183	Interestingly, the productions of SCFAs (mainly acetate and butyrate) in the cecal and colonic contents were significantly promoted.
32707281	7	7	dep	SCFAs	1150:1154	arg1	acetate					1164:1170	acetate	1164:1170	acetate	1164:1170	Interestingly, the productions of SCFAs (mainly acetate and butyrate) in the cecal and colonic contents were significantly promoted.
32707281	9	8	theme	monosaccharide	1513:1526	arg1	composition					1528:1538	the monosaccharide composition	1509:1538	the monosaccharide composition	1509:1538	The current investigation suggested that both functional and intestinal fermentation property of GMs were jointly determined by the monosaccharide composition, molecular weight, and degree of acetylation.
32707281	2	9	theme	GMs	313:315	arg1	properties					299:308	functional properties	288:308	functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe	288:448	In current study, functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe were determined.
32707281	8	10	theme	higher	1344:1349	arg1	Mw					1351:1352	higher Mw	1344:1352	higher Mw	1344:1352	Generally, higher concentrations of SCFAs were produced when mice were treated with GMs having higher Mw, ratio of glucose, and DA.
32707281	0	11	theme	intestinal	103:112	arg1	production					114:123	intestinal production	103:123	intestinal production	103:123	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	7	12	from	productions	1135:1145	arg1	contents					1211:1218	the cecal and colonic contents	1189:1218	the cecal and colonic contents	1189:1218	Interestingly, the productions of SCFAs (mainly acetate and butyrate) in the cecal and colonic contents were significantly promoted.
32707281	6	13	theme	status	948:953	arg1	levels					959:964	levels	959:964	levels of serum biochemicals	959:986	Analysis of general health status and levels of serum biochemicals revealed that mice with consecutive supplementation of GMs for 14 days performed normally compared with those in control group.
32707281	6	13	theme	status	948:953	arg1	Analysis					921:928	Analysis	921:928	Analysis of general health status	921:953	Analysis of general health status and levels of serum biochemicals revealed that mice with consecutive supplementation of GMs for 14 days performed normally compared with those in control group.
32707281	0	14	theme	short	128:132	arg1	acids					146:150	short chain fatty acids	128:150	short chain fatty acids	128:150	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	8	15	theme	higher	1260:1265	arg1	concentrations					1267:1280	higher concentrations	1260:1280	higher concentrations of SCFAs	1260:1289	Generally, higher concentrations of SCFAs were produced when mice were treated with GMs having higher Mw, ratio of glucose, and DA.
32707281	6	16	theme	consecutive	1012:1022	arg1	supplementation					1024:1038	consecutive supplementation	1012:1038	consecutive supplementation of GMs for 14 days	1012:1057	Analysis of general health status and levels of serum biochemicals revealed that mice with consecutive supplementation of GMs for 14 days performed normally compared with those in control group.
32707281	3	17	theme	GMs	516:518	arg1	Mw					509:510	Mw	509:510	Mw	509:510	Results suggested that molecular weights (Mw) of GMs were positively correlated with their water absorption capacity, fat absorption capacity, and viscosity, while ratio of mannose/glucose showed negative effect.
32707281	3	17	theme	GMs	516:518	arg1	weights					500:506	molecular weights	490:506	molecular weights (Mw) of GMs	490:518	Results suggested that molecular weights (Mw) of GMs were positively correlated with their water absorption capacity, fat absorption capacity, and viscosity, while ratio of mannose/glucose showed negative effect.
32707281	5	18	theme	serum	837:841	arg1	biochemicals					843:854	serum biochemicals	837:854	serum biochemicals	837:854	Then, effects of the six GMs on general health status, serum biochemicals, and intestinal SCFAs production in mice were evaluated in vivo.
32707281	5	19	from	effects	788:794	arg1	status					829:834	general health status	814:834	general health status	814:834	Then, effects of the six GMs on general health status, serum biochemicals, and intestinal SCFAs production in mice were evaluated in vivo.
32707281	5	19	from	effects	788:794	arg1	production					878:887	intestinal SCFAs production	861:887	intestinal SCFAs production	861:887	Then, effects of the six GMs on general health status, serum biochemicals, and intestinal SCFAs production in mice were evaluated in vivo.
32707281	5	19	from	effects	788:794	arg1	biochemicals					843:854	serum biochemicals	837:854	serum biochemicals	837:854	Then, effects of the six GMs on general health status, serum biochemicals, and intestinal SCFAs production in mice were evaluated in vivo.
32707281	9	20	theme	GMs	1478:1480	arg1	property					1466:1473	both functional and intestinal fermentation property	1422:1473	both functional and intestinal fermentation property of GMs	1422:1480	The current investigation suggested that both functional and intestinal fermentation property of GMs were jointly determined by the monosaccharide composition, molecular weight, and degree of acetylation.
32707281	2	21	theme	functional	288:297	arg1	properties					299:308	functional properties	288:308	functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe	288:448	In current study, functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe were determined.
32707281	1	22	theme	abundant	177:184	arg1	resources					194:202	abundant natural resources	177:202	abundant natural resources	177:202	Glucomannans (GMs) from abundant natural resources have excellent processing properties and plentiful bioactivities.
32707281	7	23	theme	SCFAs	1150:1154	arg1	productions					1135:1145	the productions	1131:1145	the productions of SCFAs (mainly acetate and butyrate) in the cecal and colonic contents	1131:1218	Interestingly, the productions of SCFAs (mainly acetate and butyrate) in the cecal and colonic contents were significantly promoted.
32707281	2	24	from	konjac	379:384	arg1	KGM					370:372	KGM	370:372	KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe	370:448	In current study, functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe were determined.
32707281	3	25	theme	water	558:562	arg1	capacity					575:582	their water absorption capacity	552:582	their water absorption capacity	552:582	Results suggested that molecular weights (Mw) of GMs were positively correlated with their water absorption capacity, fat absorption capacity, and viscosity, while ratio of mannose/glucose showed negative effect.
32707281	1	26	theme	natural	186:192	arg1	resources					194:202	abundant natural resources	177:202	abundant natural resources	177:202	Glucomannans (GMs) from abundant natural resources have excellent processing properties and plentiful bioactivities.
32707281	0	27	theme	Comparative	0:10	arg1	study					12:16	Comparative study	0:16	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.	0:151	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	6	28	theme	health	941:946	arg1	status					948:953	general health status	933:953	general health status	933:953	Analysis of general health status and levels of serum biochemicals revealed that mice with consecutive supplementation of GMs for 14 days performed normally compared with those in control group.
32707281	5	29	from	production	878:887	arg1	mice					892:895	mice	892:895	mice	892:895	Then, effects of the six GMs on general health status, serum biochemicals, and intestinal SCFAs production in mice were evaluated in vivo.
32707281	2	30	theme	structural	332:341	arg1	KGM					370:372	KGM	370:372	KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe	370:448	In current study, functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe were determined.
32707281	2	30	theme	structural	332:341	arg1	characteristics					343:357	different structural characteristics	322:357	different structural characteristics	322:357	In current study, functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe were determined.
32707281	5	31	from	biochemicals	843:854	arg1	mice					892:895	mice	892:895	mice	892:895	Then, effects of the six GMs on general health status, serum biochemicals, and intestinal SCFAs production in mice were evaluated in vivo.
32707281	2	32	theme	current	273:279	arg1	study					281:285	current study	273:285	current study	273:285	In current study, functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe were determined.
32707281	0	33	theme	fatty	140:144	arg1	acids					146:150	short chain fatty acids	128:150	short chain fatty acids	128:150	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	2	34	theme	different	322:330	arg1	KGM					370:372	KGM	370:372	KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe	370:448	In current study, functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe were determined.
32707281	2	34	theme	different	322:330	arg1	characteristics					343:357	different structural characteristics	322:357	different structural characteristics	322:357	In current study, functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe were determined.
32707281	5	35	theme	GMs	807:809	arg1	effects					788:794	effects	788:794	effects of the six GMs on general health status, serum biochemicals, and intestinal SCFAs production in mice	788:895	Then, effects of the six GMs on general health status, serum biochemicals, and intestinal SCFAs production in mice were evaluated in vivo.
32707281	3	36	theme	absorption	564:573	arg1	capacity					575:582	their water absorption capacity	552:582	their water absorption capacity	552:582	Results suggested that molecular weights (Mw) of GMs were positively correlated with their water absorption capacity, fat absorption capacity, and viscosity, while ratio of mannose/glucose showed negative effect.
32707281	9	37	theme	functional	1427:1436	arg1	property					1466:1473	both functional and intestinal fermentation property	1422:1473	both functional and intestinal fermentation property of GMs	1422:1480	The current investigation suggested that both functional and intestinal fermentation property of GMs were jointly determined by the monosaccharide composition, molecular weight, and degree of acetylation.
32707281	0	38	theme	chain	134:138	arg1	acids					146:150	short chain fatty acids	128:150	short chain fatty acids	128:150	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	7	39	theme	colonic	1203:1209	arg1	contents					1211:1218	the cecal and colonic contents	1189:1218	the cecal and colonic contents	1189:1218	Interestingly, the productions of SCFAs (mainly acetate and butyrate) in the cecal and colonic contents were significantly promoted.
32707281	1	40	theme	excellent	209:217	arg1	properties					230:239	excellent processing properties	209:239	excellent processing properties	209:239	Glucomannans (GMs) from abundant natural resources have excellent processing properties and plentiful bioactivities.
32707281	0	41	theme	different	39:47	arg1	characteristics					60:74	different structural characteristics	39:74	different structural characteristics	39:74	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	6	42	theme	control	1101:1107	arg1	group					1109:1113	control group	1101:1113	control group	1101:1113	Analysis of general health status and levels of serum biochemicals revealed that mice with consecutive supplementation of GMs for 14 days performed normally compared with those in control group.
32707281	9	43	theme	fermentation	1453:1464	arg1	property					1466:1473	both functional and intestinal fermentation property	1422:1473	both functional and intestinal fermentation property of GMs	1422:1480	The current investigation suggested that both functional and intestinal fermentation property of GMs were jointly determined by the monosaccharide composition, molecular weight, and degree of acetylation.
32707281	5	44	theme	general	814:820	arg1	status					829:834	general health status	814:834	general health status	814:834	Then, effects of the six GMs on general health status, serum biochemicals, and intestinal SCFAs production in mice were evaluated in vivo.
32707281	3	45	theme	fat	585:587	arg1	capacity					600:607	fat absorption capacity	585:607	fat absorption capacity	585:607	Results suggested that molecular weights (Mw) of GMs were positively correlated with their water absorption capacity, fat absorption capacity, and viscosity, while ratio of mannose/glucose showed negative effect.
32707281	1	46	theme	processing	219:228	arg1	properties					230:239	excellent processing properties	209:239	excellent processing properties	209:239	Glucomannans (GMs) from abundant natural resources have excellent processing properties and plentiful bioactivities.
32707281	6	47	theme	GMs	1043:1045	arg1	supplementation					1024:1038	consecutive supplementation	1012:1038	consecutive supplementation of GMs for 14 days	1012:1057	Analysis of general health status and levels of serum biochemicals revealed that mice with consecutive supplementation of GMs for 14 days performed normally compared with those in control group.
32707281	0	48	theme	acids	146:150	arg1	properties					88:97	Functional properties	77:97	Functional properties	77:97	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	0	48	theme	acids	146:150	arg1	production					114:123	intestinal production	103:123	intestinal production	103:123	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	3	49	theme	absorption	589:598	arg1	capacity					600:607	fat absorption capacity	585:607	fat absorption capacity	585:607	Results suggested that molecular weights (Mw) of GMs were positively correlated with their water absorption capacity, fat absorption capacity, and viscosity, while ratio of mannose/glucose showed negative effect.
32707281	0	50	with	glucomannans	21:32	arg1	characteristics					60:74	different structural characteristics	39:74	different structural characteristics	39:74	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	5	51	theme	health	822:827	arg1	status					829:834	general health status	814:834	general health status	814:834	Then, effects of the six GMs on general health status, serum biochemicals, and intestinal SCFAs production in mice were evaluated in vivo.
32707281	6	52	theme	general	933:939	arg1	status					948:953	general health status	933:953	general health status	933:953	Analysis of general health status and levels of serum biochemicals revealed that mice with consecutive supplementation of GMs for 14 days performed normally compared with those in control group.
32707281	8	53	theme	glucose	1364:1370	arg1	DA					1377:1378	DA	1377:1378	DA	1377:1378	Generally, higher concentrations of SCFAs were produced when mice were treated with GMs having higher Mw, ratio of glucose, and DA.
32707281	8	53	theme	glucose	1364:1370	arg1	ratio					1355:1359	ratio	1355:1359	ratio of glucose	1355:1370	Generally, higher concentrations of SCFAs were produced when mice were treated with GMs having higher Mw, ratio of glucose, and DA.
32707281	8	53	theme	glucose	1364:1370	arg1	Mw					1351:1352	higher Mw	1344:1352	higher Mw	1344:1352	Generally, higher concentrations of SCFAs were produced when mice were treated with GMs having higher Mw, ratio of glucose, and DA.
32707281	2	54	from	dendrobium	396:405	arg1	DOP					387:389	DOP	387:389	DOP from dendrobium	387:405	In current study, functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe were determined.
32707281	2	54	from	dendrobium	396:405	arg1	konjac					379:384	konjac	379:384	konjac	379:384	In current study, functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe were determined.
32707281	3	55	theme	molecular	490:498	arg1	Mw					509:510	Mw	509:510	Mw	509:510	Results suggested that molecular weights (Mw) of GMs were positively correlated with their water absorption capacity, fat absorption capacity, and viscosity, while ratio of mannose/glucose showed negative effect.
32707281	3	55	theme	molecular	490:498	arg1	weights					500:506	molecular weights	490:506	molecular weights (Mw) of GMs	490:518	Results suggested that molecular weights (Mw) of GMs were positively correlated with their water absorption capacity, fat absorption capacity, and viscosity, while ratio of mannose/glucose showed negative effect.
32707281	0	56	theme	structural	49:58	arg1	characteristics					60:74	different structural characteristics	39:74	different structural characteristics	39:74	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	3	57	theme	negative	663:670	arg1	effect					672:677	negative effect	663:677	negative effect	663:677	Results suggested that molecular weights (Mw) of GMs were positively correlated with their water absorption capacity, fat absorption capacity, and viscosity, while ratio of mannose/glucose showed negative effect.
32707281	9	58	theme	acetylation	1573:1583	arg1	composition					1528:1538	the monosaccharide composition	1509:1538	the monosaccharide composition	1509:1538	The current investigation suggested that both functional and intestinal fermentation property of GMs were jointly determined by the monosaccharide composition, molecular weight, and degree of acetylation.
32707281	9	58	theme	acetylation	1573:1583	arg1	weight					1551:1556	molecular weight	1541:1556	molecular weight	1541:1556	The current investigation suggested that both functional and intestinal fermentation property of GMs were jointly determined by the monosaccharide composition, molecular weight, and degree of acetylation.
32707281	9	58	theme	acetylation	1573:1583	arg1	degree					1563:1568	degree	1563:1568	degree of acetylation	1563:1583	The current investigation suggested that both functional and intestinal fermentation property of GMs were jointly determined by the monosaccharide composition, molecular weight, and degree of acetylation.
32707281	4	59	theme	acetylation	697:707	arg1	degree					687:692	Higher degree	680:692	Higher degree of acetylation (DA)	680:712	Higher degree of acetylation (DA) mainly corresponded to higher values of solubility and ζ-potential.
32707281	2	60	from	aloe	445:448	arg1	KGM					370:372	KGM	370:372	KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe	370:448	In current study, functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe were determined.
32707281	6	61	with	mice	1002:1005	arg1	supplementation					1024:1038	consecutive supplementation	1012:1038	consecutive supplementation of GMs for 14 days	1012:1057	Analysis of general health status and levels of serum biochemicals revealed that mice with consecutive supplementation of GMs for 14 days performed normally compared with those in control group.
32707281	4	62	theme	higher	737:742	arg1	values					744:749	higher values	737:749	higher values of solubility and ζ-potential	737:779	Higher degree of acetylation (DA) mainly corresponded to higher values of solubility and ζ-potential.
32707281	4	63	theme	solubility	754:763	arg1	values					744:749	higher values	737:749	higher values of solubility and ζ-potential	737:779	Higher degree of acetylation (DA) mainly corresponded to higher values of solubility and ζ-potential.
32707281	3	64	theme	mannose/glucose	640:654	arg1	ratio					631:635	ratio	631:635	ratio of mannose/glucose	631:654	Results suggested that molecular weights (Mw) of GMs were positively correlated with their water absorption capacity, fat absorption capacity, and viscosity, while ratio of mannose/glucose showed negative effect.
32707281	4	65	theme	ζ-potential	769:779	arg1	values					744:749	higher values	737:749	higher values of solubility and ζ-potential	737:779	Higher degree of acetylation (DA) mainly corresponded to higher values of solubility and ζ-potential.
32707281	1	66	theme	plentiful	245:253	arg1	bioactivities					255:267	plentiful bioactivities	245:267	plentiful bioactivities	245:267	Glucomannans (GMs) from abundant natural resources have excellent processing properties and plentiful bioactivities.
32707281	0	67	theme	Functional	77:86	arg1	properties					88:97	Functional properties	77:97	Functional properties	77:97	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	1	68	contain	have	204:207	arg2	properties					230:239	excellent processing properties	209:239	excellent processing properties	209:239	Glucomannans (GMs) from abundant natural resources have excellent processing properties and plentiful bioactivities.
32707281	1	68	contain	have	204:207	arg1	GMs					167:169	GMs	167:169	GMs	167:169	Glucomannans (GMs) from abundant natural resources have excellent processing properties and plentiful bioactivities.
32707281	1	68	contain	have	204:207	arg1	Glucomannans					153:164	Glucomannans	153:164	Glucomannans (GMs) from abundant natural resources	153:202	Glucomannans (GMs) from abundant natural resources have excellent processing properties and plentiful bioactivities.
32707281	1	68	contain	have	204:207	arg2	bioactivities					255:267	plentiful bioactivities	245:267	plentiful bioactivities	245:267	Glucomannans (GMs) from abundant natural resources have excellent processing properties and plentiful bioactivities.
32707281	0	69	dep	study	12:16	arg1	properties					88:97	Functional properties	77:97	Functional properties	77:97	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	0	69	dep	study	12:16	arg1	production					114:123	intestinal production	103:123	intestinal production	103:123	Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids.
32707281	1	70	from	resources	194:202	arg1	GMs					167:169	GMs	167:169	GMs	167:169	Glucomannans (GMs) from abundant natural resources have excellent processing properties and plentiful bioactivities.
32707281	1	70	from	resources	194:202	arg1	Glucomannans					153:164	Glucomannans	153:164	Glucomannans (GMs) from abundant natural resources	153:202	Glucomannans (GMs) from abundant natural resources have excellent processing properties and plentiful bioactivities.
32707281	4	71	theme	Higher	680:685	arg1	degree					687:692	Higher degree	680:692	Higher degree of acetylation (DA)	680:712	Higher degree of acetylation (DA) mainly corresponded to higher values of solubility and ζ-potential.
32707281	9	72	theme	current	1385:1391	arg1	investigation					1393:1405	The current investigation	1381:1405	The current investigation	1381:1405	The current investigation suggested that both functional and intestinal fermentation property of GMs were jointly determined by the monosaccharide composition, molecular weight, and degree of acetylation.
32707281	2	73	with	GMs	313:315	arg1	KGM					370:372	KGM	370:372	KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe	370:448	In current study, functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe were determined.
32707281	2	73	with	GMs	313:315	arg1	characteristics					343:357	different structural characteristics	322:357	different structural characteristics	322:357	In current study, functional properties of GMs with different structural characteristics, including KGM from konjac, DOP from dendrobium, AGP40, ASP-4N, ASP-6N, & ASP-8N from aloe were determined.
32707281	7	74	theme	cecal	1193:1197	arg1	contents					1211:1218	the cecal and colonic contents	1189:1218	the cecal and colonic contents	1189:1218	Interestingly, the productions of SCFAs (mainly acetate and butyrate) in the cecal and colonic contents were significantly promoted.
32707281	5	75	from	status	829:834	arg1	mice					892:895	mice	892:895	mice	892:895	Then, effects of the six GMs on general health status, serum biochemicals, and intestinal SCFAs production in mice were evaluated in vivo.
32707281	8	76	theme	SCFAs	1285:1289	arg1	concentrations					1267:1280	higher concentrations	1260:1280	higher concentrations of SCFAs	1260:1289	Generally, higher concentrations of SCFAs were produced when mice were treated with GMs having higher Mw, ratio of glucose, and DA.
32707281	6	77	theme	serum	969:973	arg1	biochemicals					975:986	serum biochemicals	969:986	serum biochemicals	969:986	Analysis of general health status and levels of serum biochemicals revealed that mice with consecutive supplementation of GMs for 14 days performed normally compared with those in control group.
32329760	1	0	theme	protic	273:278	arg1	media					286:290	protic polar media	273:290	protic polar media	273:290	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	2	1	theme	aggregates	381:390	arg1	formation					335:343	the formation	331:343	the formation of complex hierarchical luminescent aggregates, wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure	331:510	The results demonstrate the formation of complex hierarchical luminescent aggregates, wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure.
32329760	1	2	theme	polar	280:284	arg1	media					286:290	protic polar media	273:290	protic polar media	273:290	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	0	3	from	4-amino-	74:81	arg1	self-assemblies					40:54	Fluorescent supramolecular hierarchical self-assemblies	0:54	Fluorescent supramolecular hierarchical self-assemblies from glycosylated 4-amino- and 4-bromo-1,8-naphthalimides.	0:113	Fluorescent supramolecular hierarchical self-assemblies from glycosylated 4-amino- and 4-bromo-1,8-naphthalimides.
32329760	1	4	theme	based	209:213	arg1	1-3					227:229	1-3	227:229	1-3	227:229	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	1	4	theme	based	209:213	arg1	structures					215:224	two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures	158:224	two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3)	158:230	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	2	5	theme	Nap	498:500	arg1	structure					502:510	the Nap structure	494:510	the Nap structure	494:510	The results demonstrate the formation of complex hierarchical luminescent aggregates, wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure.
32329760	2	6	dep	wherein	393:399	arg1	dependent					462:470	dependent	462:470	dependent	462:470	The results demonstrate the formation of complex hierarchical luminescent aggregates, wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure.
32329760	2	6	dep	wherein	393:399	arg1	morphologies					405:416	the morphologies	401:416	the morphologies	401:416	The results demonstrate the formation of complex hierarchical luminescent aggregates, wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure.
32329760	1	7	theme	structures	215:224	arg1	self-assembly					141:153	the self-assembly	137:153	the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media,	137:291	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	0	8	theme	supramolecular	12:25	arg1	self-assemblies					40:54	Fluorescent supramolecular hierarchical self-assemblies	0:54	Fluorescent supramolecular hierarchical self-assemblies from glycosylated 4-amino- and 4-bromo-1,8-naphthalimides.	0:113	Fluorescent supramolecular hierarchical self-assemblies from glycosylated 4-amino- and 4-bromo-1,8-naphthalimides.
32329760	0	9	theme	Fluorescent	0:10	arg1	self-assemblies					40:54	Fluorescent supramolecular hierarchical self-assemblies	0:54	Fluorescent supramolecular hierarchical self-assemblies from glycosylated 4-amino- and 4-bromo-1,8-naphthalimides.	0:113	Fluorescent supramolecular hierarchical self-assemblies from glycosylated 4-amino- and 4-bromo-1,8-naphthalimides.
32329760	1	10	from	media	286:290	arg1	1-3					227:229	1-3	227:229	1-3	227:229	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	1	10	from	media	286:290	arg1	self-assembly					141:153	the self-assembly	137:153	the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media,	137:291	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	1	10	from	media	286:290	arg1	structures					215:224	two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures	158:224	two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3)	158:230	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	0	11	theme	hierarchical	27:38	arg1	self-assemblies					40:54	Fluorescent supramolecular hierarchical self-assemblies	0:54	Fluorescent supramolecular hierarchical self-assemblies from glycosylated 4-amino- and 4-bromo-1,8-naphthalimides.	0:113	Fluorescent supramolecular hierarchical self-assemblies from glycosylated 4-amino- and 4-bromo-1,8-naphthalimides.
32329760	3	12	theme	native	531:536	arg1	bond					549:552	the native glycosidic bond	527:552	the native glycosidic bond	527:552	Upon cleaving the native glycosidic bond, using an enzyme, the structure/morphology of the self-assembly of 3 in buffered solution was significantly transformed.
32329760	0	13	theme	glycosylated	61:72	arg1	4-amino-					74:81	4-amino-	74:81	4-amino-	74:81	Fluorescent supramolecular hierarchical self-assemblies from glycosylated 4-amino- and 4-bromo-1,8-naphthalimides.
32329760	2	14	theme	hierarchical	356:367	arg1	wherein					393:399	wherein	393:399	wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure	393:510	The results demonstrate the formation of complex hierarchical luminescent aggregates, wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure.
32329760	2	14	theme	hierarchical	356:367	arg1	aggregates					381:390	complex hierarchical luminescent aggregates	348:390	complex hierarchical luminescent aggregates	348:390	The results demonstrate the formation of complex hierarchical luminescent aggregates, wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure.
32329760	3	15	theme	3	621:621	arg1	self-assembly					604:616	the self-assembly	600:616	the self-assembly of 3	600:621	Upon cleaving the native glycosidic bond, using an enzyme, the structure/morphology of the self-assembly of 3 in buffered solution was significantly transformed.
32329760	1	16	theme	appended	246:253	arg1	unit					262:265	an appended glycan unit	243:265	an appended glycan unit	243:265	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	0	17	from	4-bromo-1,8-naphthalimides	87:112	arg1	self-assemblies					40:54	Fluorescent supramolecular hierarchical self-assemblies	0:54	Fluorescent supramolecular hierarchical self-assemblies from glycosylated 4-amino- and 4-bromo-1,8-naphthalimides.	0:113	Fluorescent supramolecular hierarchical self-assemblies from glycosylated 4-amino- and 4-bromo-1,8-naphthalimides.
32329760	1	18	dep	based	209:213	arg1	Nap					204:206	Nap	204:206	Nap	204:206	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	1	18	dep	based	209:213	arg1	4-bromo-1,8-naphthalimide					177:201	a 4-bromo-1,8-naphthalimide	175:201	a 4-bromo-1,8-naphthalimide (Nap)	175:207	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	2	19	theme	luminescent	369:379	arg1	wherein					393:399	wherein	393:399	wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure	393:510	The results demonstrate the formation of complex hierarchical luminescent aggregates, wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure.
32329760	2	19	theme	luminescent	369:379	arg1	aggregates					381:390	complex hierarchical luminescent aggregates	348:390	complex hierarchical luminescent aggregates	348:390	The results demonstrate the formation of complex hierarchical luminescent aggregates, wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure.
32329760	3	20	theme	self-assembly	604:616	arg1	structure/morphology					576:595	the structure/morphology	572:595	the structure/morphology of the self-assembly of 3 in buffered solution	572:642	Upon cleaving the native glycosidic bond, using an enzyme, the structure/morphology of the self-assembly of 3 in buffered solution was significantly transformed.
32329760	1	21	theme	4-amino-	162:169	arg1	1-3					227:229	1-3	227:229	1-3	227:229	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	1	21	theme	4-amino-	162:169	arg1	structures					215:224	two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures	158:224	two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3)	158:230	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	1	22	from	self-assembly	141:153	arg1	media					286:290	protic polar media	273:290	protic polar media	273:290	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	2	23	theme	complex	348:354	arg1	wherein					393:399	wherein	393:399	wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure	393:510	The results demonstrate the formation of complex hierarchical luminescent aggregates, wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure.
32329760	2	23	theme	complex	348:354	arg1	aggregates					381:390	complex hierarchical luminescent aggregates	348:390	complex hierarchical luminescent aggregates	348:390	The results demonstrate the formation of complex hierarchical luminescent aggregates, wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure.
32329760	1	24	theme	glycan	255:260	arg1	unit					262:265	an appended glycan unit	243:265	an appended glycan unit	243:265	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	1	25	contain	possessing	232:241	arg1	1-3					227:229	1-3	227:229	1-3	227:229	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	1	25	contain	possessing	232:241	arg1	structures					215:224	two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures	158:224	two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3)	158:230	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	1	25	contain	possessing	232:241	arg2	unit					262:265	an appended glycan unit	243:265	an appended glycan unit	243:265	An investigation into the self-assembly of two 4-amino- and a 4-bromo-1,8-naphthalimide (Nap) based structures (1-3) possessing an appended glycan unit, from protic polar media, is presented.
32329760	0	26	gly	glycosylated	61:72	arg1	4-amino-					74:81	4-amino-	74:81	4-amino-	74:81	Fluorescent supramolecular hierarchical self-assemblies from glycosylated 4-amino- and 4-bromo-1,8-naphthalimides.
32329760	3	27	from	structure/morphology	576:595	arg1	solution					635:642	buffered solution	626:642	buffered solution	626:642	Upon cleaving the native glycosidic bond, using an enzyme, the structure/morphology of the self-assembly of 3 in buffered solution was significantly transformed.
32329760	2	28	theme	spherical	429:437	arg1	structures					439:448	spherical structures	429:448	spherical structures	429:448	The results demonstrate the formation of complex hierarchical luminescent aggregates, wherein the morphologies, sizes and spherical structures were highly dependent on both the media and the Nap structure.
32329760	3	29	theme	glycosidic	538:547	arg1	bond					549:552	the native glycosidic bond	527:552	the native glycosidic bond	527:552	Upon cleaving the native glycosidic bond, using an enzyme, the structure/morphology of the self-assembly of 3 in buffered solution was significantly transformed.
32329760	3	30	theme	buffered	626:633	arg1	solution					635:642	buffered solution	626:642	buffered solution	626:642	Upon cleaving the native glycosidic bond, using an enzyme, the structure/morphology of the self-assembly of 3 in buffered solution was significantly transformed.
34280853	2	0	from	%	370:370	arg1	comparison					399:408	comparison	399:408	comparison to 7.96% at 170 °C by autohydrolysis (AH) alone	399:456	The total XOS yield with optimum ozone dose of 3% (OAAH-3) was found to be 8.9% (w/w biomass) at 110 °C in comparison to 7.96% at 170 °C by autohydrolysis (AH) alone.
34280853	5	1	theme	treatment	959:967	arg1	temperature					969:979	treatment temperature	959:979	treatment temperature	959:979	PCA plots indicated clear enhancement in XOS production and lower generation of inhibitors with decrease in treatment temperature.
34280853	1	2	theme	present	156:162	arg1	study					164:168	the present study	152:168	the present study	152:168	In the present study, ozone assisted autohydrolysis (OAAH) was evaluated for enhanced generation of xylooligosaccharide (XOS) from wheat bran.
34280853	0	3	theme	low	89:91	arg1	generation					93:102	low generation	89:102	low generation of inhibitor compounds	89:125	Ozone assisted autohydrolysis of wheat bran enhances xylooligosaccharide production with low generation of inhibitor compounds: A comparative study.
34280853	5	4	theme	inhibitors	931:940	arg1	generation					917:926	lower generation	911:926	lower generation of inhibitors	911:940	PCA plots indicated clear enhancement in XOS production and lower generation of inhibitors with decrease in treatment temperature.
34280853	5	4	theme	inhibitors	931:940	arg1	enhancement					877:887	clear enhancement	871:887	clear enhancement in XOS production	871:905	PCA plots indicated clear enhancement in XOS production and lower generation of inhibitors with decrease in treatment temperature.
34280853	1	5	theme	xylooligosaccharide	249:267	arg1	generation					235:244	enhanced generation	226:244	enhanced generation of xylooligosaccharide (XOS) from wheat bran	226:289	In the present study, ozone assisted autohydrolysis (OAAH) was evaluated for enhanced generation of xylooligosaccharide (XOS) from wheat bran.
34280853	0	6	theme	inhibitor	107:115	arg1	compounds					117:125	inhibitor compounds	107:125	inhibitor compounds	107:125	Ozone assisted autohydrolysis of wheat bran enhances xylooligosaccharide production with low generation of inhibitor compounds: A comparative study.
34280853	3	7	theme	pretreatment	708:719	arg1	decrease					553:560	significant decrease	541:560	significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold),	541:676	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	7	theme	pretreatment	708:719	arg1	option					721:726	a pretreatment option	706:726	a pretreatment option	706:726	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	4	8	theme	scavenging	822:831	arg1	activity					833:840	higher DPPH radical scavenging activity	802:840	higher DPPH radical scavenging activity	802:840	There was 1-fold higher xylan to XOS conversion and OAAH-hydrolysate had higher DPPH radical scavenging activity than AH.
34280853	4	9	theme	higher	802:807	arg1	activity					833:840	higher DPPH radical scavenging activity	802:840	higher DPPH radical scavenging activity	802:840	There was 1-fold higher xylan to XOS conversion and OAAH-hydrolysate had higher DPPH radical scavenging activity than AH.
34280853	6	10	dep	suggest	1013:1019	arg1	option					1059:1064	an effective pretreatment option	1033:1064	an effective pretreatment option that can further be integrated with downstream processing for concentration and purification of XOS	1033:1164	Results of the study therefore suggest OAAH can be an effective pretreatment option that can further be integrated with downstream processing for concentration and purification of XOS.
34280853	0	11	theme	compounds	117:125	arg1	generation					93:102	low generation	89:102	low generation of inhibitor compounds	89:125	Ozone assisted autohydrolysis of wheat bran enhances xylooligosaccharide production with low generation of inhibitor compounds: A comparative study.
34280853	1	12	from	bran	286:289	arg1	generation					235:244	enhanced generation	226:244	enhanced generation of xylooligosaccharide (XOS) from wheat bran	226:289	In the present study, ozone assisted autohydrolysis (OAAH) was evaluated for enhanced generation of xylooligosaccharide (XOS) from wheat bran.
34280853	1	13	theme	ozone	171:175	arg1	OAAH					202:205	OAAH	202:205	OAAH	202:205	In the present study, ozone assisted autohydrolysis (OAAH) was evaluated for enhanced generation of xylooligosaccharide (XOS) from wheat bran.
34280853	1	13	theme	ozone	171:175	arg1	autohydrolysis					186:199	ozone assisted autohydrolysis	171:199	ozone assisted autohydrolysis (OAAH)	171:206	In the present study, ozone assisted autohydrolysis (OAAH) was evaluated for enhanced generation of xylooligosaccharide (XOS) from wheat bran.
34280853	0	14	theme	assisted	6:13	arg1	autohydrolysis					15:28	Ozone assisted autohydrolysis	0:28	Ozone assisted autohydrolysis of wheat bran	0:42	Ozone assisted autohydrolysis of wheat bran enhances xylooligosaccharide production with low generation of inhibitor compounds: A comparative study.
34280853	2	15	from	110 °C	389:394	arg1	%					370:370	8.9%	367:370	8.9% (w/w biomass) at 110 °C	367:394	The total XOS yield with optimum ozone dose of 3% (OAAH-3) was found to be 8.9% (w/w biomass) at 110 °C in comparison to 7.96% at 170 °C by autohydrolysis (AH) alone.
34280853	2	15	from	110 °C	389:394	arg1	biomass					377:383	w/w biomass	373:383	w/w biomass	373:383	The total XOS yield with optimum ozone dose of 3% (OAAH-3) was found to be 8.9% (w/w biomass) at 110 °C in comparison to 7.96% at 170 °C by autohydrolysis (AH) alone.
34280853	2	15	from	110 °C	389:394	arg1	yield					306:310	The total XOS yield	292:310	The total XOS yield with optimum ozone dose of 3% (OAAH-3)	292:349	The total XOS yield with optimum ozone dose of 3% (OAAH-3) was found to be 8.9% (w/w biomass) at 110 °C in comparison to 7.96% at 170 °C by autohydrolysis (AH) alone.
34280853	6	16	theme	downstream	1102:1111	arg1	processing					1113:1122	downstream processing	1102:1122	downstream processing for concentration and purification of XOS	1102:1164	Results of the study therefore suggest OAAH can be an effective pretreatment option that can further be integrated with downstream processing for concentration and purification of XOS.
34280853	2	17	theme	XOS	302:304	arg1	yield					306:310	The total XOS yield	292:310	The total XOS yield with optimum ozone dose of 3% (OAAH-3)	292:349	The total XOS yield with optimum ozone dose of 3% (OAAH-3) was found to be 8.9% (w/w biomass) at 110 °C in comparison to 7.96% at 170 °C by autohydrolysis (AH) alone.
34280853	2	17	theme	XOS	302:304	arg1	%					370:370	8.9%	367:370	8.9% (w/w biomass) at 110 °C	367:394	The total XOS yield with optimum ozone dose of 3% (OAAH-3) was found to be 8.9% (w/w biomass) at 110 °C in comparison to 7.96% at 170 °C by autohydrolysis (AH) alone.
34280853	1	18	theme	assisted	177:184	arg1	OAAH					202:205	OAAH	202:205	OAAH	202:205	In the present study, ozone assisted autohydrolysis (OAAH) was evaluated for enhanced generation of xylooligosaccharide (XOS) from wheat bran.
34280853	1	18	theme	assisted	177:184	arg1	autohydrolysis					186:199	ozone assisted autohydrolysis	171:199	ozone assisted autohydrolysis (OAAH)	171:206	In the present study, ozone assisted autohydrolysis (OAAH) was evaluated for enhanced generation of xylooligosaccharide (XOS) from wheat bran.
34280853	0	19	theme	Ozone	0:4	arg1	autohydrolysis					15:28	Ozone assisted autohydrolysis	0:28	Ozone assisted autohydrolysis of wheat bran	0:42	Ozone assisted autohydrolysis of wheat bran enhances xylooligosaccharide production with low generation of inhibitor compounds: A comparative study.
34280853	3	20	dep	products	577:584	arg1	furfural					593:600	furfural	593:600	degradation products namely furfural (2.78-fold)	565:612	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	20	dep	products	577:584	arg1	2.78-fold					603:611	2.78-fold	603:611	2.78-fold	603:611	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	2	21	theme	total	296:300	arg1	yield					306:310	The total XOS yield	292:310	The total XOS yield with optimum ozone dose of 3% (OAAH-3)	292:349	The total XOS yield with optimum ozone dose of 3% (OAAH-3) was found to be 8.9% (w/w biomass) at 110 °C in comparison to 7.96% at 170 °C by autohydrolysis (AH) alone.
34280853	2	21	theme	total	296:300	arg1	%					370:370	8.9%	367:370	8.9% (w/w biomass) at 110 °C	367:394	The total XOS yield with optimum ozone dose of 3% (OAAH-3) was found to be 8.9% (w/w biomass) at 110 °C in comparison to 7.96% at 170 °C by autohydrolysis (AH) alone.
34280853	0	22	theme	comparative	130:140	arg1	study					142:146	A comparative study	128:146	A comparative study	128:146	Ozone assisted autohydrolysis of wheat bran enhances xylooligosaccharide production with low generation of inhibitor compounds: A comparative study.
34280853	6	23	theme	study	997:1001	arg1	Results					982:988	Results	982:988	Results of the study	982:1001	Results of the study therefore suggest OAAH can be an effective pretreatment option that can further be integrated with downstream processing for concentration and purification of XOS.
34280853	5	24	from	enhancement	877:887	arg1	production					896:905	XOS production	892:905	XOS production	892:905	PCA plots indicated clear enhancement in XOS production and lower generation of inhibitors with decrease in treatment temperature.
34280853	5	25	from	decrease	947:954	arg1	temperature					969:979	treatment temperature	959:979	treatment temperature	959:979	PCA plots indicated clear enhancement in XOS production and lower generation of inhibitors with decrease in treatment temperature.
34280853	1	26	theme	wheat	280:284	arg1	bran					286:289	wheat bran	280:289	wheat bran	280:289	In the present study, ozone assisted autohydrolysis (OAAH) was evaluated for enhanced generation of xylooligosaccharide (XOS) from wheat bran.
34280853	5	27	theme	lower	911:915	arg1	generation					917:926	lower generation	911:926	lower generation of inhibitors	911:940	PCA plots indicated clear enhancement in XOS production and lower generation of inhibitors with decrease in treatment temperature.
34280853	0	28	theme	bran	39:42	arg1	autohydrolysis					15:28	Ozone assisted autohydrolysis	0:28	Ozone assisted autohydrolysis of wheat bran	0:42	Ozone assisted autohydrolysis of wheat bran enhances xylooligosaccharide production with low generation of inhibitor compounds: A comparative study.
34280853	2	29	with	yield	306:310	arg1	dose					331:334	optimum ozone dose	317:334	optimum ozone dose of 3% (OAAH-3)	317:349	The total XOS yield with optimum ozone dose of 3% (OAAH-3) was found to be 8.9% (w/w biomass) at 110 °C in comparison to 7.96% at 170 °C by autohydrolysis (AH) alone.
34280853	3	30	theme	significant	482:492	arg1	difference					494:503	no significant difference	479:503	no significant difference	479:503	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	6	31	theme	effective	1036:1044	arg1	option					1059:1064	an effective pretreatment option	1033:1064	an effective pretreatment option that can further be integrated with downstream processing for concentration and purification of XOS	1033:1164	Results of the study therefore suggest OAAH can be an effective pretreatment option that can further be integrated with downstream processing for concentration and purification of XOS.
34280853	0	32	theme	wheat	33:37	arg1	bran					39:42	wheat bran	33:42	wheat bran	33:42	Ozone assisted autohydrolysis of wheat bran enhances xylooligosaccharide production with low generation of inhibitor compounds: A comparative study.
34280853	4	33	theme	XOS	762:764	arg1	conversion					766:775	XOS conversion	762:775	XOS conversion	762:775	There was 1-fold higher xylan to XOS conversion and OAAH-hydrolysate had higher DPPH radical scavenging activity than AH.
34280853	4	34	contain	had	798:800	arg2	activity					833:840	higher DPPH radical scavenging activity	802:840	higher DPPH radical scavenging activity	802:840	There was 1-fold higher xylan to XOS conversion and OAAH-hydrolysate had higher DPPH radical scavenging activity than AH.
34280853	4	34	contain	had	798:800	arg1	OAAH-hydrolysate					781:796	OAAH-hydrolysate	781:796	OAAH-hydrolysate	781:796	There was 1-fold higher xylan to XOS conversion and OAAH-hydrolysate had higher DPPH radical scavenging activity than AH.
34280853	5	35	from	generation	917:926	arg1	production					896:905	XOS production	892:905	XOS production	892:905	PCA plots indicated clear enhancement in XOS production and lower generation of inhibitors with decrease in treatment temperature.
34280853	0	36	theme	xylooligosaccharide	53:71	arg1	production					73:82	xylooligosaccharide production	53:82	xylooligosaccharide production	53:82	Ozone assisted autohydrolysis of wheat bran enhances xylooligosaccharide production with low generation of inhibitor compounds: A comparative study.
34280853	4	37	theme	DPPH	809:812	arg1	activity					833:840	higher DPPH radical scavenging activity	802:840	higher DPPH radical scavenging activity	802:840	There was 1-fold higher xylan to XOS conversion and OAAH-hydrolysate had higher DPPH radical scavenging activity than AH.
34280853	5	38	theme	clear	871:875	arg1	enhancement					877:887	clear enhancement	871:887	clear enhancement in XOS production	871:905	PCA plots indicated clear enhancement in XOS production and lower generation of inhibitors with decrease in treatment temperature.
34280853	2	39	theme	ozone	325:329	arg1	dose					331:334	optimum ozone dose	317:334	optimum ozone dose of 3% (OAAH-3)	317:349	The total XOS yield with optimum ozone dose of 3% (OAAH-3) was found to be 8.9% (w/w biomass) at 110 °C in comparison to 7.96% at 170 °C by autohydrolysis (AH) alone.
34280853	2	40	from	170 °C	422:427	arg1	%					417:417	7.96%	413:417	7.96% at 170 °C by autohydrolysis (AH) alone	413:456	The total XOS yield with optimum ozone dose of 3% (OAAH-3) was found to be 8.9% (w/w biomass) at 110 °C in comparison to 7.96% at 170 °C by autohydrolysis (AH) alone.
34280853	5	41	theme	XOS	892:894	arg1	production					896:905	XOS production	892:905	XOS production	892:905	PCA plots indicated clear enhancement in XOS production and lower generation of inhibitors with decrease in treatment temperature.
34280853	2	42	theme	optimum	317:323	arg1	dose					331:334	optimum ozone dose	317:334	optimum ozone dose of 3% (OAAH-3)	317:349	The total XOS yield with optimum ozone dose of 3% (OAAH-3) was found to be 8.9% (w/w biomass) at 110 °C in comparison to 7.96% at 170 °C by autohydrolysis (AH) alone.
34280853	5	43	theme	PCA	851:853	arg1	plots					855:859	PCA plots	851:859	PCA plots	851:859	PCA plots indicated clear enhancement in XOS production and lower generation of inhibitors with decrease in treatment temperature.
34280853	4	44	theme	higher	746:751	arg1	xylan					753:757	1-fold higher xylan	739:757	1-fold higher xylan to XOS conversion	739:775	There was 1-fold higher xylan to XOS conversion and OAAH-hydrolysate had higher DPPH radical scavenging activity than AH.
34280853	3	45	theme	degradation	565:575	arg1	acid					660:663	acetic acid	653:663	acetic acid (1.06-fold)	653:675	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	45	theme	degradation	565:575	arg1	products					577:584	degradation products	565:584	degradation products namely furfural (2.78-fold)	565:612	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	45	theme	degradation	565:575	arg1	acrylamide					632:641	acrylamide	632:641	acrylamide (nil)	632:647	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	45	theme	degradation	565:575	arg1	HMF					615:617	HMF	615:617	HMF (3.15-fold)	615:629	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	6	46	theme	XOS	1162:1164	arg1	purification					1146:1157	purification	1146:1157	purification	1146:1157	Results of the study therefore suggest OAAH can be an effective pretreatment option that can further be integrated with downstream processing for concentration and purification of XOS.
34280853	6	46	theme	XOS	1162:1164	arg1	concentration					1128:1140	concentration	1128:1140	concentration	1128:1140	Results of the study therefore suggest OAAH can be an effective pretreatment option that can further be integrated with downstream processing for concentration and purification of XOS.
34280853	3	47	theme	significant	541:551	arg1	decrease					553:560	significant decrease	541:560	significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold),	541:676	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	47	theme	significant	541:551	arg1	option					721:726	a pretreatment option	706:726	a pretreatment option	706:726	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	4	48	theme	radical	814:820	arg1	activity					833:840	higher DPPH radical scavenging activity	802:840	higher DPPH radical scavenging activity	802:840	There was 1-fold higher xylan to XOS conversion and OAAH-hydrolysate had higher DPPH radical scavenging activity than AH.
34280853	6	49	theme	pretreatment	1046:1057	arg1	option					1059:1064	an effective pretreatment option	1033:1064	an effective pretreatment option that can further be integrated with downstream processing for concentration and purification of XOS	1033:1164	Results of the study therefore suggest OAAH can be an effective pretreatment option that can further be integrated with downstream processing for concentration and purification of XOS.
34280853	2	50	theme	%	340:340	arg1	dose					331:334	optimum ozone dose	317:334	optimum ozone dose of 3% (OAAH-3)	317:349	The total XOS yield with optimum ozone dose of 3% (OAAH-3) was found to be 8.9% (w/w biomass) at 110 °C in comparison to 7.96% at 170 °C by autohydrolysis (AH) alone.
34280853	1	51	theme	enhanced	226:233	arg1	generation					235:244	enhanced generation	226:244	enhanced generation of xylooligosaccharide (XOS) from wheat bran	226:289	In the present study, ozone assisted autohydrolysis (OAAH) was evaluated for enhanced generation of xylooligosaccharide (XOS) from wheat bran.
34280853	3	52	from	decrease	553:560	arg1	acid					660:663	acetic acid	653:663	acetic acid (1.06-fold)	653:675	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	52	from	decrease	553:560	arg1	products					577:584	degradation products	565:584	degradation products namely furfural (2.78-fold)	565:612	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	52	from	decrease	553:560	arg1	acrylamide					632:641	acrylamide	632:641	acrylamide (nil)	632:647	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	52	from	decrease	553:560	arg1	HMF					615:617	HMF	615:617	HMF (3.15-fold)	615:629	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	53	theme	oligomeric	508:517	arg1	DP					532:533	DP 2-6	532:537	DP 2-6	532:537	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	53	theme	oligomeric	508:517	arg1	composition					519:529	oligomeric composition	508:529	oligomeric composition (DP 2-6)	508:538	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	54	theme	acetic	653:658	arg1	acid					660:663	acetic acid	653:663	acetic acid (1.06-fold)	653:675	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	54	theme	acetic	653:658	arg1	products					577:584	degradation products	565:584	degradation products namely furfural (2.78-fold)	565:612	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34280853	3	54	theme	acetic	653:658	arg1	1.06-fold					666:674	1.06-fold	666:674	1.06-fold	666:674	Although, there was no significant difference in oligomeric composition (DP 2-6), significant decrease in degradation products namely furfural (2.78-fold), HMF (3.15-fold), acrylamide (nil) and acetic acid (1.06-fold), was observed with OAAH-3 as a pretreatment option.
34027656	5	0	theme	fibrin	774:779	arg1	structure					789:797	final fibrin network structure	768:797	final fibrin network structure	768:797	CNCs induced a significant modification of the initial fibrin fibrillogenesis and final fibrin network structure, and storage moduli of all nanocomposites were larger than those of pure fibrin hydrogels.
34027656	6	1	theme	optimal	900:906	arg1	conditions					908:917	optimal conditions	900:917	optimal conditions	900:917	Moreover, optimal conditions were found that promoted muscle cell differentiation and formation of long myotubes.
34027656	5	2	theme	network	781:787	arg1	structure					789:797	final fibrin network structure	768:797	final fibrin network structure	768:797	CNCs induced a significant modification of the initial fibrin fibrillogenesis and final fibrin network structure, and storage moduli of all nanocomposites were larger than those of pure fibrin hydrogels.
34027656	2	3	theme	mechanical	358:367	arg1	stability					369:377	improved mechanical stability	349:377	improved mechanical stability	349:377	Here, we evaluated the possibility to combine them with fibrinogen and obtain fibrin hydrogels with improved mechanical stability as potential cellular scaffolds.
34027656	7	4	theme	new	1131:1133	arg1	perspectives					1135:1146	new perspectives	1131:1146	new perspectives for the design of injectable fibrin-based formulations	1131:1201	These results provide original insights into the interactions of CNCs with proteins with key physiological functions and offer new perspectives for the design of injectable fibrin-based formulations.
34027656	1	5	theme	Cellulose	82:90	arg1	fillers					140:146	fillers	140:146	fillers	140:146	Cellulose nanocrystals (CNCs) have been widely studied as fillers to form reinforced nanocomposites with a wide range of applications, including the biomedical field.
34027656	1	5	theme	Cellulose	82:90	arg1	CNCs					106:109	CNCs	106:109	CNCs	106:109	Cellulose nanocrystals (CNCs) have been widely studied as fillers to form reinforced nanocomposites with a wide range of applications, including the biomedical field.
34027656	1	5	theme	Cellulose	82:90	arg1	nanocrystals					92:103	Cellulose nanocrystals	82:103	Cellulose nanocrystals (CNCs)	82:110	Cellulose nanocrystals (CNCs) have been widely studied as fillers to form reinforced nanocomposites with a wide range of applications, including the biomedical field.
34027656	5	6	theme	initial	733:739	arg1	fibrillogenesis					748:762	the initial fibrin fibrillogenesis	729:762	the initial fibrin fibrillogenesis	729:762	CNCs induced a significant modification of the initial fibrin fibrillogenesis and final fibrin network structure, and storage moduli of all nanocomposites were larger than those of pure fibrin hydrogels.
34027656	5	7	theme	significant	701:711	arg1	modification					713:724	a significant modification	699:724	a significant modification of the initial fibrin fibrillogenesis	699:762	CNCs induced a significant modification of the initial fibrin fibrillogenesis and final fibrin network structure, and storage moduli of all nanocomposites were larger than those of pure fibrin hydrogels.
34027656	6	8	theme	myotubes	994:1001	arg1	formation					976:984	formation	976:984	formation of long myotubes	976:1001	Moreover, optimal conditions were found that promoted muscle cell differentiation and formation of long myotubes.
34027656	6	8	theme	myotubes	994:1001	arg1	differentiation					956:970	muscle cell differentiation	944:970	muscle cell differentiation	944:970	Moreover, optimal conditions were found that promoted muscle cell differentiation and formation of long myotubes.
34027656	5	9	theme	fibrin	741:746	arg1	fibrillogenesis					748:762	the initial fibrin fibrillogenesis	729:762	the initial fibrin fibrillogenesis	729:762	CNCs induced a significant modification of the initial fibrin fibrillogenesis and final fibrin network structure, and storage moduli of all nanocomposites were larger than those of pure fibrin hydrogels.
34027656	7	10	with	proteins	1079:1086	arg1	functions					1111:1119	key physiological functions	1093:1119	key physiological functions	1093:1119	These results provide original insights into the interactions of CNCs with proteins with key physiological functions and offer new perspectives for the design of injectable fibrin-based formulations.
34027656	5	11	theme	fibrin	872:877	arg1	hydrogels					879:887	pure fibrin hydrogels	867:887	pure fibrin hydrogels	867:887	CNCs induced a significant modification of the initial fibrin fibrillogenesis and final fibrin network structure, and storage moduli of all nanocomposites were larger than those of pure fibrin hydrogels.
34027656	5	12	theme	fibrillogenesis	748:762	arg1	structure					789:797	final fibrin network structure	768:797	final fibrin network structure	768:797	CNCs induced a significant modification of the initial fibrin fibrillogenesis and final fibrin network structure, and storage moduli of all nanocomposites were larger than those of pure fibrin hydrogels.
34027656	5	12	theme	fibrillogenesis	748:762	arg1	modification					713:724	a significant modification	699:724	a significant modification of the initial fibrin fibrillogenesis	699:762	CNCs induced a significant modification of the initial fibrin fibrillogenesis and final fibrin network structure, and storage moduli of all nanocomposites were larger than those of pure fibrin hydrogels.
34027656	7	13	theme	injectable	1166:1175	arg1	formulations					1190:1201	injectable fibrin-based formulations	1166:1201	injectable fibrin-based formulations	1166:1201	These results provide original insights into the interactions of CNCs with proteins with key physiological functions and offer new perspectives for the design of injectable fibrin-based formulations.
34027656	7	14	theme	key	1093:1095	arg1	functions					1111:1119	key physiological functions	1093:1119	key physiological functions	1093:1119	These results provide original insights into the interactions of CNCs with proteins with key physiological functions and offer new perspectives for the design of injectable fibrin-based formulations.
34027656	4	15	dep	%	683:683	arg1	wt					680:681	wt	680:681	wt	680:681	Composite hydrogels could be prepared from concentrated fibrinogen solutions and nanocrystals in amounts up to 0.3 wt %.
34027656	1	16	theme	wide	189:192	arg1	range					194:198	a wide range	187:198	a wide range of applications, including the biomedical field	187:246	Cellulose nanocrystals (CNCs) have been widely studied as fillers to form reinforced nanocomposites with a wide range of applications, including the biomedical field.
34027656	1	16	theme	wide	189:192	arg1	field					242:246	the biomedical field	227:246	the biomedical field	227:246	Cellulose nanocrystals (CNCs) have been widely studied as fillers to form reinforced nanocomposites with a wide range of applications, including the biomedical field.
34027656	0	17	theme	Nanocrystal-Fibrin	10:27	arg1	Hydrogels					43:51	Cellulose Nanocrystal-Fibrin Nanocomposite Hydrogels	0:51	Cellulose Nanocrystal-Fibrin Nanocomposite Hydrogels	0:51	Cellulose Nanocrystal-Fibrin Nanocomposite Hydrogels Promoting Myotube Formation.
34027656	7	18	theme	physiological	1097:1109	arg1	functions					1111:1119	key physiological functions	1093:1119	key physiological functions	1093:1119	These results provide original insights into the interactions of CNCs with proteins with key physiological functions and offer new perspectives for the design of injectable fibrin-based formulations.
34027656	3	19	theme	neutral	439:445	arg1	pH					447:448	a neutral pH	437:448	a neutral pH	437:448	In diluted conditions at a neutral pH, it was evidenced that fibrinogen could adsorb on CNCs in a two-step process, favoring their alignment under flow.
34027656	0	20	theme	Cellulose	0:8	arg1	Hydrogels					43:51	Cellulose Nanocrystal-Fibrin Nanocomposite Hydrogels	0:51	Cellulose Nanocrystal-Fibrin Nanocomposite Hydrogels	0:51	Cellulose Nanocrystal-Fibrin Nanocomposite Hydrogels Promoting Myotube Formation.
34027656	6	21	theme	long	989:992	arg1	myotubes					994:1001	long myotubes	989:1001	long myotubes	989:1001	Moreover, optimal conditions were found that promoted muscle cell differentiation and formation of long myotubes.
34027656	4	22	theme	0.3	676:678	arg1	wt					680:681	wt	680:681	wt	680:681	Composite hydrogels could be prepared from concentrated fibrinogen solutions and nanocrystals in amounts up to 0.3 wt %.
34027656	7	23	theme	formulations	1190:1201	arg1	design					1156:1161	the design	1152:1161	the design of injectable fibrin-based formulations	1152:1201	These results provide original insights into the interactions of CNCs with proteins with key physiological functions and offer new perspectives for the design of injectable fibrin-based formulations.
34027656	3	24	from	CNCs	500:503	arg1	process					519:525	a two-step process	508:525	a two-step process	508:525	In diluted conditions at a neutral pH, it was evidenced that fibrinogen could adsorb on CNCs in a two-step process, favoring their alignment under flow.
34027656	1	25	theme	applications	203:214	arg1	range					194:198	a wide range	187:198	a wide range of applications, including the biomedical field	187:246	Cellulose nanocrystals (CNCs) have been widely studied as fillers to form reinforced nanocomposites with a wide range of applications, including the biomedical field.
34027656	1	25	theme	applications	203:214	arg1	field					242:246	the biomedical field	227:246	the biomedical field	227:246	Cellulose nanocrystals (CNCs) have been widely studied as fillers to form reinforced nanocomposites with a wide range of applications, including the biomedical field.
34027656	0	26	theme	Nanocomposite	29:41	arg1	Hydrogels					43:51	Cellulose Nanocrystal-Fibrin Nanocomposite Hydrogels	0:51	Cellulose Nanocrystal-Fibrin Nanocomposite Hydrogels	0:51	Cellulose Nanocrystal-Fibrin Nanocomposite Hydrogels Promoting Myotube Formation.
34027656	4	27	theme	Composite	565:573	arg1	hydrogels					575:583	Composite hydrogels	565:583	Composite hydrogels	565:583	Composite hydrogels could be prepared from concentrated fibrinogen solutions and nanocrystals in amounts up to 0.3 wt %.
34027656	4	28	theme	concentrated	608:619	arg1	solutions					632:640	concentrated fibrinogen solutions	608:640	concentrated fibrinogen solutions	608:640	Composite hydrogels could be prepared from concentrated fibrinogen solutions and nanocrystals in amounts up to 0.3 wt %.
34027656	2	29	with	hydrogels	334:342	arg1	stability					369:377	improved mechanical stability	349:377	improved mechanical stability	349:377	Here, we evaluated the possibility to combine them with fibrinogen and obtain fibrin hydrogels with improved mechanical stability as potential cellular scaffolds.
34027656	4	30	from	nanocrystals	646:657	arg1	amounts					662:668	amounts	662:668	amounts up to 0.3 wt %	662:683	Composite hydrogels could be prepared from concentrated fibrinogen solutions and nanocrystals in amounts up to 0.3 wt %.
34027656	2	31	theme	potential	382:390	arg1	scaffolds					401:409	potential cellular scaffolds	382:409	potential cellular scaffolds	382:409	Here, we evaluated the possibility to combine them with fibrinogen and obtain fibrin hydrogels with improved mechanical stability as potential cellular scaffolds.
34027656	2	31	theme	potential	382:390	arg1	hydrogels					334:342	fibrin hydrogels	327:342	fibrin hydrogels with improved mechanical stability	327:377	Here, we evaluated the possibility to combine them with fibrinogen and obtain fibrin hydrogels with improved mechanical stability as potential cellular scaffolds.
34027656	0	32	theme	Myotube	63:69	arg1	Formation					71:79	Myotube Formation	63:79	Myotube Formation	63:79	Cellulose Nanocrystal-Fibrin Nanocomposite Hydrogels Promoting Myotube Formation.
34027656	4	33	dep	amounts	662:668	arg1	%					683:683	%	683:683	%	683:683	Composite hydrogels could be prepared from concentrated fibrinogen solutions and nanocrystals in amounts up to 0.3 wt %.
34027656	2	34	theme	cellular	392:399	arg1	scaffolds					401:409	potential cellular scaffolds	382:409	potential cellular scaffolds	382:409	Here, we evaluated the possibility to combine them with fibrinogen and obtain fibrin hydrogels with improved mechanical stability as potential cellular scaffolds.
34027656	2	34	theme	cellular	392:399	arg1	hydrogels					334:342	fibrin hydrogels	327:342	fibrin hydrogels with improved mechanical stability	327:377	Here, we evaluated the possibility to combine them with fibrinogen and obtain fibrin hydrogels with improved mechanical stability as potential cellular scaffolds.
34027656	7	35	theme	fibrin-based	1177:1188	arg1	formulations					1190:1201	injectable fibrin-based formulations	1166:1201	injectable fibrin-based formulations	1166:1201	These results provide original insights into the interactions of CNCs with proteins with key physiological functions and offer new perspectives for the design of injectable fibrin-based formulations.
34027656	3	36	theme	diluted	415:421	arg1	conditions					423:432	diluted conditions	415:432	diluted conditions at a neutral pH	415:448	In diluted conditions at a neutral pH, it was evidenced that fibrinogen could adsorb on CNCs in a two-step process, favoring their alignment under flow.
34027656	6	37	theme	cell	951:954	arg1	differentiation					956:970	muscle cell differentiation	944:970	muscle cell differentiation	944:970	Moreover, optimal conditions were found that promoted muscle cell differentiation and formation of long myotubes.
34027656	2	38	theme	improved	349:356	arg1	stability					369:377	improved mechanical stability	349:377	improved mechanical stability	349:377	Here, we evaluated the possibility to combine them with fibrinogen and obtain fibrin hydrogels with improved mechanical stability as potential cellular scaffolds.
34027656	5	39	theme	storage	804:810	arg1	moduli					812:817	storage moduli	804:817	storage moduli of all nanocomposites	804:839	CNCs induced a significant modification of the initial fibrin fibrillogenesis and final fibrin network structure, and storage moduli of all nanocomposites were larger than those of pure fibrin hydrogels.
34027656	6	40	theme	muscle	944:949	arg1	differentiation					956:970	muscle cell differentiation	944:970	muscle cell differentiation	944:970	Moreover, optimal conditions were found that promoted muscle cell differentiation and formation of long myotubes.
34027656	7	41	theme	CNCs	1069:1072	arg1	interactions					1053:1064	the interactions	1049:1064	the interactions of CNCs with proteins with key physiological functions	1049:1119	These results provide original insights into the interactions of CNCs with proteins with key physiological functions and offer new perspectives for the design of injectable fibrin-based formulations.
34027656	4	42	dep	wt	680:681	arg1	to					673:674	to	673:674	to	673:674	Composite hydrogels could be prepared from concentrated fibrinogen solutions and nanocrystals in amounts up to 0.3 wt %.
34027656	7	43	theme	original	1026:1033	arg1	insights					1035:1042	original insights	1026:1042	original insights into the interactions of CNCs with proteins with key physiological functions	1026:1119	These results provide original insights into the interactions of CNCs with proteins with key physiological functions and offer new perspectives for the design of injectable fibrin-based formulations.
34027656	1	44	theme	biomedical	231:240	arg1	field					242:246	the biomedical field	227:246	the biomedical field	227:246	Cellulose nanocrystals (CNCs) have been widely studied as fillers to form reinforced nanocomposites with a wide range of applications, including the biomedical field.
34027656	7	45	with	CNCs	1069:1072	arg1	proteins					1079:1086	proteins	1079:1086	proteins with key physiological functions	1079:1119	These results provide original insights into the interactions of CNCs with proteins with key physiological functions and offer new perspectives for the design of injectable fibrin-based formulations.
34027656	2	46	theme	fibrin	327:332	arg1	hydrogels					334:342	fibrin hydrogels	327:342	fibrin hydrogels with improved mechanical stability	327:377	Here, we evaluated the possibility to combine them with fibrinogen and obtain fibrin hydrogels with improved mechanical stability as potential cellular scaffolds.
34027656	2	46	theme	fibrin	327:332	arg1	scaffolds					401:409	potential cellular scaffolds	382:409	potential cellular scaffolds	382:409	Here, we evaluated the possibility to combine them with fibrinogen and obtain fibrin hydrogels with improved mechanical stability as potential cellular scaffolds.
34027656	4	47	from	solutions	632:640	arg1	amounts					662:668	amounts	662:668	amounts up to 0.3 wt %	662:683	Composite hydrogels could be prepared from concentrated fibrinogen solutions and nanocrystals in amounts up to 0.3 wt %.
34027656	3	48	from	pH	447:448	arg1	conditions					423:432	diluted conditions	415:432	diluted conditions at a neutral pH	415:448	In diluted conditions at a neutral pH, it was evidenced that fibrinogen could adsorb on CNCs in a two-step process, favoring their alignment under flow.
34027656	3	49	theme	two-step	510:517	arg1	process					519:525	a two-step process	508:525	a two-step process	508:525	In diluted conditions at a neutral pH, it was evidenced that fibrinogen could adsorb on CNCs in a two-step process, favoring their alignment under flow.
34027656	5	50	theme	pure	867:870	arg1	hydrogels					879:887	pure fibrin hydrogels	867:887	pure fibrin hydrogels	867:887	CNCs induced a significant modification of the initial fibrin fibrillogenesis and final fibrin network structure, and storage moduli of all nanocomposites were larger than those of pure fibrin hydrogels.
34027656	5	51	theme	final	768:772	arg1	structure					789:797	final fibrin network structure	768:797	final fibrin network structure	768:797	CNCs induced a significant modification of the initial fibrin fibrillogenesis and final fibrin network structure, and storage moduli of all nanocomposites were larger than those of pure fibrin hydrogels.
34027656	5	52	theme	nanocomposites	826:839	arg1	moduli					812:817	storage moduli	804:817	storage moduli of all nanocomposites	804:839	CNCs induced a significant modification of the initial fibrin fibrillogenesis and final fibrin network structure, and storage moduli of all nanocomposites were larger than those of pure fibrin hydrogels.
34027656	1	53	theme	reinforced	156:165	arg1	nanocomposites					167:180	reinforced nanocomposites	156:180	reinforced nanocomposites	156:180	Cellulose nanocrystals (CNCs) have been widely studied as fillers to form reinforced nanocomposites with a wide range of applications, including the biomedical field.
34027656	4	54	theme	fibrinogen	621:630	arg1	solutions					632:640	concentrated fibrinogen solutions	608:640	concentrated fibrinogen solutions	608:640	Composite hydrogels could be prepared from concentrated fibrinogen solutions and nanocrystals in amounts up to 0.3 wt %.
32574729	0	0	theme	skeleton	82:89	arg1	growth					54:59	the in-situ growth	42:59	the in-situ growth of zeolite imidazole skeleton on regenerated cellulose aerogel for efficient removal of tetracycline	42:160	Polyaniline as interface layers promoting the in-situ growth of zeolite imidazole skeleton on regenerated cellulose aerogel for efficient removal of tetracycline.
32574729	3	1	from	MOFs	433:436	arg1	form					452:455	the powder form	441:455	the powder form	441:455	To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA).
32574729	10	2	dep	applications	1565:1576	arg1	out					1555:1557	out	1555:1557	out	1555:1557	This strategy may provide an effective and versatile pathway to increase MOF loading mass on aerogel and sequentially branch out their applications in pollutant treatment fields.
32574729	3	3	theme	ZIF-67	507:512	arg1	strategy					480:487	a strategy	478:487	a strategy of in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA)	478:581	To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA).
32574729	10	4	from	applications	1565:1576	arg1	fields					1601:1606	pollutant treatment fields	1581:1606	pollutant treatment fields	1581:1606	This strategy may provide an effective and versatile pathway to increase MOF loading mass on aerogel and sequentially branch out their applications in pollutant treatment fields.
32574729	0	5	theme	imidazole	72:80	arg1	skeleton					82:89	zeolite imidazole skeleton	64:89	zeolite imidazole skeleton	64:89	Polyaniline as interface layers promoting the in-situ growth of zeolite imidazole skeleton on regenerated cellulose aerogel for efficient removal of tetracycline.
32574729	0	6	theme	regenerated	94:104	arg1	aerogel					116:122	regenerated cellulose aerogel	94:122	regenerated cellulose aerogel for efficient removal of tetracycline	94:160	Polyaniline as interface layers promoting the in-situ growth of zeolite imidazole skeleton on regenerated cellulose aerogel for efficient removal of tetracycline.
32574729	7	7	theme	loading	946:952	arg1	ratios					959:964	The loading mass ratios	942:964	The loading mass ratios of ZIF-67 on RCA and PANI/RCA	942:994	The loading mass ratios of ZIF-67 on RCA and PANI/RCA were 25.39% and 42.38%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA.
32574729	7	7	theme	loading	946:952	arg1	%					1006:1006	25.39%	1001:1006	25.39%	1001:1006	The loading mass ratios of ZIF-67 on RCA and PANI/RCA were 25.39% and 42.38%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA.
32574729	9	8	theme	removal	1381:1387	arg1	efficiency					1389:1398	the removal efficiency	1377:1398	the removal efficiency toward TC	1377:1408	After six cycles of adsorption-desorption, the removal efficiency toward TC was still over 94%.
32574729	0	9	from	growth	54:59	arg1	aerogel					116:122	regenerated cellulose aerogel	94:122	regenerated cellulose aerogel for efficient removal of tetracycline	94:160	Polyaniline as interface layers promoting the in-situ growth of zeolite imidazole skeleton on regenerated cellulose aerogel for efficient removal of tetracycline.
32574729	6	10	theme	ZIF-67	783:788	arg1	nanocrystals					790:801	ZIF-67 nanocrystals	783:801	ZIF-67 nanocrystals	783:801	Finally, ZIF-67 nanocrystals were in-situ growth on the surface of the PANI coated regenerated cellulose aerogel to synthesise the composite adsorbent ZIF-67/PANI/RCA.
32574729	3	11	theme	regenerated	547:557	arg1	aerogel					569:575	regenerated cellulose aerogel	547:575	regenerated cellulose aerogel (RCA)	547:581	To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA).
32574729	3	11	theme	regenerated	547:557	arg1	RCA					578:580	RCA	578:580	RCA	578:580	To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA).
32574729	6	12	theme	cellulose	869:877	arg1	aerogel					879:885	regenerated cellulose aerogel	857:885	regenerated cellulose aerogel	857:885	Finally, ZIF-67 nanocrystals were in-situ growth on the surface of the PANI coated regenerated cellulose aerogel to synthesise the composite adsorbent ZIF-67/PANI/RCA.
32574729	4	13	theme	chemical	611:618	arg1	cross-linking					620:632	chemical cross-linking	611:632	chemical cross-linking	611:632	First, RCA was obtained by chemical cross-linking and physical cross-linking method.
32574729	8	14	theme	good	1310:1313	arg1	ability					1325:1331	good recycling ability	1310:1331	good recycling ability	1310:1331	The obtained composite adsorbent (ZIF-67/PANI/RCA) was applied for the adsorption of tetracycline (TC) with high adsorption capacity (409.55 mg·g-1) and good recycling ability.
32574729	1	15	theme	organic	193:199	arg1	pollutants					201:210	newly emerging organic pollutants	178:210	newly emerging organic pollutants	178:210	Antibiotics as newly emerging organic pollutants are arousing more and more serious environmental issues.
32574729	0	16	theme	cellulose	106:114	arg1	aerogel					116:122	regenerated cellulose aerogel	94:122	regenerated cellulose aerogel for efficient removal of tetracycline	94:160	Polyaniline as interface layers promoting the in-situ growth of zeolite imidazole skeleton on regenerated cellulose aerogel for efficient removal of tetracycline.
32574729	6	17	theme	regenerated	857:867	arg1	aerogel					879:885	regenerated cellulose aerogel	857:885	regenerated cellulose aerogel	857:885	Finally, ZIF-67 nanocrystals were in-situ growth on the surface of the PANI coated regenerated cellulose aerogel to synthesise the composite adsorbent ZIF-67/PANI/RCA.
32574729	6	18	from	growth	816:821	arg1	surface					830:836	the surface	826:836	the surface of the PANI coated regenerated cellulose aerogel to synthesise the composite adsorbent ZIF-67/PANI/RCA	826:939	Finally, ZIF-67 nanocrystals were in-situ growth on the surface of the PANI coated regenerated cellulose aerogel to synthesise the composite adsorbent ZIF-67/PANI/RCA.
32574729	7	19	theme	pure	1147:1150	arg1	RCA					1152:1154	pure RCA	1147:1154	pure RCA	1147:1154	The loading mass ratios of ZIF-67 on RCA and PANI/RCA were 25.39% and 42.38%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA.
32574729	1	20	theme	emerging	184:191	arg1	pollutants					201:210	newly emerging organic pollutants	178:210	newly emerging organic pollutants	178:210	Antibiotics as newly emerging organic pollutants are arousing more and more serious environmental issues.
32574729	3	21	theme	large-scale	404:414	arg1	applications					416:427	large-scale applications	404:427	large-scale applications for MOFs in the powder form	404:455	To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA).
32574729	10	22	theme	MOF	1503:1505	arg1	mass					1515:1518	MOF loading mass	1503:1518	MOF loading mass on aerogel	1503:1529	This strategy may provide an effective and versatile pathway to increase MOF loading mass on aerogel and sequentially branch out their applications in pollutant treatment fields.
32574729	2	23	theme	promising	329:337	arg1	Meantime					269:276	Meantime	269:276	Meantime	269:276	Meantime, metal-organic frameworks (MOFs) are considered as promising adsorbents to remove antibiotics.
32574729	2	23	theme	promising	329:337	arg1	adsorbents					339:348	promising adsorbents	329:348	promising adsorbents	329:348	Meantime, metal-organic frameworks (MOFs) are considered as promising adsorbents to remove antibiotics.
32574729	7	24	dep	%	1006:1006	arg1	indicates					1040:1048	indicates	1040:1048	indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA	1040:1154	The loading mass ratios of ZIF-67 on RCA and PANI/RCA were 25.39% and 42.38%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA.
32574729	3	25	theme	powder	445:450	arg1	form					452:455	the powder form	441:455	the powder form	441:455	To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA).
32574729	3	26	theme	applications	416:427	arg1	limitations					389:399	the limitations	385:399	the limitations of large-scale applications for MOFs in the powder form	385:455	To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA).
32574729	7	27	from	ratios	959:964	arg1	RCA					979:981	RCA	979:981	RCA	979:981	The loading mass ratios of ZIF-67 on RCA and PANI/RCA were 25.39% and 42.38%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA.
32574729	7	27	from	ratios	959:964	arg1	PANI/RCA					987:994	PANI/RCA	987:994	PANI/RCA	987:994	The loading mass ratios of ZIF-67 on RCA and PANI/RCA were 25.39% and 42.38%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA.
32574729	8	28	theme	recycling	1315:1323	arg1	ability					1325:1331	good recycling ability	1310:1331	good recycling ability	1310:1331	The obtained composite adsorbent (ZIF-67/PANI/RCA) was applied for the adsorption of tetracycline (TC) with high adsorption capacity (409.55 mg·g-1) and good recycling ability.
32574729	10	29	theme	treatment	1591:1599	arg1	fields					1601:1606	pollutant treatment fields	1581:1606	pollutant treatment fields	1581:1606	This strategy may provide an effective and versatile pathway to increase MOF loading mass on aerogel and sequentially branch out their applications in pollutant treatment fields.
32574729	7	30	theme	ZIF-67	1126:1131	arg1	growth					1116:1121	the in-situ growth	1104:1121	the in-situ growth of ZIF-67	1104:1131	The loading mass ratios of ZIF-67 on RCA and PANI/RCA were 25.39% and 42.38%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA.
32574729	0	31	theme	efficient	128:136	arg1	removal					138:144	efficient removal	128:144	efficient removal of tetracycline	128:160	Polyaniline as interface layers promoting the in-situ growth of zeolite imidazole skeleton on regenerated cellulose aerogel for efficient removal of tetracycline.
32574729	7	32	theme	mass	954:957	arg1	ratios					959:964	The loading mass ratios	942:964	The loading mass ratios of ZIF-67 on RCA and PANI/RCA	942:994	The loading mass ratios of ZIF-67 on RCA and PANI/RCA were 25.39% and 42.38%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA.
32574729	7	32	theme	mass	954:957	arg1	%					1006:1006	25.39%	1001:1006	25.39%	1001:1006	The loading mass ratios of ZIF-67 on RCA and PANI/RCA were 25.39% and 42.38%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA.
32574729	3	33	theme	cellulose	559:567	arg1	aerogel					569:575	regenerated cellulose aerogel	547:575	regenerated cellulose aerogel (RCA)	547:581	To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA).
32574729	3	33	theme	cellulose	559:567	arg1	RCA					578:580	RCA	578:580	RCA	578:580	To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA).
32574729	0	34	theme	interface	15:23	arg1	layers					25:30	interface layers	15:30	interface layers	15:30	Polyaniline as interface layers promoting the in-situ growth of zeolite imidazole skeleton on regenerated cellulose aerogel for efficient removal of tetracycline.
32574729	6	35	theme	PANI	845:848	arg1	surface					830:836	the surface	826:836	the surface of the PANI coated regenerated cellulose aerogel to synthesise the composite adsorbent ZIF-67/PANI/RCA	826:939	Finally, ZIF-67 nanocrystals were in-situ growth on the surface of the PANI coated regenerated cellulose aerogel to synthesise the composite adsorbent ZIF-67/PANI/RCA.
32574729	1	36	theme	arousing	216:223	arg1	issues					261:266	arousing more and more serious environmental issues	216:266	arousing more and more serious environmental issues	216:266	Antibiotics as newly emerging organic pollutants are arousing more and more serious environmental issues.
32574729	1	36	theme	arousing	216:223	arg1	Antibiotics					163:173	Antibiotics	163:173	Antibiotics as newly emerging organic pollutants	163:210	Antibiotics as newly emerging organic pollutants are arousing more and more serious environmental issues.
32574729	5	37	theme	in-situ	750:756	arg1	polymerization					758:771	in-situ polymerization	750:771	in-situ polymerization	750:771	Then, PANI played the role of metal chelated layers, which were coated on RCA by in-situ polymerization.
32574729	5	38	theme	metal	699:703	arg1	layers					714:719	metal chelated layers	699:719	metal chelated layers	699:719	Then, PANI played the role of metal chelated layers, which were coated on RCA by in-situ polymerization.
32574729	8	39	theme	tetracycline	1242:1253	arg1	adsorption					1228:1237	the adsorption	1224:1237	the adsorption of tetracycline (TC) with high adsorption capacity (409.55 mg·g-1) and good recycling ability	1224:1331	The obtained composite adsorbent (ZIF-67/PANI/RCA) was applied for the adsorption of tetracycline (TC) with high adsorption capacity (409.55 mg·g-1) and good recycling ability.
32574729	4	40	theme	physical	638:645	arg1	method					661:666	physical cross-linking method	638:666	physical cross-linking method	638:666	First, RCA was obtained by chemical cross-linking and physical cross-linking method.
32574729	5	41	theme	chelated	705:712	arg1	layers					714:719	metal chelated layers	699:719	metal chelated layers	699:719	Then, PANI played the role of metal chelated layers, which were coated on RCA by in-situ polymerization.
32574729	10	42	theme	loading	1507:1513	arg1	mass					1515:1518	MOF loading mass	1503:1518	MOF loading mass on aerogel	1503:1529	This strategy may provide an effective and versatile pathway to increase MOF loading mass on aerogel and sequentially branch out their applications in pollutant treatment fields.
32574729	5	43	theme	layers	714:719	arg1	role					691:694	the role	687:694	the role	687:694	Then, PANI played the role of metal chelated layers, which were coated on RCA by in-situ polymerization.
32574729	10	44	theme	versatile	1473:1481	arg1	pathway					1483:1489	an effective and versatile pathway	1456:1489	an effective and versatile pathway to increase MOF loading mass on aerogel and sequentially branch out their applications in pollutant treatment fields	1456:1606	This strategy may provide an effective and versatile pathway to increase MOF loading mass on aerogel and sequentially branch out their applications in pollutant treatment fields.
32574729	1	45	dep	serious	239:245	arg1	environmental					247:259	environmental	247:259	environmental	247:259	Antibiotics as newly emerging organic pollutants are arousing more and more serious environmental issues.
32574729	8	46	with	adsorption	1228:1237	arg1	ability					1325:1331	good recycling ability	1310:1331	good recycling ability	1310:1331	The obtained composite adsorbent (ZIF-67/PANI/RCA) was applied for the adsorption of tetracycline (TC) with high adsorption capacity (409.55 mg·g-1) and good recycling ability.
32574729	8	46	with	adsorption	1228:1237	arg1	409.55 mg·g-1					1291:1303	409.55 mg·g-1	1291:1303	409.55 mg·g-1	1291:1303	The obtained composite adsorbent (ZIF-67/PANI/RCA) was applied for the adsorption of tetracycline (TC) with high adsorption capacity (409.55 mg·g-1) and good recycling ability.
32574729	8	46	with	adsorption	1228:1237	arg1	capacity					1281:1288	high adsorption capacity	1265:1288	high adsorption capacity (409.55 mg·g-1)	1265:1304	The obtained composite adsorbent (ZIF-67/PANI/RCA) was applied for the adsorption of tetracycline (TC) with high adsorption capacity (409.55 mg·g-1) and good recycling ability.
32574729	3	47	theme	in-situ	492:498	arg1	ZIF-67					507:512	in-situ growth ZIF-67	492:512	in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA)	492:581	To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA).
32574729	0	48	theme	in-situ	46:52	arg1	growth					54:59	the in-situ growth	42:59	the in-situ growth of zeolite imidazole skeleton on regenerated cellulose aerogel for efficient removal of tetracycline	42:160	Polyaniline as interface layers promoting the in-situ growth of zeolite imidazole skeleton on regenerated cellulose aerogel for efficient removal of tetracycline.
32574729	0	49	theme	tetracycline	149:160	arg1	removal					138:144	efficient removal	128:144	efficient removal of tetracycline	128:160	Polyaniline as interface layers promoting the in-situ growth of zeolite imidazole skeleton on regenerated cellulose aerogel for efficient removal of tetracycline.
32574729	10	50	from	mass	1515:1518	arg1	aerogel					1523:1529	aerogel	1523:1529	aerogel	1523:1529	This strategy may provide an effective and versatile pathway to increase MOF loading mass on aerogel and sequentially branch out their applications in pollutant treatment fields.
32574729	7	51	theme	interface	1063:1071	arg1	layers					1073:1078	interface layers	1063:1078	interface layers	1063:1078	The loading mass ratios of ZIF-67 on RCA and PANI/RCA were 25.39% and 42.38%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA.
32574729	3	52	theme	growth	500:505	arg1	ZIF-67					507:512	in-situ growth ZIF-67	492:512	in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA)	492:581	To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA).
32574729	10	53	theme	pollutant	1581:1589	arg1	fields					1601:1606	pollutant treatment fields	1581:1606	pollutant treatment fields	1581:1606	This strategy may provide an effective and versatile pathway to increase MOF loading mass on aerogel and sequentially branch out their applications in pollutant treatment fields.
32574729	6	54	theme	adsorbent	915:923	arg1	ZIF-67/PANI/RCA					925:939	the composite adsorbent ZIF-67/PANI/RCA	901:939	the composite adsorbent ZIF-67/PANI/RCA	901:939	Finally, ZIF-67 nanocrystals were in-situ growth on the surface of the PANI coated regenerated cellulose aerogel to synthesise the composite adsorbent ZIF-67/PANI/RCA.
32574729	7	55	theme	in-situ	1108:1114	arg1	growth					1116:1121	the in-situ growth	1104:1121	the in-situ growth of ZIF-67	1104:1131	The loading mass ratios of ZIF-67 on RCA and PANI/RCA were 25.39% and 42.38%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA.
32574729	2	56	theme	metal-organic	279:291	arg1	MOFs					305:308	MOFs	305:308	MOFs	305:308	Meantime, metal-organic frameworks (MOFs) are considered as promising adsorbents to remove antibiotics.
32574729	2	56	theme	metal-organic	279:291	arg1	Meantime					269:276	Meantime	269:276	Meantime	269:276	Meantime, metal-organic frameworks (MOFs) are considered as promising adsorbents to remove antibiotics.
32574729	2	56	theme	metal-organic	279:291	arg1	frameworks					293:302	metal-organic frameworks	279:302	metal-organic frameworks (MOFs)	279:309	Meantime, metal-organic frameworks (MOFs) are considered as promising adsorbents to remove antibiotics.
32574729	8	57	theme	adsorption	1270:1279	arg1	409.55 mg·g-1					1291:1303	409.55 mg·g-1	1291:1303	409.55 mg·g-1	1291:1303	The obtained composite adsorbent (ZIF-67/PANI/RCA) was applied for the adsorption of tetracycline (TC) with high adsorption capacity (409.55 mg·g-1) and good recycling ability.
32574729	8	57	theme	adsorption	1270:1279	arg1	capacity					1281:1288	high adsorption capacity	1265:1288	high adsorption capacity (409.55 mg·g-1)	1265:1304	The obtained composite adsorbent (ZIF-67/PANI/RCA) was applied for the adsorption of tetracycline (TC) with high adsorption capacity (409.55 mg·g-1) and good recycling ability.
32574729	1	58	theme	serious	239:245	arg1	issues					261:266	arousing more and more serious environmental issues	216:266	arousing more and more serious environmental issues	216:266	Antibiotics as newly emerging organic pollutants are arousing more and more serious environmental issues.
32574729	1	58	theme	serious	239:245	arg1	Antibiotics					163:173	Antibiotics	163:173	Antibiotics as newly emerging organic pollutants	163:210	Antibiotics as newly emerging organic pollutants are arousing more and more serious environmental issues.
32574729	0	59	theme	zeolite	64:70	arg1	skeleton					82:89	zeolite imidazole skeleton	64:89	zeolite imidazole skeleton	64:89	Polyaniline as interface layers promoting the in-situ growth of zeolite imidazole skeleton on regenerated cellulose aerogel for efficient removal of tetracycline.
32574729	6	60	theme	in-situ	808:814	arg1	growth					816:821	in-situ growth	808:821	in-situ growth on the surface of the PANI coated regenerated cellulose aerogel to synthesise the composite adsorbent ZIF-67/PANI/RCA	808:939	Finally, ZIF-67 nanocrystals were in-situ growth on the surface of the PANI coated regenerated cellulose aerogel to synthesise the composite adsorbent ZIF-67/PANI/RCA.
32574729	10	61	theme	effective	1459:1467	arg1	pathway					1483:1489	an effective and versatile pathway	1456:1489	an effective and versatile pathway to increase MOF loading mass on aerogel and sequentially branch out their applications in pollutant treatment fields	1456:1606	This strategy may provide an effective and versatile pathway to increase MOF loading mass on aerogel and sequentially branch out their applications in pollutant treatment fields.
32574729	3	62	theme	polyaniline	519:529	arg1	PANI					532:535	polyaniline (PANI)	519:536	polyaniline (PANI) modified regenerated cellulose aerogel (RCA)	519:581	To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-67 onto polyaniline (PANI) modified regenerated cellulose aerogel (RCA).
32574729	4	63	theme	cross-linking	647:659	arg1	method					661:666	physical cross-linking method	638:666	physical cross-linking method	638:666	First, RCA was obtained by chemical cross-linking and physical cross-linking method.
32574729	6	64	theme	composite	905:913	arg1	ZIF-67/PANI/RCA					925:939	the composite adsorbent ZIF-67/PANI/RCA	901:939	the composite adsorbent ZIF-67/PANI/RCA	901:939	Finally, ZIF-67 nanocrystals were in-situ growth on the surface of the PANI coated regenerated cellulose aerogel to synthesise the composite adsorbent ZIF-67/PANI/RCA.
32574729	7	65	theme	ZIF-67	969:974	arg1	ratios					959:964	The loading mass ratios	942:964	The loading mass ratios of ZIF-67 on RCA and PANI/RCA	942:994	The loading mass ratios of ZIF-67 on RCA and PANI/RCA were 25.39% and 42.38%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA.
32574729	7	65	theme	ZIF-67	969:974	arg1	%					1006:1006	25.39%	1001:1006	25.39%	1001:1006	The loading mass ratios of ZIF-67 on RCA and PANI/RCA were 25.39% and 42.38%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-67 compared with pure RCA.
32574729	8	66	theme	high	1265:1268	arg1	409.55 mg·g-1					1291:1303	409.55 mg·g-1	1291:1303	409.55 mg·g-1	1291:1303	The obtained composite adsorbent (ZIF-67/PANI/RCA) was applied for the adsorption of tetracycline (TC) with high adsorption capacity (409.55 mg·g-1) and good recycling ability.
32574729	8	66	theme	high	1265:1268	arg1	capacity					1281:1288	high adsorption capacity	1265:1288	high adsorption capacity (409.55 mg·g-1)	1265:1304	The obtained composite adsorbent (ZIF-67/PANI/RCA) was applied for the adsorption of tetracycline (TC) with high adsorption capacity (409.55 mg·g-1) and good recycling ability.
32574729	9	67	theme	adsorption-desorption	1354:1374	arg1	cycles					1344:1349	six cycles	1340:1349	six cycles of adsorption-desorption	1340:1374	After six cycles of adsorption-desorption, the removal efficiency toward TC was still over 94%.
34487117	0	0	theme	Wounds	96:101	arg1	Healing					76:82	the Accelerated Healing	60:82	the Accelerated Healing of Diabetic Wounds	60:101	Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds.
34487117	4	1	link	crosslinked	539:549	arg1	scaffolds					556:564	crosslinked (CL) scaffolds	539:564	crosslinked (CL) scaffolds	539:564	The current study aims to formulate DOX loaded collagen-chitosan non-crosslinked (NCL) & crosslinked (CL) scaffolds and evaluate their healing ability in diabetic conditions.
34487117	5	2	theme	degradation	738:748	arg1	rate					750:753	a low swelling & degradation rate	721:753	a low swelling & degradation rate	721:753	The characterization result of scaffolds reveals that the DOX-CL scaffold holds ideal porosity, a low swelling & degradation rate, and a sustained release of DOX compared to the DOX-NCL scaffold.
34487117	5	3	dep	characterization	629:644	arg1	result					646:651	result	646:651	result	646:651	The characterization result of scaffolds reveals that the DOX-CL scaffold holds ideal porosity, a low swelling & degradation rate, and a sustained release of DOX compared to the DOX-NCL scaffold.
34487117	0	4	theme	Diabetic	87:94	arg1	Wounds					96:101	Diabetic Wounds	87:101	Diabetic Wounds	87:101	Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds.
34487117	7	5	theme	common	1091:1096	arg1	bacteria					1098:1105	the most common bacteria	1082:1105	the most common bacteria found in DW	1082:1117	The anti-bacterial studies have shown that the DOX-CL scaffold was more effective than the CL scaffold against the most common bacteria found in DW.
34487117	6	6	theme	control	955:961	arg1	groups					963:968	CL scaffold treated and control groups	931:968	CL scaffold treated and control groups	931:968	The in vitro studies reveal that the DOX-CL scaffold was biocompatible and enhanced cell growth compared with CL scaffold treated and control groups.
34487117	6	7	theme	DOX-CL	858:863	arg1	scaffold					865:872	the DOX-CL scaffold	854:872	the DOX-CL scaffold	854:872	The in vitro studies reveal that the DOX-CL scaffold was biocompatible and enhanced cell growth compared with CL scaffold treated and control groups.
34487117	6	7	theme	DOX-CL	858:863	arg1	biocompatible					878:890	biocompatible	878:890	biocompatible	878:890	The in vitro studies reveal that the DOX-CL scaffold was biocompatible and enhanced cell growth compared with CL scaffold treated and control groups.
34487117	7	8	located	found	1107:1111	arg2	bacteria					1098:1105	the most common bacteria	1082:1105	the most common bacteria found in DW	1082:1117	The anti-bacterial studies have shown that the DOX-CL scaffold was more effective than the CL scaffold against the most common bacteria found in DW.
34487117	7	8	located	found	1107:1111	arg1	DW					1116:1117	DW	1116:1117	DW	1116:1117	The anti-bacterial studies have shown that the DOX-CL scaffold was more effective than the CL scaffold against the most common bacteria found in DW.
34487117	2	9	theme	wound	282:286	arg1	healing					288:294	delayed wound healing	274:294	delayed wound healing	274:294	The prolonged phase of inflammation in diabetes obstructs the further stages of an injury leading to delayed wound healing.
34487117	2	10	from	phase	187:191	arg1	diabetes					212:219	diabetes	212:219	diabetes	212:219	The prolonged phase of inflammation in diabetes obstructs the further stages of an injury leading to delayed wound healing.
34487117	4	11	theme	current	454:460	arg1	study					462:466	The current study	450:466	The current study	450:466	The current study aims to formulate DOX loaded collagen-chitosan non-crosslinked (NCL) & crosslinked (CL) scaffolds and evaluate their healing ability in diabetic conditions.
34487117	2	12	theme	delayed	274:280	arg1	healing					288:294	delayed wound healing	274:294	delayed wound healing	274:294	The prolonged phase of inflammation in diabetes obstructs the further stages of an injury leading to delayed wound healing.
34487117	6	13	theme	treated	943:949	arg1	groups					963:968	CL scaffold treated and control groups	931:968	CL scaffold treated and control groups	931:968	The in vitro studies reveal that the DOX-CL scaffold was biocompatible and enhanced cell growth compared with CL scaffold treated and control groups.
34487117	4	14	dep	crosslinked	539:549	arg1	CL					552:553	CL	552:553	CL	552:553	The current study aims to formulate DOX loaded collagen-chitosan non-crosslinked (NCL) & crosslinked (CL) scaffolds and evaluate their healing ability in diabetic conditions.
34487117	8	15	theme	contraction	1227:1237	arg1	rate					1213:1216	a significantly (p≤0.05) faster rate	1181:1216	a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group	1181:1274	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	8	16	theme	high-fat	1149:1156	arg1	model					1174:1178	the streptozotocin and high-fat diet-induced DW model	1126:1178	the streptozotocin and high-fat diet-induced DW model	1126:1178	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	9	17	theme	DOX-CL	1365:1370	arg1	scaffold					1372:1379	the DOX-CL scaffold	1361:1379	the DOX-CL scaffold	1361:1379	The use of the DOX-CL scaffold can prove to be a promising approach for local treatment for DWs.
34487117	5	18	theme	low	723:725	arg1	rate					750:753	a low swelling & degradation rate	721:753	a low swelling & degradation rate	721:753	The characterization result of scaffolds reveals that the DOX-CL scaffold holds ideal porosity, a low swelling & degradation rate, and a sustained release of DOX compared to the DOX-NCL scaffold.
34487117	7	19	theme	CL	1062:1063	arg1	scaffold					1065:1072	the CL scaffold	1058:1072	the CL scaffold	1058:1072	The anti-bacterial studies have shown that the DOX-CL scaffold was more effective than the CL scaffold against the most common bacteria found in DW.
34487117	8	20	dep	faster	1206:1211	arg1	p≤0.05					1198:1203	p≤0.05	1198:1203	p≤0.05	1198:1203	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	9	21	theme	scaffold	1372:1379	arg1	use					1354:1356	The use	1350:1356	The use of the DOX-CL scaffold	1350:1379	The use of the DOX-CL scaffold can prove to be a promising approach for local treatment for DWs.
34487117	9	21	theme	scaffold	1372:1379	arg1	approach					1409:1416	a promising approach	1397:1416	a promising approach for local treatment for DWs	1397:1444	The use of the DOX-CL scaffold can prove to be a promising approach for local treatment for DWs.
34487117	3	22	theme	choice	351:356	arg1	drug					343:346	a potential drug	331:346	a potential drug of choice	331:356	We selected doxycycline (DOX), as a potential drug of choice, due to its anti-bacterial properties along with its reported anti-inflammatory properties.
34487117	3	22	theme	choice	351:356	arg1	doxycycline					309:319	doxycycline	309:319	doxycycline (DOX)	309:325	We selected doxycycline (DOX), as a potential drug of choice, due to its anti-bacterial properties along with its reported anti-inflammatory properties.
34487117	8	23	theme	CL	1310:1311	arg1	groups					1342:1347	CL scaffold treated and control groups	1310:1347	CL scaffold treated and control groups	1310:1347	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	8	24	theme	streptozotocin	1130:1143	arg1	model					1174:1178	the streptozotocin and high-fat diet-induced DW model	1126:1178	the streptozotocin and high-fat diet-induced DW model	1126:1178	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	6	25	theme	scaffold	934:941	arg1	groups					963:968	CL scaffold treated and control groups	931:968	CL scaffold treated and control groups	931:968	The in vitro studies reveal that the DOX-CL scaffold was biocompatible and enhanced cell growth compared with CL scaffold treated and control groups.
34487117	8	26	theme	faster	1206:1211	arg1	rate					1213:1216	a significantly (p≤0.05) faster rate	1181:1216	a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group	1181:1274	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	6	27	theme	in	825:826	arg1	studies					834:840	The in vitro studies	821:840	The in vitro studies	821:840	The in vitro studies reveal that the DOX-CL scaffold was biocompatible and enhanced cell growth compared with CL scaffold treated and control groups.
34487117	0	28	theme	Composite	37:45	arg1	Scaffold					47:54	Collagen-Chitosan Composite Scaffold	19:54	Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds	19:101	Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds.
34487117	6	29	theme	CL	931:932	arg1	groups					963:968	CL scaffold treated and control groups	931:968	CL scaffold treated and control groups	931:968	The in vitro studies reveal that the DOX-CL scaffold was biocompatible and enhanced cell growth compared with CL scaffold treated and control groups.
34487117	5	30	theme	DOX-CL	683:688	arg1	scaffold					690:697	the DOX-CL scaffold	679:697	the DOX-CL scaffold	679:697	The characterization result of scaffolds reveals that the DOX-CL scaffold holds ideal porosity, a low swelling & degradation rate, and a sustained release of DOX compared to the DOX-NCL scaffold.
34487117	8	31	theme	diet-induced	1158:1169	arg1	model					1174:1178	the streptozotocin and high-fat diet-induced DW model	1126:1178	the streptozotocin and high-fat diet-induced DW model	1126:1178	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	1	32	theme	major	108:112	arg1	complication					114:125	One major complication	104:125	One major complication of diabetes mellitus	104:146	One major complication of diabetes mellitus is diabetic wounds (DW).
34487117	8	33	theme	control	1334:1340	arg1	groups					1342:1347	CL scaffold treated and control groups	1310:1347	CL scaffold treated and control groups	1310:1347	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	4	34	theme	diabetic	604:611	arg1	conditions					613:622	diabetic conditions	604:622	diabetic conditions	604:622	The current study aims to formulate DOX loaded collagen-chitosan non-crosslinked (NCL) & crosslinked (CL) scaffolds and evaluate their healing ability in diabetic conditions.
34487117	0	35	theme	Collagen-Chitosan	19:35	arg1	Scaffold					47:54	Collagen-Chitosan Composite Scaffold	19:54	Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds	19:101	Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds.
34487117	9	36	theme	local	1422:1426	arg1	treatment					1428:1436	local treatment	1422:1436	local treatment for DWs	1422:1444	The use of the DOX-CL scaffold can prove to be a promising approach for local treatment for DWs.
34487117	2	37	theme	prolonged	177:185	arg1	phase					187:191	The prolonged phase	173:191	The prolonged phase of inflammation in diabetes	173:219	The prolonged phase of inflammation in diabetes obstructs the further stages of an injury leading to delayed wound healing.
34487117	8	38	theme	scaffold	1313:1320	arg1	groups					1342:1347	CL scaffold treated and control groups	1310:1347	CL scaffold treated and control groups	1310:1347	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	5	39	theme	DOX	783:785	arg1	porosity					711:718	ideal porosity	705:718	ideal porosity	705:718	The characterization result of scaffolds reveals that the DOX-CL scaffold holds ideal porosity, a low swelling & degradation rate, and a sustained release of DOX compared to the DOX-NCL scaffold.
34487117	5	39	theme	DOX	783:785	arg1	release					772:778	a sustained release	760:778	a sustained release of DOX	760:785	The characterization result of scaffolds reveals that the DOX-CL scaffold holds ideal porosity, a low swelling & degradation rate, and a sustained release of DOX compared to the DOX-NCL scaffold.
34487117	5	39	theme	DOX	783:785	arg1	rate					750:753	a low swelling & degradation rate	721:753	a low swelling & degradation rate	721:753	The characterization result of scaffolds reveals that the DOX-CL scaffold holds ideal porosity, a low swelling & degradation rate, and a sustained release of DOX compared to the DOX-NCL scaffold.
34487117	4	40	theme	crosslinked	539:549	arg1	scaffolds					556:564	crosslinked (CL) scaffolds	539:564	crosslinked (CL) scaffolds	539:564	The current study aims to formulate DOX loaded collagen-chitosan non-crosslinked (NCL) & crosslinked (CL) scaffolds and evaluate their healing ability in diabetic conditions.
34487117	7	41	theme	DOX-CL	1018:1023	arg1	scaffold					1025:1032	the DOX-CL scaffold	1014:1032	the DOX-CL scaffold	1014:1032	The anti-bacterial studies have shown that the DOX-CL scaffold was more effective than the CL scaffold against the most common bacteria found in DW.
34487117	7	41	theme	DOX-CL	1018:1023	arg1	effective					1043:1051	effective	1043:1051	effective	1043:1051	The anti-bacterial studies have shown that the DOX-CL scaffold was more effective than the CL scaffold against the most common bacteria found in DW.
34487117	5	42	theme	DOX-NCL	803:809	arg1	scaffold					811:818	the DOX-NCL scaffold	799:818	the DOX-NCL scaffold	799:818	The characterization result of scaffolds reveals that the DOX-CL scaffold holds ideal porosity, a low swelling & degradation rate, and a sustained release of DOX compared to the DOX-NCL scaffold.
34487117	2	43	theme	further	235:241	arg1	stages					243:248	the further stages	231:248	the further stages of an injury leading to delayed wound healing	231:294	The prolonged phase of inflammation in diabetes obstructs the further stages of an injury leading to delayed wound healing.
34487117	3	44	theme	reported	411:418	arg1	properties					438:447	its reported anti-inflammatory properties	407:447	its anti-bacterial properties along with its reported anti-inflammatory properties	366:447	We selected doxycycline (DOX), as a potential drug of choice, due to its anti-bacterial properties along with its reported anti-inflammatory properties.
34487117	3	45	theme	anti-bacterial	370:383	arg1	properties					385:394	its anti-bacterial properties	366:394	its anti-bacterial properties along with its reported anti-inflammatory properties	366:447	We selected doxycycline (DOX), as a potential drug of choice, due to its anti-bacterial properties along with its reported anti-inflammatory properties.
34487117	5	46	theme	ideal	705:709	arg1	porosity					711:718	ideal porosity	705:718	ideal porosity	705:718	The characterization result of scaffolds reveals that the DOX-CL scaffold holds ideal porosity, a low swelling & degradation rate, and a sustained release of DOX compared to the DOX-NCL scaffold.
34487117	8	47	theme	wound	1221:1225	arg1	contraction					1227:1237	wound contraction	1221:1237	wound contraction	1221:1237	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	3	48	dep	along	396:400	arg1	with					402:405	with	402:405	with	402:405	We selected doxycycline (DOX), as a potential drug of choice, due to its anti-bacterial properties along with its reported anti-inflammatory properties.
34487117	7	49	theme	anti-bacterial	975:988	arg1	studies					990:996	The anti-bacterial studies	971:996	The anti-bacterial studies	971:996	The anti-bacterial studies have shown that the DOX-CL scaffold was more effective than the CL scaffold against the most common bacteria found in DW.
34487117	3	50	theme	anti-inflammatory	420:436	arg1	properties					438:447	its reported anti-inflammatory properties	407:447	its anti-bacterial properties along with its reported anti-inflammatory properties	366:447	We selected doxycycline (DOX), as a potential drug of choice, due to its anti-bacterial properties along with its reported anti-inflammatory properties.
34487117	0	51	theme	Accelerated	64:74	arg1	Healing					76:82	the Accelerated Healing	60:82	the Accelerated Healing of Diabetic Wounds	60:101	Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds.
34487117	4	52	dep	DOX	486:488	arg1	&					537:537	&	537:537	& crosslinked (CL) scaffolds	537:564	The current study aims to formulate DOX loaded collagen-chitosan non-crosslinked (NCL) & crosslinked (CL) scaffolds and evaluate their healing ability in diabetic conditions.
34487117	4	52	dep	DOX	486:488	arg1	evaluate					570:577	evaluate	570:577	evaluate their healing ability in diabetic conditions	570:622	The current study aims to formulate DOX loaded collagen-chitosan non-crosslinked (NCL) & crosslinked (CL) scaffolds and evaluate their healing ability in diabetic conditions.
34487117	5	53	theme	scaffolds	656:664	arg1	characterization					629:644	The characterization result	625:651	The characterization result of scaffolds	625:664	The characterization result of scaffolds reveals that the DOX-CL scaffold holds ideal porosity, a low swelling & degradation rate, and a sustained release of DOX compared to the DOX-NCL scaffold.
34487117	5	54	theme	sustained	762:770	arg1	release					772:778	a sustained release	760:778	a sustained release of DOX	760:785	The characterization result of scaffolds reveals that the DOX-CL scaffold holds ideal porosity, a low swelling & degradation rate, and a sustained release of DOX compared to the DOX-NCL scaffold.
34487117	8	55	theme	DW	1171:1172	arg1	model					1174:1178	the streptozotocin and high-fat diet-induced DW model	1126:1178	the streptozotocin and high-fat diet-induced DW model	1126:1178	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	1	56	theme	diabetes	130:137	arg1	mellitus					139:146	diabetes mellitus	130:146	diabetes mellitus	130:146	One major complication of diabetes mellitus is diabetic wounds (DW).
34487117	6	57	dep	in	825:826	arg1	vitro					828:832	vitro	828:832	vitro	828:832	The in vitro studies reveal that the DOX-CL scaffold was biocompatible and enhanced cell growth compared with CL scaffold treated and control groups.
34487117	2	58	theme	inflammation	196:207	arg1	phase					187:191	The prolonged phase	173:191	The prolonged phase of inflammation in diabetes	173:219	The prolonged phase of inflammation in diabetes obstructs the further stages of an injury leading to delayed wound healing.
34487117	2	59	theme	injury	256:261	arg1	stages					243:248	the further stages	231:248	the further stages of an injury leading to delayed wound healing	231:294	The prolonged phase of inflammation in diabetes obstructs the further stages of an injury leading to delayed wound healing.
34487117	1	60	theme	mellitus	139:146	arg1	complication					114:125	One major complication	104:125	One major complication of diabetes mellitus	104:146	One major complication of diabetes mellitus is diabetic wounds (DW).
34487117	8	61	theme	treated	1322:1328	arg1	groups					1342:1347	CL scaffold treated and control groups	1310:1347	CL scaffold treated and control groups	1310:1347	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	8	62	theme	treated	1262:1268	arg1	group					1270:1274	the DOX-CL scaffold treated group	1242:1274	the DOX-CL scaffold treated group	1242:1274	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	8	63	theme	DOX-CL	1246:1251	arg1	group					1270:1274	the DOX-CL scaffold treated group	1242:1274	the DOX-CL scaffold treated group	1242:1274	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	5	64	theme	swelling	727:734	arg1	rate					750:753	a low swelling & degradation rate	721:753	a low swelling & degradation rate	721:753	The characterization result of scaffolds reveals that the DOX-CL scaffold holds ideal porosity, a low swelling & degradation rate, and a sustained release of DOX compared to the DOX-NCL scaffold.
34487117	9	65	theme	promising	1399:1407	arg1	use					1354:1356	The use	1350:1356	The use of the DOX-CL scaffold	1350:1379	The use of the DOX-CL scaffold can prove to be a promising approach for local treatment for DWs.
34487117	9	65	theme	promising	1399:1407	arg1	approach					1409:1416	a promising approach	1397:1416	a promising approach for local treatment for DWs	1397:1444	The use of the DOX-CL scaffold can prove to be a promising approach for local treatment for DWs.
34487117	1	66	theme	diabetic	151:158	arg1	wounds					160:165	diabetic wounds	151:165	diabetic wounds (DW)	151:170	One major complication of diabetes mellitus is diabetic wounds (DW).
34487117	1	66	theme	diabetic	151:158	arg1	DW					168:169	DW	168:169	DW	168:169	One major complication of diabetes mellitus is diabetic wounds (DW).
34487117	5	67	theme	&	736:736	arg1	rate					750:753	a low swelling & degradation rate	721:753	a low swelling & degradation rate	721:753	The characterization result of scaffolds reveals that the DOX-CL scaffold holds ideal porosity, a low swelling & degradation rate, and a sustained release of DOX compared to the DOX-NCL scaffold.
34487117	4	68	theme	healing	585:591	arg1	ability					593:599	their healing ability	579:599	their healing ability	579:599	The current study aims to formulate DOX loaded collagen-chitosan non-crosslinked (NCL) & crosslinked (CL) scaffolds and evaluate their healing ability in diabetic conditions.
34487117	8	69	from	rate	1213:1216	arg1	group					1270:1274	the DOX-CL scaffold treated group	1242:1274	the DOX-CL scaffold treated group	1242:1274	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	8	70	theme	scaffold	1253:1260	arg1	group					1270:1274	the DOX-CL scaffold treated group	1242:1274	the DOX-CL scaffold treated group	1242:1274	Using the streptozotocin and high-fat diet-induced DW model, a significantly (p≤0.05) faster rate of wound contraction in the DOX-CL scaffold treated group was observed compared to those in CL scaffold treated and control groups.
34487117	6	71	theme	cell	905:908	arg1	growth					910:915	cell growth	905:915	cell growth	905:915	The in vitro studies reveal that the DOX-CL scaffold was biocompatible and enhanced cell growth compared with CL scaffold treated and control groups.
34487117	3	72	theme	potential	333:341	arg1	drug					343:346	a potential drug	331:346	a potential drug of choice	331:356	We selected doxycycline (DOX), as a potential drug of choice, due to its anti-bacterial properties along with its reported anti-inflammatory properties.
34487117	3	72	theme	potential	333:341	arg1	doxycycline					309:319	doxycycline	309:319	doxycycline (DOX)	309:325	We selected doxycycline (DOX), as a potential drug of choice, due to its anti-bacterial properties along with its reported anti-inflammatory properties.
34623206	0	0	theme	wound	89:93	arg1	healing					95:101	corneal wound healing	81:101	corneal wound healing	81:101	Gelatin hydrogel/contact lens composites as rutin delivery systems for promoting corneal wound healing.
34623206	4	1	theme	safe	486:489	arg1	method					505:510	a safe and effective method	484:510	a safe and effective method for treating corneal injury	484:538	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	10	2	theme	intervention	1460:1471	arg1	strategy					1473:1480	a potential intervention strategy	1448:1480	a potential intervention strategy to facilitate corneal wound healing in humans	1448:1526	These results inform a potential intervention strategy to facilitate corneal wound healing in humans.
34623206	8	3	from	corneas	1243:1249	arg1	present					1232:1238	present	1232:1238	present	1232:1238	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	8	3	from	corneas	1243:1249	arg1	damage					1215:1220	the damage	1211:1220	the damage	1211:1220	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	8	4	theme	%	1290:1290	arg1	%					1297:1297	87.0% ± 4.5%	1286:1297	87.0% ± 4.5%	1286:1297	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	9	5	theme	proteomics	1309:1318	arg1	analysis					1320:1327	Further proteomics analysis	1301:1327	Further proteomics analysis	1301:1327	Further proteomics analysis revealed that corneal wound healing may be promoted by the ERK/MAPK and PI3K/AKT signal pathways.
34623206	1	6	theme	inflammations	246:258	arg1	risk					206:209	the risk	202:209	the risk of blinding corneal infections and inflammations	202:258	Corneal wound healing is a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations.
34623206	0	7	theme	corneal	81:87	arg1	healing					95:101	corneal wound healing	81:101	corneal wound healing	81:101	Gelatin hydrogel/contact lens composites as rutin delivery systems for promoting corneal wound healing.
34623206	10	8	theme	potential	1450:1458	arg1	strategy					1473:1480	a potential intervention strategy	1448:1480	a potential intervention strategy to facilitate corneal wound healing in humans	1448:1526	These results inform a potential intervention strategy to facilitate corneal wound healing in humans.
34623206	7	9	theme	corneal	1030:1036	arg1	injury					1038:1043	the corneal injury	1026:1043	the corneal injury	1026:1043	Finally, the effect of rutin-encapsulated composites on the healing of the corneal injury in rabbits was investigated.
34623206	4	10	theme	gelatin	574:580	arg1	composites					604:613	rutin-encapsulated gelatin hydrogel/contact lens composites	555:613	rutin-encapsulated gelatin hydrogel/contact lens composites	555:613	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	3	11	theme	low	354:356	arg1	bioavailability					358:372	its low bioavailability	350:372	its low bioavailability	350:372	However, its low bioavailability required a high therapeutic concentration, which can lead to ocular or even systemic side effects.
34623206	4	12	theme	effective	495:503	arg1	method					505:510	a safe and effective method	484:510	a safe and effective method for treating corneal injury	484:538	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	7	13	theme	injury	1038:1043	arg1	healing					1015:1021	the healing	1011:1021	the healing of the corneal injury in rabbits	1011:1054	Finally, the effect of rutin-encapsulated composites on the healing of the corneal injury in rabbits was investigated.
34623206	2	14	theme	main	290:293	arg1	drop					277:280	Traditional eye drop	261:280	Traditional eye drop	261:280	Traditional eye drop was the main approach for promoting corneal wound healing.
34623206	2	14	theme	main	290:293	arg1	approach					295:302	the main approach	286:302	the main approach for promoting corneal wound healing	286:338	Traditional eye drop was the main approach for promoting corneal wound healing.
34623206	8	15	dep	rate	1280:1283	arg1	%					1297:1297	87.0% ± 4.5%	1286:1297	87.0% ± 4.5%	1286:1297	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	5	16	dep	In	760:761	arg1	vitro					763:767	vitro	763:767	vitro	763:767	In vitro drug release results evidenced that rutin in the composites could be sustainedly released for up to 14 days.
34623206	5	17	theme	drug	769:772	arg1	release					774:780	In vitro drug release	760:780	In vitro drug release	760:780	In vitro drug release results evidenced that rutin in the composites could be sustainedly released for up to 14 days.
34623206	8	18	attach	present	1232:1238	arg2	damage					1215:1220	the damage	1211:1220	the damage	1211:1220	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	8	18	attach	present	1232:1238	arg1	corneas					1243:1249	corneas	1243:1249	corneas using the composite (healing rate, 87.0% ± 4.5%)	1243:1298	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	8	18	attach	present	1232:1238	arg2	present					1232:1238	present	1232:1238	present	1232:1238	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	4	19	theme	lens	599:602	arg1	composites					604:613	rutin-encapsulated gelatin hydrogel/contact lens composites	555:613	rutin-encapsulated gelatin hydrogel/contact lens composites	555:613	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	8	20	theme	rutin-encapsulated	1122:1139	arg1	composites					1141:1150	rutin-encapsulated composites	1122:1150	rutin-encapsulated composites (healing rate, 98.3% ± 0.7%)	1122:1179	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	8	20	theme	rutin-encapsulated	1122:1139	arg1	rate					1161:1164	healing rate	1153:1164	healing rate	1153:1164	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	3	21	theme	ocular	435:440	arg1	effects					464:470	ocular or even systemic side effects	435:470	ocular or even systemic side effects	435:470	However, its low bioavailability required a high therapeutic concentration, which can lead to ocular or even systemic side effects.
34623206	9	22	theme	Further	1301:1307	arg1	analysis					1320:1327	Further proteomics analysis	1301:1327	Further proteomics analysis	1301:1327	Further proteomics analysis revealed that corneal wound healing may be promoted by the ERK/MAPK and PI3K/AKT signal pathways.
34623206	4	23	theme	hydrogel/contact	582:597	arg1	composites					604:613	rutin-encapsulated gelatin hydrogel/contact lens composites	555:613	rutin-encapsulated gelatin hydrogel/contact lens composites	555:613	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	4	24	theme	radical	669:675	arg1	polymerization					677:690	in situ free radical polymerization	656:690	in situ free radical polymerization	656:690	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	3	25	theme	high	385:388	arg1	concentration					402:414	a high therapeutic concentration	383:414	a high therapeutic concentration	383:414	However, its low bioavailability required a high therapeutic concentration, which can lead to ocular or even systemic side effects.
34623206	6	26	theme	composites	943:952	arg1	nontoxicity					924:934	nontoxicity	924:934	nontoxicity of the composites	924:952	In addition, biocompatibility assay indicated nontoxicity of the composites.
34623206	9	27	theme	corneal	1343:1349	arg1	healing					1357:1363	corneal wound healing	1343:1363	corneal wound healing	1343:1363	Further proteomics analysis revealed that corneal wound healing may be promoted by the ERK/MAPK and PI3K/AKT signal pathways.
34623206	2	28	theme	corneal	318:324	arg1	healing					332:338	corneal wound healing	318:338	corneal wound healing	318:338	Traditional eye drop was the main approach for promoting corneal wound healing.
34623206	4	29	theme	carboxymethyl	696:708	arg1	crosslinking					746:757	carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking	696:757	carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking	696:757	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	3	30	theme	therapeutic	390:400	arg1	concentration					402:414	a high therapeutic concentration	383:414	a high therapeutic concentration	383:414	However, its low bioavailability required a high therapeutic concentration, which can lead to ocular or even systemic side effects.
34623206	7	31	from	healing	1015:1021	arg1	rabbits					1048:1054	rabbits	1048:1054	rabbits	1048:1054	Finally, the effect of rutin-encapsulated composites on the healing of the corneal injury in rabbits was investigated.
34623206	7	32	theme	composites	997:1006	arg1	effect					968:973	the effect	964:973	the effect of rutin-encapsulated composites on the healing of the corneal injury in rabbits	964:1054	Finally, the effect of rutin-encapsulated composites on the healing of the corneal injury in rabbits was investigated.
34623206	7	33	from	effect	968:973	arg1	healing					1015:1021	the healing	1011:1021	the healing of the corneal injury in rabbits	1011:1054	Finally, the effect of rutin-encapsulated composites on the healing of the corneal injury in rabbits was investigated.
34623206	9	34	theme	wound	1351:1355	arg1	healing					1357:1363	corneal wound healing	1343:1363	corneal wound healing	1343:1363	Further proteomics analysis revealed that corneal wound healing may be promoted by the ERK/MAPK and PI3K/AKT signal pathways.
34623206	10	35	from	healing	1510:1516	arg1	humans					1521:1526	humans	1521:1526	humans	1521:1526	These results inform a potential intervention strategy to facilitate corneal wound healing in humans.
34623206	1	36	theme	Corneal	104:110	arg1	healing					118:124	Corneal wound healing	104:124	Corneal wound healing	104:124	Corneal wound healing is a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations.
34623206	1	36	theme	Corneal	104:110	arg1	process					159:165	a highly regulated biological process	129:165	a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations	129:258	Corneal wound healing is a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations.
34623206	3	37	theme	side	459:462	arg1	effects					464:470	ocular or even systemic side effects	435:470	ocular or even systemic side effects	435:470	However, its low bioavailability required a high therapeutic concentration, which can lead to ocular or even systemic side effects.
34623206	0	38	theme	lens	25:28	arg1	composites					30:39	lens composites	25:39	lens composites	25:39	Gelatin hydrogel/contact lens composites as rutin delivery systems for promoting corneal wound healing.
34623206	0	38	theme	lens	25:28	arg1	systems					59:65	rutin delivery systems	44:65	rutin delivery systems for promoting corneal wound healing	44:101	Gelatin hydrogel/contact lens composites as rutin delivery systems for promoting corneal wound healing.
34623206	4	39	theme	rutin-encapsulated	555:572	arg1	composites					604:613	rutin-encapsulated gelatin hydrogel/contact lens composites	555:613	rutin-encapsulated gelatin hydrogel/contact lens composites	555:613	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	4	40	theme	dual	618:621	arg1	polymerization					677:690	in situ free radical polymerization	656:690	in situ free radical polymerization	656:690	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	4	40	theme	dual	618:621	arg1	crosslinking					746:757	carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking	696:757	carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking	696:757	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	4	40	theme	dual	618:621	arg1	reactions					636:644	dual crosslinking reactions	618:644	dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking	618:757	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	5	41	from	rutin	805:809	arg1	composites					818:827	the composites	814:827	the composites	814:827	In vitro drug release results evidenced that rutin in the composites could be sustainedly released for up to 14 days.
34623206	1	42	theme	wound	112:116	arg1	healing					118:124	Corneal wound healing	104:124	Corneal wound healing	104:124	Corneal wound healing is a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations.
34623206	1	42	theme	wound	112:116	arg1	process					159:165	a highly regulated biological process	129:165	a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations	129:258	Corneal wound healing is a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations.
34623206	8	43	from	present	1232:1238	arg1	corneas					1243:1249	corneas	1243:1249	corneas using the composite (healing rate, 87.0% ± 4.5%)	1243:1298	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	0	44	theme	rutin	44:48	arg1	composites					30:39	lens composites	25:39	lens composites	25:39	Gelatin hydrogel/contact lens composites as rutin delivery systems for promoting corneal wound healing.
34623206	0	44	theme	rutin	44:48	arg1	systems					59:65	rutin delivery systems	44:65	rutin delivery systems for promoting corneal wound healing	44:101	Gelatin hydrogel/contact lens composites as rutin delivery systems for promoting corneal wound healing.
34623206	4	45	theme	free	664:667	arg1	polymerization					677:690	in situ free radical polymerization	656:690	in situ free radical polymerization	656:690	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	8	46	theme	healing	1153:1159	arg1	composites					1141:1150	rutin-encapsulated composites	1122:1150	rutin-encapsulated composites (healing rate, 98.3% ± 0.7%)	1122:1179	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	8	46	theme	healing	1153:1159	arg1	rate					1161:1164	healing rate	1153:1164	healing rate	1153:1164	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	3	47	theme	even	445:448	arg1	effects					464:470	ocular or even systemic side effects	435:470	ocular or even systemic side effects	435:470	However, its low bioavailability required a high therapeutic concentration, which can lead to ocular or even systemic side effects.
34623206	8	48	theme	healing	1272:1278	arg1	rate					1280:1283	healing rate	1272:1283	healing rate	1272:1283	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	8	48	theme	healing	1272:1278	arg1	composite					1261:1269	the composite	1257:1269	the composite (healing rate, 87.0% ± 4.5%)	1257:1298	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	10	49	theme	wound	1504:1508	arg1	healing					1510:1516	corneal wound healing	1496:1516	corneal wound healing in humans	1496:1526	These results inform a potential intervention strategy to facilitate corneal wound healing in humans.
34623206	8	50	theme	48 h	1184:1187	arg1	post-operation					1189:1202	48 h post-operation	1184:1202	48 h post-operation	1184:1202	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	9	51	theme	PI3K/AKT	1401:1408	arg1	pathways					1417:1424	the ERK/MAPK and PI3K/AKT signal pathways	1384:1424	pathways	1417:1424	Further proteomics analysis revealed that corneal wound healing may be promoted by the ERK/MAPK and PI3K/AKT signal pathways.
34623206	3	52	theme	systemic	450:457	arg1	effects					464:470	ocular or even systemic side effects	435:470	ocular or even systemic side effects	435:470	However, its low bioavailability required a high therapeutic concentration, which can lead to ocular or even systemic side effects.
34623206	8	53	dep	rate	1161:1164	arg1	%					1178:1178	98.3% ± 0.7%	1167:1178	98.3% ± 0.7%	1167:1178	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	8	54	theme	±	1173:1173	arg1	%					1178:1178	98.3% ± 0.7%	1167:1178	98.3% ± 0.7%	1167:1178	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	4	55	dep	in	656:657	arg1	situ					659:662	situ	659:662	situ	659:662	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	0	56	theme	delivery	50:57	arg1	composites					30:39	lens composites	25:39	lens composites	25:39	Gelatin hydrogel/contact lens composites as rutin delivery systems for promoting corneal wound healing.
34623206	0	56	theme	delivery	50:57	arg1	systems					59:65	rutin delivery systems	44:65	rutin delivery systems for promoting corneal wound healing	44:101	Gelatin hydrogel/contact lens composites as rutin delivery systems for promoting corneal wound healing.
34623206	8	57	located	present	1232:1238	arg2	damage					1215:1220	the damage	1211:1220	the damage	1211:1220	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	8	57	located	present	1232:1238	arg1	corneas					1243:1249	corneas	1243:1249	corneas using the composite (healing rate, 87.0% ± 4.5%)	1243:1298	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	8	57	located	present	1232:1238	arg2	present					1232:1238	present	1232:1238	present	1232:1238	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	8	58	theme	%	1171:1171	arg1	%					1178:1178	98.3% ± 0.7%	1167:1178	98.3% ± 0.7%	1167:1178	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	4	59	theme	corneal	525:531	arg1	injury					533:538	corneal injury	525:538	corneal injury	525:538	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	6	60	theme	biocompatibility	891:906	arg1	assay					908:912	biocompatibility assay	891:912	biocompatibility assay	891:912	In addition, biocompatibility assay indicated nontoxicity of the composites.
34623206	2	61	theme	eye	273:275	arg1	drop					277:280	Traditional eye drop	261:280	Traditional eye drop	261:280	Traditional eye drop was the main approach for promoting corneal wound healing.
34623206	2	61	theme	eye	273:275	arg1	approach					295:302	the main approach	286:302	the main approach for promoting corneal wound healing	286:338	Traditional eye drop was the main approach for promoting corneal wound healing.
34623206	4	62	theme	cellulose/N-hydroxysulfosuccinimide	710:744	arg1	crosslinking					746:757	carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking	696:757	carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking	696:757	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	7	63	theme	rutin-encapsulated	978:995	arg1	composites					997:1006	rutin-encapsulated composites	978:1006	rutin-encapsulated composites	978:1006	Finally, the effect of rutin-encapsulated composites on the healing of the corneal injury in rabbits was investigated.
34623206	1	64	theme	blinding	214:221	arg1	infections					231:240	blinding corneal infections	214:240	blinding corneal infections	214:240	Corneal wound healing is a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations.
34623206	5	65	theme	In	760:761	arg1	release					774:780	In vitro drug release	760:780	In vitro drug release	760:780	In vitro drug release results evidenced that rutin in the composites could be sustainedly released for up to 14 days.
34623206	2	66	theme	Traditional	261:271	arg1	drop					277:280	Traditional eye drop	261:280	Traditional eye drop	261:280	Traditional eye drop was the main approach for promoting corneal wound healing.
34623206	2	66	theme	Traditional	261:271	arg1	approach					295:302	the main approach	286:302	the main approach for promoting corneal wound healing	286:338	Traditional eye drop was the main approach for promoting corneal wound healing.
34623206	10	67	theme	corneal	1496:1502	arg1	healing					1510:1516	corneal wound healing	1496:1516	corneal wound healing in humans	1496:1526	These results inform a potential intervention strategy to facilitate corneal wound healing in humans.
34623206	2	68	theme	wound	326:330	arg1	healing					332:338	corneal wound healing	318:338	corneal wound healing	318:338	Traditional eye drop was the main approach for promoting corneal wound healing.
34623206	1	69	theme	corneal	223:229	arg1	infections					231:240	blinding corneal infections	214:240	blinding corneal infections	214:240	Corneal wound healing is a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations.
34623206	8	70	theme	±	1292:1292	arg1	%					1297:1297	87.0% ± 4.5%	1286:1297	87.0% ± 4.5%	1286:1297	The injury was basically cured in corneas using rutin-encapsulated composites (healing rate, 98.3% ± 0.7%) at 48 h post-operation, while the damage was still present in corneas using the composite (healing rate, 87.0% ± 4.5%).
34623206	4	71	theme	in	656:657	arg1	polymerization					677:690	in situ free radical polymerization	656:690	in situ free radical polymerization	656:690	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	1	72	theme	regulated	138:146	arg1	healing					118:124	Corneal wound healing	104:124	Corneal wound healing	104:124	Corneal wound healing is a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations.
34623206	1	72	theme	regulated	138:146	arg1	process					159:165	a highly regulated biological process	129:165	a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations	129:258	Corneal wound healing is a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations.
34623206	1	73	theme	infections	231:240	arg1	risk					206:209	the risk	202:209	the risk of blinding corneal infections and inflammations	202:258	Corneal wound healing is a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations.
34623206	5	74	dep	results	782:788	arg1	evidenced					790:798	evidenced	790:798	results evidenced that rutin in the composites could be sustainedly released for up to 14 days	782:875	In vitro drug release results evidenced that rutin in the composites could be sustainedly released for up to 14 days.
34623206	9	75	theme	signal	1410:1415	arg1	pathways					1417:1424	the ERK/MAPK and PI3K/AKT signal pathways	1384:1424	pathways	1417:1424	Further proteomics analysis revealed that corneal wound healing may be promoted by the ERK/MAPK and PI3K/AKT signal pathways.
34623206	1	76	theme	biological	148:157	arg1	healing					118:124	Corneal wound healing	104:124	Corneal wound healing	104:124	Corneal wound healing is a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations.
34623206	1	76	theme	biological	148:157	arg1	process					159:165	a highly regulated biological process	129:165	a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations	129:258	Corneal wound healing is a highly regulated biological process that is of importance for reducing the risk of blinding corneal infections and inflammations.
34623206	4	77	theme	crosslinking	623:634	arg1	polymerization					677:690	in situ free radical polymerization	656:690	in situ free radical polymerization	656:690	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	4	77	theme	crosslinking	623:634	arg1	crosslinking					746:757	carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking	696:757	carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking	696:757	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
34623206	4	77	theme	crosslinking	623:634	arg1	reactions					636:644	dual crosslinking reactions	618:644	dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking	618:757	To develop a safe and effective method for treating corneal injury, we fabricated rutin-encapsulated gelatin hydrogel/contact lens composites by dual crosslinking reactions including in situ free radical polymerization and carboxymethyl cellulose/N-hydroxysulfosuccinimide crosslinking.
32006584	7	0	theme	dairy	1097:1101	arg1	foods					1103:1107	dairy foods	1097:1107	dairy foods	1097:1107	β-D-Galactosidase immobilized in pectin-based hydrogels could be applied in the hydrolysis of lactose contained in either dairy foods or lactose-intolerant individuals.
32006584	2	1	theme	X-ray	412:416	arg1	diffraction					418:428	X-ray diffraction	412:428	X-ray diffraction	412:428	These hydrogels were synthesized via chemical crosslinking, and characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, thermal analysis, mechanical assays, X-ray diffraction, and swelling kinetics.
32006584	4	2	theme	residue	641:647	arg1	%					630:630	0, 5 and 10%	619:630	0, 5 and 10% of pinus residue	619:647	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	4	2	theme	residue	641:647	arg1	residue					641:647	pinus residue	635:647	pinus residue	635:647	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	4	3	theme	hydrogels	598:606	arg1	242.08 ± 0.36					667:679	242.08 ± 0.36	667:679	242.08 ± 0.36	667:679	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	4	3	theme	hydrogels	598:606	arg1	capacities					580:589	The β-D-galactosidase immobilization capacities	543:589	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue	543:647	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	4	4	theme	pinus	635:639	arg1	residue					641:647	pinus residue	635:647	pinus residue	635:647	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	3	5	from	mechanism	475:483	arg1	networks					501:508	the hydrogel networks	488:508	the hydrogel networks	488:508	The water absorption mechanism in the hydrogel networks occurs by non-Fickian transport.
32006584	2	6	theme	scanning	345:352	arg1	microscopy					363:372	scanning electron microscopy	345:372	scanning electron microscopy	345:372	These hydrogels were synthesized via chemical crosslinking, and characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, thermal analysis, mechanical assays, X-ray diffraction, and swelling kinetics.
32006584	4	7	from	pH 4.0	749:754	arg1	capacities					580:589	The β-D-galactosidase immobilization capacities	543:589	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue	543:647	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	4	7	from	pH 4.0	749:754	arg1	242.08 ± 0.36					667:679	242.08 ± 0.36	667:679	242.08 ± 0.36	667:679	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	5	8	from	pH 5.6	865:870	arg1	182.99 ± 0.41					793:805	182.99 ± 0.41	793:805	182.99 ± 0.41	793:805	These values were 182.99 ± 0.41, 219.99 ± 0.47 and 218.56 ± 0.39 mg g-1, respectively, at pH 5.6.
32006584	7	9	theme	lactose	1069:1075	arg1	hydrolysis					1055:1064	the hydrolysis	1051:1064	the hydrolysis of lactose contained in either dairy foods or lactose-intolerant individuals	1051:1141	β-D-Galactosidase immobilized in pectin-based hydrogels could be applied in the hydrolysis of lactose contained in either dairy foods or lactose-intolerant individuals.
32006584	4	10	contain	containing	608:617	arg2	%					630:630	0, 5 and 10%	619:630	0, 5 and 10% of pinus residue	619:647	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	4	10	contain	containing	608:617	arg2	residue					641:647	pinus residue	635:647	pinus residue	635:647	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	4	10	contain	containing	608:617	arg1	hydrogels					598:606	the hydrogels	594:606	the hydrogels containing 0, 5 and 10% of pinus residue	594:647	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	1	11	theme	β-D-galactosidase	204:220	arg1	immobilization					186:199	the immobilization	182:199	the immobilization of β-D-galactosidase	182:220	The aim of this work was to synthesize pinus residue/pectin-based composite hydrogels for the immobilization of β-D-galactosidase.
32006584	3	12	theme	hydrogel	492:499	arg1	networks					501:508	the hydrogel networks	488:508	the hydrogel networks	488:508	The water absorption mechanism in the hydrogel networks occurs by non-Fickian transport.
32006584	4	13	theme	immobilization	565:578	arg1	242.08 ± 0.36					667:679	242.08 ± 0.36	667:679	242.08 ± 0.36	667:679	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	4	13	theme	immobilization	565:578	arg1	capacities					580:589	The β-D-galactosidase immobilization capacities	543:589	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue	543:647	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	6	14	theme	Pectin-based	873:884	arg1	hydrogels					886:894	Pectin-based hydrogels	873:894	Pectin-based hydrogels	873:894	Pectin-based hydrogels demonstrated to be excellent solid supports for the immobilization of enzymes.
32006584	2	15	theme	infrared	322:329	arg1	spectroscopy					331:342	Fourier-transform infrared spectroscopy	304:342	Fourier-transform infrared spectroscopy	304:342	These hydrogels were synthesized via chemical crosslinking, and characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, thermal analysis, mechanical assays, X-ray diffraction, and swelling kinetics.
32006584	4	16	theme	dried	730:734	arg1	hydrogel					736:743	g dried hydrogel	728:743	g dried hydrogel	728:743	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	4	17	theme	β-D-galactosidase	547:563	arg1	242.08 ± 0.36					667:679	242.08 ± 0.36	667:679	242.08 ± 0.36	667:679	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	4	17	theme	β-D-galactosidase	547:563	arg1	capacities					580:589	The β-D-galactosidase immobilization capacities	543:589	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue	543:647	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	2	18	theme	thermal	375:381	arg1	analysis					383:390	thermal analysis	375:390	thermal analysis	375:390	These hydrogels were synthesized via chemical crosslinking, and characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, thermal analysis, mechanical assays, X-ray diffraction, and swelling kinetics.
32006584	2	19	theme	swelling	435:442	arg1	kinetics					444:451	swelling kinetics	435:451	swelling kinetics	435:451	These hydrogels were synthesized via chemical crosslinking, and characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, thermal analysis, mechanical assays, X-ray diffraction, and swelling kinetics.
32006584	6	20	dep	solid	925:929	arg1	supports					931:938	supports	931:938	supports	931:938	Pectin-based hydrogels demonstrated to be excellent solid supports for the immobilization of enzymes.
32006584	1	21	theme	work	108:111	arg1	aim					96:98	The aim	92:98	The aim of this work	92:111	The aim of this work was to synthesize pinus residue/pectin-based composite hydrogels for the immobilization of β-D-galactosidase.
32006584	3	22	theme	non-Fickian	520:530	arg1	transport					532:540	non-Fickian transport	520:540	non-Fickian transport	520:540	The water absorption mechanism in the hydrogel networks occurs by non-Fickian transport.
32006584	0	23	theme	composite	27:35	arg1	hydrogels					37:45	composite hydrogels	27:45	composite hydrogels for the immobilization of β-D-galactosidase	27:89	Pinus residue/pectin-based composite hydrogels for the immobilization of β-D-galactosidase.
32006584	6	24	theme	enzymes	966:972	arg1	immobilization					948:961	the immobilization	944:961	the immobilization of enzymes	944:972	Pectin-based hydrogels demonstrated to be excellent solid supports for the immobilization of enzymes.
32006584	2	25	theme	electron	354:361	arg1	microscopy					363:372	scanning electron microscopy	345:372	scanning electron microscopy	345:372	These hydrogels were synthesized via chemical crosslinking, and characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, thermal analysis, mechanical assays, X-ray diffraction, and swelling kinetics.
32006584	4	26	theme	182.71 ± 0.36 mg	700:715	arg1	enzyme					717:722	182.71 ± 0.36 mg enzyme	700:722	182.71 ± 0.36 mg enzyme	700:722	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	3	27	theme	absorption	464:473	arg1	mechanism					475:483	The water absorption mechanism	454:483	The water absorption mechanism in the hydrogel networks	454:508	The water absorption mechanism in the hydrogel networks occurs by non-Fickian transport.
32006584	4	28	theme	g	728:728	arg1	hydrogel					736:743	g dried hydrogel	728:743	g dried hydrogel	728:743	The β-D-galactosidase immobilization capacities of the hydrogels containing 0, 5 and 10% of pinus residue were respectively 242.08 ± 0.36, 181.27 ± 0.50 and 182.71 ± 0.36 mg enzyme per g dried hydrogel, at pH 4.0 and after 600 min.
32006584	2	29	theme	chemical	260:267	arg1	crosslinking					269:280	chemical crosslinking	260:280	chemical crosslinking	260:280	These hydrogels were synthesized via chemical crosslinking, and characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, thermal analysis, mechanical assays, X-ray diffraction, and swelling kinetics.
32006584	3	30	theme	water	458:462	arg1	mechanism					475:483	The water absorption mechanism	454:483	The water absorption mechanism in the hydrogel networks	454:508	The water absorption mechanism in the hydrogel networks occurs by non-Fickian transport.
32006584	7	31	theme	lactose-intolerant	1112:1129	arg1	individuals					1131:1141	lactose-intolerant individuals	1112:1141	lactose-intolerant individuals	1112:1141	β-D-Galactosidase immobilized in pectin-based hydrogels could be applied in the hydrolysis of lactose contained in either dairy foods or lactose-intolerant individuals.
32006584	2	32	theme	mechanical	393:402	arg1	assays					404:409	mechanical assays	393:409	mechanical assays	393:409	These hydrogels were synthesized via chemical crosslinking, and characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, thermal analysis, mechanical assays, X-ray diffraction, and swelling kinetics.
32006584	2	33	theme	Fourier-transform	304:320	arg1	spectroscopy					331:342	Fourier-transform infrared spectroscopy	304:342	Fourier-transform infrared spectroscopy	304:342	These hydrogels were synthesized via chemical crosslinking, and characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, thermal analysis, mechanical assays, X-ray diffraction, and swelling kinetics.
32006584	1	34	theme	pinus	131:135	arg1	hydrogels					168:176	pinus residue/pectin-based composite hydrogels	131:176	pinus residue/pectin-based composite hydrogels for the immobilization of β-D-galactosidase	131:220	The aim of this work was to synthesize pinus residue/pectin-based composite hydrogels for the immobilization of β-D-galactosidase.
32006584	1	35	theme	residue/pectin-based	137:156	arg1	hydrogels					168:176	pinus residue/pectin-based composite hydrogels	131:176	pinus residue/pectin-based composite hydrogels for the immobilization of β-D-galactosidase	131:220	The aim of this work was to synthesize pinus residue/pectin-based composite hydrogels for the immobilization of β-D-galactosidase.
32006584	7	36	theme	pectin-based	1008:1019	arg1	hydrogels					1021:1029	pectin-based hydrogels	1008:1029	pectin-based hydrogels	1008:1029	β-D-Galactosidase immobilized in pectin-based hydrogels could be applied in the hydrolysis of lactose contained in either dairy foods or lactose-intolerant individuals.
32006584	1	37	theme	composite	158:166	arg1	hydrogels					168:176	pinus residue/pectin-based composite hydrogels	131:176	pinus residue/pectin-based composite hydrogels for the immobilization of β-D-galactosidase	131:220	The aim of this work was to synthesize pinus residue/pectin-based composite hydrogels for the immobilization of β-D-galactosidase.
32006584	0	38	theme	β-D-galactosidase	73:89	arg1	immobilization					55:68	the immobilization	51:68	the immobilization of β-D-galactosidase	51:89	Pinus residue/pectin-based composite hydrogels for the immobilization of β-D-galactosidase.
34800840	0	0	theme	ultrasound	112:121	arg1	treatment					123:131	ultrasound treatment	112:131	ultrasound treatment	112:131	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	5	1	theme	storage	1115:1121	arg1	time					1123:1126	storage time	1115:1126	storage time	1115:1126	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	2	2	theme	ultrasonic	590:599	arg1	frequency					601:609	ultrasonic frequency	590:609	ultrasonic frequency	590:609	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	7	3	from	loading	1477:1483	arg1	substances					1519:1528	bioactive substances	1509:1528	bioactive substances	1509:1528	The above results indicate that ultrasound not only increases the loading of the nanoparticles on bioactive substances but also improves the environmental stability and antioxidant activity of the formed nanoparticles.
34800840	3	4	theme	driving	797:803	arg1	interactions					770:781	hydrophobic interactions	758:781	hydrophobic interactions	758:781	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	4	theme	driving	797:803	arg1	interactions					722:733	Electrostatic interactions	708:733	Electrostatic interactions	708:733	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	4	theme	driving	797:803	arg1	bonding					745:751	hydrogen bonding	736:751	hydrogen bonding	736:751	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	4	theme	driving	797:803	arg1	forces					805:810	the main driving forces	788:810	the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment	788:889	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	2	5	theme	encapsulation	487:499	arg1	efficiency					501:510	encapsulation efficiency	487:510	encapsulation efficiency of Qu (78.55%, increased by 22.12%)	487:546	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	6	6	theme	ternary	1295:1301	arg1	nanoparticles					1303:1315	the ternary nanoparticles	1291:1315	the ternary nanoparticles prepared by ultrasound	1291:1338	Furthermore, the ternary nanoparticles prepared by ultrasound exhibited excellent stability in simulated gastrointestinal digestion.
34800840	1	7	theme	-loaded	296:302	arg1	CPP					328:330	CPP	328:330	CPP	328:330	Ultrasound treatment was used to successfully prepare Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles.
34800840	1	7	theme	-loaded	296:302	arg1	phosphopeptides					311:325	Quercetin (Qu)-loaded Casein phosphopeptides	282:325	Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles	282:359	Ultrasound treatment was used to successfully prepare Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles.
34800840	4	8	theme	composite	931:939	arg1	nanoparticles					941:953	The compact, homogeneous and spherical composite nanoparticles	892:953	The compact, homogeneous and spherical composite nanoparticles obtained by sonication	892:976	The compact, homogeneous and spherical composite nanoparticles obtained by sonication were clearly observed by scanning electron microscope and atomic force microscope.
34800840	7	9	theme	nanoparticles	1492:1504	arg1	loading					1477:1483	the loading	1473:1483	the loading of the nanoparticles on bioactive substances	1473:1528	The above results indicate that ultrasound not only increases the loading of the nanoparticles on bioactive substances but also improves the environmental stability and antioxidant activity of the formed nanoparticles.
34800840	7	10	theme	above	1415:1419	arg1	results					1421:1427	The above results	1411:1427	The above results	1411:1427	The above results indicate that ultrasound not only increases the loading of the nanoparticles on bioactive substances but also improves the environmental stability and antioxidant activity of the formed nanoparticles.
34800840	0	11	dep	loaded	46:51	arg1	mechanism					165:173	formation mechanism	155:173	formation mechanism	155:173	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	0	11	dep	loaded	46:51	arg1	stability					192:200	physicochemical stability	176:200	physicochemical stability	176:200	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	0	11	dep	loaded	46:51	arg1	activity					218:225	antioxidant activity	206:225	antioxidant activity	206:225	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	0	11	dep	loaded	46:51	arg1	optimization					141:152	Factor optimization	134:152	Factor optimization	134:152	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	1	12	theme	Casein	304:309	arg1	CPP					328:330	CPP	328:330	CPP	328:330	Ultrasound treatment was used to successfully prepare Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles.
34800840	1	12	theme	Casein	304:309	arg1	phosphopeptides					311:325	Quercetin (Qu)-loaded Casein phosphopeptides	282:325	Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles	282:359	Ultrasound treatment was used to successfully prepare Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles.
34800840	2	13	dep	increased	527:535	arg1	%					524:524	78.55%	519:524	78.55%	519:524	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	7	14	theme	bioactive	1509:1517	arg1	substances					1519:1528	bioactive substances	1509:1528	bioactive substances	1509:1528	The above results indicate that ultrasound not only increases the loading of the nanoparticles on bioactive substances but also improves the environmental stability and antioxidant activity of the formed nanoparticles.
34800840	2	15	theme	following	568:576	arg1	conditions					578:587	following conditions	568:587	following conditions	568:587	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	2	16	theme	power	630:634	arg1	density					636:642	the power density	626:642	the power density	626:642	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	2	16	theme	power	630:634	arg1	80 W/L					645:650	80 W/L	645:650	80 W/L	645:650	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	1	17	theme	phosphopeptides	311:325	arg1	CS					343:344	CS	343:344	CS	343:344	Ultrasound treatment was used to successfully prepare Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles.
34800840	1	17	theme	phosphopeptides	311:325	arg1	/chitosan					332:340	Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan	282:340	Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles	282:359	Ultrasound treatment was used to successfully prepare Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles.
34800840	7	18	dep	stability	1566:1574	arg1	the					1548:1550	the	1548:1550	the	1548:1550	The above results indicate that ultrasound not only increases the loading of the nanoparticles on bioactive substances but also improves the environmental stability and antioxidant activity of the formed nanoparticles.
34800840	2	19	dep	decreased	456:464	arg1	241.27 nm					445:453	241.27 nm	445:453	241.27 nm	445:453	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	5	20	theme	nanoparticles	1211:1223	arg1	stability					1079:1087	The environmental stability	1061:1087	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion)	1061:1169	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	5	20	theme	nanoparticles	1211:1223	arg1	activity					1187:1194	antioxidant activity	1175:1194	antioxidant activity	1175:1194	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	0	21	theme	Factor	134:139	arg1	optimization					141:152	Factor optimization	134:152	Factor optimization	134:152	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	5	22	theme	exposure	1100:1107	arg1	time					1109:1112	exposure time	1100:1112	exposure time	1100:1112	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	6	23	theme	gastrointestinal	1383:1398	arg1	digestion					1400:1408	simulated gastrointestinal digestion	1373:1408	simulated gastrointestinal digestion	1373:1408	Furthermore, the ternary nanoparticles prepared by ultrasound exhibited excellent stability in simulated gastrointestinal digestion.
34800840	3	24	theme	ultrasound	870:879	arg1	treatment					881:889	ultrasound treatment	870:889	ultrasound treatment	870:889	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	8	25	used	used	1726:1729	arg2	preparation					1650:1660	Ultrasound-assisted preparation	1630:1660	Ultrasound-assisted preparation of nanoparticles loaded with bioactive substances	1630:1710	Ultrasound-assisted preparation of nanoparticles loaded with bioactive substances could be well used in the functional food and beverage industry.
34800840	1	26	theme	Ultrasound	228:237	arg1	treatment					239:247	Ultrasound treatment	228:247	Ultrasound treatment	228:247	Ultrasound treatment was used to successfully prepare Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles.
34800840	3	27	theme	Electrostatic	708:720	arg1	interactions					770:781	hydrophobic interactions	758:781	hydrophobic interactions	758:781	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	27	theme	Electrostatic	708:720	arg1	interactions					722:733	Electrostatic interactions	708:733	Electrostatic interactions	708:733	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	27	theme	Electrostatic	708:720	arg1	bonding					745:751	hydrogen bonding	736:751	hydrogen bonding	736:751	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	27	theme	Electrostatic	708:720	arg1	forces					805:810	the main driving forces	788:810	the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment	788:889	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	4	28	theme	electron	1012:1019	arg1	microscope					1021:1030	scanning electron microscope	1003:1030	scanning electron microscope	1003:1030	The compact, homogeneous and spherical composite nanoparticles obtained by sonication were clearly observed by scanning electron microscope and atomic force microscope.
34800840	2	29	theme	ternary	399:405	arg1	nanoparticles					407:419	the above ternary nanoparticles	389:419	the above ternary nanoparticles	389:419	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	4	30	theme	force	1043:1047	arg1	microscope					1049:1058	atomic force microscope	1036:1058	atomic force microscope	1036:1058	The compact, homogeneous and spherical composite nanoparticles obtained by sonication were clearly observed by scanning electron microscope and atomic force microscope.
34800840	0	31	theme	formation	155:163	arg1	mechanism					165:173	formation mechanism	155:173	formation mechanism	155:173	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	3	32	theme	main	792:795	arg1	interactions					770:781	hydrophobic interactions	758:781	hydrophobic interactions	758:781	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	32	theme	main	792:795	arg1	interactions					722:733	Electrostatic interactions	708:733	Electrostatic interactions	708:733	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	32	theme	main	792:795	arg1	bonding					745:751	hydrogen bonding	736:751	hydrogen bonding	736:751	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	32	theme	main	792:795	arg1	forces					805:810	the main driving forces	788:810	the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment	788:889	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	4	33	theme	atomic	1036:1041	arg1	microscope					1049:1058	atomic force microscope	1036:1058	atomic force microscope	1036:1058	The compact, homogeneous and spherical composite nanoparticles obtained by sonication were clearly observed by scanning electron microscope and atomic force microscope.
34800840	5	34	theme	antioxidant	1175:1185	arg1	activity					1187:1194	antioxidant activity	1175:1194	antioxidant activity	1175:1194	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	4	35	theme	compact	896:902	arg1	nanoparticles					941:953	The compact, homogeneous and spherical composite nanoparticles	892:953	The compact, homogeneous and spherical composite nanoparticles obtained by sonication	892:976	The compact, homogeneous and spherical composite nanoparticles obtained by sonication were clearly observed by scanning electron microscope and atomic force microscope.
34800840	1	36	theme	/chitosan	332:340	arg1	nanoparticles					347:359	Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles	282:359	Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles	282:359	Ultrasound treatment was used to successfully prepare Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles.
34800840	4	37	theme	spherical	921:929	arg1	nanoparticles					941:953	The compact, homogeneous and spherical composite nanoparticles	892:953	The compact, homogeneous and spherical composite nanoparticles obtained by sonication	892:976	The compact, homogeneous and spherical composite nanoparticles obtained by sonication were clearly observed by scanning electron microscope and atomic force microscope.
34800840	7	38	theme	formed	1608:1613	arg1	nanoparticles					1615:1627	the formed nanoparticles	1604:1627	the formed nanoparticles	1604:1627	The above results indicate that ultrasound not only increases the loading of the nanoparticles on bioactive substances but also improves the environmental stability and antioxidant activity of the formed nanoparticles.
34800840	2	39	dep	size	439:442	arg1	decreased					456:464	decreased	456:464	decreased by 34.32%	456:474	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	0	40	theme	quercetin	36:44	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	0	40	theme	quercetin	36:44	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	4	41	theme	scanning	1003:1010	arg1	microscope					1021:1030	scanning electron microscope	1003:1030	scanning electron microscope	1003:1030	The compact, homogeneous and spherical composite nanoparticles obtained by sonication were clearly observed by scanning electron microscope and atomic force microscope.
34800840	4	42	theme	homogeneous	905:915	arg1	nanoparticles					941:953	The compact, homogeneous and spherical composite nanoparticles	892:953	The compact, homogeneous and spherical composite nanoparticles obtained by sonication	892:976	The compact, homogeneous and spherical composite nanoparticles obtained by sonication were clearly observed by scanning electron microscope and atomic force microscope.
34800840	6	43	theme	simulated	1373:1381	arg1	digestion					1400:1408	simulated gastrointestinal digestion	1373:1408	simulated gastrointestinal digestion	1373:1408	Furthermore, the ternary nanoparticles prepared by ultrasound exhibited excellent stability in simulated gastrointestinal digestion.
34800840	2	44	theme	smallest	430:437	arg1	size					439:442	the smallest size	426:442	the smallest size (241.27 nm, decreased by 34.32%)	426:475	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	0	45	theme	phosphopeptides-chitosan	60:83	arg1	nanoparticles					95:107	casein phosphopeptides-chitosan composite nanoparticles	53:107	casein phosphopeptides-chitosan composite nanoparticles	53:107	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	5	46	theme	simulated	1133:1141	arg1	digestion					1160:1168	simulated gastrointestinal digestion	1133:1168	simulated gastrointestinal digestion	1133:1168	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	1	47	used	used	253:256	arg2	treatment					239:247	Ultrasound treatment	228:247	Ultrasound treatment	228:247	Ultrasound treatment was used to successfully prepare Quercetin (Qu)-loaded Casein phosphopeptides (CPP)/chitosan (CS) nanoparticles.
34800840	2	48	dep	Qu	515:516	arg1	increased					527:535	increased	527:535	increased by 22.12%	527:545	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	7	49	theme	nanoparticles	1615:1627	arg1	stability					1566:1574	environmental stability	1552:1574	environmental stability	1552:1574	The above results indicate that ultrasound not only increases the loading of the nanoparticles on bioactive substances but also improves the environmental stability and antioxidant activity of the formed nanoparticles.
34800840	7	49	theme	nanoparticles	1615:1627	arg1	activity					1592:1599	antioxidant activity	1580:1599	antioxidant activity	1580:1599	The above results indicate that ultrasound not only increases the loading of the nanoparticles on bioactive substances but also improves the environmental stability and antioxidant activity of the formed nanoparticles.
34800840	0	50	theme	casein	53:58	arg1	nanoparticles					95:107	casein phosphopeptides-chitosan composite nanoparticles	53:107	casein phosphopeptides-chitosan composite nanoparticles	53:107	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	5	51	theme	gastrointestinal	1143:1158	arg1	digestion					1160:1168	simulated gastrointestinal digestion	1133:1168	simulated gastrointestinal digestion	1133:1168	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	0	52	theme	physicochemical	176:190	arg1	stability					192:200	physicochemical stability	176:200	physicochemical stability	176:200	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	8	53	theme	nanoparticles	1665:1677	arg1	preparation					1650:1660	Ultrasound-assisted preparation	1630:1660	Ultrasound-assisted preparation of nanoparticles loaded with bioactive substances	1630:1710	Ultrasound-assisted preparation of nanoparticles loaded with bioactive substances could be well used in the functional food and beverage industry.
34800840	8	54	theme	Ultrasound-assisted	1630:1648	arg1	preparation					1650:1660	Ultrasound-assisted preparation	1630:1660	Ultrasound-assisted preparation of nanoparticles loaded with bioactive substances	1630:1710	Ultrasound-assisted preparation of nanoparticles loaded with bioactive substances could be well used in the functional food and beverage industry.
34800840	8	55	theme	food	1749:1752	arg1	industry					1767:1774	the functional food and beverage industry	1734:1774	the functional food and beverage industry	1734:1774	Ultrasound-assisted preparation of nanoparticles loaded with bioactive substances could be well used in the functional food and beverage industry.
34800840	3	56	theme	hydrogen	736:743	arg1	interactions					770:781	hydrophobic interactions	758:781	hydrophobic interactions	758:781	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	56	theme	hydrogen	736:743	arg1	interactions					722:733	Electrostatic interactions	708:733	Electrostatic interactions	708:733	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	56	theme	hydrogen	736:743	arg1	bonding					745:751	hydrogen bonding	736:751	hydrogen bonding	736:751	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	56	theme	hydrogen	736:743	arg1	forces					805:810	the main driving forces	788:810	the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment	788:889	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	0	57	theme	antioxidant	206:216	arg1	activity					218:225	antioxidant activity	206:225	antioxidant activity	206:225	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	7	58	theme	antioxidant	1580:1590	arg1	activity					1592:1599	antioxidant activity	1580:1599	antioxidant activity	1580:1599	The above results indicate that ultrasound not only increases the loading of the nanoparticles on bioactive substances but also improves the environmental stability and antioxidant activity of the formed nanoparticles.
34800840	5	59	theme	ternary	1203:1209	arg1	nanoparticles					1211:1223	the ternary nanoparticles	1199:1223	the ternary nanoparticles	1199:1223	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	8	60	theme	functional	1738:1747	arg1	industry					1767:1774	the functional food and beverage industry	1734:1774	the functional food and beverage industry	1734:1774	Ultrasound-assisted preparation of nanoparticles loaded with bioactive substances could be well used in the functional food and beverage industry.
34800840	6	61	theme	excellent	1350:1358	arg1	stability					1360:1368	excellent stability	1350:1368	excellent stability	1350:1368	Furthermore, the ternary nanoparticles prepared by ultrasound exhibited excellent stability in simulated gastrointestinal digestion.
34800840	7	62	theme	environmental	1552:1564	arg1	stability					1566:1574	environmental stability	1552:1574	environmental stability	1552:1574	The above results indicate that ultrasound not only increases the loading of the nanoparticles on bioactive substances but also improves the environmental stability and antioxidant activity of the formed nanoparticles.
34800840	8	63	theme	beverage	1758:1765	arg1	industry					1767:1774	the functional food and beverage industry	1734:1774	the functional food and beverage industry	1734:1774	Ultrasound-assisted preparation of nanoparticles loaded with bioactive substances could be well used in the functional food and beverage industry.
34800840	8	64	theme	bioactive	1691:1699	arg1	substances					1701:1710	bioactive substances	1691:1710	bioactive substances	1691:1710	Ultrasound-assisted preparation of nanoparticles loaded with bioactive substances could be well used in the functional food and beverage industry.
34800840	2	65	theme	Qu	515:516	arg1	efficiency					501:510	encapsulation efficiency	487:510	encapsulation efficiency of Qu (78.55%, increased by 22.12%)	487:546	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	5	66	theme	environmental	1065:1077	arg1	stability					1079:1087	The environmental stability	1061:1087	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion)	1061:1169	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	2	67	theme	above	393:397	arg1	nanoparticles					407:419	the above ternary nanoparticles	389:419	the above ternary nanoparticles	389:419	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	3	68	theme	nanoparticles	816:828	arg1	formulation					830:840	nanoparticles formulation	816:840	nanoparticles formulation	816:840	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	5	69	dep	stability	1079:1087	arg1	time					1123:1126	storage time	1115:1126	storage time	1115:1126	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	5	69	dep	stability	1079:1087	arg1	pH					1096:1097	pH	1096:1097	pH	1096:1097	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	5	69	dep	stability	1079:1087	arg1	digestion					1160:1168	simulated gastrointestinal digestion	1133:1168	simulated gastrointestinal digestion	1133:1168	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	5	69	dep	stability	1079:1087	arg1	NaCl					1090:1093	NaCl	1090:1093	NaCl	1090:1093	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	5	69	dep	stability	1079:1087	arg1	time					1109:1112	exposure time	1100:1112	exposure time	1100:1112	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	0	70	theme	composite	85:93	arg1	nanoparticles					95:107	casein phosphopeptides-chitosan composite nanoparticles	53:107	casein phosphopeptides-chitosan composite nanoparticles	53:107	Fabrication and characterization of quercetin loaded casein phosphopeptides-chitosan composite nanoparticles by ultrasound treatment: Factor optimization, formation mechanism, physicochemical stability and antioxidant activity.
34800840	2	71	with	nanoparticles	407:419	arg1	size					439:442	the smallest size	426:442	the smallest size (241.27 nm, decreased by 34.32%)	426:475	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	2	72	theme	intermittent	679:690	arg1	20 s/5s					699:705	20 s/5s	699:705	20 s/5s	699:705	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	2	72	theme	intermittent	679:690	arg1	ratio					692:696	the intermittent ratio	675:696	the intermittent ratio	675:696	Compared with the control, the above ternary nanoparticles with the smallest size (241.27 nm, decreased by 34.32%), improved encapsulation efficiency of Qu (78.55%, increased by 22.12%) when prepared under following conditions: ultrasonic frequency, 20/35/50 kHz; the power density, 80 W/L; the time, 20 min, and the intermittent ratio, 20 s/5s.
34800840	5	73	theme	ultrasonic	1256:1265	arg1	treatment					1267:1275	ultrasonic treatment	1256:1275	ultrasonic treatment	1256:1275	The environmental stability (NaCl, pH, exposure time, storage time, and simulated gastrointestinal digestion) and antioxidant activity of the ternary nanoparticles were remarkably enhanced after ultrasonic treatment.
34800840	3	74	theme	hydrophobic	758:768	arg1	interactions					770:781	hydrophobic interactions	758:781	hydrophobic interactions	758:781	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	74	theme	hydrophobic	758:768	arg1	interactions					722:733	Electrostatic interactions	708:733	Electrostatic interactions	708:733	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	74	theme	hydrophobic	758:768	arg1	bonding					745:751	hydrogen bonding	736:751	hydrogen bonding	736:751	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
34800840	3	74	theme	hydrophobic	758:768	arg1	forces					805:810	the main driving forces	788:810	the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment	788:889	Electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for nanoparticles formulation, which were strengthened by ultrasound treatment.
32068059	3	0	theme	diffraction	510:520	arg1	pattern					522:528	The X-ray diffraction pattern	500:528	The X-ray diffraction pattern	500:528	The X-ray diffraction pattern showed that the crystallinity index of the alkali-treated CGFB fibers was fairly higher than raw fibers.
32068059	5	1	theme	Scanning	772:779	arg1	microscopy					790:799	Scanning electron microscopy	772:799	Scanning electron microscopy	772:799	Scanning electron microscopy and Atomic force microscopy images showed the partially roughened surface of the fiber due to the removal of non-cellulosic elements and surface impurities during alkali treatment.
32068059	0	2	theme	fruit	78:82	arg1	bunch					84:88	Calotropis gigantea fruit bunch	58:88	Calotropis gigantea fruit bunch for ecofriendly polymer composites	58:123	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.
32068059	5	3	theme	force	812:816	arg1	microscopy					818:827	Atomic force microscopy	805:827	Atomic force microscopy	805:827	Scanning electron microscopy and Atomic force microscopy images showed the partially roughened surface of the fiber due to the removal of non-cellulosic elements and surface impurities during alkali treatment.
32068059	5	4	theme	surface	938:944	arg1	impurities					946:955	surface impurities	938:955	surface impurities	938:955	Scanning electron microscopy and Atomic force microscopy images showed the partially roughened surface of the fiber due to the removal of non-cellulosic elements and surface impurities during alkali treatment.
32068059	0	5	theme	ecofriendly	94:104	arg1	composites					114:123	ecofriendly polymer composites	94:123	ecofriendly polymer composites	94:123	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.
32068059	0	6	from	Characterization	0:15	arg1	bunch					84:88	Calotropis gigantea fruit bunch	58:88	Calotropis gigantea fruit bunch for ecofriendly polymer composites	58:123	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.
32068059	1	7	from	change	156:161	arg1	properties					166:175	properties	166:175	properties of alkali treatment	166:195	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	1	7	from	change	156:161	arg1	properties					267:276	the physicochemical, structural, thermal and surface morphological properties	200:276	the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers	200:325	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	5	8	theme	elements	925:932	arg1	removal					899:905	the removal	895:905	the removal of non-cellulosic elements and surface impurities	895:955	Scanning electron microscopy and Atomic force microscopy images showed the partially roughened surface of the fiber due to the removal of non-cellulosic elements and surface impurities during alkali treatment.
32068059	4	9	theme	Calotropis	689:698	arg1	fibers					721:726	alkali-treated Calotropis gigantea fruit bunch fibers	674:726	alkali-treated Calotropis gigantea fruit bunch fibers	674:726	Thermal degradability and stability of alkali-treated Calotropis gigantea fruit bunch fibers were more than that of the untreated fiber.
32068059	1	10	theme	morphological	253:265	arg1	properties					267:276	the physicochemical, structural, thermal and surface morphological properties	200:276	the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers	200:325	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	4	11	theme	untreated	755:763	arg1	fiber					765:769	the untreated fiber	751:769	the untreated fiber	751:769	Thermal degradability and stability of alkali-treated Calotropis gigantea fruit bunch fibers were more than that of the untreated fiber.
32068059	2	12	theme	amorphous	395:403	arg1	contents					405:412	the amorphous contents	391:412	the amorphous contents	391:412	The alkali-treatment was discovered to reduce the amorphous contents and removed the non-cellulosic components which were inveterate by the FTIR analysis.
32068059	0	13	theme	polymer	106:112	arg1	composites					114:123	ecofriendly polymer composites	94:123	ecofriendly polymer composites	94:123	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.
32068059	2	14	theme	FTIR	485:488	arg1	analysis					490:497	the FTIR analysis	481:497	the FTIR analysis	481:497	The alkali-treatment was discovered to reduce the amorphous contents and removed the non-cellulosic components which were inveterate by the FTIR analysis.
32068059	3	15	theme	crystallinity	546:558	arg1	index					560:564	the crystallinity index	542:564	the crystallinity index of the alkali-treated CGFB fibers	542:598	The X-ray diffraction pattern showed that the crystallinity index of the alkali-treated CGFB fibers was fairly higher than raw fibers.
32068059	3	15	theme	crystallinity	546:558	arg1	higher					611:616	higher	611:616	higher	611:616	The X-ray diffraction pattern showed that the crystallinity index of the alkali-treated CGFB fibers was fairly higher than raw fibers.
32068059	4	16	theme	alkali-treated	674:687	arg1	fibers					721:726	alkali-treated Calotropis gigantea fruit bunch fibers	674:726	alkali-treated Calotropis gigantea fruit bunch fibers	674:726	Thermal degradability and stability of alkali-treated Calotropis gigantea fruit bunch fibers were more than that of the untreated fiber.
32068059	5	17	theme	Atomic	805:810	arg1	microscopy					818:827	Atomic force microscopy	805:827	Atomic force microscopy	805:827	Scanning electron microscopy and Atomic force microscopy images showed the partially roughened surface of the fiber due to the removal of non-cellulosic elements and surface impurities during alkali treatment.
32068059	5	18	theme	electron	781:788	arg1	microscopy					790:799	Scanning electron microscopy	772:799	Scanning electron microscopy	772:799	Scanning electron microscopy and Atomic force microscopy images showed the partially roughened surface of the fiber due to the removal of non-cellulosic elements and surface impurities during alkali treatment.
32068059	3	19	theme	CGFB	588:591	arg1	fibers					593:598	the alkali-treated CGFB fibers	569:598	the alkali-treated CGFB fibers	569:598	The X-ray diffraction pattern showed that the crystallinity index of the alkali-treated CGFB fibers was fairly higher than raw fibers.
32068059	4	20	theme	fruit	709:713	arg1	fibers					721:726	alkali-treated Calotropis gigantea fruit bunch fibers	674:726	alkali-treated Calotropis gigantea fruit bunch fibers	674:726	Thermal degradability and stability of alkali-treated Calotropis gigantea fruit bunch fibers were more than that of the untreated fiber.
32068059	3	21	theme	fibers	593:598	arg1	index					560:564	the crystallinity index	542:564	the crystallinity index of the alkali-treated CGFB fibers	542:598	The X-ray diffraction pattern showed that the crystallinity index of the alkali-treated CGFB fibers was fairly higher than raw fibers.
32068059	3	21	theme	fibers	593:598	arg1	higher					611:616	higher	611:616	higher	611:616	The X-ray diffraction pattern showed that the crystallinity index of the alkali-treated CGFB fibers was fairly higher than raw fibers.
32068059	1	22	theme	alkali	180:185	arg1	treatment					187:195	alkali treatment	180:195	alkali treatment	180:195	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	0	23	theme	novel	22:26	arg1	fiber					47:51	a novel natural cellulosic fiber	20:51	a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites	20:123	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.
32068059	1	24	theme	Calotropis	281:290	arg1	fibers					320:325	Calotropis gigantea fruit bunch (CGFB) fibers	281:325	Calotropis gigantea fruit bunch (CGFB) fibers	281:325	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	1	25	theme	treatment	187:195	arg1	properties					166:175	properties	166:175	properties of alkali treatment	166:195	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	2	26	theme	non-cellulosic	430:443	arg1	components					445:454	the non-cellulosic components	426:454	the non-cellulosic components which were inveterate by the FTIR analysis	426:497	The alkali-treatment was discovered to reduce the amorphous contents and removed the non-cellulosic components which were inveterate by the FTIR analysis.
32068059	2	26	theme	non-cellulosic	430:443	arg1	inveterate					467:476	inveterate	467:476	inveterate	467:476	The alkali-treatment was discovered to reduce the amorphous contents and removed the non-cellulosic components which were inveterate by the FTIR analysis.
32068059	1	27	theme	gigantea	292:299	arg1	fibers					320:325	Calotropis gigantea fruit bunch (CGFB) fibers	281:325	Calotropis gigantea fruit bunch (CGFB) fibers	281:325	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	0	28	from	bunch	84:88	arg1	Characterization					0:15	Characterization	0:15	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.	0:124	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.
32068059	0	28	from	bunch	84:88	arg1	fiber					47:51	a novel natural cellulosic fiber	20:51	a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites	20:123	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.
32068059	3	29	theme	alkali-treated	573:586	arg1	fibers					593:598	the alkali-treated CGFB fibers	569:598	the alkali-treated CGFB fibers	569:598	The X-ray diffraction pattern showed that the crystallinity index of the alkali-treated CGFB fibers was fairly higher than raw fibers.
32068059	5	30	theme	non-cellulosic	910:923	arg1	elements					925:932	non-cellulosic elements	910:932	non-cellulosic elements	910:932	Scanning electron microscopy and Atomic force microscopy images showed the partially roughened surface of the fiber due to the removal of non-cellulosic elements and surface impurities during alkali treatment.
32068059	0	31	theme	cellulosic	36:45	arg1	fiber					47:51	a novel natural cellulosic fiber	20:51	a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites	20:123	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.
32068059	1	32	theme	fruit	301:305	arg1	fibers					320:325	Calotropis gigantea fruit bunch (CGFB) fibers	281:325	Calotropis gigantea fruit bunch (CGFB) fibers	281:325	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	4	33	theme	gigantea	700:707	arg1	fibers					721:726	alkali-treated Calotropis gigantea fruit bunch fibers	674:726	alkali-treated Calotropis gigantea fruit bunch fibers	674:726	Thermal degradability and stability of alkali-treated Calotropis gigantea fruit bunch fibers were more than that of the untreated fiber.
32068059	5	34	theme	fiber	882:886	arg1	surface					867:873	the partially roughened surface	843:873	the partially roughened surface of the fiber	843:886	Scanning electron microscopy and Atomic force microscopy images showed the partially roughened surface of the fiber due to the removal of non-cellulosic elements and surface impurities during alkali treatment.
32068059	0	35	theme	natural	28:34	arg1	fiber					47:51	a novel natural cellulosic fiber	20:51	a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites	20:123	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.
32068059	1	36	theme	bunch	307:311	arg1	fibers					320:325	Calotropis gigantea fruit bunch (CGFB) fibers	281:325	Calotropis gigantea fruit bunch (CGFB) fibers	281:325	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	5	37	theme	microscopy	818:827	arg1	images					829:834	Scanning electron microscopy and Atomic force microscopy images	772:834	Scanning electron microscopy and Atomic force microscopy images	772:834	Scanning electron microscopy and Atomic force microscopy images showed the partially roughened surface of the fiber due to the removal of non-cellulosic elements and surface impurities during alkali treatment.
32068059	5	38	theme	roughened	857:865	arg1	surface					867:873	the partially roughened surface	843:873	the partially roughened surface of the fiber	843:886	Scanning electron microscopy and Atomic force microscopy images showed the partially roughened surface of the fiber due to the removal of non-cellulosic elements and surface impurities during alkali treatment.
32068059	1	39	theme	physicochemical	204:218	arg1	properties					267:276	the physicochemical, structural, thermal and surface morphological properties	200:276	the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers	200:325	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	5	40	theme	microscopy	790:799	arg1	images					829:834	Scanning electron microscopy and Atomic force microscopy images	772:834	Scanning electron microscopy and Atomic force microscopy images	772:834	Scanning electron microscopy and Atomic force microscopy images showed the partially roughened surface of the fiber due to the removal of non-cellulosic elements and surface impurities during alkali treatment.
32068059	5	41	theme	impurities	946:955	arg1	removal					899:905	the removal	895:905	the removal of non-cellulosic elements and surface impurities	895:955	Scanning electron microscopy and Atomic force microscopy images showed the partially roughened surface of the fiber due to the removal of non-cellulosic elements and surface impurities during alkali treatment.
32068059	0	42	theme	fiber	47:51	arg1	Characterization					0:15	Characterization	0:15	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.	0:124	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.
32068059	1	43	theme	CGFB	314:317	arg1	fibers					320:325	Calotropis gigantea fruit bunch (CGFB) fibers	281:325	Calotropis gigantea fruit bunch (CGFB) fibers	281:325	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	3	44	theme	X-ray	504:508	arg1	pattern					522:528	The X-ray diffraction pattern	500:528	The X-ray diffraction pattern	500:528	The X-ray diffraction pattern showed that the crystallinity index of the alkali-treated CGFB fibers was fairly higher than raw fibers.
32068059	5	45	theme	alkali	964:969	arg1	treatment					971:979	alkali treatment	964:979	alkali treatment	964:979	Scanning electron microscopy and Atomic force microscopy images showed the partially roughened surface of the fiber due to the removal of non-cellulosic elements and surface impurities during alkali treatment.
32068059	1	46	theme	current	134:140	arg1	research					142:149	this current research	129:149	this current research	129:149	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	1	47	theme	structural	221:230	arg1	properties					267:276	the physicochemical, structural, thermal and surface morphological properties	200:276	the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers	200:325	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	0	48	theme	gigantea	69:76	arg1	bunch					84:88	Calotropis gigantea fruit bunch	58:88	Calotropis gigantea fruit bunch for ecofriendly polymer composites	58:123	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.
32068059	3	49	theme	raw	623:625	arg1	fibers					627:632	raw fibers	623:632	raw fibers	623:632	The X-ray diffraction pattern showed that the crystallinity index of the alkali-treated CGFB fibers was fairly higher than raw fibers.
32068059	4	50	theme	fibers	721:726	arg1	stability					661:669	stability	661:669	stability	661:669	Thermal degradability and stability of alkali-treated Calotropis gigantea fruit bunch fibers were more than that of the untreated fiber.
32068059	4	50	theme	fibers	721:726	arg1	degradability					643:655	Thermal degradability	635:655	Thermal degradability	635:655	Thermal degradability and stability of alkali-treated Calotropis gigantea fruit bunch fibers were more than that of the untreated fiber.
32068059	4	51	theme	Thermal	635:641	arg1	degradability					643:655	Thermal degradability	635:655	Thermal degradability	635:655	Thermal degradability and stability of alkali-treated Calotropis gigantea fruit bunch fibers were more than that of the untreated fiber.
32068059	0	52	theme	Calotropis	58:67	arg1	bunch					84:88	Calotropis gigantea fruit bunch	58:88	Calotropis gigantea fruit bunch for ecofriendly polymer composites	58:123	Characterization of a novel natural cellulosic fiber from Calotropis gigantea fruit bunch for ecofriendly polymer composites.
32068059	1	53	theme	fibers	320:325	arg1	properties					267:276	the physicochemical, structural, thermal and surface morphological properties	200:276	the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers	200:325	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
32068059	4	54	theme	bunch	715:719	arg1	fibers					721:726	alkali-treated Calotropis gigantea fruit bunch fibers	674:726	alkali-treated Calotropis gigantea fruit bunch fibers	674:726	Thermal degradability and stability of alkali-treated Calotropis gigantea fruit bunch fibers were more than that of the untreated fiber.
32068059	1	55	theme	thermal	233:239	arg1	properties					267:276	the physicochemical, structural, thermal and surface morphological properties	200:276	the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers	200:325	In this current research, the change in properties of alkali treatment on the physicochemical, structural, thermal and surface morphological properties of Calotropis gigantea fruit bunch (CGFB) fibers are investigated.
33921906	1	0	theme	morphological	342:354	arg1	properties					371:380	the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties	221:380	the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin	221:447	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	1	1	from	degradation	263:273	arg1	fluids					293:298	simulated body fluids	278:298	simulated body fluids	278:298	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	1	2	theme	SA/PVA	385:390	arg1	hydrogels					392:400	SA/PVA hydrogels	385:400	SA/PVA hydrogels containing active substances of natural origin	385:447	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	5	3	contain	contained	878:886	arg2	amounts					1067:1073	different amounts	1057:1073	different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v)	1057:1134	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	3	contain	contained	878:886	arg1	hydrogels					868:876	purpurea-based hydrogels	853:876	purpurea-based hydrogels	853:876	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	3	contain	contained	878:886	arg2	-in					1034:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in	901:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	3	contain	contained	878:886	arg2	extract					1090:1096	the aqueous extract	1078:1096	the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v)	1078:1134	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	3	contain	contained	878:886	arg2	polymer					890:896	a polymer	888:896	a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	888:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	3	4	theme	ethylene	654:661	arg1	poly					649:652	poly	649:652	poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol)	649:704	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	3	4	theme	ethylene	654:661	arg1	glycol					663:668	ethylene glycol	654:668	ethylene glycol	654:668	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	1	5	from	ability	251:257	arg1	fluids					293:298	simulated body fluids	278:298	simulated body fluids	278:298	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	1	6	theme	physicochemical	225:239	arg1	properties					371:380	the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties	221:380	the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin	221:447	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	3	7	from	reaction	759:766	arg1	presence					775:782	the presence	771:782	the presence of a 5% w/v calcium chloride solution	771:820	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	0	8	theme	Alcohol	99:105	arg1	Hydrogels					108:116	Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels	63:116	Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels	63:116	Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels.
33921906	5	9	theme	-and	951:954	arg1	-in					1034:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in	901:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	2	10	theme	Echinacea	479:487	arg1	purpurea					489:496	Echinacea purpurea	479:496	Echinacea purpurea	479:496	First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus.
33921906	0	11	theme	Hydrogels	108:116	arg1	Properties					49:58	the Properties	45:58	the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels	45:116	Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels.
33921906	5	12	theme	synthetic	958:966	arg1	alcohol					987:993	vinyl alcohol	981:993	vinyl alcohol	981:993	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	12	theme	synthetic	958:966	arg1	polymer-poly					968:979	a synthetic polymer-poly	956:979	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	1	13	theme	crosslinking	176:187	arg1	methods					189:195	different crosslinking methods	166:195	different crosslinking methods (ionic and chemical)	166:216	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	2	14	theme	Soxhlet	519:525	arg1	apparatus					527:535	a Soxhlet apparatus	517:535	a Soxhlet apparatus	517:535	First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus.
33921906	3	15	theme	=	693:693	arg1	g/mol					699:703	PEGDA, Mn = 700 g/mol	683:703	g/mol	699:703	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	3	15	theme	=	693:693	arg1	diacrylate					671:680	poly(ethylene glycol) diacrylate	649:680	poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol)	649:704	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	1	16	theme	SEM	357:359	arg1	analysis					361:368	SEM analysis	357:368	SEM analysis	357:368	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	1	17	from	influence	153:161	arg1	properties					371:380	the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties	221:380	the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin	221:447	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	7	18	theme	release	1362:1368	arg1	profile					1370:1376	the release profile	1358:1376	the release profile	1358:1376	The results indicate that the type of the crosslinking method has a direct impact on the release profile.
33921906	3	19	theme	crosslinking	711:722	arg1	agent					724:728	a crosslinking agent	709:728	a crosslinking agent	709:728	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	3	19	theme	crosslinking	711:722	arg1	diacrylate					671:680	poly(ethylene glycol) diacrylate	649:680	poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol)	649:704	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	3	20	theme	modified	556:563	arg1	hydrogels					578:586	modified SA/PVA-based hydrogels	556:586	modified SA/PVA-based hydrogels	556:586	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	1	21	theme	body	288:291	arg1	fluids					293:298	simulated body fluids	278:298	simulated body fluids	278:298	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	7	22	theme	direct	1341:1346	arg1	impact					1348:1353	a direct impact	1339:1353	a direct impact on the release profile	1339:1376	The results indicate that the type of the crosslinking method has a direct impact on the release profile.
33921906	0	23	from	Impact	0:5	arg1	Properties					49:58	the Properties	45:58	the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels	45:116	Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels.
33921906	5	24	theme	extract	1090:1096	arg1	polymer					890:896	a polymer	888:896	a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	888:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	24	theme	extract	1090:1096	arg1	extract					1090:1096	the aqueous extract	1078:1096	the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v)	1078:1134	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	24	theme	extract	1090:1096	arg1	-in					1034:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in	901:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	24	theme	extract	1090:1096	arg1	amounts					1067:1073	different amounts	1057:1073	different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v)	1057:1134	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	0	25	theme	Sodium	72:77	arg1	Hydrogels					108:116	Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels	63:116	Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels	63:116	Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels.
33921906	1	26	theme	structural	302:311	arg1	properties					371:380	the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties	221:380	the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin	221:447	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	3	27	theme	w/v	792:794	arg1	solution					813:820	a 5% w/v calcium chloride solution	787:820	a 5% w/v calcium chloride solution	787:820	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	7	28	theme	crosslinking	1315:1326	arg1	method					1328:1333	the crosslinking method	1311:1333	the crosslinking method	1311:1333	The results indicate that the type of the crosslinking method has a direct impact on the release profile.
33921906	5	29	theme	%	1128:1128	arg1	extract					1090:1096	the aqueous extract	1078:1096	the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v)	1078:1134	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	1	30	theme	FT-IR	314:318	arg1	analysis					328:335	FT-IR spectra analysis	314:335	FT-IR spectra analysis	314:335	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	6	31	theme	polymeric	1197:1205	arg1	matrix					1207:1212	the polymeric matrix	1193:1212	the polymeric matrix	1193:1212	Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C.
33921906	3	32	theme	5	789:789	arg1	%					790:790	%	790:790	%	790:790	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	5	33	theme	10	1021:1022	arg1	%					1023:1023	%	1023:1023	%	1023:1023	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	1	34	theme	swelling	242:249	arg1	ability					251:257	swelling ability	242:257	swelling ability	242:257	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	3	35	theme	chloride	804:811	arg1	solution					813:820	a 5% w/v calcium chloride solution	787:820	a 5% w/v calcium chloride solution	787:820	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	5	36	theme	=	1005:1005	arg1	PVA					997:999	PVA	997:999	PVA	997:999	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	36	theme	=	1005:1005	arg1	Mn					1002:1003	Mn	1002:1003	Mn = 72,000 g/mol	1002:1018	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	3	37	theme	hydrogels	578:586	arg1	series					546:551	a series	544:551	a series of modified SA/PVA-based hydrogels	544:586	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	1	38	theme	origin	442:447	arg1	substances					420:429	active substances	413:429	active substances of natural origin	413:447	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	0	39	theme	Agents	35:40	arg1	Type					14:17	the Type	10:17	the Type of Crosslinking Agents	10:40	Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels.
33921906	3	40	theme	crosslinking	623:634	arg1	method					636:641	the chemical crosslinking method	610:641	the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution	610:820	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	1	41	theme	methods	189:195	arg1	influence					153:161	the influence	149:161	the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin	149:447	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	5	42	dep	polymer-poly	968:979	arg1	PVA					997:999	PVA	997:999	PVA	997:999	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	42	dep	polymer-poly	968:979	arg1	solution					1025:1032	10% solution	1021:1032	10% solution	1021:1032	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	42	dep	polymer-poly	968:979	arg1	Mn					1002:1003	Mn	1002:1003	Mn = 72,000 g/mol	1002:1018	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	43	theme	different	1057:1065	arg1	-in					1034:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in	901:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	43	theme	different	1057:1065	arg1	extract					1090:1096	the aqueous extract	1078:1096	the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v)	1078:1134	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	43	theme	different	1057:1065	arg1	amounts					1067:1073	different amounts	1057:1073	different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v)	1057:1134	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	44	theme	origin-sodium	909:921	arg1	solution					942:949	SA, 1.5% solution	933:949	solution	942:949	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	44	theme	origin-sodium	909:921	arg1	alginate					923:930	natural origin-sodium alginate	901:930	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	6	45	theme	release	1155:1161	arg1	behavior					1163:1170	the release behavior	1151:1170	the release behavior of echinacoside from the polymeric matrix	1151:1212	Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C.
33921906	5	46	theme	-in	1034:1036	arg1	polymer					890:896	a polymer	888:896	a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	888:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	46	theme	-in	1034:1036	arg1	extract					1090:1096	the aqueous extract	1078:1096	the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v)	1078:1134	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	46	theme	-in	1034:1036	arg1	-in					1034:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in	901:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	46	theme	-in	1034:1036	arg1	amounts					1067:1073	different amounts	1057:1073	different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v)	1057:1134	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	7	47	contain	has	1335:1337	arg2	impact					1348:1353	a direct impact	1339:1353	a direct impact on the release profile	1339:1376	The results indicate that the type of the crosslinking method has a direct impact on the release profile.
33921906	7	47	contain	has	1335:1337	arg1	type					1303:1306	the type	1299:1306	the type of the crosslinking method	1299:1333	The results indicate that the type of the crosslinking method has a direct impact on the release profile.
33921906	6	48	theme	phosphate-buffered	1231:1248	arg1	PBS					1258:1260	PBS	1258:1260	PBS	1258:1260	Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C.
33921906	6	48	theme	phosphate-buffered	1231:1248	arg1	saline					1250:1255	phosphate-buffered saline	1231:1255	phosphate-buffered saline (PBS)	1231:1261	Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C.
33921906	5	49	theme	ratio	1042:1046	arg1	2:1					1048:1050	the ratio 2:1	1038:1050	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	1	50	theme	hydrogels	392:400	arg1	properties					371:380	the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties	221:380	the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin	221:447	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	8	51	theme	active	1444:1449	arg1	substance					1451:1459	an active substance	1441:1459	an active substance	1441:1459	Consequently, it is possible to design a system that delivers an active substance in a way that depends on the application.
33921906	6	52	theme	echinacoside	1175:1186	arg1	behavior					1163:1170	the release behavior	1151:1170	the release behavior of echinacoside from the polymeric matrix	1151:1212	Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C.
33921906	1	53	theme	active	413:418	arg1	substances					420:429	active substances	413:429	active substances of natural origin	413:447	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	3	54	theme	Mn	690:691	arg1	g/mol					699:703	PEGDA, Mn = 700 g/mol	683:703	g/mol	699:703	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	3	54	theme	Mn	690:691	arg1	diacrylate					671:680	poly(ethylene glycol) diacrylate	649:680	poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol)	649:704	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	2	55	theme	purpurea	489:496	arg1	extract					468:474	an aqueous extract	457:474	an aqueous extract of Echinacea purpurea	457:496	First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus.
33921906	3	56	theme	PEGDA	683:687	arg1	g/mol					699:703	PEGDA, Mn = 700 g/mol	683:703	g/mol	699:703	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	3	56	theme	PEGDA	683:687	arg1	diacrylate					671:680	poly(ethylene glycol) diacrylate	649:680	poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol)	649:704	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	6	57	from	matrix	1207:1212	arg1	behavior					1163:1170	the release behavior	1151:1170	the release behavior of echinacoside from the polymeric matrix	1151:1212	Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C.
33921906	1	58	theme	different	166:174	arg1	methods					189:195	different crosslinking methods	166:195	different crosslinking methods (ionic and chemical)	166:216	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	1	59	dep	methods	189:195	arg1	ionic					198:202	ionic	198:202	ionic	198:202	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	1	59	dep	methods	189:195	arg1	chemical					208:215	chemical	208:215	chemical	208:215	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	5	60	theme	polymer-poly	968:979	arg1	-in					1034:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in	901:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	61	theme	%	940:940	arg1	solution					942:949	SA, 1.5% solution	933:949	solution	942:949	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	61	theme	%	940:940	arg1	alginate					923:930	natural origin-sodium alginate	901:930	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	62	dep	-in	1034:1036	arg1	2:1					1048:1050	the ratio 2:1	1038:1050	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	3	63	theme	ionic	753:757	arg1	reaction					759:766	the ionic reaction	749:766	the ionic reaction in the presence of a 5% w/v calcium chloride solution	749:820	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	3	63	theme	ionic	753:757	arg1	diacrylate					671:680	poly(ethylene glycol) diacrylate	649:680	poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol)	649:704	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	0	64	theme	Modified	63:70	arg1	Hydrogels					108:116	Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels	63:116	Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels	63:116	Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels.
33921906	1	65	from	studies	138:144	arg1	influence					153:161	the influence	149:161	the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin	149:447	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	7	66	theme	method	1328:1333	arg1	type					1303:1306	the type	1299:1306	the type of the crosslinking method	1299:1333	The results indicate that the type of the crosslinking method has a direct impact on the release profile.
33921906	1	67	dep	physicochemical	225:239	arg1	degradation					263:273	degradation	263:273	degradation	263:273	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	1	67	dep	physicochemical	225:239	arg1	ability					251:257	swelling ability	242:257	swelling ability	242:257	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	5	68	theme	aqueous	1082:1088	arg1	extract					1090:1096	the aqueous extract	1078:1096	the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v)	1078:1134	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	0	69	theme	Alginate/Poly	79:91	arg1	Hydrogels					108:116	Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels	63:116	Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels	63:116	Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels.
33921906	5	70	theme	purpurea-based	853:866	arg1	hydrogels					868:876	purpurea-based hydrogels	853:876	purpurea-based hydrogels	853:876	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	2	71	theme	aqueous	460:466	arg1	extract					468:474	an aqueous extract	457:474	an aqueous extract of Echinacea purpurea	457:496	First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus.
33921906	0	72	theme	vinyl	93:97	arg1	Hydrogels					108:116	Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels	63:116	Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels	63:116	Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels.
33921906	5	73	theme	vinyl	981:985	arg1	alcohol					987:993	vinyl alcohol	981:993	vinyl alcohol	981:993	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	73	theme	vinyl	981:985	arg1	polymer-poly					968:979	a synthetic polymer-poly	956:979	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	3	74	theme	calcium	796:802	arg1	solution					813:820	a 5% w/v calcium chloride solution	787:820	a 5% w/v calcium chloride solution	787:820	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	4	75	theme	SA/PVA/E	843:850	arg1	compositions					827:838	The compositions	823:838	The compositions of SA/PVA/E.	823:851	The compositions of SA/PVA/E.
33921906	5	76	dep	=	1005:1005	arg1	g/mol					1014:1018	72,000 g/mol	1007:1018	72,000 g/mol	1007:1018	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	1	77	dep	morphological	342:354	arg1	analysis					361:368	SEM analysis	357:368	SEM analysis	357:368	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	1	78	theme	spectra	320:326	arg1	analysis					328:335	FT-IR spectra analysis	314:335	FT-IR spectra analysis	314:335	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	3	79	theme	%	790:790	arg1	solution					813:820	a 5% w/v calcium chloride solution	787:820	a 5% w/v calcium chloride solution	787:820	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	0	80	theme	Type	14:17	arg1	Impact					0:5	Impact	0:5	Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels.	0:117	Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels.
33921906	5	81	theme	%	1023:1023	arg1	PVA					997:999	PVA	997:999	PVA	997:999	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	81	theme	%	1023:1023	arg1	solution					1025:1032	10% solution	1021:1032	10% solution	1021:1032	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	0	82	theme	Crosslinking	22:33	arg1	Agents					35:40	Crosslinking Agents	22:40	Crosslinking Agents	22:40	Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels.
33921906	5	83	theme	alginate	923:930	arg1	-in					1034:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in	901:1036	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	3	84	theme	solution	813:820	arg1	presence					775:782	the presence	771:782	the presence of a 5% w/v calcium chloride solution	771:820	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	3	85	theme	SA/PVA-based	565:576	arg1	hydrogels					578:586	modified SA/PVA-based hydrogels	556:586	modified SA/PVA-based hydrogels	556:586	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	1	86	theme	natural	434:440	arg1	origin					442:447	natural origin	434:447	natural origin	434:447	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	5	87	theme	SA	933:934	arg1	solution					942:949	SA, 1.5% solution	933:949	solution	942:949	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	87	theme	SA	933:934	arg1	alginate					923:930	natural origin-sodium alginate	901:930	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	1	88	contain	containing	402:411	arg1	hydrogels					392:400	SA/PVA hydrogels	385:400	SA/PVA hydrogels containing active substances of natural origin	385:447	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	1	88	contain	containing	402:411	arg2	substances					420:429	active substances	413:429	active substances of natural origin	413:447	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	1	89	dep	structural	302:311	arg1	analysis					328:335	FT-IR spectra analysis	314:335	FT-IR spectra analysis	314:335	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	3	90	theme	chemical	614:621	arg1	method					636:641	the chemical crosslinking method	610:641	the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution	610:820	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	1	91	theme	simulated	278:286	arg1	fluids					293:298	simulated body fluids	278:298	simulated body fluids	278:298	Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin.
33921906	7	92	from	impact	1348:1353	arg1	profile					1370:1376	the release profile	1358:1376	the release profile	1358:1376	The results indicate that the type of the crosslinking method has a direct impact on the release profile.
33921906	5	93	dep	%	1128:1128	arg1	E.					1101:1102	E. purpurea-5, 10, 15 or 20% (v/v)	1101:1134	E. purpurea-5, 10, 15 or 20% (v/v)	1101:1134	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	3	94	from	agent	724:728	arg1	presence					775:782	the presence	771:782	the presence of a 5% w/v calcium chloride solution	771:820	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	5	95	theme	natural	901:907	arg1	solution					942:949	SA, 1.5% solution	933:949	solution	942:949	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	5	95	theme	natural	901:907	arg1	alginate					923:930	natural origin-sodium alginate	901:930	natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1	901:1050	purpurea-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea-5, 10, 15 or 20% (v/v).
33921906	3	96	theme	poly	649:652	arg1	reaction					759:766	the ionic reaction	749:766	the ionic reaction in the presence of a 5% w/v calcium chloride solution	749:820	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	3	96	theme	poly	649:652	arg1	agent					724:728	a crosslinking agent	709:728	a crosslinking agent	709:728	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	3	96	theme	poly	649:652	arg1	g/mol					699:703	PEGDA, Mn = 700 g/mol	683:703	g/mol	699:703	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
33921906	3	96	theme	poly	649:652	arg1	diacrylate					671:680	poly(ethylene glycol) diacrylate	649:680	poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol)	649:704	Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution.
34119140	6	0	theme	Young	667:671	arg1	4.3 GPa					709:715	4.3 GPa	709:715	4.3 GPa	709:715	Tensile test results showed that the maximum Young's modulus and tensile strength were 4.3 GPa and 153.8 MPa, respectively.
34119140	6	0	theme	Young	667:671	arg1	modulus					675:681	the maximum Young's modulus	655:681	the maximum Young's modulus	655:681	Tensile test results showed that the maximum Young's modulus and tensile strength were 4.3 GPa and 153.8 MPa, respectively.
34119140	8	1	theme	fabrication	1154:1164	arg1	strategy					1166:1173	the bioinspired fabrication strategy	1138:1173	the bioinspired fabrication strategy	1138:1173	This work validates the effectiveness of the bioinspired fabrication strategy, which inspires further manufacturing and optimization of materials for diverse applications.
34119140	5	2	theme	Detailed	513:520	arg1	characterization					533:548	Detailed structural characterization	513:548	Detailed structural characterization	513:548	Detailed structural characterization revealed the bone-like structure of the HAP-reinforced alginate fibers.
34119140	6	3	theme	maximum	659:665	arg1	4.3 GPa					709:715	4.3 GPa	709:715	4.3 GPa	709:715	Tensile test results showed that the maximum Young's modulus and tensile strength were 4.3 GPa and 153.8 MPa, respectively.
34119140	6	3	theme	maximum	659:665	arg1	modulus					675:681	the maximum Young's modulus	655:681	the maximum Young's modulus	655:681	Tensile test results showed that the maximum Young's modulus and tensile strength were 4.3 GPa and 153.8 MPa, respectively.
34119140	7	4	theme	reinforcing	759:769	arg1	mechanism					771:779	A multiscale reinforcing mechanism	746:779	A multiscale reinforcing mechanism	746:779	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	7	5	with	gels	981:984	arg1	behaviors					1012:1020	different mechanical behaviors	991:1020	different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel)	991:1094	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	5	6	theme	structural	522:531	arg1	characterization					533:548	Detailed structural characterization	513:548	Detailed structural characterization	513:548	Detailed structural characterization revealed the bone-like structure of the HAP-reinforced alginate fibers.
34119140	7	7	theme	compacted	873:881	arg1	nanofibrils					883:893	highly ordered and compacted nanofibrils	854:893	highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale	854:952	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	8	8	theme	further	1191:1197	arg1	manufacturing					1199:1211	further manufacturing	1191:1211	further manufacturing	1191:1211	This work validates the effectiveness of the bioinspired fabrication strategy, which inspires further manufacturing and optimization of materials for diverse applications.
34119140	1	9	theme	Biological	89:98	arg1	materials					100:108	Biological materials	89:108	Biological materials	89:108	Biological materials have excellent mechanical properties due to their organized structures from nano- to macro-scale.
34119140	5	10	theme	fibers	614:619	arg1	structure					573:581	the bone-like structure	559:581	the bone-like structure of the HAP-reinforced alginate fibers	559:619	Detailed structural characterization revealed the bone-like structure of the HAP-reinforced alginate fibers.
34119140	7	11	theme	ordered	861:867	arg1	nanofibrils					883:893	highly ordered and compacted nanofibrils	854:893	highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale	854:952	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	7	12	theme	mechanical	1001:1010	arg1	behaviors					1012:1020	different mechanical behaviors	991:1020	different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel)	991:1094	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	7	13	from	microscale	943:952	arg1	direction					926:934	the longitudinal direction	909:934	the longitudinal direction at the microscale	909:952	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	4	14	theme	alginate	497:504	arg1	fiber					506:510	the alginate fiber	493:510	the alginate fiber	493:510	Organic-inorganic composite fibers were obtained by incorporating aligned hydroxyapatite (HAP) nanowires into the alginate fiber.
34119140	7	15	from	nanoscale	1029:1037	arg1	behaviors					1012:1020	different mechanical behaviors	991:1020	different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel)	991:1094	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	3	16	theme	stress-induced	319:332	arg1	method					334:339	a stress-induced method	317:339	a stress-induced method to fabricate anisotropic alginate fibers	317:380	We described a stress-induced method to fabricate anisotropic alginate fibers.
34119140	4	17	theme	HAP	473:475	arg1	nanowires					478:486	aligned hydroxyapatite (HAP) nanowires	449:486	aligned hydroxyapatite (HAP) nanowires	449:486	Organic-inorganic composite fibers were obtained by incorporating aligned hydroxyapatite (HAP) nanowires into the alginate fiber.
34119140	4	18	theme	Organic-inorganic	383:399	arg1	fibers					411:416	Organic-inorganic composite fibers	383:416	Organic-inorganic composite fibers	383:416	Organic-inorganic composite fibers were obtained by incorporating aligned hydroxyapatite (HAP) nanowires into the alginate fiber.
34119140	0	19	theme	alginate	26:33	arg1	fibers					35:40	Hydroxyapatite-reinforced alginate fibers	0:40	Hydroxyapatite-reinforced alginate fibers with bioinspired dually aligned architectures	0:86	Hydroxyapatite-reinforced alginate fibers with bioinspired dually aligned architectures.
34119140	8	20	theme	materials	1233:1241	arg1	optimization					1217:1228	optimization	1217:1228	optimization of materials for diverse applications	1217:1266	This work validates the effectiveness of the bioinspired fabrication strategy, which inspires further manufacturing and optimization of materials for diverse applications.
34119140	8	20	theme	materials	1233:1241	arg1	manufacturing					1199:1211	further manufacturing	1191:1211	further manufacturing	1191:1211	This work validates the effectiveness of the bioinspired fabrication strategy, which inspires further manufacturing and optimization of materials for diverse applications.
34119140	8	21	theme	bioinspired	1142:1152	arg1	strategy					1166:1173	the bioinspired fabrication strategy	1138:1173	the bioinspired fabrication strategy	1138:1173	This work validates the effectiveness of the bioinspired fabrication strategy, which inspires further manufacturing and optimization of materials for diverse applications.
34119140	1	22	theme	excellent	115:123	arg1	properties					136:145	excellent mechanical properties	115:145	excellent mechanical properties	115:145	Biological materials have excellent mechanical properties due to their organized structures from nano- to macro-scale.
34119140	7	23	theme	different	991:999	arg1	behaviors					1012:1020	different mechanical behaviors	991:1020	different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel)	991:1094	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	0	24	theme	Hydroxyapatite-reinforced	0:24	arg1	fibers					35:40	Hydroxyapatite-reinforced alginate fibers	0:40	Hydroxyapatite-reinforced alginate fibers with bioinspired dually aligned architectures	0:86	Hydroxyapatite-reinforced alginate fibers with bioinspired dually aligned architectures.
34119140	1	25	contain	have	110:113	arg1	materials					100:108	Biological materials	89:108	Biological materials	89:108	Biological materials have excellent mechanical properties due to their organized structures from nano- to macro-scale.
34119140	1	25	contain	have	110:113	arg2	properties					136:145	excellent mechanical properties	115:145	excellent mechanical properties	115:145	Biological materials have excellent mechanical properties due to their organized structures from nano- to macro-scale.
34119140	1	26	theme	mechanical	125:134	arg1	properties					136:145	excellent mechanical properties	115:145	excellent mechanical properties	115:145	Biological materials have excellent mechanical properties due to their organized structures from nano- to macro-scale.
34119140	7	27	theme	alginate	972:979	arg1	gels					981:984	alginate gels	972:984	alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel)	972:1094	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	7	28	theme	multiscale	748:757	arg1	mechanism					771:779	A multiscale reinforcing mechanism	746:779	A multiscale reinforcing mechanism	746:779	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	6	29	theme	test	630:633	arg1	results					635:641	Tensile test results	622:641	Tensile test results	622:641	Tensile test results showed that the maximum Young's modulus and tensile strength were 4.3 GPa and 153.8 MPa, respectively.
34119140	1	30	from	nano-	186:190	arg1	structures					170:179	their organized structures	154:179	their organized structures from nano- to macro-scale	154:205	Biological materials have excellent mechanical properties due to their organized structures from nano- to macro-scale.
34119140	7	31	theme	gels	981:984	arg1	kinds					963:967	two kinds	959:967	two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel)	959:1094	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	7	31	theme	gels	981:984	arg1	nanofibrils					883:893	highly ordered and compacted nanofibrils	854:893	highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale	854:952	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	3	32	theme	anisotropic	354:364	arg1	fibers					375:380	anisotropic alginate fibers	354:380	anisotropic alginate fibers	354:380	We described a stress-induced method to fabricate anisotropic alginate fibers.
34119140	7	33	theme	relationship	840:851	arg1	discussion					803:812	the discussion	799:812	the discussion of the structure-property relationship	799:851	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	5	34	theme	HAP-reinforced	590:603	arg1	fibers					614:619	the HAP-reinforced alginate fibers	586:619	the HAP-reinforced alginate fibers	586:619	Detailed structural characterization revealed the bone-like structure of the HAP-reinforced alginate fibers.
34119140	5	35	theme	alginate	605:612	arg1	fibers					614:619	the HAP-reinforced alginate fibers	586:619	the HAP-reinforced alginate fibers	586:619	Detailed structural characterization revealed the bone-like structure of the HAP-reinforced alginate fibers.
34119140	0	36	theme	bioinspired	47:57	arg1	architectures					74:86	bioinspired dually aligned architectures	47:86	bioinspired dually aligned architectures	47:86	Hydroxyapatite-reinforced alginate fibers with bioinspired dually aligned architectures.
34119140	2	37	theme	Artificial	208:217	arg1	manufacture					219:229	Artificial manufacture	208:229	Artificial manufacture of materials with anisotropic microstructures	208:275	Artificial manufacture of materials with anisotropic microstructures still remains challenging.
34119140	8	38	theme	strategy	1166:1173	arg1	effectiveness					1121:1133	the effectiveness	1117:1133	the effectiveness	1117:1133	This work validates the effectiveness of the bioinspired fabrication strategy, which inspires further manufacturing and optimization of materials for diverse applications.
34119140	6	39	theme	Tensile	622:628	arg1	results					635:641	Tensile test results	622:641	Tensile test results	622:641	Tensile test results showed that the maximum Young's modulus and tensile strength were 4.3 GPa and 153.8 MPa, respectively.
34119140	6	40	theme	tensile	687:693	arg1	strength					695:702	tensile strength	687:702	tensile strength	687:702	Tensile test results showed that the maximum Young's modulus and tensile strength were 4.3 GPa and 153.8 MPa, respectively.
34119140	7	41	theme	structure-property	821:838	arg1	relationship					840:851	the structure-property relationship	817:851	the structure-property relationship	817:851	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	0	42	with	fibers	35:40	arg1	architectures					74:86	bioinspired dually aligned architectures	47:86	bioinspired dually aligned architectures	47:86	Hydroxyapatite-reinforced alginate fibers with bioinspired dually aligned architectures.
34119140	0	43	theme	aligned	66:72	arg1	architectures					74:86	bioinspired dually aligned architectures	47:86	bioinspired dually aligned architectures	47:86	Hydroxyapatite-reinforced alginate fibers with bioinspired dually aligned architectures.
34119140	7	44	theme	longitudinal	913:924	arg1	direction					926:934	the longitudinal direction	909:934	the longitudinal direction at the microscale	909:952	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	8	45	theme	diverse	1247:1253	arg1	applications					1255:1266	diverse applications	1247:1266	diverse applications	1247:1266	This work validates the effectiveness of the bioinspired fabrication strategy, which inspires further manufacturing and optimization of materials for diverse applications.
34119140	4	46	theme	hydroxyapatite	457:470	arg1	nanowires					478:486	aligned hydroxyapatite (HAP) nanowires	449:486	aligned hydroxyapatite (HAP) nanowires	449:486	Organic-inorganic composite fibers were obtained by incorporating aligned hydroxyapatite (HAP) nanowires into the alginate fiber.
34119140	7	47	theme	alginate	1057:1064	arg1	gel					1066:1068	acidic alginate gel and calcium-alginate gel	1050:1093	gel	1066:1068	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	7	48	theme	calcium-alginate	1074:1089	arg1	gel					1091:1093	acidic alginate gel and calcium-alginate gel	1050:1093	gel	1091:1093	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34119140	3	49	theme	alginate	366:373	arg1	fibers					375:380	anisotropic alginate fibers	354:380	anisotropic alginate fibers	354:380	We described a stress-induced method to fabricate anisotropic alginate fibers.
34119140	2	50	theme	anisotropic	249:259	arg1	microstructures					261:275	anisotropic microstructures	249:275	anisotropic microstructures	249:275	Artificial manufacture of materials with anisotropic microstructures still remains challenging.
34119140	4	51	theme	aligned	449:455	arg1	nanowires					478:486	aligned hydroxyapatite (HAP) nanowires	449:486	aligned hydroxyapatite (HAP) nanowires	449:486	Organic-inorganic composite fibers were obtained by incorporating aligned hydroxyapatite (HAP) nanowires into the alginate fiber.
34119140	1	52	theme	organized	160:168	arg1	structures					170:179	their organized structures	154:179	their organized structures from nano- to macro-scale	154:205	Biological materials have excellent mechanical properties due to their organized structures from nano- to macro-scale.
34119140	2	53	with	manufacture	219:229	arg1	microstructures					261:275	anisotropic microstructures	249:275	anisotropic microstructures	249:275	Artificial manufacture of materials with anisotropic microstructures still remains challenging.
34119140	5	54	theme	bone-like	563:571	arg1	structure					573:581	the bone-like structure	559:581	the bone-like structure of the HAP-reinforced alginate fibers	559:619	Detailed structural characterization revealed the bone-like structure of the HAP-reinforced alginate fibers.
34119140	2	55	theme	materials	234:242	arg1	manufacture					219:229	Artificial manufacture	208:229	Artificial manufacture of materials with anisotropic microstructures	208:275	Artificial manufacture of materials with anisotropic microstructures still remains challenging.
34119140	4	56	theme	composite	401:409	arg1	fibers					411:416	Organic-inorganic composite fibers	383:416	Organic-inorganic composite fibers	383:416	Organic-inorganic composite fibers were obtained by incorporating aligned hydroxyapatite (HAP) nanowires into the alginate fiber.
34119140	7	57	theme	acidic	1050:1055	arg1	gel					1066:1068	acidic alginate gel and calcium-alginate gel	1050:1093	gel	1066:1068	A multiscale reinforcing mechanism is proposed after the discussion of the structure-property relationship: highly ordered and compacted nanofibrils aligned along the longitudinal direction at the microscale, and two kinds of alginate gels with different mechanical behaviors at the nanoscale coexisted (acidic alginate gel and calcium-alginate gel).
34450146	11	0	theme	drug	1474:1477	arg1	packaging					1443:1451	food packaging	1438:1451	food packaging	1438:1451	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	11	0	theme	drug	1474:1477	arg1	delivery					1479:1486	drug delivery	1474:1486	drug delivery	1474:1486	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	9	1	theme	SSd-BC/Ch	1243:1251	arg1	hydrogels					1253:1261	SSd-BC/Ch hydrogels	1243:1261	SSd-BC/Ch hydrogels	1243:1261	We use FESEM to observe bacterial morphology before and after exposure to SSd-BC/Ch hydrogels.
34450146	0	2	theme	silver	106:111	arg1	sulfadiazine					113:124	silver sulfadiazine	106:124	silver sulfadiazine	106:124	Preparation and characterization of antibacterial bacterial cellulose/chitosan hydrogels impregnated with silver sulfadiazine.
34450146	11	3	theme	antibacterial	1378:1390	arg1	hydrogels					1392:1400	These antibacterial hydrogels	1372:1400	These antibacterial hydrogels	1372:1400	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	6	4	theme	hydrogels	864:872	arg1	morphology					819:828	morphology	819:828	morphology	819:828	The elemental composition, morphology, and mechanical properties of the hydrogels were characterized.
34450146	6	4	theme	hydrogels	864:872	arg1	composition					806:816	The elemental composition	792:816	The elemental composition	792:816	The elemental composition, morphology, and mechanical properties of the hydrogels were characterized.
34450146	6	4	theme	hydrogels	864:872	arg1	properties					846:855	mechanical properties	835:855	mechanical properties	835:855	The elemental composition, morphology, and mechanical properties of the hydrogels were characterized.
34450146	7	5	theme	cellulose-chitosan	930:947	arg1	hydrogels					949:957	bacterial cellulose-chitosan hydrogels	920:957	bacterial cellulose-chitosan hydrogels	920:957	Incorporation of SSd into bacterial cellulose-chitosan hydrogels significantly improved their mechanical and antibacterial properties.
34450146	10	6	theme	permeability	1296:1307	arg1	kit					1309:1311	The BacLight LIVE/DEAD membrane permeability kit	1264:1311	The BacLight LIVE/DEAD membrane permeability kit	1264:1311	The BacLight LIVE/DEAD membrane permeability kit is used to evaluate the membrane permeability of bacteria.
34450146	10	7	theme	membrane	1287:1294	arg1	kit					1309:1311	The BacLight LIVE/DEAD membrane permeability kit	1264:1311	The BacLight LIVE/DEAD membrane permeability kit	1264:1311	The BacLight LIVE/DEAD membrane permeability kit is used to evaluate the membrane permeability of bacteria.
34450146	1	8	contain	have	208:211	arg1	Hydrogels					127:135	Hydrogels	127:135	Hydrogels with pH sensitivity and stable mechanical and antibacterial properties	127:206	Hydrogels with pH sensitivity and stable mechanical and antibacterial properties have many desirable qualities and broad applications.
34450146	1	8	contain	have	208:211	arg2	applications					248:259	broad applications	242:259	broad applications	242:259	Hydrogels with pH sensitivity and stable mechanical and antibacterial properties have many desirable qualities and broad applications.
34450146	1	8	contain	have	208:211	arg2	qualities					228:236	many desirable qualities	213:236	many desirable qualities	213:236	Hydrogels with pH sensitivity and stable mechanical and antibacterial properties have many desirable qualities and broad applications.
34450146	5	9	theme	amorphous	708:716	arg1	presence					696:703	the presence	692:703	the presence of amorphous and crystalline regions in the hydrogel matrix	692:763	X-ray diffraction confirmed the presence of amorphous and crystalline regions in the hydrogel matrix following addition of SSd.
34450146	2	10	theme	silver	333:338	arg1	sulfadiazine					340:351	silver sulfadiazine	333:351	silver sulfadiazine (<1% w/w)	333:361	A hydrogel based on bacterial cellulose and chitosan, impregnated with silver sulfadiazine (<1% w/w), was prepared using glutaraldehyde as the crosslinking agent.
34450146	2	10	theme	silver	333:338	arg1	%					356:356	<1% w/w	354:360	<1% w/w	354:360	A hydrogel based on bacterial cellulose and chitosan, impregnated with silver sulfadiazine (<1% w/w), was prepared using glutaraldehyde as the crosslinking agent.
34450146	11	11	theme	tissue	1454:1459	arg1	packaging					1443:1451	food packaging	1438:1451	food packaging	1438:1451	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	11	11	theme	tissue	1454:1459	arg1	engineering					1461:1471	tissue engineering	1454:1471	tissue engineering	1454:1471	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	4	12	theme	disk	624:627	arg1	diffusion					629:637	disk diffusion	624:637	disk diffusion	624:637	Micropore size, swelling ratio, pH- sensitivity, and gram positive and negative antibacterial properties were studied by disk diffusion and colony forming unit.
34450146	5	13	theme	SSd	787:789	arg1	addition					775:782	addition	775:782	addition of SSd	775:789	X-ray diffraction confirmed the presence of amorphous and crystalline regions in the hydrogel matrix following addition of SSd.
34450146	11	14	theme	many	1407:1410	arg1	applications					1422:1433	many promising applications	1407:1433	many promising applications	1407:1433	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	11	15	contain	have	1402:1405	arg2	applications					1422:1433	many promising applications	1407:1433	many promising applications	1407:1433	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	11	15	contain	have	1402:1405	arg1	hydrogels					1392:1400	These antibacterial hydrogels	1372:1400	These antibacterial hydrogels	1372:1400	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	7	16	theme	bacterial	920:928	arg1	hydrogels					949:957	bacterial cellulose-chitosan hydrogels	920:957	bacterial cellulose-chitosan hydrogels	920:957	Incorporation of SSd into bacterial cellulose-chitosan hydrogels significantly improved their mechanical and antibacterial properties.
34450146	1	17	theme	many	213:216	arg1	qualities					228:236	many desirable qualities	213:236	many desirable qualities	213:236	Hydrogels with pH sensitivity and stable mechanical and antibacterial properties have many desirable qualities and broad applications.
34450146	10	18	theme	LIVE/DEAD	1277:1285	arg1	kit					1309:1311	The BacLight LIVE/DEAD membrane permeability kit	1264:1311	The BacLight LIVE/DEAD membrane permeability kit	1264:1311	The BacLight LIVE/DEAD membrane permeability kit is used to evaluate the membrane permeability of bacteria.
34450146	0	19	theme	bacterial	50:58	arg1	hydrogels					79:87	antibacterial bacterial cellulose/chitosan hydrogels	36:87	antibacterial bacterial cellulose/chitosan hydrogels	36:87	Preparation and characterization of antibacterial bacterial cellulose/chitosan hydrogels impregnated with silver sulfadiazine.
34450146	6	20	theme	mechanical	835:844	arg1	properties					846:855	mechanical properties	835:855	mechanical properties	835:855	The elemental composition, morphology, and mechanical properties of the hydrogels were characterized.
34450146	11	21	theme	biomedical	1521:1530	arg1	packaging					1443:1451	food packaging	1438:1451	food packaging	1438:1451	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	11	21	theme	biomedical	1521:1530	arg1	fields					1532:1537	clinical, biotechnological, and biomedical fields	1489:1537	clinical, biotechnological, and biomedical fields	1489:1537	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	1	22	theme	desirable	218:226	arg1	qualities					228:236	many desirable qualities	213:236	many desirable qualities	213:236	Hydrogels with pH sensitivity and stable mechanical and antibacterial properties have many desirable qualities and broad applications.
34450146	11	23	theme	food	1438:1441	arg1	packaging					1443:1451	food packaging	1438:1451	food packaging	1438:1451	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	11	23	theme	food	1438:1441	arg1	engineering					1461:1471	tissue engineering	1454:1471	tissue engineering	1454:1471	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	11	23	theme	food	1438:1441	arg1	delivery					1479:1486	drug delivery	1474:1486	drug delivery	1474:1486	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	11	23	theme	food	1438:1441	arg1	fields					1532:1537	clinical, biotechnological, and biomedical fields	1489:1537	clinical, biotechnological, and biomedical fields	1489:1537	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	4	24	theme	swelling	519:526	arg1	ratio					528:532	swelling ratio	519:532	swelling ratio	519:532	Micropore size, swelling ratio, pH- sensitivity, and gram positive and negative antibacterial properties were studied by disk diffusion and colony forming unit.
34450146	5	25	theme	X-ray	664:668	arg1	diffraction					670:680	X-ray diffraction	664:680	X-ray diffraction	664:680	X-ray diffraction confirmed the presence of amorphous and crystalline regions in the hydrogel matrix following addition of SSd.
34450146	2	26	theme	w/w	358:360	arg1	sulfadiazine					340:351	silver sulfadiazine	333:351	silver sulfadiazine (<1% w/w)	333:361	A hydrogel based on bacterial cellulose and chitosan, impregnated with silver sulfadiazine (<1% w/w), was prepared using glutaraldehyde as the crosslinking agent.
34450146	2	26	theme	w/w	358:360	arg1	%					356:356	<1% w/w	354:360	<1% w/w	354:360	A hydrogel based on bacterial cellulose and chitosan, impregnated with silver sulfadiazine (<1% w/w), was prepared using glutaraldehyde as the crosslinking agent.
34450146	7	27	theme	SSd	911:913	arg1	Incorporation					894:906	Incorporation	894:906	Incorporation of SSd into bacterial cellulose-chitosan hydrogels	894:957	Incorporation of SSd into bacterial cellulose-chitosan hydrogels significantly improved their mechanical and antibacterial properties.
34450146	5	28	dep	amorphous	708:716	arg1	regions					734:740	regions	734:740	regions	734:740	X-ray diffraction confirmed the presence of amorphous and crystalline regions in the hydrogel matrix following addition of SSd.
34450146	4	29	theme	antibacterial	583:595	arg1	properties					597:606	gram positive and negative antibacterial properties	556:606	gram positive and negative antibacterial properties	556:606	Micropore size, swelling ratio, pH- sensitivity, and gram positive and negative antibacterial properties were studied by disk diffusion and colony forming unit.
34450146	2	30	theme	crosslinking	405:416	arg1	glutaraldehyde					383:396	glutaraldehyde	383:396	glutaraldehyde	383:396	A hydrogel based on bacterial cellulose and chitosan, impregnated with silver sulfadiazine (<1% w/w), was prepared using glutaraldehyde as the crosslinking agent.
34450146	2	30	theme	crosslinking	405:416	arg1	agent					418:422	the crosslinking agent	401:422	the crosslinking agent	401:422	A hydrogel based on bacterial cellulose and chitosan, impregnated with silver sulfadiazine (<1% w/w), was prepared using glutaraldehyde as the crosslinking agent.
34450146	4	31	theme	negative	574:581	arg1	properties					597:606	gram positive and negative antibacterial properties	556:606	gram positive and negative antibacterial properties	556:606	Micropore size, swelling ratio, pH- sensitivity, and gram positive and negative antibacterial properties were studied by disk diffusion and colony forming unit.
34450146	8	32	theme	SSd-BC/Ch	1104:1112	arg1	hydrogels					1114:1122	SSd-BC/Ch hydrogels	1104:1122	SSd-BC/Ch hydrogels	1104:1122	The antibacterial activity against E. coli and S. aureus was evaluated and SSd-BC/Ch hydrogels are more toxic to S. aureus than to E. coli.
34450146	1	33	theme	broad	242:246	arg1	applications					248:259	broad applications	242:259	broad applications	242:259	Hydrogels with pH sensitivity and stable mechanical and antibacterial properties have many desirable qualities and broad applications.
34450146	1	34	with	Hydrogels	127:135	arg1	sensitivity					145:155	pH sensitivity	142:155	pH sensitivity	142:155	Hydrogels with pH sensitivity and stable mechanical and antibacterial properties have many desirable qualities and broad applications.
34450146	1	34	with	Hydrogels	127:135	arg1	properties					197:206	stable mechanical and antibacterial properties	161:206	stable mechanical and antibacterial properties	161:206	Hydrogels with pH sensitivity and stable mechanical and antibacterial properties have many desirable qualities and broad applications.
34450146	5	35	theme	hydrogel	749:756	arg1	matrix					758:763	the hydrogel matrix	745:763	the hydrogel matrix	745:763	X-ray diffraction confirmed the presence of amorphous and crystalline regions in the hydrogel matrix following addition of SSd.
34450146	1	36	theme	pH	142:143	arg1	sensitivity					145:155	pH sensitivity	142:155	pH sensitivity	142:155	Hydrogels with pH sensitivity and stable mechanical and antibacterial properties have many desirable qualities and broad applications.
34450146	8	37	theme	antibacterial	1033:1045	arg1	activity					1047:1054	The antibacterial activity	1029:1054	The antibacterial activity against E. coli and S. aureus	1029:1084	The antibacterial activity against E. coli and S. aureus was evaluated and SSd-BC/Ch hydrogels are more toxic to S. aureus than to E. coli.
34450146	3	38	theme	SSd	441:443	arg1	presence					429:436	The presence	425:436	The presence of SSd	425:443	The presence of SSd was confirmed by Fourier transform infrared spectroscopy.
34450146	10	39	theme	membrane	1337:1344	arg1	permeability					1346:1357	the membrane permeability	1333:1357	the membrane permeability of bacteria	1333:1369	The BacLight LIVE/DEAD membrane permeability kit is used to evaluate the membrane permeability of bacteria.
34450146	2	40	theme	bacterial	282:290	arg1	cellulose					292:300	bacterial cellulose	282:300	bacterial cellulose	282:300	A hydrogel based on bacterial cellulose and chitosan, impregnated with silver sulfadiazine (<1% w/w), was prepared using glutaraldehyde as the crosslinking agent.
34450146	0	41	theme	antibacterial	36:48	arg1	hydrogels					79:87	antibacterial bacterial cellulose/chitosan hydrogels	36:87	antibacterial bacterial cellulose/chitosan hydrogels	36:87	Preparation and characterization of antibacterial bacterial cellulose/chitosan hydrogels impregnated with silver sulfadiazine.
34450146	4	42	theme	Micropore	503:511	arg1	size					513:516	Micropore size	503:516	Micropore size	503:516	Micropore size, swelling ratio, pH- sensitivity, and gram positive and negative antibacterial properties were studied by disk diffusion and colony forming unit.
34450146	11	43	theme	biotechnological	1499:1514	arg1	packaging					1443:1451	food packaging	1438:1451	food packaging	1438:1451	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	11	43	theme	biotechnological	1499:1514	arg1	fields					1532:1537	clinical, biotechnological, and biomedical fields	1489:1537	clinical, biotechnological, and biomedical fields	1489:1537	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	9	44	theme	bacterial	1193:1201	arg1	morphology					1203:1212	bacterial morphology	1193:1212	bacterial morphology	1193:1212	We use FESEM to observe bacterial morphology before and after exposure to SSd-BC/Ch hydrogels.
34450146	5	45	from	presence	696:703	arg1	matrix					758:763	the hydrogel matrix	745:763	the hydrogel matrix	745:763	X-ray diffraction confirmed the presence of amorphous and crystalline regions in the hydrogel matrix following addition of SSd.
34450146	0	46	theme	hydrogels	79:87	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of antibacterial bacterial cellulose/chitosan hydrogels impregnated with silver sulfadiazine.
34450146	0	46	theme	hydrogels	79:87	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of antibacterial bacterial cellulose/chitosan hydrogels impregnated with silver sulfadiazine.
34450146	3	47	dep	Fourier	462:468	arg1	transform					470:478	transform	470:478	transform infrared spectroscopy	470:500	The presence of SSd was confirmed by Fourier transform infrared spectroscopy.
34450146	11	48	theme	promising	1412:1420	arg1	applications					1422:1433	many promising applications	1407:1433	many promising applications	1407:1433	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	0	49	theme	cellulose/chitosan	60:77	arg1	hydrogels					79:87	antibacterial bacterial cellulose/chitosan hydrogels	36:87	antibacterial bacterial cellulose/chitosan hydrogels	36:87	Preparation and characterization of antibacterial bacterial cellulose/chitosan hydrogels impregnated with silver sulfadiazine.
34450146	5	50	theme	crystalline	722:732	arg1	presence					696:703	the presence	692:703	the presence of amorphous and crystalline regions in the hydrogel matrix	692:763	X-ray diffraction confirmed the presence of amorphous and crystalline regions in the hydrogel matrix following addition of SSd.
34450146	3	51	dep	transform	470:478	arg1	infrared					480:487	infrared	480:487	transform infrared spectroscopy	470:500	The presence of SSd was confirmed by Fourier transform infrared spectroscopy.
34450146	6	52	theme	elemental	796:804	arg1	composition					806:816	The elemental composition	792:816	The elemental composition	792:816	The elemental composition, morphology, and mechanical properties of the hydrogels were characterized.
34450146	5	53	attach	presence	696:703	arg2	amorphous					708:716	amorphous	708:716	amorphous	708:716	X-ray diffraction confirmed the presence of amorphous and crystalline regions in the hydrogel matrix following addition of SSd.
34450146	5	53	attach	presence	696:703	arg1	matrix					758:763	the hydrogel matrix	745:763	the hydrogel matrix	745:763	X-ray diffraction confirmed the presence of amorphous and crystalline regions in the hydrogel matrix following addition of SSd.
34450146	5	53	attach	presence	696:703	arg2	crystalline					722:732	crystalline	722:732	crystalline	722:732	X-ray diffraction confirmed the presence of amorphous and crystalline regions in the hydrogel matrix following addition of SSd.
34450146	4	54	theme	positive	561:568	arg1	properties					597:606	gram positive and negative antibacterial properties	556:606	gram positive and negative antibacterial properties	556:606	Micropore size, swelling ratio, pH- sensitivity, and gram positive and negative antibacterial properties were studied by disk diffusion and colony forming unit.
34450146	1	55	theme	stable	161:166	arg1	properties					197:206	stable mechanical and antibacterial properties	161:206	stable mechanical and antibacterial properties	161:206	Hydrogels with pH sensitivity and stable mechanical and antibacterial properties have many desirable qualities and broad applications.
34450146	7	56	theme	antibacterial	1003:1015	arg1	properties					1017:1026	their mechanical and antibacterial properties	982:1026	their mechanical and antibacterial properties	982:1026	Incorporation of SSd into bacterial cellulose-chitosan hydrogels significantly improved their mechanical and antibacterial properties.
34450146	10	57	theme	BacLight	1268:1275	arg1	kit					1309:1311	The BacLight LIVE/DEAD membrane permeability kit	1264:1311	The BacLight LIVE/DEAD membrane permeability kit	1264:1311	The BacLight LIVE/DEAD membrane permeability kit is used to evaluate the membrane permeability of bacteria.
34450146	10	58	theme	bacteria	1362:1369	arg1	permeability					1346:1357	the membrane permeability	1333:1357	the membrane permeability of bacteria	1333:1369	The BacLight LIVE/DEAD membrane permeability kit is used to evaluate the membrane permeability of bacteria.
34450146	1	59	theme	mechanical	168:177	arg1	properties					197:206	stable mechanical and antibacterial properties	161:206	stable mechanical and antibacterial properties	161:206	Hydrogels with pH sensitivity and stable mechanical and antibacterial properties have many desirable qualities and broad applications.
34450146	10	60	used	used	1316:1319	arg2	kit					1309:1311	The BacLight LIVE/DEAD membrane permeability kit	1264:1311	The BacLight LIVE/DEAD membrane permeability kit	1264:1311	The BacLight LIVE/DEAD membrane permeability kit is used to evaluate the membrane permeability of bacteria.
34450146	7	61	theme	mechanical	988:997	arg1	properties					1017:1026	their mechanical and antibacterial properties	982:1026	their mechanical and antibacterial properties	982:1026	Incorporation of SSd into bacterial cellulose-chitosan hydrogels significantly improved their mechanical and antibacterial properties.
34450146	11	62	theme	clinical	1489:1496	arg1	packaging					1443:1451	food packaging	1438:1451	food packaging	1438:1451	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	11	62	theme	clinical	1489:1496	arg1	fields					1532:1537	clinical, biotechnological, and biomedical fields	1489:1537	clinical, biotechnological, and biomedical fields	1489:1537	These antibacterial hydrogels have many promising applications in food packaging, tissue engineering, drug delivery, clinical, biotechnological, and biomedical fields.
34450146	4	63	theme	pH-	535:537	arg1	sensitivity					539:549	pH- sensitivity	535:549	pH- sensitivity	535:549	Micropore size, swelling ratio, pH- sensitivity, and gram positive and negative antibacterial properties were studied by disk diffusion and colony forming unit.
34450146	1	64	theme	antibacterial	183:195	arg1	properties					197:206	stable mechanical and antibacterial properties	161:206	stable mechanical and antibacterial properties	161:206	Hydrogels with pH sensitivity and stable mechanical and antibacterial properties have many desirable qualities and broad applications.
32248230	1	0	theme	milk	244:247	arg1	HMOs					267:270	HMOs	267:270	HMOs	267:270	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	1	0	theme	milk	244:247	arg1	oligosaccharides					249:264	free human milk oligosaccharides	233:264	free human milk oligosaccharides (HMOs)	233:271	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	6	1	contain	contain	1144:1150	arg2	HMOs					1166:1169	80 HMOs	1163:1169	80 HMOs	1163:1169	We observed that these samples contain on average 80 HMOs, with the highest permethylated masses detected being >5000 mass units.
32248230	6	1	contain	contain	1144:1150	arg1	samples					1136:1142	these samples	1130:1142	these samples	1130:1142	We observed that these samples contain on average 80 HMOs, with the highest permethylated masses detected being >5000 mass units.
32248230	6	1	contain	contain	1144:1150	arg1	average					1155:1161	average	1155:1161	average	1155:1161	We observed that these samples contain on average 80 HMOs, with the highest permethylated masses detected being >5000 mass units.
32248230	6	1	contain	contain	1144:1150	arg2	samples					1136:1142	these samples	1130:1142	these samples	1130:1142	We observed that these samples contain on average 80 HMOs, with the highest permethylated masses detected being >5000 mass units.
32248230	8	2	gly	sialylated	1548:1557	arg1	HMOs					1578:1581	sialylated and/or fucosylated HMOs	1548:1581	sialylated and/or fucosylated HMOs	1548:1581	Our ultimate goal is to create a simple, high-throughput method, which can be used for full characterization of sialylated and/or fucosylated HMOs.
32248230	3	3	theme	milk	517:520	arg1	composition					522:532	breast milk composition	510:532	breast milk composition	510:532	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	7	4	gly	sialylated	1419:1428	arg1	HMOs					1430:1433	higher molecular weight sialylated HMOs	1395:1433	higher molecular weight sialylated HMOs	1395:1433	Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
32248230	7	5	theme	weight	1412:1417	arg1	HMOs					1430:1433	higher molecular weight sialylated HMOs	1395:1433	higher molecular weight sialylated HMOs	1395:1433	Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
32248230	9	6	theme	milk	1681:1684	arg1	composition					1686:1696	human milk composition	1675:1696	human milk composition	1675:1696	These results demonstrate how current analytical techniques can be applied to characterize human milk composition, providing new tools to help the scientific community shed new light on the impact of HMOs during infant development.
32248230	7	7	theme	higher	1395:1400	arg1	weight					1412:1417	higher molecular weight	1395:1417	higher molecular weight sialylated HMOs	1395:1433	Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
32248230	6	8	theme	mass	1231:1234	arg1	units					1236:1240	>5000 mass units	1225:1240	>5000 mass units	1225:1240	We observed that these samples contain on average 80 HMOs, with the highest permethylated masses detected being >5000 mass units.
32248230	1	9	theme	complex	176:182	arg1	oligosaccharides					249:264	free human milk oligosaccharides	233:264	free human milk oligosaccharides (HMOs)	233:271	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	1	9	theme	complex	176:182	arg1	repertoire					219:228	a diverse repertoire	209:228	a diverse repertoire of free human milk oligosaccharides (HMOs)	209:271	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	1	9	theme	complex	176:182	arg1	carbohydrates					184:196	complex carbohydrates	176:196	complex carbohydrates	176:196	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	9	10	theme	new	1709:1711	arg1	tools					1713:1717	new tools	1709:1717	new tools	1709:1717	These results demonstrate how current analytical techniques can be applied to characterize human milk composition, providing new tools to help the scientific community shed new light on the impact of HMOs during infant development.
32248230	6	11	theme	>5000	1225:1229	arg1	units					1236:1240	>5000 mass units	1225:1240	>5000 mass units	1225:1240	We observed that these samples contain on average 80 HMOs, with the highest permethylated masses detected being >5000 mass units.
32248230	4	12	theme	human	610:614	arg1	samples					621:627	human milk samples	610:627	human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children	610:730	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	4	13	theme	tandem	885:890	arg1	LC-MS/MS					911:918	LC-MS/MS	911:918	LC-MS/MS	911:918	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	4	13	theme	tandem	885:890	arg1	spectrometry					897:908	high-resolution tandem mass spectrometry	869:908	high-resolution tandem mass spectrometry (LC-MS/MS) analysis	869:928	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	7	14	theme	large	1363:1367	arg1	arrays					1369:1374	large arrays	1363:1374	large arrays of HMOs, including higher molecular weight sialylated HMOs	1363:1433	Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
32248230	3	15	theme	HMO	551:553	arg1	diversity					555:563	HMO diversity	551:563	HMO diversity	551:563	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	1	16	theme	rich	117:120	arg1	milk					95:98	Human breast milk	82:98	Human breast milk	82:98	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	1	16	theme	rich	117:120	arg1	biofluid					134:141	an incredibly rich and complex biofluid	103:141	an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs)	103:271	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	4	17	theme	spectrometry	897:908	arg1	analysis					921:928	high-resolution tandem mass spectrometry (LC-MS/MS) analysis	869:928	high-resolution tandem mass spectrometry (LC-MS/MS) analysis	869:928	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	6	18	theme	permethylated	1189:1201	arg1	masses					1203:1208	the highest permethylated masses	1177:1208	the highest permethylated masses detected being >5000 mass units	1177:1240	We observed that these samples contain on average 80 HMOs, with the highest permethylated masses detected being >5000 mass units.
32248230	3	19	theme	utmost	586:591	arg1	relevance					593:601	utmost relevance	586:601	utmost relevance	586:601	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	1	20	theme	complex	126:132	arg1	milk					95:98	Human breast milk	82:98	Human breast milk	82:98	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	1	20	theme	complex	126:132	arg1	biofluid					134:141	an incredibly rich and complex biofluid	103:141	an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs)	103:271	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	0	21	theme	milk	59:62	arg1	oligosaccharides					64:79	human milk oligosaccharides	53:79	human milk oligosaccharides	53:79	New strategies for profiling and characterization of human milk oligosaccharides.
32248230	9	22	theme	new	1757:1759	arg1	light					1761:1765	new light	1757:1765	new light	1757:1765	These results demonstrate how current analytical techniques can be applied to characterize human milk composition, providing new tools to help the scientific community shed new light on the impact of HMOs during infant development.
32248230	4	23	theme	mass	892:895	arg1	LC-MS/MS					911:918	LC-MS/MS	911:918	LC-MS/MS	911:918	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	4	23	theme	mass	892:895	arg1	spectrometry					897:908	high-resolution tandem mass spectrometry	869:908	high-resolution tandem mass spectrometry (LC-MS/MS) analysis	869:928	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	4	24	theme	mothers	658:664	arg1	cohort					636:641	a cohort	634:641	a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children	634:730	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	5	25	theme	HMOs	1085:1088	arg1	predominance					1042:1053	a predominance	1040:1053	a predominance of fucosylated and sialylated HMOs over nonmodified HMOs	1040:1110	This approach identified over 100 different glycoforms and showed a wide diversity of milk composition, with a predominance of fucosylated and sialylated HMOs over nonmodified HMOs.
32248230	3	26	theme	broad	422:426	arg1	variety					428:434	the broad variety	418:434	the broad variety of beneficial effects of HMOs	418:464	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	3	26	theme	broad	422:426	arg1	effects					450:456	beneficial effects	439:456	beneficial effects of HMOs	439:464	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	3	26	theme	broad	422:426	arg1	factors					490:496	factors	490:496	factors that affect breast milk composition	490:532	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	5	27	theme	nonmodified	1095:1105	arg1	HMOs					1107:1110	nonmodified HMOs	1095:1110	nonmodified HMOs	1095:1110	This approach identified over 100 different glycoforms and showed a wide diversity of milk composition, with a predominance of fucosylated and sialylated HMOs over nonmodified HMOs.
32248230	1	28	theme	Human	82:86	arg1	milk					95:98	Human breast milk	82:98	Human breast milk	82:98	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	1	28	theme	Human	82:86	arg1	biofluid					134:141	an incredibly rich and complex biofluid	103:141	an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs)	103:271	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	9	29	theme	HMOs	1784:1787	arg1	impact					1774:1779	the impact	1770:1779	the impact of HMOs during infant development	1770:1813	These results demonstrate how current analytical techniques can be applied to characterize human milk composition, providing new tools to help the scientific community shed new light on the impact of HMOs during infant development.
32248230	2	30	theme	bacterial	353:361	arg1	strains					363:369	bacterial strains	353:369	bacterial strains associated with numerous benefits	353:403	Strikingly, HMOs are not digested by the infant but function as prebiotics for bacterial strains associated with numerous benefits.
32248230	0	31	theme	New	0:2	arg1	strategies					4:13	New strategies	0:13	New strategies for profiling and characterization of human milk oligosaccharides.	0:80	New strategies for profiling and characterization of human milk oligosaccharides.
32248230	8	32	dep	simple	1469:1474	arg1	high-throughput					1477:1491	high-throughput	1477:1491	high-throughput	1477:1491	Our ultimate goal is to create a simple, high-throughput method, which can be used for full characterization of sialylated and/or fucosylated HMOs.
32248230	9	33	theme	infant	1796:1801	arg1	development					1803:1813	infant development	1796:1813	infant development	1796:1813	These results demonstrate how current analytical techniques can be applied to characterize human milk composition, providing new tools to help the scientific community shed new light on the impact of HMOs during infant development.
32248230	3	34	theme	effects	450:456	arg1	number					480:485	the vast number	471:485	the vast number of factors that affect breast milk composition	471:532	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	3	34	theme	effects	450:456	arg1	variety					428:434	the broad variety	418:434	the broad variety of beneficial effects of HMOs	418:464	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	3	34	theme	effects	450:456	arg1	effects					450:456	beneficial effects	439:456	beneficial effects of HMOs	439:464	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	3	34	theme	effects	450:456	arg1	factors					490:496	factors	490:496	factors that affect breast milk composition	490:532	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	2	35	theme	numerous	387:394	arg1	benefits					396:403	numerous benefits	387:403	numerous benefits	387:403	Strikingly, HMOs are not digested by the infant but function as prebiotics for bacterial strains associated with numerous benefits.
32248230	7	36	dep	separation	1305:1314	arg1	the					1301:1303	the	1301:1303	the	1301:1303	Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
32248230	8	37	theme	sialylated	1548:1557	arg1	HMOs					1578:1581	sialylated and/or fucosylated HMOs	1548:1581	sialylated and/or fucosylated HMOs	1548:1581	Our ultimate goal is to create a simple, high-throughput method, which can be used for full characterization of sialylated and/or fucosylated HMOs.
32248230	5	38	theme	composition	1022:1032	arg1	diversity					1004:1012	a wide diversity	997:1012	a wide diversity of milk composition	997:1032	This approach identified over 100 different glycoforms and showed a wide diversity of milk composition, with a predominance of fucosylated and sialylated HMOs over nonmodified HMOs.
32248230	5	39	gly	fucosylated	1058:1068	arg1	HMOs					1085:1088	fucosylated and sialylated HMOs	1058:1088	fucosylated and sialylated HMOs over nonmodified HMOs	1058:1110	This approach identified over 100 different glycoforms and showed a wide diversity of milk composition, with a predominance of fucosylated and sialylated HMOs over nonmodified HMOs.
32248230	8	40	theme	fucosylated	1566:1576	arg1	HMOs					1578:1581	sialylated and/or fucosylated HMOs	1548:1581	sialylated and/or fucosylated HMOs	1548:1581	Our ultimate goal is to create a simple, high-throughput method, which can be used for full characterization of sialylated and/or fucosylated HMOs.
32248230	3	41	theme	HMOs	461:464	arg1	effects					450:456	beneficial effects	439:456	beneficial effects of HMOs	439:464	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	1	42	theme	diverse	211:217	arg1	HMOs					267:270	HMOs	267:270	HMOs	267:270	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	1	42	theme	diverse	211:217	arg1	oligosaccharides					249:264	free human milk oligosaccharides	233:264	free human milk oligosaccharides (HMOs)	233:271	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	1	42	theme	diverse	211:217	arg1	repertoire					219:228	a diverse repertoire	209:228	a diverse repertoire of free human milk oligosaccharides (HMOs)	209:271	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	9	43	theme	current	1614:1620	arg1	techniques					1633:1642	current analytical techniques	1614:1642	current analytical techniques	1614:1642	These results demonstrate how current analytical techniques can be applied to characterize human milk composition, providing new tools to help the scientific community shed new light on the impact of HMOs during infant development.
32248230	5	44	gly	sialylated	1074:1083	arg1	HMOs					1085:1088	fucosylated and sialylated HMOs	1058:1088	fucosylated and sialylated HMOs over nonmodified HMOs	1058:1110	This approach identified over 100 different glycoforms and showed a wide diversity of milk composition, with a predominance of fucosylated and sialylated HMOs over nonmodified HMOs.
32248230	4	45	theme	milk	762:765	arg1	composition					783:793	breast milk oligosaccharide composition	755:793	breast milk oligosaccharide composition	755:793	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	5	46	theme	wide	999:1002	arg1	diversity					1004:1012	a wide diversity	997:1012	a wide diversity of milk composition	997:1032	This approach identified over 100 different glycoforms and showed a wide diversity of milk composition, with a predominance of fucosylated and sialylated HMOs over nonmodified HMOs.
32248230	3	47	theme	vast	475:478	arg1	number					480:485	the vast number	471:485	the vast number of factors that affect breast milk composition	471:532	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	1	48	theme	human	238:242	arg1	HMOs					267:270	HMOs	267:270	HMOs	267:270	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	1	48	theme	human	238:242	arg1	oligosaccharides					249:264	free human milk oligosaccharides	233:264	free human milk oligosaccharides (HMOs)	233:271	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	4	49	theme	liquid	834:839	arg1	chromatography					841:854	liquid chromatography	834:854	liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis	834:928	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	3	50	theme	breast	510:515	arg1	composition					522:532	breast milk composition	510:532	breast milk composition	510:532	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	4	51	from	cohort	636:641	arg1	samples					621:627	human milk samples	610:627	human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children	610:730	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	1	52	theme	oligosaccharides	249:264	arg1	HMOs					267:270	HMOs	267:270	HMOs	267:270	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	1	52	theme	oligosaccharides	249:264	arg1	oligosaccharides					249:264	free human milk oligosaccharides	233:264	free human milk oligosaccharides (HMOs)	233:271	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	1	52	theme	oligosaccharides	249:264	arg1	repertoire					219:228	a diverse repertoire	209:228	a diverse repertoire of free human milk oligosaccharides (HMOs)	209:271	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	9	53	theme	human	1675:1679	arg1	composition					1686:1696	human milk composition	1675:1696	human milk composition	1675:1696	These results demonstrate how current analytical techniques can be applied to characterize human milk composition, providing new tools to help the scientific community shed new light on the impact of HMOs during infant development.
32248230	7	54	theme	sialylated	1419:1428	arg1	HMOs					1430:1433	higher molecular weight sialylated HMOs	1395:1433	higher molecular weight sialylated HMOs	1395:1433	Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
32248230	4	55	theme	milk	616:619	arg1	samples					621:627	human milk samples	610:627	human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children	610:730	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	7	56	theme	molecular	1402:1410	arg1	weight					1412:1417	higher molecular weight	1395:1417	higher molecular weight sialylated HMOs	1395:1433	Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
32248230	8	57	theme	ultimate	1440:1447	arg1	goal					1449:1452	Our ultimate goal	1436:1452	Our ultimate goal	1436:1452	Our ultimate goal is to create a simple, high-throughput method, which can be used for full characterization of sialylated and/or fucosylated HMOs.
32248230	5	58	theme	fucosylated	1058:1068	arg1	HMOs					1085:1088	fucosylated and sialylated HMOs	1058:1088	fucosylated and sialylated HMOs over nonmodified HMOs	1058:1110	This approach identified over 100 different glycoforms and showed a wide diversity of milk composition, with a predominance of fucosylated and sialylated HMOs over nonmodified HMOs.
32248230	3	59	theme	diversity	555:563	arg1	analysis					539:546	the analysis	535:546	the analysis of HMO diversity and complexity	535:578	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	7	60	theme	HMOs	1379:1382	arg1	arrays					1369:1374	large arrays	1363:1374	large arrays of HMOs, including higher molecular weight sialylated HMOs	1363:1433	Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
32248230	5	61	theme	sialylated	1074:1083	arg1	HMOs					1085:1088	fucosylated and sialylated HMOs	1058:1088	fucosylated and sialylated HMOs over nonmodified HMOs	1058:1110	This approach identified over 100 different glycoforms and showed a wide diversity of milk composition, with a predominance of fucosylated and sialylated HMOs over nonmodified HMOs.
32248230	4	62	theme	high-resolution	869:883	arg1	LC-MS/MS					911:918	LC-MS/MS	911:918	LC-MS/MS	911:918	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	4	62	theme	high-resolution	869:883	arg1	spectrometry					897:908	high-resolution tandem mass spectrometry	869:908	high-resolution tandem mass spectrometry (LC-MS/MS) analysis	869:928	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	7	63	theme	arrays	1369:1374	arg1	quantitation					1347:1358	relative quantitation	1338:1358	relative quantitation	1338:1358	Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
32248230	7	63	theme	arrays	1369:1374	arg1	separation					1305:1314	separation	1305:1314	separation	1305:1314	Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
32248230	7	63	theme	arrays	1369:1374	arg1	characterization					1317:1332	characterization	1317:1332	characterization	1317:1332	Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
32248230	9	64	theme	scientific	1731:1740	arg1	community					1742:1750	the scientific community	1727:1750	the scientific community	1727:1750	These results demonstrate how current analytical techniques can be applied to characterize human milk composition, providing new tools to help the scientific community shed new light on the impact of HMOs during infant development.
32248230	8	65	theme	simple	1469:1474	arg1	method					1493:1498	a simple, high-throughput method	1467:1498	a simple, high-throughput method	1467:1498	Our ultimate goal is to create a simple, high-throughput method, which can be used for full characterization of sialylated and/or fucosylated HMOs.
32248230	6	66	theme	highest	1181:1187	arg1	masses					1203:1208	the highest permethylated masses	1177:1208	the highest permethylated masses detected being >5000 mass units	1177:1240	We observed that these samples contain on average 80 HMOs, with the highest permethylated masses detected being >5000 mass units.
32248230	0	67	theme	oligosaccharides	64:79	arg1	characterization					33:48	characterization	33:48	characterization	33:48	New strategies for profiling and characterization of human milk oligosaccharides.
32248230	0	67	theme	oligosaccharides	64:79	arg1	profiling					19:27	profiling	19:27	profiling	19:27	New strategies for profiling and characterization of human milk oligosaccharides.
32248230	3	68	theme	complexity	569:578	arg1	analysis					539:546	the analysis	535:546	the analysis of HMO diversity and complexity	535:578	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	7	69	theme	relative	1338:1345	arg1	quantitation					1347:1358	relative quantitation	1338:1358	relative quantitation	1338:1358	Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
32248230	4	70	theme	Bangladeshi	646:656	arg1	mothers					658:664	Bangladeshi mothers	646:664	Bangladeshi mothers participating in a study on malnutrition and stunting in children	646:730	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	8	71	used	used	1514:1517	arg2	method					1493:1498	a simple, high-throughput method	1467:1498	a simple, high-throughput method	1467:1498	Our ultimate goal is to create a simple, high-throughput method, which can be used for full characterization of sialylated and/or fucosylated HMOs.
32248230	5	72	theme	different	965:973	arg1	glycoforms					975:984	100 different glycoforms	961:984	100 different glycoforms	961:984	This approach identified over 100 different glycoforms and showed a wide diversity of milk composition, with a predominance of fucosylated and sialylated HMOs over nonmodified HMOs.
32248230	1	73	theme	breast	88:93	arg1	milk					95:98	Human breast milk	82:98	Human breast milk	82:98	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	1	73	theme	breast	88:93	arg1	biofluid					134:141	an incredibly rich and complex biofluid	103:141	an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs)	103:271	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	8	74	theme	full	1523:1526	arg1	characterization					1528:1543	full characterization	1523:1543	full characterization of sialylated and/or fucosylated HMOs	1523:1581	Our ultimate goal is to create a simple, high-throughput method, which can be used for full characterization of sialylated and/or fucosylated HMOs.
32248230	8	75	gly	fucosylated	1566:1576	arg1	HMOs					1578:1581	sialylated and/or fucosylated HMOs	1548:1581	sialylated and/or fucosylated HMOs	1548:1581	Our ultimate goal is to create a simple, high-throughput method, which can be used for full characterization of sialylated and/or fucosylated HMOs.
32248230	7	76	theme	implemented	1268:1278	arg1	method					1280:1285	an easily implemented method	1258:1285	an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs	1258:1433	Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs.
32248230	4	77	theme	oligosaccharide	767:781	arg1	composition					783:793	breast milk oligosaccharide composition	755:793	breast milk oligosaccharide composition	755:793	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	3	78	theme	beneficial	439:448	arg1	effects					450:456	beneficial effects	439:456	beneficial effects of HMOs	439:464	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	0	79	theme	human	53:57	arg1	oligosaccharides					64:79	human milk oligosaccharides	53:79	human milk oligosaccharides	53:79	New strategies for profiling and characterization of human milk oligosaccharides.
32248230	5	80	theme	milk	1017:1020	arg1	composition					1022:1032	milk composition	1017:1032	milk composition	1017:1032	This approach identified over 100 different glycoforms and showed a wide diversity of milk composition, with a predominance of fucosylated and sialylated HMOs over nonmodified HMOs.
32248230	8	81	theme	HMOs	1578:1581	arg1	characterization					1528:1543	full characterization	1523:1543	full characterization of sialylated and/or fucosylated HMOs	1523:1581	Our ultimate goal is to create a simple, high-throughput method, which can be used for full characterization of sialylated and/or fucosylated HMOs.
32248230	9	82	theme	analytical	1622:1631	arg1	techniques					1633:1642	current analytical techniques	1614:1642	current analytical techniques	1614:1642	These results demonstrate how current analytical techniques can be applied to characterize human milk composition, providing new tools to help the scientific community shed new light on the impact of HMOs during infant development.
32248230	4	83	theme	breast	755:760	arg1	composition					783:793	breast milk oligosaccharide composition	755:793	breast milk oligosaccharide composition	755:793	Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis.
32248230	3	84	theme	factors	490:496	arg1	number					480:485	the vast number	471:485	the vast number of factors that affect breast milk composition	471:532	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	3	84	theme	factors	490:496	arg1	variety					428:434	the broad variety	418:434	the broad variety of beneficial effects of HMOs	418:464	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	3	84	theme	factors	490:496	arg1	effects					450:456	beneficial effects	439:456	beneficial effects of HMOs	439:464	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	3	84	theme	factors	490:496	arg1	factors					490:496	factors	490:496	factors that affect breast milk composition	490:532	Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance.
32248230	1	85	theme	free	233:236	arg1	HMOs					267:270	HMOs	267:270	HMOs	267:270	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
32248230	1	85	theme	free	233:236	arg1	oligosaccharides					249:264	free human milk oligosaccharides	233:264	free human milk oligosaccharides (HMOs)	233:271	Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs).
34375147	12	0	theme	potential	2125:2133	arg1	candidate					2135:2143	a potential candidate	2123:2143	a potential candidate for peripheral nerve regeneration	2123:2177	Thus, we provide a potential candidate for peripheral nerve regeneration.
34375147	7	1	theme	sciatic	1288:1294	arg1	injury					1302:1307	repair sciatic nerve injury	1281:1307	repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs)	1281:1418	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	3	2	theme	absorption	551:560	arg1	spectrometer					479:490	a Fourier infrared spectrometer	460:490	a Fourier infrared spectrometer	460:490	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	2	theme	absorption	551:560	arg1	assay					562:566	water absorption assay	545:566	water absorption assay	545:566	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	2	3	theme	composite	319:327	arg1	HCSS					338:341	HCSS	338:341	HCSS	338:341	Herein, a series of hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS) were fabricated by a freeze-drying technique.
34375147	2	3	theme	composite	319:327	arg1	sponges					329:335	hydroxypropyl chitosan/soy protein isolate composite sponges	276:335	hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS)	276:342	Herein, a series of hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS) were fabricated by a freeze-drying technique.
34375147	4	4	theme	high	712:715	arg1	ratio					733:737	a high water retention ratio	710:737	a high water retention ratio	710:737	The results indicated that HCSS exhibited an interconnected porous microstructure and a high water retention ratio with the increase in soy protein isolate (SPI) content.
34375147	2	5	theme	protein	303:309	arg1	HCSS					338:341	HCSS	338:341	HCSS	338:341	Herein, a series of hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS) were fabricated by a freeze-drying technique.
34375147	2	5	theme	protein	303:309	arg1	sponges					329:335	hydroxypropyl chitosan/soy protein isolate composite sponges	276:335	hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS)	276:342	Herein, a series of hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS) were fabricated by a freeze-drying technique.
34375147	6	6	theme	TGF-β	1148:1152	arg1	times					1164:1168	three times	1158:1168	three times higher than that of the control group	1158:1206	In addition, HCSS-50 could significantly promote the expression of neuro-related factors; for example, the expression of TGF-β was three times higher than that of the control group.
34375147	6	6	theme	TGF-β	1148:1152	arg1	expression					1134:1143	the expression	1130:1143	the expression of TGF-β	1130:1152	In addition, HCSS-50 could significantly promote the expression of neuro-related factors; for example, the expression of TGF-β was three times higher than that of the control group.
34375147	4	7	theme	retention	723:731	arg1	ratio					733:737	a high water retention ratio	710:737	a high water retention ratio	710:737	The results indicated that HCSS exhibited an interconnected porous microstructure and a high water retention ratio with the increase in soy protein isolate (SPI) content.
34375147	10	8	theme	statement	1844:1852	arg1	repair					1871:1876	Impact statement Peripheral nerve repair	1837:1876	Impact statement Peripheral nerve repair	1837:1876	Impact statement Peripheral nerve repair is of paramount significance in the clinical.
34375147	5	9	theme	cells	924:928	arg1	secretion					938:946	the secretion	934:946	the secretion of neuro-related factors	934:971	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	5	9	theme	cells	924:928	arg1	proliferation					901:913	the proliferation	897:913	the proliferation of RSC96 cells	897:928	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	8	10	theme	BMSC-derived	1496:1507	arg1	SCs					1509:1511	the constructed HCSS-based conduit accompanying BMSC-derived SCs	1448:1511	the constructed HCSS-based conduit accompanying BMSC-derived SCs	1448:1511	The results suggested that the constructed HCSS-based conduit accompanying BMSC-derived SCs could effectively promote axonal regeneration and upregulate the expression of neuro-related factors such as Krox20, Zeb2, and GAP43.
34375147	6	11	theme	control	1194:1200	arg1	group					1202:1206	the control group	1190:1206	the control group	1190:1206	In addition, HCSS-50 could significantly promote the expression of neuro-related factors; for example, the expression of TGF-β was three times higher than that of the control group.
34375147	4	12	theme	porous	684:689	arg1	microstructure					691:704	an interconnected porous microstructure	666:704	an interconnected porous microstructure	666:704	The results indicated that HCSS exhibited an interconnected porous microstructure and a high water retention ratio with the increase in soy protein isolate (SPI) content.
34375147	3	13	theme	compressive	596:606	arg1	spectrometer					479:490	a Fourier infrared spectrometer	460:490	a Fourier infrared spectrometer	460:490	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	13	theme	compressive	596:606	arg1	assay					617:621	compressive strength assay	596:621	compressive strength assay	596:621	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	1	14	theme	peripheral	225:234	arg1	regeneration					242:253	peripheral nerve regeneration	225:253	peripheral nerve regeneration	225:253	Designing scaffolds, with optimized microstructure and function for promoting the release of neuro-related factors, is significant in peripheral nerve regeneration.
34375147	8	15	theme	conduit	1475:1481	arg1	SCs					1509:1511	the constructed HCSS-based conduit accompanying BMSC-derived SCs	1448:1511	the constructed HCSS-based conduit accompanying BMSC-derived SCs	1448:1511	The results suggested that the constructed HCSS-based conduit accompanying BMSC-derived SCs could effectively promote axonal regeneration and upregulate the expression of neuro-related factors such as Krox20, Zeb2, and GAP43.
34375147	11	16	theme	isolate	1981:1987	arg1	conduit					1989:1995	a hydroxypropyl chitosan/soy protein isolate conduit	1944:1995	a hydroxypropyl chitosan/soy protein isolate conduit	1944:1995	This work describes a hydroxypropyl chitosan/soy protein isolate conduit, which could effectively promote axonal regeneration and upregulate the expression of neuro-related factors.
34375147	9	17	theme	nerve	1680:1684	arg1	system					1694:1699	a newly engineered nerve conduit system	1661:1699	a newly engineered nerve conduit system	1661:1699	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	5	18	theme	%	863:863	arg1	content					869:875	50% SPI content	861:875	50% SPI content	861:875	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	5	19	contain	containing	850:859	arg2	content					869:875	50% SPI content	861:875	50% SPI content	861:875	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	5	19	contain	containing	850:859	arg1	HCSS-50					842:848	the HCSS-50	838:848	the HCSS-50 containing 50% SPI content	838:875	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	7	20	theme	cells	1408:1412	arg1	combination					1326:1336	the combination	1322:1336	the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs)	1322:1418	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	4	21	theme	soy	760:762	arg1	content					786:792	soy protein isolate (SPI) content	760:792	soy protein isolate (SPI) content	760:792	The results indicated that HCSS exhibited an interconnected porous microstructure and a high water retention ratio with the increase in soy protein isolate (SPI) content.
34375147	10	22	theme	nerve	1865:1869	arg1	repair					1871:1876	Impact statement Peripheral nerve repair	1837:1876	Impact statement Peripheral nerve repair	1837:1876	Impact statement Peripheral nerve repair is of paramount significance in the clinical.
34375147	5	23	theme	factors	965:971	arg1	secretion					938:946	the secretion	934:946	the secretion of neuro-related factors	934:971	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	5	23	theme	factors	965:971	arg1	proliferation					901:913	the proliferation	897:913	the proliferation of RSC96 cells	897:928	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	9	24	theme	alternative	1780:1790	arg1	HCSS-50					1732:1738	HCSS-50	1732:1738	HCSS-50	1732:1738	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	9	24	theme	alternative	1780:1790	arg1	SCs					1757:1759	BMSC-derived SCs	1744:1759	BMSC-derived SCs	1744:1759	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	9	24	theme	alternative	1780:1790	arg1	candidate					1792:1800	an alternative candidate	1777:1800	an alternative candidate for peripheral nerve regeneration	1777:1834	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	7	25	theme	BMSC-derived	1387:1398	arg1	SCs					1415:1417	SCs	1415:1417	SCs	1415:1417	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	7	25	theme	BMSC-derived	1387:1398	arg1	cells					1408:1412	BMSC-derived Schwann cells	1387:1412	BMSC-derived Schwann cells (SCs)	1387:1418	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	4	26	theme	isolate	772:778	arg1	content					786:792	soy protein isolate (SPI) content	760:792	soy protein isolate (SPI) content	760:792	The results indicated that HCSS exhibited an interconnected porous microstructure and a high water retention ratio with the increase in soy protein isolate (SPI) content.
34375147	5	27	theme	species	1007:1013	arg1	production					1015:1024	excessive reactive oxygen species production	981:1024	excessive reactive oxygen species production	981:1024	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	2	28	theme	hydroxypropyl	276:288	arg1	HCSS					338:341	HCSS	338:341	HCSS	338:341	Herein, a series of hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS) were fabricated by a freeze-drying technique.
34375147	2	28	theme	hydroxypropyl	276:288	arg1	sponges					329:335	hydroxypropyl chitosan/soy protein isolate composite sponges	276:335	hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS)	276:342	Herein, a series of hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS) were fabricated by a freeze-drying technique.
34375147	5	29	theme	excessive	981:989	arg1	production					1015:1024	excessive reactive oxygen species production	981:1024	excessive reactive oxygen species production	981:1024	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	7	30	theme	repair	1281:1286	arg1	injury					1302:1307	repair sciatic nerve injury	1281:1307	repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs)	1281:1418	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	5	31	theme	SPI	865:867	arg1	content					869:875	50% SPI content	861:875	50% SPI content	861:875	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	9	32	theme	nerve	1817:1821	arg1	regeneration					1823:1834	peripheral nerve regeneration	1806:1834	peripheral nerve regeneration	1806:1834	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	12	33	theme	nerve	2160:2164	arg1	regeneration					2166:2177	peripheral nerve regeneration	2149:2177	peripheral nerve regeneration	2149:2177	Thus, we provide a potential candidate for peripheral nerve regeneration.
34375147	1	34	theme	neuro-related	184:196	arg1	factors					198:204	neuro-related factors	184:204	neuro-related factors	184:204	Designing scaffolds, with optimized microstructure and function for promoting the release of neuro-related factors, is significant in peripheral nerve regeneration.
34375147	11	35	theme	neuro-related	2083:2095	arg1	factors					2097:2103	neuro-related factors	2083:2103	neuro-related factors	2083:2103	This work describes a hydroxypropyl chitosan/soy protein isolate conduit, which could effectively promote axonal regeneration and upregulate the expression of neuro-related factors.
34375147	3	36	theme	infrared	470:477	arg1	assay					562:566	water absorption assay	545:566	water absorption assay	545:566	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	36	theme	infrared	470:477	arg1	spectrometer					479:490	a Fourier infrared spectrometer	460:490	a Fourier infrared spectrometer	460:490	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	36	theme	infrared	470:477	arg1	assay					617:621	compressive strength assay	596:621	compressive strength assay	596:621	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	36	theme	infrared	470:477	arg1	microscope					533:542	scanning electron microscope	515:542	scanning electron microscope	515:542	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	36	theme	infrared	470:477	arg1	assay					585:589	water retention assay	569:589	water retention assay	569:589	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	36	theme	infrared	470:477	arg1	diffractometer					499:512	X-ray diffractometer	493:512	X-ray diffractometer	493:512	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	8	37	link	BMSC-derived	1496:1507	arg1	SCs					1509:1511	the constructed HCSS-based conduit accompanying BMSC-derived SCs	1448:1511	the constructed HCSS-based conduit accompanying BMSC-derived SCs	1448:1511	The results suggested that the constructed HCSS-based conduit accompanying BMSC-derived SCs could effectively promote axonal regeneration and upregulate the expression of neuro-related factors such as Krox20, Zeb2, and GAP43.
34375147	8	38	theme	neuro-related	1592:1604	arg1	Krox20					1622:1627	Krox20	1622:1627	Krox20	1622:1627	The results suggested that the constructed HCSS-based conduit accompanying BMSC-derived SCs could effectively promote axonal regeneration and upregulate the expression of neuro-related factors such as Krox20, Zeb2, and GAP43.
34375147	8	38	theme	neuro-related	1592:1604	arg1	GAP43					1640:1644	GAP43	1640:1644	GAP43	1640:1644	The results suggested that the constructed HCSS-based conduit accompanying BMSC-derived SCs could effectively promote axonal regeneration and upregulate the expression of neuro-related factors such as Krox20, Zeb2, and GAP43.
34375147	8	38	theme	neuro-related	1592:1604	arg1	Zeb2					1630:1633	Zeb2	1630:1633	Zeb2	1630:1633	The results suggested that the constructed HCSS-based conduit accompanying BMSC-derived SCs could effectively promote axonal regeneration and upregulate the expression of neuro-related factors such as Krox20, Zeb2, and GAP43.
34375147	8	38	theme	neuro-related	1592:1604	arg1	factors					1606:1612	neuro-related factors	1592:1612	neuro-related factors such as Krox20, Zeb2, and GAP43	1592:1644	The results suggested that the constructed HCSS-based conduit accompanying BMSC-derived SCs could effectively promote axonal regeneration and upregulate the expression of neuro-related factors such as Krox20, Zeb2, and GAP43.
34375147	4	39	theme	SPI	781:783	arg1	content					786:792	soy protein isolate (SPI) content	760:792	soy protein isolate (SPI) content	760:792	The results indicated that HCSS exhibited an interconnected porous microstructure and a high water retention ratio with the increase in soy protein isolate (SPI) content.
34375147	11	40	theme	protein	1973:1979	arg1	conduit					1989:1995	a hydroxypropyl chitosan/soy protein isolate conduit	1944:1995	a hydroxypropyl chitosan/soy protein isolate conduit	1944:1995	This work describes a hydroxypropyl chitosan/soy protein isolate conduit, which could effectively promote axonal regeneration and upregulate the expression of neuro-related factors.
34375147	0	41	theme	Hydroxypropyl	0:12	arg1	Conduits					43:50	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits	0:50	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits	0:50	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits Promote Peripheral Nerve Regeneration.
34375147	5	42	theme	oxygen	1000:1005	arg1	species					1007:1013	reactive oxygen species	991:1013	excessive reactive oxygen species production	981:1024	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	10	43	from	significance	1894:1905	arg1	clinical					1914:1921	clinical	1914:1921	clinical	1914:1921	Impact statement Peripheral nerve repair is of paramount significance in the clinical.
34375147	7	44	link	BMSC-derived	1387:1398	arg1	SCs					1415:1417	SCs	1415:1417	SCs	1415:1417	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	7	44	link	BMSC-derived	1387:1398	arg1	cells					1408:1412	BMSC-derived Schwann cells	1387:1412	BMSC-derived Schwann cells (SCs)	1387:1418	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	0	45	theme	Protein	27:33	arg1	Conduits					43:50	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits	0:50	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits	0:50	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits Promote Peripheral Nerve Regeneration.
34375147	2	46	theme	isolate	311:317	arg1	HCSS					338:341	HCSS	338:341	HCSS	338:341	Herein, a series of hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS) were fabricated by a freeze-drying technique.
34375147	2	46	theme	isolate	311:317	arg1	sponges					329:335	hydroxypropyl chitosan/soy protein isolate composite sponges	276:335	hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS)	276:342	Herein, a series of hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS) were fabricated by a freeze-drying technique.
34375147	7	47	theme	mesenchymal	1353:1363	arg1	cells					1370:1374	mesenchymal stem cells	1353:1374	mesenchymal stem cells (BMSCs)	1353:1382	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	7	47	theme	mesenchymal	1353:1363	arg1	BMSCs					1377:1381	BMSCs	1377:1381	BMSCs	1377:1381	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	7	48	theme	optimized	1221:1229	arg1	conduit					1242:1248	an optimized HCSS-based conduit	1218:1248	an optimized HCSS-based conduit	1218:1248	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	7	49	theme	bone	1341:1344	arg1	marrow					1346:1351	bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs)	1341:1418	marrow	1346:1351	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	3	50	theme	HCSS	438:441	arg1	properties					410:419	The physicochemical properties	390:419	The physicochemical properties of the resultant HCSS	390:441	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	2	51	theme	freeze-drying	365:377	arg1	technique					379:387	a freeze-drying technique	363:387	a freeze-drying technique	363:387	Herein, a series of hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS) were fabricated by a freeze-drying technique.
34375147	0	52	theme	Peripheral	60:69	arg1	Regeneration					77:88	Peripheral Nerve Regeneration	60:88	Peripheral Nerve Regeneration	60:88	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits Promote Peripheral Nerve Regeneration.
34375147	10	53	theme	paramount	1884:1892	arg1	significance					1894:1905	paramount significance	1884:1905	paramount significance	1884:1905	Impact statement Peripheral nerve repair is of paramount significance in the clinical.
34375147	3	54	theme	scanning	515:522	arg1	microscope					533:542	scanning electron microscope	515:542	scanning electron microscope	515:542	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	54	theme	scanning	515:522	arg1	spectrometer					479:490	a Fourier infrared spectrometer	460:490	a Fourier infrared spectrometer	460:490	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	55	theme	retention	575:583	arg1	assay					585:589	water retention assay	569:589	water retention assay	569:589	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	55	theme	retention	575:583	arg1	spectrometer					479:490	a Fourier infrared spectrometer	460:490	a Fourier infrared spectrometer	460:490	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	9	56	theme	engineered	1669:1678	arg1	system					1694:1699	a newly engineered nerve conduit system	1661:1699	a newly engineered nerve conduit system	1661:1699	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	6	57	theme	higher	1170:1175	arg1	times					1164:1168	three times	1158:1168	three times higher than that of the control group	1158:1206	In addition, HCSS-50 could significantly promote the expression of neuro-related factors; for example, the expression of TGF-β was three times higher than that of the control group.
34375147	6	57	theme	higher	1170:1175	arg1	expression					1134:1143	the expression	1130:1143	the expression of TGF-β	1130:1152	In addition, HCSS-50 could significantly promote the expression of neuro-related factors; for example, the expression of TGF-β was three times higher than that of the control group.
34375147	6	58	theme	factors	1108:1114	arg1	expression					1080:1089	the expression	1076:1089	the expression of neuro-related factors	1076:1114	In addition, HCSS-50 could significantly promote the expression of neuro-related factors; for example, the expression of TGF-β was three times higher than that of the control group.
34375147	8	59	theme	HCSS-based	1464:1473	arg1	SCs					1509:1511	the constructed HCSS-based conduit accompanying BMSC-derived SCs	1448:1511	the constructed HCSS-based conduit accompanying BMSC-derived SCs	1448:1511	The results suggested that the constructed HCSS-based conduit accompanying BMSC-derived SCs could effectively promote axonal regeneration and upregulate the expression of neuro-related factors such as Krox20, Zeb2, and GAP43.
34375147	11	60	theme	hydroxypropyl	1946:1958	arg1	conduit					1989:1995	a hydroxypropyl chitosan/soy protein isolate conduit	1944:1995	a hydroxypropyl chitosan/soy protein isolate conduit	1944:1995	This work describes a hydroxypropyl chitosan/soy protein isolate conduit, which could effectively promote axonal regeneration and upregulate the expression of neuro-related factors.
34375147	9	61	theme	conduit	1686:1692	arg1	system					1694:1699	a newly engineered nerve conduit system	1661:1699	a newly engineered nerve conduit system	1661:1699	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	3	62	theme	water	545:549	arg1	absorption					551:560	water absorption	545:560	water absorption assay	545:566	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	7	63	theme	nerve	1296:1300	arg1	injury					1302:1307	repair sciatic nerve injury	1281:1307	repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs)	1281:1418	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	2	64	theme	sponges	329:335	arg1	series					266:271	a series	264:271	a series of hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS)	264:342	Herein, a series of hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS) were fabricated by a freeze-drying technique.
34375147	10	65	theme	Peripheral	1854:1863	arg1	repair					1871:1876	Impact statement Peripheral nerve repair	1837:1876	Impact statement Peripheral nerve repair	1837:1876	Impact statement Peripheral nerve repair is of paramount significance in the clinical.
34375147	7	66	from	injury	1302:1307	arg1	rats					1312:1315	rats	1312:1315	rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs)	1312:1418	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	7	67	with	rats	1312:1315	arg1	combination					1326:1336	the combination	1322:1336	the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs)	1322:1418	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	3	68	theme	water	569:573	arg1	assay					585:589	water retention assay	569:589	water retention assay	569:589	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	68	theme	water	569:573	arg1	spectrometer					479:490	a Fourier infrared spectrometer	460:490	a Fourier infrared spectrometer	460:490	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	1	69	theme	factors	198:204	arg1	release					173:179	the release	169:179	the release of neuro-related factors	169:204	Designing scaffolds, with optimized microstructure and function for promoting the release of neuro-related factors, is significant in peripheral nerve regeneration.
34375147	3	70	theme	strength	608:615	arg1	spectrometer					479:490	a Fourier infrared spectrometer	460:490	a Fourier infrared spectrometer	460:490	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	70	theme	strength	608:615	arg1	assay					617:621	compressive strength assay	596:621	compressive strength assay	596:621	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	5	71	theme	RSC96	918:922	arg1	cells					924:928	RSC96 cells	918:928	RSC96 cells	918:928	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	9	72	theme	BMSC-derived	1744:1755	arg1	HCSS-50					1732:1738	HCSS-50	1732:1738	HCSS-50	1732:1738	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	9	72	theme	BMSC-derived	1744:1755	arg1	SCs					1757:1759	BMSC-derived SCs	1744:1759	BMSC-derived SCs	1744:1759	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	9	72	theme	BMSC-derived	1744:1755	arg1	candidate					1792:1800	an alternative candidate	1777:1800	an alternative candidate for peripheral nerve regeneration	1777:1834	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	4	73	theme	water	717:721	arg1	ratio					733:737	a high water retention ratio	710:737	a high water retention ratio	710:737	The results indicated that HCSS exhibited an interconnected porous microstructure and a high water retention ratio with the increase in soy protein isolate (SPI) content.
34375147	10	74	theme	Impact	1837:1842	arg1	repair					1871:1876	Impact statement Peripheral nerve repair	1837:1876	Impact statement Peripheral nerve repair	1837:1876	Impact statement Peripheral nerve repair is of paramount significance in the clinical.
34375147	8	75	theme	accompanying	1483:1494	arg1	SCs					1509:1511	the constructed HCSS-based conduit accompanying BMSC-derived SCs	1448:1511	the constructed HCSS-based conduit accompanying BMSC-derived SCs	1448:1511	The results suggested that the constructed HCSS-based conduit accompanying BMSC-derived SCs could effectively promote axonal regeneration and upregulate the expression of neuro-related factors such as Krox20, Zeb2, and GAP43.
34375147	4	76	theme	interconnected	669:682	arg1	microstructure					691:704	an interconnected porous microstructure	666:704	an interconnected porous microstructure	666:704	The results indicated that HCSS exhibited an interconnected porous microstructure and a high water retention ratio with the increase in soy protein isolate (SPI) content.
34375147	1	77	theme	nerve	236:240	arg1	regeneration					242:253	peripheral nerve regeneration	225:253	peripheral nerve regeneration	225:253	Designing scaffolds, with optimized microstructure and function for promoting the release of neuro-related factors, is significant in peripheral nerve regeneration.
34375147	1	78	with	scaffolds	101:109	arg1	function					146:153	function	146:153	function	146:153	Designing scaffolds, with optimized microstructure and function for promoting the release of neuro-related factors, is significant in peripheral nerve regeneration.
34375147	1	78	with	scaffolds	101:109	arg1	microstructure					127:140	microstructure	127:140	microstructure	127:140	Designing scaffolds, with optimized microstructure and function for promoting the release of neuro-related factors, is significant in peripheral nerve regeneration.
34375147	11	79	theme	factors	2097:2103	arg1	expression					2069:2078	the expression	2065:2078	the expression of neuro-related factors	2065:2103	This work describes a hydroxypropyl chitosan/soy protein isolate conduit, which could effectively promote axonal regeneration and upregulate the expression of neuro-related factors.
34375147	11	80	theme	axonal	2030:2035	arg1	regeneration					2037:2048	axonal regeneration	2030:2048	axonal regeneration	2030:2048	This work describes a hydroxypropyl chitosan/soy protein isolate conduit, which could effectively promote axonal regeneration and upregulate the expression of neuro-related factors.
34375147	1	81	from	regeneration	242:253	arg1	significant					210:220	significant	210:220	significant	210:220	Designing scaffolds, with optimized microstructure and function for promoting the release of neuro-related factors, is significant in peripheral nerve regeneration.
34375147	5	82	theme	neuro-related	951:963	arg1	factors					965:971	neuro-related factors	951:971	neuro-related factors	951:971	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	2	83	theme	chitosan/soy	290:301	arg1	HCSS					338:341	HCSS	338:341	HCSS	338:341	Herein, a series of hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS) were fabricated by a freeze-drying technique.
34375147	2	83	theme	chitosan/soy	290:301	arg1	sponges					329:335	hydroxypropyl chitosan/soy protein isolate composite sponges	276:335	hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS)	276:342	Herein, a series of hydroxypropyl chitosan/soy protein isolate composite sponges (HCSS) were fabricated by a freeze-drying technique.
34375147	6	84	theme	neuro-related	1094:1106	arg1	factors					1108:1114	neuro-related factors	1094:1114	neuro-related factors	1094:1114	In addition, HCSS-50 could significantly promote the expression of neuro-related factors; for example, the expression of TGF-β was three times higher than that of the control group.
34375147	8	85	theme	axonal	1539:1544	arg1	regeneration					1546:1557	axonal regeneration	1539:1557	axonal regeneration	1539:1557	The results suggested that the constructed HCSS-based conduit accompanying BMSC-derived SCs could effectively promote axonal regeneration and upregulate the expression of neuro-related factors such as Krox20, Zeb2, and GAP43.
34375147	7	86	theme	Schwann	1400:1406	arg1	SCs					1415:1417	SCs	1415:1417	SCs	1415:1417	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	7	86	theme	Schwann	1400:1406	arg1	cells					1408:1412	BMSC-derived Schwann cells	1387:1412	BMSC-derived Schwann cells (SCs)	1387:1418	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	4	87	theme	protein	764:770	arg1	content					786:792	soy protein isolate (SPI) content	760:792	soy protein isolate (SPI) content	760:792	The results indicated that HCSS exhibited an interconnected porous microstructure and a high water retention ratio with the increase in soy protein isolate (SPI) content.
34375147	1	88	from	significant	210:220	arg1	regeneration					242:253	peripheral nerve regeneration	225:253	peripheral nerve regeneration	225:253	Designing scaffolds, with optimized microstructure and function for promoting the release of neuro-related factors, is significant in peripheral nerve regeneration.
34375147	9	89	theme	peripheral	1806:1815	arg1	regeneration					1823:1834	peripheral nerve regeneration	1806:1834	peripheral nerve regeneration	1806:1834	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	5	90	theme	biological	799:808	arg1	characterization					810:825	The biological characterization	795:825	The biological characterization	795:825	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	12	91	theme	peripheral	2149:2158	arg1	regeneration					2166:2177	peripheral nerve regeneration	2149:2177	peripheral nerve regeneration	2149:2177	Thus, we provide a potential candidate for peripheral nerve regeneration.
34375147	3	92	theme	physicochemical	394:408	arg1	properties					410:419	The physicochemical properties	390:419	The physicochemical properties of the resultant HCSS	390:441	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	7	93	theme	HCSS-based	1231:1240	arg1	conduit					1242:1248	an optimized HCSS-based conduit	1218:1248	an optimized HCSS-based conduit	1218:1248	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	1	94	theme	Designing	91:99	arg1	scaffolds					101:109	Designing scaffolds	91:109	Designing scaffolds	91:109	Designing scaffolds, with optimized microstructure and function for promoting the release of neuro-related factors, is significant in peripheral nerve regeneration.
34375147	8	95	theme	factors	1606:1612	arg1	expression					1578:1587	the expression	1574:1587	the expression of neuro-related factors such as Krox20, Zeb2, and GAP43	1574:1644	The results suggested that the constructed HCSS-based conduit accompanying BMSC-derived SCs could effectively promote axonal regeneration and upregulate the expression of neuro-related factors such as Krox20, Zeb2, and GAP43.
34375147	0	96	theme	Chitosan/Soy	14:25	arg1	Conduits					43:50	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits	0:50	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits	0:50	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits Promote Peripheral Nerve Regeneration.
34375147	5	97	theme	reactive	991:998	arg1	species					1007:1013	reactive oxygen species	991:1013	excessive reactive oxygen species production	981:1024	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	7	98	theme	stem	1365:1368	arg1	cells					1370:1374	mesenchymal stem cells	1353:1374	mesenchymal stem cells (BMSCs)	1353:1382	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	7	98	theme	stem	1365:1368	arg1	BMSCs					1377:1381	BMSCs	1377:1381	BMSCs	1377:1381	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	3	99	theme	resultant	428:436	arg1	HCSS					438:441	the resultant HCSS	424:441	the resultant HCSS	424:441	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	100	theme	Fourier	462:468	arg1	assay					562:566	water absorption assay	545:566	water absorption assay	545:566	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	100	theme	Fourier	462:468	arg1	spectrometer					479:490	a Fourier infrared spectrometer	460:490	a Fourier infrared spectrometer	460:490	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	100	theme	Fourier	462:468	arg1	assay					617:621	compressive strength assay	596:621	compressive strength assay	596:621	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	100	theme	Fourier	462:468	arg1	microscope					533:542	scanning electron microscope	515:542	scanning electron microscope	515:542	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	100	theme	Fourier	462:468	arg1	assay					585:589	water retention assay	569:589	water retention assay	569:589	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	100	theme	Fourier	462:468	arg1	diffractometer					499:512	X-ray diffractometer	493:512	X-ray diffractometer	493:512	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	0	101	theme	Isolate	35:41	arg1	Conduits					43:50	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits	0:50	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits	0:50	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits Promote Peripheral Nerve Regeneration.
34375147	5	102	theme	50	861:862	arg1	%					863:863	%	863:863	%	863:863	The biological characterization found that the HCSS-50 containing 50% SPI content profoundly promoted the proliferation of RSC96 cells and the secretion of neuro-related factors without excessive reactive oxygen species production.
34375147	1	103	theme	optimized	117:125	arg1	microstructure					127:140	microstructure	127:140	microstructure	127:140	Designing scaffolds, with optimized microstructure and function for promoting the release of neuro-related factors, is significant in peripheral nerve regeneration.
34375147	7	104	theme	marrow	1346:1351	arg1	combination					1326:1336	the combination	1322:1336	the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs)	1322:1418	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	3	105	theme	X-ray	493:497	arg1	spectrometer					479:490	a Fourier infrared spectrometer	460:490	a Fourier infrared spectrometer	460:490	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	105	theme	X-ray	493:497	arg1	diffractometer					499:512	X-ray diffractometer	493:512	X-ray diffractometer	493:512	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	0	106	theme	Nerve	71:75	arg1	Regeneration					77:88	Peripheral Nerve Regeneration	60:88	Peripheral Nerve Regeneration	60:88	Hydroxypropyl Chitosan/Soy Protein Isolate Conduits Promote Peripheral Nerve Regeneration.
34375147	3	107	theme	electron	524:531	arg1	microscope					533:542	scanning electron microscope	515:542	scanning electron microscope	515:542	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	3	107	theme	electron	524:531	arg1	spectrometer					479:490	a Fourier infrared spectrometer	460:490	a Fourier infrared spectrometer	460:490	The physicochemical properties of the resultant HCSS were examined by a Fourier infrared spectrometer, X-ray diffractometer, scanning electron microscope, water absorption assay, water retention assay, and compressive strength assay.
34375147	7	108	dep	marrow	1346:1351	arg1	cells					1370:1374	mesenchymal stem cells	1353:1374	mesenchymal stem cells (BMSCs)	1353:1382	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	7	108	dep	marrow	1346:1351	arg1	BMSCs					1377:1381	BMSCs	1377:1381	BMSCs	1377:1381	Finally, an optimized HCSS-based conduit was fabricated from HCSS-50 to repair sciatic nerve injury in rats with the combination of bone marrow mesenchymal stem cells (BMSCs) or BMSC-derived Schwann cells (SCs).
34375147	9	109	link	BMSC-derived	1744:1755	arg1	HCSS-50					1732:1738	HCSS-50	1732:1738	HCSS-50	1732:1738	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	9	109	link	BMSC-derived	1744:1755	arg1	SCs					1757:1759	BMSC-derived SCs	1744:1759	BMSC-derived SCs	1744:1759	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	9	109	link	BMSC-derived	1744:1755	arg1	candidate					1792:1800	an alternative candidate	1777:1800	an alternative candidate for peripheral nerve regeneration	1777:1834	Collectively, a newly engineered nerve conduit system was developed by incorporating HCSS-50 and BMSC-derived SCs, which could be an alternative candidate for peripheral nerve regeneration.
34375147	8	110	theme	constructed	1452:1462	arg1	SCs					1509:1511	the constructed HCSS-based conduit accompanying BMSC-derived SCs	1448:1511	the constructed HCSS-based conduit accompanying BMSC-derived SCs	1448:1511	The results suggested that the constructed HCSS-based conduit accompanying BMSC-derived SCs could effectively promote axonal regeneration and upregulate the expression of neuro-related factors such as Krox20, Zeb2, and GAP43.
34375147	11	111	theme	chitosan/soy	1960:1971	arg1	conduit					1989:1995	a hydroxypropyl chitosan/soy protein isolate conduit	1944:1995	a hydroxypropyl chitosan/soy protein isolate conduit	1944:1995	This work describes a hydroxypropyl chitosan/soy protein isolate conduit, which could effectively promote axonal regeneration and upregulate the expression of neuro-related factors.
34375147	4	112	from	increase	748:755	arg1	content					786:792	soy protein isolate (SPI) content	760:792	soy protein isolate (SPI) content	760:792	The results indicated that HCSS exhibited an interconnected porous microstructure and a high water retention ratio with the increase in soy protein isolate (SPI) content.
33804535	0	0	theme	Bast	77:80	arg1	Fibres					82:87	the Early Middle Ages Hemp Bast Fibres	50:87	the Early Middle Ages Hemp Bast Fibres	50:87	Vibrational Spectroscopic Analyses and Imaging of the Early Middle Ages Hemp Bast Fibres Recovered from Lake Sediments.
33804535	2	1	theme	process	467:473	arg1	process					467:473	the hemp retting process	450:473	the hemp retting process	450:473	The examined plant macrofossil material constitutes residues of the hemp retting process that took place in the 7th-8th century.
33804535	2	1	theme	process	467:473	arg1	residues					438:445	residues	438:445	residues of the hemp retting process that took place in the 7th-8th century	438:512	The examined plant macrofossil material constitutes residues of the hemp retting process that took place in the 7th-8th century.
33804535	3	2	theme	retting	652:658	arg1	conditions					660:669	the retting conditions	648:669	the retting conditions	648:669	By comparison of three samples: untreated isolated bast fibres, and fibres incubated overnight at 4 and 37 °C, we were able to mimic the retting conditions.
33804535	1	3	theme	FT-IR	148:152	arg1	spectroscopy					155:166	Infrared (FT-IR) spectroscopy	138:166	Infrared (FT-IR) spectroscopy	138:166	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	7	4	theme	fibres	1416:1421	arg1	composition					1395:1405	biochemical composition	1383:1405	biochemical composition of plant fibres without preparation	1383:1441	In this study, we show that the spectroscopic methods allow for a non-destructive evaluation of biochemical composition of plant fibres without preparation, which can be an appropriate approach for studying ancient plant remains.
33804535	0	5	theme	Hemp	72:75	arg1	Fibres					82:87	the Early Middle Ages Hemp Bast Fibres	50:87	the Early Middle Ages Hemp Bast Fibres	50:87	Vibrational Spectroscopic Analyses and Imaging of the Early Middle Ages Hemp Bast Fibres Recovered from Lake Sediments.
33804535	7	6	theme	ancient	1494:1500	arg1	plant					1502:1506	ancient plant remains	1494:1514	ancient plant remains	1494:1514	In this study, we show that the spectroscopic methods allow for a non-destructive evaluation of biochemical composition of plant fibres without preparation, which can be an appropriate approach for studying ancient plant remains.
33804535	2	7	theme	7th-8th	498:504	arg1	century					506:512	the 7th-8th century	494:512	the 7th-8th century	494:512	The examined plant macrofossil material constitutes residues of the hemp retting process that took place in the 7th-8th century.
33804535	1	8	theme	bast	323:326	arg1	fibres					328:333	Early Middle Ages hemp (Cannabis sativa L.) bast fibres	279:333	Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone	279:383	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	6	9	theme	higher	1176:1181	arg1	content					1189:1195	a higher amide content	1174:1195	a higher amide content	1174:1195	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	1	10	dep	Fourier	120:126	arg1	Transform					128:136	Transform	128:136	Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA)	128:228	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	5	11	theme	pectin	957:962	arg1	concentration					929:941	the concentration	925:941	the concentration of lignin and pectin	925:962	The concentration of cellulose remained vastly unchanged, while the concentration of lignin and pectin was the highest in the untreated sample.
33804535	5	11	theme	pectin	957:962	arg1	highest					972:978	highest	972:978	highest	972:978	The concentration of cellulose remained vastly unchanged, while the concentration of lignin and pectin was the highest in the untreated sample.
33804535	0	12	theme	Fibres	82:87	arg1	Analyses					26:33	Vibrational Spectroscopic Analyses	0:33	Vibrational Spectroscopic Analyses	0:33	Vibrational Spectroscopic Analyses and Imaging of the Early Middle Ages Hemp Bast Fibres Recovered from Lake Sediments.
33804535	0	12	theme	Fibres	82:87	arg1	Imaging					39:45	Imaging	39:45	Imaging of the Early Middle Ages Hemp Bast Fibres	39:87	Vibrational Spectroscopic Analyses and Imaging of the Early Middle Ages Hemp Bast Fibres Recovered from Lake Sediments.
33804535	1	13	theme	fibres	328:333	arg1	properties					265:274	biochemical properties	253:274	biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone	253:383	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	6	14	theme	latter	1217:1222	arg1	sample					1224:1229	the latter sample	1213:1229	the latter sample	1213:1229	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	4	15	theme	semi-quantitative	700:716	arg1	assessment					718:727	FT-IR qualitative and semi-quantitative assessment	678:727	FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides	678:758	Using FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides content, total protein content, and their spatial distribution was performed within the hemp fibres.
33804535	6	16	from	specimen	1130:1137	arg1	heterogeneous					1049:1061	heterogeneous	1049:1061	heterogeneous	1049:1061	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	6	16	from	specimen	1130:1137	arg1	distributions					1017:1029	The spatial distributions	1005:1029	The spatial distributions of compounds	1005:1042	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	1	17	theme	biochemical	253:263	arg1	properties					265:274	biochemical properties	253:274	biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone	253:383	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	0	18	theme	Lake	104:107	arg1	Sediments					109:117	Lake Sediments	104:117	Lake Sediments	104:117	Vibrational Spectroscopic Analyses and Imaging of the Early Middle Ages Hemp Bast Fibres Recovered from Lake Sediments.
33804535	1	19	dep	Cannabis	303:310	arg1	L.					319:320	Cannabis sativa L.	303:320	Cannabis sativa L.	303:320	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	4	20	theme	FT-IR	678:682	arg1	assessment					718:727	FT-IR qualitative and semi-quantitative assessment	678:727	FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides	678:758	Using FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides content, total protein content, and their spatial distribution was performed within the hemp fibres.
33804535	2	21	theme	retting	459:465	arg1	process					467:473	the hemp retting process	450:473	the hemp retting process	450:473	The examined plant macrofossil material constitutes residues of the hemp retting process that took place in the 7th-8th century.
33804535	5	22	theme	lignin	946:951	arg1	concentration					929:941	the concentration	925:941	the concentration of lignin and pectin	925:962	The concentration of cellulose remained vastly unchanged, while the concentration of lignin and pectin was the highest in the untreated sample.
33804535	5	22	theme	lignin	946:951	arg1	highest					972:978	highest	972:978	highest	972:978	The concentration of cellulose remained vastly unchanged, while the concentration of lignin and pectin was the highest in the untreated sample.
33804535	7	23	theme	plant	1410:1414	arg1	fibres					1416:1421	plant fibres	1410:1421	plant fibres	1410:1421	In this study, we show that the spectroscopic methods allow for a non-destructive evaluation of biochemical composition of plant fibres without preparation, which can be an appropriate approach for studying ancient plant remains.
33804535	6	24	theme	compounds	1034:1042	arg1	heterogeneous					1049:1061	heterogeneous	1049:1061	heterogeneous	1049:1061	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	6	24	theme	compounds	1034:1042	arg1	distributions					1017:1029	The spatial distributions	1005:1029	The spatial distributions of compounds	1005:1042	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	0	25	theme	Spectroscopic	12:24	arg1	Analyses					26:33	Vibrational Spectroscopic Analyses	0:33	Vibrational Spectroscopic Analyses	0:33	Vibrational Spectroscopic Analyses and Imaging of the Early Middle Ages Hemp Bast Fibres Recovered from Lake Sediments.
33804535	1	26	theme	lake	350:353	arg1	sediment					362:369	lake bottom sediment	350:369	lake bottom sediment of lake Słone	350:383	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	3	27	theme	samples	538:544	arg1	comparison					518:527	comparison	518:527	comparison of three samples: untreated isolated bast fibres, and fibres incubated overnight at 4 and 37 °C	518:623	By comparison of three samples: untreated isolated bast fibres, and fibres incubated overnight at 4 and 37 °C, we were able to mimic the retting conditions.
33804535	6	28	located	detected	1201:1208	arg2	content					1189:1195	a higher amide content	1174:1195	a higher amide content	1174:1195	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	6	28	located	detected	1201:1208	arg1	sample					1224:1229	the latter sample	1213:1229	the latter sample	1213:1229	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	7	29	theme	appropriate	1460:1470	arg1	approach					1472:1479	an appropriate approach	1457:1479	an appropriate approach for studying ancient plant remains	1457:1514	In this study, we show that the spectroscopic methods allow for a non-destructive evaluation of biochemical composition of plant fibres without preparation, which can be an appropriate approach for studying ancient plant remains.
33804535	7	29	theme	appropriate	1460:1470	arg1	which					1444:1448	which	1444:1448	which	1444:1448	In this study, we show that the spectroscopic methods allow for a non-destructive evaluation of biochemical composition of plant fibres without preparation, which can be an appropriate approach for studying ancient plant remains.
33804535	0	30	theme	Vibrational	0:10	arg1	Analyses					26:33	Vibrational Spectroscopic Analyses	0:33	Vibrational Spectroscopic Analyses	0:33	Vibrational Spectroscopic Analyses and Imaging of the Early Middle Ages Hemp Bast Fibres Recovered from Lake Sediments.
33804535	7	31	theme	biochemical	1383:1393	arg1	composition					1395:1405	biochemical composition	1383:1405	biochemical composition of plant fibres without preparation	1383:1441	In this study, we show that the spectroscopic methods allow for a non-destructive evaluation of biochemical composition of plant fibres without preparation, which can be an appropriate approach for studying ancient plant remains.
33804535	4	32	theme	spatial	802:808	arg1	distribution					810:821	their spatial distribution	796:821	their spatial distribution	796:821	Using FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides content, total protein content, and their spatial distribution was performed within the hemp fibres.
33804535	7	33	theme	non-destructive	1353:1367	arg1	evaluation					1369:1378	a non-destructive evaluation	1351:1378	a non-destructive evaluation of biochemical composition of plant fibres without preparation	1351:1441	In this study, we show that the spectroscopic methods allow for a non-destructive evaluation of biochemical composition of plant fibres without preparation, which can be an appropriate approach for studying ancient plant remains.
33804535	2	34	theme	macrofossil	405:415	arg1	material					417:424	The examined plant macrofossil material	386:424	The examined plant macrofossil material	386:424	The examined plant macrofossil material constitutes residues of the hemp retting process that took place in the 7th-8th century.
33804535	5	35	theme	untreated	987:995	arg1	sample					997:1002	the untreated sample	983:1002	the untreated sample	983:1002	The concentration of cellulose remained vastly unchanged, while the concentration of lignin and pectin was the highest in the untreated sample.
33804535	4	36	theme	protein	775:781	arg1	content					783:789	total protein content	769:789	total protein content	769:789	Using FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides content, total protein content, and their spatial distribution was performed within the hemp fibres.
33804535	2	37	theme	examined	390:397	arg1	material					417:424	The examined plant macrofossil material	386:424	The examined plant macrofossil material	386:424	The examined plant macrofossil material constitutes residues of the hemp retting process that took place in the 7th-8th century.
33804535	2	38	theme	plant	399:403	arg1	material					417:424	The examined plant macrofossil material	386:424	The examined plant macrofossil material	386:424	The examined plant macrofossil material constitutes residues of the hemp retting process that took place in the 7th-8th century.
33804535	1	39	theme	Early	279:283	arg1	fibres					328:333	Early Middle Ages hemp (Cannabis sativa L.) bast fibres	279:333	Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone	279:383	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	1	40	theme	bottom	355:360	arg1	sediment					362:369	lake bottom sediment	350:369	lake bottom sediment of lake Słone	350:383	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	4	41	theme	qualitative	684:694	arg1	assessment					718:727	FT-IR qualitative and semi-quantitative assessment	678:727	FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides	678:758	Using FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides content, total protein content, and their spatial distribution was performed within the hemp fibres.
33804535	1	42	theme	hierarchical	194:205	arg1	HCA					225:227	HCA	225:227	HCA	225:227	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	1	42	theme	hierarchical	194:205	arg1	analysis					215:222	hierarchical cluster analysis	194:222	hierarchical cluster analysis (HCA)	194:228	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	2	43	theme	hemp	454:457	arg1	process					467:473	the hemp retting process	450:473	the hemp retting process	450:473	The examined plant macrofossil material constitutes residues of the hemp retting process that took place in the 7th-8th century.
33804535	1	44	theme	Middle	285:290	arg1	hemp					297:300	Middle Ages hemp	285:300	Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone	279:383	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	1	44	theme	Middle	285:290	arg1	Cannabis					303:310	Cannabis sativa L.	303:320	Cannabis sativa L.	303:320	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	3	45	theme	bast	566:569	arg1	fibres					571:576	untreated isolated bast fibres	547:576	untreated isolated bast fibres	547:576	By comparison of three samples: untreated isolated bast fibres, and fibres incubated overnight at 4 and 37 °C, we were able to mimic the retting conditions.
33804535	1	46	theme	cluster	207:213	arg1	HCA					225:227	HCA	225:227	HCA	225:227	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	1	46	theme	cluster	207:213	arg1	analysis					215:222	hierarchical cluster analysis	194:222	hierarchical cluster analysis (HCA)	194:228	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	1	47	theme	Ages	292:295	arg1	hemp					297:300	Middle Ages hemp	285:300	Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone	279:383	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	1	47	theme	Ages	292:295	arg1	Cannabis					303:310	Cannabis sativa L.	303:320	Cannabis sativa L.	303:320	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	6	48	theme	degradation	1274:1284	arg1	degree					1254:1259	the highest degree	1242:1259	the highest degree of enzymatic degradation	1242:1284	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	3	49	theme	fibres	571:576	arg1	comparison					518:527	comparison	518:527	comparison of three samples: untreated isolated bast fibres, and fibres incubated overnight at 4 and 37 °C	518:623	By comparison of three samples: untreated isolated bast fibres, and fibres incubated overnight at 4 and 37 °C, we were able to mimic the retting conditions.
33804535	0	50	theme	Early	54:58	arg1	Fibres					82:87	the Early Middle Ages Hemp Bast Fibres	50:87	the Early Middle Ages Hemp Bast Fibres	50:87	Vibrational Spectroscopic Analyses and Imaging of the Early Middle Ages Hemp Bast Fibres Recovered from Lake Sediments.
33804535	1	51	theme	hemp	297:300	arg1	fibres					328:333	Early Middle Ages hemp (Cannabis sativa L.) bast fibres	279:333	Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone	279:383	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	6	52	theme	enzymatic	1264:1272	arg1	degradation					1274:1284	enzymatic degradation	1264:1284	enzymatic degradation	1264:1284	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	1	53	theme	lake	374:377	arg1	Słone					379:383	lake Słone	374:383	lake Słone	374:383	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	3	54	theme	untreated	547:555	arg1	fibres					571:576	untreated isolated bast fibres	547:576	untreated isolated bast fibres	547:576	By comparison of three samples: untreated isolated bast fibres, and fibres incubated overnight at 4 and 37 °C, we were able to mimic the retting conditions.
33804535	6	55	theme	untreated	1070:1078	arg1	samples					1099:1105	the untreated and 4 °C-incubated samples	1066:1105	the untreated and 4 °C-incubated samples	1066:1105	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	6	56	theme	amide	1183:1187	arg1	content					1189:1195	a higher amide content	1174:1195	a higher amide content	1174:1195	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	4	57	theme	hemp	848:851	arg1	fibres					853:858	the hemp fibres	844:858	the hemp fibres	844:858	Using FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides content, total protein content, and their spatial distribution was performed within the hemp fibres.
33804535	1	58	theme	Słone	379:383	arg1	sediment					362:369	lake bottom sediment	350:369	lake bottom sediment of lake Słone	350:383	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	3	59	theme	isolated	557:564	arg1	fibres					571:576	untreated isolated bast fibres	547:576	untreated isolated bast fibres	547:576	By comparison of three samples: untreated isolated bast fibres, and fibres incubated overnight at 4 and 37 °C, we were able to mimic the retting conditions.
33804535	6	60	from	samples	1099:1105	arg1	heterogeneous					1049:1061	heterogeneous	1049:1061	heterogeneous	1049:1061	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	6	60	from	samples	1099:1105	arg1	distributions					1017:1029	The spatial distributions	1005:1029	The spatial distributions of compounds	1005:1042	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	6	61	theme	°C-incubated	1086:1097	arg1	samples					1099:1105	the untreated and 4 °C-incubated samples	1066:1105	the untreated and 4 °C-incubated samples	1066:1105	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	4	62	theme	polysaccharides	744:758	arg1	assessment					718:727	FT-IR qualitative and semi-quantitative assessment	678:727	FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides	678:758	Using FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides content, total protein content, and their spatial distribution was performed within the hemp fibres.
33804535	3	63	theme	fibres	583:588	arg1	comparison					518:527	comparison	518:527	comparison of three samples: untreated isolated bast fibres, and fibres incubated overnight at 4 and 37 °C	518:623	By comparison of three samples: untreated isolated bast fibres, and fibres incubated overnight at 4 and 37 °C, we were able to mimic the retting conditions.
33804535	4	64	theme	total	769:773	arg1	content					783:789	total protein content	769:789	total protein content	769:789	Using FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides content, total protein content, and their spatial distribution was performed within the hemp fibres.
33804535	5	65	theme	cellulose	882:890	arg1	concentration					865:877	The concentration	861:877	The concentration of cellulose	861:890	The concentration of cellulose remained vastly unchanged, while the concentration of lignin and pectin was the highest in the untreated sample.
33804535	6	66	theme	highest	1246:1252	arg1	degree					1254:1259	the highest degree	1242:1259	the highest degree of enzymatic degradation	1242:1284	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	4	67	theme	primary	736:742	arg1	polysaccharides					744:758	the primary polysaccharides	732:758	the primary polysaccharides	732:758	Using FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides content, total protein content, and their spatial distribution was performed within the hemp fibres.
33804535	7	68	theme	spectroscopic	1319:1331	arg1	methods					1333:1339	the spectroscopic methods	1315:1339	the spectroscopic methods	1315:1339	In this study, we show that the spectroscopic methods allow for a non-destructive evaluation of biochemical composition of plant fibres without preparation, which can be an appropriate approach for studying ancient plant remains.
33804535	0	69	theme	Ages	67:70	arg1	Fibres					82:87	the Early Middle Ages Hemp Bast Fibres	50:87	the Early Middle Ages Hemp Bast Fibres	50:87	Vibrational Spectroscopic Analyses and Imaging of the Early Middle Ages Hemp Bast Fibres Recovered from Lake Sediments.
33804535	7	70	theme	composition	1395:1405	arg1	evaluation					1369:1378	a non-destructive evaluation	1351:1378	a non-destructive evaluation of biochemical composition of plant fibres without preparation	1351:1441	In this study, we show that the spectroscopic methods allow for a non-destructive evaluation of biochemical composition of plant fibres without preparation, which can be an appropriate approach for studying ancient plant remains.
33804535	6	71	theme	spatial	1009:1015	arg1	heterogeneous					1049:1061	heterogeneous	1049:1061	heterogeneous	1049:1061	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	6	71	theme	spatial	1009:1015	arg1	distributions					1017:1029	The spatial distributions	1005:1029	The spatial distributions of compounds	1005:1042	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	1	72	theme	Infrared	138:145	arg1	spectroscopy					155:166	Infrared (FT-IR) spectroscopy	138:166	Infrared (FT-IR) spectroscopy	138:166	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	0	73	theme	Middle	60:65	arg1	Fibres					82:87	the Early Middle Ages Hemp Bast Fibres	50:87	the Early Middle Ages Hemp Bast Fibres	50:87	Vibrational Spectroscopic Analyses and Imaging of the Early Middle Ages Hemp Bast Fibres Recovered from Lake Sediments.
33804535	1	74	theme	sativa	312:317	arg1	hemp					297:300	Middle Ages hemp	285:300	Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone	279:383	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	1	74	theme	sativa	312:317	arg1	Cannabis					303:310	Cannabis sativa L.	303:320	Cannabis sativa L.	303:320	Fourier Transform Infrared (FT-IR) spectroscopy and imaging combined with hierarchical cluster analysis (HCA) was applied to analyse biochemical properties of Early Middle Ages hemp (Cannabis sativa L.) bast fibres collected from lake bottom sediment of lake Słone.
33804535	4	75	dep	performed	827:835	arg1	Using					672:676	Using	672:676	Using FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides	672:758	Using FT-IR qualitative and semi-quantitative assessment of the primary polysaccharides content, total protein content, and their spatial distribution was performed within the hemp fibres.
33804535	6	76	from	heterogeneous	1049:1061	arg1	specimen					1130:1137	the specimen	1126:1137	the specimen processed at 37 °C.	1126:1157	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	6	76	from	heterogeneous	1049:1061	arg1	samples					1099:1105	the untreated and 4 °C-incubated samples	1066:1105	the untreated and 4 °C-incubated samples	1066:1105	The spatial distributions of compounds were heterogeneous in the untreated and 4 °C-incubated samples, and homogenous in the specimen processed at 37 °C. Interestingly, a higher amide content was detected in the latter sample indicating the highest degree of enzymatic degradation.
33804535	7	77	dep	plant	1502:1506	arg1	remains					1508:1514	remains	1508:1514	remains	1508:1514	In this study, we show that the spectroscopic methods allow for a non-destructive evaluation of biochemical composition of plant fibres without preparation, which can be an appropriate approach for studying ancient plant remains.
32057852	1	0	theme	biocompatible	178:190	arg1	carriers					197:204	efficient straightforward biocompatible drug carriers	152:204	efficient straightforward biocompatible drug carriers	152:204	Today, efficient straightforward biocompatible drug carriers have revoluted advanced drug delivery systems.
32057852	5	1	theme	intestinal	1038:1047	arg1	fluid					1049:1053	the simulated intestinal fluid	1024:1053	the simulated intestinal fluid	1024:1053	In-vitro studies showed that prepared bionanocomposites had a low release of PHT in the simulated gastric fluid while having a more controlled release in the simulated intestinal fluid.
32057852	1	2	theme	drug	192:195	arg1	carriers					197:204	efficient straightforward biocompatible drug carriers	152:204	efficient straightforward biocompatible drug carriers	152:204	Today, efficient straightforward biocompatible drug carriers have revoluted advanced drug delivery systems.
32057852	6	3	theme	drug	1182:1185	arg1	delivery					1187:1194	the controlled drug delivery	1167:1194	the controlled drug delivery of PHT	1167:1201	Because of the loading efficiency and controlled release profile, the composites exhibited great potential for the controlled drug delivery of PHT.
32057852	3	4	theme	UV	670:671	arg1	spectroscopy					673:684	UV spectroscopy	670:684	UV spectroscopy	670:684	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	3	5	theme	sodium	534:539	arg1	release					513:519	release	513:519	release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	513:693	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	5	6	theme	low	932:934	arg1	release					936:942	a low release	930:942	a low release of PHT in the simulated gastric fluid	930:980	In-vitro studies showed that prepared bionanocomposites had a low release of PHT in the simulated gastric fluid while having a more controlled release in the simulated intestinal fluid.
32057852	5	7	from	release	936:942	arg1	fluid					976:980	the simulated gastric fluid	954:980	the simulated gastric fluid	954:980	In-vitro studies showed that prepared bionanocomposites had a low release of PHT in the simulated gastric fluid while having a more controlled release in the simulated intestinal fluid.
32057852	4	8	contain	had	792:794	arg2	capacity					813:820	the best loading capacity	796:820	the best loading capacity (34.6 mg/g)	796:832	Based on the obtained results, HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2 had the best loading capacity (34.6 mg/g) compared with pure HNT (18.3 mg/g).
32057852	4	8	contain	had	792:794	arg1	nanocomposite					739:751	HNT/CTS/PCN nanocomposite	727:751	HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2	727:790	Based on the obtained results, HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2 had the best loading capacity (34.6 mg/g) compared with pure HNT (18.3 mg/g).
32057852	4	8	contain	had	792:794	arg2	34.6 mg/g					823:831	34.6 mg/g	823:831	34.6 mg/g	823:831	Based on the obtained results, HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2 had the best loading capacity (34.6 mg/g) compared with pure HNT (18.3 mg/g).
32057852	0	9	theme	controlled	105:114	arg1	release					116:122	controlled release	105:122	controlled release of phenytoin sodium	105:142	Three-ply biocompatible pH-responsive nanocarriers based on HNT sandwiched by chitosan/pectin layers for controlled release of phenytoin sodium.
32057852	4	10	theme	pure	848:851	arg1	18.3 mg/g					858:866	18.3 mg/g	858:866	18.3 mg/g	858:866	Based on the obtained results, HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2 had the best loading capacity (34.6 mg/g) compared with pure HNT (18.3 mg/g).
32057852	4	10	theme	pure	848:851	arg1	HNT					853:855	pure HNT	848:855	pure HNT (18.3 mg/g)	848:867	Based on the obtained results, HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2 had the best loading capacity (34.6 mg/g) compared with pure HNT (18.3 mg/g).
32057852	6	11	theme	controlled	1171:1180	arg1	delivery					1187:1194	the controlled drug delivery	1167:1194	the controlled drug delivery of PHT	1167:1201	Because of the loading efficiency and controlled release profile, the composites exhibited great potential for the controlled drug delivery of PHT.
32057852	6	12	theme	great	1147:1151	arg1	potential					1153:1161	great potential	1147:1161	great potential for the controlled drug delivery of PHT	1147:1201	Because of the loading efficiency and controlled release profile, the composites exhibited great potential for the controlled drug delivery of PHT.
32057852	6	13	theme	loading	1071:1077	arg1	efficiency					1079:1088	the loading efficiency	1067:1088	the loading efficiency	1067:1088	Because of the loading efficiency and controlled release profile, the composites exhibited great potential for the controlled drug delivery of PHT.
32057852	0	14	theme	phenytoin	127:135	arg1	sodium					137:142	phenytoin sodium	127:142	phenytoin sodium	127:142	Three-ply biocompatible pH-responsive nanocarriers based on HNT sandwiched by chitosan/pectin layers for controlled release of phenytoin sodium.
32057852	6	15	theme	controlled	1094:1103	arg1	profile					1113:1119	controlled release profile	1094:1119	controlled release profile	1094:1119	Because of the loading efficiency and controlled release profile, the composites exhibited great potential for the controlled drug delivery of PHT.
32057852	3	16	theme	loading	482:488	arg1	efficiency					490:499	loading efficiency	482:499	loading efficiency	482:499	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	2	17	theme	nanotubes	314:322	arg1	modification					287:298	the modification	283:298	the modification of halloysite nanotubes by chitosan (CTS) and pectin (PCN)	283:357	The study aims to investigate the modification of halloysite nanotubes by chitosan (CTS) and pectin (PCN) for forming a new pH-sensitive bionanocomposites via Layer-by-Layer method.
32057852	2	18	theme	Layer-by-Layer	412:425	arg1	method					427:432	Layer-by-Layer method	412:432	Layer-by-Layer method	412:432	The study aims to investigate the modification of halloysite nanotubes by chitosan (CTS) and pectin (PCN) for forming a new pH-sensitive bionanocomposites via Layer-by-Layer method.
32057852	2	19	theme	halloysite	303:312	arg1	nanotubes					314:322	halloysite nanotubes	303:322	halloysite nanotubes	303:322	The study aims to investigate the modification of halloysite nanotubes by chitosan (CTS) and pectin (PCN) for forming a new pH-sensitive bionanocomposites via Layer-by-Layer method.
32057852	3	20	theme	study	462:466	arg1	objective					444:452	The main objective	435:452	The main objective of this study	435:466	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	0	21	theme	biocompatible	10:22	arg1	nanocarriers					38:49	Three-ply biocompatible pH-responsive nanocarriers	0:49	Three-ply biocompatible pH-responsive nanocarriers	0:49	Three-ply biocompatible pH-responsive nanocarriers based on HNT sandwiched by chitosan/pectin layers for controlled release of phenytoin sodium.
32057852	5	22	from	release	1013:1019	arg1	fluid					1049:1053	the simulated intestinal fluid	1024:1053	the simulated intestinal fluid	1024:1053	In-vitro studies showed that prepared bionanocomposites had a low release of PHT in the simulated gastric fluid while having a more controlled release in the simulated intestinal fluid.
32057852	5	23	theme	prepared	899:906	arg1	bionanocomposites					908:924	prepared bionanocomposites	899:924	prepared bionanocomposites	899:924	In-vitro studies showed that prepared bionanocomposites had a low release of PHT in the simulated gastric fluid while having a more controlled release in the simulated intestinal fluid.
32057852	1	24	theme	revoluted	211:219	arg1	systems					244:250	revoluted advanced drug delivery systems	211:250	revoluted advanced drug delivery systems	211:250	Today, efficient straightforward biocompatible drug carriers have revoluted advanced drug delivery systems.
32057852	0	25	theme	Three-ply	0:8	arg1	nanocarriers					38:49	Three-ply biocompatible pH-responsive nanocarriers	0:49	Three-ply biocompatible pH-responsive nanocarriers	0:49	Three-ply biocompatible pH-responsive nanocarriers based on HNT sandwiched by chitosan/pectin layers for controlled release of phenytoin sodium.
32057852	4	26	theme	obtained	709:716	arg1	results					718:724	the obtained results	705:724	the obtained results	705:724	Based on the obtained results, HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2 had the best loading capacity (34.6 mg/g) compared with pure HNT (18.3 mg/g).
32057852	2	27	theme	pH-sensitive	377:388	arg1	bionanocomposites					390:406	a new pH-sensitive bionanocomposites	371:406	a new pH-sensitive bionanocomposites	371:406	The study aims to investigate the modification of halloysite nanotubes by chitosan (CTS) and pectin (PCN) for forming a new pH-sensitive bionanocomposites via Layer-by-Layer method.
32057852	5	28	theme	simulated	958:966	arg1	fluid					976:980	the simulated gastric fluid	954:980	the simulated gastric fluid	954:980	In-vitro studies showed that prepared bionanocomposites had a low release of PHT in the simulated gastric fluid while having a more controlled release in the simulated intestinal fluid.
32057852	4	29	theme	best	800:803	arg1	34.6 mg/g					823:831	34.6 mg/g	823:831	34.6 mg/g	823:831	Based on the obtained results, HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2 had the best loading capacity (34.6 mg/g) compared with pure HNT (18.3 mg/g).
32057852	4	29	theme	best	800:803	arg1	capacity					813:820	the best loading capacity	796:820	the best loading capacity (34.6 mg/g)	796:832	Based on the obtained results, HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2 had the best loading capacity (34.6 mg/g) compared with pure HNT (18.3 mg/g).
32057852	4	30	theme	HNT/CTS/PCN	727:737	arg1	nanocomposite					739:751	HNT/CTS/PCN nanocomposite	727:751	HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2	727:790	Based on the obtained results, HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2 had the best loading capacity (34.6 mg/g) compared with pure HNT (18.3 mg/g).
32057852	5	31	contain	had	926:928	arg2	release					936:942	a low release	930:942	a low release of PHT in the simulated gastric fluid	930:980	In-vitro studies showed that prepared bionanocomposites had a low release of PHT in the simulated gastric fluid while having a more controlled release in the simulated intestinal fluid.
32057852	5	31	contain	had	926:928	arg1	bionanocomposites					908:924	prepared bionanocomposites	899:924	prepared bionanocomposites	899:924	In-vitro studies showed that prepared bionanocomposites had a low release of PHT in the simulated gastric fluid while having a more controlled release in the simulated intestinal fluid.
32057852	1	32	theme	drug	230:233	arg1	systems					244:250	revoluted advanced drug delivery systems	211:250	revoluted advanced drug delivery systems	211:250	Today, efficient straightforward biocompatible drug carriers have revoluted advanced drug delivery systems.
32057852	0	33	theme	pH-responsive	24:36	arg1	nanocarriers					38:49	Three-ply biocompatible pH-responsive nanocarriers	0:49	Three-ply biocompatible pH-responsive nanocarriers	0:49	Three-ply biocompatible pH-responsive nanocarriers based on HNT sandwiched by chitosan/pectin layers for controlled release of phenytoin sodium.
32057852	0	34	theme	sodium	137:142	arg1	release					116:122	controlled release	105:122	controlled release of phenytoin sodium	105:142	Three-ply biocompatible pH-responsive nanocarriers based on HNT sandwiched by chitosan/pectin layers for controlled release of phenytoin sodium.
32057852	3	35	theme	TG	652:653	arg1	analyses					686:693	FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	630:693	FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	630:693	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	3	36	theme	phenytoin	524:532	arg1	PHT					542:544	PHT	542:544	PHT	542:544	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	3	36	theme	phenytoin	524:532	arg1	sodium					534:539	phenytoin sodium	524:539	phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	524:693	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	1	37	theme	delivery	235:242	arg1	systems					244:250	revoluted advanced drug delivery systems	211:250	revoluted advanced drug delivery systems	211:250	Today, efficient straightforward biocompatible drug carriers have revoluted advanced drug delivery systems.
32057852	5	38	theme	simulated	1028:1036	arg1	fluid					1049:1053	the simulated intestinal fluid	1024:1053	the simulated intestinal fluid	1024:1053	In-vitro studies showed that prepared bionanocomposites had a low release of PHT in the simulated gastric fluid while having a more controlled release in the simulated intestinal fluid.
32057852	1	39	theme	advanced	221:228	arg1	systems					244:250	revoluted advanced drug delivery systems	211:250	revoluted advanced drug delivery systems	211:250	Today, efficient straightforward biocompatible drug carriers have revoluted advanced drug delivery systems.
32057852	3	40	theme	main	439:442	arg1	objective					444:452	The main objective	435:452	The main objective of this study	435:466	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	1	41	contain	have	206:209	arg1	carriers					197:204	efficient straightforward biocompatible drug carriers	152:204	efficient straightforward biocompatible drug carriers	152:204	Today, efficient straightforward biocompatible drug carriers have revoluted advanced drug delivery systems.
32057852	1	41	contain	have	206:209	arg2	systems					244:250	revoluted advanced drug delivery systems	211:250	revoluted advanced drug delivery systems	211:250	Today, efficient straightforward biocompatible drug carriers have revoluted advanced drug delivery systems.
32057852	6	42	theme	PHT	1199:1201	arg1	delivery					1187:1194	the controlled drug delivery	1167:1194	the controlled drug delivery of PHT	1167:1201	Because of the loading efficiency and controlled release profile, the composites exhibited great potential for the controlled drug delivery of PHT.
32057852	0	43	theme	sandwiched	64:73	arg1	HNT					60:62	HNT	60:62	HNT sandwiched by chitosan/pectin layers for controlled release of phenytoin sodium	60:142	Three-ply biocompatible pH-responsive nanocarriers based on HNT sandwiched by chitosan/pectin layers for controlled release of phenytoin sodium.
32057852	5	44	theme	controlled	1002:1011	arg1	release					1013:1019	a more controlled release	995:1019	a more controlled release in the simulated intestinal fluid	995:1053	In-vitro studies showed that prepared bionanocomposites had a low release of PHT in the simulated gastric fluid while having a more controlled release in the simulated intestinal fluid.
32057852	4	45	theme	loading	805:811	arg1	34.6 mg/g					823:831	34.6 mg/g	823:831	34.6 mg/g	823:831	Based on the obtained results, HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2 had the best loading capacity (34.6 mg/g) compared with pure HNT (18.3 mg/g).
32057852	4	45	theme	loading	805:811	arg1	capacity					813:820	the best loading capacity	796:820	the best loading capacity (34.6 mg/g)	796:832	Based on the obtained results, HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2 had the best loading capacity (34.6 mg/g) compared with pure HNT (18.3 mg/g).
32057852	5	46	theme	In-vitro	870:877	arg1	studies					879:885	In-vitro studies	870:885	In-vitro studies	870:885	In-vitro studies showed that prepared bionanocomposites had a low release of PHT in the simulated gastric fluid while having a more controlled release in the simulated intestinal fluid.
32057852	3	47	theme	XRD	661:663	arg1	analyses					686:693	FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	630:693	FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	630:693	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	3	48	theme	nanocomposite	588:600	arg1	formation					575:583	The formation	571:583	The formation of nanocomposite	571:600	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	3	49	theme	zeta-potential	636:649	arg1	analyses					686:693	FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	630:693	FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	630:693	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	1	50	theme	efficient	152:160	arg1	carriers					197:204	efficient straightforward biocompatible drug carriers	152:204	efficient straightforward biocompatible drug carriers	152:204	Today, efficient straightforward biocompatible drug carriers have revoluted advanced drug delivery systems.
32057852	3	51	theme	FTIR	630:633	arg1	analyses					686:693	FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	630:693	FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	630:693	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	6	52	theme	release	1105:1111	arg1	profile					1113:1119	controlled release profile	1094:1119	controlled release profile	1094:1119	Because of the loading efficiency and controlled release profile, the composites exhibited great potential for the controlled drug delivery of PHT.
32057852	5	53	theme	PHT	947:949	arg1	release					936:942	a low release	930:942	a low release of PHT in the simulated gastric fluid	930:980	In-vitro studies showed that prepared bionanocomposites had a low release of PHT in the simulated gastric fluid while having a more controlled release in the simulated intestinal fluid.
32057852	3	54	theme	SEM	656:658	arg1	analyses					686:693	FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	630:693	FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	630:693	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	4	55	theme	molar	771:775	arg1	ratio					777:781	the molar ratio	767:781	the molar ratio of 2:1:2	767:790	Based on the obtained results, HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2 had the best loading capacity (34.6 mg/g) compared with pure HNT (18.3 mg/g).
32057852	3	56	dep	pH.	567:569	arg1	confirmed					606:614	confirmed	606:614	was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	602:693	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	0	57	theme	chitosan/pectin	78:92	arg1	layers					94:99	chitosan/pectin layers	78:99	chitosan/pectin layers for controlled release of phenytoin sodium	78:142	Three-ply biocompatible pH-responsive nanocarriers based on HNT sandwiched by chitosan/pectin layers for controlled release of phenytoin sodium.
32057852	4	58	theme	2:1:2	786:790	arg1	ratio					777:781	the molar ratio	767:781	the molar ratio of 2:1:2	767:790	Based on the obtained results, HNT/CTS/PCN nanocomposite prepared with the molar ratio of 2:1:2 had the best loading capacity (34.6 mg/g) compared with pure HNT (18.3 mg/g).
32057852	2	59	theme	new	373:375	arg1	bionanocomposites					390:406	a new pH-sensitive bionanocomposites	371:406	a new pH-sensitive bionanocomposites	371:406	The study aims to investigate the modification of halloysite nanotubes by chitosan (CTS) and pectin (PCN) for forming a new pH-sensitive bionanocomposites via Layer-by-Layer method.
32057852	3	60	theme	spectroscopy	673:684	arg1	analyses					686:693	FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	630:693	FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses	630:693	The main objective of this study is to improve loading efficiency and control release of phenytoin sodium (PHT) prepared in various pH. The formation of nanocomposite was confirmed through using FTIR, zeta-potential, TG, SEM, XRD, and UV spectroscopy analyses.
32057852	5	61	theme	gastric	968:974	arg1	fluid					976:980	the simulated gastric fluid	954:980	the simulated gastric fluid	954:980	In-vitro studies showed that prepared bionanocomposites had a low release of PHT in the simulated gastric fluid while having a more controlled release in the simulated intestinal fluid.
32057852	1	62	theme	straightforward	162:176	arg1	carriers					197:204	efficient straightforward biocompatible drug carriers	152:204	efficient straightforward biocompatible drug carriers	152:204	Today, efficient straightforward biocompatible drug carriers have revoluted advanced drug delivery systems.
34689077	0	0	theme	drug	94:97	arg1	microspheres					78:89	chitosan-based molecularly imprinted microspheres	41:89	chitosan-based molecularly imprinted microspheres	41:89	Release of florfenicol in seawater using chitosan-based molecularly imprinted microspheres as drug carriers.
34689077	0	0	theme	drug	94:97	arg1	carriers					99:106	drug carriers	94:106	drug carriers	94:106	Release of florfenicol in seawater using chitosan-based molecularly imprinted microspheres as drug carriers.
34689077	7	1	theme	antibiotic	1054:1063	arg1	efficacy					1038:1045	the efficacy	1034:1045	the efficacy of the antibiotic	1034:1063	The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
34689077	7	2	theme	drug	965:968	arg1	devices					979:985	drug delivery devices	965:985	drug delivery devices	965:985	The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
34689077	4	3	theme	drug	633:636	arg1	capacity					657:664	high drug loading saturation capacity	628:664	high drug loading saturation capacity	628:664	The results show that the MIPs possessed high drug loading saturation capacity and specific recognition affinity for FF.
34689077	5	4	theme	release	712:718	arg1	studies					720:726	The release studies	708:726	The release studies of MIPs as drug delivery carriers	708:760	The release studies of MIPs as drug delivery carriers were evaluated in natural seawater.
34689077	2	5	theme	chitosan-based	367:380	arg1	composites					382:391	The chitosan-based composites	363:391	The chitosan-based composites	363:391	The chitosan-based composites were characterized by scanning electron microscopy and Fourier transforms infrared spectroscopy analyses.
34689077	7	6	theme	imprinted	939:947	arg1	application					1008:1018	a promising application	996:1018	a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture	996:1130	The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
34689077	7	6	theme	imprinted	939:947	arg1	microspheres					949:960	The imprinted microspheres	935:960	The imprinted microspheres as drug delivery devices	935:985	The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
34689077	1	7	theme	drug	279:282	arg1	microspheres					151:162	Novel molecularly imprinted polymer (MIP) microspheres	109:162	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates	109:219	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	1	7	theme	drug	279:282	arg1	carriers					293:300	drug delivery carriers	279:300	drug delivery carriers	279:300	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	5	8	theme	natural	780:786	arg1	seawater					788:795	natural seawater	780:795	natural seawater	780:795	The release studies of MIPs as drug delivery carriers were evaluated in natural seawater.
34689077	0	9	from	Release	0:6	arg1	seawater					26:33	seawater	26:33	seawater	26:33	Release of florfenicol in seawater using chitosan-based molecularly imprinted microspheres as drug carriers.
34689077	6	10	theme	release	871:877	arg1	behavior					879:886	the release behavior	867:886	the release behavior	867:886	The microspheres exhibited slow sustained release profiles of FF and the release behavior conformed to the first-order kinetic equation.
34689077	1	11	theme	delivery	284:291	arg1	microspheres					151:162	Novel molecularly imprinted polymer (MIP) microspheres	109:162	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates	109:219	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	1	11	theme	delivery	284:291	arg1	carriers					293:300	drug delivery carriers	279:300	drug delivery carriers	279:300	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	4	12	theme	loading	638:644	arg1	capacity					657:664	high drug loading saturation capacity	628:664	high drug loading saturation capacity	628:664	The results show that the MIPs possessed high drug loading saturation capacity and specific recognition affinity for FF.
34689077	1	13	from	extended-release	313:328	arg1	seawater					353:360	seawater	353:360	seawater	353:360	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	2	14	theme	scanning	415:422	arg1	microscopy					433:442	scanning electron microscopy	415:442	scanning electron microscopy	415:442	The chitosan-based composites were characterized by scanning electron microscopy and Fourier transforms infrared spectroscopy analyses.
34689077	6	15	theme	FF	860:861	arg1	profiles					848:855	slow sustained release profiles	825:855	slow sustained release profiles of FF	825:861	The microspheres exhibited slow sustained release profiles of FF and the release behavior conformed to the first-order kinetic equation.
34689077	2	16	theme	electron	424:431	arg1	microscopy					433:442	scanning electron microscopy	415:442	scanning electron microscopy	415:442	The chitosan-based composites were characterized by scanning electron microscopy and Fourier transforms infrared spectroscopy analyses.
34689077	1	17	theme	eco-friendly	197:208	arg1	chitosan					185:192	functionalized chitosan	170:192	functionalized chitosan	170:192	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	1	17	theme	eco-friendly	197:208	arg1	substrates					210:219	eco-friendly substrates	197:219	eco-friendly substrates	197:219	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	4	18	contain	possessed	618:626	arg2	affinity					691:698	specific recognition affinity	670:698	specific recognition affinity	670:698	The results show that the MIPs possessed high drug loading saturation capacity and specific recognition affinity for FF.
34689077	4	18	contain	possessed	618:626	arg1	MIPs					613:616	the MIPs	609:616	the MIPs	609:616	The results show that the MIPs possessed high drug loading saturation capacity and specific recognition affinity for FF.
34689077	4	18	contain	possessed	618:626	arg2	capacity					657:664	high drug loading saturation capacity	628:664	high drug loading saturation capacity	628:664	The results show that the MIPs possessed high drug loading saturation capacity and specific recognition affinity for FF.
34689077	6	19	theme	release	840:846	arg1	profiles					848:855	slow sustained release profiles	825:855	slow sustained release profiles of FF	825:861	The microspheres exhibited slow sustained release profiles of FF and the release behavior conformed to the first-order kinetic equation.
34689077	1	20	theme	Novel	109:113	arg1	MIP					146:148	MIP	146:148	MIP	146:148	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	1	20	theme	Novel	109:113	arg1	polymer					137:143	Novel molecularly imprinted polymer	109:143	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates	109:219	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	2	21	theme	infrared	467:474	arg1	analyses					489:496	infrared spectroscopy analyses	467:496	infrared spectroscopy analyses	467:496	The chitosan-based composites were characterized by scanning electron microscopy and Fourier transforms infrared spectroscopy analyses.
34689077	2	22	theme	spectroscopy	476:487	arg1	analyses					489:496	infrared spectroscopy analyses	467:496	infrared spectroscopy analyses	467:496	The chitosan-based composites were characterized by scanning electron microscopy and Fourier transforms infrared spectroscopy analyses.
34689077	6	23	theme	first-order	905:915	arg1	equation					925:932	the first-order kinetic equation	901:932	the first-order kinetic equation	901:932	The microspheres exhibited slow sustained release profiles of FF and the release behavior conformed to the first-order kinetic equation.
34689077	7	24	theme	excess	1107:1112	arg1	FF					1114:1115	excess FF	1107:1115	excess FF in aquaculture	1107:1130	The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
34689077	1	25	theme	functionalized	170:183	arg1	chitosan					185:192	functionalized chitosan	170:192	functionalized chitosan	170:192	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	1	25	theme	functionalized	170:183	arg1	substrates					210:219	eco-friendly substrates	197:219	eco-friendly substrates	197:219	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	3	26	theme	adsorption	522:531	arg1	capability					533:542	adsorption capability	522:542	adsorption capability	522:542	The swelling behavior, adsorption capability, and selectivity for FF were investigated.
34689077	2	27	dep	Fourier	448:454	arg1	transforms					456:465	transforms	456:465	transforms	456:465	The chitosan-based composites were characterized by scanning electron microscopy and Fourier transforms infrared spectroscopy analyses.
34689077	3	28	theme	swelling	503:510	arg1	behavior					512:519	swelling behavior	503:519	swelling behavior	503:519	The swelling behavior, adsorption capability, and selectivity for FF were investigated.
34689077	1	29	theme	florfenicol	333:343	arg1	extended-release					313:328	extended-release	313:328	extended-release of florfenicol (FF) in seawater	313:360	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	4	30	theme	high	628:631	arg1	capacity					657:664	high drug loading saturation capacity	628:664	high drug loading saturation capacity	628:664	The results show that the MIPs possessed high drug loading saturation capacity and specific recognition affinity for FF.
34689077	6	31	theme	sustained	830:838	arg1	profiles					848:855	slow sustained release profiles	825:855	slow sustained release profiles of FF	825:861	The microspheres exhibited slow sustained release profiles of FF and the release behavior conformed to the first-order kinetic equation.
34689077	1	32	theme	surface	238:244	arg1	method					257:262	surface imprinting method	238:262	surface imprinting method	238:262	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	5	33	theme	MIPs	731:734	arg1	studies					720:726	The release studies	708:726	The release studies of MIPs as drug delivery carriers	708:760	The release studies of MIPs as drug delivery carriers were evaluated in natural seawater.
34689077	6	34	theme	kinetic	917:923	arg1	equation					925:932	the first-order kinetic equation	901:932	the first-order kinetic equation	901:932	The microspheres exhibited slow sustained release profiles of FF and the release behavior conformed to the first-order kinetic equation.
34689077	6	35	theme	slow	825:828	arg1	profiles					848:855	slow sustained release profiles	825:855	slow sustained release profiles of FF	825:861	The microspheres exhibited slow sustained release profiles of FF and the release behavior conformed to the first-order kinetic equation.
34689077	1	36	theme	imprinted	127:135	arg1	MIP					146:148	MIP	146:148	MIP	146:148	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	1	36	theme	imprinted	127:135	arg1	polymer					137:143	Novel molecularly imprinted polymer	109:143	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates	109:219	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	0	37	theme	chitosan-based	41:54	arg1	microspheres					78:89	chitosan-based molecularly imprinted microspheres	41:89	chitosan-based molecularly imprinted microspheres	41:89	Release of florfenicol in seawater using chitosan-based molecularly imprinted microspheres as drug carriers.
34689077	0	37	theme	chitosan-based	41:54	arg1	carriers					99:106	drug carriers	94:106	drug carriers	94:106	Release of florfenicol in seawater using chitosan-based molecularly imprinted microspheres as drug carriers.
34689077	4	38	theme	saturation	646:655	arg1	capacity					657:664	high drug loading saturation capacity	628:664	high drug loading saturation capacity	628:664	The results show that the MIPs possessed high drug loading saturation capacity and specific recognition affinity for FF.
34689077	1	39	theme	polymer	137:143	arg1	microspheres					151:162	Novel molecularly imprinted polymer (MIP) microspheres	109:162	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates	109:219	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	1	39	theme	polymer	137:143	arg1	carriers					293:300	drug delivery carriers	279:300	drug delivery carriers	279:300	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	7	40	theme	promising	998:1006	arg1	application					1008:1018	a promising application	996:1018	a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture	996:1130	The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
34689077	7	40	theme	promising	998:1006	arg1	microspheres					949:960	The imprinted microspheres	935:960	The imprinted microspheres as drug delivery devices	935:985	The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
34689077	5	41	theme	drug	739:742	arg1	carriers					753:760	drug delivery carriers	739:760	drug delivery carriers	739:760	The release studies of MIPs as drug delivery carriers were evaluated in natural seawater.
34689077	7	42	theme	ecological	1086:1095	arg1	system					1097:1102	the ecological system	1082:1102	the ecological system	1082:1102	The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
34689077	1	43	theme	imprinting	246:255	arg1	method					257:262	surface imprinting method	238:262	surface imprinting method	238:262	Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater.
34689077	5	44	theme	delivery	744:751	arg1	carriers					753:760	drug delivery carriers	739:760	drug delivery carriers	739:760	The release studies of MIPs as drug delivery carriers were evaluated in natural seawater.
34689077	3	45	dep	behavior	512:519	arg1	The					499:501	The	499:501	The	499:501	The swelling behavior, adsorption capability, and selectivity for FF were investigated.
34689077	7	46	theme	delivery	970:977	arg1	devices					979:985	drug delivery devices	965:985	drug delivery devices	965:985	The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
34689077	7	47	from	FF	1114:1115	arg1	aquaculture					1120:1130	aquaculture	1120:1130	aquaculture	1120:1130	The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
34689077	2	48	dep	microscopy	433:442	arg1	analyses					489:496	infrared spectroscopy analyses	467:496	infrared spectroscopy analyses	467:496	The chitosan-based composites were characterized by scanning electron microscopy and Fourier transforms infrared spectroscopy analyses.
34689077	4	49	theme	recognition	679:689	arg1	affinity					691:698	specific recognition affinity	670:698	specific recognition affinity	670:698	The results show that the MIPs possessed high drug loading saturation capacity and specific recognition affinity for FF.
34689077	0	50	theme	imprinted	68:76	arg1	microspheres					78:89	chitosan-based molecularly imprinted microspheres	41:89	chitosan-based molecularly imprinted microspheres	41:89	Release of florfenicol in seawater using chitosan-based molecularly imprinted microspheres as drug carriers.
34689077	0	50	theme	imprinted	68:76	arg1	carriers					99:106	drug carriers	94:106	drug carriers	94:106	Release of florfenicol in seawater using chitosan-based molecularly imprinted microspheres as drug carriers.
34689077	0	51	theme	florfenicol	11:21	arg1	Release					0:6	Release	0:6	Release of florfenicol in seawater	0:33	Release of florfenicol in seawater using chitosan-based molecularly imprinted microspheres as drug carriers.
34689077	4	52	theme	specific	670:677	arg1	affinity					691:698	specific recognition affinity	670:698	specific recognition affinity	670:698	The results show that the MIPs possessed high drug loading saturation capacity and specific recognition affinity for FF.
33357888	0	0	theme	oil	87:89	arg1	emulsion					65:72	a Pickering emulsion	53:72	a Pickering emulsion of essential oil	53:89	Larvicidal composite alginate hydrogel combined with a Pickering emulsion of essential oil.
33357888	1	1	with	volatile	201:208	arg1	water					230:234	water	230:234	water	230:234	Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water.
33357888	4	2	theme	composite	633:641	arg1	beads					652:656	the SA-PE composite hydrogel beads	623:656	the SA-PE composite hydrogel beads	623:656	The larvicidal performance of the SA-PE composite hydrogel beads is investigated with Aedes albopictus (Skuse) larvae.
33357888	0	3	theme	essential	77:85	arg1	oil					87:89	essential oil	77:89	essential oil	77:89	Larvicidal composite alginate hydrogel combined with a Pickering emulsion of essential oil.
33357888	4	4	theme	SA-PE	627:631	arg1	beads					652:656	the SA-PE composite hydrogel beads	623:656	the SA-PE composite hydrogel beads	623:656	The larvicidal performance of the SA-PE composite hydrogel beads is investigated with Aedes albopictus (Skuse) larvae.
33357888	3	5	theme	confocal	451:458	arg1	characterizations					472:488	confocal microscopic characterizations	451:488	confocal microscopic characterizations	451:488	The incorporation of PEs with SA is confirmed with FTIR, XRD, SEM and confocal microscopic characterizations and the release behavior is monitored to understand the time-dependent biological activity of the EOs.
33357888	5	6	dep	%	812:812	arg1	1.0					808:810	1.0	808:810	1.0	808:810	The larvicidal activity is higher for SA/PE hydrogel beads prepared at 0.5 % CaCl2 than 0.75 or 1.0 % CaCl2 due to their higher release rate.
33357888	5	6	dep	%	812:812	arg1	0.75					800:803	0.75	800:803	0.75	800:803	The larvicidal activity is higher for SA/PE hydrogel beads prepared at 0.5 % CaCl2 than 0.75 or 1.0 % CaCl2 due to their higher release rate.
33357888	2	7	theme	Pickering	251:259	arg1	PE					271:272	PE	271:272	PE	271:272	S-CNCs form a Pickering emulsion (PE) with EOs and the micron-scale PEs are embedded in sodium alginate (SA) to form macroscale hydrogel beads.
33357888	2	7	theme	Pickering	251:259	arg1	emulsion					261:268	a Pickering emulsion	249:268	a Pickering emulsion (PE)	249:273	S-CNCs form a Pickering emulsion (PE) with EOs and the micron-scale PEs are embedded in sodium alginate (SA) to form macroscale hydrogel beads.
33357888	4	8	theme	beads	652:656	arg1	performance					608:618	The larvicidal performance	593:618	The larvicidal performance of the SA-PE composite hydrogel beads	593:656	The larvicidal performance of the SA-PE composite hydrogel beads is investigated with Aedes albopictus (Skuse) larvae.
33357888	1	9	used	used	142:145	arg2	nanocrystals					113:124	Sulfonated cellulose nanocrystals	92:124	Sulfonated cellulose nanocrystals (S-CNCs)	92:133	Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water.
33357888	1	9	used	used	142:145	arg2	S-CNCs					127:132	S-CNCs	127:132	S-CNCs	127:132	Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water.
33357888	1	10	theme	thyme	162:166	arg1	EO					189:190	EO	189:190	EO	189:190	Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water.
33357888	1	10	theme	thyme	162:166	arg1	oil					184:186	thyme white essential oil	162:186	thyme white essential oil (EO) that is volatile and immiscible with water	162:234	Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water.
33357888	1	11	theme	white	168:172	arg1	EO					189:190	EO	189:190	EO	189:190	Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water.
33357888	1	11	theme	white	168:172	arg1	oil					184:186	thyme white essential oil	162:186	thyme white essential oil (EO) that is volatile and immiscible with water	162:234	Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water.
33357888	0	12	theme	composite	11:19	arg1	hydrogel					30:37	Larvicidal composite alginate hydrogel	0:37	Larvicidal composite alginate hydrogel	0:37	Larvicidal composite alginate hydrogel combined with a Pickering emulsion of essential oil.
33357888	5	13	theme	release	840:846	arg1	rate					848:851	their higher release rate	827:851	their higher release rate	827:851	The larvicidal activity is higher for SA/PE hydrogel beads prepared at 0.5 % CaCl2 than 0.75 or 1.0 % CaCl2 due to their higher release rate.
33357888	1	14	theme	essential	174:182	arg1	EO					189:190	EO	189:190	EO	189:190	Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water.
33357888	1	14	theme	essential	174:182	arg1	oil					184:186	thyme white essential oil	162:186	thyme white essential oil (EO) that is volatile and immiscible with water	162:234	Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water.
33357888	0	15	theme	Larvicidal	0:9	arg1	hydrogel					30:37	Larvicidal composite alginate hydrogel	0:37	Larvicidal composite alginate hydrogel	0:37	Larvicidal composite alginate hydrogel combined with a Pickering emulsion of essential oil.
33357888	1	16	theme	Sulfonated	92:101	arg1	S-CNCs					127:132	S-CNCs	127:132	S-CNCs	127:132	Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water.
33357888	1	16	theme	Sulfonated	92:101	arg1	nanocrystals					113:124	Sulfonated cellulose nanocrystals	92:124	Sulfonated cellulose nanocrystals (S-CNCs)	92:133	Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water.
33357888	2	17	theme	sodium	325:330	arg1	SA					342:343	SA	342:343	SA	342:343	S-CNCs form a Pickering emulsion (PE) with EOs and the micron-scale PEs are embedded in sodium alginate (SA) to form macroscale hydrogel beads.
33357888	2	17	theme	sodium	325:330	arg1	alginate					332:339	sodium alginate	325:339	sodium alginate (SA)	325:344	S-CNCs form a Pickering emulsion (PE) with EOs and the micron-scale PEs are embedded in sodium alginate (SA) to form macroscale hydrogel beads.
33357888	5	18	theme	SA/PE	750:754	arg1	beads					765:769	SA/PE hydrogel beads	750:769	SA/PE hydrogel beads prepared at 0.5 % CaCl2	750:793	The larvicidal activity is higher for SA/PE hydrogel beads prepared at 0.5 % CaCl2 than 0.75 or 1.0 % CaCl2 due to their higher release rate.
33357888	3	19	with	incorporation	385:397	arg1	SA					411:412	SA	411:412	SA	411:412	The incorporation of PEs with SA is confirmed with FTIR, XRD, SEM and confocal microscopic characterizations and the release behavior is monitored to understand the time-dependent biological activity of the EOs.
33357888	2	20	from	embedded	313:320	arg1	SA					342:343	SA	342:343	SA	342:343	S-CNCs form a Pickering emulsion (PE) with EOs and the micron-scale PEs are embedded in sodium alginate (SA) to form macroscale hydrogel beads.
33357888	2	20	from	embedded	313:320	arg1	alginate					332:339	sodium alginate	325:339	sodium alginate (SA)	325:344	S-CNCs form a Pickering emulsion (PE) with EOs and the micron-scale PEs are embedded in sodium alginate (SA) to form macroscale hydrogel beads.
33357888	1	21	theme	cellulose	103:111	arg1	S-CNCs					127:132	S-CNCs	127:132	S-CNCs	127:132	Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water.
33357888	1	21	theme	cellulose	103:111	arg1	nanocrystals					113:124	Sulfonated cellulose nanocrystals	92:124	Sulfonated cellulose nanocrystals (S-CNCs)	92:133	Sulfonated cellulose nanocrystals (S-CNCs) can be used to encapsulate thyme white essential oil (EO) that is volatile and immiscible with water.
33357888	2	22	theme	macroscale	354:363	arg1	beads					374:378	macroscale hydrogel beads	354:378	macroscale hydrogel beads	354:378	S-CNCs form a Pickering emulsion (PE) with EOs and the micron-scale PEs are embedded in sodium alginate (SA) to form macroscale hydrogel beads.
33357888	2	23	theme	hydrogel	365:372	arg1	beads					374:378	macroscale hydrogel beads	354:378	macroscale hydrogel beads	354:378	S-CNCs form a Pickering emulsion (PE) with EOs and the micron-scale PEs are embedded in sodium alginate (SA) to form macroscale hydrogel beads.
33357888	4	24	theme	albopictus	685:694	arg1	larvae					704:709	Aedes albopictus (Skuse) larvae	679:709	Aedes albopictus (Skuse) larvae	679:709	The larvicidal performance of the SA-PE composite hydrogel beads is investigated with Aedes albopictus (Skuse) larvae.
33357888	3	25	theme	EOs	588:590	arg1	activity					572:579	the time-dependent biological activity	542:579	the time-dependent biological activity of the EOs	542:590	The incorporation of PEs with SA is confirmed with FTIR, XRD, SEM and confocal microscopic characterizations and the release behavior is monitored to understand the time-dependent biological activity of the EOs.
33357888	4	26	theme	larvicidal	597:606	arg1	performance					608:618	The larvicidal performance	593:618	The larvicidal performance of the SA-PE composite hydrogel beads	593:656	The larvicidal performance of the SA-PE composite hydrogel beads is investigated with Aedes albopictus (Skuse) larvae.
33357888	5	27	theme	%	787:787	arg1	CaCl2					789:793	0.5 % CaCl2	783:793	0.5 % CaCl2	783:793	The larvicidal activity is higher for SA/PE hydrogel beads prepared at 0.5 % CaCl2 than 0.75 or 1.0 % CaCl2 due to their higher release rate.
33357888	5	28	theme	larvicidal	716:725	arg1	activity					727:734	The larvicidal activity	712:734	The larvicidal activity	712:734	The larvicidal activity is higher for SA/PE hydrogel beads prepared at 0.5 % CaCl2 than 0.75 or 1.0 % CaCl2 due to their higher release rate.
33357888	5	28	theme	larvicidal	716:725	arg1	higher					739:744	higher	739:744	higher	739:744	The larvicidal activity is higher for SA/PE hydrogel beads prepared at 0.5 % CaCl2 than 0.75 or 1.0 % CaCl2 due to their higher release rate.
33357888	2	29	from	alginate	332:339	arg1	embedded					313:320	embedded	313:320	embedded	313:320	S-CNCs form a Pickering emulsion (PE) with EOs and the micron-scale PEs are embedded in sodium alginate (SA) to form macroscale hydrogel beads.
33357888	2	29	from	alginate	332:339	arg1	PEs					305:307	the micron-scale PEs	288:307	the micron-scale PEs	288:307	S-CNCs form a Pickering emulsion (PE) with EOs and the micron-scale PEs are embedded in sodium alginate (SA) to form macroscale hydrogel beads.
33357888	5	30	theme	0.5	783:785	arg1	%					787:787	%	787:787	%	787:787	The larvicidal activity is higher for SA/PE hydrogel beads prepared at 0.5 % CaCl2 than 0.75 or 1.0 % CaCl2 due to their higher release rate.
33357888	0	31	theme	Pickering	55:63	arg1	emulsion					65:72	a Pickering emulsion	53:72	a Pickering emulsion of essential oil	53:89	Larvicidal composite alginate hydrogel combined with a Pickering emulsion of essential oil.
33357888	5	32	theme	hydrogel	756:763	arg1	beads					765:769	SA/PE hydrogel beads	750:769	SA/PE hydrogel beads prepared at 0.5 % CaCl2	750:793	The larvicidal activity is higher for SA/PE hydrogel beads prepared at 0.5 % CaCl2 than 0.75 or 1.0 % CaCl2 due to their higher release rate.
33357888	5	33	dep	CaCl2	814:818	arg1	%					812:812	%	812:812	%	812:812	The larvicidal activity is higher for SA/PE hydrogel beads prepared at 0.5 % CaCl2 than 0.75 or 1.0 % CaCl2 due to their higher release rate.
33357888	2	34	theme	micron-scale	292:303	arg1	embedded					313:320	embedded	313:320	embedded	313:320	S-CNCs form a Pickering emulsion (PE) with EOs and the micron-scale PEs are embedded in sodium alginate (SA) to form macroscale hydrogel beads.
33357888	2	34	theme	micron-scale	292:303	arg1	PEs					305:307	the micron-scale PEs	288:307	the micron-scale PEs	288:307	S-CNCs form a Pickering emulsion (PE) with EOs and the micron-scale PEs are embedded in sodium alginate (SA) to form macroscale hydrogel beads.
33357888	4	35	theme	hydrogel	643:650	arg1	beads					652:656	the SA-PE composite hydrogel beads	623:656	the SA-PE composite hydrogel beads	623:656	The larvicidal performance of the SA-PE composite hydrogel beads is investigated with Aedes albopictus (Skuse) larvae.
33357888	3	36	theme	time-dependent	546:559	arg1	activity					572:579	the time-dependent biological activity	542:579	the time-dependent biological activity of the EOs	542:590	The incorporation of PEs with SA is confirmed with FTIR, XRD, SEM and confocal microscopic characterizations and the release behavior is monitored to understand the time-dependent biological activity of the EOs.
33357888	3	37	dep	confocal	451:458	arg1	microscopic					460:470	microscopic	460:470	microscopic	460:470	The incorporation of PEs with SA is confirmed with FTIR, XRD, SEM and confocal microscopic characterizations and the release behavior is monitored to understand the time-dependent biological activity of the EOs.
33357888	3	38	theme	biological	561:570	arg1	activity					572:579	the time-dependent biological activity	542:579	the time-dependent biological activity of the EOs	542:590	The incorporation of PEs with SA is confirmed with FTIR, XRD, SEM and confocal microscopic characterizations and the release behavior is monitored to understand the time-dependent biological activity of the EOs.
33357888	5	39	theme	higher	833:838	arg1	rate					848:851	their higher release rate	827:851	their higher release rate	827:851	The larvicidal activity is higher for SA/PE hydrogel beads prepared at 0.5 % CaCl2 than 0.75 or 1.0 % CaCl2 due to their higher release rate.
33357888	3	40	theme	PEs	402:404	arg1	incorporation					385:397	The incorporation	381:397	The incorporation of PEs with SA	381:412	The incorporation of PEs with SA is confirmed with FTIR, XRD, SEM and confocal microscopic characterizations and the release behavior is monitored to understand the time-dependent biological activity of the EOs.
33357888	0	41	theme	alginate	21:28	arg1	hydrogel					30:37	Larvicidal composite alginate hydrogel	0:37	Larvicidal composite alginate hydrogel	0:37	Larvicidal composite alginate hydrogel combined with a Pickering emulsion of essential oil.
33357888	3	42	theme	release	498:504	arg1	behavior					506:513	the release behavior	494:513	the release behavior	494:513	The incorporation of PEs with SA is confirmed with FTIR, XRD, SEM and confocal microscopic characterizations and the release behavior is monitored to understand the time-dependent biological activity of the EOs.
33663840	10	0	theme	functional	1824:1833	arg1	food					1835:1838	a functional food	1822:1838	a functional food for alleviating constipation	1822:1867	These findings demonstrated that the synbiotic yogurt can be considered a functional food for alleviating constipation.
33663840	1	1	theme	factor	165:170	arg1	pathway					184:190	the stem cell factor (SCF)/c-Kit pathway	151:190	the stem cell factor (SCF)/c-Kit pathway	151:190	lactis BB12 alleviates constipation in mice by modulating the stem cell factor (SCF)/c-Kit pathway and gut microbiota.
33663840	7	2	theme	factor	1324:1329	arg1	/c-Kit					1336:1341	the stem cell factor (SCF)/c-Kit	1310:1341	the stem cell factor (SCF)/c-Kit pathway	1310:1349	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	8	3	dep	Genes	1459:1463	arg1	pathways					1484:1491	pathways	1484:1491	pathways	1484:1491	Additionally, YBK2.0 treatment significantly regulated the community composition and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of gut microbiota, which were positively correlated with physiological parameters of constipation.
33663840	8	4	theme	Genomes	1469:1475	arg1	composition					1421:1431	community composition	1411:1431	community composition	1411:1431	Additionally, YBK2.0 treatment significantly regulated the community composition and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of gut microbiota, which were positively correlated with physiological parameters of constipation.
33663840	5	5	theme	yogurt	575:580	arg1	administration					557:570	administration	557:570	administration of yogurt containing 2.0% KMOS and BB12 (YBK2.0)	557:619	Following administration of yogurt containing 2.0% KMOS and BB12 (YBK2.0), black fecal weight and number and gastrointestinal transit rate increased by 97.5, 106.3, and 55.7%, respectively, compared with the model group.
33663840	6	6	theme	vasoactive	984:993	arg1	peptide					1006:1012	vasoactive intestinal peptide	984:1012	vasoactive intestinal peptide	984:1012	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	6	theme	vasoactive	984:993	arg1	neurotransmitters					965:981	inhibitory neurotransmitters	954:981	inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine)	954:1046	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	9	7	theme	fecal	1679:1683	arg1	excretion					1685:1693	fecal excretion	1679:1693	fecal excretion	1679:1693	Thus, supplementation with synbiotic yogurt composed of KMOS and BB12 could facilitate fecal excretion by regulating related pathways and the gut microbiota.
33663840	8	8	theme	physiological	1550:1562	arg1	parameters					1564:1573	physiological parameters	1550:1573	physiological parameters of constipation	1550:1589	Additionally, YBK2.0 treatment significantly regulated the community composition and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of gut microbiota, which were positively correlated with physiological parameters of constipation.
33663840	2	9	theme	gut	283:285	arg1	microbiota					287:296	the gut microbiota	279:296	the gut microbiota	279:296	Synbiotic dietary supplements, as an effective means of regulating the gut microbiota, may have a beneficial effect on constipation.
33663840	3	10	theme	synbiotic	381:389	arg1	KMOS					441:444	KMOS	441:444	KMOS	441:444	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	3	10	theme	synbiotic	381:389	arg1	oligosaccharides					423:438	synbiotic yogurt containing konjac mannan oligosaccharides	381:438	synbiotic yogurt containing konjac mannan oligosaccharides (KMOS)	381:445	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	7	11	theme	/c-Kit	1336:1341	arg1	pathway					1343:1349	the stem cell factor (SCF)/c-Kit pathway	1310:1349	the stem cell factor (SCF)/c-Kit pathway	1310:1349	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	5	12	theme	black	622:626	arg1	weight					634:639	black fecal weight	622:639	black fecal weight	622:639	Following administration of yogurt containing 2.0% KMOS and BB12 (YBK2.0), black fecal weight and number and gastrointestinal transit rate increased by 97.5, 106.3, and 55.7%, respectively, compared with the model group.
33663840	5	13	theme	2.0	593:595	arg1	%					596:596	%	596:596	%	596:596	Following administration of yogurt containing 2.0% KMOS and BB12 (YBK2.0), black fecal weight and number and gastrointestinal transit rate increased by 97.5, 106.3, and 55.7%, respectively, compared with the model group.
33663840	6	14	theme	intestinal	995:1004	arg1	peptide					1006:1012	vasoactive intestinal peptide	984:1012	vasoactive intestinal peptide	984:1012	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	14	theme	intestinal	995:1004	arg1	neurotransmitters					965:981	inhibitory neurotransmitters	954:981	inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine)	954:1046	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	9	15	theme	synbiotic	1619:1627	arg1	yogurt					1629:1634	synbiotic yogurt	1619:1634	synbiotic yogurt composed of KMOS and BB12	1619:1660	Thus, supplementation with synbiotic yogurt composed of KMOS and BB12 could facilitate fecal excretion by regulating related pathways and the gut microbiota.
33663840	6	16	from	levels	774:779	arg1	group					871:875	the YBK2.0 group	860:875	the YBK2.0 group	860:875	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	7	17	theme	yogurt	1084:1089	arg1	supplementation					1091:1105	synbiotic yogurt supplementation	1074:1105	synbiotic yogurt supplementation	1074:1105	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	6	18	theme	substance	825:833	arg1	P					835:835	substance P	825:835	substance P	825:835	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	18	theme	substance	825:833	arg1	neurotransmitters					797:813	excitability neurotransmitters	784:813	excitability neurotransmitters (motilin, substance P, and acetylcholine)	784:855	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	4	19	from	BB12	488:491	arg1	mice					523:526	constipated Kunming mice	503:526	constipated Kunming mice (the model group)	503:544	lactis BB12 (BB12) on constipated Kunming mice (the model group).
33663840	4	19	from	BB12	488:491	arg1	group					539:543	the model group	529:543	the model group	529:543	lactis BB12 (BB12) on constipated Kunming mice (the model group).
33663840	3	20	theme	animalis	467:474	arg1	ssp					476:478	Bifidobacterium animalis ssp	451:478	Bifidobacterium animalis ssp	451:478	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	7	21	theme	stem	1314:1317	arg1	SCF					1332:1334	SCF	1332:1334	SCF	1332:1334	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	7	21	theme	stem	1314:1317	arg1	factor					1324:1329	the stem cell factor	1310:1329	the stem cell factor (SCF)/c-Kit pathway	1310:1349	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	1	22	theme	/c-Kit	177:182	arg1	pathway					184:190	the stem cell factor (SCF)/c-Kit pathway	151:190	the stem cell factor (SCF)/c-Kit pathway	151:190	lactis BB12 alleviates constipation in mice by modulating the stem cell factor (SCF)/c-Kit pathway and gut microbiota.
33663840	6	23	theme	serum	938:942	arg1	levels					944:949	serum levels	938:949	serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine)	938:1046	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	7	24	theme	synbiotic	1074:1082	arg1	supplementation					1091:1105	synbiotic yogurt supplementation	1074:1105	synbiotic yogurt supplementation	1074:1105	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	1	25	theme	lactis	93:98	arg1	BB12					100:103	lactis BB12	93:103	lactis BB12	93:103	lactis BB12 alleviates constipation in mice by modulating the stem cell factor (SCF)/c-Kit pathway and gut microbiota.
33663840	6	26	theme	neurotransmitters	965:981	arg1	levels					944:949	serum levels	938:949	serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine)	938:1046	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	9	27	theme	related	1709:1715	arg1	pathways					1717:1724	related pathways	1709:1724	related pathways	1709:1724	Thus, supplementation with synbiotic yogurt composed of KMOS and BB12 could facilitate fecal excretion by regulating related pathways and the gut microbiota.
33663840	4	28	theme	lactis	481:486	arg1	BB12					494:497	BB12	494:497	BB12	494:497	lactis BB12 (BB12) on constipated Kunming mice (the model group).
33663840	4	28	theme	lactis	481:486	arg1	BB12					488:491	lactis BB12	481:491	lactis BB12 (BB12) on constipated Kunming mice (the model group).	481:545	lactis BB12 (BB12) on constipated Kunming mice (the model group).
33663840	7	29	theme	receptor	1183:1190	arg1	expression					1139:1148	the expression	1135:1148	the expression of vasoactive intestinal peptide receptor 1 (VIPR1)	1135:1200	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	7	30	theme	pathway	1343:1349	arg1	expression					1296:1305	the expression	1292:1305	the expression of the stem cell factor (SCF)/c-Kit pathway	1292:1349	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	3	31	theme	mannan	416:421	arg1	KMOS					441:444	KMOS	441:444	KMOS	441:444	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	3	31	theme	mannan	416:421	arg1	oligosaccharides					423:438	synbiotic yogurt containing konjac mannan oligosaccharides	381:438	synbiotic yogurt containing konjac mannan oligosaccharides (KMOS)	381:445	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	0	32	theme	Synbiotic	0:8	arg1	yogurt					10:15	Synbiotic yogurt	0:15	Synbiotic yogurt	0:15	Synbiotic yogurt containing konjac mannan oligosaccharides and Bifidobacterium animalis ssp.
33663840	4	33	theme	model	533:537	arg1	mice					523:526	constipated Kunming mice	503:526	constipated Kunming mice (the model group)	503:544	lactis BB12 (BB12) on constipated Kunming mice (the model group).
33663840	4	33	theme	model	533:537	arg1	group					539:543	the model group	529:543	the model group	529:543	lactis BB12 (BB12) on constipated Kunming mice (the model group).
33663840	10	34	theme	synbiotic	1787:1795	arg1	yogurt					1797:1802	the synbiotic yogurt	1783:1802	the synbiotic yogurt	1783:1802	These findings demonstrated that the synbiotic yogurt can be considered a functional food for alleviating constipation.
33663840	9	35	theme	gut	1734:1736	arg1	microbiota					1738:1747	the gut microbiota	1730:1747	the gut microbiota	1730:1747	Thus, supplementation with synbiotic yogurt composed of KMOS and BB12 could facilitate fecal excretion by regulating related pathways and the gut microbiota.
33663840	3	36	theme	oligosaccharides	423:438	arg1	effects					370:376	the effects	366:376	the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS)	366:445	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	3	36	theme	oligosaccharides	423:438	arg1	ssp					476:478	Bifidobacterium animalis ssp	451:478	Bifidobacterium animalis ssp	451:478	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	0	37	theme	konjac	28:33	arg1	oligosaccharides					42:57	konjac mannan oligosaccharides	28:57	konjac mannan oligosaccharides	28:57	Synbiotic yogurt containing konjac mannan oligosaccharides and Bifidobacterium animalis ssp.
33663840	5	38	theme	%	596:596	arg1	KMOS					598:601	2.0% KMOS	593:601	2.0% KMOS	593:601	Following administration of yogurt containing 2.0% KMOS and BB12 (YBK2.0), black fecal weight and number and gastrointestinal transit rate increased by 97.5, 106.3, and 55.7%, respectively, compared with the model group.
33663840	3	39	theme	Bifidobacterium	451:465	arg1	ssp					476:478	Bifidobacterium animalis ssp	451:478	Bifidobacterium animalis ssp	451:478	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	5	40	theme	model	755:759	arg1	group					761:765	the model group	751:765	the model group	751:765	Following administration of yogurt containing 2.0% KMOS and BB12 (YBK2.0), black fecal weight and number and gastrointestinal transit rate increased by 97.5, 106.3, and 55.7%, respectively, compared with the model group.
33663840	8	41	theme	community	1411:1419	arg1	composition					1421:1431	community composition	1411:1431	community composition	1411:1431	Additionally, YBK2.0 treatment significantly regulated the community composition and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of gut microbiota, which were positively correlated with physiological parameters of constipation.
33663840	5	42	theme	gastrointestinal	656:671	arg1	rate					681:684	gastrointestinal transit rate	656:684	gastrointestinal transit rate	656:684	Following administration of yogurt containing 2.0% KMOS and BB12 (YBK2.0), black fecal weight and number and gastrointestinal transit rate increased by 97.5, 106.3, and 55.7%, respectively, compared with the model group.
33663840	6	43	dep	neurotransmitters	965:981	arg1	peptide					1006:1012	vasoactive intestinal peptide	984:1012	vasoactive intestinal peptide	984:1012	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	43	dep	neurotransmitters	965:981	arg1	oxide					1022:1026	nitric oxide	1015:1026	nitric oxide	1015:1026	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	43	dep	neurotransmitters	965:981	arg1	acetylcholine					1033:1045	acetylcholine	1033:1045	acetylcholine	1033:1045	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	43	dep	neurotransmitters	965:981	arg1	neurotransmitters					965:981	inhibitory neurotransmitters	954:981	inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine)	954:1046	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	1	44	theme	gut	196:198	arg1	microbiota					200:209	gut microbiota	196:209	gut microbiota	196:209	lactis BB12 alleviates constipation in mice by modulating the stem cell factor (SCF)/c-Kit pathway and gut microbiota.
33663840	3	45	theme	containing	398:407	arg1	KMOS					441:444	KMOS	441:444	KMOS	441:444	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	3	45	theme	containing	398:407	arg1	oligosaccharides					423:438	synbiotic yogurt containing konjac mannan oligosaccharides	381:438	synbiotic yogurt containing konjac mannan oligosaccharides (KMOS)	381:445	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	8	46	theme	Genes	1459:1463	arg1	composition					1421:1431	community composition	1411:1431	community composition	1411:1431	Additionally, YBK2.0 treatment significantly regulated the community composition and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of gut microbiota, which were positively correlated with physiological parameters of constipation.
33663840	5	47	theme	transit	673:679	arg1	rate					681:684	gastrointestinal transit rate	656:684	gastrointestinal transit rate	656:684	Following administration of yogurt containing 2.0% KMOS and BB12 (YBK2.0), black fecal weight and number and gastrointestinal transit rate increased by 97.5, 106.3, and 55.7%, respectively, compared with the model group.
33663840	6	48	theme	neurotransmitters	797:813	arg1	levels					774:779	Serum levels	768:779	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group	768:875	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	8	49	theme	gut	1496:1498	arg1	microbiota					1500:1509	gut microbiota	1496:1509	gut microbiota	1496:1509	Additionally, YBK2.0 treatment significantly regulated the community composition and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of gut microbiota, which were positively correlated with physiological parameters of constipation.
33663840	7	50	theme	receptor	1246:1253	arg1	expression					1222:1231	the expression	1218:1231	the expression of serotonin receptor 4 (5-HT4) in the colon	1218:1276	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	0	51	theme	mannan	35:40	arg1	oligosaccharides					42:57	konjac mannan oligosaccharides	28:57	konjac mannan oligosaccharides	28:57	Synbiotic yogurt containing konjac mannan oligosaccharides and Bifidobacterium animalis ssp.
33663840	4	52	theme	Kunming	515:521	arg1	mice					523:526	constipated Kunming mice	503:526	constipated Kunming mice (the model group)	503:544	lactis BB12 (BB12) on constipated Kunming mice (the model group).
33663840	4	52	theme	Kunming	515:521	arg1	group					539:543	the model group	529:543	the model group	529:543	lactis BB12 (BB12) on constipated Kunming mice (the model group).
33663840	3	53	theme	konjac	409:414	arg1	KMOS					441:444	KMOS	441:444	KMOS	441:444	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	3	53	theme	konjac	409:414	arg1	oligosaccharides					423:438	synbiotic yogurt containing konjac mannan oligosaccharides	381:438	synbiotic yogurt containing konjac mannan oligosaccharides (KMOS)	381:445	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	6	54	theme	excitability	784:795	arg1	acetylcholine					842:854	acetylcholine	842:854	acetylcholine	842:854	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	54	theme	excitability	784:795	arg1	motilin					816:822	motilin	816:822	motilin	816:822	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	54	theme	excitability	784:795	arg1	P					835:835	substance P	825:835	substance P	825:835	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	54	theme	excitability	784:795	arg1	neurotransmitters					797:813	excitability neurotransmitters	784:813	excitability neurotransmitters (motilin, substance P, and acetylcholine)	784:855	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	8	55	dep	composition	1421:1431	arg1	the					1407:1409	the	1407:1409	the	1407:1409	Additionally, YBK2.0 treatment significantly regulated the community composition and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of gut microbiota, which were positively correlated with physiological parameters of constipation.
33663840	6	56	theme	inhibitory	954:963	arg1	peptide					1006:1012	vasoactive intestinal peptide	984:1012	vasoactive intestinal peptide	984:1012	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	56	theme	inhibitory	954:963	arg1	oxide					1022:1026	nitric oxide	1015:1026	nitric oxide	1015:1026	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	56	theme	inhibitory	954:963	arg1	acetylcholine					1033:1045	acetylcholine	1033:1045	acetylcholine	1033:1045	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	56	theme	inhibitory	954:963	arg1	neurotransmitters					965:981	inhibitory neurotransmitters	954:981	inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine)	954:1046	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	0	57	theme	Bifidobacterium	63:77	arg1	ssp					88:90	Bifidobacterium animalis ssp	63:90	Bifidobacterium animalis ssp	63:90	Synbiotic yogurt containing konjac mannan oligosaccharides and Bifidobacterium animalis ssp.
33663840	4	58	theme	constipated	503:513	arg1	mice					523:526	constipated Kunming mice	503:526	constipated Kunming mice (the model group)	503:544	lactis BB12 (BB12) on constipated Kunming mice (the model group).
33663840	4	58	theme	constipated	503:513	arg1	group					539:543	the model group	529:543	the model group	529:543	lactis BB12 (BB12) on constipated Kunming mice (the model group).
33663840	5	59	theme	fecal	628:632	arg1	weight					634:639	black fecal weight	622:639	black fecal weight	622:639	Following administration of yogurt containing 2.0% KMOS and BB12 (YBK2.0), black fecal weight and number and gastrointestinal transit rate increased by 97.5, 106.3, and 55.7%, respectively, compared with the model group.
33663840	5	60	contain	containing	582:591	arg2	KMOS					598:601	2.0% KMOS	593:601	2.0% KMOS	593:601	Following administration of yogurt containing 2.0% KMOS and BB12 (YBK2.0), black fecal weight and number and gastrointestinal transit rate increased by 97.5, 106.3, and 55.7%, respectively, compared with the model group.
33663840	5	60	contain	containing	582:591	arg2	YBK2.0					613:618	YBK2.0	613:618	YBK2.0	613:618	Following administration of yogurt containing 2.0% KMOS and BB12 (YBK2.0), black fecal weight and number and gastrointestinal transit rate increased by 97.5, 106.3, and 55.7%, respectively, compared with the model group.
33663840	5	60	contain	containing	582:591	arg1	yogurt					575:580	yogurt	575:580	yogurt containing 2.0% KMOS and BB12 (YBK2.0)	575:619	Following administration of yogurt containing 2.0% KMOS and BB12 (YBK2.0), black fecal weight and number and gastrointestinal transit rate increased by 97.5, 106.3, and 55.7%, respectively, compared with the model group.
33663840	5	60	contain	containing	582:591	arg2	BB12					607:610	BB12	607:610	BB12	607:610	Following administration of yogurt containing 2.0% KMOS and BB12 (YBK2.0), black fecal weight and number and gastrointestinal transit rate increased by 97.5, 106.3, and 55.7%, respectively, compared with the model group.
33663840	2	61	theme	dietary	222:228	arg1	supplements					230:240	Synbiotic dietary supplements	212:240	Synbiotic dietary supplements	212:240	Synbiotic dietary supplements, as an effective means of regulating the gut microbiota, may have a beneficial effect on constipation.
33663840	3	62	theme	yogurt	391:396	arg1	KMOS					441:444	KMOS	441:444	KMOS	441:444	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	3	62	theme	yogurt	391:396	arg1	oligosaccharides					423:438	synbiotic yogurt containing konjac mannan oligosaccharides	381:438	synbiotic yogurt containing konjac mannan oligosaccharides (KMOS)	381:445	This study evaluated the effects of synbiotic yogurt containing konjac mannan oligosaccharides (KMOS) and Bifidobacterium animalis ssp.
33663840	7	63	theme	peptide	1175:1181	arg1	receptor					1183:1190	vasoactive intestinal peptide receptor 1	1153:1192	vasoactive intestinal peptide receptor 1 (VIPR1)	1153:1200	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	7	63	theme	peptide	1175:1181	arg1	VIPR1					1195:1199	VIPR1	1195:1199	VIPR1	1195:1199	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	2	64	theme	Synbiotic	212:220	arg1	supplements					230:240	Synbiotic dietary supplements	212:240	Synbiotic dietary supplements	212:240	Synbiotic dietary supplements, as an effective means of regulating the gut microbiota, may have a beneficial effect on constipation.
33663840	7	65	from	expression	1222:1231	arg1	colon					1272:1276	the colon	1268:1276	the colon	1268:1276	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	1	66	from	constipation	116:127	arg1	mice					132:135	mice	132:135	mice	132:135	lactis BB12 alleviates constipation in mice by modulating the stem cell factor (SCF)/c-Kit pathway and gut microbiota.
33663840	2	67	contain	have	303:306	arg1	supplements					230:240	Synbiotic dietary supplements	212:240	Synbiotic dietary supplements	212:240	Synbiotic dietary supplements, as an effective means of regulating the gut microbiota, may have a beneficial effect on constipation.
33663840	2	67	contain	have	303:306	arg2	effect					321:326	a beneficial effect	308:326	a beneficial effect	308:326	Synbiotic dietary supplements, as an effective means of regulating the gut microbiota, may have a beneficial effect on constipation.
33663840	6	68	theme	Serum	768:772	arg1	levels					774:779	Serum levels	768:779	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group	768:875	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	2	69	theme	beneficial	310:319	arg1	effect					321:326	a beneficial effect	308:326	a beneficial effect	308:326	Synbiotic dietary supplements, as an effective means of regulating the gut microbiota, may have a beneficial effect on constipation.
33663840	7	70	theme	cell	1319:1322	arg1	SCF					1332:1334	SCF	1332:1334	SCF	1332:1334	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	7	70	theme	cell	1319:1322	arg1	factor					1324:1329	the stem cell factor	1310:1329	the stem cell factor (SCF)/c-Kit pathway	1310:1349	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	8	71	theme	YBK2.0	1366:1371	arg1	treatment					1373:1381	YBK2.0 treatment	1366:1381	YBK2.0 treatment	1366:1381	Additionally, YBK2.0 treatment significantly regulated the community composition and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of gut microbiota, which were positively correlated with physiological parameters of constipation.
33663840	2	72	theme	effective	249:257	arg1	means					259:263	an effective means	246:263	an effective means of regulating the gut microbiota	246:296	Synbiotic dietary supplements, as an effective means of regulating the gut microbiota, may have a beneficial effect on constipation.
33663840	6	73	theme	nitric	1015:1020	arg1	oxide					1022:1026	nitric oxide	1015:1026	nitric oxide	1015:1026	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	73	theme	nitric	1015:1020	arg1	neurotransmitters					965:981	inhibitory neurotransmitters	954:981	inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine)	954:1046	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	7	74	theme	serotonin	1236:1244	arg1	receptor					1246:1253	serotonin receptor 4	1236:1255	serotonin receptor 4 (5-HT4)	1236:1263	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	7	74	theme	serotonin	1236:1244	arg1	5-HT4					1258:1262	5-HT4	1258:1262	5-HT4	1258:1262	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	9	75	with	supplementation	1598:1612	arg1	yogurt					1629:1634	synbiotic yogurt	1619:1634	synbiotic yogurt composed of KMOS and BB12	1619:1660	Thus, supplementation with synbiotic yogurt composed of KMOS and BB12 could facilitate fecal excretion by regulating related pathways and the gut microbiota.
33663840	8	76	theme	constipation	1578:1589	arg1	parameters					1564:1573	physiological parameters	1550:1573	physiological parameters of constipation	1550:1589	Additionally, YBK2.0 treatment significantly regulated the community composition and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of gut microbiota, which were positively correlated with physiological parameters of constipation.
33663840	1	77	theme	stem	155:158	arg1	SCF					173:175	SCF	173:175	SCF	173:175	lactis BB12 alleviates constipation in mice by modulating the stem cell factor (SCF)/c-Kit pathway and gut microbiota.
33663840	1	77	theme	stem	155:158	arg1	factor					165:170	stem cell factor	155:170	the stem cell factor (SCF)/c-Kit pathway	151:190	lactis BB12 alleviates constipation in mice by modulating the stem cell factor (SCF)/c-Kit pathway and gut microbiota.
33663840	7	78	theme	vasoactive	1153:1162	arg1	receptor					1183:1190	vasoactive intestinal peptide receptor 1	1153:1192	vasoactive intestinal peptide receptor 1 (VIPR1)	1153:1200	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	7	78	theme	vasoactive	1153:1162	arg1	VIPR1					1195:1199	VIPR1	1195:1199	VIPR1	1195:1199	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	8	79	theme	microbiota	1500:1509	arg1	composition					1421:1431	community composition	1411:1431	community composition	1411:1431	Additionally, YBK2.0 treatment significantly regulated the community composition and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of gut microbiota, which were positively correlated with physiological parameters of constipation.
33663840	0	80	theme	animalis	79:86	arg1	ssp					88:90	Bifidobacterium animalis ssp	63:90	Bifidobacterium animalis ssp	63:90	Synbiotic yogurt containing konjac mannan oligosaccharides and Bifidobacterium animalis ssp.
33663840	6	81	dep	neurotransmitters	797:813	arg1	neurotransmitters					797:813	excitability neurotransmitters	784:813	excitability neurotransmitters (motilin, substance P, and acetylcholine)	784:855	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	81	dep	neurotransmitters	797:813	arg1	motilin					816:822	motilin	816:822	motilin	816:822	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	81	dep	neurotransmitters	797:813	arg1	P					835:835	substance P	825:835	substance P	825:835	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	6	81	dep	neurotransmitters	797:813	arg1	acetylcholine					842:854	acetylcholine	842:854	acetylcholine	842:854	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
33663840	1	82	theme	cell	160:163	arg1	SCF					173:175	SCF	173:175	SCF	173:175	lactis BB12 alleviates constipation in mice by modulating the stem cell factor (SCF)/c-Kit pathway and gut microbiota.
33663840	1	82	theme	cell	160:163	arg1	factor					165:170	stem cell factor	155:170	the stem cell factor (SCF)/c-Kit pathway	151:190	lactis BB12 alleviates constipation in mice by modulating the stem cell factor (SCF)/c-Kit pathway and gut microbiota.
33663840	7	83	theme	intestinal	1164:1173	arg1	receptor					1183:1190	vasoactive intestinal peptide receptor 1	1153:1192	vasoactive intestinal peptide receptor 1 (VIPR1)	1153:1200	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	7	83	theme	intestinal	1164:1173	arg1	VIPR1					1195:1199	VIPR1	1195:1199	VIPR1	1195:1199	Moreover, synbiotic yogurt supplementation significantly downregulated the expression of vasoactive intestinal peptide receptor 1 (VIPR1) and upregulated the expression of serotonin receptor 4 (5-HT4) in the colon, and enhanced the expression of the stem cell factor (SCF)/c-Kit pathway.
33663840	6	84	theme	YBK2.0	864:869	arg1	group					871:875	the YBK2.0 group	860:875	the YBK2.0 group	860:875	Serum levels of excitability neurotransmitters (motilin, substance P, and acetylcholine) in the YBK2.0 group were increased by 139.7, 120.4, and 91.8%, respectively, and serum levels of inhibitory neurotransmitters (vasoactive intestinal peptide, nitric oxide, and acetylcholine) were decreased.
34098538	1	0	theme	composite	191:199	arg1	scaffolds					201:209	the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds	125:209	the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents	125:236	In this study, the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents were developed by blending, cross-linking and freeze-drying, and their physicochemical properties and cell biocompatibilityin vitrowere subsequently studied.
34098538	5	1	theme	stem	969:972	arg1	cells					974:978	the bone marrow mesenchymal stem cells	941:978	the bone marrow mesenchymal stem cells	941:978	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	4	2	with	scaffold	752:759	arg1	ratio					776:780	a 5.0 wt% ratio	766:780	a 5.0 wt% ratio	766:780	In particular, the SF/nHAp/HA scaffold with a 5.0 wt% ratio exhibited the highest water absorption and mechanical properties among the developed materials.
34098538	1	3	with	scaffolds	201:209	arg1	contents					229:236	different HA contents	216:236	different HA contents	216:236	In this study, the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents were developed by blending, cross-linking and freeze-drying, and their physicochemical properties and cell biocompatibilityin vitrowere subsequently studied.
34098538	5	4	theme	bone	945:948	arg1	marrow					950:955	the bone marrow	941:955	the bone marrow mesenchymal stem cells	941:978	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	5	5	theme	marrow	950:955	arg1	cells					974:978	the bone marrow mesenchymal stem cells	941:978	the bone marrow mesenchymal stem cells	941:978	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	5	6	theme	osteogenic	1023:1032	arg1	differentiation					1034:1048	osteogenic differentiation	1023:1048	osteogenic differentiation	1023:1048	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	5	7	theme	excellent	990:998	arg1	proliferation					1005:1017	excellent cell proliferation	990:1017	excellent cell proliferation	990:1017	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	5	8	theme	differentiation	1034:1048	arg1	ability					1050:1056	excellent cell proliferation and osteogenic differentiation ability	990:1056	excellent cell proliferation and osteogenic differentiation ability	990:1056	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	2	9	theme	molecular	421:429	arg1	conformation					431:442	the molecular conformation	417:442	the molecular conformation of the composite scaffolds	417:469	It was observed that the molecular conformation of the composite scaffolds was mainly composed of silk I and a small amount of theβ-sheets structure.
34098538	1	10	theme	physicochemical	309:323	arg1	properties					325:334	their physicochemical properties	303:334	their physicochemical properties	303:334	In this study, the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents were developed by blending, cross-linking and freeze-drying, and their physicochemical properties and cell biocompatibilityin vitrowere subsequently studied.
34098538	5	11	theme	mesenchymal	957:967	arg1	cells					974:978	the bone marrow mesenchymal stem cells	941:978	the bone marrow mesenchymal stem cells	941:978	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	3	12	theme	pore	579:582	arg1	size					584:587	the pore size	575:587	the pore size of the scaffold	575:603	On enhancing the HA content, the pore size of the scaffold decreased, while the porosity, water absorption, swelling ratio and mechanical properties were observed to increase.
34098538	2	13	theme	composite	451:459	arg1	scaffolds					461:469	the composite scaffolds	447:469	the composite scaffolds	447:469	It was observed that the molecular conformation of the composite scaffolds was mainly composed of silk I and a small amount of theβ-sheets structure.
34098538	5	14	theme	thein	891:895	arg1	analysis					920:927	thein vitrocytocompatibility analysis	891:927	thein vitrocytocompatibility analysis	891:927	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	0	15	theme	silk	41:44	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and biological properties of silk fibroin/nano-hydroxyapatite/hyaluronic acid composite scaffold.
34098538	0	15	theme	silk	41:44	arg1	properties					27:36	biological properties	16:36	biological properties of silk	16:44	Preparation and biological properties of silk fibroin/nano-hydroxyapatite/hyaluronic acid composite scaffold.
34098538	6	16	theme	promising	1203:1211	arg1	class					1213:1217	a promising class	1201:1217	a promising class of materials for the bone tissue repair and regeneration	1201:1274	It can be concluded that the developed composite scaffolds represent a promising class of materials for the bone tissue repair and regeneration.
34098538	4	17	theme	highest	796:802	arg1	absorption					810:819	the highest water absorption	792:819	the highest water absorption	792:819	In particular, the SF/nHAp/HA scaffold with a 5.0 wt% ratio exhibited the highest water absorption and mechanical properties among the developed materials.
34098538	1	18	theme	different	216:224	arg1	contents					229:236	different HA contents	216:236	different HA contents	216:236	In this study, the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents were developed by blending, cross-linking and freeze-drying, and their physicochemical properties and cell biocompatibilityin vitrowere subsequently studied.
34098538	2	19	theme	small	507:511	arg1	amount					513:518	a small amount	505:518	a small amount of theβ-sheets structure	505:543	It was observed that the molecular conformation of the composite scaffolds was mainly composed of silk I and a small amount of theβ-sheets structure.
34098538	2	19	theme	small	507:511	arg1	structure					535:543	theβ-sheets structure	523:543	theβ-sheets structure	523:543	It was observed that the molecular conformation of the composite scaffolds was mainly composed of silk I and a small amount of theβ-sheets structure.
34098538	4	20	theme	wt	772:773	arg1	ratio					776:780	a 5.0 wt% ratio	766:780	a 5.0 wt% ratio	766:780	In particular, the SF/nHAp/HA scaffold with a 5.0 wt% ratio exhibited the highest water absorption and mechanical properties among the developed materials.
34098538	1	21	theme	HA	226:227	arg1	contents					229:236	different HA contents	216:236	different HA contents	216:236	In this study, the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents were developed by blending, cross-linking and freeze-drying, and their physicochemical properties and cell biocompatibilityin vitrowere subsequently studied.
34098538	5	22	theme	cell	1000:1003	arg1	proliferation					1005:1017	excellent cell proliferation	990:1017	excellent cell proliferation	990:1017	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	3	23	theme	scaffold	596:603	arg1	size					584:587	the pore size	575:587	the pore size of the scaffold	575:603	On enhancing the HA content, the pore size of the scaffold decreased, while the porosity, water absorption, swelling ratio and mechanical properties were observed to increase.
34098538	2	24	theme	silk	494:497	arg1	I					499:499	silk I	494:499	silk I	494:499	It was observed that the molecular conformation of the composite scaffolds was mainly composed of silk I and a small amount of theβ-sheets structure.
34098538	0	25	theme	biological	16:25	arg1	properties					27:36	biological properties	16:36	biological properties of silk	16:44	Preparation and biological properties of silk fibroin/nano-hydroxyapatite/hyaluronic acid composite scaffold.
34098538	1	26	theme	cell	340:343	arg1	vitrowere					364:372	cell biocompatibilityin vitrowere	340:372	cell biocompatibilityin vitrowere	340:372	In this study, the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents were developed by blending, cross-linking and freeze-drying, and their physicochemical properties and cell biocompatibilityin vitrowere subsequently studied.
34098538	4	27	theme	water	804:808	arg1	absorption					810:819	the highest water absorption	792:819	the highest water absorption	792:819	In particular, the SF/nHAp/HA scaffold with a 5.0 wt% ratio exhibited the highest water absorption and mechanical properties among the developed materials.
34098538	4	28	theme	%	774:774	arg1	ratio					776:780	a 5.0 wt% ratio	766:780	a 5.0 wt% ratio	766:780	In particular, the SF/nHAp/HA scaffold with a 5.0 wt% ratio exhibited the highest water absorption and mechanical properties among the developed materials.
34098538	5	29	theme	vitrocytocompatibility	897:918	arg1	analysis					920:927	thein vitrocytocompatibility analysis	891:927	thein vitrocytocompatibility analysis	891:927	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	2	30	theme	structure	535:543	arg1	I					499:499	silk I	494:499	silk I	494:499	It was observed that the molecular conformation of the composite scaffolds was mainly composed of silk I and a small amount of theβ-sheets structure.
34098538	2	30	theme	structure	535:543	arg1	amount					513:518	a small amount	505:518	a small amount of theβ-sheets structure	505:543	It was observed that the molecular conformation of the composite scaffolds was mainly composed of silk I and a small amount of theβ-sheets structure.
34098538	2	30	theme	structure	535:543	arg1	structure					535:543	theβ-sheets structure	523:543	theβ-sheets structure	523:543	It was observed that the molecular conformation of the composite scaffolds was mainly composed of silk I and a small amount of theβ-sheets structure.
34098538	1	31	theme	biocompatibilityin	345:362	arg1	vitrowere					364:372	cell biocompatibilityin vitrowere	340:372	cell biocompatibilityin vitrowere	340:372	In this study, the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents were developed by blending, cross-linking and freeze-drying, and their physicochemical properties and cell biocompatibilityin vitrowere subsequently studied.
34098538	5	32	theme	HA	1080:1081	arg1	scaffolds					1083:1091	the SF/nHAp/5.0 wt%HA scaffolds	1061:1091	the SF/nHAp/5.0 wt%HA scaffolds	1061:1091	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	6	33	theme	tissue	1245:1250	arg1	repair					1252:1257	the bone tissue repair	1236:1257	the bone tissue repair	1236:1257	It can be concluded that the developed composite scaffolds represent a promising class of materials for the bone tissue repair and regeneration.
34098538	2	34	theme	theβ-sheets	523:533	arg1	structure					535:543	theβ-sheets structure	523:543	theβ-sheets structure	523:543	It was observed that the molecular conformation of the composite scaffolds was mainly composed of silk I and a small amount of theβ-sheets structure.
34098538	3	35	theme	water	636:640	arg1	absorption					642:651	water absorption	636:651	water absorption	636:651	On enhancing the HA content, the pore size of the scaffold decreased, while the porosity, water absorption, swelling ratio and mechanical properties were observed to increase.
34098538	0	36	theme	acid	85:88	arg1	scaffold					100:107	acid composite scaffold	85:107	acid composite scaffold	85:107	Preparation and biological properties of silk fibroin/nano-hydroxyapatite/hyaluronic acid composite scaffold.
34098538	3	37	theme	HA	563:564	arg1	content					566:572	the HA content	559:572	the HA content	559:572	On enhancing the HA content, the pore size of the scaffold decreased, while the porosity, water absorption, swelling ratio and mechanical properties were observed to increase.
34098538	3	38	theme	mechanical	673:682	arg1	properties					684:693	mechanical properties	673:693	mechanical properties	673:693	On enhancing the HA content, the pore size of the scaffold decreased, while the porosity, water absorption, swelling ratio and mechanical properties were observed to increase.
34098538	1	39	theme	silk	129:132	arg1	scaffolds					201:209	the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds	125:209	the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents	125:236	In this study, the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents were developed by blending, cross-linking and freeze-drying, and their physicochemical properties and cell biocompatibilityin vitrowere subsequently studied.
34098538	4	40	theme	developed	857:865	arg1	materials					867:875	the developed materials	853:875	the developed materials	853:875	In particular, the SF/nHAp/HA scaffold with a 5.0 wt% ratio exhibited the highest water absorption and mechanical properties among the developed materials.
34098538	1	41	theme	fibroin/nano-hydroxyapatite/hyaluronic	134:171	arg1	scaffolds					201:209	the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds	125:209	the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents	125:236	In this study, the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents were developed by blending, cross-linking and freeze-drying, and their physicochemical properties and cell biocompatibilityin vitrowere subsequently studied.
34098538	5	42	theme	%	1079:1079	arg1	scaffolds					1083:1091	the SF/nHAp/5.0 wt%HA scaffolds	1061:1091	the SF/nHAp/5.0 wt%HA scaffolds	1061:1091	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	3	43	theme	swelling	654:661	arg1	ratio					663:667	swelling ratio	654:667	swelling ratio	654:667	On enhancing the HA content, the pore size of the scaffold decreased, while the porosity, water absorption, swelling ratio and mechanical properties were observed to increase.
34098538	1	44	theme	acid	173:176	arg1	scaffolds					201:209	the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds	125:209	the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents	125:236	In this study, the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents were developed by blending, cross-linking and freeze-drying, and their physicochemical properties and cell biocompatibilityin vitrowere subsequently studied.
34098538	5	45	theme	proliferation	1005:1017	arg1	ability					1050:1056	excellent cell proliferation and osteogenic differentiation ability	990:1056	excellent cell proliferation and osteogenic differentiation ability	990:1056	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	6	46	theme	materials	1222:1230	arg1	class					1213:1217	a promising class	1201:1217	a promising class of materials for the bone tissue repair and regeneration	1201:1274	It can be concluded that the developed composite scaffolds represent a promising class of materials for the bone tissue repair and regeneration.
34098538	6	47	theme	bone	1240:1243	arg1	repair					1252:1257	the bone tissue repair	1236:1257	the bone tissue repair	1236:1257	It can be concluded that the developed composite scaffolds represent a promising class of materials for the bone tissue repair and regeneration.
34098538	6	48	theme	developed	1161:1169	arg1	scaffolds					1181:1189	the developed composite scaffolds	1157:1189	the developed composite scaffolds	1157:1189	It can be concluded that the developed composite scaffolds represent a promising class of materials for the bone tissue repair and regeneration.
34098538	6	49	theme	composite	1171:1179	arg1	scaffolds					1181:1189	the developed composite scaffolds	1157:1189	the developed composite scaffolds	1157:1189	It can be concluded that the developed composite scaffolds represent a promising class of materials for the bone tissue repair and regeneration.
34098538	5	50	theme	other	1115:1119	arg1	scaffolds					1121:1129	the other scaffolds	1111:1129	the other scaffolds	1111:1129	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	5	51	theme	wt	1077:1078	arg1	scaffolds					1083:1091	the SF/nHAp/5.0 wt%HA scaffolds	1061:1091	the SF/nHAp/5.0 wt%HA scaffolds	1061:1091	In addition, thein vitrocytocompatibility analysis showed that the bone marrow mesenchymal stem cells exhibited excellent cell proliferation and osteogenic differentiation ability on the SF/nHAp/5.0 wt%HA scaffolds, as compared with the other scaffolds.
34098538	1	52	theme	SF/nHAp/HA	179:188	arg1	scaffolds					201:209	the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds	125:209	the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents	125:236	In this study, the silk fibroin/nano-hydroxyapatite/hyaluronic acid (SF/nHAp/HA) composite scaffolds with different HA contents were developed by blending, cross-linking and freeze-drying, and their physicochemical properties and cell biocompatibilityin vitrowere subsequently studied.
34098538	2	53	theme	scaffolds	461:469	arg1	conformation					431:442	the molecular conformation	417:442	the molecular conformation of the composite scaffolds	417:469	It was observed that the molecular conformation of the composite scaffolds was mainly composed of silk I and a small amount of theβ-sheets structure.
34098538	0	54	theme	composite	90:98	arg1	scaffold					100:107	acid composite scaffold	85:107	acid composite scaffold	85:107	Preparation and biological properties of silk fibroin/nano-hydroxyapatite/hyaluronic acid composite scaffold.
34098538	4	55	theme	mechanical	825:834	arg1	properties					836:845	mechanical properties	825:845	mechanical properties	825:845	In particular, the SF/nHAp/HA scaffold with a 5.0 wt% ratio exhibited the highest water absorption and mechanical properties among the developed materials.
34098538	4	56	theme	SF/nHAp/HA	741:750	arg1	scaffold					752:759	the SF/nHAp/HA scaffold	737:759	the SF/nHAp/HA scaffold with a 5.0 wt% ratio	737:780	In particular, the SF/nHAp/HA scaffold with a 5.0 wt% ratio exhibited the highest water absorption and mechanical properties among the developed materials.
32475599	0	0	theme	adsorbent	102:110	arg1	scalable					93:100	a scalable	91:100	a scalable adsorbent for heavy metal removal	91:134	Mechanically enhanced graphene oxide/carboxymethyl cellulose nanofibril composite fiber as a scalable adsorbent for heavy metal removal.
32475599	0	0	theme	adsorbent	102:110	arg1	fiber					82:86	composite fiber	72:86	composite fiber	72:86	Mechanically enhanced graphene oxide/carboxymethyl cellulose nanofibril composite fiber as a scalable adsorbent for heavy metal removal.
32475599	6	1	theme	GO/CMCNF-Fe3+	916:928	arg1	CF					930:931	GO/CMCNF-Fe3+ CF	916:931	GO/CMCNF-Fe3+ CF	916:931	GO/CMCNF-Fe3+ CF showed efficient lead (Pb2+) uptake with successful adsorbent recovery, which indicates durable and cost-competitive fiber type adsorbent for heavy metal ions.
32475599	1	2	theme	surface	232:238	arg1	area					240:243	its high surface area	223:243	its high surface area	223:243	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	6	3	theme	adsorbent	1061:1069	arg1	type					1056:1059	durable and cost-competitive fiber type	1021:1059	durable and cost-competitive fiber type adsorbent for heavy metal ions	1021:1090	GO/CMCNF-Fe3+ CF showed efficient lead (Pb2+) uptake with successful adsorbent recovery, which indicates durable and cost-competitive fiber type adsorbent for heavy metal ions.
32475599	2	4	theme	powder	313:318	arg1	form					320:323	powder form	313:323	powder form	313:323	However, GO itself in powder form is far away from practical adsorbents because it remains dispersed in liquid phase which causes difficulty in the separation from effluent.
32475599	0	5	theme	heavy	116:120	arg1	removal					128:134	heavy metal removal	116:134	heavy metal removal	116:134	Mechanically enhanced graphene oxide/carboxymethyl cellulose nanofibril composite fiber as a scalable adsorbent for heavy metal removal.
32475599	3	6	theme	nanofibril	507:516	arg1	adsorbent					587:595	adsorbent	587:595	adsorbent	587:595	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	3	6	theme	nanofibril	507:516	arg1	CF					542:543	CF	542:543	CF	542:543	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	3	6	theme	nanofibril	507:516	arg1	fiber					536:540	GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber	480:540	GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF)	480:544	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	6	7	theme	lead	950:953	arg1	uptake					962:967	efficient lead (Pb2+) uptake	940:967	efficient lead (Pb2+) uptake	940:967	GO/CMCNF-Fe3+ CF showed efficient lead (Pb2+) uptake with successful adsorbent recovery, which indicates durable and cost-competitive fiber type adsorbent for heavy metal ions.
32475599	5	8	theme	pure	901:904	arg1	fiber					909:913	pure GO fiber	901:913	pure GO fiber	901:913	Based on multiple interactions such as ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF, the CF exhibits enhanced mechanical property than pure GO fiber.
32475599	1	9	from	surface	282:288	arg1	groups					268:273	functional groups	257:273	functional groups on the surface	257:288	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	1	9	from	surface	282:288	arg1	area					240:243	its high surface area	223:243	its high surface area	223:243	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	1	9	from	surface	282:288	arg1	lots					249:252	lots	249:252	lots of functional groups on the surface	249:288	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	4	10	theme	wet-spinning	703:714	arg1	process					716:722	a typical wet-spinning process	693:722	a typical wet-spinning process	693:722	Cross-linked GO/CMCNF CF was continuously produced by employing Fe3+ ion as a coagulant during a typical wet-spinning process.
32475599	6	11	theme	efficient	940:948	arg1	uptake					962:967	efficient lead (Pb2+) uptake	940:967	efficient lead (Pb2+) uptake	940:967	GO/CMCNF-Fe3+ CF showed efficient lead (Pb2+) uptake with successful adsorbent recovery, which indicates durable and cost-competitive fiber type adsorbent for heavy metal ions.
32475599	1	12	from	groups	268:273	arg1	surface					282:288	the surface	278:288	the surface	278:288	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	6	13	theme	cost-competitive	1033:1048	arg1	type					1056:1059	durable and cost-competitive fiber type	1021:1059	durable and cost-competitive fiber type adsorbent for heavy metal ions	1021:1090	GO/CMCNF-Fe3+ CF showed efficient lead (Pb2+) uptake with successful adsorbent recovery, which indicates durable and cost-competitive fiber type adsorbent for heavy metal ions.
32475599	3	14	theme	GO/carboxymethyl	480:495	arg1	adsorbent					587:595	adsorbent	587:595	adsorbent	587:595	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	3	14	theme	GO/carboxymethyl	480:495	arg1	CF					542:543	CF	542:543	CF	542:543	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	3	14	theme	GO/carboxymethyl	480:495	arg1	fiber					536:540	GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber	480:540	GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF)	480:544	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	6	15	theme	durable	1021:1027	arg1	type					1056:1059	durable and cost-competitive fiber type	1021:1059	durable and cost-competitive fiber type adsorbent for heavy metal ions	1021:1090	GO/CMCNF-Fe3+ CF showed efficient lead (Pb2+) uptake with successful adsorbent recovery, which indicates durable and cost-competitive fiber type adsorbent for heavy metal ions.
32475599	4	16	theme	GO/CMCNF	611:618	arg1	CF					620:621	Cross-linked GO/CMCNF CF	598:621	Cross-linked GO/CMCNF CF	598:621	Cross-linked GO/CMCNF CF was continuously produced by employing Fe3+ ion as a coagulant during a typical wet-spinning process.
32475599	0	17	theme	metal	122:126	arg1	removal					128:134	heavy metal removal	116:134	heavy metal removal	116:134	Mechanically enhanced graphene oxide/carboxymethyl cellulose nanofibril composite fiber as a scalable adsorbent for heavy metal removal.
32475599	6	18	theme	Pb2+	956:959	arg1	uptake					962:967	efficient lead (Pb2+) uptake	940:967	efficient lead (Pb2+) uptake	940:967	GO/CMCNF-Fe3+ CF showed efficient lead (Pb2+) uptake with successful adsorbent recovery, which indicates durable and cost-competitive fiber type adsorbent for heavy metal ions.
32475599	3	19	theme	cellulose	497:505	arg1	adsorbent					587:595	adsorbent	587:595	adsorbent	587:595	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	3	19	theme	cellulose	497:505	arg1	CF					542:543	CF	542:543	CF	542:543	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	3	19	theme	cellulose	497:505	arg1	fiber					536:540	GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber	480:540	GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF)	480:544	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	6	20	theme	fiber	1050:1054	arg1	type					1056:1059	durable and cost-competitive fiber type	1021:1059	durable and cost-competitive fiber type adsorbent for heavy metal ions	1021:1090	GO/CMCNF-Fe3+ CF showed efficient lead (Pb2+) uptake with successful adsorbent recovery, which indicates durable and cost-competitive fiber type adsorbent for heavy metal ions.
32475599	2	21	theme	practical	342:350	arg1	adsorbents					352:361	practical adsorbents	342:361	practical adsorbents	342:361	However, GO itself in powder form is far away from practical adsorbents because it remains dispersed in liquid phase which causes difficulty in the separation from effluent.
32475599	0	22	theme	enhanced	13:20	arg1	cellulose					51:59	Mechanically enhanced graphene oxide/carboxymethyl cellulose	0:59	Mechanically enhanced graphene oxide/carboxymethyl cellulose	0:59	Mechanically enhanced graphene oxide/carboxymethyl cellulose nanofibril composite fiber as a scalable adsorbent for heavy metal removal.
32475599	3	23	theme	composite	526:534	arg1	adsorbent					587:595	adsorbent	587:595	adsorbent	587:595	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	3	23	theme	composite	526:534	arg1	CF					542:543	CF	542:543	CF	542:543	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	3	23	theme	composite	526:534	arg1	fiber					536:540	GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber	480:540	GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF)	480:544	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	1	24	theme	much	177:180	arg1	attention					182:190	much attention	177:190	much attention	177:190	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	5	25	theme	ionic	764:768	arg1	interactions					796:807	ionic bonding and electrostatic interactions	764:807	ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF	764:848	Based on multiple interactions such as ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF, the CF exhibits enhanced mechanical property than pure GO fiber.
32475599	5	26	theme	carboxyl	826:833	arg1	group					835:839	carboxyl group	826:839	carboxyl group	826:839	Based on multiple interactions such as ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF, the CF exhibits enhanced mechanical property than pure GO fiber.
32475599	0	27	theme	oxide/carboxymethyl	31:49	arg1	cellulose					51:59	Mechanically enhanced graphene oxide/carboxymethyl cellulose	0:59	Mechanically enhanced graphene oxide/carboxymethyl cellulose	0:59	Mechanically enhanced graphene oxide/carboxymethyl cellulose nanofibril composite fiber as a scalable adsorbent for heavy metal removal.
32475599	1	28	theme	functional	257:266	arg1	groups					268:273	functional groups	257:273	functional groups on the surface	257:288	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	1	29	dep	oxide	156:160	arg1	GO					162:163	GO	162:163	GO	162:163	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	5	30	theme	electrostatic	782:794	arg1	interactions					796:807	ionic bonding and electrostatic interactions	764:807	ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF	764:848	Based on multiple interactions such as ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF, the CF exhibits enhanced mechanical property than pure GO fiber.
32475599	0	31	theme	graphene	22:29	arg1	cellulose					51:59	Mechanically enhanced graphene oxide/carboxymethyl cellulose	0:59	Mechanically enhanced graphene oxide/carboxymethyl cellulose	0:59	Mechanically enhanced graphene oxide/carboxymethyl cellulose nanofibril composite fiber as a scalable adsorbent for heavy metal removal.
32475599	1	32	theme	groups	268:273	arg1	groups					268:273	functional groups	257:273	functional groups on the surface	257:288	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	1	32	theme	groups	268:273	arg1	area					240:243	its high surface area	223:243	its high surface area	223:243	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	1	32	theme	groups	268:273	arg1	lots					249:252	lots	249:252	lots of functional groups on the surface	249:288	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	1	33	from	lots	249:252	arg1	surface					282:288	the surface	278:288	the surface	278:288	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	2	34	dep	itself	303:308	arg1	GO					300:301	GO	300:301	GO	300:301	However, GO itself in powder form is far away from practical adsorbents because it remains dispersed in liquid phase which causes difficulty in the separation from effluent.
32475599	1	35	theme	heavy	196:200	arg1	removal					208:214	heavy metal removal	196:214	heavy metal removal due to its high surface area and lots of functional groups on the surface	196:288	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	5	36	theme	enhanced	867:874	arg1	property					887:894	enhanced mechanical property	867:894	enhanced mechanical property than pure GO fiber	867:913	Based on multiple interactions such as ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF, the CF exhibits enhanced mechanical property than pure GO fiber.
32475599	1	37	theme	metal	202:206	arg1	removal					208:214	heavy metal removal	196:214	heavy metal removal due to its high surface area and lots of functional groups on the surface	196:288	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	5	38	theme	multiple	734:741	arg1	interactions					743:754	multiple interactions	734:754	multiple interactions such as ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF	734:848	Based on multiple interactions such as ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF, the CF exhibits enhanced mechanical property than pure GO fiber.
32475599	5	38	theme	multiple	734:741	arg1	interactions					796:807	ionic bonding and electrostatic interactions	764:807	ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF	764:848	Based on multiple interactions such as ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF, the CF exhibits enhanced mechanical property than pure GO fiber.
32475599	1	39	from	area	240:243	arg1	surface					282:288	the surface	278:288	the surface	278:288	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	2	40	theme	liquid	395:400	arg1	phase					402:406	liquid phase	395:406	liquid phase which causes difficulty in the separation from effluent	395:462	However, GO itself in powder form is far away from practical adsorbents because it remains dispersed in liquid phase which causes difficulty in the separation from effluent.
32475599	4	41	theme	typical	695:701	arg1	process					716:722	a typical wet-spinning process	693:722	a typical wet-spinning process	693:722	Cross-linked GO/CMCNF CF was continuously produced by employing Fe3+ ion as a coagulant during a typical wet-spinning process.
32475599	2	42	from	effluent	455:462	arg1	separation					439:448	the separation	435:448	the separation from effluent	435:462	However, GO itself in powder form is far away from practical adsorbents because it remains dispersed in liquid phase which causes difficulty in the separation from effluent.
32475599	5	43	theme	bonding	770:776	arg1	interactions					796:807	ionic bonding and electrostatic interactions	764:807	ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF	764:848	Based on multiple interactions such as ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF, the CF exhibits enhanced mechanical property than pure GO fiber.
32475599	0	44	theme	composite	72:80	arg1	scalable					93:100	a scalable	91:100	a scalable adsorbent for heavy metal removal	91:134	Mechanically enhanced graphene oxide/carboxymethyl cellulose nanofibril composite fiber as a scalable adsorbent for heavy metal removal.
32475599	0	44	theme	composite	72:80	arg1	fiber					82:86	composite fiber	72:86	composite fiber	72:86	Mechanically enhanced graphene oxide/carboxymethyl cellulose nanofibril composite fiber as a scalable adsorbent for heavy metal removal.
32475599	4	45	link	Cross-linked	598:609	arg1	CF					620:621	Cross-linked GO/CMCNF CF	598:621	Cross-linked GO/CMCNF CF	598:621	Cross-linked GO/CMCNF CF was continuously produced by employing Fe3+ ion as a coagulant during a typical wet-spinning process.
32475599	4	46	theme	Fe3+	662:665	arg1	ion					667:669	Fe3+ ion	662:669	Fe3+ ion	662:669	Cross-linked GO/CMCNF CF was continuously produced by employing Fe3+ ion as a coagulant during a typical wet-spinning process.
32475599	4	46	theme	Fe3+	662:665	arg1	coagulant					676:684	a coagulant	674:684	a coagulant during a typical wet-spinning process	674:722	Cross-linked GO/CMCNF CF was continuously produced by employing Fe3+ ion as a coagulant during a typical wet-spinning process.
32475599	5	47	from	interactions	796:807	arg1	CMCNF					844:848	CMCNF	844:848	CMCNF	844:848	Based on multiple interactions such as ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF, the CF exhibits enhanced mechanical property than pure GO fiber.
32475599	5	48	theme	mechanical	876:885	arg1	property					887:894	enhanced mechanical property	867:894	enhanced mechanical property than pure GO fiber	867:913	Based on multiple interactions such as ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF, the CF exhibits enhanced mechanical property than pure GO fiber.
32475599	3	49	theme	CMCNF	519:523	arg1	adsorbent					587:595	adsorbent	587:595	adsorbent	587:595	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	3	49	theme	CMCNF	519:523	arg1	CF					542:543	CF	542:543	CF	542:543	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	3	49	theme	CMCNF	519:523	arg1	fiber					536:540	GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber	480:540	GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF)	480:544	In this study, GO/carboxymethyl cellulose nanofibril (CMCNF) composite fiber(CF) is developed as an efficient and durable adsorbent.
32475599	6	50	theme	successful	974:983	arg1	recovery					995:1002	successful adsorbent recovery	974:1002	successful adsorbent recovery	974:1002	GO/CMCNF-Fe3+ CF showed efficient lead (Pb2+) uptake with successful adsorbent recovery, which indicates durable and cost-competitive fiber type adsorbent for heavy metal ions.
32475599	1	51	theme	graphene	147:154	arg1	oxide					156:160	graphene oxide	147:160	graphene oxide(GO)	147:164	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
32475599	6	52	theme	metal	1081:1085	arg1	ions					1087:1090	heavy metal ions	1075:1090	heavy metal ions	1075:1090	GO/CMCNF-Fe3+ CF showed efficient lead (Pb2+) uptake with successful adsorbent recovery, which indicates durable and cost-competitive fiber type adsorbent for heavy metal ions.
32475599	6	53	theme	adsorbent	985:993	arg1	recovery					995:1002	successful adsorbent recovery	974:1002	successful adsorbent recovery	974:1002	GO/CMCNF-Fe3+ CF showed efficient lead (Pb2+) uptake with successful adsorbent recovery, which indicates durable and cost-competitive fiber type adsorbent for heavy metal ions.
32475599	4	54	theme	Cross-linked	598:609	arg1	CF					620:621	Cross-linked GO/CMCNF CF	598:621	Cross-linked GO/CMCNF CF	598:621	Cross-linked GO/CMCNF CF was continuously produced by employing Fe3+ ion as a coagulant during a typical wet-spinning process.
32475599	6	55	theme	heavy	1075:1079	arg1	ions					1087:1090	heavy metal ions	1075:1090	heavy metal ions	1075:1090	GO/CMCNF-Fe3+ CF showed efficient lead (Pb2+) uptake with successful adsorbent recovery, which indicates durable and cost-competitive fiber type adsorbent for heavy metal ions.
32475599	5	56	dep	fiber	909:913	arg1	GO					906:907	GO	906:907	GO	906:907	Based on multiple interactions such as ionic bonding and electrostatic interactions between Fe3+ and carboxyl group on CMCNF, the CF exhibits enhanced mechanical property than pure GO fiber.
32475599	1	57	theme	high	227:230	arg1	area					240:243	its high surface area	223:243	its high surface area	223:243	Recently, graphene oxide(GO) has gained much attention for heavy metal removal due to its high surface area and lots of functional groups on the surface.
31880915	4	0	theme	liver	984:988	arg1	model					997:1001	a rat liver injury model	978:1001	a rat liver injury model	978:1001	This study is the first to evaluate the performance of OBC, OBC/CS, and the OBC/COL/CS composite for rapid internal hemostasis using a rat liver injury model.
31880915	8	1	theme	Surgicel	1676:1683	arg1	gauze					1685:1689	the commercial hemostatic ORC product Surgicel gauze	1638:1689	the commercial hemostatic ORC product Surgicel gauze	1638:1689	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	5	2	theme	commercial	1113:1122	arg1	ORC					1173:1175	ORC	1173:1175	ORC	1173:1175	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	5	2	theme	commercial	1113:1122	arg1	cellulose					1162:1170	commercial hemostatic oxidized regenerated plant cellulose	1113:1170	commercial hemostatic oxidized regenerated plant cellulose (ORC)	1113:1176	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	6	3	dep	nanocomposite	1194:1206	arg1	exhibited					1208:1216	exhibited	1208:1216	nanocomposite exhibited appropriate mechanical strength, broad spectrum antimicrobial properties, and excellent biodegradation in vivo	1194:1327	The OBC/COL/CS nanocomposite exhibited appropriate mechanical strength, broad spectrum antimicrobial properties, and excellent biodegradation in vivo.
31880915	3	4	theme	collagen	683:690	arg1	introduction					667:678	The introduction	663:678	The introduction of collagen	663:690	The introduction of collagen was anticipated to provide functional properties such as enhanced hemostasis and promotion of wound healing so as to achieve a new functional composite.
31880915	5	5	theme	oxidized	1135:1142	arg1	ORC					1173:1175	ORC	1173:1175	ORC	1173:1175	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	5	5	theme	oxidized	1135:1142	arg1	cellulose					1162:1170	commercial hemostatic oxidized regenerated plant cellulose	1113:1170	commercial hemostatic oxidized regenerated plant cellulose (ORC)	1113:1176	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	1	6	theme	high	203:206	arg1	absorption					214:223	high blood absorption	203:223	high blood absorption	203:223	The development of biodegradable and antibacterial hemostatic materials with high blood absorption to halt the internal hemorrhage of deep noncompressible wounds remains a challenge.
31880915	2	7	theme	novel	326:330	arg1	OBC/COL/CS					358:367	OBC/COL/CS	358:367	OBC/COL/CS	358:367	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	2	7	theme	novel	326:330	arg1	nanocomposite					343:355	a novel hemostatic nanocomposite	324:355	a novel hemostatic nanocomposite (OBC/COL/CS)	324:368	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	7	8	theme	excellent	1343:1351	arg1	efficacy					1364:1371	excellent hemostatic efficacy	1343:1371	excellent hemostatic efficacy of the composite	1343:1388	Furthermore, excellent hemostatic efficacy of the composite was confirmed in vivo.
31880915	2	9	theme	OBC	522:524	arg1	component					589:597	a functional component	576:597	a functional component by the electrostatic attraction of cationic CS and anionic OBC	576:660	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	2	9	theme	OBC	522:524	arg1	self-assembly					505:517	the electrostatic self-assembly	487:517	the electrostatic self-assembly of OBC with CS (OBC/CS), COL	487:546	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	1	10	theme	internal	237:244	arg1	hemorrhage					246:255	the internal hemorrhage	233:255	the internal hemorrhage of deep noncompressible wounds	233:286	The development of biodegradable and antibacterial hemostatic materials with high blood absorption to halt the internal hemorrhage of deep noncompressible wounds remains a challenge.
31880915	8	11	dep	concomitant	1548:1558	arg1	lower					1560:1564	lower	1560:1564	lower	1560:1564	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	2	12	theme	anionic	650:656	arg1	OBC					658:660	anionic OBC	650:660	anionic OBC	650:660	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	6	13	theme	mechanical	1230:1239	arg1	strength					1241:1248	appropriate mechanical strength	1218:1248	appropriate mechanical strength	1218:1248	The OBC/COL/CS nanocomposite exhibited appropriate mechanical strength, broad spectrum antimicrobial properties, and excellent biodegradation in vivo.
31880915	1	14	theme	biodegradable	145:157	arg1	materials					188:196	biodegradable and antibacterial hemostatic materials	145:196	biodegradable and antibacterial hemostatic materials with high blood absorption	145:223	The development of biodegradable and antibacterial hemostatic materials with high blood absorption to halt the internal hemorrhage of deep noncompressible wounds remains a challenge.
31880915	8	15	theme	procoagulant	1442:1453	arg1	adhesion					1504:1511	higher adhesion	1497:1511	higher adhesion of erythrocytes and platelets	1497:1541	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	8	15	theme	procoagulant	1442:1453	arg1	properties					1455:1464	greater procoagulant properties	1434:1464	greater procoagulant properties	1434:1464	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	5	16	theme	first	1039:1043	arg1	study					1045:1049	the first study	1035:1049	the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC)	1035:1176	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	5	16	theme	first	1039:1043	arg1	this					1022:1025	this	1022:1025	this	1022:1025	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	1	17	theme	antibacterial	163:175	arg1	materials					188:196	biodegradable and antibacterial hemostatic materials	145:196	biodegradable and antibacterial hemostatic materials with high blood absorption	145:223	The development of biodegradable and antibacterial hemostatic materials with high blood absorption to halt the internal hemorrhage of deep noncompressible wounds remains a challenge.
31880915	4	18	theme	OBC/COL/CS	921:930	arg1	performance					885:895	the performance	881:895	the performance of OBC, OBC/CS, and the OBC/COL/CS composite for rapid internal hemostasis using a rat liver injury model	881:1001	This study is the first to evaluate the performance of OBC, OBC/CS, and the OBC/COL/CS composite for rapid internal hemostasis using a rat liver injury model.
31880915	0	19	theme	Rapid	90:94	arg1	Hemostasis					96:105	Rapid Hemostasis	90:105	Rapid Hemostasis	90:105	A Biodegradable Antibacterial Nanocomposite Based on Oxidized Bacterial Nanocellulose for Rapid Hemostasis and Wound Healing.
31880915	1	20	with	materials	188:196	arg1	absorption					214:223	high blood absorption	203:223	high blood absorption	203:223	The development of biodegradable and antibacterial hemostatic materials with high blood absorption to halt the internal hemorrhage of deep noncompressible wounds remains a challenge.
31880915	1	21	theme	materials	188:196	arg1	development					130:140	The development	126:140	The development of biodegradable and antibacterial hemostatic materials with high blood absorption to halt the internal hemorrhage of deep noncompressible wounds	126:286	The development of biodegradable and antibacterial hemostatic materials with high blood absorption to halt the internal hemorrhage of deep noncompressible wounds remains a challenge.
31880915	3	22	theme	functional	823:832	arg1	composite					834:842	a new functional composite	817:842	a new functional composite	817:842	The introduction of collagen was anticipated to provide functional properties such as enhanced hemostasis and promotion of wound healing so as to achieve a new functional composite.
31880915	9	23	theme	efficient	1746:1754	arg1	agent					1769:1773	a fast and efficient procoagulant agent	1735:1773	a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding	1735:1895	The results suggest that the OBC/COL/CS is a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding.
31880915	9	23	theme	efficient	1746:1754	arg1	OBC/COL/CS					1721:1730	the OBC/COL/CS	1717:1730	the OBC/COL/CS	1717:1730	The results suggest that the OBC/COL/CS is a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding.
31880915	2	24	theme	electrostatic	606:618	arg1	attraction					620:629	the electrostatic attraction	602:629	the electrostatic attraction of cationic CS and anionic OBC	602:660	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	3	25	theme	wound	786:790	arg1	healing					792:798	wound healing	786:798	wound healing	786:798	The introduction of collagen was anticipated to provide functional properties such as enhanced hemostasis and promotion of wound healing so as to achieve a new functional composite.
31880915	4	26	theme	OBC/CS	905:910	arg1	performance					885:895	the performance	881:895	the performance of OBC, OBC/CS, and the OBC/COL/CS composite for rapid internal hemostasis using a rat liver injury model	881:1001	This study is the first to evaluate the performance of OBC, OBC/CS, and the OBC/COL/CS composite for rapid internal hemostasis using a rat liver injury model.
31880915	8	27	theme	higher	1497:1502	arg1	adhesion					1504:1511	higher adhesion	1497:1511	higher adhesion of erythrocytes and platelets	1497:1541	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	8	27	theme	higher	1497:1502	arg1	properties					1455:1464	greater procoagulant properties	1434:1464	greater procoagulant properties	1434:1464	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	9	28	theme	good	1780:1783	arg1	properties					1799:1808	good antibacterial properties	1780:1808	good antibacterial properties	1780:1808	The results suggest that the OBC/COL/CS is a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding.
31880915	2	29	theme	CS	643:644	arg1	attraction					620:629	the electrostatic attraction	602:629	the electrostatic attraction of cationic CS and anionic OBC	602:660	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	2	30	theme	bacterial	406:414	arg1	cellulose					416:424	bacterial cellulose	406:424	bacterial cellulose (OBC)	406:430	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	2	30	theme	bacterial	406:414	arg1	OBC					427:429	OBC	427:429	OBC	427:429	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	5	31	theme	faster	1076:1081	arg1	biodegradability					1083:1098	a faster biodegradability	1074:1098	a faster biodegradability	1074:1098	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	2	32	with	self-assembly	505:517	arg1	OBC/CS					535:540	OBC/CS	535:540	OBC/CS	535:540	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	2	32	with	self-assembly	505:517	arg1	COL					544:546	COL	544:546	COL	544:546	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	2	32	with	self-assembly	505:517	arg1	CS					531:532	CS	531:532	CS (OBC/CS)	531:541	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	4	33	theme	rat	980:982	arg1	model					997:1001	a rat liver injury model	978:1001	a rat liver injury model	978:1001	This study is the first to evaluate the performance of OBC, OBC/CS, and the OBC/COL/CS composite for rapid internal hemostasis using a rat liver injury model.
31880915	0	34	theme	Antibacterial	16:28	arg1	Nanocomposite					30:42	A Biodegradable Antibacterial Nanocomposite	0:42	A Biodegradable Antibacterial Nanocomposite	0:42	A Biodegradable Antibacterial Nanocomposite Based on Oxidized Bacterial Nanocellulose for Rapid Hemostasis and Wound Healing.
31880915	9	35	theme	great	1814:1818	arg1	potential					1820:1828	great potential	1814:1828	great potential	1814:1828	The results suggest that the OBC/COL/CS is a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding.
31880915	4	36	theme	internal	952:959	arg1	hemostasis					961:970	rapid internal hemostasis	946:970	rapid internal hemostasis using a rat liver injury model	946:1001	This study is the first to evaluate the performance of OBC, OBC/CS, and the OBC/COL/CS composite for rapid internal hemostasis using a rat liver injury model.
31880915	0	37	theme	Oxidized	53:60	arg1	Nanocellulose					72:84	Oxidized Bacterial Nanocellulose	53:84	Oxidized Bacterial Nanocellulose for Rapid Hemostasis and Wound Healing	53:123	A Biodegradable Antibacterial Nanocomposite Based on Oxidized Bacterial Nanocellulose for Rapid Hemostasis and Wound Healing.
31880915	5	38	theme	regenerated	1144:1154	arg1	ORC					1173:1175	ORC	1173:1175	ORC	1173:1175	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	5	38	theme	regenerated	1144:1154	arg1	cellulose					1162:1170	commercial hemostatic oxidized regenerated plant cellulose	1113:1170	commercial hemostatic oxidized regenerated plant cellulose (ORC)	1113:1176	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	9	39	theme	absorbable	1844:1853	arg1	hemostat					1855:1862	an absorbable hemostat	1841:1862	an absorbable hemostat for control of internal bleeding	1841:1895	The results suggest that the OBC/COL/CS is a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding.
31880915	1	40	theme	deep	260:263	arg1	wounds					281:286	deep noncompressible wounds	260:286	deep noncompressible wounds	260:286	The development of biodegradable and antibacterial hemostatic materials with high blood absorption to halt the internal hemorrhage of deep noncompressible wounds remains a challenge.
31880915	4	41	theme	injury	990:995	arg1	model					997:1001	a rat liver injury model	978:1001	a rat liver injury model	978:1001	This study is the first to evaluate the performance of OBC, OBC/CS, and the OBC/COL/CS composite for rapid internal hemostasis using a rat liver injury model.
31880915	9	42	theme	fast	1737:1740	arg1	agent					1769:1773	a fast and efficient procoagulant agent	1735:1773	a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding	1735:1895	The results suggest that the OBC/COL/CS is a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding.
31880915	9	42	theme	fast	1737:1740	arg1	OBC/COL/CS					1721:1730	the OBC/COL/CS	1717:1730	the OBC/COL/CS	1717:1730	The results suggest that the OBC/COL/CS is a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding.
31880915	6	43	theme	appropriate	1218:1228	arg1	strength					1241:1248	appropriate mechanical strength	1218:1248	appropriate mechanical strength	1218:1248	The OBC/COL/CS nanocomposite exhibited appropriate mechanical strength, broad spectrum antimicrobial properties, and excellent biodegradation in vivo.
31880915	8	44	theme	hemostatic	1653:1662	arg1	gauze					1685:1689	the commercial hemostatic ORC product Surgicel gauze	1638:1689	the commercial hemostatic ORC product Surgicel gauze	1638:1689	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	1	45	theme	wounds	281:286	arg1	hemorrhage					246:255	the internal hemorrhage	233:255	the internal hemorrhage of deep noncompressible wounds	233:286	The development of biodegradable and antibacterial hemostatic materials with high blood absorption to halt the internal hemorrhage of deep noncompressible wounds remains a challenge.
31880915	8	46	theme	product	1668:1674	arg1	gauze					1685:1689	the commercial hemostatic ORC product Surgicel gauze	1638:1689	the commercial hemostatic ORC product Surgicel gauze	1638:1689	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	5	47	theme	hemostatic	1124:1133	arg1	ORC					1173:1175	ORC	1173:1175	ORC	1173:1175	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	5	47	theme	hemostatic	1124:1133	arg1	cellulose					1162:1170	commercial hemostatic oxidized regenerated plant cellulose	1113:1170	commercial hemostatic oxidized regenerated plant cellulose (ORC)	1113:1176	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	9	48	theme	bleeding	1888:1895	arg1	control					1868:1874	control	1868:1874	control of internal bleeding	1868:1895	The results suggest that the OBC/COL/CS is a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding.
31880915	8	49	theme	bleeding	1616:1623	arg1	cessation					1603:1611	ultrafast cessation	1593:1611	ultrafast cessation of bleeding	1593:1623	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	2	50	theme	functional	578:587	arg1	self-assembly					505:517	the electrostatic self-assembly	487:517	the electrostatic self-assembly of OBC with CS (OBC/CS), COL	487:546	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	2	50	theme	functional	578:587	arg1	component					589:597	a functional component	576:597	a functional component by the electrostatic attraction of cationic CS and anionic OBC	576:660	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	7	51	theme	composite	1380:1388	arg1	efficacy					1364:1371	excellent hemostatic efficacy	1343:1371	excellent hemostatic efficacy of the composite	1343:1388	Furthermore, excellent hemostatic efficacy of the composite was confirmed in vivo.
31880915	2	52	theme	hemostatic	332:341	arg1	OBC/COL/CS					358:367	OBC/COL/CS	358:367	OBC/COL/CS	358:367	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	2	52	theme	hemostatic	332:341	arg1	nanocomposite					343:355	a novel hemostatic nanocomposite	324:355	a novel hemostatic nanocomposite (OBC/COL/CS)	324:368	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	1	53	theme	blood	208:212	arg1	absorption					214:223	high blood absorption	203:223	high blood absorption	203:223	The development of biodegradable and antibacterial hemostatic materials with high blood absorption to halt the internal hemorrhage of deep noncompressible wounds remains a challenge.
31880915	3	54	theme	functional	719:728	arg1	promotion					773:781	promotion	773:781	promotion of wound healing	773:798	The introduction of collagen was anticipated to provide functional properties such as enhanced hemostasis and promotion of wound healing so as to achieve a new functional composite.
31880915	3	54	theme	functional	719:728	arg1	hemostasis					758:767	enhanced hemostasis	749:767	enhanced hemostasis	749:767	The introduction of collagen was anticipated to provide functional properties such as enhanced hemostasis and promotion of wound healing so as to achieve a new functional composite.
31880915	3	54	theme	functional	719:728	arg1	properties					730:739	functional properties	719:739	functional properties such as enhanced hemostasis and promotion of wound healing so as to achieve a new functional composite	719:842	The introduction of collagen was anticipated to provide functional properties such as enhanced hemostasis and promotion of wound healing so as to achieve a new functional composite.
31880915	7	55	theme	hemostatic	1353:1362	arg1	efficacy					1364:1371	excellent hemostatic efficacy	1343:1371	excellent hemostatic efficacy of the composite	1343:1388	Furthermore, excellent hemostatic efficacy of the composite was confirmed in vivo.
31880915	6	56	theme	antimicrobial	1266:1278	arg1	properties					1280:1289	broad spectrum antimicrobial properties	1251:1289	broad spectrum antimicrobial properties	1251:1289	The OBC/COL/CS nanocomposite exhibited appropriate mechanical strength, broad spectrum antimicrobial properties, and excellent biodegradation in vivo.
31880915	9	57	with	agent	1769:1773	arg1	properties					1799:1808	good antibacterial properties	1780:1808	good antibacterial properties	1780:1808	The results suggest that the OBC/COL/CS is a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding.
31880915	9	57	with	agent	1769:1773	arg1	potential					1820:1828	great potential	1814:1828	great potential	1814:1828	The results suggest that the OBC/COL/CS is a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding.
31880915	3	58	theme	enhanced	749:756	arg1	hemostasis					758:767	enhanced hemostasis	749:767	enhanced hemostasis	749:767	The introduction of collagen was anticipated to provide functional properties such as enhanced hemostasis and promotion of wound healing so as to achieve a new functional composite.
31880915	6	59	theme	broad	1251:1255	arg1	spectrum					1257:1264	broad spectrum	1251:1264	broad spectrum	1251:1264	The OBC/COL/CS nanocomposite exhibited appropriate mechanical strength, broad spectrum antimicrobial properties, and excellent biodegradation in vivo.
31880915	5	60	contain	has	1070:1072	arg2	biodegradability					1083:1098	a faster biodegradability	1074:1098	a faster biodegradability	1074:1098	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	5	60	contain	has	1070:1072	arg1	OBC					1066:1068	OBC	1066:1068	OBC	1066:1068	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	8	61	theme	greater	1434:1440	arg1	adhesion					1504:1511	higher adhesion	1497:1511	higher adhesion of erythrocytes and platelets	1497:1541	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	8	61	theme	greater	1434:1440	arg1	properties					1455:1464	greater procoagulant properties	1434:1464	greater procoagulant properties	1434:1464	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	2	62	theme	OBC	658:660	arg1	attraction					620:629	the electrostatic attraction	602:629	the electrostatic attraction of cationic CS and anionic OBC	602:660	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	3	63	theme	new	819:821	arg1	composite					834:842	a new functional composite	817:842	a new functional composite	817:842	The introduction of collagen was anticipated to provide functional properties such as enhanced hemostasis and promotion of wound healing so as to achieve a new functional composite.
31880915	8	64	theme	blood-clotting	1470:1483	arg1	capability					1485:1494	blood-clotting capability	1470:1494	blood-clotting capability	1470:1494	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	9	65	theme	procoagulant	1756:1767	arg1	agent					1769:1773	a fast and efficient procoagulant agent	1735:1773	a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding	1735:1895	The results suggest that the OBC/COL/CS is a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding.
31880915	9	65	theme	procoagulant	1756:1767	arg1	OBC/COL/CS					1721:1730	the OBC/COL/CS	1717:1730	the OBC/COL/CS	1717:1730	The results suggest that the OBC/COL/CS is a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding.
31880915	1	66	theme	hemostatic	177:186	arg1	materials					188:196	biodegradable and antibacterial hemostatic materials	145:196	biodegradable and antibacterial hemostatic materials with high blood absorption	145:223	The development of biodegradable and antibacterial hemostatic materials with high blood absorption to halt the internal hemorrhage of deep noncompressible wounds remains a challenge.
31880915	0	67	theme	Wound	111:115	arg1	Healing					117:123	Wound Healing	111:123	Wound Healing	111:123	A Biodegradable Antibacterial Nanocomposite Based on Oxidized Bacterial Nanocellulose for Rapid Hemostasis and Wound Healing.
31880915	8	68	dep	cessation	1603:1611	arg1	addition					1581:1588	addition	1581:1588	addition	1581:1588	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	2	69	theme	electrostatic	491:503	arg1	component					589:597	a functional component	576:597	a functional component by the electrostatic attraction of cationic CS and anionic OBC	576:660	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	2	69	theme	electrostatic	491:503	arg1	self-assembly					505:517	the electrostatic self-assembly	487:517	the electrostatic self-assembly of OBC with CS (OBC/CS), COL	487:546	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	3	70	theme	healing	792:798	arg1	promotion					773:781	promotion	773:781	promotion of wound healing	773:798	The introduction of collagen was anticipated to provide functional properties such as enhanced hemostasis and promotion of wound healing so as to achieve a new functional composite.
31880915	3	70	theme	healing	792:798	arg1	hemostasis					758:767	enhanced hemostasis	749:767	enhanced hemostasis	749:767	The introduction of collagen was anticipated to provide functional properties such as enhanced hemostasis and promotion of wound healing so as to achieve a new functional composite.
31880915	6	71	theme	excellent	1296:1304	arg1	biodegradation					1306:1319	excellent biodegradation	1296:1319	excellent biodegradation	1296:1319	The OBC/COL/CS nanocomposite exhibited appropriate mechanical strength, broad spectrum antimicrobial properties, and excellent biodegradation in vivo.
31880915	8	72	theme	erythrocytes	1516:1527	arg1	adhesion					1504:1511	higher adhesion	1497:1511	higher adhesion of erythrocytes and platelets	1497:1541	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	8	72	theme	erythrocytes	1516:1527	arg1	properties					1455:1464	greater procoagulant properties	1434:1464	greater procoagulant properties	1434:1464	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	0	73	theme	Biodegradable	2:14	arg1	Nanocomposite					30:42	A Biodegradable Antibacterial Nanocomposite	0:42	A Biodegradable Antibacterial Nanocomposite	0:42	A Biodegradable Antibacterial Nanocomposite Based on Oxidized Bacterial Nanocellulose for Rapid Hemostasis and Wound Healing.
31880915	4	74	theme	OBC	900:902	arg1	performance					885:895	the performance	881:895	the performance of OBC, OBC/CS, and the OBC/COL/CS composite for rapid internal hemostasis using a rat liver injury model	881:1001	This study is the first to evaluate the performance of OBC, OBC/CS, and the OBC/COL/CS composite for rapid internal hemostasis using a rat liver injury model.
31880915	9	75	theme	antibacterial	1785:1797	arg1	properties					1799:1808	good antibacterial properties	1780:1808	good antibacterial properties	1780:1808	The results suggest that the OBC/COL/CS is a fast and efficient procoagulant agent with good antibacterial properties and great potential for use as an absorbable hemostat for control of internal bleeding.
31880915	8	76	theme	platelets	1533:1541	arg1	adhesion					1504:1511	higher adhesion	1497:1511	higher adhesion of erythrocytes and platelets	1497:1541	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	8	76	theme	platelets	1533:1541	arg1	properties					1455:1464	greater procoagulant properties	1434:1464	greater procoagulant properties	1434:1464	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	2	77	theme	cationic	634:641	arg1	CS					643:644	cationic CS	634:644	cationic CS	634:644	In this study, a novel hemostatic nanocomposite (OBC/COL/CS) was fabricated by coupling oxidized bacterial cellulose (OBC) and chitosan (CS) with collagen (COL), that is, during the electrostatic self-assembly of OBC with CS (OBC/CS), COL was ingeniously attached as a functional component by the electrostatic attraction of cationic CS and anionic OBC.
31880915	8	78	theme	concomitant	1548:1558	arg1	loss					1572:1575	concomitant lower blood loss	1548:1575	concomitant lower blood loss	1548:1575	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	4	79	theme	composite	932:940	arg1	OBC/COL/CS					921:930	the OBC/COL/CS	917:930	the OBC/COL/CS composite for rapid internal hemostasis using a rat liver injury model	917:1001	This study is the first to evaluate the performance of OBC, OBC/CS, and the OBC/COL/CS composite for rapid internal hemostasis using a rat liver injury model.
31880915	8	80	theme	blood	1566:1570	arg1	loss					1572:1575	concomitant lower blood loss	1548:1575	concomitant lower blood loss	1548:1575	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	0	81	theme	Bacterial	62:70	arg1	Nanocellulose					72:84	Oxidized Bacterial Nanocellulose	53:84	Oxidized Bacterial Nanocellulose for Rapid Hemostasis and Wound Healing	53:123	A Biodegradable Antibacterial Nanocomposite Based on Oxidized Bacterial Nanocellulose for Rapid Hemostasis and Wound Healing.
31880915	4	82	theme	rapid	946:950	arg1	hemostasis					961:970	rapid internal hemostasis	946:970	rapid internal hemostasis using a rat liver injury model	946:1001	This study is the first to evaluate the performance of OBC, OBC/CS, and the OBC/COL/CS composite for rapid internal hemostasis using a rat liver injury model.
31880915	8	83	theme	commercial	1642:1651	arg1	gauze					1685:1689	the commercial hemostatic ORC product Surgicel gauze	1638:1689	the commercial hemostatic ORC product Surgicel gauze	1638:1689	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	5	84	theme	plant	1156:1160	arg1	ORC					1173:1175	ORC	1173:1175	ORC	1173:1175	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	5	84	theme	plant	1156:1160	arg1	cellulose					1162:1170	commercial hemostatic oxidized regenerated plant cellulose	1113:1170	commercial hemostatic oxidized regenerated plant cellulose (ORC)	1113:1176	To our knowledge, this is also the first study to report that OBC has a faster biodegradability in vivo than commercial hemostatic oxidized regenerated plant cellulose (ORC).
31880915	8	85	theme	ultrafast	1593:1601	arg1	cessation					1603:1611	ultrafast cessation	1593:1611	ultrafast cessation of bleeding	1593:1623	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	8	86	theme	ORC	1664:1666	arg1	gauze					1685:1689	the commercial hemostatic ORC product Surgicel gauze	1638:1689	the commercial hemostatic ORC product Surgicel gauze	1638:1689	OBC/COL/CS exhibited greater procoagulant properties and blood-clotting capability, higher adhesion of erythrocytes and platelets with concomitant lower blood loss, in addition to ultrafast cessation of bleeding, superior to the commercial hemostatic ORC product Surgicel gauze.
31880915	1	87	theme	noncompressible	265:279	arg1	wounds					281:286	deep noncompressible wounds	260:286	deep noncompressible wounds	260:286	The development of biodegradable and antibacterial hemostatic materials with high blood absorption to halt the internal hemorrhage of deep noncompressible wounds remains a challenge.
33104853	2	0	theme	cost	466:469	arg1	capsules					500:507	low cost, efficient, and slow-release capsules	462:507	low cost, efficient, and slow-release capsules	462:507	The studied formulations were prepared as hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag] and were applied to the bacterial strains to develop low cost, efficient, and slow-release capsules.
33104853	8	1	theme	slow-release	1318:1329	arg1	capacity					1331:1338	the slow-release capacity	1314:1338	the slow-release capacity of the capsules	1314:1354	The release kinetics revealed the slow-release capacity of the capsules mainly with the halloysite formulation which significantly released bacterial cells after 15 days of incubation in saline water (15.24 log CFU mL-1).
33104853	2	2	theme	alginate	343:350	arg1	[Ha-Ag					352:357	alginate [Ha-Ag	343:357	alginate [Ha-Ag	343:357	The studied formulations were prepared as hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag] and were applied to the bacterial strains to develop low cost, efficient, and slow-release capsules.
33104853	2	3	theme	low	462:464	arg1	capsules					500:507	low cost, efficient, and slow-release capsules	462:507	low cost, efficient, and slow-release capsules	462:507	The studied formulations were prepared as hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag] and were applied to the bacterial strains to develop low cost, efficient, and slow-release capsules.
33104853	4	4	theme	storage	839:845	arg1	3 months					827:834	3 months	827:834	3 months of storage	827:845	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	5	theme	different	853:861	arg1	conditions					863:872	different conditions	853:872	different conditions (room temperature vs 4 °C)	853:899	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	8	6	theme	bacterial	1424:1432	arg1	cells					1434:1438	bacterial cells	1424:1438	bacterial cells	1424:1438	The release kinetics revealed the slow-release capacity of the capsules mainly with the halloysite formulation which significantly released bacterial cells after 15 days of incubation in saline water (15.24 log CFU mL-1).
33104853	4	7	theme	survival	803:810	arg1	ratios					725:730	their swelling ratios	710:730	their swelling ratios	710:730	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	7	theme	survival	803:810	arg1	stability					812:820	their survival stability	797:820	their survival stability	797:820	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	9	8	theme	wheat	1541:1545	arg1	plants					1547:1552	wheat plants	1541:1552	wheat plants	1541:1552	The application of the capsules to wheat plants significantly increased root and shoot biomasses and nitrogen content in the roots.
33104853	5	9	theme	capsules	920:927	arg1	effect					906:911	The effect	902:911	The effect of the capsules on the growth of wheat plants	902:957	The effect of the capsules on the growth of wheat plants was also investigated.
33104853	1	10	theme	clay	245:248	arg1	minerals					250:257	clay minerals	245:257	clay minerals	245:257	This study aims to develop new formulations for microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf) and Azosprillum brasilense DSM1690 (Ab) using two kinds of clay minerals.
33104853	2	11	theme	slow-release	487:498	arg1	capsules					500:507	low cost, efficient, and slow-release capsules	462:507	low cost, efficient, and slow-release capsules	462:507	The studied formulations were prepared as hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag] and were applied to the bacterial strains to develop low cost, efficient, and slow-release capsules.
33104853	4	12	theme	soil	733:736	arg1	ratios					725:730	their swelling ratios	710:730	their swelling ratios	710:730	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	12	theme	soil	733:736	arg1	biodegradability					738:753	soil biodegradability	733:753	soil biodegradability	733:753	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	2	13	theme	studied	264:270	arg1	materials					309:317	hybrid materials	302:317	hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag]	302:407	The studied formulations were prepared as hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag] and were applied to the bacterial strains to develop low cost, efficient, and slow-release capsules.
33104853	2	13	theme	studied	264:270	arg1	formulations					272:283	The studied formulations	260:283	The studied formulations	260:283	The studied formulations were prepared as hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag] and were applied to the bacterial strains to develop low cost, efficient, and slow-release capsules.
33104853	1	14	theme	minerals	250:257	arg1	kinds					236:240	two kinds	232:240	two kinds of clay minerals	232:257	This study aims to develop new formulations for microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf) and Azosprillum brasilense DSM1690 (Ab) using two kinds of clay minerals.
33104853	4	15	theme	swelling	716:723	arg1	ratios					725:730	their swelling ratios	710:730	their swelling ratios	710:730	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	15	theme	swelling	716:723	arg1	biodegradability					738:753	soil biodegradability	733:753	soil biodegradability	733:753	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	15	theme	swelling	716:723	arg1	stability					812:820	their survival stability	797:820	their survival stability	797:820	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	15	theme	swelling	716:723	arg1	kinetics					764:771	release kinetics	756:771	release kinetics of microbial cells	756:790	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	16	theme	release	756:762	arg1	ratios					725:730	their swelling ratios	710:730	their swelling ratios	710:730	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	16	theme	release	756:762	arg1	kinetics					764:771	release kinetics	756:771	release kinetics of microbial cells	756:790	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	2	17	theme	alginate	383:390	arg1	polymers					392:399	alginate polymers	383:399	alginate polymers	383:399	The studied formulations were prepared as hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag] and were applied to the bacterial strains to develop low cost, efficient, and slow-release capsules.
33104853	4	18	from	shape	630:634	arg1	spherical					617:625	spherical	617:625	spherical	617:625	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	18	from	shape	630:634	arg1	capsules					603:610	The produced capsules	590:610	The produced capsules	590:610	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	10	19	theme	halloysite	1653:1662	arg1	minerals					1664:1671	halloysite minerals	1653:1671	halloysite minerals	1653:1671	In conclusion, halloysite minerals seem to be more adapted as additive to alginate in microbial encapsulation.
33104853	7	20	theme	swelling	1150:1157	arg1	ratios					1159:1164	The swelling ratios	1146:1164	The swelling ratios	1146:1164	The swelling ratios were ranged between 61.5 ± 1.35% and 36.5 ± 5% for the montmorillonite and the halloysite formulations, respectively.
33104853	2	21	theme	hybrid	302:307	arg1	materials					309:317	hybrid materials	302:317	hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag]	302:407	The studied formulations were prepared as hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag] and were applied to the bacterial strains to develop low cost, efficient, and slow-release capsules.
33104853	2	21	theme	hybrid	302:307	arg1	formulations					272:283	The studied formulations	260:283	The studied formulations	260:283	The studied formulations were prepared as hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag] and were applied to the bacterial strains to develop low cost, efficient, and slow-release capsules.
33104853	6	22	theme	halloysite	1122:1131	arg1	formulation					1133:1143	the halloysite formulation	1118:1143	the halloysite formulation	1118:1143	Results showed that both formulations were able to preserve bacterial survival which reached 14.8 log CFU g-1 after 3 months storage in the halloysite formulation.
33104853	4	23	from	spherical	617:625	arg1	shape					630:634	shape	630:634	shape	630:634	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	0	24	theme	Fertilizer	28:37	arg1	Bioformulation					0:13	Bioformulation	0:13	Bioformulation of Microbial Fertilizer	0:37	Bioformulation of Microbial Fertilizer Based on Clay and Alginate Encapsulation.
33104853	7	25	dep	montmorillonite	1221:1235	arg1	formulations					1256:1267	formulations	1256:1267	formulations	1256:1267	The swelling ratios were ranged between 61.5 ± 1.35% and 36.5 ± 5% for the montmorillonite and the halloysite formulations, respectively.
33104853	1	26	theme	Azosprillum	190:200	arg1	brasilense					202:211	Azosprillum brasilense DSM1690	190:219	Azosprillum brasilense DSM1690 (Ab)	190:224	This study aims to develop new formulations for microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf) and Azosprillum brasilense DSM1690 (Ab) using two kinds of clay minerals.
33104853	1	26	theme	Azosprillum	190:200	arg1	Ab					222:223	Ab	222:223	Ab	222:223	This study aims to develop new formulations for microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf) and Azosprillum brasilense DSM1690 (Ab) using two kinds of clay minerals.
33104853	0	27	theme	Microbial	18:26	arg1	Fertilizer					28:37	Microbial Fertilizer	18:37	Microbial Fertilizer	18:37	Bioformulation of Microbial Fertilizer Based on Clay and Alginate Encapsulation.
33104853	8	28	theme	capsules	1347:1354	arg1	capacity					1331:1338	the slow-release capacity	1314:1338	the slow-release capacity of the capsules	1314:1354	The release kinetics revealed the slow-release capacity of the capsules mainly with the halloysite formulation which significantly released bacterial cells after 15 days of incubation in saline water (15.24 log CFU mL-1).
33104853	8	29	theme	incubation	1457:1466	arg1	15 days					1446:1452	15 days	1446:1452	15 days of incubation in saline water (15.24 log CFU mL-1)	1446:1503	The release kinetics revealed the slow-release capacity of the capsules mainly with the halloysite formulation which significantly released bacterial cells after 15 days of incubation in saline water (15.24 log CFU mL-1).
33104853	1	30	dep	Pseudomonas	151:161	arg1	fluorescens					163:173	fluorescens	163:173	fluorescens	163:173	This study aims to develop new formulations for microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf) and Azosprillum brasilense DSM1690 (Ab) using two kinds of clay minerals.
33104853	4	31	theme	produced	594:601	arg1	spherical					617:625	spherical	617:625	spherical	617:625	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	31	theme	produced	594:601	arg1	capsules					603:610	The produced capsules	590:610	The produced capsules	590:610	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	32	dep	conditions	863:872	arg1	temperature					880:890	room temperature	875:890	room temperature	875:890	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	32	dep	conditions	863:872	arg1	4 °C					895:898	4 °C	895:898	4 °C	895:898	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	9	33	theme	root	1578:1581	arg1	biomasses					1593:1601	root and shoot biomasses	1578:1601	biomasses	1593:1601	The application of the capsules to wheat plants significantly increased root and shoot biomasses and nitrogen content in the roots.
33104853	8	34	from	15 days	1446:1452	arg1	water					1478:1482	saline water	1471:1482	saline water (15.24 log CFU mL-1)	1471:1503	The release kinetics revealed the slow-release capacity of the capsules mainly with the halloysite formulation which significantly released bacterial cells after 15 days of incubation in saline water (15.24 log CFU mL-1).
33104853	8	34	from	15 days	1446:1452	arg1	CFU mL-1					1495:1502	15.24 log CFU mL-1	1485:1502	15.24 log CFU mL-1	1485:1502	The release kinetics revealed the slow-release capacity of the capsules mainly with the halloysite formulation which significantly released bacterial cells after 15 days of incubation in saline water (15.24 log CFU mL-1).
33104853	9	35	theme	capsules	1529:1536	arg1	application					1510:1520	The application	1506:1520	The application of the capsules to wheat plants	1506:1552	The application of the capsules to wheat plants significantly increased root and shoot biomasses and nitrogen content in the roots.
33104853	6	36	theme	bacterial	1042:1050	arg1	survival					1052:1059	bacterial survival	1042:1059	bacterial survival which reached 14.8 log CFU g-1 after 3 months storage in the halloysite formulation	1042:1143	Results showed that both formulations were able to preserve bacterial survival which reached 14.8 log CFU g-1 after 3 months storage in the halloysite formulation.
33104853	8	37	theme	saline	1471:1476	arg1	water					1478:1482	saline water	1471:1482	saline water (15.24 log CFU mL-1)	1471:1503	The release kinetics revealed the slow-release capacity of the capsules mainly with the halloysite formulation which significantly released bacterial cells after 15 days of incubation in saline water (15.24 log CFU mL-1).
33104853	8	37	theme	saline	1471:1476	arg1	CFU mL-1					1495:1502	15.24 log CFU mL-1	1485:1502	15.24 log CFU mL-1	1485:1502	The release kinetics revealed the slow-release capacity of the capsules mainly with the halloysite formulation which significantly released bacterial cells after 15 days of incubation in saline water (15.24 log CFU mL-1).
33104853	0	38	dep	Clay	48:51	arg1	Encapsulation					66:78	Encapsulation	66:78	Encapsulation	66:78	Bioformulation of Microbial Fertilizer Based on Clay and Alginate Encapsulation.
33104853	9	39	theme	shoot	1587:1591	arg1	biomasses					1593:1601	root and shoot biomasses	1578:1601	biomasses	1593:1601	The application of the capsules to wheat plants significantly increased root and shoot biomasses and nitrogen content in the roots.
33104853	10	40	theme	microbial	1724:1732	arg1	encapsulation					1734:1746	microbial encapsulation	1724:1746	microbial encapsulation	1724:1746	In conclusion, halloysite minerals seem to be more adapted as additive to alginate in microbial encapsulation.
33104853	4	41	theme	room	875:878	arg1	temperature					880:890	room temperature	875:890	room temperature	875:890	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	3	42	theme	alginate	560:567	arg1	[Ag					569:571	alginate [Ag	560:571	alginate [Ag	560:571	Their efficiency was evaluated in comparison with alginate [Ag] as the control.
33104853	6	43	theme	14.8 log	1075:1082	arg1	CFU g-1					1084:1090	14.8 log CFU g-1	1075:1090	14.8 log CFU g-1	1075:1090	Results showed that both formulations were able to preserve bacterial survival which reached 14.8 log CFU g-1 after 3 months storage in the halloysite formulation.
33104853	1	44	theme	new	108:110	arg1	formulations					112:123	new formulations	108:123	new formulations for microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf) and Azosprillum brasilense DSM1690 (Ab)	108:224	This study aims to develop new formulations for microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf) and Azosprillum brasilense DSM1690 (Ab) using two kinds of clay minerals.
33104853	2	45	theme	bacterial	433:441	arg1	strains					443:449	the bacterial strains	429:449	the bacterial strains	429:449	The studied formulations were prepared as hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag] and were applied to the bacterial strains to develop low cost, efficient, and slow-release capsules.
33104853	6	46	from	storage	1107:1113	arg1	formulation					1133:1143	the halloysite formulation	1118:1143	the halloysite formulation	1118:1143	Results showed that both formulations were able to preserve bacterial survival which reached 14.8 log CFU g-1 after 3 months storage in the halloysite formulation.
33104853	6	47	theme	3 months	1098:1105	arg1	storage					1107:1113	3 months storage	1098:1113	3 months storage in the halloysite formulation	1098:1143	Results showed that both formulations were able to preserve bacterial survival which reached 14.8 log CFU g-1 after 3 months storage in the halloysite formulation.
33104853	3	48	with	comparison	544:553	arg1	[Ag					569:571	alginate [Ag	560:571	alginate [Ag	560:571	Their efficiency was evaluated in comparison with alginate [Ag] as the control.
33104853	5	49	theme	wheat	946:950	arg1	plants					952:957	wheat plants	946:957	wheat plants	946:957	The effect of the capsules on the growth of wheat plants was also investigated.
33104853	2	50	dep	montmorillonite	363:377	arg1	[Mt-Ag					401:406	[Mt-Ag	401:406	[Mt-Ag	401:406	The studied formulations were prepared as hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag] and were applied to the bacterial strains to develop low cost, efficient, and slow-release capsules.
33104853	9	51	theme	nitrogen	1607:1614	arg1	content					1616:1622	nitrogen content	1607:1622	nitrogen content	1607:1622	The application of the capsules to wheat plants significantly increased root and shoot biomasses and nitrogen content in the roots.
33104853	8	52	theme	release	1288:1294	arg1	kinetics					1296:1303	The release kinetics	1284:1303	The release kinetics	1284:1303	The release kinetics revealed the slow-release capacity of the capsules mainly with the halloysite formulation which significantly released bacterial cells after 15 days of incubation in saline water (15.24 log CFU mL-1).
33104853	8	53	theme	halloysite	1372:1381	arg1	formulation					1383:1393	the halloysite formulation	1368:1393	the halloysite formulation which significantly released bacterial cells after 15 days of incubation in saline water (15.24 log CFU mL-1)	1368:1503	The release kinetics revealed the slow-release capacity of the capsules mainly with the halloysite formulation which significantly released bacterial cells after 15 days of incubation in saline water (15.24 log CFU mL-1).
33104853	5	54	theme	plants	952:957	arg1	growth					936:941	the growth	932:941	the growth of wheat plants	932:957	The effect of the capsules on the growth of wheat plants was also investigated.
33104853	1	55	theme	microbial	129:137	arg1	Pf					182:183	Pf	182:183	Pf	182:183	This study aims to develop new formulations for microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf) and Azosprillum brasilense DSM1690 (Ab) using two kinds of clay minerals.
33104853	1	55	theme	microbial	129:137	arg1	Ms-01					175:179	microbial fertilizers Pseudomonas fluorescens Ms-01	129:179	microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf)	129:184	This study aims to develop new formulations for microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf) and Azosprillum brasilense DSM1690 (Ab) using two kinds of clay minerals.
33104853	5	56	from	effect	906:911	arg1	growth					936:941	the growth	932:941	the growth of wheat plants	932:957	The effect of the capsules on the growth of wheat plants was also investigated.
33104853	2	57	theme	efficient	472:480	arg1	capsules					500:507	low cost, efficient, and slow-release capsules	462:507	low cost, efficient, and slow-release capsules	462:507	The studied formulations were prepared as hybrid materials based on halloysite and alginate [Ha-Ag] or montmorillonite and alginate polymers [Mt-Ag] and were applied to the bacterial strains to develop low cost, efficient, and slow-release capsules.
33104853	8	58	theme	15.24 log	1485:1493	arg1	water					1478:1482	saline water	1471:1482	saline water (15.24 log CFU mL-1)	1471:1503	The release kinetics revealed the slow-release capacity of the capsules mainly with the halloysite formulation which significantly released bacterial cells after 15 days of incubation in saline water (15.24 log CFU mL-1).
33104853	8	58	theme	15.24 log	1485:1493	arg1	CFU mL-1					1495:1502	15.24 log CFU mL-1	1485:1502	15.24 log CFU mL-1	1485:1502	The release kinetics revealed the slow-release capacity of the capsules mainly with the halloysite formulation which significantly released bacterial cells after 15 days of incubation in saline water (15.24 log CFU mL-1).
33104853	4	59	theme	cells	786:790	arg1	ratios					725:730	their swelling ratios	710:730	their swelling ratios	710:730	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	59	theme	cells	786:790	arg1	biodegradability					738:753	soil biodegradability	733:753	soil biodegradability	733:753	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	59	theme	cells	786:790	arg1	kinetics					764:771	release kinetics	756:771	release kinetics of microbial cells	756:790	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	4	59	theme	cells	786:790	arg1	stability					812:820	their survival stability	797:820	their survival stability	797:820	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	1	60	theme	fertilizers	139:149	arg1	Pf					182:183	Pf	182:183	Pf	182:183	This study aims to develop new formulations for microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf) and Azosprillum brasilense DSM1690 (Ab) using two kinds of clay minerals.
33104853	1	60	theme	fertilizers	139:149	arg1	Ms-01					175:179	microbial fertilizers Pseudomonas fluorescens Ms-01	129:179	microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf)	129:184	This study aims to develop new formulations for microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf) and Azosprillum brasilense DSM1690 (Ab) using two kinds of clay minerals.
33104853	4	61	theme	microbial	776:784	arg1	cells					786:790	microbial cells	776:790	microbial cells	776:790	The produced capsules were spherical in shape and were chemically and physically characterized and further analyzed for their swelling ratios, soil biodegradability, release kinetics of microbial cells, and their survival stability over 3 months of storage under different conditions (room temperature vs 4 °C).
33104853	1	62	theme	Pseudomonas	151:161	arg1	Pf					182:183	Pf	182:183	Pf	182:183	This study aims to develop new formulations for microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf) and Azosprillum brasilense DSM1690 (Ab) using two kinds of clay minerals.
33104853	1	62	theme	Pseudomonas	151:161	arg1	Ms-01					175:179	microbial fertilizers Pseudomonas fluorescens Ms-01	129:179	microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf)	129:184	This study aims to develop new formulations for microbial fertilizers Pseudomonas fluorescens Ms-01 (Pf) and Azosprillum brasilense DSM1690 (Ab) using two kinds of clay minerals.
34235650	5	0	theme	important	784:792	arg1	overhang					794:801	important overhang	784:801	important overhang	784:801	In addition, as the use of physical methods has brought important overhang on chemical structures of the very-long-chain MA, which typify mycobacteria, NMR and mass spectrometry data of these specific fatty acids are included.
34235650	3	1	theme	wall-linked	520:530	arg1	MA					547:548	MA	547:548	MA	547:548	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	3	1	theme	wall-linked	520:530	arg1	acids					540:544	cell wall-linked mycolic acids	515:544	cell wall-linked mycolic acids (MA)	515:549	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	5	2	theme	acids	935:939	arg1	data					906:909	NMR and mass spectrometry data	880:909	NMR and mass spectrometry data of these specific fatty acids	880:939	In addition, as the use of physical methods has brought important overhang on chemical structures of the very-long-chain MA, which typify mycobacteria, NMR and mass spectrometry data of these specific fatty acids are included.
34235650	3	3	theme	mycolic	532:538	arg1	MA					547:548	MA	547:548	MA	547:548	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	3	3	theme	mycolic	532:538	arg1	acids					540:544	cell wall-linked mycolic acids	515:544	cell wall-linked mycolic acids (MA)	515:549	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	2	4	theme	type-species	295:306	arg1	levels					308:313	the species and type-species levels	279:313	the species and type-species levels	279:313	As such the lipid composition is commonly used to characterize mycobacterial strains at the species and type-species levels.
34235650	4	5	theme	various	595:601	arg1	techniques					619:628	various chromatographic techniques	595:628	various chromatographic techniques	595:628	These involve various chromatographic techniques and analytical procedures necessary for structural and metabolic studies of mycobacterial lipids.
34235650	1	6	theme	high	69:72	arg1	content					74:80	The very high content	60:80	The very high content of structurally diverse and biologically active lipids of exotic structures	60:156	The very high content of structurally diverse and biologically active lipids of exotic structures is the hallmark of Mycobacteria.
34235650	1	6	theme	high	69:72	arg1	hallmark					165:172	the hallmark	161:172	the hallmark of Mycobacteria	161:188	The very high content of structurally diverse and biologically active lipids of exotic structures is the hallmark of Mycobacteria.
34235650	5	7	theme	NMR	880:882	arg1	data					906:909	NMR and mass spectrometry data	880:909	NMR and mass spectrometry data of these specific fatty acids	880:939	In addition, as the use of physical methods has brought important overhang on chemical structures of the very-long-chain MA, which typify mycobacteria, NMR and mass spectrometry data of these specific fatty acids are included.
34235650	5	8	theme	physical	755:762	arg1	methods					764:770	physical methods	755:770	physical methods	755:770	In addition, as the use of physical methods has brought important overhang on chemical structures of the very-long-chain MA, which typify mycobacteria, NMR and mass spectrometry data of these specific fatty acids are included.
34235650	5	9	theme	fatty	929:933	arg1	acids					935:939	these specific fatty acids	914:939	these specific fatty acids	914:939	In addition, as the use of physical methods has brought important overhang on chemical structures of the very-long-chain MA, which typify mycobacteria, NMR and mass spectrometry data of these specific fatty acids are included.
34235650	2	10	theme	species	283:289	arg1	levels					308:313	the species and type-species levels	279:313	the species and type-species levels	279:313	As such the lipid composition is commonly used to characterize mycobacterial strains at the species and type-species levels.
34235650	4	11	theme	metabolic	685:693	arg1	studies					695:701	structural and metabolic studies	670:701	structural and metabolic studies of mycobacterial lipids	670:725	These involve various chromatographic techniques and analytical procedures necessary for structural and metabolic studies of mycobacterial lipids.
34235650	5	12	theme	methods	764:770	arg1	use					748:750	the use	744:750	the use of physical methods	744:770	In addition, as the use of physical methods has brought important overhang on chemical structures of the very-long-chain MA, which typify mycobacteria, NMR and mass spectrometry data of these specific fatty acids are included.
34235650	1	13	theme	Mycobacteria	177:188	arg1	content					74:80	The very high content	60:80	The very high content of structurally diverse and biologically active lipids of exotic structures	60:156	The very high content of structurally diverse and biologically active lipids of exotic structures is the hallmark of Mycobacteria.
34235650	1	13	theme	Mycobacteria	177:188	arg1	hallmark					165:172	the hallmark	161:172	the hallmark of Mycobacteria	161:188	The very high content of structurally diverse and biologically active lipids of exotic structures is the hallmark of Mycobacteria.
34235650	5	14	theme	mass	888:891	arg1	spectrometry					893:904	mass spectrometry	888:904	mass spectrometry	888:904	In addition, as the use of physical methods has brought important overhang on chemical structures of the very-long-chain MA, which typify mycobacteria, NMR and mass spectrometry data of these specific fatty acids are included.
34235650	5	15	theme	very-long-chain	833:847	arg1	MA					849:850	the very-long-chain MA	829:850	the very-long-chain MA	829:850	In addition, as the use of physical methods has brought important overhang on chemical structures of the very-long-chain MA, which typify mycobacteria, NMR and mass spectrometry data of these specific fatty acids are included.
34235650	1	16	theme	diverse	98:104	arg1	lipids					130:135	structurally diverse and biologically active lipids	85:135	structurally diverse and biologically active lipids of exotic structures	85:156	The very high content of structurally diverse and biologically active lipids of exotic structures is the hallmark of Mycobacteria.
34235650	3	17	theme	those	447:451	arg1	purification					373:384	the purification	369:384	the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM)	369:578	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	5	18	theme	MA	849:850	arg1	structures					815:824	chemical structures	806:824	chemical structures of the very-long-chain MA, which typify mycobacteria	806:877	In addition, as the use of physical methods has brought important overhang on chemical structures of the very-long-chain MA, which typify mycobacteria, NMR and mass spectrometry data of these specific fatty acids are included.
34235650	3	19	link	wall-linked	520:530	arg1	MA					547:548	MA	547:548	MA	547:548	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	3	19	link	wall-linked	520:530	arg1	acids					540:544	cell wall-linked mycolic acids	515:544	cell wall-linked mycolic acids (MA)	515:549	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	4	20	theme	necessary	656:664	arg1	techniques					619:628	various chromatographic techniques	595:628	various chromatographic techniques	595:628	These involve various chromatographic techniques and analytical procedures necessary for structural and metabolic studies of mycobacterial lipids.
34235650	5	21	theme	specific	920:927	arg1	acids					935:939	these specific fatty acids	914:939	these specific fatty acids	914:939	In addition, as the use of physical methods has brought important overhang on chemical structures of the very-long-chain MA, which typify mycobacteria, NMR and mass spectrometry data of these specific fatty acids are included.
34235650	2	22	used	used	233:236	arg2	composition					209:219	the lipid composition	199:219	the lipid composition	199:219	As such the lipid composition is commonly used to characterize mycobacterial strains at the species and type-species levels.
34235650	2	22	used	used	233:236	arg2	such					194:197	such	194:197	such	194:197	As such the lipid composition is commonly used to characterize mycobacterial strains at the species and type-species levels.
34235650	4	23	theme	lipids	720:725	arg1	studies					695:701	structural and metabolic studies	670:701	structural and metabolic studies of mycobacterial lipids	670:725	These involve various chromatographic techniques and analytical procedures necessary for structural and metabolic studies of mycobacterial lipids.
34235650	3	24	theme	active	429:434	arg1	lipids					436:441	the most commonly isolated biologically active lipids	389:441	the most commonly isolated biologically active lipids	389:441	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	3	25	theme	cell	515:518	arg1	MA					547:548	MA	547:548	MA	547:548	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	3	25	theme	cell	515:518	arg1	acids					540:544	cell wall-linked mycolic acids	515:544	cell wall-linked mycolic acids (MA)	515:549	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	5	26	theme	spectrometry	893:904	arg1	data					906:909	NMR and mass spectrometry data	880:909	NMR and mass spectrometry data of these specific fatty acids	880:939	In addition, as the use of physical methods has brought important overhang on chemical structures of the very-long-chain MA, which typify mycobacteria, NMR and mass spectrometry data of these specific fatty acids are included.
34235650	4	27	theme	structural	670:679	arg1	studies					695:701	structural and metabolic studies	670:701	structural and metabolic studies of mycobacterial lipids	670:725	These involve various chromatographic techniques and analytical procedures necessary for structural and metabolic studies of mycobacterial lipids.
34235650	3	28	theme	lipids	436:441	arg1	purification					373:384	the purification	369:384	the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM)	369:578	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	5	29	theme	chemical	806:813	arg1	structures					815:824	chemical structures	806:824	chemical structures of the very-long-chain MA, which typify mycobacteria	806:877	In addition, as the use of physical methods has brought important overhang on chemical structures of the very-long-chain MA, which typify mycobacteria, NMR and mass spectrometry data of these specific fatty acids are included.
34235650	3	30	theme	extractable	472:482	arg1	lipids					484:489	extractable lipids	472:489	extractable lipids	472:489	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	3	31	theme	isolated	407:414	arg1	lipids					436:441	the most commonly isolated biologically active lipids	389:441	the most commonly isolated biologically active lipids	389:441	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	1	32	theme	active	123:128	arg1	lipids					130:135	structurally diverse and biologically active lipids	85:135	structurally diverse and biologically active lipids of exotic structures	85:156	The very high content of structurally diverse and biologically active lipids of exotic structures is the hallmark of Mycobacteria.
34235650	3	33	theme	present	320:326	arg1	chapter					328:334	The present chapter	316:334	The present chapter	316:334	The present chapter describes the methods that allow the purification of the most commonly isolated biologically active lipids and those used for analyzing extractable lipids and their constituents, cell wall-linked mycolic acids (MA), and lipoarabinomannan (LAM).
34235650	1	34	theme	lipids	130:135	arg1	content					74:80	The very high content	60:80	The very high content of structurally diverse and biologically active lipids of exotic structures	60:156	The very high content of structurally diverse and biologically active lipids of exotic structures is the hallmark of Mycobacteria.
34235650	1	34	theme	lipids	130:135	arg1	hallmark					165:172	the hallmark	161:172	the hallmark of Mycobacteria	161:188	The very high content of structurally diverse and biologically active lipids of exotic structures is the hallmark of Mycobacteria.
34235650	2	35	theme	lipid	203:207	arg1	such					194:197	such	194:197	such	194:197	As such the lipid composition is commonly used to characterize mycobacterial strains at the species and type-species levels.
34235650	2	35	theme	lipid	203:207	arg1	composition					209:219	the lipid composition	199:219	the lipid composition	199:219	As such the lipid composition is commonly used to characterize mycobacterial strains at the species and type-species levels.
34235650	0	36	dep	Isolation	28:36	arg1	Lipoarabinomannan					10:26	Lipoarabinomannan	10:26	Lipoarabinomannan	10:26	Lipid and Lipoarabinomannan Isolation and Characterization.
34235650	0	36	dep	Isolation	28:36	arg1	Lipid					0:4	Lipid	0:4	Lipid	0:4	Lipid and Lipoarabinomannan Isolation and Characterization.
34235650	1	37	theme	exotic	140:145	arg1	structures					147:156	exotic structures	140:156	exotic structures	140:156	The very high content of structurally diverse and biologically active lipids of exotic structures is the hallmark of Mycobacteria.
34235650	4	38	theme	chromatographic	603:617	arg1	techniques					619:628	various chromatographic techniques	595:628	various chromatographic techniques	595:628	These involve various chromatographic techniques and analytical procedures necessary for structural and metabolic studies of mycobacterial lipids.
34235650	2	39	theme	mycobacterial	254:266	arg1	strains					268:274	mycobacterial strains	254:274	mycobacterial strains	254:274	As such the lipid composition is commonly used to characterize mycobacterial strains at the species and type-species levels.
34235650	1	40	theme	structures	147:156	arg1	lipids					130:135	structurally diverse and biologically active lipids	85:135	structurally diverse and biologically active lipids of exotic structures	85:156	The very high content of structurally diverse and biologically active lipids of exotic structures is the hallmark of Mycobacteria.
34235650	4	41	theme	analytical	634:643	arg1	procedures					645:654	analytical procedures	634:654	analytical procedures	634:654	These involve various chromatographic techniques and analytical procedures necessary for structural and metabolic studies of mycobacterial lipids.
34235650	4	42	theme	mycobacterial	706:718	arg1	lipids					720:725	mycobacterial lipids	706:725	mycobacterial lipids	706:725	These involve various chromatographic techniques and analytical procedures necessary for structural and metabolic studies of mycobacterial lipids.
32297891	4	0	located	detected	770:777	arg2	fluorophores					757:768	the molecular fluorophores	743:768	the molecular fluorophores detected in CNDs	743:785	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	0	located	detected	770:777	arg1	CNDs					782:785	CNDs	782:785	CNDs	782:785	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	1	theme	molecular	747:755	arg1	fluorophores					757:768	the molecular fluorophores	743:768	the molecular fluorophores detected in CNDs	743:785	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	5	2	theme	activity	1283:1290	arg1	determination					1252:1264	the determination	1248:1264	the determination of the enzymatic activity based on the quenching by p-nitrophenol	1248:1330	We have deconstructed the CND-CD systems to demonstrate that (i) the role of CNDs is limited to acting as a support for the molecular fluorophores produced during their synthesis and (ii) the molecular fluorophores suffice for the determination of the enzymatic activity based on the quenching by p-nitrophenol as a sacrificial quencher.
32297891	5	3	theme	molecular	1213:1221	arg1	fluorophores					1223:1234	the molecular fluorophores	1209:1234	the molecular fluorophores	1209:1234	We have deconstructed the CND-CD systems to demonstrate that (i) the role of CNDs is limited to acting as a support for the molecular fluorophores produced during their synthesis and (ii) the molecular fluorophores suffice for the determination of the enzymatic activity based on the quenching by p-nitrophenol as a sacrificial quencher.
32297891	4	4	dep	"	937:937	arg1	biosensors					939:948	biosensors	939:948	biosensors suitable for the analysis of cholesterol and β-galactosidase activity	939:1018	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	5	theme	CD	922:923	arg1	"					937:937	CND-based CD "turn off-on"	912:937	CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity	912:1018	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	1	6	theme	cyclodextrins	184:196	arg1	capabilities					168:179	the supramolecular loading capabilities	141:179	the supramolecular loading capabilities of cyclodextrins (CDs) with the optical properties of the affixed chromophores	141:258	Chromophore-appended cyclodextrins combine the supramolecular loading capabilities of cyclodextrins (CDs) with the optical properties of the affixed chromophores.
32297891	4	7	theme	β-galactosidase	995:1009	arg1	activity					1011:1018	β-galactosidase activity	995:1018	β-galactosidase activity	995:1018	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	2	8	theme	CDs	360:362	arg1	feasibility					332:342	the feasibility	328:342	the feasibility of CND-appended CDs as sensors	328:373	Among fluorescent materials, carbon dots (CNDs) are attractive and the feasibility of CND-appended CDs as sensors has been demonstrated by different authors.
32297891	4	9	theme	fluorescence	618:629	arg1	properties					631:640	the fluorescence properties	614:640	the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs	614:785	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	10	theme	pyridine-7-carboxylic	683:703	arg1	paradigmatic					727:738	the most paradigmatic	718:738	the most paradigmatic of the molecular fluorophores detected in CNDs	718:785	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	10	theme	pyridine-7-carboxylic	683:703	arg1	IPCA					711:714	IPCA	711:714	IPCA	711:714	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	10	theme	pyridine-7-carboxylic	683:703	arg1	acid					705:708	5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid	645:708	5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA)	645:715	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	1	11	with	capabilities	168:179	arg1	properties					221:230	the optical properties	209:230	the optical properties of the affixed chromophores	209:258	Chromophore-appended cyclodextrins combine the supramolecular loading capabilities of cyclodextrins (CDs) with the optical properties of the affixed chromophores.
32297891	5	12	theme	CND-CD	1047:1052	arg1	systems					1054:1060	the CND-CD systems	1043:1060	the CND-CD systems	1043:1060	We have deconstructed the CND-CD systems to demonstrate that (i) the role of CNDs is limited to acting as a support for the molecular fluorophores produced during their synthesis and (ii) the molecular fluorophores suffice for the determination of the enzymatic activity based on the quenching by p-nitrophenol as a sacrificial quencher.
32297891	3	13	theme	hybrid	519:524	arg1	composites					526:535	hybrid composites	519:535	hybrid composites	519:535	However, CNDs are intrinsically heterogeneous materials and their ulterior functionalization yields hybrid composites that are not well defined in terms of structure and composition.
32297891	3	14	theme	ulterior	485:492	arg1	yields					512:517	their ulterior functionalization yields	479:517	their ulterior functionalization yields	479:517	However, CNDs are intrinsically heterogeneous materials and their ulterior functionalization yields hybrid composites that are not well defined in terms of structure and composition.
32297891	4	15	theme	synthetic	826:834	arg1	strategies					845:854	two highly efficient synthetic chemical strategies	805:854	two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity	805:1018	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	2	16	theme	different	400:408	arg1	authors					410:416	different authors	400:416	different authors	400:416	Among fluorescent materials, carbon dots (CNDs) are attractive and the feasibility of CND-appended CDs as sensors has been demonstrated by different authors.
32297891	4	17	theme	activity	1011:1018	arg1	analysis					967:974	the analysis	963:974	the analysis of cholesterol and β-galactosidase activity	963:1018	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	2	18	theme	carbon	290:295	arg1	CNDs					303:306	CNDs	303:306	CNDs	303:306	Among fluorescent materials, carbon dots (CNDs) are attractive and the feasibility of CND-appended CDs as sensors has been demonstrated by different authors.
32297891	2	18	theme	carbon	290:295	arg1	dots					297:300	carbon dots	290:300	carbon dots (CNDs)	290:307	Among fluorescent materials, carbon dots (CNDs) are attractive and the feasibility of CND-appended CDs as sensors has been demonstrated by different authors.
32297891	3	19	theme	heterogeneous	451:463	arg1	CNDs					428:431	CNDs	428:431	CNDs	428:431	However, CNDs are intrinsically heterogeneous materials and their ulterior functionalization yields hybrid composites that are not well defined in terms of structure and composition.
32297891	3	19	theme	heterogeneous	451:463	arg1	materials					465:473	intrinsically heterogeneous materials	437:473	intrinsically heterogeneous materials	437:473	However, CNDs are intrinsically heterogeneous materials and their ulterior functionalization yields hybrid composites that are not well defined in terms of structure and composition.
32297891	0	20	theme	dots-inspired	7:19	arg1	cyclodextrins					33:45	Carbon dots-inspired fluorescent cyclodextrins	0:45	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.	0:96	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.
32297891	4	21	theme	CND-based	912:920	arg1	"					937:937	CND-based CD "turn off-on"	912:937	CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity	912:1018	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	3	22	theme	composition	589:599	arg1	terms					566:570	terms	566:570	terms of structure and composition	566:599	However, CNDs are intrinsically heterogeneous materials and their ulterior functionalization yields hybrid composites that are not well defined in terms of structure and composition.
32297891	4	23	theme	most	722:725	arg1	paradigmatic					727:738	the most paradigmatic	718:738	the most paradigmatic of the molecular fluorophores detected in CNDs	718:785	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	23	theme	most	722:725	arg1	acid					705:708	5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid	645:708	5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA)	645:715	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	0	24	theme	Carbon	0:5	arg1	cyclodextrins					33:45	Carbon dots-inspired fluorescent cyclodextrins	0:45	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.	0:96	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.
32297891	3	25	theme	structure	575:583	arg1	terms					566:570	terms	566:570	terms of structure and composition	566:599	However, CNDs are intrinsically heterogeneous materials and their ulterior functionalization yields hybrid composites that are not well defined in terms of structure and composition.
32297891	4	26	theme	acid	705:708	arg1	properties					631:640	the fluorescence properties	614:640	the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs	614:785	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	0	27	theme	fluorescent	21:31	arg1	cyclodextrins					33:45	Carbon dots-inspired fluorescent cyclodextrins	0:45	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.	0:96	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.
32297891	5	28	theme	molecular	1145:1153	arg1	fluorophores					1155:1166	the molecular fluorophores	1141:1166	the molecular fluorophores produced during their synthesis	1141:1198	We have deconstructed the CND-CD systems to demonstrate that (i) the role of CNDs is limited to acting as a support for the molecular fluorophores produced during their synthesis and (ii) the molecular fluorophores suffice for the determination of the enzymatic activity based on the quenching by p-nitrophenol as a sacrificial quencher.
32297891	1	29	theme	Chromophore-appended	98:117	arg1	cyclodextrins					119:131	Chromophore-appended cyclodextrins	98:131	Chromophore-appended cyclodextrins	98:131	Chromophore-appended cyclodextrins combine the supramolecular loading capabilities of cyclodextrins (CDs) with the optical properties of the affixed chromophores.
32297891	5	30	theme	sacrificial	1337:1347	arg1	quencher					1349:1356	a sacrificial quencher	1335:1356	a sacrificial quencher	1335:1356	We have deconstructed the CND-CD systems to demonstrate that (i) the role of CNDs is limited to acting as a support for the molecular fluorophores produced during their synthesis and (ii) the molecular fluorophores suffice for the determination of the enzymatic activity based on the quenching by p-nitrophenol as a sacrificial quencher.
32297891	1	31	theme	optical	213:219	arg1	properties					221:230	the optical properties	209:230	the optical properties of the affixed chromophores	209:258	Chromophore-appended cyclodextrins combine the supramolecular loading capabilities of cyclodextrins (CDs) with the optical properties of the affixed chromophores.
32297891	0	32	theme	competitive	48:58	arg1	bio					85:87	bio	85:87	bio	85:87	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.
32297891	0	32	theme	competitive	48:58	arg1	"					82:82	competitive supramolecular "off-on"	48:82	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.	0:96	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.
32297891	4	33	theme	fluorophores	757:768	arg1	paradigmatic					727:738	the most paradigmatic	718:738	the most paradigmatic of the molecular fluorophores detected in CNDs	718:785	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	33	theme	fluorophores	757:768	arg1	acid					705:708	5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid	645:708	5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA)	645:715	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	34	theme	cholesterol	979:989	arg1	analysis					967:974	the analysis	963:974	the analysis of cholesterol and β-galactosidase activity	963:1018	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	35	theme	CDs	893:895	arg1	preparation					864:874	the preparation	860:874	the preparation of IPCA-appended CDs	860:895	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	2	36	theme	CND-appended	347:358	arg1	CDs					360:362	CND-appended CDs	347:362	CND-appended CDs	347:362	Among fluorescent materials, carbon dots (CNDs) are attractive and the feasibility of CND-appended CDs as sensors has been demonstrated by different authors.
32297891	0	37	theme	supramolecular	60:73	arg1	bio					85:87	bio	85:87	bio	85:87	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.
32297891	0	37	theme	supramolecular	60:73	arg1	"					82:82	competitive supramolecular "off-on"	48:82	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.	0:96	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.
32297891	5	38	dep	suffice	1236:1242	arg1	ii					1205:1206	ii	1205:1206	ii	1205:1206	We have deconstructed the CND-CD systems to demonstrate that (i) the role of CNDs is limited to acting as a support for the molecular fluorophores produced during their synthesis and (ii) the molecular fluorophores suffice for the determination of the enzymatic activity based on the quenching by p-nitrophenol as a sacrificial quencher.
32297891	4	39	theme	IPCA-appended	879:891	arg1	CDs					893:895	IPCA-appended CDs	879:895	IPCA-appended CDs	879:895	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	40	theme	off-on	931:936	arg1	"					937:937	CND-based CD "turn off-on"	912:937	CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity	912:1018	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	3	41	dep	materials	465:473	arg1	composites					526:535	hybrid composites	519:535	hybrid composites	519:535	However, CNDs are intrinsically heterogeneous materials and their ulterior functionalization yields hybrid composites that are not well defined in terms of structure and composition.
32297891	0	42	dep	cyclodextrins	33:45	arg1	sensors					89:95	competitive supramolecular "off-on" (bio)sensors	48:95	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.	0:96	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.
32297891	3	43	theme	functionalization	494:510	arg1	yields					512:517	their ulterior functionalization yields	479:517	their ulterior functionalization yields	479:517	However, CNDs are intrinsically heterogeneous materials and their ulterior functionalization yields hybrid composites that are not well defined in terms of structure and composition.
32297891	4	44	theme	efficient	816:824	arg1	strategies					845:854	two highly efficient synthetic chemical strategies	805:854	two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity	805:1018	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	45	theme	chemical	836:843	arg1	strategies					845:854	two highly efficient synthetic chemical strategies	805:854	two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity	805:1018	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	1	46	theme	supramolecular	145:158	arg1	capabilities					168:179	the supramolecular loading capabilities	141:179	the supramolecular loading capabilities of cyclodextrins (CDs) with the optical properties of the affixed chromophores	141:258	Chromophore-appended cyclodextrins combine the supramolecular loading capabilities of cyclodextrins (CDs) with the optical properties of the affixed chromophores.
32297891	4	47	theme	turn	926:929	arg1	"					937:937	CND-based CD "turn off-on"	912:937	CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity	912:1018	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	1	48	theme	affixed	239:245	arg1	chromophores					247:258	the affixed chromophores	235:258	the affixed chromophores	235:258	Chromophore-appended cyclodextrins combine the supramolecular loading capabilities of cyclodextrins (CDs) with the optical properties of the affixed chromophores.
32297891	0	49	theme	"	82:82	arg1	sensors					89:95	competitive supramolecular "off-on" (bio)sensors	48:95	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.	0:96	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.
32297891	5	50	theme	CNDs	1098:1101	arg1	support					1129:1135	a support	1127:1135	a support for the molecular fluorophores produced during their synthesis	1127:1198	We have deconstructed the CND-CD systems to demonstrate that (i) the role of CNDs is limited to acting as a support for the molecular fluorophores produced during their synthesis and (ii) the molecular fluorophores suffice for the determination of the enzymatic activity based on the quenching by p-nitrophenol as a sacrificial quencher.
32297891	5	50	theme	CNDs	1098:1101	arg1	role					1090:1093	the role	1086:1093	the role of CNDs	1086:1101	We have deconstructed the CND-CD systems to demonstrate that (i) the role of CNDs is limited to acting as a support for the molecular fluorophores produced during their synthesis and (ii) the molecular fluorophores suffice for the determination of the enzymatic activity based on the quenching by p-nitrophenol as a sacrificial quencher.
32297891	2	51	theme	fluorescent	267:277	arg1	materials					279:287	fluorescent materials	267:287	fluorescent materials	267:287	Among fluorescent materials, carbon dots (CNDs) are attractive and the feasibility of CND-appended CDs as sensors has been demonstrated by different authors.
32297891	1	52	theme	loading	160:166	arg1	capabilities					168:179	the supramolecular loading capabilities	141:179	the supramolecular loading capabilities of cyclodextrins (CDs) with the optical properties of the affixed chromophores	141:258	Chromophore-appended cyclodextrins combine the supramolecular loading capabilities of cyclodextrins (CDs) with the optical properties of the affixed chromophores.
32297891	1	53	theme	chromophores	247:258	arg1	properties					221:230	the optical properties	209:230	the optical properties of the affixed chromophores	209:258	Chromophore-appended cyclodextrins combine the supramolecular loading capabilities of cyclodextrins (CDs) with the optical properties of the affixed chromophores.
32297891	0	54	theme	off-on	76:81	arg1	bio					85:87	bio	85:87	bio	85:87	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.
32297891	0	54	theme	off-on	76:81	arg1	"					82:82	competitive supramolecular "off-on"	48:82	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.	0:96	Carbon dots-inspired fluorescent cyclodextrins: competitive supramolecular "off-on" (bio)sensors.
32297891	5	55	dep	limited	1106:1112	arg1	i					1083:1083	i	1083:1083	i	1083:1083	We have deconstructed the CND-CD systems to demonstrate that (i) the role of CNDs is limited to acting as a support for the molecular fluorophores produced during their synthesis and (ii) the molecular fluorophores suffice for the determination of the enzymatic activity based on the quenching by p-nitrophenol as a sacrificial quencher.
32297891	5	56	theme	enzymatic	1273:1281	arg1	activity					1283:1290	the enzymatic activity	1269:1290	the enzymatic activity based on the quenching by p-nitrophenol	1269:1330	We have deconstructed the CND-CD systems to demonstrate that (i) the role of CNDs is limited to acting as a support for the molecular fluorophores produced during their synthesis and (ii) the molecular fluorophores suffice for the determination of the enzymatic activity based on the quenching by p-nitrophenol as a sacrificial quencher.
32297891	4	57	theme	5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a	645:681	arg1	paradigmatic					727:738	the most paradigmatic	718:738	the most paradigmatic of the molecular fluorophores detected in CNDs	718:785	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	57	theme	5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a	645:681	arg1	IPCA					711:714	IPCA	711:714	IPCA	711:714	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
32297891	4	57	theme	5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a	645:681	arg1	acid					705:708	5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid	645:708	5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA)	645:715	Inspired by the fluorescence properties of 5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyridine-7-carboxylic acid (IPCA), the most paradigmatic of the molecular fluorophores detected in CNDs, herein we report two highly efficient synthetic chemical strategies for the preparation of IPCA-appended CDs that behave as CND-based CD "turn off-on" biosensors suitable for the analysis of cholesterol and β-galactosidase activity.
34817202	4	0	theme	SARS-CoV-2	572:581	arg1	S					583:583	SARS-CoV-2 S	572:583	SARS-CoV-2 S	572:583	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	4	0	theme	SARS-CoV-2	572:581	arg1	proteins					598:605	N proteins	596:605	N proteins	596:605	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	4	0	theme	SARS-CoV-2	572:581	arg1	E					589:589	E	589:589	E	589:589	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	4	0	theme	SARS-CoV-2	572:581	arg1	M					586:586	M	586:586	M	586:586	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	4	1	gly	glycoproteins	623:635	arg1	glycoproteins					623:635	spike glycoproteins	617:635	spike glycoproteins that were extensively modified by complex carbohydrates	617:691	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	3	2	theme	antibody	488:495	arg1	inhibition					497:506	antibody inhibition	488:506	antibody inhibition	488:506	Approximately 35% of the SARS-CoV-2 S glycoprotein consists of carbohydrate, which can influence virus infectivity and susceptibility to antibody inhibition.
34817202	6	3	theme	solubilized	900:910	arg1	glycoproteins					914:926	soluble or solubilized S glycoproteins	889:926	soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation	889:1006	Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
34817202	14	4	theme	subunits	2270:2277	arg1	trimer					2256:2261	a trimer	2254:2261	a trimer of two subunits covered with a coat of carbohydrates (sugars)	2254:2323	The SARS-CoV-2 spike glycoprotein consists of a trimer of two subunits covered with a coat of carbohydrates (sugars).
34817202	6	5	link	N-linked	1046:1053	arg1	glycans					1055:1061	the wild-type S glycoprotein N-linked glycans	1017:1061	the wild-type S glycoprotein N-linked glycans	1017:1061	Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
34817202	13	6	theme	spike	2037:2041	arg1	target					2068:2073	the main target	2059:2073	the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines	2059:2205	The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
34817202	13	6	theme	spike	2037:2041	arg1	glycoprotein					2043:2054	The viral spike glycoprotein	2027:2054	The viral spike glycoprotein	2027:2054	The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
34817202	6	7	theme	soluble	889:895	arg1	glycoproteins					914:926	soluble or solubilized S glycoproteins	889:926	soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation	889:1006	Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
34817202	2	8	gly	glycoprotein	243:254	arg1	target					269:274	the major target	259:274	the major target for neutralizing antibodies elicited by natural infection and by vaccines	259:348	The S glycoprotein is the major target for neutralizing antibodies elicited by natural infection and by vaccines.
34817202	2	8	gly	glycoprotein	243:254	arg1	glycoprotein					243:254	The S glycoprotein	237:254	The S glycoprotein	237:254	The S glycoprotein is the major target for neutralizing antibodies elicited by natural infection and by vaccines.
34817202	1	9	gly	glycoprotein	172:183	arg1	glycoprotein					172:183	its spike (S) glycoprotein	158:183	its spike (S) glycoprotein anchored in the viral membrane	158:214	The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells.
34817202	2	10	theme	S	241:241	arg1	target					269:274	the major target	259:274	the major target for neutralizing antibodies elicited by natural infection and by vaccines	259:348	The S glycoprotein is the major target for neutralizing antibodies elicited by natural infection and by vaccines.
34817202	2	10	theme	S	241:241	arg1	glycoprotein					243:254	The S glycoprotein	237:254	The S glycoprotein	237:254	The S glycoprotein is the major target for neutralizing antibodies elicited by natural infection and by vaccines.
34817202	5	11	theme	bond	861:864	arg1	profile					866:872	its glycosylation and disulfide bond profile	829:872	profile	866:872	We used a fucose-selective lectin to purify the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer and determined its glycosylation and disulfide bond profile.
34817202	13	12	gly	glycoprotein	2043:2054	arg1	target					2068:2073	the main target	2059:2073	the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines	2059:2205	The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
34817202	13	12	gly	glycoprotein	2043:2054	arg1	glycoprotein					2043:2054	The viral spike glycoprotein	2027:2054	The viral spike glycoprotein	2027:2054	The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
34817202	16	13	theme	bond	2648:2651	arg1	formation					2653:2661	disulfide bond formation	2638:2661	disulfide bond formation	2638:2661	We also evaluate the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation.
34817202	4	14	theme	N	596:596	arg1	proteins					598:605	N proteins	596:605	N proteins	596:605	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	4	14	theme	N	596:596	arg1	S					583:583	SARS-CoV-2 S	572:583	SARS-CoV-2 S	572:583	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	10	15	theme	natural	1654:1660	arg1	variants					1671:1678	other natural cysteine variants	1648:1678	other natural cysteine variants	1648:1678	Unlike other natural cysteine variants, a Cys15Phe (C15F) mutant retained partial, but unstable, infectivity.
34817202	11	16	theme	glycoprotein	1843:1854	arg1	processing					1805:1814	the Golgi processing	1795:1814	the Golgi processing of the native SARS-CoV-2 S glycoprotein	1795:1854	These findings enhance our understanding of the Golgi processing of the native SARS-CoV-2 S glycoprotein carbohydrates and could assist the design of interventions.
34817202	2	17	theme	major	263:267	arg1	target					269:274	the major target	259:274	the major target for neutralizing antibodies elicited by natural infection and by vaccines	259:348	The S glycoprotein is the major target for neutralizing antibodies elicited by natural infection and by vaccines.
34817202	2	17	theme	major	263:267	arg1	glycoprotein					243:254	The S glycoprotein	237:254	The S glycoprotein	237:254	The S glycoprotein is the major target for neutralizing antibodies elicited by natural infection and by vaccines.
34817202	5	18	used	used	697:700	arg2	We					694:695	We	694:695	We	694:695	We used a fucose-selective lectin to purify the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer and determined its glycosylation and disulfide bond profile.
34817202	1	19	theme	etiologic	124:132	arg1	agent					134:138	the etiologic agent	120:138	the etiologic agent of COVID-19	120:150	The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells.
34817202	1	19	theme	etiologic	124:132	arg1	coronavirus					107:117	The SARS-CoV-2 coronavirus	92:117	The SARS-CoV-2 coronavirus	92:117	The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells.
34817202	17	20	theme	vaccines	2713:2720	arg1	improvement					2698:2708	the improvement	2694:2708	the improvement of vaccines and therapies for COVID-19	2694:2747	This information can expedite the improvement of vaccines and therapies for COVID-19.
34817202	14	21	theme	spike	2223:2227	arg1	glycoprotein					2229:2240	The SARS-CoV-2 spike glycoprotein	2208:2240	The SARS-CoV-2 spike glycoprotein	2208:2240	The SARS-CoV-2 spike glycoprotein consists of a trimer of two subunits covered with a coat of carbohydrates (sugars).
34817202	6	22	theme	proteolytic	948:958	arg1	cleavage					960:967	proteolytic cleavage	948:967	proteolytic cleavage	948:967	Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
34817202	17	23	theme	therapies	2726:2734	arg1	improvement					2698:2708	the improvement	2694:2708	the improvement of vaccines and therapies for COVID-19	2694:2747	This information can expedite the improvement of vaccines and therapies for COVID-19.
34817202	9	24	theme	soluble	1559:1565	arg1	ACE2					1567:1570	soluble ACE2	1559:1570	soluble ACE2	1559:1570	Viruses pseudotyped with natural variants of the serine/threonine residues implicated in O-linked glycosylation were generally infectious and exhibited sensitivity to neutralization by soluble ACE2 and convalescent antisera comparable to that of the wild-type virus.
34817202	8	25	theme	occupied	1318:1325	arg1	sites					1327:1331	Three incompletely occupied sites	1299:1331	Three incompletely occupied sites of O-linked glycosylation	1299:1357	Three incompletely occupied sites of O-linked glycosylation were detected.
34817202	8	25	theme	occupied	1318:1325	arg1	glycosylation					1345:1357	O-linked glycosylation	1336:1357	O-linked glycosylation	1336:1357	Three incompletely occupied sites of O-linked glycosylation were detected.
34817202	11	26	theme	processing	1805:1814	arg1	understanding					1778:1790	our understanding	1774:1790	our understanding of the Golgi processing of the native SARS-CoV-2 S glycoprotein	1774:1854	These findings enhance our understanding of the Golgi processing of the native SARS-CoV-2 S glycoprotein carbohydrates and could assist the design of interventions.
34817202	15	27	theme	spike	2391:2395	arg1	glycoprotein					2397:2408	the SARS-CoV-2 spike glycoprotein	2376:2408	the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface	2376:2506	Here, we describe the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface.
34817202	6	28	theme	wild-type	1021:1029	arg1	glycans					1055:1061	the wild-type S glycoprotein N-linked glycans	1017:1061	the wild-type S glycoprotein N-linked glycans	1017:1061	Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
34817202	0	29	theme	SARS-CoV-2	61:70	arg1	Glycoprotein					78:89	Wild-Type SARS-CoV-2 Spike Glycoprotein	51:89	Wild-Type SARS-CoV-2 Spike Glycoprotein	51:89	Analysis of Glycosylation and Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein.
34817202	13	30	theme	SARS-CoV-2	2128:2137	arg1	infection					2139:2147	SARS-CoV-2 infection	2128:2147	SARS-CoV-2 infection	2128:2147	The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
34817202	0	31	theme	Glycosylation	12:24	arg1	Bonding					40:46	Disulfide Bonding	30:46	Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein	30:89	Analysis of Glycosylation and Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein.
34817202	0	31	theme	Glycosylation	12:24	arg1	Analysis					0:7	Analysis	0:7	Analysis of Glycosylation	0:24	Analysis of Glycosylation and Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein.
34817202	15	32	theme	glycoprotein	2487:2498	arg1	surface					2500:2506	the glycoprotein surface	2483:2506	the glycoprotein surface	2483:2506	Here, we describe the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface.
34817202	4	33	theme	complex	671:677	arg1	carbohydrates					679:691	complex carbohydrates	671:691	complex carbohydrates	671:691	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	11	34	theme	SARS-CoV-2	1830:1839	arg1	glycoprotein					1843:1854	the native SARS-CoV-2 S glycoprotein	1819:1854	the native SARS-CoV-2 S glycoprotein	1819:1854	These findings enhance our understanding of the Golgi processing of the native SARS-CoV-2 S glycoprotein carbohydrates and could assist the design of interventions.
34817202	0	35	theme	Glycoprotein	78:89	arg1	Bonding					40:46	Disulfide Bonding	30:46	Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein	30:89	Analysis of Glycosylation and Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein.
34817202	0	35	theme	Glycoprotein	78:89	arg1	Analysis					0:7	Analysis	0:7	Analysis of Glycosylation	0:24	Analysis of Glycosylation and Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein.
34817202	15	36	theme	sugar	2465:2469	arg1	moieties					2471:2478	the sugar moieties	2461:2478	the sugar moieties	2461:2478	Here, we describe the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface.
34817202	5	37	theme	fucose-selective	704:719	arg1	lectin					721:726	a fucose-selective lectin	702:726	a fucose-selective lectin	702:726	We used a fucose-selective lectin to purify the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer and determined its glycosylation and disulfide bond profile.
34817202	6	38	theme	prefusion	985:993	arg1	conformation					995:1006	a prefusion conformation	983:1006	a prefusion conformation	983:1006	Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
34817202	15	39	from	shape	2432:2436	arg1	surface					2500:2506	the glycoprotein surface	2483:2506	the glycoprotein surface	2483:2506	Here, we describe the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface.
34817202	10	40	theme	partial	1715:1721	arg1	infectivity					1738:1748	partial, but unstable, infectivity	1715:1748	partial, but unstable, infectivity	1715:1748	Unlike other natural cysteine variants, a Cys15Phe (C15F) mutant retained partial, but unstable, infectivity.
34817202	7	41	theme	characterized	1189:1201	arg1	preparations					1212:1223	other characterized S trimer preparations	1183:1223	other characterized S trimer preparations	1183:1223	Even Asn 234, a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations, is predominantly modified in the Golgi compartment by processed glycans.
34817202	9	42	theme	wild-type	1624:1632	arg1	virus					1634:1638	the wild-type virus	1620:1638	the wild-type virus	1620:1638	Viruses pseudotyped with natural variants of the serine/threonine residues implicated in O-linked glycosylation were generally infectious and exhibited sensitivity to neutralization by soluble ACE2 and convalescent antisera comparable to that of the wild-type virus.
34817202	14	43	theme	SARS-CoV-2	2212:2221	arg1	glycoprotein					2229:2240	The SARS-CoV-2 spike glycoprotein	2208:2240	The SARS-CoV-2 spike glycoprotein	2208:2240	The SARS-CoV-2 spike glycoprotein consists of a trimer of two subunits covered with a coat of carbohydrates (sugars).
34817202	6	44	theme	complex	1080:1086	arg1	forms					1088:1092	complex forms	1080:1092	complex forms	1080:1092	Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
34817202	16	45	from	variation	2560:2568	arg1	addition					2588:2595	O-linked sugar addition	2573:2595	O-linked sugar addition	2573:2595	We also evaluate the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation.
34817202	8	46	link	O-linked	1336:1343	arg1	glycosylation					1345:1357	O-linked glycosylation	1336:1357	O-linked glycosylation	1336:1357	Three incompletely occupied sites of O-linked glycosylation were detected.
34817202	3	47	theme	glycoprotein	389:400	arg1	glycoprotein					389:400	the SARS-CoV-2 S glycoprotein	372:400	the SARS-CoV-2 S glycoprotein	372:400	Approximately 35% of the SARS-CoV-2 S glycoprotein consists of carbohydrate, which can influence virus infectivity and susceptibility to antibody inhibition.
34817202	3	47	theme	glycoprotein	389:400	arg1	%					367:367	Approximately 35%	351:367	Approximately 35% of the SARS-CoV-2 S glycoprotein	351:400	Approximately 35% of the SARS-CoV-2 S glycoprotein consists of carbohydrate, which can influence virus infectivity and susceptibility to antibody inhibition.
34817202	5	48	theme	glycoprotein	794:805	arg1	trimer					807:812	a wild-type SARS-CoV-2 S glycoprotein trimer	769:812	a wild-type SARS-CoV-2 S glycoprotein trimer	769:812	We used a fucose-selective lectin to purify the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer and determined its glycosylation and disulfide bond profile.
34817202	15	49	theme	disulfide	2348:2356	arg1	bonds					2358:2362	the disulfide bonds	2344:2362	the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface	2344:2506	Here, we describe the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface.
34817202	1	50	theme	SARS-CoV-2	96:105	arg1	agent					134:138	the etiologic agent	120:138	the etiologic agent of COVID-19	120:150	The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells.
34817202	1	50	theme	SARS-CoV-2	96:105	arg1	coronavirus					107:117	The SARS-CoV-2 coronavirus	92:117	The SARS-CoV-2 coronavirus	92:117	The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells.
34817202	7	51	theme	high-mannose	1159:1170	arg1	glycans					1172:1178	high-mannose glycans	1159:1178	high-mannose glycans on other characterized S trimer preparations	1159:1223	Even Asn 234, a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations, is predominantly modified in the Golgi compartment by processed glycans.
34817202	12	52	theme	SARS-CoV-2	1931:1940	arg1	coronavirus					1942:1952	The SARS-CoV-2 coronavirus	1927:1952	The SARS-CoV-2 coronavirus	1927:1952	IMPORTANCE The SARS-CoV-2 coronavirus, which causes COVID-19, uses its spike glycoprotein to enter host cells.
34817202	16	53	theme	natural	2546:2552	arg1	variation					2560:2568	natural virus variation	2546:2568	natural virus variation in O-linked sugar addition	2546:2595	We also evaluate the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation.
34817202	1	54	theme	COVID-19	143:150	arg1	agent					134:138	the etiologic agent	120:138	the etiologic agent of COVID-19	120:150	The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells.
34817202	1	54	theme	COVID-19	143:150	arg1	coronavirus					107:117	The SARS-CoV-2 coronavirus	92:117	The SARS-CoV-2 coronavirus	92:117	The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells.
34817202	3	55	theme	SARS-CoV-2	376:385	arg1	glycoprotein					389:400	the SARS-CoV-2 S glycoprotein	372:400	the SARS-CoV-2 S glycoprotein	372:400	Approximately 35% of the SARS-CoV-2 S glycoprotein consists of carbohydrate, which can influence virus infectivity and susceptibility to antibody inhibition.
34817202	15	56	gly	glycoprotein	2487:2498	arg1	glycoprotein					2487:2498	the glycoprotein surface	2483:2506	the glycoprotein surface	2483:2506	Here, we describe the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface.
34817202	6	57	gly	glycoprotein	1033:1044	arg1	glycoprotein					1033:1044	the wild-type S glycoprotein N-linked glycans	1017:1061	the wild-type S glycoprotein N-linked glycans	1017:1061	Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
34817202	4	58	contain	contained	607:615	arg2	glycoproteins					623:635	spike glycoproteins	617:635	spike glycoproteins that were extensively modified by complex carbohydrates	617:691	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	4	58	contain	contained	607:615	arg1	particles					534:542	virus-like particles	523:542	virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins	523:605	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	5	59	gly	glycoprotein	794:805	arg1	glycoprotein					794:805	a wild-type SARS-CoV-2 S glycoprotein trimer	769:812	a wild-type SARS-CoV-2 S glycoprotein trimer	769:812	We used a fucose-selective lectin to purify the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer and determined its glycosylation and disulfide bond profile.
34817202	14	60	theme	carbohydrates	2302:2314	arg1	coat					2294:2297	a coat	2292:2297	a coat of carbohydrates (sugars)	2292:2323	The SARS-CoV-2 spike glycoprotein consists of a trimer of two subunits covered with a coat of carbohydrates (sugars).
34817202	5	61	theme	disulfide	851:859	arg1	profile					866:872	its glycosylation and disulfide bond profile	829:872	profile	866:872	We used a fucose-selective lectin to purify the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer and determined its glycosylation and disulfide bond profile.
34817202	0	62	theme	Disulfide	30:38	arg1	Bonding					40:46	Disulfide Bonding	30:46	Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein	30:89	Analysis of Glycosylation and Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein.
34817202	16	63	theme	variation	2560:2568	arg1	consequences					2530:2541	the consequences	2526:2541	the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation	2526:2661	We also evaluate the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation.
34817202	6	64	theme	glycoprotein	1033:1044	arg1	glycans					1055:1061	the wild-type S glycoprotein N-linked glycans	1017:1061	the wild-type S glycoprotein N-linked glycans	1017:1061	Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
34817202	13	65	theme	host	2078:2081	arg1	antibodies					2096:2105	host neutralizing antibodies	2078:2105	host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines	2078:2205	The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
34817202	2	66	theme	natural	316:322	arg1	infection					324:332	natural infection	316:332	natural infection	316:332	The S glycoprotein is the major target for neutralizing antibodies elicited by natural infection and by vaccines.
34817202	5	67	theme	SARS-CoV-2	781:790	arg1	trimer					807:812	a wild-type SARS-CoV-2 S glycoprotein trimer	769:812	a wild-type SARS-CoV-2 S glycoprotein trimer	769:812	We used a fucose-selective lectin to purify the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer and determined its glycosylation and disulfide bond profile.
34817202	9	68	theme	natural	1399:1405	arg1	variants					1407:1414	natural variants	1399:1414	natural variants of the serine/threonine residues implicated in O-linked glycosylation	1399:1484	Viruses pseudotyped with natural variants of the serine/threonine residues implicated in O-linked glycosylation were generally infectious and exhibited sensitivity to neutralization by soluble ACE2 and convalescent antisera comparable to that of the wild-type virus.
34817202	16	69	theme	O-linked	2573:2580	arg1	addition					2588:2595	O-linked sugar addition	2573:2595	O-linked sugar addition	2573:2595	We also evaluate the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation.
34817202	13	70	theme	antibodies	2096:2105	arg1	target					2068:2073	the main target	2059:2073	the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines	2059:2205	The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
34817202	13	70	theme	antibodies	2096:2105	arg1	glycoprotein					2043:2054	The viral spike glycoprotein	2027:2054	The viral spike glycoprotein	2027:2054	The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
34817202	3	71	theme	virus	448:452	arg1	infectivity					454:464	virus infectivity	448:464	virus infectivity	448:464	Approximately 35% of the SARS-CoV-2 S glycoprotein consists of carbohydrate, which can influence virus infectivity and susceptibility to antibody inhibition.
34817202	1	72	theme	viral	201:205	arg1	membrane					207:214	the viral membrane	197:214	the viral membrane	197:214	The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells.
34817202	16	73	link	O-linked	2573:2580	arg1	addition					2588:2595	O-linked sugar addition	2573:2595	O-linked sugar addition	2573:2595	We also evaluate the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation.
34817202	15	74	gly	glycoprotein	2397:2408	arg1	glycoprotein					2397:2408	the SARS-CoV-2 spike glycoprotein	2376:2408	the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface	2376:2506	Here, we describe the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface.
34817202	7	75	mod	modified	1243:1250	arg1	Asn					1100:1102	Asn 234	1100:1106	Even Asn 234	1095:1106	Even Asn 234, a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations, is predominantly modified in the Golgi compartment by processed glycans.
34817202	7	75	mod	modified	1243:1250	arg3	glycans					1290:1296	processed glycans	1280:1296	processed glycans	1280:1296	Even Asn 234, a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations, is predominantly modified in the Golgi compartment by processed glycans.
34817202	7	75	mod	modified	1243:1250	arg1	percentage					1123:1132	a significant percentage	1109:1132	a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations	1109:1223	Even Asn 234, a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations, is predominantly modified in the Golgi compartment by processed glycans.
34817202	9	76	theme	serine/threonine	1423:1438	arg1	residues					1440:1447	the serine/threonine residues	1419:1447	the serine/threonine residues implicated in O-linked glycosylation	1419:1484	Viruses pseudotyped with natural variants of the serine/threonine residues implicated in O-linked glycosylation were generally infectious and exhibited sensitivity to neutralization by soluble ACE2 and convalescent antisera comparable to that of the wild-type virus.
34817202	0	77	theme	Wild-Type	51:59	arg1	Glycoprotein					78:89	Wild-Type SARS-CoV-2 Spike Glycoprotein	51:89	Wild-Type SARS-CoV-2 Spike Glycoprotein	51:89	Analysis of Glycosylation and Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein.
34817202	11	78	theme	Golgi	1799:1803	arg1	processing					1805:1814	the Golgi processing	1795:1814	the Golgi processing of the native SARS-CoV-2 S glycoprotein	1795:1854	These findings enhance our understanding of the Golgi processing of the native SARS-CoV-2 S glycoprotein carbohydrates and could assist the design of interventions.
34817202	7	79	theme	Golgi	1259:1263	arg1	compartment					1265:1275	the Golgi compartment	1255:1275	the Golgi compartment	1255:1275	Even Asn 234, a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations, is predominantly modified in the Golgi compartment by processed glycans.
34817202	7	80	theme	significant	1111:1121	arg1	Asn					1100:1102	Asn 234	1100:1106	Even Asn 234	1095:1106	Even Asn 234, a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations, is predominantly modified in the Golgi compartment by processed glycans.
34817202	7	80	theme	significant	1111:1121	arg1	percentage					1123:1132	a significant percentage	1109:1132	a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations	1109:1223	Even Asn 234, a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations, is predominantly modified in the Golgi compartment by processed glycans.
34817202	1	81	theme	host	225:228	arg1	cells					230:234	host cells	225:234	host cells	225:234	The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells.
34817202	6	82	theme	S	912:912	arg1	glycoproteins					914:926	soluble or solubilized S glycoproteins	889:926	soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation	889:1006	Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
34817202	9	83	link	O-linked	1463:1470	arg1	glycosylation					1472:1484	O-linked glycosylation	1463:1484	O-linked glycosylation	1463:1484	Viruses pseudotyped with natural variants of the serine/threonine residues implicated in O-linked glycosylation were generally infectious and exhibited sensitivity to neutralization by soluble ACE2 and convalescent antisera comparable to that of the wild-type virus.
34817202	10	84	theme	other	1648:1652	arg1	variants					1671:1678	other natural cysteine variants	1648:1678	other natural cysteine variants	1648:1678	Unlike other natural cysteine variants, a Cys15Phe (C15F) mutant retained partial, but unstable, infectivity.
34817202	13	85	theme	viral	2031:2035	arg1	target					2068:2073	the main target	2059:2073	the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines	2059:2205	The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
34817202	13	85	theme	viral	2031:2035	arg1	glycoprotein					2043:2054	The viral spike glycoprotein	2027:2054	The viral spike glycoprotein	2027:2054	The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
34817202	9	86	theme	O-linked	1463:1470	arg1	glycosylation					1472:1484	O-linked glycosylation	1463:1484	O-linked glycosylation	1463:1484	Viruses pseudotyped with natural variants of the serine/threonine residues implicated in O-linked glycosylation were generally infectious and exhibited sensitivity to neutralization by soluble ACE2 and convalescent antisera comparable to that of the wild-type virus.
34817202	8	87	theme	glycosylation	1345:1357	arg1	sites					1327:1331	Three incompletely occupied sites	1299:1331	Three incompletely occupied sites of O-linked glycosylation	1299:1357	Three incompletely occupied sites of O-linked glycosylation were detected.
34817202	8	87	theme	glycosylation	1345:1357	arg1	glycosylation					1345:1357	O-linked glycosylation	1336:1357	O-linked glycosylation	1336:1357	Three incompletely occupied sites of O-linked glycosylation were detected.
34817202	4	88	theme	S	583:583	arg1	coexpression					556:567	coexpression	556:567	coexpression of SARS-CoV-2 S, M, E, and N proteins	556:605	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	1	89	theme	spike	162:166	arg1	glycoprotein					172:183	its spike (S) glycoprotein	158:183	its spike (S) glycoprotein anchored in the viral membrane	158:214	The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells.
34817202	4	90	theme	spike	617:621	arg1	glycoproteins					623:635	spike glycoproteins	617:635	spike glycoproteins that were extensively modified by complex carbohydrates	617:691	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	1	91	theme	S	169:169	arg1	glycoprotein					172:183	its spike (S) glycoprotein	158:183	its spike (S) glycoprotein anchored in the viral membrane	158:214	The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells.
34817202	10	92	theme	cysteine	1662:1669	arg1	variants					1671:1678	other natural cysteine variants	1648:1678	other natural cysteine variants	1648:1678	Unlike other natural cysteine variants, a Cys15Phe (C15F) mutant retained partial, but unstable, infectivity.
34817202	10	93	theme	C15F	1693:1696	arg1	mutant					1699:1704	a Cys15Phe (C15F) mutant	1681:1704	a Cys15Phe (C15F) mutant	1681:1704	Unlike other natural cysteine variants, a Cys15Phe (C15F) mutant retained partial, but unstable, infectivity.
34817202	10	94	theme	Cys15Phe	1683:1690	arg1	mutant					1699:1704	a Cys15Phe (C15F) mutant	1681:1704	a Cys15Phe (C15F) mutant	1681:1704	Unlike other natural cysteine variants, a Cys15Phe (C15F) mutant retained partial, but unstable, infectivity.
34817202	16	95	from	addition	2588:2595	arg1	consequences					2530:2541	the consequences	2526:2541	the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation	2526:2661	We also evaluate the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation.
34817202	15	96	theme	correct	2424:2430	arg1	shape					2432:2436	the correct shape	2420:2436	the correct shape	2420:2436	Here, we describe the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface.
34817202	6	97	theme	S	1031:1031	arg1	glycans					1055:1061	the wild-type S glycoprotein N-linked glycans	1017:1061	the wild-type S glycoprotein N-linked glycans	1017:1061	Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
34817202	12	98	gly	glycoprotein	1993:2004	arg1	glycoprotein					1993:2004	its spike glycoprotein	1983:2004	its spike glycoprotein	1983:2004	IMPORTANCE The SARS-CoV-2 coronavirus, which causes COVID-19, uses its spike glycoprotein to enter host cells.
34817202	11	99	theme	interventions	1901:1913	arg1	design					1891:1896	the design	1887:1896	the design of interventions	1887:1913	These findings enhance our understanding of the Golgi processing of the native SARS-CoV-2 S glycoprotein carbohydrates and could assist the design of interventions.
34817202	0	100	theme	Spike	72:76	arg1	Glycoprotein					78:89	Wild-Type SARS-CoV-2 Spike Glycoprotein	51:89	Wild-Type SARS-CoV-2 Spike Glycoprotein	51:89	Analysis of Glycosylation and Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein.
34817202	9	101	theme	convalescent	1576:1587	arg1	antisera					1589:1596	convalescent antisera	1576:1596	convalescent antisera comparable to that of the wild-type virus	1576:1638	Viruses pseudotyped with natural variants of the serine/threonine residues implicated in O-linked glycosylation were generally infectious and exhibited sensitivity to neutralization by soluble ACE2 and convalescent antisera comparable to that of the wild-type virus.
34817202	16	102	theme	cysteine	2608:2615	arg1	residues					2617:2624	the cysteine residues	2604:2624	the cysteine residues involved in disulfide bond formation	2604:2661	We also evaluate the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation.
34817202	6	103	gly	glycoproteins	914:926	arg1	glycoproteins					914:926	soluble or solubilized S glycoproteins	889:926	soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation	889:1006	Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
34817202	7	104	theme	trimer	1205:1210	arg1	preparations					1212:1223	other characterized S trimer preparations	1183:1223	other characterized S trimer preparations	1183:1223	Even Asn 234, a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations, is predominantly modified in the Golgi compartment by processed glycans.
34817202	5	105	theme	Golgi-modified	742:755	arg1	fraction					757:764	the Golgi-modified fraction	738:764	the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer	738:812	We used a fucose-selective lectin to purify the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer and determined its glycosylation and disulfide bond profile.
34817202	12	106	theme	spike	1987:1991	arg1	glycoprotein					1993:2004	its spike glycoprotein	1983:2004	its spike glycoprotein	1983:2004	IMPORTANCE The SARS-CoV-2 coronavirus, which causes COVID-19, uses its spike glycoprotein to enter host cells.
34817202	9	107	theme	comparable	1598:1607	arg1	antisera					1589:1596	convalescent antisera	1576:1596	convalescent antisera comparable to that of the wild-type virus	1576:1638	Viruses pseudotyped with natural variants of the serine/threonine residues implicated in O-linked glycosylation were generally infectious and exhibited sensitivity to neutralization by soluble ACE2 and convalescent antisera comparable to that of the wild-type virus.
34817202	8	108	theme	O-linked	1336:1343	arg1	glycosylation					1345:1357	O-linked glycosylation	1336:1357	O-linked glycosylation	1336:1357	Three incompletely occupied sites of O-linked glycosylation were detected.
34817202	11	109	theme	S	1841:1841	arg1	glycoprotein					1843:1854	the native SARS-CoV-2 S glycoprotein	1819:1854	the native SARS-CoV-2 S glycoprotein	1819:1854	These findings enhance our understanding of the Golgi processing of the native SARS-CoV-2 S glycoprotein carbohydrates and could assist the design of interventions.
34817202	7	110	theme	S	1203:1203	arg1	preparations					1212:1223	other characterized S trimer preparations	1183:1223	other characterized S trimer preparations	1183:1223	Even Asn 234, a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations, is predominantly modified in the Golgi compartment by processed glycans.
34817202	15	111	theme	moieties	2471:2478	arg1	shape					2432:2436	the correct shape	2420:2436	the correct shape	2420:2436	Here, we describe the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface.
34817202	15	111	theme	moieties	2471:2478	arg1	composition					2446:2456	the composition	2442:2456	the composition of the sugar moieties on the glycoprotein surface	2442:2506	Here, we describe the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface.
34817202	16	112	theme	disulfide	2638:2646	arg1	formation					2653:2661	disulfide bond formation	2638:2661	disulfide bond formation	2638:2661	We also evaluate the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation.
34817202	11	113	theme	native	1823:1828	arg1	glycoprotein					1843:1854	the native SARS-CoV-2 S glycoprotein	1819:1854	the native SARS-CoV-2 S glycoprotein	1819:1854	These findings enhance our understanding of the Golgi processing of the native SARS-CoV-2 S glycoprotein carbohydrates and could assist the design of interventions.
34817202	7	114	theme	other	1183:1187	arg1	preparations					1212:1223	other characterized S trimer preparations	1183:1223	other characterized S trimer preparations	1183:1223	Even Asn 234, a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations, is predominantly modified in the Golgi compartment by processed glycans.
34817202	7	115	from	glycans	1172:1178	arg1	preparations					1212:1223	other characterized S trimer preparations	1183:1223	other characterized S trimer preparations	1183:1223	Even Asn 234, a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations, is predominantly modified in the Golgi compartment by processed glycans.
34817202	12	116	theme	host	2015:2018	arg1	cells					2020:2024	host cells	2015:2024	host cells	2015:2024	IMPORTANCE The SARS-CoV-2 coronavirus, which causes COVID-19, uses its spike glycoprotein to enter host cells.
34817202	5	117	theme	S	792:792	arg1	trimer					807:812	a wild-type SARS-CoV-2 S glycoprotein trimer	769:812	a wild-type SARS-CoV-2 S glycoprotein trimer	769:812	We used a fucose-selective lectin to purify the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer and determined its glycosylation and disulfide bond profile.
34817202	8	118	gly	glycosylation	1345:1357	arg2	glycosylation					1345:1357	O-linked glycosylation	1336:1357	O-linked glycosylation	1336:1357	Three incompletely occupied sites of O-linked glycosylation were detected.
34817202	8	118	gly	glycosylation	1345:1357	arg2	sites					1327:1331	Three incompletely occupied sites	1299:1331	Three incompletely occupied sites of O-linked glycosylation	1299:1357	Three incompletely occupied sites of O-linked glycosylation were detected.
34817202	15	119	from	composition	2446:2456	arg1	surface					2500:2506	the glycoprotein surface	2483:2506	the glycoprotein surface	2483:2506	Here, we describe the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface.
34817202	5	120	theme	trimer	807:812	arg1	fraction					757:764	the Golgi-modified fraction	738:764	the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer	738:812	We used a fucose-selective lectin to purify the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer and determined its glycosylation and disulfide bond profile.
34817202	10	121	theme	unstable	1728:1735	arg1	infectivity					1738:1748	partial, but unstable, infectivity	1715:1748	partial, but unstable, infectivity	1715:1748	Unlike other natural cysteine variants, a Cys15Phe (C15F) mutant retained partial, but unstable, infectivity.
34817202	16	122	from	consequences	2530:2541	arg1	residues					2617:2624	the cysteine residues	2604:2624	the cysteine residues involved in disulfide bond formation	2604:2661	We also evaluate the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation.
34817202	16	122	from	consequences	2530:2541	arg1	addition					2588:2595	O-linked sugar addition	2573:2595	O-linked sugar addition	2573:2595	We also evaluate the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation.
34817202	4	123	mod	modified	659:666	arg1	glycoproteins					623:635	spike glycoproteins	617:635	spike glycoproteins that were extensively modified by complex carbohydrates	617:691	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	4	123	mod	modified	659:666	arg3	carbohydrates					679:691	complex carbohydrates	671:691	complex carbohydrates	671:691	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	6	124	theme	N-linked	1046:1053	arg1	glycans					1055:1061	the wild-type S glycoprotein N-linked glycans	1017:1061	the wild-type S glycoprotein N-linked glycans	1017:1061	Compared with soluble or solubilized S glycoproteins modified to prevent proteolytic cleavage and to retain a prefusion conformation, more of the wild-type S glycoprotein N-linked glycans are processed to complex forms.
34817202	3	125	theme	S	387:387	arg1	glycoprotein					389:400	the SARS-CoV-2 S glycoprotein	372:400	the SARS-CoV-2 S glycoprotein	372:400	Approximately 35% of the SARS-CoV-2 S glycoprotein consists of carbohydrate, which can influence virus infectivity and susceptibility to antibody inhibition.
34817202	5	126	theme	wild-type	771:779	arg1	trimer					807:812	a wild-type SARS-CoV-2 S glycoprotein trimer	769:812	a wild-type SARS-CoV-2 S glycoprotein trimer	769:812	We used a fucose-selective lectin to purify the Golgi-modified fraction of a wild-type SARS-CoV-2 S glycoprotein trimer and determined its glycosylation and disulfide bond profile.
34817202	16	127	theme	virus	2554:2558	arg1	variation					2560:2568	natural virus variation	2546:2568	natural virus variation in O-linked sugar addition	2546:2595	We also evaluate the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation.
34817202	7	128	theme	processed	1280:1288	arg1	glycans					1290:1296	processed glycans	1280:1296	processed glycans	1280:1296	Even Asn 234, a significant percentage of which is decorated by high-mannose glycans on other characterized S trimer preparations, is predominantly modified in the Golgi compartment by processed glycans.
34817202	4	129	theme	virus-like	523:532	arg1	particles					534:542	virus-like particles	523:542	virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins	523:605	We found that virus-like particles produced by coexpression of SARS-CoV-2 S, M, E, and N proteins contained spike glycoproteins that were extensively modified by complex carbohydrates.
34817202	13	130	theme	neutralizing	2083:2094	arg1	antibodies					2096:2105	host neutralizing antibodies	2078:2105	host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines	2078:2205	The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
34817202	11	131	gly	glycoprotein	1843:1854	arg1	glycoprotein					1843:1854	the native SARS-CoV-2 S glycoprotein	1819:1854	the native SARS-CoV-2 S glycoprotein	1819:1854	These findings enhance our understanding of the Golgi processing of the native SARS-CoV-2 S glycoprotein carbohydrates and could assist the design of interventions.
34817202	15	132	theme	SARS-CoV-2	2380:2389	arg1	glycoprotein					2397:2408	the SARS-CoV-2 spike glycoprotein	2376:2408	the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface	2376:2506	Here, we describe the disulfide bonds that assist the SARS-CoV-2 spike glycoprotein to assume the correct shape and the composition of the sugar moieties on the glycoprotein surface.
34817202	16	133	theme	sugar	2582:2586	arg1	addition					2588:2595	O-linked sugar addition	2573:2595	O-linked sugar addition	2573:2595	We also evaluate the consequences of natural virus variation in O-linked sugar addition and in the cysteine residues involved in disulfide bond formation.
34817202	14	134	gly	glycoprotein	2229:2240	arg1	glycoprotein					2229:2240	The SARS-CoV-2 spike glycoprotein	2208:2240	The SARS-CoV-2 spike glycoprotein	2208:2240	The SARS-CoV-2 spike glycoprotein consists of a trimer of two subunits covered with a coat of carbohydrates (sugars).
34817202	12	135	dep	IMPORTANCE	1916:1925	arg1	coronavirus					1942:1952	The SARS-CoV-2 coronavirus	1927:1952	The SARS-CoV-2 coronavirus	1927:1952	IMPORTANCE The SARS-CoV-2 coronavirus, which causes COVID-19, uses its spike glycoprotein to enter host cells.
34817202	3	136	gly	glycoprotein	389:400	arg1	glycoprotein					389:400	the SARS-CoV-2 S glycoprotein	372:400	the SARS-CoV-2 S glycoprotein	372:400	Approximately 35% of the SARS-CoV-2 S glycoprotein consists of carbohydrate, which can influence virus infectivity and susceptibility to antibody inhibition.
34817202	13	137	theme	main	2063:2066	arg1	target					2068:2073	the main target	2059:2073	the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines	2059:2205	The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
34817202	13	137	theme	main	2063:2066	arg1	glycoprotein					2043:2054	The viral spike glycoprotein	2027:2054	The viral spike glycoprotein	2027:2054	The viral spike glycoprotein is the main target of host neutralizing antibodies that help to control SARS-CoV-2 infection and are important for the protection provided by vaccines.
34817202	9	138	theme	residues	1440:1447	arg1	variants					1407:1414	natural variants	1399:1414	natural variants of the serine/threonine residues implicated in O-linked glycosylation	1399:1484	Viruses pseudotyped with natural variants of the serine/threonine residues implicated in O-linked glycosylation were generally infectious and exhibited sensitivity to neutralization by soluble ACE2 and convalescent antisera comparable to that of the wild-type virus.
32806276	0	0	theme	cross-linked	73:84	arg1	hydrogels					86:94	physically cross-linked hydrogels	62:94	physically cross-linked hydrogels	62:94	Synthesis of an un-modified gum arabic and acrylic acid based physically cross-linked hydrogels with high mechanical, self-sustainable and self-healable performance.
32806276	7	1	theme	percent	1067:1073	arg1	recovery					1075:1082	the percent recovery	1063:1082	the percent recovery in	1063:1085	After 4 min of resting time, the percent recovery in dissipated energy reaching a high value of 95%, indicating the excellent fatigue resistance performance of the hydrogels.
32806276	7	2	theme	resting	1049:1055	arg1	time					1057:1060	resting time	1049:1060	resting time	1049:1060	After 4 min of resting time, the percent recovery in dissipated energy reaching a high value of 95%, indicating the excellent fatigue resistance performance of the hydrogels.
32806276	1	3	theme	arabic	246:251	arg1	synthesis					215:223	the synthesis	211:223	the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA)	211:278	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	8	4	contain	contain	1223:1229	arg2	%					1234:1234	3-5%	1231:1234	3-5% of water	1231:1243	The hydrogels contain 3-5% of water at normal conditions and confirm its environmental stability.
32806276	8	4	contain	contain	1223:1229	arg2	water					1239:1243	water	1239:1243	water	1239:1243	The hydrogels contain 3-5% of water at normal conditions and confirm its environmental stability.
32806276	8	4	contain	contain	1223:1229	arg1	conditions					1255:1264	normal conditions	1248:1264	normal conditions	1248:1264	The hydrogels contain 3-5% of water at normal conditions and confirm its environmental stability.
32806276	8	4	contain	contain	1223:1229	arg1	hydrogels					1213:1221	The hydrogels	1209:1221	The hydrogels	1209:1221	The hydrogels contain 3-5% of water at normal conditions and confirm its environmental stability.
32806276	8	4	contain	contain	1223:1229	arg2	hydrogels					1213:1221	The hydrogels	1209:1221	The hydrogels	1209:1221	The hydrogels contain 3-5% of water at normal conditions and confirm its environmental stability.
32806276	1	5	theme	novel	168:172	arg1	strategy					185:192	A novel and simple strategy	166:192	A novel and simple strategy	166:192	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	9	6	theme	unmodified	1363:1372	arg1	systems					1425:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	This work provides a new direction for the synthesis of unmodified GA based physically cross-linked polymer hydrogels systems and can be applied in bioengineering and robotic science in the future.
32806276	8	7	theme	normal	1248:1253	arg1	conditions					1255:1264	normal conditions	1248:1264	normal conditions	1248:1264	The hydrogels contain 3-5% of water at normal conditions and confirm its environmental stability.
32806276	2	8	theme	Fe3+	484:487	arg1	content					466:472	the content	462:472	the content of GA and Fe3+ in the composition	462:506	The hydrogels showed a high mechanical strength, self-sustainability and self-healing ability, which depends on the content of GA and Fe3+ in the composition.
32806276	4	9	from	interface	778:786	arg1	existence					742:750	the existence	738:750	the existence of the Fe3+ amount on the interface	738:786	The self-healing performance of the hydrogels enhanced with the existence of the Fe3+ amount on the interface.
32806276	9	10	theme	cross-linked	1394:1405	arg1	systems					1425:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	This work provides a new direction for the synthesis of unmodified GA based physically cross-linked polymer hydrogels systems and can be applied in bioengineering and robotic science in the future.
32806276	4	11	theme	self-healing	682:693	arg1	performance					695:705	The self-healing performance	678:705	The self-healing performance of the hydrogels	678:722	The self-healing performance of the hydrogels enhanced with the existence of the Fe3+ amount on the interface.
32806276	0	12	theme	mechanical	106:115	arg1	performance					153:163	high mechanical, self-sustainable and self-healable performance	101:163	high mechanical, self-sustainable and self-healable performance	101:163	Synthesis of an un-modified gum arabic and acrylic acid based physically cross-linked hydrogels with high mechanical, self-sustainable and self-healable performance.
32806276	1	13	theme	physical	320:327	arg1	Fe3+					310:313	Fe3+	310:313	Fe3+	310:313	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	1	13	theme	physical	320:327	arg1	agent					343:347	a physical cross-linking agent	318:347	a physical cross-linking agent	318:347	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	7	14	theme	excellent	1150:1158	arg1	performance					1179:1189	the excellent fatigue resistance performance	1146:1189	the excellent fatigue resistance performance of the hydrogels	1146:1206	After 4 min of resting time, the percent recovery in dissipated energy reaching a high value of 95%, indicating the excellent fatigue resistance performance of the hydrogels.
32806276	5	15	theme	%	871:871	arg1	ability					852:858	the self-healing ability	835:858	the self-healing ability of up to 70%	835:871	Therefore, the 3% addition of Fe3+, increased the self-healing ability of up to 70%.
32806276	3	16	from	decrease	568:575	arg1	%					606:606	53 to 34%	598:606	53 to 34%	598:606	The fracture stress increased from 0.23 to 0.841 MPa and a decrease in self-healing from 53 to 34% was observed by increasing the GA amount from 12 to 50% respectively.
32806276	3	16	from	decrease	568:575	arg1	self-healing					580:591	self-healing	580:591	self-healing from 53 to 34%	580:606	The fracture stress increased from 0.23 to 0.841 MPa and a decrease in self-healing from 53 to 34% was observed by increasing the GA amount from 12 to 50% respectively.
32806276	0	17	theme	high	101:104	arg1	performance					153:163	high mechanical, self-sustainable and self-healable performance	101:163	high mechanical, self-sustainable and self-healable performance	101:163	Synthesis of an un-modified gum arabic and acrylic acid based physically cross-linked hydrogels with high mechanical, self-sustainable and self-healable performance.
32806276	1	18	theme	cross-linking	329:341	arg1	Fe3+					310:313	Fe3+	310:313	Fe3+	310:313	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	1	18	theme	cross-linking	329:341	arg1	agent					343:347	a physical cross-linking agent	318:347	a physical cross-linking agent	318:347	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	4	19	theme	amount	764:769	arg1	existence					742:750	the existence	738:750	the existence of the Fe3+ amount on the interface	738:786	The self-healing performance of the hydrogels enhanced with the existence of the Fe3+ amount on the interface.
32806276	9	20	theme	hydrogels	1415:1423	arg1	systems					1425:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	This work provides a new direction for the synthesis of unmodified GA based physically cross-linked polymer hydrogels systems and can be applied in bioengineering and robotic science in the future.
32806276	1	21	theme	simple	178:183	arg1	strategy					185:192	A novel and simple strategy	166:192	A novel and simple strategy	166:192	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	2	22	theme	self-healing	423:434	arg1	ability					436:442	self-healing ability	423:442	self-healing ability	423:442	The hydrogels showed a high mechanical strength, self-sustainability and self-healing ability, which depends on the content of GA and Fe3+ in the composition.
32806276	4	23	from	amount	764:769	arg1	interface					778:786	the interface	774:786	the interface	774:786	The self-healing performance of the hydrogels enhanced with the existence of the Fe3+ amount on the interface.
32806276	9	24	theme	GA	1374:1375	arg1	systems					1425:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	This work provides a new direction for the synthesis of unmodified GA based physically cross-linked polymer hydrogels systems and can be applied in bioengineering and robotic science in the future.
32806276	7	25	theme	high	1116:1119	arg1	value					1121:1125	a high value	1114:1125	a high value of 95%	1114:1132	After 4 min of resting time, the percent recovery in dissipated energy reaching a high value of 95%, indicating the excellent fatigue resistance performance of the hydrogels.
32806276	5	26	theme	self-healing	839:850	arg1	ability					852:858	the self-healing ability	835:858	the self-healing ability of up to 70%	835:871	Therefore, the 3% addition of Fe3+, increased the self-healing ability of up to 70%.
32806276	7	27	theme	fatigue	1160:1166	arg1	performance					1179:1189	the excellent fatigue resistance performance	1146:1189	the excellent fatigue resistance performance of the hydrogels	1146:1206	After 4 min of resting time, the percent recovery in dissipated energy reaching a high value of 95%, indicating the excellent fatigue resistance performance of the hydrogels.
32806276	6	28	theme	excellent	916:924	arg1	resistance					934:943	an excellent fatigue resistance	913:943	an excellent fatigue resistance up to 20 cycles	913:959	Furthermore, the hydrogels also showed an excellent fatigue resistance up to 20 cycles without any rapture and can beard a load of 2.5 kg for a very long time.
32806276	9	29	theme	systems	1425:1431	arg1	synthesis					1350:1358	the synthesis	1346:1358	the synthesis of unmodified GA based physically cross-linked polymer hydrogels systems	1346:1431	This work provides a new direction for the synthesis of unmodified GA based physically cross-linked polymer hydrogels systems and can be applied in bioengineering and robotic science in the future.
32806276	6	30	theme	long	1023:1026	arg1	time					1028:1031	a very long time	1016:1031	a very long time	1016:1031	Furthermore, the hydrogels also showed an excellent fatigue resistance up to 20 cycles without any rapture and can beard a load of 2.5 kg for a very long time.
32806276	9	31	from	bioengineering	1455:1468	arg1	future					1497:1502	future	1497:1502	future	1497:1502	This work provides a new direction for the synthesis of unmodified GA based physically cross-linked polymer hydrogels systems and can be applied in bioengineering and robotic science in the future.
32806276	7	32	theme	resistance	1168:1177	arg1	performance					1179:1189	the excellent fatigue resistance performance	1146:1189	the excellent fatigue resistance performance of the hydrogels	1146:1206	After 4 min of resting time, the percent recovery in dissipated energy reaching a high value of 95%, indicating the excellent fatigue resistance performance of the hydrogels.
32806276	0	33	theme	un-modified	16:26	arg1	acid					51:54	an un-modified gum arabic and acrylic acid	13:54	an un-modified gum arabic and acrylic acid	13:54	Synthesis of an un-modified gum arabic and acrylic acid based physically cross-linked hydrogels with high mechanical, self-sustainable and self-healable performance.
32806276	1	34	theme	acrylic	262:268	arg1	acid					270:273	acrylic acid	262:273	acrylic acid (AA)	262:278	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	1	34	theme	acrylic	262:268	arg1	AA					276:277	AA	276:277	AA	276:277	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	0	35	theme	self-sustainable	118:133	arg1	performance					153:163	high mechanical, self-sustainable and self-healable performance	101:163	high mechanical, self-sustainable and self-healable performance	101:163	Synthesis of an un-modified gum arabic and acrylic acid based physically cross-linked hydrogels with high mechanical, self-sustainable and self-healable performance.
32806276	7	36	theme	hydrogels	1198:1206	arg1	performance					1179:1189	the excellent fatigue resistance performance	1146:1189	the excellent fatigue resistance performance of the hydrogels	1146:1206	After 4 min of resting time, the percent recovery in dissipated energy reaching a high value of 95%, indicating the excellent fatigue resistance performance of the hydrogels.
32806276	3	37	theme	fracture	513:520	arg1	stress					522:527	The fracture stress	509:527	The fracture stress	509:527	The fracture stress increased from 0.23 to 0.841 MPa and a decrease in self-healing from 53 to 34% was observed by increasing the GA amount from 12 to 50% respectively.
32806276	1	38	theme	acid	270:273	arg1	synthesis					215:223	the synthesis	211:223	the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA)	211:278	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	9	39	theme	polymer	1407:1413	arg1	systems					1425:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	This work provides a new direction for the synthesis of unmodified GA based physically cross-linked polymer hydrogels systems and can be applied in bioengineering and robotic science in the future.
32806276	9	40	theme	based	1377:1381	arg1	systems					1425:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	This work provides a new direction for the synthesis of unmodified GA based physically cross-linked polymer hydrogels systems and can be applied in bioengineering and robotic science in the future.
32806276	2	41	theme	mechanical	378:387	arg1	strength					389:396	a high mechanical strength	371:396	a high mechanical strength	371:396	The hydrogels showed a high mechanical strength, self-sustainability and self-healing ability, which depends on the content of GA and Fe3+ in the composition.
32806276	0	42	theme	arabic	32:37	arg1	acid					51:54	an un-modified gum arabic and acrylic acid	13:54	an un-modified gum arabic and acrylic acid	13:54	Synthesis of an un-modified gum arabic and acrylic acid based physically cross-linked hydrogels with high mechanical, self-sustainable and self-healable performance.
32806276	7	43	theme	%	1132:1132	arg1	value					1121:1125	a high value	1114:1125	a high value of 95%	1114:1132	After 4 min of resting time, the percent recovery in dissipated energy reaching a high value of 95%, indicating the excellent fatigue resistance performance of the hydrogels.
32806276	0	44	theme	self-healable	139:151	arg1	performance					153:163	high mechanical, self-sustainable and self-healable performance	101:163	high mechanical, self-sustainable and self-healable performance	101:163	Synthesis of an un-modified gum arabic and acrylic acid based physically cross-linked hydrogels with high mechanical, self-sustainable and self-healable performance.
32806276	8	45	theme	environmental	1282:1294	arg1	stability					1296:1304	its environmental stability	1278:1304	its environmental stability	1278:1304	The hydrogels contain 3-5% of water at normal conditions and confirm its environmental stability.
32806276	8	46	theme	water	1239:1243	arg1	water					1239:1243	water	1239:1243	water	1239:1243	The hydrogels contain 3-5% of water at normal conditions and confirm its environmental stability.
32806276	8	46	theme	water	1239:1243	arg1	%					1234:1234	3-5%	1231:1234	3-5% of water	1231:1243	The hydrogels contain 3-5% of water at normal conditions and confirm its environmental stability.
32806276	2	47	theme	high	373:376	arg1	strength					389:396	a high mechanical strength	371:396	a high mechanical strength	371:396	The hydrogels showed a high mechanical strength, self-sustainability and self-healing ability, which depends on the content of GA and Fe3+ in the composition.
32806276	0	48	theme	gum	28:30	arg1	acid					51:54	an un-modified gum arabic and acrylic acid	13:54	an un-modified gum arabic and acrylic acid	13:54	Synthesis of an un-modified gum arabic and acrylic acid based physically cross-linked hydrogels with high mechanical, self-sustainable and self-healable performance.
32806276	3	49	dep	50	660:661	arg1	to					657:658	to	657:658	to	657:658	The fracture stress increased from 0.23 to 0.841 MPa and a decrease in self-healing from 53 to 34% was observed by increasing the GA amount from 12 to 50% respectively.
32806276	9	50	link	cross-linked	1394:1405	arg1	systems					1425:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	unmodified GA based physically cross-linked polymer hydrogels systems	1363:1431	This work provides a new direction for the synthesis of unmodified GA based physically cross-linked polymer hydrogels systems and can be applied in bioengineering and robotic science in the future.
32806276	0	51	link	cross-linked	73:84	arg1	hydrogels					86:94	physically cross-linked hydrogels	62:94	physically cross-linked hydrogels	62:94	Synthesis of an un-modified gum arabic and acrylic acid based physically cross-linked hydrogels with high mechanical, self-sustainable and self-healable performance.
32806276	2	52	theme	GA	477:478	arg1	content					466:472	the content	462:472	the content of GA and Fe3+ in the composition	462:506	The hydrogels showed a high mechanical strength, self-sustainability and self-healing ability, which depends on the content of GA and Fe3+ in the composition.
32806276	0	53	theme	acrylic	43:49	arg1	acid					51:54	an un-modified gum arabic and acrylic acid	13:54	an un-modified gum arabic and acrylic acid	13:54	Synthesis of an un-modified gum arabic and acrylic acid based physically cross-linked hydrogels with high mechanical, self-sustainable and self-healable performance.
32806276	6	54	theme	fatigue	926:932	arg1	resistance					934:943	an excellent fatigue resistance	913:943	an excellent fatigue resistance up to 20 cycles	913:959	Furthermore, the hydrogels also showed an excellent fatigue resistance up to 20 cycles without any rapture and can beard a load of 2.5 kg for a very long time.
32806276	2	55	from	content	466:472	arg1	composition					496:506	the composition	492:506	the composition	492:506	The hydrogels showed a high mechanical strength, self-sustainability and self-healing ability, which depends on the content of GA and Fe3+ in the composition.
32806276	4	56	theme	Fe3+	759:762	arg1	amount					764:769	the Fe3+ amount	755:769	the Fe3+ amount on the interface	755:786	The self-healing performance of the hydrogels enhanced with the existence of the Fe3+ amount on the interface.
32806276	5	57	theme	Fe3+	819:822	arg1	addition					807:814	the 3% addition	800:814	the 3% addition	800:814	Therefore, the 3% addition of Fe3+, increased the self-healing ability of up to 70%.
32806276	7	58	theme	time	1057:1060	arg1	4 min					1040:1044	4 min	1040:1044	4 min of resting time	1040:1060	After 4 min of resting time, the percent recovery in dissipated energy reaching a high value of 95%, indicating the excellent fatigue resistance performance of the hydrogels.
32806276	6	59	theme	2.5 kg	1005:1010	arg1	load					997:1000	a load	995:1000	a load of 2.5 kg for a very long time	995:1031	Furthermore, the hydrogels also showed an excellent fatigue resistance up to 20 cycles without any rapture and can beard a load of 2.5 kg for a very long time.
32806276	1	60	theme	polymer	286:292	arg1	hydrogels					294:302	polymer hydrogels	286:302	polymer hydrogels	286:302	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	2	61	from	GA	477:478	arg1	composition					496:506	the composition	492:506	the composition	492:506	The hydrogels showed a high mechanical strength, self-sustainability and self-healing ability, which depends on the content of GA and Fe3+ in the composition.
32806276	4	62	from	existence	742:750	arg1	interface					778:786	the interface	774:786	the interface	774:786	The self-healing performance of the hydrogels enhanced with the existence of the Fe3+ amount on the interface.
32806276	2	63	from	composition	496:506	arg1	content					466:472	the content	462:472	the content of GA and Fe3+ in the composition	462:506	The hydrogels showed a high mechanical strength, self-sustainability and self-healing ability, which depends on the content of GA and Fe3+ in the composition.
32806276	4	64	theme	hydrogels	714:722	arg1	performance					695:705	The self-healing performance	678:705	The self-healing performance of the hydrogels	678:722	The self-healing performance of the hydrogels enhanced with the existence of the Fe3+ amount on the interface.
32806276	5	65	dep	70	869:870	arg1	to					866:867	to	866:867	to	866:867	Therefore, the 3% addition of Fe3+, increased the self-healing ability of up to 70%.
32806276	3	66	from	%	606:606	arg1	decrease					568:575	a decrease	566:575	a decrease in self-healing from 53 to 34%	566:606	The fracture stress increased from 0.23 to 0.841 MPa and a decrease in self-healing from 53 to 34% was observed by increasing the GA amount from 12 to 50% respectively.
32806276	3	66	from	%	606:606	arg1	self-healing					580:591	self-healing	580:591	self-healing from 53 to 34%	580:606	The fracture stress increased from 0.23 to 0.841 MPa and a decrease in self-healing from 53 to 34% was observed by increasing the GA amount from 12 to 50% respectively.
32806276	2	67	from	Fe3+	484:487	arg1	composition					496:506	the composition	492:506	the composition	492:506	The hydrogels showed a high mechanical strength, self-sustainability and self-healing ability, which depends on the content of GA and Fe3+ in the composition.
32806276	1	68	dep	designed	198:205	arg1	based					280:284	based	280:284	based polymer hydrogels using Fe3+ as a physical cross-linking agent	280:347	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	5	69	theme	3	804:804	arg1	%					805:805	%	805:805	%	805:805	Therefore, the 3% addition of Fe3+, increased the self-healing ability of up to 70%.
32806276	9	70	theme	new	1328:1330	arg1	direction					1332:1340	a new direction	1326:1340	a new direction for the synthesis of unmodified GA based physically cross-linked polymer hydrogels systems	1326:1431	This work provides a new direction for the synthesis of unmodified GA based physically cross-linked polymer hydrogels systems and can be applied in bioengineering and robotic science in the future.
32806276	1	71	theme	unmodified	231:240	arg1	GA					254:255	GA	254:255	GA	254:255	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	1	71	theme	unmodified	231:240	arg1	arabic					246:251	an unmodified gum arabic	228:251	an unmodified gum arabic (GA)	228:256	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	0	72	theme	acid	51:54	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of an un-modified gum arabic and acrylic acid	0:54	Synthesis of an un-modified gum arabic and acrylic acid based physically cross-linked hydrogels with high mechanical, self-sustainable and self-healable performance.
32806276	3	73	theme	GA	639:640	arg1	amount					642:647	the GA amount	635:647	the GA amount	635:647	The fracture stress increased from 0.23 to 0.841 MPa and a decrease in self-healing from 53 to 34% was observed by increasing the GA amount from 12 to 50% respectively.
32806276	3	74	dep	34	604:605	arg1	to					601:602	to	601:602	to	601:602	The fracture stress increased from 0.23 to 0.841 MPa and a decrease in self-healing from 53 to 34% was observed by increasing the GA amount from 12 to 50% respectively.
32806276	5	75	theme	%	805:805	arg1	addition					807:814	the 3% addition	800:814	the 3% addition	800:814	Therefore, the 3% addition of Fe3+, increased the self-healing ability of up to 70%.
32806276	1	76	theme	gum	242:244	arg1	GA					254:255	GA	254:255	GA	254:255	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32806276	1	76	theme	gum	242:244	arg1	arabic					246:251	an unmodified gum arabic	228:251	an unmodified gum arabic (GA)	228:256	A novel and simple strategy was designed for the synthesis of an unmodified gum arabic (GA) and acrylic acid (AA) based polymer hydrogels using Fe3+ as a physical cross-linking agent.
32937769	5	0	theme	=	829:829	arg1	n					827:827	n = 92	827:832	n = 92	827:832	Independent compositions of 163 and 463 N-glycans were found from healthy control (n = 41) and osteoarthritis patients (n = 92), respectively.
32937769	5	0	theme	=	829:829	arg1	patients					817:824	osteoarthritis patients	802:824	osteoarthritis patients (n = 92)	802:833	Independent compositions of 163 and 463 N-glycans were found from healthy control (n = 41) and osteoarthritis patients (n = 92), respectively.
32937769	8	1	theme	larger	1160:1165	arg1	ratio					1154:1158	the P/C ratio	1146:1158	the P/C ratio larger than 3.0	1146:1174	Considering the diagnostic efficacy, the AUC bigger than 0.9 and the P/C ratio larger than 3.0 were used to discover 16 N-glycans as diagnostic biomarkers.
32937769	10	2	from	tool	1430:1433	arg1	area					1461:1464	the veterinary medical area	1438:1464	the veterinary medical area	1438:1464	The results suggest a clear possibility for N-glycan biomarkers to be used as a clinical tool in the veterinary medical area enabling to provide objective and non-invasive diagnostic information.
32937769	7	3	theme	intensity	997:1005	arg1	ratio					1007:1011	the intensity ratio	993:1011	the intensity ratio between OA patient and healthy control (P/C ratio)	993:1062	Then, the area under the curve (AUC) and the intensity ratio between OA patient and healthy control (P/C ratio) were calculated.
32937769	7	3	theme	intensity	997:1005	arg1	ratio					1057:1061	P/C ratio	1053:1061	P/C ratio	1053:1061	Then, the area under the curve (AUC) and the intensity ratio between OA patient and healthy control (P/C ratio) were calculated.
32937769	3	4	theme	osteoarthritis	486:499	arg1	diagnosis					473:481	the diagnosis	469:481	the diagnosis of osteoarthritis (OA), which is one of the most common diseases of dogs	469:554	To evaluate the clinical feasibility in the veterinary area, the N-glycan biomarkers were discovered from canine serum for the diagnosis of osteoarthritis (OA), which is one of the most common diseases of dogs.
32937769	2	5	theme	diagnostic	269:278	arg1	indicator					294:302	a diagnostic or prognostic indicator	267:302	a diagnostic or prognostic indicator of various human diseases such as cancer	267:343	It was sensitively altered by the cellular state and, therefore, is now used for a diagnostic or prognostic indicator of various human diseases such as cancer.
32937769	9	6	theme	diagnostic	1263:1272	arg1	biomarkers					1274:1283	the diagnostic biomarkers	1259:1283	the diagnostic biomarkers were AUC above 0.99	1259:1303	Particularly, five of the diagnostic biomarkers were AUC above 0.99 and three of N-glycans had AUC 1.0.
32937769	1	7	theme	Protein	64:70	arg1	glycosylation					72:84	Protein glycosylation	64:84	Protein glycosylation	64:84	Protein glycosylation is a post-translational modification that impacts on protein activity, stability, and interactions.
32937769	1	7	theme	Protein	64:70	arg1	modification					110:121	a post-translational modification	89:121	a post-translational modification that impacts on protein activity, stability, and interactions	89:183	Protein glycosylation is a post-translational modification that impacts on protein activity, stability, and interactions.
32937769	8	8	theme	P/C	1150:1152	arg1	ratio					1154:1158	the P/C ratio	1146:1158	the P/C ratio larger than 3.0	1146:1174	Considering the diagnostic efficacy, the AUC bigger than 0.9 and the P/C ratio larger than 3.0 were used to discover 16 N-glycans as diagnostic biomarkers.
32937769	7	9	theme	P/C	1053:1055	arg1	ratio					1007:1011	the intensity ratio	993:1011	the intensity ratio between OA patient and healthy control (P/C ratio)	993:1062	Then, the area under the curve (AUC) and the intensity ratio between OA patient and healthy control (P/C ratio) were calculated.
32937769	7	9	theme	P/C	1053:1055	arg1	ratio					1057:1061	P/C ratio	1053:1061	P/C ratio	1053:1061	Then, the area under the curve (AUC) and the intensity ratio between OA patient and healthy control (P/C ratio) were calculated.
32937769	10	10	theme	non-invasive	1500:1511	arg1	information					1524:1534	objective and non-invasive diagnostic information	1486:1534	objective and non-invasive diagnostic information	1486:1534	The results suggest a clear possibility for N-glycan biomarkers to be used as a clinical tool in the veterinary medical area enabling to provide objective and non-invasive diagnostic information.
32937769	10	11	theme	veterinary	1442:1451	arg1	area					1461:1464	the veterinary medical area	1438:1464	the veterinary medical area	1438:1464	The results suggest a clear possibility for N-glycan biomarkers to be used as a clinical tool in the veterinary medical area enabling to provide objective and non-invasive diagnostic information.
32937769	8	12	used	used	1181:1184	arg2	ratio					1154:1158	the P/C ratio	1146:1158	the P/C ratio larger than 3.0	1146:1174	Considering the diagnostic efficacy, the AUC bigger than 0.9 and the P/C ratio larger than 3.0 were used to discover 16 N-glycans as diagnostic biomarkers.
32937769	8	12	used	used	1181:1184	arg2	AUC					1122:1124	the AUC	1118:1124	the AUC bigger than 0.9	1118:1140	Considering the diagnostic efficacy, the AUC bigger than 0.9 and the P/C ratio larger than 3.0 were used to discover 16 N-glycans as diagnostic biomarkers.
32937769	3	13	theme	N-glycan	411:418	arg1	biomarkers					420:429	the N-glycan biomarkers	407:429	the N-glycan biomarkers	407:429	To evaluate the clinical feasibility in the veterinary area, the N-glycan biomarkers were discovered from canine serum for the diagnosis of osteoarthritis (OA), which is one of the most common diseases of dogs.
32937769	9	14	theme	biomarkers	1274:1283	arg1	five					1251:1254	five	1251:1254	five	1251:1254	Particularly, five of the diagnostic biomarkers were AUC above 0.99 and three of N-glycans had AUC 1.0.
32937769	9	14	theme	biomarkers	1274:1283	arg1	biomarkers					1274:1283	the diagnostic biomarkers	1259:1283	the diagnostic biomarkers were AUC above 0.99	1259:1303	Particularly, five of the diagnostic biomarkers were AUC above 0.99 and three of N-glycans had AUC 1.0.
32937769	7	15	theme	OA	1021:1022	arg1	patient					1024:1030	OA patient	1021:1030	OA patient	1021:1030	Then, the area under the curve (AUC) and the intensity ratio between OA patient and healthy control (P/C ratio) were calculated.
32937769	4	16	theme	canine	594:599	arg1	serum					601:605	canine serum	594:605	canine serum	594:605	N-glycome was obtained from 20 μL of canine serum by the enzymatic cleavage followed by the purification and enrichment using solid-phase extraction.
32937769	3	17	theme	clinical	362:369	arg1	feasibility					371:381	the clinical feasibility	358:381	the clinical feasibility in the veterinary area	358:404	To evaluate the clinical feasibility in the veterinary area, the N-glycan biomarkers were discovered from canine serum for the diagnosis of osteoarthritis (OA), which is one of the most common diseases of dogs.
32937769	3	18	from	feasibility	371:381	arg1	area					401:404	the veterinary area	386:404	the veterinary area	386:404	To evaluate the clinical feasibility in the veterinary area, the N-glycan biomarkers were discovered from canine serum for the diagnosis of osteoarthritis (OA), which is one of the most common diseases of dogs.
32937769	10	19	theme	N-glycan	1385:1392	arg1	biomarkers					1394:1403	N-glycan biomarkers	1385:1403	N-glycan biomarkers	1385:1403	The results suggest a clear possibility for N-glycan biomarkers to be used as a clinical tool in the veterinary medical area enabling to provide objective and non-invasive diagnostic information.
32937769	4	20	theme	solid-phase	683:693	arg1	extraction					695:704	solid-phase extraction	683:704	solid-phase extraction	683:704	N-glycome was obtained from 20 μL of canine serum by the enzymatic cleavage followed by the purification and enrichment using solid-phase extraction.
32937769	5	21	theme	osteoarthritis	802:815	arg1	n					827:827	n = 92	827:832	n = 92	827:832	Independent compositions of 163 and 463 N-glycans were found from healthy control (n = 41) and osteoarthritis patients (n = 92), respectively.
32937769	5	21	theme	osteoarthritis	802:815	arg1	patients					817:824	osteoarthritis patients	802:824	osteoarthritis patients (n = 92)	802:833	Independent compositions of 163 and 463 N-glycans were found from healthy control (n = 41) and osteoarthritis patients (n = 92), respectively.
32937769	10	22	theme	clinical	1421:1428	arg1	tool					1430:1433	a clinical tool	1419:1433	a clinical tool in the veterinary medical area	1419:1464	The results suggest a clear possibility for N-glycan biomarkers to be used as a clinical tool in the veterinary medical area enabling to provide objective and non-invasive diagnostic information.
32937769	1	23	theme	post-translational	91:108	arg1	glycosylation					72:84	Protein glycosylation	64:84	Protein glycosylation	64:84	Protein glycosylation is a post-translational modification that impacts on protein activity, stability, and interactions.
32937769	1	23	theme	post-translational	91:108	arg1	modification					110:121	a post-translational modification	89:121	a post-translational modification that impacts on protein activity, stability, and interactions	89:183	Protein glycosylation is a post-translational modification that impacts on protein activity, stability, and interactions.
32937769	0	24	theme	Biomarkers	22:31	arg1	Discovery					0:8	Discovery	0:8	Discovery of N-glycan Biomarkers for the Canine Osteoarthritis.	0:62	Discovery of N-glycan Biomarkers for the Canine Osteoarthritis.
32937769	6	25	theme	biomarkers	881:890	arg1	31					861:862	31	861:862	31	861:862	Initially, 31 of the potential biomarkers were screened by the p-values below 1.0 × 10-10 from ANOVA.
32937769	6	25	theme	biomarkers	881:890	arg1	biomarkers					881:890	the potential biomarkers	867:890	the potential biomarkers	867:890	Initially, 31 of the potential biomarkers were screened by the p-values below 1.0 × 10-10 from ANOVA.
32937769	3	26	theme	diseases	539:546	arg1	diseases					539:546	the most common diseases	523:546	the most common diseases of dogs	523:554	To evaluate the clinical feasibility in the veterinary area, the N-glycan biomarkers were discovered from canine serum for the diagnosis of osteoarthritis (OA), which is one of the most common diseases of dogs.
32937769	3	26	theme	diseases	539:546	arg1	one					516:518	one	516:518	one	516:518	To evaluate the clinical feasibility in the veterinary area, the N-glycan biomarkers were discovered from canine serum for the diagnosis of osteoarthritis (OA), which is one of the most common diseases of dogs.
32937769	2	27	theme	prognostic	283:292	arg1	indicator					294:302	a diagnostic or prognostic indicator	267:302	a diagnostic or prognostic indicator of various human diseases such as cancer	267:343	It was sensitively altered by the cellular state and, therefore, is now used for a diagnostic or prognostic indicator of various human diseases such as cancer.
32937769	8	28	theme	bigger	1126:1131	arg1	AUC					1122:1124	the AUC	1118:1124	the AUC bigger than 0.9	1118:1140	Considering the diagnostic efficacy, the AUC bigger than 0.9 and the P/C ratio larger than 3.0 were used to discover 16 N-glycans as diagnostic biomarkers.
32937769	0	29	theme	N-glycan	13:20	arg1	Biomarkers					22:31	N-glycan Biomarkers	13:31	N-glycan Biomarkers	13:31	Discovery of N-glycan Biomarkers for the Canine Osteoarthritis.
32937769	6	30	theme	potential	871:879	arg1	biomarkers					881:890	the potential biomarkers	867:890	the potential biomarkers	867:890	Initially, 31 of the potential biomarkers were screened by the p-values below 1.0 × 10-10 from ANOVA.
32937769	8	31	theme	diagnostic	1214:1223	arg1	biomarkers					1225:1234	diagnostic biomarkers	1214:1234	diagnostic biomarkers	1214:1234	Considering the diagnostic efficacy, the AUC bigger than 0.9 and the P/C ratio larger than 3.0 were used to discover 16 N-glycans as diagnostic biomarkers.
32937769	3	32	theme	canine	452:457	arg1	serum					459:463	canine serum	452:463	canine serum for the diagnosis of osteoarthritis (OA), which is one of the most common diseases of dogs	452:554	To evaluate the clinical feasibility in the veterinary area, the N-glycan biomarkers were discovered from canine serum for the diagnosis of osteoarthritis (OA), which is one of the most common diseases of dogs.
32937769	3	33	theme	veterinary	390:399	arg1	area					401:404	the veterinary area	386:404	the veterinary area	386:404	To evaluate the clinical feasibility in the veterinary area, the N-glycan biomarkers were discovered from canine serum for the diagnosis of osteoarthritis (OA), which is one of the most common diseases of dogs.
32937769	5	34	theme	=	792:792	arg1	n					790:790	n = 41	790:795	n = 41	790:795	Independent compositions of 163 and 463 N-glycans were found from healthy control (n = 41) and osteoarthritis patients (n = 92), respectively.
32937769	5	34	theme	=	792:792	arg1	control					781:787	healthy control	773:787	healthy control (n = 41)	773:796	Independent compositions of 163 and 463 N-glycans were found from healthy control (n = 41) and osteoarthritis patients (n = 92), respectively.
32937769	4	35	theme	serum	601:605	arg1	μL					588:589	20 μL	585:589	20 μL of canine serum	585:605	N-glycome was obtained from 20 μL of canine serum by the enzymatic cleavage followed by the purification and enrichment using solid-phase extraction.
32937769	9	36	contain	had	1328:1330	arg1	three					1309:1313	three	1309:1313	three	1309:1313	Particularly, five of the diagnostic biomarkers were AUC above 0.99 and three of N-glycans had AUC 1.0.
32937769	9	36	contain	had	1328:1330	arg1	five					1251:1254	five	1251:1254	five	1251:1254	Particularly, five of the diagnostic biomarkers were AUC above 0.99 and three of N-glycans had AUC 1.0.
32937769	9	36	contain	had	1328:1330	arg1	N-glycans					1318:1326	N-glycans	1318:1326	N-glycans	1318:1326	Particularly, five of the diagnostic biomarkers were AUC above 0.99 and three of N-glycans had AUC 1.0.
32937769	9	36	contain	had	1328:1330	arg2	AUC					1332:1334	AUC 1.0	1332:1338	AUC 1.0	1332:1338	Particularly, five of the diagnostic biomarkers were AUC above 0.99 and three of N-glycans had AUC 1.0.
32937769	9	36	contain	had	1328:1330	arg1	biomarkers					1274:1283	the diagnostic biomarkers	1259:1283	the diagnostic biomarkers were AUC above 0.99	1259:1303	Particularly, five of the diagnostic biomarkers were AUC above 0.99 and three of N-glycans had AUC 1.0.
32937769	3	37	theme	dogs	551:554	arg1	diseases					539:546	the most common diseases	523:546	the most common diseases of dogs	523:554	To evaluate the clinical feasibility in the veterinary area, the N-glycan biomarkers were discovered from canine serum for the diagnosis of osteoarthritis (OA), which is one of the most common diseases of dogs.
32937769	5	38	theme	healthy	773:779	arg1	n					790:790	n = 41	790:795	n = 41	790:795	Independent compositions of 163 and 463 N-glycans were found from healthy control (n = 41) and osteoarthritis patients (n = 92), respectively.
32937769	5	38	theme	healthy	773:779	arg1	control					781:787	healthy control	773:787	healthy control (n = 41)	773:796	Independent compositions of 163 and 463 N-glycans were found from healthy control (n = 41) and osteoarthritis patients (n = 92), respectively.
32937769	5	39	theme	N-glycans	747:755	arg1	compositions					719:730	Independent compositions	707:730	Independent compositions of 163 and 463 N-glycans	707:755	Independent compositions of 163 and 463 N-glycans were found from healthy control (n = 41) and osteoarthritis patients (n = 92), respectively.
32937769	3	40	theme	common	532:537	arg1	diseases					539:546	the most common diseases	523:546	the most common diseases of dogs	523:554	To evaluate the clinical feasibility in the veterinary area, the N-glycan biomarkers were discovered from canine serum for the diagnosis of osteoarthritis (OA), which is one of the most common diseases of dogs.
32937769	0	41	theme	Canine	41:46	arg1	Osteoarthritis					48:61	the Canine Osteoarthritis	37:61	the Canine Osteoarthritis	37:61	Discovery of N-glycan Biomarkers for the Canine Osteoarthritis.
32937769	2	42	theme	cellular	220:227	arg1	state					229:233	the cellular state	216:233	the cellular state	216:233	It was sensitively altered by the cellular state and, therefore, is now used for a diagnostic or prognostic indicator of various human diseases such as cancer.
32937769	2	43	theme	diseases	321:328	arg1	indicator					294:302	a diagnostic or prognostic indicator	267:302	a diagnostic or prognostic indicator of various human diseases such as cancer	267:343	It was sensitively altered by the cellular state and, therefore, is now used for a diagnostic or prognostic indicator of various human diseases such as cancer.
32937769	10	44	theme	medical	1453:1459	arg1	area					1461:1464	the veterinary medical area	1438:1464	the veterinary medical area	1438:1464	The results suggest a clear possibility for N-glycan biomarkers to be used as a clinical tool in the veterinary medical area enabling to provide objective and non-invasive diagnostic information.
32937769	1	45	theme	protein	139:145	arg1	activity					147:154	protein activity	139:154	protein activity	139:154	Protein glycosylation is a post-translational modification that impacts on protein activity, stability, and interactions.
32937769	4	46	dep	purification	649:660	arg1	the					645:647	the	645:647	the	645:647	N-glycome was obtained from 20 μL of canine serum by the enzymatic cleavage followed by the purification and enrichment using solid-phase extraction.
32937769	2	47	dep	altered	205:211	arg1	used					258:261	used	258:261	is now used for a diagnostic or prognostic indicator of various human diseases such as cancer	251:343	It was sensitively altered by the cellular state and, therefore, is now used for a diagnostic or prognostic indicator of various human diseases such as cancer.
32937769	10	48	theme	objective	1486:1494	arg1	information					1524:1534	objective and non-invasive diagnostic information	1486:1534	objective and non-invasive diagnostic information	1486:1534	The results suggest a clear possibility for N-glycan biomarkers to be used as a clinical tool in the veterinary medical area enabling to provide objective and non-invasive diagnostic information.
32937769	2	49	theme	various	307:313	arg1	diseases					321:328	various human diseases	307:328	various human diseases such as cancer	307:343	It was sensitively altered by the cellular state and, therefore, is now used for a diagnostic or prognostic indicator of various human diseases such as cancer.
32937769	2	49	theme	various	307:313	arg1	cancer					338:343	cancer	338:343	cancer	338:343	It was sensitively altered by the cellular state and, therefore, is now used for a diagnostic or prognostic indicator of various human diseases such as cancer.
32937769	2	50	theme	human	315:319	arg1	diseases					321:328	various human diseases	307:328	various human diseases such as cancer	307:343	It was sensitively altered by the cellular state and, therefore, is now used for a diagnostic or prognostic indicator of various human diseases such as cancer.
32937769	2	50	theme	human	315:319	arg1	cancer					338:343	cancer	338:343	cancer	338:343	It was sensitively altered by the cellular state and, therefore, is now used for a diagnostic or prognostic indicator of various human diseases such as cancer.
32937769	5	51	theme	Independent	707:717	arg1	compositions					719:730	Independent compositions	707:730	Independent compositions of 163 and 463 N-glycans	707:755	Independent compositions of 163 and 463 N-glycans were found from healthy control (n = 41) and osteoarthritis patients (n = 92), respectively.
32937769	9	52	theme	N-glycans	1318:1326	arg1	three					1309:1313	three	1309:1313	three	1309:1313	Particularly, five of the diagnostic biomarkers were AUC above 0.99 and three of N-glycans had AUC 1.0.
32937769	9	52	theme	N-glycans	1318:1326	arg1	N-glycans					1318:1326	N-glycans	1318:1326	N-glycans	1318:1326	Particularly, five of the diagnostic biomarkers were AUC above 0.99 and three of N-glycans had AUC 1.0.
32937769	10	53	theme	diagnostic	1513:1522	arg1	information					1524:1534	objective and non-invasive diagnostic information	1486:1534	objective and non-invasive diagnostic information	1486:1534	The results suggest a clear possibility for N-glycan biomarkers to be used as a clinical tool in the veterinary medical area enabling to provide objective and non-invasive diagnostic information.
32937769	8	54	theme	diagnostic	1097:1106	arg1	efficacy					1108:1115	the diagnostic efficacy	1093:1115	the diagnostic efficacy	1093:1115	Considering the diagnostic efficacy, the AUC bigger than 0.9 and the P/C ratio larger than 3.0 were used to discover 16 N-glycans as diagnostic biomarkers.
32937769	10	55	theme	clear	1363:1367	arg1	possibility					1369:1379	a clear possibility	1361:1379	a clear possibility for N-glycan biomarkers to be used as a clinical tool in the veterinary medical area enabling to provide objective and non-invasive diagnostic information	1361:1534	The results suggest a clear possibility for N-glycan biomarkers to be used as a clinical tool in the veterinary medical area enabling to provide objective and non-invasive diagnostic information.
32937769	7	56	theme	healthy	1036:1042	arg1	control					1044:1050	healthy control	1036:1050	healthy control	1036:1050	Then, the area under the curve (AUC) and the intensity ratio between OA patient and healthy control (P/C ratio) were calculated.
32937769	4	57	theme	enzymatic	614:622	arg1	cleavage					624:631	the enzymatic cleavage	610:631	the enzymatic cleavage followed by the purification and enrichment using solid-phase extraction	610:704	N-glycome was obtained from 20 μL of canine serum by the enzymatic cleavage followed by the purification and enrichment using solid-phase extraction.
32937769	2	58	used	used	258:261	arg2	It					186:187	It	186:187	It	186:187	It was sensitively altered by the cellular state and, therefore, is now used for a diagnostic or prognostic indicator of various human diseases such as cancer.
33668823	4	0	theme	M-SHIME®	846:853	arg1	study					855:859	the M-SHIME® study	842:859	the M-SHIME® study	842:859	The short-term model allowed the screening of five donors for each group and provided supportive data for the M-SHIME® study.
33668823	3	1	theme	[M-SHIME®	631:639	arg1	simulator					577:585	the long-term mucosal simulator	555:585	the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®	555:639	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	3	1	theme	[M-SHIME®	631:639	arg1	incubations					539:549	48 h fecal incubations	528:549	48 h fecal incubations	528:549	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	7	2	theme	2'-FL	1342:1346	arg1	fermentation					1348:1359	2'-FL fermentation	1342:1359	2'-FL fermentation	1342:1359	Notably, consistently lower gas production was observed with 2'-FL fermentation as compared to lactose, suggesting that reduced discomfort during the dynamic microbiome establishment in early life may be an advantage along with the bifidogenic effect observed.
33668823	3	3	theme	microbial	611:619	arg1	[M-SHIME®					631:639	the human intestinal microbial ecosystem [M-SHIME®	590:639	the human intestinal microbial ecosystem [M-SHIME®	590:639	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	7	4	theme	early	1467:1471	arg1	life					1473:1476	early life	1467:1476	early life	1467:1476	Notably, consistently lower gas production was observed with 2'-FL fermentation as compared to lactose, suggesting that reduced discomfort during the dynamic microbiome establishment in early life may be an advantage along with the bifidogenic effect observed.
33668823	0	5	theme	Fucosyllactose	42:55	arg1	Effects					29:35	the In Vitro Effects	16:35	the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers	16:143	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	1	6	theme	life	280:283	arg1	months					270:275	the first 6 months	258:275	the first 6 months of life	258:283	Because of the recognized health benefits of breast milk, it is recommended as the sole nutrition source during the first 6 months of life.
33668823	5	7	from	microbiota	1025:1034	arg1	M-SHIME®					1043:1050	the M-SHIME®	1039:1050	the M-SHIME®	1039:1050	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	0	8	from	Infants	124:130	arg1	Activity					92:99	Activity	92:99	Activity	92:99	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	0	8	from	Infants	124:130	arg1	Composition					76:86	Composition	76:86	Composition	76:86	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	5	9	theme	Bifidobacteriaceae	943:960	arg1	abundance					930:938	the relative abundance	917:938	the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®	917:1050	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	5	10	theme	BF	1003:1004	arg1	infant					1006:1011	the BF infant	999:1011	the BF infant	999:1011	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	5	11	from	infant	1006:1011	arg1	M-SHIME®					1043:1050	the M-SHIME®	1039:1050	the M-SHIME®	1039:1050	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	0	12	dep	Composition	76:86	arg1	the					72:74	the	72:74	the	72:74	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	5	13	theme	toddler	1017:1023	arg1	microbiota					1025:1034	toddler microbiota	1017:1034	toddler microbiota in the M-SHIME®	1017:1050	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	0	14	theme	Lactose	61:67	arg1	Effects					29:35	the In Vitro Effects	16:35	the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers	16:143	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	3	15	theme	mucosal	569:575	arg1	simulator					577:585	the long-term mucosal simulator	555:585	the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®	555:639	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	4	16	theme	short-term	740:749	arg1	model					751:755	The short-term model	736:755	The short-term model	736:755	The short-term model allowed the screening of five donors for each group and provided supportive data for the M-SHIME® study.
33668823	3	17	theme	HMO	471:473	arg1	2'-FL					493:497	2'-FL	493:497	2'-FL	493:497	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	3	17	theme	HMO	471:473	arg1	fucosyllactose					477:490	HMO 2'fucosyllactose	471:490	HMO 2'fucosyllactose (2'-FL)	471:498	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	6	18	theme	health-related	1197:1210	arg1	propionate					1212:1221	the health-related propionate	1193:1221	the health-related propionate	1193:1221	At the metabolic level, while decreasing branched-chain fatty acids, 2'-FL strongly increased acetate production together with increases in the health-related propionate and butyrate whilst gas production only mildly increased.
33668823	4	19	theme	supportive	822:831	arg1	data					833:836	supportive data	822:836	supportive data for the M-SHIME® study	822:859	The short-term model allowed the screening of five donors for each group and provided supportive data for the M-SHIME® study.
33668823	0	20	from	Effects	29:35	arg1	Activity					92:99	Activity	92:99	Activity	92:99	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	0	20	from	Effects	29:35	arg1	Composition					76:86	Composition	76:86	Composition	76:86	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	3	21	dep	in	511:512	arg1	vitro					514:518	vitro	514:518	vitro	514:518	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	3	22	theme	microbiota	444:453	arg1	fermentation					455:466	the gut microbiota fermentation	436:466	the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL)	436:498	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	2	23	theme	activity	381:388	arg1	part					367:370	part	367:370	part of their activity	367:388	Among the bioactive components are human milk oligosaccharides (HMOs) that exert part of their activity via the gut microbiota.
33668823	3	24	theme	human	594:598	arg1	[M-SHIME®					631:639	the human intestinal microbial ecosystem [M-SHIME®	590:639	the human intestinal microbial ecosystem [M-SHIME®	590:639	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	7	25	theme	dynamic	1431:1437	arg1	establishment					1450:1462	the dynamic microbiome establishment	1427:1462	the dynamic microbiome establishment	1427:1462	Notably, consistently lower gas production was observed with 2'-FL fermentation as compared to lactose, suggesting that reduced discomfort during the dynamic microbiome establishment in early life may be an advantage along with the bifidogenic effect observed.
33668823	6	26	dep	together	1166:1173	arg1	with					1175:1178	with	1175:1178	with	1175:1178	At the metabolic level, while decreasing branched-chain fatty acids, 2'-FL strongly increased acetate production together with increases in the health-related propionate and butyrate whilst gas production only mildly increased.
33668823	2	27	theme	milk	327:330	arg1	HMOs					350:353	HMOs	350:353	HMOs	350:353	Among the bioactive components are human milk oligosaccharides (HMOs) that exert part of their activity via the gut microbiota.
33668823	2	27	theme	milk	327:330	arg1	oligosaccharides					332:347	human milk oligosaccharides	321:347	human milk oligosaccharides (HMOs) that exert part of their activity via the gut microbiota	321:411	Among the bioactive components are human milk oligosaccharides (HMOs) that exert part of their activity via the gut microbiota.
33668823	3	28	theme	intestinal	600:609	arg1	[M-SHIME®					631:639	the human intestinal microbial ecosystem [M-SHIME®	590:639	the human intestinal microbial ecosystem [M-SHIME®	590:639	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	3	29	with	models	520:525	arg1	samples					654:660	fecal samples	648:660	fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers	648:733	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	3	30	theme	fucosyllactose	477:490	arg1	fermentation					455:466	the gut microbiota fermentation	436:466	the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL)	436:498	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	3	31	theme	ecosystem	621:629	arg1	[M-SHIME®					631:639	the human intestinal microbial ecosystem [M-SHIME®	590:639	the human intestinal microbial ecosystem [M-SHIME®	590:639	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	2	32	theme	human	321:325	arg1	HMOs					350:353	HMOs	350:353	HMOs	350:353	Among the bioactive components are human milk oligosaccharides (HMOs) that exert part of their activity via the gut microbiota.
33668823	2	32	theme	human	321:325	arg1	oligosaccharides					332:347	human milk oligosaccharides	321:347	human milk oligosaccharides (HMOs) that exert part of their activity via the gut microbiota	321:411	Among the bioactive components are human milk oligosaccharides (HMOs) that exert part of their activity via the gut microbiota.
33668823	0	33	from	Comparison	2:11	arg1	Activity					92:99	Activity	92:99	Activity	92:99	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	0	33	from	Comparison	2:11	arg1	Composition					76:86	Composition	76:86	Composition	76:86	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	6	34	theme	fatty	1109:1113	arg1	acids					1115:1119	branched-chain fatty acids	1094:1119	branched-chain fatty acids	1094:1119	At the metabolic level, while decreasing branched-chain fatty acids, 2'-FL strongly increased acetate production together with increases in the health-related propionate and butyrate whilst gas production only mildly increased.
33668823	7	35	theme	microbiome	1439:1448	arg1	establishment					1450:1462	the dynamic microbiome establishment	1427:1462	the dynamic microbiome establishment	1427:1462	Notably, consistently lower gas production was observed with 2'-FL fermentation as compared to lactose, suggesting that reduced discomfort during the dynamic microbiome establishment in early life may be an advantage along with the bifidogenic effect observed.
33668823	7	36	theme	reduced	1401:1407	arg1	discomfort					1409:1418	reduced discomfort	1401:1418	reduced discomfort during the dynamic microbiome establishment in early life	1401:1476	Notably, consistently lower gas production was observed with 2'-FL fermentation as compared to lactose, suggesting that reduced discomfort during the dynamic microbiome establishment in early life may be an advantage along with the bifidogenic effect observed.
33668823	7	36	theme	reduced	1401:1407	arg1	advantage					1488:1496	an advantage	1485:1496	an advantage	1485:1496	Notably, consistently lower gas production was observed with 2'-FL fermentation as compared to lactose, suggesting that reduced discomfort during the dynamic microbiome establishment in early life may be an advantage along with the bifidogenic effect observed.
33668823	5	37	theme	relative	921:928	arg1	abundance					930:938	the relative abundance	917:938	the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®	917:1050	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	1	38	theme	sole	229:232	arg1	source					244:249	the sole nutrition source	225:249	the sole nutrition source during the first 6 months of life	225:283	Because of the recognized health benefits of breast milk, it is recommended as the sole nutrition source during the first 6 months of life.
33668823	1	38	theme	sole	229:232	arg1	it					204:205	it	204:205	it	204:205	Because of the recognized health benefits of breast milk, it is recommended as the sole nutrition source during the first 6 months of life.
33668823	3	39	from	infants	694:700	arg1	samples					654:660	fecal samples	648:660	fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers	648:733	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	5	40	theme	strong	884:889	arg1	increase					905:912	the strong and immediate increase	880:912	the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®	880:1050	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	5	40	theme	strong	884:889	arg1	finding					868:874	A key finding	862:874	A key finding	862:874	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	7	41	theme	lower	1303:1307	arg1	production					1313:1322	consistently lower gas production	1290:1322	consistently lower gas production	1290:1322	Notably, consistently lower gas production was observed with 2'-FL fermentation as compared to lactose, suggesting that reduced discomfort during the dynamic microbiome establishment in early life may be an advantage along with the bifidogenic effect observed.
33668823	1	42	theme	nutrition	234:242	arg1	source					244:249	the sole nutrition source	225:249	the sole nutrition source during the first 6 months of life	225:283	Because of the recognized health benefits of breast milk, it is recommended as the sole nutrition source during the first 6 months of life.
33668823	1	42	theme	nutrition	234:242	arg1	it					204:205	it	204:205	it	204:205	Because of the recognized health benefits of breast milk, it is recommended as the sole nutrition source during the first 6 months of life.
33668823	7	43	theme	gas	1309:1311	arg1	production					1313:1322	consistently lower gas production	1290:1322	consistently lower gas production	1290:1322	Notably, consistently lower gas production was observed with 2'-FL fermentation as compared to lactose, suggesting that reduced discomfort during the dynamic microbiome establishment in early life may be an advantage along with the bifidogenic effect observed.
33668823	3	44	theme	h	531:531	arg1	incubations					539:549	48 h fecal incubations	528:549	48 h fecal incubations	528:549	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	3	45	from	toddlers	726:733	arg1	samples					654:660	fecal samples	648:660	fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers	648:733	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	1	46	theme	recognized	161:170	arg1	benefits					179:186	the recognized health benefits	157:186	the recognized health benefits of breast milk	157:201	Because of the recognized health benefits of breast milk, it is recommended as the sole nutrition source during the first 6 months of life.
33668823	2	47	theme	gut	398:400	arg1	microbiota					402:411	the gut microbiota	394:411	the gut microbiota	394:411	Among the bioactive components are human milk oligosaccharides (HMOs) that exert part of their activity via the gut microbiota.
33668823	0	48	from	Toddlers	136:143	arg1	Activity					92:99	Activity	92:99	Activity	92:99	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	0	48	from	Toddlers	136:143	arg1	Composition					76:86	Composition	76:86	Composition	76:86	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	0	49	theme	Gut	104:106	arg1	Microbiota					108:117	Gut Microbiota	104:117	Gut Microbiota	104:117	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	3	50	theme	fecal	533:537	arg1	incubations					539:549	48 h fecal incubations	528:549	48 h fecal incubations	528:549	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	6	51	theme	branched-chain	1094:1107	arg1	acids					1115:1119	branched-chain fatty acids	1094:1119	branched-chain fatty acids	1094:1119	At the metabolic level, while decreasing branched-chain fatty acids, 2'-FL strongly increased acetate production together with increases in the health-related propionate and butyrate whilst gas production only mildly increased.
33668823	1	52	theme	health	172:177	arg1	benefits					179:186	the recognized health benefits	157:186	the recognized health benefits of breast milk	157:201	Because of the recognized health benefits of breast milk, it is recommended as the sole nutrition source during the first 6 months of life.
33668823	0	53	theme	In	20:21	arg1	Effects					29:35	the In Vitro Effects	16:35	the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers	16:143	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	3	54	theme	fecal	648:652	arg1	samples					654:660	fecal samples	648:660	fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers	648:733	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	0	55	from	Activity	92:99	arg1	Comparison					2:11	A Comparison	0:11	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.	0:144	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	3	56	dep	models	520:525	arg1	simulator					577:585	the long-term mucosal simulator	555:585	the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®	555:639	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	3	56	dep	models	520:525	arg1	incubations					539:549	48 h fecal incubations	528:549	48 h fecal incubations	528:549	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	3	57	theme	3-month-old	667:677	arg1	infants					694:700	3-month-old breastfed (BF) infants	667:700	3-month-old breastfed (BF) infants as well as 2-3 year old toddlers	667:733	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	3	58	theme	48	528:529	arg1	h					531:531	h	531:531	h	531:531	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	5	59	theme	2'-FL	972:976	arg1	fermentation					978:989	2'-FL fermentation	972:989	2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®	972:1050	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	0	60	theme	Effects	29:35	arg1	Comparison					2:11	A Comparison	0:11	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.	0:144	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	1	61	theme	first	262:266	arg1	months					270:275	the first 6 months	258:275	the first 6 months of life	258:283	Because of the recognized health benefits of breast milk, it is recommended as the sole nutrition source during the first 6 months of life.
33668823	0	62	theme	Microbiota	108:117	arg1	Activity					92:99	Activity	92:99	Activity	92:99	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	0	62	theme	Microbiota	108:117	arg1	Composition					76:86	Composition	76:86	Composition	76:86	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	0	63	from	Composition	76:86	arg1	Comparison					2:11	A Comparison	0:11	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.	0:144	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	0	64	dep	In	20:21	arg1	Vitro					23:27	Vitro	23:27	Vitro	23:27	A Comparison of the In Vitro Effects of 2'Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers.
33668823	7	65	from	discomfort	1409:1418	arg1	life					1473:1476	early life	1467:1476	early life	1467:1476	Notably, consistently lower gas production was observed with 2'-FL fermentation as compared to lactose, suggesting that reduced discomfort during the dynamic microbiome establishment in early life may be an advantage along with the bifidogenic effect observed.
33668823	3	66	theme	old	722:724	arg1	toddlers					726:733	2-3 year old toddlers	713:733	3-month-old breastfed (BF) infants as well as 2-3 year old toddlers	667:733	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	5	67	theme	key	864:866	arg1	increase					905:912	the strong and immediate increase	880:912	the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®	880:1050	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	5	67	theme	key	864:866	arg1	finding					868:874	A key finding	862:874	A key finding	862:874	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	6	68	theme	acetate	1147:1153	arg1	production					1155:1164	acetate production	1147:1164	acetate production together with increases in the health-related propionate and butyrate	1147:1234	At the metabolic level, while decreasing branched-chain fatty acids, 2'-FL strongly increased acetate production together with increases in the health-related propionate and butyrate whilst gas production only mildly increased.
33668823	3	69	theme	long-term	559:567	arg1	simulator					577:585	the long-term mucosal simulator	555:585	the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®	555:639	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	6	70	from	increases	1180:1188	arg1	butyrate					1227:1234	butyrate	1227:1234	butyrate	1227:1234	At the metabolic level, while decreasing branched-chain fatty acids, 2'-FL strongly increased acetate production together with increases in the health-related propionate and butyrate whilst gas production only mildly increased.
33668823	6	70	from	increases	1180:1188	arg1	propionate					1212:1221	the health-related propionate	1193:1221	the health-related propionate	1193:1221	At the metabolic level, while decreasing branched-chain fatty acids, 2'-FL strongly increased acetate production together with increases in the health-related propionate and butyrate whilst gas production only mildly increased.
33668823	3	71	theme	BF	690:691	arg1	infants					694:700	3-month-old breastfed (BF) infants	667:700	3-month-old breastfed (BF) infants as well as 2-3 year old toddlers	667:733	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	5	72	theme	immediate	895:903	arg1	increase					905:912	the strong and immediate increase	880:912	the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®	880:1050	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	5	72	theme	immediate	895:903	arg1	finding					868:874	A key finding	862:874	A key finding	862:874	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	6	73	theme	metabolic	1060:1068	arg1	level					1070:1074	the metabolic level	1056:1074	the metabolic level	1056:1074	At the metabolic level, while decreasing branched-chain fatty acids, 2'-FL strongly increased acetate production together with increases in the health-related propionate and butyrate whilst gas production only mildly increased.
33668823	7	74	theme	bifidogenic	1513:1523	arg1	effect					1525:1530	the bifidogenic effect	1509:1530	the bifidogenic effect observed	1509:1539	Notably, consistently lower gas production was observed with 2'-FL fermentation as compared to lactose, suggesting that reduced discomfort during the dynamic microbiome establishment in early life may be an advantage along with the bifidogenic effect observed.
33668823	3	75	theme	gut	440:442	arg1	fermentation					455:466	the gut microbiota fermentation	436:466	the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL)	436:498	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	1	76	theme	breast	191:196	arg1	milk					198:201	breast milk	191:201	breast milk	191:201	Because of the recognized health benefits of breast milk, it is recommended as the sole nutrition source during the first 6 months of life.
33668823	5	77	from	increase	905:912	arg1	abundance					930:938	the relative abundance	917:938	the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®	917:1050	A key finding was the strong and immediate increase in the relative abundance of Bifidobacteriaceae following 2'-FL fermentation by both the BF infant and toddler microbiota in the M-SHIME®.
33668823	4	78	theme	donors	787:792	arg1	screening					769:777	the screening	765:777	the screening of five donors for each group	765:807	The short-term model allowed the screening of five donors for each group and provided supportive data for the M-SHIME® study.
33668823	3	79	theme	breastfed	679:687	arg1	infants					694:700	3-month-old breastfed (BF) infants	667:700	3-month-old breastfed (BF) infants as well as 2-3 year old toddlers	667:733	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	1	80	theme	milk	198:201	arg1	benefits					179:186	the recognized health benefits	157:186	the recognized health benefits of breast milk	157:201	Because of the recognized health benefits of breast milk, it is recommended as the sole nutrition source during the first 6 months of life.
33668823	3	81	theme	in	511:512	arg1	models					520:525	two in vitro models	507:525	two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers	507:733	Here, we investigated the gut microbiota fermentation of HMO 2'fucosyllactose (2'-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2-3 year old toddlers.
33668823	2	82	theme	bioactive	296:304	arg1	components					306:315	the bioactive components	292:315	the bioactive components	292:315	Among the bioactive components are human milk oligosaccharides (HMOs) that exert part of their activity via the gut microbiota.
33668823	6	83	theme	gas	1243:1245	arg1	production					1247:1256	gas production	1243:1256	gas production	1243:1256	At the metabolic level, while decreasing branched-chain fatty acids, 2'-FL strongly increased acetate production together with increases in the health-related propionate and butyrate whilst gas production only mildly increased.
32304788	3	0	from	values	636:641	arg1	elongation					616:625	elongation	616:625	elongation	616:625	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	3	0	from	values	636:641	arg1	strength					603:610	tensile strength	595:610	tensile strength	595:610	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	3	1	theme	hydrogen	969:976	arg1	bonds					978:982	hydrogen bonds	969:982	hydrogen bonds	969:982	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	6	2	theme	packaging	1345:1353	arg1	materials					1355:1363	food packaging materials	1340:1363	food packaging materials	1340:1363	The SA-gelatin-GO ternary composite films provide a good select for food packaging materials, especially the materials that require high strength and fine ductility.
32304788	6	2	theme	packaging	1345:1353	arg1	materials					1381:1389	the materials	1377:1389	the materials that require high strength and fine ductility	1377:1435	The SA-gelatin-GO ternary composite films provide a good select for food packaging materials, especially the materials that require high strength and fine ductility.
32304788	2	3	theme	structural	443:452	arg1	morphology					431:440	the morphology	427:440	the morphology	427:440	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	2	4	from	content	416:422	arg1	properties					526:535	the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties	427:535	the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films	427:554	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	3	5	theme	bonds	978:982	arg1	interaction					954:964	the interaction	950:964	the interaction of hydrogen bonds	950:982	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	3	5	theme	bonds	978:982	arg1	dispersibility					997:1010	the good dispersibility	988:1010	the good dispersibility of GO in the film matrix	988:1035	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	3	6	with	film	660:663	arg1	%					673:673	0.5%	670:673	0.5% GO content	670:684	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	3	7	theme	film	1025:1028	arg1	matrix					1030:1035	the film matrix	1021:1035	the film matrix	1021:1035	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	0	8	theme	alginate-gelatin	95:110	arg1	ratio					119:123	sodium alginate-gelatin weight ratio	88:123	sodium alginate-gelatin weight ratio	88:123	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.
32304788	3	9	theme	composite	650:658	arg1	film					660:663	the composite film	646:663	the composite film with 0.5% GO content	646:684	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	2	10	theme	films	550:554	arg1	properties					526:535	the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties	427:535	the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films	427:554	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	0	11	theme	sodium	88:93	arg1	ratio					119:123	sodium alginate-gelatin weight ratio	88:123	sodium alginate-gelatin weight ratio	88:123	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.
32304788	1	12	theme	SA-gelatin-GO	323:335	arg1	films					355:359	SA-gelatin-GO ternary composite films	323:359	SA-gelatin-GO ternary composite films	323:359	This study aimed to simultaneously enhance the strength and ductility of films by adding graphene oxide (GO) into the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films.
32304788	2	13	theme	composite	540:548	arg1	films					550:554	composite films	540:554	composite films	540:554	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	3	14	theme	SA-gelatin	916:925	arg1	due					943:945	due	943:945	due	943:945	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	3	14	theme	SA-gelatin	916:925	arg1	film					927:930	the SA-gelatin film	912:930	the SA-gelatin film	912:930	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	3	15	dep	%	673:673	arg1	GO					675:676	GO	675:676	GO content	675:684	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	0	16	theme	ratio	119:123	arg1	Effects					77:83	Effects	77:83	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.	0:151	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.
32304788	1	17	theme	ternary	337:343	arg1	films					355:359	SA-gelatin-GO ternary composite films	323:359	SA-gelatin-GO ternary composite films	323:359	This study aimed to simultaneously enhance the strength and ductility of films by adding graphene oxide (GO) into the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films.
32304788	3	18	theme	good	992:995	arg1	dispersibility					997:1010	the good dispersibility	988:1010	the good dispersibility of GO in the film matrix	988:1035	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	3	19	theme	film	927:930	arg1	ductility					899:907	ductility	899:907	ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix	899:1035	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	3	19	theme	film	927:930	arg1	strength					886:893	the strength	882:893	the strength	882:893	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	0	20	theme	weight	112:117	arg1	ratio					119:123	sodium alginate-gelatin weight ratio	88:123	sodium alginate-gelatin weight ratio	88:123	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.
32304788	1	21	theme	composite	345:353	arg1	films					355:359	SA-gelatin-GO ternary composite films	323:359	SA-gelatin-GO ternary composite films	323:359	This study aimed to simultaneously enhance the strength and ductility of films by adding graphene oxide (GO) into the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films.
32304788	4	22	theme	films	1078:1082	arg1	hydrophobicity					1050:1063	The surface hydrophobicity	1038:1063	The surface hydrophobicity of composite films	1038:1082	The surface hydrophobicity of composite films increased first and then decreased with increasing GO content.
32304788	2	23	theme	GO	413:414	arg1	content					416:422	the GO content	409:422	the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films	409:554	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	6	24	theme	fine	1422:1425	arg1	ductility					1427:1435	fine ductility	1422:1435	fine ductility	1422:1435	The SA-gelatin-GO ternary composite films provide a good select for food packaging materials, especially the materials that require high strength and fine ductility.
32304788	0	25	theme	composite	8:16	arg1	films					18:22	Ternary composite films	0:22	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.	0:151	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.
32304788	3	26	from	dispersibility	997:1010	arg1	matrix					1030:1035	the film matrix	1021:1035	the film matrix	1021:1035	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	6	27	theme	food	1340:1343	arg1	materials					1355:1363	food packaging materials	1340:1363	food packaging materials	1340:1363	The SA-gelatin-GO ternary composite films provide a good select for food packaging materials, especially the materials that require high strength and fine ductility.
32304788	6	27	theme	food	1340:1343	arg1	materials					1381:1389	the materials	1377:1389	the materials that require high strength and fine ductility	1377:1435	The SA-gelatin-GO ternary composite films provide a good select for food packaging materials, especially the materials that require high strength and fine ductility.
32304788	0	28	theme	Ternary	0:6	arg1	films					18:22	Ternary composite films	0:22	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.	0:151	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.
32304788	5	29	theme	GO	1250:1251	arg1	content					1253:1259	the GO content	1246:1259	the GO content	1246:1259	In addition, the hygroscopicity of composite films reduced due to the GO addition, especially when the GO content was 0.25%.
32304788	5	29	theme	GO	1250:1251	arg1	%					1269:1269	0.25%	1265:1269	0.25%	1265:1269	In addition, the hygroscopicity of composite films reduced due to the GO addition, especially when the GO content was 0.25%.
32304788	0	30	theme	graphene	129:136	arg1	content					144:150	graphene oxide content	129:150	graphene oxide content	129:150	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.
32304788	3	31	theme	%	857:857	arg1	content					843:849	the content	839:849	the content of 0.5%	839:857	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	2	32	theme	vapor	486:490	arg1	barrier					492:498	water vapor barrier	480:498	water vapor barrier	480:498	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	4	33	theme	surface	1042:1048	arg1	hydrophobicity					1050:1063	The surface hydrophobicity	1038:1063	The surface hydrophobicity of composite films	1038:1082	The surface hydrophobicity of composite films increased first and then decreased with increasing GO content.
32304788	1	34	theme	sodium	271:276	arg1	system					305:310	the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films	267:359	the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films	267:359	This study aimed to simultaneously enhance the strength and ductility of films by adding graphene oxide (GO) into the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films.
32304788	2	35	theme	hygroscopic	501:511	arg1	morphology					431:440	the morphology	427:440	the morphology	427:440	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	6	36	theme	composite	1298:1306	arg1	films					1308:1312	The SA-gelatin-GO ternary composite films	1272:1312	The SA-gelatin-GO ternary composite films	1272:1312	The SA-gelatin-GO ternary composite films provide a good select for food packaging materials, especially the materials that require high strength and fine ductility.
32304788	4	37	dep	increased	1084:1092	arg1	decreased					1109:1117	decreased	1109:1117	increased first and then decreased with increasing GO content	1084:1144	The surface hydrophobicity of composite films increased first and then decreased with increasing GO content.
32304788	2	38	theme	weight	392:397	arg1	ratio					399:403	the SA/gelatin weight ratio	377:403	the SA/gelatin weight ratio	377:403	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	0	39	theme	enhanced	44:51	arg1	strength					53:60	simultaneously enhanced strength	29:60	simultaneously enhanced strength	29:60	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.
32304788	1	40	theme	alginate	278:285	arg1	system					305:310	the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films	267:359	the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films	267:359	This study aimed to simultaneously enhance the strength and ductility of films by adding graphene oxide (GO) into the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films.
32304788	0	41	theme	content	144:150	arg1	Effects					77:83	Effects	77:83	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.	0:151	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.
32304788	4	42	dep	content	1138:1144	arg1	GO					1135:1136	GO	1135:1136	GO	1135:1136	The surface hydrophobicity of composite films increased first and then decreased with increasing GO content.
32304788	3	43	theme	GO	1015:1016	arg1	interaction					954:964	the interaction	950:964	the interaction of hydrogen bonds	950:982	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	3	43	theme	GO	1015:1016	arg1	dispersibility					997:1010	the good dispersibility	988:1010	the good dispersibility of GO in the film matrix	988:1035	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	5	44	theme	GO	1217:1218	arg1	addition					1220:1227	the GO addition	1213:1227	the GO addition	1213:1227	In addition, the hygroscopicity of composite films reduced due to the GO addition, especially when the GO content was 0.25%.
32304788	2	45	theme	SA/gelatin	381:390	arg1	ratio					399:403	the SA/gelatin weight ratio	377:403	the SA/gelatin weight ratio	377:403	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	2	46	theme	morphology	431:440	arg1	properties					526:535	the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties	427:535	the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films	427:554	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	3	47	from	interaction	954:964	arg1	matrix					1030:1035	the film matrix	1021:1035	the film matrix	1021:1035	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	0	48	theme	oxide	138:142	arg1	content					144:150	graphene oxide content	129:150	graphene oxide content	129:150	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.
32304788	3	49	theme	tensile	595:601	arg1	strength					603:610	tensile strength	595:610	tensile strength	595:610	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	2	50	theme	hydrophobic	467:477	arg1	morphology					431:440	the morphology	427:440	the morphology	427:440	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	6	51	theme	ternary	1290:1296	arg1	films					1308:1312	The SA-gelatin-GO ternary composite films	1272:1312	The SA-gelatin-GO ternary composite films	1272:1312	The SA-gelatin-GO ternary composite films provide a good select for food packaging materials, especially the materials that require high strength and fine ductility.
32304788	1	52	theme	SA	288:289	arg1	system					305:310	the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films	267:359	the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films	267:359	This study aimed to simultaneously enhance the strength and ductility of films by adding graphene oxide (GO) into the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films.
32304788	2	53	theme	water	480:484	arg1	barrier					492:498	water vapor barrier	480:498	water vapor barrier	480:498	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	0	54	with	films	18:22	arg1	ductility					66:74	ductility	66:74	ductility	66:74	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.
32304788	0	54	with	films	18:22	arg1	strength					53:60	simultaneously enhanced strength	29:60	simultaneously enhanced strength	29:60	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.
32304788	2	55	theme	barrier	492:498	arg1	properties					526:535	the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties	427:535	the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films	427:554	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	3	56	theme	film	660:663	arg1	values					636:641	break values	630:641	break values of the composite film with 0.5% GO content	630:684	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	3	57	dep	%	757:757	arg1	to					749:750	to	749:750	to	749:750	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	1	58	theme	-gelatin	291:298	arg1	system					305:310	the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films	267:359	the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films	267:359	This study aimed to simultaneously enhance the strength and ductility of films by adding graphene oxide (GO) into the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films.
32304788	2	59	theme	optical	518:524	arg1	properties					526:535	the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties	427:535	the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films	427:554	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	2	60	from	effects	366:372	arg1	properties					526:535	the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties	427:535	the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films	427:554	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	3	61	theme	SA-gelatin	792:801	arg1	film					803:806	the SA-gelatin film	788:806	the SA-gelatin film without GO	788:817	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	1	62	theme	films	226:230	arg1	ductility					213:221	ductility	213:221	ductility	213:221	This study aimed to simultaneously enhance the strength and ductility of films by adding graphene oxide (GO) into the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films.
32304788	1	62	theme	films	226:230	arg1	strength					200:207	strength	200:207	strength	200:207	This study aimed to simultaneously enhance the strength and ductility of films by adding graphene oxide (GO) into the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films.
32304788	6	63	dep	good	1324:1327	arg1	select					1329:1334	select	1329:1334	select for food packaging materials, especially the materials that require high strength and fine ductility	1329:1435	The SA-gelatin-GO ternary composite films provide a good select for food packaging materials, especially the materials that require high strength and fine ductility.
32304788	1	64	dep	oxide	251:255	arg1	GO					258:259	GO	258:259	GO	258:259	This study aimed to simultaneously enhance the strength and ductility of films by adding graphene oxide (GO) into the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films.
32304788	0	65	dep	films	18:22	arg1	Effects					77:83	Effects	77:83	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.	0:151	Ternary composite films with simultaneously enhanced strength and ductility: Effects of sodium alginate-gelatin weight ratio and graphene oxide content.
32304788	6	66	theme	high	1404:1407	arg1	strength					1409:1416	high strength	1404:1416	high strength	1404:1416	The SA-gelatin-GO ternary composite films provide a good select for food packaging materials, especially the materials that require high strength and fine ductility.
32304788	5	67	theme	films	1192:1196	arg1	hygroscopicity					1164:1177	the hygroscopicity	1160:1177	the hygroscopicity of composite films	1160:1196	In addition, the hygroscopicity of composite films reduced due to the GO addition, especially when the GO content was 0.25%.
32304788	3	68	from	matrix	1030:1035	arg1	interaction					954:964	the interaction	950:964	the interaction of hydrogen bonds	950:982	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	3	68	from	matrix	1030:1035	arg1	dispersibility					997:1010	the good dispersibility	988:1010	the good dispersibility of GO in the film matrix	988:1035	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	3	69	theme	break	630:634	arg1	values					636:641	break values	630:641	break values of the composite film with 0.5% GO content	630:684	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	1	70	dep	strength	200:207	arg1	the					196:198	the	196:198	the	196:198	This study aimed to simultaneously enhance the strength and ductility of films by adding graphene oxide (GO) into the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films.
32304788	2	71	theme	ratio	399:403	arg1	effects					366:372	The effects	362:372	The effects of the SA/gelatin weight ratio	362:403	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	2	71	theme	ratio	399:403	arg1	content					416:422	the GO content	409:422	the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films	409:554	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	6	72	theme	SA-gelatin-GO	1276:1288	arg1	films					1308:1312	The SA-gelatin-GO ternary composite films	1272:1312	The SA-gelatin-GO ternary composite films	1272:1312	The SA-gelatin-GO ternary composite films provide a good select for food packaging materials, especially the materials that require high strength and fine ductility.
32304788	5	73	theme	composite	1182:1190	arg1	films					1192:1196	composite films	1182:1196	composite films	1182:1196	In addition, the hygroscopicity of composite films reduced due to the GO addition, especially when the GO content was 0.25%.
32304788	2	74	theme	mechanical	455:464	arg1	morphology					431:440	the morphology	427:440	the morphology	427:440	The effects of the SA/gelatin weight ratio and the GO content on the morphology, structural, mechanical, hydrophobic, water vapor barrier, hygroscopic, and optical properties of composite films were investigated.
32304788	1	75	theme	film	300:303	arg1	system					305:310	the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films	267:359	the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films	267:359	This study aimed to simultaneously enhance the strength and ductility of films by adding graphene oxide (GO) into the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films.
32304788	3	76	theme	%	747:747	arg1	%					757:757	20.19% to 25.75%	742:757	20.19% to 25.75%	742:757	Results showed that tensile strength and elongation at break values of the composite film with 0.5% GO content were significantly improved from 37.00 to 48.01 MPa and 20.19% to 25.75%, respectively, compared with the SA-gelatin film without GO, suggesting GO with the content of 0.5% simultaneously enhance the strength and ductility of the SA-gelatin film, which was due to the interaction of hydrogen bonds and the good dispersibility of GO in the film matrix.
32304788	4	77	theme	composite	1068:1076	arg1	films					1078:1082	composite films	1068:1082	composite films	1068:1082	The surface hydrophobicity of composite films increased first and then decreased with increasing GO content.
32304788	1	78	theme	graphene	242:249	arg1	oxide					251:255	graphene oxide	242:255	graphene oxide (GO)	242:260	This study aimed to simultaneously enhance the strength and ductility of films by adding graphene oxide (GO) into the sodium alginate (SA)-gelatin film system to prepare SA-gelatin-GO ternary composite films.
34166902	1	0	theme	Dual	150:153	arg1	strategy					265:272	an effective strategy	252:272	an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI)	252:381	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	1	0	theme	Dual	150:153	arg1	modification					155:166	Dual modification	150:166	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled	150:247	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	9	1	theme	modification	1462:1473	arg1	sequence					1475:1482	the modification sequence	1458:1482	the modification sequence	1458:1482	This study highlights the importance of the modification sequence for the dual-modified nZVI properties and provides support for the synthesis method.
34166902	8	2	contain	has	1324:1326	arg2	reactivity					1335:1344	higher reactivity	1328:1344	higher reactivity	1328:1344	These findings explain why postsulfidated and one-pot nZVI has higher reactivity and electron selectivity, while presulfidated nZVI has higher mobility.
34166902	8	2	contain	has	1324:1326	arg1	nZVI					1319:1322	postsulfidated and one-pot nZVI	1292:1322	postsulfidated and one-pot nZVI	1292:1322	These findings explain why postsulfidated and one-pot nZVI has higher reactivity and electron selectivity, while presulfidated nZVI has higher mobility.
34166902	8	2	contain	has	1324:1326	arg2	selectivity					1359:1369	electron selectivity	1350:1369	electron selectivity	1350:1369	These findings explain why postsulfidated and one-pot nZVI has higher reactivity and electron selectivity, while presulfidated nZVI has higher mobility.
34166902	4	3	theme	FeS	806:808	arg1	shell					810:814	the FeS shell	802:814	the FeS shell	802:814	However, CMC can peel off the FeS shell, resulting in a low sulfur content in nZVI.
34166902	5	4	theme	reduced	1008:1014	arg1	mobility					1016:1023	reduced mobility	1008:1023	reduced mobility of nZVI	1008:1031	The Na+ of the sulfidation reagent and the Fe2+ dissolved from the FeS precipitates reduce the CMC viscosity, causing accelerated sedimentation and reduced mobility of nZVI.
34166902	0	5	from	Effect	0:5	arg1	selectivity					64:74	electron selectivity	55:74	electron selectivity	55:74	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.
34166902	0	5	from	Effect	0:5	arg1	mobility					81:88	mobility	81:88	mobility	81:88	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.
34166902	0	5	from	Effect	0:5	arg1	reactivity					43:52	reactivity	43:52	reactivity	43:52	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.
34166902	8	6	contain	has	1397:1399	arg1	nZVI					1392:1395	presulfidated nZVI	1378:1395	presulfidated nZVI	1378:1395	These findings explain why postsulfidated and one-pot nZVI has higher reactivity and electron selectivity, while presulfidated nZVI has higher mobility.
34166902	8	6	contain	has	1397:1399	arg2	mobility					1408:1415	higher mobility	1401:1415	higher mobility	1401:1415	These findings explain why postsulfidated and one-pot nZVI has higher reactivity and electron selectivity, while presulfidated nZVI has higher mobility.
34166902	5	7	theme	sulfidation	875:885	arg1	reagent					887:893	the sulfidation reagent	871:893	the sulfidation reagent	871:893	The Na+ of the sulfidation reagent and the Fe2+ dissolved from the FeS precipitates reduce the CMC viscosity, causing accelerated sedimentation and reduced mobility of nZVI.
34166902	1	8	theme	effective	255:263	arg1	modification					155:166	Dual modification	150:166	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled	150:247	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	1	8	theme	effective	255:263	arg1	strategy					265:272	an effective strategy	252:272	an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI)	252:381	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	2	9	theme	suspensions	507:517	arg1	composition					427:437	suspension composition	416:437	suspension composition	416:437	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	2	9	theme	suspensions	507:517	arg1	sedimentation					471:483	sedimentation	471:483	sedimentation	471:483	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	2	9	theme	suspensions	507:517	arg1	potential					456:464	zeta potential	451:464	zeta potential	451:464	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	2	9	theme	suspensions	507:517	arg1	viscosity					440:448	viscosity	440:448	viscosity	440:448	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	2	9	theme	suspensions	507:517	arg1	content					407:413	sulfur content	400:413	sulfur content	400:413	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	1	10	theme	nanoscale	350:358	arg1	nZVI					377:380	nZVI	377:380	nZVI	377:380	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	1	10	theme	nanoscale	350:358	arg1	iron					371:374	nanoscale zerovalent iron	350:374	nanoscale zerovalent iron (nZVI)	350:381	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	5	11	theme	reagent	887:893	arg1	Fe2+					903:906	the Fe2+	899:906	the Fe2+ dissolved from the FeS precipitates	899:942	The Na+ of the sulfidation reagent and the Fe2+ dissolved from the FeS precipitates reduce the CMC viscosity, causing accelerated sedimentation and reduced mobility of nZVI.
34166902	5	11	theme	reagent	887:893	arg1	Na+					864:866	The Na+	860:866	The Na+ of the sulfidation reagent	860:893	The Na+ of the sulfidation reagent and the Fe2+ dissolved from the FeS precipitates reduce the CMC viscosity, causing accelerated sedimentation and reduced mobility of nZVI.
34166902	0	12	theme	sulfidated	93:102	arg1	iron					144:147	sulfidated and CMC-stabilized nanoscale zerovalent iron	93:147	sulfidated and CMC-stabilized nanoscale zerovalent iron	93:147	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.
34166902	1	13	theme	zerovalent	360:369	arg1	nZVI					377:380	nZVI	377:380	nZVI	377:380	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	1	13	theme	zerovalent	360:369	arg1	iron					371:374	nanoscale zerovalent iron	350:374	nanoscale zerovalent iron (nZVI)	350:381	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	2	14	theme	sulfur	400:405	arg1	content					407:413	sulfur content	400:413	sulfur content	400:413	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	8	15	theme	one-pot	1311:1317	arg1	nZVI					1319:1322	postsulfidated and one-pot nZVI	1292:1322	postsulfidated and one-pot nZVI	1292:1322	These findings explain why postsulfidated and one-pot nZVI has higher reactivity and electron selectivity, while presulfidated nZVI has higher mobility.
34166902	2	16	theme	dual-modified	488:500	arg1	suspensions					507:517	dual-modified nZVI suspensions	488:517	dual-modified nZVI suspensions synthesized in different modification sequences	488:565	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	1	17	theme	iron	371:374	arg1	mobility					338:345	mobility	338:345	mobility	338:345	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	1	17	theme	iron	371:374	arg1	selectivity					309:319	the insufficient electron selectivity	283:319	the insufficient electron selectivity	283:319	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	1	17	theme	iron	371:374	arg1	reactivity					322:331	reactivity	322:331	reactivity	322:331	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	6	18	theme	Fe2+	1078:1081	arg1	concentration					1083:1095	the free Fe2+ concentration	1069:1095	the free Fe2+ concentration	1069:1095	The peeled off FeS shell increases the free Fe2+ concentration, thereby enhancing nitrobenzene reduction.
34166902	2	19	theme	nZVI	502:505	arg1	suspensions					507:517	dual-modified nZVI suspensions	488:517	dual-modified nZVI suspensions synthesized in different modification sequences	488:565	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	9	20	theme	dual-modified	1492:1504	arg1	properties					1511:1520	the dual-modified nZVI properties	1488:1520	the dual-modified nZVI properties	1488:1520	This study highlights the importance of the modification sequence for the dual-modified nZVI properties and provides support for the synthesis method.
34166902	3	21	theme	CMC	710:712	arg1	coating					714:720	the CMC coating	706:720	the CMC coating on the surface	706:735	The results show that the dissolved CMC does not take up S2-, and the CMC coating on the surface does not block S2- during sulfidation.
34166902	3	22	from	coating	714:720	arg1	surface					729:735	the surface	725:735	the surface	725:735	The results show that the dissolved CMC does not take up S2-, and the CMC coating on the surface does not block S2- during sulfidation.
34166902	6	23	theme	free	1073:1076	arg1	concentration					1083:1095	the free Fe2+ concentration	1069:1095	the free Fe2+ concentration	1069:1095	The peeled off FeS shell increases the free Fe2+ concentration, thereby enhancing nitrobenzene reduction.
34166902	1	24	theme	carboxymethyl	177:189	arg1	stabilization					207:219	carboxymethyl cellulose (CMC) stabilization	177:219	carboxymethyl cellulose (CMC) stabilization	177:219	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	2	25	theme	different	534:542	arg1	sequences					557:565	different modification sequences	534:565	different modification sequences	534:565	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	2	26	theme	sulfidation	609:619	arg1	reagent					621:627	the sulfidation reagent	605:627	the sulfidation reagent	605:627	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	1	27	theme	cellulose	191:199	arg1	stabilization					207:219	carboxymethyl cellulose (CMC) stabilization	177:219	carboxymethyl cellulose (CMC) stabilization	177:219	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	2	28	theme	suspension	416:425	arg1	composition					427:437	suspension composition	416:437	suspension composition	416:437	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	0	29	theme	CMC-stabilized	108:121	arg1	iron					144:147	sulfidated and CMC-stabilized nanoscale zerovalent iron	93:147	sulfidated and CMC-stabilized nanoscale zerovalent iron	93:147	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.
34166902	9	30	theme	synthesis	1551:1559	arg1	method					1561:1566	the synthesis method	1547:1566	the synthesis method	1547:1566	This study highlights the importance of the modification sequence for the dual-modified nZVI properties and provides support for the synthesis method.
34166902	8	31	theme	electron	1350:1357	arg1	selectivity					1359:1369	electron selectivity	1350:1369	electron selectivity	1350:1369	These findings explain why postsulfidated and one-pot nZVI has higher reactivity and electron selectivity, while presulfidated nZVI has higher mobility.
34166902	7	32	theme	nZVI	1244:1247	arg1	dispersibility					1249:1262	the increased nZVI dispersibility	1230:1262	the increased nZVI dispersibility	1230:1262	Additionally, CMC promotes nitrobenzene reduction and hydrogen evolution reactions due to the increased nZVI dispersibility.
34166902	2	33	theme	modification	544:555	arg1	sequences					557:565	different modification sequences	534:565	different modification sequences	534:565	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	5	34	theme	accelerated	978:988	arg1	sedimentation					990:1002	accelerated sedimentation	978:1002	accelerated sedimentation	978:1002	The Na+ of the sulfidation reagent and the Fe2+ dissolved from the FeS precipitates reduce the CMC viscosity, causing accelerated sedimentation and reduced mobility of nZVI.
34166902	8	35	theme	higher	1328:1333	arg1	reactivity					1335:1344	higher reactivity	1328:1344	higher reactivity	1328:1344	These findings explain why postsulfidated and one-pot nZVI has higher reactivity and electron selectivity, while presulfidated nZVI has higher mobility.
34166902	9	36	theme	nZVI	1506:1509	arg1	properties					1511:1520	the dual-modified nZVI properties	1488:1520	the dual-modified nZVI properties	1488:1520	This study highlights the importance of the modification sequence for the dual-modified nZVI properties and provides support for the synthesis method.
34166902	1	37	theme	CMC	202:204	arg1	stabilization					207:219	carboxymethyl cellulose (CMC) stabilization	177:219	carboxymethyl cellulose (CMC) stabilization	177:219	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	1	38	theme	insufficient	287:298	arg1	selectivity					309:319	the insufficient electron selectivity	283:319	the insufficient electron selectivity	283:319	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	0	39	theme	zerovalent	133:142	arg1	iron					144:147	sulfidated and CMC-stabilized nanoscale zerovalent iron	93:147	sulfidated and CMC-stabilized nanoscale zerovalent iron	93:147	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.
34166902	8	40	theme	higher	1401:1406	arg1	mobility					1408:1415	higher mobility	1401:1415	higher mobility	1401:1415	These findings explain why postsulfidated and one-pot nZVI has higher reactivity and electron selectivity, while presulfidated nZVI has higher mobility.
34166902	5	41	theme	FeS	927:929	arg1	precipitates					931:942	the FeS precipitates	923:942	the FeS precipitates	923:942	The Na+ of the sulfidation reagent and the Fe2+ dissolved from the FeS precipitates reduce the CMC viscosity, causing accelerated sedimentation and reduced mobility of nZVI.
34166902	2	42	theme	zeta	451:454	arg1	potential					456:464	zeta potential	451:464	zeta potential	451:464	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	1	43	theme	electron	300:307	arg1	selectivity					309:319	the insufficient electron selectivity	283:319	the insufficient electron selectivity	283:319	Dual modification in which carboxymethyl cellulose (CMC) stabilization and sulfidation are coupled is an effective strategy to solve the insufficient electron selectivity, reactivity, and mobility of nanoscale zerovalent iron (nZVI).
34166902	0	44	theme	sequence	27:34	arg1	Effect					0:5	Effect	0:5	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.	0:148	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.
34166902	0	45	theme	modification	14:25	arg1	sequence					27:34	the modification sequence	10:34	the modification sequence	10:34	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.
34166902	7	46	theme	increased	1234:1242	arg1	dispersibility					1249:1262	the increased nZVI dispersibility	1230:1262	the increased nZVI dispersibility	1230:1262	Additionally, CMC promotes nitrobenzene reduction and hydrogen evolution reactions due to the increased nZVI dispersibility.
34166902	4	47	dep	shell	810:814	arg1	off					798:800	off	798:800	off	798:800	However, CMC can peel off the FeS shell, resulting in a low sulfur content in nZVI.
34166902	4	48	from	content	843:849	arg1	nZVI					854:857	nZVI	854:857	nZVI	854:857	However, CMC can peel off the FeS shell, resulting in a low sulfur content in nZVI.
34166902	2	49	dep	content	407:413	arg1	the					396:398	the	396:398	the	396:398	We compared the sulfur content, suspension composition, viscosity, zeta potential, and sedimentation of dual-modified nZVI suspensions synthesized in different modification sequences to analyze the interaction among CMC, the sulfidation reagent, and nZVI.
34166902	5	50	theme	nZVI	1028:1031	arg1	sedimentation					990:1002	accelerated sedimentation	978:1002	accelerated sedimentation	978:1002	The Na+ of the sulfidation reagent and the Fe2+ dissolved from the FeS precipitates reduce the CMC viscosity, causing accelerated sedimentation and reduced mobility of nZVI.
34166902	5	50	theme	nZVI	1028:1031	arg1	mobility					1016:1023	reduced mobility	1008:1023	reduced mobility of nZVI	1008:1031	The Na+ of the sulfidation reagent and the Fe2+ dissolved from the FeS precipitates reduce the CMC viscosity, causing accelerated sedimentation and reduced mobility of nZVI.
34166902	6	51	theme	FeS	1049:1051	arg1	shell					1053:1057	The peeled off FeS shell	1034:1057	The peeled off FeS shell	1034:1057	The peeled off FeS shell increases the free Fe2+ concentration, thereby enhancing nitrobenzene reduction.
34166902	0	52	theme	nanoscale	123:131	arg1	iron					144:147	sulfidated and CMC-stabilized nanoscale zerovalent iron	93:147	sulfidated and CMC-stabilized nanoscale zerovalent iron	93:147	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.
34166902	0	53	theme	iron	144:147	arg1	selectivity					64:74	electron selectivity	55:74	electron selectivity	55:74	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.
34166902	0	53	theme	iron	144:147	arg1	mobility					81:88	mobility	81:88	mobility	81:88	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.
34166902	0	53	theme	iron	144:147	arg1	reactivity					43:52	reactivity	43:52	reactivity	43:52	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.
34166902	5	54	theme	CMC	955:957	arg1	viscosity					959:967	the CMC viscosity	951:967	the CMC viscosity	951:967	The Na+ of the sulfidation reagent and the Fe2+ dissolved from the FeS precipitates reduce the CMC viscosity, causing accelerated sedimentation and reduced mobility of nZVI.
34166902	4	55	theme	sulfur	836:841	arg1	content					843:849	a low sulfur content	830:849	a low sulfur content in nZVI	830:857	However, CMC can peel off the FeS shell, resulting in a low sulfur content in nZVI.
34166902	3	56	theme	dissolved	666:674	arg1	CMC					676:678	the dissolved CMC	662:678	the dissolved CMC	662:678	The results show that the dissolved CMC does not take up S2-, and the CMC coating on the surface does not block S2- during sulfidation.
34166902	8	57	theme	presulfidated	1378:1390	arg1	nZVI					1392:1395	presulfidated nZVI	1378:1395	presulfidated nZVI	1378:1395	These findings explain why postsulfidated and one-pot nZVI has higher reactivity and electron selectivity, while presulfidated nZVI has higher mobility.
34166902	6	58	theme	peeled	1038:1043	arg1	shell					1053:1057	The peeled off FeS shell	1034:1057	The peeled off FeS shell	1034:1057	The peeled off FeS shell increases the free Fe2+ concentration, thereby enhancing nitrobenzene reduction.
34166902	4	59	theme	low	832:834	arg1	content					843:849	a low sulfur content	830:849	a low sulfur content in nZVI	830:857	However, CMC can peel off the FeS shell, resulting in a low sulfur content in nZVI.
34166902	8	60	theme	postsulfidated	1292:1305	arg1	nZVI					1319:1322	postsulfidated and one-pot nZVI	1292:1322	postsulfidated and one-pot nZVI	1292:1322	These findings explain why postsulfidated and one-pot nZVI has higher reactivity and electron selectivity, while presulfidated nZVI has higher mobility.
34166902	9	61	theme	sequence	1475:1482	arg1	importance					1444:1453	the importance	1440:1453	the importance of the modification sequence for the dual-modified nZVI properties	1440:1520	This study highlights the importance of the modification sequence for the dual-modified nZVI properties and provides support for the synthesis method.
34166902	7	62	theme	evolution	1203:1211	arg1	reactions					1213:1221	hydrogen evolution reactions	1194:1221	hydrogen evolution reactions	1194:1221	Additionally, CMC promotes nitrobenzene reduction and hydrogen evolution reactions due to the increased nZVI dispersibility.
34166902	0	63	theme	electron	55:62	arg1	selectivity					64:74	electron selectivity	55:74	electron selectivity	55:74	Effect of the modification sequence on the reactivity, electron selectivity, and mobility of sulfidated and CMC-stabilized nanoscale zerovalent iron.
34166902	6	64	theme	nitrobenzene	1116:1127	arg1	reduction					1129:1137	nitrobenzene reduction	1116:1137	nitrobenzene reduction	1116:1137	The peeled off FeS shell increases the free Fe2+ concentration, thereby enhancing nitrobenzene reduction.
34166902	7	65	theme	hydrogen	1194:1201	arg1	reactions					1213:1221	hydrogen evolution reactions	1194:1221	hydrogen evolution reactions	1194:1221	Additionally, CMC promotes nitrobenzene reduction and hydrogen evolution reactions due to the increased nZVI dispersibility.
34166902	7	66	theme	nitrobenzene	1167:1178	arg1	reduction					1180:1188	nitrobenzene reduction	1167:1188	nitrobenzene reduction	1167:1188	Additionally, CMC promotes nitrobenzene reduction and hydrogen evolution reactions due to the increased nZVI dispersibility.
32173440	0	0	theme	mixture	100:106	arg1	design					108:113	mixture design	100:113	mixture design	100:113	Gelatin-chitosan-pectin films incorporated with rosemary essential oil: Optimized formulation using mixture design and response surface methodology.
32173440	2	1	theme	%	469:469	arg1	chitosan					471:478	10.0% chitosan	465:478	10.0% chitosan	465:478	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	1	2	theme	study	165:169	arg1	aim					153:155	The aim	149:155	The aim of this study	149:169	The aim of this study was to optimize the mechanical and texture properties of edible film improving its antibacterial property after adding rosemary essential oil (REO) using a Doehlert matrix.
32173440	1	3	theme	antibacterial	254:266	arg1	property					268:275	its antibacterial property	250:275	its antibacterial property	250:275	The aim of this study was to optimize the mechanical and texture properties of edible film improving its antibacterial property after adding rosemary essential oil (REO) using a Doehlert matrix.
32173440	2	4	theme	10.0	465:468	arg1	%					469:469	%	469:469	%	469:469	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	4	5	theme	antibacterial	670:682	arg1	activity					684:691	The antibacterial activity	666:691	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli	666:830	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli was enhanced when applying a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties.
32173440	5	6	theme	structural	957:966	arg1	properties					989:998	The structural, optical and barrier properties	953:998	The structural, optical and barrier properties of the films	953:1011	The structural, optical and barrier properties of the films were evaluated.
32173440	2	7	theme	pectin	489:494	arg1	composition					419:429	a polymer composition	409:429	a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin	409:494	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	4	8	theme	1.995	872:876	arg1	mixture					861:867	a mixture	859:867	a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties	859:950	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli was enhanced when applying a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties.
32173440	6	9	theme	common	1107:1112	arg1	growth					1134:1139	most common food borne bacteria growth	1102:1139	most common food borne bacteria growth	1102:1139	To conclude, the enriched film showed potential coatings for controlling most common food borne bacteria growth during the food storage.
32173440	0	10	theme	surface	128:134	arg1	methodology					136:146	response surface methodology	119:146	response surface methodology	119:146	Gelatin-chitosan-pectin films incorporated with rosemary essential oil: Optimized formulation using mixture design and response surface methodology.
32173440	6	11	theme	bacteria	1125:1132	arg1	growth					1134:1139	most common food borne bacteria growth	1102:1139	most common food borne bacteria growth	1102:1139	To conclude, the enriched film showed potential coatings for controlling most common food borne bacteria growth during the food storage.
32173440	4	12	theme	Enterococcus	765:776	arg1	subtilis					732:739	Bacillus subtilis	723:739	Bacillus subtilis	723:739	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli was enhanced when applying a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties.
32173440	4	12	theme	Enterococcus	765:776	arg1	aerogenes					778:786	Enterococcus aerogenes	765:786	Enterococcus aerogenes	765:786	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli was enhanced when applying a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties.
32173440	6	13	theme	potential	1067:1075	arg1	coatings					1077:1084	potential coatings	1067:1084	potential coatings for controlling most common food borne bacteria growth during the food storage	1067:1163	To conclude, the enriched film showed potential coatings for controlling most common food borne bacteria growth during the food storage.
32173440	0	14	theme	response	119:126	arg1	methodology					136:146	response surface methodology	119:146	response surface methodology	119:146	Gelatin-chitosan-pectin films incorporated with rosemary essential oil: Optimized formulation using mixture design and response surface methodology.
32173440	6	15	theme	food	1114:1117	arg1	growth					1134:1139	most common food borne bacteria growth	1102:1139	most common food borne bacteria growth	1102:1139	To conclude, the enriched film showed potential coatings for controlling most common food borne bacteria growth during the food storage.
32173440	0	16	theme	Gelatin-chitosan-pectin	0:22	arg1	films					24:28	Gelatin-chitosan-pectin films	0:28	Gelatin-chitosan-pectin films	0:28	Gelatin-chitosan-pectin films incorporated with rosemary essential oil: Optimized formulation using mixture design and response surface methodology.
32173440	2	17	theme	%	487:487	arg1	pectin					489:494	0.5% pectin	484:494	0.5% pectin	484:494	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	6	18	theme	food	1152:1155	arg1	storage					1157:1163	the food storage	1148:1163	the food storage	1148:1163	To conclude, the enriched film showed potential coatings for controlling most common food borne bacteria growth during the food storage.
32173440	2	19	theme	glycerol	440:447	arg1	composition					419:429	a polymer composition	409:429	a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin	409:494	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	1	20	theme	rosemary	290:297	arg1	oil					309:311	rosemary essential oil	290:311	rosemary essential oil (REO)	290:317	The aim of this study was to optimize the mechanical and texture properties of edible film improving its antibacterial property after adding rosemary essential oil (REO) using a Doehlert matrix.
32173440	1	20	theme	rosemary	290:297	arg1	REO					314:316	REO	314:316	REO	314:316	The aim of this study was to optimize the mechanical and texture properties of edible film improving its antibacterial property after adding rosemary essential oil (REO) using a Doehlert matrix.
32173440	3	21	theme	break	549:553	arg1	values					585:590	break, tensile strength and texture values	549:590	break, tensile strength and texture values	549:590	This composition provided the highest elongation at break, tensile strength and texture values, which were respectively 51.60 ± 6.04%, 8.53 ± 2.36 MPa and 13.67 ± 1.43.
32173440	1	22	theme	mechanical	191:200	arg1	properties					214:223	the mechanical and texture properties	187:223	properties	214:223	The aim of this study was to optimize the mechanical and texture properties of edible film improving its antibacterial property after adding rosemary essential oil (REO) using a Doehlert matrix.
32173440	2	23	theme	%	438:438	arg1	glycerol					440:447	65.2% glycerol	434:447	65.2% glycerol	434:447	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	1	24	theme	essential	299:307	arg1	oil					309:311	rosemary essential oil	290:311	rosemary essential oil (REO)	290:317	The aim of this study was to optimize the mechanical and texture properties of edible film improving its antibacterial property after adding rosemary essential oil (REO) using a Doehlert matrix.
32173440	1	24	theme	essential	299:307	arg1	REO					314:316	REO	314:316	REO	314:316	The aim of this study was to optimize the mechanical and texture properties of edible film improving its antibacterial property after adding rosemary essential oil (REO) using a Doehlert matrix.
32173440	3	25	theme	highest	527:533	arg1	elongation					535:544	the highest elongation	523:544	the highest elongation	523:544	This composition provided the highest elongation at break, tensile strength and texture values, which were respectively 51.60 ± 6.04%, 8.53 ± 2.36 MPa and 13.67 ± 1.43.
32173440	5	26	theme	films	1007:1011	arg1	properties					989:998	The structural, optical and barrier properties	953:998	The structural, optical and barrier properties of the films	953:1011	The structural, optical and barrier properties of the films were evaluated.
32173440	2	27	theme	65.2	434:437	arg1	%					438:438	%	438:438	%	438:438	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	5	28	theme	optical	969:975	arg1	properties					989:998	The structural, optical and barrier properties	953:998	The structural, optical and barrier properties of the films	953:1011	The structural, optical and barrier properties of the films were evaluated.
32173440	1	29	theme	texture	206:212	arg1	properties					214:223	the mechanical and texture properties	187:223	properties	214:223	The aim of this study was to optimize the mechanical and texture properties of edible film improving its antibacterial property after adding rosemary essential oil (REO) using a Doehlert matrix.
32173440	0	30	theme	essential	57:65	arg1	oil					67:69	rosemary essential oil	48:69	rosemary essential oil	48:69	Gelatin-chitosan-pectin films incorporated with rosemary essential oil: Optimized formulation using mixture design and response surface methodology.
32173440	4	31	theme	rosemary	923:930	arg1	varieties					942:950	two rosemary different varieties	919:950	two rosemary different varieties	919:950	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli was enhanced when applying a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties.
32173440	3	32	theme	strength	564:571	arg1	values					585:590	break, tensile strength and texture values	549:590	break, tensile strength and texture values	549:590	This composition provided the highest elongation at break, tensile strength and texture values, which were respectively 51.60 ± 6.04%, 8.53 ± 2.36 MPa and 13.67 ± 1.43.
32173440	6	33	theme	enriched	1046:1053	arg1	film					1055:1058	the enriched film	1042:1058	the enriched film	1042:1058	To conclude, the enriched film showed potential coatings for controlling most common food borne bacteria growth during the food storage.
32173440	2	34	theme	polymer	411:417	arg1	composition					419:429	a polymer composition	409:429	a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin	409:494	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	0	35	theme	rosemary	48:55	arg1	oil					67:69	rosemary essential oil	48:69	rosemary essential oil	48:69	Gelatin-chitosan-pectin films incorporated with rosemary essential oil: Optimized formulation using mixture design and response surface methodology.
32173440	2	36	theme	gelatin	456:462	arg1	%					454:454	24.3% gelatin	450:462	24.3% gelatin	450:462	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	2	37	with	Films	344:348	arg1	properties					378:387	the highest mechanical properties	355:387	the highest mechanical properties	355:387	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	2	38	theme	0.5	484:486	arg1	%					487:487	%	487:487	%	487:487	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	2	39	theme	%	454:454	arg1	composition					419:429	a polymer composition	409:429	a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin	409:494	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	2	40	theme	chitosan	471:478	arg1	composition					419:429	a polymer composition	409:429	a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin	409:494	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	4	41	theme	REO	696:698	arg1	films					709:713	REO enriched films	696:713	REO enriched films	696:713	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli was enhanced when applying a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties.
32173440	4	42	theme	1.250 mg/g	882:891	arg1	mixture					861:867	a mixture	859:867	a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties	859:950	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli was enhanced when applying a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties.
32173440	3	43	theme	tensile	556:562	arg1	strength					564:571	tensile strength	556:571	tensile strength	556:571	This composition provided the highest elongation at break, tensile strength and texture values, which were respectively 51.60 ± 6.04%, 8.53 ± 2.36 MPa and 13.67 ± 1.43.
32173440	6	44	theme	borne	1119:1123	arg1	growth					1134:1139	most common food borne bacteria growth	1102:1139	most common food borne bacteria growth	1102:1139	To conclude, the enriched film showed potential coatings for controlling most common food borne bacteria growth during the food storage.
32173440	4	45	theme	REO	900:902	arg1	1.250 mg/g					882:891	1.250 mg/g	882:891	1.250 mg/g	882:891	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli was enhanced when applying a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties.
32173440	4	45	theme	REO	900:902	arg1	1.995					872:876	1.995	872:876	1.995	872:876	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli was enhanced when applying a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties.
32173440	5	46	theme	barrier	981:987	arg1	properties					989:998	The structural, optical and barrier properties	953:998	The structural, optical and barrier properties of the films	953:1011	The structural, optical and barrier properties of the films were evaluated.
32173440	4	47	theme	films	709:713	arg1	activity					684:691	The antibacterial activity	666:691	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli	666:830	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli was enhanced when applying a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties.
32173440	1	48	theme	edible	228:233	arg1	film					235:238	edible film	228:238	edible film improving its antibacterial property after adding rosemary essential oil (REO) using a Doehlert matrix	228:341	The aim of this study was to optimize the mechanical and texture properties of edible film improving its antibacterial property after adding rosemary essential oil (REO) using a Doehlert matrix.
32173440	0	49	dep	incorporated	30:41	arg1	formulation					82:92	Optimized formulation	72:92	Optimized formulation using mixture design and response surface methodology	72:146	Gelatin-chitosan-pectin films incorporated with rosemary essential oil: Optimized formulation using mixture design and response surface methodology.
32173440	4	50	theme	enriched	700:707	arg1	films					709:713	REO enriched films	696:713	REO enriched films	696:713	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli was enhanced when applying a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties.
32173440	1	51	theme	film	235:238	arg1	properties					214:223	the mechanical and texture properties	187:223	properties	214:223	The aim of this study was to optimize the mechanical and texture properties of edible film improving its antibacterial property after adding rosemary essential oil (REO) using a Doehlert matrix.
32173440	3	52	theme	texture	577:583	arg1	values					585:590	break, tensile strength and texture values	549:590	break, tensile strength and texture values	549:590	This composition provided the highest elongation at break, tensile strength and texture values, which were respectively 51.60 ± 6.04%, 8.53 ± 2.36 MPa and 13.67 ± 1.43.
32173440	2	53	theme	mechanical	367:376	arg1	properties					378:387	the highest mechanical properties	355:387	the highest mechanical properties	355:387	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	0	54	theme	Optimized	72:80	arg1	formulation					82:92	Optimized formulation	72:92	Optimized formulation using mixture design and response surface methodology	72:146	Gelatin-chitosan-pectin films incorporated with rosemary essential oil: Optimized formulation using mixture design and response surface methodology.
32173440	1	55	theme	Doehlert	327:334	arg1	matrix					336:341	a Doehlert matrix	325:341	a Doehlert matrix	325:341	The aim of this study was to optimize the mechanical and texture properties of edible film improving its antibacterial property after adding rosemary essential oil (REO) using a Doehlert matrix.
32173440	2	56	theme	highest	359:365	arg1	properties					378:387	the highest mechanical properties	355:387	the highest mechanical properties	355:387	Films with the highest mechanical properties were acquired using a polymer composition of 65.2% glycerol, 24.3% gelatin, 10.0% chitosan and 0.5% pectin.
32173440	4	57	theme	different	932:940	arg1	varieties					942:950	two rosemary different varieties	919:950	two rosemary different varieties	919:950	The antibacterial activity of REO enriched films against Bacillus subtilis, Staphylococcus aureus, Enterococcus aerogenes, Enterococcus faecalis and Escherichia coli was enhanced when applying a mixture of 1.995 and 1.250 mg/g of two REO extracted from two rosemary different varieties.
34203163	5	0	theme	room	1095:1098	arg1	temperature					1100:1110	room temperature	1095:1110	room temperature at 52% relative humidity	1095:1135	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	4	1	theme	thin	875:878	arg1	films					880:884	self-standing thin films	861:884	self-standing thin films	861:884	To fabricate nanocellulose-based films, CNF, TOCNF, and TOCNF with glycerol (TOCNF/G) were dispersed in water and applied on polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method.
34203163	11	2	from	sensors	1884:1890	arg1	future					1899:1904	future	1899:1904	future	1899:1904	Therefore, our study results should further propel in-depth research regarding various applications of cellulose-based sensors in the future.
34203163	3	3	theme	cellulose	506:514	arg1	nanofibers					431:440	cellulose nanofibers	421:440	cellulose nanofibers (CNF)	421:446	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	3	theme	cellulose	506:514	arg1	nanofibers					516:525	2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers	452:525	2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF)	452:533	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	3	theme	cellulose	506:514	arg1	material					640:647	a potential gas sensing material	616:647	a potential gas sensing material with highly sensitive performance	616:681	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	3	theme	cellulose	506:514	arg1	TOCNF					528:532	TOCNF	528:532	TOCNF	528:532	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	1	4	theme	biocompatibility	252:267	arg1	materials					194:202	materials	194:202	materials because of their versatility, renewability, and biocompatibility	194:267	Cellulose and its derivatives have evoked much attention in sensor technology as host-matrices for conducting materials because of their versatility, renewability, and biocompatibility.
34203163	7	5	theme	TOCNF-coated	1339:1350	arg1	sensors					1352:1358	the TOCNF-coated sensors	1335:1358	the TOCNF-coated sensors	1335:1358	The results indicate that both the CNF- and the TOCNF-coated sensors show good sensitivity toward ammonia and acetone, compared to other gases.
34203163	4	6	with	TOCNF	729:733	arg1	glycerol					751:758	glycerol	751:758	glycerol (TOCNF/G)	751:768	To fabricate nanocellulose-based films, CNF, TOCNF, and TOCNF with glycerol (TOCNF/G) were dispersed in water and applied on polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method.
34203163	4	6	with	TOCNF	729:733	arg1	TOCNF/G					761:767	TOCNF/G	761:767	TOCNF/G	761:767	To fabricate nanocellulose-based films, CNF, TOCNF, and TOCNF with glycerol (TOCNF/G) were dispersed in water and applied on polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method.
34203163	4	7	theme	self-standing	861:873	arg1	films					880:884	self-standing thin films	861:884	self-standing thin films	861:884	To fabricate nanocellulose-based films, CNF, TOCNF, and TOCNF with glycerol (TOCNF/G) were dispersed in water and applied on polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method.
34203163	6	8	with	ppm	1226:1228	arg1	response					1263:1270	less than 10 min response	1246:1270	less than 10 min response	1246:1270	The sensor prototypes exhibited high sensitivity, and the detection limit was between 1 ppm and 5 ppm, with less than 10 min response and recovery time.
34203163	6	8	with	ppm	1226:1228	arg1	time					1285:1288	recovery time	1276:1288	recovery time	1276:1288	The sensor prototypes exhibited high sensitivity, and the detection limit was between 1 ppm and 5 ppm, with less than 10 min response and recovery time.
34203163	9	9	theme	nanocellulose-based	1567:1585	arg1	sensors					1587:1593	nanocellulose-based sensors	1567:1593	nanocellulose-based sensors	1567:1593	In this study, nanocellulose-based sensors were successfully fabricated using a low-cost process and a bio-based platform.
34203163	11	10	theme	sensors	1884:1890	arg1	applications					1852:1863	various applications	1844:1863	various applications of cellulose-based sensors in the future	1844:1904	Therefore, our study results should further propel in-depth research regarding various applications of cellulose-based sensors in the future.
34203163	10	11	theme	ambient	1745:1751	arg1	conditions					1753:1762	ambient conditions	1745:1762	ambient conditions	1745:1762	They showed good sensitivity for the detection of various gases under ambient conditions.
34203163	7	12	theme	good	1365:1368	arg1	sensitivity					1370:1380	good sensitivity	1365:1380	good sensitivity toward ammonia and acetone	1365:1407	The results indicate that both the CNF- and the TOCNF-coated sensors show good sensitivity toward ammonia and acetone, compared to other gases.
34203163	4	13	with	CNF	724:726	arg1	glycerol					751:758	glycerol	751:758	glycerol (TOCNF/G)	751:768	To fabricate nanocellulose-based films, CNF, TOCNF, and TOCNF with glycerol (TOCNF/G) were dispersed in water and applied on polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method.
34203163	4	13	with	CNF	724:726	arg1	TOCNF/G					761:767	TOCNF/G	761:767	TOCNF/G	761:767	To fabricate nanocellulose-based films, CNF, TOCNF, and TOCNF with glycerol (TOCNF/G) were dispersed in water and applied on polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method.
34203163	5	14	theme	plate	962:966	arg1	surface					947:953	the surface	943:953	the surface of the plate	943:966	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	3	15	theme	rice	550:553	arg1	husks					555:559	rice husks	550:559	rice husks	550:559	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	5	16	theme	hydrogen	1069:1076	arg1	sulfide					1078:1084	hydrogen sulfide	1069:1084	hydrogen sulfide	1069:1084	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	11	17	theme	in-depth	1816:1823	arg1	research					1825:1832	in-depth research	1816:1832	in-depth research regarding various applications of cellulose-based sensors in the future	1816:1904	Therefore, our study results should further propel in-depth research regarding various applications of cellulose-based sensors in the future.
34203163	5	18	theme	coating	926:932	arg1	layer					934:938	A transparent coating layer	912:938	A transparent coating layer on the surface of the plate after drying	912:979	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	11	19	theme	cellulose-based	1868:1882	arg1	sensors					1884:1890	cellulose-based sensors	1868:1890	cellulose-based sensors in the future	1868:1904	Therefore, our study results should further propel in-depth research regarding various applications of cellulose-based sensors in the future.
34203163	5	20	theme	sulfide	1078:1084	arg1	gases					1086:1090	acetone, ammonia, methane, and hydrogen sulfide gases	1038:1090	acetone, ammonia, methane, and hydrogen sulfide gases	1038:1090	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	4	21	theme	digital	834:840	arg1	electrodes					842:851	digital electrodes	834:851	digital electrodes	834:851	To fabricate nanocellulose-based films, CNF, TOCNF, and TOCNF with glycerol (TOCNF/G) were dispersed in water and applied on polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method.
34203163	4	22	with	substrate	819:827	arg1	electrodes					842:851	digital electrodes	834:851	digital electrodes	834:851	To fabricate nanocellulose-based films, CNF, TOCNF, and TOCNF with glycerol (TOCNF/G) were dispersed in water and applied on polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method.
34203163	2	23	theme	composite	385:393	arg1	structure					395:403	a composite structure	383:403	a composite structure	383:403	However, only a few studies have dealt with the potential utilization of cellulose as a sensing material without a composite structure.
34203163	0	24	theme	Husk-Derived	5:16	arg1	Nanofibers					28:37	Rice Husk-Derived Cellulose Nanofibers	0:37	Rice Husk-Derived Cellulose Nanofibers: A Potential Sensor for Water-Soluble Gases.	0:82	Rice Husk-Derived Cellulose Nanofibers: A Potential Sensor for Water-Soluble Gases.
34203163	8	25	theme	minimum	1469:1475	arg1	time					1477:1480	minimum time	1469:1480	minimum time	1469:1480	A TOCNF/G-coated sensor exhibited minimum time in regard to response/recovery time, compared to a CNF-coated sensor.
34203163	5	26	from	layer	934:938	arg1	surface					947:953	the surface	943:953	the surface of the plate	943:966	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	10	27	theme	gases	1733:1737	arg1	detection					1712:1720	the detection	1708:1720	the detection of various gases	1708:1737	They showed good sensitivity for the detection of various gases under ambient conditions.
34203163	0	28	theme	Rice	0:3	arg1	Nanofibers					28:37	Rice Husk-Derived Cellulose Nanofibers	0:37	Rice Husk-Derived Cellulose Nanofibers: A Potential Sensor for Water-Soluble Gases.	0:82	Rice Husk-Derived Cellulose Nanofibers: A Potential Sensor for Water-Soluble Gases.
34203163	9	29	theme	bio-based	1655:1663	arg1	platform					1665:1672	a bio-based platform	1653:1672	a bio-based platform	1653:1672	In this study, nanocellulose-based sensors were successfully fabricated using a low-cost process and a bio-based platform.
34203163	9	30	theme	low-cost	1632:1639	arg1	process					1641:1647	a low-cost process	1630:1647	a low-cost process	1630:1647	In this study, nanocellulose-based sensors were successfully fabricated using a low-cost process and a bio-based platform.
34203163	7	31	theme	other	1422:1426	arg1	gases					1428:1432	other gases	1422:1432	other gases	1422:1432	The results indicate that both the CNF- and the TOCNF-coated sensors show good sensitivity toward ammonia and acetone, compared to other gases.
34203163	3	32	theme	ultrasonic-assisted	570:588	arg1	methods					590:596	ultrasonic-assisted methods	570:596	ultrasonic-assisted methods	570:596	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	33	with	material	640:647	arg1	performance					671:681	highly sensitive performance	654:681	highly sensitive performance	654:681	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	34	theme	cellulose	421:429	arg1	nanofibers					431:440	cellulose nanofibers	421:440	cellulose nanofibers (CNF)	421:446	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	34	theme	cellulose	421:429	arg1	nanofibers					516:525	2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers	452:525	2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF)	452:533	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	34	theme	cellulose	421:429	arg1	material					640:647	a potential gas sensing material	616:647	a potential gas sensing material with highly sensitive performance	616:681	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	34	theme	cellulose	421:429	arg1	CNF					443:445	CNF	443:445	CNF	443:445	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	6	35	theme	high	1170:1173	arg1	sensitivity					1175:1185	high sensitivity	1170:1185	high sensitivity	1170:1185	The sensor prototypes exhibited high sensitivity, and the detection limit was between 1 ppm and 5 ppm, with less than 10 min response and recovery time.
34203163	6	36	theme	recovery	1276:1283	arg1	time					1285:1288	recovery time	1276:1288	recovery time	1276:1288	The sensor prototypes exhibited high sensitivity, and the detection limit was between 1 ppm and 5 ppm, with less than 10 min response and recovery time.
34203163	5	37	theme	gases	1024:1028	arg1	detection					997:1005	the detection	993:1005	the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity	993:1135	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	0	38	theme	Cellulose	18:26	arg1	Nanofibers					28:37	Rice Husk-Derived Cellulose Nanofibers	0:37	Rice Husk-Derived Cellulose Nanofibers: A Potential Sensor for Water-Soluble Gases.	0:82	Rice Husk-Derived Cellulose Nanofibers: A Potential Sensor for Water-Soluble Gases.
34203163	8	39	theme	response/recovery	1495:1511	arg1	time					1513:1516	response/recovery time	1495:1516	response/recovery time	1495:1516	A TOCNF/G-coated sensor exhibited minimum time in regard to response/recovery time, compared to a CNF-coated sensor.
34203163	5	40	theme	ammonia	1047:1053	arg1	gases					1086:1090	acetone, ammonia, methane, and hydrogen sulfide gases	1038:1090	acetone, ammonia, methane, and hydrogen sulfide gases	1038:1090	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	5	41	from	temperature	1100:1110	arg1	detection					997:1005	the detection	993:1005	the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity	993:1135	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	5	42	theme	transparent	914:924	arg1	layer					934:938	A transparent coating layer	912:938	A transparent coating layer on the surface of the plate after drying	912:979	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	3	43	theme	sensitive	661:669	arg1	performance					671:681	highly sensitive performance	654:681	highly sensitive performance	654:681	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	4	44	theme	polyimide	809:817	arg1	substrate					819:827	polyimide substrate	809:827	polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method	809:909	To fabricate nanocellulose-based films, CNF, TOCNF, and TOCNF with glycerol (TOCNF/G) were dispersed in water and applied on polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method.
34203163	11	45	theme	various	1844:1850	arg1	applications					1852:1863	various applications	1844:1863	various applications of cellulose-based sensors in the future	1844:1904	Therefore, our study results should further propel in-depth research regarding various applications of cellulose-based sensors in the future.
34203163	10	46	theme	various	1725:1731	arg1	gases					1733:1737	various gases	1725:1737	various gases	1725:1737	They showed good sensitivity for the detection of various gases under ambient conditions.
34203163	5	47	used	used	984:987	arg2	layer					934:938	A transparent coating layer	912:938	A transparent coating layer on the surface of the plate after drying	912:979	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	5	47	used	used	984:987	arg2	surface					947:953	the surface	943:953	the surface of the plate	943:966	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	5	48	theme	52	1115:1116	arg1	%					1117:1117	%	1117:1117	%	1117:1117	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	6	49	dep	min	1259:1261	arg1	10					1256:1257	10	1256:1257	10	1256:1257	The sensor prototypes exhibited high sensitivity, and the detection limit was between 1 ppm and 5 ppm, with less than 10 min response and recovery time.
34203163	5	50	theme	methane	1056:1062	arg1	gases					1086:1090	acetone, ammonia, methane, and hydrogen sulfide gases	1038:1090	acetone, ammonia, methane, and hydrogen sulfide gases	1038:1090	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	6	51	theme	detection	1196:1204	arg1	limit					1206:1210	the detection limit	1192:1210	the detection limit	1192:1210	The sensor prototypes exhibited high sensitivity, and the detection limit was between 1 ppm and 5 ppm, with less than 10 min response and recovery time.
34203163	1	52	theme	versatility	221:231	arg1	materials					194:202	materials	194:202	materials because of their versatility, renewability, and biocompatibility	194:267	Cellulose and its derivatives have evoked much attention in sensor technology as host-matrices for conducting materials because of their versatility, renewability, and biocompatibility.
34203163	5	53	theme	%	1117:1117	arg1	humidity					1128:1135	52% relative humidity	1115:1135	52% relative humidity	1115:1135	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	4	54	theme	drop-casting	891:902	arg1	method					904:909	a drop-casting method	889:909	a drop-casting method	889:909	To fabricate nanocellulose-based films, CNF, TOCNF, and TOCNF with glycerol (TOCNF/G) were dispersed in water and applied on polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method.
34203163	5	55	theme	water-soluble	1010:1022	arg1	gases					1086:1090	acetone, ammonia, methane, and hydrogen sulfide gases	1038:1090	acetone, ammonia, methane, and hydrogen sulfide gases	1038:1090	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	5	55	theme	water-soluble	1010:1022	arg1	gases					1024:1028	water-soluble gases	1010:1028	water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases	1010:1090	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	6	56	dep	response	1263:1270	arg1	min					1259:1261	min	1259:1261	min	1259:1261	The sensor prototypes exhibited high sensitivity, and the detection limit was between 1 ppm and 5 ppm, with less than 10 min response and recovery time.
34203163	2	57	theme	cellulose	343:351	arg1	utilization					328:338	the potential utilization	314:338	the potential utilization of cellulose as a sensing material without a composite structure	314:403	However, only a few studies have dealt with the potential utilization of cellulose as a sensing material without a composite structure.
34203163	0	58	theme	Potential	42:50	arg1	Sensor					52:57	A Potential Sensor	40:57	Rice Husk-Derived Cellulose Nanofibers: A Potential Sensor for Water-Soluble Gases.	0:82	Rice Husk-Derived Cellulose Nanofibers: A Potential Sensor for Water-Soluble Gases.
34203163	5	59	theme	relative	1119:1126	arg1	humidity					1128:1135	52% relative humidity	1115:1135	52% relative humidity	1115:1135	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	1	60	theme	sensor	144:149	arg1	technology					151:160	sensor technology	144:160	sensor technology as host-matrices for conducting materials because of their versatility, renewability, and biocompatibility	144:267	Cellulose and its derivatives have evoked much attention in sensor technology as host-matrices for conducting materials because of their versatility, renewability, and biocompatibility.
34203163	11	61	from	future	1899:1904	arg1	applications					1852:1863	various applications	1844:1863	various applications of cellulose-based sensors in the future	1844:1904	Therefore, our study results should further propel in-depth research regarding various applications of cellulose-based sensors in the future.
34203163	3	62	theme	-oxidized	496:504	arg1	nanofibers					431:440	cellulose nanofibers	421:440	cellulose nanofibers (CNF)	421:446	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	62	theme	-oxidized	496:504	arg1	nanofibers					516:525	2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers	452:525	2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF)	452:533	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	62	theme	-oxidized	496:504	arg1	material					640:647	a potential gas sensing material	616:647	a potential gas sensing material with highly sensitive performance	616:681	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	62	theme	-oxidized	496:504	arg1	TOCNF					528:532	TOCNF	528:532	TOCNF	528:532	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	4	63	with	TOCNF	740:744	arg1	glycerol					751:758	glycerol	751:758	glycerol (TOCNF/G)	751:768	To fabricate nanocellulose-based films, CNF, TOCNF, and TOCNF with glycerol (TOCNF/G) were dispersed in water and applied on polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method.
34203163	4	63	with	TOCNF	740:744	arg1	TOCNF/G					761:767	TOCNF/G	761:767	TOCNF/G	761:767	To fabricate nanocellulose-based films, CNF, TOCNF, and TOCNF with glycerol (TOCNF/G) were dispersed in water and applied on polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method.
34203163	5	64	from	humidity	1128:1135	arg1	temperature					1100:1110	room temperature	1095:1110	room temperature at 52% relative humidity	1095:1135	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	3	65	theme	gas	628:630	arg1	nanofibers					431:440	cellulose nanofibers	421:440	cellulose nanofibers (CNF)	421:446	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	65	theme	gas	628:630	arg1	nanofibers					516:525	2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers	452:525	2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF)	452:533	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	65	theme	gas	628:630	arg1	material					640:647	a potential gas sensing material	616:647	a potential gas sensing material with highly sensitive performance	616:681	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	0	66	dep	Nanofibers	28:37	arg1	Sensor					52:57	A Potential Sensor	40:57	Rice Husk-Derived Cellulose Nanofibers: A Potential Sensor for Water-Soluble Gases.	0:82	Rice Husk-Derived Cellulose Nanofibers: A Potential Sensor for Water-Soluble Gases.
34203163	4	67	theme	nanocellulose-based	697:715	arg1	films					717:721	nanocellulose-based films	697:721	nanocellulose-based films	697:721	To fabricate nanocellulose-based films, CNF, TOCNF, and TOCNF with glycerol (TOCNF/G) were dispersed in water and applied on polyimide substrate with digital electrodes to form self-standing thin films by a drop-casting method.
34203163	1	68	theme	much	126:129	arg1	attention					131:139	much attention	126:139	much attention	126:139	Cellulose and its derivatives have evoked much attention in sensor technology as host-matrices for conducting materials because of their versatility, renewability, and biocompatibility.
34203163	8	69	theme	CNF-coated	1533:1542	arg1	sensor					1544:1549	a CNF-coated sensor	1531:1549	a CNF-coated sensor	1531:1549	A TOCNF/G-coated sensor exhibited minimum time in regard to response/recovery time, compared to a CNF-coated sensor.
34203163	10	70	theme	good	1687:1690	arg1	sensitivity					1692:1702	good sensitivity	1687:1702	good sensitivity for the detection of various gases	1687:1737	They showed good sensitivity for the detection of various gases under ambient conditions.
34203163	5	71	theme	acetone	1038:1044	arg1	gases					1086:1090	acetone, ammonia, methane, and hydrogen sulfide gases	1038:1090	acetone, ammonia, methane, and hydrogen sulfide gases	1038:1090	A transparent coating layer on the surface of the plate after drying is used for the detection of water-soluble gases such as acetone, ammonia, methane, and hydrogen sulfide gases at room temperature at 52% relative humidity.
34203163	3	72	theme	sensing	632:638	arg1	nanofibers					431:440	cellulose nanofibers	421:440	cellulose nanofibers (CNF)	421:446	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	72	theme	sensing	632:638	arg1	nanofibers					516:525	2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers	452:525	2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF)	452:533	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	72	theme	sensing	632:638	arg1	material					640:647	a potential gas sensing material	616:647	a potential gas sensing material with highly sensitive performance	616:681	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	11	73	from	applications	1852:1863	arg1	future					1899:1904	future	1899:1904	future	1899:1904	Therefore, our study results should further propel in-depth research regarding various applications of cellulose-based sensors in the future.
34203163	2	74	theme	potential	318:326	arg1	utilization					328:338	the potential utilization	314:338	the potential utilization of cellulose as a sensing material without a composite structure	314:403	However, only a few studies have dealt with the potential utilization of cellulose as a sensing material without a composite structure.
34203163	1	75	theme	renewability	234:245	arg1	materials					194:202	materials	194:202	materials because of their versatility, renewability, and biocompatibility	194:267	Cellulose and its derivatives have evoked much attention in sensor technology as host-matrices for conducting materials because of their versatility, renewability, and biocompatibility.
34203163	0	76	theme	Water-Soluble	63:75	arg1	Gases					77:81	Water-Soluble Gases	63:81	Water-Soluble Gases	63:81	Rice Husk-Derived Cellulose Nanofibers: A Potential Sensor for Water-Soluble Gases.
34203163	6	77	theme	sensor	1142:1147	arg1	prototypes					1149:1158	The sensor prototypes	1138:1158	The sensor prototypes	1138:1158	The sensor prototypes exhibited high sensitivity, and the detection limit was between 1 ppm and 5 ppm, with less than 10 min response and recovery time.
34203163	6	78	with	ppm	1236:1238	arg1	response					1263:1270	less than 10 min response	1246:1270	less than 10 min response	1246:1270	The sensor prototypes exhibited high sensitivity, and the detection limit was between 1 ppm and 5 ppm, with less than 10 min response and recovery time.
34203163	6	78	with	ppm	1236:1238	arg1	time					1285:1288	recovery time	1276:1288	recovery time	1276:1288	The sensor prototypes exhibited high sensitivity, and the detection limit was between 1 ppm and 5 ppm, with less than 10 min response and recovery time.
34203163	3	79	theme	potential	618:626	arg1	nanofibers					431:440	cellulose nanofibers	421:440	cellulose nanofibers (CNF)	421:446	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	79	theme	potential	618:626	arg1	nanofibers					516:525	2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers	452:525	2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF)	452:533	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	3	79	theme	potential	618:626	arg1	material					640:647	a potential gas sensing material	616:647	a potential gas sensing material with highly sensitive performance	616:681	In this study, cellulose nanofibers (CNF) and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) extracted from rice husks by using ultrasonic-assisted methods are introduced as a potential gas sensing material with highly sensitive performance.
34203163	2	80	theme	sensing	358:364	arg1	material					366:373	a sensing material	356:373	a sensing material without a composite structure	356:403	However, only a few studies have dealt with the potential utilization of cellulose as a sensing material without a composite structure.
34203163	8	81	theme	TOCNF/G-coated	1437:1450	arg1	sensor					1452:1457	A TOCNF/G-coated sensor	1435:1457	A TOCNF/G-coated sensor	1435:1457	A TOCNF/G-coated sensor exhibited minimum time in regard to response/recovery time, compared to a CNF-coated sensor.
34203163	11	82	theme	study	1780:1784	arg1	results					1786:1792	our study results	1776:1792	our study results	1776:1792	Therefore, our study results should further propel in-depth research regarding various applications of cellulose-based sensors in the future.
32683236	7	0	theme	2D5	1081:1083	arg1	rate					1073:1076	the cumulative release rate	1050:1076	the cumulative release rate of 2D5	1050:1083	As the concentration of nanobodies increased, the cumulative release rate of 2D5 decreased, and the release rate of KPU increased.
32683236	6	1	theme	model	973:977	arg1	nanobodies					979:988	two model nanobodies	969:988	two model nanobodies: 2D5 and KPU	969:1001	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	6	1	theme	model	973:977	arg1	KPU					999:1001	KPU	999:1001	KPU	999:1001	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	6	1	theme	model	973:977	arg1	2D5					991:993	2D5	991:993	2D5	991:993	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	6	2	theme	10 mg mL-1	893:902	arg1	chitosan					904:911	10 mg mL-1 chitosan	893:911	10 mg mL-1 chitosan	893:911	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	6	3	theme	10 mg mL-1	798:807	arg1	chitosan					809:816	10 mg mL-1 chitosan	798:816	10 mg mL-1 chitosan	798:816	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	7	4	theme	release	1104:1110	arg1	rate					1112:1115	the release rate	1100:1115	the release rate of KPU	1100:1122	As the concentration of nanobodies increased, the cumulative release rate of 2D5 decreased, and the release rate of KPU increased.
32683236	3	5	theme	tilapia	365:371	arg1	collagen					378:385	tilapia skin collagen	365:385	tilapia skin collagen	365:385	Here, we developed hydrogels prepared from tilapia skin collagen and chitosan (HCC).
32683236	4	6	theme	preparation	475:485	arg1	time					467:470	the time	463:470	the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively	463:641	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	9	7	theme	KPU	1304:1306	arg1	similar					1313:1319	similar	1313:1319	similar	1313:1319	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	9	7	theme	KPU	1304:1306	arg1	rates					1295:1299	the cumulative release rates	1272:1299	the cumulative release rates of KPU	1272:1306	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	3	8	theme	skin	373:376	arg1	collagen					378:385	tilapia skin collagen	365:385	tilapia skin collagen	365:385	Here, we developed hydrogels prepared from tilapia skin collagen and chitosan (HCC).
32683236	4	9	from	time	467:470	arg1	pH					457:458	the pH	453:458	the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively	453:641	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	9	10	dep	pH	1324:1325	arg1	6.8					1341:1343	6.8	1341:1343	6.8	1341:1343	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	9	10	dep	pH	1324:1325	arg1	7.4					1359:1361	7.4	1359:1361	7.4	1359:1361	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	9	10	dep	pH	1324:1325	arg1	5.5					1327:1329	5.5	1327:1329	5.5	1327:1329	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	9	10	dep	pH	1324:1325	arg1	%					1351:1351	46.5 %	1346:1351	46.5 %	1346:1351	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	9	10	dep	pH	1324:1325	arg1	%					1369:1369	44.9 %	1364:1369	44.9 %	1364:1369	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	9	10	dep	pH	1324:1325	arg1	%					1337:1337	45.1 %	1332:1337	45.1 %	1332:1337	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	6	11	theme	skin	875:878	arg1	collagen					880:887	5 mg mL-1 tilapia skin collagen	857:887	5 mg mL-1 tilapia skin collagen	857:887	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	7	12	theme	cumulative	1054:1063	arg1	rate					1073:1076	the cumulative release rate	1050:1076	the cumulative release rate of 2D5	1050:1083	As the concentration of nanobodies increased, the cumulative release rate of 2D5 decreased, and the release rate of KPU increased.
32683236	6	13	theme	skin	780:783	arg1	collagen					785:792	10 mg mL-1 tilapia skin collagen	761:792	10 mg mL-1 tilapia skin collagen	761:792	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	1	14	theme	drug	166:169	arg1	delivery					171:178	drug delivery	166:178	drug delivery	166:178	Recently, injectable hydrogels have shown great potential in cell therapy and drug delivery.
32683236	7	15	theme	release	1065:1071	arg1	rate					1073:1076	the cumulative release rate	1050:1076	the cumulative release rate of 2D5	1050:1083	As the concentration of nanobodies increased, the cumulative release rate of 2D5 decreased, and the release rate of KPU increased.
32683236	6	16	theme	tilapia	772:778	arg1	collagen					785:792	10 mg mL-1 tilapia skin collagen	761:792	10 mg mL-1 tilapia skin collagen	761:792	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	4	17	from	%	503:503	arg1	36 h.					516:520	36 h.	516:520	36 h.	516:520	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	10	18	theme	release	1418:1424	arg1	nanobodies					1426:1435	the release nanobodies	1414:1435	the release nanobodies	1414:1435	HCC is biodegradable, and can facilitate the release nanobodies; thus, HCC could be developed into an intelligent responsive tumor treatment matrix for use in cancer therapy.
32683236	8	19	theme	release	1161:1167	arg1	rate					1169:1172	the cumulative release rate	1146:1172	the cumulative release rate of 2D5	1146:1179	Meanwhile, the cumulative release rate of 2D5 was the highest (68.3 %) at pH 5.5, followed by pH 6.8 (56.4 %) and 7.4 (28.4 %).
32683236	8	19	theme	release	1161:1167	arg1	Meanwhile					1135:1143	Meanwhile	1135:1143	Meanwhile	1135:1143	Meanwhile, the cumulative release rate of 2D5 was the highest (68.3 %) at pH 5.5, followed by pH 6.8 (56.4 %) and 7.4 (28.4 %).
32683236	6	20	theme	10 mg mL-1	761:770	arg1	collagen					785:792	10 mg mL-1 tilapia skin collagen	761:792	10 mg mL-1 tilapia skin collagen	761:792	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	10	21	from	use	1525:1527	arg1	therapy					1539:1545	cancer therapy	1532:1545	cancer therapy	1532:1545	HCC is biodegradable, and can facilitate the release nanobodies; thus, HCC could be developed into an intelligent responsive tumor treatment matrix for use in cancer therapy.
32683236	4	22	from	values	575:580	arg1	%					621:621	%	621:621	%	621:621	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	4	22	from	values	575:580	arg1	ratios					555:560	the residual mass ratios	537:560	the residual mass ratios of HCC at pH values of 6 and 5	537:591	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	6	23	theme	HCC10	952:956	arg1	ability					941:947	that ability	936:947	that ability of HCC10	936:956	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	6	24	theme	tilapia	867:873	arg1	collagen					880:887	5 mg mL-1 tilapia skin collagen	857:887	5 mg mL-1 tilapia skin collagen	857:887	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	4	25	theme	6	585:585	arg1	values					575:580	pH values	572:580	pH values of 6 and 5	572:591	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	0	26	theme	collagen	23:30	arg1	Development					0:10	Development	0:10	Development of tilapia collagen and chitosan composite	0:53	Development of tilapia collagen and chitosan composite hydrogels for nanobody delivery.
32683236	6	27	theme	5 mg mL-1	857:865	arg1	collagen					880:887	5 mg mL-1 tilapia skin collagen	857:887	5 mg mL-1 tilapia skin collagen	857:887	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	8	28	theme	cumulative	1150:1159	arg1	rate					1169:1172	the cumulative release rate	1146:1172	the cumulative release rate of 2D5	1146:1179	Meanwhile, the cumulative release rate of 2D5 was the highest (68.3 %) at pH 5.5, followed by pH 6.8 (56.4 %) and 7.4 (28.4 %).
32683236	8	28	theme	cumulative	1150:1159	arg1	Meanwhile					1135:1143	Meanwhile	1135:1143	Meanwhile	1135:1143	Meanwhile, the cumulative release rate of 2D5 was the highest (68.3 %) at pH 5.5, followed by pH 6.8 (56.4 %) and 7.4 (28.4 %).
32683236	1	29	theme	injectable	98:107	arg1	hydrogels					109:117	injectable hydrogels	98:117	injectable hydrogels	98:117	Recently, injectable hydrogels have shown great potential in cell therapy and drug delivery.
32683236	4	30	theme	HCC	565:567	arg1	%					621:621	%	621:621	%	621:621	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	4	30	theme	HCC	565:567	arg1	ratios					555:560	the residual mass ratios	537:560	the residual mass ratios of HCC at pH values of 6 and 5	537:591	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	0	31	theme	tilapia	15:21	arg1	collagen					23:30	tilapia collagen	15:30	tilapia collagen	15:30	Development of tilapia collagen and chitosan composite hydrogels for nanobody delivery.
32683236	10	32	theme	cancer	1532:1537	arg1	therapy					1539:1545	cancer therapy	1532:1545	cancer therapy	1532:1545	HCC is biodegradable, and can facilitate the release nanobodies; thus, HCC could be developed into an intelligent responsive tumor treatment matrix for use in cancer therapy.
32683236	2	33	theme	invasive	301:308	arg1	strategies					310:319	minimally invasive strategies	291:319	minimally invasive strategies	291:319	They can easily fill in any irregular-shaped defects and remain in desired positions after implantation using minimally invasive strategies.
32683236	0	34	theme	chitosan	36:43	arg1	Development					0:10	Development	0:10	Development of tilapia collagen and chitosan composite	0:53	Development of tilapia collagen and chitosan composite hydrogels for nanobody delivery.
32683236	8	35	theme	2D5	1177:1179	arg1	rate					1169:1172	the cumulative release rate	1146:1172	the cumulative release rate of 2D5	1146:1179	Meanwhile, the cumulative release rate of 2D5 was the highest (68.3 %) at pH 5.5, followed by pH 6.8 (56.4 %) and 7.4 (28.4 %).
32683236	8	35	theme	2D5	1177:1179	arg1	Meanwhile					1135:1143	Meanwhile	1135:1143	Meanwhile	1135:1143	Meanwhile, the cumulative release rate of 2D5 was the highest (68.3 %) at pH 5.5, followed by pH 6.8 (56.4 %) and 7.4 (28.4 %).
32683236	4	36	theme	HCC	433:435	arg1	rate					425:428	The residual mass rate	407:428	The residual mass rate of HCC	407:435	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	10	37	theme	intelligent	1475:1485	arg1	matrix					1514:1519	an intelligent responsive tumor treatment matrix	1472:1519	an intelligent responsive tumor treatment matrix for use in cancer therapy	1472:1545	HCC is biodegradable, and can facilitate the release nanobodies; thus, HCC could be developed into an intelligent responsive tumor treatment matrix for use in cancer therapy.
32683236	4	38	theme	pH	572:573	arg1	values					575:580	pH values	572:580	pH values of 6 and 5	572:591	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	5	39	theme	HCC	674:676	arg1	stability					661:669	the stability	657:669	the stability of HCC	657:676	In addition, the stability of HCC was also affected by the concentration of these two components.
32683236	4	40	from	pH	508:509	arg1	%					503:503	29.1 %	498:503	29.1 %	498:503	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	5	41	theme	components	730:739	arg1	concentration					703:715	the concentration	699:715	the concentration of these two components	699:739	In addition, the stability of HCC was also affected by the concentration of these two components.
32683236	10	42	theme	treatment	1504:1512	arg1	matrix					1514:1519	an intelligent responsive tumor treatment matrix	1472:1519	an intelligent responsive tumor treatment matrix for use in cancer therapy	1472:1545	HCC is biodegradable, and can facilitate the release nanobodies; thus, HCC could be developed into an intelligent responsive tumor treatment matrix for use in cancer therapy.
32683236	4	43	dep	36 h.	516:520	arg1	%					621:621	%	621:621	%	621:621	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	4	43	dep	36 h.	516:520	arg1	ratios					555:560	the residual mass ratios	537:560	the residual mass ratios of HCC at pH values of 6 and 5	537:591	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	4	43	dep	36 h.	516:520	arg1	0					627:627	0	627:627	0	627:627	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	2	44	theme	irregular-shaped	209:224	arg1	defects					226:232	any irregular-shaped defects	205:232	any irregular-shaped defects	205:232	They can easily fill in any irregular-shaped defects and remain in desired positions after implantation using minimally invasive strategies.
32683236	4	45	theme	mass	420:423	arg1	rate					425:428	The residual mass rate	407:428	The residual mass rate of HCC	407:435	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	6	46	dep	nanobodies	979:988	arg1	nanobodies					979:988	two model nanobodies	969:988	two model nanobodies: 2D5 and KPU	969:1001	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	6	46	dep	nanobodies	979:988	arg1	KPU					999:1001	KPU	999:1001	KPU	999:1001	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	6	46	dep	nanobodies	979:988	arg1	2D5					991:993	2D5	991:993	2D5	991:993	HCC10 catalyzed by 10 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan was more stable than HCC5 catalyzed by 5 mg mL-1 tilapia skin collagen and 10 mg mL-1 chitosan; therefore, we studied that ability of HCC10 to deliver two model nanobodies: 2D5 and KPU.
32683236	7	47	theme	nanobodies	1028:1037	arg1	concentration					1011:1023	the concentration	1007:1023	the concentration of nanobodies	1007:1037	As the concentration of nanobodies increased, the cumulative release rate of 2D5 decreased, and the release rate of KPU increased.
32683236	4	48	theme	residual	411:418	arg1	rate					425:428	The residual mass rate	407:428	The residual mass rate of HCC	407:435	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	0	49	dep	collagen	23:30	arg1	composite					45:53	composite	45:53	composite	45:53	Development of tilapia collagen and chitosan composite hydrogels for nanobody delivery.
32683236	9	50	theme	release	1287:1293	arg1	similar					1313:1319	similar	1313:1319	similar	1313:1319	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	9	50	theme	release	1287:1293	arg1	rates					1295:1299	the cumulative release rates	1272:1299	the cumulative release rates of KPU	1272:1306	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	1	51	theme	great	130:134	arg1	potential					136:144	great potential	130:144	great potential	130:144	Recently, injectable hydrogels have shown great potential in cell therapy and drug delivery.
32683236	4	52	dep	%	621:621	arg1	8.4					617:619	8.4	617:619	8.4	617:619	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	4	53	theme	residual	541:548	arg1	%					621:621	%	621:621	%	621:621	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	4	53	theme	residual	541:548	arg1	ratios					555:560	the residual mass ratios	537:560	the residual mass ratios of HCC at pH values of 6 and 5	537:591	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	2	54	theme	desired	248:254	arg1	positions					256:264	desired positions	248:264	desired positions after implantation using minimally invasive strategies	248:319	They can easily fill in any irregular-shaped defects and remain in desired positions after implantation using minimally invasive strategies.
32683236	1	55	theme	cell	149:152	arg1	therapy					154:160	cell therapy	149:160	cell therapy	149:160	Recently, injectable hydrogels have shown great potential in cell therapy and drug delivery.
32683236	9	56	from	pH	1324:1325	arg1	similar					1313:1319	similar	1313:1319	similar	1313:1319	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	9	56	from	pH	1324:1325	arg1	rates					1295:1299	the cumulative release rates	1272:1299	the cumulative release rates of KPU	1272:1306	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	7	57	theme	KPU	1120:1122	arg1	rate					1112:1115	the release rate	1100:1115	the release rate of KPU	1100:1122	As the concentration of nanobodies increased, the cumulative release rate of 2D5 decreased, and the release rate of KPU increased.
32683236	0	58	theme	nanobody	69:76	arg1	delivery					78:85	nanobody delivery	69:85	nanobody delivery	69:85	Development of tilapia collagen and chitosan composite hydrogels for nanobody delivery.
32683236	10	59	theme	tumor	1498:1502	arg1	matrix					1514:1519	an intelligent responsive tumor treatment matrix	1472:1519	an intelligent responsive tumor treatment matrix for use in cancer therapy	1472:1545	HCC is biodegradable, and can facilitate the release nanobodies; thus, HCC could be developed into an intelligent responsive tumor treatment matrix for use in cancer therapy.
32683236	9	60	theme	cumulative	1276:1285	arg1	similar					1313:1319	similar	1313:1319	similar	1313:1319	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	9	60	theme	cumulative	1276:1285	arg1	rates					1295:1299	the cumulative release rates	1272:1299	the cumulative release rates of KPU	1272:1306	However, the cumulative release rates of KPU were similar at pH 5.5 (45.1 %), 6.8 (46.5 %), and 7.4 (44.9 %).
32683236	10	61	theme	responsive	1487:1496	arg1	matrix					1514:1519	an intelligent responsive tumor treatment matrix	1472:1519	an intelligent responsive tumor treatment matrix for use in cancer therapy	1472:1545	HCC is biodegradable, and can facilitate the release nanobodies; thus, HCC could be developed into an intelligent responsive tumor treatment matrix for use in cancer therapy.
32683236	4	62	theme	5	591:591	arg1	values					575:580	pH values	572:580	pH values of 6 and 5	572:591	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	4	63	theme	mass	550:553	arg1	%					621:621	%	621:621	%	621:621	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
32683236	4	63	theme	mass	550:553	arg1	ratios					555:560	the residual mass ratios	537:560	the residual mass ratios of HCC at pH values of 6 and 5	537:591	The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively.
34464865	4	0	theme	high	707:710	arg1	efficiency					720:729	high removal efficiency	707:729	high removal efficiency (95.58%)	707:738	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	4	0	theme	high	707:710	arg1	%					737:737	95.58%	732:737	95.58%	732:737	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	1	1	theme	antibiotic	265:274	arg1	resistance					276:285	antibiotic resistance	265:285	antibiotic resistance	265:285	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	2	2	theme	shell	404:408	arg1	waste					410:414	shell waste	404:414	shell waste	404:414	In this study, a low-cost chitin-biocalcium (CC) composite was developed by a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal.
34464865	7	3	theme	macroscopic	1116:1126	arg1	aspect					1128:1133	the macroscopic aspect	1112:1133	the macroscopic aspect	1112:1133	From the macroscopic aspect, flocs were produced with the increase of CIP concentration during the reaction, adsorption combined with flocculation were related to the CIP removal.
34464865	1	4	theme	resistance	276:285	arg1	problems					224:231	the dual problems	215:231	the dual problems of bioaccumulation toxicity and antibiotic resistance	215:285	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	6	5	theme	mass	1086:1089	arg1	step					1101:1104	mass transport step	1086:1104	mass transport step	1086:1104	The kinetic experimental data was fitted well by pseudo-second-order and intraparticle diffusion model at different concentrations, revealing the removal was controlled by chemisorption and mass transport step.
34464865	6	6	from	concentrations	1012:1025	arg1	pseudo-second-order					945:963	pseudo-second-order	945:963	pseudo-second-order	945:963	The kinetic experimental data was fitted well by pseudo-second-order and intraparticle diffusion model at different concentrations, revealing the removal was controlled by chemisorption and mass transport step.
34464865	6	6	from	concentrations	1012:1025	arg1	model					993:997	intraparticle diffusion model	969:997	intraparticle diffusion model	969:997	The kinetic experimental data was fitted well by pseudo-second-order and intraparticle diffusion model at different concentrations, revealing the removal was controlled by chemisorption and mass transport step.
34464865	8	7	theme	removal	1329:1335	arg1	performance					1337:1347	the superior removal performance	1316:1347	the superior removal performance	1316:1347	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	0	8	theme	adsorption	88:97	arg1	Synergism					75:83	Synergism	75:83	Chitin-biocalcium as a novel superior composite for ciprofloxacin removal: Synergism of adsorption and flocculation.	0:115	Chitin-biocalcium as a novel superior composite for ciprofloxacin removal: Synergism of adsorption and flocculation.
34464865	8	9	theme	superior	1320:1327	arg1	performance					1337:1347	the superior removal performance	1316:1347	the superior removal performance	1316:1347	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	4	10	theme	pH	749:750	arg1	adaptability					752:763	wide pH adaptability	744:763	wide pH adaptability (under pH range 4.0-10.0)	744:789	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	4	11	theme	removal	600:606	arg1	capacity					608:615	superior CIP removal capacity	587:615	superior CIP removal capacity of 2432 mg/g	587:628	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	5	12	from	groups	807:812	arg1	content					833:839	chitin and high content	817:839	chitin and high content of biocalcium (Ca2+) endowed CC abundant active sites	817:893	The functional groups in chitin and high content of biocalcium (Ca2+) endowed CC abundant active sites.
34464865	5	13	theme	chitin	817:822	arg1	content					833:839	chitin and high content	817:839	chitin and high content of biocalcium (Ca2+) endowed CC abundant active sites	817:893	The functional groups in chitin and high content of biocalcium (Ca2+) endowed CC abundant active sites.
34464865	3	14	theme	surface	478:484	arg1	RSM					499:501	RSM	499:501	RSM	499:501	Response surface methodology (RSM) was utilized to optimize synthesis methodology.
34464865	3	14	theme	surface	478:484	arg1	methodology					486:496	Response surface methodology	469:496	Response surface methodology (RSM)	469:502	Response surface methodology (RSM) was utilized to optimize synthesis methodology.
34464865	3	15	theme	synthesis	529:537	arg1	methodology					539:549	synthesis methodology	529:549	synthesis methodology	529:549	Response surface methodology (RSM) was utilized to optimize synthesis methodology.
34464865	4	16	theme	rapid	680:684	arg1	kinetics					697:704	rapid adsorption kinetics	680:704	rapid adsorption kinetics	680:704	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	1	17	theme	attracting	178:187	arg1	concern					200:206	attracting increasing concern	178:206	attracting increasing concern	178:206	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	1	17	theme	attracting	178:187	arg1	antibiotics					140:150	The ubiquitous present antibiotics	117:150	The ubiquitous present antibiotics in aquatic environment	117:173	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	0	18	theme	flocculation	103:114	arg1	Synergism					75:83	Synergism	75:83	Chitin-biocalcium as a novel superior composite for ciprofloxacin removal: Synergism of adsorption and flocculation.	0:115	Chitin-biocalcium as a novel superior composite for ciprofloxacin removal: Synergism of adsorption and flocculation.
34464865	4	19	theme	CIP	596:598	arg1	capacity					608:615	superior CIP removal capacity	587:615	superior CIP removal capacity of 2432 mg/g	587:628	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	6	20	theme	different	1002:1010	arg1	concentrations					1012:1025	different concentrations	1002:1025	different concentrations	1002:1025	The kinetic experimental data was fitted well by pseudo-second-order and intraparticle diffusion model at different concentrations, revealing the removal was controlled by chemisorption and mass transport step.
34464865	1	21	theme	increasing	189:198	arg1	concern					200:206	attracting increasing concern	178:206	attracting increasing concern	178:206	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	1	21	theme	increasing	189:198	arg1	antibiotics					140:150	The ubiquitous present antibiotics	117:150	The ubiquitous present antibiotics in aquatic environment	117:173	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	1	22	from	antibiotics	140:150	arg1	environment					163:173	aquatic environment	155:173	aquatic environment	155:173	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	2	23	theme	CC	333:334	arg1	composite					337:345	a low-cost chitin-biocalcium (CC) composite	303:345	a low-cost chitin-biocalcium (CC) composite	303:345	In this study, a low-cost chitin-biocalcium (CC) composite was developed by a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal.
34464865	2	24	theme	process	391:397	arg1	removal					460:466	a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal	364:466	a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal	364:466	In this study, a low-cost chitin-biocalcium (CC) composite was developed by a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal.
34464865	4	25	theme	CC	566:567	arg1	products					569:576	The optimized CC products	552:576	The optimized CC products	552:576	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	8	26	theme	CIP	1483:1485	arg1	groups					1462:1467	functional groups	1451:1467	functional groups of chitin and CIP	1451:1485	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	8	26	theme	CIP	1483:1485	arg1	CIP					1483:1485	CIP	1483:1485	CIP	1483:1485	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	8	26	theme	CIP	1483:1485	arg1	chitin					1472:1477	chitin	1472:1477	chitin	1472:1477	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	6	27	theme	diffusion	983:991	arg1	model					993:997	intraparticle diffusion model	969:997	intraparticle diffusion model	969:997	The kinetic experimental data was fitted well by pseudo-second-order and intraparticle diffusion model at different concentrations, revealing the removal was controlled by chemisorption and mass transport step.
34464865	2	28	theme	activation	380:389	arg1	process					391:397	a facile alkali activation process	364:397	a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal	364:466	In this study, a low-cost chitin-biocalcium (CC) composite was developed by a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal.
34464865	0	29	theme	novel	23:27	arg1	composite					38:46	a novel superior composite	21:46	a novel superior composite for ciprofloxacin removal	21:72	Chitin-biocalcium as a novel superior composite for ciprofloxacin removal: Synergism of adsorption and flocculation.
34464865	4	30	theme	optimized	556:564	arg1	products					569:576	The optimized CC products	552:576	The optimized CC products	552:576	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	2	31	theme	chitin-biocalcium	314:330	arg1	composite					337:345	a low-cost chitin-biocalcium (CC) composite	303:345	a low-cost chitin-biocalcium (CC) composite	303:345	In this study, a low-cost chitin-biocalcium (CC) composite was developed by a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal.
34464865	8	32	theme	microcosmic	1296:1306	arg1	aspect					1308:1313	the microcosmic aspect	1292:1313	the microcosmic aspect	1292:1313	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	3	33	theme	Response	469:476	arg1	RSM					499:501	RSM	499:501	RSM	499:501	Response surface methodology (RSM) was utilized to optimize synthesis methodology.
34464865	3	33	theme	Response	469:476	arg1	methodology					486:496	Response surface methodology	469:496	Response surface methodology (RSM)	469:502	Response surface methodology (RSM) was utilized to optimize synthesis methodology.
34464865	2	34	theme	ciprofloxacin	440:452	arg1	removal					460:466	a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal	364:466	a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal	364:466	In this study, a low-cost chitin-biocalcium (CC) composite was developed by a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal.
34464865	8	35	theme	functional	1451:1460	arg1	groups					1462:1467	functional groups	1451:1467	functional groups of chitin and CIP	1451:1485	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	8	35	theme	functional	1451:1460	arg1	CIP					1483:1485	CIP	1483:1485	CIP	1483:1485	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	8	35	theme	functional	1451:1460	arg1	chitin					1472:1477	chitin	1472:1477	chitin	1472:1477	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	2	36	theme	low-cost	305:312	arg1	composite					337:345	a low-cost chitin-biocalcium (CC) composite	303:345	a low-cost chitin-biocalcium (CC) composite	303:345	In this study, a low-cost chitin-biocalcium (CC) composite was developed by a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal.
34464865	2	37	theme	typical	420:426	arg1	antibiotics					428:438	typical antibiotics	420:438	typical antibiotics	420:438	In this study, a low-cost chitin-biocalcium (CC) composite was developed by a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal.
34464865	7	38	theme	concentration	1181:1193	arg1	increase					1165:1172	the increase	1161:1172	the increase of CIP concentration	1161:1193	From the macroscopic aspect, flocs were produced with the increase of CIP concentration during the reaction, adsorption combined with flocculation were related to the CIP removal.
34464865	4	39	theme	removal	712:718	arg1	efficiency					720:729	high removal efficiency	707:729	high removal efficiency (95.58%)	707:738	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	4	39	theme	removal	712:718	arg1	%					737:737	95.58%	732:737	95.58%	732:737	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	8	40	theme	cation	1384:1389	arg1	complexation					1391:1402	cation complexation	1384:1402	cation complexation among biocalcium-CIP	1384:1423	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	1	41	theme	dual	219:222	arg1	problems					224:231	the dual problems	215:231	the dual problems of bioaccumulation toxicity and antibiotic resistance	215:285	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	0	42	theme	superior	29:36	arg1	composite					38:46	a novel superior composite	21:46	a novel superior composite for ciprofloxacin removal	21:72	Chitin-biocalcium as a novel superior composite for ciprofloxacin removal: Synergism of adsorption and flocculation.
34464865	4	43	theme	superior	587:594	arg1	capacity					608:615	superior CIP removal capacity	587:615	superior CIP removal capacity of 2432 mg/g	587:628	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	6	44	theme	intraparticle	969:981	arg1	model					993:997	intraparticle diffusion model	969:997	intraparticle diffusion model	969:997	The kinetic experimental data was fitted well by pseudo-second-order and intraparticle diffusion model at different concentrations, revealing the removal was controlled by chemisorption and mass transport step.
34464865	5	45	theme	functional	796:805	arg1	groups					807:812	The functional groups	792:812	The functional groups in chitin and high content of biocalcium (Ca2+) endowed CC abundant active sites.	792:894	The functional groups in chitin and high content of biocalcium (Ca2+) endowed CC abundant active sites.
34464865	5	46	theme	high	828:831	arg1	content					833:839	chitin and high content	817:839	chitin and high content of biocalcium (Ca2+) endowed CC abundant active sites	817:893	The functional groups in chitin and high content of biocalcium (Ca2+) endowed CC abundant active sites.
34464865	0	47	theme	ciprofloxacin	52:64	arg1	removal					66:72	ciprofloxacin removal	52:72	ciprofloxacin removal	52:72	Chitin-biocalcium as a novel superior composite for ciprofloxacin removal: Synergism of adsorption and flocculation.
34464865	6	48	theme	experimental	908:919	arg1	data					921:924	The kinetic experimental data	896:924	The kinetic experimental data	896:924	The kinetic experimental data was fitted well by pseudo-second-order and intraparticle diffusion model at different concentrations, revealing the removal was controlled by chemisorption and mass transport step.
34464865	5	49	theme	abundant	873:880	arg1	sites					889:893	biocalcium (Ca2+) endowed CC abundant active sites	844:893	biocalcium (Ca2+) endowed CC abundant active sites	844:893	The functional groups in chitin and high content of biocalcium (Ca2+) endowed CC abundant active sites.
34464865	6	50	theme	kinetic	900:906	arg1	data					921:924	The kinetic experimental data	896:924	The kinetic experimental data	896:924	The kinetic experimental data was fitted well by pseudo-second-order and intraparticle diffusion model at different concentrations, revealing the removal was controlled by chemisorption and mass transport step.
34464865	7	51	theme	CIP	1177:1179	arg1	concentration					1181:1193	CIP concentration	1177:1193	CIP concentration	1177:1193	From the macroscopic aspect, flocs were produced with the increase of CIP concentration during the reaction, adsorption combined with flocculation were related to the CIP removal.
34464865	4	52	dep	25 °C	633:637	arg1	adsorption					640:649	adsorption	640:649	adsorption combined with flocculation	640:676	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	8	53	theme	chitin	1472:1477	arg1	groups					1462:1467	functional groups	1451:1467	functional groups of chitin and CIP	1451:1485	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	8	53	theme	chitin	1472:1477	arg1	CIP					1483:1485	CIP	1483:1485	CIP	1483:1485	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	8	53	theme	chitin	1472:1477	arg1	chitin					1472:1477	chitin	1472:1477	chitin	1472:1477	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	1	54	theme	ubiquitous	121:130	arg1	concern					200:206	attracting increasing concern	178:206	attracting increasing concern	178:206	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	1	54	theme	ubiquitous	121:130	arg1	antibiotics					140:150	The ubiquitous present antibiotics	117:150	The ubiquitous present antibiotics in aquatic environment	117:173	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	8	55	theme	hydrogen	1429:1436	arg1	bond					1438:1441	hydrogen bond	1429:1441	hydrogen bond between functional groups of chitin and CIP	1429:1485	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	5	56	theme	active	882:887	arg1	sites					889:893	biocalcium (Ca2+) endowed CC abundant active sites	844:893	biocalcium (Ca2+) endowed CC abundant active sites	844:893	The functional groups in chitin and high content of biocalcium (Ca2+) endowed CC abundant active sites.
34464865	3	57	used	utilized	508:515	arg2	methodology					486:496	Response surface methodology	469:496	Response surface methodology (RSM)	469:502	Response surface methodology (RSM) was utilized to optimize synthesis methodology.
34464865	3	57	used	utilized	508:515	arg2	RSM					499:501	RSM	499:501	RSM	499:501	Response surface methodology (RSM) was utilized to optimize synthesis methodology.
34464865	4	58	theme	adsorption	686:695	arg1	kinetics					697:704	rapid adsorption kinetics	680:704	rapid adsorption kinetics	680:704	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	1	59	theme	present	132:138	arg1	concern					200:206	attracting increasing concern	178:206	attracting increasing concern	178:206	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	1	59	theme	present	132:138	arg1	antibiotics					140:150	The ubiquitous present antibiotics	117:150	The ubiquitous present antibiotics in aquatic environment	117:173	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	4	60	theme	wide	744:747	arg1	adaptability					752:763	wide pH adaptability	744:763	wide pH adaptability (under pH range 4.0-10.0)	744:789	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	4	61	theme	2432 mg/g	620:628	arg1	capacity					608:615	superior CIP removal capacity	587:615	superior CIP removal capacity of 2432 mg/g	587:628	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	5	62	theme	sites	889:893	arg1	content					833:839	chitin and high content	817:839	chitin and high content of biocalcium (Ca2+) endowed CC abundant active sites	817:893	The functional groups in chitin and high content of biocalcium (Ca2+) endowed CC abundant active sites.
34464865	7	63	theme	CIP	1274:1276	arg1	removal					1278:1284	the CIP removal	1270:1284	the CIP removal	1270:1284	From the macroscopic aspect, flocs were produced with the increase of CIP concentration during the reaction, adsorption combined with flocculation were related to the CIP removal.
34464865	4	64	theme	pH	772:773	arg1	range					775:779	pH range 4.0-10.0	772:788	pH range 4.0-10.0	772:788	The optimized CC products featured superior CIP removal capacity of 2432 mg/g at 25 °C (adsorption combined with flocculation), rapid adsorption kinetics, high removal efficiency (95.58%) and wide pH adaptability (under pH range 4.0-10.0).
34464865	2	65	theme	facile	366:371	arg1	process					391:397	a facile alkali activation process	364:397	a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal	364:466	In this study, a low-cost chitin-biocalcium (CC) composite was developed by a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal.
34464865	1	66	theme	bioaccumulation	236:250	arg1	toxicity					252:259	bioaccumulation toxicity	236:259	bioaccumulation toxicity	236:259	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	6	67	theme	transport	1091:1099	arg1	step					1101:1104	mass transport step	1086:1104	mass transport step	1086:1104	The kinetic experimental data was fitted well by pseudo-second-order and intraparticle diffusion model at different concentrations, revealing the removal was controlled by chemisorption and mass transport step.
34464865	2	68	from	waste	410:414	arg1	process					391:397	a facile alkali activation process	364:397	a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal	364:466	In this study, a low-cost chitin-biocalcium (CC) composite was developed by a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal.
34464865	2	69	theme	alkali	373:378	arg1	process					391:397	a facile alkali activation process	364:397	a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal	364:466	In this study, a low-cost chitin-biocalcium (CC) composite was developed by a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal.
34464865	8	70	theme	bridging	1374:1381	arg1	cation					1367:1372	cation bridging	1367:1381	cation bridging	1367:1381	From the microcosmic aspect, the superior removal performance was attributed to cation bridging, cation complexation among biocalcium-CIP and hydrogen bond between functional groups of chitin and CIP.
34464865	1	71	theme	toxicity	252:259	arg1	problems					224:231	the dual problems	215:231	the dual problems of bioaccumulation toxicity and antibiotic resistance	215:285	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
34464865	0	72	dep	Chitin-biocalcium	0:16	arg1	Synergism					75:83	Synergism	75:83	Chitin-biocalcium as a novel superior composite for ciprofloxacin removal: Synergism of adsorption and flocculation.	0:115	Chitin-biocalcium as a novel superior composite for ciprofloxacin removal: Synergism of adsorption and flocculation.
34464865	1	73	theme	aquatic	155:161	arg1	environment					163:173	aquatic environment	155:173	aquatic environment	155:173	The ubiquitous present antibiotics in aquatic environment is attracting increasing concern due to the dual problems of bioaccumulation toxicity and antibiotic resistance.
32693145	2	0	theme	fungi	365:369	arg1	variety					343:349	a variety	341:349	a variety of pathogenic fungi	341:369	Citral, a monoterpene aldehyde, has been shown to inhibit the growth of a variety of pathogenic fungi by affecting mitochondrial structure.
32693145	2	0	theme	fungi	365:369	arg1	fungi					365:369	pathogenic fungi	354:369	pathogenic fungi	354:369	Citral, a monoterpene aldehyde, has been shown to inhibit the growth of a variety of pathogenic fungi by affecting mitochondrial structure.
32693145	4	1	theme	copolymer	610:618	arg1	microspheres					672:683	modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres	601:683	modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral	601:702	In this study, a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral was developed to increase and stabilize the bioavailability of this natural bioactive substance.
32693145	10	2	theme	non-loaded	1784:1793	arg1	microspheres					1798:1809	non-loaded CS microspheres	1784:1809	non-loaded CS microspheres	1784:1809	The hydrogel microspheres with incorporated citral exhibited effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis than non-loaded CS microspheres.
32693145	13	3	theme	promising	2217:2225	arg1	microspheres					2198:2209	The microspheres	2194:2209	The microspheres	2194:2209	The microspheres are a promising green antimicrobial agent against plant pathogens in crop protection and other fields.
32693145	13	3	theme	promising	2217:2225	arg1	agent					2247:2251	a promising green antimicrobial agent	2215:2251	a promising green antimicrobial agent against plant pathogens in crop protection and other fields	2215:2311	The microspheres are a promising green antimicrobial agent against plant pathogens in crop protection and other fields.
32693145	3	4	theme	chemical	442:449	arg1	instability					451:461	chemical instability	442:461	chemical instability	442:461	However, the high volatility and chemical instability of citral may restrict its applications in the agricultural industries.
32693145	1	5	theme	great	216:220	arg1	damage					222:227	great damage	216:227	great damage to the soil and ecological environment	216:266	The extensive use of chemical pesticides in agricultural production has caused great damage to the soil and ecological environment.
32693145	12	6	from	citral	2041:2046	arg1	preservation					2055:2066	the preservation	2051:2066	the preservation of picked fruits	2051:2083	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	7	7	theme	weight	1134:1139	arg1	ratio					1141:1145	CS/CMC weight ratio	1127:1145	CS/CMC weight ratio	1127:1145	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	7	7	theme	weight	1134:1139	arg1	concentration					1148:1160	concentration	1148:1160	concentration	1148:1160	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	4	8	theme	hydrogels	662:670	arg1	microspheres					672:683	modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres	601:683	modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral	601:702	In this study, a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral was developed to increase and stabilize the bioavailability of this natural bioactive substance.
32693145	1	9	theme	soil	236:239	arg1	environment					256:266	the soil and ecological environment	232:266	the soil and ecological environment	232:266	The extensive use of chemical pesticides in agricultural production has caused great damage to the soil and ecological environment.
32693145	6	10	theme	citral	1018:1023	arg1	group					1009:1013	the carbonyl group	996:1013	the carbonyl group of citral	996:1023	Citral was embedded into the microspheres by coupling the carbonyl group of citral with the amino group of CS to form a Schiff base structure.
32693145	6	10	theme	citral	1018:1023	arg1	citral					1018:1023	citral	1018:1023	citral	1018:1023	Citral was embedded into the microspheres by coupling the carbonyl group of citral with the amino group of CS to form a Schiff base structure.
32693145	10	11	theme	incorporated	1652:1663	arg1	citral					1665:1670	incorporated citral	1652:1670	incorporated citral	1652:1670	The hydrogel microspheres with incorporated citral exhibited effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis than non-loaded CS microspheres.
32693145	1	12	theme	ecological	245:254	arg1	environment					256:266	the soil and ecological environment	232:266	the soil and ecological environment	232:266	The extensive use of chemical pesticides in agricultural production has caused great damage to the soil and ecological environment.
32693145	12	13	theme	previous	2009:2016	arg1	applications					2018:2029	the previous applications	2005:2029	the previous applications of CS and citral in the preservation of picked fruits	2005:2083	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	11	14	theme	antifungal	1854:1863	arg1	effect					1865:1870	a good antifungal effect	1847:1870	a good antifungal effect	1847:1870	Moreover, CS/CMC-citral-MPs showed a good antifungal effect in vivo in reducing disease incidence caused by the plant pathogenic fungus Botrytis cinerea in Solanum lycopersicum.
32693145	9	15	theme	FTIR	1524:1527	arg1	spectra					1529:1535	FTIR spectra	1524:1535	FTIR spectra	1524:1535	Both the XRD and FTIR spectra indicated that the microspheres contain -C=N- covalent bonds between CS and citral.
32693145	6	16	theme	Schiff	1062:1067	arg1	structure					1074:1082	a Schiff base structure	1060:1082	a Schiff base structure	1060:1082	Citral was embedded into the microspheres by coupling the carbonyl group of citral with the amino group of CS to form a Schiff base structure.
32693145	5	17	theme	composite	817:825	arg1	microspheres					845:856	Polyelectrolyte composite scaffold hydrogel microspheres	801:856	Polyelectrolyte composite scaffold hydrogel microspheres	801:856	Polyelectrolyte composite scaffold hydrogel microspheres were synthesized by polycationic chitosan (CS) and polyanionic carboxymethyl (CMC).
32693145	1	18	theme	agricultural	181:192	arg1	production					194:203	agricultural production	181:203	agricultural production	181:203	The extensive use of chemical pesticides in agricultural production has caused great damage to the soil and ecological environment.
32693145	11	19	from	cinerea	1957:1963	arg1	lycopersicum					1976:1987	Solanum lycopersicum	1968:1987	Solanum lycopersicum	1968:1987	Moreover, CS/CMC-citral-MPs showed a good antifungal effect in vivo in reducing disease incidence caused by the plant pathogenic fungus Botrytis cinerea in Solanum lycopersicum.
32693145	5	20	theme	hydrogel	836:843	arg1	microspheres					845:856	Polyelectrolyte composite scaffold hydrogel microspheres	801:856	Polyelectrolyte composite scaffold hydrogel microspheres	801:856	Polyelectrolyte composite scaffold hydrogel microspheres were synthesized by polycationic chitosan (CS) and polyanionic carboxymethyl (CMC).
32693145	6	21	theme	CS	1049:1050	arg1	CS					1049:1050	CS	1049:1050	CS	1049:1050	Citral was embedded into the microspheres by coupling the carbonyl group of citral with the amino group of CS to form a Schiff base structure.
32693145	6	21	theme	CS	1049:1050	arg1	group					1040:1044	the amino group	1030:1044	the amino group of CS to form a Schiff base structure	1030:1082	Citral was embedded into the microspheres by coupling the carbonyl group of citral with the amino group of CS to form a Schiff base structure.
32693145	7	22	theme	%	1244:1244	arg1	loading					1231:1237	optimal loading	1223:1237	optimal loading of 68%	1223:1244	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	12	23	dep	embedded	2097:2104	arg1	Different					1990:1998	Different	1990:1998	Different	1990:1998	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	1	24	theme	pesticides	167:176	arg1	use					151:153	The extensive use	137:153	The extensive use of chemical pesticides in agricultural production	137:203	The extensive use of chemical pesticides in agricultural production has caused great damage to the soil and ecological environment.
32693145	8	25	theme	electron	1381:1388	arg1	SEM					1402:1404	SEM	1402:1404	SEM	1402:1404	X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were employed to confirm and characterize the structure and surface morphology of the microspheres.
32693145	8	25	theme	electron	1381:1388	arg1	microscopy					1390:1399	scanning electron microscopy	1372:1399	scanning electron microscopy (SEM)	1372:1405	X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were employed to confirm and characterize the structure and surface morphology of the microspheres.
32693145	10	26	theme	improved	1696:1703	arg1	effects					1728:1734	effective and improved in vitro antibacterial effects	1682:1734	effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis	1682:1777	The hydrogel microspheres with incorporated citral exhibited effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis than non-loaded CS microspheres.
32693145	9	27	theme	covalent	1583:1590	arg1	bonds					1592:1596	-C=N- covalent bonds	1577:1596	-C=N- covalent bonds between CS and citral	1577:1618	Both the XRD and FTIR spectra indicated that the microspheres contain -C=N- covalent bonds between CS and citral.
32693145	3	28	dep	volatility	427:436	arg1	the					418:420	the	418:420	the	418:420	However, the high volatility and chemical instability of citral may restrict its applications in the agricultural industries.
32693145	4	29	theme	bioactive	780:788	arg1	substance					790:798	this natural bioactive substance	767:798	this natural bioactive substance	767:798	In this study, a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral was developed to increase and stabilize the bioavailability of this natural bioactive substance.
32693145	10	30	theme	effective	1682:1690	arg1	effects					1728:1734	effective and improved in vitro antibacterial effects	1682:1734	effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis	1682:1777	The hydrogel microspheres with incorporated citral exhibited effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis than non-loaded CS microspheres.
32693145	0	31	theme	Citral-loaded	0:12	arg1	microspheres					66:77	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres	0:77	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres with	0:82	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres with improved antimicrobial effects for plant protection.
32693145	1	32	from	use	151:153	arg1	production					194:203	agricultural production	181:203	agricultural production	181:203	The extensive use of chemical pesticides in agricultural production has caused great damage to the soil and ecological environment.
32693145	4	33	theme	facile	564:569	arg1	method					571:576	a concise and facile method	550:576	a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral	550:702	In this study, a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral was developed to increase and stabilize the bioavailability of this natural bioactive substance.
32693145	0	34	theme	cellulose	37:45	arg1	microspheres					66:77	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres	0:77	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres with	0:82	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres with improved antimicrobial effects for plant protection.
32693145	13	35	theme	other	2300:2304	arg1	fields					2306:2311	other fields	2300:2311	other fields	2300:2311	The microspheres are a promising green antimicrobial agent against plant pathogens in crop protection and other fields.
32693145	1	36	theme	extensive	141:149	arg1	use					151:153	The extensive use	137:153	The extensive use of chemical pesticides in agricultural production	137:203	The extensive use of chemical pesticides in agricultural production has caused great damage to the soil and ecological environment.
32693145	0	37	theme	hydrogel	57:64	arg1	microspheres					66:77	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres	0:77	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres with	0:82	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres with improved antimicrobial effects for plant protection.
32693145	13	38	theme	plant	2261:2265	arg1	pathogens					2267:2275	plant pathogens	2261:2275	plant pathogens	2261:2275	The microspheres are a promising green antimicrobial agent against plant pathogens in crop protection and other fields.
32693145	7	39	theme	loading	1187:1193	arg1	ratio					1195:1199	the loading ratio	1183:1199	the loading ratio	1183:1199	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	13	40	from	agent	2247:2251	arg1	protection					2285:2294	crop protection	2280:2294	crop protection	2280:2294	The microspheres are a promising green antimicrobial agent against plant pathogens in crop protection and other fields.
32693145	13	40	from	agent	2247:2251	arg1	fields					2306:2311	other fields	2300:2311	other fields	2300:2311	The microspheres are a promising green antimicrobial agent against plant pathogens in crop protection and other fields.
32693145	0	41	theme	antimicrobial	93:105	arg1	effects					107:113	antimicrobial effects	93:113	antimicrobial effects	93:113	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres with improved antimicrobial effects for plant protection.
32693145	2	42	theme	pathogenic	354:363	arg1	fungi					365:369	pathogenic fungi	354:369	pathogenic fungi	354:369	Citral, a monoterpene aldehyde, has been shown to inhibit the growth of a variety of pathogenic fungi by affecting mitochondrial structure.
32693145	3	43	theme	agricultural	510:521	arg1	industries					523:532	the agricultural industries	506:532	the agricultural industries	506:532	However, the high volatility and chemical instability of citral may restrict its applications in the agricultural industries.
32693145	4	44	theme	concise	552:558	arg1	method					571:576	a concise and facile method	550:576	a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral	550:702	In this study, a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral was developed to increase and stabilize the bioavailability of this natural bioactive substance.
32693145	3	45	from	applications	490:501	arg1	industries					523:532	the agricultural industries	506:532	the agricultural industries	506:532	However, the high volatility and chemical instability of citral may restrict its applications in the agricultural industries.
32693145	2	46	theme	variety	343:349	arg1	growth					331:336	the growth	327:336	the growth of a variety of pathogenic fungi	327:369	Citral, a monoterpene aldehyde, has been shown to inhibit the growth of a variety of pathogenic fungi by affecting mitochondrial structure.
32693145	13	47	theme	green	2227:2231	arg1	microspheres					2198:2209	The microspheres	2194:2209	The microspheres	2194:2209	The microspheres are a promising green antimicrobial agent against plant pathogens in crop protection and other fields.
32693145	13	47	theme	green	2227:2231	arg1	agent					2247:2251	a promising green antimicrobial agent	2215:2251	a promising green antimicrobial agent against plant pathogens in crop protection and other fields	2215:2311	The microspheres are a promising green antimicrobial agent against plant pathogens in crop protection and other fields.
32693145	8	48	dep	Fourier	1320:1326	arg1	transform					1328:1336	transform	1328:1336	transform infrared (FT-IR) spectroscopy	1328:1366	X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were employed to confirm and characterize the structure and surface morphology of the microspheres.
32693145	4	49	theme	chitosan/carboxymethyl	620:641	arg1	microspheres					672:683	modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres	601:683	modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral	601:702	In this study, a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral was developed to increase and stabilize the bioavailability of this natural bioactive substance.
32693145	2	50	theme	mitochondrial	384:396	arg1	structure					398:406	mitochondrial structure	384:406	mitochondrial structure	384:406	Citral, a monoterpene aldehyde, has been shown to inhibit the growth of a variety of pathogenic fungi by affecting mitochondrial structure.
32693145	7	51	from	effects	1089:1095	arg1	ratio					1195:1199	the loading ratio	1183:1199	the loading ratio	1183:1199	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	9	52	contain	contain	1569:1575	arg1	microspheres					1556:1567	the microspheres	1552:1567	the microspheres	1552:1567	Both the XRD and FTIR spectra indicated that the microspheres contain -C=N- covalent bonds between CS and citral.
32693145	9	52	contain	contain	1569:1575	arg2	bonds					1592:1596	-C=N- covalent bonds	1577:1596	-C=N- covalent bonds between CS and citral	1577:1618	Both the XRD and FTIR spectra indicated that the microspheres contain -C=N- covalent bonds between CS and citral.
32693145	5	53	theme	scaffold	827:834	arg1	microspheres					845:856	Polyelectrolyte composite scaffold hydrogel microspheres	801:856	Polyelectrolyte composite scaffold hydrogel microspheres	801:856	Polyelectrolyte composite scaffold hydrogel microspheres were synthesized by polycationic chitosan (CS) and polyanionic carboxymethyl (CMC).
32693145	7	54	theme	CMC	1165:1167	arg1	ratio					1141:1145	CS/CMC weight ratio	1127:1145	CS/CMC weight ratio	1127:1145	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	7	54	theme	CMC	1165:1167	arg1	concentration					1148:1160	concentration	1148:1160	concentration	1148:1160	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	12	55	theme	fruits	2078:2083	arg1	preservation					2055:2066	the preservation	2051:2066	the preservation of picked fruits	2051:2083	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	7	56	theme	single-factor	1268:1280	arg1	experiments					1282:1292	single-factor experiments	1268:1292	single-factor experiments	1268:1292	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	10	57	theme	CS	1795:1796	arg1	microspheres					1798:1809	non-loaded CS microspheres	1784:1809	non-loaded CS microspheres	1784:1809	The hydrogel microspheres with incorporated citral exhibited effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis than non-loaded CS microspheres.
32693145	12	58	theme	citral	2041:2046	arg1	applications					2018:2029	the previous applications	2005:2029	the previous applications of CS and citral in the preservation of picked fruits	2005:2083	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	12	59	from	preservation	2055:2066	arg1	applications					2018:2029	the previous applications	2005:2029	the previous applications of CS and citral in the preservation of picked fruits	2005:2083	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	4	60	theme	modified	601:608	arg1	microspheres					672:683	modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres	601:683	modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral	601:702	In this study, a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral was developed to increase and stabilize the bioavailability of this natural bioactive substance.
32693145	11	61	theme	disease	1892:1898	arg1	incidence					1900:1908	disease incidence	1892:1908	disease incidence caused by the plant pathogenic fungus Botrytis cinerea in Solanum lycopersicum	1892:1987	Moreover, CS/CMC-citral-MPs showed a good antifungal effect in vivo in reducing disease incidence caused by the plant pathogenic fungus Botrytis cinerea in Solanum lycopersicum.
32693145	12	62	theme	Botrytis	2176:2183	arg1	cinerea					2185:2191	Botrytis cinerea	2176:2191	Botrytis cinerea	2176:2191	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	10	63	theme	hydrogel	1625:1632	arg1	microspheres					1634:1645	The hydrogel microspheres	1621:1645	The hydrogel microspheres with incorporated citral	1621:1670	The hydrogel microspheres with incorporated citral exhibited effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis than non-loaded CS microspheres.
32693145	7	64	theme	CS/CMC	1127:1132	arg1	ratio					1141:1145	CS/CMC weight ratio	1127:1145	CS/CMC weight ratio	1127:1145	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	7	64	theme	CS/CMC	1127:1132	arg1	concentration					1148:1160	concentration	1148:1160	concentration	1148:1160	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	6	65	theme	amino	1034:1038	arg1	CS					1049:1050	CS	1049:1050	CS	1049:1050	Citral was embedded into the microspheres by coupling the carbonyl group of citral with the amino group of CS to form a Schiff base structure.
32693145	6	65	theme	amino	1034:1038	arg1	group					1040:1044	the amino group	1030:1044	the amino group of CS to form a Schiff base structure	1030:1082	Citral was embedded into the microspheres by coupling the carbonyl group of citral with the amino group of CS to form a Schiff base structure.
32693145	11	66	theme	good	1849:1852	arg1	effect					1865:1870	a good antifungal effect	1847:1870	a good antifungal effect	1847:1870	Moreover, CS/CMC-citral-MPs showed a good antifungal effect in vivo in reducing disease incidence caused by the plant pathogenic fungus Botrytis cinerea in Solanum lycopersicum.
32693145	7	67	theme	parameters	1106:1115	arg1	effects					1089:1095	The effects	1085:1095	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio	1085:1199	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	12	68	theme	CS	2034:2035	arg1	applications					2018:2029	the previous applications	2005:2029	the previous applications of CS and citral in the preservation of picked fruits	2005:2083	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	8	69	theme	surface	1467:1473	arg1	morphology					1475:1484	surface morphology	1467:1484	surface morphology	1467:1484	X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were employed to confirm and characterize the structure and surface morphology of the microspheres.
32693145	8	70	theme	X-ray	1295:1299	arg1	diffraction					1301:1311	X-ray diffraction	1295:1311	X-ray diffraction (XRD)	1295:1317	X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were employed to confirm and characterize the structure and surface morphology of the microspheres.
32693145	8	70	theme	X-ray	1295:1299	arg1	XRD					1314:1316	XRD	1314:1316	XRD	1314:1316	X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were employed to confirm and characterize the structure and surface morphology of the microspheres.
32693145	5	71	theme	polyanionic	909:919	arg1	CMC					936:938	CMC	936:938	CMC	936:938	Polyelectrolyte composite scaffold hydrogel microspheres were synthesized by polycationic chitosan (CS) and polyanionic carboxymethyl (CMC).
32693145	5	71	theme	polyanionic	909:919	arg1	carboxymethyl					921:933	polyanionic carboxymethyl	909:933	polyanionic carboxymethyl (CMC)	909:939	Polyelectrolyte composite scaffold hydrogel microspheres were synthesized by polycationic chitosan (CS) and polyanionic carboxymethyl (CMC).
32693145	4	72	theme	microspheres	672:683	arg1	preparation					586:596	the preparation	582:596	the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral	582:702	In this study, a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral was developed to increase and stabilize the bioavailability of this natural bioactive substance.
32693145	8	73	dep	structure	1453:1461	arg1	the					1449:1451	the	1449:1451	the	1449:1451	X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were employed to confirm and characterize the structure and surface morphology of the microspheres.
32693145	6	74	theme	carbonyl	1000:1007	arg1	group					1009:1013	the carbonyl group	996:1013	the carbonyl group of citral	996:1023	Citral was embedded into the microspheres by coupling the carbonyl group of citral with the amino group of CS to form a Schiff base structure.
32693145	6	74	theme	carbonyl	1000:1007	arg1	citral					1018:1023	citral	1018:1023	citral	1018:1023	Citral was embedded into the microspheres by coupling the carbonyl group of citral with the amino group of CS to form a Schiff base structure.
32693145	8	75	theme	microspheres	1493:1504	arg1	morphology					1475:1484	surface morphology	1467:1484	surface morphology	1467:1484	X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were employed to confirm and characterize the structure and surface morphology of the microspheres.
32693145	8	75	theme	microspheres	1493:1504	arg1	structure					1453:1461	structure	1453:1461	structure	1453:1461	X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were employed to confirm and characterize the structure and surface morphology of the microspheres.
32693145	12	76	theme	CS/CMC	2111:2116	arg1	microspheres					2118:2129	CS/CMC microspheres	2111:2129	CS/CMC microspheres	2111:2129	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	1	77	theme	chemical	158:165	arg1	pesticides					167:176	chemical pesticides	158:176	chemical pesticides	158:176	The extensive use of chemical pesticides in agricultural production has caused great damage to the soil and ecological environment.
32693145	6	78	theme	base	1069:1072	arg1	structure					1074:1082	a Schiff base structure	1060:1082	a Schiff base structure	1060:1082	Citral was embedded into the microspheres by coupling the carbonyl group of citral with the amino group of CS to form a Schiff base structure.
32693145	5	79	theme	Polyelectrolyte	801:815	arg1	microspheres					845:856	Polyelectrolyte composite scaffold hydrogel microspheres	801:856	Polyelectrolyte composite scaffold hydrogel microspheres	801:856	Polyelectrolyte composite scaffold hydrogel microspheres were synthesized by polycationic chitosan (CS) and polyanionic carboxymethyl (CMC).
32693145	2	80	theme	monoterpene	279:289	arg1	Citral					269:274	Citral	269:274	Citral	269:274	Citral, a monoterpene aldehyde, has been shown to inhibit the growth of a variety of pathogenic fungi by affecting mitochondrial structure.
32693145	2	80	theme	monoterpene	279:289	arg1	aldehyde					291:298	a monoterpene aldehyde	277:298	a monoterpene aldehyde	277:298	Citral, a monoterpene aldehyde, has been shown to inhibit the growth of a variety of pathogenic fungi by affecting mitochondrial structure.
32693145	12	81	theme	plant	2151:2155	arg1	protection					2157:2166	improved plant protection	2142:2166	improved plant protection against Botrytis cinerea	2142:2191	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	8	82	theme	infrared	1338:1345	arg1	spectroscopy					1355:1366	infrared (FT-IR) spectroscopy	1338:1366	infrared (FT-IR) spectroscopy	1338:1366	X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were employed to confirm and characterize the structure and surface morphology of the microspheres.
32693145	0	83	theme	plant	119:123	arg1	protection					125:134	plant protection	119:134	plant protection	119:134	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres with improved antimicrobial effects for plant protection.
32693145	8	84	theme	FT-IR	1348:1352	arg1	spectroscopy					1355:1366	infrared (FT-IR) spectroscopy	1338:1366	infrared (FT-IR) spectroscopy	1338:1366	X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were employed to confirm and characterize the structure and surface morphology of the microspheres.
32693145	7	85	theme	optimal	1223:1229	arg1	loading					1231:1237	optimal loading	1223:1237	optimal loading of 68%	1223:1244	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	12	86	theme	improved	2142:2149	arg1	protection					2157:2166	improved plant protection	2142:2166	improved plant protection against Botrytis cinerea	2142:2191	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	9	87	theme	-C=N-	1577:1581	arg1	bonds					1592:1596	-C=N- covalent bonds	1577:1596	-C=N- covalent bonds between CS and citral	1577:1618	Both the XRD and FTIR spectra indicated that the microspheres contain -C=N- covalent bonds between CS and citral.
32693145	8	88	theme	scanning	1372:1379	arg1	SEM					1402:1404	SEM	1402:1404	SEM	1402:1404	X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were employed to confirm and characterize the structure and surface morphology of the microspheres.
32693145	8	88	theme	scanning	1372:1379	arg1	microscopy					1390:1399	scanning electron microscopy	1372:1399	scanning electron microscopy (SEM)	1372:1405	X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were employed to confirm and characterize the structure and surface morphology of the microspheres.
32693145	3	89	theme	citral	466:471	arg1	volatility					427:436	high volatility	422:436	high volatility	422:436	However, the high volatility and chemical instability of citral may restrict its applications in the agricultural industries.
32693145	3	89	theme	citral	466:471	arg1	instability					451:461	chemical instability	442:461	chemical instability	442:461	However, the high volatility and chemical instability of citral may restrict its applications in the agricultural industries.
32693145	5	90	theme	polycationic	878:889	arg1	chitosan					891:898	polycationic chitosan	878:898	polycationic chitosan (CS)	878:903	Polyelectrolyte composite scaffold hydrogel microspheres were synthesized by polycationic chitosan (CS) and polyanionic carboxymethyl (CMC).
32693145	5	90	theme	polycationic	878:889	arg1	CS					901:902	CS	901:902	CS	901:902	Polyelectrolyte composite scaffold hydrogel microspheres were synthesized by polycationic chitosan (CS) and polyanionic carboxymethyl (CMC).
32693145	11	91	theme	pathogenic	1930:1939	arg1	fungus					1941:1946	plant pathogenic fungus	1924:1946	the plant pathogenic fungus Botrytis cinerea in Solanum lycopersicum	1920:1987	Moreover, CS/CMC-citral-MPs showed a good antifungal effect in vivo in reducing disease incidence caused by the plant pathogenic fungus Botrytis cinerea in Solanum lycopersicum.
32693145	4	92	theme	natural	772:778	arg1	substance					790:798	this natural bioactive substance	767:798	this natural bioactive substance	767:798	In this study, a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral was developed to increase and stabilize the bioavailability of this natural bioactive substance.
32693145	11	93	theme	fungus	1941:1946	arg1	cinerea					1957:1963	the plant pathogenic fungus Botrytis cinerea	1920:1963	the plant pathogenic fungus Botrytis cinerea in Solanum lycopersicum	1920:1987	Moreover, CS/CMC-citral-MPs showed a good antifungal effect in vivo in reducing disease incidence caused by the plant pathogenic fungus Botrytis cinerea in Solanum lycopersicum.
32693145	0	94	theme	copolymer	47:55	arg1	microspheres					66:77	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres	0:77	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres with	0:82	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres with improved antimicrobial effects for plant protection.
32693145	4	95	theme	substance	790:798	arg1	bioavailability					748:762	the bioavailability	744:762	the bioavailability of this natural bioactive substance	744:798	In this study, a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral was developed to increase and stabilize the bioavailability of this natural bioactive substance.
32693145	10	96	theme	antibacterial	1714:1726	arg1	effects					1728:1734	effective and improved in vitro antibacterial effects	1682:1734	effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis	1682:1777	The hydrogel microspheres with incorporated citral exhibited effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis than non-loaded CS microspheres.
32693145	12	97	from	CS	2034:2035	arg1	preservation					2055:2066	the preservation	2051:2066	the preservation of picked fruits	2051:2083	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	11	98	theme	Botrytis	1948:1955	arg1	cinerea					1957:1963	the plant pathogenic fungus Botrytis cinerea	1920:1963	the plant pathogenic fungus Botrytis cinerea in Solanum lycopersicum	1920:1987	Moreover, CS/CMC-citral-MPs showed a good antifungal effect in vivo in reducing disease incidence caused by the plant pathogenic fungus Botrytis cinerea in Solanum lycopersicum.
32693145	10	99	dep	in	1705:1706	arg1	vitro					1708:1712	vitro	1708:1712	vitro	1708:1712	The hydrogel microspheres with incorporated citral exhibited effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis than non-loaded CS microspheres.
32693145	10	100	theme	in	1705:1706	arg1	effects					1728:1734	effective and improved in vitro antibacterial effects	1682:1734	effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis	1682:1777	The hydrogel microspheres with incorporated citral exhibited effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis than non-loaded CS microspheres.
32693145	7	101	theme	citral	1173:1178	arg1	ratio					1141:1145	CS/CMC weight ratio	1127:1145	CS/CMC weight ratio	1127:1145	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	7	101	theme	citral	1173:1178	arg1	concentration					1148:1160	concentration	1148:1160	concentration	1148:1160	The effects of three parameters including CS/CMC weight ratio, concentration of CMC and citral on the loading ratio were investigated and optimal loading of 68% was achieved based on single-factor experiments.
32693145	12	102	from	applications	2018:2029	arg1	Different					1990:1998	Different	1990:1998	Different	1990:1998	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	12	102	from	applications	2018:2029	arg1	preservation					2055:2066	the preservation	2051:2066	the preservation of picked fruits	2051:2083	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	3	103	theme	high	422:425	arg1	volatility					427:436	high volatility	422:436	high volatility	422:436	However, the high volatility and chemical instability of citral may restrict its applications in the agricultural industries.
32693145	13	104	theme	crop	2280:2283	arg1	protection					2285:2294	crop protection	2280:2294	crop protection	2280:2294	The microspheres are a promising green antimicrobial agent against plant pathogens in crop protection and other fields.
32693145	6	105	with	coupling	987:994	arg1	CS					1049:1050	CS	1049:1050	CS	1049:1050	Citral was embedded into the microspheres by coupling the carbonyl group of citral with the amino group of CS to form a Schiff base structure.
32693145	6	105	with	coupling	987:994	arg1	group					1040:1044	the amino group	1030:1044	the amino group of CS to form a Schiff base structure	1030:1082	Citral was embedded into the microspheres by coupling the carbonyl group of citral with the amino group of CS to form a Schiff base structure.
32693145	4	106	theme	cellulose	643:651	arg1	microspheres					672:683	modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres	601:683	modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral	601:702	In this study, a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral was developed to increase and stabilize the bioavailability of this natural bioactive substance.
32693145	11	107	theme	plant	1924:1928	arg1	fungus					1941:1946	plant pathogenic fungus	1924:1946	the plant pathogenic fungus Botrytis cinerea in Solanum lycopersicum	1920:1987	Moreover, CS/CMC-citral-MPs showed a good antifungal effect in vivo in reducing disease incidence caused by the plant pathogenic fungus Botrytis cinerea in Solanum lycopersicum.
32693145	13	108	theme	antimicrobial	2233:2245	arg1	microspheres					2198:2209	The microspheres	2194:2209	The microspheres	2194:2209	The microspheres are a promising green antimicrobial agent against plant pathogens in crop protection and other fields.
32693145	13	108	theme	antimicrobial	2233:2245	arg1	agent					2247:2251	a promising green antimicrobial agent	2215:2251	a promising green antimicrobial agent against plant pathogens in crop protection and other fields	2215:2311	The microspheres are a promising green antimicrobial agent against plant pathogens in crop protection and other fields.
32693145	12	109	theme	picked	2071:2076	arg1	fruits					2078:2083	picked fruits	2071:2083	picked fruits	2071:2083	Different from the previous applications of CS and citral in the preservation of picked fruits, citral was embedded into CS/CMC microspheres to achieve improved plant protection against Botrytis cinerea.
32693145	10	110	with	microspheres	1634:1645	arg1	citral					1665:1670	incorporated citral	1652:1670	incorporated citral	1652:1670	The hydrogel microspheres with incorporated citral exhibited effective and improved in vitro antibacterial effects against E. coli, S. aureus and B. subtilis than non-loaded CS microspheres.
32693145	4	111	theme	CS/CMC	654:659	arg1	microspheres					672:683	modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres	601:683	modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral	601:702	In this study, a concise and facile method for the preparation of modified copolymer chitosan/carboxymethyl cellulose (CS/CMC) hydrogels microspheres loaded with citral was developed to increase and stabilize the bioavailability of this natural bioactive substance.
32693145	0	112	theme	chitosan/carboxymethyl	14:35	arg1	microspheres					66:77	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres	0:77	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres with	0:82	Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres with improved antimicrobial effects for plant protection.
33559657	8	0	theme	osteogenic	1130:1139	arg1	activity					1141:1148	osteogenic activity	1130:1148	osteogenic activity	1130:1148	More importantly, the strontium ions endow the hydrogel with osteogenic activity.
33559657	6	1	theme	stable	899:904	arg1	crosslinkages					915:927	stable chemical crosslinkages	899:927	stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA	899:978	Under the simulated oxidation conditions in vivo, the injectable hydrogel can form stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA.
33559657	1	2	with	hydrogels	148:156	arg1	adhesivity					178:187	adhesivity	178:187	adhesivity	178:187	Numerous efforts have been made to prepare hydrogels with injectability, adhesivity and osteogenic activity for bone regeneration.
33559657	1	2	with	hydrogels	148:156	arg1	activity					204:211	osteogenic activity	193:211	osteogenic activity	193:211	Numerous efforts have been made to prepare hydrogels with injectability, adhesivity and osteogenic activity for bone regeneration.
33559657	1	2	with	hydrogels	148:156	arg1	injectability					163:175	injectability	163:175	injectability	163:175	Numerous efforts have been made to prepare hydrogels with injectability, adhesivity and osteogenic activity for bone regeneration.
33559657	10	3	theme	bone	1485:1488	arg1	engineering					1497:1507	bone tissue engineering	1485:1507	bone tissue engineering in clinical applications	1485:1532	This simple hydrogel constructed by using a binary component has achieved several necessary functions, and is expected to be used as a scaffold for bone tissue engineering in clinical applications.
33559657	10	4	used	used	1462:1465	arg2	hydrogel					1349:1356	This simple hydrogel	1337:1356	This simple hydrogel constructed by using a binary component	1337:1396	This simple hydrogel constructed by using a binary component has achieved several necessary functions, and is expected to be used as a scaffold for bone tissue engineering in clinical applications.
33559657	10	4	used	used	1462:1465	arg2	scaffold					1472:1479	a scaffold	1470:1479	a scaffold for bone tissue engineering in clinical applications	1470:1532	This simple hydrogel constructed by using a binary component has achieved several necessary functions, and is expected to be used as a scaffold for bone tissue engineering in clinical applications.
33559657	9	5	theme	strontium	1191:1199	arg1	hydrogel					1212:1219	the strontium containing hydrogel	1187:1219	the strontium containing hydrogel	1187:1219	As indicated by animal experiments, the strontium containing hydrogel scaffolds help to treat rat bone defects within 8 weeks compared to hydrogels without strontium and control groups.
33559657	9	6	theme	animal	1167:1172	arg1	experiments					1174:1184	animal experiments	1167:1184	animal experiments	1167:1184	As indicated by animal experiments, the strontium containing hydrogel scaffolds help to treat rat bone defects within 8 weeks compared to hydrogels without strontium and control groups.
33559657	10	7	theme	simple	1342:1347	arg1	scaffold					1472:1479	a scaffold	1470:1479	a scaffold for bone tissue engineering in clinical applications	1470:1532	This simple hydrogel constructed by using a binary component has achieved several necessary functions, and is expected to be used as a scaffold for bone tissue engineering in clinical applications.
33559657	10	7	theme	simple	1342:1347	arg1	hydrogel					1349:1356	This simple hydrogel	1337:1356	This simple hydrogel constructed by using a binary component	1337:1396	This simple hydrogel constructed by using a binary component has achieved several necessary functions, and is expected to be used as a scaffold for bone tissue engineering in clinical applications.
33559657	4	8	theme	amidation	581:589	arg1	reaction					591:598	amidation reaction	581:598	amidation reaction	581:598	Dopamine (DA) is first grafted to alginate (Alg) by amidation reaction to give Alg-DA.
33559657	0	9	theme	bone	86:89	arg1	regeneration					91:102	bone regeneration	86:102	bone regeneration	86:102	A simple hydrogel scaffold with injectability, adhesivity and osteogenic activity for bone regeneration.
33559657	7	10	theme	catechol	998:1005	arg1	groups					1007:1012	the catechol groups	994:1012	the catechol groups	994:1012	In addition, the catechol groups endow the hydrogel with significant tissue adhesivity.
33559657	8	11	with	hydrogel	1116:1123	arg1	activity					1141:1148	osteogenic activity	1130:1148	osteogenic activity	1130:1148	More importantly, the strontium ions endow the hydrogel with osteogenic activity.
33559657	10	12	from	engineering	1497:1507	arg1	applications					1521:1532	clinical applications	1512:1532	clinical applications	1512:1532	This simple hydrogel constructed by using a binary component has achieved several necessary functions, and is expected to be used as a scaffold for bone tissue engineering in clinical applications.
33559657	6	13	theme	injectable	870:879	arg1	hydrogel					881:888	the injectable hydrogel	866:888	the injectable hydrogel	866:888	Under the simulated oxidation conditions in vivo, the injectable hydrogel can form stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA.
33559657	6	14	from	Alg-DA	973:978	arg1	presence					942:949	the presence	938:949	the presence of catechol groups on Alg-DA	938:978	Under the simulated oxidation conditions in vivo, the injectable hydrogel can form stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA.
33559657	9	15	theme	control	1321:1327	arg1	groups					1329:1334	control groups	1321:1334	control groups	1321:1334	As indicated by animal experiments, the strontium containing hydrogel scaffolds help to treat rat bone defects within 8 weeks compared to hydrogels without strontium and control groups.
33559657	3	16	theme	multifunctional	445:459	arg1	hydrogel					461:468	a multifunctional hydrogel	443:468	a multifunctional hydrogel with a binary component	443:492	In this study, a multifunctional hydrogel with a binary component is prepared for bone regeneration.
33559657	10	17	theme	necessary	1419:1427	arg1	functions					1429:1437	several necessary functions	1411:1437	several necessary functions	1411:1437	This simple hydrogel constructed by using a binary component has achieved several necessary functions, and is expected to be used as a scaffold for bone tissue engineering in clinical applications.
33559657	2	18	theme	batch	410:414	arg1	production					416:425	batch production	410:425	batch production	410:425	However, current hydrogels with these characteristics have limited application in clinical translation due to their complex chemical compositions, which causes difficulty in batch production.
33559657	0	19	theme	simple	2:7	arg1	scaffold					18:25	A simple hydrogel scaffold	0:25	A simple hydrogel scaffold with injectability, adhesivity and osteogenic activity for bone regeneration	0:102	A simple hydrogel scaffold with injectability, adhesivity and osteogenic activity for bone regeneration.
33559657	10	20	theme	clinical	1512:1519	arg1	applications					1521:1532	clinical applications	1512:1532	clinical applications	1512:1532	This simple hydrogel constructed by using a binary component has achieved several necessary functions, and is expected to be used as a scaffold for bone tissue engineering in clinical applications.
33559657	5	21	theme	dynamic	738:744	arg1	bonds					752:756	the dynamic ionic bonds	734:756	the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA	734:813	Then an injectable hydrogel is facilely prepared by mixing strontium ions with the Alg-DA aqueous solution, utilizing the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA.
33559657	6	22	from	groups	963:968	arg1	Alg-DA					973:978	Alg-DA	973:978	Alg-DA	973:978	Under the simulated oxidation conditions in vivo, the injectable hydrogel can form stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA.
33559657	6	23	theme	groups	963:968	arg1	presence					942:949	the presence	938:949	the presence of catechol groups on Alg-DA	938:978	Under the simulated oxidation conditions in vivo, the injectable hydrogel can form stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA.
33559657	5	24	theme	injectable	624:633	arg1	hydrogel					635:642	Then an injectable hydrogel	616:642	Then an injectable hydrogel	616:642	Then an injectable hydrogel is facilely prepared by mixing strontium ions with the Alg-DA aqueous solution, utilizing the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA.
33559657	9	25	theme	containing	1201:1210	arg1	hydrogel					1212:1219	the strontium containing hydrogel	1187:1219	the strontium containing hydrogel	1187:1219	As indicated by animal experiments, the strontium containing hydrogel scaffolds help to treat rat bone defects within 8 weeks compared to hydrogels without strontium and control groups.
33559657	9	26	theme	rat	1245:1247	arg1	defects					1254:1260	rat bone defects	1245:1260	rat bone defects within 8 weeks	1245:1275	As indicated by animal experiments, the strontium containing hydrogel scaffolds help to treat rat bone defects within 8 weeks compared to hydrogels without strontium and control groups.
33559657	7	27	with	hydrogel	1024:1031	arg1	adhesivity					1057:1066	significant tissue adhesivity	1038:1066	significant tissue adhesivity	1038:1066	In addition, the catechol groups endow the hydrogel with significant tissue adhesivity.
33559657	6	28	theme	catechol	954:961	arg1	groups					963:968	catechol groups	954:968	catechol groups on Alg-DA	954:978	Under the simulated oxidation conditions in vivo, the injectable hydrogel can form stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA.
33559657	7	29	theme	tissue	1050:1055	arg1	adhesivity					1057:1066	significant tissue adhesivity	1038:1066	significant tissue adhesivity	1038:1066	In addition, the catechol groups endow the hydrogel with significant tissue adhesivity.
33559657	2	30	theme	clinical	318:325	arg1	translation					327:337	clinical translation	318:337	clinical translation	318:337	However, current hydrogels with these characteristics have limited application in clinical translation due to their complex chemical compositions, which causes difficulty in batch production.
33559657	3	31	theme	binary	477:482	arg1	component					484:492	a binary component	475:492	a binary component	475:492	In this study, a multifunctional hydrogel with a binary component is prepared for bone regeneration.
33559657	0	32	theme	hydrogel	9:16	arg1	scaffold					18:25	A simple hydrogel scaffold	0:25	A simple hydrogel scaffold with injectability, adhesivity and osteogenic activity for bone regeneration	0:102	A simple hydrogel scaffold with injectability, adhesivity and osteogenic activity for bone regeneration.
33559657	6	33	from	presence	942:949	arg1	Alg-DA					973:978	Alg-DA	973:978	Alg-DA	973:978	Under the simulated oxidation conditions in vivo, the injectable hydrogel can form stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA.
33559657	1	34	theme	Numerous	105:112	arg1	efforts					114:120	Numerous efforts	105:120	Numerous efforts	105:120	Numerous efforts have been made to prepare hydrogels with injectability, adhesivity and osteogenic activity for bone regeneration.
33559657	10	35	theme	several	1411:1417	arg1	functions					1429:1437	several necessary functions	1411:1437	several necessary functions	1411:1437	This simple hydrogel constructed by using a binary component has achieved several necessary functions, and is expected to be used as a scaffold for bone tissue engineering in clinical applications.
33559657	3	36	theme	bone	510:513	arg1	regeneration					515:526	bone regeneration	510:526	bone regeneration	510:526	In this study, a multifunctional hydrogel with a binary component is prepared for bone regeneration.
33559657	5	37	theme	Alg-DA	699:704	arg1	solution					714:721	the Alg-DA aqueous solution	695:721	the Alg-DA aqueous solution	695:721	Then an injectable hydrogel is facilely prepared by mixing strontium ions with the Alg-DA aqueous solution, utilizing the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA.
33559657	6	38	theme	in	857:858	arg1	conditions					846:855	the simulated oxidation conditions	822:855	the simulated oxidation conditions in vivo	822:863	Under the simulated oxidation conditions in vivo, the injectable hydrogel can form stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA.
33559657	5	39	theme	strontium	770:778	arg1	ions					780:783	the strontium ions	766:783	the strontium ions	766:783	Then an injectable hydrogel is facilely prepared by mixing strontium ions with the Alg-DA aqueous solution, utilizing the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA.
33559657	2	40	with	hydrogels	253:261	arg1	characteristics					274:288	these characteristics	268:288	these characteristics	268:288	However, current hydrogels with these characteristics have limited application in clinical translation due to their complex chemical compositions, which causes difficulty in batch production.
33559657	5	41	theme	aqueous	706:712	arg1	solution					714:721	the Alg-DA aqueous solution	695:721	the Alg-DA aqueous solution	695:721	Then an injectable hydrogel is facilely prepared by mixing strontium ions with the Alg-DA aqueous solution, utilizing the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA.
33559657	0	42	with	scaffold	18:25	arg1	activity					73:80	osteogenic activity	62:80	osteogenic activity	62:80	A simple hydrogel scaffold with injectability, adhesivity and osteogenic activity for bone regeneration.
33559657	0	42	with	scaffold	18:25	arg1	injectability					32:44	injectability	32:44	injectability	32:44	A simple hydrogel scaffold with injectability, adhesivity and osteogenic activity for bone regeneration.
33559657	0	42	with	scaffold	18:25	arg1	adhesivity					47:56	adhesivity	47:56	adhesivity	47:56	A simple hydrogel scaffold with injectability, adhesivity and osteogenic activity for bone regeneration.
33559657	1	43	theme	bone	217:220	arg1	regeneration					222:233	bone regeneration	217:233	bone regeneration	217:233	Numerous efforts have been made to prepare hydrogels with injectability, adhesivity and osteogenic activity for bone regeneration.
33559657	8	44	theme	strontium	1091:1099	arg1	ions					1101:1104	the strontium ions	1087:1104	the strontium ions	1087:1104	More importantly, the strontium ions endow the hydrogel with osteogenic activity.
33559657	6	45	theme	oxidation	836:844	arg1	conditions					846:855	the simulated oxidation conditions	822:855	the simulated oxidation conditions in vivo	822:863	Under the simulated oxidation conditions in vivo, the injectable hydrogel can form stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA.
33559657	2	46	from	difficulty	396:405	arg1	production					416:425	batch production	410:425	batch production	410:425	However, current hydrogels with these characteristics have limited application in clinical translation due to their complex chemical compositions, which causes difficulty in batch production.
33559657	2	47	theme	chemical	360:367	arg1	compositions					369:380	their complex chemical compositions	346:380	their complex chemical compositions	346:380	However, current hydrogels with these characteristics have limited application in clinical translation due to their complex chemical compositions, which causes difficulty in batch production.
33559657	7	48	theme	significant	1038:1048	arg1	adhesivity					1057:1066	significant tissue adhesivity	1038:1066	significant tissue adhesivity	1038:1066	In addition, the catechol groups endow the hydrogel with significant tissue adhesivity.
33559657	6	49	theme	simulated	826:834	arg1	conditions					846:855	the simulated oxidation conditions	822:855	the simulated oxidation conditions in vivo	822:863	Under the simulated oxidation conditions in vivo, the injectable hydrogel can form stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA.
33559657	2	50	theme	complex	352:358	arg1	compositions					369:380	their complex chemical compositions	346:380	their complex chemical compositions	346:380	However, current hydrogels with these characteristics have limited application in clinical translation due to their complex chemical compositions, which causes difficulty in batch production.
33559657	6	51	dep	in	857:858	arg1	vivo					860:863	vivo	860:863	vivo	860:863	Under the simulated oxidation conditions in vivo, the injectable hydrogel can form stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA.
33559657	5	52	theme	strontium	675:683	arg1	ions					685:688	strontium ions	675:688	strontium ions	675:688	Then an injectable hydrogel is facilely prepared by mixing strontium ions with the Alg-DA aqueous solution, utilizing the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA.
33559657	9	53	theme	bone	1249:1252	arg1	defects					1254:1260	rat bone defects	1245:1260	rat bone defects within 8 weeks	1245:1275	As indicated by animal experiments, the strontium containing hydrogel scaffolds help to treat rat bone defects within 8 weeks compared to hydrogels without strontium and control groups.
33559657	10	54	theme	binary	1381:1386	arg1	component					1388:1396	a binary component	1379:1396	a binary component	1379:1396	This simple hydrogel constructed by using a binary component has achieved several necessary functions, and is expected to be used as a scaffold for bone tissue engineering in clinical applications.
33559657	3	55	with	hydrogel	461:468	arg1	component					484:492	a binary component	475:492	a binary component	475:492	In this study, a multifunctional hydrogel with a binary component is prepared for bone regeneration.
33559657	5	56	theme	Alg-DA	808:813	arg1	ions					780:783	the strontium ions	766:783	the strontium ions	766:783	Then an injectable hydrogel is facilely prepared by mixing strontium ions with the Alg-DA aqueous solution, utilizing the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA.
33559657	5	56	theme	Alg-DA	808:813	arg1	groups					798:803	carboxyl groups	789:803	carboxyl groups of Alg-DA	789:813	Then an injectable hydrogel is facilely prepared by mixing strontium ions with the Alg-DA aqueous solution, utilizing the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA.
33559657	5	56	theme	Alg-DA	808:813	arg1	Alg-DA					808:813	Alg-DA	808:813	Alg-DA	808:813	Then an injectable hydrogel is facilely prepared by mixing strontium ions with the Alg-DA aqueous solution, utilizing the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA.
33559657	10	57	theme	tissue	1490:1495	arg1	engineering					1497:1507	bone tissue engineering	1485:1507	bone tissue engineering in clinical applications	1485:1532	This simple hydrogel constructed by using a binary component has achieved several necessary functions, and is expected to be used as a scaffold for bone tissue engineering in clinical applications.
33559657	2	58	from	application	303:313	arg1	translation					327:337	clinical translation	318:337	clinical translation	318:337	However, current hydrogels with these characteristics have limited application in clinical translation due to their complex chemical compositions, which causes difficulty in batch production.
33559657	0	59	theme	osteogenic	62:71	arg1	activity					73:80	osteogenic activity	62:80	osteogenic activity	62:80	A simple hydrogel scaffold with injectability, adhesivity and osteogenic activity for bone regeneration.
33559657	1	60	theme	osteogenic	193:202	arg1	activity					204:211	osteogenic activity	193:211	osteogenic activity	193:211	Numerous efforts have been made to prepare hydrogels with injectability, adhesivity and osteogenic activity for bone regeneration.
33559657	5	61	theme	ionic	746:750	arg1	bonds					752:756	the dynamic ionic bonds	734:756	the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA	734:813	Then an injectable hydrogel is facilely prepared by mixing strontium ions with the Alg-DA aqueous solution, utilizing the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA.
33559657	6	62	theme	chemical	906:913	arg1	crosslinkages					915:927	stable chemical crosslinkages	899:927	stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA	899:978	Under the simulated oxidation conditions in vivo, the injectable hydrogel can form stable chemical crosslinkages owing to the presence of catechol groups on Alg-DA.
33559657	2	63	theme	current	245:251	arg1	hydrogels					253:261	current hydrogels	245:261	current hydrogels with these characteristics	245:288	However, current hydrogels with these characteristics have limited application in clinical translation due to their complex chemical compositions, which causes difficulty in batch production.
33559657	5	64	theme	carboxyl	789:796	arg1	groups					798:803	carboxyl groups	789:803	carboxyl groups of Alg-DA	789:813	Then an injectable hydrogel is facilely prepared by mixing strontium ions with the Alg-DA aqueous solution, utilizing the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA.
33559657	5	64	theme	carboxyl	789:796	arg1	Alg-DA					808:813	Alg-DA	808:813	Alg-DA	808:813	Then an injectable hydrogel is facilely prepared by mixing strontium ions with the Alg-DA aqueous solution, utilizing the dynamic ionic bonds between the strontium ions and carboxyl groups of Alg-DA.
34667585	4	0	theme	LPS	688:690	arg1	intermediates					705:717	polymeric LPS biosynthetic intermediates	678:717	polymeric LPS biosynthetic intermediates	678:717	For example, the molecular interactions between polymeric LPS biosynthetic intermediates and the proteins that transfer them across the inner and outer membrane remain largely unknown.
34667585	5	1	link	lipid-linked	848:859	arg1	polysaccharides					861:875	two lipid-linked polysaccharides	844:875	two lipid-linked polysaccharides	844:875	We describe the synthesis of two lipid-linked polysaccharides, containing 11 and 27 monosaccharide residues, that are related to LPS O-chain biosynthesis in Escherichia coli O9a.
34667585	1	2	theme	immunomodulatory	177:192	arg1	lipopolysaccharide					145:162	lipopolysaccharide	145:162	lipopolysaccharide (LPS)	145:168	The biosynthesis of lipopolysaccharide (LPS), a key immunomodulatory molecule produced by gram-negative bacteria, has been a topic of long-term interest.
34667585	1	2	theme	immunomodulatory	177:192	arg1	molecule					194:201	a key immunomodulatory molecule	171:201	a key immunomodulatory molecule produced by gram-negative bacteria	171:236	The biosynthesis of lipopolysaccharide (LPS), a key immunomodulatory molecule produced by gram-negative bacteria, has been a topic of long-term interest.
34667585	3	3	theme	significant	505:515	arg1	insight					517:523	significant insight	505:523	significant insight into many aspects of LPS assembly	505:557	While such compounds have helped to provide significant insight into many aspects of LPS assembly, understanding other aspects will require larger, more complex probes.
34667585	5	4	theme	monosaccharide	899:912	arg1	residues					914:921	11 and 27 monosaccharide residues	889:921	11 and 27 monosaccharide residues	889:921	We describe the synthesis of two lipid-linked polysaccharides, containing 11 and 27 monosaccharide residues, that are related to LPS O-chain biosynthesis in Escherichia coli O9a.
34667585	4	5	theme	molecular	647:655	arg1	interactions					657:668	the molecular interactions	643:668	the molecular interactions between polymeric LPS biosynthetic intermediates and the proteins that transfer them across the inner and outer membrane	643:789	For example, the molecular interactions between polymeric LPS biosynthetic intermediates and the proteins that transfer them across the inner and outer membrane remain largely unknown.
34667585	6	6	theme	chemical	1151:1158	arg1	synthesis					1160:1168	the chemical synthesis	1147:1168	the chemical synthesis of structurally-defined polysaccharides	1147:1208	This work has led not only to multi-milligram quantities of two biosynthetic probes, but also provided insights into challenges that must be overcome in the chemical synthesis of structurally-defined polysaccharides.
34667585	4	7	theme	inner	766:770	arg1	membrane					782:789	the inner and outer membrane	762:789	membrane	782:789	For example, the molecular interactions between polymeric LPS biosynthetic intermediates and the proteins that transfer them across the inner and outer membrane remain largely unknown.
34667585	5	8	contain	containing	878:887	arg1	polysaccharides					861:875	two lipid-linked polysaccharides	844:875	two lipid-linked polysaccharides	844:875	We describe the synthesis of two lipid-linked polysaccharides, containing 11 and 27 monosaccharide residues, that are related to LPS O-chain biosynthesis in Escherichia coli O9a.
34667585	5	8	contain	containing	878:887	arg2	residues					914:921	11 and 27 monosaccharide residues	889:921	11 and 27 monosaccharide residues	889:921	We describe the synthesis of two lipid-linked polysaccharides, containing 11 and 27 monosaccharide residues, that are related to LPS O-chain biosynthesis in Escherichia coli O9a.
34667585	3	9	theme	LPS	546:548	arg1	assembly					550:557	LPS assembly	546:557	LPS assembly	546:557	While such compounds have helped to provide significant insight into many aspects of LPS assembly, understanding other aspects will require larger, more complex probes.
34667585	4	10	theme	biosynthetic	692:703	arg1	intermediates					705:717	polymeric LPS biosynthetic intermediates	678:717	polymeric LPS biosynthetic intermediates	678:717	For example, the molecular interactions between polymeric LPS biosynthetic intermediates and the proteins that transfer them across the inner and outer membrane remain largely unknown.
34667585	5	11	theme	O-chain	948:954	arg1	biosynthesis					956:967	LPS O-chain biosynthesis	944:967	LPS O-chain biosynthesis in Escherichia coli O9a	944:991	We describe the synthesis of two lipid-linked polysaccharides, containing 11 and 27 monosaccharide residues, that are related to LPS O-chain biosynthesis in Escherichia coli O9a.
34667585	2	12	theme	chemical	292:299	arg1	probes					301:306	the chemical probes	288:306	the chemical probes used as tools to study LPS biosynthetic pathways	288:355	To date, the chemical probes used as tools to study LPS biosynthetic pathways have consisted primarily of small fragments of the larger structure (e.g., the O-chain repeating unit).
34667585	2	13	theme	larger	408:413	arg1	structure					415:423	the larger structure	404:423	the larger structure (e.g., the O-chain repeating unit)	404:458	To date, the chemical probes used as tools to study LPS biosynthetic pathways have consisted primarily of small fragments of the larger structure (e.g., the O-chain repeating unit).
34667585	4	14	theme	outer	776:780	arg1	membrane					782:789	the inner and outer membrane	762:789	membrane	782:789	For example, the molecular interactions between polymeric LPS biosynthetic intermediates and the proteins that transfer them across the inner and outer membrane remain largely unknown.
34667585	2	15	dep	unit	454:457	arg1	e.g.					426:429	e.g.	426:429	e.g.	426:429	To date, the chemical probes used as tools to study LPS biosynthetic pathways have consisted primarily of small fragments of the larger structure (e.g., the O-chain repeating unit).
34667585	5	16	theme	LPS	944:946	arg1	biosynthesis					956:967	LPS O-chain biosynthesis	944:967	LPS O-chain biosynthesis in Escherichia coli O9a	944:991	We describe the synthesis of two lipid-linked polysaccharides, containing 11 and 27 monosaccharide residues, that are related to LPS O-chain biosynthesis in Escherichia coli O9a.
34667585	1	17	theme	gram-negative	215:227	arg1	bacteria					229:236	gram-negative bacteria	215:236	gram-negative bacteria	215:236	The biosynthesis of lipopolysaccharide (LPS), a key immunomodulatory molecule produced by gram-negative bacteria, has been a topic of long-term interest.
34667585	2	18	theme	repeating	444:452	arg1	unit					454:457	the O-chain repeating unit	432:457	the O-chain repeating unit	432:457	To date, the chemical probes used as tools to study LPS biosynthetic pathways have consisted primarily of small fragments of the larger structure (e.g., the O-chain repeating unit).
34667585	3	19	theme	other	574:578	arg1	aspects					580:586	other aspects	574:586	other aspects	574:586	While such compounds have helped to provide significant insight into many aspects of LPS assembly, understanding other aspects will require larger, more complex probes.
34667585	3	20	dep	larger	601:606	arg1	complex					614:620	complex	614:620	complex	614:620	While such compounds have helped to provide significant insight into many aspects of LPS assembly, understanding other aspects will require larger, more complex probes.
34667585	0	21	theme	polymeric	34:42	arg1	phosphoprenols					57:70	structurally-defined polymeric glycosylated phosphoprenols	13:70	structurally-defined polymeric glycosylated phosphoprenols	13:70	Synthesis of structurally-defined polymeric glycosylated phosphoprenols as potential lipopolysaccharide biosynthetic probes.
34667585	3	22	theme	assembly	550:557	arg1	aspects					535:541	many aspects	530:541	many aspects of LPS assembly	530:557	While such compounds have helped to provide significant insight into many aspects of LPS assembly, understanding other aspects will require larger, more complex probes.
34667585	6	23	theme	biosynthetic	1058:1069	arg1	probes					1071:1076	two biosynthetic probes	1054:1076	two biosynthetic probes	1054:1076	This work has led not only to multi-milligram quantities of two biosynthetic probes, but also provided insights into challenges that must be overcome in the chemical synthesis of structurally-defined polysaccharides.
34667585	0	24	theme	structurally-defined	13:32	arg1	phosphoprenols					57:70	structurally-defined polymeric glycosylated phosphoprenols	13:70	structurally-defined polymeric glycosylated phosphoprenols	13:70	Synthesis of structurally-defined polymeric glycosylated phosphoprenols as potential lipopolysaccharide biosynthetic probes.
34667585	6	25	dep	quantities	1040:1049	arg1	only					1016:1019	only	1016:1019	only	1016:1019	This work has led not only to multi-milligram quantities of two biosynthetic probes, but also provided insights into challenges that must be overcome in the chemical synthesis of structurally-defined polysaccharides.
34667585	3	26	theme	many	530:533	arg1	aspects					535:541	many aspects	530:541	many aspects of LPS assembly	530:557	While such compounds have helped to provide significant insight into many aspects of LPS assembly, understanding other aspects will require larger, more complex probes.
34667585	1	27	theme	lipopolysaccharide	145:162	arg1	biosynthesis					129:140	The biosynthesis	125:140	The biosynthesis of lipopolysaccharide (LPS), a key immunomodulatory molecule produced by gram-negative bacteria,	125:237	The biosynthesis of lipopolysaccharide (LPS), a key immunomodulatory molecule produced by gram-negative bacteria, has been a topic of long-term interest.
34667585	1	27	theme	lipopolysaccharide	145:162	arg1	topic					250:254	a topic	248:254	a topic of long-term interest	248:276	The biosynthesis of lipopolysaccharide (LPS), a key immunomodulatory molecule produced by gram-negative bacteria, has been a topic of long-term interest.
34667585	3	28	theme	such	467:470	arg1	compounds					472:480	such compounds	467:480	such compounds	467:480	While such compounds have helped to provide significant insight into many aspects of LPS assembly, understanding other aspects will require larger, more complex probes.
34667585	0	29	theme	phosphoprenols	57:70	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of structurally-defined polymeric glycosylated phosphoprenols as potential lipopolysaccharide biosynthetic probes.	0:123	Synthesis of structurally-defined polymeric glycosylated phosphoprenols as potential lipopolysaccharide biosynthetic probes.
34667585	0	30	dep	potential	75:83	arg1	biosynthetic					104:115	biosynthetic	104:115	biosynthetic	104:115	Synthesis of structurally-defined polymeric glycosylated phosphoprenols as potential lipopolysaccharide biosynthetic probes.
34667585	6	31	theme	probes	1071:1076	arg1	quantities					1040:1049	multi-milligram quantities	1024:1049	multi-milligram quantities of two biosynthetic probes	1024:1076	This work has led not only to multi-milligram quantities of two biosynthetic probes, but also provided insights into challenges that must be overcome in the chemical synthesis of structurally-defined polysaccharides.
34667585	5	32	theme	lipid-linked	848:859	arg1	polysaccharides					861:875	two lipid-linked polysaccharides	844:875	two lipid-linked polysaccharides	844:875	We describe the synthesis of two lipid-linked polysaccharides, containing 11 and 27 monosaccharide residues, that are related to LPS O-chain biosynthesis in Escherichia coli O9a.
34667585	0	33	theme	glycosylated	44:55	arg1	phosphoprenols					57:70	structurally-defined polymeric glycosylated phosphoprenols	13:70	structurally-defined polymeric glycosylated phosphoprenols	13:70	Synthesis of structurally-defined polymeric glycosylated phosphoprenols as potential lipopolysaccharide biosynthetic probes.
34667585	2	34	theme	O-chain	436:442	arg1	unit					454:457	the O-chain repeating unit	432:457	the O-chain repeating unit	432:457	To date, the chemical probes used as tools to study LPS biosynthetic pathways have consisted primarily of small fragments of the larger structure (e.g., the O-chain repeating unit).
34667585	2	35	theme	structure	415:423	arg1	fragments					391:399	small fragments	385:399	small fragments of the larger structure (e.g., the O-chain repeating unit)	385:458	To date, the chemical probes used as tools to study LPS biosynthetic pathways have consisted primarily of small fragments of the larger structure (e.g., the O-chain repeating unit).
34667585	0	36	theme	potential	75:83	arg1	probes					117:122	potential lipopolysaccharide biosynthetic probes	75:122	potential lipopolysaccharide biosynthetic probes	75:122	Synthesis of structurally-defined polymeric glycosylated phosphoprenols as potential lipopolysaccharide biosynthetic probes.
34667585	5	37	theme	coli	984:987	arg1	O9a					989:991	Escherichia coli O9a	972:991	Escherichia coli O9a	972:991	We describe the synthesis of two lipid-linked polysaccharides, containing 11 and 27 monosaccharide residues, that are related to LPS O-chain biosynthesis in Escherichia coli O9a.
34667585	2	38	dep	tools	316:320	arg1	study					325:329	study	325:329	to study LPS biosynthetic pathways	322:355	To date, the chemical probes used as tools to study LPS biosynthetic pathways have consisted primarily of small fragments of the larger structure (e.g., the O-chain repeating unit).
34667585	6	39	theme	polysaccharides	1194:1208	arg1	synthesis					1160:1168	the chemical synthesis	1147:1168	the chemical synthesis of structurally-defined polysaccharides	1147:1208	This work has led not only to multi-milligram quantities of two biosynthetic probes, but also provided insights into challenges that must be overcome in the chemical synthesis of structurally-defined polysaccharides.
34667585	5	40	from	biosynthesis	956:967	arg1	O9a					989:991	Escherichia coli O9a	972:991	Escherichia coli O9a	972:991	We describe the synthesis of two lipid-linked polysaccharides, containing 11 and 27 monosaccharide residues, that are related to LPS O-chain biosynthesis in Escherichia coli O9a.
34667585	0	41	gly	glycosylated	44:55	arg1	phosphoprenols					57:70	structurally-defined polymeric glycosylated phosphoprenols	13:70	structurally-defined polymeric glycosylated phosphoprenols	13:70	Synthesis of structurally-defined polymeric glycosylated phosphoprenols as potential lipopolysaccharide biosynthetic probes.
34667585	3	42	theme	larger	601:606	arg1	probes					622:627	larger, more complex probes	601:627	larger, more complex probes	601:627	While such compounds have helped to provide significant insight into many aspects of LPS assembly, understanding other aspects will require larger, more complex probes.
34667585	2	43	theme	biosynthetic	335:346	arg1	pathways					348:355	LPS biosynthetic pathways	331:355	LPS biosynthetic pathways	331:355	To date, the chemical probes used as tools to study LPS biosynthetic pathways have consisted primarily of small fragments of the larger structure (e.g., the O-chain repeating unit).
34667585	6	44	theme	multi-milligram	1024:1038	arg1	quantities					1040:1049	multi-milligram quantities	1024:1049	multi-milligram quantities of two biosynthetic probes	1024:1076	This work has led not only to multi-milligram quantities of two biosynthetic probes, but also provided insights into challenges that must be overcome in the chemical synthesis of structurally-defined polysaccharides.
34667585	5	45	theme	Escherichia	972:982	arg1	O9a					989:991	Escherichia coli O9a	972:991	Escherichia coli O9a	972:991	We describe the synthesis of two lipid-linked polysaccharides, containing 11 and 27 monosaccharide residues, that are related to LPS O-chain biosynthesis in Escherichia coli O9a.
34667585	4	46	theme	polymeric	678:686	arg1	intermediates					705:717	polymeric LPS biosynthetic intermediates	678:717	polymeric LPS biosynthetic intermediates	678:717	For example, the molecular interactions between polymeric LPS biosynthetic intermediates and the proteins that transfer them across the inner and outer membrane remain largely unknown.
34667585	5	47	theme	polysaccharides	861:875	arg1	synthesis					831:839	the synthesis	827:839	the synthesis of two lipid-linked polysaccharides, containing 11 and 27 monosaccharide residues, that are related to LPS O-chain biosynthesis in Escherichia coli O9a	827:991	We describe the synthesis of two lipid-linked polysaccharides, containing 11 and 27 monosaccharide residues, that are related to LPS O-chain biosynthesis in Escherichia coli O9a.
34667585	2	48	theme	small	385:389	arg1	fragments					391:399	small fragments	385:399	small fragments of the larger structure (e.g., the O-chain repeating unit)	385:458	To date, the chemical probes used as tools to study LPS biosynthetic pathways have consisted primarily of small fragments of the larger structure (e.g., the O-chain repeating unit).
34667585	6	49	theme	structurally-defined	1173:1192	arg1	polysaccharides					1194:1208	structurally-defined polysaccharides	1173:1208	structurally-defined polysaccharides	1173:1208	This work has led not only to multi-milligram quantities of two biosynthetic probes, but also provided insights into challenges that must be overcome in the chemical synthesis of structurally-defined polysaccharides.
34667585	1	50	theme	long-term	259:267	arg1	interest					269:276	long-term interest	259:276	long-term interest	259:276	The biosynthesis of lipopolysaccharide (LPS), a key immunomodulatory molecule produced by gram-negative bacteria, has been a topic of long-term interest.
34667585	1	51	theme	key	173:175	arg1	lipopolysaccharide					145:162	lipopolysaccharide	145:162	lipopolysaccharide (LPS)	145:168	The biosynthesis of lipopolysaccharide (LPS), a key immunomodulatory molecule produced by gram-negative bacteria, has been a topic of long-term interest.
34667585	1	51	theme	key	173:175	arg1	molecule					194:201	a key immunomodulatory molecule	171:201	a key immunomodulatory molecule produced by gram-negative bacteria	171:236	The biosynthesis of lipopolysaccharide (LPS), a key immunomodulatory molecule produced by gram-negative bacteria, has been a topic of long-term interest.
34667585	1	52	theme	interest	269:276	arg1	biosynthesis					129:140	The biosynthesis	125:140	The biosynthesis of lipopolysaccharide (LPS), a key immunomodulatory molecule produced by gram-negative bacteria,	125:237	The biosynthesis of lipopolysaccharide (LPS), a key immunomodulatory molecule produced by gram-negative bacteria, has been a topic of long-term interest.
34667585	1	52	theme	interest	269:276	arg1	topic					250:254	a topic	248:254	a topic of long-term interest	248:276	The biosynthesis of lipopolysaccharide (LPS), a key immunomodulatory molecule produced by gram-negative bacteria, has been a topic of long-term interest.
34237946	4	0	dep	responses	979:987	arg1	Carrs index					1004:1014	Carrs index	1004:1014	Carrs index	1004:1014	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	4	0	dep	responses	979:987	arg1	responses					979:987	responses	979:987	responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time	979:1084	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	4	0	dep	responses	979:987	arg1	friability					1017:1026	friability	1017:1026	friability	1017:1026	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	4	0	dep	responses	979:987	arg1	density					995:1001	bulk density	990:1001	bulk density	990:1001	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	4	0	dep	responses	979:987	arg1	resistance					1029:1038	resistance	1029:1038	resistance to crushing	1029:1050	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	4	0	dep	responses	979:987	arg1	time					1081:1084	in vitro disintegration time	1057:1084	in vitro disintegration time	1057:1084	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	2	1	theme	pharmaco-technical	363:380	arg1	properties					382:391	the sufficient pharmaco-technical properties	348:391	the sufficient pharmaco-technical properties of the tablet blend	348:411	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	5	2	theme	several	1211:1217	arg1	effects					1231:1237	several interaction effects	1211:1237	several interaction effects	1211:1237	ANOVA approach was applied for statistical processing, which allowed to reveal the individual effects of each excipient and several interaction effects observed for the excipient amounts used in this study.
34237946	1	3	theme	magnesium	237:245	arg1	citrate					247:253	magnesium citrate	237:253	magnesium citrate obtained by the direct compression method	237:295	The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method.
34237946	0	4	theme	cube	94:97	arg1	design					99:104	a fractional factorial Latin cube design	65:104	a fractional factorial Latin cube design	65:104	Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach.
34237946	3	5	theme	guar	826:829	arg1	gum					831:833	guar gum	826:833	guar gum (gel-forming binders)	826:855	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	5	theme	guar	826:829	arg1	binders					848:854	gel-forming binders	836:854	gel-forming binders	836:854	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	2	6	theme	sufficient	352:361	arg1	properties					382:391	the sufficient pharmaco-technical properties	348:391	the sufficient pharmaco-technical properties of the tablet blend	348:411	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	5	7	theme	interaction	1219:1229	arg1	effects					1231:1237	several interaction effects	1211:1237	several interaction effects	1211:1237	ANOVA approach was applied for statistical processing, which allowed to reveal the individual effects of each excipient and several interaction effects observed for the excipient amounts used in this study.
34237946	1	8	theme	citrate	247:253	arg1	mg					231:232	250 mg	227:232	250 mg of magnesium citrate obtained by the direct compression method	227:295	The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method.
34237946	1	8	theme	citrate	247:253	arg1	mg					209:210	100 mg	205:210	100 mg of glycine	205:221	The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method.
34237946	0	9	theme	ANOVA	110:114	arg1	approach					116:123	ANOVA approach	110:123	ANOVA approach	110:123	Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach.
34237946	3	10	theme	Metolose®	800:808	arg1	90SH-4000SR					810:820	Metolose® 90SH-4000SR	800:820	Metolose® 90SH-4000SR	800:820	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	5	11	theme	individual	1170:1179	arg1	effects					1181:1187	the individual effects	1166:1187	the individual effects of each excipient	1166:1205	ANOVA approach was applied for statistical processing, which allowed to reveal the individual effects of each excipient and several interaction effects observed for the excipient amounts used in this study.
34237946	3	12	dep	Avicel®	770:776	arg1	binders					790:796	dry binders	786:796	Avicel® PH-101 (dry binders)	770:797	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	2	13	dep	non-disintegrating	449:466	arg1	slow-dissolving					469:483	slow-dissolving	469:483	slow-dissolving	469:483	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	6	14	theme	lozenges	1464:1471	arg1	formulation					1438:1448	the final formulation	1428:1448	the final formulation of compressed lozenges	1428:1471	Isomalt (GalenIQ 721), copovidone (Plasdone S-630), and glyceryl behenate (Compritol® 888 CG ATO) were selected to be incorporated in the final formulation of compressed lozenges.
34237946	1	15	theme	anti-stress	162:172	arg1	lozenges					185:192	anti-stress compressed lozenges	162:192	anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method	162:295	The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method.
34237946	2	16	theme	experimental	536:547	arg1	formulations					549:560	27 experimental formulations	533:560	27 experimental formulations according to fractional factorial Latin cube design	533:612	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	2	17	theme	lozenges	508:515	arg1	composition					326:336	optimal excipient composition	308:336	optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges	308:515	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	6	18	theme	glyceryl	1350:1357	arg1	behenate					1359:1366	glyceryl behenate	1350:1366	glyceryl behenate (Compritol® 888 CG ATO)	1350:1390	Isomalt (GalenIQ 721), copovidone (Plasdone S-630), and glyceryl behenate (Compritol® 888 CG ATO) were selected to be incorporated in the final formulation of compressed lozenges.
34237946	1	19	theme	compressed	174:183	arg1	lozenges					185:192	anti-stress compressed lozenges	162:192	anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method	162:295	The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method.
34237946	2	20	theme	compressed	497:506	arg1	lozenges					508:515	compressed lozenges	497:515	compressed lozenges	497:515	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	4	21	theme	following	937:945	arg1	responses					979:987	responses	979:987	responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time	979:1084	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	4	21	theme	following	937:945	arg1	parameters					947:956	The following parameters	933:956	The following parameters	933:956	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	2	22	theme	optimal	308:314	arg1	composition					326:336	optimal excipient composition	308:336	optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges	308:515	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	2	23	theme	tablet	400:405	arg1	blend					407:411	the tablet blend	396:411	the tablet blend	396:411	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	0	24	theme	Formulation	0:10	arg1	development					12:22	Formulation development	0:22	Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach.	0:124	Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach.
34237946	4	25	theme	in	1057:1058	arg1	responses					979:987	responses	979:987	responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time	979:1084	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	4	25	theme	in	1057:1058	arg1	time					1081:1084	in vitro disintegration time	1057:1084	in vitro disintegration time	1057:1084	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	0	26	theme	anti-stress	27:37	arg1	lozenges					50:57	anti-stress compressed lozenges	27:57	anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach	27:123	Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach.
34237946	1	27	theme	direct	271:276	arg1	method					290:295	the direct compression method	267:295	the direct compression method	267:295	The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method.
34237946	2	28	theme	cube	602:605	arg1	design					607:612	fractional factorial Latin cube design	575:612	fractional factorial Latin cube design	575:612	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	6	29	theme	final	1432:1436	arg1	formulation					1438:1448	the final formulation	1428:1448	the final formulation of compressed lozenges	1428:1471	Isomalt (GalenIQ 721), copovidone (Plasdone S-630), and glyceryl behenate (Compritol® 888 CG ATO) were selected to be incorporated in the final formulation of compressed lozenges.
34237946	2	30	theme	tablets	437:443	arg1	strength					425:432	mechanical strength	414:432	mechanical strength of tablets	414:443	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	2	30	theme	tablets	437:443	arg1	properties					382:391	the sufficient pharmaco-technical properties	348:391	the sufficient pharmaco-technical properties of the tablet blend	348:411	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	2	30	theme	tablets	437:443	arg1	behavior					485:492	non-disintegrating, slow-dissolving behavior	449:492	non-disintegrating, slow-dissolving behavior	449:492	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	1	31	theme	compression	278:288	arg1	method					290:295	the direct compression method	267:295	the direct compression method	267:295	The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method.
34237946	2	32	theme	Latin	596:600	arg1	design					607:612	fractional factorial Latin cube design	575:612	fractional factorial Latin cube design	575:612	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	1	33	contain	containing	194:203	arg1	lozenges					185:192	anti-stress compressed lozenges	162:192	anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method	162:295	The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method.
34237946	1	33	contain	containing	194:203	arg2	mg					209:210	100 mg	205:210	100 mg of glycine	205:221	The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method.
34237946	1	33	contain	containing	194:203	arg2	mg					231:232	250 mg	227:232	250 mg of magnesium citrate obtained by the direct compression method	227:295	The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method.
34237946	4	34	theme	disintegration	1066:1079	arg1	responses					979:987	responses	979:987	responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time	979:1084	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	4	34	theme	disintegration	1066:1079	arg1	time					1081:1084	in vitro disintegration time	1057:1084	in vitro disintegration time	1057:1084	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	0	35	theme	lozenges	50:57	arg1	development					12:22	Formulation development	0:22	Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach.	0:124	Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach.
34237946	3	36	theme	Kollidon®	751:759	arg1	F					764:764	Kollidon® 90 F	751:764	Kollidon® 90 F	751:764	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	2	37	theme	factorial	586:594	arg1	design					607:612	fractional factorial Latin cube design	575:612	fractional factorial Latin cube design	575:612	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	5	38	theme	excipient	1256:1264	arg1	amounts					1266:1272	the excipient amounts	1252:1272	the excipient amounts used in this study	1252:1291	ANOVA approach was applied for statistical processing, which allowed to reveal the individual effects of each excipient and several interaction effects observed for the excipient amounts used in this study.
34237946	0	39	theme	compressed	39:48	arg1	lozenges					50:57	anti-stress compressed lozenges	27:57	anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach	27:123	Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach.
34237946	2	40	theme	fractional	575:584	arg1	design					607:612	fractional factorial Latin cube design	575:612	fractional factorial Latin cube design	575:612	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	2	41	theme	non-disintegrating	449:466	arg1	behavior					485:492	non-disintegrating, slow-dissolving behavior	449:492	non-disintegrating, slow-dissolving behavior	449:492	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	3	42	dep	Neusilin®	865:873	arg1	US2					875:877	US2	875:877	US2	875:877	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	1	43	theme	glycine	215:221	arg1	mg					231:232	250 mg	227:232	250 mg of magnesium citrate obtained by the direct compression method	227:295	The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method.
34237946	1	43	theme	glycine	215:221	arg1	mg					209:210	100 mg	205:210	100 mg of glycine	205:221	The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method.
34237946	0	44	theme	a fractional	65:76	arg1	design					99:104	a fractional factorial Latin cube design	65:104	a fractional factorial Latin cube design	65:104	Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach.
34237946	6	45	theme	Plasdone	1329:1336	arg1	copovidone					1317:1326	copovidone	1317:1326	copovidone (Plasdone S-630)	1317:1343	Isomalt (GalenIQ 721), copovidone (Plasdone S-630), and glyceryl behenate (Compritol® 888 CG ATO) were selected to be incorporated in the final formulation of compressed lozenges.
34237946	6	45	theme	Plasdone	1329:1336	arg1	S-630					1338:1342	Plasdone S-630	1329:1342	Plasdone S-630	1329:1342	Isomalt (GalenIQ 721), copovidone (Plasdone S-630), and glyceryl behenate (Compritol® 888 CG ATO) were selected to be incorporated in the final formulation of compressed lozenges.
34237946	5	46	theme	ANOVA	1087:1091	arg1	approach					1093:1100	ANOVA approach	1087:1100	ANOVA approach	1087:1100	ANOVA approach was applied for statistical processing, which allowed to reveal the individual effects of each excipient and several interaction effects observed for the excipient amounts used in this study.
34237946	6	47	dep	behenate	1359:1366	arg1	Compritol®					1369:1378	Compritol®	1369:1378	Compritol®	1369:1378	Isomalt (GalenIQ 721), copovidone (Plasdone S-630), and glyceryl behenate (Compritol® 888 CG ATO) were selected to be incorporated in the final formulation of compressed lozenges.
34237946	4	48	dep	in	1057:1058	arg1	vitro					1060:1064	vitro	1060:1064	vitro	1060:1064	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	3	49	theme	gel-forming	836:846	arg1	gum					831:833	guar gum	826:833	guar gum (gel-forming binders)	826:855	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	49	theme	gel-forming	836:846	arg1	binders					848:854	gel-forming binders	836:854	gel-forming binders	836:854	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	5	50	theme	statistical	1118:1128	arg1	processing					1130:1139	statistical processing	1118:1139	statistical processing	1118:1139	ANOVA approach was applied for statistical processing, which allowed to reveal the individual effects of each excipient and several interaction effects observed for the excipient amounts used in this study.
34237946	3	51	theme	antifriction	907:918	arg1	excipients					920:929	antifriction excipients	907:929	antifriction excipients	907:929	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	51	theme	antifriction	907:918	arg1	ATO					902:904	ATO	902:904	ATO	902:904	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	52	dep	were	673:676	arg1	gum					831:833	guar gum	826:833	guar gum (gel-forming binders)	826:855	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	52	dep	were	673:676	arg1	binders					848:854	gel-forming binders	836:854	gel-forming binders	836:854	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	52	dep	were	673:676	arg1	ATO					902:904	ATO	902:904	ATO	902:904	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	52	dep	were	673:676	arg1	Avicel®					770:776	Avicel®	770:776	Avicel®	770:776	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	52	dep	were	673:676	arg1	GalenIQ					712:718	GalenIQ	712:718	GalenIQ	712:718	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	52	dep	were	673:676	arg1	EZ					689:690	EZ	689:690	EZ	689:690	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	52	dep	were	673:676	arg1	90SH-4000SR					810:820	Metolose® 90SH-4000SR	800:820	Metolose® 90SH-4000SR	800:820	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	52	dep	were	673:676	arg1	fillers					725:731	fillers	725:731	fillers	725:731	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	52	dep	were	673:676	arg1	excipients					920:929	antifriction excipients	907:929	antifriction excipients	907:929	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	52	dep	were	673:676	arg1	Cellactose®					693:703	Cellactose®	693:703	Cellactose®	693:703	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	52	dep	were	673:676	arg1	F					764:764	Kollidon® 90 F	751:764	Kollidon® 90 F	751:764	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	3	52	dep	were	673:676	arg1	Neusilin®					865:873	Neusilin®	865:873	Neusilin®	865:873	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	6	53	dep	Compritol®	1369:1378	arg1	ATO					1387:1389	ATO	1387:1389	ATO	1387:1389	Isomalt (GalenIQ 721), copovidone (Plasdone S-630), and glyceryl behenate (Compritol® 888 CG ATO) were selected to be incorporated in the final formulation of compressed lozenges.
34237946	2	54	theme	excipient	316:324	arg1	composition					326:336	optimal excipient composition	308:336	optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges	308:515	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	6	55	theme	compressed	1453:1462	arg1	lozenges					1464:1471	compressed lozenges	1453:1471	compressed lozenges	1453:1471	Isomalt (GalenIQ 721), copovidone (Plasdone S-630), and glyceryl behenate (Compritol® 888 CG ATO) were selected to be incorporated in the final formulation of compressed lozenges.
34237946	0	56	theme	Latin	88:92	arg1	design					99:104	a fractional factorial Latin cube design	65:104	a fractional factorial Latin cube design	65:104	Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach.
34237946	2	57	theme	mechanical	414:423	arg1	strength					425:432	mechanical strength	414:432	mechanical strength of tablets	414:443	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	1	58	theme	work	142:145	arg1	aim					130:132	The aim	126:132	The aim of this work	126:145	The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method.
34237946	2	59	theme	blend	407:411	arg1	strength					425:432	mechanical strength	414:432	mechanical strength of tablets	414:443	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	2	59	theme	blend	407:411	arg1	properties					382:391	the sufficient pharmaco-technical properties	348:391	the sufficient pharmaco-technical properties of the tablet blend	348:411	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	2	59	theme	blend	407:411	arg1	behavior					485:492	non-disintegrating, slow-dissolving behavior	449:492	non-disintegrating, slow-dissolving behavior	449:492	To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical strength of tablets and non-disintegrating, slow-dissolving behavior of compressed lozenges during sucking, 27 experimental formulations according to fractional factorial Latin cube design were prepared and tested.
34237946	3	60	theme	dry	786:788	arg1	binders					790:796	dry binders	786:796	Avicel® PH-101 (dry binders)	770:797	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34237946	0	61	theme	factorial	78:86	arg1	design					99:104	a fractional factorial Latin cube design	65:104	a fractional factorial Latin cube design	65:104	Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach.
34237946	5	62	theme	excipient	1197:1205	arg1	effects					1231:1237	several interaction effects	1211:1237	several interaction effects	1211:1237	ANOVA approach was applied for statistical processing, which allowed to reveal the individual effects of each excipient and several interaction effects observed for the excipient amounts used in this study.
34237946	5	62	theme	excipient	1197:1205	arg1	effects					1181:1187	the individual effects	1166:1187	the individual effects of each excipient	1166:1205	ANOVA approach was applied for statistical processing, which allowed to reveal the individual effects of each excipient and several interaction effects observed for the excipient amounts used in this study.
34237946	4	63	theme	bulk	990:993	arg1	responses					979:987	responses	979:987	responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time	979:1084	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	4	63	theme	bulk	990:993	arg1	density					995:1001	bulk density	990:1001	bulk density	990:1001	The following parameters were investigated as responses: bulk density, Carrs index, friability, resistance to crushing, and in vitro disintegration time.
34237946	3	64	dep	EZ	689:690	arg1	Plasdone					735:742	Plasdone	735:742	Plasdone	735:742	The excipients used in the study were: Mannogem® EZ, Cellactose® 80 and GalenIQ 721 (fillers); Plasdone S-630, Kollidon® 90 F and Avicel® PH-101 (dry binders); Metolose® 90SH-4000SR and guar gum (gel-forming binders); PRUV®, Neusilin® US2, and Compritol® 888 CG ATO (antifriction excipients).
34875481	6	0	theme	excellent	957:965	arg1	ability					988:994	excellent oil-water separation ability	957:994	excellent oil-water separation ability	957:994	The aerogel shows excellent oil-water separation ability and it can be repeatedly used more than 10 times.
34875481	0	1	theme	cellulose	85:93	arg1	nanocrystals					95:106	tunicate cellulose nanocrystals	76:106	tunicate cellulose nanocrystals	76:106	Preparation and characterization of super hydrophobic aerogels derived from tunicate cellulose nanocrystals.
34875481	3	2	theme	scanning	518:525	arg1	SEM					548:550	SEM	548:550	SEM	548:550	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	3	2	theme	scanning	518:525	arg1	microscope					536:545	scanning electron microscope	518:545	scanning electron microscope (SEM)	518:551	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	3	3	theme	electron	567:574	arg1	TEM					588:590	TEM	588:590	TEM	588:590	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	3	3	theme	electron	567:574	arg1	microscopy					576:585	transmission electron microscopy	554:585	transmission electron microscopy (TEM)	554:591	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	1	4	theme	animal	277:282	arg1	resources					294:302	animal cellulose resources	277:302	animal cellulose resources	277:302	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
34875481	2	5	attach	cross-linked	341:352	arg3	study					313:317	this study	308:317	this study	308:317	In this study, the TCNC was firstly cross-linked with silica and methyltrimethylsilane (MTMS), further coated with fluorodopa to form an aerogel with super hydrophobic properties.
34875481	5	6	from	immersion	854:862	arg1	solutions					881:889	pH = 0 and 12 solutions	867:889	pH = 0 and 12 solutions	867:889	The composite aerogel has superior stability in wide pH range, after 72 h immersion in pH = 0 and 12 solutions, the contact angle was still greater than 150°.
34875481	1	7	theme	cellulose	284:292	arg1	resources					294:302	animal cellulose resources	277:302	animal cellulose resources	277:302	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
34875481	8	8	theme	animal	1257:1262	arg1	celluloses					1264:1273	marine animal celluloses	1250:1273	marine animal celluloses	1250:1273	This synthesized super hydrophobic aerogels derived from tunicate cellulose has greatly extended the application of marine animal celluloses.
34875481	7	9	theme	different	1104:1112	arg1	mixtures					1124:1131	different water-oil mixtures	1104:1131	different water-oil mixtures	1104:1131	The separation efficiency can all reach more than 90% for different water-oil mixtures.
34875481	2	10	theme	super	455:459	arg1	properties					473:482	super hydrophobic properties	455:482	super hydrophobic properties	455:482	In this study, the TCNC was firstly cross-linked with silica and methyltrimethylsilane (MTMS), further coated with fluorodopa to form an aerogel with super hydrophobic properties.
34875481	7	11	theme	separation	1050:1059	arg1	efficiency					1061:1070	The separation efficiency	1046:1070	The separation efficiency	1046:1070	The separation efficiency can all reach more than 90% for different water-oil mixtures.
34875481	6	12	used	used	1021:1024	arg2	it					1000:1001	it	1000:1001	it	1000:1001	The aerogel shows excellent oil-water separation ability and it can be repeatedly used more than 10 times.
34875481	1	13	theme	tunicate	197:204	arg1	TCNC					230:233	TCNC	230:233	TCNC	230:233	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
34875481	1	13	theme	tunicate	197:204	arg1	nanocrystals					216:227	tunicate cellulose nanocrystals	197:227	tunicate cellulose nanocrystals (TCNC)	197:234	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
34875481	5	14	theme	composite	784:792	arg1	aerogel					794:800	The composite aerogel	780:800	The composite aerogel	780:800	The composite aerogel has superior stability in wide pH range, after 72 h immersion in pH = 0 and 12 solutions, the contact angle was still greater than 150°.
34875481	1	15	with	composite	129:137	arg1	properties					162:171	super hydrophobic properties	144:171	super hydrophobic properties	144:171	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
34875481	5	16	theme	contact	896:902	arg1	angle					904:908	the contact angle	892:908	the contact angle	892:908	The composite aerogel has superior stability in wide pH range, after 72 h immersion in pH = 0 and 12 solutions, the contact angle was still greater than 150°.
34875481	5	16	theme	contact	896:902	arg1	greater					920:926	greater	920:926	greater	920:926	The composite aerogel has superior stability in wide pH range, after 72 h immersion in pH = 0 and 12 solutions, the contact angle was still greater than 150°.
34875481	1	17	theme	cellulose	206:214	arg1	TCNC					230:233	TCNC	230:233	TCNC	230:233	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
34875481	1	17	theme	cellulose	206:214	arg1	nanocrystals					216:227	tunicate cellulose nanocrystals	197:227	tunicate cellulose nanocrystals (TCNC)	197:234	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
34875481	1	18	theme	resources	294:302	arg1	scope					268:272	the application scope	252:272	the application scope of animal cellulose resources	252:302	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
34875481	1	19	theme	First	109:113	arg1	aerogels					120:127	First time aerogels	109:127	First time aerogels composite with super hydrophobic properties	109:171	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
34875481	3	20	dep	Fourier	594:600	arg1	transform					602:610	transform	602:610	transform infrared spectra	602:627	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	8	21	theme	super	1151:1155	arg1	aerogels					1169:1176	super hydrophobic aerogels	1151:1176	super hydrophobic aerogels derived from tunicate cellulose has greatly extended the application of marine animal celluloses	1151:1273	This synthesized super hydrophobic aerogels derived from tunicate cellulose has greatly extended the application of marine animal celluloses.
34875481	8	22	theme	celluloses	1264:1273	arg1	application					1235:1245	the application	1231:1245	the application of marine animal celluloses	1231:1273	This synthesized super hydrophobic aerogels derived from tunicate cellulose has greatly extended the application of marine animal celluloses.
34875481	1	23	theme	time	115:118	arg1	aerogels					120:127	First time aerogels	109:127	First time aerogels composite with super hydrophobic properties	109:171	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
34875481	5	24	theme	superior	806:813	arg1	stability					815:823	superior stability	806:823	superior stability	806:823	The composite aerogel has superior stability in wide pH range, after 72 h immersion in pH = 0 and 12 solutions, the contact angle was still greater than 150°.
34875481	2	25	dep	cross-linked	341:352	arg1	coated					408:413	coated	408:413	coated with fluorodopa to form an aerogel with super hydrophobic properties	408:482	In this study, the TCNC was firstly cross-linked with silica and methyltrimethylsilane (MTMS), further coated with fluorodopa to form an aerogel with super hydrophobic properties.
34875481	0	26	theme	hydrophobic	42:52	arg1	aerogels					54:61	super hydrophobic aerogels	36:61	super hydrophobic aerogels	36:61	Preparation and characterization of super hydrophobic aerogels derived from tunicate cellulose nanocrystals.
34875481	5	27	contain	has	802:804	arg1	aerogel					794:800	The composite aerogel	780:800	The composite aerogel	780:800	The composite aerogel has superior stability in wide pH range, after 72 h immersion in pH = 0 and 12 solutions, the contact angle was still greater than 150°.
34875481	5	27	contain	has	802:804	arg2	stability					815:823	superior stability	806:823	superior stability	806:823	The composite aerogel has superior stability in wide pH range, after 72 h immersion in pH = 0 and 12 solutions, the contact angle was still greater than 150°.
34875481	5	28	theme	72 h	849:852	arg1	immersion					854:862	72 h immersion	849:862	72 h immersion in pH = 0 and 12 solutions	849:889	The composite aerogel has superior stability in wide pH range, after 72 h immersion in pH = 0 and 12 solutions, the contact angle was still greater than 150°.
34875481	5	29	theme	wide	828:831	arg1	range					836:840	wide pH range	828:840	wide pH range	828:840	The composite aerogel has superior stability in wide pH range, after 72 h immersion in pH = 0 and 12 solutions, the contact angle was still greater than 150°.
34875481	0	30	theme	super	36:40	arg1	aerogels					54:61	super hydrophobic aerogels	36:61	super hydrophobic aerogels	36:61	Preparation and characterization of super hydrophobic aerogels derived from tunicate cellulose nanocrystals.
34875481	8	31	theme	hydrophobic	1157:1167	arg1	aerogels					1169:1176	super hydrophobic aerogels	1151:1176	super hydrophobic aerogels derived from tunicate cellulose has greatly extended the application of marine animal celluloses	1151:1273	This synthesized super hydrophobic aerogels derived from tunicate cellulose has greatly extended the application of marine animal celluloses.
34875481	6	32	theme	oil-water	967:975	arg1	ability					988:994	excellent oil-water separation ability	957:994	excellent oil-water separation ability	957:994	The aerogel shows excellent oil-water separation ability and it can be repeatedly used more than 10 times.
34875481	5	33	theme	pH	833:834	arg1	range					836:840	wide pH range	828:840	wide pH range	828:840	The composite aerogel has superior stability in wide pH range, after 72 h immersion in pH = 0 and 12 solutions, the contact angle was still greater than 150°.
34875481	2	34	theme	hydrophobic	461:471	arg1	properties					473:482	super hydrophobic properties	455:482	super hydrophobic properties	455:482	In this study, the TCNC was firstly cross-linked with silica and methyltrimethylsilane (MTMS), further coated with fluorodopa to form an aerogel with super hydrophobic properties.
34875481	1	35	theme	composite	129:137	arg1	aerogels					120:127	First time aerogels	109:127	First time aerogels composite with super hydrophobic properties	109:171	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
34875481	0	36	theme	aerogels	54:61	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of super hydrophobic aerogels derived from tunicate cellulose nanocrystals.
34875481	0	36	theme	aerogels	54:61	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of super hydrophobic aerogels derived from tunicate cellulose nanocrystals.
34875481	8	37	theme	marine	1250:1255	arg1	celluloses					1264:1273	marine animal celluloses	1250:1273	marine animal celluloses	1250:1273	This synthesized super hydrophobic aerogels derived from tunicate cellulose has greatly extended the application of marine animal celluloses.
34875481	2	38	with	aerogel	442:448	arg1	properties					473:482	super hydrophobic properties	455:482	super hydrophobic properties	455:482	In this study, the TCNC was firstly cross-linked with silica and methyltrimethylsilane (MTMS), further coated with fluorodopa to form an aerogel with super hydrophobic properties.
34875481	1	39	theme	super	144:148	arg1	properties					162:171	super hydrophobic properties	144:171	super hydrophobic properties	144:171	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
34875481	3	40	theme	transmission	554:565	arg1	TEM					588:590	TEM	588:590	TEM	588:590	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	3	40	theme	transmission	554:565	arg1	microscopy					576:585	transmission electron microscopy	554:585	transmission electron microscopy (TEM)	554:591	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	3	41	theme	X-ray	642:646	arg1	XPS					676:678	XPS	676:678	XPS	676:678	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	3	41	theme	X-ray	642:646	arg1	spectroscopy					662:673	X-ray photoelectron spectroscopy	642:673	X-ray photoelectron spectroscopy (XPS)	642:679	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	4	42	theme	good	759:762	arg1	hydrophobicity					764:777	good hydrophobicity	759:777	good hydrophobicity	759:777	Results indicated that the contact angle of aerogel was 158.7°, which showed good hydrophobicity.
34875481	4	43	theme	aerogel	726:732	arg1	angle					717:721	the contact angle	705:721	the contact angle of aerogel	705:732	Results indicated that the contact angle of aerogel was 158.7°, which showed good hydrophobicity.
34875481	4	43	theme	aerogel	726:732	arg1	158.7°					738:743	158.7°	738:743	158.7°	738:743	Results indicated that the contact angle of aerogel was 158.7°, which showed good hydrophobicity.
34875481	1	44	theme	hydrophobic	150:160	arg1	properties					162:171	super hydrophobic properties	144:171	super hydrophobic properties	144:171	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
34875481	4	45	theme	contact	709:715	arg1	angle					717:721	the contact angle	705:721	the contact angle of aerogel	705:732	Results indicated that the contact angle of aerogel was 158.7°, which showed good hydrophobicity.
34875481	4	45	theme	contact	709:715	arg1	158.7°					738:743	158.7°	738:743	158.7°	738:743	Results indicated that the contact angle of aerogel was 158.7°, which showed good hydrophobicity.
34875481	0	46	theme	tunicate	76:83	arg1	nanocrystals					95:106	tunicate cellulose nanocrystals	76:106	tunicate cellulose nanocrystals	76:106	Preparation and characterization of super hydrophobic aerogels derived from tunicate cellulose nanocrystals.
34875481	3	47	theme	photoelectron	648:660	arg1	XPS					676:678	XPS	676:678	XPS	676:678	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	3	47	theme	photoelectron	648:660	arg1	spectroscopy					662:673	X-ray photoelectron spectroscopy	642:673	X-ray photoelectron spectroscopy (XPS)	642:679	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	8	48	attach	derived	1178:1184	arg2	aerogels					1169:1176	super hydrophobic aerogels	1151:1176	super hydrophobic aerogels derived from tunicate cellulose has greatly extended the application of marine animal celluloses	1151:1273	This synthesized super hydrophobic aerogels derived from tunicate cellulose has greatly extended the application of marine animal celluloses.
34875481	8	48	attach	derived	1178:1184	arg1	cellulose					1200:1208	tunicate cellulose	1191:1208	tunicate cellulose has greatly extended the application of marine animal celluloses	1191:1273	This synthesized super hydrophobic aerogels derived from tunicate cellulose has greatly extended the application of marine animal celluloses.
34875481	3	49	theme	electron	527:534	arg1	SEM					548:550	SEM	548:550	SEM	548:550	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	3	49	theme	electron	527:534	arg1	microscope					536:545	scanning electron microscope	518:545	scanning electron microscope (SEM)	518:551	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	8	50	theme	tunicate	1191:1198	arg1	cellulose					1200:1208	tunicate cellulose	1191:1208	tunicate cellulose has greatly extended the application of marine animal celluloses	1191:1273	This synthesized super hydrophobic aerogels derived from tunicate cellulose has greatly extended the application of marine animal celluloses.
34875481	6	51	theme	separation	977:986	arg1	ability					988:994	excellent oil-water separation ability	957:994	excellent oil-water separation ability	957:994	The aerogel shows excellent oil-water separation ability and it can be repeatedly used more than 10 times.
34875481	8	52	dep	cellulose	1200:1208	arg1	extended					1222:1229	extended	1222:1229	has greatly extended the application of marine animal celluloses	1210:1273	This synthesized super hydrophobic aerogels derived from tunicate cellulose has greatly extended the application of marine animal celluloses.
34875481	3	53	theme	infrared	612:619	arg1	spectra					621:627	infrared spectra	612:627	infrared spectra	612:627	The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS).
34875481	7	54	theme	water-oil	1114:1122	arg1	mixtures					1124:1131	different water-oil mixtures	1104:1131	different water-oil mixtures	1104:1131	The separation efficiency can all reach more than 90% for different water-oil mixtures.
34875481	1	55	theme	application	256:266	arg1	scope					268:272	the application scope	252:272	the application scope of animal cellulose resources	252:302	First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources.
33334243	2	0	theme	cell	432:435	arg1	proliferation					437:449	cell proliferation	432:449	cell proliferation	432:449	The aim of this study is to scrutinize different parameters of the bioprinter - with the help of simulation software - to print a hydrogel so much so that avoid high amounts of shear stress which is detrimental for cell viability and cell proliferation.
33334243	3	1	theme	Rheology	452:459	arg1	analysis					461:468	Rheology analysis	452:468	Rheology analysis	452:468	Rheology analysis was done on several hydrogels composed of different percentages of components: alginate, collagen, and gelatin.
33334243	5	2	theme	1 h.	888:891	arg1	duration					876:883	the duration	872:883	the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability	872:1021	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	2	3	theme	bioprinter	265:274	arg1	parameters					247:256	different parameters	237:256	different parameters of the bioprinter - with the help of simulation software	237:313	The aim of this study is to scrutinize different parameters of the bioprinter - with the help of simulation software - to print a hydrogel so much so that avoid high amounts of shear stress which is detrimental for cell viability and cell proliferation.
33334243	5	4	theme	1.5	857:859	arg1	%					860:860	%	860:860	%	860:860	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	4	5	dep	collagen	637:644	arg1	%					670:670	gelatin (1:4:8)%	655:670	percentages collagen:alginate:gelatin (1:4:8)%	625:670	The results have led to the combination of percentages collagen:alginate:gelatin (1:4:8)% as the best condition which makes sol-gel transition at room temperature possible.
33334243	4	5	dep	collagen	637:644	arg1	alginate					646:653	alginate	646:653	percentages collagen:alginate:gelatin (1:4:8)%	625:670	The results have led to the combination of percentages collagen:alginate:gelatin (1:4:8)% as the best condition which makes sol-gel transition at room temperature possible.
33334243	4	6	theme	gelatin	655:661	arg1	%					670:670	gelatin (1:4:8)%	655:670	percentages collagen:alginate:gelatin (1:4:8)%	625:670	The results have led to the combination of percentages collagen:alginate:gelatin (1:4:8)% as the best condition which makes sol-gel transition at room temperature possible.
33334243	5	7	with	sample	845:850	arg1	CaCl2					862:866	1.5% CaCl2	857:866	1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability	857:1021	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	4	8	dep	percentages	625:635	arg1	collagen					637:644	collagen	637:644	percentages collagen:alginate:gelatin (1:4:8)%	625:670	The results have led to the combination of percentages collagen:alginate:gelatin (1:4:8)% as the best condition which makes sol-gel transition at room temperature possible.
33334243	1	9	theme	widespread	147:156	arg1	use					158:160	widespread use	147:160	widespread use	147:160	In recent decades, three dimensional (3D) bio-printing technology has found widespread use in tissue engineering applications.
33334243	5	10	theme	cell	1008:1011	arg1	viability					1013:1021	cell viability	1008:1021	cell viability	1008:1021	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	3	11	theme	several	482:488	arg1	hydrogels					490:498	several hydrogels	482:498	several hydrogels composed of different percentages of components: alginate, collagen, and gelatin	482:579	Rheology analysis was done on several hydrogels composed of different percentages of components: alginate, collagen, and gelatin.
33334243	3	11	theme	several	482:488	arg1	alginate					549:556	alginate	549:556	alginate	549:556	Rheology analysis was done on several hydrogels composed of different percentages of components: alginate, collagen, and gelatin.
33334243	3	11	theme	several	482:488	arg1	collagen					559:566	collagen	559:566	collagen	559:566	Rheology analysis was done on several hydrogels composed of different percentages of components: alginate, collagen, and gelatin.
33334243	3	11	theme	several	482:488	arg1	gelatin					573:579	gelatin	573:579	gelatin	573:579	Rheology analysis was done on several hydrogels composed of different percentages of components: alginate, collagen, and gelatin.
33334243	5	12	theme	highest	782:788	arg1	rate					800:803	the highest diffusion rate	778:803	the highest diffusion rate	778:803	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	0	13	theme	bioprinted	2:11	arg1	hydrogel					23:30	A bioprinted composite hydrogel	0:30	A bioprinted composite hydrogel with controlled shear stress on cells	0:68	A bioprinted composite hydrogel with controlled shear stress on cells.
33334243	1	14	theme	recent	74:79	arg1	decades					81:87	recent decades	74:87	recent decades	74:87	In recent decades, three dimensional (3D) bio-printing technology has found widespread use in tissue engineering applications.
33334243	5	15	theme	diffusion	790:798	arg1	rate					800:803	the highest diffusion rate	778:803	the highest diffusion rate	778:803	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	5	16	dep	printing	923:930	arg1	hydrogel					936:943	the hydrogel	932:943	printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability	923:1021	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	5	16	dep	printing	923:930	arg1	strong					966:971	strong	966:971	strong	966:971	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	5	17	theme	%	860:860	arg1	CaCl2					862:866	1.5% CaCl2	857:866	1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability	857:1021	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	1	18	theme	tissue	165:170	arg1	applications					184:195	tissue engineering applications	165:195	tissue engineering applications	165:195	In recent decades, three dimensional (3D) bio-printing technology has found widespread use in tissue engineering applications.
33334243	2	19	theme	stress	381:386	arg1	amounts					364:370	high amounts	359:370	high amounts of shear stress which is detrimental for cell viability and cell proliferation	359:449	The aim of this study is to scrutinize different parameters of the bioprinter - with the help of simulation software - to print a hydrogel so much so that avoid high amounts of shear stress which is detrimental for cell viability and cell proliferation.
33334243	2	19	theme	stress	381:386	arg1	stress					381:386	shear stress	375:386	shear stress	375:386	The aim of this study is to scrutinize different parameters of the bioprinter - with the help of simulation software - to print a hydrogel so much so that avoid high amounts of shear stress which is detrimental for cell viability and cell proliferation.
33334243	1	20	theme	engineering	172:182	arg1	applications					184:195	tissue engineering applications	165:195	tissue engineering applications	165:195	In recent decades, three dimensional (3D) bio-printing technology has found widespread use in tissue engineering applications.
33334243	2	21	theme	shear	375:379	arg1	stress					381:386	shear stress	375:386	shear stress	375:386	The aim of this study is to scrutinize different parameters of the bioprinter - with the help of simulation software - to print a hydrogel so much so that avoid high amounts of shear stress which is detrimental for cell viability and cell proliferation.
33334243	3	22	theme	different	512:520	arg1	percentages					522:532	different percentages	512:532	different percentages of components	512:546	Rheology analysis was done on several hydrogels composed of different percentages of components: alginate, collagen, and gelatin.
33334243	5	23	with	strong	966:971	arg1	rate					999:1002	suitable degradation rate	978:1002	suitable degradation rate	978:1002	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	5	23	with	strong	966:971	arg1	viability					1013:1021	cell viability	1008:1021	cell viability	1008:1021	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	4	24	theme	percentages	625:635	arg1	combination					610:620	the combination	606:620	the combination of percentages collagen:alginate:gelatin (1:4:8)%	606:670	The results have led to the combination of percentages collagen:alginate:gelatin (1:4:8)% as the best condition which makes sol-gel transition at room temperature possible.
33334243	0	25	theme	controlled	37:46	arg1	stress					54:59	controlled shear stress	37:59	controlled shear stress	37:59	A bioprinted composite hydrogel with controlled shear stress on cells.
33334243	5	26	dep	1 h.	888:891	arg1	succeeded					910:918	succeeded	910:918	have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability	905:1021	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	2	27	theme	study	214:218	arg1	aim					202:204	The aim	198:204	The aim of this study	198:218	The aim of this study is to scrutinize different parameters of the bioprinter - with the help of simulation software - to print a hydrogel so much so that avoid high amounts of shear stress which is detrimental for cell viability and cell proliferation.
33334243	2	28	theme	high	359:362	arg1	amounts					364:370	high amounts	359:370	high amounts of shear stress which is detrimental for cell viability and cell proliferation	359:449	The aim of this study is to scrutinize different parameters of the bioprinter - with the help of simulation software - to print a hydrogel so much so that avoid high amounts of shear stress which is detrimental for cell viability and cell proliferation.
33334243	2	28	theme	high	359:362	arg1	stress					381:386	shear stress	375:386	shear stress	375:386	The aim of this study is to scrutinize different parameters of the bioprinter - with the help of simulation software - to print a hydrogel so much so that avoid high amounts of shear stress which is detrimental for cell viability and cell proliferation.
33334243	2	29	theme	cell	413:416	arg1	viability					418:426	cell viability	413:426	cell viability	413:426	The aim of this study is to scrutinize different parameters of the bioprinter - with the help of simulation software - to print a hydrogel so much so that avoid high amounts of shear stress which is detrimental for cell viability and cell proliferation.
33334243	5	30	theme	suitable	978:985	arg1	rate					999:1002	suitable degradation rate	978:1002	suitable degradation rate	978:1002	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	4	31	theme	room	728:731	arg1	temperature					733:743	room temperature	728:743	room temperature	728:743	The results have led to the combination of percentages collagen:alginate:gelatin (1:4:8)% as the best condition which makes sol-gel transition at room temperature possible.
33334243	0	32	with	hydrogel	23:30	arg1	stress					54:59	controlled shear stress	37:59	controlled shear stress	37:59	A bioprinted composite hydrogel with controlled shear stress on cells.
33334243	5	33	theme	degradation	987:997	arg1	rate					999:1002	suitable degradation rate	978:1002	suitable degradation rate	978:1002	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	3	34	theme	components	537:546	arg1	percentages					522:532	different percentages	512:532	different percentages of components	512:546	Rheology analysis was done on several hydrogels composed of different percentages of components: alginate, collagen, and gelatin.
33334243	0	35	theme	shear	48:52	arg1	stress					54:59	controlled shear stress	37:59	controlled shear stress	37:59	A bioprinted composite hydrogel with controlled shear stress on cells.
33334243	4	36	from	temperature	733:743	arg1	transition					714:723	sol-gel transition	706:723	sol-gel transition at room temperature	706:743	The results have led to the combination of percentages collagen:alginate:gelatin (1:4:8)% as the best condition which makes sol-gel transition at room temperature possible.
33334243	5	37	theme	cross-linked	832:843	arg1	sample					845:850	the cross-linked sample	828:850	the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability	828:1021	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	4	38	theme	sol-gel	706:712	arg1	transition					714:723	sol-gel transition	706:723	sol-gel transition at room temperature	706:743	The results have led to the combination of percentages collagen:alginate:gelatin (1:4:8)% as the best condition which makes sol-gel transition at room temperature possible.
33334243	2	39	theme	different	237:245	arg1	parameters					247:256	different parameters	237:256	different parameters of the bioprinter - with the help of simulation software	237:313	The aim of this study is to scrutinize different parameters of the bioprinter - with the help of simulation software - to print a hydrogel so much so that avoid high amounts of shear stress which is detrimental for cell viability and cell proliferation.
33334243	2	40	theme	simulation	295:304	arg1	software					306:313	simulation software	295:313	simulation software	295:313	The aim of this study is to scrutinize different parameters of the bioprinter - with the help of simulation software - to print a hydrogel so much so that avoid high amounts of shear stress which is detrimental for cell viability and cell proliferation.
33334243	5	41	link	cross-linked	832:843	arg1	sample					845:850	the cross-linked sample	828:850	the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability	828:1021	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
33334243	4	42	theme	best	679:682	arg1	condition					684:692	the best condition	675:692	the best condition which makes sol-gel transition at room temperature possible	675:752	The results have led to the combination of percentages collagen:alginate:gelatin (1:4:8)% as the best condition which makes sol-gel transition at room temperature possible.
33334243	2	43	dep	the	283:285	arg1	help					287:290	help	287:290	help	287:290	The aim of this study is to scrutinize different parameters of the bioprinter - with the help of simulation software - to print a hydrogel so much so that avoid high amounts of shear stress which is detrimental for cell viability and cell proliferation.
33334243	3	44	dep	hydrogels	490:498	arg1	alginate					549:556	alginate	549:556	alginate	549:556	Rheology analysis was done on several hydrogels composed of different percentages of components: alginate, collagen, and gelatin.
33334243	3	44	dep	hydrogels	490:498	arg1	hydrogels					490:498	several hydrogels	482:498	several hydrogels composed of different percentages of components: alginate, collagen, and gelatin	482:579	Rheology analysis was done on several hydrogels composed of different percentages of components: alginate, collagen, and gelatin.
33334243	3	44	dep	hydrogels	490:498	arg1	collagen					559:566	collagen	559:566	collagen	559:566	Rheology analysis was done on several hydrogels composed of different percentages of components: alginate, collagen, and gelatin.
33334243	3	44	dep	hydrogels	490:498	arg1	gelatin					573:579	gelatin	573:579	gelatin	573:579	Rheology analysis was done on several hydrogels composed of different percentages of components: alginate, collagen, and gelatin.
33334243	1	45	theme	bio-printing	113:124	arg1	technology					126:135	three dimensional (3D) bio-printing technology	90:135	three dimensional (3D) bio-printing technology	90:135	In recent decades, three dimensional (3D) bio-printing technology has found widespread use in tissue engineering applications.
33334243	2	46	with	bioprinter	265:274	arg1	the					283:285	the	283:285	the	283:285	The aim of this study is to scrutinize different parameters of the bioprinter - with the help of simulation software - to print a hydrogel so much so that avoid high amounts of shear stress which is detrimental for cell viability and cell proliferation.
33334243	0	47	from	hydrogel	23:30	arg1	cells					64:68	cells	64:68	cells	64:68	A bioprinted composite hydrogel with controlled shear stress on cells.
33334243	0	48	theme	composite	13:21	arg1	hydrogel					23:30	A bioprinted composite hydrogel	0:30	A bioprinted composite hydrogel with controlled shear stress on cells	0:68	A bioprinted composite hydrogel with controlled shear stress on cells.
33334243	5	49	theme	cell	809:812	arg1	viability					814:822	cell viability	809:822	cell viability	809:822	The results have shown the highest diffusion rate and cell viability for the cross-linked sample with 1.5% CaCl2 for the duration of 1 h. Finally, we have succeeded in printing the hydrogel that is mechanically strong with suitable degradation rate and cell viability.
34756869	2	0	contain	contains	317:324	arg1	Patch					245:249	Patch	245:249	Patch	245:249	Patch is a one of transdermal device that is used to attach on skin and contains drug.
34756869	2	0	contain	contains	317:324	arg1	one					256:258	one	256:258	one	256:258	Patch is a one of transdermal device that is used to attach on skin and contains drug.
34756869	2	0	contain	contains	317:324	arg1	device					275:280	transdermal device	263:280	transdermal device	263:280	Patch is a one of transdermal device that is used to attach on skin and contains drug.
34756869	2	0	contain	contains	317:324	arg2	drug					326:329	drug	326:329	drug	326:329	Patch is a one of transdermal device that is used to attach on skin and contains drug.
34756869	4	1	theme	transdermal	637:647	arg1	patch					649:653	transdermal patch	637:653	transdermal patch	637:653	The pristine HA hydrogels as the matrix and GO as the drug encapsulation host were fabricated for transdermal patch by the solution casting using citric acid as the chemical crosslinker.
34756869	7	2	dep	diffusion	1127:1135	arg1	The					1119:1121	The	1119:1121	The	1119:1121	The TMX diffusion and release amount from the pristine HA hydrogels were increased with smaller crosslinking ratios.
34756869	3	3	theme	tamoxifen	460:468	arg1	citrate					470:476	tamoxifen citrate	460:476	tamoxifen citrate (TMX)	460:482	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	3	3	theme	tamoxifen	460:468	arg1	TMX					479:481	TMX	479:481	TMX	479:481	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	0	4	theme	Stimulated	91:100	arg1	Release					102:108	Electrically Stimulated Release	78:108	Electrically Stimulated Release of Anticancer Tamoxifen Citrate	78:140	Hyaluronic Acid and Graphene Oxide-incorporated Hyaluronic Acid Hydrogels for Electrically Stimulated Release of Anticancer Tamoxifen Citrate.
34756869	3	5	dep	acid	366:369	arg1	hydrogel					416:423	incorporated HA hydrogel	400:423	incorporated HA hydrogel	400:423	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	5	6	theme	crosslinking	844:855	arg1	ratio					857:861	crosslinking ratio	844:861	crosslinking ratio	844:861	In vitro drug release experiment was investigated by utilizing the modified Franz-diffusion cell under the effects of crosslinking ratio, electric potential, and GO.
34756869	3	7	theme	citrate	470:476	arg1	release					449:455	the release	445:455	the release of tamoxifen citrate (TMX)	445:482	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	0	8	theme	Anticancer	113:122	arg1	Citrate					134:140	Anticancer Tamoxifen Citrate	113:140	Anticancer Tamoxifen Citrate	113:140	Hyaluronic Acid and Graphene Oxide-incorporated Hyaluronic Acid Hydrogels for Electrically Stimulated Release of Anticancer Tamoxifen Citrate.
34756869	3	9	from	oxide	389:393	arg1	matrices					341:348	The drug matrices	332:348	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel	332:423	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	3	9	from	oxide	389:393	arg1	drug					502:505	the anticancer drug	487:505	the anticancer drug	487:505	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	9	10	from	hydrogel	1440:1447	arg1	higher					1492:1497	higher	1492:1497	higher	1492:1497	Furthermore, the TMX diffusion from the HA hydrogel with GO as the drug encapsulation host was higher by two orders of magnitude than without GO.
34756869	9	10	from	hydrogel	1440:1447	arg1	diffusion					1418:1426	the TMX diffusion	1410:1426	the TMX diffusion from the HA hydrogel with GO as the drug encapsulation host	1410:1486	Furthermore, the TMX diffusion from the HA hydrogel with GO as the drug encapsulation host was higher by two orders of magnitude than without GO.
34756869	6	11	dep	mechanisms	969:978	arg1	transport					1067:1075	Super case II transport	1053:1075	Super case II transport	1053:1075	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	6	11	dep	mechanisms	969:978	arg1	diffusion					998:1006	the pure Fickian diffusion	981:1006	the pure Fickian diffusion	981:1006	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	6	11	dep	mechanisms	969:978	arg1	mechanisms					969:978	the three mechanisms	959:978	the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport	959:1075	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	6	11	dep	mechanisms	969:978	arg1	diffusion					1038:1046	the anomalous or non-Fickian diffusion	1009:1046	the anomalous or non-Fickian diffusion	1009:1046	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	2	12	used	used	290:293	arg2	device					275:280	transdermal device	263:280	transdermal device	263:280	Patch is a one of transdermal device that is used to attach on skin and contains drug.
34756869	2	12	used	used	290:293	arg2	one					256:258	one	256:258	one	256:258	Patch is a one of transdermal device that is used to attach on skin and contains drug.
34756869	2	12	used	used	290:293	arg2	Patch					245:249	Patch	245:249	Patch	245:249	Patch is a one of transdermal device that is used to attach on skin and contains drug.
34756869	4	13	theme	pristine	543:550	arg1	hydrogels					555:563	The pristine HA hydrogels	539:563	The pristine HA hydrogels as the matrix and GO as the drug encapsulation host	539:615	The pristine HA hydrogels as the matrix and GO as the drug encapsulation host were fabricated for transdermal patch by the solution casting using citric acid as the chemical crosslinker.
34756869	8	14	theme	release	1302:1308	arg1	amount					1310:1315	the enhanced TMX diffusion and release amount	1271:1315	amount	1310:1315	With applied electrical potential, the enhanced TMX diffusion and release amount were observed when compared to that without due to the electro-repulsive force.
34756869	9	15	theme	HA	1437:1438	arg1	hydrogel					1440:1447	the HA hydrogel	1433:1447	the HA hydrogel	1433:1447	Furthermore, the TMX diffusion from the HA hydrogel with GO as the drug encapsulation host was higher by two orders of magnitude than without GO.
34756869	6	16	theme	crosslinking	1094:1105	arg1	conditions					1107:1116	the crosslinking conditions	1090:1116	the crosslinking conditions	1090:1116	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	7	17	theme	pristine	1165:1172	arg1	hydrogels					1177:1185	the pristine HA hydrogels	1161:1185	the pristine HA hydrogels	1161:1185	The TMX diffusion and release amount from the pristine HA hydrogels were increased with smaller crosslinking ratios.
34756869	3	18	theme	anticancer	491:500	arg1	matrices					341:348	The drug matrices	332:348	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel	332:423	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	3	18	theme	anticancer	491:500	arg1	drug					502:505	the anticancer drug	487:505	the anticancer drug	487:505	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	5	19	theme	Franz-diffusion	802:816	arg1	cell					818:821	the modified Franz-diffusion cell	789:821	the modified Franz-diffusion cell	789:821	In vitro drug release experiment was investigated by utilizing the modified Franz-diffusion cell under the effects of crosslinking ratio, electric potential, and GO.
34756869	0	20	theme	Citrate	134:140	arg1	Release					102:108	Electrically Stimulated Release	78:108	Electrically Stimulated Release of Anticancer Tamoxifen Citrate	78:140	Hyaluronic Acid and Graphene Oxide-incorporated Hyaluronic Acid Hydrogels for Electrically Stimulated Release of Anticancer Tamoxifen Citrate.
34756869	3	21	from	acid	366:369	arg1	matrices					341:348	The drug matrices	332:348	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel	332:423	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	3	21	from	acid	366:369	arg1	drug					502:505	the anticancer drug	487:505	the anticancer drug	487:505	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	6	22	from	hydrogels	927:935	arg1	behaviors					908:916	The TMX release behaviors	892:916	The TMX release behaviors from the hydrogels	892:935	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	6	23	theme	anomalous	1013:1021	arg1	mechanisms					969:978	the three mechanisms	959:978	the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport	959:1075	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	6	23	theme	anomalous	1013:1021	arg1	diffusion					1038:1046	the anomalous or non-Fickian diffusion	1009:1046	the anomalous or non-Fickian diffusion	1009:1046	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	9	24	theme	encapsulation	1469:1481	arg1	host					1483:1486	the drug encapsulation host	1460:1486	the drug encapsulation host	1460:1486	Furthermore, the TMX diffusion from the HA hydrogel with GO as the drug encapsulation host was higher by two orders of magnitude than without GO.
34756869	5	25	theme	potential	873:881	arg1	effects					833:839	the effects	829:839	the effects of crosslinking ratio, electric potential, and GO	829:889	In vitro drug release experiment was investigated by utilizing the modified Franz-diffusion cell under the effects of crosslinking ratio, electric potential, and GO.
34756869	1	26	theme	drug	189:192	arg1	delivery					160:167	Transdermal drug delivery	143:167	Transdermal drug delivery	143:167	Transdermal drug delivery is the transport of drug across the skin and into the systemic circulation.
34756869	1	26	theme	drug	189:192	arg1	transport					176:184	the transport	172:184	the transport of drug across the skin and into the systemic circulation	172:242	Transdermal drug delivery is the transport of drug across the skin and into the systemic circulation.
34756869	0	27	theme	Tamoxifen	124:132	arg1	Citrate					134:140	Anticancer Tamoxifen Citrate	113:140	Anticancer Tamoxifen Citrate	113:140	Hyaluronic Acid and Graphene Oxide-incorporated Hyaluronic Acid Hydrogels for Electrically Stimulated Release of Anticancer Tamoxifen Citrate.
34756869	5	28	theme	ratio	857:861	arg1	effects					833:839	the effects	829:839	the effects of crosslinking ratio, electric potential, and GO	829:889	In vitro drug release experiment was investigated by utilizing the modified Franz-diffusion cell under the effects of crosslinking ratio, electric potential, and GO.
34756869	3	29	theme	graphene	380:387	arg1	oxide					389:393	graphene oxide	380:393	graphene oxide (GO)	380:398	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	2	30	theme	device	275:280	arg1	Patch					245:249	Patch	245:249	Patch	245:249	Patch is a one of transdermal device that is used to attach on skin and contains drug.
34756869	2	30	theme	device	275:280	arg1	one					256:258	one	256:258	one	256:258	Patch is a one of transdermal device that is used to attach on skin and contains drug.
34756869	2	30	theme	device	275:280	arg1	device					275:280	transdermal device	263:280	transdermal device	263:280	Patch is a one of transdermal device that is used to attach on skin and contains drug.
34756869	3	31	theme	incorporated	400:411	arg1	hydrogel					416:423	incorporated HA hydrogel	400:423	incorporated HA hydrogel	400:423	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	5	32	theme	release	740:746	arg1	experiment					748:757	In vitro drug release experiment	726:757	In vitro drug release experiment	726:757	In vitro drug release experiment was investigated by utilizing the modified Franz-diffusion cell under the effects of crosslinking ratio, electric potential, and GO.
34756869	6	33	theme	TMX	896:898	arg1	behaviors					908:916	The TMX release behaviors	892:916	The TMX release behaviors from the hydrogels	892:935	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	7	34	theme	release	1141:1147	arg1	amount					1149:1154	release amount	1141:1154	release amount	1141:1154	The TMX diffusion and release amount from the pristine HA hydrogels were increased with smaller crosslinking ratios.
34756869	3	35	theme	applied	513:519	arg1	field					532:536	applied electrical field	513:536	applied electrical field	513:536	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	6	36	theme	Fickian	990:996	arg1	diffusion					998:1006	the pure Fickian diffusion	981:1006	the pure Fickian diffusion	981:1006	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	6	36	theme	Fickian	990:996	arg1	mechanisms					969:978	the three mechanisms	959:978	the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport	959:1075	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	0	37	theme	Hyaluronic	0:9	arg1	Acid					11:14	Hyaluronic Acid	0:14	Hyaluronic Acid	0:14	Hyaluronic Acid and Graphene Oxide-incorporated Hyaluronic Acid Hydrogels for Electrically Stimulated Release of Anticancer Tamoxifen Citrate.
34756869	3	38	dep	oxide	389:393	arg1	GO					396:397	GO	396:397	GO	396:397	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	4	39	theme	drug	593:596	arg1	host					612:615	the drug encapsulation host	589:615	the drug encapsulation host	589:615	The pristine HA hydrogels as the matrix and GO as the drug encapsulation host were fabricated for transdermal patch by the solution casting using citric acid as the chemical crosslinker.
34756869	3	40	theme	electrical	521:530	arg1	field					532:536	applied electrical field	513:536	applied electrical field	513:536	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	4	41	theme	encapsulation	598:610	arg1	host					612:615	the drug encapsulation host	589:615	the drug encapsulation host	589:615	The pristine HA hydrogels as the matrix and GO as the drug encapsulation host were fabricated for transdermal patch by the solution casting using citric acid as the chemical crosslinker.
34756869	3	42	theme	hyaluronic	355:364	arg1	HA					372:373	HA	372:373	HA	372:373	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	3	42	theme	hyaluronic	355:364	arg1	acid					366:369	hyaluronic acid	355:369	hyaluronic acid (HA)	355:374	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	9	43	with	diffusion	1418:1426	arg1	GO					1454:1455	GO	1454:1455	GO	1454:1455	Furthermore, the TMX diffusion from the HA hydrogel with GO as the drug encapsulation host was higher by two orders of magnitude than without GO.
34756869	7	44	from	hydrogels	1177:1185	arg1	diffusion					1127:1135	TMX diffusion	1123:1135	TMX diffusion	1123:1135	The TMX diffusion and release amount from the pristine HA hydrogels were increased with smaller crosslinking ratios.
34756869	7	44	from	hydrogels	1177:1185	arg1	amount					1149:1154	release amount	1141:1154	release amount	1141:1154	The TMX diffusion and release amount from the pristine HA hydrogels were increased with smaller crosslinking ratios.
34756869	5	45	theme	GO	888:889	arg1	effects					833:839	the effects	829:839	the effects of crosslinking ratio, electric potential, and GO	829:889	In vitro drug release experiment was investigated by utilizing the modified Franz-diffusion cell under the effects of crosslinking ratio, electric potential, and GO.
34756869	6	46	theme	release	900:906	arg1	behaviors					908:916	The TMX release behaviors	892:916	The TMX release behaviors from the hydrogels	892:935	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	4	47	theme	citric	685:690	arg1	acid					692:695	citric acid	685:695	citric acid	685:695	The pristine HA hydrogels as the matrix and GO as the drug encapsulation host were fabricated for transdermal patch by the solution casting using citric acid as the chemical crosslinker.
34756869	4	47	theme	citric	685:690	arg1	crosslinker					713:723	the chemical crosslinker	700:723	the chemical crosslinker	700:723	The pristine HA hydrogels as the matrix and GO as the drug encapsulation host were fabricated for transdermal patch by the solution casting using citric acid as the chemical crosslinker.
34756869	7	48	theme	HA	1174:1175	arg1	hydrogels					1177:1185	the pristine HA hydrogels	1161:1185	the pristine HA hydrogels	1161:1185	The TMX diffusion and release amount from the pristine HA hydrogels were increased with smaller crosslinking ratios.
34756869	0	49	theme	Hyaluronic	48:57	arg1	Acid					59:62	Oxide-incorporated Hyaluronic Acid	29:62	Oxide-incorporated Hyaluronic Acid	29:62	Hyaluronic Acid and Graphene Oxide-incorporated Hyaluronic Acid Hydrogels for Electrically Stimulated Release of Anticancer Tamoxifen Citrate.
34756869	5	50	theme	electric	864:871	arg1	potential					873:881	electric potential	864:881	electric potential	864:881	In vitro drug release experiment was investigated by utilizing the modified Franz-diffusion cell under the effects of crosslinking ratio, electric potential, and GO.
34756869	7	51	theme	crosslinking	1215:1226	arg1	ratios					1228:1233	smaller crosslinking ratios	1207:1233	smaller crosslinking ratios	1207:1233	The TMX diffusion and release amount from the pristine HA hydrogels were increased with smaller crosslinking ratios.
34756869	8	52	theme	electrical	1249:1258	arg1	potential					1260:1268	applied electrical potential	1241:1268	applied electrical potential	1241:1268	With applied electrical potential, the enhanced TMX diffusion and release amount were observed when compared to that without due to the electro-repulsive force.
34756869	6	53	theme	pure	985:988	arg1	diffusion					998:1006	the pure Fickian diffusion	981:1006	the pure Fickian diffusion	981:1006	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	6	53	theme	pure	985:988	arg1	mechanisms					969:978	the three mechanisms	959:978	the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport	959:1075	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	3	54	theme	HA	413:414	arg1	hydrogel					416:423	incorporated HA hydrogel	400:423	incorporated HA hydrogel	400:423	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	0	55	theme	Oxide-incorporated	29:46	arg1	Acid					59:62	Oxide-incorporated Hyaluronic Acid	29:62	Oxide-incorporated Hyaluronic Acid	29:62	Hyaluronic Acid and Graphene Oxide-incorporated Hyaluronic Acid Hydrogels for Electrically Stimulated Release of Anticancer Tamoxifen Citrate.
34756869	5	56	theme	In	726:727	arg1	experiment					748:757	In vitro drug release experiment	726:757	In vitro drug release experiment	726:757	In vitro drug release experiment was investigated by utilizing the modified Franz-diffusion cell under the effects of crosslinking ratio, electric potential, and GO.
34756869	1	57	theme	systemic	223:230	arg1	circulation					232:242	the systemic circulation	219:242	the systemic circulation	219:242	Transdermal drug delivery is the transport of drug across the skin and into the systemic circulation.
34756869	7	58	theme	TMX	1123:1125	arg1	diffusion					1127:1135	TMX diffusion	1123:1135	TMX diffusion	1123:1135	The TMX diffusion and release amount from the pristine HA hydrogels were increased with smaller crosslinking ratios.
34756869	5	59	theme	drug	735:738	arg1	experiment					748:757	In vitro drug release experiment	726:757	In vitro drug release experiment	726:757	In vitro drug release experiment was investigated by utilizing the modified Franz-diffusion cell under the effects of crosslinking ratio, electric potential, and GO.
34756869	9	60	theme	magnitude	1516:1524	arg1	orders					1506:1511	two orders	1502:1511	two orders of magnitude	1502:1524	Furthermore, the TMX diffusion from the HA hydrogel with GO as the drug encapsulation host was higher by two orders of magnitude than without GO.
34756869	6	61	theme	Super	1053:1057	arg1	case					1059:1062	Super case II	1053:1065	Super case II transport	1053:1075	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	4	62	theme	HA	552:553	arg1	hydrogels					555:563	The pristine HA hydrogels	539:563	The pristine HA hydrogels as the matrix and GO as the drug encapsulation host	539:615	The pristine HA hydrogels as the matrix and GO as the drug encapsulation host were fabricated for transdermal patch by the solution casting using citric acid as the chemical crosslinker.
34756869	3	63	theme	drug	336:339	arg1	matrices					341:348	The drug matrices	332:348	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel	332:423	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	3	63	theme	drug	336:339	arg1	drug					502:505	the anticancer drug	487:505	the anticancer drug	487:505	The drug matrices from hyaluronic acid (HA) and graphene oxide (GO) incorporated HA hydrogel were fabricated for the release of tamoxifen citrate (TMX) as the anticancer drug under applied electrical field.
34756869	4	64	dep	matrix	572:577	arg1	the					568:570	the	568:570	the	568:570	The pristine HA hydrogels as the matrix and GO as the drug encapsulation host were fabricated for transdermal patch by the solution casting using citric acid as the chemical crosslinker.
34756869	1	65	theme	Transdermal	143:153	arg1	delivery					160:167	Transdermal drug delivery	143:167	Transdermal drug delivery	143:167	Transdermal drug delivery is the transport of drug across the skin and into the systemic circulation.
34756869	1	65	theme	Transdermal	143:153	arg1	transport					176:184	the transport	172:184	the transport of drug across the skin and into the systemic circulation	172:242	Transdermal drug delivery is the transport of drug across the skin and into the systemic circulation.
34756869	8	66	theme	due	1361:1363	arg1	force					1390:1394	due to the electro-repulsive force	1361:1394	due to the electro-repulsive force	1361:1394	With applied electrical potential, the enhanced TMX diffusion and release amount were observed when compared to that without due to the electro-repulsive force.
34756869	2	67	theme	transdermal	263:273	arg1	device					275:280	transdermal device	263:280	transdermal device	263:280	Patch is a one of transdermal device that is used to attach on skin and contains drug.
34756869	1	68	theme	drug	155:158	arg1	delivery					160:167	Transdermal drug delivery	143:167	Transdermal drug delivery	143:167	Transdermal drug delivery is the transport of drug across the skin and into the systemic circulation.
34756869	1	68	theme	drug	155:158	arg1	transport					176:184	the transport	172:184	the transport of drug across the skin and into the systemic circulation	172:242	Transdermal drug delivery is the transport of drug across the skin and into the systemic circulation.
34756869	8	69	theme	TMX	1284:1286	arg1	diffusion					1288:1296	the enhanced TMX diffusion and release amount	1271:1315	diffusion	1288:1296	With applied electrical potential, the enhanced TMX diffusion and release amount were observed when compared to that without due to the electro-repulsive force.
34756869	4	70	theme	chemical	704:711	arg1	acid					692:695	citric acid	685:695	citric acid	685:695	The pristine HA hydrogels as the matrix and GO as the drug encapsulation host were fabricated for transdermal patch by the solution casting using citric acid as the chemical crosslinker.
34756869	4	70	theme	chemical	704:711	arg1	crosslinker					713:723	the chemical crosslinker	700:723	the chemical crosslinker	700:723	The pristine HA hydrogels as the matrix and GO as the drug encapsulation host were fabricated for transdermal patch by the solution casting using citric acid as the chemical crosslinker.
34756869	8	71	theme	enhanced	1275:1282	arg1	diffusion					1288:1296	the enhanced TMX diffusion and release amount	1271:1315	diffusion	1288:1296	With applied electrical potential, the enhanced TMX diffusion and release amount were observed when compared to that without due to the electro-repulsive force.
34756869	8	72	theme	applied	1241:1247	arg1	potential					1260:1268	applied electrical potential	1241:1268	applied electrical potential	1241:1268	With applied electrical potential, the enhanced TMX diffusion and release amount were observed when compared to that without due to the electro-repulsive force.
34756869	4	73	theme	solution	662:669	arg1	casting					671:677	the solution casting	658:677	the solution casting using citric acid as the chemical crosslinker	658:723	The pristine HA hydrogels as the matrix and GO as the drug encapsulation host were fabricated for transdermal patch by the solution casting using citric acid as the chemical crosslinker.
34756869	9	74	theme	TMX	1414:1416	arg1	higher					1492:1497	higher	1492:1497	higher	1492:1497	Furthermore, the TMX diffusion from the HA hydrogel with GO as the drug encapsulation host was higher by two orders of magnitude than without GO.
34756869	9	74	theme	TMX	1414:1416	arg1	diffusion					1418:1426	the TMX diffusion	1410:1426	the TMX diffusion from the HA hydrogel with GO as the drug encapsulation host	1410:1486	Furthermore, the TMX diffusion from the HA hydrogel with GO as the drug encapsulation host was higher by two orders of magnitude than without GO.
34756869	5	75	theme	modified	793:800	arg1	cell					818:821	the modified Franz-diffusion cell	789:821	the modified Franz-diffusion cell	789:821	In vitro drug release experiment was investigated by utilizing the modified Franz-diffusion cell under the effects of crosslinking ratio, electric potential, and GO.
34756869	0	76	dep	Acid	11:14	arg1	Acid					59:62	Oxide-incorporated Hyaluronic Acid	29:62	Oxide-incorporated Hyaluronic Acid	29:62	Hyaluronic Acid and Graphene Oxide-incorporated Hyaluronic Acid Hydrogels for Electrically Stimulated Release of Anticancer Tamoxifen Citrate.
34756869	6	77	theme	non-Fickian	1026:1036	arg1	mechanisms					969:978	the three mechanisms	959:978	the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport	959:1075	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	6	77	theme	non-Fickian	1026:1036	arg1	diffusion					1038:1046	the anomalous or non-Fickian diffusion	1009:1046	the anomalous or non-Fickian diffusion	1009:1046	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	9	78	theme	drug	1464:1467	arg1	host					1483:1486	the drug encapsulation host	1460:1486	the drug encapsulation host	1460:1486	Furthermore, the TMX diffusion from the HA hydrogel with GO as the drug encapsulation host was higher by two orders of magnitude than without GO.
34756869	5	79	dep	In	726:727	arg1	vitro					729:733	vitro	729:733	vitro	729:733	In vitro drug release experiment was investigated by utilizing the modified Franz-diffusion cell under the effects of crosslinking ratio, electric potential, and GO.
34756869	6	80	theme	case	1059:1062	arg1	transport					1067:1075	Super case II transport	1053:1075	Super case II transport	1053:1075	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	6	80	theme	case	1059:1062	arg1	mechanisms					969:978	the three mechanisms	959:978	the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport	959:1075	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	7	81	theme	smaller	1207:1213	arg1	ratios					1228:1233	smaller crosslinking ratios	1207:1233	smaller crosslinking ratios	1207:1233	The TMX diffusion and release amount from the pristine HA hydrogels were increased with smaller crosslinking ratios.
34756869	6	82	theme	or	1023:1024	arg1	mechanisms					969:978	the three mechanisms	959:978	the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport	959:1075	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
34756869	6	82	theme	or	1023:1024	arg1	diffusion					1038:1046	the anomalous or non-Fickian diffusion	1009:1046	the anomalous or non-Fickian diffusion	1009:1046	The TMX release behaviors from the hydrogels were found to be from the three mechanisms: the pure Fickian diffusion; the anomalous or non-Fickian diffusion; and Super case II transport depending on the crosslinking conditions.
32504216	0	0	theme	corneal	99:105	arg1	repair					107:112	corneal repair	99:112	corneal repair	99:112	Preparation of collagen/cellulose nanocrystals composite films and their potential applications in corneal repair.
32504216	8	1	theme	epithelial	1004:1013	arg1	cells					1015:1019	rabbit corneal epithelial cells	989:1019	rabbit corneal epithelial cells	989:1019	The COL/CNC films demonstrated good biocompatibility toward rabbit corneal epithelial cells and keratocytes in vitro.
32504216	9	2	theme	corneal	1145:1151	arg1	cells					1164:1168	corneal epithelial cells	1145:1168	corneal epithelial cells	1145:1168	Moreover, the collagen films with appropriate ration of CNCs effectively induced the migration of corneal epithelial cells and inhibited the myofibroblast differentiation of keratocytes.
32504216	10	3	theme	7 wt	1255:1258	arg1	CNCs					1261:1264	7 wt% CNCs	1255:1264	7 wt% CNCs	1255:1264	A collagen film with 7 wt% CNCs displayed the best combination of physical properties and biological performance in vitro among all the films.
32504216	1	4	theme	repair	230:235	arg1	materials					237:245	corneal repair materials	222:245	corneal repair materials	222:245	As the main component of the natural cornea, collagen (COL) has been widely applied to the construction of corneal repair materials.
32504216	11	5	theme	collagen	1473:1480	arg1	properties					1459:1468	the mechanical properties	1444:1468	the mechanical properties of collagen for use in corneal repair materials	1444:1516	This study describes a nonchemical cross-linking method to enhance the mechanical properties of collagen for use in corneal repair materials and highlights potential application in corneal tissue engineering.
32504216	9	6	with	films	1070:1074	arg1	ration					1093:1098	appropriate ration	1081:1098	appropriate ration of CNCs	1081:1106	Moreover, the collagen films with appropriate ration of CNCs effectively induced the migration of corneal epithelial cells and inhibited the myofibroblast differentiation of keratocytes.
32504216	8	7	theme	corneal	996:1002	arg1	cells					1015:1019	rabbit corneal epithelial cells	989:1019	rabbit corneal epithelial cells	989:1019	The COL/CNC films demonstrated good biocompatibility toward rabbit corneal epithelial cells and keratocytes in vitro.
32504216	8	8	theme	COL/CNC	933:939	arg1	films					941:945	The COL/CNC films	929:945	The COL/CNC films	929:945	The COL/CNC films demonstrated good biocompatibility toward rabbit corneal epithelial cells and keratocytes in vitro.
32504216	11	9	theme	repair	1501:1506	arg1	materials					1508:1516	corneal repair materials	1493:1516	corneal repair materials	1493:1516	This study describes a nonchemical cross-linking method to enhance the mechanical properties of collagen for use in corneal repair materials and highlights potential application in corneal tissue engineering.
32504216	1	10	theme	materials	237:245	arg1	construction					206:217	the construction	202:217	the construction of corneal repair materials	202:245	As the main component of the natural cornea, collagen (COL) has been widely applied to the construction of corneal repair materials.
32504216	3	11	theme	Cellulose	337:345	arg1	CNCs					361:364	CNCs	361:364	CNCs	361:364	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	3	11	theme	Cellulose	337:345	arg1	nanocrystals					347:358	Cellulose nanocrystals	337:358	Cellulose nanocrystals (CNCs)	337:365	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	0	12	from	Preparation	0:10	arg1	repair					107:112	corneal repair	99:112	corneal repair	99:112	Preparation of collagen/cellulose nanocrystals composite films and their potential applications in corneal repair.
32504216	11	13	theme	nonchemical	1400:1410	arg1	method					1426:1431	a nonchemical cross-linking method	1398:1431	a nonchemical cross-linking method to enhance the mechanical properties of collagen for use in corneal repair materials	1398:1516	This study describes a nonchemical cross-linking method to enhance the mechanical properties of collagen for use in corneal repair materials and highlights potential application in corneal tissue engineering.
32504216	9	14	theme	cells	1164:1168	arg1	migration					1132:1140	the migration	1128:1140	the migration of corneal epithelial cells	1128:1168	Moreover, the collagen films with appropriate ration of CNCs effectively induced the migration of corneal epithelial cells and inhibited the myofibroblast differentiation of keratocytes.
32504216	11	15	from	application	1543:1553	arg1	engineering					1573:1583	corneal tissue engineering	1558:1583	corneal tissue engineering	1558:1583	This study describes a nonchemical cross-linking method to enhance the mechanical properties of collagen for use in corneal repair materials and highlights potential application in corneal tissue engineering.
32504216	11	16	theme	cross-linking	1412:1424	arg1	method					1426:1431	a nonchemical cross-linking method	1398:1431	a nonchemical cross-linking method to enhance the mechanical properties of collagen for use in corneal repair materials	1398:1516	This study describes a nonchemical cross-linking method to enhance the mechanical properties of collagen for use in corneal repair materials and highlights potential application in corneal tissue engineering.
32504216	10	17	theme	performance	1335:1345	arg1	combination					1285:1295	the best combination	1276:1295	the best combination of physical properties and biological performance	1276:1345	A collagen film with 7 wt% CNCs displayed the best combination of physical properties and biological performance in vitro among all the films.
32504216	11	18	theme	potential	1533:1541	arg1	application					1543:1553	potential application	1533:1553	potential application in corneal tissue engineering	1533:1583	This study describes a nonchemical cross-linking method to enhance the mechanical properties of collagen for use in corneal repair materials and highlights potential application in corneal tissue engineering.
32504216	11	19	theme	mechanical	1448:1457	arg1	properties					1459:1468	the mechanical properties	1444:1468	the mechanical properties of collagen for use in corneal repair materials	1444:1516	This study describes a nonchemical cross-linking method to enhance the mechanical properties of collagen for use in corneal repair materials and highlights potential application in corneal tissue engineering.
32504216	6	20	theme	physical	667:674	arg1	properties					676:685	The physical properties	663:685	The physical properties of these composite films	663:710	The physical properties of these composite films were characterized, and in vitro cell-based analyses were also performed.
32504216	9	21	theme	collagen	1061:1068	arg1	films					1070:1074	the collagen films	1057:1074	the collagen films with appropriate ration of CNCs	1057:1106	Moreover, the collagen films with appropriate ration of CNCs effectively induced the migration of corneal epithelial cells and inhibited the myofibroblast differentiation of keratocytes.
32504216	1	22	theme	main	122:125	arg1	component					127:135	the main component	118:135	the main component of the natural cornea	118:157	As the main component of the natural cornea, collagen (COL) has been widely applied to the construction of corneal repair materials.
32504216	1	22	theme	main	122:125	arg1	collagen					160:167	collagen	160:167	collagen (COL)	160:173	As the main component of the natural cornea, collagen (COL) has been widely applied to the construction of corneal repair materials.
32504216	10	23	theme	best	1280:1283	arg1	combination					1285:1295	the best combination	1276:1295	the best combination of physical properties and biological performance	1276:1345	A collagen film with 7 wt% CNCs displayed the best combination of physical properties and biological performance in vitro among all the films.
32504216	7	24	theme	light	908:912	arg1	transmittance					914:926	light transmittance	908:926	light transmittance	908:926	The COL/CNC films possessed better mechanic properties, and the introduction of CNCs did not affect the water content and light transmittance.
32504216	11	25	from	use	1486:1488	arg1	materials					1508:1516	corneal repair materials	1493:1516	corneal repair materials	1493:1516	This study describes a nonchemical cross-linking method to enhance the mechanical properties of collagen for use in corneal repair materials and highlights potential application in corneal tissue engineering.
32504216	9	26	theme	myofibroblast	1188:1200	arg1	differentiation					1202:1216	the myofibroblast differentiation	1184:1216	the myofibroblast differentiation of keratocytes	1184:1231	Moreover, the collagen films with appropriate ration of CNCs effectively induced the migration of corneal epithelial cells and inhibited the myofibroblast differentiation of keratocytes.
32504216	6	27	theme	cell-based	745:754	arg1	analyses					756:763	in vitro cell-based analyses	736:763	in vitro cell-based analyses	736:763	The physical properties of these composite films were characterized, and in vitro cell-based analyses were also performed.
32504216	3	28	theme	good	433:436	arg1	properties					396:405	excellent mechanical properties	375:405	excellent mechanical properties	375:405	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	3	28	theme	good	433:436	arg1	biocompatibility					438:453	good biocompatibility	433:453	good biocompatibility	433:453	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	6	29	dep	in	736:737	arg1	vitro					739:743	vitro	739:743	vitro	739:743	The physical properties of these composite films were characterized, and in vitro cell-based analyses were also performed.
32504216	8	30	theme	good	960:963	arg1	biocompatibility					965:980	good biocompatibility	960:980	good biocompatibility toward rabbit corneal epithelial cells and keratocytes	960:1035	The COL/CNC films demonstrated good biocompatibility toward rabbit corneal epithelial cells and keratocytes in vitro.
32504216	7	31	theme	better	814:819	arg1	properties					830:839	better mechanic properties	814:839	better mechanic properties	814:839	The COL/CNC films possessed better mechanic properties, and the introduction of CNCs did not affect the water content and light transmittance.
32504216	3	32	theme	optical	408:414	arg1	properties					396:405	excellent mechanical properties	375:405	excellent mechanical properties	375:405	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	3	32	theme	optical	408:414	arg1	transparency					416:427	optical transparency	408:427	optical transparency	408:427	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	3	33	contain	possess	367:373	arg2	properties					396:405	excellent mechanical properties	375:405	excellent mechanical properties	375:405	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	3	33	contain	possess	367:373	arg2	biocompatibility					438:453	good biocompatibility	433:453	good biocompatibility	433:453	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	3	33	contain	possess	367:373	arg1	CNCs					361:364	CNCs	361:364	CNCs	361:364	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	3	33	contain	possess	367:373	arg2	transparency					416:427	optical transparency	408:427	optical transparency	408:427	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	3	33	contain	possess	367:373	arg1	nanocrystals					347:358	Cellulose nanocrystals	337:358	Cellulose nanocrystals (CNCs)	337:365	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	11	34	theme	tissue	1566:1571	arg1	engineering					1573:1583	corneal tissue engineering	1558:1583	corneal tissue engineering	1558:1583	This study describes a nonchemical cross-linking method to enhance the mechanical properties of collagen for use in corneal repair materials and highlights potential application in corneal tissue engineering.
32504216	7	35	theme	COL/CNC	790:796	arg1	films					798:802	The COL/CNC films	786:802	The COL/CNC films	786:802	The COL/CNC films possessed better mechanic properties, and the introduction of CNCs did not affect the water content and light transmittance.
32504216	8	36	theme	rabbit	989:994	arg1	cells					1015:1019	rabbit corneal epithelial cells	989:1019	rabbit corneal epithelial cells	989:1019	The COL/CNC films demonstrated good biocompatibility toward rabbit corneal epithelial cells and keratocytes in vitro.
32504216	0	37	theme	nanocrystals	34:45	arg1	films					57:61	collagen/cellulose nanocrystals composite films	15:61	collagen/cellulose nanocrystals composite films	15:61	Preparation of collagen/cellulose nanocrystals composite films and their potential applications in corneal repair.
32504216	6	38	theme	in	736:737	arg1	analyses					756:763	in vitro cell-based analyses	736:763	in vitro cell-based analyses	736:763	The physical properties of these composite films were characterized, and in vitro cell-based analyses were also performed.
32504216	9	39	theme	epithelial	1153:1162	arg1	cells					1164:1168	corneal epithelial cells	1145:1168	corneal epithelial cells	1145:1168	Moreover, the collagen films with appropriate ration of CNCs effectively induced the migration of corneal epithelial cells and inhibited the myofibroblast differentiation of keratocytes.
32504216	0	40	theme	collagen/cellulose	15:32	arg1	films					57:61	collagen/cellulose nanocrystals composite films	15:61	collagen/cellulose nanocrystals composite films	15:61	Preparation of collagen/cellulose nanocrystals composite films and their potential applications in corneal repair.
32504216	4	41	theme	corneal	567:573	arg1	materials					582:590	corneal repair materials	567:590	corneal repair materials	567:590	Therefore, in this study, we attempted to introduce cellulose nanocrystals into collagen-based films to obtain corneal repair materials with a high strength.
32504216	9	42	theme	keratocytes	1221:1231	arg1	differentiation					1202:1216	the myofibroblast differentiation	1184:1216	the myofibroblast differentiation of keratocytes	1184:1231	Moreover, the collagen films with appropriate ration of CNCs effectively induced the migration of corneal epithelial cells and inhibited the myofibroblast differentiation of keratocytes.
32504216	2	43	theme	collagen	277:284	arg1	applications					261:272	the applications	257:272	the applications of collagen	257:284	However, the applications of collagen are limited due to its poor mechanical properties.
32504216	2	43	theme	collagen	277:284	arg1	limited					290:296	limited	290:296	limited	290:296	However, the applications of collagen are limited due to its poor mechanical properties.
32504216	9	44	theme	appropriate	1081:1091	arg1	ration					1093:1098	appropriate ration	1081:1098	appropriate ration of CNCs	1081:1106	Moreover, the collagen films with appropriate ration of CNCs effectively induced the migration of corneal epithelial cells and inhibited the myofibroblast differentiation of keratocytes.
32504216	10	45	theme	properties	1309:1318	arg1	combination					1285:1295	the best combination	1276:1295	the best combination of physical properties and biological performance	1276:1345	A collagen film with 7 wt% CNCs displayed the best combination of physical properties and biological performance in vitro among all the films.
32504216	0	46	theme	films	57:61	arg1	Preparation					0:10	Preparation	0:10	Preparation of collagen/cellulose nanocrystals composite films	0:61	Preparation of collagen/cellulose nanocrystals composite films and their potential applications in corneal repair.
32504216	0	46	theme	films	57:61	arg1	applications					83:94	their potential applications	67:94	their potential applications in corneal repair	67:112	Preparation of collagen/cellulose nanocrystals composite films and their potential applications in corneal repair.
32504216	11	47	theme	corneal	1558:1564	arg1	engineering					1573:1583	corneal tissue engineering	1558:1583	corneal tissue engineering	1558:1583	This study describes a nonchemical cross-linking method to enhance the mechanical properties of collagen for use in corneal repair materials and highlights potential application in corneal tissue engineering.
32504216	0	48	theme	composite	47:55	arg1	films					57:61	collagen/cellulose nanocrystals composite films	15:61	collagen/cellulose nanocrystals composite films	15:61	Preparation of collagen/cellulose nanocrystals composite films and their potential applications in corneal repair.
32504216	4	49	theme	repair	575:580	arg1	materials					582:590	corneal repair materials	567:590	corneal repair materials	567:590	Therefore, in this study, we attempted to introduce cellulose nanocrystals into collagen-based films to obtain corneal repair materials with a high strength.
32504216	0	50	from	applications	83:94	arg1	repair					107:112	corneal repair	99:112	corneal repair	99:112	Preparation of collagen/cellulose nanocrystals composite films and their potential applications in corneal repair.
32504216	7	51	theme	mechanic	821:828	arg1	properties					830:839	better mechanic properties	814:839	better mechanic properties	814:839	The COL/CNC films possessed better mechanic properties, and the introduction of CNCs did not affect the water content and light transmittance.
32504216	3	52	theme	excellent	375:383	arg1	properties					396:405	excellent mechanical properties	375:405	excellent mechanical properties	375:405	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	3	52	theme	excellent	375:383	arg1	transparency					416:427	optical transparency	408:427	optical transparency	408:427	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	3	52	theme	excellent	375:383	arg1	biocompatibility					438:453	good biocompatibility	433:453	good biocompatibility	433:453	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	4	53	theme	cellulose	508:516	arg1	nanocrystals					518:529	cellulose nanocrystals	508:529	cellulose nanocrystals	508:529	Therefore, in this study, we attempted to introduce cellulose nanocrystals into collagen-based films to obtain corneal repair materials with a high strength.
32504216	9	54	theme	CNCs	1103:1106	arg1	ration					1093:1098	appropriate ration	1081:1098	appropriate ration of CNCs	1081:1106	Moreover, the collagen films with appropriate ration of CNCs effectively induced the migration of corneal epithelial cells and inhibited the myofibroblast differentiation of keratocytes.
32504216	2	55	theme	mechanical	314:323	arg1	properties					325:334	its poor mechanical properties	305:334	its poor mechanical properties	305:334	However, the applications of collagen are limited due to its poor mechanical properties.
32504216	3	56	theme	mechanical	385:394	arg1	properties					396:405	excellent mechanical properties	375:405	excellent mechanical properties	375:405	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	3	56	theme	mechanical	385:394	arg1	transparency					416:427	optical transparency	408:427	optical transparency	408:427	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	3	56	theme	mechanical	385:394	arg1	biocompatibility					438:453	good biocompatibility	433:453	good biocompatibility	433:453	Cellulose nanocrystals (CNCs) possess excellent mechanical properties, optical transparency and good biocompatibility.
32504216	4	57	theme	collagen-based	536:549	arg1	films					551:555	collagen-based films	536:555	collagen-based films	536:555	Therefore, in this study, we attempted to introduce cellulose nanocrystals into collagen-based films to obtain corneal repair materials with a high strength.
32504216	7	58	contain	possessed	804:812	arg2	properties					830:839	better mechanic properties	814:839	better mechanic properties	814:839	The COL/CNC films possessed better mechanic properties, and the introduction of CNCs did not affect the water content and light transmittance.
32504216	7	58	contain	possessed	804:812	arg1	films					798:802	The COL/CNC films	786:802	The COL/CNC films	786:802	The COL/CNC films possessed better mechanic properties, and the introduction of CNCs did not affect the water content and light transmittance.
32504216	10	59	theme	biological	1324:1333	arg1	performance					1335:1345	biological performance	1324:1345	biological performance	1324:1345	A collagen film with 7 wt% CNCs displayed the best combination of physical properties and biological performance in vitro among all the films.
32504216	2	60	theme	poor	309:312	arg1	properties					325:334	its poor mechanical properties	305:334	its poor mechanical properties	305:334	However, the applications of collagen are limited due to its poor mechanical properties.
32504216	10	61	theme	collagen	1236:1243	arg1	film					1245:1248	A collagen film	1234:1248	A collagen film with 7 wt% CNCs	1234:1264	A collagen film with 7 wt% CNCs displayed the best combination of physical properties and biological performance in vitro among all the films.
32504216	7	62	theme	water	890:894	arg1	content					896:902	the water content	886:902	the water content	886:902	The COL/CNC films possessed better mechanic properties, and the introduction of CNCs did not affect the water content and light transmittance.
32504216	6	63	theme	films	706:710	arg1	properties					676:685	The physical properties	663:685	The physical properties of these composite films	663:710	The physical properties of these composite films were characterized, and in vitro cell-based analyses were also performed.
32504216	11	64	theme	corneal	1493:1499	arg1	materials					1508:1516	corneal repair materials	1493:1516	corneal repair materials	1493:1516	This study describes a nonchemical cross-linking method to enhance the mechanical properties of collagen for use in corneal repair materials and highlights potential application in corneal tissue engineering.
32504216	6	65	theme	composite	696:704	arg1	films					706:710	these composite films	690:710	these composite films	690:710	The physical properties of these composite films were characterized, and in vitro cell-based analyses were also performed.
32504216	10	66	theme	physical	1300:1307	arg1	properties					1309:1318	physical properties	1300:1318	physical properties	1300:1318	A collagen film with 7 wt% CNCs displayed the best combination of physical properties and biological performance in vitro among all the films.
32504216	4	67	theme	high	599:602	arg1	strength					604:611	a high strength	597:611	a high strength	597:611	Therefore, in this study, we attempted to introduce cellulose nanocrystals into collagen-based films to obtain corneal repair materials with a high strength.
32504216	10	68	with	film	1245:1248	arg1	CNCs					1261:1264	7 wt% CNCs	1255:1264	7 wt% CNCs	1255:1264	A collagen film with 7 wt% CNCs displayed the best combination of physical properties and biological performance in vitro among all the films.
32504216	1	69	theme	natural	144:150	arg1	cornea					152:157	the natural cornea	140:157	the natural cornea	140:157	As the main component of the natural cornea, collagen (COL) has been widely applied to the construction of corneal repair materials.
32504216	7	70	theme	CNCs	866:869	arg1	introduction					850:861	the introduction	846:861	the introduction of CNCs	846:869	The COL/CNC films possessed better mechanic properties, and the introduction of CNCs did not affect the water content and light transmittance.
32504216	0	71	theme	potential	73:81	arg1	applications					83:94	their potential applications	67:94	their potential applications in corneal repair	67:112	Preparation of collagen/cellulose nanocrystals composite films and their potential applications in corneal repair.
32504216	1	72	theme	cornea	152:157	arg1	component					127:135	the main component	118:135	the main component of the natural cornea	118:157	As the main component of the natural cornea, collagen (COL) has been widely applied to the construction of corneal repair materials.
32504216	1	72	theme	cornea	152:157	arg1	collagen					160:167	collagen	160:167	collagen (COL)	160:173	As the main component of the natural cornea, collagen (COL) has been widely applied to the construction of corneal repair materials.
32504216	10	73	theme	%	1259:1259	arg1	CNCs					1261:1264	7 wt% CNCs	1255:1264	7 wt% CNCs	1255:1264	A collagen film with 7 wt% CNCs displayed the best combination of physical properties and biological performance in vitro among all the films.
32504216	1	74	theme	corneal	222:228	arg1	materials					237:245	corneal repair materials	222:245	corneal repair materials	222:245	As the main component of the natural cornea, collagen (COL) has been widely applied to the construction of corneal repair materials.
33252063	7	0	theme	bone	1165:1168	arg1	carrier					1131:1137	 encapsulation carrier o	1114:1137	 encapsulation carrier of drugs a	1114:1146	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	7	0	theme	bone	1165:1168	arg1	potential					1101:1109	omising potential a	1091:1109	omising potential a	1091:1109	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	7	0	theme	bone	1165:1168	arg1	component					1152:1160	mponent o	1152:1160	mponent of bone substitutes.	1152:1180	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	2	1	theme	ceramic	371:377	arg1	microbeads					379:388	alginate/calcium phosphate (CaP) ceramic microbeads	338:388	alginate/calcium phosphate (CaP) ceramic microbeads	338:388	OBJECTIVE This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices.
33252063	4	2	from	microbeads	745:754	arg1	environment					771:781	e aqueous environment w	759:781	e aqueous environment w	759:781	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	6	3	theme	CaP	1037:1039	arg1	addition					1025:1032	e addition o	1021:1032	e addition of CaP. 	1021:1039	e initial release rate of the model drug methylene blue was suppressed by the addition of CaP. C
33252063	0	4	theme	comparative	73:83	arg1	study					85:89	A comparative study	71:89	A comparative study	71:89	Fabrication and properties of alginate/calcium phosphate hybrid beads: A comparative study.
33252063	6	5	theme	release	957:963	arg1	rate					965:968	e initial release rate o	945:968	e initial release rate of the model drug methylene blue w	945:1001	e initial release rate of the model drug methylene blue was suppressed by the addition of CaP. C
33252063	4	6	theme	microbeads	745:754	arg1	RESULTS					675:681	SULTS Porosity, swelling properties and in vitro degradation o	675:736	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment w	675:781	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	4	6	theme	microbeads	745:754	arg1	Porosity					683:690	rosity, 	683:690	rosity, 	683:690	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	4	6	theme	microbeads	745:754	arg1	degradation					726:736	 vitro degradation o	717:736	 vitro degradation o	717:736	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	1	7	theme	clinical	196:203	arg1	applications					205:216	clinical applications	196:216	clinical applications	196:216	BACKGROUND Microbeads for bone repair have been widely studied because they can be conveniently used in clinical applications.
33252063	6	8	theme	initial	949:955	arg1	rate					965:968	e initial release rate o	945:968	e initial release rate of the model drug methylene blue w	945:1001	e initial release rate of the model drug methylene blue was suppressed by the addition of CaP. C
33252063	5	9	theme	CaP	940:942	arg1	type					932:935	e type o	928:935	e type of CaP. 	928:942	e compressive strength of the blocks fabricated from the beads was around 120 MPa irrespective of the type of CaP. T
33252063	3	10	theme	𝛽-tricalcium	599:611	arg1	alginate					541:548	alginate	541:548	alginate	541:548	METHODS Hybrid microbeads were successfully prepared from sodium alginate and various CaP, namely 𝛼-tricalcium phosphate, 𝛽-tricalcium phosphate and hydroxyapatite using the liquid droplet method. R
33252063	3	10	theme	𝛽-tricalcium	599:611	arg1	phosphate					613:621	-tricalcium phosphate a	599:621	-tricalcium phosphate a	599:621	METHODS Hybrid microbeads were successfully prepared from sodium alginate and various CaP, namely 𝛼-tricalcium phosphate, 𝛽-tricalcium phosphate and hydroxyapatite using the liquid droplet method. R
33252063	3	11	theme	𝛼-tricalcium	574:586	arg1	alginate					541:548	alginate	541:548	alginate	541:548	METHODS Hybrid microbeads were successfully prepared from sodium alginate and various CaP, namely 𝛼-tricalcium phosphate, 𝛽-tricalcium phosphate and hydroxyapatite using the liquid droplet method. R
33252063	3	11	theme	𝛼-tricalcium	574:586	arg1	phosphate					588:596	𝛼-tricalcium phosphate,	574:596	𝛼-tricalcium phosphate,	574:596	METHODS Hybrid microbeads were successfully prepared from sodium alginate and various CaP, namely 𝛼-tricalcium phosphate, 𝛽-tricalcium phosphate and hydroxyapatite using the liquid droplet method. R
33252063	2	12	theme	in vitro	290:297	arg1	characterisation					299:314	in vitro characterisation	290:314	in vitro characterisation	290:314	OBJECTIVE This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices.
33252063	5	13	theme	irrespective	912:923	arg1	120 MPa					904:910	0 MPa i	904:910	0 MPa irrespective of the type of CaP. 	904:942	e compressive strength of the blocks fabricated from the beads was around 120 MPa irrespective of the type of CaP. T
33252063	4	14	theme	aqueous	763:769	arg1	environment					771:781	e aqueous environment w	759:781	e aqueous environment w	759:781	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	7	15	theme	drugs	1142:1146	arg1	carrier					1131:1137	 encapsulation carrier o	1114:1137	 encapsulation carrier of drugs a	1114:1146	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	7	15	theme	drugs	1142:1146	arg1	potential					1101:1109	omising potential a	1091:1109	omising potential a	1091:1109	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	7	15	theme	drugs	1142:1146	arg1	component					1152:1160	mponent o	1152:1160	mponent of bone substitutes.	1152:1180	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	2	16	dep	OBJECTIVE	219:227	arg1	concerns					240:247	concerns	240:247	concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices	240:473	OBJECTIVE This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices.
33252063	7	17	dep	CONCLUSION	1042:1051	arg1	hold					1086:1089	ld p	1086:1089	ld promising potential as an encapsulation carrier of drugs and component of bone substitutes.	1086:1180	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	2	18	dep	preparation	253:263	arg1	the					249:251	the	249:251	the	249:251	OBJECTIVE This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices.
33252063	5	19	theme	compressive	832:842	arg1	strength					844:851	e compressive strength o	828:851	e compressive strength of the blocks fabricated from the beads w	828:891	e compressive strength of the blocks fabricated from the beads was around 120 MPa irrespective of the type of CaP. T
33252063	5	20	theme	blocks	860:865	arg1	strength					844:851	e compressive strength o	828:851	e compressive strength of the blocks fabricated from the beads w	828:891	e compressive strength of the blocks fabricated from the beads was around 120 MPa irrespective of the type of CaP. T
33252063	0	21	dep	study	85:89	arg1	properties					16:25	properties	16:25	properties	16:25	Fabrication and properties of alginate/calcium phosphate hybrid beads: A comparative study.
33252063	0	21	dep	study	85:89	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and properties of alginate/calcium phosphate hybrid beads: A comparative study.
33252063	2	22	theme	bone-regeneration	448:464	arg1	matrices					466:473	bone-regeneration matrices	448:473	bone-regeneration matrices	448:473	OBJECTIVE This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices.
33252063	1	23	theme	BACKGROUND	92:101	arg1	Microbeads					103:112	BACKGROUND Microbeads	92:112	BACKGROUND Microbeads for bone repair	92:128	BACKGROUND Microbeads for bone repair have been widely studied because they can be conveniently used in clinical applications.
33252063	4	24	theme	in vitro	717:724	arg1	RESULTS					675:681	SULTS Porosity, swelling properties and in vitro degradation o	675:736	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment w	675:781	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	4	24	theme	in vitro	717:724	arg1	degradation					726:736	 vitro degradation o	717:736	 vitro degradation o	717:736	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	7	25	dep	bone	1165:1168	arg1	substitutes					1170:1180	bstitutes.	1170:1180	bstitutes.	1170:1180	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	2	26	theme	different	319:327	arg1	types					329:333	different types	319:333	different types	319:333	OBJECTIVE This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices.
33252063	2	27	theme	delivery	427:434	arg1	systems					436:442	drug delivery systems	422:442	drug delivery systems	422:442	OBJECTIVE This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices.
33252063	2	28	theme	types	329:333	arg1	preparation					253:263	preparation	253:263	preparation	253:263	OBJECTIVE This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices.
33252063	2	28	theme	types	329:333	arg1	properties					275:284	physical properties	266:284	physical properties	266:284	OBJECTIVE This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices.
33252063	2	28	theme	types	329:333	arg1	characterisation					299:314	in vitro characterisation	290:314	in vitro characterisation	290:314	OBJECTIVE This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices.
33252063	7	29	theme	encapsulation	1117:1129	arg1	carrier					1131:1137	 encapsulation carrier o	1114:1137	 encapsulation carrier of drugs a	1114:1146	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	7	29	theme	encapsulation	1117:1129	arg1	potential					1101:1109	omising potential a	1091:1109	omising potential a	1091:1109	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	2	30	theme	drug	422:425	arg1	systems					436:442	drug delivery systems	422:442	drug delivery systems	422:442	OBJECTIVE This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices.
33252063	0	31	theme	phosphate	47:55	arg1	beads					64:68	alginate/calcium phosphate hybrid beads	30:68	alginate/calcium phosphate hybrid beads	30:68	Fabrication and properties of alginate/calcium phosphate hybrid beads: A comparative study.
33252063	6	32	theme	blue	998:1001	arg1	methylene					988:996	e model drug methylene blue w	973:1001	e model drug methylene blue w	973:1001	e initial release rate of the model drug methylene blue was suppressed by the addition of CaP. C
33252063	4	33	from	RESULTS	675:681	arg1	environment					771:781	e aqueous environment w	759:781	e aqueous environment w	759:781	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	4	34	theme	swelling	693:700	arg1	properties					702:711	elling properties a	693:711	elling properties a	693:711	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	0	35	theme	alginate/calcium	30:45	arg1	beads					64:68	alginate/calcium phosphate hybrid beads	30:68	alginate/calcium phosphate hybrid beads	30:68	Fabrication and properties of alginate/calcium phosphate hybrid beads: A comparative study.
33252063	6	36	theme	methylene	988:996	arg1	rate					965:968	e initial release rate o	945:968	e initial release rate of the model drug methylene blue w	945:1001	e initial release rate of the model drug methylene blue was suppressed by the addition of CaP. C
33252063	4	37	theme	added	817:821	arg1	CaP					823:825	e added CaP. 	813:825	e added CaP. 	813:825	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	3	38	theme	METHODS	476:482	arg1	microbeads					491:500	METHODS Hybrid microbeads	476:500	METHODS Hybrid microbeads	476:500	METHODS Hybrid microbeads were successfully prepared from sodium alginate and various CaP, namely 𝛼-tricalcium phosphate, 𝛽-tricalcium phosphate and hydroxyapatite using the liquid droplet method. R
33252063	0	39	theme	beads	64:68	arg1	properties					16:25	properties	16:25	properties	16:25	Fabrication and properties of alginate/calcium phosphate hybrid beads: A comparative study.
33252063	0	39	theme	beads	64:68	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and properties of alginate/calcium phosphate hybrid beads: A comparative study.
33252063	6	40	theme	drug	983:986	arg1	methylene					988:996	e model drug methylene blue w	973:1001	e model drug methylene blue w	973:1001	e initial release rate of the model drug methylene blue was suppressed by the addition of CaP. C
33252063	7	41	theme	alginate-CaP	1057:1068	arg1	beads					1080:1084	e alginate-CaP composite beads h	1053:1084	e alginate-CaP composite beads h	1053:1084	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	1	42	theme	bone	118:121	arg1	repair					123:128	bone repair	118:128	bone repair	118:128	BACKGROUND Microbeads for bone repair have been widely studied because they can be conveniently used in clinical applications.
33252063	0	43	theme	hybrid	57:62	arg1	beads					64:68	alginate/calcium phosphate hybrid beads	30:68	alginate/calcium phosphate hybrid beads	30:68	Fabrication and properties of alginate/calcium phosphate hybrid beads: A comparative study.
33252063	6	44	theme	model	977:981	arg1	methylene					988:996	e model drug methylene blue w	973:1001	e model drug methylene blue w	973:1001	e initial release rate of the model drug methylene blue was suppressed by the addition of CaP. C
33252063	7	45	theme	promising	1091:1099	arg1	carrier					1131:1137	 encapsulation carrier o	1114:1137	 encapsulation carrier of drugs a	1114:1146	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	7	45	theme	promising	1091:1099	arg1	potential					1101:1109	omising potential a	1091:1109	omising potential a	1091:1109	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	4	46	dep	RESULTS	675:681	arg1	RESULTS					675:681	SULTS Porosity, swelling properties and in vitro degradation o	675:736	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment w	675:781	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	4	46	dep	RESULTS	675:681	arg1	Porosity					683:690	rosity, 	683:690	rosity, 	683:690	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	4	46	dep	RESULTS	675:681	arg1	properties					702:711	elling properties a	693:711	elling properties a	693:711	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	4	46	dep	RESULTS	675:681	arg1	degradation					726:736	 vitro degradation o	717:736	 vitro degradation o	717:736	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	7	47	theme	composite	1070:1078	arg1	beads					1080:1084	e alginate-CaP composite beads h	1053:1084	e alginate-CaP composite beads h	1053:1084	NCLUSION The alginate-CaP composite beads hold promising potential as an encapsulation carrier of drugs and component of bone substitutes.
33252063	1	48	used	used	188:191	arg2	they					163:166	they	163:166	they	163:166	BACKGROUND Microbeads for bone repair have been widely studied because they can be conveniently used in clinical applications.
33252063	2	49	theme	physical	266:273	arg1	properties					275:284	physical properties	266:284	physical properties	266:284	OBJECTIVE This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices.
33252063	4	50	from	environment	771:781	arg1	RESULTS					675:681	SULTS Porosity, swelling properties and in vitro degradation o	675:736	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment w	675:781	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	4	50	from	environment	771:781	arg1	Porosity					683:690	rosity, 	683:690	rosity, 	683:690	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	4	50	from	environment	771:781	arg1	degradation					726:736	 vitro degradation o	717:736	 vitro degradation o	717:736	SULTS Porosity, swelling properties and in vitro degradation of the microbeads in the aqueous environment were significantly changed by the added CaP. T
33252063	3	51	theme	various	554:560	arg1	CaP					562:564	various CaP	554:564	various CaP	554:564	METHODS Hybrid microbeads were successfully prepared from sodium alginate and various CaP, namely 𝛼-tricalcium phosphate, 𝛽-tricalcium phosphate and hydroxyapatite using the liquid droplet method. R
33252063	3	52	theme	liquid	652:657	arg1	method					667:672	e liquid droplet method. 	648:672	e liquid droplet method. 	648:672	METHODS Hybrid microbeads were successfully prepared from sodium alginate and various CaP, namely 𝛼-tricalcium phosphate, 𝛽-tricalcium phosphate and hydroxyapatite using the liquid droplet method. R
33252063	3	53	theme	Hybrid	484:489	arg1	microbeads					491:500	METHODS Hybrid microbeads	476:500	METHODS Hybrid microbeads	476:500	METHODS Hybrid microbeads were successfully prepared from sodium alginate and various CaP, namely 𝛼-tricalcium phosphate, 𝛽-tricalcium phosphate and hydroxyapatite using the liquid droplet method. R
33252063	5	54	theme	type	932:935	arg1	irrespective					912:923	respective o	912:923	respective o	912:923	e compressive strength of the blocks fabricated from the beads was around 120 MPa irrespective of the type of CaP. T
33252063	3	55	theme	droplet	659:665	arg1	method					667:672	e liquid droplet method. 	648:672	e liquid droplet method. 	648:672	METHODS Hybrid microbeads were successfully prepared from sodium alginate and various CaP, namely 𝛼-tricalcium phosphate, 𝛽-tricalcium phosphate and hydroxyapatite using the liquid droplet method. R
33252063	2	56	theme	microbeads	379:388	arg1	types					329:333	different types	319:333	different types	319:333	OBJECTIVE This study concerns the preparation, physical properties and in vitro characterisation of different types of alginate/calcium phosphate (CaP) ceramic microbeads, which were designed for use as drug delivery systems and bone-regeneration matrices.
33108322	1	0	theme	thermal	357:363	arg1	expansion					365:373	thermal expansion	357:373	thermal expansion	357:373	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	1	theme	restorative	269:279	arg1	materials					281:289	novel bone restorative materials	258:289	novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity	258:433	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	2	theme	expansion	365:373	arg1	bioactivity					423:433	bioactivity	423:433	bioactivity	423:433	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	2	theme	expansion	365:373	arg1	biocompatibility					402:417	biocompatibility	402:417	biocompatibility	402:417	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	2	theme	expansion	365:373	arg1	strength					392:399	high mechanical strength	376:399	high mechanical strength	376:399	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	2	theme	expansion	365:373	arg1	weight					330:335	light weight	324:335	light weight	324:335	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	2	theme	expansion	365:373	arg1	coefficient					342:352	low coefficient	338:352	low coefficient of thermal expansion	338:373	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	4	3	theme	low	886:888	arg1	crystallinity					890:902	extremely low crystallinity	876:902	extremely low crystallinity	876:902	As a result, the materials showed enough apatite-forming ability in a short time by mixing chitosan nanofibre and apatite nuclei with extremely low crystallinity and their high reactivity in simulated body fluid.
33108322	1	4	theme	high	180:183	arg1	ability					201:207	high apatite-forming ability	180:207	high apatite-forming ability	180:207	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	3	5	theme	simulated	720:728	arg1	fluid					735:739	simulated body fluid	720:739	simulated body fluid	720:739	In order to evaluate the bioactivity in vitro, the authors tested apatite-forming ability in simulated body fluid.
33108322	4	6	theme	apatite-forming	783:797	arg1	ability					799:805	enough apatite-forming ability	776:805	enough apatite-forming ability	776:805	As a result, the materials showed enough apatite-forming ability in a short time by mixing chitosan nanofibre and apatite nuclei with extremely low crystallinity and their high reactivity in simulated body fluid.
33108322	4	6	theme	apatite-forming	783:797	arg1	result					747:752	a result	745:752	a result	745:752	As a result, the materials showed enough apatite-forming ability in a short time by mixing chitosan nanofibre and apatite nuclei with extremely low crystallinity and their high reactivity in simulated body fluid.
33108322	1	7	theme	high	376:379	arg1	strength					392:399	high mechanical strength	376:399	high mechanical strength	376:399	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	8	theme	suitable	296:303	arg1	bioactivity					423:433	bioactivity	423:433	bioactivity	423:433	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	8	theme	suitable	296:303	arg1	coefficient					342:352	low coefficient	338:352	low coefficient of thermal expansion	338:373	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	8	theme	suitable	296:303	arg1	properties					305:314	suitable properties	296:314	suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity	296:433	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	8	theme	suitable	296:303	arg1	strength					392:399	high mechanical strength	376:399	high mechanical strength	376:399	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	8	theme	suitable	296:303	arg1	biocompatibility					402:417	biocompatibility	402:417	biocompatibility	402:417	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	8	theme	suitable	296:303	arg1	weight					330:335	light weight	324:335	light weight	324:335	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	9	theme	mechanical	381:390	arg1	strength					392:399	high mechanical strength	376:399	high mechanical strength	376:399	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	10	theme	apatite-forming	185:199	arg1	ability					201:207	high apatite-forming ability	180:207	high apatite-forming ability	180:207	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	4	11	theme	apatite	856:862	arg1	nuclei					864:869	apatite nuclei	856:869	apatite nuclei	856:869	As a result, the materials showed enough apatite-forming ability in a short time by mixing chitosan nanofibre and apatite nuclei with extremely low crystallinity and their high reactivity in simulated body fluid.
33108322	2	12	theme	reaction	518:525	arg1	time					527:530	the reaction time	514:530	the reaction time	514:530	In this study, the authors prepared three types of apatite nuclei by changing the reaction time aimed to optimise their crystallinity and fabricated their composites with chitosan nanofibre.
33108322	1	13	theme	Chitosan	87:94	arg1	composites					121:130	Chitosan nanofibre-apatite nuclei composites	87:130	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre	87:231	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	14	contain	possess	172:178	arg2	ability					201:207	high apatite-forming ability	180:207	high apatite-forming ability	180:207	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	14	contain	possess	172:178	arg1	nuclei					159:164	mixing apatite nuclei	144:164	mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre	144:231	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	4	15	from	crystallinity	890:902	arg1	fluid					948:952	simulated body fluid	933:952	simulated body fluid	933:952	As a result, the materials showed enough apatite-forming ability in a short time by mixing chitosan nanofibre and apatite nuclei with extremely low crystallinity and their high reactivity in simulated body fluid.
33108322	1	16	theme	nanofibre-apatite	96:112	arg1	composites					121:130	Chitosan nanofibre-apatite nuclei composites	87:130	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre	87:231	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	17	theme	chitosan	214:221	arg1	nanofibre					223:231	chitosan nanofibre	214:231	chitosan nanofibre	214:231	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	0	18	theme	ability	31:37	arg1	Impartation					0:10	Impartation	0:10	Impartation of apatite-forming ability to chitosan	0:49	Impartation of apatite-forming ability to chitosan nanofibres by using apatite nuclei.
33108322	1	19	theme	nuclei	114:119	arg1	composites					121:130	Chitosan nanofibre-apatite nuclei composites	87:130	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre	87:231	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	0	20	theme	apatite-forming	15:29	arg1	ability					31:37	apatite-forming ability	15:37	apatite-forming ability	15:37	Impartation of apatite-forming ability to chitosan nanofibres by using apatite nuclei.
33108322	4	21	theme	body	943:946	arg1	fluid					948:952	simulated body fluid	933:952	simulated body fluid	933:952	As a result, the materials showed enough apatite-forming ability in a short time by mixing chitosan nanofibre and apatite nuclei with extremely low crystallinity and their high reactivity in simulated body fluid.
33108322	2	22	theme	nuclei	495:500	arg1	types					478:482	three types	472:482	three types of apatite nuclei	472:500	In this study, the authors prepared three types of apatite nuclei by changing the reaction time aimed to optimise their crystallinity and fabricated their composites with chitosan nanofibre.
33108322	1	23	theme	light	324:328	arg1	weight					330:335	light weight	324:335	light weight	324:335	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	4	24	theme	chitosan	833:840	arg1	nanofibre					842:850	chitosan nanofibre	833:850	chitosan nanofibre	833:850	As a result, the materials showed enough apatite-forming ability in a short time by mixing chitosan nanofibre and apatite nuclei with extremely low crystallinity and their high reactivity in simulated body fluid.
33108322	2	25	theme	apatite	487:493	arg1	nuclei					495:500	apatite nuclei	487:500	apatite nuclei	487:500	In this study, the authors prepared three types of apatite nuclei by changing the reaction time aimed to optimise their crystallinity and fabricated their composites with chitosan nanofibre.
33108322	2	26	theme	chitosan	607:614	arg1	nanofibre					616:624	chitosan nanofibre	607:624	chitosan nanofibre	607:624	In this study, the authors prepared three types of apatite nuclei by changing the reaction time aimed to optimise their crystallinity and fabricated their composites with chitosan nanofibre.
33108322	1	27	theme	low	338:340	arg1	coefficient					342:352	low coefficient	338:352	low coefficient of thermal expansion	338:373	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	4	28	theme	high	914:917	arg1	reactivity					919:928	their high reactivity	908:928	their high reactivity in simulated body fluid	908:952	As a result, the materials showed enough apatite-forming ability in a short time by mixing chitosan nanofibre and apatite nuclei with extremely low crystallinity and their high reactivity in simulated body fluid.
33108322	3	29	theme	apatite-forming	693:707	arg1	ability					709:715	apatite-forming ability	693:715	apatite-forming ability	693:715	In order to evaluate the bioactivity in vitro, the authors tested apatite-forming ability in simulated body fluid.
33108322	4	30	theme	simulated	933:941	arg1	fluid					948:952	simulated body fluid	933:952	simulated body fluid	933:952	As a result, the materials showed enough apatite-forming ability in a short time by mixing chitosan nanofibre and apatite nuclei with extremely low crystallinity and their high reactivity in simulated body fluid.
33108322	4	31	theme	short	812:816	arg1	time					818:821	a short time	810:821	a short time	810:821	As a result, the materials showed enough apatite-forming ability in a short time by mixing chitosan nanofibre and apatite nuclei with extremely low crystallinity and their high reactivity in simulated body fluid.
33108322	1	32	with	materials	281:289	arg1	bioactivity					423:433	bioactivity	423:433	bioactivity	423:433	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	32	with	materials	281:289	arg1	coefficient					342:352	low coefficient	338:352	low coefficient of thermal expansion	338:373	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	32	with	materials	281:289	arg1	properties					305:314	suitable properties	296:314	suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity	296:433	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	32	with	materials	281:289	arg1	strength					392:399	high mechanical strength	376:399	high mechanical strength	376:399	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	32	with	materials	281:289	arg1	biocompatibility					402:417	biocompatibility	402:417	biocompatibility	402:417	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	32	with	materials	281:289	arg1	weight					330:335	light weight	324:335	light weight	324:335	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	1	33	theme	mixing	144:149	arg1	nuclei					159:164	mixing apatite nuclei	144:164	mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre	144:231	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	4	34	from	reactivity	919:928	arg1	fluid					948:952	simulated body fluid	933:952	simulated body fluid	933:952	As a result, the materials showed enough apatite-forming ability in a short time by mixing chitosan nanofibre and apatite nuclei with extremely low crystallinity and their high reactivity in simulated body fluid.
33108322	1	35	theme	apatite	151:157	arg1	nuclei					159:164	mixing apatite nuclei	144:164	mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre	144:231	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	0	36	theme	apatite	71:77	arg1	nuclei					79:84	apatite nuclei	71:84	apatite nuclei	71:84	Impartation of apatite-forming ability to chitosan nanofibres by using apatite nuclei.
33108322	1	37	theme	novel	258:262	arg1	materials					281:289	novel bone restorative materials	258:289	novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity	258:433	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33108322	3	38	theme	body	730:733	arg1	fluid					735:739	simulated body fluid	720:739	simulated body fluid	720:739	In order to evaluate the bioactivity in vitro, the authors tested apatite-forming ability in simulated body fluid.
33108322	1	39	theme	bone	264:267	arg1	materials					281:289	novel bone restorative materials	258:289	novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity	258:433	Chitosan nanofibre-apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity.
33464860	10	0	theme	scanning	1301:1308	arg1	microscopy					1319:1328	scanning electron microscopy	1301:1328	scanning electron microscopy	1301:1328	Further, the changes in the morphology of the material after functionalization were evaluated by scanning electron microscopy and atomic force microscopy.
33464860	8	1	theme	materials	1095:1103	arg1	composition					1076:1086	the elemental composition	1062:1086	the elemental composition of the materials	1062:1103	X-ray photoelectron spectroscopy was used to study the elemental composition of the materials.
33464860	8	2	theme	photoelectron	1017:1029	arg1	spectroscopy					1031:1042	X-ray photoelectron spectroscopy	1011:1042	X-ray photoelectron spectroscopy	1011:1042	X-ray photoelectron spectroscopy was used to study the elemental composition of the materials.
33464860	12	3	theme	Supporting	1505:1514	arg1	Information					1516:1526	the Supporting Information	1501:1526	the Supporting Information	1501:1526	A video is also provided in the Supporting Information to show the application potential of this material for developing leather-like materials.
33464860	7	4	theme	solid-state	923:933	arg1	spectroscopy					943:954	solid-state 13C NMR spectroscopy	923:954	solid-state 13C NMR spectroscopy	923:954	Particularly, the chemical structures of the materials were studied by solid-state 13C NMR spectroscopy and attenuated total reflection-infrared spectroscopy.
33464860	4	5	theme	dense	565:569	arg1	groups					580:585	dense aromatic groups	565:585	dense aromatic groups	565:585	By this methodology, dense aromatic groups have been incorporated for the improvement of hydrophobicity.
33464860	12	6	theme	application	1540:1550	arg1	potential					1552:1560	the application potential	1536:1560	the application potential of this material for developing leather-like materials	1536:1615	A video is also provided in the Supporting Information to show the application potential of this material for developing leather-like materials.
33464860	11	7	from	increase	1418:1425	arg1	hydrophobicity					1430:1443	hydrophobicity	1430:1443	hydrophobicity	1430:1443	Finally, water contact angle measurement revealed manyfold increase in hydrophobicity after click polymerization.
33464860	11	8	theme	water	1368:1372	arg1	measurement					1388:1398	water contact angle measurement	1368:1398	water contact angle measurement	1368:1398	Finally, water contact angle measurement revealed manyfold increase in hydrophobicity after click polymerization.
33464860	1	9	theme	-based	144:149	arg1	materials					151:159	bacterial cellulose (BC)-based materials	120:159	bacterial cellulose (BC)-based materials	120:159	The vast application potentials of bacterial cellulose (BC)-based materials for developing leather-like materials, wound-healing materials and electronic materials have been realized very recently.
33464860	9	10	theme	crystallite	1120:1130	arg1	changes					1132:1138	the crystallite changes	1116:1138	the crystallite changes of modified BC surfaces	1116:1162	Moreover, the crystallite changes of modified BC surfaces were investigated by X-ray diffraction.
33464860	5	11	theme	conventional	734:745	arg1	reactions					753:761	conventional click reactions	734:761	conventional click reactions	734:761	For comparative studies, various fluorine-based compounds have been introduced using conventional click reactions.
33464860	2	12	theme	properties	363:372	arg1	improvement					340:350	improvement	340:350	improvement of certain properties such as water repellency, mechanical strength,	340:419	Surface functionalization of these materials can help in improvement of certain properties such as water repellency, mechanical strength, and so forth.
33464860	3	13	theme	first	532:536	arg1	time					538:541	the first time	528:541	the first time	528:541	In this paper, we reported functionalization of BC surfaces using "click" polymerization for the first time.
33464860	5	14	theme	click	747:751	arg1	reactions					753:761	conventional click reactions	734:761	conventional click reactions	734:761	For comparative studies, various fluorine-based compounds have been introduced using conventional click reactions.
33464860	6	15	theme	spectroscopic	829:841	arg1	methods					843:849	various spectroscopic methods	821:849	various spectroscopic methods	821:849	The surface-modified BC materials have been confirmed by various spectroscopic methods.
33464860	4	16	theme	aromatic	571:578	arg1	groups					580:585	dense aromatic groups	565:585	dense aromatic groups	565:585	By this methodology, dense aromatic groups have been incorporated for the improvement of hydrophobicity.
33464860	3	17	theme	surfaces	486:493	arg1	functionalization					462:478	functionalization	462:478	functionalization of BC surfaces	462:493	In this paper, we reported functionalization of BC surfaces using "click" polymerization for the first time.
33464860	10	18	from	changes	1217:1223	arg1	morphology					1232:1241	the morphology	1228:1241	the morphology of the material after functionalization	1228:1281	Further, the changes in the morphology of the material after functionalization were evaluated by scanning electron microscopy and atomic force microscopy.
33464860	6	19	theme	various	821:827	arg1	methods					843:849	various spectroscopic methods	821:849	various spectroscopic methods	821:849	The surface-modified BC materials have been confirmed by various spectroscopic methods.
33464860	2	20	theme	Surface	283:289	arg1	functionalization					291:307	Surface functionalization	283:307	Surface functionalization of these materials	283:326	Surface functionalization of these materials can help in improvement of certain properties such as water repellency, mechanical strength, and so forth.
33464860	7	21	theme	materials	897:905	arg1	structures					879:888	the chemical structures	866:888	the chemical structures of the materials	866:905	Particularly, the chemical structures of the materials were studied by solid-state 13C NMR spectroscopy and attenuated total reflection-infrared spectroscopy.
33464860	1	22	theme	materials	151:159	arg1	materials					239:247	electronic materials	228:247	electronic materials	228:247	The vast application potentials of bacterial cellulose (BC)-based materials for developing leather-like materials, wound-healing materials and electronic materials have been realized very recently.
33464860	1	22	theme	materials	151:159	arg1	potentials					106:115	The vast application potentials	85:115	The vast application potentials of bacterial cellulose (BC)-based materials for developing leather-like materials	85:197	The vast application potentials of bacterial cellulose (BC)-based materials for developing leather-like materials, wound-healing materials and electronic materials have been realized very recently.
33464860	1	22	theme	materials	151:159	arg1	materials					214:222	wound-healing materials	200:222	wound-healing materials	200:222	The vast application potentials of bacterial cellulose (BC)-based materials for developing leather-like materials, wound-healing materials and electronic materials have been realized very recently.
33464860	11	23	theme	click	1451:1455	arg1	polymerization					1457:1470	click polymerization	1451:1470	click polymerization	1451:1470	Finally, water contact angle measurement revealed manyfold increase in hydrophobicity after click polymerization.
33464860	7	24	theme	reflection-infrared	977:995	arg1	spectroscopy					997:1008	attenuated total reflection-infrared spectroscopy	960:1008	attenuated total reflection-infrared spectroscopy	960:1008	Particularly, the chemical structures of the materials were studied by solid-state 13C NMR spectroscopy and attenuated total reflection-infrared spectroscopy.
33464860	9	25	theme	BC	1152:1153	arg1	surfaces					1155:1162	modified BC surfaces	1143:1162	modified BC surfaces	1143:1162	Moreover, the crystallite changes of modified BC surfaces were investigated by X-ray diffraction.
33464860	2	26	theme	mechanical	400:409	arg1	repellency					388:397	water repellency	382:397	water repellency	382:397	Surface functionalization of these materials can help in improvement of certain properties such as water repellency, mechanical strength, and so forth.
33464860	2	26	theme	mechanical	400:409	arg1	strength					411:418	mechanical strength	400:418	mechanical strength	400:418	Surface functionalization of these materials can help in improvement of certain properties such as water repellency, mechanical strength, and so forth.
33464860	11	27	theme	contact	1374:1380	arg1	measurement					1388:1398	water contact angle measurement	1368:1398	water contact angle measurement	1368:1398	Finally, water contact angle measurement revealed manyfold increase in hydrophobicity after click polymerization.
33464860	8	28	used	used	1048:1051	arg2	spectroscopy					1031:1042	X-ray photoelectron spectroscopy	1011:1042	X-ray photoelectron spectroscopy	1011:1042	X-ray photoelectron spectroscopy was used to study the elemental composition of the materials.
33464860	0	29	theme	Improved	0:7	arg1	Hydrophobicity					9:22	Improved Hydrophobicity	0:22	Improved Hydrophobicity of a Bacterial Cellulose Surface: Click Chemistry in Action.	0:83	Improved Hydrophobicity of a Bacterial Cellulose Surface: Click Chemistry in Action.
33464860	11	30	theme	angle	1382:1386	arg1	measurement					1388:1398	water contact angle measurement	1368:1398	water contact angle measurement	1368:1398	Finally, water contact angle measurement revealed manyfold increase in hydrophobicity after click polymerization.
33464860	7	31	theme	attenuated	960:969	arg1	spectroscopy					997:1008	attenuated total reflection-infrared spectroscopy	960:1008	attenuated total reflection-infrared spectroscopy	960:1008	Particularly, the chemical structures of the materials were studied by solid-state 13C NMR spectroscopy and attenuated total reflection-infrared spectroscopy.
33464860	1	32	theme	leather-like	176:187	arg1	materials					189:197	leather-like materials	176:197	leather-like materials	176:197	The vast application potentials of bacterial cellulose (BC)-based materials for developing leather-like materials, wound-healing materials and electronic materials have been realized very recently.
33464860	11	33	theme	manyfold	1409:1416	arg1	increase					1418:1425	manyfold increase	1409:1425	manyfold increase in hydrophobicity	1409:1443	Finally, water contact angle measurement revealed manyfold increase in hydrophobicity after click polymerization.
33464860	7	34	theme	total	971:975	arg1	spectroscopy					997:1008	attenuated total reflection-infrared spectroscopy	960:1008	attenuated total reflection-infrared spectroscopy	960:1008	Particularly, the chemical structures of the materials were studied by solid-state 13C NMR spectroscopy and attenuated total reflection-infrared spectroscopy.
33464860	2	35	theme	materials	318:326	arg1	functionalization					291:307	Surface functionalization	283:307	Surface functionalization of these materials	283:326	Surface functionalization of these materials can help in improvement of certain properties such as water repellency, mechanical strength, and so forth.
33464860	7	36	theme	chemical	870:877	arg1	structures					879:888	the chemical structures	866:888	the chemical structures of the materials	866:905	Particularly, the chemical structures of the materials were studied by solid-state 13C NMR spectroscopy and attenuated total reflection-infrared spectroscopy.
33464860	9	37	theme	surfaces	1155:1162	arg1	changes					1132:1138	the crystallite changes	1116:1138	the crystallite changes of modified BC surfaces	1116:1162	Moreover, the crystallite changes of modified BC surfaces were investigated by X-ray diffraction.
33464860	6	38	theme	surface-modified	768:783	arg1	materials					788:796	The surface-modified BC materials	764:796	The surface-modified BC materials	764:796	The surface-modified BC materials have been confirmed by various spectroscopic methods.
33464860	1	39	theme	application	94:104	arg1	potentials					106:115	The vast application potentials	85:115	The vast application potentials of bacterial cellulose (BC)-based materials for developing leather-like materials	85:197	The vast application potentials of bacterial cellulose (BC)-based materials for developing leather-like materials, wound-healing materials and electronic materials have been realized very recently.
33464860	2	40	theme	water	382:386	arg1	repellency					388:397	water repellency	382:397	water repellency	382:397	Surface functionalization of these materials can help in improvement of certain properties such as water repellency, mechanical strength, and so forth.
33464860	2	40	theme	water	382:386	arg1	strength					411:418	mechanical strength	400:418	mechanical strength	400:418	Surface functionalization of these materials can help in improvement of certain properties such as water repellency, mechanical strength, and so forth.
33464860	0	41	theme	Cellulose	39:47	arg1	Surface					49:55	a Bacterial Cellulose Surface	27:55	a Bacterial Cellulose Surface	27:55	Improved Hydrophobicity of a Bacterial Cellulose Surface: Click Chemistry in Action.
33464860	9	42	theme	modified	1143:1150	arg1	surfaces					1155:1162	modified BC surfaces	1143:1162	modified BC surfaces	1143:1162	Moreover, the crystallite changes of modified BC surfaces were investigated by X-ray diffraction.
33464860	4	43	theme	hydrophobicity	633:646	arg1	improvement					618:628	the improvement	614:628	the improvement of hydrophobicity	614:646	By this methodology, dense aromatic groups have been incorporated for the improvement of hydrophobicity.
33464860	9	44	theme	X-ray	1185:1189	arg1	diffraction					1191:1201	X-ray diffraction	1185:1201	X-ray diffraction	1185:1201	Moreover, the crystallite changes of modified BC surfaces were investigated by X-ray diffraction.
33464860	1	45	theme	wound-healing	200:212	arg1	materials					214:222	wound-healing materials	200:222	wound-healing materials	200:222	The vast application potentials of bacterial cellulose (BC)-based materials for developing leather-like materials, wound-healing materials and electronic materials have been realized very recently.
33464860	0	46	theme	Bacterial	29:37	arg1	Surface					49:55	a Bacterial Cellulose Surface	27:55	a Bacterial Cellulose Surface	27:55	Improved Hydrophobicity of a Bacterial Cellulose Surface: Click Chemistry in Action.
33464860	0	47	from	Chemistry	64:72	arg1	Action					77:82	Action	77:82	Action	77:82	Improved Hydrophobicity of a Bacterial Cellulose Surface: Click Chemistry in Action.
33464860	6	48	theme	BC	785:786	arg1	materials					788:796	The surface-modified BC materials	764:796	The surface-modified BC materials	764:796	The surface-modified BC materials have been confirmed by various spectroscopic methods.
33464860	2	49	theme	certain	355:361	arg1	repellency					388:397	water repellency	382:397	water repellency	382:397	Surface functionalization of these materials can help in improvement of certain properties such as water repellency, mechanical strength, and so forth.
33464860	2	49	theme	certain	355:361	arg1	properties					363:372	certain properties	355:372	certain properties such as water repellency, mechanical strength,	355:419	Surface functionalization of these materials can help in improvement of certain properties such as water repellency, mechanical strength, and so forth.
33464860	0	50	theme	Surface	49:55	arg1	Hydrophobicity					9:22	Improved Hydrophobicity	0:22	Improved Hydrophobicity of a Bacterial Cellulose Surface: Click Chemistry in Action.	0:83	Improved Hydrophobicity of a Bacterial Cellulose Surface: Click Chemistry in Action.
33464860	5	51	theme	various	674:680	arg1	compounds					697:705	various fluorine-based compounds	674:705	various fluorine-based compounds	674:705	For comparative studies, various fluorine-based compounds have been introduced using conventional click reactions.
33464860	12	52	theme	material	1570:1577	arg1	potential					1552:1560	the application potential	1536:1560	the application potential of this material for developing leather-like materials	1536:1615	A video is also provided in the Supporting Information to show the application potential of this material for developing leather-like materials.
33464860	3	53	theme	click	502:506	arg1	polymerization					509:522	"click" polymerization	501:522	"click" polymerization	501:522	In this paper, we reported functionalization of BC surfaces using "click" polymerization for the first time.
33464860	5	54	theme	comparative	653:663	arg1	studies					665:671	comparative studies	653:671	comparative studies	653:671	For comparative studies, various fluorine-based compounds have been introduced using conventional click reactions.
33464860	5	55	theme	fluorine-based	682:695	arg1	compounds					697:705	various fluorine-based compounds	674:705	various fluorine-based compounds	674:705	For comparative studies, various fluorine-based compounds have been introduced using conventional click reactions.
33464860	8	56	theme	elemental	1066:1074	arg1	composition					1076:1086	the elemental composition	1062:1086	the elemental composition of the materials	1062:1103	X-ray photoelectron spectroscopy was used to study the elemental composition of the materials.
33464860	10	57	theme	electron	1310:1317	arg1	microscopy					1319:1328	scanning electron microscopy	1301:1328	scanning electron microscopy	1301:1328	Further, the changes in the morphology of the material after functionalization were evaluated by scanning electron microscopy and atomic force microscopy.
33464860	1	58	theme	bacterial	120:128	arg1	materials					151:159	bacterial cellulose (BC)-based materials	120:159	bacterial cellulose (BC)-based materials	120:159	The vast application potentials of bacterial cellulose (BC)-based materials for developing leather-like materials, wound-healing materials and electronic materials have been realized very recently.
33464860	1	59	theme	vast	89:92	arg1	potentials					106:115	The vast application potentials	85:115	The vast application potentials of bacterial cellulose (BC)-based materials for developing leather-like materials	85:197	The vast application potentials of bacterial cellulose (BC)-based materials for developing leather-like materials, wound-healing materials and electronic materials have been realized very recently.
33464860	10	60	theme	atomic	1334:1339	arg1	microscopy					1347:1356	atomic force microscopy	1334:1356	atomic force microscopy	1334:1356	Further, the changes in the morphology of the material after functionalization were evaluated by scanning electron microscopy and atomic force microscopy.
33464860	12	61	theme	leather-like	1594:1605	arg1	materials					1607:1615	leather-like materials	1594:1615	leather-like materials	1594:1615	A video is also provided in the Supporting Information to show the application potential of this material for developing leather-like materials.
33464860	8	62	theme	X-ray	1011:1015	arg1	spectroscopy					1031:1042	X-ray photoelectron spectroscopy	1011:1042	X-ray photoelectron spectroscopy	1011:1042	X-ray photoelectron spectroscopy was used to study the elemental composition of the materials.
33464860	3	63	theme	BC	483:484	arg1	surfaces					486:493	BC surfaces	483:493	BC surfaces	483:493	In this paper, we reported functionalization of BC surfaces using "click" polymerization for the first time.
33464860	7	64	theme	13C	935:937	arg1	spectroscopy					943:954	solid-state 13C NMR spectroscopy	923:954	solid-state 13C NMR spectroscopy	923:954	Particularly, the chemical structures of the materials were studied by solid-state 13C NMR spectroscopy and attenuated total reflection-infrared spectroscopy.
33464860	1	65	theme	electronic	228:237	arg1	materials					239:247	electronic materials	228:247	electronic materials	228:247	The vast application potentials of bacterial cellulose (BC)-based materials for developing leather-like materials, wound-healing materials and electronic materials have been realized very recently.
33464860	0	66	dep	Hydrophobicity	9:22	arg1	Chemistry					64:72	Click Chemistry	58:72	Improved Hydrophobicity of a Bacterial Cellulose Surface: Click Chemistry in Action.	0:83	Improved Hydrophobicity of a Bacterial Cellulose Surface: Click Chemistry in Action.
33464860	3	67	theme	"	507:507	arg1	polymerization					509:522	"click" polymerization	501:522	"click" polymerization	501:522	In this paper, we reported functionalization of BC surfaces using "click" polymerization for the first time.
33464860	7	68	theme	NMR	939:941	arg1	spectroscopy					943:954	solid-state 13C NMR spectroscopy	923:954	solid-state 13C NMR spectroscopy	923:954	Particularly, the chemical structures of the materials were studied by solid-state 13C NMR spectroscopy and attenuated total reflection-infrared spectroscopy.
33464860	0	69	theme	Click	58:62	arg1	Chemistry					64:72	Click Chemistry	58:72	Improved Hydrophobicity of a Bacterial Cellulose Surface: Click Chemistry in Action.	0:83	Improved Hydrophobicity of a Bacterial Cellulose Surface: Click Chemistry in Action.
33464860	10	70	theme	material	1250:1257	arg1	morphology					1232:1241	the morphology	1228:1241	the morphology of the material after functionalization	1228:1281	Further, the changes in the morphology of the material after functionalization were evaluated by scanning electron microscopy and atomic force microscopy.
33464860	10	71	theme	force	1341:1345	arg1	microscopy					1347:1356	atomic force microscopy	1334:1356	atomic force microscopy	1334:1356	Further, the changes in the morphology of the material after functionalization were evaluated by scanning electron microscopy and atomic force microscopy.
33872123	5	0	with	hour	994:997	arg1	solution					1032:1039	the bisulfite solution	1018:1039	the bisulfite solution	1018:1039	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	13	1	theme	activities	2489:2498	arg1	implication					2456:2466	the effective implication	2442:2466	the effective implication of numerous economic activities	2442:2498	Therefore, this method will ascertain the effective implication of numerous economic activities.
33872123	1	2	theme	starch	232:237	arg1	amount					214:219	a significant amount	200:219	a significant amount of natural starch	200:237	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	1	2	theme	starch	232:237	arg1	starch					232:237	natural starch	224:237	natural starch	224:237	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	7	3	theme	Zetasizer	1435:1443	arg1	test					1445:1448	Malvern Zetasizer test	1427:1448	Malvern Zetasizer test	1427:1448	Malvern Zetasizer test revealed a bimodal granular distribution for starch, with 7.15 µm of hydrodynamic size.
33872123	4	4	theme	starch	879:884	arg1	synthesis					886:894	starch synthesis	879:894	starch synthesis	879:894	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	10	5	theme	trunk	1915:1919	arg1	tons					1898:1901	110 million tons	1886:1901	110 million tons of palm oil trunk (OPT)	1886:1925	About 110 million tons of palm oil trunk (OPT) biomass is available annually during replanting activities.
33872123	5	6	theme	%	1171:1171	arg1	solution					1183:1190	0.74% bisulfite solution	1167:1190	0.74% bisulfite solution	1167:1190	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	6	theme	%	1171:1171	arg1	hours					1206:1210	5.6 steeping hours	1193:1210	5.6 steeping hours	1193:1210	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	10	7	theme	palm	1906:1909	arg1	trunk					1915:1919	palm oil trunk	1906:1919	palm oil trunk (OPT)	1906:1925	About 110 million tons of palm oil trunk (OPT) biomass is available annually during replanting activities.
33872123	3	8	theme	bisulfite	533:541	arg1	effectiveness					512:524	the effectiveness	508:524	the effectiveness of the bisulfite	508:541	This study investigated the effectiveness of the bisulfite steeping method for starch synthesis from oil palm trunk (OPT) biowaste.
33872123	1	9	theme	oil	164:166	arg1	biomass					180:186	Elaeis guineensis (oil palm) trunk biomass	145:186	Elaeis guineensis (oil palm) trunk biomass	145:186	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	4	10	theme	bisulfite	849:857	arg1	method					868:873	the bisulfite steeping method	845:873	the bisulfite steeping method for starch synthesis	845:894	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	13	11	theme	numerous	2471:2478	arg1	activities					2489:2498	numerous economic activities	2471:2498	numerous economic activities	2471:2498	Therefore, this method will ascertain the effective implication of numerous economic activities.
33872123	4	12	theme	central	620:626	arg1	CCD					646:648	CCD	646:648	CCD	646:648	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	4	12	theme	central	620:626	arg1	design					638:643	The central composite design	616:643	The central composite design (CCD) of Design-Expert	616:666	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	3	13	theme	starch	563:568	arg1	synthesis					570:578	starch synthesis	563:578	starch synthesis	563:578	This study investigated the effectiveness of the bisulfite steeping method for starch synthesis from oil palm trunk (OPT) biowaste.
33872123	1	14	theme	biomass	180:186	arg1	available					243:251	available	243:251	available	243:251	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	1	14	theme	biomass	180:186	arg1	quantity					133:140	A massive quantity	123:140	A massive quantity	123:140	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	11	15	theme	beneficial	2021:2030	arg1	form					2032:2035	a beneficial form	2019:2035	a beneficial form (only 22% presently)	2019:2056	Modification of bio-wastes into a beneficial form (only 22% presently) like starch extraction would ensure potential reuse as a natural coagulant for wastewater and leachate treatment, food source, adhesives towards boosting the country's economy by sustainable waste management.
33872123	12	16	theme	better	2294:2299	arg1	yield					2308:2312	better starch yield	2294:2312	better starch yield (13.54%)	2294:2321	The current study achieved better starch yield (13.54%) than previous, from the OPT biomass through the novel bisulfite steeping method.
33872123	12	16	theme	better	2294:2299	arg1	%					2320:2320	13.54%	2315:2320	13.54%	2315:2320	The current study achieved better starch yield (13.54%) than previous, from the OPT biomass through the novel bisulfite steeping method.
33872123	11	17	theme	waste	2249:2253	arg1	management					2255:2264	sustainable waste management	2237:2264	sustainable waste management	2237:2264	Modification of bio-wastes into a beneficial form (only 22% presently) like starch extraction would ensure potential reuse as a natural coagulant for wastewater and leachate treatment, food source, adhesives towards boosting the country's economy by sustainable waste management.
33872123	6	18	with	consistent	1331:1340	arg1	model					1361:1365	the predicted model	1347:1365	the predicted model	1347:1365	Experimental outcomes were consistent with the predicted model, which eventually sustains the significance of this method.
33872123	0	19	from	biomass	57:63	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of natural starch from Elaeis guineensis trunk biomass	0:63	Synthesis of natural starch from Elaeis guineensis trunk biomass applying bisulphite steeping method: Optimization by RSM.
33872123	3	20	theme	palm	589:592	arg1	trunk					594:598	oil palm trunk	585:598	oil palm trunk (OPT) biowaste	585:613	This study investigated the effectiveness of the bisulfite steeping method for starch synthesis from oil palm trunk (OPT) biowaste.
33872123	4	21	dep	model	702:706	arg1	evaluated					731:739	evaluated	731:739	evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis	731:894	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	1	22	theme	massive	125:131	arg1	available					243:251	available	243:251	available	243:251	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	1	22	theme	massive	125:131	arg1	quantity					133:140	A massive quantity	123:140	A massive quantity	123:140	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	11	23	theme	starch	2063:2068	arg1	extraction					2070:2079	starch extraction	2063:2079	starch extraction	2063:2079	Modification of bio-wastes into a beneficial form (only 22% presently) like starch extraction would ensure potential reuse as a natural coagulant for wastewater and leachate treatment, food source, adhesives towards boosting the country's economy by sustainable waste management.
33872123	9	24	theme	hydroxyl	1737:1744	arg1	presence					1725:1732	the presence	1721:1732	the presence of hydroxyl, carboxylic, and phenolic groups	1721:1777	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	5	25	theme	mixing	1229:1234	arg1	ratio					1236:1240	1.6 and 0.6 mixing ratio	1217:1240	1.6 and 0.6 mixing ratio	1217:1240	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	9	26	theme	carboxylic	1747:1756	arg1	presence					1725:1732	the presence	1721:1732	the presence of hydroxyl, carboxylic, and phenolic groups	1721:1777	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	5	27	dep	factors	937:943	arg1	strength					946:953	strength	946:953	strength of sodium bisulfite solution	946:982	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	27	dep	factors	937:943	arg1	factors					937:943	four factors	932:943	four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water)	932:1061	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	27	dep	factors	937:943	arg1	water					1056:1060	ultrapure water	1046:1060	ultrapure water	1046:1060	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	27	dep	factors	937:943	arg1	hour					994:997	steeping hour	985:997	steeping hour	985:997	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	27	dep	factors	937:943	arg1	ratio					1007:1011	mixing ratio	1000:1011	mixing ratio with the bisulfite solution	1000:1039	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	0	28	theme	bisulphite	74:83	arg1	method					94:99	bisulphite steeping method	74:99	bisulphite steeping method	74:99	Synthesis of natural starch from Elaeis guineensis trunk biomass applying bisulphite steeping method: Optimization by RSM.
33872123	1	29	theme	guineensis	152:161	arg1	biomass					180:186	Elaeis guineensis (oil palm) trunk biomass	145:186	Elaeis guineensis (oil palm) trunk biomass	145:186	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	7	30	theme	size	1532:1535	arg1	7.15 µm					1508:1514	7.15 µm	1508:1514	7.15 µm of hydrodynamic size	1508:1535	Malvern Zetasizer test revealed a bimodal granular distribution for starch, with 7.15 µm of hydrodynamic size.
33872123	6	31	theme	Experimental	1304:1315	arg1	outcomes					1317:1324	Experimental outcomes	1304:1324	Experimental outcomes	1304:1324	Experimental outcomes were consistent with the predicted model, which eventually sustains the significance of this method.
33872123	5	32	theme	bisulfite	965:973	arg1	solution					975:982	sodium bisulfite solution	958:982	sodium bisulfite solution	958:982	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	9	33	theme	groups	1772:1777	arg1	presence					1725:1732	the presence	1721:1732	the presence of hydroxyl, carboxylic, and phenolic groups	1721:1777	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	4	34	theme	process	756:762	arg1	variables					764:772	process variables	756:772	process variables	756:772	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	5	35	theme	%	1081:1081	arg1	response					1071:1078	one response	1067:1078	one response (%Yield)	1067:1087	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	35	theme	%	1081:1081	arg1	Yield					1082:1086	%Yield	1081:1086	%Yield	1081:1086	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	9	36	theme	other	1784:1788	arg1	starches.Implications					1797:1817	other cereal starches.Implications	1784:1817	other cereal starches.Implications	1784:1817	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	2	37	theme	carbohydrate	350:361	arg1	polymer					363:369	this starch (carbohydrate polymer)	337:370	this starch (carbohydrate polymer)	337:370	The efficient extraction of this starch (carbohydrate polymer) would be worthwhile concerning the environmental sustainability and economy through conversion to bioresources.
33872123	13	38	theme	effective	2446:2454	arg1	implication					2456:2466	the effective implication	2442:2466	the effective implication of numerous economic activities	2442:2498	Therefore, this method will ascertain the effective implication of numerous economic activities.
33872123	2	39	theme	environmental	407:419	arg1	sustainability					421:434	the environmental sustainability	403:434	the environmental sustainability	403:434	The efficient extraction of this starch (carbohydrate polymer) would be worthwhile concerning the environmental sustainability and economy through conversion to bioresources.
33872123	12	40	theme	novel	2371:2375	arg1	method					2396:2401	the novel bisulfite steeping method	2367:2401	the novel bisulfite steeping method	2367:2401	The current study achieved better starch yield (13.54%) than previous, from the OPT biomass through the novel bisulfite steeping method.
33872123	0	41	theme	natural	13:19	arg1	starch					21:26	natural starch	13:26	natural starch	13:26	Synthesis of natural starch from Elaeis guineensis trunk biomass applying bisulphite steeping method: Optimization by RSM.
33872123	11	42	theme	leachate	2152:2159	arg1	treatment					2161:2169	leachate treatment	2152:2169	leachate treatment	2152:2169	Modification of bio-wastes into a beneficial form (only 22% presently) like starch extraction would ensure potential reuse as a natural coagulant for wastewater and leachate treatment, food source, adhesives towards boosting the country's economy by sustainable waste management.
33872123	12	43	theme	steeping	2387:2394	arg1	method					2396:2401	the novel bisulfite steeping method	2367:2401	the novel bisulfite steeping method	2367:2401	The current study achieved better starch yield (13.54%) than previous, from the OPT biomass through the novel bisulfite steeping method.
33872123	4	44	theme	response	804:811	arg1	methodology					821:831	response surface methodology	804:831	response surface methodology	804:831	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	5	45	theme	bisulfite	1251:1259	arg1	solution					1261:1268	the bisulfite solution	1247:1268	the bisulfite solution	1247:1268	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	46	theme	significant	1109:1119	arg1	yield					1128:1132	a significant starch yield	1107:1132	a significant starch yield (13.54%)	1107:1141	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	46	theme	significant	1109:1119	arg1	%					1140:1140	13.54%	1135:1140	13.54%	1135:1140	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	46	theme	significant	1109:1119	arg1	achievable					1146:1155	achievable	1146:1155	achievable	1146:1155	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	46	theme	significant	1109:1119	arg1	employing					1157:1165	employing	1157:1165	employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively	1157:1301	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	12	47	theme	OPT	2347:2349	arg1	biomass					2351:2357	the OPT biomass	2343:2357	the OPT biomass through the novel bisulfite steeping method	2343:2401	The current study achieved better starch yield (13.54%) than previous, from the OPT biomass through the novel bisulfite steeping method.
33872123	11	48	theme	potential	2094:2102	arg1	reuse					2104:2108	potential reuse	2094:2108	potential reuse	2094:2108	Modification of bio-wastes into a beneficial form (only 22% presently) like starch extraction would ensure potential reuse as a natural coagulant for wastewater and leachate treatment, food source, adhesives towards boosting the country's economy by sustainable waste management.
33872123	2	49	theme	efficient	313:321	arg1	worthwhile					381:390	worthwhile	381:390	worthwhile	381:390	The efficient extraction of this starch (carbohydrate polymer) would be worthwhile concerning the environmental sustainability and economy through conversion to bioresources.
33872123	2	49	theme	efficient	313:321	arg1	extraction					323:332	The efficient extraction	309:332	The efficient extraction of this starch (carbohydrate polymer)	309:370	The efficient extraction of this starch (carbohydrate polymer) would be worthwhile concerning the environmental sustainability and economy through conversion to bioresources.
33872123	6	50	theme	predicted	1351:1359	arg1	model					1361:1365	the predicted model	1347:1365	the predicted model	1347:1365	Experimental outcomes were consistent with the predicted model, which eventually sustains the significance of this method.
33872123	7	51	theme	granular	1469:1476	arg1	distribution					1478:1489	a bimodal granular distribution	1459:1489	a bimodal granular distribution for starch	1459:1500	Malvern Zetasizer test revealed a bimodal granular distribution for starch, with 7.15 µm of hydrodynamic size.
33872123	5	52	theme	bisulfite	1022:1030	arg1	solution					1032:1039	the bisulfite solution	1018:1039	the bisulfite solution	1018:1039	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	9	53	theme	largest	1840:1846	arg1	exporter					1857:1864	the 2nd largest palm oil exporter	1832:1864	the 2nd largest palm oil exporter in the world	1832:1877	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	9	53	theme	largest	1840:1846	arg1	Malaysia					1820:1827	Malaysia	1820:1827	Malaysia	1820:1827	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	9	54	theme	diffraction	1610:1620	arg1	investigation					1622:1634	X-ray diffraction investigation	1604:1634	X-ray diffraction investigation	1604:1634	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	5	55	theme	bisulfite	1173:1181	arg1	solution					1183:1190	0.74% bisulfite solution	1167:1190	0.74% bisulfite solution	1167:1190	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	55	theme	bisulfite	1173:1181	arg1	hours					1206:1210	5.6 steeping hours	1193:1210	5.6 steeping hours	1193:1210	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	9	56	theme	oil	1853:1855	arg1	exporter					1857:1864	the 2nd largest palm oil exporter	1832:1864	the 2nd largest palm oil exporter in the world	1832:1877	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	9	56	theme	oil	1853:1855	arg1	Malaysia					1820:1827	Malaysia	1820:1827	Malaysia	1820:1827	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	4	57	theme	interaction	784:794	arg1	impacts					745:751	the impacts	741:751	the impacts of process variables and their interaction through response surface methodology	741:831	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	2	58	theme	starch	342:347	arg1	polymer					363:369	this starch (carbohydrate polymer)	337:370	this starch (carbohydrate polymer)	337:370	The efficient extraction of this starch (carbohydrate polymer) would be worthwhile concerning the environmental sustainability and economy through conversion to bioresources.
33872123	5	59	theme	mixing	1000:1005	arg1	factors					937:943	four factors	932:943	four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water)	932:1061	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	59	theme	mixing	1000:1005	arg1	ratio					1007:1011	mixing ratio	1000:1011	mixing ratio with the bisulfite solution	1000:1039	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	8	60	theme	scanning	1574:1581	arg1	microscopy					1592:1601	scanning electron microscopy	1574:1601	scanning electron microscopy	1574:1601	Starch morphology was determined by scanning electron microscopy.
33872123	10	61	theme	million	1890:1896	arg1	tons					1898:1901	110 million tons	1886:1901	110 million tons of palm oil trunk (OPT)	1886:1925	About 110 million tons of palm oil trunk (OPT) biomass is available annually during replanting activities.
33872123	13	62	theme	economic	2480:2487	arg1	activities					2489:2498	numerous economic activities	2471:2498	numerous economic activities	2471:2498	Therefore, this method will ascertain the effective implication of numerous economic activities.
33872123	5	63	with	solution	1183:1190	arg1	solution					1261:1268	the bisulfite solution	1247:1268	the bisulfite solution	1247:1268	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	63	with	solution	1183:1190	arg1	water					1284:1288	ultrapure water	1274:1288	ultrapure water	1274:1288	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	6	64	theme	method	1419:1424	arg1	significance					1398:1409	the significance	1394:1409	the significance of this method	1394:1424	Experimental outcomes were consistent with the predicted model, which eventually sustains the significance of this method.
33872123	1	65	theme	natural	224:230	arg1	starch					232:237	natural starch	224:237	natural starch	224:237	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	7	66	theme	Malvern	1427:1433	arg1	test					1445:1448	Malvern Zetasizer test	1427:1448	Malvern Zetasizer test	1427:1448	Malvern Zetasizer test revealed a bimodal granular distribution for starch, with 7.15 µm of hydrodynamic size.
33872123	4	67	theme	steeping	859:866	arg1	method					868:873	the bisulfite steeping method	845:873	the bisulfite steeping method for starch synthesis	845:894	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	5	68	theme	0.74	1167:1170	arg1	%					1171:1171	%	1171:1171	%	1171:1171	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	9	69	theme	A-type	1648:1653	arg1	model					1655:1659	an A-type model	1645:1659	an A-type model	1645:1659	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	5	70	with	ratio	1007:1011	arg1	solution					1032:1039	the bisulfite solution	1018:1039	the bisulfite solution	1018:1039	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	10	71	theme	oil	1911:1913	arg1	trunk					1915:1919	palm oil trunk	1906:1919	palm oil trunk (OPT)	1906:1925	About 110 million tons of palm oil trunk (OPT) biomass is available annually during replanting activities.
33872123	1	72	from	Malaysia	256:263	arg1	available					243:251	available	243:251	available	243:251	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	1	72	from	Malaysia	256:263	arg1	quantity					133:140	A massive quantity	123:140	A massive quantity	123:140	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	1	73	theme	palm	168:171	arg1	biomass					180:186	Elaeis guineensis (oil palm) trunk biomass	145:186	Elaeis guineensis (oil palm) trunk biomass	145:186	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	0	74	theme	guineensis	40:49	arg1	biomass					57:63	Elaeis guineensis trunk biomass	33:63	Elaeis guineensis trunk biomass	33:63	Synthesis of natural starch from Elaeis guineensis trunk biomass applying bisulphite steeping method: Optimization by RSM.
33872123	5	75	with	strength	946:953	arg1	solution					1032:1039	the bisulfite solution	1018:1039	the bisulfite solution	1018:1039	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	1	76	from	available	243:251	arg1	Malaysia					256:263	Malaysia	256:263	Malaysia	256:263	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	3	77	dep	trunk	594:598	arg1	OPT					601:603	OPT	601:603	OPT	601:603	This study investigated the effectiveness of the bisulfite steeping method for starch synthesis from oil palm trunk (OPT) biowaste.
33872123	9	78	theme	persistent	1673:1682	arg1	characteristics					1684:1698	persistent characteristics	1673:1698	persistent characteristics	1673:1698	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	9	79	from	exporter	1857:1864	arg1	world					1873:1877	the world	1869:1877	the world	1869:1877	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	1	80	theme	trunk	174:178	arg1	biomass					180:186	Elaeis guineensis (oil palm) trunk biomass	145:186	Elaeis guineensis (oil palm) trunk biomass	145:186	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	12	81	theme	starch	2301:2306	arg1	yield					2308:2312	better starch yield	2294:2312	better starch yield (13.54%)	2294:2321	The current study achieved better starch yield (13.54%) than previous, from the OPT biomass through the novel bisulfite steeping method.
33872123	12	81	theme	starch	2301:2306	arg1	%					2320:2320	13.54%	2315:2320	13.54%	2315:2320	The current study achieved better starch yield (13.54%) than previous, from the OPT biomass through the novel bisulfite steeping method.
33872123	5	82	theme	developed	901:909	arg1	models					921:926	The developed quadratic models	897:926	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield)	897:1087	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	11	83	theme	sustainable	2237:2247	arg1	management					2255:2264	sustainable waste management	2237:2264	sustainable waste management	2237:2264	Modification of bio-wastes into a beneficial form (only 22% presently) like starch extraction would ensure potential reuse as a natural coagulant for wastewater and leachate treatment, food source, adhesives towards boosting the country's economy by sustainable waste management.
33872123	3	84	theme	trunk	594:598	arg1	biowaste					606:613	oil palm trunk (OPT) biowaste	585:613	oil palm trunk (OPT) biowaste	585:613	This study investigated the effectiveness of the bisulfite steeping method for starch synthesis from oil palm trunk (OPT) biowaste.
33872123	4	85	theme	composite	628:636	arg1	CCD					646:648	CCD	646:648	CCD	646:648	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	4	85	theme	composite	628:636	arg1	design					638:643	The central composite design	616:643	The central composite design (CCD) of Design-Expert	616:666	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	3	86	theme	oil	585:587	arg1	trunk					594:598	oil palm trunk	585:598	oil palm trunk (OPT) biowaste	585:613	This study investigated the effectiveness of the bisulfite steeping method for starch synthesis from oil palm trunk (OPT) biowaste.
33872123	5	87	theme	quadratic	911:919	arg1	models					921:926	The developed quadratic models	897:926	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield)	897:1087	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	12	88	theme	current	2271:2277	arg1	study					2279:2283	The current study	2267:2283	The current study	2267:2283	The current study achieved better starch yield (13.54%) than previous, from the OPT biomass through the novel bisulfite steeping method.
33872123	4	89	theme	experimental	689:700	arg1	model					702:706	an experimental model	686:706	an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis	686:894	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	5	90	dep	achievable	1146:1155	arg1	yield					1128:1132	a significant starch yield	1107:1132	a significant starch yield (13.54%)	1107:1141	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	90	dep	achievable	1146:1155	arg1	achievable					1146:1155	achievable	1146:1155	achievable	1146:1155	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	90	dep	achievable	1146:1155	arg1	employing					1157:1165	employing	1157:1165	employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively	1157:1301	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	91	theme	ultrapure	1046:1054	arg1	factors					937:943	four factors	932:943	four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water)	932:1061	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	91	theme	ultrapure	1046:1054	arg1	water					1056:1060	ultrapure water	1046:1060	ultrapure water	1046:1060	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	4	92	theme	Design-Expert	654:666	arg1	CCD					646:648	CCD	646:648	CCD	646:648	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	4	92	theme	Design-Expert	654:666	arg1	design					638:643	The central composite design	616:643	The central composite design (CCD) of Design-Expert	616:666	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	5	93	theme	steeping	1197:1204	arg1	solution					1183:1190	0.74% bisulfite solution	1167:1190	0.74% bisulfite solution	1167:1190	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	93	theme	steeping	1197:1204	arg1	hours					1206:1210	5.6 steeping hours	1193:1210	5.6 steeping hours	1193:1210	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	10	94	theme	replanting	1964:1973	arg1	activities					1975:1984	replanting activities	1964:1984	replanting activities	1964:1984	About 110 million tons of palm oil trunk (OPT) biomass is available annually during replanting activities.
33872123	0	95	theme	steeping	85:92	arg1	method					94:99	bisulphite steeping method	74:99	bisulphite steeping method	74:99	Synthesis of natural starch from Elaeis guineensis trunk biomass applying bisulphite steeping method: Optimization by RSM.
33872123	1	96	theme	Elaeis	145:150	arg1	biomass					180:186	Elaeis guineensis (oil palm) trunk biomass	145:186	Elaeis guineensis (oil palm) trunk biomass	145:186	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	7	97	theme	hydrodynamic	1519:1530	arg1	size					1532:1535	hydrodynamic size	1519:1535	hydrodynamic size	1519:1535	Malvern Zetasizer test revealed a bimodal granular distribution for starch, with 7.15 µm of hydrodynamic size.
33872123	11	98	theme	food	2172:2175	arg1	source					2177:2182	food source	2172:2182	food source	2172:2182	Modification of bio-wastes into a beneficial form (only 22% presently) like starch extraction would ensure potential reuse as a natural coagulant for wastewater and leachate treatment, food source, adhesives towards boosting the country's economy by sustainable waste management.
33872123	11	98	theme	food	2172:2175	arg1	coagulant					2123:2131	a natural coagulant	2113:2131	a natural coagulant for wastewater and leachate treatment	2113:2169	Modification of bio-wastes into a beneficial form (only 22% presently) like starch extraction would ensure potential reuse as a natural coagulant for wastewater and leachate treatment, food source, adhesives towards boosting the country's economy by sustainable waste management.
33872123	5	99	theme	sodium	958:963	arg1	solution					975:982	sodium bisulfite solution	958:982	sodium bisulfite solution	958:982	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	11	100	theme	bio-wastes	2003:2012	arg1	Modification					1987:1998	Modification	1987:1998	Modification of bio-wastes into a beneficial form (only 22% presently) like starch extraction	1987:2079	Modification of bio-wastes into a beneficial form (only 22% presently) like starch extraction would ensure potential reuse as a natural coagulant for wastewater and leachate treatment, food source, adhesives towards boosting the country's economy by sustainable waste management.
33872123	9	101	theme	phenolic	1763:1770	arg1	groups					1772:1777	phenolic groups	1763:1777	phenolic groups	1763:1777	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	4	102	dep	software	668:675	arg1	executed					677:684	executed	677:684	software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis	668:894	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	5	103	theme	ultrapure	1274:1282	arg1	water					1284:1288	ultrapure water	1274:1288	ultrapure water	1274:1288	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	2	104	theme	polymer	363:369	arg1	worthwhile					381:390	worthwhile	381:390	worthwhile	381:390	The efficient extraction of this starch (carbohydrate polymer) would be worthwhile concerning the environmental sustainability and economy through conversion to bioresources.
33872123	2	104	theme	polymer	363:369	arg1	extraction					323:332	The efficient extraction	309:332	The efficient extraction of this starch (carbohydrate polymer)	309:370	The efficient extraction of this starch (carbohydrate polymer) would be worthwhile concerning the environmental sustainability and economy through conversion to bioresources.
33872123	9	105	theme	cereal	1790:1795	arg1	starches.Implications					1797:1817	other cereal starches.Implications	1784:1817	other cereal starches.Implications	1784:1817	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	12	106	theme	bisulfite	2377:2385	arg1	method					2396:2401	the novel bisulfite steeping method	2367:2401	the novel bisulfite steeping method	2367:2401	The current study achieved better starch yield (13.54%) than previous, from the OPT biomass through the novel bisulfite steeping method.
33872123	4	107	theme	data	716:719	arg1	design					708:713	design	708:713	design	708:713	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	4	107	theme	data	716:719	arg1	analysis					721:728	data analysis	716:728	data analysis	716:728	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	0	108	theme	starch	21:26	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of natural starch from Elaeis guineensis trunk biomass	0:63	Synthesis of natural starch from Elaeis guineensis trunk biomass applying bisulphite steeping method: Optimization by RSM.
33872123	0	109	dep	applying	65:72	arg1	Optimization					102:113	Optimization	102:113	Optimization by RSM	102:120	Synthesis of natural starch from Elaeis guineensis trunk biomass applying bisulphite steeping method: Optimization by RSM.
33872123	11	110	theme	natural	2115:2121	arg1	coagulant					2123:2131	a natural coagulant	2113:2131	a natural coagulant for wastewater and leachate treatment	2113:2169	Modification of bio-wastes into a beneficial form (only 22% presently) like starch extraction would ensure potential reuse as a natural coagulant for wastewater and leachate treatment, food source, adhesives towards boosting the country's economy by sustainable waste management.
33872123	11	110	theme	natural	2115:2121	arg1	source					2177:2182	food source	2172:2182	food source	2172:2182	Modification of bio-wastes into a beneficial form (only 22% presently) like starch extraction would ensure potential reuse as a natural coagulant for wastewater and leachate treatment, food source, adhesives towards boosting the country's economy by sustainable waste management.
33872123	10	111	dep	trunk	1915:1919	arg1	OPT					1922:1924	OPT	1922:1924	OPT	1922:1924	About 110 million tons of palm oil trunk (OPT) biomass is available annually during replanting activities.
33872123	5	112	theme	solution	975:982	arg1	strength					946:953	strength	946:953	strength of sodium bisulfite solution	946:982	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	112	theme	solution	975:982	arg1	factors					937:943	four factors	932:943	four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water)	932:1061	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	112	theme	solution	975:982	arg1	ratio					1007:1011	mixing ratio	1000:1011	mixing ratio with the bisulfite solution	1000:1039	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	112	theme	solution	975:982	arg1	water					1056:1060	ultrapure water	1046:1060	ultrapure water	1046:1060	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	112	theme	solution	975:982	arg1	hour					994:997	steeping hour	985:997	steeping hour	985:997	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	113	with	water	1056:1060	arg1	solution					1032:1039	the bisulfite solution	1018:1039	the bisulfite solution	1018:1039	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	0	114	theme	Elaeis	33:38	arg1	biomass					57:63	Elaeis guineensis trunk biomass	33:63	Elaeis guineensis trunk biomass	33:63	Synthesis of natural starch from Elaeis guineensis trunk biomass applying bisulphite steeping method: Optimization by RSM.
33872123	8	115	theme	Starch	1538:1543	arg1	morphology					1545:1554	Starch morphology	1538:1554	Starch morphology	1538:1554	Starch morphology was determined by scanning electron microscopy.
33872123	0	116	theme	trunk	51:55	arg1	biomass					57:63	Elaeis guineensis trunk biomass	33:63	Elaeis guineensis trunk biomass	33:63	Synthesis of natural starch from Elaeis guineensis trunk biomass applying bisulphite steeping method: Optimization by RSM.
33872123	5	117	theme	starch	1121:1126	arg1	yield					1128:1132	a significant starch yield	1107:1132	a significant starch yield (13.54%)	1107:1141	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	117	theme	starch	1121:1126	arg1	%					1140:1140	13.54%	1135:1140	13.54%	1135:1140	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	117	theme	starch	1121:1126	arg1	achievable					1146:1155	achievable	1146:1155	achievable	1146:1155	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	117	theme	starch	1121:1126	arg1	employing					1157:1165	employing	1157:1165	employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively	1157:1301	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	9	118	theme	2nd	1836:1838	arg1	exporter					1857:1864	the 2nd largest palm oil exporter	1832:1864	the 2nd largest palm oil exporter in the world	1832:1877	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	9	118	theme	2nd	1836:1838	arg1	Malaysia					1820:1827	Malaysia	1820:1827	Malaysia	1820:1827	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	1	119	contain	containing	189:198	arg2	starch					232:237	natural starch	224:237	natural starch	224:237	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	1	119	contain	containing	189:198	arg1	available					243:251	available	243:251	available	243:251	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	1	119	contain	containing	189:198	arg1	quantity					133:140	A massive quantity	123:140	A massive quantity	123:140	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	1	119	contain	containing	189:198	arg2	amount					214:219	a significant amount	200:219	a significant amount of natural starch	200:237	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	4	120	theme	surface	813:819	arg1	methodology					821:831	response surface methodology	804:831	response surface methodology	804:831	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	1	121	theme	annual	288:293	arg1	replantation					295:306	annual replantation	288:306	annual replantation	288:306	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	5	122	theme	steeping	985:992	arg1	factors					937:943	four factors	932:943	four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water)	932:1061	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	5	122	theme	steeping	985:992	arg1	hour					994:997	steeping hour	985:997	steeping hour	985:997	The developed quadratic models for four factors (strength of sodium bisulfite solution, steeping hour, mixing ratio with the bisulfite solution, and ultrapure water) and one response (%Yield) demonstrated that a significant starch yield (13.54%) is achievable employing 0.74% bisulfite solution, 5.6 steeping hours, for 1.6 and 0.6 mixing ratio with the bisulfite solution and ultrapure water respectively.
33872123	9	123	theme	palm	1848:1851	arg1	exporter					1857:1864	the 2nd largest palm oil exporter	1832:1864	the 2nd largest palm oil exporter in the world	1832:1877	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	9	123	theme	palm	1848:1851	arg1	Malaysia					1820:1827	Malaysia	1820:1827	Malaysia	1820:1827	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	4	124	theme	variables	764:772	arg1	impacts					745:751	the impacts	741:751	the impacts of process variables and their interaction through response surface methodology	741:831	The central composite design (CCD) of Design-Expert software executed an experimental model design, data analysis, evaluated the impacts of process variables and their interaction through response surface methodology to optimize the bisulfite steeping method for starch synthesis.
33872123	1	125	theme	significant	202:212	arg1	amount					214:219	a significant amount	200:219	a significant amount of natural starch	200:237	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	1	125	theme	significant	202:212	arg1	starch					232:237	natural starch	224:237	natural starch	224:237	A massive quantity of Elaeis guineensis (oil palm) trunk biomass, containing a significant amount of natural starch, is available in Malaysia as biowaste because of annual replantation.
33872123	7	126	theme	bimodal	1461:1467	arg1	distribution					1478:1489	a bimodal granular distribution	1459:1489	a bimodal granular distribution for starch	1459:1500	Malvern Zetasizer test revealed a bimodal granular distribution for starch, with 7.15 µm of hydrodynamic size.
33872123	9	127	theme	X-ray	1604:1608	arg1	diffraction					1610:1620	X-ray diffraction	1604:1620	X-ray diffraction investigation	1604:1634	X-ray diffraction investigation exhibits an A-type model, specifying persistent characteristics, while FTIR confirms the presence of hydroxyl, carboxylic, and phenolic groups like other cereal starches.Implications: Malaysia is the 2nd largest palm oil exporter in the world.
33872123	8	128	theme	electron	1583:1590	arg1	microscopy					1592:1601	scanning electron microscopy	1574:1601	scanning electron microscopy	1574:1601	Starch morphology was determined by scanning electron microscopy.
33872123	11	129	dep	form	2032:2035	arg1	%					2045:2045	only 22%	2038:2045	only 22% presently	2038:2055	Modification of bio-wastes into a beneficial form (only 22% presently) like starch extraction would ensure potential reuse as a natural coagulant for wastewater and leachate treatment, food source, adhesives towards boosting the country's economy by sustainable waste management.
32399597	0	0	theme	Capsule	97:103	arg1	Types					105:109	Different Capsule Types	87:109	Different Capsule Types	87:109	Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions.
32399597	7	1	theme	gelatin	1224:1230	arg1	capsules					1232:1239	the gelatin capsules	1220:1239	the gelatin capsules (Quali-G™-I)	1220:1252	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	7	1	theme	gelatin	1224:1230	arg1	Quali-G™-I					1242:1251	Quali-G™-I	1242:1251	Quali-G™-I	1242:1251	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	1	2	theme	powder	185:190	arg1	DPI					201:203	DPI	201:203	DPI	201:203	Capsule-based dry powder inhaler (DPI) products can be influenced by a multitude of interacting factors, including electrostatic charging.
32399597	1	2	theme	powder	185:190	arg1	inhaler					192:198	Capsule-based dry powder inhaler	167:198	Capsule-based dry powder inhaler (DPI) products	167:213	Capsule-based dry powder inhaler (DPI) products can be influenced by a multitude of interacting factors, including electrostatic charging.
32399597	1	3	theme	factors	263:269	arg1	multitude					238:246	a multitude	236:246	a multitude of interacting factors, including electrostatic charging	236:303	Capsule-based dry powder inhaler (DPI) products can be influenced by a multitude of interacting factors, including electrostatic charging.
32399597	0	4	theme	Different	87:95	arg1	Types					105:109	Different Capsule Types	87:109	Different Capsule Types	87:109	Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions.
32399597	1	5	theme	inhaler	192:198	arg1	products					206:213	Capsule-based dry powder inhaler (DPI) products	167:213	Capsule-based dry powder inhaler (DPI) products	167:213	Capsule-based dry powder inhaler (DPI) products can be influenced by a multitude of interacting factors, including electrostatic charging.
32399597	8	6	from	humidities	1372:1381	arg1	sorption					1316:1323	The sorption	1312:1323	The sorption of water by the capsules at different relative humidities	1312:1381	The sorption of water by the capsules at different relative humidities notably impacted their properties and tribo-charging behavior.
32399597	7	7	theme	Vcaps®	1187:1192	arg1	capsules					1177:1184	the thermally gelled HPMC capsules	1151:1184	the thermally gelled HPMC capsules (Vcaps® Plus)	1151:1198	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	7	7	theme	Vcaps®	1187:1192	arg1	Plus					1194:1197	Vcaps® Plus	1187:1197	Vcaps® Plus	1187:1197	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	4	8	theme	different	664:672	arg1	gelatin					697:703	gelatin	697:703	gelatin	697:703	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	8	theme	different	664:672	arg1	methylcellulose					723:737	hydroxypropyl methylcellulose	709:737	hydroxypropyl methylcellulose (HPMC)	709:744	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	8	theme	different	664:672	arg1	compositions					683:694	different chemical compositions	664:694	different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC))	664:745	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	9	9	theme	charging	1580:1587	arg1	behaviors					1589:1597	distinct charging behaviors	1571:1597	distinct charging behaviors	1571:1597	Different interactions between the tested materials and water molecules were identified and are proposed to be the driver of distinct charging behaviors.
32399597	9	10	theme	Different	1446:1454	arg1	driver					1561:1566	the driver	1557:1566	the driver of distinct charging behaviors	1557:1597	Different interactions between the tested materials and water molecules were identified and are proposed to be the driver of distinct charging behaviors.
32399597	9	10	theme	Different	1446:1454	arg1	interactions					1456:1467	Different interactions	1446:1467	Different interactions between the tested materials and water molecules	1446:1516	Different interactions between the tested materials and water molecules were identified and are proposed to be the driver of distinct charging behaviors.
32399597	0	11	theme	Types	105:109	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of the Physico-mechanical Properties	0:46	Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions.
32399597	0	11	theme	Types	105:109	arg1	Behavior					75:82	Electrostatic Charging Behavior	52:82	Electrostatic Charging Behavior	52:82	Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions.
32399597	9	12	theme	distinct	1571:1578	arg1	behaviors					1589:1597	distinct charging behaviors	1571:1597	distinct charging behaviors	1571:1597	Different interactions between the tested materials and water molecules were identified and are proposed to be the driver of distinct charging behaviors.
32399597	10	13	theme	capsule	1641:1647	arg1	types					1649:1653	the capsule types	1637:1653	the capsule types	1637:1653	Finally, we showed that depending on the capsule types, distinct environmental conditions are necessary to mitigate charging and assure optimal behavior of the capsules.
32399597	4	14	theme	distinct	751:758	arg1	characteristics					769:783	distinct inherent characteristics	751:783	distinct inherent characteristics	751:783	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	1	15	theme	electrostatic	282:294	arg1	charging					296:303	electrostatic charging	282:303	electrostatic charging	282:303	Capsule-based dry powder inhaler (DPI) products can be influenced by a multitude of interacting factors, including electrostatic charging.
32399597	9	16	theme	water	1502:1506	arg1	molecules					1508:1516	water molecules	1502:1516	water molecules	1502:1516	Different interactions between the tested materials and water molecules were identified and are proposed to be the driver of distinct charging behaviors.
32399597	8	17	theme	different	1353:1361	arg1	humidities					1372:1381	different relative humidities	1353:1381	different relative humidities	1353:1381	The sorption of water by the capsules at different relative humidities notably impacted their properties and tribo-charging behavior.
32399597	9	18	theme	tested	1481:1486	arg1	materials					1488:1496	the tested materials	1477:1496	the tested materials	1477:1496	Different interactions between the tested materials and water molecules were identified and are proposed to be the driver of distinct charging behaviors.
32399597	7	19	theme	HPMC	1172:1175	arg1	capsules					1177:1184	the thermally gelled HPMC capsules	1151:1184	the thermally gelled HPMC capsules (Vcaps® Plus)	1151:1198	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	7	19	theme	HPMC	1172:1175	arg1	Plus					1194:1197	Vcaps® Plus	1187:1197	Vcaps® Plus	1187:1197	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	5	20	dep	stainless	999:1007	arg1	stainless					999:1007	stainless steel and PVC	999:1021	stainless steel and PVC	999:1021	Their resulting properties were characterized and tribo-charging behavior was measured against stainless steel and PVC.
32399597	5	20	dep	stainless	999:1007	arg1	PVC					1019:1021	PVC	1019:1021	PVC	1019:1021	Their resulting properties were characterized and tribo-charging behavior was measured against stainless steel and PVC.
32399597	5	20	dep	stainless	999:1007	arg1	steel					1009:1013	steel	1009:1013	steel	1009:1013	Their resulting properties were characterized and tribo-charging behavior was measured against stainless steel and PVC.
32399597	3	21	theme	capsules	566:573	arg1	behavior					554:561	the charging behavior	541:561	the charging behavior of capsules intended for inhalation	541:597	Consequently, this work aimed to assess how the charging behavior of capsules intended for inhalation might be influenced by environmental conditions.
32399597	4	22	theme	hydroxypropyl	709:721	arg1	methylcellulose					723:737	hydroxypropyl methylcellulose	709:737	hydroxypropyl methylcellulose (HPMC)	709:744	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	22	theme	hydroxypropyl	709:721	arg1	compositions					683:694	different chemical compositions	664:694	different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC))	664:745	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	22	theme	hydroxypropyl	709:721	arg1	HPMC					740:743	HPMC	740:743	HPMC	740:743	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	2	23	theme	charge	337:342	arg1	transfer					344:351	charge transfer	337:351	charge transfer impacted by various factors, i.e., material surface characteristics, mechanical properties, processing parameters and environmental conditions	337:494	Tribo-charging is a process of charge transfer impacted by various factors, i.e., material surface characteristics, mechanical properties, processing parameters and environmental conditions.
32399597	7	24	theme	cold-gelled	1273:1283	arg1	Quali-V®-I					1299:1308	Quali-V®-I	1299:1308	Quali-V®-I	1299:1308	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	7	24	theme	cold-gelled	1273:1283	arg1	counterparts					1285:1296	their HPMC cold-gelled counterparts	1262:1296	their HPMC cold-gelled counterparts (Quali-V®-I)	1262:1309	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	2	25	theme	surface	397:403	arg1	characteristics					405:419	material surface characteristics	388:419	material surface characteristics	388:419	Tribo-charging is a process of charge transfer impacted by various factors, i.e., material surface characteristics, mechanical properties, processing parameters and environmental conditions.
32399597	2	26	theme	environmental	471:483	arg1	conditions					485:494	environmental conditions	471:494	environmental conditions	471:494	Tribo-charging is a process of charge transfer impacted by various factors, i.e., material surface characteristics, mechanical properties, processing parameters and environmental conditions.
32399597	8	27	theme	relative	1363:1370	arg1	humidities					1372:1381	different relative humidities	1353:1381	different relative humidities	1353:1381	The sorption of water by the capsules at different relative humidities notably impacted their properties and tribo-charging behavior.
32399597	2	28	theme	material	388:395	arg1	characteristics					405:419	material surface characteristics	388:419	material surface characteristics	388:419	Tribo-charging is a process of charge transfer impacted by various factors, i.e., material surface characteristics, mechanical properties, processing parameters and environmental conditions.
32399597	0	29	theme	Physico-mechanical	18:35	arg1	Properties					37:46	the Physico-mechanical Properties	14:46	the Physico-mechanical Properties	14:46	Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions.
32399597	0	30	theme	Environmental	141:153	arg1	Conditions					155:164	Distinct Environmental Conditions	132:164	Distinct Environmental Conditions	132:164	Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions.
32399597	4	31	dep	compositions	683:694	arg1	gelatin					697:703	gelatin	697:703	gelatin	697:703	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	31	dep	compositions	683:694	arg1	methylcellulose					723:737	hydroxypropyl methylcellulose	709:737	hydroxypropyl methylcellulose (HPMC)	709:744	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	31	dep	compositions	683:694	arg1	compositions					683:694	different chemical compositions	664:694	different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC))	664:745	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	31	dep	compositions	683:694	arg1	HPMC					740:743	HPMC	740:743	HPMC	740:743	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	2	32	theme	processing	445:454	arg1	parameters					456:465	processing parameters	445:465	processing parameters	445:465	Tribo-charging is a process of charge transfer impacted by various factors, i.e., material surface characteristics, mechanical properties, processing parameters and environmental conditions.
32399597	0	33	theme	Distinct	132:139	arg1	Conditions					155:164	Distinct Environmental Conditions	132:164	Distinct Environmental Conditions	132:164	Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions.
32399597	8	34	theme	water	1328:1332	arg1	sorption					1316:1323	The sorption	1312:1323	The sorption of water by the capsules at different relative humidities	1312:1381	The sorption of water by the capsules at different relative humidities notably impacted their properties and tribo-charging behavior.
32399597	3	35	theme	charging	545:552	arg1	behavior					554:561	the charging behavior	541:561	the charging behavior of capsules intended for inhalation	541:597	Consequently, this work aimed to assess how the charging behavior of capsules intended for inhalation might be influenced by environmental conditions.
32399597	7	36	theme	capsules	1177:1184	arg1	similar					1209:1215	similar	1209:1215	similar	1209:1215	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	7	36	theme	capsules	1177:1184	arg1	tribo-charging					1133:1146	The tribo-charging	1129:1146	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus)	1129:1198	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	5	37	theme	tribo-charging	954:967	arg1	behavior					969:976	tribo-charging behavior	954:976	tribo-charging behavior	954:976	Their resulting properties were characterized and tribo-charging behavior was measured against stainless steel and PVC.
32399597	10	38	theme	distinct	1656:1663	arg1	conditions					1679:1688	distinct environmental conditions	1656:1688	distinct environmental conditions	1656:1688	Finally, we showed that depending on the capsule types, distinct environmental conditions are necessary to mitigate charging and assure optimal behavior of the capsules.
32399597	0	39	theme	Properties	37:46	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of the Physico-mechanical Properties	0:46	Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions.
32399597	0	39	theme	Properties	37:46	arg1	Behavior					75:82	Electrostatic Charging Behavior	52:82	Electrostatic Charging Behavior	52:82	Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions.
32399597	6	40	with	contact	1111:1117	arg1	PVC					1124:1126	PVC	1124:1126	PVC	1124:1126	It was observed that all capsule materials tended to charge to a higher extent when in contact with PVC.
32399597	6	41	theme	capsule	1049:1055	arg1	materials					1057:1065	all capsule materials	1045:1065	all capsule materials	1045:1065	It was observed that all capsule materials tended to charge to a higher extent when in contact with PVC.
32399597	2	42	theme	mechanical	422:431	arg1	properties					433:442	mechanical properties	422:442	mechanical properties	422:442	Tribo-charging is a process of charge transfer impacted by various factors, i.e., material surface characteristics, mechanical properties, processing parameters and environmental conditions.
32399597	0	43	theme	Charging	66:73	arg1	Behavior					75:82	Electrostatic Charging Behavior	52:82	Electrostatic Charging Behavior	52:82	Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions.
32399597	5	44	theme	resulting	910:918	arg1	properties					920:929	Their resulting properties	904:929	Their resulting properties	904:929	Their resulting properties were characterized and tribo-charging behavior was measured against stainless steel and PVC.
32399597	8	45	theme	tribo-charging	1421:1434	arg1	behavior					1436:1443	tribo-charging behavior	1421:1443	tribo-charging behavior	1421:1443	The sorption of water by the capsules at different relative humidities notably impacted their properties and tribo-charging behavior.
32399597	2	46	theme	various	365:371	arg1	factors					373:379	various factors	365:379	various factors	365:379	Tribo-charging is a process of charge transfer impacted by various factors, i.e., material surface characteristics, mechanical properties, processing parameters and environmental conditions.
32399597	0	47	theme	Electrostatic	52:64	arg1	Behavior					75:82	Electrostatic Charging Behavior	52:82	Electrostatic Charging Behavior	52:82	Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions.
32399597	3	48	theme	environmental	622:634	arg1	conditions					636:645	environmental conditions	622:645	environmental conditions	622:645	Consequently, this work aimed to assess how the charging behavior of capsules intended for inhalation might be influenced by environmental conditions.
32399597	4	49	theme	inherent	760:767	arg1	characteristics					769:783	distinct inherent characteristics	751:783	distinct inherent characteristics	751:783	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	50	contain	having	657:662	arg2	compositions					683:694	different chemical compositions	664:694	different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC))	664:745	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	50	contain	having	657:662	arg2	characteristics					769:783	distinct inherent characteristics	751:783	distinct inherent characteristics	751:783	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	50	contain	having	657:662	arg2	methylcellulose					723:737	hydroxypropyl methylcellulose	709:737	hydroxypropyl methylcellulose (HPMC)	709:744	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	50	contain	having	657:662	arg1	Capsules					648:655	Capsules	648:655	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled)	648:830	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	50	contain	having	657:662	arg2	gelatin					697:703	gelatin	697:703	gelatin	697:703	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	51	theme	environmental	856:868	arg1	conditions					870:879	various environmental conditions	848:879	various environmental conditions (11%, 22% and 51% RH)	848:901	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	7	52	theme	HPMC	1268:1271	arg1	Quali-V®-I					1299:1308	Quali-V®-I	1299:1308	Quali-V®-I	1299:1308	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	7	52	theme	HPMC	1268:1271	arg1	counterparts					1285:1296	their HPMC cold-gelled counterparts	1262:1296	their HPMC cold-gelled counterparts (Quali-V®-I)	1262:1309	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	9	53	theme	behaviors	1589:1597	arg1	interactions					1456:1467	Different interactions	1446:1467	Different interactions between the tested materials and water molecules	1446:1516	Different interactions between the tested materials and water molecules were identified and are proposed to be the driver of distinct charging behaviors.
32399597	9	53	theme	behaviors	1589:1597	arg1	driver					1561:1566	the driver	1557:1566	the driver of distinct charging behaviors	1557:1597	Different interactions between the tested materials and water molecules were identified and are proposed to be the driver of distinct charging behaviors.
32399597	4	54	dep	having	657:662	arg1	cold-gelled					819:829	cold-gelled	819:829	cold-gelled	819:829	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	54	dep	having	657:662	arg1	thermally					805:813	thermally	805:813	thermally	805:813	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	55	theme	various	848:854	arg1	conditions					870:879	various environmental conditions	848:879	various environmental conditions (11%, 22% and 51% RH)	848:901	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	2	56	theme	transfer	344:351	arg1	Tribo-charging					306:319	Tribo-charging	306:319	Tribo-charging	306:319	Tribo-charging is a process of charge transfer impacted by various factors, i.e., material surface characteristics, mechanical properties, processing parameters and environmental conditions.
32399597	2	56	theme	transfer	344:351	arg1	process					326:332	a process	324:332	a process of charge transfer impacted by various factors, i.e., material surface characteristics, mechanical properties, processing parameters and environmental conditions	324:494	Tribo-charging is a process of charge transfer impacted by various factors, i.e., material surface characteristics, mechanical properties, processing parameters and environmental conditions.
32399597	10	57	theme	optimal	1736:1742	arg1	behavior of					1744:1754	optimal behavior of	1736:1754	optimal behavior of	1736:1754	Finally, we showed that depending on the capsule types, distinct environmental conditions are necessary to mitigate charging and assure optimal behavior of the capsules.
32399597	10	58	theme	environmental	1665:1677	arg1	conditions					1679:1688	distinct environmental conditions	1656:1688	distinct environmental conditions	1656:1688	Finally, we showed that depending on the capsule types, distinct environmental conditions are necessary to mitigate charging and assure optimal behavior of the capsules.
32399597	6	59	theme	higher	1089:1094	arg1	extent					1096:1101	a higher extent	1087:1101	a higher extent	1087:1101	It was observed that all capsule materials tended to charge to a higher extent when in contact with PVC.
32399597	1	60	theme	Capsule-based	167:179	arg1	DPI					201:203	DPI	201:203	DPI	201:203	Capsule-based dry powder inhaler (DPI) products can be influenced by a multitude of interacting factors, including electrostatic charging.
32399597	1	60	theme	Capsule-based	167:179	arg1	inhaler					192:198	Capsule-based dry powder inhaler	167:198	Capsule-based dry powder inhaler (DPI) products	167:213	Capsule-based dry powder inhaler (DPI) products can be influenced by a multitude of interacting factors, including electrostatic charging.
32399597	4	61	dep	conditions	870:879	arg1	%					884:884	11%	882:884	11%	882:884	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	61	dep	conditions	870:879	arg1	%					889:889	22%	887:889	22%	887:889	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	61	dep	conditions	870:879	arg1	%					897:897	51% RH	895:900	51% RH	895:900	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	62	theme	chemical	674:681	arg1	gelatin					697:703	gelatin	697:703	gelatin	697:703	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	62	theme	chemical	674:681	arg1	methylcellulose					723:737	hydroxypropyl methylcellulose	709:737	hydroxypropyl methylcellulose (HPMC)	709:744	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	4	62	theme	chemical	674:681	arg1	compositions					683:694	different chemical compositions	664:694	different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC))	664:745	Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH).
32399597	7	63	theme	gelled	1165:1170	arg1	capsules					1177:1184	the thermally gelled HPMC capsules	1151:1184	the thermally gelled HPMC capsules (Vcaps® Plus)	1151:1198	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	7	63	theme	gelled	1165:1170	arg1	Plus					1194:1197	Vcaps® Plus	1187:1197	Vcaps® Plus	1187:1197	The tribo-charging of the thermally gelled HPMC capsules (Vcaps® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V®-I).
32399597	2	64	dep	characteristics	405:419	arg1	i.e.					382:385	i.e.	382:385	i.e.	382:385	Tribo-charging is a process of charge transfer impacted by various factors, i.e., material surface characteristics, mechanical properties, processing parameters and environmental conditions.
32399597	1	65	theme	dry	181:183	arg1	DPI					201:203	DPI	201:203	DPI	201:203	Capsule-based dry powder inhaler (DPI) products can be influenced by a multitude of interacting factors, including electrostatic charging.
32399597	1	65	theme	dry	181:183	arg1	inhaler					192:198	Capsule-based dry powder inhaler	167:198	Capsule-based dry powder inhaler (DPI) products	167:213	Capsule-based dry powder inhaler (DPI) products can be influenced by a multitude of interacting factors, including electrostatic charging.
32399597	1	66	theme	interacting	251:261	arg1	charging					296:303	electrostatic charging	282:303	electrostatic charging	282:303	Capsule-based dry powder inhaler (DPI) products can be influenced by a multitude of interacting factors, including electrostatic charging.
32399597	1	66	theme	interacting	251:261	arg1	factors					263:269	interacting factors	251:269	interacting factors	251:269	Capsule-based dry powder inhaler (DPI) products can be influenced by a multitude of interacting factors, including electrostatic charging.
33493986	4	0	theme	DHHA	881:884	arg1	dehydrogenase					886:898	a DHHA dehydrogenase	879:898	a DHHA dehydrogenase	879:898	Previous studies showed that the ring A moiety is derived from chorismate, which is converted to 3-hydroxyanthranilic acid (3-HAA) by a 2-amino-2-deoxyisochorismate (ADIC) synthase, a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase, and a DHHA dehydrogenase.
33493986	4	1	attach	derived	686:692	arg2	moiety					676:681	the ring A moiety	665:681	the ring A moiety	665:681	Previous studies showed that the ring A moiety is derived from chorismate, which is converted to 3-hydroxyanthranilic acid (3-HAA) by a 2-amino-2-deoxyisochorismate (ADIC) synthase, a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase, and a DHHA dehydrogenase.
33493986	4	1	attach	derived	686:692	arg1	chorismate					699:708	chorismate	699:708	chorismate	699:708	Previous studies showed that the ring A moiety is derived from chorismate, which is converted to 3-hydroxyanthranilic acid (3-HAA) by a 2-amino-2-deoxyisochorismate (ADIC) synthase, a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase, and a DHHA dehydrogenase.
33493986	1	2	theme	attractive	168:177	arg1	activities					193:202	attractive antibacterial activities	168:202	attractive antibacterial activities against Gram-positive bacteria	168:233	Paulomycins (PAUs) refer to a group of glycosylated antibiotics with attractive antibacterial activities against Gram-positive bacteria.
33493986	6	3	theme	PAUs	1276:1279	arg1	moiety					1266:1271	the ring A moiety	1255:1271	the ring A moiety of PAUs	1255:1279	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	0	4	dep	6-hydroxylase	48:60	arg1	involved					62:69	involved	62:69	6-hydroxylase involved in paulomycin biosynthesis	48:96	Characterization of a 3-hydroxyanthranilic acid 6-hydroxylase involved in paulomycin biosynthesis.
33493986	1	5	with	antibiotics	151:161	arg1	activities					193:202	attractive antibacterial activities	168:202	attractive antibacterial activities against Gram-positive bacteria	168:233	Paulomycins (PAUs) refer to a group of glycosylated antibiotics with attractive antibacterial activities against Gram-positive bacteria.
33493986	4	6	theme	2-amino-2-deoxyisochorismate	772:799	arg1	synthase					808:815	a 2-amino-2-deoxyisochorismate (ADIC) synthase	770:815	a 2-amino-2-deoxyisochorismate (ADIC) synthase	770:815	Previous studies showed that the ring A moiety is derived from chorismate, which is converted to 3-hydroxyanthranilic acid (3-HAA) by a 2-amino-2-deoxyisochorismate (ADIC) synthase, a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase, and a DHHA dehydrogenase.
33493986	3	7	theme	moiety	490:495	arg1	mechanism					466:474	the biosynthetic mechanism	449:474	the biosynthetic mechanism of the ring A moiety	449:495	Elucidation of the biosynthetic mechanism of the ring A moiety may facilitate its structure modifications by combinatorial biosynthesis to generate PAU analogues with enhanced bioactivity or stability.
33493986	4	8	theme	3-hydroxyanthranilic	733:752	arg1	3-HAA					760:764	3-HAA	760:764	3-HAA	760:764	Previous studies showed that the ring A moiety is derived from chorismate, which is converted to 3-hydroxyanthranilic acid (3-HAA) by a 2-amino-2-deoxyisochorismate (ADIC) synthase, a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase, and a DHHA dehydrogenase.
33493986	4	8	theme	3-hydroxyanthranilic	733:752	arg1	acid					754:757	3-hydroxyanthranilic acid	733:757	3-hydroxyanthranilic acid (3-HAA)	733:765	Previous studies showed that the ring A moiety is derived from chorismate, which is converted to 3-hydroxyanthranilic acid (3-HAA) by a 2-amino-2-deoxyisochorismate (ADIC) synthase, a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase, and a DHHA dehydrogenase.
33493986	6	9	theme	moiety	1266:1271	arg1	mechanism					1242:1250	the biosynthetic mechanism	1225:1250	the biosynthetic mechanism of the ring A moiety of PAUs	1225:1279	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	3	10	theme	combinatorial	543:555	arg1	biosynthesis					557:568	combinatorial biosynthesis	543:568	combinatorial biosynthesis	543:568	Elucidation of the biosynthetic mechanism of the ring A moiety may facilitate its structure modifications by combinatorial biosynthesis to generate PAU analogues with enhanced bioactivity or stability.
33493986	5	11	theme	conversion	942:951	arg1	process					953:959	the conversion process	938:959	the conversion process from 3-HAA to the highly decorated ring A moiety of PAUs	938:1016	Unfortunately, little is known about the conversion process from 3-HAA to the highly decorated ring A moiety of PAUs.
33493986	1	12	theme	antibacterial	179:191	arg1	activities					193:202	attractive antibacterial activities	168:202	attractive antibacterial activities against Gram-positive bacteria	168:233	Paulomycins (PAUs) refer to a group of glycosylated antibiotics with attractive antibacterial activities against Gram-positive bacteria.
33493986	6	13	theme	A	1264:1264	arg1	moiety					1266:1271	the ring A moiety	1255:1271	the ring A moiety of PAUs	1255:1279	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	4	14	theme	ADIC	802:805	arg1	synthase					808:815	a 2-amino-2-deoxyisochorismate (ADIC) synthase	770:815	a 2-amino-2-deoxyisochorismate (ADIC) synthase	770:815	Previous studies showed that the ring A moiety is derived from chorismate, which is converted to 3-hydroxyanthranilic acid (3-HAA) by a 2-amino-2-deoxyisochorismate (ADIC) synthase, a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase, and a DHHA dehydrogenase.
33493986	2	15	theme	antibacterial	386:398	arg1	activities					400:409	the antibacterial activities	382:409	the antibacterial activities of PAUs	382:417	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	6	16	theme	ring	1259:1262	arg1	moiety					1266:1271	the ring A moiety	1255:1271	the ring A moiety of PAUs	1255:1279	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	2	17	from	condition	353:361	arg1	form					338:341	a quinone-type form	323:341	a quinone-type form	323:341	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	6	18	theme	in vitro	1163:1170	arg1	studies					1172:1178	in vitro studies	1163:1178	in vitro studies	1163:1178	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	6	19	theme	unprecedented	1062:1074	arg1	Pau17					1050:1054	Pau17	1050:1054	Pau17	1050:1054	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	6	19	theme	unprecedented	1062:1074	arg1	6-hydroxylase					1082:1094	an unprecedented 3-HAA 6-hydroxylase	1059:1094	an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies	1059:1178	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	3	20	with	analogues	586:594	arg1	stability					625:633	stability	625:633	stability	625:633	Elucidation of the biosynthetic mechanism of the ring A moiety may facilitate its structure modifications by combinatorial biosynthesis to generate PAU analogues with enhanced bioactivity or stability.
33493986	3	20	with	analogues	586:594	arg1	bioactivity					610:620	bioactivity	610:620	bioactivity	610:620	Elucidation of the biosynthetic mechanism of the ring A moiety may facilitate its structure modifications by combinatorial biosynthesis to generate PAU analogues with enhanced bioactivity or stability.
33493986	6	21	theme	forward	1198:1204	arg1	step					1193:1196	one step forward	1189:1204	one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs	1189:1279	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	3	22	theme	enhanced	601:608	arg1	bioactivity					610:620	bioactivity	610:620	bioactivity	610:620	Elucidation of the biosynthetic mechanism of the ring A moiety may facilitate its structure modifications by combinatorial biosynthesis to generate PAU analogues with enhanced bioactivity or stability.
33493986	1	23	theme	Gram-positive	212:224	arg1	bacteria					226:233	Gram-positive bacteria	212:233	Gram-positive bacteria	212:233	Paulomycins (PAUs) refer to a group of glycosylated antibiotics with attractive antibacterial activities against Gram-positive bacteria.
33493986	0	24	theme	3-hydroxyanthranilic	22:41	arg1	acid					43:46	a 3-hydroxyanthranilic acid	20:46	a 3-hydroxyanthranilic acid	20:46	Characterization of a 3-hydroxyanthranilic acid 6-hydroxylase involved in paulomycin biosynthesis.
33493986	5	25	theme	PAUs	1013:1016	arg1	moiety					1003:1008	the highly decorated ring A moiety	975:1008	the highly decorated ring A moiety of PAUs	975:1016	Unfortunately, little is known about the conversion process from 3-HAA to the highly decorated ring A moiety of PAUs.
33493986	3	26	theme	PAU	582:584	arg1	analogues					586:594	PAU analogues	582:594	PAU analogues with enhanced bioactivity or stability	582:633	Elucidation of the biosynthetic mechanism of the ring A moiety may facilitate its structure modifications by combinatorial biosynthesis to generate PAU analogues with enhanced bioactivity or stability.
33493986	6	27	theme	3-HAA	1076:1080	arg1	Pau17					1050:1054	Pau17	1050:1054	Pau17	1050:1054	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	6	27	theme	3-HAA	1076:1080	arg1	6-hydroxylase					1082:1094	an unprecedented 3-HAA 6-hydroxylase	1059:1094	an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies	1059:1178	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	4	28	theme	ring	669:672	arg1	moiety					676:681	the ring A moiety	665:681	the ring A moiety	665:681	Previous studies showed that the ring A moiety is derived from chorismate, which is converted to 3-hydroxyanthranilic acid (3-HAA) by a 2-amino-2-deoxyisochorismate (ADIC) synthase, a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase, and a DHHA dehydrogenase.
33493986	5	29	theme	ring	996:999	arg1	moiety					1003:1008	the highly decorated ring A moiety	975:1008	the highly decorated ring A moiety of PAUs	975:1016	Unfortunately, little is known about the conversion process from 3-HAA to the highly decorated ring A moiety of PAUs.
33493986	6	30	theme	responsible	1096:1106	arg1	Pau17					1050:1054	Pau17	1050:1054	Pau17	1050:1054	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	6	30	theme	responsible	1096:1106	arg1	6-hydroxylase					1082:1094	an unprecedented 3-HAA 6-hydroxylase	1059:1094	an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies	1059:1178	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	3	31	theme	ring	483:486	arg1	moiety					490:495	the ring A moiety	479:495	the ring A moiety	479:495	Elucidation of the biosynthetic mechanism of the ring A moiety may facilitate its structure modifications by combinatorial biosynthesis to generate PAU analogues with enhanced bioactivity or stability.
33493986	6	32	theme	biosynthetic	1229:1240	arg1	mechanism					1242:1250	the biosynthetic mechanism	1225:1250	the biosynthetic mechanism of the ring A moiety of PAUs	1225:1279	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	3	33	theme	mechanism	466:474	arg1	Elucidation					434:444	Elucidation	434:444	Elucidation of the biosynthetic mechanism of the ring A moiety	434:495	Elucidation of the biosynthetic mechanism of the ring A moiety may facilitate its structure modifications by combinatorial biosynthesis to generate PAU analogues with enhanced bioactivity or stability.
33493986	2	34	theme	A	264:264	arg1	moiety					266:271	a special ring A moiety	249:271	a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly	249:431	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	2	34	theme	A	264:264	arg1	prone					281:285	prone	281:285	prone	281:285	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	5	35	from	3-HAA	966:970	arg1	process					953:959	the conversion process	938:959	the conversion process from 3-HAA to the highly decorated ring A moiety of PAUs	938:1016	Unfortunately, little is known about the conversion process from 3-HAA to the highly decorated ring A moiety of PAUs.
33493986	2	36	theme	PAUs	414:417	arg1	activities					400:409	the antibacterial activities	382:409	the antibacterial activities of PAUs	382:417	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	0	37	theme	acid	43:46	arg1	Characterization					0:15	Characterization	0:15	Characterization of a 3-hydroxyanthranilic acid	0:46	Characterization of a 3-hydroxyanthranilic acid 6-hydroxylase involved in paulomycin biosynthesis.
33493986	2	38	theme	ring	259:262	arg1	moiety					266:271	a special ring A moiety	249:271	a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly	249:431	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	2	38	theme	ring	259:262	arg1	prone					281:285	prone	281:285	prone	281:285	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	2	39	contain	contain	241:247	arg2	prone					281:285	prone	281:285	prone	281:285	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	2	39	contain	contain	241:247	arg1	They					236:239	They	236:239	They	236:239	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	2	39	contain	contain	241:247	arg2	moiety					266:271	a special ring A moiety	249:271	a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly	249:431	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	2	40	theme	special	251:257	arg1	moiety					266:271	a special ring A moiety	249:271	a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly	249:431	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	2	40	theme	special	251:257	arg1	prone					281:285	prone	281:285	prone	281:285	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	6	41	theme	3-HAA	1130:1134	arg1	conversion					1116:1125	the conversion	1112:1125	the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies	1112:1178	In this work, we characterized Pau17 as an unprecedented 3-HAA 6-hydroxylase responsible for the conversion of 3-HAA to 3,6-DHAA by in vivo and in vitro studies, pushing one step forward toward elucidating the biosynthetic mechanism of the ring A moiety of PAUs.
33493986	2	42	theme	acidic	346:351	arg1	condition					353:361	acidic condition	346:361	acidic condition	346:361	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	1	43	gly	glycosylated	138:149	arg1	antibiotics					151:161	glycosylated antibiotics	138:161	glycosylated antibiotics with attractive antibacterial activities against Gram-positive bacteria	138:233	Paulomycins (PAUs) refer to a group of glycosylated antibiotics with attractive antibacterial activities against Gram-positive bacteria.
33493986	4	44	theme	DHHA	859:862	arg1	synthase					865:872	a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase	818:872	a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase	818:872	Previous studies showed that the ring A moiety is derived from chorismate, which is converted to 3-hydroxyanthranilic acid (3-HAA) by a 2-amino-2-deoxyisochorismate (ADIC) synthase, a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase, and a DHHA dehydrogenase.
33493986	4	45	theme	acid	853:856	arg1	synthase					865:872	a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase	818:872	a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase	818:872	Previous studies showed that the ring A moiety is derived from chorismate, which is converted to 3-hydroxyanthranilic acid (3-HAA) by a 2-amino-2-deoxyisochorismate (ADIC) synthase, a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase, and a DHHA dehydrogenase.
33493986	3	46	theme	A	488:488	arg1	moiety					490:495	the ring A moiety	479:495	the ring A moiety	479:495	Elucidation of the biosynthetic mechanism of the ring A moiety may facilitate its structure modifications by combinatorial biosynthesis to generate PAU analogues with enhanced bioactivity or stability.
33493986	5	47	theme	A	1001:1001	arg1	moiety					1003:1008	the highly decorated ring A moiety	975:1008	the highly decorated ring A moiety of PAUs	975:1016	Unfortunately, little is known about the conversion process from 3-HAA to the highly decorated ring A moiety of PAUs.
33493986	2	48	theme	quinone-type	325:336	arg1	form					338:341	a quinone-type form	323:341	a quinone-type form	323:341	They contain a special ring A moiety that is prone to dehydrate between C-4 and C-5 to a quinone-type form at acidic condition, which will reduce the antibacterial activities of PAUs significantly.
33493986	4	49	theme	Previous	636:643	arg1	studies					645:651	Previous studies	636:651	Previous studies	636:651	Previous studies showed that the ring A moiety is derived from chorismate, which is converted to 3-hydroxyanthranilic acid (3-HAA) by a 2-amino-2-deoxyisochorismate (ADIC) synthase, a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase, and a DHHA dehydrogenase.
33493986	4	50	theme	A	674:674	arg1	moiety					676:681	the ring A moiety	665:681	the ring A moiety	665:681	Previous studies showed that the ring A moiety is derived from chorismate, which is converted to 3-hydroxyanthranilic acid (3-HAA) by a 2-amino-2-deoxyisochorismate (ADIC) synthase, a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase, and a DHHA dehydrogenase.
33493986	4	51	theme	2,3-dihydro-3-hydroxyanthranilic	820:851	arg1	synthase					865:872	a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase	818:872	a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase	818:872	Previous studies showed that the ring A moiety is derived from chorismate, which is converted to 3-hydroxyanthranilic acid (3-HAA) by a 2-amino-2-deoxyisochorismate (ADIC) synthase, a 2,3-dihydro-3-hydroxyanthranilic acid (DHHA) synthase, and a DHHA dehydrogenase.
33493986	1	52	theme	glycosylated	138:149	arg1	antibiotics					151:161	glycosylated antibiotics	138:161	glycosylated antibiotics with attractive antibacterial activities against Gram-positive bacteria	138:233	Paulomycins (PAUs) refer to a group of glycosylated antibiotics with attractive antibacterial activities against Gram-positive bacteria.
33493986	3	53	theme	biosynthetic	453:464	arg1	mechanism					466:474	the biosynthetic mechanism	449:474	the biosynthetic mechanism of the ring A moiety	449:495	Elucidation of the biosynthetic mechanism of the ring A moiety may facilitate its structure modifications by combinatorial biosynthesis to generate PAU analogues with enhanced bioactivity or stability.
33493986	0	54	theme	paulomycin	74:83	arg1	biosynthesis					85:96	paulomycin biosynthesis	74:96	paulomycin biosynthesis	74:96	Characterization of a 3-hydroxyanthranilic acid 6-hydroxylase involved in paulomycin biosynthesis.
33493986	5	55	theme	decorated	986:994	arg1	moiety					1003:1008	the highly decorated ring A moiety	975:1008	the highly decorated ring A moiety of PAUs	975:1016	Unfortunately, little is known about the conversion process from 3-HAA to the highly decorated ring A moiety of PAUs.
33493986	1	56	theme	antibiotics	151:161	arg1	group					129:133	a group	127:133	a group of glycosylated antibiotics with attractive antibacterial activities against Gram-positive bacteria	127:233	Paulomycins (PAUs) refer to a group of glycosylated antibiotics with attractive antibacterial activities against Gram-positive bacteria.
33493986	1	56	theme	antibiotics	151:161	arg1	antibiotics					151:161	glycosylated antibiotics	138:161	glycosylated antibiotics with attractive antibacterial activities against Gram-positive bacteria	138:233	Paulomycins (PAUs) refer to a group of glycosylated antibiotics with attractive antibacterial activities against Gram-positive bacteria.
34152332	0	0	theme	quantitative	99:110	arg1	detection					125:133	quantitative colorimetric detection	99:133	quantitative colorimetric detection of pesticides in a complex matrix	99:167	Porous chitosan/partially reduced graphene oxide/diatomite composite as an efficient adsorbent for quantitative colorimetric detection of pesticides in a complex matrix.
34152332	3	1	contain	had	490:492	arg2	effect					503:508	a strong effect	494:508	a strong effect	494:508	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	3	1	contain	had	490:492	arg1	matrix					483:488	a complex tea matrix	469:488	a complex tea matrix	469:488	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	2	2	from	interferents	420:431	arg1	matrix					446:451	a complex matrix	436:451	a complex matrix	436:451	However, it is still a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix.
34152332	2	3	theme	current	364:370	arg1	methods					389:395	the current visual detection methods	360:395	the current visual detection methods due to the presence of interferents in a complex matrix	360:451	However, it is still a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix.
34152332	6	4	theme	pesticides	913:922	arg1	detection					900:908	the quantitative detection	883:908	the quantitative detection of pesticides in a complex matrix	883:942	A colorimetric sensing platform for the quantitative detection of pesticides in a complex matrix was successfully established.
34152332	9	5	from	detection	1340:1348	arg1	tea					1377:1379	tea	1377:1379	tea	1377:1379	The limits of detection of phosalone and thiram in tea were 90 nM and 13.8 nM, respectively.
34152332	10	6	from	application	1488:1498	arg1	fields					1563:1568	fields	1563:1568	fields like environmental protection, food safety and bioanalysis	1563:1627	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	10	6	from	application	1488:1498	arg1	variety					1552:1558	a variety	1550:1558	a variety of fields like environmental protection, food safety and bioanalysis	1550:1627	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	2	7	from	matrix	446:451	arg1	presence					408:415	the presence	404:415	the presence of interferents in a complex matrix	404:451	However, it is still a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix.
34152332	2	8	from	detection	338:346	arg1	food					351:354	food	351:354	food	351:354	However, it is still a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix.
34152332	3	9	theme	gold	515:518	arg1	nanoparticles					520:532	gold nanoparticles	515:532	gold nanoparticles (Au NPs)	515:541	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	3	9	theme	gold	515:518	arg1	NPs					538:540	Au NPs	535:540	Au NPs	535:540	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	1	10	dep	On-site	170:176	arg1	free					190:193	free	190:193	free	190:193	On-site, instrument free quantitative analysis of pesticides is of significant importance for food safety control.
34152332	0	11	theme	colorimetric	112:123	arg1	detection					125:133	quantitative colorimetric detection	99:133	quantitative colorimetric detection of pesticides in a complex matrix	99:167	Porous chitosan/partially reduced graphene oxide/diatomite composite as an efficient adsorbent for quantitative colorimetric detection of pesticides in a complex matrix.
34152332	6	12	theme	quantitative	887:898	arg1	detection					900:908	the quantitative detection	883:908	the quantitative detection of pesticides in a complex matrix	883:942	A colorimetric sensing platform for the quantitative detection of pesticides in a complex matrix was successfully established.
34152332	9	13	from	limits	1330:1335	arg1	tea					1377:1379	tea	1377:1379	tea	1377:1379	The limits of detection of phosalone and thiram in tea were 90 nM and 13.8 nM, respectively.
34152332	8	14	theme	quantitative	1289:1300	arg1	analysis					1302:1309	quantitative analysis	1289:1309	quantitative analysis of pesticides	1289:1323	The G/R values and A700/525 values obtained from UV-vis spectra could be used for quantitative analysis of pesticides.
34152332	3	15	theme	complex	471:477	arg1	matrix					483:488	a complex tea matrix	469:488	a complex tea matrix	469:488	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	0	16	theme	pesticides	138:147	arg1	detection					125:133	quantitative colorimetric detection	99:133	quantitative colorimetric detection of pesticides in a complex matrix	99:167	Porous chitosan/partially reduced graphene oxide/diatomite composite as an efficient adsorbent for quantitative colorimetric detection of pesticides in a complex matrix.
34152332	8	17	theme	UV-vis	1256:1261	arg1	spectra					1263:1269	UV-vis spectra	1256:1269	UV-vis spectra	1256:1269	The G/R values and A700/525 values obtained from UV-vis spectra could be used for quantitative analysis of pesticides.
34152332	7	18	theme	smartphone	1079:1088	arg1	camera					1067:1072	the camera	1063:1072	the camera of a smartphone	1063:1088	The color changes of the aggregation of Au NPs induced by pesticides were captured using the camera of a smartphone and the images were processed with average RGB (red, green, and blue) values obtained using self-developed software.
34152332	8	19	theme	A700/525	1226:1233	arg1	values					1235:1240	A700/525 values	1226:1240	A700/525 values	1226:1240	The G/R values and A700/525 values obtained from UV-vis spectra could be used for quantitative analysis of pesticides.
34152332	3	20	dep	based	543:547	arg1	nanoparticles					520:532	gold nanoparticles	515:532	gold nanoparticles (Au NPs)	515:541	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	3	20	dep	based	543:547	arg1	NPs					538:540	Au NPs	535:540	Au NPs	535:540	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	10	21	theme	colorimetric	1511:1522	arg1	detection					1537:1545	on-site colorimetric quantitative detection	1503:1545	on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis	1503:1627	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	8	22	theme	pesticides	1314:1323	arg1	analysis					1302:1309	quantitative analysis	1289:1309	quantitative analysis of pesticides	1289:1323	The G/R values and A700/525 values obtained from UV-vis spectra could be used for quantitative analysis of pesticides.
34152332	1	23	theme	quantitative	195:206	arg1	analysis					208:215	On-site, instrument free quantitative analysis	170:215	On-site, instrument free quantitative analysis of pesticides	170:229	On-site, instrument free quantitative analysis of pesticides is of significant importance for food safety control.
34152332	10	24	theme	fields	1563:1568	arg1	fields					1563:1568	fields	1563:1568	fields like environmental protection, food safety and bioanalysis	1563:1627	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	10	24	theme	fields	1563:1568	arg1	variety					1552:1558	a variety	1550:1558	a variety of fields like environmental protection, food safety and bioanalysis	1550:1627	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	10	25	theme	wide	1483:1486	arg1	application					1488:1498	wide application	1483:1498	wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis	1483:1627	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	7	26	dep	RGB	1133:1135	arg1	green					1143:1147	green	1143:1147	green	1143:1147	The color changes of the aggregation of Au NPs induced by pesticides were captured using the camera of a smartphone and the images were processed with average RGB (red, green, and blue) values obtained using self-developed software.
34152332	7	26	dep	RGB	1133:1135	arg1	blue					1154:1157	blue	1154:1157	blue	1154:1157	The color changes of the aggregation of Au NPs induced by pesticides were captured using the camera of a smartphone and the images were processed with average RGB (red, green, and blue) values obtained using self-developed software.
34152332	7	26	dep	RGB	1133:1135	arg1	red					1138:1140	red	1138:1140	red	1138:1140	The color changes of the aggregation of Au NPs induced by pesticides were captured using the camera of a smartphone and the images were processed with average RGB (red, green, and blue) values obtained using self-developed software.
34152332	10	27	theme	on-site	1503:1509	arg1	detection					1537:1545	on-site colorimetric quantitative detection	1503:1545	on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis	1503:1627	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	2	28	theme	pesticide	328:336	arg1	detection					338:346	pesticide detection	328:346	pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix	328:451	However, it is still a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix.
34152332	3	29	theme	strong	496:501	arg1	effect					503:508	a strong effect	494:508	a strong effect	494:508	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	2	30	theme	due	397:399	arg1	methods					389:395	the current visual detection methods	360:395	the current visual detection methods due to the presence of interferents in a complex matrix	360:451	However, it is still a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix.
34152332	3	31	theme	Au	535:536	arg1	nanoparticles					520:532	gold nanoparticles	515:532	gold nanoparticles (Au NPs)	515:541	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	3	31	theme	Au	535:536	arg1	NPs					538:540	Au NPs	535:540	Au NPs	535:540	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	10	32	from	detection	1537:1545	arg1	fields					1563:1568	fields	1563:1568	fields like environmental protection, food safety and bioanalysis	1563:1627	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	10	32	from	detection	1537:1545	arg1	variety					1552:1558	a variety	1550:1558	a variety of fields like environmental protection, food safety and bioanalysis	1550:1627	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	4	33	theme	reduced	636:642	arg1	graphene					644:651	a porous chitosan/partially reduced graphene	608:651	a porous chitosan/partially reduced graphene oxide/diatomite (CS/prGO/DM) composite	608:690	Here, a porous chitosan/partially reduced graphene oxide/diatomite (CS/prGO/DM) composite was successfully synthesized via a facile hydrothermal treatment.
34152332	0	34	theme	graphene	34:41	arg1	composite					59:67	graphene oxide/diatomite composite	34:67	graphene oxide/diatomite composite	34:67	Porous chitosan/partially reduced graphene oxide/diatomite composite as an efficient adsorbent for quantitative colorimetric detection of pesticides in a complex matrix.
34152332	0	34	theme	graphene	34:41	arg1	adsorbent					85:93	adsorbent	85:93	adsorbent	85:93	Porous chitosan/partially reduced graphene oxide/diatomite composite as an efficient adsorbent for quantitative colorimetric detection of pesticides in a complex matrix.
34152332	10	35	theme	graphene-based	1439:1452	arg1	materials					1454:1462	graphene-based materials	1439:1462	graphene-based materials	1439:1462	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	4	36	theme	hydrothermal	734:745	arg1	treatment					747:755	a facile hydrothermal treatment	725:755	a facile hydrothermal treatment	725:755	Here, a porous chitosan/partially reduced graphene oxide/diatomite (CS/prGO/DM) composite was successfully synthesized via a facile hydrothermal treatment.
34152332	1	37	theme	pesticides	220:229	arg1	analysis					208:215	On-site, instrument free quantitative analysis	170:215	On-site, instrument free quantitative analysis of pesticides	170:229	On-site, instrument free quantitative analysis of pesticides is of significant importance for food safety control.
34152332	5	38	theme	different	810:818	arg1	types					820:824	different types	810:824	different types of tea interferents	810:844	It could act as an efficient adsorbent for removing different types of tea interferents.
34152332	6	39	theme	sensing	862:868	arg1	platform					870:877	A colorimetric sensing platform	847:877	A colorimetric sensing platform for the quantitative detection of pesticides in a complex matrix	847:942	A colorimetric sensing platform for the quantitative detection of pesticides in a complex matrix was successfully established.
34152332	2	40	theme	great	308:312	arg1	challenge					314:322	a great challenge	306:322	a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix	306:451	However, it is still a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix.
34152332	2	40	theme	great	308:312	arg1	it					294:295	it	294:295	it	294:295	However, it is still a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix.
34152332	2	41	theme	interferents	420:431	arg1	presence					408:415	the presence	404:415	the presence of interferents in a complex matrix	404:451	However, it is still a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix.
34152332	7	42	theme	RGB	1133:1135	arg1	values					1160:1165	average RGB (red, green, and blue) values	1125:1165	average RGB (red, green, and blue) values obtained using self-developed software	1125:1204	The color changes of the aggregation of Au NPs induced by pesticides were captured using the camera of a smartphone and the images were processed with average RGB (red, green, and blue) values obtained using self-developed software.
34152332	6	43	theme	colorimetric	849:860	arg1	platform					870:877	A colorimetric sensing platform	847:877	A colorimetric sensing platform for the quantitative detection of pesticides in a complex matrix	847:942	A colorimetric sensing platform for the quantitative detection of pesticides in a complex matrix was successfully established.
34152332	8	44	theme	G/R	1211:1213	arg1	values					1215:1220	G/R values	1211:1220	G/R values	1211:1220	The G/R values and A700/525 values obtained from UV-vis spectra could be used for quantitative analysis of pesticides.
34152332	5	45	theme	tea	829:831	arg1	interferents					833:844	tea interferents	829:844	tea interferents	829:844	It could act as an efficient adsorbent for removing different types of tea interferents.
34152332	0	46	theme	oxide/diatomite	43:57	arg1	composite					59:67	graphene oxide/diatomite composite	34:67	graphene oxide/diatomite composite	34:67	Porous chitosan/partially reduced graphene oxide/diatomite composite as an efficient adsorbent for quantitative colorimetric detection of pesticides in a complex matrix.
34152332	0	46	theme	oxide/diatomite	43:57	arg1	adsorbent					85:93	adsorbent	85:93	adsorbent	85:93	Porous chitosan/partially reduced graphene oxide/diatomite composite as an efficient adsorbent for quantitative colorimetric detection of pesticides in a complex matrix.
34152332	0	47	theme	complex	154:160	arg1	matrix					162:167	a complex matrix	152:167	a complex matrix	152:167	Porous chitosan/partially reduced graphene oxide/diatomite composite as an efficient adsorbent for quantitative colorimetric detection of pesticides in a complex matrix.
34152332	2	48	theme	complex	438:444	arg1	matrix					446:451	a complex matrix	436:451	a complex matrix	436:451	However, it is still a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix.
34152332	7	49	theme	Au	1014:1015	arg1	NPs					1017:1019	Au NPs	1014:1019	Au NPs induced by pesticides	1014:1041	The color changes of the aggregation of Au NPs induced by pesticides were captured using the camera of a smartphone and the images were processed with average RGB (red, green, and blue) values obtained using self-developed software.
34152332	1	50	theme	significant	237:247	arg1	importance					249:258	significant importance	237:258	significant importance	237:258	On-site, instrument free quantitative analysis of pesticides is of significant importance for food safety control.
34152332	10	51	theme	environmental	1575:1587	arg1	protection					1589:1598	environmental protection	1575:1598	environmental protection	1575:1598	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	10	52	theme	food	1601:1604	arg1	safety					1606:1611	food safety	1601:1611	food safety	1601:1611	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	8	53	dep	values	1215:1220	arg1	The					1207:1209	The	1207:1209	The	1207:1209	The G/R values and A700/525 values obtained from UV-vis spectra could be used for quantitative analysis of pesticides.
34152332	3	54	theme	based	543:547	arg1	sensor					562:567	a gold nanoparticles (Au NPs) based colorimetric sensor	513:567	a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides	513:599	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	7	55	theme	NPs	1017:1019	arg1	aggregation					999:1009	the aggregation	995:1009	the aggregation of Au NPs induced by pesticides	995:1041	The color changes of the aggregation of Au NPs induced by pesticides were captured using the camera of a smartphone and the images were processed with average RGB (red, green, and blue) values obtained using self-developed software.
34152332	3	56	theme	tea	479:481	arg1	matrix					483:488	a complex tea matrix	469:488	a complex tea matrix	469:488	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	7	57	theme	average	1125:1131	arg1	values					1160:1165	average RGB (red, green, and blue) values	1125:1165	average RGB (red, green, and blue) values obtained using self-developed software	1125:1204	The color changes of the aggregation of Au NPs induced by pesticides were captured using the camera of a smartphone and the images were processed with average RGB (red, green, and blue) values obtained using self-developed software.
34152332	6	58	theme	complex	929:935	arg1	matrix					937:942	a complex matrix	927:942	a complex matrix	927:942	A colorimetric sensing platform for the quantitative detection of pesticides in a complex matrix was successfully established.
34152332	9	59	from	tea	1377:1379	arg1	limits					1330:1335	The limits	1326:1335	The limits of detection of phosalone and thiram in tea	1326:1379	The limits of detection of phosalone and thiram in tea were 90 nM and 13.8 nM, respectively.
34152332	9	59	from	tea	1377:1379	arg1	nM					1389:1390	90 nM	1386:1390	90 nM	1386:1390	The limits of detection of phosalone and thiram in tea were 90 nM and 13.8 nM, respectively.
34152332	3	60	theme	colorimetric	549:560	arg1	sensor					562:567	a gold nanoparticles (Au NPs) based colorimetric sensor	513:567	a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides	513:599	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	7	61	theme	aggregation	999:1009	arg1	changes					984:990	The color changes	974:990	The color changes of the aggregation of Au NPs induced by pesticides	974:1041	The color changes of the aggregation of Au NPs induced by pesticides were captured using the camera of a smartphone and the images were processed with average RGB (red, green, and blue) values obtained using self-developed software.
34152332	4	62	theme	composite	682:690	arg1	graphene					644:651	a porous chitosan/partially reduced graphene	608:651	a porous chitosan/partially reduced graphene oxide/diatomite (CS/prGO/DM) composite	608:690	Here, a porous chitosan/partially reduced graphene oxide/diatomite (CS/prGO/DM) composite was successfully synthesized via a facile hydrothermal treatment.
34152332	9	63	theme	detection	1340:1348	arg1	limits					1330:1335	The limits	1326:1335	The limits of detection of phosalone and thiram in tea	1326:1379	The limits of detection of phosalone and thiram in tea were 90 nM and 13.8 nM, respectively.
34152332	9	63	theme	detection	1340:1348	arg1	nM					1389:1390	90 nM	1386:1390	90 nM	1386:1390	The limits of detection of phosalone and thiram in tea were 90 nM and 13.8 nM, respectively.
34152332	10	64	theme	detection	1537:1545	arg1	application					1488:1498	wide application	1483:1498	wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis	1483:1627	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	10	65	theme	quantitative	1524:1535	arg1	detection					1537:1545	on-site colorimetric quantitative detection	1503:1545	on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis	1503:1627	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	0	66	from	detection	125:133	arg1	matrix					162:167	a complex matrix	152:167	a complex matrix	152:167	Porous chitosan/partially reduced graphene oxide/diatomite composite as an efficient adsorbent for quantitative colorimetric detection of pesticides in a complex matrix.
34152332	3	67	theme	pesticides	590:599	arg1	detection					577:585	the detection	573:585	the detection of pesticides	573:599	In this study, a complex tea matrix had a strong effect on a gold nanoparticles (Au NPs) based colorimetric sensor for the detection of pesticides.
34152332	4	68	theme	facile	727:732	arg1	treatment					747:755	a facile hydrothermal treatment	725:755	a facile hydrothermal treatment	725:755	Here, a porous chitosan/partially reduced graphene oxide/diatomite (CS/prGO/DM) composite was successfully synthesized via a facile hydrothermal treatment.
34152332	1	69	theme	On-site	170:176	arg1	analysis					208:215	On-site, instrument free quantitative analysis	170:215	On-site, instrument free quantitative analysis of pesticides	170:229	On-site, instrument free quantitative analysis of pesticides is of significant importance for food safety control.
34152332	9	70	theme	phosalone	1353:1361	arg1	detection					1340:1348	detection	1340:1348	detection of phosalone and thiram in tea	1340:1379	The limits of detection of phosalone and thiram in tea were 90 nM and 13.8 nM, respectively.
34152332	7	71	theme	self-developed	1182:1195	arg1	software					1197:1204	self-developed software	1182:1204	self-developed software	1182:1204	The color changes of the aggregation of Au NPs induced by pesticides were captured using the camera of a smartphone and the images were processed with average RGB (red, green, and blue) values obtained using self-developed software.
34152332	5	72	theme	interferents	833:844	arg1	types					820:824	different types	810:824	different types of tea interferents	810:844	It could act as an efficient adsorbent for removing different types of tea interferents.
34152332	2	73	from	presence	408:415	arg1	matrix					446:451	a complex matrix	436:451	a complex matrix	436:451	However, it is still a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix.
34152332	2	74	theme	detection	379:387	arg1	methods					389:395	the current visual detection methods	360:395	the current visual detection methods due to the presence of interferents in a complex matrix	360:451	However, it is still a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix.
34152332	4	75	theme	porous	610:615	arg1	graphene					644:651	a porous chitosan/partially reduced graphene	608:651	a porous chitosan/partially reduced graphene oxide/diatomite (CS/prGO/DM) composite	608:690	Here, a porous chitosan/partially reduced graphene oxide/diatomite (CS/prGO/DM) composite was successfully synthesized via a facile hydrothermal treatment.
34152332	1	76	theme	food	264:267	arg1	control					276:282	food safety control	264:282	food safety control	264:282	On-site, instrument free quantitative analysis of pesticides is of significant importance for food safety control.
34152332	6	77	from	detection	900:908	arg1	matrix					937:942	a complex matrix	927:942	a complex matrix	927:942	A colorimetric sensing platform for the quantitative detection of pesticides in a complex matrix was successfully established.
34152332	10	78	from	variety	1552:1558	arg1	application					1488:1498	wide application	1483:1498	wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis	1483:1627	It is expected that graphene-based materials are attractive for wide application of on-site colorimetric quantitative detection in a variety of fields like environmental protection, food safety and bioanalysis.
34152332	8	79	used	used	1280:1283	arg2	values					1235:1240	A700/525 values	1226:1240	A700/525 values	1226:1240	The G/R values and A700/525 values obtained from UV-vis spectra could be used for quantitative analysis of pesticides.
34152332	8	79	used	used	1280:1283	arg2	values					1215:1220	G/R values	1211:1220	G/R values	1211:1220	The G/R values and A700/525 values obtained from UV-vis spectra could be used for quantitative analysis of pesticides.
34152332	7	80	theme	color	978:982	arg1	changes					984:990	The color changes	974:990	The color changes of the aggregation of Au NPs induced by pesticides	974:1041	The color changes of the aggregation of Au NPs induced by pesticides were captured using the camera of a smartphone and the images were processed with average RGB (red, green, and blue) values obtained using self-developed software.
34152332	2	81	theme	visual	372:377	arg1	methods					389:395	the current visual detection methods	360:395	the current visual detection methods due to the presence of interferents in a complex matrix	360:451	However, it is still a great challenge for pesticide detection in food via the current visual detection methods due to the presence of interferents in a complex matrix.
34152332	9	82	theme	thiram	1367:1372	arg1	detection					1340:1348	detection	1340:1348	detection of phosalone and thiram in tea	1340:1379	The limits of detection of phosalone and thiram in tea were 90 nM and 13.8 nM, respectively.
34152332	1	83	theme	safety	269:274	arg1	control					276:282	food safety control	264:282	food safety control	264:282	On-site, instrument free quantitative analysis of pesticides is of significant importance for food safety control.
32512394	0	0	theme	polysaccharides	101:115	arg1	identification					11:24	identification	11:24	identification	11:24	Synthesis, identification and bioavailability of Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides nanoparticles.
32512394	0	0	theme	polysaccharides	101:115	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis, identification and bioavailability of Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides nanoparticles.
32512394	0	0	theme	polysaccharides	101:115	arg1	bioavailability					30:44	bioavailability	30:44	bioavailability	30:44	Synthesis, identification and bioavailability of Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides nanoparticles.
32512394	5	1	theme	different	1210:1218	arg1	state					1220:1224	totally different state	1202:1224	totally different state	1202:1224	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	5	2	theme	release	1320:1326	arg1	characteristics					1328:1342	the sustained release characteristics	1306:1342	the sustained release characteristics in gastrointestinal system	1306:1369	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	1	3	theme	L.	249:250	arg1	nanoparticles					309:321	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles	225:321	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs)	225:335	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	1	3	theme	L.	249:250	arg1	NPs					332:334	JRP-HSP NPs	324:334	JRP-HSP NPs	324:334	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	0	4	theme	serotina	92:99	arg1	polysaccharides					101:115	Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides	49:115	Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides	49:115	Synthesis, identification and bioavailability of Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides nanoparticles.
32512394	5	5	theme	un-encapsulated	1172:1186	arg1	JRP					1188:1190	un-encapsulated JRP	1172:1190	un-encapsulated JRP	1172:1190	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	5	6	contain	possessed	1296:1304	arg1	NPs					1292:1294	JRP-HSP NPs	1284:1294	JRP-HSP NPs	1284:1294	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	5	6	contain	possessed	1296:1304	arg2	characteristics					1328:1342	the sustained release characteristics	1306:1342	the sustained release characteristics in gastrointestinal system	1306:1369	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	1	7	theme	L.	189:190	arg1	JRP					205:207	JRP	205:207	JRP	205:207	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	1	7	theme	L.	189:190	arg1	polyphenols					192:202	Juglans regia L. polyphenols	175:202	Juglans regia L. polyphenols (JRP)	175:208	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	1	8	theme	polyphenols-Hohenbuehelia	252:276	arg1	HSP					304:306	HSP	304:306	HSP	304:306	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	1	8	theme	polyphenols-Hohenbuehelia	252:276	arg1	polysaccharides					287:301	polyphenols-Hohenbuehelia serotina polysaccharides	252:301	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs)	225:335	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	3	9	theme	341.0 nm	712:719	arg1	potential					731:739	zeta potential	726:739	zeta potential	726:739	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	9	theme	341.0 nm	712:719	arg1	efficiency					665:674	encapsulation efficiency	651:674	encapsulation efficiency of 51.62%	651:684	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	9	theme	341.0 nm	712:719	arg1	size					704:707	average particle size	687:707	average particle size of 341.0 nm	687:719	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	5	10	theme	digestion	1008:1016	arg1	evaluation					967:976	evaluation	967:976	evaluation of simulated gastrointestinal digestion	967:1016	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	1	11	theme	serotina	278:285	arg1	HSP					304:306	HSP	304:306	HSP	304:306	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	1	11	theme	serotina	278:285	arg1	polysaccharides					287:301	polyphenols-Hohenbuehelia serotina polysaccharides	252:301	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs)	225:335	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	1	12	theme	electrostatic	363:375	arg1	interaction					377:387	electrostatic interaction	363:387	electrostatic interaction	363:387	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	3	13	theme	different	592:600	arg1	condition					602:610	different condition	592:610	different condition of mass ratio	592:624	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	1	14	theme	polysaccharides	287:301	arg1	nanoparticles					309:321	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles	225:321	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs)	225:335	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	1	14	theme	polysaccharides	287:301	arg1	NPs					332:334	JRP-HSP NPs	324:334	JRP-HSP NPs	324:334	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	3	15	with	NPs	635:637	arg1	potential					731:739	zeta potential	726:739	zeta potential	726:739	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	15	with	NPs	635:637	arg1	efficiency					665:674	encapsulation efficiency	651:674	encapsulation efficiency of 51.62%	651:684	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	15	with	NPs	635:637	arg1	size					704:707	average particle size	687:707	average particle size of 341.0 nm	687:719	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	4	16	theme	Morphological	869:881	arg1	analysis					883:890	Morphological analysis	869:890	Morphological analysis	869:890	Morphological analysis revealed JRP-HSP NPs (1:16) appeared spherical and almost uniform.
32512394	3	17	theme	NPs	576:578	arg1	kinds					559:563	four kinds	554:563	four kinds of JRP-HSP NPs prepared by different condition of mass ratio	554:624	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	1	18	theme	polyphenols	192:202	arg1	bioavailability					156:170	the bioavailability	152:170	the bioavailability of Juglans regia L. polyphenols (JRP) in human body	152:222	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	2	19	theme	NPs	503:505	arg1	morphologies					432:443	morphologies	432:443	morphologies	432:443	Moreover, the physicochemical properties, morphologies and gastrointestinal digestive characteristics of JRP-HSP NPs were respectively measured and analyzed.
32512394	2	19	theme	NPs	503:505	arg1	properties					420:429	the physicochemical properties	400:429	the physicochemical properties	400:429	Moreover, the physicochemical properties, morphologies and gastrointestinal digestive characteristics of JRP-HSP NPs were respectively measured and analyzed.
32512394	2	19	theme	NPs	503:505	arg1	characteristics					476:490	gastrointestinal digestive characteristics	449:490	gastrointestinal digestive characteristics	449:490	Moreover, the physicochemical properties, morphologies and gastrointestinal digestive characteristics of JRP-HSP NPs were respectively measured and analyzed.
32512394	3	20	theme	zeta	726:729	arg1	potential					731:739	zeta potential	726:739	zeta potential	726:739	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	21	theme	crystalline	845:855	arg1	properties					857:866	crystalline properties	845:866	crystalline properties	845:866	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	2	22	theme	physicochemical	404:418	arg1	properties					420:429	the physicochemical properties	400:429	the physicochemical properties	400:429	Moreover, the physicochemical properties, morphologies and gastrointestinal digestive characteristics of JRP-HSP NPs were respectively measured and analyzed.
32512394	2	23	theme	JRP-HSP	495:501	arg1	NPs					503:505	JRP-HSP NPs	495:505	JRP-HSP NPs	495:505	Moreover, the physicochemical properties, morphologies and gastrointestinal digestive characteristics of JRP-HSP NPs were respectively measured and analyzed.
32512394	5	24	theme	JRP	1161:1163	arg1	one					1143:1145	one	1143:1145	one	1143:1145	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	5	24	theme	JRP	1161:1163	arg1	JRP					1161:1163	undigested JRP	1150:1163	undigested JRP	1150:1163	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	1	25	from	bioavailability	156:170	arg1	body					219:222	human body	213:222	human body	213:222	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	3	26	theme	mass	615:618	arg1	ratio					620:624	mass ratio	615:624	mass ratio	615:624	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	27	theme	ratio	620:624	arg1	condition					602:610	different condition	592:610	different condition of mass ratio	592:624	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	28	theme	better	764:769	arg1	stability					815:823	thermal stability	807:823	thermal stability	807:823	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	28	theme	better	764:769	arg1	properties					787:796	better physicochemical properties	764:796	better physicochemical properties	764:796	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	28	theme	better	764:769	arg1	photostability					826:839	photostability	826:839	photostability	826:839	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	28	theme	better	764:769	arg1	properties					857:866	crystalline properties	845:866	crystalline properties	845:866	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	5	29	theme	gastrointestinal	1090:1105	arg1	digestion					1107:1115	gastrointestinal digestion	1090:1115	gastrointestinal digestion	1090:1115	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	2	30	theme	gastrointestinal	449:464	arg1	characteristics					476:490	gastrointestinal digestive characteristics	449:490	gastrointestinal digestive characteristics	449:490	Moreover, the physicochemical properties, morphologies and gastrointestinal digestive characteristics of JRP-HSP NPs were respectively measured and analyzed.
32512394	2	31	theme	digestive	466:474	arg1	characteristics					476:490	gastrointestinal digestive characteristics	449:490	gastrointestinal digestive characteristics	449:490	Moreover, the physicochemical properties, morphologies and gastrointestinal digestive characteristics of JRP-HSP NPs were respectively measured and analyzed.
32512394	3	32	theme	mv	750:751	arg1	NPs					635:637	JRP-HSP NPs	627:637	JRP-HSP NPs (1:16)	627:644	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	32	theme	mv	750:751	arg1	1:16					640:643	1:16	640:643	1:16	640:643	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	5	33	theme	JRP-HSP	1019:1025	arg1	NPs					1027:1029	JRP-HSP NPs	1019:1029	JRP-HSP NPs	1019:1029	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	5	34	from	characteristics	1328:1342	arg1	system					1364:1369	gastrointestinal system	1347:1369	gastrointestinal system	1347:1369	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	5	35	theme	gastrointestinal	991:1006	arg1	digestion					1008:1016	simulated gastrointestinal digestion	981:1016	simulated gastrointestinal digestion	981:1016	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	1	36	theme	human	213:217	arg1	body					219:222	human body	213:222	human body	213:222	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	3	37	theme	%	684:684	arg1	potential					731:739	zeta potential	726:739	zeta potential	726:739	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	37	theme	%	684:684	arg1	efficiency					665:674	encapsulation efficiency	651:674	encapsulation efficiency of 51.62%	651:684	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	37	theme	%	684:684	arg1	size					704:707	average particle size	687:707	average particle size of 341.0 nm	687:719	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	5	38	theme	phenolic	1058:1065	arg1	composition					1067:1077	phenolic composition	1058:1077	phenolic composition induced by gastrointestinal digestion	1058:1115	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	5	39	dep	prevented	1031:1039	arg1	similar					1128:1134	similar	1128:1134	similar	1128:1134	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	5	40	theme	composition	1067:1077	arg1	variation					1045:1053	the variation	1041:1053	the variation of phenolic composition induced by gastrointestinal digestion	1041:1115	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	0	41	theme	regia	57:61	arg1	polysaccharides					101:115	Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides	49:115	Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides	49:115	Synthesis, identification and bioavailability of Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides nanoparticles.
32512394	1	42	theme	JRP-HSP	324:330	arg1	nanoparticles					309:321	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles	225:321	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs)	225:335	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	1	42	theme	JRP-HSP	324:330	arg1	NPs					332:334	JRP-HSP NPs	324:334	JRP-HSP NPs	324:334	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	6	43	theme	non-toxic	1394:1402	arg1	strategy					1404:1411	a non-toxic strategy	1392:1411	a non-toxic strategy to encapsulate polyphenols for improving their bioavailability	1392:1474	This study provided a non-toxic strategy to encapsulate polyphenols for improving their bioavailability.
32512394	4	44	dep	spherical	929:937	arg1	uniform					950:956	uniform	950:956	uniform	950:956	Morphological analysis revealed JRP-HSP NPs (1:16) appeared spherical and almost uniform.
32512394	5	45	theme	undigested	1150:1159	arg1	JRP					1161:1163	undigested JRP	1150:1163	undigested JRP	1150:1163	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	0	46	theme	Juglans	49:55	arg1	polysaccharides					101:115	Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides	49:115	Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides	49:115	Synthesis, identification and bioavailability of Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides nanoparticles.
32512394	3	47	theme	physicochemical	771:785	arg1	stability					815:823	thermal stability	807:823	thermal stability	807:823	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	47	theme	physicochemical	771:785	arg1	properties					787:796	better physicochemical properties	764:796	better physicochemical properties	764:796	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	47	theme	physicochemical	771:785	arg1	photostability					826:839	photostability	826:839	photostability	826:839	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	47	theme	physicochemical	771:785	arg1	properties					857:866	crystalline properties	845:866	crystalline properties	845:866	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	48	theme	particle	695:702	arg1	size					704:707	average particle size	687:707	average particle size of 341.0 nm	687:719	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	49	theme	JRP-HSP	627:633	arg1	NPs					635:637	JRP-HSP NPs	627:637	JRP-HSP NPs (1:16)	627:644	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	49	theme	JRP-HSP	627:633	arg1	1:16					640:643	1:16	640:643	1:16	640:643	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	5	50	theme	gastrointestinal	1347:1362	arg1	system					1364:1369	gastrointestinal system	1347:1369	gastrointestinal system	1347:1369	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	5	51	theme	simulated	981:989	arg1	digestion					1008:1016	simulated gastrointestinal digestion	981:1016	simulated gastrointestinal digestion	981:1016	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	5	52	theme	JRP-HSP	1284:1290	arg1	NPs					1292:1294	JRP-HSP NPs	1284:1294	JRP-HSP NPs	1284:1294	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	3	53	theme	encapsulation	651:663	arg1	efficiency					665:674	encapsulation efficiency	651:674	encapsulation efficiency of 51.62%	651:684	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	1	54	theme	novel	229:233	arg1	nanoparticles					309:321	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles	225:321	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs)	225:335	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	1	54	theme	novel	229:233	arg1	NPs					332:334	JRP-HSP NPs	324:334	JRP-HSP NPs	324:334	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	0	55	theme	polyphenols-Hohenbuehelia	66:90	arg1	polysaccharides					101:115	Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides	49:115	Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides	49:115	Synthesis, identification and bioavailability of Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides nanoparticles.
32512394	3	56	theme	average	687:693	arg1	size					704:707	average particle size	687:707	average particle size of 341.0 nm	687:719	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	1	57	theme	Juglans	235:241	arg1	nanoparticles					309:321	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles	225:321	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs)	225:335	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	1	57	theme	Juglans	235:241	arg1	NPs					332:334	JRP-HSP NPs	324:334	JRP-HSP NPs	324:334	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	0	58	theme	L.	63:64	arg1	polysaccharides					101:115	Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides	49:115	Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides	49:115	Synthesis, identification and bioavailability of Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides nanoparticles.
32512394	3	59	theme	thermal	807:813	arg1	stability					815:823	thermal stability	807:823	thermal stability	807:823	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	3	60	theme	JRP-HSP	568:574	arg1	NPs					576:578	JRP-HSP NPs	568:578	JRP-HSP NPs	568:578	Among four kinds of JRP-HSP NPs prepared by different condition of mass ratio, JRP-HSP NPs (1:16) with encapsulation efficiency of 51.62%, average particle size of 341.0 nm, and zeta potential of -29.3 mv, presented better physicochemical properties, such as thermal stability, photostability and crystalline properties.
32512394	5	61	theme	sustained	1310:1318	arg1	characteristics					1328:1342	the sustained release characteristics	1306:1342	the sustained release characteristics in gastrointestinal system	1306:1369	Through evaluation of simulated gastrointestinal digestion, JRP-HSP NPs prevented the variation of phenolic composition induced by gastrointestinal digestion, which was similar as the one of undigested JRP, while un-encapsulated JRP exhibited totally different state due to degradation and biotransformation, suggesting that JRP-HSP NPs possessed the sustained release characteristics in gastrointestinal system.
32512394	1	62	theme	regia	243:247	arg1	nanoparticles					309:321	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles	225:321	the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs)	225:335	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
32512394	1	62	theme	regia	243:247	arg1	NPs					332:334	JRP-HSP NPs	324:334	JRP-HSP NPs	324:334	In order to improve the bioavailability of Juglans regia L. polyphenols (JRP) in human body, the novel Juglans regia L. polyphenols-Hohenbuehelia serotina polysaccharides (HSP) nanoparticles (JRP-HSP NPs) were synthesized based on electrostatic interaction.
34811557	7	0	theme	acid	1124:1127	arg1	production					1087:1096	the gradual production	1075:1096	the gradual production of acetic acid and lactic acid	1075:1127	Compared to GOS/inulin, we observed a delayed utilization of 3-FL, which was utilized at 60.3% after 36 h of fermentation, and induced the gradual production of acetic acid and lactic acid.
34811557	0	1	theme	gut	166:168	arg1	cells					181:185	gut epithelial cells	166:185	gut epithelial cells	166:185	Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells.
34811557	14	2	theme	differential	2190:2201	arg1	potencies					2203:2211	differential potencies	2190:2211	differential potencies	2190:2211	Our findings illustrate that fermentation of hMOs is very structure-dependent and different from the commonly applied GOS/inulin, which might lead to differential potencies to stimulate adhesion of commensal cells to gut epithelium and consequent microbial colonization.
34811557	3	3	theme	lacto-N-neotetraose	470:488	arg1	hydrolysis					456:465	acid hydrolysis	451:465	acid hydrolysis of lacto-N-neotetraose (LNnT)	451:495	Lacto-N-triaose II (LNT2) can be obtained by acid hydrolysis of lacto-N-neotetraose (LNnT).
34811557	15	4	theme	infant	2369:2374	arg1	formulas					2376:2383	tailored infant formulas	2360:2383	tailored infant formulas containing specific hMO molecules	2360:2417	This knowledge might contribute to the design of tailored infant formulas containing specific hMO molecules to meet the need of infants during the transition from breastfeeding to formula.
34811557	14	5	theme	microbial	2287:2295	arg1	colonization					2297:2308	consequent microbial colonization	2276:2308	consequent microbial colonization	2276:2308	Our findings illustrate that fermentation of hMOs is very structure-dependent and different from the commonly applied GOS/inulin, which might lead to differential potencies to stimulate adhesion of commensal cells to gut epithelium and consequent microbial colonization.
34811557	4	6	theme	health	541:546	arg1	benefits					548:555	health benefits	541:555	health benefits	541:555	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	1	7	theme	human	258:262	arg1	milk					264:267	human milk	258:267	human milk	258:267	Human milk oligosaccharides (hMOs) are unique bioactive components in human milk.
34811557	13	8	contain	had	2020:2022	arg2	effect					2032:2037	no such effect	2024:2037	no such effect	2024:2037	The fermentation digesta of LNT2 collected after 14 h, 24 h, and 36 h, and GOS/inulin after 24 h of fermentation significantly increased the adhesion of L. plantarum WCFS1 to Caco-2 cells, while 3-FL had no such effect.
34811557	13	8	contain	had	2020:2022	arg1	3-FL					2015:2018	3-FL	2015:2018	3-FL	2015:2018	The fermentation digesta of LNT2 collected after 14 h, 24 h, and 36 h, and GOS/inulin after 24 h of fermentation significantly increased the adhesion of L. plantarum WCFS1 to Caco-2 cells, while 3-FL had no such effect.
34811557	0	9	theme	Distinct	0:7	arg1	fermentation					9:20	Distinct fermentation	0:20	Distinct fermentation of human milk	0:34	Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells.
34811557	14	10	theme	gut	2257:2259	arg1	epithelium					2261:2270	gut epithelium	2257:2270	gut epithelium	2257:2270	Our findings illustrate that fermentation of hMOs is very structure-dependent and different from the commonly applied GOS/inulin, which might lead to differential potencies to stimulate adhesion of commensal cells to gut epithelium and consequent microbial colonization.
34811557	14	11	from	GOS/inulin	2158:2167	arg1	different					2122:2130	different	2122:2130	different	2122:2130	Our findings illustrate that fermentation of hMOs is very structure-dependent and different from the commonly applied GOS/inulin, which might lead to differential potencies to stimulate adhesion of commensal cells to gut epithelium and consequent microbial colonization.
34811557	4	12	theme	metabolic	622:630	arg1	acids					667:671	short-chain fatty acids	649:671	short-chain fatty acids (SCFAs)	649:679	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	4	12	theme	metabolic	622:630	arg1	products					632:639	microbial metabolic products	612:639	microbial metabolic products such as short-chain fatty acids (SCFAs)	612:679	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	5	13	theme	fecal	806:810	arg1	microbiota					812:821	pooled fecal microbiota	799:821	pooled fecal microbiota from 12-week-old infants	799:846	To gain more insight in fermentability, we performed in vitro fermentation studies of 3-FL and LNT2 using pooled fecal microbiota from 12-week-old infants.
34811557	1	14	theme	milk	194:197	arg1	components					244:253	unique bioactive components	227:253	unique bioactive components in human milk	227:267	Human milk oligosaccharides (hMOs) are unique bioactive components in human milk.
34811557	1	14	theme	milk	194:197	arg1	hMOs					217:220	hMOs	217:220	hMOs	217:220	Human milk oligosaccharides (hMOs) are unique bioactive components in human milk.
34811557	1	14	theme	milk	194:197	arg1	oligosaccharides					199:214	Human milk oligosaccharides	188:214	Human milk oligosaccharides (hMOs)	188:221	Human milk oligosaccharides (hMOs) are unique bioactive components in human milk.
34811557	12	15	theme	WCFS1	1797:1801	arg1	adhesion					1747:1754	adhesion	1747:1754	adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells	1747:1817	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	12	16	theme	present	1476:1482	arg1	GOS					1472:1474	The GOS	1468:1474	The GOS present in the GOS/inulin mixture	1468:1508	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	4	17	theme	microbiota	585:594	arg1	composition					596:606	infant microbiota composition	578:606	infant microbiota composition	578:606	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	1	18	from	components	244:253	arg1	milk					264:267	human milk	258:267	human milk	258:267	Human milk oligosaccharides (hMOs) are unique bioactive components in human milk.
34811557	7	19	theme	fermentation	1049:1060	arg1	h					1044:1044	36 h	1041:1044	36 h of fermentation	1041:1060	Compared to GOS/inulin, we observed a delayed utilization of 3-FL, which was utilized at 60.3% after 36 h of fermentation, and induced the gradual production of acetic acid and lactic acid.
34811557	12	20	theme	Caco-2	1806:1811	arg1	cells					1813:1817	Caco-2 cells	1806:1817	Caco-2 cells	1806:1817	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	0	21	theme	Lactobacillus	133:145	arg1	WCFS1					157:161	Lactobacillus plantarum WCFS1	133:161	Lactobacillus plantarum WCFS1	133:161	Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells.
34811557	0	22	from	microbiota	96:105	arg1	adhesion					121:128	adhesion	121:128	adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells	121:185	Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells.
34811557	6	23	theme	galacto-oligosaccharides	875:898	arg1	/inulin					905:911	The commonly investigated galacto-oligosaccharides (GOS)/inulin	849:911	The commonly investigated galacto-oligosaccharides (GOS)/inulin (9 : 1)	849:919	The commonly investigated galacto-oligosaccharides (GOS)/inulin (9 : 1) served as control.
34811557	6	24	dep	/inulin	905:911	arg1	9 					914:915	9 	914:915	9 : 1	914:918	The commonly investigated galacto-oligosaccharides (GOS)/inulin (9 : 1) served as control.
34811557	0	25	theme	WCFS1	157:161	arg1	adhesion					121:128	adhesion	121:128	adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells	121:185	Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells.
34811557	12	26	theme	low	1570:1572	arg1	DP					1574:1575	only low DP	1565:1575	only low DP	1565:1575	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	6	27	dep	9 	914:915	arg1	 1					917:918	 1	917:918	9 : 1	914:918	The commonly investigated galacto-oligosaccharides (GOS)/inulin (9 : 1) served as control.
34811557	7	28	theme	lactic	1117:1122	arg1	acid					1124:1127	lactic acid	1117:1127	lactic acid	1117:1127	Compared to GOS/inulin, we observed a delayed utilization of 3-FL, which was utilized at 60.3% after 36 h of fermentation, and induced the gradual production of acetic acid and lactic acid.
34811557	4	29	theme	short-chain	649:659	arg1	acids					667:671	short-chain fatty acids	649:671	short-chain fatty acids (SCFAs)	649:679	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	4	29	theme	short-chain	649:659	arg1	SCFAs					674:678	SCFAs	674:678	SCFAs	674:678	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	12	30	dep	h.	1607:1608	arg1	investigated					1734:1745	investigated	1734:1745	investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells	1734:1817	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	7	31	theme	acid	1108:1111	arg1	production					1087:1096	the gradual production	1075:1096	the gradual production of acetic acid and lactic acid	1075:1127	Compared to GOS/inulin, we observed a delayed utilization of 3-FL, which was utilized at 60.3% after 36 h of fermentation, and induced the gradual production of acetic acid and lactic acid.
34811557	10	32	theme	acetic	1311:1316	arg1	acid					1318:1321	acetic acid	1311:1321	acetic acid	1311:1321	After 14 h of fermentation, 90.1% was already utilized, and production of acetic acid, succinic acid, lactic acid and butyric acid was observed.
34811557	0	33	theme	infant	85:90	arg1	microbiota					96:105	infant gut microbiota	85:105	infant gut microbiota	85:105	Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells.
34811557	12	34	theme	commensal	1763:1771	arg1	WCFS1					1797:1801	the commensal Lactobacillus plantarum WCFS1	1759:1801	the commensal Lactobacillus plantarum WCFS1	1759:1801	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	10	35	theme	lactic	1339:1344	arg1	acid					1346:1349	lactic acid	1339:1349	lactic acid	1339:1349	After 14 h of fermentation, 90.1% was already utilized, and production of acetic acid, succinic acid, lactic acid and butyric acid was observed.
34811557	7	36	theme	gradual	1079:1085	arg1	production					1087:1096	the gradual production	1075:1096	the gradual production of acetic acid and lactic acid	1075:1127	Compared to GOS/inulin, we observed a delayed utilization of 3-FL, which was utilized at 60.3% after 36 h of fermentation, and induced the gradual production of acetic acid and lactic acid.
34811557	10	37	theme	acid	1333:1336	arg1	production					1297:1306	production	1297:1306	production of acetic acid, succinic acid, lactic acid and butyric acid	1297:1366	After 14 h of fermentation, 90.1% was already utilized, and production of acetic acid, succinic acid, lactic acid and butyric acid was observed.
34811557	5	38	theme	in	746:747	arg1	studies					768:774	in vitro fermentation studies	746:774	in vitro fermentation studies of 3-FL and LNT2	746:791	To gain more insight in fermentability, we performed in vitro fermentation studies of 3-FL and LNT2 using pooled fecal microbiota from 12-week-old infants.
34811557	12	39	theme	GOS/inulin	1491:1500	arg1	mixture					1502:1508	the GOS/inulin mixture	1487:1508	the GOS/inulin mixture	1487:1508	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	10	40	theme	acid	1363:1366	arg1	production					1297:1306	production	1297:1306	production of acetic acid, succinic acid, lactic acid and butyric acid	1297:1366	After 14 h of fermentation, 90.1% was already utilized, and production of acetic acid, succinic acid, lactic acid and butyric acid was observed.
34811557	5	41	theme	fermentation	755:766	arg1	studies					768:774	in vitro fermentation studies	746:774	in vitro fermentation studies of 3-FL and LNT2	746:791	To gain more insight in fermentability, we performed in vitro fermentation studies of 3-FL and LNT2 using pooled fecal microbiota from 12-week-old infants.
34811557	13	42	theme	such	2027:2030	arg1	effect					2032:2037	no such effect	2024:2037	no such effect	2024:2037	The fermentation digesta of LNT2 collected after 14 h, 24 h, and 36 h, and GOS/inulin after 24 h of fermentation significantly increased the adhesion of L. plantarum WCFS1 to Caco-2 cells, while 3-FL had no such effect.
34811557	12	43	from	present	1476:1482	arg1	mixture					1502:1508	the GOS/inulin mixture	1487:1508	the GOS/inulin mixture	1487:1508	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	0	44	theme	milk	31:34	arg1	fermentation					9:20	Distinct fermentation	0:20	Distinct fermentation of human milk	0:34	Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells.
34811557	12	45	theme	epithelial	1713:1722	arg1	cells					1724:1728	gut epithelial cells	1709:1728	gut epithelial cells	1709:1728	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	14	46	theme	cells	2248:2252	arg1	colonization					2297:2308	consequent microbial colonization	2276:2308	consequent microbial colonization	2276:2308	Our findings illustrate that fermentation of hMOs is very structure-dependent and different from the commonly applied GOS/inulin, which might lead to differential potencies to stimulate adhesion of commensal cells to gut epithelium and consequent microbial colonization.
34811557	14	46	theme	cells	2248:2252	arg1	adhesion					2226:2233	adhesion	2226:2233	adhesion of commensal cells to gut epithelium	2226:2270	Our findings illustrate that fermentation of hMOs is very structure-dependent and different from the commonly applied GOS/inulin, which might lead to differential potencies to stimulate adhesion of commensal cells to gut epithelium and consequent microbial colonization.
34811557	3	47	theme	acid	451:454	arg1	hydrolysis					456:465	acid hydrolysis	451:465	acid hydrolysis of lacto-N-neotetraose (LNnT)	451:495	Lacto-N-triaose II (LNT2) can be obtained by acid hydrolysis of lacto-N-neotetraose (LNnT).
34811557	12	48	theme	enhanced	1662:1669	arg1	colonization					1671:1682	enhanced colonization	1662:1682	enhanced colonization of commensal bacteria to gut epithelial cells	1662:1728	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	2	49	theme	present	311:317	arg1	hMO					319:321	an abundantly present hMO	297:321	an abundantly present hMO that can be produced in sufficient amounts to allow application in infant formula	297:403	3-Fucosyllactose (3-FL) is an abundantly present hMO that can be produced in sufficient amounts to allow application in infant formula.
34811557	2	49	theme	present	311:317	arg1	3-Fucosyllactose					270:285	3-Fucosyllactose	270:285	3-Fucosyllactose (3-FL)	270:292	3-Fucosyllactose (3-FL) is an abundantly present hMO that can be produced in sufficient amounts to allow application in infant formula.
34811557	13	50	theme	plantarum	1976:1984	arg1	WCFS1					1986:1990	L. plantarum WCFS1	1973:1990	L. plantarum WCFS1	1973:1990	The fermentation digesta of LNT2 collected after 14 h, 24 h, and 36 h, and GOS/inulin after 24 h of fermentation significantly increased the adhesion of L. plantarum WCFS1 to Caco-2 cells, while 3-FL had no such effect.
34811557	12	51	theme	commensal	1687:1695	arg1	bacteria					1697:1704	commensal bacteria	1687:1704	commensal bacteria	1687:1704	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	10	52	theme	fermentation	1251:1262	arg1	h					1246:1246	14 h	1243:1246	14 h of fermentation	1243:1262	After 14 h of fermentation, 90.1% was already utilized, and production of acetic acid, succinic acid, lactic acid and butyric acid was observed.
34811557	7	53	used	utilized	1017:1024	arg2	utilization					986:996	a delayed utilization	976:996	a delayed utilization	976:996	Compared to GOS/inulin, we observed a delayed utilization of 3-FL, which was utilized at 60.3% after 36 h of fermentation, and induced the gradual production of acetic acid and lactic acid.
34811557	6	54	theme	investigated	862:873	arg1	GOS					901:903	GOS	901:903	GOS	901:903	The commonly investigated galacto-oligosaccharides (GOS)/inulin (9 : 1) served as control.
34811557	6	54	theme	investigated	862:873	arg1	galacto-oligosaccharides					875:898	commonly investigated galacto-oligosaccharides	853:898	The commonly investigated galacto-oligosaccharides (GOS)/inulin (9 : 1)	849:919	The commonly investigated galacto-oligosaccharides (GOS)/inulin (9 : 1) served as control.
34811557	0	55	from	impact	111:116	arg1	adhesion					121:128	adhesion	121:128	adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells	121:185	Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells.
34811557	7	56	theme	acetic	1101:1106	arg1	acid					1108:1111	acetic acid	1101:1111	acetic acid	1101:1111	Compared to GOS/inulin, we observed a delayed utilization of 3-FL, which was utilized at 60.3% after 36 h of fermentation, and induced the gradual production of acetic acid and lactic acid.
34811557	0	57	theme	epithelial	170:179	arg1	cells					181:185	gut epithelial cells	166:185	gut epithelial cells	166:185	Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells.
34811557	15	58	theme	specific	2396:2403	arg1	molecules					2409:2417	specific hMO molecules	2396:2417	specific hMO molecules	2396:2417	This knowledge might contribute to the design of tailored infant formulas containing specific hMO molecules to meet the need of infants during the transition from breastfeeding to formula.
34811557	1	59	theme	bioactive	234:242	arg1	components					244:253	unique bioactive components	227:253	unique bioactive components in human milk	227:267	Human milk oligosaccharides (hMOs) are unique bioactive components in human milk.
34811557	1	59	theme	bioactive	234:242	arg1	oligosaccharides					199:214	Human milk oligosaccharides	188:214	Human milk oligosaccharides (hMOs)	188:221	Human milk oligosaccharides (hMOs) are unique bioactive components in human milk.
34811557	13	60	theme	L.	1973:1974	arg1	WCFS1					1986:1990	L. plantarum WCFS1	1973:1990	L. plantarum WCFS1	1973:1990	The fermentation digesta of LNT2 collected after 14 h, 24 h, and 36 h, and GOS/inulin after 24 h of fermentation significantly increased the adhesion of L. plantarum WCFS1 to Caco-2 cells, while 3-FL had no such effect.
34811557	15	61	theme	formulas	2376:2383	arg1	design					2350:2355	the design	2346:2355	the design of tailored infant formulas containing specific hMO molecules to meet the need of infants during the transition from breastfeeding to formula	2346:2497	This knowledge might contribute to the design of tailored infant formulas containing specific hMO molecules to meet the need of infants during the transition from breastfeeding to formula.
34811557	14	62	theme	consequent	2276:2285	arg1	colonization					2297:2308	consequent microbial colonization	2276:2308	consequent microbial colonization	2276:2308	Our findings illustrate that fermentation of hMOs is very structure-dependent and different from the commonly applied GOS/inulin, which might lead to differential potencies to stimulate adhesion of commensal cells to gut epithelium and consequent microbial colonization.
34811557	5	63	dep	in	746:747	arg1	vitro					749:753	vitro	749:753	vitro	749:753	To gain more insight in fermentability, we performed in vitro fermentation studies of 3-FL and LNT2 using pooled fecal microbiota from 12-week-old infants.
34811557	10	64	used	utilized	1283:1290	arg2	%					1269:1269	90.1%	1265:1269	90.1%	1265:1269	After 14 h of fermentation, 90.1% was already utilized, and production of acetic acid, succinic acid, lactic acid and butyric acid was observed.
34811557	13	65	theme	fermentation	1824:1835	arg1	digesta					1837:1843	The fermentation digesta	1820:1843	The fermentation digesta of LNT2 collected after 14 h, 24 h, and 36 h, and GOS/inulin after 24 h of fermentation	1820:1931	The fermentation digesta of LNT2 collected after 14 h, 24 h, and 36 h, and GOS/inulin after 24 h of fermentation significantly increased the adhesion of L. plantarum WCFS1 to Caco-2 cells, while 3-FL had no such effect.
34811557	5	66	theme	LNT2	788:791	arg1	studies					768:774	in vitro fermentation studies	746:774	in vitro fermentation studies of 3-FL and LNT2	746:791	To gain more insight in fermentability, we performed in vitro fermentation studies of 3-FL and LNT2 using pooled fecal microbiota from 12-week-old infants.
34811557	7	67	theme	3-FL	1001:1004	arg1	utilization					986:996	a delayed utilization	976:996	a delayed utilization	976:996	Compared to GOS/inulin, we observed a delayed utilization of 3-FL, which was utilized at 60.3% after 36 h of fermentation, and induced the gradual production of acetic acid and lactic acid.
34811557	5	68	theme	pooled	799:804	arg1	microbiota					812:821	pooled fecal microbiota	799:821	pooled fecal microbiota from 12-week-old infants	799:846	To gain more insight in fermentability, we performed in vitro fermentation studies of 3-FL and LNT2 using pooled fecal microbiota from 12-week-old infants.
34811557	12	69	from	mixture	1502:1508	arg1	present					1476:1482	present	1476:1482	present	1476:1482	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	4	70	theme	microbial	612:620	arg1	acids					667:671	short-chain fatty acids	649:671	short-chain fatty acids (SCFAs)	649:679	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	4	70	theme	microbial	612:620	arg1	products					632:639	microbial metabolic products	612:639	microbial metabolic products such as short-chain fatty acids (SCFAs)	612:679	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	11	71	theme	Collinsella	1427:1437	arg1	Bifidobacterium					1451:1465	Bifidobacterium	1451:1465	Bifidobacterium	1451:1465	LNT2 specifically increased the abundance of Collinsella, as well as Bifidobacterium.
34811557	11	71	theme	Collinsella	1427:1437	arg1	abundance					1414:1422	the abundance	1410:1422	the abundance of Collinsella	1410:1437	LNT2 specifically increased the abundance of Collinsella, as well as Bifidobacterium.
34811557	12	72	used	utilized	1589:1596	arg2	DP					1574:1575	only low DP	1565:1575	only low DP	1565:1575	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	1	73	theme	Human	188:192	arg1	components					244:253	unique bioactive components	227:253	unique bioactive components in human milk	227:267	Human milk oligosaccharides (hMOs) are unique bioactive components in human milk.
34811557	1	73	theme	Human	188:192	arg1	hMOs					217:220	hMOs	217:220	hMOs	217:220	Human milk oligosaccharides (hMOs) are unique bioactive components in human milk.
34811557	1	73	theme	Human	188:192	arg1	oligosaccharides					199:214	Human milk oligosaccharides	188:214	Human milk oligosaccharides (hMOs)	188:221	Human milk oligosaccharides (hMOs) are unique bioactive components in human milk.
34811557	14	74	theme	commensal	2238:2246	arg1	cells					2248:2252	commensal cells	2238:2252	commensal cells	2238:2252	Our findings illustrate that fermentation of hMOs is very structure-dependent and different from the commonly applied GOS/inulin, which might lead to differential potencies to stimulate adhesion of commensal cells to gut epithelium and consequent microbial colonization.
34811557	15	75	from	breastfeeding	2474:2486	arg1	transition					2458:2467	the transition	2454:2467	the transition from breastfeeding to formula	2454:2497	This knowledge might contribute to the design of tailored infant formulas containing specific hMO molecules to meet the need of infants during the transition from breastfeeding to formula.
34811557	15	76	theme	infants	2439:2445	arg1	need					2431:2434	the need	2427:2434	the need of infants	2427:2445	This knowledge might contribute to the design of tailored infant formulas containing specific hMO molecules to meet the need of infants during the transition from breastfeeding to formula.
34811557	13	77	theme	fermentation	1920:1931	arg1	h					1915:1915	24 h	1912:1915	24 h of fermentation	1912:1931	The fermentation digesta of LNT2 collected after 14 h, 24 h, and 36 h, and GOS/inulin after 24 h of fermentation significantly increased the adhesion of L. plantarum WCFS1 to Caco-2 cells, while 3-FL had no such effect.
34811557	4	78	contain	have	536:539	arg1	LNT2					512:515	LNT2	512:515	LNT2	512:515	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	4	78	contain	have	536:539	arg1	3-FL					503:506	3-FL	503:506	3-FL	503:506	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	4	78	contain	have	536:539	arg2	benefits					548:555	health benefits	541:555	health benefits	541:555	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	4	79	from	impact	568:573	arg1	acids					667:671	short-chain fatty acids	649:671	short-chain fatty acids (SCFAs)	649:679	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	4	79	from	impact	568:573	arg1	products					632:639	microbial metabolic products	612:639	microbial metabolic products such as short-chain fatty acids (SCFAs)	612:679	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	4	79	from	impact	568:573	arg1	composition					596:606	infant microbiota composition	578:606	infant microbiota composition	578:606	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	5	80	theme	3-FL	779:782	arg1	studies					768:774	in vitro fermentation studies	746:774	in vitro fermentation studies of 3-FL and LNT2	746:791	To gain more insight in fermentability, we performed in vitro fermentation studies of 3-FL and LNT2 using pooled fecal microbiota from 12-week-old infants.
34811557	12	81	theme	plantarum	1787:1795	arg1	WCFS1					1797:1801	the commensal Lactobacillus plantarum WCFS1	1759:1801	the commensal Lactobacillus plantarum WCFS1	1759:1801	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	4	82	theme	infant	578:583	arg1	composition					596:606	infant microbiota composition	578:606	infant microbiota composition	578:606	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	0	83	theme	plantarum	147:155	arg1	WCFS1					157:161	Lactobacillus plantarum WCFS1	133:161	Lactobacillus plantarum WCFS1	133:161	Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells.
34811557	4	84	theme	fatty	661:665	arg1	acids					667:671	short-chain fatty acids	649:671	short-chain fatty acids (SCFAs)	649:679	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	4	84	theme	fatty	661:665	arg1	SCFAs					674:678	SCFAs	674:678	SCFAs	674:678	Both 3-FL and LNT2 have been shown to have health benefits, but their impact on infant microbiota composition and microbial metabolic products such as short-chain fatty acids (SCFAs) is unknown.
34811557	14	85	theme	applied	2150:2156	arg1	GOS/inulin					2158:2167	the commonly applied GOS/inulin	2137:2167	the commonly applied GOS/inulin	2137:2167	Our findings illustrate that fermentation of hMOs is very structure-dependent and different from the commonly applied GOS/inulin, which might lead to differential potencies to stimulate adhesion of commensal cells to gut epithelium and consequent microbial colonization.
34811557	5	86	from	insight	706:712	arg1	fermentability					717:730	fermentability	717:730	fermentability	717:730	To gain more insight in fermentability, we performed in vitro fermentation studies of 3-FL and LNT2 using pooled fecal microbiota from 12-week-old infants.
34811557	15	87	theme	tailored	2360:2367	arg1	formulas					2376:2383	tailored infant formulas	2360:2383	tailored infant formulas containing specific hMO molecules	2360:2417	This knowledge might contribute to the design of tailored infant formulas containing specific hMO molecules to meet the need of infants during the transition from breastfeeding to formula.
34811557	8	88	theme	genus	1198:1202	arg1	bacteria					1157:1164	bacteria	1157:1164	bacteria of Bacteroides and Enterococcus genus	1157:1202	3-FL specifically enriched bacteria of Bacteroides and Enterococcus genus.
34811557	5	89	theme	more	701:704	arg1	insight					706:712	more insight	701:712	more insight in fermentability	701:730	To gain more insight in fermentability, we performed in vitro fermentation studies of 3-FL and LNT2 using pooled fecal microbiota from 12-week-old infants.
34811557	5	90	theme	12-week-old	828:838	arg1	infants					840:846	12-week-old infants	828:846	12-week-old infants	828:846	To gain more insight in fermentability, we performed in vitro fermentation studies of 3-FL and LNT2 using pooled fecal microbiota from 12-week-old infants.
34811557	10	91	theme	acid	1318:1321	arg1	production					1297:1306	production	1297:1306	production of acetic acid, succinic acid, lactic acid and butyric acid	1297:1366	After 14 h of fermentation, 90.1% was already utilized, and production of acetic acid, succinic acid, lactic acid and butyric acid was observed.
34811557	0	92	theme	gut	92:94	arg1	microbiota					96:105	infant gut microbiota	85:105	infant gut microbiota	85:105	Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells.
34811557	12	93	theme	Lactobacillus	1773:1785	arg1	WCFS1					1797:1801	the commensal Lactobacillus plantarum WCFS1	1759:1801	the commensal Lactobacillus plantarum WCFS1	1759:1801	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	5	94	from	infants	840:846	arg1	microbiota					812:821	pooled fecal microbiota	799:821	pooled fecal microbiota from 12-week-old infants	799:846	To gain more insight in fermentability, we performed in vitro fermentation studies of 3-FL and LNT2 using pooled fecal microbiota from 12-week-old infants.
34811557	15	95	contain	containing	2385:2394	arg2	molecules					2409:2417	specific hMO molecules	2396:2417	specific hMO molecules	2396:2417	This knowledge might contribute to the design of tailored infant formulas containing specific hMO molecules to meet the need of infants during the transition from breastfeeding to formula.
34811557	15	95	contain	containing	2385:2394	arg1	formulas					2376:2383	tailored infant formulas	2360:2383	tailored infant formulas containing specific hMO molecules	2360:2417	This knowledge might contribute to the design of tailored infant formulas containing specific hMO molecules to meet the need of infants during the transition from breastfeeding to formula.
34811557	14	96	theme	hMOs	2085:2088	arg1	fermentation					2069:2080	fermentation	2069:2080	fermentation of hMOs	2069:2088	Our findings illustrate that fermentation of hMOs is very structure-dependent and different from the commonly applied GOS/inulin, which might lead to differential potencies to stimulate adhesion of commensal cells to gut epithelium and consequent microbial colonization.
34811557	10	97	theme	succinic	1324:1331	arg1	acid					1333:1336	succinic acid	1324:1336	succinic acid	1324:1336	After 14 h of fermentation, 90.1% was already utilized, and production of acetic acid, succinic acid, lactic acid and butyric acid was observed.
34811557	2	98	theme	sufficient	347:356	arg1	amounts					358:364	sufficient amounts	347:364	sufficient amounts	347:364	3-Fucosyllactose (3-FL) is an abundantly present hMO that can be produced in sufficient amounts to allow application in infant formula.
34811557	0	99	theme	human	25:29	arg1	milk					31:34	human milk	25:34	human milk	25:34	Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells.
34811557	12	100	theme	gut	1709:1711	arg1	cells					1724:1728	gut epithelial cells	1709:1728	gut epithelial cells	1709:1728	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	10	101	theme	butyric	1355:1361	arg1	acid					1363:1366	butyric acid	1355:1366	butyric acid	1355:1366	After 14 h of fermentation, 90.1% was already utilized, and production of acetic acid, succinic acid, lactic acid and butyric acid was observed.
34811557	2	102	theme	infant	390:395	arg1	formula					397:403	infant formula	390:403	infant formula	390:403	3-Fucosyllactose (3-FL) is an abundantly present hMO that can be produced in sufficient amounts to allow application in infant formula.
34811557	8	103	theme	Bacteroides	1169:1179	arg1	bacteria					1157:1164	bacteria	1157:1164	bacteria of Bacteroides and Enterococcus genus	1157:1202	3-FL specifically enriched bacteria of Bacteroides and Enterococcus genus.
34811557	10	104	theme	acid	1346:1349	arg1	production					1297:1306	production	1297:1306	production of acetic acid, succinic acid, lactic acid and butyric acid	1297:1366	After 14 h of fermentation, 90.1% was already utilized, and production of acetic acid, succinic acid, lactic acid and butyric acid was observed.
34811557	7	105	theme	delayed	978:984	arg1	utilization					986:996	a delayed utilization	976:996	a delayed utilization	976:996	Compared to GOS/inulin, we observed a delayed utilization of 3-FL, which was utilized at 60.3% after 36 h of fermentation, and induced the gradual production of acetic acid and lactic acid.
34811557	12	106	attach	present	1476:1482	arg1	mixture					1502:1508	the GOS/inulin mixture	1487:1508	the GOS/inulin mixture	1487:1508	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	12	106	attach	present	1476:1482	arg2	GOS					1472:1474	The GOS	1468:1474	The GOS present in the GOS/inulin mixture	1468:1508	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	12	107	theme	bacteria	1697:1704	arg1	colonization					1671:1682	enhanced colonization	1662:1682	enhanced colonization of commensal bacteria to gut epithelial cells	1662:1728	The GOS present in the GOS/inulin mixture was completely fermented after 14 h, while for inulin, only low DP was rapidly utilized after 14 h. To determine whether the fermentation might lead to enhanced colonization of commensal bacteria to gut epithelial cells, we investigated adhesion of the commensal Lactobacillus plantarum WCFS1 to Caco-2 cells.
34811557	15	108	theme	hMO	2405:2407	arg1	molecules					2409:2417	specific hMO molecules	2396:2417	specific hMO molecules	2396:2417	This knowledge might contribute to the design of tailored infant formulas containing specific hMO molecules to meet the need of infants during the transition from breastfeeding to formula.
34811557	13	109	theme	WCFS1	1986:1990	arg1	adhesion					1961:1968	the adhesion	1957:1968	the adhesion of L. plantarum WCFS1 to Caco-2 cells	1957:2006	The fermentation digesta of LNT2 collected after 14 h, 24 h, and 36 h, and GOS/inulin after 24 h of fermentation significantly increased the adhesion of L. plantarum WCFS1 to Caco-2 cells, while 3-FL had no such effect.
34811557	2	110	from	application	375:385	arg1	formula					397:403	infant formula	390:403	infant formula	390:403	3-Fucosyllactose (3-FL) is an abundantly present hMO that can be produced in sufficient amounts to allow application in infant formula.
34811557	13	111	theme	Caco-2	1995:2000	arg1	cells					2002:2006	Caco-2 cells	1995:2006	Caco-2 cells	1995:2006	The fermentation digesta of LNT2 collected after 14 h, 24 h, and 36 h, and GOS/inulin after 24 h of fermentation significantly increased the adhesion of L. plantarum WCFS1 to Caco-2 cells, while 3-FL had no such effect.
34811557	13	112	theme	LNT2	1848:1851	arg1	digesta					1837:1843	The fermentation digesta	1820:1843	The fermentation digesta of LNT2 collected after 14 h, 24 h, and 36 h, and GOS/inulin after 24 h of fermentation	1820:1931	The fermentation digesta of LNT2 collected after 14 h, 24 h, and 36 h, and GOS/inulin after 24 h of fermentation significantly increased the adhesion of L. plantarum WCFS1 to Caco-2 cells, while 3-FL had no such effect.
34811557	1	113	theme	unique	227:232	arg1	components					244:253	unique bioactive components	227:253	unique bioactive components in human milk	227:267	Human milk oligosaccharides (hMOs) are unique bioactive components in human milk.
34811557	1	113	theme	unique	227:232	arg1	oligosaccharides					199:214	Human milk oligosaccharides	188:214	Human milk oligosaccharides (hMOs)	188:221	Human milk oligosaccharides (hMOs) are unique bioactive components in human milk.
31943376	4	0	theme	Rotatable	535:543	arg1	Design					545:550	Central Composite Rotatable Design	517:550	Central Composite Rotatable Design statistical analysis	517:571	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	4	1	theme	Central	517:523	arg1	Design					545:550	Central Composite Rotatable Design	517:550	Central Composite Rotatable Design statistical analysis	517:571	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	8	2	theme	nanocellulose	1275:1287	arg1	dimensions					1289:1298	nanocellulose dimensions	1275:1298	nanocellulose dimensions	1275:1298	The hydrolyzed material with the best statistical data, revealing a fiber diameter of 180 nm, disclosing to be biomaterial with nanocellulose dimensions.
31943376	4	3	from	increase	618:625	arg1	time					681:684	the 24-H hydrolysis time	661:684	the 24-H hydrolysis time	661:684	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	4	3	from	increase	618:625	arg1	%					656:656	10%	654:656	10% at the 24-H hydrolysis time	654:684	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	0	4	theme	Kraft	79:83	arg1	pulp					85:88	Kraft pulp	79:88	Kraft pulp	79:88	Statistical analysis of the crystallinity index of nanocellulose produced from Kraft pulp via controlled enzymatic hydrolysis.
31943376	8	5	with	material	1162:1169	arg1	data					1197:1200	the best statistical data	1176:1200	the best statistical data	1176:1200	The hydrolyzed material with the best statistical data, revealing a fiber diameter of 180 nm, disclosing to be biomaterial with nanocellulose dimensions.
31943376	7	6	theme	Scanning	991:998	arg1	microscopy					1009:1018	Scanning electron microscopy	991:1018	Scanning electron microscopy	991:1018	Scanning electron microscopy was performed on four samples, the original material, kraft pulp, and hydrolyzed biomaterials at 72 H in the ideal parameters.
31943376	1	7	theme	physical	173:180	arg1	characteristics					182:196	the physical characteristics	169:196	the physical characteristics of nanocellulose derived from Kraft pulp	169:237	Enzymatic hydrolysis processes can change the physical characteristics of nanocellulose derived from Kraft pulp.
31943376	0	8	theme	controlled	94:103	arg1	hydrolysis					115:124	controlled enzymatic hydrolysis	94:124	controlled enzymatic hydrolysis	94:124	Statistical analysis of the crystallinity index of nanocellulose produced from Kraft pulp via controlled enzymatic hydrolysis.
31943376	4	9	theme	statistical	552:562	arg1	analysis					564:571	statistical analysis	552:571	Central Composite Rotatable Design statistical analysis	517:571	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	7	10	theme	electron	1000:1007	arg1	microscopy					1009:1018	Scanning electron microscopy	991:1018	Scanning electron microscopy	991:1018	Scanning electron microscopy was performed on four samples, the original material, kraft pulp, and hydrolyzed biomaterials at 72 H in the ideal parameters.
31943376	7	11	theme	ideal	1129:1133	arg1	parameters					1135:1144	the ideal parameters	1125:1144	the ideal parameters	1125:1144	Scanning electron microscopy was performed on four samples, the original material, kraft pulp, and hydrolyzed biomaterials at 72 H in the ideal parameters.
31943376	4	12	theme	crystallinity	631:643	arg1	index					645:649	the crystallinity index	627:649	an increase the crystallinity index in 10% at the 24-H hydrolysis time	615:684	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	3	13	theme	crystallinity	451:463	arg1	index					465:469	the crystallinity index	447:469	the crystallinity index relative to its initial state	447:499	In this study, we determined the optimal conditions under which nanocellulose could be produced enzymatically with the greatest increase of the crystallinity index relative to its initial state.
31943376	3	14	theme	relative	471:478	arg1	index					465:469	the crystallinity index	447:469	the crystallinity index relative to its initial state	447:499	In this study, we determined the optimal conditions under which nanocellulose could be produced enzymatically with the greatest increase of the crystallinity index relative to its initial state.
31943376	0	15	theme	enzymatic	105:113	arg1	hydrolysis					115:124	controlled enzymatic hydrolysis	94:124	controlled enzymatic hydrolysis	94:124	Statistical analysis of the crystallinity index of nanocellulose produced from Kraft pulp via controlled enzymatic hydrolysis.
31943376	4	16	theme	Composite	525:533	arg1	Design					545:550	Central Composite Rotatable Design	517:550	Central Composite Rotatable Design statistical analysis	517:571	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	5	17	theme	24	805:806	arg1	times					796:800	hydrolysis times	785:800	hydrolysis times of 24, 48, and 72 H	785:820	Upon establishment of ideal levels of starting material and enzyme, reactions were carried out at hydrolysis times of 24, 48, and 72 H under these ideal parameters.
31943376	5	18	theme	72 H	817:820	arg1	times					796:800	hydrolysis times	785:800	hydrolysis times of 24, 48, and 72 H	785:820	Upon establishment of ideal levels of starting material and enzyme, reactions were carried out at hydrolysis times of 24, 48, and 72 H under these ideal parameters.
31943376	3	19	theme	optimal	340:346	arg1	conditions					348:357	the optimal conditions	336:357	the optimal conditions under which nanocellulose could be produced enzymatically with the greatest increase of the crystallinity index relative to its initial state	336:499	In this study, we determined the optimal conditions under which nanocellulose could be produced enzymatically with the greatest increase of the crystallinity index relative to its initial state.
31943376	7	20	theme	kraft	1074:1078	arg1	pulp					1080:1083	kraft pulp	1074:1083	kraft pulp	1074:1083	Scanning electron microscopy was performed on four samples, the original material, kraft pulp, and hydrolyzed biomaterials at 72 H in the ideal parameters.
31943376	1	21	theme	nanocellulose	201:213	arg1	characteristics					182:196	the physical characteristics	169:196	the physical characteristics of nanocellulose derived from Kraft pulp	169:237	Enzymatic hydrolysis processes can change the physical characteristics of nanocellulose derived from Kraft pulp.
31943376	0	22	theme	Statistical	0:10	arg1	analysis					12:19	Statistical analysis	0:19	Statistical analysis of the crystallinity index of nanocellulose	0:63	Statistical analysis of the crystallinity index of nanocellulose produced from Kraft pulp via controlled enzymatic hydrolysis.
31943376	4	23	from	time	681:684	arg1	increase					618:625	an increase	615:625	an increase the crystallinity index in 10% at the 24-H hydrolysis time	615:684	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	4	23	from	time	681:684	arg1	%					656:656	10%	654:656	10% at the 24-H hydrolysis time	654:684	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	3	24	theme	index	465:469	arg1	increase					435:442	the greatest increase	422:442	the greatest increase of the crystallinity index relative to its initial state	422:499	In this study, we determined the optimal conditions under which nanocellulose could be produced enzymatically with the greatest increase of the crystallinity index relative to its initial state.
31943376	8	25	theme	fiber	1215:1219	arg1	diameter					1221:1228	a fiber diameter	1213:1228	a fiber diameter of 180 nm	1213:1238	The hydrolyzed material with the best statistical data, revealing a fiber diameter of 180 nm, disclosing to be biomaterial with nanocellulose dimensions.
31943376	8	26	theme	statistical	1185:1195	arg1	data					1197:1200	the best statistical data	1176:1200	the best statistical data	1176:1200	The hydrolyzed material with the best statistical data, revealing a fiber diameter of 180 nm, disclosing to be biomaterial with nanocellulose dimensions.
31943376	5	27	theme	material	734:741	arg1	levels					715:720	ideal levels	709:720	ideal levels of starting material and enzyme	709:752	Upon establishment of ideal levels of starting material and enzyme, reactions were carried out at hydrolysis times of 24, 48, and 72 H under these ideal parameters.
31943376	5	28	theme	48	809:810	arg1	times					796:800	hydrolysis times	785:800	hydrolysis times of 24, 48, and 72 H	785:820	Upon establishment of ideal levels of starting material and enzyme, reactions were carried out at hydrolysis times of 24, 48, and 72 H under these ideal parameters.
31943376	4	29	theme	24-H	665:668	arg1	time					681:684	the 24-H hydrolysis time	661:684	the 24-H hydrolysis time	661:684	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	7	30	from	72 H	1117:1120	arg1	parameters					1135:1144	the ideal parameters	1125:1144	the ideal parameters	1125:1144	Scanning electron microscopy was performed on four samples, the original material, kraft pulp, and hydrolyzed biomaterials at 72 H in the ideal parameters.
31943376	7	31	theme	hydrolyzed	1090:1099	arg1	biomaterials					1101:1112	hydrolyzed biomaterials	1090:1112	hydrolyzed biomaterials	1090:1112	Scanning electron microscopy was performed on four samples, the original material, kraft pulp, and hydrolyzed biomaterials at 72 H in the ideal parameters.
31943376	1	32	theme	Kraft	228:232	arg1	pulp					234:237	Kraft pulp	228:237	Kraft pulp	228:237	Enzymatic hydrolysis processes can change the physical characteristics of nanocellulose derived from Kraft pulp.
31943376	0	33	theme	index	42:46	arg1	analysis					12:19	Statistical analysis	0:19	Statistical analysis of the crystallinity index of nanocellulose	0:63	Statistical analysis of the crystallinity index of nanocellulose produced from Kraft pulp via controlled enzymatic hydrolysis.
31943376	5	34	theme	enzyme	747:752	arg1	levels					715:720	ideal levels	709:720	ideal levels of starting material and enzyme	709:752	Upon establishment of ideal levels of starting material and enzyme, reactions were carried out at hydrolysis times of 24, 48, and 72 H under these ideal parameters.
31943376	6	35	theme	deagglomeration	873:887	arg1	effectiveness					856:868	The effectiveness	852:868	The effectiveness of deagglomeration	852:887	The effectiveness of deagglomeration was demonstrated by measuring the hydrodynamic diameter of the particles by dynamic light scattering.
31943376	0	36	theme	crystallinity	28:40	arg1	index					42:46	the crystallinity index	24:46	the crystallinity index of nanocellulose	24:63	Statistical analysis of the crystallinity index of nanocellulose produced from Kraft pulp via controlled enzymatic hydrolysis.
31943376	6	37	theme	light	973:977	arg1	scattering					979:988	dynamic light scattering	965:988	dynamic light scattering	965:988	The effectiveness of deagglomeration was demonstrated by measuring the hydrodynamic diameter of the particles by dynamic light scattering.
31943376	1	38	attach	derived	215:221	arg1	pulp					234:237	Kraft pulp	228:237	Kraft pulp	228:237	Enzymatic hydrolysis processes can change the physical characteristics of nanocellulose derived from Kraft pulp.
31943376	1	38	attach	derived	215:221	arg2	nanocellulose					201:213	nanocellulose	201:213	nanocellulose derived from Kraft pulp	201:237	Enzymatic hydrolysis processes can change the physical characteristics of nanocellulose derived from Kraft pulp.
31943376	4	39	theme	hydrolysis	670:679	arg1	time					681:684	the 24-H hydrolysis time	661:684	the 24-H hydrolysis time	661:684	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	0	40	theme	nanocellulose	51:63	arg1	index					42:46	the crystallinity index	24:46	the crystallinity index of nanocellulose	24:63	Statistical analysis of the crystallinity index of nanocellulose produced from Kraft pulp via controlled enzymatic hydrolysis.
31943376	6	41	theme	dynamic	965:971	arg1	scattering					979:988	dynamic light scattering	965:988	dynamic light scattering	965:988	The effectiveness of deagglomeration was demonstrated by measuring the hydrodynamic diameter of the particles by dynamic light scattering.
31943376	5	42	theme	ideal	709:713	arg1	levels					715:720	ideal levels	709:720	ideal levels of starting material and enzyme	709:752	Upon establishment of ideal levels of starting material and enzyme, reactions were carried out at hydrolysis times of 24, 48, and 72 H under these ideal parameters.
31943376	4	43	dep	increase	618:625	arg1	index					645:649	the crystallinity index	627:649	an increase the crystallinity index in 10% at the 24-H hydrolysis time	615:684	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	6	44	theme	hydrodynamic	923:934	arg1	diameter					936:943	the hydrodynamic diameter	919:943	the hydrodynamic diameter of the particles by dynamic light scattering	919:988	The effectiveness of deagglomeration was demonstrated by measuring the hydrodynamic diameter of the particles by dynamic light scattering.
31943376	4	45	dep	Design	545:550	arg1	analysis					564:571	statistical analysis	552:571	Central Composite Rotatable Design statistical analysis	517:571	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	5	46	theme	levels	715:720	arg1	establishment					692:704	establishment	692:704	establishment of ideal levels of starting material and enzyme	692:752	Upon establishment of ideal levels of starting material and enzyme, reactions were carried out at hydrolysis times of 24, 48, and 72 H under these ideal parameters.
31943376	1	47	theme	Enzymatic	127:135	arg1	processes					148:156	Enzymatic hydrolysis processes	127:156	Enzymatic hydrolysis processes	127:156	Enzymatic hydrolysis processes can change the physical characteristics of nanocellulose derived from Kraft pulp.
31943376	6	48	theme	particles	952:960	arg1	diameter					936:943	the hydrodynamic diameter	919:943	the hydrodynamic diameter of the particles by dynamic light scattering	919:988	The effectiveness of deagglomeration was demonstrated by measuring the hydrodynamic diameter of the particles by dynamic light scattering.
31943376	7	49	theme	original	1055:1062	arg1	material					1064:1071	the original material	1051:1071	the original material	1051:1071	Scanning electron microscopy was performed on four samples, the original material, kraft pulp, and hydrolyzed biomaterials at 72 H in the ideal parameters.
31943376	5	50	theme	hydrolysis	785:794	arg1	times					796:800	hydrolysis times	785:800	hydrolysis times of 24, 48, and 72 H	785:820	Upon establishment of ideal levels of starting material and enzyme, reactions were carried out at hydrolysis times of 24, 48, and 72 H under these ideal parameters.
31943376	1	51	theme	hydrolysis	137:146	arg1	processes					148:156	Enzymatic hydrolysis processes	127:156	Enzymatic hydrolysis processes	127:156	Enzymatic hydrolysis processes can change the physical characteristics of nanocellulose derived from Kraft pulp.
31943376	8	52	theme	best	1180:1183	arg1	data					1197:1200	the best statistical data	1176:1200	the best statistical data	1176:1200	The hydrolyzed material with the best statistical data, revealing a fiber diameter of 180 nm, disclosing to be biomaterial with nanocellulose dimensions.
31943376	5	53	theme	starting	725:732	arg1	material					734:741	starting material	725:741	starting material	725:741	Upon establishment of ideal levels of starting material and enzyme, reactions were carried out at hydrolysis times of 24, 48, and 72 H under these ideal parameters.
31943376	8	54	theme	180 nm	1233:1238	arg1	diameter					1221:1228	a fiber diameter	1213:1228	a fiber diameter of 180 nm	1213:1238	The hydrolyzed material with the best statistical data, revealing a fiber diameter of 180 nm, disclosing to be biomaterial with nanocellulose dimensions.
31943376	8	55	theme	hydrolyzed	1151:1160	arg1	material					1162:1169	The hydrolyzed material	1147:1169	The hydrolyzed material with the best statistical data, revealing a fiber diameter of 180 nm,	1147:1239	The hydrolyzed material with the best statistical data, revealing a fiber diameter of 180 nm, disclosing to be biomaterial with nanocellulose dimensions.
31943376	8	55	theme	hydrolyzed	1151:1160	arg1	biomaterial					1258:1268	biomaterial	1258:1268	biomaterial	1258:1268	The hydrolyzed material with the best statistical data, revealing a fiber diameter of 180 nm, disclosing to be biomaterial with nanocellulose dimensions.
31943376	3	56	theme	initial	487:493	arg1	state					495:499	its initial state	483:499	its initial state	483:499	In this study, we determined the optimal conditions under which nanocellulose could be produced enzymatically with the greatest increase of the crystallinity index relative to its initial state.
31943376	2	57	theme	crystallinity	271:283	arg1	index					285:289	its crystallinity index	267:289	its crystallinity index	267:289	Among these attributes are its crystallinity index and dimensions.
31943376	5	58	theme	ideal	834:838	arg1	parameters					840:849	these ideal parameters	828:849	these ideal parameters	828:849	Upon establishment of ideal levels of starting material and enzyme, reactions were carried out at hydrolysis times of 24, 48, and 72 H under these ideal parameters.
31943376	3	59	theme	greatest	426:433	arg1	increase					435:442	the greatest increase	422:442	the greatest increase of the crystallinity index relative to its initial state	422:499	In this study, we determined the optimal conditions under which nanocellulose could be produced enzymatically with the greatest increase of the crystallinity index relative to its initial state.
31943376	4	60	theme	Design	545:550	arg1	Application					502:512	Application	502:512	Application of Central Composite Rotatable Design statistical analysis to the experiments	502:590	Application of Central Composite Rotatable Design statistical analysis to the experiments was employed to direct an increase the crystallinity index in 10% at the 24-H hydrolysis time.
31943376	8	61	with	biomaterial	1258:1268	arg1	dimensions					1289:1298	nanocellulose dimensions	1275:1298	nanocellulose dimensions	1275:1298	The hydrolyzed material with the best statistical data, revealing a fiber diameter of 180 nm, disclosing to be biomaterial with nanocellulose dimensions.
32475575	0	0	theme	electrical	85:94	arg1	properties					96:105	improved physical and electrical properties	63:105	improved physical and electrical properties	63:105	Polypyrrole and cellulose nanofiber based composite films with improved physical and electrical properties for electromagnetic shielding applications.
32475575	2	1	theme	shielding	509:517	arg1	effectiveness					519:531	electromagnetic shielding effectiveness	493:531	electromagnetic shielding effectiveness (SE)	493:536	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	2	1	theme	shielding	509:517	arg1	SE					534:535	SE	534:535	SE	534:535	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	3	2	from	improvement	706:716	arg1	strength					750:757	tensile strength	742:757	tensile strength	742:757	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films was attributed to highly uniform and compact PPy coating and reduced porosity.
32475575	3	2	from	improvement	706:716	arg1	conductivity					721:732	conductivity	721:732	conductivity	721:732	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films was attributed to highly uniform and compact PPy coating and reduced porosity.
32475575	3	2	from	improvement	706:716	arg1	SE					735:736	SE	735:736	SE	735:736	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films was attributed to highly uniform and compact PPy coating and reduced porosity.
32475575	5	3	theme	new	1088:1090	arg1	approaches					1092:1101	These new approaches	1082:1101	These new approaches	1082:1101	These new approaches could enable a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications.
32475575	2	4	from	resistance	477:486	arg1	conductivity					439:450	the conductivity	435:450	the conductivity	435:450	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	1	5	theme	new	259:261	arg1	approaches					263:272	two new approaches	255:272	two new approaches	255:272	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	2	6	theme	electromagnetic	493:507	arg1	effectiveness					519:531	electromagnetic shielding effectiveness	493:531	electromagnetic shielding effectiveness (SE)	493:536	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	2	6	theme	electromagnetic	493:507	arg1	SE					534:535	SE	534:535	SE	534:535	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	1	7	theme	polyvinyl	348:356	arg1	alcohol					358:364	polyvinyl alcohol	348:364	polyvinyl alcohol	348:364	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	1	8	theme	cellulose	173:181	arg1	CNF					194:196	CNF	194:196	CNF	194:196	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	1	8	theme	cellulose	173:181	arg1	nanofiber					183:191	cellulose nanofiber	173:191	cellulose nanofiber (CNF)	173:197	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	4	9	theme	composite	1039:1047	arg1	films					1049:1053	PPy and CNF based composite films	1021:1053	PPy and CNF based composite films at a comparable thickness	1021:1079	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	3	10	theme	compact	833:839	arg1	coating					845:851	highly uniform and compact PPy coating	814:851	highly uniform and compact PPy coating	814:851	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films was attributed to highly uniform and compact PPy coating and reduced porosity.
32475575	2	11	from	strength	461:468	arg1	conductivity					439:450	the conductivity	435:450	the conductivity	435:450	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	2	12	theme	nanofiber	611:619	arg1	approach					627:634	commonly used in-situ nanofiber (ISF) approach	589:634	commonly used in-situ nanofiber (ISF) approach	589:634	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	5	13	theme	composite	1162:1170	arg1	films					1172:1176	flexible conducting composite films	1142:1176	flexible conducting composite films with superior physical and electrical properties for EMI shielding applications	1142:1256	These new approaches could enable a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications.
32475575	1	14	dep	Polypyrrole	151:161	arg1	films					226:230	based conducting composite films	199:230	based conducting composite films	199:230	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	4	15	theme	based	1033:1037	arg1	films					1049:1053	PPy and CNF based composite films	1021:1053	PPy and CNF based composite films at a comparable thickness	1021:1079	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	4	16	theme	strength	926:933	arg1	SE					875:876	SE	875:876	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films	875:968	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	4	16	theme	strength	926:933	arg1	values					986:991	the highest values	974:991	the highest values found in the literature for PPy and CNF based composite films at a comparable thickness	974:1079	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	1	17	theme	coated	366:371	arg1	PPy/PVA-CNP					394:404	PPy/PVA-CNP	394:404	PPy/PVA-CNP	394:404	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	1	17	theme	coated	366:371	arg1	nanopaper					383:391	coated cellulose nanopaper	366:391	coated cellulose nanopaper (PPy/PVA-CNP)	366:405	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	2	18	theme	in-situ	603:609	arg1	ISF					622:624	ISF	622:624	ISF	622:624	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	2	18	theme	in-situ	603:609	arg1	nanofiber					611:619	in-situ nanofiber	603:619	commonly used in-situ nanofiber (ISF) approach	589:634	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	3	19	theme	uniform	821:827	arg1	coating					845:851	highly uniform and compact PPy coating	814:851	highly uniform and compact PPy coating	814:851	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films was attributed to highly uniform and compact PPy coating and reduced porosity.
32475575	0	20	theme	shielding	127:135	arg1	applications					137:148	electromagnetic shielding applications	111:148	electromagnetic shielding applications	111:148	Polypyrrole and cellulose nanofiber based composite films with improved physical and electrical properties for electromagnetic shielding applications.
32475575	1	21	theme	cellulose	373:381	arg1	PPy/PVA-CNP					394:404	PPy/PVA-CNP	394:404	PPy/PVA-CNP	394:404	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	1	21	theme	cellulose	373:381	arg1	nanopaper					383:391	coated cellulose nanopaper	366:391	coated cellulose nanopaper (PPy/PVA-CNP)	366:405	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	5	22	theme	electrical	1205:1214	arg1	properties					1216:1225	superior physical and electrical properties	1183:1225	superior physical and electrical properties for EMI shielding applications	1183:1256	These new approaches could enable a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications.
32475575	4	23	theme	comparable	1060:1069	arg1	thickness					1071:1079	a comparable thickness	1058:1079	a comparable thickness	1058:1079	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	2	24	theme	Significant	408:418	arg1	improvement					420:430	Significant improvement	408:430	Significant improvement in the conductivity	408:450	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	0	25	theme	electromagnetic	111:125	arg1	applications					137:148	electromagnetic shielding applications	111:148	electromagnetic shielding applications	111:148	Polypyrrole and cellulose nanofiber based composite films with improved physical and electrical properties for electromagnetic shielding applications.
32475575	5	26	theme	superior	1183:1190	arg1	properties					1216:1225	superior physical and electrical properties	1183:1225	superior physical and electrical properties for EMI shielding applications	1183:1256	These new approaches could enable a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications.
32475575	2	27	theme	film	680:683	arg1	preparation					685:695	film preparation	680:695	film preparation	680:695	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	1	28	dep	nanopaper	324:332	arg1	PPy/PVA-CNP					394:404	PPy/PVA-CNP	394:404	PPy/PVA-CNP	394:404	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	1	28	dep	nanopaper	324:332	arg1	nanopaper					383:391	coated cellulose nanopaper	366:391	coated cellulose nanopaper (PPy/PVA-CNP)	366:405	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	5	29	theme	films	1172:1176	arg1	preparation					1127:1137	a scalable preparation	1116:1137	a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications	1116:1256	These new approaches could enable a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications.
32475575	1	30	dep	polymerization	283:296	arg1	in-situ					275:281	in-situ	275:281	in-situ	275:281	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	5	31	theme	conducting	1151:1160	arg1	films					1172:1176	flexible conducting composite films	1142:1176	flexible conducting composite films with superior physical and electrical properties for EMI shielding applications	1142:1256	These new approaches could enable a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications.
32475575	2	32	theme	prior	671:675	arg1	nanofibers					660:669	nanofibers	660:669	nanofibers prior to film preparation	660:695	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	2	33	theme	tensile	453:459	arg1	strength					461:468	tensile strength	453:468	tensile strength	453:468	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	4	34	located	found	993:997	arg1	literature					1006:1015	the literature	1002:1015	the literature for PPy and CNF based composite films at a comparable thickness	1002:1079	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	4	34	located	found	993:997	arg2	SE					875:876	SE	875:876	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films	875:968	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	4	34	located	found	993:997	arg2	values					986:991	the highest values	974:991	the highest values found in the literature for PPy and CNF based composite films at a comparable thickness	974:1079	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	1	35	theme	based	199:203	arg1	films					226:230	based conducting composite films	199:230	based conducting composite films	199:230	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	2	36	from	improvement	420:430	arg1	conductivity					439:450	the conductivity	435:450	the conductivity	435:450	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	1	37	theme	pyrrole	301:307	arg1	polymerization					283:296	polymerization	283:296	polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP)	283:405	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	2	38	theme	composite	561:569	arg1	films					571:575	these composite films	555:575	these composite films	555:575	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	1	39	theme	conducting	205:214	arg1	films					226:230	based conducting composite films	199:230	based conducting composite films	199:230	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	0	40	theme	composite	42:50	arg1	films					52:56	composite films	42:56	composite films with improved physical and electrical properties for electromagnetic shielding applications	42:148	Polypyrrole and cellulose nanofiber based composite films with improved physical and electrical properties for electromagnetic shielding applications.
32475575	3	41	theme	tensile	742:748	arg1	strength					750:757	tensile strength	742:757	tensile strength	742:757	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films was attributed to highly uniform and compact PPy coating and reduced porosity.
32475575	4	42	theme	tensile	918:924	arg1	strength					926:933	tensile strength	918:933	tensile strength of 103.8 MPa	918:946	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	1	43	theme	composite	216:224	arg1	films					226:230	based conducting composite films	199:230	based conducting composite films	199:230	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	4	44	theme	highest	978:984	arg1	SE					875:876	SE	875:876	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films	875:968	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	4	44	theme	highest	978:984	arg1	values					986:991	the highest values	974:991	the highest values found in the literature for PPy and CNF based composite films at a comparable thickness	974:1079	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	1	45	theme	cellulose	314:322	arg1	nanopaper					324:332	cellulose nanopaper	314:332	cellulose nanopaper (PPy/CNP)	314:342	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	1	45	theme	cellulose	314:322	arg1	PPy/CNP					335:341	PPy/CNP	335:341	PPy/CNP	335:341	Polypyrrole (PPy) and cellulose nanofiber (CNF) based conducting composite films were synthesized using two new approaches, in-situ polymerization of pyrrole onto cellulose nanopaper (PPy/CNP) and polyvinyl alcohol coated cellulose nanopaper (PPy/PVA-CNP).
32475575	5	46	theme	physical	1192:1199	arg1	properties					1216:1225	superior physical and electrical properties	1183:1225	superior physical and electrical properties for EMI shielding applications	1183:1256	These new approaches could enable a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications.
32475575	4	47	theme	PPy	1021:1023	arg1	films					1049:1053	PPy and CNF based composite films	1021:1053	PPy and CNF based composite films at a comparable thickness	1021:1079	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	4	48	theme	103.8 MPa	938:946	arg1	-23 dB					881:886	-23 dB	881:886	-23 dB (thickness upto 138.4 μm)	881:912	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	4	48	theme	103.8 MPa	938:946	arg1	strength					926:933	tensile strength	918:933	tensile strength of 103.8 MPa	918:946	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	4	48	theme	103.8 MPa	938:946	arg1	138.4 μm					904:911	thickness upto 138.4 μm	889:911	thickness upto 138.4 μm	889:911	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	3	49	theme	ISF	786:788	arg1	films					790:794	ISF films	786:794	ISF films	786:794	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films was attributed to highly uniform and compact PPy coating and reduced porosity.
32475575	2	50	theme	used	598:601	arg1	approach					627:634	commonly used in-situ nanofiber (ISF) approach	589:634	commonly used in-situ nanofiber (ISF) approach	589:634	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	2	51	from	effectiveness	519:531	arg1	conductivity					439:450	the conductivity	435:450	the conductivity	435:450	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	2	52	theme	water	471:475	arg1	resistance					477:486	water resistance	471:486	water resistance	471:486	Significant improvement in the conductivity, tensile strength, water resistance, and electromagnetic shielding effectiveness (SE) was observed for these composite films compared to commonly used in-situ nanofiber (ISF) approach, where PPy is coated on nanofibers prior to film preparation.
32475575	3	53	theme	PPy/PVA-CNP	762:772	arg1	strength					750:757	tensile strength	742:757	tensile strength	742:757	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films was attributed to highly uniform and compact PPy coating and reduced porosity.
32475575	3	53	theme	PPy/PVA-CNP	762:772	arg1	conductivity					721:732	conductivity	721:732	conductivity	721:732	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films was attributed to highly uniform and compact PPy coating and reduced porosity.
32475575	3	53	theme	PPy/PVA-CNP	762:772	arg1	SE					735:736	SE	735:736	SE	735:736	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films was attributed to highly uniform and compact PPy coating and reduced porosity.
32475575	4	54	theme	-23 dB	881:886	arg1	SE					875:876	SE	875:876	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films	875:968	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	4	54	theme	-23 dB	881:886	arg1	values					986:991	the highest values	974:991	the highest values found in the literature for PPy and CNF based composite films at a comparable thickness	974:1079	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	4	55	theme	PPy/PVA-CNP	952:962	arg1	films					964:968	PPy/PVA-CNP films	952:968	PPy/PVA-CNP films	952:968	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	5	56	theme	scalable	1118:1125	arg1	preparation					1127:1137	a scalable preparation	1116:1137	a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications	1116:1256	These new approaches could enable a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications.
32475575	5	57	theme	flexible	1142:1149	arg1	films					1172:1176	flexible conducting composite films	1142:1176	flexible conducting composite films with superior physical and electrical properties for EMI shielding applications	1142:1256	These new approaches could enable a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications.
32475575	4	58	theme	upto	899:902	arg1	-23 dB					881:886	-23 dB	881:886	-23 dB (thickness upto 138.4 μm)	881:912	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	4	58	theme	upto	899:902	arg1	138.4 μm					904:911	thickness upto 138.4 μm	889:911	thickness upto 138.4 μm	889:911	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	5	59	with	films	1172:1176	arg1	properties					1216:1225	superior physical and electrical properties	1183:1225	superior physical and electrical properties for EMI shielding applications	1183:1256	These new approaches could enable a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications.
32475575	0	60	dep	nanofiber	26:34	arg1	based					36:40	based	36:40	nanofiber based composite films with improved physical and electrical properties for electromagnetic shielding applications	26:148	Polypyrrole and cellulose nanofiber based composite films with improved physical and electrical properties for electromagnetic shielding applications.
32475575	3	61	theme	reduced	857:863	arg1	porosity					865:872	reduced porosity	857:872	reduced porosity	857:872	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films was attributed to highly uniform and compact PPy coating and reduced porosity.
32475575	4	62	theme	thickness	889:897	arg1	-23 dB					881:886	-23 dB	881:886	-23 dB (thickness upto 138.4 μm)	881:912	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	4	62	theme	thickness	889:897	arg1	138.4 μm					904:911	thickness upto 138.4 μm	889:911	thickness upto 138.4 μm	889:911	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	3	63	theme	PPy	841:843	arg1	coating					845:851	highly uniform and compact PPy coating	814:851	highly uniform and compact PPy coating	814:851	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films was attributed to highly uniform and compact PPy coating and reduced porosity.
32475575	0	64	theme	physical	72:79	arg1	properties					96:105	improved physical and electrical properties	63:105	improved physical and electrical properties	63:105	Polypyrrole and cellulose nanofiber based composite films with improved physical and electrical properties for electromagnetic shielding applications.
32475575	4	65	from	thickness	1071:1079	arg1	films					1049:1053	PPy and CNF based composite films	1021:1053	PPy and CNF based composite films at a comparable thickness	1021:1079	SE of -23 dB (thickness upto 138.4 μm) and tensile strength of 103.8 MPa for PPy/PVA-CNP films are the highest values found in the literature for PPy and CNF based composite films at a comparable thickness.
32475575	0	66	with	films	52:56	arg1	properties					96:105	improved physical and electrical properties	63:105	improved physical and electrical properties	63:105	Polypyrrole and cellulose nanofiber based composite films with improved physical and electrical properties for electromagnetic shielding applications.
32475575	5	67	theme	EMI	1231:1233	arg1	applications					1245:1256	EMI shielding applications	1231:1256	EMI shielding applications	1231:1256	These new approaches could enable a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications.
32475575	0	68	theme	improved	63:70	arg1	properties					96:105	improved physical and electrical properties	63:105	improved physical and electrical properties	63:105	Polypyrrole and cellulose nanofiber based composite films with improved physical and electrical properties for electromagnetic shielding applications.
32475575	3	69	theme	Maximum	698:704	arg1	improvement					706:716	Maximum improvement	698:716	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films	698:794	Maximum improvement in conductivity, SE and tensile strength of PPy/PVA-CNP compared to ISF films was attributed to highly uniform and compact PPy coating and reduced porosity.
32475575	5	70	theme	shielding	1235:1243	arg1	applications					1245:1256	EMI shielding applications	1231:1256	EMI shielding applications	1231:1256	These new approaches could enable a scalable preparation of flexible conducting composite films with superior physical and electrical properties for EMI shielding applications.
32829830	2	0	theme	%	453:453	arg1	loadings					440:447	different ANFs loadings	425:447	different ANFs loadings of 2%, 4%, 6% and 8%	425:468	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	1	1	theme	fiber	329:333	arg1	size					335:338	fiber size	329:338	fiber size	329:338	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	2	2	theme	homogeneous	527:537	arg1	mixing					539:544	homogeneous mixing	527:544	homogeneous mixing	527:544	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	3	3	theme	increased	618:626	arg1	strength					636:643	the increased tensile strength	614:643	the increased tensile strength	614:643	The achieved membranes with relatively low ANFs loadings exhibited the increased tensile strength and ionic conductivity.
32829830	2	4	theme	paper-making	501:512	arg1	method					514:519	a traditional paper-making method	487:519	a traditional paper-making method	487:519	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	1	5	theme	BC	264:265	arg1	membranes					268:276	bacterial cellulose (BC) membranes	243:276	bacterial cellulose (BC) membranes	243:276	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	2	6	theme	%	461:461	arg1	loadings					440:447	different ANFs loadings	425:447	different ANFs loadings of 2%, 4%, 6% and 8%	425:468	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	3	7	theme	tensile	628:634	arg1	strength					636:643	the increased tensile strength	614:643	the increased tensile strength	614:643	The achieved membranes with relatively low ANFs loadings exhibited the increased tensile strength and ionic conductivity.
32829830	4	8	theme	2	708:708	arg1	%					709:709	%	709:709	%	709:709	The Li/LiFePO4 half-cells based on the 2%ANFs/BC separator demonstrated the best electrochemical performance (including discharge capacity, C-rate capability and cycling stability).
32829830	1	9	from	bonding	308:314	arg1	ANFs					371:374	ANFs	371:374	ANFs	371:374	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	1	10	theme	Aramid	85:90	arg1	nanofibers					92:101	Aramid nanofibers	85:101	Aramid nanofibers (ANFs)	85:108	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	1	10	theme	Aramid	85:90	arg1	blocks					158:163	new nanoscale building blocks	135:163	new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs	135:374	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	1	10	theme	Aramid	85:90	arg1	ANFs					104:107	ANFs	104:107	ANFs	104:107	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	1	11	theme	membranes	268:276	arg1	performance					205:215	the mechanical performance	190:215	the mechanical performance	190:215	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	1	11	theme	membranes	268:276	arg1	conductivity					227:238	ionic conductivity	221:238	ionic conductivity of bacterial cellulose (BC) membranes	221:276	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	1	12	theme	polar	348:352	arg1	groups					361:366	the polar aramid groups	344:366	the polar aramid groups in ANFs	344:374	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	4	13	theme	ANFs/BC	710:716	arg1	separator					718:726	the 2%ANFs/BC separator	704:726	the 2%ANFs/BC separator	704:726	The Li/LiFePO4 half-cells based on the 2%ANFs/BC separator demonstrated the best electrochemical performance (including discharge capacity, C-rate capability and cycling stability).
32829830	4	14	dep	performance	766:776	arg1	including					779:787	including	779:787	including discharge capacity, C-rate capability and cycling stability	779:847	The Li/LiFePO4 half-cells based on the 2%ANFs/BC separator demonstrated the best electrochemical performance (including discharge capacity, C-rate capability and cycling stability).
32829830	2	15	theme	%	457:457	arg1	loadings					440:447	different ANFs loadings	425:447	different ANFs loadings of 2%, 4%, 6% and 8%	425:468	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	1	16	theme	aramid	354:359	arg1	groups					361:366	the polar aramid groups	344:366	the polar aramid groups in ANFs	344:374	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	4	17	theme	discharge	789:797	arg1	capacity					799:806	discharge capacity	789:806	discharge capacity	789:806	The Li/LiFePO4 half-cells based on the 2%ANFs/BC separator demonstrated the best electrochemical performance (including discharge capacity, C-rate capability and cycling stability).
32829830	1	18	from	groups	361:366	arg1	ANFs					371:374	ANFs	371:374	ANFs	371:374	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	0	19	theme	nanofiber/bacterial	7:25	arg1	separators					47:56	Aramid nanofiber/bacterial cellulose composite separators	0:56	Aramid nanofiber/bacterial cellulose composite separators for lithium-ion batteries.	0:83	Aramid nanofiber/bacterial cellulose composite separators for lithium-ion batteries.
32829830	2	20	with	membranes	395:403	arg1	loadings					440:447	different ANFs loadings	425:447	different ANFs loadings of 2%, 4%, 6% and 8%	425:468	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	4	21	theme	C-rate	809:814	arg1	capability					816:825	C-rate capability	809:825	C-rate capability	809:825	The Li/LiFePO4 half-cells based on the 2%ANFs/BC separator demonstrated the best electrochemical performance (including discharge capacity, C-rate capability and cycling stability).
32829830	0	22	theme	Aramid	0:5	arg1	separators					47:56	Aramid nanofiber/bacterial cellulose composite separators	0:56	Aramid nanofiber/bacterial cellulose composite separators for lithium-ion batteries.	0:83	Aramid nanofiber/bacterial cellulose composite separators for lithium-ion batteries.
32829830	4	23	theme	Li/LiFePO4	673:682	arg1	half-cells					684:693	The Li/LiFePO4 half-cells	669:693	The Li/LiFePO4 half-cells based on the 2%ANFs/BC separator	669:726	The Li/LiFePO4 half-cells based on the 2%ANFs/BC separator demonstrated the best electrochemical performance (including discharge capacity, C-rate capability and cycling stability).
32829830	3	24	with	membranes	560:568	arg1	loadings					595:602	relatively low ANFs loadings	575:602	relatively low ANFs loadings	575:602	The achieved membranes with relatively low ANFs loadings exhibited the increased tensile strength and ionic conductivity.
32829830	0	25	theme	composite	37:45	arg1	separators					47:56	Aramid nanofiber/bacterial cellulose composite separators	0:56	Aramid nanofiber/bacterial cellulose composite separators for lithium-ion batteries.	0:83	Aramid nanofiber/bacterial cellulose composite separators for lithium-ion batteries.
32829830	5	26	theme	promising	895:903	arg1	candidate					905:913	a promising candidate	893:913	a promising candidate for high-performance Li-ion batteries	893:951	Thus, the proposed ANFs/BC separators are a promising candidate for high-performance Li-ion batteries.
32829830	5	26	theme	promising	895:903	arg1	separators					878:887	the proposed ANFs/BC separators	857:887	the proposed ANFs/BC separators	857:887	Thus, the proposed ANFs/BC separators are a promising candidate for high-performance Li-ion batteries.
32829830	1	27	theme	mechanical	194:203	arg1	performance					205:215	the mechanical performance	190:215	the mechanical performance	190:215	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	0	28	theme	cellulose	27:35	arg1	separators					47:56	Aramid nanofiber/bacterial cellulose composite separators	0:56	Aramid nanofiber/bacterial cellulose composite separators for lithium-ion batteries.	0:83	Aramid nanofiber/bacterial cellulose composite separators for lithium-ion batteries.
32829830	2	29	theme	%	468:468	arg1	loadings					440:447	different ANFs loadings	425:447	different ANFs loadings of 2%, 4%, 6% and 8%	425:468	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	1	30	theme	high	291:294	arg1	bonding					308:314	their high interfacial bonding	285:314	their high interfacial bonding	285:314	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	3	31	theme	low	586:588	arg1	loadings					595:602	relatively low ANFs loadings	575:602	relatively low ANFs loadings	575:602	The achieved membranes with relatively low ANFs loadings exhibited the increased tensile strength and ionic conductivity.
32829830	2	32	theme	composite	385:393	arg1	membranes					395:403	composite membranes	385:403	composite membranes of BC	385:409	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	1	33	theme	interfacial	296:306	arg1	bonding					308:314	their high interfacial bonding	285:314	their high interfacial bonding	285:314	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	4	34	theme	electrochemical	750:764	arg1	performance					766:776	electrochemical performance	750:776	the best electrochemical performance (including discharge capacity, C-rate capability and cycling stability)	741:848	The Li/LiFePO4 half-cells based on the 2%ANFs/BC separator demonstrated the best electrochemical performance (including discharge capacity, C-rate capability and cycling stability).
32829830	1	35	theme	ionic	221:225	arg1	conductivity					227:238	ionic conductivity	221:238	ionic conductivity of bacterial cellulose (BC) membranes	221:276	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	2	36	theme	ANFs	435:438	arg1	loadings					440:447	different ANFs loadings	425:447	different ANFs loadings of 2%, 4%, 6% and 8%	425:468	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	2	37	theme	traditional	489:499	arg1	method					514:519	a traditional paper-making method	487:519	a traditional paper-making method	487:519	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	5	38	theme	high-performance	919:934	arg1	batteries					943:951	high-performance Li-ion batteries	919:951	high-performance Li-ion batteries	919:951	Thus, the proposed ANFs/BC separators are a promising candidate for high-performance Li-ion batteries.
32829830	3	39	theme	ionic	649:653	arg1	conductivity					655:666	ionic conductivity	649:666	ionic conductivity	649:666	The achieved membranes with relatively low ANFs loadings exhibited the increased tensile strength and ionic conductivity.
32829830	0	40	theme	lithium-ion	62:72	arg1	batteries					74:82	lithium-ion batteries	62:82	lithium-ion batteries	62:82	Aramid nanofiber/bacterial cellulose composite separators for lithium-ion batteries.
32829830	2	41	theme	different	425:433	arg1	loadings					440:447	different ANFs loadings	425:447	different ANFs loadings of 2%, 4%, 6% and 8%	425:468	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	5	42	theme	proposed	861:868	arg1	candidate					905:913	a promising candidate	893:913	a promising candidate for high-performance Li-ion batteries	893:951	Thus, the proposed ANFs/BC separators are a promising candidate for high-performance Li-ion batteries.
32829830	5	42	theme	proposed	861:868	arg1	separators					878:887	the proposed ANFs/BC separators	857:887	the proposed ANFs/BC separators	857:887	Thus, the proposed ANFs/BC separators are a promising candidate for high-performance Li-ion batteries.
32829830	2	43	with	ANFs	415:418	arg1	loadings					440:447	different ANFs loadings	425:447	different ANFs loadings of 2%, 4%, 6% and 8%	425:468	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	5	44	theme	ANFs/BC	870:876	arg1	candidate					905:913	a promising candidate	893:913	a promising candidate for high-performance Li-ion batteries	893:951	Thus, the proposed ANFs/BC separators are a promising candidate for high-performance Li-ion batteries.
32829830	5	44	theme	ANFs/BC	870:876	arg1	separators					878:887	the proposed ANFs/BC separators	857:887	the proposed ANFs/BC separators	857:887	Thus, the proposed ANFs/BC separators are a promising candidate for high-performance Li-ion batteries.
32829830	4	45	theme	%	709:709	arg1	separator					718:726	the 2%ANFs/BC separator	704:726	the 2%ANFs/BC separator	704:726	The Li/LiFePO4 half-cells based on the 2%ANFs/BC separator demonstrated the best electrochemical performance (including discharge capacity, C-rate capability and cycling stability).
32829830	3	46	theme	ANFs	590:593	arg1	loadings					595:602	relatively low ANFs loadings	575:602	relatively low ANFs loadings	575:602	The achieved membranes with relatively low ANFs loadings exhibited the increased tensile strength and ionic conductivity.
32829830	3	47	theme	achieved	551:558	arg1	membranes					560:568	The achieved membranes	547:568	The achieved membranes with relatively low ANFs loadings	547:602	The achieved membranes with relatively low ANFs loadings exhibited the increased tensile strength and ionic conductivity.
32829830	1	48	theme	new	135:137	arg1	nanofibers					92:101	Aramid nanofibers	85:101	Aramid nanofibers (ANFs)	85:108	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	1	48	theme	new	135:137	arg1	blocks					158:163	new nanoscale building blocks	135:163	new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs	135:374	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	4	49	theme	cycling	831:837	arg1	stability					839:847	cycling stability	831:847	cycling stability	831:847	The Li/LiFePO4 half-cells based on the 2%ANFs/BC separator demonstrated the best electrochemical performance (including discharge capacity, C-rate capability and cycling stability).
32829830	5	50	theme	Li-ion	936:941	arg1	batteries					943:951	high-performance Li-ion batteries	919:951	high-performance Li-ion batteries	919:951	Thus, the proposed ANFs/BC separators are a promising candidate for high-performance Li-ion batteries.
32829830	4	51	theme	best	745:748	arg1	performance					766:776	electrochemical performance	750:776	the best electrochemical performance (including discharge capacity, C-rate capability and cycling stability)	741:848	The Li/LiFePO4 half-cells based on the 2%ANFs/BC separator demonstrated the best electrochemical performance (including discharge capacity, C-rate capability and cycling stability).
32829830	1	52	theme	nanoscale	139:147	arg1	nanofibers					92:101	Aramid nanofibers	85:101	Aramid nanofibers (ANFs)	85:108	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	1	52	theme	nanoscale	139:147	arg1	blocks					158:163	new nanoscale building blocks	135:163	new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs	135:374	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	1	53	theme	bacterial	243:251	arg1	membranes					268:276	bacterial cellulose (BC) membranes	243:276	bacterial cellulose (BC) membranes	243:276	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	2	54	theme	BC	408:409	arg1	ANFs					415:418	ANFs	415:418	ANFs with different ANFs loadings of 2%, 4%, 6% and 8%	415:468	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	2	54	theme	BC	408:409	arg1	membranes					395:403	composite membranes	385:403	composite membranes of BC	385:409	Herein, composite membranes of BC and ANFs with different ANFs loadings of 2%, 4%, 6% and 8% were prepared by a traditional paper-making method after homogeneous mixing.
32829830	1	55	theme	building	149:156	arg1	nanofibers					92:101	Aramid nanofibers	85:101	Aramid nanofibers (ANFs)	85:108	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	1	55	theme	building	149:156	arg1	blocks					158:163	new nanoscale building blocks	135:163	new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs	135:374	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
32829830	1	56	theme	cellulose	253:261	arg1	membranes					268:276	bacterial cellulose (BC) membranes	243:276	bacterial cellulose (BC) membranes	243:276	Aramid nanofibers (ANFs) are expected to serve as new nanoscale building blocks which could improve both the mechanical performance and ionic conductivity of bacterial cellulose (BC) membranes due to their high interfacial bonding, matching of fiber size and the polar aramid groups in ANFs.
34118669	0	0	theme	interaction	81:91	arg1	Influence					61:69	Influence	61:69	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.	0:139	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.
34118669	1	1	theme	abundant	333:340	arg1	functionalities					360:374	the abundant oxygen-containing functionalities	329:374	the abundant oxygen-containing functionalities	329:374	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	5	2	theme	fragments	905:913	arg1	stability					888:896	the stability	884:896	the stability of the fragments from hydrolysis of swine manure	884:945	This was because the cellulose-derived intermediates favored the stability of the fragments from hydrolysis of swine manure.
34118669	9	3	from	formation	1581:1589	arg1	ways					1686:1689	distinct ways	1677:1689	distinct ways	1677:1689	The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.
34118669	6	4	theme	yield	1017:1021	arg1	reduction					990:998	the reduction	986:998	the reduction of the hydrochar yield	986:1021	The increased temperature resulted in the reduction of the hydrochar yield whereas the prolonged time enhanced the formation of solid product.
34118669	0	5	theme	mutual	74:79	arg1	interaction					81:91	mutual interaction	74:91	mutual interaction of intermediates	74:108	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.
34118669	1	6	theme	oxygen-containing	342:358	arg1	functionalities					360:374	the abundant oxygen-containing functionalities	329:374	the abundant oxygen-containing functionalities	329:374	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	5	7	link	cellulose-derived	844:860	arg1	intermediates					862:874	the cellulose-derived intermediates	840:874	the cellulose-derived intermediates	840:874	This was because the cellulose-derived intermediates favored the stability of the fragments from hydrolysis of swine manure.
34118669	1	8	with	intermediates	310:322	arg1	functionalities					360:374	the abundant oxygen-containing functionalities	329:374	the abundant oxygen-containing functionalities	329:374	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	9	9	theme	intermediates	1549:1561	arg1	interaction					1523:1533	The interaction	1519:1533	The interaction of the varied intermediates	1519:1561	The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.
34118669	1	10	theme	hydrochar	250:258	arg1	properties					232:241	the fuel properties	223:241	the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities	223:374	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	0	11	theme	intermediates	96:108	arg1	interaction					81:91	mutual interaction	74:91	mutual interaction of intermediates	74:108	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.
34118669	7	12	theme	intermediates	1121:1133	arg1	interaction					1095:1105	The interaction	1091:1105	The interaction of the co-HTC intermediates	1091:1133	The interaction of the co-HTC intermediates facilitated the formation of O-containing species, thus making the solid more oxygen- and hydrogen-rich with a higher volatility.
34118669	9	13	theme	acids	1622:1626	arg1	formation					1581:1589	the formation	1577:1589	the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways	1577:1689	The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.
34118669	8	14	theme	thermal	1358:1364	arg1	treatment					1366:1374	the thermal treatment	1354:1374	the thermal treatment of the hydrochar	1354:1391	In addition, the co-HTC affected the evolution of functionalities like -OH and CO during the thermal treatment of the hydrochar and altered its morphology by stuffing the pores from swine manure-derived solid with the microspheres from HTC of cellulose.
34118669	9	15	theme	ketones	1602:1608	arg1	formation					1581:1589	the formation	1577:1589	the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways	1577:1689	The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.
34118669	1	16	theme	due	260:262	arg1	hydrochar					250:258	the hydrochar	246:258	the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities	246:374	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	8	17	from	HTC	1501:1503	arg1	microspheres					1483:1494	the microspheres	1479:1494	the microspheres from HTC of cellulose	1479:1516	In addition, the co-HTC affected the evolution of functionalities like -OH and CO during the thermal treatment of the hydrochar and altered its morphology by stuffing the pores from swine manure-derived solid with the microspheres from HTC of cellulose.
34118669	7	18	theme	species	1177:1183	arg1	formation					1151:1159	the formation	1147:1159	the formation of O-containing species	1147:1183	The interaction of the co-HTC intermediates facilitated the formation of O-containing species, thus making the solid more oxygen- and hydrogen-rich with a higher volatility.
34118669	9	19	theme	varied	1542:1547	arg1	intermediates					1549:1561	the varied intermediates	1538:1561	the varied intermediates	1538:1561	The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.
34118669	8	20	theme	functionalities	1315:1329	arg1	evolution					1302:1310	the evolution	1298:1310	the evolution of functionalities like -OH and CO	1298:1345	In addition, the co-HTC affected the evolution of functionalities like -OH and CO during the thermal treatment of the hydrochar and altered its morphology by stuffing the pores from swine manure-derived solid with the microspheres from HTC of cellulose.
34118669	9	21	theme	distinct	1677:1684	arg1	ways					1686:1689	distinct ways	1677:1689	distinct ways	1677:1689	The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.
34118669	3	22	used	used	563:566	arg2	cellulose					549:557	cellulose	549:557	cellulose	549:557	In this study, cellulose was used for co-HTC with swine manure to investigate the influence on the properties of the hydrochar.
34118669	3	23	from	influence	616:624	arg1	properties					633:642	the properties	629:642	the properties of the hydrochar	629:659	In this study, cellulose was used for co-HTC with swine manure to investigate the influence on the properties of the hydrochar.
34118669	4	24	theme	theoretical	804:814	arg1	value					816:820	the theoretical value	800:820	the theoretical value	800:820	The yield of hydrochar obtained from co-HTC reduced gradually with the cellulose proportion increased, and the solid yield was lower than the theoretical value.
34118669	2	25	theme	individual	471:480	arg1	components					482:491	the individual components	467:491	the individual components of biomass	467:502	However, the complicated compositions make it difficult to explicit the specific roles of the individual components of biomass played in the co-HTC process.
34118669	7	26	theme	co-HTC	1114:1119	arg1	intermediates					1121:1133	the co-HTC intermediates	1110:1133	the co-HTC intermediates	1110:1133	The interaction of the co-HTC intermediates facilitated the formation of O-containing species, thus making the solid more oxygen- and hydrogen-rich with a higher volatility.
34118669	4	27	theme	solid	773:777	arg1	lower					789:793	lower	789:793	lower	789:793	The yield of hydrochar obtained from co-HTC reduced gradually with the cellulose proportion increased, and the solid yield was lower than the theoretical value.
34118669	4	27	theme	solid	773:777	arg1	yield					779:783	the solid yield	769:783	the solid yield	769:783	The yield of hydrochar obtained from co-HTC reduced gradually with the cellulose proportion increased, and the solid yield was lower than the theoretical value.
34118669	9	28	theme	polymeric	1655:1663	arg1	products					1665:1672	the polymeric products	1651:1672	the polymeric products	1651:1672	The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.
34118669	7	29	theme	higher	1246:1251	arg1	volatility					1253:1262	a higher volatility	1244:1262	a higher volatility	1244:1262	The interaction of the co-HTC intermediates facilitated the formation of O-containing species, thus making the solid more oxygen- and hydrogen-rich with a higher volatility.
34118669	8	30	theme	hydrochar	1383:1391	arg1	treatment					1366:1374	the thermal treatment	1354:1374	the thermal treatment of the hydrochar	1354:1391	In addition, the co-HTC affected the evolution of functionalities like -OH and CO during the thermal treatment of the hydrochar and altered its morphology by stuffing the pores from swine manure-derived solid with the microspheres from HTC of cellulose.
34118669	6	31	theme	product	1082:1088	arg1	formation					1063:1071	the formation	1059:1071	the formation of solid product	1059:1088	The increased temperature resulted in the reduction of the hydrochar yield whereas the prolonged time enhanced the formation of solid product.
34118669	1	32	theme	livestock	180:188	arg1	manure					190:195	livestock manure	180:195	livestock manure	180:195	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	0	33	theme	Co-hydrothermal	0:14	arg1	carbonization					16:28	Co-hydrothermal carbonization	0:28	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.	0:139	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.
34118669	5	34	from	hydrolysis	920:929	arg1	fragments					905:913	the fragments	901:913	the fragments from hydrolysis of swine manure	901:945	This was because the cellulose-derived intermediates favored the stability of the fragments from hydrolysis of swine manure.
34118669	5	34	from	hydrolysis	920:929	arg1	stability					888:896	the stability	884:896	the stability of the fragments from hydrolysis of swine manure	884:945	This was because the cellulose-derived intermediates favored the stability of the fragments from hydrolysis of swine manure.
34118669	4	35	theme	cellulose	733:741	arg1	proportion					743:752	the cellulose proportion	729:752	the cellulose proportion increased	729:762	The yield of hydrochar obtained from co-HTC reduced gradually with the cellulose proportion increased, and the solid yield was lower than the theoretical value.
34118669	1	36	theme	manure	190:195	arg1	carbonization					157:169	Co-hydrothermal carbonization	141:169	Co-hydrothermal carbonization (HTC) of livestock manure and biomass	141:207	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	1	36	theme	manure	190:195	arg1	HTC					172:174	HTC	172:174	HTC	172:174	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	0	37	theme	swine	33:37	arg1	manure					39:44	swine manure	33:44	swine manure	33:44	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.
34118669	1	38	theme	high	271:274	arg1	reactivity					276:285	the high reactivity	267:285	the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities	267:374	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	8	39	from	solid	1468:1472	arg1	pores					1436:1440	the pores	1432:1440	the pores from swine manure-derived solid with the microspheres from HTC of cellulose	1432:1516	In addition, the co-HTC affected the evolution of functionalities like -OH and CO during the thermal treatment of the hydrochar and altered its morphology by stuffing the pores from swine manure-derived solid with the microspheres from HTC of cellulose.
34118669	8	40	link	manure-derived	1453:1466	arg1	solid					1468:1472	solid	1468:1472	solid	1468:1472	In addition, the co-HTC affected the evolution of functionalities like -OH and CO during the thermal treatment of the hydrochar and altered its morphology by stuffing the pores from swine manure-derived solid with the microspheres from HTC of cellulose.
34118669	2	41	theme	specific	449:456	arg1	roles					458:462	the specific roles	445:462	the specific roles of the individual components of biomass played in the co-HTC process	445:531	However, the complicated compositions make it difficult to explicit the specific roles of the individual components of biomass played in the co-HTC process.
34118669	9	42	theme	amines	1594:1599	arg1	formation					1581:1589	the formation	1577:1589	the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways	1577:1689	The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.
34118669	1	43	theme	biomass	201:207	arg1	carbonization					157:169	Co-hydrothermal carbonization	141:169	Co-hydrothermal carbonization (HTC) of livestock manure and biomass	141:207	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	1	43	theme	biomass	201:207	arg1	HTC					172:174	HTC	172:174	HTC	172:174	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	2	44	theme	biomass	496:502	arg1	components					482:491	the individual components	467:491	the individual components of biomass	467:502	However, the complicated compositions make it difficult to explicit the specific roles of the individual components of biomass played in the co-HTC process.
34118669	3	45	theme	hydrochar	651:659	arg1	properties					633:642	the properties	629:642	the properties of the hydrochar	629:659	In this study, cellulose was used for co-HTC with swine manure to investigate the influence on the properties of the hydrochar.
34118669	9	46	theme	carboxylic	1611:1620	arg1	acids					1622:1626	carboxylic acids	1611:1626	carboxylic acids	1611:1626	The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.
34118669	2	47	theme	complicated	390:400	arg1	compositions					402:413	the complicated compositions	386:413	the complicated compositions	386:413	However, the complicated compositions make it difficult to explicit the specific roles of the individual components of biomass played in the co-HTC process.
34118669	0	48	theme	manure	39:44	arg1	carbonization					16:28	Co-hydrothermal carbonization	0:28	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.	0:139	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.
34118669	0	49	theme	products	131:138	arg1	properties					113:122	properties	113:122	properties of the products	113:138	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.
34118669	6	50	theme	hydrochar	1007:1015	arg1	yield					1017:1021	the hydrochar yield	1003:1021	the hydrochar yield	1003:1021	The increased temperature resulted in the reduction of the hydrochar yield whereas the prolonged time enhanced the formation of solid product.
34118669	3	51	with	co-HTC	572:577	arg1	manure					590:595	swine manure	584:595	swine manure	584:595	In this study, cellulose was used for co-HTC with swine manure to investigate the influence on the properties of the hydrochar.
34118669	5	52	theme	cellulose-derived	844:860	arg1	intermediates					862:874	the cellulose-derived intermediates	840:874	the cellulose-derived intermediates	840:874	This was because the cellulose-derived intermediates favored the stability of the fragments from hydrolysis of swine manure.
34118669	2	53	theme	components	482:491	arg1	roles					458:462	the specific roles	445:462	the specific roles of the individual components of biomass played in the co-HTC process	445:531	However, the complicated compositions make it difficult to explicit the specific roles of the individual components of biomass played in the co-HTC process.
34118669	1	54	theme	biomass-derived	294:308	arg1	intermediates					310:322	the biomass-derived intermediates	290:322	the biomass-derived intermediates with the abundant oxygen-containing functionalities	290:374	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	0	55	from	Influence	61:69	arg1	properties					113:122	properties	113:122	properties of the products	113:138	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.
34118669	3	56	theme	swine	584:588	arg1	manure					590:595	swine manure	584:595	swine manure	584:595	In this study, cellulose was used for co-HTC with swine manure to investigate the influence on the properties of the hydrochar.
34118669	0	57	theme	cellulose	50:58	arg1	carbonization					16:28	Co-hydrothermal carbonization	0:28	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.	0:139	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.
34118669	1	58	theme	intermediates	310:322	arg1	reactivity					276:285	the high reactivity	267:285	the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities	267:374	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	9	59	theme	aromatics	1637:1645	arg1	formation					1581:1589	the formation	1577:1589	the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways	1577:1689	The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.
34118669	9	60	theme	products	1665:1672	arg1	formation					1581:1589	the formation	1577:1589	the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways	1577:1689	The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.
34118669	6	61	theme	prolonged	1035:1043	arg1	time					1045:1048	the prolonged time	1031:1048	the prolonged time	1031:1048	The increased temperature resulted in the reduction of the hydrochar yield whereas the prolonged time enhanced the formation of solid product.
34118669	8	62	with	solid	1468:1472	arg1	microspheres					1483:1494	the microspheres	1479:1494	the microspheres from HTC of cellulose	1479:1516	In addition, the co-HTC affected the evolution of functionalities like -OH and CO during the thermal treatment of the hydrochar and altered its morphology by stuffing the pores from swine manure-derived solid with the microspheres from HTC of cellulose.
34118669	9	63	theme	esters	1629:1634	arg1	formation					1581:1589	the formation	1577:1589	the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways	1577:1689	The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.
34118669	7	64	theme	O-containing	1164:1175	arg1	species					1177:1183	O-containing species	1164:1183	O-containing species	1164:1183	The interaction of the co-HTC intermediates facilitated the formation of O-containing species, thus making the solid more oxygen- and hydrogen-rich with a higher volatility.
34118669	1	65	link	biomass-derived	294:308	arg1	intermediates					310:322	the biomass-derived intermediates	290:322	the biomass-derived intermediates with the abundant oxygen-containing functionalities	290:374	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	5	66	theme	swine	934:938	arg1	manure					940:945	swine manure	934:945	swine manure	934:945	This was because the cellulose-derived intermediates favored the stability of the fragments from hydrolysis of swine manure.
34118669	6	67	theme	solid	1076:1080	arg1	product					1082:1088	solid product	1076:1088	solid product	1076:1088	The increased temperature resulted in the reduction of the hydrochar yield whereas the prolonged time enhanced the formation of solid product.
34118669	8	68	theme	cellulose	1508:1516	arg1	HTC					1501:1503	HTC	1501:1503	HTC of cellulose	1501:1516	In addition, the co-HTC affected the evolution of functionalities like -OH and CO during the thermal treatment of the hydrochar and altered its morphology by stuffing the pores from swine manure-derived solid with the microspheres from HTC of cellulose.
34118669	5	69	theme	manure	940:945	arg1	hydrolysis					920:929	hydrolysis	920:929	hydrolysis of swine manure	920:945	This was because the cellulose-derived intermediates favored the stability of the fragments from hydrolysis of swine manure.
34118669	1	70	theme	fuel	227:230	arg1	properties					232:241	the fuel properties	223:241	the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities	223:374	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	2	71	theme	co-HTC	518:523	arg1	process					525:531	the co-HTC process	514:531	the co-HTC process	514:531	However, the complicated compositions make it difficult to explicit the specific roles of the individual components of biomass played in the co-HTC process.
34118669	0	72	dep	carbonization	16:28	arg1	Influence					61:69	Influence	61:69	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.	0:139	Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.
34118669	5	73	from	stability	888:896	arg1	hydrolysis					920:929	hydrolysis	920:929	hydrolysis of swine manure	920:945	This was because the cellulose-derived intermediates favored the stability of the fragments from hydrolysis of swine manure.
34118669	1	74	theme	Co-hydrothermal	141:155	arg1	carbonization					157:169	Co-hydrothermal carbonization	141:169	Co-hydrothermal carbonization (HTC) of livestock manure and biomass	141:207	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	1	74	theme	Co-hydrothermal	141:155	arg1	HTC					172:174	HTC	172:174	HTC	172:174	Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities.
34118669	4	75	theme	hydrochar	675:683	arg1	yield					666:670	The yield	662:670	The yield of hydrochar obtained from co-HTC	662:704	The yield of hydrochar obtained from co-HTC reduced gradually with the cellulose proportion increased, and the solid yield was lower than the theoretical value.
34118669	7	76	theme	solid	1202:1206	arg1	oxygen-					1213:1219	oxygen-	1213:1219	oxygen-	1213:1219	The interaction of the co-HTC intermediates facilitated the formation of O-containing species, thus making the solid more oxygen- and hydrogen-rich with a higher volatility.
34118669	6	77	theme	increased	952:960	arg1	temperature					962:972	The increased temperature	948:972	The increased temperature	948:972	The increased temperature resulted in the reduction of the hydrochar yield whereas the prolonged time enhanced the formation of solid product.
31933111	1	0	theme	acid	266:269	arg1	concentrations					277:290	lipoteichoic acid (LTA) concentrations	253:290	lipoteichoic acid (LTA) concentrations	253:290	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	3	1	dep	assessment	649:658	arg1	hybridization					704:716	Checkerboard DNA-DNA hybridization	683:716	Checkerboard DNA-DNA hybridization	683:716	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	3	1	dep	assessment	649:658	arg1	technique					669:677	culture technique	661:677	culture technique	661:677	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	14	2	with	signs	1973:1977	arg1	microorganisms					2006:2019	specific microorganisms	1997:2019	specific microorganisms	1997:2019	Higher content of LPS was positively correlated with larger periapical bone destruction, whereas signs and symptoms with specific microorganisms.
31933111	11	3	with	bacteria	1663:1670	arg1	exudate					1677:1683	exudate	1677:1683	exudate	1677:1683	In PTAP, a positive correlation was observed between both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05).
31933111	11	3	with	bacteria	1663:1670	arg1	p < .05					1715:1721	p < .05	1715:1721	p < .05	1715:1721	In PTAP, a positive correlation was observed between both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05).
31933111	11	3	with	bacteria	1663:1670	arg1	volume					1707:1712	periapical lesion volume	1689:1712	periapical lesion volume (p < .05)	1689:1722	In PTAP, a positive correlation was observed between both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05).
31933111	15	4	theme	gram-negative	2125:2137	arg1	bacteria					2139:2146	gram-negative bacteria	2125:2146	gram-negative bacteria	2125:2146	CLINICAL RELEVANCE It was verified that PAP and PTAP are polymicrobial infections with predominance of gram-negative bacteria and a more diverse bacterial population found in PTAP.
31933111	0	5	theme	lipopolysaccharides	75:93	arg1	levels					117:122	microbial composition, lipopolysaccharides and lipoteichoic acid levels	52:122	microbial composition, lipopolysaccharides and lipoteichoic acid levels	52:122	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	0	5	theme	lipopolysaccharides	75:93	arg1	symptoms					135:142	symptoms	135:142	symptoms	135:142	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	0	5	theme	lipopolysaccharides	75:93	arg1	signs					125:129	signs	125:129	signs	125:129	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	3	6	theme	LTA	748:750	arg1	levels					752:757	LTA levels	748:757	LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively)	748:837	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	14	7	with	symptoms	1983:1990	arg1	microorganisms					2006:2019	specific microorganisms	1997:2019	specific microorganisms	1997:2019	Higher content of LPS was positively correlated with larger periapical bone destruction, whereas signs and symptoms with specific microorganisms.
31933111	9	8	theme	spontaneous	1399:1409	arg1	p < .05					1417:1423	p < .05	1417:1423	p < .05	1417:1423	In PAP, gram-positive bacteria were correlated with spontaneous pain (p < .05) and exudate (p < .05).
31933111	9	8	theme	spontaneous	1399:1409	arg1	pain					1411:1414	spontaneous pain	1399:1414	spontaneous pain (p < .05)	1399:1424	In PAP, gram-positive bacteria were correlated with spontaneous pain (p < .05) and exudate (p < .05).
31933111	2	9	theme	clinical	529:536	arg1	assessment					554:563	clinical and tomographic assessment	529:563	clinical and tomographic assessment	529:563	MATERIAL AND METHODS Sixty patients with PAP (31) and PTAP (29) were submitted to clinical and tomographic assessment.
31933111	3	10	theme	LPS	740:742	arg1	determination					723:735	determination	723:735	determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively)	723:837	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	3	10	theme	LPS	740:742	arg1	assessment					649:658	microbiological assessment	633:658	microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization)	633:717	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	10	11	theme	negative	1554:1561	arg1	bacteria					1563:1570	both gram-positive and negative bacteria	1531:1570	both gram-positive and negative bacteria	1531:1570	Tenderness to percussion and pain on palpation were correlated to the presence of both gram-positive and negative bacteria.
31933111	3	12	theme	amebocyte	768:776	arg1	lysate					778:783	limulus amebocyte lysate	760:783	limulus amebocyte lysate	760:783	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	10	13	theme	gram-positive	1536:1548	arg1	bacteria					1563:1570	both gram-positive and negative bacteria	1531:1570	both gram-positive and negative bacteria	1531:1570	Tenderness to percussion and pain on palpation were correlated to the presence of both gram-positive and negative bacteria.
31933111	2	14	theme	tomographic	542:552	arg1	assessment					554:563	clinical and tomographic assessment	529:563	clinical and tomographic assessment	529:563	MATERIAL AND METHODS Sixty patients with PAP (31) and PTAP (29) were submitted to clinical and tomographic assessment.
31933111	8	15	theme	LTA	1256:1258	arg1	levels					1260:1265	LTA levels	1256:1265	LTA levels	1256:1265	LTA levels were similar in both infections and had no correlation with signs and symptoms.
31933111	13	16	theme	diverse	1838:1844	arg1	microbiota					1846:1855	a more diverse microbiota	1831:1855	a more diverse microbiota	1831:1855	However, PTAP presented a more diverse microbiota compared with PAP.
31933111	11	17	theme	periapical	1689:1698	arg1	p < .05					1715:1721	p < .05	1715:1721	p < .05	1715:1721	In PTAP, a positive correlation was observed between both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05).
31933111	11	17	theme	periapical	1689:1698	arg1	volume					1707:1712	periapical lesion volume	1689:1712	periapical lesion volume (p < .05)	1689:1722	In PTAP, a positive correlation was observed between both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05).
31933111	1	18	theme	clinical/tomographic	416:435	arg1	features					437:444	clinical/tomographic features	416:444	clinical/tomographic features	416:444	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	2	19	with	patients	474:481	arg1	PTAP					501:504	PTAP (29)	501:509	PTAP (29)	501:509	MATERIAL AND METHODS Sixty patients with PAP (31) and PTAP (29) were submitted to clinical and tomographic assessment.
31933111	2	19	with	patients	474:481	arg1	PAP					488:490	PAP (31)	488:495	PAP (31)	488:495	MATERIAL AND METHODS Sixty patients with PAP (31) and PTAP (29) were submitted to clinical and tomographic assessment.
31933111	15	20	theme	bacterial	2167:2175	arg1	population					2177:2186	a more diverse bacterial population	2152:2186	a more diverse bacterial population found in PTAP	2152:2200	CLINICAL RELEVANCE It was verified that PAP and PTAP are polymicrobial infections with predominance of gram-negative bacteria and a more diverse bacterial population found in PTAP.
31933111	16	21	theme	microbial	2234:2242	arg1	species					2244:2250	specific microbial species	2225:2250	specific microbial species	2225:2250	A wide interaction of specific microbial species resulted in different clinical features in both infections.
31933111	3	22	theme	root	599:602	arg1	canal					604:608	each root canal	594:608	each root canal	594:608	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	16	23	theme	different	2264:2272	arg1	features					2283:2290	different clinical features	2264:2290	different clinical features in both infections	2264:2309	A wide interaction of specific microbial species resulted in different clinical features in both infections.
31933111	1	24	theme	microbial	171:179	arg1	load					181:184	the microbial load	167:184	the microbial load	167:184	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	0	25	theme	acid	112:115	arg1	levels					117:122	microbial composition, lipopolysaccharides and lipoteichoic acid levels	52:122	microbial composition, lipopolysaccharides and lipoteichoic acid levels	52:122	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	0	25	theme	acid	112:115	arg1	symptoms					135:142	symptoms	135:142	symptoms	135:142	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	0	25	theme	acid	112:115	arg1	signs					125:129	signs	125:129	signs	125:129	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	1	26	theme	apical	355:360	arg1	periodontitis					362:374	post-treatment apical periodontitis	340:374	post-treatment apical periodontitis (PTAP)	340:381	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	1	26	theme	apical	355:360	arg1	PTAP					377:380	PTAP	377:380	PTAP	377:380	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	10	27	from	Tenderness	1449:1458	arg1	palpation					1486:1494	palpation	1486:1494	palpation	1486:1494	Tenderness to percussion and pain on palpation were correlated to the presence of both gram-positive and negative bacteria.
31933111	1	28	located	found	292:296	arg2	lipopolysaccharides					223:241	the lipopolysaccharides	219:241	the lipopolysaccharides (LPS)	219:247	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	1	28	located	found	292:296	arg1	periodontitis					316:328	primary apical periodontitis	301:328	primary apical periodontitis (PAP)	301:334	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	1	28	located	found	292:296	arg1	periodontitis					362:374	post-treatment apical periodontitis	340:374	post-treatment apical periodontitis (PTAP)	340:381	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	1	28	located	found	292:296	arg1	PTAP					377:380	PTAP	377:380	PTAP	377:380	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	1	28	located	found	292:296	arg1	PAP					331:333	PAP	331:333	PAP	331:333	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	1	28	located	found	292:296	arg2	LPS					244:246	LPS	244:246	LPS	244:246	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	2	29	theme	METHODS	460:466	arg1	patients					474:481	MATERIAL AND METHODS Sixty patients	447:481	MATERIAL AND METHODS Sixty patients with PAP (31) and PTAP (29)	447:509	MATERIAL AND METHODS Sixty patients with PAP (31) and PTAP (29) were submitted to clinical and tomographic assessment.
31933111	15	30	with	population	2177:2186	arg1	predominance					2109:2120	predominance	2109:2120	predominance of gram-negative bacteria	2109:2146	CLINICAL RELEVANCE It was verified that PAP and PTAP are polymicrobial infections with predominance of gram-negative bacteria and a more diverse bacterial population found in PTAP.
31933111	3	31	link	enzyme-linked	789:801	arg1	assays					817:822	enzyme-linked immunosorbent assays	789:822	enzyme-linked immunosorbent assays	789:822	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	0	32	theme	Primary	0:6	arg1	periodontitis					37:49	Primary versus post-treatment apical periodontitis	0:49	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.	0:143	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	16	33	from	features	2283:2290	arg1	infections					2300:2309	both infections	2295:2309	both infections	2295:2309	A wide interaction of specific microbial species resulted in different clinical features in both infections.
31933111	11	34	theme	gram-positive	1631:1643	arg1	bacteria					1663:1670	both gram-positive and gram-negative bacteria	1626:1670	both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05)	1626:1722	In PTAP, a positive correlation was observed between both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05).
31933111	2	35	theme	MATERIAL	447:454	arg1	patients					474:481	MATERIAL AND METHODS Sixty patients	447:481	MATERIAL AND METHODS Sixty patients with PAP (31) and PTAP (29)	447:509	MATERIAL AND METHODS Sixty patients with PAP (31) and PTAP (29) were submitted to clinical and tomographic assessment.
31933111	16	36	theme	wide	2205:2208	arg1	interaction					2210:2220	A wide interaction	2203:2220	A wide interaction of specific microbial species	2203:2250	A wide interaction of specific microbial species resulted in different clinical features in both infections.
31933111	0	37	theme	post-treatment	15:28	arg1	periodontitis					37:49	Primary versus post-treatment apical periodontitis	0:49	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.	0:143	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	15	38	dep	RELEVANCE	2031:2039	arg1	It					2041:2042	It	2041:2042	It	2041:2042	CLINICAL RELEVANCE It was verified that PAP and PTAP are polymicrobial infections with predominance of gram-negative bacteria and a more diverse bacterial population found in PTAP.
31933111	14	39	theme	specific	1997:2004	arg1	microorganisms					2006:2019	specific microorganisms	1997:2019	specific microorganisms	1997:2019	Higher content of LPS was positively correlated with larger periapical bone destruction, whereas signs and symptoms with specific microorganisms.
31933111	3	40	theme	microbiological	633:647	arg1	assessment					649:658	microbiological assessment	633:658	microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization)	633:717	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	11	41	located	observed	1609:1616	arg1	PTAP					1576:1579	PTAP	1576:1579	PTAP	1576:1579	In PTAP, a positive correlation was observed between both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05).
31933111	11	41	located	observed	1609:1616	arg2	correlation					1593:1603	a positive correlation	1582:1603	a positive correlation	1582:1603	In PTAP, a positive correlation was observed between both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05).
31933111	1	42	theme	primary	301:307	arg1	PAP					331:333	PAP	331:333	PAP	331:333	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	1	42	theme	primary	301:307	arg1	periodontitis					316:328	primary apical periodontitis	301:328	primary apical periodontitis (PAP)	301:334	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	14	43	theme	LPS	1894:1896	arg1	content					1883:1889	Higher content	1876:1889	Higher content of LPS	1876:1896	Higher content of LPS was positively correlated with larger periapical bone destruction, whereas signs and symptoms with specific microorganisms.
31933111	0	44	theme	microbial	52:60	arg1	composition					62:72	microbial composition	52:72	microbial composition	52:72	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	12	45	theme	load	1774:1777	arg1	contents					1752:1759	higher contents	1745:1759	higher contents of microbial load and LPS	1745:1785	CONCLUSIONS PAP had higher contents of microbial load and LPS compared with PTAP.
31933111	0	46	dep	periodontitis	37:49	arg1	levels					117:122	microbial composition, lipopolysaccharides and lipoteichoic acid levels	52:122	microbial composition, lipopolysaccharides and lipoteichoic acid levels	52:122	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	0	46	dep	periodontitis	37:49	arg1	symptoms					135:142	symptoms	135:142	symptoms	135:142	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	0	46	dep	periodontitis	37:49	arg1	signs					125:129	signs	125:129	signs	125:129	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	12	47	theme	microbial	1764:1772	arg1	load					1774:1777	microbial load	1764:1777	microbial load	1764:1777	CONCLUSIONS PAP had higher contents of microbial load and LPS compared with PTAP.
31933111	12	48	theme	LPS	1783:1785	arg1	contents					1752:1759	higher contents	1745:1759	higher contents of microbial load and LPS	1745:1785	CONCLUSIONS PAP had higher contents of microbial load and LPS compared with PTAP.
31933111	6	49	theme	root	1104:1107	arg1	canal					1109:1113	root canal	1104:1113	root canal found in PAP and PTAP	1104:1135	The median number of species per root canal found in PAP and PTAP was 9 and 22, respectively (p < 0.05).
31933111	11	50	theme	gram-negative	1649:1661	arg1	bacteria					1663:1670	both gram-positive and gram-negative bacteria	1626:1670	both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05)	1626:1722	In PTAP, a positive correlation was observed between both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05).
31933111	5	51	located	found	1046:1050	arg2	LPS					1037:1039	LPS	1037:1039	LPS	1037:1039	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	5	51	located	found	1046:1050	arg2	number					1003:1008	A higher number	994:1008	A higher number of cultivable bacteria	994:1031	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	5	51	located	found	1046:1050	arg2	RESULTS					986:992	RESULTS A higher number of cultivable bacteria and LPS	986:1039	RESULTS A higher number of cultivable bacteria and LPS	986:1039	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	5	51	located	found	1046:1050	arg1	p < 0.05					1060:1067	p < 0.05	1060:1067	p < 0.05	1060:1067	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	5	51	located	found	1046:1050	arg1	PAP					1055:1057	PAP	1055:1057	PAP (p < 0.05)	1055:1068	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	5	52	theme	bacteria	1024:1031	arg1	LPS					1037:1039	LPS	1037:1039	LPS	1037:1039	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	5	52	theme	bacteria	1024:1031	arg1	number					1003:1008	A higher number	994:1008	A higher number of cultivable bacteria	994:1031	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	5	52	theme	bacteria	1024:1031	arg1	RESULTS					986:992	RESULTS A higher number of cultivable bacteria and LPS	986:1039	RESULTS A higher number of cultivable bacteria and LPS	986:1039	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	7	53	theme	larger	1213:1218	arg1	p < .05					1246:1252	p < .05	1246:1252	p < .05	1246:1252	LPS was positively correlated with a larger periapical lesion volume (p < .05).
31933111	7	53	theme	larger	1213:1218	arg1	volume					1238:1243	a larger periapical lesion volume	1211:1243	a larger periapical lesion volume (p < .05)	1211:1253	LPS was positively correlated with a larger periapical lesion volume (p < .05).
31933111	1	54	theme	lipoteichoic	253:264	arg1	acid					266:269	lipoteichoic acid	253:269	lipoteichoic acid (LTA) concentrations	253:290	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	1	54	theme	lipoteichoic	253:264	arg1	LTA					272:274	LTA	272:274	LTA	272:274	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	4	55	theme	clinical/tomographic	866:885	arg1	findings					887:894	clinical/tomographic findings	866:894	clinical/tomographic findings	866:894	Data were correlated with clinical/tomographic findings and statistically analyzed using the Mann-Whitney and Pearson correlation tests (α = 5%).
31933111	5	56	theme	higher	996:1001	arg1	RESULTS					986:992	RESULTS A higher number of cultivable bacteria and LPS	986:1039	RESULTS A higher number of cultivable bacteria and LPS	986:1039	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	5	56	theme	higher	996:1001	arg1	number					1003:1008	A higher number	994:1008	A higher number of cultivable bacteria	994:1031	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	3	57	theme	Checkerboard	683:694	arg1	hybridization					704:716	Checkerboard DNA-DNA hybridization	683:716	Checkerboard DNA-DNA hybridization	683:716	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	9	58	theme	gram-positive	1355:1367	arg1	bacteria					1369:1376	gram-positive bacteria	1355:1376	gram-positive bacteria	1355:1376	In PAP, gram-positive bacteria were correlated with spontaneous pain (p < .05) and exudate (p < .05).
31933111	15	59	located	found	2188:2192	arg2	population					2177:2186	a more diverse bacterial population	2152:2186	a more diverse bacterial population found in PTAP	2152:2200	CLINICAL RELEVANCE It was verified that PAP and PTAP are polymicrobial infections with predominance of gram-negative bacteria and a more diverse bacterial population found in PTAP.
31933111	15	59	located	found	2188:2192	arg1	PTAP					2197:2200	PTAP	2197:2200	PTAP	2197:2200	CLINICAL RELEVANCE It was verified that PAP and PTAP are polymicrobial infections with predominance of gram-negative bacteria and a more diverse bacterial population found in PTAP.
31933111	11	60	theme	positive	1584:1591	arg1	correlation					1593:1603	a positive correlation	1582:1603	a positive correlation	1582:1603	In PTAP, a positive correlation was observed between both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05).
31933111	3	61	theme	levels	752:757	arg1	determination					723:735	determination	723:735	determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively)	723:837	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	3	61	theme	levels	752:757	arg1	assessment					649:658	microbiological assessment	633:658	microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization)	633:717	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	15	62	theme	polymicrobial	2079:2091	arg1	PTAP					2070:2073	PTAP	2070:2073	PTAP	2070:2073	CLINICAL RELEVANCE It was verified that PAP and PTAP are polymicrobial infections with predominance of gram-negative bacteria and a more diverse bacterial population found in PTAP.
31933111	15	62	theme	polymicrobial	2079:2091	arg1	infections					2093:2102	polymicrobial infections	2079:2102	polymicrobial infections with predominance of gram-negative bacteria	2079:2146	CLINICAL RELEVANCE It was verified that PAP and PTAP are polymicrobial infections with predominance of gram-negative bacteria and a more diverse bacterial population found in PTAP.
31933111	15	62	theme	polymicrobial	2079:2091	arg1	PAP					2062:2064	PAP	2062:2064	PAP	2062:2064	CLINICAL RELEVANCE It was verified that PAP and PTAP are polymicrobial infections with predominance of gram-negative bacteria and a more diverse bacterial population found in PTAP.
31933111	6	63	dep	9	1141:1141	arg1	p < 0.05					1165:1172	p < 0.05	1165:1172	p < 0.05	1165:1172	The median number of species per root canal found in PAP and PTAP was 9 and 22, respectively (p < 0.05).
31933111	10	64	theme	bacteria	1563:1570	arg1	presence					1519:1526	the presence	1515:1526	the presence of both gram-positive and negative bacteria	1515:1570	Tenderness to percussion and pain on palpation were correlated to the presence of both gram-positive and negative bacteria.
31933111	3	65	dep	enzyme-linked	789:801	arg1	immunosorbent					803:815	immunosorbent	803:815	immunosorbent	803:815	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	4	66	theme	correlation	958:968	arg1	tests					970:974	Pearson correlation tests	950:974	Pearson correlation tests	950:974	Data were correlated with clinical/tomographic findings and statistically analyzed using the Mann-Whitney and Pearson correlation tests (α = 5%).
31933111	3	67	dep	levels	752:757	arg1	assays					817:822	enzyme-linked immunosorbent assays	789:822	enzyme-linked immunosorbent assays	789:822	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	3	67	dep	levels	752:757	arg1	lysate					778:783	limulus amebocyte lysate	760:783	limulus amebocyte lysate	760:783	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	4	68	theme	Pearson	950:956	arg1	tests					970:974	Pearson correlation tests	950:974	Pearson correlation tests	950:974	Data were correlated with clinical/tomographic findings and statistically analyzed using the Mann-Whitney and Pearson correlation tests (α = 5%).
31933111	6	69	located	found	1115:1119	arg1	PTAP					1132:1135	PTAP	1132:1135	PTAP	1132:1135	The median number of species per root canal found in PAP and PTAP was 9 and 22, respectively (p < 0.05).
31933111	6	69	located	found	1115:1119	arg1	PAP					1124:1126	PAP	1124:1126	PAP	1124:1126	The median number of species per root canal found in PAP and PTAP was 9 and 22, respectively (p < 0.05).
31933111	6	69	located	found	1115:1119	arg2	canal					1109:1113	root canal	1104:1113	root canal found in PAP and PTAP	1104:1135	The median number of species per root canal found in PAP and PTAP was 9 and 22, respectively (p < 0.05).
31933111	16	70	theme	species	2244:2250	arg1	interaction					2210:2220	A wide interaction	2203:2220	A wide interaction of specific microbial species	2203:2250	A wide interaction of specific microbial species resulted in different clinical features in both infections.
31933111	3	71	theme	limulus	760:766	arg1	lysate					778:783	limulus amebocyte lysate	760:783	limulus amebocyte lysate	760:783	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	15	72	theme	diverse	2159:2165	arg1	population					2177:2186	a more diverse bacterial population	2152:2186	a more diverse bacterial population found in PTAP	2152:2200	CLINICAL RELEVANCE It was verified that PAP and PTAP are polymicrobial infections with predominance of gram-negative bacteria and a more diverse bacterial population found in PTAP.
31933111	5	73	dep	RESULTS	986:992	arg1	LPS					1037:1039	LPS	1037:1039	LPS	1037:1039	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	5	73	dep	RESULTS	986:992	arg1	number					1003:1008	A higher number	994:1008	A higher number of cultivable bacteria	994:1031	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	5	73	dep	RESULTS	986:992	arg1	RESULTS					986:992	RESULTS A higher number of cultivable bacteria and LPS	986:1039	RESULTS A higher number of cultivable bacteria and LPS	986:1039	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	11	74	theme	lesion	1700:1705	arg1	p < .05					1715:1721	p < .05	1715:1721	p < .05	1715:1721	In PTAP, a positive correlation was observed between both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05).
31933111	11	74	theme	lesion	1700:1705	arg1	volume					1707:1712	periapical lesion volume	1689:1712	periapical lesion volume (p < .05)	1689:1722	In PTAP, a positive correlation was observed between both gram-positive and gram-negative bacteria with exudate and periapical lesion volume (p < .05).
31933111	4	75	dep	Mann-Whitney	933:944	arg1	the					929:931	the	929:931	the	929:931	Data were correlated with clinical/tomographic findings and statistically analyzed using the Mann-Whitney and Pearson correlation tests (α = 5%).
31933111	16	76	theme	clinical	2274:2281	arg1	features					2283:2290	different clinical features	2264:2290	different clinical features in both infections	2264:2309	A wide interaction of specific microbial species resulted in different clinical features in both infections.
31933111	3	77	theme	enzyme-linked	789:801	arg1	assays					817:822	enzyme-linked immunosorbent assays	789:822	enzyme-linked immunosorbent assays	789:822	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	0	78	theme	lipoteichoic	99:110	arg1	acid					112:115	lipoteichoic acid	99:115	lipoteichoic acid	99:115	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	15	79	theme	bacteria	2139:2146	arg1	predominance					2109:2120	predominance	2109:2120	predominance of gram-negative bacteria	2109:2146	CLINICAL RELEVANCE It was verified that PAP and PTAP are polymicrobial infections with predominance of gram-negative bacteria and a more diverse bacterial population found in PTAP.
31933111	1	80	theme	post-treatment	340:353	arg1	periodontitis					362:374	post-treatment apical periodontitis	340:374	post-treatment apical periodontitis (PTAP)	340:381	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	1	80	theme	post-treatment	340:353	arg1	PTAP					377:380	PTAP	377:380	PTAP	377:380	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	8	81	contain	had	1303:1305	arg2	correlation					1310:1320	no correlation	1307:1320	no correlation	1307:1320	LTA levels were similar in both infections and had no correlation with signs and symptoms.
31933111	8	81	contain	had	1303:1305	arg1	levels					1260:1265	LTA levels	1256:1265	LTA levels	1256:1265	LTA levels were similar in both infections and had no correlation with signs and symptoms.
31933111	7	82	theme	lesion	1231:1236	arg1	p < .05					1246:1252	p < .05	1246:1252	p < .05	1246:1252	LPS was positively correlated with a larger periapical lesion volume (p < .05).
31933111	7	82	theme	lesion	1231:1236	arg1	volume					1238:1243	a larger periapical lesion volume	1211:1243	a larger periapical lesion volume (p < .05)	1211:1253	LPS was positively correlated with a larger periapical lesion volume (p < .05).
31933111	14	83	theme	bone	1947:1950	arg1	destruction					1952:1962	larger periapical bone destruction	1929:1962	larger periapical bone destruction	1929:1962	Higher content of LPS was positively correlated with larger periapical bone destruction, whereas signs and symptoms with specific microorganisms.
31933111	6	84	theme	median	1075:1080	arg1	number					1082:1087	The median number	1071:1087	The median number of species per root canal found in PAP and PTAP	1071:1135	The median number of species per root canal found in PAP and PTAP was 9 and 22, respectively (p < 0.05).
31933111	6	84	theme	median	1075:1080	arg1	9					1141:1141	9	1141:1141	9	1141:1141	The median number of species per root canal found in PAP and PTAP was 9 and 22, respectively (p < 0.05).
31933111	8	85	from	similar	1272:1278	arg1	infections					1288:1297	both infections	1283:1297	both infections	1283:1297	LTA levels were similar in both infections and had no correlation with signs and symptoms.
31933111	14	86	theme	larger	1929:1934	arg1	destruction					1952:1962	larger periapical bone destruction	1929:1962	larger periapical bone destruction	1929:1962	Higher content of LPS was positively correlated with larger periapical bone destruction, whereas signs and symptoms with specific microorganisms.
31933111	0	87	theme	apical	30:35	arg1	periodontitis					37:49	Primary versus post-treatment apical periodontitis	0:49	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.	0:143	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	15	88	theme	CLINICAL	2022:2029	arg1	RELEVANCE					2031:2039	CLINICAL RELEVANCE	2022:2039	CLINICAL RELEVANCE It	2022:2042	CLINICAL RELEVANCE It was verified that PAP and PTAP are polymicrobial infections with predominance of gram-negative bacteria and a more diverse bacterial population found in PTAP.
31933111	16	89	theme	specific	2225:2232	arg1	species					2244:2250	specific microbial species	2225:2250	specific microbial species	2225:2250	A wide interaction of specific microbial species resulted in different clinical features in both infections.
31933111	15	90	with	infections	2093:2102	arg1	predominance					2109:2120	predominance	2109:2120	predominance of gram-negative bacteria	2109:2146	CLINICAL RELEVANCE It was verified that PAP and PTAP are polymicrobial infections with predominance of gram-negative bacteria and a more diverse bacterial population found in PTAP.
31933111	3	91	theme	paper	616:620	arg1	points					622:627	paper points	616:627	paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively)	616:837	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	0	92	theme	composition	62:72	arg1	levels					117:122	microbial composition, lipopolysaccharides and lipoteichoic acid levels	52:122	microbial composition, lipopolysaccharides and lipoteichoic acid levels	52:122	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	0	92	theme	composition	62:72	arg1	symptoms					135:142	symptoms	135:142	symptoms	135:142	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	0	92	theme	composition	62:72	arg1	signs					125:129	signs	125:129	signs	125:129	Primary versus post-treatment apical periodontitis: microbial composition, lipopolysaccharides and lipoteichoic acid levels, signs and symptoms.
31933111	1	93	theme	apical	309:314	arg1	PAP					331:333	PAP	331:333	PAP	331:333	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	1	93	theme	apical	309:314	arg1	periodontitis					316:328	primary apical periodontitis	301:328	primary apical periodontitis (PAP)	301:334	OBJECTIVES To compare the microbial load and composition and to determine the lipopolysaccharides (LPS) and lipoteichoic acid (LTA) concentrations found in primary apical periodontitis (PAP) and post-treatment apical periodontitis (PTAP), correlating these findings with clinical/tomographic features.
31933111	12	94	theme	higher	1745:1750	arg1	contents					1752:1759	higher contents	1745:1759	higher contents of microbial load and LPS	1745:1785	CONCLUSIONS PAP had higher contents of microbial load and LPS compared with PTAP.
31933111	2	95	theme	Sixty	468:472	arg1	patients					474:481	MATERIAL AND METHODS Sixty patients	447:481	MATERIAL AND METHODS Sixty patients with PAP (31) and PTAP (29)	447:509	MATERIAL AND METHODS Sixty patients with PAP (31) and PTAP (29) were submitted to clinical and tomographic assessment.
31933111	3	96	theme	culture	661:667	arg1	technique					669:677	culture technique	661:677	culture technique	661:677	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
31933111	14	97	theme	Higher	1876:1881	arg1	content					1883:1889	Higher content	1876:1889	Higher content of LPS	1876:1896	Higher content of LPS was positively correlated with larger periapical bone destruction, whereas signs and symptoms with specific microorganisms.
31933111	7	98	theme	periapical	1220:1229	arg1	p < .05					1246:1252	p < .05	1246:1252	p < .05	1246:1252	LPS was positively correlated with a larger periapical lesion volume (p < .05).
31933111	7	98	theme	periapical	1220:1229	arg1	volume					1238:1243	a larger periapical lesion volume	1211:1243	a larger periapical lesion volume (p < .05)	1211:1253	LPS was positively correlated with a larger periapical lesion volume (p < .05).
31933111	14	99	theme	periapical	1936:1945	arg1	destruction					1952:1962	larger periapical bone destruction	1929:1962	larger periapical bone destruction	1929:1962	Higher content of LPS was positively correlated with larger periapical bone destruction, whereas signs and symptoms with specific microorganisms.
31933111	6	100	theme	species	1092:1098	arg1	number					1082:1087	The median number	1071:1087	The median number of species per root canal found in PAP and PTAP	1071:1135	The median number of species per root canal found in PAP and PTAP was 9 and 22, respectively (p < 0.05).
31933111	6	100	theme	species	1092:1098	arg1	9					1141:1141	9	1141:1141	9	1141:1141	The median number of species per root canal found in PAP and PTAP was 9 and 22, respectively (p < 0.05).
31933111	8	101	from	infections	1288:1297	arg1	similar					1272:1278	similar	1272:1278	similar	1272:1278	LTA levels were similar in both infections and had no correlation with signs and symptoms.
31933111	5	102	theme	cultivable	1013:1022	arg1	bacteria					1024:1031	cultivable bacteria	1013:1031	cultivable bacteria	1013:1031	RESULTS A higher number of cultivable bacteria and LPS were found in PAP (p < 0.05).
31933111	3	103	theme	DNA-DNA	696:702	arg1	hybridization					704:716	Checkerboard DNA-DNA hybridization	683:716	Checkerboard DNA-DNA hybridization	683:716	Samples were collected from each root canal using paper points for microbiological assessment (culture technique and Checkerboard DNA-DNA hybridization) and determination of LPS and LTA levels (limulus amebocyte lysate and enzyme-linked immunosorbent assays, respectively).
33784250	0	0	theme	tissue	94:99	arg1	engineering					101:111	cartilage tissue engineering	84:111	cartilage tissue engineering	84:111	Fabrication and characterization of an injectable reinforced composite scaffold for cartilage tissue engineering: an in vitro study.
33784250	11	1	theme	composite	1371:1379	arg1	hydrogel					1381:1388	this composite hydrogel	1366:1388	this composite hydrogel	1366:1388	Biocompatibility and preliminary differentiation investigations revealed that this composite hydrogel might have potential benefits for cartilage tissue engineering.
33784250	6	2	theme	human	770:774	arg1	donors					776:781	human donors	770:781	human donors	770:781	Articular cartilage from human donors was decellularized by a combination of physical, chemical, and enzymatic methods.
33784250	7	3	theme	DNA	954:956	arg1	content					958:964	DNA content	954:964	DNA content	954:964	The decellularization efficiency was assessed by histological analysis and assessment of DNA content.
33784250	0	4	theme	cartilage	84:92	arg1	engineering					101:111	cartilage tissue engineering	84:111	cartilage tissue engineering	84:111	Fabrication and characterization of an injectable reinforced composite scaffold for cartilage tissue engineering: an in vitro study.
33784250	4	5	from	particles	547:555	arg1	hydrogel					467:474	an injectable composite hydrogel	443:474	an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles	443:555	In this study, we created an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles.
33784250	8	6	theme	gelation	1038:1045	arg1	time					1047:1050	gelation time	1038:1050	gelation time	1038:1050	We characterized the composite constructs in terms of storage modulus, gelation time, biocompatibility, and differentiation potential.
33784250	1	7	theme	current	158:164	arg1	medications					166:176	current medications	158:176	current medications of articular cartilage injuries	158:208	There are limitations in current medications of articular cartilage injuries.
33784250	9	8	theme	mechanical	1126:1135	arg1	behavior					1137:1144	mechanical behavior	1126:1144	mechanical behavior	1126:1144	The results showed that mechanical behavior increased with an increase in microsphere content.
33784250	8	9	theme	biocompatibility	1053:1068	arg1	terms					1012:1016	terms	1012:1016	terms of storage modulus, gelation time, biocompatibility, and differentiation potential	1012:1099	We characterized the composite constructs in terms of storage modulus, gelation time, biocompatibility, and differentiation potential.
33784250	5	10	theme	structural	701:710	arg1	blocks					721:726	the structural building blocks	697:726	the structural building blocks of the scaffold	697:742	In order to enhance its mechanical properties, we reinforced this hydrogel with microporous microspheres composed of the same materials as the structural building blocks of the scaffold.
33784250	5	11	theme	microporous	638:648	arg1	microspheres					650:661	microporous microspheres	638:661	microporous microspheres composed of the same materials as the structural building blocks of the scaffold	638:742	In order to enhance its mechanical properties, we reinforced this hydrogel with microporous microspheres composed of the same materials as the structural building blocks of the scaffold.
33784250	0	12	dep	in	117:118	arg1	vitro					120:124	vitro	120:124	vitro	120:124	Fabrication and characterization of an injectable reinforced composite scaffold for cartilage tissue engineering: an in vitro study.
33784250	8	13	theme	storage	1021:1027	arg1	modulus					1029:1035	storage modulus	1021:1035	storage modulus	1021:1035	We characterized the composite constructs in terms of storage modulus, gelation time, biocompatibility, and differentiation potential.
33784250	4	14	theme	extracellular	520:532	arg1	matrix					534:539	acellular cartilage extracellular matrix	500:539	chitosan and human acellular cartilage extracellular matrix (ECM) particles	481:555	In this study, we created an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles.
33784250	4	14	theme	extracellular	520:532	arg1	ECM					542:544	ECM	542:544	ECM	542:544	In this study, we created an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles.
33784250	5	15	theme	building	712:719	arg1	blocks					721:726	the structural building blocks	697:726	the structural building blocks of the scaffold	697:742	In order to enhance its mechanical properties, we reinforced this hydrogel with microporous microspheres composed of the same materials as the structural building blocks of the scaffold.
33784250	6	16	theme	enzymatic	846:854	arg1	methods					856:862	physical, chemical, and enzymatic methods	822:862	physical, chemical, and enzymatic methods	822:862	Articular cartilage from human donors was decellularized by a combination of physical, chemical, and enzymatic methods.
33784250	7	17	theme	histological	914:925	arg1	analysis					927:934	histological analysis	914:934	histological analysis	914:934	The decellularization efficiency was assessed by histological analysis and assessment of DNA content.
33784250	2	18	contain	have	279:282	arg1	they					274:277	they	274:277	they	274:277	Although injectable bioactive hydrogels are promising options, they have decreased biomechanical performance.
33784250	2	18	contain	have	279:282	arg2	performance					308:318	decreased biomechanical performance	284:318	decreased biomechanical performance	284:318	Although injectable bioactive hydrogels are promising options, they have decreased biomechanical performance.
33784250	0	19	theme	in	117:118	arg1	study					126:130	an in vitro study	114:130	Fabrication and characterization of an injectable reinforced composite scaffold for cartilage tissue engineering: an in vitro study.	0:131	Fabrication and characterization of an injectable reinforced composite scaffold for cartilage tissue engineering: an in vitro study.
33784250	4	20	theme	cartilage	510:518	arg1	matrix					534:539	acellular cartilage extracellular matrix	500:539	chitosan and human acellular cartilage extracellular matrix (ECM) particles	481:555	In this study, we created an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles.
33784250	4	20	theme	cartilage	510:518	arg1	ECM					542:544	ECM	542:544	ECM	542:544	In this study, we created an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles.
33784250	11	21	theme	potential	1401:1409	arg1	benefits					1411:1418	potential benefits	1401:1418	potential benefits	1401:1418	Biocompatibility and preliminary differentiation investigations revealed that this composite hydrogel might have potential benefits for cartilage tissue engineering.
33784250	1	22	from	limitations	143:153	arg1	medications					166:176	current medications	158:176	current medications of articular cartilage injuries	158:208	There are limitations in current medications of articular cartilage injuries.
33784250	2	23	theme	biomechanical	294:306	arg1	performance					308:318	decreased biomechanical performance	284:318	decreased biomechanical performance	284:318	Although injectable bioactive hydrogels are promising options, they have decreased biomechanical performance.
33784250	11	24	contain	have	1396:1399	arg2	benefits					1411:1418	potential benefits	1401:1418	potential benefits	1401:1418	Biocompatibility and preliminary differentiation investigations revealed that this composite hydrogel might have potential benefits for cartilage tissue engineering.
33784250	11	24	contain	have	1396:1399	arg1	hydrogel					1381:1388	this composite hydrogel	1366:1388	this composite hydrogel	1366:1388	Biocompatibility and preliminary differentiation investigations revealed that this composite hydrogel might have potential benefits for cartilage tissue engineering.
33784250	2	25	theme	decreased	284:292	arg1	performance					308:318	decreased biomechanical performance	284:318	decreased biomechanical performance	284:318	Although injectable bioactive hydrogels are promising options, they have decreased biomechanical performance.
33784250	6	26	theme	Articular	745:753	arg1	cartilage					755:763	Articular cartilage	745:763	Articular cartilage from human donors	745:781	Articular cartilage from human donors was decellularized by a combination of physical, chemical, and enzymatic methods.
33784250	11	27	theme	tissue	1434:1439	arg1	engineering					1441:1451	cartilage tissue engineering	1424:1451	cartilage tissue engineering	1424:1451	Biocompatibility and preliminary differentiation investigations revealed that this composite hydrogel might have potential benefits for cartilage tissue engineering.
33784250	4	28	theme	matrix	534:539	arg1	particles					547:555	chitosan and human acellular cartilage extracellular matrix (ECM) particles	481:555	chitosan and human acellular cartilage extracellular matrix (ECM) particles	481:555	In this study, we created an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles.
33784250	5	29	theme	same	679:682	arg1	materials					684:692	the same materials	675:692	the same materials as the structural building blocks of the scaffold	675:742	In order to enhance its mechanical properties, we reinforced this hydrogel with microporous microspheres composed of the same materials as the structural building blocks of the scaffold.
33784250	6	30	theme	chemical	832:839	arg1	methods					856:862	physical, chemical, and enzymatic methods	822:862	physical, chemical, and enzymatic methods	822:862	Articular cartilage from human donors was decellularized by a combination of physical, chemical, and enzymatic methods.
33784250	1	31	theme	articular	181:189	arg1	injuries					201:208	articular cartilage injuries	181:208	articular cartilage injuries	181:208	There are limitations in current medications of articular cartilage injuries.
33784250	8	32	theme	differentiation	1075:1089	arg1	potential					1091:1099	differentiation potential	1075:1099	differentiation potential	1075:1099	We characterized the composite constructs in terms of storage modulus, gelation time, biocompatibility, and differentiation potential.
33784250	4	33	theme	composite	457:465	arg1	hydrogel					467:474	an injectable composite hydrogel	443:474	an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles	443:555	In this study, we created an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles.
33784250	1	34	theme	cartilage	191:199	arg1	injuries					201:208	articular cartilage injuries	181:208	articular cartilage injuries	181:208	There are limitations in current medications of articular cartilage injuries.
33784250	10	35	contain	had	1239:1241	arg2	modulus					1263:1269	an enhanced storage modulus	1243:1269	an enhanced storage modulus of up to 90 kPa	1243:1285	The sample that contained 10% microsphere had an enhanced storage modulus of up to 90 kPa.
33784250	10	35	contain	had	1239:1241	arg1	sample					1201:1206	The sample	1197:1206	The sample that contained 10% microsphere	1197:1237	The sample that contained 10% microsphere had an enhanced storage modulus of up to 90 kPa.
33784250	5	36	with	hydrogel	624:631	arg1	microspheres					650:661	microporous microspheres	638:661	microporous microspheres composed of the same materials as the structural building blocks of the scaffold	638:742	In order to enhance its mechanical properties, we reinforced this hydrogel with microporous microspheres composed of the same materials as the structural building blocks of the scaffold.
33784250	11	37	theme	Biocompatibility	1288:1303	arg1	investigations					1337:1350	Biocompatibility and preliminary differentiation investigations	1288:1350	Biocompatibility and preliminary differentiation investigations	1288:1350	Biocompatibility and preliminary differentiation investigations revealed that this composite hydrogel might have potential benefits for cartilage tissue engineering.
33784250	6	38	theme	physical	822:829	arg1	methods					856:862	physical, chemical, and enzymatic methods	822:862	physical, chemical, and enzymatic methods	822:862	Articular cartilage from human donors was decellularized by a combination of physical, chemical, and enzymatic methods.
33784250	9	39	theme	microsphere	1176:1186	arg1	content					1188:1194	microsphere content	1176:1194	microsphere content	1176:1194	The results showed that mechanical behavior increased with an increase in microsphere content.
33784250	1	40	theme	injuries	201:208	arg1	medications					166:176	current medications	158:176	current medications of articular cartilage injuries	158:208	There are limitations in current medications of articular cartilage injuries.
33784250	11	41	theme	cartilage	1424:1432	arg1	engineering					1441:1451	cartilage tissue engineering	1424:1451	cartilage tissue engineering	1424:1451	Biocompatibility and preliminary differentiation investigations revealed that this composite hydrogel might have potential benefits for cartilage tissue engineering.
33784250	0	42	theme	injectable	39:48	arg1	scaffold					71:78	an injectable reinforced composite scaffold	36:78	an injectable reinforced composite scaffold for cartilage tissue engineering	36:111	Fabrication and characterization of an injectable reinforced composite scaffold for cartilage tissue engineering: an in vitro study.
33784250	4	43	theme	chitosan	481:488	arg1	particles					547:555	chitosan and human acellular cartilage extracellular matrix (ECM) particles	481:555	chitosan and human acellular cartilage extracellular matrix (ECM) particles	481:555	In this study, we created an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles.
33784250	2	44	theme	promising	255:263	arg1	hydrogels					241:249	injectable bioactive hydrogels	220:249	injectable bioactive hydrogels	220:249	Although injectable bioactive hydrogels are promising options, they have decreased biomechanical performance.
33784250	2	44	theme	promising	255:263	arg1	options					265:271	promising options	255:271	promising options	255:271	Although injectable bioactive hydrogels are promising options, they have decreased biomechanical performance.
33784250	7	45	theme	decellularization	869:885	arg1	efficiency					887:896	The decellularization efficiency	865:896	The decellularization efficiency	865:896	The decellularization efficiency was assessed by histological analysis and assessment of DNA content.
33784250	10	46	contain	contained	1213:1221	arg2	microsphere					1227:1237	10% microsphere	1223:1237	10% microsphere	1223:1237	The sample that contained 10% microsphere had an enhanced storage modulus of up to 90 kPa.
33784250	10	46	contain	contained	1213:1221	arg1	sample					1201:1206	The sample	1197:1206	The sample that contained 10% microsphere	1197:1237	The sample that contained 10% microsphere had an enhanced storage modulus of up to 90 kPa.
33784250	4	47	theme	acellular	500:508	arg1	matrix					534:539	acellular cartilage extracellular matrix	500:539	chitosan and human acellular cartilage extracellular matrix (ECM) particles	481:555	In this study, we created an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles.
33784250	4	47	theme	acellular	500:508	arg1	ECM					542:544	ECM	542:544	ECM	542:544	In this study, we created an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles.
33784250	10	48	theme	enhanced	1246:1253	arg1	modulus					1263:1269	an enhanced storage modulus	1243:1269	an enhanced storage modulus of up to 90 kPa	1243:1285	The sample that contained 10% microsphere had an enhanced storage modulus of up to 90 kPa.
33784250	8	49	theme	composite	988:996	arg1	constructs					998:1007	the composite constructs	984:1007	the composite constructs	984:1007	We characterized the composite constructs in terms of storage modulus, gelation time, biocompatibility, and differentiation potential.
33784250	0	50	theme	composite	61:69	arg1	scaffold					71:78	an injectable reinforced composite scaffold	36:78	an injectable reinforced composite scaffold for cartilage tissue engineering	36:111	Fabrication and characterization of an injectable reinforced composite scaffold for cartilage tissue engineering: an in vitro study.
33784250	4	51	theme	human	494:498	arg1	particles					547:555	chitosan and human acellular cartilage extracellular matrix (ECM) particles	481:555	chitosan and human acellular cartilage extracellular matrix (ECM) particles	481:555	In this study, we created an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles.
33784250	5	52	theme	mechanical	582:591	arg1	properties					593:602	its mechanical properties	578:602	its mechanical properties	578:602	In order to enhance its mechanical properties, we reinforced this hydrogel with microporous microspheres composed of the same materials as the structural building blocks of the scaffold.
33784250	0	53	theme	reinforced	50:59	arg1	scaffold					71:78	an injectable reinforced composite scaffold	36:78	an injectable reinforced composite scaffold for cartilage tissue engineering	36:111	Fabrication and characterization of an injectable reinforced composite scaffold for cartilage tissue engineering: an in vitro study.
33784250	10	54	theme	%	1225:1225	arg1	microsphere					1227:1237	10% microsphere	1223:1237	10% microsphere	1223:1237	The sample that contained 10% microsphere had an enhanced storage modulus of up to 90 kPa.
33784250	3	55	theme	many	349:352	arg1	factors					354:360	many factors	349:360	many factors	349:360	Researchers should consider many factors when providing solutions to overcome these challenges.
33784250	2	56	theme	injectable	220:229	arg1	hydrogels					241:249	injectable bioactive hydrogels	220:249	injectable bioactive hydrogels	220:249	Although injectable bioactive hydrogels are promising options, they have decreased biomechanical performance.
33784250	2	56	theme	injectable	220:229	arg1	options					265:271	promising options	255:271	promising options	255:271	Although injectable bioactive hydrogels are promising options, they have decreased biomechanical performance.
33784250	2	57	theme	bioactive	231:239	arg1	hydrogels					241:249	injectable bioactive hydrogels	220:249	injectable bioactive hydrogels	220:249	Although injectable bioactive hydrogels are promising options, they have decreased biomechanical performance.
33784250	2	57	theme	bioactive	231:239	arg1	options					265:271	promising options	255:271	promising options	255:271	Although injectable bioactive hydrogels are promising options, they have decreased biomechanical performance.
33784250	10	58	dep	90	1280:1281	arg1	to					1277:1278	to	1277:1278	to	1277:1278	The sample that contained 10% microsphere had an enhanced storage modulus of up to 90 kPa.
33784250	10	59	theme	10	1223:1224	arg1	%					1225:1225	%	1225:1225	%	1225:1225	The sample that contained 10% microsphere had an enhanced storage modulus of up to 90 kPa.
33784250	11	60	theme	preliminary	1309:1319	arg1	differentiation					1321:1335	preliminary differentiation	1309:1335	preliminary differentiation	1309:1335	Biocompatibility and preliminary differentiation investigations revealed that this composite hydrogel might have potential benefits for cartilage tissue engineering.
33784250	4	61	theme	injectable	446:455	arg1	hydrogel					467:474	an injectable composite hydrogel	443:474	an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles	443:555	In this study, we created an injectable composite hydrogel from chitosan and human acellular cartilage extracellular matrix (ECM) particles.
33784250	6	62	theme	methods	856:862	arg1	combination					807:817	a combination	805:817	a combination of physical, chemical, and enzymatic methods	805:862	Articular cartilage from human donors was decellularized by a combination of physical, chemical, and enzymatic methods.
33784250	8	63	theme	time	1047:1050	arg1	terms					1012:1016	terms	1012:1016	terms of storage modulus, gelation time, biocompatibility, and differentiation potential	1012:1099	We characterized the composite constructs in terms of storage modulus, gelation time, biocompatibility, and differentiation potential.
33784250	5	64	theme	scaffold	735:742	arg1	blocks					721:726	the structural building blocks	697:726	the structural building blocks of the scaffold	697:742	In order to enhance its mechanical properties, we reinforced this hydrogel with microporous microspheres composed of the same materials as the structural building blocks of the scaffold.
33784250	9	65	from	increase	1164:1171	arg1	content					1188:1194	microsphere content	1176:1194	microsphere content	1176:1194	The results showed that mechanical behavior increased with an increase in microsphere content.
33784250	7	66	theme	content	958:964	arg1	assessment					940:949	assessment	940:949	assessment of DNA content	940:964	The decellularization efficiency was assessed by histological analysis and assessment of DNA content.
33784250	7	66	theme	content	958:964	arg1	analysis					927:934	histological analysis	914:934	histological analysis	914:934	The decellularization efficiency was assessed by histological analysis and assessment of DNA content.
33784250	10	67	theme	storage	1255:1261	arg1	modulus					1263:1269	an enhanced storage modulus	1243:1269	an enhanced storage modulus of up to 90 kPa	1243:1285	The sample that contained 10% microsphere had an enhanced storage modulus of up to 90 kPa.
33784250	6	68	from	donors	776:781	arg1	cartilage					755:763	Articular cartilage	745:763	Articular cartilage from human donors	745:781	Articular cartilage from human donors was decellularized by a combination of physical, chemical, and enzymatic methods.
33784250	10	69	theme	kPa	1283:1285	arg1	modulus					1263:1269	an enhanced storage modulus	1243:1269	an enhanced storage modulus of up to 90 kPa	1243:1285	The sample that contained 10% microsphere had an enhanced storage modulus of up to 90 kPa.
33784250	8	70	theme	potential	1091:1099	arg1	terms					1012:1016	terms	1012:1016	terms of storage modulus, gelation time, biocompatibility, and differentiation potential	1012:1099	We characterized the composite constructs in terms of storage modulus, gelation time, biocompatibility, and differentiation potential.
33784250	0	71	theme	scaffold	71:78	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Fabrication and characterization of an injectable reinforced composite scaffold for cartilage tissue engineering: an in vitro study.
33784250	0	71	theme	scaffold	71:78	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and characterization of an injectable reinforced composite scaffold for cartilage tissue engineering: an in vitro study.
33784250	0	72	dep	Fabrication	0:10	arg1	study					126:130	an in vitro study	114:130	Fabrication and characterization of an injectable reinforced composite scaffold for cartilage tissue engineering: an in vitro study.	0:131	Fabrication and characterization of an injectable reinforced composite scaffold for cartilage tissue engineering: an in vitro study.
33784250	8	73	theme	modulus	1029:1035	arg1	terms					1012:1016	terms	1012:1016	terms of storage modulus, gelation time, biocompatibility, and differentiation potential	1012:1099	We characterized the composite constructs in terms of storage modulus, gelation time, biocompatibility, and differentiation potential.
33784250	11	74	theme	differentiation	1321:1335	arg1	investigations					1337:1350	Biocompatibility and preliminary differentiation investigations	1288:1350	Biocompatibility and preliminary differentiation investigations	1288:1350	Biocompatibility and preliminary differentiation investigations revealed that this composite hydrogel might have potential benefits for cartilage tissue engineering.
31981909	0	0	theme	caproic	80:86	arg1	acid					88:91	caproic acid	80:91	caproic acid production in fermentation by Megasphaera elsdenii T81	80:146	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.
31981909	5	1	theme	current	940:946	arg1	price					955:959	the current market price	936:959	the current market price for petroleum-derived CA (~2500 USD/ton)	936:1000	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	2	2	with	medium	352:357	arg1	composition					373:383	a carbon composition	364:383	a carbon composition similar to that of JA	364:405	More CA was produced under the medium with the acid hydrolysate of JA than the comparative medium with a carbon composition similar to that of JA.
31981909	5	3	theme	production	881:890	arg1	scale					892:896	the production scale	877:896	the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton)	877:1000	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	2	4	theme	acid	308:311	arg1	hydrolysate					313:323	the acid hydrolysate	304:323	the acid hydrolysate of JA than the comparative medium with a carbon composition similar to that of JA	304:405	More CA was produced under the medium with the acid hydrolysate of JA than the comparative medium with a carbon composition similar to that of JA.
31981909	5	5	theme	pure	797:800	arg1	CA					802:803	pure CA	797:803	pure CA	797:803	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	0	6	theme	production	93:102	arg1	economics					67:75	the economics	63:75	the economics of caproic acid production in fermentation by Megasphaera elsdenii T81	63:146	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.
31981909	0	7	from	Impact	0:5	arg1	economics					67:75	the economics	63:75	the economics of caproic acid production in fermentation by Megasphaera elsdenii T81	63:146	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.
31981909	5	8	theme	estimated	810:818	arg1	cost					831:834	the estimated production cost	806:834	the estimated production cost for CA from dry JA	806:853	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	5	8	theme	estimated	810:818	arg1	CA					871:872	1869 USD/ton CA	858:872	1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton)	858:1000	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	0	9	theme	acid	88:91	arg1	production					93:102	caproic acid production	80:102	caproic acid production in fermentation by Megasphaera elsdenii T81	80:146	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.
31981909	5	10	theme	production	820:829	arg1	cost					831:834	the estimated production cost	806:834	the estimated production cost for CA from dry JA	806:853	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	5	10	theme	production	820:829	arg1	CA					871:872	1869 USD/ton CA	858:872	1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton)	858:1000	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	4	11	from	sucrose	653:659	arg1	production					677:686	CA production	674:686	CA production	674:686	The JA cost to produce 1 ton of CA is only 505 USD, which is much lower than that required for purchasing sucrose (860 USD) in CA production.
31981909	3	12	theme	mixed	491:495	arg1	solvent					497:503	a mixed solvent	489:503	a mixed solvent of alamine 336 in oleyl alcohol at 37 °C	489:544	CA was produced up to 13.0 g/L and 0.52 g/L/h with extractive fermentation using a mixed solvent of alamine 336 in oleyl alcohol at 37 °C.
31981909	3	13	from	37 °C	540:544	arg1	alcohol					529:535	oleyl alcohol at 37 °C	523:544	oleyl alcohol at 37 °C	523:544	CA was produced up to 13.0 g/L and 0.52 g/L/h with extractive fermentation using a mixed solvent of alamine 336 in oleyl alcohol at 37 °C.
31981909	3	13	from	37 °C	540:544	arg1	at					537:538	oleyl alcohol at 37 °C	523:544	oleyl alcohol at 37 °C	523:544	CA was produced up to 13.0 g/L and 0.52 g/L/h with extractive fermentation using a mixed solvent of alamine 336 in oleyl alcohol at 37 °C.
31981909	3	13	from	37 °C	540:544	arg1	oleyl					523:527	oleyl alcohol at 37 °C	523:544	oleyl alcohol at 37 °C	523:544	CA was produced up to 13.0 g/L and 0.52 g/L/h with extractive fermentation using a mixed solvent of alamine 336 in oleyl alcohol at 37 °C.
31981909	2	14	theme	carbon	366:371	arg1	composition					373:383	a carbon composition	364:383	a carbon composition similar to that of JA	364:405	More CA was produced under the medium with the acid hydrolysate of JA than the comparative medium with a carbon composition similar to that of JA.
31981909	5	15	from	JA	852:853	arg1	CA					840:841	CA	840:841	CA from dry JA	840:853	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	3	16	dep	13.0 g/L	430:437	arg1	up					424:425	up	424:425	up	424:425	CA was produced up to 13.0 g/L and 0.52 g/L/h with extractive fermentation using a mixed solvent of alamine 336 in oleyl alcohol at 37 °C.
31981909	2	17	theme	comparative	340:350	arg1	medium					352:357	the comparative medium	336:357	the comparative medium with a carbon composition similar to that of JA	336:405	More CA was produced under the medium with the acid hydrolysate of JA than the comparative medium with a carbon composition similar to that of JA.
31981909	5	18	theme	1869	858:861	arg1	cost					831:834	the estimated production cost	806:834	the estimated production cost for CA from dry JA	806:853	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	5	18	theme	1869	858:861	arg1	CA					871:872	1869 USD/ton CA	858:872	1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton)	858:1000	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	3	19	theme	alamine	508:514	arg1	solvent					497:503	a mixed solvent	489:503	a mixed solvent of alamine 336 in oleyl alcohol at 37 °C	489:544	CA was produced up to 13.0 g/L and 0.52 g/L/h with extractive fermentation using a mixed solvent of alamine 336 in oleyl alcohol at 37 °C.
31981909	5	20	theme	ton/year	906:913	arg1	scale					892:896	the production scale	877:896	the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton)	877:1000	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	5	21	theme	SuperPro	733:740	arg1	Designer					742:749	SuperPro Designer	733:749	SuperPro Designer	733:749	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	5	22	theme	market	948:953	arg1	price					955:959	the current market price	936:959	the current market price for petroleum-derived CA (~2500 USD/ton)	936:1000	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	4	23	theme	CA	579:580	arg1	ton					572:574	1 ton	570:574	1 ton of CA	570:580	The JA cost to produce 1 ton of CA is only 505 USD, which is much lower than that required for purchasing sucrose (860 USD) in CA production.
31981909	5	24	theme	dry	848:850	arg1	JA					852:853	dry JA	848:853	dry JA	848:853	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	0	25	theme	Megasphaera	123:133	arg1	elsdenii					135:142	Megasphaera elsdenii T81	123:146	Megasphaera elsdenii T81	123:146	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.
31981909	4	26	dep	cost	554:557	arg1	produce					562:568	produce	562:568	to produce 1 ton of CA	559:580	The JA cost to produce 1 ton of CA is only 505 USD, which is much lower than that required for purchasing sucrose (860 USD) in CA production.
31981909	0	27	theme	feedstocks	10:19	arg1	Impact					0:5	Impact	0:5	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.	0:147	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.
31981909	1	28	with	T81	204:206	arg1	JA					241:242	JA	241:242	JA	241:242	Caproic acid (CA) was produced by Megasphaera elsdenii T81 with Jerusalem artichoke tubers (JA) as a feedstock.
31981909	1	28	with	T81	204:206	arg1	tubers					233:238	Jerusalem artichoke tubers	213:238	Jerusalem artichoke tubers (JA)	213:243	Caproic acid (CA) was produced by Megasphaera elsdenii T81 with Jerusalem artichoke tubers (JA) as a feedstock.
31981909	2	29	with	medium	292:297	arg1	hydrolysate					313:323	the acid hydrolysate	304:323	the acid hydrolysate of JA than the comparative medium with a carbon composition similar to that of JA	304:405	More CA was produced under the medium with the acid hydrolysate of JA than the comparative medium with a carbon composition similar to that of JA.
31981909	1	30	theme	Megasphaera	183:193	arg1	T81					204:206	Megasphaera elsdenii T81	183:206	Megasphaera elsdenii T81 with Jerusalem artichoke tubers (JA)	183:243	Caproic acid (CA) was produced by Megasphaera elsdenii T81 with Jerusalem artichoke tubers (JA) as a feedstock.
31981909	0	31	theme	processing	36:45	arg1	technologies					47:58	downstream processing technologies	25:58	downstream processing technologies	25:58	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.
31981909	4	32	theme	JA	551:552	arg1	USD					594:596	only 505 USD	585:596	only 505 USD	585:596	The JA cost to produce 1 ton of CA is only 505 USD, which is much lower than that required for purchasing sucrose (860 USD) in CA production.
31981909	4	32	theme	JA	551:552	arg1	cost					554:557	The JA cost	547:557	The JA cost to produce 1 ton of CA	547:580	The JA cost to produce 1 ton of CA is only 505 USD, which is much lower than that required for purchasing sucrose (860 USD) in CA production.
31981909	3	33	theme	alcohol	529:535	arg1	37 °C					540:544	oleyl alcohol at 37 °C	523:544	oleyl alcohol at 37 °C	523:544	CA was produced up to 13.0 g/L and 0.52 g/L/h with extractive fermentation using a mixed solvent of alamine 336 in oleyl alcohol at 37 °C.
31981909	0	34	theme	downstream	25:34	arg1	technologies					47:58	downstream processing technologies	25:58	downstream processing technologies	25:58	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.
31981909	0	35	from	economics	67:75	arg1	fermentation					107:118	fermentation	107:118	fermentation	107:118	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.
31981909	3	36	theme	at	537:538	arg1	37 °C					540:544	oleyl alcohol at 37 °C	523:544	oleyl alcohol at 37 °C	523:544	CA was produced up to 13.0 g/L and 0.52 g/L/h with extractive fermentation using a mixed solvent of alamine 336 in oleyl alcohol at 37 °C.
31981909	5	37	theme	analysis	708:715	arg1	result					694:699	a result	692:699	a result of the analysis performed using SuperPro Designer	692:749	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	5	38	theme	petroleum-derived	965:981	arg1	CA					983:984	petroleum-derived CA	965:984	petroleum-derived CA (~2500 USD/ton)	965:1000	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	5	38	theme	petroleum-derived	965:981	arg1	USD/ton					993:999	~2500 USD/ton	987:999	~2500 USD/ton	987:999	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	5	39	theme	USD/ton	863:869	arg1	cost					831:834	the estimated production cost	806:834	the estimated production cost for CA from dry JA	806:853	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	5	39	theme	USD/ton	863:869	arg1	CA					871:872	1869 USD/ton CA	858:872	1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton)	858:1000	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	0	40	theme	technologies	47:58	arg1	Impact					0:5	Impact	0:5	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.	0:147	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.
31981909	0	41	from	fermentation	107:118	arg1	economics					67:75	the economics	63:75	the economics of caproic acid production in fermentation by Megasphaera elsdenii T81	63:146	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.
31981909	3	42	theme	oleyl	523:527	arg1	37 °C					540:544	oleyl alcohol at 37 °C	523:544	oleyl alcohol at 37 °C	523:544	CA was produced up to 13.0 g/L and 0.52 g/L/h with extractive fermentation using a mixed solvent of alamine 336 in oleyl alcohol at 37 °C.
31981909	5	43	theme	distillation	774:785	arg1	cost					766:769	the cost	762:769	the cost of distillation to obtain pure CA	762:803	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	3	44	from	solvent	497:503	arg1	37 °C					540:544	oleyl alcohol at 37 °C	523:544	oleyl alcohol at 37 °C	523:544	CA was produced up to 13.0 g/L and 0.52 g/L/h with extractive fermentation using a mixed solvent of alamine 336 in oleyl alcohol at 37 °C.
31981909	5	45	link	petroleum-derived	965:981	arg1	CA					983:984	petroleum-derived CA	965:984	petroleum-derived CA (~2500 USD/ton)	965:1000	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	5	45	link	petroleum-derived	965:981	arg1	USD/ton					993:999	~2500 USD/ton	987:999	~2500 USD/ton	987:999	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	5	46	dep	distillation	774:785	arg1	obtain					790:795	obtain	790:795	to obtain pure CA	787:803	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	0	47	from	production	93:102	arg1	fermentation					107:118	fermentation	107:118	fermentation	107:118	Impact of feedstocks and downstream processing technologies on the economics of caproic acid production in fermentation by Megasphaera elsdenii T81.
31981909	3	48	theme	extractive	459:468	arg1	fermentation					470:481	extractive fermentation	459:481	extractive fermentation using a mixed solvent of alamine 336 in oleyl alcohol at 37 °C	459:544	CA was produced up to 13.0 g/L and 0.52 g/L/h with extractive fermentation using a mixed solvent of alamine 336 in oleyl alcohol at 37 °C.
31981909	1	49	theme	Jerusalem	213:221	arg1	JA					241:242	JA	241:242	JA	241:242	Caproic acid (CA) was produced by Megasphaera elsdenii T81 with Jerusalem artichoke tubers (JA) as a feedstock.
31981909	1	49	theme	Jerusalem	213:221	arg1	tubers					233:238	Jerusalem artichoke tubers	213:238	Jerusalem artichoke tubers (JA)	213:243	Caproic acid (CA) was produced by Megasphaera elsdenii T81 with Jerusalem artichoke tubers (JA) as a feedstock.
31981909	4	50	theme	CA	674:675	arg1	production					677:686	CA production	674:686	CA production	674:686	The JA cost to produce 1 ton of CA is only 505 USD, which is much lower than that required for purchasing sucrose (860 USD) in CA production.
31981909	2	51	theme	similar	385:391	arg1	composition					373:383	a carbon composition	364:383	a carbon composition similar to that of JA	364:405	More CA was produced under the medium with the acid hydrolysate of JA than the comparative medium with a carbon composition similar to that of JA.
31981909	2	52	theme	JA	328:329	arg1	hydrolysate					313:323	the acid hydrolysate	304:323	the acid hydrolysate of JA than the comparative medium with a carbon composition similar to that of JA	304:405	More CA was produced under the medium with the acid hydrolysate of JA than the comparative medium with a carbon composition similar to that of JA.
31981909	1	53	theme	artichoke	223:231	arg1	JA					241:242	JA	241:242	JA	241:242	Caproic acid (CA) was produced by Megasphaera elsdenii T81 with Jerusalem artichoke tubers (JA) as a feedstock.
31981909	1	53	theme	artichoke	223:231	arg1	tubers					233:238	Jerusalem artichoke tubers	213:238	Jerusalem artichoke tubers (JA)	213:243	Caproic acid (CA) was produced by Megasphaera elsdenii T81 with Jerusalem artichoke tubers (JA) as a feedstock.
31981909	5	54	from	scale	892:896	arg1	cost					831:834	the estimated production cost	806:834	the estimated production cost for CA from dry JA	806:853	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	5	54	from	scale	892:896	arg1	CA					871:872	1869 USD/ton CA	858:872	1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton)	858:1000	As a result of the analysis performed using SuperPro Designer, including the cost of distillation to obtain pure CA, the estimated production cost for CA from dry JA is 1869 USD/ton CA at the production scale of 2000 ton/year, which is lower than the current market price for petroleum-derived CA (~2500 USD/ton).
31981909	1	55	dep	Megasphaera	183:193	arg1	elsdenii					195:202	elsdenii	195:202	elsdenii	195:202	Caproic acid (CA) was produced by Megasphaera elsdenii T81 with Jerusalem artichoke tubers (JA) as a feedstock.
31981909	1	56	theme	Caproic	149:155	arg1	CA					163:164	CA	163:164	CA	163:164	Caproic acid (CA) was produced by Megasphaera elsdenii T81 with Jerusalem artichoke tubers (JA) as a feedstock.
31981909	1	56	theme	Caproic	149:155	arg1	acid					157:160	Caproic acid	149:160	Caproic acid (CA)	149:165	Caproic acid (CA) was produced by Megasphaera elsdenii T81 with Jerusalem artichoke tubers (JA) as a feedstock.
31981909	1	56	theme	Caproic	149:155	arg1	feedstock					250:258	a feedstock	248:258	a feedstock	248:258	Caproic acid (CA) was produced by Megasphaera elsdenii T81 with Jerusalem artichoke tubers (JA) as a feedstock.
34780889	0	0	theme	sustainable	100:110	arg1	removal					112:118	highly efficient and sustainable removal	79:118	highly efficient and sustainable removal of cationic dyes	79:135	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads for highly efficient and sustainable removal of cationic dyes.
34780889	7	1	theme	adsorbents	1209:1218	arg1	preparation					1150:1160	the preparation	1146:1160	the preparation of high efficiency and recyclable cationic dye adsorbents with a large specific surface area	1146:1253	Therefore, this paper provides a strategy for the preparation of high efficiency and recyclable cationic dye adsorbents with a large specific surface area.
34780889	2	2	theme	CS	484:485	arg1	gel					488:490	sodium alginate (SA)/chitosan (CS) gel	453:490	sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	453:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	2	2	theme	CS	484:485	arg1	Fe3O4/CS					499:506	SA/GO@Fe3O4/CS	493:506	SA/GO@Fe3O4/CS	493:506	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	3	3	theme	Fe3O4	638:642	arg1	aggregation					623:633	the aggregation	619:633	the aggregation of Fe3O4	619:642	The GO@Fe3O4 sample was prepared based on GO by the chemical co-precipitation method, which not only reduced the aggregation of Fe3O4 but also increases the specific surface area of the composite gel beads.
34780889	1	4	theme	cationic	189:196	arg1	dyes					198:201	cationic dyes	189:201	cationic dyes	189:201	Developing recyclable and efficient adsorbents for cationic dyes removal from wastewater is crucial for ensuring green ecology and drinking water safety.
34780889	7	5	theme	recyclable	1185:1194	arg1	adsorbents					1209:1218	recyclable cationic dye adsorbents	1185:1218	recyclable cationic dye adsorbents	1185:1218	Therefore, this paper provides a strategy for the preparation of high efficiency and recyclable cationic dye adsorbents with a large specific surface area.
34780889	7	6	theme	cationic	1196:1203	arg1	adsorbents					1209:1218	recyclable cationic dye adsorbents	1185:1218	recyclable cationic dye adsorbents	1185:1218	Therefore, this paper provides a strategy for the preparation of high efficiency and recyclable cationic dye adsorbents with a large specific surface area.
34780889	5	7	theme	beads	904:908	arg1	capacity					873:880	the adsorption capacity	858:880	the adsorption capacity of SA/GO@Fe3O4/CS gel beads for MB, NR, and ST	858:927	The experimental results showed that the adsorption capacity of SA/GO@Fe3O4/CS gel beads for MB, NR, and ST reached 21.325 mg/g, 44.654 mg/g and 44.313 mg/g.
34780889	3	8	theme	GO	514:515	arg1	sample					523:528	The GO@Fe3O4 sample	510:528	The GO@Fe3O4 sample	510:528	The GO@Fe3O4 sample was prepared based on GO by the chemical co-precipitation method, which not only reduced the aggregation of Fe3O4 but also increases the specific surface area of the composite gel beads.
34780889	7	9	theme	large	1227:1231	arg1	area					1250:1253	a large specific surface area	1225:1253	a large specific surface area	1225:1253	Therefore, this paper provides a strategy for the preparation of high efficiency and recyclable cationic dye adsorbents with a large specific surface area.
34780889	7	10	theme	specific	1233:1240	arg1	area					1250:1253	a large specific surface area	1225:1253	a large specific surface area	1225:1253	Therefore, this paper provides a strategy for the preparation of high efficiency and recyclable cationic dye adsorbents with a large specific surface area.
34780889	3	11	theme	surface	676:682	arg1	area					684:687	the specific surface area	663:687	the specific surface area of the composite gel beads	663:714	The GO@Fe3O4 sample was prepared based on GO by the chemical co-precipitation method, which not only reduced the aggregation of Fe3O4 but also increases the specific surface area of the composite gel beads.
34780889	3	12	theme	@	516:516	arg1	sample					523:528	The GO@Fe3O4 sample	510:528	The GO@Fe3O4 sample	510:528	The GO@Fe3O4 sample was prepared based on GO by the chemical co-precipitation method, which not only reduced the aggregation of Fe3O4 but also increases the specific surface area of the composite gel beads.
34780889	0	13	theme	dyes	132:135	arg1	removal					112:118	highly efficient and sustainable removal	79:118	highly efficient and sustainable removal of cationic dyes	79:135	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads for highly efficient and sustainable removal of cationic dyes.
34780889	2	14	theme	magnetic	424:431	arg1	Fe3O4					415:419	graphene oxide (GO) modified Fe3O4	386:419	graphene oxide (GO) modified Fe3O4	386:419	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	2	14	theme	magnetic	424:431	arg1	nanoparticles					433:445	magnetic nanoparticles	424:445	magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	424:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	2	15	dep	oxide	395:399	arg1	GO					402:403	GO	402:403	GO	402:403	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	7	16	theme	high	1165:1168	arg1	efficiency					1170:1179	high efficiency	1165:1179	high efficiency	1165:1179	Therefore, this paper provides a strategy for the preparation of high efficiency and recyclable cationic dye adsorbents with a large specific surface area.
34780889	2	17	theme	modified	406:413	arg1	Fe3O4					415:419	graphene oxide (GO) modified Fe3O4	386:419	graphene oxide (GO) modified Fe3O4	386:419	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	2	17	theme	modified	406:413	arg1	nanoparticles					433:445	magnetic nanoparticles	424:445	magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	424:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	0	18	theme	cationic	123:130	arg1	dyes					132:135	cationic dyes	123:135	cationic dyes	123:135	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads for highly efficient and sustainable removal of cationic dyes.
34780889	6	19	theme	recovery	1085:1092	arg1	rate					1094:1097	a high recovery rate	1078:1097	a high recovery rate	1078:1097	After five recycles, the removal rates could still reach more than 90% of the original, exhibiting a high recovery rate.
34780889	2	20	theme	alginate	460:467	arg1	gel					488:490	sodium alginate (SA)/chitosan (CS) gel	453:490	sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	453:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	2	20	theme	alginate	460:467	arg1	Fe3O4/CS					499:506	SA/GO@Fe3O4/CS	493:506	SA/GO@Fe3O4/CS	493:506	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	2	21	theme	@	498:498	arg1	gel					488:490	sodium alginate (SA)/chitosan (CS) gel	453:490	sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	453:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	2	21	theme	@	498:498	arg1	Fe3O4/CS					499:506	SA/GO@Fe3O4/CS	493:506	SA/GO@Fe3O4/CS	493:506	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	0	22	theme	graphene	9:16	arg1	beads					69:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads	0:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads	0:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads for highly efficient and sustainable removal of cationic dyes.
34780889	3	23	theme	specific	667:674	arg1	area					684:687	the specific surface area	663:687	the specific surface area of the composite gel beads	663:714	The GO@Fe3O4 sample was prepared based on GO by the chemical co-precipitation method, which not only reduced the aggregation of Fe3O4 but also increases the specific surface area of the composite gel beads.
34780889	6	24	theme	high	1080:1083	arg1	rate					1094:1097	a high recovery rate	1078:1097	a high recovery rate	1078:1097	After five recycles, the removal rates could still reach more than 90% of the original, exhibiting a high recovery rate.
34780889	5	25	theme	experimental	825:836	arg1	results					838:844	The experimental results	821:844	The experimental results	821:844	The experimental results showed that the adsorption capacity of SA/GO@Fe3O4/CS gel beads for MB, NR, and ST reached 21.325 mg/g, 44.654 mg/g and 44.313 mg/g.
34780889	0	26	theme	Magnetic	0:7	arg1	beads					69:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads	0:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads	0:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads for highly efficient and sustainable removal of cationic dyes.
34780889	3	27	theme	composite	696:704	arg1	beads					710:714	the composite gel beads	692:714	the composite gel beads	692:714	The GO@Fe3O4 sample was prepared based on GO by the chemical co-precipitation method, which not only reduced the aggregation of Fe3O4 but also increases the specific surface area of the composite gel beads.
34780889	2	28	theme	gel	333:335	arg1	bead					337:340	a novel magnetic gel bead adsorbent	316:350	a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	316:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	0	29	theme	chitosan‑sodium	35:49	arg1	beads					69:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads	0:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads	0:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads for highly efficient and sustainable removal of cationic dyes.
34780889	3	30	theme	gel	706:708	arg1	beads					710:714	the composite gel beads	692:714	the composite gel beads	692:714	The GO@Fe3O4 sample was prepared based on GO by the chemical co-precipitation method, which not only reduced the aggregation of Fe3O4 but also increases the specific surface area of the composite gel beads.
34780889	7	31	theme	efficiency	1170:1179	arg1	preparation					1150:1160	the preparation	1146:1160	the preparation of high efficiency and recyclable cationic dye adsorbents with a large specific surface area	1146:1253	Therefore, this paper provides a strategy for the preparation of high efficiency and recyclable cationic dye adsorbents with a large specific surface area.
34780889	2	32	theme	magnetic	324:331	arg1	bead					337:340	a novel magnetic gel bead adsorbent	316:350	a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	316:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	4	33	used	used	745:748	arg2	beads					734:738	The prepared gel beads	717:738	The prepared gel beads	717:738	The prepared gel beads were used to adsorb methylene blue (MB), neutral red (NR), and safranine T (ST).
34780889	0	34	theme	oxide-containing	18:33	arg1	beads					69:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads	0:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads	0:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads for highly efficient and sustainable removal of cationic dyes.
34780889	4	35	theme	prepared	721:728	arg1	beads					734:738	The prepared gel beads	717:738	The prepared gel beads	717:738	The prepared gel beads were used to adsorb methylene blue (MB), neutral red (NR), and safranine T (ST).
34780889	2	36	theme	novel	318:322	arg1	bead					337:340	a novel magnetic gel bead adsorbent	316:350	a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	316:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	1	37	theme	efficient	164:172	arg1	adsorbents					174:183	recyclable and efficient adsorbents	149:183	recyclable and efficient adsorbents for cationic dyes	149:201	Developing recyclable and efficient adsorbents for cationic dyes removal from wastewater is crucial for ensuring green ecology and drinking water safety.
34780889	0	38	theme	hydrogel	60:67	arg1	beads					69:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads	0:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads	0:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads for highly efficient and sustainable removal of cationic dyes.
34780889	5	39	theme	@	890:890	arg1	beads					904:908	SA/GO@Fe3O4/CS gel beads	885:908	SA/GO@Fe3O4/CS gel beads	885:908	The experimental results showed that the adsorption capacity of SA/GO@Fe3O4/CS gel beads for MB, NR, and ST reached 21.325 mg/g, 44.654 mg/g and 44.313 mg/g.
34780889	6	40	theme	original	1057:1064	arg1	%					1048:1048	more than 90%	1036:1048	more than 90% of the original	1036:1064	After five recycles, the removal rates could still reach more than 90% of the original, exhibiting a high recovery rate.
34780889	6	40	theme	original	1057:1064	arg1	original					1057:1064	original	1057:1064	original	1057:1064	After five recycles, the removal rates could still reach more than 90% of the original, exhibiting a high recovery rate.
34780889	5	41	theme	Fe3O4/CS	891:898	arg1	beads					904:908	SA/GO@Fe3O4/CS gel beads	885:908	SA/GO@Fe3O4/CS gel beads	885:908	The experimental results showed that the adsorption capacity of SA/GO@Fe3O4/CS gel beads for MB, NR, and ST reached 21.325 mg/g, 44.654 mg/g and 44.313 mg/g.
34780889	0	42	theme	alginate	51:58	arg1	beads					69:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads	0:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads	0:73	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads for highly efficient and sustainable removal of cationic dyes.
34780889	2	43	theme	/chitosan	473:481	arg1	gel					488:490	sodium alginate (SA)/chitosan (CS) gel	453:490	sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	453:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	2	43	theme	/chitosan	473:481	arg1	Fe3O4/CS					499:506	SA/GO@Fe3O4/CS	493:506	SA/GO@Fe3O4/CS	493:506	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	0	44	dep	beads	69:73	arg1	removal					112:118	highly efficient and sustainable removal	79:118	highly efficient and sustainable removal of cationic dyes	79:135	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads for highly efficient and sustainable removal of cationic dyes.
34780889	2	45	theme	SA/GO	493:497	arg1	gel					488:490	sodium alginate (SA)/chitosan (CS) gel	453:490	sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	453:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	2	45	theme	SA/GO	493:497	arg1	Fe3O4/CS					499:506	SA/GO@Fe3O4/CS	493:506	SA/GO@Fe3O4/CS	493:506	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	1	46	dep	ecology	257:263	arg1	safety					284:289	safety	284:289	safety	284:289	Developing recyclable and efficient adsorbents for cationic dyes removal from wastewater is crucial for ensuring green ecology and drinking water safety.
34780889	4	47	theme	blue	770:773	arg1	methylene					760:768	methylene blue	760:773	methylene blue (MB)	760:778	The prepared gel beads were used to adsorb methylene blue (MB), neutral red (NR), and safranine T (ST).
34780889	4	47	theme	blue	770:773	arg1	MB					776:777	MB	776:777	MB	776:777	The prepared gel beads were used to adsorb methylene blue (MB), neutral red (NR), and safranine T (ST).
34780889	7	48	with	preparation	1150:1160	arg1	area					1250:1253	a large specific surface area	1225:1253	a large specific surface area	1225:1253	Therefore, this paper provides a strategy for the preparation of high efficiency and recyclable cationic dye adsorbents with a large specific surface area.
34780889	2	49	theme	sodium	453:458	arg1	gel					488:490	sodium alginate (SA)/chitosan (CS) gel	453:490	sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	453:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	2	49	theme	sodium	453:458	arg1	Fe3O4/CS					499:506	SA/GO@Fe3O4/CS	493:506	SA/GO@Fe3O4/CS	493:506	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	3	50	theme	beads	710:714	arg1	area					684:687	the specific surface area	663:687	the specific surface area of the composite gel beads	663:714	The GO@Fe3O4 sample was prepared based on GO by the chemical co-precipitation method, which not only reduced the aggregation of Fe3O4 but also increases the specific surface area of the composite gel beads.
34780889	2	51	theme	SA	470:471	arg1	gel					488:490	sodium alginate (SA)/chitosan (CS) gel	453:490	sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	453:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	2	51	theme	SA	470:471	arg1	Fe3O4/CS					499:506	SA/GO@Fe3O4/CS	493:506	SA/GO@Fe3O4/CS	493:506	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	7	52	theme	dye	1205:1207	arg1	adsorbents					1209:1218	recyclable cationic dye adsorbents	1185:1218	recyclable cationic dye adsorbents	1185:1218	Therefore, this paper provides a strategy for the preparation of high efficiency and recyclable cationic dye adsorbents with a large specific surface area.
34780889	3	53	theme	chemical	562:569	arg1	method					588:593	the chemical co-precipitation method	558:593	the chemical co-precipitation method	558:593	The GO@Fe3O4 sample was prepared based on GO by the chemical co-precipitation method, which not only reduced the aggregation of Fe3O4 but also increases the specific surface area of the composite gel beads.
34780889	4	54	theme	safranine	803:811	arg1	T					813:813	safranine T	803:813	safranine T (ST)	803:818	The prepared gel beads were used to adsorb methylene blue (MB), neutral red (NR), and safranine T (ST).
34780889	5	55	theme	gel	900:902	arg1	beads					904:908	SA/GO@Fe3O4/CS gel beads	885:908	SA/GO@Fe3O4/CS gel beads	885:908	The experimental results showed that the adsorption capacity of SA/GO@Fe3O4/CS gel beads for MB, NR, and ST reached 21.325 mg/g, 44.654 mg/g and 44.313 mg/g.
34780889	3	56	theme	co-precipitation	571:586	arg1	method					588:593	the chemical co-precipitation method	558:593	the chemical co-precipitation method	558:593	The GO@Fe3O4 sample was prepared based on GO by the chemical co-precipitation method, which not only reduced the aggregation of Fe3O4 but also increases the specific surface area of the composite gel beads.
34780889	4	57	dep	T	813:813	arg1	ST					816:817	ST	816:817	ST	816:817	The prepared gel beads were used to adsorb methylene blue (MB), neutral red (NR), and safranine T (ST).
34780889	1	58	theme	recyclable	149:158	arg1	adsorbents					174:183	recyclable and efficient adsorbents	149:183	recyclable and efficient adsorbents for cationic dyes	149:201	Developing recyclable and efficient adsorbents for cationic dyes removal from wastewater is crucial for ensuring green ecology and drinking water safety.
34780889	3	59	theme	Fe3O4	517:521	arg1	sample					523:528	The GO@Fe3O4 sample	510:528	The GO@Fe3O4 sample	510:528	The GO@Fe3O4 sample was prepared based on GO by the chemical co-precipitation method, which not only reduced the aggregation of Fe3O4 but also increases the specific surface area of the composite gel beads.
34780889	1	60	theme	green	251:255	arg1	ecology					257:263	green ecology	251:263	green ecology	251:263	Developing recyclable and efficient adsorbents for cationic dyes removal from wastewater is crucial for ensuring green ecology and drinking water safety.
34780889	5	61	theme	adsorption	862:871	arg1	capacity					873:880	the adsorption capacity	858:880	the adsorption capacity of SA/GO@Fe3O4/CS gel beads for MB, NR, and ST	858:927	The experimental results showed that the adsorption capacity of SA/GO@Fe3O4/CS gel beads for MB, NR, and ST reached 21.325 mg/g, 44.654 mg/g and 44.313 mg/g.
34780889	4	62	theme	gel	730:732	arg1	beads					734:738	The prepared gel beads	717:738	The prepared gel beads	717:738	The prepared gel beads were used to adsorb methylene blue (MB), neutral red (NR), and safranine T (ST).
34780889	7	63	theme	surface	1242:1248	arg1	area					1250:1253	a large specific surface area	1225:1253	a large specific surface area	1225:1253	Therefore, this paper provides a strategy for the preparation of high efficiency and recyclable cationic dye adsorbents with a large specific surface area.
34780889	2	64	theme	adsorbent	342:350	arg1	bead					337:340	a novel magnetic gel bead adsorbent	316:350	a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	316:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	0	65	theme	efficient	86:94	arg1	removal					112:118	highly efficient and sustainable removal	79:118	highly efficient and sustainable removal of cationic dyes	79:135	Magnetic graphene oxide-containing chitosan‑sodium alginate hydrogel beads for highly efficient and sustainable removal of cationic dyes.
34780889	5	66	theme	SA/GO	885:889	arg1	beads					904:908	SA/GO@Fe3O4/CS gel beads	885:908	SA/GO@Fe3O4/CS gel beads	885:908	The experimental results showed that the adsorption capacity of SA/GO@Fe3O4/CS gel beads for MB, NR, and ST reached 21.325 mg/g, 44.654 mg/g and 44.313 mg/g.
34780889	1	67	from	wastewater	216:225	arg1	removal					203:209	removal	203:209	removal from wastewater	203:225	Developing recyclable and efficient adsorbents for cationic dyes removal from wastewater is crucial for ensuring green ecology and drinking water safety.
34780889	2	68	theme	oxide	395:399	arg1	Fe3O4					415:419	graphene oxide (GO) modified Fe3O4	386:419	graphene oxide (GO) modified Fe3O4	386:419	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	2	68	theme	oxide	395:399	arg1	nanoparticles					433:445	magnetic nanoparticles	424:445	magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS)	424:507	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	6	69	theme	removal	1004:1010	arg1	rates					1012:1016	the removal rates	1000:1016	the removal rates	1000:1016	After five recycles, the removal rates could still reach more than 90% of the original, exhibiting a high recovery rate.
34780889	1	70	dep	crucial	230:236	arg1	Developing					138:147	Developing	138:147	Developing recyclable and efficient adsorbents for cationic dyes	138:201	Developing recyclable and efficient adsorbents for cationic dyes removal from wastewater is crucial for ensuring green ecology and drinking water safety.
34780889	2	71	theme	graphene	386:393	arg1	oxide					395:399	graphene oxide	386:399	graphene oxide (GO) modified Fe3O4	386:419	Herein, we demonstrated a novel magnetic gel bead adsorbent that was synthesized by employing graphene oxide (GO) modified Fe3O4 as magnetic nanoparticles doped sodium alginate (SA)/chitosan (CS) gel (SA/GO@Fe3O4/CS).
34780889	1	72	theme	drinking	269:276	arg1	water					278:282	drinking water	269:282	drinking water	269:282	Developing recyclable and efficient adsorbents for cationic dyes removal from wastewater is crucial for ensuring green ecology and drinking water safety.
33644618	6	0	theme	N-glycosylation	1027:1041	arg1	degrees					1085:1091	lower degrees	1079:1091	lower degrees of sulfonation	1079:1106	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	6	0	theme	N-glycosylation	1027:1041	arg1	degrees					1051:1057	higher degrees	1044:1057	higher degrees of sialylation	1044:1072	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	6	0	theme	N-glycosylation	1027:1041	arg1	degrees					1016:1022	lower degrees	1010:1022	lower degrees of N-glycosylation	1010:1041	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	6	1	theme	euthyroid	1116:1124	arg1	individuals					1126:1136	euthyroid individuals	1116:1136	euthyroid individuals	1116:1136	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	6	2	from	molecules	980:988	arg1	patients					997:1004	sPH patients	993:1004	sPH patients	993:1004	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	2	3	theme	different	254:262	arg1	glycoforms					268:277	2 different TSH glycoforms	252:277	2 different TSH glycoforms	252:277	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	9	4	theme	target	1622:1627	arg1	cells					1629:1633	the target cells	1618:1633	the target cells	1618:1633	This glycan pattern favors a prolonged half-life in the circulation combined with lower in vitro biopotency at the target cells.
33644618	3	5	theme	glycan	530:535	arg1	composition					537:547	glycan composition	530:547	glycan composition	530:547	OBJECTIVE Characterize N-glycosylation and glycan composition of circulating TSH molecules and determine the effects during levothyroxine treatment in patients with sPH.
33644618	8	6	from	molecules	1363:1371	arg1	hypothyroidism					1391:1404	severe primary hypothyroidism	1376:1404	severe primary hypothyroidism	1376:1404	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism were less N- glycosylated, more sialylated, and less sulfonated compared with euthyroid individuals.
33644618	6	7	theme	lower	1079:1083	arg1	degrees					1085:1091	lower degrees	1079:1091	lower degrees of sulfonation	1079:1106	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	1	8	theme	primary	103:109	arg1	sPH					127:129	sPH	127:129	sPH	127:129	CONTEXT In severe primary hypothyroidism (sPH), the serum thyrotropin (TSH) levels are elevated with an increased degree of sialylation.
33644618	1	8	theme	primary	103:109	arg1	hypothyroidism					111:124	severe primary hypothyroidism	96:124	severe primary hypothyroidism (sPH)	96:130	CONTEXT In severe primary hypothyroidism (sPH), the serum thyrotropin (TSH) levels are elevated with an increased degree of sialylation.
33644618	0	9	theme	Glycan	32:37	arg1	Composition					39:49	Glycan Composition	32:49	Glycan Composition	32:49	Thyrotropin N-glycosylation and Glycan Composition in Severe Primary Hypothyroidism.
33644618	8	10	gly	glycosylated	1419:1430	arg1	CONCLUSIONS					1331:1341	CONCLUSIONS	1331:1341	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism	1331:1404	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism were less N- glycosylated, more sialylated, and less sulfonated compared with euthyroid individuals.
33644618	3	11	from	effects	596:602	arg1	patients					638:645	patients	638:645	patients with sPH	638:654	OBJECTIVE Characterize N-glycosylation and glycan composition of circulating TSH molecules and determine the effects during levothyroxine treatment in patients with sPH.
33644618	8	12	theme	primary	1383:1389	arg1	hypothyroidism					1391:1404	severe primary hypothyroidism	1376:1404	severe primary hypothyroidism	1376:1404	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism were less N- glycosylated, more sialylated, and less sulfonated compared with euthyroid individuals.
33644618	1	13	dep	CONTEXT	85:91	arg1	sPH					127:129	sPH	127:129	sPH	127:129	CONTEXT In severe primary hypothyroidism (sPH), the serum thyrotropin (TSH) levels are elevated with an increased degree of sialylation.
33644618	1	13	dep	CONTEXT	85:91	arg1	hypothyroidism					111:124	severe primary hypothyroidism	96:124	severe primary hypothyroidism (sPH)	96:130	CONTEXT In severe primary hypothyroidism (sPH), the serum thyrotropin (TSH) levels are elevated with an increased degree of sialylation.
33644618	3	14	gly	N-glycosylation	510:524	arg1	molecules					568:576	circulating TSH molecules	552:576	circulating TSH molecules	552:576	OBJECTIVE Characterize N-glycosylation and glycan composition of circulating TSH molecules and determine the effects during levothyroxine treatment in patients with sPH.
33644618	4	15	theme	METHODS	657:663	arg1	samples					671:677	METHODS Serum samples	657:677	METHODS Serum samples	657:677	METHODS Serum samples were obtained from 25 patients with sPH, from 159 euthyroid individuals, and from 12 women during treatment with levothyroxine for sPH.
33644618	2	16	theme	circulating	226:236	arg1	TSH					238:240	The circulating TSH	222:240	The circulating TSH	222:240	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	8	17	dep	CONCLUSIONS	1331:1341	arg1	majority					1347:1354	The majority	1343:1354	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism	1331:1404	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism were less N- glycosylated, more sialylated, and less sulfonated compared with euthyroid individuals.
33644618	6	18	contain	had	1006:1008	arg2	degrees					1016:1022	lower degrees	1010:1022	lower degrees of N-glycosylation	1010:1041	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	6	18	contain	had	1006:1008	arg2	degrees					1085:1091	lower degrees	1079:1091	lower degrees of sulfonation	1079:1106	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	6	18	contain	had	1006:1008	arg1	molecules					980:988	The circulating TSH molecules	960:988	The circulating TSH molecules in sPH patients	960:1004	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	6	18	contain	had	1006:1008	arg2	degrees					1051:1057	higher degrees	1044:1057	higher degrees of sialylation	1044:1072	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	2	19	with	TSHdi	280:284	arg1	methods					325:331	methods	325:331	methods	325:331	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	2	19	with	TSHdi	280:284	arg1	N-glycans					311:319	3 N-glycans	309:319	3 N-glycans	309:319	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	2	19	with	TSHdi	280:284	arg1	2					291:291	2	291:291	2	291:291	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	7	20	gly	restored	1152:1159	arg1	levels					1240:1245	low free thyroxine (FT4) levels	1215:1245	low free thyroxine (FT4) levels	1215:1245	Levothyroxin restored sialylation and sulfonation of the glycans already at low free thyroxine (FT4) levels, while degree of N-glycosylation was not restored until the FT4 levels were normal.
33644618	10	21	theme	low	1752:1754	arg1	levels					1760:1765	low FT4 levels	1752:1765	low FT4 levels	1752:1765	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33644618	5	22	theme	SA	915:916	arg1	concentrations					846:859	concentrations	846:859	concentrations of TSHdi and TSHtri	846:879	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	5	22	theme	SA	915:916	arg1	contents					898:905	their contents	892:905	their contents of AMS, SA, and SU residues	892:933	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	5	22	theme	SA	915:916	arg1	Degrees					815:821	Degrees	815:821	Degrees of N-glycosylation	815:840	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	6	23	theme	lower	1010:1014	arg1	degrees					1016:1022	lower degrees	1010:1022	lower degrees of N-glycosylation	1010:1041	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	0	24	from	Composition	39:49	arg1	Hypothyroidism					69:82	Severe Primary Hypothyroidism	54:82	Severe Primary Hypothyroidism	54:82	Thyrotropin N-glycosylation and Glycan Composition in Severe Primary Hypothyroidism.
33644618	0	25	theme	Thyrotropin	0:10	arg1	N-glycosylation					12:26	Thyrotropin N-glycosylation	0:26	Thyrotropin N-glycosylation	0:26	Thyrotropin N-glycosylation and Glycan Composition in Severe Primary Hypothyroidism.
33644618	8	26	dep	glycosylated	1419:1430	arg1	N-					1416:1417	less N-	1411:1417	less N-	1411:1417	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism were less N- glycosylated, more sialylated, and less sulfonated compared with euthyroid individuals.
33644618	9	27	theme	glycan	1512:1517	arg1	pattern					1519:1525	This glycan pattern	1507:1525	This glycan pattern	1507:1525	This glycan pattern favors a prolonged half-life in the circulation combined with lower in vitro biopotency at the target cells.
33644618	9	28	dep	in	1595:1596	arg1	vitro					1598:1602	vitro	1598:1602	vitro	1598:1602	This glycan pattern favors a prolonged half-life in the circulation combined with lower in vitro biopotency at the target cells.
33644618	5	29	theme	AMS	910:912	arg1	concentrations					846:859	concentrations	846:859	concentrations of TSHdi and TSHtri	846:879	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	5	29	theme	AMS	910:912	arg1	contents					898:905	their contents	892:905	their contents of AMS, SA, and SU residues	892:933	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	5	29	theme	AMS	910:912	arg1	Degrees					815:821	Degrees	815:821	Degrees of N-glycosylation	815:840	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	10	30	dep	sialylation	1688:1698	arg1	the					1684:1686	the	1684:1686	the	1684:1686	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33644618	2	31	theme	anionic	379:385	arg1	AMS					404:406	AMS	404:406	AMS	404:406	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	2	31	theme	anionic	379:385	arg1	monosaccharides					387:401	anionic monosaccharides	379:401	anionic monosaccharides (AMS)	379:407	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	0	32	gly	N-glycosylation	12:26	arg1	Hypothyroidism					69:82	Severe Primary Hypothyroidism	54:82	Severe Primary Hypothyroidism	54:82	Thyrotropin N-glycosylation and Glycan Composition in Severe Primary Hypothyroidism.
33644618	6	33	theme	TSH	976:978	arg1	molecules					980:988	The circulating TSH molecules	960:988	The circulating TSH molecules in sPH patients	960:1004	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	0	34	theme	Severe	54:59	arg1	Hypothyroidism					69:82	Severe Primary Hypothyroidism	54:82	Severe Primary Hypothyroidism	54:82	Thyrotropin N-glycosylation and Glycan Composition in Severe Primary Hypothyroidism.
33644618	6	35	theme	sialylation	1062:1072	arg1	degrees					1085:1091	lower degrees	1079:1091	lower degrees of sulfonation	1079:1106	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	6	35	theme	sialylation	1062:1072	arg1	degrees					1051:1057	higher degrees	1044:1057	higher degrees of sialylation	1044:1072	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	6	35	theme	sialylation	1062:1072	arg1	degrees					1016:1022	lower degrees	1010:1022	lower degrees of N-glycosylation	1010:1041	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	9	36	theme	prolonged	1536:1544	arg1	half-life					1546:1554	a prolonged half-life	1534:1554	a prolonged half-life	1534:1554	This glycan pattern favors a prolonged half-life in the circulation combined with lower in vitro biopotency at the target cells.
33644618	5	37	theme	residues	926:933	arg1	concentrations					846:859	concentrations	846:859	concentrations of TSHdi and TSHtri	846:879	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	5	37	theme	residues	926:933	arg1	contents					898:905	their contents	892:905	their contents of AMS, SA, and SU residues	892:933	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	5	37	theme	residues	926:933	arg1	Degrees					815:821	Degrees	815:821	Degrees of N-glycosylation	815:840	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	7	38	theme	free	1219:1222	arg1	FT4					1235:1237	FT4	1235:1237	FT4	1235:1237	Levothyroxin restored sialylation and sulfonation of the glycans already at low free thyroxine (FT4) levels, while degree of N-glycosylation was not restored until the FT4 levels were normal.
33644618	7	38	theme	free	1219:1222	arg1	thyroxine					1224:1232	free thyroxine	1219:1232	low free thyroxine (FT4) levels	1215:1245	Levothyroxin restored sialylation and sulfonation of the glycans already at low free thyroxine (FT4) levels, while degree of N-glycosylation was not restored until the FT4 levels were normal.
33644618	8	39	theme	molecules	1363:1371	arg1	majority					1347:1354	The majority	1343:1354	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism	1331:1404	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism were less N- glycosylated, more sialylated, and less sulfonated compared with euthyroid individuals.
33644618	10	40	theme	sPH	1670:1672	arg1	patients					1674:1681	sPH patients	1670:1681	sPH patients	1670:1681	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33644618	9	41	theme	in	1595:1596	arg1	biopotency					1604:1613	in vitro biopotency	1595:1613	lower in vitro biopotency at the target cells	1589:1633	This glycan pattern favors a prolonged half-life in the circulation combined with lower in vitro biopotency at the target cells.
33644618	7	42	theme	glycans	1196:1202	arg1	sulfonation					1177:1187	sulfonation	1177:1187	sulfonation	1177:1187	Levothyroxin restored sialylation and sulfonation of the glycans already at low free thyroxine (FT4) levels, while degree of N-glycosylation was not restored until the FT4 levels were normal.
33644618	7	42	theme	glycans	1196:1202	arg1	sialylation					1161:1171	sialylation	1161:1171	sialylation	1161:1171	Levothyroxin restored sialylation and sulfonation of the glycans already at low free thyroxine (FT4) levels, while degree of N-glycosylation was not restored until the FT4 levels were normal.
33644618	2	43	gly	glycoforms	268:277	arg1	TSH					264:266	2 different TSH glycoforms	252:277	2 different TSH glycoforms	252:277	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	2	44	theme	TSH	264:266	arg1	glycoforms					268:277	2 different TSH glycoforms	252:277	2 different TSH glycoforms	252:277	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	3	45	with	patients	638:645	arg1	sPH					652:654	sPH	652:654	sPH	652:654	OBJECTIVE Characterize N-glycosylation and glycan composition of circulating TSH molecules and determine the effects during levothyroxine treatment in patients with sPH.
33644618	6	46	theme	sulfonation	1096:1106	arg1	degrees					1085:1091	lower degrees	1079:1091	lower degrees of sulfonation	1079:1106	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	6	46	theme	sulfonation	1096:1106	arg1	degrees					1051:1057	higher degrees	1044:1057	higher degrees of sialylation	1044:1072	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	6	46	theme	sulfonation	1096:1106	arg1	degrees					1016:1022	lower degrees	1010:1022	lower degrees of N-glycosylation	1010:1041	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	5	47	theme	N-glycosylation	826:840	arg1	concentrations					846:859	concentrations	846:859	concentrations of TSHdi and TSHtri	846:879	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	5	47	theme	N-glycosylation	826:840	arg1	contents					898:905	their contents	892:905	their contents of AMS, SA, and SU residues	892:933	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	5	47	theme	N-glycosylation	826:840	arg1	Degrees					815:821	Degrees	815:821	Degrees of N-glycosylation	815:840	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	10	48	theme	glycans	1719:1725	arg1	sulfonation					1704:1714	sulfonation	1704:1714	sulfonation	1704:1714	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33644618	10	48	theme	glycans	1719:1725	arg1	sialylation					1688:1698	sialylation	1688:1698	sialylation	1688:1698	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33644618	8	49	theme	severe	1376:1381	arg1	hypothyroidism					1391:1404	severe primary hypothyroidism	1376:1404	severe primary hypothyroidism	1376:1404	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism were less N- glycosylated, more sialylated, and less sulfonated compared with euthyroid individuals.
33644618	3	50	theme	circulating	552:562	arg1	molecules					568:576	circulating TSH molecules	552:576	circulating TSH molecules	552:576	OBJECTIVE Characterize N-glycosylation and glycan composition of circulating TSH molecules and determine the effects during levothyroxine treatment in patients with sPH.
33644618	8	51	from	majority	1347:1354	arg1	hypothyroidism					1391:1404	severe primary hypothyroidism	1376:1404	severe primary hypothyroidism	1376:1404	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism were less N- glycosylated, more sialylated, and less sulfonated compared with euthyroid individuals.
33644618	1	52	theme	increased	189:197	arg1	degree					199:204	an increased degree	186:204	an increased degree of sialylation	186:219	CONTEXT In severe primary hypothyroidism (sPH), the serum thyrotropin (TSH) levels are elevated with an increased degree of sialylation.
33644618	5	53	theme	TSHtri	874:879	arg1	concentrations					846:859	concentrations	846:859	concentrations of TSHdi and TSHtri	846:879	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	5	53	theme	TSHtri	874:879	arg1	contents					898:905	their contents	892:905	their contents of AMS, SA, and SU residues	892:933	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	5	53	theme	TSHtri	874:879	arg1	Degrees					815:821	Degrees	815:821	Degrees of N-glycosylation	815:840	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	7	54	theme	FT4	1307:1309	arg1	normal					1323:1328	normal	1323:1328	normal	1323:1328	Levothyroxin restored sialylation and sulfonation of the glycans already at low free thyroxine (FT4) levels, while degree of N-glycosylation was not restored until the FT4 levels were normal.
33644618	7	54	theme	FT4	1307:1309	arg1	levels					1311:1316	the FT4 levels	1303:1316	the FT4 levels	1303:1316	Levothyroxin restored sialylation and sulfonation of the glycans already at low free thyroxine (FT4) levels, while degree of N-glycosylation was not restored until the FT4 levels were normal.
33644618	4	55	with	patients	701:708	arg1	sPH					715:717	sPH	715:717	sPH	715:717	METHODS Serum samples were obtained from 25 patients with sPH, from 159 euthyroid individuals, and from 12 women during treatment with levothyroxine for sPH.
33644618	8	56	gly	sialylated	1438:1447	arg1	CONCLUSIONS					1331:1341	CONCLUSIONS	1331:1341	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism	1331:1404	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism were less N- glycosylated, more sialylated, and less sulfonated compared with euthyroid individuals.
33644618	6	57	theme	circulating	964:974	arg1	molecules					980:988	The circulating TSH molecules	960:988	The circulating TSH molecules in sPH patients	960:1004	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	4	58	with	treatment	777:785	arg1	levothyroxine					792:804	levothyroxine	792:804	levothyroxine for sPH	792:812	METHODS Serum samples were obtained from 25 patients with sPH, from 159 euthyroid individuals, and from 12 women during treatment with levothyroxine for sPH.
33644618	8	59	from	hypothyroidism	1391:1404	arg1	majority					1347:1354	The majority	1343:1354	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism	1331:1404	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism were less N- glycosylated, more sialylated, and less sulfonated compared with euthyroid individuals.
33644618	3	60	theme	molecules	568:576	arg1	N-glycosylation					510:524	N-glycosylation	510:524	N-glycosylation	510:524	OBJECTIVE Characterize N-glycosylation and glycan composition of circulating TSH molecules and determine the effects during levothyroxine treatment in patients with sPH.
33644618	3	60	theme	molecules	568:576	arg1	composition					537:547	glycan composition	530:547	glycan composition	530:547	OBJECTIVE Characterize N-glycosylation and glycan composition of circulating TSH molecules and determine the effects during levothyroxine treatment in patients with sPH.
33644618	1	61	theme	serum	137:141	arg1	thyrotropin					143:153	serum thyrotropin	137:153	the serum thyrotropin (TSH) levels	133:166	CONTEXT In severe primary hypothyroidism (sPH), the serum thyrotropin (TSH) levels are elevated with an increased degree of sialylation.
33644618	1	61	theme	serum	137:141	arg1	TSH					156:158	TSH	156:158	TSH	156:158	CONTEXT In severe primary hypothyroidism (sPH), the serum thyrotropin (TSH) levels are elevated with an increased degree of sialylation.
33644618	5	62	theme	TSHdi	864:868	arg1	concentrations					846:859	concentrations	846:859	concentrations of TSHdi and TSHtri	846:879	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	5	62	theme	TSHdi	864:868	arg1	contents					898:905	their contents	892:905	their contents of AMS, SA, and SU residues	892:933	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	5	62	theme	TSHdi	864:868	arg1	Degrees					815:821	Degrees	815:821	Degrees of N-glycosylation	815:840	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	0	63	from	N-glycosylation	12:26	arg1	Hypothyroidism					69:82	Severe Primary Hypothyroidism	54:82	Severe Primary Hypothyroidism	54:82	Thyrotropin N-glycosylation and Glycan Composition in Severe Primary Hypothyroidism.
33644618	4	64	theme	Serum	665:669	arg1	samples					671:677	METHODS Serum samples	657:677	METHODS Serum samples	657:677	METHODS Serum samples were obtained from 25 patients with sPH, from 159 euthyroid individuals, and from 12 women during treatment with levothyroxine for sPH.
33644618	2	65	dep	acid	426:429	arg1	residues					477:484	residues	477:484	residues	477:484	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	6	66	dep	RESULTS	952:958	arg1	had					1006:1008	had	1006:1008	had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals	1006:1136	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	2	67	theme	sulfonated	440:449	arg1	N-acetylglactosamine					451:470	sulfonated N-acetylglactosamine	440:470	sulfonated N-acetylglactosamine (SU)	440:475	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	2	67	theme	sulfonated	440:449	arg1	SU					473:474	SU	473:474	SU	473:474	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	4	68	theme	euthyroid	729:737	arg1	individuals					739:749	159 euthyroid individuals	725:749	159 euthyroid individuals	725:749	METHODS Serum samples were obtained from 25 patients with sPH, from 159 euthyroid individuals, and from 12 women during treatment with levothyroxine for sPH.
33644618	1	69	theme	severe	96:101	arg1	sPH					127:129	sPH	127:129	sPH	127:129	CONTEXT In severe primary hypothyroidism (sPH), the serum thyrotropin (TSH) levels are elevated with an increased degree of sialylation.
33644618	1	69	theme	severe	96:101	arg1	hypothyroidism					111:124	severe primary hypothyroidism	96:124	severe primary hypothyroidism (sPH)	96:130	CONTEXT In severe primary hypothyroidism (sPH), the serum thyrotropin (TSH) levels are elevated with an increased degree of sialylation.
33644618	8	70	theme	euthyroid	1484:1492	arg1	individuals					1494:1504	euthyroid individuals	1484:1504	euthyroid individuals	1484:1504	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism were less N- glycosylated, more sialylated, and less sulfonated compared with euthyroid individuals.
33644618	9	71	dep	lower	1589:1593	arg1	biopotency					1604:1613	in vitro biopotency	1595:1613	lower in vitro biopotency at the target cells	1589:1633	This glycan pattern favors a prolonged half-life in the circulation combined with lower in vitro biopotency at the target cells.
33644618	10	72	theme	FT4	1756:1758	arg1	levels					1760:1765	low FT4 levels	1752:1765	low FT4 levels	1752:1765	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33644618	6	73	theme	sPH	993:995	arg1	patients					997:1004	sPH patients	993:1004	sPH patients	993:1004	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	3	74	theme	levothyroxine	611:623	arg1	treatment					625:633	levothyroxine treatment	611:633	levothyroxine treatment	611:633	OBJECTIVE Characterize N-glycosylation and glycan composition of circulating TSH molecules and determine the effects during levothyroxine treatment in patients with sPH.
33644618	7	75	gly	sialylation	1161:1171	arg1	glycans					1196:1202	the glycans	1192:1202	the glycans	1192:1202	Levothyroxin restored sialylation and sulfonation of the glycans already at low free thyroxine (FT4) levels, while degree of N-glycosylation was not restored until the FT4 levels were normal.
33644618	2	76	theme	monosaccharides	387:401	arg1	contents					367:374	their contents	361:374	their contents	361:374	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	2	77	with	TSHtri	297:302	arg1	methods					325:331	methods	325:331	methods	325:331	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	2	77	with	TSHtri	297:302	arg1	N-glycans					311:319	3 N-glycans	309:319	3 N-glycans	309:319	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	2	77	with	TSHtri	297:302	arg1	2					291:291	2	291:291	2	291:291	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	2	78	theme	sialic	419:424	arg1	SA					432:433	SA	432:433	SA	432:433	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	2	78	theme	sialic	419:424	arg1	acid					426:429	sialic acid	419:429	sialic acid (SA)	419:434	The circulating TSH comprises 2 different TSH glycoforms: TSHdi with 2 and TSHtri with 3 N-glycans and methods have developed to determine their contents of anionic monosaccharides (AMS), that is, sialic acid (SA) and sulfonated N-acetylglactosamine (SU) residues.
33644618	10	79	theme	TSH	1793:1795	arg1	N-glycosylation					1774:1788	N-glycosylation	1774:1788	N-glycosylation of TSH	1774:1795	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33644618	1	80	theme	sialylation	209:219	arg1	degree					199:204	an increased degree	186:204	an increased degree of sialylation	186:219	CONTEXT In severe primary hypothyroidism (sPH), the serum thyrotropin (TSH) levels are elevated with an increased degree of sialylation.
33644618	0	81	theme	Primary	61:67	arg1	Hypothyroidism					69:82	Severe Primary Hypothyroidism	54:82	Severe Primary Hypothyroidism	54:82	Thyrotropin N-glycosylation and Glycan Composition in Severe Primary Hypothyroidism.
33644618	7	82	theme	thyroxine	1224:1232	arg1	levels					1240:1245	low free thyroxine (FT4) levels	1215:1245	low free thyroxine (FT4) levels	1215:1245	Levothyroxin restored sialylation and sulfonation of the glycans already at low free thyroxine (FT4) levels, while degree of N-glycosylation was not restored until the FT4 levels were normal.
33644618	10	83	theme	FT4	1824:1826	arg1	normal					1840:1845	normal	1840:1845	normal	1840:1845	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33644618	10	83	theme	FT4	1824:1826	arg1	levels					1828:1833	the FT4 levels	1820:1833	the FT4 levels	1820:1833	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33644618	1	84	theme	thyrotropin	143:153	arg1	levels					161:166	the serum thyrotropin (TSH) levels	133:166	the serum thyrotropin (TSH) levels	133:166	CONTEXT In severe primary hypothyroidism (sPH), the serum thyrotropin (TSH) levels are elevated with an increased degree of sialylation.
33644618	10	85	theme	levothyroxine	1643:1655	arg1	treatment					1657:1665	levothyroxine treatment	1643:1665	levothyroxine treatment of sPH patients	1643:1681	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33644618	10	86	gly	sialylation	1688:1698	arg1	glycans					1719:1725	glycans	1719:1725	glycans	1719:1725	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33644618	10	86	gly	sialylation	1688:1698	arg1	levels					1760:1765	low FT4 levels	1752:1765	low FT4 levels	1752:1765	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33644618	5	87	theme	SU	923:924	arg1	residues					926:933	SU residues	923:933	SU residues	923:933	Degrees of N-glycosylation and concentrations of TSHdi and TSHtri as well as their contents of AMS, SA, and SU residues were determined.
33644618	3	88	theme	TSH	564:566	arg1	molecules					568:576	circulating TSH molecules	552:576	circulating TSH molecules	552:576	OBJECTIVE Characterize N-glycosylation and glycan composition of circulating TSH molecules and determine the effects during levothyroxine treatment in patients with sPH.
33644618	7	89	theme	low	1215:1217	arg1	levels					1240:1245	low free thyroxine (FT4) levels	1215:1245	low free thyroxine (FT4) levels	1215:1245	Levothyroxin restored sialylation and sulfonation of the glycans already at low free thyroxine (FT4) levels, while degree of N-glycosylation was not restored until the FT4 levels were normal.
33644618	10	90	gly	N-glycosylation	1774:1788	arg1	TSH					1793:1795	TSH	1793:1795	TSH	1793:1795	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
33644618	6	91	theme	higher	1044:1049	arg1	degrees					1051:1057	higher degrees	1044:1057	higher degrees of sialylation	1044:1072	RESULTS The circulating TSH molecules in sPH patients had lower degrees of N-glycosylation, higher degrees of sialylation, and lower degrees of sulfonation than in euthyroid individuals.
33644618	7	92	theme	N-glycosylation	1264:1278	arg1	degree					1254:1259	degree	1254:1259	degree of N-glycosylation	1254:1278	Levothyroxin restored sialylation and sulfonation of the glycans already at low free thyroxine (FT4) levels, while degree of N-glycosylation was not restored until the FT4 levels were normal.
33644618	8	93	theme	TSH	1359:1361	arg1	molecules					1363:1371	TSH molecules	1359:1371	TSH molecules in severe primary hypothyroidism	1359:1404	CONCLUSIONS The majority of TSH molecules in severe primary hypothyroidism were less N- glycosylated, more sialylated, and less sulfonated compared with euthyroid individuals.
33644618	10	94	theme	patients	1674:1681	arg1	treatment					1657:1665	levothyroxine treatment	1643:1665	levothyroxine treatment of sPH patients	1643:1681	During levothyroxine treatment of sPH patients, the sialylation and sulfonation of glycans were restored already at low FT4 levels, while N-glycosylation of TSH was not restored until the FT4 levels were normal.
32679670	5	0	from	changes	760:766	arg1	alpha-diversity					781:795	microbial alpha-diversity	771:795	microbial alpha-diversity	771:795	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	9	1	theme	host	1591:1594	arg1	factors					1596:1602	environmental and host factors	1573:1602	environmental and host factors	1573:1602	The results further indicate that interactions between environmental and host factors can affect microbiome manipulation in the host.
32679670	1	2	theme	dietary	155:161	arg1	fiber					163:167	dietary fiber	155:167	dietary fiber	155:167	There is growing interest in studying dietary fiber to stimulate microbiome changes that might prevent or alleviate inflammatory bowel disease (IBD).
32679670	8	3	theme	specific	1358:1365	arg1	responses					1394:1402	specific immune-regulatory cytokine responses	1358:1402	specific immune-regulatory cytokine responses	1358:1402	Together, these results indicate that isomaltodextrin altered the gut microbial composition linking specific immune-regulatory cytokine responses, while the interactions among fiber, microbiota and immune response were dose dependent and largely sex specific.
32679670	0	4	theme	Fiber	70:74	arg1	Supplementation					76:90	Dietary Fiber Supplementation	62:90	Dietary Fiber Supplementation in IL-10-Deficient Mice	62:114	Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice.
32679670	0	5	from	Differences	13:23	arg1	Microbiome					36:45	the Gut Microbiome	28:45	the Gut Microbiome	28:45	Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice.
32679670	0	5	from	Differences	13:23	arg1	Response					50:57	Response	50:57	Response to Dietary Fiber Supplementation in IL-10-Deficient Mice	50:114	Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice.
32679670	7	6	from	reduction	1147:1155	arg1	alpha-diversity					1160:1174	alpha-diversity	1160:1174	alpha-diversity	1160:1174	In contrast, female mice receiving isomaltodextrin displayed a reduction in alpha-diversity and Coprococcus abundance and a high level of IL-12p70, as did the control group.
32679670	7	6	from	reduction	1147:1155	arg1	abundance					1192:1200	Coprococcus abundance	1180:1200	Coprococcus abundance	1180:1200	In contrast, female mice receiving isomaltodextrin displayed a reduction in alpha-diversity and Coprococcus abundance and a high level of IL-12p70, as did the control group.
32679670	5	7	theme	limited	854:860	arg1	reduction					862:870	limited reduction	854:870	limited reduction in the relative abundance of Coprococcus (q = 0.08)	854:922	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	8	8	theme	immune-regulatory	1367:1383	arg1	responses					1394:1402	specific immune-regulatory cytokine responses	1358:1402	specific immune-regulatory cytokine responses	1358:1402	Together, these results indicate that isomaltodextrin altered the gut microbial composition linking specific immune-regulatory cytokine responses, while the interactions among fiber, microbiota and immune response were dose dependent and largely sex specific.
32679670	0	9	theme	IL-10-Deficient	95:109	arg1	Mice					111:114	IL-10-Deficient Mice	95:114	IL-10-Deficient Mice	95:114	Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice.
32679670	3	10	from	effects	400:406	arg1	IBD					449:451	IBD	449:451	IBD	449:451	This study examined whether the effects of isomaltodextrin on gut microbiota and IBD were dependent on dose or host sex, using an Interleukin (IL)-10 deficient murine colitis model.
32679670	3	10	from	effects	400:406	arg1	microbiota					434:443	gut microbiota	430:443	gut microbiota	430:443	This study examined whether the effects of isomaltodextrin on gut microbiota and IBD were dependent on dose or host sex, using an Interleukin (IL)-10 deficient murine colitis model.
32679670	7	11	dep	did	1235:1237	arg1	as					1232:1233	as	1232:1233	as	1232:1233	In contrast, female mice receiving isomaltodextrin displayed a reduction in alpha-diversity and Coprococcus abundance and a high level of IL-12p70, as did the control group.
32679670	2	12	theme	fiber	284:288	arg1	effects					290:296	dietary fiber effects	276:296	dietary fiber effects	276:296	However, dietary fiber effects have shown varying degrees of efficacy, for reasons that are unclear.
32679670	3	13	theme	deficient	518:526	arg1	model					543:547	an Interleukin (IL)-10 deficient murine colitis model	495:547	an Interleukin (IL)-10 deficient murine colitis model	495:547	This study examined whether the effects of isomaltodextrin on gut microbiota and IBD were dependent on dose or host sex, using an Interleukin (IL)-10 deficient murine colitis model.
32679670	8	14	theme	immune	1456:1461	arg1	response					1463:1470	immune response	1456:1470	immune response	1456:1470	Together, these results indicate that isomaltodextrin altered the gut microbial composition linking specific immune-regulatory cytokine responses, while the interactions among fiber, microbiota and immune response were dose dependent and largely sex specific.
32679670	2	15	theme	dietary	276:282	arg1	effects					290:296	dietary fiber effects	276:296	dietary fiber effects	276:296	However, dietary fiber effects have shown varying degrees of efficacy, for reasons that are unclear.
32679670	3	16	theme	IL	511:512	arg1	model					543:547	an Interleukin (IL)-10 deficient murine colitis model	495:547	an Interleukin (IL)-10 deficient murine colitis model	495:547	This study examined whether the effects of isomaltodextrin on gut microbiota and IBD were dependent on dose or host sex, using an Interleukin (IL)-10 deficient murine colitis model.
32679670	9	17	theme	microbiome	1615:1624	arg1	manipulation					1626:1637	microbiome manipulation	1615:1637	microbiome manipulation	1615:1637	The results further indicate that interactions between environmental and host factors can affect microbiome manipulation in the host.
32679670	4	18	theme	=	695:695	arg1	p					693:693	p = 0.04	693:700	p = 0.04	693:700	After 12 weeks, colonic IL-12p70 was depressed in male mice receiving high-dose isomaltodextrin supplementation compared to the control group (p = 0.04).
32679670	4	18	theme	=	695:695	arg1	group					686:690	the control group	674:690	the control group (p = 0.04)	674:701	After 12 weeks, colonic IL-12p70 was depressed in male mice receiving high-dose isomaltodextrin supplementation compared to the control group (p = 0.04).
32679670	3	19	dep	dose	471:474	arg1	sex					484:486	sex	484:486	sex	484:486	This study examined whether the effects of isomaltodextrin on gut microbiota and IBD were dependent on dose or host sex, using an Interleukin (IL)-10 deficient murine colitis model.
32679670	4	20	theme	high-dose	620:628	arg1	supplementation					646:660	high-dose isomaltodextrin supplementation	620:660	high-dose isomaltodextrin supplementation compared to the control group (p = 0.04)	620:701	After 12 weeks, colonic IL-12p70 was depressed in male mice receiving high-dose isomaltodextrin supplementation compared to the control group (p = 0.04).
32679670	6	21	theme	IL-12p70	1026:1033	arg1	levels					1035:1040	IL-12p70 levels	1026:1040	IL-12p70 levels in the male group	1026:1058	These microbial compositional changes were negatively associated with IL-12p70 levels in the male group (rs ≤ -0.51, q ≤ 0.08).
32679670	7	22	theme	IL-12p70	1222:1229	arg1	reduction					1147:1155	a reduction	1145:1155	a reduction in alpha-diversity and Coprococcus abundance	1145:1200	In contrast, female mice receiving isomaltodextrin displayed a reduction in alpha-diversity and Coprococcus abundance and a high level of IL-12p70, as did the control group.
32679670	7	22	theme	IL-12p70	1222:1229	arg1	level					1213:1217	a high level	1206:1217	a high level of IL-12p70	1206:1229	In contrast, female mice receiving isomaltodextrin displayed a reduction in alpha-diversity and Coprococcus abundance and a high level of IL-12p70, as did the control group.
32679670	3	23	theme	Interleukin	498:508	arg1	IL					511:512	Interleukin (IL)-10	498:516	an Interleukin (IL)-10 deficient murine colitis model	495:547	This study examined whether the effects of isomaltodextrin on gut microbiota and IBD were dependent on dose or host sex, using an Interleukin (IL)-10 deficient murine colitis model.
32679670	3	24	theme	gut	430:432	arg1	microbiota					434:443	gut microbiota	430:443	gut microbiota	430:443	This study examined whether the effects of isomaltodextrin on gut microbiota and IBD were dependent on dose or host sex, using an Interleukin (IL)-10 deficient murine colitis model.
32679670	2	25	theme	varying	309:315	arg1	degrees					317:323	varying degrees	309:323	varying degrees of efficacy	309:335	However, dietary fiber effects have shown varying degrees of efficacy, for reasons that are unclear.
32679670	1	26	theme	microbiome	182:191	arg1	changes					193:199	microbiome changes	182:199	microbiome changes that might prevent or alleviate inflammatory bowel disease (IBD)	182:264	There is growing interest in studying dietary fiber to stimulate microbiome changes that might prevent or alleviate inflammatory bowel disease (IBD).
32679670	0	27	theme	Sex-Specific	0:11	arg1	Differences					13:23	Sex-Specific Differences	0:23	Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice.	0:115	Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice.
32679670	5	28	from	reduction	862:870	arg1	abundance					888:896	the relative abundance	875:896	the relative abundance of Coprococcus (q = 0.08)	875:922	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	3	29	theme	murine	528:533	arg1	model					543:547	an Interleukin (IL)-10 deficient murine colitis model	495:547	an Interleukin (IL)-10 deficient murine colitis model	495:547	This study examined whether the effects of isomaltodextrin on gut microbiota and IBD were dependent on dose or host sex, using an Interleukin (IL)-10 deficient murine colitis model.
32679670	3	30	theme	isomaltodextrin	411:425	arg1	dependent					458:466	dependent	458:466	dependent	458:466	This study examined whether the effects of isomaltodextrin on gut microbiota and IBD were dependent on dose or host sex, using an Interleukin (IL)-10 deficient murine colitis model.
32679670	3	30	theme	isomaltodextrin	411:425	arg1	effects					400:406	the effects	396:406	the effects of isomaltodextrin on gut microbiota and IBD	396:451	This study examined whether the effects of isomaltodextrin on gut microbiota and IBD were dependent on dose or host sex, using an Interleukin (IL)-10 deficient murine colitis model.
32679670	5	31	theme	microbial	771:779	arg1	alpha-diversity					781:795	microbial alpha-diversity	771:795	microbial alpha-diversity	771:795	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	5	32	theme	Coprococcus	901:911	arg1	abundance					888:896	the relative abundance	875:896	the relative abundance of Coprococcus (q = 0.08)	875:922	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	0	33	from	Supplementation	76:90	arg1	Mice					111:114	IL-10-Deficient Mice	95:114	IL-10-Deficient Mice	95:114	Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice.
32679670	5	34	theme	enhanced	808:815	arg1	richness					817:824	richness	817:824	richness	817:824	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	5	34	theme	enhanced	808:815	arg1	p					840:840	p = 0.01	840:847	p = 0.01	840:847	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	5	35	theme	high-dose	724:732	arg1	isomaltodextrin					734:748	high-dose isomaltodextrin	724:748	high-dose isomaltodextrin	724:748	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	7	36	theme	high	1208:1211	arg1	level					1213:1217	a high level	1206:1217	a high level of IL-12p70	1206:1229	In contrast, female mice receiving isomaltodextrin displayed a reduction in alpha-diversity and Coprococcus abundance and a high level of IL-12p70, as did the control group.
32679670	5	37	theme	control	941:947	arg1	group					949:953	the control group	937:953	the control group	937:953	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	5	38	theme	=	842:842	arg1	richness					817:824	richness	817:824	richness	817:824	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	5	38	theme	=	842:842	arg1	p					840:840	p = 0.01	840:847	p = 0.01	840:847	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	6	39	theme	compositional	972:984	arg1	changes					986:992	These microbial compositional changes	956:992	These microbial compositional changes	956:992	These microbial compositional changes were negatively associated with IL-12p70 levels in the male group (rs ≤ -0.51, q ≤ 0.08).
32679670	0	40	theme	Gut	32:34	arg1	Microbiome					36:45	the Gut Microbiome	28:45	the Gut Microbiome	28:45	Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice.
32679670	4	41	theme	colonic	566:572	arg1	IL-12p70					574:581	colonic IL-12p70	566:581	colonic IL-12p70	566:581	After 12 weeks, colonic IL-12p70 was depressed in male mice receiving high-dose isomaltodextrin supplementation compared to the control group (p = 0.04).
32679670	5	42	from	richness	817:824	arg1	abundance					888:896	the relative abundance	875:896	the relative abundance of Coprococcus (q = 0.08)	875:922	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	6	43	theme	microbial	962:970	arg1	changes					986:992	These microbial compositional changes	956:992	These microbial compositional changes	956:992	These microbial compositional changes were negatively associated with IL-12p70 levels in the male group (rs ≤ -0.51, q ≤ 0.08).
32679670	7	44	theme	female	1097:1102	arg1	mice					1104:1107	female mice	1097:1107	female mice receiving isomaltodextrin	1097:1133	In contrast, female mice receiving isomaltodextrin displayed a reduction in alpha-diversity and Coprococcus abundance and a high level of IL-12p70, as did the control group.
32679670	8	45	theme	cytokine	1385:1392	arg1	responses					1394:1402	specific immune-regulatory cytokine responses	1358:1402	specific immune-regulatory cytokine responses	1358:1402	Together, these results indicate that isomaltodextrin altered the gut microbial composition linking specific immune-regulatory cytokine responses, while the interactions among fiber, microbiota and immune response were dose dependent and largely sex specific.
32679670	3	46	theme	colitis	535:541	arg1	model					543:547	an Interleukin (IL)-10 deficient murine colitis model	495:547	an Interleukin (IL)-10 deficient murine colitis model	495:547	This study examined whether the effects of isomaltodextrin on gut microbiota and IBD were dependent on dose or host sex, using an Interleukin (IL)-10 deficient murine colitis model.
32679670	7	47	from	level	1213:1217	arg1	alpha-diversity					1160:1174	alpha-diversity	1160:1174	alpha-diversity	1160:1174	In contrast, female mice receiving isomaltodextrin displayed a reduction in alpha-diversity and Coprococcus abundance and a high level of IL-12p70, as did the control group.
32679670	7	47	from	level	1213:1217	arg1	abundance					1192:1200	Coprococcus abundance	1180:1200	Coprococcus abundance	1180:1200	In contrast, female mice receiving isomaltodextrin displayed a reduction in alpha-diversity and Coprococcus abundance and a high level of IL-12p70, as did the control group.
32679670	4	48	theme	control	678:684	arg1	p					693:693	p = 0.04	693:700	p = 0.04	693:700	After 12 weeks, colonic IL-12p70 was depressed in male mice receiving high-dose isomaltodextrin supplementation compared to the control group (p = 0.04).
32679670	4	48	theme	control	678:684	arg1	group					686:690	the control group	674:690	the control group (p = 0.04)	674:701	After 12 weeks, colonic IL-12p70 was depressed in male mice receiving high-dose isomaltodextrin supplementation compared to the control group (p = 0.04).
32679670	7	49	theme	Coprococcus	1180:1190	arg1	abundance					1192:1200	Coprococcus abundance	1180:1200	Coprococcus abundance	1180:1200	In contrast, female mice receiving isomaltodextrin displayed a reduction in alpha-diversity and Coprococcus abundance and a high level of IL-12p70, as did the control group.
32679670	9	50	theme	environmental	1573:1585	arg1	factors					1596:1602	environmental and host factors	1573:1602	environmental and host factors	1573:1602	The results further indicate that interactions between environmental and host factors can affect microbiome manipulation in the host.
32679670	2	51	theme	efficacy	328:335	arg1	degrees					317:323	varying degrees	309:323	varying degrees of efficacy	309:335	However, dietary fiber effects have shown varying degrees of efficacy, for reasons that are unclear.
32679670	6	52	dep	associated	1010:1019	arg1	rs					1061:1062	rs	1061:1062	rs	1061:1062	These microbial compositional changes were negatively associated with IL-12p70 levels in the male group (rs ≤ -0.51, q ≤ 0.08).
32679670	8	53	theme	microbial	1328:1336	arg1	composition					1338:1348	the gut microbial composition	1320:1348	the gut microbial composition linking specific immune-regulatory cytokine responses	1320:1402	Together, these results indicate that isomaltodextrin altered the gut microbial composition linking specific immune-regulatory cytokine responses, while the interactions among fiber, microbiota and immune response were dose dependent and largely sex specific.
32679670	1	54	theme	growing	126:132	arg1	interest					134:141	growing interest	126:141	growing interest in studying dietary fiber to stimulate microbiome changes that might prevent or alleviate inflammatory bowel disease (IBD)	126:264	There is growing interest in studying dietary fiber to stimulate microbiome changes that might prevent or alleviate inflammatory bowel disease (IBD).
32679670	8	55	dep	dependent	1482:1490	arg1	specific					1508:1515	specific	1508:1515	specific	1508:1515	Together, these results indicate that isomaltodextrin altered the gut microbial composition linking specific immune-regulatory cytokine responses, while the interactions among fiber, microbiota and immune response were dose dependent and largely sex specific.
32679670	8	55	dep	dependent	1482:1490	arg1	dependent					1482:1490	dependent	1482:1490	dependent	1482:1490	Together, these results indicate that isomaltodextrin altered the gut microbial composition linking specific immune-regulatory cytokine responses, while the interactions among fiber, microbiota and immune response were dose dependent and largely sex specific.
32679670	8	55	dep	dependent	1482:1490	arg1	interactions					1415:1426	the interactions	1411:1426	the interactions among fiber, microbiota and immune response	1411:1470	Together, these results indicate that isomaltodextrin altered the gut microbial composition linking specific immune-regulatory cytokine responses, while the interactions among fiber, microbiota and immune response were dose dependent and largely sex specific.
32679670	8	56	theme	gut	1324:1326	arg1	composition					1338:1348	the gut microbial composition	1320:1348	the gut microbial composition linking specific immune-regulatory cytokine responses	1320:1402	Together, these results indicate that isomaltodextrin altered the gut microbial composition linking specific immune-regulatory cytokine responses, while the interactions among fiber, microbiota and immune response were dose dependent and largely sex specific.
32679670	5	57	theme	relative	879:886	arg1	abundance					888:896	the relative abundance	875:896	the relative abundance of Coprococcus (q = 0.08)	875:922	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	1	58	theme	inflammatory	233:244	arg1	IBD					261:263	IBD	261:263	IBD	261:263	There is growing interest in studying dietary fiber to stimulate microbiome changes that might prevent or alleviate inflammatory bowel disease (IBD).
32679670	1	58	theme	inflammatory	233:244	arg1	disease					252:258	inflammatory bowel disease	233:258	inflammatory bowel disease (IBD)	233:264	There is growing interest in studying dietary fiber to stimulate microbiome changes that might prevent or alleviate inflammatory bowel disease (IBD).
32679670	0	59	theme	Dietary	62:68	arg1	Supplementation					76:90	Dietary Fiber Supplementation	62:90	Dietary Fiber Supplementation in IL-10-Deficient Mice	62:114	Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice.
32679670	7	60	theme	control	1243:1249	arg1	group					1251:1255	the control group	1239:1255	the control group	1239:1255	In contrast, female mice receiving isomaltodextrin displayed a reduction in alpha-diversity and Coprococcus abundance and a high level of IL-12p70, as did the control group.
32679670	6	61	from	levels	1035:1040	arg1	group					1054:1058	the male group	1045:1058	the male group	1045:1058	These microbial compositional changes were negatively associated with IL-12p70 levels in the male group (rs ≤ -0.51, q ≤ 0.08).
32679670	6	62	theme	male	1049:1052	arg1	group					1054:1058	the male group	1045:1058	the male group	1045:1058	These microbial compositional changes were negatively associated with IL-12p70 levels in the male group (rs ≤ -0.51, q ≤ 0.08).
32679670	4	63	theme	male	600:603	arg1	mice					605:608	male mice	600:608	male mice receiving high-dose isomaltodextrin supplementation compared to the control group (p = 0.04)	600:701	After 12 weeks, colonic IL-12p70 was depressed in male mice receiving high-dose isomaltodextrin supplementation compared to the control group (p = 0.04).
32679670	1	64	theme	bowel	246:250	arg1	IBD					261:263	IBD	261:263	IBD	261:263	There is growing interest in studying dietary fiber to stimulate microbiome changes that might prevent or alleviate inflammatory bowel disease (IBD).
32679670	1	64	theme	bowel	246:250	arg1	disease					252:258	inflammatory bowel disease	233:258	inflammatory bowel disease (IBD)	233:264	There is growing interest in studying dietary fiber to stimulate microbiome changes that might prevent or alleviate inflammatory bowel disease (IBD).
32679670	5	65	theme	Male	704:707	arg1	mice					709:712	Male mice	704:712	Male mice receiving high-dose isomaltodextrin	704:748	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	5	66	theme	=	916:916	arg1	Coprococcus					901:911	Coprococcus	901:911	Coprococcus (q = 0.08)	901:922	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	5	66	theme	=	916:916	arg1	q					914:914	q = 0.08	914:921	q = 0.08	914:921	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	6	67	dep	rs	1061:1062	arg1	q					1073:1073	q	1073:1073	q	1073:1073	These microbial compositional changes were negatively associated with IL-12p70 levels in the male group (rs ≤ -0.51, q ≤ 0.08).
32679670	6	67	dep	rs	1061:1062	arg1	-0.51					1066:1070	-0.51	1066:1070	-0.51	1066:1070	These microbial compositional changes were negatively associated with IL-12p70 levels in the male group (rs ≤ -0.51, q ≤ 0.08).
32679670	6	67	dep	rs	1061:1062	arg1	0.08					1077:1080	0.08	1077:1080	0.08	1077:1080	These microbial compositional changes were negatively associated with IL-12p70 levels in the male group (rs ≤ -0.51, q ≤ 0.08).
32679670	5	68	from	evenness	830:837	arg1	abundance					888:896	the relative abundance	875:896	the relative abundance of Coprococcus (q = 0.08)	875:922	Male mice receiving high-dose isomaltodextrin exhibited changes in microbial alpha-diversity, including enhanced richness and evenness (p = 0.01) and limited reduction in the relative abundance of Coprococcus (q = 0.08), compared to the control group.
32679670	4	69	theme	isomaltodextrin	630:644	arg1	supplementation					646:660	high-dose isomaltodextrin supplementation	620:660	high-dose isomaltodextrin supplementation compared to the control group (p = 0.04)	620:701	After 12 weeks, colonic IL-12p70 was depressed in male mice receiving high-dose isomaltodextrin supplementation compared to the control group (p = 0.04).
34161074	0	0	from	Hardening	7:15	arg1	Gels					47:50	Highly Acetylated Chitosan Gels	20:50	Highly Acetylated Chitosan Gels	20:50	Strain Hardening in Highly Acetylated Chitosan Gels.
34161074	7	1	theme	nonlinear	1133:1141	arg1	elasticity					1143:1152	nonlinear elasticity	1133:1152	nonlinear elasticity	1133:1152	Furthermore, we identified a relationship between critical strain marking nonlinear elasticity and the network connectivity, being similar to that found for the cytoskeletal collagen matrix, indicating the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics.
34161074	4	2	theme	temporary	616:624	arg1	nodes					626:630	temporary nodes	616:630	temporary nodes arising from the entangling of chains between stable cross-links	616:695	While varying the chitosan physical-chemical composition and network connectivity, we provide evidence that temporary nodes arising from the entangling of chains between stable cross-links are at the root of nonlinear elasticity.
34161074	4	3	theme	physical-chemical	535:551	arg1	composition					553:563	the chitosan physical-chemical composition	522:563	the chitosan physical-chemical composition	522:563	While varying the chitosan physical-chemical composition and network connectivity, we provide evidence that temporary nodes arising from the entangling of chains between stable cross-links are at the root of nonlinear elasticity.
34161074	1	4	theme	Strain	53:58	arg1	hardening					60:68	Strain hardening	53:68	Strain hardening	53:68	Strain hardening has recently emerged as a near-universal response of biological tissues to mechanical stimulation as well as a powerful regulator of cell fate.
34161074	7	5	theme	potential	1265:1273	arg1	use					1275:1277	the potential use	1261:1277	the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics	1261:1366	Furthermore, we identified a relationship between critical strain marking nonlinear elasticity and the network connectivity, being similar to that found for the cytoskeletal collagen matrix, indicating the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics.
34161074	7	6	theme	critical	1109:1116	arg1	strain					1118:1123	critical strain	1109:1123	critical strain marking nonlinear elasticity and the network connectivity	1109:1181	Furthermore, we identified a relationship between critical strain marking nonlinear elasticity and the network connectivity, being similar to that found for the cytoskeletal collagen matrix, indicating the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics.
34161074	5	7	theme	entanglement	867:878	arg1	larger					799:804	larger	799:804	larger	799:804	The contour length (Lc) of the said chains revealed that the larger the chain length between the cross-links, the greater is the entanglement over disentanglement upon network stretching.
34161074	5	7	theme	entanglement	867:878	arg1	disentanglement					885:899	the entanglement over disentanglement	863:899	the entanglement over disentanglement upon network stretching	863:923	The contour length (Lc) of the said chains revealed that the larger the chain length between the cross-links, the greater is the entanglement over disentanglement upon network stretching.
34161074	6	8	theme	hardening	1042:1050	arg1	onset					1026:1030	the onset	1022:1030	the onset of strain hardening	1022:1050	To this end, we calculated that the minimum number of Khun's segments in Lc that contributes to the onset of strain hardening is 15.
34161074	3	9	theme	strain	455:460	arg1	hardening					462:470	strain hardening	455:470	strain hardening	455:470	Here, we show that covalent networks built from highly acetylated chitosans exhibit strain hardening at physiological pH and osmolarity.
34161074	5	10	theme	said	769:772	arg1	chains					774:779	the said chains	765:779	the said chains	765:779	The contour length (Lc) of the said chains revealed that the larger the chain length between the cross-links, the greater is the entanglement over disentanglement upon network stretching.
34161074	6	11	from	segments	987:994	arg1	Lc					999:1000	Lc	999:1000	Lc	999:1000	To this end, we calculated that the minimum number of Khun's segments in Lc that contributes to the onset of strain hardening is 15.
34161074	5	12	theme	over	880:883	arg1	larger					799:804	larger	799:804	larger	799:804	The contour length (Lc) of the said chains revealed that the larger the chain length between the cross-links, the greater is the entanglement over disentanglement upon network stretching.
34161074	5	12	theme	over	880:883	arg1	disentanglement					885:899	the entanglement over disentanglement	863:899	the entanglement over disentanglement upon network stretching	863:923	The contour length (Lc) of the said chains revealed that the larger the chain length between the cross-links, the greater is the entanglement over disentanglement upon network stretching.
34161074	3	13	theme	covalent	390:397	arg1	networks					399:406	covalent networks	390:406	covalent networks built from highly acetylated chitosans	390:445	Here, we show that covalent networks built from highly acetylated chitosans exhibit strain hardening at physiological pH and osmolarity.
34161074	5	14	dep	larger	799:804	arg1	length					816:821	the chain length	806:821	the larger the chain length between the cross-links	795:845	The contour length (Lc) of the said chains revealed that the larger the chain length between the cross-links, the greater is the entanglement over disentanglement upon network stretching.
34161074	7	15	theme	cytoskeletal	1220:1231	arg1	matrix					1242:1247	the cytoskeletal collagen matrix	1216:1247	the cytoskeletal collagen matrix	1216:1247	Furthermore, we identified a relationship between critical strain marking nonlinear elasticity and the network connectivity, being similar to that found for the cytoskeletal collagen matrix, indicating the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics.
34161074	7	16	theme	chitosans	1316:1324	arg1	use					1275:1277	the potential use	1261:1277	the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics	1261:1366	Furthermore, we identified a relationship between critical strain marking nonlinear elasticity and the network connectivity, being similar to that found for the cytoskeletal collagen matrix, indicating the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics.
34161074	1	17	theme	powerful	181:188	arg1	regulator					190:198	a powerful regulator	179:198	a powerful regulator of cell fate	179:211	Strain hardening has recently emerged as a near-universal response of biological tissues to mechanical stimulation as well as a powerful regulator of cell fate.
34161074	7	18	theme	network	1162:1168	arg1	connectivity					1170:1181	the network connectivity	1158:1181	the network connectivity	1158:1181	Furthermore, we identified a relationship between critical strain marking nonlinear elasticity and the network connectivity, being similar to that found for the cytoskeletal collagen matrix, indicating the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics.
34161074	5	19	theme	contour	742:748	arg1	length					750:755	The contour length	738:755	The contour length (Lc) of the said chains	738:779	The contour length (Lc) of the said chains revealed that the larger the chain length between the cross-links, the greater is the entanglement over disentanglement upon network stretching.
34161074	5	19	theme	contour	742:748	arg1	Lc					758:759	Lc	758:759	Lc	758:759	The contour length (Lc) of the said chains revealed that the larger the chain length between the cross-links, the greater is the entanglement over disentanglement upon network stretching.
34161074	2	20	theme	bioinspired	306:316	arg1	materials					318:326	bioinspired materials	306:326	bioinspired materials that mimic extracellular matrix mechanics	306:368	Understanding the mechanistic basis for this nonlinear elasticity is crucial for developing bioinspired materials that mimic extracellular matrix mechanics.
34161074	7	21	dep	chitosans	1316:1324	arg1	pH-soluble					1304:1313	pH-soluble	1304:1313	pH-soluble	1304:1313	Furthermore, we identified a relationship between critical strain marking nonlinear elasticity and the network connectivity, being similar to that found for the cytoskeletal collagen matrix, indicating the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics.
34161074	4	22	theme	stable	678:683	arg1	cross-links					685:695	stable cross-links	678:695	stable cross-links	678:695	While varying the chitosan physical-chemical composition and network connectivity, we provide evidence that temporary nodes arising from the entangling of chains between stable cross-links are at the root of nonlinear elasticity.
34161074	1	23	theme	near-universal	96:109	arg1	response					111:118	a near-universal response	94:118	a near-universal response of biological tissues to mechanical stimulation	94:166	Strain hardening has recently emerged as a near-universal response of biological tissues to mechanical stimulation as well as a powerful regulator of cell fate.
34161074	5	24	theme	network	906:912	arg1	stretching					914:923	network stretching	906:923	network stretching	906:923	The contour length (Lc) of the said chains revealed that the larger the chain length between the cross-links, the greater is the entanglement over disentanglement upon network stretching.
34161074	0	25	theme	Chitosan	38:45	arg1	Gels					47:50	Highly Acetylated Chitosan Gels	20:50	Highly Acetylated Chitosan Gels	20:50	Strain Hardening in Highly Acetylated Chitosan Gels.
34161074	7	26	theme	semiflexible	1282:1293	arg1	chitosans					1316:1324	semiflexible (neutral pH-soluble) chitosans	1282:1324	semiflexible (neutral pH-soluble) chitosans	1282:1324	Furthermore, we identified a relationship between critical strain marking nonlinear elasticity and the network connectivity, being similar to that found for the cytoskeletal collagen matrix, indicating the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics.
34161074	6	27	theme	strain	1035:1040	arg1	hardening					1042:1050	strain hardening	1035:1050	strain hardening	1035:1050	To this end, we calculated that the minimum number of Khun's segments in Lc that contributes to the onset of strain hardening is 15.
34161074	2	28	theme	mechanistic	232:242	arg1	basis					244:248	the mechanistic basis	228:248	the mechanistic basis for this nonlinear elasticity	228:278	Understanding the mechanistic basis for this nonlinear elasticity is crucial for developing bioinspired materials that mimic extracellular matrix mechanics.
34161074	1	29	theme	cell	203:206	arg1	fate					208:211	cell fate	203:211	cell fate	203:211	Strain hardening has recently emerged as a near-universal response of biological tissues to mechanical stimulation as well as a powerful regulator of cell fate.
34161074	0	30	theme	Acetylated	27:36	arg1	Gels					47:50	Highly Acetylated Chitosan Gels	20:50	Highly Acetylated Chitosan Gels	20:50	Strain Hardening in Highly Acetylated Chitosan Gels.
34161074	4	31	theme	network	569:575	arg1	connectivity					577:588	network connectivity	569:588	network connectivity	569:588	While varying the chitosan physical-chemical composition and network connectivity, we provide evidence that temporary nodes arising from the entangling of chains between stable cross-links are at the root of nonlinear elasticity.
34161074	3	32	theme	acetylated	426:435	arg1	chitosans					437:445	highly acetylated chitosans	419:445	highly acetylated chitosans	419:445	Here, we show that covalent networks built from highly acetylated chitosans exhibit strain hardening at physiological pH and osmolarity.
34161074	3	33	theme	physiological	475:487	arg1	pH					489:490	physiological pH	475:490	physiological pH	475:490	Here, we show that covalent networks built from highly acetylated chitosans exhibit strain hardening at physiological pH and osmolarity.
34161074	5	34	theme	chain	810:814	arg1	length					816:821	the chain length	806:821	the larger the chain length between the cross-links	795:845	The contour length (Lc) of the said chains revealed that the larger the chain length between the cross-links, the greater is the entanglement over disentanglement upon network stretching.
34161074	6	35	theme	minimum	962:968	arg1	15					1055:1056	15	1055:1056	15	1055:1056	To this end, we calculated that the minimum number of Khun's segments in Lc that contributes to the onset of strain hardening is 15.
34161074	6	35	theme	minimum	962:968	arg1	number					970:975	the minimum number	958:975	the minimum number of Khun's segments in Lc that contributes to the onset of strain hardening	958:1050	To this end, we calculated that the minimum number of Khun's segments in Lc that contributes to the onset of strain hardening is 15.
34161074	7	36	dep	similar	1190:1196	arg1	indicating					1250:1259	indicating	1250:1259	indicating the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics	1250:1366	Furthermore, we identified a relationship between critical strain marking nonlinear elasticity and the network connectivity, being similar to that found for the cytoskeletal collagen matrix, indicating the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics.
34161074	2	37	theme	matrix	353:358	arg1	mechanics					360:368	extracellular matrix mechanics	339:368	extracellular matrix mechanics	339:368	Understanding the mechanistic basis for this nonlinear elasticity is crucial for developing bioinspired materials that mimic extracellular matrix mechanics.
34161074	2	38	theme	nonlinear	259:267	arg1	elasticity					269:278	this nonlinear elasticity	254:278	this nonlinear elasticity	254:278	Understanding the mechanistic basis for this nonlinear elasticity is crucial for developing bioinspired materials that mimic extracellular matrix mechanics.
34161074	4	39	theme	nonlinear	716:724	arg1	elasticity					726:735	nonlinear elasticity	716:735	nonlinear elasticity	716:735	While varying the chitosan physical-chemical composition and network connectivity, we provide evidence that temporary nodes arising from the entangling of chains between stable cross-links are at the root of nonlinear elasticity.
34161074	1	40	theme	biological	123:132	arg1	tissues					134:140	biological tissues	123:140	biological tissues	123:140	Strain hardening has recently emerged as a near-universal response of biological tissues to mechanical stimulation as well as a powerful regulator of cell fate.
34161074	1	41	theme	tissues	134:140	arg1	response					111:118	a near-universal response	94:118	a near-universal response of biological tissues to mechanical stimulation	94:166	Strain hardening has recently emerged as a near-universal response of biological tissues to mechanical stimulation as well as a powerful regulator of cell fate.
34161074	2	42	theme	extracellular	339:351	arg1	mechanics					360:368	extracellular matrix mechanics	339:368	extracellular matrix mechanics	339:368	Understanding the mechanistic basis for this nonlinear elasticity is crucial for developing bioinspired materials that mimic extracellular matrix mechanics.
34161074	5	43	theme	chains	774:779	arg1	length					750:755	The contour length	738:755	The contour length (Lc) of the said chains	738:779	The contour length (Lc) of the said chains revealed that the larger the chain length between the cross-links, the greater is the entanglement over disentanglement upon network stretching.
34161074	5	43	theme	chains	774:779	arg1	Lc					758:759	Lc	758:759	Lc	758:759	The contour length (Lc) of the said chains revealed that the larger the chain length between the cross-links, the greater is the entanglement over disentanglement upon network stretching.
34161074	1	44	theme	fate	208:211	arg1	regulator					190:198	a powerful regulator	179:198	a powerful regulator of cell fate	179:211	Strain hardening has recently emerged as a near-universal response of biological tissues to mechanical stimulation as well as a powerful regulator of cell fate.
34161074	7	45	dep	matrix	1354:1359	arg1	mimics					1361:1366	mimics	1361:1366	mimics	1361:1366	Furthermore, we identified a relationship between critical strain marking nonlinear elasticity and the network connectivity, being similar to that found for the cytoskeletal collagen matrix, indicating the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics.
34161074	4	46	theme	elasticity	726:735	arg1	root					708:711	the root	704:711	the root of nonlinear elasticity	704:735	While varying the chitosan physical-chemical composition and network connectivity, we provide evidence that temporary nodes arising from the entangling of chains between stable cross-links are at the root of nonlinear elasticity.
34161074	7	47	theme	extracellular	1340:1352	arg1	matrix					1354:1359	extracellular matrix mimics	1340:1366	extracellular matrix mimics	1340:1366	Furthermore, we identified a relationship between critical strain marking nonlinear elasticity and the network connectivity, being similar to that found for the cytoskeletal collagen matrix, indicating the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics.
34161074	4	48	theme	chains	663:668	arg1	entangling					649:658	the entangling	645:658	the entangling of chains between stable cross-links	645:695	While varying the chitosan physical-chemical composition and network connectivity, we provide evidence that temporary nodes arising from the entangling of chains between stable cross-links are at the root of nonlinear elasticity.
34161074	7	49	theme	collagen	1233:1240	arg1	matrix					1242:1247	the cytoskeletal collagen matrix	1216:1247	the cytoskeletal collagen matrix	1216:1247	Furthermore, we identified a relationship between critical strain marking nonlinear elasticity and the network connectivity, being similar to that found for the cytoskeletal collagen matrix, indicating the potential use of semiflexible (neutral pH-soluble) chitosans in assembling extracellular matrix mimics.
34161074	4	50	theme	chitosan	526:533	arg1	composition					553:563	the chitosan physical-chemical composition	522:563	the chitosan physical-chemical composition	522:563	While varying the chitosan physical-chemical composition and network connectivity, we provide evidence that temporary nodes arising from the entangling of chains between stable cross-links are at the root of nonlinear elasticity.
34161074	1	51	theme	mechanical	145:154	arg1	stimulation					156:166	mechanical stimulation	145:166	mechanical stimulation	145:166	Strain hardening has recently emerged as a near-universal response of biological tissues to mechanical stimulation as well as a powerful regulator of cell fate.
32562257	3	0	theme	oil	622:624	arg1	growth					553:558	the plant growth	543:558	the plant growth	543:558	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	0	theme	oil	622:624	arg1	percentage					626:635	oil percentage	622:635	oil percentage	622:635	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	4	1	theme	total	1027:1031	arg1	proteins					980:987	total soluble proteins	966:987	total soluble proteins	966:987	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	1	theme	total	1027:1031	arg1	phenolics					1033:1041	total phenolics	1027:1041	total phenolics	1027:1041	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	2	theme	shoot	938:942	arg1	contents					1104:1111	shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents	922:1111	shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents	922:1111	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	3	theme	dismutase	1163:1171	arg1	enzymes					1200:1206	catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes	1136:1206	catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes	1136:1234	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	6	4	theme	sunflower	1524:1532	arg1	growth					1461:1466	plant growth	1455:1466	plant growth	1455:1466	Overall, foliar-applied trehalose improved plant growth, oxidative defense system, yield and oil composition of sunflower under drought stress conditions.
32562257	6	4	theme	sunflower	1524:1532	arg1	yield					1495:1499	yield	1495:1499	yield	1495:1499	Overall, foliar-applied trehalose improved plant growth, oxidative defense system, yield and oil composition of sunflower under drought stress conditions.
32562257	6	4	theme	sunflower	1524:1532	arg1	composition					1509:1519	oil composition	1505:1519	oil composition	1505:1519	Overall, foliar-applied trehalose improved plant growth, oxidative defense system, yield and oil composition of sunflower under drought stress conditions.
32562257	6	4	theme	sunflower	1524:1532	arg1	system					1487:1492	oxidative defense system	1469:1492	oxidative defense system	1469:1492	Overall, foliar-applied trehalose improved plant growth, oxidative defense system, yield and oil composition of sunflower under drought stress conditions.
32562257	5	5	theme	plant	1297:1301	arg1	growth					1303:1308	plant growth	1297:1308	plant growth	1297:1308	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	1	6	theme	stress	376:381	arg1	conditions					383:392	control and drought stress conditions	356:392	control and drought stress conditions	356:392	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	4	7	theme	catalase	1136:1143	arg1	enzymes					1200:1206	catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes	1136:1206	catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes	1136:1234	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	8	theme	dry	953:955	arg1	proteins					980:987	total soluble proteins	966:987	total soluble proteins	966:987	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	8	theme	dry	953:955	arg1	weights					957:963	root dry weights	948:963	root dry weights	948:963	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	9	dep	H2	846:847	arg1	recorded					910:917	recorded	910:917	was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes	906:1234	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	0	10	from	Impact	0:5	arg1	yield					69:73	achene yield	62:73	achene yield	62:73	Impact of exogenously applied trehalose on leaf biochemistry, achene yield and oil composition of sunflower under drought stress.
32562257	0	10	from	Impact	0:5	arg1	composition					83:93	oil composition	79:93	oil composition	79:93	Impact of exogenously applied trehalose on leaf biochemistry, achene yield and oil composition of sunflower under drought stress.
32562257	0	10	from	Impact	0:5	arg1	biochemistry					48:59	leaf biochemistry	43:59	leaf biochemistry	43:59	Impact of exogenously applied trehalose on leaf biochemistry, achene yield and oil composition of sunflower under drought stress.
32562257	4	11	theme	membrane	798:805	arg1	permeability					807:818	relative membrane permeability	789:818	relative membrane permeability	789:818	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	11	theme	membrane	798:805	arg1	RMP					784:786	RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes	784:1234	RMP	784:786	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	6	12	theme	foliar-applied	1421:1434	arg1	trehalose					1436:1444	foliar-applied trehalose	1421:1444	foliar-applied trehalose	1421:1444	Overall, foliar-applied trehalose improved plant growth, oxidative defense system, yield and oil composition of sunflower under drought stress conditions.
32562257	4	13	theme	root	948:951	arg1	proteins					980:987	total soluble proteins	966:987	total soluble proteins	966:987	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	13	theme	root	948:951	arg1	weights					957:963	root dry weights	948:963	root dry weights	948:963	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	1	14	theme	plant	245:249	arg1	tolerance					258:266	plant stress tolerance	245:266	plant stress tolerance	245:266	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	0	15	theme	oil	79:81	arg1	composition					83:93	oil composition	79:93	oil composition	79:93	Impact of exogenously applied trehalose on leaf biochemistry, achene yield and oil composition of sunflower under drought stress.
32562257	3	16	theme	organic	638:644	arg1	growth					553:558	the plant growth	543:558	the plant growth	543:558	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	16	theme	organic	638:644	arg1	contents					646:653	organic contents	638:653	organic contents	638:653	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	4	17	theme	relative	789:796	arg1	permeability					807:818	relative membrane permeability	789:818	relative membrane permeability	789:818	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	17	theme	relative	789:796	arg1	RMP					784:786	RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes	784:1234	RMP	784:786	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	1	18	theme	stress	251:256	arg1	tolerance					258:266	plant stress tolerance	245:266	plant stress tolerance	245:266	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	0	19	theme	sunflower	98:106	arg1	yield					69:73	achene yield	62:73	achene yield	62:73	Impact of exogenously applied trehalose on leaf biochemistry, achene yield and oil composition of sunflower under drought stress.
32562257	0	19	theme	sunflower	98:106	arg1	composition					83:93	oil composition	79:93	oil composition	79:93	Impact of exogenously applied trehalose on leaf biochemistry, achene yield and oil composition of sunflower under drought stress.
32562257	0	19	theme	sunflower	98:106	arg1	biochemistry					48:59	leaf biochemistry	43:59	leaf biochemistry	43:59	Impact of exogenously applied trehalose on leaf biochemistry, achene yield and oil composition of sunflower under drought stress.
32562257	1	20	theme	sunflower	311:319	arg1	Hysun					287:291	Hysun	287:291	Hysun	287:291	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	1	20	theme	sunflower	311:319	arg1	FH					300:301	FH 598	300:305	FH 598	300:305	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	1	20	theme	sunflower	311:319	arg1	cultivars					276:284	two cultivars	272:284	two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions	272:392	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	1	20	theme	sunflower	311:319	arg1	Helianthus					322:331	Helianthus	322:331	Helianthus	322:331	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	4	21	theme	trehalose	752:760	arg1	application					737:747	External application	728:747	External application of trehalose	728:760	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	22	theme	soluble	972:978	arg1	contents					1072:1079	oil contents	1068:1079	oil contents	1068:1079	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	22	theme	soluble	972:978	arg1	proteins					980:987	total soluble proteins	966:987	total soluble proteins	966:987	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	22	theme	soluble	972:978	arg1	yield					1051:1055	achene yield	1044:1055	achene yield per plant	1044:1065	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	22	theme	soluble	972:978	arg1	glycinebetaine					990:1003	glycinebetaine	990:1003	glycinebetaine	990:1003	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	22	theme	soluble	972:978	arg1	weights					957:963	root dry weights	948:963	root dry weights	948:963	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	22	theme	soluble	972:978	arg1	phenolics					1033:1041	total phenolics	1027:1041	total phenolics	1027:1041	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	22	theme	soluble	972:978	arg1	AsA					1006:1008	AsA	1006:1008	AsA (ascorbic acid)	1006:1024	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	2	23	theme	pre-flowering	398:410	arg1	stage					412:416	pre-flowering stage	398:416	pre-flowering stage	398:416	At pre-flowering stage, varying concentrations (10, 20 and 30 mM) of trehalose were applied to the foliage.
32562257	1	24	dep	cultivars	276:284	arg1	Hysun					287:291	Hysun	287:291	Hysun	287:291	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	1	24	dep	cultivars	276:284	arg1	FH					300:301	FH 598	300:305	FH 598	300:305	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	1	24	dep	cultivars	276:284	arg1	cultivars					276:284	two cultivars	272:284	two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions	272:392	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	6	25	theme	oxidative	1469:1477	arg1	system					1487:1492	oxidative defense system	1469:1492	oxidative defense system	1469:1492	Overall, foliar-applied trehalose improved plant growth, oxidative defense system, yield and oil composition of sunflower under drought stress conditions.
32562257	3	26	theme	sunflower	707:715	arg1	cultivars					717:725	both sunflower cultivars	702:725	both sunflower cultivars	702:725	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	4	27	theme	shoot	922:926	arg1	contents					1104:1111	shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents	922:1111	shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents	922:1111	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	5	28	theme	palmitic	1383:1390	arg1	acids					1405:1409	palmitic and linoleic acids	1383:1409	palmitic and linoleic acids	1383:1409	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	5	29	theme	other	1279:1283	arg1	cultivar					1285:1292	the other cultivar	1275:1292	the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids	1275:1409	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	4	30	theme	ascorbic	1011:1018	arg1	AsA					1006:1008	AsA	1006:1008	AsA (ascorbic acid)	1006:1024	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	30	theme	ascorbic	1011:1018	arg1	acid					1020:1023	ascorbic acid	1011:1023	ascorbic acid	1011:1023	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	31	theme	H2	846:847	arg1	accumulation					830:841	the accumulation	826:841	the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes	826:1234	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	31	theme	H2	846:847	arg1	permeability					807:818	relative membrane permeability	789:818	relative membrane permeability	789:818	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	31	theme	H2	846:847	arg1	RMP					784:786	RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes	784:1234	RMP	784:786	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	32	theme	enzymes	1200:1206	arg1	contents					1104:1111	shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents	922:1111	shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents	922:1111	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	32	theme	enzymes	1200:1206	arg1	activities					1122:1131	the activities	1118:1131	the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes	1118:1234	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	5	33	theme	achene	1341:1346	arg1	yield					1348:1352	achene yield	1341:1352	achene yield per plant	1341:1362	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	0	34	theme	applied	22:28	arg1	trehalose					30:38	exogenously applied trehalose	10:38	exogenously applied trehalose	10:38	Impact of exogenously applied trehalose on leaf biochemistry, achene yield and oil composition of sunflower under drought stress.
32562257	5	35	theme	cultivar	1241:1248	arg1	Hysun					1250:1254	The cultivar Hysun 33	1237:1257	The cultivar Hysun 33	1237:1257	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	5	35	theme	cultivar	1241:1248	arg1	superior					1263:1270	superior	1263:1270	superior	1263:1270	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	0	36	theme	drought	114:120	arg1	stress					122:127	drought stress	114:127	drought stress	114:127	Impact of exogenously applied trehalose on leaf biochemistry, achene yield and oil composition of sunflower under drought stress.
32562257	4	37	theme	oil	1068:1070	arg1	proteins					980:987	total soluble proteins	966:987	total soluble proteins	966:987	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	37	theme	oil	1068:1070	arg1	contents					1072:1079	oil contents	1068:1079	oil contents	1068:1079	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	5	38	from	cultivar	1285:1292	arg1	acids					1405:1409	palmitic and linoleic acids	1383:1409	palmitic and linoleic acids	1383:1409	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	5	38	from	cultivar	1285:1292	arg1	contents					1369:1376	oil contents	1365:1376	oil contents	1365:1376	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	5	38	from	cultivar	1285:1292	arg1	yield					1348:1352	achene yield	1341:1352	achene yield per plant	1341:1362	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	5	38	from	cultivar	1285:1292	arg1	RMP					1311:1313	RMP	1311:1313	RMP	1311:1313	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	5	38	from	cultivar	1285:1292	arg1	glycinebetaine					1316:1329	glycinebetaine	1316:1329	glycinebetaine	1316:1329	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	5	38	from	cultivar	1285:1292	arg1	growth					1303:1308	plant growth	1297:1308	plant growth	1297:1308	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	5	38	from	cultivar	1285:1292	arg1	proline					1332:1338	proline	1332:1338	proline	1332:1338	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	5	39	theme	linoleic	1396:1403	arg1	acids					1405:1409	palmitic and linoleic acids	1383:1409	palmitic and linoleic acids	1383:1409	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	3	40	from	contents	646:653	arg1	cultivars					717:725	both sunflower cultivars	702:725	both sunflower cultivars	702:725	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	4	41	theme	water-limited	1214:1226	arg1	regimes					1228:1234	water-limited regimes	1214:1234	water-limited regimes	1214:1234	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	5	42	theme	oil	1365:1367	arg1	contents					1369:1376	oil contents	1365:1376	oil contents	1365:1376	The cultivar Hysun 33 was superior to the other cultivar in plant growth, RMP, glycinebetaine, proline, achene yield per plant, oil contents, and palmitic and linoleic acids.
32562257	2	43	theme	varying	419:425	arg1	concentrations					427:440	varying concentrations	419:440	varying concentrations (10, 20 and 30 mM) of trehalose	419:472	At pre-flowering stage, varying concentrations (10, 20 and 30 mM) of trehalose were applied to the foliage.
32562257	2	44	theme	trehalose	464:472	arg1	concentrations					427:440	varying concentrations	419:440	varying concentrations (10, 20 and 30 mM) of trehalose	419:472	At pre-flowering stage, varying concentrations (10, 20 and 30 mM) of trehalose were applied to the foliage.
32562257	1	45	theme	trehalose	184:192	arg1	influence					171:179	the influence	167:179	the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions	167:392	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	0	46	theme	trehalose	30:38	arg1	Impact					0:5	Impact	0:5	Impact of exogenously applied trehalose on leaf biochemistry, achene yield and oil composition of sunflower under drought stress.	0:128	Impact of exogenously applied trehalose on leaf biochemistry, achene yield and oil composition of sunflower under drought stress.
32562257	4	47	theme	peroxidase	1183:1192	arg1	enzymes					1200:1206	catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes	1136:1206	catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes	1136:1234	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	48	theme	considerable	881:892	arg1	improvement					894:904	a considerable improvement	879:904	a considerable improvement	879:904	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	3	49	theme	total	561:565	arg1	proteins					575:582	total soluble proteins	561:582	total soluble proteins	561:582	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	49	theme	total	561:565	arg1	growth					553:558	the plant growth	543:558	the plant growth	543:558	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	4	50	theme	achene	1044:1049	arg1	proteins					980:987	total soluble proteins	966:987	total soluble proteins	966:987	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	50	theme	achene	1044:1049	arg1	yield					1051:1055	achene yield	1044:1055	achene yield per plant	1044:1065	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	51	theme	hydrogen	853:860	arg1	peroxide					862:869	hydrogen peroxide	853:869	hydrogen peroxide	853:869	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	51	theme	hydrogen	853:860	arg1	H2					846:847	H2	846:847	H2	846:847	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	1	52	dep	Helianthus	322:331	arg1	L.					340:341	Helianthus annuus L.	322:341	Helianthus annuus L.	322:341	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	3	53	from	acids	693:697	arg1	cultivars					717:725	both sunflower cultivars	702:725	both sunflower cultivars	702:725	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	54	theme	soluble	567:573	arg1	proteins					575:582	total soluble proteins	561:582	total soluble proteins	561:582	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	54	theme	soluble	567:573	arg1	growth					553:558	the plant growth	543:558	the plant growth	543:558	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	55	theme	Drought	503:509	arg1	stress					511:516	Drought stress	503:516	Drought stress	503:516	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	4	56	theme	superoxide	1152:1161	arg1	SOD					1174:1176	SOD	1174:1176	SOD	1174:1176	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	56	theme	superoxide	1152:1161	arg1	dismutase					1163:1171	superoxide dismutase	1152:1171	superoxide dismutase (SOD)	1152:1177	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	6	57	theme	oil	1505:1507	arg1	composition					1509:1519	oil composition	1505:1519	oil composition	1505:1519	Overall, foliar-applied trehalose improved plant growth, oxidative defense system, yield and oil composition of sunflower under drought stress conditions.
32562257	0	58	theme	leaf	43:46	arg1	biochemistry					48:59	leaf biochemistry	43:59	leaf biochemistry	43:59	Impact of exogenously applied trehalose on leaf biochemistry, achene yield and oil composition of sunflower under drought stress.
32562257	3	59	theme	oil	667:669	arg1	acids					693:697	oil palmitic and linoleic acids	667:697	oil palmitic and linoleic acids in both sunflower cultivars	667:725	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	59	theme	oil	667:669	arg1	growth					553:558	the plant growth	543:558	the plant growth	543:558	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	2	60	dep	concentrations	427:440	arg1	10					443:444	10	443:444	10	443:444	At pre-flowering stage, varying concentrations (10, 20 and 30 mM) of trehalose were applied to the foliage.
32562257	2	60	dep	concentrations	427:440	arg1	30 mM					454:458	30 mM	454:458	30 mM	454:458	At pre-flowering stage, varying concentrations (10, 20 and 30 mM) of trehalose were applied to the foliage.
32562257	2	60	dep	concentrations	427:440	arg1	20					447:448	20	447:448	20	447:448	At pre-flowering stage, varying concentrations (10, 20 and 30 mM) of trehalose were applied to the foliage.
32562257	3	61	theme	achene	598:603	arg1	growth					553:558	the plant growth	543:558	the plant growth	543:558	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	61	theme	achene	598:603	arg1	yield					605:609	achene yield	598:609	achene yield per plant	598:619	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	4	62	theme	External	728:735	arg1	application					737:747	External application	728:747	External application of trehalose	728:760	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	1	63	from	influence	171:179	arg1	Hysun					287:291	Hysun	287:291	Hysun	287:291	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	1	63	from	influence	171:179	arg1	FH					300:301	FH 598	300:305	FH 598	300:305	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	1	63	from	influence	171:179	arg1	cultivars					276:284	two cultivars	272:284	two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions	272:392	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	1	63	from	influence	171:179	arg1	Helianthus					322:331	Helianthus	322:331	Helianthus	322:331	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	6	64	theme	defense	1479:1485	arg1	system					1487:1492	oxidative defense system	1469:1492	oxidative defense system	1469:1492	Overall, foliar-applied trehalose improved plant growth, oxidative defense system, yield and oil composition of sunflower under drought stress conditions.
32562257	3	65	theme	palmitic	671:678	arg1	acids					693:697	oil palmitic and linoleic acids	667:697	oil palmitic and linoleic acids in both sunflower cultivars	667:725	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	65	theme	palmitic	671:678	arg1	growth					553:558	the plant growth	543:558	the plant growth	543:558	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	1	66	theme	control	356:362	arg1	conditions					383:392	control and drought stress conditions	356:392	control and drought stress conditions	356:392	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	6	67	theme	stress	1548:1553	arg1	conditions					1555:1564	drought stress conditions	1540:1564	drought stress conditions	1540:1564	Overall, foliar-applied trehalose improved plant growth, oxidative defense system, yield and oil composition of sunflower under drought stress conditions.
32562257	6	68	theme	plant	1455:1459	arg1	growth					1461:1466	plant growth	1455:1466	plant growth	1455:1466	Overall, foliar-applied trehalose improved plant growth, oxidative defense system, yield and oil composition of sunflower under drought stress conditions.
32562257	4	69	theme	fresh	928:932	arg1	contents					1104:1111	shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents	922:1111	shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents	922:1111	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	1	70	theme	non-reducing	197:208	arg1	disaccharide					210:221	a non-reducing disaccharide	195:221	a non-reducing disaccharide involved in improving plant stress tolerance	195:266	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	1	70	theme	non-reducing	197:208	arg1	trehalose					184:192	trehalose	184:192	trehalose	184:192	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	0	71	theme	achene	62:67	arg1	yield					69:73	achene yield	62:73	achene yield	62:73	Impact of exogenously applied trehalose on leaf biochemistry, achene yield and oil composition of sunflower under drought stress.
32562257	1	72	theme	drought	368:374	arg1	conditions					383:392	control and drought stress conditions	356:392	control and drought stress conditions	356:392	This study was carried out to assess the influence of trehalose, a non-reducing disaccharide involved in improving plant stress tolerance, on two cultivars (Hysun 33 and FH 598) of sunflower (Helianthus annuus L.) grown under control and drought stress conditions.
32562257	4	73	theme	total	966:970	arg1	contents					1072:1079	oil contents	1068:1079	oil contents	1068:1079	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	73	theme	total	966:970	arg1	proteins					980:987	total soluble proteins	966:987	total soluble proteins	966:987	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	73	theme	total	966:970	arg1	yield					1051:1055	achene yield	1044:1055	achene yield per plant	1044:1065	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	73	theme	total	966:970	arg1	glycinebetaine					990:1003	glycinebetaine	990:1003	glycinebetaine	990:1003	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	73	theme	total	966:970	arg1	weights					957:963	root dry weights	948:963	root dry weights	948:963	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	73	theme	total	966:970	arg1	phenolics					1033:1041	total phenolics	1027:1041	total phenolics	1027:1041	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	4	73	theme	total	966:970	arg1	AsA					1006:1008	AsA	1006:1008	AsA (ascorbic acid)	1006:1024	External application of trehalose significantly reduced RMP (relative membrane permeability), and the accumulation of H2 O2 (hydrogen peroxide), while a considerable improvement was recorded in shoot fresh and shoot and root dry weights, total soluble proteins, glycinebetaine, AsA (ascorbic acid), total phenolics, achene yield per plant, oil contents, inorganic and organic contents, and the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD) enzymes under water-limited regimes.
32562257	6	74	theme	drought	1540:1546	arg1	conditions					1555:1564	drought stress conditions	1540:1564	drought stress conditions	1540:1564	Overall, foliar-applied trehalose improved plant growth, oxidative defense system, yield and oil composition of sunflower under drought stress conditions.
32562257	3	75	theme	plant	547:551	arg1	contents					646:653	organic contents	638:653	organic contents	638:653	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	75	theme	plant	547:551	arg1	proteins					575:582	total soluble proteins	561:582	total soluble proteins	561:582	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	75	theme	plant	547:551	arg1	growth					553:558	the plant growth	543:558	the plant growth	543:558	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	75	theme	plant	547:551	arg1	chlorophyll					585:595	chlorophyll	585:595	chlorophyll	585:595	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	75	theme	plant	547:551	arg1	acids					693:697	oil palmitic and linoleic acids	667:697	oil palmitic and linoleic acids in both sunflower cultivars	667:725	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	75	theme	plant	547:551	arg1	percentage					626:635	oil percentage	622:635	oil percentage	622:635	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	75	theme	plant	547:551	arg1	yield					605:609	achene yield	598:609	achene yield per plant	598:619	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	76	theme	linoleic	684:691	arg1	acids					693:697	oil palmitic and linoleic acids	667:697	oil palmitic and linoleic acids in both sunflower cultivars	667:725	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
32562257	3	76	theme	linoleic	684:691	arg1	growth					553:558	the plant growth	543:558	the plant growth	543:558	Drought stress significantly suppressed the plant growth, total soluble proteins, chlorophyll, achene yield per plant, oil percentage, organic contents, as well as oil palmitic and linoleic acids in both sunflower cultivars.
31941018	6	0	theme	upper	936:940	arg1	nanoparticles					897:909	chitosan nanoparticles	888:909	chitosan nanoparticles that were attached as an upper layer	888:946	A solution of macromolecular chitosan was applied onto foils as a first layer, followed by the deposition of various extracts embedded into chitosan nanoparticles that were attached as an upper layer.
31941018	6	0	theme	upper	936:940	arg1	layer					942:946	an upper layer	933:946	an upper layer	933:946	A solution of macromolecular chitosan was applied onto foils as a first layer, followed by the deposition of various extracts embedded into chitosan nanoparticles that were attached as an upper layer.
31941018	8	1	theme	physico-chemical	1144:1159	arg1	analyses					1161:1168	The physico-chemical analyses	1140:1168	The physico-chemical analyses of functionalized foils	1140:1192	The physico-chemical analyses of functionalized foils were thus comprised of surface elemental composition, surface charge, wettability, as well as surface morphology.
31941018	0	2	theme	Colloidal	87:95	arg1	Formulations					97:108	Colloidal Formulations	87:108	Colloidal Formulations	87:108	Physicochemical Characterization of Packaging Foils Coated by Chitosan and Polyphenols Colloidal Formulations.
31941018	7	3	theme	bioactive	984:992	arg1	efficiency					994:1003	bioactive efficiency	984:1003	bioactive efficiency	984:1003	Since active packaging must assure bioactive efficiency at the interface with food, it is extremely important to understand the surface characteristics and phenomena of functionalized foils.
31941018	4	4	theme	nanoparticle	685:696	arg1	dispersions					698:708	chitosan-extracts nanoparticle dispersions	667:708	chitosan-extracts nanoparticle dispersions	667:708	Two representative, commercially used foils, polypropylene (PP) and polyethylene (PE), previously activated by UV/ozone to improve coating adhesion, were functionalized using chitosan-extracts nanoparticle dispersions.
31941018	3	5	theme	embedded	391:398	arg1	extracts					429:436	embedded thyme, rosemary and cinnamon extracts	391:436	embedded thyme, rosemary and cinnamon extracts	391:436	Chitosan nanoparticles with embedded thyme, rosemary and cinnamon extracts were synthesized, and characterized for this purpose.
31941018	2	6	theme	chitosan	289:296	arg1	extracts					322:329	chitosan and antioxidative plant extracts	289:329	chitosan and antioxidative plant extracts	289:329	The aim of our research was to establish an additive formulation of chitosan and antioxidative plant extracts as dispersion of nanoparticles.
31941018	3	7	theme	Chitosan	363:370	arg1	nanoparticles					372:384	Chitosan nanoparticles	363:384	Chitosan nanoparticles with embedded thyme, rosemary and cinnamon extracts	363:436	Chitosan nanoparticles with embedded thyme, rosemary and cinnamon extracts were synthesized, and characterized for this purpose.
31941018	4	8	theme	representative	496:509	arg1	polyethylene					560:571	polyethylene	560:571	polyethylene (PE)	560:576	Two representative, commercially used foils, polypropylene (PP) and polyethylene (PE), previously activated by UV/ozone to improve coating adhesion, were functionalized using chitosan-extracts nanoparticle dispersions.
31941018	4	8	theme	representative	496:509	arg1	polypropylene					537:549	polypropylene	537:549	polypropylene (PP)	537:554	Two representative, commercially used foils, polypropylene (PP) and polyethylene (PE), previously activated by UV/ozone to improve coating adhesion, were functionalized using chitosan-extracts nanoparticle dispersions.
31941018	4	8	theme	representative	496:509	arg1	foils					530:534	Two representative, commercially used foils	492:534	Two representative, commercially used foils	492:534	Two representative, commercially used foils, polypropylene (PP) and polyethylene (PE), previously activated by UV/ozone to improve coating adhesion, were functionalized using chitosan-extracts nanoparticle dispersions.
31941018	7	9	theme	functionalized	1118:1131	arg1	foils					1133:1137	functionalized foils	1118:1137	functionalized foils	1118:1137	Since active packaging must assure bioactive efficiency at the interface with food, it is extremely important to understand the surface characteristics and phenomena of functionalized foils.
31941018	1	10	used	used	171:174	arg2	chitosan					158:165	antimicrobial polysaccharide chitosan	129:165	antimicrobial polysaccharide chitosan	129:165	In this research, antimicrobial polysaccharide chitosan was used as a surface coating for packaging material.
31941018	1	10	used	used	171:174	arg2	coating					189:195	a surface coating	179:195	a surface coating for packaging material	179:218	In this research, antimicrobial polysaccharide chitosan was used as a surface coating for packaging material.
31941018	1	11	theme	surface	181:187	arg1	chitosan					158:165	antimicrobial polysaccharide chitosan	129:165	antimicrobial polysaccharide chitosan	129:165	In this research, antimicrobial polysaccharide chitosan was used as a surface coating for packaging material.
31941018	1	11	theme	surface	181:187	arg1	coating					189:195	a surface coating	179:195	a surface coating for packaging material	179:218	In this research, antimicrobial polysaccharide chitosan was used as a surface coating for packaging material.
31941018	7	12	theme	foils	1133:1137	arg1	phenomena					1105:1113	phenomena	1105:1113	phenomena	1105:1113	Since active packaging must assure bioactive efficiency at the interface with food, it is extremely important to understand the surface characteristics and phenomena of functionalized foils.
31941018	7	12	theme	foils	1133:1137	arg1	characteristics					1085:1099	the surface characteristics	1073:1099	the surface characteristics	1073:1099	Since active packaging must assure bioactive efficiency at the interface with food, it is extremely important to understand the surface characteristics and phenomena of functionalized foils.
31941018	6	13	theme	first	814:818	arg1	solution					750:757	A solution	748:757	A solution of macromolecular chitosan	748:784	A solution of macromolecular chitosan was applied onto foils as a first layer, followed by the deposition of various extracts embedded into chitosan nanoparticles that were attached as an upper layer.
31941018	6	13	theme	first	814:818	arg1	layer					820:824	a first layer	812:824	a first layer	812:824	A solution of macromolecular chitosan was applied onto foils as a first layer, followed by the deposition of various extracts embedded into chitosan nanoparticles that were attached as an upper layer.
31941018	8	14	theme	elemental	1225:1233	arg1	composition					1235:1245	surface elemental composition	1217:1245	surface elemental composition	1217:1245	The physico-chemical analyses of functionalized foils were thus comprised of surface elemental composition, surface charge, wettability, as well as surface morphology.
31941018	4	15	theme	chitosan-extracts	667:683	arg1	dispersions					698:708	chitosan-extracts nanoparticle dispersions	667:708	chitosan-extracts nanoparticle dispersions	667:708	Two representative, commercially used foils, polypropylene (PP) and polyethylene (PE), previously activated by UV/ozone to improve coating adhesion, were functionalized using chitosan-extracts nanoparticle dispersions.
31941018	3	16	theme	rosemary	407:414	arg1	extracts					429:436	embedded thyme, rosemary and cinnamon extracts	391:436	embedded thyme, rosemary and cinnamon extracts	391:436	Chitosan nanoparticles with embedded thyme, rosemary and cinnamon extracts were synthesized, and characterized for this purpose.
31941018	4	17	dep	representative	496:509	arg1	used					525:528	used	525:528	used	525:528	Two representative, commercially used foils, polypropylene (PP) and polyethylene (PE), previously activated by UV/ozone to improve coating adhesion, were functionalized using chitosan-extracts nanoparticle dispersions.
31941018	10	18	theme	foils	1596:1600	arg1	wettability					1581:1591	the wettability	1577:1591	the wettability of foils	1577:1600	Moreover, the wettability of foils was improved in order to minimize the anti-fogging behavior.
31941018	9	19	with	contact	1548:1554	arg1	food					1561:1564	food	1561:1564	food	1561:1564	It has been shown that coatings were applied successfully with an elemental composition, surface charge and morphology that should enable coating stability, homogeneity and consequently provide an active concept of the packaging surface in contact with food.
31941018	8	20	theme	surface	1288:1294	arg1	morphology					1296:1305	surface morphology	1288:1305	surface morphology	1288:1305	The physico-chemical analyses of functionalized foils were thus comprised of surface elemental composition, surface charge, wettability, as well as surface morphology.
31941018	0	21	theme	Physicochemical	0:14	arg1	Characterization					16:31	Physicochemical Characterization	0:31	Physicochemical Characterization of Packaging Foils	0:50	Physicochemical Characterization of Packaging Foils Coated by Chitosan and Polyphenols Colloidal Formulations.
31941018	0	22	theme	Packaging	36:44	arg1	Foils					46:50	Packaging Foils	36:50	Packaging Foils	36:50	Physicochemical Characterization of Packaging Foils Coated by Chitosan and Polyphenols Colloidal Formulations.
31941018	2	23	theme	extracts	322:329	arg1	formulation					274:284	an additive formulation	262:284	an additive formulation of chitosan and antioxidative plant extracts as dispersion of nanoparticles	262:360	The aim of our research was to establish an additive formulation of chitosan and antioxidative plant extracts as dispersion of nanoparticles.
31941018	1	24	theme	packaging	201:209	arg1	material					211:218	packaging material	201:218	packaging material	201:218	In this research, antimicrobial polysaccharide chitosan was used as a surface coating for packaging material.
31941018	3	25	theme	thyme	400:404	arg1	extracts					429:436	embedded thyme, rosemary and cinnamon extracts	391:436	embedded thyme, rosemary and cinnamon extracts	391:436	Chitosan nanoparticles with embedded thyme, rosemary and cinnamon extracts were synthesized, and characterized for this purpose.
31941018	9	26	theme	elemental	1374:1382	arg1	composition					1384:1394	an elemental composition	1371:1394	an elemental composition	1371:1394	It has been shown that coatings were applied successfully with an elemental composition, surface charge and morphology that should enable coating stability, homogeneity and consequently provide an active concept of the packaging surface in contact with food.
31941018	8	27	theme	surface	1248:1254	arg1	charge					1256:1261	surface charge	1248:1261	surface charge	1248:1261	The physico-chemical analyses of functionalized foils were thus comprised of surface elemental composition, surface charge, wettability, as well as surface morphology.
31941018	2	28	theme	plant	316:320	arg1	extracts					322:329	chitosan and antioxidative plant extracts	289:329	chitosan and antioxidative plant extracts	289:329	The aim of our research was to establish an additive formulation of chitosan and antioxidative plant extracts as dispersion of nanoparticles.
31941018	6	29	theme	chitosan	888:895	arg1	nanoparticles					897:909	chitosan nanoparticles	888:909	chitosan nanoparticles that were attached as an upper layer	888:946	A solution of macromolecular chitosan was applied onto foils as a first layer, followed by the deposition of various extracts embedded into chitosan nanoparticles that were attached as an upper layer.
31941018	6	29	theme	chitosan	888:895	arg1	layer					942:946	an upper layer	933:946	an upper layer	933:946	A solution of macromolecular chitosan was applied onto foils as a first layer, followed by the deposition of various extracts embedded into chitosan nanoparticles that were attached as an upper layer.
31941018	2	30	theme	antioxidative	302:314	arg1	extracts					322:329	chitosan and antioxidative plant extracts	289:329	chitosan and antioxidative plant extracts	289:329	The aim of our research was to establish an additive formulation of chitosan and antioxidative plant extracts as dispersion of nanoparticles.
31941018	2	31	theme	nanoparticles	348:360	arg1	dispersion					334:343	dispersion	334:343	dispersion of nanoparticles	334:360	The aim of our research was to establish an additive formulation of chitosan and antioxidative plant extracts as dispersion of nanoparticles.
31941018	0	32	dep	Chitosan	62:69	arg1	Formulations					97:108	Colloidal Formulations	87:108	Colloidal Formulations	87:108	Physicochemical Characterization of Packaging Foils Coated by Chitosan and Polyphenols Colloidal Formulations.
31941018	9	33	theme	active	1505:1510	arg1	concept					1512:1518	an active concept	1502:1518	an active concept of the packaging surface in contact with food	1502:1564	It has been shown that coatings were applied successfully with an elemental composition, surface charge and morphology that should enable coating stability, homogeneity and consequently provide an active concept of the packaging surface in contact with food.
31941018	0	34	theme	Foils	46:50	arg1	Characterization					16:31	Physicochemical Characterization	0:31	Physicochemical Characterization of Packaging Foils	0:50	Physicochemical Characterization of Packaging Foils Coated by Chitosan and Polyphenols Colloidal Formulations.
31941018	9	35	theme	surface	1397:1403	arg1	charge					1405:1410	surface charge	1397:1410	surface charge	1397:1410	It has been shown that coatings were applied successfully with an elemental composition, surface charge and morphology that should enable coating stability, homogeneity and consequently provide an active concept of the packaging surface in contact with food.
31941018	7	36	theme	surface	1077:1083	arg1	characteristics					1085:1099	the surface characteristics	1073:1099	the surface characteristics	1073:1099	Since active packaging must assure bioactive efficiency at the interface with food, it is extremely important to understand the surface characteristics and phenomena of functionalized foils.
31941018	8	37	theme	foils	1188:1192	arg1	analyses					1161:1168	The physico-chemical analyses	1140:1168	The physico-chemical analyses of functionalized foils	1140:1192	The physico-chemical analyses of functionalized foils were thus comprised of surface elemental composition, surface charge, wettability, as well as surface morphology.
31941018	2	38	theme	research	236:243	arg1	aim					225:227	The aim	221:227	The aim of our research	221:243	The aim of our research was to establish an additive formulation of chitosan and antioxidative plant extracts as dispersion of nanoparticles.
31941018	9	39	theme	packaging	1527:1535	arg1	surface					1537:1543	the packaging surface	1523:1543	the packaging surface	1523:1543	It has been shown that coatings were applied successfully with an elemental composition, surface charge and morphology that should enable coating stability, homogeneity and consequently provide an active concept of the packaging surface in contact with food.
31941018	3	40	theme	cinnamon	420:427	arg1	extracts					429:436	embedded thyme, rosemary and cinnamon extracts	391:436	embedded thyme, rosemary and cinnamon extracts	391:436	Chitosan nanoparticles with embedded thyme, rosemary and cinnamon extracts were synthesized, and characterized for this purpose.
31941018	6	41	dep	extracts	865:872	arg1	embedded					874:881	embedded	874:881	embedded	874:881	A solution of macromolecular chitosan was applied onto foils as a first layer, followed by the deposition of various extracts embedded into chitosan nanoparticles that were attached as an upper layer.
31941018	6	42	theme	extracts	865:872	arg1	deposition					843:852	the deposition	839:852	the deposition of various extracts embedded into chitosan nanoparticles that were attached as an upper layer	839:946	A solution of macromolecular chitosan was applied onto foils as a first layer, followed by the deposition of various extracts embedded into chitosan nanoparticles that were attached as an upper layer.
31941018	9	43	theme	surface	1537:1543	arg1	concept					1512:1518	an active concept	1502:1518	an active concept of the packaging surface in contact with food	1502:1564	It has been shown that coatings were applied successfully with an elemental composition, surface charge and morphology that should enable coating stability, homogeneity and consequently provide an active concept of the packaging surface in contact with food.
31941018	6	44	theme	various	857:863	arg1	extracts					865:872	various extracts	857:872	various extracts embedded into chitosan nanoparticles that were attached as an upper layer	857:946	A solution of macromolecular chitosan was applied onto foils as a first layer, followed by the deposition of various extracts embedded into chitosan nanoparticles that were attached as an upper layer.
31941018	9	45	from	concept	1512:1518	arg1	contact					1548:1554	contact	1548:1554	contact with food	1548:1564	It has been shown that coatings were applied successfully with an elemental composition, surface charge and morphology that should enable coating stability, homogeneity and consequently provide an active concept of the packaging surface in contact with food.
31941018	1	46	theme	antimicrobial	129:141	arg1	chitosan					158:165	antimicrobial polysaccharide chitosan	129:165	antimicrobial polysaccharide chitosan	129:165	In this research, antimicrobial polysaccharide chitosan was used as a surface coating for packaging material.
31941018	1	46	theme	antimicrobial	129:141	arg1	coating					189:195	a surface coating	179:195	a surface coating for packaging material	179:218	In this research, antimicrobial polysaccharide chitosan was used as a surface coating for packaging material.
31941018	7	47	theme	active	955:960	arg1	packaging					962:970	active packaging	955:970	active packaging	955:970	Since active packaging must assure bioactive efficiency at the interface with food, it is extremely important to understand the surface characteristics and phenomena of functionalized foils.
31941018	2	48	theme	additive	265:272	arg1	formulation					274:284	an additive formulation	262:284	an additive formulation of chitosan and antioxidative plant extracts as dispersion of nanoparticles	262:360	The aim of our research was to establish an additive formulation of chitosan and antioxidative plant extracts as dispersion of nanoparticles.
31941018	3	49	with	nanoparticles	372:384	arg1	extracts					429:436	embedded thyme, rosemary and cinnamon extracts	391:436	embedded thyme, rosemary and cinnamon extracts	391:436	Chitosan nanoparticles with embedded thyme, rosemary and cinnamon extracts were synthesized, and characterized for this purpose.
31941018	1	50	theme	polysaccharide	143:156	arg1	chitosan					158:165	antimicrobial polysaccharide chitosan	129:165	antimicrobial polysaccharide chitosan	129:165	In this research, antimicrobial polysaccharide chitosan was used as a surface coating for packaging material.
31941018	1	50	theme	polysaccharide	143:156	arg1	coating					189:195	a surface coating	179:195	a surface coating for packaging material	179:218	In this research, antimicrobial polysaccharide chitosan was used as a surface coating for packaging material.
31941018	6	51	theme	chitosan	777:784	arg1	solution					750:757	A solution	748:757	A solution of macromolecular chitosan	748:784	A solution of macromolecular chitosan was applied onto foils as a first layer, followed by the deposition of various extracts embedded into chitosan nanoparticles that were attached as an upper layer.
31941018	6	51	theme	chitosan	777:784	arg1	layer					820:824	a first layer	812:824	a first layer	812:824	A solution of macromolecular chitosan was applied onto foils as a first layer, followed by the deposition of various extracts embedded into chitosan nanoparticles that were attached as an upper layer.
31941018	6	52	theme	macromolecular	762:775	arg1	chitosan					777:784	macromolecular chitosan	762:784	macromolecular chitosan	762:784	A solution of macromolecular chitosan was applied onto foils as a first layer, followed by the deposition of various extracts embedded into chitosan nanoparticles that were attached as an upper layer.
31941018	8	53	theme	functionalized	1173:1186	arg1	foils					1188:1192	functionalized foils	1173:1192	functionalized foils	1173:1192	The physico-chemical analyses of functionalized foils were thus comprised of surface elemental composition, surface charge, wettability, as well as surface morphology.
31941018	8	54	theme	surface	1217:1223	arg1	composition					1235:1245	surface elemental composition	1217:1245	surface elemental composition	1217:1245	The physico-chemical analyses of functionalized foils were thus comprised of surface elemental composition, surface charge, wettability, as well as surface morphology.
31941018	7	55	with	interface	1012:1020	arg1	food					1027:1030	food	1027:1030	food	1027:1030	Since active packaging must assure bioactive efficiency at the interface with food, it is extremely important to understand the surface characteristics and phenomena of functionalized foils.
31941018	10	56	theme	anti-fogging	1640:1651	arg1	behavior					1653:1660	the anti-fogging behavior	1636:1660	the anti-fogging behavior	1636:1660	Moreover, the wettability of foils was improved in order to minimize the anti-fogging behavior.
31941018	4	57	theme	coating	623:629	arg1	adhesion					631:638	coating adhesion	623:638	coating adhesion	623:638	Two representative, commercially used foils, polypropylene (PP) and polyethylene (PE), previously activated by UV/ozone to improve coating adhesion, were functionalized using chitosan-extracts nanoparticle dispersions.
32829873	6	0	theme	fecal	699:703	arg1	culture					705:711	the fecal culture	695:711	the fecal culture of ACNP	695:719	The results showed that ACNP was digested by gut microbiota, while the pH value in the fecal culture of ACNP was greatly decreased, and total short-chain fatty acids, acetic, propionic, i-valeric and n-valeric acids were significantly increased.
32829873	3	1	theme	gel-filtration	330:343	arg1	chromatography					352:365	gel-filtration column chromatography	330:365	gel-filtration column chromatography	330:365	by ion-exchange and gel-filtration column chromatography.
32829873	5	2	theme	fecal	596:600	arg1	cultures					602:609	human fecal cultures	590:609	human fecal cultures	590:609	The impacts of ACNP on gut microbiota were then investigated by in vitro fermentation with human fecal cultures.
32829873	1	3	theme	Asparagus	160:168	arg1	polysaccharide					194:207	Asparagus cochinchinensis neutral polysaccharide	160:207	Asparagus cochinchinensis neutral polysaccharide	160:207	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	1	3	theme	Asparagus	160:168	arg1	ACNP					154:157	A purified inulin-type fructan named ACNP	117:157	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da	117:250	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	0	4	theme	intestinal	94:103	arg1	microbiota					105:114	human intestinal microbiota	88:114	human intestinal microbiota	88:114	A novel inulin-type fructan from Asparagus cochinchinensis and its beneficial impact on human intestinal microbiota.
32829873	6	5	theme	short-chain	754:764	arg1	acids					772:776	total short-chain fatty acids	748:776	total short-chain fatty acids	748:776	The results showed that ACNP was digested by gut microbiota, while the pH value in the fecal culture of ACNP was greatly decreased, and total short-chain fatty acids, acetic, propionic, i-valeric and n-valeric acids were significantly increased.
32829873	7	6	theme	Prevotella	945:954	arg1	growth					935:940	the growth	931:940	the growth of Prevotella, Megamonas, and Bifidobacterium	931:986	Moreover, ACNP regulated the fecal microbiota composition by stimulating the growth of Prevotella, Megamonas, and Bifidobacterium while depleting Haemophilus.
32829873	4	7	theme	linear	411:416	arg1	backbone					418:425	a linear backbone	409:425	a linear backbone composed of 2,1-β-D-Fruf residues	409:459	Structural analyses reveal that ACNP has a linear backbone composed of 2,1-β-D-Fruf residues, ending with a (1→2) bonded α-D-Glcp.
32829873	6	8	from	value	686:690	arg1	culture					705:711	the fecal culture	695:711	the fecal culture of ACNP	695:719	The results showed that ACNP was digested by gut microbiota, while the pH value in the fecal culture of ACNP was greatly decreased, and total short-chain fatty acids, acetic, propionic, i-valeric and n-valeric acids were significantly increased.
32829873	7	9	theme	Megamonas	957:965	arg1	growth					935:940	the growth	931:940	the growth of Prevotella, Megamonas, and Bifidobacterium	931:986	Moreover, ACNP regulated the fecal microbiota composition by stimulating the growth of Prevotella, Megamonas, and Bifidobacterium while depleting Haemophilus.
32829873	1	10	theme	Asparagus	270:278	arg1	cochinchinensis					280:294	Asparagus cochinchinensis	270:294	Asparagus cochinchinensis	270:294	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	0	11	theme	human	88:92	arg1	microbiota					105:114	human intestinal microbiota	88:114	human intestinal microbiota	88:114	A novel inulin-type fructan from Asparagus cochinchinensis and its beneficial impact on human intestinal microbiota.
32829873	4	12	theme	bonded	482:487	arg1	α-D-Glcp					489:496	a (1→2) bonded α-D-Glcp	474:496	a (1→2) bonded α-D-Glcp	474:496	Structural analyses reveal that ACNP has a linear backbone composed of 2,1-β-D-Fruf residues, ending with a (1→2) bonded α-D-Glcp.
32829873	1	13	with	ACNP	154:157	arg1	weight					234:239	apparent molecular weight	215:239	apparent molecular weight of 2690 Da	215:250	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	6	14	theme	pH	683:684	arg1	value					686:690	the pH value	679:690	the pH value in the fecal culture of ACNP	679:719	The results showed that ACNP was digested by gut microbiota, while the pH value in the fecal culture of ACNP was greatly decreased, and total short-chain fatty acids, acetic, propionic, i-valeric and n-valeric acids were significantly increased.
32829873	0	15	from	cochinchinensis	43:57	arg1	impact					78:83	its beneficial impact	63:83	its beneficial impact on human intestinal microbiota	63:114	A novel inulin-type fructan from Asparagus cochinchinensis and its beneficial impact on human intestinal microbiota.
32829873	0	15	from	cochinchinensis	43:57	arg1	fructan					20:26	A novel inulin-type fructan	0:26	A novel inulin-type fructan from Asparagus cochinchinensis	0:57	A novel inulin-type fructan from Asparagus cochinchinensis and its beneficial impact on human intestinal microbiota.
32829873	5	16	dep	in	563:564	arg1	vitro					566:570	vitro	566:570	vitro	566:570	The impacts of ACNP on gut microbiota were then investigated by in vitro fermentation with human fecal cultures.
32829873	1	17	theme	cochinchinensis	170:184	arg1	polysaccharide					194:207	Asparagus cochinchinensis neutral polysaccharide	160:207	Asparagus cochinchinensis neutral polysaccharide	160:207	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	1	17	theme	cochinchinensis	170:184	arg1	ACNP					154:157	A purified inulin-type fructan named ACNP	117:157	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da	117:250	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	6	18	theme	fatty	766:770	arg1	acids					772:776	total short-chain fatty acids	748:776	total short-chain fatty acids	748:776	The results showed that ACNP was digested by gut microbiota, while the pH value in the fecal culture of ACNP was greatly decreased, and total short-chain fatty acids, acetic, propionic, i-valeric and n-valeric acids were significantly increased.
32829873	1	19	theme	neutral	186:192	arg1	polysaccharide					194:207	Asparagus cochinchinensis neutral polysaccharide	160:207	Asparagus cochinchinensis neutral polysaccharide	160:207	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	1	19	theme	neutral	186:192	arg1	ACNP					154:157	A purified inulin-type fructan named ACNP	117:157	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da	117:250	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	0	20	theme	novel	2:6	arg1	fructan					20:26	A novel inulin-type fructan	0:26	A novel inulin-type fructan from Asparagus cochinchinensis	0:57	A novel inulin-type fructan from Asparagus cochinchinensis and its beneficial impact on human intestinal microbiota.
32829873	3	21	theme	column	345:350	arg1	chromatography					352:365	gel-filtration column chromatography	330:365	gel-filtration column chromatography	330:365	by ion-exchange and gel-filtration column chromatography.
32829873	8	22	contain	has	1135:1137	arg1	ACNP					1130:1133	ACNP	1130:1133	ACNP	1130:1133	Collectively, these results indicated that ACNP beneficially regulates gut microbiota, which thus suggested that ACNP has the potential to be used as a dietary supplement or drug to improve health.
32829873	8	22	contain	has	1135:1137	arg2	potential					1143:1151	the potential to be used as a dietary supplement or drug to improve health	1139:1212	the potential to be used as a dietary supplement or drug to improve health	1139:1212	Collectively, these results indicated that ACNP beneficially regulates gut microbiota, which thus suggested that ACNP has the potential to be used as a dietary supplement or drug to improve health.
32829873	5	23	theme	ACNP	514:517	arg1	impacts					503:509	The impacts	499:509	The impacts of ACNP on gut microbiota	499:535	The impacts of ACNP on gut microbiota were then investigated by in vitro fermentation with human fecal cultures.
32829873	6	24	theme	total	748:752	arg1	acids					772:776	total short-chain fatty acids	748:776	total short-chain fatty acids	748:776	The results showed that ACNP was digested by gut microbiota, while the pH value in the fecal culture of ACNP was greatly decreased, and total short-chain fatty acids, acetic, propionic, i-valeric and n-valeric acids were significantly increased.
32829873	7	25	theme	microbiota	893:902	arg1	composition					904:914	the fecal microbiota composition	883:914	the fecal microbiota composition	883:914	Moreover, ACNP regulated the fecal microbiota composition by stimulating the growth of Prevotella, Megamonas, and Bifidobacterium while depleting Haemophilus.
32829873	5	26	theme	human	590:594	arg1	cultures					602:609	human fecal cultures	590:609	human fecal cultures	590:609	The impacts of ACNP on gut microbiota were then investigated by in vitro fermentation with human fecal cultures.
32829873	6	27	theme	acetic	779:784	arg1	acids					772:776	total short-chain fatty acids	748:776	total short-chain fatty acids	748:776	The results showed that ACNP was digested by gut microbiota, while the pH value in the fecal culture of ACNP was greatly decreased, and total short-chain fatty acids, acetic, propionic, i-valeric and n-valeric acids were significantly increased.
32829873	0	28	theme	inulin-type	8:18	arg1	fructan					20:26	A novel inulin-type fructan	0:26	A novel inulin-type fructan from Asparagus cochinchinensis	0:57	A novel inulin-type fructan from Asparagus cochinchinensis and its beneficial impact on human intestinal microbiota.
32829873	1	29	theme	apparent	215:222	arg1	weight					234:239	apparent molecular weight	215:239	apparent molecular weight of 2690 Da	215:250	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	0	30	theme	Asparagus	33:41	arg1	cochinchinensis					43:57	Asparagus cochinchinensis	33:57	Asparagus cochinchinensis	33:57	A novel inulin-type fructan from Asparagus cochinchinensis and its beneficial impact on human intestinal microbiota.
32829873	5	31	with	fermentation	572:583	arg1	cultures					602:609	human fecal cultures	590:609	human fecal cultures	590:609	The impacts of ACNP on gut microbiota were then investigated by in vitro fermentation with human fecal cultures.
32829873	0	32	from	impact	78:83	arg1	microbiota					105:114	human intestinal microbiota	88:114	human intestinal microbiota	88:114	A novel inulin-type fructan from Asparagus cochinchinensis and its beneficial impact on human intestinal microbiota.
32829873	6	33	dep	acetic	779:784	arg1	i-valeric					798:806	i-valeric	798:806	i-valeric	798:806	The results showed that ACNP was digested by gut microbiota, while the pH value in the fecal culture of ACNP was greatly decreased, and total short-chain fatty acids, acetic, propionic, i-valeric and n-valeric acids were significantly increased.
32829873	6	33	dep	acetic	779:784	arg1	propionic					787:795	propionic	787:795	propionic	787:795	The results showed that ACNP was digested by gut microbiota, while the pH value in the fecal culture of ACNP was greatly decreased, and total short-chain fatty acids, acetic, propionic, i-valeric and n-valeric acids were significantly increased.
32829873	1	34	theme	molecular	224:232	arg1	weight					234:239	apparent molecular weight	215:239	apparent molecular weight of 2690 Da	215:250	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	8	35	theme	gut	1088:1090	arg1	microbiota					1092:1101	gut microbiota	1088:1101	gut microbiota	1088:1101	Collectively, these results indicated that ACNP beneficially regulates gut microbiota, which thus suggested that ACNP has the potential to be used as a dietary supplement or drug to improve health.
32829873	4	36	theme	Structural	368:377	arg1	analyses					379:386	Structural analyses	368:386	Structural analyses	368:386	Structural analyses reveal that ACNP has a linear backbone composed of 2,1-β-D-Fruf residues, ending with a (1→2) bonded α-D-Glcp.
32829873	6	37	theme	n-valeric	812:820	arg1	acids					822:826	n-valeric acids	812:826	n-valeric acids	812:826	The results showed that ACNP was digested by gut microbiota, while the pH value in the fecal culture of ACNP was greatly decreased, and total short-chain fatty acids, acetic, propionic, i-valeric and n-valeric acids were significantly increased.
32829873	7	38	theme	Bifidobacterium	972:986	arg1	growth					935:940	the growth	931:940	the growth of Prevotella, Megamonas, and Bifidobacterium	931:986	Moreover, ACNP regulated the fecal microbiota composition by stimulating the growth of Prevotella, Megamonas, and Bifidobacterium while depleting Haemophilus.
32829873	1	39	theme	purified	119:126	arg1	polysaccharide					194:207	Asparagus cochinchinensis neutral polysaccharide	160:207	Asparagus cochinchinensis neutral polysaccharide	160:207	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	1	39	theme	purified	119:126	arg1	ACNP					154:157	A purified inulin-type fructan named ACNP	117:157	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da	117:250	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	6	40	theme	gut	657:659	arg1	microbiota					661:670	gut microbiota	657:670	gut microbiota	657:670	The results showed that ACNP was digested by gut microbiota, while the pH value in the fecal culture of ACNP was greatly decreased, and total short-chain fatty acids, acetic, propionic, i-valeric and n-valeric acids were significantly increased.
32829873	8	41	theme	dietary	1169:1175	arg1	supplement					1177:1186	a dietary supplement	1167:1186	a dietary supplement	1167:1186	Collectively, these results indicated that ACNP beneficially regulates gut microbiota, which thus suggested that ACNP has the potential to be used as a dietary supplement or drug to improve health.
32829873	4	42	theme	2,1-β-D-Fruf	439:450	arg1	residues					452:459	2,1-β-D-Fruf residues	439:459	2,1-β-D-Fruf residues	439:459	Structural analyses reveal that ACNP has a linear backbone composed of 2,1-β-D-Fruf residues, ending with a (1→2) bonded α-D-Glcp.
32829873	5	43	theme	in	563:564	arg1	fermentation					572:583	in vitro fermentation	563:583	in vitro fermentation with human fecal cultures	563:609	The impacts of ACNP on gut microbiota were then investigated by in vitro fermentation with human fecal cultures.
32829873	1	44	theme	inulin-type	128:138	arg1	polysaccharide					194:207	Asparagus cochinchinensis neutral polysaccharide	160:207	Asparagus cochinchinensis neutral polysaccharide	160:207	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	1	44	theme	inulin-type	128:138	arg1	ACNP					154:157	A purified inulin-type fructan named ACNP	117:157	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da	117:250	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	7	45	theme	fecal	887:891	arg1	composition					904:914	the fecal microbiota composition	883:914	the fecal microbiota composition	883:914	Moreover, ACNP regulated the fecal microbiota composition by stimulating the growth of Prevotella, Megamonas, and Bifidobacterium while depleting Haemophilus.
32829873	1	46	dep	obtained	256:263	arg1	Lour					297:300	Lour	297:300	Lour	297:300	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	6	47	theme	ACNP	716:719	arg1	culture					705:711	the fecal culture	695:711	the fecal culture of ACNP	695:719	The results showed that ACNP was digested by gut microbiota, while the pH value in the fecal culture of ACNP was greatly decreased, and total short-chain fatty acids, acetic, propionic, i-valeric and n-valeric acids were significantly increased.
32829873	1	48	theme	fructan	140:146	arg1	polysaccharide					194:207	Asparagus cochinchinensis neutral polysaccharide	160:207	Asparagus cochinchinensis neutral polysaccharide	160:207	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	1	48	theme	fructan	140:146	arg1	ACNP					154:157	A purified inulin-type fructan named ACNP	117:157	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da	117:250	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	0	49	theme	beneficial	67:76	arg1	impact					78:83	its beneficial impact	63:83	its beneficial impact on human intestinal microbiota	63:114	A novel inulin-type fructan from Asparagus cochinchinensis and its beneficial impact on human intestinal microbiota.
32829873	5	50	theme	gut	522:524	arg1	microbiota					526:535	gut microbiota	522:535	gut microbiota	522:535	The impacts of ACNP on gut microbiota were then investigated by in vitro fermentation with human fecal cultures.
32829873	1	51	theme	named	148:152	arg1	polysaccharide					194:207	Asparagus cochinchinensis neutral polysaccharide	160:207	Asparagus cochinchinensis neutral polysaccharide	160:207	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	1	51	theme	named	148:152	arg1	ACNP					154:157	A purified inulin-type fructan named ACNP	117:157	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da	117:250	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	1	52	theme	Da	249:250	arg1	weight					234:239	apparent molecular weight	215:239	apparent molecular weight of 2690 Da	215:250	A purified inulin-type fructan named ACNP (Asparagus cochinchinensis neutral polysaccharide) with apparent molecular weight of 2690 Da was obtained from Asparagus cochinchinensis (Lour.)
32829873	0	53	from	fructan	20:26	arg1	microbiota					105:114	human intestinal microbiota	88:114	human intestinal microbiota	88:114	A novel inulin-type fructan from Asparagus cochinchinensis and its beneficial impact on human intestinal microbiota.
32829873	5	54	from	impacts	503:509	arg1	microbiota					526:535	gut microbiota	522:535	gut microbiota	522:535	The impacts of ACNP on gut microbiota were then investigated by in vitro fermentation with human fecal cultures.
32829873	4	55	contain	has	405:407	arg2	backbone					418:425	a linear backbone	409:425	a linear backbone composed of 2,1-β-D-Fruf residues	409:459	Structural analyses reveal that ACNP has a linear backbone composed of 2,1-β-D-Fruf residues, ending with a (1→2) bonded α-D-Glcp.
32829873	4	55	contain	has	405:407	arg1	ACNP					400:403	ACNP	400:403	ACNP	400:403	Structural analyses reveal that ACNP has a linear backbone composed of 2,1-β-D-Fruf residues, ending with a (1→2) bonded α-D-Glcp.
33710242	8	0	theme	separation	1145:1154	arg1	kinetics					1156:1163	the phase separation kinetics	1135:1163	the ethanol solvent evaporation rate and thereby the phase separation kinetics	1086:1163	The film thickness was determined by profilometry and it influences the ethanol solvent evaporation rate and thereby the phase separation kinetics.
33710242	4	1	theme	polymer	575:581	arg1	films					583:587	thin uniform polymer films	562:587	thin uniform polymer films	562:587	In this work, spin-coating, a widely applied technique for making thin uniform polymer films, was used to mimic the industrial manufacturing process.
33710242	16	2	theme	spin	2134:2137	arg1	speed					2139:2143	spin speed	2134:2143	spin speed	2134:2143	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	10	3	theme	obtained	1319:1326	arg1	micrographs					1333:1343	The obtained CLSM micrographs	1315:1343	The obtained CLSM micrographs	1315:1343	The obtained CLSM micrographs showed phase separated structures, typical for the spinodal decomposition phase separation mechanism.
33710242	12	4	theme	length	1704:1709	arg1	scale					1711:1715	the characteristic length scale	1685:1715	the characteristic length scale	1685:1715	Varying spin speed and EC : HPC ratio gave us precise control over the characteristic length scale and the thickness of the film.
33710242	11	5	theme	length	1565:1570	arg1	scale					1572:1576	the characteristic length scale	1546:1576	the characteristic length scale of the phase-separated final structure	1546:1615	By using confocal laser scanning microscopy combined with Fourier image analysis, we could extract the characteristic length scale of the phase-separated final structure.
33710242	6	6	theme	laser	813:817	arg1	CLSM					840:843	CLSM	840:843	CLSM	840:843	The structure evolution was determined using confocal laser scanning microscopy (CLSM) and image analysis.
33710242	6	6	theme	laser	813:817	arg1	microscopy					828:837	confocal laser scanning microscopy	804:837	confocal laser scanning microscopy (CLSM)	804:844	The structure evolution was determined using confocal laser scanning microscopy (CLSM) and image analysis.
33710242	17	7	theme	good	2238:2241	arg1	basis					2243:2247	a good basis	2236:2247	a good basis for understanding the mechanisms responsible for the morphology development	2236:2323	These findings give a good basis for understanding the mechanisms responsible for the morphology development and increase the possibilities to tailor thin EC/HPC film structures.
33710242	9	8	theme	1000	1200:1203	arg1	rpm					1216:1218	1000 and 10 000 rpm	1200:1218	rpm	1216:1218	The spin speed was varied between 1000 and 10 000 rpm and the ratio of EC : HPC in the polymer blend was varied between 78 : 22 wt% and 40 : 60 wt%.
33710242	11	9	theme	Fourier	1505:1511	arg1	analysis					1519:1526	Fourier image analysis	1505:1526	Fourier image analysis	1505:1526	By using confocal laser scanning microscopy combined with Fourier image analysis, we could extract the characteristic length scale of the phase-separated final structure.
33710242	17	10	theme	thin	2366:2369	arg1	film					2378:2381	thin EC/HPC film	2366:2381	thin EC/HPC film structures	2366:2392	These findings give a good basis for understanding the mechanisms responsible for the morphology development and increase the possibilities to tailor thin EC/HPC film structures.
33710242	4	11	theme	industrial	612:621	arg1	process					637:643	the industrial manufacturing process	608:643	the industrial manufacturing process	608:643	In this work, spin-coating, a widely applied technique for making thin uniform polymer films, was used to mimic the industrial manufacturing process.
33710242	1	12	theme	drug	227:230	arg1	release					232:238	controlled drug release	216:238	controlled drug release	216:238	Porous phase-separated films made of ethylcellulose (EC) and hydroxypropylcellulose (HPC) are commonly used for controlled drug release.
33710242	17	13	theme	film	2378:2381	arg1	structures					2383:2392	thin EC/HPC film structures	2366:2392	thin EC/HPC film structures	2366:2392	These findings give a good basis for understanding the mechanisms responsible for the morphology development and increase the possibilities to tailor thin EC/HPC film structures.
33710242	4	14	used	used	594:597	arg2	spin-coating					510:521	spin-coating	510:521	spin-coating	510:521	In this work, spin-coating, a widely applied technique for making thin uniform polymer films, was used to mimic the industrial manufacturing process.
33710242	4	14	used	used	594:597	arg2	technique					541:549	a widely applied technique	524:549	a widely applied technique for making thin uniform polymer films	524:587	In this work, spin-coating, a widely applied technique for making thin uniform polymer films, was used to mimic the industrial manufacturing process.
33710242	5	15	theme	work	664:667	arg1	focus					650:654	The focus	646:654	The focus of this work	646:667	The focus of this work was on understanding the structure evolution of phase-separated spin-coated EC/HPC films.
33710242	5	15	theme	work	664:667	arg1	understanding					676:688	understanding	676:688	understanding the structure evolution of phase-separated spin-coated EC/HPC films	676:756	The focus of this work was on understanding the structure evolution of phase-separated spin-coated EC/HPC films.
33710242	9	16	theme	EC 	1237:1239	arg1	ratio					1228:1232	the ratio	1224:1232	the ratio of EC 	1224:1239	The spin speed was varied between 1000 and 10 000 rpm and the ratio of EC : HPC in the polymer blend was varied between 78 : 22 wt% and 40 : 60 wt%.
33710242	9	16	theme	EC 	1237:1239	arg1	rpm					1216:1218	1000 and 10 000 rpm	1200:1218	rpm	1216:1218	The spin speed was varied between 1000 and 10 000 rpm and the ratio of EC : HPC in the polymer blend was varied between 78 : 22 wt% and 40 : 60 wt%.
33710242	13	17	theme	HPC	1861:1863	arg1	ratio					1865:1869	HPC ratio	1861:1869	HPC ratio	1861:1869	The results showed that the characteristic length scale increases with decreasing spin speed and with increasing HPC ratio.
33710242	12	18	theme	precise	1664:1670	arg1	control					1672:1678	us precise control	1661:1678	us precise control	1661:1678	Varying spin speed and EC : HPC ratio gave us precise control over the characteristic length scale and the thickness of the film.
33710242	16	19	theme	%	2194:2194	arg1	compositions					2164:2175	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	16	19	theme	%	2194:2194	arg1	HPC					2196:2198	30 wt% HPC	2189:2198	30 wt% HPC	2189:2198	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	2	20	theme	thin	264:267	arg1	films					269:273	these thin films	258:273	these thin films	258:273	The structure of these thin films is controlling the drug transport from the core to the surrounding liquids in the stomach or intestine.
33710242	7	21	theme	final	962:966	arg1	structure					984:992	the final phase-separated structure	958:992	the final phase-separated structure	958:992	In particular, we determined the influence of spin-coating parameters and EC : HPC ratio on the final phase-separated structure and the film thickness.
33710242	2	22	from	core	318:321	arg1	transport					299:307	the drug transport	290:307	the drug transport from the core to the surrounding liquids in the stomach or intestine	290:376	The structure of these thin films is controlling the drug transport from the core to the surrounding liquids in the stomach or intestine.
33710242	17	23	theme	responsible	2282:2292	arg1	mechanisms					2271:2280	the mechanisms	2267:2280	the mechanisms responsible for the morphology development	2267:2323	These findings give a good basis for understanding the mechanisms responsible for the morphology development and increase the possibilities to tailor thin EC/HPC film structures.
33710242	10	24	theme	typical	1380:1386	arg1	structures					1368:1377	phase separated structures	1352:1377	phase separated structures	1352:1377	The obtained CLSM micrographs showed phase separated structures, typical for the spinodal decomposition phase separation mechanism.
33710242	11	25	theme	laser	1465:1469	arg1	microscopy					1480:1489	confocal laser scanning microscopy	1456:1489	confocal laser scanning microscopy combined with Fourier image analysis	1456:1526	By using confocal laser scanning microscopy combined with Fourier image analysis, we could extract the characteristic length scale of the phase-separated final structure.
33710242	12	26	theme	 HPC	1645:1648	arg1	ratio					1650:1654	 HPC ratio	1645:1654	 HPC ratio	1645:1654	Varying spin speed and EC : HPC ratio gave us precise control over the characteristic length scale and the thickness of the film.
33710242	11	27	theme	scanning	1471:1478	arg1	microscopy					1480:1489	confocal laser scanning microscopy	1456:1489	confocal laser scanning microscopy combined with Fourier image analysis	1456:1526	By using confocal laser scanning microscopy combined with Fourier image analysis, we could extract the characteristic length scale of the phase-separated final structure.
33710242	5	28	theme	phase-separated	717:731	arg1	films					752:756	phase-separated spin-coated EC/HPC films	717:756	phase-separated spin-coated EC/HPC films	717:756	The focus of this work was on understanding the structure evolution of phase-separated spin-coated EC/HPC films.
33710242	7	29	theme	 HPC	944:947	arg1	ratio					949:953	EC : HPC ratio	940:953	EC : HPC ratio	940:953	In particular, we determined the influence of spin-coating parameters and EC : HPC ratio on the final phase-separated structure and the film thickness.
33710242	16	30	theme	wt	2192:2193	arg1	compositions					2164:2175	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	16	30	theme	wt	2192:2193	arg1	HPC					2196:2198	30 wt% HPC	2189:2198	30 wt% HPC	2189:2198	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	12	31	theme	Varying	1618:1624	arg1	speed					1631:1635	Varying spin speed	1618:1635	Varying spin speed	1618:1635	Varying spin speed and EC : HPC ratio gave us precise control over the characteristic length scale and the thickness of the film.
33710242	10	32	theme	decomposition	1405:1417	arg1	mechanism					1436:1444	the spinodal decomposition phase separation mechanism	1392:1444	the spinodal decomposition phase separation mechanism	1392:1444	The obtained CLSM micrographs showed phase separated structures, typical for the spinodal decomposition phase separation mechanism.
33710242	3	33	theme	porous	442:447	arg1	structures					449:458	these porous structures	436:458	these porous structures	436:458	However, detailed understanding of the time evolution of these porous structures as they are formed remains elusive.
33710242	5	34	theme	EC/HPC	745:750	arg1	films					752:756	phase-separated spin-coated EC/HPC films	717:756	phase-separated spin-coated EC/HPC films	717:756	The focus of this work was on understanding the structure evolution of phase-separated spin-coated EC/HPC films.
33710242	9	35	theme	78 	1286:1288	arg1	%					1296:1296	78 : 22 wt%	1286:1296	78 : 22 wt%	1286:1296	The spin speed was varied between 1000 and 10 000 rpm and the ratio of EC : HPC in the polymer blend was varied between 78 : 22 wt% and 40 : 60 wt%.
33710242	16	36	theme	%	2209:2209	arg1	compositions					2164:2175	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	16	36	theme	%	2209:2209	arg1	HPC					2211:2213	45 wt% HPC	2204:2213	45 wt% HPC	2204:2213	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	1	37	theme	phase-separated	111:125	arg1	films					127:131	Porous phase-separated films	104:131	Porous phase-separated films made of ethylcellulose (EC) and hydroxypropylcellulose (HPC)	104:192	Porous phase-separated films made of ethylcellulose (EC) and hydroxypropylcellulose (HPC) are commonly used for controlled drug release.
33710242	3	38	theme	detailed	388:395	arg1	understanding					397:409	detailed understanding	388:409	detailed understanding of the time evolution of these porous structures as they are formed	388:477	However, detailed understanding of the time evolution of these porous structures as they are formed remains elusive.
33710242	0	39	from	separation	33:42	arg1	films					97:101	spin-coated ethylcellulose/hydroxypropylcellulose films	47:101	spin-coated ethylcellulose/hydroxypropylcellulose films	47:101	Structure evolution during phase separation in spin-coated ethylcellulose/hydroxypropylcellulose films.
33710242	16	40	theme	wt	2180:2181	arg1	compositions					2164:2175	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	16	40	theme	wt	2180:2181	arg1	HPC					2184:2186	22 wt% HPC	2177:2186	22 wt% HPC	2177:2186	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	7	41	theme	parameters	925:934	arg1	influence					899:907	the influence	895:907	the influence of spin-coating parameters and EC : HPC ratio on the final phase-separated structure and the film thickness	895:1015	In particular, we determined the influence of spin-coating parameters and EC : HPC ratio on the final phase-separated structure and the film thickness.
33710242	15	42	theme	film	1987:1990	arg1	thickness					1992:2000	film thickness	1987:2000	film thickness	1987:2000	It was found that the relation between film thickness and spin speed followed the Meyerhofer equation with an exponent close to 0.5.
33710242	3	43	theme	time	418:421	arg1	evolution					423:431	the time evolution	414:431	the time evolution of these porous structures	414:458	However, detailed understanding of the time evolution of these porous structures as they are formed remains elusive.
33710242	10	44	theme	separation	1425:1434	arg1	mechanism					1436:1444	the spinodal decomposition phase separation mechanism	1392:1444	the spinodal decomposition phase separation mechanism	1392:1444	The obtained CLSM micrographs showed phase separated structures, typical for the spinodal decomposition phase separation mechanism.
33710242	13	45	theme	length	1791:1796	arg1	scale					1798:1802	the characteristic length scale	1772:1802	the characteristic length scale	1772:1802	The results showed that the characteristic length scale increases with decreasing spin speed and with increasing HPC ratio.
33710242	9	46	theme	40 	1302:1304	arg1	%					1312:1312	40 : 60 wt%	1302:1312	40 : 60 wt%	1302:1312	The spin speed was varied between 1000 and 10 000 rpm and the ratio of EC : HPC in the polymer blend was varied between 78 : 22 wt% and 40 : 60 wt%.
33710242	17	47	theme	morphology	2302:2311	arg1	development					2313:2323	the morphology development	2298:2323	the morphology development	2298:2323	These findings give a good basis for understanding the mechanisms responsible for the morphology development and increase the possibilities to tailor thin EC/HPC film structures.
33710242	0	48	theme	spin-coated	47:57	arg1	films					97:101	spin-coated ethylcellulose/hydroxypropylcellulose films	47:101	spin-coated ethylcellulose/hydroxypropylcellulose films	47:101	Structure evolution during phase separation in spin-coated ethylcellulose/hydroxypropylcellulose films.
33710242	8	49	theme	solvent	1098:1104	arg1	evaporation					1106:1116	the ethanol solvent evaporation	1086:1116	the ethanol solvent evaporation rate and thereby the phase separation kinetics	1086:1163	The film thickness was determined by profilometry and it influences the ethanol solvent evaporation rate and thereby the phase separation kinetics.
33710242	14	50	theme	spin-coated	1893:1903	arg1	film					1905:1908	the spin-coated film	1889:1908	the spin-coated film	1889:1908	The thickness of the spin-coated film decreases with increasing spin speed.
33710242	10	51	theme	phase	1352:1356	arg1	structures					1368:1377	phase separated structures	1352:1377	phase separated structures	1352:1377	The obtained CLSM micrographs showed phase separated structures, typical for the spinodal decomposition phase separation mechanism.
33710242	7	52	theme	spin-coating	912:923	arg1	parameters					925:934	spin-coating parameters	912:934	spin-coating parameters	912:934	In particular, we determined the influence of spin-coating parameters and EC : HPC ratio on the final phase-separated structure and the film thickness.
33710242	13	53	theme	spin	1830:1833	arg1	speed					1835:1839	spin speed	1830:1839	spin speed	1830:1839	The results showed that the characteristic length scale increases with decreasing spin speed and with increasing HPC ratio.
33710242	12	54	theme	film	1742:1745	arg1	scale					1711:1715	the characteristic length scale	1685:1715	the characteristic length scale	1685:1715	Varying spin speed and EC : HPC ratio gave us precise control over the characteristic length scale and the thickness of the film.
33710242	12	54	theme	film	1742:1745	arg1	thickness					1725:1733	the thickness	1721:1733	the thickness of the film	1721:1745	Varying spin speed and EC : HPC ratio gave us precise control over the characteristic length scale and the thickness of the film.
33710242	11	55	theme	structure	1607:1615	arg1	scale					1572:1576	the characteristic length scale	1546:1576	the characteristic length scale of the phase-separated final structure	1546:1615	By using confocal laser scanning microscopy combined with Fourier image analysis, we could extract the characteristic length scale of the phase-separated final structure.
33710242	9	56	theme	spin	1170:1173	arg1	varied					1185:1190	varied	1185:1190	varied	1185:1190	The spin speed was varied between 1000 and 10 000 rpm and the ratio of EC : HPC in the polymer blend was varied between 78 : 22 wt% and 40 : 60 wt%.
33710242	9	56	theme	spin	1170:1173	arg1	speed					1175:1179	The spin speed	1166:1179	The spin speed	1166:1179	The spin speed was varied between 1000 and 10 000 rpm and the ratio of EC : HPC in the polymer blend was varied between 78 : 22 wt% and 40 : 60 wt%.
33710242	8	57	theme	phase	1139:1143	arg1	kinetics					1156:1163	the phase separation kinetics	1135:1163	the ethanol solvent evaporation rate and thereby the phase separation kinetics	1086:1163	The film thickness was determined by profilometry and it influences the ethanol solvent evaporation rate and thereby the phase separation kinetics.
33710242	2	58	from	liquids	342:348	arg1	intestine					368:376	intestine	368:376	intestine	368:376	The structure of these thin films is controlling the drug transport from the core to the surrounding liquids in the stomach or intestine.
33710242	2	58	from	liquids	342:348	arg1	stomach					357:363	stomach	357:363	stomach	357:363	The structure of these thin films is controlling the drug transport from the core to the surrounding liquids in the stomach or intestine.
33710242	4	59	theme	uniform	567:573	arg1	films					583:587	thin uniform polymer films	562:587	thin uniform polymer films	562:587	In this work, spin-coating, a widely applied technique for making thin uniform polymer films, was used to mimic the industrial manufacturing process.
33710242	11	60	theme	phase-separated	1585:1599	arg1	structure					1607:1615	the phase-separated final structure	1581:1615	the phase-separated final structure	1581:1615	By using confocal laser scanning microscopy combined with Fourier image analysis, we could extract the characteristic length scale of the phase-separated final structure.
33710242	6	61	theme	scanning	819:826	arg1	CLSM					840:843	CLSM	840:843	CLSM	840:843	The structure evolution was determined using confocal laser scanning microscopy (CLSM) and image analysis.
33710242	6	61	theme	scanning	819:826	arg1	microscopy					828:837	confocal laser scanning microscopy	804:837	confocal laser scanning microscopy (CLSM)	804:844	The structure evolution was determined using confocal laser scanning microscopy (CLSM) and image analysis.
33710242	6	62	theme	confocal	804:811	arg1	CLSM					840:843	CLSM	840:843	CLSM	840:843	The structure evolution was determined using confocal laser scanning microscopy (CLSM) and image analysis.
33710242	6	62	theme	confocal	804:811	arg1	microscopy					828:837	confocal laser scanning microscopy	804:837	confocal laser scanning microscopy (CLSM)	804:844	The structure evolution was determined using confocal laser scanning microscopy (CLSM) and image analysis.
33710242	2	63	theme	drug	294:297	arg1	transport					299:307	the drug transport	290:307	the drug transport from the core to the surrounding liquids in the stomach or intestine	290:376	The structure of these thin films is controlling the drug transport from the core to the surrounding liquids in the stomach or intestine.
33710242	12	64	theme	characteristic	1689:1702	arg1	scale					1711:1715	the characteristic length scale	1685:1715	the characteristic length scale	1685:1715	Varying spin speed and EC : HPC ratio gave us precise control over the characteristic length scale and the thickness of the film.
33710242	9	65	theme	10 000	1209:1214	arg1	rpm					1216:1218	1000 and 10 000 rpm	1200:1218	rpm	1216:1218	The spin speed was varied between 1000 and 10 000 rpm and the ratio of EC : HPC in the polymer blend was varied between 78 : 22 wt% and 40 : 60 wt%.
33710242	10	66	theme	CLSM	1328:1331	arg1	micrographs					1333:1343	The obtained CLSM micrographs	1315:1343	The obtained CLSM micrographs	1315:1343	The obtained CLSM micrographs showed phase separated structures, typical for the spinodal decomposition phase separation mechanism.
33710242	1	67	theme	controlled	216:225	arg1	release					232:238	controlled drug release	216:238	controlled drug release	216:238	Porous phase-separated films made of ethylcellulose (EC) and hydroxypropylcellulose (HPC) are commonly used for controlled drug release.
33710242	16	68	theme	wt	2207:2208	arg1	compositions					2164:2175	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	16	68	theme	wt	2207:2208	arg1	HPC					2211:2213	45 wt% HPC	2204:2213	45 wt% HPC	2204:2213	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	17	69	theme	EC/HPC	2371:2376	arg1	film					2378:2381	thin EC/HPC film	2366:2381	thin EC/HPC film structures	2366:2392	These findings give a good basis for understanding the mechanisms responsible for the morphology development and increase the possibilities to tailor thin EC/HPC film structures.
33710242	16	70	theme	good	2094:2097	arg1	correlations					2099:2110	good correlations	2094:2110	good correlations between thickness and spin speed	2094:2143	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	5	71	theme	structure	694:702	arg1	evolution					704:712	the structure evolution	690:712	the structure evolution of phase-separated spin-coated EC/HPC films	690:756	The focus of this work was on understanding the structure evolution of phase-separated spin-coated EC/HPC films.
33710242	16	72	dep	compositions	2164:2175	arg1	compositions					2164:2175	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	16	72	dep	compositions	2164:2175	arg1	HPC					2211:2213	45 wt% HPC	2204:2213	45 wt% HPC	2204:2213	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	16	72	dep	compositions	2164:2175	arg1	HPC					2196:2198	30 wt% HPC	2189:2198	30 wt% HPC	2189:2198	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	16	72	dep	compositions	2164:2175	arg1	HPC					2184:2186	22 wt% HPC	2177:2186	22 wt% HPC	2177:2186	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	4	73	theme	manufacturing	623:635	arg1	process					637:643	the industrial manufacturing process	608:643	the industrial manufacturing process	608:643	In this work, spin-coating, a widely applied technique for making thin uniform polymer films, was used to mimic the industrial manufacturing process.
33710242	11	74	theme	image	1513:1517	arg1	analysis					1519:1526	Fourier image analysis	1505:1526	Fourier image analysis	1505:1526	By using confocal laser scanning microscopy combined with Fourier image analysis, we could extract the characteristic length scale of the phase-separated final structure.
33710242	7	75	theme	film	1002:1005	arg1	thickness					1007:1015	the film thickness	998:1015	the film thickness	998:1015	In particular, we determined the influence of spin-coating parameters and EC : HPC ratio on the final phase-separated structure and the film thickness.
33710242	1	76	used	used	207:210	arg2	films					127:131	Porous phase-separated films	104:131	Porous phase-separated films made of ethylcellulose (EC) and hydroxypropylcellulose (HPC)	104:192	Porous phase-separated films made of ethylcellulose (EC) and hydroxypropylcellulose (HPC) are commonly used for controlled drug release.
33710242	5	77	theme	films	752:756	arg1	evolution					704:712	the structure evolution	690:712	the structure evolution of phase-separated spin-coated EC/HPC films	690:756	The focus of this work was on understanding the structure evolution of phase-separated spin-coated EC/HPC films.
33710242	2	78	theme	films	269:273	arg1	structure					245:253	The structure	241:253	The structure of these thin films	241:273	The structure of these thin films is controlling the drug transport from the core to the surrounding liquids in the stomach or intestine.
33710242	11	79	theme	confocal	1456:1463	arg1	microscopy					1480:1489	confocal laser scanning microscopy	1456:1489	confocal laser scanning microscopy combined with Fourier image analysis	1456:1526	By using confocal laser scanning microscopy combined with Fourier image analysis, we could extract the characteristic length scale of the phase-separated final structure.
33710242	9	80	theme	polymer	1253:1259	arg1	blend					1261:1265	the polymer blend	1249:1265	the polymer blend	1249:1265	The spin speed was varied between 1000 and 10 000 rpm and the ratio of EC : HPC in the polymer blend was varied between 78 : 22 wt% and 40 : 60 wt%.
33710242	8	81	theme	film	1022:1025	arg1	thickness					1027:1035	The film thickness	1018:1035	The film thickness	1018:1035	The film thickness was determined by profilometry and it influences the ethanol solvent evaporation rate and thereby the phase separation kinetics.
33710242	7	82	theme	phase-separated	968:982	arg1	structure					984:992	the final phase-separated structure	958:992	the final phase-separated structure	958:992	In particular, we determined the influence of spin-coating parameters and EC : HPC ratio on the final phase-separated structure and the film thickness.
33710242	3	83	dep	understanding	397:409	arg1	formed					472:477	formed	472:477	are formed	468:477	However, detailed understanding of the time evolution of these porous structures as they are formed remains elusive.
33710242	15	84	theme	spin	2006:2009	arg1	speed					2011:2015	spin speed	2006:2015	spin speed	2006:2015	It was found that the relation between film thickness and spin speed followed the Meyerhofer equation with an exponent close to 0.5.
33710242	10	85	theme	separated	1358:1366	arg1	structures					1368:1377	phase separated structures	1352:1377	phase separated structures	1352:1377	The obtained CLSM micrographs showed phase separated structures, typical for the spinodal decomposition phase separation mechanism.
33710242	2	86	dep	stomach	357:363	arg1	the					353:355	the	353:355	the	353:355	The structure of these thin films is controlling the drug transport from the core to the surrounding liquids in the stomach or intestine.
33710242	5	87	theme	spin-coated	733:743	arg1	films					752:756	phase-separated spin-coated EC/HPC films	717:756	phase-separated spin-coated EC/HPC films	717:756	The focus of this work was on understanding the structure evolution of phase-separated spin-coated EC/HPC films.
33710242	7	88	theme	ratio	949:953	arg1	influence					899:907	the influence	895:907	the influence of spin-coating parameters and EC : HPC ratio on the final phase-separated structure and the film thickness	895:1015	In particular, we determined the influence of spin-coating parameters and EC : HPC ratio on the final phase-separated structure and the film thickness.
33710242	1	89	theme	Porous	104:109	arg1	films					127:131	Porous phase-separated films	104:131	Porous phase-separated films made of ethylcellulose (EC) and hydroxypropylcellulose (HPC)	104:192	Porous phase-separated films made of ethylcellulose (EC) and hydroxypropylcellulose (HPC) are commonly used for controlled drug release.
33710242	10	90	theme	spinodal	1396:1403	arg1	mechanism					1436:1444	the spinodal decomposition phase separation mechanism	1392:1444	the spinodal decomposition phase separation mechanism	1392:1444	The obtained CLSM micrographs showed phase separated structures, typical for the spinodal decomposition phase separation mechanism.
33710242	16	91	theme	%	2182:2182	arg1	compositions					2164:2175	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC	2160:2213	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	16	91	theme	%	2182:2182	arg1	HPC					2184:2186	22 wt% HPC	2177:2186	22 wt% HPC	2177:2186	Furthermore, good correlations between thickness and spin speed were found for the compositions 22 wt% HPC, 30 wt% HPC and 45 wt% HPC.
33710242	3	92	theme	structures	449:458	arg1	evolution					423:431	the time evolution	414:431	the time evolution of these porous structures	414:458	However, detailed understanding of the time evolution of these porous structures as they are formed remains elusive.
33710242	12	93	theme	spin	1626:1629	arg1	speed					1631:1635	Varying spin speed	1618:1635	Varying spin speed	1618:1635	Varying spin speed and EC : HPC ratio gave us precise control over the characteristic length scale and the thickness of the film.
33710242	7	94	from	influence	899:907	arg1	structure					984:992	the final phase-separated structure	958:992	the final phase-separated structure	958:992	In particular, we determined the influence of spin-coating parameters and EC : HPC ratio on the final phase-separated structure and the film thickness.
33710242	7	94	from	influence	899:907	arg1	thickness					1007:1015	the film thickness	998:1015	the film thickness	998:1015	In particular, we determined the influence of spin-coating parameters and EC : HPC ratio on the final phase-separated structure and the film thickness.
33710242	0	95	theme	phase	27:31	arg1	separation					33:42	phase separation	27:42	phase separation in spin-coated ethylcellulose/hydroxypropylcellulose films	27:101	Structure evolution during phase separation in spin-coated ethylcellulose/hydroxypropylcellulose films.
33710242	9	96	theme	wt	1294:1295	arg1	%					1296:1296	78 : 22 wt%	1286:1296	78 : 22 wt%	1286:1296	The spin speed was varied between 1000 and 10 000 rpm and the ratio of EC : HPC in the polymer blend was varied between 78 : 22 wt% and 40 : 60 wt%.
33710242	14	97	theme	spin	1936:1939	arg1	speed					1941:1945	spin speed	1936:1945	spin speed	1936:1945	The thickness of the spin-coated film decreases with increasing spin speed.
33710242	4	98	theme	thin	562:565	arg1	films					583:587	thin uniform polymer films	562:587	thin uniform polymer films	562:587	In this work, spin-coating, a widely applied technique for making thin uniform polymer films, was used to mimic the industrial manufacturing process.
33710242	13	99	theme	characteristic	1776:1789	arg1	scale					1798:1802	the characteristic length scale	1772:1802	the characteristic length scale	1772:1802	The results showed that the characteristic length scale increases with decreasing spin speed and with increasing HPC ratio.
33710242	8	100	theme	ethanol	1090:1096	arg1	evaporation					1106:1116	the ethanol solvent evaporation	1086:1116	the ethanol solvent evaporation rate and thereby the phase separation kinetics	1086:1163	The film thickness was determined by profilometry and it influences the ethanol solvent evaporation rate and thereby the phase separation kinetics.
33710242	3	101	theme	evolution	423:431	arg1	understanding					397:409	detailed understanding	388:409	detailed understanding of the time evolution of these porous structures as they are formed	388:477	However, detailed understanding of the time evolution of these porous structures as they are formed remains elusive.
33710242	10	102	theme	phase	1419:1423	arg1	mechanism					1436:1444	the spinodal decomposition phase separation mechanism	1392:1444	the spinodal decomposition phase separation mechanism	1392:1444	The obtained CLSM micrographs showed phase separated structures, typical for the spinodal decomposition phase separation mechanism.
33710242	6	103	theme	structure	763:771	arg1	evolution					773:781	The structure evolution	759:781	The structure evolution	759:781	The structure evolution was determined using confocal laser scanning microscopy (CLSM) and image analysis.
33710242	0	104	theme	ethylcellulose/hydroxypropylcellulose	59:95	arg1	films					97:101	spin-coated ethylcellulose/hydroxypropylcellulose films	47:101	spin-coated ethylcellulose/hydroxypropylcellulose films	47:101	Structure evolution during phase separation in spin-coated ethylcellulose/hydroxypropylcellulose films.
33710242	8	105	theme	evaporation	1106:1116	arg1	rate					1118:1121	the ethanol solvent evaporation rate	1086:1121	the ethanol solvent evaporation rate and thereby the phase separation kinetics	1086:1163	The film thickness was determined by profilometry and it influences the ethanol solvent evaporation rate and thereby the phase separation kinetics.
33710242	6	106	theme	image	850:854	arg1	analysis					856:863	image analysis	850:863	image analysis	850:863	The structure evolution was determined using confocal laser scanning microscopy (CLSM) and image analysis.
33710242	14	107	theme	film	1905:1908	arg1	thickness					1876:1884	The thickness	1872:1884	The thickness of the spin-coated film	1872:1908	The thickness of the spin-coated film decreases with increasing spin speed.
33710242	4	108	theme	applied	533:539	arg1	technique					541:549	a widely applied technique	524:549	a widely applied technique for making thin uniform polymer films	524:587	In this work, spin-coating, a widely applied technique for making thin uniform polymer films, was used to mimic the industrial manufacturing process.
33710242	4	108	theme	applied	533:539	arg1	spin-coating					510:521	spin-coating	510:521	spin-coating	510:521	In this work, spin-coating, a widely applied technique for making thin uniform polymer films, was used to mimic the industrial manufacturing process.
33710242	9	109	theme	wt	1310:1311	arg1	%					1312:1312	40 : 60 wt%	1302:1312	40 : 60 wt%	1302:1312	The spin speed was varied between 1000 and 10 000 rpm and the ratio of EC : HPC in the polymer blend was varied between 78 : 22 wt% and 40 : 60 wt%.
33710242	15	110	theme	Meyerhofer	2030:2039	arg1	equation					2041:2048	the Meyerhofer equation	2026:2048	the Meyerhofer equation	2026:2048	It was found that the relation between film thickness and spin speed followed the Meyerhofer equation with an exponent close to 0.5.
33710242	13	111	dep	increases	1804:1812	arg1	increasing					1850:1859	increasing	1850:1859	increasing HPC ratio	1850:1869	The results showed that the characteristic length scale increases with decreasing spin speed and with increasing HPC ratio.
33710242	13	111	dep	increases	1804:1812	arg1	decreasing					1819:1828	decreasing	1819:1828	decreasing spin speed	1819:1839	The results showed that the characteristic length scale increases with decreasing spin speed and with increasing HPC ratio.
33710242	12	112	dep	speed	1631:1635	arg1	gave					1656:1659	gave	1656:1659	gave us precise control over the characteristic length scale and the thickness of the film	1656:1745	Varying spin speed and EC : HPC ratio gave us precise control over the characteristic length scale and the thickness of the film.
33710242	2	113	theme	surrounding	330:340	arg1	liquids					342:348	the surrounding liquids	326:348	the surrounding liquids in the stomach or intestine	326:376	The structure of these thin films is controlling the drug transport from the core to the surrounding liquids in the stomach or intestine.
33710242	9	114	from	 HPC	1241:1244	arg1	blend					1261:1265	the polymer blend	1249:1265	the polymer blend	1249:1265	The spin speed was varied between 1000 and 10 000 rpm and the ratio of EC : HPC in the polymer blend was varied between 78 : 22 wt% and 40 : 60 wt%.
33710242	11	115	theme	final	1601:1605	arg1	structure					1607:1615	the phase-separated final structure	1581:1615	the phase-separated final structure	1581:1615	By using confocal laser scanning microscopy combined with Fourier image analysis, we could extract the characteristic length scale of the phase-separated final structure.
33710242	11	116	theme	characteristic	1550:1563	arg1	scale					1572:1576	the characteristic length scale	1546:1576	the characteristic length scale of the phase-separated final structure	1546:1615	By using confocal laser scanning microscopy combined with Fourier image analysis, we could extract the characteristic length scale of the phase-separated final structure.
32474786	7	0	theme	adsorption	1410:1419	arg1	amount					1421:1426	the maximum adsorption amount	1398:1426	the maximum adsorption amount of dichromate ions on the β-CD/MGO	1398:1461	Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g-1.
32474786	7	0	theme	adsorption	1410:1419	arg1	ions					1442:1445	dichromate ions	1431:1445	dichromate ions	1431:1445	Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g-1.
32474786	7	0	theme	adsorption	1410:1419	arg1	49.95 mg g-1					1467:1478	49.95 mg g-1	1467:1478	49.95 mg g-1	1467:1478	Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g-1.
32474786	8	1	theme	adsorbent	1609:1617	arg1	reusability					1585:1595	the excellent potential reusability	1561:1595	the excellent potential reusability of β-CD/MGO adsorbent	1561:1617	After five successive adsorbent reuses, the reuse rate is still 73%, indicating the excellent potential reusability of β-CD/MGO adsorbent.
32474786	4	2	theme	surface	1050:1056	arg1	area					1058:1061	a specific surface area	1039:1061	a specific surface area of 252.3 m2g-1	1039:1076	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	1	3	theme	vibrating	436:444	arg1	VSM					467:469	VSM	467:469	VSM	467:469	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	1	3	theme	vibrating	436:444	arg1	magnetometer					453:464	vibrating sample magnetometer	436:464	vibrating sample magnetometer (VSM)	436:470	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	3	4	theme	graphene	693:700	arg1	oxide					702:706	graphene oxide	693:706	the graphene oxide (GO) layer	689:717	The results from SEM and TEM showed that the graphene oxide (GO) layer became rough, and many fine particles were attached after compounding with ferroferric oxide and β-cyclodextrin.
32474786	10	5	theme	magnetic	1723:1730	arg1	friendly					1714:1721	an environmentally friendly magnetic adsorbent	1695:1740	an environmentally friendly magnetic adsorbent	1695:1740	As an environmentally friendly magnetic adsorbent, β-CD/MGO is suitable for the treatment of dichromate-containing wastewater.
32474786	4	6	theme	FT-IR	864:868	arg1	results					853:859	The characterization results	832:859	The characterization results of FT-IR and XPS	832:876	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	4	7	theme	460 nm	1031:1036	arg1	area					1058:1061	a specific surface area	1039:1061	a specific surface area of 252.3 m2g-1	1039:1076	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	4	7	theme	460 nm	1031:1036	arg1	size					1017:1020	a particle size	1006:1020	a particle size of about 460 nm	1006:1036	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	4	7	theme	460 nm	1031:1036	arg1	magnetization					1096:1108	a saturation magnetization	1083:1108	a saturation magnetization of 73.5 emu g-1	1083:1124	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	6	8	theme	Kinetic	1242:1248	arg1	studies					1250:1256	Kinetic studies	1242:1256	Kinetic studies	1242:1256	Kinetic studies showed that the adsorption process followed a pseudo-second-order kinetic model.
32474786	10	9	theme	environmentally	1698:1712	arg1	friendly					1714:1721	an environmentally friendly magnetic adsorbent	1695:1740	an environmentally friendly magnetic adsorbent	1695:1740	As an environmentally friendly magnetic adsorbent, β-CD/MGO is suitable for the treatment of dichromate-containing wastewater.
32474786	4	10	theme	XPS	874:876	arg1	results					853:859	The characterization results	832:859	The characterization results of FT-IR and XPS	832:876	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	9	11	theme	adsorption	1648:1657	arg1	performance					1659:1669	excellent adsorption performance	1638:1669	excellent adsorption performance for dichromate ions	1638:1689	β-CD/MGO exhibits excellent adsorption performance for dichromate ions.
32474786	1	12	dep	in	218:219	arg1	situ					221:224	situ	221:224	situ	221:224	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	4	13	theme	saturation	1085:1094	arg1	magnetization					1096:1108	a saturation magnetization	1083:1108	a saturation magnetization of 73.5 emu g-1	1083:1124	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	2	14	theme	ions	539:542	arg1	behavior					516:523	The adsorption behavior	501:523	The adsorption behavior of dichromate ions on the β-CD/MGO	501:558	The adsorption behavior of dichromate ions on the β-CD/MGO was investigated, and the mechanism of adsorption was also studied using FT-IR and XPS.
32474786	1	15	theme	photoelectron	402:414	arg1	XPS					430:432	XPS	430:432	XPS	430:432	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	1	15	theme	photoelectron	402:414	arg1	spectroscopy					416:427	X-ray photoelectron spectroscopy	396:427	X-ray photoelectron spectroscopy (XPS)	396:433	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	4	16	theme	ferroferric	912:922	arg1	oxide					924:928	ferroferric oxide	912:928	ferroferric oxide	912:928	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	4	17	theme	m2g-1	1072:1076	arg1	area					1058:1061	a specific surface area	1039:1061	a specific surface area of 252.3 m2g-1	1039:1076	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	4	17	theme	m2g-1	1072:1076	arg1	size					1017:1020	a particle size	1006:1020	a particle size of about 460 nm	1006:1036	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	4	17	theme	m2g-1	1072:1076	arg1	magnetization					1096:1108	a saturation magnetization	1083:1108	a saturation magnetization of 73.5 emu g-1	1083:1124	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	5	18	theme	adsorbent	1203:1211	arg1	dosage					1213:1218	adsorbent dosage	1203:1218	adsorbent dosage	1203:1218	The adsorption amount of dichromate ions on the β-CD/MGO is affected by pH, adsorbent dosage, and adsorption time.
32474786	0	19	theme	magnetic	57:64	arg1	oxide					75:79	magnetic graphene oxide	57:79	magnetic graphene oxide	57:79	Adsorption of dichromate ions from aqueous solution onto magnetic graphene oxide modified by β-cyclodextrin.
32474786	1	20	theme	electron	329:336	arg1	SEM					350:352	SEM	350:352	SEM	350:352	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	1	20	theme	electron	329:336	arg1	microscopy					338:347	scanning electron microscopy	320:347	scanning electron microscopy (SEM)	320:353	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	1	21	theme	modified	142:149	arg1	composite					186:194	the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite	123:194	the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite	123:194	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	9	22	theme	dichromate	1675:1684	arg1	ions					1686:1689	dichromate ions	1675:1689	dichromate ions	1675:1689	β-CD/MGO exhibits excellent adsorption performance for dichromate ions.
32474786	1	23	theme	graphene	160:167	arg1	composite					186:194	the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite	123:194	the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite	123:194	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	3	24	theme	ferroferric	794:804	arg1	oxide					806:810	ferroferric oxide	794:810	ferroferric oxide	794:810	The results from SEM and TEM showed that the graphene oxide (GO) layer became rough, and many fine particles were attached after compounding with ferroferric oxide and β-cyclodextrin.
32474786	3	25	theme	many	737:740	arg1	particles					747:755	many fine particles	737:755	many fine particles	737:755	The results from SEM and TEM showed that the graphene oxide (GO) layer became rough, and many fine particles were attached after compounding with ferroferric oxide and β-cyclodextrin.
32474786	0	26	from	solution	43:50	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of dichromate ions from aqueous solution onto magnetic graphene oxide	0:79	Adsorption of dichromate ions from aqueous solution onto magnetic graphene oxide modified by β-cyclodextrin.
32474786	2	27	theme	adsorption	599:608	arg1	mechanism					586:594	the mechanism	582:594	the mechanism of adsorption	582:608	The adsorption behavior of dichromate ions on the β-CD/MGO was investigated, and the mechanism of adsorption was also studied using FT-IR and XPS.
32474786	1	28	theme	transmission	356:367	arg1	TEM					390:392	TEM	390:392	TEM	390:392	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	1	28	theme	transmission	356:367	arg1	microscopy					378:387	transmission electron microscopy	356:387	transmission electron microscopy (TEM)	356:393	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	4	29	theme	graphene	968:975	arg1	layer					983:987	the graphene oxide layer	964:987	the graphene oxide layer	964:987	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	0	30	theme	graphene	66:73	arg1	oxide					75:79	magnetic graphene oxide	57:79	magnetic graphene oxide	57:79	Adsorption of dichromate ions from aqueous solution onto magnetic graphene oxide modified by β-cyclodextrin.
32474786	1	31	theme	Fourier	271:277	arg1	spectroscopy					298:309	Fourier transform-infrared spectroscopy	271:309	Fourier transform-infrared spectroscopy (FT-IR)	271:317	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	1	31	theme	Fourier	271:277	arg1	FT-IR					312:316	FT-IR	312:316	FT-IR	312:316	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	0	32	theme	dichromate	14:23	arg1	ions					25:28	dichromate ions	14:28	dichromate ions	14:28	Adsorption of dichromate ions from aqueous solution onto magnetic graphene oxide modified by β-cyclodextrin.
32474786	5	33	theme	adsorption	1225:1234	arg1	time					1236:1239	adsorption time	1225:1239	adsorption time	1225:1239	The adsorption amount of dichromate ions on the β-CD/MGO is affected by pH, adsorbent dosage, and adsorption time.
32474786	8	34	theme	successive	1492:1501	arg1	reuses					1513:1518	five successive adsorbent reuses	1487:1518	five successive adsorbent reuses	1487:1518	After five successive adsorbent reuses, the reuse rate is still 73%, indicating the excellent potential reusability of β-CD/MGO adsorbent.
32474786	10	35	theme	dichromate-containing	1785:1805	arg1	wastewater					1807:1816	dichromate-containing wastewater	1785:1816	dichromate-containing wastewater	1785:1816	As an environmentally friendly magnetic adsorbent, β-CD/MGO is suitable for the treatment of dichromate-containing wastewater.
32474786	6	36	theme	kinetic	1324:1330	arg1	model					1332:1336	a pseudo-second-order kinetic model	1302:1336	a pseudo-second-order kinetic model	1302:1336	Kinetic studies showed that the adsorption process followed a pseudo-second-order kinetic model.
32474786	7	37	theme	dichromate	1431:1440	arg1	ions					1442:1445	dichromate ions	1431:1445	dichromate ions	1431:1445	Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g-1.
32474786	1	38	theme	size	486:489	arg1	analysis					491:498	particle size analysis	477:498	particle size analysis	477:498	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	8	39	theme	excellent	1565:1573	arg1	reusability					1585:1595	the excellent potential reusability	1561:1595	the excellent potential reusability of β-CD/MGO adsorbent	1561:1617	After five successive adsorbent reuses, the reuse rate is still 73%, indicating the excellent potential reusability of β-CD/MGO adsorbent.
32474786	5	40	theme	ions	1163:1166	arg1	amount					1142:1147	The adsorption amount	1127:1147	The adsorption amount of dichromate ions on the β-CD/MGO	1127:1182	The adsorption amount of dichromate ions on the β-CD/MGO is affected by pH, adsorbent dosage, and adsorption time.
32474786	5	40	theme	ions	1163:1166	arg1	ions					1163:1166	dichromate ions	1152:1166	dichromate ions	1152:1166	The adsorption amount of dichromate ions on the β-CD/MGO is affected by pH, adsorbent dosage, and adsorption time.
32474786	7	41	theme	maximum	1402:1408	arg1	amount					1421:1426	the maximum adsorption amount	1398:1426	the maximum adsorption amount of dichromate ions on the β-CD/MGO	1398:1461	Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g-1.
32474786	7	41	theme	maximum	1402:1408	arg1	ions					1442:1445	dichromate ions	1431:1445	dichromate ions	1431:1445	Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g-1.
32474786	7	41	theme	maximum	1402:1408	arg1	49.95 mg g-1					1467:1478	49.95 mg g-1	1467:1478	49.95 mg g-1	1467:1478	Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g-1.
32474786	2	42	from	behavior	516:523	arg1	β-CD/MGO					551:558	the β-CD/MGO	547:558	the β-CD/MGO	547:558	The adsorption behavior of dichromate ions on the β-CD/MGO was investigated, and the mechanism of adsorption was also studied using FT-IR and XPS.
32474786	5	43	theme	adsorption	1131:1140	arg1	amount					1142:1147	The adsorption amount	1127:1147	The adsorption amount of dichromate ions on the β-CD/MGO	1127:1182	The adsorption amount of dichromate ions on the β-CD/MGO is affected by pH, adsorbent dosage, and adsorption time.
32474786	5	43	theme	adsorption	1131:1140	arg1	ions					1163:1166	dichromate ions	1152:1166	dichromate ions	1152:1166	The adsorption amount of dichromate ions on the β-CD/MGO is affected by pH, adsorbent dosage, and adsorption time.
32474786	7	44	theme	Langmuir	1382:1389	arg1	model					1391:1395	the Langmuir model	1378:1395	the Langmuir model	1378:1395	Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g-1.
32474786	1	45	theme	oxide	169:173	arg1	composite					186:194	the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite	123:194	the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite	123:194	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	3	46	from	SEM	665:667	arg1	results					652:658	The results	648:658	The results from SEM and TEM	648:675	The results from SEM and TEM showed that the graphene oxide (GO) layer became rough, and many fine particles were attached after compounding with ferroferric oxide and β-cyclodextrin.
32474786	1	47	theme	sample	446:451	arg1	VSM					467:469	VSM	467:469	VSM	467:469	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	1	47	theme	sample	446:451	arg1	magnetometer					453:464	vibrating sample magnetometer	436:464	vibrating sample magnetometer (VSM)	436:470	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	10	48	theme	adsorbent	1732:1740	arg1	friendly					1714:1721	an environmentally friendly magnetic adsorbent	1695:1740	an environmentally friendly magnetic adsorbent	1695:1740	As an environmentally friendly magnetic adsorbent, β-CD/MGO is suitable for the treatment of dichromate-containing wastewater.
32474786	1	49	theme	β-CD/MGO	176:183	arg1	composite					186:194	the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite	123:194	the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite	123:194	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	7	50	theme	Equilibrium	1339:1349	arg1	data					1351:1354	Equilibrium data	1339:1354	Equilibrium data	1339:1354	Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g-1.
32474786	3	51	from	TEM	673:675	arg1	results					652:658	The results	648:658	The results from SEM and TEM	648:675	The results from SEM and TEM showed that the graphene oxide (GO) layer became rough, and many fine particles were attached after compounding with ferroferric oxide and β-cyclodextrin.
32474786	3	52	theme	oxide	702:706	arg1	layer					713:717	the graphene oxide (GO) layer	689:717	the graphene oxide (GO) layer	689:717	The results from SEM and TEM showed that the graphene oxide (GO) layer became rough, and many fine particles were attached after compounding with ferroferric oxide and β-cyclodextrin.
32474786	2	53	theme	dichromate	528:537	arg1	ions					539:542	dichromate ions	528:542	dichromate ions	528:542	The adsorption behavior of dichromate ions on the β-CD/MGO was investigated, and the mechanism of adsorption was also studied using FT-IR and XPS.
32474786	4	54	theme	specific	1041:1048	arg1	area					1058:1061	a specific surface area	1039:1061	a specific surface area of 252.3 m2g-1	1039:1076	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	9	55	theme	excellent	1638:1646	arg1	performance					1659:1669	excellent adsorption performance	1638:1669	excellent adsorption performance for dichromate ions	1638:1689	β-CD/MGO exhibits excellent adsorption performance for dichromate ions.
32474786	4	56	theme	73.5 emu g-1	1113:1124	arg1	area					1058:1061	a specific surface area	1039:1061	a specific surface area of 252.3 m2g-1	1039:1076	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	4	56	theme	73.5 emu g-1	1113:1124	arg1	size					1017:1020	a particle size	1006:1020	a particle size of about 460 nm	1006:1036	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	4	56	theme	73.5 emu g-1	1113:1124	arg1	magnetization					1096:1108	a saturation magnetization	1083:1108	a saturation magnetization of 73.5 emu g-1	1083:1124	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	1	57	theme	X-ray	396:400	arg1	XPS					430:432	XPS	430:432	XPS	430:432	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	1	57	theme	X-ray	396:400	arg1	spectroscopy					416:427	X-ray photoelectron spectroscopy	396:427	X-ray photoelectron spectroscopy (XPS)	396:433	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	4	58	theme	characterization	836:851	arg1	results					853:859	The characterization results	832:859	The characterization results of FT-IR and XPS	832:876	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	6	59	theme	pseudo-second-order	1304:1322	arg1	model					1332:1336	a pseudo-second-order kinetic model	1302:1336	a pseudo-second-order kinetic model	1302:1336	Kinetic studies showed that the adsorption process followed a pseudo-second-order kinetic model.
32474786	1	60	theme	β-cyclodextrin	127:140	arg1	composite					186:194	the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite	123:194	the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite	123:194	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	4	61	contain	has	1002:1004	arg2	size					1017:1020	a particle size	1006:1020	a particle size of about 460 nm	1006:1036	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	4	61	contain	has	1002:1004	arg2	area					1058:1061	a specific surface area	1039:1061	a specific surface area of 252.3 m2g-1	1039:1076	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	4	61	contain	has	1002:1004	arg2	magnetization					1096:1108	a saturation magnetization	1083:1108	a saturation magnetization of 73.5 emu g-1	1083:1124	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	4	61	contain	has	1002:1004	arg1	β-CD/MGO					993:1000	β-CD/MGO	993:1000	β-CD/MGO	993:1000	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	1	62	theme	magnetic	151:158	arg1	composite					186:194	the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite	123:194	the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite	123:194	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	5	63	from	amount	1142:1147	arg1	β-CD/MGO					1175:1182	the β-CD/MGO	1171:1182	the β-CD/MGO	1171:1182	The adsorption amount of dichromate ions on the β-CD/MGO is affected by pH, adsorbent dosage, and adsorption time.
32474786	6	64	theme	adsorption	1274:1283	arg1	process					1285:1291	the adsorption process	1270:1291	the adsorption process	1270:1291	Kinetic studies showed that the adsorption process followed a pseudo-second-order kinetic model.
32474786	3	65	dep	oxide	702:706	arg1	GO					709:710	GO	709:710	GO	709:710	The results from SEM and TEM showed that the graphene oxide (GO) layer became rough, and many fine particles were attached after compounding with ferroferric oxide and β-cyclodextrin.
32474786	3	66	theme	fine	742:745	arg1	particles					747:755	many fine particles	737:755	many fine particles	737:755	The results from SEM and TEM showed that the graphene oxide (GO) layer became rough, and many fine particles were attached after compounding with ferroferric oxide and β-cyclodextrin.
32474786	1	67	theme	in	218:219	arg1	method					243:248	the in situ co-precipitation method	214:248	the in situ co-precipitation method	214:248	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	1	68	theme	electron	369:376	arg1	TEM					390:392	TEM	390:392	TEM	390:392	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	1	68	theme	electron	369:376	arg1	microscopy					378:387	transmission electron microscopy	356:387	transmission electron microscopy (TEM)	356:393	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	2	69	theme	adsorption	505:514	arg1	behavior					516:523	The adsorption behavior	501:523	The adsorption behavior of dichromate ions on the β-CD/MGO	501:558	The adsorption behavior of dichromate ions on the β-CD/MGO was investigated, and the mechanism of adsorption was also studied using FT-IR and XPS.
32474786	0	70	theme	ions	25:28	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of dichromate ions from aqueous solution onto magnetic graphene oxide	0:79	Adsorption of dichromate ions from aqueous solution onto magnetic graphene oxide modified by β-cyclodextrin.
32474786	1	71	theme	transform-infrared	279:296	arg1	spectroscopy					298:309	Fourier transform-infrared spectroscopy	271:309	Fourier transform-infrared spectroscopy (FT-IR)	271:317	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	1	71	theme	transform-infrared	279:296	arg1	FT-IR					312:316	FT-IR	312:316	FT-IR	312:316	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	4	72	theme	oxide	977:981	arg1	layer					983:987	the graphene oxide layer	964:987	the graphene oxide layer	964:987	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	0	73	theme	aqueous	35:41	arg1	solution					43:50	aqueous solution	35:50	aqueous solution	35:50	Adsorption of dichromate ions from aqueous solution onto magnetic graphene oxide modified by β-cyclodextrin.
32474786	8	74	theme	adsorbent	1503:1511	arg1	reuses					1513:1518	five successive adsorbent reuses	1487:1518	five successive adsorbent reuses	1487:1518	After five successive adsorbent reuses, the reuse rate is still 73%, indicating the excellent potential reusability of β-CD/MGO adsorbent.
32474786	10	75	theme	wastewater	1807:1816	arg1	treatment					1772:1780	the treatment	1768:1780	the treatment of dichromate-containing wastewater	1768:1816	As an environmentally friendly magnetic adsorbent, β-CD/MGO is suitable for the treatment of dichromate-containing wastewater.
32474786	3	76	with	compounding	777:787	arg1	oxide					806:810	ferroferric oxide	794:810	ferroferric oxide	794:810	The results from SEM and TEM showed that the graphene oxide (GO) layer became rough, and many fine particles were attached after compounding with ferroferric oxide and β-cyclodextrin.
32474786	3	76	with	compounding	777:787	arg1	β-cyclodextrin					816:829	β-cyclodextrin	816:829	β-cyclodextrin	816:829	The results from SEM and TEM showed that the graphene oxide (GO) layer became rough, and many fine particles were attached after compounding with ferroferric oxide and β-cyclodextrin.
32474786	1	77	theme	scanning	320:327	arg1	SEM					350:352	SEM	350:352	SEM	350:352	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	1	77	theme	scanning	320:327	arg1	microscopy					338:347	scanning electron microscopy	320:347	scanning electron microscopy (SEM)	320:353	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	7	78	theme	ions	1442:1445	arg1	amount					1421:1426	the maximum adsorption amount	1398:1426	the maximum adsorption amount of dichromate ions on the β-CD/MGO	1398:1461	Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g-1.
32474786	7	78	theme	ions	1442:1445	arg1	ions					1442:1445	dichromate ions	1431:1445	dichromate ions	1431:1445	Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g-1.
32474786	7	78	theme	ions	1442:1445	arg1	49.95 mg g-1					1467:1478	49.95 mg g-1	1467:1478	49.95 mg g-1	1467:1478	Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g-1.
32474786	4	79	theme	particle	1008:1015	arg1	size					1017:1020	a particle size	1006:1020	a particle size of about 460 nm	1006:1036	The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m2g-1, and a saturation magnetization of 73.5 emu g-1.
32474786	8	80	theme	reuse	1525:1529	arg1	rate					1531:1534	the reuse rate	1521:1534	the reuse rate	1521:1534	After five successive adsorbent reuses, the reuse rate is still 73%, indicating the excellent potential reusability of β-CD/MGO adsorbent.
32474786	8	80	theme	reuse	1525:1529	arg1	%					1547:1547	73%	1545:1547	73%	1545:1547	After five successive adsorbent reuses, the reuse rate is still 73%, indicating the excellent potential reusability of β-CD/MGO adsorbent.
32474786	1	81	theme	particle	477:484	arg1	analysis					491:498	particle size analysis	477:498	particle size analysis	477:498	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32474786	8	82	theme	potential	1575:1583	arg1	reusability					1585:1595	the excellent potential reusability	1561:1595	the excellent potential reusability of β-CD/MGO adsorbent	1561:1617	After five successive adsorbent reuses, the reuse rate is still 73%, indicating the excellent potential reusability of β-CD/MGO adsorbent.
32474786	5	83	theme	dichromate	1152:1161	arg1	ions					1163:1166	dichromate ions	1152:1166	dichromate ions	1152:1166	The adsorption amount of dichromate ions on the β-CD/MGO is affected by pH, adsorbent dosage, and adsorption time.
32474786	7	84	from	amount	1421:1426	arg1	β-CD/MGO					1454:1461	the β-CD/MGO	1450:1461	the β-CD/MGO	1450:1461	Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g-1.
32474786	1	85	theme	co-precipitation	226:241	arg1	method					243:248	the in situ co-precipitation method	214:248	the in situ co-precipitation method	214:248	In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis.
32205109	5	0	from	release	849:855	arg1	media					900:904	different media	890:904	different media	890:904	The release of doxycycline form hydrogels in different media obeyed the mechanism of non-Fickian diffusion and best fitted to the Higuchi model and Korsmeyer-Peppas.
32205109	4	1	theme	drug	764:767	arg1	loading					769:775	drug loading	764:775	drug loading	764:775	The effect of the dose of electron beam irradiation and PAAm amount on the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content were studied.
32205109	0	2	theme	caffeic	86:92	arg1	acid					94:97	caffeic acid	86:97	caffeic acid	86:97	Doxycycline drug delivery using hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide synthesized by electron beam irradiation.
32205109	0	3	with	acid	94:97	arg1	polyacrylamide					122:135	polyacrylamide	122:135	polyacrylamide synthesized by electron beam irradiation	122:176	Doxycycline drug delivery using hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide synthesized by electron beam irradiation.
32205109	6	4	from	hydrogel	1103:1110	arg1	release					1080:1086	the drug's release	1069:1086	the drug's release from composite hydrogel	1069:1110	In-vitro doxycycline release consideration indicated that the drug's release from composite hydrogel occurs with higher amounts than the other one.
32205109	2	5	dep	spectroscopy	413:424	arg1	studies					530:536	studies	530:536	studies	530:536	The synthesized hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and mechanical properties studies.
32205109	4	6	theme	dose	663:666	arg1	effect					649:654	The effect	645:654	The effect of the dose of electron beam irradiation and PAAm amount on the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content	645:829	The effect of the dose of electron beam irradiation and PAAm amount on the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content were studied.
32205109	9	7	theme	synthesized	1404:1414	arg1	hydrogels					1416:1424	the synthesized hydrogels	1400:1424	the synthesized hydrogels	1400:1424	So, the synthesized hydrogels are appropriate for practical application as a new antibacterial wound dressing.
32205109	9	7	theme	synthesized	1404:1414	arg1	appropriate					1430:1440	appropriate	1430:1440	appropriate	1430:1440	So, the synthesized hydrogels are appropriate for practical application as a new antibacterial wound dressing.
32205109	3	8	theme	various	630:636	arg1	media					638:642	various media	630:642	various media	630:642	The hydrogels were loaded with doxycycline by swelling and its release was investigated in various media.
32205109	9	9	theme	new	1473:1475	arg1	dressing					1497:1504	a new antibacterial wound dressing	1471:1504	a new antibacterial wound dressing	1471:1504	So, the synthesized hydrogels are appropriate for practical application as a new antibacterial wound dressing.
32205109	7	10	theme	cytotoxic	1163:1171	arg1	study					1173:1177	The cytotoxic study	1159:1177	The cytotoxic study	1159:1177	The cytotoxic study confirmed the non-toxicity of the prepared hydrogels dressing.
32205109	5	11	theme	different	890:898	arg1	media					900:904	different media	890:904	different media	890:904	The release of doxycycline form hydrogels in different media obeyed the mechanism of non-Fickian diffusion and best fitted to the Higuchi model and Korsmeyer-Peppas.
32205109	4	12	theme	hydrogels	734:742	arg1	properties					720:729	the properties	716:729	the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content	716:829	The effect of the dose of electron beam irradiation and PAAm amount on the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content were studied.
32205109	6	13	theme	higher	1124:1129	arg1	amounts					1131:1137	higher amounts	1124:1137	higher amounts than the other one	1124:1156	In-vitro doxycycline release consideration indicated that the drug's release from composite hydrogel occurs with higher amounts than the other one.
32205109	4	14	from	effect	649:654	arg1	properties					720:729	the properties	716:729	the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content	716:829	The effect of the dose of electron beam irradiation and PAAm amount on the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content were studied.
32205109	0	15	theme	Doxycycline	0:10	arg1	delivery					17:24	Doxycycline drug delivery	0:24	Doxycycline drug delivery using hydrogels of O-carboxymethyl chitosan	0:68	Doxycycline drug delivery using hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide synthesized by electron beam irradiation.
32205109	2	16	theme	thermogravimetric	446:462	arg1	analysis					464:471	thermogravimetric analysis	446:471	thermogravimetric analysis	446:471	The synthesized hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and mechanical properties studies.
32205109	0	17	theme	drug	12:15	arg1	delivery					17:24	Doxycycline drug delivery	0:24	Doxycycline drug delivery using hydrogels of O-carboxymethyl chitosan	0:68	Doxycycline drug delivery using hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide synthesized by electron beam irradiation.
32205109	8	18	theme	growth	1256:1261	arg1	inhibition					1263:1272	the growth inhibition	1252:1272	the growth inhibition of permissive bacteria against Staphylococcus aureus and Escherichia coli	1252:1346	Moreover, the growth inhibition of permissive bacteria against Staphylococcus aureus and Escherichia coli were observed for doxycycline-loaded hydrogels.
32205109	0	19	with	composite	107:115	arg1	polyacrylamide					122:135	polyacrylamide	122:135	polyacrylamide synthesized by electron beam irradiation	122:176	Doxycycline drug delivery using hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide synthesized by electron beam irradiation.
32205109	4	20	theme	mechanical	792:801	arg1	properties					803:812	mechanical properties	792:812	mechanical properties	792:812	The effect of the dose of electron beam irradiation and PAAm amount on the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content were studied.
32205109	1	21	theme	O-carboxymethyl	196:210	arg1	chitosan					212:219	O-carboxymethyl chitosan	196:219	O-carboxymethyl chitosan conjugated with caffeic acid	196:248	Two hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide were synthesized using electron beam irradiation.
32205109	2	22	theme	mechanical	508:517	arg1	properties					519:528	mechanical properties	508:528	mechanical properties	508:528	The synthesized hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and mechanical properties studies.
32205109	1	23	theme	electron	311:318	arg1	irradiation					325:335	electron beam irradiation	311:335	electron beam irradiation	311:335	Two hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide were synthesized using electron beam irradiation.
32205109	5	24	theme	doxycycline	860:870	arg1	hydrogels					877:885	doxycycline form hydrogels	860:885	doxycycline form hydrogels	860:885	The release of doxycycline form hydrogels in different media obeyed the mechanism of non-Fickian diffusion and best fitted to the Higuchi model and Korsmeyer-Peppas.
32205109	1	25	theme	chitosan	212:219	arg1	composite					258:266	its composite	254:266	its composite with polyacrylamide	254:286	Two hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide were synthesized using electron beam irradiation.
32205109	1	25	theme	chitosan	212:219	arg1	hydrogels					183:191	Two hydrogels	179:191	Two hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid	179:248	Two hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide were synthesized using electron beam irradiation.
32205109	1	25	theme	chitosan	212:219	arg1	chitosan					212:219	O-carboxymethyl chitosan	196:219	O-carboxymethyl chitosan conjugated with caffeic acid	196:248	Two hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide were synthesized using electron beam irradiation.
32205109	5	26	theme	form	872:875	arg1	hydrogels					877:885	doxycycline form hydrogels	860:885	doxycycline form hydrogels	860:885	The release of doxycycline form hydrogels in different media obeyed the mechanism of non-Fickian diffusion and best fitted to the Higuchi model and Korsmeyer-Peppas.
32205109	1	27	theme	beam	320:323	arg1	irradiation					325:335	electron beam irradiation	311:335	electron beam irradiation	311:335	Two hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide were synthesized using electron beam irradiation.
32205109	2	28	theme	synthesized	342:352	arg1	hydrogels					354:362	The synthesized hydrogels	338:362	The synthesized hydrogels	338:362	The synthesized hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and mechanical properties studies.
32205109	4	29	theme	PAAm	701:704	arg1	amount					706:711	PAAm amount	701:711	PAAm amount	701:711	The effect of the dose of electron beam irradiation and PAAm amount on the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content were studied.
32205109	5	30	theme	hydrogels	877:885	arg1	release					849:855	The release	845:855	The release of doxycycline form hydrogels in different media	845:904	The release of doxycycline form hydrogels in different media obeyed the mechanism of non-Fickian diffusion and best fitted to the Higuchi model and Korsmeyer-Peppas.
32205109	6	31	theme	release	1032:1038	arg1	consideration					1040:1052	In-vitro doxycycline release consideration	1011:1052	In-vitro doxycycline release consideration	1011:1052	In-vitro doxycycline release consideration indicated that the drug's release from composite hydrogel occurs with higher amounts than the other one.
32205109	2	32	dep	Fourier	386:392	arg1	transform					394:402	transform	394:402	transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and mechanical properties studies	394:536	The synthesized hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and mechanical properties studies.
32205109	2	33	theme	electron	483:490	arg1	microscopy					492:501	scanning electron microscopy	474:501	scanning electron microscopy	474:501	The synthesized hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and mechanical properties studies.
32205109	7	34	theme	hydrogels	1222:1230	arg1	dressing					1232:1239	the prepared hydrogels dressing	1209:1239	the prepared hydrogels dressing	1209:1239	The cytotoxic study confirmed the non-toxicity of the prepared hydrogels dressing.
32205109	6	35	theme	doxycycline	1020:1030	arg1	consideration					1040:1052	In-vitro doxycycline release consideration	1011:1052	In-vitro doxycycline release consideration	1011:1052	In-vitro doxycycline release consideration indicated that the drug's release from composite hydrogel occurs with higher amounts than the other one.
32205109	0	36	theme	electron	152:159	arg1	irradiation					166:176	electron beam irradiation	152:176	electron beam irradiation	152:176	Doxycycline drug delivery using hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide synthesized by electron beam irradiation.
32205109	1	37	theme	caffeic	237:243	arg1	acid					245:248	caffeic acid	237:248	caffeic acid	237:248	Two hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide were synthesized using electron beam irradiation.
32205109	5	38	theme	non-Fickian	930:940	arg1	diffusion					942:950	non-Fickian diffusion	930:950	non-Fickian diffusion	930:950	The release of doxycycline form hydrogels in different media obeyed the mechanism of non-Fickian diffusion and best fitted to the Higuchi model and Korsmeyer-Peppas.
32205109	2	39	theme	scanning	474:481	arg1	microscopy					492:501	scanning electron microscopy	474:501	scanning electron microscopy	474:501	The synthesized hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and mechanical properties studies.
32205109	7	40	theme	dressing	1232:1239	arg1	non-toxicity					1193:1204	the non-toxicity	1189:1204	the non-toxicity of the prepared hydrogels dressing	1189:1239	The cytotoxic study confirmed the non-toxicity of the prepared hydrogels dressing.
32205109	6	41	theme	In-vitro	1011:1018	arg1	consideration					1040:1052	In-vitro doxycycline release consideration	1011:1052	In-vitro doxycycline release consideration	1011:1052	In-vitro doxycycline release consideration indicated that the drug's release from composite hydrogel occurs with higher amounts than the other one.
32205109	8	42	theme	bacteria	1288:1295	arg1	inhibition					1263:1272	the growth inhibition	1252:1272	the growth inhibition of permissive bacteria against Staphylococcus aureus and Escherichia coli	1252:1346	Moreover, the growth inhibition of permissive bacteria against Staphylococcus aureus and Escherichia coli were observed for doxycycline-loaded hydrogels.
32205109	8	43	theme	permissive	1277:1286	arg1	bacteria					1288:1295	permissive bacteria	1277:1295	permissive bacteria	1277:1295	Moreover, the growth inhibition of permissive bacteria against Staphylococcus aureus and Escherichia coli were observed for doxycycline-loaded hydrogels.
32205109	4	44	theme	amount	706:711	arg1	dose					663:666	the dose	659:666	the dose of electron beam irradiation and PAAm amount	659:711	The effect of the dose of electron beam irradiation and PAAm amount on the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content were studied.
32205109	0	45	theme	chitosan	61:68	arg1	hydrogels					32:40	hydrogels	32:40	hydrogels of O-carboxymethyl chitosan	32:68	Doxycycline drug delivery using hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide synthesized by electron beam irradiation.
32205109	5	46	theme	diffusion	942:950	arg1	mechanism					917:925	the mechanism	913:925	the mechanism of non-Fickian diffusion	913:950	The release of doxycycline form hydrogels in different media obeyed the mechanism of non-Fickian diffusion and best fitted to the Higuchi model and Korsmeyer-Peppas.
32205109	9	47	theme	practical	1446:1454	arg1	application					1456:1466	practical application	1446:1466	practical application as a new antibacterial wound dressing	1446:1504	So, the synthesized hydrogels are appropriate for practical application as a new antibacterial wound dressing.
32205109	0	48	theme	O-carboxymethyl	45:59	arg1	chitosan					61:68	O-carboxymethyl chitosan	45:68	O-carboxymethyl chitosan	45:68	Doxycycline drug delivery using hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide synthesized by electron beam irradiation.
32205109	9	49	theme	antibacterial	1477:1489	arg1	dressing					1497:1504	a new antibacterial wound dressing	1471:1504	a new antibacterial wound dressing	1471:1504	So, the synthesized hydrogels are appropriate for practical application as a new antibacterial wound dressing.
32205109	0	50	theme	beam	161:164	arg1	irradiation					166:176	electron beam irradiation	152:176	electron beam irradiation	152:176	Doxycycline drug delivery using hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide synthesized by electron beam irradiation.
32205109	9	51	theme	wound	1491:1495	arg1	dressing					1497:1504	a new antibacterial wound dressing	1471:1504	a new antibacterial wound dressing	1471:1504	So, the synthesized hydrogels are appropriate for practical application as a new antibacterial wound dressing.
32205109	1	52	with	hydrogels	183:191	arg1	polyacrylamide					273:286	polyacrylamide	273:286	polyacrylamide	273:286	Two hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide were synthesized using electron beam irradiation.
32205109	7	53	theme	prepared	1213:1220	arg1	dressing					1232:1239	the prepared hydrogels dressing	1209:1239	the prepared hydrogels dressing	1209:1239	The cytotoxic study confirmed the non-toxicity of the prepared hydrogels dressing.
32205109	5	54	theme	Higuchi	975:981	arg1	model					983:987	the Higuchi model	971:987	the Higuchi model	971:987	The release of doxycycline form hydrogels in different media obeyed the mechanism of non-Fickian diffusion and best fitted to the Higuchi model and Korsmeyer-Peppas.
32205109	2	55	dep	transform	394:402	arg1	infrared					404:411	infrared	404:411	transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and mechanical properties studies	394:536	The synthesized hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and mechanical properties studies.
32205109	4	56	theme	electron	671:678	arg1	irradiation					685:695	electron beam irradiation	671:695	electron beam irradiation	671:695	The effect of the dose of electron beam irradiation and PAAm amount on the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content were studied.
32205109	4	57	theme	gel	819:821	arg1	content					823:829	gel content	819:829	gel content	819:829	The effect of the dose of electron beam irradiation and PAAm amount on the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content were studied.
32205109	1	58	with	composite	258:266	arg1	polyacrylamide					273:286	polyacrylamide	273:286	polyacrylamide	273:286	Two hydrogels of O-carboxymethyl chitosan conjugated with caffeic acid and its composite with polyacrylamide were synthesized using electron beam irradiation.
32205109	4	59	theme	drug	778:781	arg1	release					783:789	drug release	778:789	drug release	778:789	The effect of the dose of electron beam irradiation and PAAm amount on the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content were studied.
32205109	6	60	theme	composite	1093:1101	arg1	hydrogel					1103:1110	composite hydrogel	1093:1110	composite hydrogel	1093:1110	In-vitro doxycycline release consideration indicated that the drug's release from composite hydrogel occurs with higher amounts than the other one.
32205109	8	61	theme	doxycycline-loaded	1366:1383	arg1	hydrogels					1385:1393	doxycycline-loaded hydrogels	1366:1393	doxycycline-loaded hydrogels	1366:1393	Moreover, the growth inhibition of permissive bacteria against Staphylococcus aureus and Escherichia coli were observed for doxycycline-loaded hydrogels.
32205109	2	62	theme	X-ray	427:431	arg1	diffraction					433:443	X-ray diffraction	427:443	X-ray diffraction	427:443	The synthesized hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and mechanical properties studies.
32205109	6	63	theme	other	1148:1152	arg1	one					1154:1156	the other one	1144:1156	the other one	1144:1156	In-vitro doxycycline release consideration indicated that the drug's release from composite hydrogel occurs with higher amounts than the other one.
32205109	4	64	theme	irradiation	685:695	arg1	dose					663:666	the dose	659:666	the dose of electron beam irradiation and PAAm amount	659:711	The effect of the dose of electron beam irradiation and PAAm amount on the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content were studied.
32205109	4	65	theme	beam	680:683	arg1	irradiation					685:695	electron beam irradiation	671:695	electron beam irradiation	671:695	The effect of the dose of electron beam irradiation and PAAm amount on the properties of hydrogels including swelling, drug loading, drug release, mechanical properties, and gel content were studied.
34203983	0	0	theme	Fecal	71:75	arg1	Microbiota					77:86	Fecal Microbiota	71:86	Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects	71:135	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.
34203983	6	1	theme	gut	1002:1004	arg1	health					1006:1011	gut health	1002:1011	gut health in obesity	1002:1022	This study suggests that rice bran AX may beneficially impact gut health in obesity through prebiotic activities.
34203983	6	2	from	health	1006:1011	arg1	obesity					1016:1022	obesity	1016:1022	obesity	1016:1022	This study suggests that rice bran AX may beneficially impact gut health in obesity through prebiotic activities.
34203983	3	3	theme	production	473:482	arg1	patterns					484:491	human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns	393:491	human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects	393:540	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	3	4	theme	overweight/obese	516:531	arg1	subjects					533:540	normal-weight and overweight/obese subjects	498:540	subjects	533:540	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	3	5	from	subjects	533:540	arg1	patterns					484:491	human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns	393:491	human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects	393:540	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	1	6	dep	Arabinoxylan	138:149	arg1	AX					152:153	AX	152:153	AX	152:153	Arabinoxylan (AX) is a structural polysaccharide found in wheat, rice and other cereal grains.
34203983	4	7	theme	weight	690:695	arg1	classes					697:703	both weight classes	685:703	both weight classes	685:703	Results showed that rice bran arabinoxylan modified the microbiota in fecal samples from both weight classes compared to control, significantly increasing Collinsella, Blautia and Bifidobacterium, and decreasing Sutterella, Bilophila and Parabacteroides.
34203983	4	8	theme	bran	621:624	arg1	arabinoxylan					626:637	rice bran arabinoxylan	616:637	rice bran arabinoxylan	616:637	Results showed that rice bran arabinoxylan modified the microbiota in fecal samples from both weight classes compared to control, significantly increasing Collinsella, Blautia and Bifidobacterium, and decreasing Sutterella, Bilophila and Parabacteroides.
34203983	3	9	theme	normal-weight	498:510	arg1	subjects					533:540	normal-weight and overweight/obese subjects	498:540	subjects	533:540	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	3	10	theme	gut	399:401	arg1	composition					427:437	human gut microbiota phylogenetic composition	393:437	human gut microbiota phylogenetic composition	393:437	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	0	11	theme	Normal-Weight	93:105	arg1	Subjects					128:135	Normal-Weight and Overweight/Obese Subjects	93:135	Subjects	128:135	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.
34203983	2	12	theme	AX-containing	247:259	arg1	fiber					261:265	AX-containing fiber	247:265	AX-containing fiber	247:265	Diets high in AX-containing fiber may promote gut health in obesity through prebiotic function.
34203983	1	13	theme	structural	161:170	arg1	polysaccharide					172:185	a structural polysaccharide	159:185	a structural polysaccharide found in wheat, rice and other cereal grains	159:230	Arabinoxylan (AX) is a structural polysaccharide found in wheat, rice and other cereal grains.
34203983	1	13	theme	structural	161:170	arg1	Arabinoxylan					138:149	Arabinoxylan	138:149	Arabinoxylan (AX)	138:154	Arabinoxylan (AX) is a structural polysaccharide found in wheat, rice and other cereal grains.
34203983	3	14	theme	AX	357:358	arg1	impact					339:344	the impact	335:344	the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects	335:540	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	3	15	theme	rice	374:377	arg1	fiber					384:388	rice bran fiber	374:388	rice bran fiber	374:388	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	4	16	from	microbiota	652:661	arg1	classes					697:703	both weight classes	685:703	both weight classes	685:703	Results showed that rice bran arabinoxylan modified the microbiota in fecal samples from both weight classes compared to control, significantly increasing Collinsella, Blautia and Bifidobacterium, and decreasing Sutterella, Bilophila and Parabacteroides.
34203983	4	16	from	microbiota	652:661	arg1	samples					672:678	fecal samples	666:678	fecal samples from both weight classes	666:703	Results showed that rice bran arabinoxylan modified the microbiota in fecal samples from both weight classes compared to control, significantly increasing Collinsella, Blautia and Bifidobacterium, and decreasing Sutterella, Bilophila and Parabacteroides.
34203983	0	17	theme	In	0:1	arg1	Patterns					28:35	In Vitro Fecal Fermentation Patterns	0:35	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.	0:136	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.
34203983	6	18	theme	AX	975:976	arg1	bran					970:973	rice bran AX	965:976	rice bran AX	965:976	This study suggests that rice bran AX may beneficially impact gut health in obesity through prebiotic activities.
34203983	3	19	theme	in	567:568	arg1	fermentation					582:593	in vitro fecal fermentation	567:593	in vitro fecal fermentation	567:593	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	3	20	theme	human	393:397	arg1	composition					427:437	human gut microbiota phylogenetic composition	393:437	human gut microbiota phylogenetic composition	393:437	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	0	21	theme	Fermentation	15:26	arg1	Patterns					28:35	In Vitro Fecal Fermentation Patterns	0:35	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.	0:136	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.
34203983	5	22	theme	Rice	851:854	arg1	bran					856:859	Rice bran AX	851:862	Rice bran AX	851:862	Rice bran AX also significantly increased total and individual SCFA contents (p < 0.05).
34203983	0	23	theme	Fecal	9:13	arg1	Patterns					28:35	In Vitro Fecal Fermentation Patterns	0:35	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.	0:136	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.
34203983	6	24	theme	rice	965:968	arg1	bran					970:973	rice bran AX	965:976	rice bran AX	965:976	This study suggests that rice bran AX may beneficially impact gut health in obesity through prebiotic activities.
34203983	0	25	theme	Overweight/Obese	111:126	arg1	Subjects					128:135	Normal-Weight and Overweight/Obese Subjects	93:135	Subjects	128:135	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.
34203983	2	26	theme	gut	279:281	arg1	health					283:288	gut health	279:288	gut health	279:288	Diets high in AX-containing fiber may promote gut health in obesity through prebiotic function.
34203983	3	27	dep	in	567:568	arg1	vitro					570:574	vitro	570:574	vitro	570:574	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	3	28	theme	short-chain	443:453	arg1	SCFA					467:470	SCFA	467:470	SCFA	467:470	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	3	28	theme	short-chain	443:453	arg1	acid					461:464	short-chain fatty acid	443:464	short-chain fatty acid (SCFA) production	443:482	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	3	29	theme	bran	379:382	arg1	fiber					384:388	rice bran fiber	374:388	rice bran fiber	374:388	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	5	30	theme	AX	861:862	arg1	bran					856:859	Rice bran AX	851:862	Rice bran AX	851:862	Rice bran AX also significantly increased total and individual SCFA contents (p < 0.05).
34203983	2	31	from	high	239:242	arg1	fiber					261:265	AX-containing fiber	247:265	AX-containing fiber	247:265	Diets high in AX-containing fiber may promote gut health in obesity through prebiotic function.
34203983	3	32	theme	phylogenetic	414:425	arg1	composition					427:437	human gut microbiota phylogenetic composition	393:437	human gut microbiota phylogenetic composition	393:437	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	1	33	located	found	187:191	arg1	wheat					196:200	wheat	196:200	wheat	196:200	Arabinoxylan (AX) is a structural polysaccharide found in wheat, rice and other cereal grains.
34203983	1	33	located	found	187:191	arg1	rice					203:206	rice	203:206	rice	203:206	Arabinoxylan (AX) is a structural polysaccharide found in wheat, rice and other cereal grains.
34203983	1	33	located	found	187:191	arg1	grains					225:230	other cereal grains	212:230	other cereal grains	212:230	Arabinoxylan (AX) is a structural polysaccharide found in wheat, rice and other cereal grains.
34203983	1	33	located	found	187:191	arg2	Arabinoxylan					138:149	Arabinoxylan	138:149	Arabinoxylan (AX)	138:154	Arabinoxylan (AX) is a structural polysaccharide found in wheat, rice and other cereal grains.
34203983	1	33	located	found	187:191	arg2	polysaccharide					172:185	a structural polysaccharide	159:185	a structural polysaccharide found in wheat, rice and other cereal grains	159:230	Arabinoxylan (AX) is a structural polysaccharide found in wheat, rice and other cereal grains.
34203983	1	34	theme	cereal	218:223	arg1	grains					225:230	other cereal grains	212:230	other cereal grains	212:230	Arabinoxylan (AX) is a structural polysaccharide found in wheat, rice and other cereal grains.
34203983	3	35	theme	composition	427:437	arg1	patterns					484:491	human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns	393:491	human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects	393:540	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	3	36	from	impact	339:344	arg1	patterns					484:491	human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns	393:491	human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects	393:540	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	5	37	theme	p	929:929	arg1	contents					919:926	individual SCFA contents	903:926	individual SCFA contents (p < 0.05)	903:937	Rice bran AX also significantly increased total and individual SCFA contents (p < 0.05).
34203983	5	37	theme	p	929:929	arg1	<					931:931	p < 0.05	929:936	p < 0.05	929:936	Rice bran AX also significantly increased total and individual SCFA contents (p < 0.05).
34203983	0	38	theme	Arabinoxylan	40:51	arg1	Patterns					28:35	In Vitro Fecal Fermentation Patterns	0:35	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.	0:136	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.
34203983	3	39	theme	fatty	455:459	arg1	SCFA					467:470	SCFA	467:470	SCFA	467:470	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	3	39	theme	fatty	455:459	arg1	acid					461:464	short-chain fatty acid	443:464	short-chain fatty acid (SCFA) production	443:482	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	3	40	attach	isolated	360:367	arg1	fiber					384:388	rice bran fiber	374:388	rice bran fiber	374:388	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	3	40	attach	isolated	360:367	arg2	AX					357:358	AX	357:358	AX	357:358	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	3	41	theme	fecal	576:580	arg1	fermentation					582:593	in vitro fecal fermentation	567:593	in vitro fecal fermentation	567:593	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	0	42	from	Bran	63:66	arg1	Microbiota					77:86	Fecal Microbiota	71:86	Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects	71:135	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.
34203983	0	42	from	Bran	63:66	arg1	Patterns					28:35	In Vitro Fecal Fermentation Patterns	0:35	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.	0:136	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.
34203983	2	43	from	fiber	261:265	arg1	high					239:242	high	239:242	high	239:242	Diets high in AX-containing fiber may promote gut health in obesity through prebiotic function.
34203983	4	44	theme	fecal	666:670	arg1	samples					672:678	fecal samples	666:678	fecal samples from both weight classes	666:703	Results showed that rice bran arabinoxylan modified the microbiota in fecal samples from both weight classes compared to control, significantly increasing Collinsella, Blautia and Bifidobacterium, and decreasing Sutterella, Bilophila and Parabacteroides.
34203983	4	45	dep	modified	639:646	arg1	increasing					740:749	increasing	740:749	increasing Collinsella, Blautia and Bifidobacterium	740:790	Results showed that rice bran arabinoxylan modified the microbiota in fecal samples from both weight classes compared to control, significantly increasing Collinsella, Blautia and Bifidobacterium, and decreasing Sutterella, Bilophila and Parabacteroides.
34203983	4	45	dep	modified	639:646	arg1	decreasing					797:806	decreasing	797:806	decreasing Sutterella, Bilophila and Parabacteroides	797:848	Results showed that rice bran arabinoxylan modified the microbiota in fecal samples from both weight classes compared to control, significantly increasing Collinsella, Blautia and Bifidobacterium, and decreasing Sutterella, Bilophila and Parabacteroides.
34203983	2	46	theme	prebiotic	309:317	arg1	function					319:326	prebiotic function	309:326	prebiotic function	309:326	Diets high in AX-containing fiber may promote gut health in obesity through prebiotic function.
34203983	2	47	theme	high	239:242	arg1	Diets					233:237	Diets	233:237	Diets high in AX-containing fiber	233:265	Diets high in AX-containing fiber may promote gut health in obesity through prebiotic function.
34203983	3	48	theme	acid	461:464	arg1	production					473:482	short-chain fatty acid (SCFA) production	443:482	short-chain fatty acid (SCFA) production	443:482	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	1	49	theme	other	212:216	arg1	grains					225:230	other cereal grains	212:230	other cereal grains	212:230	Arabinoxylan (AX) is a structural polysaccharide found in wheat, rice and other cereal grains.
34203983	6	50	theme	prebiotic	1032:1040	arg1	activities					1042:1051	prebiotic activities	1032:1051	prebiotic activities	1032:1051	This study suggests that rice bran AX may beneficially impact gut health in obesity through prebiotic activities.
34203983	4	51	theme	rice	616:619	arg1	arabinoxylan					626:637	rice bran arabinoxylan	616:637	rice bran arabinoxylan	616:637	Results showed that rice bran arabinoxylan modified the microbiota in fecal samples from both weight classes compared to control, significantly increasing Collinsella, Blautia and Bifidobacterium, and decreasing Sutterella, Bilophila and Parabacteroides.
34203983	5	52	theme	individual	903:912	arg1	contents					919:926	individual SCFA contents	903:926	individual SCFA contents (p < 0.05)	903:937	Rice bran AX also significantly increased total and individual SCFA contents (p < 0.05).
34203983	5	52	theme	individual	903:912	arg1	<					931:931	p < 0.05	929:936	p < 0.05	929:936	Rice bran AX also significantly increased total and individual SCFA contents (p < 0.05).
34203983	3	53	theme	microbiota	403:412	arg1	composition					427:437	human gut microbiota phylogenetic composition	393:437	human gut microbiota phylogenetic composition	393:437	Thus, the impact of soluble AX isolated from rice bran fiber on human gut microbiota phylogenetic composition and short-chain fatty acid (SCFA) production patterns from normal-weight and overweight/obese subjects was investigated through in vitro fecal fermentation.
34203983	0	54	from	Subjects	128:135	arg1	Microbiota					77:86	Fecal Microbiota	71:86	Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects	71:135	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.
34203983	0	55	theme	Rice	58:61	arg1	Bran					63:66	Rice Bran	58:66	Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects	58:135	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.
34203983	0	56	dep	In	0:1	arg1	Vitro					3:7	Vitro	3:7	Vitro	3:7	In Vitro Fecal Fermentation Patterns of Arabinoxylan from Rice Bran on Fecal Microbiota from Normal-Weight and Overweight/Obese Subjects.
34203983	5	57	theme	SCFA	914:917	arg1	contents					919:926	individual SCFA contents	903:926	individual SCFA contents (p < 0.05)	903:937	Rice bran AX also significantly increased total and individual SCFA contents (p < 0.05).
34203983	5	57	theme	SCFA	914:917	arg1	<					931:931	p < 0.05	929:936	p < 0.05	929:936	Rice bran AX also significantly increased total and individual SCFA contents (p < 0.05).
34203983	4	58	from	classes	697:703	arg1	microbiota					652:661	the microbiota	648:661	the microbiota in fecal samples from both weight classes	648:703	Results showed that rice bran arabinoxylan modified the microbiota in fecal samples from both weight classes compared to control, significantly increasing Collinsella, Blautia and Bifidobacterium, and decreasing Sutterella, Bilophila and Parabacteroides.
34203983	4	58	from	classes	697:703	arg1	samples					672:678	fecal samples	666:678	fecal samples from both weight classes	666:703	Results showed that rice bran arabinoxylan modified the microbiota in fecal samples from both weight classes compared to control, significantly increasing Collinsella, Blautia and Bifidobacterium, and decreasing Sutterella, Bilophila and Parabacteroides.
31904979	4	0	theme	force	666:670	arg1	SFM					684:686	SFM	684:686	SFM	684:686	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	4	0	theme	force	666:670	arg1	microscopy					672:681	Scanning force microscopy	657:681	Scanning force microscopy (SFM)	657:687	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	2	1	theme	first	321:325	arg1	time					327:330	the first time	317:330	the first time	317:330	Quartz crystal microbalance with dissipation monitoring (QCM-D) was used to probe the bilayer formation and to show for the first time the CNC deposition onto the SLB.
31904979	5	2	theme	electrostatic	1174:1186	arg1	interactions					1188:1199	electrostatic interactions	1174:1199	electrostatic interactions	1174:1199	The results showed that the adsorption of CNCs on the supported lipid membrane depended on lipid composition, CNC concentration, and pH conditions, and that the binding process was governed by electrostatic interactions.
31904979	3	3	theme	film	476:479	arg1	thickness					481:489	the corresponding film thickness	458:489	the corresponding film thickness	458:489	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	2	4	used	used	265:268	arg2	microbalance					212:223	Quartz crystal microbalance	197:223	Quartz crystal microbalance with dissipation monitoring (QCM-D)	197:259	Quartz crystal microbalance with dissipation monitoring (QCM-D) was used to probe the bilayer formation and to show for the first time the CNC deposition onto the SLB.
31904979	6	5	theme	relevant	1336:1343	arg1	model					1348:1352	a relevant 2D model	1334:1352	a relevant 2D model of a primary plant cell wall	1334:1381	Under suitable conditions, a uniform film was formed, with thickness corresponding to a CNC monolayer, which provides the basis for a relevant 2D model of a primary plant cell wall.
31904979	6	6	theme	CNC	1290:1292	arg1	monolayer					1294:1302	a CNC monolayer	1288:1302	a CNC monolayer	1288:1302	Under suitable conditions, a uniform film was formed, with thickness corresponding to a CNC monolayer, which provides the basis for a relevant 2D model of a primary plant cell wall.
31904979	5	7	theme	lipid	1072:1076	arg1	composition					1078:1088	lipid composition	1072:1088	lipid composition	1072:1088	The results showed that the adsorption of CNCs on the supported lipid membrane depended on lipid composition, CNC concentration, and pH conditions, and that the binding process was governed by electrostatic interactions.
31904979	6	8	theme	suitable	1208:1215	arg1	conditions					1217:1226	suitable conditions	1208:1226	suitable conditions	1208:1226	Under suitable conditions, a uniform film was formed, with thickness corresponding to a CNC monolayer, which provides the basis for a relevant 2D model of a primary plant cell wall.
31904979	3	9	theme	thickness	481:489	arg1	estimation					413:422	estimation	413:422	estimation of the adsorbed hydrated mass and the corresponding film thickness	413:489	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	4	10	theme	internal	699:706	arg1	microscopy					732:741	total internal reflection fluorescence microscopy	693:741	total internal reflection fluorescence microscopy (TIRF)	693:748	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	4	10	theme	internal	699:706	arg1	TIRF					744:747	TIRF	744:747	TIRF	744:747	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	6	11	theme	plant	1367:1371	arg1	wall					1378:1381	a primary plant cell wall	1357:1381	a primary plant cell wall	1357:1381	Under suitable conditions, a uniform film was formed, with thickness corresponding to a CNC monolayer, which provides the basis for a relevant 2D model of a primary plant cell wall.
31904979	4	12	theme	total	693:697	arg1	microscopy					732:741	total internal reflection fluorescence microscopy	693:741	total internal reflection fluorescence microscopy (TIRF)	693:748	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	4	12	theme	total	693:697	arg1	TIRF					744:747	TIRF	744:747	TIRF	744:747	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	4	13	theme	fluorescence	719:730	arg1	microscopy					732:741	total internal reflection fluorescence microscopy	693:741	total internal reflection fluorescence microscopy (TIRF)	693:748	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	4	13	theme	fluorescence	719:730	arg1	TIRF					744:747	TIRF	744:747	TIRF	744:747	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	3	14	theme	corresponding	462:474	arg1	thickness					481:489	the corresponding film thickness	458:489	the corresponding film thickness	458:489	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	3	15	theme	mass	449:452	arg1	estimation					413:422	estimation	413:422	estimation of the adsorbed hydrated mass and the corresponding film thickness	413:489	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	4	16	theme	deposited	792:800	arg1	layers					802:807	the deposited layers	788:807	the deposited layers	788:807	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	3	17	theme	adsorbed	431:438	arg1	mass					449:452	the adsorbed hydrated mass	427:452	the adsorbed hydrated mass	427:452	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	5	18	theme	CNCs	1023:1026	arg1	adsorption					1009:1018	the adsorption	1005:1018	the adsorption of CNCs on the supported lipid membrane	1005:1058	The results showed that the adsorption of CNCs on the supported lipid membrane depended on lipid composition, CNC concentration, and pH conditions, and that the binding process was governed by electrostatic interactions.
31904979	4	19	theme	concentration	942:954	arg1	effect					928:933	the effect	924:933	the effect of CNC concentration on the surface coverage	924:978	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	5	20	theme	supported	1035:1043	arg1	membrane					1051:1058	the supported lipid membrane	1031:1058	the supported lipid membrane	1031:1058	The results showed that the adsorption of CNCs on the supported lipid membrane depended on lipid composition, CNC concentration, and pH conditions, and that the binding process was governed by electrostatic interactions.
31904979	4	21	theme	CNC	938:940	arg1	concentration					942:954	CNC concentration	938:954	CNC concentration	938:954	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	3	22	theme	complementary	500:512	arg1	experiments					514:524	complementary experiments	500:524	complementary experiments using D2O as the solvent	500:549	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	4	23	theme	surface	963:969	arg1	coverage					971:978	the surface coverage	959:978	the surface coverage	959:978	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	5	24	theme	lipid	1045:1049	arg1	membrane					1051:1058	the supported lipid membrane	1031:1058	the supported lipid membrane	1031:1058	The results showed that the adsorption of CNCs on the supported lipid membrane depended on lipid composition, CNC concentration, and pH conditions, and that the binding process was governed by electrostatic interactions.
31904979	1	25	theme	cellulose	87:95	arg1	nanocrystals					97:108	cellulose nanocrystals	87:108	cellulose nanocrystals (CNCs)	87:115	The deposition of cellulose nanocrystals (CNCs) on a supported lipid bilayer (SLB) was investigated at different length scales.
31904979	1	25	theme	cellulose	87:95	arg1	CNCs					111:114	CNCs	111:114	CNCs	111:114	The deposition of cellulose nanocrystals (CNCs) on a supported lipid bilayer (SLB) was investigated at different length scales.
31904979	3	26	theme	classical	379:387	arg1	measurements					395:406	classical QCM-D measurements	379:406	classical QCM-D measurements	379:406	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	4	27	theme	layers	802:807	arg1	homogeneity					773:783	the homogeneity	769:783	the homogeneity of the deposited layers	769:807	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	2	28	theme	bilayer	283:289	arg1	formation					291:299	the bilayer formation	279:299	the bilayer formation	279:299	Quartz crystal microbalance with dissipation monitoring (QCM-D) was used to probe the bilayer formation and to show for the first time the CNC deposition onto the SLB.
31904979	4	29	used	used	755:758	arg2	TIRF					744:747	TIRF	744:747	TIRF	744:747	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	4	29	used	used	755:758	arg2	microscopy					732:741	total internal reflection fluorescence microscopy	693:741	total internal reflection fluorescence microscopy (TIRF)	693:748	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	4	29	used	used	755:758	arg2	SFM					684:686	SFM	684:686	SFM	684:686	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	4	29	used	used	755:758	arg2	microscopy					672:681	Scanning force microscopy	657:681	Scanning force microscopy (SFM)	657:687	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	3	30	theme	QCM-D	389:393	arg1	measurements					395:406	classical QCM-D measurements	379:406	classical QCM-D measurements	379:406	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	0	31	theme	Nanocrystals	24:35	arg1	Deposition					0:9	Deposition	0:9	Deposition of Cellulose Nanocrystals onto Supported Lipid Membranes.	0:67	Deposition of Cellulose Nanocrystals onto Supported Lipid Membranes.
31904979	4	32	theme	length	868:873	arg1	scales					875:880	the particle and film length scales	846:880	scales	875:880	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	4	33	from	particle	850:857	arg1	details					835:841	the structural details	820:841	the structural details at the particle and film length scales	820:880	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	4	34	theme	reflection	708:717	arg1	microscopy					732:741	total internal reflection fluorescence microscopy	693:741	total internal reflection fluorescence microscopy (TIRF)	693:748	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	4	34	theme	reflection	708:717	arg1	TIRF					744:747	TIRF	744:747	TIRF	744:747	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	6	35	theme	primary	1359:1365	arg1	wall					1378:1381	a primary plant cell wall	1357:1381	a primary plant cell wall	1357:1381	Under suitable conditions, a uniform film was formed, with thickness corresponding to a CNC monolayer, which provides the basis for a relevant 2D model of a primary plant cell wall.
31904979	1	36	theme	different	172:180	arg1	scales					189:194	different length scales	172:194	different length scales	172:194	The deposition of cellulose nanocrystals (CNCs) on a supported lipid bilayer (SLB) was investigated at different length scales.
31904979	1	37	theme	nanocrystals	97:108	arg1	deposition					73:82	The deposition	69:82	The deposition of cellulose nanocrystals (CNCs) on a supported lipid bilayer (SLB)	69:150	The deposition of cellulose nanocrystals (CNCs) on a supported lipid bilayer (SLB) was investigated at different length scales.
31904979	5	38	theme	pH	1114:1115	arg1	conditions					1117:1126	pH conditions	1114:1126	pH conditions	1114:1126	The results showed that the adsorption of CNCs on the supported lipid membrane depended on lipid composition, CNC concentration, and pH conditions, and that the binding process was governed by electrostatic interactions.
31904979	4	39	theme	film	863:866	arg1	scales					875:880	the particle and film length scales	846:880	scales	875:880	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	3	40	theme	layer	618:622	arg1	hydration					597:605	the hydration	593:605	the hydration of the CNC layer	593:622	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	4	41	theme	Scanning	657:664	arg1	SFM					684:686	SFM	684:686	SFM	684:686	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	4	41	theme	Scanning	657:664	arg1	microscopy					672:681	Scanning force microscopy	657:681	Scanning force microscopy (SFM)	657:687	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	1	42	theme	length	182:187	arg1	scales					189:194	different length scales	172:194	different length scales	172:194	The deposition of cellulose nanocrystals (CNCs) on a supported lipid bilayer (SLB) was investigated at different length scales.
31904979	0	43	theme	Supported	42:50	arg1	Membranes					58:66	Supported Lipid Membranes	42:66	Supported Lipid Membranes	42:66	Deposition of Cellulose Nanocrystals onto Supported Lipid Membranes.
31904979	2	44	with	microbalance	212:223	arg1	monitoring					242:251	dissipation monitoring	230:251	dissipation monitoring (QCM-D)	230:259	Quartz crystal microbalance with dissipation monitoring (QCM-D) was used to probe the bilayer formation and to show for the first time the CNC deposition onto the SLB.
31904979	2	44	with	microbalance	212:223	arg1	QCM-D					254:258	QCM-D	254:258	QCM-D	254:258	Quartz crystal microbalance with dissipation monitoring (QCM-D) was used to probe the bilayer formation and to show for the first time the CNC deposition onto the SLB.
31904979	4	45	from	scales	875:880	arg1	details					835:841	the structural details	820:841	the structural details at the particle and film length scales	820:880	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	3	46	theme	quantitative	563:574	arg1	determination					576:588	the quantitative determination	559:588	the quantitative determination of the hydration of the CNC layer	559:622	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	2	47	theme	CNC	336:338	arg1	deposition					340:349	the CNC deposition	332:349	the CNC deposition onto the SLB	332:362	Quartz crystal microbalance with dissipation monitoring (QCM-D) was used to probe the bilayer formation and to show for the first time the CNC deposition onto the SLB.
31904979	0	48	theme	Cellulose	14:22	arg1	Nanocrystals					24:35	Cellulose Nanocrystals	14:35	Cellulose Nanocrystals	14:35	Deposition of Cellulose Nanocrystals onto Supported Lipid Membranes.
31904979	4	49	gly	homogeneity	773:783	arg1	layers					802:807	the deposited layers	788:807	the deposited layers	788:807	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	5	50	from	adsorption	1009:1018	arg1	membrane					1051:1058	the supported lipid membrane	1031:1058	the supported lipid membrane	1031:1058	The results showed that the adsorption of CNCs on the supported lipid membrane depended on lipid composition, CNC concentration, and pH conditions, and that the binding process was governed by electrostatic interactions.
31904979	3	51	theme	CNC	614:616	arg1	layer					618:622	the CNC layer	610:622	the CNC layer	610:622	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	2	52	theme	crystal	204:210	arg1	microbalance					212:223	Quartz crystal microbalance	197:223	Quartz crystal microbalance with dissipation monitoring (QCM-D)	197:259	Quartz crystal microbalance with dissipation monitoring (QCM-D) was used to probe the bilayer formation and to show for the first time the CNC deposition onto the SLB.
31904979	0	53	theme	Lipid	52:56	arg1	Membranes					58:66	Supported Lipid Membranes	42:66	Supported Lipid Membranes	42:66	Deposition of Cellulose Nanocrystals onto Supported Lipid Membranes.
31904979	5	54	theme	CNC	1091:1093	arg1	concentration					1095:1107	CNC concentration	1091:1107	CNC concentration	1091:1107	The results showed that the adsorption of CNCs on the supported lipid membrane depended on lipid composition, CNC concentration, and pH conditions, and that the binding process was governed by electrostatic interactions.
31904979	3	55	theme	high	635:638	arg1	value					650:654	a high hydration value	633:654	a high hydration value	633:654	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	2	56	theme	Quartz	197:202	arg1	microbalance					212:223	Quartz crystal microbalance	197:223	Quartz crystal microbalance with dissipation monitoring (QCM-D)	197:259	Quartz crystal microbalance with dissipation monitoring (QCM-D) was used to probe the bilayer formation and to show for the first time the CNC deposition onto the SLB.
31904979	6	57	theme	uniform	1231:1237	arg1	film					1239:1242	a uniform film	1229:1242	a uniform film	1229:1242	Under suitable conditions, a uniform film was formed, with thickness corresponding to a CNC monolayer, which provides the basis for a relevant 2D model of a primary plant cell wall.
31904979	3	58	theme	hydration	640:648	arg1	value					650:654	a high hydration value	633:654	a high hydration value	633:654	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	3	59	theme	hydration	597:605	arg1	determination					576:588	the quantitative determination	559:588	the quantitative determination of the hydration of the CNC layer	559:622	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	3	60	theme	hydrated	440:447	arg1	mass					449:452	the adsorbed hydrated mass	427:452	the adsorbed hydrated mass	427:452	Specifically, classical QCM-D measurements gave estimation of the adsorbed hydrated mass and the corresponding film thickness, whereas complementary experiments using D2O as the solvent allowed the quantitative determination of the hydration of the CNC layer, showing a high hydration value.
31904979	4	61	from	effect	928:933	arg1	coverage					971:978	the surface coverage	959:978	the surface coverage	959:978	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	1	62	theme	supported	122:130	arg1	bilayer					138:144	a supported lipid bilayer	120:144	a supported lipid bilayer (SLB)	120:150	The deposition of cellulose nanocrystals (CNCs) on a supported lipid bilayer (SLB) was investigated at different length scales.
31904979	1	62	theme	supported	122:130	arg1	SLB					147:149	SLB	147:149	SLB	147:149	The deposition of cellulose nanocrystals (CNCs) on a supported lipid bilayer (SLB) was investigated at different length scales.
31904979	4	63	theme	structural	824:833	arg1	details					835:841	the structural details	820:841	the structural details at the particle and film length scales	820:880	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
31904979	6	64	theme	2D	1345:1346	arg1	model					1348:1352	a relevant 2D model	1334:1352	a relevant 2D model of a primary plant cell wall	1334:1381	Under suitable conditions, a uniform film was formed, with thickness corresponding to a CNC monolayer, which provides the basis for a relevant 2D model of a primary plant cell wall.
31904979	6	65	theme	cell	1373:1376	arg1	wall					1378:1381	a primary plant cell wall	1357:1381	a primary plant cell wall	1357:1381	Under suitable conditions, a uniform film was formed, with thickness corresponding to a CNC monolayer, which provides the basis for a relevant 2D model of a primary plant cell wall.
31904979	1	66	theme	lipid	132:136	arg1	bilayer					138:144	a supported lipid bilayer	120:144	a supported lipid bilayer (SLB)	120:150	The deposition of cellulose nanocrystals (CNCs) on a supported lipid bilayer (SLB) was investigated at different length scales.
31904979	1	66	theme	lipid	132:136	arg1	SLB					147:149	SLB	147:149	SLB	147:149	The deposition of cellulose nanocrystals (CNCs) on a supported lipid bilayer (SLB) was investigated at different length scales.
31904979	6	67	theme	wall	1378:1381	arg1	model					1348:1352	a relevant 2D model	1334:1352	a relevant 2D model of a primary plant cell wall	1334:1381	Under suitable conditions, a uniform film was formed, with thickness corresponding to a CNC monolayer, which provides the basis for a relevant 2D model of a primary plant cell wall.
31904979	2	68	theme	dissipation	230:240	arg1	monitoring					242:251	dissipation monitoring	230:251	dissipation monitoring (QCM-D)	230:259	Quartz crystal microbalance with dissipation monitoring (QCM-D) was used to probe the bilayer formation and to show for the first time the CNC deposition onto the SLB.
31904979	2	68	theme	dissipation	230:240	arg1	QCM-D					254:258	QCM-D	254:258	QCM-D	254:258	Quartz crystal microbalance with dissipation monitoring (QCM-D) was used to probe the bilayer formation and to show for the first time the CNC deposition onto the SLB.
31904979	5	69	theme	binding	1142:1148	arg1	process					1150:1156	the binding process	1138:1156	the binding process	1138:1156	The results showed that the adsorption of CNCs on the supported lipid membrane depended on lipid composition, CNC concentration, and pH conditions, and that the binding process was governed by electrostatic interactions.
31904979	1	70	from	deposition	73:82	arg1	bilayer					138:144	a supported lipid bilayer	120:144	a supported lipid bilayer (SLB)	120:150	The deposition of cellulose nanocrystals (CNCs) on a supported lipid bilayer (SLB) was investigated at different length scales.
31904979	1	70	from	deposition	73:82	arg1	SLB					147:149	SLB	147:149	SLB	147:149	The deposition of cellulose nanocrystals (CNCs) on a supported lipid bilayer (SLB) was investigated at different length scales.
31904979	4	71	from	information	909:919	arg1	effect					928:933	the effect	924:933	the effect of CNC concentration on the surface coverage	924:978	Scanning force microscopy (SFM) and total internal reflection fluorescence microscopy (TIRF) were used to probe the homogeneity of the deposited layers, revealing the structural details at the particle and film length scales, respectively, thus giving information on the effect of CNC concentration on the surface coverage.
32761256	7	0	theme	CONCLUSION	1388:1397	arg1	sequences					1412:1420	CONCLUSION Quantitative sequences	1388:1420	CONCLUSION Quantitative sequences	1388:1420	CONCLUSION Quantitative sequences have the potential to differentiate between filler types in a noninvasive fashion.
32761256	2	1	theme	T2	532:533	arg1	times					546:550	the T2 relaxation times	528:550	the T2 relaxation times of the fillers ex vivo	528:573	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	2	theme	buttock	339:345	arg1	collagen					371:378	collagen	371:378	collagen	371:378	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	2	theme	buttock	339:345	arg1	silicone					361:368	silicone	361:368	silicone	361:368	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	2	theme	buttock	339:345	arg1	tissues					352:358	buttock soft tissues	339:358	buttock soft tissues (silicone, collagen, and different types of hyaluronic acid)	339:419	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	1	3	theme	different	254:262	arg1	types					264:268	different types	254:268	different types of fillers in soft tissues	254:295	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	3	4	theme	morphological	678:690	arg1	sequences					692:700	the standard morphological sequences	665:700	the standard morphological sequences	665:700	Three patients addressed to assess complications with buttock fillers underwent MRI with the standard morphological sequences and an additional synthetic MRI sequence; T2 mapping was not performed for the patients.
32761256	6	5	theme	silicone	1193:1200	arg1	fillers					1202:1208	known silicone fillers	1187:1208	known silicone fillers	1187:1208	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	1	6	from	tissues	289:295	arg1	types					264:268	different types	254:268	different types of fillers in soft tissues	254:295	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	6	7	theme	collagen	1329:1336	arg1	filler					1338:1343	a collagen filler	1327:1343	a collagen filler	1327:1343	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	1	8	theme	magnetic	180:187	arg1	MRI					208:210	MRI	208:210	MRI	208:210	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	1	8	theme	magnetic	180:187	arg1	imaging					199:205	synthetic magnetic resonance imaging	170:205	synthetic magnetic resonance imaging (MRI)	170:211	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	2	9	dep	ex	567:568	arg1	vivo					570:573	vivo	570:573	vivo	570:573	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	10	theme	ex	567:568	arg1	fillers					559:565	the fillers	555:565	the fillers ex vivo	555:573	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	3	11	theme	additional	709:718	arg1	sequence					734:741	an additional synthetic MRI sequence	706:741	an additional synthetic MRI sequence	706:741	Three patients addressed to assess complications with buttock fillers underwent MRI with the standard morphological sequences and an additional synthetic MRI sequence; T2 mapping was not performed for the patients.
32761256	1	12	theme	imaging	199:205	arg1	value					161:165	the value	157:165	the value of synthetic magnetic resonance imaging (MRI) and T2 mapping	157:226	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	4	13	theme	third	871:875	arg1	patient					877:883	the third patient	867:883	the third patient	867:883	Two patients had silicone fillers, whereas the exact filler composition for the third patient was unknown.
32761256	2	14	theme	T2	497:498	arg1	sequence					508:515	an optimized T2 mapping sequence	484:515	an optimized T2 mapping sequence	484:515	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	4	15	theme	filler	844:849	arg1	composition					851:861	the exact filler composition	834:861	the exact filler composition for the third patient	834:883	Two patients had silicone fillers, whereas the exact filler composition for the third patient was unknown.
32761256	4	15	theme	filler	844:849	arg1	unknown					889:895	unknown	889:895	unknown	889:895	Two patients had silicone fillers, whereas the exact filler composition for the third patient was unknown.
32761256	2	16	dep	MATERIALS	298:306	arg1	fillers					328:334	Ex vivo fillers	320:334	Ex vivo fillers	320:334	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	3	17	theme	MRI	730:732	arg1	sequence					734:741	an additional synthetic MRI sequence	706:741	an additional synthetic MRI sequence	706:741	Three patients addressed to assess complications with buttock fillers underwent MRI with the standard morphological sequences and an additional synthetic MRI sequence; T2 mapping was not performed for the patients.
32761256	4	18	contain	had	804:806	arg1	patients					795:802	Two patients	791:802	Two patients	791:802	Two patients had silicone fillers, whereas the exact filler composition for the third patient was unknown.
32761256	4	18	contain	had	804:806	arg2	fillers					817:823	silicone fillers	808:823	silicone fillers	808:823	Two patients had silicone fillers, whereas the exact filler composition for the third patient was unknown.
32761256	6	19	theme	low	1219:1221	arg1	T1					1223:1224	low T1 and T2 values	1219:1238	T1	1223:1224	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	5	20	contain	had	1059:1061	arg1	collagen					1029:1036	collagen	1029:1036	collagen	1029:1036	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	5	20	contain	had	1059:1061	arg1	acid					1054:1057	hyaluronic acid	1043:1057	hyaluronic acid	1043:1057	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	5	20	contain	had	1059:1061	arg1	silicone					1019:1026	silicone	1019:1026	silicone	1019:1026	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	5	20	contain	had	1059:1061	arg2	characteristics					1088:1102	distinct relaxation time characteristics	1063:1102	distinct relaxation time characteristics	1063:1102	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	6	21	theme	synthetic	1118:1126	arg1	MRI					1128:1130	the synthetic MRI	1114:1130	the synthetic MRI	1114:1130	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	5	22	dep	RESULTS	898:904	arg1	showed					1003:1008	showed	1003:1008	showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics	1003:1102	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	6	23	theme	filler	1286:1291	arg1	type					1293:1296	an unknown filler type	1275:1296	an unknown filler type	1275:1296	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	5	24	from	3 T	979:981	arg1	fillers					960:966	ex vivo fillers	952:966	ex vivo fillers at 1.5 and 3 T using synthetic MRI	952:1001	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	5	24	from	3 T	979:981	arg1	Measurements					906:917	Measurements	906:917	Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI	906:1001	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	5	25	theme	T1	922:923	arg1	Measurements					906:917	Measurements	906:917	Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI	906:1001	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	5	26	theme	T2	929:930	arg1	Measurements					906:917	Measurements	906:917	Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI	906:1001	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	0	27	theme	Quantitative	0:11	arg1	resonance					22:30	Quantitative magnetic resonance	0:30	Quantitative magnetic resonance imaging: differentiating soft tissue implants and fillers used in cosmetic and reconstructive surgery.	0:133	Quantitative magnetic resonance imaging: differentiating soft tissue implants and fillers used in cosmetic and reconstructive surgery.
32761256	1	28	theme	fillers	273:279	arg1	types					264:268	different types	254:268	different types of fillers in soft tissues	254:295	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	2	29	theme	acid	415:418	arg1	collagen					371:378	collagen	371:378	collagen	371:378	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	29	theme	acid	415:418	arg1	tissues					352:358	buttock soft tissues	339:358	buttock soft tissues (silicone, collagen, and different types of hyaluronic acid)	339:419	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	29	theme	acid	415:418	arg1	silicone					361:368	silicone	361:368	silicone	361:368	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	29	theme	acid	415:418	arg1	types					395:399	different types	385:399	different types of hyaluronic acid	385:418	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	1	30	theme	soft	284:287	arg1	tissues					289:295	soft tissues	284:295	soft tissues	284:295	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	2	31	theme	synthetic	442:450	arg1	sequence					456:463	a synthetic MRI sequence	440:463	a synthetic MRI sequence at 1.5 and 3 T	440:478	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	32	theme	different	385:393	arg1	types					395:399	different types	385:399	different types of hyaluronic acid	385:418	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	6	33	theme	synthetic	1303:1311	arg1	MRI					1313:1315	the synthetic MRI	1299:1315	the synthetic MRI	1299:1315	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	5	34	theme	distinct	1063:1070	arg1	characteristics					1088:1102	distinct relaxation time characteristics	1063:1102	distinct relaxation time characteristics	1063:1102	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	5	35	theme	fillers	960:966	arg1	Measurements					906:917	Measurements	906:917	Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI	906:1001	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	0	36	theme	soft	57:60	arg1	implants					69:76	differentiating soft tissue implants	41:76	differentiating soft tissue implants	41:76	Quantitative magnetic resonance imaging: differentiating soft tissue implants and fillers used in cosmetic and reconstructive surgery.
32761256	5	37	theme	time	1083:1086	arg1	characteristics					1088:1102	distinct relaxation time characteristics	1063:1102	distinct relaxation time characteristics	1063:1102	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	3	38	theme	buttock	630:636	arg1	fillers					638:644	buttock fillers	630:644	buttock fillers	630:644	Three patients addressed to assess complications with buttock fillers underwent MRI with the standard morphological sequences and an additional synthetic MRI sequence; T2 mapping was not performed for the patients.
32761256	5	39	from	Measurements	906:917	arg1	3 T					979:981	3 T	979:981	3 T	979:981	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	5	39	from	Measurements	906:917	arg1	1.5					971:973	1.5	971:973	1.5	971:973	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	1	40	theme	T2	217:218	arg1	mapping					220:226	T2 mapping	217:226	T2 mapping	217:226	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	7	41	theme	Quantitative	1399:1410	arg1	sequences					1412:1420	CONCLUSION Quantitative sequences	1388:1420	CONCLUSION Quantitative sequences	1388:1420	CONCLUSION Quantitative sequences have the potential to differentiate between filler types in a noninvasive fashion.
32761256	0	42	dep	resonance	22:30	arg1	fillers					82:88	fillers	82:88	fillers	82:88	Quantitative magnetic resonance imaging: differentiating soft tissue implants and fillers used in cosmetic and reconstructive surgery.
32761256	0	42	dep	resonance	22:30	arg1	implants					69:76	differentiating soft tissue implants	41:76	differentiating soft tissue implants	41:76	Quantitative magnetic resonance imaging: differentiating soft tissue implants and fillers used in cosmetic and reconstructive surgery.
32761256	6	43	theme	time	1375:1378	arg1	values					1380:1385	intermediate relaxation time values	1351:1385	intermediate relaxation time values	1351:1385	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	5	44	theme	ex	952:953	arg1	fillers					960:966	ex vivo fillers	952:966	ex vivo fillers at 1.5 and 3 T using synthetic MRI	952:1001	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	2	45	theme	soft	347:350	arg1	collagen					371:378	collagen	371:378	collagen	371:378	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	45	theme	soft	347:350	arg1	silicone					361:368	silicone	361:368	silicone	361:368	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	45	theme	soft	347:350	arg1	tissues					352:358	buttock soft tissues	339:358	buttock soft tissues (silicone, collagen, and different types of hyaluronic acid)	339:419	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	6	46	theme	intermediate	1351:1362	arg1	values					1380:1385	intermediate relaxation time values	1351:1385	intermediate relaxation time values	1351:1385	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	4	47	theme	silicone	808:815	arg1	fillers					817:823	silicone fillers	808:823	silicone fillers	808:823	Two patients had silicone fillers, whereas the exact filler composition for the third patient was unknown.
32761256	2	48	theme	relaxation	535:544	arg1	times					546:550	the T2 relaxation times	528:550	the T2 relaxation times of the fillers ex vivo	528:573	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	6	49	theme	known	1187:1191	arg1	fillers					1202:1208	known silicone fillers	1187:1208	known silicone fillers	1187:1208	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	3	50	with	complications	611:623	arg1	fillers					638:644	buttock fillers	630:644	buttock fillers	630:644	Three patients addressed to assess complications with buttock fillers underwent MRI with the standard morphological sequences and an additional synthetic MRI sequence; T2 mapping was not performed for the patients.
32761256	1	51	theme	synthetic	170:178	arg1	MRI					208:210	MRI	208:210	MRI	208:210	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	1	51	theme	synthetic	170:178	arg1	imaging					199:205	synthetic magnetic resonance imaging	170:205	synthetic magnetic resonance imaging (MRI)	170:211	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	3	52	theme	standard	669:676	arg1	sequences					692:700	the standard morphological sequences	665:700	the standard morphological sequences	665:700	Three patients addressed to assess complications with buttock fillers underwent MRI with the standard morphological sequences and an additional synthetic MRI sequence; T2 mapping was not performed for the patients.
32761256	1	53	from	fillers	273:279	arg1	tissues					289:295	soft tissues	284:295	soft tissues	284:295	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	1	54	theme	resonance	189:197	arg1	MRI					208:210	MRI	208:210	MRI	208:210	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	1	54	theme	resonance	189:197	arg1	imaging					199:205	synthetic magnetic resonance imaging	170:205	synthetic magnetic resonance imaging (MRI)	170:211	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	2	55	theme	fillers	559:565	arg1	times					546:550	the T2 relaxation times	528:550	the T2 relaxation times of the fillers ex vivo	528:573	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	3	56	theme	synthetic	720:728	arg1	sequence					734:741	an additional synthetic MRI sequence	706:741	an additional synthetic MRI sequence	706:741	Three patients addressed to assess complications with buttock fillers underwent MRI with the standard morphological sequences and an additional synthetic MRI sequence; T2 mapping was not performed for the patients.
32761256	1	57	from	types	264:268	arg1	tissues					289:295	soft tissues	284:295	soft tissues	284:295	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	5	58	from	1.5	971:973	arg1	fillers					960:966	ex vivo fillers	952:966	ex vivo fillers at 1.5 and 3 T using synthetic MRI	952:1001	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	5	58	from	1.5	971:973	arg1	Measurements					906:917	Measurements	906:917	Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI	906:1001	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	2	59	theme	mapping	500:506	arg1	sequence					508:515	an optimized T2 mapping sequence	484:515	an optimized T2 mapping sequence	484:515	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	5	60	dep	ex	952:953	arg1	vivo					955:958	vivo	955:958	vivo	955:958	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	7	61	contain	have	1422:1425	arg1	sequences					1412:1420	CONCLUSION Quantitative sequences	1388:1420	CONCLUSION Quantitative sequences	1388:1420	CONCLUSION Quantitative sequences have the potential to differentiate between filler types in a noninvasive fashion.
32761256	7	61	contain	have	1422:1425	arg2	potential					1431:1439	the potential to differentiate between filler types in a noninvasive fashion	1427:1502	the potential to differentiate between filler types in a noninvasive fashion	1427:1502	CONCLUSION Quantitative sequences have the potential to differentiate between filler types in a noninvasive fashion.
32761256	2	62	theme	optimized	487:495	arg1	sequence					508:515	an optimized T2 mapping sequence	484:515	an optimized T2 mapping sequence	484:515	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	63	from	1.5	468:470	arg1	sequence					508:515	an optimized T2 mapping sequence	484:515	an optimized T2 mapping sequence	484:515	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	63	from	1.5	468:470	arg1	sequence					456:463	a synthetic MRI sequence	440:463	a synthetic MRI sequence at 1.5 and 3 T	440:478	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	3	64	theme	T2	744:745	arg1	mapping					747:753	T2 mapping	744:753	T2 mapping	744:753	Three patients addressed to assess complications with buttock fillers underwent MRI with the standard morphological sequences and an additional synthetic MRI sequence; T2 mapping was not performed for the patients.
32761256	6	65	theme	T2	1230:1231	arg1	values					1233:1238	low T1 and T2 values	1219:1238	values	1233:1238	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	4	66	theme	exact	838:842	arg1	composition					851:861	the exact filler composition	834:861	the exact filler composition for the third patient	834:883	Two patients had silicone fillers, whereas the exact filler composition for the third patient was unknown.
32761256	4	66	theme	exact	838:842	arg1	unknown					889:895	unknown	889:895	unknown	889:895	Two patients had silicone fillers, whereas the exact filler composition for the third patient was unknown.
32761256	2	67	from	3 T	476:478	arg1	sequence					508:515	an optimized T2 mapping sequence	484:515	an optimized T2 mapping sequence	484:515	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	67	from	3 T	476:478	arg1	sequence					456:463	a synthetic MRI sequence	440:463	a synthetic MRI sequence at 1.5 and 3 T	440:478	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	5	68	dep	T1	922:923	arg1	times					943:947	relaxation times	932:947	relaxation times	932:947	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	5	69	theme	synthetic	989:997	arg1	MRI					999:1001	synthetic MRI	989:1001	synthetic MRI	989:1001	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	7	70	theme	noninvasive	1484:1494	arg1	fashion					1496:1502	a noninvasive fashion	1482:1502	a noninvasive fashion	1482:1502	CONCLUSION Quantitative sequences have the potential to differentiate between filler types in a noninvasive fashion.
32761256	6	71	dep	identified	1142:1151	arg1	whereas					1241:1247	whereas	1241:1247	whereas	1241:1247	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	6	72	theme	unknown	1278:1284	arg1	type					1293:1296	an unknown filler type	1275:1296	an unknown filler type	1275:1296	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	5	73	theme	hyaluronic	1043:1052	arg1	acid					1054:1057	hyaluronic acid	1043:1057	hyaluronic acid	1043:1057	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	6	74	with	patient	1262:1268	arg1	type					1293:1296	an unknown filler type	1275:1296	an unknown filler type	1275:1296	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	2	75	theme	MRI	452:454	arg1	sequence					456:463	a synthetic MRI sequence	440:463	a synthetic MRI sequence at 1.5 and 3 T	440:478	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	7	76	theme	filler	1466:1471	arg1	types					1473:1477	filler types	1466:1477	filler types	1466:1477	CONCLUSION Quantitative sequences have the potential to differentiate between filler types in a noninvasive fashion.
32761256	6	77	theme	third	1256:1260	arg1	patient					1262:1268	the third patient	1252:1268	the third patient with an unknown filler type	1252:1296	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	2	78	dep	tissues	352:358	arg1	collagen					371:378	collagen	371:378	collagen	371:378	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	78	dep	tissues	352:358	arg1	tissues					352:358	buttock soft tissues	339:358	buttock soft tissues (silicone, collagen, and different types of hyaluronic acid)	339:419	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	78	dep	tissues	352:358	arg1	silicone					361:368	silicone	361:368	silicone	361:368	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	78	dep	tissues	352:358	arg1	types					395:399	different types	385:399	different types of hyaluronic acid	385:418	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	0	79	theme	reconstructive	111:124	arg1	surgery					126:132	reconstructive surgery	111:132	reconstructive surgery	111:132	Quantitative magnetic resonance imaging: differentiating soft tissue implants and fillers used in cosmetic and reconstructive surgery.
32761256	0	80	theme	magnetic	13:20	arg1	resonance					22:30	Quantitative magnetic resonance	0:30	Quantitative magnetic resonance imaging: differentiating soft tissue implants and fillers used in cosmetic and reconstructive surgery.	0:133	Quantitative magnetic resonance imaging: differentiating soft tissue implants and fillers used in cosmetic and reconstructive surgery.
32761256	2	81	dep	Ex	320:321	arg1	vivo					323:326	vivo	323:326	vivo	323:326	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	82	theme	hyaluronic	404:413	arg1	acid					415:418	hyaluronic acid	404:418	hyaluronic acid	404:418	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	0	83	theme	differentiating	41:55	arg1	implants					69:76	differentiating soft tissue implants	41:76	differentiating soft tissue implants	41:76	Quantitative magnetic resonance imaging: differentiating soft tissue implants and fillers used in cosmetic and reconstructive surgery.
32761256	0	84	theme	tissue	62:67	arg1	implants					69:76	differentiating soft tissue implants	41:76	differentiating soft tissue implants	41:76	Quantitative magnetic resonance imaging: differentiating soft tissue implants and fillers used in cosmetic and reconstructive surgery.
32761256	5	85	theme	relaxation	1072:1081	arg1	characteristics					1088:1102	distinct relaxation time characteristics	1063:1102	distinct relaxation time characteristics	1063:1102	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	5	86	theme	relaxation	932:941	arg1	times					943:947	relaxation times	932:947	relaxation times	932:947	RESULTS Measurements of T1 and T2 relaxation times of ex vivo fillers at 1.5 and 3 T using synthetic MRI showed that the silicone, collagen, and hyaluronic acid had distinct relaxation time characteristics.
32761256	2	87	theme	Ex	320:321	arg1	fillers					328:334	Ex vivo fillers	320:334	Ex vivo fillers	320:334	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	1	88	theme	mapping	220:226	arg1	value					161:165	the value	157:165	the value of synthetic magnetic resonance imaging (MRI) and T2 mapping	157:226	OBJECTIVE To evaluate the value of synthetic magnetic resonance imaging (MRI) and T2 mapping in distinguishing between different types of fillers in soft tissues.
32761256	6	89	theme	relaxation	1364:1373	arg1	values					1380:1385	intermediate relaxation time values	1351:1385	intermediate relaxation time values	1351:1385	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32761256	2	90	theme	tissues	352:358	arg1	MATERIALS					298:306	MATERIALS	298:306	MATERIALS	298:306	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	2	90	theme	tissues	352:358	arg1	METHODS					312:318	METHODS	312:318	METHODS	312:318	MATERIALS AND METHODS Ex vivo fillers of buttock soft tissues (silicone, collagen, and different types of hyaluronic acid) were scanned using a synthetic MRI sequence at 1.5 and 3 T and an optimized T2 mapping sequence to measure the T2 relaxation times of the fillers ex vivo.
32761256	6	91	with	patients	1173:1180	arg1	fillers					1202:1208	known silicone fillers	1187:1208	known silicone fillers	1187:1208	In vivo, the synthetic MRI correctly identified silicone in the two patients with known silicone fillers, showing low T1 and T2 values, whereas in the third patient with an unknown filler type, the synthetic MRI suggested a collagen filler, with intermediate relaxation time values.
32599236	2	0	theme	fixed	541:545	arg1	systems					551:557	batch and continuous fixed bed systems	520:557	batch and continuous fixed bed systems	520:557	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	8	1	theme	Thomas	1604:1609	arg1	models					1594:1599	models	1594:1599	models of Thomas, Yoon-Nelson, and Modified Dose Response	1594:1650	The continuous adsorption was investigated by Thomas, Adam-Bohart, Yoon-Nelson, Wolborska, and Modified Dose Response kinetic models and the results showed that the adsorbents showed more consistency with models of Thomas, Yoon-Nelson, and Modified Dose Response.
32599236	2	2	theme	different	399:407	arg1	compositions					409:420	different compositions	399:420	different compositions	399:420	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	6	3	theme	kinetic	1072:1078	arg1	models					1080:1085	pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models	993:1085	pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models	993:1085	The batch adsorption was investigated using pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models and the results showed that all four adsorbents are consistent with all models but the pseudo-first-order model showed more consistency.
32599236	0	4	theme	aqueous	79:85	arg1	solution					87:94	aqueous solution	79:94	aqueous solution	79:94	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.
32599236	6	5	theme	batch	953:957	arg1	adsorption					959:968	The batch adsorption	949:968	The batch adsorption	949:968	The batch adsorption was investigated using pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models and the results showed that all four adsorbents are consistent with all models but the pseudo-first-order model showed more consistency.
32599236	6	6	with	consistent	1139:1148	arg1	models					1159:1164	all models	1155:1164	all models	1155:1164	The batch adsorption was investigated using pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models and the results showed that all four adsorbents are consistent with all models but the pseudo-first-order model showed more consistency.
32599236	6	7	theme	Elovich	1064:1070	arg1	models					1080:1085	pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models	993:1085	pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models	993:1085	The batch adsorption was investigated using pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models and the results showed that all four adsorbents are consistent with all models but the pseudo-first-order model showed more consistency.
32599236	0	8	theme	batch	99:103	arg1	systems					130:136	batch and continuous fixed bed systems	99:136	batch and continuous fixed bed systems	99:136	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.
32599236	2	9	theme	cellulose-based	310:324	arg1	beads					388:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads	296:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions	296:420	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	2	10	theme	carboxymethyl	296:308	arg1	beads					388:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads	296:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions	296:420	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	6	11	theme	pseudo-first-order	1174:1191	arg1	model					1193:1197	the pseudo-first-order model	1170:1197	the pseudo-first-order model	1170:1197	The batch adsorption was investigated using pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models and the results showed that all four adsorbents are consistent with all models but the pseudo-first-order model showed more consistency.
32599236	0	12	theme	continuous	109:118	arg1	systems					130:136	batch and continuous fixed bed systems	99:136	batch and continuous fixed bed systems	99:136	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.
32599236	2	13	from	solution	508:515	arg1	removal					487:493	methylene blue removal	472:493	methylene blue removal from aqueous solution in batch and continuous fixed bed systems	472:557	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	5	14	theme	batch	803:807	arg1	capacities					820:829	The equilibrium batch adsorption capacities	787:829	The equilibrium batch adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents	787:891	The equilibrium batch adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 12.01, 13.06, 11.53, and 10.49 mg/g, respectively.
32599236	5	14	theme	batch	803:807	arg1	12.01					898:902	12.01	898:902	12.01	898:902	The equilibrium batch adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 12.01, 13.06, 11.53, and 10.49 mg/g, respectively.
32599236	2	15	theme	aqueous	500:506	arg1	solution					508:515	aqueous solution	500:515	aqueous solution	500:515	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	4	16	theme	concentration	693:705	arg1	effect					674:679	The effect	670:679	The effect of time and concentration on adsorption processes, regeneration, and reuse investigations	670:769	The effect of time and concentration on adsorption processes, regeneration, and reuse investigations were performed.
32599236	0	17	theme	hollow	6:11	arg1	beads					13:17	Novel hollow beads	0:17	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.	0:137	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.
32599236	2	18	theme	continuous	530:539	arg1	systems					551:557	batch and continuous fixed bed systems	520:557	batch and continuous fixed bed systems	520:557	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	8	19	dep	Adam-Bohart	1443:1453	arg1	models					1515:1520	kinetic models	1507:1520	kinetic models	1507:1520	The continuous adsorption was investigated by Thomas, Adam-Bohart, Yoon-Nelson, Wolborska, and Modified Dose Response kinetic models and the results showed that the adsorbents showed more consistency with models of Thomas, Yoon-Nelson, and Modified Dose Response.
32599236	0	20	theme	Novel	0:4	arg1	beads					13:17	Novel hollow beads	0:17	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.	0:137	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.
32599236	6	21	theme	diffusion	1049:1057	arg1	models					1080:1085	pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models	993:1085	pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models	993:1085	The batch adsorption was investigated using pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models and the results showed that all four adsorbents are consistent with all models but the pseudo-first-order model showed more consistency.
32599236	2	22	theme	framework	353:361	arg1	beads					388:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads	296:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions	296:420	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	1	23	theme	metal-organic	186:198	arg1	frameworks					200:209	metal-organic frameworks	186:209	metal-organic frameworks that are topologically isomorphic with zeolites	186:257	Zeolitic imidazolate frameworks are a class of metal-organic frameworks that are topologically isomorphic with zeolites.
32599236	5	24	theme	CMC/ZSM-5/ZIF-8	866:880	arg1	adsorbents					882:891	CMC/ZSM-5/ZIF-8 adsorbents	866:891	CMC/ZSM-5/ZIF-8 adsorbents	866:891	The equilibrium batch adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 12.01, 13.06, 11.53, and 10.49 mg/g, respectively.
32599236	6	25	theme	intra-particle	1034:1047	arg1	diffusion					1049:1057	intra-particle diffusion	1034:1057	intra-particle diffusion	1034:1057	The batch adsorption was investigated using pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models and the results showed that all four adsorbents are consistent with all models but the pseudo-first-order model showed more consistency.
32599236	0	26	theme	bed	126:128	arg1	systems					130:136	batch and continuous fixed bed systems	99:136	batch and continuous fixed bed systems	99:136	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.
32599236	2	27	theme	imidazolate	341:351	arg1	beads					388:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads	296:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions	296:420	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	1	28	theme	frameworks	200:209	arg1	frameworks					160:169	Zeolitic imidazolate frameworks	139:169	Zeolitic imidazolate frameworks	139:169	Zeolitic imidazolate frameworks are a class of metal-organic frameworks that are topologically isomorphic with zeolites.
32599236	1	28	theme	frameworks	200:209	arg1	class					177:181	a class	175:181	a class of metal-organic frameworks that are topologically isomorphic with zeolites	175:257	Zeolitic imidazolate frameworks are a class of metal-organic frameworks that are topologically isomorphic with zeolites.
32599236	2	29	theme	blue	482:485	arg1	removal					487:493	methylene blue removal	472:493	methylene blue removal from aqueous solution in batch and continuous fixed bed systems	472:557	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	8	30	theme	Modified	1629:1636	arg1	Response					1643:1650	Modified Dose Response	1629:1650	Modified Dose Response	1629:1650	The continuous adsorption was investigated by Thomas, Adam-Bohart, Yoon-Nelson, Wolborska, and Modified Dose Response kinetic models and the results showed that the adsorbents showed more consistency with models of Thomas, Yoon-Nelson, and Modified Dose Response.
32599236	0	31	theme	fixed	120:124	arg1	systems					130:136	batch and continuous fixed bed systems	99:136	batch and continuous fixed bed systems	99:136	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.
32599236	0	32	from	solution	87:94	arg1	removal					66:72	dye removal	62:72	dye removal from aqueous solution in batch and continuous fixed bed systems	62:136	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.
32599236	2	33	theme	ZSM-5/zeolitic	326:339	arg1	beads					388:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads	296:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions	296:420	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	7	34	theme	equilibrium	1228:1238	arg1	10.56					1340:1344	10.56	1340:1344	10.56	1340:1344	The equilibrium continuous adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 10.56, 11.87, 9.29, and 8.15 mg/g, respectively.
32599236	7	34	theme	equilibrium	1228:1238	arg1	capacities					1262:1271	The equilibrium continuous adsorption capacities	1224:1271	The equilibrium continuous adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents	1224:1333	The equilibrium continuous adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 10.56, 11.87, 9.29, and 8.15 mg/g, respectively.
32599236	8	35	theme	kinetic	1507:1513	arg1	models					1515:1520	kinetic models	1507:1520	kinetic models	1507:1520	The continuous adsorption was investigated by Thomas, Adam-Bohart, Yoon-Nelson, Wolborska, and Modified Dose Response kinetic models and the results showed that the adsorbents showed more consistency with models of Thomas, Yoon-Nelson, and Modified Dose Response.
32599236	0	36	theme	cellulose/ZSM-5/ZIF-8	36:56	arg1	beads					13:17	Novel hollow beads	0:17	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.	0:137	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.
32599236	4	37	theme	reuse	750:754	arg1	investigations					756:769	reuse investigations	750:769	reuse investigations	750:769	The effect of time and concentration on adsorption processes, regeneration, and reuse investigations were performed.
32599236	6	38	theme	pseudo-second-order	1013:1031	arg1	models					1080:1085	pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models	993:1085	pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models	993:1085	The batch adsorption was investigated using pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models and the results showed that all four adsorbents are consistent with all models but the pseudo-first-order model showed more consistency.
32599236	4	39	theme	adsorption	710:719	arg1	processes					721:729	adsorption processes	710:729	adsorption processes	710:729	The effect of time and concentration on adsorption processes, regeneration, and reuse investigations were performed.
32599236	0	40	theme	carboxymethyl	22:34	arg1	cellulose/ZSM-5/ZIF-8					36:56	carboxymethyl cellulose/ZSM-5/ZIF-8	22:56	carboxymethyl cellulose/ZSM-5/ZIF-8	22:56	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.
32599236	8	41	theme	Response	1643:1650	arg1	models					1594:1599	models	1594:1599	models of Thomas, Yoon-Nelson, and Modified Dose Response	1594:1650	The continuous adsorption was investigated by Thomas, Adam-Bohart, Yoon-Nelson, Wolborska, and Modified Dose Response kinetic models and the results showed that the adsorbents showed more consistency with models of Thomas, Yoon-Nelson, and Modified Dose Response.
32599236	2	42	theme	batch	520:524	arg1	systems					551:557	batch and continuous fixed bed systems	520:557	batch and continuous fixed bed systems	520:557	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	2	43	with	beads	388:392	arg1	compositions					409:420	different compositions	399:420	different compositions	399:420	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	7	44	theme	continuous	1240:1249	arg1	10.56					1340:1344	10.56	1340:1344	10.56	1340:1344	The equilibrium continuous adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 10.56, 11.87, 9.29, and 8.15 mg/g, respectively.
32599236	7	44	theme	continuous	1240:1249	arg1	capacities					1262:1271	The equilibrium continuous adsorption capacities	1224:1271	The equilibrium continuous adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents	1224:1333	The equilibrium continuous adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 10.56, 11.87, 9.29, and 8.15 mg/g, respectively.
32599236	4	45	theme	time	684:687	arg1	effect					674:679	The effect	670:679	The effect of time and concentration on adsorption processes, regeneration, and reuse investigations	670:769	The effect of time and concentration on adsorption processes, regeneration, and reuse investigations were performed.
32599236	0	46	theme	dye	62:64	arg1	removal					66:72	dye removal	62:72	dye removal from aqueous solution in batch and continuous fixed bed systems	62:136	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.
32599236	6	47	theme	pseudo-first-order	993:1010	arg1	models					1080:1085	pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models	993:1085	pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models	993:1085	The batch adsorption was investigated using pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models and the results showed that all four adsorbents are consistent with all models but the pseudo-first-order model showed more consistency.
32599236	0	48	from	removal	66:72	arg1	systems					130:136	batch and continuous fixed bed systems	99:136	batch and continuous fixed bed systems	99:136	Novel hollow beads of carboxymethyl cellulose/ZSM-5/ZIF-8 for dye removal from aqueous solution in batch and continuous fixed bed systems.
32599236	9	49	theme	generation	1666:1675	arg1	process					1677:1683	the generation process	1662:1683	the generation process	1662:1683	Besides, the generation process was successfully assessed in five steps.
32599236	2	50	theme	beads	388:392	arg1	adsorbent					458:466	adsorbent	458:466	adsorbent	458:466	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	2	50	theme	beads	388:392	arg1	bionanocomposites					275:291	bionanocomposites	275:291	bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions	275:420	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	2	50	theme	beads	388:392	arg1	beads					388:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads	296:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions	296:420	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	8	51	theme	more	1572:1575	arg1	consistency					1577:1587	more consistency	1572:1587	more consistency	1572:1587	The continuous adsorption was investigated by Thomas, Adam-Bohart, Yoon-Nelson, Wolborska, and Modified Dose Response kinetic models and the results showed that the adsorbents showed more consistency with models of Thomas, Yoon-Nelson, and Modified Dose Response.
32599236	8	52	theme	continuous	1393:1402	arg1	adsorption					1404:1413	The continuous adsorption	1389:1413	The continuous adsorption	1389:1413	The continuous adsorption was investigated by Thomas, Adam-Bohart, Yoon-Nelson, Wolborska, and Modified Dose Response kinetic models and the results showed that the adsorbents showed more consistency with models of Thomas, Yoon-Nelson, and Modified Dose Response.
32599236	3	53	dep	FESEM	560:564	arg1	measurements					586:597	measurements	586:597	measurements	586:597	FESEM, FTIR, XRD, and BET measurements have been employed for characterizing the synthetic bionanocomposites.
32599236	2	54	theme	hollow	381:386	arg1	beads					388:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads	296:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions	296:420	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	8	55	theme	Dose	1493:1496	arg1	Response					1498:1505	Modified Dose Response	1484:1505	Modified Dose Response	1484:1505	The continuous adsorption was investigated by Thomas, Adam-Bohart, Yoon-Nelson, Wolborska, and Modified Dose Response kinetic models and the results showed that the adsorbents showed more consistency with models of Thomas, Yoon-Nelson, and Modified Dose Response.
32599236	5	56	theme	equilibrium	791:801	arg1	capacities					820:829	The equilibrium batch adsorption capacities	787:829	The equilibrium batch adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents	787:891	The equilibrium batch adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 12.01, 13.06, 11.53, and 10.49 mg/g, respectively.
32599236	5	56	theme	equilibrium	791:801	arg1	12.01					898:902	12.01	898:902	12.01	898:902	The equilibrium batch adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 12.01, 13.06, 11.53, and 10.49 mg/g, respectively.
32599236	4	57	from	effect	674:679	arg1	investigations					756:769	reuse investigations	750:769	reuse investigations	750:769	The effect of time and concentration on adsorption processes, regeneration, and reuse investigations were performed.
32599236	4	57	from	effect	674:679	arg1	regeneration					732:743	regeneration	732:743	regeneration	732:743	The effect of time and concentration on adsorption processes, regeneration, and reuse investigations were performed.
32599236	4	57	from	effect	674:679	arg1	processes					721:729	adsorption processes	710:729	adsorption processes	710:729	The effect of time and concentration on adsorption processes, regeneration, and reuse investigations were performed.
32599236	8	58	theme	Modified	1484:1491	arg1	Response					1498:1505	Modified Dose Response	1484:1505	Modified Dose Response	1484:1505	The continuous adsorption was investigated by Thomas, Adam-Bohart, Yoon-Nelson, Wolborska, and Modified Dose Response kinetic models and the results showed that the adsorbents showed more consistency with models of Thomas, Yoon-Nelson, and Modified Dose Response.
32599236	2	59	theme	CMC/ZSM-5/ZIF-8	364:378	arg1	beads					388:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads	296:392	carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions	296:420	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	6	60	theme	more	1206:1209	arg1	consistency					1211:1221	more consistency	1206:1221	more consistency	1206:1221	The batch adsorption was investigated using pseudo-first-order, pseudo-second-order, intra-particle diffusion, and Elovich kinetic models and the results showed that all four adsorbents are consistent with all models but the pseudo-first-order model showed more consistency.
32599236	5	61	theme	adsorption	809:818	arg1	capacities					820:829	The equilibrium batch adsorption capacities	787:829	The equilibrium batch adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents	787:891	The equilibrium batch adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 12.01, 13.06, 11.53, and 10.49 mg/g, respectively.
32599236	5	61	theme	adsorption	809:818	arg1	12.01					898:902	12.01	898:902	12.01	898:902	The equilibrium batch adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 12.01, 13.06, 11.53, and 10.49 mg/g, respectively.
32599236	3	62	theme	synthetic	641:649	arg1	bionanocomposites					651:667	the synthetic bionanocomposites	637:667	the synthetic bionanocomposites	637:667	FESEM, FTIR, XRD, and BET measurements have been employed for characterizing the synthetic bionanocomposites.
32599236	8	63	theme	Yoon-Nelson	1612:1622	arg1	models					1594:1599	models	1594:1599	models of Thomas, Yoon-Nelson, and Modified Dose Response	1594:1650	The continuous adsorption was investigated by Thomas, Adam-Bohart, Yoon-Nelson, Wolborska, and Modified Dose Response kinetic models and the results showed that the adsorbents showed more consistency with models of Thomas, Yoon-Nelson, and Modified Dose Response.
32599236	1	64	theme	Zeolitic	139:146	arg1	frameworks					160:169	Zeolitic imidazolate frameworks	139:169	Zeolitic imidazolate frameworks	139:169	Zeolitic imidazolate frameworks are a class of metal-organic frameworks that are topologically isomorphic with zeolites.
32599236	1	64	theme	Zeolitic	139:146	arg1	class					177:181	a class	175:181	a class of metal-organic frameworks that are topologically isomorphic with zeolites	175:257	Zeolitic imidazolate frameworks are a class of metal-organic frameworks that are topologically isomorphic with zeolites.
32599236	7	65	theme	CMC/ZSM-5/ZIF-8	1308:1322	arg1	adsorbents					1324:1333	CMC/ZSM-5/ZIF-8 adsorbents	1308:1333	CMC/ZSM-5/ZIF-8 adsorbents	1308:1333	The equilibrium continuous adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 10.56, 11.87, 9.29, and 8.15 mg/g, respectively.
32599236	2	66	theme	bed	547:549	arg1	systems					551:557	batch and continuous fixed bed systems	520:557	batch and continuous fixed bed systems	520:557	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	2	67	from	removal	487:493	arg1	systems					551:557	batch and continuous fixed bed systems	520:557	batch and continuous fixed bed systems	520:557	In this study, bionanocomposites of carboxymethyl cellulose-based ZSM-5/zeolitic imidazolate framework (CMC/ZSM-5/ZIF-8) hollow beads with different compositions were synthesized and employed as an adsorbent for methylene blue removal from aqueous solution in batch and continuous fixed bed systems.
32599236	7	68	theme	adsorption	1251:1260	arg1	10.56					1340:1344	10.56	1340:1344	10.56	1340:1344	The equilibrium continuous adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 10.56, 11.87, 9.29, and 8.15 mg/g, respectively.
32599236	7	68	theme	adsorption	1251:1260	arg1	capacities					1262:1271	The equilibrium continuous adsorption capacities	1224:1271	The equilibrium continuous adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents	1224:1333	The equilibrium continuous adsorption capacities for CMC, CMC/ZIF-8, CMC/ZSM-5, and CMC/ZSM-5/ZIF-8 adsorbents were 10.56, 11.87, 9.29, and 8.15 mg/g, respectively.
32599236	1	69	with	isomorphic	234:243	arg1	zeolites					250:257	zeolites	250:257	zeolites	250:257	Zeolitic imidazolate frameworks are a class of metal-organic frameworks that are topologically isomorphic with zeolites.
32599236	1	70	theme	imidazolate	148:158	arg1	frameworks					160:169	Zeolitic imidazolate frameworks	139:169	Zeolitic imidazolate frameworks	139:169	Zeolitic imidazolate frameworks are a class of metal-organic frameworks that are topologically isomorphic with zeolites.
32599236	1	70	theme	imidazolate	148:158	arg1	class					177:181	a class	175:181	a class of metal-organic frameworks that are topologically isomorphic with zeolites	175:257	Zeolitic imidazolate frameworks are a class of metal-organic frameworks that are topologically isomorphic with zeolites.
32599236	8	71	theme	Dose	1638:1641	arg1	Response					1643:1650	Modified Dose Response	1629:1650	Modified Dose Response	1629:1650	The continuous adsorption was investigated by Thomas, Adam-Bohart, Yoon-Nelson, Wolborska, and Modified Dose Response kinetic models and the results showed that the adsorbents showed more consistency with models of Thomas, Yoon-Nelson, and Modified Dose Response.
33541662	7	0	theme	chitosan	1156:1163	arg1	sample					1165:1170	the protiated chitosan sample	1142:1170	the protiated chitosan sample	1142:1170	The most abundant radii of the protiated and deuterated chitosan fibers were 54 Å and 60 Å, respectively, but there is a broader distribution of fiber radii in the protiated chitosan sample.
33541662	0	1	from	characterization	17:32	arg1	yeast					83:87	yeast	83:87	yeast	83:87	Biosynthesis and characterization of deuterated chitosan in filamentous fungus and yeast.
33541662	0	1	from	characterization	17:32	arg1	fungus					72:77	filamentous fungus	60:77	filamentous fungus	60:77	Biosynthesis and characterization of deuterated chitosan in filamentous fungus and yeast.
33541662	2	2	theme	infrared	387:394	arg1	FTIR					410:413	FTIR	410:413	FTIR	410:413	After extraction and purification, the chemical composition and structure were determined by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS).
33541662	2	2	theme	infrared	387:394	arg1	spectroscopy					396:407	Fourier-transform infrared spectroscopy	369:407	Fourier-transform infrared spectroscopy (FTIR)	369:414	After extraction and purification, the chemical composition and structure were determined by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS).
33541662	1	3	theme	chemical	252:259	arg1	deacetylation					261:273	conventional chemical deacetylation	239:273	conventional chemical deacetylation	239:273	Deuterated chitosan was produced from the filamentous fungus Rhizopus oryzae, cultivated with deuterated glucose in H2O medium, without the need for conventional chemical deacetylation.
33541662	9	4	theme	drug	1656:1659	arg1	delivery					1661:1668	drug delivery	1656:1668	drug delivery	1656:1668	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	2	5	theme	Fourier-transform	369:385	arg1	FTIR					410:413	FTIR	410:413	FTIR	410:413	After extraction and purification, the chemical composition and structure were determined by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS).
33541662	2	5	theme	Fourier-transform	369:385	arg1	spectroscopy					396:407	Fourier-transform infrared spectroscopy	369:407	Fourier-transform infrared spectroscopy (FTIR)	369:414	After extraction and purification, the chemical composition and structure were determined by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS).
33541662	3	6	from	position	556:563	arg1	backbone					602:609	the glucoseamine backbone	585:609	the glucoseamine backbone	585:609	13C NMR experiments provided additional information about the position of the deuterons in the glucoseamine backbone.
33541662	8	7	theme	scattering	1325:1334	arg1	studies					1336:1342	future neutron scattering studies	1310:1342	future neutron scattering studies	1310:1342	The highly deuterated, soluble fungal chitosan described here can be used as a model material for studying chitosan-enzyme complexes for future neutron scattering studies.
33541662	0	8	from	Biosynthesis	0:11	arg1	yeast					83:87	yeast	83:87	yeast	83:87	Biosynthesis and characterization of deuterated chitosan in filamentous fungus and yeast.
33541662	0	8	from	Biosynthesis	0:11	arg1	fungus					72:77	filamentous fungus	60:77	filamentous fungus	60:77	Biosynthesis and characterization of deuterated chitosan in filamentous fungus and yeast.
33541662	8	9	theme	chitosan-enzyme	1280:1294	arg1	complexes					1296:1304	chitosan-enzyme complexes	1280:1304	chitosan-enzyme complexes for future neutron scattering studies	1280:1342	The highly deuterated, soluble fungal chitosan described here can be used as a model material for studying chitosan-enzyme complexes for future neutron scattering studies.
33541662	1	10	dep	filamentous	132:142	arg1	fungus					144:149	fungus	144:149	fungus	144:149	Deuterated chitosan was produced from the filamentous fungus Rhizopus oryzae, cultivated with deuterated glucose in H2O medium, without the need for conventional chemical deacetylation.
33541662	4	11	theme	non-exchangeable	678:693	arg1	positions					704:712	the non-exchangeable hydrogen positions	674:712	the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring	674:744	The NMR spectra indicated that the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions was at least 60-80 %.
33541662	6	12	theme	non-deuterated	954:967	arg1	counterpart					969:979	the non-deuterated counterpart	950:979	the non-deuterated counterpart	950:979	Also, SANS showed that the structure of deuterated chitosan was very similar compared to the non-deuterated counterpart.
33541662	7	13	theme	protiated	1146:1154	arg1	sample					1165:1170	the protiated chitosan sample	1142:1170	the protiated chitosan sample	1142:1170	The most abundant radii of the protiated and deuterated chitosan fibers were 54 Å and 60 Å, respectively, but there is a broader distribution of fiber radii in the protiated chitosan sample.
33541662	9	14	theme	shrimp	1426:1431	arg1	chitosan					1439:1446	shrimp shell chitosan	1426:1446	shrimp shell chitosan	1426:1446	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	4	15	theme	ring	741:744	arg1	positions					704:712	the non-exchangeable hydrogen positions	674:712	the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring	674:744	The NMR spectra indicated that the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions was at least 60-80 %.
33541662	4	16	from	positions	704:712	arg1	incorporation					657:669	the deuterium incorporation	643:669	the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions	643:769	The NMR spectra indicated that the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions was at least 60-80 %.
33541662	4	16	from	positions	704:712	arg1	%					790:790	at least 60-80 %	775:790	at least 60-80 %	775:790	The NMR spectra indicated that the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions was at least 60-80 %.
33541662	9	17	theme	fungal	1393:1398	arg1	chitosan					1400:1407	non-deuterated fungal chitosan	1378:1407	non-deuterated fungal chitosan	1378:1407	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	4	18	theme	aminoglucopyranosyl	721:739	arg1	ring					741:744	the aminoglucopyranosyl ring	717:744	the aminoglucopyranosyl ring	717:744	The NMR spectra indicated that the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions was at least 60-80 %.
33541662	7	19	from	distribution	1111:1122	arg1	sample					1165:1170	the protiated chitosan sample	1142:1170	the protiated chitosan sample	1142:1170	The most abundant radii of the protiated and deuterated chitosan fibers were 54 Å and 60 Å, respectively, but there is a broader distribution of fiber radii in the protiated chitosan sample.
33541662	9	20	theme	tissue	1671:1676	arg1	engineering					1678:1688	tissue engineering	1671:1688	tissue engineering	1671:1688	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	8	21	theme	fungal	1204:1209	arg1	chitosan					1211:1218	The highly deuterated, soluble fungal chitosan	1173:1218	The highly deuterated, soluble fungal chitosan described here	1173:1233	The highly deuterated, soluble fungal chitosan described here can be used as a model material for studying chitosan-enzyme complexes for future neutron scattering studies.
33541662	8	21	theme	fungal	1204:1209	arg1	material					1258:1265	a model material	1250:1265	a model material for studying chitosan-enzyme complexes for future neutron scattering studies	1250:1342	The highly deuterated, soluble fungal chitosan described here can be used as a model material for studying chitosan-enzyme complexes for future neutron scattering studies.
33541662	2	22	theme	nuclear	417:423	arg1	resonance					434:442	nuclear magnetic resonance	417:442	nuclear magnetic resonance (NMR)	417:448	After extraction and purification, the chemical composition and structure were determined by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS).
33541662	2	22	theme	nuclear	417:423	arg1	NMR					445:447	NMR	445:447	NMR	445:447	After extraction and purification, the chemical composition and structure were determined by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS).
33541662	5	23	theme	C2	806:807	arg1	position					809:816	the C2 position	802:816	the C2 position	802:816	However, the C2 position was deuterated at a much lower level (6%).
33541662	9	24	theme	high	1516:1519	arg1	aminopolysaccharide					1559:1577	a high quality deuterated non-animal-derived aminopolysaccharide	1514:1577	a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites	1514:1734	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	9	25	from	association	1615:1625	arg1	composites					1725:1734	other bioactive chitosan-based composites	1694:1734	other bioactive chitosan-based composites	1694:1734	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	9	25	from	association	1615:1625	arg1	delivery					1661:1668	drug delivery	1656:1668	drug delivery	1656:1668	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	9	25	from	association	1615:1625	arg1	engineering					1678:1688	tissue engineering	1671:1688	tissue engineering	1671:1688	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	1	26	theme	deuterated	184:193	arg1	glucose					195:201	deuterated glucose	184:201	deuterated glucose	184:201	Deuterated chitosan was produced from the filamentous fungus Rhizopus oryzae, cultivated with deuterated glucose in H2O medium, without the need for conventional chemical deacetylation.
33541662	2	27	theme	small-angle	455:465	arg1	scattering					475:484	small-angle neutron scattering	455:484	small-angle neutron scattering (SANS)	455:491	After extraction and purification, the chemical composition and structure were determined by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS).
33541662	2	27	theme	small-angle	455:465	arg1	SANS					487:490	SANS	487:490	SANS	487:490	After extraction and purification, the chemical composition and structure were determined by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS).
33541662	9	28	theme	new	1488:1490	arg1	approach					1492:1499	a new approach	1486:1499	a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites	1486:1734	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	1	29	theme	Deuterated	90:99	arg1	chitosan					101:108	Deuterated chitosan	90:108	Deuterated chitosan	90:108	Deuterated chitosan was produced from the filamentous fungus Rhizopus oryzae, cultivated with deuterated glucose in H2O medium, without the need for conventional chemical deacetylation.
33541662	9	30	theme	shell	1433:1437	arg1	chitosan					1439:1446	shrimp shell chitosan	1426:1446	shrimp shell chitosan	1426:1446	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	7	31	theme	fiber	1127:1131	arg1	radii					1133:1137	fiber radii	1127:1137	fiber radii	1127:1137	The most abundant radii of the protiated and deuterated chitosan fibers were 54 Å and 60 Å, respectively, but there is a broader distribution of fiber radii in the protiated chitosan sample.
33541662	8	32	theme	deuterated	1184:1193	arg1	chitosan					1211:1218	The highly deuterated, soluble fungal chitosan	1173:1218	The highly deuterated, soluble fungal chitosan described here	1173:1233	The highly deuterated, soluble fungal chitosan described here can be used as a model material for studying chitosan-enzyme complexes for future neutron scattering studies.
33541662	8	32	theme	deuterated	1184:1193	arg1	material					1258:1265	a model material	1250:1265	a model material for studying chitosan-enzyme complexes for future neutron scattering studies	1250:1342	The highly deuterated, soluble fungal chitosan described here can be used as a model material for studying chitosan-enzyme complexes for future neutron scattering studies.
33541662	4	33	theme	C5	758:759	arg1	positions					761:769	the C3 - C5 positions	749:769	the C3 - C5 positions	749:769	The NMR spectra indicated that the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions was at least 60-80 %.
33541662	4	34	theme	hydrogen	695:702	arg1	positions					704:712	the non-exchangeable hydrogen positions	674:712	the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring	674:744	The NMR spectra indicated that the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions was at least 60-80 %.
33541662	7	35	theme	broader	1103:1109	arg1	distribution					1111:1122	a broader distribution	1101:1122	a broader distribution of fiber radii in the protiated chitosan sample	1101:1170	The most abundant radii of the protiated and deuterated chitosan fibers were 54 Å and 60 Å, respectively, but there is a broader distribution of fiber radii in the protiated chitosan sample.
33541662	7	36	theme	fibers	1047:1052	arg1	Å					1062:1062	54 Å and 60 Å	1059:1071	Å	1062:1062	The most abundant radii of the protiated and deuterated chitosan fibers were 54 Å and 60 Å, respectively, but there is a broader distribution of fiber radii in the protiated chitosan sample.
33541662	7	36	theme	fibers	1047:1052	arg1	radii					1000:1004	The most abundant radii	982:1004	The most abundant radii of the protiated and deuterated chitosan fibers	982:1052	The most abundant radii of the protiated and deuterated chitosan fibers were 54 Å and 60 Å, respectively, but there is a broader distribution of fiber radii in the protiated chitosan sample.
33541662	9	37	theme	chitosan	1400:1407	arg1	behavior					1366:1373	the physical behavior	1353:1373	the physical behavior of non-deuterated fungal chitosan	1353:1407	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	2	38	theme	chemical	315:322	arg1	composition					324:334	the chemical composition	311:334	the chemical composition	311:334	After extraction and purification, the chemical composition and structure were determined by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS).
33541662	4	39	from	incorporation	657:669	arg1	positions					761:769	the C3 - C5 positions	749:769	the C3 - C5 positions	749:769	The NMR spectra indicated that the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions was at least 60-80 %.
33541662	1	40	theme	H2O	206:208	arg1	medium					210:215	H2O medium	206:215	H2O medium	206:215	Deuterated chitosan was produced from the filamentous fungus Rhizopus oryzae, cultivated with deuterated glucose in H2O medium, without the need for conventional chemical deacetylation.
33541662	8	41	theme	neutron	1317:1323	arg1	scattering					1325:1334	future neutron scattering	1310:1334	future neutron scattering studies	1310:1342	The highly deuterated, soluble fungal chitosan described here can be used as a model material for studying chitosan-enzyme complexes for future neutron scattering studies.
33541662	9	42	theme	chitosan-based	1710:1723	arg1	composites					1725:1734	other bioactive chitosan-based composites	1694:1734	other bioactive chitosan-based composites	1694:1734	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	3	43	theme	deuterons	572:580	arg1	position					556:563	the position	552:563	the position of the deuterons in the glucoseamine backbone	552:609	13C NMR experiments provided additional information about the position of the deuterons in the glucoseamine backbone.
33541662	3	44	theme	additional	523:532	arg1	information					534:544	additional information	523:544	additional information about the position of the deuterons in the glucoseamine backbone	523:609	13C NMR experiments provided additional information about the position of the deuterons in the glucoseamine backbone.
33541662	0	45	theme	chitosan	48:55	arg1	characterization					17:32	characterization	17:32	characterization	17:32	Biosynthesis and characterization of deuterated chitosan in filamentous fungus and yeast.
33541662	0	45	theme	chitosan	48:55	arg1	Biosynthesis					0:11	Biosynthesis	0:11	Biosynthesis	0:11	Biosynthesis and characterization of deuterated chitosan in filamentous fungus and yeast.
33541662	9	46	theme	quality	1521:1527	arg1	aminopolysaccharide					1559:1577	a high quality deuterated non-animal-derived aminopolysaccharide	1514:1577	a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites	1514:1734	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	7	47	theme	deuterated	1027:1036	arg1	fibers					1047:1052	the protiated and deuterated chitosan fibers	1009:1052	the protiated and deuterated chitosan fibers	1009:1052	The most abundant radii of the protiated and deuterated chitosan fibers were 54 Å and 60 Å, respectively, but there is a broader distribution of fiber radii in the protiated chitosan sample.
33541662	9	48	theme	other	1694:1698	arg1	composites					1725:1734	other bioactive chitosan-based composites	1694:1734	other bioactive chitosan-based composites	1694:1734	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	8	49	used	used	1242:1245	arg2	chitosan					1211:1218	The highly deuterated, soluble fungal chitosan	1173:1218	The highly deuterated, soluble fungal chitosan described here	1173:1233	The highly deuterated, soluble fungal chitosan described here can be used as a model material for studying chitosan-enzyme complexes for future neutron scattering studies.
33541662	8	49	used	used	1242:1245	arg2	material					1258:1265	a model material	1250:1265	a model material for studying chitosan-enzyme complexes for future neutron scattering studies	1250:1342	The highly deuterated, soluble fungal chitosan described here can be used as a model material for studying chitosan-enzyme complexes for future neutron scattering studies.
33541662	5	50	theme	lower	843:847	arg1	level					849:853	a much lower level	836:853	a much lower level (6%)	836:858	However, the C2 position was deuterated at a much lower level (6%).
33541662	5	50	theme	lower	843:847	arg1	%					857:857	6%	856:857	6%	856:857	However, the C2 position was deuterated at a much lower level (6%).
33541662	0	51	theme	deuterated	37:46	arg1	chitosan					48:55	deuterated chitosan	37:55	deuterated chitosan	37:55	Biosynthesis and characterization of deuterated chitosan in filamentous fungus and yeast.
33541662	7	52	theme	chitosan	1038:1045	arg1	fibers					1047:1052	the protiated and deuterated chitosan fibers	1009:1052	the protiated and deuterated chitosan fibers	1009:1052	The most abundant radii of the protiated and deuterated chitosan fibers were 54 Å and 60 Å, respectively, but there is a broader distribution of fiber radii in the protiated chitosan sample.
33541662	7	53	theme	abundant	991:998	arg1	Å					1062:1062	54 Å and 60 Å	1059:1071	Å	1062:1062	The most abundant radii of the protiated and deuterated chitosan fibers were 54 Å and 60 Å, respectively, but there is a broader distribution of fiber radii in the protiated chitosan sample.
33541662	7	53	theme	abundant	991:998	arg1	radii					1000:1004	The most abundant radii	982:1004	The most abundant radii of the protiated and deuterated chitosan fibers	982:1052	The most abundant radii of the protiated and deuterated chitosan fibers were 54 Å and 60 Å, respectively, but there is a broader distribution of fiber radii in the protiated chitosan sample.
33541662	2	54	theme	magnetic	425:432	arg1	resonance					434:442	nuclear magnetic resonance	417:442	nuclear magnetic resonance (NMR)	417:448	After extraction and purification, the chemical composition and structure were determined by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS).
33541662	2	54	theme	magnetic	425:432	arg1	NMR					445:447	NMR	445:447	NMR	445:447	After extraction and purification, the chemical composition and structure were determined by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS).
33541662	0	55	theme	filamentous	60:70	arg1	fungus					72:77	filamentous fungus	60:77	filamentous fungus	60:77	Biosynthesis and characterization of deuterated chitosan in filamentous fungus and yeast.
33541662	6	56	theme	chitosan	912:919	arg1	similar					930:936	similar	930:936	similar	930:936	Also, SANS showed that the structure of deuterated chitosan was very similar compared to the non-deuterated counterpart.
33541662	6	56	theme	chitosan	912:919	arg1	structure					888:896	the structure	884:896	the structure of deuterated chitosan	884:919	Also, SANS showed that the structure of deuterated chitosan was very similar compared to the non-deuterated counterpart.
33541662	7	57	theme	protiated	1013:1021	arg1	fibers					1047:1052	the protiated and deuterated chitosan fibers	1009:1052	the protiated and deuterated chitosan fibers	1009:1052	The most abundant radii of the protiated and deuterated chitosan fibers were 54 Å and 60 Å, respectively, but there is a broader distribution of fiber radii in the protiated chitosan sample.
33541662	9	58	theme	non-animal-derived	1540:1557	arg1	aminopolysaccharide					1559:1577	a high quality deuterated non-animal-derived aminopolysaccharide	1514:1577	a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites	1514:1734	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	3	59	theme	glucoseamine	589:600	arg1	backbone					602:609	the glucoseamine backbone	585:609	the glucoseamine backbone	585:609	13C NMR experiments provided additional information about the position of the deuterons in the glucoseamine backbone.
33541662	8	60	theme	future	1310:1315	arg1	scattering					1325:1334	future neutron scattering	1310:1334	future neutron scattering studies	1310:1342	The highly deuterated, soluble fungal chitosan described here can be used as a model material for studying chitosan-enzyme complexes for future neutron scattering studies.
33541662	3	61	theme	13C	494:496	arg1	experiments					502:512	13C NMR experiments	494:512	13C NMR experiments	494:512	13C NMR experiments provided additional information about the position of the deuterons in the glucoseamine backbone.
33541662	2	62	theme	neutron	467:473	arg1	scattering					475:484	small-angle neutron scattering	455:484	small-angle neutron scattering (SANS)	455:491	After extraction and purification, the chemical composition and structure were determined by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS).
33541662	2	62	theme	neutron	467:473	arg1	SANS					487:490	SANS	487:490	SANS	487:490	After extraction and purification, the chemical composition and structure were determined by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and small-angle neutron scattering (SANS).
33541662	6	63	theme	deuterated	901:910	arg1	chitosan					912:919	deuterated chitosan	901:919	deuterated chitosan	901:919	Also, SANS showed that the structure of deuterated chitosan was very similar compared to the non-deuterated counterpart.
33541662	9	64	theme	bioactive	1700:1708	arg1	composites					1725:1734	other bioactive chitosan-based composites	1694:1734	other bioactive chitosan-based composites	1694:1734	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	9	65	theme	structure-function	1596:1613	arg1	association					1615:1625	the structure-function association	1592:1625	the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites	1592:1734	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	3	66	theme	NMR	498:500	arg1	experiments					502:512	13C NMR experiments	494:512	13C NMR experiments	494:512	13C NMR experiments provided additional information about the position of the deuterons in the glucoseamine backbone.
33541662	1	67	theme	filamentous	132:142	arg1	oryzae					160:165	the filamentous fungus Rhizopus oryzae	128:165	the filamentous fungus Rhizopus oryzae	128:165	Deuterated chitosan was produced from the filamentous fungus Rhizopus oryzae, cultivated with deuterated glucose in H2O medium, without the need for conventional chemical deacetylation.
33541662	8	68	dep	deuterated	1184:1193	arg1	soluble					1196:1202	soluble	1196:1202	soluble	1196:1202	The highly deuterated, soluble fungal chitosan described here can be used as a model material for studying chitosan-enzyme complexes for future neutron scattering studies.
33541662	8	69	theme	model	1252:1256	arg1	chitosan					1211:1218	The highly deuterated, soluble fungal chitosan	1173:1218	The highly deuterated, soluble fungal chitosan described here	1173:1233	The highly deuterated, soluble fungal chitosan described here can be used as a model material for studying chitosan-enzyme complexes for future neutron scattering studies.
33541662	8	69	theme	model	1252:1256	arg1	material					1258:1265	a model material	1250:1265	a model material for studying chitosan-enzyme complexes for future neutron scattering studies	1250:1342	The highly deuterated, soluble fungal chitosan described here can be used as a model material for studying chitosan-enzyme complexes for future neutron scattering studies.
33541662	4	70	theme	C3	753:754	arg1	positions					761:769	the C3 - C5 positions	749:769	the C3 - C5 positions	749:769	The NMR spectra indicated that the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions was at least 60-80 %.
33541662	4	71	theme	NMR	616:618	arg1	spectra					620:626	The NMR spectra	612:626	The NMR spectra	612:626	The NMR spectra indicated that the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions was at least 60-80 %.
33541662	9	72	link	non-animal-derived	1540:1557	arg1	aminopolysaccharide					1559:1577	a high quality deuterated non-animal-derived aminopolysaccharide	1514:1577	a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites	1514:1734	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	9	73	theme	biocomposite	1630:1641	arg1	materials					1643:1651	biocomposite materials	1630:1651	biocomposite materials	1630:1651	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	4	74	theme	deuterium	647:655	arg1	incorporation					657:669	the deuterium incorporation	643:669	the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions	643:769	The NMR spectra indicated that the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions was at least 60-80 %.
33541662	4	74	theme	deuterium	647:655	arg1	%					790:790	at least 60-80 %	775:790	at least 60-80 %	775:790	The NMR spectra indicated that the deuterium incorporation at the non-exchangeable hydrogen positions of the aminoglucopyranosyl ring in the C3 - C5 positions was at least 60-80 %.
33541662	1	75	theme	Rhizopus	151:158	arg1	oryzae					160:165	the filamentous fungus Rhizopus oryzae	128:165	the filamentous fungus Rhizopus oryzae	128:165	Deuterated chitosan was produced from the filamentous fungus Rhizopus oryzae, cultivated with deuterated glucose in H2O medium, without the need for conventional chemical deacetylation.
33541662	9	76	theme	deuterated	1529:1538	arg1	aminopolysaccharide					1559:1577	a high quality deuterated non-animal-derived aminopolysaccharide	1514:1577	a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites	1514:1734	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	9	77	theme	non-deuterated	1378:1391	arg1	chitosan					1400:1407	non-deuterated fungal chitosan	1378:1407	non-deuterated fungal chitosan	1378:1407	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	7	78	theme	radii	1133:1137	arg1	distribution					1111:1122	a broader distribution	1101:1122	a broader distribution of fiber radii in the protiated chitosan sample	1101:1170	The most abundant radii of the protiated and deuterated chitosan fibers were 54 Å and 60 Å, respectively, but there is a broader distribution of fiber radii in the protiated chitosan sample.
33541662	9	79	theme	materials	1643:1651	arg1	association					1615:1625	the structure-function association	1592:1625	the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites	1592:1734	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	9	80	theme	physical	1357:1364	arg1	behavior					1366:1373	the physical behavior	1353:1373	the physical behavior of non-deuterated fungal chitosan	1353:1407	Because the physical behavior of non-deuterated fungal chitosan mimicked that of shrimp shell chitosan, the methods presented here represent a new approach to producing a high quality deuterated non-animal-derived aminopolysaccharide for studying the structure-function association of biocomposite materials in drug delivery, tissue engineering and other bioactive chitosan-based composites.
33541662	1	81	theme	conventional	239:250	arg1	deacetylation					261:273	conventional chemical deacetylation	239:273	conventional chemical deacetylation	239:273	Deuterated chitosan was produced from the filamentous fungus Rhizopus oryzae, cultivated with deuterated glucose in H2O medium, without the need for conventional chemical deacetylation.
32541122	4	0	contain	has	612:614	arg1	CSH					608:610	CSH	608:610	CSH	608:610	Results revealed that CSH has outstanding stability in strong acid solution, thus extending the useful pH range as an adsorbent material.
32541122	4	0	contain	has	612:614	arg2	stability					628:636	outstanding stability	616:636	outstanding stability	616:636	Results revealed that CSH has outstanding stability in strong acid solution, thus extending the useful pH range as an adsorbent material.
32541122	2	1	theme	physical	314:321	arg1	properties					336:345	The physical and chemical properties	310:345	The physical and chemical properties	310:345	The physical and chemical properties of CSH, such as acid resistance and swelling, were determined.
32541122	2	1	theme	physical	314:321	arg1	swelling					383:390	swelling	383:390	swelling	383:390	The physical and chemical properties of CSH, such as acid resistance and swelling, were determined.
32541122	2	1	theme	physical	314:321	arg1	resistance					368:377	acid resistance	363:377	acid resistance	363:377	The physical and chemical properties of CSH, such as acid resistance and swelling, were determined.
32541122	6	2	theme	Cu	988:989	arg1	adsorption					974:983	the adsorption	970:983	the adsorption of Cu(II) on CSH	970:1000	The adsorption process was best described by a pseudo-second-order kinetic model, while isotherm modeling revealed that the Langmuir equation better described the adsorption of Cu(II) on CSH.
32541122	0	3	theme	ions	84:87	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of cross-linking chitosan-PVA composite hydrogel	0:57	Synthesis of cross-linking chitosan-PVA composite hydrogel and adsorption of Cu(II) ions.
32541122	0	3	theme	ions	84:87	arg1	adsorption					63:72	adsorption	63:72	adsorption of Cu(II) ions	63:87	Synthesis of cross-linking chitosan-PVA composite hydrogel and adsorption of Cu(II) ions.
32541122	7	4	dep	five	1134:1137	arg1	to					1131:1132	to	1131:1132	to	1131:1132	Moreover, the loaded CSH can be easily regenerated by the HCl-washing method and reused repeatedly for Cu(II) adsorption for up to five cycles.
32541122	3	5	theme	ion	426:428	arg1	removal					430:436	Cu(II) ion removal	419:436	Cu(II) ion removal by the CSH	419:447	Finally, Cu(II) ion removal by the CSH was investigated, and the effects of experimental parameters, including pH, adsorption time, and regeneration performance were examined.
32541122	1	6	theme	scanning	246:253	arg1	SEM					276:278	SEM	276:278	SEM	276:278	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	1	6	theme	scanning	246:253	arg1	microscopy					264:273	scanning electron microscopy	246:273	scanning electron microscopy (SEM)	246:279	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	7	7	theme	loaded	1017:1022	arg1	CSH					1024:1026	the loaded CSH	1013:1026	the loaded CSH	1013:1026	Moreover, the loaded CSH can be easily regenerated by the HCl-washing method and reused repeatedly for Cu(II) adsorption for up to five cycles.
32541122	7	8	theme	Cu	1106:1107	arg1	adsorption					1113:1122	Cu(II) adsorption	1106:1122	Cu(II) adsorption	1106:1122	Moreover, the loaded CSH can be easily regenerated by the HCl-washing method and reused repeatedly for Cu(II) adsorption for up to five cycles.
32541122	6	9	theme	isotherm	899:906	arg1	modeling					908:915	isotherm modeling	899:915	isotherm modeling	899:915	The adsorption process was best described by a pseudo-second-order kinetic model, while isotherm modeling revealed that the Langmuir equation better described the adsorption of Cu(II) on CSH.
32541122	4	10	theme	pH	689:690	arg1	range					692:696	the useful pH range	678:696	the useful pH range	678:696	Results revealed that CSH has outstanding stability in strong acid solution, thus extending the useful pH range as an adsorbent material.
32541122	4	10	theme	pH	689:690	arg1	material					714:721	an adsorbent material	701:721	an adsorbent material	701:721	Results revealed that CSH has outstanding stability in strong acid solution, thus extending the useful pH range as an adsorbent material.
32541122	6	11	theme	Langmuir	935:942	arg1	equation					944:951	the Langmuir equation	931:951	the Langmuir equation	931:951	The adsorption process was best described by a pseudo-second-order kinetic model, while isotherm modeling revealed that the Langmuir equation better described the adsorption of Cu(II) on CSH.
32541122	4	12	theme	useful	682:687	arg1	range					692:696	the useful pH range	678:696	the useful pH range	678:696	Results revealed that CSH has outstanding stability in strong acid solution, thus extending the useful pH range as an adsorbent material.
32541122	4	12	theme	useful	682:687	arg1	material					714:721	an adsorbent material	701:721	an adsorbent material	701:721	Results revealed that CSH has outstanding stability in strong acid solution, thus extending the useful pH range as an adsorbent material.
32541122	2	13	theme	CSH	350:352	arg1	properties					336:345	The physical and chemical properties	310:345	The physical and chemical properties	310:345	The physical and chemical properties of CSH, such as acid resistance and swelling, were determined.
32541122	2	13	theme	CSH	350:352	arg1	swelling					383:390	swelling	383:390	swelling	383:390	The physical and chemical properties of CSH, such as acid resistance and swelling, were determined.
32541122	2	13	theme	CSH	350:352	arg1	resistance					368:377	acid resistance	363:377	acid resistance	363:377	The physical and chemical properties of CSH, such as acid resistance and swelling, were determined.
32541122	1	14	theme	electron	255:262	arg1	SEM					276:278	SEM	276:278	SEM	276:278	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	1	14	theme	electron	255:262	arg1	microscopy					264:273	scanning electron microscopy	246:273	scanning electron microscopy (SEM)	246:279	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	4	15	theme	acid	648:651	arg1	solution					653:660	strong acid solution	641:660	strong acid solution	641:660	Results revealed that CSH has outstanding stability in strong acid solution, thus extending the useful pH range as an adsorbent material.
32541122	0	16	theme	chitosan-PVA	27:38	arg1	hydrogel					50:57	cross-linking chitosan-PVA composite hydrogel	13:57	cross-linking chitosan-PVA composite hydrogel	13:57	Synthesis of cross-linking chitosan-PVA composite hydrogel and adsorption of Cu(II) ions.
32541122	6	17	theme	adsorption	815:824	arg1	process					826:832	The adsorption process	811:832	The adsorption process	811:832	The adsorption process was best described by a pseudo-second-order kinetic model, while isotherm modeling revealed that the Langmuir equation better described the adsorption of Cu(II) on CSH.
32541122	0	18	theme	cross-linking	13:25	arg1	hydrogel					50:57	cross-linking chitosan-PVA composite hydrogel	13:57	cross-linking chitosan-PVA composite hydrogel	13:57	Synthesis of cross-linking chitosan-PVA composite hydrogel and adsorption of Cu(II) ions.
32541122	3	19	theme	regeneration	546:557	arg1	performance					559:569	regeneration performance	546:569	regeneration performance	546:569	Finally, Cu(II) ion removal by the CSH was investigated, and the effects of experimental parameters, including pH, adsorption time, and regeneration performance were examined.
32541122	2	20	theme	acid	363:366	arg1	resistance					368:377	acid resistance	363:377	acid resistance	363:377	The physical and chemical properties of CSH, such as acid resistance and swelling, were determined.
32541122	0	21	theme	hydrogel	50:57	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of cross-linking chitosan-PVA composite hydrogel	0:57	Synthesis of cross-linking chitosan-PVA composite hydrogel and adsorption of Cu(II) ions.
32541122	0	21	theme	hydrogel	50:57	arg1	adsorption					63:72	adsorption	63:72	adsorption of Cu(II) ions	63:87	Synthesis of cross-linking chitosan-PVA composite hydrogel and adsorption of Cu(II) ions.
32541122	4	22	theme	outstanding	616:626	arg1	stability					628:636	outstanding stability	616:636	outstanding stability	616:636	Results revealed that CSH has outstanding stability in strong acid solution, thus extending the useful pH range as an adsorbent material.
32541122	5	23	theme	CSH	748:750	arg1	mg/g					787:790	62.1 mg/g	782:790	62.1 mg/g at 25 °C for 24 h	782:808	The maximum capacity of CSH for Cu(II) was obtained to be 62.1 mg/g at 25 °C for 24 h.
32541122	5	23	theme	CSH	748:750	arg1	capacity					736:743	The maximum capacity	724:743	The maximum capacity of CSH for Cu(II)	724:761	The maximum capacity of CSH for Cu(II) was obtained to be 62.1 mg/g at 25 °C for 24 h.
32541122	0	24	theme	composite	40:48	arg1	hydrogel					50:57	cross-linking chitosan-PVA composite hydrogel	13:57	cross-linking chitosan-PVA composite hydrogel	13:57	Synthesis of cross-linking chitosan-PVA composite hydrogel and adsorption of Cu(II) ions.
32541122	1	25	dep	transform	206:214	arg1	infrared					216:223	infrared	216:223	transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD)	206:307	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	3	26	theme	experimental	486:497	arg1	performance					559:569	regeneration performance	546:569	regeneration performance	546:569	Finally, Cu(II) ion removal by the CSH was investigated, and the effects of experimental parameters, including pH, adsorption time, and regeneration performance were examined.
32541122	3	26	theme	experimental	486:497	arg1	parameters					499:508	experimental parameters	486:508	experimental parameters	486:508	Finally, Cu(II) ion removal by the CSH was investigated, and the effects of experimental parameters, including pH, adsorption time, and regeneration performance were examined.
32541122	3	26	theme	experimental	486:497	arg1	pH					521:522	pH	521:522	pH	521:522	Finally, Cu(II) ion removal by the CSH was investigated, and the effects of experimental parameters, including pH, adsorption time, and regeneration performance were examined.
32541122	3	26	theme	experimental	486:497	arg1	time					536:539	adsorption time	525:539	adsorption time	525:539	Finally, Cu(II) ion removal by the CSH was investigated, and the effects of experimental parameters, including pH, adsorption time, and regeneration performance were examined.
32541122	6	27	from	adsorption	974:983	arg1	CSH					998:1000	CSH	998:1000	CSH	998:1000	The adsorption process was best described by a pseudo-second-order kinetic model, while isotherm modeling revealed that the Langmuir equation better described the adsorption of Cu(II) on CSH.
32541122	1	28	theme	cross-linked	92:103	arg1	CSH					138:140	CSH	138:140	CSH	138:140	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	1	28	theme	cross-linked	92:103	arg1	hydrogel					128:135	A cross-linked chitosan-PVA spherical hydrogel	90:135	A cross-linked chitosan-PVA spherical hydrogel (CSH)	90:141	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	1	29	theme	X-ray	285:289	arg1	XRD					304:306	XRD	304:306	XRD	304:306	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	1	29	theme	X-ray	285:289	arg1	diffraction					291:301	X-ray diffraction	285:301	X-ray diffraction (XRD)	285:307	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	3	30	theme	parameters	499:508	arg1	effects					475:481	the effects	471:481	the effects of experimental parameters, including pH, adsorption time, and regeneration performance	471:569	Finally, Cu(II) ion removal by the CSH was investigated, and the effects of experimental parameters, including pH, adsorption time, and regeneration performance were examined.
32541122	1	31	theme	chitosan-PVA	105:116	arg1	CSH					138:140	CSH	138:140	CSH	138:140	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	1	31	theme	chitosan-PVA	105:116	arg1	hydrogel					128:135	A cross-linked chitosan-PVA spherical hydrogel	90:135	A cross-linked chitosan-PVA spherical hydrogel (CSH)	90:141	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	4	32	theme	strong	641:646	arg1	solution					653:660	strong acid solution	641:660	strong acid solution	641:660	Results revealed that CSH has outstanding stability in strong acid solution, thus extending the useful pH range as an adsorbent material.
32541122	1	33	link	cross-linked	92:103	arg1	CSH					138:140	CSH	138:140	CSH	138:140	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	1	33	link	cross-linked	92:103	arg1	hydrogel					128:135	A cross-linked chitosan-PVA spherical hydrogel	90:135	A cross-linked chitosan-PVA spherical hydrogel (CSH)	90:141	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	3	34	theme	adsorption	525:534	arg1	time					536:539	adsorption time	525:539	adsorption time	525:539	Finally, Cu(II) ion removal by the CSH was investigated, and the effects of experimental parameters, including pH, adsorption time, and regeneration performance were examined.
32541122	6	35	theme	kinetic	878:884	arg1	model					886:890	a pseudo-second-order kinetic model	856:890	a pseudo-second-order kinetic model	856:890	The adsorption process was best described by a pseudo-second-order kinetic model, while isotherm modeling revealed that the Langmuir equation better described the adsorption of Cu(II) on CSH.
32541122	1	36	theme	spherical	118:126	arg1	CSH					138:140	CSH	138:140	CSH	138:140	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	1	36	theme	spherical	118:126	arg1	hydrogel					128:135	A cross-linked chitosan-PVA spherical hydrogel	90:135	A cross-linked chitosan-PVA spherical hydrogel (CSH)	90:141	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	1	37	dep	Fourier	198:204	arg1	transform					206:214	transform	206:214	transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD)	206:307	A cross-linked chitosan-PVA spherical hydrogel (CSH) was synthesized and its structure was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD).
32541122	5	38	from	°C	798:799	arg1	mg/g					787:790	62.1 mg/g	782:790	62.1 mg/g at 25 °C for 24 h	782:808	The maximum capacity of CSH for Cu(II) was obtained to be 62.1 mg/g at 25 °C for 24 h.
32541122	5	38	from	°C	798:799	arg1	capacity					736:743	The maximum capacity	724:743	The maximum capacity of CSH for Cu(II)	724:761	The maximum capacity of CSH for Cu(II) was obtained to be 62.1 mg/g at 25 °C for 24 h.
32541122	3	39	theme	Cu	419:420	arg1	removal					430:436	Cu(II) ion removal	419:436	Cu(II) ion removal by the CSH	419:447	Finally, Cu(II) ion removal by the CSH was investigated, and the effects of experimental parameters, including pH, adsorption time, and regeneration performance were examined.
32541122	0	40	theme	Cu	77:78	arg1	ions					84:87	Cu(II) ions	77:87	Cu(II) ions	77:87	Synthesis of cross-linking chitosan-PVA composite hydrogel and adsorption of Cu(II) ions.
32541122	4	41	theme	adsorbent	704:712	arg1	range					692:696	the useful pH range	678:696	the useful pH range	678:696	Results revealed that CSH has outstanding stability in strong acid solution, thus extending the useful pH range as an adsorbent material.
32541122	4	41	theme	adsorbent	704:712	arg1	material					714:721	an adsorbent material	701:721	an adsorbent material	701:721	Results revealed that CSH has outstanding stability in strong acid solution, thus extending the useful pH range as an adsorbent material.
32541122	2	42	theme	chemical	327:334	arg1	properties					336:345	The physical and chemical properties	310:345	The physical and chemical properties	310:345	The physical and chemical properties of CSH, such as acid resistance and swelling, were determined.
32541122	2	42	theme	chemical	327:334	arg1	swelling					383:390	swelling	383:390	swelling	383:390	The physical and chemical properties of CSH, such as acid resistance and swelling, were determined.
32541122	2	42	theme	chemical	327:334	arg1	resistance					368:377	acid resistance	363:377	acid resistance	363:377	The physical and chemical properties of CSH, such as acid resistance and swelling, were determined.
32541122	6	43	theme	pseudo-second-order	858:876	arg1	model					886:890	a pseudo-second-order kinetic model	856:890	a pseudo-second-order kinetic model	856:890	The adsorption process was best described by a pseudo-second-order kinetic model, while isotherm modeling revealed that the Langmuir equation better described the adsorption of Cu(II) on CSH.
32541122	5	44	theme	maximum	728:734	arg1	mg/g					787:790	62.1 mg/g	782:790	62.1 mg/g at 25 °C for 24 h	782:808	The maximum capacity of CSH for Cu(II) was obtained to be 62.1 mg/g at 25 °C for 24 h.
32541122	5	44	theme	maximum	728:734	arg1	capacity					736:743	The maximum capacity	724:743	The maximum capacity of CSH for Cu(II)	724:761	The maximum capacity of CSH for Cu(II) was obtained to be 62.1 mg/g at 25 °C for 24 h.
32541122	7	45	theme	HCl-washing	1061:1071	arg1	method					1073:1078	the HCl-washing method	1057:1078	the HCl-washing method	1057:1078	Moreover, the loaded CSH can be easily regenerated by the HCl-washing method and reused repeatedly for Cu(II) adsorption for up to five cycles.
32521721	0	0	from	Study	14:18	arg1	Fe3+					41:44	Fe3+	41:44	Fe3+	41:44	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.
32521721	0	0	from	Study	14:18	arg1	Ni2+					35:38	Ni2+	35:38	Ni2+	35:38	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.
32521721	0	0	from	Study	14:18	arg1	Zn2+					29:32	Zn2+	29:32	Zn2+	29:32	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.
32521721	0	0	from	Study	14:18	arg1	Cu2+					23:26	Cu2+	23:26	Cu2+	23:26	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.
32521721	0	0	from	Study	14:18	arg1	Ions					62:65	Cr3+ Metal Ions	51:65	Cr3+ Metal Ions	51:65	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.
32521721	6	1	theme	composite	1235:1243	arg1	sorbent					1245:1251	the composite sorbent	1231:1251	the composite sorbent using dynamic technique	1231:1275	Based on the optimized sorption conditions, the removal of the above-mentioned ions from aqueous solutions by the composite sorbent using dynamic technique was also evaluated.
32521721	1	2	theme	materials	318:326	arg1	synthesis					288:296	the synthesis	284:296	the synthesis of novel functional materials	284:326	Materials coming from renewable resources have drawn recently an increased attention in various applications as an eco-friendly alternative in the synthesis of novel functional materials.
32521721	6	3	theme	dynamic	1259:1265	arg1	technique					1267:1275	dynamic technique	1259:1275	dynamic technique	1259:1275	Based on the optimized sorption conditions, the removal of the above-mentioned ions from aqueous solutions by the composite sorbent using dynamic technique was also evaluated.
32521721	1	4	theme	various	229:235	arg1	applications					237:248	various applications	229:248	various applications	229:248	Materials coming from renewable resources have drawn recently an increased attention in various applications as an eco-friendly alternative in the synthesis of novel functional materials.
32521721	0	5	theme	Cr3+	51:54	arg1	Ions					62:65	Cr3+ Metal Ions	51:65	Cr3+ Metal Ions	51:65	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.
32521721	2	6	theme	dilute	482:487	arg1	solutions					489:497	dilute solutions	482:497	dilute solutions	482:497	Polysaccharides, with their prominent representative - chitosan (CS), are well-known for their sorption properties, being able to remove metal ions from dilute solutions either by electrostatic interactions or chelation.
32521721	3	7	theme	industrial	664:673	arg1	wastewaters					675:685	industrial wastewaters	664:685	industrial wastewaters	664:685	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	1	8	from	alternative	269:279	arg1	synthesis					288:296	the synthesis	284:296	the synthesis of novel functional materials	284:326	Materials coming from renewable resources have drawn recently an increased attention in various applications as an eco-friendly alternative in the synthesis of novel functional materials.
32521721	5	9	dep	analysis	976:983	arg1	data					1025:1028	sorption data	1016:1028	sorption data	1016:1028	A deeper analysis of thermodynamics and kinetics sorption data was performed to get insights into the sorption mechanism of all metal ions onto sorbents.
32521721	0	10	theme	Metal	56:60	arg1	Ions					62:65	Cr3+ Metal Ions	51:65	Cr3+ Metal Ions	51:65	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.
32521721	5	11	theme	sorption	1069:1076	arg1	mechanism					1078:1086	the sorption mechanism	1065:1086	the sorption mechanism of all metal ions onto sorbents	1065:1118	A deeper analysis of thermodynamics and kinetics sorption data was performed to get insights into the sorption mechanism of all metal ions onto sorbents.
32521721	6	12	from	solutions	1218:1226	arg1	removal					1169:1175	the removal	1165:1175	the removal of the above-mentioned ions from aqueous solutions by the composite sorbent using dynamic technique	1165:1275	Based on the optimized sorption conditions, the removal of the above-mentioned ions from aqueous solutions by the composite sorbent using dynamic technique was also evaluated.
32521721	6	12	from	solutions	1218:1226	arg1	ions					1200:1203	the above-mentioned ions	1180:1203	the above-mentioned ions from aqueous solutions	1180:1226	Based on the optimized sorption conditions, the removal of the above-mentioned ions from aqueous solutions by the composite sorbent using dynamic technique was also evaluated.
32521721	0	13	theme	Comparative	2:12	arg1	Study					14:18	A Comparative Study	0:18	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.	0:139	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.
32521721	6	14	theme	ions	1200:1203	arg1	removal					1169:1175	the removal	1165:1175	the removal of the above-mentioned ions from aqueous solutions by the composite sorbent using dynamic technique	1165:1275	Based on the optimized sorption conditions, the removal of the above-mentioned ions from aqueous solutions by the composite sorbent using dynamic technique was also evaluated.
32521721	3	15	from	study	598:602	arg1	Ni2+					619:622	Ni2+	619:622	Ni2+	619:622	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	3	15	from	study	598:602	arg1	Zn2+					613:616	Zn2+	613:616	Zn2+	613:616	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	3	15	from	study	598:602	arg1	Cu2+					607:610	Cu2+	607:610	Cu2+	607:610	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	3	15	from	study	598:602	arg1	ions					646:649	Cr3+ metal ions	635:649	Cr3+ metal ions	635:649	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	3	15	from	study	598:602	arg1	Fe3+					625:628	Fe3+	625:628	Fe3+	625:628	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	3	16	theme	CS-based	690:697	arg1	cryogels					709:716	CS-based composite cryogels	690:716	CS-based composite cryogels using batch technique	690:738	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	6	17	theme	above-mentioned	1184:1198	arg1	ions					1200:1203	the above-mentioned ions	1180:1203	the above-mentioned ions from aqueous solutions	1180:1226	Based on the optimized sorption conditions, the removal of the above-mentioned ions from aqueous solutions by the composite sorbent using dynamic technique was also evaluated.
32521721	3	18	from	wastewaters	675:685	arg1	removal					651:657	removal	651:657	removal from industrial wastewaters by CS-based composite cryogels using batch technique	651:738	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	1	19	theme	eco-friendly	256:267	arg1	alternative					269:279	an eco-friendly alternative	253:279	an eco-friendly alternative in the synthesis of novel functional materials	253:326	Materials coming from renewable resources have drawn recently an increased attention in various applications as an eco-friendly alternative in the synthesis of novel functional materials.
32521721	1	19	theme	eco-friendly	256:267	arg1	attention					216:224	recently an increased attention	194:224	recently an increased attention in various applications	194:248	Materials coming from renewable resources have drawn recently an increased attention in various applications as an eco-friendly alternative in the synthesis of novel functional materials.
32521721	1	20	theme	renewable	163:171	arg1	resources					173:181	renewable resources	163:181	renewable resources	163:181	Materials coming from renewable resources have drawn recently an increased attention in various applications as an eco-friendly alternative in the synthesis of novel functional materials.
32521721	4	21	theme	sorption	877:884	arg1	performance					886:896	their sorption performance	871:896	their sorption performance	871:896	The composite cryogels consisting of CS embedding a natural zeolite, namely clinoptilolite, were synthesized by cryogelation, and their sorption performance were compared to those of CS cryogels and of acid-activated zeolite.
32521721	2	22	theme	electrostatic	509:521	arg1	interactions					523:534	electrostatic interactions	509:534	electrostatic interactions	509:534	Polysaccharides, with their prominent representative - chitosan (CS), are well-known for their sorption properties, being able to remove metal ions from dilute solutions either by electrostatic interactions or chelation.
32521721	6	23	theme	optimized	1134:1142	arg1	conditions					1153:1162	the optimized sorption conditions	1130:1162	the optimized sorption conditions	1130:1162	Based on the optimized sorption conditions, the removal of the above-mentioned ions from aqueous solutions by the composite sorbent using dynamic technique was also evaluated.
32521721	3	24	theme	batch	724:728	arg1	technique					730:738	batch technique	724:738	batch technique	724:738	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	0	25	theme	Industrial	80:89	arg1	Wastewaters					91:101	Industrial Wastewaters	80:101	Industrial Wastewaters	80:101	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.
32521721	2	26	with	Polysaccharides	329:343	arg1	chitosan					384:391	chitosan	384:391	chitosan (CS)	384:396	Polysaccharides, with their prominent representative - chitosan (CS), are well-known for their sorption properties, being able to remove metal ions from dilute solutions either by electrostatic interactions or chelation.
32521721	2	26	with	Polysaccharides	329:343	arg1	representative					367:380	their prominent representative	351:380	their prominent representative	351:380	Polysaccharides, with their prominent representative - chitosan (CS), are well-known for their sorption properties, being able to remove metal ions from dilute solutions either by electrostatic interactions or chelation.
32521721	2	26	with	Polysaccharides	329:343	arg1	CS					394:395	CS	394:395	CS	394:395	Polysaccharides, with their prominent representative - chitosan (CS), are well-known for their sorption properties, being able to remove metal ions from dilute solutions either by electrostatic interactions or chelation.
32521721	5	27	theme	deeper	969:974	arg1	analysis					976:983	A deeper analysis	967:983	A deeper analysis of thermodynamics	967:1001	A deeper analysis of thermodynamics and kinetics sorption data was performed to get insights into the sorption mechanism of all metal ions onto sorbents.
32521721	5	28	theme	ions	1101:1104	arg1	mechanism					1078:1086	the sorption mechanism	1065:1086	the sorption mechanism of all metal ions onto sorbents	1065:1118	A deeper analysis of thermodynamics and kinetics sorption data was performed to get insights into the sorption mechanism of all metal ions onto sorbents.
32521721	0	29	theme	Chitosan-Based	106:119	arg1	Cryogels					131:138	Chitosan-Based Composite Cryogels	106:138	Chitosan-Based Composite Cryogels	106:138	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.
32521721	3	30	theme	composite	699:707	arg1	cryogels					709:716	CS-based composite cryogels	690:716	CS-based composite cryogels using batch technique	690:738	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	2	31	dep	solutions	489:497	arg1	either					499:504	either	499:504	either	499:504	Polysaccharides, with their prominent representative - chitosan (CS), are well-known for their sorption properties, being able to remove metal ions from dilute solutions either by electrostatic interactions or chelation.
32521721	1	32	from	attention	216:224	arg1	applications					237:248	various applications	229:248	various applications	229:248	Materials coming from renewable resources have drawn recently an increased attention in various applications as an eco-friendly alternative in the synthesis of novel functional materials.
32521721	5	33	theme	thermodynamics	988:1001	arg1	kinetics					1007:1014	kinetics	1007:1014	kinetics	1007:1014	A deeper analysis of thermodynamics and kinetics sorption data was performed to get insights into the sorption mechanism of all metal ions onto sorbents.
32521721	5	33	theme	thermodynamics	988:1001	arg1	analysis					976:983	A deeper analysis	967:983	A deeper analysis of thermodynamics	967:1001	A deeper analysis of thermodynamics and kinetics sorption data was performed to get insights into the sorption mechanism of all metal ions onto sorbents.
32521721	0	34	dep	Cu2+	23:26	arg1	Removal					67:73	Removal	67:73	Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels	67:138	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.
32521721	5	35	theme	metal	1095:1099	arg1	ions					1101:1104	all metal ions	1091:1104	all metal ions onto sorbents	1091:1118	A deeper analysis of thermodynamics and kinetics sorption data was performed to get insights into the sorption mechanism of all metal ions onto sorbents.
32521721	3	36	theme	Cr3+	635:638	arg1	ions					646:649	Cr3+ metal ions	635:649	Cr3+ metal ions	635:649	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	6	37	from	removal	1169:1175	arg1	solutions					1218:1226	aqueous solutions	1210:1226	aqueous solutions	1210:1226	Based on the optimized sorption conditions, the removal of the above-mentioned ions from aqueous solutions by the composite sorbent using dynamic technique was also evaluated.
32521721	1	38	theme	novel	301:305	arg1	materials					318:326	novel functional materials	301:326	novel functional materials	301:326	Materials coming from renewable resources have drawn recently an increased attention in various applications as an eco-friendly alternative in the synthesis of novel functional materials.
32521721	3	39	theme	comparative	586:596	arg1	study					598:602	a comparative study	584:602	a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique	584:738	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	0	40	from	Wastewaters	91:101	arg1	Removal					67:73	Removal	67:73	Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels	67:138	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.
32521721	0	41	theme	Composite	121:129	arg1	Cryogels					131:138	Chitosan-Based Composite Cryogels	106:138	Chitosan-Based Composite Cryogels	106:138	A Comparative Study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ Metal Ions Removal from Industrial Wastewaters by Chitosan-Based Composite Cryogels.
32521721	6	42	theme	aqueous	1210:1216	arg1	solutions					1218:1226	aqueous solutions	1210:1226	aqueous solutions	1210:1226	Based on the optimized sorption conditions, the removal of the above-mentioned ions from aqueous solutions by the composite sorbent using dynamic technique was also evaluated.
32521721	3	43	dep	Cu2+	607:610	arg1	removal					651:657	removal	651:657	removal from industrial wastewaters by CS-based composite cryogels using batch technique	651:738	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	4	44	theme	CS	924:925	arg1	cryogels					927:934	CS cryogels	924:934	CS cryogels	924:934	The composite cryogels consisting of CS embedding a natural zeolite, namely clinoptilolite, were synthesized by cryogelation, and their sorption performance were compared to those of CS cryogels and of acid-activated zeolite.
32521721	5	45	theme	sorption	1016:1023	arg1	data					1025:1028	sorption data	1016:1028	sorption data	1016:1028	A deeper analysis of thermodynamics and kinetics sorption data was performed to get insights into the sorption mechanism of all metal ions onto sorbents.
32521721	6	46	theme	sorption	1144:1151	arg1	conditions					1153:1162	the optimized sorption conditions	1130:1162	the optimized sorption conditions	1130:1162	Based on the optimized sorption conditions, the removal of the above-mentioned ions from aqueous solutions by the composite sorbent using dynamic technique was also evaluated.
32521721	2	47	theme	prominent	357:365	arg1	representative					367:380	their prominent representative	351:380	their prominent representative	351:380	Polysaccharides, with their prominent representative - chitosan (CS), are well-known for their sorption properties, being able to remove metal ions from dilute solutions either by electrostatic interactions or chelation.
32521721	1	48	theme	increased	206:214	arg1	alternative					269:279	an eco-friendly alternative	253:279	an eco-friendly alternative in the synthesis of novel functional materials	253:326	Materials coming from renewable resources have drawn recently an increased attention in various applications as an eco-friendly alternative in the synthesis of novel functional materials.
32521721	1	48	theme	increased	206:214	arg1	attention					216:224	recently an increased attention	194:224	recently an increased attention in various applications	194:248	Materials coming from renewable resources have drawn recently an increased attention in various applications as an eco-friendly alternative in the synthesis of novel functional materials.
32521721	2	49	theme	metal	466:470	arg1	ions					472:475	metal ions	466:475	metal ions	466:475	Polysaccharides, with their prominent representative - chitosan (CS), are well-known for their sorption properties, being able to remove metal ions from dilute solutions either by electrostatic interactions or chelation.
32521721	1	50	theme	functional	307:316	arg1	materials					318:326	novel functional materials	301:326	novel functional materials	301:326	Materials coming from renewable resources have drawn recently an increased attention in various applications as an eco-friendly alternative in the synthesis of novel functional materials.
32521721	4	51	theme	composite	745:753	arg1	cryogels					755:762	The composite cryogels	741:762	The composite cryogels consisting of CS embedding a natural zeolite, namely clinoptilolite,	741:831	The composite cryogels consisting of CS embedding a natural zeolite, namely clinoptilolite, were synthesized by cryogelation, and their sorption performance were compared to those of CS cryogels and of acid-activated zeolite.
32521721	3	52	theme	metal	640:644	arg1	ions					646:649	Cr3+ metal ions	635:649	Cr3+ metal ions	635:649	In this context, we proposed here a comparative study on Cu2+, Zn2+, Ni2+, Fe3+, and Cr3+ metal ions removal from industrial wastewaters by CS-based composite cryogels using batch technique.
32521721	2	53	theme	sorption	424:431	arg1	properties					433:442	their sorption properties	418:442	their sorption properties	418:442	Polysaccharides, with their prominent representative - chitosan (CS), are well-known for their sorption properties, being able to remove metal ions from dilute solutions either by electrostatic interactions or chelation.
34662653	0	0	theme	sustained	98:106	arg1	release					108:114	sustained release	98:114	sustained release of curcumin	98:126	Fabrication and characterization of bamboo shoot cellulose/sodium alginate composite aerogels for sustained release of curcumin.
34662653	1	1	theme	shoot	172:176	arg1	BSC					189:191	unmodified bamboo shoot cellulose (BSC)	154:192	unmodified bamboo shoot cellulose (BSC)	154:192	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	5	2	from	cross-linking	1027:1039	arg1	matrix					1060:1065	the SA matrix	1053:1065	the SA matrix	1053:1065	Interpenetrating network structures were built between BSC and SA mainly through hydrogen bonding, which could be further reinforced by the cross-linking of CaCO3 on the SA matrix.
34662653	7	3	theme	mechanical	1176:1185	arg1	properties					1187:1196	mechanical properties	1176:1196	mechanical properties	1176:1196	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	3	4	theme	encapsulated	705:716	arg1	curcumin					718:725	encapsulated curcumin	705:725	encapsulated curcumin	705:725	The encapsulation and release of curcumin from aerogels were studied while the antioxidant activity of encapsulated curcumin was investigated.
34662653	1	5	theme	cellulose	178:186	arg1	BSC					189:191	unmodified bamboo shoot cellulose (BSC)	154:192	unmodified bamboo shoot cellulose (BSC)	154:192	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	2	6	dep	transform	531:539	arg1	infrared					541:548	infrared	541:548	transform infrared spectroscopy and differential scanning calorimetry	531:599	The aerogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry.
34662653	3	7	theme	curcumin	718:725	arg1	activity					693:700	the antioxidant activity	677:700	the antioxidant activity of encapsulated curcumin	677:725	The encapsulation and release of curcumin from aerogels were studied while the antioxidant activity of encapsulated curcumin was investigated.
34662653	1	8	theme	structural	416:425	arg1	stability					427:435	the structural stability	412:435	the structural stability of aerogel skeleton	412:455	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	5	9	theme	CaCO3	1044:1048	arg1	cross-linking					1027:1039	the cross-linking	1023:1039	the cross-linking of CaCO3 on the SA matrix	1023:1065	Interpenetrating network structures were built between BSC and SA mainly through hydrogen bonding, which could be further reinforced by the cross-linking of CaCO3 on the SA matrix.
34662653	2	10	dep	Fourier	523:529	arg1	transform					531:539	transform	531:539	transform infrared spectroscopy and differential scanning calorimetry	531:599	The aerogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry.
34662653	1	11	theme	first	329:333	arg1	time					335:338	the first time	325:338	the first time	325:338	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	7	12	theme	thermal	1154:1160	arg1	stability					1162:1170	thermal stability	1154:1170	thermal stability	1154:1170	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	7	13	theme	uncross-linked	1279:1292	arg1	aerogels					1304:1311	the uncross-linked composite aerogels	1275:1311	the uncross-linked composite aerogels	1275:1311	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	1	14	theme	fast	255:258	arg1	way					270:272	a fast and green way	253:272	a fast and green way for sustained release of curcumin	253:306	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	2	15	theme	electron	502:509	arg1	Fourier					523:529	Fourier	523:529	Fourier transform infrared spectroscopy and differential scanning calorimetry	523:599	The aerogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry.
34662653	2	15	theme	electron	502:509	arg1	microscopy					511:520	scanning electron microscopy	493:520	scanning electron microscopy	493:520	The aerogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry.
34662653	7	16	theme	better	1323:1328	arg1	efficiency					1344:1353	better encapsulation efficiency	1323:1353	better encapsulation efficiency	1323:1353	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	7	17	dep	in	1359:1360	arg1	vitro					1362:1366	vitro	1362:1366	vitro	1362:1366	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	7	18	dep	stability	1162:1170	arg1	The					1150:1152	The	1150:1152	The	1150:1152	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	0	19	theme	curcumin	119:126	arg1	release					108:114	sustained release	98:114	sustained release of curcumin	98:126	Fabrication and characterization of bamboo shoot cellulose/sodium alginate composite aerogels for sustained release of curcumin.
34662653	1	20	theme	aerogel	440:446	arg1	skeleton					448:455	aerogel skeleton	440:455	aerogel skeleton	440:455	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	6	21	theme	composite	1111:1119	arg1	aerogels					1121:1128	the composite aerogels	1107:1128	the composite aerogels	1107:1128	The original characteristics of BSC in the composite aerogels were well retained.
34662653	8	22	theme	drug	1483:1486	arg1	purposes					1497:1504	drug delivery purposes	1483:1504	drug delivery purposes	1483:1504	Overall, this study was the first to use cellulose from bamboo shoot to develop aerogels for drug delivery purposes.
34662653	7	23	theme	antioxidant	1368:1378	arg1	activity					1380:1387	in vitro antioxidant activity	1359:1387	in vitro antioxidant activity	1359:1387	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	1	24	theme	skeleton	448:455	arg1	stability					427:435	the structural stability	412:435	the structural stability of aerogel skeleton	412:455	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	3	25	dep	encapsulation	606:618	arg1	The					602:604	The	602:604	The	602:604	The encapsulation and release of curcumin from aerogels were studied while the antioxidant activity of encapsulated curcumin was investigated.
34662653	9	26	theme	cellulose/alginate	1511:1528	arg1	carriers					1592:1599	biocompatible carriers	1578:1599	biocompatible carriers for drug and nutraceutical delivery	1578:1635	The cellulose/alginate composite aerogels were promising to be used as biocompatible carriers for drug and nutraceutical delivery.
34662653	9	26	theme	cellulose/alginate	1511:1528	arg1	promising					1554:1562	promising	1554:1562	promising	1554:1562	The cellulose/alginate composite aerogels were promising to be used as biocompatible carriers for drug and nutraceutical delivery.
34662653	9	26	theme	cellulose/alginate	1511:1528	arg1	aerogels					1540:1547	The cellulose/alginate composite aerogels	1507:1547	The cellulose/alginate composite aerogels	1507:1547	The cellulose/alginate composite aerogels were promising to be used as biocompatible carriers for drug and nutraceutical delivery.
34662653	7	27	theme	composite	1205:1213	arg1	aerogels					1215:1222	the composite aerogels	1201:1222	the composite aerogels	1201:1222	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	1	28	theme	green	264:268	arg1	way					270:272	a fast and green way	253:272	a fast and green way for sustained release of curcumin	253:306	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	1	29	with	aerogels	215:222	arg1	SA					246:247	SA	246:247	SA	246:247	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	1	29	with	aerogels	215:222	arg1	alginate					236:243	sodium alginate	229:243	sodium alginate (SA)	229:248	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	4	30	theme	composite	785:793	arg1	aerogels					795:802	the composite aerogels	781:802	the composite aerogels	781:802	Curcumin was evenly encapsulated in the composite aerogels and showed a sustained release behavior, followed the first-order rate expression.
34662653	6	31	theme	BSC	1100:1102	arg1	characteristics					1081:1095	The original characteristics	1068:1095	The original characteristics of BSC in the composite aerogels	1068:1128	The original characteristics of BSC in the composite aerogels were well retained.
34662653	7	32	theme	aerogels	1215:1222	arg1	stability					1162:1170	thermal stability	1154:1170	thermal stability	1154:1170	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	7	32	theme	aerogels	1215:1222	arg1	properties					1187:1196	mechanical properties	1176:1196	mechanical properties	1176:1196	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	8	33	theme	bamboo	1446:1451	arg1	shoot					1453:1457	bamboo shoot	1446:1457	bamboo shoot	1446:1457	Overall, this study was the first to use cellulose from bamboo shoot to develop aerogels for drug delivery purposes.
34662653	9	34	theme	nutraceutical	1614:1626	arg1	delivery					1628:1635	nutraceutical delivery	1614:1635	nutraceutical delivery	1614:1635	The cellulose/alginate composite aerogels were promising to be used as biocompatible carriers for drug and nutraceutical delivery.
34662653	1	35	theme	composite	205:213	arg1	aerogels					215:222	composite aerogels	205:222	composite aerogels with sodium alginate (SA)	205:248	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	0	36	theme	shoot	43:47	arg1	aerogels					85:92	bamboo shoot cellulose/sodium alginate composite aerogels	36:92	bamboo shoot cellulose/sodium alginate composite aerogels	36:92	Fabrication and characterization of bamboo shoot cellulose/sodium alginate composite aerogels for sustained release of curcumin.
34662653	1	37	theme	calcium	350:356	arg1	cross-linking					373:385	calcium ion-induced SA cross-linking	350:385	calcium ion-induced SA cross-linking	350:385	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	5	38	theme	SA	1057:1058	arg1	matrix					1060:1065	the SA matrix	1053:1065	the SA matrix	1053:1065	Interpenetrating network structures were built between BSC and SA mainly through hydrogen bonding, which could be further reinforced by the cross-linking of CaCO3 on the SA matrix.
34662653	6	39	from	characteristics	1081:1095	arg1	aerogels					1121:1128	the composite aerogels	1107:1128	the composite aerogels	1107:1128	The original characteristics of BSC in the composite aerogels were well retained.
34662653	5	40	theme	Interpenetrating	887:902	arg1	structures					912:921	Interpenetrating network structures	887:921	Interpenetrating network structures	887:921	Interpenetrating network structures were built between BSC and SA mainly through hydrogen bonding, which could be further reinforced by the cross-linking of CaCO3 on the SA matrix.
34662653	0	41	theme	bamboo	36:41	arg1	aerogels					85:92	bamboo shoot cellulose/sodium alginate composite aerogels	36:92	bamboo shoot cellulose/sodium alginate composite aerogels	36:92	Fabrication and characterization of bamboo shoot cellulose/sodium alginate composite aerogels for sustained release of curcumin.
34662653	1	42	theme	sustained	278:286	arg1	release					288:294	sustained release	278:294	sustained release of curcumin	278:306	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	1	43	theme	ion-induced	358:368	arg1	cross-linking					373:385	calcium ion-induced SA cross-linking	350:385	calcium ion-induced SA cross-linking	350:385	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	7	44	theme	Ca2+-induced	1241:1252	arg1	cross-linking					1254:1266	Ca2+-induced cross-linking	1241:1266	Ca2+-induced cross-linking	1241:1266	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	5	45	theme	network	904:910	arg1	structures					912:921	Interpenetrating network structures	887:921	Interpenetrating network structures	887:921	Interpenetrating network structures were built between BSC and SA mainly through hydrogen bonding, which could be further reinforced by the cross-linking of CaCO3 on the SA matrix.
34662653	2	46	theme	scanning	493:500	arg1	Fourier					523:529	Fourier	523:529	Fourier transform infrared spectroscopy and differential scanning calorimetry	523:599	The aerogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry.
34662653	2	46	theme	scanning	493:500	arg1	microscopy					511:520	scanning electron microscopy	493:520	scanning electron microscopy	493:520	The aerogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry.
34662653	0	47	theme	alginate	66:73	arg1	aerogels					85:92	bamboo shoot cellulose/sodium alginate composite aerogels	36:92	bamboo shoot cellulose/sodium alginate composite aerogels	36:92	Fabrication and characterization of bamboo shoot cellulose/sodium alginate composite aerogels for sustained release of curcumin.
34662653	3	48	from	aerogels	649:656	arg1	encapsulation					606:618	encapsulation	606:618	encapsulation	606:618	The encapsulation and release of curcumin from aerogels were studied while the antioxidant activity of encapsulated curcumin was investigated.
34662653	3	48	from	aerogels	649:656	arg1	release					624:630	release	624:630	release	624:630	The encapsulation and release of curcumin from aerogels were studied while the antioxidant activity of encapsulated curcumin was investigated.
34662653	6	49	theme	original	1072:1079	arg1	characteristics					1081:1095	The original characteristics	1068:1095	The original characteristics of BSC in the composite aerogels	1068:1128	The original characteristics of BSC in the composite aerogels were well retained.
34662653	1	50	theme	SA	370:371	arg1	cross-linking					373:385	calcium ion-induced SA cross-linking	350:385	calcium ion-induced SA cross-linking	350:385	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	4	51	theme	rate	870:873	arg1	expression					875:884	the first-order rate expression	854:884	the first-order rate expression	854:884	Curcumin was evenly encapsulated in the composite aerogels and showed a sustained release behavior, followed the first-order rate expression.
34662653	7	52	theme	in	1359:1360	arg1	activity					1380:1387	in vitro antioxidant activity	1359:1387	in vitro antioxidant activity	1359:1387	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	0	53	theme	cellulose/sodium	49:64	arg1	aerogels					85:92	bamboo shoot cellulose/sodium alginate composite aerogels	36:92	bamboo shoot cellulose/sodium alginate composite aerogels	36:92	Fabrication and characterization of bamboo shoot cellulose/sodium alginate composite aerogels for sustained release of curcumin.
34662653	2	54	theme	scanning	580:587	arg1	calorimetry					589:599	differential scanning calorimetry	567:599	differential scanning calorimetry	567:599	The aerogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry.
34662653	4	55	theme	first-order	858:868	arg1	rate					870:873	the first-order rate	854:873	the first-order rate expression	854:884	Curcumin was evenly encapsulated in the composite aerogels and showed a sustained release behavior, followed the first-order rate expression.
34662653	5	56	theme	hydrogen	968:975	arg1	bonding					977:983	hydrogen bonding	968:983	hydrogen bonding	968:983	Interpenetrating network structures were built between BSC and SA mainly through hydrogen bonding, which could be further reinforced by the cross-linking of CaCO3 on the SA matrix.
34662653	8	57	theme	delivery	1488:1495	arg1	purposes					1497:1504	drug delivery purposes	1483:1504	drug delivery purposes	1483:1504	Overall, this study was the first to use cellulose from bamboo shoot to develop aerogels for drug delivery purposes.
34662653	1	58	theme	curcumin	299:306	arg1	release					288:294	sustained release	278:294	sustained release of curcumin	278:306	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	2	59	theme	differential	567:578	arg1	calorimetry					589:599	differential scanning calorimetry	567:599	differential scanning calorimetry	567:599	The aerogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry.
34662653	4	60	theme	release	827:833	arg1	behavior					835:842	a sustained release behavior	815:842	a sustained release behavior	815:842	Curcumin was evenly encapsulated in the composite aerogels and showed a sustained release behavior, followed the first-order rate expression.
34662653	3	61	theme	curcumin	635:642	arg1	encapsulation					606:618	encapsulation	606:618	encapsulation	606:618	The encapsulation and release of curcumin from aerogels were studied while the antioxidant activity of encapsulated curcumin was investigated.
34662653	3	61	theme	curcumin	635:642	arg1	release					624:630	release	624:630	release	624:630	The encapsulation and release of curcumin from aerogels were studied while the antioxidant activity of encapsulated curcumin was investigated.
34662653	9	62	theme	biocompatible	1578:1590	arg1	aerogels					1540:1547	The cellulose/alginate composite aerogels	1507:1547	The cellulose/alginate composite aerogels	1507:1547	The cellulose/alginate composite aerogels were promising to be used as biocompatible carriers for drug and nutraceutical delivery.
34662653	9	62	theme	biocompatible	1578:1590	arg1	carriers					1592:1599	biocompatible carriers	1578:1599	biocompatible carriers for drug and nutraceutical delivery	1578:1635	The cellulose/alginate composite aerogels were promising to be used as biocompatible carriers for drug and nutraceutical delivery.
34662653	7	63	link	uncross-linked	1279:1292	arg1	aerogels					1304:1311	the uncross-linked composite aerogels	1275:1311	the uncross-linked composite aerogels	1275:1311	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	1	64	theme	sodium	229:234	arg1	SA					246:247	SA	246:247	SA	246:247	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	1	64	theme	sodium	229:234	arg1	alginate					236:243	sodium alginate	229:243	sodium alginate (SA)	229:248	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	4	65	theme	sustained	817:825	arg1	behavior					835:842	a sustained release behavior	815:842	a sustained release behavior	815:842	Curcumin was evenly encapsulated in the composite aerogels and showed a sustained release behavior, followed the first-order rate expression.
34662653	7	66	theme	encapsulation	1330:1342	arg1	efficiency					1344:1353	better encapsulation efficiency	1323:1353	better encapsulation efficiency	1323:1353	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	0	67	theme	aerogels	85:92	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Fabrication and characterization of bamboo shoot cellulose/sodium alginate composite aerogels for sustained release of curcumin.
34662653	0	67	theme	aerogels	85:92	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and characterization of bamboo shoot cellulose/sodium alginate composite aerogels for sustained release of curcumin.
34662653	3	68	theme	antioxidant	681:691	arg1	activity					693:700	the antioxidant activity	677:700	the antioxidant activity of encapsulated curcumin	677:725	The encapsulation and release of curcumin from aerogels were studied while the antioxidant activity of encapsulated curcumin was investigated.
34662653	1	69	theme	unmodified	154:163	arg1	BSC					189:191	unmodified bamboo shoot cellulose (BSC)	154:192	unmodified bamboo shoot cellulose (BSC)	154:192	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	7	70	theme	composite	1294:1302	arg1	aerogels					1304:1311	the uncross-linked composite aerogels	1275:1311	the uncross-linked composite aerogels	1275:1311	The thermal stability and mechanical properties of the composite aerogels were improved by Ca2+-induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity.
34662653	0	71	theme	composite	75:83	arg1	aerogels					85:92	bamboo shoot cellulose/sodium alginate composite aerogels	36:92	bamboo shoot cellulose/sodium alginate composite aerogels	36:92	Fabrication and characterization of bamboo shoot cellulose/sodium alginate composite aerogels for sustained release of curcumin.
34662653	9	72	theme	composite	1530:1538	arg1	carriers					1592:1599	biocompatible carriers	1578:1599	biocompatible carriers for drug and nutraceutical delivery	1578:1635	The cellulose/alginate composite aerogels were promising to be used as biocompatible carriers for drug and nutraceutical delivery.
34662653	9	72	theme	composite	1530:1538	arg1	promising					1554:1562	promising	1554:1562	promising	1554:1562	The cellulose/alginate composite aerogels were promising to be used as biocompatible carriers for drug and nutraceutical delivery.
34662653	9	72	theme	composite	1530:1538	arg1	aerogels					1540:1547	The cellulose/alginate composite aerogels	1507:1547	The cellulose/alginate composite aerogels	1507:1547	The cellulose/alginate composite aerogels were promising to be used as biocompatible carriers for drug and nutraceutical delivery.
34662653	9	73	used	used	1570:1573	arg2	carriers					1592:1599	biocompatible carriers	1578:1599	biocompatible carriers for drug and nutraceutical delivery	1578:1635	The cellulose/alginate composite aerogels were promising to be used as biocompatible carriers for drug and nutraceutical delivery.
34662653	9	73	used	used	1570:1573	arg2	promising					1554:1562	promising	1554:1562	promising	1554:1562	The cellulose/alginate composite aerogels were promising to be used as biocompatible carriers for drug and nutraceutical delivery.
34662653	9	73	used	used	1570:1573	arg2	aerogels					1540:1547	The cellulose/alginate composite aerogels	1507:1547	The cellulose/alginate composite aerogels	1507:1547	The cellulose/alginate composite aerogels were promising to be used as biocompatible carriers for drug and nutraceutical delivery.
34662653	1	74	theme	bamboo	165:170	arg1	BSC					189:191	unmodified bamboo shoot cellulose (BSC)	154:192	unmodified bamboo shoot cellulose (BSC)	154:192	The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton.
34662653	8	75	from	shoot	1453:1457	arg1	cellulose					1431:1439	cellulose	1431:1439	cellulose from bamboo shoot	1431:1457	Overall, this study was the first to use cellulose from bamboo shoot to develop aerogels for drug delivery purposes.
32574733	1	0	theme	environmental	157:169	arg1	problems					171:178	the environmental problems	153:178	the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads	153:445	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	4	1	theme	outstanding	757:767	arg1	selectivity					779:789	the outstanding phosphate selectivity	753:789	the outstanding phosphate selectivity of SA-La@PEI	753:802	More importantly, the outstanding phosphate selectivity of SA-La@PEI was exposed when NO3-, HCO3-, SO42- and Cl- were added to the phosphate solution.
32574733	1	2	theme	efficient	261:269	arg1	bio-sorbent					271:281	highly efficient bio-sorbent	254:281	highly efficient bio-sorbent (SA-La@PEI)	254:293	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	1	2	theme	efficient	261:269	arg1	PEI					290:292	SA-La@PEI	284:292	SA-La@PEI	284:292	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	0	3	theme	affinity	80:87	arg1	component					89:97	sorption affinity component	71:97	sorption affinity component for enhanced phosphate capture	71:128	Network interior and surface engineering of alginate-based beads using sorption affinity component for enhanced phosphate capture.
32574733	3	4	theme	121.2 mg/g	675:684	arg1	performance					660:670	excellent adsorption performance	639:670	excellent adsorption performance of 121.2 mg/g, which was better than most published materials	639:732	Through detailed tests, SA-La@PEI exhibited excellent adsorption performance of 121.2 mg/g, which was better than most published materials.
32574733	2	5	theme	PEI	590:592	arg1	morphology					537:546	morphology	537:546	morphology	537:546	Various characterization methods like SEM, FTIR, XRD and XPS were adopted to examine the morphology and functional group composition of SA-La@PEI.
32574733	2	5	theme	PEI	590:592	arg1	composition					569:579	functional group composition	552:579	functional group composition	552:579	Various characterization methods like SEM, FTIR, XRD and XPS were adopted to examine the morphology and functional group composition of SA-La@PEI.
32574733	1	6	theme	beads	441:445	arg1	engineering					417:427	sorption affinity component mediated and poly(ethylenimine) surface engineering	349:427	sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads	349:445	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	5	7	theme	phosphate	1044:1052	arg1	adsorption					1054:1063	phosphate adsorption	1044:1063	phosphate adsorption	1044:1063	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	1	8	theme	bio-sorbent	271:281	arg1	discharge					200:208	excessive discharge	190:208	excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate	190:307	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	0	9	theme	enhanced	103:110	arg1	capture					122:128	enhanced phosphate capture	103:128	enhanced phosphate capture	103:128	Network interior and surface engineering of alginate-based beads using sorption affinity component for enhanced phosphate capture.
32574733	1	10	theme	sorption	349:356	arg1	component					367:375	sorption affinity component	349:375	sorption affinity component	349:375	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	2	11	theme	@	589:589	arg1	PEI					590:592	SA-La@PEI	584:592	SA-La@PEI	584:592	Various characterization methods like SEM, FTIR, XRD and XPS were adopted to examine the morphology and functional group composition of SA-La@PEI.
32574733	6	12	theme	phosphate	1169:1177	arg1	decontamination					1140:1154	the decontamination	1136:1154	the decontamination of excessive phosphate	1136:1177	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	1	13	dep	surface	409:415	arg1	ethylenimine					395:406	ethylenimine	395:406	ethylenimine	395:406	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	1	13	dep	surface	409:415	arg1	poly					390:393	poly	390:393	poly	390:393	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	1	14	theme	affinity	358:365	arg1	component					367:375	sorption affinity component	349:375	sorption affinity component	349:375	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	2	15	theme	SA-La	584:588	arg1	PEI					590:592	SA-La@PEI	584:592	SA-La@PEI	584:592	Various characterization methods like SEM, FTIR, XRD and XPS were adopted to examine the morphology and functional group composition of SA-La@PEI.
32574733	6	16	theme	SA-La	1087:1091	arg1	sorbent					1124:1130	a promising sorbent	1112:1130	a promising sorbent for the decontamination of excessive phosphate	1112:1177	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	6	16	theme	SA-La	1087:1091	arg1	beads					1097:1101	as-prepared SA-La@PEI beads	1075:1101	as-prepared SA-La@PEI beads	1075:1101	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	1	17	theme	SA-La	284:288	arg1	bio-sorbent					271:281	highly efficient bio-sorbent	254:281	highly efficient bio-sorbent (SA-La@PEI)	254:293	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	1	17	theme	SA-La	284:288	arg1	PEI					290:292	SA-La@PEI	284:292	SA-La@PEI	284:292	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	3	18	theme	published	714:722	arg1	materials					724:732	most published materials	709:732	most published materials	709:732	Through detailed tests, SA-La@PEI exhibited excellent adsorption performance of 121.2 mg/g, which was better than most published materials.
32574733	4	19	theme	phosphate	769:777	arg1	selectivity					779:789	the outstanding phosphate selectivity	753:789	the outstanding phosphate selectivity of SA-La@PEI	753:802	More importantly, the outstanding phosphate selectivity of SA-La@PEI was exposed when NO3-, HCO3-, SO42- and Cl- were added to the phosphate solution.
32574733	0	20	theme	phosphate	112:120	arg1	capture					122:128	enhanced phosphate capture	103:128	enhanced phosphate capture	103:128	Network interior and surface engineering of alginate-based beads using sorption affinity component for enhanced phosphate capture.
32574733	1	21	theme	mediated	377:384	arg1	engineering					417:427	sorption affinity component mediated and poly(ethylenimine) surface engineering	349:427	sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads	349:445	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	2	22	theme	Various	448:454	arg1	methods					473:479	Various characterization methods	448:479	Various characterization methods like SEM, FTIR, XRD and XPS	448:507	Various characterization methods like SEM, FTIR, XRD and XPS were adopted to examine the morphology and functional group composition of SA-La@PEI.
32574733	6	23	theme	as-prepared	1075:1085	arg1	sorbent					1124:1130	a promising sorbent	1112:1130	a promising sorbent for the decontamination of excessive phosphate	1112:1177	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	6	23	theme	as-prepared	1075:1085	arg1	beads					1097:1101	as-prepared SA-La@PEI beads	1075:1101	as-prepared SA-La@PEI beads	1075:1101	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	2	24	theme	characterization	456:471	arg1	methods					473:479	Various characterization methods	448:479	Various characterization methods like SEM, FTIR, XRD and XPS	448:507	Various characterization methods like SEM, FTIR, XRD and XPS were adopted to examine the morphology and functional group composition of SA-La@PEI.
32574733	6	25	theme	mechanical	1241:1250	arg1	strength					1252:1259	mechanical strength	1241:1259	mechanical strength	1241:1259	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	5	26	theme	integrated	902:911	arg1	components					913:922	the integrated components	898:922	the integrated components in composites	898:936	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	1	27	theme	excessive	190:198	arg1	discharge					200:208	excessive discharge	190:208	excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate	190:307	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	0	28	theme	Network	0:6	arg1	interior					8:15	Network interior	0:15	Network interior	0:15	Network interior and surface engineering of alginate-based beads using sorption affinity component for enhanced phosphate capture.
32574733	1	29	theme	@	289:289	arg1	bio-sorbent					271:281	highly efficient bio-sorbent	254:281	highly efficient bio-sorbent (SA-La@PEI)	254:293	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	1	29	theme	@	289:289	arg1	PEI					290:292	SA-La@PEI	284:292	SA-La@PEI	284:292	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	3	30	theme	adsorption	649:658	arg1	performance					660:670	excellent adsorption performance	639:670	excellent adsorption performance of 121.2 mg/g, which was better than most published materials	639:732	Through detailed tests, SA-La@PEI exhibited excellent adsorption performance of 121.2 mg/g, which was better than most published materials.
32574733	5	31	theme	dominant	1021:1028	arg1	attraction					985:994	electrostatic attraction	971:994	electrostatic attraction	971:994	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	5	31	theme	dominant	1021:1028	arg1	mechanisms					1030:1039	the dominant mechanisms	1017:1039	the dominant mechanisms of phosphate adsorption	1017:1063	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	5	31	theme	dominant	1021:1028	arg1	precipitation					953:965	chemical precipitation	944:965	chemical precipitation	944:965	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	0	32	theme	surface	21:27	arg1	engineering					29:39	surface engineering	21:39	surface engineering	21:39	Network interior and surface engineering of alginate-based beads using sorption affinity component for enhanced phosphate capture.
32574733	5	33	theme	chemical	944:951	arg1	attraction					985:994	electrostatic attraction	971:994	electrostatic attraction	971:994	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	5	33	theme	chemical	944:951	arg1	mechanisms					1030:1039	the dominant mechanisms	1017:1039	the dominant mechanisms of phosphate adsorption	1017:1063	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	5	33	theme	chemical	944:951	arg1	precipitation					953:965	chemical precipitation	944:965	chemical precipitation	944:965	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	5	34	theme	adsorption	1054:1063	arg1	attraction					985:994	electrostatic attraction	971:994	electrostatic attraction	971:994	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	5	34	theme	adsorption	1054:1063	arg1	mechanisms					1030:1039	the dominant mechanisms	1017:1039	the dominant mechanisms of phosphate adsorption	1017:1063	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	5	34	theme	adsorption	1054:1063	arg1	precipitation					953:965	chemical precipitation	944:965	chemical precipitation	944:965	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	6	35	theme	promising	1114:1122	arg1	sorbent					1124:1130	a promising sorbent	1112:1130	a promising sorbent for the decontamination of excessive phosphate	1112:1177	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	6	35	theme	promising	1114:1122	arg1	beads					1097:1101	as-prepared SA-La@PEI beads	1075:1101	as-prepared SA-La@PEI beads	1075:1101	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	1	36	theme	phosphate	213:221	arg1	discharge					200:208	excessive discharge	190:208	excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate	190:307	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	3	37	theme	SA-La	619:623	arg1	PEI					625:627	SA-La@PEI	619:627	SA-La@PEI	619:627	Through detailed tests, SA-La@PEI exhibited excellent adsorption performance of 121.2 mg/g, which was better than most published materials.
32574733	4	38	theme	PEI	800:802	arg1	selectivity					779:789	the outstanding phosphate selectivity	753:789	the outstanding phosphate selectivity of SA-La@PEI	753:802	More importantly, the outstanding phosphate selectivity of SA-La@PEI was exposed when NO3-, HCO3-, SO42- and Cl- were added to the phosphate solution.
32574733	2	39	dep	morphology	537:546	arg1	the					533:535	the	533:535	the	533:535	Various characterization methods like SEM, FTIR, XRD and XPS were adopted to examine the morphology and functional group composition of SA-La@PEI.
32574733	0	40	theme	beads	59:63	arg1	interior					8:15	Network interior	0:15	Network interior	0:15	Network interior and surface engineering of alginate-based beads using sorption affinity component for enhanced phosphate capture.
32574733	0	40	theme	beads	59:63	arg1	engineering					29:39	surface engineering	21:39	surface engineering	21:39	Network interior and surface engineering of alginate-based beads using sorption affinity component for enhanced phosphate capture.
32574733	3	41	theme	@	624:624	arg1	PEI					625:627	SA-La@PEI	619:627	SA-La@PEI	619:627	Through detailed tests, SA-La@PEI exhibited excellent adsorption performance of 121.2 mg/g, which was better than most published materials.
32574733	4	42	theme	phosphate	866:874	arg1	solution					876:883	the phosphate solution	862:883	the phosphate solution	862:883	More importantly, the outstanding phosphate selectivity of SA-La@PEI was exposed when NO3-, HCO3-, SO42- and Cl- were added to the phosphate solution.
32574733	0	43	theme	alginate-based	44:57	arg1	beads					59:63	alginate-based beads	44:63	alginate-based beads using sorption affinity component for enhanced phosphate capture	44:128	Network interior and surface engineering of alginate-based beads using sorption affinity component for enhanced phosphate capture.
32574733	6	44	theme	excessive	1159:1167	arg1	phosphate					1169:1177	excessive phosphate	1159:1177	excessive phosphate	1159:1177	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	1	45	theme	surface	409:415	arg1	engineering					417:427	sorption affinity component mediated and poly(ethylenimine) surface engineering	349:427	sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads	349:445	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	4	46	theme	SA-La	794:798	arg1	PEI					800:802	SA-La@PEI	794:802	SA-La@PEI	794:802	More importantly, the outstanding phosphate selectivity of SA-La@PEI was exposed when NO3-, HCO3-, SO42- and Cl- were added to the phosphate solution.
32574733	2	47	theme	group	563:567	arg1	composition					569:579	functional group composition	552:579	functional group composition	552:579	Various characterization methods like SEM, FTIR, XRD and XPS were adopted to examine the morphology and functional group composition of SA-La@PEI.
32574733	1	48	theme	engineering	417:427	arg1	strategies					335:344	combing strategies	327:344	combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads	327:445	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	6	49	theme	low-cost	1194:1201	arg1	performance					1225:1235	its low-cost, excellent adsorption performance	1190:1235	its low-cost, excellent adsorption performance	1190:1235	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	6	50	theme	adsorption	1214:1223	arg1	performance					1225:1235	its low-cost, excellent adsorption performance	1190:1235	its low-cost, excellent adsorption performance	1190:1235	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	6	51	dep	low-cost	1194:1201	arg1	excellent					1204:1212	excellent	1204:1212	excellent	1204:1212	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	1	52	theme	environmental	227:239	arg1	friendly					241:248	an environmental friendly	224:248	an environmental friendly	224:248	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	2	53	theme	functional	552:561	arg1	composition					569:579	functional group composition	552:579	functional group composition	552:579	Various characterization methods like SEM, FTIR, XRD and XPS were adopted to examine the morphology and functional group composition of SA-La@PEI.
32574733	3	54	theme	excellent	639:647	arg1	performance					660:670	excellent adsorption performance	639:670	excellent adsorption performance of 121.2 mg/g, which was better than most published materials	639:732	Through detailed tests, SA-La@PEI exhibited excellent adsorption performance of 121.2 mg/g, which was better than most published materials.
32574733	5	55	theme	electrostatic	971:983	arg1	attraction					985:994	electrostatic attraction	971:994	electrostatic attraction	971:994	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	5	55	theme	electrostatic	971:983	arg1	mechanisms					1030:1039	the dominant mechanisms	1017:1039	the dominant mechanisms of phosphate adsorption	1017:1063	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	5	55	theme	electrostatic	971:983	arg1	precipitation					953:965	chemical precipitation	944:965	chemical precipitation	944:965	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	1	56	theme	friendly	241:248	arg1	discharge					200:208	excessive discharge	190:208	excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate	190:307	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	0	57	theme	sorption	71:78	arg1	component					89:97	sorption affinity component	71:97	sorption affinity component for enhanced phosphate capture	71:128	Network interior and surface engineering of alginate-based beads using sorption affinity component for enhanced phosphate capture.
32574733	1	58	theme	alginate	432:439	arg1	beads					441:445	alginate beads	432:445	alginate beads	432:445	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	4	59	theme	@	799:799	arg1	PEI					800:802	SA-La@PEI	794:802	SA-La@PEI	794:802	More importantly, the outstanding phosphate selectivity of SA-La@PEI was exposed when NO3-, HCO3-, SO42- and Cl- were added to the phosphate solution.
32574733	6	60	theme	PEI	1093:1095	arg1	sorbent					1124:1130	a promising sorbent	1112:1130	a promising sorbent for the decontamination of excessive phosphate	1112:1177	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	6	60	theme	PEI	1093:1095	arg1	beads					1097:1101	as-prepared SA-La@PEI beads	1075:1101	as-prepared SA-La@PEI beads	1075:1101	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	5	61	from	components	913:922	arg1	composites					927:936	composites	927:936	composites	927:936	Considering the integrated components in composites, both chemical precipitation and electrostatic attraction can be considered as the dominant mechanisms of phosphate adsorption.
32574733	1	62	theme	combing	327:333	arg1	strategies					335:344	combing strategies	327:344	combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads	327:445	In order to alleviate the environmental problems caused by excessive discharge of phosphate, an environmental friendly and highly efficient bio-sorbent (SA-La@PEI) for phosphate was fabricated by combing strategies of sorption affinity component mediated and poly(ethylenimine) surface engineering of alginate beads.
32574733	3	63	theme	detailed	603:610	arg1	tests					612:616	detailed tests	603:616	detailed tests	603:616	Through detailed tests, SA-La@PEI exhibited excellent adsorption performance of 121.2 mg/g, which was better than most published materials.
32574733	6	64	theme	@	1092:1092	arg1	sorbent					1124:1130	a promising sorbent	1112:1130	a promising sorbent for the decontamination of excessive phosphate	1112:1177	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
32574733	6	64	theme	@	1092:1092	arg1	beads					1097:1101	as-prepared SA-La@PEI beads	1075:1101	as-prepared SA-La@PEI beads	1075:1101	Totally, as-prepared SA-La@PEI beads might be a promising sorbent for the decontamination of excessive phosphate because of its low-cost, excellent adsorption performance and mechanical strength.
34415569	0	0	theme	invasive	73:80	arg1	shrub					82:86	an invasive shrub	70:86	an invasive shrub	70:86	Episodic defoliation rapidly reduces starch but not soluble sugars in an invasive shrub, Tamarix spp.
34415569	1	1	theme	foliage	294:300	arg1	herbivory					302:310	foliage herbivory	294:310	foliage herbivory	294:310	PREMISE Plants rely on pools of internal nonstructural carbohydrates (NSCs: soluble sugars plus starch) to support metabolism, growth, and regrowth of tissues damaged from disturbance such as foliage herbivory.
34415569	7	2	dep	RESULTS	1137:1143	arg1	had					1157:1159	had	1157:1159	had no impact on either above- or belowground soluble sugar pools	1157:1221	RESULTS Defoliation had no impact on either above- or belowground soluble sugar pools.
34415569	2	3	from	composition	371:381	arg1	plants					416:421	long-lived woody plants	399:421	long-lived woody plants	399:421	However, impacts of foliage herbivory on the quantity and composition of NSC pools in long-lived woody plants are currently unclear.
34415569	5	4	theme	cylinder	908:915	arg1	mesocosms					917:925	eight cylinder mesocosms	902:925	eight cylinder mesocosms (2 m diameter, 1 m in depth)	902:954	METHODS Hypotheses were tested by transplanting six Tamarix seedlings into each of eight cylinder mesocosms (2 m diameter, 1 m in depth).
34415569	5	5	theme	2 m	928:930	arg1	1 m					942:944	1 m	942:944	1 m in depth	942:953	METHODS Hypotheses were tested by transplanting six Tamarix seedlings into each of eight cylinder mesocosms (2 m diameter, 1 m in depth).
34415569	5	5	theme	2 m	928:930	arg1	diameter					932:939	2 m diameter	928:939	2 m diameter	928:939	METHODS Hypotheses were tested by transplanting six Tamarix seedlings into each of eight cylinder mesocosms (2 m diameter, 1 m in depth).
34415569	10	6	theme	foliage	1795:1801	arg1	herbivory					1803:1811	foliage herbivory	1795:1811	foliage herbivory	1795:1811	These results improve our understanding of how woody plants cope with episodic defoliation caused by foliage herbivory and other disturbances.
34415569	7	7	contain	had	1157:1159	arg1	Defoliation					1145:1155	Defoliation	1145:1155	Defoliation	1145:1155	RESULTS Defoliation had no impact on either above- or belowground soluble sugar pools.
34415569	7	7	contain	had	1157:1159	arg2	impact					1164:1169	no impact	1161:1169	no impact	1161:1169	RESULTS Defoliation had no impact on either above- or belowground soluble sugar pools.
34415569	8	8	from	%	1274:1274	arg1	roots					1297:1301	roots	1297:1301	roots	1297:1301	However, starch in defoliated plants dropped to 55% and 26% in stems and roots, respectively, relative to control plants, resulting in an over 2-fold higher soluble sugar to starch ratio in defoliated plants.
34415569	8	8	from	%	1274:1274	arg1	stems					1287:1291	stems	1287:1291	stems	1287:1291	However, starch in defoliated plants dropped to 55% and 26% in stems and roots, respectively, relative to control plants, resulting in an over 2-fold higher soluble sugar to starch ratio in defoliated plants.
34415569	1	9	theme	internal	134:141	arg1	carbohydrates					157:169	internal nonstructural carbohydrates	134:169	internal nonstructural carbohydrates (NSCs: soluble sugars plus starch)	134:204	PREMISE Plants rely on pools of internal nonstructural carbohydrates (NSCs: soluble sugars plus starch) to support metabolism, growth, and regrowth of tissues damaged from disturbance such as foliage herbivory.
34415569	9	10	theme	depleted	1591:1598	arg1	starch					1600:1605	depleted starch	1591:1605	depleted starch	1591:1605	CONCLUSIONS The results suggest that defoliation occurring over a single growing season does not impact immediate plant functions such as osmoregulation, but depleted starch could limit future fitness, particularly where defoliation occurs over multiple years.
34415569	3	11	theme	Tamarix	507:513	arg1	shrub/tree					546:555	mature Tamarix spp.-a dominant riparian woody shrub/tree	500:555	mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses	500:640	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	8	12	theme	relative	1318:1325	arg1	%					1274:1274	55%	1272:1274	55%	1272:1274	However, starch in defoliated plants dropped to 55% and 26% in stems and roots, respectively, relative to control plants, resulting in an over 2-fold higher soluble sugar to starch ratio in defoliated plants.
34415569	7	13	theme	above-	1181:1186	arg1	pools					1217:1221	either above- or belowground soluble sugar pools	1174:1221	either above- or belowground soluble sugar pools	1174:1221	RESULTS Defoliation had no impact on either above- or belowground soluble sugar pools.
34415569	3	14	theme	NSC	726:728	arg1	storage					730:736	belowground NSC storage	714:736	belowground NSC storage	714:736	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	7	15	theme	belowground	1191:1201	arg1	pools					1217:1221	either above- or belowground soluble sugar pools	1174:1221	either above- or belowground soluble sugar pools	1174:1221	RESULTS Defoliation had no impact on either above- or belowground soluble sugar pools.
34415569	8	16	from	starch	1233:1238	arg1	plants					1254:1259	defoliated plants	1243:1259	defoliated plants	1243:1259	However, starch in defoliated plants dropped to 55% and 26% in stems and roots, respectively, relative to control plants, resulting in an over 2-fold higher soluble sugar to starch ratio in defoliated plants.
34415569	3	17	theme	spp.-a	515:520	arg1	shrub/tree					546:555	mature Tamarix spp.-a dominant riparian woody shrub/tree	500:555	mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses	500:640	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	8	18	from	ratio	1405:1409	arg1	plants					1425:1430	defoliated plants	1414:1430	defoliated plants	1414:1430	However, starch in defoliated plants dropped to 55% and 26% in stems and roots, respectively, relative to control plants, resulting in an over 2-fold higher soluble sugar to starch ratio in defoliated plants.
34415569	6	19	from	plants	974:979	arg1	four					984:987	four	984:987	four	984:987	After 2.5 years, plants in four of the eight mesocosms were mechanically defoliated repeatedly over a single growing season, and all plants were harvested in the following spring.
34415569	6	19	from	plants	974:979	arg1	mesocosms					1002:1010	the eight mesocosms	992:1010	the eight mesocosms	992:1010	After 2.5 years, plants in four of the eight mesocosms were mechanically defoliated repeatedly over a single growing season, and all plants were harvested in the following spring.
34415569	3	20	from	experiment	486:495	arg1	shrub/tree					546:555	mature Tamarix spp.-a dominant riparian woody shrub/tree	500:555	mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses	500:640	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	4	21	theme	starch	782:787	arg1	storage					810:816	starch versus soluble sugar storage	782:816	starch versus soluble sugar storage	782:816	(2) Defoliation disproportionately impacts starch versus soluble sugar storage.
34415569	1	22	theme	nonstructural	143:155	arg1	carbohydrates					157:169	internal nonstructural carbohydrates	134:169	internal nonstructural carbohydrates (NSCs: soluble sugars plus starch)	134:204	PREMISE Plants rely on pools of internal nonstructural carbohydrates (NSCs: soluble sugars plus starch) to support metabolism, growth, and regrowth of tissues damaged from disturbance such as foliage herbivory.
34415569	9	23	theme	future	1619:1624	arg1	fitness					1626:1632	future fitness	1619:1632	future fitness	1619:1632	CONCLUSIONS The results suggest that defoliation occurring over a single growing season does not impact immediate plant functions such as osmoregulation, but depleted starch could limit future fitness, particularly where defoliation occurs over multiple years.
34415569	3	24	theme	mature	500:505	arg1	shrub/tree					546:555	mature Tamarix spp.-a dominant riparian woody shrub/tree	500:555	mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses	500:640	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	8	25	theme	control	1330:1336	arg1	plants					1338:1343	control plants	1330:1343	control plants	1330:1343	However, starch in defoliated plants dropped to 55% and 26% in stems and roots, respectively, relative to control plants, resulting in an over 2-fold higher soluble sugar to starch ratio in defoliated plants.
34415569	1	26	theme	carbohydrates	157:169	arg1	pools					125:129	pools	125:129	pools of internal nonstructural carbohydrates (NSCs: soluble sugars plus starch)	125:204	PREMISE Plants rely on pools of internal nonstructural carbohydrates (NSCs: soluble sugars plus starch) to support metabolism, growth, and regrowth of tissues damaged from disturbance such as foliage herbivory.
34415569	2	27	theme	long-lived	399:408	arg1	plants					416:421	long-lived woody plants	399:421	long-lived woody plants	399:421	However, impacts of foliage herbivory on the quantity and composition of NSC pools in long-lived woody plants are currently unclear.
34415569	3	28	theme	belowground	714:724	arg1	storage					730:736	belowground NSC storage	714:736	belowground NSC storage	714:736	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	6	29	theme	growing	1066:1072	arg1	season					1074:1079	a single growing season	1057:1079	a single growing season	1057:1079	After 2.5 years, plants in four of the eight mesocosms were mechanically defoliated repeatedly over a single growing season, and all plants were harvested in the following spring.
34415569	8	30	from	%	1282:1282	arg1	roots					1297:1301	roots	1297:1301	roots	1297:1301	However, starch in defoliated plants dropped to 55% and 26% in stems and roots, respectively, relative to control plants, resulting in an over 2-fold higher soluble sugar to starch ratio in defoliated plants.
34415569	8	30	from	%	1282:1282	arg1	stems					1287:1291	stems	1287:1291	stems	1287:1291	However, starch in defoliated plants dropped to 55% and 26% in stems and roots, respectively, relative to control plants, resulting in an over 2-fold higher soluble sugar to starch ratio in defoliated plants.
34415569	3	31	theme	woody	540:544	arg1	shrub/tree					546:555	mature Tamarix spp.-a dominant riparian woody shrub/tree	500:555	mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses	500:640	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	2	32	theme	herbivory	341:349	arg1	impacts					322:328	impacts	322:328	impacts of foliage herbivory on the quantity and composition of NSC pools in long-lived woody plants	322:421	However, impacts of foliage herbivory on the quantity and composition of NSC pools in long-lived woody plants are currently unclear.
34415569	0	33	theme	Episodic	0:7	arg1	defoliation					9:19	Episodic defoliation	0:19	Episodic defoliation	0:19	Episodic defoliation rapidly reduces starch but not soluble sugars in an invasive shrub, Tamarix spp.
34415569	9	34	theme	growing	1506:1512	arg1	season					1514:1519	a single growing season	1497:1519	a single growing season	1497:1519	CONCLUSIONS The results suggest that defoliation occurring over a single growing season does not impact immediate plant functions such as osmoregulation, but depleted starch could limit future fitness, particularly where defoliation occurs over multiple years.
34415569	5	35	dep	mesocosms	917:925	arg1	1 m					942:944	1 m	942:944	1 m in depth	942:953	METHODS Hypotheses were tested by transplanting six Tamarix seedlings into each of eight cylinder mesocosms (2 m diameter, 1 m in depth).
34415569	5	35	dep	mesocosms	917:925	arg1	diameter					932:939	2 m diameter	928:939	2 m diameter	928:939	METHODS Hypotheses were tested by transplanting six Tamarix seedlings into each of eight cylinder mesocosms (2 m diameter, 1 m in depth).
34415569	2	36	theme	foliage	333:339	arg1	herbivory					341:349	foliage herbivory	333:349	foliage herbivory	333:349	However, impacts of foliage herbivory on the quantity and composition of NSC pools in long-lived woody plants are currently unclear.
34415569	2	37	theme	pools	390:394	arg1	composition					371:381	composition	371:381	composition	371:381	However, impacts of foliage herbivory on the quantity and composition of NSC pools in long-lived woody plants are currently unclear.
34415569	2	37	theme	pools	390:394	arg1	quantity					358:365	quantity	358:365	quantity	358:365	However, impacts of foliage herbivory on the quantity and composition of NSC pools in long-lived woody plants are currently unclear.
34415569	5	38	theme	METHODS	819:825	arg1	Hypotheses					827:836	METHODS Hypotheses	819:836	METHODS Hypotheses	819:836	METHODS Hypotheses were tested by transplanting six Tamarix seedlings into each of eight cylinder mesocosms (2 m diameter, 1 m in depth).
34415569	2	39	from	impacts	322:328	arg1	composition					371:381	composition	371:381	composition	371:381	However, impacts of foliage herbivory on the quantity and composition of NSC pools in long-lived woody plants are currently unclear.
34415569	2	39	from	impacts	322:328	arg1	quantity					358:365	quantity	358:365	quantity	358:365	However, impacts of foliage herbivory on the quantity and composition of NSC pools in long-lived woody plants are currently unclear.
34415569	3	40	theme	dominant	522:529	arg1	shrub/tree					546:555	mature Tamarix spp.-a dominant riparian woody shrub/tree	500:555	mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses	500:640	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	10	41	theme	episodic	1764:1771	arg1	defoliation					1773:1783	episodic defoliation	1764:1783	episodic defoliation caused by foliage herbivory and other disturbances	1764:1834	These results improve our understanding of how woody plants cope with episodic defoliation caused by foliage herbivory and other disturbances.
34415569	2	42	theme	NSC	386:388	arg1	pools					390:394	NSC pools	386:394	NSC pools	386:394	However, impacts of foliage herbivory on the quantity and composition of NSC pools in long-lived woody plants are currently unclear.
34415569	3	43	dep	impacts	687:693	arg1	1					644:644	1	644:644	1	644:644	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	8	44	theme	soluble	1381:1387	arg1	sugar					1389:1393	2-fold higher soluble sugar	1367:1393	2-fold higher soluble sugar to starch ratio in defoliated plants	1367:1430	However, starch in defoliated plants dropped to 55% and 26% in stems and roots, respectively, relative to control plants, resulting in an over 2-fold higher soluble sugar to starch ratio in defoliated plants.
34415569	3	45	theme	riparian	531:538	arg1	shrub/tree					546:555	mature Tamarix spp.-a dominant riparian woody shrub/tree	500:555	mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses	500:640	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	1	46	theme	soluble	178:184	arg1	sugars					186:191	soluble sugars	178:191	soluble sugars	178:191	PREMISE Plants rely on pools of internal nonstructural carbohydrates (NSCs: soluble sugars plus starch) to support metabolism, growth, and regrowth of tissues damaged from disturbance such as foliage herbivory.
34415569	1	47	theme	tissues	253:259	arg1	growth					229:234	growth	229:234	growth	229:234	PREMISE Plants rely on pools of internal nonstructural carbohydrates (NSCs: soluble sugars plus starch) to support metabolism, growth, and regrowth of tissues damaged from disturbance such as foliage herbivory.
34415569	1	47	theme	tissues	253:259	arg1	regrowth					241:248	regrowth	241:248	regrowth	241:248	PREMISE Plants rely on pools of internal nonstructural carbohydrates (NSCs: soluble sugars plus starch) to support metabolism, growth, and regrowth of tissues damaged from disturbance such as foliage herbivory.
34415569	1	47	theme	tissues	253:259	arg1	metabolism					217:226	metabolism	217:226	metabolism	217:226	PREMISE Plants rely on pools of internal nonstructural carbohydrates (NSCs: soluble sugars plus starch) to support metabolism, growth, and regrowth of tissues damaged from disturbance such as foliage herbivory.
34415569	8	48	theme	higher	1374:1379	arg1	sugar					1389:1393	2-fold higher soluble sugar	1367:1393	2-fold higher soluble sugar to starch ratio in defoliated plants	1367:1430	However, starch in defoliated plants dropped to 55% and 26% in stems and roots, respectively, relative to control plants, resulting in an over 2-fold higher soluble sugar to starch ratio in defoliated plants.
34415569	9	49	theme	immediate	1537:1545	arg1	functions					1553:1561	immediate plant functions	1537:1561	immediate plant functions such as osmoregulation	1537:1584	CONCLUSIONS The results suggest that defoliation occurring over a single growing season does not impact immediate plant functions such as osmoregulation, but depleted starch could limit future fitness, particularly where defoliation occurs over multiple years.
34415569	9	49	theme	immediate	1537:1545	arg1	osmoregulation					1571:1584	osmoregulation	1571:1584	osmoregulation	1571:1584	CONCLUSIONS The results suggest that defoliation occurring over a single growing season does not impact immediate plant functions such as osmoregulation, but depleted starch could limit future fitness, particularly where defoliation occurs over multiple years.
34415569	3	50	dep	pressure-to	597:607	arg1	test					609:612	test	609:612	test two interrelated hypotheses	609:640	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	5	51	theme	Tamarix	871:877	arg1	seedlings					879:887	six Tamarix seedlings	867:887	six Tamarix seedlings	867:887	METHODS Hypotheses were tested by transplanting six Tamarix seedlings into each of eight cylinder mesocosms (2 m diameter, 1 m in depth).
34415569	2	52	dep	quantity	358:365	arg1	the					354:356	the	354:356	the	354:356	However, impacts of foliage herbivory on the quantity and composition of NSC pools in long-lived woody plants are currently unclear.
34415569	8	53	theme	defoliated	1243:1252	arg1	plants					1254:1259	defoliated plants	1243:1259	defoliated plants	1243:1259	However, starch in defoliated plants dropped to 55% and 26% in stems and roots, respectively, relative to control plants, resulting in an over 2-fold higher soluble sugar to starch ratio in defoliated plants.
34415569	0	54	theme	soluble	52:58	arg1	sugars					60:65	soluble sugars	52:65	starch but not soluble sugars	37:65	Episodic defoliation rapidly reduces starch but not soluble sugars in an invasive shrub, Tamarix spp.
34415569	3	55	theme	interrelated	618:629	arg1	hypotheses					631:640	two interrelated hypotheses	614:640	two interrelated hypotheses	614:640	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	9	56	theme	plant	1547:1551	arg1	functions					1553:1561	immediate plant functions	1537:1561	immediate plant functions such as osmoregulation	1537:1584	CONCLUSIONS The results suggest that defoliation occurring over a single growing season does not impact immediate plant functions such as osmoregulation, but depleted starch could limit future fitness, particularly where defoliation occurs over multiple years.
34415569	9	56	theme	plant	1547:1551	arg1	osmoregulation					1571:1584	osmoregulation	1571:1584	osmoregulation	1571:1584	CONCLUSIONS The results suggest that defoliation occurring over a single growing season does not impact immediate plant functions such as osmoregulation, but depleted starch could limit future fitness, particularly where defoliation occurs over multiple years.
34415569	10	57	theme	other	1817:1821	arg1	disturbances					1823:1834	other disturbances	1817:1834	other disturbances	1817:1834	These results improve our understanding of how woody plants cope with episodic defoliation caused by foliage herbivory and other disturbances.
34415569	2	58	theme	woody	410:414	arg1	plants					416:421	long-lived woody plants	399:421	long-lived woody plants	399:421	However, impacts of foliage herbivory on the quantity and composition of NSC pools in long-lived woody plants are currently unclear.
34415569	9	59	theme	multiple	1678:1685	arg1	years					1687:1691	multiple years	1678:1691	multiple years	1678:1691	CONCLUSIONS The results suggest that defoliation occurring over a single growing season does not impact immediate plant functions such as osmoregulation, but depleted starch could limit future fitness, particularly where defoliation occurs over multiple years.
34415569	1	60	dep	carbohydrates	157:169	arg1	NSCs					172:175	NSCs	172:175	NSCs: soluble sugars plus starch	172:203	PREMISE Plants rely on pools of internal nonstructural carbohydrates (NSCs: soluble sugars plus starch) to support metabolism, growth, and regrowth of tissues damaged from disturbance such as foliage herbivory.
34415569	3	61	theme	controlled	463:472	arg1	experiment					486:495	a controlled defoliation experiment	461:495	a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses	461:640	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	1	62	theme	PREMISE	102:108	arg1	Plants					110:115	PREMISE Plants	102:115	PREMISE Plants	102:115	PREMISE Plants rely on pools of internal nonstructural carbohydrates (NSCs: soluble sugars plus starch) to support metabolism, growth, and regrowth of tissues damaged from disturbance such as foliage herbivory.
34415569	4	63	theme	sugar	804:808	arg1	storage					810:816	starch versus soluble sugar storage	782:816	starch versus soluble sugar storage	782:816	(2) Defoliation disproportionately impacts starch versus soluble sugar storage.
34415569	3	64	theme	Repeated	647:654	arg1	defoliation					656:666	Repeated defoliation	647:666	Repeated defoliation	647:666	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	4	65	theme	soluble	796:802	arg1	storage					810:816	starch versus soluble sugar storage	782:816	starch versus soluble sugar storage	782:816	(2) Defoliation disproportionately impacts starch versus soluble sugar storage.
34415569	1	66	dep	NSCs	172:175	arg1	starch					198:203	starch	198:203	starch	198:203	PREMISE Plants rely on pools of internal nonstructural carbohydrates (NSCs: soluble sugars plus starch) to support metabolism, growth, and regrowth of tissues damaged from disturbance such as foliage herbivory.
34415569	1	66	dep	NSCs	172:175	arg1	sugars					186:191	soluble sugars	178:191	soluble sugars	178:191	PREMISE Plants rely on pools of internal nonstructural carbohydrates (NSCs: soluble sugars plus starch) to support metabolism, growth, and regrowth of tissues damaged from disturbance such as foliage herbivory.
34415569	6	67	theme	following	1119:1127	arg1	spring					1129:1134	the following spring	1115:1134	the following spring	1115:1134	After 2.5 years, plants in four of the eight mesocosms were mechanically defoliated repeatedly over a single growing season, and all plants were harvested in the following spring.
34415569	6	68	theme	mesocosms	1002:1010	arg1	four					984:987	four	984:987	four	984:987	After 2.5 years, plants in four of the eight mesocosms were mechanically defoliated repeatedly over a single growing season, and all plants were harvested in the following spring.
34415569	6	68	theme	mesocosms	1002:1010	arg1	mesocosms					1002:1010	the eight mesocosms	992:1010	the eight mesocosms	992:1010	After 2.5 years, plants in four of the eight mesocosms were mechanically defoliated repeatedly over a single growing season, and all plants were harvested in the following spring.
34415569	9	69	theme	single	1499:1504	arg1	season					1514:1519	a single growing season	1497:1519	a single growing season	1497:1519	CONCLUSIONS The results suggest that defoliation occurring over a single growing season does not impact immediate plant functions such as osmoregulation, but depleted starch could limit future fitness, particularly where defoliation occurs over multiple years.
34415569	8	70	theme	defoliated	1414:1423	arg1	plants					1425:1430	defoliated plants	1414:1430	defoliated plants	1414:1430	However, starch in defoliated plants dropped to 55% and 26% in stems and roots, respectively, relative to control plants, resulting in an over 2-fold higher soluble sugar to starch ratio in defoliated plants.
34415569	9	71	dep	CONCLUSIONS	1433:1443	arg1	suggest					1457:1463	suggest	1457:1463	suggest that defoliation occurring over a single growing season does not impact immediate plant functions such as osmoregulation, but depleted starch could limit future fitness, particularly where defoliation occurs over multiple years.	1457:1692	CONCLUSIONS The results suggest that defoliation occurring over a single growing season does not impact immediate plant functions such as osmoregulation, but depleted starch could limit future fitness, particularly where defoliation occurs over multiple years.
34415569	8	72	theme	starch	1398:1403	arg1	ratio					1405:1409	starch ratio	1398:1409	starch ratio in defoliated plants	1398:1430	However, starch in defoliated plants dropped to 55% and 26% in stems and roots, respectively, relative to control plants, resulting in an over 2-fold higher soluble sugar to starch ratio in defoliated plants.
34415569	5	73	from	1 m	942:944	arg1	depth					949:953	depth	949:953	depth	949:953	METHODS Hypotheses were tested by transplanting six Tamarix seedlings into each of eight cylinder mesocosms (2 m diameter, 1 m in depth).
34415569	10	74	theme	woody	1741:1745	arg1	plants					1747:1752	woody plants	1741:1752	woody plants	1741:1752	These results improve our understanding of how woody plants cope with episodic defoliation caused by foliage herbivory and other disturbances.
34415569	7	75	theme	soluble	1203:1209	arg1	pools					1217:1221	either above- or belowground soluble sugar pools	1174:1221	either above- or belowground soluble sugar pools	1174:1221	RESULTS Defoliation had no impact on either above- or belowground soluble sugar pools.
34415569	3	76	theme	intense	579:585	arg1	pressure-to					597:607	intense herbivory pressure-to	579:607	intense herbivory pressure-to test two interrelated hypotheses	579:640	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	2	77	from	quantity	358:365	arg1	plants					416:421	long-lived woody plants	399:421	long-lived woody plants	399:421	However, impacts of foliage herbivory on the quantity and composition of NSC pools in long-lived woody plants are currently unclear.
34415569	3	78	theme	defoliation	474:484	arg1	experiment					486:495	a controlled defoliation experiment	461:495	a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses	461:640	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	6	79	theme	single	1059:1064	arg1	season					1074:1079	a single growing season	1057:1079	a single growing season	1057:1079	After 2.5 years, plants in four of the eight mesocosms were mechanically defoliated repeatedly over a single growing season, and all plants were harvested in the following spring.
34415569	7	80	theme	sugar	1211:1215	arg1	pools					1217:1221	either above- or belowground soluble sugar pools	1174:1221	either above- or belowground soluble sugar pools	1174:1221	RESULTS Defoliation had no impact on either above- or belowground soluble sugar pools.
34415569	3	81	theme	herbivory	587:595	arg1	pressure-to					597:607	intense herbivory pressure-to	579:607	intense herbivory pressure-to test two interrelated hypotheses	579:640	We implemented a controlled defoliation experiment on mature Tamarix spp.-a dominant riparian woody shrub/tree that has evolved with intense herbivory pressure-to test two interrelated hypotheses: (1) Repeated defoliation disproportionately impacts aboveground versus belowground NSC storage.
34415569	4	82	dep	impacts	774:780	arg1	2					740:740	2	740:740	2	740:740	(2) Defoliation disproportionately impacts starch versus soluble sugar storage.
34128589	0	0	theme	Modified	101:108	arg1	Chitosan					110:117	Chitosan	110:117	Chitosan	110:117	Long-Term Controlled Release of Simvastatin from Photoprinted Triple-Networked Hydrogels Composed of Modified Chitosan and PLA-PEG Micelles.
34128589	6	1	theme	ethylene	1061:1068	arg1	glycol					1070:1075	ethylene glycol	1061:1075	ethylene glycol	1061:1075	SMV is loaded into polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA) and mixed with N-methacryloyl chitosan and PEG dimethacrylate to fabricate hydrogels by photo-cross-linked 3D printing.
34128589	6	2	theme	triblock	1078:1085	arg1	PLA-PEG-PLA					1099:1109	PLA-PEG-PLA	1099:1109	PLA-PEG-PLA	1099:1109	SMV is loaded into polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA) and mixed with N-methacryloyl chitosan and PEG dimethacrylate to fabricate hydrogels by photo-cross-linked 3D printing.
34128589	6	2	theme	triblock	1078:1085	arg1	copolymers					1087:1096	polylactide/poly(ethylene glycol) triblock copolymers	1044:1096	polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA)	1044:1110	SMV is loaded into polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA) and mixed with N-methacryloyl chitosan and PEG dimethacrylate to fabricate hydrogels by photo-cross-linked 3D printing.
34128589	7	3	theme	polymer	1323:1329	arg1	compositions					1331:1342	the polymer compositions	1319:1342	the polymer compositions	1319:1342	The hydrogel properties and drug release profiles have shown significant dependance on the polymer compositions.
34128589	5	4	from	effect	826:831	arg1	hydrogels					890:898	3D-printed triple-network hydrogels	864:898	3D-printed triple-network hydrogels for osteogenic stimulation	864:925	This study assesses the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant.
34128589	10	5	theme	therapeutic	1589:1599	arg1	value					1601:1605	a potential therapeutic value	1577:1605	a potential therapeutic value for bone regeneration	1577:1627	The tunable triple-network hydrogels loaded with SMV provide a potential therapeutic value for bone regeneration.
34128589	1	6	theme	injectable	179:188	arg1	hydrogels					205:213	injectable or implantable hydrogels	179:213	injectable or implantable hydrogels for tissue and bone regeneration	179:246	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration is a promising therapy, but it remains challenging for controlling dose and duration of release.
34128589	7	7	theme	drug	1260:1263	arg1	profiles					1273:1280	drug release profiles	1260:1280	drug release profiles	1260:1280	The hydrogel properties and drug release profiles have shown significant dependance on the polymer compositions.
34128589	10	8	theme	potential	1579:1587	arg1	value					1601:1605	a potential therapeutic value	1577:1605	a potential therapeutic value for bone regeneration	1577:1627	The tunable triple-network hydrogels loaded with SMV provide a potential therapeutic value for bone regeneration.
34128589	10	9	theme	triple-network	1528:1541	arg1	hydrogels					1543:1551	The tunable triple-network hydrogels	1516:1551	The tunable triple-network hydrogels loaded with SMV	1516:1567	The tunable triple-network hydrogels loaded with SMV provide a potential therapeutic value for bone regeneration.
34128589	5	10	theme	biological	966:975	arg1	properties					977:986	their mechanical and biological properties	945:986	their mechanical and biological properties	945:986	This study assesses the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant.
34128589	5	10	theme	biological	966:975	arg1	implant					994:1000	an implant	991:1000	an implant	991:1000	This study assesses the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant.
34128589	6	11	theme	polylactide/poly	1044:1059	arg1	PLA-PEG-PLA					1099:1109	PLA-PEG-PLA	1099:1109	PLA-PEG-PLA	1099:1109	SMV is loaded into polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA) and mixed with N-methacryloyl chitosan and PEG dimethacrylate to fabricate hydrogels by photo-cross-linked 3D printing.
34128589	6	11	theme	polylactide/poly	1044:1059	arg1	copolymers					1087:1096	polylactide/poly(ethylene glycol) triblock copolymers	1044:1096	polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA)	1044:1110	SMV is loaded into polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA) and mixed with N-methacryloyl chitosan and PEG dimethacrylate to fabricate hydrogels by photo-cross-linked 3D printing.
34128589	10	12	theme	tunable	1520:1526	arg1	hydrogels					1543:1551	The tunable triple-network hydrogels	1516:1551	The tunable triple-network hydrogels loaded with SMV	1516:1567	The tunable triple-network hydrogels loaded with SMV provide a potential therapeutic value for bone regeneration.
34128589	5	13	theme	osteogenic	904:913	arg1	stimulation					915:925	osteogenic stimulation	904:925	osteogenic stimulation	904:925	This study assesses the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant.
34128589	3	14	theme	physical	471:478	arg1	interactions					480:491	physical interactions	471:491	physical interactions	471:491	Secure loading of hydrophobic drugs by physical interactions is particularly difficult to establish in hydrophilic polymer matrices, and their sustained release over several months for long-term regeneration has rarely been reported.
34128589	3	15	theme	polymer	547:553	arg1	matrices					555:562	hydrophilic polymer matrices	535:562	hydrophilic polymer matrices	535:562	Secure loading of hydrophobic drugs by physical interactions is particularly difficult to establish in hydrophilic polymer matrices, and their sustained release over several months for long-term regeneration has rarely been reported.
34128589	8	16	from	hydrogel	1393:1400	arg1	release					1353:1359	The SMV release	1345:1359	The SMV release from the triple-polymer-network hydrogel	1345:1400	The SMV release from the triple-polymer-network hydrogel has continued for 17 weeks of observation.
34128589	8	17	theme	SMV	1349:1351	arg1	release					1353:1359	The SMV release	1345:1359	The SMV release from the triple-polymer-network hydrogel	1345:1400	The SMV release from the triple-polymer-network hydrogel has continued for 17 weeks of observation.
34128589	0	18	theme	PLA-PEG	123:129	arg1	Micelles					131:138	PLA-PEG Micelles	123:138	PLA-PEG Micelles	123:138	Long-Term Controlled Release of Simvastatin from Photoprinted Triple-Networked Hydrogels Composed of Modified Chitosan and PLA-PEG Micelles.
34128589	5	19	theme	release	851:857	arg1	effect					826:831	the effect	822:831	the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation	822:925	This study assesses the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant.
34128589	9	20	with	Cytocompatibility	1445:1461	arg1	formulations					1489:1500	various formulations	1481:1500	various formulations	1481:1500	Cytocompatibility of hydrogels with various formulations is confirmed.
34128589	1	21	theme	implantable	193:203	arg1	hydrogels					205:213	injectable or implantable hydrogels	179:213	injectable or implantable hydrogels for tissue and bone regeneration	179:246	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration is a promising therapy, but it remains challenging for controlling dose and duration of release.
34128589	0	22	theme	Controlled	10:19	arg1	Release					21:27	Long-Term Controlled Release	0:27	Long-Term Controlled Release of Simvastatin from Photoprinted Triple-Networked Hydrogels	0:87	Long-Term Controlled Release of Simvastatin from Photoprinted Triple-Networked Hydrogels Composed of Modified Chitosan and PLA-PEG Micelles.
34128589	10	23	theme	bone	1611:1614	arg1	regeneration					1616:1627	bone regeneration	1611:1627	bone regeneration	1611:1627	The tunable triple-network hydrogels loaded with SMV provide a potential therapeutic value for bone regeneration.
34128589	4	24	theme	eventual	775:782	arg1	biodegradability					784:799	eventual biodegradability	775:799	eventual biodegradability	775:799	Additionally, mechanical properties of hydrogels must be improved for a sufficient support while maintaining eventual biodegradability.
34128589	4	25	theme	hydrogels	705:713	arg1	properties					691:700	mechanical properties	680:700	mechanical properties of hydrogels	680:713	Additionally, mechanical properties of hydrogels must be improved for a sufficient support while maintaining eventual biodegradability.
34128589	0	26	theme	Long-Term	0:8	arg1	Release					21:27	Long-Term Controlled Release	0:27	Long-Term Controlled Release of Simvastatin from Photoprinted Triple-Networked Hydrogels	0:87	Long-Term Controlled Release of Simvastatin from Photoprinted Triple-Networked Hydrogels Composed of Modified Chitosan and PLA-PEG Micelles.
34128589	3	27	theme	Secure	432:437	arg1	loading					439:445	Secure loading	432:445	Secure loading of hydrophobic drugs by physical interactions	432:491	Secure loading of hydrophobic drugs by physical interactions is particularly difficult to establish in hydrophilic polymer matrices, and their sustained release over several months for long-term regeneration has rarely been reported.
34128589	5	28	theme	3D-printed	864:873	arg1	hydrogels					890:898	3D-printed triple-network hydrogels	864:898	3D-printed triple-network hydrogels for osteogenic stimulation	864:925	This study assesses the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant.
34128589	6	29	theme	PEG	1155:1157	arg1	dimethacrylate					1159:1172	PEG dimethacrylate	1155:1172	PEG dimethacrylate	1155:1172	SMV is loaded into polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA) and mixed with N-methacryloyl chitosan and PEG dimethacrylate to fabricate hydrogels by photo-cross-linked 3D printing.
34128589	1	30	theme	tissue	219:224	arg1	regeneration					235:246	tissue and bone regeneration	219:246	regeneration	235:246	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration is a promising therapy, but it remains challenging for controlling dose and duration of release.
34128589	5	31	theme	triple-network	875:888	arg1	hydrogels					890:898	3D-printed triple-network hydrogels	864:898	3D-printed triple-network hydrogels for osteogenic stimulation	864:925	This study assesses the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant.
34128589	8	32	theme	triple-polymer-network	1370:1391	arg1	hydrogel					1393:1400	the triple-polymer-network hydrogel	1366:1400	the triple-polymer-network hydrogel	1366:1400	The SMV release from the triple-polymer-network hydrogel has continued for 17 weeks of observation.
34128589	3	33	theme	sustained	575:583	arg1	release					585:591	their sustained release	569:591	their sustained release over several months for long-term regeneration	569:638	Secure loading of hydrophobic drugs by physical interactions is particularly difficult to establish in hydrophilic polymer matrices, and their sustained release over several months for long-term regeneration has rarely been reported.
34128589	2	34	theme	osteogenic	408:417	arg1	stimulation					419:429	osteogenic stimulation	408:429	osteogenic stimulation	408:429	Simvastatin (SMV), a hydrophobic drug, has shown potential for osteogenic stimulation.
34128589	9	35	theme	various	1481:1487	arg1	formulations					1489:1500	various formulations	1481:1500	various formulations	1481:1500	Cytocompatibility of hydrogels with various formulations is confirmed.
34128589	3	36	theme	hydrophobic	450:460	arg1	drugs					462:466	hydrophobic drugs	450:466	hydrophobic drugs	450:466	Secure loading of hydrophobic drugs by physical interactions is particularly difficult to establish in hydrophilic polymer matrices, and their sustained release over several months for long-term regeneration has rarely been reported.
34128589	5	37	theme	mechanical	951:960	arg1	properties					977:986	their mechanical and biological properties	945:986	their mechanical and biological properties	945:986	This study assesses the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant.
34128589	5	37	theme	mechanical	951:960	arg1	implant					994:1000	an implant	991:1000	an implant	991:1000	This study assesses the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant.
34128589	1	38	theme	bone	230:233	arg1	regeneration					235:246	tissue and bone regeneration	219:246	regeneration	235:246	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration is a promising therapy, but it remains challenging for controlling dose and duration of release.
34128589	0	39	theme	Simvastatin	32:42	arg1	Release					21:27	Long-Term Controlled Release	0:27	Long-Term Controlled Release of Simvastatin from Photoprinted Triple-Networked Hydrogels	0:87	Long-Term Controlled Release of Simvastatin from Photoprinted Triple-Networked Hydrogels Composed of Modified Chitosan and PLA-PEG Micelles.
34128589	6	40	theme	polymeric	1022:1030	arg1	micelles					1032:1039	polymeric micelles	1022:1039	polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA)	1022:1110	SMV is loaded into polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA) and mixed with N-methacryloyl chitosan and PEG dimethacrylate to fabricate hydrogels by photo-cross-linked 3D printing.
34128589	3	41	theme	long-term	617:625	arg1	regeneration					627:638	long-term regeneration	617:638	long-term regeneration	617:638	Secure loading of hydrophobic drugs by physical interactions is particularly difficult to establish in hydrophilic polymer matrices, and their sustained release over several months for long-term regeneration has rarely been reported.
34128589	3	42	theme	drugs	462:466	arg1	loading					439:445	Secure loading	432:445	Secure loading of hydrophobic drugs by physical interactions	432:491	Secure loading of hydrophobic drugs by physical interactions is particularly difficult to establish in hydrophilic polymer matrices, and their sustained release over several months for long-term regeneration has rarely been reported.
34128589	0	43	theme	Triple-Networked	62:77	arg1	Hydrogels					79:87	Photoprinted Triple-Networked Hydrogels	49:87	Photoprinted Triple-Networked Hydrogels	49:87	Long-Term Controlled Release of Simvastatin from Photoprinted Triple-Networked Hydrogels Composed of Modified Chitosan and PLA-PEG Micelles.
34128589	5	44	theme	SMV	847:849	arg1	release					851:857	controlled SMV release	836:857	controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation	836:925	This study assesses the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant.
34128589	0	45	from	Hydrogels	79:87	arg1	Release					21:27	Long-Term Controlled Release	0:27	Long-Term Controlled Release of Simvastatin from Photoprinted Triple-Networked Hydrogels	0:87	Long-Term Controlled Release of Simvastatin from Photoprinted Triple-Networked Hydrogels Composed of Modified Chitosan and PLA-PEG Micelles.
34128589	3	46	theme	several	598:604	arg1	months					606:611	several months	598:611	several months for long-term regeneration	598:638	Secure loading of hydrophobic drugs by physical interactions is particularly difficult to establish in hydrophilic polymer matrices, and their sustained release over several months for long-term regeneration has rarely been reported.
34128589	4	47	theme	sufficient	738:747	arg1	support					749:755	a sufficient support	736:755	a sufficient support	736:755	Additionally, mechanical properties of hydrogels must be improved for a sufficient support while maintaining eventual biodegradability.
34128589	0	48	theme	Photoprinted	49:60	arg1	Hydrogels					79:87	Photoprinted Triple-Networked Hydrogels	49:87	Photoprinted Triple-Networked Hydrogels	49:87	Long-Term Controlled Release of Simvastatin from Photoprinted Triple-Networked Hydrogels Composed of Modified Chitosan and PLA-PEG Micelles.
34128589	7	49	theme	significant	1293:1303	arg1	dependance					1305:1314	significant dependance	1293:1314	significant dependance	1293:1314	The hydrogel properties and drug release profiles have shown significant dependance on the polymer compositions.
34128589	5	50	from	hydrogels	890:898	arg1	effect					826:831	the effect	822:831	the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation	822:925	This study assesses the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant.
34128589	5	50	from	hydrogels	890:898	arg1	release					851:857	controlled SMV release	836:857	controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation	836:925	This study assesses the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant.
34128589	1	51	theme	Local	141:145	arg1	delivery					147:154	Local delivery	141:154	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration	141:246	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration is a promising therapy, but it remains challenging for controlling dose and duration of release.
34128589	1	51	theme	Local	141:145	arg1	therapy					263:269	a promising therapy	251:269	a promising therapy	251:269	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration is a promising therapy, but it remains challenging for controlling dose and duration of release.
34128589	1	52	theme	release	336:342	arg1	duration					324:331	duration	324:331	duration	324:331	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration is a promising therapy, but it remains challenging for controlling dose and duration of release.
34128589	1	52	theme	release	336:342	arg1	dose					315:318	dose	315:318	dose	315:318	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration is a promising therapy, but it remains challenging for controlling dose and duration of release.
34128589	1	53	theme	active	159:164	arg1	agents					166:171	active agents	159:171	active agents	159:171	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration is a promising therapy, but it remains challenging for controlling dose and duration of release.
34128589	7	54	theme	hydrogel	1236:1243	arg1	properties					1245:1254	The hydrogel properties	1232:1254	The hydrogel properties	1232:1254	The hydrogel properties and drug release profiles have shown significant dependance on the polymer compositions.
34128589	6	55	theme	3D	1219:1220	arg1	printing					1222:1229	photo-cross-linked 3D printing	1200:1229	photo-cross-linked 3D printing	1200:1229	SMV is loaded into polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA) and mixed with N-methacryloyl chitosan and PEG dimethacrylate to fabricate hydrogels by photo-cross-linked 3D printing.
34128589	6	56	theme	photo-cross-linked	1200:1217	arg1	printing					1222:1229	photo-cross-linked 3D printing	1200:1229	photo-cross-linked 3D printing	1200:1229	SMV is loaded into polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA) and mixed with N-methacryloyl chitosan and PEG dimethacrylate to fabricate hydrogels by photo-cross-linked 3D printing.
34128589	8	57	theme	observation	1432:1442	arg1	weeks					1423:1427	17 weeks	1420:1427	17 weeks of observation	1420:1442	The SMV release from the triple-polymer-network hydrogel has continued for 17 weeks of observation.
34128589	9	58	theme	hydrogels	1466:1474	arg1	Cytocompatibility					1445:1461	Cytocompatibility	1445:1461	Cytocompatibility of hydrogels with various formulations	1445:1500	Cytocompatibility of hydrogels with various formulations is confirmed.
34128589	3	59	theme	hydrophilic	535:545	arg1	matrices					555:562	hydrophilic polymer matrices	535:562	hydrophilic polymer matrices	535:562	Secure loading of hydrophobic drugs by physical interactions is particularly difficult to establish in hydrophilic polymer matrices, and their sustained release over several months for long-term regeneration has rarely been reported.
34128589	6	60	dep	polylactide/poly	1044:1059	arg1	glycol					1070:1075	ethylene glycol	1061:1075	ethylene glycol	1061:1075	SMV is loaded into polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA) and mixed with N-methacryloyl chitosan and PEG dimethacrylate to fabricate hydrogels by photo-cross-linked 3D printing.
34128589	6	61	theme	N-methacryloyl	1127:1140	arg1	chitosan					1142:1149	chitosan	1142:1149	chitosan	1142:1149	SMV is loaded into polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA) and mixed with N-methacryloyl chitosan and PEG dimethacrylate to fabricate hydrogels by photo-cross-linked 3D printing.
34128589	2	62	theme	hydrophobic	366:376	arg1	drug					378:381	a hydrophobic drug	364:381	a hydrophobic drug	364:381	Simvastatin (SMV), a hydrophobic drug, has shown potential for osteogenic stimulation.
34128589	2	62	theme	hydrophobic	366:376	arg1	Simvastatin					345:355	Simvastatin	345:355	Simvastatin (SMV)	345:361	Simvastatin (SMV), a hydrophobic drug, has shown potential for osteogenic stimulation.
34128589	4	63	theme	mechanical	680:689	arg1	properties					691:700	mechanical properties	680:700	mechanical properties of hydrogels	680:713	Additionally, mechanical properties of hydrogels must be improved for a sufficient support while maintaining eventual biodegradability.
34128589	1	64	theme	promising	253:261	arg1	delivery					147:154	Local delivery	141:154	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration	141:246	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration is a promising therapy, but it remains challenging for controlling dose and duration of release.
34128589	1	64	theme	promising	253:261	arg1	therapy					263:269	a promising therapy	251:269	a promising therapy	251:269	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration is a promising therapy, but it remains challenging for controlling dose and duration of release.
34128589	5	65	theme	controlled	836:845	arg1	release					851:857	controlled SMV release	836:857	controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation	836:925	This study assesses the effect of controlled SMV release from 3D-printed triple-network hydrogels for osteogenic stimulation and characterizes their mechanical and biological properties as an implant.
34128589	6	66	link	photo-cross-linked	1200:1217	arg1	printing					1222:1229	photo-cross-linked 3D printing	1200:1229	photo-cross-linked 3D printing	1200:1229	SMV is loaded into polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA) and mixed with N-methacryloyl chitosan and PEG dimethacrylate to fabricate hydrogels by photo-cross-linked 3D printing.
34128589	7	67	theme	release	1265:1271	arg1	profiles					1273:1280	drug release profiles	1260:1280	drug release profiles	1260:1280	The hydrogel properties and drug release profiles have shown significant dependance on the polymer compositions.
34128589	1	68	theme	agents	166:171	arg1	delivery					147:154	Local delivery	141:154	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration	141:246	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration is a promising therapy, but it remains challenging for controlling dose and duration of release.
34128589	1	68	theme	agents	166:171	arg1	therapy					263:269	a promising therapy	251:269	a promising therapy	251:269	Local delivery of active agents using injectable or implantable hydrogels for tissue and bone regeneration is a promising therapy, but it remains challenging for controlling dose and duration of release.
34128589	6	69	theme	copolymers	1087:1096	arg1	micelles					1032:1039	polymeric micelles	1022:1039	polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA)	1022:1110	SMV is loaded into polymeric micelles of polylactide/poly(ethylene glycol) triblock copolymers (PLA-PEG-PLA) and mixed with N-methacryloyl chitosan and PEG dimethacrylate to fabricate hydrogels by photo-cross-linked 3D printing.
34076655	0	0	theme	supramolecular	88:101	arg1	complexes					115:123	supramolecular coiled coil complexes	88:123	supramolecular coiled coil complexes	88:123	User-defined, temporal presentation of bioactive molecules on hydrogel substrates using supramolecular coiled coil complexes.
34076655	5	1	theme	association	847:857	arg1	A-peptide					868:876	A-peptide	868:876	A-peptide	868:876	The complementary association peptide (A-peptide), containing the bioactive domain, forms a heterodimeric coiled coil complex with the T-peptide.
34076655	5	1	theme	association	847:857	arg1	peptide					859:865	The complementary association peptide	829:865	The complementary association peptide (A-peptide)	829:877	The complementary association peptide (A-peptide), containing the bioactive domain, forms a heterodimeric coiled coil complex with the T-peptide.
34076655	6	2	from	scaffold	1174:1181	arg1	A-peptide					1122:1130	the A-peptide	1118:1130	the A-peptide	1118:1130	Addition of a disruptor peptide (D-peptide) engineered specifically to target the A-peptide outcompetes the T-peptide for binding, and removes the A-peptide and the attached bioactive motif from the scaffold.
34076655	6	2	from	scaffold	1174:1181	arg1	motif					1159:1163	the attached bioactive motif	1136:1163	the attached bioactive motif	1136:1163	Addition of a disruptor peptide (D-peptide) engineered specifically to target the A-peptide outcompetes the T-peptide for binding, and removes the A-peptide and the attached bioactive motif from the scaffold.
34076655	8	3	theme	NIH	1377:1379	arg1	fibroblasts					1385:1395	NIH 3T3 fibroblasts	1377:1395	NIH 3T3 fibroblasts seeded on hyaluronic acid hydrogels and polyethylene glycol-based fibrous substrates supramolecularly functionalized with an RGD motif	1377:1530	NIH 3T3 fibroblasts seeded on hyaluronic acid hydrogels and polyethylene glycol-based fibrous substrates supramolecularly functionalized with an RGD motif demonstrated significant cell spreading over their nonfunctionalized counterparts.
34076655	1	4	theme	strive	285:290	arg1	researchers					273:283	researchers	273:283	researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro	273:357	The ability to spatiotemporally control the presentation of relevant biomolecules in synthetic culture systems has gained significant attention as researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro.
34076655	1	4	theme	strive	285:290	arg1	attention					260:268	significant attention	248:268	significant attention	248:268	The ability to spatiotemporally control the presentation of relevant biomolecules in synthetic culture systems has gained significant attention as researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro.
34076655	6	5	theme	disruptor	989:997	arg1	D-peptide					1008:1016	D-peptide	1008:1016	D-peptide	1008:1016	Addition of a disruptor peptide (D-peptide) engineered specifically to target the A-peptide outcompetes the T-peptide for binding, and removes the A-peptide and the attached bioactive motif from the scaffold.
34076655	6	5	theme	disruptor	989:997	arg1	peptide					999:1005	a disruptor peptide	987:1005	a disruptor peptide (D-peptide) engineered specifically to target the A-peptide	987:1065	Addition of a disruptor peptide (D-peptide) engineered specifically to target the A-peptide outcompetes the T-peptide for binding, and removes the A-peptide and the attached bioactive motif from the scaffold.
34076655	1	6	from	presentation	170:181	arg1	systems					229:235	synthetic culture systems	211:235	synthetic culture systems	211:235	The ability to spatiotemporally control the presentation of relevant biomolecules in synthetic culture systems has gained significant attention as researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro.
34076655	8	7	theme	nonfunctionalized	1583:1599	arg1	counterparts					1601:1612	their nonfunctionalized counterparts	1577:1612	their nonfunctionalized counterparts	1577:1612	NIH 3T3 fibroblasts seeded on hyaluronic acid hydrogels and polyethylene glycol-based fibrous substrates supramolecularly functionalized with an RGD motif demonstrated significant cell spreading over their nonfunctionalized counterparts.
34076655	10	8	from	presentation	1854:1865	arg1	systems					1904:1910	engineered culture systems	1885:1910	engineered culture systems	1885:1910	Taken together, this platform enables facile user-defined incorporation and removal of biomolecules in a repeatable process for controlled presentation of bioactivity in engineered culture systems.
34076655	0	9	theme	coil	110:113	arg1	complexes					115:123	supramolecular coiled coil complexes	88:123	supramolecular coiled coil complexes	88:123	User-defined, temporal presentation of bioactive molecules on hydrogel substrates using supramolecular coiled coil complexes.
34076655	3	10	theme	hydrogel-based	569:582	arg1	substrates					584:593	hydrogel-based substrates	569:593	hydrogel-based substrates	569:593	Here, we reversibly conjugate bioactive molecules to hydrogel-based substrates through supramolecular coiled coil complexes that form between complementary peptides.
34076655	0	11	theme	coiled	103:108	arg1	complexes					115:123	supramolecular coiled coil complexes	88:123	supramolecular coiled coil complexes	88:123	User-defined, temporal presentation of bioactive molecules on hydrogel substrates using supramolecular coiled coil complexes.
34076655	8	12	theme	acid	1418:1421	arg1	hydrogels					1423:1431	hyaluronic acid hydrogels	1407:1431	hyaluronic acid hydrogels	1407:1431	NIH 3T3 fibroblasts seeded on hyaluronic acid hydrogels and polyethylene glycol-based fibrous substrates supramolecularly functionalized with an RGD motif demonstrated significant cell spreading over their nonfunctionalized counterparts.
34076655	5	13	theme	coiled	935:940	arg1	complex					947:953	a heterodimeric coiled coil complex	919:953	a heterodimeric coiled coil complex with the T-peptide	919:972	The complementary association peptide (A-peptide), containing the bioactive domain, forms a heterodimeric coiled coil complex with the T-peptide.
34076655	7	14	theme	hydrogel	1278:1285	arg1	systems					1287:1293	hydrogel systems	1278:1293	hydrogel systems in a repeatable process that can be extended to adhesive motifs for cell culture	1278:1374	We use this platform to demonstrate spatiotemporal control of biomolecule presentation within hydrogel systems in a repeatable process that can be extended to adhesive motifs for cell culture.
34076655	7	15	theme	cell	1363:1366	arg1	culture					1368:1374	cell culture	1363:1374	cell culture	1363:1374	We use this platform to demonstrate spatiotemporal control of biomolecule presentation within hydrogel systems in a repeatable process that can be extended to adhesive motifs for cell culture.
34076655	7	16	theme	biomolecule	1246:1256	arg1	presentation					1258:1269	biomolecule presentation	1246:1269	biomolecule presentation	1246:1269	We use this platform to demonstrate spatiotemporal control of biomolecule presentation within hydrogel systems in a repeatable process that can be extended to adhesive motifs for cell culture.
34076655	4	17	theme	click	813:817	arg1	reaction					819:826	a spatially-controlled photomediated click reaction	776:826	a spatially-controlled photomediated click reaction	776:826	Our system employs a thiolated peptide for tethering to hydrogel surfaces (T-peptide) through a spatially-controlled photomediated click reaction.
34076655	8	18	theme	glycol-based	1450:1461	arg1	substrates					1471:1480	polyethylene glycol-based fibrous substrates	1437:1480	polyethylene glycol-based fibrous substrates	1437:1480	NIH 3T3 fibroblasts seeded on hyaluronic acid hydrogels and polyethylene glycol-based fibrous substrates supramolecularly functionalized with an RGD motif demonstrated significant cell spreading over their nonfunctionalized counterparts.
34076655	10	19	theme	biomolecules	1802:1813	arg1	removal					1791:1797	removal	1791:1797	removal of biomolecules	1791:1813	Taken together, this platform enables facile user-defined incorporation and removal of biomolecules in a repeatable process for controlled presentation of bioactivity in engineered culture systems.
34076655	10	19	theme	biomolecules	1802:1813	arg1	incorporation					1773:1785	facile user-defined incorporation	1753:1785	facile user-defined incorporation	1753:1785	Taken together, this platform enables facile user-defined incorporation and removal of biomolecules in a repeatable process for controlled presentation of bioactivity in engineered culture systems.
34076655	1	20	theme	relevant	186:193	arg1	biomolecules					195:206	relevant biomolecules	186:206	relevant biomolecules	186:206	The ability to spatiotemporally control the presentation of relevant biomolecules in synthetic culture systems has gained significant attention as researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro.
34076655	10	21	theme	facile	1753:1758	arg1	incorporation					1773:1785	facile user-defined incorporation	1753:1785	facile user-defined incorporation	1753:1785	Taken together, this platform enables facile user-defined incorporation and removal of biomolecules in a repeatable process for controlled presentation of bioactivity in engineered culture systems.
34076655	10	22	theme	repeatable	1820:1829	arg1	process					1831:1837	a repeatable process	1818:1837	a repeatable process for controlled presentation of bioactivity in engineered culture systems	1818:1910	Taken together, this platform enables facile user-defined incorporation and removal of biomolecules in a repeatable process for controlled presentation of bioactivity in engineered culture systems.
34076655	7	23	theme	spatiotemporal	1220:1233	arg1	control					1235:1241	spatiotemporal control	1220:1241	spatiotemporal control of biomolecule presentation within hydrogel systems in a repeatable process that can be extended to adhesive motifs for cell culture	1220:1374	We use this platform to demonstrate spatiotemporal control of biomolecule presentation within hydrogel systems in a repeatable process that can be extended to adhesive motifs for cell culture.
34076655	8	24	theme	polyethylene	1437:1448	arg1	substrates					1471:1480	polyethylene glycol-based fibrous substrates	1437:1480	polyethylene glycol-based fibrous substrates	1437:1480	NIH 3T3 fibroblasts seeded on hyaluronic acid hydrogels and polyethylene glycol-based fibrous substrates supramolecularly functionalized with an RGD motif demonstrated significant cell spreading over their nonfunctionalized counterparts.
34076655	1	25	theme	biomolecules	195:206	arg1	presentation					170:181	the presentation	166:181	the presentation of relevant biomolecules in synthetic culture systems	166:235	The ability to spatiotemporally control the presentation of relevant biomolecules in synthetic culture systems has gained significant attention as researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro.
34076655	2	26	theme	user-defined	468:479	arg1	control					481:487	user-defined control	468:487	user-defined control of bioactivity	468:502	With the biochemical composition of the ECM constantly in flux, the development of platforms that allow for user-defined control of bioactivity is desired.
34076655	2	27	from	composition	381:391	arg1	flux					418:421	flux	418:421	flux	418:421	With the biochemical composition of the ECM constantly in flux, the development of platforms that allow for user-defined control of bioactivity is desired.
34076655	3	28	theme	coiled	618:623	arg1	complexes					630:638	supramolecular coiled coil complexes	603:638	supramolecular coiled coil complexes that form between complementary peptides	603:679	Here, we reversibly conjugate bioactive molecules to hydrogel-based substrates through supramolecular coiled coil complexes that form between complementary peptides.
34076655	7	29	theme	presentation	1258:1269	arg1	control					1235:1241	spatiotemporal control	1220:1241	spatiotemporal control of biomolecule presentation within hydrogel systems in a repeatable process that can be extended to adhesive motifs for cell culture	1220:1374	We use this platform to demonstrate spatiotemporal control of biomolecule presentation within hydrogel systems in a repeatable process that can be extended to adhesive motifs for cell culture.
34076655	6	30	theme	attached	1140:1147	arg1	motif					1159:1163	the attached bioactive motif	1136:1163	the attached bioactive motif	1136:1163	Addition of a disruptor peptide (D-peptide) engineered specifically to target the A-peptide outcompetes the T-peptide for binding, and removes the A-peptide and the attached bioactive motif from the scaffold.
34076655	0	31	theme	User-defined	0:11	arg1	presentation					23:34	User-defined, temporal presentation	0:34	User-defined, temporal presentation of bioactive molecules on hydrogel substrates using supramolecular coiled coil complexes.	0:124	User-defined, temporal presentation of bioactive molecules on hydrogel substrates using supramolecular coiled coil complexes.
34076655	1	32	theme	endogenous	312:321	arg1	matrix					337:342	the endogenous extracellular matrix	308:342	the endogenous extracellular matrix (ECM)	308:348	The ability to spatiotemporally control the presentation of relevant biomolecules in synthetic culture systems has gained significant attention as researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro.
34076655	1	32	theme	endogenous	312:321	arg1	ECM					345:347	ECM	345:347	ECM	345:347	The ability to spatiotemporally control the presentation of relevant biomolecules in synthetic culture systems has gained significant attention as researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro.
34076655	10	33	theme	controlled	1843:1852	arg1	presentation					1854:1865	controlled presentation	1843:1865	controlled presentation of bioactivity in engineered culture systems	1843:1910	Taken together, this platform enables facile user-defined incorporation and removal of biomolecules in a repeatable process for controlled presentation of bioactivity in engineered culture systems.
34076655	3	34	theme	coil	625:628	arg1	complexes					630:638	supramolecular coiled coil complexes	603:638	supramolecular coiled coil complexes that form between complementary peptides	603:679	Here, we reversibly conjugate bioactive molecules to hydrogel-based substrates through supramolecular coiled coil complexes that form between complementary peptides.
34076655	1	35	theme	synthetic	211:219	arg1	systems					229:235	synthetic culture systems	211:235	synthetic culture systems	211:235	The ability to spatiotemporally control the presentation of relevant biomolecules in synthetic culture systems has gained significant attention as researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro.
34076655	5	36	theme	bioactive	895:903	arg1	domain					905:910	the bioactive domain	891:910	the bioactive domain	891:910	The complementary association peptide (A-peptide), containing the bioactive domain, forms a heterodimeric coiled coil complex with the T-peptide.
34076655	1	37	theme	extracellular	323:335	arg1	matrix					337:342	the endogenous extracellular matrix	308:342	the endogenous extracellular matrix (ECM)	308:348	The ability to spatiotemporally control the presentation of relevant biomolecules in synthetic culture systems has gained significant attention as researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro.
34076655	1	37	theme	extracellular	323:335	arg1	ECM					345:347	ECM	345:347	ECM	345:347	The ability to spatiotemporally control the presentation of relevant biomolecules in synthetic culture systems has gained significant attention as researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro.
34076655	8	38	theme	3T3	1381:1383	arg1	fibroblasts					1385:1395	NIH 3T3 fibroblasts	1377:1395	NIH 3T3 fibroblasts seeded on hyaluronic acid hydrogels and polyethylene glycol-based fibrous substrates supramolecularly functionalized with an RGD motif	1377:1530	NIH 3T3 fibroblasts seeded on hyaluronic acid hydrogels and polyethylene glycol-based fibrous substrates supramolecularly functionalized with an RGD motif demonstrated significant cell spreading over their nonfunctionalized counterparts.
34076655	8	39	theme	RGD	1522:1524	arg1	motif					1526:1530	an RGD motif	1519:1530	an RGD motif	1519:1530	NIH 3T3 fibroblasts seeded on hyaluronic acid hydrogels and polyethylene glycol-based fibrous substrates supramolecularly functionalized with an RGD motif demonstrated significant cell spreading over their nonfunctionalized counterparts.
34076655	8	40	theme	hyaluronic	1407:1416	arg1	acid					1418:1421	hyaluronic acid	1407:1421	hyaluronic acid hydrogels	1407:1431	NIH 3T3 fibroblasts seeded on hyaluronic acid hydrogels and polyethylene glycol-based fibrous substrates supramolecularly functionalized with an RGD motif demonstrated significant cell spreading over their nonfunctionalized counterparts.
34076655	6	41	theme	bioactive	1149:1157	arg1	motif					1159:1163	the attached bioactive motif	1136:1163	the attached bioactive motif	1136:1163	Addition of a disruptor peptide (D-peptide) engineered specifically to target the A-peptide outcompetes the T-peptide for binding, and removes the A-peptide and the attached bioactive motif from the scaffold.
34076655	2	42	theme	platforms	443:451	arg1	development					428:438	the development	424:438	the development of platforms that allow for user-defined control of bioactivity	424:502	With the biochemical composition of the ECM constantly in flux, the development of platforms that allow for user-defined control of bioactivity is desired.
34076655	4	43	theme	photomediated	799:811	arg1	reaction					819:826	a spatially-controlled photomediated click reaction	776:826	a spatially-controlled photomediated click reaction	776:826	Our system employs a thiolated peptide for tethering to hydrogel surfaces (T-peptide) through a spatially-controlled photomediated click reaction.
34076655	3	44	theme	supramolecular	603:616	arg1	complexes					630:638	supramolecular coiled coil complexes	603:638	supramolecular coiled coil complexes that form between complementary peptides	603:679	Here, we reversibly conjugate bioactive molecules to hydrogel-based substrates through supramolecular coiled coil complexes that form between complementary peptides.
34076655	10	45	theme	engineered	1885:1894	arg1	systems					1904:1910	engineered culture systems	1885:1910	engineered culture systems	1885:1910	Taken together, this platform enables facile user-defined incorporation and removal of biomolecules in a repeatable process for controlled presentation of bioactivity in engineered culture systems.
34076655	0	46	theme	bioactive	39:47	arg1	molecules					49:57	bioactive molecules	39:57	bioactive molecules	39:57	User-defined, temporal presentation of bioactive molecules on hydrogel substrates using supramolecular coiled coil complexes.
34076655	7	47	from	systems	1287:1293	arg1	process					1311:1317	a repeatable process	1298:1317	a repeatable process that can be extended to adhesive motifs for cell culture	1298:1374	We use this platform to demonstrate spatiotemporal control of biomolecule presentation within hydrogel systems in a repeatable process that can be extended to adhesive motifs for cell culture.
34076655	4	48	theme	thiolated	703:711	arg1	peptide					713:719	a thiolated peptide	701:719	a thiolated peptide for tethering to hydrogel surfaces (T-peptide)	701:766	Our system employs a thiolated peptide for tethering to hydrogel surfaces (T-peptide) through a spatially-controlled photomediated click reaction.
34076655	2	49	theme	bioactivity	492:502	arg1	control					481:487	user-defined control	468:487	user-defined control of bioactivity	468:502	With the biochemical composition of the ECM constantly in flux, the development of platforms that allow for user-defined control of bioactivity is desired.
34076655	5	50	theme	heterodimeric	921:933	arg1	complex					947:953	a heterodimeric coiled coil complex	919:953	a heterodimeric coiled coil complex with the T-peptide	919:972	The complementary association peptide (A-peptide), containing the bioactive domain, forms a heterodimeric coiled coil complex with the T-peptide.
34076655	10	51	theme	user-defined	1760:1771	arg1	incorporation					1773:1785	facile user-defined incorporation	1753:1785	facile user-defined incorporation	1753:1785	Taken together, this platform enables facile user-defined incorporation and removal of biomolecules in a repeatable process for controlled presentation of bioactivity in engineered culture systems.
34076655	10	52	theme	culture	1896:1902	arg1	systems					1904:1910	engineered culture systems	1885:1910	engineered culture systems	1885:1910	Taken together, this platform enables facile user-defined incorporation and removal of biomolecules in a repeatable process for controlled presentation of bioactivity in engineered culture systems.
34076655	5	53	with	complex	947:953	arg1	T-peptide					964:972	the T-peptide	960:972	the T-peptide	960:972	The complementary association peptide (A-peptide), containing the bioactive domain, forms a heterodimeric coiled coil complex with the T-peptide.
34076655	5	54	contain	containing	880:889	arg2	domain					905:910	the bioactive domain	891:910	the bioactive domain	891:910	The complementary association peptide (A-peptide), containing the bioactive domain, forms a heterodimeric coiled coil complex with the T-peptide.
34076655	5	54	contain	containing	880:889	arg1	A-peptide					868:876	A-peptide	868:876	A-peptide	868:876	The complementary association peptide (A-peptide), containing the bioactive domain, forms a heterodimeric coiled coil complex with the T-peptide.
34076655	5	54	contain	containing	880:889	arg1	peptide					859:865	The complementary association peptide	829:865	The complementary association peptide (A-peptide)	829:877	The complementary association peptide (A-peptide), containing the bioactive domain, forms a heterodimeric coiled coil complex with the T-peptide.
34076655	10	55	theme	bioactivity	1870:1880	arg1	presentation					1854:1865	controlled presentation	1843:1865	controlled presentation of bioactivity in engineered culture systems	1843:1910	Taken together, this platform enables facile user-defined incorporation and removal of biomolecules in a repeatable process for controlled presentation of bioactivity in engineered culture systems.
34076655	8	56	theme	fibrous	1463:1469	arg1	substrates					1471:1480	polyethylene glycol-based fibrous substrates	1437:1480	polyethylene glycol-based fibrous substrates	1437:1480	NIH 3T3 fibroblasts seeded on hyaluronic acid hydrogels and polyethylene glycol-based fibrous substrates supramolecularly functionalized with an RGD motif demonstrated significant cell spreading over their nonfunctionalized counterparts.
34076655	2	57	theme	biochemical	369:379	arg1	composition					381:391	the biochemical composition	365:391	the biochemical composition of the ECM constantly in flux	365:421	With the biochemical composition of the ECM constantly in flux, the development of platforms that allow for user-defined control of bioactivity is desired.
34076655	0	58	theme	molecules	49:57	arg1	presentation					23:34	User-defined, temporal presentation	0:34	User-defined, temporal presentation of bioactive molecules on hydrogel substrates using supramolecular coiled coil complexes.	0:124	User-defined, temporal presentation of bioactive molecules on hydrogel substrates using supramolecular coiled coil complexes.
34076655	6	59	theme	peptide	999:1005	arg1	Addition					975:982	Addition	975:982	Addition of a disruptor peptide (D-peptide) engineered specifically to target the A-peptide	975:1065	Addition of a disruptor peptide (D-peptide) engineered specifically to target the A-peptide outcompetes the T-peptide for binding, and removes the A-peptide and the attached bioactive motif from the scaffold.
34076655	8	60	theme	cell	1557:1560	arg1	spreading					1562:1570	significant cell spreading	1545:1570	significant cell spreading	1545:1570	NIH 3T3 fibroblasts seeded on hyaluronic acid hydrogels and polyethylene glycol-based fibrous substrates supramolecularly functionalized with an RGD motif demonstrated significant cell spreading over their nonfunctionalized counterparts.
34076655	9	61	theme	RGD	1640:1642	arg1	motif					1644:1648	the RGD motif	1636:1648	the RGD motif	1636:1648	Upon displacement of the RGD motif, fibroblasts occupied less area and clustured on the substrates.
34076655	7	62	theme	adhesive	1343:1350	arg1	motifs					1352:1357	adhesive motifs	1343:1357	adhesive motifs for cell culture	1343:1374	We use this platform to demonstrate spatiotemporal control of biomolecule presentation within hydrogel systems in a repeatable process that can be extended to adhesive motifs for cell culture.
34076655	8	63	theme	significant	1545:1555	arg1	spreading					1562:1570	significant cell spreading	1545:1570	significant cell spreading	1545:1570	NIH 3T3 fibroblasts seeded on hyaluronic acid hydrogels and polyethylene glycol-based fibrous substrates supramolecularly functionalized with an RGD motif demonstrated significant cell spreading over their nonfunctionalized counterparts.
34076655	5	64	theme	complementary	833:845	arg1	A-peptide					868:876	A-peptide	868:876	A-peptide	868:876	The complementary association peptide (A-peptide), containing the bioactive domain, forms a heterodimeric coiled coil complex with the T-peptide.
34076655	5	64	theme	complementary	833:845	arg1	peptide					859:865	The complementary association peptide	829:865	The complementary association peptide (A-peptide)	829:877	The complementary association peptide (A-peptide), containing the bioactive domain, forms a heterodimeric coiled coil complex with the T-peptide.
34076655	4	65	theme	spatially-controlled	778:797	arg1	reaction					819:826	a spatially-controlled photomediated click reaction	776:826	a spatially-controlled photomediated click reaction	776:826	Our system employs a thiolated peptide for tethering to hydrogel surfaces (T-peptide) through a spatially-controlled photomediated click reaction.
34076655	1	66	theme	significant	248:258	arg1	researchers					273:283	researchers	273:283	researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro	273:357	The ability to spatiotemporally control the presentation of relevant biomolecules in synthetic culture systems has gained significant attention as researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro.
34076655	1	66	theme	significant	248:258	arg1	attention					260:268	significant attention	248:268	significant attention	248:268	The ability to spatiotemporally control the presentation of relevant biomolecules in synthetic culture systems has gained significant attention as researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro.
34076655	7	67	theme	repeatable	1300:1309	arg1	process					1311:1317	a repeatable process	1298:1317	a repeatable process that can be extended to adhesive motifs for cell culture	1298:1374	We use this platform to demonstrate spatiotemporal control of biomolecule presentation within hydrogel systems in a repeatable process that can be extended to adhesive motifs for cell culture.
34076655	4	68	theme	hydrogel	738:745	arg1	T-peptide					757:765	T-peptide	757:765	T-peptide	757:765	Our system employs a thiolated peptide for tethering to hydrogel surfaces (T-peptide) through a spatially-controlled photomediated click reaction.
34076655	4	68	theme	hydrogel	738:745	arg1	surfaces					747:754	hydrogel surfaces	738:754	hydrogel surfaces (T-peptide)	738:766	Our system employs a thiolated peptide for tethering to hydrogel surfaces (T-peptide) through a spatially-controlled photomediated click reaction.
34076655	9	69	used	occupied	1663:1670	arg2	fibroblasts					1651:1661	fibroblasts	1651:1661	fibroblasts	1651:1661	Upon displacement of the RGD motif, fibroblasts occupied less area and clustured on the substrates.
34076655	9	70	theme	motif	1644:1648	arg1	displacement					1620:1631	displacement	1620:1631	displacement of the RGD motif	1620:1648	Upon displacement of the RGD motif, fibroblasts occupied less area and clustured on the substrates.
34076655	3	71	theme	complementary	658:670	arg1	peptides					672:679	complementary peptides	658:679	complementary peptides	658:679	Here, we reversibly conjugate bioactive molecules to hydrogel-based substrates through supramolecular coiled coil complexes that form between complementary peptides.
34076655	1	72	theme	culture	221:227	arg1	systems					229:235	synthetic culture systems	211:235	synthetic culture systems	211:235	The ability to spatiotemporally control the presentation of relevant biomolecules in synthetic culture systems has gained significant attention as researchers strive to recapitulate the endogenous extracellular matrix (ECM) in vitro.
34076655	2	73	theme	ECM	400:402	arg1	composition					381:391	the biochemical composition	365:391	the biochemical composition of the ECM constantly in flux	365:421	With the biochemical composition of the ECM constantly in flux, the development of platforms that allow for user-defined control of bioactivity is desired.
34076655	5	74	theme	coil	942:945	arg1	complex					947:953	a heterodimeric coiled coil complex	919:953	a heterodimeric coiled coil complex with the T-peptide	919:972	The complementary association peptide (A-peptide), containing the bioactive domain, forms a heterodimeric coiled coil complex with the T-peptide.
34076655	0	75	theme	hydrogel	62:69	arg1	substrates					71:80	hydrogel substrates	62:80	hydrogel substrates using supramolecular coiled coil complexes	62:123	User-defined, temporal presentation of bioactive molecules on hydrogel substrates using supramolecular coiled coil complexes.
34076655	0	76	from	presentation	23:34	arg1	substrates					71:80	hydrogel substrates	62:80	hydrogel substrates using supramolecular coiled coil complexes	62:123	User-defined, temporal presentation of bioactive molecules on hydrogel substrates using supramolecular coiled coil complexes.
34076655	0	77	dep	User-defined	0:11	arg1	temporal					14:21	temporal	14:21	temporal	14:21	User-defined, temporal presentation of bioactive molecules on hydrogel substrates using supramolecular coiled coil complexes.
34076655	3	78	theme	bioactive	546:554	arg1	molecules					556:564	bioactive molecules	546:564	bioactive molecules to hydrogel-based substrates	546:593	Here, we reversibly conjugate bioactive molecules to hydrogel-based substrates through supramolecular coiled coil complexes that form between complementary peptides.
32092426	6	0	theme	12 mg	1228:1232	arg1	15 mg L-1					1178:1186	15 mg L-1	1178:1186	15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time	1178:1281	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	7	1	from	25 °C	1453:1457	arg1	222.72 mg g-1					1487:1499	222.72 mg g-1	1487:1499	222.72 mg g-1	1487:1499	Moreover, the data were efficiently fitted by Langmuir model, and the saturation adsorption capacity (Qmax) at 25 °C for BF was discovered to be 222.72 mg g-1.
32092426	7	1	from	25 °C	1453:1457	arg1	Qmax					1444:1447	Qmax	1444:1447	Qmax	1444:1447	Moreover, the data were efficiently fitted by Langmuir model, and the saturation adsorption capacity (Qmax) at 25 °C for BF was discovered to be 222.72 mg g-1.
32092426	7	1	from	25 °C	1453:1457	arg1	capacity					1434:1441	the saturation adsorption capacity	1408:1441	the saturation adsorption capacity (Qmax) at 25 °C for BF	1408:1464	Moreover, the data were efficiently fitted by Langmuir model, and the saturation adsorption capacity (Qmax) at 25 °C for BF was discovered to be 222.72 mg g-1.
32092426	1	2	theme	activated	270:278	arg1	composite					305:313	activated carbon (ST-Zn-Se-NPs-AC) composite	270:313	activated carbon (ST-Zn-Se-NPs-AC) composite	270:313	In this study, the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite was fabricated, and then it was used for removing Basic Fuchsin (BF) dye from aqueous solution.
32092426	0	3	theme	Fuchsin	86:92	arg1	adsorption					66:75	ultrasound-assisted high performance adsorption	29:75	ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology	29:196	Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology.
32092426	3	4	theme	Central	662:668	arg1	Design					680:685	Central Composite Design	662:685	Central Composite Design (CCD)	662:691	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	4	theme	Central	662:668	arg1	CCD					688:690	CCD	688:690	CCD	688:690	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	6	5	theme	7.0	1223:1225	arg1	concentration					1202:1214	initial BF concentration	1191:1214	initial BF concentration	1191:1214	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	5	theme	7.0	1223:1225	arg1	6 min					1258:1262	6 min	1258:1262	6 min of sonication time	1258:1281	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	5	theme	7.0	1223:1225	arg1	12 mg					1228:1232	12 mg	1228:1232	12 mg of ST-Zn-Se-NPs-AC	1228:1251	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	5	theme	7.0	1223:1225	arg1	pH					1217:1218	pH	1217:1218	pH of 7.0	1217:1225	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	7	6	theme	Langmuir	1388:1395	arg1	model					1397:1401	Langmuir model	1388:1401	Langmuir model	1388:1401	Moreover, the data were efficiently fitted by Langmuir model, and the saturation adsorption capacity (Qmax) at 25 °C for BF was discovered to be 222.72 mg g-1.
32092426	1	7	theme	carbon	280:285	arg1	composite					305:313	activated carbon (ST-Zn-Se-NPs-AC) composite	270:313	activated carbon (ST-Zn-Se-NPs-AC) composite	270:313	In this study, the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite was fabricated, and then it was used for removing Basic Fuchsin (BF) dye from aqueous solution.
32092426	0	8	theme	zinc	111:114	arg1	nanoparticles/AC					125:140	starch-capped zinc selenide nanoparticles/AC	97:140	starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology	97:196	Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology.
32092426	3	9	theme	Composite	670:678	arg1	Design					680:685	Central Composite Design	662:685	Central Composite Design (CCD)	662:691	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	9	theme	Composite	670:678	arg1	CCD					688:690	CCD	688:690	CCD	688:690	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	6	10	theme	predicted	1132:1140	arg1	model					1142:1146	the predicted model	1128:1146	the predicted model	1128:1146	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	11	theme	time	1278:1281	arg1	concentration					1202:1214	initial BF concentration	1191:1214	initial BF concentration	1191:1214	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	11	theme	time	1278:1281	arg1	6 min					1258:1262	6 min	1258:1262	6 min of sonication time	1258:1281	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	11	theme	time	1278:1281	arg1	12 mg					1228:1232	12 mg	1228:1232	12 mg of ST-Zn-Se-NPs-AC	1228:1251	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	11	theme	time	1278:1281	arg1	pH					1217:1218	pH	1217:1218	pH of 7.0	1217:1225	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	0	12	theme	starch-capped	97:109	arg1	nanoparticles/AC					125:140	starch-capped zinc selenide nanoparticles/AC	97:140	starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology	97:196	Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology.
32092426	1	13	theme	Basic	365:369	arg1	Fuchsin					371:377	Basic Fuchsin	365:377	Basic Fuchsin (BF) dye	365:386	In this study, the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite was fabricated, and then it was used for removing Basic Fuchsin (BF) dye from aqueous solution.
32092426	1	13	theme	Basic	365:369	arg1	BF					380:381	BF	380:381	BF	380:381	In this study, the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite was fabricated, and then it was used for removing Basic Fuchsin (BF) dye from aqueous solution.
32092426	6	14	theme	pH	1217:1218	arg1	15 mg L-1					1178:1186	15 mg L-1	1178:1186	15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time	1178:1281	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	3	15	theme	different	540:548	arg1	time					623:626	time	623:626	time of sonication	623:640	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	15	theme	different	540:548	arg1	dosage					598:603	dosage	598:603	dosage of adsorbent	598:616	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	15	theme	different	540:548	arg1	pH					594:595	pH	594:595	pH	594:595	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	15	theme	different	540:548	arg1	concentration					579:591	initial BF concentration	568:591	initial BF concentration	568:591	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	15	theme	different	540:548	arg1	variables					550:558	different variables	540:558	different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication	540:640	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	1	16	theme	ST-Zn-Se-NPs-AC	288:302	arg1	composite					305:313	activated carbon (ST-Zn-Se-NPs-AC) composite	270:313	activated carbon (ST-Zn-Se-NPs-AC) composite	270:313	In this study, the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite was fabricated, and then it was used for removing Basic Fuchsin (BF) dye from aqueous solution.
32092426	1	17	theme	Fuchsin	371:377	arg1	dye					384:386	Basic Fuchsin (BF) dye	365:386	Basic Fuchsin (BF) dye	365:386	In this study, the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite was fabricated, and then it was used for removing Basic Fuchsin (BF) dye from aqueous solution.
32092426	3	18	theme	percentage	515:524	arg1	dependence					526:535	The removal percentage dependence	503:535	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication	503:640	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	0	19	theme	selenide	116:123	arg1	nanoparticles/AC					125:140	starch-capped zinc selenide nanoparticles/AC	97:140	starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology	97:196	Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology.
32092426	6	20	theme	concentration	1202:1214	arg1	15 mg L-1					1178:1186	15 mg L-1	1178:1186	15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time	1178:1281	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	5	21	theme	predicted	950:958	arg1	model					960:964	the predicted model	946:964	the predicted model for predicting of real optimum points	946:1002	A good agreement between the experimental and predicted data was achieved by the predicted model that showed the performance of the predicted model for predicting of real optimum points, and it was successfully employed to remove BF from aqueous media.
32092426	5	22	theme	aqueous	1056:1062	arg1	media					1064:1068	aqueous media	1056:1068	aqueous media	1056:1068	A good agreement between the experimental and predicted data was achieved by the predicted model that showed the performance of the predicted model for predicting of real optimum points, and it was successfully employed to remove BF from aqueous media.
32092426	2	23	theme	UV-Vis	470:475	arg1	techniques					491:500	FE-SEM, UV-Vis, EDS, and XRD techniques	462:500	FE-SEM, UV-Vis, EDS, and XRD techniques	462:500	The ST-Zn-Se-NPs-AC composite was characterized by FE-SEM, UV-Vis, EDS, and XRD techniques.
32092426	2	24	theme	EDS	478:480	arg1	techniques					491:500	FE-SEM, UV-Vis, EDS, and XRD techniques	462:500	FE-SEM, UV-Vis, EDS, and XRD techniques	462:500	The ST-Zn-Se-NPs-AC composite was characterized by FE-SEM, UV-Vis, EDS, and XRD techniques.
32092426	6	25	theme	BF	1199:1200	arg1	concentration					1202:1214	initial BF concentration	1191:1214	initial BF concentration	1191:1214	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	2	26	theme	XRD	487:489	arg1	techniques					491:500	FE-SEM, UV-Vis, EDS, and XRD techniques	462:500	FE-SEM, UV-Vis, EDS, and XRD techniques	462:500	The ST-Zn-Se-NPs-AC composite was characterized by FE-SEM, UV-Vis, EDS, and XRD techniques.
32092426	3	27	theme	Response	699:706	arg1	RSM					729:731	RSM	729:731	RSM	729:731	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	27	theme	Response	699:706	arg1	Methodology					716:726	Response Surface Methodology	699:726	Response Surface Methodology (RSM)	699:732	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	6	28	theme	initial	1191:1197	arg1	concentration					1202:1214	initial BF concentration	1191:1214	initial BF concentration	1191:1214	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	3	29	theme	initial	568:574	arg1	concentration					579:591	initial BF concentration	568:591	initial BF concentration	568:591	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	6	30	dep	conditions	1166:1175	arg1	15 mg L-1					1178:1186	15 mg L-1	1178:1186	15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time	1178:1281	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	31	theme	sonication	1267:1276	arg1	time					1278:1281	sonication time	1267:1281	sonication time	1267:1281	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	5	32	theme	predicted	899:907	arg1	model					909:913	the predicted model	895:913	the predicted model that showed the performance of the predicted model for predicting of real optimum points	895:1002	A good agreement between the experimental and predicted data was achieved by the predicted model that showed the performance of the predicted model for predicting of real optimum points, and it was successfully employed to remove BF from aqueous media.
32092426	5	33	theme	real	984:987	arg1	points					997:1002	real optimum points	984:1002	real optimum points	984:1002	A good agreement between the experimental and predicted data was achieved by the predicted model that showed the performance of the predicted model for predicting of real optimum points, and it was successfully employed to remove BF from aqueous media.
32092426	2	34	theme	ST-Zn-Se-NPs-AC	415:429	arg1	composite					431:439	The ST-Zn-Se-NPs-AC composite	411:439	The ST-Zn-Se-NPs-AC composite	411:439	The ST-Zn-Se-NPs-AC composite was characterized by FE-SEM, UV-Vis, EDS, and XRD techniques.
32092426	6	35	theme	%	1110:1110	arg1	percentage					1091:1100	The maximum removal percentage	1071:1100	The maximum removal percentage of 99.34%	1071:1110	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	3	36	theme	Surface	708:714	arg1	RSM					729:731	RSM	729:731	RSM	729:731	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	36	theme	Surface	708:714	arg1	Methodology					716:726	Response Surface Methodology	699:726	Response Surface Methodology (RSM)	699:732	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	4	37	theme	quadratic	739:747	arg1	model					749:753	The quadratic model	735:753	The quadratic model between the independent and dependent variables	735:801	The quadratic model between the independent and dependent variables was predicted.
32092426	7	38	theme	adsorption	1423:1432	arg1	222.72 mg g-1					1487:1499	222.72 mg g-1	1487:1499	222.72 mg g-1	1487:1499	Moreover, the data were efficiently fitted by Langmuir model, and the saturation adsorption capacity (Qmax) at 25 °C for BF was discovered to be 222.72 mg g-1.
32092426	7	38	theme	adsorption	1423:1432	arg1	Qmax					1444:1447	Qmax	1444:1447	Qmax	1444:1447	Moreover, the data were efficiently fitted by Langmuir model, and the saturation adsorption capacity (Qmax) at 25 °C for BF was discovered to be 222.72 mg g-1.
32092426	7	38	theme	adsorption	1423:1432	arg1	capacity					1434:1441	the saturation adsorption capacity	1408:1441	the saturation adsorption capacity (Qmax) at 25 °C for BF	1408:1464	Moreover, the data were efficiently fitted by Langmuir model, and the saturation adsorption capacity (Qmax) at 25 °C for BF was discovered to be 222.72 mg g-1.
32092426	0	39	theme	high	49:52	arg1	adsorption					66:75	ultrasound-assisted high performance adsorption	29:75	ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology	29:196	Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology.
32092426	6	40	theme	6 min	1258:1262	arg1	15 mg L-1					1178:1186	15 mg L-1	1178:1186	15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time	1178:1281	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	4	41	theme	dependent	783:791	arg1	variables					793:801	the independent and dependent variables	763:801	the independent and dependent variables	763:801	The quadratic model between the independent and dependent variables was predicted.
32092426	1	42	theme	starch-capped	218:230	arg1	nanoparticles					246:258	the starch-capped zinc selenide nanoparticles	214:258	the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite	214:313	In this study, the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite was fabricated, and then it was used for removing Basic Fuchsin (BF) dye from aqueous solution.
32092426	0	43	theme	ultrasound-assisted	29:47	arg1	adsorption					66:75	ultrasound-assisted high performance adsorption	29:75	ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology	29:196	Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology.
32092426	0	44	theme	novel	147:151	arg1	composite					153:161	a novel composite	145:161	a novel composite using response surface methodology	145:196	Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology.
32092426	5	45	theme	optimum	989:995	arg1	points					997:1002	real optimum points	984:1002	real optimum points	984:1002	A good agreement between the experimental and predicted data was achieved by the predicted model that showed the performance of the predicted model for predicting of real optimum points, and it was successfully employed to remove BF from aqueous media.
32092426	1	46	theme	zinc	232:235	arg1	nanoparticles					246:258	the starch-capped zinc selenide nanoparticles	214:258	the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite	214:313	In this study, the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite was fabricated, and then it was used for removing Basic Fuchsin (BF) dye from aqueous solution.
32092426	0	47	theme	adsorption	66:75	arg1	optimization					13:24	optimization	13:24	optimization	13:24	Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology.
32092426	0	47	theme	adsorption	66:75	arg1	Modeling					0:7	Modeling	0:7	Modeling	0:7	Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology.
32092426	7	48	theme	saturation	1412:1421	arg1	222.72 mg g-1					1487:1499	222.72 mg g-1	1487:1499	222.72 mg g-1	1487:1499	Moreover, the data were efficiently fitted by Langmuir model, and the saturation adsorption capacity (Qmax) at 25 °C for BF was discovered to be 222.72 mg g-1.
32092426	7	48	theme	saturation	1412:1421	arg1	Qmax					1444:1447	Qmax	1444:1447	Qmax	1444:1447	Moreover, the data were efficiently fitted by Langmuir model, and the saturation adsorption capacity (Qmax) at 25 °C for BF was discovered to be 222.72 mg g-1.
32092426	7	48	theme	saturation	1412:1421	arg1	capacity					1434:1441	the saturation adsorption capacity	1408:1441	the saturation adsorption capacity (Qmax) at 25 °C for BF	1408:1464	Moreover, the data were efficiently fitted by Langmuir model, and the saturation adsorption capacity (Qmax) at 25 °C for BF was discovered to be 222.72 mg g-1.
32092426	0	49	theme	response	169:176	arg1	methodology					186:196	response surface methodology	169:196	response surface methodology	169:196	Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology.
32092426	1	50	theme	aqueous	393:399	arg1	solution					401:408	aqueous solution	393:408	aqueous solution	393:408	In this study, the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite was fabricated, and then it was used for removing Basic Fuchsin (BF) dye from aqueous solution.
32092426	3	51	theme	BF	576:577	arg1	concentration					579:591	initial BF concentration	568:591	initial BF concentration	568:591	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	0	52	theme	performance	54:64	arg1	adsorption					66:75	ultrasound-assisted high performance adsorption	29:75	ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology	29:196	Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology.
32092426	1	53	used	used	347:350	arg2	it					340:341	it	340:341	it	340:341	In this study, the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite was fabricated, and then it was used for removing Basic Fuchsin (BF) dye from aqueous solution.
32092426	6	54	theme	ST-Zn-Se-NPs-AC	1237:1251	arg1	concentration					1202:1214	initial BF concentration	1191:1214	initial BF concentration	1191:1214	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	54	theme	ST-Zn-Se-NPs-AC	1237:1251	arg1	6 min					1258:1262	6 min	1258:1262	6 min of sonication time	1258:1281	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	54	theme	ST-Zn-Se-NPs-AC	1237:1251	arg1	12 mg					1228:1232	12 mg	1228:1232	12 mg of ST-Zn-Se-NPs-AC	1228:1251	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	54	theme	ST-Zn-Se-NPs-AC	1237:1251	arg1	pH					1217:1218	pH	1217:1218	pH of 7.0	1217:1225	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	2	55	theme	FE-SEM	462:467	arg1	techniques					491:500	FE-SEM, UV-Vis, EDS, and XRD techniques	462:500	FE-SEM, UV-Vis, EDS, and XRD techniques	462:500	The ST-Zn-Se-NPs-AC composite was characterized by FE-SEM, UV-Vis, EDS, and XRD techniques.
32092426	6	56	theme	removal	1083:1089	arg1	percentage					1091:1100	The maximum removal percentage	1071:1100	The maximum removal percentage of 99.34%	1071:1110	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	57	theme	optimum	1158:1164	arg1	conditions					1166:1175	the optimum conditions	1154:1175	the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time)	1154:1282	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	5	58	theme	model	960:964	arg1	performance					931:941	the performance	927:941	the performance of the predicted model for predicting of real optimum points	927:1002	A good agreement between the experimental and predicted data was achieved by the predicted model that showed the performance of the predicted model for predicting of real optimum points, and it was successfully employed to remove BF from aqueous media.
32092426	6	59	theme	maximum	1075:1081	arg1	percentage					1091:1100	The maximum removal percentage	1071:1100	The maximum removal percentage of 99.34%	1071:1110	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	1	60	theme	selenide	237:244	arg1	nanoparticles					246:258	the starch-capped zinc selenide nanoparticles	214:258	the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite	214:313	In this study, the starch-capped zinc selenide nanoparticles loaded on activated carbon (ST-Zn-Se-NPs-AC) composite was fabricated, and then it was used for removing Basic Fuchsin (BF) dye from aqueous solution.
32092426	0	61	theme	surface	178:184	arg1	methodology					186:196	response surface methodology	169:196	response surface methodology	169:196	Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology.
32092426	3	62	theme	sonication	631:640	arg1	time					623:626	time	623:626	time of sonication	623:640	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	62	theme	sonication	631:640	arg1	dosage					598:603	dosage	598:603	dosage of adsorbent	598:616	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	62	theme	sonication	631:640	arg1	pH					594:595	pH	594:595	pH	594:595	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	62	theme	sonication	631:640	arg1	concentration					579:591	initial BF concentration	568:591	initial BF concentration	568:591	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	63	theme	adsorbent	608:616	arg1	time					623:626	time	623:626	time of sonication	623:640	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	63	theme	adsorbent	608:616	arg1	dosage					598:603	dosage	598:603	dosage of adsorbent	598:616	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	63	theme	adsorbent	608:616	arg1	pH					594:595	pH	594:595	pH	594:595	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	3	63	theme	adsorbent	608:616	arg1	concentration					579:591	initial BF concentration	568:591	initial BF concentration	568:591	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
32092426	5	64	theme	predicted	864:872	arg1	data					874:877	predicted data	864:877	predicted data	864:877	A good agreement between the experimental and predicted data was achieved by the predicted model that showed the performance of the predicted model for predicting of real optimum points, and it was successfully employed to remove BF from aqueous media.
32092426	0	65	theme	Basic	80:84	arg1	Fuchsin					86:92	Basic Fuchsin	80:92	Basic Fuchsin	80:92	Modeling and optimization of ultrasound-assisted high performance adsorption of Basic Fuchsin by starch-capped zinc selenide nanoparticles/AC as a novel composite using response surface methodology.
32092426	5	66	theme	good	820:823	arg1	agreement					825:833	A good agreement	818:833	A good agreement between the experimental and predicted data	818:877	A good agreement between the experimental and predicted data was achieved by the predicted model that showed the performance of the predicted model for predicting of real optimum points, and it was successfully employed to remove BF from aqueous media.
32092426	4	67	theme	independent	767:777	arg1	variables					793:801	the independent and dependent variables	763:801	the independent and dependent variables	763:801	The quadratic model between the independent and dependent variables was predicted.
32092426	6	68	theme	experimental	1313:1324	arg1	value					1326:1330	the experimental value	1309:1330	the experimental value (99.00%)	1309:1339	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	68	theme	experimental	1313:1324	arg1	%					1338:1338	99.00%	1333:1338	99.00%	1333:1338	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	6	68	theme	experimental	1313:1324	arg1	which					1285:1289	which	1285:1289	which	1285:1289	The maximum removal percentage of 99.34% was obtained by the predicted model under the optimum conditions (15 mg L-1 of initial BF concentration, pH of 7.0, 12 mg of ST-Zn-Se-NPs-AC, and 6 min of sonication time), which was very close to the experimental value (99.00%).
32092426	3	69	theme	removal	507:513	arg1	dependence					526:535	The removal percentage dependence	503:535	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication	503:640	The removal percentage dependence to different variables such as initial BF concentration, pH, dosage of adsorbent, and time of sonication was investigated by Central Composite Design (CCD) under Response Surface Methodology (RSM).
33233188	0	0	theme	fruits	94:99	arg1	structures					23:32	Dietary fiber chemical structures	0:32	Dietary fiber chemical structures	0:32	Dietary fiber chemical structures and physicochemical properties of edible Pouteria glomerata fruits, native from Brazilian Pantanal.
33233188	0	0	theme	fruits	94:99	arg1	properties					54:63	physicochemical properties	38:63	physicochemical properties	38:63	Dietary fiber chemical structures and physicochemical properties of edible Pouteria glomerata fruits, native from Brazilian Pantanal.
33233188	6	1	theme	dietary	947:953	arg1	fiber					955:959	insoluble dietary fiber	937:959	insoluble dietary fiber	937:959	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	5	2	theme	fiber	649:653	arg1	fractions					655:663	Soluble and insoluble dietary fiber fractions	619:663	Soluble and insoluble dietary fiber fractions	619:663	Soluble and insoluble dietary fiber fractions were obtained by the standard enzymatic-gravimetric method and chemically characterized by monosaccharide composition, gel permeation and NMR spectroscopy.
33233188	6	3	theme	vitamin	916:922	arg1	C					924:924	vitamin C	916:924	vitamin C	916:924	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	1	4	theme	native	158:163	arg1	glomerata					143:151	Pouteria glomerata	134:151	Pouteria glomerata	134:151	Pouteria glomerata is a native species from the Brazilian Pantanal, whose fruit is edible and still underexploited.
33233188	1	4	theme	native	158:163	arg1	species					165:171	a native species	156:171	a native species	156:171	Pouteria glomerata is a native species from the Brazilian Pantanal, whose fruit is edible and still underexploited.
33233188	0	5	theme	glomerata	84:92	arg1	fruits					94:99	edible Pouteria glomerata fruits	68:99	edible Pouteria glomerata fruits	68:99	Dietary fiber chemical structures and physicochemical properties of edible Pouteria glomerata fruits, native from Brazilian Pantanal.
33233188	6	6	theme	insoluble	937:945	arg1	fiber					955:959	insoluble dietary fiber	937:959	insoluble dietary fiber	937:959	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	7	7	theme	soluble	982:988	arg1	fiber					998:1002	The soluble dietary fiber	978:1002	The soluble dietary fiber	978:1002	The soluble dietary fiber was mainly composed of uronic acids, arabinose, and galactose, and NMR analysis indicated the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan as pectic polysaccharides.
33233188	7	8	theme	homogalacturonan	1134:1149	arg1	presence					1098:1105	the presence	1094:1105	the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan	1094:1182	The soluble dietary fiber was mainly composed of uronic acids, arabinose, and galactose, and NMR analysis indicated the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan as pectic polysaccharides.
33233188	7	8	theme	homogalacturonan	1134:1149	arg1	polysaccharides					1194:1208	pectic polysaccharides	1187:1208	pectic polysaccharides	1187:1208	The soluble dietary fiber was mainly composed of uronic acids, arabinose, and galactose, and NMR analysis indicated the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan as pectic polysaccharides.
33233188	0	9	theme	native	102:107	arg1	fruits					94:99	edible Pouteria glomerata fruits	68:99	edible Pouteria glomerata fruits	68:99	Dietary fiber chemical structures and physicochemical properties of edible Pouteria glomerata fruits, native from Brazilian Pantanal.
33233188	8	10	from	present	1226:1232	arg1	fraction					1261:1268	insoluble dietary fiber fraction	1237:1268	insoluble dietary fiber fraction	1237:1268	Hemicelluloses present in insoluble dietary fiber fraction were solubilized by alkaline treatment, and characterized as (1 → 4)-β-D-xylan.
33233188	7	11	theme	dietary	990:996	arg1	fiber					998:1002	The soluble dietary fiber	978:1002	The soluble dietary fiber	978:1002	The soluble dietary fiber was mainly composed of uronic acids, arabinose, and galactose, and NMR analysis indicated the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan as pectic polysaccharides.
33233188	6	12	theme	glomerata	844:852	arg1	fruits					854:859	P. glomerata fruits	841:859	P. glomerata fruits	841:859	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	3	13	theme	antioxidant	508:518	arg1	capacity					520:527	the antioxidant capacity	504:527	the antioxidant capacity	504:527	DPPH and ORAC methods were used to determine the antioxidant capacity.
33233188	4	14	theme	plasma	581:586	arg1	spectrometry					605:616	inductively coupled plasma optical emission spectrometry	561:616	inductively coupled plasma optical emission spectrometry	561:616	Minerals were quantified using inductively coupled plasma optical emission spectrometry.
33233188	5	15	theme	monosaccharide	756:769	arg1	composition					771:781	monosaccharide composition	756:781	monosaccharide composition	756:781	Soluble and insoluble dietary fiber fractions were obtained by the standard enzymatic-gravimetric method and chemically characterized by monosaccharide composition, gel permeation and NMR spectroscopy.
33233188	6	16	theme	minerals	927:934	arg1	capacity					888:895	high antioxidant capacity	871:895	high antioxidant capacity	871:895	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	6	16	theme	minerals	927:934	arg1	levels					906:911	high levels	901:911	high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid	901:975	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	7	17	theme	methylesterified	1117:1132	arg1	homogalacturonan					1134:1149	homogalacturonan	1134:1149	homogalacturonan	1134:1149	The soluble dietary fiber was mainly composed of uronic acids, arabinose, and galactose, and NMR analysis indicated the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan as pectic polysaccharides.
33233188	6	18	theme	P.	841:842	arg1	fruits					854:859	P. glomerata fruits	841:859	P. glomerata fruits	841:859	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	3	19	dep	DPPH	459:462	arg1	methods					473:479	methods	473:479	methods	473:479	DPPH and ORAC methods were used to determine the antioxidant capacity.
33233188	4	20	theme	coupled	573:579	arg1	spectrometry					605:616	inductively coupled plasma optical emission spectrometry	561:616	inductively coupled plasma optical emission spectrometry	561:616	Minerals were quantified using inductively coupled plasma optical emission spectrometry.
33233188	0	21	theme	Brazilian	114:122	arg1	Pantanal					124:131	Brazilian Pantanal	114:131	Brazilian Pantanal	114:131	Dietary fiber chemical structures and physicochemical properties of edible Pouteria glomerata fruits, native from Brazilian Pantanal.
33233188	5	22	theme	Soluble	619:625	arg1	fractions					655:663	Soluble and insoluble dietary fiber fractions	619:663	Soluble and insoluble dietary fiber fractions	619:663	Soluble and insoluble dietary fiber fractions were obtained by the standard enzymatic-gravimetric method and chemically characterized by monosaccharide composition, gel permeation and NMR spectroscopy.
33233188	2	23	theme	study	272:276	arg1	objective					254:262	The objective	250:262	The objective of this study	250:276	The objective of this study was to carried out the chemical, nutritional and antioxidant properties of this tropical fruit, as well as to isolate e characterize the chemical strucutre of their dietary fibers.
33233188	8	24	theme	insoluble	1237:1245	arg1	fraction					1261:1268	insoluble dietary fiber fraction	1237:1268	insoluble dietary fiber fraction	1237:1268	Hemicelluloses present in insoluble dietary fiber fraction were solubilized by alkaline treatment, and characterized as (1 → 4)-β-D-xylan.
33233188	8	25	theme	alkaline	1290:1297	arg1	treatment					1299:1307	alkaline treatment	1290:1307	alkaline treatment	1290:1307	Hemicelluloses present in insoluble dietary fiber fraction were solubilized by alkaline treatment, and characterized as (1 → 4)-β-D-xylan.
33233188	6	26	theme	C	924:924	arg1	capacity					888:895	high antioxidant capacity	871:895	high antioxidant capacity	871:895	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	6	26	theme	C	924:924	arg1	levels					906:911	high levels	901:911	high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid	901:975	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	0	27	theme	physicochemical	38:52	arg1	properties					54:63	physicochemical properties	38:63	physicochemical properties	38:63	Dietary fiber chemical structures and physicochemical properties of edible Pouteria glomerata fruits, native from Brazilian Pantanal.
33233188	0	28	theme	Dietary	0:6	arg1	fiber					8:12	Dietary fiber	0:12	Dietary fiber chemical structures	0:32	Dietary fiber chemical structures and physicochemical properties of edible Pouteria glomerata fruits, native from Brazilian Pantanal.
33233188	0	29	theme	fiber	8:12	arg1	structures					23:32	Dietary fiber chemical structures	0:32	Dietary fiber chemical structures	0:32	Dietary fiber chemical structures and physicochemical properties of edible Pouteria glomerata fruits, native from Brazilian Pantanal.
33233188	5	30	theme	NMR	803:805	arg1	spectroscopy					807:818	NMR spectroscopy	803:818	NMR spectroscopy	803:818	Soluble and insoluble dietary fiber fractions were obtained by the standard enzymatic-gravimetric method and chemically characterized by monosaccharide composition, gel permeation and NMR spectroscopy.
33233188	5	31	theme	insoluble	631:639	arg1	fractions					655:663	Soluble and insoluble dietary fiber fractions	619:663	Soluble and insoluble dietary fiber fractions	619:663	Soluble and insoluble dietary fiber fractions were obtained by the standard enzymatic-gravimetric method and chemically characterized by monosaccharide composition, gel permeation and NMR spectroscopy.
33233188	5	32	theme	gel	784:786	arg1	permeation					788:797	gel permeation	784:797	gel permeation	784:797	Soluble and insoluble dietary fiber fractions were obtained by the standard enzymatic-gravimetric method and chemically characterized by monosaccharide composition, gel permeation and NMR spectroscopy.
33233188	2	33	theme	chemical	301:308	arg1	properties					339:348	the chemical, nutritional and antioxidant properties	297:348	the chemical, nutritional and antioxidant properties of this tropical fruit	297:371	The objective of this study was to carried out the chemical, nutritional and antioxidant properties of this tropical fruit, as well as to isolate e characterize the chemical strucutre of their dietary fibers.
33233188	1	34	theme	Brazilian	182:190	arg1	Pantanal					192:199	the Brazilian Pantanal	178:199	the Brazilian Pantanal	178:199	Pouteria glomerata is a native species from the Brazilian Pantanal, whose fruit is edible and still underexploited.
33233188	2	35	theme	chemical	415:422	arg1	strucutre					424:432	the chemical strucutre	411:432	the chemical strucutre of their dietary fibers	411:456	The objective of this study was to carried out the chemical, nutritional and antioxidant properties of this tropical fruit, as well as to isolate e characterize the chemical strucutre of their dietary fibers.
33233188	9	36	theme	chemical	1373:1380	arg1	information					1382:1392	new chemical information	1369:1392	new chemical information about this native fruit	1369:1416	The results brings new chemical information about this native fruit and may open new opportunities for using it as a potential ingredient for health improvement by human comsumption.
33233188	5	37	theme	dietary	641:647	arg1	fractions					655:663	Soluble and insoluble dietary fiber fractions	619:663	Soluble and insoluble dietary fiber fractions	619:663	Soluble and insoluble dietary fiber fractions were obtained by the standard enzymatic-gravimetric method and chemically characterized by monosaccharide composition, gel permeation and NMR spectroscopy.
33233188	2	38	theme	fruit	367:371	arg1	properties					339:348	the chemical, nutritional and antioxidant properties	297:348	the chemical, nutritional and antioxidant properties of this tropical fruit	297:371	The objective of this study was to carried out the chemical, nutritional and antioxidant properties of this tropical fruit, as well as to isolate e characterize the chemical strucutre of their dietary fibers.
33233188	7	39	theme	pectic	1187:1192	arg1	presence					1098:1105	the presence	1094:1105	the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan	1094:1182	The soluble dietary fiber was mainly composed of uronic acids, arabinose, and galactose, and NMR analysis indicated the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan as pectic polysaccharides.
33233188	7	39	theme	pectic	1187:1192	arg1	polysaccharides					1194:1208	pectic polysaccharides	1187:1208	pectic polysaccharides	1187:1208	The soluble dietary fiber was mainly composed of uronic acids, arabinose, and galactose, and NMR analysis indicated the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan as pectic polysaccharides.
33233188	7	40	theme	NMR	1071:1073	arg1	analysis					1075:1082	NMR analysis	1071:1082	NMR analysis	1071:1082	The soluble dietary fiber was mainly composed of uronic acids, arabinose, and galactose, and NMR analysis indicated the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan as pectic polysaccharides.
33233188	9	41	theme	potential	1467:1475	arg1	it					1459:1460	it	1459:1460	it	1459:1460	The results brings new chemical information about this native fruit and may open new opportunities for using it as a potential ingredient for health improvement by human comsumption.
33233188	9	41	theme	potential	1467:1475	arg1	ingredient					1477:1486	a potential ingredient	1465:1486	a potential ingredient for health improvement by human comsumption	1465:1530	The results brings new chemical information about this native fruit and may open new opportunities for using it as a potential ingredient for health improvement by human comsumption.
33233188	0	42	theme	chemical	14:21	arg1	structures					23:32	Dietary fiber chemical structures	0:32	Dietary fiber chemical structures	0:32	Dietary fiber chemical structures and physicochemical properties of edible Pouteria glomerata fruits, native from Brazilian Pantanal.
33233188	7	43	theme	arabinogalactan	1168:1182	arg1	presence					1098:1105	the presence	1094:1105	the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan	1094:1182	The soluble dietary fiber was mainly composed of uronic acids, arabinose, and galactose, and NMR analysis indicated the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan as pectic polysaccharides.
33233188	7	43	theme	arabinogalactan	1168:1182	arg1	polysaccharides					1194:1208	pectic polysaccharides	1187:1208	pectic polysaccharides	1187:1208	The soluble dietary fiber was mainly composed of uronic acids, arabinose, and galactose, and NMR analysis indicated the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan as pectic polysaccharides.
33233188	2	44	theme	fibers	451:456	arg1	strucutre					424:432	the chemical strucutre	411:432	the chemical strucutre of their dietary fibers	411:456	The objective of this study was to carried out the chemical, nutritional and antioxidant properties of this tropical fruit, as well as to isolate e characterize the chemical strucutre of their dietary fibers.
33233188	8	45	attach	present	1226:1232	arg2	Hemicelluloses					1211:1224	Hemicelluloses	1211:1224	Hemicelluloses present in insoluble dietary fiber fraction	1211:1268	Hemicelluloses present in insoluble dietary fiber fraction were solubilized by alkaline treatment, and characterized as (1 → 4)-β-D-xylan.
33233188	8	45	attach	present	1226:1232	arg1	fraction					1261:1268	insoluble dietary fiber fraction	1237:1268	insoluble dietary fiber fraction	1237:1268	Hemicelluloses present in insoluble dietary fiber fraction were solubilized by alkaline treatment, and characterized as (1 → 4)-β-D-xylan.
33233188	8	45	attach	present	1226:1232	arg2	-β-D-xylan					1338:1347	(1 → 4)-β-D-xylan	1331:1347	(1 → 4)-β-D-xylan	1331:1347	Hemicelluloses present in insoluble dietary fiber fraction were solubilized by alkaline treatment, and characterized as (1 → 4)-β-D-xylan.
33233188	9	46	theme	health	1492:1497	arg1	improvement					1499:1509	health improvement	1492:1509	health improvement by human comsumption	1492:1530	The results brings new chemical information about this native fruit and may open new opportunities for using it as a potential ingredient for health improvement by human comsumption.
33233188	9	47	theme	human	1514:1518	arg1	comsumption					1520:1530	human comsumption	1514:1530	human comsumption	1514:1530	The results brings new chemical information about this native fruit and may open new opportunities for using it as a potential ingredient for health improvement by human comsumption.
33233188	2	48	theme	dietary	443:449	arg1	fibers					451:456	their dietary fibers	437:456	their dietary fibers	437:456	The objective of this study was to carried out the chemical, nutritional and antioxidant properties of this tropical fruit, as well as to isolate e characterize the chemical strucutre of their dietary fibers.
33233188	2	49	contain	carried	285:291	arg1	objective					254:262	The objective	250:262	The objective of this study	250:276	The objective of this study was to carried out the chemical, nutritional and antioxidant properties of this tropical fruit, as well as to isolate e characterize the chemical strucutre of their dietary fibers.
33233188	2	49	contain	carried	285:291	arg2	properties					339:348	the chemical, nutritional and antioxidant properties	297:348	the chemical, nutritional and antioxidant properties of this tropical fruit	297:371	The objective of this study was to carried out the chemical, nutritional and antioxidant properties of this tropical fruit, as well as to isolate e characterize the chemical strucutre of their dietary fibers.
33233188	8	50	theme	fiber	1255:1259	arg1	fraction					1261:1268	insoluble dietary fiber fraction	1237:1268	insoluble dietary fiber fraction	1237:1268	Hemicelluloses present in insoluble dietary fiber fraction were solubilized by alkaline treatment, and characterized as (1 → 4)-β-D-xylan.
33233188	6	51	theme	high	901:904	arg1	levels					906:911	high levels	901:911	high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid	901:975	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	8	52	theme	dietary	1247:1253	arg1	fraction					1261:1268	insoluble dietary fiber fraction	1237:1268	insoluble dietary fiber fraction	1237:1268	Hemicelluloses present in insoluble dietary fiber fraction were solubilized by alkaline treatment, and characterized as (1 → 4)-β-D-xylan.
33233188	7	53	theme	arabinan	1152:1159	arg1	presence					1098:1105	the presence	1094:1105	the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan	1094:1182	The soluble dietary fiber was mainly composed of uronic acids, arabinose, and galactose, and NMR analysis indicated the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan as pectic polysaccharides.
33233188	7	53	theme	arabinan	1152:1159	arg1	polysaccharides					1194:1208	pectic polysaccharides	1187:1208	pectic polysaccharides	1187:1208	The soluble dietary fiber was mainly composed of uronic acids, arabinose, and galactose, and NMR analysis indicated the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan as pectic polysaccharides.
33233188	6	54	theme	acid	972:975	arg1	capacity					888:895	high antioxidant capacity	871:895	high antioxidant capacity	871:895	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	6	54	theme	acid	972:975	arg1	levels					906:911	high levels	901:911	high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid	901:975	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	8	55	from	fraction	1261:1268	arg1	present					1226:1232	present	1226:1232	present	1226:1232	Hemicelluloses present in insoluble dietary fiber fraction were solubilized by alkaline treatment, and characterized as (1 → 4)-β-D-xylan.
33233188	2	56	theme	antioxidant	327:337	arg1	properties					339:348	the chemical, nutritional and antioxidant properties	297:348	the chemical, nutritional and antioxidant properties of this tropical fruit	297:371	The objective of this study was to carried out the chemical, nutritional and antioxidant properties of this tropical fruit, as well as to isolate e characterize the chemical strucutre of their dietary fibers.
33233188	4	57	theme	optical	588:594	arg1	spectrometry					605:616	inductively coupled plasma optical emission spectrometry	561:616	inductively coupled plasma optical emission spectrometry	561:616	Minerals were quantified using inductively coupled plasma optical emission spectrometry.
33233188	9	58	theme	new	1431:1433	arg1	opportunities					1435:1447	new opportunities	1431:1447	new opportunities for using it as a potential ingredient for health improvement by human comsumption	1431:1530	The results brings new chemical information about this native fruit and may open new opportunities for using it as a potential ingredient for health improvement by human comsumption.
33233188	8	59	theme	1 → 4	1332:1336	arg1	-β-D-xylan					1338:1347	(1 → 4)-β-D-xylan	1331:1347	(1 → 4)-β-D-xylan	1331:1347	Hemicelluloses present in insoluble dietary fiber fraction were solubilized by alkaline treatment, and characterized as (1 → 4)-β-D-xylan.
33233188	8	59	theme	1 → 4	1332:1336	arg1	Hemicelluloses					1211:1224	Hemicelluloses	1211:1224	Hemicelluloses present in insoluble dietary fiber fraction	1211:1268	Hemicelluloses present in insoluble dietary fiber fraction were solubilized by alkaline treatment, and characterized as (1 → 4)-β-D-xylan.
33233188	5	60	theme	standard	686:693	arg1	method					717:722	the standard enzymatic-gravimetric method	682:722	the standard enzymatic-gravimetric method	682:722	Soluble and insoluble dietary fiber fractions were obtained by the standard enzymatic-gravimetric method and chemically characterized by monosaccharide composition, gel permeation and NMR spectroscopy.
33233188	6	61	theme	antioxidant	876:886	arg1	capacity					888:895	high antioxidant capacity	871:895	high antioxidant capacity	871:895	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	7	62	theme	uronic	1027:1032	arg1	acids					1034:1038	uronic acids	1027:1038	uronic acids	1027:1038	The soluble dietary fiber was mainly composed of uronic acids, arabinose, and galactose, and NMR analysis indicated the presence of highly methylesterified homogalacturonan, arabinan and/or arabinogalactan as pectic polysaccharides.
33233188	1	63	theme	Pouteria	134:141	arg1	glomerata					143:151	Pouteria glomerata	134:151	Pouteria glomerata	134:151	Pouteria glomerata is a native species from the Brazilian Pantanal, whose fruit is edible and still underexploited.
33233188	1	63	theme	Pouteria	134:141	arg1	species					165:171	a native species	156:171	a native species	156:171	Pouteria glomerata is a native species from the Brazilian Pantanal, whose fruit is edible and still underexploited.
33233188	4	64	theme	emission	596:603	arg1	spectrometry					605:616	inductively coupled plasma optical emission spectrometry	561:616	inductively coupled plasma optical emission spectrometry	561:616	Minerals were quantified using inductively coupled plasma optical emission spectrometry.
33233188	5	65	theme	enzymatic-gravimetric	695:715	arg1	method					717:722	the standard enzymatic-gravimetric method	682:722	the standard enzymatic-gravimetric method	682:722	Soluble and insoluble dietary fiber fractions were obtained by the standard enzymatic-gravimetric method and chemically characterized by monosaccharide composition, gel permeation and NMR spectroscopy.
33233188	6	66	theme	high	871:874	arg1	capacity					888:895	high antioxidant capacity	871:895	high antioxidant capacity	871:895	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	8	67	theme	present	1226:1232	arg1	-β-D-xylan					1338:1347	(1 → 4)-β-D-xylan	1331:1347	(1 → 4)-β-D-xylan	1331:1347	Hemicelluloses present in insoluble dietary fiber fraction were solubilized by alkaline treatment, and characterized as (1 → 4)-β-D-xylan.
33233188	8	67	theme	present	1226:1232	arg1	Hemicelluloses					1211:1224	Hemicelluloses	1211:1224	Hemicelluloses present in insoluble dietary fiber fraction	1211:1268	Hemicelluloses present in insoluble dietary fiber fraction were solubilized by alkaline treatment, and characterized as (1 → 4)-β-D-xylan.
33233188	9	68	theme	native	1405:1410	arg1	fruit					1412:1416	this native fruit	1400:1416	this native fruit	1400:1416	The results brings new chemical information about this native fruit and may open new opportunities for using it as a potential ingredient for health improvement by human comsumption.
33233188	2	69	theme	nutritional	311:321	arg1	properties					339:348	the chemical, nutritional and antioxidant properties	297:348	the chemical, nutritional and antioxidant properties of this tropical fruit	297:371	The objective of this study was to carried out the chemical, nutritional and antioxidant properties of this tropical fruit, as well as to isolate e characterize the chemical strucutre of their dietary fibers.
33233188	0	70	theme	Pouteria	75:82	arg1	fruits					94:99	edible Pouteria glomerata fruits	68:99	edible Pouteria glomerata fruits	68:99	Dietary fiber chemical structures and physicochemical properties of edible Pouteria glomerata fruits, native from Brazilian Pantanal.
33233188	1	71	from	Pantanal	192:199	arg1	glomerata					143:151	Pouteria glomerata	134:151	Pouteria glomerata	134:151	Pouteria glomerata is a native species from the Brazilian Pantanal, whose fruit is edible and still underexploited.
33233188	1	71	from	Pantanal	192:199	arg1	species					165:171	a native species	156:171	a native species	156:171	Pouteria glomerata is a native species from the Brazilian Pantanal, whose fruit is edible and still underexploited.
33233188	2	72	theme	tropical	358:365	arg1	fruit					367:371	this tropical fruit	353:371	this tropical fruit	353:371	The objective of this study was to carried out the chemical, nutritional and antioxidant properties of this tropical fruit, as well as to isolate e characterize the chemical strucutre of their dietary fibers.
33233188	0	73	theme	edible	68:73	arg1	fruits					94:99	edible Pouteria glomerata fruits	68:99	edible Pouteria glomerata fruits	68:99	Dietary fiber chemical structures and physicochemical properties of edible Pouteria glomerata fruits, native from Brazilian Pantanal.
33233188	6	74	theme	fiber	955:959	arg1	capacity					888:895	high antioxidant capacity	871:895	high antioxidant capacity	871:895	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	6	74	theme	fiber	955:959	arg1	levels					906:911	high levels	901:911	high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid	901:975	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	3	75	used	used	486:489	arg2	ORAC					468:471	ORAC	468:471	ORAC	468:471	DPPH and ORAC methods were used to determine the antioxidant capacity.
33233188	3	75	used	used	486:489	arg2	DPPH					459:462	DPPH	459:462	DPPH	459:462	DPPH and ORAC methods were used to determine the antioxidant capacity.
33233188	9	76	theme	new	1369:1371	arg1	information					1382:1392	new chemical information	1369:1392	new chemical information about this native fruit	1369:1416	The results brings new chemical information about this native fruit and may open new opportunities for using it as a potential ingredient for health improvement by human comsumption.
33233188	6	77	theme	malic	966:970	arg1	acid					972:975	malic acid	966:975	malic acid	966:975	Results showed that P. glomerata fruits presented high antioxidant capacity and high levels of vitamin C, minerals, insoluble dietary fiber, and malic acid.
33233188	0	78	from	Pantanal	124:131	arg1	native					102:107	native	102:107	native	102:107	Dietary fiber chemical structures and physicochemical properties of edible Pouteria glomerata fruits, native from Brazilian Pantanal.
33675271	6	0	theme	optimal	1129:1135	arg1	conditions					1137:1146	optimal conditions	1129:1146	optimal conditions	1129:1146	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	6	1	theme	pulse	1275:1279	arg1	voltammogram					1281:1292	differential pulse voltammogram	1262:1292	differential pulse voltammogram (DPV)	1262:1298	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	6	1	theme	pulse	1275:1279	arg1	DPV					1295:1297	DPV	1295:1297	DPV	1295:1297	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	1	2	theme	life	190:193	arg1	sciences					195:202	life sciences	190:202	life sciences	190:202	Due to the crucial role of amino acids in life sciences and pharmaceutics, identification of optical amino acid molecules is of great significance.
33675271	3	3	theme	conductive	584:593	arg1	material					595:602	conductive material	584:602	conductive material	584:602	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	4	4	theme	electrochemical	676:690	arg1	interface					700:708	a novel electrochemical sensing interface	668:708	a novel electrochemical sensing interface	668:708	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	11	5	theme	material	1867:1874	arg1	preparation					1842:1852	the preparation	1838:1852	the preparation of substrate material with excellent electrical conductivity	1838:1913	This work inspires us a new path for the preparation of substrate material with excellent electrical conductivity, as well as extend its application potential in chiral recognition.
33675271	3	6	theme	electrochemical	627:641	arg1	interface					651:659	the electrochemical sensing interface	623:659	the electrochemical sensing interface	623:659	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	3	6	theme	electrochemical	627:641	arg1	nanocomposite					548:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite	455:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material	455:602	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	5	7	theme	stereoselective	970:984	arg1	recognition					986:996	stereoselective recognition	970:996	stereoselective recognition	970:996	It was observed that CNT/PANI/SA/GCE showed desirable stereoselective recognition effect in the variety of signal strength to peak current (Ip) to the different optical activity of Trp enantiomers.
33675271	8	8	theme	incubation	1484:1493	arg1	time					1495:1498	the incubation time	1480:1498	the incubation time	1480:1498	Also different factors affecting the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA were optimized.
33675271	7	9	theme	greater	1363:1369	arg1	energy					1379:1384	a greater binding energy	1361:1384	a greater binding energy	1361:1384	UV-visible spectroscopy further showed that CNT/PANI/SA had a greater binding energy to l-Trp.
33675271	2	10	dep	materials	319:327	arg1	PANI					338:341	PANI	338:341	PANI	338:341	In this study, the two materials (CNT and PANI) were combined together to obtain the magnification of electrochemical signal by substrate material (CNT/PANI).
33675271	2	10	dep	materials	319:327	arg1	CNT					330:332	CNT	330:332	CNT	330:332	In this study, the two materials (CNT and PANI) were combined together to obtain the magnification of electrochemical signal by substrate material (CNT/PANI).
33675271	2	10	dep	materials	319:327	arg1	materials					319:327	the two materials	311:327	the two materials (CNT and PANI)	311:342	In this study, the two materials (CNT and PANI) were combined together to obtain the magnification of electrochemical signal by substrate material (CNT/PANI).
33675271	5	11	theme	Trp	1097:1099	arg1	enantiomers					1101:1111	Trp enantiomers	1097:1111	Trp enantiomers	1097:1111	It was observed that CNT/PANI/SA/GCE showed desirable stereoselective recognition effect in the variety of signal strength to peak current (Ip) to the different optical activity of Trp enantiomers.
33675271	1	12	theme	crucial	159:165	arg1	role					167:170	the crucial role	155:170	the crucial role of amino acids in life sciences and pharmaceutics	155:220	Due to the crucial role of amino acids in life sciences and pharmaceutics, identification of optical amino acid molecules is of great significance.
33675271	4	13	theme	as-prepared	743:753	arg1	material					762:769	the as-prepared chiral material	739:769	the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers	739:913	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	0	14	theme	multiwalled	80:90	arg1	composite					137:145	a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite	63:145	a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite	63:145	Chiral voltammetric sensor for tryptophan enantiomers by using a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite.
33675271	1	15	theme	acids	181:185	arg1	role					167:170	the crucial role	155:170	the crucial role of amino acids in life sciences and pharmaceutics	155:220	Due to the crucial role of amino acids in life sciences and pharmaceutics, identification of optical amino acid molecules is of great significance.
33675271	8	16	theme	dropcoating	1509:1519	arg1	volume					1521:1526	dropcoating volume	1509:1526	dropcoating volume of CNT/PANI/SA	1509:1541	Also different factors affecting the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA were optimized.
33675271	0	17	theme	nanotubes/polyaniline/sodium	99:126	arg1	composite					137:145	a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite	63:145	a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite	63:145	Chiral voltammetric sensor for tryptophan enantiomers by using a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite.
33675271	1	18	from	role	167:170	arg1	sciences					195:202	life sciences	190:202	life sciences	190:202	Due to the crucial role of amino acids in life sciences and pharmaceutics, identification of optical amino acid molecules is of great significance.
33675271	1	18	from	role	167:170	arg1	pharmaceutics					208:220	pharmaceutics	208:220	pharmaceutics	208:220	Due to the crucial role of amino acids in life sciences and pharmaceutics, identification of optical amino acid molecules is of great significance.
33675271	5	19	theme	strength	1030:1037	arg1	variety					1012:1018	the variety	1008:1018	the variety of signal strength	1008:1037	It was observed that CNT/PANI/SA/GCE showed desirable stereoselective recognition effect in the variety of signal strength to peak current (Ip) to the different optical activity of Trp enantiomers.
33675271	5	19	theme	strength	1030:1037	arg1	strength					1030:1037	signal strength	1023:1037	signal strength	1023:1037	It was observed that CNT/PANI/SA/GCE showed desirable stereoselective recognition effect in the variety of signal strength to peak current (Ip) to the different optical activity of Trp enantiomers.
33675271	5	20	dep	desirable	960:968	arg1	recognition					986:996	stereoselective recognition	970:996	stereoselective recognition	970:996	It was observed that CNT/PANI/SA/GCE showed desirable stereoselective recognition effect in the variety of signal strength to peak current (Ip) to the different optical activity of Trp enantiomers.
33675271	10	21	theme	sensing	1702:1708	arg1	platform					1710:1717	the proposed chiral sensing platform	1682:1717	the proposed chiral sensing platform	1682:1717	Besides, the proposed chiral sensing platform can be effectively applied in real samples to detect Trp enantiomers sensitively.
33675271	5	22	theme	peak	1042:1045	arg1	Ip					1056:1057	Ip	1056:1057	Ip	1056:1057	It was observed that CNT/PANI/SA/GCE showed desirable stereoselective recognition effect in the variety of signal strength to peak current (Ip) to the different optical activity of Trp enantiomers.
33675271	5	22	theme	peak	1042:1045	arg1	current					1047:1053	peak current	1042:1053	peak current (Ip) to the different optical activity of Trp enantiomers	1042:1111	It was observed that CNT/PANI/SA/GCE showed desirable stereoselective recognition effect in the variety of signal strength to peak current (Ip) to the different optical activity of Trp enantiomers.
33675271	4	23	theme	glassy	785:790	arg1	CNT/PANI/SA/GCE					810:824	CNT/PANI/SA/GCE	810:824	CNT/PANI/SA/GCE	810:824	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	4	23	theme	glassy	785:790	arg1	electrode					799:807	a polished glassy carbon electrode	774:807	a polished glassy carbon electrode (CNT/PANI/SA/GCE)	774:825	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	10	24	theme	proposed	1686:1693	arg1	platform					1710:1717	the proposed chiral sensing platform	1682:1717	the proposed chiral sensing platform	1682:1717	Besides, the proposed chiral sensing platform can be effectively applied in real samples to detect Trp enantiomers sensitively.
33675271	0	25	theme	Chiral	0:5	arg1	sensor					20:25	Chiral voltammetric sensor	0:25	Chiral voltammetric sensor for tryptophan	0:40	Chiral voltammetric sensor for tryptophan enantiomers by using a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite.
33675271	9	26	theme	excellent	1605:1613	arg1	stereoselectivity					1624:1640	excellent specific stereoselectivity	1605:1640	excellent specific stereoselectivity	1605:1640	Moreover, the proposed CNT/PANI/SA/GCE showed excellent specific stereoselectivity and anti-interference ability.
33675271	11	27	theme	chiral	1963:1968	arg1	recognition					1970:1980	chiral recognition	1963:1980	chiral recognition	1963:1980	This work inspires us a new path for the preparation of substrate material with excellent electrical conductivity, as well as extend its application potential in chiral recognition.
33675271	8	28	theme	different	1401:1409	arg1	factors					1411:1417	different factors	1401:1417	different factors affecting the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA	1401:1541	Also different factors affecting the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA were optimized.
33675271	2	29	theme	electrochemical	398:412	arg1	signal					414:419	electrochemical signal	398:419	electrochemical signal	398:419	In this study, the two materials (CNT and PANI) were combined together to obtain the magnification of electrochemical signal by substrate material (CNT/PANI).
33675271	3	30	theme	carbon	489:494	arg1	interface					651:659	the electrochemical sensing interface	623:659	the electrochemical sensing interface	623:659	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	3	30	theme	carbon	489:494	arg1	nanocomposite					548:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite	455:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material	455:602	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	8	31	dep	such	1472:1475	arg1	as					1477:1478	as	1477:1478	as	1477:1478	Also different factors affecting the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA were optimized.
33675271	9	32	theme	anti-interference	1646:1662	arg1	ability					1664:1670	anti-interference ability	1646:1670	anti-interference ability	1646:1670	Moreover, the proposed CNT/PANI/SA/GCE showed excellent specific stereoselectivity and anti-interference ability.
33675271	6	33	theme	current	1158:1164	arg1	2.1					1236:1238	2.1	1236:1238	2.1	1236:1238	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	6	33	theme	current	1158:1164	arg1	ratio					1166:1170	the peak current ratio	1149:1170	the peak current ratio in the solution of l-Trp and d-Trp (ID /IL )	1149:1215	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	3	34	theme	self-assembled	462:475	arg1	interface					651:659	the electrochemical sensing interface	623:659	the electrochemical sensing interface	623:659	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	3	34	theme	self-assembled	462:475	arg1	nanocomposite					548:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite	455:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material	455:602	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	1	35	theme	optical	241:247	arg1	molecules					260:268	optical amino acid molecules	241:268	optical amino acid molecules	241:268	Due to the crucial role of amino acids in life sciences and pharmaceutics, identification of optical amino acid molecules is of great significance.
33675271	8	36	theme	CNT/PANI/SA/GCE	1455:1469	arg1	enantioselectivity					1433:1450	the enantioselectivity	1429:1450	the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA	1429:1541	Also different factors affecting the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA were optimized.
33675271	3	37	theme	CNT/PANI/SA	535:545	arg1	interface					651:659	the electrochemical sensing interface	623:659	the electrochemical sensing interface	623:659	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	3	37	theme	CNT/PANI/SA	535:545	arg1	nanocomposite					548:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite	455:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material	455:602	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	1	38	theme	acid	255:258	arg1	molecules					260:268	optical amino acid molecules	241:268	optical amino acid molecules	241:268	Due to the crucial role of amino acids in life sciences and pharmaceutics, identification of optical amino acid molecules is of great significance.
33675271	6	39	theme	conditions	1137:1146	arg1	case					1121:1124	the case	1117:1124	the case of optimal conditions	1117:1146	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	3	40	theme	alginate	525:532	arg1	interface					651:659	the electrochemical sensing interface	623:659	the electrochemical sensing interface	623:659	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	3	40	theme	alginate	525:532	arg1	nanocomposite					548:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite	455:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material	455:602	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	6	41	from	CNT/PANI/SA/GCE	1243:1257	arg1	ratio					1166:1170	the peak current ratio	1149:1170	the peak current ratio in the solution of l-Trp and d-Trp (ID /IL )	1149:1215	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	6	41	from	CNT/PANI/SA/GCE	1243:1257	arg1	2.1					1236:1238	2.1	1236:1238	2.1	1236:1238	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	4	42	theme	enantiomers	903:913	arg1	differentiation					867:881	precisely, efficiently, and rapidly differentiation	831:881	precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers	831:913	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	3	43	theme	chiral	567:572	arg1	sites					574:578	chiral sites	567:578	chiral sites	567:578	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	1	44	theme	great	276:280	arg1	significance					282:293	great significance	276:293	great significance	276:293	Due to the crucial role of amino acids in life sciences and pharmaceutics, identification of optical amino acid molecules is of great significance.
33675271	6	45	theme	d-Trp	1201:1205	arg1	solution					1179:1186	the solution	1175:1186	the solution of l-Trp and d-Trp (ID /IL )	1175:1215	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	6	46	theme	differential	1262:1273	arg1	voltammogram					1281:1292	differential pulse voltammogram	1262:1292	differential pulse voltammogram (DPV)	1262:1298	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	6	46	theme	differential	1262:1273	arg1	DPV					1295:1297	DPV	1295:1297	DPV	1295:1297	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	4	47	theme	tryptophan	886:895	arg1	enantiomers					903:913	tryptophan (Trp) enantiomers	886:913	tryptophan (Trp) enantiomers	886:913	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	6	48	theme	l-Trp	1191:1195	arg1	solution					1179:1186	the solution	1175:1186	the solution of l-Trp and d-Trp (ID /IL )	1175:1215	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	4	49	theme	sensing	692:698	arg1	interface					700:708	a novel electrochemical sensing interface	668:708	a novel electrochemical sensing interface	668:708	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	5	50	theme	optical	1077:1083	arg1	activity					1085:1092	the different optical activity	1063:1092	the different optical activity of Trp enantiomers	1063:1111	It was observed that CNT/PANI/SA/GCE showed desirable stereoselective recognition effect in the variety of signal strength to peak current (Ip) to the different optical activity of Trp enantiomers.
33675271	3	51	theme	nanotubes/polyaniline/sodium	496:523	arg1	interface					651:659	the electrochemical sensing interface	623:659	the electrochemical sensing interface	623:659	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	3	51	theme	nanotubes/polyaniline/sodium	496:523	arg1	nanocomposite					548:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite	455:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material	455:602	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	4	52	theme	novel	670:674	arg1	interface					700:708	a novel electrochemical sensing interface	668:708	a novel electrochemical sensing interface	668:708	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	5	53	theme	desirable	960:968	arg1	effect					998:1003	desirable stereoselective recognition effect	960:1003	desirable stereoselective recognition effect	960:1003	It was observed that CNT/PANI/SA/GCE showed desirable stereoselective recognition effect in the variety of signal strength to peak current (Ip) to the different optical activity of Trp enantiomers.
33675271	8	54	theme	time	1495:1498	arg1	enantioselectivity					1433:1450	the enantioselectivity	1429:1450	the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA	1429:1541	Also different factors affecting the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA were optimized.
33675271	4	55	theme	chiral	755:760	arg1	material					762:769	the as-prepared chiral material	739:769	the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers	739:913	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	11	56	theme	substrate	1857:1865	arg1	material					1867:1874	substrate material	1857:1874	substrate material with excellent electrical conductivity	1857:1913	This work inspires us a new path for the preparation of substrate material with excellent electrical conductivity, as well as extend its application potential in chiral recognition.
33675271	11	57	dep	us	1820:1821	arg1	path					1829:1832	a new path	1823:1832	us a new path for the preparation of substrate material with excellent electrical conductivity	1820:1913	This work inspires us a new path for the preparation of substrate material with excellent electrical conductivity, as well as extend its application potential in chiral recognition.
33675271	8	58	theme	pH	1501:1502	arg1	enantioselectivity					1433:1450	the enantioselectivity	1429:1450	the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA	1429:1541	Also different factors affecting the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA were optimized.
33675271	7	59	theme	binding	1371:1377	arg1	energy					1379:1384	a greater binding energy	1361:1384	a greater binding energy	1361:1384	UV-visible spectroscopy further showed that CNT/PANI/SA had a greater binding energy to l-Trp.
33675271	11	60	theme	excellent	1881:1889	arg1	conductivity					1902:1913	excellent electrical conductivity	1881:1913	excellent electrical conductivity	1881:1913	This work inspires us a new path for the preparation of substrate material with excellent electrical conductivity, as well as extend its application potential in chiral recognition.
33675271	0	61	theme	self-assembled	65:78	arg1	composite					137:145	a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite	63:145	a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite	63:145	Chiral voltammetric sensor for tryptophan enantiomers by using a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite.
33675271	5	62	theme	enantiomers	1101:1111	arg1	activity					1085:1092	the different optical activity	1063:1092	the different optical activity of Trp enantiomers	1063:1111	It was observed that CNT/PANI/SA/GCE showed desirable stereoselective recognition effect in the variety of signal strength to peak current (Ip) to the different optical activity of Trp enantiomers.
33675271	3	63	theme	sensing	643:649	arg1	interface					651:659	the electrochemical sensing interface	623:659	the electrochemical sensing interface	623:659	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	3	63	theme	sensing	643:649	arg1	nanocomposite					548:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite	455:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material	455:602	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	6	64	theme	ID	1208:1209	arg1	d-Trp					1201:1205	d-Trp	1201:1205	d-Trp (ID /IL )	1201:1215	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	6	64	theme	ID	1208:1209	arg1	/IL					1211:1213	ID /IL	1208:1213	ID /IL	1208:1213	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	11	65	from	potential	1950:1958	arg1	recognition					1970:1980	chiral recognition	1963:1980	chiral recognition	1963:1980	This work inspires us a new path for the preparation of substrate material with excellent electrical conductivity, as well as extend its application potential in chiral recognition.
33675271	0	66	theme	carbon	92:97	arg1	composite					137:145	a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite	63:145	a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite	63:145	Chiral voltammetric sensor for tryptophan enantiomers by using a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite.
33675271	1	67	theme	amino	175:179	arg1	acids					181:185	amino acids	175:185	amino acids	175:185	Due to the crucial role of amino acids in life sciences and pharmaceutics, identification of optical amino acid molecules is of great significance.
33675271	8	68	theme	volume	1521:1526	arg1	enantioselectivity					1433:1450	the enantioselectivity	1429:1450	the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA	1429:1541	Also different factors affecting the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA were optimized.
33675271	11	69	theme	new	1825:1827	arg1	path					1829:1832	a new path	1823:1832	us a new path for the preparation of substrate material with excellent electrical conductivity	1820:1913	This work inspires us a new path for the preparation of substrate material with excellent electrical conductivity, as well as extend its application potential in chiral recognition.
33675271	0	70	theme	alginate	128:135	arg1	composite					137:145	a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite	63:145	a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite	63:145	Chiral voltammetric sensor for tryptophan enantiomers by using a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite.
33675271	11	71	with	material	1867:1874	arg1	conductivity					1902:1913	excellent electrical conductivity	1881:1913	excellent electrical conductivity	1881:1913	This work inspires us a new path for the preparation of substrate material with excellent electrical conductivity, as well as extend its application potential in chiral recognition.
33675271	5	72	theme	signal	1023:1028	arg1	strength					1030:1037	signal strength	1023:1037	signal strength	1023:1037	It was observed that CNT/PANI/SA/GCE showed desirable stereoselective recognition effect in the variety of signal strength to peak current (Ip) to the different optical activity of Trp enantiomers.
33675271	8	73	theme	CNT/PANI/SA	1531:1541	arg1	volume					1521:1526	dropcoating volume	1509:1526	dropcoating volume of CNT/PANI/SA	1509:1541	Also different factors affecting the enantioselectivity of CNT/PANI/SA/GCE, such as the incubation time, pH, and dropcoating volume of CNT/PANI/SA were optimized.
33675271	11	74	theme	electrical	1891:1900	arg1	conductivity					1902:1913	excellent electrical conductivity	1881:1913	excellent electrical conductivity	1881:1913	This work inspires us a new path for the preparation of substrate material with excellent electrical conductivity, as well as extend its application potential in chiral recognition.
33675271	1	75	theme	amino	249:253	arg1	molecules					260:268	optical amino acid molecules	241:268	optical amino acid molecules	241:268	Due to the crucial role of amino acids in life sciences and pharmaceutics, identification of optical amino acid molecules is of great significance.
33675271	10	76	theme	chiral	1695:1700	arg1	platform					1710:1717	the proposed chiral sensing platform	1682:1717	the proposed chiral sensing platform	1682:1717	Besides, the proposed chiral sensing platform can be effectively applied in real samples to detect Trp enantiomers sensitively.
33675271	0	77	theme	voltammetric	7:18	arg1	sensor					20:25	Chiral voltammetric sensor	0:25	Chiral voltammetric sensor for tryptophan	0:40	Chiral voltammetric sensor for tryptophan enantiomers by using a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate composite.
33675271	9	78	theme	proposed	1573:1580	arg1	CNT/PANI/SA/GCE					1582:1596	the proposed CNT/PANI/SA/GCE	1569:1596	the proposed CNT/PANI/SA/GCE	1569:1596	Moreover, the proposed CNT/PANI/SA/GCE showed excellent specific stereoselectivity and anti-interference ability.
33675271	4	79	theme	polished	776:783	arg1	CNT/PANI/SA/GCE					810:824	CNT/PANI/SA/GCE	810:824	CNT/PANI/SA/GCE	810:824	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	4	79	theme	polished	776:783	arg1	electrode					799:807	a polished glassy carbon electrode	774:807	a polished glassy carbon electrode (CNT/PANI/SA/GCE)	774:825	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	11	80	theme	application	1938:1948	arg1	potential					1950:1958	its application potential	1934:1958	its application potential in chiral recognition	1934:1980	This work inspires us a new path for the preparation of substrate material with excellent electrical conductivity, as well as extend its application potential in chiral recognition.
33675271	7	81	theme	UV-visible	1301:1310	arg1	spectroscopy					1312:1323	UV-visible spectroscopy	1301:1323	UV-visible spectroscopy	1301:1323	UV-visible spectroscopy further showed that CNT/PANI/SA had a greater binding energy to l-Trp.
33675271	2	82	theme	substrate	424:432	arg1	CNT/PANI					444:451	CNT/PANI	444:451	CNT/PANI	444:451	In this study, the two materials (CNT and PANI) were combined together to obtain the magnification of electrochemical signal by substrate material (CNT/PANI).
33675271	2	82	theme	substrate	424:432	arg1	material					434:441	substrate material	424:441	substrate material (CNT/PANI)	424:452	In this study, the two materials (CNT and PANI) were combined together to obtain the magnification of electrochemical signal by substrate material (CNT/PANI).
33675271	4	83	theme	carbon	792:797	arg1	CNT/PANI/SA/GCE					810:824	CNT/PANI/SA/GCE	810:824	CNT/PANI/SA/GCE	810:824	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	4	83	theme	carbon	792:797	arg1	electrode					799:807	a polished glassy carbon electrode	774:807	a polished glassy carbon electrode (CNT/PANI/SA/GCE)	774:825	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	2	84	theme	signal	414:419	arg1	magnification					381:393	the magnification	377:393	the magnification of electrochemical signal	377:419	In this study, the two materials (CNT and PANI) were combined together to obtain the magnification of electrochemical signal by substrate material (CNT/PANI).
33675271	3	85	with	nanocomposite	548:560	arg1	sites					574:578	chiral sites	567:578	chiral sites	567:578	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	3	85	with	nanocomposite	548:560	arg1	material					595:602	conductive material	584:602	conductive material	584:602	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	9	86	theme	specific	1615:1622	arg1	stereoselectivity					1624:1640	excellent specific stereoselectivity	1605:1640	excellent specific stereoselectivity	1605:1640	Moreover, the proposed CNT/PANI/SA/GCE showed excellent specific stereoselectivity and anti-interference ability.
33675271	5	87	theme	different	1067:1075	arg1	activity					1085:1092	the different optical activity	1063:1092	the different optical activity of Trp enantiomers	1063:1111	It was observed that CNT/PANI/SA/GCE showed desirable stereoselective recognition effect in the variety of signal strength to peak current (Ip) to the different optical activity of Trp enantiomers.
33675271	6	88	located	observed	1221:1228	arg2	ratio					1166:1170	the peak current ratio	1149:1170	the peak current ratio in the solution of l-Trp and d-Trp (ID /IL )	1149:1215	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	6	88	located	observed	1221:1228	arg2	2.1					1236:1238	2.1	1236:1238	2.1	1236:1238	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	6	88	located	observed	1221:1228	arg1	case					1121:1124	the case	1117:1124	the case of optimal conditions	1117:1146	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	6	89	from	ratio	1166:1170	arg1	solution					1179:1186	the solution	1175:1186	the solution of l-Trp and d-Trp (ID /IL )	1175:1215	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	10	90	theme	real	1749:1752	arg1	samples					1754:1760	real samples	1749:1760	real samples	1749:1760	Besides, the proposed chiral sensing platform can be effectively applied in real samples to detect Trp enantiomers sensitively.
33675271	6	91	theme	peak	1153:1156	arg1	2.1					1236:1238	2.1	1236:1238	2.1	1236:1238	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	6	91	theme	peak	1153:1156	arg1	ratio					1166:1170	the peak current ratio	1149:1170	the peak current ratio in the solution of l-Trp and d-Trp (ID /IL )	1149:1215	In the case of optimal conditions, the peak current ratio in the solution of l-Trp and d-Trp (ID /IL ) was observed to be 2.1 at CNT/PANI/SA/GCE by differential pulse voltammogram (DPV).
33675271	3	92	theme	multiwalled	477:487	arg1	interface					651:659	the electrochemical sensing interface	623:659	the electrochemical sensing interface	623:659	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	3	92	theme	multiwalled	477:487	arg1	nanocomposite					548:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite	455:560	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material	455:602	Then a self-assembled multiwalled carbon nanotubes/polyaniline/sodium alginate (CNT/PANI/SA) nanocomposite with chiral sites and conductive material was synthesized as the electrochemical sensing interface.
33675271	4	93	from	material	762:769	arg1	CNT/PANI/SA/GCE					810:824	CNT/PANI/SA/GCE	810:824	CNT/PANI/SA/GCE	810:824	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	4	93	from	material	762:769	arg1	electrode					799:807	a polished glassy carbon electrode	774:807	a polished glassy carbon electrode (CNT/PANI/SA/GCE)	774:825	Next, a novel electrochemical sensing interface was fabricated via modifying the as-prepared chiral material on a polished glassy carbon electrode (CNT/PANI/SA/GCE) for precisely, efficiently, and rapidly differentiation of tryptophan (Trp) enantiomers.
33675271	7	94	contain	had	1357:1359	arg2	energy					1379:1384	a greater binding energy	1361:1384	a greater binding energy	1361:1384	UV-visible spectroscopy further showed that CNT/PANI/SA had a greater binding energy to l-Trp.
33675271	7	94	contain	had	1357:1359	arg1	CNT/PANI/SA					1345:1355	CNT/PANI/SA	1345:1355	CNT/PANI/SA	1345:1355	UV-visible spectroscopy further showed that CNT/PANI/SA had a greater binding energy to l-Trp.
33675271	10	95	theme	Trp	1772:1774	arg1	enantiomers					1776:1786	Trp enantiomers	1772:1786	Trp enantiomers	1772:1786	Besides, the proposed chiral sensing platform can be effectively applied in real samples to detect Trp enantiomers sensitively.
33675271	1	96	theme	molecules	260:268	arg1	identification					223:236	identification	223:236	identification of optical amino acid molecules	223:268	Due to the crucial role of amino acids in life sciences and pharmaceutics, identification of optical amino acid molecules is of great significance.
33255075	3	0	theme	molecular	783:791	arg1	structure					793:801	the molecular structure	779:801	the molecular structure on the surface of Ag NCs	779:826	This nanogel displays an amplified luminescence via strong matrix-ligand coordination between thiolate ligands and chitosan matrix to rigidify the molecular structure on the surface of Ag NCs.
33255075	1	1	theme	desired	277:283	arg1	agents					154:159	Multifunctional theranostic agents	126:159	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection	126:267	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	1	1	theme	desired	277:283	arg1	medicine					292:299	the desired future medicine	273:299	the desired future medicine for infectious diseases	273:323	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	0	2	theme	bactericidal	85:96	arg1	agent					98:102	bactericidal agent	85:102	bactericidal agent	85:102	Self-assembled nanogels of luminescent thiolated silver nanoclusters and chitosan as bactericidal agent and bacterial sensor.
33255075	1	3	theme	good	182:185	arg1	biocompatibility					187:202	good biocompatibility	182:202	good biocompatibility	182:202	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	1	4	theme	future	285:290	arg1	agents					154:159	Multifunctional theranostic agents	126:159	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection	126:267	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	1	4	theme	future	285:290	arg1	medicine					292:299	the desired future medicine	273:299	the desired future medicine for infectious diseases	273:323	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	0	5	theme	bacterial	108:116	arg1	sensor					118:123	bacterial sensor	108:123	bacterial sensor	108:123	Self-assembled nanogels of luminescent thiolated silver nanoclusters and chitosan as bactericidal agent and bacterial sensor.
33255075	3	6	theme	chitosan	751:758	arg1	matrix					760:765	chitosan matrix	751:765	chitosan matrix	751:765	This nanogel displays an amplified luminescence via strong matrix-ligand coordination between thiolate ligands and chitosan matrix to rigidify the molecular structure on the surface of Ag NCs.
33255075	6	7	theme	practical	1242:1250	arg1	applications					1252:1263	practical applications	1242:1263	practical applications as the theranostic nanomedicines	1242:1296	This work provides a new strategy in designing multifunctional theranostic agents and this new composite Ag NC nanogel holds great promise for practical applications as the theranostic nanomedicines.
33255075	1	8	theme	such	375:378	arg1	nanocomposites					396:409	such multifunctional nanocomposites	375:409	such multifunctional nanocomposites in a single entity	375:428	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	6	9	theme	composite	1194:1202	arg1	nanogel					1210:1216	this new composite Ag NC nanogel	1185:1216	this new composite Ag NC nanogel	1185:1216	This work provides a new strategy in designing multifunctional theranostic agents and this new composite Ag NC nanogel holds great promise for practical applications as the theranostic nanomedicines.
33255075	2	10	dep	biocompatible	577:589	arg1	luminescent					612:622	luminescent	612:622	luminescent	612:622	Herein, self-assembled nanogels of thiolated silver nanoclusters (Ag NCs) and chitosan was designed and synthesized, which combines the desirable biocompatible, targeting specific, luminescent properties.
33255075	2	10	dep	biocompatible	577:589	arg1	specific					602:609	specific	602:609	specific	602:609	Herein, self-assembled nanogels of thiolated silver nanoclusters (Ag NCs) and chitosan was designed and synthesized, which combines the desirable biocompatible, targeting specific, luminescent properties.
33255075	1	11	theme	multifunctional	380:394	arg1	nanocomposites					396:409	such multifunctional nanocomposites	375:409	such multifunctional nanocomposites in a single entity	375:428	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	1	12	with	agents	154:159	arg1	features					170:177	the features	166:177	the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection	166:267	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	6	13	theme	new	1120:1122	arg1	strategy					1124:1131	a new strategy	1118:1131	a new strategy in designing multifunctional theranostic agents	1118:1179	This work provides a new strategy in designing multifunctional theranostic agents and this new composite Ag NC nanogel holds great promise for practical applications as the theranostic nanomedicines.
33255075	1	14	theme	biocompatibility	187:202	arg1	features					170:177	the features	166:177	the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection	166:267	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	1	15	theme	nanocomposites	396:409	arg1	design					365:370	the design	361:370	the design of such multifunctional nanocomposites in a single entity	361:428	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	1	16	from	design	365:370	arg1	entity					423:428	a single entity	414:428	a single entity	414:428	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	2	17	theme	silver	476:481	arg1	nanoclusters					483:494	thiolated silver nanoclusters	466:494	thiolated silver nanoclusters (Ag NCs)	466:503	Herein, self-assembled nanogels of thiolated silver nanoclusters (Ag NCs) and chitosan was designed and synthesized, which combines the desirable biocompatible, targeting specific, luminescent properties.
33255075	2	17	theme	silver	476:481	arg1	NCs					500:502	Ag NCs	497:502	Ag NCs	497:502	Herein, self-assembled nanogels of thiolated silver nanoclusters (Ag NCs) and chitosan was designed and synthesized, which combines the desirable biocompatible, targeting specific, luminescent properties.
33255075	5	18	from	binding	1062:1068	arg1	nanogels					1089:1096	the fluorescent nanogels	1073:1096	the fluorescent nanogels	1073:1096	Furthermore, a bacterial detection system was developed based on the bacterial binding on the fluorescent nanogels.
33255075	3	19	theme	Ag	821:822	arg1	NCs					824:826	Ag NCs	821:826	Ag NCs	821:826	This nanogel displays an amplified luminescence via strong matrix-ligand coordination between thiolate ligands and chitosan matrix to rigidify the molecular structure on the surface of Ag NCs.
33255075	1	20	from	nanocomposites	396:409	arg1	entity					423:428	a single entity	414:428	a single entity	414:428	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	4	21	theme	stronger	929:936	arg1	activity					938:945	approximately >10-fold stronger activity	906:945	approximately >10-fold stronger activity	906:945	Concomitantly, this nanogel exhibits exceptional bactericidal activity, with approximately >10-fold stronger activity compared to its counterpart Ag NCs.
33255075	5	22	theme	detection	1008:1016	arg1	system					1018:1023	a bacterial detection system	996:1023	a bacterial detection system	996:1023	Furthermore, a bacterial detection system was developed based on the bacterial binding on the fluorescent nanogels.
33255075	1	23	theme	long-term	205:213	arg1	efficacy					229:236	long-term antibacterial efficacy	205:236	long-term antibacterial efficacy	205:236	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	0	24	theme	Self-assembled	0:13	arg1	nanogels					15:22	Self-assembled nanogels	0:22	Self-assembled nanogels of luminescent	0:37	Self-assembled nanogels of luminescent thiolated silver nanoclusters and chitosan as bactericidal agent and bacterial sensor.
33255075	1	25	theme	infectious	305:314	arg1	diseases					316:323	infectious diseases	305:323	infectious diseases	305:323	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	3	26	theme	thiolate	730:737	arg1	ligands					739:745	thiolate ligands	730:745	thiolate ligands	730:745	This nanogel displays an amplified luminescence via strong matrix-ligand coordination between thiolate ligands and chitosan matrix to rigidify the molecular structure on the surface of Ag NCs.
33255075	1	27	theme	antibacterial	215:227	arg1	efficacy					229:236	long-term antibacterial efficacy	205:236	long-term antibacterial efficacy	205:236	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	0	28	theme	luminescent	27:37	arg1	nanogels					15:22	Self-assembled nanogels	0:22	Self-assembled nanogels of luminescent	0:37	Self-assembled nanogels of luminescent thiolated silver nanoclusters and chitosan as bactericidal agent and bacterial sensor.
33255075	2	29	theme	biocompatible	577:589	arg1	properties					624:633	the desirable biocompatible, targeting specific, luminescent properties	563:633	the desirable biocompatible, targeting specific, luminescent properties	563:633	Herein, self-assembled nanogels of thiolated silver nanoclusters (Ag NCs) and chitosan was designed and synthesized, which combines the desirable biocompatible, targeting specific, luminescent properties.
33255075	6	30	theme	great	1224:1228	arg1	promise					1230:1236	great promise	1224:1236	great promise for practical applications as the theranostic nanomedicines	1224:1296	This work provides a new strategy in designing multifunctional theranostic agents and this new composite Ag NC nanogel holds great promise for practical applications as the theranostic nanomedicines.
33255075	1	31	theme	efficacy	229:236	arg1	features					170:177	the features	166:177	the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection	166:267	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	3	32	from	structure	793:801	arg1	surface					810:816	the surface	806:816	the surface of Ag NCs	806:826	This nanogel displays an amplified luminescence via strong matrix-ligand coordination between thiolate ligands and chitosan matrix to rigidify the molecular structure on the surface of Ag NCs.
33255075	2	33	theme	desirable	567:575	arg1	properties					624:633	the desirable biocompatible, targeting specific, luminescent properties	563:633	the desirable biocompatible, targeting specific, luminescent properties	563:633	Herein, self-assembled nanogels of thiolated silver nanoclusters (Ag NCs) and chitosan was designed and synthesized, which combines the desirable biocompatible, targeting specific, luminescent properties.
33255075	3	34	theme	strong	688:693	arg1	coordination					709:720	strong matrix-ligand coordination	688:720	strong matrix-ligand coordination between thiolate ligands and chitosan matrix to rigidify the molecular structure on the surface of Ag NCs	688:826	This nanogel displays an amplified luminescence via strong matrix-ligand coordination between thiolate ligands and chitosan matrix to rigidify the molecular structure on the surface of Ag NCs.
33255075	2	35	theme	self-assembled	439:452	arg1	nanogels					454:461	self-assembled nanogels	439:461	self-assembled nanogels of thiolated silver nanoclusters (Ag NCs)	439:503	Herein, self-assembled nanogels of thiolated silver nanoclusters (Ag NCs) and chitosan was designed and synthesized, which combines the desirable biocompatible, targeting specific, luminescent properties.
33255075	0	36	theme	silver	49:54	arg1	nanoclusters					56:67	silver nanoclusters	49:67	silver nanoclusters	49:67	Self-assembled nanogels of luminescent thiolated silver nanoclusters and chitosan as bactericidal agent and bacterial sensor.
33255075	3	37	theme	matrix-ligand	695:707	arg1	coordination					709:720	strong matrix-ligand coordination	688:720	strong matrix-ligand coordination between thiolate ligands and chitosan matrix to rigidify the molecular structure on the surface of Ag NCs	688:826	This nanogel displays an amplified luminescence via strong matrix-ligand coordination between thiolate ligands and chitosan matrix to rigidify the molecular structure on the surface of Ag NCs.
33255075	1	38	theme	single	416:421	arg1	entity					423:428	a single entity	414:428	a single entity	414:428	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	4	39	theme	bactericidal	878:889	arg1	activity					891:898	exceptional bactericidal activity	866:898	exceptional bactericidal activity	866:898	Concomitantly, this nanogel exhibits exceptional bactericidal activity, with approximately >10-fold stronger activity compared to its counterpart Ag NCs.
33255075	6	40	theme	theranostic	1272:1282	arg1	nanomedicines					1284:1296	the theranostic nanomedicines	1268:1296	the theranostic nanomedicines	1268:1296	This work provides a new strategy in designing multifunctional theranostic agents and this new composite Ag NC nanogel holds great promise for practical applications as the theranostic nanomedicines.
33255075	6	41	theme	theranostic	1162:1172	arg1	agents					1174:1179	multifunctional theranostic agents	1146:1179	multifunctional theranostic agents	1146:1179	This work provides a new strategy in designing multifunctional theranostic agents and this new composite Ag NC nanogel holds great promise for practical applications as the theranostic nanomedicines.
33255075	2	42	theme	thiolated	466:474	arg1	nanoclusters					483:494	thiolated silver nanoclusters	466:494	thiolated silver nanoclusters (Ag NCs)	466:503	Herein, self-assembled nanogels of thiolated silver nanoclusters (Ag NCs) and chitosan was designed and synthesized, which combines the desirable biocompatible, targeting specific, luminescent properties.
33255075	2	42	theme	thiolated	466:474	arg1	NCs					500:502	Ag NCs	497:502	Ag NCs	497:502	Herein, self-assembled nanogels of thiolated silver nanoclusters (Ag NCs) and chitosan was designed and synthesized, which combines the desirable biocompatible, targeting specific, luminescent properties.
33255075	1	43	theme	rapid	243:247	arg1	detection					259:267	rapid bacterial detection	243:267	rapid bacterial detection	243:267	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	2	44	theme	Ag	497:498	arg1	nanoclusters					483:494	thiolated silver nanoclusters	466:494	thiolated silver nanoclusters (Ag NCs)	466:503	Herein, self-assembled nanogels of thiolated silver nanoclusters (Ag NCs) and chitosan was designed and synthesized, which combines the desirable biocompatible, targeting specific, luminescent properties.
33255075	2	44	theme	Ag	497:498	arg1	NCs					500:502	Ag NCs	497:502	Ag NCs	497:502	Herein, self-assembled nanogels of thiolated silver nanoclusters (Ag NCs) and chitosan was designed and synthesized, which combines the desirable biocompatible, targeting specific, luminescent properties.
33255075	1	45	from	entity	423:428	arg1	design					365:370	the design	361:370	the design of such multifunctional nanocomposites in a single entity	361:428	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	4	46	theme	Ag	975:976	arg1	NCs					978:980	its counterpart Ag NCs	959:980	its counterpart Ag NCs	959:980	Concomitantly, this nanogel exhibits exceptional bactericidal activity, with approximately >10-fold stronger activity compared to its counterpart Ag NCs.
33255075	6	47	theme	NC	1207:1208	arg1	nanogel					1210:1216	this new composite Ag NC nanogel	1185:1216	this new composite Ag NC nanogel	1185:1216	This work provides a new strategy in designing multifunctional theranostic agents and this new composite Ag NC nanogel holds great promise for practical applications as the theranostic nanomedicines.
33255075	1	48	theme	Multifunctional	126:140	arg1	agents					154:159	Multifunctional theranostic agents	126:159	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection	126:267	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	1	48	theme	Multifunctional	126:140	arg1	medicine					292:299	the desired future medicine	273:299	the desired future medicine for infectious diseases	273:323	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	1	49	theme	huge	342:345	arg1	challenges					347:356	huge challenges	342:356	huge challenges	342:356	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	4	50	theme	counterpart	963:973	arg1	NCs					978:980	its counterpart Ag NCs	959:980	its counterpart Ag NCs	959:980	Concomitantly, this nanogel exhibits exceptional bactericidal activity, with approximately >10-fold stronger activity compared to its counterpart Ag NCs.
33255075	1	51	dep	medicine	292:299	arg1	poses					336:340	poses	336:340	poses huge challenges on the design of such multifunctional nanocomposites in a single entity	336:428	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	1	52	theme	theranostic	142:152	arg1	agents					154:159	Multifunctional theranostic agents	126:159	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection	126:267	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	1	52	theme	theranostic	142:152	arg1	medicine					292:299	the desired future medicine	273:299	the desired future medicine for infectious diseases	273:323	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	3	53	theme	NCs	824:826	arg1	surface					810:816	the surface	806:816	the surface of Ag NCs	806:826	This nanogel displays an amplified luminescence via strong matrix-ligand coordination between thiolate ligands and chitosan matrix to rigidify the molecular structure on the surface of Ag NCs.
33255075	4	54	theme	exceptional	866:876	arg1	activity					891:898	exceptional bactericidal activity	866:898	exceptional bactericidal activity	866:898	Concomitantly, this nanogel exhibits exceptional bactericidal activity, with approximately >10-fold stronger activity compared to its counterpart Ag NCs.
33255075	6	55	theme	Ag	1204:1205	arg1	nanogel					1210:1216	this new composite Ag NC nanogel	1185:1216	this new composite Ag NC nanogel	1185:1216	This work provides a new strategy in designing multifunctional theranostic agents and this new composite Ag NC nanogel holds great promise for practical applications as the theranostic nanomedicines.
33255075	1	56	theme	bacterial	249:257	arg1	detection					259:267	rapid bacterial detection	243:267	rapid bacterial detection	243:267	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	5	57	theme	bacterial	1052:1060	arg1	binding					1062:1068	the bacterial binding	1048:1068	the bacterial binding on the fluorescent nanogels	1048:1096	Furthermore, a bacterial detection system was developed based on the bacterial binding on the fluorescent nanogels.
33255075	3	58	theme	amplified	661:669	arg1	luminescence					671:682	an amplified luminescence	658:682	an amplified luminescence	658:682	This nanogel displays an amplified luminescence via strong matrix-ligand coordination between thiolate ligands and chitosan matrix to rigidify the molecular structure on the surface of Ag NCs.
33255075	5	59	theme	bacterial	998:1006	arg1	system					1018:1023	a bacterial detection system	996:1023	a bacterial detection system	996:1023	Furthermore, a bacterial detection system was developed based on the bacterial binding on the fluorescent nanogels.
33255075	1	60	theme	detection	259:267	arg1	features					170:177	the features	166:177	the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection	166:267	Multifunctional theranostic agents with the features of good biocompatibility, long-term antibacterial efficacy, and rapid bacterial detection are the desired future medicine for infectious diseases, but which poses huge challenges on the design of such multifunctional nanocomposites in a single entity.
33255075	6	61	theme	new	1190:1192	arg1	nanogel					1210:1216	this new composite Ag NC nanogel	1185:1216	this new composite Ag NC nanogel	1185:1216	This work provides a new strategy in designing multifunctional theranostic agents and this new composite Ag NC nanogel holds great promise for practical applications as the theranostic nanomedicines.
33255075	6	62	theme	multifunctional	1146:1160	arg1	agents					1174:1179	multifunctional theranostic agents	1146:1179	multifunctional theranostic agents	1146:1179	This work provides a new strategy in designing multifunctional theranostic agents and this new composite Ag NC nanogel holds great promise for practical applications as the theranostic nanomedicines.
33255075	5	63	theme	fluorescent	1077:1087	arg1	nanogels					1089:1096	the fluorescent nanogels	1073:1096	the fluorescent nanogels	1073:1096	Furthermore, a bacterial detection system was developed based on the bacterial binding on the fluorescent nanogels.
33255075	2	64	theme	nanoclusters	483:494	arg1	chitosan					509:516	chitosan	509:516	chitosan	509:516	Herein, self-assembled nanogels of thiolated silver nanoclusters (Ag NCs) and chitosan was designed and synthesized, which combines the desirable biocompatible, targeting specific, luminescent properties.
33255075	2	64	theme	nanoclusters	483:494	arg1	nanogels					454:461	self-assembled nanogels	439:461	self-assembled nanogels of thiolated silver nanoclusters (Ag NCs)	439:503	Herein, self-assembled nanogels of thiolated silver nanoclusters (Ag NCs) and chitosan was designed and synthesized, which combines the desirable biocompatible, targeting specific, luminescent properties.
34662648	0	0	from	considerations	15:28	arg1	blends					48:53	ternary powder blends	33:53	ternary powder blends for inhalation	33:68	Surface energy considerations in ternary powder blends for inhalation.
34662648	4	1	from	energies	531:538	arg1	performance					610:620	the aerodynamic performance	594:620	the aerodynamic performance of the respective ternary blends	594:653	The first part of this study aims at comparing the surface energies of lactose fines and their corresponding influence on the aerodynamic performance of the respective ternary blends.
34662648	4	2	theme	aerodynamic	598:608	arg1	performance					610:620	the aerodynamic performance	594:620	the aerodynamic performance of the respective ternary blends	594:653	The first part of this study aims at comparing the surface energies of lactose fines and their corresponding influence on the aerodynamic performance of the respective ternary blends.
34662648	6	3	theme	different	944:952	arg1	energies					962:969	different surface energies	944:969	different surface energies	944:969	It demonstrates the crucial influence of adhesion properties of fines, based on different surface energies.
34662648	7	4	theme	properties	1123:1132	arg1	influence					1102:1110	the negligible influence	1087:1110	the negligible influence of carrier properties	1087:1132	Secondly, one specific fine lactose quality was used on fundamentally different lactose carriers, which highlights the negligible influence of carrier properties if extrinsic fines are preferentially capable of excipient-drug interactions.
34662648	7	5	theme	fine	995:998	arg1	quality					1008:1014	one specific fine lactose quality	982:1014	one specific fine lactose quality	982:1014	Secondly, one specific fine lactose quality was used on fundamentally different lactose carriers, which highlights the negligible influence of carrier properties if extrinsic fines are preferentially capable of excipient-drug interactions.
34662648	1	6	theme	respiratory	150:160	arg1	delivery					167:174	respiratory drug delivery	150:174	respiratory drug delivery	150:174	The need for optimisation of DPI formulations is a main research motivation in respiratory drug delivery.
34662648	4	7	theme	first	476:480	arg1	part					482:485	The first part	472:485	The first part of this study	472:499	The first part of this study aims at comparing the surface energies of lactose fines and their corresponding influence on the aerodynamic performance of the respective ternary blends.
34662648	3	8	theme	wide	363:366	arg1	range					368:372	a wide range	361:372	a wide range of solid-state characteristics to understand their mechanism and classify influencing parameters	361:469	The addition of extrinsic fine excipients is extensively discussed since decades, supported by a wide range of solid-state characteristics to understand their mechanism and classify influencing parameters.
34662648	4	9	theme	surface	523:529	arg1	energies					531:538	the surface energies	519:538	the surface energies of lactose fines	519:555	The first part of this study aims at comparing the surface energies of lactose fines and their corresponding influence on the aerodynamic performance of the respective ternary blends.
34662648	7	10	theme	lactose	1000:1006	arg1	quality					1008:1014	one specific fine lactose quality	982:1014	one specific fine lactose quality	982:1014	Secondly, one specific fine lactose quality was used on fundamentally different lactose carriers, which highlights the negligible influence of carrier properties if extrinsic fines are preferentially capable of excipient-drug interactions.
34662648	7	11	used	used	1020:1023	arg2	quality					1008:1014	one specific fine lactose quality	982:1014	one specific fine lactose quality	982:1014	Secondly, one specific fine lactose quality was used on fundamentally different lactose carriers, which highlights the negligible influence of carrier properties if extrinsic fines are preferentially capable of excipient-drug interactions.
34662648	4	12	theme	study	495:499	arg1	part					482:485	The first part	472:485	The first part of this study	472:499	The first part of this study aims at comparing the surface energies of lactose fines and their corresponding influence on the aerodynamic performance of the respective ternary blends.
34662648	5	13	theme	varying	699:705	arg1	origins					707:713	varying origins	699:713	varying origins	699:713	Five different fine lactose qualities with varying origins were used, which were distinguishable in terms of surface energy, but comparable regarding particle size, moisture content and chemical composition.
34662648	5	14	theme	surface	765:771	arg1	energy					773:778	surface energy	765:778	surface energy	765:778	Five different fine lactose qualities with varying origins were used, which were distinguishable in terms of surface energy, but comparable regarding particle size, moisture content and chemical composition.
34662648	5	15	used	used	720:723	arg2	qualities					684:692	Five different fine lactose qualities	656:692	Five different fine lactose qualities with varying origins	656:713	Five different fine lactose qualities with varying origins were used, which were distinguishable in terms of surface energy, but comparable regarding particle size, moisture content and chemical composition.
34662648	7	16	theme	extrinsic	1137:1145	arg1	fines					1147:1151	extrinsic fines	1137:1151	extrinsic fines	1137:1151	Secondly, one specific fine lactose quality was used on fundamentally different lactose carriers, which highlights the negligible influence of carrier properties if extrinsic fines are preferentially capable of excipient-drug interactions.
34662648	1	17	from	motivation	136:145	arg1	delivery					167:174	respiratory drug delivery	150:174	respiratory drug delivery	150:174	The need for optimisation of DPI formulations is a main research motivation in respiratory drug delivery.
34662648	1	18	theme	drug	162:165	arg1	delivery					167:174	respiratory drug delivery	150:174	respiratory drug delivery	150:174	The need for optimisation of DPI formulations is a main research motivation in respiratory drug delivery.
34662648	3	19	dep	discussed	323:331	arg1	supported					348:356	supported	348:356	supported by a wide range of solid-state characteristics to understand their mechanism and classify influencing parameters	348:469	The addition of extrinsic fine excipients is extensively discussed since decades, supported by a wide range of solid-state characteristics to understand their mechanism and classify influencing parameters.
34662648	5	20	theme	lactose	676:682	arg1	qualities					684:692	Five different fine lactose qualities	656:692	Five different fine lactose qualities with varying origins	656:713	Five different fine lactose qualities with varying origins were used, which were distinguishable in terms of surface energy, but comparable regarding particle size, moisture content and chemical composition.
34662648	5	21	theme	particle	806:813	arg1	size					815:818	particle size	806:818	particle size	806:818	Five different fine lactose qualities with varying origins were used, which were distinguishable in terms of surface energy, but comparable regarding particle size, moisture content and chemical composition.
34662648	7	22	theme	carrier	1115:1121	arg1	properties					1123:1132	carrier properties	1115:1132	carrier properties	1115:1132	Secondly, one specific fine lactose quality was used on fundamentally different lactose carriers, which highlights the negligible influence of carrier properties if extrinsic fines are preferentially capable of excipient-drug interactions.
34662648	4	23	from	influence	581:589	arg1	performance					610:620	the aerodynamic performance	594:620	the aerodynamic performance of the respective ternary blends	594:653	The first part of this study aims at comparing the surface energies of lactose fines and their corresponding influence on the aerodynamic performance of the respective ternary blends.
34662648	0	24	theme	energy	8:13	arg1	considerations					15:28	Surface energy considerations	0:28	Surface energy considerations in ternary powder blends for inhalation	0:68	Surface energy considerations in ternary powder blends for inhalation.
34662648	6	25	theme	properties	914:923	arg1	influence					892:900	the crucial influence	880:900	the crucial influence	880:900	It demonstrates the crucial influence of adhesion properties of fines, based on different surface energies.
34662648	5	26	theme	different	661:669	arg1	qualities					684:692	Five different fine lactose qualities	656:692	Five different fine lactose qualities with varying origins	656:713	Five different fine lactose qualities with varying origins were used, which were distinguishable in terms of surface energy, but comparable regarding particle size, moisture content and chemical composition.
34662648	6	27	theme	fines	928:932	arg1	properties					914:923	adhesion properties	905:923	adhesion properties of fines	905:932	It demonstrates the crucial influence of adhesion properties of fines, based on different surface energies.
34662648	0	28	theme	Surface	0:6	arg1	considerations					15:28	Surface energy considerations	0:28	Surface energy considerations in ternary powder blends for inhalation	0:68	Surface energy considerations in ternary powder blends for inhalation.
34662648	4	29	theme	corresponding	567:579	arg1	influence					581:589	their corresponding influence	561:589	their corresponding influence on the aerodynamic performance of the respective ternary blends	561:653	The first part of this study aims at comparing the surface energies of lactose fines and their corresponding influence on the aerodynamic performance of the respective ternary blends.
34662648	5	30	theme	fine	671:674	arg1	qualities					684:692	Five different fine lactose qualities	656:692	Five different fine lactose qualities with varying origins	656:713	Five different fine lactose qualities with varying origins were used, which were distinguishable in terms of surface energy, but comparable regarding particle size, moisture content and chemical composition.
34662648	3	31	theme	influencing	448:458	arg1	parameters					460:469	influencing parameters	448:469	influencing parameters	448:469	The addition of extrinsic fine excipients is extensively discussed since decades, supported by a wide range of solid-state characteristics to understand their mechanism and classify influencing parameters.
34662648	5	32	theme	chemical	842:849	arg1	composition					851:861	chemical composition	842:861	chemical composition	842:861	Five different fine lactose qualities with varying origins were used, which were distinguishable in terms of surface energy, but comparable regarding particle size, moisture content and chemical composition.
34662648	3	33	theme	extrinsic	282:290	arg1	excipients					297:306	extrinsic fine excipients	282:306	extrinsic fine excipients	282:306	The addition of extrinsic fine excipients is extensively discussed since decades, supported by a wide range of solid-state characteristics to understand their mechanism and classify influencing parameters.
34662648	7	34	theme	specific	986:993	arg1	quality					1008:1014	one specific fine lactose quality	982:1014	one specific fine lactose quality	982:1014	Secondly, one specific fine lactose quality was used on fundamentally different lactose carriers, which highlights the negligible influence of carrier properties if extrinsic fines are preferentially capable of excipient-drug interactions.
34662648	3	35	theme	solid-state	377:387	arg1	characteristics					389:403	solid-state characteristics	377:403	solid-state characteristics	377:403	The addition of extrinsic fine excipients is extensively discussed since decades, supported by a wide range of solid-state characteristics to understand their mechanism and classify influencing parameters.
34662648	3	36	theme	fine	292:295	arg1	excipients					297:306	extrinsic fine excipients	282:306	extrinsic fine excipients	282:306	The addition of extrinsic fine excipients is extensively discussed since decades, supported by a wide range of solid-state characteristics to understand their mechanism and classify influencing parameters.
34662648	2	37	theme	Well-established	177:192	arg1	formulations					194:205	Well-established formulations	177:205	Well-established formulations like carrier-based blends	177:231	Well-established formulations like carrier-based blends still show a lack of efficiency.
34662648	1	38	theme	DPI	100:102	arg1	formulations					104:115	DPI formulations	100:115	DPI formulations	100:115	The need for optimisation of DPI formulations is a main research motivation in respiratory drug delivery.
34662648	0	39	theme	powder	41:46	arg1	blends					48:53	ternary powder blends	33:53	ternary powder blends for inhalation	33:68	Surface energy considerations in ternary powder blends for inhalation.
34662648	7	40	theme	negligible	1091:1100	arg1	influence					1102:1110	the negligible influence	1087:1110	the negligible influence of carrier properties	1087:1132	Secondly, one specific fine lactose quality was used on fundamentally different lactose carriers, which highlights the negligible influence of carrier properties if extrinsic fines are preferentially capable of excipient-drug interactions.
34662648	0	41	theme	ternary	33:39	arg1	blends					48:53	ternary powder blends	33:53	ternary powder blends for inhalation	33:68	Surface energy considerations in ternary powder blends for inhalation.
34662648	4	42	theme	lactose	543:549	arg1	fines					551:555	lactose fines	543:555	lactose fines	543:555	The first part of this study aims at comparing the surface energies of lactose fines and their corresponding influence on the aerodynamic performance of the respective ternary blends.
34662648	5	43	from	terms	756:760	arg1	distinguishable					737:751	distinguishable	737:751	distinguishable	737:751	Five different fine lactose qualities with varying origins were used, which were distinguishable in terms of surface energy, but comparable regarding particle size, moisture content and chemical composition.
34662648	5	44	from	distinguishable	737:751	arg1	terms					756:760	terms	756:760	terms of surface energy	756:778	Five different fine lactose qualities with varying origins were used, which were distinguishable in terms of surface energy, but comparable regarding particle size, moisture content and chemical composition.
34662648	5	45	theme	energy	773:778	arg1	terms					756:760	terms	756:760	terms of surface energy	756:778	Five different fine lactose qualities with varying origins were used, which were distinguishable in terms of surface energy, but comparable regarding particle size, moisture content and chemical composition.
34662648	7	46	theme	excipient-drug	1183:1196	arg1	interactions					1198:1209	excipient-drug interactions	1183:1209	excipient-drug interactions	1183:1209	Secondly, one specific fine lactose quality was used on fundamentally different lactose carriers, which highlights the negligible influence of carrier properties if extrinsic fines are preferentially capable of excipient-drug interactions.
34662648	6	47	theme	crucial	884:890	arg1	influence					892:900	the crucial influence	880:900	the crucial influence	880:900	It demonstrates the crucial influence of adhesion properties of fines, based on different surface energies.
34662648	6	48	theme	adhesion	905:912	arg1	properties					914:923	adhesion properties	905:923	adhesion properties of fines	905:932	It demonstrates the crucial influence of adhesion properties of fines, based on different surface energies.
34662648	1	49	theme	formulations	104:115	arg1	optimisation					84:95	optimisation	84:95	optimisation of DPI formulations	84:115	The need for optimisation of DPI formulations is a main research motivation in respiratory drug delivery.
34662648	5	50	theme	moisture	821:828	arg1	content					830:836	moisture content	821:836	moisture content	821:836	Five different fine lactose qualities with varying origins were used, which were distinguishable in terms of surface energy, but comparable regarding particle size, moisture content and chemical composition.
34662648	4	51	theme	fines	551:555	arg1	influence					581:589	their corresponding influence	561:589	their corresponding influence on the aerodynamic performance of the respective ternary blends	561:653	The first part of this study aims at comparing the surface energies of lactose fines and their corresponding influence on the aerodynamic performance of the respective ternary blends.
34662648	4	51	theme	fines	551:555	arg1	energies					531:538	the surface energies	519:538	the surface energies of lactose fines	519:555	The first part of this study aims at comparing the surface energies of lactose fines and their corresponding influence on the aerodynamic performance of the respective ternary blends.
34662648	3	52	theme	excipients	297:306	arg1	addition					270:277	The addition	266:277	The addition of extrinsic fine excipients	266:306	The addition of extrinsic fine excipients is extensively discussed since decades, supported by a wide range of solid-state characteristics to understand their mechanism and classify influencing parameters.
34662648	2	53	theme	carrier-based	212:224	arg1	blends					226:231	carrier-based blends	212:231	carrier-based blends	212:231	Well-established formulations like carrier-based blends still show a lack of efficiency.
34662648	7	54	theme	interactions	1198:1209	arg1	capable					1172:1178	capable	1172:1178	capable	1172:1178	Secondly, one specific fine lactose quality was used on fundamentally different lactose carriers, which highlights the negligible influence of carrier properties if extrinsic fines are preferentially capable of excipient-drug interactions.
34662648	7	55	theme	different	1042:1050	arg1	carriers					1060:1067	fundamentally different lactose carriers	1028:1067	fundamentally different lactose carriers	1028:1067	Secondly, one specific fine lactose quality was used on fundamentally different lactose carriers, which highlights the negligible influence of carrier properties if extrinsic fines are preferentially capable of excipient-drug interactions.
34662648	5	56	with	qualities	684:692	arg1	origins					707:713	varying origins	699:713	varying origins	699:713	Five different fine lactose qualities with varying origins were used, which were distinguishable in terms of surface energy, but comparable regarding particle size, moisture content and chemical composition.
34662648	4	57	theme	respective	629:638	arg1	blends					648:653	the respective ternary blends	625:653	the respective ternary blends	625:653	The first part of this study aims at comparing the surface energies of lactose fines and their corresponding influence on the aerodynamic performance of the respective ternary blends.
34662648	7	58	theme	lactose	1052:1058	arg1	carriers					1060:1067	fundamentally different lactose carriers	1028:1067	fundamentally different lactose carriers	1028:1067	Secondly, one specific fine lactose quality was used on fundamentally different lactose carriers, which highlights the negligible influence of carrier properties if extrinsic fines are preferentially capable of excipient-drug interactions.
34662648	1	59	theme	main	122:125	arg1	motivation					136:145	a main research motivation	120:145	a main research motivation in respiratory drug delivery	120:174	The need for optimisation of DPI formulations is a main research motivation in respiratory drug delivery.
34662648	1	59	theme	main	122:125	arg1	need					75:78	The need	71:78	The need for optimisation of DPI formulations	71:115	The need for optimisation of DPI formulations is a main research motivation in respiratory drug delivery.
34662648	2	60	theme	efficiency	254:263	arg1	lack					246:249	a lack	244:249	a lack of efficiency	244:263	Well-established formulations like carrier-based blends still show a lack of efficiency.
34662648	1	61	theme	research	127:134	arg1	motivation					136:145	a main research motivation	120:145	a main research motivation in respiratory drug delivery	120:174	The need for optimisation of DPI formulations is a main research motivation in respiratory drug delivery.
34662648	1	61	theme	research	127:134	arg1	need					75:78	The need	71:78	The need for optimisation of DPI formulations	71:115	The need for optimisation of DPI formulations is a main research motivation in respiratory drug delivery.
34662648	4	62	theme	blends	648:653	arg1	performance					610:620	the aerodynamic performance	594:620	the aerodynamic performance of the respective ternary blends	594:653	The first part of this study aims at comparing the surface energies of lactose fines and their corresponding influence on the aerodynamic performance of the respective ternary blends.
34662648	6	63	theme	surface	954:960	arg1	energies					962:969	different surface energies	944:969	different surface energies	944:969	It demonstrates the crucial influence of adhesion properties of fines, based on different surface energies.
34662648	3	64	theme	characteristics	389:403	arg1	range					368:372	a wide range	361:372	a wide range of solid-state characteristics to understand their mechanism and classify influencing parameters	361:469	The addition of extrinsic fine excipients is extensively discussed since decades, supported by a wide range of solid-state characteristics to understand their mechanism and classify influencing parameters.
34662648	4	65	theme	ternary	640:646	arg1	blends					648:653	the respective ternary blends	625:653	the respective ternary blends	625:653	The first part of this study aims at comparing the surface energies of lactose fines and their corresponding influence on the aerodynamic performance of the respective ternary blends.
33481770	2	0	theme	mL	561:562	arg1	mL					561:562	50 mg/1 mL	553:562	50 mg/1 mL	553:562	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	0	theme	mL	561:562	arg1	mL					578:579	100 mg/1 mL	569:579	100 mg/1 mL	569:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	0	theme	mL	561:562	arg1	mL					537:538	0 mg/1 mL	530:538	0 mg/1 mL	530:538	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	0	theme	mL	561:562	arg1	mL					549:550	25 mg/1 mL	541:550	25 mg/1 mL	541:550	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	0	theme	mL	561:562	arg1	amounts					519:525	amounts	519:525	amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	519:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	7	1	theme	ADBM	1187:1190	arg1	cytotoxicity					1171:1182	No cytotoxicity	1168:1182	No cytotoxicity of ADBM or alginate on mesenchymal stem cells (MSCs)	1168:1235	No cytotoxicity of ADBM or alginate on mesenchymal stem cells (MSCs) was observed.
33481770	4	2	theme	macro-scale	838:848	arg1	pores					850:854	macro-scale pores	838:854	macro-scale pores	838:854	RESULTS DBM particles were uniformly scattered in all composites, and macro-scale pores were omnipresent.
33481770	11	3	theme	synthetic	1802:1810	arg1	carrier					1830:1836	a synthetic alginate hydrogel carrier	1800:1836	a synthetic alginate hydrogel carrier	1800:1836	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33481770	1	4	theme	demineralized	246:258	arg1	particles					278:286	demineralized bone matrix (DBM) particles	246:286	demineralized bone matrix (DBM) particles	246:286	BACKGROUND Our objective was to explore a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes.
33481770	2	5	theme	50	553:554	arg1	mg/1					556:559	mg/1	556:559	mg/1	556:559	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	11	6	theme	tissue	1874:1879	arg1	engineering					1881:1891	bone tissue engineering	1869:1891	bone tissue engineering for bone defects	1869:1908	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33481770	1	7	theme	matrix	265:270	arg1	particles					278:286	demineralized bone matrix (DBM) particles	246:286	demineralized bone matrix (DBM) particles	246:286	BACKGROUND Our objective was to explore a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes.
33481770	2	8	theme	mg/1	573:576	arg1	mL					578:579	100 mg/1 mL	569:579	100 mg/1 mL	569:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	6	9	theme	pore	1114:1117	arg1	area					1119:1122	pore area	1114:1122	pore area	1114:1122	As the concentration of DBM particles in composites increased, degradation in collagenase and elastic modulus increased and the pore area and swelling ratio significantly decreased.
33481770	9	10	theme	composites	1604:1613	arg1	osteoinductivity					1575:1590	the osteoinductivity	1571:1590	the osteoinductivity of the ADBM composites was significantly greater than that of DBM particles	1571:1666	Evaluation of ectopic bone formation revealed the osteoinductivity of the ADBM composites was significantly greater than that of DBM particles.
33481770	9	11	theme	DBM	1654:1656	arg1	particles					1658:1666	DBM particles	1654:1666	DBM particles	1654:1666	Evaluation of ectopic bone formation revealed the osteoinductivity of the ADBM composites was significantly greater than that of DBM particles.
33481770	8	12	theme	expression	1417:1426	arg1	level					1428:1432	the mRNA expression level	1408:1432	the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I	1408:1480	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	2	13	theme	mL	537:538	arg1	mL					561:562	50 mg/1 mL	553:562	50 mg/1 mL	553:562	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	13	theme	mL	537:538	arg1	mL					578:579	100 mg/1 mL	569:579	100 mg/1 mL	569:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	13	theme	mL	537:538	arg1	mL					537:538	0 mg/1 mL	530:538	0 mg/1 mL	530:538	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	13	theme	mL	537:538	arg1	mL					549:550	25 mg/1 mL	541:550	25 mg/1 mL	541:550	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	13	theme	mL	537:538	arg1	amounts					519:525	amounts	519:525	amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	519:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	1	14	theme	alginate	192:199	arg1	system					219:224	a synthetic alginate hydrogel delivery system	180:224	a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes	180:313	BACKGROUND Our objective was to explore a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes.
33481770	2	15	theme	0	530:530	arg1	mg/1					532:535	mg/1	532:535	mg/1	532:535	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	8	16	theme	staining	1386:1393	arg1	upregulation					1332:1343	the upregulation	1328:1343	the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I	1328:1480	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	0	17	theme	Experimental	120:131	arg1	Study					133:137	An Animal Experimental Study	110:137	An Animal Experimental Study	110:137	Evaluation of Demineralized Bone Matrix Particles Delivered by Alginate Hydrogel for a Bone Graft Substitute: An Animal Experimental Study.
33481770	11	18	theme	bone	1897:1900	arg1	defects					1902:1908	bone defects	1897:1908	bone defects	1897:1908	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33481770	1	19	theme	delivery	210:217	arg1	system					219:224	a synthetic alginate hydrogel delivery system	180:224	a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes	180:313	BACKGROUND Our objective was to explore a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes.
33481770	2	20	theme	mL	549:550	arg1	mL					561:562	50 mg/1 mL	553:562	50 mg/1 mL	553:562	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	20	theme	mL	549:550	arg1	mL					578:579	100 mg/1 mL	569:579	100 mg/1 mL	569:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	20	theme	mL	549:550	arg1	mL					537:538	0 mg/1 mL	530:538	0 mg/1 mL	530:538	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	20	theme	mL	549:550	arg1	mL					549:550	25 mg/1 mL	541:550	25 mg/1 mL	541:550	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	20	theme	mL	549:550	arg1	amounts					519:525	amounts	519:525	amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	519:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	3	21	dep	in	622:623	arg1	vivo					625:628	vivo	625:628	vivo	625:628	In vitro cell culture and in vivo studies using Sprague-Dawley rats were performed to evaluate the biocompatibility and osteoinductivity of DBM-alginate (ADBM) composites.
33481770	11	22	from	approach	1857:1864	arg1	engineering					1881:1891	bone tissue engineering	1869:1891	bone tissue engineering for bone defects	1869:1908	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33481770	10	23	theme	cranial	1724:1730	arg1	model					1739:1743	a cranial defect model	1722:1743	a cranial defect model study	1722:1749	Osteoinduction of the composites was demonstrated by a cranial defect model study.
33481770	2	24	theme	25	541:542	arg1	mg/1					544:547	mg/1	544:547	mg/1	544:547	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	8	25	theme	mRNA	1412:1415	arg1	level					1428:1432	the mRNA expression level	1408:1432	the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I	1408:1480	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	3	26	theme	ADBM	750:753	arg1	composites					756:765	DBM-alginate (ADBM) composites	736:765	DBM-alginate (ADBM) composites	736:765	In vitro cell culture and in vivo studies using Sprague-Dawley rats were performed to evaluate the biocompatibility and osteoinductivity of DBM-alginate (ADBM) composites.
33481770	8	27	dep	phosphatase	1357:1367	arg1	level					1428:1432	the mRNA expression level	1408:1432	the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I	1408:1480	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	8	27	dep	phosphatase	1357:1367	arg1	activity					1395:1402	activity	1395:1402	activity	1395:1402	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	2	28	theme	powder	496:501	arg1	degradation					422:432	in vitro degradation	413:432	in vitro degradation	413:432	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	28	theme	powder	496:501	arg1	swelling					447:454	equilibrium swelling	435:454	equilibrium swelling	435:454	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	28	theme	powder	496:501	arg1	morphology					378:387	surface morphology	370:387	surface morphology	370:387	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	28	theme	powder	496:501	arg1	measurements					399:410	porosity measurements	390:410	porosity measurements	390:410	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	28	theme	powder	496:501	arg1	testing					472:478	mechanical testing	461:478	mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	461:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	8	29	theme	Cell	1251:1254	arg1	cultivation					1256:1266	Cell cultivation	1251:1266	Cell cultivation with ADBM	1251:1276	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	3	30	theme	DBM-alginate	736:747	arg1	composites					756:765	DBM-alginate (ADBM) composites	736:765	DBM-alginate (ADBM) composites	736:765	In vitro cell culture and in vivo studies using Sprague-Dawley rats were performed to evaluate the biocompatibility and osteoinductivity of DBM-alginate (ADBM) composites.
33481770	0	31	theme	Alginate	63:70	arg1	Hydrogel					72:79	Alginate Hydrogel	63:79	Alginate Hydrogel for a Bone Graft	63:96	Evaluation of Demineralized Bone Matrix Particles Delivered by Alginate Hydrogel for a Bone Graft Substitute: An Animal Experimental Study.
33481770	2	32	theme	combined	483:490	arg1	powder					496:501	combined DBM powder	483:501	combined DBM powder	483:501	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	33	from	degradation	422:432	arg1	mL					561:562	50 mg/1 mL	553:562	50 mg/1 mL	553:562	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	33	from	degradation	422:432	arg1	mL					578:579	100 mg/1 mL	569:579	100 mg/1 mL	569:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	33	from	degradation	422:432	arg1	mL					537:538	0 mg/1 mL	530:538	0 mg/1 mL	530:538	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	33	from	degradation	422:432	arg1	mL					549:550	25 mg/1 mL	541:550	25 mg/1 mL	541:550	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	33	from	degradation	422:432	arg1	amounts					519:525	amounts	519:525	amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	519:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	34	from	amounts	519:525	arg1	degradation					422:432	in vitro degradation	413:432	in vitro degradation	413:432	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	34	from	amounts	519:525	arg1	swelling					447:454	equilibrium swelling	435:454	equilibrium swelling	435:454	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	34	from	amounts	519:525	arg1	morphology					378:387	surface morphology	370:387	surface morphology	370:387	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	34	from	amounts	519:525	arg1	measurements					399:410	porosity measurements	390:410	porosity measurements	390:410	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	34	from	amounts	519:525	arg1	testing					472:478	mechanical testing	461:478	mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	461:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	3	35	theme	composites	756:765	arg1	osteoinductivity					716:731	osteoinductivity	716:731	osteoinductivity	716:731	In vitro cell culture and in vivo studies using Sprague-Dawley rats were performed to evaluate the biocompatibility and osteoinductivity of DBM-alginate (ADBM) composites.
33481770	3	35	theme	composites	756:765	arg1	biocompatibility					695:710	biocompatibility	695:710	biocompatibility	695:710	In vitro cell culture and in vivo studies using Sprague-Dawley rats were performed to evaluate the biocompatibility and osteoinductivity of DBM-alginate (ADBM) composites.
33481770	0	36	theme	Bone	87:90	arg1	Graft					92:96	a Bone Graft	85:96	a Bone Graft	85:96	Evaluation of Demineralized Bone Matrix Particles Delivered by Alginate Hydrogel for a Bone Graft Substitute: An Animal Experimental Study.
33481770	3	37	dep	biocompatibility	695:710	arg1	the					691:693	the	691:693	the	691:693	In vitro cell culture and in vivo studies using Sprague-Dawley rats were performed to evaluate the biocompatibility and osteoinductivity of DBM-alginate (ADBM) composites.
33481770	2	38	theme	alginate	507:514	arg1	degradation					422:432	in vitro degradation	413:432	in vitro degradation	413:432	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	38	theme	alginate	507:514	arg1	swelling					447:454	equilibrium swelling	435:454	equilibrium swelling	435:454	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	38	theme	alginate	507:514	arg1	morphology					378:387	surface morphology	370:387	surface morphology	370:387	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	38	theme	alginate	507:514	arg1	measurements					399:410	porosity measurements	390:410	porosity measurements	390:410	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	38	theme	alginate	507:514	arg1	testing					472:478	mechanical testing	461:478	mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	461:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	39	theme	mL	578:579	arg1	mL					561:562	50 mg/1 mL	553:562	50 mg/1 mL	553:562	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	39	theme	mL	578:579	arg1	mL					578:579	100 mg/1 mL	569:579	100 mg/1 mL	569:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	39	theme	mL	578:579	arg1	mL					537:538	0 mg/1 mL	530:538	0 mg/1 mL	530:538	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	39	theme	mL	578:579	arg1	mL					549:550	25 mg/1 mL	541:550	25 mg/1 mL	541:550	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	39	theme	mL	578:579	arg1	amounts					519:525	amounts	519:525	amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	519:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	8	40	theme	osteogenic	1293:1302	arg1	potential					1304:1312	greater osteogenic potential	1285:1312	greater osteogenic potential	1285:1312	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	2	41	theme	porosity	390:397	arg1	measurements					399:410	porosity measurements	390:410	porosity measurements	390:410	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	6	42	theme	DBM	1010:1012	arg1	particles					1014:1022	DBM particles	1010:1022	DBM particles	1010:1022	As the concentration of DBM particles in composites increased, degradation in collagenase and elastic modulus increased and the pore area and swelling ratio significantly decreased.
33481770	2	43	theme	swelling	447:454	arg1	properties					356:365	The physiochemical properties	337:365	The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	337:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	44	dep	MATERIAL	316:323	arg1	properties					356:365	The physiochemical properties	337:365	The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	337:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	45	theme	morphology	378:387	arg1	properties					356:365	The physiochemical properties	337:365	The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	337:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	0	46	theme	Demineralized	14:26	arg1	Particles					40:48	Demineralized Bone Matrix Particles	14:48	Demineralized Bone Matrix Particles Delivered by Alginate Hydrogel for a Bone Graft	14:96	Evaluation of Demineralized Bone Matrix Particles Delivered by Alginate Hydrogel for a Bone Graft Substitute: An Animal Experimental Study.
33481770	5	47	theme	low	906:908	arg1	rate					922:925	a similar low degradation rate	896:925	a similar low degradation rate	896:925	All composites showed a similar low degradation rate, with approximately 85% of weight remaining after 15 days.
33481770	2	48	theme	testing	472:478	arg1	properties					356:365	The physiochemical properties	337:365	The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	337:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	11	49	theme	promising	1847:1855	arg1	approach					1857:1864	a promising approach	1845:1864	a promising approach	1845:1864	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33481770	11	49	theme	promising	1847:1855	arg1	delivery					1768:1775	The delivery	1764:1775	The delivery of DBM particles using a synthetic alginate hydrogel carrier	1764:1836	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33481770	0	50	theme	Matrix	33:38	arg1	Particles					40:48	Demineralized Bone Matrix Particles	14:48	Demineralized Bone Matrix Particles Delivered by Alginate Hydrogel for a Bone Graft	14:96	Evaluation of Demineralized Bone Matrix Particles Delivered by Alginate Hydrogel for a Bone Graft Substitute: An Animal Experimental Study.
33481770	2	51	from	morphology	378:387	arg1	mL					561:562	50 mg/1 mL	553:562	50 mg/1 mL	553:562	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	51	from	morphology	378:387	arg1	mL					578:579	100 mg/1 mL	569:579	100 mg/1 mL	569:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	51	from	morphology	378:387	arg1	mL					537:538	0 mg/1 mL	530:538	0 mg/1 mL	530:538	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	51	from	morphology	378:387	arg1	mL					549:550	25 mg/1 mL	541:550	25 mg/1 mL	541:550	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	51	from	morphology	378:387	arg1	amounts					519:525	amounts	519:525	amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	519:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	8	52	theme	alkaline	1348:1355	arg1	phosphatase					1357:1367	alkaline phosphatase	1348:1367	alkaline phosphatase	1348:1367	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	6	53	from	degradation	1049:1059	arg1	collagenase					1064:1074	collagenase	1064:1074	collagenase	1064:1074	As the concentration of DBM particles in composites increased, degradation in collagenase and elastic modulus increased and the pore area and swelling ratio significantly decreased.
33481770	6	53	from	degradation	1049:1059	arg1	modulus					1088:1094	elastic modulus	1080:1094	elastic modulus	1080:1094	As the concentration of DBM particles in composites increased, degradation in collagenase and elastic modulus increased and the pore area and swelling ratio significantly decreased.
33481770	11	54	theme	particles	1784:1792	arg1	approach					1857:1864	a promising approach	1845:1864	a promising approach	1845:1864	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33481770	11	54	theme	particles	1784:1792	arg1	delivery					1768:1775	The delivery	1764:1775	The delivery of DBM particles using a synthetic alginate hydrogel carrier	1764:1836	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33481770	9	55	theme	ADBM	1599:1602	arg1	composites					1604:1613	the ADBM composites	1595:1613	the ADBM composites was significantly greater than that of DBM particles	1595:1666	Evaluation of ectopic bone formation revealed the osteoinductivity of the ADBM composites was significantly greater than that of DBM particles.
33481770	8	56	with	cultivation	1256:1266	arg1	ADBM					1273:1276	ADBM	1273:1276	ADBM	1273:1276	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	9	57	theme	ectopic	1539:1545	arg1	formation					1552:1560	ectopic bone formation	1539:1560	ectopic bone formation	1539:1560	Evaluation of ectopic bone formation revealed the osteoinductivity of the ADBM composites was significantly greater than that of DBM particles.
33481770	7	58	theme	stem	1219:1222	arg1	MSCs					1231:1234	MSCs	1231:1234	MSCs	1231:1234	No cytotoxicity of ADBM or alginate on mesenchymal stem cells (MSCs) was observed.
33481770	7	58	theme	stem	1219:1222	arg1	cells					1224:1228	mesenchymal stem cells	1207:1228	mesenchymal stem cells (MSCs)	1207:1235	No cytotoxicity of ADBM or alginate on mesenchymal stem cells (MSCs) was observed.
33481770	8	59	theme	red	1382:1384	arg1	staining					1386:1393	alizarin red staining	1373:1393	alizarin red staining	1373:1393	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	11	60	theme	alginate	1812:1819	arg1	carrier					1830:1836	a synthetic alginate hydrogel carrier	1800:1836	a synthetic alginate hydrogel carrier	1800:1836	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33481770	9	61	theme	formation	1552:1560	arg1	Evaluation					1525:1534	Evaluation	1525:1534	Evaluation of ectopic bone formation	1525:1560	Evaluation of ectopic bone formation revealed the osteoinductivity of the ADBM composites was significantly greater than that of DBM particles.
33481770	11	62	theme	bone	1869:1872	arg1	engineering					1881:1891	bone tissue engineering	1869:1891	bone tissue engineering for bone defects	1869:1908	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33481770	2	63	theme	physiochemical	341:354	arg1	properties					356:365	The physiochemical properties	337:365	The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	337:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	3	64	dep	In	596:597	arg1	vitro					599:603	vitro	599:603	vitro	599:603	In vitro cell culture and in vivo studies using Sprague-Dawley rats were performed to evaluate the biocompatibility and osteoinductivity of DBM-alginate (ADBM) composites.
33481770	8	65	theme	marker	1437:1442	arg1	RUNX2					1450:1454	RUNX2	1450:1454	RUNX2	1450:1454	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	8	65	theme	marker	1437:1442	arg1	OPN					1462:1464	OPN	1462:1464	OPN	1462:1464	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	8	65	theme	marker	1437:1442	arg1	genes					1444:1448	marker genes RUNX2, OCN, OPN, and collagen I	1437:1480	marker genes RUNX2, OCN, OPN, and collagen I	1437:1480	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	8	65	theme	marker	1437:1442	arg1	OCN					1457:1459	OCN	1457:1459	OCN	1457:1459	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	8	65	theme	marker	1437:1442	arg1	collagen					1471:1478	collagen I	1471:1480	collagen I	1471:1480	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	2	66	theme	mg/1	556:559	arg1	mL					561:562	50 mg/1 mL	553:562	50 mg/1 mL	553:562	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	3	67	theme	in	622:623	arg1	studies					630:636	in vivo studies	622:636	in vivo studies using Sprague-Dawley rats	622:662	In vitro cell culture and in vivo studies using Sprague-Dawley rats were performed to evaluate the biocompatibility and osteoinductivity of DBM-alginate (ADBM) composites.
33481770	6	68	from	concentration	993:1005	arg1	composites					1027:1036	composites	1027:1036	composites	1027:1036	As the concentration of DBM particles in composites increased, degradation in collagenase and elastic modulus increased and the pore area and swelling ratio significantly decreased.
33481770	10	69	theme	composites	1691:1700	arg1	Osteoinduction					1669:1682	Osteoinduction	1669:1682	Osteoinduction of the composites	1669:1700	Osteoinduction of the composites was demonstrated by a cranial defect model study.
33481770	1	70	theme	bone	260:263	arg1	particles					278:286	demineralized bone matrix (DBM) particles	246:286	demineralized bone matrix (DBM) particles	246:286	BACKGROUND Our objective was to explore a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes.
33481770	8	71	dep	genes	1444:1448	arg1	RUNX2					1450:1454	RUNX2	1450:1454	RUNX2	1450:1454	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	8	71	dep	genes	1444:1448	arg1	OPN					1462:1464	OPN	1462:1464	OPN	1462:1464	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	8	71	dep	genes	1444:1448	arg1	collagen					1471:1478	collagen I	1471:1480	collagen I	1471:1480	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	8	71	dep	genes	1444:1448	arg1	OCN					1457:1459	OCN	1457:1459	OCN	1457:1459	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	8	71	dep	genes	1444:1448	arg1	genes					1444:1448	marker genes RUNX2, OCN, OPN, and collagen I	1437:1480	marker genes RUNX2, OCN, OPN, and collagen I	1437:1480	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	2	72	theme	100	569:571	arg1	mg/1					573:576	mg/1	573:576	mg/1	573:576	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	3	73	theme	Sprague-Dawley	644:657	arg1	rats					659:662	Sprague-Dawley rats	644:662	Sprague-Dawley rats	644:662	In vitro cell culture and in vivo studies using Sprague-Dawley rats were performed to evaluate the biocompatibility and osteoinductivity of DBM-alginate (ADBM) composites.
33481770	0	74	theme	Animal	113:118	arg1	Study					133:137	An Animal Experimental Study	110:137	An Animal Experimental Study	110:137	Evaluation of Demineralized Bone Matrix Particles Delivered by Alginate Hydrogel for a Bone Graft Substitute: An Animal Experimental Study.
33481770	1	75	theme	synthetic	182:190	arg1	system					219:224	a synthetic alginate hydrogel delivery system	180:224	a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes	180:313	BACKGROUND Our objective was to explore a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes.
33481770	2	76	theme	mg/1	532:535	arg1	mL					537:538	0 mg/1 mL	530:538	0 mg/1 mL	530:538	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	6	77	theme	elastic	1080:1086	arg1	modulus					1088:1094	elastic modulus	1080:1094	elastic modulus	1080:1094	As the concentration of DBM particles in composites increased, degradation in collagenase and elastic modulus increased and the pore area and swelling ratio significantly decreased.
33481770	1	78	theme	hydrogel	201:208	arg1	system					219:224	a synthetic alginate hydrogel delivery system	180:224	a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes	180:313	BACKGROUND Our objective was to explore a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes.
33481770	2	79	from	powder	496:501	arg1	mL					561:562	50 mg/1 mL	553:562	50 mg/1 mL	553:562	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	79	from	powder	496:501	arg1	mL					578:579	100 mg/1 mL	569:579	100 mg/1 mL	569:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	79	from	powder	496:501	arg1	mL					537:538	0 mg/1 mL	530:538	0 mg/1 mL	530:538	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	79	from	powder	496:501	arg1	mL					549:550	25 mg/1 mL	541:550	25 mg/1 mL	541:550	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	79	from	powder	496:501	arg1	amounts					519:525	amounts	519:525	amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	519:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	10	80	dep	model	1739:1743	arg1	study					1745:1749	study	1745:1749	study	1745:1749	Osteoinduction of the composites was demonstrated by a cranial defect model study.
33481770	10	81	theme	defect	1732:1737	arg1	model					1739:1743	a cranial defect model	1722:1743	a cranial defect model study	1722:1749	Osteoinduction of the composites was demonstrated by a cranial defect model study.
33481770	2	82	theme	mg/1	544:547	arg1	mL					549:550	25 mg/1 mL	541:550	25 mg/1 mL	541:550	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	83	from	alginate	507:514	arg1	mL					561:562	50 mg/1 mL	553:562	50 mg/1 mL	553:562	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	83	from	alginate	507:514	arg1	mL					578:579	100 mg/1 mL	569:579	100 mg/1 mL	569:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	83	from	alginate	507:514	arg1	mL					537:538	0 mg/1 mL	530:538	0 mg/1 mL	530:538	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	83	from	alginate	507:514	arg1	mL					549:550	25 mg/1 mL	541:550	25 mg/1 mL	541:550	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	83	from	alginate	507:514	arg1	amounts					519:525	amounts	519:525	amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	519:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	7	84	from	cytotoxicity	1171:1182	arg1	MSCs					1231:1234	MSCs	1231:1234	MSCs	1231:1234	No cytotoxicity of ADBM or alginate on mesenchymal stem cells (MSCs) was observed.
33481770	7	84	from	cytotoxicity	1171:1182	arg1	cells					1224:1228	mesenchymal stem cells	1207:1228	mesenchymal stem cells (MSCs)	1207:1235	No cytotoxicity of ADBM or alginate on mesenchymal stem cells (MSCs) was observed.
33481770	2	85	theme	DBM	492:494	arg1	powder					496:501	combined DBM powder	483:501	combined DBM powder	483:501	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	8	86	theme	genes	1444:1448	arg1	level					1428:1432	the mRNA expression level	1408:1432	the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I	1408:1480	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	8	86	theme	genes	1444:1448	arg1	activity					1395:1402	activity	1395:1402	activity	1395:1402	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	6	87	theme	swelling	1128:1135	arg1	ratio					1137:1141	swelling ratio	1128:1141	swelling ratio	1128:1141	As the concentration of DBM particles in composites increased, degradation in collagenase and elastic modulus increased and the pore area and swelling ratio significantly decreased.
33481770	2	88	from	swelling	447:454	arg1	mL					561:562	50 mg/1 mL	553:562	50 mg/1 mL	553:562	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	88	from	swelling	447:454	arg1	mL					578:579	100 mg/1 mL	569:579	100 mg/1 mL	569:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	88	from	swelling	447:454	arg1	mL					537:538	0 mg/1 mL	530:538	0 mg/1 mL	530:538	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	88	from	swelling	447:454	arg1	mL					549:550	25 mg/1 mL	541:550	25 mg/1 mL	541:550	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	88	from	swelling	447:454	arg1	amounts					519:525	amounts	519:525	amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	519:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	5	89	theme	degradation	910:920	arg1	rate					922:925	a similar low degradation rate	896:925	a similar low degradation rate	896:925	All composites showed a similar low degradation rate, with approximately 85% of weight remaining after 15 days.
33481770	1	90	dep	graft	297:301	arg1	substitutes					303:313	substitutes	303:313	substitutes	303:313	BACKGROUND Our objective was to explore a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes.
33481770	11	91	dep	CONCLUSIONS	1752:1762	arg1	approach					1857:1864	a promising approach	1845:1864	a promising approach	1845:1864	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33481770	11	91	dep	CONCLUSIONS	1752:1762	arg1	delivery					1768:1775	The delivery	1764:1775	The delivery of DBM particles using a synthetic alginate hydrogel carrier	1764:1836	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33481770	6	92	theme	particles	1014:1022	arg1	concentration					993:1005	the concentration	989:1005	the concentration of DBM particles in composites	989:1036	As the concentration of DBM particles in composites increased, degradation in collagenase and elastic modulus increased and the pore area and swelling ratio significantly decreased.
33481770	2	93	from	testing	472:478	arg1	mL					561:562	50 mg/1 mL	553:562	50 mg/1 mL	553:562	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	93	from	testing	472:478	arg1	mL					578:579	100 mg/1 mL	569:579	100 mg/1 mL	569:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	93	from	testing	472:478	arg1	mL					537:538	0 mg/1 mL	530:538	0 mg/1 mL	530:538	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	93	from	testing	472:478	arg1	mL					549:550	25 mg/1 mL	541:550	25 mg/1 mL	541:550	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	93	from	testing	472:478	arg1	amounts					519:525	amounts	519:525	amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	519:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	8	94	theme	greater	1285:1291	arg1	potential					1304:1312	greater osteogenic potential	1285:1312	greater osteogenic potential	1285:1312	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	2	95	theme	equilibrium	435:445	arg1	swelling					447:454	equilibrium swelling	435:454	equilibrium swelling	435:454	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	96	theme	surface	370:376	arg1	morphology					378:387	surface morphology	370:387	surface morphology	370:387	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	0	97	theme	Bone	28:31	arg1	Particles					40:48	Demineralized Bone Matrix Particles	14:48	Demineralized Bone Matrix Particles Delivered by Alginate Hydrogel for a Bone Graft	14:96	Evaluation of Demineralized Bone Matrix Particles Delivered by Alginate Hydrogel for a Bone Graft Substitute: An Animal Experimental Study.
33481770	1	98	theme	DBM	273:275	arg1	particles					278:286	demineralized bone matrix (DBM) particles	246:286	demineralized bone matrix (DBM) particles	246:286	BACKGROUND Our objective was to explore a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes.
33481770	5	99	theme	similar	898:904	arg1	rate					922:925	a similar low degradation rate	896:925	a similar low degradation rate	896:925	All composites showed a similar low degradation rate, with approximately 85% of weight remaining after 15 days.
33481770	2	100	theme	degradation	422:432	arg1	properties					356:365	The physiochemical properties	337:365	The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	337:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	1	101	dep	BACKGROUND	140:149	arg1	was					165:167	was	165:167	was to explore a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes	165:313	BACKGROUND Our objective was to explore a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes.
33481770	2	102	theme	in	413:414	arg1	degradation					422:432	in vitro degradation	413:432	in vitro degradation	413:432	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	0	103	theme	Particles	40:48	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of Demineralized Bone Matrix Particles Delivered by Alginate Hydrogel for a Bone Graft	0:96	Evaluation of Demineralized Bone Matrix Particles Delivered by Alginate Hydrogel for a Bone Graft Substitute: An Animal Experimental Study.
33481770	1	104	theme	particles	278:286	arg1	delivery					234:241	the delivery	230:241	the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes	230:313	BACKGROUND Our objective was to explore a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes.
33481770	5	105	theme	weight	954:959	arg1	%					949:949	approximately 85%	933:949	approximately 85% of weight	933:959	All composites showed a similar low degradation rate, with approximately 85% of weight remaining after 15 days.
33481770	5	105	theme	weight	954:959	arg1	weight					954:959	weight	954:959	weight	954:959	All composites showed a similar low degradation rate, with approximately 85% of weight remaining after 15 days.
33481770	2	106	theme	mechanical	461:470	arg1	testing					472:478	mechanical testing	461:478	mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	461:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	107	theme	measurements	399:410	arg1	properties					356:365	The physiochemical properties	337:365	The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	337:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	1	108	theme	bone	292:295	arg1	graft					297:301	bone graft	292:301	bone graft substitutes	292:313	BACKGROUND Our objective was to explore a synthetic alginate hydrogel delivery system for the delivery of demineralized bone matrix (DBM) particles for bone graft substitutes.
33481770	3	109	theme	cell	605:608	arg1	culture					610:616	In vitro cell culture	596:616	In vitro cell culture	596:616	In vitro cell culture and in vivo studies using Sprague-Dawley rats were performed to evaluate the biocompatibility and osteoinductivity of DBM-alginate (ADBM) composites.
33481770	2	110	dep	in	413:414	arg1	vitro					416:420	vitro	416:420	vitro	416:420	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	7	111	theme	mesenchymal	1207:1217	arg1	MSCs					1231:1234	MSCs	1231:1234	MSCs	1231:1234	No cytotoxicity of ADBM or alginate on mesenchymal stem cells (MSCs) was observed.
33481770	7	111	theme	mesenchymal	1207:1217	arg1	cells					1224:1228	mesenchymal stem cells	1207:1228	mesenchymal stem cells (MSCs)	1207:1235	No cytotoxicity of ADBM or alginate on mesenchymal stem cells (MSCs) was observed.
33481770	3	112	theme	In	596:597	arg1	culture					610:616	In vitro cell culture	596:616	In vitro cell culture	596:616	In vitro cell culture and in vivo studies using Sprague-Dawley rats were performed to evaluate the biocompatibility and osteoinductivity of DBM-alginate (ADBM) composites.
33481770	8	113	theme	phosphatase	1357:1367	arg1	upregulation					1332:1343	the upregulation	1328:1343	the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I	1328:1480	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	11	114	theme	DBM	1780:1782	arg1	particles					1784:1792	DBM particles	1780:1792	DBM particles using a synthetic alginate hydrogel carrier	1780:1836	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33481770	9	115	theme	bone	1547:1550	arg1	formation					1552:1560	ectopic bone formation	1539:1560	ectopic bone formation	1539:1560	Evaluation of ectopic bone formation revealed the osteoinductivity of the ADBM composites was significantly greater than that of DBM particles.
33481770	2	116	from	measurements	399:410	arg1	mL					561:562	50 mg/1 mL	553:562	50 mg/1 mL	553:562	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	116	from	measurements	399:410	arg1	mL					578:579	100 mg/1 mL	569:579	100 mg/1 mL	569:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	116	from	measurements	399:410	arg1	mL					537:538	0 mg/1 mL	530:538	0 mg/1 mL	530:538	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	116	from	measurements	399:410	arg1	mL					549:550	25 mg/1 mL	541:550	25 mg/1 mL	541:550	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	2	116	from	measurements	399:410	arg1	amounts					519:525	amounts	519:525	amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL	519:579	MATERIAL AND METHODS The physiochemical properties of surface morphology, porosity measurements, in vitro degradation, equilibrium swelling, and mechanical testing of combined DBM powder and alginate in amounts of 0 mg/1 mL, 25 mg/1 mL, 50 mg/1 mL, and 100 mg/1 mL were detected.
33481770	7	117	theme	alginate	1195:1202	arg1	cytotoxicity					1171:1182	No cytotoxicity	1168:1182	No cytotoxicity of ADBM or alginate on mesenchymal stem cells (MSCs)	1168:1235	No cytotoxicity of ADBM or alginate on mesenchymal stem cells (MSCs) was observed.
33481770	8	118	theme	alizarin	1373:1380	arg1	staining					1386:1393	alizarin red staining	1373:1393	alizarin red staining	1373:1393	Cell cultivation with ADBM showed greater osteogenic potential, evidenced by the upregulation of alkaline phosphatase and alizarin red staining activity and the mRNA expression level of marker genes RUNX2, OCN, OPN, and collagen I compared with the cells grown in alginate.
33481770	11	119	theme	hydrogel	1821:1828	arg1	carrier					1830:1836	a synthetic alginate hydrogel carrier	1800:1836	a synthetic alginate hydrogel carrier	1800:1836	CONCLUSIONS The delivery of DBM particles using a synthetic alginate hydrogel carrier may be a promising approach in bone tissue engineering for bone defects.
33982127	5	0	theme	foods	771:775	arg1	intake					727:732	intake	727:732	intake of probiotics, prebiotics, fermented foods, and dietary plants	727:795	Evidence also suggests that remodeling the gut microbiota through intake of probiotics, prebiotics, fermented foods, and dietary plants, as well as by fecal microbiota transplantation, are feasible methods to remediate obesity.
33982127	4	1	theme	microbial	482:490	arg1	changes					492:498	Intestinal microbial changes	471:498	Intestinal microbial changes	471:498	Intestinal microbial changes alter the composition of bile acids and fatty acids and regulate bacterial lipopolysaccharide production, all of which influence energy metabolism and immunity.
33982127	4	2	theme	bacterial	565:573	arg1	lipopolysaccharide					575:592	bacterial lipopolysaccharide	565:592	bacterial lipopolysaccharide production	565:603	Intestinal microbial changes alter the composition of bile acids and fatty acids and regulate bacterial lipopolysaccharide production, all of which influence energy metabolism and immunity.
33982127	2	3	theme	gut	326:328	arg1	microbiota					330:339	the gut microbiota	322:339	the gut microbiota	322:339	As recent studies have revealed that the gut microbiota is closely linked to obesity, researchers have used various approaches to modulate the gut microbiota to treat the condition.
33982127	5	4	dep	remodeling	689:698	arg1	methods					859:865	feasible methods	850:865	feasible methods	850:865	Evidence also suggests that remodeling the gut microbiota through intake of probiotics, prebiotics, fermented foods, and dietary plants, as well as by fecal microbiota transplantation, are feasible methods to remediate obesity.
33982127	5	5	theme	probiotics	737:746	arg1	intake					727:732	intake	727:732	intake of probiotics, prebiotics, fermented foods, and dietary plants	727:795	Evidence also suggests that remodeling the gut microbiota through intake of probiotics, prebiotics, fermented foods, and dietary plants, as well as by fecal microbiota transplantation, are feasible methods to remediate obesity.
33982127	4	6	theme	lipopolysaccharide	575:592	arg1	production					594:603	bacterial lipopolysaccharide production	565:603	bacterial lipopolysaccharide production	565:603	Intestinal microbial changes alter the composition of bile acids and fatty acids and regulate bacterial lipopolysaccharide production, all of which influence energy metabolism and immunity.
33982127	5	7	theme	prebiotics	749:758	arg1	intake					727:732	intake	727:732	intake of probiotics, prebiotics, fermented foods, and dietary plants	727:795	Evidence also suggests that remodeling the gut microbiota through intake of probiotics, prebiotics, fermented foods, and dietary plants, as well as by fecal microbiota transplantation, are feasible methods to remediate obesity.
33982127	4	8	theme	Intestinal	471:480	arg1	changes					492:498	Intestinal microbial changes	471:498	Intestinal microbial changes	471:498	Intestinal microbial changes alter the composition of bile acids and fatty acids and regulate bacterial lipopolysaccharide production, all of which influence energy metabolism and immunity.
33982127	1	9	theme	economic	156:163	arg1	worldwide					172:180	a health and economic burden worldwide	143:180	worldwide	172:180	The rate of obesity is rapidly increasing and has become a health and economic burden worldwide.
33982127	2	10	theme	various	291:297	arg1	approaches					299:308	various approaches	291:308	various approaches	291:308	As recent studies have revealed that the gut microbiota is closely linked to obesity, researchers have used various approaches to modulate the gut microbiota to treat the condition.
33982127	1	11	theme	burden	165:170	arg1	worldwide					172:180	a health and economic burden worldwide	143:180	worldwide	172:180	The rate of obesity is rapidly increasing and has become a health and economic burden worldwide.
33982127	3	12	theme	Dietary	365:371	arg1	composition					373:383	Dietary composition	365:383	Dietary composition	365:383	Dietary composition and energy intake strongly affect the composition and function of the gut microbiota.
33982127	4	13	theme	fatty	540:544	arg1	acids					546:550	fatty acids	540:550	fatty acids	540:550	Intestinal microbial changes alter the composition of bile acids and fatty acids and regulate bacterial lipopolysaccharide production, all of which influence energy metabolism and immunity.
33982127	5	14	theme	gut	704:706	arg1	microbiota					708:717	the gut microbiota	700:717	the gut microbiota	700:717	Evidence also suggests that remodeling the gut microbiota through intake of probiotics, prebiotics, fermented foods, and dietary plants, as well as by fecal microbiota transplantation, are feasible methods to remediate obesity.
33982127	4	15	theme	energy	629:634	arg1	metabolism					636:645	energy metabolism	629:645	energy metabolism	629:645	Intestinal microbial changes alter the composition of bile acids and fatty acids and regulate bacterial lipopolysaccharide production, all of which influence energy metabolism and immunity.
33982127	0	16	theme	Gut	14:16	arg1	Microbiota					18:27	the Gut Microbiota	10:27	the Gut Microbiota	10:27	Targeting the Gut Microbiota for Remediating Obesity and Related Metabolic Disorders.
33982127	1	17	theme	obesity	98:104	arg1	rate					90:93	The rate	86:93	The rate of obesity	86:104	The rate of obesity is rapidly increasing and has become a health and economic burden worldwide.
33982127	5	18	theme	microbiota	818:827	arg1	transplantation					829:843	fecal microbiota transplantation	812:843	fecal microbiota transplantation	812:843	Evidence also suggests that remodeling the gut microbiota through intake of probiotics, prebiotics, fermented foods, and dietary plants, as well as by fecal microbiota transplantation, are feasible methods to remediate obesity.
33982127	3	19	theme	energy	389:394	arg1	intake					396:401	energy intake	389:401	energy intake	389:401	Dietary composition and energy intake strongly affect the composition and function of the gut microbiota.
33982127	4	20	theme	acids	546:550	arg1	composition					510:520	the composition	506:520	the composition of bile acids and fatty acids	506:550	Intestinal microbial changes alter the composition of bile acids and fatty acids and regulate bacterial lipopolysaccharide production, all of which influence energy metabolism and immunity.
33982127	2	21	attach	linked	250:255	arg1	obesity					260:266	obesity	260:266	obesity	260:266	As recent studies have revealed that the gut microbiota is closely linked to obesity, researchers have used various approaches to modulate the gut microbiota to treat the condition.
33982127	2	21	attach	linked	250:255	arg2	microbiota					228:237	the gut microbiota	220:237	the gut microbiota	220:237	As recent studies have revealed that the gut microbiota is closely linked to obesity, researchers have used various approaches to modulate the gut microbiota to treat the condition.
33982127	5	22	theme	dietary	782:788	arg1	plants					790:795	dietary plants	782:795	dietary plants	782:795	Evidence also suggests that remodeling the gut microbiota through intake of probiotics, prebiotics, fermented foods, and dietary plants, as well as by fecal microbiota transplantation, are feasible methods to remediate obesity.
33982127	5	23	theme	plants	790:795	arg1	intake					727:732	intake	727:732	intake of probiotics, prebiotics, fermented foods, and dietary plants	727:795	Evidence also suggests that remodeling the gut microbiota through intake of probiotics, prebiotics, fermented foods, and dietary plants, as well as by fecal microbiota transplantation, are feasible methods to remediate obesity.
33982127	5	24	theme	fermented	761:769	arg1	foods					771:775	fermented foods	761:775	fermented foods	761:775	Evidence also suggests that remodeling the gut microbiota through intake of probiotics, prebiotics, fermented foods, and dietary plants, as well as by fecal microbiota transplantation, are feasible methods to remediate obesity.
33982127	4	25	theme	acids	530:534	arg1	composition					510:520	the composition	506:520	the composition of bile acids and fatty acids	506:550	Intestinal microbial changes alter the composition of bile acids and fatty acids and regulate bacterial lipopolysaccharide production, all of which influence energy metabolism and immunity.
33982127	3	26	dep	composition	423:433	arg1	the					419:421	the	419:421	the	419:421	Dietary composition and energy intake strongly affect the composition and function of the gut microbiota.
33982127	4	27	theme	bile	525:528	arg1	acids					530:534	bile acids	525:534	bile acids	525:534	Intestinal microbial changes alter the composition of bile acids and fatty acids and regulate bacterial lipopolysaccharide production, all of which influence energy metabolism and immunity.
33982127	2	28	theme	recent	186:191	arg1	studies					193:199	recent studies	186:199	recent studies	186:199	As recent studies have revealed that the gut microbiota is closely linked to obesity, researchers have used various approaches to modulate the gut microbiota to treat the condition.
33982127	3	29	theme	gut	455:457	arg1	microbiota					459:468	the gut microbiota	451:468	the gut microbiota	451:468	Dietary composition and energy intake strongly affect the composition and function of the gut microbiota.
33982127	3	30	theme	microbiota	459:468	arg1	function					439:446	function	439:446	function	439:446	Dietary composition and energy intake strongly affect the composition and function of the gut microbiota.
33982127	3	30	theme	microbiota	459:468	arg1	composition					423:433	composition	423:433	composition	423:433	Dietary composition and energy intake strongly affect the composition and function of the gut microbiota.
33982127	2	31	used	used	286:289	arg2	researchers					269:279	researchers	269:279	researchers	269:279	As recent studies have revealed that the gut microbiota is closely linked to obesity, researchers have used various approaches to modulate the gut microbiota to treat the condition.
33982127	0	32	theme	Metabolic	65:73	arg1	Disorders					75:83	Related Metabolic Disorders	57:83	Related Metabolic Disorders	57:83	Targeting the Gut Microbiota for Remediating Obesity and Related Metabolic Disorders.
33982127	5	33	theme	fecal	812:816	arg1	transplantation					829:843	fecal microbiota transplantation	812:843	fecal microbiota transplantation	812:843	Evidence also suggests that remodeling the gut microbiota through intake of probiotics, prebiotics, fermented foods, and dietary plants, as well as by fecal microbiota transplantation, are feasible methods to remediate obesity.
33982127	5	34	theme	feasible	850:857	arg1	methods					859:865	feasible methods	850:865	feasible methods	850:865	Evidence also suggests that remodeling the gut microbiota through intake of probiotics, prebiotics, fermented foods, and dietary plants, as well as by fecal microbiota transplantation, are feasible methods to remediate obesity.
33982127	0	35	theme	Related	57:63	arg1	Disorders					75:83	Related Metabolic Disorders	57:83	Related Metabolic Disorders	57:83	Targeting the Gut Microbiota for Remediating Obesity and Related Metabolic Disorders.
33982127	2	36	theme	gut	224:226	arg1	microbiota					228:237	the gut microbiota	220:237	the gut microbiota	220:237	As recent studies have revealed that the gut microbiota is closely linked to obesity, researchers have used various approaches to modulate the gut microbiota to treat the condition.
34396936	6	0	theme	different	973:981	arg1	phases					983:988	the different phases	969:988	the different phases	969:988	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	7	1	theme	in vitro	1281:1288	arg1	behavior					1301:1308	the in vitro biological behavior	1277:1308	the in vitro biological behavior of the hybrid tubular scaffolds	1277:1340	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	8	2	theme	neural	1534:1539	arg1	precursors					1541:1550	neural precursors	1534:1550	neural precursors	1534:1550	Furthermore, the differentiation and survival of neural precursors was not compromised, despite alleged safety concerns.
34396936	6	3	theme	nanometric	1140:1149	arg1	phase					1151:1155	the nanometric phase	1136:1155	the nanometric phase	1136:1155	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	6	4	theme	electrical	1057:1066	arg1	permittivity					1068:1079	its relative electrical permittivity	1044:1079	its relative electrical permittivity	1044:1079	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	4	5	theme	conduits	730:737	arg1	shape					709:713	the shape	705:713	the shape of cylindrical conduits aimed at promoting and improving neural stem cell differentiation and regeneration in neural tracts	705:837	These nanohybrid matrices were next processed in the shape of cylindrical conduits aimed at promoting and improving neural stem cell differentiation and regeneration in neural tracts.
34396936	3	6	theme	silica	585:590	arg1	nanoparticles					592:604	mesoporous silica nanoparticles	574:604	mesoporous silica nanoparticles	574:604	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	3	6	theme	silica	585:590	arg1	nanotubes					563:571	carbon nanotubes	556:571	carbon nanotubes	556:571	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	6	7	theme	relative	1048:1055	arg1	permittivity					1068:1079	its relative electrical permittivity	1044:1079	its relative electrical permittivity	1044:1079	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	2	8	theme	mechanical	360:369	arg1	properties					371:380	mechanical properties	360:380	mechanical properties	360:380	Despite these features, the problems related to their handling and mechanical properties have not yet been solved.
34396936	2	9	theme	related	330:336	arg1	problems					321:328	the problems	317:328	the problems related to their handling and mechanical properties	317:380	Despite these features, the problems related to their handling and mechanical properties have not yet been solved.
34396936	6	10	from	potential	1221:1229	arg1	approaches					1255:1264	combined therapeutic approaches	1234:1264	combined therapeutic approaches	1234:1264	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	4	11	theme	neural	772:777	arg1	differentiation					789:803	neural stem cell differentiation	772:803	neural stem cell differentiation	772:803	These nanohybrid matrices were next processed in the shape of cylindrical conduits aimed at promoting and improving neural stem cell differentiation and regeneration in neural tracts.
34396936	5	12	theme	nerve	901:905	arg1	regeneration					907:918	peripheral nerve regeneration	890:918	peripheral nerve regeneration	890:918	These constructs could be of use specifically for peripheral nerve regeneration.
34396936	3	13	theme	materials	508:516	arg1	development					482:492	the development	478:492	the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix	478:653	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	7	14	theme	pure	1463:1466	arg1	gels					1479:1482	pure hyaluronan gels	1463:1482	pure hyaluronan gels	1463:1482	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	7	15	theme	Schwann	1391:1397	arg1	cells					1399:1403	Schwann cells	1391:1403	Schwann cells	1391:1403	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	4	16	from	regeneration	809:820	arg1	tracts					832:837	neural tracts	825:837	neural tracts	825:837	These nanohybrid matrices were next processed in the shape of cylindrical conduits aimed at promoting and improving neural stem cell differentiation and regeneration in neural tracts.
34396936	3	17	theme	mesoporous	574:583	arg1	nanoparticles					592:604	mesoporous silica nanoparticles	574:604	mesoporous silica nanoparticles	574:604	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	3	17	theme	mesoporous	574:583	arg1	nanotubes					563:571	carbon nanotubes	556:571	carbon nanotubes	556:571	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	7	18	theme	cells	1399:1403	arg1	adhesion					1366:1373	an improved early cell adhesion and survival	1343:1386	adhesion	1366:1373	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	7	18	theme	cells	1399:1403	arg1	survival					1379:1386	an improved early cell adhesion and survival	1343:1386	survival	1379:1386	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	8	19	theme	alleged	1581:1587	arg1	safety					1589:1594	alleged safety concerns	1581:1603	alleged safety concerns	1581:1603	Furthermore, the differentiation and survival of neural precursors was not compromised, despite alleged safety concerns.
34396936	7	20	theme	biological	1290:1299	arg1	behavior					1301:1308	the in vitro biological behavior	1277:1308	the in vitro biological behavior of the hybrid tubular scaffolds	1277:1340	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	1	21	theme	Hyaluronan-based	96:111	arg1	hydrogels					113:121	Hyaluronan-based hydrogels	96:121	Hyaluronan-based hydrogels	96:121	Hyaluronan-based hydrogels are among the most promising neural tissue engineering materials because of their biocompatibility and the immunomodulation capabilities of their degradation byproducts.
34396936	4	22	theme	cylindrical	718:728	arg1	conduits					730:737	cylindrical conduits	718:737	cylindrical conduits aimed at promoting and improving neural stem cell differentiation and regeneration in neural tracts	718:837	These nanohybrid matrices were next processed in the shape of cylindrical conduits aimed at promoting and improving neural stem cell differentiation and regeneration in neural tracts.
34396936	4	23	from	differentiation	789:803	arg1	tracts					832:837	neural tracts	825:837	neural tracts	825:837	These nanohybrid matrices were next processed in the shape of cylindrical conduits aimed at promoting and improving neural stem cell differentiation and regeneration in neural tracts.
34396936	4	24	theme	cell	784:787	arg1	differentiation					789:803	neural stem cell differentiation	772:803	neural stem cell differentiation	772:803	These nanohybrid matrices were next processed in the shape of cylindrical conduits aimed at promoting and improving neural stem cell differentiation and regeneration in neural tracts.
34396936	4	25	theme	neural	825:830	arg1	tracts					832:837	neural tracts	825:837	neural tracts	825:837	These nanohybrid matrices were next processed in the shape of cylindrical conduits aimed at promoting and improving neural stem cell differentiation and regeneration in neural tracts.
34396936	3	26	theme	nanohybrid	497:506	arg1	materials					508:516	nanohybrid materials	497:516	nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix	497:653	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	3	27	theme	present	415:421	arg1	work					423:426	the present work	411:426	the present work	411:426	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	6	28	theme	gel	1032:1034	arg1	features					1016:1023	physico-chemical features	999:1023	physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus	999:1113	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	6	28	theme	gel	1032:1034	arg1	permittivity					1068:1079	its relative electrical permittivity	1044:1079	its relative electrical permittivity	1044:1079	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	6	28	theme	gel	1032:1034	arg1	intake					1088:1093	water intake	1082:1093	water intake	1082:1093	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	6	28	theme	gel	1032:1034	arg1	modulus					1107:1113	elastic modulus	1099:1113	elastic modulus	1099:1113	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	6	29	theme	study	936:940	arg1	Results					921:927	Results	921:927	Results of the study	921:940	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	1	30	theme	immunomodulation	230:245	arg1	capabilities					247:258	the immunomodulation capabilities	226:258	the immunomodulation capabilities of their degradation byproducts	226:290	Hyaluronan-based hydrogels are among the most promising neural tissue engineering materials because of their biocompatibility and the immunomodulation capabilities of their degradation byproducts.
34396936	3	31	dep	phases	548:553	arg1	nanoparticles					592:604	mesoporous silica nanoparticles	574:604	mesoporous silica nanoparticles	574:604	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	3	31	dep	phases	548:553	arg1	nanotubes					563:571	carbon nanotubes	556:571	carbon nanotubes	556:571	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	7	32	theme	hybrid	1317:1322	arg1	scaffolds					1332:1340	the hybrid tubular scaffolds	1313:1340	the hybrid tubular scaffolds	1313:1340	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	3	33	theme	hyaluronan	637:646	arg1	matrix					648:653	a crosslinked hyaluronan matrix	623:653	a crosslinked hyaluronan matrix	623:653	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	3	34	from	matrix	648:653	arg1	embedded					611:618	embedded	611:618	embedded	611:618	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	7	35	theme	early	1355:1359	arg1	adhesion					1366:1373	an improved early cell adhesion and survival	1343:1386	adhesion	1366:1373	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	3	36	link	crosslinked	625:635	arg1	matrix					648:653	a crosslinked hyaluronan matrix	623:653	a crosslinked hyaluronan matrix	623:653	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	0	37	theme	hyaluronan	30:39	arg1	evaluation					16:25	evaluation	16:25	evaluation	16:25	Development and evaluation of hyaluronan nanocomposite conduits for neural tissue regeneration.
34396936	0	37	theme	hyaluronan	30:39	arg1	Development					0:10	Development	0:10	Development	0:10	Development and evaluation of hyaluronan nanocomposite conduits for neural tissue regeneration.
34396936	6	38	theme	water	1082:1086	arg1	intake					1088:1093	water intake	1082:1093	water intake	1082:1093	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	6	39	theme	elastic	1099:1105	arg1	modulus					1107:1113	elastic modulus	1099:1113	elastic modulus	1099:1113	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	8	40	theme	precursors	1541:1550	arg1	survival					1522:1529	survival	1522:1529	survival	1522:1529	Furthermore, the differentiation and survival of neural precursors was not compromised, despite alleged safety concerns.
34396936	8	40	theme	precursors	1541:1550	arg1	differentiation					1502:1516	differentiation	1502:1516	differentiation	1502:1516	Furthermore, the differentiation and survival of neural precursors was not compromised, despite alleged safety concerns.
34396936	3	41	theme	different	527:535	arg1	phases					548:553	different nanometric phases	527:553	different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles)	527:605	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	6	42	theme	physico-chemical	999:1014	arg1	features					1016:1023	physico-chemical features	999:1023	physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus	999:1113	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	6	42	theme	physico-chemical	999:1014	arg1	permittivity					1068:1079	its relative electrical permittivity	1044:1079	its relative electrical permittivity	1044:1079	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	6	42	theme	physico-chemical	999:1014	arg1	intake					1088:1093	water intake	1082:1093	water intake	1082:1093	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	6	42	theme	physico-chemical	999:1014	arg1	modulus					1107:1113	elastic modulus	1099:1113	elastic modulus	1099:1113	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	7	43	theme	scaffolds	1332:1340	arg1	behavior					1301:1308	the in vitro biological behavior	1277:1308	the in vitro biological behavior of the hybrid tubular scaffolds	1277:1340	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	3	44	theme	crosslinked	625:635	arg1	matrix					648:653	a crosslinked hyaluronan matrix	623:653	a crosslinked hyaluronan matrix	623:653	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	7	45	from	adhesion	1366:1373	arg1	lumen					1414:1418	their lumen	1408:1418	their lumen	1408:1418	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	3	46	theme	nanometric	537:546	arg1	phases					548:553	different nanometric phases	527:553	different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles)	527:605	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	7	47	theme	tubular	1324:1330	arg1	scaffolds					1332:1340	the hybrid tubular scaffolds	1313:1340	the hybrid tubular scaffolds	1313:1340	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	1	48	theme	tissue	159:164	arg1	materials					178:186	the most promising neural tissue engineering materials	133:186	the most promising neural tissue engineering materials	133:186	Hyaluronan-based hydrogels are among the most promising neural tissue engineering materials because of their biocompatibility and the immunomodulation capabilities of their degradation byproducts.
34396936	3	49	from	materials	508:516	arg1	embedded					611:618	embedded	611:618	embedded	611:618	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	1	50	theme	promising	142:150	arg1	materials					178:186	the most promising neural tissue engineering materials	133:186	the most promising neural tissue engineering materials	133:186	Hyaluronan-based hydrogels are among the most promising neural tissue engineering materials because of their biocompatibility and the immunomodulation capabilities of their degradation byproducts.
34396936	8	51	dep	safety	1589:1594	arg1	concerns					1596:1603	concerns	1596:1603	concerns	1596:1603	Furthermore, the differentiation and survival of neural precursors was not compromised, despite alleged safety concerns.
34396936	7	52	theme	hyaluronan	1468:1477	arg1	gels					1479:1482	pure hyaluronan gels	1463:1482	pure hyaluronan gels	1463:1482	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	7	53	theme	improved	1346:1353	arg1	adhesion					1366:1373	an improved early cell adhesion and survival	1343:1386	adhesion	1366:1373	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	4	54	theme	stem	779:782	arg1	differentiation					789:803	neural stem cell differentiation	772:803	neural stem cell differentiation	772:803	These nanohybrid matrices were next processed in the shape of cylindrical conduits aimed at promoting and improving neural stem cell differentiation and regeneration in neural tracts.
34396936	7	55	from	survival	1379:1386	arg1	lumen					1414:1418	their lumen	1408:1418	their lumen	1408:1418	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	1	56	theme	neural	152:157	arg1	materials					178:186	the most promising neural tissue engineering materials	133:186	the most promising neural tissue engineering materials	133:186	Hyaluronan-based hydrogels are among the most promising neural tissue engineering materials because of their biocompatibility and the immunomodulation capabilities of their degradation byproducts.
34396936	3	57	from	embedded	611:618	arg1	matrix					648:653	a crosslinked hyaluronan matrix	623:653	a crosslinked hyaluronan matrix	623:653	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	3	57	from	embedded	611:618	arg1	materials					508:516	nanohybrid materials	497:516	nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix	497:653	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	1	58	theme	degradation	269:279	arg1	byproducts					281:290	their degradation byproducts	263:290	their degradation byproducts	263:290	Hyaluronan-based hydrogels are among the most promising neural tissue engineering materials because of their biocompatibility and the immunomodulation capabilities of their degradation byproducts.
34396936	0	59	theme	tissue	75:80	arg1	regeneration					82:93	neural tissue regeneration	68:93	neural tissue regeneration	68:93	Development and evaluation of hyaluronan nanocomposite conduits for neural tissue regeneration.
34396936	7	60	theme	cell	1361:1364	arg1	adhesion					1366:1373	an improved early cell adhesion and survival	1343:1386	adhesion	1366:1373	Regarding the in vitro biological behavior of the hybrid tubular scaffolds, an improved early cell adhesion and survival of Schwann cells in their lumen was found, as compared to conduits made of pure hyaluronan gels.
34396936	5	61	theme	peripheral	890:899	arg1	regeneration					907:918	peripheral nerve regeneration	890:918	peripheral nerve regeneration	890:918	These constructs could be of use specifically for peripheral nerve regeneration.
34396936	3	62	theme	carbon	556:561	arg1	nanoparticles					592:604	mesoporous silica nanoparticles	574:604	mesoporous silica nanoparticles	574:604	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	3	62	theme	carbon	556:561	arg1	nanotubes					563:571	carbon nanotubes	556:571	carbon nanotubes	556:571	In the present work it is proposed to address these drawbacks through the development of nanohybrid materials in which different nanometric phases (carbon nanotubes, mesoporous silica nanoparticles) are embedded in a crosslinked hyaluronan matrix.
34396936	1	63	theme	byproducts	281:290	arg1	biocompatibility					205:220	their biocompatibility	199:220	their biocompatibility	199:220	Hyaluronan-based hydrogels are among the most promising neural tissue engineering materials because of their biocompatibility and the immunomodulation capabilities of their degradation byproducts.
34396936	1	63	theme	byproducts	281:290	arg1	capabilities					247:258	the immunomodulation capabilities	226:258	the immunomodulation capabilities of their degradation byproducts	226:290	Hyaluronan-based hydrogels are among the most promising neural tissue engineering materials because of their biocompatibility and the immunomodulation capabilities of their degradation byproducts.
34396936	0	64	theme	neural	68:73	arg1	regeneration					82:93	neural tissue regeneration	68:93	neural tissue regeneration	68:93	Development and evaluation of hyaluronan nanocomposite conduits for neural tissue regeneration.
34396936	6	65	theme	phases	983:988	arg1	inclusion					956:964	the inclusion	952:964	the inclusion of the different phases	952:988	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	6	66	theme	therapeutic	1243:1253	arg1	approaches					1255:1264	combined therapeutic approaches	1234:1264	combined therapeutic approaches	1234:1264	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	6	67	theme	combined	1234:1241	arg1	approaches					1255:1264	combined therapeutic approaches	1234:1264	combined therapeutic approaches	1234:1264	Results of the study show that the inclusion of the different phases improved physico-chemical features of the gel such as its relative electrical permittivity, water intake and elastic modulus, giving hints on how the nanometric phase interacts with hyaluronan in the composite as well as for their potential in combined therapeutic approaches.
34396936	1	68	theme	engineering	166:176	arg1	materials					178:186	the most promising neural tissue engineering materials	133:186	the most promising neural tissue engineering materials	133:186	Hyaluronan-based hydrogels are among the most promising neural tissue engineering materials because of their biocompatibility and the immunomodulation capabilities of their degradation byproducts.
34396936	4	69	theme	nanohybrid	662:671	arg1	matrices					673:680	These nanohybrid matrices	656:680	These nanohybrid matrices	656:680	These nanohybrid matrices were next processed in the shape of cylindrical conduits aimed at promoting and improving neural stem cell differentiation and regeneration in neural tracts.
32791281	0	0	theme	unique	94:99	arg1	morphology					119:128	unique beads-on-a-string morphology	94:128	unique beads-on-a-string morphology	94:128	High mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	5	1	theme	gelatin	844:850	arg1	chains					867:872	gelatin macromolecular chains	844:872	gelatin macromolecular chains	844:872	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
32791281	5	2	theme	Schiff-base	725:735	arg1	reaction					737:744	the Schiff-base reaction	721:744	the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains	721:872	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
32791281	1	3	theme	composite	183:191	arg1	hydrogels					193:201	high mechanical strength gelatin composite hydrogels	150:201	high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology	150:278	This work prepared high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	10	4	theme	composite	1349:1357	arg1	hydrogels					1359:1367	The composite hydrogels	1345:1367	The composite hydrogels	1345:1367	The composite hydrogels could maintain their shape well in buffer solution.
32791281	5	5	theme	macromolecular	852:865	arg1	chains					867:872	gelatin macromolecular chains	844:872	gelatin macromolecular chains	844:872	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
32791281	11	6	theme	present	1425:1431	arg1	work					1433:1436	The present work	1421:1436	The present work	1421:1436	The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	2	7	theme	intensive	408:416	arg1	sonication					418:427	intensive sonication	408:427	intensive sonication	408:427	In detail, cellulose nanofibrils (H-Cel) with unique beads-on-a-string morphology were obtained by acid hydrolysis followed by intensive sonication.
32791281	11	8	theme	surface	1569:1575	arg1	nanofibrils					1596:1606	surface modified cellulose nanofibrils	1569:1606	surface modified cellulose nanofibrils with unique beads-on-a-string morphology	1569:1647	The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	6	9	theme	reinforcing	998:1008	arg1	agent					1010:1014	the reinforcing agent	994:1014	the reinforcing agent	994:1014	Since the cellulose nanofibrils were covalently bonded to gelatin, the stress could be efficiently transferred between the reinforcing agent and matrix, resulting in a composite hydrogel with drastically increased mechanical strength.
32791281	5	10	theme	network	679:685	arg1	structure					687:695	a giant network structure	671:695	a giant network structure	671:695	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
32791281	2	11	theme	beads-on-a-string	334:350	arg1	morphology					352:361	unique beads-on-a-string morphology	327:361	unique beads-on-a-string morphology	327:361	In detail, cellulose nanofibrils (H-Cel) with unique beads-on-a-string morphology were obtained by acid hydrolysis followed by intensive sonication.
32791281	6	12	theme	mechanical	1089:1098	arg1	strength					1100:1107	drastically increased mechanical strength	1067:1107	drastically increased mechanical strength	1067:1107	Since the cellulose nanofibrils were covalently bonded to gelatin, the stress could be efficiently transferred between the reinforcing agent and matrix, resulting in a composite hydrogel with drastically increased mechanical strength.
32791281	0	13	theme	beads-on-a-string	101:117	arg1	morphology					119:128	unique beads-on-a-string morphology	94:128	unique beads-on-a-string morphology	94:128	High mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	6	14	theme	increased	1079:1087	arg1	strength					1100:1107	drastically increased mechanical strength	1067:1107	drastically increased mechanical strength	1067:1107	Since the cellulose nanofibrils were covalently bonded to gelatin, the stress could be efficiently transferred between the reinforcing agent and matrix, resulting in a composite hydrogel with drastically increased mechanical strength.
32791281	0	15	with	nanofibrils	77:87	arg1	morphology					119:128	unique beads-on-a-string morphology	94:128	unique beads-on-a-string morphology	94:128	High mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	2	16	theme	unique	327:332	arg1	morphology					352:361	unique beads-on-a-string morphology	327:361	unique beads-on-a-string morphology	327:361	In detail, cellulose nanofibrils (H-Cel) with unique beads-on-a-string morphology were obtained by acid hydrolysis followed by intensive sonication.
32791281	11	17	theme	high	1506:1509	arg1	strength					1522:1529	extremely high mechanical strength	1496:1529	extremely high mechanical strength	1496:1529	The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	2	18	theme	acid	380:383	arg1	hydrolysis					385:394	acid hydrolysis	380:394	acid hydrolysis followed by intensive sonication	380:427	In detail, cellulose nanofibrils (H-Cel) with unique beads-on-a-string morphology were obtained by acid hydrolysis followed by intensive sonication.
32791281	5	19	theme	primary	820:826	arg1	groups					834:839	the primary amino groups	816:839	the primary amino groups on gelatin macromolecular chains	816:872	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
32791281	8	20	theme	SEM	1180:1182	arg1	images					1184:1189	SEM images	1180:1189	SEM images	1180:1189	SEM images showed a highly porous three-dimensional structure in the hydrogel with regulated pore size.
32791281	6	21	theme	cellulose	885:893	arg1	nanofibrils					895:905	the cellulose nanofibrils	881:905	the cellulose nanofibrils	881:905	Since the cellulose nanofibrils were covalently bonded to gelatin, the stress could be efficiently transferred between the reinforcing agent and matrix, resulting in a composite hydrogel with drastically increased mechanical strength.
32791281	11	22	theme	unique	1613:1618	arg1	morphology					1638:1647	unique beads-on-a-string morphology	1613:1647	unique beads-on-a-string morphology	1613:1647	The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	3	23	theme	hydroxyl	513:520	arg1	groups					522:527	the non-esterified hydroxyl groups	494:527	the non-esterified hydroxyl groups	494:527	The D-H-Cel nanofibrils were prepared through oxidizing part of the non-esterified hydroxyl groups on the H-Cel into aldehyde groups.
32791281	5	24	theme	amino	828:832	arg1	groups					834:839	the primary amino groups	816:839	the primary amino groups on gelatin macromolecular chains	816:872	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
32791281	11	25	theme	natural	1449:1455	arg1	hydrogels					1481:1489	natural polymer-based composite hydrogels	1449:1489	natural polymer-based composite hydrogels with extremely high mechanical strength	1449:1529	The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	8	26	theme	three-dimensional	1214:1230	arg1	structure					1232:1240	a highly porous three-dimensional structure	1198:1240	a highly porous three-dimensional structure	1198:1240	SEM images showed a highly porous three-dimensional structure in the hydrogel with regulated pore size.
32791281	3	27	theme	groups	522:527	arg1	part					486:489	part	486:489	part of the non-esterified hydroxyl groups	486:527	The D-H-Cel nanofibrils were prepared through oxidizing part of the non-esterified hydroxyl groups on the H-Cel into aldehyde groups.
32791281	0	28	theme	mechanical	5:14	arg1	composite					33:41	High mechanical strength gelatin composite	0:41	High mechanical strength gelatin composite	0:41	High mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	8	29	theme	pore	1273:1276	arg1	size					1278:1281	regulated pore size	1263:1281	regulated pore size	1263:1281	SEM images showed a highly porous three-dimensional structure in the hydrogel with regulated pore size.
32791281	11	30	theme	beads-on-a-string	1620:1636	arg1	morphology					1638:1647	unique beads-on-a-string morphology	1613:1647	unique beads-on-a-string morphology	1613:1647	The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	1	31	theme	cellulose	217:225	arg1	nanofibrils					227:237	cellulose nanofibrils	217:237	cellulose nanofibrils with unique beads-on-a-string morphology	217:278	This work prepared high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	0	32	theme	High	0:3	arg1	composite					33:41	High mechanical strength gelatin composite	0:41	High mechanical strength gelatin composite	0:41	High mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	8	33	dep	size	1278:1281	arg1	the					1245:1247	the	1245:1247	the	1245:1247	SEM images showed a highly porous three-dimensional structure in the hydrogel with regulated pore size.
32791281	8	33	dep	size	1278:1281	arg1	hydrogel					1249:1256	hydrogel	1249:1256	hydrogel	1249:1256	SEM images showed a highly porous three-dimensional structure in the hydrogel with regulated pore size.
32791281	3	34	theme	non-esterified	498:511	arg1	groups					522:527	the non-esterified hydroxyl groups	494:527	the non-esterified hydroxyl groups	494:527	The D-H-Cel nanofibrils were prepared through oxidizing part of the non-esterified hydroxyl groups on the H-Cel into aldehyde groups.
32791281	0	35	theme	gelatin	25:31	arg1	composite					33:41	High mechanical strength gelatin composite	0:41	High mechanical strength gelatin composite	0:41	High mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	11	36	theme	composite	1471:1479	arg1	hydrogels					1481:1489	natural polymer-based composite hydrogels	1449:1489	natural polymer-based composite hydrogels with extremely high mechanical strength	1449:1529	The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	9	37	theme	ninhydrin	1328:1336	arg1	assay					1338:1342	ninhydrin assay	1328:1342	ninhydrin assay	1328:1342	The crosslinking indices were measured with ninhydrin assay.
32791281	11	38	with	hydrogels	1481:1489	arg1	strength					1522:1529	extremely high mechanical strength	1496:1529	extremely high mechanical strength	1496:1529	The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	0	39	theme	strength	16:23	arg1	composite					33:41	High mechanical strength gelatin composite	0:41	High mechanical strength gelatin composite	0:41	High mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	11	40	theme	cellulose	1586:1594	arg1	nanofibrils					1596:1606	surface modified cellulose nanofibrils	1569:1606	surface modified cellulose nanofibrils with unique beads-on-a-string morphology	1569:1647	The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	11	41	theme	polymer-based	1457:1469	arg1	hydrogels					1481:1489	natural polymer-based composite hydrogels	1449:1489	natural polymer-based composite hydrogels with extremely high mechanical strength	1449:1529	The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	1	42	theme	unique	244:249	arg1	morphology					269:278	unique beads-on-a-string morphology	244:278	unique beads-on-a-string morphology	244:278	This work prepared high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	11	43	theme	mechanical	1511:1520	arg1	strength					1522:1529	extremely high mechanical strength	1496:1529	extremely high mechanical strength	1496:1529	The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	6	44	theme	composite	1043:1051	arg1	hydrogel					1053:1060	a composite hydrogel	1041:1060	a composite hydrogel with drastically increased mechanical strength	1041:1107	Since the cellulose nanofibrils were covalently bonded to gelatin, the stress could be efficiently transferred between the reinforcing agent and matrix, resulting in a composite hydrogel with drastically increased mechanical strength.
32791281	5	45	theme	D-H-Cel	792:798	arg1	nanofibrils					800:810	D-H-Cel nanofibrils	792:810	D-H-Cel nanofibrils	792:810	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
32791281	1	46	theme	beads-on-a-string	251:267	arg1	morphology					269:278	unique beads-on-a-string morphology	244:278	unique beads-on-a-string morphology	244:278	This work prepared high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	2	47	with	nanofibrils	302:312	arg1	morphology					352:361	unique beads-on-a-string morphology	327:361	unique beads-on-a-string morphology	327:361	In detail, cellulose nanofibrils (H-Cel) with unique beads-on-a-string morphology were obtained by acid hydrolysis followed by intensive sonication.
32791281	5	48	theme	nanofibrils	800:810	arg1	surface					781:787	the surface	777:787	the surface of D-H-Cel nanofibrils	777:810	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
32791281	3	49	theme	D-H-Cel	434:440	arg1	nanofibrils					442:452	The D-H-Cel nanofibrils	430:452	The D-H-Cel nanofibrils	430:452	The D-H-Cel nanofibrils were prepared through oxidizing part of the non-esterified hydroxyl groups on the H-Cel into aldehyde groups.
32791281	5	50	theme	aldehyde	758:765	arg1	groups					767:772	the aldehyde groups	754:772	the aldehyde groups on the surface of D-H-Cel nanofibrils	754:810	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
32791281	0	51	dep	hydrogels	43:51	arg1	reinforced					53:62	reinforced	53:62	hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology	43:128	High mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	8	52	theme	porous	1207:1212	arg1	structure					1232:1240	a highly porous three-dimensional structure	1198:1240	a highly porous three-dimensional structure	1198:1240	SEM images showed a highly porous three-dimensional structure in the hydrogel with regulated pore size.
32791281	4	53	theme	composite	617:625	arg1	hydrogels					627:635	D-H-Cel/Gel composite hydrogels	605:635	D-H-Cel/Gel composite hydrogels	605:635	D-H-Cel were then mixed with gelatin and D-H-Cel/Gel composite hydrogels were produced.
32791281	1	54	with	nanofibrils	227:237	arg1	morphology					269:278	unique beads-on-a-string morphology	244:278	unique beads-on-a-string morphology	244:278	This work prepared high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	4	55	theme	D-H-Cel/Gel	605:615	arg1	hydrogels					627:635	D-H-Cel/Gel composite hydrogels	605:635	D-H-Cel/Gel composite hydrogels	605:635	D-H-Cel were then mixed with gelatin and D-H-Cel/Gel composite hydrogels were produced.
32791281	7	56	theme	D-40H-Cel/Gel	1138:1150	arg1	hydrogel					1152:1159	D-40H-Cel/Gel hydrogel	1138:1159	D-40H-Cel/Gel hydrogel	1138:1159	The compressive strength of D-40H-Cel/Gel hydrogel reached 3.398 MPa.
32791281	11	57	with	nanofibrils	1596:1606	arg1	morphology					1638:1647	unique beads-on-a-string morphology	1613:1647	unique beads-on-a-string morphology	1613:1647	The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	5	58	theme	giant	673:677	arg1	structure					687:695	a giant network structure	671:695	a giant network structure	671:695	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
32791281	1	59	theme	high	150:153	arg1	hydrogels					193:201	high mechanical strength gelatin composite hydrogels	150:201	high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology	150:278	This work prepared high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	7	60	theme	hydrogel	1152:1159	arg1	strength					1126:1133	The compressive strength	1110:1133	The compressive strength of D-40H-Cel/Gel hydrogel	1110:1159	The compressive strength of D-40H-Cel/Gel hydrogel reached 3.398 MPa.
32791281	5	61	from	groups	834:839	arg1	chains					867:872	gelatin macromolecular chains	844:872	gelatin macromolecular chains	844:872	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
32791281	5	61	from	groups	834:839	arg1	surface					781:787	the surface	777:787	the surface of D-H-Cel nanofibrils	777:810	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
32791281	6	62	with	hydrogel	1053:1060	arg1	strength					1100:1107	drastically increased mechanical strength	1067:1107	drastically increased mechanical strength	1067:1107	Since the cellulose nanofibrils were covalently bonded to gelatin, the stress could be efficiently transferred between the reinforcing agent and matrix, resulting in a composite hydrogel with drastically increased mechanical strength.
32791281	11	63	theme	modified	1577:1584	arg1	nanofibrils					1596:1606	surface modified cellulose nanofibrils	1569:1606	surface modified cellulose nanofibrils with unique beads-on-a-string morphology	1569:1647	The present work shows that natural polymer-based composite hydrogels with extremely high mechanical strength could be obtained by reinforcing with surface modified cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	1	64	theme	mechanical	155:164	arg1	hydrogels					193:201	high mechanical strength gelatin composite hydrogels	150:201	high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology	150:278	This work prepared high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	3	65	theme	aldehyde	547:554	arg1	groups					556:561	aldehyde groups	547:561	aldehyde groups	547:561	The D-H-Cel nanofibrils were prepared through oxidizing part of the non-esterified hydroxyl groups on the H-Cel into aldehyde groups.
32791281	8	66	theme	regulated	1263:1271	arg1	size					1278:1281	regulated pore size	1263:1281	regulated pore size	1263:1281	SEM images showed a highly porous three-dimensional structure in the hydrogel with regulated pore size.
32791281	7	67	theme	compressive	1114:1124	arg1	strength					1126:1133	The compressive strength	1110:1133	The compressive strength of D-40H-Cel/Gel hydrogel	1110:1159	The compressive strength of D-40H-Cel/Gel hydrogel reached 3.398 MPa.
32791281	1	68	theme	strength	166:173	arg1	hydrogels					193:201	high mechanical strength gelatin composite hydrogels	150:201	high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology	150:278	This work prepared high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	0	69	theme	cellulose	67:75	arg1	nanofibrils					77:87	cellulose nanofibrils	67:87	cellulose nanofibrils with unique beads-on-a-string morphology	67:128	High mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	2	70	theme	cellulose	292:300	arg1	nanofibrils					302:312	cellulose nanofibrils	292:312	cellulose nanofibrils (H-Cel) with unique beads-on-a-string morphology	292:361	In detail, cellulose nanofibrils (H-Cel) with unique beads-on-a-string morphology were obtained by acid hydrolysis followed by intensive sonication.
32791281	2	70	theme	cellulose	292:300	arg1	H-Cel					315:319	H-Cel	315:319	H-Cel	315:319	In detail, cellulose nanofibrils (H-Cel) with unique beads-on-a-string morphology were obtained by acid hydrolysis followed by intensive sonication.
32791281	9	71	theme	crosslinking	1288:1299	arg1	indices					1301:1307	The crosslinking indices	1284:1307	The crosslinking indices	1284:1307	The crosslinking indices were measured with ninhydrin assay.
32791281	1	72	theme	gelatin	175:181	arg1	hydrogels					193:201	high mechanical strength gelatin composite hydrogels	150:201	high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology	150:278	This work prepared high mechanical strength gelatin composite hydrogels reinforced by cellulose nanofibrils with unique beads-on-a-string morphology.
32791281	10	73	theme	buffer	1404:1409	arg1	solution					1411:1418	buffer solution	1404:1418	buffer solution	1404:1418	The composite hydrogels could maintain their shape well in buffer solution.
32791281	5	74	from	groups	767:772	arg1	chains					867:872	gelatin macromolecular chains	844:872	gelatin macromolecular chains	844:872	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
32791281	5	74	from	groups	767:772	arg1	surface					781:787	the surface	777:787	the surface of D-H-Cel nanofibrils	777:810	During the mixing, a giant network structure was constructed through the Schiff-base reaction between the aldehyde groups on the surface of D-H-Cel nanofibrils and the primary amino groups on gelatin macromolecular chains.
33691185	4	0	from	time	577:580	arg1	tissue					596:601	the rectal tissue	585:601	the rectal tissue	585:601	However, low residence time in the rectal tissue limits their utility.
33691185	6	1	dep	-co-	992:995	arg1	acid					987:990	lactic acid	980:990	lactic acid	980:990	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	12	2	theme	GM-0111	2096:2102	arg1	delivery					2084:2091	rectal delivery	2077:2091	rectal delivery of GM-0111 to mice and radioprotection	2077:2130	The enhanced bioaccumulation provided by thermoresponsive SELPs via a liquid to semisolid transition improved rectal delivery of GM-0111 to mice and radioprotection in a RIP model.
33691185	2	3	theme	patient	331:337	arg1	quality					339:345	diminished patient quality	320:345	diminished patient quality of life	320:353	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	6	4	theme	ethylene	952:959	arg1	glycol					961:966	ethylene glycol	952:966	ethylene glycol	952:966	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	6	4	theme	ethylene	952:959	arg1	Poly					904:907	Poly	904:907	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers	904:1021	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	8	5	from	residues	1432:1439	arg1	repeats					1456:1462	the monomer repeats	1444:1462	the monomer repeats	1444:1462	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	11	6	theme	Histological	1855:1866	arg1	scoring					1868:1874	Histological scoring	1855:1874	Histological scoring	1855:1874	Histological scoring showed RIP injury was ameliorated for animals treated with GM-0111 delivered by SELP-415K.
33691185	10	7	theme	traditional	1822:1832	arg1	approaches					1843:1852	traditional delivery approaches	1822:1852	traditional delivery approaches	1822:1852	Rectal delivery of SAGE using SELP-415K significantly reduced behavioral pain responses, and reduced animal mass loss compared to irradiated controls or treatment with traditional delivery approaches.
33691185	1	8	theme	lower	235:239	arg1	radiotherapy					251:262	lower abdominal radiotherapy	235:262	lower abdominal radiotherapy	235:262	Radiation-induced proctitis (RIP) is a debilitating adverse event that occurs commonly during lower abdominal radiotherapy.
33691185	12	9	theme	liquid	2037:2042	arg1	transition					2057:2066	a liquid to semisolid transition	2035:2066	a liquid to semisolid transition	2035:2066	The enhanced bioaccumulation provided by thermoresponsive SELPs via a liquid to semisolid transition improved rectal delivery of GM-0111 to mice and radioprotection in a RIP model.
33691185	6	10	theme	glycolic	997:1004	arg1	acid					1006:1009	glycolic acid	997:1009	glycolic acid	997:1009	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	6	10	theme	glycolic	997:1004	arg1	Poly					904:907	Poly	904:907	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers	904:1021	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	7	11	theme	Poloxamer	1103:1111	arg1	compositions					1113:1124	Poloxamer compositions	1103:1124	Poloxamer compositions	1103:1124	Poloxamer compositions released GM-0111 cargo within 1 h, while silk-elastinlike copolymers (SELPs) enabled controlled release over a period of 12 h. Bioaccumulation was evaluated using fluorescence imaging and confocal microscopy.
33691185	9	12	theme	GM-0111	1523:1529	arg1	compositions					1531:1542	SELP-415K GM-0111 compositions	1513:1542	SELP-415K GM-0111 compositions	1513:1542	SELP-415K GM-0111 compositions were then used to provide localized protection from radiation induced tissue damage in a murine model of RIP.
33691185	12	13	theme	semisolid	2047:2055	arg1	transition					2057:2066	a liquid to semisolid transition	2035:2066	a liquid to semisolid transition	2035:2066	The enhanced bioaccumulation provided by thermoresponsive SELPs via a liquid to semisolid transition improved rectal delivery of GM-0111 to mice and radioprotection in a RIP model.
33691185	6	14	theme	-co-	992:995	arg1	acid					935:938	glycolic acid	926:938	glycolic acid	926:938	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	6	14	theme	-co-	992:995	arg1	acid					1006:1009	glycolic acid	997:1009	glycolic acid	997:1009	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	6	14	theme	-co-	992:995	arg1	glycol					961:966	ethylene glycol	952:966	ethylene glycol	952:966	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	6	14	theme	-co-	992:995	arg1	Poly					904:907	Poly	904:907	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers	904:1021	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	6	14	theme	-co-	992:995	arg1	acid					916:919	lactic acid	909:919	lactic acid	909:919	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	8	15	theme	highest	1481:1487	arg1	bioaccumulation					1496:1510	the highest rectal bioaccumulation	1477:1510	the highest rectal bioaccumulation	1477:1510	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	10	16	theme	Rectal	1654:1659	arg1	delivery					1661:1668	Rectal delivery	1654:1668	Rectal delivery of SAGE using SELP-415K	1654:1692	Rectal delivery of SAGE using SELP-415K significantly reduced behavioral pain responses, and reduced animal mass loss compared to irradiated controls or treatment with traditional delivery approaches.
33691185	5	17	theme	temperature-responsive	747:768	arg1	polymers					770:777	temperature-responsive polymers	747:777	temperature-responsive polymers	747:777	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	2	18	theme	strategies	300:309	arg1	lack					269:272	The lack	265:272	The lack of prophylactic treatment strategies	265:309	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	9	19	from	damage	1621:1626	arg1	protection					1580:1589	localized protection	1570:1589	localized protection from radiation induced tissue damage	1570:1626	SELP-415K GM-0111 compositions were then used to provide localized protection from radiation induced tissue damage in a murine model of RIP.
33691185	10	20	with	controls	1795:1802	arg1	approaches					1843:1852	traditional delivery approaches	1822:1852	traditional delivery approaches	1822:1852	Rectal delivery of SAGE using SELP-415K significantly reduced behavioral pain responses, and reduced animal mass loss compared to irradiated controls or treatment with traditional delivery approaches.
33691185	8	21	with	units	1392:1396	arg1	residues					1432:1439	lysine residues	1425:1439	lysine residues in the monomer repeats	1425:1462	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	7	22	theme	fluorescence	1289:1300	arg1	imaging					1302:1308	fluorescence imaging	1289:1308	fluorescence imaging	1289:1308	Poloxamer compositions released GM-0111 cargo within 1 h, while silk-elastinlike copolymers (SELPs) enabled controlled release over a period of 12 h. Bioaccumulation was evaluated using fluorescence imaging and confocal microscopy.
33691185	2	23	theme	prophylactic	277:288	arg1	strategies					300:309	prophylactic treatment strategies	277:309	prophylactic treatment strategies	277:309	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	9	24	used	used	1554:1557	arg2	compositions					1531:1542	SELP-415K GM-0111 compositions	1513:1542	SELP-415K GM-0111 compositions	1513:1542	SELP-415K GM-0111 compositions were then used to provide localized protection from radiation induced tissue damage in a murine model of RIP.
33691185	10	25	with	treatment	1807:1815	arg1	approaches					1843:1852	traditional delivery approaches	1822:1852	traditional delivery approaches	1822:1852	Rectal delivery of SAGE using SELP-415K significantly reduced behavioral pain responses, and reduced animal mass loss compared to irradiated controls or treatment with traditional delivery approaches.
33691185	4	26	theme	low	563:565	arg1	time					577:580	low residence time	563:580	low residence time in the rectal tissue	563:601	However, low residence time in the rectal tissue limits their utility.
33691185	11	27	dep	showed	1876:1881	arg1	ameliorated					1898:1908	ameliorated	1898:1908	showed RIP injury was ameliorated for animals treated with GM-0111 delivered by SELP-415K	1876:1964	Histological scoring showed RIP injury was ameliorated for animals treated with GM-0111 delivered by SELP-415K.
33691185	5	28	theme	GM-0111	664:670	arg1	delivery					652:659	controlled delivery	641:659	controlled delivery of GM-0111, a SAGE analogue	641:687	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	1	29	theme	adverse	193:199	arg1	event					201:205	a debilitating adverse event	178:205	a debilitating adverse event that occurs commonly during lower abdominal radiotherapy	178:262	Radiation-induced proctitis (RIP) is a debilitating adverse event that occurs commonly during lower abdominal radiotherapy.
33691185	1	29	theme	adverse	193:199	arg1	proctitis					159:167	Radiation-induced proctitis	141:167	Radiation-induced proctitis (RIP)	141:173	Radiation-induced proctitis (RIP) is a debilitating adverse event that occurs commonly during lower abdominal radiotherapy.
33691185	6	30	theme	phase	1045:1049	arg1	separation					1051:1060	macroscopic phase separation	1033:1060	macroscopic phase separation	1033:1060	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	1	31	theme	Radiation-induced	141:157	arg1	RIP					170:172	RIP	170:172	RIP	170:172	Radiation-induced proctitis (RIP) is a debilitating adverse event that occurs commonly during lower abdominal radiotherapy.
33691185	1	31	theme	Radiation-induced	141:157	arg1	proctitis					159:167	Radiation-induced proctitis	141:167	Radiation-induced proctitis (RIP)	141:173	Radiation-induced proctitis (RIP) is a debilitating adverse event that occurs commonly during lower abdominal radiotherapy.
33691185	1	31	theme	Radiation-induced	141:157	arg1	event					201:205	a debilitating adverse event	178:205	a debilitating adverse event that occurs commonly during lower abdominal radiotherapy	178:262	Radiation-induced proctitis (RIP) is a debilitating adverse event that occurs commonly during lower abdominal radiotherapy.
33691185	0	32	theme	induced	122:128	arg1	proctitis					130:138	radiation induced proctitis	112:138	radiation induced proctitis	112:138	Silk-elastinlike copolymers enhance bioaccumulation of semisynthetic glycosaminoglycan ethers for prevention of radiation induced proctitis.
33691185	9	33	theme	radiation	1596:1604	arg1	damage					1621:1626	radiation induced tissue damage	1596:1626	radiation induced tissue damage	1596:1626	SELP-415K GM-0111 compositions were then used to provide localized protection from radiation induced tissue damage in a murine model of RIP.
33691185	2	34	theme	dose-limiting	441:453	arg1	toxicities					455:464	dose-limiting toxicities	441:464	dose-limiting toxicities	441:464	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	0	35	theme	semisynthetic	55:67	arg1	ethers					87:92	semisynthetic glycosaminoglycan ethers	55:92	semisynthetic glycosaminoglycan ethers	55:92	Silk-elastinlike copolymers enhance bioaccumulation of semisynthetic glycosaminoglycan ethers for prevention of radiation induced proctitis.
33691185	9	36	theme	tissue	1614:1619	arg1	damage					1621:1626	radiation induced tissue damage	1596:1626	radiation induced tissue damage	1596:1626	SELP-415K GM-0111 compositions were then used to provide localized protection from radiation induced tissue damage in a murine model of RIP.
33691185	8	37	theme	elastin	1407:1413	arg1	unit					1415:1418	one elastin unit	1403:1418	one elastin unit with lysine residues in the monomer repeats	1403:1462	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	0	38	theme	Silk-elastinlike	0:15	arg1	copolymers					17:26	Silk-elastinlike copolymers	0:26	Silk-elastinlike copolymers	0:26	Silk-elastinlike copolymers enhance bioaccumulation of semisynthetic glycosaminoglycan ethers for prevention of radiation induced proctitis.
33691185	5	39	theme	distinct	794:801	arg1	behaviors					816:824	distinct phase change behaviors	794:824	distinct phase change behaviors	794:824	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	5	39	theme	distinct	794:801	arg1	properties					838:847	mechanical properties	827:847	mechanical properties	827:847	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	5	39	theme	distinct	794:801	arg1	kinetics					861:868	release kinetics	853:868	release kinetics	853:868	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	9	40	theme	murine	1633:1638	arg1	model					1640:1644	a murine model	1631:1644	a murine model of RIP	1631:1651	SELP-415K GM-0111 compositions were then used to provide localized protection from radiation induced tissue damage in a murine model of RIP.
33691185	3	41	theme	Semisynthetic	467:479	arg1	SAGE					507:510	SAGE	507:510	SAGE	507:510	Semisynthetic glycosaminoglycan ethers (SAGE) demonstrate protective effects from RIP.
33691185	3	41	theme	Semisynthetic	467:479	arg1	ethers					499:504	Semisynthetic glycosaminoglycan ethers	467:504	Semisynthetic glycosaminoglycan ethers (SAGE)	467:511	Semisynthetic glycosaminoglycan ethers (SAGE) demonstrate protective effects from RIP.
33691185	10	42	theme	pain	1727:1730	arg1	responses					1732:1740	behavioral pain responses	1716:1740	behavioral pain responses	1716:1740	Rectal delivery of SAGE using SELP-415K significantly reduced behavioral pain responses, and reduced animal mass loss compared to irradiated controls or treatment with traditional delivery approaches.
33691185	6	43	theme	glycolic	926:933	arg1	Poly					904:907	Poly	904:907	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers	904:1021	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	6	43	theme	glycolic	926:933	arg1	acid					935:938	glycolic acid	926:938	glycolic acid	926:938	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	5	44	theme	mechanical	827:836	arg1	behaviors					816:824	distinct phase change behaviors	794:824	distinct phase change behaviors	794:824	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	5	44	theme	mechanical	827:836	arg1	properties					838:847	mechanical properties	827:847	mechanical properties	827:847	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	10	45	theme	mass	1762:1765	arg1	loss					1767:1770	animal mass loss	1755:1770	animal mass loss	1755:1770	Rectal delivery of SAGE using SELP-415K significantly reduced behavioral pain responses, and reduced animal mass loss compared to irradiated controls or treatment with traditional delivery approaches.
33691185	5	46	theme	rectal	880:885	arg1	bioaccumulation					887:901	rectal bioaccumulation	880:901	rectal bioaccumulation	880:901	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	6	47	theme	-co-	921:924	arg1	acid					935:938	glycolic acid	926:938	glycolic acid	926:938	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	6	47	theme	-co-	921:924	arg1	acid					1006:1009	glycolic acid	997:1009	glycolic acid	997:1009	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	6	47	theme	-co-	921:924	arg1	glycol					961:966	ethylene glycol	952:966	ethylene glycol	952:966	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	6	47	theme	-co-	921:924	arg1	Poly					904:907	Poly	904:907	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers	904:1021	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	6	47	theme	-co-	921:924	arg1	acid					916:919	lactic acid	909:919	lactic acid	909:919	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	2	48	theme	radiotherapy	370:381	arg1	schedules					383:391	radiotherapy schedules	370:391	radiotherapy schedules	370:391	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	12	49	theme	RIP	2137:2139	arg1	model					2141:2145	a RIP model	2135:2145	a RIP model	2135:2145	The enhanced bioaccumulation provided by thermoresponsive SELPs via a liquid to semisolid transition improved rectal delivery of GM-0111 to mice and radioprotection in a RIP model.
33691185	10	50	theme	behavioral	1716:1725	arg1	responses					1732:1740	behavioral pain responses	1716:1740	behavioral pain responses	1716:1740	Rectal delivery of SAGE using SELP-415K significantly reduced behavioral pain responses, and reduced animal mass loss compared to irradiated controls or treatment with traditional delivery approaches.
33691185	2	51	theme	radiotherapy	412:423	arg1	efficacy					425:432	radiotherapy efficacy	412:432	radiotherapy efficacy	412:432	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	6	52	theme	lactic	980:985	arg1	acid					987:990	lactic acid	980:990	lactic acid	980:990	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	7	53	theme	silk-elastinlike	1167:1182	arg1	SELPs					1196:1200	SELPs	1196:1200	SELPs	1196:1200	Poloxamer compositions released GM-0111 cargo within 1 h, while silk-elastinlike copolymers (SELPs) enabled controlled release over a period of 12 h. Bioaccumulation was evaluated using fluorescence imaging and confocal microscopy.
33691185	7	53	theme	silk-elastinlike	1167:1182	arg1	copolymers					1184:1193	silk-elastinlike copolymers	1167:1193	silk-elastinlike copolymers (SELPs) enabled controlled release over a period of 12 h. Bioaccumulation	1167:1267	Poloxamer compositions released GM-0111 cargo within 1 h, while silk-elastinlike copolymers (SELPs) enabled controlled release over a period of 12 h. Bioaccumulation was evaluated using fluorescence imaging and confocal microscopy.
33691185	6	54	theme	Poly	904:907	arg1	copolymers					1012:1021	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers	904:1021	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers	904:1021	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	9	55	theme	localized	1570:1578	arg1	protection					1580:1589	localized protection	1570:1589	localized protection from radiation induced tissue damage	1570:1626	SELP-415K GM-0111 compositions were then used to provide localized protection from radiation induced tissue damage in a murine model of RIP.
33691185	2	56	theme	diminished	320:329	arg1	quality					339:345	diminished patient quality	320:345	diminished patient quality of life	320:353	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	0	57	theme	glycosaminoglycan	69:85	arg1	ethers					87:92	semisynthetic glycosaminoglycan ethers	55:92	semisynthetic glycosaminoglycan ethers	55:92	Silk-elastinlike copolymers enhance bioaccumulation of semisynthetic glycosaminoglycan ethers for prevention of radiation induced proctitis.
33691185	5	58	theme	demonstrated	694:705	arg1	efficacy					707:714	demonstrated efficacy	694:714	demonstrated efficacy against RIP	694:726	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	11	59	theme	RIP	1883:1885	arg1	injury					1887:1892	RIP injury	1883:1892	RIP injury	1883:1892	Histological scoring showed RIP injury was ameliorated for animals treated with GM-0111 delivered by SELP-415K.
33691185	5	60	theme	polymers	770:777	arg1	series					737:742	a series	735:742	a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation	735:901	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	2	61	theme	life	350:353	arg1	limitation					398:407	limitation	398:407	limitation of radiotherapy efficacy	398:432	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	2	61	theme	life	350:353	arg1	quality					339:345	diminished patient quality	320:345	diminished patient quality of life	320:353	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	2	61	theme	life	350:353	arg1	disruption					356:365	disruption	356:365	disruption of radiotherapy schedules	356:391	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	12	62	theme	rectal	2077:2082	arg1	delivery					2084:2091	rectal delivery	2077:2091	rectal delivery of GM-0111 to mice and radioprotection	2077:2130	The enhanced bioaccumulation provided by thermoresponsive SELPs via a liquid to semisolid transition improved rectal delivery of GM-0111 to mice and radioprotection in a RIP model.
33691185	10	63	theme	SAGE	1673:1676	arg1	delivery					1661:1668	Rectal delivery	1654:1668	Rectal delivery of SAGE using SELP-415K	1654:1692	Rectal delivery of SAGE using SELP-415K significantly reduced behavioral pain responses, and reduced animal mass loss compared to irradiated controls or treatment with traditional delivery approaches.
33691185	10	64	theme	animal	1755:1760	arg1	loss					1767:1770	animal mass loss	1755:1770	animal mass loss	1755:1770	Rectal delivery of SAGE using SELP-415K significantly reduced behavioral pain responses, and reduced animal mass loss compared to irradiated controls or treatment with traditional delivery approaches.
33691185	1	65	theme	abdominal	241:249	arg1	radiotherapy					251:262	lower abdominal radiotherapy	235:262	lower abdominal radiotherapy	235:262	Radiation-induced proctitis (RIP) is a debilitating adverse event that occurs commonly during lower abdominal radiotherapy.
33691185	8	66	theme	rectal	1489:1494	arg1	bioaccumulation					1496:1510	the highest rectal bioaccumulation	1477:1510	the highest rectal bioaccumulation	1477:1510	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	7	67	theme	12 h.	1247:1251	arg1	Bioaccumulation					1253:1267	12 h. Bioaccumulation	1247:1267	12 h. Bioaccumulation	1247:1267	Poloxamer compositions released GM-0111 cargo within 1 h, while silk-elastinlike copolymers (SELPs) enabled controlled release over a period of 12 h. Bioaccumulation was evaluated using fluorescence imaging and confocal microscopy.
33691185	8	68	theme	SELP	1348:1351	arg1	SELP-415K					1335:1343	SELP-415K	1335:1343	SELP-415K	1335:1343	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	8	68	theme	SELP	1348:1351	arg1	analogue					1353:1360	a SELP analogue	1346:1360	a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats	1346:1462	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	10	69	theme	delivery	1834:1841	arg1	approaches					1843:1852	traditional delivery approaches	1822:1852	traditional delivery approaches	1822:1852	Rectal delivery of SAGE using SELP-415K significantly reduced behavioral pain responses, and reduced animal mass loss compared to irradiated controls or treatment with traditional delivery approaches.
33691185	2	70	theme	treatment	290:298	arg1	strategies					300:309	prophylactic treatment strategies	277:309	prophylactic treatment strategies	277:309	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	4	71	theme	residence	567:575	arg1	time					577:580	low residence time	563:580	low residence time in the rectal tissue	563:601	However, low residence time in the rectal tissue limits their utility.
33691185	8	72	theme	silk	1369:1372	arg1	units					1374:1378	4 silk units	1367:1378	4 silk units	1367:1378	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	7	73	theme	Bioaccumulation	1253:1267	arg1	period					1237:1242	a period	1235:1242	a period of 12 h. Bioaccumulation	1235:1267	Poloxamer compositions released GM-0111 cargo within 1 h, while silk-elastinlike copolymers (SELPs) enabled controlled release over a period of 12 h. Bioaccumulation was evaluated using fluorescence imaging and confocal microscopy.
33691185	0	74	theme	radiation	112:120	arg1	proctitis					130:138	radiation induced proctitis	112:138	radiation induced proctitis	112:138	Silk-elastinlike copolymers enhance bioaccumulation of semisynthetic glycosaminoglycan ethers for prevention of radiation induced proctitis.
33691185	12	75	theme	thermoresponsive	2008:2023	arg1	SELPs					2025:2029	thermoresponsive SELPs	2008:2029	thermoresponsive SELPs	2008:2029	The enhanced bioaccumulation provided by thermoresponsive SELPs via a liquid to semisolid transition improved rectal delivery of GM-0111 to mice and radioprotection in a RIP model.
33691185	1	76	theme	debilitating	180:191	arg1	event					201:205	a debilitating adverse event	178:205	a debilitating adverse event that occurs commonly during lower abdominal radiotherapy	178:262	Radiation-induced proctitis (RIP) is a debilitating adverse event that occurs commonly during lower abdominal radiotherapy.
33691185	1	76	theme	debilitating	180:191	arg1	proctitis					159:167	Radiation-induced proctitis	141:167	Radiation-induced proctitis (RIP)	141:173	Radiation-induced proctitis (RIP) is a debilitating adverse event that occurs commonly during lower abdominal radiotherapy.
33691185	8	77	with	unit	1415:1418	arg1	residues					1432:1439	lysine residues	1425:1439	lysine residues in the monomer repeats	1425:1462	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	0	78	theme	proctitis	130:138	arg1	prevention					98:107	prevention	98:107	prevention of radiation induced proctitis	98:138	Silk-elastinlike copolymers enhance bioaccumulation of semisynthetic glycosaminoglycan ethers for prevention of radiation induced proctitis.
33691185	6	79	theme	macroscopic	1033:1043	arg1	separation					1051:1060	macroscopic phase separation	1033:1060	macroscopic phase separation	1033:1060	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	8	80	theme	elastin	1384:1390	arg1	units					1392:1396	15 elastin units	1381:1396	15 elastin units	1381:1396	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	5	81	theme	change	809:814	arg1	behaviors					816:824	distinct phase change behaviors	794:824	distinct phase change behaviors	794:824	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	5	81	theme	change	809:814	arg1	properties					838:847	mechanical properties	827:847	mechanical properties	827:847	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	5	81	theme	change	809:814	arg1	kinetics					861:868	release kinetics	853:868	release kinetics	853:868	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	12	82	theme	enhanced	1971:1978	arg1	bioaccumulation					1980:1994	The enhanced bioaccumulation	1967:1994	The enhanced bioaccumulation provided by thermoresponsive SELPs via a liquid to semisolid transition	1967:2066	The enhanced bioaccumulation provided by thermoresponsive SELPs via a liquid to semisolid transition improved rectal delivery of GM-0111 to mice and radioprotection in a RIP model.
33691185	5	83	theme	SAGE	675:678	arg1	analogue					680:687	a SAGE analogue	673:687	a SAGE analogue	673:687	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	5	83	theme	SAGE	675:678	arg1	GM-0111					664:670	GM-0111	664:670	GM-0111	664:670	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	9	84	theme	induced	1606:1612	arg1	damage					1621:1626	radiation induced tissue damage	1596:1626	radiation induced tissue damage	1596:1626	SELP-415K GM-0111 compositions were then used to provide localized protection from radiation induced tissue damage in a murine model of RIP.
33691185	5	85	theme	controlled	641:650	arg1	delivery					652:659	controlled delivery	641:659	controlled delivery of GM-0111, a SAGE analogue	641:687	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	12	86	dep	transition	2057:2066	arg1	to					2044:2045	to	2044:2045	to	2044:2045	The enhanced bioaccumulation provided by thermoresponsive SELPs via a liquid to semisolid transition improved rectal delivery of GM-0111 to mice and radioprotection in a RIP model.
33691185	2	87	theme	efficacy	425:432	arg1	limitation					398:407	limitation	398:407	limitation of radiotherapy efficacy	398:432	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	2	87	theme	efficacy	425:432	arg1	quality					339:345	diminished patient quality	320:345	diminished patient quality of life	320:353	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	2	87	theme	efficacy	425:432	arg1	disruption					356:365	disruption	356:365	disruption of radiotherapy schedules	356:391	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	7	88	theme	controlled	1211:1220	arg1	release					1222:1228	controlled release	1211:1228	controlled release	1211:1228	Poloxamer compositions released GM-0111 cargo within 1 h, while silk-elastinlike copolymers (SELPs) enabled controlled release over a period of 12 h. Bioaccumulation was evaluated using fluorescence imaging and confocal microscopy.
33691185	10	89	theme	irradiated	1784:1793	arg1	controls					1795:1802	irradiated controls	1784:1802	irradiated controls	1784:1802	Rectal delivery of SAGE using SELP-415K significantly reduced behavioral pain responses, and reduced animal mass loss compared to irradiated controls or treatment with traditional delivery approaches.
33691185	5	90	theme	release	853:859	arg1	behaviors					816:824	distinct phase change behaviors	794:824	distinct phase change behaviors	794:824	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	5	90	theme	release	853:859	arg1	kinetics					861:868	release kinetics	853:868	release kinetics	853:868	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	9	91	theme	SELP-415K	1513:1521	arg1	compositions					1531:1542	SELP-415K GM-0111 compositions	1513:1542	SELP-415K GM-0111 compositions	1513:1542	SELP-415K GM-0111 compositions were then used to provide localized protection from radiation induced tissue damage in a murine model of RIP.
33691185	6	92	theme	drug	1081:1084	arg1	drug					1081:1084	drug	1081:1084	drug	1081:1084	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	6	92	theme	drug	1081:1084	arg1	%					1076:1076	>50%	1073:1076	>50% of drug	1073:1084	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	3	93	theme	glycosaminoglycan	481:497	arg1	SAGE					507:510	SAGE	507:510	SAGE	507:510	Semisynthetic glycosaminoglycan ethers (SAGE) demonstrate protective effects from RIP.
33691185	3	93	theme	glycosaminoglycan	481:497	arg1	ethers					499:504	Semisynthetic glycosaminoglycan ethers	467:504	Semisynthetic glycosaminoglycan ethers (SAGE)	467:511	Semisynthetic glycosaminoglycan ethers (SAGE) demonstrate protective effects from RIP.
33691185	4	94	theme	rectal	589:594	arg1	tissue					596:601	the rectal tissue	585:601	the rectal tissue	585:601	However, low residence time in the rectal tissue limits their utility.
33691185	8	95	with	analogue	1353:1360	arg1	units					1374:1378	4 silk units	1367:1378	4 silk units	1367:1378	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	8	95	with	analogue	1353:1360	arg1	unit					1415:1418	one elastin unit	1403:1418	one elastin unit with lysine residues in the monomer repeats	1403:1462	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	8	95	with	analogue	1353:1360	arg1	units					1392:1396	15 elastin units	1381:1396	15 elastin units	1381:1396	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	8	96	theme	lysine	1425:1430	arg1	residues					1432:1439	lysine residues	1425:1439	lysine residues in the monomer repeats	1425:1462	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	3	97	theme	protective	525:534	arg1	effects					536:542	protective effects	525:542	protective effects	525:542	Semisynthetic glycosaminoglycan ethers (SAGE) demonstrate protective effects from RIP.
33691185	0	98	theme	ethers	87:92	arg1	bioaccumulation					36:50	bioaccumulation	36:50	bioaccumulation of semisynthetic glycosaminoglycan ethers for prevention of radiation induced proctitis	36:138	Silk-elastinlike copolymers enhance bioaccumulation of semisynthetic glycosaminoglycan ethers for prevention of radiation induced proctitis.
33691185	9	99	theme	RIP	1649:1651	arg1	model					1640:1644	a murine model	1631:1644	a murine model of RIP	1631:1651	SELP-415K GM-0111 compositions were then used to provide localized protection from radiation induced tissue damage in a murine model of RIP.
33691185	2	100	theme	schedules	383:391	arg1	limitation					398:407	limitation	398:407	limitation of radiotherapy efficacy	398:432	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	2	100	theme	schedules	383:391	arg1	quality					339:345	diminished patient quality	320:345	diminished patient quality of life	320:353	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	2	100	theme	schedules	383:391	arg1	disruption					356:365	disruption	356:365	disruption of radiotherapy schedules	356:391	The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities.
33691185	8	101	with	units	1374:1378	arg1	residues					1432:1439	lysine residues	1425:1439	lysine residues in the monomer repeats	1425:1462	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	8	102	theme	monomer	1448:1454	arg1	repeats					1456:1462	the monomer repeats	1444:1462	the monomer repeats	1444:1462	SELP-415K, a SELP analogue with 4 silk units, 15 elastin units, and one elastin unit with lysine residues in the monomer repeats, resulted in the highest rectal bioaccumulation.
33691185	5	103	theme	phase	803:807	arg1	behaviors					816:824	distinct phase change behaviors	794:824	distinct phase change behaviors	794:824	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	5	103	theme	phase	803:807	arg1	properties					838:847	mechanical properties	827:847	mechanical properties	827:847	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	5	103	theme	phase	803:807	arg1	kinetics					861:868	release kinetics	853:868	release kinetics	853:868	We investigated controlled delivery of GM-0111, a SAGE analogue with demonstrated efficacy against RIP, using a series of temperature-responsive polymers to compare how distinct phase change behaviors, mechanical properties and release kinetics influence rectal bioaccumulation.
33691185	6	104	theme	lactic	909:914	arg1	Poly					904:907	Poly	904:907	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers	904:1021	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	6	104	theme	lactic	909:914	arg1	acid					916:919	lactic acid	909:919	lactic acid	909:919	Poly(lactic acid)-co-(glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid)-co-(glycolic acid) copolymers underwent macroscopic phase separation, expelling >50% of drug during gelation.
33691185	7	105	theme	confocal	1314:1321	arg1	microscopy					1323:1332	confocal microscopy	1314:1332	confocal microscopy	1314:1332	Poloxamer compositions released GM-0111 cargo within 1 h, while silk-elastinlike copolymers (SELPs) enabled controlled release over a period of 12 h. Bioaccumulation was evaluated using fluorescence imaging and confocal microscopy.
33955068	5	0	theme	attractive	911:920	arg1	interactions					936:947	attractive van der Waals interactions	911:947	attractive van der Waals interactions between the CNCs	911:964	The denser packing is demonstrated by N2 adsorption, water uptake, thermoporometry, and small-angle X-ray scattering, and hypothetically assigned to attractive van der Waals interactions between the CNCs.
33955068	2	1	dep	rod-like	282:289	arg1	derived					305:311	derived	305:311	derived	305:311	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	4	2	from	microfibrils	625:636	arg1	fiber					645:649	the fiber	641:649	the fiber	641:649	Upon hydrolysis, cellulose microfibrils in the fiber break down to CNCs that then pack together, resulting in reduced pore size distribution of the original fiber.
33955068	5	3	theme	small-angle	850:860	arg1	scattering					868:877	small-angle X-ray scattering	850:877	small-angle X-ray scattering	850:877	The denser packing is demonstrated by N2 adsorption, water uptake, thermoporometry, and small-angle X-ray scattering, and hypothetically assigned to attractive van der Waals interactions between the CNCs.
33955068	0	4	theme	Fiber	96:100	arg1	Wall					107:110	a Processed Fiber Cell Wall	84:110	a Processed Fiber Cell Wall	84:110	Directed Assembly of Cellulose Nanocrystals in Their Native Solid-State Template of a Processed Fiber Cell Wall.
33955068	5	5	theme	van	922:924	arg1	interactions					936:947	attractive van der Waals interactions	911:947	attractive van der Waals interactions between the CNCs	911:964	The denser packing is demonstrated by N2 adsorption, water uptake, thermoporometry, and small-angle X-ray scattering, and hypothetically assigned to attractive van der Waals interactions between the CNCs.
33955068	2	6	theme	rod-like	282:289	arg1	CNCs					337:340	CNCs	337:340	CNCs	337:340	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	2	6	theme	rod-like	282:289	arg1	nanocrystals					323:334	rod-like, biologically derived cellulose nanocrystals	282:334	rod-like, biologically derived cellulose nanocrystals (CNCs)	282:341	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	0	7	theme	Processed	86:94	arg1	Wall					107:110	a Processed Fiber Cell Wall	84:110	a Processed Fiber Cell Wall	84:110	Directed Assembly of Cellulose Nanocrystals in Their Native Solid-State Template of a Processed Fiber Cell Wall.
33955068	5	8	theme	water	815:819	arg1	uptake					821:826	water uptake	815:826	water uptake	815:826	The denser packing is demonstrated by N2 adsorption, water uptake, thermoporometry, and small-angle X-ray scattering, and hypothetically assigned to attractive van der Waals interactions between the CNCs.
33955068	0	9	theme	Wall	107:110	arg1	Template					72:79	Their Native Solid-State Template	47:79	Their Native Solid-State Template of a Processed Fiber Cell Wall	47:110	Directed Assembly of Cellulose Nanocrystals in Their Native Solid-State Template of a Processed Fiber Cell Wall.
33955068	2	10	theme	fiber	385:389	arg1	wall					396:399	a processed cotton fiber cell wall	366:399	a processed cotton fiber cell wall	366:399	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	2	10	theme	fiber	385:389	arg1	origin					422:427	the native origin	411:427	the native origin of CNCs	411:435	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	0	11	theme	Cell	102:105	arg1	Wall					107:110	a Processed Fiber Cell Wall	84:110	a Processed Fiber Cell Wall	84:110	Directed Assembly of Cellulose Nanocrystals in Their Native Solid-State Template of a Processed Fiber Cell Wall.
33955068	2	12	theme	directed	261:268	arg1	assembly					270:277	directed assembly	261:277	directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs,	261:436	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	1	13	theme	numerous	172:179	arg1	applications					181:192	the numerous applications	168:192	the numerous applications within fields such as catalysis, batteries, and biomedicine	168:252	Nanoparticle assembly is intensely surveyed because of the numerous applications within fields such as catalysis, batteries, and biomedicine.
33955068	2	14	theme	native	415:420	arg1	wall					396:399	a processed cotton fiber cell wall	366:399	a processed cotton fiber cell wall	366:399	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	2	14	theme	native	415:420	arg1	origin					422:427	the native origin	411:427	the native origin of CNCs	411:435	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	2	15	theme	cellulose	313:321	arg1	CNCs					337:340	CNCs	337:340	CNCs	337:340	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	2	15	theme	cellulose	313:321	arg1	nanocrystals					323:334	rod-like, biologically derived cellulose nanocrystals	282:334	rod-like, biologically derived cellulose nanocrystals (CNCs)	282:341	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	2	16	theme	processed	368:376	arg1	wall					396:399	a processed cotton fiber cell wall	366:399	a processed cotton fiber cell wall	366:399	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	2	16	theme	processed	368:376	arg1	origin					422:427	the native origin	411:427	the native origin of CNCs	411:435	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	5	17	theme	X-ray	862:866	arg1	scattering					868:877	small-angle X-ray scattering	850:877	small-angle X-ray scattering	850:877	The denser packing is demonstrated by N2 adsorption, water uptake, thermoporometry, and small-angle X-ray scattering, and hypothetically assigned to attractive van der Waals interactions between the CNCs.
33955068	3	18	with	hydrolysis	571:580	arg1	vapor					591:595	HCl vapor	587:595	HCl vapor	587:595	It is a system where the assembly takes place in solid state simultaneously with the top-down formation of the CNCs via hydrolysis with HCl vapor.
33955068	5	19	theme	N2	800:801	arg1	adsorption					803:812	N2 adsorption	800:812	N2 adsorption	800:812	The denser packing is demonstrated by N2 adsorption, water uptake, thermoporometry, and small-angle X-ray scattering, and hypothetically assigned to attractive van der Waals interactions between the CNCs.
33955068	0	20	theme	Cellulose	21:29	arg1	Nanocrystals					31:42	Cellulose Nanocrystals	21:42	Cellulose Nanocrystals	21:42	Directed Assembly of Cellulose Nanocrystals in Their Native Solid-State Template of a Processed Fiber Cell Wall.
33955068	3	21	theme	HCl	587:589	arg1	vapor					591:595	HCl vapor	587:595	HCl vapor	587:595	It is a system where the assembly takes place in solid state simultaneously with the top-down formation of the CNCs via hydrolysis with HCl vapor.
33955068	3	22	theme	solid	500:504	arg1	state					506:510	solid state	500:510	solid state	500:510	It is a system where the assembly takes place in solid state simultaneously with the top-down formation of the CNCs via hydrolysis with HCl vapor.
33955068	5	23	theme	denser	766:771	arg1	packing					773:779	The denser packing	762:779	The denser packing	762:779	The denser packing is demonstrated by N2 adsorption, water uptake, thermoporometry, and small-angle X-ray scattering, and hypothetically assigned to attractive van der Waals interactions between the CNCs.
33955068	3	24	theme	top-down	536:543	arg1	formation					545:553	the top-down formation	532:553	the top-down formation of the CNCs via hydrolysis with HCl vapor	532:595	It is a system where the assembly takes place in solid state simultaneously with the top-down formation of the CNCs via hydrolysis with HCl vapor.
33955068	2	25	theme	wall	396:399	arg1	template					354:361	the template	350:361	the template of a processed cotton fiber cell wall, that is, the native origin of CNCs,	350:436	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	2	26	theme	CNCs	432:435	arg1	wall					396:399	a processed cotton fiber cell wall	366:399	a processed cotton fiber cell wall	366:399	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	2	26	theme	CNCs	432:435	arg1	origin					422:427	the native origin	411:427	the native origin of CNCs	411:435	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	0	27	theme	Nanocrystals	31:42	arg1	Assembly					9:16	Assembly	9:16	Assembly of Cellulose Nanocrystals	9:42	Directed Assembly of Cellulose Nanocrystals in Their Native Solid-State Template of a Processed Fiber Cell Wall.
33955068	2	28	theme	cell	391:394	arg1	wall					396:399	a processed cotton fiber cell wall	366:399	a processed cotton fiber cell wall	366:399	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	2	28	theme	cell	391:394	arg1	origin					422:427	the native origin	411:427	the native origin of CNCs	411:435	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	0	29	theme	Native	53:58	arg1	Template					72:79	Their Native Solid-State Template	47:79	Their Native Solid-State Template of a Processed Fiber Cell Wall	47:110	Directed Assembly of Cellulose Nanocrystals in Their Native Solid-State Template of a Processed Fiber Cell Wall.
33955068	4	30	theme	fiber	755:759	arg1	distribution					726:737	reduced pore size distribution	708:737	reduced pore size distribution of the original fiber	708:759	Upon hydrolysis, cellulose microfibrils in the fiber break down to CNCs that then pack together, resulting in reduced pore size distribution of the original fiber.
33955068	4	31	theme	original	746:753	arg1	fiber					755:759	the original fiber	742:759	the original fiber	742:759	Upon hydrolysis, cellulose microfibrils in the fiber break down to CNCs that then pack together, resulting in reduced pore size distribution of the original fiber.
33955068	1	32	theme	Nanoparticle	113:124	arg1	assembly					126:133	Nanoparticle assembly	113:133	Nanoparticle assembly	113:133	Nanoparticle assembly is intensely surveyed because of the numerous applications within fields such as catalysis, batteries, and biomedicine.
33955068	5	33	theme	Waals	930:934	arg1	interactions					936:947	attractive van der Waals interactions	911:947	attractive van der Waals interactions between the CNCs	911:964	The denser packing is demonstrated by N2 adsorption, water uptake, thermoporometry, and small-angle X-ray scattering, and hypothetically assigned to attractive van der Waals interactions between the CNCs.
33955068	4	34	theme	pore	716:719	arg1	distribution					726:737	reduced pore size distribution	708:737	reduced pore size distribution of the original fiber	708:759	Upon hydrolysis, cellulose microfibrils in the fiber break down to CNCs that then pack together, resulting in reduced pore size distribution of the original fiber.
33955068	3	35	theme	CNCs	562:565	arg1	formation					545:553	the top-down formation	532:553	the top-down formation of the CNCs via hydrolysis with HCl vapor	532:595	It is a system where the assembly takes place in solid state simultaneously with the top-down formation of the CNCs via hydrolysis with HCl vapor.
33955068	4	36	theme	reduced	708:714	arg1	distribution					726:737	reduced pore size distribution	708:737	reduced pore size distribution of the original fiber	708:759	Upon hydrolysis, cellulose microfibrils in the fiber break down to CNCs that then pack together, resulting in reduced pore size distribution of the original fiber.
33955068	2	37	theme	nanocrystals	323:334	arg1	assembly					270:277	directed assembly	261:277	directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs,	261:436	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	5	38	theme	der	926:928	arg1	interactions					936:947	attractive van der Waals interactions	911:947	attractive van der Waals interactions between the CNCs	911:964	The denser packing is demonstrated by N2 adsorption, water uptake, thermoporometry, and small-angle X-ray scattering, and hypothetically assigned to attractive van der Waals interactions between the CNCs.
33955068	2	39	theme	cotton	378:383	arg1	wall					396:399	a processed cotton fiber cell wall	366:399	a processed cotton fiber cell wall	366:399	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	2	39	theme	cotton	378:383	arg1	origin					422:427	the native origin	411:427	the native origin of CNCs	411:435	Here, directed assembly of rod-like, biologically derived cellulose nanocrystals (CNCs) within the template of a processed cotton fiber cell wall, that is, the native origin of CNCs, is reported.
33955068	0	40	theme	Solid-State	60:70	arg1	Template					72:79	Their Native Solid-State Template	47:79	Their Native Solid-State Template of a Processed Fiber Cell Wall	47:110	Directed Assembly of Cellulose Nanocrystals in Their Native Solid-State Template of a Processed Fiber Cell Wall.
33955068	4	41	theme	size	721:724	arg1	distribution					726:737	reduced pore size distribution	708:737	reduced pore size distribution of the original fiber	708:759	Upon hydrolysis, cellulose microfibrils in the fiber break down to CNCs that then pack together, resulting in reduced pore size distribution of the original fiber.
33955068	4	42	theme	cellulose	615:623	arg1	microfibrils					625:636	cellulose microfibrils	615:636	cellulose microfibrils in the fiber	615:649	Upon hydrolysis, cellulose microfibrils in the fiber break down to CNCs that then pack together, resulting in reduced pore size distribution of the original fiber.
35181070	7	0	dep	dominated	1139:1147	arg1	model					1070:1074	The model	1066:1074	The model described the observations well	1066:1106	The model described the observations well: the final viscosity is mostly dominated by the starch content; protein content has only a marginal impact; and dietary fibre contributes to viscosity with an antagonistic effect with starch.
35181070	9	1	theme	only	1648:1651	arg1	isolates					1653:1660	only isolates	1648:1660	only isolates	1648:1660	An evaluation of the global warming potential of all blends showed that the desired viscosity could be achieved using only isolates, as well as by using only mildly refined fractions.
35181070	8	2	theme	further	1350:1356	arg1	optimisation					1370:1381	further formulation optimisation	1350:1381	further formulation optimisation	1350:1381	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	1	3	theme	food	180:183	arg1	products					185:192	food products	180:192	food products using highly refined techno-functional ingredients of high purity	180:258	Currently, food industries typically favour formulation of food products using highly refined techno-functional ingredients of high purity.
35181070	11	4	theme	alternative	1924:1934	arg1	formulations					1944:1955	alternative product formulations	1924:1955	alternative product formulations	1924:1955	This case study demonstrates the proof of concept for this approach, showing it can aid in identifying alternative product formulations with similar techno-functional properties but with a higher sustainability.
35181070	5	5	theme	functionality-driven	702:721	arg1	formulation					731:741	The functionality-driven product formulation	698:741	The functionality-driven product formulation	698:741	The functionality-driven product formulation is explored through a case study in which yellow pea ingredients are selected to increase the viscosity of a salad dressing.
35181070	1	6	theme	products	185:192	arg1	formulation					165:175	formulation	165:175	formulation of food products using highly refined techno-functional ingredients of high purity	165:258	Currently, food industries typically favour formulation of food products using highly refined techno-functional ingredients of high purity.
35181070	8	7	theme	final	1513:1517	arg1	viscosity					1519:1527	the target final viscosity	1502:1527	the target final viscosity	1502:1527	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	2	8	with	ingredients	329:339	arg1	degree					354:359	a lower degree	346:359	a lower degree of refining as they deliver the same functional properties with reduced environmental impact	346:452	However, there is a growing interest in less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact.
35181070	5	9	theme	yellow	785:790	arg1	ingredients					796:806	yellow pea ingredients	785:806	yellow pea ingredients	785:806	The functionality-driven product formulation is explored through a case study in which yellow pea ingredients are selected to increase the viscosity of a salad dressing.
35181070	6	10	theme	fibre	947:951	arg1	terms					909:913	terms	909:913	terms of composition; protein, starch fibre, and a residual fraction	909:976	The relation between the ingredients (in terms of composition; protein, starch fibre, and a residual fraction) and the final viscosity was quantified and validated using multiple linear regression.
35181070	5	11	theme	product	723:729	arg1	formulation					731:741	The functionality-driven product formulation	698:741	The functionality-driven product formulation	698:741	The functionality-driven product formulation is explored through a case study in which yellow pea ingredients are selected to increase the viscosity of a salad dressing.
35181070	2	12	theme	techno-functional	311:327	arg1	ingredients					329:339	less pure techno-functional ingredients	301:339	less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact	301:452	However, there is a growing interest in less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact.
35181070	5	13	theme	pea	792:794	arg1	ingredients					796:806	yellow pea ingredients	785:806	yellow pea ingredients	785:806	The functionality-driven product formulation is explored through a case study in which yellow pea ingredients are selected to increase the viscosity of a salad dressing.
35181070	7	14	with	effect	1280:1285	arg1	starch					1292:1297	starch	1292:1297	starch	1292:1297	The model described the observations well: the final viscosity is mostly dominated by the starch content; protein content has only a marginal impact; and dietary fibre contributes to viscosity with an antagonistic effect with starch.
35181070	11	15	theme	concept	1863:1869	arg1	proof					1854:1858	the proof	1850:1858	the proof of concept for this approach	1850:1887	This case study demonstrates the proof of concept for this approach, showing it can aid in identifying alternative product formulations with similar techno-functional properties but with a higher sustainability.
35181070	2	16	theme	pure	306:309	arg1	ingredients					329:339	less pure techno-functional ingredients	301:339	less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact	301:452	However, there is a growing interest in less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact.
35181070	8	17	theme	multiple	1313:1320	arg1	model					1340:1344	the multiple linear regression model	1309:1344	the multiple linear regression model	1309:1344	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	4	18	from	shift	625:629	arg1	perspective					634:644	perspective	634:644	perspective	634:644	This article illustrates that the shift in perspective may increase the sustainability of food production.
35181070	9	19	theme	warming	1558:1564	arg1	potential					1566:1574	the global warming potential	1547:1574	the global warming potential of all blends	1547:1588	An evaluation of the global warming potential of all blends showed that the desired viscosity could be achieved using only isolates, as well as by using only mildly refined fractions.
35181070	2	20	theme	reduced	425:431	arg1	impact					447:452	reduced environmental impact	425:452	reduced environmental impact	425:452	However, there is a growing interest in less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact.
35181070	6	21	from	ingredients	893:903	arg1	terms					909:913	terms	909:913	terms of composition; protein, starch fibre, and a residual fraction	909:976	The relation between the ingredients (in terms of composition; protein, starch fibre, and a residual fraction) and the final viscosity was quantified and validated using multiple linear regression.
35181070	6	22	theme	protein	931:937	arg1	terms					909:913	terms	909:913	terms of composition; protein, starch fibre, and a residual fraction	909:976	The relation between the ingredients (in terms of composition; protein, starch fibre, and a residual fraction) and the final viscosity was quantified and validated using multiple linear regression.
35181070	3	23	theme	techno-functional	561:577	arg1	properties					579:588	their techno-functional properties	555:588	their techno-functional properties	555:588	We propose that instead of selecting formulations based on purity, they should be selected based on their techno-functional properties.
35181070	0	24	theme	food	21:24	arg1	formulation					34:44	Functionality-driven food product formulation	0:44	Functionality-driven food product formulation	0:44	Functionality-driven food product formulation - An illustration on selecting sustainable ingredients building viscosity.
35181070	7	25	theme	final	1113:1117	arg1	viscosity					1119:1127	the final viscosity	1109:1127	the final viscosity	1109:1127	The model described the observations well: the final viscosity is mostly dominated by the starch content; protein content has only a marginal impact; and dietary fibre contributes to viscosity with an antagonistic effect with starch.
35181070	7	26	contain	has	1188:1190	arg2	impact					1208:1213	only a marginal impact	1192:1213	only a marginal impact	1192:1213	The model described the observations well: the final viscosity is mostly dominated by the starch content; protein content has only a marginal impact; and dietary fibre contributes to viscosity with an antagonistic effect with starch.
35181070	7	26	contain	has	1188:1190	arg1	content					1180:1186	protein content	1172:1186	protein content	1172:1186	The model described the observations well: the final viscosity is mostly dominated by the starch content; protein content has only a marginal impact; and dietary fibre contributes to viscosity with an antagonistic effect with starch.
35181070	2	27	theme	lower	348:352	arg1	degree					354:359	a lower degree	346:359	a lower degree of refining as they deliver the same functional properties with reduced environmental impact	346:452	However, there is a growing interest in less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact.
35181070	1	28	theme	refined	207:213	arg1	ingredients					233:243	highly refined techno-functional ingredients	200:243	highly refined techno-functional ingredients of high purity	200:258	Currently, food industries typically favour formulation of food products using highly refined techno-functional ingredients of high purity.
35181070	0	29	theme	Functionality-driven	0:19	arg1	formulation					34:44	Functionality-driven food product formulation	0:44	Functionality-driven food product formulation	0:44	Functionality-driven food product formulation - An illustration on selecting sustainable ingredients building viscosity.
35181070	2	30	theme	functional	398:407	arg1	properties					409:418	the same functional properties	389:418	the same functional properties	389:418	However, there is a growing interest in less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact.
35181070	10	31	theme	global	1746:1751	arg1	lower					1783:1787	lower	1783:1787	lower	1783:1787	The latter is associated with a global warming potential that is 80% lower than the one based on isolates.
35181070	10	31	theme	global	1746:1751	arg1	potential					1761:1769	a global warming potential	1744:1769	a global warming potential that is 80% lower than the one based on isolates	1744:1818	The latter is associated with a global warming potential that is 80% lower than the one based on isolates.
35181070	5	32	theme	case	765:768	arg1	study					770:774	a case study	763:774	a case study in which yellow pea ingredients are selected to increase the viscosity of a salad dressing	763:865	The functionality-driven product formulation is explored through a case study in which yellow pea ingredients are selected to increase the viscosity of a salad dressing.
35181070	9	33	theme	blends	1583:1588	arg1	potential					1566:1574	the global warming potential	1547:1574	the global warming potential of all blends	1547:1588	An evaluation of the global warming potential of all blends showed that the desired viscosity could be achieved using only isolates, as well as by using only mildly refined fractions.
35181070	4	34	theme	food	681:684	arg1	production					686:695	food production	681:695	food production	681:695	This article illustrates that the shift in perspective may increase the sustainability of food production.
35181070	0	35	theme	product	26:32	arg1	formulation					34:44	Functionality-driven food product formulation	0:44	Functionality-driven food product formulation	0:44	Functionality-driven food product formulation - An illustration on selecting sustainable ingredients building viscosity.
35181070	6	36	theme	final	987:991	arg1	viscosity					993:1001	the final viscosity	983:1001	the final viscosity	983:1001	The relation between the ingredients (in terms of composition; protein, starch fibre, and a residual fraction) and the final viscosity was quantified and validated using multiple linear regression.
35181070	11	37	theme	similar	1962:1968	arg1	properties					1988:1997	similar techno-functional properties	1962:1997	similar techno-functional properties	1962:1997	This case study demonstrates the proof of concept for this approach, showing it can aid in identifying alternative product formulations with similar techno-functional properties but with a higher sustainability.
35181070	6	38	theme	composition	918:928	arg1	terms					909:913	terms	909:913	terms of composition; protein, starch fibre, and a residual fraction	909:976	The relation between the ingredients (in terms of composition; protein, starch fibre, and a residual fraction) and the final viscosity was quantified and validated using multiple linear regression.
35181070	10	39	theme	warming	1753:1759	arg1	lower					1783:1787	lower	1783:1787	lower	1783:1787	The latter is associated with a global warming potential that is 80% lower than the one based on isolates.
35181070	10	39	theme	warming	1753:1759	arg1	potential					1761:1769	a global warming potential	1744:1769	a global warming potential that is 80% lower than the one based on isolates	1744:1818	The latter is associated with a global warming potential that is 80% lower than the one based on isolates.
35181070	2	40	from	interest	289:296	arg1	ingredients					329:339	less pure techno-functional ingredients	301:339	less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact	301:452	However, there is a growing interest in less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact.
35181070	7	41	theme	antagonistic	1267:1278	arg1	effect					1280:1285	an antagonistic effect	1264:1285	an antagonistic effect with starch	1264:1297	The model described the observations well: the final viscosity is mostly dominated by the starch content; protein content has only a marginal impact; and dietary fibre contributes to viscosity with an antagonistic effect with starch.
35181070	7	42	theme	protein	1172:1178	arg1	content					1180:1186	protein content	1172:1186	protein content	1172:1186	The model described the observations well: the final viscosity is mostly dominated by the starch content; protein content has only a marginal impact; and dietary fibre contributes to viscosity with an antagonistic effect with starch.
35181070	8	43	with	ingredients	1422:1432	arg1	degree					1461:1466	either a high or low degree	1440:1466	degree	1461:1466	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	9	44	theme	refined	1695:1701	arg1	fractions					1703:1711	only mildly refined fractions	1683:1711	only mildly refined fractions	1683:1711	An evaluation of the global warming potential of all blends showed that the desired viscosity could be achieved using only isolates, as well as by using only mildly refined fractions.
35181070	7	45	theme	marginal	1199:1206	arg1	impact					1208:1213	only a marginal impact	1192:1213	only a marginal impact	1192:1213	The model described the observations well: the final viscosity is mostly dominated by the starch content; protein content has only a marginal impact; and dietary fibre contributes to viscosity with an antagonistic effect with starch.
35181070	4	46	theme	production	686:695	arg1	sustainability					663:676	the sustainability	659:676	the sustainability of food production	659:695	This article illustrates that the shift in perspective may increase the sustainability of food production.
35181070	1	47	theme	techno-functional	215:231	arg1	ingredients					233:243	highly refined techno-functional ingredients	200:243	highly refined techno-functional ingredients of high purity	200:258	Currently, food industries typically favour formulation of food products using highly refined techno-functional ingredients of high purity.
35181070	1	48	theme	high	248:251	arg1	purity					253:258	high purity	248:258	high purity	248:258	Currently, food industries typically favour formulation of food products using highly refined techno-functional ingredients of high purity.
35181070	6	49	from	viscosity	993:1001	arg1	terms					909:913	terms	909:913	terms of composition; protein, starch fibre, and a residual fraction	909:976	The relation between the ingredients (in terms of composition; protein, starch fibre, and a residual fraction) and the final viscosity was quantified and validated using multiple linear regression.
35181070	8	50	theme	ingredients	1422:1432	arg1	combinations					1406:1417	various combinations	1398:1417	various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity	1398:1527	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	1	51	theme	purity	253:258	arg1	ingredients					233:243	highly refined techno-functional ingredients	200:243	highly refined techno-functional ingredients of high purity	200:258	Currently, food industries typically favour formulation of food products using highly refined techno-functional ingredients of high purity.
35181070	7	52	theme	starch	1156:1161	arg1	content					1163:1169	the starch content	1152:1169	the starch content	1152:1169	The model described the observations well: the final viscosity is mostly dominated by the starch content; protein content has only a marginal impact; and dietary fibre contributes to viscosity with an antagonistic effect with starch.
35181070	8	53	theme	various	1398:1404	arg1	combinations					1406:1417	various combinations	1398:1417	various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity	1398:1527	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	8	54	theme	refining	1471:1478	arg1	degree					1461:1466	either a high or low degree	1440:1466	degree	1461:1466	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	9	55	theme	desired	1606:1612	arg1	viscosity					1614:1622	the desired viscosity	1602:1622	the desired viscosity	1602:1622	An evaluation of the global warming potential of all blends showed that the desired viscosity could be achieved using only isolates, as well as by using only mildly refined fractions.
35181070	1	56	theme	food	132:135	arg1	industries					137:146	food industries	132:146	food industries	132:146	Currently, food industries typically favour formulation of food products using highly refined techno-functional ingredients of high purity.
35181070	5	57	theme	salad	852:856	arg1	dressing					858:865	a salad dressing	850:865	a salad dressing	850:865	The functionality-driven product formulation is explored through a case study in which yellow pea ingredients are selected to increase the viscosity of a salad dressing.
35181070	6	58	theme	fraction	969:976	arg1	terms					909:913	terms	909:913	terms of composition; protein, starch fibre, and a residual fraction	909:976	The relation between the ingredients (in terms of composition; protein, starch fibre, and a residual fraction) and the final viscosity was quantified and validated using multiple linear regression.
35181070	8	59	dep	degree	1461:1466	arg1	either					1440:1445	either	1440:1445	either	1440:1445	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	11	60	theme	case	1826:1829	arg1	study					1831:1835	This case study	1821:1835	This case study	1821:1835	This case study demonstrates the proof of concept for this approach, showing it can aid in identifying alternative product formulations with similar techno-functional properties but with a higher sustainability.
35181070	9	61	theme	global	1551:1556	arg1	potential					1566:1574	the global warming potential	1547:1574	the global warming potential of all blends	1547:1588	An evaluation of the global warming potential of all blends showed that the desired viscosity could be achieved using only isolates, as well as by using only mildly refined fractions.
35181070	6	62	theme	residual	960:967	arg1	fraction					969:976	a residual fraction	958:976	a residual fraction	958:976	The relation between the ingredients (in terms of composition; protein, starch fibre, and a residual fraction) and the final viscosity was quantified and validated using multiple linear regression.
35181070	8	63	theme	high	1449:1452	arg1	degree					1461:1466	either a high or low degree	1440:1466	degree	1461:1466	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	8	64	theme	linear	1322:1327	arg1	model					1340:1344	the multiple linear regression model	1309:1344	the multiple linear regression model	1309:1344	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	11	65	theme	techno-functional	1970:1986	arg1	properties					1988:1997	similar techno-functional properties	1962:1997	similar techno-functional properties	1962:1997	This case study demonstrates the proof of concept for this approach, showing it can aid in identifying alternative product formulations with similar techno-functional properties but with a higher sustainability.
35181070	9	66	theme	potential	1566:1574	arg1	evaluation					1533:1542	An evaluation	1530:1542	An evaluation of the global warming potential of all blends	1530:1588	An evaluation of the global warming potential of all blends showed that the desired viscosity could be achieved using only isolates, as well as by using only mildly refined fractions.
35181070	2	67	theme	growing	281:287	arg1	interest					289:296	a growing interest	279:296	a growing interest in less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact	279:452	However, there is a growing interest in less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact.
35181070	8	68	theme	regression	1329:1338	arg1	model					1340:1344	the multiple linear regression model	1309:1344	the multiple linear regression model	1309:1344	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	8	69	theme	formulation	1358:1368	arg1	optimisation					1370:1381	further formulation optimisation	1350:1381	further formulation optimisation	1350:1381	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	0	70	theme	sustainable	77:87	arg1	ingredients					89:99	sustainable ingredients	77:99	sustainable ingredients building viscosity	77:118	Functionality-driven food product formulation - An illustration on selecting sustainable ingredients building viscosity.
35181070	2	71	theme	environmental	433:445	arg1	impact					447:452	reduced environmental impact	425:452	reduced environmental impact	425:452	However, there is a growing interest in less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact.
35181070	8	72	theme	low	1457:1459	arg1	degree					1461:1466	either a high or low degree	1440:1466	degree	1461:1466	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	2	73	theme	same	393:396	arg1	properties					409:418	the same functional properties	389:418	the same functional properties	389:418	However, there is a growing interest in less pure techno-functional ingredients with a lower degree of refining as they deliver the same functional properties with reduced environmental impact.
35181070	11	74	theme	higher	2010:2015	arg1	sustainability					2017:2030	a higher sustainability	2008:2030	a higher sustainability	2008:2030	This case study demonstrates the proof of concept for this approach, showing it can aid in identifying alternative product formulations with similar techno-functional properties but with a higher sustainability.
35181070	6	75	theme	linear	1047:1052	arg1	regression					1054:1063	multiple linear regression	1038:1063	multiple linear regression	1038:1063	The relation between the ingredients (in terms of composition; protein, starch fibre, and a residual fraction) and the final viscosity was quantified and validated using multiple linear regression.
35181070	8	76	theme	target	1506:1511	arg1	viscosity					1519:1527	the target final viscosity	1502:1527	the target final viscosity	1502:1527	Based on the multiple linear regression model and further formulation optimisation, we identified various combinations of ingredients (with either a high or low degree of refining) that would result in the target final viscosity.
35181070	11	77	theme	product	1936:1942	arg1	formulations					1944:1955	alternative product formulations	1924:1955	alternative product formulations	1924:1955	This case study demonstrates the proof of concept for this approach, showing it can aid in identifying alternative product formulations with similar techno-functional properties but with a higher sustainability.
35181070	5	78	theme	dressing	858:865	arg1	viscosity					837:845	the viscosity	833:845	the viscosity of a salad dressing	833:865	The functionality-driven product formulation is explored through a case study in which yellow pea ingredients are selected to increase the viscosity of a salad dressing.
35181070	6	79	theme	multiple	1038:1045	arg1	regression					1054:1063	multiple linear regression	1038:1063	multiple linear regression	1038:1063	The relation between the ingredients (in terms of composition; protein, starch fibre, and a residual fraction) and the final viscosity was quantified and validated using multiple linear regression.
33258964	7	0	theme	Squares	1197:1203	arg1	Analysis					1218:1225	Partial Least Squares Discriminant Analysis	1183:1225	Partial Least Squares Discriminant Analysis	1183:1225	We have also demonstrated how the collected data can be efficiently used to observe the relationships between starch parameters and rice cultivars through correlation analysis and Partial Least Squares Discriminant Analysis.
33258964	4	1	theme	rice	657:660	arg1	information					669:679	dispersed rice starch information	647:679	dispersed rice starch information	647:679	The key aim of the ThRSDB is to facilitate accessibility to dispersed rice starch information for, but not limited to, both research and industrial users.
33258964	3	2	from	articles	506:513	arg1	functionality					572:584	functionality	572:584	functionality	572:584	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	2	from	articles	506:513	arg1	composition					535:545	Thai rice starch composition	518:545	Thai rice starch composition	518:545	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	2	from	articles	506:513	arg1	structure					558:566	molecular structure	548:566	molecular structure	548:566	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	0	3	theme	molecular	52:60	arg1	composition					39:49	Thai rice starch composition	22:49	Thai rice starch composition	22:49	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.
33258964	0	3	theme	molecular	52:60	arg1	structure					62:70	molecular structure	52:70	molecular structure	52:70	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.
33258964	4	4	theme	starch	662:667	arg1	information					669:679	dispersed rice starch information	647:679	dispersed rice starch information	647:679	The key aim of the ThRSDB is to facilitate accessibility to dispersed rice starch information for, but not limited to, both research and industrial users.
33258964	7	5	theme	Partial	1183:1189	arg1	Squares					1197:1203	Partial Least Squares	1183:1203	Partial Least Squares Discriminant Analysis	1183:1225	We have also demonstrated how the collected data can be efficiently used to observe the relationships between starch parameters and rice cultivars through correlation analysis and Partial Least Squares Discriminant Analysis.
33258964	3	6	theme	starch	528:533	arg1	functionality					572:584	functionality	572:584	functionality	572:584	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	6	theme	starch	528:533	arg1	composition					535:545	Thai rice starch composition	518:545	Thai rice starch composition	518:545	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	6	theme	starch	528:533	arg1	structure					558:566	molecular structure	548:566	molecular structure	548:566	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	6	7	theme	web	952:954	arg1	interface					956:964	a user-friendly web interface	936:964	a user-friendly web interface	936:964	The ThRSDB includes the search functions necessary for accessing data together with a user-friendly web interface and interactive visualization tools.
33258964	4	8	dep	users	735:739	arg1	both					706:709	both	706:709	both	706:709	The key aim of the ThRSDB is to facilitate accessibility to dispersed rice starch information for, but not limited to, both research and industrial users.
33258964	4	8	dep	users	735:739	arg1	industrial					724:733	industrial	724:733	industrial	724:733	The key aim of the ThRSDB is to facilitate accessibility to dispersed rice starch information for, but not limited to, both research and industrial users.
33258964	7	9	theme	Discriminant	1205:1216	arg1	Analysis					1218:1225	Partial Least Squares Discriminant Analysis	1183:1225	Partial Least Squares Discriminant Analysis	1183:1225	We have also demonstrated how the collected data can be efficiently used to observe the relationships between starch parameters and rice cultivars through correlation analysis and Partial Least Squares Discriminant Analysis.
33258964	3	10	theme	Thai	518:521	arg1	functionality					572:584	functionality	572:584	functionality	572:584	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	10	theme	Thai	518:521	arg1	composition					535:545	Thai rice starch composition	518:545	Thai rice starch composition	518:545	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	10	theme	Thai	518:521	arg1	structure					558:566	molecular structure	548:566	molecular structure	548:566	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	6	11	theme	user-friendly	938:950	arg1	interface					956:964	a user-friendly web interface	936:964	a user-friendly web interface	936:964	The ThRSDB includes the search functions necessary for accessing data together with a user-friendly web interface and interactive visualization tools.
33258964	7	12	used	used	1071:1074	arg2	data					1047:1050	the collected data	1033:1050	the collected data	1033:1050	We have also demonstrated how the collected data can be efficiently used to observe the relationships between starch parameters and rice cultivars through correlation analysis and Partial Least Squares Discriminant Analysis.
33258964	1	13	theme	starch	94:99	arg1	properties					101:110	starch properties	94:110	starch properties	94:110	As starch properties can affect end product quality in many ways, rice starch from Thai domesticated cultivars and landraces has been the focus of increasing research interest.
33258964	5	14	theme	rice	789:792	arg1	cultivars					794:802	191 different Thai rice cultivars	770:802	191 different Thai rice cultivars	770:802	Currently, 373 samples from 191 different Thai rice cultivars have been collected from 39 published articles.
33258964	3	15	theme	research	497:504	arg1	articles					506:513	original research articles	488:513	original research articles on Thai rice starch composition, molecular structure and functionality	488:584	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	1	16	theme	many	146:149	arg1	ways					151:154	many ways	146:154	many ways	146:154	As starch properties can affect end product quality in many ways, rice starch from Thai domesticated cultivars and landraces has been the focus of increasing research interest.
33258964	5	17	theme	373	753:755	arg1	samples					757:763	373 samples	753:763	373 samples from 191 different Thai rice cultivars	753:802	Currently, 373 samples from 191 different Thai rice cultivars have been collected from 39 published articles.
33258964	8	18	theme	Database	1228:1235	arg1	http					1242:1245	Database URL: http	1228:1245	Database URL: http	1228:1245	Database URL: http://thairicestarch.kku.ac.th.
33258964	3	19	contain	containing	447:456	arg1	Database					407:414	The Thai Rice Starch Database	386:414	The Thai Rice Starch Database (ThRSDB)	386:423	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	19	contain	containing	447:456	arg2	data					458:461	data	458:461	data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality	458:584	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	19	contain	containing	447:456	arg1	database					438:445	an online database	428:445	an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality	428:584	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	4	20	dep	both	706:709	arg1	research					711:718	research	711:718	research	711:718	The key aim of the ThRSDB is to facilitate accessibility to dispersed rice starch information for, but not limited to, both research and industrial users.
33258964	3	21	theme	Rice	395:398	arg1	Database					407:414	The Thai Rice Starch Database	386:414	The Thai Rice Starch Database (ThRSDB)	386:423	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	21	theme	Rice	395:398	arg1	database					438:445	an online database	428:445	an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality	428:584	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	21	theme	Rice	395:398	arg1	ThRSDB					417:422	ThRSDB	417:422	ThRSDB	417:422	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	7	22	theme	correlation	1158:1168	arg1	analysis					1170:1177	correlation analysis	1158:1177	correlation analysis	1158:1177	We have also demonstrated how the collected data can be efficiently used to observe the relationships between starch parameters and rice cultivars through correlation analysis and Partial Least Squares Discriminant Analysis.
33258964	8	23	theme	URL	1237:1239	arg1	http					1242:1245	Database URL: http	1228:1245	Database URL: http	1228:1245	Database URL: http://thairicestarch.kku.ac.th.
33258964	1	24	theme	rice	157:160	arg1	focus					229:233	the focus	225:233	the focus of increasing research interest	225:265	As starch properties can affect end product quality in many ways, rice starch from Thai domesticated cultivars and landraces has been the focus of increasing research interest.
33258964	1	24	theme	rice	157:160	arg1	starch					162:167	rice starch	157:167	rice starch from Thai domesticated cultivars and landraces	157:214	As starch properties can affect end product quality in many ways, rice starch from Thai domesticated cultivars and landraces has been the focus of increasing research interest.
33258964	7	25	theme	rice	1135:1138	arg1	cultivars					1140:1148	rice cultivars	1135:1148	rice cultivars	1135:1148	We have also demonstrated how the collected data can be efficiently used to observe the relationships between starch parameters and rice cultivars through correlation analysis and Partial Least Squares Discriminant Analysis.
33258964	1	26	theme	research	249:256	arg1	interest					258:265	research interest	249:265	research interest	249:265	As starch properties can affect end product quality in many ways, rice starch from Thai domesticated cultivars and landraces has been the focus of increasing research interest.
33258964	7	27	theme	collected	1037:1045	arg1	data					1047:1050	the collected data	1033:1050	the collected data	1033:1050	We have also demonstrated how the collected data can be efficiently used to observe the relationships between starch parameters and rice cultivars through correlation analysis and Partial Least Squares Discriminant Analysis.
33258964	3	28	theme	rice	523:526	arg1	functionality					572:584	functionality	572:584	functionality	572:584	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	28	theme	rice	523:526	arg1	composition					535:545	Thai rice starch composition	518:545	Thai rice starch composition	518:545	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	28	theme	rice	523:526	arg1	structure					558:566	molecular structure	548:566	molecular structure	548:566	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	5	29	theme	Thai	784:787	arg1	cultivars					794:802	191 different Thai rice cultivars	770:802	191 different Thai rice cultivars	770:802	Currently, 373 samples from 191 different Thai rice cultivars have been collected from 39 published articles.
33258964	5	30	theme	different	774:782	arg1	cultivars					794:802	191 different Thai rice cultivars	770:802	191 different Thai rice cultivars	770:802	Currently, 373 samples from 191 different Thai rice cultivars have been collected from 39 published articles.
33258964	8	31	dep	//thairicestarch.kku.ac.th	1247:1272	arg1	http					1242:1245	Database URL: http	1228:1245	Database URL: http	1228:1245	Database URL: http://thairicestarch.kku.ac.th.
33258964	2	32	theme	Increasing	268:277	arg1	knowledge					279:287	Increasing knowledge	268:287	Increasing knowledge in this area	268:300	Increasing knowledge in this area creates a high demand from the research community for better organized information.
33258964	1	33	theme	end	123:125	arg1	quality					135:141	end product quality	123:141	end product quality	123:141	As starch properties can affect end product quality in many ways, rice starch from Thai domesticated cultivars and landraces has been the focus of increasing research interest.
33258964	0	34	theme	Thai	22:25	arg1	functionality					76:88	functionality	76:88	functionality	76:88	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.
33258964	0	34	theme	Thai	22:25	arg1	composition					39:49	Thai rice starch composition	22:49	Thai rice starch composition	22:49	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.
33258964	0	34	theme	Thai	22:25	arg1	structure					62:70	molecular structure	52:70	molecular structure	52:70	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.
33258964	3	35	theme	Starch	400:405	arg1	Database					407:414	The Thai Rice Starch Database	386:414	The Thai Rice Starch Database (ThRSDB)	386:423	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	35	theme	Starch	400:405	arg1	database					438:445	an online database	428:445	an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality	428:584	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	35	theme	Starch	400:405	arg1	ThRSDB					417:422	ThRSDB	417:422	ThRSDB	417:422	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	1	36	theme	Thai	174:177	arg1	cultivars					192:200	Thai domesticated cultivars	174:200	Thai domesticated cultivars	174:200	As starch properties can affect end product quality in many ways, rice starch from Thai domesticated cultivars and landraces has been the focus of increasing research interest.
33258964	2	37	theme	organized	363:371	arg1	information					373:383	better organized information	356:383	better organized information	356:383	Increasing knowledge in this area creates a high demand from the research community for better organized information.
33258964	3	38	theme	Thai	390:393	arg1	Database					407:414	The Thai Rice Starch Database	386:414	The Thai Rice Starch Database (ThRSDB)	386:423	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	38	theme	Thai	390:393	arg1	database					438:445	an online database	428:445	an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality	428:584	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	38	theme	Thai	390:393	arg1	ThRSDB					417:422	ThRSDB	417:422	ThRSDB	417:422	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	6	39	theme	interactive	970:980	arg1	tools					996:1000	interactive visualization tools	970:1000	interactive visualization tools	970:1000	The ThRSDB includes the search functions necessary for accessing data together with a user-friendly web interface and interactive visualization tools.
33258964	5	40	from	cultivars	794:802	arg1	samples					757:763	373 samples	753:763	373 samples from 191 different Thai rice cultivars	753:802	Currently, 373 samples from 191 different Thai rice cultivars have been collected from 39 published articles.
33258964	1	41	theme	domesticated	179:190	arg1	cultivars					192:200	Thai domesticated cultivars	174:200	Thai domesticated cultivars	174:200	As starch properties can affect end product quality in many ways, rice starch from Thai domesticated cultivars and landraces has been the focus of increasing research interest.
33258964	0	42	theme	starch	32:37	arg1	functionality					76:88	functionality	76:88	functionality	76:88	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.
33258964	0	42	theme	starch	32:37	arg1	composition					39:49	Thai rice starch composition	22:49	Thai rice starch composition	22:49	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.
33258964	0	42	theme	starch	32:37	arg1	structure					62:70	molecular structure	52:70	molecular structure	52:70	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.
33258964	5	43	theme	published	832:840	arg1	articles					842:849	39 published articles	829:849	39 published articles	829:849	Currently, 373 samples from 191 different Thai rice cultivars have been collected from 39 published articles.
33258964	1	44	from	landraces	206:214	arg1	focus					229:233	the focus	225:233	the focus of increasing research interest	225:265	As starch properties can affect end product quality in many ways, rice starch from Thai domesticated cultivars and landraces has been the focus of increasing research interest.
33258964	1	44	from	landraces	206:214	arg1	starch					162:167	rice starch	157:167	rice starch from Thai domesticated cultivars and landraces	157:214	As starch properties can affect end product quality in many ways, rice starch from Thai domesticated cultivars and landraces has been the focus of increasing research interest.
33258964	3	45	theme	molecular	548:556	arg1	composition					535:545	Thai rice starch composition	518:545	Thai rice starch composition	518:545	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	45	theme	molecular	548:556	arg1	structure					558:566	molecular structure	548:566	molecular structure	548:566	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	2	46	from	community	342:350	arg1	demand					317:322	a high demand	310:322	a high demand from the research community for better organized information	310:383	Increasing knowledge in this area creates a high demand from the research community for better organized information.
33258964	2	47	theme	high	312:315	arg1	demand					317:322	a high demand	310:322	a high demand from the research community for better organized information	310:383	Increasing knowledge in this area creates a high demand from the research community for better organized information.
33258964	0	48	theme	rice	27:30	arg1	functionality					76:88	functionality	76:88	functionality	76:88	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.
33258964	0	48	theme	rice	27:30	arg1	composition					39:49	Thai rice starch composition	22:49	Thai rice starch composition	22:49	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.
33258964	0	48	theme	rice	27:30	arg1	structure					62:70	molecular structure	52:70	molecular structure	52:70	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.
33258964	6	49	theme	necessary	893:901	arg1	functions					883:891	the search functions	872:891	the search functions necessary for accessing data together with a user-friendly web interface and interactive visualization tools	872:1000	The ThRSDB includes the search functions necessary for accessing data together with a user-friendly web interface and interactive visualization tools.
33258964	7	50	theme	Least	1191:1195	arg1	Squares					1197:1203	Partial Least Squares	1183:1203	Partial Least Squares Discriminant Analysis	1183:1225	We have also demonstrated how the collected data can be efficiently used to observe the relationships between starch parameters and rice cultivars through correlation analysis and Partial Least Squares Discriminant Analysis.
33258964	1	51	from	cultivars	192:200	arg1	focus					229:233	the focus	225:233	the focus of increasing research interest	225:265	As starch properties can affect end product quality in many ways, rice starch from Thai domesticated cultivars and landraces has been the focus of increasing research interest.
33258964	1	51	from	cultivars	192:200	arg1	starch					162:167	rice starch	157:167	rice starch from Thai domesticated cultivars and landraces	157:214	As starch properties can affect end product quality in many ways, rice starch from Thai domesticated cultivars and landraces has been the focus of increasing research interest.
33258964	7	52	theme	starch	1113:1118	arg1	parameters					1120:1129	starch parameters	1113:1129	starch parameters	1113:1129	We have also demonstrated how the collected data can be efficiently used to observe the relationships between starch parameters and rice cultivars through correlation analysis and Partial Least Squares Discriminant Analysis.
33258964	4	53	theme	dispersed	647:655	arg1	information					669:679	dispersed rice starch information	647:679	dispersed rice starch information	647:679	The key aim of the ThRSDB is to facilitate accessibility to dispersed rice starch information for, but not limited to, both research and industrial users.
33258964	3	54	theme	online	431:436	arg1	Database					407:414	The Thai Rice Starch Database	386:414	The Thai Rice Starch Database (ThRSDB)	386:423	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	54	theme	online	431:436	arg1	database					438:445	an online database	428:445	an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality	428:584	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	3	55	theme	original	488:495	arg1	articles					506:513	original research articles	488:513	original research articles on Thai rice starch composition, molecular structure and functionality	488:584	The Thai Rice Starch Database (ThRSDB) is an online database containing data extensively curated from original research articles on Thai rice starch composition, molecular structure and functionality.
33258964	4	56	theme	ThRSDB	606:611	arg1	aim					595:597	The key aim	587:597	The key aim of the ThRSDB	587:611	The key aim of the ThRSDB is to facilitate accessibility to dispersed rice starch information for, but not limited to, both research and industrial users.
33258964	2	57	theme	research	333:340	arg1	community					342:350	the research community	329:350	the research community	329:350	Increasing knowledge in this area creates a high demand from the research community for better organized information.
33258964	6	58	theme	visualization	982:994	arg1	tools					996:1000	interactive visualization tools	970:1000	interactive visualization tools	970:1000	The ThRSDB includes the search functions necessary for accessing data together with a user-friendly web interface and interactive visualization tools.
33258964	0	59	theme	composition	39:49	arg1	database					10:17	a database	8:17	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.	0:89	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.
33258964	6	60	theme	search	876:881	arg1	functions					883:891	the search functions	872:891	the search functions necessary for accessing data together with a user-friendly web interface and interactive visualization tools	872:1000	The ThRSDB includes the search functions necessary for accessing data together with a user-friendly web interface and interactive visualization tools.
33258964	0	61	dep	ThRSDB	0:5	arg1	database					10:17	a database	8:17	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.	0:89	ThRSDB: a database of Thai rice starch composition, molecular structure and functionality.
33258964	1	62	theme	product	127:133	arg1	quality					135:141	end product quality	123:141	end product quality	123:141	As starch properties can affect end product quality in many ways, rice starch from Thai domesticated cultivars and landraces has been the focus of increasing research interest.
33258964	2	63	from	knowledge	279:287	arg1	area					297:300	this area	292:300	this area	292:300	Increasing knowledge in this area creates a high demand from the research community for better organized information.
33258964	4	64	theme	key	591:593	arg1	aim					595:597	The key aim	587:597	The key aim of the ThRSDB	587:611	The key aim of the ThRSDB is to facilitate accessibility to dispersed rice starch information for, but not limited to, both research and industrial users.
32544583	0	0	theme	polymeric	79:87	arg1	nanoparticles					89:101	cellulosic biomass and conducting polymeric nanoparticles	45:101	cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal	45:123	Preparation of a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal: Kinetics, isotherms, and energy site distribution.
32544583	5	1	theme	ibuprofen	721:729	arg1	concentration					731:743	initial ibuprofen concentration	713:743	initial ibuprofen concentration	713:743	These parameters were contact time, pH, initial ibuprofen concentration, adsorbent dosage, agitation speed, and temperature and the optimized conditions obtained were 60 min, 5, 30 mg/L, 150 mg, 200 rpm, and 313 K, respectively and ibuprofen removal efficiency reached 88%.
32544583	2	2	dep	cost-effective	473:486	arg1	non-toxic					489:497	non-toxic	489:497	non-toxic	489:497	In this study, cellulosic sisal fibre was modified simultaneously by polypyrrole-polyaniline nanoparticles and it was employed as a cost-effective, non-toxic nano bio-composite for the elimination of ibuprofen.
32544583	4	3	theme	method	665:670	arg1	form					632:635	the form	628:635	the form of the one-factor-at-a-time method	628:670	Parameters were tested in the form of the one-factor-at-a-time method.
32544583	0	4	theme	conducting	68:77	arg1	nanoparticles					89:101	cellulosic biomass and conducting polymeric nanoparticles	45:101	cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal	45:123	Preparation of a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal: Kinetics, isotherms, and energy site distribution.
32544583	4	5	theme	one-factor-at-a-time	644:663	arg1	method					665:670	the one-factor-at-a-time method	640:670	the one-factor-at-a-time method	640:670	Parameters were tested in the form of the one-factor-at-a-time method.
32544583	5	6	theme	contact	695:701	arg1	time					703:706	contact time	695:706	contact time	695:706	These parameters were contact time, pH, initial ibuprofen concentration, adsorbent dosage, agitation speed, and temperature and the optimized conditions obtained were 60 min, 5, 30 mg/L, 150 mg, 200 rpm, and 313 K, respectively and ibuprofen removal efficiency reached 88%.
32544583	8	7	theme	ibuprofen	1555:1563	arg1	removal					1565:1571	ibuprofen removal	1555:1571	ibuprofen removal	1555:1571	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	8	8	theme	more	1260:1263	arg1	sites					1273:1277	more binding sites	1260:1277	more binding sites	1260:1277	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	7	9	theme	R2	1135:1136	arg1	value					1138:1142	the greatest R2 value	1122:1142	the greatest R2 value in the examined temperatures (R2 0.9985 at 298 K)	1122:1192	The Isothermal study demonstrated that Sips assumptions had the greatest R2 value in the examined temperatures (R2 0.9985 at 298 K).
32544583	8	10	theme	higher	1241:1246	arg1	temperature					1248:1258	the higher temperature	1237:1258	the higher temperature	1237:1258	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	2	11	theme	nano	499:502	arg1	it					452:453	it	452:453	it	452:453	In this study, cellulosic sisal fibre was modified simultaneously by polypyrrole-polyaniline nanoparticles and it was employed as a cost-effective, non-toxic nano bio-composite for the elimination of ibuprofen.
32544583	2	11	theme	nano	499:502	arg1	bio-composite					504:516	a cost-effective, non-toxic nano bio-composite	471:516	a cost-effective, non-toxic nano bio-composite for the elimination of ibuprofen	471:549	In this study, cellulosic sisal fibre was modified simultaneously by polypyrrole-polyaniline nanoparticles and it was employed as a cost-effective, non-toxic nano bio-composite for the elimination of ibuprofen.
32544583	8	12	theme	Langmuir	1423:1430	arg1	model					1432:1436	the Langmuir model	1419:1436	the Langmuir model	1419:1436	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	5	13	theme	ibuprofen	905:913	arg1	efficiency					923:932	ibuprofen removal efficiency	905:932	ibuprofen removal efficiency	905:932	These parameters were contact time, pH, initial ibuprofen concentration, adsorbent dosage, agitation speed, and temperature and the optimized conditions obtained were 60 min, 5, 30 mg/L, 150 mg, 200 rpm, and 313 K, respectively and ibuprofen removal efficiency reached 88%.
32544583	0	14	theme	ibuprofen	107:115	arg1	removal					117:123	ibuprofen removal	107:123	ibuprofen removal	107:123	Preparation of a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal: Kinetics, isotherms, and energy site distribution.
32544583	8	15	theme	binding	1265:1271	arg1	sites					1273:1277	more binding sites	1260:1277	more binding sites	1260:1277	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	5	16	theme	removal	915:921	arg1	efficiency					923:932	ibuprofen removal efficiency	905:932	ibuprofen removal efficiency	905:932	These parameters were contact time, pH, initial ibuprofen concentration, adsorbent dosage, agitation speed, and temperature and the optimized conditions obtained were 60 min, 5, 30 mg/L, 150 mg, 200 rpm, and 313 K, respectively and ibuprofen removal efficiency reached 88%.
32544583	5	17	theme	agitation	764:772	arg1	speed					774:778	agitation speed	764:778	agitation speed	764:778	These parameters were contact time, pH, initial ibuprofen concentration, adsorbent dosage, agitation speed, and temperature and the optimized conditions obtained were 60 min, 5, 30 mg/L, 150 mg, 200 rpm, and 313 K, respectively and ibuprofen removal efficiency reached 88%.
32544583	8	18	theme	cellulosic	1458:1467	arg1	adsorbent					1541:1549	adsorbent	1541:1549	adsorbent	1541:1549	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	8	18	theme	cellulosic	1458:1467	arg1	Sisal					1469:1473	313 K. Modified cellulosic Sisal	1442:1473	313 K. Modified cellulosic Sisal	1442:1473	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	7	19	from	298 K	1187:1191	arg1	R2					1174:1175	R2 0.9985	1174:1182	R2 0.9985	1174:1182	The Isothermal study demonstrated that Sips assumptions had the greatest R2 value in the examined temperatures (R2 0.9985 at 298 K).
32544583	7	20	dep	temperatures	1160:1171	arg1	R2					1174:1175	R2 0.9985	1174:1182	R2 0.9985	1174:1182	The Isothermal study demonstrated that Sips assumptions had the greatest R2 value in the examined temperatures (R2 0.9985 at 298 K).
32544583	7	21	theme	Sips	1101:1104	arg1	assumptions					1106:1116	Sips assumptions	1101:1116	Sips assumptions	1101:1116	The Isothermal study demonstrated that Sips assumptions had the greatest R2 value in the examined temperatures (R2 0.9985 at 298 K).
32544583	6	22	theme	Pseudo-second	993:1005	arg1	model					1007:1011	the Pseudo-second model	989:1011	the Pseudo-second model (R2 0.9991)	989:1023	Furthermore, Kinetics data were fitted on the Pseudo-second model (R2 0.9991), indicating a chemisorption process.
32544583	6	22	theme	Pseudo-second	993:1005	arg1	0.9991					1017:1022	R2 0.9991	1014:1022	R2 0.9991	1014:1022	Furthermore, Kinetics data were fitted on the Pseudo-second model (R2 0.9991), indicating a chemisorption process.
32544583	2	23	theme	polypyrrole-polyaniline	410:432	arg1	nanoparticles					434:446	polypyrrole-polyaniline nanoparticles	410:446	polypyrrole-polyaniline nanoparticles	410:446	In this study, cellulosic sisal fibre was modified simultaneously by polypyrrole-polyaniline nanoparticles and it was employed as a cost-effective, non-toxic nano bio-composite for the elimination of ibuprofen.
32544583	8	24	theme	Modified	1449:1456	arg1	adsorbent					1541:1549	adsorbent	1541:1549	adsorbent	1541:1549	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	8	24	theme	Modified	1449:1456	arg1	Sisal					1469:1473	313 K. Modified cellulosic Sisal	1442:1473	313 K. Modified cellulosic Sisal	1442:1473	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	1	25	theme	severe	181:186	arg1	effects					188:194	The severe effects	177:194	The severe effects of pharmaceutical and personal care products (PPCPs)	177:247	The severe effects of pharmaceutical and personal care products (PPCPs) could not be ignored and they must be eliminated prior to their release to the environment.
32544583	0	26	theme	nano	17:20	arg1	bio-composite					22:34	a nano bio-composite	15:34	a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal	15:123	Preparation of a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal: Kinetics, isotherms, and energy site distribution.
32544583	8	27	theme	313 K.	1442:1447	arg1	adsorbent					1541:1549	adsorbent	1541:1549	adsorbent	1541:1549	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	8	27	theme	313 K.	1442:1447	arg1	Sisal					1469:1473	313 K. Modified cellulosic Sisal	1442:1473	313 K. Modified cellulosic Sisal	1442:1473	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	2	28	theme	ibuprofen	541:549	arg1	elimination					526:536	the elimination	522:536	the elimination of ibuprofen	522:549	In this study, cellulosic sisal fibre was modified simultaneously by polypyrrole-polyaniline nanoparticles and it was employed as a cost-effective, non-toxic nano bio-composite for the elimination of ibuprofen.
32544583	8	29	dep	capacity	1386:1393	arg1	concluded					1482:1490	concluded	1482:1490	can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal	1475:1571	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	6	30	theme	R2	1014:1015	arg1	model					1007:1011	the Pseudo-second model	989:1011	the Pseudo-second model (R2 0.9991)	989:1023	Furthermore, Kinetics data were fitted on the Pseudo-second model (R2 0.9991), indicating a chemisorption process.
32544583	6	30	theme	R2	1014:1015	arg1	0.9991					1017:1022	R2 0.9991	1014:1022	R2 0.9991	1014:1022	Furthermore, Kinetics data were fitted on the Pseudo-second model (R2 0.9991), indicating a chemisorption process.
32544583	7	31	theme	Isothermal	1066:1075	arg1	study					1077:1081	The Isothermal study	1062:1081	The Isothermal study	1062:1081	The Isothermal study demonstrated that Sips assumptions had the greatest R2 value in the examined temperatures (R2 0.9985 at 298 K).
32544583	8	32	theme	Energy	1195:1200	arg1	distribution					1207:1218	Energy site distribution	1195:1218	Energy site distribution	1195:1218	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	8	33	theme	cellulosic	1310:1319	arg1	Sisal					1321:1325	the modified cellulosic Sisal	1297:1325	the modified cellulosic Sisal	1297:1325	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	2	34	mod	modified	383:390	arg1	fibre					373:377	fibre	373:377	fibre	373:377	In this study, cellulosic sisal fibre was modified simultaneously by polypyrrole-polyaniline nanoparticles and it was employed as a cost-effective, non-toxic nano bio-composite for the elimination of ibuprofen.
32544583	2	34	mod	modified	383:390	arg3	nanoparticles					434:446	polypyrrole-polyaniline nanoparticles	410:446	polypyrrole-polyaniline nanoparticles	410:446	In this study, cellulosic sisal fibre was modified simultaneously by polypyrrole-polyaniline nanoparticles and it was employed as a cost-effective, non-toxic nano bio-composite for the elimination of ibuprofen.
32544583	1	35	theme	pharmaceutical	199:212	arg1	products					232:239	pharmaceutical and personal care products	199:239	pharmaceutical and personal care products (PPCPs)	199:247	The severe effects of pharmaceutical and personal care products (PPCPs) could not be ignored and they must be eliminated prior to their release to the environment.
32544583	1	35	theme	pharmaceutical	199:212	arg1	PPCPs					242:246	PPCPs	242:246	PPCPs	242:246	The severe effects of pharmaceutical and personal care products (PPCPs) could not be ignored and they must be eliminated prior to their release to the environment.
32544583	0	36	theme	bio-composite	22:34	arg1	Preparation					0:10	Preparation	0:10	Preparation of a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal: Kinetics, isotherms, and energy site distribution.	0:175	Preparation of a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal: Kinetics, isotherms, and energy site distribution.
32544583	5	37	theme	adsorbent	746:754	arg1	dosage					756:761	adsorbent dosage	746:761	adsorbent dosage	746:761	These parameters were contact time, pH, initial ibuprofen concentration, adsorbent dosage, agitation speed, and temperature and the optimized conditions obtained were 60 min, 5, 30 mg/L, 150 mg, 200 rpm, and 313 K, respectively and ibuprofen removal efficiency reached 88%.
32544583	8	38	theme	modified	1301:1308	arg1	Sisal					1321:1325	the modified cellulosic Sisal	1297:1325	the modified cellulosic Sisal	1297:1325	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	5	39	theme	optimized	805:813	arg1	conditions					815:824	the optimized conditions	801:824	the optimized conditions obtained	801:833	These parameters were contact time, pH, initial ibuprofen concentration, adsorbent dosage, agitation speed, and temperature and the optimized conditions obtained were 60 min, 5, 30 mg/L, 150 mg, 200 rpm, and 313 K, respectively and ibuprofen removal efficiency reached 88%.
32544583	5	39	theme	optimized	805:813	arg1	60 min					840:845	60 min	840:845	60 min	840:845	These parameters were contact time, pH, initial ibuprofen concentration, adsorbent dosage, agitation speed, and temperature and the optimized conditions obtained were 60 min, 5, 30 mg/L, 150 mg, 200 rpm, and 313 K, respectively and ibuprofen removal efficiency reached 88%.
32544583	0	40	theme	cellulosic	45:54	arg1	nanoparticles					89:101	cellulosic biomass and conducting polymeric nanoparticles	45:101	cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal	45:123	Preparation of a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal: Kinetics, isotherms, and energy site distribution.
32544583	7	41	theme	greatest	1126:1133	arg1	value					1138:1142	the greatest R2 value	1122:1142	the greatest R2 value in the examined temperatures (R2 0.9985 at 298 K)	1122:1192	The Isothermal study demonstrated that Sips assumptions had the greatest R2 value in the examined temperatures (R2 0.9985 at 298 K).
32544583	0	42	theme	biomass	56:62	arg1	nanoparticles					89:101	cellulosic biomass and conducting polymeric nanoparticles	45:101	cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal	45:123	Preparation of a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal: Kinetics, isotherms, and energy site distribution.
32544583	7	43	contain	had	1118:1120	arg2	value					1138:1142	the greatest R2 value	1122:1142	the greatest R2 value in the examined temperatures (R2 0.9985 at 298 K)	1122:1192	The Isothermal study demonstrated that Sips assumptions had the greatest R2 value in the examined temperatures (R2 0.9985 at 298 K).
32544583	7	43	contain	had	1118:1120	arg1	assumptions					1106:1116	Sips assumptions	1101:1116	Sips assumptions	1101:1116	The Isothermal study demonstrated that Sips assumptions had the greatest R2 value in the examined temperatures (R2 0.9985 at 298 K).
32544583	8	44	theme	site	1202:1205	arg1	distribution					1207:1218	Energy site distribution	1195:1218	Energy site distribution	1195:1218	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	7	45	from	value	1138:1142	arg1	temperatures					1160:1171	the examined temperatures	1147:1171	the examined temperatures (R2 0.9985 at 298 K)	1147:1192	The Isothermal study demonstrated that Sips assumptions had the greatest R2 value in the examined temperatures (R2 0.9985 at 298 K).
32544583	6	46	theme	chemisorption	1039:1051	arg1	process					1053:1059	a chemisorption process	1037:1059	a chemisorption process	1037:1059	Furthermore, Kinetics data were fitted on the Pseudo-second model (R2 0.9991), indicating a chemisorption process.
32544583	8	47	theme	greater	1340:1346	arg1	capacity					1359:1366	greater adsorption capacity	1340:1366	greater adsorption capacity	1340:1366	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	0	48	theme	site	158:161	arg1	distribution					163:174	energy site distribution	151:174	energy site distribution	151:174	Preparation of a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal: Kinetics, isotherms, and energy site distribution.
32544583	8	49	theme	highest	1378:1384	arg1	capacity					1386:1393	the highest capacity	1374:1393	the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal	1374:1571	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	5	50	theme	initial	713:719	arg1	concentration					731:743	initial ibuprofen concentration	713:743	initial ibuprofen concentration	713:743	These parameters were contact time, pH, initial ibuprofen concentration, adsorbent dosage, agitation speed, and temperature and the optimized conditions obtained were 60 min, 5, 30 mg/L, 150 mg, 200 rpm, and 313 K, respectively and ibuprofen removal efficiency reached 88%.
32544583	1	51	theme	personal	218:225	arg1	products					232:239	pharmaceutical and personal care products	199:239	pharmaceutical and personal care products (PPCPs)	199:247	The severe effects of pharmaceutical and personal care products (PPCPs) could not be ignored and they must be eliminated prior to their release to the environment.
32544583	1	51	theme	personal	218:225	arg1	PPCPs					242:246	PPCPs	242:246	PPCPs	242:246	The severe effects of pharmaceutical and personal care products (PPCPs) could not be ignored and they must be eliminated prior to their release to the environment.
32544583	0	52	theme	energy	151:156	arg1	distribution					163:174	energy site distribution	151:174	energy site distribution	151:174	Preparation of a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal: Kinetics, isotherms, and energy site distribution.
32544583	8	53	theme	19.45 mg/g	1398:1407	arg1	capacity					1386:1393	the highest capacity	1374:1393	the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal	1374:1571	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	1	54	theme	care	227:230	arg1	products					232:239	pharmaceutical and personal care products	199:239	pharmaceutical and personal care products (PPCPs)	199:247	The severe effects of pharmaceutical and personal care products (PPCPs) could not be ignored and they must be eliminated prior to their release to the environment.
32544583	1	54	theme	care	227:230	arg1	PPCPs					242:246	PPCPs	242:246	PPCPs	242:246	The severe effects of pharmaceutical and personal care products (PPCPs) could not be ignored and they must be eliminated prior to their release to the environment.
32544583	8	55	theme	adsorption	1348:1357	arg1	capacity					1359:1366	greater adsorption capacity	1340:1366	greater adsorption capacity	1340:1366	Energy site distribution revealed that at the higher temperature more binding sites were activated on the modified cellulosic Sisal, resulted in greater adsorption capacity, with the highest capacity of 19.45 mg/g (based on the Langmuir model) at 313 K. Modified cellulosic Sisal can be concluded to be a cost-effective, prominent, and efficient adsorbent for ibuprofen removal.
32544583	7	56	theme	examined	1151:1158	arg1	temperatures					1160:1171	the examined temperatures	1147:1171	the examined temperatures (R2 0.9985 at 298 K)	1147:1192	The Isothermal study demonstrated that Sips assumptions had the greatest R2 value in the examined temperatures (R2 0.9985 at 298 K).
32544583	1	57	theme	products	232:239	arg1	effects					188:194	The severe effects	177:194	The severe effects of pharmaceutical and personal care products (PPCPs)	177:247	The severe effects of pharmaceutical and personal care products (PPCPs) could not be ignored and they must be eliminated prior to their release to the environment.
32544583	2	58	theme	cost-effective	473:486	arg1	it					452:453	it	452:453	it	452:453	In this study, cellulosic sisal fibre was modified simultaneously by polypyrrole-polyaniline nanoparticles and it was employed as a cost-effective, non-toxic nano bio-composite for the elimination of ibuprofen.
32544583	2	58	theme	cost-effective	473:486	arg1	bio-composite					504:516	a cost-effective, non-toxic nano bio-composite	471:516	a cost-effective, non-toxic nano bio-composite for the elimination of ibuprofen	471:549	In this study, cellulosic sisal fibre was modified simultaneously by polypyrrole-polyaniline nanoparticles and it was employed as a cost-effective, non-toxic nano bio-composite for the elimination of ibuprofen.
32544583	0	59	dep	Preparation	0:10	arg1	distribution					163:174	energy site distribution	151:174	energy site distribution	151:174	Preparation of a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal: Kinetics, isotherms, and energy site distribution.
32544583	0	59	dep	Preparation	0:10	arg1	isotherms					136:144	isotherms	136:144	isotherms	136:144	Preparation of a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal: Kinetics, isotherms, and energy site distribution.
32544583	0	59	dep	Preparation	0:10	arg1	Kinetics					126:133	Kinetics	126:133	Kinetics	126:133	Preparation of a nano bio-composite based on cellulosic biomass and conducting polymeric nanoparticles for ibuprofen removal: Kinetics, isotherms, and energy site distribution.
32544583	6	60	theme	Kinetics	960:967	arg1	data					969:972	Kinetics data	960:972	Kinetics data	960:972	Furthermore, Kinetics data were fitted on the Pseudo-second model (R2 0.9991), indicating a chemisorption process.
33342323	5	0	theme	nanostructure	1194:1206	arg1	profile					1173:1179	The drug release profile	1156:1179	The drug release profile of developed nanostructure with ultrasound-activation	1156:1233	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	4	1	theme	loaded	1113:1118	arg1	structures					1144:1153	RV loaded spherical morphological structures	1110:1153	RV loaded spherical morphological structures	1110:1153	The structural and morphology analyses result established that prepared nano-formulations have successful molecular interactions and RV loaded spherical morphological structures.
33342323	3	2	theme	silica	691:696	arg1	nanoparticles					698:710	encapsulated mesoporous silica nanoparticles	667:710	encapsulated mesoporous silica nanoparticles	667:710	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	7	3	dep	demonstrated	1661:1672	arg1	treated					1674:1680	treated	1674:1680	demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology	1661:1776	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	6	4	theme	other	1526:1530	arg1	samples					1532:1538	other samples	1526:1538	other samples due to its porous surface and suitable biopolymer proportions	1526:1600	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	4	5	theme	morphological	1130:1142	arg1	structures					1144:1153	RV loaded spherical morphological structures	1110:1153	RV loaded spherical morphological structures	1110:1153	The structural and morphology analyses result established that prepared nano-formulations have successful molecular interactions and RV loaded spherical morphological structures.
33342323	3	6	gly	glycosylated	639:650	arg1	chitosan					652:659	glycosylated chitosan	639:659	glycosylated chitosan (GCS)	639:665	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	3	6	gly	glycosylated	639:650	arg1	GCS					662:664	GCS	662:664	GCS	662:664	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	5	7	from	2 h	1276:1278	arg1	%					1255:1255	50%	1253:1255	50% of drug release in 2 h	1253:1278	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	5	7	from	2 h	1276:1278	arg1	%					1286:1286	90%	1284:1286	90% of drug release	1284:1302	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	5	7	from	2 h	1276:1278	arg1	release					1296:1302	drug release	1291:1302	drug release	1291:1302	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	5	7	from	2 h	1276:1278	arg1	release					1265:1271	drug release	1260:1271	drug release in 2 h	1260:1278	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	8	8	theme	MONPs	1794:1798	arg1	formulations					1806:1817	MONPs based formulations	1794:1817	MONPs based formulations	1794:1817	This developed MONPs based formulations with ultrasound-irradiation gives a prospective technique to clinical agony the board through on-request and dependable help with discomfort.
33342323	1	9	theme	anesthetic	193:202	arg1	system					209:214	local anesthetic (LA) system	187:214	local anesthetic (LA) system	187:214	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	5	10	from	release	1265:1271	arg1	2 h					1276:1278	2 h	1276:1278	2 h	1276:1278	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	1	11	theme	LA	205:206	arg1	system					209:214	local anesthetic (LA) system	187:214	local anesthetic (LA) system	187:214	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	7	12	theme	GCS-MONPs	1725:1733	arg1	RV					1735:1736	GCS-MONPs@RV	1725:1736	GCS-MONPs@RV	1725:1736	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	8	13	dep	on-request	1913:1922	arg1	help					1939:1942	help	1939:1942	help with discomfort	1939:1958	This developed MONPs based formulations with ultrasound-irradiation gives a prospective technique to clinical agony the board through on-request and dependable help with discomfort.
33342323	3	14	theme	sustainable	748:758	arg1	distributions					760:772	sustainable distributions	748:772	sustainable distributions	748:772	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	1	15	theme	peripheral	404:413	arg1	nerves					415:420	human peripheral nerves	398:420	human peripheral nerves	398:420	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	6	16	theme	suitable	1570:1577	arg1	proportions					1590:1600	suitable biopolymer proportions	1570:1600	suitable biopolymer proportions	1570:1600	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	3	17	dep	design	613:618	arg1	nanoparticles					698:710	encapsulated mesoporous silica nanoparticles	667:710	encapsulated mesoporous silica nanoparticles	667:710	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	2	18	theme	post-operative	542:555	arg1	management					562:571	the post-operative pain management	538:571	the post-operative pain management	538:571	Ropivacaine (RV) is one of the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management.
33342323	3	19	theme	stacked	810:816	arg1	RV					818:819	stacked RV	810:819	stacked RV	810:819	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	0	20	theme	in vivo	144:150	arg1	investigations					152:165	in vivo investigations	144:165	in vivo investigations	144:165	Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: in vitro and in vivo investigations.
33342323	5	21	theme	drug	1160:1163	arg1	profile					1173:1179	The drug release profile	1156:1179	The drug release profile of developed nanostructure with ultrasound-activation	1156:1233	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	3	22	dep	payload	920:926	arg1	discharge					906:914	discharge	906:914	discharge	906:914	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	7	23	dep	ex	1619:1620	arg1	vitro					1622:1626	vitro	1622:1626	vitro	1622:1626	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	3	24	theme	outer	875:879	arg1	ultrasound					881:890	either outer ultrasound	868:890	either outer ultrasound	868:890	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	7	25	theme	animal	1682:1687	arg1	models					1689:1694	animal models	1682:1694	animal models	1682:1694	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	8	26	theme	clinical	1880:1887	arg1	agony					1889:1893	clinical agony	1880:1893	clinical agony	1880:1893	This developed MONPs based formulations with ultrasound-irradiation gives a prospective technique to clinical agony the board through on-request and dependable help with discomfort.
33342323	1	27	theme	transmission	339:350	arg1	mechanism					319:327	the reversible obstructive mechanism	292:327	the reversible obstructive mechanism of neural transmission	292:350	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	0	28	theme	local	15:19	arg1	system					46:51	local anesthetic drug delivery system	15:51	local anesthetic drug delivery system by administration of organo-silica	15:86	Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: in vitro and in vivo investigations.
33342323	2	29	with	s	482:482	arg1	actions					493:499	the actions	489:499	the actions of long-lasting and low-toxicity for the post-operative pain management	489:571	Ropivacaine (RV) is one of the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management.
33342323	7	30	theme	relief	1645:1650	arg1	analysis					1652:1659	ex vitro and in vivo pain relief analysis	1619:1659	ex vitro and in vivo pain relief analysis	1619:1659	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	0	31	theme	organo-silica	74:86	arg1	administration					56:69	administration	56:69	administration of organo-silica	56:86	Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: in vitro and in vivo investigations.
33342323	7	32	theme	in vivo	1632:1638	arg1	analysis					1652:1659	ex vitro and in vivo pain relief analysis	1619:1659	ex vitro and in vivo pain relief analysis	1619:1659	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	6	33	theme	compatibility	1418:1430	arg1	analysis					1432:1439	The in vitro cell compatibility analysis	1400:1439	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV	1400:1467	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	1	34	theme	innervation	375:385	arg1	process					387:393	the innervation process	371:393	the innervation process in human peripheral nerves	371:420	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	0	35	dep	stimuli	122:128	arg1	in vitro					131:138	in vitro	131:138	in vitro	131:138	Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: in vitro and in vivo investigations.
33342323	0	35	dep	stimuli	122:128	arg1	investigations					152:165	in vivo investigations	144:165	in vivo investigations	144:165	Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: in vitro and in vivo investigations.
33342323	3	36	theme	foundation	929:938	arg1	on-request					940:949	foundation on-request	929:949	foundation on-request	929:949	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	5	37	with	profile	1173:1179	arg1	ultrasound-activation					1213:1233	ultrasound-activation	1213:1233	ultrasound-activation	1213:1233	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	6	38	theme	in vitro	1404:1411	arg1	analysis					1432:1439	The in vitro cell compatibility analysis	1400:1439	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV	1400:1467	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	5	39	theme	developed	1184:1192	arg1	nanostructure					1194:1206	developed nanostructure	1184:1206	developed nanostructure	1184:1206	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	0	40	theme	delivery	37:44	arg1	system					46:51	local anesthetic drug delivery system	15:51	local anesthetic drug delivery system by administration of organo-silica	15:86	Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: in vitro and in vivo investigations.
33342323	2	41	theme	greatest	454:461	arg1	s					482:482	the greatest frequently used LA s	450:482	the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management	450:571	Ropivacaine (RV) is one of the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management.
33342323	5	42	theme	drug	1260:1263	arg1	release					1265:1271	drug release	1260:1271	drug release in 2 h	1260:1278	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	6	43	theme	survival	1494:1501	arg1	rates					1503:1507	improved neuron cell survival rates	1473:1507	improved neuron cell survival rates	1473:1507	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	7	44	theme	@	1734:1734	arg1	RV					1735:1736	GCS-MONPs@RV	1725:1736	GCS-MONPs@RV	1725:1736	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	1	45	from	process	387:393	arg1	nerves					415:420	human peripheral nerves	398:420	human peripheral nerves	398:420	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	2	46	theme	s	482:482	arg1	one					443:445	one	443:445	one	443:445	Ropivacaine (RV) is one of the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management.
33342323	2	46	theme	s	482:482	arg1	s					482:482	the greatest frequently used LA s	450:482	the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management	450:571	Ropivacaine (RV) is one of the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management.
33342323	5	47	theme	free	1382:1385	arg1	solution					1390:1397	free RV solution	1382:1397	free RV solution	1382:1397	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	6	48	theme	neuron	1482:1487	arg1	survival					1494:1501	improved neuron cell survival	1473:1501	improved neuron cell survival rates	1473:1507	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	1	49	theme	obstructive	307:317	arg1	mechanism					319:327	the reversible obstructive mechanism	292:327	the reversible obstructive mechanism of neural transmission	292:350	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	0	50	theme	drug	32:35	arg1	system					46:51	local anesthetic drug delivery system	15:51	local anesthetic drug delivery system by administration of organo-silica	15:86	Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: in vitro and in vivo investigations.
33342323	4	51	theme	successful	1072:1081	arg1	interactions					1093:1104	successful molecular interactions	1072:1104	successful molecular interactions	1072:1104	The structural and morphology analyses result established that prepared nano-formulations have successful molecular interactions and RV loaded spherical morphological structures.
33342323	3	52	theme	glycosylated	639:650	arg1	chitosan					652:659	glycosylated chitosan	639:659	glycosylated chitosan (GCS)	639:665	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	3	52	theme	glycosylated	639:650	arg1	GCS					662:664	GCS	662:664	GCS	662:664	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	0	53	theme	system	46:51	arg1	Development					0:10	Development	0:10	Development of local anesthetic drug delivery system by administration of organo-silica	0:86	Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: in vitro and in vivo investigations.
33342323	3	54	theme	mesoporous	680:689	arg1	nanoparticles					698:710	encapsulated mesoporous silica nanoparticles	667:710	encapsulated mesoporous silica nanoparticles	667:710	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	6	55	theme	porous	1551:1556	arg1	surface					1558:1564	its porous surface	1547:1564	its porous surface	1547:1564	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	5	56	theme	drug	1291:1294	arg1	release					1296:1302	drug release	1291:1302	drug release	1291:1302	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	6	57	contain	has	1469:1471	arg2	rates					1503:1507	improved neuron cell survival rates	1473:1507	improved neuron cell survival rates	1473:1507	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	6	57	contain	has	1469:1471	arg1	analysis					1432:1439	The in vitro cell compatibility analysis	1400:1439	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV	1400:1467	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	1	58	theme	commercial	238:247	arg1	drug					249:252	commercial drug	238:252	commercial drug	238:252	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	4	59	theme	spherical	1120:1128	arg1	structures					1144:1153	RV loaded spherical morphological structures	1110:1153	RV loaded spherical morphological structures	1110:1153	The structural and morphology analyses result established that prepared nano-formulations have successful molecular interactions and RV loaded spherical morphological structures.
33342323	5	60	from	%	1255:1255	arg1	2 h					1276:1278	2 h	1276:1278	2 h	1276:1278	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	4	61	contain	have	1067:1070	arg2	interactions					1093:1104	successful molecular interactions	1072:1104	successful molecular interactions	1072:1104	The structural and morphology analyses result established that prepared nano-formulations have successful molecular interactions and RV loaded spherical morphological structures.
33342323	4	61	contain	have	1067:1070	arg2	structures					1144:1153	RV loaded spherical morphological structures	1110:1153	RV loaded spherical morphological structures	1110:1153	The structural and morphology analyses result established that prepared nano-formulations have successful molecular interactions and RV loaded spherical morphological structures.
33342323	4	61	contain	have	1067:1070	arg1	nano-formulations					1049:1065	prepared nano-formulations	1040:1065	prepared nano-formulations	1040:1065	The structural and morphology analyses result established that prepared nano-formulations have successful molecular interactions and RV loaded spherical morphological structures.
33342323	1	62	theme	pain	262:265	arg1	management					267:276	the pain management	258:276	the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves	258:420	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	4	63	theme	prepared	1040:1047	arg1	nano-formulations					1049:1065	prepared nano-formulations	1040:1065	prepared nano-formulations	1040:1065	The structural and morphology analyses result established that prepared nano-formulations have successful molecular interactions and RV loaded spherical morphological structures.
33342323	1	64	theme	local	187:191	arg1	system					209:214	local anesthetic (LA) system	187:214	local anesthetic (LA) system	187:214	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	3	65	theme	-based	723:728	arg1	nano-scaffold					730:742	novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold	607:742	novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia	607:974	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	3	66	theme	controlled/supported	778:797	arg1	arrival					799:805	controlled/supported arrival	778:805	controlled/supported arrival	778:805	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	5	67	from	%	1286:1286	arg1	2 h					1276:1278	2 h	1276:1278	2 h	1276:1278	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	6	68	theme	biopolymer	1579:1588	arg1	proportions					1590:1600	suitable biopolymer proportions	1570:1600	suitable biopolymer proportions	1570:1600	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	7	69	theme	high	1701:1704	arg1	compatibility					1706:1718	high compatibility	1701:1718	high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology	1701:1776	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	2	70	theme	pain	557:560	arg1	management					562:571	the post-operative pain management	538:571	the post-operative pain management	538:571	Ropivacaine (RV) is one of the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management.
33342323	4	71	dep	structural	981:990	arg1	analyses					1007:1014	analyses	1007:1014	analyses	1007:1014	The structural and morphology analyses result established that prepared nano-formulations have successful molecular interactions and RV loaded spherical morphological structures.
33342323	3	72	theme	RV	818:819	arg1	distributions					760:772	sustainable distributions	748:772	sustainable distributions	748:772	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	3	72	theme	RV	818:819	arg1	arrival					799:805	controlled/supported arrival	778:805	controlled/supported arrival	778:805	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	5	73	theme	release	1165:1171	arg1	profile					1173:1179	The drug release profile	1156:1179	The drug release profile of developed nanostructure with ultrasound-activation	1156:1233	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	4	74	dep	result	1016:1021	arg1	established					1023:1033	established	1023:1033	result established that prepared nano-formulations have successful molecular interactions and RV loaded spherical morphological structures	1016:1153	The structural and morphology analyses result established that prepared nano-formulations have successful molecular interactions and RV loaded spherical morphological structures.
33342323	8	75	theme	prospective	1855:1865	arg1	technique					1867:1875	a prospective technique	1853:1875	a prospective technique to clinical agony	1853:1893	This developed MONPs based formulations with ultrasound-irradiation gives a prospective technique to clinical agony the board through on-request and dependable help with discomfort.
33342323	7	76	theme	analysis	1652:1659	arg1	analysis					1607:1614	The analysis	1603:1614	The analysis of ex vitro and in vivo pain relief analysis	1603:1659	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	8	77	theme	based	1800:1804	arg1	formulations					1806:1817	MONPs based formulations	1794:1817	MONPs based formulations	1794:1817	This developed MONPs based formulations with ultrasound-irradiation gives a prospective technique to clinical agony the board through on-request and dependable help with discomfort.
33342323	5	78	theme	controlled	1346:1355	arg1	release					1357:1363	more controlled release	1341:1363	more controlled release	1341:1363	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	3	79	theme	novel	607:611	arg1	design					613:618	novel design	607:618	novel design	607:618	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	7	80	theme	pain	1640:1643	arg1	relief					1645:1650	pain relief	1640:1650	ex vitro and in vivo pain relief analysis	1619:1659	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	0	81	theme	ultrasound	111:120	arg1	stimuli					122:128	ultrasound stimuli	111:128	ultrasound stimuli: in vitro and in vivo investigations	111:165	Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: in vitro and in vivo investigations.
33342323	7	82	theme	ex	1619:1620	arg1	analysis					1652:1659	ex vitro and in vivo pain relief analysis	1619:1659	ex vitro and in vivo pain relief analysis	1619:1659	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	2	83	theme	low-toxicity	521:532	arg1	actions					493:499	the actions	489:499	the actions of long-lasting and low-toxicity for the post-operative pain management	489:571	Ropivacaine (RV) is one of the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management.
33342323	5	84	theme	RV	1387:1388	arg1	solution					1390:1397	free RV solution	1382:1397	free RV solution	1382:1397	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	6	85	theme	cell	1413:1416	arg1	analysis					1432:1439	The in vitro cell compatibility analysis	1400:1439	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV	1400:1467	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	1	86	theme	system	209:214	arg1	application					223:233	the application	219:233	the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves	219:420	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	1	86	theme	system	209:214	arg1	development					172:182	The development	168:182	The development of local anesthetic (LA) system	168:214	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	7	87	contain	have	1696:1699	arg1	models					1689:1694	animal models	1682:1694	animal models	1682:1694	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	7	87	contain	have	1696:1699	arg2	compatibility					1706:1718	high compatibility	1701:1718	high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology	1701:1776	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	2	88	theme	long-lasting	504:515	arg1	actions					493:499	the actions	489:499	the actions of long-lasting and low-toxicity for the post-operative pain management	489:571	Ropivacaine (RV) is one of the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management.
33342323	1	89	theme	human	398:402	arg1	nerves					415:420	human peripheral nerves	398:420	human peripheral nerves	398:420	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	2	90	dep	greatest	454:461	arg1	used					474:477	used	474:477	used	474:477	Ropivacaine (RV) is one of the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management.
33342323	7	91	with	compatibility	1706:1718	arg1	RV					1735:1736	GCS-MONPs@RV	1725:1736	GCS-MONPs@RV	1725:1736	The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology.
33342323	4	92	theme	molecular	1083:1091	arg1	interactions					1093:1104	successful molecular interactions	1072:1104	successful molecular interactions	1072:1104	The structural and morphology analyses result established that prepared nano-formulations have successful molecular interactions and RV loaded spherical morphological structures.
33342323	0	93	theme	anesthetic	21:30	arg1	system					46:51	local anesthetic drug delivery system	15:51	local anesthetic drug delivery system by administration of organo-silica	15:86	Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli: in vitro and in vivo investigations.
33342323	5	94	theme	release	1265:1271	arg1	%					1255:1255	50%	1253:1255	50% of drug release in 2 h	1253:1278	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	5	94	theme	release	1265:1271	arg1	%					1286:1286	90%	1284:1286	90% of drug release	1284:1302	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	5	94	theme	release	1265:1271	arg1	release					1296:1302	drug release	1291:1302	drug release	1291:1302	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	5	94	theme	release	1265:1271	arg1	release					1265:1271	drug release	1260:1271	drug release in 2 h	1260:1278	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	3	95	theme	chitosan	652:659	arg1	design					613:618	novel design	607:618	novel design	607:618	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	3	95	theme	chitosan	652:659	arg1	development					624:634	development	624:634	development of glycosylated chitosan (GCS)	624:665	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	6	96	theme	cell	1489:1492	arg1	survival					1494:1501	improved neuron cell survival	1473:1501	improved neuron cell survival rates	1473:1507	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	1	97	theme	reversible	296:305	arg1	mechanism					319:327	the reversible obstructive mechanism	292:327	the reversible obstructive mechanism of neural transmission	292:350	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	3	98	theme	dependable	955:964	arg1	analgesia					966:974	dependable analgesia	955:974	dependable analgesia	955:974	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	2	99	theme	LA	479:480	arg1	s					482:482	the greatest frequently used LA s	450:482	the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management	450:571	Ropivacaine (RV) is one of the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management.
33342323	6	100	theme	improved	1473:1480	arg1	survival					1494:1501	improved neuron cell survival	1473:1501	improved neuron cell survival rates	1473:1507	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	3	101	dep	-based	723:728	arg1	design					613:618	novel design	607:618	novel design	607:618	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	3	101	dep	-based	723:728	arg1	development					624:634	development	624:634	development of glycosylated chitosan (GCS)	624:665	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	3	102	theme	encapsulated	667:678	arg1	nanoparticles					698:710	encapsulated mesoporous silica nanoparticles	667:710	encapsulated mesoporous silica nanoparticles	667:710	In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia.
33342323	1	103	theme	neural	332:337	arg1	transmission					339:350	neural transmission	332:350	neural transmission	332:350	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	6	104	with	GCS-MONPs	1451:1459	arg1	RV					1466:1467	RV	1466:1467	RV	1466:1467	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	5	105	theme	release	1296:1302	arg1	%					1255:1255	50%	1253:1255	50% of drug release in 2 h	1253:1278	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	5	105	theme	release	1296:1302	arg1	%					1286:1286	90%	1284:1286	90% of drug release	1284:1302	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	5	105	theme	release	1296:1302	arg1	release					1296:1302	drug release	1291:1302	drug release	1291:1302	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	5	105	theme	release	1296:1302	arg1	release					1265:1271	drug release	1260:1271	drug release in 2 h	1260:1278	The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution.
33342323	6	106	theme	due	1540:1542	arg1	samples					1532:1538	other samples	1526:1538	other samples due to its porous surface and suitable biopolymer proportions	1526:1600	The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions.
33342323	1	107	theme	drug	249:252	arg1	application					223:233	the application	219:233	the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves	219:420	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
33342323	1	107	theme	drug	249:252	arg1	development					172:182	The development	168:182	The development of local anesthetic (LA) system	168:214	The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves.
32600714	10	0	theme	regeneration	1704:1715	arg1	applications					1717:1728	cartilage regeneration applications	1694:1728	cartilage regeneration applications	1694:1728	Overall results demonstrated that the developed GG/LGNF/FS-MEL hydrogels can be offered as promising materials for cartilage regeneration applications.
32600714	3	1	theme	1-5 w/v	765:771	arg1	%					772:772	%	772:772	%	772:772	Gelation time and temperature were determined for different hydrogel formulation containing 1-5 w/v% LGNF and 0.1-0.3 w/v% FS-MEL.
32600714	7	2	from	study	1198:1202	arg1	PBS					1207:1209	PBS	1207:1209	PBS	1207:1209	The results of MEL release study in PBS revealed that MEL showed more sustained release from the hydrogel compared to FS nanoparticles.
32600714	5	3	theme	Degradation	884:894	arg1	rate					896:899	Degradation rate	884:899	Degradation rate	884:899	Degradation rate and swelling degree of developed hydrogel were evaluated to determine the effect of LGNF and FS on hydrogel behaviour.
32600714	2	4	theme	injectable	421:430	arg1	hydrogel					432:439	a novel injectable hydrogel	413:439	a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL)	413:584	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	7	5	dep	showed	1229:1234	arg1	compared					1277:1284	compared	1277:1284	showed more sustained release from the hydrogel compared to FS nanoparticles	1229:1304	The results of MEL release study in PBS revealed that MEL showed more sustained release from the hydrogel compared to FS nanoparticles.
32600714	1	6	theme	tissue	310:315	arg1	engineering					317:327	cartilage tissue engineering	300:327	cartilage tissue engineering	300:327	Injectable hydrogels based on natural polysaccharides have attracted considerable attention in cartilage tissue engineering, especially those reinforced with mineral nanofilers carrying drug molecules.
32600714	1	6	theme	tissue	310:315	arg1	those					341:345	those	341:345	those	341:345	Injectable hydrogels based on natural polysaccharides have attracted considerable attention in cartilage tissue engineering, especially those reinforced with mineral nanofilers carrying drug molecules.
32600714	6	7	theme	hydrogels	1114:1122	arg1	strength					1099:1106	strength	1099:1106	strength of GG hydrogels	1099:1122	Results of mechanical characterization showed that the compressive modulus and strength of GG hydrogels were improved by incorporation of LGNF and FS.
32600714	6	7	theme	hydrogels	1114:1122	arg1	modulus					1087:1093	the compressive modulus	1071:1093	the compressive modulus	1071:1093	Results of mechanical characterization showed that the compressive modulus and strength of GG hydrogels were improved by incorporation of LGNF and FS.
32600714	3	8	theme	hydrogel	733:740	arg1	formulation					742:752	different hydrogel formulation	723:752	different hydrogel formulation containing 1-5 w/v% LGNF and 0.1-0.3 w/v% FS-MEL	723:801	Gelation time and temperature were determined for different hydrogel formulation containing 1-5 w/v% LGNF and 0.1-0.3 w/v% FS-MEL.
32600714	2	9	theme	biological	633:642	arg1	properties					644:653	enhanced mechanical and biological properties	609:653	properties	644:653	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	2	10	theme	novel	415:419	arg1	hydrogel					432:439	a novel injectable hydrogel	413:439	a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL)	413:584	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	0	11	theme	tissue	129:134	arg1	engineering					136:146	cartilage tissue engineering	119:146	cartilage tissue engineering	119:146	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies.
32600714	5	12	theme	hydrogel	1000:1007	arg1	behaviour					1009:1017	hydrogel behaviour	1000:1017	hydrogel behaviour	1000:1017	Degradation rate and swelling degree of developed hydrogel were evaluated to determine the effect of LGNF and FS on hydrogel behaviour.
32600714	6	13	theme	characterization	1042:1057	arg1	Results					1020:1026	Results	1020:1026	Results of mechanical characterization	1020:1057	Results of mechanical characterization showed that the compressive modulus and strength of GG hydrogels were improved by incorporation of LGNF and FS.
32600714	0	14	theme	cartilage	119:127	arg1	engineering					136:146	cartilage tissue engineering	119:146	cartilage tissue engineering	119:146	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies.
32600714	7	15	from	PBS	1207:1209	arg1	results					1175:1181	The results	1171:1181	The results of MEL release study in PBS	1171:1209	The results of MEL release study in PBS revealed that MEL showed more sustained release from the hydrogel compared to FS nanoparticles.
32600714	7	16	theme	FS	1289:1290	arg1	nanoparticles					1292:1304	FS nanoparticles	1289:1304	FS nanoparticles	1289:1304	The results of MEL release study in PBS revealed that MEL showed more sustained release from the hydrogel compared to FS nanoparticles.
32600714	4	17	theme	injectability	808:820	arg1	test					822:825	The injectability test	804:825	The injectability test	804:825	The injectability test proved the ease of injection of the developed hydrogels.
32600714	9	18	theme	gene	1438:1441	arg1	expression					1443:1452	gene expression	1438:1452	gene expression	1438:1452	Results exhibited higher cell adhesion, proliferation and gene expression on GG/LGNF/FS-MEL hydrogel compared to GG/LGNF and GG/LGNF/FS, which can be attributed to the synergic effect of FS and MEL.
32600714	6	19	theme	mechanical	1031:1040	arg1	characterization					1042:1057	mechanical characterization	1031:1057	mechanical characterization	1031:1057	Results of mechanical characterization showed that the compressive modulus and strength of GG hydrogels were improved by incorporation of LGNF and FS.
32600714	2	20	theme	FS	559:560	arg1	FS-MEL					578:583	FS-MEL	578:583	FS-MEL	578:583	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	2	20	theme	FS	559:560	arg1	nanoparticles					563:575	melatonin (MEL) loaded forsterite (FS) nanoparticles	524:575	melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL)	524:584	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	3	21	theme	0.1-0.3 w/v	783:793	arg1	%					794:794	%	794:794	%	794:794	Gelation time and temperature were determined for different hydrogel formulation containing 1-5 w/v% LGNF and 0.1-0.3 w/v% FS-MEL.
32600714	6	22	theme	LGNF	1158:1161	arg1	incorporation					1141:1153	incorporation	1141:1153	incorporation of LGNF and FS	1141:1168	Results of mechanical characterization showed that the compressive modulus and strength of GG hydrogels were improved by incorporation of LGNF and FS.
32600714	6	23	theme	GG	1111:1112	arg1	hydrogels					1114:1122	GG hydrogels	1111:1122	GG hydrogels	1111:1122	Results of mechanical characterization showed that the compressive modulus and strength of GG hydrogels were improved by incorporation of LGNF and FS.
32600714	5	24	theme	developed	924:932	arg1	hydrogel					934:941	developed hydrogel	924:941	developed hydrogel	924:941	Degradation rate and swelling degree of developed hydrogel were evaluated to determine the effect of LGNF and FS on hydrogel behaviour.
32600714	1	25	theme	Injectable	205:214	arg1	hydrogels					216:224	Injectable hydrogels	205:224	Injectable hydrogels based on natural polysaccharides	205:257	Injectable hydrogels based on natural polysaccharides have attracted considerable attention in cartilage tissue engineering, especially those reinforced with mineral nanofilers carrying drug molecules.
32600714	10	26	theme	cartilage	1694:1702	arg1	applications					1717:1728	cartilage regeneration applications	1694:1728	cartilage regeneration applications	1694:1728	Overall results demonstrated that the developed GG/LGNF/FS-MEL hydrogels can be offered as promising materials for cartilage regeneration applications.
32600714	3	27	theme	%	772:772	arg1	LGNF					774:777	1-5 w/v% LGNF	765:777	1-5 w/v% LGNF	765:777	Gelation time and temperature were determined for different hydrogel formulation containing 1-5 w/v% LGNF and 0.1-0.3 w/v% FS-MEL.
32600714	2	28	theme	hydrogels	662:670	arg1	mechanical					618:627	mechanical	618:627	mechanical	618:627	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	2	29	theme	gum	457:459	arg1	composite					500:508	gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite	450:508	gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL)	450:584	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	0	30	theme	gellan	11:16	arg1	hydrogels					49:57	Injectable gellan gum/lignocellulose nanofibrils hydrogels	0:57	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded	0:88	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies.
32600714	9	31	theme	higher	1398:1403	arg1	adhesion					1410:1417	higher cell adhesion	1398:1417	higher cell adhesion	1398:1417	Results exhibited higher cell adhesion, proliferation and gene expression on GG/LGNF/FS-MEL hydrogel compared to GG/LGNF and GG/LGNF/FS, which can be attributed to the synergic effect of FS and MEL.
32600714	10	32	theme	GG/LGNF/FS-MEL	1627:1640	arg1	materials					1680:1688	promising materials	1670:1688	promising materials for cartilage regeneration applications	1670:1728	Overall results demonstrated that the developed GG/LGNF/FS-MEL hydrogels can be offered as promising materials for cartilage regeneration applications.
32600714	10	32	theme	GG/LGNF/FS-MEL	1627:1640	arg1	hydrogels					1642:1650	the developed GG/LGNF/FS-MEL hydrogels	1613:1650	the developed GG/LGNF/FS-MEL hydrogels	1613:1650	Overall results demonstrated that the developed GG/LGNF/FS-MEL hydrogels can be offered as promising materials for cartilage regeneration applications.
32600714	10	33	theme	promising	1670:1678	arg1	materials					1680:1688	promising materials	1670:1688	promising materials for cartilage regeneration applications	1670:1728	Overall results demonstrated that the developed GG/LGNF/FS-MEL hydrogels can be offered as promising materials for cartilage regeneration applications.
32600714	10	33	theme	promising	1670:1678	arg1	hydrogels					1642:1650	the developed GG/LGNF/FS-MEL hydrogels	1613:1650	the developed GG/LGNF/FS-MEL hydrogels	1613:1650	Overall results demonstrated that the developed GG/LGNF/FS-MEL hydrogels can be offered as promising materials for cartilage regeneration applications.
32600714	2	34	theme	gellan	450:455	arg1	gum					457:459	gellan gum	450:459	gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL)	450:584	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	2	34	theme	gellan	450:455	arg1	GG					462:463	GG	462:463	GG	462:463	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	0	35	theme	Injectable	0:9	arg1	hydrogels					49:57	Injectable gellan gum/lignocellulose nanofibrils hydrogels	0:57	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded	0:88	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies.
32600714	9	36	theme	cell	1405:1408	arg1	adhesion					1410:1417	higher cell adhesion	1398:1417	higher cell adhesion	1398:1417	Results exhibited higher cell adhesion, proliferation and gene expression on GG/LGNF/FS-MEL hydrogel compared to GG/LGNF and GG/LGNF/FS, which can be attributed to the synergic effect of FS and MEL.
32600714	0	37	dep	nanoparticles	101:113	arg1	characterization					162:177	characterization	162:177	characterization	162:177	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies.
32600714	0	37	dep	nanoparticles	101:113	arg1	nanoparticles					101:113	nanoparticles	101:113	nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies	101:202	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies.
32600714	0	37	dep	nanoparticles	101:113	arg1	Fabrication					149:159	Fabrication	149:159	Fabrication	149:159	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies.
32600714	0	37	dep	nanoparticles	101:113	arg1	studies					196:202	cell culture studies	183:202	cell culture studies	183:202	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies.
32600714	8	38	theme	Cell-hydrogels	1307:1320	arg1	interaction					1322:1332	Cell-hydrogels interaction	1307:1332	Cell-hydrogels interaction	1307:1332	Cell-hydrogels interaction was evaluated by culturing chondrocyte cells.
32600714	5	39	theme	hydrogel	934:941	arg1	rate					896:899	Degradation rate	884:899	Degradation rate	884:899	Degradation rate and swelling degree of developed hydrogel were evaluated to determine the effect of LGNF and FS on hydrogel behaviour.
32600714	5	39	theme	hydrogel	934:941	arg1	degree					914:919	swelling degree	905:919	swelling degree	905:919	Degradation rate and swelling degree of developed hydrogel were evaluated to determine the effect of LGNF and FS on hydrogel behaviour.
32600714	0	40	theme	nanofibrils	37:47	arg1	hydrogels					49:57	Injectable gellan gum/lignocellulose nanofibrils hydrogels	0:57	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded	0:88	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies.
32600714	8	41	theme	chondrocyte	1361:1371	arg1	cells					1373:1377	chondrocyte cells	1361:1377	chondrocyte cells	1361:1377	Cell-hydrogels interaction was evaluated by culturing chondrocyte cells.
32600714	5	42	from	effect	975:980	arg1	behaviour					1009:1017	hydrogel behaviour	1000:1017	hydrogel behaviour	1000:1017	Degradation rate and swelling degree of developed hydrogel were evaluated to determine the effect of LGNF and FS on hydrogel behaviour.
32600714	1	43	contain	carrying	382:389	arg2	molecules					396:404	drug molecules	391:404	drug molecules	391:404	Injectable hydrogels based on natural polysaccharides have attracted considerable attention in cartilage tissue engineering, especially those reinforced with mineral nanofilers carrying drug molecules.
32600714	1	43	contain	carrying	382:389	arg1	nanofilers					371:380	mineral nanofilers	363:380	mineral nanofilers carrying drug molecules	363:404	Injectable hydrogels based on natural polysaccharides have attracted considerable attention in cartilage tissue engineering, especially those reinforced with mineral nanofilers carrying drug molecules.
32600714	2	44	theme	nanofibrils	481:491	arg1	composite					500:508	gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite	450:508	gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL)	450:584	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	0	45	theme	gum/lignocellulose	18:35	arg1	hydrogels					49:57	Injectable gellan gum/lignocellulose nanofibrils hydrogels	0:57	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded	0:88	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies.
32600714	3	46	theme	%	794:794	arg1	FS-MEL					796:801	0.1-0.3 w/v% FS-MEL	783:801	0.1-0.3 w/v% FS-MEL	783:801	Gelation time and temperature were determined for different hydrogel formulation containing 1-5 w/v% LGNF and 0.1-0.3 w/v% FS-MEL.
32600714	5	47	theme	FS	994:995	arg1	effect					975:980	the effect	971:980	the effect of LGNF and FS on hydrogel behaviour	971:1017	Degradation rate and swelling degree of developed hydrogel were evaluated to determine the effect of LGNF and FS on hydrogel behaviour.
32600714	3	48	contain	containing	754:763	arg2	LGNF					774:777	1-5 w/v% LGNF	765:777	1-5 w/v% LGNF	765:777	Gelation time and temperature were determined for different hydrogel formulation containing 1-5 w/v% LGNF and 0.1-0.3 w/v% FS-MEL.
32600714	3	48	contain	containing	754:763	arg1	formulation					742:752	different hydrogel formulation	723:752	different hydrogel formulation containing 1-5 w/v% LGNF and 0.1-0.3 w/v% FS-MEL	723:801	Gelation time and temperature were determined for different hydrogel formulation containing 1-5 w/v% LGNF and 0.1-0.3 w/v% FS-MEL.
32600714	3	48	contain	containing	754:763	arg2	FS-MEL					796:801	0.1-0.3 w/v% FS-MEL	783:801	0.1-0.3 w/v% FS-MEL	783:801	Gelation time and temperature were determined for different hydrogel formulation containing 1-5 w/v% LGNF and 0.1-0.3 w/v% FS-MEL.
32600714	7	49	from	results	1175:1181	arg1	PBS					1207:1209	PBS	1207:1209	PBS	1207:1209	The results of MEL release study in PBS revealed that MEL showed more sustained release from the hydrogel compared to FS nanoparticles.
32600714	2	50	theme	/lignocellulose	465:479	arg1	composite					500:508	gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite	450:508	gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL)	450:584	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	7	51	theme	study	1198:1202	arg1	results					1175:1181	The results	1171:1181	The results of MEL release study in PBS	1171:1209	The results of MEL release study in PBS revealed that MEL showed more sustained release from the hydrogel compared to FS nanoparticles.
32600714	1	52	theme	mineral	363:369	arg1	nanofilers					371:380	mineral nanofilers	363:380	mineral nanofilers carrying drug molecules	363:404	Injectable hydrogels based on natural polysaccharides have attracted considerable attention in cartilage tissue engineering, especially those reinforced with mineral nanofilers carrying drug molecules.
32600714	4	53	theme	developed	863:871	arg1	hydrogels					873:881	the developed hydrogels	859:881	the developed hydrogels	859:881	The injectability test proved the ease of injection of the developed hydrogels.
32600714	9	54	theme	synergic	1548:1555	arg1	effect					1557:1562	the synergic effect	1544:1562	the synergic effect of FS and MEL	1544:1576	Results exhibited higher cell adhesion, proliferation and gene expression on GG/LGNF/FS-MEL hydrogel compared to GG/LGNF and GG/LGNF/FS, which can be attributed to the synergic effect of FS and MEL.
32600714	2	55	theme	melatonin	524:532	arg1	FS-MEL					578:583	FS-MEL	578:583	FS-MEL	578:583	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	2	55	theme	melatonin	524:532	arg1	nanoparticles					563:575	melatonin (MEL) loaded forsterite (FS) nanoparticles	524:575	melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL)	524:584	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	9	56	dep	exhibited	1388:1396	arg1	compared					1481:1488	compared	1481:1488	compared to GG/LGNF and GG/LGNF/FS, which can be attributed to the synergic effect of FS and MEL	1481:1576	Results exhibited higher cell adhesion, proliferation and gene expression on GG/LGNF/FS-MEL hydrogel compared to GG/LGNF and GG/LGNF/FS, which can be attributed to the synergic effect of FS and MEL.
32600714	2	57	dep	mechanical	618:627	arg1	enhanced					609:616	enhanced	609:616	enhanced	609:616	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	3	58	theme	Gelation	673:680	arg1	time					682:685	Gelation time	673:685	Gelation time	673:685	Gelation time and temperature were determined for different hydrogel formulation containing 1-5 w/v% LGNF and 0.1-0.3 w/v% FS-MEL.
32600714	2	59	theme	LGNF	494:497	arg1	composite					500:508	gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite	450:508	gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL)	450:584	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	5	60	theme	swelling	905:912	arg1	degree					914:919	swelling degree	905:919	swelling degree	905:919	Degradation rate and swelling degree of developed hydrogel were evaluated to determine the effect of LGNF and FS on hydrogel behaviour.
32600714	7	61	theme	MEL	1186:1188	arg1	release					1190:1196	MEL release	1186:1196	MEL release study in PBS	1186:1209	The results of MEL release study in PBS revealed that MEL showed more sustained release from the hydrogel compared to FS nanoparticles.
32600714	7	62	theme	sustained	1241:1249	arg1	release					1251:1257	more sustained release	1236:1257	more sustained release from the hydrogel	1236:1275	The results of MEL release study in PBS revealed that MEL showed more sustained release from the hydrogel compared to FS nanoparticles.
32600714	0	63	theme	culture	188:194	arg1	studies					196:202	cell culture studies	183:202	cell culture studies	183:202	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies.
32600714	10	64	theme	developed	1617:1625	arg1	materials					1680:1688	promising materials	1670:1688	promising materials for cartilage regeneration applications	1670:1728	Overall results demonstrated that the developed GG/LGNF/FS-MEL hydrogels can be offered as promising materials for cartilage regeneration applications.
32600714	10	64	theme	developed	1617:1625	arg1	hydrogels					1642:1650	the developed GG/LGNF/FS-MEL hydrogels	1613:1650	the developed GG/LGNF/FS-MEL hydrogels	1613:1650	Overall results demonstrated that the developed GG/LGNF/FS-MEL hydrogels can be offered as promising materials for cartilage regeneration applications.
32600714	7	65	theme	release	1190:1196	arg1	study					1198:1202	MEL release study	1186:1202	MEL release study in PBS	1186:1209	The results of MEL release study in PBS revealed that MEL showed more sustained release from the hydrogel compared to FS nanoparticles.
32600714	1	66	theme	drug	391:394	arg1	molecules					396:404	drug molecules	391:404	drug molecules	391:404	Injectable hydrogels based on natural polysaccharides have attracted considerable attention in cartilage tissue engineering, especially those reinforced with mineral nanofilers carrying drug molecules.
32600714	0	67	theme	cell	183:186	arg1	studies					196:202	cell culture studies	183:202	cell culture studies	183:202	Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies.
32600714	4	68	theme	hydrogels	873:881	arg1	injection					846:854	injection	846:854	injection of the developed hydrogels	846:881	The injectability test proved the ease of injection of the developed hydrogels.
32600714	9	69	theme	FS	1567:1568	arg1	effect					1557:1562	the synergic effect	1544:1562	the synergic effect of FS and MEL	1544:1576	Results exhibited higher cell adhesion, proliferation and gene expression on GG/LGNF/FS-MEL hydrogel compared to GG/LGNF and GG/LGNF/FS, which can be attributed to the synergic effect of FS and MEL.
32600714	10	70	theme	Overall	1579:1585	arg1	results					1587:1593	Overall results	1579:1593	Overall results	1579:1593	Overall results demonstrated that the developed GG/LGNF/FS-MEL hydrogels can be offered as promising materials for cartilage regeneration applications.
32600714	3	71	theme	different	723:731	arg1	formulation					742:752	different hydrogel formulation	723:752	different hydrogel formulation containing 1-5 w/v% LGNF and 0.1-0.3 w/v% FS-MEL	723:801	Gelation time and temperature were determined for different hydrogel formulation containing 1-5 w/v% LGNF and 0.1-0.3 w/v% FS-MEL.
32600714	9	72	theme	MEL	1574:1576	arg1	effect					1557:1562	the synergic effect	1544:1562	the synergic effect of FS and MEL	1544:1576	Results exhibited higher cell adhesion, proliferation and gene expression on GG/LGNF/FS-MEL hydrogel compared to GG/LGNF and GG/LGNF/FS, which can be attributed to the synergic effect of FS and MEL.
32600714	1	73	theme	considerable	274:285	arg1	attention					287:295	considerable attention	274:295	considerable attention	274:295	Injectable hydrogels based on natural polysaccharides have attracted considerable attention in cartilage tissue engineering, especially those reinforced with mineral nanofilers carrying drug molecules.
32600714	7	74	from	hydrogel	1268:1275	arg1	release					1251:1257	more sustained release	1236:1257	more sustained release from the hydrogel	1236:1275	The results of MEL release study in PBS revealed that MEL showed more sustained release from the hydrogel compared to FS nanoparticles.
32600714	5	75	theme	LGNF	985:988	arg1	effect					975:980	the effect	971:980	the effect of LGNF and FS on hydrogel behaviour	971:1017	Degradation rate and swelling degree of developed hydrogel were evaluated to determine the effect of LGNF and FS on hydrogel behaviour.
32600714	2	76	theme	forsterite	547:556	arg1	FS-MEL					578:583	FS-MEL	578:583	FS-MEL	578:583	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	2	76	theme	forsterite	547:556	arg1	nanoparticles					563:575	melatonin (MEL) loaded forsterite (FS) nanoparticles	524:575	melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL)	524:584	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	1	77	theme	natural	235:241	arg1	polysaccharides					243:257	natural polysaccharides	235:257	natural polysaccharides	235:257	Injectable hydrogels based on natural polysaccharides have attracted considerable attention in cartilage tissue engineering, especially those reinforced with mineral nanofilers carrying drug molecules.
32600714	6	78	theme	FS	1167:1168	arg1	incorporation					1141:1153	incorporation	1141:1153	incorporation of LGNF and FS	1141:1168	Results of mechanical characterization showed that the compressive modulus and strength of GG hydrogels were improved by incorporation of LGNF and FS.
32600714	6	79	theme	compressive	1075:1085	arg1	modulus					1087:1093	the compressive modulus	1071:1093	the compressive modulus	1071:1093	Results of mechanical characterization showed that the compressive modulus and strength of GG hydrogels were improved by incorporation of LGNF and FS.
32600714	2	80	theme	loaded	540:545	arg1	FS-MEL					578:583	FS-MEL	578:583	FS-MEL	578:583	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	2	80	theme	loaded	540:545	arg1	nanoparticles					563:575	melatonin (MEL) loaded forsterite (FS) nanoparticles	524:575	melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL)	524:584	Here, a novel injectable hydrogel based on gellan gum (GG)/lignocellulose nanofibrils (LGNF) composite enriched with melatonin (MEL) loaded forsterite (FS) nanoparticles (FS-MEL) was developed to yield enhanced mechanical and biological properties of the hydrogels.
32600714	4	81	theme	injection	846:854	arg1	ease					838:841	the ease	834:841	the ease of injection of the developed hydrogels	834:881	The injectability test proved the ease of injection of the developed hydrogels.
32600714	9	82	theme	GG/LGNF/FS-MEL	1457:1470	arg1	hydrogel					1472:1479	GG/LGNF/FS-MEL hydrogel	1457:1479	GG/LGNF/FS-MEL hydrogel	1457:1479	Results exhibited higher cell adhesion, proliferation and gene expression on GG/LGNF/FS-MEL hydrogel compared to GG/LGNF and GG/LGNF/FS, which can be attributed to the synergic effect of FS and MEL.
32600714	1	83	theme	cartilage	300:308	arg1	engineering					317:327	cartilage tissue engineering	300:327	cartilage tissue engineering	300:327	Injectable hydrogels based on natural polysaccharides have attracted considerable attention in cartilage tissue engineering, especially those reinforced with mineral nanofilers carrying drug molecules.
32600714	1	83	theme	cartilage	300:308	arg1	those					341:345	those	341:345	those	341:345	Injectable hydrogels based on natural polysaccharides have attracted considerable attention in cartilage tissue engineering, especially those reinforced with mineral nanofilers carrying drug molecules.
34639147	5	0	contain	contain	806:812	arg2	impurities					833:842	any hard-to-remove impurities	814:842	any hard-to-remove impurities	814:842	Importantly, the BC obtained from PJ was not cytotoxic against fibroblast cell line L929 in vitro and did not contain any hard-to-remove impurities.
34639147	5	0	contain	contain	806:812	arg1	BC					713:714	the BC	709:714	the BC obtained from PJ	709:731	Importantly, the BC obtained from PJ was not cytotoxic against fibroblast cell line L929 in vitro and did not contain any hard-to-remove impurities.
34639147	5	1	theme	hard-to-remove	818:831	arg1	impurities					833:842	any hard-to-remove impurities	814:842	any hard-to-remove impurities	814:842	Importantly, the BC obtained from PJ was not cytotoxic against fibroblast cell line L929 in vitro and did not contain any hard-to-remove impurities.
34639147	1	2	theme	starch	203:208	arg1	industry					210:217	the potato starch industry	192:217	the potato starch industry	192:217	In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ).
34639147	1	2	theme	starch	203:208	arg1	juice					233:237	potato tuber juice	220:237	potato tuber juice (PJ)	220:242	In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ).
34639147	0	3	theme	Cost-Effective	44:57	arg1	Medium					59:64	a Cost-Effective Medium	42:64	a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose	42:108	Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose.
34639147	7	4	from	standpoint	1106:1115	arg1	These					1053:1057	These	1053:1057	These	1053:1057	These are very important aspects from an application standpoint, particularly in biomedicine.
34639147	7	4	from	standpoint	1106:1115	arg1	aspects					1078:1084	very important aspects	1063:1084	very important aspects	1063:1084	These are very important aspects from an application standpoint, particularly in biomedicine.
34639147	3	5	theme	PJ	467:468	arg1	medium					470:475	the PJ medium	463:475	the PJ medium (>4 g/L)	463:484	The BC yield from the PJ medium (>4 g/L) was comparable, despite the lack of any pre-treatment.
34639147	3	5	theme	PJ	467:468	arg1	g/L					481:483	>4 g/L	478:483	>4 g/L	478:483	The BC yield from the PJ medium (>4 g/L) was comparable, despite the lack of any pre-treatment.
34639147	1	6	theme	industry	210:217	arg1	product					181:187	a major waste product	167:187	a major waste product of the potato starch industry, potato tuber juice (PJ)	167:242	In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ).
34639147	8	7	theme	industry	1308:1315	arg1	product					1286:1292	an environmentally problematic waste product	1249:1292	an environmentally problematic waste product of the starch industry	1249:1315	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	4	8	dep	PJ	677:678	arg1	BC					692:693	BC	692:693	BC	692:693	Likewise, the macro- and microstructure, physicochemical parameters, and chemical composition showed no significant differences between PJ and control BC.
34639147	7	9	theme	important	1068:1076	arg1	These					1053:1057	These	1053:1057	These	1053:1057	These are very important aspects from an application standpoint, particularly in biomedicine.
34639147	7	9	theme	important	1068:1076	arg1	aspects					1078:1084	very important aspects	1063:1084	very important aspects	1063:1084	These are very important aspects from an application standpoint, particularly in biomedicine.
34639147	3	10	from	medium	470:475	arg1	yield					452:456	The BC yield	445:456	The BC yield from the PJ medium (>4 g/L)	445:484	The BC yield from the PJ medium (>4 g/L) was comparable, despite the lack of any pre-treatment.
34639147	3	10	from	medium	470:475	arg1	comparable					490:499	comparable	490:499	comparable	490:499	The BC yield from the PJ medium (>4 g/L) was comparable, despite the lack of any pre-treatment.
34639147	8	11	theme	starch	1301:1306	arg1	industry					1308:1315	the starch industry	1297:1315	the starch industry	1297:1315	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	1	12	theme	potato	220:225	arg1	industry					210:217	the potato starch industry	192:217	the potato starch industry	192:217	In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ).
34639147	1	12	theme	potato	220:225	arg1	PJ					240:241	PJ	240:241	PJ	240:241	In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ).
34639147	1	12	theme	potato	220:225	arg1	juice					233:237	potato tuber juice	220:237	potato tuber juice (PJ)	220:242	In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ).
34639147	7	13	theme	application	1094:1104	arg1	standpoint					1106:1115	an application standpoint	1091:1115	an application standpoint	1091:1115	These are very important aspects from an application standpoint, particularly in biomedicine.
34639147	6	14	dep	BC	980:981	arg1	obtained					983:990	obtained	983:990	obtained in the conventional medium	983:1017	The PJ-BC soaked with antiseptic exerted a similar antimicrobial effect against Staphylococcus aureus and Pseudomonas aeruginosa as to BC obtained in the conventional medium and supplemented with antiseptic.
34639147	6	14	dep	BC	980:981	arg1	supplemented					1023:1034	supplemented	1023:1034	supplemented with antiseptic	1023:1050	The PJ-BC soaked with antiseptic exerted a similar antimicrobial effect against Staphylococcus aureus and Pseudomonas aeruginosa as to BC obtained in the conventional medium and supplemented with antiseptic.
34639147	4	15	theme	physicochemical	582:596	arg1	parameters					598:607	physicochemical parameters	582:607	physicochemical parameters	582:607	Likewise, the macro- and microstructure, physicochemical parameters, and chemical composition showed no significant differences between PJ and control BC.
34639147	2	16	theme	conventional	397:408	arg1	medium					437:442	conventional commercial Hestrin-Schramm medium	397:442	conventional commercial Hestrin-Schramm medium	397:442	We obtained a cost-effective, ecological-friendly microbiological medium that yielded bacterial cellulose (BC) with properties equivalent to those from conventional commercial Hestrin-Schramm medium.
34639147	8	17	from	application	1392:1402	arg1	biomedicine					1426:1436	biomedicine	1426:1436	biomedicine	1426:1436	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	2	18	dep	cost-effective	259:272	arg1	microbiological					295:309	microbiological	295:309	microbiological	295:309	We obtained a cost-effective, ecological-friendly microbiological medium that yielded bacterial cellulose (BC) with properties equivalent to those from conventional commercial Hestrin-Schramm medium.
34639147	8	19	from	drop	1348:1351	arg1	costs					1370:1374	BC production costs	1356:1374	BC production costs	1356:1374	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	0	20	theme	Potato	0:5	arg1	Waste					32:36	a Starch Industry Waste	14:36	a Starch Industry Waste	14:36	Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose.
34639147	0	20	theme	Potato	0:5	arg1	Juice					7:11	Potato Juice	0:11	Potato Juice	0:11	Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose.
34639147	1	21	theme	tuber	227:231	arg1	industry					210:217	the potato starch industry	192:217	the potato starch industry	192:217	In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ).
34639147	1	21	theme	tuber	227:231	arg1	PJ					240:241	PJ	240:241	PJ	240:241	In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ).
34639147	1	21	theme	tuber	227:231	arg1	juice					233:237	potato tuber juice	220:237	potato tuber juice (PJ)	220:242	In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ).
34639147	2	22	theme	bacterial	331:339	arg1	BC					352:353	BC	352:353	BC	352:353	We obtained a cost-effective, ecological-friendly microbiological medium that yielded bacterial cellulose (BC) with properties equivalent to those from conventional commercial Hestrin-Schramm medium.
34639147	2	22	theme	bacterial	331:339	arg1	cellulose					341:349	bacterial cellulose	331:349	bacterial cellulose (BC) with properties equivalent to those from conventional commercial Hestrin-Schramm medium	331:442	We obtained a cost-effective, ecological-friendly microbiological medium that yielded bacterial cellulose (BC) with properties equivalent to those from conventional commercial Hestrin-Schramm medium.
34639147	8	23	theme	wider	1386:1390	arg1	application					1392:1402	wider application	1386:1402	wider application of this biopolymer in biomedicine	1386:1436	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	0	24	theme	Cellulose	100:108	arg1	Biosynthesis					74:85	the Biosynthesis	70:85	the Biosynthesis of Bacterial Cellulose	70:108	Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose.
34639147	8	25	theme	significant	1336:1346	arg1	drop					1348:1351	a significant drop	1334:1351	a significant drop in BC production costs	1334:1374	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	2	26	theme	equivalent	372:381	arg1	properties					361:370	properties	361:370	properties equivalent to those from conventional commercial Hestrin-Schramm medium	361:442	We obtained a cost-effective, ecological-friendly microbiological medium that yielded bacterial cellulose (BC) with properties equivalent to those from conventional commercial Hestrin-Schramm medium.
34639147	5	27	theme	fibroblast	759:768	arg1	L929					780:783	fibroblast cell line L929	759:783	fibroblast cell line L929	759:783	Importantly, the BC obtained from PJ was not cytotoxic against fibroblast cell line L929 in vitro and did not contain any hard-to-remove impurities.
34639147	6	28	theme	antimicrobial	896:908	arg1	effect					910:915	a similar antimicrobial effect	886:915	a similar antimicrobial effect against Staphylococcus aureus and Pseudomonas aeruginosa	886:972	The PJ-BC soaked with antiseptic exerted a similar antimicrobial effect against Staphylococcus aureus and Pseudomonas aeruginosa as to BC obtained in the conventional medium and supplemented with antiseptic.
34639147	0	29	theme	Bacterial	90:98	arg1	Cellulose					100:108	Bacterial Cellulose	90:108	Bacterial Cellulose	90:108	Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose.
34639147	5	30	theme	line	775:778	arg1	L929					780:783	fibroblast cell line L929	759:783	fibroblast cell line L929	759:783	Importantly, the BC obtained from PJ was not cytotoxic against fibroblast cell line L929 in vitro and did not contain any hard-to-remove impurities.
34639147	0	31	theme	Industry	23:30	arg1	Waste					32:36	a Starch Industry Waste	14:36	a Starch Industry Waste	14:36	Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose.
34639147	0	31	theme	Industry	23:30	arg1	Juice					7:11	Potato Juice	0:11	Potato Juice	0:11	Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose.
34639147	6	32	theme	similar	888:894	arg1	effect					910:915	a similar antimicrobial effect	886:915	a similar antimicrobial effect against Staphylococcus aureus and Pseudomonas aeruginosa	886:972	The PJ-BC soaked with antiseptic exerted a similar antimicrobial effect against Staphylococcus aureus and Pseudomonas aeruginosa as to BC obtained in the conventional medium and supplemented with antiseptic.
34639147	1	33	theme	major	169:173	arg1	product					181:187	a major waste product	167:187	a major waste product of the potato starch industry, potato tuber juice (PJ)	167:242	In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ).
34639147	0	34	theme	Starch	16:21	arg1	Waste					32:36	a Starch Industry Waste	14:36	a Starch Industry Waste	14:36	Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose.
34639147	0	34	theme	Starch	16:21	arg1	Juice					7:11	Potato Juice	0:11	Potato Juice	0:11	Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose.
34639147	8	35	theme	biopolymer	1412:1421	arg1	application					1392:1402	wider application	1386:1402	wider application of this biopolymer in biomedicine	1386:1436	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	3	36	theme	pre-treatment	526:538	arg1	lack					514:517	the lack	510:517	the lack of any pre-treatment	510:538	The BC yield from the PJ medium (>4 g/L) was comparable, despite the lack of any pre-treatment.
34639147	1	37	theme	waste	175:179	arg1	product					181:187	a major waste product	167:187	a major waste product of the potato starch industry, potato tuber juice (PJ)	167:242	In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ).
34639147	2	38	theme	Hestrin-Schramm	421:435	arg1	medium					437:442	conventional commercial Hestrin-Schramm medium	397:442	conventional commercial Hestrin-Schramm medium	397:442	We obtained a cost-effective, ecological-friendly microbiological medium that yielded bacterial cellulose (BC) with properties equivalent to those from conventional commercial Hestrin-Schramm medium.
34639147	8	39	theme	production	1359:1368	arg1	costs					1370:1374	BC production costs	1356:1374	BC production costs	1356:1374	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	8	40	theme	waste	1280:1284	arg1	product					1286:1292	an environmentally problematic waste product	1249:1292	an environmentally problematic waste product of the starch industry	1249:1315	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	2	41	theme	commercial	410:419	arg1	medium					437:442	conventional commercial Hestrin-Schramm medium	397:442	conventional commercial Hestrin-Schramm medium	397:442	We obtained a cost-effective, ecological-friendly microbiological medium that yielded bacterial cellulose (BC) with properties equivalent to those from conventional commercial Hestrin-Schramm medium.
34639147	7	42	from	aspects	1078:1084	arg1	biomedicine					1134:1144	biomedicine	1134:1144	biomedicine	1134:1144	These are very important aspects from an application standpoint, particularly in biomedicine.
34639147	8	43	theme	BC	1356:1357	arg1	costs					1370:1374	BC production costs	1356:1374	BC production costs	1356:1374	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	4	44	theme	significant	645:655	arg1	differences					657:667	no significant differences	642:667	no significant differences between PJ and control BC	642:693	Likewise, the macro- and microstructure, physicochemical parameters, and chemical composition showed no significant differences between PJ and control BC.
34639147	2	45	theme	cost-effective	259:272	arg1	medium					311:316	a cost-effective, ecological-friendly microbiological medium	257:316	a cost-effective, ecological-friendly microbiological medium that yielded bacterial cellulose (BC) with properties equivalent to those from conventional commercial Hestrin-Schramm medium	257:442	We obtained a cost-effective, ecological-friendly microbiological medium that yielded bacterial cellulose (BC) with properties equivalent to those from conventional commercial Hestrin-Schramm medium.
34639147	6	46	theme	conventional	999:1010	arg1	medium					1012:1017	the conventional medium	995:1017	the conventional medium	995:1017	The PJ-BC soaked with antiseptic exerted a similar antimicrobial effect against Staphylococcus aureus and Pseudomonas aeruginosa as to BC obtained in the conventional medium and supplemented with antiseptic.
34639147	3	47	theme	BC	449:450	arg1	yield					452:456	The BC yield	445:456	The BC yield from the PJ medium (>4 g/L)	445:484	The BC yield from the PJ medium (>4 g/L) was comparable, despite the lack of any pre-treatment.
34639147	3	47	theme	BC	449:450	arg1	comparable					490:499	comparable	490:499	comparable	490:499	The BC yield from the PJ medium (>4 g/L) was comparable, despite the lack of any pre-treatment.
34639147	8	48	theme	problematic	1268:1278	arg1	product					1286:1292	an environmentally problematic waste product	1249:1292	an environmentally problematic waste product of the starch industry	1249:1315	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	8	49	theme	significant	1221:1231	arg1	valorization					1233:1244	significant valorization	1221:1244	significant valorization of an environmentally problematic waste product of the starch industry	1221:1315	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	0	50	dep	Juice	7:11	arg1	Medium					59:64	a Cost-Effective Medium	42:64	a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose	42:108	Potato Juice, a Starch Industry Waste, as a Cost-Effective Medium for the Biosynthesis of Bacterial Cellulose.
34639147	5	51	theme	cell	770:773	arg1	L929					780:783	fibroblast cell line L929	759:783	fibroblast cell line L929	759:783	Importantly, the BC obtained from PJ was not cytotoxic against fibroblast cell line L929 in vitro and did not contain any hard-to-remove impurities.
34639147	8	52	theme	product	1286:1292	arg1	valorization					1233:1244	significant valorization	1221:1244	significant valorization of an environmentally problematic waste product of the starch industry	1221:1315	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	8	53	theme	BC	1188:1189	arg1	biosynthesis					1191:1202	BC biosynthesis	1188:1202	BC biosynthesis	1188:1202	Therefore, we conclude that using PJ for BC biosynthesis is a path toward significant valorization of an environmentally problematic waste product of the starch industry, but also toward a significant drop in BC production costs, enabling wider application of this biopolymer in biomedicine.
34639147	2	54	with	cellulose	341:349	arg1	properties					361:370	properties	361:370	properties equivalent to those from conventional commercial Hestrin-Schramm medium	361:442	We obtained a cost-effective, ecological-friendly microbiological medium that yielded bacterial cellulose (BC) with properties equivalent to those from conventional commercial Hestrin-Schramm medium.
34639147	4	55	theme	chemical	614:621	arg1	composition					623:633	chemical composition	614:633	chemical composition	614:633	Likewise, the macro- and microstructure, physicochemical parameters, and chemical composition showed no significant differences between PJ and control BC.
34639147	1	56	theme	potato	196:201	arg1	industry					210:217	the potato starch industry	192:217	the potato starch industry	192:217	In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ).
34639147	1	56	theme	potato	196:201	arg1	juice					233:237	potato tuber juice	220:237	potato tuber juice (PJ)	220:242	In this work, we verified the possibility of valorizing a major waste product of the potato starch industry, potato tuber juice (PJ).
32941901	3	0	theme	injectable	329:338	arg1	hydrogel					367:374	injectable and self-healing composite hydrogel	329:374	injectable and self-healing composite hydrogel	329:374	Herein, a series of injectable and self-healing composite hydrogel were developed as delivery vehicles for anti-cancer drug.
32941901	5	1	theme	0.25 μm	680:686	arg1	size					666:669	particle size	657:669	particle size of about 0.25 μm	657:686	The nano γ-Fe2O3 with particle size of about 0.25 μm loaded on the surface of hydrogel.
32941901	9	2	theme	anti-cancer	1171:1181	arg1	property					1183:1190	acceptable anti-cancer property	1160:1190	acceptable anti-cancer property	1160:1190	In addition, the drug delivery systems indicated acceptable anti-cancer property though trace amounts of 5-FU were added in the hydrogel systems.
32941901	4	3	theme	anti-cancer	611:621	arg1	properties					623:632	excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties	541:632	excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties	541:632	The hydrogels were obtained with varying ratios of oxidized pectin/chitosan to nano γ-Fe2O3, which present excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties.
32941901	4	4	theme	injectable	551:560	arg1	properties					623:632	excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties	541:632	excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties	541:632	The hydrogels were obtained with varying ratios of oxidized pectin/chitosan to nano γ-Fe2O3, which present excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties.
32941901	7	5	theme	OP4-400	969:975	arg1	rate					961:964	the swelling rate	948:964	the swelling rate of OP4-400	948:975	When pH dropped from 7.4 to 6.5 or temperature increased form 36 °C to 37 °C, the percentage increase in the swelling rate of OP4-400 reached to 35.89% and 25.13%, respectively.
32941901	4	6	theme	oxidized	485:492	arg1	pectin/chitosan					494:508	oxidized pectin/chitosan	485:508	oxidized pectin/chitosan to nano γ-Fe2O3	485:524	The hydrogels were obtained with varying ratios of oxidized pectin/chitosan to nano γ-Fe2O3, which present excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties.
32941901	7	7	theme	swelling	952:959	arg1	rate					961:964	the swelling rate	948:964	the swelling rate of OP4-400	948:975	When pH dropped from 7.4 to 6.5 or temperature increased form 36 °C to 37 °C, the percentage increase in the swelling rate of OP4-400 reached to 35.89% and 25.13%, respectively.
32941901	4	8	theme	excellent	541:549	arg1	properties					623:632	excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties	541:632	excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties	541:632	The hydrogels were obtained with varying ratios of oxidized pectin/chitosan to nano γ-Fe2O3, which present excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties.
32941901	5	9	theme	nano	639:642	arg1	γ-Fe2O3					644:650	The nano γ-Fe2O3	635:650	The nano γ-Fe2O3 with particle size of about 0.25 μm	635:686	The nano γ-Fe2O3 with particle size of about 0.25 μm loaded on the surface of hydrogel.
32941901	4	10	theme	nano	513:516	arg1	γ-Fe2O3					518:524	nano γ-Fe2O3	513:524	nano γ-Fe2O3	513:524	The hydrogels were obtained with varying ratios of oxidized pectin/chitosan to nano γ-Fe2O3, which present excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties.
32941901	7	11	dep	6.5	871:873	arg1	to					868:869	to	868:869	to	868:869	When pH dropped from 7.4 to 6.5 or temperature increased form 36 °C to 37 °C, the percentage increase in the swelling rate of OP4-400 reached to 35.89% and 25.13%, respectively.
32941901	9	12	theme	trace	1199:1203	arg1	5-FU					1216:1219	5-FU	1216:1219	5-FU	1216:1219	In addition, the drug delivery systems indicated acceptable anti-cancer property though trace amounts of 5-FU were added in the hydrogel systems.
32941901	9	12	theme	trace	1199:1203	arg1	amounts					1205:1211	trace amounts	1199:1211	trace amounts of 5-FU	1199:1219	In addition, the drug delivery systems indicated acceptable anti-cancer property though trace amounts of 5-FU were added in the hydrogel systems.
32941901	10	13	theme	γ-Fe2O3	1273:1279	arg1	beneficial					1299:1308	beneficial	1299:1308	beneficial	1299:1308	The addition of γ-Fe2O3 could not only be beneficial to the targeting but also collectively enhance the anti-cancer property.
32941901	10	13	theme	γ-Fe2O3	1273:1279	arg1	addition					1261:1268	The addition	1257:1268	The addition of γ-Fe2O3	1257:1279	The addition of γ-Fe2O3 could not only be beneficial to the targeting but also collectively enhance the anti-cancer property.
32941901	3	14	theme	hydrogel	367:374	arg1	series					319:324	a series	317:324	a series of injectable and self-healing composite hydrogel	317:374	Herein, a series of injectable and self-healing composite hydrogel were developed as delivery vehicles for anti-cancer drug.
32941901	3	14	theme	hydrogel	367:374	arg1	vehicles					403:410	delivery vehicles	394:410	delivery vehicles for anti-cancer drug	394:431	Herein, a series of injectable and self-healing composite hydrogel were developed as delivery vehicles for anti-cancer drug.
32941901	7	15	from	increase	936:943	arg1	rate					961:964	the swelling rate	948:964	the swelling rate of OP4-400	948:975	When pH dropped from 7.4 to 6.5 or temperature increased form 36 °C to 37 °C, the percentage increase in the swelling rate of OP4-400 reached to 35.89% and 25.13%, respectively.
32941901	5	16	theme	particle	657:664	arg1	size					666:669	particle size	657:669	particle size of about 0.25 μm	657:686	The nano γ-Fe2O3 with particle size of about 0.25 μm loaded on the surface of hydrogel.
32941901	1	17	theme	Injectable	83:92	arg1	hydrogels					94:102	Injectable hydrogels	83:102	Injectable hydrogels with self-healing ability	83:128	Injectable hydrogels with self-healing ability present great potential for drug delivery.
32941901	8	18	theme	composite	1025:1033	arg1	hydrogels					1035:1043	The composite hydrogels	1021:1043	The composite hydrogels	1021:1043	The composite hydrogels could continuously release water-soluble 5-FU for more than 12 h.
32941901	9	19	theme	5-FU	1216:1219	arg1	5-FU					1216:1219	5-FU	1216:1219	5-FU	1216:1219	In addition, the drug delivery systems indicated acceptable anti-cancer property though trace amounts of 5-FU were added in the hydrogel systems.
32941901	9	19	theme	5-FU	1216:1219	arg1	amounts					1205:1211	trace amounts	1199:1211	trace amounts of 5-FU	1199:1219	In addition, the drug delivery systems indicated acceptable anti-cancer property though trace amounts of 5-FU were added in the hydrogel systems.
32941901	2	20	theme	target	295:300	arg1	sites					302:306	target sites	295:306	target sites	295:306	They could be facilely implanted in vivo and maintained structural and functional integrity till the hydrogel arriving at target sites.
32941901	6	21	theme	hysteresis	732:741	arg1	loops					743:747	Magnetic hysteresis loops	723:747	Magnetic hysteresis loops of the hydrogel	723:763	Magnetic hysteresis loops of the hydrogel presented S-shape over the applied magnetics and the MS value was 4.86 emu/g.
32941901	0	22	theme	injectable	3:12	arg1	system					37:42	An injectable, self-healing hydrogel system	0:42	An injectable, self-healing hydrogel system from oxidized pectin/chitosan/γ-Fe2O3	0:80	An injectable, self-healing hydrogel system from oxidized pectin/chitosan/γ-Fe2O3.
32941901	8	23	theme	water-soluble	1072:1084	arg1	5-FU					1086:1089	water-soluble 5-FU	1072:1089	water-soluble 5-FU for more than 12 h	1072:1108	The composite hydrogels could continuously release water-soluble 5-FU for more than 12 h.
32941901	6	24	theme	MS	818:819	arg1	4.86 emu/g					831:840	4.86 emu/g	831:840	4.86 emu/g	831:840	Magnetic hysteresis loops of the hydrogel presented S-shape over the applied magnetics and the MS value was 4.86 emu/g.
32941901	6	24	theme	MS	818:819	arg1	value					821:825	the MS value	814:825	the MS value	814:825	Magnetic hysteresis loops of the hydrogel presented S-shape over the applied magnetics and the MS value was 4.86 emu/g.
32941901	6	25	theme	Magnetic	723:730	arg1	loops					743:747	Magnetic hysteresis loops	723:747	Magnetic hysteresis loops of the hydrogel	723:763	Magnetic hysteresis loops of the hydrogel presented S-shape over the applied magnetics and the MS value was 4.86 emu/g.
32941901	3	26	theme	anti-cancer	416:426	arg1	drug					428:431	anti-cancer drug	416:431	anti-cancer drug	416:431	Herein, a series of injectable and self-healing composite hydrogel were developed as delivery vehicles for anti-cancer drug.
32941901	1	27	theme	self-healing	109:120	arg1	ability					122:128	self-healing ability	109:128	self-healing ability	109:128	Injectable hydrogels with self-healing ability present great potential for drug delivery.
32941901	3	28	theme	delivery	394:401	arg1	series					319:324	a series	317:324	a series of injectable and self-healing composite hydrogel	317:374	Herein, a series of injectable and self-healing composite hydrogel were developed as delivery vehicles for anti-cancer drug.
32941901	3	28	theme	delivery	394:401	arg1	vehicles					403:410	delivery vehicles	394:410	delivery vehicles for anti-cancer drug	394:431	Herein, a series of injectable and self-healing composite hydrogel were developed as delivery vehicles for anti-cancer drug.
32941901	7	29	dep	37 °C	914:918	arg1	to					911:912	to	911:912	to	911:912	When pH dropped from 7.4 to 6.5 or temperature increased form 36 °C to 37 °C, the percentage increase in the swelling rate of OP4-400 reached to 35.89% and 25.13%, respectively.
32941901	4	30	theme	biocompatible	592:604	arg1	properties					623:632	excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties	541:632	excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties	541:632	The hydrogels were obtained with varying ratios of oxidized pectin/chitosan to nano γ-Fe2O3, which present excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties.
32941901	2	31	theme	till	265:268	arg1	integrity					255:263	structural and functional integrity	229:263	structural and functional integrity till the hydrogel arriving at target sites	229:306	They could be facilely implanted in vivo and maintained structural and functional integrity till the hydrogel arriving at target sites.
32941901	2	32	dep	till	265:268	arg1	hydrogel					274:281	the hydrogel	270:281	the hydrogel arriving at target sites	270:306	They could be facilely implanted in vivo and maintained structural and functional integrity till the hydrogel arriving at target sites.
32941901	0	33	theme	hydrogel	28:35	arg1	system					37:42	An injectable, self-healing hydrogel system	0:42	An injectable, self-healing hydrogel system from oxidized pectin/chitosan/γ-Fe2O3	0:80	An injectable, self-healing hydrogel system from oxidized pectin/chitosan/γ-Fe2O3.
32941901	4	34	theme	self-healing	563:574	arg1	properties					623:632	excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties	541:632	excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties	541:632	The hydrogels were obtained with varying ratios of oxidized pectin/chitosan to nano γ-Fe2O3, which present excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties.
32941901	1	35	with	hydrogels	94:102	arg1	ability					122:128	self-healing ability	109:128	self-healing ability	109:128	Injectable hydrogels with self-healing ability present great potential for drug delivery.
32941901	4	36	theme	pectin/chitosan	494:508	arg1	ratios					475:480	varying ratios	467:480	varying ratios	467:480	The hydrogels were obtained with varying ratios of oxidized pectin/chitosan to nano γ-Fe2O3, which present excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties.
32941901	0	37	theme	oxidized	49:56	arg1	pectin/chitosan/γ-Fe2O3					58:80	oxidized pectin/chitosan/γ-Fe2O3	49:80	oxidized pectin/chitosan/γ-Fe2O3	49:80	An injectable, self-healing hydrogel system from oxidized pectin/chitosan/γ-Fe2O3.
32941901	5	38	with	γ-Fe2O3	644:650	arg1	size					666:669	particle size	657:669	particle size of about 0.25 μm	657:686	The nano γ-Fe2O3 with particle size of about 0.25 μm loaded on the surface of hydrogel.
32941901	0	39	from	pectin/chitosan/γ-Fe2O3	58:80	arg1	system					37:42	An injectable, self-healing hydrogel system	0:42	An injectable, self-healing hydrogel system from oxidized pectin/chitosan/γ-Fe2O3	0:80	An injectable, self-healing hydrogel system from oxidized pectin/chitosan/γ-Fe2O3.
32941901	2	40	theme	functional	244:253	arg1	integrity					255:263	structural and functional integrity	229:263	structural and functional integrity till the hydrogel arriving at target sites	229:306	They could be facilely implanted in vivo and maintained structural and functional integrity till the hydrogel arriving at target sites.
32941901	6	41	theme	applied	792:798	arg1	magnetics					800:808	the applied magnetics	788:808	the applied magnetics	788:808	Magnetic hysteresis loops of the hydrogel presented S-shape over the applied magnetics and the MS value was 4.86 emu/g.
32941901	1	42	theme	great	138:142	arg1	potential					144:152	great potential	138:152	great potential for drug delivery	138:170	Injectable hydrogels with self-healing ability present great potential for drug delivery.
32941901	4	43	theme	magnetic	577:584	arg1	properties					623:632	excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties	541:632	excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties	541:632	The hydrogels were obtained with varying ratios of oxidized pectin/chitosan to nano γ-Fe2O3, which present excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties.
32941901	2	44	theme	structural	229:238	arg1	integrity					255:263	structural and functional integrity	229:263	structural and functional integrity till the hydrogel arriving at target sites	229:306	They could be facilely implanted in vivo and maintained structural and functional integrity till the hydrogel arriving at target sites.
32941901	9	45	theme	drug	1128:1131	arg1	systems					1142:1148	the drug delivery systems	1124:1148	the drug delivery systems	1124:1148	In addition, the drug delivery systems indicated acceptable anti-cancer property though trace amounts of 5-FU were added in the hydrogel systems.
32941901	9	46	theme	hydrogel	1239:1246	arg1	systems					1248:1254	the hydrogel systems	1235:1254	the hydrogel systems	1235:1254	In addition, the drug delivery systems indicated acceptable anti-cancer property though trace amounts of 5-FU were added in the hydrogel systems.
32941901	5	47	theme	hydrogel	713:720	arg1	surface					702:708	the surface	698:708	the surface of hydrogel	698:720	The nano γ-Fe2O3 with particle size of about 0.25 μm loaded on the surface of hydrogel.
32941901	9	48	theme	delivery	1133:1140	arg1	systems					1142:1148	the drug delivery systems	1124:1148	the drug delivery systems	1124:1148	In addition, the drug delivery systems indicated acceptable anti-cancer property though trace amounts of 5-FU were added in the hydrogel systems.
32941901	7	49	theme	percentage	925:934	arg1	increase					936:943	the percentage increase	921:943	the percentage increase in the swelling rate of OP4-400	921:975	When pH dropped from 7.4 to 6.5 or temperature increased form 36 °C to 37 °C, the percentage increase in the swelling rate of OP4-400 reached to 35.89% and 25.13%, respectively.
32941901	4	50	theme	varying	467:473	arg1	ratios					475:480	varying ratios	467:480	varying ratios	467:480	The hydrogels were obtained with varying ratios of oxidized pectin/chitosan to nano γ-Fe2O3, which present excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties.
32941901	9	51	theme	acceptable	1160:1169	arg1	property					1183:1190	acceptable anti-cancer property	1160:1190	acceptable anti-cancer property	1160:1190	In addition, the drug delivery systems indicated acceptable anti-cancer property though trace amounts of 5-FU were added in the hydrogel systems.
32941901	10	52	dep	could	1281:1285	arg1	only					1291:1294	only	1291:1294	only	1291:1294	The addition of γ-Fe2O3 could not only be beneficial to the targeting but also collectively enhance the anti-cancer property.
32941901	10	52	dep	could	1281:1285	arg1	enhance					1349:1355	enhance	1349:1355	enhance the anti-cancer property	1349:1380	The addition of γ-Fe2O3 could not only be beneficial to the targeting but also collectively enhance the anti-cancer property.
32941901	1	53	theme	drug	158:161	arg1	delivery					163:170	drug delivery	158:170	drug delivery	158:170	Injectable hydrogels with self-healing ability present great potential for drug delivery.
32941901	3	54	theme	self-healing	344:355	arg1	hydrogel					367:374	injectable and self-healing composite hydrogel	329:374	injectable and self-healing composite hydrogel	329:374	Herein, a series of injectable and self-healing composite hydrogel were developed as delivery vehicles for anti-cancer drug.
32941901	0	55	dep	injectable	3:12	arg1	self-healing					15:26	self-healing	15:26	self-healing	15:26	An injectable, self-healing hydrogel system from oxidized pectin/chitosan/γ-Fe2O3.
32941901	10	56	theme	anti-cancer	1361:1371	arg1	property					1373:1380	the anti-cancer property	1357:1380	the anti-cancer property	1357:1380	The addition of γ-Fe2O3 could not only be beneficial to the targeting but also collectively enhance the anti-cancer property.
32941901	3	57	theme	composite	357:365	arg1	hydrogel					367:374	injectable and self-healing composite hydrogel	329:374	injectable and self-healing composite hydrogel	329:374	Herein, a series of injectable and self-healing composite hydrogel were developed as delivery vehicles for anti-cancer drug.
32941901	6	58	theme	hydrogel	756:763	arg1	loops					743:747	Magnetic hysteresis loops	723:747	Magnetic hysteresis loops of the hydrogel	723:763	Magnetic hysteresis loops of the hydrogel presented S-shape over the applied magnetics and the MS value was 4.86 emu/g.
34596914	8	0	from	upsurge	1316:1322	arg1	thickness					1333:1341	crust thickness	1327:1341	crust thickness	1327:1341	CONCLUSION Overall, the upsurge in crust thickness and oil crystals was responsible for an increase in the hardness of the fries.
34596914	2	1	theme	moisture	449:456	arg1	properties					484:493	thermal properties	476:493	thermal properties	476:493	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	1	theme	moisture	449:456	arg1	properties					508:517	crystalline properties	496:517	crystalline properties	496:517	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	1	theme	moisture	449:456	arg1	texture					467:473	texture	467:473	texture	467:473	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	1	theme	moisture	449:456	arg1	content					438:444	the content	434:444	the content of moisture and oil	434:464	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	1	theme	moisture	449:456	arg1	microstructure					523:536	microstructure	523:536	microstructure	523:536	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	2	theme	refined	291:297	arg1	oil					308:310	refined rapeseed oil	291:310	refined rapeseed oil	291:310	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	4	3	theme	hydrogenated	895:906	arg1	oil					908:910	fully hydrogenated oil	889:910	fully hydrogenated oil	889:910	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction showed that hardness, enthalpy and relative crystallinity increased with an increase in the proportion of fully hydrogenated oil.
34596914	9	4	theme	oil	1528:1530	arg1	composition					1509:1519	the fatty acid composition	1494:1519	the fatty acid composition of the oil	1494:1530	This indicated that the texture of fries can be manipulated by altering the fatty acid composition of the oil.
34596914	10	5	theme	Chemical	1551:1558	arg1	Industry					1560:1567	Chemical Industry	1551:1567	Chemical Industry	1551:1567	© 2021 Society of Chemical Industry.
34596914	3	6	theme	refined	675:681	arg1	oil					683:685	refined oil	675:685	refined oil	675:685	RESULTS The outcomes presented that fries fried in fully hydrogenated oil had less oil absorption and moisture loss than those fried in refined oil.
34596914	8	7	from	crystals	1351:1358	arg1	thickness					1333:1341	crust thickness	1327:1341	crust thickness	1327:1341	CONCLUSION Overall, the upsurge in crust thickness and oil crystals was responsible for an increase in the hardness of the fries.
34596914	9	8	theme	acid	1504:1507	arg1	composition					1509:1519	the fatty acid composition	1494:1519	the fatty acid composition of the oil	1494:1530	This indicated that the texture of fries can be manipulated by altering the fatty acid composition of the oil.
34596914	7	9	theme	crust	1182:1186	arg1	thickness					1188:1196	the crust thickness	1178:1196	the crust thickness of the fries	1178:1209	Stereomicroscope images showed that the crust thickness of the fries increased slightly with an increase in the proportion of fully hydrogenated oil.
34596914	0	10	theme	French	68:73	arg1	texture					57:63	the texture	53:63	the texture of French	53:73	Insight into the effect of fatty acid composition on the texture of French fries.
34596914	5	11	theme	starch-lipid	935:946	arg1	complexes					948:956	starch-lipid complexes	935:956	starch-lipid complexes	935:956	However, the peaks of starch-lipid complexes were hardly observed during frying.
34596914	4	12	theme	texture	709:715	arg1	analyzer					717:724	the texture analyzer	705:724	the texture analyzer	705:724	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction showed that hardness, enthalpy and relative crystallinity increased with an increase in the proportion of fully hydrogenated oil.
34596914	2	13	theme	thermal	476:482	arg1	properties					484:493	thermal properties	476:493	thermal properties	476:493	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	3	14	contain	had	613:615	arg2	absorption					626:635	oil absorption	622:635	oil absorption	622:635	RESULTS The outcomes presented that fries fried in fully hydrogenated oil had less oil absorption and moisture loss than those fried in refined oil.
34596914	3	14	contain	had	613:615	arg1	outcomes					551:558	The outcomes	547:558	The outcomes presented that fries fried in fully hydrogenated oil	547:611	RESULTS The outcomes presented that fries fried in fully hydrogenated oil had less oil absorption and moisture loss than those fried in refined oil.
34596914	3	14	contain	had	613:615	arg2	loss					650:653	moisture loss	641:653	moisture loss	641:653	RESULTS The outcomes presented that fries fried in fully hydrogenated oil had less oil absorption and moisture loss than those fried in refined oil.
34596914	7	15	theme	hydrogenated	1274:1285	arg1	oil					1287:1289	fully hydrogenated oil	1268:1289	fully hydrogenated oil	1268:1289	Stereomicroscope images showed that the crust thickness of the fries increased slightly with an increase in the proportion of fully hydrogenated oil.
34596914	2	16	with	oil	344:346	arg1	proportions					361:371	diverse proportions	353:371	diverse proportions	353:371	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	6	17	theme	hydrogenated	1124:1135	arg1	oil					1137:1139	mixed hydrogenated oil	1118:1139	mixed hydrogenated oil	1118:1139	Furthermore, scanning electron microscopy results displayed that some physically trapped fat was observed in fries fried in mixed hydrogenated oil.
34596914	2	18	theme	diverse	353:359	arg1	proportions					361:371	diverse proportions	353:371	diverse proportions	353:371	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	1	19	theme	fries	147:151	arg1	texture					136:142	the texture	132:142	the texture of fries	132:151	BACKGROUND Several researchers have reported that the texture of fries is affected by the fatty acid composition of oil, although the mechanism of this effect is not clear.
34596914	8	20	from	increase	1383:1390	arg1	hardness					1399:1406	the hardness	1395:1406	the hardness of the fries	1395:1419	CONCLUSION Overall, the upsurge in crust thickness and oil crystals was responsible for an increase in the hardness of the fries.
34596914	6	21	theme	mixed	1118:1122	arg1	oil					1137:1139	mixed hydrogenated oil	1118:1139	mixed hydrogenated oil	1118:1139	Furthermore, scanning electron microscopy results displayed that some physically trapped fat was observed in fries fried in mixed hydrogenated oil.
34596914	2	22	theme	hydrogenated	322:333	arg1	oil					344:346	fully hydrogenated rapeseed oil	316:346	fully hydrogenated rapeseed oil	316:346	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	23	theme	oil	462:464	arg1	properties					484:493	thermal properties	476:493	thermal properties	476:493	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	23	theme	oil	462:464	arg1	properties					508:517	crystalline properties	496:517	crystalline properties	496:517	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	23	theme	oil	462:464	arg1	texture					467:473	texture	467:473	texture	467:473	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	23	theme	oil	462:464	arg1	content					438:444	the content	434:444	the content of moisture and oil	434:464	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	23	theme	oil	462:464	arg1	microstructure					523:536	microstructure	523:536	microstructure	523:536	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	3	24	theme	hydrogenated	596:607	arg1	oil					609:611	fully hydrogenated oil	590:611	fully hydrogenated oil	590:611	RESULTS The outcomes presented that fries fried in fully hydrogenated oil had less oil absorption and moisture loss than those fried in refined oil.
34596914	6	25	theme	electron	1016:1023	arg1	microscopy					1025:1034	scanning electron microscopy	1007:1034	scanning electron microscopy	1007:1034	Furthermore, scanning electron microscopy results displayed that some physically trapped fat was observed in fries fried in mixed hydrogenated oil.
34596914	5	26	theme	complexes	948:956	arg1	peaks					926:930	the peaks	922:930	the peaks of starch-lipid complexes	922:956	However, the peaks of starch-lipid complexes were hardly observed during frying.
34596914	1	27	theme	effect	234:239	arg1	mechanism					216:224	the mechanism	212:224	the mechanism of this effect	212:239	BACKGROUND Several researchers have reported that the texture of fries is affected by the fatty acid composition of oil, although the mechanism of this effect is not clear.
34596914	1	27	theme	effect	234:239	arg1	clear					248:252	clear	248:252	clear	248:252	BACKGROUND Several researchers have reported that the texture of fries is affected by the fatty acid composition of oil, although the mechanism of this effect is not clear.
34596914	6	28	theme	scanning	1007:1014	arg1	microscopy					1025:1034	scanning electron microscopy	1007:1034	scanning electron microscopy	1007:1034	Furthermore, scanning electron microscopy results displayed that some physically trapped fat was observed in fries fried in mixed hydrogenated oil.
34596914	7	29	from	increase	1238:1245	arg1	proportion					1254:1263	the proportion	1250:1263	the proportion of fully hydrogenated oil	1250:1289	Stereomicroscope images showed that the crust thickness of the fries increased slightly with an increase in the proportion of fully hydrogenated oil.
34596914	9	30	theme	fatty	1498:1502	arg1	composition					1509:1519	the fatty acid composition	1494:1519	the fatty acid composition of the oil	1494:1530	This indicated that the texture of fries can be manipulated by altering the fatty acid composition of the oil.
34596914	3	31	dep	RESULTS	539:545	arg1	had					613:615	had	613:615	had less oil absorption and moisture loss than those fried in refined oil	613:685	RESULTS The outcomes presented that fries fried in fully hydrogenated oil had less oil absorption and moisture loss than those fried in refined oil.
34596914	4	32	theme	X-ray	765:769	arg1	diffraction					771:781	X-ray diffraction	765:781	X-ray diffraction	765:781	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction showed that hardness, enthalpy and relative crystallinity increased with an increase in the proportion of fully hydrogenated oil.
34596914	2	33	theme	crystalline	496:506	arg1	properties					508:517	crystalline properties	496:517	crystalline properties	496:517	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	34	dep	fried	282:286	arg1	%					395:395	80%	393:395	80%	393:395	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	34	dep	fried	282:286	arg1	%					375:375	0%	374:375	0%	374:375	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	34	dep	fried	282:286	arg1	%					385:385	40%	383:385	40%	383:385	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	34	dep	fried	282:286	arg1	%					390:390	60%	388:390	60%	388:390	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	34	dep	fried	282:286	arg1	%					404:404	100%	401:404	100%	401:404	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	2	34	dep	fried	282:286	arg1	%					380:380	20%	378:380	20%	378:380	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	6	35	dep	results	1036:1042	arg1	displayed					1044:1052	displayed	1044:1052	results displayed that some physically trapped fat was observed in fries fried in mixed hydrogenated oil	1036:1139	Furthermore, scanning electron microscopy results displayed that some physically trapped fat was observed in fries fried in mixed hydrogenated oil.
34596914	7	36	theme	oil	1287:1289	arg1	proportion					1254:1263	the proportion	1250:1263	the proportion of fully hydrogenated oil	1250:1289	Stereomicroscope images showed that the crust thickness of the fries increased slightly with an increase in the proportion of fully hydrogenated oil.
34596914	1	37	theme	BACKGROUND	82:91	arg1	researchers					101:111	BACKGROUND Several researchers	82:111	BACKGROUND Several researchers	82:111	BACKGROUND Several researchers have reported that the texture of fries is affected by the fatty acid composition of oil, although the mechanism of this effect is not clear.
34596914	8	38	from	CONCLUSION	1292:1301	arg1	thickness					1333:1341	crust thickness	1327:1341	crust thickness	1327:1341	CONCLUSION Overall, the upsurge in crust thickness and oil crystals was responsible for an increase in the hardness of the fries.
34596914	1	39	theme	fatty	172:176	arg1	composition					183:193	the fatty acid composition	168:193	the fatty acid composition of oil	168:200	BACKGROUND Several researchers have reported that the texture of fries is affected by the fatty acid composition of oil, although the mechanism of this effect is not clear.
34596914	0	40	theme	fatty	27:31	arg1	composition					38:48	fatty acid composition	27:48	fatty acid composition	27:48	Insight into the effect of fatty acid composition on the texture of French fries.
34596914	8	41	theme	fries	1415:1419	arg1	hardness					1399:1406	the hardness	1395:1406	the hardness of the fries	1395:1419	CONCLUSION Overall, the upsurge in crust thickness and oil crystals was responsible for an increase in the hardness of the fries.
34596914	4	42	from	diffraction	771:781	arg1	results					692:698	The results	688:698	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction	688:781	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction showed that hardness, enthalpy and relative crystallinity increased with an increase in the proportion of fully hydrogenated oil.
34596914	4	43	theme	relative	818:825	arg1	crystallinity					827:839	relative crystallinity	818:839	relative crystallinity	818:839	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction showed that hardness, enthalpy and relative crystallinity increased with an increase in the proportion of fully hydrogenated oil.
34596914	1	44	theme	acid	178:181	arg1	composition					183:193	the fatty acid composition	168:193	the fatty acid composition of oil	168:200	BACKGROUND Several researchers have reported that the texture of fries is affected by the fatty acid composition of oil, although the mechanism of this effect is not clear.
34596914	2	45	theme	rapeseed	335:342	arg1	oil					344:346	fully hydrogenated rapeseed oil	316:346	fully hydrogenated rapeseed oil	316:346	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	3	46	theme	oil	622:624	arg1	absorption					626:635	oil absorption	622:635	oil absorption	622:635	RESULTS The outcomes presented that fries fried in fully hydrogenated oil had less oil absorption and moisture loss than those fried in refined oil.
34596914	8	47	theme	crust	1327:1331	arg1	thickness					1333:1341	crust thickness	1327:1341	crust thickness	1327:1341	CONCLUSION Overall, the upsurge in crust thickness and oil crystals was responsible for an increase in the hardness of the fries.
34596914	0	48	theme	composition	38:48	arg1	effect					17:22	the effect	13:22	the effect of fatty acid composition on the texture of French	13:73	Insight into the effect of fatty acid composition on the texture of French fries.
34596914	4	49	from	increase	859:866	arg1	proportion					875:884	the proportion	871:884	the proportion of fully hydrogenated oil	871:910	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction showed that hardness, enthalpy and relative crystallinity increased with an increase in the proportion of fully hydrogenated oil.
34596914	4	50	theme	differential	727:738	arg1	calorimetry					749:759	differential scanning calorimetry	727:759	differential scanning calorimetry	727:759	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction showed that hardness, enthalpy and relative crystallinity increased with an increase in the proportion of fully hydrogenated oil.
34596914	9	51	theme	fries	1457:1461	arg1	texture					1446:1452	the texture	1442:1452	the texture of fries	1442:1461	This indicated that the texture of fries can be manipulated by altering the fatty acid composition of the oil.
34596914	1	52	theme	Several	93:99	arg1	researchers					101:111	BACKGROUND Several researchers	82:111	BACKGROUND Several researchers	82:111	BACKGROUND Several researchers have reported that the texture of fries is affected by the fatty acid composition of oil, although the mechanism of this effect is not clear.
34596914	0	53	theme	acid	33:36	arg1	composition					38:48	fatty acid composition	27:48	fatty acid composition	27:48	Insight into the effect of fatty acid composition on the texture of French fries.
34596914	4	54	from	analyzer	717:724	arg1	results					692:698	The results	688:698	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction	688:781	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction showed that hardness, enthalpy and relative crystallinity increased with an increase in the proportion of fully hydrogenated oil.
34596914	4	55	from	calorimetry	749:759	arg1	results					692:698	The results	688:698	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction	688:781	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction showed that hardness, enthalpy and relative crystallinity increased with an increase in the proportion of fully hydrogenated oil.
34596914	7	56	theme	Stereomicroscope	1142:1157	arg1	images					1159:1164	Stereomicroscope images	1142:1164	Stereomicroscope images	1142:1164	Stereomicroscope images showed that the crust thickness of the fries increased slightly with an increase in the proportion of fully hydrogenated oil.
34596914	6	57	located	observed	1091:1098	arg1	fried					1109:1113	fried	1109:1113	fried	1109:1113	Furthermore, scanning electron microscopy results displayed that some physically trapped fat was observed in fries fried in mixed hydrogenated oil.
34596914	6	57	located	observed	1091:1098	arg2	fat					1083:1085	some physically trapped fat	1059:1085	some physically trapped fat	1059:1085	Furthermore, scanning electron microscopy results displayed that some physically trapped fat was observed in fries fried in mixed hydrogenated oil.
34596914	4	58	theme	scanning	740:747	arg1	calorimetry					749:759	differential scanning calorimetry	727:759	differential scanning calorimetry	727:759	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction showed that hardness, enthalpy and relative crystallinity increased with an increase in the proportion of fully hydrogenated oil.
34596914	2	59	with	oil	308:310	arg1	proportions					361:371	diverse proportions	353:371	diverse proportions	353:371	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	6	60	theme	trapped	1075:1081	arg1	fat					1083:1085	some physically trapped fat	1059:1085	some physically trapped fat	1059:1085	Furthermore, scanning electron microscopy results displayed that some physically trapped fat was observed in fries fried in mixed hydrogenated oil.
34596914	1	61	theme	oil	198:200	arg1	composition					183:193	the fatty acid composition	168:193	the fatty acid composition of oil	168:200	BACKGROUND Several researchers have reported that the texture of fries is affected by the fatty acid composition of oil, although the mechanism of this effect is not clear.
34596914	2	62	dep	analyzed	416:423	arg1	based					425:429	based	425:429	were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure	411:536	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	8	63	theme	oil	1347:1349	arg1	crystals					1351:1358	oil crystals	1347:1358	oil crystals	1347:1358	CONCLUSION Overall, the upsurge in crust thickness and oil crystals was responsible for an increase in the hardness of the fries.
34596914	7	64	theme	fries	1205:1209	arg1	thickness					1188:1196	the crust thickness	1178:1196	the crust thickness of the fries	1178:1209	Stereomicroscope images showed that the crust thickness of the fries increased slightly with an increase in the proportion of fully hydrogenated oil.
34596914	0	65	from	effect	17:22	arg1	texture					57:63	the texture	53:63	the texture of French	53:73	Insight into the effect of fatty acid composition on the texture of French fries.
34596914	8	66	theme	Overall	1303:1309	arg1	CONCLUSION					1292:1301	CONCLUSION Overall	1292:1309	CONCLUSION Overall	1292:1309	CONCLUSION Overall, the upsurge in crust thickness and oil crystals was responsible for an increase in the hardness of the fries.
34596914	2	67	theme	rapeseed	299:306	arg1	oil					308:310	refined rapeseed oil	291:310	refined rapeseed oil	291:310	In this regard, fries were fried in refined rapeseed oil and fully hydrogenated rapeseed oil with diverse proportions (0%, 20%, 40%, 60%, 80% and 100%) and were analyzed based on the content of moisture and oil, texture, thermal properties, crystalline properties and microstructure.
34596914	4	68	theme	oil	908:910	arg1	proportion					875:884	the proportion	871:884	the proportion of fully hydrogenated oil	871:910	The results from the texture analyzer, differential scanning calorimetry and X-ray diffraction showed that hardness, enthalpy and relative crystallinity increased with an increase in the proportion of fully hydrogenated oil.
34596914	3	69	theme	moisture	641:648	arg1	loss					650:653	moisture loss	641:653	moisture loss	641:653	RESULTS The outcomes presented that fries fried in fully hydrogenated oil had less oil absorption and moisture loss than those fried in refined oil.
32909739	5	0	theme	nanogel	757:763	arg1	content					765:771	nanogel content	757:771	nanogel content	757:771	Nanogels loaded with amoxicillin showed a controlled release profile dependent on nanogel content.
32909739	3	1	theme	Dynamic	361:367	arg1	scattering					375:384	Dynamic light scattering	361:384	Dynamic light scattering measurements	361:397	Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values.
32909739	0	2	from	Derivatives	9:19	arg1	Nanogels					51:58	Macromolecular Co-assembly Nanogels	24:58	Macromolecular Co-assembly Nanogels with Potential for Biomedical Applications	24:101	Chitosan Derivatives in Macromolecular Co-assembly Nanogels with Potential for Biomedical Applications.
32909739	4	3	from	temperature	643:653	arg1	sensitivity					609:619	The sensitivity	605:619	The sensitivity of nanogels at pH and temperature	605:653	The sensitivity of nanogels at pH and temperature was also evaluated.
32909739	5	4	theme	controlled	717:726	arg1	profile					736:742	a controlled release profile	715:742	a controlled release profile dependent on nanogel content	715:771	Nanogels loaded with amoxicillin showed a controlled release profile dependent on nanogel content.
32909739	2	5	theme	structures	349:358	arg1	composition					326:336	the composition	322:336	the composition of the new structures	322:358	Thus, the physicochemical properties were investigated and correlated with the composition of the new structures.
32909739	5	6	theme	release	728:734	arg1	profile					736:742	a controlled release profile	715:742	a controlled release profile dependent on nanogel content	715:771	Nanogels loaded with amoxicillin showed a controlled release profile dependent on nanogel content.
32909739	6	7	theme	in	887:888	arg1	biocompatibility					895:910	good in vivo biocompatibility	882:910	good in vivo biocompatibility	882:910	The formulations loaded with amoxicillin had antibacterial properties, and the cytotoxicity tests indicated good in vivo biocompatibility.
32909739	7	8	theme	synthesized	936:946	arg1	nanogels					964:971	the new synthesized polyelectrolyte nanogels	928:971	the new synthesized polyelectrolyte nanogels	928:971	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	7	8	theme	synthesized	936:946	arg1	platform					1074:1081	a multifunctional platform	1056:1081	a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution	1056:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	4	9	from	pH	636:637	arg1	sensitivity					609:619	The sensitivity	605:619	The sensitivity of nanogels at pH and temperature	605:653	The sensitivity of nanogels at pH and temperature was also evaluated.
32909739	7	10	theme	poor	1176:1179	arg1	biodistribution					1181:1195	a very poor biodistribution	1169:1195	a very poor biodistribution	1169:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	6	11	theme	good	882:885	arg1	biocompatibility					895:910	good in vivo biocompatibility	882:910	good in vivo biocompatibility	882:910	The formulations loaded with amoxicillin had antibacterial properties, and the cytotoxicity tests indicated good in vivo biocompatibility.
32909739	3	12	theme	zeta	582:585	arg1	values					597:602	positive zeta potential values	573:602	positive zeta potential values	573:602	Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values.
32909739	7	13	theme	polyelectrolyte	948:962	arg1	nanogels					964:971	the new synthesized polyelectrolyte nanogels	928:971	the new synthesized polyelectrolyte nanogels	928:971	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	7	13	theme	polyelectrolyte	948:962	arg1	platform					1074:1081	a multifunctional platform	1056:1081	a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution	1056:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	7	14	theme	encapsulated	1021:1032	arg1	drugs					1034:1038	the encapsulated drugs	1017:1038	the encapsulated drugs	1017:1038	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	3	15	theme	potential	587:595	arg1	values					597:602	positive zeta potential values	573:602	positive zeta potential values	573:602	Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values.
32909739	7	16	used	used	1048:1051	arg2	nanogels					964:971	the new synthesized polyelectrolyte nanogels	928:971	the new synthesized polyelectrolyte nanogels	928:971	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	7	16	used	used	1048:1051	arg2	platform					1074:1081	a multifunctional platform	1056:1081	a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution	1056:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	3	17	theme	microscopy	438:447	arg1	images					449:454	transmission electron microscopy images	416:454	transmission electron microscopy images	416:454	Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values.
32909739	3	18	theme	light	369:373	arg1	scattering					375:384	Dynamic light scattering	361:384	Dynamic light scattering measurements	361:397	Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values.
32909739	1	19	theme	Maleoyl-chitosan/poly	104:124	arg1	nanogels					141:148	Maleoyl-chitosan/poly(aspartic acid) nanogels	104:148	Maleoyl-chitosan/poly(aspartic acid) nanogels	104:148	Maleoyl-chitosan/poly(aspartic acid) nanogels were developed and characterized in order to assess its suitability for biomedical applications.
32909739	7	20	theme	new	932:934	arg1	nanogels					964:971	the new synthesized polyelectrolyte nanogels	928:971	the new synthesized polyelectrolyte nanogels	928:971	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	7	20	theme	new	932:934	arg1	platform					1074:1081	a multifunctional platform	1056:1081	a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution	1056:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	3	21	theme	size	484:487	arg1	distribution					489:500	nanogels size distribution	475:500	nanogels size distribution	475:500	Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values.
32909739	6	22	theme	cytotoxicity	853:864	arg1	tests					866:870	the cytotoxicity tests	849:870	the cytotoxicity tests	849:870	The formulations loaded with amoxicillin had antibacterial properties, and the cytotoxicity tests indicated good in vivo biocompatibility.
32909739	2	23	theme	new	345:347	arg1	structures					349:358	the new structures	341:358	the new structures	341:358	Thus, the physicochemical properties were investigated and correlated with the composition of the new structures.
32909739	6	24	dep	in	887:888	arg1	vivo					890:893	vivo	890:893	vivo	890:893	The formulations loaded with amoxicillin had antibacterial properties, and the cytotoxicity tests indicated good in vivo biocompatibility.
32909739	3	25	theme	transmission	416:427	arg1	microscopy					438:447	transmission electron microscopy	416:447	transmission electron microscopy images	416:454	Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values.
32909739	1	26	theme	aspartic	126:133	arg1	Maleoyl-chitosan/poly					104:124	Maleoyl-chitosan/poly	104:124	Maleoyl-chitosan/poly(aspartic acid) nanogels	104:148	Maleoyl-chitosan/poly(aspartic acid) nanogels were developed and characterized in order to assess its suitability for biomedical applications.
32909739	1	26	theme	aspartic	126:133	arg1	acid					135:138	aspartic acid	126:138	aspartic acid	126:138	Maleoyl-chitosan/poly(aspartic acid) nanogels were developed and characterized in order to assess its suitability for biomedical applications.
32909739	3	27	theme	electron	429:436	arg1	microscopy					438:447	transmission electron microscopy	416:447	transmission electron microscopy images	416:454	Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values.
32909739	4	28	theme	nanogels	624:631	arg1	sensitivity					609:619	The sensitivity	605:619	The sensitivity of nanogels at pH and temperature	605:653	The sensitivity of nanogels at pH and temperature was also evaluated.
32909739	7	29	contain	have	1164:1167	arg1	antibiotics					1147:1157	antibiotics	1147:1157	antibiotics that have a very poor biodistribution	1147:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	7	29	contain	have	1164:1167	arg2	biodistribution					1181:1195	a very poor biodistribution	1169:1195	a very poor biodistribution	1169:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	1	30	theme	biomedical	222:231	arg1	applications					233:244	biomedical applications	222:244	biomedical applications	222:244	Maleoyl-chitosan/poly(aspartic acid) nanogels were developed and characterized in order to assess its suitability for biomedical applications.
32909739	7	31	from	administration	1087:1100	arg1	spectrum					1135:1142	the spectrum	1131:1142	the spectrum of antibiotics that have a very poor biodistribution	1131:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	2	32	theme	physicochemical	257:271	arg1	properties					273:282	the physicochemical properties	253:282	the physicochemical properties	253:282	Thus, the physicochemical properties were investigated and correlated with the composition of the new structures.
32909739	0	33	theme	Co-assembly	39:49	arg1	Nanogels					51:58	Macromolecular Co-assembly Nanogels	24:58	Macromolecular Co-assembly Nanogels with Potential for Biomedical Applications	24:101	Chitosan Derivatives in Macromolecular Co-assembly Nanogels with Potential for Biomedical Applications.
32909739	3	34	theme	nanogels	475:482	arg1	distribution					489:500	nanogels size distribution	475:500	nanogels size distribution	475:500	Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values.
32909739	0	35	theme	Macromolecular	24:37	arg1	Nanogels					51:58	Macromolecular Co-assembly Nanogels	24:58	Macromolecular Co-assembly Nanogels with Potential for Biomedical Applications	24:101	Chitosan Derivatives in Macromolecular Co-assembly Nanogels with Potential for Biomedical Applications.
32909739	3	36	theme	average	518:524	arg1	diameter					526:533	average diameter	518:533	average diameter between 186 and 246 nm	518:556	Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values.
32909739	7	37	theme	antimicrobial	1105:1117	arg1	agents					1119:1124	antimicrobial agents	1105:1124	antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution	1105:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	7	38	theme	antibiotics	1147:1157	arg1	spectrum					1135:1142	the spectrum	1131:1142	the spectrum of antibiotics that have a very poor biodistribution	1131:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	6	39	contain	had	815:817	arg2	properties					833:842	antibacterial properties	819:842	antibacterial properties	819:842	The formulations loaded with amoxicillin had antibacterial properties, and the cytotoxicity tests indicated good in vivo biocompatibility.
32909739	6	39	contain	had	815:817	arg1	formulations					778:789	The formulations	774:789	The formulations loaded with amoxicillin	774:813	The formulations loaded with amoxicillin had antibacterial properties, and the cytotoxicity tests indicated good in vivo biocompatibility.
32909739	5	40	theme	dependent	744:752	arg1	profile					736:742	a controlled release profile	715:742	a controlled release profile dependent on nanogel content	715:771	Nanogels loaded with amoxicillin showed a controlled release profile dependent on nanogel content.
32909739	7	41	theme	stable	994:999	arg1	environment					1001:1011	a stable environment	992:1011	a stable environment for the encapsulated drugs	992:1038	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	7	42	theme	agents	1119:1124	arg1	administration					1087:1100	administration	1087:1100	administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution	1087:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	6	43	theme	antibacterial	819:831	arg1	properties					833:842	antibacterial properties	819:842	antibacterial properties	819:842	The formulations loaded with amoxicillin had antibacterial properties, and the cytotoxicity tests indicated good in vivo biocompatibility.
32909739	3	44	with	narrow	506:511	arg1	diameter					526:533	average diameter	518:533	average diameter between 186 and 246 nm	518:556	Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values.
32909739	7	45	theme	multifunctional	1058:1072	arg1	nanogels					964:971	the new synthesized polyelectrolyte nanogels	928:971	the new synthesized polyelectrolyte nanogels	928:971	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	7	45	theme	multifunctional	1058:1072	arg1	platform					1074:1081	a multifunctional platform	1056:1081	a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution	1056:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	0	46	theme	Biomedical	79:88	arg1	Applications					90:101	Biomedical Applications	79:101	Biomedical Applications	79:101	Chitosan Derivatives in Macromolecular Co-assembly Nanogels with Potential for Biomedical Applications.
32909739	3	47	theme	scattering	375:384	arg1	measurements					386:397	Dynamic light scattering measurements	361:397	Dynamic light scattering measurements	361:397	Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values.
32909739	0	48	with	Nanogels	51:58	arg1	Potential					65:73	Potential	65:73	Potential for Biomedical Applications	65:101	Chitosan Derivatives in Macromolecular Co-assembly Nanogels with Potential for Biomedical Applications.
32909739	3	49	theme	positive	573:580	arg1	values					597:602	positive zeta potential values	573:602	positive zeta potential values	573:602	Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values.
32909739	7	50	from	spectrum	1135:1142	arg1	administration					1087:1100	administration	1087:1100	administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution	1087:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
32909739	7	50	from	spectrum	1135:1142	arg1	agents					1119:1124	antimicrobial agents	1105:1124	antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution	1105:1195	In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.
34273340	0	0	theme	enhanced	77:84	arg1	effect					100:105	greatly enhanced antibacterial effect	69:105	greatly enhanced antibacterial effect	69:105	In situ growth zeolite imidazole framework materials on chitosan for greatly enhanced antibacterial effect.
34273340	4	1	contain	has	643:645	arg2	activity					670:677	the best antibacterial activity	647:677	the best antibacterial activity	647:677	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	4	1	contain	has	643:645	arg1	1:6					638:640	1:6	638:640	1:6	638:640	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	4	1	contain	has	643:645	arg1	CS/ZIF-67					628:636	CS/ZIF-67	628:636	CS/ZIF-67(1:6)	628:641	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	2	2	theme	easy	349:352	arg1	aggregation					354:364	easy aggregation	349:364	easy aggregation	349:364	However, powder ZIFs materials have the disadvantages of difficult separation and easy aggregation, which limit their application.
34273340	5	3	theme	excellent	1116:1124	arg1	bio-compatibility					1126:1142	excellent bio-compatibility	1116:1142	excellent bio-compatibility	1116:1142	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	4	4	theme	ZIFs	538:541	arg1	synergism					518:526	The synergism	514:526	The synergism of CS and ZIFs	514:541	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	4	5	dep	rate	699:702	arg1	15 h					708:711	in 15 h	705:711	in 15 h	705:711	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	1	6	theme	good	240:243	arg1	effect					259:264	good antibacterial effect	240:264	good antibacterial effect	240:264	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	2	7	theme	powder	276:281	arg1	materials					288:296	powder ZIFs materials	276:296	powder ZIFs materials	276:296	However, powder ZIFs materials have the disadvantages of difficult separation and easy aggregation, which limit their application.
34273340	2	8	theme	ZIFs	283:286	arg1	materials					288:296	powder ZIFs materials	276:296	powder ZIFs materials	276:296	However, powder ZIFs materials have the disadvantages of difficult separation and easy aggregation, which limit their application.
34273340	1	9	theme	antibacterial	245:257	arg1	effect					259:264	good antibacterial effect	240:264	good antibacterial effect	240:264	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	0	10	theme	antibacterial	86:98	arg1	effect					100:105	greatly enhanced antibacterial effect	69:105	greatly enhanced antibacterial effect	69:105	In situ growth zeolite imidazole framework materials on chitosan for greatly enhanced antibacterial effect.
34273340	4	11	theme	aureus	766:771	arg1	rate					755:758	the inhibitory rate	740:758	the inhibitory rate of S. aureus	740:771	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	5	12	theme	membrane	851:858	arg1	rupture					860:866	bacterial cell membrane rupture	836:866	bacterial cell membrane rupture	836:866	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	1	13	theme	imidazole	116:124	arg1	materials					136:144	Zeolite imidazole framework materials	108:144	Zeolite imidazole framework materials (ZIFs)	108:151	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	1	13	theme	imidazole	116:124	arg1	type					163:166	a new type	157:166	a new type of antibacterial material with high chemical and thermal stability	157:233	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	1	13	theme	imidazole	116:124	arg1	ZIFs					147:150	ZIFs	147:150	ZIFs	147:150	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	3	14	theme	new	489:491	arg1	agent					507:511	a new antibacterial agent	487:511	a new antibacterial agent	487:511	In this work, ZIFs and chitosan (CS) were compounded by in-situ growth method to prepare a new antibacterial agent.
34273340	1	15	theme	new	159:161	arg1	materials					136:144	Zeolite imidazole framework materials	108:144	Zeolite imidazole framework materials (ZIFs)	108:151	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	1	15	theme	new	159:161	arg1	type					163:166	a new type	157:166	a new type of antibacterial material with high chemical and thermal stability	157:233	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	5	16	theme	long-term	984:992	arg1	properties					1026:1035	excellent long-term (at least 5 days) antibacterial properties	974:1035	excellent long-term (at least 5 days) antibacterial properties	974:1035	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	3	17	theme	antibacterial	493:505	arg1	agent					507:511	a new antibacterial agent	487:511	a new antibacterial agent	487:511	In this work, ZIFs and chitosan (CS) were compounded by in-situ growth method to prepare a new antibacterial agent.
34273340	3	18	theme	in-situ	454:460	arg1	method					469:474	in-situ growth method	454:474	in-situ growth method	454:474	In this work, ZIFs and chitosan (CS) were compounded by in-situ growth method to prepare a new antibacterial agent.
34273340	5	19	theme	cobalt	1054:1059	arg1	leaching					1042:1049	the leaching	1038:1049	the leaching of cobalt	1038:1059	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	0	20	from	materials	43:51	arg1	chitosan					56:63	chitosan	56:63	chitosan for greatly enhanced antibacterial effect	56:105	In situ growth zeolite imidazole framework materials on chitosan for greatly enhanced antibacterial effect.
34273340	0	21	theme	In	0:1	arg1	framework					33:41	In situ growth zeolite imidazole framework	0:41	In situ growth zeolite imidazole framework	0:41	In situ growth zeolite imidazole framework materials on chitosan for greatly enhanced antibacterial effect.
34273340	4	22	theme	inhibitory	744:753	arg1	rate					755:758	the inhibitory rate	740:758	the inhibitory rate of S. aureus	740:771	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	1	23	theme	antibacterial	171:183	arg1	material					185:192	antibacterial material	171:192	antibacterial material with high chemical and thermal stability	171:233	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	0	24	theme	zeolite	15:21	arg1	framework					33:41	In situ growth zeolite imidazole framework	0:41	In situ growth zeolite imidazole framework	0:41	In situ growth zeolite imidazole framework materials on chitosan for greatly enhanced antibacterial effect.
34273340	5	25	theme	internal	883:890	arg1	acid					900:903	internal nucleic acid	883:903	internal nucleic acid	883:903	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	4	26	theme	inhibitory	688:697	arg1	rate					699:702	its inhibitory rate	684:702	its inhibitory rate (in 15 h) of E. coli	684:723	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	1	27	theme	material	185:192	arg1	materials					136:144	Zeolite imidazole framework materials	108:144	Zeolite imidazole framework materials (ZIFs)	108:151	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	1	27	theme	material	185:192	arg1	type					163:166	a new type	157:166	a new type of antibacterial material with high chemical and thermal stability	157:233	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	1	27	theme	material	185:192	arg1	effect					259:264	good antibacterial effect	240:264	good antibacterial effect	240:264	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	0	28	theme	growth	8:13	arg1	framework					33:41	In situ growth zeolite imidazole framework	0:41	In situ growth zeolite imidazole framework	0:41	In situ growth zeolite imidazole framework materials on chitosan for greatly enhanced antibacterial effect.
34273340	4	29	theme	CS	531:532	arg1	synergism					518:526	The synergism	514:526	The synergism of CS and ZIFs	514:541	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	1	30	theme	Zeolite	108:114	arg1	materials					136:144	Zeolite imidazole framework materials	108:144	Zeolite imidazole framework materials (ZIFs)	108:151	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	1	30	theme	Zeolite	108:114	arg1	type					163:166	a new type	157:166	a new type of antibacterial material with high chemical and thermal stability	157:233	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	1	30	theme	Zeolite	108:114	arg1	ZIFs					147:150	ZIFs	147:150	ZIFs	147:150	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	2	31	theme	difficult	324:332	arg1	separation					334:343	difficult separation	324:343	difficult separation	324:343	However, powder ZIFs materials have the disadvantages of difficult separation and easy aggregation, which limit their application.
34273340	1	32	with	material	185:192	arg1	stability					225:233	high chemical and thermal stability	199:233	stability	225:233	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	1	32	with	material	185:192	arg1	chemical					204:211	chemical	204:211	chemical	204:211	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	5	33	theme	acid	900:903	arg1	leakage					872:878	leakage	872:878	leakage of internal nucleic acid and protein	872:915	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	5	33	theme	acid	900:903	arg1	rupture					860:866	bacterial cell membrane rupture	836:866	bacterial cell membrane rupture	836:866	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	4	34	theme	pristine	609:616	arg1	ZIFs					618:621	CS and pristine ZIFs	602:621	CS and pristine ZIFs	602:621	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	0	35	theme	imidazole	23:31	arg1	framework					33:41	In situ growth zeolite imidazole framework	0:41	In situ growth zeolite imidazole framework	0:41	In situ growth zeolite imidazole framework materials on chitosan for greatly enhanced antibacterial effect.
34273340	5	36	theme	antibacterial	1012:1024	arg1	properties					1026:1035	excellent long-term (at least 5 days) antibacterial properties	974:1035	excellent long-term (at least 5 days) antibacterial properties	974:1035	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	5	37	dep	long-term	984:992	arg1	5 days					1004:1009	5 days	1004:1009	5 days	1004:1009	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	5	38	theme	protein	909:915	arg1	leakage					872:878	leakage	872:878	leakage of internal nucleic acid and protein	872:915	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	5	38	theme	protein	909:915	arg1	rupture					860:866	bacterial cell membrane rupture	836:866	bacterial cell membrane rupture	836:866	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	2	39	theme	separation	334:343	arg1	disadvantages					307:319	the disadvantages	303:319	the disadvantages	303:319	However, powder ZIFs materials have the disadvantages of difficult separation and easy aggregation, which limit their application.
34273340	2	40	contain	have	298:301	arg1	materials					288:296	powder ZIFs materials	276:296	powder ZIFs materials	276:296	However, powder ZIFs materials have the disadvantages of difficult separation and easy aggregation, which limit their application.
34273340	2	40	contain	have	298:301	arg2	disadvantages					307:319	the disadvantages	303:319	the disadvantages	303:319	However, powder ZIFs materials have the disadvantages of difficult separation and easy aggregation, which limit their application.
34273340	1	41	theme	framework	126:134	arg1	materials					136:144	Zeolite imidazole framework materials	108:144	Zeolite imidazole framework materials (ZIFs)	108:151	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	1	41	theme	framework	126:134	arg1	type					163:166	a new type	157:166	a new type of antibacterial material with high chemical and thermal stability	157:233	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	1	41	theme	framework	126:134	arg1	ZIFs					147:150	ZIFs	147:150	ZIFs	147:150	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	5	42	theme	nucleic	892:898	arg1	acid					900:903	internal nucleic acid	883:903	internal nucleic acid	883:903	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	4	43	theme	best	651:654	arg1	activity					670:677	the best antibacterial activity	647:677	the best antibacterial activity	647:677	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	5	44	theme	excellent	974:982	arg1	properties					1026:1035	excellent long-term (at least 5 days) antibacterial properties	974:1035	excellent long-term (at least 5 days) antibacterial properties	974:1035	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	4	45	theme	antibacterial	567:579	arg1	effect					581:586	antibacterial effect	567:586	antibacterial effect	567:586	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	5	46	theme	cell	846:849	arg1	rupture					860:866	bacterial cell membrane rupture	836:866	bacterial cell membrane rupture	836:866	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	4	47	theme	antibacterial	656:668	arg1	activity					670:677	the best antibacterial activity	647:677	the best antibacterial activity	647:677	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	1	48	theme	thermal	217:223	arg1	stability					225:233	high chemical and thermal stability	199:233	stability	225:233	Zeolite imidazole framework materials (ZIFs) are a new type of antibacterial material with high chemical and thermal stability, and good antibacterial effect.
34273340	5	49	theme	antibacterial	935:947	arg1	effect					949:954	antibacterial effect	935:954	antibacterial effect	935:954	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	4	50	theme	coli	720:723	arg1	rate					699:702	its inhibitory rate	684:702	its inhibitory rate (in 15 h) of E. coli	684:723	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	4	51	theme	CS	602:603	arg1	ZIFs					618:621	CS and pristine ZIFs	602:621	CS and pristine ZIFs	602:621	The synergism of CS and ZIFs can effectively promote antibacterial effect compared with CS and pristine ZIFs, and CS/ZIF-67(1:6) has the best antibacterial activity, and its inhibitory rate (in 15 h) of E. coli is 96.75%, and the inhibitory rate of S. aureus reaches as high as 100%.
34273340	5	52	theme	bacterial	836:844	arg1	rupture					860:866	bacterial cell membrane rupture	836:866	bacterial cell membrane rupture	836:866	This composites can effectively cause bacterial cell membrane rupture and leakage of internal nucleic acid and protein, leads to achieve antibacterial effect, and also exhibit excellent long-term (at least 5 days) antibacterial properties, the leaching of cobalt is below than 0.5 mg·L-1, and this composites are with excellent bio-compatibility.
34273340	0	53	dep	In	0:1	arg1	situ					3:6	situ	3:6	situ	3:6	In situ growth zeolite imidazole framework materials on chitosan for greatly enhanced antibacterial effect.
34273340	2	54	theme	aggregation	354:364	arg1	disadvantages					307:319	the disadvantages	303:319	the disadvantages	303:319	However, powder ZIFs materials have the disadvantages of difficult separation and easy aggregation, which limit their application.
34273340	3	55	theme	growth	462:467	arg1	method					469:474	in-situ growth method	454:474	in-situ growth method	454:474	In this work, ZIFs and chitosan (CS) were compounded by in-situ growth method to prepare a new antibacterial agent.
34382780	0	0	theme	Honey	77:81	arg1	Composition					83:93	Trehalulose-Rich Honey Composition	60:93	Trehalulose-Rich Honey Composition	60:93	Feeding Sugars to Stingless Bees: Identifying the Origin of Trehalulose-Rich Honey Composition.
34382780	7	1	theme	fake	1041:1044	arg1	honey					1058:1062	The sucrose-fed fake and natural honey	1025:1062	The sucrose-fed fake and natural honey	1025:1062	The sucrose-fed fake and natural honey were however readily distinguished via isotope ratio mass spectrometry δ13C values, to combat such potential indirect adulteration.
34382780	6	2	theme	foraging	1011:1018	arg1	bee					1020:1022	the foraging bee	1007:1022	the foraging bee	1007:1022	Any temptation to artificially increase trehalulose content by feeding sucrose to stingless bees would produce "fake" honey lacking key natural phytochemicals available to the foraging bee.
34382780	0	3	theme	Trehalulose-Rich	60:75	arg1	Composition					83:93	Trehalulose-Rich Honey Composition	60:93	Trehalulose-Rich Honey Composition	60:93	Feeding Sugars to Stingless Bees: Identifying the Origin of Trehalulose-Rich Honey Composition.
34382780	6	4	dep	bees	927:930	arg1	to					914:915	to	914:915	to	914:915	Any temptation to artificially increase trehalulose content by feeding sucrose to stingless bees would produce "fake" honey lacking key natural phytochemicals available to the foraging bee.
34382780	5	5	theme	associated	801:810	arg1	properties					823:832	its associated beneficial properties	797:832	its associated beneficial properties	797:832	Hence, stingless bees with natural access to floral nectar high in sucrose will produce honey high in trehalulose, with its associated beneficial properties.
34382780	6	6	theme	stingless	917:925	arg1	bees					927:930	feeding sucrose to stingless bees	898:930	feeding sucrose to stingless bees	898:930	Any temptation to artificially increase trehalulose content by feeding sucrose to stingless bees would produce "fake" honey lacking key natural phytochemicals available to the foraging bee.
34382780	7	7	theme	spectrometry	1122:1133	arg1	values					1140:1145	isotope ratio mass spectrometry δ13C values	1103:1145	isotope ratio mass spectrometry δ13C values	1103:1145	The sucrose-fed fake and natural honey were however readily distinguished via isotope ratio mass spectrometry δ13C values, to combat such potential indirect adulteration.
34382780	3	8	theme	lesser	494:499	arg1	erlose					501:506	lesser erlose	494:506	lesser erlose (18-23%)	494:515	Complete conversion of fed sucrose was observed, by analysis of the honey, forming trehalulose (64-72%) with lesser erlose (18-23%), fructose (9-12%), and minor glucose detected.
34382780	3	8	theme	lesser	494:499	arg1	%					514:514	18-23%	509:514	18-23%	509:514	Complete conversion of fed sucrose was observed, by analysis of the honey, forming trehalulose (64-72%) with lesser erlose (18-23%), fructose (9-12%), and minor glucose detected.
34382780	4	9	theme	trehalulose/erlose	647:664	arg1	formation					666:674	trehalulose/erlose formation	647:674	trehalulose/erlose formation	647:674	Remarkably, feeding solutions of glucose/fructose (1:1) mixtures did not result in trehalulose/erlose formation.
34382780	0	10	theme	Composition	83:93	arg1	Origin					50:55	the Origin	46:55	the Origin of Trehalulose-Rich Honey Composition	46:93	Feeding Sugars to Stingless Bees: Identifying the Origin of Trehalulose-Rich Honey Composition.
34382780	7	11	theme	sucrose-fed	1029:1039	arg1	honey					1058:1062	The sucrose-fed fake and natural honey	1025:1062	The sucrose-fed fake and natural honey	1025:1062	The sucrose-fed fake and natural honey were however readily distinguished via isotope ratio mass spectrometry δ13C values, to combat such potential indirect adulteration.
34382780	7	12	theme	potential	1163:1171	arg1	adulteration					1182:1193	such potential indirect adulteration	1158:1193	such potential indirect adulteration	1158:1193	The sucrose-fed fake and natural honey were however readily distinguished via isotope ratio mass spectrometry δ13C values, to combat such potential indirect adulteration.
34382780	2	13	theme	confined	259:266	arg1	colonies					268:275	confined colonies	259:275	confined colonies of the Australian stingless bee Tetragonula carbonaria	259:330	By experimentally feeding sugar solutions to confined colonies of the Australian stingless bee Tetragonula carbonaria, the origin of trehalulose has now been established.
34382780	3	14	theme	honey	453:457	arg1	analysis					437:444	analysis	437:444	analysis of the honey	437:457	Complete conversion of fed sucrose was observed, by analysis of the honey, forming trehalulose (64-72%) with lesser erlose (18-23%), fructose (9-12%), and minor glucose detected.
34382780	7	15	theme	ratio	1111:1115	arg1	spectrometry					1122:1133	isotope ratio mass spectrometry	1103:1133	isotope ratio mass spectrometry δ13C values	1103:1145	The sucrose-fed fake and natural honey were however readily distinguished via isotope ratio mass spectrometry δ13C values, to combat such potential indirect adulteration.
34382780	5	16	theme	beneficial	812:821	arg1	properties					823:832	its associated beneficial properties	797:832	its associated beneficial properties	797:832	Hence, stingless bees with natural access to floral nectar high in sucrose will produce honey high in trehalulose, with its associated beneficial properties.
34382780	5	17	with	bees	694:697	arg1	access					712:717	natural access	704:717	natural access to floral nectar high in sucrose	704:750	Hence, stingless bees with natural access to floral nectar high in sucrose will produce honey high in trehalulose, with its associated beneficial properties.
34382780	3	18	theme	fed	408:410	arg1	sucrose					412:418	fed sucrose	408:418	fed sucrose	408:418	Complete conversion of fed sucrose was observed, by analysis of the honey, forming trehalulose (64-72%) with lesser erlose (18-23%), fructose (9-12%), and minor glucose detected.
34382780	1	19	theme	stingless	154:162	arg1	bee					164:166	stingless bee honey	154:172	stingless bee honey	154:172	The beneficial disaccharide, trehalulose, is a feature of stingless bee honey, while not dominant in any other foods.
34382780	6	20	theme	sucrose	906:912	arg1	bees					927:930	feeding sucrose to stingless bees	898:930	feeding sucrose to stingless bees	898:930	Any temptation to artificially increase trehalulose content by feeding sucrose to stingless bees would produce "fake" honey lacking key natural phytochemicals available to the foraging bee.
34382780	1	21	theme	bee	164:166	arg1	disaccharide					111:122	The beneficial disaccharide	96:122	The beneficial disaccharide	96:122	The beneficial disaccharide, trehalulose, is a feature of stingless bee honey, while not dominant in any other foods.
34382780	1	21	theme	bee	164:166	arg1	feature					143:149	a feature	141:149	a feature of stingless bee honey	141:172	The beneficial disaccharide, trehalulose, is a feature of stingless bee honey, while not dominant in any other foods.
34382780	5	22	theme	stingless	684:692	arg1	bees					694:697	stingless bees	684:697	stingless bees with natural access to floral nectar high in sucrose	684:750	Hence, stingless bees with natural access to floral nectar high in sucrose will produce honey high in trehalulose, with its associated beneficial properties.
34382780	2	23	theme	stingless	295:303	arg1	carbonaria					321:330	the Australian stingless bee Tetragonula carbonaria	280:330	the Australian stingless bee Tetragonula carbonaria	280:330	By experimentally feeding sugar solutions to confined colonies of the Australian stingless bee Tetragonula carbonaria, the origin of trehalulose has now been established.
34382780	5	24	from	high	736:739	arg1	sucrose					744:750	sucrose	744:750	sucrose	744:750	Hence, stingless bees with natural access to floral nectar high in sucrose will produce honey high in trehalulose, with its associated beneficial properties.
34382780	1	25	theme	honey	168:172	arg1	bee					164:166	stingless bee honey	154:172	stingless bee honey	154:172	The beneficial disaccharide, trehalulose, is a feature of stingless bee honey, while not dominant in any other foods.
34382780	7	26	theme	isotope	1103:1109	arg1	spectrometry					1122:1133	isotope ratio mass spectrometry	1103:1133	isotope ratio mass spectrometry δ13C values	1103:1145	The sucrose-fed fake and natural honey were however readily distinguished via isotope ratio mass spectrometry δ13C values, to combat such potential indirect adulteration.
34382780	6	27	theme	feeding	898:904	arg1	bees					927:930	feeding sucrose to stingless bees	898:930	feeding sucrose to stingless bees	898:930	Any temptation to artificially increase trehalulose content by feeding sucrose to stingless bees would produce "fake" honey lacking key natural phytochemicals available to the foraging bee.
34382780	2	28	theme	Australian	284:293	arg1	carbonaria					321:330	the Australian stingless bee Tetragonula carbonaria	280:330	the Australian stingless bee Tetragonula carbonaria	280:330	By experimentally feeding sugar solutions to confined colonies of the Australian stingless bee Tetragonula carbonaria, the origin of trehalulose has now been established.
34382780	3	29	theme	sucrose	412:418	arg1	conversion					394:403	Complete conversion	385:403	Complete conversion of fed sucrose	385:418	Complete conversion of fed sucrose was observed, by analysis of the honey, forming trehalulose (64-72%) with lesser erlose (18-23%), fructose (9-12%), and minor glucose detected.
34382780	0	30	theme	Stingless	18:26	arg1	Bees					28:31	Stingless Bees	18:31	Stingless Bees	18:31	Feeding Sugars to Stingless Bees: Identifying the Origin of Trehalulose-Rich Honey Composition.
34382780	6	31	theme	key	967:969	arg1	phytochemicals					979:992	key natural phytochemicals	967:992	key natural phytochemicals available to the foraging bee	967:1022	Any temptation to artificially increase trehalulose content by feeding sucrose to stingless bees would produce "fake" honey lacking key natural phytochemicals available to the foraging bee.
34382780	1	32	theme	beneficial	100:109	arg1	trehalulose					125:135	trehalulose	125:135	trehalulose	125:135	The beneficial disaccharide, trehalulose, is a feature of stingless bee honey, while not dominant in any other foods.
34382780	1	32	theme	beneficial	100:109	arg1	disaccharide					111:122	The beneficial disaccharide	96:122	The beneficial disaccharide	96:122	The beneficial disaccharide, trehalulose, is a feature of stingless bee honey, while not dominant in any other foods.
34382780	1	32	theme	beneficial	100:109	arg1	feature					143:149	a feature	141:149	a feature of stingless bee honey	141:172	The beneficial disaccharide, trehalulose, is a feature of stingless bee honey, while not dominant in any other foods.
34382780	4	33	theme	glucose/fructose	597:612	arg1	mixtures					620:627	glucose/fructose (1:1) mixtures	597:627	glucose/fructose (1:1) mixtures	597:627	Remarkably, feeding solutions of glucose/fructose (1:1) mixtures did not result in trehalulose/erlose formation.
34382780	6	34	theme	trehalulose	875:885	arg1	content					887:893	trehalulose content	875:893	trehalulose content	875:893	Any temptation to artificially increase trehalulose content by feeding sucrose to stingless bees would produce "fake" honey lacking key natural phytochemicals available to the foraging bee.
34382780	7	35	theme	indirect	1173:1180	arg1	adulteration					1182:1193	such potential indirect adulteration	1158:1193	such potential indirect adulteration	1158:1193	The sucrose-fed fake and natural honey were however readily distinguished via isotope ratio mass spectrometry δ13C values, to combat such potential indirect adulteration.
34382780	4	36	theme	feeding	576:582	arg1	solutions					584:592	feeding solutions	576:592	feeding solutions of glucose/fructose (1:1) mixtures	576:627	Remarkably, feeding solutions of glucose/fructose (1:1) mixtures did not result in trehalulose/erlose formation.
34382780	3	37	theme	minor	540:544	arg1	glucose					546:552	minor glucose	540:552	minor glucose detected	540:561	Complete conversion of fed sucrose was observed, by analysis of the honey, forming trehalulose (64-72%) with lesser erlose (18-23%), fructose (9-12%), and minor glucose detected.
34382780	1	38	from	dominant	185:192	arg1	foods					207:211	any other foods	197:211	any other foods	197:211	The beneficial disaccharide, trehalulose, is a feature of stingless bee honey, while not dominant in any other foods.
34382780	6	39	theme	"	951:951	arg1	honey					953:957	"fake" honey	946:957	"fake" honey lacking key natural phytochemicals available to the foraging bee	946:1022	Any temptation to artificially increase trehalulose content by feeding sucrose to stingless bees would produce "fake" honey lacking key natural phytochemicals available to the foraging bee.
34382780	5	40	theme	natural	704:710	arg1	access					712:717	natural access	704:717	natural access to floral nectar high in sucrose	704:750	Hence, stingless bees with natural access to floral nectar high in sucrose will produce honey high in trehalulose, with its associated beneficial properties.
34382780	1	41	from	foods	207:211	arg1	dominant					185:192	dominant	185:192	dominant	185:192	The beneficial disaccharide, trehalulose, is a feature of stingless bee honey, while not dominant in any other foods.
34382780	4	42	theme	mixtures	620:627	arg1	solutions					584:592	feeding solutions	576:592	feeding solutions of glucose/fructose (1:1) mixtures	576:627	Remarkably, feeding solutions of glucose/fructose (1:1) mixtures did not result in trehalulose/erlose formation.
34382780	3	43	theme	Complete	385:392	arg1	conversion					394:403	Complete conversion	385:403	Complete conversion of fed sucrose	385:418	Complete conversion of fed sucrose was observed, by analysis of the honey, forming trehalulose (64-72%) with lesser erlose (18-23%), fructose (9-12%), and minor glucose detected.
34382780	7	44	theme	mass	1117:1120	arg1	spectrometry					1122:1133	isotope ratio mass spectrometry	1103:1133	isotope ratio mass spectrometry δ13C values	1103:1145	The sucrose-fed fake and natural honey were however readily distinguished via isotope ratio mass spectrometry δ13C values, to combat such potential indirect adulteration.
34382780	2	45	theme	carbonaria	321:330	arg1	colonies					268:275	confined colonies	259:275	confined colonies of the Australian stingless bee Tetragonula carbonaria	259:330	By experimentally feeding sugar solutions to confined colonies of the Australian stingless bee Tetragonula carbonaria, the origin of trehalulose has now been established.
34382780	2	46	theme	sugar	240:244	arg1	solutions					246:254	sugar solutions	240:254	sugar solutions	240:254	By experimentally feeding sugar solutions to confined colonies of the Australian stingless bee Tetragonula carbonaria, the origin of trehalulose has now been established.
34382780	5	47	from	sucrose	744:750	arg1	high					736:739	high	736:739	high	736:739	Hence, stingless bees with natural access to floral nectar high in sucrose will produce honey high in trehalulose, with its associated beneficial properties.
34382780	2	48	theme	Tetragonula	309:319	arg1	carbonaria					321:330	the Australian stingless bee Tetragonula carbonaria	280:330	the Australian stingless bee Tetragonula carbonaria	280:330	By experimentally feeding sugar solutions to confined colonies of the Australian stingless bee Tetragonula carbonaria, the origin of trehalulose has now been established.
34382780	6	49	theme	fake	947:950	arg1	honey					953:957	"fake" honey	946:957	"fake" honey lacking key natural phytochemicals available to the foraging bee	946:1022	Any temptation to artificially increase trehalulose content by feeding sucrose to stingless bees would produce "fake" honey lacking key natural phytochemicals available to the foraging bee.
34382780	6	50	theme	natural	971:977	arg1	phytochemicals					979:992	key natural phytochemicals	967:992	key natural phytochemicals available to the foraging bee	967:1022	Any temptation to artificially increase trehalulose content by feeding sucrose to stingless bees would produce "fake" honey lacking key natural phytochemicals available to the foraging bee.
34382780	2	51	theme	bee	305:307	arg1	carbonaria					321:330	the Australian stingless bee Tetragonula carbonaria	280:330	the Australian stingless bee Tetragonula carbonaria	280:330	By experimentally feeding sugar solutions to confined colonies of the Australian stingless bee Tetragonula carbonaria, the origin of trehalulose has now been established.
34382780	1	52	theme	other	201:205	arg1	foods					207:211	any other foods	197:211	any other foods	197:211	The beneficial disaccharide, trehalulose, is a feature of stingless bee honey, while not dominant in any other foods.
34382780	2	53	theme	trehalulose	347:357	arg1	origin					337:342	the origin	333:342	the origin of trehalulose	333:357	By experimentally feeding sugar solutions to confined colonies of the Australian stingless bee Tetragonula carbonaria, the origin of trehalulose has now been established.
34382780	6	54	theme	available	994:1002	arg1	phytochemicals					979:992	key natural phytochemicals	967:992	key natural phytochemicals available to the foraging bee	967:1022	Any temptation to artificially increase trehalulose content by feeding sucrose to stingless bees would produce "fake" honey lacking key natural phytochemicals available to the foraging bee.
34382780	7	55	theme	natural	1050:1056	arg1	honey					1058:1062	The sucrose-fed fake and natural honey	1025:1062	The sucrose-fed fake and natural honey	1025:1062	The sucrose-fed fake and natural honey were however readily distinguished via isotope ratio mass spectrometry δ13C values, to combat such potential indirect adulteration.
34382780	1	56	dep	not	181:183	arg1	dominant					185:192	dominant	185:192	dominant	185:192	The beneficial disaccharide, trehalulose, is a feature of stingless bee honey, while not dominant in any other foods.
34382780	7	57	theme	such	1158:1161	arg1	adulteration					1182:1193	such potential indirect adulteration	1158:1193	such potential indirect adulteration	1158:1193	The sucrose-fed fake and natural honey were however readily distinguished via isotope ratio mass spectrometry δ13C values, to combat such potential indirect adulteration.
34382780	7	58	theme	δ13C	1135:1138	arg1	values					1140:1145	isotope ratio mass spectrometry δ13C values	1103:1145	isotope ratio mass spectrometry δ13C values	1103:1145	The sucrose-fed fake and natural honey were however readily distinguished via isotope ratio mass spectrometry δ13C values, to combat such potential indirect adulteration.
34351297	6	0	theme	toluene	993:999	arg1	adsorption					967:976	the adsorption	963:976	the adsorption of benzene and toluene	963:999	Kinetic analysis showed that the adsorption of benzene and toluene follows a pseudo-second order model, while the experimental adsorption data were well-fitted by the Freundlich isotherm.
34351297	2	1	theme	siliceous	360:368	arg1	materials					370:378	siliceous materials	360:378	siliceous materials	360:378	As an alternative, hydrogels prepared from polymers functionalized with siliceous materials can overcome this issue.
34351297	9	2	from	water	1584:1588	arg1	removal					1551:1557	the removal	1547:1557	the removal of these pollutants from water	1547:1588	Although hydrogels are not common adsorbents for aromatic hydrocarbons, the results reported here rank GEL-SBA15 as a promising adsorbent for the removal of these pollutants from water.
34351297	0	3	theme	composite	64:72	arg1	hydrogel					74:81	a composite hydrogel	62:81	a composite hydrogel of alginate-grafted with mesoporous silica	62:124	Adsorption of benzene and toluene from aqueous solution using a composite hydrogel of alginate-grafted with mesoporous silica.
34351297	0	4	with	hydrogel	74:81	arg1	silica					119:124	mesoporous silica	108:124	mesoporous silica	108:124	Adsorption of benzene and toluene from aqueous solution using a composite hydrogel of alginate-grafted with mesoporous silica.
34351297	1	5	theme	optimal	158:164	arg1	Hydrogels					127:135	Hydrogels	127:135	Hydrogels	127:135	Hydrogels are often claimed as optimal adsorbents for water treatment; however, their efficiency towards the removal of hydrophobic pollutants is still limited.
34351297	1	5	theme	optimal	158:164	arg1	adsorbents					166:175	optimal adsorbents	158:175	optimal adsorbents for water treatment	158:195	Hydrogels are often claimed as optimal adsorbents for water treatment; however, their efficiency towards the removal of hydrophobic pollutants is still limited.
34351297	1	6	theme	hydrophobic	247:257	arg1	pollutants					259:268	hydrophobic pollutants	247:268	hydrophobic pollutants	247:268	Hydrogels are often claimed as optimal adsorbents for water treatment; however, their efficiency towards the removal of hydrophobic pollutants is still limited.
34351297	0	7	theme	alginate-grafted	86:101	arg1	hydrogel					74:81	a composite hydrogel	62:81	a composite hydrogel of alginate-grafted with mesoporous silica	62:124	Adsorption of benzene and toluene from aqueous solution using a composite hydrogel of alginate-grafted with mesoporous silica.
34351297	4	8	from	25 °C	805:809	arg1	pH					794:795	pH 7.0	794:799	pH 7.0	794:799	Adsorption studies demonstrated that a low dosage of GEL-SBA15 (10 mg) has a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g) under mild experimental conditions (pH 7.0, at 25 °C).
34351297	7	9	theme	der	1249:1251	arg1	Waals					1253:1257	van der Waals	1245:1257	van der Waals	1245:1257	According to this isotherm, the adsorption occurs via a collaborative process, and weak physical forces (π-π interactions, van der Waals and hydrophobic) are involved.
34351297	4	10	theme	low	644:646	arg1	dosage					648:653	a low dosage	642:653	a low dosage of GEL-SBA15 (10 mg)	642:674	Adsorption studies demonstrated that a low dosage of GEL-SBA15 (10 mg) has a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g) under mild experimental conditions (pH 7.0, at 25 °C).
34351297	1	11	theme	pollutants	259:268	arg1	removal					236:242	the removal	232:242	the removal of hydrophobic pollutants	232:268	Hydrogels are often claimed as optimal adsorbents for water treatment; however, their efficiency towards the removal of hydrophobic pollutants is still limited.
34351297	0	12	from	solution	47:54	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of benzene and toluene from aqueous solution using a composite hydrogel of alginate-grafted with mesoporous silica.	0:125	Adsorption of benzene and toluene from aqueous solution using a composite hydrogel of alginate-grafted with mesoporous silica.
34351297	7	13	dep	forces	1219:1224	arg1	interactions					1231:1242	π-π interactions	1227:1242	π-π interactions	1227:1242	According to this isotherm, the adsorption occurs via a collaborative process, and weak physical forces (π-π interactions, van der Waals and hydrophobic) are involved.
34351297	3	14	theme	mesoporous	496:505	arg1	silica					507:512	mesoporous silica	496:512	mesoporous silica (SBA15)	496:520	Here, a composite hydrogel (denoted as GEL-SBA15) was prepared using alginate grafted with mesoporous silica (SBA15) and poly(vinyl alcohol) for benzene and toluene adsorption from aqueous solutions.
34351297	3	14	theme	mesoporous	496:505	arg1	SBA15					515:519	SBA15	515:519	SBA15	515:519	Here, a composite hydrogel (denoted as GEL-SBA15) was prepared using alginate grafted with mesoporous silica (SBA15) and poly(vinyl alcohol) for benzene and toluene adsorption from aqueous solutions.
34351297	6	15	theme	adsorption	1061:1070	arg1	data					1072:1075	the experimental adsorption data	1044:1075	the experimental adsorption data	1044:1075	Kinetic analysis showed that the adsorption of benzene and toluene follows a pseudo-second order model, while the experimental adsorption data were well-fitted by the Freundlich isotherm.
34351297	0	16	theme	mesoporous	108:117	arg1	silica					119:124	mesoporous silica	108:124	mesoporous silica	108:124	Adsorption of benzene and toluene from aqueous solution using a composite hydrogel of alginate-grafted with mesoporous silica.
34351297	4	17	dep	conditions	782:791	arg1	pH					794:795	pH 7.0	794:799	pH 7.0	794:799	Adsorption studies demonstrated that a low dosage of GEL-SBA15 (10 mg) has a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g) under mild experimental conditions (pH 7.0, at 25 °C).
34351297	5	18	theme	conventional	911:922	arg1	hydrogel					924:931	the conventional hydrogel	907:931	the conventional hydrogel	907:931	Besides, the adsorption capacities of GEL-SBA15 for both pollutants were enhanced compared to the conventional hydrogel.
34351297	6	19	theme	pseudo-second	1011:1023	arg1	model					1031:1035	a pseudo-second order model	1009:1035	a pseudo-second order model	1009:1035	Kinetic analysis showed that the adsorption of benzene and toluene follows a pseudo-second order model, while the experimental adsorption data were well-fitted by the Freundlich isotherm.
34351297	3	20	dep	benzene	550:556	arg1	adsorption					570:579	adsorption	570:579	adsorption	570:579	Here, a composite hydrogel (denoted as GEL-SBA15) was prepared using alginate grafted with mesoporous silica (SBA15) and poly(vinyl alcohol) for benzene and toluene adsorption from aqueous solutions.
34351297	4	21	contain	has	676:678	arg2	capacity					698:705	a high adsorption capacity	680:705	a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g)	680:756	Adsorption studies demonstrated that a low dosage of GEL-SBA15 (10 mg) has a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g) under mild experimental conditions (pH 7.0, at 25 °C).
34351297	4	21	contain	has	676:678	arg1	dosage					648:653	a low dosage	642:653	a low dosage of GEL-SBA15 (10 mg)	642:674	Adsorption studies demonstrated that a low dosage of GEL-SBA15 (10 mg) has a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g) under mild experimental conditions (pH 7.0, at 25 °C).
34351297	5	22	theme	adsorption	826:835	arg1	capacities					837:846	the adsorption capacities	822:846	the adsorption capacities of GEL-SBA15 for both pollutants	822:879	Besides, the adsorption capacities of GEL-SBA15 for both pollutants were enhanced compared to the conventional hydrogel.
34351297	3	23	from	solutions	594:602	arg1	poly					526:529	poly	526:529	poly(vinyl alcohol) for benzene and toluene adsorption from aqueous solutions	526:602	Here, a composite hydrogel (denoted as GEL-SBA15) was prepared using alginate grafted with mesoporous silica (SBA15) and poly(vinyl alcohol) for benzene and toluene adsorption from aqueous solutions.
34351297	3	23	from	solutions	594:602	arg1	alcohol					537:543	vinyl alcohol	531:543	vinyl alcohol	531:543	Here, a composite hydrogel (denoted as GEL-SBA15) was prepared using alginate grafted with mesoporous silica (SBA15) and poly(vinyl alcohol) for benzene and toluene adsorption from aqueous solutions.
34351297	3	23	from	solutions	594:602	arg1	alginate					474:481	alginate	474:481	alginate grafted with mesoporous silica (SBA15)	474:520	Here, a composite hydrogel (denoted as GEL-SBA15) was prepared using alginate grafted with mesoporous silica (SBA15) and poly(vinyl alcohol) for benzene and toluene adsorption from aqueous solutions.
34351297	6	24	theme	order	1025:1029	arg1	model					1031:1035	a pseudo-second order model	1009:1035	a pseudo-second order model	1009:1035	Kinetic analysis showed that the adsorption of benzene and toluene follows a pseudo-second order model, while the experimental adsorption data were well-fitted by the Freundlich isotherm.
34351297	9	25	theme	rank	1503:1506	arg1	GEL-SBA15					1508:1516	rank GEL-SBA15	1503:1516	rank GEL-SBA15	1503:1516	Although hydrogels are not common adsorbents for aromatic hydrocarbons, the results reported here rank GEL-SBA15 as a promising adsorbent for the removal of these pollutants from water.
34351297	9	25	theme	rank	1503:1506	arg1	adsorbent					1533:1541	adsorbent	1533:1541	adsorbent	1533:1541	Although hydrogels are not common adsorbents for aromatic hydrocarbons, the results reported here rank GEL-SBA15 as a promising adsorbent for the removal of these pollutants from water.
34351297	1	26	theme	water	181:185	arg1	treatment					187:195	water treatment	181:195	water treatment	181:195	Hydrogels are often claimed as optimal adsorbents for water treatment; however, their efficiency towards the removal of hydrophobic pollutants is still limited.
34351297	6	27	theme	Freundlich	1101:1110	arg1	isotherm					1112:1119	the Freundlich isotherm	1097:1119	the Freundlich isotherm	1097:1119	Kinetic analysis showed that the adsorption of benzene and toluene follows a pseudo-second order model, while the experimental adsorption data were well-fitted by the Freundlich isotherm.
34351297	9	28	theme	aromatic	1454:1461	arg1	hydrocarbons					1463:1474	aromatic hydrocarbons	1454:1474	aromatic hydrocarbons	1454:1474	Although hydrogels are not common adsorbents for aromatic hydrocarbons, the results reported here rank GEL-SBA15 as a promising adsorbent for the removal of these pollutants from water.
34351297	3	29	theme	vinyl	531:535	arg1	poly					526:529	poly	526:529	poly(vinyl alcohol) for benzene and toluene adsorption from aqueous solutions	526:602	Here, a composite hydrogel (denoted as GEL-SBA15) was prepared using alginate grafted with mesoporous silica (SBA15) and poly(vinyl alcohol) for benzene and toluene adsorption from aqueous solutions.
34351297	3	29	theme	vinyl	531:535	arg1	alcohol					537:543	vinyl alcohol	531:543	vinyl alcohol	531:543	Here, a composite hydrogel (denoted as GEL-SBA15) was prepared using alginate grafted with mesoporous silica (SBA15) and poly(vinyl alcohol) for benzene and toluene adsorption from aqueous solutions.
34351297	4	30	theme	experimental	769:780	arg1	conditions					782:791	mild experimental conditions	764:791	mild experimental conditions (pH 7.0, at 25 °C)	764:810	Adsorption studies demonstrated that a low dosage of GEL-SBA15 (10 mg) has a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g) under mild experimental conditions (pH 7.0, at 25 °C).
34351297	7	31	theme	van	1245:1247	arg1	Waals					1253:1257	van der Waals	1245:1257	van der Waals	1245:1257	According to this isotherm, the adsorption occurs via a collaborative process, and weak physical forces (π-π interactions, van der Waals and hydrophobic) are involved.
34351297	0	32	theme	benzene	14:20	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of benzene and toluene from aqueous solution using a composite hydrogel of alginate-grafted with mesoporous silica.	0:125	Adsorption of benzene and toluene from aqueous solution using a composite hydrogel of alginate-grafted with mesoporous silica.
34351297	9	33	theme	common	1432:1437	arg1	adsorbents					1439:1448	common adsorbents	1432:1448	common adsorbents for aromatic hydrocarbons	1432:1474	Although hydrogels are not common adsorbents for aromatic hydrocarbons, the results reported here rank GEL-SBA15 as a promising adsorbent for the removal of these pollutants from water.
34351297	9	33	theme	common	1432:1437	arg1	hydrogels					1414:1422	hydrogels	1414:1422	hydrogels	1414:1422	Although hydrogels are not common adsorbents for aromatic hydrocarbons, the results reported here rank GEL-SBA15 as a promising adsorbent for the removal of these pollutants from water.
34351297	8	34	theme	post-utilized	1301:1313	arg1	GEL-SBA15					1315:1323	the post-utilized GEL-SBA15	1297:1323	the post-utilized GEL-SBA15	1297:1323	Hence, the post-utilized GEL-SBA15 can be recycled and reused up to 6 times without losing adsorption performance.
34351297	4	35	theme	Adsorption	605:614	arg1	studies					616:622	Adsorption studies	605:622	Adsorption studies	605:622	Adsorption studies demonstrated that a low dosage of GEL-SBA15 (10 mg) has a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g) under mild experimental conditions (pH 7.0, at 25 °C).
34351297	3	36	dep	hydrogel	423:430	arg1	denoted					433:439	denoted	433:439	denoted as GEL-SBA15	433:452	Here, a composite hydrogel (denoted as GEL-SBA15) was prepared using alginate grafted with mesoporous silica (SBA15) and poly(vinyl alcohol) for benzene and toluene adsorption from aqueous solutions.
34351297	0	37	theme	toluene	26:32	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of benzene and toluene from aqueous solution using a composite hydrogel of alginate-grafted with mesoporous silica.	0:125	Adsorption of benzene and toluene from aqueous solution using a composite hydrogel of alginate-grafted with mesoporous silica.
34351297	3	38	theme	composite	413:421	arg1	hydrogel					423:430	a composite hydrogel	411:430	a composite hydrogel (denoted as GEL-SBA15)	411:453	Here, a composite hydrogel (denoted as GEL-SBA15) was prepared using alginate grafted with mesoporous silica (SBA15) and poly(vinyl alcohol) for benzene and toluene adsorption from aqueous solutions.
34351297	8	39	theme	adsorption	1381:1390	arg1	performance					1392:1402	adsorption performance	1381:1402	adsorption performance	1381:1402	Hence, the post-utilized GEL-SBA15 can be recycled and reused up to 6 times without losing adsorption performance.
34351297	4	40	theme	mild	764:767	arg1	conditions					782:791	mild experimental conditions	764:791	mild experimental conditions (pH 7.0, at 25 °C)	764:810	Adsorption studies demonstrated that a low dosage of GEL-SBA15 (10 mg) has a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g) under mild experimental conditions (pH 7.0, at 25 °C).
34351297	6	41	theme	benzene	981:987	arg1	adsorption					967:976	the adsorption	963:976	the adsorption of benzene and toluene	963:999	Kinetic analysis showed that the adsorption of benzene and toluene follows a pseudo-second order model, while the experimental adsorption data were well-fitted by the Freundlich isotherm.
34351297	7	42	theme	collaborative	1178:1190	arg1	process					1192:1198	a collaborative process	1176:1198	a collaborative process	1176:1198	According to this isotherm, the adsorption occurs via a collaborative process, and weak physical forces (π-π interactions, van der Waals and hydrophobic) are involved.
34351297	8	43	dep	6	1358:1358	arg1	to					1355:1356	to	1355:1356	to	1355:1356	Hence, the post-utilized GEL-SBA15 can be recycled and reused up to 6 times without losing adsorption performance.
34351297	0	44	theme	aqueous	39:45	arg1	solution					47:54	aqueous solution	39:54	aqueous solution using a composite hydrogel of alginate-grafted with mesoporous silica	39:124	Adsorption of benzene and toluene from aqueous solution using a composite hydrogel of alginate-grafted with mesoporous silica.
34351297	5	45	theme	GEL-SBA15	851:859	arg1	capacities					837:846	the adsorption capacities	822:846	the adsorption capacities of GEL-SBA15 for both pollutants	822:879	Besides, the adsorption capacities of GEL-SBA15 for both pollutants were enhanced compared to the conventional hydrogel.
34351297	7	46	theme	weak	1205:1208	arg1	forces					1219:1224	weak physical forces	1205:1224	weak physical forces (π-π interactions, van der Waals and hydrophobic)	1205:1274	According to this isotherm, the adsorption occurs via a collaborative process, and weak physical forces (π-π interactions, van der Waals and hydrophobic) are involved.
34351297	7	47	dep	interactions	1231:1242	arg1	hydrophobic					1263:1273	hydrophobic	1263:1273	hydrophobic	1263:1273	According to this isotherm, the adsorption occurs via a collaborative process, and weak physical forces (π-π interactions, van der Waals and hydrophobic) are involved.
34351297	7	47	dep	interactions	1231:1242	arg1	Waals					1253:1257	van der Waals	1245:1257	van der Waals	1245:1257	According to this isotherm, the adsorption occurs via a collaborative process, and weak physical forces (π-π interactions, van der Waals and hydrophobic) are involved.
34351297	9	48	theme	pollutants	1568:1577	arg1	removal					1551:1557	the removal	1547:1557	the removal of these pollutants from water	1547:1588	Although hydrogels are not common adsorbents for aromatic hydrocarbons, the results reported here rank GEL-SBA15 as a promising adsorbent for the removal of these pollutants from water.
34351297	4	49	theme	adsorption	687:696	arg1	capacity					698:705	a high adsorption capacity	680:705	a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g)	680:756	Adsorption studies demonstrated that a low dosage of GEL-SBA15 (10 mg) has a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g) under mild experimental conditions (pH 7.0, at 25 °C).
34351297	4	50	theme	high	682:685	arg1	capacity					698:705	a high adsorption capacity	680:705	a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g)	680:756	Adsorption studies demonstrated that a low dosage of GEL-SBA15 (10 mg) has a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g) under mild experimental conditions (pH 7.0, at 25 °C).
34351297	7	51	theme	physical	1210:1217	arg1	forces					1219:1224	weak physical forces	1205:1224	weak physical forces (π-π interactions, van der Waals and hydrophobic)	1205:1274	According to this isotherm, the adsorption occurs via a collaborative process, and weak physical forces (π-π interactions, van der Waals and hydrophobic) are involved.
34351297	6	52	theme	experimental	1048:1059	arg1	data					1072:1075	the experimental adsorption data	1044:1075	the experimental adsorption data	1044:1075	Kinetic analysis showed that the adsorption of benzene and toluene follows a pseudo-second order model, while the experimental adsorption data were well-fitted by the Freundlich isotherm.
34351297	6	53	theme	Kinetic	934:940	arg1	analysis					942:949	Kinetic analysis	934:949	Kinetic analysis	934:949	Kinetic analysis showed that the adsorption of benzene and toluene follows a pseudo-second order model, while the experimental adsorption data were well-fitted by the Freundlich isotherm.
34351297	3	54	theme	aqueous	586:592	arg1	solutions					594:602	aqueous solutions	586:602	aqueous solutions	586:602	Here, a composite hydrogel (denoted as GEL-SBA15) was prepared using alginate grafted with mesoporous silica (SBA15) and poly(vinyl alcohol) for benzene and toluene adsorption from aqueous solutions.
34351297	4	55	theme	GEL-SBA15	658:666	arg1	dosage					648:653	a low dosage	642:653	a low dosage of GEL-SBA15 (10 mg)	642:674	Adsorption studies demonstrated that a low dosage of GEL-SBA15 (10 mg) has a high adsorption capacity for benzene (1482.8 mg/g) and toluene (596.6 mg/g) under mild experimental conditions (pH 7.0, at 25 °C).
33399115	1	0	theme	method	273:278	arg1	use					248:250	the use	244:250	the use of the freeze-drying method	244:278	Scaffolds based on chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures cross-linked by tannic acid (TA) with bioglass 45S5 addition were obtained with the use of the freeze-drying method.
33399115	6	1	theme	scaffold	875:882	arg1	structure					884:892	a porous scaffold structure	866:892	a porous scaffold structure	866:892	Scanning electron microscope images allowed the observation of a porous scaffold structure with interconnected pores.
33399115	6	2	theme	porous	868:873	arg1	structure					884:892	a porous scaffold structure	866:892	a porous scaffold structure	866:892	Scanning electron microscope images allowed the observation of a porous scaffold structure with interconnected pores.
33399115	2	3	theme	prepared	285:292	arg1	scaffolds					294:302	The prepared scaffolds	281:302	The prepared scaffolds	281:302	The prepared scaffolds were characterised for morphology, mechanical strength and degradation rate.
33399115	7	4	theme	bioglass	937:944	arg1	nanoparticles					946:958	bioglass nanoparticles	937:958	bioglass nanoparticles	937:958	The addition of bioglass nanoparticles improved the mechanical properties and decreased the degradation rate of composite materials.
33399115	3	5	theme	acid	487:490	arg1	presence					466:473	the presence	462:473	the presence of ascorbic acid and dexamethasone	462:508	Moreover, cell viability on the obtained scaffolds was measured with and without the presence of ascorbic acid and dexamethasone.
33399115	1	6	theme	bioglass	202:209	arg1	addition					216:223	bioglass 45S5 addition	202:223	bioglass 45S5 addition	202:223	Scaffolds based on chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures cross-linked by tannic acid (TA) with bioglass 45S5 addition were obtained with the use of the freeze-drying method.
33399115	5	7	from	stable	769:774	arg1	environment					790:800	an aqueous environment	779:800	an aqueous environment	779:800	The results demonstrated that the scaffolds based on the blends of biopolymers cross-linked by TA are stable in an aqueous environment.
33399115	1	8	theme	45S5	211:214	arg1	addition					216:223	bioglass 45S5 addition	202:223	bioglass 45S5 addition	202:223	Scaffolds based on chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures cross-linked by tannic acid (TA) with bioglass 45S5 addition were obtained with the use of the freeze-drying method.
33399115	5	9	theme	aqueous	782:788	arg1	environment					790:800	an aqueous environment	779:800	an aqueous environment	779:800	The results demonstrated that the scaffolds based on the blends of biopolymers cross-linked by TA are stable in an aqueous environment.
33399115	3	10	theme	obtained	413:420	arg1	scaffolds					422:430	the obtained scaffolds	409:430	the obtained scaffolds	409:430	Moreover, cell viability on the obtained scaffolds was measured with and without the presence of ascorbic acid and dexamethasone.
33399115	2	11	theme	mechanical	339:348	arg1	strength					350:357	mechanical strength	339:357	mechanical strength	339:357	The prepared scaffolds were characterised for morphology, mechanical strength and degradation rate.
33399115	9	12	theme	45S5	1173:1176	arg1	addition					1152:1159	the addition	1148:1159	the addition of bioglass 45S5	1148:1176	However, the addition of bioglass 45S5 did not change to cells response significantly.
33399115	3	13	theme	ascorbic	478:485	arg1	acid					487:490	ascorbic acid	478:490	ascorbic acid	478:490	Moreover, cell viability on the obtained scaffolds was measured with and without the presence of ascorbic acid and dexamethasone.
33399115	1	14	theme	glycosaminoglycans	130:147	arg1	mixtures					155:162	chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures	94:162	chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures cross-linked by tannic acid (TA) with bioglass 45S5 addition	94:223	Scaffolds based on chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures cross-linked by tannic acid (TA) with bioglass 45S5 addition were obtained with the use of the freeze-drying method.
33399115	8	15	theme	biological	1058:1067	arg1	properties					1069:1078	The biological properties	1054:1078	The biological properties	1054:1078	The biological properties were improved for 20% tannic acid addition compared to 5%.
33399115	4	16	theme	influence	594:602	arg1	effectiveness					563:575	the effectiveness	559:575	the effectiveness of bioglass 45S5 influence on the physicochemical and biological properties of scaffolds	559:664	The main purpose of the research was to compare the effectiveness of bioglass 45S5 influence on the physicochemical and biological properties of scaffolds.
33399115	7	17	theme	composite	1033:1041	arg1	materials					1043:1051	composite materials	1033:1051	composite materials	1033:1051	The addition of bioglass nanoparticles improved the mechanical properties and decreased the degradation rate of composite materials.
33399115	4	18	theme	physicochemical	611:625	arg1	properties					642:651	the physicochemical and biological properties	607:651	the physicochemical and biological properties of scaffolds	607:664	The main purpose of the research was to compare the effectiveness of bioglass 45S5 influence on the physicochemical and biological properties of scaffolds.
33399115	9	19	theme	cells	1196:1200	arg1	response					1202:1209	cells response	1196:1209	cells response	1196:1209	However, the addition of bioglass 45S5 did not change to cells response significantly.
33399115	9	20	theme	bioglass	1164:1171	arg1	45S5					1173:1176	bioglass 45S5	1164:1176	bioglass 45S5	1164:1176	However, the addition of bioglass 45S5 did not change to cells response significantly.
33399115	3	21	theme	dexamethasone	496:508	arg1	presence					466:473	the presence	462:473	the presence of ascorbic acid and dexamethasone	462:508	Moreover, cell viability on the obtained scaffolds was measured with and without the presence of ascorbic acid and dexamethasone.
33399115	8	22	dep	improved	1085:1092	arg1	compared					1123:1130	compared	1123:1130	compared to 5%	1123:1136	The biological properties were improved for 20% tannic acid addition compared to 5%.
33399115	0	23	theme	scaffolds	14:22	arg1	Properties					0:9	Properties	0:9	Properties of scaffolds	0:22	Properties of scaffolds based on chitosan and collagen with bioglass 45S5.
33399115	4	24	theme	main	515:518	arg1	purpose					520:526	The main purpose	511:526	The main purpose of the research	511:542	The main purpose of the research was to compare the effectiveness of bioglass 45S5 influence on the physicochemical and biological properties of scaffolds.
33399115	1	25	theme	chitosan	94:101	arg1	mixtures					155:162	chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures	94:162	chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures cross-linked by tannic acid (TA) with bioglass 45S5 addition	94:223	Scaffolds based on chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures cross-linked by tannic acid (TA) with bioglass 45S5 addition were obtained with the use of the freeze-drying method.
33399115	2	26	theme	degradation	363:373	arg1	rate					375:378	degradation rate	363:378	degradation rate	363:378	The prepared scaffolds were characterised for morphology, mechanical strength and degradation rate.
33399115	7	27	theme	materials	1043:1051	arg1	rate					1025:1028	the degradation rate	1009:1028	the degradation rate of composite materials	1009:1051	The addition of bioglass nanoparticles improved the mechanical properties and decreased the degradation rate of composite materials.
33399115	6	28	theme	microscope	821:830	arg1	images					832:837	Scanning electron microscope images	803:837	Scanning electron microscope images	803:837	Scanning electron microscope images allowed the observation of a porous scaffold structure with interconnected pores.
33399115	6	29	with	observation	851:861	arg1	pores					914:918	interconnected pores	899:918	interconnected pores	899:918	Scanning electron microscope images allowed the observation of a porous scaffold structure with interconnected pores.
33399115	4	30	from	effectiveness	563:575	arg1	properties					642:651	the physicochemical and biological properties	607:651	the physicochemical and biological properties of scaffolds	607:664	The main purpose of the research was to compare the effectiveness of bioglass 45S5 influence on the physicochemical and biological properties of scaffolds.
33399115	4	31	theme	45S5	589:592	arg1	influence					594:602	bioglass 45S5 influence	580:602	bioglass 45S5 influence	580:602	The main purpose of the research was to compare the effectiveness of bioglass 45S5 influence on the physicochemical and biological properties of scaffolds.
33399115	4	32	theme	biological	631:640	arg1	properties					642:651	the physicochemical and biological properties	607:651	the physicochemical and biological properties of scaffolds	607:664	The main purpose of the research was to compare the effectiveness of bioglass 45S5 influence on the physicochemical and biological properties of scaffolds.
33399115	5	33	theme	biopolymers	734:744	arg1	blends					724:729	the blends	720:729	the blends of biopolymers cross-linked by TA	720:763	The results demonstrated that the scaffolds based on the blends of biopolymers cross-linked by TA are stable in an aqueous environment.
33399115	6	34	theme	electron	812:819	arg1	images					832:837	Scanning electron microscope images	803:837	Scanning electron microscope images	803:837	Scanning electron microscope images allowed the observation of a porous scaffold structure with interconnected pores.
33399115	3	35	from	viability	396:404	arg1	scaffolds					422:430	the obtained scaffolds	409:430	the obtained scaffolds	409:430	Moreover, cell viability on the obtained scaffolds was measured with and without the presence of ascorbic acid and dexamethasone.
33399115	4	36	theme	bioglass	580:587	arg1	influence					594:602	bioglass 45S5 influence	580:602	bioglass 45S5 influence	580:602	The main purpose of the research was to compare the effectiveness of bioglass 45S5 influence on the physicochemical and biological properties of scaffolds.
33399115	6	37	theme	Scanning	803:810	arg1	images					832:837	Scanning electron microscope images	803:837	Scanning electron microscope images	803:837	Scanning electron microscope images allowed the observation of a porous scaffold structure with interconnected pores.
33399115	8	38	theme	acid	1109:1112	arg1	addition					1114:1121	tannic acid addition	1102:1121	tannic acid addition	1102:1121	The biological properties were improved for 20% tannic acid addition compared to 5%.
33399115	6	39	theme	interconnected	899:912	arg1	pores					914:918	interconnected pores	899:918	interconnected pores	899:918	Scanning electron microscope images allowed the observation of a porous scaffold structure with interconnected pores.
33399115	6	40	theme	structure	884:892	arg1	observation					851:861	the observation	847:861	the observation of a porous scaffold structure with interconnected pores	847:918	Scanning electron microscope images allowed the observation of a porous scaffold structure with interconnected pores.
33399115	4	41	theme	scaffolds	656:664	arg1	properties					642:651	the physicochemical and biological properties	607:651	the physicochemical and biological properties of scaffolds	607:664	The main purpose of the research was to compare the effectiveness of bioglass 45S5 influence on the physicochemical and biological properties of scaffolds.
33399115	7	42	theme	degradation	1013:1023	arg1	rate					1025:1028	the degradation rate	1009:1028	the degradation rate of composite materials	1009:1051	The addition of bioglass nanoparticles improved the mechanical properties and decreased the degradation rate of composite materials.
33399115	7	43	theme	nanoparticles	946:958	arg1	addition					925:932	The addition	921:932	The addition of bioglass nanoparticles	921:958	The addition of bioglass nanoparticles improved the mechanical properties and decreased the degradation rate of composite materials.
33399115	1	44	theme	tannic	180:185	arg1	TA					193:194	TA	193:194	TA	193:194	Scaffolds based on chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures cross-linked by tannic acid (TA) with bioglass 45S5 addition were obtained with the use of the freeze-drying method.
33399115	1	44	theme	tannic	180:185	arg1	acid					187:190	tannic acid	180:190	tannic acid (TA)	180:195	Scaffolds based on chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures cross-linked by tannic acid (TA) with bioglass 45S5 addition were obtained with the use of the freeze-drying method.
33399115	8	45	theme	tannic	1102:1107	arg1	addition					1114:1121	tannic acid addition	1102:1121	tannic acid addition	1102:1121	The biological properties were improved for 20% tannic acid addition compared to 5%.
33399115	5	46	from	environment	790:800	arg1	scaffolds					701:709	the scaffolds	697:709	the scaffolds based on the blends of biopolymers cross-linked by TA	697:763	The results demonstrated that the scaffolds based on the blends of biopolymers cross-linked by TA are stable in an aqueous environment.
33399115	5	46	from	environment	790:800	arg1	stable					769:774	stable	769:774	stable	769:774	The results demonstrated that the scaffolds based on the blends of biopolymers cross-linked by TA are stable in an aqueous environment.
33399115	0	47	with	collagen	46:53	arg1	45S5					69:72	bioglass 45S5	60:72	bioglass 45S5	60:72	Properties of scaffolds based on chitosan and collagen with bioglass 45S5.
33399115	0	48	theme	bioglass	60:67	arg1	45S5					69:72	bioglass 45S5	60:72	bioglass 45S5	60:72	Properties of scaffolds based on chitosan and collagen with bioglass 45S5.
33399115	7	49	theme	mechanical	973:982	arg1	properties					984:993	the mechanical properties	969:993	the mechanical properties	969:993	The addition of bioglass nanoparticles improved the mechanical properties and decreased the degradation rate of composite materials.
33399115	1	50	theme	collagen	110:117	arg1	mixtures					155:162	chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures	94:162	chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures cross-linked by tannic acid (TA) with bioglass 45S5 addition	94:223	Scaffolds based on chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures cross-linked by tannic acid (TA) with bioglass 45S5 addition were obtained with the use of the freeze-drying method.
33399115	3	51	theme	cell	391:394	arg1	viability					396:404	cell viability	391:404	cell viability on the obtained scaffolds	391:430	Moreover, cell viability on the obtained scaffolds was measured with and without the presence of ascorbic acid and dexamethasone.
33399115	4	52	theme	research	535:542	arg1	purpose					520:526	The main purpose	511:526	The main purpose of the research	511:542	The main purpose of the research was to compare the effectiveness of bioglass 45S5 influence on the physicochemical and biological properties of scaffolds.
33399115	1	53	theme	freeze-drying	259:271	arg1	method					273:278	the freeze-drying method	255:278	the freeze-drying method	255:278	Scaffolds based on chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures cross-linked by tannic acid (TA) with bioglass 45S5 addition were obtained with the use of the freeze-drying method.
33399115	0	54	with	chitosan	33:40	arg1	45S5					69:72	bioglass 45S5	60:72	bioglass 45S5	60:72	Properties of scaffolds based on chitosan and collagen with bioglass 45S5.
32877714	3	0	theme	treated	533:539	arg1	fiber					550:554	chemically treated 5% MgCO3 fiber	522:554	chemically treated 5% MgCO3 fiber	522:554	The mechanical test result shows that chemically treated 5% MgCO3 fiber show that 4% and 24% improved tensile strength compared to NaOH and untreated ones.
32877714	7	1	theme	%	1240:1240	arg1	tensile					1200:1206	tensile	1200:1206	tensile	1200:1206	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	7	1	theme	%	1240:1240	arg1	modulus					1191:1197	Young's modulus	1183:1197	Young's modulus	1183:1197	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	7	1	theme	%	1240:1240	arg1	strength					1222:1229	flexural strength	1213:1229	flexural strength of 8%, 27%, and 16%	1213:1249	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	6	2	theme	orthogonal	1053:1062	arg1	approach					1070:1077	L9 Taguchi orthogonal array approach	1042:1077	L9 Taguchi orthogonal array approach	1042:1077	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	7	3	theme	flexural	1213:1220	arg1	modulus					1191:1197	Young's modulus	1183:1197	Young's modulus	1183:1197	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	7	3	theme	flexural	1213:1220	arg1	strength					1222:1229	flexural strength	1213:1229	flexural strength of 8%, 27%, and 16%	1213:1249	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	8	4	theme	untreated	1371:1379	arg1	fiber					1395:1399	both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber	1340:1399	both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber	1340:1399	Moreover, there was no notable improvement observed on impact strength for both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber.
32877714	2	5	theme	Cissus	322:327	arg1	fibers					344:349	the Cissus quadrangularis fibers	318:349	the Cissus quadrangularis fibers	318:349	Initially, the Cissus quadrangularis fibers were chemically treated with 5% Sodium hydroxide (NaOH) and 5% magnesium carbonate (MgCO3) to improvise the properties of the fiber.
32877714	5	6	theme	present	851:857	arg1	lignin					822:827	lignin	822:827	lignin	822:827	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	6	theme	present	851:857	arg1	amount					787:792	a larger amount	778:792	a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface	778:878	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	6	theme	present	851:857	arg1	hemicellulose					807:819	amorphous hemicellulose	797:819	amorphous hemicellulose	797:819	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	6	theme	present	851:857	arg1	impurities					840:849	other impurities	834:849	other impurities	834:849	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	9	7	theme	electron	1415:1422	arg1	SEM					1436:1438	SEM	1436:1438	SEM	1436:1438	The scanning electron microscopy (SEM) micrographs used to examine the interface bonding between fiber and the matrix.
32877714	9	7	theme	electron	1415:1422	arg1	microscopy					1424:1433	scanning electron microscopy	1406:1433	The scanning electron microscopy (SEM) micrographs	1402:1451	The scanning electron microscopy (SEM) micrographs used to examine the interface bonding between fiber and the matrix.
32877714	6	8	with	combination	935:945	arg1	approach					1070:1077	L9 Taguchi orthogonal array approach	1042:1077	L9 Taguchi orthogonal array approach	1042:1077	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	0	9	theme	composites	129:138	arg1	properties					68:77	properties	68:77	properties of natural cellulosic Cissus quadrangularis fiber composites	68:138	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.
32877714	5	10	theme	hemicellulose	807:819	arg1	lignin					822:827	lignin	822:827	lignin	822:827	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	10	theme	hemicellulose	807:819	arg1	amount					787:792	a larger amount	778:792	a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface	778:878	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	10	theme	hemicellulose	807:819	arg1	hemicellulose					807:819	amorphous hemicellulose	797:819	amorphous hemicellulose	797:819	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	10	theme	hemicellulose	807:819	arg1	impurities					840:849	other impurities	834:849	other impurities	834:849	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	1	11	theme	reinforcing	262:272	arg1	materials					274:282	reinforcing materials	262:282	reinforcing materials in polymer composites	262:304	Cissus quadrangularis biodegradable natural cellulosic fibers comprehensively characterized to assess their potential as reinforcing materials in polymer composites.
32877714	6	12	theme	different	925:933	arg1	combination					935:945	different combination	925:945	different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach	925:1077	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	7	13	theme	significant	1156:1166	arg1	improvement					1168:1178	significant improvement	1156:1178	significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16%	1156:1249	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	6	14	theme	L9	1042:1043	arg1	approach					1070:1077	L9 Taguchi orthogonal array approach	1042:1077	L9 Taguchi orthogonal array approach	1042:1077	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	1	15	theme	quadrangularis	148:161	arg1	fibers					196:201	Cissus quadrangularis biodegradable natural cellulosic fibers	141:201	Cissus quadrangularis biodegradable natural cellulosic fibers	141:201	Cissus quadrangularis biodegradable natural cellulosic fibers comprehensively characterized to assess their potential as reinforcing materials in polymer composites.
32877714	7	16	theme	%	1134:1134	arg1	volume					1142:1147	30% fiber volume	1132:1147	30% fiber volume	1132:1147	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	4	17	theme	fiber	683:687	arg1	got					689:691	the treated fiber got	671:691	the treated fiber got	671:691	The cellulose crystallinity of the treated fiber got increased as the amorphous constituents removed.
32877714	5	18	theme	%	752:752	arg1	treatment					760:768	5% MgCO3 treatment	751:768	5% MgCO3 treatment	751:768	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	8	19	dep	untreated	1371:1379	arg1	KJ/m2					1388:1392	13.98 KJ/m2	1382:1392	13.98 KJ/m2	1382:1392	Moreover, there was no notable improvement observed on impact strength for both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber.
32877714	1	20	theme	natural	177:183	arg1	fibers					196:201	Cissus quadrangularis biodegradable natural cellulosic fibers	141:201	Cissus quadrangularis biodegradable natural cellulosic fibers	141:201	Cissus quadrangularis biodegradable natural cellulosic fibers comprehensively characterized to assess their potential as reinforcing materials in polymer composites.
32877714	9	21	theme	interface	1473:1481	arg1	bonding					1483:1489	the interface bonding	1469:1489	the interface bonding between fiber and the matrix	1469:1518	The scanning electron microscopy (SEM) micrographs used to examine the interface bonding between fiber and the matrix.
32877714	0	22	from	Effects	0:6	arg1	properties					68:77	properties	68:77	properties of natural cellulosic Cissus quadrangularis fiber composites	68:138	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.
32877714	6	23	dep	plasticizer	972:982	arg1	%					997:997	10%	995:997	10%	995:997	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	6	23	dep	plasticizer	972:982	arg1	%					986:986	5%	985:986	5%	985:986	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	6	23	dep	plasticizer	972:982	arg1	%					992:992	7.5%	989:992	7.5%	989:992	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	0	24	theme	cellulosic	90:99	arg1	composites					129:138	natural cellulosic Cissus quadrangularis fiber composites	82:138	natural cellulosic Cissus quadrangularis fiber composites	82:138	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.
32877714	0	25	theme	quadrangularis	108:121	arg1	composites					129:138	natural cellulosic Cissus quadrangularis fiber composites	82:138	natural cellulosic Cissus quadrangularis fiber composites	82:138	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.
32877714	8	26	dep	treated	1345:1351	arg1	KJ/m2					1360:1364	15.91 KJ/m2	1354:1364	15.91 KJ/m2	1354:1364	Moreover, there was no notable improvement observed on impact strength for both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber.
32877714	7	27	theme	30	1132:1133	arg1	%					1134:1134	%	1134:1134	%	1134:1134	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	2	28	theme	magnesium	414:422	arg1	carbonate					424:432	5% magnesium carbonate	411:432	5% magnesium carbonate (MgCO3)	411:440	Initially, the Cissus quadrangularis fibers were chemically treated with 5% Sodium hydroxide (NaOH) and 5% magnesium carbonate (MgCO3) to improvise the properties of the fiber.
32877714	2	28	theme	magnesium	414:422	arg1	MgCO3					435:439	MgCO3	435:439	MgCO3	435:439	Initially, the Cissus quadrangularis fibers were chemically treated with 5% Sodium hydroxide (NaOH) and 5% magnesium carbonate (MgCO3) to improvise the properties of the fiber.
32877714	5	29	theme	amorphous	797:805	arg1	hemicellulose					807:819	amorphous hemicellulose	797:819	amorphous hemicellulose	797:819	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	0	30	theme	magnesium	11:19	arg1	concentration					31:43	magnesium carbonate concentration	11:43	magnesium carbonate concentration	11:43	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.
32877714	3	31	theme	MgCO3	544:548	arg1	fiber					550:554	chemically treated 5% MgCO3 fiber	522:554	chemically treated 5% MgCO3 fiber	522:554	The mechanical test result shows that chemically treated 5% MgCO3 fiber show that 4% and 24% improved tensile strength compared to NaOH and untreated ones.
32877714	5	32	attach	present	851:857	arg2	lignin					822:827	lignin	822:827	lignin	822:827	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	32	attach	present	851:857	arg2	hemicellulose					807:819	amorphous hemicellulose	797:819	amorphous hemicellulose	797:819	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	32	attach	present	851:857	arg2	amount					787:792	a larger amount	778:792	a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface	778:878	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	32	attach	present	851:857	arg1	surface					872:878	the fiber surface	862:878	the fiber surface	862:878	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	32	attach	present	851:857	arg2	impurities					840:849	other impurities	834:849	other impurities	834:849	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	7	33	theme	%	1113:1113	arg1	plasticizer					1115:1125	5% plasticizer	1112:1125	5% plasticizer	1112:1125	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	0	34	theme	concentration	31:43	arg1	Effects					0:6	Effects	0:6	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.	0:139	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.
32877714	0	35	theme	lignin	49:54	arg1	presence					56:63	lignin presence	49:63	lignin presence	49:63	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.
32877714	7	36	theme	%	1103:1103	arg1	MgCO3					1105:1109	5% MgCO3	1102:1109	5% MgCO3	1102:1109	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	3	37	theme	test	499:502	arg1	result					504:509	The mechanical test result	484:509	The mechanical test result	484:509	The mechanical test result shows that chemically treated 5% MgCO3 fiber show that 4% and 24% improved tensile strength compared to NaOH and untreated ones.
32877714	6	38	dep	volume	1011:1016	arg1	%					1021:1021	20%	1019:1021	20%	1019:1021	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	6	38	dep	volume	1011:1016	arg1	%					1026:1026	25%	1024:1026	25%	1024:1026	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	6	38	dep	volume	1011:1016	arg1	%					1034:1034	30%	1032:1034	30%	1032:1034	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	3	39	theme	5	541:541	arg1	%					542:542	%	542:542	%	542:542	The mechanical test result shows that chemically treated 5% MgCO3 fiber show that 4% and 24% improved tensile strength compared to NaOH and untreated ones.
32877714	1	40	theme	polymer	287:293	arg1	composites					295:304	polymer composites	287:304	polymer composites	287:304	Cissus quadrangularis biodegradable natural cellulosic fibers comprehensively characterized to assess their potential as reinforcing materials in polymer composites.
32877714	5	41	theme	larger	780:785	arg1	lignin					822:827	lignin	822:827	lignin	822:827	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	41	theme	larger	780:785	arg1	amount					787:792	a larger amount	778:792	a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface	778:878	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	41	theme	larger	780:785	arg1	hemicellulose					807:819	amorphous hemicellulose	797:819	amorphous hemicellulose	797:819	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	41	theme	larger	780:785	arg1	impurities					840:849	other impurities	834:849	other impurities	834:849	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	42	theme	MgCO3	754:758	arg1	treatment					760:768	5% MgCO3 treatment	751:768	5% MgCO3 treatment	751:768	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	7	43	theme	%	1235:1235	arg1	tensile					1200:1206	tensile	1200:1206	tensile	1200:1206	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	7	43	theme	%	1235:1235	arg1	modulus					1191:1197	Young's modulus	1183:1197	Young's modulus	1183:1197	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	7	43	theme	%	1235:1235	arg1	strength					1222:1229	flexural strength	1213:1229	flexural strength of 8%, 27%, and 16%	1213:1249	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	6	44	theme	volume	1011:1016	arg1	combination					935:945	different combination	925:945	different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach	925:1077	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	2	45	theme	quadrangularis	329:342	arg1	fibers					344:349	the Cissus quadrangularis fibers	318:349	the Cissus quadrangularis fibers	318:349	Initially, the Cissus quadrangularis fibers were chemically treated with 5% Sodium hydroxide (NaOH) and 5% magnesium carbonate (MgCO3) to improvise the properties of the fiber.
32877714	5	46	theme	impurities	840:849	arg1	lignin					822:827	lignin	822:827	lignin	822:827	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	46	theme	impurities	840:849	arg1	amount					787:792	a larger amount	778:792	a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface	778:878	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	46	theme	impurities	840:849	arg1	hemicellulose					807:819	amorphous hemicellulose	797:819	amorphous hemicellulose	797:819	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	46	theme	impurities	840:849	arg1	impurities					840:849	other impurities	834:849	other impurities	834:849	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	4	47	theme	cellulose	644:652	arg1	crystallinity					654:666	The cellulose crystallinity	640:666	The cellulose crystallinity of the treated fiber got	640:691	The cellulose crystallinity of the treated fiber got increased as the amorphous constituents removed.
32877714	2	48	theme	5	380:380	arg1	%					381:381	%	381:381	%	381:381	Initially, the Cissus quadrangularis fibers were chemically treated with 5% Sodium hydroxide (NaOH) and 5% magnesium carbonate (MgCO3) to improvise the properties of the fiber.
32877714	9	49	theme	scanning	1406:1413	arg1	SEM					1436:1438	SEM	1436:1438	SEM	1436:1438	The scanning electron microscopy (SEM) micrographs used to examine the interface bonding between fiber and the matrix.
32877714	9	49	theme	scanning	1406:1413	arg1	microscopy					1424:1433	scanning electron microscopy	1406:1433	The scanning electron microscopy (SEM) micrographs	1402:1451	The scanning electron microscopy (SEM) micrographs used to examine the interface bonding between fiber and the matrix.
32877714	5	50	theme	lignin	822:827	arg1	lignin					822:827	lignin	822:827	lignin	822:827	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	50	theme	lignin	822:827	arg1	amount					787:792	a larger amount	778:792	a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface	778:878	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	50	theme	lignin	822:827	arg1	hemicellulose					807:819	amorphous hemicellulose	797:819	amorphous hemicellulose	797:819	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	50	theme	lignin	822:827	arg1	impurities					840:849	other impurities	834:849	other impurities	834:849	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	6	51	theme	MgCO3	950:954	arg1	combination					935:945	different combination	925:945	different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach	925:1077	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	2	52	theme	5	411:411	arg1	%					412:412	%	412:412	%	412:412	Initially, the Cissus quadrangularis fibers were chemically treated with 5% Sodium hydroxide (NaOH) and 5% magnesium carbonate (MgCO3) to improvise the properties of the fiber.
32877714	1	53	theme	biodegradable	163:175	arg1	fibers					196:201	Cissus quadrangularis biodegradable natural cellulosic fibers	141:201	Cissus quadrangularis biodegradable natural cellulosic fibers	141:201	Cissus quadrangularis biodegradable natural cellulosic fibers comprehensively characterized to assess their potential as reinforcing materials in polymer composites.
32877714	6	54	theme	fiber	1005:1009	arg1	volume					1011:1016	fiber volume	1005:1016	fiber volume (20%, 25% and 30%)	1005:1035	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	3	55	theme	tensile	586:592	arg1	strength					594:601	tensile strength	586:601	tensile strength	586:601	The mechanical test result shows that chemically treated 5% MgCO3 fiber show that 4% and 24% improved tensile strength compared to NaOH and untreated ones.
32877714	7	56	theme	Young	1183:1187	arg1	tensile					1200:1206	tensile	1200:1206	tensile	1200:1206	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	7	56	theme	Young	1183:1187	arg1	modulus					1191:1197	Young's modulus	1183:1197	Young's modulus	1183:1197	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	7	56	theme	Young	1183:1187	arg1	strength					1222:1229	flexural strength	1213:1229	flexural strength of 8%, 27%, and 16%	1213:1249	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	6	57	dep	MgCO3	950:954	arg1	%					958:958	5%	957:958	5%	957:958	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	6	57	dep	MgCO3	950:954	arg1	%					963:963	10%	961:963	10%	961:963	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	6	57	dep	MgCO3	950:954	arg1	%					968:968	15%	966:968	15%	966:968	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	6	58	theme	Taguchi	1045:1051	arg1	approach					1070:1077	L9 Taguchi orthogonal array approach	1042:1077	L9 Taguchi orthogonal array approach	1042:1077	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	1	59	from	materials	274:282	arg1	composites					295:304	polymer composites	287:304	polymer composites	287:304	Cissus quadrangularis biodegradable natural cellulosic fibers comprehensively characterized to assess their potential as reinforcing materials in polymer composites.
32877714	1	60	theme	Cissus	141:146	arg1	fibers					196:201	Cissus quadrangularis biodegradable natural cellulosic fibers	141:201	Cissus quadrangularis biodegradable natural cellulosic fibers	141:201	Cissus quadrangularis biodegradable natural cellulosic fibers comprehensively characterized to assess their potential as reinforcing materials in polymer composites.
32877714	8	61	located	observed	1308:1315	arg1	strength					1327:1334	impact strength	1320:1334	impact strength	1320:1334	Moreover, there was no notable improvement observed on impact strength for both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber.
32877714	8	61	located	observed	1308:1315	arg2	improvement					1296:1306	no notable improvement	1285:1306	no notable improvement observed on impact strength for both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber	1285:1399	Moreover, there was no notable improvement observed on impact strength for both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber.
32877714	4	62	theme	amorphous	710:718	arg1	constituents					720:731	the amorphous constituents	706:731	the amorphous constituents removed	706:739	The cellulose crystallinity of the treated fiber got increased as the amorphous constituents removed.
32877714	2	63	theme	Sodium	383:388	arg1	hydroxide					390:398	5% Sodium hydroxide	380:398	5% Sodium hydroxide (NaOH)	380:405	Initially, the Cissus quadrangularis fibers were chemically treated with 5% Sodium hydroxide (NaOH) and 5% magnesium carbonate (MgCO3) to improvise the properties of the fiber.
32877714	2	63	theme	Sodium	383:388	arg1	NaOH					401:404	NaOH	401:404	NaOH	401:404	Initially, the Cissus quadrangularis fibers were chemically treated with 5% Sodium hydroxide (NaOH) and 5% magnesium carbonate (MgCO3) to improvise the properties of the fiber.
32877714	5	64	theme	5	751:751	arg1	%					752:752	%	752:752	%	752:752	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	5	65	theme	fiber	866:870	arg1	surface					872:878	the fiber surface	862:878	the fiber surface	862:878	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	7	66	theme	fiber	1136:1140	arg1	volume					1142:1147	30% fiber volume	1132:1147	30% fiber volume	1132:1147	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	4	67	theme	treated	675:681	arg1	got					689:691	the treated fiber got	671:691	the treated fiber got	671:691	The cellulose crystallinity of the treated fiber got increased as the amorphous constituents removed.
32877714	0	68	theme	natural	82:88	arg1	composites					129:138	natural cellulosic Cissus quadrangularis fiber composites	82:138	natural cellulosic Cissus quadrangularis fiber composites	82:138	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.
32877714	1	69	theme	cellulosic	185:194	arg1	fibers					196:201	Cissus quadrangularis biodegradable natural cellulosic fibers	141:201	Cissus quadrangularis biodegradable natural cellulosic fibers	141:201	Cissus quadrangularis biodegradable natural cellulosic fibers comprehensively characterized to assess their potential as reinforcing materials in polymer composites.
32877714	9	70	theme	microscopy	1424:1433	arg1	micrographs					1441:1451	The scanning electron microscopy (SEM) micrographs	1402:1451	The scanning electron microscopy (SEM) micrographs	1402:1451	The scanning electron microscopy (SEM) micrographs used to examine the interface bonding between fiber and the matrix.
32877714	4	71	theme	got	689:691	arg1	crystallinity					654:666	The cellulose crystallinity	640:666	The cellulose crystallinity of the treated fiber got	640:691	The cellulose crystallinity of the treated fiber got increased as the amorphous constituents removed.
32877714	0	72	theme	Cissus	101:106	arg1	composites					129:138	natural cellulosic Cissus quadrangularis fiber composites	82:138	natural cellulosic Cissus quadrangularis fiber composites	82:138	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.
32877714	0	73	theme	fiber	123:127	arg1	composites					129:138	natural cellulosic Cissus quadrangularis fiber composites	82:138	natural cellulosic Cissus quadrangularis fiber composites	82:138	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.
32877714	8	74	theme	notable	1288:1294	arg1	improvement					1296:1306	no notable improvement	1285:1306	no notable improvement observed on impact strength for both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber	1285:1399	Moreover, there was no notable improvement observed on impact strength for both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber.
32877714	2	75	theme	%	412:412	arg1	carbonate					424:432	5% magnesium carbonate	411:432	5% magnesium carbonate (MgCO3)	411:440	Initially, the Cissus quadrangularis fibers were chemically treated with 5% Sodium hydroxide (NaOH) and 5% magnesium carbonate (MgCO3) to improvise the properties of the fiber.
32877714	2	75	theme	%	412:412	arg1	MgCO3					435:439	MgCO3	435:439	MgCO3	435:439	Initially, the Cissus quadrangularis fibers were chemically treated with 5% Sodium hydroxide (NaOH) and 5% magnesium carbonate (MgCO3) to improvise the properties of the fiber.
32877714	0	76	theme	carbonate	21:29	arg1	concentration					31:43	magnesium carbonate concentration	11:43	magnesium carbonate concentration	11:43	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.
32877714	7	77	theme	5	1112:1112	arg1	%					1113:1113	%	1113:1113	%	1113:1113	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	3	78	theme	mechanical	488:497	arg1	result					504:509	The mechanical test result	484:509	The mechanical test result	484:509	The mechanical test result shows that chemically treated 5% MgCO3 fiber show that 4% and 24% improved tensile strength compared to NaOH and untreated ones.
32877714	9	79	used	used	1453:1456	arg2	micrographs					1441:1451	The scanning electron microscopy (SEM) micrographs	1402:1451	The scanning electron microscopy (SEM) micrographs	1402:1451	The scanning electron microscopy (SEM) micrographs used to examine the interface bonding between fiber and the matrix.
32877714	6	80	theme	plasticizer	972:982	arg1	combination					935:945	different combination	925:945	different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach	925:1077	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	8	81	theme	impact	1320:1325	arg1	strength					1327:1334	impact strength	1320:1334	impact strength	1320:1334	Moreover, there was no notable improvement observed on impact strength for both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber.
32877714	3	82	theme	untreated	624:632	arg1	ones					634:637	untreated ones	624:637	untreated ones	624:637	The mechanical test result shows that chemically treated 5% MgCO3 fiber show that 4% and 24% improved tensile strength compared to NaOH and untreated ones.
32877714	5	83	theme	other	834:838	arg1	impurities					840:849	other impurities	834:849	other impurities	834:849	Further, 5% MgCO3 treatment removed a larger amount of amorphous hemicellulose, lignin, and other impurities present on the fiber surface.
32877714	0	84	theme	presence	56:63	arg1	Effects					0:6	Effects	0:6	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.	0:139	Effects of magnesium carbonate concentration and lignin presence on properties of natural cellulosic Cissus quadrangularis fiber composites.
32877714	7	85	theme	5	1102:1102	arg1	%					1103:1103	%	1103:1103	%	1103:1103	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	2	86	theme	fiber	477:481	arg1	properties					459:468	the properties	455:468	the properties of the fiber	455:481	Initially, the Cissus quadrangularis fibers were chemically treated with 5% Sodium hydroxide (NaOH) and 5% magnesium carbonate (MgCO3) to improvise the properties of the fiber.
32877714	6	87	theme	array	1064:1068	arg1	approach					1070:1077	L9 Taguchi orthogonal array approach	1042:1077	L9 Taguchi orthogonal array approach	1042:1077	Secondly, the composites were fabricated at different combination of MgCO3 (5%, 10%, 15%), plasticizer (5%, 7.5%, 10%), and fiber volume (20%, 25% and 30%) with L9 Taguchi orthogonal array approach.
32877714	8	88	theme	treated	1345:1351	arg1	fiber					1395:1399	both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber	1340:1399	both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber	1340:1399	Moreover, there was no notable improvement observed on impact strength for both treated (15.91 KJ/m2) and untreated (13.98 KJ/m2) fiber.
32877714	2	89	theme	%	381:381	arg1	hydroxide					390:398	5% Sodium hydroxide	380:398	5% Sodium hydroxide (NaOH)	380:405	Initially, the Cissus quadrangularis fibers were chemically treated with 5% Sodium hydroxide (NaOH) and 5% magnesium carbonate (MgCO3) to improvise the properties of the fiber.
32877714	2	89	theme	%	381:381	arg1	NaOH					401:404	NaOH	401:404	NaOH	401:404	Initially, the Cissus quadrangularis fibers were chemically treated with 5% Sodium hydroxide (NaOH) and 5% magnesium carbonate (MgCO3) to improvise the properties of the fiber.
32877714	7	90	theme	%	1249:1249	arg1	tensile					1200:1206	tensile	1200:1206	tensile	1200:1206	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	7	90	theme	%	1249:1249	arg1	modulus					1191:1197	Young's modulus	1183:1197	Young's modulus	1183:1197	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	7	90	theme	%	1249:1249	arg1	strength					1222:1229	flexural strength	1213:1229	flexural strength of 8%, 27%, and 16%	1213:1249	Based on the results, 5% MgCO3, 5% plasticizer, and 30% fiber volume showed significant improvement in Young's modulus, tensile, and flexural strength of 8%, 27%, and 16% respectively.
32877714	3	91	theme	%	542:542	arg1	fiber					550:554	chemically treated 5% MgCO3 fiber	522:554	chemically treated 5% MgCO3 fiber	522:554	The mechanical test result shows that chemically treated 5% MgCO3 fiber show that 4% and 24% improved tensile strength compared to NaOH and untreated ones.
33038803	5	0	theme	peak	624:627	arg1	viscosity					629:637	the peak viscosity	620:637	the peak viscosity of flour	620:646	Ozone treatment increased the peak viscosity of flour and the level of increase in heavily-pearled kernels was greater than un-pearled and lightly-pearled.
33038803	7	1	theme	lightly-pearled	966:980	arg1	kernels					982:988	un-pearled and lightly-pearled kernels	951:988	un-pearled and lightly-pearled kernels	951:988	After ozone treatment, un-pearled and lightly-pearled kernels exhibited increases in molecular weight of starch, but heavily-pearled resulted in the opposite trend.
33038803	0	2	theme	ozone	62:66	arg1	treatment					68:76	ozone treatment	62:76	ozone treatment	62:76	Properties of flour from pearled wheat kernels as affected by ozone treatment.
33038803	4	3	from	strength	478:485	arg1	kernels					529:535	un-pearled and pearled kernels	506:535	un-pearled and pearled kernels	506:535	Ozonation enhanced the dough strength of the flours from un-pearled and pearled kernels and the effect elevated with increasing pearling degree.
33038803	6	4	theme	protein	801:807	arg1	content					817:823	the insoluble protein polymer content	787:823	the insoluble protein polymer content of heavily-pearled kernels' flour	787:857	Ozonation resulted in an increase in the insoluble protein polymer content of heavily-pearled kernels' flour, but only had a slight effect on un-pearled lightly-pearled kernels.
33038803	0	5	from	Properties	0:9	arg1	kernels					39:45	pearled wheat kernels	25:45	pearled wheat kernels	25:45	Properties of flour from pearled wheat kernels as affected by ozone treatment.
33038803	6	6	theme	insoluble	791:799	arg1	content					817:823	the insoluble protein polymer content	787:823	the insoluble protein polymer content of heavily-pearled kernels' flour	787:857	Ozonation resulted in an increase in the insoluble protein polymer content of heavily-pearled kernels' flour, but only had a slight effect on un-pearled lightly-pearled kernels.
33038803	5	7	theme	flour	642:646	arg1	viscosity					629:637	the peak viscosity	620:637	the peak viscosity of flour	620:646	Ozone treatment increased the peak viscosity of flour and the level of increase in heavily-pearled kernels was greater than un-pearled and lightly-pearled.
33038803	7	8	theme	ozone	934:938	arg1	treatment					940:948	ozone treatment	934:948	ozone treatment	934:948	After ozone treatment, un-pearled and lightly-pearled kernels exhibited increases in molecular weight of starch, but heavily-pearled resulted in the opposite trend.
33038803	1	9	dep	kernels	119:125	arg1	heavily-pearled					155:169	heavily-pearled	155:169	heavily-pearled	155:169	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels were treated with ozone and evaluated for flour compositions and properties.
33038803	1	9	dep	kernels	119:125	arg1	%					149:149	14.4% and heavily-pearled	145:169	%	149:149	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels were treated with ozone and evaluated for flour compositions and properties.
33038803	1	10	theme	kernels	119:125	arg1	degrees					102:108	Two different pearling degrees	79:108	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels	79:200	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels were treated with ozone and evaluated for flour compositions and properties.
33038803	0	11	from	kernels	39:45	arg1	flour					14:18	flour	14:18	flour from pearled wheat kernels	14:45	Properties of flour from pearled wheat kernels as affected by ozone treatment.
33038803	0	11	from	kernels	39:45	arg1	Properties					0:9	Properties	0:9	Properties of flour from pearled wheat kernels	0:45	Properties of flour from pearled wheat kernels as affected by ozone treatment.
33038803	5	12	theme	Ozone	594:598	arg1	treatment					600:608	Ozone treatment	594:608	Ozone treatment	594:608	Ozone treatment increased the peak viscosity of flour and the level of increase in heavily-pearled kernels was greater than un-pearled and lightly-pearled.
33038803	0	13	theme	wheat	33:37	arg1	kernels					39:45	pearled wheat kernels	25:45	pearled wheat kernels	25:45	Properties of flour from pearled wheat kernels as affected by ozone treatment.
33038803	3	14	theme	kernels	405:411	arg1	brightness					381:390	Flour brightness	375:390	Flour brightness of all three kernels	375:411	Flour brightness of all three kernels was improved after ozone treatment.
33038803	7	15	theme	opposite	1077:1084	arg1	trend					1086:1090	the opposite trend	1073:1090	the opposite trend	1073:1090	After ozone treatment, un-pearled and lightly-pearled kernels exhibited increases in molecular weight of starch, but heavily-pearled resulted in the opposite trend.
33038803	4	16	from	kernels	529:535	arg1	strength					478:485	the dough strength	468:485	the dough strength of the flours from un-pearled and pearled kernels	468:535	Ozonation enhanced the dough strength of the flours from un-pearled and pearled kernels and the effect elevated with increasing pearling degree.
33038803	4	16	from	kernels	529:535	arg1	flours					494:499	the flours	490:499	the flours from un-pearled and pearled kernels	490:535	Ozonation enhanced the dough strength of the flours from un-pearled and pearled kernels and the effect elevated with increasing pearling degree.
33038803	4	17	theme	pearled	521:527	arg1	kernels					529:535	un-pearled and pearled kernels	506:535	un-pearled and pearled kernels	506:535	Ozonation enhanced the dough strength of the flours from un-pearled and pearled kernels and the effect elevated with increasing pearling degree.
33038803	1	18	theme	flour	244:248	arg1	compositions					250:261	flour compositions	244:261	flour compositions	244:261	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels were treated with ozone and evaluated for flour compositions and properties.
33038803	5	19	theme	increase	665:672	arg1	level					656:660	the level	652:660	the level of increase in heavily-pearled kernels	652:699	Ozone treatment increased the peak viscosity of flour and the level of increase in heavily-pearled kernels was greater than un-pearled and lightly-pearled.
33038803	5	19	theme	increase	665:672	arg1	greater					705:711	greater	705:711	greater	705:711	Ozone treatment increased the peak viscosity of flour and the level of increase in heavily-pearled kernels was greater than un-pearled and lightly-pearled.
33038803	1	20	theme	different	83:91	arg1	degrees					102:108	Two different pearling degrees	79:108	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels	79:200	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels were treated with ozone and evaluated for flour compositions and properties.
33038803	7	21	from	increases	1000:1008	arg1	weight					1023:1028	molecular weight	1013:1028	molecular weight of starch	1013:1038	After ozone treatment, un-pearled and lightly-pearled kernels exhibited increases in molecular weight of starch, but heavily-pearled resulted in the opposite trend.
33038803	0	22	theme	flour	14:18	arg1	Properties					0:9	Properties	0:9	Properties of flour from pearled wheat kernels	0:45	Properties of flour from pearled wheat kernels as affected by ozone treatment.
33038803	4	23	theme	pearling	577:584	arg1	degree					586:591	pearling degree	577:591	pearling degree	577:591	Ozonation enhanced the dough strength of the flours from un-pearled and pearled kernels and the effect elevated with increasing pearling degree.
33038803	1	24	theme	pearling	93:100	arg1	degrees					102:108	Two different pearling degrees	79:108	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels	79:200	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels were treated with ozone and evaluated for flour compositions and properties.
33038803	3	25	theme	ozone	432:436	arg1	treatment					438:446	ozone treatment	432:446	ozone treatment	432:446	Flour brightness of all three kernels was improved after ozone treatment.
33038803	3	26	theme	Flour	375:379	arg1	brightness					381:390	Flour brightness	375:390	Flour brightness of all three kernels	375:411	Flour brightness of all three kernels was improved after ozone treatment.
33038803	5	27	theme	heavily-pearled	677:691	arg1	kernels					693:699	heavily-pearled kernels	677:699	heavily-pearled kernels	677:699	Ozone treatment increased the peak viscosity of flour and the level of increase in heavily-pearled kernels was greater than un-pearled and lightly-pearled.
33038803	6	28	theme	flour	853:857	arg1	content					817:823	the insoluble protein polymer content	787:823	the insoluble protein polymer content of heavily-pearled kernels' flour	787:857	Ozonation resulted in an increase in the insoluble protein polymer content of heavily-pearled kernels' flour, but only had a slight effect on un-pearled lightly-pearled kernels.
33038803	6	29	contain	had	869:871	arg2	effect					882:887	a slight effect	873:887	a slight effect	873:887	Ozonation resulted in an increase in the insoluble protein polymer content of heavily-pearled kernels' flour, but only had a slight effect on un-pearled lightly-pearled kernels.
33038803	6	29	contain	had	869:871	arg1	Ozonation					750:758	Ozonation	750:758	Ozonation	750:758	Ozonation resulted in an increase in the insoluble protein polymer content of heavily-pearled kernels' flour, but only had a slight effect on un-pearled lightly-pearled kernels.
33038803	0	30	theme	pearled	25:31	arg1	kernels					39:45	pearled wheat kernels	25:45	pearled wheat kernels	25:45	Properties of flour from pearled wheat kernels as affected by ozone treatment.
33038803	4	31	theme	flours	494:499	arg1	strength					478:485	the dough strength	468:485	the dough strength of the flours from un-pearled and pearled kernels	468:535	Ozonation enhanced the dough strength of the flours from un-pearled and pearled kernels and the effect elevated with increasing pearling degree.
33038803	7	32	theme	molecular	1013:1021	arg1	weight					1023:1028	molecular weight	1013:1028	molecular weight of starch	1013:1038	After ozone treatment, un-pearled and lightly-pearled kernels exhibited increases in molecular weight of starch, but heavily-pearled resulted in the opposite trend.
33038803	1	33	dep	%	149:149	arg1	%					176:176	38.9%	172:176	lightly-pearled: 14.4% and heavily-pearled: 38.9%	128:176	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels were treated with ozone and evaluated for flour compositions and properties.
33038803	6	34	theme	slight	875:880	arg1	effect					882:887	a slight effect	873:887	a slight effect	873:887	Ozonation resulted in an increase in the insoluble protein polymer content of heavily-pearled kernels' flour, but only had a slight effect on un-pearled lightly-pearled kernels.
33038803	4	35	theme	un-pearled	506:515	arg1	kernels					529:535	un-pearled and pearled kernels	506:535	un-pearled and pearled kernels	506:535	Ozonation enhanced the dough strength of the flours from un-pearled and pearled kernels and the effect elevated with increasing pearling degree.
33038803	6	36	theme	un-pearled	892:901	arg1	kernels					919:925	un-pearled lightly-pearled kernels	892:925	un-pearled lightly-pearled kernels	892:925	Ozonation resulted in an increase in the insoluble protein polymer content of heavily-pearled kernels' flour, but only had a slight effect on un-pearled lightly-pearled kernels.
33038803	6	37	theme	heavily-pearled	828:842	arg1	kernels					844:850	heavily-pearled kernels'	828:851	heavily-pearled kernels' flour	828:857	Ozonation resulted in an increase in the insoluble protein polymer content of heavily-pearled kernels' flour, but only had a slight effect on un-pearled lightly-pearled kernels.
33038803	2	38	theme	main	304:307	arg1	compositions					309:320	main compositions	304:320	main compositions	304:320	Ozonation did not change main compositions and damaged starch content of three kernels' flours.
33038803	6	39	theme	lightly-pearled	903:917	arg1	kernels					919:925	un-pearled lightly-pearled kernels	892:925	un-pearled lightly-pearled kernels	892:925	Ozonation resulted in an increase in the insoluble protein polymer content of heavily-pearled kernels' flour, but only had a slight effect on un-pearled lightly-pearled kernels.
33038803	7	40	theme	un-pearled	951:960	arg1	kernels					982:988	un-pearled and lightly-pearled kernels	951:988	un-pearled and lightly-pearled kernels	951:988	After ozone treatment, un-pearled and lightly-pearled kernels exhibited increases in molecular weight of starch, but heavily-pearled resulted in the opposite trend.
33038803	1	41	theme	wheat	113:117	arg1	kernels					119:125	wheat kernels	113:125	wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%)	113:177	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels were treated with ozone and evaluated for flour compositions and properties.
33038803	5	42	from	level	656:660	arg1	kernels					693:699	heavily-pearled kernels	677:699	heavily-pearled kernels	677:699	Ozone treatment increased the peak viscosity of flour and the level of increase in heavily-pearled kernels was greater than un-pearled and lightly-pearled.
33038803	1	43	theme	un-pearled	183:192	arg1	kernels					194:200	un-pearled kernels	183:200	un-pearled kernels	183:200	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels were treated with ozone and evaluated for flour compositions and properties.
33038803	7	44	theme	starch	1033:1038	arg1	weight					1023:1028	molecular weight	1013:1028	molecular weight of starch	1013:1038	After ozone treatment, un-pearled and lightly-pearled kernels exhibited increases in molecular weight of starch, but heavily-pearled resulted in the opposite trend.
33038803	1	45	theme	lightly-pearled	128:142	arg1	%					149:149	14.4% and heavily-pearled	145:169	%	149:149	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels were treated with ozone and evaluated for flour compositions and properties.
33038803	1	46	theme	kernels	194:200	arg1	degrees					102:108	Two different pearling degrees	79:108	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels	79:200	Two different pearling degrees of wheat kernels (lightly-pearled: 14.4% and heavily-pearled: 38.9%) and un-pearled kernels were treated with ozone and evaluated for flour compositions and properties.
33038803	6	47	theme	polymer	809:815	arg1	content					817:823	the insoluble protein polymer content	787:823	the insoluble protein polymer content of heavily-pearled kernels' flour	787:857	Ozonation resulted in an increase in the insoluble protein polymer content of heavily-pearled kernels' flour, but only had a slight effect on un-pearled lightly-pearled kernels.
33038803	4	48	theme	dough	472:476	arg1	strength					478:485	the dough strength	468:485	the dough strength of the flours from un-pearled and pearled kernels	468:535	Ozonation enhanced the dough strength of the flours from un-pearled and pearled kernels and the effect elevated with increasing pearling degree.
33038803	6	49	from	increase	775:782	arg1	content					817:823	the insoluble protein polymer content	787:823	the insoluble protein polymer content of heavily-pearled kernels' flour	787:857	Ozonation resulted in an increase in the insoluble protein polymer content of heavily-pearled kernels' flour, but only had a slight effect on un-pearled lightly-pearled kernels.
33038803	2	50	theme	starch	334:339	arg1	content					341:347	starch content	334:347	starch content of three kernels' flours	334:372	Ozonation did not change main compositions and damaged starch content of three kernels' flours.
35118414	4	0	theme	ovary	470:474	arg1	tissue					476:481	ovary tissue	470:481	ovary tissue	470:481	Recently, a new fixative, Form-Acetic, was developed that is superior for preserving the structure of ovary tissue and allows investigation of ovary composition.
35118414	5	1	theme	crucial	596:602	arg1	role					604:607	a crucial role	594:607	a crucial role	594:607	One component of the ovary is hyaluronic acid (HA), which plays a crucial role in normal ovary function and fertility.
35118414	4	2	theme	new	380:382	arg1	Form-Acetic					394:404	Form-Acetic	394:404	Form-Acetic	394:404	Recently, a new fixative, Form-Acetic, was developed that is superior for preserving the structure of ovary tissue and allows investigation of ovary composition.
35118414	4	2	theme	new	380:382	arg1	fixative					384:391	a new fixative	378:391	a new fixative	378:391	Recently, a new fixative, Form-Acetic, was developed that is superior for preserving the structure of ovary tissue and allows investigation of ovary composition.
35118414	1	3	dep	tissues	88:94	arg1	understand					146:155	understand	146:155	to understand anatomy	143:163	To visualise tissues to determine the presence of disease or simply to understand anatomy, it is important to preserve fresh tissue.
35118414	1	3	dep	tissues	88:94	arg1	determine					99:107	determine	99:107	to determine the presence of disease	96:131	To visualise tissues to determine the presence of disease or simply to understand anatomy, it is important to preserve fresh tissue.
35118414	0	4	from	Fixation	0:7	arg1	Form-Acetic					12:22	Form-Acetic	12:22	Form-Acetic	12:22	Fixation in Form-Acetic allows hyaluronic acid detection in mouse ovaries.
35118414	2	5	theme	microscopic	273:283	arg1	evaluation					285:294	microscopic evaluation	273:294	microscopic evaluation	273:294	Fixatives are chemical solutions that preserve tissues to enable microscopic evaluation.
35118414	5	6	theme	normal	612:617	arg1	function					625:632	normal ovary function	612:632	normal ovary function	612:632	One component of the ovary is hyaluronic acid (HA), which plays a crucial role in normal ovary function and fertility.
35118414	0	7	from	detection	47:55	arg1	ovaries					66:72	mouse ovaries	60:72	mouse ovaries	60:72	Fixation in Form-Acetic allows hyaluronic acid detection in mouse ovaries.
35118414	9	8	theme	HA	1011:1012	arg1	detection					998:1006	the detection	994:1006	the detection of HA	994:1012	All HA-containing structures in the ovary were clearly distinguished which proves that the novel fixative allows the detection of HA.
35118414	9	9	theme	HA-containing	885:897	arg1	structures					899:908	All HA-containing structures	881:908	All HA-containing structures in the ovary	881:921	All HA-containing structures in the ovary were clearly distinguished which proves that the novel fixative allows the detection of HA.
35118414	9	10	from	structures	899:908	arg1	ovary					917:921	the ovary	913:921	the ovary	913:921	All HA-containing structures in the ovary were clearly distinguished which proves that the novel fixative allows the detection of HA.
35118414	8	11	theme	mouse	820:824	arg1	ovaries					826:832	adult mouse ovaries	814:832	adult mouse ovaries	814:832	In this study, adult mouse ovaries were fixed in Form-Acetic and HA was detected.
35118414	5	12	theme	ovary	551:555	arg1	component					534:542	One component	530:542	One component of the ovary	530:555	One component of the ovary is hyaluronic acid (HA), which plays a crucial role in normal ovary function and fertility.
35118414	1	13	theme	visualise	78:86	arg1	tissues					88:94	visualise tissues	78:94	visualise tissues to determine the presence of disease or simply to understand anatomy	78:163	To visualise tissues to determine the presence of disease or simply to understand anatomy, it is important to preserve fresh tissue.
35118414	8	14	theme	adult	814:818	arg1	ovaries					826:832	adult mouse ovaries	814:832	adult mouse ovaries	814:832	In this study, adult mouse ovaries were fixed in Form-Acetic and HA was detected.
35118414	8	15	from	Form-Acetic	848:858	arg1	fixed					839:843	fixed	839:843	fixed	839:843	In this study, adult mouse ovaries were fixed in Form-Acetic and HA was detected.
35118414	3	16	theme	cells	361:365	arg1	shrinkage					348:356	shrinkage	348:356	shrinkage of cells	348:365	However, some fixatives introduce artefact such as shrinkage of cells.
35118414	5	17	theme	hyaluronic	560:569	arg1	HA					577:578	HA	577:578	HA	577:578	One component of the ovary is hyaluronic acid (HA), which plays a crucial role in normal ovary function and fertility.
35118414	5	17	theme	hyaluronic	560:569	arg1	acid					571:574	hyaluronic acid	560:574	hyaluronic acid (HA)	560:579	One component of the ovary is hyaluronic acid (HA), which plays a crucial role in normal ovary function and fertility.
35118414	0	18	theme	acid	42:45	arg1	detection					47:55	hyaluronic acid detection	31:55	hyaluronic acid detection in mouse ovaries	31:72	Fixation in Form-Acetic allows hyaluronic acid detection in mouse ovaries.
35118414	0	19	theme	hyaluronic	31:40	arg1	detection					47:55	hyaluronic acid detection	31:55	hyaluronic acid detection in mouse ovaries	31:72	Fixation in Form-Acetic allows hyaluronic acid detection in mouse ovaries.
35118414	1	20	theme	fresh	194:198	arg1	tissue					200:205	fresh tissue	194:205	fresh tissue	194:205	To visualise tissues to determine the presence of disease or simply to understand anatomy, it is important to preserve fresh tissue.
35118414	5	21	theme	ovary	619:623	arg1	function					625:632	normal ovary function	612:632	normal ovary function	612:632	One component of the ovary is hyaluronic acid (HA), which plays a crucial role in normal ovary function and fertility.
35118414	4	22	theme	composition	517:527	arg1	investigation					494:506	investigation	494:506	investigation of ovary composition	494:527	Recently, a new fixative, Form-Acetic, was developed that is superior for preserving the structure of ovary tissue and allows investigation of ovary composition.
35118414	8	23	from	study	807:811	arg1	fixed					839:843	fixed	839:843	fixed	839:843	In this study, adult mouse ovaries were fixed in Form-Acetic and HA was detected.
35118414	4	24	theme	ovary	511:515	arg1	composition					517:527	ovary composition	511:527	ovary composition	511:527	Recently, a new fixative, Form-Acetic, was developed that is superior for preserving the structure of ovary tissue and allows investigation of ovary composition.
35118414	6	25	theme	fixative	691:698	arg1	solutions					700:708	different fixative solutions	681:708	different fixative solutions	681:708	Importantly, HA is sensitive to different fixative solutions.
35118414	8	26	from	fixed	839:843	arg1	study					807:811	this study	802:811	this study	802:811	In this study, adult mouse ovaries were fixed in Form-Acetic and HA was detected.
35118414	8	26	from	fixed	839:843	arg1	Form-Acetic					848:858	Form-Acetic	848:858	Form-Acetic	848:858	In this study, adult mouse ovaries were fixed in Form-Acetic and HA was detected.
35118414	6	27	theme	different	681:689	arg1	solutions					700:708	different fixative solutions	681:708	different fixative solutions	681:708	Importantly, HA is sensitive to different fixative solutions.
35118414	1	28	theme	disease	125:131	arg1	presence					113:120	the presence	109:120	the presence of disease	109:131	To visualise tissues to determine the presence of disease or simply to understand anatomy, it is important to preserve fresh tissue.
35118414	9	29	theme	novel	972:976	arg1	fixative					978:985	the novel fixative	968:985	the novel fixative	968:985	All HA-containing structures in the ovary were clearly distinguished which proves that the novel fixative allows the detection of HA.
35118414	0	30	theme	mouse	60:64	arg1	ovaries					66:72	mouse ovaries	60:72	mouse ovaries	60:72	Fixation in Form-Acetic allows hyaluronic acid detection in mouse ovaries.
35118414	4	31	theme	tissue	476:481	arg1	structure					457:465	the structure	453:465	the structure of ovary tissue	453:481	Recently, a new fixative, Form-Acetic, was developed that is superior for preserving the structure of ovary tissue and allows investigation of ovary composition.
35118414	2	32	theme	chemical	222:229	arg1	Fixatives					208:216	Fixatives	208:216	Fixatives	208:216	Fixatives are chemical solutions that preserve tissues to enable microscopic evaluation.
35118414	2	32	theme	chemical	222:229	arg1	solutions					231:239	chemical solutions	222:239	chemical solutions that preserve tissues to enable microscopic evaluation	222:294	Fixatives are chemical solutions that preserve tissues to enable microscopic evaluation.
33031920	9	0	theme	genes	1745:1749	arg1	expression					1700:1709	expression	1700:1709	expression of hippocampal glutamate receptor genes in young, weaning-age offspring	1700:1781	Maternal B-GOS supplementation increased exploratory behavior and reduced expression of hippocampal glutamate receptor genes in young, weaning-age offspring.
33031920	11	1	theme	receptor	1977:1984	arg1	subunits					1986:1993	cortical glutamate receptor subunits	1958:1993	cortical glutamate receptor subunits in females	1958:2004	Finally, in adult offspring, perinatal B-GOS intake increased cortical glutamate receptor subunits in females, increased social preference, and reduced anxiety.
33031920	9	2	theme	young	1754:1758	arg1	offspring					1773:1781	young, weaning-age offspring	1754:1781	young, weaning-age offspring	1754:1781	Maternal B-GOS supplementation increased exploratory behavior and reduced expression of hippocampal glutamate receptor genes in young, weaning-age offspring.
33031920	6	3	theme	B-GOS	1204:1208	arg1	intake					1210:1215	prenatal and postnatal maternal B-GOS intake	1172:1215	prenatal and postnatal maternal B-GOS intake	1172:1215	Offspring behavior was tested at weaning age or adulthood, and a cross-foster design was employed in a separate cohort to differentiate between effects of prenatal and postnatal maternal B-GOS intake.
33031920	9	4	theme	B-GOS	1635:1639	arg1	supplementation					1641:1655	Maternal B-GOS supplementation	1626:1655	Maternal B-GOS supplementation	1626:1655	Maternal B-GOS supplementation increased exploratory behavior and reduced expression of hippocampal glutamate receptor genes in young, weaning-age offspring.
33031920	4	5	theme	endotoxin-challenged	832:851	arg1	offspring					853:861	naïve and endotoxin-challenged offspring	822:861	naïve and endotoxin-challenged offspring	822:861	The aim of this study was to test whether maternal galacto-oligosaccharide intake during pregnancy and lactation alters the brain and behavior in naïve and endotoxin-challenged offspring.
33031920	6	6	theme	postnatal	1185:1193	arg1	intake					1210:1215	prenatal and postnatal maternal B-GOS intake	1172:1215	prenatal and postnatal maternal B-GOS intake	1172:1215	Offspring behavior was tested at weaning age or adulthood, and a cross-foster design was employed in a separate cohort to differentiate between effects of prenatal and postnatal maternal B-GOS intake.
33031920	3	7	theme	development	514:524	arg1	stages					504:509	the earliest stages	491:509	the earliest stages of development	491:524	Despite the brain being most susceptible to environmental factors, such as nutrients and toxins, during the earliest stages of development, it is unknown whether maternal prebiotic supplementation during gestation and lactation influences the offspring gut microbiome, brain, or behavior.
33031920	5	8	theme	female	868:873	arg1	mice					875:878	CD1 female mice	864:878	CD1 female mice	864:878	CD1 female mice received either normal drinking water or water supplemented with Bimuno® galacto-oligosaccharides (B-GOS) during gestation and suckling.
33031920	10	9	theme	propionate	1877:1886	arg1	levels					1888:1893	fecal butyrate and propionate levels	1858:1893	fecal butyrate and propionate levels	1858:1893	In addition, postnatal, but not prenatal, B-GOS supplementation increased fecal butyrate and propionate levels.
33031920	6	10	theme	prenatal	1172:1179	arg1	intake					1210:1215	prenatal and postnatal maternal B-GOS intake	1172:1215	prenatal and postnatal maternal B-GOS intake	1172:1215	Offspring behavior was tested at weaning age or adulthood, and a cross-foster design was employed in a separate cohort to differentiate between effects of prenatal and postnatal maternal B-GOS intake.
33031920	3	11	theme	maternal	549:556	arg1	supplementation					568:582	maternal prebiotic supplementation	549:582	maternal prebiotic supplementation during gestation and lactation	549:613	Despite the brain being most susceptible to environmental factors, such as nutrients and toxins, during the earliest stages of development, it is unknown whether maternal prebiotic supplementation during gestation and lactation influences the offspring gut microbiome, brain, or behavior.
33031920	1	12	theme	enteric	168:174	arg1	microbes					176:183	enteric microbes	168:183	enteric microbes	168:183	Compelling evidence links enteric microbes to brain function and behavior.
33031920	12	13	theme	microbiome	2202:2211	arg1	composition					2213:2223	gut microbiome composition	2198:2223	gut microbiome composition	2198:2223	We provide novel and comprehensive evidence for the influence of maternal prebiotic intake on offspring behavior, brain gene expression, and gut microbiome composition in mice.
33031920	10	14	theme	butyrate	1864:1871	arg1	levels					1888:1893	fecal butyrate and propionate levels	1858:1893	fecal butyrate and propionate levels	1858:1893	In addition, postnatal, but not prenatal, B-GOS supplementation increased fecal butyrate and propionate levels.
33031920	8	15	theme	potential	1501:1509	arg1	relationships					1511:1523	potential relationships	1501:1523	potential relationships between the maternal microbiome, the offspring gut microbiome, and the offspring brain and behavior	1501:1623	Fecal microbiome composition and metabolites were analyzed to explore potential relationships between the maternal microbiome, the offspring gut microbiome, and the offspring brain and behavior.
33031920	4	16	theme	study	692:696	arg1	aim					680:682	The aim	676:682	The aim of this study	676:696	The aim of this study was to test whether maternal galacto-oligosaccharide intake during pregnancy and lactation alters the brain and behavior in naïve and endotoxin-challenged offspring.
33031920	11	17	theme	adult	1908:1912	arg1	offspring					1914:1922	adult offspring	1908:1922	adult offspring	1908:1922	Finally, in adult offspring, perinatal B-GOS intake increased cortical glutamate receptor subunits in females, increased social preference, and reduced anxiety.
33031920	4	18	from	behavior	810:817	arg1	offspring					853:861	naïve and endotoxin-challenged offspring	822:861	naïve and endotoxin-challenged offspring	822:861	The aim of this study was to test whether maternal galacto-oligosaccharide intake during pregnancy and lactation alters the brain and behavior in naïve and endotoxin-challenged offspring.
33031920	12	19	theme	comprehensive	2078:2090	arg1	evidence					2092:2099	novel and comprehensive evidence	2068:2099	novel and comprehensive evidence for the influence of maternal prebiotic intake on offspring behavior, brain gene expression, and gut microbiome composition in mice	2068:2231	We provide novel and comprehensive evidence for the influence of maternal prebiotic intake on offspring behavior, brain gene expression, and gut microbiome composition in mice.
33031920	8	20	theme	maternal	1537:1544	arg1	microbiome					1546:1555	the maternal microbiome	1533:1555	the maternal microbiome	1533:1555	Fecal microbiome composition and metabolites were analyzed to explore potential relationships between the maternal microbiome, the offspring gut microbiome, and the offspring brain and behavior.
33031920	7	21	theme	pro-inflammatory	1390:1405	arg1	challenge					1407:1415	a neonatal pro-inflammatory challenge	1379:1415	a neonatal pro-inflammatory challenge	1379:1415	Lipopolysaccharide was also administered to pups at postnatal day 9 to determine whether maternal B-GOS influences the neurobiological and behavioral effects of a neonatal pro-inflammatory challenge in adulthood.
33031920	8	22	theme	Fecal	1431:1435	arg1	composition					1448:1458	Fecal microbiome composition	1431:1458	Fecal microbiome composition	1431:1458	Fecal microbiome composition and metabolites were analyzed to explore potential relationships between the maternal microbiome, the offspring gut microbiome, and the offspring brain and behavior.
33031920	4	23	from	brain	800:804	arg1	offspring					853:861	naïve and endotoxin-challenged offspring	822:861	naïve and endotoxin-challenged offspring	822:861	The aim of this study was to test whether maternal galacto-oligosaccharide intake during pregnancy and lactation alters the brain and behavior in naïve and endotoxin-challenged offspring.
33031920	5	24	theme	normal	896:901	arg1	water					912:916	normal drinking water	896:916	normal drinking water	896:916	CD1 female mice received either normal drinking water or water supplemented with Bimuno® galacto-oligosaccharides (B-GOS) during gestation and suckling.
33031920	8	25	theme	offspring	1562:1570	arg1	microbiome					1576:1585	the offspring gut microbiome	1558:1585	the offspring gut microbiome	1558:1585	Fecal microbiome composition and metabolites were analyzed to explore potential relationships between the maternal microbiome, the offspring gut microbiome, and the offspring brain and behavior.
33031920	12	26	theme	brain	2171:2175	arg1	expression					2182:2191	brain gene expression	2171:2191	brain gene expression	2171:2191	We provide novel and comprehensive evidence for the influence of maternal prebiotic intake on offspring behavior, brain gene expression, and gut microbiome composition in mice.
33031920	6	27	theme	Offspring	1017:1025	arg1	behavior					1027:1034	Offspring behavior	1017:1034	Offspring behavior	1017:1034	Offspring behavior was tested at weaning age or adulthood, and a cross-foster design was employed in a separate cohort to differentiate between effects of prenatal and postnatal maternal B-GOS intake.
33031920	0	28	theme	brain	81:85	arg1	expression					92:101	brain gene expression	81:101	brain gene expression	81:101	Mom's diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring.
33031920	9	29	theme	Maternal	1626:1633	arg1	supplementation					1641:1655	Maternal B-GOS supplementation	1626:1655	Maternal B-GOS supplementation	1626:1655	Maternal B-GOS supplementation increased exploratory behavior and reduced expression of hippocampal glutamate receptor genes in young, weaning-age offspring.
33031920	6	30	theme	cross-foster	1082:1093	arg1	design					1095:1100	a cross-foster design	1080:1100	a cross-foster design	1080:1100	Offspring behavior was tested at weaning age or adulthood, and a cross-foster design was employed in a separate cohort to differentiate between effects of prenatal and postnatal maternal B-GOS intake.
33031920	2	31	theme	adult	372:376	arg1	rodents					378:384	adult rodents	372:384	adult rodents	372:384	Galacto-oligosaccharide prebiotics have been shown to modulate the composition of gut flora and induce metabolic, neurochemical, and behavioral changes in adult rodents.
33031920	7	32	theme	behavioral	1357:1366	arg1	effects					1368:1374	the neurobiological and behavioral effects	1333:1374	the neurobiological and behavioral effects of a neonatal pro-inflammatory challenge in adulthood	1333:1428	Lipopolysaccharide was also administered to pups at postnatal day 9 to determine whether maternal B-GOS influences the neurobiological and behavioral effects of a neonatal pro-inflammatory challenge in adulthood.
33031920	4	33	theme	galacto-oligosaccharide	727:749	arg1	intake					751:756	maternal galacto-oligosaccharide intake	718:756	maternal galacto-oligosaccharide intake during pregnancy and lactation	718:787	The aim of this study was to test whether maternal galacto-oligosaccharide intake during pregnancy and lactation alters the brain and behavior in naïve and endotoxin-challenged offspring.
33031920	0	34	theme	diet	6:9	arg1	matters					11:17	Mom's diet matters	0:17	Mom's diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring.	0:140	Mom's diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring.
33031920	9	35	theme	exploratory	1667:1677	arg1	behavior					1679:1686	exploratory behavior	1667:1686	exploratory behavior	1667:1686	Maternal B-GOS supplementation increased exploratory behavior and reduced expression of hippocampal glutamate receptor genes in young, weaning-age offspring.
33031920	7	36	theme	neurobiological	1337:1351	arg1	effects					1368:1374	the neurobiological and behavioral effects	1333:1374	the neurobiological and behavioral effects of a neonatal pro-inflammatory challenge in adulthood	1333:1428	Lipopolysaccharide was also administered to pups at postnatal day 9 to determine whether maternal B-GOS influences the neurobiological and behavioral effects of a neonatal pro-inflammatory challenge in adulthood.
33031920	5	37	theme	CD1	864:866	arg1	mice					875:878	CD1 female mice	864:878	CD1 female mice	864:878	CD1 female mice received either normal drinking water or water supplemented with Bimuno® galacto-oligosaccharides (B-GOS) during gestation and suckling.
33031920	3	38	theme	gut	640:642	arg1	microbiome					644:653	the offspring gut microbiome	626:653	the offspring gut microbiome	626:653	Despite the brain being most susceptible to environmental factors, such as nutrients and toxins, during the earliest stages of development, it is unknown whether maternal prebiotic supplementation during gestation and lactation influences the offspring gut microbiome, brain, or behavior.
33031920	4	39	theme	naïve	822:826	arg1	offspring					853:861	naïve and endotoxin-challenged offspring	822:861	naïve and endotoxin-challenged offspring	822:861	The aim of this study was to test whether maternal galacto-oligosaccharide intake during pregnancy and lactation alters the brain and behavior in naïve and endotoxin-challenged offspring.
33031920	2	40	theme	neurochemical	331:343	arg1	changes					361:367	metabolic, neurochemical, and behavioral changes	320:367	metabolic, neurochemical, and behavioral changes in adult rodents	320:384	Galacto-oligosaccharide prebiotics have been shown to modulate the composition of gut flora and induce metabolic, neurochemical, and behavioral changes in adult rodents.
33031920	0	41	theme	prebiotic	29:37	arg1	intake					39:44	Maternal prebiotic intake	20:44	Maternal prebiotic intake in mice	20:52	Mom's diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring.
33031920	7	42	theme	maternal	1307:1314	arg1	B-GOS					1316:1320	maternal B-GOS	1307:1320	maternal B-GOS	1307:1320	Lipopolysaccharide was also administered to pups at postnatal day 9 to determine whether maternal B-GOS influences the neurobiological and behavioral effects of a neonatal pro-inflammatory challenge in adulthood.
33031920	6	43	theme	intake	1210:1215	arg1	effects					1161:1167	effects	1161:1167	effects of prenatal and postnatal maternal B-GOS intake	1161:1215	Offspring behavior was tested at weaning age or adulthood, and a cross-foster design was employed in a separate cohort to differentiate between effects of prenatal and postnatal maternal B-GOS intake.
33031920	11	44	theme	B-GOS	1935:1939	arg1	intake					1941:1946	perinatal B-GOS intake	1925:1946	perinatal B-GOS intake	1925:1946	Finally, in adult offspring, perinatal B-GOS intake increased cortical glutamate receptor subunits in females, increased social preference, and reduced anxiety.
33031920	10	45	theme	B-GOS	1826:1830	arg1	supplementation					1832:1846	postnatal, but not prenatal, B-GOS supplementation	1797:1846	postnatal, but not prenatal, B-GOS supplementation	1797:1846	In addition, postnatal, but not prenatal, B-GOS supplementation increased fecal butyrate and propionate levels.
33031920	9	46	theme	hippocampal	1714:1724	arg1	genes					1745:1749	hippocampal glutamate receptor genes	1714:1749	hippocampal glutamate receptor genes	1714:1749	Maternal B-GOS supplementation increased exploratory behavior and reduced expression of hippocampal glutamate receptor genes in young, weaning-age offspring.
33031920	6	47	theme	separate	1120:1127	arg1	cohort					1129:1134	a separate cohort	1118:1134	a separate cohort	1118:1134	Offspring behavior was tested at weaning age or adulthood, and a cross-foster design was employed in a separate cohort to differentiate between effects of prenatal and postnatal maternal B-GOS intake.
33031920	3	48	theme	earliest	495:502	arg1	stages					504:509	the earliest stages	491:509	the earliest stages of development	491:524	Despite the brain being most susceptible to environmental factors, such as nutrients and toxins, during the earliest stages of development, it is unknown whether maternal prebiotic supplementation during gestation and lactation influences the offspring gut microbiome, brain, or behavior.
33031920	12	49	theme	maternal	2122:2129	arg1	intake					2141:2146	maternal prebiotic intake	2122:2146	maternal prebiotic intake	2122:2146	We provide novel and comprehensive evidence for the influence of maternal prebiotic intake on offspring behavior, brain gene expression, and gut microbiome composition in mice.
33031920	9	50	theme	receptor	1736:1743	arg1	genes					1745:1749	hippocampal glutamate receptor genes	1714:1749	hippocampal glutamate receptor genes	1714:1749	Maternal B-GOS supplementation increased exploratory behavior and reduced expression of hippocampal glutamate receptor genes in young, weaning-age offspring.
33031920	7	51	from	effects	1368:1374	arg1	adulthood					1420:1428	adulthood	1420:1428	adulthood	1420:1428	Lipopolysaccharide was also administered to pups at postnatal day 9 to determine whether maternal B-GOS influences the neurobiological and behavioral effects of a neonatal pro-inflammatory challenge in adulthood.
33031920	0	52	from	expression	92:101	arg1	offspring					131:139	offspring	131:139	offspring	131:139	Mom's diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring.
33031920	11	53	theme	glutamate	1967:1975	arg1	subunits					1986:1993	cortical glutamate receptor subunits	1958:1993	cortical glutamate receptor subunits in females	1958:2004	Finally, in adult offspring, perinatal B-GOS intake increased cortical glutamate receptor subunits in females, increased social preference, and reduced anxiety.
33031920	12	54	theme	intake	2141:2146	arg1	influence					2109:2117	the influence	2105:2117	the influence of maternal prebiotic intake on offspring behavior, brain gene expression, and gut microbiome composition in mice	2105:2231	We provide novel and comprehensive evidence for the influence of maternal prebiotic intake on offspring behavior, brain gene expression, and gut microbiome composition in mice.
33031920	7	55	theme	postnatal	1270:1278	arg1	day					1280:1282	postnatal day 9	1270:1284	postnatal day 9	1270:1284	Lipopolysaccharide was also administered to pups at postnatal day 9 to determine whether maternal B-GOS influences the neurobiological and behavioral effects of a neonatal pro-inflammatory challenge in adulthood.
33031920	10	56	theme	fecal	1858:1862	arg1	levels					1888:1893	fecal butyrate and propionate levels	1858:1893	fecal butyrate and propionate levels	1858:1893	In addition, postnatal, but not prenatal, B-GOS supplementation increased fecal butyrate and propionate levels.
33031920	7	57	from	day	1280:1282	arg1	pups					1262:1265	pups	1262:1265	pups at postnatal day 9	1262:1284	Lipopolysaccharide was also administered to pups at postnatal day 9 to determine whether maternal B-GOS influences the neurobiological and behavioral effects of a neonatal pro-inflammatory challenge in adulthood.
33031920	6	58	theme	maternal	1195:1202	arg1	intake					1210:1215	prenatal and postnatal maternal B-GOS intake	1172:1215	prenatal and postnatal maternal B-GOS intake	1172:1215	Offspring behavior was tested at weaning age or adulthood, and a cross-foster design was employed in a separate cohort to differentiate between effects of prenatal and postnatal maternal B-GOS intake.
33031920	0	59	from	microbiome	117:126	arg1	offspring					131:139	offspring	131:139	offspring	131:139	Mom's diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring.
33031920	1	60	theme	Compelling	142:151	arg1	evidence					153:160	Compelling evidence	142:160	Compelling evidence	142:160	Compelling evidence links enteric microbes to brain function and behavior.
33031920	12	61	theme	novel	2068:2072	arg1	evidence					2092:2099	novel and comprehensive evidence	2068:2099	novel and comprehensive evidence for the influence of maternal prebiotic intake on offspring behavior, brain gene expression, and gut microbiome composition in mice	2068:2231	We provide novel and comprehensive evidence for the influence of maternal prebiotic intake on offspring behavior, brain gene expression, and gut microbiome composition in mice.
33031920	2	62	from	changes	361:367	arg1	rodents					378:384	adult rodents	372:384	adult rodents	372:384	Galacto-oligosaccharide prebiotics have been shown to modulate the composition of gut flora and induce metabolic, neurochemical, and behavioral changes in adult rodents.
33031920	2	63	theme	gut	299:301	arg1	flora					303:307	gut flora	299:307	gut flora	299:307	Galacto-oligosaccharide prebiotics have been shown to modulate the composition of gut flora and induce metabolic, neurochemical, and behavioral changes in adult rodents.
33031920	2	64	theme	flora	303:307	arg1	composition					284:294	the composition	280:294	the composition of gut flora	280:307	Galacto-oligosaccharide prebiotics have been shown to modulate the composition of gut flora and induce metabolic, neurochemical, and behavioral changes in adult rodents.
33031920	12	65	theme	gut	2198:2200	arg1	composition					2213:2223	gut microbiome composition	2198:2223	gut microbiome composition	2198:2223	We provide novel and comprehensive evidence for the influence of maternal prebiotic intake on offspring behavior, brain gene expression, and gut microbiome composition in mice.
33031920	11	66	theme	cortical	1958:1965	arg1	subunits					1986:1993	cortical glutamate receptor subunits	1958:1993	cortical glutamate receptor subunits in females	1958:2004	Finally, in adult offspring, perinatal B-GOS intake increased cortical glutamate receptor subunits in females, increased social preference, and reduced anxiety.
33031920	0	67	theme	fecal	111:115	arg1	microbiome					117:126	the fecal microbiome	107:126	the fecal microbiome	107:126	Mom's diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring.
33031920	2	68	theme	Galacto-oligosaccharide	217:239	arg1	prebiotics					241:250	Galacto-oligosaccharide prebiotics	217:250	Galacto-oligosaccharide prebiotics	217:250	Galacto-oligosaccharide prebiotics have been shown to modulate the composition of gut flora and induce metabolic, neurochemical, and behavioral changes in adult rodents.
33031920	1	69	theme	brain	188:192	arg1	function					194:201	brain function	188:201	brain function	188:201	Compelling evidence links enteric microbes to brain function and behavior.
33031920	1	70	attach	links	162:166	arg1	behavior					207:214	behavior	207:214	behavior	207:214	Compelling evidence links enteric microbes to brain function and behavior.
33031920	1	70	attach	links	162:166	arg2	evidence					153:160	Compelling evidence	142:160	Compelling evidence	142:160	Compelling evidence links enteric microbes to brain function and behavior.
33031920	1	70	attach	links	162:166	arg1	function					194:201	brain function	188:201	brain function	188:201	Compelling evidence links enteric microbes to brain function and behavior.
33031920	11	71	theme	perinatal	1925:1933	arg1	intake					1941:1946	perinatal B-GOS intake	1925:1946	perinatal B-GOS intake	1925:1946	Finally, in adult offspring, perinatal B-GOS intake increased cortical glutamate receptor subunits in females, increased social preference, and reduced anxiety.
33031920	3	72	theme	prebiotic	558:566	arg1	supplementation					568:582	maternal prebiotic supplementation	549:582	maternal prebiotic supplementation during gestation and lactation	549:613	Despite the brain being most susceptible to environmental factors, such as nutrients and toxins, during the earliest stages of development, it is unknown whether maternal prebiotic supplementation during gestation and lactation influences the offspring gut microbiome, brain, or behavior.
33031920	12	73	theme	gene	2177:2180	arg1	expression					2182:2191	brain gene expression	2171:2191	brain gene expression	2171:2191	We provide novel and comprehensive evidence for the influence of maternal prebiotic intake on offspring behavior, brain gene expression, and gut microbiome composition in mice.
33031920	7	74	theme	challenge	1407:1415	arg1	effects					1368:1374	the neurobiological and behavioral effects	1333:1374	the neurobiological and behavioral effects of a neonatal pro-inflammatory challenge in adulthood	1333:1428	Lipopolysaccharide was also administered to pups at postnatal day 9 to determine whether maternal B-GOS influences the neurobiological and behavioral effects of a neonatal pro-inflammatory challenge in adulthood.
33031920	2	75	theme	metabolic	320:328	arg1	changes					361:367	metabolic, neurochemical, and behavioral changes	320:367	metabolic, neurochemical, and behavioral changes in adult rodents	320:384	Galacto-oligosaccharide prebiotics have been shown to modulate the composition of gut flora and induce metabolic, neurochemical, and behavioral changes in adult rodents.
33031920	8	76	theme	gut	1572:1574	arg1	microbiome					1576:1585	the offspring gut microbiome	1558:1585	the offspring gut microbiome	1558:1585	Fecal microbiome composition and metabolites were analyzed to explore potential relationships between the maternal microbiome, the offspring gut microbiome, and the offspring brain and behavior.
33031920	7	77	theme	neonatal	1381:1388	arg1	challenge					1407:1415	a neonatal pro-inflammatory challenge	1379:1415	a neonatal pro-inflammatory challenge	1379:1415	Lipopolysaccharide was also administered to pups at postnatal day 9 to determine whether maternal B-GOS influences the neurobiological and behavioral effects of a neonatal pro-inflammatory challenge in adulthood.
33031920	5	78	theme	drinking	903:910	arg1	water					912:916	normal drinking water	896:916	normal drinking water	896:916	CD1 female mice received either normal drinking water or water supplemented with Bimuno® galacto-oligosaccharides (B-GOS) during gestation and suckling.
33031920	0	79	from	intake	39:44	arg1	mice					49:52	mice	49:52	mice	49:52	Mom's diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring.
33031920	11	80	from	subunits	1986:1993	arg1	females					1998:2004	females	1998:2004	females	1998:2004	Finally, in adult offspring, perinatal B-GOS intake increased cortical glutamate receptor subunits in females, increased social preference, and reduced anxiety.
33031920	0	81	theme	gene	87:90	arg1	expression					92:101	brain gene expression	81:101	brain gene expression	81:101	Mom's diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring.
33031920	6	82	dep	weaning	1050:1056	arg1	age					1058:1060	age	1058:1060	age	1058:1060	Offspring behavior was tested at weaning age or adulthood, and a cross-foster design was employed in a separate cohort to differentiate between effects of prenatal and postnatal maternal B-GOS intake.
33031920	3	83	theme	environmental	431:443	arg1	toxins					476:481	toxins	476:481	toxins	476:481	Despite the brain being most susceptible to environmental factors, such as nutrients and toxins, during the earliest stages of development, it is unknown whether maternal prebiotic supplementation during gestation and lactation influences the offspring gut microbiome, brain, or behavior.
33031920	3	83	theme	environmental	431:443	arg1	nutrients					462:470	nutrients	462:470	nutrients	462:470	Despite the brain being most susceptible to environmental factors, such as nutrients and toxins, during the earliest stages of development, it is unknown whether maternal prebiotic supplementation during gestation and lactation influences the offspring gut microbiome, brain, or behavior.
33031920	3	83	theme	environmental	431:443	arg1	factors					445:451	environmental factors	431:451	environmental factors	431:451	Despite the brain being most susceptible to environmental factors, such as nutrients and toxins, during the earliest stages of development, it is unknown whether maternal prebiotic supplementation during gestation and lactation influences the offspring gut microbiome, brain, or behavior.
33031920	9	84	dep	young	1754:1758	arg1	weaning-age					1761:1771	weaning-age	1761:1771	weaning-age	1761:1771	Maternal B-GOS supplementation increased exploratory behavior and reduced expression of hippocampal glutamate receptor genes in young, weaning-age offspring.
33031920	5	85	theme	Bimuno®	945:951	arg1	galacto-oligosaccharides					953:976	Bimuno® galacto-oligosaccharides	945:976	Bimuno® galacto-oligosaccharides	945:976	CD1 female mice received either normal drinking water or water supplemented with Bimuno® galacto-oligosaccharides (B-GOS) during gestation and suckling.
33031920	9	86	from	expression	1700:1709	arg1	offspring					1773:1781	young, weaning-age offspring	1754:1781	young, weaning-age offspring	1754:1781	Maternal B-GOS supplementation increased exploratory behavior and reduced expression of hippocampal glutamate receptor genes in young, weaning-age offspring.
33031920	4	87	theme	maternal	718:725	arg1	intake					751:756	maternal galacto-oligosaccharide intake	718:756	maternal galacto-oligosaccharide intake during pregnancy and lactation	718:787	The aim of this study was to test whether maternal galacto-oligosaccharide intake during pregnancy and lactation alters the brain and behavior in naïve and endotoxin-challenged offspring.
33031920	0	88	theme	Maternal	20:27	arg1	intake					39:44	Maternal prebiotic intake	20:44	Maternal prebiotic intake in mice	20:52	Mom's diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring.
33031920	3	89	theme	offspring	630:638	arg1	microbiome					644:653	the offspring gut microbiome	626:653	the offspring gut microbiome	626:653	Despite the brain being most susceptible to environmental factors, such as nutrients and toxins, during the earliest stages of development, it is unknown whether maternal prebiotic supplementation during gestation and lactation influences the offspring gut microbiome, brain, or behavior.
33031920	8	90	theme	microbiome	1437:1446	arg1	composition					1448:1458	Fecal microbiome composition	1431:1458	Fecal microbiome composition	1431:1458	Fecal microbiome composition and metabolites were analyzed to explore potential relationships between the maternal microbiome, the offspring gut microbiome, and the offspring brain and behavior.
33031920	4	91	dep	brain	800:804	arg1	the					796:798	the	796:798	the	796:798	The aim of this study was to test whether maternal galacto-oligosaccharide intake during pregnancy and lactation alters the brain and behavior in naïve and endotoxin-challenged offspring.
33031920	10	92	theme	postnatal	1797:1805	arg1	supplementation					1832:1846	postnatal, but not prenatal, B-GOS supplementation	1797:1846	postnatal, but not prenatal, B-GOS supplementation	1797:1846	In addition, postnatal, but not prenatal, B-GOS supplementation increased fecal butyrate and propionate levels.
33031920	0	93	dep	matters	11:17	arg1	reduces					54:60	reduces	54:60	reduces anxiety	54:68	Mom's diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring.
33031920	0	93	dep	matters	11:17	arg1	alters					74:79	alters	74:79	alters brain gene expression and the fecal microbiome in offspring	74:139	Mom's diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring.
33031920	2	94	theme	behavioral	350:359	arg1	changes					361:367	metabolic, neurochemical, and behavioral changes	320:367	metabolic, neurochemical, and behavioral changes in adult rodents	320:384	Galacto-oligosaccharide prebiotics have been shown to modulate the composition of gut flora and induce metabolic, neurochemical, and behavioral changes in adult rodents.
33031920	8	95	dep	offspring	1596:1604	arg1	brain					1606:1610	brain	1606:1610	brain	1606:1610	Fecal microbiome composition and metabolites were analyzed to explore potential relationships between the maternal microbiome, the offspring gut microbiome, and the offspring brain and behavior.
33031920	12	96	theme	prebiotic	2131:2139	arg1	intake					2141:2146	maternal prebiotic intake	2122:2146	maternal prebiotic intake	2122:2146	We provide novel and comprehensive evidence for the influence of maternal prebiotic intake on offspring behavior, brain gene expression, and gut microbiome composition in mice.
33031920	9	97	theme	glutamate	1726:1734	arg1	genes					1745:1749	hippocampal glutamate receptor genes	1714:1749	hippocampal glutamate receptor genes	1714:1749	Maternal B-GOS supplementation increased exploratory behavior and reduced expression of hippocampal glutamate receptor genes in young, weaning-age offspring.
33031920	11	98	theme	social	2017:2022	arg1	preference					2024:2033	social preference	2017:2033	social preference	2017:2033	Finally, in adult offspring, perinatal B-GOS intake increased cortical glutamate receptor subunits in females, increased social preference, and reduced anxiety.
33031920	10	99	theme	prenatal	1816:1823	arg1	supplementation					1832:1846	postnatal, but not prenatal, B-GOS supplementation	1797:1846	postnatal, but not prenatal, B-GOS supplementation	1797:1846	In addition, postnatal, but not prenatal, B-GOS supplementation increased fecal butyrate and propionate levels.
33060635	7	0	theme	acetate	1214:1220	arg1	production					1200:1209	the production	1196:1209	the production of acetate, propionate, and total short-chain fatty acids	1196:1267	In addition, YM administration increased the production of acetate, propionate, and total short-chain fatty acids.
33060635	2	1	theme	Bacteroides	344:354	arg1	abundance					373:381	Bacteroides thetaiotaomicron abundance	344:381	Bacteroides thetaiotaomicron abundance	344:381	We previously reported that YM increased Bacteroides thetaiotaomicron abundance in in vitro rat faeces fermentation, concluding that its effects on human colonic microbiota should be investigated.
33060635	6	2	theme	YM	1020:1021	arg1	administration					1023:1036	YM administration	1020:1036	YM administration	1020:1036	Moreover, a positive correlation was observed between the relative ratio (with or without YM administration) of B. thetaiotaomicron and B. ovatus (r = 0.92), suggesting that these bacteria utilise YM in a coordinated manner.
33060635	8	3	theme	YM	1313:1314	arg1	potential					1300:1308	the potential	1296:1308	the potential of YM as a novel prebiotic that selectively increases B. thetaiotaomicron and B. ovatus and improves the intestinal environment	1296:1436	These results demonstrate the potential of YM as a novel prebiotic that selectively increases B. thetaiotaomicron and B. ovatus and improves the intestinal environment.
33060635	7	4	theme	total	1239:1243	arg1	acids					1263:1267	total short-chain fatty acids	1239:1267	total short-chain fatty acids	1239:1267	In addition, YM administration increased the production of acetate, propionate, and total short-chain fatty acids.
33060635	3	5	from	effects	527:533	arg1	microbiota					558:567	human colonic microbiota	544:567	human colonic microbiota	544:567	In this study, we show the effects of YM on human colonic microbiota and its metabolites using an in vitro human faeces fermentation system.
33060635	3	5	from	effects	527:533	arg1	metabolites					577:587	its metabolites	573:587	its metabolites using an in vitro human faeces fermentation system	573:638	In this study, we show the effects of YM on human colonic microbiota and its metabolites using an in vitro human faeces fermentation system.
33060635	2	6	from	effects	440:446	arg1	microbiota					465:474	human colonic microbiota	451:474	human colonic microbiota	451:474	We previously reported that YM increased Bacteroides thetaiotaomicron abundance in in vitro rat faeces fermentation, concluding that its effects on human colonic microbiota should be investigated.
33060635	4	7	theme	Bacterial	641:649	arg1	rRNA					655:658	Bacterial 16S rRNA	641:658	Bacterial 16S rRNA gene sequence analysis	641:681	Bacterial 16S rRNA gene sequence analysis showed that YM administration did not change the microbial diversity or composition.
33060635	0	8	theme	Bacteroides	95:105	arg1	ovatus					107:112	Bacteroides ovatus	95:112	Bacteroides ovatus	95:112	Prebiotic effects of yeast mannan, which selectively promotes Bacteroides thetaiotaomicron and Bacteroides ovatus in a human colonic microbiota model.
33060635	5	9	theme	thetaiotaomicron	912:927	arg1	abundance					873:881	the relative abundance	860:881	the relative abundance of Bacteroides ovatus and B. thetaiotaomicron	860:927	Quantitative real-time PCR analysis revealed that YM administration significantly increased the relative abundance of Bacteroides ovatus and B. thetaiotaomicron.
33060635	1	10	theme	notable	248:254	arg1	effect					266:271	a notable prebiotic effect	246:271	a notable prebiotic effect on the intestinal microbiota	246:300	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	9	11	theme	functional	1524:1533	arg1	foods					1535:1539	novel functional foods	1518:1539	novel functional foods	1518:1539	The findings also provide insights that might be useful for the development of novel functional foods.
33060635	6	12	theme	B.	1066:1067	arg1	ratio					997:1001	the relative ratio	984:1001	the relative ratio (with or without YM administration) of B. thetaiotaomicron and B. ovatus (r = 0.92)	984:1085	Moreover, a positive correlation was observed between the relative ratio (with or without YM administration) of B. thetaiotaomicron and B. ovatus (r = 0.92), suggesting that these bacteria utilise YM in a coordinated manner.
33060635	4	13	theme	rRNA	655:658	arg1	analysis					674:681	Bacterial 16S rRNA gene sequence analysis	641:681	Bacterial 16S rRNA gene sequence analysis	641:681	Bacterial 16S rRNA gene sequence analysis showed that YM administration did not change the microbial diversity or composition.
33060635	2	14	theme	rat	395:397	arg1	fermentation					406:417	in vitro rat faeces fermentation	386:417	in vitro rat faeces fermentation	386:417	We previously reported that YM increased Bacteroides thetaiotaomicron abundance in in vitro rat faeces fermentation, concluding that its effects on human colonic microbiota should be investigated.
33060635	6	15	dep	B.	1066:1067	arg1	ovatus					1069:1074	B. ovatus	1066:1074	B. ovatus (r = 0.92)	1066:1085	Moreover, a positive correlation was observed between the relative ratio (with or without YM administration) of B. thetaiotaomicron and B. ovatus (r = 0.92), suggesting that these bacteria utilise YM in a coordinated manner.
33060635	7	16	theme	YM	1168:1169	arg1	administration					1171:1184	YM administration	1168:1184	YM administration	1168:1184	In addition, YM administration increased the production of acetate, propionate, and total short-chain fatty acids.
33060635	9	17	theme	foods	1535:1539	arg1	development					1503:1513	the development	1499:1513	the development of novel functional foods	1499:1539	The findings also provide insights that might be useful for the development of novel functional foods.
33060635	7	18	theme	propionate	1223:1232	arg1	production					1200:1209	the production	1196:1209	the production of acetate, propionate, and total short-chain fatty acids	1196:1267	In addition, YM administration increased the production of acetate, propionate, and total short-chain fatty acids.
33060635	3	19	theme	human	544:548	arg1	microbiota					558:567	human colonic microbiota	544:567	human colonic microbiota	544:567	In this study, we show the effects of YM on human colonic microbiota and its metabolites using an in vitro human faeces fermentation system.
33060635	2	20	theme	in	386:387	arg1	fermentation					406:417	in vitro rat faeces fermentation	386:417	in vitro rat faeces fermentation	386:417	We previously reported that YM increased Bacteroides thetaiotaomicron abundance in in vitro rat faeces fermentation, concluding that its effects on human colonic microbiota should be investigated.
33060635	0	21	theme	Prebiotic	0:8	arg1	effects					10:16	Prebiotic effects	0:16	Prebiotic effects of yeast mannan, which selectively promotes Bacteroides thetaiotaomicron and Bacteroides ovatus in a human colonic microbiota model.	0:149	Prebiotic effects of yeast mannan, which selectively promotes Bacteroides thetaiotaomicron and Bacteroides ovatus in a human colonic microbiota model.
33060635	1	22	theme	prebiotic	256:264	arg1	effect					266:271	a notable prebiotic effect	246:271	a notable prebiotic effect on the intestinal microbiota	246:300	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	1	23	from	effect	266:271	arg1	microbiota					291:300	the intestinal microbiota	276:300	the intestinal microbiota	276:300	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	3	24	theme	colonic	550:556	arg1	microbiota					558:567	human colonic microbiota	544:567	human colonic microbiota	544:567	In this study, we show the effects of YM on human colonic microbiota and its metabolites using an in vitro human faeces fermentation system.
33060635	4	25	theme	16S	651:653	arg1	rRNA					655:658	Bacterial 16S rRNA	641:658	Bacterial 16S rRNA gene sequence analysis	641:681	Bacterial 16S rRNA gene sequence analysis showed that YM administration did not change the microbial diversity or composition.
33060635	0	26	theme	yeast	21:25	arg1	mannan					27:32	yeast mannan	21:32	yeast mannan	21:32	Prebiotic effects of yeast mannan, which selectively promotes Bacteroides thetaiotaomicron and Bacteroides ovatus in a human colonic microbiota model.
33060635	1	27	with	polysaccharide	202:215	arg1	effect					266:271	a notable prebiotic effect	246:271	a notable prebiotic effect on the intestinal microbiota	246:300	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	3	28	theme	YM	538:539	arg1	effects					527:533	the effects	523:533	the effects of YM on human colonic microbiota and its metabolites using an in vitro human faeces fermentation system	523:638	In this study, we show the effects of YM on human colonic microbiota and its metabolites using an in vitro human faeces fermentation system.
33060635	1	29	theme	indigestible	175:186	arg1	mannan					157:162	Yeast mannan	151:162	Yeast mannan (YM)	151:167	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	1	29	theme	indigestible	175:186	arg1	polysaccharide					202:215	an indigestible water-soluble polysaccharide	172:215	an indigestible water-soluble polysaccharide of the yeast cell wall	172:238	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	6	30	theme	relative	988:995	arg1	ratio					997:1001	the relative ratio	984:1001	the relative ratio (with or without YM administration) of B. thetaiotaomicron and B. ovatus (r = 0.92)	984:1085	Moreover, a positive correlation was observed between the relative ratio (with or without YM administration) of B. thetaiotaomicron and B. ovatus (r = 0.92), suggesting that these bacteria utilise YM in a coordinated manner.
33060635	0	31	theme	human	119:123	arg1	model					144:148	a human colonic microbiota model	117:148	a human colonic microbiota model	117:148	Prebiotic effects of yeast mannan, which selectively promotes Bacteroides thetaiotaomicron and Bacteroides ovatus in a human colonic microbiota model.
33060635	3	32	theme	fermentation	620:631	arg1	system					633:638	an in vitro human faeces fermentation system	595:638	an in vitro human faeces fermentation system	595:638	In this study, we show the effects of YM on human colonic microbiota and its metabolites using an in vitro human faeces fermentation system.
33060635	6	33	theme	coordinated	1135:1145	arg1	manner					1147:1152	a coordinated manner	1133:1152	a coordinated manner	1133:1152	Moreover, a positive correlation was observed between the relative ratio (with or without YM administration) of B. thetaiotaomicron and B. ovatus (r = 0.92), suggesting that these bacteria utilise YM in a coordinated manner.
33060635	1	34	theme	water-soluble	188:200	arg1	mannan					157:162	Yeast mannan	151:162	Yeast mannan (YM)	151:167	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	1	34	theme	water-soluble	188:200	arg1	polysaccharide					202:215	an indigestible water-soluble polysaccharide	172:215	an indigestible water-soluble polysaccharide of the yeast cell wall	172:238	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	5	35	theme	Quantitative	768:779	arg1	analysis					795:802	Quantitative real-time PCR analysis	768:802	Quantitative real-time PCR analysis	768:802	Quantitative real-time PCR analysis revealed that YM administration significantly increased the relative abundance of Bacteroides ovatus and B. thetaiotaomicron.
33060635	7	36	theme	short-chain	1245:1255	arg1	acids					1263:1267	total short-chain fatty acids	1239:1267	total short-chain fatty acids	1239:1267	In addition, YM administration increased the production of acetate, propionate, and total short-chain fatty acids.
33060635	5	37	theme	ovatus	898:903	arg1	abundance					873:881	the relative abundance	860:881	the relative abundance of Bacteroides ovatus and B. thetaiotaomicron	860:927	Quantitative real-time PCR analysis revealed that YM administration significantly increased the relative abundance of Bacteroides ovatus and B. thetaiotaomicron.
33060635	3	38	dep	in	598:599	arg1	vitro					601:605	vitro	601:605	vitro	601:605	In this study, we show the effects of YM on human colonic microbiota and its metabolites using an in vitro human faeces fermentation system.
33060635	0	39	theme	mannan	27:32	arg1	effects					10:16	Prebiotic effects	0:16	Prebiotic effects of yeast mannan, which selectively promotes Bacteroides thetaiotaomicron and Bacteroides ovatus in a human colonic microbiota model.	0:149	Prebiotic effects of yeast mannan, which selectively promotes Bacteroides thetaiotaomicron and Bacteroides ovatus in a human colonic microbiota model.
33060635	1	40	theme	intestinal	280:289	arg1	microbiota					291:300	the intestinal microbiota	276:300	the intestinal microbiota	276:300	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	0	41	theme	microbiota	133:142	arg1	model					144:148	a human colonic microbiota model	117:148	a human colonic microbiota model	117:148	Prebiotic effects of yeast mannan, which selectively promotes Bacteroides thetaiotaomicron and Bacteroides ovatus in a human colonic microbiota model.
33060635	3	42	theme	human	607:611	arg1	system					633:638	an in vitro human faeces fermentation system	595:638	an in vitro human faeces fermentation system	595:638	In this study, we show the effects of YM on human colonic microbiota and its metabolites using an in vitro human faeces fermentation system.
33060635	5	43	theme	YM	818:819	arg1	administration					821:834	YM administration	818:834	YM administration	818:834	Quantitative real-time PCR analysis revealed that YM administration significantly increased the relative abundance of Bacteroides ovatus and B. thetaiotaomicron.
33060635	2	44	theme	faeces	399:404	arg1	fermentation					406:417	in vitro rat faeces fermentation	386:417	in vitro rat faeces fermentation	386:417	We previously reported that YM increased Bacteroides thetaiotaomicron abundance in in vitro rat faeces fermentation, concluding that its effects on human colonic microbiota should be investigated.
33060635	2	45	theme	colonic	457:463	arg1	microbiota					465:474	human colonic microbiota	451:474	human colonic microbiota	451:474	We previously reported that YM increased Bacteroides thetaiotaomicron abundance in in vitro rat faeces fermentation, concluding that its effects on human colonic microbiota should be investigated.
33060635	6	46	theme	thetaiotaomicron	1045:1060	arg1	ratio					997:1001	the relative ratio	984:1001	the relative ratio (with or without YM administration) of B. thetaiotaomicron and B. ovatus (r = 0.92)	984:1085	Moreover, a positive correlation was observed between the relative ratio (with or without YM administration) of B. thetaiotaomicron and B. ovatus (r = 0.92), suggesting that these bacteria utilise YM in a coordinated manner.
33060635	3	47	theme	faeces	613:618	arg1	system					633:638	an in vitro human faeces fermentation system	595:638	an in vitro human faeces fermentation system	595:638	In this study, we show the effects of YM on human colonic microbiota and its metabolites using an in vitro human faeces fermentation system.
33060635	4	48	theme	YM	695:696	arg1	administration					698:711	YM administration	695:711	YM administration	695:711	Bacterial 16S rRNA gene sequence analysis showed that YM administration did not change the microbial diversity or composition.
33060635	2	49	theme	human	451:455	arg1	microbiota					465:474	human colonic microbiota	451:474	human colonic microbiota	451:474	We previously reported that YM increased Bacteroides thetaiotaomicron abundance in in vitro rat faeces fermentation, concluding that its effects on human colonic microbiota should be investigated.
33060635	0	50	theme	colonic	125:131	arg1	model					144:148	a human colonic microbiota model	117:148	a human colonic microbiota model	117:148	Prebiotic effects of yeast mannan, which selectively promotes Bacteroides thetaiotaomicron and Bacteroides ovatus in a human colonic microbiota model.
33060635	7	51	theme	fatty	1257:1261	arg1	acids					1263:1267	total short-chain fatty acids	1239:1267	total short-chain fatty acids	1239:1267	In addition, YM administration increased the production of acetate, propionate, and total short-chain fatty acids.
33060635	3	52	theme	in	598:599	arg1	system					633:638	an in vitro human faeces fermentation system	595:638	an in vitro human faeces fermentation system	595:638	In this study, we show the effects of YM on human colonic microbiota and its metabolites using an in vitro human faeces fermentation system.
33060635	2	53	dep	in	386:387	arg1	vitro					389:393	vitro	389:393	vitro	389:393	We previously reported that YM increased Bacteroides thetaiotaomicron abundance in in vitro rat faeces fermentation, concluding that its effects on human colonic microbiota should be investigated.
33060635	4	54	theme	gene	660:663	arg1	analysis					674:681	Bacterial 16S rRNA gene sequence analysis	641:681	Bacterial 16S rRNA gene sequence analysis	641:681	Bacterial 16S rRNA gene sequence analysis showed that YM administration did not change the microbial diversity or composition.
33060635	7	55	theme	acids	1263:1267	arg1	production					1200:1209	the production	1196:1209	the production of acetate, propionate, and total short-chain fatty acids	1196:1267	In addition, YM administration increased the production of acetate, propionate, and total short-chain fatty acids.
33060635	4	56	theme	microbial	732:740	arg1	diversity					742:750	the microbial diversity	728:750	the microbial diversity	728:750	Bacterial 16S rRNA gene sequence analysis showed that YM administration did not change the microbial diversity or composition.
33060635	8	57	theme	intestinal	1415:1424	arg1	environment					1426:1436	the intestinal environment	1411:1436	the intestinal environment	1411:1436	These results demonstrate the potential of YM as a novel prebiotic that selectively increases B. thetaiotaomicron and B. ovatus and improves the intestinal environment.
33060635	2	58	theme	thetaiotaomicron	356:371	arg1	abundance					373:381	Bacteroides thetaiotaomicron abundance	344:381	Bacteroides thetaiotaomicron abundance	344:381	We previously reported that YM increased Bacteroides thetaiotaomicron abundance in in vitro rat faeces fermentation, concluding that its effects on human colonic microbiota should be investigated.
33060635	8	59	theme	novel	1321:1325	arg1	prebiotic					1327:1335	a novel prebiotic	1319:1335	a novel prebiotic that selectively increases B. thetaiotaomicron and B. ovatus and improves the intestinal environment	1319:1436	These results demonstrate the potential of YM as a novel prebiotic that selectively increases B. thetaiotaomicron and B. ovatus and improves the intestinal environment.
33060635	1	60	theme	yeast	224:228	arg1	wall					235:238	the yeast cell wall	220:238	the yeast cell wall	220:238	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	0	61	theme	Bacteroides	62:72	arg1	thetaiotaomicron					74:89	Bacteroides thetaiotaomicron	62:89	Bacteroides thetaiotaomicron	62:89	Prebiotic effects of yeast mannan, which selectively promotes Bacteroides thetaiotaomicron and Bacteroides ovatus in a human colonic microbiota model.
33060635	5	62	theme	relative	864:871	arg1	abundance					873:881	the relative abundance	860:881	the relative abundance of Bacteroides ovatus and B. thetaiotaomicron	860:927	Quantitative real-time PCR analysis revealed that YM administration significantly increased the relative abundance of Bacteroides ovatus and B. thetaiotaomicron.
33060635	9	63	theme	novel	1518:1522	arg1	foods					1535:1539	novel functional foods	1518:1539	novel functional foods	1518:1539	The findings also provide insights that might be useful for the development of novel functional foods.
33060635	4	64	theme	sequence	665:672	arg1	analysis					674:681	Bacterial 16S rRNA gene sequence analysis	641:681	Bacterial 16S rRNA gene sequence analysis	641:681	Bacterial 16S rRNA gene sequence analysis showed that YM administration did not change the microbial diversity or composition.
33060635	1	65	theme	cell	230:233	arg1	wall					235:238	the yeast cell wall	220:238	the yeast cell wall	220:238	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	5	66	theme	PCR	791:793	arg1	analysis					795:802	Quantitative real-time PCR analysis	768:802	Quantitative real-time PCR analysis	768:802	Quantitative real-time PCR analysis revealed that YM administration significantly increased the relative abundance of Bacteroides ovatus and B. thetaiotaomicron.
33060635	6	67	theme	positive	942:949	arg1	correlation					951:961	a positive correlation	940:961	a positive correlation	940:961	Moreover, a positive correlation was observed between the relative ratio (with or without YM administration) of B. thetaiotaomicron and B. ovatus (r = 0.92), suggesting that these bacteria utilise YM in a coordinated manner.
33060635	5	68	theme	real-time	781:789	arg1	analysis					795:802	Quantitative real-time PCR analysis	768:802	Quantitative real-time PCR analysis	768:802	Quantitative real-time PCR analysis revealed that YM administration significantly increased the relative abundance of Bacteroides ovatus and B. thetaiotaomicron.
33060635	1	69	theme	Yeast	151:155	arg1	polysaccharide					202:215	an indigestible water-soluble polysaccharide	172:215	an indigestible water-soluble polysaccharide of the yeast cell wall	172:238	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	1	69	theme	Yeast	151:155	arg1	YM					165:166	YM	165:166	YM	165:166	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	1	69	theme	Yeast	151:155	arg1	mannan					157:162	Yeast mannan	151:162	Yeast mannan (YM)	151:167	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	1	70	theme	wall	235:238	arg1	mannan					157:162	Yeast mannan	151:162	Yeast mannan (YM)	151:167	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
33060635	1	70	theme	wall	235:238	arg1	polysaccharide					202:215	an indigestible water-soluble polysaccharide	172:215	an indigestible water-soluble polysaccharide of the yeast cell wall	172:238	Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on the intestinal microbiota.
32535201	0	0	from	antioxidant	18:28	arg1	presence					69:76	presence	69:76	presence of citric acid esterified cellulose nanocrystals	69:125	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	6	1	theme	UV	1097:1098	arg1	behaviour					1111:1119	no UV resistance behaviour	1094:1119	no UV resistance behaviour	1094:1119	Interestingly, PVA/mCNC composite films showed a clear UV shielding effect, while no UV resistance behaviour was detected for PVA/CNC films.
32535201	6	2	theme	resistance	1100:1109	arg1	behaviour					1111:1119	no UV resistance behaviour	1094:1119	no UV resistance behaviour	1094:1119	Interestingly, PVA/mCNC composite films showed a clear UV shielding effect, while no UV resistance behaviour was detected for PVA/CNC films.
32535201	2	3	theme	cellulose	267:275	arg1	CNC					291:293	CNC	291:293	CNC	291:293	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	2	3	theme	cellulose	267:275	arg1	nanocrystals					277:288	unmodified cellulose nanocrystals	256:288	unmodified cellulose nanocrystals (CNC)	256:294	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	7	4	theme	migration	1161:1169	arg1	tests					1171:1175	Overall migration tests	1153:1175	Overall migration tests	1153:1175	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	6	5	theme	shielding	1070:1078	arg1	effect					1080:1085	a clear UV shielding effect	1059:1085	a clear UV shielding effect	1059:1085	Interestingly, PVA/mCNC composite films showed a clear UV shielding effect, while no UV resistance behaviour was detected for PVA/CNC films.
32535201	1	6	theme	different	209:217	arg1	wt					248:249	1, 3, 5, 10 and 15% wt.	228:250	1, 3, 5, 10 and 15% wt.	228:250	In the present work, poly(vinyl alcohol) (PVA) active packaging films containing different amounts (1, 3, 5, 10 and 15% wt.)
32535201	1	6	theme	different	209:217	arg1	amounts					219:225	different amounts	209:225	different amounts (1, 3, 5, 10 and 15% wt.)	209:251	In the present work, poly(vinyl alcohol) (PVA) active packaging films containing different amounts (1, 3, 5, 10 and 15% wt.)
32535201	3	7	theme	matrix	575:580	arg1	stability					549:557	the thermal stability	537:557	the thermal stability of the neat PVA matrix	537:580	Results showed that both CNC and mCNC improved the thermal stability of the neat PVA matrix, but different mechanical properties and water wettability were found.
32535201	6	8	theme	UV	1067:1068	arg1	effect					1080:1085	a clear UV shielding effect	1059:1085	a clear UV shielding effect	1059:1085	Interestingly, PVA/mCNC composite films showed a clear UV shielding effect, while no UV resistance behaviour was detected for PVA/CNC films.
32535201	1	9	theme	poly	149:152	arg1	films					192:196	poly(vinyl alcohol) (PVA) active packaging films	149:196	poly(vinyl alcohol) (PVA) active packaging films	149:196	In the present work, poly(vinyl alcohol) (PVA) active packaging films containing different amounts (1, 3, 5, 10 and 15% wt.)
32535201	7	10	contain	have	1315:1318	arg1	films					1309:1313	PVA/mCNC composite films	1290:1313	PVA/mCNC composite films	1290:1313	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	7	10	contain	have	1315:1318	arg2	activity					1346:1353	higher radical scavenging activity	1320:1353	higher radical scavenging activity than PVA/CNC films	1320:1372	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	0	11	theme	acid	88:91	arg1	presence					69:76	presence	69:76	presence of citric acid esterified cellulose nanocrystals	69:125	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	0	12	from	Thermomechanical	0:15	arg1	presence					69:76	presence	69:76	presence of citric acid esterified cellulose nanocrystals	69:125	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	0	13	theme	citric	81:86	arg1	acid					88:91	citric acid	81:91	citric acid esterified cellulose nanocrystals	81:125	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	0	13	theme	citric	81:86	arg1	nanocrystals					114:125	nanocrystals	114:125	nanocrystals	114:125	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	0	13	theme	citric	81:86	arg1	cellulose					104:112	cellulose	104:112	cellulose	104:112	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	7	14	theme	food	1266:1269	arg1	materials					1279:1287	food contact materials	1266:1287	food contact materials	1266:1287	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	4	15	theme	Thermal	653:659	arg1	stability					661:669	Thermal stability	653:669	Thermal stability of the materials	653:686	Thermal stability of the materials was enhanced, by measuring shift of onset and peak temperatures that moved, respectively, from 251.5 to 298.1 °C and from 283.4 to 374.2 °C, in the case of PVA/15CNC and PVA/15mCNC films.
32535201	0	16	dep	esterified	93:102	arg1	acid					88:91	citric acid	81:91	citric acid esterified cellulose nanocrystals	81:125	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	0	16	dep	esterified	93:102	arg1	nanocrystals					114:125	nanocrystals	114:125	nanocrystals	114:125	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	0	16	dep	esterified	93:102	arg1	cellulose					104:112	cellulose	104:112	cellulose	104:112	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	8	17	theme	active	1518:1523	arg1	films					1472:1476	PVA/mCNC films	1463:1476	PVA/mCNC films	1463:1476	In conclusion, PVA/mCNC films could be considered as high-performance active food packaging materials.
32535201	8	17	theme	active	1518:1523	arg1	materials					1540:1548	high-performance active food packaging materials	1501:1548	high-performance active food packaging materials	1501:1548	In conclusion, PVA/mCNC films could be considered as high-performance active food packaging materials.
32535201	8	18	theme	food	1525:1528	arg1	films					1472:1476	PVA/mCNC films	1463:1476	PVA/mCNC films	1463:1476	In conclusion, PVA/mCNC films could be considered as high-performance active food packaging materials.
32535201	8	18	theme	food	1525:1528	arg1	materials					1540:1548	high-performance active food packaging materials	1501:1548	high-performance active food packaging materials	1501:1548	In conclusion, PVA/mCNC films could be considered as high-performance active food packaging materials.
32535201	3	19	theme	water	623:627	arg1	wettability					629:639	water wettability	623:639	water wettability	623:639	Results showed that both CNC and mCNC improved the thermal stability of the neat PVA matrix, but different mechanical properties and water wettability were found.
32535201	7	20	theme	legislative	1230:1240	arg1	limits					1242:1247	the legislative limits	1226:1247	the legislative limits (60 mg kg-1) for food contact materials	1226:1287	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	7	20	theme	legislative	1230:1240	arg1	60 mg kg-1					1250:1259	60 mg kg-1	1250:1259	60 mg kg-1	1250:1259	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	8	21	theme	high-performance	1501:1516	arg1	films					1472:1476	PVA/mCNC films	1463:1476	PVA/mCNC films	1463:1476	In conclusion, PVA/mCNC films could be considered as high-performance active food packaging materials.
32535201	8	21	theme	high-performance	1501:1516	arg1	materials					1540:1548	high-performance active food packaging materials	1501:1548	high-performance active food packaging materials	1501:1548	In conclusion, PVA/mCNC films could be considered as high-performance active food packaging materials.
32535201	2	22	theme	citric	300:305	arg1	acid					307:310	citric acid	300:310	citric acid	300:310	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	2	23	theme	thermal	404:410	arg1	behaviour					440:448	thermal, mechanical and wettability behaviour	404:448	thermal, mechanical and wettability behaviour	404:448	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	3	24	theme	mechanical	597:606	arg1	properties					608:617	different mechanical properties	587:617	different mechanical properties	587:617	Results showed that both CNC and mCNC improved the thermal stability of the neat PVA matrix, but different mechanical properties and water wettability were found.
32535201	4	25	theme	onset	724:728	arg1	shift					715:719	shift	715:719	shift of onset and peak temperatures that moved, respectively, from 251.5 to 298.1 °C and from 283.4 to 374.2 °C, in the case of PVA/15CNC and PVA/15mCNC films	715:873	Thermal stability of the materials was enhanced, by measuring shift of onset and peak temperatures that moved, respectively, from 251.5 to 298.1 °C and from 283.4 to 374.2 °C, in the case of PVA/15CNC and PVA/15mCNC films.
32535201	7	26	theme	moisture	1378:1385	arg1	content					1387:1393	moisture content	1378:1393	moisture content of PVA films containing mCNC	1378:1422	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	8	27	theme	packaging	1530:1538	arg1	films					1472:1476	PVA/mCNC films	1463:1476	PVA/mCNC films	1463:1476	In conclusion, PVA/mCNC films could be considered as high-performance active food packaging materials.
32535201	8	27	theme	packaging	1530:1538	arg1	materials					1540:1548	high-performance active food packaging materials	1501:1548	high-performance active food packaging materials	1501:1548	In conclusion, PVA/mCNC films could be considered as high-performance active food packaging materials.
32535201	1	28	theme	vinyl	154:158	arg1	alcohol					160:166	vinyl alcohol	154:166	vinyl alcohol	154:166	In the present work, poly(vinyl alcohol) (PVA) active packaging films containing different amounts (1, 3, 5, 10 and 15% wt.)
32535201	1	28	theme	vinyl	154:158	arg1	poly					149:152	poly	149:152	poly(vinyl alcohol) (PVA) active packaging films	149:196	In the present work, poly(vinyl alcohol) (PVA) active packaging films containing different amounts (1, 3, 5, 10 and 15% wt.)
32535201	0	29	from	moisture	34:41	arg1	presence					69:76	presence	69:76	presence of citric acid esterified cellulose nanocrystals	69:125	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	4	30	theme	temperatures	739:750	arg1	shift					715:719	shift	715:719	shift of onset and peak temperatures that moved, respectively, from 251.5 to 298.1 °C and from 283.4 to 374.2 °C, in the case of PVA/15CNC and PVA/15mCNC films	715:873	Thermal stability of the materials was enhanced, by measuring shift of onset and peak temperatures that moved, respectively, from 251.5 to 298.1 °C and from 283.4 to 374.2 °C, in the case of PVA/15CNC and PVA/15mCNC films.
32535201	7	31	theme	contact	1271:1277	arg1	materials					1279:1287	food contact materials	1266:1287	food contact materials	1266:1287	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	4	32	theme	films	869:873	arg1	case					836:839	the case	832:839	the case of PVA/15CNC and PVA/15mCNC films	832:873	Thermal stability of the materials was enhanced, by measuring shift of onset and peak temperatures that moved, respectively, from 251.5 to 298.1 °C and from 283.4 to 374.2 °C, in the case of PVA/15CNC and PVA/15mCNC films.
32535201	4	33	theme	peak	734:737	arg1	temperatures					739:750	peak temperatures	734:750	peak temperatures	734:750	Thermal stability of the materials was enhanced, by measuring shift of onset and peak temperatures that moved, respectively, from 251.5 to 298.1 °C and from 283.4 to 374.2 °C, in the case of PVA/15CNC and PVA/15mCNC films.
32535201	4	34	theme	PVA/15mCNC	858:867	arg1	films					869:873	PVA/15mCNC films	858:873	PVA/15mCNC films	858:873	Thermal stability of the materials was enhanced, by measuring shift of onset and peak temperatures that moved, respectively, from 251.5 to 298.1 °C and from 283.4 to 374.2 °C, in the case of PVA/15CNC and PVA/15mCNC films.
32535201	7	35	theme	higher	1320:1325	arg1	activity					1346:1353	higher radical scavenging activity	1320:1353	higher radical scavenging activity than PVA/CNC films	1320:1372	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	7	36	theme	Overall	1153:1159	arg1	tests					1171:1175	Overall migration tests	1153:1175	Overall migration tests	1153:1175	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	6	37	theme	composite	1036:1044	arg1	films					1046:1050	PVA/mCNC composite films	1027:1050	PVA/mCNC composite films	1027:1050	Interestingly, PVA/mCNC composite films showed a clear UV shielding effect, while no UV resistance behaviour was detected for PVA/CNC films.
32535201	7	38	theme	high	1439:1442	arg1	RH					1444:1445	high RH	1439:1445	high RH	1439:1445	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	4	39	dep	374.2	819:823	arg1	to					816:817	to	816:817	to	816:817	Thermal stability of the materials was enhanced, by measuring shift of onset and peak temperatures that moved, respectively, from 251.5 to 298.1 °C and from 283.4 to 374.2 °C, in the case of PVA/15CNC and PVA/15mCNC films.
32535201	3	40	theme	thermal	541:547	arg1	stability					549:557	the thermal stability	537:557	the thermal stability of the neat PVA matrix	537:580	Results showed that both CNC and mCNC improved the thermal stability of the neat PVA matrix, but different mechanical properties and water wettability were found.
32535201	2	41	theme	unmodified	256:265	arg1	CNC					291:293	CNC	291:293	CNC	291:293	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	2	41	theme	unmodified	256:265	arg1	nanocrystals					277:288	unmodified cellulose nanocrystals	256:288	unmodified cellulose nanocrystals (CNC)	256:294	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	2	42	theme	cellulose	321:329	arg1	mCNC					345:348	mCNC	345:348	mCNC	345:348	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	2	42	theme	cellulose	321:329	arg1	nanocrystals					331:342	modified cellulose nanocrystals	312:342	modified cellulose nanocrystals (mCNC)	312:349	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	4	43	theme	PVA/15CNC	844:852	arg1	case					836:839	the case	832:839	the case of PVA/15CNC and PVA/15mCNC films	832:873	Thermal stability of the materials was enhanced, by measuring shift of onset and peak temperatures that moved, respectively, from 251.5 to 298.1 °C and from 283.4 to 374.2 °C, in the case of PVA/15CNC and PVA/15mCNC films.
32535201	6	44	theme	PVA/CNC	1138:1144	arg1	films					1146:1150	PVA/CNC films	1138:1150	PVA/CNC films	1138:1150	Interestingly, PVA/mCNC composite films showed a clear UV shielding effect, while no UV resistance behaviour was detected for PVA/CNC films.
32535201	7	45	theme	PVA/CNC	1360:1366	arg1	films					1368:1372	PVA/CNC films	1360:1372	PVA/CNC films	1360:1372	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	7	46	theme	migration	1195:1203	arg1	value					1205:1209	the migration value	1191:1209	the migration value	1191:1209	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	7	47	theme	radical	1327:1333	arg1	activity					1346:1353	higher radical scavenging activity	1320:1353	higher radical scavenging activity than PVA/CNC films	1320:1372	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	2	48	theme	modified	312:319	arg1	mCNC					345:348	mCNC	345:348	mCNC	345:348	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	2	48	theme	modified	312:319	arg1	nanocrystals					331:342	modified cellulose nanocrystals	312:342	modified cellulose nanocrystals (mCNC)	312:349	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	2	49	theme	solvent	368:374	arg1	casting					376:382	solvent casting	368:382	solvent casting	368:382	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	2	50	theme	wettability	428:438	arg1	behaviour					440:448	thermal, mechanical and wettability behaviour	404:448	thermal, mechanical and wettability behaviour	404:448	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	7	51	theme	scavenging	1335:1344	arg1	activity					1346:1353	higher radical scavenging activity	1320:1353	higher radical scavenging activity than PVA/CNC films	1320:1372	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	1	52	theme	active	175:180	arg1	films					192:196	poly(vinyl alcohol) (PVA) active packaging films	149:196	poly(vinyl alcohol) (PVA) active packaging films	149:196	In the present work, poly(vinyl alcohol) (PVA) active packaging films containing different amounts (1, 3, 5, 10 and 15% wt.)
32535201	0	53	theme	PVA	56:58	arg1	films					60:64	PVA films	56:64	PVA films	56:64	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	2	54	from	effect	394:399	arg1	behaviour					440:448	thermal, mechanical and wettability behaviour	404:448	thermal, mechanical and wettability behaviour	404:448	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	6	55	theme	clear	1061:1065	arg1	effect					1080:1085	a clear UV shielding effect	1059:1085	a clear UV shielding effect	1059:1085	Interestingly, PVA/mCNC composite films showed a clear UV shielding effect, while no UV resistance behaviour was detected for PVA/CNC films.
32535201	7	56	theme	PVA/mCNC	1290:1297	arg1	films					1309:1313	PVA/mCNC composite films	1290:1313	PVA/mCNC composite films	1290:1313	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	3	57	theme	neat	566:569	arg1	matrix					575:580	the neat PVA matrix	562:580	the neat PVA matrix	562:580	Results showed that both CNC and mCNC improved the thermal stability of the neat PVA matrix, but different mechanical properties and water wettability were found.
32535201	5	58	theme	mCNC	892:895	arg1	presence					880:887	The presence	876:887	The presence of mCNC	876:895	The presence of mCNC contribute to increase the crystallinity up to 52% for PVA/10mCNC film, while it was limited to 39% for PVA/10CNC.
32535201	1	59	theme	%	246:246	arg1	wt					248:249	1, 3, 5, 10 and 15% wt.	228:250	1, 3, 5, 10 and 15% wt.	228:250	In the present work, poly(vinyl alcohol) (PVA) active packaging films containing different amounts (1, 3, 5, 10 and 15% wt.)
32535201	1	59	theme	%	246:246	arg1	amounts					219:225	different amounts	209:225	different amounts (1, 3, 5, 10 and 15% wt.)	209:251	In the present work, poly(vinyl alcohol) (PVA) active packaging films containing different amounts (1, 3, 5, 10 and 15% wt.)
32535201	2	60	theme	films	466:470	arg1	effect					394:399	their effect	388:399	their effect on thermal, mechanical and wettability behaviour of the resulted films	388:470	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	3	61	theme	PVA	571:573	arg1	matrix					575:580	the neat PVA matrix	562:580	the neat PVA matrix	562:580	Results showed that both CNC and mCNC improved the thermal stability of the neat PVA matrix, but different mechanical properties and water wettability were found.
32535201	6	62	theme	PVA/mCNC	1027:1034	arg1	films					1046:1050	PVA/mCNC composite films	1027:1050	PVA/mCNC composite films	1027:1050	Interestingly, PVA/mCNC composite films showed a clear UV shielding effect, while no UV resistance behaviour was detected for PVA/CNC films.
32535201	4	63	dep	298.1	792:796	arg1	to					789:790	to	789:790	to	789:790	Thermal stability of the materials was enhanced, by measuring shift of onset and peak temperatures that moved, respectively, from 251.5 to 298.1 °C and from 283.4 to 374.2 °C, in the case of PVA/15CNC and PVA/15mCNC films.
32535201	1	64	theme	packaging	182:190	arg1	films					192:196	poly(vinyl alcohol) (PVA) active packaging films	149:196	poly(vinyl alcohol) (PVA) active packaging films	149:196	In the present work, poly(vinyl alcohol) (PVA) active packaging films containing different amounts (1, 3, 5, 10 and 15% wt.)
32535201	2	65	theme	resulted	457:464	arg1	films					466:470	the resulted films	453:470	the resulted films	453:470	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
32535201	4	66	theme	materials	678:686	arg1	stability					661:669	Thermal stability	653:669	Thermal stability of the materials	653:686	Thermal stability of the materials was enhanced, by measuring shift of onset and peak temperatures that moved, respectively, from 251.5 to 298.1 °C and from 283.4 to 374.2 °C, in the case of PVA/15CNC and PVA/15mCNC films.
32535201	7	67	theme	composite	1299:1307	arg1	films					1309:1313	PVA/mCNC composite films	1290:1313	PVA/mCNC composite films	1290:1313	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	7	68	contain	containing	1408:1417	arg2	mCNC					1419:1422	mCNC	1419:1422	mCNC	1419:1422	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	7	68	contain	containing	1408:1417	arg1	films					1402:1406	PVA films	1398:1406	PVA films containing mCNC	1398:1422	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	7	69	theme	PVA	1398:1400	arg1	films					1402:1406	PVA films	1398:1406	PVA films containing mCNC	1398:1422	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	1	70	theme	present	135:141	arg1	work					143:146	the present work	131:146	the present work	131:146	In the present work, poly(vinyl alcohol) (PVA) active packaging films containing different amounts (1, 3, 5, 10 and 15% wt.)
32535201	8	71	theme	PVA/mCNC	1463:1470	arg1	films					1472:1476	PVA/mCNC films	1463:1476	PVA/mCNC films	1463:1476	In conclusion, PVA/mCNC films could be considered as high-performance active food packaging materials.
32535201	8	71	theme	PVA/mCNC	1463:1470	arg1	materials					1540:1548	high-performance active food packaging materials	1501:1548	high-performance active food packaging materials	1501:1548	In conclusion, PVA/mCNC films could be considered as high-performance active food packaging materials.
32535201	0	72	theme	films	60:64	arg1	antioxidant					18:28	antioxidant	18:28	antioxidant	18:28	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	0	72	theme	films	60:64	arg1	Thermomechanical					0:15	Thermomechanical	0:15	Thermomechanical	0:15	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	0	72	theme	films	60:64	arg1	moisture					34:41	moisture	34:41	moisture	34:41	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	5	73	theme	PVA/10mCNC	952:961	arg1	film					963:966	PVA/10mCNC film	952:966	PVA/10mCNC film	952:966	The presence of mCNC contribute to increase the crystallinity up to 52% for PVA/10mCNC film, while it was limited to 39% for PVA/10CNC.
32535201	0	74	dep	Thermomechanical	0:15	arg1	behaviour					43:51	behaviour	43:51	behaviour	43:51	Thermomechanical, antioxidant and moisture behaviour of PVA films in presence of citric acid esterified cellulose nanocrystals.
32535201	3	75	theme	different	587:595	arg1	properties					608:617	different mechanical properties	587:617	different mechanical properties	587:617	Results showed that both CNC and mCNC improved the thermal stability of the neat PVA matrix, but different mechanical properties and water wettability were found.
32535201	7	76	theme	films	1402:1406	arg1	content					1387:1393	moisture content	1378:1393	moisture content of PVA films containing mCNC	1378:1422	Overall migration tests revealed that the migration value was well below the legislative limits (60 mg kg-1) for food contact materials, PVA/mCNC composite films have higher radical scavenging activity than PVA/CNC films and moisture content of PVA films containing mCNC was reduced at high RH.
32535201	2	77	theme	mechanical	413:422	arg1	behaviour					440:448	thermal, mechanical and wettability behaviour	404:448	thermal, mechanical and wettability behaviour	404:448	of unmodified cellulose nanocrystals (CNC) and citric acid modified cellulose nanocrystals (mCNC) were prepared by solvent casting and their effect on thermal, mechanical and wettability behaviour of the resulted films was investigated.
34663844	10	0	theme	intestinal	1557:1566	arg1	flora					1568:1572	intestinal flora	1557:1572	intestinal flora	1557:1572	Importantly, 16S rDNA analysis indicated the AMP treatment significantly retarded the aging process by improving the composition of intestinal flora and abundance of beneficial bacteria.
34663844	7	1	theme	structural	1088:1097	arg1	disorders					1099:1107	structural disorders	1088:1107	structural disorders	1088:1107	H&E staining showed that AMP significantly reversed brain tissue pathological damage and structural disorders.
34663844	2	2	theme	main	337:340	arg1	component					342:350	the main component	333:350	the main component of the Aronia melanocarpa fruit	333:382	Aronia melanocarpa polysaccharide (AMP) is the main component of the Aronia melanocarpa fruit.
34663844	2	2	theme	main	337:340	arg1	polysaccharide					309:322	Aronia melanocarpa polysaccharide	290:322	Aronia melanocarpa polysaccharide (AMP)	290:328	Aronia melanocarpa polysaccharide (AMP) is the main component of the Aronia melanocarpa fruit.
34663844	10	3	theme	bacteria	1602:1609	arg1	abundance					1578:1586	abundance	1578:1586	abundance of beneficial bacteria	1578:1609	Importantly, 16S rDNA analysis indicated the AMP treatment significantly retarded the aging process by improving the composition of intestinal flora and abundance of beneficial bacteria.
34663844	10	3	theme	bacteria	1602:1609	arg1	composition					1542:1552	the composition	1538:1552	the composition of intestinal flora	1538:1572	Importantly, 16S rDNA analysis indicated the AMP treatment significantly retarded the aging process by improving the composition of intestinal flora and abundance of beneficial bacteria.
34663844	7	4	theme	tissue	1057:1062	arg1	damage					1077:1082	brain tissue pathological damage	1051:1082	brain tissue pathological damage	1051:1082	H&E staining showed that AMP significantly reversed brain tissue pathological damage and structural disorders.
34663844	10	5	theme	16S	1438:1440	arg1	analysis					1447:1454	16S rDNA analysis	1438:1454	16S rDNA analysis	1438:1454	Importantly, 16S rDNA analysis indicated the AMP treatment significantly retarded the aging process by improving the composition of intestinal flora and abundance of beneficial bacteria.
34663844	8	6	theme	signaling	1237:1245	arg1	pathways					1247:1254	Nrf2/HO-1 signaling pathways	1227:1254	Nrf2/HO-1 signaling pathways	1227:1254	AMP alleviated inflammation and oxidative stress injury in aging brain tissue by regulating the AMPK/SIRT1/NF-κB and Nrf2/HO-1 signaling pathways.
34663844	11	7	theme	metabolic	1829:1837	arg1	diseases					1839:1846	related metabolic diseases	1821:1846	related metabolic diseases	1821:1846	In summary, this study found that AMP delayed brain aging in mice by inhibiting inflammation and regulating intestinal microbes, which providing the possibility for the amelioration and treatment of aging and related metabolic diseases.
34663844	8	8	theme	brain	1175:1179	arg1	tissue					1181:1186	aging brain tissue	1169:1186	aging brain tissue	1169:1186	AMP alleviated inflammation and oxidative stress injury in aging brain tissue by regulating the AMPK/SIRT1/NF-κB and Nrf2/HO-1 signaling pathways.
34663844	0	9	theme	gut	134:136	arg1	microbiota					138:147	gut microbiota	134:147	gut microbiota	134:147	Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
34663844	2	10	theme	Aronia	290:295	arg1	component					342:350	the main component	333:350	the main component of the Aronia melanocarpa fruit	333:382	Aronia melanocarpa polysaccharide (AMP) is the main component of the Aronia melanocarpa fruit.
34663844	2	10	theme	Aronia	290:295	arg1	AMP					325:327	AMP	325:327	AMP	325:327	Aronia melanocarpa polysaccharide (AMP) is the main component of the Aronia melanocarpa fruit.
34663844	2	10	theme	Aronia	290:295	arg1	polysaccharide					309:322	Aronia melanocarpa polysaccharide	290:322	Aronia melanocarpa polysaccharide (AMP)	290:328	Aronia melanocarpa polysaccharide (AMP) is the main component of the Aronia melanocarpa fruit.
34663844	6	11	theme	spatial	907:913	arg1	learning					915:922	spatial learning	907:922	spatial learning	907:922	The results showed that AMP treatment significantly improved the spatial learning and memory impairment of aging mice determined by the eight-arm maze test.
34663844	1	12	theme	biological	220:229	arg1	activities					231:240	biological activities	220:240	biological activities	220:240	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	7	13	theme	H&E	999:1001	arg1	staining					1003:1010	H&E staining	999:1010	H&E staining	999:1010	H&E staining showed that AMP significantly reversed brain tissue pathological damage and structural disorders.
34663844	3	14	theme	AMP	568:570	arg1	effect					544:549	the effect	540:549	the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice	540:626	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	4	15	dep	1000 mg/kg	713:722	arg1	to					710:711	to	710:711	to	710:711	The aging model was established by intraperitoneal injection of D-Gal (200 mg/kg to 1000 mg/kg) once per 3 days for 12 weeks.
34663844	3	16	theme	intestinal	597:606	arg1	flora					608:612	the intestinal flora	593:612	the intestinal flora of aging mice	593:626	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	1	17	theme	Aronia	150:155	arg1	plant					192:196	a natural medicinal plant	172:196	a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine	172:287	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	1	17	theme	Aronia	150:155	arg1	melanocarpa					157:167	Aronia melanocarpa	150:167	Aronia melanocarpa	150:167	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	5	18	theme	D-Gal-induced	827:839	arg1	6 weeks					816:822	6 weeks	816:822	6 weeks of D-Gal-induced	816:839	AMP (100 and 200 mg/kg) was given daily by oral gavage after 6 weeks of D-Gal-induced.
34663844	4	19	theme	intraperitoneal	664:678	arg1	injection					680:688	intraperitoneal injection	664:688	intraperitoneal injection of D-Gal (200 mg/kg to 1000 mg/kg) once per 3 days for 12 weeks	664:752	The aging model was established by intraperitoneal injection of D-Gal (200 mg/kg to 1000 mg/kg) once per 3 days for 12 weeks.
34663844	9	20	theme	brain	1283:1287	arg1	apoptosis					1294:1302	brain cell apoptosis	1283:1302	brain cell apoptosis	1283:1302	Particularly, AMP reduced brain cell apoptosis and neurological deficits by activating the PI3K/AKT/mTOR signaling pathway and its downstream apoptotic protein family.
34663844	1	21	theme	natural	174:180	arg1	plant					192:196	a natural medicinal plant	172:196	a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine	172:287	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	1	21	theme	natural	174:180	arg1	melanocarpa					157:167	Aronia melanocarpa	150:167	Aronia melanocarpa	150:167	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	11	22	theme	intestinal	1720:1729	arg1	microbes					1731:1738	intestinal microbes	1720:1738	intestinal microbes	1720:1738	In summary, this study found that AMP delayed brain aging in mice by inhibiting inflammation and regulating intestinal microbes, which providing the possibility for the amelioration and treatment of aging and related metabolic diseases.
34663844	0	23	theme	AMPK/SIRT1/NF-κB	95:110	arg1	pathway					122:128	the AMPK/SIRT1/NF-κB signaling pathway	91:128	the AMPK/SIRT1/NF-κB signaling pathway	91:128	Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
34663844	0	24	from	aging	63:67	arg1	mice					72:75	mice	72:75	mice	72:75	Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
34663844	9	25	theme	neurological	1308:1319	arg1	deficits					1321:1328	neurological deficits	1308:1328	neurological deficits	1308:1328	Particularly, AMP reduced brain cell apoptosis and neurological deficits by activating the PI3K/AKT/mTOR signaling pathway and its downstream apoptotic protein family.
34663844	0	26	from	inflammation	46:57	arg1	mice					72:75	mice	72:75	mice	72:75	Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
34663844	2	27	theme	melanocarpa	366:376	arg1	fruit					378:382	the Aronia melanocarpa fruit	355:382	the Aronia melanocarpa fruit	355:382	Aronia melanocarpa polysaccharide (AMP) is the main component of the Aronia melanocarpa fruit.
34663844	0	28	theme	Aronia	0:5	arg1	polysaccharide					19:32	Aronia melanocarpa polysaccharide	0:32	Aronia melanocarpa polysaccharide	0:32	Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
34663844	10	29	theme	aging	1511:1515	arg1	process					1517:1523	the aging process	1507:1523	the aging process	1507:1523	Importantly, 16S rDNA analysis indicated the AMP treatment significantly retarded the aging process by improving the composition of intestinal flora and abundance of beneficial bacteria.
34663844	3	30	theme	mice	623:626	arg1	flora					608:612	the intestinal flora	593:612	the intestinal flora of aging mice	593:626	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	3	31	theme	AMP	437:439	arg1	protection					423:432	protection	423:432	protection	423:432	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	3	31	theme	AMP	437:439	arg1	delay					413:417	delay	413:417	delay	413:417	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	5	32	theme	oral	798:801	arg1	gavage					803:808	oral gavage	798:808	oral gavage	798:808	AMP (100 and 200 mg/kg) was given daily by oral gavage after 6 weeks of D-Gal-induced.
34663844	9	33	theme	signaling	1362:1370	arg1	pathway					1372:1378	the PI3K/AKT/mTOR signaling pathway	1344:1378	the PI3K/AKT/mTOR signaling pathway	1344:1378	Particularly, AMP reduced brain cell apoptosis and neurological deficits by activating the PI3K/AKT/mTOR signaling pathway and its downstream apoptotic protein family.
34663844	6	34	theme	maze	988:991	arg1	test					993:996	the eight-arm maze test	974:996	the eight-arm maze test	974:996	The results showed that AMP treatment significantly improved the spatial learning and memory impairment of aging mice determined by the eight-arm maze test.
34663844	11	35	from	aging	1664:1668	arg1	mice					1673:1676	mice	1673:1676	mice	1673:1676	In summary, this study found that AMP delayed brain aging in mice by inhibiting inflammation and regulating intestinal microbes, which providing the possibility for the amelioration and treatment of aging and related metabolic diseases.
34663844	8	36	from	stress	1152:1157	arg1	tissue					1181:1186	aging brain tissue	1169:1186	aging brain tissue	1169:1186	AMP alleviated inflammation and oxidative stress injury in aging brain tissue by regulating the AMPK/SIRT1/NF-κB and Nrf2/HO-1 signaling pathways.
34663844	3	37	theme	melanocarpa	462:472	arg1	fruit					474:478	Aronia melanocarpa fruit	455:478	Aronia melanocarpa fruit on aging mice	455:492	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	9	38	theme	downstream	1388:1397	arg1	family					1417:1422	its downstream apoptotic protein family	1384:1422	its downstream apoptotic protein family	1384:1422	Particularly, AMP reduced brain cell apoptosis and neurological deficits by activating the PI3K/AKT/mTOR signaling pathway and its downstream apoptotic protein family.
34663844	3	39	theme	D-Galactose	497:507	arg1	induction					517:525	D-Galactose (D-Gal) induction	497:525	D-Galactose (D-Gal) induction	497:525	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	9	40	theme	protein	1409:1415	arg1	family					1417:1422	its downstream apoptotic protein family	1384:1422	its downstream apoptotic protein family	1384:1422	Particularly, AMP reduced brain cell apoptosis and neurological deficits by activating the PI3K/AKT/mTOR signaling pathway and its downstream apoptotic protein family.
34663844	6	41	theme	AMP	866:868	arg1	treatment					870:878	AMP treatment	866:878	AMP treatment	866:878	The results showed that AMP treatment significantly improved the spatial learning and memory impairment of aging mice determined by the eight-arm maze test.
34663844	10	42	theme	flora	1568:1572	arg1	abundance					1578:1586	abundance	1578:1586	abundance of beneficial bacteria	1578:1609	Importantly, 16S rDNA analysis indicated the AMP treatment significantly retarded the aging process by improving the composition of intestinal flora and abundance of beneficial bacteria.
34663844	10	42	theme	flora	1568:1572	arg1	composition					1542:1552	the composition	1538:1552	the composition of intestinal flora	1538:1572	Importantly, 16S rDNA analysis indicated the AMP treatment significantly retarded the aging process by improving the composition of intestinal flora and abundance of beneficial bacteria.
34663844	11	43	theme	brain	1658:1662	arg1	aging					1664:1668	brain aging	1658:1668	brain aging in mice	1658:1676	In summary, this study found that AMP delayed brain aging in mice by inhibiting inflammation and regulating intestinal microbes, which providing the possibility for the amelioration and treatment of aging and related metabolic diseases.
34663844	7	44	theme	pathological	1064:1075	arg1	damage					1077:1082	brain tissue pathological damage	1051:1082	brain tissue pathological damage	1051:1082	H&E staining showed that AMP significantly reversed brain tissue pathological damage and structural disorders.
34663844	10	45	theme	beneficial	1591:1600	arg1	bacteria					1602:1609	beneficial bacteria	1591:1609	beneficial bacteria	1591:1609	Importantly, 16S rDNA analysis indicated the AMP treatment significantly retarded the aging process by improving the composition of intestinal flora and abundance of beneficial bacteria.
34663844	7	46	theme	brain	1051:1055	arg1	damage					1077:1082	brain tissue pathological damage	1051:1082	brain tissue pathological damage	1051:1082	H&E staining showed that AMP significantly reversed brain tissue pathological damage and structural disorders.
34663844	3	47	theme	D-Gal	510:514	arg1	induction					517:525	D-Galactose (D-Gal) induction	497:525	D-Galactose (D-Gal) induction	497:525	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	1	48	theme	medicinal	182:190	arg1	plant					192:196	a natural medicinal plant	172:196	a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine	172:287	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	1	48	theme	medicinal	182:190	arg1	melanocarpa					157:167	Aronia melanocarpa	150:167	Aronia melanocarpa	150:167	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	8	49	theme	oxidative	1142:1150	arg1	stress					1152:1157	oxidative stress	1142:1157	oxidative stress	1142:1157	AMP alleviated inflammation and oxidative stress injury in aging brain tissue by regulating the AMPK/SIRT1/NF-κB and Nrf2/HO-1 signaling pathways.
34663844	3	50	from	fruit	474:478	arg1	mice					489:492	aging mice	483:492	aging mice	483:492	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	6	51	theme	memory	928:933	arg1	impairment					935:944	the spatial learning and memory impairment	903:944	the spatial learning and memory impairment of aging mice determined by the eight-arm maze test	903:996	The results showed that AMP treatment significantly improved the spatial learning and memory impairment of aging mice determined by the eight-arm maze test.
34663844	8	52	theme	Nrf2/HO-1	1227:1235	arg1	pathways					1247:1254	Nrf2/HO-1 signaling pathways	1227:1254	Nrf2/HO-1 signaling pathways	1227:1254	AMP alleviated inflammation and oxidative stress injury in aging brain tissue by regulating the AMPK/SIRT1/NF-κB and Nrf2/HO-1 signaling pathways.
34663844	11	53	theme	diseases	1839:1846	arg1	treatment					1798:1806	treatment	1798:1806	treatment	1798:1806	In summary, this study found that AMP delayed brain aging in mice by inhibiting inflammation and regulating intestinal microbes, which providing the possibility for the amelioration and treatment of aging and related metabolic diseases.
34663844	11	53	theme	diseases	1839:1846	arg1	amelioration					1781:1792	amelioration	1781:1792	amelioration	1781:1792	In summary, this study found that AMP delayed brain aging in mice by inhibiting inflammation and regulating intestinal microbes, which providing the possibility for the amelioration and treatment of aging and related metabolic diseases.
34663844	2	54	theme	melanocarpa	297:307	arg1	component					342:350	the main component	333:350	the main component of the Aronia melanocarpa fruit	333:382	Aronia melanocarpa polysaccharide (AMP) is the main component of the Aronia melanocarpa fruit.
34663844	2	54	theme	melanocarpa	297:307	arg1	AMP					325:327	AMP	325:327	AMP	325:327	Aronia melanocarpa polysaccharide (AMP) is the main component of the Aronia melanocarpa fruit.
34663844	2	54	theme	melanocarpa	297:307	arg1	polysaccharide					309:322	Aronia melanocarpa polysaccharide	290:322	Aronia melanocarpa polysaccharide (AMP)	290:328	Aronia melanocarpa polysaccharide (AMP) is the main component of the Aronia melanocarpa fruit.
34663844	8	55	theme	aging	1169:1173	arg1	tissue					1181:1186	aging brain tissue	1169:1186	aging brain tissue	1169:1186	AMP alleviated inflammation and oxidative stress injury in aging brain tissue by regulating the AMPK/SIRT1/NF-κB and Nrf2/HO-1 signaling pathways.
34663844	6	56	theme	learning	915:922	arg1	impairment					935:944	the spatial learning and memory impairment	903:944	the spatial learning and memory impairment of aging mice determined by the eight-arm maze test	903:996	The results showed that AMP treatment significantly improved the spatial learning and memory impairment of aging mice determined by the eight-arm maze test.
34663844	3	57	theme	aging	483:487	arg1	mice					489:492	aging mice	483:492	aging mice	483:492	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	4	58	theme	aging	633:637	arg1	model					639:643	The aging model	629:643	The aging model	629:643	The aging model was established by intraperitoneal injection of D-Gal (200 mg/kg to 1000 mg/kg) once per 3 days for 12 weeks.
34663844	6	59	theme	aging	949:953	arg1	mice					955:958	aging mice	949:958	aging mice determined by the eight-arm maze test	949:996	The results showed that AMP treatment significantly improved the spatial learning and memory impairment of aging mice determined by the eight-arm maze test.
34663844	1	60	contain	has	203:205	arg2	activities					231:240	biological activities	220:240	biological activities	220:240	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	1	60	contain	has	203:205	arg2	variety					209:215	a variety	207:215	a variety of biological activities, its fruit is often used for food and medicine	207:287	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	1	60	contain	has	203:205	arg1	plant					192:196	a natural medicinal plant	172:196	a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine	172:287	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	1	60	contain	has	203:205	arg1	melanocarpa					157:167	Aronia melanocarpa	150:167	Aronia melanocarpa	150:167	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	11	61	dep	amelioration	1781:1792	arg1	the					1777:1779	the	1777:1779	the	1777:1779	In summary, this study found that AMP delayed brain aging in mice by inhibiting inflammation and regulating intestinal microbes, which providing the possibility for the amelioration and treatment of aging and related metabolic diseases.
34663844	3	62	theme	supplementing	554:566	arg1	AMP					568:570	supplementing AMP	554:570	supplementing AMP	554:570	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	6	63	theme	eight-arm	978:986	arg1	test					993:996	the eight-arm maze test	974:996	the eight-arm maze test	974:996	The results showed that AMP treatment significantly improved the spatial learning and memory impairment of aging mice determined by the eight-arm maze test.
34663844	4	64	theme	D-Gal	693:697	arg1	injection					680:688	intraperitoneal injection	664:688	intraperitoneal injection of D-Gal (200 mg/kg to 1000 mg/kg) once per 3 days for 12 weeks	664:752	The aging model was established by intraperitoneal injection of D-Gal (200 mg/kg to 1000 mg/kg) once per 3 days for 12 weeks.
34663844	3	65	from	effect	544:549	arg1	metabolism					579:588	the metabolism	575:588	the metabolism of the intestinal flora of aging mice	575:626	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	1	66	theme	activities	231:240	arg1	variety					209:215	a variety	207:215	a variety of biological activities, its fruit is often used for food and medicine	207:287	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	1	66	theme	activities	231:240	arg1	activities					231:240	biological activities	220:240	biological activities	220:240	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	6	67	theme	mice	955:958	arg1	impairment					935:944	the spatial learning and memory impairment	903:944	the spatial learning and memory impairment of aging mice determined by the eight-arm maze test	903:996	The results showed that AMP treatment significantly improved the spatial learning and memory impairment of aging mice determined by the eight-arm maze test.
34663844	10	68	theme	rDNA	1442:1445	arg1	analysis					1447:1454	16S rDNA analysis	1438:1454	16S rDNA analysis	1438:1454	Importantly, 16S rDNA analysis indicated the AMP treatment significantly retarded the aging process by improving the composition of intestinal flora and abundance of beneficial bacteria.
34663844	11	69	theme	aging	1811:1815	arg1	treatment					1798:1806	treatment	1798:1806	treatment	1798:1806	In summary, this study found that AMP delayed brain aging in mice by inhibiting inflammation and regulating intestinal microbes, which providing the possibility for the amelioration and treatment of aging and related metabolic diseases.
34663844	11	69	theme	aging	1811:1815	arg1	amelioration					1781:1792	amelioration	1781:1792	amelioration	1781:1792	In summary, this study found that AMP delayed brain aging in mice by inhibiting inflammation and regulating intestinal microbes, which providing the possibility for the amelioration and treatment of aging and related metabolic diseases.
34663844	0	70	theme	signaling	112:120	arg1	pathway					122:128	the AMPK/SIRT1/NF-κB signaling pathway	91:128	the AMPK/SIRT1/NF-κB signaling pathway	91:128	Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
34663844	9	71	theme	cell	1289:1292	arg1	apoptosis					1294:1302	brain cell apoptosis	1283:1302	brain cell apoptosis	1283:1302	Particularly, AMP reduced brain cell apoptosis and neurological deficits by activating the PI3K/AKT/mTOR signaling pathway and its downstream apoptotic protein family.
34663844	8	72	dep	inflammation	1125:1136	arg1	injury					1159:1164	injury	1159:1164	injury	1159:1164	AMP alleviated inflammation and oxidative stress injury in aging brain tissue by regulating the AMPK/SIRT1/NF-κB and Nrf2/HO-1 signaling pathways.
34663844	2	73	theme	fruit	378:382	arg1	component					342:350	the main component	333:350	the main component of the Aronia melanocarpa fruit	333:382	Aronia melanocarpa polysaccharide (AMP) is the main component of the Aronia melanocarpa fruit.
34663844	2	73	theme	fruit	378:382	arg1	polysaccharide					309:322	Aronia melanocarpa polysaccharide	290:322	Aronia melanocarpa polysaccharide (AMP)	290:328	Aronia melanocarpa polysaccharide (AMP) is the main component of the Aronia melanocarpa fruit.
34663844	0	74	theme	melanocarpa	7:17	arg1	polysaccharide					19:32	Aronia melanocarpa polysaccharide	0:32	Aronia melanocarpa polysaccharide	0:32	Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
34663844	11	75	theme	related	1821:1827	arg1	diseases					1839:1846	related metabolic diseases	1821:1846	related metabolic diseases	1821:1846	In summary, this study found that AMP delayed brain aging in mice by inhibiting inflammation and regulating intestinal microbes, which providing the possibility for the amelioration and treatment of aging and related metabolic diseases.
34663844	10	76	theme	AMP	1470:1472	arg1	treatment					1474:1482	the AMP treatment	1466:1482	the AMP treatment	1466:1482	Importantly, 16S rDNA analysis indicated the AMP treatment significantly retarded the aging process by improving the composition of intestinal flora and abundance of beneficial bacteria.
34663844	4	77	theme	200 mg/kg	700:708	arg1	1000 mg/kg					713:722	200 mg/kg to 1000 mg/kg	700:722	200 mg/kg to 1000 mg/kg	700:722	The aging model was established by intraperitoneal injection of D-Gal (200 mg/kg to 1000 mg/kg) once per 3 days for 12 weeks.
34663844	4	77	theme	200 mg/kg	700:708	arg1	D-Gal					693:697	D-Gal	693:697	D-Gal (200 mg/kg to 1000 mg/kg)	693:723	The aging model was established by intraperitoneal injection of D-Gal (200 mg/kg to 1000 mg/kg) once per 3 days for 12 weeks.
34663844	2	78	theme	Aronia	359:364	arg1	fruit					378:382	the Aronia melanocarpa fruit	355:382	the Aronia melanocarpa fruit	355:382	Aronia melanocarpa polysaccharide (AMP) is the main component of the Aronia melanocarpa fruit.
34663844	3	79	theme	aging	617:621	arg1	mice					623:626	aging mice	617:626	aging mice	617:626	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	3	80	theme	Aronia	455:460	arg1	fruit					474:478	Aronia melanocarpa fruit	455:478	Aronia melanocarpa fruit on aging mice	455:492	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	9	81	theme	PI3K/AKT/mTOR	1348:1360	arg1	pathway					1372:1378	the PI3K/AKT/mTOR signaling pathway	1344:1378	the PI3K/AKT/mTOR signaling pathway	1344:1378	Particularly, AMP reduced brain cell apoptosis and neurological deficits by activating the PI3K/AKT/mTOR signaling pathway and its downstream apoptotic protein family.
34663844	1	82	used	used	262:265	arg2	fruit					247:251	its fruit	243:251	its fruit	243:251	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	3	83	dep	delay	413:417	arg1	the					409:411	the	409:411	the	409:411	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	3	84	theme	flora	608:612	arg1	metabolism					579:588	the metabolism	575:588	the metabolism of the intestinal flora of aging mice	575:626	This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by D-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.
34663844	1	85	dep	activities	231:240	arg1	used					262:265	used	262:265	is often used for food and medicine	253:287	Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine.
34663844	9	86	theme	apoptotic	1399:1407	arg1	family					1417:1422	its downstream apoptotic protein family	1384:1422	its downstream apoptotic protein family	1384:1422	Particularly, AMP reduced brain cell apoptosis and neurological deficits by activating the PI3K/AKT/mTOR signaling pathway and its downstream apoptotic protein family.
34663844	8	87	from	inflammation	1125:1136	arg1	tissue					1181:1186	aging brain tissue	1169:1186	aging brain tissue	1169:1186	AMP alleviated inflammation and oxidative stress injury in aging brain tissue by regulating the AMPK/SIRT1/NF-κB and Nrf2/HO-1 signaling pathways.
34419814	0	0	theme	phosphate	103:111	arg1	capture					113:119	selective phosphate capture	93:119	selective phosphate capture	93:119	Biochar/Mg-Al spinel carboxymethyl cellulose-La hydrogels with cationic polymeric layers for selective phosphate capture.
34419814	0	1	theme	selective	93:101	arg1	capture					113:119	selective phosphate capture	93:119	selective phosphate capture	93:119	Biochar/Mg-Al spinel carboxymethyl cellulose-La hydrogels with cationic polymeric layers for selective phosphate capture.
34419814	4	2	theme	adsorbent	759:767	arg1	P/g					782:784	89.65 mg P/g	773:784	89.65 mg P/g	773:784	The maximum phosphate adsorption capacity of the adsorbent was 89.65 mg P/g at pH = 3.
34419814	4	2	theme	adsorbent	759:767	arg1	capacity					743:750	The maximum phosphate adsorption capacity	710:750	The maximum phosphate adsorption capacity of the adsorbent	710:767	The maximum phosphate adsorption capacity of the adsorbent was 89.65 mg P/g at pH = 3.
34419814	2	3	theme	component	569:577	arg1	multi-advantages					544:559	multi-advantages	544:559	multi-advantages of each component for enhanced phosphate capture	544:608	Herein, a new kind of adsorbent, in which biochar/Mg-Al spinel encapsulated in carboxymethyl cellulose-La hydrogels with cationic polymeric layers, was fabricated, aiming for integrating multi-advantages of each component for enhanced phosphate capture.
34419814	6	4	dep	anions	1091:1096	arg1	Cl-					1099:1101	Cl-	1099:1101	Cl-	1099:1101	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	1	5	theme	capturing	290:298	arg1	performance					300:310	capturing performance	290:310	capturing performance	290:310	Recently, biochar-related phosphate sorbents have been extensively investigated and achieved significant progress; however, there is still much room for enhancement on capturing performance and recovery of powdery ones after sorption.
34419814	8	6	theme	phosphate	1391:1399	arg1	mechanism					1378:1386	The adsorption mechanism	1363:1386	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components	1363:1457	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	8	6	theme	phosphate	1391:1399	arg1	exchange					1518:1525	ligand exchange	1511:1525	ligand exchange	1511:1525	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	8	6	theme	phosphate	1391:1399	arg1	complexation					1544:1555	inner-sphere complexation	1531:1555	inner-sphere complexation	1531:1555	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	8	6	theme	phosphate	1391:1399	arg1	attraction					1499:1508	the electrostatic attraction	1481:1508	the electrostatic attraction	1481:1508	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	5	7	theme	Langmuir	801:808	arg1	model					819:823	The Langmuir isotherm model	797:823	The Langmuir isotherm model	797:823	The Langmuir isotherm model and the pseudo-second-order kinetic model fitted well with the adsorption behavior of the adsorbent.
34419814	1	8	theme	biochar-related	132:146	arg1	sorbents					158:165	biochar-related phosphate sorbents	132:165	biochar-related phosphate sorbents	132:165	Recently, biochar-related phosphate sorbents have been extensively investigated and achieved significant progress; however, there is still much room for enhancement on capturing performance and recovery of powdery ones after sorption.
34419814	7	9	theme	column	1235:1240	arg1	experiments					1242:1252	fixed-bed column experiments	1225:1252	fixed-bed column experiments	1225:1252	By virtue of the bead-like feature, fixed-bed column experiments demonstrated that the Thomas model fitted the breakthrough curves well under varied experimental conditions.
34419814	8	10	from	mechanism	1378:1386	arg1	adsorbent					1427:1435	adsorbent	1427:1435	adsorbent	1427:1435	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	4	11	theme	phosphate	722:730	arg1	P/g					782:784	89.65 mg P/g	773:784	89.65 mg P/g	773:784	The maximum phosphate adsorption capacity of the adsorbent was 89.65 mg P/g at pH = 3.
34419814	4	11	theme	phosphate	722:730	arg1	capacity					743:750	The maximum phosphate adsorption capacity	710:750	The maximum phosphate adsorption capacity of the adsorbent	710:767	The maximum phosphate adsorption capacity of the adsorbent was 89.65 mg P/g at pH = 3.
34419814	5	12	theme	isotherm	810:817	arg1	model					819:823	The Langmuir isotherm model	797:823	The Langmuir isotherm model	797:823	The Langmuir isotherm model and the pseudo-second-order kinetic model fitted well with the adsorption behavior of the adsorbent.
34419814	7	13	theme	feature	1216:1222	arg1	virtue					1192:1197	virtue	1192:1197	virtue of the bead-like feature	1192:1222	By virtue of the bead-like feature, fixed-bed column experiments demonstrated that the Thomas model fitted the breakthrough curves well under varied experimental conditions.
34419814	7	14	theme	Thomas	1276:1281	arg1	model					1283:1287	the Thomas model	1272:1287	the Thomas model	1272:1287	By virtue of the bead-like feature, fixed-bed column experiments demonstrated that the Thomas model fitted the breakthrough curves well under varied experimental conditions.
34419814	0	15	theme	Biochar/Mg-Al	0:12	arg1	cellulose-La					35:46	Biochar/Mg-Al spinel carboxymethyl cellulose-La	0:46	Biochar/Mg-Al spinel carboxymethyl cellulose-La	0:46	Biochar/Mg-Al spinel carboxymethyl cellulose-La hydrogels with cationic polymeric layers for selective phosphate capture.
34419814	1	16	theme	significant	215:225	arg1	progress					227:234	significant progress	215:234	significant progress	215:234	Recently, biochar-related phosphate sorbents have been extensively investigated and achieved significant progress; however, there is still much room for enhancement on capturing performance and recovery of powdery ones after sorption.
34419814	0	17	theme	spinel	14:19	arg1	cellulose-La					35:46	Biochar/Mg-Al spinel carboxymethyl cellulose-La	0:46	Biochar/Mg-Al spinel carboxymethyl cellulose-La	0:46	Biochar/Mg-Al spinel carboxymethyl cellulose-La hydrogels with cationic polymeric layers for selective phosphate capture.
34419814	5	18	theme	pseudo-second-order	833:851	arg1	model					861:865	the pseudo-second-order kinetic model	829:865	the pseudo-second-order kinetic model	829:865	The Langmuir isotherm model and the pseudo-second-order kinetic model fitted well with the adsorption behavior of the adsorbent.
34419814	4	19	theme	maximum	714:720	arg1	P/g					782:784	89.65 mg P/g	773:784	89.65 mg P/g	773:784	The maximum phosphate adsorption capacity of the adsorbent was 89.65 mg P/g at pH = 3.
34419814	4	19	theme	maximum	714:720	arg1	capacity					743:750	The maximum phosphate adsorption capacity	710:750	The maximum phosphate adsorption capacity of the adsorbent	710:767	The maximum phosphate adsorption capacity of the adsorbent was 89.65 mg P/g at pH = 3.
34419814	3	20	theme	static	617:622	arg1	experiments					624:634	Batch static experiments	611:634	Batch static experiments	611:634	Batch static experiments were correlated to the phosphate adsorption performance of the adsorbent.
34419814	6	21	dep	Cl-	1099:1101	arg1	NO3-					1121:1124	NO3-	1121:1124	NO3-	1121:1124	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	6	21	dep	Cl-	1099:1101	arg1	HCO3-					1111:1115	HCO3-	1111:1115	HCO3-	1111:1115	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	6	21	dep	Cl-	1099:1101	arg1	SO42-					1104:1108	SO42-	1104:1108	SO42-	1104:1108	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	2	22	theme	cationic	478:485	arg1	layers					497:502	cationic polymeric layers	478:502	cationic polymeric layers	478:502	Herein, a new kind of adsorbent, in which biochar/Mg-Al spinel encapsulated in carboxymethyl cellulose-La hydrogels with cationic polymeric layers, was fabricated, aiming for integrating multi-advantages of each component for enhanced phosphate capture.
34419814	8	23	with	adsorbent	1427:1435	arg1	multi-components					1442:1457	multi-components	1442:1457	multi-components	1442:1457	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	4	24	theme	adsorption	732:741	arg1	P/g					782:784	89.65 mg P/g	773:784	89.65 mg P/g	773:784	The maximum phosphate adsorption capacity of the adsorbent was 89.65 mg P/g at pH = 3.
34419814	4	24	theme	adsorption	732:741	arg1	capacity					743:750	The maximum phosphate adsorption capacity	710:750	The maximum phosphate adsorption capacity of the adsorbent	710:767	The maximum phosphate adsorption capacity of the adsorbent was 89.65 mg P/g at pH = 3.
34419814	2	25	theme	enhanced	583:590	arg1	capture					602:608	enhanced phosphate capture	583:608	enhanced phosphate capture	583:608	Herein, a new kind of adsorbent, in which biochar/Mg-Al spinel encapsulated in carboxymethyl cellulose-La hydrogels with cationic polymeric layers, was fabricated, aiming for integrating multi-advantages of each component for enhanced phosphate capture.
34419814	6	26	theme	favorable	1053:1061	arg1	selectivity					1063:1073	favorable selectivity	1053:1073	favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-)	1053:1125	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	8	27	theme	electrostatic	1485:1497	arg1	attraction					1499:1508	the electrostatic attraction	1481:1508	the electrostatic attraction	1481:1508	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	8	27	theme	electrostatic	1485:1497	arg1	mechanism					1378:1386	The adsorption mechanism	1363:1386	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components	1363:1457	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	6	28	theme	good	1141:1144	arg1	reusability					1146:1156	good reusability	1141:1156	good reusability	1141:1156	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	2	29	theme	cellulose-La	450:461	arg1	hydrogels					463:471	carboxymethyl cellulose-La hydrogels	436:471	carboxymethyl cellulose-La hydrogels with cationic polymeric layers	436:502	Herein, a new kind of adsorbent, in which biochar/Mg-Al spinel encapsulated in carboxymethyl cellulose-La hydrogels with cationic polymeric layers, was fabricated, aiming for integrating multi-advantages of each component for enhanced phosphate capture.
34419814	0	30	theme	carboxymethyl	21:33	arg1	cellulose-La					35:46	Biochar/Mg-Al spinel carboxymethyl cellulose-La	0:46	Biochar/Mg-Al spinel carboxymethyl cellulose-La	0:46	Biochar/Mg-Al spinel carboxymethyl cellulose-La hydrogels with cationic polymeric layers for selective phosphate capture.
34419814	2	31	theme	phosphate	592:600	arg1	capture					602:608	enhanced phosphate capture	583:608	enhanced phosphate capture	583:608	Herein, a new kind of adsorbent, in which biochar/Mg-Al spinel encapsulated in carboxymethyl cellulose-La hydrogels with cationic polymeric layers, was fabricated, aiming for integrating multi-advantages of each component for enhanced phosphate capture.
34419814	3	32	theme	Batch	611:615	arg1	experiments					624:634	Batch static experiments	611:634	Batch static experiments	611:634	Batch static experiments were correlated to the phosphate adsorption performance of the adsorbent.
34419814	2	33	theme	carboxymethyl	436:448	arg1	hydrogels					463:471	carboxymethyl cellulose-La hydrogels	436:471	carboxymethyl cellulose-La hydrogels with cationic polymeric layers	436:502	Herein, a new kind of adsorbent, in which biochar/Mg-Al spinel encapsulated in carboxymethyl cellulose-La hydrogels with cationic polymeric layers, was fabricated, aiming for integrating multi-advantages of each component for enhanced phosphate capture.
34419814	5	34	theme	kinetic	853:859	arg1	model					861:865	the pseudo-second-order kinetic model	829:865	the pseudo-second-order kinetic model	829:865	The Langmuir isotherm model and the pseudo-second-order kinetic model fitted well with the adsorption behavior of the adsorbent.
34419814	1	35	theme	powdery	328:334	arg1	ones					336:339	powdery ones	328:339	powdery ones	328:339	Recently, biochar-related phosphate sorbents have been extensively investigated and achieved significant progress; however, there is still much room for enhancement on capturing performance and recovery of powdery ones after sorption.
34419814	1	36	from	enhancement	275:285	arg1	recovery					316:323	recovery	316:323	recovery of powdery ones after sorption	316:354	Recently, biochar-related phosphate sorbents have been extensively investigated and achieved significant progress; however, there is still much room for enhancement on capturing performance and recovery of powdery ones after sorption.
34419814	1	36	from	enhancement	275:285	arg1	performance					300:310	capturing performance	290:310	capturing performance	290:310	Recently, biochar-related phosphate sorbents have been extensively investigated and achieved significant progress; however, there is still much room for enhancement on capturing performance and recovery of powdery ones after sorption.
34419814	8	37	theme	adsorption	1367:1376	arg1	mechanism					1378:1386	The adsorption mechanism	1363:1386	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components	1363:1457	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	8	37	theme	adsorption	1367:1376	arg1	exchange					1518:1525	ligand exchange	1511:1525	ligand exchange	1511:1525	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	8	37	theme	adsorption	1367:1376	arg1	complexation					1544:1555	inner-sphere complexation	1531:1555	inner-sphere complexation	1531:1555	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	8	37	theme	adsorption	1367:1376	arg1	attraction					1499:1508	the electrostatic attraction	1481:1508	the electrostatic attraction	1481:1508	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	5	38	theme	adsorbent	915:923	arg1	behavior					899:906	the adsorption behavior	884:906	the adsorption behavior of the adsorbent	884:923	The Langmuir isotherm model and the pseudo-second-order kinetic model fitted well with the adsorption behavior of the adsorbent.
34419814	1	39	theme	ones	336:339	arg1	recovery					316:323	recovery	316:323	recovery of powdery ones after sorption	316:354	Recently, biochar-related phosphate sorbents have been extensively investigated and achieved significant progress; however, there is still much room for enhancement on capturing performance and recovery of powdery ones after sorption.
34419814	1	39	theme	ones	336:339	arg1	performance					300:310	capturing performance	290:310	capturing performance	290:310	Recently, biochar-related phosphate sorbents have been extensively investigated and achieved significant progress; however, there is still much room for enhancement on capturing performance and recovery of powdery ones after sorption.
34419814	6	40	dep	adsorbent	959:967	arg1	that					969:972	that	969:972	that	969:972	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	6	40	dep	adsorbent	959:967	arg1	integrated					974:983	integrated	974:983	integrated with biochar, Mg-Al spinel, cationic polymeric components	974:1041	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	5	41	theme	adsorption	888:897	arg1	behavior					899:906	the adsorption behavior	884:906	the adsorption behavior of the adsorbent	884:923	The Langmuir isotherm model and the pseudo-second-order kinetic model fitted well with the adsorption behavior of the adsorbent.
34419814	7	42	theme	fixed-bed	1225:1233	arg1	experiments					1242:1252	fixed-bed column experiments	1225:1252	fixed-bed column experiments	1225:1252	By virtue of the bead-like feature, fixed-bed column experiments demonstrated that the Thomas model fitted the breakthrough curves well under varied experimental conditions.
34419814	0	43	theme	polymeric	72:80	arg1	layers					82:87	cationic polymeric layers	63:87	cationic polymeric layers for selective phosphate capture	63:119	Biochar/Mg-Al spinel carboxymethyl cellulose-La hydrogels with cationic polymeric layers for selective phosphate capture.
34419814	6	44	theme	polymeric	1022:1030	arg1	biochar					990:996	biochar	990:996	biochar	990:996	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	6	44	theme	polymeric	1022:1030	arg1	components					1032:1041	cationic polymeric components	1013:1041	cationic polymeric components	1013:1041	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	3	45	theme	adsorbent	699:707	arg1	performance					680:690	the phosphate adsorption performance	655:690	the phosphate adsorption performance of the adsorbent	655:707	Batch static experiments were correlated to the phosphate adsorption performance of the adsorbent.
34419814	2	46	with	hydrogels	463:471	arg1	layers					497:502	cationic polymeric layers	478:502	cationic polymeric layers	478:502	Herein, a new kind of adsorbent, in which biochar/Mg-Al spinel encapsulated in carboxymethyl cellulose-La hydrogels with cationic polymeric layers, was fabricated, aiming for integrating multi-advantages of each component for enhanced phosphate capture.
34419814	2	47	theme	new	367:369	arg1	kind					371:374	a new kind	365:374	a new kind	365:374	Herein, a new kind of adsorbent, in which biochar/Mg-Al spinel encapsulated in carboxymethyl cellulose-La hydrogels with cationic polymeric layers, was fabricated, aiming for integrating multi-advantages of each component for enhanced phosphate capture.
34419814	0	48	theme	cationic	63:70	arg1	layers					82:87	cationic polymeric layers	63:87	cationic polymeric layers for selective phosphate capture	63:119	Biochar/Mg-Al spinel carboxymethyl cellulose-La hydrogels with cationic polymeric layers for selective phosphate capture.
34419814	8	49	theme	efficient	1586:1594	arg1	phosphate					1596:1604	the efficient phosphate	1582:1604	the efficient phosphate capturing performance	1582:1626	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	8	50	theme	ligand	1511:1516	arg1	mechanism					1378:1386	The adsorption mechanism	1363:1386	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components	1363:1457	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	8	50	theme	ligand	1511:1516	arg1	exchange					1518:1525	ligand exchange	1511:1525	ligand exchange	1511:1525	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	1	51	theme	phosphate	148:156	arg1	sorbents					158:165	biochar-related phosphate sorbents	132:165	biochar-related phosphate sorbents	132:165	Recently, biochar-related phosphate sorbents have been extensively investigated and achieved significant progress; however, there is still much room for enhancement on capturing performance and recovery of powdery ones after sorption.
34419814	4	52	from	pH = 3	789:794	arg1	P/g					782:784	89.65 mg P/g	773:784	89.65 mg P/g	773:784	The maximum phosphate adsorption capacity of the adsorbent was 89.65 mg P/g at pH = 3.
34419814	4	52	from	pH = 3	789:794	arg1	capacity					743:750	The maximum phosphate adsorption capacity	710:750	The maximum phosphate adsorption capacity of the adsorbent	710:767	The maximum phosphate adsorption capacity of the adsorbent was 89.65 mg P/g at pH = 3.
34419814	7	53	theme	experimental	1338:1349	arg1	conditions					1351:1360	varied experimental conditions	1331:1360	varied experimental conditions	1331:1360	By virtue of the bead-like feature, fixed-bed column experiments demonstrated that the Thomas model fitted the breakthrough curves well under varied experimental conditions.
34419814	8	54	theme	inner-sphere	1531:1542	arg1	mechanism					1378:1386	The adsorption mechanism	1363:1386	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components	1363:1457	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	8	54	theme	inner-sphere	1531:1542	arg1	complexation					1544:1555	inner-sphere complexation	1531:1555	inner-sphere complexation	1531:1555	The adsorption mechanism of phosphate on the designed composite adsorbent with multi-components could be described as the electrostatic attraction, ligand exchange and inner-sphere complexation, which might account for the efficient phosphate capturing performance.
34419814	7	55	theme	bead-like	1206:1214	arg1	feature					1216:1222	the bead-like feature	1202:1222	the bead-like feature	1202:1222	By virtue of the bead-like feature, fixed-bed column experiments demonstrated that the Thomas model fitted the breakthrough curves well under varied experimental conditions.
34419814	6	56	theme	coexisting	1080:1089	arg1	anions					1091:1096	coexisting anions	1080:1096	coexisting anions (Cl-, SO42-, HCO3- and NO3-)	1080:1125	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	6	57	theme	consecutive	1169:1179	arg1	cycles					1181:1186	five consecutive cycles	1164:1186	five consecutive cycles	1164:1186	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	7	58	theme	breakthrough	1300:1311	arg1	curves					1313:1318	the breakthrough curves	1296:1318	the breakthrough curves	1296:1318	By virtue of the bead-like feature, fixed-bed column experiments demonstrated that the Thomas model fitted the breakthrough curves well under varied experimental conditions.
34419814	3	59	theme	phosphate	659:667	arg1	performance					680:690	the phosphate adsorption performance	655:690	the phosphate adsorption performance of the adsorbent	655:707	Batch static experiments were correlated to the phosphate adsorption performance of the adsorbent.
34419814	7	60	theme	varied	1331:1336	arg1	conditions					1351:1360	varied experimental conditions	1331:1360	varied experimental conditions	1331:1360	By virtue of the bead-like feature, fixed-bed column experiments demonstrated that the Thomas model fitted the breakthrough curves well under varied experimental conditions.
34419814	2	61	theme	biochar/Mg-Al	399:411	arg1	spinel					413:418	biochar/Mg-Al spinel	399:418	biochar/Mg-Al spinel	399:418	Herein, a new kind of adsorbent, in which biochar/Mg-Al spinel encapsulated in carboxymethyl cellulose-La hydrogels with cationic polymeric layers, was fabricated, aiming for integrating multi-advantages of each component for enhanced phosphate capture.
34419814	2	62	theme	polymeric	487:495	arg1	layers					497:502	cationic polymeric layers	478:502	cationic polymeric layers	478:502	Herein, a new kind of adsorbent, in which biochar/Mg-Al spinel encapsulated in carboxymethyl cellulose-La hydrogels with cationic polymeric layers, was fabricated, aiming for integrating multi-advantages of each component for enhanced phosphate capture.
34419814	6	63	theme	Mg-Al	999:1003	arg1	biochar					990:996	biochar	990:996	biochar	990:996	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	6	63	theme	Mg-Al	999:1003	arg1	spinel					1005:1010	Mg-Al spinel	999:1010	Mg-Al spinel	999:1010	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	3	64	theme	adsorption	669:678	arg1	performance					680:690	the phosphate adsorption performance	655:690	the phosphate adsorption performance of the adsorbent	655:707	Batch static experiments were correlated to the phosphate adsorption performance of the adsorbent.
34419814	2	65	theme	adsorbent	379:387	arg1	kind					371:374	a new kind	365:374	a new kind	365:374	Herein, a new kind of adsorbent, in which biochar/Mg-Al spinel encapsulated in carboxymethyl cellulose-La hydrogels with cationic polymeric layers, was fabricated, aiming for integrating multi-advantages of each component for enhanced phosphate capture.
34419814	6	66	theme	cationic	1013:1020	arg1	biochar					990:996	biochar	990:996	biochar	990:996	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	6	66	theme	cationic	1013:1020	arg1	components					1032:1041	cationic polymeric components	1013:1041	cationic polymeric components	1013:1041	More importantly, this composite adsorbent that integrated with biochar, Mg-Al spinel, cationic polymeric components exhibited favorable selectivity over coexisting anions (Cl-, SO42-, HCO3- and NO3-) and performed good reusability after five consecutive cycles.
34419814	4	67	theme	89.65 mg	773:780	arg1	P/g					782:784	89.65 mg P/g	773:784	89.65 mg P/g	773:784	The maximum phosphate adsorption capacity of the adsorbent was 89.65 mg P/g at pH = 3.
34419814	4	67	theme	89.65 mg	773:780	arg1	capacity					743:750	The maximum phosphate adsorption capacity	710:750	The maximum phosphate adsorption capacity of the adsorbent	710:767	The maximum phosphate adsorption capacity of the adsorbent was 89.65 mg P/g at pH = 3.
34577078	3	0	theme	physical	976:983	arg1	exertion					985:992	intense physical exertion	968:992	intense physical exertion	968:992	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	9	1	theme	carbohydrates	2120:2132	arg1	fiber					2066:2070	fiber	2066:2070	fiber	2066:2070	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	1	theme	carbohydrates	2120:2132	arg1	electrolytes					2103:2114	electrolytes	2103:2114	electrolytes	2103:2114	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	1	theme	carbohydrates	2120:2132	arg1	protein					2042:2048	added protein	2036:2048	added protein	2036:2048	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	1	theme	carbohydrates	2120:2132	arg1	carbohydrates					2120:2132	carbohydrates	2120:2132	carbohydrates	2120:2132	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	1	theme	carbohydrates	2120:2132	arg1	prebiotics					2051:2060	prebiotics	2051:2060	prebiotics	2051:2060	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	1	theme	carbohydrates	2120:2132	arg1	amounts					2092:2098	defined amounts	2084:2098	defined amounts of electrolytes and carbohydrates	2084:2132	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	6	2	theme	antioxidant	1453:1463	arg1	properties					1465:1474	antioxidant properties	1453:1474	antioxidant properties	1453:1474	The drinks' polyphenols and antioxidant properties were measured spectrophotometrically, whilst vitamin C content was determined using high-pressure liquid chromatography.
34577078	6	3	theme	liquid	1574:1579	arg1	chromatography					1581:1594	high-pressure liquid chromatography	1560:1594	high-pressure liquid chromatography	1560:1594	The drinks' polyphenols and antioxidant properties were measured spectrophotometrically, whilst vitamin C content was determined using high-pressure liquid chromatography.
34577078	5	4	theme	fluidized-bed	1225:1237	arg1	milling					1243:1249	fluidized-bed jet milling	1225:1249	fluidized-bed jet milling	1225:1249	The study materials were raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber.
34577078	3	5	theme	high	997:1000	arg1	content					1002:1008	a high content	995:1008	a high content of nutrients	995:1021	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	4	6	theme	beverage	1123:1130	arg1	components					1132:1141	beverage components	1123:1141	beverage components	1123:1141	Furthermore, the relationships between regressive osmolalities of beverage components are herein investigated.
34577078	11	7	dep	components	2358:2367	arg1	carbohydrates					2390:2402	carbohydrates	2390:2402	carbohydrates	2390:2402	The design of appropriate recovery drink compositions was also greatly helped by investigating the relationships among the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein).
34577078	11	7	dep	components	2358:2367	arg1	powders					2411:2417	fruit powders	2405:2417	fruit powders	2405:2417	The design of appropriate recovery drink compositions was also greatly helped by investigating the relationships among the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein).
34577078	11	7	dep	components	2358:2367	arg1	electrolytes					2376:2387	electrolytes	2376:2387	electrolytes	2376:2387	The design of appropriate recovery drink compositions was also greatly helped by investigating the relationships among the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein).
34577078	11	7	dep	components	2358:2367	arg1	protein					2423:2429	protein	2423:2429	protein	2423:2429	The design of appropriate recovery drink compositions was also greatly helped by investigating the relationships among the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein).
34577078	0	8	theme	Prebiotic	119:127	arg1	Fiber					129:133	Prebiotic Fiber	119:133	Prebiotic Fiber	119:133	Designing Functional Fruit-Based Recovery Drinks in Powder Form That Contain Electrolytes, Peptides, Carbohydrates and Prebiotic Fiber Taking into Account Each Component's Osmolality.
34577078	6	9	theme	C	1529:1529	arg1	content					1531:1537	vitamin C content	1521:1537	vitamin C content	1521:1537	The drinks' polyphenols and antioxidant properties were measured spectrophotometrically, whilst vitamin C content was determined using high-pressure liquid chromatography.
34577078	1	10	theme	osmolalities	199:210	arg1	levels					189:194	High levels	184:194	High levels of osmolalities	184:210	High levels of osmolalities have been found in manufactured carbohydrate-based functional drinks that occasionally include added protein; however, fruit components rich in bioactive ingredients have been absent.
34577078	7	11	theme	scaling	1662:1668	arg1	method					1670:1675	a scaling method	1660:1675	a scaling method	1660:1675	The sensory qualities of each drink were assessed according to a scaling method.
34577078	2	12	theme	pH	699:700	arg1	levels					702:707	low pH levels	695:707	low pH levels	695:707	It has proved difficult to obtain recovery drinks based on natural fruit components that deliver calories and nutrients to the body whilst simultaneously ensuring that the body is adequately hydrated after physical exertion; the problem being that it is difficult to ensure the drinks' stability at low pH levels and maintain an appropriate sensory quality.
34577078	2	13	theme	physical	602:609	arg1	exertion					611:618	physical exertion	602:618	physical exertion	602:618	It has proved difficult to obtain recovery drinks based on natural fruit components that deliver calories and nutrients to the body whilst simultaneously ensuring that the body is adequately hydrated after physical exertion; the problem being that it is difficult to ensure the drinks' stability at low pH levels and maintain an appropriate sensory quality.
34577078	8	14	theme	total	1789:1793	arg1	content					1806:1812	total polyphenol content	1789:1812	total polyphenol content	1789:1812	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	2	15	theme	low	695:697	arg1	levels					702:707	low pH levels	695:707	low pH levels	695:707	It has proved difficult to obtain recovery drinks based on natural fruit components that deliver calories and nutrients to the body whilst simultaneously ensuring that the body is adequately hydrated after physical exertion; the problem being that it is difficult to ensure the drinks' stability at low pH levels and maintain an appropriate sensory quality.
34577078	3	16	theme	natural	797:803	arg1	components					811:820	natural fruit components	797:820	natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality	797:1054	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	9	17	theme	recovery	1977:1984	arg1	drinks					1986:1991	fruit-based recovery drinks	1965:1991	fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates	1965:2132	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	7	18	theme	drink	1627:1631	arg1	qualities					1609:1617	The sensory qualities	1597:1617	The sensory qualities of each drink	1597:1631	The sensory qualities of each drink were assessed according to a scaling method.
34577078	11	19	theme	appropriate	2213:2223	arg1	compositions					2240:2251	appropriate recovery drink compositions	2213:2251	appropriate recovery drink compositions	2213:2251	The design of appropriate recovery drink compositions was also greatly helped by investigating the relationships among the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein).
34577078	2	20	theme	appropriate	725:735	arg1	quality					745:751	an appropriate sensory quality	722:751	an appropriate sensory quality	722:751	It has proved difficult to obtain recovery drinks based on natural fruit components that deliver calories and nutrients to the body whilst simultaneously ensuring that the body is adequately hydrated after physical exertion; the problem being that it is difficult to ensure the drinks' stability at low pH levels and maintain an appropriate sensory quality.
34577078	1	21	theme	rich	348:351	arg1	components					337:346	fruit components	331:346	fruit components rich in bioactive ingredients	331:376	High levels of osmolalities have been found in manufactured carbohydrate-based functional drinks that occasionally include added protein; however, fruit components rich in bioactive ingredients have been absent.
34577078	5	22	dep	powders	1203:1209	arg1	prepared					1212:1219	prepared	1212:1219	prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying	1212:1289	The study materials were raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber.
34577078	9	23	theme	recommended	2000:2010	arg1	osmolality					2012:2021	the recommended osmolality	1996:2021	the recommended osmolality	1996:2021	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	1	24	theme	bioactive	356:364	arg1	ingredients					366:376	bioactive ingredients	356:376	bioactive ingredients	356:376	High levels of osmolalities have been found in manufactured carbohydrate-based functional drinks that occasionally include added protein; however, fruit components rich in bioactive ingredients have been absent.
34577078	3	25	theme	prebiotic	870:878	arg1	fiber					880:884	prebiotic fiber	870:884	prebiotic fiber	870:884	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	7	26	theme	sensory	1601:1607	arg1	qualities					1609:1617	The sensory qualities	1597:1617	The sensory qualities of each drink	1597:1631	The sensory qualities of each drink were assessed according to a scaling method.
34577078	3	27	theme	sensory	1040:1046	arg1	quality					1048:1054	a favorable sensory quality	1028:1054	a favorable sensory quality	1028:1054	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	28	theme	improved	902:909	arg1	water					911:915	an improved water	899:915	an improved water	899:915	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	11	29	theme	drink	2234:2238	arg1	compositions					2240:2251	appropriate recovery drink compositions	2213:2251	appropriate recovery drink compositions	2213:2251	The design of appropriate recovery drink compositions was also greatly helped by investigating the relationships among the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein).
34577078	9	30	theme	added	2036:2040	arg1	protein					2042:2048	added protein	2036:2048	added protein	2036:2048	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	5	31	theme	magnesium	1331:1339	arg1	salts					1341:1345	magnesium salts	1331:1345	magnesium salts	1331:1345	The study materials were raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber.
34577078	8	32	theme	C	1850:1850	arg1	level					1852:1856	vitamin C level	1842:1856	vitamin C level	1842:1856	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	3	33	theme	fruit	805:809	arg1	components					811:820	natural fruit components	797:820	natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality	797:1054	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	2	34	theme	fruit	463:467	arg1	components					469:478	natural fruit components	455:478	natural fruit components that deliver calories and nutrients to the body whilst simultaneously ensuring that the body is adequately hydrated after physical exertion	455:618	It has proved difficult to obtain recovery drinks based on natural fruit components that deliver calories and nutrients to the body whilst simultaneously ensuring that the body is adequately hydrated after physical exertion; the problem being that it is difficult to ensure the drinks' stability at low pH levels and maintain an appropriate sensory quality.
34577078	8	35	from	mL	1878:1879	arg1	which					1732:1736	which	1732:1736	which	1732:1736	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	0	36	theme	Fruit-Based	21:31	arg1	Drinks					42:47	Functional Fruit-Based Recovery Drinks	10:47	Functional Fruit-Based Recovery Drinks	10:47	Designing Functional Fruit-Based Recovery Drinks in Powder Form That Contain Electrolytes, Peptides, Carbohydrates and Prebiotic Fiber Taking into Account Each Component's Osmolality.
34577078	5	37	theme	raspberry	1193:1201	arg1	materials					1178:1186	The study materials	1168:1186	The study materials	1168:1186	The study materials were raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber.
34577078	5	37	theme	raspberry	1193:1201	arg1	powders					1203:1209	raspberry powders	1193:1209	raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber	1193:1422	The study materials were raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber.
34577078	1	38	from	ingredients	366:376	arg1	rich					348:351	rich	348:351	rich	348:351	High levels of osmolalities have been found in manufactured carbohydrate-based functional drinks that occasionally include added protein; however, fruit components rich in bioactive ingredients have been absent.
34577078	1	39	located	found	222:226	arg1	drinks					274:279	manufactured carbohydrate-based functional drinks	231:279	manufactured carbohydrate-based functional drinks that occasionally include added protein	231:319	High levels of osmolalities have been found in manufactured carbohydrate-based functional drinks that occasionally include added protein; however, fruit components rich in bioactive ingredients have been absent.
34577078	1	39	located	found	222:226	arg2	levels					189:194	High levels	184:194	High levels of osmolalities	184:210	High levels of osmolalities have been found in manufactured carbohydrate-based functional drinks that occasionally include added protein; however, fruit components rich in bioactive ingredients have been absent.
34577078	5	40	theme	whey	1383:1386	arg1	isolate					1396:1402	whey protein isolate	1383:1402	whey protein isolate	1383:1402	The study materials were raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber.
34577078	0	41	theme	Powder	52:57	arg1	Form					59:62	Powder Form	52:62	Powder Form	52:62	Designing Functional Fruit-Based Recovery Drinks in Powder Form That Contain Electrolytes, Peptides, Carbohydrates and Prebiotic Fiber Taking into Account Each Component's Osmolality.
34577078	1	42	theme	fruit	331:335	arg1	components					337:346	fruit components	331:346	fruit components rich in bioactive ingredients	331:376	High levels of osmolalities have been found in manufactured carbohydrate-based functional drinks that occasionally include added protein; however, fruit components rich in bioactive ingredients have been absent.
34577078	9	43	theme	defined	2084:2090	arg1	carbohydrates					2120:2132	carbohydrates	2120:2132	carbohydrates	2120:2132	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	43	theme	defined	2084:2090	arg1	electrolytes					2103:2114	electrolytes	2103:2114	electrolytes	2103:2114	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	43	theme	defined	2084:2090	arg1	amounts					2092:2098	defined amounts	2084:2098	defined amounts of electrolytes and carbohydrates	2084:2132	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	5	44	theme	jet	1239:1241	arg1	milling					1243:1249	fluidized-bed jet milling	1225:1249	fluidized-bed jet milling	1225:1249	The study materials were raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber.
34577078	11	45	theme	regressive	2322:2331	arg1	osmolalities					2333:2344	the regressive osmolalities	2318:2344	the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein)	2318:2430	The design of appropriate recovery drink compositions was also greatly helped by investigating the relationships among the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein).
34577078	1	46	theme	manufactured	231:242	arg1	drinks					274:279	manufactured carbohydrate-based functional drinks	231:279	manufactured carbohydrate-based functional drinks that occasionally include added protein	231:319	High levels of osmolalities have been found in manufactured carbohydrate-based functional drinks that occasionally include added protein; however, fruit components rich in bioactive ingredients have been absent.
34577078	3	47	theme	intense	968:974	arg1	exertion					985:992	intense physical exertion	968:992	intense physical exertion	968:992	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	8	48	theme	recovery	1699:1706	arg1	drinks					1708:1713	recovery drinks	1699:1713	recovery drinks	1699:1713	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	1	49	theme	functional	263:272	arg1	drinks					274:279	manufactured carbohydrate-based functional drinks	231:279	manufactured carbohydrate-based functional drinks that occasionally include added protein	231:319	High levels of osmolalities have been found in manufactured carbohydrate-based functional drinks that occasionally include added protein; however, fruit components rich in bioactive ingredients have been absent.
34577078	11	50	theme	components	2358:2367	arg1	osmolalities					2333:2344	the regressive osmolalities	2318:2344	the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein)	2318:2430	The design of appropriate recovery drink compositions was also greatly helped by investigating the relationships among the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein).
34577078	10	51	theme	sensory	2182:2188	arg1	quality					2190:2196	a satisfactorily sensory quality	2165:2196	a satisfactorily sensory quality	2165:2196	All drinks were found to have a satisfactorily sensory quality.
34577078	4	52	theme	components	1132:1141	arg1	osmolalities					1107:1118	regressive osmolalities	1096:1118	regressive osmolalities of beverage components	1096:1141	Furthermore, the relationships between regressive osmolalities of beverage components are herein investigated.
34577078	6	53	theme	high-pressure	1560:1572	arg1	chromatography					1581:1594	high-pressure liquid chromatography	1560:1594	high-pressure liquid chromatography	1560:1594	The drinks' polyphenols and antioxidant properties were measured spectrophotometrically, whilst vitamin C content was determined using high-pressure liquid chromatography.
34577078	5	54	theme	prebiotic	1408:1416	arg1	fiber					1418:1422	prebiotic fiber	1408:1422	prebiotic fiber	1408:1422	The study materials were raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber.
34577078	1	55	theme	High	184:187	arg1	levels					189:194	High levels	184:194	High levels of osmolalities	184:210	High levels of osmolalities have been found in manufactured carbohydrate-based functional drinks that occasionally include added protein; however, fruit components rich in bioactive ingredients have been absent.
34577078	3	56	theme	nutrients	1013:1021	arg1	content					1002:1008	a high content	995:1008	a high content of nutrients	995:1021	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	56	theme	nutrients	1013:1021	arg1	balance					933:939	electrolyte balance	921:939	electrolyte balance	921:939	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	56	theme	nutrients	1013:1021	arg1	quality					1048:1054	a favorable sensory quality	1028:1054	a favorable sensory quality	1028:1054	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	56	theme	nutrients	1013:1021	arg1	water					911:915	an improved water	899:915	an improved water	899:915	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	56	theme	nutrients	1013:1021	arg1	calories					946:953	the calories	942:953	the calories needed after intense physical exertion	942:992	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	56	theme	nutrients	1013:1021	arg1	fiber					880:884	prebiotic fiber	870:884	prebiotic fiber	870:884	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	56	theme	nutrients	1013:1021	arg1	protein					890:896	protein	890:896	protein	890:896	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	4	57	theme	regressive	1096:1105	arg1	osmolalities					1107:1118	regressive osmolalities	1096:1118	regressive osmolalities of beverage components	1096:1141	Furthermore, the relationships between regressive osmolalities of beverage components are herein investigated.
34577078	10	58	contain	have	2160:2163	arg1	drinks					2139:2144	All drinks	2135:2144	All drinks	2135:2144	All drinks were found to have a satisfactorily sensory quality.
34577078	10	58	contain	have	2160:2163	arg2	quality					2190:2196	a satisfactorily sensory quality	2165:2196	a satisfactorily sensory quality	2165:2196	All drinks were found to have a satisfactorily sensory quality.
34577078	8	59	theme	study	1920:1924	arg1	results					1926:1932	the study results	1916:1932	the study results	1916:1932	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	9	60	theme	osmolality	2012:2021	arg1	drinks					1986:1991	fruit-based recovery drinks	1965:1991	fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates	1965:2132	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	6	61	theme	vitamin	1521:1527	arg1	content					1531:1537	vitamin C content	1521:1537	vitamin C content	1521:1537	The drinks' polyphenols and antioxidant properties were measured spectrophotometrically, whilst vitamin C content was determined using high-pressure liquid chromatography.
34577078	8	62	dep	prepared	1720:1727	arg1	mL					1878:1879	8.1-20.6 mg/100 mL	1862:1879	8.1-20.6 mg/100 mL	1862:1879	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	8	62	dep	prepared	1720:1727	arg1	mL					1835:1836	27-49 mg GAE/100 mL	1818:1836	27-49 mg GAE/100 mL	1818:1836	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	8	63	theme	mOsm/kg	1774:1780	arg1	water					1782:1786	388 to 607 mOsm/kg water	1763:1786	388 to 607 mOsm/kg water	1763:1786	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	9	64	theme	fruit-based	1965:1975	arg1	drinks					1986:1991	fruit-based recovery drinks	1965:1991	fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates	1965:2132	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	8	65	from	mL	1835:1836	arg1	which					1732:1736	which	1732:1736	which	1732:1736	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	11	66	dep	electrolytes	2376:2387	arg1	i.e.					2370:2373	i.e.	2370:2373	i.e.	2370:2373	The design of appropriate recovery drink compositions was also greatly helped by investigating the relationships among the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein).
34577078	2	67	theme	sensory	737:743	arg1	quality					745:751	an appropriate sensory quality	722:751	an appropriate sensory quality	722:751	It has proved difficult to obtain recovery drinks based on natural fruit components that deliver calories and nutrients to the body whilst simultaneously ensuring that the body is adequately hydrated after physical exertion; the problem being that it is difficult to ensure the drinks' stability at low pH levels and maintain an appropriate sensory quality.
34577078	9	68	contain	contain	2028:2034	arg2	electrolytes					2103:2114	electrolytes	2103:2114	electrolytes	2103:2114	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	68	contain	contain	2028:2034	arg2	prebiotics					2051:2060	prebiotics	2051:2060	prebiotics	2051:2060	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	68	contain	contain	2028:2034	arg1	drinks					1986:1991	fruit-based recovery drinks	1965:1991	fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates	1965:2132	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	68	contain	contain	2028:2034	arg2	carbohydrates					2120:2132	carbohydrates	2120:2132	carbohydrates	2120:2132	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	68	contain	contain	2028:2034	arg2	amounts					2092:2098	defined amounts	2084:2098	defined amounts of electrolytes and carbohydrates	2084:2132	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	68	contain	contain	2028:2034	arg2	fiber					2066:2070	fiber	2066:2070	fiber	2066:2070	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	68	contain	contain	2028:2034	arg2	protein					2042:2048	added protein	2036:2048	added protein	2036:2048	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	8	69	theme	polyphenol	1795:1804	arg1	content					1806:1812	total polyphenol content	1789:1812	total polyphenol content	1789:1812	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	11	70	theme	recovery	2225:2232	arg1	compositions					2240:2251	appropriate recovery drink compositions	2213:2251	appropriate recovery drink compositions	2213:2251	The design of appropriate recovery drink compositions was also greatly helped by investigating the relationships among the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein).
34577078	8	71	dep	607	1770:1772	arg1	to					1767:1768	to	1767:1768	to	1767:1768	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	3	72	theme	added	835:839	arg1	electrolytes					841:852	added electrolytes	835:852	added electrolytes	835:852	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	73	theme	favorable	1030:1038	arg1	quality					1048:1054	a favorable sensory quality	1028:1054	a favorable sensory quality	1028:1054	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	8	74	theme	mg	1824:1825	arg1	mL					1835:1836	27-49 mg GAE/100 mL	1818:1836	27-49 mg GAE/100 mL	1818:1836	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	11	75	theme	compositions	2240:2251	arg1	design					2203:2208	The design	2199:2208	The design of appropriate recovery drink compositions	2199:2251	The design of appropriate recovery drink compositions was also greatly helped by investigating the relationships among the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein).
34577078	0	76	theme	Functional	10:19	arg1	Drinks					42:47	Functional Fruit-Based Recovery Drinks	10:47	Functional Fruit-Based Recovery Drinks	10:47	Designing Functional Fruit-Based Recovery Drinks in Powder Form That Contain Electrolytes, Peptides, Carbohydrates and Prebiotic Fiber Taking into Account Each Component's Osmolality.
34577078	8	77	theme	vitamin	1842:1848	arg1	C					1850:1850	vitamin C	1842:1850	vitamin C level	1842:1856	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	2	78	theme	natural	455:461	arg1	components					469:478	natural fruit components	455:478	natural fruit components that deliver calories and nutrients to the body whilst simultaneously ensuring that the body is adequately hydrated after physical exertion	455:618	It has proved difficult to obtain recovery drinks based on natural fruit components that deliver calories and nutrients to the body whilst simultaneously ensuring that the body is adequately hydrated after physical exertion; the problem being that it is difficult to ensure the drinks' stability at low pH levels and maintain an appropriate sensory quality.
34577078	11	79	theme	fruit	2405:2409	arg1	powders					2411:2417	fruit powders	2405:2417	fruit powders	2405:2417	The design of appropriate recovery drink compositions was also greatly helped by investigating the relationships among the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein).
34577078	5	80	theme	citrated	1303:1310	arg1	sodium					1312:1317	citrated sodium	1303:1317	citrated sodium	1303:1317	The study materials were raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber.
34577078	0	81	theme	Recovery	33:40	arg1	Drinks					42:47	Functional Fruit-Based Recovery Drinks	10:47	Functional Fruit-Based Recovery Drinks	10:47	Designing Functional Fruit-Based Recovery Drinks in Powder Form That Contain Electrolytes, Peptides, Carbohydrates and Prebiotic Fiber Taking into Account Each Component's Osmolality.
34577078	1	82	theme	added	307:311	arg1	protein					313:319	added protein	307:319	added protein	307:319	High levels of osmolalities have been found in manufactured carbohydrate-based functional drinks that occasionally include added protein; however, fruit components rich in bioactive ingredients have been absent.
34577078	2	83	theme	recovery	430:437	arg1	drinks					439:444	recovery drinks	430:444	recovery drinks based on natural fruit components that deliver calories and nutrients to the body whilst simultaneously ensuring that the body is adequately hydrated after physical exertion	430:618	It has proved difficult to obtain recovery drinks based on natural fruit components that deliver calories and nutrients to the body whilst simultaneously ensuring that the body is adequately hydrated after physical exertion; the problem being that it is difficult to ensure the drinks' stability at low pH levels and maintain an appropriate sensory quality.
34577078	3	84	theme	electrolyte	921:931	arg1	balance					933:939	electrolyte balance	921:939	electrolyte balance	921:939	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	1	85	from	rich	348:351	arg1	ingredients					366:376	bioactive ingredients	356:376	bioactive ingredients	356:376	High levels of osmolalities have been found in manufactured carbohydrate-based functional drinks that occasionally include added protein; however, fruit components rich in bioactive ingredients have been absent.
34577078	3	86	contain	contain	827:833	arg2	fiber					880:884	prebiotic fiber	870:884	prebiotic fiber	870:884	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	86	contain	contain	827:833	arg2	water					911:915	an improved water	899:915	an improved water	899:915	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	86	contain	contain	827:833	arg2	calories					946:953	the calories	942:953	the calories needed after intense physical exertion	942:992	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	86	contain	contain	827:833	arg2	protein					890:896	protein	890:896	protein	890:896	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	86	contain	contain	827:833	arg1	components					811:820	natural fruit components	797:820	natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality	797:1054	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	86	contain	contain	827:833	arg2	content					1002:1008	a high content	995:1008	a high content of nutrients	995:1021	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	86	contain	contain	827:833	arg2	electrolytes					841:852	added electrolytes	835:852	added electrolytes	835:852	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	3	86	contain	contain	827:833	arg2	quality					1048:1054	a favorable sensory quality	1028:1054	a favorable sensory quality	1028:1054	This study aims to develop drinks based on natural fruit components that contain added electrolytes, carbohydrates, prebiotic fiber and protein; an improved water and electrolyte balance; the calories needed after intense physical exertion; a high content of nutrients; and a favorable sensory quality.
34577078	5	87	theme	protein	1388:1394	arg1	isolate					1396:1402	whey protein isolate	1383:1402	whey protein isolate	1383:1402	The study materials were raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber.
34577078	8	88	theme	test	1682:1685	arg1	versions					1687:1694	Six test versions	1678:1694	Six test versions of recovery drinks	1678:1713	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	5	89	theme	study	1172:1176	arg1	materials					1178:1186	The study materials	1168:1186	The study materials	1168:1186	The study materials were raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber.
34577078	5	89	theme	study	1172:1176	arg1	powders					1203:1209	raspberry powders	1193:1209	raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber	1193:1422	The study materials were raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber.
34577078	11	90	theme	beverage	2349:2356	arg1	components					2358:2367	beverage components	2349:2367	beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein)	2349:2430	The design of appropriate recovery drink compositions was also greatly helped by investigating the relationships among the regressive osmolalities of beverage components (i.e., electrolytes, carbohydrates, fruit powders and protein).
34577078	9	91	theme	electrolytes	2103:2114	arg1	fiber					2066:2070	fiber	2066:2070	fiber	2066:2070	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	91	theme	electrolytes	2103:2114	arg1	electrolytes					2103:2114	electrolytes	2103:2114	electrolytes	2103:2114	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	91	theme	electrolytes	2103:2114	arg1	protein					2042:2048	added protein	2036:2048	added protein	2036:2048	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	91	theme	electrolytes	2103:2114	arg1	carbohydrates					2120:2132	carbohydrates	2120:2132	carbohydrates	2120:2132	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	91	theme	electrolytes	2103:2114	arg1	prebiotics					2051:2060	prebiotics	2051:2060	prebiotics	2051:2060	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	9	91	theme	electrolytes	2103:2114	arg1	amounts					2092:2098	defined amounts	2084:2098	defined amounts of electrolytes and carbohydrates	2084:2132	It is thus possible to obtain fruit-based recovery drinks of the recommended osmolality that contain added protein, prebiotics and fiber, as well as defined amounts of electrolytes and carbohydrates.
34577078	5	92	theme	hydrolyzed	1362:1371	arg1	collagen					1373:1380	hydrolyzed collagen	1362:1380	hydrolyzed collagen	1362:1380	The study materials were raspberry powders (prepared via fluidized-bed jet milling, drying, freeze-drying and spray-drying) as well as citrated sodium, potassium, magnesium salts, isomaltulose, hydrolyzed collagen, whey protein isolate and prebiotic fiber.
34577078	8	93	theme	drinks	1708:1713	arg1	versions					1687:1694	Six test versions	1678:1694	Six test versions of recovery drinks	1678:1713	Six test versions of recovery drinks were prepared in which osmolalities ranged from 388 to 607 mOsm/kg water, total polyphenol content was 27-49 mg GAE/100 mL and vitamin C level was 8.1-20.6 mg/100 mL, following compositions defined by the study results.
34577078	1	94	theme	carbohydrate-based	244:261	arg1	drinks					274:279	manufactured carbohydrate-based functional drinks	231:279	manufactured carbohydrate-based functional drinks that occasionally include added protein	231:319	High levels of osmolalities have been found in manufactured carbohydrate-based functional drinks that occasionally include added protein; however, fruit components rich in bioactive ingredients have been absent.
33570055	1	0	theme	Liposomal	56:64	arg1	formulations					66:77	Liposomal formulations	56:77	Liposomal formulations	56:77	Liposomal formulations are used to improve the safety and cellular absorption of conventional drugs by limiting their interaction with phagocytes.
33570055	4	1	theme	cancer	730:735	arg1	cells					737:741	cancer cells	730:741	cancer cells	730:741	Yet, we observed that a peak of the uptake extent of cationic liposomes was reached at a clinically relevant concentration of heparin for phagocytes and cancer cells.
33570055	2	2	theme	anticoagulant	319:331	arg1	presence					304:311	the presence	300:311	the presence of an anticoagulant in the blood	300:344	The uptake behaviour of these nanocarriers is affected by the blood composition, and accordingly the presence of an anticoagulant in the blood could have a critical impact on the efficiency of nanomedicines.
33570055	5	3	theme	cationic	813:820	arg1	nanomedicines					822:834	cationic nanomedicines	813:834	cationic nanomedicines	813:834	Hence, we recommend avoiding treatment of a heparinized patient with cationic nanomedicines because unexpectedly high uptake can occur in phagocytes.
33570055	2	4	contain	have	352:355	arg1	presence					304:311	the presence	300:311	the presence of an anticoagulant in the blood	300:344	The uptake behaviour of these nanocarriers is affected by the blood composition, and accordingly the presence of an anticoagulant in the blood could have a critical impact on the efficiency of nanomedicines.
33570055	2	4	contain	have	352:355	arg2	impact					368:373	a critical impact	357:373	a critical impact	357:373	The uptake behaviour of these nanocarriers is affected by the blood composition, and accordingly the presence of an anticoagulant in the blood could have a critical impact on the efficiency of nanomedicines.
33570055	5	5	theme	high	857:860	arg1	uptake					862:867	unexpectedly high uptake	844:867	unexpectedly high uptake	844:867	Hence, we recommend avoiding treatment of a heparinized patient with cationic nanomedicines because unexpectedly high uptake can occur in phagocytes.
33570055	3	6	theme	charged	430:436	arg1	liposomes					438:446	the negatively charged liposomes	415:446	the negatively charged liposomes	415:446	For the negatively charged liposomes, such as AmBisome®, no significant change in the uptake could be observed when co-incubated with heparin and primary phagocytes.
33570055	3	6	theme	charged	430:436	arg1	AmBisome®					457:465	AmBisome®	457:465	AmBisome®	457:465	For the negatively charged liposomes, such as AmBisome®, no significant change in the uptake could be observed when co-incubated with heparin and primary phagocytes.
33570055	5	7	theme	avoiding	764:771	arg1	treatment					773:781	avoiding treatment	764:781	avoiding treatment of a heparinized patient with cationic nanomedicines	764:834	Hence, we recommend avoiding treatment of a heparinized patient with cationic nanomedicines because unexpectedly high uptake can occur in phagocytes.
33570055	4	8	theme	extent	620:625	arg1	peak					601:604	a peak	599:604	a peak of the uptake extent of cationic liposomes	599:647	Yet, we observed that a peak of the uptake extent of cationic liposomes was reached at a clinically relevant concentration of heparin for phagocytes and cancer cells.
33570055	4	9	theme	liposomes	639:647	arg1	extent					620:625	the uptake extent	609:625	the uptake extent of cationic liposomes	609:647	Yet, we observed that a peak of the uptake extent of cationic liposomes was reached at a clinically relevant concentration of heparin for phagocytes and cancer cells.
33570055	3	10	theme	primary	557:563	arg1	phagocytes					565:574	primary phagocytes	557:574	primary phagocytes	557:574	For the negatively charged liposomes, such as AmBisome®, no significant change in the uptake could be observed when co-incubated with heparin and primary phagocytes.
33570055	4	11	theme	cationic	630:637	arg1	liposomes					639:647	cationic liposomes	630:647	cationic liposomes	630:647	Yet, we observed that a peak of the uptake extent of cationic liposomes was reached at a clinically relevant concentration of heparin for phagocytes and cancer cells.
33570055	0	12	theme	cellular	22:29	arg1	uptake					31:36	the cellular uptake	18:36	the cellular uptake of nanomedicines	18:53	Heparin modulates the cellular uptake of nanomedicines.
33570055	3	13	from	change	483:488	arg1	uptake					497:502	the uptake	493:502	the uptake	493:502	For the negatively charged liposomes, such as AmBisome®, no significant change in the uptake could be observed when co-incubated with heparin and primary phagocytes.
33570055	5	14	theme	patient	800:806	arg1	treatment					773:781	avoiding treatment	764:781	avoiding treatment of a heparinized patient with cationic nanomedicines	764:834	Hence, we recommend avoiding treatment of a heparinized patient with cationic nanomedicines because unexpectedly high uptake can occur in phagocytes.
33570055	4	15	theme	heparin	703:709	arg1	concentration					686:698	a clinically relevant concentration	664:698	a clinically relevant concentration of heparin for phagocytes and cancer cells	664:741	Yet, we observed that a peak of the uptake extent of cationic liposomes was reached at a clinically relevant concentration of heparin for phagocytes and cancer cells.
33570055	2	16	theme	critical	359:366	arg1	impact					368:373	a critical impact	357:373	a critical impact	357:373	The uptake behaviour of these nanocarriers is affected by the blood composition, and accordingly the presence of an anticoagulant in the blood could have a critical impact on the efficiency of nanomedicines.
33570055	2	17	attach	presence	304:311	arg2	anticoagulant					319:331	an anticoagulant	316:331	an anticoagulant	316:331	The uptake behaviour of these nanocarriers is affected by the blood composition, and accordingly the presence of an anticoagulant in the blood could have a critical impact on the efficiency of nanomedicines.
33570055	2	17	attach	presence	304:311	arg1	blood					340:344	the blood	336:344	the blood	336:344	The uptake behaviour of these nanocarriers is affected by the blood composition, and accordingly the presence of an anticoagulant in the blood could have a critical impact on the efficiency of nanomedicines.
33570055	5	18	with	patient	800:806	arg1	nanomedicines					822:834	cationic nanomedicines	813:834	cationic nanomedicines	813:834	Hence, we recommend avoiding treatment of a heparinized patient with cationic nanomedicines because unexpectedly high uptake can occur in phagocytes.
33570055	4	19	theme	uptake	613:618	arg1	extent					620:625	the uptake extent	609:625	the uptake extent of cationic liposomes	609:647	Yet, we observed that a peak of the uptake extent of cationic liposomes was reached at a clinically relevant concentration of heparin for phagocytes and cancer cells.
33570055	2	20	theme	nanomedicines	396:408	arg1	efficiency					382:391	the efficiency	378:391	the efficiency of nanomedicines	378:408	The uptake behaviour of these nanocarriers is affected by the blood composition, and accordingly the presence of an anticoagulant in the blood could have a critical impact on the efficiency of nanomedicines.
33570055	2	21	theme	nanocarriers	233:244	arg1	behaviour					214:222	The uptake behaviour	203:222	The uptake behaviour of these nanocarriers	203:244	The uptake behaviour of these nanocarriers is affected by the blood composition, and accordingly the presence of an anticoagulant in the blood could have a critical impact on the efficiency of nanomedicines.
33570055	3	22	theme	significant	471:481	arg1	change					483:488	no significant change	468:488	no significant change in the uptake	468:502	For the negatively charged liposomes, such as AmBisome®, no significant change in the uptake could be observed when co-incubated with heparin and primary phagocytes.
33570055	0	23	theme	nanomedicines	41:53	arg1	uptake					31:36	the cellular uptake	18:36	the cellular uptake of nanomedicines	18:53	Heparin modulates the cellular uptake of nanomedicines.
33570055	2	24	theme	uptake	207:212	arg1	behaviour					214:222	The uptake behaviour	203:222	The uptake behaviour of these nanocarriers	203:244	The uptake behaviour of these nanocarriers is affected by the blood composition, and accordingly the presence of an anticoagulant in the blood could have a critical impact on the efficiency of nanomedicines.
33570055	1	25	theme	cellular	114:121	arg1	absorption					123:132	cellular absorption	114:132	cellular absorption	114:132	Liposomal formulations are used to improve the safety and cellular absorption of conventional drugs by limiting their interaction with phagocytes.
33570055	4	26	theme	relevant	677:684	arg1	concentration					686:698	a clinically relevant concentration	664:698	a clinically relevant concentration of heparin for phagocytes and cancer cells	664:741	Yet, we observed that a peak of the uptake extent of cationic liposomes was reached at a clinically relevant concentration of heparin for phagocytes and cancer cells.
33570055	1	27	theme	conventional	137:148	arg1	drugs					150:154	conventional drugs	137:154	conventional drugs	137:154	Liposomal formulations are used to improve the safety and cellular absorption of conventional drugs by limiting their interaction with phagocytes.
33570055	2	28	theme	blood	265:269	arg1	composition					271:281	the blood composition	261:281	the blood composition	261:281	The uptake behaviour of these nanocarriers is affected by the blood composition, and accordingly the presence of an anticoagulant in the blood could have a critical impact on the efficiency of nanomedicines.
33570055	1	29	with	interaction	174:184	arg1	phagocytes					191:200	phagocytes	191:200	phagocytes	191:200	Liposomal formulations are used to improve the safety and cellular absorption of conventional drugs by limiting their interaction with phagocytes.
33570055	1	30	theme	drugs	150:154	arg1	absorption					123:132	cellular absorption	114:132	cellular absorption	114:132	Liposomal formulations are used to improve the safety and cellular absorption of conventional drugs by limiting their interaction with phagocytes.
33570055	1	30	theme	drugs	150:154	arg1	safety					103:108	safety	103:108	safety	103:108	Liposomal formulations are used to improve the safety and cellular absorption of conventional drugs by limiting their interaction with phagocytes.
33570055	1	31	used	used	83:86	arg2	formulations					66:77	Liposomal formulations	56:77	Liposomal formulations	56:77	Liposomal formulations are used to improve the safety and cellular absorption of conventional drugs by limiting their interaction with phagocytes.
33570055	5	32	theme	heparinized	788:798	arg1	patient					800:806	a heparinized patient	786:806	a heparinized patient with cationic nanomedicines	786:834	Hence, we recommend avoiding treatment of a heparinized patient with cationic nanomedicines because unexpectedly high uptake can occur in phagocytes.
33570055	1	33	dep	safety	103:108	arg1	the					99:101	the	99:101	the	99:101	Liposomal formulations are used to improve the safety and cellular absorption of conventional drugs by limiting their interaction with phagocytes.
33570055	2	34	from	presence	304:311	arg1	blood					340:344	the blood	336:344	the blood	336:344	The uptake behaviour of these nanocarriers is affected by the blood composition, and accordingly the presence of an anticoagulant in the blood could have a critical impact on the efficiency of nanomedicines.
32299554	4	0	theme	nanocomposite	535:547	arg1	ink					558:560	a green nanocomposite printing ink	527:560	a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls)	527:701	In this work, we showed a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls).
32299554	0	1	theme	nanoclay	96:103	arg1	incorporation					105:117	nanoclay incorporation	96:117	nanoclay incorporation	96:117	A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel with enhanced stability via nanoclay incorporation.
32299554	1	2	dep	Three-dimensional	120:136	arg1	3D					139:140	3D	139:140	3D	139:140	Three-dimensional (3D) printing offers a novel approach to manufacture repeatable personalized structures for mass customization in medical fields.
32299554	2	3	theme	printing	411:418	arg1	material					420:427	a promising printing material	399:427	a promising printing material	399:427	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	2	3	theme	printing	411:418	arg1	hydrogel					387:394	polysaccharide-based hydrogel	366:394	polysaccharide-based hydrogel	366:394	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	5	4	theme	engineering	957:967	arg1	application					898:908	medical application	890:908	medical application of drug release, biomedical devices and tissue engineering	890:967	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	5	5	theme	devices	938:944	arg1	application					898:908	medical application	890:908	medical application of drug release, biomedical devices and tissue engineering	890:967	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	5	6	theme	release	833:839	arg1	behavior					841:848	a long-term release behavior	821:848	a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering	821:967	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	5	6	theme	release	833:839	arg1	attractive					876:885	attractive	876:885	attractive	876:885	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	1	7	theme	repeatable	191:200	arg1	structures					215:224	repeatable personalized structures	191:224	repeatable personalized structures for mass customization in medical fields	191:265	Three-dimensional (3D) printing offers a novel approach to manufacture repeatable personalized structures for mass customization in medical fields.
32299554	5	8	theme	long-term	823:831	arg1	behavior					841:848	a long-term release behavior	821:848	a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering	821:967	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	5	8	theme	long-term	823:831	arg1	attractive					876:885	attractive	876:885	attractive	876:885	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	4	9	theme	green	529:533	arg1	ink					558:560	a green nanocomposite printing ink	527:560	a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls)	527:701	In this work, we showed a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls).
32299554	1	10	theme	personalized	202:213	arg1	structures					215:224	repeatable personalized structures	191:224	repeatable personalized structures for mass customization in medical fields	191:265	Three-dimensional (3D) printing offers a novel approach to manufacture repeatable personalized structures for mass customization in medical fields.
32299554	0	11	theme	3D-printable	2:13	arg1	hydrogel					59:66	A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel	0:66	A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel with	0:71	A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel with enhanced stability via nanoclay incorporation.
32299554	2	12	theme	polysaccharide-based	366:385	arg1	material					420:427	a promising printing material	399:427	a promising printing material	399:427	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	2	12	theme	polysaccharide-based	366:385	arg1	hydrogel					387:394	polysaccharide-based hydrogel	366:394	polysaccharide-based hydrogel	366:394	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	4	13	theme	-oxidized	616:624	arg1	TOBC					647:650	TOBC	647:650	TOBC	647:650	In this work, we showed a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls).
32299554	4	13	theme	-oxidized	616:624	arg1	cellulose					636:644	bacterial cellulose	626:644	bacterial cellulose (TOBC)	626:651	In this work, we showed a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls).
32299554	1	14	theme	Three-dimensional	120:136	arg1	printing					143:150	Three-dimensional (3D) printing	120:150	Three-dimensional (3D) printing	120:150	Three-dimensional (3D) printing offers a novel approach to manufacture repeatable personalized structures for mass customization in medical fields.
32299554	5	15	theme	biomedical	927:936	arg1	devices					938:944	biomedical devices	927:944	biomedical devices	927:944	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	0	16	theme	bacterial	30:38	arg1	hydrogel					59:66	A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel	0:66	A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel with	0:71	A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel with enhanced stability via nanoclay incorporation.
32299554	2	17	from	resemblance	284:294	arg1	microstructure					328:341	microstructure	328:341	microstructure	328:341	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	2	17	from	resemblance	284:294	arg1	composition					312:322	composition	312:322	composition	312:322	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	1	18	theme	mass	230:233	arg1	customization					235:247	mass customization	230:247	mass customization in medical fields	230:265	Three-dimensional (3D) printing offers a novel approach to manufacture repeatable personalized structures for mass customization in medical fields.
32299554	0	19	theme	TEMPO-oxidized	15:28	arg1	hydrogel					59:66	A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel	0:66	A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel with	0:71	A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel with enhanced stability via nanoclay incorporation.
32299554	2	20	theme	biological	346:355	arg1	tissues					357:363	biological tissues	346:363	biological tissues	346:363	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	5	21	theme	drug	913:916	arg1	release					918:924	drug release	913:924	drug release	913:924	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	4	22	theme	bacterial	626:634	arg1	TOBC					647:650	TOBC	647:650	TOBC	647:650	In this work, we showed a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls).
32299554	4	22	theme	bacterial	626:634	arg1	cellulose					636:644	bacterial cellulose	626:644	bacterial cellulose (TOBC)	626:651	In this work, we showed a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls).
32299554	5	23	theme	3D	745:746	arg1	ink					757:759	the 3D printing ink	741:759	the 3D printing ink	741:759	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	2	24	from	materials	299:307	arg1	microstructure					328:341	microstructure	328:341	microstructure	328:341	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	2	24	from	materials	299:307	arg1	composition					312:322	composition	312:322	composition	312:322	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	0	25	theme	cellulose/alginate	40:57	arg1	hydrogel					59:66	A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel	0:66	A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel with	0:71	A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel with enhanced stability via nanoclay incorporation.
32299554	5	26	theme	medical	890:896	arg1	application					898:908	medical application	890:908	medical application of drug release, biomedical devices and tissue engineering	890:967	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	5	27	theme	printing	748:755	arg1	ink					757:759	the 3D printing ink	741:759	the 3D printing ink	741:759	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	1	28	theme	medical	252:258	arg1	fields					260:265	medical fields	252:265	medical fields	252:265	Three-dimensional (3D) printing offers a novel approach to manufacture repeatable personalized structures for mass customization in medical fields.
32299554	5	29	from	attractive	876:885	arg1	application					898:908	medical application	890:908	medical application of drug release, biomedical devices and tissue engineering	890:967	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	2	30	theme	promising	401:409	arg1	material					420:427	a promising printing material	399:427	a promising printing material	399:427	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	2	30	theme	promising	401:409	arg1	hydrogel					387:394	polysaccharide-based hydrogel	366:394	polysaccharide-based hydrogel	366:394	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	3	31	theme	structure	466:474	arg1	problem					494:500	a problem	492:500	a problem	492:500	However, its long-term stability of structure has always been a problem.
32299554	3	31	theme	structure	466:474	arg1	stability					453:461	its long-term stability	439:461	its long-term stability of structure	439:474	However, its long-term stability of structure has always been a problem.
32299554	5	32	theme	TOBC/SA/Xls	708:718	arg1	hydrogel					720:727	The TOBC/SA/Xls hydrogel	704:727	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink	704:759	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	1	33	from	customization	235:247	arg1	fields					260:265	medical fields	252:265	medical fields	252:265	Three-dimensional (3D) printing offers a novel approach to manufacture repeatable personalized structures for mass customization in medical fields.
32299554	5	34	theme	tissue	950:955	arg1	engineering					957:967	tissue engineering	950:967	tissue engineering	950:967	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	2	35	from	composition	312:322	arg1	resemblance					284:294	the resemblance	280:294	the resemblance of materials in composition and microstructure to biological tissues	280:363	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	2	36	theme	materials	299:307	arg1	resemblance					284:294	the resemblance	280:294	the resemblance of materials in composition and microstructure to biological tissues	280:363	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	5	37	from	application	898:908	arg1	behavior					841:848	a long-term release behavior	821:848	a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering	821:967	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	5	37	from	application	898:908	arg1	attractive					876:885	attractive	876:885	attractive	876:885	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	5	38	theme	release	918:924	arg1	application					898:908	medical application	890:908	medical application of drug release, biomedical devices and tissue engineering	890:967	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	4	39	theme	sodium	654:659	arg1	alginate					661:668	sodium alginate	654:668	sodium alginate (SA)	654:673	In this work, we showed a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls).
32299554	4	39	theme	sodium	654:659	arg1	SA					671:672	SA	671:672	SA	671:672	In this work, we showed a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls).
32299554	5	40	theme	structural	780:789	arg1	stability					791:799	structural stability	780:799	structural stability	780:799	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	4	41	theme	laponite	679:686	arg1	Xls					698:700	Xls	698:700	Xls	698:700	In this work, we showed a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls).
32299554	4	41	theme	laponite	679:686	arg1	nanoclay					688:695	laponite nanoclay	679:695	laponite nanoclay (Xls)	679:701	In this work, we showed a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls).
32299554	1	42	theme	novel	161:165	arg1	approach					167:174	a novel approach	159:174	a novel approach to manufacture repeatable personalized structures for mass customization in medical fields	159:265	Three-dimensional (3D) printing offers a novel approach to manufacture repeatable personalized structures for mass customization in medical fields.
32299554	2	43	from	microstructure	328:341	arg1	resemblance					284:294	the resemblance	280:294	the resemblance of materials in composition and microstructure to biological tissues	280:363	Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material.
32299554	4	44	theme	printing	549:556	arg1	ink					558:560	a green nanocomposite printing ink	527:560	a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls)	527:701	In this work, we showed a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls).
32299554	5	45	theme	protein	853:859	arg1	behavior					841:848	a long-term release behavior	821:848	a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering	821:967	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	5	45	theme	protein	853:859	arg1	attractive					876:885	attractive	876:885	attractive	876:885	The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
32299554	3	46	theme	long-term	443:451	arg1	problem					494:500	a problem	492:500	a problem	492:500	However, its long-term stability of structure has always been a problem.
32299554	3	46	theme	long-term	443:451	arg1	stability					453:461	its long-term stability	439:461	its long-term stability of structure	439:474	However, its long-term stability of structure has always been a problem.
32388854	11	0	from	case	1882:1885	arg1	unknown					1867:1873	unknown	1867:1873	unknown	1867:1873	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	10	1	theme	compositional	1580:1592	arg1	reasons					1512:1518	CONCLUSIONS Possible reasons	1491:1518	CONCLUSIONS Possible reasons for the great variability of pasting behaviour	1491:1565	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	10	1	theme	compositional	1580:1592	arg1	differences					1609:1619	the compositional and structural differences	1576:1619	the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans)	1576:1674	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	7	2	theme	representative	1169:1182	arg1	samples					1184:1190	two to three representative samples	1156:1190	two to three representative samples	1156:1190	From each cluster two to three representative samples were selected for wider examination using conventional testing methods.
32388854	11	3	theme	molecular	1727:1735	arg1	background					1737:1746	molecular background	1727:1746	molecular background	1727:1746	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	10	4	dep	carbohydrates	1641:1653	arg1	arabinoxylans					1661:1673	e.g. arabinoxylans	1656:1673	e.g. arabinoxylans	1656:1673	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	2	5	theme	protein	269:275	arg1	composition					277:287	Their protein composition	263:287	Their protein composition	263:287	Their protein composition and gluten dependent technological traits have been comprehensively studied, however, little information is available about their carbohydrate dependent viscous properties.
32388854	1	6	theme	recognized	160:169	arg1	variety					198:204	the internationally recognized old Hungarian Bánkúti 1201 variety	140:204	the internationally recognized old Hungarian Bánkúti 1201 variety	140:204	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety are important genetic resources for breeding programmes.
32388854	8	7	theme	pasting	1319:1325	arg1	behaviour					1327:1335	pasting behaviour	1319:1335	pasting behaviour of the lines, which can be critical for end product quality	1319:1395	These results also supported the higher variability of pasting behaviour of the lines, which can be critical for end product quality.
32388854	1	8	theme	Hungarian	175:183	arg1	variety					198:204	the internationally recognized old Hungarian Bánkúti 1201 variety	140:204	the internationally recognized old Hungarian Bánkúti 1201 variety	140:204	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety are important genetic resources for breeding programmes.
32388854	10	9	theme	carbohydrates	1641:1653	arg1	reasons					1512:1518	CONCLUSIONS Possible reasons	1491:1518	CONCLUSIONS Possible reasons for the great variability of pasting behaviour	1491:1565	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	10	9	theme	carbohydrates	1641:1653	arg1	differences					1609:1619	the compositional and structural differences	1576:1619	the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans)	1576:1674	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	0	10	theme	complex	90:96	arg1	analysis					110:117	complex rheological analysis	90:117	complex rheological analysis	90:117	A novel approach to the characterization of old wheat (Triticum aestivum L.) varieties by complex rheological analysis.
32388854	2	11	theme	dependent	300:308	arg1	traits					324:329	gluten dependent technological traits	293:329	gluten dependent technological traits	293:329	Their protein composition and gluten dependent technological traits have been comprehensively studied, however, little information is available about their carbohydrate dependent viscous properties.
32388854	5	12	theme	Cluster	873:879	arg1	analysis					881:888	Cluster analysis	873:888	Cluster analysis of the Mixolab data	873:908	Cluster analysis of the Mixolab data was performed resulting in four sample groups.
32388854	6	13	theme	mixing	988:993	arg1	properties					995:1004	similar mixing properties	980:1004	similar mixing properties	980:1004	Since several lines of similar mixing properties had significantly different pasting characteristics, it was assumed that classification was mainly based on the viscous properties.
32388854	8	14	theme	lines	1344:1348	arg1	behaviour					1327:1335	pasting behaviour	1319:1335	pasting behaviour of the lines, which can be critical for end product quality	1319:1395	These results also supported the higher variability of pasting behaviour of the lines, which can be critical for end product quality.
32388854	11	15	theme	old	1890:1892	arg1	varieties					1900:1908	old wheat varieties	1890:1908	old wheat varieties	1890:1908	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	6	16	theme	several	963:969	arg1	lines					971:975	several lines	963:975	several lines of similar mixing properties	963:1004	Since several lines of similar mixing properties had significantly different pasting characteristics, it was assumed that classification was mainly based on the viscous properties.
32388854	11	17	theme	technology	1821:1830	arg1	view					1813:1816	view	1813:1816	view	1813:1816	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	11	18	theme	view	1813:1816	arg1	point					1804:1808	the point	1800:1808	the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces	1800:1922	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	0	19	theme	wheat	48:52	arg1	characterization					24:39	the characterization	20:39	the characterization of old wheat (Triticum aestivum L.)	20:75	A novel approach to the characterization of old wheat (Triticum aestivum L.) varieties by complex rheological analysis.
32388854	3	20	theme	dependent	655:663	arg1	behaviour					673:681	the carbohydrate dependent viscous behaviour	638:681	the carbohydrate dependent viscous behaviour	638:681	The aim of this work was to obtain comprehensive rheological characterization of all sublines of Bánkúti 1201 maintained at Martonvásár and to investigate their variability if the carbohydrate dependent viscous behaviour was also included in the analyses.
32388854	11	21	from	point	1804:1808	arg1	traits					1788:1793	important traits	1778:1793	important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces	1778:1922	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	10	22	theme	CONCLUSIONS	1491:1501	arg1	reasons					1512:1518	CONCLUSIONS Possible reasons	1491:1518	CONCLUSIONS Possible reasons for the great variability of pasting behaviour	1491:1565	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	10	22	theme	CONCLUSIONS	1491:1501	arg1	differences					1609:1619	the compositional and structural differences	1576:1619	the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans)	1576:1674	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	8	23	theme	product	1381:1387	arg1	quality					1389:1395	end product quality	1377:1395	end product quality	1377:1395	These results also supported the higher variability of pasting behaviour of the lines, which can be critical for end product quality.
32388854	11	24	theme	product	1836:1842	arg1	development					1844:1854	product development	1836:1854	product development	1836:1854	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	6	25	theme	different	1024:1032	arg1	characteristics					1042:1056	significantly different pasting characteristics	1010:1056	significantly different pasting characteristics	1010:1056	Since several lines of similar mixing properties had significantly different pasting characteristics, it was assumed that classification was mainly based on the viscous properties.
32388854	12	26	theme	Chemical	1943:1950	arg1	Industry					1952:1959	Chemical Industry	1943:1959	Chemical Industry	1943:1959	© 2020 Society of Chemical Industry.
32388854	6	27	theme	viscous	1118:1124	arg1	properties					1126:1135	the viscous properties	1114:1135	the viscous properties	1114:1135	Since several lines of similar mixing properties had significantly different pasting characteristics, it was assumed that classification was mainly based on the viscous properties.
32388854	4	28	theme	mixing	780:785	arg1	quality					787:793	the famously good mixing quality	762:793	the famously good mixing quality of Bánkúti	762:804	RESULTS The majority of the lines reflected the famously good mixing quality of Bánkúti, however, much higher diversity of pasting behaviour was detected.
32388854	7	29	theme	conventional	1234:1245	arg1	methods					1255:1261	conventional testing methods	1234:1261	conventional testing methods	1234:1261	From each cluster two to three representative samples were selected for wider examination using conventional testing methods.
32388854	0	30	dep	Triticum	55:62	arg1	L.					73:74	Triticum aestivum L.	55:74	Triticum aestivum L.	55:74	A novel approach to the characterization of old wheat (Triticum aestivum L.) varieties by complex rheological analysis.
32388854	10	31	theme	pasting	1549:1555	arg1	behaviour					1557:1565	pasting behaviour	1549:1565	pasting behaviour	1549:1565	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	4	32	theme	behaviour	849:857	arg1	diversity					828:836	much higher diversity	816:836	much higher diversity of pasting behaviour	816:857	RESULTS The majority of the lines reflected the famously good mixing quality of Bánkúti, however, much higher diversity of pasting behaviour was detected.
32388854	2	33	theme	dependent	432:440	arg1	properties					450:459	their carbohydrate dependent viscous properties	413:459	their carbohydrate dependent viscous properties	413:459	Their protein composition and gluten dependent technological traits have been comprehensively studied, however, little information is available about their carbohydrate dependent viscous properties.
32388854	6	34	contain	had	1006:1008	arg1	lines					971:975	several lines	963:975	several lines of similar mixing properties	963:1004	Since several lines of similar mixing properties had significantly different pasting characteristics, it was assumed that classification was mainly based on the viscous properties.
32388854	6	34	contain	had	1006:1008	arg2	characteristics					1042:1056	significantly different pasting characteristics	1010:1056	significantly different pasting characteristics	1010:1056	Since several lines of similar mixing properties had significantly different pasting characteristics, it was assumed that classification was mainly based on the viscous properties.
32388854	11	35	theme	landraces	1914:1922	arg1	case					1882:1885	the case	1878:1885	the case of old wheat varieties and landraces	1878:1922	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	9	36	theme	second	1417:1422	arg1	cluster					1424:1430	the second cluster	1413:1430	the second cluster	1413:1430	The members of the second cluster can be highlighted due to their waxy wheat like behaviour.
32388854	4	37	theme	higher	821:826	arg1	diversity					828:836	much higher diversity	816:836	much higher diversity of pasting behaviour	816:857	RESULTS The majority of the lines reflected the famously good mixing quality of Bánkúti, however, much higher diversity of pasting behaviour was detected.
32388854	11	38	theme	varieties	1900:1908	arg1	case					1882:1885	the case	1878:1885	the case of old wheat varieties and landraces	1878:1922	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	1	39	theme	important	210:218	arg1	resources					228:236	important genetic resources	210:236	important genetic resources for breeding programmes	210:260	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety are important genetic resources for breeding programmes.
32388854	1	39	theme	important	210:218	arg1	Lines					131:135	BACKGROUND Lines	120:135	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety	120:204	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety are important genetic resources for breeding programmes.
32388854	3	40	theme	work	478:481	arg1	aim					466:468	The aim	462:468	The aim of this work	462:481	The aim of this work was to obtain comprehensive rheological characterization of all sublines of Bánkúti 1201 maintained at Martonvásár and to investigate their variability if the carbohydrate dependent viscous behaviour was also included in the analyses.
32388854	11	41	theme	rheological	1685:1695	arg1	characterization					1697:1712	Complex rheological characterization	1677:1712	Complex rheological characterization	1677:1712	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	3	42	theme	sublines	547:554	arg1	characterization					523:538	comprehensive rheological characterization	497:538	comprehensive rheological characterization of all sublines of Bánkúti 1201 maintained at Martonvásár	497:596	The aim of this work was to obtain comprehensive rheological characterization of all sublines of Bánkúti 1201 maintained at Martonvásár and to investigate their variability if the carbohydrate dependent viscous behaviour was also included in the analyses.
32388854	5	43	theme	Mixolab	897:903	arg1	data					905:908	the Mixolab data	893:908	the Mixolab data	893:908	Cluster analysis of the Mixolab data was performed resulting in four sample groups.
32388854	1	44	theme	breeding	242:249	arg1	programmes					251:260	breeding programmes	242:260	breeding programmes	242:260	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety are important genetic resources for breeding programmes.
32388854	10	45	theme	other	1635:1639	arg1	carbohydrates					1641:1653	other carbohydrates	1635:1653	other carbohydrates (e.g. arabinoxylans)	1635:1674	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	2	46	theme	gluten	293:298	arg1	traits					324:329	gluten dependent technological traits	293:329	gluten dependent technological traits	293:329	Their protein composition and gluten dependent technological traits have been comprehensively studied, however, little information is available about their carbohydrate dependent viscous properties.
32388854	9	47	theme	waxy	1464:1467	arg1	wheat					1469:1473	their waxy wheat	1458:1473	their waxy wheat like behaviour	1458:1488	The members of the second cluster can be highlighted due to their waxy wheat like behaviour.
32388854	10	48	theme	starch	1624:1629	arg1	reasons					1512:1518	CONCLUSIONS Possible reasons	1491:1518	CONCLUSIONS Possible reasons for the great variability of pasting behaviour	1491:1565	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	10	48	theme	starch	1624:1629	arg1	differences					1609:1619	the compositional and structural differences	1576:1619	the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans)	1576:1674	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	3	49	theme	rheological	511:521	arg1	characterization					523:538	comprehensive rheological characterization	497:538	comprehensive rheological characterization of all sublines of Bánkúti 1201 maintained at Martonvásár	497:596	The aim of this work was to obtain comprehensive rheological characterization of all sublines of Bánkúti 1201 maintained at Martonvásár and to investigate their variability if the carbohydrate dependent viscous behaviour was also included in the analyses.
32388854	3	50	theme	Bánkúti	559:565	arg1	sublines					547:554	all sublines	543:554	all sublines of Bánkúti 1201 maintained at Martonvásár	543:596	The aim of this work was to obtain comprehensive rheological characterization of all sublines of Bánkúti 1201 maintained at Martonvásár and to investigate their variability if the carbohydrate dependent viscous behaviour was also included in the analyses.
32388854	1	51	theme	old	171:173	arg1	variety					198:204	the internationally recognized old Hungarian Bánkúti 1201 variety	140:204	the internationally recognized old Hungarian Bánkúti 1201 variety	140:204	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety are important genetic resources for breeding programmes.
32388854	11	52	from	unknown	1867:1873	arg1	case					1882:1885	the case	1878:1885	the case of old wheat varieties and landraces	1878:1922	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	8	53	theme	higher	1297:1302	arg1	variability					1304:1314	the higher variability	1293:1314	the higher variability of pasting behaviour of the lines, which can be critical for end product quality	1293:1395	These results also supported the higher variability of pasting behaviour of the lines, which can be critical for end product quality.
32388854	11	54	theme	background	1737:1746	arg1	study					1718:1722	study	1718:1722	study	1718:1722	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	11	54	theme	background	1737:1746	arg1	characterization					1697:1712	Complex rheological characterization	1677:1712	Complex rheological characterization	1677:1712	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	5	55	theme	data	905:908	arg1	analysis					881:888	Cluster analysis	873:888	Cluster analysis of the Mixolab data	873:908	Cluster analysis of the Mixolab data was performed resulting in four sample groups.
32388854	7	56	dep	three	1163:1167	arg1	to					1160:1161	to	1160:1161	to	1160:1161	From each cluster two to three representative samples were selected for wider examination using conventional testing methods.
32388854	0	57	theme	rheological	98:108	arg1	analysis					110:117	complex rheological analysis	90:117	complex rheological analysis	90:117	A novel approach to the characterization of old wheat (Triticum aestivum L.) varieties by complex rheological analysis.
32388854	2	58	theme	technological	310:322	arg1	traits					324:329	gluten dependent technological traits	293:329	gluten dependent technological traits	293:329	Their protein composition and gluten dependent technological traits have been comprehensively studied, however, little information is available about their carbohydrate dependent viscous properties.
32388854	1	59	theme	Bánkúti	185:191	arg1	variety					198:204	the internationally recognized old Hungarian Bánkúti 1201 variety	140:204	the internationally recognized old Hungarian Bánkúti 1201 variety	140:204	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety are important genetic resources for breeding programmes.
32388854	6	60	theme	properties	995:1004	arg1	lines					971:975	several lines	963:975	several lines of similar mixing properties	963:1004	Since several lines of similar mixing properties had significantly different pasting characteristics, it was assumed that classification was mainly based on the viscous properties.
32388854	8	61	theme	behaviour	1327:1335	arg1	variability					1304:1314	the higher variability	1293:1314	the higher variability of pasting behaviour of the lines, which can be critical for end product quality	1293:1395	These results also supported the higher variability of pasting behaviour of the lines, which can be critical for end product quality.
32388854	1	62	theme	variety	198:204	arg1	resources					228:236	important genetic resources	210:236	important genetic resources for breeding programmes	210:260	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety are important genetic resources for breeding programmes.
32388854	1	62	theme	variety	198:204	arg1	Lines					131:135	BACKGROUND Lines	120:135	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety	120:204	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety are important genetic resources for breeding programmes.
32388854	6	63	theme	similar	980:986	arg1	properties					995:1004	similar mixing properties	980:1004	similar mixing properties	980:1004	Since several lines of similar mixing properties had significantly different pasting characteristics, it was assumed that classification was mainly based on the viscous properties.
32388854	11	64	theme	wheat	1894:1898	arg1	varieties					1900:1908	old wheat varieties	1890:1908	old wheat varieties	1890:1908	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	5	65	theme	sample	942:947	arg1	groups					949:954	four sample groups	937:954	four sample groups	937:954	Cluster analysis of the Mixolab data was performed resulting in four sample groups.
32388854	4	66	theme	lines	746:750	arg1	majority					730:737	The majority	726:737	The majority of the lines	726:750	RESULTS The majority of the lines reflected the famously good mixing quality of Bánkúti, however, much higher diversity of pasting behaviour was detected.
32388854	3	67	theme	viscous	665:671	arg1	behaviour					673:681	the carbohydrate dependent viscous behaviour	638:681	the carbohydrate dependent viscous behaviour	638:681	The aim of this work was to obtain comprehensive rheological characterization of all sublines of Bánkúti 1201 maintained at Martonvásár and to investigate their variability if the carbohydrate dependent viscous behaviour was also included in the analyses.
32388854	1	68	theme	BACKGROUND	120:129	arg1	resources					228:236	important genetic resources	210:236	important genetic resources for breeding programmes	210:260	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety are important genetic resources for breeding programmes.
32388854	1	68	theme	BACKGROUND	120:129	arg1	Lines					131:135	BACKGROUND Lines	120:135	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety	120:204	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety are important genetic resources for breeding programmes.
32388854	8	69	theme	end	1377:1379	arg1	quality					1389:1395	end product quality	1377:1395	end product quality	1377:1395	These results also supported the higher variability of pasting behaviour of the lines, which can be critical for end product quality.
32388854	6	70	theme	pasting	1034:1040	arg1	characteristics					1042:1056	significantly different pasting characteristics	1010:1056	significantly different pasting characteristics	1010:1056	Since several lines of similar mixing properties had significantly different pasting characteristics, it was assumed that classification was mainly based on the viscous properties.
32388854	4	71	theme	Bánkúti	798:804	arg1	quality					787:793	the famously good mixing quality	762:793	the famously good mixing quality of Bánkúti	762:804	RESULTS The majority of the lines reflected the famously good mixing quality of Bánkúti, however, much higher diversity of pasting behaviour was detected.
32388854	11	72	theme	development	1844:1854	arg1	view					1813:1816	view	1813:1816	view	1813:1816	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	7	73	theme	testing	1247:1253	arg1	methods					1255:1261	conventional testing methods	1234:1261	conventional testing methods	1234:1261	From each cluster two to three representative samples were selected for wider examination using conventional testing methods.
32388854	0	74	theme	novel	2:6	arg1	approach					8:15	A novel approach	0:15	A novel approach to the characterization of old wheat (Triticum aestivum L.)	0:75	A novel approach to the characterization of old wheat (Triticum aestivum L.) varieties by complex rheological analysis.
32388854	10	75	theme	Possible	1503:1510	arg1	reasons					1512:1518	CONCLUSIONS Possible reasons	1491:1518	CONCLUSIONS Possible reasons for the great variability of pasting behaviour	1491:1565	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	10	75	theme	Possible	1503:1510	arg1	differences					1609:1619	the compositional and structural differences	1576:1619	the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans)	1576:1674	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	4	76	theme	good	775:778	arg1	quality					787:793	the famously good mixing quality	762:793	the famously good mixing quality of Bánkúti	762:804	RESULTS The majority of the lines reflected the famously good mixing quality of Bánkúti, however, much higher diversity of pasting behaviour was detected.
32388854	7	77	theme	wider	1210:1214	arg1	examination					1216:1226	wider examination	1210:1226	wider examination using conventional testing methods	1210:1261	From each cluster two to three representative samples were selected for wider examination using conventional testing methods.
32388854	11	78	theme	important	1778:1786	arg1	traits					1788:1793	important traits	1778:1793	important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces	1778:1922	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	2	79	theme	viscous	442:448	arg1	properties					450:459	their carbohydrate dependent viscous properties	413:459	their carbohydrate dependent viscous properties	413:459	Their protein composition and gluten dependent technological traits have been comprehensively studied, however, little information is available about their carbohydrate dependent viscous properties.
32388854	10	80	theme	great	1528:1532	arg1	variability					1534:1544	the great variability	1524:1544	the great variability of pasting behaviour	1524:1565	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	4	81	theme	pasting	841:847	arg1	behaviour					849:857	pasting behaviour	841:857	pasting behaviour	841:857	RESULTS The majority of the lines reflected the famously good mixing quality of Bánkúti, however, much higher diversity of pasting behaviour was detected.
32388854	2	82	theme	carbohydrate	419:430	arg1	properties					450:459	their carbohydrate dependent viscous properties	413:459	their carbohydrate dependent viscous properties	413:459	Their protein composition and gluten dependent technological traits have been comprehensively studied, however, little information is available about their carbohydrate dependent viscous properties.
32388854	0	83	theme	old	44:46	arg1	Triticum					55:62	Triticum	55:62	Triticum	55:62	A novel approach to the characterization of old wheat (Triticum aestivum L.) varieties by complex rheological analysis.
32388854	0	83	theme	old	44:46	arg1	wheat					48:52	old wheat	44:52	old wheat (Triticum aestivum L.)	44:75	A novel approach to the characterization of old wheat (Triticum aestivum L.) varieties by complex rheological analysis.
32388854	9	84	theme	cluster	1424:1430	arg1	members					1402:1408	The members	1398:1408	The members of the second cluster	1398:1430	The members of the second cluster can be highlighted due to their waxy wheat like behaviour.
32388854	4	85	dep	RESULTS	718:724	arg1	reflected					752:760	reflected	752:760	reflected the famously good mixing quality of Bánkúti	752:804	RESULTS The majority of the lines reflected the famously good mixing quality of Bánkúti, however, much higher diversity of pasting behaviour was detected.
32388854	10	86	theme	behaviour	1557:1565	arg1	variability					1534:1544	the great variability	1524:1544	the great variability of pasting behaviour	1524:1565	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	11	87	theme	Complex	1677:1683	arg1	characterization					1697:1712	Complex rheological characterization	1677:1712	Complex rheological characterization	1677:1712	Complex rheological characterization and study of molecular background can provide information about important traits from the point of view of technology and product development, which are unknown in the case of old wheat varieties and landraces.
32388854	3	88	theme	comprehensive	497:509	arg1	characterization					523:538	comprehensive rheological characterization	497:538	comprehensive rheological characterization of all sublines of Bánkúti 1201 maintained at Martonvásár	497:596	The aim of this work was to obtain comprehensive rheological characterization of all sublines of Bánkúti 1201 maintained at Martonvásár and to investigate their variability if the carbohydrate dependent viscous behaviour was also included in the analyses.
32388854	1	89	theme	genetic	220:226	arg1	resources					228:236	important genetic resources	210:236	important genetic resources for breeding programmes	210:260	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety are important genetic resources for breeding programmes.
32388854	1	89	theme	genetic	220:226	arg1	Lines					131:135	BACKGROUND Lines	120:135	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety	120:204	BACKGROUND Lines of the internationally recognized old Hungarian Bánkúti 1201 variety are important genetic resources for breeding programmes.
32388854	10	90	theme	structural	1598:1607	arg1	reasons					1512:1518	CONCLUSIONS Possible reasons	1491:1518	CONCLUSIONS Possible reasons for the great variability of pasting behaviour	1491:1565	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	10	90	theme	structural	1598:1607	arg1	differences					1609:1619	the compositional and structural differences	1576:1619	the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans)	1576:1674	CONCLUSIONS Possible reasons for the great variability of pasting behaviour could be the compositional and structural differences of starch and other carbohydrates (e.g. arabinoxylans).
32388854	2	91	theme	little	375:380	arg1	information					382:392	little information	375:392	little information	375:392	Their protein composition and gluten dependent technological traits have been comprehensively studied, however, little information is available about their carbohydrate dependent viscous properties.
32351134	5	0	theme	cellulose	777:785	arg1	MCEG					794:797	MCEG	794:797	MCEG	794:797	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	5	0	theme	cellulose	777:785	arg1	group					787:791	the medium-dose cellulose group	761:791	the medium-dose cellulose group (MCEG)	761:798	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	7	1	theme	HCEG	1159:1162	arg1	serum					1110:1114	the serum	1106:1114	the serum of the low-dose cellulose group, MCEG, and HCEG	1106:1162	Additionally, levels of inflammatory mediators involved in colorectal carcinogenesis, such as IL-6, IL-1β, and TNF-α, were lower in the serum of the low-dose cellulose group, MCEG, and HCEG when compared with the MG (P < 0.05).
32351134	6	2	from	flora	939:943	arg1	mice					968:971	AOM/DSS-treated CRC mice	948:971	AOM/DSS-treated CRC mice	948:971	Cellulose supplementation stimulated shifts in the intestinal flora in AOM/DSS-treated CRC mice.
32351134	0	3	from	Effects	4:10	arg1	Mice					70:73	AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice	28:73	AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice	28:73	The Effects of Cellulose on AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice by Changing Intestinal Flora Composition and Inflammatory Factors.
32351134	0	4	theme	Flora	98:102	arg1	Composition					104:114	Intestinal Flora Composition	87:114	Intestinal Flora Composition	87:114	The Effects of Cellulose on AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice by Changing Intestinal Flora Composition and Inflammatory Factors.
32351134	3	5	dep	flora	455:459	arg1	composition					461:471	composition	461:471	composition	461:471	In the present study, we investigated the regulatory effects of cellulose on intestinal flora composition and colorectal carcinogenesis in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model.
32351134	8	6	dep	correlated	1253:1262	arg1	Whereas					1202:1208	Whereas	1202:1208	Whereas	1202:1208	Whereas the abundance of differential bacteria was correlated with the concentration of IL-6, IL-1β, and TNF-α.
32351134	4	7	theme	AOM/DSS-treated	672:686	arg1	mice					692:695	AOM/DSS-treated CRC mice	672:695	AOM/DSS-treated CRC mice	672:695	Supplementation of cellulose significantly attenuated inflammation and tumor formation in AOM/DSS-treated CRC mice.
32351134	0	8	theme	Intestinal	87:96	arg1	Composition					104:114	Intestinal Flora Composition	87:114	Intestinal Flora Composition	87:114	The Effects of Cellulose on AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice by Changing Intestinal Flora Composition and Inflammatory Factors.
32351134	2	9	theme	inflammatory	278:289	arg1	factors					291:297	increased inflammatory factors	268:297	increased inflammatory factors which promote tumorigenesis and cellulose can be beneficial to CRC	268:364	It is known that microbial dysbiosis induces increased inflammatory factors which promote tumorigenesis and cellulose can be beneficial to CRC.
32351134	8	10	theme	differential	1227:1238	arg1	bacteria					1240:1247	differential bacteria	1227:1247	differential bacteria	1227:1247	Whereas the abundance of differential bacteria was correlated with the concentration of IL-6, IL-1β, and TNF-α.
32351134	9	11	theme	colon	1403:1407	arg1	inflammation					1409:1420	colon inflammation	1403:1420	colon inflammation	1403:1420	These results showed cellulose changed the composition of intestinal flora and inhibited colon inflammation and neoplasm formation caused by the AOM/DSS treatment.
32351134	2	12	theme	increased	268:276	arg1	factors					291:297	increased inflammatory factors	268:297	increased inflammatory factors which promote tumorigenesis and cellulose can be beneficial to CRC	268:364	It is known that microbial dysbiosis induces increased inflammatory factors which promote tumorigenesis and cellulose can be beneficial to CRC.
32351134	1	13	theme	key	179:181	arg1	factor					188:193	a key risk factor	177:193	a key risk factor of colorectal cancer (CRC)	177:220	Chronic intestinal inflammation is a key risk factor of colorectal cancer (CRC).
32351134	1	13	theme	key	179:181	arg1	inflammation					161:172	Chronic intestinal inflammation	142:172	Chronic intestinal inflammation	142:172	Chronic intestinal inflammation is a key risk factor of colorectal cancer (CRC).
32351134	7	14	theme	MCEG	1149:1152	arg1	serum					1110:1114	the serum	1106:1114	the serum of the low-dose cellulose group, MCEG, and HCEG	1106:1162	Additionally, levels of inflammatory mediators involved in colorectal carcinogenesis, such as IL-6, IL-1β, and TNF-α, were lower in the serum of the low-dose cellulose group, MCEG, and HCEG when compared with the MG (P < 0.05).
32351134	7	15	theme	group	1142:1146	arg1	serum					1110:1114	the serum	1106:1114	the serum of the low-dose cellulose group, MCEG, and HCEG	1106:1162	Additionally, levels of inflammatory mediators involved in colorectal carcinogenesis, such as IL-6, IL-1β, and TNF-α, were lower in the serum of the low-dose cellulose group, MCEG, and HCEG when compared with the MG (P < 0.05).
32351134	1	16	theme	risk	183:186	arg1	factor					188:193	a key risk factor	177:193	a key risk factor of colorectal cancer (CRC)	177:220	Chronic intestinal inflammation is a key risk factor of colorectal cancer (CRC).
32351134	1	16	theme	risk	183:186	arg1	inflammation					161:172	Chronic intestinal inflammation	142:172	Chronic intestinal inflammation	142:172	Chronic intestinal inflammation is a key risk factor of colorectal cancer (CRC).
32351134	5	17	theme	high-dose	804:812	arg1	HCEG					831:834	HCEG	831:834	HCEG	831:834	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	5	17	theme	high-dose	804:812	arg1	group					824:828	high-dose cellulose group	804:828	high-dose cellulose group (HCEG)	804:835	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	3	18	theme	-induced	556:563	arg1	model					575:579	an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model	506:579	an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model	506:579	In the present study, we investigated the regulatory effects of cellulose on intestinal flora composition and colorectal carcinogenesis in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model.
32351134	9	19	theme	flora	1383:1387	arg1	composition					1357:1367	the composition	1353:1367	the composition of intestinal flora	1353:1387	These results showed cellulose changed the composition of intestinal flora and inhibited colon inflammation and neoplasm formation caused by the AOM/DSS treatment.
32351134	5	20	theme	cellulose	814:822	arg1	HCEG					831:834	HCEG	831:834	HCEG	831:834	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	5	20	theme	cellulose	814:822	arg1	group					824:828	high-dose cellulose group	804:828	high-dose cellulose group (HCEG)	804:835	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	6	21	theme	CRC	964:966	arg1	mice					968:971	AOM/DSS-treated CRC mice	948:971	AOM/DSS-treated CRC mice	948:971	Cellulose supplementation stimulated shifts in the intestinal flora in AOM/DSS-treated CRC mice.
32351134	3	22	theme	CRC	565:567	arg1	model					575:579	an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model	506:579	an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model	506:579	In the present study, we investigated the regulatory effects of cellulose on intestinal flora composition and colorectal carcinogenesis in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model.
32351134	4	23	from	formation	659:667	arg1	mice					692:695	AOM/DSS-treated CRC mice	672:695	AOM/DSS-treated CRC mice	672:695	Supplementation of cellulose significantly attenuated inflammation and tumor formation in AOM/DSS-treated CRC mice.
32351134	4	24	theme	CRC	688:690	arg1	mice					692:695	AOM/DSS-treated CRC mice	672:695	AOM/DSS-treated CRC mice	672:695	Supplementation of cellulose significantly attenuated inflammation and tumor formation in AOM/DSS-treated CRC mice.
32351134	0	25	theme	Cellulose	15:23	arg1	Effects					4:10	The Effects	0:10	The Effects of Cellulose on AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice	0:73	The Effects of Cellulose on AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice by Changing Intestinal Flora Composition and Inflammatory Factors.
32351134	6	26	theme	AOM/DSS-treated	948:962	arg1	mice					968:971	AOM/DSS-treated CRC mice	948:971	AOM/DSS-treated CRC mice	948:971	Cellulose supplementation stimulated shifts in the intestinal flora in AOM/DSS-treated CRC mice.
32351134	5	27	dep	MG	862:863	arg1	P < 0.05					866:873	P < 0.05	866:873	MG; P < 0.05	862:873	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	1	28	theme	colorectal	198:207	arg1	cancer					209:214	colorectal cancer	198:214	colorectal cancer (CRC)	198:220	Chronic intestinal inflammation is a key risk factor of colorectal cancer (CRC).
32351134	1	28	theme	colorectal	198:207	arg1	CRC					217:219	CRC	217:219	CRC	217:219	Chronic intestinal inflammation is a key risk factor of colorectal cancer (CRC).
32351134	3	29	theme	present	374:380	arg1	study					382:386	the present study	370:386	the present study	370:386	In the present study, we investigated the regulatory effects of cellulose on intestinal flora composition and colorectal carcinogenesis in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model.
32351134	0	30	theme	Inflammatory	120:131	arg1	Factors					133:139	Inflammatory Factors	120:139	Inflammatory Factors	120:139	The Effects of Cellulose on AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice by Changing Intestinal Flora Composition and Inflammatory Factors.
32351134	1	31	theme	cancer	209:214	arg1	factor					188:193	a key risk factor	177:193	a key risk factor of colorectal cancer (CRC)	177:220	Chronic intestinal inflammation is a key risk factor of colorectal cancer (CRC).
32351134	1	31	theme	cancer	209:214	arg1	inflammation					161:172	Chronic intestinal inflammation	142:172	Chronic intestinal inflammation	142:172	Chronic intestinal inflammation is a key risk factor of colorectal cancer (CRC).
32351134	0	32	theme	AOM/DSS-Treated	28:42	arg1	Mice					70:73	AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice	28:73	AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice	28:73	The Effects of Cellulose on AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice by Changing Intestinal Flora Composition and Inflammatory Factors.
32351134	5	33	theme	tumor	724:728	arg1	higher					751:756	higher	751:756	higher	751:756	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	5	33	theme	tumor	724:728	arg1	rate					741:744	the tumor inhibition rate	720:744	the tumor inhibition rate	720:744	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	9	34	dep	showed	1328:1333	arg1	changed					1345:1351	changed	1345:1351	changed the composition of intestinal flora	1345:1387	These results showed cellulose changed the composition of intestinal flora and inhibited colon inflammation and neoplasm formation caused by the AOM/DSS treatment.
32351134	9	34	dep	showed	1328:1333	arg1	inhibited					1393:1401	inhibited	1393:1401	inhibited colon inflammation and neoplasm formation caused by the AOM/DSS treatment	1393:1475	These results showed cellulose changed the composition of intestinal flora and inhibited colon inflammation and neoplasm formation caused by the AOM/DSS treatment.
32351134	5	35	theme	inhibition	730:739	arg1	higher					751:756	higher	751:756	higher	751:756	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	5	35	theme	inhibition	730:739	arg1	rate					741:744	the tumor inhibition rate	720:744	the tumor inhibition rate	720:744	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	4	36	from	inflammation	636:647	arg1	mice					692:695	AOM/DSS-treated CRC mice	672:695	AOM/DSS-treated CRC mice	672:695	Supplementation of cellulose significantly attenuated inflammation and tumor formation in AOM/DSS-treated CRC mice.
32351134	3	37	theme	intestinal	444:453	arg1	flora					455:459	intestinal flora composition and colorectal carcinogenesis	444:501	flora	455:459	In the present study, we investigated the regulatory effects of cellulose on intestinal flora composition and colorectal carcinogenesis in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model.
32351134	3	38	theme	cellulose	431:439	arg1	effects					420:426	the regulatory effects	405:426	the regulatory effects of cellulose on intestinal flora composition and colorectal carcinogenesis	405:501	In the present study, we investigated the regulatory effects of cellulose on intestinal flora composition and colorectal carcinogenesis in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model.
32351134	6	39	theme	intestinal	928:937	arg1	flora					939:943	the intestinal flora	924:943	the intestinal flora in AOM/DSS-treated CRC mice	924:971	Cellulose supplementation stimulated shifts in the intestinal flora in AOM/DSS-treated CRC mice.
32351134	3	40	theme	regulatory	409:418	arg1	effects					420:426	the regulatory effects	405:426	the regulatory effects of cellulose on intestinal flora composition and colorectal carcinogenesis	405:501	In the present study, we investigated the regulatory effects of cellulose on intestinal flora composition and colorectal carcinogenesis in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model.
32351134	7	41	theme	inflammatory	998:1009	arg1	IL-6					1068:1071	IL-6	1068:1071	IL-6	1068:1071	Additionally, levels of inflammatory mediators involved in colorectal carcinogenesis, such as IL-6, IL-1β, and TNF-α, were lower in the serum of the low-dose cellulose group, MCEG, and HCEG when compared with the MG (P < 0.05).
32351134	7	41	theme	inflammatory	998:1009	arg1	IL-1β					1074:1078	IL-1β	1074:1078	IL-1β	1074:1078	Additionally, levels of inflammatory mediators involved in colorectal carcinogenesis, such as IL-6, IL-1β, and TNF-α, were lower in the serum of the low-dose cellulose group, MCEG, and HCEG when compared with the MG (P < 0.05).
32351134	7	41	theme	inflammatory	998:1009	arg1	TNF-α					1085:1089	TNF-α	1085:1089	TNF-α	1085:1089	Additionally, levels of inflammatory mediators involved in colorectal carcinogenesis, such as IL-6, IL-1β, and TNF-α, were lower in the serum of the low-dose cellulose group, MCEG, and HCEG when compared with the MG (P < 0.05).
32351134	7	41	theme	inflammatory	998:1009	arg1	mediators					1011:1019	inflammatory mediators	998:1019	inflammatory mediators	998:1019	Additionally, levels of inflammatory mediators involved in colorectal carcinogenesis, such as IL-6, IL-1β, and TNF-α, were lower in the serum of the low-dose cellulose group, MCEG, and HCEG when compared with the MG (P < 0.05).
32351134	4	42	theme	tumor	653:657	arg1	formation					659:667	tumor formation	653:667	tumor formation	653:667	Supplementation of cellulose significantly attenuated inflammation and tumor formation in AOM/DSS-treated CRC mice.
32351134	0	43	theme	Colorectal	52:61	arg1	Mice					70:73	AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice	28:73	AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice	28:73	The Effects of Cellulose on AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice by Changing Intestinal Flora Composition and Inflammatory Factors.
32351134	9	44	theme	intestinal	1372:1381	arg1	flora					1383:1387	intestinal flora	1372:1387	intestinal flora	1372:1387	These results showed cellulose changed the composition of intestinal flora and inhibited colon inflammation and neoplasm formation caused by the AOM/DSS treatment.
32351134	7	45	theme	colorectal	1033:1042	arg1	carcinogenesis					1044:1057	colorectal carcinogenesis	1033:1057	colorectal carcinogenesis	1033:1057	Additionally, levels of inflammatory mediators involved in colorectal carcinogenesis, such as IL-6, IL-1β, and TNF-α, were lower in the serum of the low-dose cellulose group, MCEG, and HCEG when compared with the MG (P < 0.05).
32351134	5	46	theme	medium-dose	765:775	arg1	MCEG					794:797	MCEG	794:797	MCEG	794:797	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	5	46	theme	medium-dose	765:775	arg1	group					787:791	the medium-dose cellulose group	761:791	the medium-dose cellulose group (MCEG)	761:798	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	3	47	theme	mouse	569:573	arg1	model					575:579	an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model	506:579	an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model	506:579	In the present study, we investigated the regulatory effects of cellulose on intestinal flora composition and colorectal carcinogenesis in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model.
32351134	7	48	theme	mediators	1011:1019	arg1	levels					988:993	levels	988:993	levels of inflammatory mediators involved in colorectal carcinogenesis, such as IL-6, IL-1β, and TNF-α,	988:1090	Additionally, levels of inflammatory mediators involved in colorectal carcinogenesis, such as IL-6, IL-1β, and TNF-α, were lower in the serum of the low-dose cellulose group, MCEG, and HCEG when compared with the MG (P < 0.05).
32351134	9	49	theme	neoplasm	1426:1433	arg1	formation					1435:1443	neoplasm formation	1426:1443	neoplasm formation	1426:1443	These results showed cellulose changed the composition of intestinal flora and inhibited colon inflammation and neoplasm formation caused by the AOM/DSS treatment.
32351134	0	50	theme	C57BL/6	44:50	arg1	Mice					70:73	AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice	28:73	AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice	28:73	The Effects of Cellulose on AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice by Changing Intestinal Flora Composition and Inflammatory Factors.
32351134	6	51	theme	Cellulose	877:885	arg1	supplementation					887:901	Cellulose supplementation	877:901	Cellulose supplementation	877:901	Cellulose supplementation stimulated shifts in the intestinal flora in AOM/DSS-treated CRC mice.
32351134	5	52	theme	survival	702:709	arg1	higher					751:756	higher	751:756	higher	751:756	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	5	52	theme	survival	702:709	arg1	rate					711:714	The survival rate	698:714	The survival rate	698:714	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	8	53	theme	IL-1β	1296:1300	arg1	concentration					1273:1285	the concentration	1269:1285	the concentration of IL-6, IL-1β, and TNF-α	1269:1311	Whereas the abundance of differential bacteria was correlated with the concentration of IL-6, IL-1β, and TNF-α.
32351134	9	54	theme	AOM/DSS	1459:1465	arg1	treatment					1467:1475	the AOM/DSS treatment	1455:1475	the AOM/DSS treatment	1455:1475	These results showed cellulose changed the composition of intestinal flora and inhibited colon inflammation and neoplasm formation caused by the AOM/DSS treatment.
32351134	3	55	theme	colorectal	477:486	arg1	carcinogenesis					488:501	colorectal carcinogenesis	477:501	colorectal carcinogenesis	477:501	In the present study, we investigated the regulatory effects of cellulose on intestinal flora composition and colorectal carcinogenesis in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model.
32351134	8	56	theme	TNF-α	1307:1311	arg1	concentration					1273:1285	the concentration	1269:1285	the concentration of IL-6, IL-1β, and TNF-α	1269:1311	Whereas the abundance of differential bacteria was correlated with the concentration of IL-6, IL-1β, and TNF-α.
32351134	4	57	theme	cellulose	601:609	arg1	Supplementation					582:596	Supplementation	582:596	Supplementation of cellulose	582:609	Supplementation of cellulose significantly attenuated inflammation and tumor formation in AOM/DSS-treated CRC mice.
32351134	8	58	theme	IL-6	1290:1293	arg1	concentration					1273:1285	the concentration	1269:1285	the concentration of IL-6, IL-1β, and TNF-α	1269:1311	Whereas the abundance of differential bacteria was correlated with the concentration of IL-6, IL-1β, and TNF-α.
32351134	2	59	theme	microbial	240:248	arg1	dysbiosis					250:258	microbial dysbiosis	240:258	microbial dysbiosis	240:258	It is known that microbial dysbiosis induces increased inflammatory factors which promote tumorigenesis and cellulose can be beneficial to CRC.
32351134	3	60	from	effects	420:426	arg1	flora					455:459	intestinal flora composition and colorectal carcinogenesis	444:501	flora	455:459	In the present study, we investigated the regulatory effects of cellulose on intestinal flora composition and colorectal carcinogenesis in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model.
32351134	3	60	from	effects	420:426	arg1	carcinogenesis					488:501	colorectal carcinogenesis	477:501	colorectal carcinogenesis	477:501	In the present study, we investigated the regulatory effects of cellulose on intestinal flora composition and colorectal carcinogenesis in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mouse model.
32351134	1	61	theme	Chronic	142:148	arg1	factor					188:193	a key risk factor	177:193	a key risk factor of colorectal cancer (CRC)	177:220	Chronic intestinal inflammation is a key risk factor of colorectal cancer (CRC).
32351134	1	61	theme	Chronic	142:148	arg1	inflammation					161:172	Chronic intestinal inflammation	142:172	Chronic intestinal inflammation	142:172	Chronic intestinal inflammation is a key risk factor of colorectal cancer (CRC).
32351134	8	62	theme	bacteria	1240:1247	arg1	abundance					1214:1222	the abundance	1210:1222	the abundance of differential bacteria	1210:1247	Whereas the abundance of differential bacteria was correlated with the concentration of IL-6, IL-1β, and TNF-α.
32351134	1	63	theme	intestinal	150:159	arg1	factor					188:193	a key risk factor	177:193	a key risk factor of colorectal cancer (CRC)	177:220	Chronic intestinal inflammation is a key risk factor of colorectal cancer (CRC).
32351134	1	63	theme	intestinal	150:159	arg1	inflammation					161:172	Chronic intestinal inflammation	142:172	Chronic intestinal inflammation	142:172	Chronic intestinal inflammation is a key risk factor of colorectal cancer (CRC).
32351134	5	64	theme	model	849:853	arg1	MG					862:863	MG	862:863	MG; P < 0.05	862:873	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	5	64	theme	model	849:853	arg1	group					855:859	the model group	845:859	the model group (MG; P < 0.05)	845:874	The survival rate and the tumor inhibition rate were higher in the medium-dose cellulose group (MCEG) and high-dose cellulose group (HCEG) than in the model group (MG; P < 0.05).
32351134	0	65	theme	Cancer	63:68	arg1	Mice					70:73	AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice	28:73	AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice	28:73	The Effects of Cellulose on AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice by Changing Intestinal Flora Composition and Inflammatory Factors.
32351134	7	66	theme	low-dose	1123:1130	arg1	group					1142:1146	the low-dose cellulose group	1119:1146	the low-dose cellulose group	1119:1146	Additionally, levels of inflammatory mediators involved in colorectal carcinogenesis, such as IL-6, IL-1β, and TNF-α, were lower in the serum of the low-dose cellulose group, MCEG, and HCEG when compared with the MG (P < 0.05).
32351134	7	67	theme	cellulose	1132:1140	arg1	group					1142:1146	the low-dose cellulose group	1119:1146	the low-dose cellulose group	1119:1146	Additionally, levels of inflammatory mediators involved in colorectal carcinogenesis, such as IL-6, IL-1β, and TNF-α, were lower in the serum of the low-dose cellulose group, MCEG, and HCEG when compared with the MG (P < 0.05).
34152124	4	0	theme	corrosion	876:884	arg1	stability					886:894	improved corrosion stability	867:894	improved corrosion stability	867:894	Both ACP/TiO2 and ACP + ChOL/TiO2 have improved corrosion stability, whereas the ACP + ChOL/TiO2 coating showed better corrosion stability.
34152124	1	1	from	ACP	484:486	arg1	substrate					531:539	the titanium substrate	518:539	the titanium substrate	518:539	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	10	2	dep	ChOL	1839:1842	arg1	leading					1949:1955	leading	1949:1955	leading to bacterial death	1949:1974	The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
34152124	10	2	dep	ChOL	1839:1842	arg1	inhibiting					1874:1883	inhibiting	1874:1883	inhibiting its growth	1874:1894	The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
34152124	10	2	dep	ChOL	1839:1842	arg1	altering					1897:1904	altering	1897:1904	altering the permeability of the cell membrane	1897:1942	The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
34152124	6	3	theme	coating	1267:1273	arg1	formation					1223:1231	the formation	1219:1231	the formation of strongly bonded uniform stable coating with high corrosion resistance	1219:1304	This deposition mechanism resulted in the formation of strongly bonded uniform stable coating with high corrosion resistance.
34152124	9	4	theme	antibacterial	1622:1634	arg1	activity					1636:1643	no antibacterial activity	1619:1643	no antibacterial activity	1619:1643	While ACP/TiO2 shows no antibacterial activity, ACP + ChOL/TiO2 samples exhibited three- to fourfold decreases in the number of Staphylococcus aureus and Pseudomonas aeruginosa, respectively, after 420 min.
34152124	3	5	theme	thick	751:755	arg1	±					743:743	300 ±	739:743	300 ± 15 μm thick	739:755	The obtained coatings were around 300 ± 15 μm thick and consisted of two phases, namely, TiO2 and hybrid composite phases.
34152124	6	6	theme	uniform	1252:1258	arg1	coating					1267:1273	strongly bonded uniform stable coating	1236:1273	strongly bonded uniform stable coating with high corrosion resistance	1236:1304	This deposition mechanism resulted in the formation of strongly bonded uniform stable coating with high corrosion resistance.
34152124	0	7	with	Titanium	111:118	arg1	Resistance					144:153	Advanced Corrosion Resistance	125:153	Advanced Corrosion Resistance	125:153	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.
34152124	0	7	with	Titanium	111:118	arg1	Properties					187:196	Antibacterial Properties	173:196	Antibacterial Properties	173:196	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.
34152124	0	7	with	Titanium	111:118	arg1	Bioactivity					156:166	Bioactivity	156:166	Bioactivity	156:166	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.
34152124	1	8	theme	nano-amorphous	311:324	arg1	ACP					345:347	ACP	345:347	ACP	345:347	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	1	8	theme	nano-amorphous	311:324	arg1	phosphate					334:342	novel nano-amorphous calcium phosphate	305:342	novel nano-amorphous calcium phosphate (ACP)	305:348	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	1	9	theme	work	215:218	arg1	aim					203:205	The aim	199:205	The aim of this work	199:218	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	2	10	theme	anaphoretic	650:660	arg1	process					680:686	the anaphoretic electrodeposition process	646:686	the anaphoretic electrodeposition process of ACP and ChOL	646:702	The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL.
34152124	7	11	theme	body	1386:1389	arg1	SBF					1398:1400	SBF	1398:1400	SBF	1398:1400	In vitro bioactivity was investigated by immersion of the samples in simulated body fluid (SBF).
34152124	7	11	theme	body	1386:1389	arg1	fluid					1391:1395	simulated body fluid	1376:1395	simulated body fluid (SBF)	1376:1401	In vitro bioactivity was investigated by immersion of the samples in simulated body fluid (SBF).
34152124	10	12	theme	cell	1930:1933	arg1	membrane					1935:1942	the cell membrane	1926:1942	the cell membrane	1926:1942	The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
34152124	8	13	dep	Fourier	1557:1563	arg1	transform					1565:1573	transform	1565:1573	transform infrared spectroscopy	1565:1595	There is in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy.
34152124	1	14	theme	corrosion	239:247	arg1	resistivity					249:259	corrosion resistivity	239:259	corrosion resistivity	239:259	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	4	15	theme	better	940:945	arg1	stability					957:965	better corrosion stability	940:965	better corrosion stability	940:965	Both ACP/TiO2 and ACP + ChOL/TiO2 have improved corrosion stability, whereas the ACP + ChOL/TiO2 coating showed better corrosion stability.
34152124	8	16	theme	in-bone-like	1413:1424	arg1	formation					1434:1442	in-bone-like apatite formation	1413:1442	in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy	1413:1595	There is in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy.
34152124	10	17	theme	bacterial	1960:1968	arg1	death					1970:1974	bacterial death	1960:1974	bacterial death	1960:1974	The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
34152124	0	18	theme	Antibacterial	173:185	arg1	Properties					187:196	Antibacterial Properties	173:196	Antibacterial Properties	173:196	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.
34152124	2	19	theme	substrate	615:623	arg1	anodization					596:606	new single-step in situ anodization	572:606	new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL	572:702	The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL.
34152124	5	20	theme	simultaneous	1152:1163	arg1	growth					1165:1170	simultaneous growth	1152:1170	simultaneous growth of TiO2	1152:1178	It was shown that at the very start of the deposition process, the formation of the ChOL/TiO2 layer takes place predominantly, which is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2.
34152124	6	21	theme	deposition	1186:1195	arg1	mechanism					1197:1205	This deposition mechanism	1181:1205	This deposition mechanism	1181:1205	This deposition mechanism resulted in the formation of strongly bonded uniform stable coating with high corrosion resistance.
34152124	3	22	theme	composite	810:818	arg1	phases					820:825	hybrid composite phases	803:825	hybrid composite phases	803:825	The obtained coatings were around 300 ± 15 μm thick and consisted of two phases, namely, TiO2 and hybrid composite phases.
34152124	3	22	theme	composite	810:818	arg1	phases					778:783	two phases	774:783	two phases	774:783	The obtained coatings were around 300 ± 15 μm thick and consisted of two phases, namely, TiO2 and hybrid composite phases.
34152124	6	23	theme	high	1280:1283	arg1	resistance					1295:1304	high corrosion resistance	1280:1304	high corrosion resistance	1280:1304	This deposition mechanism resulted in the formation of strongly bonded uniform stable coating with high corrosion resistance.
34152124	8	24	from	formation	1434:1442	arg1	surfaces					1481:1488	both ACP/TiO2 and ACP + ChOL/TiO2 surfaces	1447:1488	surfaces	1481:1488	There is in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy.
34152124	8	24	from	formation	1434:1442	arg1	ACP/TiO2					1452:1459	both ACP/TiO2 and ACP + ChOL/TiO2 surfaces	1447:1488	ACP/TiO2	1452:1459	There is in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy.
34152124	8	24	from	formation	1434:1442	arg1	ACP					1465:1467	both ACP/TiO2 and ACP + ChOL/TiO2 surfaces	1447:1488	ACP	1465:1467	There is in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy.
34152124	1	25	from	ChOL/TiO2	461:469	arg1	substrate					531:539	the titanium substrate	518:539	the titanium substrate	518:539	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	9	26	from	decreases	1699:1707	arg1	number					1716:1721	the number	1712:1721	the number of Staphylococcus aureus and Pseudomonas aeruginosa	1712:1773	While ACP/TiO2 shows no antibacterial activity, ACP + ChOL/TiO2 samples exhibited three- to fourfold decreases in the number of Staphylococcus aureus and Pseudomonas aeruginosa, respectively, after 420 min.
34152124	9	27	theme	aeruginosa	1764:1773	arg1	number					1716:1721	the number	1712:1721	the number of Staphylococcus aureus and Pseudomonas aeruginosa	1712:1773	While ACP/TiO2 shows no antibacterial activity, ACP + ChOL/TiO2 samples exhibited three- to fourfold decreases in the number of Staphylococcus aureus and Pseudomonas aeruginosa, respectively, after 420 min.
34152124	0	28	theme	Corrosion	134:142	arg1	Resistance					144:153	Advanced Corrosion Resistance	125:153	Advanced Corrosion Resistance	125:153	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.
34152124	1	29	theme	chitosan	414:421	arg1	ChOL					448:451	ChOL	448:451	ChOL	448:451	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	1	29	theme	chitosan	414:421	arg1	lactate					439:445	chitosan oligosaccharide lactate	414:445	chitosan oligosaccharide lactate (ChOL)	414:452	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	7	30	from	immersion	1348:1356	arg1	SBF					1398:1400	SBF	1398:1400	SBF	1398:1400	In vitro bioactivity was investigated by immersion of the samples in simulated body fluid (SBF).
34152124	7	30	from	immersion	1348:1356	arg1	fluid					1391:1395	simulated body fluid	1376:1395	simulated body fluid (SBF)	1376:1401	In vitro bioactivity was investigated by immersion of the samples in simulated body fluid (SBF).
34152124	0	31	theme	Anodizing/Anaphoretic	0:20	arg1	Electrodeposition					22:38	Anodizing/Anaphoretic Electrodeposition	0:38	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.	0:197	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.
34152124	1	32	theme	calcium	326:332	arg1	ACP					345:347	ACP	345:347	ACP	345:347	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	1	32	theme	calcium	326:332	arg1	phosphate					334:342	novel nano-amorphous calcium phosphate	305:342	novel nano-amorphous calcium phosphate (ACP)	305:348	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	0	33	theme	Phosphate/Chitosan	56:73	arg1	Coatings					99:106	Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings	43:106	Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings	43:106	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.
34152124	5	34	theme	deposition	1011:1020	arg1	process					1022:1028	the deposition process	1007:1028	the deposition process	1007:1028	It was shown that at the very start of the deposition process, the formation of the ChOL/TiO2 layer takes place predominantly, which is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2.
34152124	8	35	theme	X-ray	1535:1539	arg1	diffraction					1541:1551	X-ray diffraction	1535:1551	X-ray diffraction	1535:1551	There is in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy.
34152124	10	36	theme	binding	1831:1837	arg1	mechanism					1818:1826	The probable mechanism	1805:1826	The probable mechanism	1805:1826	The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
34152124	10	36	theme	binding	1831:1837	arg1	ChOL					1839:1842	binding ChOL	1831:1842	binding ChOL with the bacterial cell wall	1831:1871	The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
34152124	0	37	theme	Multifunctional	83:97	arg1	Coatings					99:106	Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings	43:106	Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings	43:106	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.
34152124	1	38	theme	multifunctional	362:376	arg1	coatings					388:395	potentially multifunctional composite coatings	350:395	potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate	350:539	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	9	39	theme	ChOL/TiO2	1652:1660	arg1	samples					1662:1668	ACP + ChOL/TiO2 samples	1646:1668	ACP + ChOL/TiO2 samples	1646:1668	While ACP/TiO2 shows no antibacterial activity, ACP + ChOL/TiO2 samples exhibited three- to fourfold decreases in the number of Staphylococcus aureus and Pseudomonas aeruginosa, respectively, after 420 min.
34152124	1	40	dep	resistivity	249:259	arg1	coatings					388:395	potentially multifunctional composite coatings	350:395	potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate	350:539	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	10	41	theme	bacterial	1853:1861	arg1	wall					1868:1871	the bacterial cell wall	1849:1871	the bacterial cell wall	1849:1871	The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
34152124	6	42	with	coating	1267:1273	arg1	resistance					1295:1304	high corrosion resistance	1280:1304	high corrosion resistance	1280:1304	This deposition mechanism resulted in the formation of strongly bonded uniform stable coating with high corrosion resistance.
34152124	3	43	theme	hybrid	803:808	arg1	phases					820:825	hybrid composite phases	803:825	hybrid composite phases	803:825	The obtained coatings were around 300 ± 15 μm thick and consisted of two phases, namely, TiO2 and hybrid composite phases.
34152124	3	43	theme	hybrid	803:808	arg1	phases					778:783	two phases	774:783	two phases	774:783	The obtained coatings were around 300 ± 15 μm thick and consisted of two phases, namely, TiO2 and hybrid composite phases.
34152124	5	44	theme	TiO2	1175:1178	arg1	growth					1165:1170	simultaneous growth	1152:1170	simultaneous growth of TiO2	1152:1178	It was shown that at the very start of the deposition process, the formation of the ChOL/TiO2 layer takes place predominantly, which is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2.
34152124	4	45	theme	improved	867:874	arg1	stability					886:894	improved corrosion stability	867:894	improved corrosion stability	867:894	Both ACP/TiO2 and ACP + ChOL/TiO2 have improved corrosion stability, whereas the ACP + ChOL/TiO2 coating showed better corrosion stability.
34152124	6	46	theme	stable	1260:1265	arg1	coating					1267:1273	strongly bonded uniform stable coating	1236:1273	strongly bonded uniform stable coating with high corrosion resistance	1236:1304	This deposition mechanism resulted in the formation of strongly bonded uniform stable coating with high corrosion resistance.
34152124	5	47	with	ACP	1143:1145	arg1	growth					1165:1170	simultaneous growth	1152:1170	simultaneous growth of TiO2	1152:1178	It was shown that at the very start of the deposition process, the formation of the ChOL/TiO2 layer takes place predominantly, which is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2.
34152124	1	48	theme	novel	305:309	arg1	ACP					345:347	ACP	345:347	ACP	345:347	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	1	48	theme	novel	305:309	arg1	phosphate					334:342	novel nano-amorphous calcium phosphate	305:342	novel nano-amorphous calcium phosphate (ACP)	305:348	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	9	49	theme	ACP	1646:1648	arg1	samples					1662:1668	ACP + ChOL/TiO2 samples	1646:1668	ACP + ChOL/TiO2 samples	1646:1668	While ACP/TiO2 shows no antibacterial activity, ACP + ChOL/TiO2 samples exhibited three- to fourfold decreases in the number of Staphylococcus aureus and Pseudomonas aeruginosa, respectively, after 420 min.
34152124	9	50	theme	fourfold	1690:1697	arg1	decreases					1699:1707	three- to fourfold decreases	1680:1707	three- to fourfold decreases in the number of Staphylococcus aureus and Pseudomonas aeruginosa	1680:1773	While ACP/TiO2 shows no antibacterial activity, ACP + ChOL/TiO2 samples exhibited three- to fourfold decreases in the number of Staphylococcus aureus and Pseudomonas aeruginosa, respectively, after 420 min.
34152124	6	51	theme	bonded	1245:1250	arg1	coating					1267:1273	strongly bonded uniform stable coating	1236:1273	strongly bonded uniform stable coating with high corrosion resistance	1236:1304	This deposition mechanism resulted in the formation of strongly bonded uniform stable coating with high corrosion resistance.
34152124	2	52	dep	in	588:589	arg1	situ					591:594	situ	591:594	situ	591:594	The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL.
34152124	2	53	theme	electrodeposition	662:678	arg1	process					680:686	the anaphoretic electrodeposition process	646:686	the anaphoretic electrodeposition process of ACP and ChOL	646:702	The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL.
34152124	10	54	theme	membrane	1935:1942	arg1	permeability					1910:1921	the permeability	1906:1921	the permeability of the cell membrane	1906:1942	The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
34152124	4	55	theme	ChOL/TiO2	915:923	arg1	coating					925:931	the ACP + ChOL/TiO2 coating	905:931	the ACP + ChOL/TiO2 coating	905:931	Both ACP/TiO2 and ACP + ChOL/TiO2 have improved corrosion stability, whereas the ACP + ChOL/TiO2 coating showed better corrosion stability.
34152124	8	56	theme	apatite	1426:1432	arg1	formation					1434:1442	in-bone-like apatite formation	1413:1442	in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy	1413:1595	There is in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy.
34152124	5	57	theme	layer	1062:1066	arg1	formation					1035:1043	the formation	1031:1043	the formation of the ChOL/TiO2 layer	1031:1066	It was shown that at the very start of the deposition process, the formation of the ChOL/TiO2 layer takes place predominantly, which is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2.
34152124	2	58	theme	new	572:574	arg1	anodization					596:606	new single-step in situ anodization	572:606	new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL	572:702	The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL.
34152124	7	59	theme	simulated	1376:1384	arg1	SBF					1398:1400	SBF	1398:1400	SBF	1398:1400	In vitro bioactivity was investigated by immersion of the samples in simulated body fluid (SBF).
34152124	7	59	theme	simulated	1376:1384	arg1	fluid					1391:1395	simulated body fluid	1376:1395	simulated body fluid (SBF)	1376:1401	In vitro bioactivity was investigated by immersion of the samples in simulated body fluid (SBF).
34152124	7	60	theme	samples	1365:1371	arg1	immersion					1348:1356	immersion	1348:1356	immersion of the samples in simulated body fluid (SBF)	1348:1401	In vitro bioactivity was investigated by immersion of the samples in simulated body fluid (SBF).
34152124	6	61	theme	corrosion	1285:1293	arg1	resistance					1295:1304	high corrosion resistance	1280:1304	high corrosion resistance	1280:1304	This deposition mechanism resulted in the formation of strongly bonded uniform stable coating with high corrosion resistance.
34152124	4	62	contain	have	862:865	arg1	ACP					846:848	ACP	846:848	ACP	846:848	Both ACP/TiO2 and ACP + ChOL/TiO2 have improved corrosion stability, whereas the ACP + ChOL/TiO2 coating showed better corrosion stability.
34152124	4	62	contain	have	862:865	arg2	stability					886:894	improved corrosion stability	867:894	improved corrosion stability	867:894	Both ACP/TiO2 and ACP + ChOL/TiO2 have improved corrosion stability, whereas the ACP + ChOL/TiO2 coating showed better corrosion stability.
34152124	4	62	contain	have	862:865	arg1	ACP/TiO2					833:840	ACP/TiO2	833:840	ACP/TiO2	833:840	Both ACP/TiO2 and ACP + ChOL/TiO2 have improved corrosion stability, whereas the ACP + ChOL/TiO2 coating showed better corrosion stability.
34152124	4	63	theme	ACP	909:911	arg1	coating					925:931	the ACP + ChOL/TiO2 coating	905:931	the ACP + ChOL/TiO2 coating	905:931	Both ACP/TiO2 and ACP + ChOL/TiO2 have improved corrosion stability, whereas the ACP + ChOL/TiO2 coating showed better corrosion stability.
34152124	9	64	dep	fourfold	1690:1697	arg1	to					1687:1688	to	1687:1688	to	1687:1688	While ACP/TiO2 shows no antibacterial activity, ACP + ChOL/TiO2 samples exhibited three- to fourfold decreases in the number of Staphylococcus aureus and Pseudomonas aeruginosa, respectively, after 420 min.
34152124	1	65	theme	ACP/TiO2	475:482	arg1	ACP					484:486	ACP/TiO2 ACP	475:486	ACP/TiO2 ACP	475:486	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	10	66	theme	probable	1809:1816	arg1	mechanism					1818:1826	The probable mechanism	1805:1826	The probable mechanism	1805:1826	The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
34152124	10	66	theme	probable	1809:1816	arg1	ChOL					1839:1842	binding ChOL	1831:1842	binding ChOL with the bacterial cell wall	1831:1871	The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
34152124	9	67	theme	aureus	1741:1746	arg1	number					1716:1721	the number	1712:1721	the number of Staphylococcus aureus and Pseudomonas aeruginosa	1712:1773	While ACP/TiO2 shows no antibacterial activity, ACP + ChOL/TiO2 samples exhibited three- to fourfold decreases in the number of Staphylococcus aureus and Pseudomonas aeruginosa, respectively, after 420 min.
34152124	8	68	theme	ChOL/TiO2	1471:1479	arg1	surfaces					1481:1488	both ACP/TiO2 and ACP + ChOL/TiO2 surfaces	1447:1488	surfaces	1481:1488	There is in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy.
34152124	1	69	from	ACP	455:457	arg1	substrate					531:539	the titanium substrate	518:539	the titanium substrate	518:539	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	0	70	theme	Advanced	125:132	arg1	Resistance					144:153	Advanced Corrosion Resistance	125:153	Advanced Corrosion Resistance	125:153	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.
34152124	2	71	theme	in	588:589	arg1	anodization					596:606	new single-step in situ anodization	572:606	new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL	572:702	The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL.
34152124	0	72	from	Electrodeposition	22:38	arg1	Titanium					111:118	Titanium	111:118	Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties	111:196	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.
34152124	2	73	theme	ChOL	699:702	arg1	TiO2					637:640	TiO2	637:640	TiO2	637:640	The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL.
34152124	2	73	theme	ChOL	699:702	arg1	process					680:686	the anaphoretic electrodeposition process	646:686	the anaphoretic electrodeposition process of ACP and ChOL	646:702	The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL.
34152124	5	74	theme	ChOL/TiO2	1052:1060	arg1	layer					1062:1066	the ChOL/TiO2 layer	1048:1066	the ChOL/TiO2 layer	1048:1066	It was shown that at the very start of the deposition process, the formation of the ChOL/TiO2 layer takes place predominantly, which is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2.
34152124	4	75	theme	corrosion	947:955	arg1	stability					957:965	better corrosion stability	940:965	better corrosion stability	940:965	Both ACP/TiO2 and ACP + ChOL/TiO2 have improved corrosion stability, whereas the ACP + ChOL/TiO2 coating showed better corrosion stability.
34152124	2	76	theme	ACP	691:693	arg1	TiO2					637:640	TiO2	637:640	TiO2	637:640	The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL.
34152124	2	76	theme	ACP	691:693	arg1	process					680:686	the anaphoretic electrodeposition process	646:686	the anaphoretic electrodeposition process of ACP and ChOL	646:702	The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL.
34152124	1	77	theme	oligosaccharide	423:437	arg1	ChOL					448:451	ChOL	448:451	ChOL	448:451	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	1	77	theme	oligosaccharide	423:437	arg1	lactate					439:445	chitosan oligosaccharide lactate	414:445	chitosan oligosaccharide lactate (ChOL)	414:452	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	1	78	from	lactate	439:445	arg1	substrate					531:539	the titanium substrate	518:539	the titanium substrate	518:539	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	8	79	dep	transform	1565:1573	arg1	infrared					1575:1582	infrared	1575:1582	transform infrared spectroscopy	1565:1595	There is in-bone-like apatite formation on both ACP/TiO2 and ACP + ChOL/TiO2 surfaces upon immersion into SBF, which was proven by X-ray diffraction and Fourier transform infrared spectroscopy.
34152124	7	80	theme	In	1307:1308	arg1	bioactivity					1316:1326	In vitro bioactivity	1307:1326	In vitro bioactivity	1307:1326	In vitro bioactivity was investigated by immersion of the samples in simulated body fluid (SBF).
34152124	2	81	theme	single-step	576:586	arg1	anodization					596:606	new single-step in situ anodization	572:606	new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL	572:702	The coatings were obtained by new single-step in situ anodization of the substrate to generate TiO2 and the anaphoretic electrodeposition process of ACP and ChOL.
34152124	0	82	theme	Nano-Calcium	43:54	arg1	Coatings					99:106	Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings	43:106	Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings	43:106	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.
34152124	1	83	theme	phosphate	334:342	arg1	bioactivity					262:272	bioactivity	262:272	bioactivity	262:272	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	1	83	theme	phosphate	334:342	arg1	resistivity					249:259	corrosion resistivity	239:259	corrosion resistivity	239:259	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	1	83	theme	phosphate	334:342	arg1	activity					293:300	antibacterial activity	279:300	antibacterial activity of novel nano-amorphous calcium phosphate (ACP)	279:348	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	0	84	theme	Lactate	75:81	arg1	Coatings					99:106	Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings	43:106	Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings	43:106	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.
34152124	7	85	dep	In	1307:1308	arg1	vitro					1310:1314	vitro	1310:1314	vitro	1310:1314	In vitro bioactivity was investigated by immersion of the samples in simulated body fluid (SBF).
34152124	1	86	theme	titanium	522:529	arg1	substrate					531:539	the titanium substrate	518:539	the titanium substrate	518:539	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	0	87	theme	Coatings	99:106	arg1	Electrodeposition					22:38	Anodizing/Anaphoretic Electrodeposition	0:38	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.	0:197	Anodizing/Anaphoretic Electrodeposition of Nano-Calcium Phosphate/Chitosan Lactate Multifunctional Coatings on Titanium with Advanced Corrosion Resistance, Bioactivity, and Antibacterial Properties.
34152124	5	88	theme	ChOL	1133:1136	arg1	inclusion					1120:1128	the inclusion	1116:1128	the inclusion of ChOL into ACP with simultaneous growth of TiO2	1116:1178	It was shown that at the very start of the deposition process, the formation of the ChOL/TiO2 layer takes place predominantly, which is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2.
34152124	5	89	theme	process	1022:1028	arg1	start					998:1002	the very start	989:1002	the very start of the deposition process	989:1028	It was shown that at the very start of the deposition process, the formation of the ChOL/TiO2 layer takes place predominantly, which is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2.
34152124	10	90	with	ChOL	1839:1842	arg1	wall					1868:1871	the bacterial cell wall	1849:1871	the bacterial cell wall	1849:1871	The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
34152124	3	91	theme	obtained	709:716	arg1	coatings					718:725	The obtained coatings	705:725	The obtained coatings	705:725	The obtained coatings were around 300 ± 15 μm thick and consisted of two phases, namely, TiO2 and hybrid composite phases.
34152124	1	92	theme	composite	378:386	arg1	coatings					388:395	potentially multifunctional composite coatings	350:395	potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate	350:539	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	5	93	dep	takes	1068:1072	arg1	followed					1104:1111	followed	1104:1111	is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2	1101:1178	It was shown that at the very start of the deposition process, the formation of the ChOL/TiO2 layer takes place predominantly, which is followed by the inclusion of ChOL into ACP with simultaneous growth of TiO2.
34152124	10	94	theme	cell	1863:1866	arg1	wall					1868:1871	the bacterial cell wall	1849:1871	the bacterial cell wall	1849:1871	The probable mechanism is binding ChOL with the bacterial cell wall, inhibiting its growth, altering the permeability of the cell membrane, and leading to bacterial death.
34152124	1	95	from	ChOL/TiO2	490:498	arg1	substrate					531:539	the titanium substrate	518:539	the titanium substrate	518:539	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
34152124	1	96	theme	antibacterial	279:291	arg1	activity					293:300	antibacterial activity	279:300	antibacterial activity of novel nano-amorphous calcium phosphate (ACP)	279:348	The aim of this work was to investigate corrosion resistivity, bioactivity, and antibacterial activity of novel nano-amorphous calcium phosphate (ACP) potentially multifunctional composite coatings with and without chitosan oligosaccharide lactate (ChOL), ACP + ChOL/TiO2 and ACP/TiO2 ACP + ChOL/TiO2, respectively, on the titanium substrate.
32058599	4	0	from	variations	906:915	arg1	treatments					925:934	both treatments	920:934	both treatments	920:934	The measured δ18 Ocell along the ring was responsive to RH variations in both treatments.
32058599	2	1	theme	oxygen	550:555	arg1	composition					566:576	the oxygen isotopic composition	546:576	the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH	546:716	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	5	2	theme	measured	985:992	arg1	Ocell					998:1002	measured δ18 Ocell	985:1002	measured δ18 Ocell	985:1002	However, estimated δ18 Ocell did not agree with measured δ18 Ocell when the proportion of exchangeable oxygen during cellulose synthesis (Pex ) was kept constant.
32058599	1	3	theme	resolution	136:145	arg1	measurements					147:158	High temporal resolution measurements	122:158	High temporal resolution measurements of wood anatomy	122:174	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	7	4	theme	water	1405:1409	arg1	cellulose					1360:1368	late-season cellulose	1348:1368	late-season cellulose	1348:1368	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	7	4	theme	water	1405:1409	arg1	recorder					1382:1389	a better recorder	1373:1389	a better recorder of the source water	1373:1409	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	7	5	theme	RH	1339:1340	arg1	recorder					1327:1334	a better recorder	1318:1334	a better recorder of RH	1318:1340	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	7	5	theme	RH	1339:1340	arg1	cellulose					1305:1313	earlier season cellulose	1290:1313	earlier season cellulose	1290:1313	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	2	6	from	features	423:430	arg1	Pseudotsuga					455:465	Pseudotsuga	455:465	Pseudotsuga	455:465	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	6	from	features	423:430	arg1	ponderosa					441:449	ponderosa	441:449	ponderosa	441:449	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	7	7	theme	better	1375:1380	arg1	cellulose					1360:1368	late-season cellulose	1348:1368	late-season cellulose	1348:1368	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	7	7	theme	better	1375:1380	arg1	recorder					1382:1389	a better recorder	1373:1389	a better recorder of the source water	1373:1409	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	3	8	theme	significant	733:743	arg1	decrease					745:752	a significant decrease	731:752	a significant decrease in LA	731:758	We observed a significant decrease in LA and a small increase in CWT within the experimental growing season in both treatments.
32058599	0	9	from	Reduction	0:8	arg1	area					19:22	lumen area	13:22	lumen area	13:22	Reduction in lumen area is associated with the δ18 O exchange between sugars and source water during cellulose synthesis.
32058599	1	10	from	measurements	147:158	arg1	tree-rings					208:217	tree-rings	208:217	tree-rings	208:217	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	3	11	theme	small	766:770	arg1	increase					772:779	a small increase	764:779	a small increase in CWT	764:786	We observed a significant decrease in LA and a small increase in CWT within the experimental growing season in both treatments.
32058599	7	12	theme	earlier	1290:1296	arg1	recorder					1327:1334	a better recorder	1318:1334	a better recorder of RH	1318:1340	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	7	12	theme	earlier	1290:1296	arg1	cellulose					1305:1313	earlier season cellulose	1290:1313	earlier season cellulose	1290:1313	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	7	13	theme	source	1398:1403	arg1	water					1405:1409	the source water	1394:1409	the source water	1394:1409	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	4	14	theme	measured	851:858	arg1	responsive					889:898	responsive	889:898	responsive	889:898	The measured δ18 Ocell along the ring was responsive to RH variations in both treatments.
32058599	4	14	theme	measured	851:858	arg1	Ocell					864:868	The measured δ18 Ocell	847:868	The measured δ18 Ocell along the ring	847:883	The measured δ18 Ocell along the ring was responsive to RH variations in both treatments.
32058599	2	15	theme	α-cellulose	581:591	arg1	composition					566:576	the oxygen isotopic composition	546:576	the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH	546:716	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	3	16	from	increase	772:779	arg1	LA					757:758	LA	757:758	LA	757:758	We observed a significant decrease in LA and a small increase in CWT within the experimental growing season in both treatments.
32058599	3	16	from	increase	772:779	arg1	CWT					784:786	CWT	784:786	CWT	784:786	We observed a significant decrease in LA and a small increase in CWT within the experimental growing season in both treatments.
32058599	2	17	theme	high-low	670:677	arg1	RH					679:680	high-low RH	670:680	high-low RH	670:680	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	0	18	theme	source	81:86	arg1	water					88:92	source water	81:92	source water	81:92	Reduction in lumen area is associated with the δ18 O exchange between sugars and source water during cellulose synthesis.
32058599	7	19	theme	season	1298:1303	arg1	recorder					1327:1334	a better recorder	1318:1334	a better recorder of RH	1318:1340	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	7	19	theme	season	1298:1303	arg1	cellulose					1305:1313	earlier season cellulose	1290:1313	earlier season cellulose	1290:1313	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	5	20	theme	δ18	994:996	arg1	Ocell					998:1002	measured δ18 Ocell	985:1002	measured δ18 Ocell	985:1002	However, estimated δ18 Ocell did not agree with measured δ18 Ocell when the proportion of exchangeable oxygen during cellulose synthesis (Pex ) was kept constant.
32058599	2	21	theme	relative	619:626	arg1	RH					638:639	RH	638:639	RH	638:639	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	21	theme	relative	619:626	arg1	humidity					628:635	relative humidity	619:635	relative humidity (RH)	619:640	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	4	22	theme	RH	903:904	arg1	variations					906:915	RH variations	903:915	RH variations in both treatments	903:934	The measured δ18 Ocell along the ring was responsive to RH variations in both treatments.
32058599	1	23	theme	wood	163:166	arg1	anatomy					168:174	wood anatomy	163:174	wood anatomy	163:174	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	2	24	theme	features	423:430	arg1	response					395:402	the response	391:402	the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA),	391:533	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	25	from	ponderosa	441:449	arg1	response					395:402	the response	391:402	the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA),	391:533	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	5	26	theme	cellulose	1054:1062	arg1	Pex					1075:1077	Pex	1075:1077	Pex	1075:1077	However, estimated δ18 Ocell did not agree with measured δ18 Ocell when the proportion of exchangeable oxygen during cellulose synthesis (Pex ) was kept constant.
32058599	5	26	theme	cellulose	1054:1062	arg1	synthesis					1064:1072	cellulose synthesis	1054:1072	cellulose synthesis (Pex )	1054:1079	However, estimated δ18 Ocell did not agree with measured δ18 Ocell when the proportion of exchangeable oxygen during cellulose synthesis (Pex ) was kept constant.
32058599	3	27	from	decrease	745:752	arg1	LA					757:758	LA	757:758	LA	757:758	We observed a significant decrease in LA and a small increase in CWT within the experimental growing season in both treatments.
32058599	3	27	from	decrease	745:752	arg1	CWT					784:786	CWT	784:786	CWT	784:786	We observed a significant decrease in LA and a small increase in CWT within the experimental growing season in both treatments.
32058599	1	28	theme	anatomy	168:174	arg1	composition					193:203	the isotopic composition	180:203	the isotopic composition in tree-rings	180:217	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	1	28	theme	anatomy	168:174	arg1	measurements					147:158	High temporal resolution measurements	122:158	High temporal resolution measurements of wood anatomy	122:174	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	2	29	theme	anatomical	412:421	arg1	thickness					498:506	cell-wall thickness	488:506	cell-wall thickness (CWT)	488:512	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	29	theme	anatomical	412:421	arg1	features					423:430	wood anatomical features	407:430	wood anatomical features	407:430	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	29	theme	anatomical	412:421	arg1	area					524:527	lumen area	518:527	lumen area (LA)	518:532	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	30	theme	isotopic	557:564	arg1	composition					566:576	the oxygen isotopic composition	546:576	the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH	546:716	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	7	31	theme	different	1258:1266	arg1	signals					1281:1287	different hydroclimate signals	1258:1287	different hydroclimate signals	1258:1287	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	5	32	theme	δ18	956:958	arg1	Ocell					960:964	estimated δ18 Ocell	946:964	estimated δ18 Ocell	946:964	However, estimated δ18 Ocell did not agree with measured δ18 Ocell when the proportion of exchangeable oxygen during cellulose synthesis (Pex ) was kept constant.
32058599	2	33	theme	wood	407:410	arg1	thickness					498:506	cell-wall thickness	488:506	cell-wall thickness (CWT)	488:512	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	33	theme	wood	407:410	arg1	features					423:430	wood anatomical features	407:430	wood anatomical features	407:430	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	33	theme	wood	407:410	arg1	area					524:527	lumen area	518:527	lumen area (LA)	518:532	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	1	34	theme	climate	271:277	arg1	variability					279:289	climate variability	271:289	climate variability	271:289	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	0	35	theme	cellulose	101:109	arg1	synthesis					111:119	cellulose synthesis	101:119	cellulose synthesis	101:119	Reduction in lumen area is associated with the δ18 O exchange between sugars and source water during cellulose synthesis.
32058599	7	36	theme	sampling	1236:1243	arg1	strategy					1245:1252	a targeted sampling strategy	1225:1252	a targeted sampling strategy for different hydroclimate signals	1225:1287	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	2	37	theme	second	690:695	arg1	form					701:704	the second one form	686:704	the second one form	686:704	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	0	38	theme	lumen	13:17	arg1	area					19:22	lumen area	13:22	lumen area	13:22	Reduction in lumen area is associated with the δ18 O exchange between sugars and source water during cellulose synthesis.
32058599	1	39	theme	variability	279:289	arg1	interpretation					253:266	our interpretation	249:266	our interpretation of climate variability	249:289	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	2	40	theme	lumen	518:522	arg1	LA					530:531	LA	530:531	LA	530:531	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	40	theme	lumen	518:522	arg1	area					524:527	lumen area	518:527	lumen area (LA)	518:532	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	5	41	theme	estimated	946:954	arg1	Ocell					960:964	estimated δ18 Ocell	946:964	estimated δ18 Ocell	946:964	However, estimated δ18 Ocell did not agree with measured δ18 Ocell when the proportion of exchangeable oxygen during cellulose synthesis (Pex ) was kept constant.
32058599	3	42	theme	growing	812:818	arg1	season					820:825	the experimental growing season	795:825	the experimental growing season in both treatments	795:844	We observed a significant decrease in LA and a small increase in CWT within the experimental growing season in both treatments.
32058599	1	43	theme	isotopic	184:191	arg1	composition					193:203	the isotopic composition	180:203	the isotopic composition in tree-rings	180:217	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	3	44	theme	experimental	799:810	arg1	season					820:825	the experimental growing season	795:825	the experimental growing season in both treatments	795:844	We observed a significant decrease in LA and a small increase in CWT within the experimental growing season in both treatments.
32058599	2	45	from	Pseudotsuga	455:465	arg1	response					395:402	the response	391:402	the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA),	391:533	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	7	46	theme	varying	1179:1185	arg1	Pex					1187:1189	this varying Pex	1174:1189	this varying Pex within an annual ring	1174:1211	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	7	47	theme	better	1320:1325	arg1	recorder					1327:1334	a better recorder	1318:1334	a better recorder of RH	1318:1340	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	7	47	theme	better	1320:1325	arg1	cellulose					1305:1313	earlier season cellulose	1290:1313	earlier season cellulose	1290:1313	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	3	48	from	season	820:825	arg1	treatments					835:844	both treatments	830:844	both treatments	830:844	We observed a significant decrease in LA and a small increase in CWT within the experimental growing season in both treatments.
32058599	1	49	from	composition	193:203	arg1	tree-rings					208:217	tree-rings	208:217	tree-rings	208:217	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	2	50	theme	cell-wall	488:496	arg1	thickness					498:506	cell-wall thickness	488:506	cell-wall thickness (CWT)	488:512	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	50	theme	cell-wall	488:496	arg1	CWT					509:511	CWT	509:511	CWT	509:511	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	4	51	theme	δ18	860:862	arg1	responsive					889:898	responsive	889:898	responsive	889:898	The measured δ18 Ocell along the ring was responsive to RH variations in both treatments.
32058599	4	51	theme	δ18	860:862	arg1	Ocell					864:868	The measured δ18 Ocell	847:868	The measured δ18 Ocell along the ring	847:883	The measured δ18 Ocell along the ring was responsive to RH variations in both treatments.
32058599	1	52	contain	have	219:222	arg1	composition					193:203	the isotopic composition	180:203	the isotopic composition in tree-rings	180:217	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	1	52	contain	have	219:222	arg2	potential					228:236	the potential to enhance our interpretation of climate variability	224:289	the potential to enhance our interpretation of climate variability	224:289	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	1	52	contain	have	219:222	arg1	measurements					147:158	High temporal resolution measurements	122:158	High temporal resolution measurements of wood anatomy	122:174	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	1	53	theme	growing	332:338	arg1	season					340:345	the growing season	328:345	the growing season	328:345	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	5	54	theme	exchangeable	1027:1038	arg1	oxygen					1040:1045	exchangeable oxygen	1027:1045	exchangeable oxygen	1027:1045	However, estimated δ18 Ocell did not agree with measured δ18 Ocell when the proportion of exchangeable oxygen during cellulose synthesis (Pex ) was kept constant.
32058599	2	55	dep	Pseudotsuga	455:465	arg1	menziesii					467:475	Pseudotsuga menziesii	455:475	Pseudotsuga menziesii	455:475	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	5	56	theme	oxygen	1040:1045	arg1	proportion					1013:1022	the proportion	1009:1022	the proportion of exchangeable oxygen during cellulose synthesis (Pex )	1009:1079	However, estimated δ18 Ocell did not agree with measured δ18 Ocell when the proportion of exchangeable oxygen during cellulose synthesis (Pex ) was kept constant.
32058599	5	56	theme	oxygen	1040:1045	arg1	constant					1090:1097	constant	1090:1097	constant	1090:1097	However, estimated δ18 Ocell did not agree with measured δ18 Ocell when the proportion of exchangeable oxygen during cellulose synthesis (Pex ) was kept constant.
32058599	7	57	theme	hydroclimate	1268:1279	arg1	signals					1281:1287	different hydroclimate signals	1258:1287	different hydroclimate signals	1258:1287	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	2	58	dep	RH	679:680	arg1	RH					715:716	low-high RH	706:716	low-high RH	706:716	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	59	from	shifts	609:614	arg1	RH					638:639	RH	638:639	RH	638:639	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	59	from	shifts	609:614	arg1	humidity					628:635	relative humidity	619:635	relative humidity (RH)	619:640	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	59	from	shifts	609:614	arg1	treatments					649:658	two treatments	645:658	two treatments	645:658	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	59	from	shifts	609:614	arg1	one					661:663	one	661:663	one	661:663	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	60	theme	low-high	706:713	arg1	RH					715:716	low-high RH	706:716	low-high RH	706:716	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	0	61	theme	O	51:51	arg1	exchange					53:60	the δ18 O exchange	43:60	the δ18 O exchange between sugars and source water during cellulose synthesis	43:119	Reduction in lumen area is associated with the δ18 O exchange between sugars and source water during cellulose synthesis.
32058599	7	62	theme	late-season	1348:1358	arg1	cellulose					1360:1368	late-season cellulose	1348:1368	late-season cellulose	1348:1368	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	7	62	theme	late-season	1348:1358	arg1	recorder					1382:1389	a better recorder	1373:1389	a better recorder of the source water	1373:1409	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	1	63	theme	High	122:125	arg1	measurements					147:158	High temporal resolution measurements	122:158	High temporal resolution measurements of wood anatomy	122:174	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	5	64	with	agree	974:978	arg1	Ocell					998:1002	measured δ18 Ocell	985:1002	measured δ18 Ocell	985:1002	However, estimated δ18 Ocell did not agree with measured δ18 Ocell when the proportion of exchangeable oxygen during cellulose synthesis (Pex ) was kept constant.
32058599	0	65	theme	δ18	47:49	arg1	exchange					53:60	the δ18 O exchange	43:60	the δ18 O exchange between sugars and source water during cellulose synthesis	43:119	Reduction in lumen area is associated with the δ18 O exchange between sugars and source water during cellulose synthesis.
32058599	1	66	theme	variation	311:319	arg1	sources					300:306	the sources	296:306	the sources of variation within the growing season	296:345	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	7	67	theme	annual	1201:1206	arg1	ring					1208:1211	an annual ring	1198:1211	an annual ring	1198:1211	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
32058599	2	68	from	response	395:402	arg1	Pseudotsuga					455:465	Pseudotsuga	455:465	Pseudotsuga	455:465	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	2	68	from	response	395:402	arg1	ponderosa					441:449	ponderosa	441:449	ponderosa	441:449	Here we test the response of wood anatomical features in Pinus ponderosa and Pseudotsuga menziesii, including cell-wall thickness (CWT) and lumen area (LA), along with the oxygen isotopic composition of α-cellulose (δ18 Ocell ) to shifts in relative humidity (RH) in two treatments, one from high-low RH and the second one form low-high RH.
32058599	1	69	theme	temporal	127:134	arg1	measurements					147:158	High temporal resolution measurements	122:158	High temporal resolution measurements of wood anatomy	122:174	High temporal resolution measurements of wood anatomy and the isotopic composition in tree-rings have the potential to enhance our interpretation of climate variability, but the sources of variation within the growing season are still not well understood.
32058599	7	70	theme	targeted	1227:1234	arg1	strategy					1245:1252	a targeted sampling strategy	1225:1252	a targeted sampling strategy for different hydroclimate signals	1225:1287	Based on this varying Pex within an annual ring, we propose a targeted sampling strategy for different hydroclimate signals: earlier season cellulose is a better recorder of RH while late-season cellulose is a better recorder of the source water.
34200763	0	0	theme	5,10,15,20-Tetrakis	116:134	arg1	porphyrin					152:160	5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin	116:160	5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin	116:160	Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin.
34200763	1	1	theme	strategies	200:209	arg1	development					167:177	The development	163:177	The development of new antimicrobial strategies that act more efficiently than traditional antibiotics	163:264	The development of new antimicrobial strategies that act more efficiently than traditional antibiotics is becoming a necessity to combat multidrug-resistant pathogens.
34200763	1	2	theme	multidrug-resistant	300:318	arg1	pathogens					320:328	multidrug-resistant pathogens	300:328	multidrug-resistant pathogens	300:328	The development of new antimicrobial strategies that act more efficiently than traditional antibiotics is becoming a necessity to combat multidrug-resistant pathogens.
34200763	6	3	theme	±	1331:1331	arg1	albicans					1258:1265	C. albicans	1255:1265	C. albicans (59 ± 0.21%)	1255:1278	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	6	3	theme	±	1331:1331	arg1	%					1337:1337	74.2 ± 1.26%	1326:1337	74.2 ± 1.26%	1326:1337	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	6	4	theme	photodynamic	1127:1138	arg1	experiments					1155:1165	the antimicrobial photodynamic therapy (aPDT) experiments	1109:1165	the antimicrobial photodynamic therapy (aPDT) experiments	1109:1165	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	7	5	theme	microbial	1458:1466	arg1	growth					1468:1473	microbial growth	1458:1473	microbial growth	1458:1473	Utilization of higher doses (70 mW) for longer periods achieved more eradication of microbial growth.
34200763	0	6	theme	m-Hydroxyphenyl	136:150	arg1	porphyrin					152:160	5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin	116:160	5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin	116:160	Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin.
34200763	4	7	theme	positive	871:878	arg1	charge					880:885	an overall positive charge	860:885	an overall positive charge	860:885	The results indicate that the prepared nanocomposite incorporates mTHPP inside, and that the composite acquired an overall positive charge.
34200763	6	8	with	nanocomposite	1237:1249	arg1	illumination					1345:1356	illumination	1345:1356	illumination of only 15 min	1345:1371	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	7	9	theme	doses	1396:1400	arg1	Utilization					1374:1384	Utilization	1374:1384	Utilization of higher doses (70 mW) for longer periods	1374:1427	Utilization of higher doses (70 mW) for longer periods achieved more eradication of microbial growth.
34200763	4	10	theme	overall	863:869	arg1	charge					880:885	an overall positive charge	860:885	an overall positive charge	860:885	The results indicate that the prepared nanocomposite incorporates mTHPP inside, and that the composite acquired an overall positive charge.
34200763	4	11	theme	mTHPP	814:818	arg1	inside					820:825	mTHPP inside	814:825	mTHPP inside	814:825	The results indicate that the prepared nanocomposite incorporates mTHPP inside, and that the composite acquired an overall positive charge.
34200763	2	12	theme	Candida	590:596	arg1	albicans					598:605	Candida albicans	590:605	Candida albicans	590:605	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	6	13	theme	therapy	1140:1146	arg1	experiments					1155:1165	the antimicrobial photodynamic therapy (aPDT) experiments	1109:1165	the antimicrobial photodynamic therapy (aPDT) experiments	1109:1165	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	3	14	theme	Surface	608:614	arg1	loading					616:622	Surface loading	608:622	Surface loading of the ethylcelllose/chitosan composite with mTHPP	608:673	Surface loading of the ethylcelllose/chitosan composite with mTHPP was carried out and the resulting nanocomposite was fully characterized.
34200763	2	15	theme	EC	470:471	arg1	nanocomposite					489:501	an ethylcellulose (EC)/chitosan (Chs) nanocomposite	451:501	an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug	451:527	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	6	16	dep	P.	1281:1282	arg1	aeruginosa					1284:1293	P. aeruginosa (71.7 ± 1.72%)	1281:1308	P. aeruginosa (71.7 ± 1.72%)	1281:1308	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	6	17	theme	antimicrobial	1113:1125	arg1	experiments					1155:1165	the antimicrobial photodynamic therapy (aPDT) experiments	1109:1165	the antimicrobial photodynamic therapy (aPDT) experiments	1109:1165	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	2	18	theme	eradicating	506:516	arg1	multi-drug					518:527	eradicating multi-drug	506:527	eradicating multi-drug	506:527	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	7	19	theme	higher	1389:1394	arg1	doses					1396:1400	higher doses	1389:1400	higher doses (70 mW)	1389:1408	Utilization of higher doses (70 mW) for longer periods achieved more eradication of microbial growth.
34200763	7	19	theme	higher	1389:1394	arg1	mW					1406:1407	70 mW	1403:1407	70 mW	1403:1407	Utilization of higher doses (70 mW) for longer periods achieved more eradication of microbial growth.
34200763	6	20	theme	±	1271:1271	arg1	%					1277:1277	59 ± 0.21%	1268:1277	59 ± 0.21%	1268:1277	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	6	20	theme	±	1271:1271	arg1	albicans					1258:1265	C. albicans	1255:1265	C. albicans (59 ± 0.21%)	1255:1278	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	2	21	theme	ethylcellulose	454:467	arg1	nanocomposite					489:501	an ethylcellulose (EC)/chitosan (Chs) nanocomposite	451:501	an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug	451:527	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	2	22	theme	5,10,15,20-tetrakis	385:403	arg1	porphyrin					421:429	laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin	362:429	laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans	362:605	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	2	22	theme	5,10,15,20-tetrakis	385:403	arg1	mTHPP					432:436	mTHPP	432:436	mTHPP	432:436	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	7	23	theme	growth	1468:1473	arg1	eradication					1443:1453	more eradication	1438:1453	more eradication of microbial growth	1438:1473	Utilization of higher doses (70 mW) for longer periods achieved more eradication of microbial growth.
34200763	0	24	theme	Laser-Induced	29:41	arg1	Therapy					56:62	Antimicrobial Laser-Induced Photodynamic Therapy	15:62	Antimicrobial Laser-Induced Photodynamic Therapy	15:62	Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin.
34200763	2	25	theme	laser-light-irradiated	362:383	arg1	porphyrin					421:429	laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin	362:429	laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans	362:605	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	2	25	theme	laser-light-irradiated	362:383	arg1	mTHPP					432:436	mTHPP	432:436	mTHPP	432:436	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	2	26	theme	Chs	484:486	arg1	nanocomposite					489:501	an ethylcellulose (EC)/chitosan (Chs) nanocomposite	451:501	an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug	451:527	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	0	27	theme	Antimicrobial	15:27	arg1	Therapy					56:62	Antimicrobial Laser-Induced Photodynamic Therapy	15:62	Antimicrobial Laser-Induced Photodynamic Therapy	15:62	Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin.
34200763	6	28	theme	laser	991:995	arg1	wavelengths					997:1007	Different laser wavelengths	981:1007	Different laser wavelengths (458; 476; 488; 515; 635 nm)	981:1036	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	6	28	theme	laser	991:995	arg1	nm					1034:1035	458; 476; 488; 515; 635 nm	1010:1035	458; 476; 488; 515; 635 nm	1010:1035	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	3	29	theme	composite	654:662	arg1	loading					616:622	Surface loading	608:622	Surface loading of the ethylcelllose/chitosan composite with mTHPP	608:673	Surface loading of the ethylcelllose/chitosan composite with mTHPP was carried out and the resulting nanocomposite was fully characterized.
34200763	5	30	theme	photo-	951:956	arg1	stability					970:978	the photo- and thermal stability	947:978	the photo- and thermal stability	947:978	The incorporation of mTHPP into the nanocomposite enhanced the photo- and thermal stability.
34200763	0	31	theme	Therapy	56:62	arg1	Development					0:10	Development	0:10	Development of Antimicrobial Laser-Induced Photodynamic Therapy	0:62	Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin.
34200763	6	32	theme	Different	981:989	arg1	wavelengths					997:1007	Different laser wavelengths	981:1007	Different laser wavelengths (458; 476; 488; 515; 635 nm)	981:1036	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	6	32	theme	Different	981:989	arg1	nm					1034:1035	458; 476; 488; 515; 635 nm	1010:1035	458; 476; 488; 515; 635 nm	1010:1035	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	2	33	theme	/chitosan	473:481	arg1	nanocomposite					489:501	an ethylcellulose (EC)/chitosan (Chs) nanocomposite	451:501	an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug	451:527	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	0	34	theme	Photodynamic	43:54	arg1	Therapy					56:62	Antimicrobial Laser-Induced Photodynamic Therapy	15:62	Antimicrobial Laser-Induced Photodynamic Therapy	15:62	Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin.
34200763	3	35	with	loading	616:622	arg1	mTHPP					669:673	mTHPP	669:673	mTHPP	669:673	Surface loading of the ethylcelllose/chitosan composite with mTHPP was carried out and the resulting nanocomposite was fully characterized.
34200763	6	36	theme	min	1369:1371	arg1	illumination					1345:1356	illumination	1345:1356	illumination of only 15 min	1345:1371	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	5	37	theme	thermal	962:968	arg1	stability					970:978	the photo- and thermal stability	947:978	the photo- and thermal stability	947:978	The incorporation of mTHPP into the nanocomposite enhanced the photo- and thermal stability.
34200763	6	38	theme	aPDT	1149:1152	arg1	experiments					1155:1165	the antimicrobial photodynamic therapy (aPDT) experiments	1109:1165	the antimicrobial photodynamic therapy (aPDT) experiments	1109:1165	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	5	39	theme	mTHPP	909:913	arg1	incorporation					892:904	The incorporation	888:904	The incorporation of mTHPP into the nanocomposite	888:936	The incorporation of mTHPP into the nanocomposite enhanced the photo- and thermal stability.
34200763	6	40	theme	±	1301:1301	arg1	P.					1281:1282	P.	1281:1282	P.	1281:1282	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	6	40	theme	±	1301:1301	arg1	%					1307:1307	71.7 ± 1.72%	1296:1307	71.7 ± 1.72%	1296:1307	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	6	41	theme	best	1177:1180	arg1	inhibition					1182:1191	the best inhibition	1173:1191	the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min	1173:1371	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	2	42	theme	porphyrin	421:429	arg1	efficacy					350:357	the efficacy	346:357	the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans	346:605	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	7	43	theme	more	1438:1441	arg1	eradication					1443:1453	more eradication	1438:1453	more eradication of microbial growth	1438:1473	Utilization of higher doses (70 mW) for longer periods achieved more eradication of microbial growth.
34200763	4	44	theme	prepared	778:785	arg1	nanocomposite					787:799	the prepared nanocomposite	774:799	the prepared nanocomposite	774:799	The results indicate that the prepared nanocomposite incorporates mTHPP inside, and that the composite acquired an overall positive charge.
34200763	3	45	theme	ethylcelllose/chitosan	631:652	arg1	composite					654:662	the ethylcelllose/chitosan composite	627:662	the ethylcelllose/chitosan composite	627:662	Surface loading of the ethylcelllose/chitosan composite with mTHPP was carried out and the resulting nanocomposite was fully characterized.
34200763	7	46	theme	longer	1414:1419	arg1	periods					1421:1427	longer periods	1414:1427	longer periods	1414:1427	Utilization of higher doses (70 mW) for longer periods achieved more eradication of microbial growth.
34200763	6	47	theme	EC/Chs	1230:1235	arg1	nanocomposite					1237:1249	the mTHPP EC/Chs nanocomposite	1220:1249	the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min	1220:1371	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	2	48	theme	m-hydroxyphenyl	405:419	arg1	porphyrin					421:429	laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin	362:429	laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans	362:605	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	2	48	theme	m-hydroxyphenyl	405:419	arg1	mTHPP					432:436	mTHPP	432:436	mTHPP	432:436	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	6	49	theme	mTHPP	1224:1228	arg1	nanocomposite					1237:1249	the mTHPP EC/Chs nanocomposite	1220:1249	the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min	1220:1371	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	1	50	theme	traditional	242:252	arg1	antibiotics					254:264	traditional antibiotics	242:264	traditional antibiotics	242:264	The development of new antimicrobial strategies that act more efficiently than traditional antibiotics is becoming a necessity to combat multidrug-resistant pathogens.
34200763	1	51	theme	new	182:184	arg1	strategies					200:209	new antimicrobial strategies	182:209	new antimicrobial strategies that act more efficiently than traditional antibiotics	182:264	The development of new antimicrobial strategies that act more efficiently than traditional antibiotics is becoming a necessity to combat multidrug-resistant pathogens.
34200763	6	52	theme	exposure	1061:1068	arg1	times					1070:1074	exposure times	1061:1074	exposure times (15-45 min)	1061:1086	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	6	52	theme	exposure	1061:1068	arg1	min					1083:1085	15-45 min	1077:1085	15-45 min	1077:1085	Different laser wavelengths (458; 476; 488; 515; 635 nm), powers (5-70 mW), and exposure times (15-45 min) were investigated in the antimicrobial photodynamic therapy (aPDT) experiments, with the best inhibition observed using 635 nm with the mTHPP EC/Chs nanocomposite for C. albicans (59 ± 0.21%), P. aeruginosa (71.7 ± 1.72%), and S. aureus (74.2 ± 1.26%) with illumination of only 15 min.
34200763	2	53	from	nanocomposite	489:501	arg1	multi-drug					518:527	eradicating multi-drug	506:527	eradicating multi-drug	506:527	Here we report the efficacy of laser-light-irradiated 5,10,15,20-tetrakis(m-hydroxyphenyl)porphyrin (mTHPP) loaded onto an ethylcellulose (EC)/chitosan (Chs) nanocomposite in eradicating multi-drug resistant Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans.
34200763	3	54	theme	resulting	699:707	arg1	nanocomposite					709:721	the resulting nanocomposite	695:721	the resulting nanocomposite	695:721	Surface loading of the ethylcelllose/chitosan composite with mTHPP was carried out and the resulting nanocomposite was fully characterized.
34200763	1	55	theme	antimicrobial	186:198	arg1	strategies					200:209	new antimicrobial strategies	182:209	new antimicrobial strategies that act more efficiently than traditional antibiotics	182:264	The development of new antimicrobial strategies that act more efficiently than traditional antibiotics is becoming a necessity to combat multidrug-resistant pathogens.
34119424	7	0	theme	antibody	1103:1110	arg1	production					1112:1121	IgG antibody production	1099:1121	IgG antibody production	1099:1121	Here, we constructed a recombinant expression system for IgNAR using Chinese hamster ovary (CHO) cells, widely used as hosts for IgG antibody production.
34119424	5	1	theme	sites	887:891	arg1	weight					815:820	a molecular weight	803:820	a molecular weight of approximately 147 kDa as a dimer and multiple N-glycosylation sites	803:891	However, no recombinant expression system for IgNAR, which has a molecular weight of approximately 147 kDa as a dimer and multiple N-glycosylation sites, has yet been constructed.
34119424	8	2	theme	antigen-binding	1233:1247	arg1	ability					1249:1255	antigen-binding ability	1233:1255	antigen-binding ability	1233:1255	Using this system, IgNAR was successfully expressed and purified as a human IgG Fc fusion protein and showed antigen-binding ability.
34119424	11	3	theme	expression	1538:1547	arg1	system					1549:1554	This expression system	1533:1554	This expression system	1533:1554	This expression system will allow us to analyze the structure, physicochemical properties, and biological functions of IgNAR.
34119424	2	4	theme	immune	344:349	arg1	system					351:356	their adaptive immune system	329:356	their adaptive immune system called immunoglobulin new antigen receptor (IgNARs)	329:408	During their evolution, cartilaginous fishes individually have acquired their adaptive immune system called immunoglobulin new antigen receptor (IgNARs).
34119424	4	5	from	antibodies	660:669	arg1	applications					674:685	applications	674:685	applications different from those of conventional IgG antibodies	674:737	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	1	6	theme	similar	228:234	arg1	immunoglobulins					212:226	immunoglobulins	212:226	immunoglobulins similar to those in mammals	212:254	Cartilaginous fishes such as sharks have adaptive immune systems based on immunoglobulins similar to those in mammals.
34119424	8	7	theme	IgG	1200:1202	arg1	protein					1214:1220	a human IgG Fc fusion protein	1192:1220	a human IgG Fc fusion protein	1192:1220	Using this system, IgNAR was successfully expressed and purified as a human IgG Fc fusion protein and showed antigen-binding ability.
34119424	8	7	theme	IgG	1200:1202	arg1	IgNAR					1143:1147	IgNAR	1143:1147	IgNAR	1143:1147	Using this system, IgNAR was successfully expressed and purified as a human IgG Fc fusion protein and showed antigen-binding ability.
34119424	5	8	theme	147 kDa	839:845	arg1	sites					887:891	approximately 147 kDa as a dimer and multiple N-glycosylation sites	825:891	approximately 147 kDa as a dimer and multiple N-glycosylation sites	825:891	However, no recombinant expression system for IgNAR, which has a molecular weight of approximately 147 kDa as a dimer and multiple N-glycosylation sites, has yet been constructed.
34119424	5	9	theme	multiple	862:869	arg1	sites					887:891	approximately 147 kDa as a dimer and multiple N-glycosylation sites	825:891	approximately 147 kDa as a dimer and multiple N-glycosylation sites	825:891	However, no recombinant expression system for IgNAR, which has a molecular weight of approximately 147 kDa as a dimer and multiple N-glycosylation sites, has yet been constructed.
34119424	8	10	theme	fusion	1207:1212	arg1	protein					1214:1220	a human IgG Fc fusion protein	1192:1220	a human IgG Fc fusion protein	1192:1220	Using this system, IgNAR was successfully expressed and purified as a human IgG Fc fusion protein and showed antigen-binding ability.
34119424	8	10	theme	fusion	1207:1212	arg1	IgNAR					1143:1147	IgNAR	1143:1147	IgNAR	1143:1147	Using this system, IgNAR was successfully expressed and purified as a human IgG Fc fusion protein and showed antigen-binding ability.
34119424	3	11	contain	contains	490:497	arg2	concentration					506:518	a high concentration	499:518	a high concentration of urea to prevent water loss in seawater	499:560	IgNARs maintain their functions in the harsh environment of shark serum, which contains a high concentration of urea to prevent water loss in seawater.
34119424	3	11	contain	contains	490:497	arg1	functions					433:441	their functions	427:441	their functions	427:441	IgNARs maintain their functions in the harsh environment of shark serum, which contains a high concentration of urea to prevent water loss in seawater.
34119424	7	12	theme	CHO	1062:1064	arg1	cells					1067:1071	Chinese hamster ovary (CHO) cells	1039:1071	Chinese hamster ovary (CHO) cells	1039:1071	Here, we constructed a recombinant expression system for IgNAR using Chinese hamster ovary (CHO) cells, widely used as hosts for IgG antibody production.
34119424	1	13	theme	Cartilaginous	138:150	arg1	fishes					152:157	Cartilaginous fishes	138:157	Cartilaginous fishes such as sharks	138:172	Cartilaginous fishes such as sharks have adaptive immune systems based on immunoglobulins similar to those in mammals.
34119424	1	13	theme	Cartilaginous	138:150	arg1	sharks					167:172	sharks	167:172	sharks	167:172	Cartilaginous fishes such as sharks have adaptive immune systems based on immunoglobulins similar to those in mammals.
34119424	7	14	theme	ovary	1055:1059	arg1	cells					1067:1071	Chinese hamster ovary (CHO) cells	1039:1071	Chinese hamster ovary (CHO) cells	1039:1071	Here, we constructed a recombinant expression system for IgNAR using Chinese hamster ovary (CHO) cells, widely used as hosts for IgG antibody production.
34119424	7	15	theme	expression	1005:1014	arg1	system					1016:1021	a recombinant expression system	991:1021	a recombinant expression system for IgNAR	991:1031	Here, we constructed a recombinant expression system for IgNAR using Chinese hamster ovary (CHO) cells, widely used as hosts for IgG antibody production.
34119424	12	16	theme	IgNARs	1720:1725	arg1	development					1705:1715	the development	1701:1715	the development of IgNARs for industrial and biotechnological applications	1701:1774	This fundamental information will advance the development of IgNARs for industrial and biotechnological applications.
34119424	5	17	contain	has	799:801	arg1	system					775:780	no recombinant expression system	749:780	no recombinant expression system	749:780	However, no recombinant expression system for IgNAR, which has a molecular weight of approximately 147 kDa as a dimer and multiple N-glycosylation sites, has yet been constructed.
34119424	5	17	contain	has	799:801	arg2	weight					815:820	a molecular weight	803:820	a molecular weight of approximately 147 kDa as a dimer and multiple N-glycosylation sites	803:891	However, no recombinant expression system for IgNAR, which has a molecular weight of approximately 147 kDa as a dimer and multiple N-glycosylation sites, has yet been constructed.
34119424	0	18	theme	antibodies	75:84	arg1	Production					0:9	Production	0:9	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies	0:84	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system.
34119424	9	19	theme	A	1272:1272	arg1	purification					1283:1294	Protein A affinity purification	1264:1294	Protein A affinity purification	1264:1294	After Protein A affinity purification, followed by specific cleavage and removal of the human Fc-region, the final yield of IgNAR was 1.07 mg/L-medium.
34119424	4	20	used	used	636:639	arg2	IgNARs					574:579	IgNARs	574:579	IgNARs	574:579	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	4	20	used	used	636:639	arg2	antibodies					660:669	next-generation antibodies	644:669	next-generation antibodies in applications different from those of conventional IgG antibodies	644:737	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	10	21	theme	CHO	1425:1427	arg1	system					1445:1450	this CHO cell expression system	1420:1450	this CHO cell expression system	1420:1450	Moreover, this CHO cell expression system modified IgNAR with various N-glycans, including high-mannose and complex types.
34119424	4	22	theme	IgG	724:726	arg1	antibodies					728:737	conventional IgG antibodies	711:737	conventional IgG antibodies	711:737	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	0	23	theme	Chinese	92:98	arg1	ovary					108:112	Chinese hamster ovary	92:112	Chinese hamster ovary cell expression system	92:135	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system.
34119424	1	24	theme	adaptive	179:186	arg1	systems					195:201	adaptive immune systems	179:201	adaptive immune systems based on immunoglobulins similar to those in mammals	179:254	Cartilaginous fishes such as sharks have adaptive immune systems based on immunoglobulins similar to those in mammals.
34119424	0	25	theme	ovary	108:112	arg1	system					130:135	Chinese hamster ovary cell expression system	92:135	Chinese hamster ovary cell expression system	92:135	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system.
34119424	3	26	theme	shark	471:475	arg1	serum					477:481	shark serum	471:481	shark serum	471:481	IgNARs maintain their functions in the harsh environment of shark serum, which contains a high concentration of urea to prevent water loss in seawater.
34119424	0	27	theme	expression	119:128	arg1	system					130:135	Chinese hamster ovary cell expression system	92:135	Chinese hamster ovary cell expression system	92:135	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system.
34119424	9	28	theme	specific	1309:1316	arg1	cleavage					1318:1325	specific cleavage	1309:1325	specific cleavage	1309:1325	After Protein A affinity purification, followed by specific cleavage and removal of the human Fc-region, the final yield of IgNAR was 1.07 mg/L-medium.
34119424	10	29	theme	expression	1434:1443	arg1	system					1445:1450	this CHO cell expression system	1420:1450	this CHO cell expression system	1420:1450	Moreover, this CHO cell expression system modified IgNAR with various N-glycans, including high-mannose and complex types.
34119424	0	30	theme	monoclonal	14:23	arg1	antibodies					75:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system.
34119424	1	31	theme	immune	188:193	arg1	systems					195:201	adaptive immune systems	179:201	adaptive immune systems based on immunoglobulins similar to those in mammals	179:254	Cartilaginous fishes such as sharks have adaptive immune systems based on immunoglobulins similar to those in mammals.
34119424	9	32	theme	human	1346:1350	arg1	Fc-region					1352:1360	the human Fc-region	1342:1360	the human Fc-region	1342:1360	After Protein A affinity purification, followed by specific cleavage and removal of the human Fc-region, the final yield of IgNAR was 1.07 mg/L-medium.
34119424	0	33	theme	immunoglobulin	39:52	arg1	antibodies					75:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system.
34119424	2	34	theme	antigen	384:390	arg1	IgNARs					402:407	IgNARs	402:407	IgNARs	402:407	During their evolution, cartilaginous fishes individually have acquired their adaptive immune system called immunoglobulin new antigen receptor (IgNARs).
34119424	2	34	theme	antigen	384:390	arg1	receptor					392:399	immunoglobulin new antigen receptor	365:399	immunoglobulin new antigen receptor (IgNARs)	365:408	During their evolution, cartilaginous fishes individually have acquired their adaptive immune system called immunoglobulin new antigen receptor (IgNARs).
34119424	0	35	theme	antigen	58:64	arg1	antibodies					75:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system.
34119424	3	36	from	functions	433:441	arg1	environment					456:466	the harsh environment	446:466	the harsh environment of shark serum	446:481	IgNARs maintain their functions in the harsh environment of shark serum, which contains a high concentration of urea to prevent water loss in seawater.
34119424	2	37	theme	immunoglobulin	365:378	arg1	IgNARs					402:407	IgNARs	402:407	IgNARs	402:407	During their evolution, cartilaginous fishes individually have acquired their adaptive immune system called immunoglobulin new antigen receptor (IgNARs).
34119424	2	37	theme	immunoglobulin	365:378	arg1	receptor					392:399	immunoglobulin new antigen receptor	365:399	immunoglobulin new antigen receptor (IgNARs)	365:408	During their evolution, cartilaginous fishes individually have acquired their adaptive immune system called immunoglobulin new antigen receptor (IgNARs).
34119424	9	38	theme	final	1367:1371	arg1	mg/L-medium					1397:1407	1.07 mg/L-medium	1392:1407	1.07 mg/L-medium	1392:1407	After Protein A affinity purification, followed by specific cleavage and removal of the human Fc-region, the final yield of IgNAR was 1.07 mg/L-medium.
34119424	9	38	theme	final	1367:1371	arg1	yield					1373:1377	the final yield	1363:1377	the final yield of IgNAR	1363:1386	After Protein A affinity purification, followed by specific cleavage and removal of the human Fc-region, the final yield of IgNAR was 1.07 mg/L-medium.
34119424	3	39	theme	water	539:543	arg1	loss					545:548	water loss	539:548	water loss in seawater	539:560	IgNARs maintain their functions in the harsh environment of shark serum, which contains a high concentration of urea to prevent water loss in seawater.
34119424	0	40	theme	receptor	66:73	arg1	antibodies					75:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system.
34119424	11	41	theme	IgNAR	1652:1656	arg1	functions					1639:1647	biological functions	1628:1647	biological functions	1628:1647	This expression system will allow us to analyze the structure, physicochemical properties, and biological functions of IgNAR.
34119424	11	41	theme	IgNAR	1652:1656	arg1	structure					1585:1593	structure	1585:1593	structure	1585:1593	This expression system will allow us to analyze the structure, physicochemical properties, and biological functions of IgNAR.
34119424	11	41	theme	IgNAR	1652:1656	arg1	properties					1612:1621	physicochemical properties	1596:1621	physicochemical properties	1596:1621	This expression system will allow us to analyze the structure, physicochemical properties, and biological functions of IgNAR.
34119424	5	42	gly	N-glycosylation	871:885	arg2	sites					887:891	approximately 147 kDa as a dimer and multiple N-glycosylation sites	825:891	approximately 147 kDa as a dimer and multiple N-glycosylation sites	825:891	However, no recombinant expression system for IgNAR, which has a molecular weight of approximately 147 kDa as a dimer and multiple N-glycosylation sites, has yet been constructed.
34119424	0	43	link	shark-derived	25:37	arg1	antibodies					75:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system.
34119424	4	44	theme	structural	591:600	arg1	stability					602:610	high structural stability	586:610	high structural stability	586:610	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	7	45	theme	IgG	1099:1101	arg1	production					1112:1121	IgG antibody production	1099:1121	IgG antibody production	1099:1121	Here, we constructed a recombinant expression system for IgNAR using Chinese hamster ovary (CHO) cells, widely used as hosts for IgG antibody production.
34119424	4	46	from	those	702:706	arg1	different					687:695	different	687:695	different	687:695	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	1	47	contain	have	174:177	arg1	fishes					152:157	Cartilaginous fishes	138:157	Cartilaginous fishes such as sharks	138:172	Cartilaginous fishes such as sharks have adaptive immune systems based on immunoglobulins similar to those in mammals.
34119424	1	47	contain	have	174:177	arg1	sharks					167:172	sharks	167:172	sharks	167:172	Cartilaginous fishes such as sharks have adaptive immune systems based on immunoglobulins similar to those in mammals.
34119424	1	47	contain	have	174:177	arg2	systems					195:201	adaptive immune systems	179:201	adaptive immune systems based on immunoglobulins similar to those in mammals	179:254	Cartilaginous fishes such as sharks have adaptive immune systems based on immunoglobulins similar to those in mammals.
34119424	3	48	from	loss	545:548	arg1	seawater					553:560	seawater	553:560	seawater	553:560	IgNARs maintain their functions in the harsh environment of shark serum, which contains a high concentration of urea to prevent water loss in seawater.
34119424	5	49	theme	N-glycosylation	871:885	arg1	sites					887:891	approximately 147 kDa as a dimer and multiple N-glycosylation sites	825:891	approximately 147 kDa as a dimer and multiple N-glycosylation sites	825:891	However, no recombinant expression system for IgNAR, which has a molecular weight of approximately 147 kDa as a dimer and multiple N-glycosylation sites, has yet been constructed.
34119424	12	50	theme	industrial	1731:1740	arg1	applications					1763:1774	industrial and biotechnological applications	1731:1774	applications	1763:1774	This fundamental information will advance the development of IgNARs for industrial and biotechnological applications.
34119424	10	51	dep	high-mannose	1501:1512	arg1	types					1526:1530	types	1526:1530	types	1526:1530	Moreover, this CHO cell expression system modified IgNAR with various N-glycans, including high-mannose and complex types.
34119424	4	52	contain	have	581:584	arg1	IgNARs					574:579	IgNARs	574:579	IgNARs	574:579	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	4	52	contain	have	581:584	arg1	antibodies					660:669	next-generation antibodies	644:669	next-generation antibodies in applications different from those of conventional IgG antibodies	644:737	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	4	52	contain	have	581:584	arg2	stability					602:610	high structural stability	586:610	high structural stability	586:610	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	12	53	theme	biotechnological	1746:1761	arg1	applications					1763:1774	industrial and biotechnological applications	1731:1774	applications	1763:1774	This fundamental information will advance the development of IgNARs for industrial and biotechnological applications.
34119424	11	54	dep	structure	1585:1593	arg1	the					1581:1583	the	1581:1583	the	1581:1583	This expression system will allow us to analyze the structure, physicochemical properties, and biological functions of IgNAR.
34119424	4	55	theme	different	687:695	arg1	applications					674:685	applications	674:685	applications different from those of conventional IgG antibodies	674:737	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	2	56	theme	adaptive	335:342	arg1	system					351:356	their adaptive immune system	329:356	their adaptive immune system called immunoglobulin new antigen receptor (IgNARs)	329:408	During their evolution, cartilaginous fishes individually have acquired their adaptive immune system called immunoglobulin new antigen receptor (IgNARs).
34119424	2	57	theme	new	380:382	arg1	IgNARs					402:407	IgNARs	402:407	IgNARs	402:407	During their evolution, cartilaginous fishes individually have acquired their adaptive immune system called immunoglobulin new antigen receptor (IgNARs).
34119424	2	57	theme	new	380:382	arg1	receptor					392:399	immunoglobulin new antigen receptor	365:399	immunoglobulin new antigen receptor (IgNARs)	365:408	During their evolution, cartilaginous fishes individually have acquired their adaptive immune system called immunoglobulin new antigen receptor (IgNARs).
34119424	8	58	theme	human	1194:1198	arg1	protein					1214:1220	a human IgG Fc fusion protein	1192:1220	a human IgG Fc fusion protein	1192:1220	Using this system, IgNAR was successfully expressed and purified as a human IgG Fc fusion protein and showed antigen-binding ability.
34119424	8	58	theme	human	1194:1198	arg1	IgNAR					1143:1147	IgNAR	1143:1147	IgNAR	1143:1147	Using this system, IgNAR was successfully expressed and purified as a human IgG Fc fusion protein and showed antigen-binding ability.
34119424	4	59	theme	next-generation	644:658	arg1	IgNARs					574:579	IgNARs	574:579	IgNARs	574:579	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	4	59	theme	next-generation	644:658	arg1	antibodies					660:669	next-generation antibodies	644:669	next-generation antibodies in applications different from those of conventional IgG antibodies	644:737	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	7	60	theme	Chinese	1039:1045	arg1	cells					1067:1071	Chinese hamster ovary (CHO) cells	1039:1071	Chinese hamster ovary (CHO) cells	1039:1071	Here, we constructed a recombinant expression system for IgNAR using Chinese hamster ovary (CHO) cells, widely used as hosts for IgG antibody production.
34119424	8	61	theme	Fc	1204:1205	arg1	protein					1214:1220	a human IgG Fc fusion protein	1192:1220	a human IgG Fc fusion protein	1192:1220	Using this system, IgNAR was successfully expressed and purified as a human IgG Fc fusion protein and showed antigen-binding ability.
34119424	8	61	theme	Fc	1204:1205	arg1	IgNAR					1143:1147	IgNAR	1143:1147	IgNAR	1143:1147	Using this system, IgNAR was successfully expressed and purified as a human IgG Fc fusion protein and showed antigen-binding ability.
34119424	6	62	theme	IgNAR	951:955	arg1	development					957:967	IgNAR development	951:967	IgNAR development	951:967	This has stalled research into IgNAR development.
34119424	7	63	theme	hamster	1047:1053	arg1	cells					1067:1071	Chinese hamster ovary (CHO) cells	1039:1071	Chinese hamster ovary (CHO) cells	1039:1071	Here, we constructed a recombinant expression system for IgNAR using Chinese hamster ovary (CHO) cells, widely used as hosts for IgG antibody production.
34119424	2	64	theme	cartilaginous	281:293	arg1	fishes					295:300	cartilaginous fishes	281:300	cartilaginous fishes	281:300	During their evolution, cartilaginous fishes individually have acquired their adaptive immune system called immunoglobulin new antigen receptor (IgNARs).
34119424	10	65	with	IgNAR	1461:1465	arg1	complex					1518:1524	complex	1518:1524	complex	1518:1524	Moreover, this CHO cell expression system modified IgNAR with various N-glycans, including high-mannose and complex types.
34119424	10	65	with	IgNAR	1461:1465	arg1	N-glycans					1480:1488	various N-glycans	1472:1488	various N-glycans	1472:1488	Moreover, this CHO cell expression system modified IgNAR with various N-glycans, including high-mannose and complex types.
34119424	10	65	with	IgNAR	1461:1465	arg1	high-mannose					1501:1512	high-mannose	1501:1512	high-mannose	1501:1512	Moreover, this CHO cell expression system modified IgNAR with various N-glycans, including high-mannose and complex types.
34119424	3	66	theme	high	501:504	arg1	concentration					506:518	a high concentration	499:518	a high concentration of urea to prevent water loss in seawater	499:560	IgNARs maintain their functions in the harsh environment of shark serum, which contains a high concentration of urea to prevent water loss in seawater.
34119424	9	67	theme	Protein	1264:1270	arg1	purification					1283:1294	Protein A affinity purification	1264:1294	Protein A affinity purification	1264:1294	After Protein A affinity purification, followed by specific cleavage and removal of the human Fc-region, the final yield of IgNAR was 1.07 mg/L-medium.
34119424	5	68	theme	recombinant	752:762	arg1	system					775:780	no recombinant expression system	749:780	no recombinant expression system	749:780	However, no recombinant expression system for IgNAR, which has a molecular weight of approximately 147 kDa as a dimer and multiple N-glycosylation sites, has yet been constructed.
34119424	0	69	theme	hamster	100:106	arg1	ovary					108:112	Chinese hamster ovary	92:112	Chinese hamster ovary cell expression system	92:135	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system.
34119424	9	70	theme	affinity	1274:1281	arg1	purification					1283:1294	Protein A affinity purification	1264:1294	Protein A affinity purification	1264:1294	After Protein A affinity purification, followed by specific cleavage and removal of the human Fc-region, the final yield of IgNAR was 1.07 mg/L-medium.
34119424	7	71	theme	recombinant	993:1003	arg1	system					1016:1021	a recombinant expression system	991:1021	a recombinant expression system for IgNAR	991:1031	Here, we constructed a recombinant expression system for IgNAR using Chinese hamster ovary (CHO) cells, widely used as hosts for IgG antibody production.
34119424	12	72	theme	fundamental	1664:1674	arg1	information					1676:1686	This fundamental information	1659:1686	This fundamental information	1659:1686	This fundamental information will advance the development of IgNARs for industrial and biotechnological applications.
34119424	4	73	theme	conventional	711:722	arg1	antibodies					728:737	conventional IgG antibodies	711:737	conventional IgG antibodies	711:737	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	0	74	theme	cell	114:117	arg1	system					130:135	Chinese hamster ovary cell expression system	92:135	Chinese hamster ovary cell expression system	92:135	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system.
34119424	5	75	theme	expression	764:773	arg1	system					775:780	no recombinant expression system	749:780	no recombinant expression system	749:780	However, no recombinant expression system for IgNAR, which has a molecular weight of approximately 147 kDa as a dimer and multiple N-glycosylation sites, has yet been constructed.
34119424	3	76	theme	serum	477:481	arg1	environment					456:466	the harsh environment	446:466	the harsh environment of shark serum	446:481	IgNARs maintain their functions in the harsh environment of shark serum, which contains a high concentration of urea to prevent water loss in seawater.
34119424	10	77	theme	cell	1429:1432	arg1	system					1445:1450	this CHO cell expression system	1420:1450	this CHO cell expression system	1420:1450	Moreover, this CHO cell expression system modified IgNAR with various N-glycans, including high-mannose and complex types.
34119424	0	78	theme	shark-derived	25:37	arg1	antibodies					75:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system.
34119424	4	79	theme	high	586:589	arg1	stability					602:610	high structural stability	586:610	high structural stability	586:610	Therefore, IgNARs have high structural stability, and are expected to be used as next-generation antibodies in applications different from those of conventional IgG antibodies.
34119424	10	80	theme	various	1472:1478	arg1	complex					1518:1524	complex	1518:1524	complex	1518:1524	Moreover, this CHO cell expression system modified IgNAR with various N-glycans, including high-mannose and complex types.
34119424	10	80	theme	various	1472:1478	arg1	N-glycans					1480:1488	various N-glycans	1472:1488	various N-glycans	1472:1488	Moreover, this CHO cell expression system modified IgNAR with various N-glycans, including high-mannose and complex types.
34119424	10	80	theme	various	1472:1478	arg1	high-mannose					1501:1512	high-mannose	1501:1512	high-mannose	1501:1512	Moreover, this CHO cell expression system modified IgNAR with various N-glycans, including high-mannose and complex types.
34119424	0	81	theme	new	54:56	arg1	antibodies					75:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	monoclonal shark-derived immunoglobulin new antigen receptor antibodies	14:84	Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system.
34119424	3	82	theme	harsh	450:454	arg1	environment					456:466	the harsh environment	446:466	the harsh environment of shark serum	446:481	IgNARs maintain their functions in the harsh environment of shark serum, which contains a high concentration of urea to prevent water loss in seawater.
34119424	5	83	theme	molecular	805:813	arg1	weight					815:820	a molecular weight	803:820	a molecular weight of approximately 147 kDa as a dimer and multiple N-glycosylation sites	803:891	However, no recombinant expression system for IgNAR, which has a molecular weight of approximately 147 kDa as a dimer and multiple N-glycosylation sites, has yet been constructed.
34119424	9	84	theme	Fc-region	1352:1360	arg1	removal					1331:1337	removal	1331:1337	removal of the human Fc-region	1331:1360	After Protein A affinity purification, followed by specific cleavage and removal of the human Fc-region, the final yield of IgNAR was 1.07 mg/L-medium.
34119424	9	84	theme	Fc-region	1352:1360	arg1	cleavage					1318:1325	specific cleavage	1309:1325	specific cleavage	1309:1325	After Protein A affinity purification, followed by specific cleavage and removal of the human Fc-region, the final yield of IgNAR was 1.07 mg/L-medium.
34119424	3	85	theme	urea	523:526	arg1	concentration					506:518	a high concentration	499:518	a high concentration of urea to prevent water loss in seawater	499:560	IgNARs maintain their functions in the harsh environment of shark serum, which contains a high concentration of urea to prevent water loss in seawater.
34119424	11	86	theme	physicochemical	1596:1610	arg1	properties					1612:1621	physicochemical properties	1596:1621	physicochemical properties	1596:1621	This expression system will allow us to analyze the structure, physicochemical properties, and biological functions of IgNAR.
34119424	11	87	theme	biological	1628:1637	arg1	functions					1639:1647	biological functions	1628:1647	biological functions	1628:1647	This expression system will allow us to analyze the structure, physicochemical properties, and biological functions of IgNAR.
34119424	9	88	theme	IgNAR	1382:1386	arg1	mg/L-medium					1397:1407	1.07 mg/L-medium	1392:1407	1.07 mg/L-medium	1392:1407	After Protein A affinity purification, followed by specific cleavage and removal of the human Fc-region, the final yield of IgNAR was 1.07 mg/L-medium.
34119424	9	88	theme	IgNAR	1382:1386	arg1	yield					1373:1377	the final yield	1363:1377	the final yield of IgNAR	1363:1386	After Protein A affinity purification, followed by specific cleavage and removal of the human Fc-region, the final yield of IgNAR was 1.07 mg/L-medium.
34610426	2	0	from	effects	288:294	arg1	effectiveness					353:365	the pretreatment effectiveness	336:365	the pretreatment effectiveness	336:365	The effects of oxidant, bamboo ages, and species on the pretreatment effectiveness and subsequent enzymolysis were studied.
34610426	2	0	from	effects	288:294	arg1	enzymolysis					382:392	subsequent enzymolysis	371:392	subsequent enzymolysis	371:392	The effects of oxidant, bamboo ages, and species on the pretreatment effectiveness and subsequent enzymolysis were studied.
34610426	0	1	theme	ages	74:77	arg1	bamboo					56:61	bamboo	56:61	bamboo of various ages and species	56:89	Combined oxidization and liquid ammonia pretreatment of bamboo of various ages and species for maximizing fermentable sugar release.
34610426	3	2	theme	bamboo	663:668	arg1	100 g					650:654	100 g	650:654	100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample	650:745	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	2	3	theme	species	325:331	arg1	effects					288:294	The effects	284:294	The effects of oxidant, bamboo ages, and species on the pretreatment effectiveness and subsequent enzymolysis	284:392	The effects of oxidant, bamboo ages, and species on the pretreatment effectiveness and subsequent enzymolysis were studied.
34610426	5	4	theme	B-NA	951:954	arg1	enzymolysis					936:946	the enzymolysis	932:946	the enzymolysis of B-NA and B-BM	932:963	The OD-LAT pretreatment was only suitable for bamboo under three-year-old, and it significantly improved the enzymolysis of B-NA and B-BM, while it was limited to B-DO and B-PP.
34610426	5	5	theme	B-BM	960:963	arg1	enzymolysis					936:946	the enzymolysis	932:946	the enzymolysis of B-NA and B-BM	932:963	The OD-LAT pretreatment was only suitable for bamboo under three-year-old, and it significantly improved the enzymolysis of B-NA and B-BM, while it was limited to B-DO and B-PP.
34610426	3	6	theme	glucan	509:514	arg1	conversion					526:535	the glucan and xylan conversion	505:535	the glucan and xylan conversion	505:535	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	0	7	theme	species	83:89	arg1	bamboo					56:61	bamboo	56:61	bamboo of various ages and species	56:89	Combined oxidization and liquid ammonia pretreatment of bamboo of various ages and species for maximizing fermentable sugar release.
34610426	0	8	theme	fermentable	106:116	arg1	release					124:130	fermentable sugar release	106:130	fermentable sugar release	106:130	Combined oxidization and liquid ammonia pretreatment of bamboo of various ages and species for maximizing fermentable sugar release.
34610426	3	9	theme	xylan	520:524	arg1	conversion					526:535	the glucan and xylan conversion	505:535	the glucan and xylan conversion	505:535	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	6	10	theme	pretreatment	1009:1020	arg1	effects					1022:1028	The pretreatment effects	1005:1028	The pretreatment effects of bamboo	1005:1038	The pretreatment effects of bamboo were not only related to composition but also to the bamboo age, species, macro-structures and micro-structures.
34610426	6	10	theme	pretreatment	1009:1020	arg1	related					1054:1060	related	1054:1060	related	1054:1060	The pretreatment effects of bamboo were not only related to composition but also to the bamboo age, species, macro-structures and micro-structures.
34610426	3	11	theme	OD-LAT	426:431	arg1	pretreatment					433:444	the optimal OD-LAT pretreatment	414:444	the optimal OD-LAT pretreatment	414:444	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	1	12	theme	ammonia	229:235	arg1	pretreatment					237:248	liquid ammonia pretreatment	222:248	liquid ammonia pretreatment (OD-LAT)	222:257	To determine the potential for improving biomass enzymolysis, a combined oxidization and liquid ammonia pretreatment (OD-LAT) was employed for bamboo.
34610426	1	12	theme	ammonia	229:235	arg1	OD-LAT					251:256	OD-LAT	251:256	OD-LAT	251:256	To determine the potential for improving biomass enzymolysis, a combined oxidization and liquid ammonia pretreatment (OD-LAT) was employed for bamboo.
34610426	1	13	theme	biomass	174:180	arg1	enzymolysis					182:192	biomass enzymolysis	174:192	biomass enzymolysis	174:192	To determine the potential for improving biomass enzymolysis, a combined oxidization and liquid ammonia pretreatment (OD-LAT) was employed for bamboo.
34610426	6	14	theme	bamboo	1093:1098	arg1	age					1100:1102	the bamboo age	1089:1102	the bamboo age	1089:1102	The pretreatment effects of bamboo were not only related to composition but also to the bamboo age, species, macro-structures and micro-structures.
34610426	5	15	theme	OD-LAT	831:836	arg1	suitable					860:867	suitable	860:867	suitable	860:867	The OD-LAT pretreatment was only suitable for bamboo under three-year-old, and it significantly improved the enzymolysis of B-NA and B-BM, while it was limited to B-DO and B-PP.
34610426	5	15	theme	OD-LAT	831:836	arg1	pretreatment					838:849	The OD-LAT pretreatment	827:849	The OD-LAT pretreatment	827:849	The OD-LAT pretreatment was only suitable for bamboo under three-year-old, and it significantly improved the enzymolysis of B-NA and B-BM, while it was limited to B-DO and B-PP.
34610426	0	16	theme	Combined	0:7	arg1	oxidization					9:19	Combined oxidization	0:19	Combined oxidization	0:19	Combined oxidization and liquid ammonia pretreatment of bamboo of various ages and species for maximizing fermentable sugar release.
34610426	4	17	theme	OD-LAT	811:816	arg1	process					818:824	the OD-LAT process	807:824	the OD-LAT process	807:824	The H2O2 loading of 1.0 was the optimal oxidant dosage for the OD-LAT process.
34610426	2	18	theme	oxidant	299:305	arg1	effects					288:294	The effects	284:294	The effects of oxidant, bamboo ages, and species on the pretreatment effectiveness and subsequent enzymolysis	284:392	The effects of oxidant, bamboo ages, and species on the pretreatment effectiveness and subsequent enzymolysis were studied.
34610426	3	19	theme	optimal	418:424	arg1	pretreatment					433:444	the optimal OD-LAT pretreatment	414:444	the optimal OD-LAT pretreatment	414:444	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	0	20	theme	liquid	25:30	arg1	pretreatment					40:51	liquid ammonia pretreatment	25:51	liquid ammonia pretreatment	25:51	Combined oxidization and liquid ammonia pretreatment of bamboo of various ages and species for maximizing fermentable sugar release.
34610426	3	21	theme	untreated	730:738	arg1	sample					740:745	untreated sample	730:745	untreated sample	730:745	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	3	22	dep	glucan	509:514	arg1	the					505:507	the	505:507	the	505:507	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	0	23	theme	sugar	118:122	arg1	release					124:130	fermentable sugar release	106:130	fermentable sugar release	106:130	Combined oxidization and liquid ammonia pretreatment of bamboo of various ages and species for maximizing fermentable sugar release.
34610426	6	24	theme	bamboo	1033:1038	arg1	effects					1022:1028	The pretreatment effects	1005:1028	The pretreatment effects of bamboo	1005:1038	The pretreatment effects of bamboo were not only related to composition but also to the bamboo age, species, macro-structures and micro-structures.
34610426	6	24	theme	bamboo	1033:1038	arg1	related					1054:1060	related	1054:1060	related	1054:1060	The pretreatment effects of bamboo were not only related to composition but also to the bamboo age, species, macro-structures and micro-structures.
34610426	1	25	theme	combined	197:204	arg1	oxidization					206:216	a combined oxidization	195:216	a combined oxidization	195:216	To determine the potential for improving biomass enzymolysis, a combined oxidization and liquid ammonia pretreatment (OD-LAT) was employed for bamboo.
34610426	4	26	theme	optimal	780:786	arg1	loading					757:763	The H2O2 loading	748:763	The H2O2 loading of 1.0	748:770	The H2O2 loading of 1.0 was the optimal oxidant dosage for the OD-LAT process.
34610426	4	26	theme	optimal	780:786	arg1	dosage					796:801	the optimal oxidant dosage	776:801	the optimal oxidant dosage for the OD-LAT process	776:824	The H2O2 loading of 1.0 was the optimal oxidant dosage for the OD-LAT process.
34610426	0	27	theme	ammonia	32:38	arg1	pretreatment					40:51	liquid ammonia pretreatment	25:51	liquid ammonia pretreatment	25:51	Combined oxidization and liquid ammonia pretreatment of bamboo of various ages and species for maximizing fermentable sugar release.
34610426	3	28	theme	sugars	623:628	arg1	59.7-68.5 g					596:606	59.7-68.5 g	596:606	59.7-68.5 g	596:606	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	3	28	theme	sugars	623:628	arg1	sugars					623:628	fermentable sugars	611:628	fermentable sugars	611:628	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	0	29	theme	bamboo	56:61	arg1	pretreatment					40:51	liquid ammonia pretreatment	25:51	liquid ammonia pretreatment	25:51	Combined oxidization and liquid ammonia pretreatment of bamboo of various ages and species for maximizing fermentable sugar release.
34610426	0	29	theme	bamboo	56:61	arg1	oxidization					9:19	Combined oxidization	0:19	Combined oxidization	0:19	Combined oxidization and liquid ammonia pretreatment of bamboo of various ages and species for maximizing fermentable sugar release.
34610426	3	30	theme	Neosinocalamus	481:494	arg1	affinis					496:502	the B-NA bamboo Neosinocalamus affinis	465:502	the B-NA bamboo Neosinocalamus affinis	465:502	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	4	31	theme	oxidant	788:794	arg1	loading					757:763	The H2O2 loading	748:763	The H2O2 loading of 1.0	748:770	The H2O2 loading of 1.0 was the optimal oxidant dosage for the OD-LAT process.
34610426	4	31	theme	oxidant	788:794	arg1	dosage					796:801	the optimal oxidant dosage	776:801	the optimal oxidant dosage for the OD-LAT process	776:824	The H2O2 loading of 1.0 was the optimal oxidant dosage for the OD-LAT process.
34610426	3	32	theme	affinis	496:502	arg1	enzymolysis					450:460	enzymolysis	450:460	enzymolysis	450:460	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	3	32	theme	affinis	496:502	arg1	pretreatment					433:444	the optimal OD-LAT pretreatment	414:444	the optimal OD-LAT pretreatment	414:444	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	3	33	dep	fold	702:705	arg1	5-8					698:700	5-8	698:700	5-8	698:700	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	3	34	theme	dry	659:661	arg1	bamboo					663:668	dry bamboo	659:668	dry bamboo	659:668	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	3	34	theme	dry	659:661	arg1	increase					707:714	an approximately 5-8 fold increase	681:714	an approximately 5-8 fold increase compared with untreated sample	681:745	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	2	35	theme	ages	315:318	arg1	effects					288:294	The effects	284:294	The effects of oxidant, bamboo ages, and species on the pretreatment effectiveness and subsequent enzymolysis	284:392	The effects of oxidant, bamboo ages, and species on the pretreatment effectiveness and subsequent enzymolysis were studied.
34610426	1	36	theme	liquid	222:227	arg1	pretreatment					237:248	liquid ammonia pretreatment	222:248	liquid ammonia pretreatment (OD-LAT)	222:257	To determine the potential for improving biomass enzymolysis, a combined oxidization and liquid ammonia pretreatment (OD-LAT) was employed for bamboo.
34610426	1	36	theme	liquid	222:227	arg1	OD-LAT					251:256	OD-LAT	251:256	OD-LAT	251:256	To determine the potential for improving biomass enzymolysis, a combined oxidization and liquid ammonia pretreatment (OD-LAT) was employed for bamboo.
34610426	4	37	theme	H2O2	752:755	arg1	loading					757:763	The H2O2 loading	748:763	The H2O2 loading of 1.0	748:770	The H2O2 loading of 1.0 was the optimal oxidant dosage for the OD-LAT process.
34610426	4	37	theme	H2O2	752:755	arg1	dosage					796:801	the optimal oxidant dosage	776:801	the optimal oxidant dosage for the OD-LAT process	776:824	The H2O2 loading of 1.0 was the optimal oxidant dosage for the OD-LAT process.
34610426	3	38	theme	fermentable	611:621	arg1	sugars					623:628	fermentable sugars	611:628	fermentable sugars	611:628	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	3	39	theme	bamboo	474:479	arg1	affinis					496:502	the B-NA bamboo Neosinocalamus affinis	465:502	the B-NA bamboo Neosinocalamus affinis	465:502	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	3	40	theme	B-NA	469:472	arg1	affinis					496:502	the B-NA bamboo Neosinocalamus affinis	465:502	the B-NA bamboo Neosinocalamus affinis	465:502	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	0	41	theme	various	66:72	arg1	ages					74:77	various ages	66:77	various ages	66:77	Combined oxidization and liquid ammonia pretreatment of bamboo of various ages and species for maximizing fermentable sugar release.
34610426	2	42	theme	pretreatment	340:351	arg1	effectiveness					353:365	the pretreatment effectiveness	336:365	the pretreatment effectiveness	336:365	The effects of oxidant, bamboo ages, and species on the pretreatment effectiveness and subsequent enzymolysis were studied.
34610426	2	43	theme	subsequent	371:380	arg1	enzymolysis					382:392	subsequent enzymolysis	371:392	subsequent enzymolysis	371:392	The effects of oxidant, bamboo ages, and species on the pretreatment effectiveness and subsequent enzymolysis were studied.
34610426	3	44	dep	increase	707:714	arg1	fold					702:705	fold	702:705	fold	702:705	Under the optimal OD-LAT pretreatment and enzymolysis of the B-NA bamboo Neosinocalamus affinis, the glucan and xylan conversion reached 83.85% and 78.66%, respectively, and approximately 59.7-68.5 g of fermentable sugars can be produced per 100 g of dry bamboo, which was an approximately 5-8 fold increase compared with untreated sample.
34610426	4	45	theme	1.0	768:770	arg1	loading					757:763	The H2O2 loading	748:763	The H2O2 loading of 1.0	748:770	The H2O2 loading of 1.0 was the optimal oxidant dosage for the OD-LAT process.
34610426	4	45	theme	1.0	768:770	arg1	dosage					796:801	the optimal oxidant dosage	776:801	the optimal oxidant dosage for the OD-LAT process	776:824	The H2O2 loading of 1.0 was the optimal oxidant dosage for the OD-LAT process.
34668091	0	0	theme	Nasal	97:101	arg1	Route					103:107	Nasal Route	97:107	Nasal Route	97:107	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.
34668091	5	1	theme	ex	754:755	arg1	studies					773:779	ex vivo permeation studies	754:779	ex vivo permeation studies	754:779	The composite was characterized by FTIR, XRD, NMR, and MS. Further, this composite was converted into a nanoformulation by the ionic-gelation method, characterized, and subjected to ex vivo permeation studies.
34668091	7	2	theme	targeting	962:970	arg1	efficacy					972:979	The targeting efficacy	958:979	The targeting efficacy	958:979	The targeting efficacy was predicted by molecular docking studies against receptors associated with BBB.
34668091	1	3	theme	neurological	163:174	arg1	disorders					176:184	neurological disorders	163:184	neurological disorders	163:184	The major challenge associated with the treatment of neurological disorders is the inefficiency of drugs to enter the Central Nervous System (CNS).
34668091	11	4	theme	CTC	1619:1621	arg1	nanocomposite-485.375 μg/mL					1623:1649	CTC nanocomposite-485.375 μg/mL	1619:1649	CTC nanocomposite-485.375 μg/mL	1619:1649	MTT assay showed that the nanocomposite had lesser toxicity compared to the free drug (IC50 of Centella-269.1 μg/mL and IC50 of CTC nanocomposite-485.375 μg/mL).
34668091	9	5	dep	size	1241:1244	arg1	the					1237:1239	the	1237:1239	the	1237:1239	Nanocomposite characterization through SEM, AFM, and DLS confirmed the size and stability of the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260.
34668091	9	6	dep	potential	1305:1313	arg1	of - 14.5 mV					1315:1326	of - 14.5 mV	1315:1326	of - 14.5 mV	1315:1326	Nanocomposite characterization through SEM, AFM, and DLS confirmed the size and stability of the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260.
34668091	12	7	theme	docking	1711:1717	arg1	studies					1719:1725	docking studies	1711:1725	docking studies	1711:1725	The affinity of polymer to the BBB receptors as proved by docking studies suggests the ability of polymer-based nanocomposite to concentrate in the brain post nasal administration.
34668091	1	8	theme	disorders	176:184	arg1	treatment					150:158	the treatment	146:158	the treatment of neurological disorders	146:184	The major challenge associated with the treatment of neurological disorders is the inefficiency of drugs to enter the Central Nervous System (CNS).
34668091	12	9	theme	nasal	1812:1816	arg1	administration					1818:1831	nasal administration	1812:1831	nasal administration	1812:1831	The affinity of polymer to the BBB receptors as proved by docking studies suggests the ability of polymer-based nanocomposite to concentrate in the brain post nasal administration.
34668091	6	10	theme	Blood-Brain	890:900	arg1	Barrier					902:908	Blood-Brain Barrier	890:908	Blood-Brain Barrier (BBB)	890:914	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	6	10	theme	Blood-Brain	890:900	arg1	BBB					911:913	BBB	911:913	BBB	911:913	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	10	11	theme	permeation	1412:1421	arg1	signs					1374:1378	no signs	1371:1378	no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa	1371:1488	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	11	12	theme	free	1567:1570	arg1	drug					1572:1575	the free drug	1563:1575	the free drug (IC50 of Centella-269.1 μg/mL and IC50 of CTC nanocomposite-485.375 μg/mL)	1563:1650	MTT assay showed that the nanocomposite had lesser toxicity compared to the free drug (IC50 of Centella-269.1 μg/mL and IC50 of CTC nanocomposite-485.375 μg/mL).
34668091	9	13	theme	developed	1267:1275	arg1	nanocomposite					1277:1289	the developed nanocomposite	1263:1289	the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260	1263:1343	Nanocomposite characterization through SEM, AFM, and DLS confirmed the size and stability of the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260.
34668091	9	14	theme	nanocomposite	1277:1289	arg1	stability					1250:1258	stability	1250:1258	stability	1250:1258	Nanocomposite characterization through SEM, AFM, and DLS confirmed the size and stability of the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260.
34668091	9	14	theme	nanocomposite	1277:1289	arg1	size					1241:1244	size	1241:1244	size	1241:1244	Nanocomposite characterization through SEM, AFM, and DLS confirmed the size and stability of the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260.
34668091	10	15	theme	good	1407:1410	arg1	permeation					1412:1421	good permeation	1407:1421	good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa	1407:1488	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	6	16	theme	MTT	796:798	arg1	assay					800:804	MTT assay	796:804	MTT assay	796:804	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	11	17	dep	drug	1572:1575	arg1	IC50					1578:1581	IC50	1578:1581	IC50 of Centella-269.1 μg/mL	1578:1605	MTT assay showed that the nanocomposite had lesser toxicity compared to the free drug (IC50 of Centella-269.1 μg/mL and IC50 of CTC nanocomposite-485.375 μg/mL).
34668091	11	17	dep	drug	1572:1575	arg1	IC50					1611:1614	IC50	1611:1614	IC50 of CTC nanocomposite-485.375 μg/mL	1611:1649	MTT assay showed that the nanocomposite had lesser toxicity compared to the free drug (IC50 of Centella-269.1 μg/mL and IC50 of CTC nanocomposite-485.375 μg/mL).
34668091	8	18	theme	chitosan	1146:1153	arg1	conjugation					1121:1131	the chemical conjugation	1108:1131	the chemical conjugation of thiolated chitosan with Centella	1108:1167	The FTIR, XRD, NMR, and MS studies confirmed the chemical conjugation of thiolated chitosan with Centella.
34668091	4	19	theme	Thiolated	479:487	arg1	chitosan					489:496	Thiolated chitosan	479:496	Thiolated chitosan	479:496	Thiolated chitosan was complexed with Centella to form a composite using EDAC hydrochloride.
34668091	9	20	theme	Nanocomposite	1170:1182	arg1	characterization					1184:1199	Nanocomposite characterization	1170:1199	Nanocomposite characterization through SEM, AFM, and DLS	1170:1225	Nanocomposite characterization through SEM, AFM, and DLS confirmed the size and stability of the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260.
34668091	11	21	theme	Centella-269.1 μg/mL	1586:1605	arg1	IC50					1578:1581	IC50	1578:1581	IC50 of Centella-269.1 μg/mL	1578:1605	MTT assay showed that the nanocomposite had lesser toxicity compared to the free drug (IC50 of Centella-269.1 μg/mL and IC50 of CTC nanocomposite-485.375 μg/mL).
34668091	11	21	theme	Centella-269.1 μg/mL	1586:1605	arg1	IC50					1611:1614	IC50	1611:1614	IC50 of CTC nanocomposite-485.375 μg/mL	1611:1649	MTT assay showed that the nanocomposite had lesser toxicity compared to the free drug (IC50 of Centella-269.1 μg/mL and IC50 of CTC nanocomposite-485.375 μg/mL).
34668091	0	22	theme	Potential	54:62	arg1	Strategy					80:87	A Potential Brain Targeting Strategy	52:87	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.	0:108	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.
34668091	6	23	theme	cord	843:846	arg1	HUVECs					872:877	HUVECs	872:877	HUVECs	872:877	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	6	23	theme	cord	843:846	arg1	Cells					865:869	Human Uumbilical cord Vein Endothelial Cells	826:869	Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB)	826:914	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	0	24	theme	Thiolated	0:8	arg1	Nanocomposite					37:49	Thiolated Chitosan-Centella asiatica Nanocomposite	0:49	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.	0:108	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.
34668091	3	25	theme	Centella	458:465	arg1	delivery					446:453	enhanced delivery	437:453	enhanced delivery of Centella to the CNS	437:476	The study aimed at developing polymer hybrid nasal nanocomposite for enhanced delivery of Centella to the CNS.
34668091	0	26	theme	Chitosan-Centella	10:26	arg1	Nanocomposite					37:49	Thiolated Chitosan-Centella asiatica Nanocomposite	0:49	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.	0:108	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.
34668091	9	27	theme	zeta	1300:1303	arg1	potential					1305:1313	a zeta potential of - 14.5 mV and PDI	1298:1334	potential	1305:1313	Nanocomposite characterization through SEM, AFM, and DLS confirmed the size and stability of the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260.
34668091	12	28	theme	nanocomposite	1765:1777	arg1	ability					1740:1746	the ability	1736:1746	the ability of polymer-based nanocomposite to concentrate in the brain post nasal administration	1736:1831	The affinity of polymer to the BBB receptors as proved by docking studies suggests the ability of polymer-based nanocomposite to concentrate in the brain post nasal administration.
34668091	10	29	theme	ciliotoxicity	1389:1401	arg1	signs					1374:1378	no signs	1371:1378	no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa	1371:1488	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	11	30	theme	nanocomposite-485.375 μg/mL	1623:1649	arg1	IC50					1578:1581	IC50	1578:1581	IC50 of Centella-269.1 μg/mL	1578:1605	MTT assay showed that the nanocomposite had lesser toxicity compared to the free drug (IC50 of Centella-269.1 μg/mL and IC50 of CTC nanocomposite-485.375 μg/mL).
34668091	11	30	theme	nanocomposite-485.375 μg/mL	1623:1649	arg1	IC50					1611:1614	IC50	1611:1614	IC50 of CTC nanocomposite-485.375 μg/mL	1611:1649	MTT assay showed that the nanocomposite had lesser toxicity compared to the free drug (IC50 of Centella-269.1 μg/mL and IC50 of CTC nanocomposite-485.375 μg/mL).
34668091	3	31	theme	enhanced	437:444	arg1	delivery					446:453	enhanced delivery	437:453	enhanced delivery of Centella to the CNS	437:476	The study aimed at developing polymer hybrid nasal nanocomposite for enhanced delivery of Centella to the CNS.
34668091	3	32	theme	polymer	398:404	arg1	nanocomposite					419:431	polymer hybrid nasal nanocomposite	398:431	polymer hybrid nasal nanocomposite for enhanced delivery of Centella to the CNS	398:476	The study aimed at developing polymer hybrid nasal nanocomposite for enhanced delivery of Centella to the CNS.
34668091	10	33	from	permeation	1412:1421	arg1	8 h					1462:1464	8 h	1462:1464	8 h across the nasal mucosa	1462:1488	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	10	34	theme	%	1438:1438	arg1	ciliotoxicity					1389:1401	nasal ciliotoxicity	1383:1401	nasal ciliotoxicity	1383:1401	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	10	34	theme	%	1438:1438	arg1	permeation					1412:1421	good permeation	1407:1421	good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa	1407:1488	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	10	35	theme	nasal	1383:1387	arg1	ciliotoxicity					1389:1401	nasal ciliotoxicity	1383:1401	nasal ciliotoxicity	1383:1401	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	8	36	theme	chemical	1112:1119	arg1	conjugation					1121:1131	the chemical conjugation	1108:1131	the chemical conjugation of thiolated chitosan with Centella	1108:1167	The FTIR, XRD, NMR, and MS studies confirmed the chemical conjugation of thiolated chitosan with Centella.
34668091	10	37	from	ciliotoxicity	1389:1401	arg1	8 h					1462:1464	8 h	1462:1464	8 h across the nasal mucosa	1462:1488	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	6	38	theme	nanocomposite	943:955	arg1	safety					933:938	the safety	929:938	the safety of nanocomposite	929:955	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	5	39	dep	ex	754:755	arg1	vivo					757:760	vivo	757:760	vivo	757:760	The composite was characterized by FTIR, XRD, NMR, and MS. Further, this composite was converted into a nanoformulation by the ionic-gelation method, characterized, and subjected to ex vivo permeation studies.
34668091	8	40	with	conjugation	1121:1131	arg1	Centella					1160:1167	Centella	1160:1167	Centella	1160:1167	The FTIR, XRD, NMR, and MS studies confirmed the chemical conjugation of thiolated chitosan with Centella.
34668091	1	41	theme	drugs	209:213	arg1	inefficiency					193:204	the inefficiency	189:204	the inefficiency of drugs	189:213	The major challenge associated with the treatment of neurological disorders is the inefficiency of drugs to enter the Central Nervous System (CNS).
34668091	1	41	theme	drugs	209:213	arg1	challenge					120:128	The major challenge	110:128	The major challenge associated with the treatment of neurological disorders	110:184	The major challenge associated with the treatment of neurological disorders is the inefficiency of drugs to enter the Central Nervous System (CNS).
34668091	0	42	theme	asiatica	28:35	arg1	Nanocomposite					37:49	Thiolated Chitosan-Centella asiatica Nanocomposite	0:49	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.	0:108	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.
34668091	8	43	theme	FTIR	1067:1070	arg1	NMR					1078:1080	The FTIR, XRD, NMR, and MS studies	1063:1096	NMR	1078:1080	The FTIR, XRD, NMR, and MS studies confirmed the chemical conjugation of thiolated chitosan with Centella.
34668091	1	44	theme	major	114:118	arg1	inefficiency					193:204	the inefficiency	189:204	the inefficiency of drugs	189:213	The major challenge associated with the treatment of neurological disorders is the inefficiency of drugs to enter the Central Nervous System (CNS).
34668091	1	44	theme	major	114:118	arg1	challenge					120:128	The major challenge	110:128	The major challenge associated with the treatment of neurological disorders	110:184	The major challenge associated with the treatment of neurological disorders is the inefficiency of drugs to enter the Central Nervous System (CNS).
34668091	9	45	contain	having	1291:1296	arg2	potential					1305:1313	a zeta potential of - 14.5 mV and PDI	1298:1334	potential	1305:1313	Nanocomposite characterization through SEM, AFM, and DLS confirmed the size and stability of the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260.
34668091	9	45	contain	having	1291:1296	arg2	PDI					1332:1334	PDI	1332:1334	PDI	1332:1334	Nanocomposite characterization through SEM, AFM, and DLS confirmed the size and stability of the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260.
34668091	9	45	contain	having	1291:1296	arg1	nanocomposite					1277:1289	the developed nanocomposite	1263:1289	the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260	1263:1343	Nanocomposite characterization through SEM, AFM, and DLS confirmed the size and stability of the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260.
34668091	5	46	theme	permeation	762:771	arg1	studies					773:779	ex vivo permeation studies	754:779	ex vivo permeation studies	754:779	The composite was characterized by FTIR, XRD, NMR, and MS. Further, this composite was converted into a nanoformulation by the ionic-gelation method, characterized, and subjected to ex vivo permeation studies.
34668091	5	47	theme	ionic-gelation	699:712	arg1	method					714:719	the ionic-gelation method	695:719	the ionic-gelation method	695:719	The composite was characterized by FTIR, XRD, NMR, and MS. Further, this composite was converted into a nanoformulation by the ionic-gelation method, characterized, and subjected to ex vivo permeation studies.
34668091	6	48	theme	Endothelial	853:863	arg1	HUVECs					872:877	HUVECs	872:877	HUVECs	872:877	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	6	48	theme	Endothelial	853:863	arg1	Cells					865:869	Human Uumbilical cord Vein Endothelial Cells	826:869	Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB)	826:914	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	6	49	theme	Vein	848:851	arg1	HUVECs					872:877	HUVECs	872:877	HUVECs	872:877	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	6	49	theme	Vein	848:851	arg1	Cells					865:869	Human Uumbilical cord Vein Endothelial Cells	826:869	Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB)	826:914	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	11	50	contain	had	1531:1533	arg1	nanocomposite					1517:1529	the nanocomposite	1513:1529	the nanocomposite	1513:1529	MTT assay showed that the nanocomposite had lesser toxicity compared to the free drug (IC50 of Centella-269.1 μg/mL and IC50 of CTC nanocomposite-485.375 μg/mL).
34668091	11	50	contain	had	1531:1533	arg2	toxicity					1542:1549	lesser toxicity	1535:1549	lesser toxicity	1535:1549	MTT assay showed that the nanocomposite had lesser toxicity compared to the free drug (IC50 of Centella-269.1 μg/mL and IC50 of CTC nanocomposite-485.375 μg/mL).
34668091	7	51	theme	molecular	998:1006	arg1	studies					1016:1022	molecular docking studies	998:1022	molecular docking studies against receptors associated with BBB	998:1060	The targeting efficacy was predicted by molecular docking studies against receptors associated with BBB.
34668091	8	52	theme	thiolated	1136:1144	arg1	chitosan					1146:1153	thiolated chitosan	1136:1153	thiolated chitosan	1136:1153	The FTIR, XRD, NMR, and MS studies confirmed the chemical conjugation of thiolated chitosan with Centella.
34668091	3	53	theme	hybrid	406:411	arg1	nanocomposite					419:431	polymer hybrid nasal nanocomposite	398:431	polymer hybrid nasal nanocomposite for enhanced delivery of Centella to the CNS	398:476	The study aimed at developing polymer hybrid nasal nanocomposite for enhanced delivery of Centella to the CNS.
34668091	9	54	theme	0.260	1339:1343	arg1	potential					1305:1313	a zeta potential of - 14.5 mV and PDI	1298:1334	potential	1305:1313	Nanocomposite characterization through SEM, AFM, and DLS confirmed the size and stability of the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260.
34668091	9	54	theme	0.260	1339:1343	arg1	PDI					1332:1334	PDI	1332:1334	PDI	1332:1334	Nanocomposite characterization through SEM, AFM, and DLS confirmed the size and stability of the developed nanocomposite having a zeta potential of - 14.5 mV and PDI of 0.260.
34668091	0	55	theme	Targeting	70:78	arg1	Strategy					80:87	A Potential Brain Targeting Strategy	52:87	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.	0:108	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.
34668091	7	56	theme	docking	1008:1014	arg1	studies					1016:1022	molecular docking studies	998:1022	molecular docking studies against receptors associated with BBB	998:1060	The targeting efficacy was predicted by molecular docking studies against receptors associated with BBB.
34668091	2	57	theme	conventional	348:359	arg1	drugs					361:365	conventional drugs	348:365	conventional drugs	348:365	Polymer-drug conjugates are now being tailored to overcome this hindrance associated with conventional drugs.
34668091	3	58	theme	nasal	413:417	arg1	nanocomposite					419:431	polymer hybrid nasal nanocomposite	398:431	polymer hybrid nasal nanocomposite for enhanced delivery of Centella to the CNS	398:476	The study aimed at developing polymer hybrid nasal nanocomposite for enhanced delivery of Centella to the CNS.
34668091	4	59	theme	EDAC	552:555	arg1	hydrochloride					557:569	EDAC hydrochloride	552:569	EDAC hydrochloride	552:569	Thiolated chitosan was complexed with Centella to form a composite using EDAC hydrochloride.
34668091	10	60	theme	nasal	1477:1481	arg1	mucosa					1483:1488	the nasal mucosa	1473:1488	the nasal mucosa	1473:1488	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	6	61	theme	Uumbilical	832:841	arg1	HUVECs					872:877	HUVECs	872:877	HUVECs	872:877	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	6	61	theme	Uumbilical	832:841	arg1	Cells					865:869	Human Uumbilical cord Vein Endothelial Cells	826:869	Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB)	826:914	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	6	62	theme	Human	826:830	arg1	HUVECs					872:877	HUVECs	872:877	HUVECs	872:877	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	6	62	theme	Human	826:830	arg1	Cells					865:869	Human Uumbilical cord Vein Endothelial Cells	826:869	Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB)	826:914	Additionally, MTT assay was performed using Human Uumbilical cord Vein Endothelial Cells (HUVECs) mimicking Blood-Brain Barrier (BBB) to establish the safety of nanocomposite.
34668091	11	63	theme	lesser	1535:1540	arg1	toxicity					1542:1549	lesser toxicity	1535:1549	lesser toxicity	1535:1549	MTT assay showed that the nanocomposite had lesser toxicity compared to the free drug (IC50 of Centella-269.1 μg/mL and IC50 of CTC nanocomposite-485.375 μg/mL).
34668091	12	64	theme	polymer	1669:1675	arg1	affinity					1657:1664	The affinity	1653:1664	The affinity of polymer to the BBB receptors as proved by docking studies	1653:1725	The affinity of polymer to the BBB receptors as proved by docking studies suggests the ability of polymer-based nanocomposite to concentrate in the brain post nasal administration.
34668091	8	65	theme	MS	1087:1088	arg1	studies					1090:1096	The FTIR, XRD, NMR, and MS studies	1063:1096	studies	1090:1096	The FTIR, XRD, NMR, and MS studies confirmed the chemical conjugation of thiolated chitosan with Centella.
34668091	0	66	dep	Nanocomposite	37:49	arg1	Strategy					80:87	A Potential Brain Targeting Strategy	52:87	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.	0:108	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.
34668091	2	67	theme	Polymer-drug	258:269	arg1	conjugates					271:280	Polymer-drug conjugates	258:280	Polymer-drug conjugates	258:280	Polymer-drug conjugates are now being tailored to overcome this hindrance associated with conventional drugs.
34668091	1	68	theme	Central	228:234	arg1	System					244:249	the Central Nervous System	224:249	the Central Nervous System (CNS)	224:255	The major challenge associated with the treatment of neurological disorders is the inefficiency of drugs to enter the Central Nervous System (CNS).
34668091	1	68	theme	Central	228:234	arg1	CNS					252:254	CNS	252:254	CNS	252:254	The major challenge associated with the treatment of neurological disorders is the inefficiency of drugs to enter the Central Nervous System (CNS).
34668091	1	69	theme	Nervous	236:242	arg1	System					244:249	the Central Nervous System	224:249	the Central Nervous System (CNS)	224:255	The major challenge associated with the treatment of neurological disorders is the inefficiency of drugs to enter the Central Nervous System (CNS).
34668091	1	69	theme	Nervous	236:242	arg1	CNS					252:254	CNS	252:254	CNS	252:254	The major challenge associated with the treatment of neurological disorders is the inefficiency of drugs to enter the Central Nervous System (CNS).
34668091	10	70	from	8 h	1462:1464	arg1	ciliotoxicity					1389:1401	nasal ciliotoxicity	1383:1401	nasal ciliotoxicity	1383:1401	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	10	70	from	8 h	1462:1464	arg1	permeation					1412:1421	good permeation	1407:1421	good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa	1407:1488	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	10	70	from	8 h	1462:1464	arg1	%					1438:1438	89.44 ± 1.75%	1426:1438	89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa	1426:1488	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	0	71	theme	Brain	64:68	arg1	Strategy					80:87	A Potential Brain Targeting Strategy	52:87	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.	0:108	Thiolated Chitosan-Centella asiatica Nanocomposite: A Potential Brain Targeting Strategy Through Nasal Route.
34668091	10	72	dep	%	1438:1438	arg1	n = 3					1452:1456	n = 3	1452:1456	n = 3	1452:1456	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	10	72	dep	%	1438:1438	arg1	mean ± SD					1441:1449	mean ± SD	1441:1449	mean ± SD	1441:1449	The nanocomposite showed no signs of nasal ciliotoxicity and good permeation of 89.44 ± 1.75% (mean ± SD, n = 3) at 8 h across the nasal mucosa.
34668091	8	73	dep	NMR	1078:1080	arg1	XRD					1073:1075	The FTIR, XRD, NMR, and MS studies	1063:1096	XRD	1073:1075	The FTIR, XRD, NMR, and MS studies confirmed the chemical conjugation of thiolated chitosan with Centella.
34668091	12	74	theme	polymer-based	1751:1763	arg1	nanocomposite					1765:1777	polymer-based nanocomposite	1751:1777	polymer-based nanocomposite	1751:1777	The affinity of polymer to the BBB receptors as proved by docking studies suggests the ability of polymer-based nanocomposite to concentrate in the brain post nasal administration.
34668091	12	75	theme	BBB	1684:1686	arg1	receptors					1688:1696	the BBB receptors	1680:1696	the BBB receptors as proved by docking studies	1680:1725	The affinity of polymer to the BBB receptors as proved by docking studies suggests the ability of polymer-based nanocomposite to concentrate in the brain post nasal administration.
34668091	11	76	theme	MTT	1491:1493	arg1	assay					1495:1499	MTT assay	1491:1499	MTT assay	1491:1499	MTT assay showed that the nanocomposite had lesser toxicity compared to the free drug (IC50 of Centella-269.1 μg/mL and IC50 of CTC nanocomposite-485.375 μg/mL).
34742429	2	0	theme	film-forming	501:512	arg1	matrix					514:519	CS-based film-forming matrix	492:519	CS-based film-forming matrix	492:519	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	5	1	theme	composite	792:800	arg1	films					802:806	composite films	792:806	composite films	792:806	Concretely, the water contact angle and inhibition zone of composite films can increase by about 12.3° and 2 times compared with CS control film.
34742429	1	2	theme	limited	172:178	arg1	activity					194:201	limited antibacterial activity	172:201	limited antibacterial activity of chitosan (CS)	172:218	The low water-resistance and limited antibacterial activity of chitosan (CS) film hinder its practical applications in food preservation field.
34742429	1	2	theme	limited	172:178	arg1	CS					216:217	CS	216:217	CS	216:217	The low water-resistance and limited antibacterial activity of chitosan (CS) film hinder its practical applications in food preservation field.
34742429	3	3	from	distribution	553:564	arg1	matrix					595:600	film matrix	590:600	film matrix	590:600	Research results show the well distribution of emulsion droplets in film matrix.
34742429	1	4	theme	food	262:265	arg1	field					280:284	food preservation field	262:284	food preservation field	262:284	The low water-resistance and limited antibacterial activity of chitosan (CS) film hinder its practical applications in food preservation field.
34742429	2	5	theme	CS-based	492:499	arg1	matrix					514:519	CS-based film-forming matrix	492:519	CS-based film-forming matrix	492:519	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	6	6	theme	film	921:924	arg1	strength					934:941	film tensile strength	921:941	film tensile strength	921:941	Compared with tween-80, CNCs can increase film tensile strength by about 3.52 MPa and observably offset the decline of film mechanical property by CEO.
34742429	1	7	theme	antibacterial	180:192	arg1	activity					194:201	limited antibacterial activity	172:201	limited antibacterial activity of chitosan (CS)	172:218	The low water-resistance and limited antibacterial activity of chitosan (CS) film hinder its practical applications in food preservation field.
34742429	1	7	theme	antibacterial	180:192	arg1	CS					216:217	CS	216:217	CS	216:217	The low water-resistance and limited antibacterial activity of chitosan (CS) film hinder its practical applications in food preservation field.
34742429	1	8	theme	preservation	267:278	arg1	field					280:284	food preservation field	262:284	food preservation field	262:284	The low water-resistance and limited antibacterial activity of chitosan (CS) film hinder its practical applications in food preservation field.
34742429	5	9	theme	contact	755:761	arg1	angle					763:767	water contact angle	749:767	water contact angle	749:767	Concretely, the water contact angle and inhibition zone of composite films can increase by about 12.3° and 2 times compared with CS control film.
34742429	7	10	theme	Pickering	1098:1106	arg1	emulsion					1108:1115	30 v/v% CEO Pickering emulsion	1086:1115	30 v/v% CEO Pickering emulsion	1086:1115	Moreover, the film prepared with 3 w/v% CNC stabilized 30 v/v% CEO Pickering emulsion not only enhances pork preservation, but also maintain its structural stability.
34742429	6	11	theme	film	998:1001	arg1	property					1014:1021	film mechanical property	998:1021	film mechanical property	998:1021	Compared with tween-80, CNCs can increase film tensile strength by about 3.52 MPa and observably offset the decline of film mechanical property by CEO.
34742429	5	12	theme	inhibition	773:782	arg1	zone					784:787	inhibition zone	773:787	inhibition zone	773:787	Concretely, the water contact angle and inhibition zone of composite films can increase by about 12.3° and 2 times compared with CS control film.
34742429	3	13	theme	emulsion	569:576	arg1	droplets					578:585	emulsion droplets	569:585	emulsion droplets	569:585	Research results show the well distribution of emulsion droplets in film matrix.
34742429	2	14	theme	oil	373:375	arg1	films					400:404	cinnamon essential oil (CEO)-loaded composite films	354:404	cinnamon essential oil (CEO)-loaded composite films	354:404	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	0	15	theme	composite	126:134	arg1	films					136:140	chitosan composite films	117:140	chitosan composite films	117:140	Effect of cellulose nanocrystal-stabilized cinnamon essential oil Pickering emulsions on structure and properties of chitosan composite films.
34742429	7	16	theme	%	1092:1092	arg1	emulsion					1108:1115	30 v/v% CEO Pickering emulsion	1086:1115	30 v/v% CEO Pickering emulsion	1086:1115	Moreover, the film prepared with 3 w/v% CNC stabilized 30 v/v% CEO Pickering emulsion not only enhances pork preservation, but also maintain its structural stability.
34742429	4	17	theme	film	646:649	arg1	water-resistance					651:666	film water-resistance	646:666	film water-resistance	646:666	The insertion of CEO emulsions can improve film water-resistance and antibacterial activity, but reduces its mechanical strength.
34742429	3	18	theme	well	548:551	arg1	distribution					553:564	the well distribution	544:564	the well distribution of emulsion droplets in film matrix	544:600	Research results show the well distribution of emulsion droplets in film matrix.
34742429	2	19	theme	-loaded	382:388	arg1	films					400:404	cinnamon essential oil (CEO)-loaded composite films	354:404	cinnamon essential oil (CEO)-loaded composite films	354:404	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	0	20	theme	chitosan	117:124	arg1	films					136:140	chitosan composite films	117:140	chitosan composite films	117:140	Effect of cellulose nanocrystal-stabilized cinnamon essential oil Pickering emulsions on structure and properties of chitosan composite films.
34742429	6	21	theme	property	1014:1021	arg1	decline					987:993	the decline	983:993	the decline of film mechanical property by CEO	983:1028	Compared with tween-80, CNCs can increase film tensile strength by about 3.52 MPa and observably offset the decline of film mechanical property by CEO.
34742429	4	22	theme	CEO	620:622	arg1	emulsions					624:632	CEO emulsions	620:632	CEO emulsions	620:632	The insertion of CEO emulsions can improve film water-resistance and antibacterial activity, but reduces its mechanical strength.
34742429	2	23	theme	composite	390:398	arg1	films					400:404	cinnamon essential oil (CEO)-loaded composite films	354:404	cinnamon essential oil (CEO)-loaded composite films	354:404	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	2	24	theme	-stabilized	451:461	arg1	emulsions					477:485	cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions	424:485	cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions	424:485	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	5	25	theme	films	802:806	arg1	angle					763:767	water contact angle	749:767	water contact angle	749:767	Concretely, the water contact angle and inhibition zone of composite films can increase by about 12.3° and 2 times compared with CS control film.
34742429	5	25	theme	films	802:806	arg1	zone					784:787	inhibition zone	773:787	inhibition zone	773:787	Concretely, the water contact angle and inhibition zone of composite films can increase by about 12.3° and 2 times compared with CS control film.
34742429	3	26	theme	film	590:593	arg1	matrix					595:600	film matrix	590:600	film matrix	590:600	Research results show the well distribution of emulsion droplets in film matrix.
34742429	1	27	theme	chitosan	206:213	arg1	activity					194:201	limited antibacterial activity	172:201	limited antibacterial activity of chitosan (CS)	172:218	The low water-resistance and limited antibacterial activity of chitosan (CS) film hinder its practical applications in food preservation field.
34742429	1	27	theme	chitosan	206:213	arg1	CS					216:217	CS	216:217	CS	216:217	The low water-resistance and limited antibacterial activity of chitosan (CS) film hinder its practical applications in food preservation field.
34742429	1	27	theme	chitosan	206:213	arg1	water-resistance					151:166	The low water-resistance	143:166	The low water-resistance	143:166	The low water-resistance and limited antibacterial activity of chitosan (CS) film hinder its practical applications in food preservation field.
34742429	7	28	theme	30 v/v	1086:1091	arg1	%					1092:1092	%	1092:1092	%	1092:1092	Moreover, the film prepared with 3 w/v% CNC stabilized 30 v/v% CEO Pickering emulsion not only enhances pork preservation, but also maintain its structural stability.
34742429	7	29	theme	3 w/v	1064:1068	arg1	CNC					1071:1073	3 w/v% CNC	1064:1073	3 w/v% CNC stabilized 30 v/v% CEO Pickering emulsion	1064:1115	Moreover, the film prepared with 3 w/v% CNC stabilized 30 v/v% CEO Pickering emulsion not only enhances pork preservation, but also maintain its structural stability.
34742429	2	30	theme	CNC	447:449	arg1	emulsions					477:485	cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions	424:485	cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions	424:485	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	7	31	theme	%	1069:1069	arg1	CNC					1071:1073	3 w/v% CNC	1064:1073	3 w/v% CNC stabilized 30 v/v% CEO Pickering emulsion	1064:1115	Moreover, the film prepared with 3 w/v% CNC stabilized 30 v/v% CEO Pickering emulsion not only enhances pork preservation, but also maintain its structural stability.
34742429	1	32	dep	water-resistance	151:166	arg1	film					220:223	film	220:223	film	220:223	The low water-resistance and limited antibacterial activity of chitosan (CS) film hinder its practical applications in food preservation field.
34742429	2	33	theme	nanocrystal	434:444	arg1	emulsions					477:485	cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions	424:485	cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions	424:485	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	0	34	theme	cellulose	10:18	arg1	Effect					0:5	Effect	0:5	Effect of cellulose	0:18	Effect of cellulose nanocrystal-stabilized cinnamon essential oil Pickering emulsions on structure and properties of chitosan composite films.
34742429	0	35	theme	films	136:140	arg1	structure					89:97	structure	89:97	structure	89:97	Effect of cellulose nanocrystal-stabilized cinnamon essential oil Pickering emulsions on structure and properties of chitosan composite films.
34742429	0	35	theme	films	136:140	arg1	properties					103:112	properties	103:112	properties of chitosan composite films	103:140	Effect of cellulose nanocrystal-stabilized cinnamon essential oil Pickering emulsions on structure and properties of chitosan composite films.
34742429	2	36	theme	essential	363:371	arg1	oil					373:375	cinnamon essential oil	354:375	cinnamon essential oil (CEO)-loaded composite films	354:404	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	2	36	theme	essential	363:371	arg1	CEO					378:380	CEO	378:380	CEO	378:380	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	6	37	theme	tensile	926:932	arg1	strength					934:941	film tensile strength	921:941	film tensile strength	921:941	Compared with tween-80, CNCs can increase film tensile strength by about 3.52 MPa and observably offset the decline of film mechanical property by CEO.
34742429	2	38	theme	cellulose	424:432	arg1	emulsions					477:485	cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions	424:485	cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions	424:485	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	0	39	theme	essential	52:60	arg1	emulsions					76:84	cinnamon essential oil Pickering emulsions	43:84	cinnamon essential oil Pickering emulsions	43:84	Effect of cellulose nanocrystal-stabilized cinnamon essential oil Pickering emulsions on structure and properties of chitosan composite films.
34742429	5	40	theme	CS	862:863	arg1	film					873:876	CS control film	862:876	CS control film	862:876	Concretely, the water contact angle and inhibition zone of composite films can increase by about 12.3° and 2 times compared with CS control film.
34742429	4	41	theme	antibacterial	672:684	arg1	activity					686:693	antibacterial activity	672:693	antibacterial activity	672:693	The insertion of CEO emulsions can improve film water-resistance and antibacterial activity, but reduces its mechanical strength.
34742429	0	42	theme	cinnamon	43:50	arg1	emulsions					76:84	cinnamon essential oil Pickering emulsions	43:84	cinnamon essential oil Pickering emulsions	43:84	Effect of cellulose nanocrystal-stabilized cinnamon essential oil Pickering emulsions on structure and properties of chitosan composite films.
34742429	5	43	theme	water	749:753	arg1	angle					763:767	water contact angle	749:767	water contact angle	749:767	Concretely, the water contact angle and inhibition zone of composite films can increase by about 12.3° and 2 times compared with CS control film.
34742429	6	44	theme	mechanical	1003:1012	arg1	property					1014:1021	film mechanical property	998:1021	film mechanical property	998:1021	Compared with tween-80, CNCs can increase film tensile strength by about 3.52 MPa and observably offset the decline of film mechanical property by CEO.
34742429	8	45	contain	have	1233:1236	arg1	films					1227:1231	The fabricated antimicrobial films	1198:1231	The fabricated antimicrobial films	1198:1231	The fabricated antimicrobial films have considerable potential for packaging application.
34742429	8	45	contain	have	1233:1236	arg2	potential					1251:1259	considerable potential	1238:1259	considerable potential	1238:1259	The fabricated antimicrobial films have considerable potential for packaging application.
34742429	5	46	theme	control	865:871	arg1	film					873:876	CS control film	862:876	CS control film	862:876	Concretely, the water contact angle and inhibition zone of composite films can increase by about 12.3° and 2 times compared with CS control film.
34742429	2	47	theme	Pickering	467:475	arg1	emulsions					477:485	cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions	424:485	cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions	424:485	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	3	48	theme	Research	522:529	arg1	results					531:537	Research results	522:537	Research results	522:537	Research results show the well distribution of emulsion droplets in film matrix.
34742429	1	49	from	applications	246:257	arg1	field					280:284	food preservation field	262:284	food preservation field	262:284	The low water-resistance and limited antibacterial activity of chitosan (CS) film hinder its practical applications in food preservation field.
34742429	2	50	theme	cinnamon	354:361	arg1	oil					373:375	cinnamon essential oil	354:375	cinnamon essential oil (CEO)-loaded composite films	354:404	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	2	50	theme	cinnamon	354:361	arg1	CEO					378:380	CEO	378:380	CEO	378:380	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	0	51	theme	oil	62:64	arg1	emulsions					76:84	cinnamon essential oil Pickering emulsions	43:84	cinnamon essential oil Pickering emulsions	43:84	Effect of cellulose nanocrystal-stabilized cinnamon essential oil Pickering emulsions on structure and properties of chitosan composite films.
34742429	2	52	theme	CEO	463:465	arg1	emulsions					477:485	cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions	424:485	cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions	424:485	To solve these issues, we have facilely and effectively fabricated cinnamon essential oil (CEO)-loaded composite films via incorporating cellulose nanocrystal (CNC)-stabilized CEO Pickering emulsions into CS-based film-forming matrix.
34742429	7	53	theme	CEO	1094:1096	arg1	emulsion					1108:1115	30 v/v% CEO Pickering emulsion	1086:1115	30 v/v% CEO Pickering emulsion	1086:1115	Moreover, the film prepared with 3 w/v% CNC stabilized 30 v/v% CEO Pickering emulsion not only enhances pork preservation, but also maintain its structural stability.
34742429	8	54	theme	fabricated	1202:1211	arg1	films					1227:1231	The fabricated antimicrobial films	1198:1231	The fabricated antimicrobial films	1198:1231	The fabricated antimicrobial films have considerable potential for packaging application.
34742429	8	55	theme	antimicrobial	1213:1225	arg1	films					1227:1231	The fabricated antimicrobial films	1198:1231	The fabricated antimicrobial films	1198:1231	The fabricated antimicrobial films have considerable potential for packaging application.
34742429	7	56	theme	pork	1135:1138	arg1	preservation					1140:1151	pork preservation	1135:1151	pork preservation	1135:1151	Moreover, the film prepared with 3 w/v% CNC stabilized 30 v/v% CEO Pickering emulsion not only enhances pork preservation, but also maintain its structural stability.
34742429	8	57	theme	packaging	1265:1273	arg1	application					1275:1285	packaging application	1265:1285	packaging application	1265:1285	The fabricated antimicrobial films have considerable potential for packaging application.
34742429	3	58	theme	droplets	578:585	arg1	distribution					553:564	the well distribution	544:564	the well distribution of emulsion droplets in film matrix	544:600	Research results show the well distribution of emulsion droplets in film matrix.
34742429	4	59	theme	emulsions	624:632	arg1	insertion					607:615	The insertion	603:615	The insertion of CEO emulsions	603:632	The insertion of CEO emulsions can improve film water-resistance and antibacterial activity, but reduces its mechanical strength.
34742429	5	60	dep	angle	763:767	arg1	the					745:747	the	745:747	the	745:747	Concretely, the water contact angle and inhibition zone of composite films can increase by about 12.3° and 2 times compared with CS control film.
34742429	1	61	theme	low	147:149	arg1	water-resistance					151:166	The low water-resistance	143:166	The low water-resistance	143:166	The low water-resistance and limited antibacterial activity of chitosan (CS) film hinder its practical applications in food preservation field.
34742429	1	62	theme	practical	236:244	arg1	applications					246:257	its practical applications	232:257	its practical applications in food preservation field	232:284	The low water-resistance and limited antibacterial activity of chitosan (CS) film hinder its practical applications in food preservation field.
34742429	4	63	theme	mechanical	712:721	arg1	strength					723:730	its mechanical strength	708:730	its mechanical strength	708:730	The insertion of CEO emulsions can improve film water-resistance and antibacterial activity, but reduces its mechanical strength.
34742429	8	64	theme	considerable	1238:1249	arg1	potential					1251:1259	considerable potential	1238:1259	considerable potential	1238:1259	The fabricated antimicrobial films have considerable potential for packaging application.
34742429	0	65	theme	Pickering	66:74	arg1	emulsions					76:84	cinnamon essential oil Pickering emulsions	43:84	cinnamon essential oil Pickering emulsions	43:84	Effect of cellulose nanocrystal-stabilized cinnamon essential oil Pickering emulsions on structure and properties of chitosan composite films.
34742429	7	66	theme	structural	1176:1185	arg1	stability					1187:1195	its structural stability	1172:1195	its structural stability	1172:1195	Moreover, the film prepared with 3 w/v% CNC stabilized 30 v/v% CEO Pickering emulsion not only enhances pork preservation, but also maintain its structural stability.
33545814	10	0	theme	homogeneous	1817:1827	arg1	cartilage					1837:1845	homogeneous tubular cartilage	1817:1845	homogeneous tubular cartilage	1817:1845	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	11	1	theme	cell-seeding	2089:2100	arg1	strategy					2102:2109	a versatile and efficient cell-seeding strategy	2063:2109	a versatile and efficient cell-seeding strategy for regeneration of various tissue	2063:2144	Our findings establish a versatile and efficient cell-seeding strategy for regeneration of various tissue and provide a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects.
33545814	4	2	theme	low	611:613	arg1	adhesion					620:627	the very low cell adhesion	602:627	the very low cell adhesion of LDTM	602:635	However, as a result of the very low cell adhesion of LDTM, an overly high concentration of seeding cell is required, which greatly restricts its clinical translation.
33545814	7	3	theme	inherent	1136:1143	arg1	groups					1151:1156	inherent amino groups	1136:1156	inherent amino groups on LDTM surfaces	1136:1173	Moreover, the photo-generated aldehyde groups in PNH could rapidly react with inherent amino groups on LDTM surfaces to form imine bonds, which efficiently immobilized the cell-PNH composite to the surfaces of LDTM and/or maintained the composite in the LDTM micropores.
33545814	2	4	theme	ideal	273:277	arg1	trachea					279:285	an ideal trachea substitute	270:296	an ideal trachea substitute with biological function	270:321	The key to solving this problem is to develop an ideal trachea substitute with biological function.
33545814	0	5	link	Photocrosslinked	0:15	arg1	hydrogel					25:32	Photocrosslinked natural hydrogel	0:32	Photocrosslinked natural hydrogel composed of hyaluronic acid and gelatin	0:72	Photocrosslinked natural hydrogel composed of hyaluronic acid and gelatin enhances cartilage regeneration of decellularized trachea matrix.
33545814	4	6	theme	cell	678:681	arg1	concentration					653:665	an overly high concentration	638:665	an overly high concentration of seeding cell	638:681	However, as a result of the very low cell adhesion of LDTM, an overly high concentration of seeding cell is required, which greatly restricts its clinical translation.
33545814	4	6	theme	cell	678:681	arg1	result					592:597	a result	590:597	a result of the very low cell adhesion of LDTM	590:635	However, as a result of the very low cell adhesion of LDTM, an overly high concentration of seeding cell is required, which greatly restricts its clinical translation.
33545814	2	7	theme	biological	303:312	arg1	function					314:321	biological function	303:321	biological function	303:321	The key to solving this problem is to develop an ideal trachea substitute with biological function.
33545814	10	8	theme	accurate	1884:1891	arg1	shape					1902:1906	an accurate tracheal shape	1881:1906	an accurate tracheal shape	1881:1906	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	5	9	theme	natural	838:844	arg1	carrier					861:867	a photocrosslinked natural hydrogel (PNH) carrier	819:867	a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration	819:948	To address this issue, the current study proposed a novel strategy using a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration.
33545814	11	10	theme	functional	2207:2216	arg1	reconstruction					2218:2231	functional reconstruction	2207:2231	functional reconstruction	2207:2231	Our findings establish a versatile and efficient cell-seeding strategy for regeneration of various tissue and provide a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects.
33545814	4	11	theme	high	648:651	arg1	concentration					653:665	an overly high concentration	638:665	an overly high concentration of seeding cell	638:681	However, as a result of the very low cell adhesion of LDTM, an overly high concentration of seeding cell is required, which greatly restricts its clinical translation.
33545814	4	11	theme	high	648:651	arg1	result					592:597	a result	590:597	a result of the very low cell adhesion of LDTM	590:635	However, as a result of the very low cell adhesion of LDTM, an overly high concentration of seeding cell is required, which greatly restricts its clinical translation.
33545814	7	12	theme	aldehyde	1088:1095	arg1	groups					1097:1102	the photo-generated aldehyde groups	1068:1102	the photo-generated aldehyde groups in PNH	1068:1109	Moreover, the photo-generated aldehyde groups in PNH could rapidly react with inherent amino groups on LDTM surfaces to form imine bonds, which efficiently immobilized the cell-PNH composite to the surfaces of LDTM and/or maintained the composite in the LDTM micropores.
33545814	11	13	theme	defects	2260:2266	arg1	repair					2196:2201	repair	2196:2201	repair	2196:2201	Our findings establish a versatile and efficient cell-seeding strategy for regeneration of various tissue and provide a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects.
33545814	11	13	theme	defects	2260:2266	arg1	reconstruction					2218:2231	functional reconstruction	2207:2231	functional reconstruction	2207:2231	Our findings establish a versatile and efficient cell-seeding strategy for regeneration of various tissue and provide a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects.
33545814	10	14	theme	sufficient	1909:1918	arg1	strength					1931:1938	sufficient mechanical strength	1909:1938	sufficient mechanical strength	1909:1938	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	11	15	theme	segmental	2241:2249	arg1	defects					2260:2266	long segmental tracheal defects	2236:2266	long segmental tracheal defects	2236:2266	Our findings establish a versatile and efficient cell-seeding strategy for regeneration of various tissue and provide a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects.
33545814	11	16	theme	tissue	2139:2144	arg1	regeneration					2115:2126	regeneration	2115:2126	regeneration of various tissue	2115:2144	Our findings establish a versatile and efficient cell-seeding strategy for regeneration of various tissue and provide a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects.
33545814	4	17	theme	clinical	724:731	arg1	translation					733:743	its clinical translation	720:743	its clinical translation	720:743	However, as a result of the very low cell adhesion of LDTM, an overly high concentration of seeding cell is required, which greatly restricts its clinical translation.
33545814	5	18	theme	cartilage	927:935	arg1	regeneration					937:948	tracheal cartilage regeneration	918:948	tracheal cartilage regeneration	918:948	To address this issue, the current study proposed a novel strategy using a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration.
33545814	6	19	theme	ultraviolet	1039:1049	arg1	light					1051:1055	ultraviolet light	1039:1055	ultraviolet light	1039:1055	Our results demonstrated that PNH underwent a rapid liquid-solid phase conversion under ultraviolet light.
33545814	7	20	from	groups	1097:1102	arg1	PNH					1107:1109	PNH	1107:1109	PNH	1107:1109	Moreover, the photo-generated aldehyde groups in PNH could rapidly react with inherent amino groups on LDTM surfaces to form imine bonds, which efficiently immobilized the cell-PNH composite to the surfaces of LDTM and/or maintained the composite in the LDTM micropores.
33545814	10	21	theme	good	1941:1944	arg1	elasticity					1946:1955	good elasticity	1941:1955	good elasticity	1941:1955	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	5	22	theme	cell	880:883	arg1	efficiency					895:904	cell retention efficiency	880:904	cell retention efficiency	880:904	To address this issue, the current study proposed a novel strategy using a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration.
33545814	2	23	dep	trachea	279:285	arg1	substitute					287:296	substitute	287:296	substitute	287:296	The key to solving this problem is to develop an ideal trachea substitute with biological function.
33545814	0	24	theme	cartilage	83:91	arg1	regeneration					93:104	cartilage regeneration	83:104	cartilage regeneration of decellularized trachea matrix	83:137	Photocrosslinked natural hydrogel composed of hyaluronic acid and gelatin enhances cartilage regeneration of decellularized trachea matrix.
33545814	9	25	theme	three-dimensional	1581:1597	arg1	microenvironment					1610:1625	a natural three-dimensional biomimetic microenvironment	1571:1625	a natural three-dimensional biomimetic microenvironment to efficiently promote chondrocyte survival and proliferation, extracellular matrix production, and cartilage regeneration	1571:1748	Moreover, PNH exhibited excellent biocompatibility and low cytotoxicity, and provided a natural three-dimensional biomimetic microenvironment to efficiently promote chondrocyte survival and proliferation, extracellular matrix production, and cartilage regeneration.
33545814	6	26	theme	liquid-solid	1003:1014	arg1	conversion					1022:1031	a rapid liquid-solid phase conversion	995:1031	a rapid liquid-solid phase conversion	995:1031	Our results demonstrated that PNH underwent a rapid liquid-solid phase conversion under ultraviolet light.
33545814	8	27	theme	cell-seeding	1367:1378	arg1	efficiency					1380:1389	cell-seeding efficiency	1367:1389	cell-seeding efficiency	1367:1389	Therefore, PNH significantly enhanced cell-seeding efficiency and achieved both stable cell retention and homogenous cell distribution throughout the LDTM.
33545814	1	28	theme	long	150:153	arg1	defects					173:179	long segmental trachea defects	150:179	long segmental trachea defects	150:179	Repair of long segmental trachea defects is always a great challenge in the clinic.
33545814	3	29	theme	decellularized	335:348	arg1	matrix					358:363	a decellularized trachea matrix	333:363	a decellularized trachea matrix based on laser micropore technique (LDTM)	333:405	Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for tissue-engineered trachea regeneration.
33545814	0	30	theme	trachea	124:130	arg1	matrix					132:137	decellularized trachea matrix	109:137	decellularized trachea matrix	109:137	Photocrosslinked natural hydrogel composed of hyaluronic acid and gelatin enhances cartilage regeneration of decellularized trachea matrix.
33545814	0	31	theme	hyaluronic	46:55	arg1	acid					57:60	hyaluronic acid	46:60	hyaluronic acid	46:60	Photocrosslinked natural hydrogel composed of hyaluronic acid and gelatin enhances cartilage regeneration of decellularized trachea matrix.
33545814	9	32	theme	natural	1573:1579	arg1	microenvironment					1610:1625	a natural three-dimensional biomimetic microenvironment	1571:1625	a natural three-dimensional biomimetic microenvironment to efficiently promote chondrocyte survival and proliferation, extracellular matrix production, and cartilage regeneration	1571:1748	Moreover, PNH exhibited excellent biocompatibility and low cytotoxicity, and provided a natural three-dimensional biomimetic microenvironment to efficiently promote chondrocyte survival and proliferation, extracellular matrix production, and cartilage regeneration.
33545814	0	33	theme	Photocrosslinked	0:15	arg1	hydrogel					25:32	Photocrosslinked natural hydrogel	0:32	Photocrosslinked natural hydrogel composed of hyaluronic acid and gelatin	0:72	Photocrosslinked natural hydrogel composed of hyaluronic acid and gelatin enhances cartilage regeneration of decellularized trachea matrix.
33545814	9	34	theme	chondrocyte	1650:1660	arg1	survival					1662:1669	chondrocyte survival	1650:1669	chondrocyte survival	1650:1669	Moreover, PNH exhibited excellent biocompatibility and low cytotoxicity, and provided a natural three-dimensional biomimetic microenvironment to efficiently promote chondrocyte survival and proliferation, extracellular matrix production, and cartilage regeneration.
33545814	8	35	theme	cell	1416:1419	arg1	retention					1421:1429	stable cell retention	1409:1429	stable cell retention	1409:1429	Therefore, PNH significantly enhanced cell-seeding efficiency and achieved both stable cell retention and homogenous cell distribution throughout the LDTM.
33545814	7	36	theme	imine	1183:1187	arg1	bonds					1189:1193	imine bonds	1183:1193	imine bonds	1183:1193	Moreover, the photo-generated aldehyde groups in PNH could rapidly react with inherent amino groups on LDTM surfaces to form imine bonds, which efficiently immobilized the cell-PNH composite to the surfaces of LDTM and/or maintained the composite in the LDTM micropores.
33545814	3	37	theme	ideal	449:453	arg1	trachea					455:461	ideal trachea	449:461	ideal trachea	449:461	Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for tissue-engineered trachea regeneration.
33545814	7	38	theme	LDTM	1312:1315	arg1	micropores					1317:1326	the LDTM micropores	1308:1326	the LDTM micropores	1308:1326	Moreover, the photo-generated aldehyde groups in PNH could rapidly react with inherent amino groups on LDTM surfaces to form imine bonds, which efficiently immobilized the cell-PNH composite to the surfaces of LDTM and/or maintained the composite in the LDTM micropores.
33545814	10	39	theme	lacuna	1966:1971	arg1	structure					1973:1981	typical lacuna structure	1958:1981	typical lacuna structure	1958:1981	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	8	40	theme	cell	1446:1449	arg1	distribution					1451:1462	homogenous cell distribution	1435:1462	homogenous cell distribution	1435:1462	Therefore, PNH significantly enhanced cell-seeding efficiency and achieved both stable cell retention and homogenous cell distribution throughout the LDTM.
33545814	7	41	theme	LDTM	1161:1164	arg1	surfaces					1166:1173	LDTM surfaces	1161:1173	LDTM surfaces	1161:1173	Moreover, the photo-generated aldehyde groups in PNH could rapidly react with inherent amino groups on LDTM surfaces to form imine bonds, which efficiently immobilized the cell-PNH composite to the surfaces of LDTM and/or maintained the composite in the LDTM micropores.
33545814	9	42	theme	matrix	1704:1709	arg1	production					1711:1720	extracellular matrix production	1690:1720	extracellular matrix production	1690:1720	Moreover, PNH exhibited excellent biocompatibility and low cytotoxicity, and provided a natural three-dimensional biomimetic microenvironment to efficiently promote chondrocyte survival and proliferation, extracellular matrix production, and cartilage regeneration.
33545814	7	43	from	groups	1151:1156	arg1	surfaces					1166:1173	LDTM surfaces	1161:1173	LDTM surfaces	1161:1173	Moreover, the photo-generated aldehyde groups in PNH could rapidly react with inherent amino groups on LDTM surfaces to form imine bonds, which efficiently immobilized the cell-PNH composite to the surfaces of LDTM and/or maintained the composite in the LDTM micropores.
33545814	10	44	theme	matrix	2021:2026	arg1	deposition					2028:2037	cartilage-specific extracellular matrix deposition	1988:2037	cartilage-specific extracellular matrix deposition	1988:2037	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	10	45	theme	cell-seeding	1789:1800	arg1	concentration					1802:1814	a relatively low cell-seeding concentration	1772:1814	a relatively low cell-seeding concentration	1772:1814	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	10	46	theme	tubular	1829:1835	arg1	cartilage					1837:1845	homogeneous tubular cartilage	1817:1845	homogeneous tubular cartilage	1817:1845	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	1	47	theme	trachea	165:171	arg1	defects					173:179	long segmental trachea defects	150:179	long segmental trachea defects	150:179	Repair of long segmental trachea defects is always a great challenge in the clinic.
33545814	4	48	theme	cell	615:618	arg1	adhesion					620:627	the very low cell adhesion	602:627	the very low cell adhesion of LDTM	602:635	However, as a result of the very low cell adhesion of LDTM, an overly high concentration of seeding cell is required, which greatly restricts its clinical translation.
33545814	10	49	theme	cartilage-specific	1988:2005	arg1	deposition					2028:2037	cartilage-specific extracellular matrix deposition	1988:2037	cartilage-specific extracellular matrix deposition	1988:2037	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	9	50	theme	cartilage	1727:1735	arg1	regeneration					1737:1748	cartilage regeneration	1727:1748	cartilage regeneration	1727:1748	Moreover, PNH exhibited excellent biocompatibility and low cytotoxicity, and provided a natural three-dimensional biomimetic microenvironment to efficiently promote chondrocyte survival and proliferation, extracellular matrix production, and cartilage regeneration.
33545814	7	51	theme	amino	1145:1149	arg1	groups					1151:1156	inherent amino groups	1136:1156	inherent amino groups on LDTM surfaces	1136:1173	Moreover, the photo-generated aldehyde groups in PNH could rapidly react with inherent amino groups on LDTM surfaces to form imine bonds, which efficiently immobilized the cell-PNH composite to the surfaces of LDTM and/or maintained the composite in the LDTM micropores.
33545814	3	52	theme	cartilage	511:519	arg1	regeneration					521:532	satisfactory cartilage regeneration	498:532	satisfactory cartilage regeneration	498:532	Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for tissue-engineered trachea regeneration.
33545814	11	53	theme	satisfactory	2160:2171	arg1	trachea					2173:2179	a satisfactory trachea	2158:2179	a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects	2158:2266	Our findings establish a versatile and efficient cell-seeding strategy for regeneration of various tissue and provide a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects.
33545814	1	54	theme	defects	173:179	arg1	challenge					199:207	a great challenge	191:207	a great challenge in the clinic	191:221	Repair of long segmental trachea defects is always a great challenge in the clinic.
33545814	1	54	theme	defects	173:179	arg1	Repair					140:145	Repair	140:145	Repair of long segmental trachea defects	140:179	Repair of long segmental trachea defects is always a great challenge in the clinic.
33545814	3	55	theme	trachea	556:562	arg1	regeneration					564:575	tissue-engineered trachea regeneration	538:575	tissue-engineered trachea regeneration	538:575	Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for tissue-engineered trachea regeneration.
33545814	5	56	theme	PNH	856:858	arg1	carrier					861:867	a photocrosslinked natural hydrogel (PNH) carrier	819:867	a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration	819:948	To address this issue, the current study proposed a novel strategy using a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration.
33545814	11	57	theme	various	2131:2137	arg1	tissue					2139:2144	various tissue	2131:2144	various tissue	2131:2144	Our findings establish a versatile and efficient cell-seeding strategy for regeneration of various tissue and provide a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects.
33545814	1	58	theme	great	193:197	arg1	challenge					199:207	a great challenge	191:207	a great challenge in the clinic	191:221	Repair of long segmental trachea defects is always a great challenge in the clinic.
33545814	1	58	theme	great	193:197	arg1	Repair					140:145	Repair	140:145	Repair of long segmental trachea defects	140:179	Repair of long segmental trachea defects is always a great challenge in the clinic.
33545814	7	59	from	composite	1295:1303	arg1	micropores					1317:1326	the LDTM micropores	1308:1326	the LDTM micropores	1308:1326	Moreover, the photo-generated aldehyde groups in PNH could rapidly react with inherent amino groups on LDTM surfaces to form imine bonds, which efficiently immobilized the cell-PNH composite to the surfaces of LDTM and/or maintained the composite in the LDTM micropores.
33545814	4	60	theme	seeding	670:676	arg1	cell					678:681	seeding cell	670:681	seeding cell	670:681	However, as a result of the very low cell adhesion of LDTM, an overly high concentration of seeding cell is required, which greatly restricts its clinical translation.
33545814	10	61	theme	tracheal	1893:1900	arg1	shape					1902:1906	an accurate tracheal shape	1881:1906	an accurate tracheal shape	1881:1906	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	5	62	theme	photocrosslinked	821:836	arg1	carrier					861:867	a photocrosslinked natural hydrogel (PNH) carrier	819:867	a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration	819:948	To address this issue, the current study proposed a novel strategy using a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration.
33545814	11	63	theme	long	2236:2239	arg1	defects					2260:2266	long segmental tracheal defects	2236:2266	long segmental tracheal defects	2236:2266	Our findings establish a versatile and efficient cell-seeding strategy for regeneration of various tissue and provide a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects.
33545814	7	64	theme	photo-generated	1072:1086	arg1	groups					1097:1102	the photo-generated aldehyde groups	1068:1102	the photo-generated aldehyde groups in PNH	1068:1109	Moreover, the photo-generated aldehyde groups in PNH could rapidly react with inherent amino groups on LDTM surfaces to form imine bonds, which efficiently immobilized the cell-PNH composite to the surfaces of LDTM and/or maintained the composite in the LDTM micropores.
33545814	5	65	theme	hydrogel	846:853	arg1	carrier					861:867	a photocrosslinked natural hydrogel (PNH) carrier	819:867	a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration	819:948	To address this issue, the current study proposed a novel strategy using a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration.
33545814	10	66	theme	mechanical	1920:1929	arg1	strength					1931:1938	sufficient mechanical strength	1909:1938	sufficient mechanical strength	1909:1938	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	9	67	theme	low	1540:1542	arg1	cytotoxicity					1544:1555	low cytotoxicity	1540:1555	low cytotoxicity	1540:1555	Moreover, PNH exhibited excellent biocompatibility and low cytotoxicity, and provided a natural three-dimensional biomimetic microenvironment to efficiently promote chondrocyte survival and proliferation, extracellular matrix production, and cartilage regeneration.
33545814	11	68	dep	trachea	2173:2179	arg1	substitute					2181:2190	substitute	2181:2190	substitute for repair and functional reconstruction of long segmental tracheal defects	2181:2266	Our findings establish a versatile and efficient cell-seeding strategy for regeneration of various tissue and provide a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects.
33545814	10	69	theme	typical	1958:1964	arg1	structure					1973:1981	typical lacuna structure	1958:1981	typical lacuna structure	1958:1981	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	5	70	theme	tracheal	918:925	arg1	regeneration					937:948	tracheal cartilage regeneration	918:948	tracheal cartilage regeneration	918:948	To address this issue, the current study proposed a novel strategy using a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration.
33545814	11	71	theme	tracheal	2251:2258	arg1	defects					2260:2266	long segmental tracheal defects	2236:2266	long segmental tracheal defects	2236:2266	Our findings establish a versatile and efficient cell-seeding strategy for regeneration of various tissue and provide a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects.
33545814	3	72	theme	tubular	480:486	arg1	shape					488:492	tubular shape	480:492	tubular shape	480:492	Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for tissue-engineered trachea regeneration.
33545814	1	73	from	challenge	199:207	arg1	clinic					216:221	the clinic	212:221	the clinic	212:221	Repair of long segmental trachea defects is always a great challenge in the clinic.
33545814	1	74	theme	segmental	155:163	arg1	defects					173:179	long segmental trachea defects	150:179	long segmental trachea defects	150:179	Repair of long segmental trachea defects is always a great challenge in the clinic.
33545814	3	75	theme	micropore	380:388	arg1	LDTM					401:404	LDTM	401:404	LDTM	401:404	Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for tissue-engineered trachea regeneration.
33545814	3	75	theme	micropore	380:388	arg1	technique					390:398	laser micropore technique	374:398	laser micropore technique (LDTM)	374:405	Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for tissue-engineered trachea regeneration.
33545814	2	76	with	trachea	279:285	arg1	function					314:321	biological function	303:321	biological function	303:321	The key to solving this problem is to develop an ideal trachea substitute with biological function.
33545814	7	77	theme	cell-PNH	1230:1237	arg1	composite					1239:1247	the cell-PNH composite	1226:1247	the cell-PNH composite	1226:1247	Moreover, the photo-generated aldehyde groups in PNH could rapidly react with inherent amino groups on LDTM surfaces to form imine bonds, which efficiently immobilized the cell-PNH composite to the surfaces of LDTM and/or maintained the composite in the LDTM micropores.
33545814	5	78	theme	retention	885:893	arg1	efficiency					895:904	cell retention efficiency	880:904	cell retention efficiency	880:904	To address this issue, the current study proposed a novel strategy using a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration.
33545814	6	79	theme	phase	1016:1020	arg1	conversion					1022:1031	a rapid liquid-solid phase conversion	995:1031	a rapid liquid-solid phase conversion	995:1031	Our results demonstrated that PNH underwent a rapid liquid-solid phase conversion under ultraviolet light.
33545814	0	80	theme	decellularized	109:122	arg1	matrix					132:137	decellularized trachea matrix	109:137	decellularized trachea matrix	109:137	Photocrosslinked natural hydrogel composed of hyaluronic acid and gelatin enhances cartilage regeneration of decellularized trachea matrix.
33545814	5	81	link	photocrosslinked	821:836	arg1	carrier					861:867	a photocrosslinked natural hydrogel (PNH) carrier	819:867	a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration	819:948	To address this issue, the current study proposed a novel strategy using a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration.
33545814	9	82	theme	biomimetic	1599:1608	arg1	microenvironment					1610:1625	a natural three-dimensional biomimetic microenvironment	1571:1625	a natural three-dimensional biomimetic microenvironment to efficiently promote chondrocyte survival and proliferation, extracellular matrix production, and cartilage regeneration	1571:1748	Moreover, PNH exhibited excellent biocompatibility and low cytotoxicity, and provided a natural three-dimensional biomimetic microenvironment to efficiently promote chondrocyte survival and proliferation, extracellular matrix production, and cartilage regeneration.
33545814	6	83	theme	rapid	997:1001	arg1	conversion					1022:1031	a rapid liquid-solid phase conversion	995:1031	a rapid liquid-solid phase conversion	995:1031	Our results demonstrated that PNH underwent a rapid liquid-solid phase conversion under ultraviolet light.
33545814	10	84	theme	low	1785:1787	arg1	concentration					1802:1814	a relatively low cell-seeding concentration	1772:1814	a relatively low cell-seeding concentration	1772:1814	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	0	85	theme	matrix	132:137	arg1	regeneration					93:104	cartilage regeneration	83:104	cartilage regeneration of decellularized trachea matrix	83:137	Photocrosslinked natural hydrogel composed of hyaluronic acid and gelatin enhances cartilage regeneration of decellularized trachea matrix.
33545814	9	86	theme	excellent	1509:1517	arg1	biocompatibility					1519:1534	excellent biocompatibility	1509:1534	excellent biocompatibility	1509:1534	Moreover, PNH exhibited excellent biocompatibility and low cytotoxicity, and provided a natural three-dimensional biomimetic microenvironment to efficiently promote chondrocyte survival and proliferation, extracellular matrix production, and cartilage regeneration.
33545814	3	87	theme	trachea	350:356	arg1	matrix					358:363	a decellularized trachea matrix	333:363	a decellularized trachea matrix based on laser micropore technique (LDTM)	333:405	Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for tissue-engineered trachea regeneration.
33545814	5	88	theme	novel	798:802	arg1	strategy					804:811	a novel strategy	796:811	a novel strategy using a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration	796:948	To address this issue, the current study proposed a novel strategy using a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration.
33545814	3	89	theme	laser	374:378	arg1	LDTM					401:404	LDTM	401:404	LDTM	401:404	Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for tissue-engineered trachea regeneration.
33545814	3	89	theme	laser	374:378	arg1	technique					390:398	laser micropore technique	374:398	laser micropore technique (LDTM)	374:405	Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for tissue-engineered trachea regeneration.
33545814	8	90	theme	stable	1409:1414	arg1	retention					1421:1429	stable cell retention	1409:1429	stable cell retention	1409:1429	Therefore, PNH significantly enhanced cell-seeding efficiency and achieved both stable cell retention and homogenous cell distribution throughout the LDTM.
33545814	11	91	theme	efficient	2079:2087	arg1	strategy					2102:2109	a versatile and efficient cell-seeding strategy	2063:2109	a versatile and efficient cell-seeding strategy for regeneration of various tissue	2063:2144	Our findings establish a versatile and efficient cell-seeding strategy for regeneration of various tissue and provide a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects.
33545814	5	92	theme	current	773:779	arg1	study					781:785	the current study	769:785	the current study	769:785	To address this issue, the current study proposed a novel strategy using a photocrosslinked natural hydrogel (PNH) carrier to enhance cell retention efficiency and improve tracheal cartilage regeneration.
33545814	11	93	theme	versatile	2065:2073	arg1	strategy					2102:2109	a versatile and efficient cell-seeding strategy	2063:2109	a versatile and efficient cell-seeding strategy for regeneration of various tissue	2063:2144	Our findings establish a versatile and efficient cell-seeding strategy for regeneration of various tissue and provide a satisfactory trachea substitute for repair and functional reconstruction of long segmental tracheal defects.
33545814	9	94	theme	extracellular	1690:1702	arg1	production					1711:1720	extracellular matrix production	1690:1720	extracellular matrix production	1690:1720	Moreover, PNH exhibited excellent biocompatibility and low cytotoxicity, and provided a natural three-dimensional biomimetic microenvironment to efficiently promote chondrocyte survival and proliferation, extracellular matrix production, and cartilage regeneration.
33545814	8	95	theme	homogenous	1435:1444	arg1	distribution					1451:1462	homogenous cell distribution	1435:1462	homogenous cell distribution	1435:1462	Therefore, PNH significantly enhanced cell-seeding efficiency and achieved both stable cell retention and homogenous cell distribution throughout the LDTM.
33545814	3	96	theme	satisfactory	498:509	arg1	regeneration					521:532	satisfactory cartilage regeneration	498:532	satisfactory cartilage regeneration	498:532	Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for tissue-engineered trachea regeneration.
33545814	4	97	theme	adhesion	620:627	arg1	concentration					653:665	an overly high concentration	638:665	an overly high concentration of seeding cell	638:681	However, as a result of the very low cell adhesion of LDTM, an overly high concentration of seeding cell is required, which greatly restricts its clinical translation.
33545814	4	97	theme	adhesion	620:627	arg1	result					592:597	a result	590:597	a result of the very low cell adhesion of LDTM	590:635	However, as a result of the very low cell adhesion of LDTM, an overly high concentration of seeding cell is required, which greatly restricts its clinical translation.
33545814	10	98	theme	extracellular	2007:2019	arg1	deposition					2028:2037	cartilage-specific extracellular matrix deposition	1988:2037	cartilage-specific extracellular matrix deposition	1988:2037	Most importantly, at a relatively low cell-seeding concentration, homogeneous tubular cartilage was successfully regenerated with an accurate tracheal shape, sufficient mechanical strength, good elasticity, typical lacuna structure, and cartilage-specific extracellular matrix deposition.
33545814	3	99	theme	tissue-engineered	538:554	arg1	regeneration					564:575	tissue-engineered trachea regeneration	538:575	tissue-engineered trachea regeneration	538:575	Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for tissue-engineered trachea regeneration.
33545814	7	100	theme	LDTM	1268:1271	arg1	surfaces					1256:1263	the surfaces	1252:1263	the surfaces of LDTM	1252:1271	Moreover, the photo-generated aldehyde groups in PNH could rapidly react with inherent amino groups on LDTM surfaces to form imine bonds, which efficiently immobilized the cell-PNH composite to the surfaces of LDTM and/or maintained the composite in the LDTM micropores.
33545814	4	101	theme	LDTM	632:635	arg1	adhesion					620:627	the very low cell adhesion	602:627	the very low cell adhesion of LDTM	602:635	However, as a result of the very low cell adhesion of LDTM, an overly high concentration of seeding cell is required, which greatly restricts its clinical translation.
33545814	0	102	theme	natural	17:23	arg1	hydrogel					25:32	Photocrosslinked natural hydrogel	0:32	Photocrosslinked natural hydrogel composed of hyaluronic acid and gelatin	0:72	Photocrosslinked natural hydrogel composed of hyaluronic acid and gelatin enhances cartilage regeneration of decellularized trachea matrix.
35229779	6	0	dep	AIM	579:581	arg1	study					587:591	The study	583:591	AIM The study	579:591	AIM The study estimated the differences in IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight.
35229779	15	1	dep	CONCLUSION	1503:1512	arg1	increased					1556:1564	increased	1556:1564	increased with 5% chitosan compared with other percentage of chitosan	1556:1624	CONCLUSION The impact strength of denture base resin increased with 5% chitosan compared with other percentage of chitosan.
35229779	6	2	from	differences	607:617	arg1	strength					634:641	IZOD impact strength	622:641	IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight	622:721	AIM The study estimated the differences in IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight.
35229779	15	3	theme	impact	1518:1523	arg1	strength					1525:1532	The impact strength	1514:1532	The impact strength of denture base resin	1514:1554	CONCLUSION The impact strength of denture base resin increased with 5% chitosan compared with other percentage of chitosan.
35229779	5	4	theme	chitosan-reinforced	538:556	arg1	resins					571:576	chitosan-reinforced denture base resins	538:576	chitosan-reinforced denture base resins	538:576	This study estimates the differences in impact strength of material for different concentrations of chitosan-reinforced denture base resins.
35229779	2	5	theme	constituents	278:289	arg1	addition					262:269	the addition	258:269	the addition of new constituents	258:289	Efforts are made to increase the applications with the addition of new constituents.
35229779	5	6	theme	base	566:569	arg1	resins					571:576	chitosan-reinforced denture base resins	538:576	chitosan-reinforced denture base resins	538:576	This study estimates the differences in impact strength of material for different concentrations of chitosan-reinforced denture base resins.
35229779	1	7	theme	base	192:195	arg1	material					197:204	an universally acceptable denture base material	158:204	an universally acceptable denture base material	158:204	BACKGROUND Poly-methyl methacrylate (PMMA) is an universally acceptable denture base material.
35229779	1	7	theme	base	192:195	arg1	methacrylate					135:146	BACKGROUND Poly-methyl methacrylate	112:146	BACKGROUND Poly-methyl methacrylate (PMMA)	112:153	BACKGROUND Poly-methyl methacrylate (PMMA) is an universally acceptable denture base material.
35229779	6	8	theme	resin	659:663	arg1	strength					634:641	IZOD impact strength	622:641	IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight	622:721	AIM The study estimated the differences in IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight.
35229779	6	9	theme	denture	646:652	arg1	resin					659:663	denture base resin	646:663	denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight	646:721	AIM The study estimated the differences in IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight.
35229779	11	10	theme	heat	1033:1036	arg1	cycle					1053:1057	conventional heat polymerization cycle	1020:1057	conventional heat polymerization cycle	1020:1057	The samples were processed by conventional heat polymerization cycle and tested in IZOD impact testing machine.
35229779	13	11	dep	RESULTS	1178:1184	arg1	high					1215:1218	high	1215:1218	high	1215:1218	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	13	11	dep	RESULTS	1178:1184	arg1	strength					1202:1209	The mean impact strength	1186:1209	The mean impact strength	1186:1209	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	14	12	theme	=	1474:1474	arg1	.005					1488:1491	Chi-square = 12.843, P = .005	1463:1491	.005	1488:1491	Statistically significant differences between the test groups was determined by Kruskal-Wallis and post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3).
35229779	6	13	theme	IZOD	622:625	arg1	strength					634:641	IZOD impact strength	622:641	IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight	622:721	AIM The study estimated the differences in IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight.
35229779	16	14	theme	significant	1642:1652	arg1	relationship					1654:1665	No statistical significant relationship	1627:1665	No statistical significant relationship	1627:1665	No statistical significant relationship was observed between the groups.
35229779	3	15	theme	established	305:315	arg1	properties					328:337	established antifungal properties	305:337	established antifungal properties	305:337	Chitosan has established antifungal properties.
35229779	10	16	theme	%	977:977	arg1	reinforcement					946:958	chitosan reinforcement	937:958	chitosan reinforcement of 5%, 10% and 15% by weight	937:987	ACh5, ACh10 and ACh15 had chitosan reinforcement of 5%, 10% and 15% by weight.
35229779	14	17	theme	Bonferroni	1446:1455	arg1	test					1457:1460	post hoc Bonferroni test	1437:1460	post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3)	1437:1500	Statistically significant differences between the test groups was determined by Kruskal-Wallis and post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3).
35229779	15	18	theme	%	1572:1572	arg1	chitosan					1574:1581	5% chitosan	1571:1581	5% chitosan	1571:1581	CONCLUSION The impact strength of denture base resin increased with 5% chitosan compared with other percentage of chitosan.
35229779	14	19	theme	post	1437:1440	arg1	test					1457:1460	post hoc Bonferroni test	1437:1460	post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3)	1437:1500	Statistically significant differences between the test groups was determined by Kruskal-Wallis and post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3).
35229779	13	20	theme	±	1234:1234	arg1	kJ/m2					1241:1245	4.25 ± 1.05 kJ/m2	1229:1245	4.25 ± 1.05 kJ/m2	1229:1245	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	13	20	theme	±	1234:1234	arg1	ACh5					1223:1226	ACh5	1223:1226	ACh5 (4.25 ± 1.05 kJ/m2)	1223:1246	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	0	21	theme	denture	91:97	arg1	resins					104:109	chitosan-reinforced denture base resins	71:109	chitosan-reinforced denture base resins	71:109	Estimation of IZOD impact strength between different concentrations of chitosan-reinforced denture base resins.
35229779	1	22	theme	acceptable	173:182	arg1	material					197:204	an universally acceptable denture base material	158:204	an universally acceptable denture base material	158:204	BACKGROUND Poly-methyl methacrylate (PMMA) is an universally acceptable denture base material.
35229779	1	22	theme	acceptable	173:182	arg1	methacrylate					135:146	BACKGROUND Poly-methyl methacrylate	112:146	BACKGROUND Poly-methyl methacrylate (PMMA)	112:153	BACKGROUND Poly-methyl methacrylate (PMMA) is an universally acceptable denture base material.
35229779	15	23	theme	resin	1550:1554	arg1	strength					1525:1532	The impact strength	1514:1532	The impact strength of denture base resin	1514:1554	CONCLUSION The impact strength of denture base resin increased with 5% chitosan compared with other percentage of chitosan.
35229779	0	24	theme	resins	104:109	arg1	concentrations					53:66	different concentrations	43:66	different concentrations of chitosan-reinforced denture base resins	43:109	Estimation of IZOD impact strength between different concentrations of chitosan-reinforced denture base resins.
35229779	14	25	theme	P	1484:1484	arg1	.005					1488:1491	Chi-square = 12.843, P = .005	1463:1491	.005	1488:1491	Statistically significant differences between the test groups was determined by Kruskal-Wallis and post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3).
35229779	0	26	theme	IZOD	14:17	arg1	strength					26:33	IZOD impact strength	14:33	IZOD impact strength	14:33	Estimation of IZOD impact strength between different concentrations of chitosan-reinforced denture base resins.
35229779	7	27	theme	ISO	798:800	arg1	regulations					806:816	ISO 180 regulations	798:816	ISO 180 regulations	798:816	MATERIALS AND METHODS The acrylic samples were fabricated in according to ISO 180 regulations.
35229779	1	28	theme	Poly-methyl	123:133	arg1	PMMA					149:152	PMMA	149:152	PMMA	149:152	BACKGROUND Poly-methyl methacrylate (PMMA) is an universally acceptable denture base material.
35229779	1	28	theme	Poly-methyl	123:133	arg1	material					197:204	an universally acceptable denture base material	158:204	an universally acceptable denture base material	158:204	BACKGROUND Poly-methyl methacrylate (PMMA) is an universally acceptable denture base material.
35229779	1	28	theme	Poly-methyl	123:133	arg1	methacrylate					135:146	BACKGROUND Poly-methyl methacrylate	112:146	BACKGROUND Poly-methyl methacrylate (PMMA)	112:153	BACKGROUND Poly-methyl methacrylate (PMMA) is an universally acceptable denture base material.
35229779	3	29	contain	has	301:303	arg1	Chitosan					292:299	Chitosan	292:299	Chitosan	292:299	Chitosan has established antifungal properties.
35229779	3	29	contain	has	301:303	arg2	properties					328:337	established antifungal properties	305:337	established antifungal properties	305:337	Chitosan has established antifungal properties.
35229779	15	30	theme	other	1597:1601	arg1	percentage					1603:1612	other percentage	1597:1612	other percentage of chitosan	1597:1624	CONCLUSION The impact strength of denture base resin increased with 5% chitosan compared with other percentage of chitosan.
35229779	0	31	theme	strength	26:33	arg1	Estimation					0:9	Estimation	0:9	Estimation of IZOD impact strength between different concentrations of chitosan-reinforced denture base resins.	0:110	Estimation of IZOD impact strength between different concentrations of chitosan-reinforced denture base resins.
35229779	4	32	theme	base	386:389	arg1	composite					391:399	Chitosan-denture base composite	369:399	Chitosan-denture base composite	369:399	The mechanical properties of Chitosan-denture base composite is less evaluated in the literature.
35229779	0	33	theme	different	43:51	arg1	concentrations					53:66	different concentrations	43:66	different concentrations of chitosan-reinforced denture base resins	43:109	Estimation of IZOD impact strength between different concentrations of chitosan-reinforced denture base resins.
35229779	16	34	theme	statistical	1630:1640	arg1	relationship					1654:1665	No statistical significant relationship	1627:1665	No statistical significant relationship	1627:1665	No statistical significant relationship was observed between the groups.
35229779	11	35	theme	testing	1085:1091	arg1	machine					1093:1099	IZOD impact testing machine	1073:1099	IZOD impact testing machine	1073:1099	The samples were processed by conventional heat polymerization cycle and tested in IZOD impact testing machine.
35229779	4	36	theme	mechanical	344:353	arg1	properties					355:364	The mechanical properties	340:364	The mechanical properties of Chitosan-denture base composite	340:399	The mechanical properties of Chitosan-denture base composite is less evaluated in the literature.
35229779	14	37	theme	significant	1352:1362	arg1	differences					1364:1374	Statistically significant differences	1338:1374	Statistically significant differences between the test groups	1338:1398	Statistically significant differences between the test groups was determined by Kruskal-Wallis and post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3).
35229779	5	38	theme	material	497:504	arg1	strength					485:492	impact strength	478:492	impact strength of material for different concentrations of chitosan-reinforced denture base resins	478:576	This study estimates the differences in impact strength of material for different concentrations of chitosan-reinforced denture base resins.
35229779	11	39	theme	IZOD	1073:1076	arg1	machine					1093:1099	IZOD impact testing machine	1073:1099	IZOD impact testing machine	1073:1099	The samples were processed by conventional heat polymerization cycle and tested in IZOD impact testing machine.
35229779	12	40	theme	Kruskal-Wallis	1157:1170	arg1	test					1172:1175	Kruskal-Wallis test	1157:1175	Kruskal-Wallis test	1157:1175	The data were recorded and statistically analyzed with Kruskal-Wallis test.
35229779	13	41	theme	mean	1190:1193	arg1	high					1215:1218	high	1215:1218	high	1215:1218	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	13	41	theme	mean	1190:1193	arg1	strength					1202:1209	The mean impact strength	1186:1209	The mean impact strength	1186:1209	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	15	42	theme	denture	1537:1543	arg1	resin					1550:1554	denture base resin	1537:1554	denture base resin	1537:1554	CONCLUSION The impact strength of denture base resin increased with 5% chitosan compared with other percentage of chitosan.
35229779	5	43	theme	denture	558:564	arg1	resins					571:576	chitosan-reinforced denture base resins	538:576	chitosan-reinforced denture base resins	538:576	This study estimates the differences in impact strength of material for different concentrations of chitosan-reinforced denture base resins.
35229779	1	44	theme	denture	184:190	arg1	material					197:204	an universally acceptable denture base material	158:204	an universally acceptable denture base material	158:204	BACKGROUND Poly-methyl methacrylate (PMMA) is an universally acceptable denture base material.
35229779	1	44	theme	denture	184:190	arg1	methacrylate					135:146	BACKGROUND Poly-methyl methacrylate	112:146	BACKGROUND Poly-methyl methacrylate (PMMA)	112:153	BACKGROUND Poly-methyl methacrylate (PMMA) is an universally acceptable denture base material.
35229779	14	45	dep	=	1497:1497	arg1	.005					1488:1491	Chi-square = 12.843, P = .005	1463:1491	.005	1488:1491	Statistically significant differences between the test groups was determined by Kruskal-Wallis and post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3).
35229779	5	46	theme	resins	571:576	arg1	concentrations					520:533	different concentrations	510:533	different concentrations of chitosan-reinforced denture base resins	510:576	This study estimates the differences in impact strength of material for different concentrations of chitosan-reinforced denture base resins.
35229779	8	47	contain	had	829:831	arg2	n					851:851	n = 10	851:856	n = 10	851:856	The study had four test groups (n = 10).
35229779	8	47	contain	had	829:831	arg2	groups					843:848	four test groups	833:848	four test groups (n = 10)	833:857	The study had four test groups (n = 10).
35229779	8	47	contain	had	829:831	arg1	study					823:827	The study	819:827	The study	819:827	The study had four test groups (n = 10).
35229779	10	48	contain	had	933:935	arg1	ACh15					927:931	ACh15	927:931	ACh15	927:931	ACh5, ACh10 and ACh15 had chitosan reinforcement of 5%, 10% and 15% by weight.
35229779	10	48	contain	had	933:935	arg1	ACh5					911:914	ACh5	911:914	ACh5	911:914	ACh5, ACh10 and ACh15 had chitosan reinforcement of 5%, 10% and 15% by weight.
35229779	10	48	contain	had	933:935	arg2	reinforcement					946:958	chitosan reinforcement	937:958	chitosan reinforcement of 5%, 10% and 15% by weight	937:987	ACh5, ACh10 and ACh15 had chitosan reinforcement of 5%, 10% and 15% by weight.
35229779	10	48	contain	had	933:935	arg1	ACh10					917:921	ACh10	917:921	ACh10	917:921	ACh5, ACh10 and ACh15 had chitosan reinforcement of 5%, 10% and 15% by weight.
35229779	5	49	theme	different	510:518	arg1	concentrations					520:533	different concentrations	510:533	different concentrations of chitosan-reinforced denture base resins	510:576	This study estimates the differences in impact strength of material for different concentrations of chitosan-reinforced denture base resins.
35229779	11	50	theme	conventional	1020:1031	arg1	cycle					1053:1057	conventional heat polymerization cycle	1020:1057	conventional heat polymerization cycle	1020:1057	The samples were processed by conventional heat polymerization cycle and tested in IZOD impact testing machine.
35229779	10	51	theme	%	969:969	arg1	reinforcement					946:958	chitosan reinforcement	937:958	chitosan reinforcement of 5%, 10% and 15% by weight	937:987	ACh5, ACh10 and ACh15 had chitosan reinforcement of 5%, 10% and 15% by weight.
35229779	6	52	theme	base	654:657	arg1	resin					659:663	denture base resin	646:663	denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight	646:721	AIM The study estimated the differences in IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight.
35229779	14	53	theme	12.843	1476:1481	arg1	.005					1488:1491	Chi-square = 12.843, P = .005	1463:1491	.005	1488:1491	Statistically significant differences between the test groups was determined by Kruskal-Wallis and post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3).
35229779	6	54	theme	impact	627:632	arg1	strength					634:641	IZOD impact strength	622:641	IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight	622:721	AIM The study estimated the differences in IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight.
35229779	13	55	theme	±	1271:1271	arg1	kJ/m2					1278:1282	2.88 ± 0.60 kJ/m2	1266:1282	2.88 ± 0.60 kJ/m2	1266:1282	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	13	55	theme	±	1271:1271	arg1	ACh0					1260:1263	ACh0	1260:1263	ACh0 (2.88 ± 0.60 kJ/m2)	1260:1283	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	14	56	theme	Chi-square	1463:1472	arg1	.005					1488:1491	Chi-square = 12.843, P = .005	1463:1491	.005	1488:1491	Statistically significant differences between the test groups was determined by Kruskal-Wallis and post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3).
35229779	10	57	theme	%	964:964	arg1	reinforcement					946:958	chitosan reinforcement	937:958	chitosan reinforcement of 5%, 10% and 15% by weight	937:987	ACh5, ACh10 and ACh15 had chitosan reinforcement of 5%, 10% and 15% by weight.
35229779	2	58	theme	new	274:276	arg1	constituents					278:289	new constituents	274:289	new constituents	274:289	Efforts are made to increase the applications with the addition of new constituents.
35229779	3	59	theme	antifungal	317:326	arg1	properties					328:337	established antifungal properties	305:337	established antifungal properties	305:337	Chitosan has established antifungal properties.
35229779	15	60	theme	5	1571:1571	arg1	%					1572:1572	%	1572:1572	%	1572:1572	CONCLUSION The impact strength of denture base resin increased with 5% chitosan compared with other percentage of chitosan.
35229779	0	61	theme	chitosan-reinforced	71:89	arg1	resins					104:109	chitosan-reinforced denture base resins	71:109	chitosan-reinforced denture base resins	71:109	Estimation of IZOD impact strength between different concentrations of chitosan-reinforced denture base resins.
35229779	13	62	from	high	1215:1218	arg1	kJ/m2					1241:1245	4.25 ± 1.05 kJ/m2	1229:1245	4.25 ± 1.05 kJ/m2	1229:1245	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	13	62	from	high	1215:1218	arg1	ACh5					1223:1226	ACh5	1223:1226	ACh5 (4.25 ± 1.05 kJ/m2)	1223:1246	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	14	63	theme	hoc	1442:1444	arg1	test					1457:1460	post hoc Bonferroni test	1437:1460	post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3)	1437:1500	Statistically significant differences between the test groups was determined by Kruskal-Wallis and post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3).
35229779	0	64	theme	base	99:102	arg1	resins					104:109	chitosan-reinforced denture base resins	71:109	chitosan-reinforced denture base resins	71:109	Estimation of IZOD impact strength between different concentrations of chitosan-reinforced denture base resins.
35229779	8	65	theme	test	838:841	arg1	groups					843:848	four test groups	833:848	four test groups (n = 10)	833:857	The study had four test groups (n = 10).
35229779	8	65	theme	test	838:841	arg1	n					851:851	n = 10	851:856	n = 10	851:856	The study had four test groups (n = 10).
35229779	15	66	theme	base	1545:1548	arg1	resin					1550:1554	denture base resin	1537:1554	denture base resin	1537:1554	CONCLUSION The impact strength of denture base resin increased with 5% chitosan compared with other percentage of chitosan.
35229779	5	67	from	differences	463:473	arg1	strength					485:492	impact strength	478:492	impact strength of material for different concentrations of chitosan-reinforced denture base resins	478:576	This study estimates the differences in impact strength of material for different concentrations of chitosan-reinforced denture base resins.
35229779	14	68	theme	=	1486:1486	arg1	.005					1488:1491	Chi-square = 12.843, P = .005	1463:1491	.005	1488:1491	Statistically significant differences between the test groups was determined by Kruskal-Wallis and post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3).
35229779	8	69	theme	=	853:853	arg1	groups					843:848	four test groups	833:848	four test groups (n = 10)	833:857	The study had four test groups (n = 10).
35229779	8	69	theme	=	853:853	arg1	n					851:851	n = 10	851:856	n = 10	851:856	The study had four test groups (n = 10).
35229779	13	70	from	ACh5	1223:1226	arg1	high					1215:1218	high	1215:1218	high	1215:1218	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	13	70	from	ACh5	1223:1226	arg1	strength					1202:1209	The mean impact strength	1186:1209	The mean impact strength	1186:1209	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	15	71	theme	chitosan	1617:1624	arg1	percentage					1603:1612	other percentage	1597:1612	other percentage of chitosan	1597:1624	CONCLUSION The impact strength of denture base resin increased with 5% chitosan compared with other percentage of chitosan.
35229779	14	72	theme	test	1388:1391	arg1	groups					1393:1398	the test groups	1384:1398	the test groups	1384:1398	Statistically significant differences between the test groups was determined by Kruskal-Wallis and post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3).
35229779	0	73	theme	impact	19:24	arg1	strength					26:33	IZOD impact strength	14:33	IZOD impact strength	14:33	Estimation of IZOD impact strength between different concentrations of chitosan-reinforced denture base resins.
35229779	1	74	theme	BACKGROUND	112:121	arg1	PMMA					149:152	PMMA	149:152	PMMA	149:152	BACKGROUND Poly-methyl methacrylate (PMMA) is an universally acceptable denture base material.
35229779	1	74	theme	BACKGROUND	112:121	arg1	material					197:204	an universally acceptable denture base material	158:204	an universally acceptable denture base material	158:204	BACKGROUND Poly-methyl methacrylate (PMMA) is an universally acceptable denture base material.
35229779	1	74	theme	BACKGROUND	112:121	arg1	methacrylate					135:146	BACKGROUND Poly-methyl methacrylate	112:146	BACKGROUND Poly-methyl methacrylate (PMMA)	112:153	BACKGROUND Poly-methyl methacrylate (PMMA) is an universally acceptable denture base material.
35229779	10	75	theme	chitosan	937:944	arg1	reinforcement					946:958	chitosan reinforcement	937:958	chitosan reinforcement of 5%, 10% and 15% by weight	937:987	ACh5, ACh10 and ACh15 had chitosan reinforcement of 5%, 10% and 15% by weight.
35229779	11	76	theme	polymerization	1038:1051	arg1	cycle					1053:1057	conventional heat polymerization cycle	1020:1057	conventional heat polymerization cycle	1020:1057	The samples were processed by conventional heat polymerization cycle and tested in IZOD impact testing machine.
35229779	4	77	theme	Chitosan-denture	369:384	arg1	composite					391:399	Chitosan-denture base composite	369:399	Chitosan-denture base composite	369:399	The mechanical properties of Chitosan-denture base composite is less evaluated in the literature.
35229779	13	78	theme	impact	1195:1200	arg1	high					1215:1218	high	1215:1218	high	1215:1218	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	13	78	theme	impact	1195:1200	arg1	strength					1202:1209	The mean impact strength	1186:1209	The mean impact strength	1186:1209	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	14	79	dep	test	1457:1460	arg1	=					1497:1497	=	1497:1497	=	1497:1497	Statistically significant differences between the test groups was determined by Kruskal-Wallis and post hoc Bonferroni test (Chi-square = 12.843, P = .005, df = 3).
35229779	5	80	theme	impact	478:483	arg1	strength					485:492	impact strength	478:492	impact strength of material for different concentrations of chitosan-reinforced denture base resins	478:576	This study estimates the differences in impact strength of material for different concentrations of chitosan-reinforced denture base resins.
35229779	7	81	dep	MATERIALS	724:732	arg1	samples					758:764	The acrylic samples	746:764	The acrylic samples	746:764	MATERIALS AND METHODS The acrylic samples were fabricated in according to ISO 180 regulations.
35229779	11	82	theme	impact	1078:1083	arg1	machine					1093:1099	IZOD impact testing machine	1073:1099	IZOD impact testing machine	1073:1099	The samples were processed by conventional heat polymerization cycle and tested in IZOD impact testing machine.
35229779	4	83	theme	composite	391:399	arg1	properties					355:364	The mechanical properties	340:364	The mechanical properties of Chitosan-denture base composite	340:399	The mechanical properties of Chitosan-denture base composite is less evaluated in the literature.
35229779	9	84	theme	control	873:879	arg1	group					881:885	the control group	869:885	the control group with no reinforcements	869:908	ACh0 was the control group with no reinforcements.
35229779	9	84	theme	control	873:879	arg1	ACh0					860:863	ACh0	860:863	ACh0	860:863	ACh0 was the control group with no reinforcements.
35229779	6	85	theme	chitosan	704:711	arg1	%					682:682	0%	681:682	0%	681:682	AIM The study estimated the differences in IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight.
35229779	6	85	theme	chitosan	704:711	arg1	%					686:686	5%	685:686	5%	685:686	AIM The study estimated the differences in IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight.
35229779	6	85	theme	chitosan	704:711	arg1	%					691:691	10%	689:691	10%	689:691	AIM The study estimated the differences in IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight.
35229779	6	85	theme	chitosan	704:711	arg1	%					699:699	15%	697:699	15%	697:699	AIM The study estimated the differences in IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight.
35229779	6	85	theme	chitosan	704:711	arg1	chitosan					704:711	chitosan	704:711	chitosan	704:711	AIM The study estimated the differences in IZOD impact strength of denture base resin reinforced with 0%, 5%, 10% and 15% of chitosan by weight.
35229779	9	86	with	group	881:885	arg1	reinforcements					895:908	no reinforcements	892:908	no reinforcements	892:908	ACh0 was the control group with no reinforcements.
35229779	13	87	theme	±	1298:1298	arg1	kJ/m2					1305:1309	3.63 ± 0.40 kJ/m2	1293:1309	3.63 ± 0.40 kJ/m2	1293:1309	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	13	87	theme	±	1298:1298	arg1	ACh10					1286:1290	ACh10	1286:1290	ACh10 (3.63 ± 0.40 kJ/m2)	1286:1310	RESULTS The mean impact strength was high in ACh5 (4.25 ± 1.05 kJ/m2) compared to ACh0 (2.88 ± 0.60 kJ/m2), ACh10 (3.63 ± 0.40 kJ/m2), ACh15 (3.38±0.60 KJ/m2).
35229779	7	88	theme	acrylic	750:756	arg1	samples					758:764	The acrylic samples	746:764	The acrylic samples	746:764	MATERIALS AND METHODS The acrylic samples were fabricated in according to ISO 180 regulations.
32720020	0	0	theme	novel	75:79	arg1	materials					86:94	novel wall materials	75:94	novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation	75:182	Gum arabic and collagen hydrolysate extracted from hide fleshing wastes as novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation.
32720020	4	1	theme	particle	871:878	arg1	size					880:883	particle size	871:883	particle size	871:883	The encapsulation yield and efficiency, functional group composition, particle size, morphology, and thermal stability of the obtained OOEO microcapsules were characterized.
32720020	5	2	theme	uniform	1117:1123	arg1	morphology					1125:1134	uniform morphology	1117:1134	uniform morphology	1117:1134	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	2	3	theme	fleshing	399:406	arg1	wastes					408:413	hide fleshing wastes	394:413	hide fleshing wastes of leather industry	394:433	Obtaining collagen hydrolysate (CH) from hide fleshing wastes of leather industry is an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries.
32720020	5	4	theme	low	1140:1142	arg1	activity					1150:1157	low water activity	1140:1157	low water activity	1140:1157	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	5	5	theme	functional	1087:1096	arg1	properties					1098:1107	good functional properties	1082:1107	good functional properties such as uniform morphology and low water activity	1082:1157	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	5	5	theme	functional	1087:1096	arg1	activity					1150:1157	low water activity	1140:1157	low water activity	1140:1157	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	5	5	theme	functional	1087:1096	arg1	morphology					1125:1134	uniform morphology	1117:1134	uniform morphology	1117:1134	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	4	6	theme	microcapsules	941:953	arg1	morphology					886:895	morphology	886:895	morphology	886:895	The encapsulation yield and efficiency, functional group composition, particle size, morphology, and thermal stability of the obtained OOEO microcapsules were characterized.
32720020	4	6	theme	microcapsules	941:953	arg1	composition					858:868	functional group composition	841:868	functional group composition	841:868	The encapsulation yield and efficiency, functional group composition, particle size, morphology, and thermal stability of the obtained OOEO microcapsules were characterized.
32720020	4	6	theme	microcapsules	941:953	arg1	yield					819:823	The encapsulation yield	801:823	The encapsulation yield	801:823	The encapsulation yield and efficiency, functional group composition, particle size, morphology, and thermal stability of the obtained OOEO microcapsules were characterized.
32720020	4	6	theme	microcapsules	941:953	arg1	efficiency					829:838	efficiency	829:838	efficiency	829:838	The encapsulation yield and efficiency, functional group composition, particle size, morphology, and thermal stability of the obtained OOEO microcapsules were characterized.
32720020	4	6	theme	microcapsules	941:953	arg1	size					880:883	particle size	871:883	particle size	871:883	The encapsulation yield and efficiency, functional group composition, particle size, morphology, and thermal stability of the obtained OOEO microcapsules were characterized.
32720020	4	6	theme	microcapsules	941:953	arg1	stability					910:918	thermal stability	902:918	thermal stability	902:918	The encapsulation yield and efficiency, functional group composition, particle size, morphology, and thermal stability of the obtained OOEO microcapsules were characterized.
32720020	3	7	theme	wall	692:695	arg1	materials					697:705	wall materials	692:705	wall materials	692:705	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	3	7	theme	wall	692:695	arg1	ratios					611:616	2:1, 1:1, and 1 2 ratios	593:616	2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste	593:677	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	9	8	theme	wall	1479:1482	arg1	material					1484:1491	an ideal wall material	1470:1491	an ideal wall material using GA and CH for microencapsulation of essential oils	1470:1548	These findings can be useful in designing an ideal wall material using GA and CH for microencapsulation of essential oils by the complex coacervation method.
32720020	0	9	theme	wall	81:84	arg1	materials					86:94	novel wall materials	75:94	novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation	75:182	Gum arabic and collagen hydrolysate extracted from hide fleshing wastes as novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation.
32720020	3	10	theme	onites	731:736	arg1	OOEO					756:759	OOEO	756:759	OOEO	756:759	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	3	10	theme	onites	731:736	arg1	oil					751:753	Origanum onites L. essential oil	722:753	Origanum onites L. essential oil (OOEO)	722:760	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	8	11	theme	FTIR	1316:1319	arg1	analysis					1321:1328	FTIR analysis	1316:1328	FTIR analysis	1316:1328	FTIR analysis was performed on obtained microcapsules, confirming the molecular interactions between GA and CH.
32720020	6	12	dep	GA	1201:1202	arg1	CH					1204:1205	CH	1204:1205	CH	1204:1205	The best mass ratio for the biopolymers (GA:CH) was 1:1.
32720020	3	13	theme	L.	738:739	arg1	OOEO					756:759	OOEO	756:759	OOEO	756:759	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	3	13	theme	L.	738:739	arg1	oil					751:753	Origanum onites L. essential oil	722:753	Origanum onites L. essential oil (OOEO)	722:760	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	4	14	theme	functional	841:850	arg1	composition					858:868	functional group composition	841:868	functional group composition	841:868	The encapsulation yield and efficiency, functional group composition, particle size, morphology, and thermal stability of the obtained OOEO microcapsules were characterized.
32720020	9	15	theme	essential	1535:1543	arg1	oils					1545:1548	essential oils	1535:1548	essential oils	1535:1548	These findings can be useful in designing an ideal wall material using GA and CH for microencapsulation of essential oils by the complex coacervation method.
32720020	2	16	theme	industry	426:433	arg1	wastes					408:413	hide fleshing wastes	394:413	hide fleshing wastes of leather industry	394:433	Obtaining collagen hydrolysate (CH) from hide fleshing wastes of leather industry is an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries.
32720020	4	17	theme	encapsulation	805:817	arg1	yield					819:823	The encapsulation yield	801:823	The encapsulation yield	801:823	The encapsulation yield and efficiency, functional group composition, particle size, morphology, and thermal stability of the obtained OOEO microcapsules were characterized.
32720020	2	18	dep	wastes	408:413	arg1	hide					394:397	hide	394:397	hide	394:397	Obtaining collagen hydrolysate (CH) from hide fleshing wastes of leather industry is an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries.
32720020	4	19	theme	obtained	927:934	arg1	microcapsules					941:953	the obtained OOEO microcapsules	923:953	the obtained OOEO microcapsules	923:953	The encapsulation yield and efficiency, functional group composition, particle size, morphology, and thermal stability of the obtained OOEO microcapsules were characterized.
32720020	5	20	theme	high	1030:1033	arg1	yield					1049:1053	high encapsulation yield	1030:1053	high encapsulation yield	1030:1053	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	3	21	theme	Origanum	722:729	arg1	OOEO					756:759	OOEO	756:759	OOEO	756:759	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	3	21	theme	Origanum	722:729	arg1	oil					751:753	Origanum onites L. essential oil	722:753	Origanum onites L. essential oil (OOEO)	722:760	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	7	22	theme	microcapsule	1272:1283	arg1	samples					1285:1291	OOEO microcapsule samples	1267:1291	OOEO microcapsule samples	1267:1291	Scanning electron microscopy analysis showed that OOEO microcapsule samples had a spherical shape.
32720020	9	23	theme	oils	1545:1548	arg1	microencapsulation					1513:1530	microencapsulation	1513:1530	microencapsulation of essential oils	1513:1548	These findings can be useful in designing an ideal wall material using GA and CH for microencapsulation of essential oils by the complex coacervation method.
32720020	6	24	theme	best	1164:1167	arg1	ratio					1174:1178	The best mass ratio	1160:1178	The best mass ratio for the biopolymers (GA:CH)	1160:1206	The best mass ratio for the biopolymers (GA:CH) was 1:1.
32720020	6	24	theme	best	1164:1167	arg1	1:1					1212:1214	1:1	1212:1214	1:1	1212:1214	The best mass ratio for the biopolymers (GA:CH) was 1:1.
32720020	1	25	theme	Renewable	185:193	arg1	materials					224:232	Renewable resource-based biodegradable materials	185:232	Renewable resource-based biodegradable materials	185:232	Renewable resource-based biodegradable materials attract more attention than petroleum-based biodegradable materials to support the sustainable development of ecology.
32720020	0	26	theme	Gum	0:2	arg1	arabic					4:9	Gum arabic	0:9	Gum arabic	0:9	Gum arabic and collagen hydrolysate extracted from hide fleshing wastes as novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation.
32720020	1	27	theme	sustainable	317:327	arg1	development					329:339	the sustainable development	313:339	the sustainable development of ecology	313:350	Renewable resource-based biodegradable materials attract more attention than petroleum-based biodegradable materials to support the sustainable development of ecology.
32720020	4	28	theme	group	852:856	arg1	composition					858:868	functional group composition	841:868	functional group composition	841:868	The encapsulation yield and efficiency, functional group composition, particle size, morphology, and thermal stability of the obtained OOEO microcapsules were characterized.
32720020	2	29	theme	collagen	363:370	arg1	CH					385:386	CH	385:386	CH	385:386	Obtaining collagen hydrolysate (CH) from hide fleshing wastes of leather industry is an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries.
32720020	2	29	theme	collagen	363:370	arg1	hydrolysate					372:382	collagen hydrolysate	363:382	collagen hydrolysate (CH)	363:387	Obtaining collagen hydrolysate (CH) from hide fleshing wastes of leather industry is an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries.
32720020	2	30	theme	leather	418:424	arg1	industry					426:433	leather industry	418:433	leather industry	418:433	Obtaining collagen hydrolysate (CH) from hide fleshing wastes of leather industry is an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries.
32720020	0	31	theme	collagen	15:22	arg1	hydrolysate					24:34	collagen hydrolysate	15:34	collagen hydrolysate	15:34	Gum arabic and collagen hydrolysate extracted from hide fleshing wastes as novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation.
32720020	3	32	theme	coacervation	780:791	arg1	method					793:798	the complex coacervation method	768:798	the complex coacervation method	768:798	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	0	33	theme	Origanum	122:129	arg1	oil					151:153	Origanum onites L. essential oil	122:153	Origanum onites L. essential oil through complex coacervation	122:182	Gum arabic and collagen hydrolysate extracted from hide fleshing wastes as novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation.
32720020	0	34	dep	wastes	65:70	arg1	hide					51:54	hide	51:54	hide	51:54	Gum arabic and collagen hydrolysate extracted from hide fleshing wastes as novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation.
32720020	8	35	theme	molecular	1386:1394	arg1	interactions					1396:1407	the molecular interactions	1382:1407	the molecular interactions between GA and CH	1382:1425	FTIR analysis was performed on obtained microcapsules, confirming the molecular interactions between GA and CH.
32720020	1	36	theme	biodegradable	210:222	arg1	materials					224:232	Renewable resource-based biodegradable materials	185:232	Renewable resource-based biodegradable materials	185:232	Renewable resource-based biodegradable materials attract more attention than petroleum-based biodegradable materials to support the sustainable development of ecology.
32720020	8	37	theme	obtained	1347:1354	arg1	microcapsules					1356:1368	obtained microcapsules	1347:1368	obtained microcapsules	1347:1368	FTIR analysis was performed on obtained microcapsules, confirming the molecular interactions between GA and CH.
32720020	3	38	theme	essential	741:749	arg1	OOEO					756:759	OOEO	756:759	OOEO	756:759	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	3	38	theme	essential	741:749	arg1	oil					751:753	Origanum onites L. essential oil	722:753	Origanum onites L. essential oil (OOEO)	722:760	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	7	39	theme	Scanning	1217:1224	arg1	microscopy					1235:1244	Scanning electron microscopy	1217:1244	Scanning electron microscopy analysis	1217:1253	Scanning electron microscopy analysis showed that OOEO microcapsule samples had a spherical shape.
32720020	2	40	theme	technological	530:542	arg1	advances					544:551	technological advances	530:551	technological advances in different industries	530:575	Obtaining collagen hydrolysate (CH) from hide fleshing wastes of leather industry is an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries.
32720020	1	41	theme	ecology	344:350	arg1	development					329:339	the sustainable development	313:339	the sustainable development of ecology	313:350	Renewable resource-based biodegradable materials attract more attention than petroleum-based biodegradable materials to support the sustainable development of ecology.
32720020	0	42	theme	L.	138:139	arg1	oil					151:153	Origanum onites L. essential oil	122:153	Origanum onites L. essential oil through complex coacervation	122:182	Gum arabic and collagen hydrolysate extracted from hide fleshing wastes as novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation.
32720020	2	43	from	advances	544:551	arg1	industries					566:575	different industries	556:575	different industries	556:575	Obtaining collagen hydrolysate (CH) from hide fleshing wastes of leather industry is an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries.
32720020	3	44	theme	gum	621:623	arg1	GA					633:634	GA	633:634	GA	633:634	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	3	44	theme	gum	621:623	arg1	arabic					625:630	gum arabic	621:630	gum arabic (GA)	621:635	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	1	45	theme	resource-based	195:208	arg1	materials					224:232	Renewable resource-based biodegradable materials	185:232	Renewable resource-based biodegradable materials	185:232	Renewable resource-based biodegradable materials attract more attention than petroleum-based biodegradable materials to support the sustainable development of ecology.
32720020	2	46	theme	friendly	457:464	arg1	way					466:468	an environmentally friendly way	438:468	an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries	438:575	Obtaining collagen hydrolysate (CH) from hide fleshing wastes of leather industry is an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries.
32720020	0	47	theme	onites	131:136	arg1	oil					151:153	Origanum onites L. essential oil	122:153	Origanum onites L. essential oil through complex coacervation	122:182	Gum arabic and collagen hydrolysate extracted from hide fleshing wastes as novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation.
32720020	3	48	theme	CH	641:642	arg1	materials					697:705	wall materials	692:705	wall materials	692:705	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	3	48	theme	CH	641:642	arg1	ratios					611:616	2:1, 1:1, and 1 2 ratios	593:616	2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste	593:677	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	2	49	theme	multifunctional	481:495	arg1	materials					497:505	multifunctional materials	481:505	multifunctional materials that can contribute to technological advances in different industries	481:575	Obtaining collagen hydrolysate (CH) from hide fleshing wastes of leather industry is an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries.
32720020	2	50	theme	environmentally	441:455	arg1	way					466:468	an environmentally friendly way	438:468	an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries	438:575	Obtaining collagen hydrolysate (CH) from hide fleshing wastes of leather industry is an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries.
32720020	3	51	theme	complex	772:778	arg1	method					793:798	the complex coacervation method	768:798	the complex coacervation method	768:798	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	0	52	theme	oil	151:153	arg1	microencapsulation					100:117	microencapsulation	100:117	microencapsulation of Origanum onites L. essential oil through complex coacervation	100:182	Gum arabic and collagen hydrolysate extracted from hide fleshing wastes as novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation.
32720020	2	53	theme	different	556:564	arg1	industries					566:575	different industries	556:575	different industries	556:575	Obtaining collagen hydrolysate (CH) from hide fleshing wastes of leather industry is an environmentally friendly way to develop multifunctional materials that can contribute to technological advances in different industries.
32720020	5	54	theme	encapsulation	1035:1047	arg1	yield					1049:1053	high encapsulation yield	1030:1053	high encapsulation yield	1030:1053	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	4	55	theme	thermal	902:908	arg1	stability					910:918	thermal stability	902:918	thermal stability	902:918	The encapsulation yield and efficiency, functional group composition, particle size, morphology, and thermal stability of the obtained OOEO microcapsules were characterized.
32720020	9	56	theme	ideal	1473:1477	arg1	material					1484:1491	an ideal wall material	1470:1491	an ideal wall material using GA and CH for microencapsulation of essential oils	1470:1548	These findings can be useful in designing an ideal wall material using GA and CH for microencapsulation of essential oils by the complex coacervation method.
32720020	5	57	theme	water	1144:1148	arg1	activity					1150:1157	low water activity	1140:1157	low water activity	1140:1157	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	3	58	used	used	684:687	arg2	ratios					611:616	2:1, 1:1, and 1 2 ratios	593:616	2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste	593:677	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	3	58	used	used	684:687	arg2	materials					697:705	wall materials	692:705	wall materials	692:705	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	0	59	theme	essential	141:149	arg1	oil					151:153	Origanum onites L. essential oil	122:153	Origanum onites L. essential oil through complex coacervation	122:182	Gum arabic and collagen hydrolysate extracted from hide fleshing wastes as novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation.
32720020	5	60	theme	good	1082:1085	arg1	properties					1098:1107	good functional properties	1082:1107	good functional properties such as uniform morphology and low water activity	1082:1157	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	5	60	theme	good	1082:1085	arg1	activity					1150:1157	low water activity	1140:1157	low water activity	1140:1157	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	5	60	theme	good	1082:1085	arg1	morphology					1125:1134	uniform morphology	1117:1134	uniform morphology	1117:1134	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	0	61	theme	complex	163:169	arg1	coacervation					171:182	complex coacervation	163:182	complex coacervation	163:182	Gum arabic and collagen hydrolysate extracted from hide fleshing wastes as novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation.
32720020	3	62	theme	arabic	625:630	arg1	materials					697:705	wall materials	692:705	wall materials	692:705	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	3	62	theme	arabic	625:630	arg1	ratios					611:616	2:1, 1:1, and 1 2 ratios	593:616	2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste	593:677	In this study, 2:1, 1:1, and 1 2 ratios of gum arabic (GA) and CH extracted from hide fleshing waste were used as wall materials to encapsulate Origanum onites L. essential oil (OOEO) using the complex coacervation method.
32720020	9	63	theme	coacervation	1565:1576	arg1	method					1578:1583	the complex coacervation method	1553:1583	the complex coacervation method	1553:1583	These findings can be useful in designing an ideal wall material using GA and CH for microencapsulation of essential oils by the complex coacervation method.
32720020	9	64	theme	complex	1557:1563	arg1	coacervation					1565:1576	the complex coacervation	1553:1576	the complex coacervation method	1553:1583	These findings can be useful in designing an ideal wall material using GA and CH for microencapsulation of essential oils by the complex coacervation method.
32720020	6	65	theme	mass	1169:1172	arg1	ratio					1174:1178	The best mass ratio	1160:1178	The best mass ratio for the biopolymers (GA:CH)	1160:1206	The best mass ratio for the biopolymers (GA:CH) was 1:1.
32720020	6	65	theme	mass	1169:1172	arg1	1:1					1212:1214	1:1	1212:1214	1:1	1212:1214	The best mass ratio for the biopolymers (GA:CH) was 1:1.
32720020	4	66	theme	OOEO	936:939	arg1	microcapsules					941:953	the obtained OOEO microcapsules	923:953	the obtained OOEO microcapsules	923:953	The encapsulation yield and efficiency, functional group composition, particle size, morphology, and thermal stability of the obtained OOEO microcapsules were characterized.
32720020	7	67	theme	spherical	1299:1307	arg1	shape					1309:1313	a spherical shape	1297:1313	a spherical shape	1297:1313	Scanning electron microscopy analysis showed that OOEO microcapsule samples had a spherical shape.
32720020	7	68	contain	had	1293:1295	arg2	shape					1309:1313	a spherical shape	1297:1313	a spherical shape	1297:1313	Scanning electron microscopy analysis showed that OOEO microcapsule samples had a spherical shape.
32720020	7	68	contain	had	1293:1295	arg1	samples					1285:1291	OOEO microcapsule samples	1267:1291	OOEO microcapsule samples	1267:1291	Scanning electron microscopy analysis showed that OOEO microcapsule samples had a spherical shape.
32720020	5	69	theme	obtained	1003:1010	arg1	microcapsules					1012:1024	the obtained microcapsules	999:1024	the obtained microcapsules	999:1024	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	7	70	theme	electron	1226:1233	arg1	microscopy					1235:1244	Scanning electron microscopy	1217:1244	Scanning electron microscopy analysis	1217:1253	Scanning electron microscopy analysis showed that OOEO microcapsule samples had a spherical shape.
32720020	5	71	contain	had	1026:1028	arg2	yield					1049:1053	high encapsulation yield	1030:1053	high encapsulation yield	1030:1053	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	5	71	contain	had	1026:1028	arg2	properties					1098:1107	good functional properties	1082:1107	good functional properties such as uniform morphology and low water activity	1082:1157	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	5	71	contain	had	1026:1028	arg1	microcapsules					1012:1024	the obtained microcapsules	999:1024	the obtained microcapsules	999:1024	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	5	71	contain	had	1026:1028	arg2	activity					1150:1157	low water activity	1140:1157	low water activity	1140:1157	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	5	71	contain	had	1026:1028	arg2	morphology					1125:1134	uniform morphology	1117:1134	uniform morphology	1117:1134	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	5	71	contain	had	1026:1028	arg2	efficiency					1059:1068	efficiency	1059:1068	efficiency	1059:1068	The results showed that the obtained microcapsules had high encapsulation yield and efficiency, as well as good functional properties such as uniform morphology and low water activity.
32720020	1	72	theme	petroleum-based	262:276	arg1	materials					292:300	petroleum-based biodegradable materials	262:300	petroleum-based biodegradable materials	262:300	Renewable resource-based biodegradable materials attract more attention than petroleum-based biodegradable materials to support the sustainable development of ecology.
32720020	0	73	theme	fleshing	56:63	arg1	wastes					65:70	hide fleshing wastes	51:70	hide fleshing wastes as novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation	51:182	Gum arabic and collagen hydrolysate extracted from hide fleshing wastes as novel wall materials for microencapsulation of Origanum onites L. essential oil through complex coacervation.
32720020	7	74	theme	OOEO	1267:1270	arg1	samples					1285:1291	OOEO microcapsule samples	1267:1291	OOEO microcapsule samples	1267:1291	Scanning electron microscopy analysis showed that OOEO microcapsule samples had a spherical shape.
32720020	7	75	theme	microscopy	1235:1244	arg1	analysis					1246:1253	Scanning electron microscopy analysis	1217:1253	Scanning electron microscopy analysis	1217:1253	Scanning electron microscopy analysis showed that OOEO microcapsule samples had a spherical shape.
32720020	1	76	theme	biodegradable	278:290	arg1	materials					292:300	petroleum-based biodegradable materials	262:300	petroleum-based biodegradable materials	262:300	Renewable resource-based biodegradable materials attract more attention than petroleum-based biodegradable materials to support the sustainable development of ecology.
32888992	0	0	theme	release	95:101	arg1	carrier					103:109	sustained release carrier	85:109	sustained release carrier	85:109	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.
32888992	8	1	theme	carboxymethylated	962:978	arg1	w/v					1007:1009	w/v	1007:1009	w/v	1007:1009	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	1	theme	carboxymethylated	962:978	arg1	%					1005:1005	carboxymethylated Cassia galactomannan-2.85%	962:1005	carboxymethylated Cassia galactomannan-2.85%	962:1005	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	0	2	theme	sustained	85:93	arg1	carrier					103:109	sustained release carrier	85:109	sustained release carrier	85:109	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.
32888992	8	3	theme	diclofenac	1113:1122	arg1	diclofenac					1113:1122	diclofenac	1113:1122	diclofenac	1113:1122	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	3	theme	diclofenac	1113:1122	arg1	%					1108:1108	93.32%	1103:1108	93.32% of diclofenac	1103:1122	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	1	4	theme	Williamsons	186:196	arg1	synthesis					198:206	Williamsons synthesis	186:206	Williamsons synthesis	186:206	Carboxymethylation of Cassia obtusifolia galactomannan was carried out by Williamsons synthesis.
32888992	5	5	theme	crystallinity	682:694	arg1	degree					672:677	degree	672:677	degree of crystallinity	672:694	The results of X-ray diffraction and scanning electron microscopy studies indicated increase in degree of crystallinity.
32888992	6	6	theme	modified	701:708	arg1	gum					710:712	The modified gum	697:712	The modified gum	697:712	The modified gum was used for preparing diclofenac sodium-loaded, Ca2+-gelled beads which were coated with gastroresistant Eudragit-L100.
32888992	8	7	theme	optimal	923:929	arg1	formulation					931:941	The optimal formulation	919:941	The optimal formulation of beads	919:950	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	6	8	dep	sodium-loaded	748:760	arg1	Ca2+-gelled					763:773	Ca2+-gelled	763:773	Ca2+-gelled	763:773	The modified gum was used for preparing diclofenac sodium-loaded, Ca2+-gelled beads which were coated with gastroresistant Eudragit-L100.
32888992	6	9	theme	gastroresistant	804:818	arg1	Eudragit-L100					820:832	gastroresistant Eudragit-L100	804:832	gastroresistant Eudragit-L100	804:832	The modified gum was used for preparing diclofenac sodium-loaded, Ca2+-gelled beads which were coated with gastroresistant Eudragit-L100.
32888992	9	10	theme	first-order	1170:1180	arg1	kinetics					1182:1189	first-order kinetics	1170:1189	first-order kinetics	1170:1189	The release of diclofenac followed first-order kinetics by Super case-II transport.
32888992	4	11	from	elastic	556:562	arg1	characteristics					535:549	the compression characteristics	519:549	the compression characteristics from elastic to plastic	519:573	Carboxymethylation was observed to increase the powder flow, solubility and swelling, while decrease the viscosity and alter the compression characteristics from elastic to plastic.
32888992	4	12	theme	powder	442:447	arg1	flow					449:452	the powder flow	438:452	the powder flow	438:452	Carboxymethylation was observed to increase the powder flow, solubility and swelling, while decrease the viscosity and alter the compression characteristics from elastic to plastic.
32888992	8	13	theme	calcium	1015:1021	arg1	w/v					1037:1039	w/v	1037:1039	w/v	1037:1039	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	13	theme	calcium	1015:1021	arg1	%					1035:1035	calcium chloride -15%	1015:1035	calcium chloride -15%	1015:1035	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	0	14	theme	Carboxymethyl	0:12	arg1	modification					14:25	Carboxymethyl modification	0:25	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.	0:110	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.
32888992	10	15	theme	Cassia	1239:1244	arg1	galactomannan					1246:1258	carboxymethyl Cassia galactomannan	1225:1258	carboxymethyl Cassia galactomannan	1225:1258	Thus, carboxymethyl Cassia galactomannan appears suitable for sustained drug delivery.
32888992	9	16	theme	Super	1194:1198	arg1	transport					1208:1216	Super case-II transport	1194:1216	Super case-II transport	1194:1216	The release of diclofenac followed first-order kinetics by Super case-II transport.
32888992	0	17	theme	Cassia	30:35	arg1	galactomannan					49:61	Cassia obtusifolia galactomannan	30:61	Cassia obtusifolia galactomannan	30:61	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.
32888992	10	18	theme	carboxymethyl	1225:1237	arg1	galactomannan					1246:1258	carboxymethyl Cassia galactomannan	1225:1258	carboxymethyl Cassia galactomannan	1225:1258	Thus, carboxymethyl Cassia galactomannan appears suitable for sustained drug delivery.
32888992	8	19	theme	%	1108:1108	arg1	%					1108:1108	93.32%	1103:1108	93.32% of diclofenac	1103:1122	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	19	theme	%	1108:1108	arg1	diclofenac					1113:1122	diclofenac	1113:1122	diclofenac	1113:1122	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	19	theme	%	1108:1108	arg1	release					1092:1098	release	1092:1098	release of 93.32% of diclofenac over 24 h	1092:1132	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	19	theme	%	1108:1108	arg1	%					1067:1067	yield -185.4%	1055:1067	yield -185.4%	1055:1067	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	19	theme	%	1108:1108	arg1	%					1086:1086	entrapment-95.41%	1070:1086	entrapment-95.41%	1070:1086	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	20	theme	chloride	1023:1030	arg1	w/v					1037:1039	w/v	1037:1039	w/v	1037:1039	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	20	theme	chloride	1023:1030	arg1	%					1035:1035	calcium chloride -15%	1015:1035	calcium chloride -15%	1015:1035	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	21	theme	yield	1055:1059	arg1	%					1108:1108	93.32%	1103:1108	93.32% of diclofenac	1103:1122	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	21	theme	yield	1055:1059	arg1	diclofenac					1113:1122	diclofenac	1113:1122	diclofenac	1113:1122	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	21	theme	yield	1055:1059	arg1	%					1067:1067	yield -185.4%	1055:1067	yield -185.4%	1055:1067	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	3	22	theme	carboxymethyl	345:357	arg1	substitution					359:370	carboxymethyl substitution	345:370	carboxymethyl substitution	345:370	The degree of carboxymethyl substitution was found to be 1.69.
32888992	0	23	theme	galactomannan	49:61	arg1	modification					14:25	Carboxymethyl modification	0:25	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.	0:110	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.
32888992	2	24	theme	1H-Nuclear	287:296	arg1	resonance					307:315	Fourier-transform infrared and 1H-Nuclear magnetic resonance	256:315	resonance	307:315	Modification of galactomannan was confirmed by Fourier-transform infrared and 1H-Nuclear magnetic resonance spectroscopy.
32888992	0	25	theme	obtusifolia	37:47	arg1	galactomannan					49:61	Cassia obtusifolia galactomannan	30:61	Cassia obtusifolia galactomannan	30:61	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.
32888992	7	26	theme	composite	888:896	arg1	design					911:916	central composite experimental design	880:916	central composite experimental design	880:916	The formulation of beads was optimized using central composite experimental design.
32888992	4	27	theme	compression	523:533	arg1	characteristics					535:549	the compression characteristics	519:549	the compression characteristics from elastic to plastic	519:573	Carboxymethylation was observed to increase the powder flow, solubility and swelling, while decrease the viscosity and alter the compression characteristics from elastic to plastic.
32888992	5	28	theme	scanning	613:620	arg1	microscopy					631:640	scanning electron microscopy	613:640	scanning electron microscopy	613:640	The results of X-ray diffraction and scanning electron microscopy studies indicated increase in degree of crystallinity.
32888992	7	29	theme	central	880:886	arg1	design					911:916	central composite experimental design	880:916	central composite experimental design	880:916	The formulation of beads was optimized using central composite experimental design.
32888992	7	30	theme	experimental	898:909	arg1	design					911:916	central composite experimental design	880:916	central composite experimental design	880:916	The formulation of beads was optimized using central composite experimental design.
32888992	10	31	theme	sustained	1281:1289	arg1	delivery					1296:1303	sustained drug delivery	1281:1303	sustained drug delivery	1281:1303	Thus, carboxymethyl Cassia galactomannan appears suitable for sustained drug delivery.
32888992	2	32	theme	infrared	274:281	arg1	spectroscopy					317:328	Fourier-transform infrared and 1H-Nuclear magnetic resonance spectroscopy	256:328	Fourier-transform infrared and 1H-Nuclear magnetic resonance spectroscopy	256:328	Modification of galactomannan was confirmed by Fourier-transform infrared and 1H-Nuclear magnetic resonance spectroscopy.
32888992	5	33	theme	electron	622:629	arg1	microscopy					631:640	scanning electron microscopy	613:640	scanning electron microscopy	613:640	The results of X-ray diffraction and scanning electron microscopy studies indicated increase in degree of crystallinity.
32888992	1	34	theme	Cassia	134:139	arg1	galactomannan					153:165	Cassia obtusifolia galactomannan	134:165	Cassia obtusifolia galactomannan	134:165	Carboxymethylation of Cassia obtusifolia galactomannan was carried out by Williamsons synthesis.
32888992	6	35	used	used	718:721	arg2	gum					710:712	The modified gum	697:712	The modified gum	697:712	The modified gum was used for preparing diclofenac sodium-loaded, Ca2+-gelled beads which were coated with gastroresistant Eudragit-L100.
32888992	5	36	theme	microscopy	631:640	arg1	studies					642:648	X-ray diffraction and scanning electron microscopy studies	591:648	X-ray diffraction and scanning electron microscopy studies	591:648	The results of X-ray diffraction and scanning electron microscopy studies indicated increase in degree of crystallinity.
32888992	1	37	theme	obtusifolia	141:151	arg1	galactomannan					153:165	Cassia obtusifolia galactomannan	134:165	Cassia obtusifolia galactomannan	134:165	Carboxymethylation of Cassia obtusifolia galactomannan was carried out by Williamsons synthesis.
32888992	6	38	theme	sodium-loaded	748:760	arg1	beads					775:779	diclofenac sodium-loaded, Ca2+-gelled beads	737:779	diclofenac sodium-loaded, Ca2+-gelled beads which were coated with gastroresistant Eudragit-L100	737:832	The modified gum was used for preparing diclofenac sodium-loaded, Ca2+-gelled beads which were coated with gastroresistant Eudragit-L100.
32888992	0	39	mod	modification	14:25	arg3	Carboxymethyl					0:12	Carboxymethyl modification	0:25	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.	0:110	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.
32888992	0	39	mod	modification	14:25	arg1	galactomannan					49:61	Cassia obtusifolia galactomannan	30:61	Cassia obtusifolia galactomannan	30:61	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.
32888992	0	39	mod	modification	14:25	arg1	evaluation					71:80	its evaluation	67:80	its evaluation as sustained release carrier	67:109	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.
32888992	3	40	theme	substitution	359:370	arg1	degree					335:340	The degree	331:340	The degree of carboxymethyl substitution	331:370	The degree of carboxymethyl substitution was found to be 1.69.
32888992	3	40	theme	substitution	359:370	arg1	1.69					388:391	1.69	388:391	1.69	388:391	The degree of carboxymethyl substitution was found to be 1.69.
32888992	8	41	contain	contained	952:960	arg2	%					1005:1005	carboxymethylated Cassia galactomannan-2.85%	962:1005	carboxymethylated Cassia galactomannan-2.85%	962:1005	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	41	contain	contained	952:960	arg2	w/v					1037:1039	w/v	1037:1039	w/v	1037:1039	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	41	contain	contained	952:960	arg1	formulation					931:941	The optimal formulation	919:941	The optimal formulation of beads	919:950	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	41	contain	contained	952:960	arg2	%					1035:1035	calcium chloride -15%	1015:1035	calcium chloride -15%	1015:1035	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	41	contain	contained	952:960	arg2	w/v					1007:1009	w/v	1007:1009	w/v	1007:1009	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	5	42	theme	studies	642:648	arg1	results					580:586	The results	576:586	The results of X-ray diffraction and scanning electron microscopy studies	576:648	The results of X-ray diffraction and scanning electron microscopy studies indicated increase in degree of crystallinity.
32888992	1	43	theme	galactomannan	153:165	arg1	Carboxymethylation					112:129	Carboxymethylation	112:129	Carboxymethylation of Cassia obtusifolia galactomannan	112:165	Carboxymethylation of Cassia obtusifolia galactomannan was carried out by Williamsons synthesis.
32888992	6	44	theme	diclofenac	737:746	arg1	beads					775:779	diclofenac sodium-loaded, Ca2+-gelled beads	737:779	diclofenac sodium-loaded, Ca2+-gelled beads which were coated with gastroresistant Eudragit-L100	737:832	The modified gum was used for preparing diclofenac sodium-loaded, Ca2+-gelled beads which were coated with gastroresistant Eudragit-L100.
32888992	8	45	dep	contained	952:960	arg1	showed					1048:1053	showed	1048:1053	showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h	1048:1132	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	9	46	theme	case-II	1200:1206	arg1	transport					1208:1216	Super case-II transport	1194:1216	Super case-II transport	1194:1216	The release of diclofenac followed first-order kinetics by Super case-II transport.
32888992	2	47	theme	galactomannan	225:237	arg1	Modification					209:220	Modification	209:220	Modification of galactomannan	209:237	Modification of galactomannan was confirmed by Fourier-transform infrared and 1H-Nuclear magnetic resonance spectroscopy.
32888992	2	48	theme	resonance	307:315	arg1	spectroscopy					317:328	Fourier-transform infrared and 1H-Nuclear magnetic resonance spectroscopy	256:328	Fourier-transform infrared and 1H-Nuclear magnetic resonance spectroscopy	256:328	Modification of galactomannan was confirmed by Fourier-transform infrared and 1H-Nuclear magnetic resonance spectroscopy.
32888992	5	49	theme	X-ray	591:595	arg1	diffraction					597:607	X-ray diffraction	591:607	X-ray diffraction	591:607	The results of X-ray diffraction and scanning electron microscopy studies indicated increase in degree of crystallinity.
32888992	8	50	theme	beads	946:950	arg1	formulation					931:941	The optimal formulation	919:941	The optimal formulation of beads	919:950	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	10	51	theme	drug	1291:1294	arg1	delivery					1296:1303	sustained drug delivery	1281:1303	sustained drug delivery	1281:1303	Thus, carboxymethyl Cassia galactomannan appears suitable for sustained drug delivery.
32888992	0	52	theme	evaluation	71:80	arg1	modification					14:25	Carboxymethyl modification	0:25	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.	0:110	Carboxymethyl modification of Cassia obtusifolia galactomannan and its evaluation as sustained release carrier.
32888992	9	53	theme	diclofenac	1150:1159	arg1	release					1139:1145	The release	1135:1145	The release of diclofenac	1135:1159	The release of diclofenac followed first-order kinetics by Super case-II transport.
32888992	2	54	theme	magnetic	298:305	arg1	resonance					307:315	Fourier-transform infrared and 1H-Nuclear magnetic resonance	256:315	resonance	307:315	Modification of galactomannan was confirmed by Fourier-transform infrared and 1H-Nuclear magnetic resonance spectroscopy.
32888992	5	55	theme	diffraction	597:607	arg1	studies					642:648	X-ray diffraction and scanning electron microscopy studies	591:648	X-ray diffraction and scanning electron microscopy studies	591:648	The results of X-ray diffraction and scanning electron microscopy studies indicated increase in degree of crystallinity.
32888992	8	56	theme	Cassia	980:985	arg1	w/v					1007:1009	w/v	1007:1009	w/v	1007:1009	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	8	56	theme	Cassia	980:985	arg1	%					1005:1005	carboxymethylated Cassia galactomannan-2.85%	962:1005	carboxymethylated Cassia galactomannan-2.85%	962:1005	The optimal formulation of beads contained carboxymethylated Cassia galactomannan-2.85%,w/v and calcium chloride -15%,w/v, which showed yield -185.4%, entrapment-95.41% and release of 93.32% of diclofenac over 24 h.
32888992	7	57	theme	beads	854:858	arg1	formulation					839:849	The formulation	835:849	The formulation of beads	835:858	The formulation of beads was optimized using central composite experimental design.
32735922	7	0	theme	photoelectron	1218:1230	arg1	spectroscopy					1232:1243	X-ray photoelectron spectroscopy	1212:1243	X-ray photoelectron spectroscopy (XPS)	1212:1249	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
32735922	7	0	theme	photoelectron	1218:1230	arg1	XPS					1246:1248	XPS	1246:1248	XPS	1246:1248	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
32735922	1	1	theme	IV	307:308	arg1	CS-Zr-PEPA					328:337	CS-Zr-PEPA	328:337	CS-Zr-PEPA	328:337	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	1	1	theme	IV	307:308	arg1	beads					321:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads	251:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions	251:361	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	1	2	theme	phosphorus	231:240	arg1	mechanism					218:226	mechanism	218:226	mechanism	218:226	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	1	2	theme	phosphorus	231:240	arg1	performance					202:212	the adsorption performance	187:212	the adsorption performance	187:212	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	2	3	theme	beads	434:438	arg1	morphology					368:377	The morphology	364:377	The morphology	364:377	The morphology, functional groups, and surface area of the CS-Zr-PEPA beads were characterized by SEM, FTIR, and BET analysis.
32735922	2	3	theme	beads	434:438	arg1	groups					391:396	functional groups	380:396	functional groups	380:396	The morphology, functional groups, and surface area of the CS-Zr-PEPA beads were characterized by SEM, FTIR, and BET analysis.
32735922	2	3	theme	beads	434:438	arg1	beads					434:438	the CS-Zr-PEPA beads	419:438	the CS-Zr-PEPA beads	419:438	The morphology, functional groups, and surface area of the CS-Zr-PEPA beads were characterized by SEM, FTIR, and BET analysis.
32735922	2	3	theme	beads	434:438	arg1	area					411:414	surface area	403:414	surface area of the CS-Zr-PEPA beads	403:438	The morphology, functional groups, and surface area of the CS-Zr-PEPA beads were characterized by SEM, FTIR, and BET analysis.
32735922	6	4	theme	CS-Zr-PEPA	972:981	arg1	beads					983:987	CS-Zr-PEPA beads	972:987	CS-Zr-PEPA beads	972:987	The reusability studies of CS-Zr-PEPA beads were carried out.
32735922	1	5	from	solutions	353:361	arg1	CS-Zr-PEPA					328:337	CS-Zr-PEPA	328:337	CS-Zr-PEPA	328:337	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	1	5	from	solutions	353:361	arg1	beads					321:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads	251:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions	251:361	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	1	6	theme	composite	311:319	arg1	CS-Zr-PEPA					328:337	CS-Zr-PEPA	328:337	CS-Zr-PEPA	328:337	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	1	6	theme	composite	311:319	arg1	beads					321:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads	251:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions	251:361	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	7	7	dep	beads	1179:1183	arg1	the					1168:1170	the	1168:1170	the	1168:1170	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
32735922	3	8	theme	adsorption	497:506	arg1	experiments					508:518	Batch adsorption experiments	491:518	Batch adsorption experiments	491:518	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	9	9	theme	effective	1447:1455	arg1	removal					1457:1463	effective removal	1447:1463	effective removal	1447:1463	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	0	10	theme	efficient	85:93	arg1	removal					95:101	highly efficient removal	78:101	highly efficient removal	78:101	Development of polyaminated chitosan-zirconium(IV) complex bead adsorbent for highly efficient removal and recovery of phosphorus in aqueous solutions.
32735922	5	11	theme	other	786:790	arg1	beads					801:805	other CS-based beads	786:805	other CS-based beads	786:805	In comparison with other CS-based beads, the CS-Zr-PEPA had a greater affinity towards P and exhibited a maximum adsorption capacity of 103.96 mg-P/g predicted by Langmuir mode.
32735922	9	12	from	wastewater	1498:1507	arg1	recovery					1469:1476	recovery	1469:1476	recovery of P from water and wastewater	1469:1507	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	9	12	from	wastewater	1498:1507	arg1	removal					1457:1463	effective removal	1447:1463	effective removal	1447:1463	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	5	13	with	comparison	770:779	arg1	beads					801:805	other CS-based beads	786:805	other CS-based beads	786:805	In comparison with other CS-based beads, the CS-Zr-PEPA had a greater affinity towards P and exhibited a maximum adsorption capacity of 103.96 mg-P/g predicted by Langmuir mode.
32735922	0	14	from	solutions	141:149	arg1	removal					95:101	highly efficient removal	78:101	highly efficient removal	78:101	Development of polyaminated chitosan-zirconium(IV) complex bead adsorbent for highly efficient removal and recovery of phosphorus in aqueous solutions.
32735922	0	14	from	solutions	141:149	arg1	recovery					107:114	recovery	107:114	recovery	107:114	Development of polyaminated chitosan-zirconium(IV) complex bead adsorbent for highly efficient removal and recovery of phosphorus in aqueous solutions.
32735922	7	15	theme	P-adsorbed	1189:1198	arg1	beads					1200:1204	P-adsorbed beads	1189:1204	P-adsorbed beads	1189:1204	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
32735922	8	16	theme	column	1256:1261	arg1	performance					1263:1273	The column performance	1252:1273	The column performance of CS-Zr-PEPA beads	1252:1293	The column performance of CS-Zr-PEPA beads was tested with P-containing wastewater.
32735922	7	17	theme	beads	1200:1204	arg1	characteristics					1149:1163	physicochemical characteristics	1133:1163	physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS)	1133:1249	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
32735922	6	18	theme	beads	983:987	arg1	studies					961:967	The reusability studies	945:967	The reusability studies of CS-Zr-PEPA beads	945:987	The reusability studies of CS-Zr-PEPA beads were carried out.
32735922	5	19	contain	had	823:825	arg1	CS-Zr-PEPA					812:821	the CS-Zr-PEPA	808:821	the CS-Zr-PEPA	808:821	In comparison with other CS-based beads, the CS-Zr-PEPA had a greater affinity towards P and exhibited a maximum adsorption capacity of 103.96 mg-P/g predicted by Langmuir mode.
32735922	5	19	contain	had	823:825	arg2	affinity					837:844	a greater affinity	827:844	a greater affinity towards P	827:854	In comparison with other CS-based beads, the CS-Zr-PEPA had a greater affinity towards P and exhibited a maximum adsorption capacity of 103.96 mg-P/g predicted by Langmuir mode.
32735922	4	20	theme	adsorbent	739:747	arg1	kinetics					675:682	The adsorption kinetics	660:682	The adsorption kinetics	660:682	The adsorption kinetics, equilibrium isotherms and adsorption stability of the adsorbent were scrutinized.
32735922	4	20	theme	adsorbent	739:747	arg1	isotherms					697:705	equilibrium isotherms	685:705	equilibrium isotherms	685:705	The adsorption kinetics, equilibrium isotherms and adsorption stability of the adsorbent were scrutinized.
32735922	4	20	theme	adsorbent	739:747	arg1	stability					722:730	adsorption stability	711:730	adsorption stability	711:730	The adsorption kinetics, equilibrium isotherms and adsorption stability of the adsorbent were scrutinized.
32735922	5	21	theme	greater	829:835	arg1	affinity					837:844	a greater affinity	827:844	a greater affinity towards P	827:854	In comparison with other CS-based beads, the CS-Zr-PEPA had a greater affinity towards P and exhibited a maximum adsorption capacity of 103.96 mg-P/g predicted by Langmuir mode.
32735922	2	22	theme	surface	403:409	arg1	area					411:414	surface area	403:414	surface area of the CS-Zr-PEPA beads	403:438	The morphology, functional groups, and surface area of the CS-Zr-PEPA beads were characterized by SEM, FTIR, and BET analysis.
32735922	9	23	theme	CS-Zr-PEPA	1373:1382	arg1	beads					1394:1398	the developed CS-Zr-PEPA composite beads	1359:1398	the developed CS-Zr-PEPA composite beads	1359:1398	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	9	23	theme	CS-Zr-PEPA	1373:1382	arg1	adsorbent					1433:1441	adsorbent	1433:1441	adsorbent	1433:1441	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	7	24	theme	preferable	1036:1045	arg1	sequestration					1047:1059	preferable sequestration	1036:1059	preferable sequestration of P	1036:1064	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
32735922	5	25	theme	103.96 mg-P/g	903:915	arg1	capacity					891:898	a maximum adsorption capacity	870:898	a maximum adsorption capacity of 103.96 mg-P/g predicted by Langmuir mode	870:942	In comparison with other CS-based beads, the CS-Zr-PEPA had a greater affinity towards P and exhibited a maximum adsorption capacity of 103.96 mg-P/g predicted by Langmuir mode.
32735922	1	26	theme	work	168:171	arg1	aim					156:158	The aim	152:158	The aim of this work	152:171	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	2	27	theme	BET	477:479	arg1	analysis					481:488	BET analysis	477:488	BET analysis	477:488	The morphology, functional groups, and surface area of the CS-Zr-PEPA beads were characterized by SEM, FTIR, and BET analysis.
32735922	6	28	theme	reusability	949:959	arg1	studies					961:967	The reusability studies	945:967	The reusability studies of CS-Zr-PEPA beads	945:987	The reusability studies of CS-Zr-PEPA beads were carried out.
32735922	7	29	theme	specific	1074:1081	arg1	interactions					1083:1094	specific interactions	1074:1094	specific interactions	1074:1094	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
32735922	3	30	theme	co-existing	624:634	arg1	anions					636:641	co-existing anions	624:641	co-existing anions	624:641	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	3	31	theme	phosphate	599:607	arg1	concentration					609:621	initial phosphate concentration	591:621	initial phosphate concentration	591:621	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	0	32	theme	chitosan-zirconium	28:45	arg1	complex					51:57	polyaminated chitosan-zirconium(IV) complex	15:57	polyaminated chitosan-zirconium(IV) complex	15:57	Development of polyaminated chitosan-zirconium(IV) complex bead adsorbent for highly efficient removal and recovery of phosphorus in aqueous solutions.
32735922	1	33	theme	polyethyene	251:261	arg1	CS-Zr-PEPA					328:337	CS-Zr-PEPA	328:337	CS-Zr-PEPA	328:337	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	1	33	theme	polyethyene	251:261	arg1	beads					321:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads	251:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions	251:361	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	0	34	theme	phosphorus	119:128	arg1	removal					95:101	highly efficient removal	78:101	highly efficient removal	78:101	Development of polyaminated chitosan-zirconium(IV) complex bead adsorbent for highly efficient removal and recovery of phosphorus in aqueous solutions.
32735922	0	34	theme	phosphorus	119:128	arg1	recovery					107:114	recovery	107:114	recovery	107:114	Development of polyaminated chitosan-zirconium(IV) complex bead adsorbent for highly efficient removal and recovery of phosphorus in aqueous solutions.
32735922	3	35	theme	Batch	491:495	arg1	experiments					508:518	Batch adsorption experiments	491:518	Batch adsorption experiments	491:518	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	2	36	theme	functional	380:389	arg1	groups					391:396	functional groups	380:396	functional groups	380:396	The morphology, functional groups, and surface area of the CS-Zr-PEPA beads were characterized by SEM, FTIR, and BET analysis.
32735922	2	36	theme	functional	380:389	arg1	beads					434:438	the CS-Zr-PEPA beads	419:438	the CS-Zr-PEPA beads	419:438	The morphology, functional groups, and surface area of the CS-Zr-PEPA beads were characterized by SEM, FTIR, and BET analysis.
32735922	0	37	theme	polyaminated	15:26	arg1	complex					51:57	polyaminated chitosan-zirconium(IV) complex	15:57	polyaminated chitosan-zirconium(IV) complex	15:57	Development of polyaminated chitosan-zirconium(IV) complex bead adsorbent for highly efficient removal and recovery of phosphorus in aqueous solutions.
32735922	1	38	theme	polyamine	263:271	arg1	CS-Zr-PEPA					328:337	CS-Zr-PEPA	328:337	CS-Zr-PEPA	328:337	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	1	38	theme	polyamine	263:271	arg1	beads					321:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads	251:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions	251:361	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	7	39	theme	P	1064:1064	arg1	sequestration					1047:1059	preferable sequestration	1036:1059	preferable sequestration of P	1036:1064	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
32735922	3	40	theme	initial	591:597	arg1	concentration					609:621	initial phosphate concentration	591:621	initial phosphate concentration	591:621	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	0	41	dep	bead	59:62	arg1	adsorbent					64:72	adsorbent	64:72	adsorbent	64:72	Development of polyaminated chitosan-zirconium(IV) complex bead adsorbent for highly efficient removal and recovery of phosphorus in aqueous solutions.
32735922	5	42	theme	CS-based	792:799	arg1	beads					801:805	other CS-based beads	786:805	other CS-based beads	786:805	In comparison with other CS-based beads, the CS-Zr-PEPA had a greater affinity towards P and exhibited a maximum adsorption capacity of 103.96 mg-P/g predicted by Langmuir mode.
32735922	2	43	theme	CS-Zr-PEPA	423:432	arg1	beads					434:438	the CS-Zr-PEPA beads	419:438	the CS-Zr-PEPA beads	419:438	The morphology, functional groups, and surface area of the CS-Zr-PEPA beads were characterized by SEM, FTIR, and BET analysis.
32735922	5	44	theme	adsorption	880:889	arg1	capacity					891:898	a maximum adsorption capacity	870:898	a maximum adsorption capacity of 103.96 mg-P/g predicted by Langmuir mode	870:942	In comparison with other CS-based beads, the CS-Zr-PEPA had a greater affinity towards P and exhibited a maximum adsorption capacity of 103.96 mg-P/g predicted by Langmuir mode.
32735922	0	45	theme	aqueous	133:139	arg1	solutions					141:149	aqueous solutions	133:149	aqueous solutions	133:149	Development of polyaminated chitosan-zirconium(IV) complex bead adsorbent for highly efficient removal and recovery of phosphorus in aqueous solutions.
32735922	1	46	theme	aqueous	345:351	arg1	solutions					353:361	aqueous solutions	345:361	aqueous solutions	345:361	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	3	47	theme	different	539:547	arg1	temperature					647:657	temperature	647:657	temperature	647:657	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	3	47	theme	different	539:547	arg1	pH					587:588	solution pH	578:588	solution pH	578:588	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	3	47	theme	different	539:547	arg1	concentration					609:621	initial phosphate concentration	591:621	initial phosphate concentration	591:621	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	3	47	theme	different	539:547	arg1	parameters					559:568	different operating parameters	539:568	different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature	539:657	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	3	47	theme	different	539:547	arg1	anions					636:641	co-existing anions	624:641	co-existing anions	624:641	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	9	48	theme	P	1481:1481	arg1	recovery					1469:1476	recovery	1469:1476	recovery of P from water and wastewater	1469:1507	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	9	48	theme	P	1481:1481	arg1	removal					1457:1463	effective removal	1447:1463	effective removal	1447:1463	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	8	49	theme	beads	1289:1293	arg1	performance					1263:1273	The column performance	1252:1273	The column performance of CS-Zr-PEPA beads	1252:1293	The column performance of CS-Zr-PEPA beads was tested with P-containing wastewater.
32735922	1	50	theme	PEPA	274:277	arg1	CS-Zr-PEPA					328:337	CS-Zr-PEPA	328:337	CS-Zr-PEPA	328:337	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	1	50	theme	PEPA	274:277	arg1	beads					321:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads	251:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions	251:361	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	3	51	theme	operating	549:557	arg1	temperature					647:657	temperature	647:657	temperature	647:657	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	3	51	theme	operating	549:557	arg1	pH					587:588	solution pH	578:588	solution pH	578:588	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	3	51	theme	operating	549:557	arg1	concentration					609:621	initial phosphate concentration	591:621	initial phosphate concentration	591:621	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	3	51	theme	operating	549:557	arg1	parameters					559:568	different operating parameters	539:568	different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature	539:657	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	3	51	theme	operating	549:557	arg1	anions					636:641	co-existing anions	624:641	co-existing anions	624:641	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	1	52	theme	adsorption	191:200	arg1	performance					202:212	the adsorption performance	187:212	the adsorption performance	187:212	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	0	53	theme	complex	51:57	arg1	Development					0:10	Development	0:10	Development of polyaminated chitosan-zirconium(IV) complex	0:57	Development of polyaminated chitosan-zirconium(IV) complex bead adsorbent for highly efficient removal and recovery of phosphorus in aqueous solutions.
32735922	9	54	theme	composite	1384:1392	arg1	beads					1394:1398	the developed CS-Zr-PEPA composite beads	1359:1398	the developed CS-Zr-PEPA composite beads	1359:1398	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	9	54	theme	composite	1384:1392	arg1	adsorbent					1433:1441	adsorbent	1433:1441	adsorbent	1433:1441	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	9	55	used	utilized	1409:1416	arg2	beads					1394:1398	the developed CS-Zr-PEPA composite beads	1359:1398	the developed CS-Zr-PEPA composite beads	1359:1398	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	9	55	used	utilized	1409:1416	arg2	adsorbent					1433:1441	adsorbent	1433:1441	adsorbent	1433:1441	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	5	56	theme	maximum	872:878	arg1	capacity					891:898	a maximum adsorption capacity	870:898	a maximum adsorption capacity of 103.96 mg-P/g predicted by Langmuir mode	870:942	In comparison with other CS-based beads, the CS-Zr-PEPA had a greater affinity towards P and exhibited a maximum adsorption capacity of 103.96 mg-P/g predicted by Langmuir mode.
32735922	7	57	theme	physicochemical	1133:1147	arg1	characteristics					1149:1163	physicochemical characteristics	1133:1163	physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS)	1133:1249	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
32735922	1	58	theme	grafted	280:286	arg1	CS-Zr-PEPA					328:337	CS-Zr-PEPA	328:337	CS-Zr-PEPA	328:337	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	1	58	theme	grafted	280:286	arg1	beads					321:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads	251:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions	251:361	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	0	59	from	recovery	107:114	arg1	solutions					141:149	aqueous solutions	133:149	aqueous solutions	133:149	Development of polyaminated chitosan-zirconium(IV) complex bead adsorbent for highly efficient removal and recovery of phosphorus in aqueous solutions.
32735922	4	60	theme	adsorption	664:673	arg1	kinetics					675:682	The adsorption kinetics	660:682	The adsorption kinetics	660:682	The adsorption kinetics, equilibrium isotherms and adsorption stability of the adsorbent were scrutinized.
32735922	1	61	theme	chitosan-zirconium	288:305	arg1	CS-Zr-PEPA					328:337	CS-Zr-PEPA	328:337	CS-Zr-PEPA	328:337	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	1	61	theme	chitosan-zirconium	288:305	arg1	beads					321:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads	251:325	polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions	251:361	The aim of this work is to examine the adsorption performance and mechanism of phosphorus (P) onto polyethyene polyamine (PEPA) grafted chitosan-zirconium(IV) composite beads (CS-Zr-PEPA) from aqueous solutions.
32735922	9	62	theme	developed	1363:1371	arg1	beads					1394:1398	the developed CS-Zr-PEPA composite beads	1359:1398	the developed CS-Zr-PEPA composite beads	1359:1398	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	9	62	theme	developed	1363:1371	arg1	adsorbent					1433:1441	adsorbent	1433:1441	adsorbent	1433:1441	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	4	63	theme	equilibrium	685:695	arg1	isotherms					697:705	equilibrium isotherms	685:705	equilibrium isotherms	685:705	The adsorption kinetics, equilibrium isotherms and adsorption stability of the adsorbent were scrutinized.
32735922	7	64	theme	CS-Zr-PEPA	1011:1020	arg1	beads					1022:1026	The CS-Zr-PEPA beads	1007:1026	The CS-Zr-PEPA beads	1007:1026	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
32735922	0	65	from	removal	95:101	arg1	solutions					141:149	aqueous solutions	133:149	aqueous solutions	133:149	Development of polyaminated chitosan-zirconium(IV) complex bead adsorbent for highly efficient removal and recovery of phosphorus in aqueous solutions.
32735922	3	66	theme	solution	578:585	arg1	pH					587:588	solution pH	578:588	solution pH	578:588	Batch adsorption experiments were conducted via different operating parameters such as solution pH, initial phosphate concentration, co-existing anions and temperature.
32735922	4	67	theme	adsorption	711:720	arg1	stability					722:730	adsorption stability	711:730	adsorption stability	711:730	The adsorption kinetics, equilibrium isotherms and adsorption stability of the adsorbent were scrutinized.
32735922	8	68	theme	P-containing	1311:1322	arg1	wastewater					1324:1333	P-containing wastewater	1311:1333	P-containing wastewater	1311:1333	The column performance of CS-Zr-PEPA beads was tested with P-containing wastewater.
32735922	8	69	theme	CS-Zr-PEPA	1278:1287	arg1	beads					1289:1293	CS-Zr-PEPA beads	1278:1293	CS-Zr-PEPA beads	1278:1293	The column performance of CS-Zr-PEPA beads was tested with P-containing wastewater.
32735922	5	70	theme	Langmuir	930:937	arg1	mode					939:942	Langmuir mode	930:942	Langmuir mode	930:942	In comparison with other CS-based beads, the CS-Zr-PEPA had a greater affinity towards P and exhibited a maximum adsorption capacity of 103.96 mg-P/g predicted by Langmuir mode.
32735922	9	71	from	water	1488:1492	arg1	recovery					1469:1476	recovery	1469:1476	recovery of P from water and wastewater	1469:1507	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	9	71	from	water	1488:1492	arg1	removal					1457:1463	effective removal	1447:1463	effective removal	1447:1463	Results indicated that the developed CS-Zr-PEPA composite beads could be utilized as a promising adsorbent for effective removal and recovery of P from water and wastewater.
32735922	0	72	from	phosphorus	119:128	arg1	solutions					141:149	aqueous solutions	133:149	aqueous solutions	133:149	Development of polyaminated chitosan-zirconium(IV) complex bead adsorbent for highly efficient removal and recovery of phosphorus in aqueous solutions.
32735922	7	73	theme	virgin	1172:1177	arg1	beads					1179:1183	virgin beads	1172:1183	virgin beads	1172:1183	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
32735922	7	74	theme	beads	1179:1183	arg1	characteristics					1149:1163	physicochemical characteristics	1133:1163	physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS)	1133:1249	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
32735922	7	75	theme	X-ray	1212:1216	arg1	spectroscopy					1232:1243	X-ray photoelectron spectroscopy	1212:1243	X-ray photoelectron spectroscopy (XPS)	1212:1249	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
32735922	7	75	theme	X-ray	1212:1216	arg1	XPS					1246:1248	XPS	1246:1248	XPS	1246:1248	The CS-Zr-PEPA beads exhibit preferable sequestration of P through specific interactions, as further demonstrated by studying physicochemical characteristics of the virgin beads and P-adsorbed beads using X-ray photoelectron spectroscopy (XPS).
33227334	3	0	theme	modified	304:311	arg1	CS					313:314	The modified CS	300:314	The modified CS	300:314	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	6	1	theme	ion	851:853	arg1	uptake					855:860	higher metal ion uptake	838:860	higher metal ion uptake	838:860	Ability of the modified CS to uptake metal ions was investigated by using Cu(NO3)2 where CS/HA/CNT/GA showed higher metal ion uptake than CS/HA/GA.
33227334	5	2	theme	%	563:563	arg1	CS					577:578	The 20% HA modified CS	557:578	The 20% HA modified CS	557:578	The 20% HA modified CS showed the highest thermal stability among CS/HA composites while adding CNT to the matrix in CS/HA/CNT composites enhances their thermal stability.
33227334	1	3	theme	carbon	143:148	arg1	MWCNT					161:165	MWCNT	161:165	MWCNT	161:165	Chitosan (CS) was modified using hydroxyapatite (HA) and multiwalled carbon nanotubes (MWCNT) followed by crosslinking with glutaraldehyde (GA).
33227334	1	3	theme	carbon	143:148	arg1	nanotubes					150:158	multiwalled carbon nanotubes	131:158	multiwalled carbon nanotubes (MWCNT)	131:166	Chitosan (CS) was modified using hydroxyapatite (HA) and multiwalled carbon nanotubes (MWCNT) followed by crosslinking with glutaraldehyde (GA).
33227334	5	4	theme	CS/HA/CNT	674:682	arg1	composites					684:693	CS/HA/CNT composites	674:693	CS/HA/CNT composites	674:693	The 20% HA modified CS showed the highest thermal stability among CS/HA composites while adding CNT to the matrix in CS/HA/CNT composites enhances their thermal stability.
33227334	5	5	theme	HA	565:566	arg1	CS					577:578	The 20% HA modified CS	557:578	The 20% HA modified CS	557:578	The 20% HA modified CS showed the highest thermal stability among CS/HA composites while adding CNT to the matrix in CS/HA/CNT composites enhances their thermal stability.
33227334	3	6	from	700 °C	471:476	arg1	measurement					456:466	measurement	456:466	measurement at 700 °C	456:476	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	3	6	from	700 °C	471:476	arg1	end					449:451	the end	445:451	the end of measurement at 700 °C	445:476	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	4	7	theme	thermal	505:511	arg1	stability					513:521	more thermal stability	500:521	more thermal stability of modified CS	500:536	The treatment showed more thermal stability of modified CS over the blank CS.
33227334	3	8	theme	loss	341:344	arg1	%					346:346	a slight weight loss %	325:346	a slight weight loss %	325:346	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	5	9	theme	modified	568:575	arg1	CS					577:578	The 20% HA modified CS	557:578	The 20% HA modified CS	557:578	The 20% HA modified CS showed the highest thermal stability among CS/HA composites while adding CNT to the matrix in CS/HA/CNT composites enhances their thermal stability.
33227334	8	10	theme	P111F > P121F > P211F > P311F > P221F > P321F	1176:1220	arg1	order					1167:1171	the order	1163:1171	the order of P111F > P121F > P211F > P311F > P221F > P321F	1163:1220	This is concluding the ease of release of FU from the investigated matrices which can be arranged in the order of P111F > P121F > P211F > P311F > P221F > P321F.
33227334	4	11	theme	modified	526:533	arg1	CS					535:536	modified CS	526:536	modified CS	526:536	The treatment showed more thermal stability of modified CS over the blank CS.
33227334	6	12	theme	Cu	803:804	arg1	NO3					806:808	Cu(NO3)2	803:810	Cu(NO3)2 where CS/HA/CNT/GA showed higher metal ion uptake than CS/HA/GA	803:874	Ability of the modified CS to uptake metal ions was investigated by using Cu(NO3)2 where CS/HA/CNT/GA showed higher metal ion uptake than CS/HA/GA.
33227334	3	13	from	end	449:451	arg1	700 °C					471:476	700 °C	471:476	700 °C	471:476	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	3	14	theme	slight	327:332	arg1	%					346:346	a slight weight loss %	325:346	a slight weight loss %	325:346	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	7	15	theme	antitumor	966:974	arg1	drug					982:985	an antitumor model drug	963:985	an antitumor model drug	963:985	Modified CS was preliminary checked for controlled release of 5-fluorouracil (FU), as an antitumor model drug, in aqueous media where the maximum release of FU was obtained after 48 h.
33227334	8	16	from	matrices	1129:1136	arg1	release					1093:1099	release	1093:1099	release of FU from the investigated matrices which can be arranged in the order of P111F > P121F > P211F > P311F > P221F > P321F	1093:1220	This is concluding the ease of release of FU from the investigated matrices which can be arranged in the order of P111F > P121F > P211F > P311F > P221F > P321F.
33227334	8	16	from	matrices	1129:1136	arg1	ease					1085:1088	the ease	1081:1088	the ease of release of FU from the investigated matrices which can be arranged in the order of P111F > P121F > P211F > P311F > P221F > P321F	1081:1220	This is concluding the ease of release of FU from the investigated matrices which can be arranged in the order of P111F > P121F > P211F > P311F > P221F > P321F.
33227334	3	17	theme	measurement	456:466	arg1	end					449:451	the end	445:451	the end of measurement at 700 °C	445:476	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	7	18	dep	preliminary	893:903	arg1	checked					905:911	checked	905:911	checked	905:911	Modified CS was preliminary checked for controlled release of 5-fluorouracil (FU), as an antitumor model drug, in aqueous media where the maximum release of FU was obtained after 48 h.
33227334	3	19	theme	weight	334:339	arg1	%					346:346	a slight weight loss %	325:346	a slight weight loss %	325:346	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	0	20	theme	controlled	41:50	arg1	applications					60:71	controlled release applications	41:71	controlled release applications	41:71	Synthesis of chitosan nanocomposites for controlled release applications.
33227334	7	21	theme	FU	1034:1035	arg1	release					1023:1029	the maximum release	1011:1029	the maximum release of FU	1011:1035	Modified CS was preliminary checked for controlled release of 5-fluorouracil (FU), as an antitumor model drug, in aqueous media where the maximum release of FU was obtained after 48 h.
33227334	3	22	theme	EWL	389:391	arg1	%					393:393	240 °C then extensive weight loss (EWL)%	354:393	240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C	354:476	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	5	23	theme	20	561:562	arg1	%					563:563	%	563:563	%	563:563	The 20% HA modified CS showed the highest thermal stability among CS/HA composites while adding CNT to the matrix in CS/HA/CNT composites enhances their thermal stability.
33227334	0	24	theme	release	52:58	arg1	applications					60:71	controlled release applications	41:71	controlled release applications	41:71	Synthesis of chitosan nanocomposites for controlled release applications.
33227334	7	25	theme	aqueous	991:997	arg1	media					999:1003	aqueous media	991:1003	aqueous media where the maximum release of FU was obtained after 48 h	991:1059	Modified CS was preliminary checked for controlled release of 5-fluorouracil (FU), as an antitumor model drug, in aqueous media where the maximum release of FU was obtained after 48 h.
33227334	0	26	theme	chitosan	13:20	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis of chitosan	0:20	Synthesis of chitosan nanocomposites for controlled release applications.
33227334	4	27	theme	more	500:503	arg1	stability					513:521	more thermal stability	500:521	more thermal stability of modified CS	500:536	The treatment showed more thermal stability of modified CS over the blank CS.
33227334	2	28	theme	thermal	282:288	arg1	analysis					290:297	thermal analysis	282:297	thermal analysis	282:297	The obtained products were characterized and investigated with thermal analysis.
33227334	8	29	theme	FU	1104:1105	arg1	release					1093:1099	release	1093:1099	release of FU from the investigated matrices which can be arranged in the order of P111F > P121F > P211F > P311F > P221F > P321F	1093:1220	This is concluding the ease of release of FU from the investigated matrices which can be arranged in the order of P111F > P121F > P211F > P311F > P221F > P321F.
33227334	3	30	theme	loss	383:386	arg1	%					393:393	240 °C then extensive weight loss (EWL)%	354:393	240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C	354:476	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	6	31	theme	metal	845:849	arg1	uptake					855:860	higher metal ion uptake	838:860	higher metal ion uptake	838:860	Ability of the modified CS to uptake metal ions was investigated by using Cu(NO3)2 where CS/HA/CNT/GA showed higher metal ion uptake than CS/HA/GA.
33227334	5	32	theme	CS/HA	623:627	arg1	composites					629:638	CS/HA composites	623:638	CS/HA composites	623:638	The 20% HA modified CS showed the highest thermal stability among CS/HA composites while adding CNT to the matrix in CS/HA/CNT composites enhances their thermal stability.
33227334	8	33	theme	release	1093:1099	arg1	ease					1085:1088	the ease	1081:1088	the ease of release of FU from the investigated matrices which can be arranged in the order of P111F > P121F > P211F > P311F > P221F > P321F	1081:1220	This is concluding the ease of release of FU from the investigated matrices which can be arranged in the order of P111F > P121F > P211F > P311F > P221F > P321F.
33227334	8	34	theme	investigated	1116:1127	arg1	matrices					1129:1136	the investigated matrices	1112:1136	the investigated matrices which can be arranged in the order of P111F > P121F > P211F > P311F > P221F > P321F	1112:1220	This is concluding the ease of release of FU from the investigated matrices which can be arranged in the order of P111F > P121F > P211F > P311F > P221F > P321F.
33227334	7	35	theme	maximum	1015:1021	arg1	release					1023:1029	the maximum release	1011:1029	the maximum release of FU	1011:1035	Modified CS was preliminary checked for controlled release of 5-fluorouracil (FU), as an antitumor model drug, in aqueous media where the maximum release of FU was obtained after 48 h.
33227334	6	36	theme	higher	838:843	arg1	uptake					855:860	higher metal ion uptake	838:860	higher metal ion uptake	838:860	Ability of the modified CS to uptake metal ions was investigated by using Cu(NO3)2 where CS/HA/CNT/GA showed higher metal ion uptake than CS/HA/GA.
33227334	1	37	with	crosslinking	180:191	arg1	GA					214:215	GA	214:215	GA	214:215	Chitosan (CS) was modified using hydroxyapatite (HA) and multiwalled carbon nanotubes (MWCNT) followed by crosslinking with glutaraldehyde (GA).
33227334	1	37	with	crosslinking	180:191	arg1	glutaraldehyde					198:211	glutaraldehyde	198:211	glutaraldehyde (GA)	198:216	Chitosan (CS) was modified using hydroxyapatite (HA) and multiwalled carbon nanotubes (MWCNT) followed by crosslinking with glutaraldehyde (GA).
33227334	6	38	theme	metal	766:770	arg1	ions					772:775	uptake metal ions	759:775	uptake metal ions	759:775	Ability of the modified CS to uptake metal ions was investigated by using Cu(NO3)2 where CS/HA/CNT/GA showed higher metal ion uptake than CS/HA/GA.
33227334	3	39	theme	extensive	366:374	arg1	%					393:393	240 °C then extensive weight loss (EWL)%	354:393	240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C	354:476	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	5	40	theme	thermal	710:716	arg1	stability					718:726	their thermal stability	704:726	their thermal stability	704:726	The 20% HA modified CS showed the highest thermal stability among CS/HA composites while adding CNT to the matrix in CS/HA/CNT composites enhances their thermal stability.
33227334	6	41	theme	uptake	759:764	arg1	ions					772:775	uptake metal ions	759:775	uptake metal ions	759:775	Ability of the modified CS to uptake metal ions was investigated by using Cu(NO3)2 where CS/HA/CNT/GA showed higher metal ion uptake than CS/HA/GA.
33227334	7	42	theme	controlled	917:926	arg1	release					928:934	controlled release	917:934	controlled release of 5-fluorouracil (FU)	917:957	Modified CS was preliminary checked for controlled release of 5-fluorouracil (FU), as an antitumor model drug, in aqueous media where the maximum release of FU was obtained after 48 h.
33227334	3	43	theme	weight	376:381	arg1	%					393:393	240 °C then extensive weight loss (EWL)%	354:393	240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C	354:476	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	7	44	theme	5-fluorouracil	939:952	arg1	release					928:934	controlled release	917:934	controlled release of 5-fluorouracil (FU)	917:957	Modified CS was preliminary checked for controlled release of 5-fluorouracil (FU), as an antitumor model drug, in aqueous media where the maximum release of FU was obtained after 48 h.
33227334	7	45	theme	model	976:980	arg1	drug					982:985	an antitumor model drug	963:985	an antitumor model drug	963:985	Modified CS was preliminary checked for controlled release of 5-fluorouracil (FU), as an antitumor model drug, in aqueous media where the maximum release of FU was obtained after 48 h.
33227334	5	46	theme	highest	591:597	arg1	stability					607:615	the highest thermal stability	587:615	the highest thermal stability among CS/HA composites	587:638	The 20% HA modified CS showed the highest thermal stability among CS/HA composites while adding CNT to the matrix in CS/HA/CNT composites enhances their thermal stability.
33227334	6	47	theme	CS	753:754	arg1	Ability					729:735	Ability	729:735	Ability of the modified CS to uptake metal ions	729:775	Ability of the modified CS to uptake metal ions was investigated by using Cu(NO3)2 where CS/HA/CNT/GA showed higher metal ion uptake than CS/HA/GA.
33227334	8	48	from	ease	1085:1088	arg1	matrices					1129:1136	the investigated matrices	1112:1136	the investigated matrices which can be arranged in the order of P111F > P121F > P211F > P311F > P221F > P321F	1112:1220	This is concluding the ease of release of FU from the investigated matrices which can be arranged in the order of P111F > P121F > P211F > P311F > P221F > P321F.
33227334	3	49	theme	slight	414:419	arg1	loss					428:431	a slight weight loss	412:431	a slight weight loss	412:431	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	5	50	theme	thermal	599:605	arg1	stability					607:615	the highest thermal stability	587:615	the highest thermal stability among CS/HA composites	587:638	The 20% HA modified CS showed the highest thermal stability among CS/HA composites while adding CNT to the matrix in CS/HA/CNT composites enhances their thermal stability.
33227334	6	51	theme	modified	744:751	arg1	CS					753:754	the modified CS	740:754	the modified CS	740:754	Ability of the modified CS to uptake metal ions was investigated by using Cu(NO3)2 where CS/HA/CNT/GA showed higher metal ion uptake than CS/HA/GA.
33227334	3	52	dep	420 °C	401:406	arg1	up					395:396	up	395:396	up	395:396	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	7	53	theme	Modified	877:884	arg1	CS					886:887	Modified CS	877:887	Modified CS	877:887	Modified CS was preliminary checked for controlled release of 5-fluorouracil (FU), as an antitumor model drug, in aqueous media where the maximum release of FU was obtained after 48 h.
33227334	3	54	theme	weight	421:426	arg1	loss					428:431	a slight weight loss	412:431	a slight weight loss	412:431	The modified CS suffered a slight weight loss % up to 240 °C then extensive weight loss (EWL)% up to 420 °C and a slight weight loss again until the end of measurement at 700 °C.
33227334	4	55	theme	CS	535:536	arg1	stability					513:521	more thermal stability	500:521	more thermal stability of modified CS	500:536	The treatment showed more thermal stability of modified CS over the blank CS.
33227334	5	56	from	matrix	664:669	arg1	composites					684:693	CS/HA/CNT composites	674:693	CS/HA/CNT composites	674:693	The 20% HA modified CS showed the highest thermal stability among CS/HA composites while adding CNT to the matrix in CS/HA/CNT composites enhances their thermal stability.
33227334	2	57	theme	obtained	223:230	arg1	products					232:239	The obtained products	219:239	The obtained products	219:239	The obtained products were characterized and investigated with thermal analysis.
33227334	1	58	dep	modified	92:99	arg1	followed					168:175	followed	168:175	followed by crosslinking with glutaraldehyde (GA)	168:216	Chitosan (CS) was modified using hydroxyapatite (HA) and multiwalled carbon nanotubes (MWCNT) followed by crosslinking with glutaraldehyde (GA).
33227334	4	59	theme	blank	547:551	arg1	CS					553:554	the blank CS	543:554	the blank CS	543:554	The treatment showed more thermal stability of modified CS over the blank CS.
33227334	1	60	theme	multiwalled	131:141	arg1	MWCNT					161:165	MWCNT	161:165	MWCNT	161:165	Chitosan (CS) was modified using hydroxyapatite (HA) and multiwalled carbon nanotubes (MWCNT) followed by crosslinking with glutaraldehyde (GA).
33227334	1	60	theme	multiwalled	131:141	arg1	nanotubes					150:158	multiwalled carbon nanotubes	131:158	multiwalled carbon nanotubes (MWCNT)	131:166	Chitosan (CS) was modified using hydroxyapatite (HA) and multiwalled carbon nanotubes (MWCNT) followed by crosslinking with glutaraldehyde (GA).
33903946	2	0	theme	analysis	552:559	arg1	techniques					561:570	thermogravimetric analysis techniques	534:570	thermogravimetric analysis techniques	534:570	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	7	1	theme	important	1612:1620	arg1	role					1622:1625	an important role	1609:1625	an important role	1609:1625	Additionally, by the study of the molecular docking, hydrogen bonding and inclusion complexation were believed to play an important role in chiral recognition.
33903946	8	2	contain	have	1680:1683	arg2	material					1659:1666	a new material	1653:1666	a new material	1653:1666	As a new material, EDACD will have a wider application in the analysis of chiral compounds.
33903946	8	2	contain	have	1680:1683	arg2	application					1693:1703	a wider application	1685:1703	a wider application	1685:1703	As a new material, EDACD will have a wider application in the analysis of chiral compounds.
33903946	8	2	contain	have	1680:1683	arg1	EDACD					1669:1673	EDACD	1669:1673	EDACD	1669:1673	As a new material, EDACD will have a wider application in the analysis of chiral compounds.
33903946	1	3	theme	chiral	175:180	arg1	EDACD					200:204	EDACD	200:204	EDACD	200:204	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	1	3	theme	chiral	175:180	arg1	phase					193:197	chiral stationary phase	175:197	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD)	123:205	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	8	4	theme	new	1655:1657	arg1	material					1659:1666	a new material	1653:1666	a new material	1653:1666	As a new material, EDACD will have a wider application in the analysis of chiral compounds.
33903946	8	4	theme	new	1655:1657	arg1	application					1693:1703	a wider application	1685:1703	a wider application	1685:1703	As a new material, EDACD will have a wider application in the analysis of chiral compounds.
33903946	7	5	theme	hydrogen	1543:1550	arg1	bonding					1552:1558	hydrogen bonding	1543:1558	hydrogen bonding	1543:1558	Additionally, by the study of the molecular docking, hydrogen bonding and inclusion complexation were believed to play an important role in chiral recognition.
33903946	2	6	theme	thermogravimetric	534:550	arg1	techniques					561:570	thermogravimetric analysis techniques	534:570	thermogravimetric analysis techniques	534:570	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	3	7	theme	mobile	802:807	arg1	compositions					815:826	mobile phase compositions	802:826	mobile phase compositions	802:826	The factors that affected enantioseparation including mobile phase compositions and buffers were investigated in more detail.
33903946	5	8	theme	formate	1013:1019	arg1	phase					972:976	the mobile phase	961:976	the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1	961:1102	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	1	9	theme	stationary	182:191	arg1	EDACD					200:204	EDACD	200:204	EDACD	200:204	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	1	9	theme	stationary	182:191	arg1	phase					193:197	chiral stationary phase	175:197	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD)	123:205	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	6	10	theme	best	1455:1458	arg1	resolutions					1460:1470	the best resolutions	1451:1470	the best resolutions of 1.60 and 1.59	1451:1487	To adjust the proportion of acetonitrile to 80% (by volume), the enantiomers of pranoprofen and flurbiprofen were completely resolved with the best resolutions of 1.60 and 1.59.
33903946	1	11	theme	active	289:294	arg1	isocyanate					302:311	the active alkyl isocyanate	285:311	the active alkyl isocyanate	285:311	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	0	12	theme	docking	108:114	arg1	study					116:120	molecular docking study	98:120	molecular docking study	98:120	Enantioseparation on a new synthetic β-cyclodextrin chemically bonded chiral stationary phase and molecular docking study.
33903946	0	13	from	Enantioseparation	0:16	arg1	β-cyclodextrin					37:50	a new synthetic β-cyclodextrin	21:50	a new synthetic β-cyclodextrin	21:50	Enantioseparation on a new synthetic β-cyclodextrin chemically bonded chiral stationary phase and molecular docking study.
33903946	5	14	theme	ammonium	1004:1011	arg1	formate					1013:1019	20-mM ammonium formate	998:1019	20-mM ammonium formate	998:1019	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	1	15	theme	alkyl	296:300	arg1	isocyanate					302:311	the active alkyl isocyanate	285:311	the active alkyl isocyanate	285:311	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	0	16	theme	molecular	98:106	arg1	study					116:120	molecular docking study	98:120	molecular docking study	98:120	Enantioseparation on a new synthetic β-cyclodextrin chemically bonded chiral stationary phase and molecular docking study.
33903946	5	17	theme	ketoprofen	1168:1177	arg1	enantiomers					1109:1119	the enantiomers	1105:1119	the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin	1105:1214	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	2	18	theme	antiinflammatory	669:684	arg1	drugs					686:690	non-steroidal antiinflammatory drugs	655:690	non-steroidal antiinflammatory drugs	655:690	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	1	19	dep	derivative	146:155	arg1	EDACD					200:204	EDACD	200:204	EDACD	200:204	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	1	19	dep	derivative	146:155	arg1	phase					193:197	chiral stationary phase	175:197	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD)	123:205	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	2	20	theme	successful	349:358	arg1	analysis					360:367	the successful analysis	345:367	the successful analysis	345:367	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	2	21	theme	enantioselective	577:592	arg1	performance					594:604	the enantioselective performance	573:604	the enantioselective performance of the as-prepared EDACD column	573:636	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	2	22	theme	HPLC	732:735	arg1	condition					737:745	the reversed-phase HPLC condition	713:745	the reversed-phase HPLC condition	713:745	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	5	23	theme	acetonitrile	981:992	arg1	phase					972:976	the mobile phase	961:976	the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1	961:1102	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	2	24	theme	infrared	444:451	arg1	spectra					453:459	infrared spectra	444:459	infrared spectra	444:459	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	5	25	theme	eriocitrin	1180:1189	arg1	enantiomers					1109:1119	the enantiomers	1105:1119	the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin	1105:1214	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	2	26	theme	reversed-phase	717:730	arg1	condition					737:745	the reversed-phase HPLC condition	713:745	the reversed-phase HPLC condition	713:745	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	8	27	theme	wider	1687:1691	arg1	material					1659:1666	a new material	1653:1666	a new material	1653:1666	As a new material, EDACD will have a wider application in the analysis of chiral compounds.
33903946	8	27	theme	wider	1687:1691	arg1	application					1693:1703	a wider application	1685:1703	a wider application	1685:1703	As a new material, EDACD will have a wider application in the analysis of chiral compounds.
33903946	6	28	dep	adjust	1315:1320	arg1	volume					1364:1369	volume	1364:1369	volume	1364:1369	To adjust the proportion of acetonitrile to 80% (by volume), the enantiomers of pranoprofen and flurbiprofen were completely resolved with the best resolutions of 1.60 and 1.59.
33903946	5	29	theme	1.53	1260:1263	arg1	resolutions					1245:1255	the best resolutions	1236:1255	the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52	1236:1309	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	3	30	theme	phase	809:813	arg1	compositions					815:826	mobile phase compositions	802:826	mobile phase compositions	802:826	The factors that affected enantioseparation including mobile phase compositions and buffers were investigated in more detail.
33903946	6	31	theme	acetonitrile	1340:1351	arg1	proportion					1326:1335	the proportion	1322:1335	the proportion of acetonitrile to 80%	1322:1358	To adjust the proportion of acetonitrile to 80% (by volume), the enantiomers of pranoprofen and flurbiprofen were completely resolved with the best resolutions of 1.60 and 1.59.
33903946	5	32	theme	best	1240:1243	arg1	resolutions					1245:1255	the best resolutions	1236:1255	the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52	1236:1309	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	0	33	theme	new	23:25	arg1	β-cyclodextrin					37:50	a new synthetic β-cyclodextrin	21:50	a new synthetic β-cyclodextrin	21:50	Enantioseparation on a new synthetic β-cyclodextrin chemically bonded chiral stationary phase and molecular docking study.
33903946	7	34	theme	chiral	1630:1635	arg1	recognition					1637:1647	chiral recognition	1630:1647	chiral recognition	1630:1647	Additionally, by the study of the molecular docking, hydrogen bonding and inclusion complexation were believed to play an important role in chiral recognition.
33903946	2	35	theme	column	631:636	arg1	performance					594:604	the enantioselective performance	573:604	the enantioselective performance of the as-prepared EDACD column	573:636	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	5	36	theme	formic	1046:1051	arg1	85:15					1059:1063	85:15	1059:1063	85:15	1059:1063	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	5	36	theme	formic	1046:1051	arg1	acid					1053:1056	formic acid	1046:1056	formic acid (85:15, v/v)	1046:1069	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	2	37	theme	nuclear	474:480	arg1	spectra					501:507	solid-state nuclear magnetic resonance spectra	462:507	solid-state nuclear magnetic resonance spectra	462:507	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	2	38	theme	magnetic	482:489	arg1	spectra					501:507	solid-state nuclear magnetic resonance spectra	462:507	solid-state nuclear magnetic resonance spectra	462:507	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	3	39	theme	more	861:864	arg1	detail					866:871	more detail	861:871	more detail	861:871	The factors that affected enantioseparation including mobile phase compositions and buffers were investigated in more detail.
33903946	2	40	theme	EDACD	625:629	arg1	column					631:636	the as-prepared EDACD column	609:636	the as-prepared EDACD column	609:636	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	5	41	theme	naproxen	1146:1153	arg1	enantiomers					1109:1119	the enantiomers	1105:1119	the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin	1105:1214	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	2	42	theme	solid-state	462:472	arg1	spectra					501:507	solid-state nuclear magnetic resonance spectra	462:507	solid-state nuclear magnetic resonance spectra	462:507	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	6	43	theme	flurbiprofen	1408:1419	arg1	enantiomers					1377:1387	the enantiomers	1373:1387	the enantiomers of pranoprofen and flurbiprofen	1373:1419	To adjust the proportion of acetonitrile to 80% (by volume), the enantiomers of pranoprofen and flurbiprofen were completely resolved with the best resolutions of 1.60 and 1.59.
33903946	1	44	theme	silica	327:332	arg1	gel					334:336	silica gel	327:336	silica gel	327:336	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	2	45	theme	as-prepared	613:623	arg1	column					631:636	the as-prepared EDACD column	609:636	the as-prepared EDACD column	609:636	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	7	46	theme	molecular	1524:1532	arg1	docking					1534:1540	the molecular docking	1520:1540	the molecular docking	1520:1540	Additionally, by the study of the molecular docking, hydrogen bonding and inclusion complexation were believed to play an important role in chiral recognition.
33903946	0	47	theme	synthetic	27:35	arg1	β-cyclodextrin					37:50	a new synthetic β-cyclodextrin	21:50	a new synthetic β-cyclodextrin	21:50	Enantioseparation on a new synthetic β-cyclodextrin chemically bonded chiral stationary phase and molecular docking study.
33903946	5	48	theme	indoprofen	1156:1165	arg1	enantiomers					1109:1119	the enantiomers	1105:1119	the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin	1105:1214	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	2	49	theme	resonance	491:499	arg1	spectra					501:507	solid-state nuclear magnetic resonance spectra	462:507	solid-state nuclear magnetic resonance spectra	462:507	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	8	50	theme	chiral	1724:1729	arg1	compounds					1731:1739	chiral compounds	1724:1739	chiral compounds	1724:1739	As a new material, EDACD will have a wider application in the analysis of chiral compounds.
33903946	5	51	theme	mobile	965:970	arg1	phase					972:976	the mobile phase	961:976	the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1	961:1102	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	6	52	theme	pranoprofen	1392:1402	arg1	enantiomers					1377:1387	the enantiomers	1373:1387	the enantiomers of pranoprofen and flurbiprofen	1373:1419	To adjust the proportion of acetonitrile to 80% (by volume), the enantiomers of pranoprofen and flurbiprofen were completely resolved with the best resolutions of 1.60 and 1.59.
33903946	5	53	theme	20-mM	998:1002	arg1	formate					1013:1019	20-mM ammonium formate	998:1019	20-mM ammonium formate	998:1019	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	2	54	theme	non-steroidal	655:667	arg1	drugs					686:690	non-steroidal antiinflammatory drugs	655:690	non-steroidal antiinflammatory drugs	655:690	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	7	55	theme	docking	1534:1540	arg1	study					1511:1515	the study	1507:1515	the study of the molecular docking	1507:1540	Additionally, by the study of the molecular docking, hydrogen bonding and inclusion complexation were believed to play an important role in chiral recognition.
33903946	2	56	theme	elemental	510:518	arg1	analysis					520:527	elemental analysis	510:527	elemental analysis	510:527	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	5	57	theme	ibuprofen	1124:1132	arg1	enantiomers					1109:1119	the enantiomers	1105:1119	the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin	1105:1214	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	4	58	theme	tested	942:947	arg1	drugs					949:953	the tested drugs	938:953	the tested drugs	938:953	As a result, EDACD showed a satisfactory enantioselectivity for the tested drugs.
33903946	1	59	theme	novel	125:129	arg1	derivative					146:155	A novel β-cyclodextrin derivative	123:155	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD)	123:205	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	5	60	theme	0.6 mL min-1	1091:1102	arg1	rate					1083:1086	the flow rate	1074:1086	the flow rate of 0.6 mL min-1	1074:1102	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	5	61	theme	flow	1078:1081	arg1	rate					1083:1086	the flow rate	1074:1086	the flow rate of 0.6 mL min-1	1074:1102	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	2	62	dep	Fourier	426:432	arg1	transform					434:442	transform	434:442	transform infrared spectra	434:459	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	8	63	theme	compounds	1731:1739	arg1	analysis					1712:1719	the analysis	1708:1719	the analysis of chiral compounds	1708:1739	As a new material, EDACD will have a wider application in the analysis of chiral compounds.
33903946	1	64	theme	β-cyclodextrin	131:144	arg1	derivative					146:155	A novel β-cyclodextrin derivative	123:155	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD)	123:205	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	6	65	theme	1.59	1484:1487	arg1	resolutions					1460:1470	the best resolutions	1451:1470	the best resolutions of 1.60 and 1.59	1451:1487	To adjust the proportion of acetonitrile to 80% (by volume), the enantiomers of pranoprofen and flurbiprofen were completely resolved with the best resolutions of 1.60 and 1.59.
33903946	5	66	theme	carprofen	1135:1143	arg1	enantiomers					1109:1119	the enantiomers	1105:1119	the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin	1105:1214	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	5	67	dep	85:15	1059:1063	arg1	v/v					1066:1068	v/v	1066:1068	v/v	1066:1068	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	1	68	theme	bonded	168:173	arg1	derivative					146:155	A novel β-cyclodextrin derivative	123:155	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD)	123:205	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	0	69	theme	stationary	77:86	arg1	phase					88:92	chiral stationary phase	70:92	chiral stationary phase	70:92	Enantioseparation on a new synthetic β-cyclodextrin chemically bonded chiral stationary phase and molecular docking study.
33903946	5	70	theme	narirutin	1206:1214	arg1	enantiomers					1109:1119	the enantiomers	1105:1119	the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin	1105:1214	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	2	71	theme	scanning	396:403	arg1	microscopy					414:423	scanning electron microscopy	396:423	scanning electron microscopy	396:423	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	6	72	theme	1.60	1475:1478	arg1	resolutions					1460:1470	the best resolutions	1451:1470	the best resolutions of 1.60 and 1.59	1451:1487	To adjust the proportion of acetonitrile to 80% (by volume), the enantiomers of pranoprofen and flurbiprofen were completely resolved with the best resolutions of 1.60 and 1.59.
33903946	1	73	theme	mono-6-ethylenediamine-β-cyclodextrin	242:278	arg1	reaction					230:237	the reaction	226:237	the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel	226:336	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	0	74	theme	chiral	70:75	arg1	phase					88:92	chiral stationary phase	70:92	chiral stationary phase	70:92	Enantioseparation on a new synthetic β-cyclodextrin chemically bonded chiral stationary phase and molecular docking study.
33903946	5	75	theme	naringin	1192:1199	arg1	enantiomers					1109:1119	the enantiomers	1105:1119	the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin	1105:1214	With the mobile phase of acetonitrile and 20-mM ammonium formate adjusted to pH 4.0 using formic acid (85:15, v/v) at the flow rate of 0.6 mL min-1, the enantiomers of ibuprofen, carprofen, naproxen, indoprofen, ketoprofen, eriocitrin, naringin, and narirutin were separated with the best resolutions of 1.53, 1.64, 3.72, 2.40, 0.50, 0.61, 0.58, and 0.52.
33903946	4	76	theme	satisfactory	902:913	arg1	result					879:884	a result	877:884	a result	877:884	As a result, EDACD showed a satisfactory enantioselectivity for the tested drugs.
33903946	4	76	theme	satisfactory	902:913	arg1	enantioselectivity					915:932	a satisfactory enantioselectivity	900:932	a satisfactory enantioselectivity for the tested drugs	900:953	As a result, EDACD showed a satisfactory enantioselectivity for the tested drugs.
33903946	1	77	with	reaction	230:237	arg1	isocyanate					302:311	the active alkyl isocyanate	285:311	the active alkyl isocyanate	285:311	A novel β-cyclodextrin derivative chemically bonded chiral stationary phase (EDACD) was synthesized by the reaction of mono-6-ethylenediamine-β-cyclodextrin with the active alkyl isocyanate, anchoring to silica gel.
33903946	2	78	theme	electron	405:412	arg1	microscopy					414:423	scanning electron microscopy	396:423	scanning electron microscopy	396:423	After the successful analysis and characterization using scanning electron microscopy, Fourier transform infrared spectra, solid-state nuclear magnetic resonance spectra, elemental analysis, and thermogravimetric analysis techniques, the enantioselective performance of the as-prepared EDACD column was evaluated by non-steroidal antiinflammatory drugs and flavonoids under the reversed-phase HPLC condition.
33903946	7	79	theme	inclusion	1564:1572	arg1	complexation					1574:1585	inclusion complexation	1564:1585	inclusion complexation	1564:1585	Additionally, by the study of the molecular docking, hydrogen bonding and inclusion complexation were believed to play an important role in chiral recognition.
32562253	0	0	theme	inhalable	65:73	arg1	therapy					88:94	inhalable tuberculosis therapy	65:94	inhalable tuberculosis therapy targeting the macrophages	65:120	Carrageenan from red algae: an application in the development of inhalable tuberculosis therapy targeting the macrophages.
32562253	3	1	theme	alveolar	699:706	arg1	macrophages					708:718	directly targeting alveolar macrophages	680:718	directly targeting alveolar macrophages	680:718	Carrageenan (CRG), a polysaccharide extracted from red edible seaweed, is an interesting possibility for the approach of directly targeting alveolar macrophages, as its composition is reported to be recognized by several macrophage lectin receptors.
32562253	8	2	theme	dose-dependent	1565:1578	arg1	manner					1580:1585	a dose-dependent manner	1563:1585	a dose-dependent manner	1563:1585	Starch/CRG microparticles also exhibited a propensity to be captured by macrophages in a dose-dependent manner, as well as an ability to activate the target cells.
32562253	8	3	theme	Starch/CRG	1476:1485	arg1	microparticles					1487:1500	Starch/CRG microparticles	1476:1500	Starch/CRG microparticles	1476:1500	Starch/CRG microparticles also exhibited a propensity to be captured by macrophages in a dose-dependent manner, as well as an ability to activate the target cells.
32562253	7	4	theme	mild	1375:1378	arg1	toxicity					1380:1387	mild toxicity	1375:1387	mild toxicity	1375:1387	The formulation evidenced no cytotoxic effects on lung epithelial cells (A549), although mild toxicity was observed on macrophage-differentiated THP-1 cells for the drug-loaded formulation.
32562253	10	5	theme	drug	1930:1933	arg1	microparticles					1890:1903	these microparticles	1884:1903	these microparticles	1884:1903	Additionally, if tuberculosis is focused, these microparticles can be used as inhalable drug carriers.
32562253	10	5	theme	drug	1930:1933	arg1	carriers					1935:1942	inhalable drug carriers	1920:1942	inhalable drug carriers	1920:1942	Additionally, if tuberculosis is focused, these microparticles can be used as inhalable drug carriers.
32562253	7	6	located	observed	1393:1400	arg1	cells					1437:1441	macrophage-differentiated THP-1 cells	1405:1441	macrophage-differentiated THP-1 cells for the drug-loaded formulation	1405:1473	The formulation evidenced no cytotoxic effects on lung epithelial cells (A549), although mild toxicity was observed on macrophage-differentiated THP-1 cells for the drug-loaded formulation.
32562253	7	6	located	observed	1393:1400	arg2	toxicity					1380:1387	mild toxicity	1375:1387	mild toxicity	1375:1387	The formulation evidenced no cytotoxic effects on lung epithelial cells (A549), although mild toxicity was observed on macrophage-differentiated THP-1 cells for the drug-loaded formulation.
32562253	0	7	theme	therapy	88:94	arg1	development					50:60	the development	46:60	the development of inhalable tuberculosis therapy targeting the macrophages	46:120	Carrageenan from red algae: an application in the development of inhalable tuberculosis therapy targeting the macrophages.
32562253	6	8	theme	antitubercular	1209:1222	arg1	activity					1224:1231	the antitubercular activity	1205:1231	the antitubercular activity of the drugs	1205:1244	It was further demonstrated that the antitubercular activity of the drugs remained unchanged after encapsulation.
32562253	0	9	theme	tuberculosis	75:86	arg1	therapy					88:94	inhalable tuberculosis therapy	65:94	inhalable tuberculosis therapy targeting the macrophages	65:120	Carrageenan from red algae: an application in the development of inhalable tuberculosis therapy targeting the macrophages.
32562253	5	10	theme	mass	1108:1111	arg1	MMAD					1142:1145	MMAD	1142:1145	MMAD	1142:1145	Furthermore, the produced microparticles presented adequate aerodynamic properties for pulmonary delivery with potential to reach the respiratory zone, with a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm.
32562253	5	10	theme	mass	1108:1111	arg1	diameter					1132:1139	a mass median aerodynamic diameter	1106:1139	a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm	1106:1169	Furthermore, the produced microparticles presented adequate aerodynamic properties for pulmonary delivery with potential to reach the respiratory zone, with a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm.
32562253	7	11	from	effects	1325:1331	arg1	cells					1352:1356	lung epithelial cells	1336:1356	lung epithelial cells (A549)	1336:1363	The formulation evidenced no cytotoxic effects on lung epithelial cells (A549), although mild toxicity was observed on macrophage-differentiated THP-1 cells for the drug-loaded formulation.
32562253	7	11	from	effects	1325:1331	arg1	A549					1359:1362	A549	1359:1362	A549	1359:1362	The formulation evidenced no cytotoxic effects on lung epithelial cells (A549), although mild toxicity was observed on macrophage-differentiated THP-1 cells for the drug-loaded formulation.
32562253	5	12	theme	produced	966:973	arg1	microparticles					975:988	the produced microparticles	962:988	the produced microparticles	962:988	Furthermore, the produced microparticles presented adequate aerodynamic properties for pulmonary delivery with potential to reach the respiratory zone, with a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm.
32562253	9	13	from	indications	1659:1669	arg1	potential					1678:1686	the potential	1674:1686	the potential of the starch/CRG carriers to interact with macrophages	1674:1742	This work provides indications on the potential of the starch/CRG carriers to interact with macrophages, thus providing a platform for drug delivery in the context of macrophage intracellular diseases.
32562253	2	14	theme	recognition	510:520	arg1	pathways					522:529	the same recognition pathways	501:529	the same recognition pathways of the infecting organisms	501:556	Benefiting from a similar composition regarding the referred moieties, polysaccharides might be good candidates to compose the matrix of drug carriers aimed at macrophage targeting, as they can use the same recognition pathways of the infecting organisms.
32562253	0	15	from	application	31:41	arg1	development					50:60	the development	46:60	the development of inhalable tuberculosis therapy targeting the macrophages	46:120	Carrageenan from red algae: an application in the development of inhalable tuberculosis therapy targeting the macrophages.
32562253	9	16	theme	starch/CRG	1695:1704	arg1	carriers					1706:1713	the starch/CRG carriers	1691:1713	the starch/CRG carriers	1691:1713	This work provides indications on the potential of the starch/CRG carriers to interact with macrophages, thus providing a platform for drug delivery in the context of macrophage intracellular diseases.
32562253	7	17	theme	lung	1336:1339	arg1	cells					1352:1356	lung epithelial cells	1336:1356	lung epithelial cells (A549)	1336:1363	The formulation evidenced no cytotoxic effects on lung epithelial cells (A549), although mild toxicity was observed on macrophage-differentiated THP-1 cells for the drug-loaded formulation.
32562253	7	17	theme	lung	1336:1339	arg1	A549					1359:1362	A549	1359:1362	A549	1359:1362	The formulation evidenced no cytotoxic effects on lung epithelial cells (A549), although mild toxicity was observed on macrophage-differentiated THP-1 cells for the drug-loaded formulation.
32562253	7	18	theme	epithelial	1341:1350	arg1	cells					1352:1356	lung epithelial cells	1336:1356	lung epithelial cells (A549)	1336:1363	The formulation evidenced no cytotoxic effects on lung epithelial cells (A549), although mild toxicity was observed on macrophage-differentiated THP-1 cells for the drug-loaded formulation.
32562253	7	18	theme	epithelial	1341:1350	arg1	A549					1359:1362	A549	1359:1362	A549	1359:1362	The formulation evidenced no cytotoxic effects on lung epithelial cells (A549), although mild toxicity was observed on macrophage-differentiated THP-1 cells for the drug-loaded formulation.
32562253	2	19	theme	same	505:508	arg1	pathways					522:529	the same recognition pathways	501:529	the same recognition pathways of the infecting organisms	501:556	Benefiting from a similar composition regarding the referred moieties, polysaccharides might be good candidates to compose the matrix of drug carriers aimed at macrophage targeting, as they can use the same recognition pathways of the infecting organisms.
32562253	3	20	theme	macrophages	708:718	arg1	Carrageenan					559:569	Carrageenan	559:569	Carrageenan (CRG)	559:575	Carrageenan (CRG), a polysaccharide extracted from red edible seaweed, is an interesting possibility for the approach of directly targeting alveolar macrophages, as its composition is reported to be recognized by several macrophage lectin receptors.
32562253	3	20	theme	macrophages	708:718	arg1	possibility					648:658	an interesting possibility	633:658	an interesting possibility for the approach of directly targeting alveolar macrophages	633:718	Carrageenan (CRG), a polysaccharide extracted from red edible seaweed, is an interesting possibility for the approach of directly targeting alveolar macrophages, as its composition is reported to be recognized by several macrophage lectin receptors.
32562253	9	21	theme	carriers	1706:1713	arg1	potential					1678:1686	the potential	1674:1686	the potential of the starch/CRG carriers to interact with macrophages	1674:1742	This work provides indications on the potential of the starch/CRG carriers to interact with macrophages, thus providing a platform for drug delivery in the context of macrophage intracellular diseases.
32562253	7	22	theme	drug-loaded	1451:1461	arg1	formulation					1463:1473	the drug-loaded formulation	1447:1473	the drug-loaded formulation	1447:1473	The formulation evidenced no cytotoxic effects on lung epithelial cells (A549), although mild toxicity was observed on macrophage-differentiated THP-1 cells for the drug-loaded formulation.
32562253	5	23	dep	potential	1060:1068	arg1	reach					1073:1077	reach	1073:1077	to reach the respiratory zone	1070:1098	Furthermore, the produced microparticles presented adequate aerodynamic properties for pulmonary delivery with potential to reach the respiratory zone, with a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm.
32562253	9	24	theme	diseases	1832:1839	arg1	context					1796:1802	the context	1792:1802	the context of macrophage intracellular diseases	1792:1839	This work provides indications on the potential of the starch/CRG carriers to interact with macrophages, thus providing a platform for drug delivery in the context of macrophage intracellular diseases.
32562253	2	25	theme	similar	321:327	arg1	composition					329:339	a similar composition	319:339	a similar composition regarding the referred moieties	319:371	Benefiting from a similar composition regarding the referred moieties, polysaccharides might be good candidates to compose the matrix of drug carriers aimed at macrophage targeting, as they can use the same recognition pathways of the infecting organisms.
32562253	5	26	theme	median	1113:1118	arg1	MMAD					1142:1145	MMAD	1142:1145	MMAD	1142:1145	Furthermore, the produced microparticles presented adequate aerodynamic properties for pulmonary delivery with potential to reach the respiratory zone, with a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm.
32562253	5	26	theme	median	1113:1118	arg1	diameter					1132:1139	a mass median aerodynamic diameter	1106:1139	a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm	1106:1169	Furthermore, the produced microparticles presented adequate aerodynamic properties for pulmonary delivery with potential to reach the respiratory zone, with a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm.
32562253	2	27	theme	good	399:402	arg1	candidates					404:413	good candidates	399:413	good candidates	399:413	Benefiting from a similar composition regarding the referred moieties, polysaccharides might be good candidates to compose the matrix of drug carriers aimed at macrophage targeting, as they can use the same recognition pathways of the infecting organisms.
32562253	1	28	theme	bacterial	282:290	arg1	wall					297:300	the bacterial cell wall	278:300	the bacterial cell wall	278:300	Macrophages have unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms, including in the bacterial cell wall.
32562253	10	29	theme	inhalable	1920:1928	arg1	microparticles					1890:1903	these microparticles	1884:1903	these microparticles	1884:1903	Additionally, if tuberculosis is focused, these microparticles can be used as inhalable drug carriers.
32562253	10	29	theme	inhalable	1920:1928	arg1	carriers					1935:1942	inhalable drug carriers	1920:1942	inhalable drug carriers	1920:1942	Additionally, if tuberculosis is focused, these microparticles can be used as inhalable drug carriers.
32562253	1	30	theme	several	201:207	arg1	moieties					209:216	several moieties	201:216	several moieties present on the surface of infecting organisms	201:262	Macrophages have unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms, including in the bacterial cell wall.
32562253	2	31	theme	carriers	445:452	arg1	matrix					430:435	the matrix	426:435	the matrix of drug carriers aimed at macrophage targeting	426:482	Benefiting from a similar composition regarding the referred moieties, polysaccharides might be good candidates to compose the matrix of drug carriers aimed at macrophage targeting, as they can use the same recognition pathways of the infecting organisms.
32562253	1	32	theme	cell	292:295	arg1	wall					297:300	the bacterial cell wall	278:300	the bacterial cell wall	278:300	Macrophages have unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms, including in the bacterial cell wall.
32562253	7	33	theme	macrophage-differentiated	1405:1429	arg1	cells					1437:1441	macrophage-differentiated THP-1 cells	1405:1441	macrophage-differentiated THP-1 cells for the drug-loaded formulation	1405:1473	The formulation evidenced no cytotoxic effects on lung epithelial cells (A549), although mild toxicity was observed on macrophage-differentiated THP-1 cells for the drug-loaded formulation.
32562253	5	34	theme	pulmonary	1036:1044	arg1	delivery					1046:1053	pulmonary delivery	1036:1053	pulmonary delivery	1036:1053	Furthermore, the produced microparticles presented adequate aerodynamic properties for pulmonary delivery with potential to reach the respiratory zone, with a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm.
32562253	2	35	theme	drug	440:443	arg1	carriers					445:452	drug carriers	440:452	drug carriers aimed at macrophage targeting	440:482	Benefiting from a similar composition regarding the referred moieties, polysaccharides might be good candidates to compose the matrix of drug carriers aimed at macrophage targeting, as they can use the same recognition pathways of the infecting organisms.
32562253	2	36	theme	organisms	548:556	arg1	pathways					522:529	the same recognition pathways	501:529	the same recognition pathways of the infecting organisms	501:556	Benefiting from a similar composition regarding the referred moieties, polysaccharides might be good candidates to compose the matrix of drug carriers aimed at macrophage targeting, as they can use the same recognition pathways of the infecting organisms.
32562253	7	37	theme	THP-1	1431:1435	arg1	cells					1437:1441	macrophage-differentiated THP-1 cells	1405:1441	macrophage-differentiated THP-1 cells for the drug-loaded formulation	1405:1473	The formulation evidenced no cytotoxic effects on lung epithelial cells (A549), although mild toxicity was observed on macrophage-differentiated THP-1 cells for the drug-loaded formulation.
32562253	1	38	theme	present	218:224	arg1	moieties					209:216	several moieties	201:216	several moieties present on the surface of infecting organisms	201:262	Macrophages have unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms, including in the bacterial cell wall.
32562253	2	39	theme	infecting	538:546	arg1	organisms					548:556	the infecting organisms	534:556	the infecting organisms	534:556	Benefiting from a similar composition regarding the referred moieties, polysaccharides might be good candidates to compose the matrix of drug carriers aimed at macrophage targeting, as they can use the same recognition pathways of the infecting organisms.
32562253	3	40	theme	interesting	636:646	arg1	Carrageenan					559:569	Carrageenan	559:569	Carrageenan (CRG)	559:575	Carrageenan (CRG), a polysaccharide extracted from red edible seaweed, is an interesting possibility for the approach of directly targeting alveolar macrophages, as its composition is reported to be recognized by several macrophage lectin receptors.
32562253	3	40	theme	interesting	636:646	arg1	possibility					648:658	an interesting possibility	633:658	an interesting possibility for the approach of directly targeting alveolar macrophages	633:718	Carrageenan (CRG), a polysaccharide extracted from red edible seaweed, is an interesting possibility for the approach of directly targeting alveolar macrophages, as its composition is reported to be recognized by several macrophage lectin receptors.
32562253	4	41	theme	starch/CRG	819:828	arg1	microparticles					830:843	Inhalable starch/CRG microparticles	809:843	Inhalable starch/CRG microparticles	809:843	Inhalable starch/CRG microparticles were successfully produced, effectively associating isoniazid (96%) and rifabutin (74%) simultaneously.
32562253	7	42	theme	cytotoxic	1315:1323	arg1	effects					1325:1331	no cytotoxic effects	1312:1331	no cytotoxic effects on lung epithelial cells (A549)	1312:1363	The formulation evidenced no cytotoxic effects on lung epithelial cells (A549), although mild toxicity was observed on macrophage-differentiated THP-1 cells for the drug-loaded formulation.
32562253	0	43	theme	red	17:19	arg1	algae					21:25	red algae	17:25	red algae	17:25	Carrageenan from red algae: an application in the development of inhalable tuberculosis therapy targeting the macrophages.
32562253	3	44	theme	macrophage	780:789	arg1	receptors					798:806	several macrophage lectin receptors	772:806	several macrophage lectin receptors	772:806	Carrageenan (CRG), a polysaccharide extracted from red edible seaweed, is an interesting possibility for the approach of directly targeting alveolar macrophages, as its composition is reported to be recognized by several macrophage lectin receptors.
32562253	9	45	theme	macrophage	1807:1816	arg1	diseases					1832:1839	macrophage intracellular diseases	1807:1839	macrophage intracellular diseases	1807:1839	This work provides indications on the potential of the starch/CRG carriers to interact with macrophages, thus providing a platform for drug delivery in the context of macrophage intracellular diseases.
32562253	3	46	theme	lectin	791:796	arg1	receptors					798:806	several macrophage lectin receptors	772:806	several macrophage lectin receptors	772:806	Carrageenan (CRG), a polysaccharide extracted from red edible seaweed, is an interesting possibility for the approach of directly targeting alveolar macrophages, as its composition is reported to be recognized by several macrophage lectin receptors.
32562253	3	47	theme	several	772:778	arg1	receptors					798:806	several macrophage lectin receptors	772:806	several macrophage lectin receptors	772:806	Carrageenan (CRG), a polysaccharide extracted from red edible seaweed, is an interesting possibility for the approach of directly targeting alveolar macrophages, as its composition is reported to be recognized by several macrophage lectin receptors.
32562253	10	48	used	used	1912:1915	arg2	carriers					1935:1942	inhalable drug carriers	1920:1942	inhalable drug carriers	1920:1942	Additionally, if tuberculosis is focused, these microparticles can be used as inhalable drug carriers.
32562253	10	48	used	used	1912:1915	arg2	microparticles					1890:1903	these microparticles	1884:1903	these microparticles	1884:1903	Additionally, if tuberculosis is focused, these microparticles can be used as inhalable drug carriers.
32562253	5	49	theme	aerodynamic	1120:1130	arg1	MMAD					1142:1145	MMAD	1142:1145	MMAD	1142:1145	Furthermore, the produced microparticles presented adequate aerodynamic properties for pulmonary delivery with potential to reach the respiratory zone, with a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm.
32562253	5	49	theme	aerodynamic	1120:1130	arg1	diameter					1132:1139	a mass median aerodynamic diameter	1106:1139	a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm	1106:1169	Furthermore, the produced microparticles presented adequate aerodynamic properties for pulmonary delivery with potential to reach the respiratory zone, with a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm.
32562253	2	50	theme	referred	355:362	arg1	moieties					364:371	the referred moieties	351:371	the referred moieties	351:371	Benefiting from a similar composition regarding the referred moieties, polysaccharides might be good candidates to compose the matrix of drug carriers aimed at macrophage targeting, as they can use the same recognition pathways of the infecting organisms.
32562253	2	51	theme	macrophage	463:472	arg1	targeting					474:482	macrophage targeting	463:482	macrophage targeting	463:482	Benefiting from a similar composition regarding the referred moieties, polysaccharides might be good candidates to compose the matrix of drug carriers aimed at macrophage targeting, as they can use the same recognition pathways of the infecting organisms.
32562253	6	52	theme	drugs	1240:1244	arg1	activity					1224:1231	the antitubercular activity	1205:1231	the antitubercular activity of the drugs	1205:1244	It was further demonstrated that the antitubercular activity of the drugs remained unchanged after encapsulation.
32562253	0	53	from	algae	21:25	arg1	Carrageenan					0:10	Carrageenan	0:10	Carrageenan from red algae: an application in the development of inhalable tuberculosis therapy targeting the macrophages.	0:121	Carrageenan from red algae: an application in the development of inhalable tuberculosis therapy targeting the macrophages.
32562253	1	54	attach	present	218:224	arg1	surface					233:239	the surface	229:239	the surface of infecting organisms	229:262	Macrophages have unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms, including in the bacterial cell wall.
32562253	1	54	attach	present	218:224	arg2	moieties					209:216	several moieties	201:216	several moieties present on the surface of infecting organisms	201:262	Macrophages have unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms, including in the bacterial cell wall.
32562253	9	55	theme	intracellular	1818:1830	arg1	diseases					1832:1839	macrophage intracellular diseases	1807:1839	macrophage intracellular diseases	1807:1839	This work provides indications on the potential of the starch/CRG carriers to interact with macrophages, thus providing a platform for drug delivery in the context of macrophage intracellular diseases.
32562253	3	56	theme	targeting	689:697	arg1	macrophages					708:718	directly targeting alveolar macrophages	680:718	directly targeting alveolar macrophages	680:718	Carrageenan (CRG), a polysaccharide extracted from red edible seaweed, is an interesting possibility for the approach of directly targeting alveolar macrophages, as its composition is reported to be recognized by several macrophage lectin receptors.
32562253	3	57	theme	red	610:612	arg1	seaweed					621:627	red edible seaweed	610:627	red edible seaweed	610:627	Carrageenan (CRG), a polysaccharide extracted from red edible seaweed, is an interesting possibility for the approach of directly targeting alveolar macrophages, as its composition is reported to be recognized by several macrophage lectin receptors.
32562253	5	58	theme	adequate	1000:1007	arg1	properties					1021:1030	adequate aerodynamic properties	1000:1030	adequate aerodynamic properties for pulmonary delivery	1000:1053	Furthermore, the produced microparticles presented adequate aerodynamic properties for pulmonary delivery with potential to reach the respiratory zone, with a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm.
32562253	3	59	theme	edible	614:619	arg1	seaweed					621:627	red edible seaweed	610:627	red edible seaweed	610:627	Carrageenan (CRG), a polysaccharide extracted from red edible seaweed, is an interesting possibility for the approach of directly targeting alveolar macrophages, as its composition is reported to be recognized by several macrophage lectin receptors.
32562253	4	60	theme	Inhalable	809:817	arg1	microparticles					830:843	Inhalable starch/CRG microparticles	809:843	Inhalable starch/CRG microparticles	809:843	Inhalable starch/CRG microparticles were successfully produced, effectively associating isoniazid (96%) and rifabutin (74%) simultaneously.
32562253	5	61	theme	aerodynamic	1009:1019	arg1	properties					1021:1030	adequate aerodynamic properties	1000:1030	adequate aerodynamic properties for pulmonary delivery	1000:1053	Furthermore, the produced microparticles presented adequate aerodynamic properties for pulmonary delivery with potential to reach the respiratory zone, with a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm.
32562253	8	62	theme	target	1626:1631	arg1	cells					1633:1637	the target cells	1622:1637	the target cells	1622:1637	Starch/CRG microparticles also exhibited a propensity to be captured by macrophages in a dose-dependent manner, as well as an ability to activate the target cells.
32562253	9	63	theme	drug	1775:1778	arg1	delivery					1780:1787	drug delivery	1775:1787	drug delivery	1775:1787	This work provides indications on the potential of the starch/CRG carriers to interact with macrophages, thus providing a platform for drug delivery in the context of macrophage intracellular diseases.
32562253	5	64	theme	respiratory	1083:1093	arg1	zone					1095:1098	the respiratory zone	1079:1098	the respiratory zone	1079:1098	Furthermore, the produced microparticles presented adequate aerodynamic properties for pulmonary delivery with potential to reach the respiratory zone, with a mass median aerodynamic diameter (MMAD) between 3.3 and 3.9 μm.
32562253	1	65	theme	unique	140:145	arg1	receptors					155:163	unique surface receptors	140:163	unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms	140:262	Macrophages have unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms, including in the bacterial cell wall.
32562253	11	66	theme	Graphical	1945:1953	arg1	abstractz					1955:1963	Graphical abstractz	1945:1963	Graphical abstractz.	1945:1964	Graphical abstractz.
32562253	1	67	theme	infecting	244:252	arg1	organisms					254:262	infecting organisms	244:262	infecting organisms	244:262	Macrophages have unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms, including in the bacterial cell wall.
32562253	1	68	contain	have	135:138	arg1	Macrophages					123:133	Macrophages	123:133	Macrophages	123:133	Macrophages have unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms, including in the bacterial cell wall.
32562253	1	68	contain	have	135:138	arg2	receptors					155:163	unique surface receptors	140:163	unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms	140:262	Macrophages have unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms, including in the bacterial cell wall.
32562253	0	69	dep	Carrageenan	0:10	arg1	application					31:41	an application	28:41	Carrageenan from red algae: an application in the development of inhalable tuberculosis therapy targeting the macrophages.	0:121	Carrageenan from red algae: an application in the development of inhalable tuberculosis therapy targeting the macrophages.
32562253	1	70	theme	surface	147:153	arg1	receptors					155:163	unique surface receptors	140:163	unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms	140:262	Macrophages have unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms, including in the bacterial cell wall.
32562253	1	71	theme	organisms	254:262	arg1	surface					233:239	the surface	229:239	the surface of infecting organisms	229:262	Macrophages have unique surface receptors that might recognize preferentially several moieties present on the surface of infecting organisms, including in the bacterial cell wall.
33128276	0	0	from	Structures	19:28	arg1	Foraminifera					48:59	Foraminifera	48:59	Foraminifera	48:59	Abundant Chitinous Structures in Chilostomella (Foraminifera, Rhizaria) and Their Potential Functions.
33128276	0	0	from	Structures	19:28	arg1	Chilostomella					33:45	Chilostomella	33:45	Chilostomella	33:45	Abundant Chitinous Structures in Chilostomella (Foraminifera, Rhizaria) and Their Potential Functions.
33128276	10	1	theme	surface/volume	1526:1539	arg1	ratio					1541:1545	the surface/volume ratio	1522:1545	the surface/volume ratio	1522:1545	These chitinous, plate-like structures may function to partition the cytoplasm in a chamber to increase the surface/volume ratio and/or act as a reactive site for some metabolic functions.
33128276	8	2	theme	chitinous	1240:1248	arg1	structures					1250:1259	chitinous structures	1240:1259	chitinous structures	1240:1259	Our 3D reconstruction revealed chitinous structures in the final seven chambers.
33128276	5	3	from	features	765:772	arg1	sediments					812:820	bathyal sediments	804:820	bathyal sediments of Sagami Bay, Japan	804:841	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	4	4	from	genera	644:649	arg1	compositions					563:574	the carbon isotopic compositions	543:574	the carbon isotopic compositions of their lipids	543:590	For example, the carbon isotopic compositions of their lipids are substantially different from other co-occurring genera, probably reflecting unique features of its metabolism.
33128276	4	4	from	genera	644:649	arg1	different					610:618	different	610:618	different	610:618	For example, the carbon isotopic compositions of their lipids are substantially different from other co-occurring genera, probably reflecting unique features of its metabolism.
33128276	9	5	theme	earlier	1376:1382	arg1	chambers					1384:1391	earlier chambers	1376:1391	earlier chambers	1376:1391	These exhibited a plate-like morphology in the final chambers but became rolled up in earlier chambers (toward the proloculus).
33128276	5	6	from	sediments	812:820	arg1	features					765:772	the cytoplasmic and ultrastructural features	729:772	the cytoplasmic and ultrastructural features	729:772	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	5	6	from	sediments	812:820	arg1	ovoidea					791:797	Chilostomella ovoidea	777:797	Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan	777:841	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	9	7	theme	final	1337:1341	arg1	chambers					1343:1350	the final chambers	1333:1350	the final chambers	1333:1350	These exhibited a plate-like morphology in the final chambers but became rolled up in earlier chambers (toward the proloculus).
33128276	6	8	theme	abundant	1064:1071	arg1	structures					1088:1097	abundant electron-dense structures	1064:1097	abundant electron-dense structures dividing the cytoplasm	1064:1120	Observations by TEM revealed the presence of abundant electron-dense structures dividing the cytoplasm.
33128276	5	9	theme	Chilostomella	777:789	arg1	ovoidea					791:797	Chilostomella ovoidea	777:797	Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan	777:841	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	4	10	theme	co-occurring	631:642	arg1	genera					644:649	other co-occurring genera	625:649	other co-occurring genera	625:649	For example, the carbon isotopic compositions of their lipids are substantially different from other co-occurring genera, probably reflecting unique features of its metabolism.
33128276	0	11	theme	Potential	82:90	arg1	Functions					92:100	Their Potential Functions	76:100	Their Potential Functions	76:100	Abundant Chitinous Structures in Chilostomella (Foraminifera, Rhizaria) and Their Potential Functions.
33128276	4	12	theme	other	625:629	arg1	genera					644:649	other co-occurring genera	625:649	other co-occurring genera	625:649	For example, the carbon isotopic compositions of their lipids are substantially different from other co-occurring genera, probably reflecting unique features of its metabolism.
33128276	4	13	theme	unique	672:677	arg1	features					679:686	unique features	672:686	unique features of its metabolism	672:704	For example, the carbon isotopic compositions of their lipids are substantially different from other co-occurring genera, probably reflecting unique features of its metabolism.
33128276	2	14	theme	foraminifera	264:275	arg1	key					280:282	key	280:282	key	280:282	The biology of benthic foraminifera is key to understanding benthic ecosystems and relevant biogeochemical cycles, especially in hypoxic environments.
33128276	2	14	theme	foraminifera	264:275	arg1	biology					245:251	The biology	241:251	The biology of benthic foraminifera	241:275	The biology of benthic foraminifera is key to understanding benthic ecosystems and relevant biogeochemical cycles, especially in hypoxic environments.
33128276	1	15	theme	broad	156:160	arg1	range					162:166	a broad range	154:166	a broad range of marine environments	154:189	Benthic foraminifera, members of Rhizaria, inhabit a broad range of marine environments and are particularly common in hypoxic sediments.
33128276	5	16	theme	bathyal	804:810	arg1	sediments					812:820	bathyal sediments	804:820	bathyal sediments of Sagami Bay, Japan	804:841	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	6	17	theme	electron-dense	1073:1086	arg1	structures					1088:1097	abundant electron-dense structures	1064:1097	abundant electron-dense structures dividing the cytoplasm	1064:1120	Observations by TEM revealed the presence of abundant electron-dense structures dividing the cytoplasm.
33128276	2	18	theme	benthic	256:262	arg1	foraminifera					264:275	benthic foraminifera	256:275	benthic foraminifera	256:275	The biology of benthic foraminifera is key to understanding benthic ecosystems and relevant biogeochemical cycles, especially in hypoxic environments.
33128276	3	19	theme	deep-sea	457:464	arg1	sediments					466:474	hypoxic deep-sea sediments	449:474	hypoxic deep-sea sediments	449:474	Chilostomella is a foraminiferal genus commonly found in hypoxic deep-sea sediments and has poorly understood ecological characteristics.
33128276	0	20	theme	Chitinous	9:17	arg1	Structures					19:28	Abundant Chitinous Structures	0:28	Abundant Chitinous Structures in Chilostomella (Foraminifera, Rhizaria)	0:70	Abundant Chitinous Structures in Chilostomella (Foraminifera, Rhizaria) and Their Potential Functions.
33128276	5	21	theme	ultra-thin	998:1007	arg1	sections					1009:1016	ultra-thin sections	998:1016	ultra-thin sections	998:1016	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	7	22	theme	histochemical	1132:1144	arg1	staining					1146:1153	histochemical staining	1132:1153	histochemical staining	1132:1153	Based on histochemical staining, these structures are shown to be composed of chitin.
33128276	0	23	theme	Abundant	0:7	arg1	Structures					19:28	Abundant Chitinous Structures	0:28	Abundant Chitinous Structures in Chilostomella (Foraminifera, Rhizaria)	0:70	Abundant Chitinous Structures in Chilostomella (Foraminifera, Rhizaria) and Their Potential Functions.
33128276	4	24	theme	lipids	585:590	arg1	compositions					563:574	the carbon isotopic compositions	543:574	the carbon isotopic compositions of their lipids	543:590	For example, the carbon isotopic compositions of their lipids are substantially different from other co-occurring genera, probably reflecting unique features of its metabolism.
33128276	4	24	theme	lipids	585:590	arg1	different					610:618	different	610:618	different	610:618	For example, the carbon isotopic compositions of their lipids are substantially different from other co-occurring genera, probably reflecting unique features of its metabolism.
33128276	2	25	theme	benthic	301:307	arg1	ecosystems					309:318	benthic ecosystems	301:318	benthic ecosystems	301:318	The biology of benthic foraminifera is key to understanding benthic ecosystems and relevant biogeochemical cycles, especially in hypoxic environments.
33128276	10	26	from	partition	1473:1481	arg1	chamber					1502:1508	a chamber	1500:1508	a chamber to increase the surface/volume ratio and/or act as a reactive site for some metabolic functions	1500:1604	These chitinous, plate-like structures may function to partition the cytoplasm in a chamber to increase the surface/volume ratio and/or act as a reactive site for some metabolic functions.
33128276	1	27	theme	marine	171:176	arg1	environments					178:189	marine environments	171:189	marine environments	171:189	Benthic foraminifera, members of Rhizaria, inhabit a broad range of marine environments and are particularly common in hypoxic sediments.
33128276	5	28	theme	semi-thin	860:868	arg1	sections					870:877	serial semi-thin sections	853:877	serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections	853:1016	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	5	29	theme	serial	853:858	arg1	sections					870:877	serial semi-thin sections	853:877	serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections	853:1016	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	3	30	located	found	440:444	arg2	genus					425:429	a foraminiferal genus	409:429	a foraminiferal genus commonly found in hypoxic deep-sea sediments	409:474	Chilostomella is a foraminiferal genus commonly found in hypoxic deep-sea sediments and has poorly understood ecological characteristics.
33128276	3	30	located	found	440:444	arg1	sediments					466:474	hypoxic deep-sea sediments	449:474	hypoxic deep-sea sediments	449:474	Chilostomella is a foraminiferal genus commonly found in hypoxic deep-sea sediments and has poorly understood ecological characteristics.
33128276	3	30	located	found	440:444	arg2	Chilostomella					392:404	Chilostomella	392:404	Chilostomella	392:404	Chilostomella is a foraminiferal genus commonly found in hypoxic deep-sea sediments and has poorly understood ecological characteristics.
33128276	1	31	theme	environments	178:189	arg1	range					162:166	a broad range	154:166	a broad range of marine environments	154:189	Benthic foraminifera, members of Rhizaria, inhabit a broad range of marine environments and are particularly common in hypoxic sediments.
33128276	5	32	theme	sections	1009:1016	arg1	observations					982:993	TEM observations	978:993	TEM observations of ultra-thin sections	978:1016	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	5	33	theme	ultrastructural	749:763	arg1	features					765:772	the cytoplasmic and ultrastructural features	729:772	the cytoplasmic and ultrastructural features	729:772	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	1	34	theme	Benthic	103:109	arg1	members					125:131	members	125:131	members of Rhizaria	125:143	Benthic foraminifera, members of Rhizaria, inhabit a broad range of marine environments and are particularly common in hypoxic sediments.
33128276	1	34	theme	Benthic	103:109	arg1	foraminifera					111:122	Benthic foraminifera	103:122	Benthic foraminifera	103:122	Benthic foraminifera, members of Rhizaria, inhabit a broad range of marine environments and are particularly common in hypoxic sediments.
33128276	5	35	theme	three-dimensional	930:946	arg1	reconstruction					948:961	a three-dimensional reconstruction	928:961	a three-dimensional reconstruction	928:961	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	1	36	theme	Rhizaria	136:143	arg1	members					125:131	members	125:131	members of Rhizaria	125:143	Benthic foraminifera, members of Rhizaria, inhabit a broad range of marine environments and are particularly common in hypoxic sediments.
33128276	1	36	theme	Rhizaria	136:143	arg1	foraminifera					111:122	Benthic foraminifera	103:122	Benthic foraminifera	103:122	Benthic foraminifera, members of Rhizaria, inhabit a broad range of marine environments and are particularly common in hypoxic sediments.
33128276	5	37	theme	TEM	978:980	arg1	observations					982:993	TEM observations	978:993	TEM observations of ultra-thin sections	978:1016	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	10	38	theme	reactive	1563:1570	arg1	site					1572:1575	a reactive site	1561:1575	a reactive site for some metabolic functions	1561:1604	These chitinous, plate-like structures may function to partition the cytoplasm in a chamber to increase the surface/volume ratio and/or act as a reactive site for some metabolic functions.
33128276	3	39	theme	hypoxic	449:455	arg1	sediments					466:474	hypoxic deep-sea sediments	449:474	hypoxic deep-sea sediments	449:474	Chilostomella is a foraminiferal genus commonly found in hypoxic deep-sea sediments and has poorly understood ecological characteristics.
33128276	4	40	theme	isotopic	554:561	arg1	compositions					563:574	the carbon isotopic compositions	543:574	the carbon isotopic compositions of their lipids	543:590	For example, the carbon isotopic compositions of their lipids are substantially different from other co-occurring genera, probably reflecting unique features of its metabolism.
33128276	4	40	theme	isotopic	554:561	arg1	different					610:618	different	610:618	different	610:618	For example, the carbon isotopic compositions of their lipids are substantially different from other co-occurring genera, probably reflecting unique features of its metabolism.
33128276	5	41	theme	Japan	837:841	arg1	sediments					812:820	bathyal sediments	804:820	bathyal sediments of Sagami Bay, Japan	804:841	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	0	42	dep	Foraminifera	48:59	arg1	Rhizaria					62:69	Rhizaria	62:69	Rhizaria	62:69	Abundant Chitinous Structures in Chilostomella (Foraminifera, Rhizaria) and Their Potential Functions.
33128276	10	43	theme	chitinous	1424:1432	arg1	structures					1446:1455	These chitinous, plate-like structures	1418:1455	structures	1446:1455	These chitinous, plate-like structures may function to partition the cytoplasm in a chamber to increase the surface/volume ratio and/or act as a reactive site for some metabolic functions.
33128276	5	44	theme	optical	897:903	arg1	microscope					905:914	an optical microscope	894:914	an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections	894:1016	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	4	45	theme	carbon	547:552	arg1	compositions					563:574	the carbon isotopic compositions	543:574	the carbon isotopic compositions of their lipids	543:590	For example, the carbon isotopic compositions of their lipids are substantially different from other co-occurring genera, probably reflecting unique features of its metabolism.
33128276	4	45	theme	carbon	547:552	arg1	different					610:618	different	610:618	different	610:618	For example, the carbon isotopic compositions of their lipids are substantially different from other co-occurring genera, probably reflecting unique features of its metabolism.
33128276	3	46	contain	has	480:482	arg1	Chilostomella					392:404	Chilostomella	392:404	Chilostomella	392:404	Chilostomella is a foraminiferal genus commonly found in hypoxic deep-sea sediments and has poorly understood ecological characteristics.
33128276	3	46	contain	has	480:482	arg1	genus					425:429	a foraminiferal genus	409:429	a foraminiferal genus commonly found in hypoxic deep-sea sediments	409:474	Chilostomella is a foraminiferal genus commonly found in hypoxic deep-sea sediments and has poorly understood ecological characteristics.
33128276	3	46	contain	has	480:482	arg2	characteristics					513:527	poorly understood ecological characteristics	484:527	poorly understood ecological characteristics	484:527	Chilostomella is a foraminiferal genus commonly found in hypoxic deep-sea sediments and has poorly understood ecological characteristics.
33128276	2	47	from	environments	378:389	arg1	key					280:282	key	280:282	key	280:282	The biology of benthic foraminifera is key to understanding benthic ecosystems and relevant biogeochemical cycles, especially in hypoxic environments.
33128276	2	47	from	environments	378:389	arg1	biology					245:251	The biology	241:251	The biology of benthic foraminifera	241:275	The biology of benthic foraminifera is key to understanding benthic ecosystems and relevant biogeochemical cycles, especially in hypoxic environments.
33128276	3	48	theme	foraminiferal	411:423	arg1	Chilostomella					392:404	Chilostomella	392:404	Chilostomella	392:404	Chilostomella is a foraminiferal genus commonly found in hypoxic deep-sea sediments and has poorly understood ecological characteristics.
33128276	3	48	theme	foraminiferal	411:423	arg1	genus					425:429	a foraminiferal genus	409:429	a foraminiferal genus commonly found in hypoxic deep-sea sediments	409:474	Chilostomella is a foraminiferal genus commonly found in hypoxic deep-sea sediments and has poorly understood ecological characteristics.
33128276	1	49	from	sediments	230:238	arg1	common					212:217	common	212:217	common	212:217	Benthic foraminifera, members of Rhizaria, inhabit a broad range of marine environments and are particularly common in hypoxic sediments.
33128276	2	50	theme	biogeochemical	333:346	arg1	cycles					348:353	relevant biogeochemical cycles	324:353	relevant biogeochemical cycles	324:353	The biology of benthic foraminifera is key to understanding benthic ecosystems and relevant biogeochemical cycles, especially in hypoxic environments.
33128276	9	51	theme	plate-like	1308:1317	arg1	morphology					1319:1328	a plate-like morphology	1306:1328	a plate-like morphology	1306:1328	These exhibited a plate-like morphology in the final chambers but became rolled up in earlier chambers (toward the proloculus).
33128276	1	52	from	common	212:217	arg1	sediments					230:238	hypoxic sediments	222:238	hypoxic sediments	222:238	Benthic foraminifera, members of Rhizaria, inhabit a broad range of marine environments and are particularly common in hypoxic sediments.
33128276	2	53	theme	relevant	324:331	arg1	cycles					348:353	relevant biogeochemical cycles	324:353	relevant biogeochemical cycles	324:353	The biology of benthic foraminifera is key to understanding benthic ecosystems and relevant biogeochemical cycles, especially in hypoxic environments.
33128276	5	54	theme	cytoplasmic	733:743	arg1	features					765:772	the cytoplasmic and ultrastructural features	729:772	the cytoplasmic and ultrastructural features	729:772	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
33128276	0	55	from	Functions	92:100	arg1	Foraminifera					48:59	Foraminifera	48:59	Foraminifera	48:59	Abundant Chitinous Structures in Chilostomella (Foraminifera, Rhizaria) and Their Potential Functions.
33128276	0	55	from	Functions	92:100	arg1	Chilostomella					33:45	Chilostomella	33:45	Chilostomella	33:45	Abundant Chitinous Structures in Chilostomella (Foraminifera, Rhizaria) and Their Potential Functions.
33128276	8	56	theme	final	1268:1272	arg1	chambers					1280:1287	the final seven chambers	1264:1287	the final seven chambers	1264:1287	Our 3D reconstruction revealed chitinous structures in the final seven chambers.
33128276	3	57	theme	ecological	502:511	arg1	characteristics					513:527	poorly understood ecological characteristics	484:527	poorly understood ecological characteristics	484:527	Chilostomella is a foraminiferal genus commonly found in hypoxic deep-sea sediments and has poorly understood ecological characteristics.
33128276	2	58	from	key	280:282	arg1	environments					378:389	hypoxic environments	370:389	hypoxic environments	370:389	The biology of benthic foraminifera is key to understanding benthic ecosystems and relevant biogeochemical cycles, especially in hypoxic environments.
33128276	3	59	theme	understood	491:500	arg1	characteristics					513:527	poorly understood ecological characteristics	484:527	poorly understood ecological characteristics	484:527	Chilostomella is a foraminiferal genus commonly found in hypoxic deep-sea sediments and has poorly understood ecological characteristics.
33128276	8	60	theme	3D	1213:1214	arg1	reconstruction					1216:1229	Our 3D reconstruction	1209:1229	Our 3D reconstruction	1209:1229	Our 3D reconstruction revealed chitinous structures in the final seven chambers.
33128276	10	61	theme	metabolic	1586:1594	arg1	functions					1596:1604	some metabolic functions	1581:1604	some metabolic functions	1581:1604	These chitinous, plate-like structures may function to partition the cytoplasm in a chamber to increase the surface/volume ratio and/or act as a reactive site for some metabolic functions.
33128276	2	62	theme	hypoxic	370:376	arg1	environments					378:389	hypoxic environments	370:389	hypoxic environments	370:389	The biology of benthic foraminifera is key to understanding benthic ecosystems and relevant biogeochemical cycles, especially in hypoxic environments.
33128276	4	63	theme	metabolism	695:704	arg1	features					679:686	unique features	672:686	unique features of its metabolism	672:704	For example, the carbon isotopic compositions of their lipids are substantially different from other co-occurring genera, probably reflecting unique features of its metabolism.
33128276	1	64	theme	hypoxic	222:228	arg1	sediments					230:238	hypoxic sediments	222:238	hypoxic sediments	222:238	Benthic foraminifera, members of Rhizaria, inhabit a broad range of marine environments and are particularly common in hypoxic sediments.
33128276	6	65	theme	structures	1088:1097	arg1	presence					1052:1059	the presence	1048:1059	the presence of abundant electron-dense structures dividing the cytoplasm	1048:1120	Observations by TEM revealed the presence of abundant electron-dense structures dividing the cytoplasm.
33128276	10	66	theme	plate-like	1435:1444	arg1	structures					1446:1455	These chitinous, plate-like structures	1418:1455	structures	1446:1455	These chitinous, plate-like structures may function to partition the cytoplasm in a chamber to increase the surface/volume ratio and/or act as a reactive site for some metabolic functions.
33128276	5	67	theme	ovoidea	791:797	arg1	features					765:772	the cytoplasmic and ultrastructural features	729:772	the cytoplasmic and ultrastructural features	729:772	Here, we investigated the cytoplasmic and ultrastructural features of Chilostomella ovoidea from bathyal sediments of Sagami Bay, Japan, based on serial semi-thin sections examined using an optical microscope followed by a three-dimensional reconstruction, combined with TEM observations of ultra-thin sections.
34915376	0	0	theme	packaging	94:102	arg1	films					104:108	phenolic acid-based active and hydrophobic packaging films	51:108	phenolic acid-based active and hydrophobic packaging films	51:108	Characterization of novel cellulose nanofibril and phenolic acid-based active and hydrophobic packaging films.
34915376	4	1	theme	different	527:535	arg1	mechanisms					546:555	two different reaction mechanisms	523:555	two different reaction mechanisms	523:555	In this study, CNF films were esterified to vanillic and syringic acid through two different reaction mechanisms.
34915376	5	2	theme	antioxidant	693:703	arg1	properties					705:714	antioxidant properties	693:714	antioxidant properties	693:714	The films were investigated for evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties.
34915376	6	3	with	esterification	739:752	arg1	acids					781:785	vanillic and syringic acids	759:785	vanillic and syringic acids	759:785	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	1	4	theme	biodegradable	151:163	arg1	nanofibril					121:130	Cellulose nanofibril	111:130	Cellulose nanofibril (CNF)	111:136	Cellulose nanofibril (CNF) is a natural biodegradable biopolymer with excellent mechanical and barrier properties.
34915376	1	4	theme	biodegradable	151:163	arg1	biopolymer					165:174	a natural biodegradable biopolymer	141:174	a natural biodegradable biopolymer with excellent mechanical and barrier properties	141:223	Cellulose nanofibril (CNF) is a natural biodegradable biopolymer with excellent mechanical and barrier properties.
34915376	0	5	theme	hydrophobic	82:92	arg1	films					104:108	phenolic acid-based active and hydrophobic packaging films	51:108	phenolic acid-based active and hydrophobic packaging films	51:108	Characterization of novel cellulose nanofibril and phenolic acid-based active and hydrophobic packaging films.
34915376	1	6	with	biopolymer	165:174	arg1	mechanical					191:200	mechanical	191:200	mechanical	191:200	Cellulose nanofibril (CNF) is a natural biodegradable biopolymer with excellent mechanical and barrier properties.
34915376	1	6	with	biopolymer	165:174	arg1	properties					214:223	excellent mechanical and barrier properties	181:223	properties	214:223	Cellulose nanofibril (CNF) is a natural biodegradable biopolymer with excellent mechanical and barrier properties.
34915376	5	7	theme	properties	643:652	arg1	evidence					590:597	evidence	590:597	evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties	590:714	The films were investigated for evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties.
34915376	3	8	theme	active	389:394	arg1	properties					432:441	antioxidant properties	420:441	antioxidant properties	420:441	Attachment of phenolic acids can improve its hydrophobicity and provide additional active functionalities such as antioxidant properties.
34915376	3	8	theme	active	389:394	arg1	functionalities					396:410	additional active functionalities	378:410	additional active functionalities such as antioxidant properties	378:441	Attachment of phenolic acids can improve its hydrophobicity and provide additional active functionalities such as antioxidant properties.
34915376	6	9	theme	higher	852:857	arg1	activity					877:884	a significantly higher ABTS+· scavenging activity	836:884	a significantly higher ABTS+· scavenging activity (76 ± 18%)	836:895	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	6	9	theme	higher	852:857	arg1	%					894:894	76 ± 18%	887:894	76 ± 18%	887:894	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	7	10	theme	films	1036:1040	arg1	hydrophobicity					1014:1027	the hydrophobicity	1010:1027	the hydrophobicity of the films with a water contact angle of 94 ± 3°	1010:1078	Similarly, esterification of phenolic acids significantly improved the hydrophobicity of the films with a water contact angle of 94 ± 3° when compared to control CNF films (46 ± 5°).
34915376	0	11	theme	films	104:108	arg1	Characterization					0:15	Characterization	0:15	Characterization of novel cellulose nanofibril and phenolic acid-based active and hydrophobic packaging films.	0:109	Characterization of novel cellulose nanofibril and phenolic acid-based active and hydrophobic packaging films.
34915376	5	12	theme	crystallinity	655:667	arg1	evidence					590:597	evidence	590:597	evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties	590:714	The films were investigated for evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties.
34915376	4	13	theme	syringic	501:508	arg1	acid					510:513	vanillic and syringic acid	488:513	vanillic and syringic acid	488:513	In this study, CNF films were esterified to vanillic and syringic acid through two different reaction mechanisms.
34915376	5	14	theme	thermal	670:676	arg1	stability					678:686	thermal stability	670:686	thermal stability	670:686	The films were investigated for evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties.
34915376	6	15	theme	CNF	820:822	arg1	films					824:828	CNF films	820:828	CNF films	820:828	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	2	16	theme	properties	294:303	arg1	deterioration					273:285	moisture-induced deterioration	256:285	moisture-induced deterioration of its properties	256:303	However, it is susceptible to moisture-induced deterioration of its properties.
34915376	6	17	theme	syringic	772:779	arg1	acids					781:785	vanillic and syringic acids	759:785	vanillic and syringic acids	759:785	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	3	18	theme	additional	378:387	arg1	properties					432:441	antioxidant properties	420:441	antioxidant properties	420:441	Attachment of phenolic acids can improve its hydrophobicity and provide additional active functionalities such as antioxidant properties.
34915376	3	18	theme	additional	378:387	arg1	functionalities					396:410	additional active functionalities	378:410	additional active functionalities such as antioxidant properties	378:441	Attachment of phenolic acids can improve its hydrophobicity and provide additional active functionalities such as antioxidant properties.
34915376	5	19	theme	stability	678:686	arg1	evidence					590:597	evidence	590:597	evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties	590:714	The films were investigated for evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties.
34915376	6	20	theme	ABTS+·	859:864	arg1	activity					877:884	a significantly higher ABTS+· scavenging activity	836:884	a significantly higher ABTS+· scavenging activity (76 ± 18%)	836:895	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	6	20	theme	ABTS+·	859:864	arg1	%					894:894	76 ± 18%	887:894	76 ± 18%	887:894	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	3	21	theme	antioxidant	420:430	arg1	properties					432:441	antioxidant properties	420:441	antioxidant properties	420:441	Attachment of phenolic acids can improve its hydrophobicity and provide additional active functionalities such as antioxidant properties.
34915376	5	22	theme	hydrophobicity	616:629	arg1	evidence					590:597	evidence	590:597	evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties	590:714	The films were investigated for evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties.
34915376	6	23	theme	vanillic	759:766	arg1	acids					781:785	vanillic and syringic acids	759:785	vanillic and syringic acids	759:785	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	8	24	theme	Covalent	1126:1133	arg1	attachment					1135:1144	Covalent attachment	1126:1144	Covalent attachment of phenolic acids	1126:1162	Covalent attachment of phenolic acids can improve hydrophobicity while providing additional functionality to CNF important for food packaging applications.
34915376	5	25	theme	properties	705:714	arg1	evidence					590:597	evidence	590:597	evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties	590:714	The films were investigated for evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties.
34915376	0	26	theme	cellulose	26:34	arg1	nanofibril					36:45	novel cellulose nanofibril	20:45	novel cellulose nanofibril	20:45	Characterization of novel cellulose nanofibril and phenolic acid-based active and hydrophobic packaging films.
34915376	5	27	theme	mechanical	632:641	arg1	properties					643:652	mechanical properties	632:652	mechanical properties	632:652	The films were investigated for evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties.
34915376	1	28	theme	Cellulose	111:119	arg1	biopolymer					165:174	a natural biodegradable biopolymer	141:174	a natural biodegradable biopolymer with excellent mechanical and barrier properties	141:223	Cellulose nanofibril (CNF) is a natural biodegradable biopolymer with excellent mechanical and barrier properties.
34915376	1	28	theme	Cellulose	111:119	arg1	CNF					133:135	CNF	133:135	CNF	133:135	Cellulose nanofibril (CNF) is a natural biodegradable biopolymer with excellent mechanical and barrier properties.
34915376	1	28	theme	Cellulose	111:119	arg1	nanofibril					121:130	Cellulose nanofibril	111:130	Cellulose nanofibril (CNF)	111:136	Cellulose nanofibril (CNF) is a natural biodegradable biopolymer with excellent mechanical and barrier properties.
34915376	1	29	theme	barrier	206:212	arg1	properties					214:223	excellent mechanical and barrier properties	181:223	properties	214:223	Cellulose nanofibril (CNF) is a natural biodegradable biopolymer with excellent mechanical and barrier properties.
34915376	0	30	theme	novel	20:24	arg1	nanofibril					36:45	novel cellulose nanofibril	20:45	novel cellulose nanofibril	20:45	Characterization of novel cellulose nanofibril and phenolic acid-based active and hydrophobic packaging films.
34915376	7	31	theme	control	1097:1103	arg1	46 ± 5°					1116:1122	46 ± 5°	1116:1122	46 ± 5°	1116:1122	Similarly, esterification of phenolic acids significantly improved the hydrophobicity of the films with a water contact angle of 94 ± 3° when compared to control CNF films (46 ± 5°).
34915376	7	31	theme	control	1097:1103	arg1	films					1109:1113	control CNF films	1097:1113	control CNF films (46 ± 5°)	1097:1123	Similarly, esterification of phenolic acids significantly improved the hydrophobicity of the films with a water contact angle of 94 ± 3° when compared to control CNF films (46 ± 5°).
34915376	6	32	theme	CNF	922:924	arg1	%					939:939	30 ± 6%	933:939	30 ± 6%	933:939	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	6	32	theme	CNF	922:924	arg1	films					926:930	control CNF films	914:930	control CNF films (30 ± 6%)	914:940	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	0	33	theme	nanofibril	36:45	arg1	Characterization					0:15	Characterization	0:15	Characterization of novel cellulose nanofibril and phenolic acid-based active and hydrophobic packaging films.	0:109	Characterization of novel cellulose nanofibril and phenolic acid-based active and hydrophobic packaging films.
34915376	7	34	theme	CNF	1105:1107	arg1	46 ± 5°					1116:1122	46 ± 5°	1116:1122	46 ± 5°	1116:1122	Similarly, esterification of phenolic acids significantly improved the hydrophobicity of the films with a water contact angle of 94 ± 3° when compared to control CNF films (46 ± 5°).
34915376	7	34	theme	CNF	1105:1107	arg1	films					1109:1113	control CNF films	1097:1113	control CNF films (46 ± 5°)	1097:1123	Similarly, esterification of phenolic acids significantly improved the hydrophobicity of the films with a water contact angle of 94 ± 3° when compared to control CNF films (46 ± 5°).
34915376	6	35	theme	control	914:920	arg1	%					939:939	30 ± 6%	933:939	30 ± 6%	933:939	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	6	35	theme	control	914:920	arg1	films					926:930	control CNF films	914:930	control CNF films (30 ± 6%)	914:940	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	8	36	theme	food	1253:1256	arg1	applications					1268:1279	food packaging applications	1253:1279	food packaging applications	1253:1279	Covalent attachment of phenolic acids can improve hydrophobicity while providing additional functionality to CNF important for food packaging applications.
34915376	8	37	theme	important	1239:1247	arg1	CNF					1235:1237	CNF	1235:1237	CNF important for food packaging applications	1235:1279	Covalent attachment of phenolic acids can improve hydrophobicity while providing additional functionality to CNF important for food packaging applications.
34915376	0	38	theme	acid-based	60:69	arg1	films					104:108	phenolic acid-based active and hydrophobic packaging films	51:108	phenolic acid-based active and hydrophobic packaging films	51:108	Characterization of novel cellulose nanofibril and phenolic acid-based active and hydrophobic packaging films.
34915376	8	39	theme	additional	1207:1216	arg1	functionality					1218:1230	additional functionality	1207:1230	additional functionality	1207:1230	Covalent attachment of phenolic acids can improve hydrophobicity while providing additional functionality to CNF important for food packaging applications.
34915376	3	40	theme	acids	329:333	arg1	Attachment					306:315	Attachment	306:315	Attachment of phenolic acids	306:333	Attachment of phenolic acids can improve its hydrophobicity and provide additional active functionalities such as antioxidant properties.
34915376	4	41	theme	vanillic	488:495	arg1	acid					510:513	vanillic and syringic acid	488:513	vanillic and syringic acid	488:513	In this study, CNF films were esterified to vanillic and syringic acid through two different reaction mechanisms.
34915376	8	42	theme	acids	1158:1162	arg1	attachment					1135:1144	Covalent attachment	1126:1144	Covalent attachment of phenolic acids	1126:1162	Covalent attachment of phenolic acids can improve hydrophobicity while providing additional functionality to CNF important for food packaging applications.
34915376	0	43	theme	phenolic	51:58	arg1	films					104:108	phenolic acid-based active and hydrophobic packaging films	51:108	phenolic acid-based active and hydrophobic packaging films	51:108	Characterization of novel cellulose nanofibril and phenolic acid-based active and hydrophobic packaging films.
34915376	7	44	with	hydrophobicity	1014:1027	arg1	angle					1063:1067	a water contact angle	1047:1067	a water contact angle of 94 ± 3°	1047:1078	Similarly, esterification of phenolic acids significantly improved the hydrophobicity of the films with a water contact angle of 94 ± 3° when compared to control CNF films (46 ± 5°).
34915376	4	45	theme	CNF	459:461	arg1	films					463:467	CNF films	459:467	CNF films	459:467	In this study, CNF films were esterified to vanillic and syringic acid through two different reaction mechanisms.
34915376	7	46	theme	water	1049:1053	arg1	angle					1063:1067	a water contact angle	1047:1067	a water contact angle of 94 ± 3°	1047:1078	Similarly, esterification of phenolic acids significantly improved the hydrophobicity of the films with a water contact angle of 94 ± 3° when compared to control CNF films (46 ± 5°).
34915376	7	47	theme	phenolic	972:979	arg1	acids					981:985	phenolic acids	972:985	phenolic acids	972:985	Similarly, esterification of phenolic acids significantly improved the hydrophobicity of the films with a water contact angle of 94 ± 3° when compared to control CNF films (46 ± 5°).
34915376	7	48	theme	94 ± 3°	1072:1078	arg1	angle					1063:1067	a water contact angle	1047:1067	a water contact angle of 94 ± 3°	1047:1078	Similarly, esterification of phenolic acids significantly improved the hydrophobicity of the films with a water contact angle of 94 ± 3° when compared to control CNF films (46 ± 5°).
34915376	7	49	theme	acids	981:985	arg1	esterification					954:967	esterification	954:967	esterification of phenolic acids	954:985	Similarly, esterification of phenolic acids significantly improved the hydrophobicity of the films with a water contact angle of 94 ± 3° when compared to control CNF films (46 ± 5°).
34915376	5	50	theme	modification	602:613	arg1	evidence					590:597	evidence	590:597	evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties	590:714	The films were investigated for evidence of modification, hydrophobicity, mechanical properties, crystallinity, thermal stability, and antioxidant properties.
34915376	3	51	theme	phenolic	320:327	arg1	acids					329:333	phenolic acids	320:333	phenolic acids	320:333	Attachment of phenolic acids can improve its hydrophobicity and provide additional active functionalities such as antioxidant properties.
34915376	6	52	theme	scavenging	866:875	arg1	activity					877:884	a significantly higher ABTS+· scavenging activity	836:884	a significantly higher ABTS+· scavenging activity (76 ± 18%)	836:895	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	6	52	theme	scavenging	866:875	arg1	%					894:894	76 ± 18%	887:894	76 ± 18%	887:894	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	8	53	theme	packaging	1258:1266	arg1	applications					1268:1279	food packaging applications	1253:1279	food packaging applications	1253:1279	Covalent attachment of phenolic acids can improve hydrophobicity while providing additional functionality to CNF important for food packaging applications.
34915376	7	54	theme	contact	1055:1061	arg1	angle					1063:1067	a water contact angle	1047:1067	a water contact angle of 94 ± 3°	1047:1078	Similarly, esterification of phenolic acids significantly improved the hydrophobicity of the films with a water contact angle of 94 ± 3° when compared to control CNF films (46 ± 5°).
34915376	2	55	theme	moisture-induced	256:271	arg1	deterioration					273:285	moisture-induced deterioration	256:285	moisture-induced deterioration of its properties	256:303	However, it is susceptible to moisture-induced deterioration of its properties.
34915376	0	56	theme	active	71:76	arg1	films					104:108	phenolic acid-based active and hydrophobic packaging films	51:108	phenolic acid-based active and hydrophobic packaging films	51:108	Characterization of novel cellulose nanofibril and phenolic acid-based active and hydrophobic packaging films.
34915376	4	57	theme	reaction	537:544	arg1	mechanisms					546:555	two different reaction mechanisms	523:555	two different reaction mechanisms	523:555	In this study, CNF films were esterified to vanillic and syringic acid through two different reaction mechanisms.
34915376	6	58	theme	antioxidant	796:806	arg1	activity					808:815	antioxidant activity	796:815	antioxidant activity to CNF films	796:828	Results indicate that esterification with vanillic and syringic acids imparted antioxidant activity to CNF films, with a significantly higher ABTS+· scavenging activity (76 ± 18%) when compared to control CNF films (30 ± 6%).
34915376	1	59	theme	natural	143:149	arg1	nanofibril					121:130	Cellulose nanofibril	111:130	Cellulose nanofibril (CNF)	111:136	Cellulose nanofibril (CNF) is a natural biodegradable biopolymer with excellent mechanical and barrier properties.
34915376	1	59	theme	natural	143:149	arg1	biopolymer					165:174	a natural biodegradable biopolymer	141:174	a natural biodegradable biopolymer with excellent mechanical and barrier properties	141:223	Cellulose nanofibril (CNF) is a natural biodegradable biopolymer with excellent mechanical and barrier properties.
34915376	8	60	theme	phenolic	1149:1156	arg1	acids					1158:1162	phenolic acids	1149:1162	phenolic acids	1149:1162	Covalent attachment of phenolic acids can improve hydrophobicity while providing additional functionality to CNF important for food packaging applications.
32458678	5	0	theme	BC-PDES	861:867	arg1	composites					869:878	BC-PDES composites	861:878	BC-PDES composites	861:878	Furthermore, compared to deliquescent PDESs, BC-PDES composites showed obvious mechanical stability, which maintain good mechanical properties even when exposed to high humidity for 120 days.
32458678	4	1	theme	8	761:761	arg1	×					763:763	×	763:763	×	763:763	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	2	2	theme	conductors	378:387	arg1	use					365:367	the long-term use	351:367	the long-term use of ionic conductors	351:387	The sensitivity toward humidity inevitably leads to dehydration or deliquescence issues, which will limit the long-term use of ionic conductors.
32458678	8	3	used	used	1346:1349	arg2	conductors					1328:1337	the BC-PDES ionic conductors	1310:1337	the BC-PDES ionic conductors	1310:1337	Moreover, the BC-PDES ionic conductors can be used in flexible, patterned electroluminescent devices.
32458678	5	4	theme	good	932:935	arg1	properties					948:957	good mechanical properties	932:957	good mechanical properties	932:957	Furthermore, compared to deliquescent PDESs, BC-PDES composites showed obvious mechanical stability, which maintain good mechanical properties even when exposed to high humidity for 120 days.
32458678	4	5	theme	interfacial	632:642	arg1	interaction					644:654	strong interfacial interaction	625:654	strong interfacial interaction	625:654	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	7	6	theme	humans	1233:1238	arg1	activity					1221:1228	physical activity	1212:1228	physical activity of humans such as limb movements, throat vibrations, and handwriting	1212:1297	Thus, they can easily serve as supersensitive sensors to recognize physical activity of humans such as limb movements, throat vibrations, and handwriting.
32458678	7	7	theme	throat	1264:1269	arg1	vibrations					1271:1280	throat vibrations	1264:1280	throat vibrations	1264:1280	Thus, they can easily serve as supersensitive sensors to recognize physical activity of humans such as limb movements, throat vibrations, and handwriting.
32458678	5	8	theme	mechanical	937:946	arg1	properties					948:957	good mechanical properties	932:957	good mechanical properties	932:957	Furthermore, compared to deliquescent PDESs, BC-PDES composites showed obvious mechanical stability, which maintain good mechanical properties even when exposed to high humidity for 120 days.
32458678	4	9	theme	Pa	769:770	arg1	properties					729:738	significantly enhanced mechanical properties	695:738	significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa)	695:813	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	9	theme	Pa	769:770	arg1	strength					749:756	tensile strength	741:756	tensile strength of 8 × 105 Pa	741:770	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	9	theme	Pa	769:770	arg1	strength					788:795	compressive strength	776:795	compressive strength of 6.68 × 106 Pa	776:812	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	7	10	theme	physical	1212:1219	arg1	activity					1221:1228	physical activity	1212:1228	physical activity of humans such as limb movements, throat vibrations, and handwriting	1212:1297	Thus, they can easily serve as supersensitive sensors to recognize physical activity of humans such as limb movements, throat vibrations, and handwriting.
32458678	2	11	theme	ionic	372:376	arg1	conductors					378:387	ionic conductors	372:387	ionic conductors	372:387	The sensitivity toward humidity inevitably leads to dehydration or deliquescence issues, which will limit the long-term use of ionic conductors.
32458678	4	12	theme	ionic	674:678	arg1	conductor					680:688	the BC-PDES ionic conductor	662:688	the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa)	662:813	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	1	13	theme	Ionic	89:93	arg1	conductors					95:104	Ionic conductors	89:104	Ionic conductors	89:104	Ionic conductors are normally prepared from water-based materials in the solid form and feature a combination of intrinsic transparency and stretchability.
32458678	4	14	theme	mechanical	718:727	arg1	properties					729:738	significantly enhanced mechanical properties	695:738	significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa)	695:813	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	14	theme	mechanical	718:727	arg1	strength					749:756	tensile strength	741:756	tensile strength of 8 × 105 Pa	741:770	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	14	theme	mechanical	718:727	arg1	strength					788:795	compressive strength	776:795	compressive strength of 6.68 × 106 Pa	776:812	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	15	theme	strong	625:630	arg1	interaction					644:654	strong interfacial interaction	625:654	strong interfacial interaction	625:654	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	3	16	theme	natural	429:435	arg1	BC					458:459	BC	458:459	BC	458:459	Here, a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs) is developed for addressing the abovementioned drawbacks.
32458678	3	16	theme	natural	429:435	arg1	cellulose					447:455	natural bacterial cellulose	429:455	natural bacterial cellulose (BC)	429:460	Here, a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs) is developed for addressing the abovementioned drawbacks.
32458678	3	17	theme	abovementioned	543:556	arg1	drawbacks					558:566	the abovementioned drawbacks	539:566	the abovementioned drawbacks	539:566	Here, a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs) is developed for addressing the abovementioned drawbacks.
32458678	4	18	theme	enhanced	709:716	arg1	properties					729:738	significantly enhanced mechanical properties	695:738	significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa)	695:813	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	18	theme	enhanced	709:716	arg1	strength					749:756	tensile strength	741:756	tensile strength of 8 × 105 Pa	741:770	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	18	theme	enhanced	709:716	arg1	strength					788:795	compressive strength	776:795	compressive strength of 6.68 × 106 Pa	776:812	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	3	19	theme	ionic	404:408	arg1	conductor					410:418	a novel ionic conductor	396:418	a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs)	396:509	Here, a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs) is developed for addressing the abovementioned drawbacks.
32458678	9	20	theme	other	1582:1586	arg1	products					1588:1595	other products	1582:1595	other products	1582:1595	This work provides an efficient strategy for making cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products.
32458678	5	21	theme	high	980:983	arg1	humidity					985:992	high humidity	980:992	high humidity	980:992	Furthermore, compared to deliquescent PDESs, BC-PDES composites showed obvious mechanical stability, which maintain good mechanical properties even when exposed to high humidity for 120 days.
32458678	9	22	theme	functional	1486:1495	arg1	conductors					1503:1512	cellulose-based sustainable and functional ionic conductors	1454:1512	cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products	1454:1595	This work provides an efficient strategy for making cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products.
32458678	0	23	theme	Cellulose	0:8	arg1	Conductors					37:46	Cellulose Nanofiber-Reinforced Ionic Conductors	0:46	Cellulose Nanofiber-Reinforced Ionic Conductors for Multifunctional Sensors and Devices.	0:87	Cellulose Nanofiber-Reinforced Ionic Conductors for Multifunctional Sensors and Devices.
32458678	4	24	theme	superstrong	573:583	arg1	network					613:619	The superstrong three-dimensional nanofiber network	569:619	The superstrong three-dimensional nanofiber network	569:619	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	5	25	theme	mechanical	895:904	arg1	stability					906:914	obvious mechanical stability	887:914	obvious mechanical stability	887:914	Furthermore, compared to deliquescent PDESs, BC-PDES composites showed obvious mechanical stability, which maintain good mechanical properties even when exposed to high humidity for 120 days.
32458678	4	26	theme	compressive	776:786	arg1	properties					729:738	significantly enhanced mechanical properties	695:738	significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa)	695:813	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	26	theme	compressive	776:786	arg1	strength					788:795	compressive strength	776:795	compressive strength of 6.68 × 106 Pa	776:812	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	1	27	theme	intrinsic	202:210	arg1	transparency					212:223	intrinsic transparency	202:223	intrinsic transparency	202:223	Ionic conductors are normally prepared from water-based materials in the solid form and feature a combination of intrinsic transparency and stretchability.
32458678	7	28	theme	supersensitive	1176:1189	arg1	sensors					1191:1197	supersensitive sensors	1176:1197	supersensitive sensors	1176:1197	Thus, they can easily serve as supersensitive sensors to recognize physical activity of humans such as limb movements, throat vibrations, and handwriting.
32458678	7	28	theme	supersensitive	1176:1189	arg1	they					1151:1154	they	1151:1154	they	1151:1154	Thus, they can easily serve as supersensitive sensors to recognize physical activity of humans such as limb movements, throat vibrations, and handwriting.
32458678	5	29	theme	deliquescent	841:852	arg1	PDESs					854:858	deliquescent PDESs	841:858	deliquescent PDESs	841:858	Furthermore, compared to deliquescent PDESs, BC-PDES composites showed obvious mechanical stability, which maintain good mechanical properties even when exposed to high humidity for 120 days.
32458678	8	30	theme	BC-PDES	1314:1320	arg1	conductors					1328:1337	the BC-PDES ionic conductors	1310:1337	the BC-PDES ionic conductors	1310:1337	Moreover, the BC-PDES ionic conductors can be used in flexible, patterned electroluminescent devices.
32458678	1	31	from	materials	145:153	arg1	form					168:171	the solid form	158:171	the solid form	158:171	Ionic conductors are normally prepared from water-based materials in the solid form and feature a combination of intrinsic transparency and stretchability.
32458678	9	32	theme	sustainable	1470:1480	arg1	conductors					1503:1512	cellulose-based sustainable and functional ionic conductors	1454:1512	cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products	1454:1595	This work provides an efficient strategy for making cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products.
32458678	3	33	theme	deep	480:483	arg1	PDESs					504:508	PDESs	504:508	PDESs	504:508	Here, a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs) is developed for addressing the abovementioned drawbacks.
32458678	3	33	theme	deep	480:483	arg1	solvents					494:501	polymerizable deep eutectic solvents	466:501	polymerizable deep eutectic solvents (PDESs)	466:509	Here, a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs) is developed for addressing the abovementioned drawbacks.
32458678	3	34	theme	novel	398:402	arg1	conductor					410:418	a novel ionic conductor	396:418	a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs)	396:509	Here, a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs) is developed for addressing the abovementioned drawbacks.
32458678	4	35	theme	nanofiber	603:611	arg1	network					613:619	The superstrong three-dimensional nanofiber network	569:619	The superstrong three-dimensional nanofiber network	569:619	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	2	36	theme	deliquescence	312:324	arg1	issues					326:331	deliquescence issues	312:331	deliquescence issues	312:331	The sensitivity toward humidity inevitably leads to dehydration or deliquescence issues, which will limit the long-term use of ionic conductors.
32458678	6	37	contain	possess	1045:1051	arg2	sensitivity					1062:1072	multiple sensitivity	1053:1072	multiple sensitivity to external stimulus	1053:1093	These materials were demonstrated to possess multiple sensitivity to external stimulus, such as strain, pressure, bend, and temperature.
32458678	6	37	contain	possess	1045:1051	arg1	materials					1014:1022	These materials	1008:1022	These materials	1008:1022	These materials were demonstrated to possess multiple sensitivity to external stimulus, such as strain, pressure, bend, and temperature.
32458678	9	38	theme	cellulose-based	1454:1468	arg1	conductors					1503:1512	cellulose-based sustainable and functional ionic conductors	1454:1512	cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products	1454:1595	This work provides an efficient strategy for making cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products.
32458678	3	39	theme	eutectic	485:492	arg1	PDESs					504:508	PDESs	504:508	PDESs	504:508	Here, a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs) is developed for addressing the abovementioned drawbacks.
32458678	3	39	theme	eutectic	485:492	arg1	solvents					494:501	polymerizable deep eutectic solvents	466:501	polymerizable deep eutectic solvents (PDESs)	466:509	Here, a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs) is developed for addressing the abovementioned drawbacks.
32458678	0	40	theme	Multifunctional	52:66	arg1	Sensors					68:74	Multifunctional Sensors	52:74	Multifunctional Sensors	52:74	Cellulose Nanofiber-Reinforced Ionic Conductors for Multifunctional Sensors and Devices.
32458678	4	41	theme	three-dimensional	585:601	arg1	network					613:619	The superstrong three-dimensional nanofiber network	569:619	The superstrong three-dimensional nanofiber network	569:619	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	8	42	dep	flexible	1354:1361	arg1	patterned					1364:1372	patterned	1364:1372	patterned	1364:1372	Moreover, the BC-PDES ionic conductors can be used in flexible, patterned electroluminescent devices.
32458678	9	43	theme	ionic	1497:1501	arg1	conductors					1503:1512	cellulose-based sustainable and functional ionic conductors	1454:1512	cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products	1454:1595	This work provides an efficient strategy for making cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products.
32458678	1	44	theme	stretchability	229:242	arg1	combination					187:197	a combination	185:197	a combination of intrinsic transparency and stretchability	185:242	Ionic conductors are normally prepared from water-based materials in the solid form and feature a combination of intrinsic transparency and stretchability.
32458678	3	45	theme	bacterial	437:445	arg1	BC					458:459	BC	458:459	BC	458:459	Here, a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs) is developed for addressing the abovementioned drawbacks.
32458678	3	45	theme	bacterial	437:445	arg1	cellulose					447:455	natural bacterial cellulose	429:455	natural bacterial cellulose (BC)	429:460	Here, a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs) is developed for addressing the abovementioned drawbacks.
32458678	9	46	theme	broad	1525:1529	arg1	application					1531:1541	broad application	1525:1541	broad application	1525:1541	This work provides an efficient strategy for making cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products.
32458678	3	47	theme	polymerizable	466:478	arg1	PDESs					504:508	PDESs	504:508	PDESs	504:508	Here, a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs) is developed for addressing the abovementioned drawbacks.
32458678	3	47	theme	polymerizable	466:478	arg1	solvents					494:501	polymerizable deep eutectic solvents	466:501	polymerizable deep eutectic solvents (PDESs)	466:509	Here, a novel ionic conductor based on natural bacterial cellulose (BC) and polymerizable deep eutectic solvents (PDESs) is developed for addressing the abovementioned drawbacks.
32458678	8	48	theme	flexible	1354:1361	arg1	devices					1393:1399	flexible, patterned electroluminescent devices	1354:1399	flexible, patterned electroluminescent devices	1354:1399	Moreover, the BC-PDES ionic conductors can be used in flexible, patterned electroluminescent devices.
32458678	8	49	theme	electroluminescent	1374:1391	arg1	devices					1393:1399	flexible, patterned electroluminescent devices	1354:1399	flexible, patterned electroluminescent devices	1354:1399	Moreover, the BC-PDES ionic conductors can be used in flexible, patterned electroluminescent devices.
32458678	1	50	theme	water-based	133:143	arg1	materials					145:153	water-based materials	133:153	water-based materials in the solid form	133:171	Ionic conductors are normally prepared from water-based materials in the solid form and feature a combination of intrinsic transparency and stretchability.
32458678	9	51	theme	flexible	1557:1564	arg1	electronics					1566:1576	artificial flexible electronics	1546:1576	artificial flexible electronics	1546:1576	This work provides an efficient strategy for making cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products.
32458678	9	52	contain	have	1520:1523	arg2	application					1531:1541	broad application	1525:1541	broad application	1525:1541	This work provides an efficient strategy for making cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products.
32458678	9	52	contain	have	1520:1523	arg1	conductors					1503:1512	cellulose-based sustainable and functional ionic conductors	1454:1512	cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products	1454:1595	This work provides an efficient strategy for making cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products.
32458678	4	53	theme	105	765:767	arg1	×					763:763	×	763:763	×	763:763	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	54	theme	tensile	741:747	arg1	properties					729:738	significantly enhanced mechanical properties	695:738	significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa)	695:813	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	54	theme	tensile	741:747	arg1	strength					749:756	tensile strength	741:756	tensile strength of 8 × 105 Pa	741:770	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	8	55	theme	ionic	1322:1326	arg1	conductors					1328:1337	the BC-PDES ionic conductors	1310:1337	the BC-PDES ionic conductors	1310:1337	Moreover, the BC-PDES ionic conductors can be used in flexible, patterned electroluminescent devices.
32458678	6	56	theme	external	1077:1084	arg1	stimulus					1086:1093	external stimulus	1077:1093	external stimulus	1077:1093	These materials were demonstrated to possess multiple sensitivity to external stimulus, such as strain, pressure, bend, and temperature.
32458678	4	57	theme	Pa	811:812	arg1	properties					729:738	significantly enhanced mechanical properties	695:738	significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa)	695:813	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	57	theme	Pa	811:812	arg1	strength					749:756	tensile strength	741:756	tensile strength of 8 × 105 Pa	741:770	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	57	theme	Pa	811:812	arg1	strength					788:795	compressive strength	776:795	compressive strength of 6.68 × 106 Pa	776:812	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	58	with	conductor	680:688	arg1	properties					729:738	significantly enhanced mechanical properties	695:738	significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa)	695:813	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	58	with	conductor	680:688	arg1	strength					749:756	tensile strength	741:756	tensile strength of 8 × 105 Pa	741:770	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	58	with	conductor	680:688	arg1	strength					788:795	compressive strength	776:795	compressive strength of 6.68 × 106 Pa	776:812	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	59	dep	properties	729:738	arg1	properties					729:738	significantly enhanced mechanical properties	695:738	significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa)	695:813	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	59	dep	properties	729:738	arg1	strength					749:756	tensile strength	741:756	tensile strength of 8 × 105 Pa	741:770	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	4	59	dep	properties	729:738	arg1	strength					788:795	compressive strength	776:795	compressive strength of 6.68 × 106 Pa	776:812	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	2	60	theme	long-term	355:363	arg1	use					365:367	the long-term use	351:367	the long-term use of ionic conductors	351:387	The sensitivity toward humidity inevitably leads to dehydration or deliquescence issues, which will limit the long-term use of ionic conductors.
32458678	9	61	theme	artificial	1546:1555	arg1	electronics					1566:1576	artificial flexible electronics	1546:1576	artificial flexible electronics	1546:1576	This work provides an efficient strategy for making cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products.
32458678	7	62	theme	limb	1248:1251	arg1	movements					1253:1261	limb movements	1248:1261	limb movements	1248:1261	Thus, they can easily serve as supersensitive sensors to recognize physical activity of humans such as limb movements, throat vibrations, and handwriting.
32458678	5	63	theme	obvious	887:893	arg1	stability					906:914	obvious mechanical stability	887:914	obvious mechanical stability	887:914	Furthermore, compared to deliquescent PDESs, BC-PDES composites showed obvious mechanical stability, which maintain good mechanical properties even when exposed to high humidity for 120 days.
32458678	1	64	theme	transparency	212:223	arg1	combination					187:197	a combination	185:197	a combination of intrinsic transparency and stretchability	185:242	Ionic conductors are normally prepared from water-based materials in the solid form and feature a combination of intrinsic transparency and stretchability.
32458678	1	65	theme	solid	162:166	arg1	form					168:171	the solid form	158:171	the solid form	158:171	Ionic conductors are normally prepared from water-based materials in the solid form and feature a combination of intrinsic transparency and stretchability.
32458678	4	66	theme	BC-PDES	666:672	arg1	conductor					680:688	the BC-PDES ionic conductor	662:688	the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa)	662:813	The superstrong three-dimensional nanofiber network and strong interfacial interaction endow the BC-PDES ionic conductor with significantly enhanced mechanical properties (tensile strength of 8 × 105 Pa and compressive strength of 6.68 × 106 Pa).
32458678	0	67	theme	Ionic	31:35	arg1	Conductors					37:46	Cellulose Nanofiber-Reinforced Ionic Conductors	0:46	Cellulose Nanofiber-Reinforced Ionic Conductors for Multifunctional Sensors and Devices.	0:87	Cellulose Nanofiber-Reinforced Ionic Conductors for Multifunctional Sensors and Devices.
32458678	0	68	theme	Nanofiber-Reinforced	10:29	arg1	Conductors					37:46	Cellulose Nanofiber-Reinforced Ionic Conductors	0:46	Cellulose Nanofiber-Reinforced Ionic Conductors for Multifunctional Sensors and Devices.	0:87	Cellulose Nanofiber-Reinforced Ionic Conductors for Multifunctional Sensors and Devices.
32458678	9	69	theme	efficient	1424:1432	arg1	strategy					1434:1441	an efficient strategy	1421:1441	an efficient strategy for making cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products	1421:1595	This work provides an efficient strategy for making cellulose-based sustainable and functional ionic conductors which have broad application in artificial flexible electronics and other products.
32458678	6	70	theme	multiple	1053:1060	arg1	sensitivity					1062:1072	multiple sensitivity	1053:1072	multiple sensitivity to external stimulus	1053:1093	These materials were demonstrated to possess multiple sensitivity to external stimulus, such as strain, pressure, bend, and temperature.
33459632	4	0	theme	certain	556:562	arg1	microorganisms					575:588	certain intestinal microorganisms	556:588	certain intestinal microorganisms	556:588	In this regard the ability to use oxalate as an energy source by certain intestinal microorganisms has been used as a target form odulators of the intestinal microbiota in order to correcthyperoxaluria, both primary and secondary.
33459632	8	1	theme	lithogenic	1623:1632	arg1	process					1634:1640	the lithogenic process	1619:1640	the lithogenic process	1619:1640	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	1	2	theme	new	169:171	arg1	techniques					196:205	new molecular microbiology techniques	169:205	new molecular microbiology techniques	169:205	Human microbiome understanding and its relationship with health has represented a revolution in biomedicine, facilitated by the emergence of new molecular microbiology techniques.
33459632	10	3	dep	probiotics	1899:1908	arg1	addition					1887:1894	addition	1887:1894	addition	1887:1894	Future therapeutic arsenal, in addition to probiotics and prebiotics, will integrate consortia of different microbial groups and microbiota transplantation, both urinary and intestinal.
33459632	4	4	theme	microbiota	649:658	arg1	odulators					621:629	odulators	621:629	odulators	621:629	In this regard the ability to use oxalate as an energy source by certain intestinal microorganisms has been used as a target form odulators of the intestinal microbiota in order to correcthyperoxaluria, both primary and secondary.
33459632	1	5	theme	microbiology	183:194	arg1	techniques					196:205	new molecular microbiology techniques	169:205	new molecular microbiology techniques	169:205	Human microbiome understanding and its relationship with health has represented a revolution in biomedicine, facilitated by the emergence of new molecular microbiology techniques.
33459632	1	6	with	relationship	67:78	arg1	health					85:90	health	85:90	health	85:90	Human microbiome understanding and its relationship with health has represented a revolution in biomedicine, facilitated by the emergence of new molecular microbiology techniques.
33459632	6	7	theme	tubular	935:941	arg1	lesions					943:949	tubular lesions	935:949	tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level	935:1151	In particular, intestinal microbiome has the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level.
33459632	9	8	theme	binomial	1688:1695	arg1	microbiota					1697:1706	binomial microbiota	1688:1706	binomial microbiota	1688:1706	Associated with the advances in the study of binomial microbiota and lithiasic pathology, new ways are opened for patient management, in terms of prevention and treatment, based on intervention on the microbiome.
33459632	7	9	theme	urine	1362:1366	arg1	sterility					1368:1376	urine sterility	1362:1376	urine sterility in healthy conditions	1362:1398	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	8	10	contain	have	1481:1484	arg1	structure					1455:1463	structure	1455:1463	structure	1455:1463	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	8	10	contain	have	1481:1484	arg1	composition					1439:1449	composition	1439:1449	composition	1439:1449	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	8	10	contain	have	1481:1484	arg2	impact					1496:1501	a crucial impact	1486:1501	a crucial impact	1486:1501	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	10	11	theme	groups	1974:1979	arg1	consortia					1941:1949	consortia	1941:1949	consortia of different microbial groups and microbiota transplantation, both urinary and intestinal	1941:2039	Future therapeutic arsenal, in addition to probiotics and prebiotics, will integrate consortia of different microbial groups and microbiota transplantation, both urinary and intestinal.
33459632	10	12	theme	different	1954:1962	arg1	urinary					2018:2024	urinary	2018:2024	urinary	2018:2024	Future therapeutic arsenal, in addition to probiotics and prebiotics, will integrate consortia of different microbial groups and microbiota transplantation, both urinary and intestinal.
33459632	10	12	theme	different	1954:1962	arg1	intestinal					2030:2039	intestinal	2030:2039	intestinal	2030:2039	Future therapeutic arsenal, in addition to probiotics and prebiotics, will integrate consortia of different microbial groups and microbiota transplantation, both urinary and intestinal.
33459632	10	12	theme	different	1954:1962	arg1	groups					1974:1979	different microbial groups	1954:1979	different microbial groups	1954:1979	Future therapeutic arsenal, in addition to probiotics and prebiotics, will integrate consortia of different microbial groups and microbiota transplantation, both urinary and intestinal.
33459632	9	13	theme	pathology	1722:1730	arg1	study					1679:1683	the study	1675:1683	the study of binomial microbiota and lithiasic pathology	1675:1730	Associated with the advances in the study of binomial microbiota and lithiasic pathology, new ways are opened for patient management, in terms of prevention and treatment, based on intervention on the microbiome.
33459632	2	14	theme	new	255:257	arg1	approach					259:266	this new approach	250:266	this new approach to etiological knowledge	250:291	Lithiasic pathology has not been alien to this new approach to etiological knowledge.
33459632	7	15	from	conditions	1389:1398	arg1	paradigm					1350:1357	the paradigm	1346:1357	the paradigm of urine sterility in healthy conditions	1346:1398	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	9	16	theme	new	1733:1735	arg1	ways					1737:1740	new ways	1733:1740	new ways	1733:1740	Associated with the advances in the study of binomial microbiota and lithiasic pathology, new ways are opened for patient management, in terms of prevention and treatment, based on intervention on the microbiome.
33459632	10	17	theme	microbiota	1985:1994	arg1	transplantation					1996:2010	microbiota transplantation	1985:2010	microbiota transplantation	1985:2010	Future therapeutic arsenal, in addition to probiotics and prebiotics, will integrate consortia of different microbial groups and microbiota transplantation, both urinary and intestinal.
33459632	7	18	with	breaking	1332:1339	arg1	paradigm					1350:1357	the paradigm	1346:1357	the paradigm of urine sterility in healthy conditions	1346:1398	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	6	19	theme	chronic	993:999	arg1	inflammation					1011:1022	chronic low-grade inflammation	993:1022	chronic low-grade inflammation	993:1022	In particular, intestinal microbiome has the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level.
33459632	8	20	theme	urobiome	1472:1479	arg1	structure					1455:1463	structure	1455:1463	structure	1455:1463	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	8	20	theme	urobiome	1472:1479	arg1	composition					1439:1449	composition	1439:1449	composition	1439:1449	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	7	21	theme	microbia	1195:1202	arg1	importance					1158:1167	The importance	1154:1167	The importance of the urobiome	1154:1183	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	7	21	theme	microbia	1195:1202	arg1	lstructure					1204:1213	a stable microbia lstructure	1186:1213	a stable microbia lstructure residing in the urinary tract	1186:1243	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	6	22	theme	oxidative	966:974	arg1	stress					976:981	oxidative stress	966:981	oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level	966:1151	In particular, intestinal microbiome has the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level.
33459632	7	23	theme	urobiome	1176:1183	arg1	lstructure					1204:1213	a stable microbia lstructure	1186:1213	a stable microbia lstructure residing in the urinary tract	1186:1243	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	7	23	theme	urobiome	1176:1183	arg1	importance					1158:1167	The importance	1154:1167	The importance of the urobiome	1154:1183	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	8	24	theme	infectious	1506:1515	arg1	lithiasis					1541:1549	infectious but also non-infectious lithiasis	1506:1549	infectious but also non-infectious lithiasis	1506:1549	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	3	25	theme	activity	323:330	arg1	result					299:304	a result	297:304	a result of this research activity	297:330	As a result of this research activity, it has been possible to elucidate the importance of the intestine-kidney axis, understood as the impact of the intestinal microbiota on nephrourinary health.
33459632	1	26	from	revolution	110:119	arg1	biomedicine					124:134	biomedicine	124:134	biomedicine	124:134	Human microbiome understanding and its relationship with health has represented a revolution in biomedicine, facilitated by the emergence of new molecular microbiology techniques.
33459632	7	27	from	paradigm	1350:1357	arg1	conditions					1389:1398	healthy conditions	1381:1398	healthy conditions	1381:1398	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	5	28	theme	oxalocalcic	794:804	arg1	lithiasis					806:814	oxalocalcic lithiasis	794:814	oxalocalcic lithiasis	794:814	However,the importance of the microbiome configuration, and its role in oxalocalcic lithiasis, transcends the existence of certain trophic networks.
33459632	7	29	theme	urinary	1285:1291	arg1	microorganisms					1293:1306	urinary microorganisms	1285:1306	urinary microorganisms	1285:1306	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	3	30	theme	intestine-kidney	389:404	arg1	axis					406:409	the intestine-kidney axis	385:409	the intestine-kidney axis	385:409	As a result of this research activity, it has been possible to elucidate the importance of the intestine-kidney axis, understood as the impact of the intestinal microbiota on nephrourinary health.
33459632	4	31	theme	energy	539:544	arg1	oxalate					525:531	oxalate	525:531	oxalate	525:531	In this regard the ability to use oxalate as an energy source by certain intestinal microorganisms has been used as a target form odulators of the intestinal microbiota in order to correcthyperoxaluria, both primary and secondary.
33459632	4	31	theme	energy	539:544	arg1	source					546:551	an energy source	536:551	an energy source by certain intestinal microorganisms	536:588	In this regard the ability to use oxalate as an energy source by certain intestinal microorganisms has been used as a target form odulators of the intestinal microbiota in order to correcthyperoxaluria, both primary and secondary.
33459632	5	32	theme	configuration	763:775	arg1	importance					734:743	the importance	730:743	the importance of the microbiome configuration	730:775	However,the importance of the microbiome configuration, and its role in oxalocalcic lithiasis, transcends the existence of certain trophic networks.
33459632	5	32	theme	configuration	763:775	arg1	role					786:789	its role	782:789	its role in oxalocalcic lithiasis	782:814	However,the importance of the microbiome configuration, and its role in oxalocalcic lithiasis, transcends the existence of certain trophic networks.
33459632	8	33	dep	composition	1439:1449	arg1	the					1435:1437	the	1435:1437	the	1435:1437	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	3	34	theme	axis	406:409	arg1	importance					371:380	the importance	367:380	the importance of the intestine-kidney axis, understood as the impact of the intestinal microbiota on nephrourinary health	367:488	As a result of this research activity, it has been possible to elucidate the importance of the intestine-kidney axis, understood as the impact of the intestinal microbiota on nephrourinary health.
33459632	3	35	theme	nephrourinary	469:481	arg1	health					483:488	nephrourinary health	469:488	nephrourinary health	469:488	As a result of this research activity, it has been possible to elucidate the importance of the intestine-kidney axis, understood as the impact of the intestinal microbiota on nephrourinary health.
33459632	6	36	theme	immune	1115:1120	arg1	system					1122:1127	the immune system	1111:1127	the immune system	1111:1127	In particular, intestinal microbiome has the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level.
33459632	2	37	theme	Lithiasic	208:216	arg1	pathology					218:226	Lithiasic pathology	208:226	Lithiasic pathology	208:226	Lithiasic pathology has not been alien to this new approach to etiological knowledge.
33459632	3	38	theme	microbiota	455:464	arg1	impact					430:435	the impact	426:435	the impact of the intestinal microbiota on nephrourinary health	426:488	As a result of this research activity, it has been possible to elucidate the importance of the intestine-kidney axis, understood as the impact of the intestinal microbiota on nephrourinary health.
33459632	8	39	theme	process	1634:1640	arg1	nucleants					1592:1600	nucleants	1592:1600	nucleants	1592:1600	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	8	39	theme	process	1634:1640	arg1	microorganisms					1566:1579	certain microorganisms	1558:1579	certain microorganisms	1558:1579	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	8	39	theme	process	1634:1640	arg1	promoters					1606:1614	promoters	1606:1614	promoters	1606:1614	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	1	40	theme	Human	28:32	arg1	understanding					45:57	Human microbiome understanding	28:57	Human microbiome understanding	28:57	Human microbiome understanding and its relationship with health has represented a revolution in biomedicine, facilitated by the emergence of new molecular microbiology techniques.
33459632	1	41	with	understanding	45:57	arg1	health					85:90	health	85:90	health	85:90	Human microbiome understanding and its relationship with health has represented a revolution in biomedicine, facilitated by the emergence of new molecular microbiology techniques.
33459632	6	42	theme	intestinal	886:895	arg1	microbiome					897:906	intestinal microbiome	886:906	intestinal microbiome	886:906	In particular, intestinal microbiome has the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level.
33459632	6	43	attach	linked	1033:1038	arg2	inflammation					1011:1022	chronic low-grade inflammation	993:1022	chronic low-grade inflammation	993:1022	In particular, intestinal microbiome has the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level.
33459632	6	43	attach	linked	1033:1038	arg1	composition					1047:1057	the composition	1043:1057	the composition of the microbiota	1043:1075	In particular, intestinal microbiome has the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level.
33459632	4	44	theme	intestinal	564:573	arg1	microorganisms					575:588	certain intestinal microorganisms	556:588	certain intestinal microorganisms	556:588	In this regard the ability to use oxalate as an energy source by certain intestinal microorganisms has been used as a target form odulators of the intestinal microbiota in order to correcthyperoxaluria, both primary and secondary.
33459632	6	45	theme	microbiota	1066:1075	arg1	composition					1047:1057	the composition	1043:1057	the composition of the microbiota	1043:1075	In particular, intestinal microbiome has the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level.
33459632	2	46	theme	etiological	271:281	arg1	knowledge					283:291	etiological knowledge	271:291	etiological knowledge	271:291	Lithiasic pathology has not been alien to this new approach to etiological knowledge.
33459632	5	47	theme	certain	845:851	arg1	networks					861:868	certain trophic networks	845:868	certain trophic networks	845:868	However,the importance of the microbiome configuration, and its role in oxalocalcic lithiasis, transcends the existence of certain trophic networks.
33459632	1	48	theme	molecular	173:181	arg1	techniques					196:205	new molecular microbiology techniques	169:205	new molecular microbiology techniques	169:205	Human microbiome understanding and its relationship with health has represented a revolution in biomedicine, facilitated by the emergence of new molecular microbiology techniques.
33459632	6	49	theme	intestinal	1136:1145	arg1	level					1147:1151	the intestinal level	1132:1151	the intestinal level	1132:1151	In particular, intestinal microbiome has the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level.
33459632	6	50	contain	has	908:910	arg1	microbiome					897:906	intestinal microbiome	886:906	intestinal microbiome	886:906	In particular, intestinal microbiome has the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level.
33459632	6	50	contain	has	908:910	arg2	ability					916:922	the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level	912:1151	the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level	912:1151	In particular, intestinal microbiome has the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level.
33459632	4	51	used	used	599:602	arg2	ability					510:516	ability	510:516	ability to use oxalate as an energy source by certain intestinal microorganisms	510:588	In this regard the ability to use oxalate as an energy source by certain intestinal microorganisms has been used as a target form odulators of the intestinal microbiota in order to correcthyperoxaluria, both primary and secondary.
33459632	4	51	used	used	599:602	arg2	target					609:614	a target	607:614	a target form odulators of the intestinal microbiota in order to correcthyperoxaluria, both primary and secondary	607:719	In this regard the ability to use oxalate as an energy source by certain intestinal microorganisms has been used as a target form odulators of the intestinal microbiota in order to correcthyperoxaluria, both primary and secondary.
33459632	1	52	theme	techniques	196:205	arg1	emergence					156:164	the emergence	152:164	the emergence of new molecular microbiology techniques	152:205	Human microbiome understanding and its relationship with health has represented a revolution in biomedicine, facilitated by the emergence of new molecular microbiology techniques.
33459632	7	53	theme	healthy	1381:1387	arg1	conditions					1389:1398	healthy conditions	1381:1398	healthy conditions	1381:1398	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	4	54	theme	intestinal	638:647	arg1	microbiota					649:658	the intestinal microbiota	634:658	the intestinal microbiota in order to correcthyperoxaluria	634:691	In this regard the ability to use oxalate as an energy source by certain intestinal microorganisms has been used as a target form odulators of the intestinal microbiota in order to correcthyperoxaluria, both primary and secondary.
33459632	9	55	theme	microbiota	1697:1706	arg1	study					1679:1683	the study	1675:1683	the study of binomial microbiota and lithiasic pathology	1675:1730	Associated with the advances in the study of binomial microbiota and lithiasic pathology, new ways are opened for patient management, in terms of prevention and treatment, based on intervention on the microbiome.
33459632	7	56	theme	sterility	1368:1376	arg1	paradigm					1350:1357	the paradigm	1346:1357	the paradigm of urine sterility in healthy conditions	1346:1398	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	10	57	theme	microbial	1964:1972	arg1	urinary					2018:2024	urinary	2018:2024	urinary	2018:2024	Future therapeutic arsenal, in addition to probiotics and prebiotics, will integrate consortia of different microbial groups and microbiota transplantation, both urinary and intestinal.
33459632	10	57	theme	microbial	1964:1972	arg1	intestinal					2030:2039	intestinal	2030:2039	intestinal	2030:2039	Future therapeutic arsenal, in addition to probiotics and prebiotics, will integrate consortia of different microbial groups and microbiota transplantation, both urinary and intestinal.
33459632	10	57	theme	microbial	1964:1972	arg1	groups					1974:1979	different microbial groups	1954:1979	different microbial groups	1954:1979	Future therapeutic arsenal, in addition to probiotics and prebiotics, will integrate consortia of different microbial groups and microbiota transplantation, both urinary and intestinal.
33459632	9	58	from	advances	1663:1670	arg1	study					1679:1683	the study	1675:1683	the study of binomial microbiota and lithiasic pathology	1675:1730	Associated with the advances in the study of binomial microbiota and lithiasic pathology, new ways are opened for patient management, in terms of prevention and treatment, based on intervention on the microbiome.
33459632	9	59	theme	lithiasic	1712:1720	arg1	pathology					1722:1730	lithiasic pathology	1712:1730	lithiasic pathology	1712:1730	Associated with the advances in the study of binomial microbiota and lithiasic pathology, new ways are opened for patient management, in terms of prevention and treatment, based on intervention on the microbiome.
33459632	10	60	theme	Future	1856:1861	arg1	arsenal					1875:1881	Future therapeutic arsenal	1856:1881	Future therapeutic arsenal	1856:1881	Future therapeutic arsenal, in addition to probiotics and prebiotics, will integrate consortia of different microbial groups and microbiota transplantation, both urinary and intestinal.
33459632	5	61	theme	trophic	853:859	arg1	networks					861:868	certain trophic networks	845:868	certain trophic networks	845:868	However,the importance of the microbiome configuration, and its role in oxalocalcic lithiasis, transcends the existence of certain trophic networks.
33459632	4	62	theme	primary	699:705	arg1	odulators					621:629	odulators	621:629	odulators	621:629	In this regard the ability to use oxalate as an energy source by certain intestinal microorganisms has been used as a target form odulators of the intestinal microbiota in order to correcthyperoxaluria, both primary and secondary.
33459632	10	63	theme	transplantation	1996:2010	arg1	consortia					1941:1949	consortia	1941:1949	consortia of different microbial groups and microbiota transplantation, both urinary and intestinal	1941:2039	Future therapeutic arsenal, in addition to probiotics and prebiotics, will integrate consortia of different microbial groups and microbiota transplantation, both urinary and intestinal.
33459632	5	64	from	importance	734:743	arg1	lithiasis					806:814	oxalocalcic lithiasis	794:814	oxalocalcic lithiasis	794:814	However,the importance of the microbiome configuration, and its role in oxalocalcic lithiasis, transcends the existence of certain trophic networks.
33459632	5	65	theme	networks	861:868	arg1	existence					832:840	the existence	828:840	the existence of certain trophic networks	828:868	However,the importance of the microbiome configuration, and its role in oxalocalcic lithiasis, transcends the existence of certain trophic networks.
33459632	6	66	theme	low-grade	1001:1009	arg1	inflammation					1011:1022	chronic low-grade inflammation	993:1022	chronic low-grade inflammation	993:1022	In particular, intestinal microbiome has the ability to promote tubular lesions resulting from oxidative stress caused by chronic low-grade inflammation, closely linked to the composition of the microbiota and the dialogue established with the immune system at the intestinal level.
33459632	7	67	theme	stable	1188:1193	arg1	importance					1158:1167	The importance	1154:1167	The importance of the urobiome	1154:1183	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	7	67	theme	stable	1188:1193	arg1	lstructure					1204:1213	a stable microbia lstructure	1186:1213	a stable microbia lstructure residing in the urinary tract	1186:1243	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	3	68	theme	research	314:321	arg1	activity					323:330	this research activity	309:330	this research activity	309:330	As a result of this research activity, it has been possible to elucidate the importance of the intestine-kidney axis, understood as the impact of the intestinal microbiota on nephrourinary health.
33459632	8	69	theme	crucial	1488:1494	arg1	impact					1496:1501	a crucial impact	1486:1501	a crucial impact	1486:1501	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	4	70	dep	ability	510:516	arg1	use					521:523	use	521:523	to use oxalate as an energy source by certain intestinal microorganisms	518:588	In this regard the ability to use oxalate as an energy source by certain intestinal microorganisms has been used as a target form odulators of the intestinal microbiota in order to correcthyperoxaluria, both primary and secondary.
33459632	9	71	theme	patient	1757:1763	arg1	management					1765:1774	patient management	1757:1774	patient management	1757:1774	Associated with the advances in the study of binomial microbiota and lithiasic pathology, new ways are opened for patient management, in terms of prevention and treatment, based on intervention on the microbiome.
33459632	7	72	theme	lithiasic	1311:1319	arg1	breaking					1332:1339	breaking	1332:1339	breaking with the paradigm of urine sterility in healthy conditions	1332:1398	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	7	72	theme	lithiasic	1311:1319	arg1	pathology					1321:1329	lithiasic pathology	1311:1329	lithiasic pathology	1311:1329	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	5	73	from	role	786:789	arg1	lithiasis					806:814	oxalocalcic lithiasis	794:814	oxalocalcic lithiasis	794:814	However,the importance of the microbiome configuration, and its role in oxalocalcic lithiasis, transcends the existence of certain trophic networks.
33459632	7	74	theme	microorganisms	1293:1306	arg1	importance					1271:1280	the importance	1267:1280	the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions	1267:1398	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	8	75	theme	non-infectious	1526:1539	arg1	lithiasis					1541:1549	infectious but also non-infectious lithiasis	1506:1549	infectious but also non-infectious lithiasis	1506:1549	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	4	76	theme	secondary	711:719	arg1	odulators					621:629	odulators	621:629	odulators	621:629	In this regard the ability to use oxalate as an energy source by certain intestinal microorganisms has been used as a target form odulators of the intestinal microbiota in order to correcthyperoxaluria, both primary and secondary.
33459632	9	77	theme	prevention	1789:1798	arg1	terms					1780:1784	terms	1780:1784	terms	1780:1784	Associated with the advances in the study of binomial microbiota and lithiasic pathology, new ways are opened for patient management, in terms of prevention and treatment, based on intervention on the microbiome.
33459632	3	78	theme	intestinal	444:453	arg1	microbiota					455:464	the intestinal microbiota	440:464	the intestinal microbiota	440:464	As a result of this research activity, it has been possible to elucidate the importance of the intestine-kidney axis, understood as the impact of the intestinal microbiota on nephrourinary health.
33459632	5	79	theme	microbiome	752:761	arg1	configuration					763:775	the microbiome configuration	748:775	the microbiome configuration	748:775	However,the importance of the microbiome configuration, and its role in oxalocalcic lithiasis, transcends the existence of certain trophic networks.
33459632	7	80	from	sterility	1368:1376	arg1	conditions					1389:1398	healthy conditions	1381:1398	healthy conditions	1381:1398	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	9	81	theme	treatment	1804:1812	arg1	terms					1780:1784	terms	1780:1784	terms	1780:1784	Associated with the advances in the study of binomial microbiota and lithiasic pathology, new ways are opened for patient management, in terms of prevention and treatment, based on intervention on the microbiome.
33459632	8	82	theme	certain	1558:1564	arg1	nucleants					1592:1600	nucleants	1592:1600	nucleants	1592:1600	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	8	82	theme	certain	1558:1564	arg1	microorganisms					1566:1579	certain microorganisms	1558:1579	certain microorganisms	1558:1579	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	8	82	theme	certain	1558:1564	arg1	promoters					1606:1614	promoters	1606:1614	promoters	1606:1614	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33459632	3	83	from	impact	430:435	arg1	health					483:488	nephrourinary health	469:488	nephrourinary health	469:488	As a result of this research activity, it has been possible to elucidate the importance of the intestine-kidney axis, understood as the impact of the intestinal microbiota on nephrourinary health.
33459632	7	84	from	importance	1271:1280	arg1	breaking					1332:1339	breaking	1332:1339	breaking with the paradigm of urine sterility in healthy conditions	1332:1398	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	7	84	from	importance	1271:1280	arg1	pathology					1321:1329	lithiasic pathology	1311:1329	lithiasic pathology	1311:1329	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	10	85	theme	therapeutic	1863:1873	arg1	arsenal					1875:1881	Future therapeutic arsenal	1856:1881	Future therapeutic arsenal	1856:1881	Future therapeutic arsenal, in addition to probiotics and prebiotics, will integrate consortia of different microbial groups and microbiota transplantation, both urinary and intestinal.
33459632	1	86	theme	microbiome	34:43	arg1	understanding					45:57	Human microbiome understanding	28:57	Human microbiome understanding	28:57	Human microbiome understanding and its relationship with health has represented a revolution in biomedicine, facilitated by the emergence of new molecular microbiology techniques.
33459632	7	87	theme	urinary	1231:1237	arg1	tract					1239:1243	the urinary tract	1227:1243	the urinary tract	1227:1243	The importance of the urobiome, a stable microbia lstructure residing in the urinary tract, allowed to calibrate the importance of urinary microorganisms in lithiasic pathology, breaking with the paradigm of urine sterility in healthy conditions.
33459632	8	88	theme	recent	1407:1412	arg1	studies					1414:1420	recent studies	1407:1420	recent studies	1407:1420	Thus, recent studies suggest that the composition and structure of the urobiome have a crucial impact on infectious but also non-infectious lithiasis, since certain microorganisms can act as nucleants and promoters of the lithogenic process.
33964114	1	0	theme	complexes	326:334	arg1	properties					308:317	the properties	304:317	the properties of the complexes including composition, particle diameter, and zeta potential	304:395	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	4	1	dep	properties	926:935	arg1	size					938:941	size	938:941	size	938:941	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
33964114	4	1	dep	properties	926:935	arg1	strength					950:957	ionic strength	944:957	ionic strength	944:957	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
33964114	2	2	theme	serum	459:463	arg1	albumin					465:471	bovine serum albumin	452:471	bovine serum albumin	452:471	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	2	3	theme	density	569:575	arg1	effect					540:545	the effect	536:545	the effect of crosslinker charge density on protein release kinetics	536:603	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	5	4	contain	has	1169:1171	arg2	potential					1177:1185	the potential to be used for optimization of the complexes and prediction of physical properties and degradation rates	1173:1290	the potential to be used for optimization of the complexes and prediction of physical properties and degradation rates	1173:1290	The multivariate statistical has the potential to be used for optimization of the complexes and prediction of physical properties and degradation rates.
33964114	5	4	contain	has	1169:1171	arg1	statistical					1157:1167	statistical	1157:1167	statistical	1157:1167	The multivariate statistical has the potential to be used for optimization of the complexes and prediction of physical properties and degradation rates.
33964114	3	5	dep	surprisingly	734:745	arg1	not					730:732	not	730:732	not	730:732	Multivariate statistical analysis showed that the kinetic parameters associated with the release were, not surprisingly highly dependent on the ionic strength of the release media, with higher ionic strength leading to faster release.
33964114	2	6	theme	charge	562:567	arg1	density					569:575	crosslinker charge density	550:575	crosslinker charge density	550:575	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	3	7	theme	faster	846:851	arg1	release					853:859	faster release	846:859	faster release	846:859	Multivariate statistical analysis showed that the kinetic parameters associated with the release were, not surprisingly highly dependent on the ionic strength of the release media, with higher ionic strength leading to faster release.
33964114	1	8	theme	ionic	260:264	arg1	composition					266:276	ionic composition	260:276	ionic composition	260:276	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	5	9	theme	properties	1259:1268	arg1	prediction					1236:1245	prediction	1236:1245	prediction of physical properties and degradation rates	1236:1290	The multivariate statistical has the potential to be used for optimization of the complexes and prediction of physical properties and degradation rates.
33964114	5	9	theme	properties	1259:1268	arg1	optimization					1202:1213	optimization	1202:1213	optimization of the complexes	1202:1230	The multivariate statistical has the potential to be used for optimization of the complexes and prediction of physical properties and degradation rates.
33964114	2	10	theme	crosslinker	550:560	arg1	density					569:575	crosslinker charge density	550:575	crosslinker charge density	550:575	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	2	11	from	effect	540:545	arg1	kinetics					596:603	protein release kinetics	580:603	protein release kinetics	580:603	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	4	12	theme	protein	918:924	arg1	properties					926:935	the protein properties	914:935	the protein properties (size, ionic strength)	914:958	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
33964114	1	13	theme	particle	359:366	arg1	diameter					368:375	particle diameter	359:375	particle diameter	359:375	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	1	14	theme	Statistical	93:103	arg1	methods					105:111	Statistical methods	93:111	Statistical methods	93:111	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	5	15	theme	degradation	1274:1284	arg1	rates					1286:1290	degradation rates	1274:1290	degradation rates	1274:1290	The multivariate statistical has the potential to be used for optimization of the complexes and prediction of physical properties and degradation rates.
33964114	3	16	theme	release	793:799	arg1	media					801:805	the release media	789:805	the release media	789:805	Multivariate statistical analysis showed that the kinetic parameters associated with the release were, not surprisingly highly dependent on the ionic strength of the release media, with higher ionic strength leading to faster release.
33964114	3	17	theme	media	801:805	arg1	strength					777:784	the ionic strength	767:784	the ionic strength of the release media	767:805	Multivariate statistical analysis showed that the kinetic parameters associated with the release were, not surprisingly highly dependent on the ionic strength of the release media, with higher ionic strength leading to faster release.
33964114	5	18	theme	rates	1286:1290	arg1	prediction					1236:1245	prediction	1236:1245	prediction of physical properties and degradation rates	1236:1290	The multivariate statistical has the potential to be used for optimization of the complexes and prediction of physical properties and degradation rates.
33964114	5	18	theme	rates	1286:1290	arg1	optimization					1202:1213	optimization	1202:1213	optimization of the complexes	1202:1230	The multivariate statistical has the potential to be used for optimization of the complexes and prediction of physical properties and degradation rates.
33964114	2	19	theme	release	588:594	arg1	kinetics					596:603	protein release kinetics	580:603	protein release kinetics	580:603	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	0	20	theme	Property	0:7	arg1	modelling					9:17	Property modelling	0:17	Property modelling of lysozyme-crosslinker-alginate complexes	0:60	Property modelling of lysozyme-crosslinker-alginate complexes using latent variable methods.
33964114	2	21	theme	protein	580:586	arg1	kinetics					596:603	protein release kinetics	580:603	protein release kinetics	580:603	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	2	22	used	used	480:483	arg2	crosslinkers					406:417	Various crosslinkers	398:417	Various crosslinkers (calcium, barium, iron[III]	398:445	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	2	22	used	used	480:483	arg2	albumin					465:471	bovine serum albumin	452:471	bovine serum albumin	452:471	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	0	23	theme	lysozyme-crosslinker-alginate	22:50	arg1	complexes					52:60	lysozyme-crosslinker-alginate complexes	22:60	lysozyme-crosslinker-alginate complexes	22:60	Property modelling of lysozyme-crosslinker-alginate complexes using latent variable methods.
33964114	1	24	theme	mixing	285:290	arg1	solution					292:299	the mixing solution	281:299	the mixing solution	281:299	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	5	25	theme	complexes	1222:1230	arg1	prediction					1236:1245	prediction	1236:1245	prediction of physical properties and degradation rates	1236:1290	The multivariate statistical has the potential to be used for optimization of the complexes and prediction of physical properties and degradation rates.
33964114	5	25	theme	complexes	1222:1230	arg1	optimization					1202:1213	optimization	1202:1213	optimization of the complexes	1202:1230	The multivariate statistical has the potential to be used for optimization of the complexes and prediction of physical properties and degradation rates.
33964114	4	26	theme	crosslinker	1043:1053	arg1	density					1028:1034	the charge density	1017:1034	the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release	1017:1137	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
33964114	5	27	theme	physical	1250:1257	arg1	properties					1259:1268	physical properties	1250:1268	physical properties	1250:1268	The multivariate statistical has the potential to be used for optimization of the complexes and prediction of physical properties and degradation rates.
33964114	2	28	theme	bovine	452:457	arg1	albumin					465:471	bovine serum albumin	452:471	bovine serum albumin	452:471	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	1	29	theme	solution	292:299	arg1	pH					252:253	pH	252:253	pH	252:253	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	1	29	theme	solution	292:299	arg1	composition					266:276	ionic composition	260:276	ionic composition	260:276	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	2	30	theme	complex	503:509	arg1	formation					511:519	complex formation	503:519	complex formation	503:519	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	1	31	theme	zeta	382:385	arg1	potential					387:395	zeta potential	382:395	zeta potential	382:395	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	2	32	dep	crosslinkers	406:417	arg1	iron[III					437:444	iron[III	437:444	iron[III	437:444	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	2	32	dep	crosslinkers	406:417	arg1	barium					429:434	barium	429:434	barium	429:434	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	2	32	dep	crosslinkers	406:417	arg1	calcium					420:426	calcium	420:426	calcium	420:426	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	4	33	theme	charge	1021:1026	arg1	density					1028:1034	the charge density	1017:1034	the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release	1017:1137	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
33964114	0	34	theme	complexes	52:60	arg1	modelling					9:17	Property modelling	0:17	Property modelling of lysozyme-crosslinker-alginate complexes	0:60	Property modelling of lysozyme-crosslinker-alginate complexes using latent variable methods.
33964114	4	35	theme	ionic	944:948	arg1	size					938:941	size	938:941	size	938:941	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
33964114	4	35	theme	ionic	944:948	arg1	strength					950:957	ionic strength	944:957	ionic strength	944:957	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
33964114	1	36	from	effects	222:228	arg1	properties					308:317	the properties	304:317	the properties of the complexes including composition, particle diameter, and zeta potential	304:395	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	2	37	theme	Various	398:404	arg1	crosslinkers					406:417	Various crosslinkers	398:417	Various crosslinkers (calcium, barium, iron[III]	398:445	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	0	38	theme	variable	75:82	arg1	methods					84:90	latent variable methods	68:90	latent variable methods	68:90	Property modelling of lysozyme-crosslinker-alginate complexes using latent variable methods.
33964114	4	39	theme	release	866:872	arg1	k					884:884	The release parameter k	862:884	The release parameter k	862:884	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
33964114	0	40	theme	latent	68:73	arg1	methods					84:90	latent variable methods	68:90	latent variable methods	68:90	Property modelling of lysozyme-crosslinker-alginate complexes using latent variable methods.
33964114	4	41	theme	drug	1126:1129	arg1	release					1131:1137	drug release	1126:1137	drug release	1126:1137	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
33964114	1	42	used	used	118:121	arg2	methods					105:111	Statistical methods	93:111	Statistical methods	93:111	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	1	43	theme	such	233:236	arg1	parameters					238:247	such parameters	233:247	such parameters as pH, and ionic composition of the mixing solution	233:299	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	4	44	theme	parameter	874:882	arg1	k					884:884	The release parameter k	862:884	The release parameter k	862:884	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
33964114	3	45	theme	Multivariate	627:638	arg1	analysis					652:659	Multivariate statistical analysis	627:659	Multivariate statistical analysis	627:659	Multivariate statistical analysis showed that the kinetic parameters associated with the release were, not surprisingly highly dependent on the ionic strength of the release media, with higher ionic strength leading to faster release.
33964114	4	46	theme	crosslinker	1092:1102	arg1	nature					1078:1083	the nature	1074:1083	the nature of the crosslinker	1074:1102	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
33964114	1	47	theme	polymer	149:155	arg1	system					165:170	a polymer complex system	147:170	a polymer complex system composed of lysozyme and alginate	147:204	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	3	48	theme	higher	813:818	arg1	strength					826:833	higher ionic strength	813:833	higher ionic strength	813:833	Multivariate statistical analysis showed that the kinetic parameters associated with the release were, not surprisingly highly dependent on the ionic strength of the release media, with higher ionic strength leading to faster release.
33964114	1	49	theme	parameters	238:247	arg1	effects					222:228	the effects	218:228	the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential	218:395	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	4	50	contain	had	1104:1106	arg1	nature					1078:1083	the nature	1074:1083	the nature of the crosslinker	1074:1102	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
33964114	4	50	contain	had	1104:1106	arg2	impact					1116:1121	minimal impact	1108:1121	minimal impact	1108:1121	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
33964114	3	51	theme	statistical	640:650	arg1	analysis					652:659	Multivariate statistical analysis	627:659	Multivariate statistical analysis	627:659	Multivariate statistical analysis showed that the kinetic parameters associated with the release were, not surprisingly highly dependent on the ionic strength of the release media, with higher ionic strength leading to faster release.
33964114	1	52	theme	complex	157:163	arg1	system					165:170	a polymer complex system	147:170	a polymer complex system composed of lysozyme and alginate	147:204	Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential.
33964114	3	53	theme	ionic	820:824	arg1	strength					826:833	higher ionic strength	813:833	higher ionic strength	813:833	Multivariate statistical analysis showed that the kinetic parameters associated with the release were, not surprisingly highly dependent on the ionic strength of the release media, with higher ionic strength leading to faster release.
33964114	3	54	theme	ionic	771:775	arg1	strength					777:784	the ionic strength	767:784	the ionic strength of the release media	767:805	Multivariate statistical analysis showed that the kinetic parameters associated with the release were, not surprisingly highly dependent on the ionic strength of the release media, with higher ionic strength leading to faster release.
33964114	2	55	dep	investigate	524:534	arg1	modelled					606:613	modelled	606:613	modelled using ktn	606:623	Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn .
33964114	3	56	theme	kinetic	677:683	arg1	dependent					754:762	dependent	754:762	dependent	754:762	Multivariate statistical analysis showed that the kinetic parameters associated with the release were, not surprisingly highly dependent on the ionic strength of the release media, with higher ionic strength leading to faster release.
33964114	3	56	theme	kinetic	677:683	arg1	parameters					685:694	the kinetic parameters	673:694	the kinetic parameters associated with the release	673:722	Multivariate statistical analysis showed that the kinetic parameters associated with the release were, not surprisingly highly dependent on the ionic strength of the release media, with higher ionic strength leading to faster release.
33964114	4	57	theme	minimal	1108:1114	arg1	impact					1116:1121	minimal impact	1108:1121	minimal impact	1108:1121	The release parameter k was also shown to depend on the protein properties (size, ionic strength) while n was slightly, but not statistically dependent on the charge density of the crosslinker demonstrating that the nature of the crosslinker had minimal impact on drug release.
34664579	0	0	theme	L.	82:83	arg1	var					85:87	Citrus medica L. var	68:87	Citrus medica L. var	68:87	Enzymatic extraction of pectic oligosaccharides from finger citron (Citrus medica L. var.
34664579	4	1	theme	mL-1	623:626	arg1	pectin					628:633	50 mg mL-1 pectin	617:633	50 mg mL-1 pectin	617:633	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	0	2	from	citron	60:65	arg1	extraction					10:19	Enzymatic extraction	0:19	Enzymatic extraction of pectic oligosaccharides from finger citron (Citrus medica L. var.	0:88	Enzymatic extraction of pectic oligosaccharides from finger citron (Citrus medica L. var.
34664579	4	3	theme	orthogonal	444:453	arg1	OED					474:476	OED	474:476	OED	474:476	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	4	3	theme	orthogonal	444:453	arg1	design					466:471	the orthogonal experiment design	440:471	the orthogonal experiment design (OED)	440:477	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	0	4	theme	medica	75:80	arg1	var					85:87	Citrus medica L. var	68:87	Citrus medica L. var	68:87	Enzymatic extraction of pectic oligosaccharides from finger citron (Citrus medica L. var.
34664579	4	5	theme	mg	620:621	arg1	pectin					628:633	50 mg mL-1 pectin	617:633	50 mg mL-1 pectin	617:633	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	4	6	theme	%	521:521	arg1	rate					503:506	the maximum conversion rate	480:506	the maximum conversion rate of up to 64.5% from pomace to POS	480:540	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	3	7	theme	ultrasonic-assisted	322:340	arg1	method					342:347	a pectinase-based and ultrasonic-assisted method	300:347	a pectinase-based and ultrasonic-assisted method	300:347	In this study, a pectinase-based and ultrasonic-assisted method was firstly used to extract pectic oligosaccharides (POS) from finger citron pomace.
34664579	7	8	theme	effective	1177:1185	arg1	antioxidant					1195:1205	an effective natural antioxidant	1174:1205	an effective natural antioxidant for applications in the food and pharmaceutical industries	1174:1264	FCPOS-1 has the potential to be an effective natural antioxidant for applications in the food and pharmaceutical industries.
34664579	5	9	theme	FTIR	844:847	arg1	analyses					804:811	the analyses	800:811	the analyses of monosaccharide composition, FTIR, NMR and ESI-MS	800:863	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	4	10	from	pomace	528:533	arg1	%					521:521	up to 64.5%	511:521	up to 64.5% from pomace	511:533	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	4	10	from	pomace	528:533	arg1	rate					503:506	the maximum conversion rate	480:506	the maximum conversion rate of up to 64.5% from pomace to POS	480:540	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	2	11	theme	citron	155:160	arg1	pomace					162:167	Finger citron pomace	148:167	Finger citron pomace	148:167	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	2	11	theme	citron	155:160	arg1	by-product					194:203	a cheap and renewable by-product	172:203	a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass	172:282	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	6	12	contain	possessed	1030:1038	arg1	FCPOS-1					1022:1028	FCPOS-1	1022:1028	FCPOS-1	1022:1028	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	6	12	contain	possessed	1030:1038	arg2	properties					1063:1072	remarkable antioxidant properties	1040:1072	remarkable antioxidant properties	1040:1072	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	6	12	contain	possessed	1030:1038	arg2	activity					1097:1104	scavenging activity	1086:1104	scavenging activity against DPPH radicals up to 94.07%	1086:1139	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	3	13	theme	pectinase-based	302:316	arg1	method					342:347	a pectinase-based and ultrasonic-assisted method	300:347	a pectinase-based and ultrasonic-assisted method	300:347	In this study, a pectinase-based and ultrasonic-assisted method was firstly used to extract pectic oligosaccharides (POS) from finger citron pomace.
34664579	2	14	theme	Finger	148:153	arg1	pomace					162:167	Finger citron pomace	148:167	Finger citron pomace	148:167	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	2	14	theme	Finger	148:153	arg1	by-product					194:203	a cheap and renewable by-product	172:203	a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass	172:282	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	7	15	theme	natural	1187:1193	arg1	antioxidant					1195:1205	an effective natural antioxidant	1174:1205	an effective natural antioxidant for applications in the food and pharmaceutical industries	1174:1264	FCPOS-1 has the potential to be an effective natural antioxidant for applications in the food and pharmaceutical industries.
34664579	5	16	theme	NMR	850:852	arg1	analyses					804:811	the analyses	800:811	the analyses of monosaccharide composition, FTIR, NMR and ESI-MS	800:863	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	4	17	theme	mg	595:596	arg1	pectinase					603:611	0.25 mg mL-1 pectinase	590:611	0.25 mg mL-1 pectinase	590:611	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	3	18	theme	pectic	377:382	arg1	POS					402:404	POS	402:404	POS	402:404	In this study, a pectinase-based and ultrasonic-assisted method was firstly used to extract pectic oligosaccharides (POS) from finger citron pomace.
34664579	3	18	theme	pectic	377:382	arg1	oligosaccharides					384:399	pectic oligosaccharides	377:399	pectic oligosaccharides (POS)	377:405	In this study, a pectinase-based and ultrasonic-assisted method was firstly used to extract pectic oligosaccharides (POS) from finger citron pomace.
34664579	5	19	theme	kDa	791:793	arg1	weight					776:781	a molecular weight	764:781	a molecular weight of 2.15 kDa	764:793	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	20	theme	extracted	668:676	arg1	POS					678:680	The extracted POS	664:680	The extracted POS	664:680	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	6	21	theme	remarkable	1040:1049	arg1	activity					1097:1104	scavenging activity	1086:1104	scavenging activity against DPPH radicals up to 94.07%	1086:1139	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	6	21	theme	remarkable	1040:1049	arg1	properties					1063:1072	remarkable antioxidant properties	1040:1072	remarkable antioxidant properties	1040:1072	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	4	22	dep	64.5	517:520	arg1	to					514:515	to	514:515	to	514:515	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	3	23	theme	finger	412:417	arg1	pomace					426:431	finger citron pomace	412:431	finger citron pomace	412:431	In this study, a pectinase-based and ultrasonic-assisted method was firstly used to extract pectic oligosaccharides (POS) from finger citron pomace.
34664579	4	24	theme	experiment	455:464	arg1	OED					474:476	OED	474:476	OED	474:476	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	4	24	theme	experiment	455:464	arg1	design					466:471	the orthogonal experiment design	440:471	the orthogonal experiment design (OED)	440:477	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	6	25	dep	%	1139:1139	arg1	up					1128:1129	up	1128:1129	up	1128:1129	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	7	26	contain	has	1150:1152	arg2	potential					1158:1166	the potential to be an effective natural antioxidant for applications in the food and pharmaceutical industries	1154:1264	the potential to be an effective natural antioxidant for applications in the food and pharmaceutical industries	1154:1264	FCPOS-1 has the potential to be an effective natural antioxidant for applications in the food and pharmaceutical industries.
34664579	7	26	contain	has	1150:1152	arg1	FCPOS-1					1142:1148	FCPOS-1	1142:1148	FCPOS-1	1142:1148	FCPOS-1 has the potential to be an effective natural antioxidant for applications in the food and pharmaceutical industries.
34664579	4	27	theme	pectinase	603:611	arg1	conditions					576:585	the extraction conditions	561:585	the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin	561:633	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	0	28	theme	Enzymatic	0:8	arg1	extraction					10:19	Enzymatic extraction	0:19	Enzymatic extraction of pectic oligosaccharides from finger citron (Citrus medica L. var.	0:88	Enzymatic extraction of pectic oligosaccharides from finger citron (Citrus medica L. var.
34664579	5	29	theme	monosaccharide	816:829	arg1	composition					831:841	monosaccharide composition	816:841	monosaccharide composition	816:841	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	4	30	theme	mL-1	598:601	arg1	pectinase					603:611	0.25 mg mL-1 pectinase	590:611	0.25 mg mL-1 pectinase	590:611	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	0	31	theme	pectic	24:29	arg1	oligosaccharides					31:46	pectic oligosaccharides	24:46	pectic oligosaccharides	24:46	Enzymatic extraction of pectic oligosaccharides from finger citron (Citrus medica L. var.
34664579	7	32	theme	food	1231:1234	arg1	industries					1255:1264	the food and pharmaceutical industries	1227:1264	the food and pharmaceutical industries	1227:1264	FCPOS-1 has the potential to be an effective natural antioxidant for applications in the food and pharmaceutical industries.
34664579	2	33	theme	biomass	276:282	arg1	biomass					276:282	the fruit biomass	266:282	the fruit biomass	266:282	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	2	33	theme	biomass	276:282	arg1	%					261:261	up to 60%	253:261	up to 60% of the fruit biomass	253:282	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	2	34	theme	industry	230:237	arg1	pomace					162:167	Finger citron pomace	148:167	Finger citron pomace	148:167	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	2	34	theme	industry	230:237	arg1	by-product					194:203	a cheap and renewable by-product	172:203	a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass	172:282	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	4	35	theme	extraction	565:574	arg1	conditions					576:585	the extraction conditions	561:585	the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin	561:633	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	6	36	theme	activity	983:990	arg1	assays					992:997	Multiple antioxidant activity assays	962:997	Multiple antioxidant activity assays in vitro	962:1006	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	6	37	theme	antioxidant	1051:1061	arg1	activity					1097:1104	scavenging activity	1086:1104	scavenging activity against DPPH radicals up to 94.07%	1086:1139	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	6	37	theme	antioxidant	1051:1061	arg1	properties					1063:1072	remarkable antioxidant properties	1040:1072	remarkable antioxidant properties	1040:1072	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	2	38	theme	cheap	174:178	arg1	pomace					162:167	Finger citron pomace	148:167	Finger citron pomace	148:167	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	2	38	theme	cheap	174:178	arg1	by-product					194:203	a cheap and renewable by-product	172:203	a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass	172:282	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	2	39	theme	fruit	270:274	arg1	biomass					276:282	the fruit biomass	266:282	the fruit biomass	266:282	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	6	40	theme	antioxidant	971:981	arg1	assays					992:997	Multiple antioxidant activity assays	962:997	Multiple antioxidant activity assays in vitro	962:1006	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	4	41	from	rate	503:506	arg1	pomace					528:533	pomace	528:533	pomace	528:533	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	6	42	theme	in	999:1000	arg1	assays					992:997	Multiple antioxidant activity assays	962:997	Multiple antioxidant activity assays in vitro	962:1006	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	0	43	dep	citron	60:65	arg1	var					85:87	Citrus medica L. var	68:87	Citrus medica L. var	68:87	Enzymatic extraction of pectic oligosaccharides from finger citron (Citrus medica L. var.
34664579	5	44	theme	molecular	766:774	arg1	weight					776:781	a molecular weight	764:781	a molecular weight of 2.15 kDa	764:793	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	3	45	theme	citron	419:424	arg1	pomace					426:431	finger citron pomace	412:431	finger citron pomace	412:431	In this study, a pectinase-based and ultrasonic-assisted method was firstly used to extract pectic oligosaccharides (POS) from finger citron pomace.
34664579	0	46	theme	oligosaccharides	31:46	arg1	extraction					10:19	Enzymatic extraction	0:19	Enzymatic extraction of pectic oligosaccharides from finger citron (Citrus medica L. var.	0:88	Enzymatic extraction of pectic oligosaccharides from finger citron (Citrus medica L. var.
34664579	4	47	theme	maximum	484:490	arg1	rate					503:506	the maximum conversion rate	480:506	the maximum conversion rate of up to 64.5% from pomace to POS	480:540	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	3	48	used	used	361:364	arg2	method					342:347	a pectinase-based and ultrasonic-assisted method	300:347	a pectinase-based and ultrasonic-assisted method	300:347	In this study, a pectinase-based and ultrasonic-assisted method was firstly used to extract pectic oligosaccharides (POS) from finger citron pomace.
34664579	5	49	theme	galactose	937:945	arg1	amount					918:923	a small amount	910:923	a small amount of mannose, galactose and arabinose	910:959	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	49	theme	galactose	937:945	arg1	galactose					937:945	galactose	937:945	galactose	937:945	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	49	theme	galactose	937:945	arg1	arabinose					951:959	arabinose	951:959	arabinose	951:959	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	49	theme	galactose	937:945	arg1	GalA					901:904	GalA	901:904	GalA	901:904	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	49	theme	galactose	937:945	arg1	mannose					928:934	mannose	928:934	mannose	928:934	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	2	50	theme	processing	219:228	arg1	industry					230:237	the citrus processing industry	208:237	the citrus processing industry	208:237	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	5	51	theme	mannose	928:934	arg1	amount					918:923	a small amount	910:923	a small amount of mannose, galactose and arabinose	910:959	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	51	theme	mannose	928:934	arg1	galactose					937:945	galactose	937:945	galactose	937:945	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	51	theme	mannose	928:934	arg1	arabinose					951:959	arabinose	951:959	arabinose	951:959	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	51	theme	mannose	928:934	arg1	GalA					901:904	GalA	901:904	GalA	901:904	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	51	theme	mannose	928:934	arg1	mannose					928:934	mannose	928:934	mannose	928:934	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	52	theme	arabinose	951:959	arg1	amount					918:923	a small amount	910:923	a small amount of mannose, galactose and arabinose	910:959	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	52	theme	arabinose	951:959	arg1	galactose					937:945	galactose	937:945	galactose	937:945	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	52	theme	arabinose	951:959	arg1	arabinose					951:959	arabinose	951:959	arabinose	951:959	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	52	theme	arabinose	951:959	arg1	GalA					901:904	GalA	901:904	GalA	901:904	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	52	theme	arabinose	951:959	arg1	mannose					928:934	mannose	928:934	mannose	928:934	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	2	53	theme	citrus	212:217	arg1	industry					230:237	the citrus processing industry	208:237	the citrus processing industry	208:237	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	3	54	from	pomace	426:431	arg1	extract					369:375	extract	369:375	extract	369:375	In this study, a pectinase-based and ultrasonic-assisted method was firstly used to extract pectic oligosaccharides (POS) from finger citron pomace.
34664579	0	55	theme	finger	53:58	arg1	citron					60:65	finger citron	53:65	finger citron (Citrus medica L. var	53:87	Enzymatic extraction of pectic oligosaccharides from finger citron (Citrus medica L. var.
34664579	6	56	theme	DPPH	1114:1117	arg1	radicals					1119:1126	DPPH radicals	1114:1126	DPPH radicals	1114:1126	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	4	57	theme	pectin	628:633	arg1	conditions					576:585	the extraction conditions	561:585	the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin	561:633	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	4	58	theme	conversion	492:501	arg1	rate					503:506	the maximum conversion rate	480:506	the maximum conversion rate of up to 64.5% from pomace to POS	480:540	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	5	59	theme	small	912:916	arg1	amount					918:923	a small amount	910:923	a small amount of mannose, galactose and arabinose	910:959	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	59	theme	small	912:916	arg1	arabinose					951:959	arabinose	951:959	arabinose	951:959	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	59	theme	small	912:916	arg1	galactose					937:945	galactose	937:945	galactose	937:945	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	59	theme	small	912:916	arg1	mannose					928:934	mannose	928:934	mannose	928:934	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	60	theme	ESI-MS	858:863	arg1	analyses					804:811	the analyses	800:811	the analyses of monosaccharide composition, FTIR, NMR and ESI-MS	800:863	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	61	theme	composition	831:841	arg1	analyses					804:811	the analyses	800:811	the analyses of monosaccharide composition, FTIR, NMR and ESI-MS	800:863	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	2	62	theme	renewable	184:192	arg1	pomace					162:167	Finger citron pomace	148:167	Finger citron pomace	148:167	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	2	62	theme	renewable	184:192	arg1	by-product					194:203	a cheap and renewable by-product	172:203	a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass	172:282	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
34664579	7	63	theme	pharmaceutical	1240:1253	arg1	industries					1255:1264	the food and pharmaceutical industries	1227:1264	the food and pharmaceutical industries	1227:1264	FCPOS-1 has the potential to be an effective natural antioxidant for applications in the food and pharmaceutical industries.
34664579	1	64	theme	antioxidant	125:135	arg1	potential					137:145	antioxidant potential	125:145	antioxidant potential	125:145	sarcodactylis Swingle) pomace with antioxidant potential.
34664579	0	65	theme	Citrus	68:73	arg1	var					85:87	Citrus medica L. var	68:87	Citrus medica L. var	68:87	Enzymatic extraction of pectic oligosaccharides from finger citron (Citrus medica L. var.
34664579	6	66	theme	Multiple	962:969	arg1	assays					992:997	Multiple antioxidant activity assays	962:997	Multiple antioxidant activity assays in vitro	962:1006	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	6	67	theme	scavenging	1086:1095	arg1	activity					1097:1104	scavenging activity	1086:1104	scavenging activity against DPPH radicals up to 94.07%	1086:1139	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	6	67	theme	scavenging	1086:1095	arg1	properties					1063:1072	remarkable antioxidant properties	1040:1072	remarkable antioxidant properties	1040:1072	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	5	68	theme	homogeneous	720:730	arg1	FCPOS-1					750:756	FCPOS-1	750:756	FCPOS-1	750:756	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	5	68	theme	homogeneous	720:730	arg1	oligosaccharides					732:747	homogeneous oligosaccharides	720:747	homogeneous oligosaccharides (FCPOS-1)	720:757	The extracted POS was then fractionated and purified to homogeneous oligosaccharides (FCPOS-1) with a molecular weight of 2.15 kDa, and the analyses of monosaccharide composition, FTIR, NMR and ESI-MS indicated that FCPOS-1 consisted of GalA and a small amount of mannose, galactose and arabinose.
34664579	4	69	theme	50	617:618	arg1	mg					620:621	mg	620:621	mg	620:621	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	4	70	theme	0.25	590:593	arg1	mg					595:596	mg	595:596	mg	595:596	Using the orthogonal experiment design (OED), the maximum conversion rate of up to 64.5% from pomace to POS was obtained under the extraction conditions of 0.25 mg mL-1 pectinase and 50 mg mL-1 pectin at 45 °C and pH 4.5 for 2 h.
34664579	6	71	dep	in	999:1000	arg1	vitro					1002:1006	vitro	1002:1006	vitro	1002:1006	Multiple antioxidant activity assays in vitro revealed that FCPOS-1 possessed remarkable antioxidant properties, especially scavenging activity against DPPH radicals up to 94.07%.
34664579	7	72	from	applications	1211:1222	arg1	industries					1255:1264	the food and pharmaceutical industries	1227:1264	the food and pharmaceutical industries	1227:1264	FCPOS-1 has the potential to be an effective natural antioxidant for applications in the food and pharmaceutical industries.
34664579	2	73	dep	60	259:260	arg1	to					256:257	to	256:257	to	256:257	Finger citron pomace is a cheap and renewable by-product of the citrus processing industry, representing up to 60% of the fruit biomass.
32112835	2	0	dep	produce	441:447	arg1	acetylated					449:458	acetylated	449:458	acetylated	449:458	In this study, starch was isolated from African breadfruit kernels and modified to produce acetylated, AC, oxidized, OX, and acid-thinned, AT, starches.
32112835	5	1	theme	direct	813:818	arg1	relationship					820:831	direct relationship	813:831	direct relationship	813:831	Swelling power had direct relationship with increase in temperature.
32112835	0	2	theme	kernel	62:67	arg1	starch					69:74	Modification of African breadfruit (Treculia africana, Decne) kernel starch	0:74	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.	0:140	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.
32112835	1	3	theme	starch	322:327	arg1	modifications					329:341	starch modifications	322:341	starch modifications	322:341	The need for starch to meet the ever-increasing industrial applications and its inherent problems in the native state have led to researches into unconventional starch sources and starch modifications, respectively.
32112835	4	4	theme	fibre	774:778	arg1	compositions					780:791	crude fibre compositions	768:791	crude fibre compositions	768:791	Modifications caused significant (p < .05) reductions in the NA starch moisture, ash, crude protein, crude fat, and crude fibre compositions.
32112835	6	5	theme	modified	1017:1024	arg1	starches					1026:1033	the modified starches	1013:1033	the modified starches	1013:1033	Following modifications, OX starch showed the most significant increase in oil absorption capacity while NA had better water absorption capacity than the modified starches.
32112835	10	6	theme	transition	1496:1505	arg1	temperature					1507:1517	gelatinisation transition temperature	1481:1517	gelatinisation transition temperature of NA	1481:1523	DSC study showed that gelatinisation transition temperature of NA reduced following modification.
32112835	8	7	with	oblong	1200:1205	arg1	surfaces					1236:1243	rough surfaces	1230:1243	rough surfaces for all the starches with no significant differences	1230:1296	Morphological study using scanning electron micrograph, revealed oblong and oval granules with rough surfaces for all the starches with no significant differences.
32112835	0	8	theme	Physicochemical	77:91	arg1	properties					130:139	Physicochemical, morphological, pasting, and thermal properties	77:139	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.	0:140	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.
32112835	3	9	theme	thermal	632:638	arg1	properties					640:649	physicochemical, pasting, morphological and thermal properties	588:649	physicochemical, pasting, morphological and thermal properties	588:649	The effects of modifications on the native starch, NA, were examined through physicochemical, pasting, morphological and thermal properties.
32112835	4	10	theme	crude	753:757	arg1	fat					759:761	crude fat	753:761	crude fat	753:761	Modifications caused significant (p < .05) reductions in the NA starch moisture, ash, crude protein, crude fat, and crude fibre compositions.
32112835	6	11	theme	significant	914:924	arg1	increase					926:933	the most significant increase	905:933	the most significant increase in oil absorption capacity	905:960	Following modifications, OX starch showed the most significant increase in oil absorption capacity while NA had better water absorption capacity than the modified starches.
32112835	1	12	theme	native	247:252	arg1	state					254:258	the native state	243:258	the native state	243:258	The need for starch to meet the ever-increasing industrial applications and its inherent problems in the native state have led to researches into unconventional starch sources and starch modifications, respectively.
32112835	0	13	theme	morphological	94:106	arg1	properties					130:139	Physicochemical, morphological, pasting, and thermal properties	77:139	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.	0:140	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.
32112835	6	14	contain	had	971:973	arg1	NA					968:969	NA	968:969	NA	968:969	Following modifications, OX starch showed the most significant increase in oil absorption capacity while NA had better water absorption capacity than the modified starches.
32112835	6	14	contain	had	971:973	arg2	capacity					999:1006	better water absorption capacity	975:1006	better water absorption capacity	975:1006	Following modifications, OX starch showed the most significant increase in oil absorption capacity while NA had better water absorption capacity than the modified starches.
32112835	4	15	theme	starch	716:721	arg1	moisture					723:730	the NA starch moisture	709:730	the NA starch moisture	709:730	Modifications caused significant (p < .05) reductions in the NA starch moisture, ash, crude protein, crude fat, and crude fibre compositions.
32112835	9	16	theme	modifications	1444:1456	arg1	stability					1388:1396	increased thermal stability	1370:1396	increased thermal stability of African breadfruit kernel starch following modifications	1370:1456	Thermogravimetry of the starches showed single-step decomposition with increased thermal stability of African breadfruit kernel starch following modifications.
32112835	9	17	theme	starch	1427:1432	arg1	modifications					1444:1456	African breadfruit kernel starch following modifications	1401:1456	African breadfruit kernel starch following modifications	1401:1456	Thermogravimetry of the starches showed single-step decomposition with increased thermal stability of African breadfruit kernel starch following modifications.
32112835	9	18	theme	kernel	1420:1425	arg1	modifications					1444:1456	African breadfruit kernel starch following modifications	1401:1456	African breadfruit kernel starch following modifications	1401:1456	Thermogravimetry of the starches showed single-step decomposition with increased thermal stability of African breadfruit kernel starch following modifications.
32112835	4	19	theme	NA	713:714	arg1	moisture					723:730	the NA starch moisture	709:730	the NA starch moisture	709:730	Modifications caused significant (p < .05) reductions in the NA starch moisture, ash, crude protein, crude fat, and crude fibre compositions.
32112835	9	20	theme	following	1434:1442	arg1	modifications					1444:1456	African breadfruit kernel starch following modifications	1401:1456	African breadfruit kernel starch following modifications	1401:1456	Thermogravimetry of the starches showed single-step decomposition with increased thermal stability of African breadfruit kernel starch following modifications.
32112835	7	21	theme	NA	1124:1125	arg1	starch					1127:1132	NA starch	1124:1132	NA starch	1124:1132	Acid-thinning significantly improved the gelation and reduced the pasting properties of NA starch.
32112835	8	22	with	granules	1216:1223	arg1	surfaces					1236:1243	rough surfaces	1230:1243	rough surfaces for all the starches with no significant differences	1230:1296	Morphological study using scanning electron micrograph, revealed oblong and oval granules with rough surfaces for all the starches with no significant differences.
32112835	4	23	theme	crude	768:772	arg1	compositions					780:791	crude fibre compositions	768:791	crude fibre compositions	768:791	Modifications caused significant (p < .05) reductions in the NA starch moisture, ash, crude protein, crude fat, and crude fibre compositions.
32112835	11	24	theme	African	1601:1607	arg1	properties					1634:1643	African breadfruit kernel starch properties	1601:1643	African breadfruit kernel starch properties	1601:1643	The study showed that modification improved African breadfruit kernel starch properties.
32112835	0	25	dep	starch	69:74	arg1	properties					130:139	Physicochemical, morphological, pasting, and thermal properties	77:139	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.	0:140	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.
32112835	11	26	theme	kernel	1620:1625	arg1	properties					1634:1643	African breadfruit kernel starch properties	1601:1643	African breadfruit kernel starch properties	1601:1643	The study showed that modification improved African breadfruit kernel starch properties.
32112835	8	27	theme	oval	1211:1214	arg1	granules					1216:1223	oval granules	1211:1223	oval granules with rough surfaces for all the starches with no significant differences	1211:1296	Morphological study using scanning electron micrograph, revealed oblong and oval granules with rough surfaces for all the starches with no significant differences.
32112835	0	28	theme	Modification	0:11	arg1	starch					69:74	Modification of African breadfruit (Treculia africana, Decne) kernel starch	0:74	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.	0:140	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.
32112835	6	29	from	increase	926:933	arg1	capacity					953:960	oil absorption capacity	938:960	oil absorption capacity	938:960	Following modifications, OX starch showed the most significant increase in oil absorption capacity while NA had better water absorption capacity than the modified starches.
32112835	9	30	theme	single-step	1339:1349	arg1	decomposition					1351:1363	single-step decomposition	1339:1363	single-step decomposition	1339:1363	Thermogravimetry of the starches showed single-step decomposition with increased thermal stability of African breadfruit kernel starch following modifications.
32112835	5	31	theme	Swelling	794:801	arg1	power					803:807	Swelling power	794:807	Swelling power	794:807	Swelling power had direct relationship with increase in temperature.
32112835	0	32	theme	breadfruit	24:33	arg1	Modification					0:11	Modification	0:11	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.	0:140	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.
32112835	0	32	theme	breadfruit	24:33	arg1	Decne					55:59	Decne	55:59	Decne	55:59	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.
32112835	0	33	theme	pasting	109:115	arg1	properties					130:139	Physicochemical, morphological, pasting, and thermal properties	77:139	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.	0:140	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.
32112835	5	34	from	increase	838:845	arg1	temperature					850:860	temperature	850:860	temperature	850:860	Swelling power had direct relationship with increase in temperature.
32112835	6	35	theme	oil	938:940	arg1	capacity					953:960	oil absorption capacity	938:960	oil absorption capacity	938:960	Following modifications, OX starch showed the most significant increase in oil absorption capacity while NA had better water absorption capacity than the modified starches.
32112835	10	36	theme	DSC	1459:1461	arg1	study					1463:1467	DSC study	1459:1467	DSC study	1459:1467	DSC study showed that gelatinisation transition temperature of NA reduced following modification.
32112835	2	37	theme	African	398:404	arg1	kernels					417:423	African breadfruit kernels	398:423	African breadfruit kernels	398:423	In this study, starch was isolated from African breadfruit kernels and modified to produce acetylated, AC, oxidized, OX, and acid-thinned, AT, starches.
32112835	2	38	theme	breadfruit	406:415	arg1	kernels					417:423	African breadfruit kernels	398:423	African breadfruit kernels	398:423	In this study, starch was isolated from African breadfruit kernels and modified to produce acetylated, AC, oxidized, OX, and acid-thinned, AT, starches.
32112835	8	39	with	starches	1257:1264	arg1	differences					1286:1296	no significant differences	1271:1296	no significant differences	1271:1296	Morphological study using scanning electron micrograph, revealed oblong and oval granules with rough surfaces for all the starches with no significant differences.
32112835	8	40	theme	significant	1274:1284	arg1	differences					1286:1296	no significant differences	1271:1296	no significant differences	1271:1296	Morphological study using scanning electron micrograph, revealed oblong and oval granules with rough surfaces for all the starches with no significant differences.
32112835	6	41	theme	better	975:980	arg1	absorption					988:997	better water absorption	975:997	better water absorption capacity	975:1006	Following modifications, OX starch showed the most significant increase in oil absorption capacity while NA had better water absorption capacity than the modified starches.
32112835	8	42	theme	electron	1170:1177	arg1	micrograph					1179:1188	scanning electron micrograph	1161:1188	scanning electron micrograph	1161:1188	Morphological study using scanning electron micrograph, revealed oblong and oval granules with rough surfaces for all the starches with no significant differences.
32112835	6	43	theme	OX	888:889	arg1	starch					891:896	OX starch	888:896	OX starch	888:896	Following modifications, OX starch showed the most significant increase in oil absorption capacity while NA had better water absorption capacity than the modified starches.
32112835	1	44	from	problems	231:238	arg1	state					254:258	the native state	243:258	the native state	243:258	The need for starch to meet the ever-increasing industrial applications and its inherent problems in the native state have led to researches into unconventional starch sources and starch modifications, respectively.
32112835	3	45	theme	physicochemical	588:602	arg1	properties					640:649	physicochemical, pasting, morphological and thermal properties	588:649	physicochemical, pasting, morphological and thermal properties	588:649	The effects of modifications on the native starch, NA, were examined through physicochemical, pasting, morphological and thermal properties.
32112835	6	46	theme	absorption	988:997	arg1	capacity					999:1006	better water absorption capacity	975:1006	better water absorption capacity	975:1006	Following modifications, OX starch showed the most significant increase in oil absorption capacity while NA had better water absorption capacity than the modified starches.
32112835	1	47	theme	ever-increasing	174:188	arg1	applications					201:212	the ever-increasing industrial applications	170:212	the ever-increasing industrial applications	170:212	The need for starch to meet the ever-increasing industrial applications and its inherent problems in the native state have led to researches into unconventional starch sources and starch modifications, respectively.
32112835	7	48	theme	pasting	1102:1108	arg1	properties					1110:1119	the pasting properties	1098:1119	the pasting properties of NA starch	1098:1132	Acid-thinning significantly improved the gelation and reduced the pasting properties of NA starch.
32112835	9	49	theme	starches	1323:1330	arg1	Thermogravimetry					1299:1314	Thermogravimetry	1299:1314	Thermogravimetry of the starches	1299:1330	Thermogravimetry of the starches showed single-step decomposition with increased thermal stability of African breadfruit kernel starch following modifications.
32112835	8	50	theme	scanning	1161:1168	arg1	micrograph					1179:1188	scanning electron micrograph	1161:1188	scanning electron micrograph	1161:1188	Morphological study using scanning electron micrograph, revealed oblong and oval granules with rough surfaces for all the starches with no significant differences.
32112835	3	51	theme	native	547:552	arg1	NA					562:563	NA	562:563	NA	562:563	The effects of modifications on the native starch, NA, were examined through physicochemical, pasting, morphological and thermal properties.
32112835	3	51	theme	native	547:552	arg1	starch					554:559	the native starch	543:559	the native starch	543:559	The effects of modifications on the native starch, NA, were examined through physicochemical, pasting, morphological and thermal properties.
32112835	11	52	theme	starch	1627:1632	arg1	properties					1634:1643	African breadfruit kernel starch properties	1601:1643	African breadfruit kernel starch properties	1601:1643	The study showed that modification improved African breadfruit kernel starch properties.
32112835	1	53	theme	industrial	190:199	arg1	applications					201:212	the ever-increasing industrial applications	170:212	the ever-increasing industrial applications	170:212	The need for starch to meet the ever-increasing industrial applications and its inherent problems in the native state have led to researches into unconventional starch sources and starch modifications, respectively.
32112835	2	54	attach	isolated	384:391	arg2	starch					373:378	starch	373:378	starch	373:378	In this study, starch was isolated from African breadfruit kernels and modified to produce acetylated, AC, oxidized, OX, and acid-thinned, AT, starches.
32112835	2	54	attach	isolated	384:391	arg1	kernels					417:423	African breadfruit kernels	398:423	African breadfruit kernels	398:423	In this study, starch was isolated from African breadfruit kernels and modified to produce acetylated, AC, oxidized, OX, and acid-thinned, AT, starches.
32112835	3	55	theme	modifications	526:538	arg1	effects					515:521	The effects	511:521	The effects of modifications on the native starch, NA,	511:564	The effects of modifications on the native starch, NA, were examined through physicochemical, pasting, morphological and thermal properties.
32112835	10	56	theme	gelatinisation	1481:1494	arg1	temperature					1507:1517	gelatinisation transition temperature	1481:1517	gelatinisation transition temperature of NA	1481:1523	DSC study showed that gelatinisation transition temperature of NA reduced following modification.
32112835	1	57	theme	unconventional	288:301	arg1	sources					310:316	unconventional starch sources	288:316	unconventional starch sources	288:316	The need for starch to meet the ever-increasing industrial applications and its inherent problems in the native state have led to researches into unconventional starch sources and starch modifications, respectively.
32112835	0	58	theme	thermal	122:128	arg1	properties					130:139	Physicochemical, morphological, pasting, and thermal properties	77:139	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.	0:140	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.
32112835	11	59	theme	breadfruit	1609:1618	arg1	properties					1634:1643	African breadfruit kernel starch properties	1601:1643	African breadfruit kernel starch properties	1601:1643	The study showed that modification improved African breadfruit kernel starch properties.
32112835	1	60	theme	starch	303:308	arg1	sources					310:316	unconventional starch sources	288:316	unconventional starch sources	288:316	The need for starch to meet the ever-increasing industrial applications and its inherent problems in the native state have led to researches into unconventional starch sources and starch modifications, respectively.
32112835	3	61	theme	morphological	614:626	arg1	properties					640:649	physicochemical, pasting, morphological and thermal properties	588:649	physicochemical, pasting, morphological and thermal properties	588:649	The effects of modifications on the native starch, NA, were examined through physicochemical, pasting, morphological and thermal properties.
32112835	4	62	theme	crude	738:742	arg1	protein					744:750	crude protein	738:750	crude protein	738:750	Modifications caused significant (p < .05) reductions in the NA starch moisture, ash, crude protein, crude fat, and crude fibre compositions.
32112835	8	63	theme	rough	1230:1234	arg1	surfaces					1236:1243	rough surfaces	1230:1243	rough surfaces for all the starches with no significant differences	1230:1296	Morphological study using scanning electron micrograph, revealed oblong and oval granules with rough surfaces for all the starches with no significant differences.
32112835	10	64	theme	NA	1522:1523	arg1	temperature					1507:1517	gelatinisation transition temperature	1481:1517	gelatinisation transition temperature of NA	1481:1523	DSC study showed that gelatinisation transition temperature of NA reduced following modification.
32112835	9	65	theme	African	1401:1407	arg1	modifications					1444:1456	African breadfruit kernel starch following modifications	1401:1456	African breadfruit kernel starch following modifications	1401:1456	Thermogravimetry of the starches showed single-step decomposition with increased thermal stability of African breadfruit kernel starch following modifications.
32112835	9	66	theme	thermal	1380:1386	arg1	stability					1388:1396	increased thermal stability	1370:1396	increased thermal stability of African breadfruit kernel starch following modifications	1370:1456	Thermogravimetry of the starches showed single-step decomposition with increased thermal stability of African breadfruit kernel starch following modifications.
32112835	4	67	theme	significant	673:683	arg1	p <					686:688	p < .05	686:692	p < .05	686:692	Modifications caused significant (p < .05) reductions in the NA starch moisture, ash, crude protein, crude fat, and crude fibre compositions.
32112835	4	67	theme	significant	673:683	arg1	reductions					695:704	significant (p < .05) reductions	673:704	significant (p < .05) reductions	673:704	Modifications caused significant (p < .05) reductions in the NA starch moisture, ash, crude protein, crude fat, and crude fibre compositions.
32112835	3	68	from	effects	515:521	arg1	NA					562:563	NA	562:563	NA	562:563	The effects of modifications on the native starch, NA, were examined through physicochemical, pasting, morphological and thermal properties.
32112835	3	68	from	effects	515:521	arg1	starch					554:559	the native starch	543:559	the native starch	543:559	The effects of modifications on the native starch, NA, were examined through physicochemical, pasting, morphological and thermal properties.
32112835	9	69	theme	increased	1370:1378	arg1	stability					1388:1396	increased thermal stability	1370:1396	increased thermal stability of African breadfruit kernel starch following modifications	1370:1456	Thermogravimetry of the starches showed single-step decomposition with increased thermal stability of African breadfruit kernel starch following modifications.
32112835	3	70	theme	pasting	605:611	arg1	properties					640:649	physicochemical, pasting, morphological and thermal properties	588:649	physicochemical, pasting, morphological and thermal properties	588:649	The effects of modifications on the native starch, NA, were examined through physicochemical, pasting, morphological and thermal properties.
32112835	6	71	theme	water	982:986	arg1	absorption					988:997	better water absorption	975:997	better water absorption capacity	975:1006	Following modifications, OX starch showed the most significant increase in oil absorption capacity while NA had better water absorption capacity than the modified starches.
32112835	6	72	theme	absorption	942:951	arg1	capacity					953:960	oil absorption capacity	938:960	oil absorption capacity	938:960	Following modifications, OX starch showed the most significant increase in oil absorption capacity while NA had better water absorption capacity than the modified starches.
32112835	9	73	theme	breadfruit	1409:1418	arg1	modifications					1444:1456	African breadfruit kernel starch following modifications	1401:1456	African breadfruit kernel starch following modifications	1401:1456	Thermogravimetry of the starches showed single-step decomposition with increased thermal stability of African breadfruit kernel starch following modifications.
32112835	0	74	theme	African	16:22	arg1	breadfruit					24:33	African breadfruit	16:33	African breadfruit	16:33	Modification of African breadfruit (Treculia africana, Decne) kernel starch: Physicochemical, morphological, pasting, and thermal properties.
32112835	5	75	contain	had	809:811	arg1	power					803:807	Swelling power	794:807	Swelling power	794:807	Swelling power had direct relationship with increase in temperature.
32112835	5	75	contain	had	809:811	arg2	relationship					820:831	direct relationship	813:831	direct relationship	813:831	Swelling power had direct relationship with increase in temperature.
32112835	8	76	theme	Morphological	1135:1147	arg1	study					1149:1153	Morphological study	1135:1153	Morphological study	1135:1153	Morphological study using scanning electron micrograph, revealed oblong and oval granules with rough surfaces for all the starches with no significant differences.
32112835	7	77	theme	starch	1127:1132	arg1	properties					1110:1119	the pasting properties	1098:1119	the pasting properties of NA starch	1098:1132	Acid-thinning significantly improved the gelation and reduced the pasting properties of NA starch.
32112835	1	78	theme	inherent	222:229	arg1	problems					231:238	its inherent problems	218:238	its inherent problems in the native state	218:258	The need for starch to meet the ever-increasing industrial applications and its inherent problems in the native state have led to researches into unconventional starch sources and starch modifications, respectively.
33374385	0	0	theme	Nopal	69:73	arg1	indica					96:101	Opuntia ficus indica	82:101	Opuntia ficus indica	82:101	Development of a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica).
33374385	0	0	theme	Nopal	69:73	arg1	Flour					75:79	Nopal Flour	69:79	Nopal Flour (Opuntia ficus indica)	69:102	Development of a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica).
33374385	5	1	theme	-6.51	1098:1102	arg1	0.004					1106:1110	-6.51 ± 0.004	1098:1110	-6.51 ± 0.004	1098:1110	According to the color analysis the NF obtained a value of 60.73 ± 0.008 in L* and -6.51 ± 0.004 in a* with green tendency.
33374385	3	2	theme	L	739:739	arg1	luminosity					727:736	luminosity	727:736	luminosity (L*)	727:741	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	3	2	theme	L	739:739	arg1	*					740:740	L*	739:740	L*	739:740	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	2	3	theme	absorption	365:374	arg1	WSI					416:418	WSI	416:418	WSI	416:418	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	3	theme	absorption	365:374	arg1	WAI					383:385	WAI	383:385	WAI	383:385	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	3	theme	absorption	365:374	arg1	index					376:380	water absorption index	359:380	water absorption index (WAI)	359:386	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	3	theme	absorption	365:374	arg1	analysis					317:324	proximal analysis	308:324	proximal analysis	308:324	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	1	4	theme	xanthan	248:254	arg1	XG					261:262	XG	261:262	XG	261:262	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33374385	1	4	theme	xanthan	248:254	arg1	gum					256:258	xanthan gum	248:258	xanthan gum (XG)	248:263	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33374385	3	5	from	analysis	594:601	arg1	formulations					641:652	the nine formulations	632:652	the nine formulations of the snack	632:665	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	6	6	theme	food	1224:1227	arg1	use					1229:1231	food use	1224:1231	food use	1224:1231	The DS value obtained was 0.09 ± 0.005, being within the FDA's permissible range for food use.
33374385	8	7	theme	highest	1401:1407	arg1	value					1412:1416	the highest EI value	1397:1416	the highest EI value	1397:1416	Finally, employing microwave cooking, snacks made from NS with concentrations of NF (5%) and XG (0%) obtained the highest EI value, 4.47, as well the low Dap and D value (0.37 g/cm3, 2.25 N, respectively), corroborated by SEM analysis.
33374385	2	8	theme	solubility	398:407	arg1	index					409:413	water solubility index	392:413	water solubility index	392:413	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	8	theme	solubility	398:407	arg1	analysis					317:324	proximal analysis	308:324	proximal analysis	308:324	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	5	9	theme	60.73	1074:1078	arg1	±					1080:1080	60.73 ± 0.008	1074:1086	60.73 ± 0.008	1074:1086	According to the color analysis the NF obtained a value of 60.73 ± 0.008 in L* and -6.51 ± 0.004 in a* with green tendency.
33374385	5	10	dep	obtained	1054:1061	arg1	According					1015:1023	According	1015:1023	According to the color analysis	1015:1045	According to the color analysis the NF obtained a value of 60.73 ± 0.008 in L* and -6.51 ± 0.004 in a* with green tendency.
33374385	2	11	theme	water	392:396	arg1	index					409:413	water solubility index	392:413	water solubility index	392:413	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	11	theme	water	392:396	arg1	analysis					317:324	proximal analysis	308:324	proximal analysis	308:324	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	8	12	theme	EI	1409:1410	arg1	value					1412:1416	the highest EI value	1397:1416	the highest EI value	1397:1416	Finally, employing microwave cooking, snacks made from NS with concentrations of NF (5%) and XG (0%) obtained the highest EI value, 4.47, as well the low Dap and D value (0.37 g/cm3, 2.25 N, respectively), corroborated by SEM analysis.
33374385	5	13	theme	±	1080:1080	arg1	value					1065:1069	a value	1063:1069	a value of 60.73 ± 0.008	1063:1086	According to the color analysis the NF obtained a value of 60.73 ± 0.008 in L* and -6.51 ± 0.004 in a* with green tendency.
33374385	6	14	theme	DS	1143:1144	arg1	value					1146:1150	The DS value	1139:1150	The DS value obtained	1139:1159	The DS value obtained was 0.09 ± 0.005, being within the FDA's permissible range for food use.
33374385	6	14	theme	DS	1143:1144	arg1	0.09					1165:1168	0.09	1165:1168	0.09	1165:1168	The DS value obtained was 0.09 ± 0.005, being within the FDA's permissible range for food use.
33374385	0	15	theme	ficus	90:94	arg1	indica					96:101	Opuntia ficus indica	82:101	Opuntia ficus indica	82:101	Development of a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica).
33374385	0	15	theme	ficus	90:94	arg1	Flour					75:79	Nopal Flour	69:79	Nopal Flour (Opuntia ficus indica)	69:102	Development of a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica).
33374385	3	16	theme	central	809:815	arg1	CCD					825:827	CCD	825:827	CCD	825:827	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	3	16	theme	central	809:815	arg1	design					817:822	a composite central design	797:822	a composite central design (CCD)	797:828	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	2	17	theme	proximal	308:315	arg1	pH					327:328	pH	327:328	pH	327:328	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	17	theme	proximal	308:315	arg1	Fourier					502:508	Fourier	502:508	Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM)	502:587	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	17	theme	proximal	308:315	arg1	degree					422:427	degree	422:427	degree of substitution (DS)	422:448	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	17	theme	proximal	308:315	arg1	rheology					492:499	rheology	492:499	rheology	492:499	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	17	theme	proximal	308:315	arg1	index					376:380	water absorption index	359:380	water absorption index (WAI)	359:386	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	17	theme	proximal	308:315	arg1	index					409:413	water solubility index	392:413	water solubility index	392:413	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	17	theme	proximal	308:315	arg1	calorimetry					473:483	differential scanning calorimetry	451:483	differential scanning calorimetry (DSC)	451:489	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	17	theme	proximal	308:315	arg1	analysis					317:324	proximal analysis	308:324	proximal analysis	308:324	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	17	theme	proximal	308:315	arg1	distribution					345:356	particle size distribution	331:356	particle size distribution	331:356	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	7	18	theme	acetyl	1256:1261	arg1	group					1263:1267	the acetyl group	1252:1267	the acetyl group	1252:1267	By FTIR analysis, the acetyl group was corroborated.
33374385	0	19	theme	Opuntia	82:88	arg1	indica					96:101	Opuntia ficus indica	82:101	Opuntia ficus indica	82:101	Development of a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica).
33374385	0	19	theme	Opuntia	82:88	arg1	Flour					75:79	Nopal Flour	69:79	Nopal Flour (Opuntia ficus indica)	69:102	Development of a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica).
33374385	4	20	theme	NS	975:976	arg1	values					978:983	NS values	975:983	NS values due to chemical modification	975:1012	Results showed an increase in WAI, 4.69 ± 0.04, and WSI, 12.61 ± 0.10, for MS, higher than NS values due to chemical modification.
33374385	2	21	theme	water	359:363	arg1	WSI					416:418	WSI	416:418	WSI	416:418	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	21	theme	water	359:363	arg1	WAI					383:385	WAI	383:385	WAI	383:385	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	21	theme	water	359:363	arg1	index					376:380	water absorption index	359:380	water absorption index (WAI)	359:386	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	21	theme	water	359:363	arg1	analysis					317:324	proximal analysis	308:324	proximal analysis	308:324	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	22	theme	infrared	520:527	arg1	FT-IR					543:547	FT-IR	543:547	FT-IR	543:547	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	22	theme	infrared	520:527	arg1	spectroscopy					529:540	infrared spectroscopy	520:540	infrared spectroscopy (FT-IR)	520:548	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	3	23	theme	apparent	690:697	arg1	AD					708:709	AD	708:709	AD	708:709	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	3	23	theme	apparent	690:697	arg1	density					699:705	apparent density	690:705	apparent density (AD)	690:710	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	3	23	theme	apparent	690:697	arg1	variables					619:627	the response variables	606:627	the response variables in the nine formulations of the snack	606:665	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	1	24	theme	third-generation	134:149	arg1	snack					151:155	a third-generation snack	132:155	a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG)	132:263	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33374385	2	25	theme	particle	331:338	arg1	distribution					345:356	particle size distribution	331:356	particle size distribution	331:356	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	25	theme	particle	331:338	arg1	analysis					317:324	proximal analysis	308:324	proximal analysis	308:324	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	8	26	theme	D	1449:1449	arg1	value					1451:1455	the low Dap and D value	1433:1455	value	1451:1455	Finally, employing microwave cooking, snacks made from NS with concentrations of NF (5%) and XG (0%) obtained the highest EI value, 4.47, as well the low Dap and D value (0.37 g/cm3, 2.25 N, respectively), corroborated by SEM analysis.
33374385	2	27	theme	scanning	464:471	arg1	DSC					486:488	DSC	486:488	DSC	486:488	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	27	theme	scanning	464:471	arg1	calorimetry					473:483	differential scanning calorimetry	451:483	differential scanning calorimetry (DSC)	451:489	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	27	theme	scanning	464:471	arg1	analysis					317:324	proximal analysis	308:324	proximal analysis	308:324	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	8	28	theme	4.47	1419:1422	arg1	value					1412:1416	the highest EI value	1397:1416	the highest EI value	1397:1416	Finally, employing microwave cooking, snacks made from NS with concentrations of NF (5%) and XG (0%) obtained the highest EI value, 4.47, as well the low Dap and D value (0.37 g/cm3, 2.25 N, respectively), corroborated by SEM analysis.
33374385	2	29	theme	raw	272:274	arg1	materials					276:284	These raw materials	266:284	These raw materials	266:284	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	4	30	theme	chemical	992:999	arg1	modification					1001:1012	chemical modification	992:1012	chemical modification	992:1012	Results showed an increase in WAI, 4.69 ± 0.04, and WSI, 12.61 ± 0.10, for MS, higher than NS values due to chemical modification.
33374385	2	31	theme	differential	451:462	arg1	DSC					486:488	DSC	486:488	DSC	486:488	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	31	theme	differential	451:462	arg1	calorimetry					473:483	differential scanning calorimetry	451:483	differential scanning calorimetry (DSC)	451:489	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	31	theme	differential	451:462	arg1	analysis					317:324	proximal analysis	308:324	proximal analysis	308:324	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	8	32	theme	XG	1380:1381	arg1	concentrations					1350:1363	concentrations	1350:1363	concentrations of NF (5%) and XG (0%)	1350:1386	Finally, employing microwave cooking, snacks made from NS with concentrations of NF (5%) and XG (0%) obtained the highest EI value, 4.47, as well the low Dap and D value (0.37 g/cm3, 2.25 N, respectively), corroborated by SEM analysis.
33374385	8	33	theme	NF	1368:1369	arg1	concentrations					1350:1363	concentrations	1350:1363	concentrations of NF (5%) and XG (0%)	1350:1386	Finally, employing microwave cooking, snacks made from NS with concentrations of NF (5%) and XG (0%) obtained the highest EI value, 4.47, as well the low Dap and D value (0.37 g/cm3, 2.25 N, respectively), corroborated by SEM analysis.
33374385	5	34	theme	±	1104:1104	arg1	0.004					1106:1110	-6.51 ± 0.004	1098:1110	-6.51 ± 0.004	1098:1110	According to the color analysis the NF obtained a value of 60.73 ± 0.008 in L* and -6.51 ± 0.004 in a* with green tendency.
33374385	0	35	theme	Third	17:21	arg1	Snack					34:38	a Third Generation Snack	15:38	a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica)	15:102	Development of a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica).
33374385	3	36	theme	a	770:770	arg1	green-red					759:767	green-red	759:767	green-red	759:767	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	3	36	theme	a	770:770	arg1	*					771:771	a*	770:771	a*	770:771	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	7	37	theme	FTIR	1237:1240	arg1	analysis					1242:1249	FTIR analysis	1237:1249	FTIR analysis	1237:1249	By FTIR analysis, the acetyl group was corroborated.
33374385	1	38	theme	native	162:167	arg1	NS					182:183	NS	182:183	NS	182:183	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33374385	1	38	theme	native	162:167	arg1	starch					174:179	native rice starch	162:179	native rice starch (NS)	162:184	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33374385	1	38	theme	native	162:167	arg1	starch					192:197	rice starch	187:197	rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG)	187:263	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33374385	3	39	from	formulations	641:652	arg1	analysis					594:601	The analysis	590:601	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*),	590:773	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	8	40	theme	microwave	1306:1314	arg1	cooking					1316:1322	microwave cooking	1306:1322	microwave cooking	1306:1322	Finally, employing microwave cooking, snacks made from NS with concentrations of NF (5%) and XG (0%) obtained the highest EI value, 4.47, as well the low Dap and D value (0.37 g/cm3, 2.25 N, respectively), corroborated by SEM analysis.
33374385	1	41	theme	rice	169:172	arg1	NS					182:183	NS	182:183	NS	182:183	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33374385	1	41	theme	rice	169:172	arg1	starch					174:179	native rice starch	162:179	native rice starch (NS)	162:184	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33374385	1	41	theme	rice	169:172	arg1	starch					192:197	rice starch	187:197	rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG)	187:263	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33374385	0	42	theme	Snack	34:38	arg1	Development					0:10	Development	0:10	Development of a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica).	0:103	Development of a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica).
33374385	3	43	dep	variables	619:627	arg1	EI					685:686	EI	685:686	EI	685:686	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	3	43	dep	variables	619:627	arg1	index					678:682	expansion index	668:682	expansion index (EI)	668:687	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	4	44	from	increase	902:909	arg1	WSI					936:938	WSI	936:938	WSI	936:938	Results showed an increase in WAI, 4.69 ± 0.04, and WSI, 12.61 ± 0.10, for MS, higher than NS values due to chemical modification.
33374385	4	44	from	increase	902:909	arg1	±					947:947	12.61 ± 0.10	941:952	12.61 ± 0.10	941:952	Results showed an increase in WAI, 4.69 ± 0.04, and WSI, 12.61 ± 0.10, for MS, higher than NS values due to chemical modification.
33374385	4	44	from	increase	902:909	arg1	WAI					914:916	WAI	914:916	WAI	914:916	Results showed an increase in WAI, 4.69 ± 0.04, and WSI, 12.61 ± 0.10, for MS, higher than NS values due to chemical modification.
33374385	4	44	from	increase	902:909	arg1	±					924:924	4.69 ± 0.04	919:929	4.69 ± 0.04	919:929	Results showed an increase in WAI, 4.69 ± 0.04, and WSI, 12.61 ± 0.10, for MS, higher than NS values due to chemical modification.
33374385	5	45	with	*	1116:1116	arg1	tendency					1129:1136	green tendency	1123:1136	green tendency	1123:1136	According to the color analysis the NF obtained a value of 60.73 ± 0.008 in L* and -6.51 ± 0.004 in a* with green tendency.
33374385	0	46	theme	Generation	23:32	arg1	Snack					34:38	a Third Generation Snack	15:38	a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica)	15:102	Development of a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica).
33374385	1	47	theme	nopal	227:231	arg1	flour					233:237	nopal flour	227:237	nopal flour (NF)	227:242	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33374385	1	47	theme	nopal	227:231	arg1	NF					240:241	NF	240:241	NF	240:241	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33374385	5	48	theme	green	1123:1127	arg1	tendency					1129:1136	green tendency	1123:1136	green tendency	1123:1136	According to the color analysis the NF obtained a value of 60.73 ± 0.008 in L* and -6.51 ± 0.004 in a* with green tendency.
33374385	1	49	from	starch	174:179	arg1	snack					151:155	a third-generation snack	132:155	a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG)	132:263	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33374385	0	50	theme	Rice	43:46	arg1	Starch					48:53	Rice Starch	43:53	Rice Starch Enriched with Nopal Flour (Opuntia ficus indica)	43:102	Development of a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica).
33374385	3	51	theme	composite	799:807	arg1	CCD					825:827	CCD	825:827	CCD	825:827	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	3	51	theme	composite	799:807	arg1	design					817:822	a composite central design	797:822	a composite central design (CCD)	797:828	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	2	52	theme	substitution	432:443	arg1	degree					422:427	degree	422:427	degree of substitution (DS)	422:448	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	52	theme	substitution	432:443	arg1	analysis					317:324	proximal analysis	308:324	proximal analysis	308:324	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	6	53	theme	permissible	1202:1212	arg1	range					1214:1218	the FDA's permissible range	1192:1218	the FDA's permissible range for food use	1192:1231	The DS value obtained was 0.09 ± 0.005, being within the FDA's permissible range for food use.
33374385	5	54	theme	color	1032:1036	arg1	analysis					1038:1045	the color analysis	1028:1045	the color analysis	1028:1045	According to the color analysis the NF obtained a value of 60.73 ± 0.008 in L* and -6.51 ± 0.004 in a* with green tendency.
33374385	2	55	theme	size	340:343	arg1	distribution					345:356	particle size distribution	331:356	particle size distribution	331:356	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	55	theme	size	340:343	arg1	analysis					317:324	proximal analysis	308:324	proximal analysis	308:324	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	3	56	from	variables	619:627	arg1	formulations					641:652	the nine formulations	632:652	the nine formulations of the snack	632:665	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	5	57	theme	L	1091:1091	arg1	*					1092:1092	L*	1091:1092	L*	1091:1092	According to the color analysis the NF obtained a value of 60.73 ± 0.008 in L* and -6.51 ± 0.004 in a* with green tendency.
33374385	2	58	dep	Fourier	502:508	arg1	transform					510:518	transform	510:518	transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM)	510:587	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	8	59	theme	low	1437:1439	arg1	Dap					1441:1443	the low Dap and D value	1433:1455	Dap	1441:1443	Finally, employing microwave cooking, snacks made from NS with concentrations of NF (5%) and XG (0%) obtained the highest EI value, 4.47, as well the low Dap and D value (0.37 g/cm3, 2.25 N, respectively), corroborated by SEM analysis.
33374385	3	60	theme	expansion	668:676	arg1	EI					685:686	EI	685:686	EI	685:686	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	3	60	theme	expansion	668:676	arg1	index					678:682	expansion index	668:682	expansion index (EI)	668:687	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	8	61	dep	Dap	1441:1443	arg1	g/cm3					1463:1467	0.37 g/cm3	1458:1467	0.37 g/cm3	1458:1467	Finally, employing microwave cooking, snacks made from NS with concentrations of NF (5%) and XG (0%) obtained the highest EI value, 4.47, as well the low Dap and D value (0.37 g/cm3, 2.25 N, respectively), corroborated by SEM analysis.
33374385	8	61	dep	Dap	1441:1443	arg1	N					1475:1475	2.25 N	1470:1475	2.25 N	1470:1475	Finally, employing microwave cooking, snacks made from NS with concentrations of NF (5%) and XG (0%) obtained the highest EI value, 4.47, as well the low Dap and D value (0.37 g/cm3, 2.25 N, respectively), corroborated by SEM analysis.
33374385	3	62	theme	selected	835:842	arg1	formulations					844:855	the selected formulations	831:855	the selected formulations	831:855	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	3	63	theme	snack	661:665	arg1	formulations					641:652	the nine formulations	632:652	the nine formulations of the snack	632:665	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	2	64	theme	electron	563:570	arg1	SEM					584:586	SEM	584:586	SEM	584:586	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	64	theme	electron	563:570	arg1	microscopy					572:581	scanning electron microscopy	554:581	scanning electron microscopy (SEM)	554:587	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	8	65	theme	SEM	1509:1511	arg1	analysis					1513:1520	SEM analysis	1509:1520	SEM analysis	1509:1520	Finally, employing microwave cooking, snacks made from NS with concentrations of NF (5%) and XG (0%) obtained the highest EI value, 4.47, as well the low Dap and D value (0.37 g/cm3, 2.25 N, respectively), corroborated by SEM analysis.
33374385	3	66	theme	response	610:617	arg1	tendency					747:754	tendency	747:754	tendency	747:754	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	3	66	theme	response	610:617	arg1	luminosity					727:736	luminosity	727:736	luminosity (L*)	727:741	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	3	66	theme	response	610:617	arg1	hardness					713:720	hardness	713:720	hardness (H)	713:724	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	3	66	theme	response	610:617	arg1	variables					619:627	the response variables	606:627	the response variables in the nine formulations of the snack	606:665	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	3	66	theme	response	610:617	arg1	density					699:705	apparent density	690:705	apparent density (AD)	690:710	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	0	67	theme	Starch	48:53	arg1	Snack					34:38	a Third Generation Snack	15:38	a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica)	15:102	Development of a Third Generation Snack of Rice Starch Enriched with Nopal Flour (Opuntia ficus indica).
33374385	4	68	theme	due	985:987	arg1	values					978:983	NS values	975:983	NS values due to chemical modification	975:1012	Results showed an increase in WAI, 4.69 ± 0.04, and WSI, 12.61 ± 0.10, for MS, higher than NS values due to chemical modification.
33374385	3	69	theme	variables	619:627	arg1	analysis					594:601	The analysis	590:601	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*),	590:773	The analysis of the response variables in the nine formulations of the snack: expansion index (EI), apparent density (AD), hardness (H), luminosity (L*) and tendency to green-red (a*), was performed through a composite central design (CCD), the selected formulations were characterized by SEM.
33374385	2	70	theme	scanning	554:561	arg1	SEM					584:586	SEM	584:586	SEM	584:586	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	2	70	theme	scanning	554:561	arg1	microscopy					572:581	scanning electron microscopy	554:581	scanning electron microscopy (SEM)	554:587	These raw materials were characterized by proximal analysis, pH, particle size distribution, water absorption index (WAI) and water solubility index (WSI), degree of substitution (DS), differential scanning calorimetry (DSC), rheology, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM).
33374385	1	71	theme	rice	187:190	arg1	starch					174:179	native rice starch	162:179	native rice starch (NS)	162:184	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33374385	1	71	theme	rice	187:190	arg1	starch					192:197	rice starch	187:197	rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG)	187:263	This study aimed to obtain a third-generation snack from native rice starch (NS), rice starch modified by extrusion (MS), nopal flour (NF) and xanthan gum (XG).
33158502	6	0	theme	active	1253:1258	arg1	sites					1260:1264	more accessible active sites	1237:1264	more accessible active sites	1237:1264	Moreover, the activity of this composite greatly surpassed that of bare MnO2 for nearly 50%, owing to its larger surface area and more accessible active sites.
33158502	1	1	theme	dip	307:309	arg1	catalyst					311:318	an efficient and retrievable dip catalyst	278:318	an efficient and retrievable dip catalyst MnO2/CH-FP	278:329	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	5	2	theme	degradation	1060:1070	arg1	efficiency					1072:1081	83.3% degradation efficiency	1054:1081	83.3% degradation efficiency of MB after six cycles	1054:1104	It is also shown that 1.0MnO2/CH-FP could still keep 83.3% degradation efficiency of MB after six cycles.
33158502	4	3	theme	30 mg L-1	978:986	arg1	MB					956:957	50 mg L-1 MB	946:957	50 mg L-1 MB	946:957	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	4	3	theme	30 mg L-1	978:986	arg1	H2O2					988:991	30 mg L-1 H2O2	978:991	30 mg L-1 H2O2	978:991	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	2	4	theme	MnO2	425:428	arg1	nanoparticles					430:442	The MnO2 nanoparticles	421:442	The MnO2 nanoparticles	421:442	The MnO2 nanoparticles were uniformly immobilized in the CH-FP matrix by in-situ redox precipitation method where Mn(NO3)2 was treated with KMnO4 at mild conditions.
33158502	1	5	theme	catalyst	311:318	arg1	MnO2/CH-FP					320:329	an efficient and retrievable dip catalyst MnO2/CH-FP	278:329	an efficient and retrievable dip catalyst MnO2/CH-FP	278:329	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	4	6	dep	90 min	938:943	arg1	MB					956:957	50 mg L-1 MB	946:957	50 mg L-1 MB	946:957	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	4	6	dep	90 min	938:943	arg1	catalyst					968:975	1 g L-1 catalyst	960:975	1 g L-1 catalyst	960:975	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	4	6	dep	90 min	938:943	arg1	H2O2					988:991	30 mg L-1 H2O2	978:991	30 mg L-1 H2O2	978:991	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	4	6	dep	90 min	938:943	arg1	pH					994:995	pH 7	994:997	pH 7	994:997	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	1	7	theme	pH	394:395	arg1	range					397:401	a wide pH range	387:401	a wide pH range from 2.8 to 11.2	387:418	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	1	8	theme	cellulose	169:177	arg1	FP					193:194	FP	193:194	FP	193:194	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	1	8	theme	cellulose	169:177	arg1	paper					186:190	cellulose filter paper	169:190	cellulose filter paper (FP)	169:195	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	4	9	theme	low-concentration	869:885	arg1	dosages					887:893	multiple low-concentration dosages	860:893	multiple low-concentration dosages of H2O2	860:901	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	0	10	theme	retrievable	95:105	arg1	catalyst					123:130	a retrievable Fenton-like dip catalyst	93:130	a retrievable Fenton-like dip catalyst	93:130	Immobilization of chitosan-templated MnO2 nanoparticles onto filter paper by redox method as a retrievable Fenton-like dip catalyst.
33158502	4	11	theme	catalyst	816:823	arg1	1.0MnO2/CH-FP					825:837	The optimal catalyst 1.0MnO2/CH-FP	804:837	The optimal catalyst 1.0MnO2/CH-FP	804:837	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	1	12	dep	11.2	415:418	arg1	to					412:413	to	412:413	to	412:413	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	3	13	theme	structure-function	720:737	arg1	relationships					739:751	their structure-function relationships	714:751	their structure-function relationships	714:751	A series of MnO2/CH-FP hybrids with different MnO2 loading were fabricated via varying concentration of Mn(NO3)2 solution, and their structure-function relationships were discussed based on detailed characterization.
33158502	4	14	theme	H2O2	898:901	arg1	dosages					887:893	multiple low-concentration dosages	860:893	multiple low-concentration dosages of H2O2	860:901	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	4	15	theme	optimal	808:814	arg1	1.0MnO2/CH-FP					825:837	The optimal catalyst 1.0MnO2/CH-FP	804:837	The optimal catalyst 1.0MnO2/CH-FP	804:837	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	2	16	theme	mild	570:573	arg1	conditions					575:584	mild conditions	570:584	mild conditions	570:584	The MnO2 nanoparticles were uniformly immobilized in the CH-FP matrix by in-situ redox precipitation method where Mn(NO3)2 was treated with KMnO4 at mild conditions.
33158502	6	17	theme	larger	1213:1218	arg1	area					1228:1231	its larger surface area	1209:1231	its larger surface area	1209:1231	Moreover, the activity of this composite greatly surpassed that of bare MnO2 for nearly 50%, owing to its larger surface area and more accessible active sites.
33158502	0	18	theme	dip	119:121	arg1	catalyst					123:130	a retrievable Fenton-like dip catalyst	93:130	a retrievable Fenton-like dip catalyst	93:130	Immobilization of chitosan-templated MnO2 nanoparticles onto filter paper by redox method as a retrievable Fenton-like dip catalyst.
33158502	1	19	theme	Fenton-like	335:345	arg1	degradation					347:357	Fenton-like degradation	335:357	Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2	335:418	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	1	20	theme	filter	179:184	arg1	FP					193:194	FP	193:194	FP	193:194	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	1	20	theme	filter	179:184	arg1	paper					186:190	cellulose filter paper	169:190	cellulose filter paper (FP)	169:195	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	0	21	theme	Fenton-like	107:117	arg1	catalyst					123:130	a retrievable Fenton-like dip catalyst	93:130	a retrievable Fenton-like dip catalyst	93:130	Immobilization of chitosan-templated MnO2 nanoparticles onto filter paper by redox method as a retrievable Fenton-like dip catalyst.
33158502	6	22	theme	surface	1220:1226	arg1	area					1228:1231	its larger surface area	1209:1231	its larger surface area	1209:1231	Moreover, the activity of this composite greatly surpassed that of bare MnO2 for nearly 50%, owing to its larger surface area and more accessible active sites.
33158502	4	23	from	MB	932:933	arg1	90 min					938:943	90 min	938:943	90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7)	938:998	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	1	24	theme	paper	186:190	arg1	hydrophilicity					151:164	the hydrophilicity	147:164	the hydrophilicity of cellulose filter paper (FP)	147:195	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	1	24	theme	paper	186:190	arg1	property					225:232	the excellent chelating property	201:232	the excellent chelating property of chitosan (CH) for Mn2+	201:258	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	4	25	theme	1 g L-1	960:966	arg1	MB					956:957	50 mg L-1 MB	946:957	50 mg L-1 MB	946:957	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	4	25	theme	1 g L-1	960:966	arg1	catalyst					968:975	1 g L-1 catalyst	960:975	1 g L-1 catalyst	960:975	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	5	26	theme	%	1058:1058	arg1	efficiency					1072:1081	83.3% degradation efficiency	1054:1081	83.3% degradation efficiency of MB after six cycles	1054:1104	It is also shown that 1.0MnO2/CH-FP could still keep 83.3% degradation efficiency of MB after six cycles.
33158502	4	27	theme	%	930:930	arg1	MB					932:933	95.6% MB	926:933	95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7)	926:998	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	7	28	theme	MnO2	1349:1352	arg1	nanoparticles					1354:1366	MnO2 nanoparticles	1349:1366	MnO2 nanoparticles	1349:1366	This method for preparing MnO2/CH-FP could effectively avoid the agglomeration of MnO2 nanoparticles and make the reaction turn on/off almost instantaneously by mere insertion/removal.
33158502	3	29	theme	hybrids	610:616	arg1	series					589:594	A series	587:594	A series of MnO2/CH-FP hybrids with different MnO2 loading	587:644	A series of MnO2/CH-FP hybrids with different MnO2 loading were fabricated via varying concentration of Mn(NO3)2 solution, and their structure-function relationships were discussed based on detailed characterization.
33158502	6	30	theme	composite	1138:1146	arg1	activity					1121:1128	the activity	1117:1128	the activity of this composite	1117:1146	Moreover, the activity of this composite greatly surpassed that of bare MnO2 for nearly 50%, owing to its larger surface area and more accessible active sites.
33158502	0	31	theme	MnO2	37:40	arg1	Immobilization					0:13	Immobilization	0:13	Immobilization of chitosan-templated MnO2	0:40	Immobilization of chitosan-templated MnO2 nanoparticles onto filter paper by redox method as a retrievable Fenton-like dip catalyst.
33158502	3	32	theme	Mn	691:692	arg1	solution					700:707	Mn(NO3)2 solution	691:707	Mn(NO3)2 solution	691:707	A series of MnO2/CH-FP hybrids with different MnO2 loading were fabricated via varying concentration of Mn(NO3)2 solution, and their structure-function relationships were discussed based on detailed characterization.
33158502	2	33	theme	redox	502:506	arg1	method					522:527	in-situ redox precipitation method	494:527	in-situ redox precipitation method	494:527	The MnO2 nanoparticles were uniformly immobilized in the CH-FP matrix by in-situ redox precipitation method where Mn(NO3)2 was treated with KMnO4 at mild conditions.
33158502	6	34	theme	accessible	1242:1251	arg1	sites					1260:1264	more accessible active sites	1237:1264	more accessible active sites	1237:1264	Moreover, the activity of this composite greatly surpassed that of bare MnO2 for nearly 50%, owing to its larger surface area and more accessible active sites.
33158502	0	35	theme	chitosan-templated	18:35	arg1	MnO2					37:40	chitosan-templated MnO2	18:40	chitosan-templated MnO2	18:40	Immobilization of chitosan-templated MnO2 nanoparticles onto filter paper by redox method as a retrievable Fenton-like dip catalyst.
33158502	2	36	theme	in-situ	494:500	arg1	method					522:527	in-situ redox precipitation method	494:527	in-situ redox precipitation method	494:527	The MnO2 nanoparticles were uniformly immobilized in the CH-FP matrix by in-situ redox precipitation method where Mn(NO3)2 was treated with KMnO4 at mild conditions.
33158502	1	37	theme	methylene	362:370	arg1	degradation					347:357	Fenton-like degradation	335:357	Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2	335:418	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	7	38	theme	mere	1428:1431	arg1	insertion/removal					1433:1449	mere insertion/removal	1428:1449	mere insertion/removal	1428:1449	This method for preparing MnO2/CH-FP could effectively avoid the agglomeration of MnO2 nanoparticles and make the reaction turn on/off almost instantaneously by mere insertion/removal.
33158502	1	39	theme	blue	372:375	arg1	methylene					362:370	methylene blue	362:375	methylene blue (MB) over a wide pH range from 2.8 to 11.2	362:418	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	1	39	theme	blue	372:375	arg1	MB					378:379	MB	378:379	MB	378:379	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	4	40	theme	50 mg L-1	946:954	arg1	MB					956:957	50 mg L-1 MB	946:957	50 mg L-1 MB	946:957	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	4	40	theme	50 mg L-1	946:954	arg1	catalyst					968:975	1 g L-1 catalyst	960:975	1 g L-1 catalyst	960:975	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	4	40	theme	50 mg L-1	946:954	arg1	H2O2					988:991	30 mg L-1 H2O2	978:991	30 mg L-1 H2O2	978:991	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	4	40	theme	50 mg L-1	946:954	arg1	pH					994:995	pH 7	994:997	pH 7	994:997	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	7	41	theme	nanoparticles	1354:1366	arg1	agglomeration					1332:1344	the agglomeration	1328:1344	the agglomeration of MnO2 nanoparticles	1328:1366	This method for preparing MnO2/CH-FP could effectively avoid the agglomeration of MnO2 nanoparticles and make the reaction turn on/off almost instantaneously by mere insertion/removal.
33158502	1	42	theme	excellent	205:213	arg1	property					225:232	the excellent chelating property	201:232	the excellent chelating property of chitosan (CH) for Mn2+	201:258	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	2	43	theme	CH-FP	478:482	arg1	matrix					484:489	the CH-FP matrix	474:489	the CH-FP matrix	474:489	The MnO2 nanoparticles were uniformly immobilized in the CH-FP matrix by in-situ redox precipitation method where Mn(NO3)2 was treated with KMnO4 at mild conditions.
33158502	2	44	theme	Mn	535:536	arg1	NO3					538:540	Mn(NO3)2	535:542	Mn(NO3)2	535:542	The MnO2 nanoparticles were uniformly immobilized in the CH-FP matrix by in-situ redox precipitation method where Mn(NO3)2 was treated with KMnO4 at mild conditions.
33158502	5	45	theme	MB	1086:1087	arg1	efficiency					1072:1081	83.3% degradation efficiency	1054:1081	83.3% degradation efficiency of MB after six cycles	1054:1104	It is also shown that 1.0MnO2/CH-FP could still keep 83.3% degradation efficiency of MB after six cycles.
33158502	0	46	theme	filter	61:66	arg1	paper					68:72	filter paper	61:72	filter paper	61:72	Immobilization of chitosan-templated MnO2 nanoparticles onto filter paper by redox method as a retrievable Fenton-like dip catalyst.
33158502	1	47	theme	efficient	281:289	arg1	catalyst					311:318	an efficient and retrievable dip catalyst	278:318	an efficient and retrievable dip catalyst MnO2/CH-FP	278:329	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	3	48	theme	different	623:631	arg1	loading					638:644	different MnO2 loading	623:644	different MnO2 loading	623:644	A series of MnO2/CH-FP hybrids with different MnO2 loading were fabricated via varying concentration of Mn(NO3)2 solution, and their structure-function relationships were discussed based on detailed characterization.
33158502	7	49	theme	on/off	1395:1400	arg1	turn					1390:1393	the reaction turn on/off	1377:1400	the reaction turn on/off	1377:1400	This method for preparing MnO2/CH-FP could effectively avoid the agglomeration of MnO2 nanoparticles and make the reaction turn on/off almost instantaneously by mere insertion/removal.
33158502	5	50	theme	83.3	1054:1057	arg1	%					1058:1058	%	1058:1058	%	1058:1058	It is also shown that 1.0MnO2/CH-FP could still keep 83.3% degradation efficiency of MB after six cycles.
33158502	6	51	theme	bare	1174:1177	arg1	MnO2					1179:1182	bare MnO2	1174:1182	bare MnO2	1174:1182	Moreover, the activity of this composite greatly surpassed that of bare MnO2 for nearly 50%, owing to its larger surface area and more accessible active sites.
33158502	3	52	theme	detailed	777:784	arg1	characterization					786:801	detailed characterization	777:801	detailed characterization	777:801	A series of MnO2/CH-FP hybrids with different MnO2 loading were fabricated via varying concentration of Mn(NO3)2 solution, and their structure-function relationships were discussed based on detailed characterization.
33158502	3	53	theme	NO3	694:696	arg1	solution					700:707	Mn(NO3)2 solution	691:707	Mn(NO3)2 solution	691:707	A series of MnO2/CH-FP hybrids with different MnO2 loading were fabricated via varying concentration of Mn(NO3)2 solution, and their structure-function relationships were discussed based on detailed characterization.
33158502	3	54	theme	MnO2/CH-FP	599:608	arg1	hybrids					610:616	MnO2/CH-FP hybrids	599:616	MnO2/CH-FP hybrids with different MnO2 loading	599:644	A series of MnO2/CH-FP hybrids with different MnO2 loading were fabricated via varying concentration of Mn(NO3)2 solution, and their structure-function relationships were discussed based on detailed characterization.
33158502	1	55	theme	chelating	215:223	arg1	property					225:232	the excellent chelating property	201:232	the excellent chelating property of chitosan (CH) for Mn2+	201:258	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	2	56	theme	precipitation	508:520	arg1	method					522:527	in-situ redox precipitation method	494:527	in-situ redox precipitation method	494:527	The MnO2 nanoparticles were uniformly immobilized in the CH-FP matrix by in-situ redox precipitation method where Mn(NO3)2 was treated with KMnO4 at mild conditions.
33158502	7	57	theme	reaction	1381:1388	arg1	turn					1390:1393	the reaction turn on/off	1377:1400	the reaction turn on/off	1377:1400	This method for preparing MnO2/CH-FP could effectively avoid the agglomeration of MnO2 nanoparticles and make the reaction turn on/off almost instantaneously by mere insertion/removal.
33158502	1	58	from	11.2	415:418	arg1	range					397:401	a wide pH range	387:401	a wide pH range from 2.8 to 11.2	387:418	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	4	59	theme	multiple	860:867	arg1	dosages					887:893	multiple low-concentration dosages	860:893	multiple low-concentration dosages of H2O2	860:901	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	0	60	theme	redox	77:81	arg1	method					83:88	redox method	77:88	redox method	77:88	Immobilization of chitosan-templated MnO2 nanoparticles onto filter paper by redox method as a retrievable Fenton-like dip catalyst.
33158502	1	61	theme	wide	389:392	arg1	range					397:401	a wide pH range	387:401	a wide pH range from 2.8 to 11.2	387:418	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	3	62	theme	solution	700:707	arg1	concentration					674:686	concentration	674:686	concentration of Mn(NO3)2 solution	674:707	A series of MnO2/CH-FP hybrids with different MnO2 loading were fabricated via varying concentration of Mn(NO3)2 solution, and their structure-function relationships were discussed based on detailed characterization.
33158502	4	63	theme	95.6	926:929	arg1	%					930:930	%	930:930	%	930:930	The optimal catalyst 1.0MnO2/CH-FP could cooperate with multiple low-concentration dosages of H2O2 to efficiently degrade 95.6% MB in 90 min (50 mg L-1 MB, 1 g L-1 catalyst, 30 mg L-1 H2O2, pH 7).
33158502	1	64	theme	retrievable	295:305	arg1	catalyst					311:318	an efficient and retrievable dip catalyst	278:318	an efficient and retrievable dip catalyst MnO2/CH-FP	278:329	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	3	65	theme	MnO2	633:636	arg1	loading					638:644	different MnO2 loading	623:644	different MnO2 loading	623:644	A series of MnO2/CH-FP hybrids with different MnO2 loading were fabricated via varying concentration of Mn(NO3)2 solution, and their structure-function relationships were discussed based on detailed characterization.
33158502	3	66	with	hybrids	610:616	arg1	loading					638:644	different MnO2 loading	623:644	different MnO2 loading	623:644	A series of MnO2/CH-FP hybrids with different MnO2 loading were fabricated via varying concentration of Mn(NO3)2 solution, and their structure-function relationships were discussed based on detailed characterization.
33158502	1	67	theme	chitosan	237:244	arg1	hydrophilicity					151:164	the hydrophilicity	147:164	the hydrophilicity of cellulose filter paper (FP)	147:195	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
33158502	1	67	theme	chitosan	237:244	arg1	property					225:232	the excellent chelating property	201:232	the excellent chelating property of chitosan (CH) for Mn2+	201:258	By exploiting the hydrophilicity of cellulose filter paper (FP) and the excellent chelating property of chitosan (CH) for Mn2+, we have designed an efficient and retrievable dip catalyst MnO2/CH-FP for Fenton-like degradation of methylene blue (MB) over a wide pH range from 2.8 to 11.2.
32475546	0	0	theme	composite	91:99	arg1	films					101:105	PVA/starch composite films	80:105	PVA/starch composite films for packaging applications	80:132	Thermal decomposition kinetics and properties of grafted barley husk reinforced PVA/starch composite films for packaging applications.
32475546	0	1	theme	PVA/starch	80:89	arg1	films					101:105	PVA/starch composite films	80:105	PVA/starch composite films for packaging applications	80:132	Thermal decomposition kinetics and properties of grafted barley husk reinforced PVA/starch composite films for packaging applications.
32475546	4	2	theme	mechanical	797:806	arg1	performance					808:818	the mechanical performance	793:818	the mechanical performance of the films	793:831	Incorporation of grafted BH into crosslinked PVA/starch matrix improved the mechanical performance of the films compared to BH and showed 30 % increase in tensile strength after reinforcement.
32475546	1	3	theme	thermogravimetric	181:197	arg1	curves					205:210	thermogravimetric (TGA) curves	181:210	thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min)	181:426	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	1	3	theme	thermogravimetric	181:197	arg1	TGA					200:202	TGA	200:202	TGA	200:202	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	2	4	theme	Flynn-Wall-Ozawa	492:507	arg1	KAS					541:543	KAS	541:543	KAS	541:543	The activation energy for composite films was determined using Flynn-Wall-Ozawa (FWO) Kissinger-Akahira-Sunose (KAS), Friedman (FR) and modified Coasts Redfern (CR) methods.
32475546	2	4	theme	Flynn-Wall-Ozawa	492:507	arg1	Kissinger-Akahira-Sunose					515:538	Flynn-Wall-Ozawa (FWO) Kissinger-Akahira-Sunose	492:538	Flynn-Wall-Ozawa (FWO) Kissinger-Akahira-Sunose (KAS)	492:544	The activation energy for composite films was determined using Flynn-Wall-Ozawa (FWO) Kissinger-Akahira-Sunose (KAS), Friedman (FR) and modified Coasts Redfern (CR) methods.
32475546	3	5	theme	activation	627:636	arg1	energy					638:643	activation energy	627:643	activation energy for thermal degradation of grafted BH composite film	627:696	The results showed that activation energy for thermal degradation of grafted BH composite film was higher than of BH.
32475546	4	6	theme	films	827:831	arg1	performance					808:818	the mechanical performance	793:818	the mechanical performance of the films	793:831	Incorporation of grafted BH into crosslinked PVA/starch matrix improved the mechanical performance of the films compared to BH and showed 30 % increase in tensile strength after reinforcement.
32475546	6	7	theme	polymer	1136:1142	arg1	matrix					1144:1149	the polymer matrix	1132:1149	the polymer matrix	1132:1149	Biodegradability of the films improved significantly after incorporation of BH into the polymer matrix and showed 70 % degradation after 180 days.
32475546	5	8	theme	packaging	1024:1032	arg1	applications					1034:1045	packaging applications	1024:1045	packaging applications	1024:1045	Grafted BH composite films showed higher barrier properties for light, water vapor and oxygen as required for packaging applications.
32475546	1	9	link	crosslinked	215:225	arg1	films					248:252	crosslinked PVA/starch composite films	215:252	crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid)	215:320	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	2	10	dep	Kissinger-Akahira-Sunose	515:538	arg1	methods					594:600	methods	594:600	methods	594:600	The activation energy for composite films was determined using Flynn-Wall-Ozawa (FWO) Kissinger-Akahira-Sunose (KAS), Friedman (FR) and modified Coasts Redfern (CR) methods.
32475546	3	11	theme	grafted	672:678	arg1	film					693:696	grafted BH composite film	672:696	grafted BH composite film	672:696	The results showed that activation energy for thermal degradation of grafted BH composite film was higher than of BH.
32475546	5	12	theme	Grafted	914:920	arg1	films					935:939	Grafted BH composite films	914:939	Grafted BH composite films	914:939	Grafted BH composite films showed higher barrier properties for light, water vapor and oxygen as required for packaging applications.
32475546	6	13	theme	films	1072:1076	arg1	Biodegradability					1048:1063	Biodegradability	1048:1063	Biodegradability of the films	1048:1076	Biodegradability of the films improved significantly after incorporation of BH into the polymer matrix and showed 70 % degradation after 180 days.
32475546	0	14	theme	packaging	111:119	arg1	applications					121:132	packaging applications	111:132	packaging applications	111:132	Thermal decomposition kinetics and properties of grafted barley husk reinforced PVA/starch composite films for packaging applications.
32475546	1	15	theme	inert	356:360	arg1	atmosphere					362:371	an inert atmosphere	353:371	an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min)	353:426	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	2	16	theme	Coasts	574:579	arg1	CR					590:591	CR	590:591	CR	590:591	The activation energy for composite films was determined using Flynn-Wall-Ozawa (FWO) Kissinger-Akahira-Sunose (KAS), Friedman (FR) and modified Coasts Redfern (CR) methods.
32475546	2	16	theme	Coasts	574:579	arg1	Redfern					581:587	modified Coasts Redfern	565:587	modified Coasts Redfern (CR)	565:592	The activation energy for composite films was determined using Flynn-Wall-Ozawa (FWO) Kissinger-Akahira-Sunose (KAS), Friedman (FR) and modified Coasts Redfern (CR) methods.
32475546	5	17	theme	BH	922:923	arg1	films					935:939	Grafted BH composite films	914:939	Grafted BH composite films	914:939	Grafted BH composite films showed higher barrier properties for light, water vapor and oxygen as required for packaging applications.
32475546	4	18	link	crosslinked	754:764	arg1	matrix					777:782	crosslinked PVA/starch matrix	754:782	crosslinked PVA/starch matrix	754:782	Incorporation of grafted BH into crosslinked PVA/starch matrix improved the mechanical performance of the films compared to BH and showed 30 % increase in tensile strength after reinforcement.
32475546	0	19	theme	decomposition	8:20	arg1	kinetics					22:29	Thermal decomposition kinetics	0:29	Thermal decomposition kinetics	0:29	Thermal decomposition kinetics and properties of grafted barley husk reinforced PVA/starch composite films for packaging applications.
32475546	2	20	theme	modified	565:572	arg1	CR					590:591	CR	590:591	CR	590:591	The activation energy for composite films was determined using Flynn-Wall-Ozawa (FWO) Kissinger-Akahira-Sunose (KAS), Friedman (FR) and modified Coasts Redfern (CR) methods.
32475546	2	20	theme	modified	565:572	arg1	Redfern					581:587	modified Coasts Redfern	565:587	modified Coasts Redfern (CR)	565:592	The activation energy for composite films was determined using Flynn-Wall-Ozawa (FWO) Kissinger-Akahira-Sunose (KAS), Friedman (FR) and modified Coasts Redfern (CR) methods.
32475546	4	21	theme	tensile	876:882	arg1	strength					884:891	tensile strength	876:891	tensile strength	876:891	Incorporation of grafted BH into crosslinked PVA/starch matrix improved the mechanical performance of the films compared to BH and showed 30 % increase in tensile strength after reinforcement.
32475546	0	22	theme	Thermal	0:6	arg1	kinetics					22:29	Thermal decomposition kinetics	0:29	Thermal decomposition kinetics	0:29	Thermal decomposition kinetics and properties of grafted barley husk reinforced PVA/starch composite films for packaging applications.
32475546	3	23	theme	film	693:696	arg1	degradation					657:667	thermal degradation	649:667	thermal degradation of grafted BH composite film	649:696	The results showed that activation energy for thermal degradation of grafted BH composite film was higher than of BH.
32475546	1	24	theme	grafted	291:297	arg1	BH					299:300	grafted BH	291:300	grafted BH (using lauric acid)	291:320	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	6	25	theme	%	1165:1165	arg1	degradation					1167:1177	70 % degradation	1162:1177	70 % degradation	1162:1177	Biodegradability of the films improved significantly after incorporation of BH into the polymer matrix and showed 70 % degradation after 180 days.
32475546	3	26	theme	BH	680:681	arg1	film					693:696	grafted BH composite film	672:696	grafted BH composite film	672:696	The results showed that activation energy for thermal degradation of grafted BH composite film was higher than of BH.
32475546	4	27	from	increase	864:871	arg1	strength					884:891	tensile strength	876:891	tensile strength	876:891	Incorporation of grafted BH into crosslinked PVA/starch matrix improved the mechanical performance of the films compared to BH and showed 30 % increase in tensile strength after reinforcement.
32475546	1	28	theme	crosslinked	215:225	arg1	films					248:252	crosslinked PVA/starch composite films	215:252	crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid)	215:320	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	2	29	theme	activation	433:442	arg1	energy					444:449	The activation energy	429:449	The activation energy for composite films	429:469	The activation energy for composite films was determined using Flynn-Wall-Ozawa (FWO) Kissinger-Akahira-Sunose (KAS), Friedman (FR) and modified Coasts Redfern (CR) methods.
32475546	3	30	theme	composite	683:691	arg1	film					693:696	grafted BH composite film	672:696	grafted BH composite film	672:696	The results showed that activation energy for thermal degradation of grafted BH composite film was higher than of BH.
32475546	1	31	theme	different	378:386	arg1	20 °C/min					417:425	5, 10, 15 and 20 °C/min	403:425	5, 10, 15 and 20 °C/min	403:425	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	1	31	theme	different	378:386	arg1	rates					396:400	different heating rates	378:400	different heating rates (5, 10, 15 and 20 °C/min)	378:426	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	5	32	theme	barrier	955:961	arg1	properties					963:972	higher barrier properties	948:972	higher barrier properties for light, water vapor and oxygen	948:1006	Grafted BH composite films showed higher barrier properties for light, water vapor and oxygen as required for packaging applications.
32475546	1	33	theme	PVA/starch	227:236	arg1	films					248:252	crosslinked PVA/starch composite films	215:252	crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid)	215:320	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	4	34	theme	%	862:862	arg1	increase					864:871	30 % increase	859:871	30 % increase in tensile strength	859:891	Incorporation of grafted BH into crosslinked PVA/starch matrix improved the mechanical performance of the films compared to BH and showed 30 % increase in tensile strength after reinforcement.
32475546	1	35	theme	heating	388:394	arg1	20 °C/min					417:425	5, 10, 15 and 20 °C/min	403:425	5, 10, 15 and 20 °C/min	403:425	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	1	35	theme	heating	388:394	arg1	rates					396:400	different heating rates	378:400	different heating rates (5, 10, 15 and 20 °C/min)	378:426	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	4	36	theme	BH	746:747	arg1	Incorporation					721:733	Incorporation	721:733	Incorporation of grafted BH into crosslinked PVA/starch matrix	721:782	Incorporation of grafted BH into crosslinked PVA/starch matrix improved the mechanical performance of the films compared to BH and showed 30 % increase in tensile strength after reinforcement.
32475546	1	37	theme	composite	238:246	arg1	films					248:252	crosslinked PVA/starch composite films	215:252	crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid)	215:320	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	0	38	theme	barley	57:62	arg1	husk					64:67	grafted barley husk	49:67	grafted barley husk	49:67	Thermal decomposition kinetics and properties of grafted barley husk reinforced PVA/starch composite films for packaging applications.
32475546	1	39	theme	lauric	309:314	arg1	acid					316:319	lauric acid	309:319	lauric acid	309:319	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	2	40	theme	composite	455:463	arg1	films					465:469	composite films	455:469	composite films	455:469	The activation energy for composite films was determined using Flynn-Wall-Ozawa (FWO) Kissinger-Akahira-Sunose (KAS), Friedman (FR) and modified Coasts Redfern (CR) methods.
32475546	4	41	theme	PVA/starch	766:775	arg1	matrix					777:782	crosslinked PVA/starch matrix	754:782	crosslinked PVA/starch matrix	754:782	Incorporation of grafted BH into crosslinked PVA/starch matrix improved the mechanical performance of the films compared to BH and showed 30 % increase in tensile strength after reinforcement.
32475546	3	42	theme	thermal	649:655	arg1	degradation					657:667	thermal degradation	649:667	thermal degradation of grafted BH composite film	649:696	The results showed that activation energy for thermal degradation of grafted BH composite film was higher than of BH.
32475546	0	43	theme	grafted	49:55	arg1	husk					64:67	grafted barley husk	49:67	grafted barley husk	49:67	Thermal decomposition kinetics and properties of grafted barley husk reinforced PVA/starch composite films for packaging applications.
32475546	4	44	theme	crosslinked	754:764	arg1	matrix					777:782	crosslinked PVA/starch matrix	754:782	crosslinked PVA/starch matrix	754:782	Incorporation of grafted BH into crosslinked PVA/starch matrix improved the mechanical performance of the films compared to BH and showed 30 % increase in tensile strength after reinforcement.
32475546	1	45	theme	Thermal	135:141	arg1	kinetics					155:162	Thermal degradation kinetics	135:162	Thermal degradation kinetics	135:162	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	5	46	theme	water	985:989	arg1	vapor					991:995	water vapor	985:995	water vapor	985:995	Grafted BH composite films showed higher barrier properties for light, water vapor and oxygen as required for packaging applications.
32475546	5	47	theme	composite	925:933	arg1	films					935:939	Grafted BH composite films	914:939	Grafted BH composite films	914:939	Grafted BH composite films showed higher barrier properties for light, water vapor and oxygen as required for packaging applications.
32475546	1	48	theme	degradation	143:153	arg1	kinetics					155:162	Thermal degradation kinetics	135:162	Thermal degradation kinetics	135:162	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	1	49	with	atmosphere	362:371	arg1	20 °C/min					417:425	5, 10, 15 and 20 °C/min	403:425	5, 10, 15 and 20 °C/min	403:425	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	1	49	with	atmosphere	362:371	arg1	rates					396:400	different heating rates	378:400	different heating rates (5, 10, 15 and 20 °C/min)	378:426	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	1	50	theme	films	248:252	arg1	curves					205:210	thermogravimetric (TGA) curves	181:210	thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min)	181:426	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	1	50	theme	films	248:252	arg1	TGA					200:202	TGA	200:202	TGA	200:202	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	6	51	theme	BH	1124:1125	arg1	incorporation					1107:1119	incorporation	1107:1119	incorporation of BH into the polymer matrix	1107:1149	Biodegradability of the films improved significantly after incorporation of BH into the polymer matrix and showed 70 % degradation after 180 days.
32475546	4	52	theme	grafted	738:744	arg1	BH					746:747	grafted BH	738:747	grafted BH	738:747	Incorporation of grafted BH into crosslinked PVA/starch matrix improved the mechanical performance of the films compared to BH and showed 30 % increase in tensile strength after reinforcement.
32475546	0	53	theme	husk	64:67	arg1	kinetics					22:29	Thermal decomposition kinetics	0:29	Thermal decomposition kinetics	0:29	Thermal decomposition kinetics and properties of grafted barley husk reinforced PVA/starch composite films for packaging applications.
32475546	0	53	theme	husk	64:67	arg1	properties					35:44	properties	35:44	properties	35:44	Thermal decomposition kinetics and properties of grafted barley husk reinforced PVA/starch composite films for packaging applications.
32475546	5	54	theme	higher	948:953	arg1	properties					963:972	higher barrier properties	948:972	higher barrier properties for light, water vapor and oxygen	948:1006	Grafted BH composite films showed higher barrier properties for light, water vapor and oxygen as required for packaging applications.
32475546	6	55	theme	70	1162:1163	arg1	%					1165:1165	%	1165:1165	%	1165:1165	Biodegradability of the films improved significantly after incorporation of BH into the polymer matrix and showed 70 % degradation after 180 days.
32475546	1	56	theme	barley	270:275	arg1	BH					283:284	BH	283:284	BH	283:284	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
32475546	1	56	theme	barley	270:275	arg1	husk					277:280	barley husk	270:280	barley husk (BH)	270:285	Thermal degradation kinetics was performed on thermogravimetric (TGA) curves of crosslinked PVA/starch composite films reinforced with barley husk (BH) and grafted BH (using lauric acid) obtained by heating samples in an inert atmosphere with different heating rates (5, 10, 15 and 20 °C/min).
33092921	6	0	theme	structures	835:844	arg1	dismission					767:776	The dismission	763:776	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min	763:879	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min indicated that the structural evolution of starch in rice kernels was time- and temperature-dependent.
33092921	5	1	theme	kernels	625:631	arg1	Mw					614:615	The Mw	610:615	The Mw of rice kernels at different cooking temperatures and times	610:675	The Mw of rice kernels at different cooking temperatures and times was similar, but the molecular size and volume varied at different stages of cooking.
33092921	5	1	theme	kernels	625:631	arg1	similar					681:687	similar	681:687	similar	681:687	The Mw of rice kernels at different cooking temperatures and times was similar, but the molecular size and volume varied at different stages of cooking.
33092921	1	2	theme	kernels	126:132	arg1	composition					106:116	composition	106:116	composition	106:116	The content and composition of rice kernels are closely related to the textural properties of cooked rice.
33092921	1	2	theme	kernels	126:132	arg1	content					94:100	content	94:100	content	94:100	The content and composition of rice kernels are closely related to the textural properties of cooked rice.
33092921	6	3	theme	starch	924:929	arg1	time-					951:955	time-	951:955	time-	951:955	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min indicated that the structural evolution of starch in rice kernels was time- and temperature-dependent.
33092921	6	3	theme	starch	924:929	arg1	evolution					911:919	the structural evolution	896:919	the structural evolution of starch in rice kernels	896:945	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min indicated that the structural evolution of starch in rice kernels was time- and temperature-dependent.
33092921	0	4	theme	textural	55:62	arg1	formation					64:72	the textural formation	51:72	the textural formation of cooked rice	51:87	Effect of structure evolution of starch in rice on the textural formation of cooked rice.
33092921	6	5	theme	lamellar	826:833	arg1	structures					835:844	lamellar structures	826:844	lamellar structures	826:844	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min indicated that the structural evolution of starch in rice kernels was time- and temperature-dependent.
33092921	7	6	theme	rice	1066:1069	arg1	cooking					1071:1077	rice cooking	1066:1077	rice cooking	1066:1077	These results provide a promising foundation for developing strategies to control rice cooking.
33092921	5	7	from	temperatures	654:665	arg1	Mw					614:615	The Mw	610:615	The Mw of rice kernels at different cooking temperatures and times	610:675	The Mw of rice kernels at different cooking temperatures and times was similar, but the molecular size and volume varied at different stages of cooking.
33092921	5	7	from	temperatures	654:665	arg1	similar					681:687	similar	681:687	similar	681:687	The Mw of rice kernels at different cooking temperatures and times was similar, but the molecular size and volume varied at different stages of cooking.
33092921	0	8	theme	cooked	77:82	arg1	rice					84:87	cooked rice	77:87	cooked rice	77:87	Effect of structure evolution of starch in rice on the textural formation of cooked rice.
33092921	0	9	from	Effect	0:5	arg1	formation					64:72	the textural formation	51:72	the textural formation of cooked rice	51:87	Effect of structure evolution of starch in rice on the textural formation of cooked rice.
33092921	0	9	from	Effect	0:5	arg1	rice					43:46	rice	43:46	rice	43:46	Effect of structure evolution of starch in rice on the textural formation of cooked rice.
33092921	2	10	theme	changes	253:259	arg1	explanations					228:239	the mechanistic explanations	212:239	the mechanistic explanations of textural changes	212:259	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	0	11	from	rice	43:46	arg1	Effect					0:5	Effect	0:5	Effect of structure evolution of starch in rice on the textural formation of cooked rice.	0:88	Effect of structure evolution of starch in rice on the textural formation of cooked rice.
33092921	6	12	theme	structural	900:909	arg1	time-					951:955	time-	951:955	time-	951:955	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min indicated that the structural evolution of starch in rice kernels was time- and temperature-dependent.
33092921	6	12	theme	structural	900:909	arg1	evolution					911:919	the structural evolution	896:919	the structural evolution of starch in rice kernels	896:945	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min indicated that the structural evolution of starch in rice kernels was time- and temperature-dependent.
33092921	2	13	theme	textural	244:251	arg1	changes					253:259	textural changes	244:259	textural changes	244:259	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	4	14	theme	starch	531:536	arg1	weight					516:521	The molecular weight	502:521	The molecular weight (Mw) of starch and protein in leached solids	502:566	The molecular weight (Mw) of starch and protein in leached solids increased with the leaching at 70-100 °C.
33092921	4	14	theme	starch	531:536	arg1	Mw					524:525	Mw	524:525	Mw	524:525	The molecular weight (Mw) of starch and protein in leached solids increased with the leaching at 70-100 °C.
33092921	6	15	theme	resonance	811:819	arg1	dismission					767:776	The dismission	763:776	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min	763:879	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min indicated that the structural evolution of starch in rice kernels was time- and temperature-dependent.
33092921	6	16	from	evolution	911:919	arg1	kernels					939:945	rice kernels	934:945	rice kernels	934:945	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min indicated that the structural evolution of starch in rice kernels was time- and temperature-dependent.
33092921	2	17	theme	components	347:356	arg1	mobility					283:290	proton mobility	276:290	proton mobility	276:290	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	2	17	theme	components	347:356	arg1	behavior					302:309	leaching behavior	293:309	leaching behavior	293:309	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	2	17	theme	components	347:356	arg1	features					330:337	the molecular features	316:337	the molecular features of rice components during cooking	316:371	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	0	18	theme	rice	84:87	arg1	formation					64:72	the textural formation	51:72	the textural formation of cooked rice	51:87	Effect of structure evolution of starch in rice on the textural formation of cooked rice.
33092921	6	19	theme	C1	808:809	arg1	resonance					811:819	C1 resonance	808:819	C1 resonance	808:819	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min indicated that the structural evolution of starch in rice kernels was time- and temperature-dependent.
33092921	1	20	dep	content	94:100	arg1	The					90:92	The	90:92	The	90:92	The content and composition of rice kernels are closely related to the textural properties of cooked rice.
33092921	2	21	theme	rice	342:345	arg1	components					347:356	rice components	342:356	rice components	342:356	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	5	22	theme	molecular	698:706	arg1	size					708:711	the molecular size	694:711	the molecular size	694:711	The Mw of rice kernels at different cooking temperatures and times was similar, but the molecular size and volume varied at different stages of cooking.
33092921	7	23	theme	promising	1008:1016	arg1	foundation					1018:1027	a promising foundation	1006:1027	a promising foundation for developing strategies to control rice cooking	1006:1077	These results provide a promising foundation for developing strategies to control rice cooking.
33092921	2	24	theme	proton	276:281	arg1	mobility					283:290	proton mobility	276:290	proton mobility	276:290	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	6	25	from	100 °C	863:868	arg1	cooking					852:858	cooking	852:858	cooking at 100 °C for 10 min	852:879	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min indicated that the structural evolution of starch in rice kernels was time- and temperature-dependent.
33092921	3	26	theme	decreasing	378:387	arg1	trend					389:393	The decreasing trend	374:393	The decreasing trend of hardness	374:405	The decreasing trend of hardness and the formation of stickiness was mainly determined by the molecular mobility of components.
33092921	5	27	theme	different	734:742	arg1	stages					744:749	different stages	734:749	different stages of cooking	734:760	The Mw of rice kernels at different cooking temperatures and times was similar, but the molecular size and volume varied at different stages of cooking.
33092921	0	28	theme	evolution	20:28	arg1	Effect					0:5	Effect	0:5	Effect of structure evolution of starch in rice on the textural formation of cooked rice.	0:88	Effect of structure evolution of starch in rice on the textural formation of cooked rice.
33092921	4	29	theme	molecular	506:514	arg1	weight					516:521	The molecular weight	502:521	The molecular weight (Mw) of starch and protein in leached solids	502:566	The molecular weight (Mw) of starch and protein in leached solids increased with the leaching at 70-100 °C.
33092921	4	29	theme	molecular	506:514	arg1	Mw					524:525	Mw	524:525	Mw	524:525	The molecular weight (Mw) of starch and protein in leached solids increased with the leaching at 70-100 °C.
33092921	1	30	theme	textural	161:168	arg1	properties					170:179	the textural properties	157:179	the textural properties of cooked rice	157:194	The content and composition of rice kernels are closely related to the textural properties of cooked rice.
33092921	0	31	theme	structure	10:18	arg1	evolution					20:28	structure evolution	10:28	structure evolution of starch in rice	10:46	Effect of structure evolution of starch in rice on the textural formation of cooked rice.
33092921	5	32	theme	different	636:644	arg1	temperatures					654:665	different cooking temperatures	636:665	different cooking temperatures	636:665	The Mw of rice kernels at different cooking temperatures and times was similar, but the molecular size and volume varied at different stages of cooking.
33092921	6	33	theme	structure	797:805	arg1	dismission					767:776	The dismission	763:776	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min	763:879	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min indicated that the structural evolution of starch in rice kernels was time- and temperature-dependent.
33092921	3	34	theme	molecular	468:476	arg1	mobility					478:485	the molecular mobility	464:485	the molecular mobility of components	464:499	The decreasing trend of hardness and the formation of stickiness was mainly determined by the molecular mobility of components.
33092921	0	35	theme	starch	33:38	arg1	evolution					20:28	structure evolution	10:28	structure evolution of starch in rice	10:46	Effect of structure evolution of starch in rice on the textural formation of cooked rice.
33092921	2	36	attach	linked	266:271	arg2	explanations					228:239	the mechanistic explanations	212:239	the mechanistic explanations of textural changes	212:259	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	2	36	attach	linked	266:271	arg1	features					330:337	the molecular features	316:337	the molecular features of rice components during cooking	316:371	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	2	36	attach	linked	266:271	arg1	behavior					302:309	leaching behavior	293:309	leaching behavior	293:309	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	2	36	attach	linked	266:271	arg3	study					205:209	this study	200:209	this study	200:209	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	2	36	attach	linked	266:271	arg1	mobility					283:290	proton mobility	276:290	proton mobility	276:290	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	5	37	theme	cooking	646:652	arg1	temperatures					654:665	different cooking temperatures	636:665	different cooking temperatures	636:665	The Mw of rice kernels at different cooking temperatures and times was similar, but the molecular size and volume varied at different stages of cooking.
33092921	6	38	theme	crystalline	785:795	arg1	structure					797:805	the crystalline structure	781:805	the crystalline structure	781:805	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min indicated that the structural evolution of starch in rice kernels was time- and temperature-dependent.
33092921	4	39	from	weight	516:521	arg1	solids					561:566	leached solids	553:566	leached solids	553:566	The molecular weight (Mw) of starch and protein in leached solids increased with the leaching at 70-100 °C.
33092921	1	40	theme	cooked	184:189	arg1	rice					191:194	cooked rice	184:194	cooked rice	184:194	The content and composition of rice kernels are closely related to the textural properties of cooked rice.
33092921	5	41	from	times	671:675	arg1	Mw					614:615	The Mw	610:615	The Mw of rice kernels at different cooking temperatures and times	610:675	The Mw of rice kernels at different cooking temperatures and times was similar, but the molecular size and volume varied at different stages of cooking.
33092921	5	41	from	times	671:675	arg1	similar					681:687	similar	681:687	similar	681:687	The Mw of rice kernels at different cooking temperatures and times was similar, but the molecular size and volume varied at different stages of cooking.
33092921	2	42	theme	leaching	293:300	arg1	behavior					302:309	leaching behavior	293:309	leaching behavior	293:309	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	5	43	theme	rice	620:623	arg1	kernels					625:631	rice kernels	620:631	rice kernels	620:631	The Mw of rice kernels at different cooking temperatures and times was similar, but the molecular size and volume varied at different stages of cooking.
33092921	2	44	theme	mechanistic	216:226	arg1	explanations					228:239	the mechanistic explanations	212:239	the mechanistic explanations of textural changes	212:259	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	3	45	theme	stickiness	428:437	arg1	formation					415:423	the formation	411:423	the formation of stickiness	411:437	The decreasing trend of hardness and the formation of stickiness was mainly determined by the molecular mobility of components.
33092921	3	45	theme	stickiness	428:437	arg1	trend					389:393	The decreasing trend	374:393	The decreasing trend of hardness	374:405	The decreasing trend of hardness and the formation of stickiness was mainly determined by the molecular mobility of components.
33092921	1	46	theme	rice	191:194	arg1	properties					170:179	the textural properties	157:179	the textural properties of cooked rice	157:194	The content and composition of rice kernels are closely related to the textural properties of cooked rice.
33092921	3	47	theme	components	490:499	arg1	mobility					478:485	the molecular mobility	464:485	the molecular mobility of components	464:499	The decreasing trend of hardness and the formation of stickiness was mainly determined by the molecular mobility of components.
33092921	4	48	theme	protein	542:548	arg1	weight					516:521	The molecular weight	502:521	The molecular weight (Mw) of starch and protein in leached solids	502:566	The molecular weight (Mw) of starch and protein in leached solids increased with the leaching at 70-100 °C.
33092921	4	48	theme	protein	542:548	arg1	Mw					524:525	Mw	524:525	Mw	524:525	The molecular weight (Mw) of starch and protein in leached solids increased with the leaching at 70-100 °C.
33092921	5	49	theme	cooking	754:760	arg1	stages					744:749	different stages	734:749	different stages of cooking	734:760	The Mw of rice kernels at different cooking temperatures and times was similar, but the molecular size and volume varied at different stages of cooking.
33092921	2	50	theme	molecular	320:328	arg1	features					330:337	the molecular features	316:337	the molecular features of rice components during cooking	316:371	In this study, the mechanistic explanations of textural changes were linked to proton mobility, leaching behavior, and the molecular features of rice components during cooking.
33092921	3	51	theme	hardness	398:405	arg1	formation					415:423	the formation	411:423	the formation of stickiness	411:437	The decreasing trend of hardness and the formation of stickiness was mainly determined by the molecular mobility of components.
33092921	3	51	theme	hardness	398:405	arg1	trend					389:393	The decreasing trend	374:393	The decreasing trend of hardness	374:405	The decreasing trend of hardness and the formation of stickiness was mainly determined by the molecular mobility of components.
33092921	6	52	theme	rice	934:937	arg1	kernels					939:945	rice kernels	934:945	rice kernels	934:945	The dismission of the crystalline structure, C1 resonance, and lamellar structures after cooking at 100 °C for 10 min indicated that the structural evolution of starch in rice kernels was time- and temperature-dependent.
33092921	0	53	from	evolution	20:28	arg1	rice					43:46	rice	43:46	rice	43:46	Effect of structure evolution of starch in rice on the textural formation of cooked rice.
33092921	1	54	theme	rice	121:124	arg1	kernels					126:132	rice kernels	121:132	rice kernels	121:132	The content and composition of rice kernels are closely related to the textural properties of cooked rice.
33092921	4	55	theme	leached	553:559	arg1	solids					561:566	leached solids	553:566	leached solids	553:566	The molecular weight (Mw) of starch and protein in leached solids increased with the leaching at 70-100 °C.
33547961	4	0	theme	experimental	735:746	arg1	designs					748:754	Three experimental designs	729:754	Three experimental designs	729:754	Three experimental designs were used to optimize the concentrations of each variable to obtain higher concentration of isomaltulose.
33547961	1	1	theme	alternative	164:174	arg1	Isomaltulose					145:156	Isomaltulose	145:156	Isomaltulose	145:156	Isomaltulose is an alternative sugar obtained from sucrose using some bacteria producing glycosyltransferase.
33547961	1	1	theme	alternative	164:174	arg1	sugar					176:180	an alternative sugar	161:180	an alternative sugar obtained from sucrose using some bacteria producing glycosyltransferase	161:252	Isomaltulose is an alternative sugar obtained from sucrose using some bacteria producing glycosyltransferase.
33547961	4	2	used	used	761:764	arg2	designs					748:754	Three experimental designs	729:754	Three experimental designs	729:754	Three experimental designs were used to optimize the concentrations of each variable to obtain higher concentration of isomaltulose.
33547961	6	3	theme	sucrose	1230:1236	arg1	conversion					1216:1225	the conversion	1212:1225	the conversion of sucrose into isomaltulose	1212:1254	As a result, the transglutaminase application as a cross-linking agent improved the immobilization of Serratia plymuthica cells and the conversion of sucrose into isomaltulose.
33547961	6	3	theme	sucrose	1230:1236	arg1	result					1085:1090	a result	1083:1090	a result	1083:1090	As a result, the transglutaminase application as a cross-linking agent improved the immobilization of Serratia plymuthica cells and the conversion of sucrose into isomaltulose.
33547961	6	3	theme	sucrose	1230:1236	arg1	immobilization					1164:1177	the immobilization	1160:1177	the immobilization of Serratia plymuthica cells	1160:1206	As a result, the transglutaminase application as a cross-linking agent improved the immobilization of Serratia plymuthica cells and the conversion of sucrose into isomaltulose.
33547961	4	4	theme	higher	824:829	arg1	concentration					831:843	higher concentration	824:843	higher concentration of isomaltulose	824:859	Three experimental designs were used to optimize the concentrations of each variable to obtain higher concentration of isomaltulose.
33547961	2	5	theme	Serratia	320:327	arg1	plymuthica					329:338	Serratia plymuthica	320:338	Serratia plymuthica	320:338	This work aimed to optimize conditions for the immobilization of Serratia plymuthica through ionic gelation and cross-linking by transglutaminase using the sequential experimental strategy for the conversion of sucrose into isomaltulose.
33547961	6	6	theme	transglutaminase	1097:1112	arg1	application					1114:1124	the transglutaminase application	1093:1124	the transglutaminase application as a cross-linking agent	1093:1149	As a result, the transglutaminase application as a cross-linking agent improved the immobilization of Serratia plymuthica cells and the conversion of sucrose into isomaltulose.
33547961	3	7	theme	calcium	593:599	arg1	chloride					601:608	calcium chloride	593:608	calcium chloride	593:608	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride) was studied, as well as the interactions between them on the matrix composition for the S. plymuthica immobilization.
33547961	0	8	theme	sucrose	118:124	arg1	conversion					104:113	the conversion	100:113	the conversion of sucrose into isomaltulose	100:142	Immobilization of Serratia plymuthica by ionic gelation and cross-linking with transglutaminase for the conversion of sucrose into isomaltulose.
33547961	5	9	theme	sucrose	883:889	arg1	conversion					869:878	A high conversion	862:878	A high conversion of sucrose into isomaltulose (71.04%)	862:916	A high conversion of sucrose into isomaltulose (71.04%) was obtained by the cells immobilized in a matrix composed of alginate (1.7%), CaCl2 (0.25 mol/L), gelatin (0.5%), transglutaminase (3.5%) and cell mass (33.5%).
33547961	0	10	with	cross-linking	60:72	arg1	transglutaminase					79:94	transglutaminase	79:94	transglutaminase	79:94	Immobilization of Serratia plymuthica by ionic gelation and cross-linking with transglutaminase for the conversion of sucrose into isomaltulose.
33547961	3	11	theme	transglutaminase	571:586	arg1	concentrations					523:536	concentrations	523:536	concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride	523:608	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride) was studied, as well as the interactions between them on the matrix composition for the S. plymuthica immobilization.
33547961	3	12	from	interactions	639:650	arg1	composition					679:689	the matrix composition	668:689	the matrix composition for the S. plymuthica immobilization	668:726	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride) was studied, as well as the interactions between them on the matrix composition for the S. plymuthica immobilization.
33547961	6	13	theme	cross-linking	1131:1143	arg1	agent					1145:1149	a cross-linking agent	1129:1149	a cross-linking agent	1129:1149	As a result, the transglutaminase application as a cross-linking agent improved the immobilization of Serratia plymuthica cells and the conversion of sucrose into isomaltulose.
33547961	5	14	theme	cell	1061:1064	arg1	mass					1066:1069	cell mass	1061:1069	cell mass (33.5%)	1061:1077	A high conversion of sucrose into isomaltulose (71.04%) was obtained by the cells immobilized in a matrix composed of alginate (1.7%), CaCl2 (0.25 mol/L), gelatin (0.5%), transglutaminase (3.5%) and cell mass (33.5%).
33547961	5	14	theme	cell	1061:1064	arg1	%					1076:1076	33.5%	1072:1076	33.5%	1072:1076	A high conversion of sucrose into isomaltulose (71.04%) was obtained by the cells immobilized in a matrix composed of alginate (1.7%), CaCl2 (0.25 mol/L), gelatin (0.5%), transglutaminase (3.5%) and cell mass (33.5%).
33547961	6	15	theme	cells	1202:1206	arg1	conversion					1216:1225	the conversion	1212:1225	the conversion of sucrose into isomaltulose	1212:1254	As a result, the transglutaminase application as a cross-linking agent improved the immobilization of Serratia plymuthica cells and the conversion of sucrose into isomaltulose.
33547961	6	15	theme	cells	1202:1206	arg1	result					1085:1090	a result	1083:1090	a result	1083:1090	As a result, the transglutaminase application as a cross-linking agent improved the immobilization of Serratia plymuthica cells and the conversion of sucrose into isomaltulose.
33547961	6	15	theme	cells	1202:1206	arg1	immobilization					1164:1177	the immobilization	1160:1177	the immobilization of Serratia plymuthica cells	1160:1206	As a result, the transglutaminase application as a cross-linking agent improved the immobilization of Serratia plymuthica cells and the conversion of sucrose into isomaltulose.
33547961	6	16	theme	plymuthica	1191:1200	arg1	cells					1202:1206	Serratia plymuthica cells	1182:1206	Serratia plymuthica cells	1182:1206	As a result, the transglutaminase application as a cross-linking agent improved the immobilization of Serratia plymuthica cells and the conversion of sucrose into isomaltulose.
33547961	6	17	theme	Serratia	1182:1189	arg1	plymuthica					1191:1200	Serratia plymuthica	1182:1200	Serratia plymuthica cells	1182:1206	As a result, the transglutaminase application as a cross-linking agent improved the immobilization of Serratia plymuthica cells and the conversion of sucrose into isomaltulose.
33547961	2	18	theme	ionic	348:352	arg1	gelation					354:361	ionic gelation	348:361	ionic gelation	348:361	This work aimed to optimize conditions for the immobilization of Serratia plymuthica through ionic gelation and cross-linking by transglutaminase using the sequential experimental strategy for the conversion of sucrose into isomaltulose.
33547961	4	19	theme	variable	805:812	arg1	concentrations					782:795	the concentrations	778:795	the concentrations of each variable	778:812	Three experimental designs were used to optimize the concentrations of each variable to obtain higher concentration of isomaltulose.
33547961	0	20	theme	plymuthica	27:36	arg1	Immobilization					0:13	Immobilization	0:13	Immobilization of Serratia plymuthica by ionic gelation and cross-linking with transglutaminase for the conversion of sucrose into isomaltulose.	0:143	Immobilization of Serratia plymuthica by ionic gelation and cross-linking with transglutaminase for the conversion of sucrose into isomaltulose.
33547961	3	21	theme	chloride	601:608	arg1	concentrations					523:536	concentrations	523:536	concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride	523:608	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride) was studied, as well as the interactions between them on the matrix composition for the S. plymuthica immobilization.
33547961	0	22	theme	Serratia	18:25	arg1	plymuthica					27:36	Serratia plymuthica	18:36	Serratia plymuthica	18:36	Immobilization of Serratia plymuthica by ionic gelation and cross-linking with transglutaminase for the conversion of sucrose into isomaltulose.
33547961	3	23	theme	matrix	672:677	arg1	composition					679:689	the matrix composition	668:689	the matrix composition for the S. plymuthica immobilization	668:726	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride) was studied, as well as the interactions between them on the matrix composition for the S. plymuthica immobilization.
33547961	2	24	theme	plymuthica	329:338	arg1	immobilization					302:315	the immobilization	298:315	the immobilization of Serratia plymuthica through ionic gelation and cross-linking by transglutaminase using the sequential experimental strategy for the conversion of sucrose into isomaltulose	298:490	This work aimed to optimize conditions for the immobilization of Serratia plymuthica through ionic gelation and cross-linking by transglutaminase using the sequential experimental strategy for the conversion of sucrose into isomaltulose.
33547961	3	25	theme	gelatin	562:568	arg1	concentrations					523:536	concentrations	523:536	concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride	523:608	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride) was studied, as well as the interactions between them on the matrix composition for the S. plymuthica immobilization.
33547961	0	26	theme	ionic	41:45	arg1	gelation					47:54	ionic gelation	41:54	ionic gelation	41:54	Immobilization of Serratia plymuthica by ionic gelation and cross-linking with transglutaminase for the conversion of sucrose into isomaltulose.
33547961	2	27	theme	sucrose	466:472	arg1	conversion					452:461	the conversion	448:461	the conversion of sucrose into isomaltulose	448:490	This work aimed to optimize conditions for the immobilization of Serratia plymuthica through ionic gelation and cross-linking by transglutaminase using the sequential experimental strategy for the conversion of sucrose into isomaltulose.
33547961	5	28	theme	high	864:867	arg1	conversion					869:878	A high conversion	862:878	A high conversion of sucrose into isomaltulose (71.04%)	862:916	A high conversion of sucrose into isomaltulose (71.04%) was obtained by the cells immobilized in a matrix composed of alginate (1.7%), CaCl2 (0.25 mol/L), gelatin (0.5%), transglutaminase (3.5%) and cell mass (33.5%).
33547961	3	29	theme	variables	512:520	arg1	effect					497:502	The effect	493:502	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride)	493:609	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride) was studied, as well as the interactions between them on the matrix composition for the S. plymuthica immobilization.
33547961	3	30	theme	alginate	552:559	arg1	concentrations					523:536	concentrations	523:536	concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride	523:608	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride) was studied, as well as the interactions between them on the matrix composition for the S. plymuthica immobilization.
33547961	3	31	theme	mass	546:549	arg1	concentrations					523:536	concentrations	523:536	concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride	523:608	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride) was studied, as well as the interactions between them on the matrix composition for the S. plymuthica immobilization.
33547961	3	32	theme	S.	699:700	arg1	immobilization					713:726	the S. plymuthica immobilization	695:726	the S. plymuthica immobilization	695:726	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride) was studied, as well as the interactions between them on the matrix composition for the S. plymuthica immobilization.
33547961	3	33	theme	plymuthica	702:711	arg1	immobilization					713:726	the S. plymuthica immobilization	695:726	the S. plymuthica immobilization	695:726	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride) was studied, as well as the interactions between them on the matrix composition for the S. plymuthica immobilization.
33547961	3	34	dep	variables	512:520	arg1	concentrations					523:536	concentrations	523:536	concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride	523:608	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride) was studied, as well as the interactions between them on the matrix composition for the S. plymuthica immobilization.
33547961	3	35	theme	cell	541:544	arg1	mass					546:549	cell mass	541:549	cell mass	541:549	The effect of five variables (concentrations of cell mass, alginate, gelatin, transglutaminase, and calcium chloride) was studied, as well as the interactions between them on the matrix composition for the S. plymuthica immobilization.
33547961	4	36	theme	isomaltulose	848:859	arg1	concentration					831:843	higher concentration	824:843	higher concentration of isomaltulose	824:859	Three experimental designs were used to optimize the concentrations of each variable to obtain higher concentration of isomaltulose.
33547961	0	37	with	gelation	47:54	arg1	transglutaminase					79:94	transglutaminase	79:94	transglutaminase	79:94	Immobilization of Serratia plymuthica by ionic gelation and cross-linking with transglutaminase for the conversion of sucrose into isomaltulose.
33547961	2	38	theme	experimental	422:433	arg1	strategy					435:442	the sequential experimental strategy	407:442	the sequential experimental strategy for the conversion of sucrose into isomaltulose	407:490	This work aimed to optimize conditions for the immobilization of Serratia plymuthica through ionic gelation and cross-linking by transglutaminase using the sequential experimental strategy for the conversion of sucrose into isomaltulose.
33547961	2	39	theme	sequential	411:420	arg1	strategy					435:442	the sequential experimental strategy	407:442	the sequential experimental strategy for the conversion of sucrose into isomaltulose	407:490	This work aimed to optimize conditions for the immobilization of Serratia plymuthica through ionic gelation and cross-linking by transglutaminase using the sequential experimental strategy for the conversion of sucrose into isomaltulose.
34371039	4	0	theme	adsorption	488:497	arg1	equilibrium					499:509	the adsorption equilibrium	484:509	the adsorption equilibrium	484:509	The methylene blue (MB) adsorption by chitosan/silica nanocomposite achieved the adsorption equilibrium within 60 min.
34371039	6	1	theme	regeneration	752:763	arg1	capability					765:774	high regeneration capability	747:774	high regeneration capability	747:774	Chitosan/silica composite displayed high regeneration capability and recovery of MB up to five cycles without the loss of the adsorption efficiency.
34371039	6	2	theme	adsorption	837:846	arg1	efficiency					848:857	the adsorption efficiency	833:857	the adsorption efficiency	833:857	Chitosan/silica composite displayed high regeneration capability and recovery of MB up to five cycles without the loss of the adsorption efficiency.
34371039	7	3	theme	chitosan/silica	902:916	arg1	material					950:957	an appropriate material	935:957	an appropriate material for the adsorption of organic pollutants from wastewater	935:1014	The current study showed that as-prepared chitosan/silica nanocomposite is an appropriate material for the adsorption of organic pollutants from wastewater.
34371039	7	3	theme	chitosan/silica	902:916	arg1	nanocomposite					918:930	as-prepared chitosan/silica nanocomposite	890:930	as-prepared chitosan/silica nanocomposite	890:930	The current study showed that as-prepared chitosan/silica nanocomposite is an appropriate material for the adsorption of organic pollutants from wastewater.
34371039	6	4	theme	efficiency	848:857	arg1	loss					825:828	the loss	821:828	the loss of the adsorption efficiency	821:857	Chitosan/silica composite displayed high regeneration capability and recovery of MB up to five cycles without the loss of the adsorption efficiency.
34371039	5	5	theme	847.5 mg/g	671:680	arg1	capacity					659:666	a maximum adsorption capacity	638:666	a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution	638:708	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	5	6	theme	Langmuir	607:614	arg1	adsorption					616:625	Langmuir adsorption	607:625	the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution	603:708	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	7	7	from	adsorption	967:976	arg1	wastewater					1005:1014	wastewater	1005:1014	wastewater	1005:1014	The current study showed that as-prepared chitosan/silica nanocomposite is an appropriate material for the adsorption of organic pollutants from wastewater.
34371039	7	8	from	wastewater	1005:1014	arg1	adsorption					967:976	the adsorption	963:976	the adsorption of organic pollutants from wastewater	963:1014	The current study showed that as-prepared chitosan/silica nanocomposite is an appropriate material for the adsorption of organic pollutants from wastewater.
34371039	7	8	from	wastewater	1005:1014	arg1	pollutants					989:998	organic pollutants	981:998	organic pollutants from wastewater	981:1014	The current study showed that as-prepared chitosan/silica nanocomposite is an appropriate material for the adsorption of organic pollutants from wastewater.
34371039	5	9	theme	adsorption	616:625	arg1	model					627:631	the Langmuir adsorption model	603:631	the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution	603:708	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	6	10	theme	high	747:750	arg1	capability					765:774	high regeneration capability	747:774	high regeneration capability	747:774	Chitosan/silica composite displayed high regeneration capability and recovery of MB up to five cycles without the loss of the adsorption efficiency.
34371039	3	11	theme	silica	317:322	arg1	precursor					324:332	silica precursor	317:332	silica precursor	317:332	The results showed that silica precursor interacts with chitosan and deposits as regular spherical nanoparticles.
34371039	4	12	theme	chitosan/silica	445:459	arg1	nanocomposite					461:473	chitosan/silica nanocomposite	445:473	chitosan/silica nanocomposite	445:473	The methylene blue (MB) adsorption by chitosan/silica nanocomposite achieved the adsorption equilibrium within 60 min.
34371039	7	13	theme	as-prepared	890:900	arg1	material					950:957	an appropriate material	935:957	an appropriate material for the adsorption of organic pollutants from wastewater	935:1014	The current study showed that as-prepared chitosan/silica nanocomposite is an appropriate material for the adsorption of organic pollutants from wastewater.
34371039	7	13	theme	as-prepared	890:900	arg1	nanocomposite					918:930	as-prepared chitosan/silica nanocomposite	890:930	as-prepared chitosan/silica nanocomposite	890:930	The current study showed that as-prepared chitosan/silica nanocomposite is an appropriate material for the adsorption of organic pollutants from wastewater.
34371039	5	14	theme	pseudo-second-order	565:583	arg1	model					593:597	the pseudo-second-order kinetic model	561:597	the pseudo-second-order kinetic model	561:597	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	1	15	theme	sol-gel	172:178	arg1	process					180:186	sol-gel process	172:186	sol-gel process	172:186	A new adsorbent from chitosan and anionic silica was prepared by ionic interaction followed by sol-gel process.
34371039	6	16	dep	cycles	806:811	arg1	up					795:796	up	795:796	up	795:796	Chitosan/silica composite displayed high regeneration capability and recovery of MB up to five cycles without the loss of the adsorption efficiency.
34371039	5	17	theme	maximum	640:646	arg1	capacity					659:666	a maximum adsorption capacity	638:666	a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution	638:708	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	5	18	theme	kinetic	585:591	arg1	model					593:597	the pseudo-second-order kinetic model	561:597	the pseudo-second-order kinetic model	561:597	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	6	19	theme	Chitosan/silica	711:725	arg1	composite					727:735	Chitosan/silica composite	711:735	Chitosan/silica composite	711:735	Chitosan/silica composite displayed high regeneration capability and recovery of MB up to five cycles without the loss of the adsorption efficiency.
34371039	0	20	theme	Ionic	0:4	arg1	chitosan/silica					6:20	Ionic chitosan/silica	0:20	Ionic chitosan/silica	0:20	Ionic chitosan/silica nanocomposite as efficient adsorbent for organic dyes.
34371039	5	21	with	model	593:597	arg1	capacity					659:666	a maximum adsorption capacity	638:666	a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution	638:708	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	5	22	theme	adsorption	648:657	arg1	capacity					659:666	a maximum adsorption capacity	638:666	a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution	638:708	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	1	23	from	silica	119:124	arg1	adsorbent					83:91	adsorbent	83:91	adsorbent	83:91	A new adsorbent from chitosan and anionic silica was prepared by ionic interaction followed by sol-gel process.
34371039	7	24	theme	current	864:870	arg1	study					872:876	The current study	860:876	The current study	860:876	The current study showed that as-prepared chitosan/silica nanocomposite is an appropriate material for the adsorption of organic pollutants from wastewater.
34371039	2	25	dep	techniques	247:256	arg1	TEM					288:290	TEM	288:290	TEM	288:290	The obtained nanocomposite was characterized by different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM.
34371039	2	25	dep	techniques	247:256	arg1	techniques					247:256	different techniques	237:256	different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM	237:290	The obtained nanocomposite was characterized by different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM.
34371039	2	25	dep	techniques	247:256	arg1	SEM/EDX					270:276	SEM/EDX	270:276	SEM/EDX	270:276	The obtained nanocomposite was characterized by different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM.
34371039	2	25	dep	techniques	247:256	arg1	TGA					279:281	TGA	279:281	TGA	279:281	The obtained nanocomposite was characterized by different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM.
34371039	2	25	dep	techniques	247:256	arg1	FTIR					259:262	FTIR	259:262	FTIR	259:262	The obtained nanocomposite was characterized by different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM.
34371039	2	25	dep	techniques	247:256	arg1	XRD					265:267	XRD	265:267	XRD	265:267	The obtained nanocomposite was characterized by different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM.
34371039	2	26	theme	different	237:245	arg1	TEM					288:290	TEM	288:290	TEM	288:290	The obtained nanocomposite was characterized by different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM.
34371039	2	26	theme	different	237:245	arg1	techniques					247:256	different techniques	237:256	different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM	237:290	The obtained nanocomposite was characterized by different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM.
34371039	2	26	theme	different	237:245	arg1	SEM/EDX					270:276	SEM/EDX	270:276	SEM/EDX	270:276	The obtained nanocomposite was characterized by different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM.
34371039	2	26	theme	different	237:245	arg1	TGA					279:281	TGA	279:281	TGA	279:281	The obtained nanocomposite was characterized by different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM.
34371039	2	26	theme	different	237:245	arg1	FTIR					259:262	FTIR	259:262	FTIR	259:262	The obtained nanocomposite was characterized by different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM.
34371039	2	26	theme	different	237:245	arg1	XRD					265:267	XRD	265:267	XRD	265:267	The obtained nanocomposite was characterized by different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM.
34371039	0	27	theme	organic	63:69	arg1	dyes					71:74	organic dyes	63:74	organic dyes	63:74	Ionic chitosan/silica nanocomposite as efficient adsorbent for organic dyes.
34371039	5	28	with	model	627:631	arg1	capacity					659:666	a maximum adsorption capacity	638:666	a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution	638:708	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	5	29	theme	slight	685:690	arg1	solution					701:708	slight alkaline solution	685:708	slight alkaline solution	685:708	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	1	30	theme	anionic	111:117	arg1	silica					119:124	anionic silica	111:124	anionic silica	111:124	A new adsorbent from chitosan and anionic silica was prepared by ionic interaction followed by sol-gel process.
34371039	3	31	theme	spherical	382:390	arg1	nanoparticles					392:404	regular spherical nanoparticles	374:404	regular spherical nanoparticles	374:404	The results showed that silica precursor interacts with chitosan and deposits as regular spherical nanoparticles.
34371039	5	32	from	capacity	659:666	arg1	solution					701:708	slight alkaline solution	685:708	slight alkaline solution	685:708	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	5	33	theme	alkaline	692:699	arg1	solution					701:708	slight alkaline solution	685:708	slight alkaline solution	685:708	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	6	34	theme	MB	792:793	arg1	recovery					780:787	recovery	780:787	recovery	780:787	Chitosan/silica composite displayed high regeneration capability and recovery of MB up to five cycles without the loss of the adsorption efficiency.
34371039	6	34	theme	MB	792:793	arg1	capability					765:774	high regeneration capability	747:774	high regeneration capability	747:774	Chitosan/silica composite displayed high regeneration capability and recovery of MB up to five cycles without the loss of the adsorption efficiency.
34371039	1	35	from	chitosan	98:105	arg1	adsorbent					83:91	adsorbent	83:91	adsorbent	83:91	A new adsorbent from chitosan and anionic silica was prepared by ionic interaction followed by sol-gel process.
34371039	7	36	theme	organic	981:987	arg1	pollutants					989:998	organic pollutants	981:998	organic pollutants from wastewater	981:1014	The current study showed that as-prepared chitosan/silica nanocomposite is an appropriate material for the adsorption of organic pollutants from wastewater.
34371039	5	37	from	solution	701:708	arg1	847.5 mg/g					671:680	847.5 mg/g	671:680	847.5 mg/g at slight alkaline solution	671:708	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	5	37	from	solution	701:708	arg1	capacity					659:666	a maximum adsorption capacity	638:666	a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution	638:708	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	2	38	theme	obtained	193:200	arg1	nanocomposite					202:214	The obtained nanocomposite	189:214	The obtained nanocomposite	189:214	The obtained nanocomposite was characterized by different techniques: FTIR, XRD, SEM/EDX, TGA, and TEM.
34371039	7	39	theme	pollutants	989:998	arg1	adsorption					967:976	the adsorption	963:976	the adsorption of organic pollutants from wastewater	963:1014	The current study showed that as-prepared chitosan/silica nanocomposite is an appropriate material for the adsorption of organic pollutants from wastewater.
34371039	7	40	theme	appropriate	938:948	arg1	material					950:957	an appropriate material	935:957	an appropriate material for the adsorption of organic pollutants from wastewater	935:1014	The current study showed that as-prepared chitosan/silica nanocomposite is an appropriate material for the adsorption of organic pollutants from wastewater.
34371039	7	40	theme	appropriate	938:948	arg1	nanocomposite					918:930	as-prepared chitosan/silica nanocomposite	890:930	as-prepared chitosan/silica nanocomposite	890:930	The current study showed that as-prepared chitosan/silica nanocomposite is an appropriate material for the adsorption of organic pollutants from wastewater.
34371039	4	41	dep	blue	421:424	arg1	MB					427:428	MB	427:428	MB	427:428	The methylene blue (MB) adsorption by chitosan/silica nanocomposite achieved the adsorption equilibrium within 60 min.
34371039	4	42	theme	blue	421:424	arg1	adsorption					431:440	The methylene blue (MB) adsorption	407:440	The methylene blue (MB) adsorption by chitosan/silica nanocomposite	407:473	The methylene blue (MB) adsorption by chitosan/silica nanocomposite achieved the adsorption equilibrium within 60 min.
34371039	3	43	theme	regular	374:380	arg1	nanoparticles					392:404	regular spherical nanoparticles	374:404	regular spherical nanoparticles	374:404	The results showed that silica precursor interacts with chitosan and deposits as regular spherical nanoparticles.
34371039	5	44	theme	adsorption	530:539	arg1	method					541:546	The adsorption method	526:546	The adsorption method	526:546	The adsorption method is fitted to the pseudo-second-order kinetic model and the Langmuir adsorption model with a maximum adsorption capacity of 847.5 mg/g at slight alkaline solution.
34371039	1	45	theme	ionic	142:146	arg1	interaction					148:158	ionic interaction	142:158	ionic interaction followed by sol-gel process	142:186	A new adsorbent from chitosan and anionic silica was prepared by ionic interaction followed by sol-gel process.
33832227	4	0	theme	medium	958:963	arg1	pH					936:937	the pH	932:937	the pH of the surrounding medium	932:963	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	3	1	theme	electron	742:749	arg1	microscopy					751:760	scanning electron microscopy	733:760	scanning electron microscopy	733:760	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	5	2	theme	bioactive	1083:1091	arg1	release					1099:1105	pH-responsive bioactive agent release	1069:1105	pH-responsive bioactive agent release	1069:1105	Our film warrants further development and optimization as a carrier to mediate pH-responsive bioactive agent release.
33832227	1	3	theme	film	173:176	arg1	Development					142:152	Development	142:152	Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery	142:229	Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery has a high practical value for food and pharmaceutical applications.
33832227	1	4	theme	pharmaceutical	271:284	arg1	applications					286:297	food and pharmaceutical applications	262:297	food and pharmaceutical applications	262:297	Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery has a high practical value for food and pharmaceutical applications.
33832227	4	5	theme	surrounding	946:956	arg1	medium					958:963	the surrounding medium	942:963	the surrounding medium	942:963	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	4	6	from	film	881:884	arg1	percentage					819:828	the percentage	815:828	the percentage of cumulative release of DOX from the agent-loaded film	815:884	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	4	6	from	film	881:884	arg1	release					844:850	cumulative release	833:850	cumulative release of DOX from the agent-loaded film	833:884	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	4	7	theme	agent-loaded	868:879	arg1	film					881:884	the agent-loaded film	864:884	the agent-loaded film	864:884	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	2	8	theme	casting	364:370	arg1	approach					372:379	the solution casting approach	351:379	the solution casting approach	351:379	In this study, we generate a composite film, using the solution casting approach, from carboxymethyl chitosan (CMC) and magnetite nanoparticles (MNPs).
33832227	0	9	theme	pH-responsive	103:115	arg1	release					133:139	pH-responsive bioactive agent release	103:139	pH-responsive bioactive agent release	103:139	Development of a composite film fabricated from carboxymethyl chitosan and magnetite nanoparticles for pH-responsive bioactive agent release.
33832227	4	10	theme	model	802:806	arg1	agent					808:812	a model agent	800:812	a model agent	800:812	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	4	11	theme	doxorubicin	779:789	arg1	use					772:774	the use	768:774	the use of doxorubicin (DOX) as a model agent	768:812	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	0	12	theme	agent	127:131	arg1	release					133:139	pH-responsive bioactive agent release	103:139	pH-responsive bioactive agent release	103:139	Development of a composite film fabricated from carboxymethyl chitosan and magnetite nanoparticles for pH-responsive bioactive agent release.
33832227	4	13	theme	DOX	855:857	arg1	release					844:850	cumulative release	833:850	cumulative release of DOX from the agent-loaded film	833:884	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	3	14	theme	film	514:517	arg1	structures					456:465	The structures	452:465	The structures	452:465	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	14	theme	film	514:517	arg1	properties					471:480	properties	471:480	properties	471:480	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	4	15	dep	5.0	985:987	arg1	to					982:983	to	982:983	to	982:983	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	1	16	theme	stimuli-responsive	187:204	arg1	delivery					222:229	stimuli-responsive bioactive agent delivery	187:229	stimuli-responsive bioactive agent delivery	187:229	Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery has a high practical value for food and pharmaceutical applications.
33832227	0	17	theme	bioactive	117:125	arg1	release					133:139	pH-responsive bioactive agent release	103:139	pH-responsive bioactive agent release	103:139	Development of a composite film fabricated from carboxymethyl chitosan and magnetite nanoparticles for pH-responsive bioactive agent release.
33832227	5	18	theme	pH-responsive	1069:1081	arg1	release					1099:1105	pH-responsive bioactive agent release	1069:1105	pH-responsive bioactive agent release	1069:1105	Our film warrants further development and optimization as a carrier to mediate pH-responsive bioactive agent release.
33832227	1	19	theme	bioactive	206:214	arg1	delivery					222:229	stimuli-responsive bioactive agent delivery	187:229	stimuli-responsive bioactive agent delivery	187:229	Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery has a high practical value for food and pharmaceutical applications.
33832227	3	20	theme	generated	504:512	arg1	film					514:517	the generated film	500:517	the generated film	500:517	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	21	theme	characterization	554:569	arg1	calorimetry					656:666	differential scanning calorimetry	634:666	differential scanning calorimetry	634:666	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	21	theme	characterization	554:569	arg1	analysis					687:694	thermogravimetric analysis	669:694	thermogravimetric analysis	669:694	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	21	theme	characterization	554:569	arg1	spectroscopy					620:631	Fourier-transform infrared spectroscopy	593:631	Fourier-transform infrared spectroscopy	593:631	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	21	theme	characterization	554:569	arg1	techniques					571:580	various characterization techniques	546:580	various characterization techniques	546:580	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	21	theme	characterization	554:569	arg1	microscopy					751:760	scanning electron microscopy	733:760	scanning electron microscopy	733:760	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	21	theme	characterization	554:569	arg1	spectroscopy					715:726	x-ray diffraction spectroscopy	697:726	x-ray diffraction spectroscopy	697:726	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	1	22	theme	agent	216:220	arg1	delivery					222:229	stimuli-responsive bioactive agent delivery	187:229	stimuli-responsive bioactive agent delivery	187:229	Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery has a high practical value for food and pharmaceutical applications.
33832227	3	23	theme	x-ray	697:701	arg1	spectroscopy					715:726	x-ray diffraction spectroscopy	697:726	x-ray diffraction spectroscopy	697:726	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	2	24	theme	composite	329:337	arg1	film					339:342	a composite film	327:342	a composite film	327:342	In this study, we generate a composite film, using the solution casting approach, from carboxymethyl chitosan (CMC) and magnetite nanoparticles (MNPs).
33832227	2	25	theme	carboxymethyl	387:399	arg1	CMC					411:413	CMC	411:413	CMC	411:413	In this study, we generate a composite film, using the solution casting approach, from carboxymethyl chitosan (CMC) and magnetite nanoparticles (MNPs).
33832227	2	25	theme	carboxymethyl	387:399	arg1	chitosan					401:408	carboxymethyl chitosan	387:408	carboxymethyl chitosan (CMC)	387:414	In this study, we generate a composite film, using the solution casting approach, from carboxymethyl chitosan (CMC) and magnetite nanoparticles (MNPs).
33832227	0	26	theme	composite	17:25	arg1	film					27:30	a composite film	15:30	a composite film fabricated from carboxymethyl chitosan and magnetite	15:83	Development of a composite film fabricated from carboxymethyl chitosan and magnetite nanoparticles for pH-responsive bioactive agent release.
33832227	4	27	theme	%	918:918	arg1	%					925:925	55% to 62%	916:925	55% to 62%	916:925	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	3	28	theme	thermogravimetric	669:685	arg1	analysis					687:694	thermogravimetric analysis	669:694	thermogravimetric analysis	669:694	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	29	theme	various	546:552	arg1	calorimetry					656:666	differential scanning calorimetry	634:666	differential scanning calorimetry	634:666	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	29	theme	various	546:552	arg1	analysis					687:694	thermogravimetric analysis	669:694	thermogravimetric analysis	669:694	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	29	theme	various	546:552	arg1	spectroscopy					620:631	Fourier-transform infrared spectroscopy	593:631	Fourier-transform infrared spectroscopy	593:631	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	29	theme	various	546:552	arg1	techniques					571:580	various characterization techniques	546:580	various characterization techniques	546:580	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	29	theme	various	546:552	arg1	microscopy					751:760	scanning electron microscopy	733:760	scanning electron microscopy	733:760	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	29	theme	various	546:552	arg1	spectroscopy					715:726	x-ray diffraction spectroscopy	697:726	x-ray diffraction spectroscopy	697:726	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	2	30	theme	magnetite	420:428	arg1	MNPs					445:448	MNPs	445:448	MNPs	445:448	In this study, we generate a composite film, using the solution casting approach, from carboxymethyl chitosan (CMC) and magnetite nanoparticles (MNPs).
33832227	2	30	theme	magnetite	420:428	arg1	nanoparticles					430:442	magnetite nanoparticles	420:442	magnetite nanoparticles (MNPs)	420:449	In this study, we generate a composite film, using the solution casting approach, from carboxymethyl chitosan (CMC) and magnetite nanoparticles (MNPs).
33832227	3	31	theme	Fourier-transform	593:609	arg1	spectroscopy					620:631	Fourier-transform infrared spectroscopy	593:631	Fourier-transform infrared spectroscopy	593:631	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	1	32	theme	high	237:240	arg1	value					252:256	a high practical value	235:256	a high practical value for food and pharmaceutical applications	235:297	Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery has a high practical value for food and pharmaceutical applications.
33832227	0	33	theme	film	27:30	arg1	Development					0:10	Development	0:10	Development of a composite film fabricated from carboxymethyl chitosan and magnetite	0:83	Development of a composite film fabricated from carboxymethyl chitosan and magnetite nanoparticles for pH-responsive bioactive agent release.
33832227	4	34	dep	%	925:925	arg1	to					920:921	to	920:921	to	920:921	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	3	35	theme	infrared	611:618	arg1	spectroscopy					620:631	Fourier-transform infrared spectroscopy	593:631	Fourier-transform infrared spectroscopy	593:631	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	2	36	from	chitosan	401:408	arg1	film					339:342	a composite film	327:342	a composite film	327:342	In this study, we generate a composite film, using the solution casting approach, from carboxymethyl chitosan (CMC) and magnetite nanoparticles (MNPs).
33832227	1	37	theme	practical	242:250	arg1	value					252:256	a high practical value	235:256	a high practical value for food and pharmaceutical applications	235:297	Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery has a high practical value for food and pharmaceutical applications.
33832227	0	38	theme	carboxymethyl	48:60	arg1	chitosan					62:69	carboxymethyl chitosan	48:69	carboxymethyl chitosan	48:69	Development of a composite film fabricated from carboxymethyl chitosan and magnetite nanoparticles for pH-responsive bioactive agent release.
33832227	4	39	theme	release	844:850	arg1	percentage					819:828	the percentage	815:828	the percentage of cumulative release of DOX from the agent-loaded film	815:884	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	2	40	theme	solution	355:362	arg1	approach					372:379	the solution casting approach	351:379	the solution casting approach	351:379	In this study, we generate a composite film, using the solution casting approach, from carboxymethyl chitosan (CMC) and magnetite nanoparticles (MNPs).
33832227	5	41	theme	agent	1093:1097	arg1	release					1099:1105	pH-responsive bioactive agent release	1069:1105	pH-responsive bioactive agent release	1069:1105	Our film warrants further development and optimization as a carrier to mediate pH-responsive bioactive agent release.
33832227	3	42	theme	diffraction	703:713	arg1	spectroscopy					715:726	x-ray diffraction spectroscopy	697:726	x-ray diffraction spectroscopy	697:726	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	4	43	theme	cumulative	833:842	arg1	release					844:850	cumulative release	833:850	cumulative release of DOX from the agent-loaded film	833:884	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	3	44	theme	MNPs	490:493	arg1	structures					456:465	The structures	452:465	The structures	452:465	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	44	theme	MNPs	490:493	arg1	properties					471:480	properties	471:480	properties	471:480	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	5	45	theme	further	1008:1014	arg1	development					1016:1026	further development	1008:1026	further development	1008:1026	Our film warrants further development and optimization as a carrier to mediate pH-responsive bioactive agent release.
33832227	5	45	theme	further	1008:1014	arg1	optimization					1032:1043	optimization	1032:1043	optimization	1032:1043	Our film warrants further development and optimization as a carrier to mediate pH-responsive bioactive agent release.
33832227	5	45	theme	further	1008:1014	arg1	carrier					1050:1056	a carrier	1048:1056	a carrier to mediate pH-responsive bioactive agent release	1048:1105	Our film warrants further development and optimization as a carrier to mediate pH-responsive bioactive agent release.
33832227	3	46	theme	differential	634:645	arg1	calorimetry					656:666	differential scanning calorimetry	634:666	differential scanning calorimetry	634:666	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	4	47	from	percentage	819:828	arg1	film					881:884	the agent-loaded film	864:884	the agent-loaded film	864:884	With the use of doxorubicin (DOX) as a model agent, the percentage of cumulative release of DOX from the agent-loaded film is found to be increased from 55% to 62% when the pH of the surrounding medium changes from 7.4 to 5.0.
33832227	3	48	theme	scanning	647:654	arg1	calorimetry					656:666	differential scanning calorimetry	634:666	differential scanning calorimetry	634:666	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	49	theme	CMC	485:487	arg1	structures					456:465	The structures	452:465	The structures	452:465	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	3	49	theme	CMC	485:487	arg1	properties					471:480	properties	471:480	properties	471:480	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	1	50	contain	has	231:233	arg1	Development					142:152	Development	142:152	Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery	142:229	Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery has a high practical value for food and pharmaceutical applications.
33832227	1	50	contain	has	231:233	arg2	value					252:256	a high practical value	235:256	a high practical value for food and pharmaceutical applications	235:297	Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery has a high practical value for food and pharmaceutical applications.
33832227	1	51	theme	food	262:265	arg1	applications					286:297	food and pharmaceutical applications	262:297	food and pharmaceutical applications	262:297	Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery has a high practical value for food and pharmaceutical applications.
33832227	3	52	theme	scanning	733:740	arg1	microscopy					751:760	scanning electron microscopy	733:760	scanning electron microscopy	733:760	The structures and properties of CMC, MNPs, and the generated film are characterized by using various characterization techniques, including Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, x-ray diffraction spectroscopy, and scanning electron microscopy.
33832227	2	53	from	nanoparticles	430:442	arg1	film					339:342	a composite film	327:342	a composite film	327:342	In this study, we generate a composite film, using the solution casting approach, from carboxymethyl chitosan (CMC) and magnetite nanoparticles (MNPs).
33832227	1	54	theme	biocompatible	159:171	arg1	film					173:176	a biocompatible film	157:176	a biocompatible film enabling stimuli-responsive bioactive agent delivery	157:229	Development of a biocompatible film enabling stimuli-responsive bioactive agent delivery has a high practical value for food and pharmaceutical applications.
33861936	0	0	theme	Fat	74:76	arg1	Mice					100:103	High Fat Diet-Induced C57BL/6N Mice	69:103	High Fat Diet-Induced C57BL/6N Mice	69:103	Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice.
33861936	6	1	from	activation	790:799	arg1	tissues					862:868	colon and spleen tissues	845:868	colon and spleen tissues	845:868	Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues.
33861936	7	2	theme	mineral	884:890	arg1	compositions					892:903	the mineral compositions	880:903	the mineral compositions of sea salts	880:916	However, the mineral compositions of sea salts were not simply associated with anticancer effects in AOM/DSS+HFD induced mice.
33861936	4	3	theme	sea	651:653	arg1	salts					655:659	The differently prepared sea salts	626:659	The differently prepared sea salts	626:659	The differently prepared sea salts also ameliorated liver injury.
33861936	6	4	theme	spleen	855:860	arg1	tissues					862:868	colon and spleen tissues	845:868	colon and spleen tissues	845:868	Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues.
33861936	0	5	theme	High	69:72	arg1	Mice					100:103	High Fat Diet-Induced C57BL/6N Mice	69:103	High Fat Diet-Induced C57BL/6N Mice	69:103	Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice.
33861936	7	6	from	effects	961:967	arg1	mice					992:995	AOM/DSS+HFD induced mice	972:995	AOM/DSS+HFD induced mice	972:995	However, the mineral compositions of sea salts were not simply associated with anticancer effects in AOM/DSS+HFD induced mice.
33861936	6	7	from	tissues	862:868	arg1	activation					790:799	activation	790:799	activation of natural killer cell (CD56) expression in colon and spleen tissues	790:868	Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues.
33861936	0	8	theme	C57BL/6N	91:98	arg1	Mice					100:103	High Fat Diet-Induced C57BL/6N Mice	69:103	High Fat Diet-Induced C57BL/6N Mice	69:103	Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice.
33861936	1	9	theme	C57BL/6N	282:289	arg1	mice					291:294	C57BL/6N mice	282:294	C57BL/6N mice	282:294	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	4	10	theme	prepared	642:649	arg1	salts					655:659	The differently prepared sea salts	626:659	The differently prepared sea salts	626:659	The differently prepared sea salts also ameliorated liver injury.
33861936	1	11	with	obesity	271:277	arg1	cancer					260:265	high fat diet (HFD)-induced colon cancer	226:265	high fat diet (HFD)-induced colon cancer	226:265	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	6	12	theme	colon	845:849	arg1	tissues					862:868	colon and spleen tissues	845:868	colon and spleen tissues	845:868	Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues.
33861936	0	13	theme	Diet-Induced	78:89	arg1	Mice					100:103	High Fat Diet-Induced C57BL/6N Mice	69:103	High Fat Diet-Induced C57BL/6N Mice	69:103	Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice.
33861936	3	14	theme	cancer	602:607	arg1	ratio					556:560	colon length/weight ratio	536:560	colon length/weight ratio	536:560	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	3	14	theme	cancer	602:607	arg1	number					569:574	tumor number	563:574	tumor number	563:574	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	3	14	theme	cancer	602:607	arg1	progression					581:591	progression	581:591	progression of colon cancer in colon tissue	581:623	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	6	15	theme	natural	804:810	arg1	CD56					825:828	CD56	825:828	CD56	825:828	Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues.
33861936	6	15	theme	natural	804:810	arg1	cell					819:822	natural killer cell	804:822	natural killer cell (CD56) expression in colon and spleen tissues	804:868	Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues.
33861936	1	16	theme	high	226:229	arg1	HFD					241:243	HFD	241:243	HFD	241:243	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	1	16	theme	high	226:229	arg1	diet					235:238	high fat diet	226:238	high fat diet (HFD)	226:244	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	0	17	from	Cancer	46:51	arg1	AOM/DSS					56:62	AOM/DSS	56:62	AOM/DSS with High Fat Diet-Induced C57BL/6N Mice	56:103	Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice.
33861936	5	18	theme	mineral	709:715	arg1	composition					717:727	the mineral composition	705:727	the mineral composition of each salt	705:740	In addition, the mineral composition of each salt was different.
33861936	5	18	theme	mineral	709:715	arg1	different					746:754	different	746:754	different	746:754	In addition, the mineral composition of each salt was different.
33861936	0	19	with	AOM/DSS	56:62	arg1	Mice					100:103	High Fat Diet-Induced C57BL/6N Mice	69:103	High Fat Diet-Induced C57BL/6N Mice	69:103	Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice.
33861936	8	20	theme	salts	1045:1049	arg1	effects					1030:1036	the anticolorectal cancer effects	1004:1036	the anticolorectal cancer effects of sea salts	1004:1049	Thus, the anticolorectal cancer effects of sea salts may be mediated by different factors, which remain to be identified.
33861936	3	21	from	progression	581:591	arg1	tissue					618:623	colon tissue	612:623	colon tissue	612:623	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	3	22	from	number	569:574	arg1	tissue					618:623	colon tissue	612:623	colon tissue	612:623	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	1	23	from	effects	121:127	arg1	sulfate					207:213	azoxymethane (AOM)/dextran sodium sulfate	173:213	azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer	173:265	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	1	23	from	effects	121:127	arg1	obesity					271:277	obesity	271:277	obesity in C57BL/6N mice	271:294	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	1	23	from	effects	121:127	arg1	DSS					216:218	DSS	216:218	DSS	216:218	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	2	24	theme	sea	370:372	arg1	GS					380:381	GS	380:381	GS	380:381	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	2	24	theme	sea	370:372	arg1	salt					374:377	generally manufactured sea salt	347:377	generally manufactured sea salt (GS)	347:382	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	1	25	theme	sea	160:162	arg1	salts					164:168	Shinan (Shinan-South Korea) sea salts	132:168	Shinan (Shinan-South Korea) sea salts	132:168	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	0	26	theme	Sea	7:9	arg1	Intake					16:21	Shinan Sea Salt Intake	0:21	Shinan Sea Salt Intake	0:21	Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice.
33861936	3	27	theme	colon	596:600	arg1	cancer					602:607	colon cancer	596:607	colon cancer	596:607	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	2	28	dep	salt	374:377	arg1	manufactured					443:454	manufactured	443:454	manufactured with only new seawater (NS)	443:482	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	2	28	dep	salt	374:377	arg1	manufactured					395:406	manufactured	395:406	manufactured after filtering seawater (FS)	395:436	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	6	29	theme	expression	831:840	arg1	activation					790:799	activation	790:799	activation of natural killer cell (CD56) expression in colon and spleen tissues	790:868	Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues.
33861936	5	30	from	addition	695:702	arg1	composition					717:727	the mineral composition	705:727	the mineral composition of each salt	705:740	In addition, the mineral composition of each salt was different.
33861936	5	30	from	addition	695:702	arg1	different					746:754	different	746:754	different	746:754	In addition, the mineral composition of each salt was different.
33861936	1	31	theme	salts	164:168	arg1	effects					121:127	The anticancer effects	106:127	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice	106:294	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	0	32	theme	Shinan	0:5	arg1	Intake					16:21	Shinan Sea Salt Intake	0:21	Shinan Sea Salt Intake	0:21	Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice.
33861936	1	33	theme	fat	231:233	arg1	HFD					241:243	HFD	241:243	HFD	241:243	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	1	33	theme	fat	231:233	arg1	diet					235:238	high fat diet	226:238	high fat diet (HFD)	226:244	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	7	34	theme	induced	984:990	arg1	mice					992:995	AOM/DSS+HFD induced mice	972:995	AOM/DSS+HFD induced mice	972:995	However, the mineral compositions of sea salts were not simply associated with anticancer effects in AOM/DSS+HFD induced mice.
33861936	2	35	theme	manufactured	357:368	arg1	GS					380:381	GS	380:381	GS	380:381	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	2	35	theme	manufactured	357:368	arg1	salt					374:377	generally manufactured sea salt	347:377	generally manufactured sea salt (GS)	347:382	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	3	36	theme	salt	489:492	arg1	intake					494:499	Sea salt intake	485:499	Sea salt intake	485:499	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	1	37	theme	azoxymethane	173:184	arg1	sulfate					207:213	azoxymethane (AOM)/dextran sodium sulfate	173:213	azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer	173:265	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	1	37	theme	azoxymethane	173:184	arg1	DSS					216:218	DSS	216:218	DSS	216:218	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	0	38	theme	Salt	11:14	arg1	Intake					16:21	Shinan Sea Salt Intake	0:21	Shinan Sea Salt Intake	0:21	Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice.
33861936	3	39	theme	colon	612:616	arg1	tissue					618:623	colon tissue	612:623	colon tissue	612:623	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	8	40	theme	anticolorectal	1008:1021	arg1	effects					1030:1036	the anticolorectal cancer effects	1004:1036	the anticolorectal cancer effects of sea salts	1004:1049	Thus, the anticolorectal cancer effects of sea salts may be mediated by different factors, which remain to be identified.
33861936	2	41	theme	salt	341:344	arg1	types					328:332	three types	322:332	three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS)	322:482	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	0	42	theme	Colorectal	35:44	arg1	Cancer					46:51	Colorectal Cancer	35:51	Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice	35:103	Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice.
33861936	6	43	from	expression	831:840	arg1	tissues					862:868	colon and spleen tissues	845:868	colon and spleen tissues	845:868	Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues.
33861936	3	44	theme	colon	536:540	arg1	ratio					556:560	colon length/weight ratio	536:560	colon length/weight ratio	536:560	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	2	45	theme	sea	337:339	arg1	salt					341:344	sea salt	337:344	sea salt	337:344	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	6	46	theme	cell	819:822	arg1	expression					831:840	natural killer cell (CD56) expression	804:840	natural killer cell (CD56) expression in colon and spleen tissues	804:868	Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues.
33861936	7	47	theme	salts	912:916	arg1	compositions					892:903	the mineral compositions	880:903	the mineral compositions of sea salts	880:916	However, the mineral compositions of sea salts were not simply associated with anticancer effects in AOM/DSS+HFD induced mice.
33861936	3	48	theme	Sea	485:487	arg1	intake					494:499	Sea salt intake	485:499	Sea salt intake	485:499	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	8	49	theme	cancer	1023:1028	arg1	effects					1030:1036	the anticolorectal cancer effects	1004:1036	the anticolorectal cancer effects of sea salts	1004:1049	Thus, the anticolorectal cancer effects of sea salts may be mediated by different factors, which remain to be identified.
33861936	7	50	theme	sea	908:910	arg1	salts					912:916	sea salts	908:916	sea salts	908:916	However, the mineral compositions of sea salts were not simply associated with anticancer effects in AOM/DSS+HFD induced mice.
33861936	1	51	theme	-induced	245:252	arg1	cancer					260:265	high fat diet (HFD)-induced colon cancer	226:265	high fat diet (HFD)-induced colon cancer	226:265	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	1	52	from	sulfate	207:213	arg1	mice					291:294	C57BL/6N mice	282:294	C57BL/6N mice	282:294	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	1	53	from	obesity	271:277	arg1	mice					291:294	C57BL/6N mice	282:294	C57BL/6N mice	282:294	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	1	54	theme	colon	254:258	arg1	cancer					260:265	high fat diet (HFD)-induced colon cancer	226:265	high fat diet (HFD)-induced colon cancer	226:265	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	7	55	theme	anticancer	950:959	arg1	effects					961:967	anticancer effects	950:967	anticancer effects in AOM/DSS+HFD induced mice	950:995	However, the mineral compositions of sea salts were not simply associated with anticancer effects in AOM/DSS+HFD induced mice.
33861936	1	56	theme	anticancer	110:119	arg1	effects					121:127	The anticancer effects	106:127	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice	106:294	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	2	57	theme	new	466:468	arg1	NS					480:481	NS	480:481	NS	480:481	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	2	57	theme	new	466:468	arg1	seawater					470:477	only new seawater	461:477	only new seawater (NS)	461:482	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	3	58	theme	tumor	563:567	arg1	number					569:574	tumor number	563:574	tumor number	563:574	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	1	59	theme	/dextran	191:198	arg1	sulfate					207:213	azoxymethane (AOM)/dextran sodium sulfate	173:213	azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer	173:265	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	1	59	theme	/dextran	191:198	arg1	DSS					216:218	DSS	216:218	DSS	216:218	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	2	60	theme	only	461:464	arg1	NS					480:481	NS	480:481	NS	480:481	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	2	60	theme	only	461:464	arg1	seawater					470:477	only new seawater	461:477	only new seawater (NS)	461:482	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	3	61	theme	length/weight	542:554	arg1	ratio					556:560	colon length/weight ratio	536:560	colon length/weight ratio	536:560	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	3	62	theme	colon	511:515	arg1	length					517:522	colon length	511:522	colon length	511:522	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	1	63	with	sulfate	207:213	arg1	cancer					260:265	high fat diet (HFD)-induced colon cancer	226:265	high fat diet (HFD)-induced colon cancer	226:265	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	8	64	theme	different	1070:1078	arg1	factors					1080:1086	different factors	1070:1086	different factors	1070:1086	Thus, the anticolorectal cancer effects of sea salts may be mediated by different factors, which remain to be identified.
33861936	1	65	theme	sodium	200:205	arg1	sulfate					207:213	azoxymethane (AOM)/dextran sodium sulfate	173:213	azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer	173:265	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	1	65	theme	sodium	200:205	arg1	DSS					216:218	DSS	216:218	DSS	216:218	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	2	66	theme	filtering	414:422	arg1	FS					434:435	FS	434:435	FS	434:435	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	2	66	theme	filtering	414:422	arg1	seawater					424:431	filtering seawater	414:431	filtering seawater (FS)	414:436	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	2	67	dep	types	328:332	arg1	GS					380:381	GS	380:381	GS	380:381	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	2	67	dep	types	328:332	arg1	salt					374:377	generally manufactured sea salt	347:377	generally manufactured sea salt (GS)	347:382	We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS).
33861936	5	68	from	different	746:754	arg1	addition					695:702	addition	695:702	addition	695:702	In addition, the mineral composition of each salt was different.
33861936	1	69	theme	Shinan	132:137	arg1	salts					164:168	Shinan (Shinan-South Korea) sea salts	132:168	Shinan (Shinan-South Korea) sea salts	132:168	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.
33861936	5	70	theme	salt	737:740	arg1	composition					717:727	the mineral composition	705:727	the mineral composition of each salt	705:740	In addition, the mineral composition of each salt was different.
33861936	5	70	theme	salt	737:740	arg1	different					746:754	different	746:754	different	746:754	In addition, the mineral composition of each salt was different.
33861936	6	71	theme	sea	771:773	arg1	salts					775:779	the sea salts	767:779	the sea salts	767:779	Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues.
33861936	3	72	from	ratio	556:560	arg1	tissue					618:623	colon tissue	612:623	colon tissue	612:623	Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue.
33861936	4	73	theme	liver	678:682	arg1	injury					684:689	liver injury	678:689	liver injury	678:689	The differently prepared sea salts also ameliorated liver injury.
33861936	8	74	theme	sea	1041:1043	arg1	salts					1045:1049	sea salts	1041:1049	sea salts	1041:1049	Thus, the anticolorectal cancer effects of sea salts may be mediated by different factors, which remain to be identified.
33861936	6	75	theme	killer	812:817	arg1	CD56					825:828	CD56	825:828	CD56	825:828	Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues.
33861936	6	75	theme	killer	812:817	arg1	cell					819:822	natural killer cell	804:822	natural killer cell (CD56) expression in colon and spleen tissues	804:868	Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues.
34343910	5	0	theme	chemical	666:673	arg1	groups					683:688	chemical surface groups	666:688	chemical surface groups	666:688	Here, CDs specific molecular characteristics (core composition and chemical surface groups) have been investigated to produce a more potent enzyme inhibition.
34343910	8	1	theme	commercial	1093:1102	arg1	constant					1023:1030	low inhibition constant	1008:1030	low inhibition constant (KI = 517.7 ± 17.0 nM)	1008:1053	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	8	1	theme	commercial	1093:1102	arg1	inhibitor					1104:1112	then the commercial inhibitor	1084:1112	up 70 fold smaller then the commercial inhibitor (kojic acid)	1065:1125	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	8	1	theme	commercial	1093:1102	arg1	acid					1121:1124	kojic acid	1115:1124	kojic acid	1115:1124	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	3	2	from	scarce	438:443	arg1	literature					452:461	the literature	448:461	the literature	448:461	Moreover, reporters comprising nanoparticle inhibitory activity against enzymes are very scarce in the literature.
34343910	5	3	theme	surface	675:681	arg1	groups					683:688	chemical surface groups	666:688	chemical surface groups	666:688	Here, CDs specific molecular characteristics (core composition and chemical surface groups) have been investigated to produce a more potent enzyme inhibition.
34343910	5	4	theme	CDs	605:607	arg1	characteristics					628:642	CDs specific molecular characteristics	605:642	CDs specific molecular characteristics (core composition and chemical surface groups)	605:689	Here, CDs specific molecular characteristics (core composition and chemical surface groups) have been investigated to produce a more potent enzyme inhibition.
34343910	9	5	theme	hydrophobic	1218:1228	arg1	agglomerate					1230:1240	a hydrophobic agglomerate	1216:1240	a hydrophobic agglomerate with carboxyl groups on its surface	1216:1276	The results expose that the CDs act as a hydrophobic agglomerate with carboxyl groups on its surface, mimicking characteristics found on small molecule inhibitors (but with superior performance).
34343910	9	5	theme	hydrophobic	1218:1228	arg1	CDs					1205:1207	the CDs	1201:1207	the CDs	1201:1207	The results expose that the CDs act as a hydrophobic agglomerate with carboxyl groups on its surface, mimicking characteristics found on small molecule inhibitors (but with superior performance).
34343910	0	6	theme	cores	96:100	arg1	gathering					71:79	a gathering	69:79	a gathering of hydrophobic cores and key chemical group	69:123	Efficient tyrosinase nano-inhibitor based on carbon dots behaving as a gathering of hydrophobic cores and key chemical group.
34343910	4	7	theme	promising	514:522	arg1	candidates					524:533	promising candidates	514:533	promising candidates for efficient enzyme inhibition due to their unique properties	514:596	In this scenario, carbon nanodots (CDs) emerge as promising candidates for efficient enzyme inhibition due to their unique properties.
34343910	5	8	theme	specific	609:616	arg1	characteristics					628:642	CDs specific molecular characteristics	605:642	CDs specific molecular characteristics (core composition and chemical surface groups)	605:689	Here, CDs specific molecular characteristics (core composition and chemical surface groups) have been investigated to produce a more potent enzyme inhibition.
34343910	2	9	theme	inhibitors	293:302	arg1	applications					304:315	small inhibitors applications	287:315	small inhibitors applications	287:315	Although numerous efforts have been made to deliver efficient inhibitors, small inhibitors applications are hindered by many drawbacks.
34343910	3	10	theme	nanoparticle	380:391	arg1	activity					404:411	nanoparticle inhibitory activity	380:411	nanoparticle inhibitory activity against enzymes	380:427	Moreover, reporters comprising nanoparticle inhibitory activity against enzymes are very scarce in the literature.
34343910	10	11	theme	excellent	1408:1416	arg1	inhibitor					1458:1466	an efficient low toxic Tyr inhibitor	1431:1466	an efficient low toxic Tyr inhibitor	1431:1466	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	10	11	theme	excellent	1408:1416	arg1	potential					1418:1426	the CD excellent potential	1401:1426	the CD excellent potential	1401:1426	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	5	12	theme	molecular	618:626	arg1	characteristics					628:642	CDs specific molecular characteristics	605:642	CDs specific molecular characteristics (core composition and chemical surface groups)	605:689	Here, CDs specific molecular characteristics (core composition and chemical surface groups) have been investigated to produce a more potent enzyme inhibition.
34343910	2	13	theme	small	287:291	arg1	applications					304:315	small inhibitors applications	287:315	small inhibitors applications	287:315	Although numerous efforts have been made to deliver efficient inhibitors, small inhibitors applications are hindered by many drawbacks.
34343910	2	14	theme	many	333:336	arg1	drawbacks					338:346	many drawbacks	333:346	many drawbacks	333:346	Although numerous efforts have been made to deliver efficient inhibitors, small inhibitors applications are hindered by many drawbacks.
34343910	0	15	theme	key	106:108	arg1	group					119:123	key chemical group	106:123	key chemical group	106:123	Efficient tyrosinase nano-inhibitor based on carbon dots behaving as a gathering of hydrophobic cores and key chemical group.
34343910	10	16	theme	Tyr	1454:1456	arg1	opening					1469:1475	opening	1469:1475	opening the prospect of using these nanoparticles in the cosmetic and food industries	1469:1553	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	10	16	theme	Tyr	1454:1456	arg1	inhibitor					1458:1466	an efficient low toxic Tyr inhibitor	1431:1466	an efficient low toxic Tyr inhibitor	1431:1466	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	10	16	theme	Tyr	1454:1456	arg1	potential					1418:1426	the CD excellent potential	1401:1426	the CD excellent potential	1401:1426	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	7	17	theme	structural	948:957	arg1	alteration					959:968	slight mTyr structural alteration	936:968	slight mTyr structural alteration	936:968	The CDs revealed a high affinity to mTyr (Ka ≈ 106 M-1), mainly through hydrophobic forces and followed by slight mTyr structural alteration.
34343910	10	18	dep	opening	1469:1475	arg1	prospect					1481:1488	the prospect	1477:1488	opening the prospect of using these nanoparticles in the cosmetic and food industries	1469:1553	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	5	19	theme	core	645:648	arg1	composition					650:660	core composition	645:660	core composition	645:660	Here, CDs specific molecular characteristics (core composition and chemical surface groups) have been investigated to produce a more potent enzyme inhibition.
34343910	9	20	with	inhibitors	1329:1338	arg1	performance					1359:1369	superior performance	1350:1369	superior performance	1350:1369	The results expose that the CDs act as a hydrophobic agglomerate with carboxyl groups on its surface, mimicking characteristics found on small molecule inhibitors (but with superior performance).
34343910	7	21	theme	high	848:851	arg1	affinity					853:860	a high affinity	846:860	a high affinity to mTyr (Ka ≈ 106 M-1)	846:883	The CDs revealed a high affinity to mTyr (Ka ≈ 106 M-1), mainly through hydrophobic forces and followed by slight mTyr structural alteration.
34343910	10	22	theme	food	1539:1542	arg1	industries					1544:1553	the cosmetic and food industries	1522:1553	the cosmetic and food industries	1522:1553	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	0	23	theme	tyrosinase	10:19	arg1	nano-inhibitor					21:34	Efficient tyrosinase nano-inhibitor	0:34	Efficient tyrosinase nano-inhibitor	0:34	Efficient tyrosinase nano-inhibitor based on carbon dots behaving as a gathering of hydrophobic cores and key chemical group.
34343910	10	24	theme	low	1444:1446	arg1	opening					1469:1475	opening	1469:1475	opening the prospect of using these nanoparticles in the cosmetic and food industries	1469:1553	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	10	24	theme	low	1444:1446	arg1	inhibitor					1458:1466	an efficient low toxic Tyr inhibitor	1431:1466	an efficient low toxic Tyr inhibitor	1431:1466	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	10	24	theme	low	1444:1446	arg1	potential					1418:1426	the CD excellent potential	1401:1426	the CD excellent potential	1401:1426	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	7	25	theme	slight	936:941	arg1	alteration					959:968	slight mTyr structural alteration	936:968	slight mTyr structural alteration	936:968	The CDs revealed a high affinity to mTyr (Ka ≈ 106 M-1), mainly through hydrophobic forces and followed by slight mTyr structural alteration.
34343910	0	26	theme	Efficient	0:8	arg1	nano-inhibitor					21:34	Efficient tyrosinase nano-inhibitor	0:34	Efficient tyrosinase nano-inhibitor	0:34	Efficient tyrosinase nano-inhibitor based on carbon dots behaving as a gathering of hydrophobic cores and key chemical group.
34343910	9	27	theme	small	1314:1318	arg1	inhibitors					1329:1338	small molecule inhibitors	1314:1338	small molecule inhibitors (but with superior performance)	1314:1370	The results expose that the CDs act as a hydrophobic agglomerate with carboxyl groups on its surface, mimicking characteristics found on small molecule inhibitors (but with superior performance).
34343910	10	28	theme	efficient	1434:1442	arg1	opening					1469:1475	opening	1469:1475	opening the prospect of using these nanoparticles in the cosmetic and food industries	1469:1553	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	10	28	theme	efficient	1434:1442	arg1	inhibitor					1458:1466	an efficient low toxic Tyr inhibitor	1431:1466	an efficient low toxic Tyr inhibitor	1431:1466	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	10	28	theme	efficient	1434:1442	arg1	potential					1418:1426	the CD excellent potential	1401:1426	the CD excellent potential	1401:1426	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	8	29	theme	inhibition	1012:1021	arg1	KI = 517.7 ± 17.0 nM					1033:1052	KI = 517.7 ± 17.0 nM	1033:1052	KI = 517.7 ± 17.0 nM	1033:1052	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	8	29	theme	inhibition	1012:1021	arg1	constant					1023:1030	low inhibition constant	1008:1030	low inhibition constant (KI = 517.7 ± 17.0 nM)	1008:1053	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	8	29	theme	inhibition	1012:1021	arg1	inhibitor					1104:1112	then the commercial inhibitor	1084:1112	up 70 fold smaller then the commercial inhibitor (kojic acid)	1065:1125	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	3	30	theme	inhibitory	393:402	arg1	activity					404:411	nanoparticle inhibitory activity	380:411	nanoparticle inhibitory activity against enzymes	380:427	Moreover, reporters comprising nanoparticle inhibitory activity against enzymes are very scarce in the literature.
34343910	4	31	theme	due	567:569	arg1	inhibition					556:565	efficient enzyme inhibition	539:565	efficient enzyme inhibition due to their unique properties	539:596	In this scenario, carbon nanodots (CDs) emerge as promising candidates for efficient enzyme inhibition due to their unique properties.
34343910	0	32	theme	group	119:123	arg1	gathering					71:79	a gathering	69:79	a gathering of hydrophobic cores and key chemical group	69:123	Efficient tyrosinase nano-inhibitor based on carbon dots behaving as a gathering of hydrophobic cores and key chemical group.
34343910	8	33	theme	low	1008:1010	arg1	KI = 517.7 ± 17.0 nM					1033:1052	KI = 517.7 ± 17.0 nM	1033:1052	KI = 517.7 ± 17.0 nM	1033:1052	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	8	33	theme	low	1008:1010	arg1	constant					1023:1030	low inhibition constant	1008:1030	low inhibition constant (KI = 517.7 ± 17.0 nM)	1008:1053	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	8	33	theme	low	1008:1010	arg1	inhibitor					1104:1112	then the commercial inhibitor	1084:1112	up 70 fold smaller then the commercial inhibitor (kojic acid)	1065:1125	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	1	34	theme	enzymatic	191:199	arg1	inhibition					201:210	enzymatic inhibition	191:210	enzymatic inhibition	191:210	Small organic molecules have been extensively applied to achieve enzymatic inhibition.
34343910	4	35	theme	unique	580:585	arg1	properties					587:596	their unique properties	574:596	their unique properties	574:596	In this scenario, carbon nanodots (CDs) emerge as promising candidates for efficient enzyme inhibition due to their unique properties.
34343910	0	36	theme	chemical	110:117	arg1	group					119:123	key chemical group	106:123	key chemical group	106:123	Efficient tyrosinase nano-inhibitor based on carbon dots behaving as a gathering of hydrophobic cores and key chemical group.
34343910	0	37	theme	carbon	45:50	arg1	dots					52:55	carbon dots	45:55	carbon dots behaving as a gathering of hydrophobic cores and key chemical group	45:123	Efficient tyrosinase nano-inhibitor based on carbon dots behaving as a gathering of hydrophobic cores and key chemical group.
34343910	10	38	from	nanoparticles	1505:1517	arg1	industries					1544:1553	the cosmetic and food industries	1522:1553	the cosmetic and food industries	1522:1553	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	9	39	located	found	1305:1309	arg1	inhibitors					1329:1338	small molecule inhibitors	1314:1338	small molecule inhibitors (but with superior performance)	1314:1370	The results expose that the CDs act as a hydrophobic agglomerate with carboxyl groups on its surface, mimicking characteristics found on small molecule inhibitors (but with superior performance).
34343910	9	39	located	found	1305:1309	arg2	characteristics					1289:1303	characteristics	1289:1303	characteristics found on small molecule inhibitors (but with superior performance)	1289:1370	The results expose that the CDs act as a hydrophobic agglomerate with carboxyl groups on its surface, mimicking characteristics found on small molecule inhibitors (but with superior performance).
34343910	4	40	theme	efficient	539:547	arg1	inhibition					556:565	efficient enzyme inhibition	539:565	efficient enzyme inhibition due to their unique properties	539:596	In this scenario, carbon nanodots (CDs) emerge as promising candidates for efficient enzyme inhibition due to their unique properties.
34343910	5	41	theme	potent	732:737	arg1	inhibition					746:755	a more potent enzyme inhibition	725:755	a more potent enzyme inhibition	725:755	Here, CDs specific molecular characteristics (core composition and chemical surface groups) have been investigated to produce a more potent enzyme inhibition.
34343910	4	42	theme	carbon	482:487	arg1	CDs					499:501	CDs	499:501	CDs	499:501	In this scenario, carbon nanodots (CDs) emerge as promising candidates for efficient enzyme inhibition due to their unique properties.
34343910	4	42	theme	carbon	482:487	arg1	nanodots					489:496	carbon nanodots	482:496	carbon nanodots (CDs)	482:502	In this scenario, carbon nanodots (CDs) emerge as promising candidates for efficient enzyme inhibition due to their unique properties.
34343910	10	43	theme	toxic	1448:1452	arg1	opening					1469:1475	opening	1469:1475	opening the prospect of using these nanoparticles in the cosmetic and food industries	1469:1553	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	10	43	theme	toxic	1448:1452	arg1	inhibitor					1458:1466	an efficient low toxic Tyr inhibitor	1431:1466	an efficient low toxic Tyr inhibitor	1431:1466	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	10	43	theme	toxic	1448:1452	arg1	potential					1418:1426	the CD excellent potential	1401:1426	the CD excellent potential	1401:1426	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	5	44	theme	enzyme	739:744	arg1	inhibition					746:755	a more potent enzyme inhibition	725:755	a more potent enzyme inhibition	725:755	Here, CDs specific molecular characteristics (core composition and chemical surface groups) have been investigated to produce a more potent enzyme inhibition.
34343910	6	45	theme	enzymatic	808:816	arg1	prototype					818:826	an enzymatic prototype	805:826	an enzymatic prototype	805:826	Mushroom tyrosinase (mTyr) has been adopted as an enzymatic prototype.
34343910	6	45	theme	enzymatic	808:816	arg1	tyrosinase					767:776	Mushroom tyrosinase	758:776	Mushroom tyrosinase (mTyr)	758:783	Mushroom tyrosinase (mTyr) has been adopted as an enzymatic prototype.
34343910	9	46	theme	molecule	1320:1327	arg1	inhibitors					1329:1338	small molecule inhibitors	1314:1338	small molecule inhibitors (but with superior performance)	1314:1370	The results expose that the CDs act as a hydrophobic agglomerate with carboxyl groups on its surface, mimicking characteristics found on small molecule inhibitors (but with superior performance).
34343910	7	47	theme	mTyr	943:946	arg1	alteration					959:968	slight mTyr structural alteration	936:968	slight mTyr structural alteration	936:968	The CDs revealed a high affinity to mTyr (Ka ≈ 106 M-1), mainly through hydrophobic forces and followed by slight mTyr structural alteration.
34343910	8	48	theme	smaller	1076:1082	arg1	constant					1023:1030	low inhibition constant	1008:1030	low inhibition constant (KI = 517.7 ± 17.0 nM)	1008:1053	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	8	48	theme	smaller	1076:1082	arg1	inhibitor					1104:1112	then the commercial inhibitor	1084:1112	up 70 fold smaller then the commercial inhibitor (kojic acid)	1065:1125	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	8	48	theme	smaller	1076:1082	arg1	acid					1121:1124	kojic acid	1115:1124	kojic acid	1115:1124	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	9	49	theme	superior	1350:1357	arg1	performance					1359:1369	superior performance	1350:1369	superior performance	1350:1369	The results expose that the CDs act as a hydrophobic agglomerate with carboxyl groups on its surface, mimicking characteristics found on small molecule inhibitors (but with superior performance).
34343910	2	50	theme	numerous	222:229	arg1	efforts					231:237	numerous efforts	222:237	numerous efforts	222:237	Although numerous efforts have been made to deliver efficient inhibitors, small inhibitors applications are hindered by many drawbacks.
34343910	7	51	theme	hydrophobic	901:911	arg1	forces					913:918	hydrophobic forces	901:918	hydrophobic forces	901:918	The CDs revealed a high affinity to mTyr (Ka ≈ 106 M-1), mainly through hydrophobic forces and followed by slight mTyr structural alteration.
34343910	4	52	theme	enzyme	549:554	arg1	inhibition					556:565	efficient enzyme inhibition	539:565	efficient enzyme inhibition due to their unique properties	539:596	In this scenario, carbon nanodots (CDs) emerge as promising candidates for efficient enzyme inhibition due to their unique properties.
34343910	10	53	theme	CD	1405:1406	arg1	inhibitor					1458:1466	an efficient low toxic Tyr inhibitor	1431:1466	an efficient low toxic Tyr inhibitor	1431:1466	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	10	53	theme	CD	1405:1406	arg1	potential					1418:1426	the CD excellent potential	1401:1426	the CD excellent potential	1401:1426	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	2	54	theme	efficient	265:273	arg1	inhibitors					275:284	efficient inhibitors	265:284	efficient inhibitors	265:284	Although numerous efforts have been made to deliver efficient inhibitors, small inhibitors applications are hindered by many drawbacks.
34343910	5	55	dep	characteristics	628:642	arg1	composition					650:660	core composition	645:660	core composition	645:660	Here, CDs specific molecular characteristics (core composition and chemical surface groups) have been investigated to produce a more potent enzyme inhibition.
34343910	5	55	dep	characteristics	628:642	arg1	groups					683:688	chemical surface groups	666:688	chemical surface groups	666:688	Here, CDs specific molecular characteristics (core composition and chemical surface groups) have been investigated to produce a more potent enzyme inhibition.
34343910	8	56	theme	starch	1135:1140	arg1	nanoparticles					1142:1154	the starch nanoparticles	1131:1154	the starch nanoparticles previously reported	1131:1174	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	9	57	theme	carboxyl	1247:1254	arg1	groups					1256:1261	carboxyl groups	1247:1261	carboxyl groups on its surface	1247:1276	The results expose that the CDs act as a hydrophobic agglomerate with carboxyl groups on its surface, mimicking characteristics found on small molecule inhibitors (but with superior performance).
34343910	6	58	theme	Mushroom	758:765	arg1	prototype					818:826	an enzymatic prototype	805:826	an enzymatic prototype	805:826	Mushroom tyrosinase (mTyr) has been adopted as an enzymatic prototype.
34343910	6	58	theme	Mushroom	758:765	arg1	mTyr					779:782	mTyr	779:782	mTyr	779:782	Mushroom tyrosinase (mTyr) has been adopted as an enzymatic prototype.
34343910	6	58	theme	Mushroom	758:765	arg1	tyrosinase					767:776	Mushroom tyrosinase	758:776	Mushroom tyrosinase (mTyr)	758:783	Mushroom tyrosinase (mTyr) has been adopted as an enzymatic prototype.
34343910	1	59	theme	Small	126:130	arg1	molecules					140:148	Small organic molecules	126:148	Small organic molecules	126:148	Small organic molecules have been extensively applied to achieve enzymatic inhibition.
34343910	9	60	with	agglomerate	1230:1240	arg1	groups					1256:1261	carboxyl groups	1247:1261	carboxyl groups on its surface	1247:1276	The results expose that the CDs act as a hydrophobic agglomerate with carboxyl groups on its surface, mimicking characteristics found on small molecule inhibitors (but with superior performance).
34343910	10	61	theme	cosmetic	1526:1533	arg1	industries					1544:1553	the cosmetic and food industries	1522:1553	the cosmetic and food industries	1522:1553	All these results highlight the CD excellent potential as an efficient low toxic Tyr inhibitor, opening the prospect of using these nanoparticles in the cosmetic and food industries.
34343910	3	62	from	literature	452:461	arg1	scarce					438:443	scarce	438:443	scarce	438:443	Moreover, reporters comprising nanoparticle inhibitory activity against enzymes are very scarce in the literature.
34343910	1	63	theme	organic	132:138	arg1	molecules					140:148	Small organic molecules	126:148	Small organic molecules	126:148	Small organic molecules have been extensively applied to achieve enzymatic inhibition.
34343910	8	64	theme	kojic	1115:1119	arg1	inhibitor					1104:1112	then the commercial inhibitor	1084:1112	up 70 fold smaller then the commercial inhibitor (kojic acid)	1065:1125	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	8	64	theme	kojic	1115:1119	arg1	acid					1121:1124	kojic acid	1115:1124	kojic acid	1115:1124	CDs competitively inhibit mTyr, with low inhibition constant (KI = 517.7 ± 17.0 nM), which is up 70 fold smaller then the commercial inhibitor (kojic acid) and the starch nanoparticles previously reported.
34343910	9	65	from	groups	1256:1261	arg1	surface					1270:1276	its surface	1266:1276	its surface	1266:1276	The results expose that the CDs act as a hydrophobic agglomerate with carboxyl groups on its surface, mimicking characteristics found on small molecule inhibitors (but with superior performance).
34343910	0	66	theme	hydrophobic	84:94	arg1	cores					96:100	hydrophobic cores	84:100	hydrophobic cores	84:100	Efficient tyrosinase nano-inhibitor based on carbon dots behaving as a gathering of hydrophobic cores and key chemical group.
34201769	2	0	theme	HA	479:480	arg1	adhesiveness					421:432	the gel adhesiveness	413:432	the gel adhesiveness of Gel	413:439	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	2	0	theme	HA	479:480	arg1	strength					467:474	the better mechanical strength	445:474	the better mechanical strength of HA	445:480	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	7	1	theme	porous	1399:1404	arg1	structures					1406:1415	more disorganized, stiffer, and less porous structures	1362:1415	more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions	1362:1478	The progressive presence of HAMA gave rise to scaffolds with more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions.
34201769	9	2	theme	physical	1659:1666	arg1	properties					1668:1677	the hydrogels´ physical properties	1644:1677	the hydrogels´ physical properties to look for the most optimal characteristics required for the intended tissue engineering application	1644:1779	Hence, the suitable choice of polymeric composition allows to regulate the hydrogels´ physical properties to look for the most optimal characteristics required for the intended tissue engineering application.
34201769	6	3	theme	GelMA/HAMA	1061:1070	arg1	hydrogels					1072:1080	Hybrid GelMA/HAMA hydrogels	1054:1080	Hybrid GelMA/HAMA hydrogels	1054:1080	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	7	4	theme	hydrogel	1458:1465	arg1	compositions					1467:1478	the hydrogel compositions	1454:1478	the hydrogel compositions	1454:1478	The progressive presence of HAMA gave rise to scaffolds with more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions.
34201769	9	5	theme	composition	1613:1623	arg1	choice					1593:1598	the suitable choice	1580:1598	the suitable choice of polymeric composition	1580:1623	Hence, the suitable choice of polymeric composition allows to regulate the hydrogels´ physical properties to look for the most optimal characteristics required for the intended tissue engineering application.
34201769	6	6	theme	GelMA	1199:1203	arg1	concentrations					1205:1218	similar GelMA concentrations	1191:1218	similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix	1191:1298	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	9	7	theme	engineering	1757:1767	arg1	application					1769:1779	the intended tissue engineering application	1737:1779	the intended tissue engineering application	1737:1779	Hence, the suitable choice of polymeric composition allows to regulate the hydrogels´ physical properties to look for the most optimal characteristics required for the intended tissue engineering application.
34201769	5	8	theme	Methacrylation	901:914	arg1	degrees					916:922	Methacrylation degrees	901:922	Methacrylation degrees of ca. 40% and 11% for GelMA and HAMA	901:960	Methacrylation degrees of ca. 40% and 11% for GelMA and HAMA, respectively, were obtained, which allows to improve the hydrogels' mechanical properties.
34201769	6	9	theme	polymeric	1283:1291	arg1	matrix					1293:1298	the polymeric matrix	1279:1298	the polymeric matrix	1279:1298	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	2	10	theme	tissues	263:269	arg1	matrix					243:248	the extracellular matrix	225:248	the extracellular matrix of different tissues	225:269	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	6	11	theme	similar	1191:1197	arg1	concentrations					1205:1218	similar GelMA concentrations	1191:1218	similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix	1191:1298	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	4	12	theme	HA	760:761	arg1	hydrogels					727:735	pure and hybrid hydrogels	711:735	hydrogels	727:735	In this work, pure and hybrid hydrogels of methacroyl-modified HA (HAMA) and Gel (GelMA) were prepared by UV photopolymerization and an extensive characterization was done to elucidate such correlations.
34201769	8	13	theme	collagenase	1545:1555	arg1	biodegradation					1557:1570	collagenase biodegradation	1545:1570	collagenase biodegradation	1545:1570	HAMA also made hybrid hydrogels more swellable and resistant to collagenase biodegradation.
34201769	5	14	theme	%	933:933	arg1	degrees					916:922	Methacrylation degrees	901:922	Methacrylation degrees of ca. 40% and 11% for GelMA and HAMA	901:960	Methacrylation degrees of ca. 40% and 11% for GelMA and HAMA, respectively, were obtained, which allows to improve the hydrogels' mechanical properties.
34201769	7	15	theme	HAMA	1329:1332	arg1	presence					1317:1324	The progressive presence	1301:1324	The progressive presence of HAMA	1301:1332	The progressive presence of HAMA gave rise to scaffolds with more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions.
34201769	9	16	theme	optimal	1700:1706	arg1	characteristics					1708:1722	the most optimal characteristics	1691:1722	the most optimal characteristics required for the intended tissue engineering application	1691:1779	Hence, the suitable choice of polymeric composition allows to regulate the hydrogels´ physical properties to look for the most optimal characteristics required for the intended tissue engineering application.
34201769	6	17	theme	elastic	1101:1107	arg1	modulus					1109:1115	elastic modulus	1101:1115	elastic modulus up to ca. 30 kPa	1101:1132	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	7	18	theme	progressive	1305:1315	arg1	presence					1317:1324	The progressive presence	1301:1324	The progressive presence of HAMA	1301:1332	The progressive presence of HAMA gave rise to scaffolds with more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions.
34201769	3	19	theme	previous	514:521	arg1	studies					523:529	previous studies	514:529	previous studies conducted so far	514:546	However, despite previous studies conducted so far, the relationship between composition and scaffold structure and physico-chemical properties has not been completely and systematically established.
34201769	6	20	theme	GelMA	1177:1181	arg1	ones					1183:1186	pure GelMA ones	1172:1186	pure GelMA ones	1172:1186	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	1	21	theme	Systematic	85:94	arg1	Characterization					96:111	Systematic Characterization	85:111	Systematic Characterization	85:111	Preparation and Systematic Characterization for Prospective Tissue Engineering Applications.
34201769	6	22	theme	Hybrid	1054:1059	arg1	hydrogels					1072:1080	Hybrid GelMA/HAMA hydrogels	1054:1080	Hybrid GelMA/HAMA hydrogels	1054:1080	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	2	23	theme	biopolymer	393:402	arg1	characteristics					369:383	the favorable characteristics	355:383	the favorable characteristics of each biopolymer	355:402	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	7	24	theme	disorganized	1367:1378	arg1	structures					1406:1415	more disorganized, stiffer, and less porous structures	1362:1415	more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions	1362:1478	The progressive presence of HAMA gave rise to scaffolds with more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions.
34201769	6	25	theme	pure	1172:1175	arg1	ones					1183:1186	pure GelMA ones	1172:1186	pure GelMA ones	1172:1186	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	4	26	theme	methacroyl-modified	740:758	arg1	HA					760:761	methacroyl-modified HA	740:761	methacroyl-modified HA (HAMA)	740:768	In this work, pure and hybrid hydrogels of methacroyl-modified HA (HAMA) and Gel (GelMA) were prepared by UV photopolymerization and an extensive characterization was done to elucidate such correlations.
34201769	4	26	theme	methacroyl-modified	740:758	arg1	HAMA					764:767	HAMA	764:767	HAMA	764:767	In this work, pure and hybrid hydrogels of methacroyl-modified HA (HAMA) and Gel (GelMA) were prepared by UV photopolymerization and an extensive characterization was done to elucidate such correlations.
34201769	7	27	theme	stiffer	1381:1387	arg1	structures					1406:1415	more disorganized, stiffer, and less porous structures	1362:1415	more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions	1362:1478	The progressive presence of HAMA gave rise to scaffolds with more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions.
34201769	2	28	theme	Gel	437:439	arg1	adhesiveness					421:432	the gel adhesiveness	413:432	the gel adhesiveness of Gel	413:439	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	2	28	theme	Gel	437:439	arg1	strength					467:474	the better mechanical strength	445:474	the better mechanical strength of HA	445:480	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	4	29	theme	extensive	833:841	arg1	characterization					843:858	an extensive characterization	830:858	an extensive characterization	830:858	In this work, pure and hybrid hydrogels of methacroyl-modified HA (HAMA) and Gel (GelMA) were prepared by UV photopolymerization and an extensive characterization was done to elucidate such correlations.
34201769	7	30	theme	mass	1446:1449	arg1	increase					1434:1441	the net increase	1426:1441	the net increase of mass in the hydrogel compositions	1426:1478	The progressive presence of HAMA gave rise to scaffolds with more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions.
34201769	6	31	theme	GelMA	1263:1267	arg1	chains					1269:1274	GelMA chains	1263:1274	GelMA chains	1263:1274	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	6	32	dep	porous	1139:1144	arg1	%					1155:1155	up to 91%	1147:1155	up to 91%	1147:1155	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	1	33	theme	Prospective	117:127	arg1	Applications					148:159	Prospective Tissue Engineering Applications	117:159	Prospective Tissue Engineering Applications	117:159	Preparation and Systematic Characterization for Prospective Tissue Engineering Applications.
34201769	2	34	theme	gel	417:419	arg1	adhesiveness					421:432	the gel adhesiveness	413:432	the gel adhesiveness of Gel	413:439	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	9	35	theme	intended	1741:1748	arg1	application					1769:1779	the intended tissue engineering application	1737:1779	the intended tissue engineering application	1737:1779	Hence, the suitable choice of polymeric composition allows to regulate the hydrogels´ physical properties to look for the most optimal characteristics required for the intended tissue engineering application.
34201769	4	36	theme	Gel	774:776	arg1	hydrogels					727:735	pure and hybrid hydrogels	711:735	hydrogels	727:735	In this work, pure and hybrid hydrogels of methacroyl-modified HA (HAMA) and Gel (GelMA) were prepared by UV photopolymerization and an extensive characterization was done to elucidate such correlations.
34201769	9	37	theme	suitable	1584:1591	arg1	choice					1593:1598	the suitable choice	1580:1598	the suitable choice of polymeric composition	1580:1623	Hence, the suitable choice of polymeric composition allows to regulate the hydrogels´ physical properties to look for the most optimal characteristics required for the intended tissue engineering application.
34201769	1	38	theme	Tissue	129:134	arg1	Applications					148:159	Prospective Tissue Engineering Applications	117:159	Prospective Tissue Engineering Applications	117:159	Preparation and Systematic Characterization for Prospective Tissue Engineering Applications.
34201769	6	39	dep	30	1127:1128	arg1	ca.					1123:1125	ca.	1123:1125	ca.	1123:1125	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	9	40	theme	tissue	1750:1755	arg1	application					1769:1779	the intended tissue engineering application	1737:1779	the intended tissue engineering application	1737:1779	Hence, the suitable choice of polymeric composition allows to regulate the hydrogels´ physical properties to look for the most optimal characteristics required for the intended tissue engineering application.
34201769	4	41	theme	pure	711:714	arg1	hydrogels					727:735	pure and hybrid hydrogels	711:735	hydrogels	727:735	In this work, pure and hybrid hydrogels of methacroyl-modified HA (HAMA) and Gel (GelMA) were prepared by UV photopolymerization and an extensive characterization was done to elucidate such correlations.
34201769	5	42	theme	mechanical	1031:1040	arg1	properties					1042:1051	the hydrogels' mechanical properties	1016:1051	the hydrogels' mechanical properties	1016:1051	Methacrylation degrees of ca. 40% and 11% for GelMA and HAMA, respectively, were obtained, which allows to improve the hydrogels' mechanical properties.
34201769	2	43	theme	matrix	243:248	arg1	gelatin					187:193	gelatin	187:193	gelatin (Gel)	187:199	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	2	43	theme	matrix	243:248	arg1	acid					173:176	Hyaluronic acid	162:176	Hyaluronic acid (HA)	162:181	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	2	43	theme	matrix	243:248	arg1	components					211:220	major components	205:220	major components of the extracellular matrix of different tissues	205:269	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	0	44	theme	Hyaluronic	33:42	arg1	Acid					44:47	Hyaluronic Acid	33:47	Hyaluronic Acid	33:47	Hybrid Methacrylated Gelatin and Hyaluronic Acid Hydrogel Scaffolds.
34201769	2	45	theme	mechanical	456:465	arg1	strength					467:474	the better mechanical strength	445:474	the better mechanical strength of HA	445:480	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	7	46	theme	net	1430:1432	arg1	increase					1434:1441	the net increase	1426:1441	the net increase of mass in the hydrogel compositions	1426:1478	The progressive presence of HAMA gave rise to scaffolds with more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions.
34201769	2	47	theme	extracellular	229:241	arg1	matrix					243:248	the extracellular matrix	225:248	the extracellular matrix of different tissues	225:269	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	2	48	theme	better	449:454	arg1	strength					467:474	the better mechanical strength	445:474	the better mechanical strength of HA	445:480	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	6	49	dep	91	1153:1154	arg1	to					1150:1151	to	1150:1151	to	1150:1151	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	1	50	theme	Engineering	136:146	arg1	Applications					148:159	Prospective Tissue Engineering Applications	117:159	Prospective Tissue Engineering Applications	117:159	Preparation and Systematic Characterization for Prospective Tissue Engineering Applications.
34201769	0	51	theme	Hydrogel	49:56	arg1	Scaffolds					58:66	Hydrogel Scaffolds	49:66	Hydrogel Scaffolds	49:66	Hybrid Methacrylated Gelatin and Hyaluronic Acid Hydrogel Scaffolds.
34201769	6	52	from	interaction	1234:1244	arg1	matrix					1293:1298	the polymeric matrix	1279:1298	the polymeric matrix	1279:1298	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	4	53	theme	such	882:885	arg1	correlations					887:898	such correlations	882:898	such correlations	882:898	In this work, pure and hybrid hydrogels of methacroyl-modified HA (HAMA) and Gel (GelMA) were prepared by UV photopolymerization and an extensive characterization was done to elucidate such correlations.
34201769	4	54	theme	UV	803:804	arg1	photopolymerization					806:824	UV photopolymerization	803:824	UV photopolymerization	803:824	In this work, pure and hybrid hydrogels of methacroyl-modified HA (HAMA) and Gel (GelMA) were prepared by UV photopolymerization and an extensive characterization was done to elucidate such correlations.
34201769	2	55	theme	hydrogels	334:342	arg1	construction					311:322	the construction	307:322	the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively	307:494	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	9	56	theme	polymeric	1603:1611	arg1	composition					1613:1623	polymeric composition	1603:1623	polymeric composition	1603:1623	Hence, the suitable choice of polymeric composition allows to regulate the hydrogels´ physical properties to look for the most optimal characteristics required for the intended tissue engineering application.
34201769	9	57	theme	hydrogels´	1648:1657	arg1	properties					1668:1677	the hydrogels´ physical properties	1644:1677	the hydrogels´ physical properties to look for the most optimal characteristics required for the intended tissue engineering application	1644:1779	Hence, the suitable choice of polymeric composition allows to regulate the hydrogels´ physical properties to look for the most optimal characteristics required for the intended tissue engineering application.
34201769	2	58	theme	major	205:209	arg1	gelatin					187:193	gelatin	187:193	gelatin (Gel)	187:199	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	2	58	theme	major	205:209	arg1	acid					173:176	Hyaluronic acid	162:176	Hyaluronic acid (HA)	162:181	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	2	58	theme	major	205:209	arg1	components					211:220	major components	205:220	major components of the extracellular matrix of different tissues	205:269	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	3	59	theme	physico-chemical	613:628	arg1	properties					630:639	physico-chemical properties	613:639	physico-chemical properties	613:639	However, despite previous studies conducted so far, the relationship between composition and scaffold structure and physico-chemical properties has not been completely and systematically established.
34201769	3	60	theme	scaffold	590:597	arg1	structure					599:607	scaffold structure	590:607	scaffold structure	590:607	However, despite previous studies conducted so far, the relationship between composition and scaffold structure and physico-chemical properties has not been completely and systematically established.
34201769	2	61	theme	hybrid	327:332	arg1	hydrogels					334:342	hybrid hydrogels	327:342	hybrid hydrogels	327:342	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	6	62	theme	thanks	1220:1225	arg1	concentrations					1205:1218	similar GelMA concentrations	1191:1218	similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix	1191:1298	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	0	63	dep	Gelatin	21:27	arg1	Scaffolds					58:66	Hydrogel Scaffolds	49:66	Hydrogel Scaffolds	49:66	Hybrid Methacrylated Gelatin and Hyaluronic Acid Hydrogel Scaffolds.
34201769	4	64	theme	hybrid	720:725	arg1	hydrogels					727:735	pure and hybrid hydrogels	711:735	hydrogels	727:735	In this work, pure and hybrid hydrogels of methacroyl-modified HA (HAMA) and Gel (GelMA) were prepared by UV photopolymerization and an extensive characterization was done to elucidate such correlations.
34201769	8	65	theme	hybrid	1496:1501	arg1	hydrogels					1503:1511	hybrid hydrogels	1496:1511	hybrid hydrogels	1496:1511	HAMA also made hybrid hydrogels more swellable and resistant to collagenase biodegradation.
34201769	2	66	theme	different	253:261	arg1	tissues					263:269	different tissues	253:269	different tissues	253:269	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	6	67	dep	kPa	1130:1132	arg1	up					1117:1118	up	1117:1118	up	1117:1118	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	5	68	theme	%	941:941	arg1	degrees					916:922	Methacrylation degrees	901:922	Methacrylation degrees of ca. 40% and 11% for GelMA and HAMA	901:960	Methacrylation degrees of ca. 40% and 11% for GelMA and HAMA, respectively, were obtained, which allows to improve the hydrogels' mechanical properties.
34201769	6	69	from	concentrations	1205:1218	arg1	stiffer					1087:1093	stiffer	1087:1093	stiffer	1087:1093	Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix.
34201769	7	70	with	scaffolds	1347:1355	arg1	structures					1406:1415	more disorganized, stiffer, and less porous structures	1362:1415	more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions	1362:1478	The progressive presence of HAMA gave rise to scaffolds with more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions.
34201769	2	71	theme	Hyaluronic	162:171	arg1	HA					179:180	HA	179:180	HA	179:180	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	2	71	theme	Hyaluronic	162:171	arg1	gelatin					187:193	gelatin	187:193	gelatin (Gel)	187:199	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	2	71	theme	Hyaluronic	162:171	arg1	acid					173:176	Hyaluronic acid	162:176	Hyaluronic acid (HA)	162:181	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	2	71	theme	Hyaluronic	162:171	arg1	components					211:220	major components	205:220	major components of the extracellular matrix of different tissues	205:269	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	2	72	theme	favorable	359:367	arg1	characteristics					369:383	the favorable characteristics	355:383	the favorable characteristics of each biopolymer	355:402	Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively.
34201769	7	73	from	increase	1434:1441	arg1	compositions					1467:1478	the hydrogel compositions	1454:1478	the hydrogel compositions	1454:1478	The progressive presence of HAMA gave rise to scaffolds with more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions.
34088834	3	0	theme	wear-resistant	319:332	arg1	cusp					334:337	the wear-resistant cusp	315:337	the wear-resistant cusp of the chiton radula tooth	315:364	For instance, the wear-resistant cusp of the chiton radula tooth works in concert with progressively softer microarchitectural units as the mollusk grazes on and erodes rock.
34088834	6	1	theme	nano	891:894	arg1	hydroxyphosphate					942:957	an amorphous ferric hydroxyphosphate	922:957	an amorphous ferric hydroxyphosphate that has not been observed as a biomineral	922:1000	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	6	1	theme	nano	891:894	arg1	santabarbaraite					905:919	nano disperse santabarbaraite	891:919	nano disperse santabarbaraite	891:919	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	6	1	theme	nano	891:894	arg1	phase					882:886	the inorganic phase	868:886	the inorganic phase	868:886	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	1	2	with	elements	147:154	arg1	properties					182:191	disparate mechanical properties	161:191	disparate mechanical properties	161:191	Engineering structures that bridge between elements with disparate mechanical properties are a significant challenge.
34088834	7	3	theme	stelleri	1214:1221	arg1	dentition					1223:1231	C. stelleri dentition	1211:1231	C. stelleri dentition	1211:1231	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	7	4	from	aspect	1135:1140	arg1	proximity					1112:1120	close proximity	1106:1120	close proximity	1106:1120	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	4	5	theme	flexible	563:570	arg1	membrane					579:586	the flexible radula membrane	559:586	the flexible radula membrane	559:586	Herein, we focus on the stylus that connects the ultrahard and stiff tooth head to the flexible radula membrane.
34088834	0	6	from	polyamorphism	11:23	arg1	tooth					39:43	the chiton tooth	28:43	the chiton tooth	28:43	Persistent polyamorphism in the chiton tooth: From a new biomineral to inks for additive manufacturing.
34088834	7	7	theme	ferric	1065:1070	arg1	phases					1047:1052	two persistent polyamorphic phases	1019:1052	two persistent polyamorphic phases	1019:1052	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	7	7	theme	ferric	1065:1070	arg1	phosphate					1072:1080	amorphous ferric phosphate	1055:1080	amorphous ferric phosphate	1055:1080	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	9	8	theme	specific	1572:1579	arg1	strength					1581:1588	the specific strength	1568:1588	the specific strength of the stylus	1568:1602	The use of amorphous phases that are low in iron and high in water content may be key to increasing the specific strength of the stylus.
34088834	7	9	theme	close	1106:1110	arg1	proximity					1112:1120	close proximity	1106:1120	close proximity	1106:1120	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	3	10	theme	tooth	360:364	arg1	cusp					334:337	the wear-resistant cusp	315:337	the wear-resistant cusp of the chiton radula tooth	315:364	For instance, the wear-resistant cusp of the chiton radula tooth works in concert with progressively softer microarchitectural units as the mollusk grazes on and erodes rock.
34088834	8	11	theme	hard	1451:1454	arg1	head					1462:1465	the hard tooth head	1447:1465	the hard tooth head	1447:1465	The stylus is a highly graded material in that its mineral content and mechanical properties vary by a factor of 3 to 8 over distances of a few hundred micrometers, seamlessly bridging between the soft radula and the hard tooth head.
34088834	5	12	theme	rich	646:649	arg1	chemistry					651:659	the rich chemistry	642:659	the rich chemistry of iron	642:667	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	7	13	theme	phase	1186:1190	arg1	transformations					1192:1206	phase transformations	1186:1206	phase transformations in C. stelleri dentition	1186:1231	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	10	14	theme	design	1662:1667	arg1	criteria					1669:1676	design criteria	1662:1676	design criteria for inks for additive manufacturing of highly tunable chitosan-based composites	1662:1756	Finally, we show that we can distill these insights into design criteria for inks for additive manufacturing of highly tunable chitosan-based composites.
34088834	5	15	theme	synchrotron	711:721	arg1	Mössbauer					723:731	particular synchrotron Mössbauer	700:731	particular synchrotron Mössbauer	700:731	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	6	16	theme	inorganic	872:880	arg1	santabarbaraite					905:919	nano disperse santabarbaraite	891:919	nano disperse santabarbaraite	891:919	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	6	16	theme	inorganic	872:880	arg1	phase					882:886	the inorganic phase	868:886	the inorganic phase	868:886	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	9	17	theme	amorphous	1479:1487	arg1	phases					1489:1494	amorphous phases	1479:1494	amorphous phases that are low in iron and high in water content	1479:1541	The use of amorphous phases that are low in iron and high in water content may be key to increasing the specific strength of the stylus.
34088834	8	18	theme	mechanical	1305:1314	arg1	properties					1316:1325	mechanical properties	1305:1325	mechanical properties	1305:1325	The stylus is a highly graded material in that its mineral content and mechanical properties vary by a factor of 3 to 8 over distances of a few hundred micrometers, seamlessly bridging between the soft radula and the hard tooth head.
34088834	4	19	theme	radula	572:577	arg1	membrane					579:586	the flexible radula membrane	559:586	the flexible radula membrane	559:586	Herein, we focus on the stylus that connects the ultrahard and stiff tooth head to the flexible radula membrane.
34088834	3	20	theme	chiton	346:351	arg1	tooth					360:364	the chiton radula tooth	342:364	the chiton radula tooth	342:364	For instance, the wear-resistant cusp of the chiton radula tooth works in concert with progressively softer microarchitectural units as the mollusk grazes on and erodes rock.
34088834	8	21	theme	graded	1257:1262	arg1	material					1264:1271	a highly graded material	1248:1271	a highly graded material in that its mineral content and mechanical properties vary by a factor of 3 to 8 over distances of a few hundred micrometers, seamlessly bridging between the soft radula and the hard tooth head	1248:1465	The stylus is a highly graded material in that its mineral content and mechanical properties vary by a factor of 3 to 8 over distances of a few hundred micrometers, seamlessly bridging between the soft radula and the hard tooth head.
34088834	8	21	theme	graded	1257:1262	arg1	stylus					1238:1243	The stylus	1234:1243	The stylus	1234:1243	The stylus is a highly graded material in that its mineral content and mechanical properties vary by a factor of 3 to 8 over distances of a few hundred micrometers, seamlessly bridging between the soft radula and the hard tooth head.
34088834	9	22	theme	phases	1489:1494	arg1	key					1550:1552	key	1550:1552	key	1550:1552	The use of amorphous phases that are low in iron and high in water content may be key to increasing the specific strength of the stylus.
34088834	9	22	theme	phases	1489:1494	arg1	use					1472:1474	The use	1468:1474	The use of amorphous phases that are low in iron and high in water content	1468:1541	The use of amorphous phases that are low in iron and high in water content may be key to increasing the specific strength of the stylus.
34088834	1	23	theme	disparate	161:169	arg1	properties					182:191	disparate mechanical properties	161:191	disparate mechanical properties	161:191	Engineering structures that bridge between elements with disparate mechanical properties are a significant challenge.
34088834	0	24	theme	additive	80:87	arg1	manufacturing					89:101	additive manufacturing	80:101	additive manufacturing	80:101	Persistent polyamorphism in the chiton tooth: From a new biomineral to inks for additive manufacturing.
34088834	9	25	from	content	1535:1541	arg1	high					1521:1524	high	1521:1524	high	1521:1524	The use of amorphous phases that are low in iron and high in water content may be key to increasing the specific strength of the stylus.
34088834	1	26	theme	mechanical	171:180	arg1	properties					182:191	disparate mechanical properties	161:191	disparate mechanical properties	161:191	Engineering structures that bridge between elements with disparate mechanical properties are a significant challenge.
34088834	5	27	theme	upper	785:789	arg1	stylus					791:796	the upper stylus	781:796	the upper stylus of Cryptochiton stelleri	781:821	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	5	27	theme	upper	785:789	arg1	tissue					848:853	a mineralized tissue	834:853	a mineralized tissue	834:853	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	7	28	theme	persistent	1023:1032	arg1	phases					1047:1052	two persistent polyamorphic phases	1019:1052	two persistent polyamorphic phases	1019:1052	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	7	28	theme	persistent	1023:1032	arg1	santabarbaraite					1086:1100	santabarbaraite	1086:1100	santabarbaraite	1086:1100	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	7	28	theme	persistent	1023:1032	arg1	phosphate					1072:1080	amorphous ferric phosphate	1055:1080	amorphous ferric phosphate	1055:1080	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	5	29	theme	X-ray	737:741	arg1	spectroscopy					754:765	X-ray absorption spectroscopy	737:765	X-ray absorption spectroscopy	737:765	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	5	30	theme	iron	664:667	arg1	chemistry					651:659	the rich chemistry	642:659	the rich chemistry of iron	642:667	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	0	31	theme	Persistent	0:9	arg1	polyamorphism					11:23	Persistent polyamorphism	0:23	Persistent polyamorphism in the chiton tooth: From a new biomineral to	0:69	Persistent polyamorphism in the chiton tooth: From a new biomineral to inks for additive manufacturing.
34088834	4	32	theme	tooth	545:549	arg1	head					551:554	stiff tooth head	539:554	stiff tooth head	539:554	Herein, we focus on the stylus that connects the ultrahard and stiff tooth head to the flexible radula membrane.
34088834	9	33	theme	stylus	1597:1602	arg1	strength					1581:1588	the specific strength	1568:1588	the specific strength of the stylus	1568:1602	The use of amorphous phases that are low in iron and high in water content may be key to increasing the specific strength of the stylus.
34088834	3	34	with	concert	375:381	arg1	units					428:432	progressively softer microarchitectural units	388:432	progressively softer microarchitectural units	388:432	For instance, the wear-resistant cusp of the chiton radula tooth works in concert with progressively softer microarchitectural units as the mollusk grazes on and erodes rock.
34088834	3	35	theme	mollusk	441:447	arg1	grazes					449:454	the mollusk grazes	437:454	the mollusk grazes on and erodes rock	437:473	For instance, the wear-resistant cusp of the chiton radula tooth works in concert with progressively softer microarchitectural units as the mollusk grazes on and erodes rock.
34088834	4	36	theme	stiff	539:543	arg1	head					551:554	stiff tooth head	539:554	stiff tooth head	539:554	Herein, we focus on the stylus that connects the ultrahard and stiff tooth head to the flexible radula membrane.
34088834	5	37	theme	spatial	677:683	arg1	resolution					685:694	high spatial resolution	672:694	high spatial resolution	672:694	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	5	38	theme	stelleri	814:821	arg1	stylus					791:796	the upper stylus	781:796	the upper stylus of Cryptochiton stelleri	781:821	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	5	38	theme	stelleri	814:821	arg1	tissue					848:853	a mineralized tissue	834:853	a mineralized tissue	834:853	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	5	39	theme	Cryptochiton	801:812	arg1	stelleri					814:821	Cryptochiton stelleri	801:821	Cryptochiton stelleri	801:821	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	7	40	theme	amorphous	1055:1063	arg1	phases					1047:1052	two persistent polyamorphic phases	1019:1052	two persistent polyamorphic phases	1019:1052	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	7	40	theme	amorphous	1055:1063	arg1	phosphate					1072:1080	amorphous ferric phosphate	1055:1080	amorphous ferric phosphate	1055:1080	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	9	41	from	high	1521:1524	arg1	content					1535:1541	water content	1529:1541	water content	1529:1541	The use of amorphous phases that are low in iron and high in water content may be key to increasing the specific strength of the stylus.
34088834	7	42	theme	unique	1128:1133	arg1	presence					1007:1014	The presence	1003:1014	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite	1003:1100	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	7	42	theme	unique	1128:1133	arg1	aspect					1135:1140	a unique aspect	1126:1140	a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition	1126:1231	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	1	43	theme	significant	199:209	arg1	structures					116:125	Engineering structures	104:125	Engineering structures that bridge between elements with disparate mechanical properties	104:191	Engineering structures that bridge between elements with disparate mechanical properties are a significant challenge.
34088834	1	43	theme	significant	199:209	arg1	challenge					211:219	a significant challenge	197:219	a significant challenge	197:219	Engineering structures that bridge between elements with disparate mechanical properties are a significant challenge.
34088834	7	44	theme	control	1173:1179	arg1	level					1164:1168	the level	1160:1168	the level of control over phase transformations in C. stelleri dentition	1160:1231	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	6	45	theme	ferric	935:940	arg1	hydroxyphosphate					942:957	an amorphous ferric hydroxyphosphate	922:957	an amorphous ferric hydroxyphosphate that has not been observed as a biomineral	922:1000	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	6	45	theme	ferric	935:940	arg1	santabarbaraite					905:919	nano disperse santabarbaraite	891:919	nano disperse santabarbaraite	891:919	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	6	45	theme	ferric	935:940	arg1	biomineral					991:1000	a biomineral	989:1000	a biomineral	989:1000	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	7	46	theme	polyamorphic	1034:1045	arg1	phases					1047:1052	two persistent polyamorphic phases	1019:1052	two persistent polyamorphic phases	1019:1052	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	7	46	theme	polyamorphic	1034:1045	arg1	santabarbaraite					1086:1100	santabarbaraite	1086:1100	santabarbaraite	1086:1100	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	7	46	theme	polyamorphic	1034:1045	arg1	phosphate					1072:1080	amorphous ferric phosphate	1055:1080	amorphous ferric phosphate	1055:1080	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	0	47	from	biomineral	57:66	arg1	polyamorphism					11:23	Persistent polyamorphism	0:23	Persistent polyamorphism in the chiton tooth: From a new biomineral to	0:69	Persistent polyamorphism in the chiton tooth: From a new biomineral to inks for additive manufacturing.
34088834	8	48	theme	8	1352:1352	arg1	factor					1337:1342	a factor	1335:1342	a factor of 3 to 8	1335:1352	The stylus is a highly graded material in that its mineral content and mechanical properties vary by a factor of 3 to 8 over distances of a few hundred micrometers, seamlessly bridging between the soft radula and the hard tooth head.
34088834	9	49	from	low	1505:1507	arg1	iron					1512:1515	iron	1512:1515	iron	1512:1515	The use of amorphous phases that are low in iron and high in water content may be key to increasing the specific strength of the stylus.
34088834	0	50	theme	chiton	32:37	arg1	tooth					39:43	the chiton tooth	28:43	the chiton tooth	28:43	Persistent polyamorphism in the chiton tooth: From a new biomineral to inks for additive manufacturing.
34088834	6	51	theme	amorphous	925:933	arg1	hydroxyphosphate					942:957	an amorphous ferric hydroxyphosphate	922:957	an amorphous ferric hydroxyphosphate that has not been observed as a biomineral	922:1000	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	6	51	theme	amorphous	925:933	arg1	santabarbaraite					905:919	nano disperse santabarbaraite	891:919	nano disperse santabarbaraite	891:919	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	6	51	theme	amorphous	925:933	arg1	biomineral					991:1000	a biomineral	989:1000	a biomineral	989:1000	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	7	52	theme	phases	1047:1052	arg1	presence					1007:1014	The presence	1003:1014	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite	1003:1100	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	7	52	theme	phases	1047:1052	arg1	aspect					1135:1140	a unique aspect	1126:1140	a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition	1126:1231	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	3	53	theme	erodes	463:468	arg1	rock					470:473	and erodes rock	459:473	rock	470:473	For instance, the wear-resistant cusp of the chiton radula tooth works in concert with progressively softer microarchitectural units as the mollusk grazes on and erodes rock.
34088834	3	54	theme	softer	402:407	arg1	units					428:432	progressively softer microarchitectural units	388:432	progressively softer microarchitectural units	388:432	For instance, the wear-resistant cusp of the chiton radula tooth works in concert with progressively softer microarchitectural units as the mollusk grazes on and erodes rock.
34088834	5	55	theme	particular	700:709	arg1	Mössbauer					723:731	particular synchrotron Mössbauer	700:731	particular synchrotron Mössbauer	700:731	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	7	56	theme	C.	1211:1212	arg1	dentition					1223:1231	C. stelleri dentition	1211:1231	C. stelleri dentition	1211:1231	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	10	57	theme	additive	1691:1698	arg1	manufacturing					1700:1712	additive manufacturing	1691:1712	additive manufacturing of highly tunable chitosan-based composites	1691:1756	Finally, we show that we can distill these insights into design criteria for inks for additive manufacturing of highly tunable chitosan-based composites.
34088834	3	58	theme	microarchitectural	409:426	arg1	units					428:432	progressively softer microarchitectural units	388:432	progressively softer microarchitectural units	388:432	For instance, the wear-resistant cusp of the chiton radula tooth works in concert with progressively softer microarchitectural units as the mollusk grazes on and erodes rock.
34088834	3	59	theme	radula	353:358	arg1	tooth					360:364	the chiton radula tooth	342:364	the chiton radula tooth	342:364	For instance, the wear-resistant cusp of the chiton radula tooth works in concert with progressively softer microarchitectural units as the mollusk grazes on and erodes rock.
34088834	9	60	theme	water	1529:1533	arg1	content					1535:1541	water content	1529:1541	water content	1529:1541	The use of amorphous phases that are low in iron and high in water content may be key to increasing the specific strength of the stylus.
34088834	1	61	theme	Engineering	104:114	arg1	structures					116:125	Engineering structures	104:125	Engineering structures that bridge between elements with disparate mechanical properties	104:191	Engineering structures that bridge between elements with disparate mechanical properties are a significant challenge.
34088834	1	61	theme	Engineering	104:114	arg1	challenge					211:219	a significant challenge	197:219	a significant challenge	197:219	Engineering structures that bridge between elements with disparate mechanical properties are a significant challenge.
34088834	8	62	theme	micrometers	1386:1396	arg1	distances					1359:1367	distances	1359:1367	distances of a few hundred micrometers, seamlessly bridging between the soft radula and the hard tooth head	1359:1465	The stylus is a highly graded material in that its mineral content and mechanical properties vary by a factor of 3 to 8 over distances of a few hundred micrometers, seamlessly bridging between the soft radula and the hard tooth head.
34088834	7	63	from	transformations	1192:1206	arg1	dentition					1223:1231	C. stelleri dentition	1211:1231	C. stelleri dentition	1211:1231	The presence of two persistent polyamorphic phases, amorphous ferric phosphate and santabarbaraite, in close proximity, is a unique aspect that demonstrates the level of control over phase transformations in C. stelleri dentition.
34088834	10	64	theme	composites	1747:1756	arg1	manufacturing					1700:1712	additive manufacturing	1691:1712	additive manufacturing of highly tunable chitosan-based composites	1691:1756	Finally, we show that we can distill these insights into design criteria for inks for additive manufacturing of highly tunable chitosan-based composites.
34088834	9	65	from	iron	1512:1515	arg1	low					1505:1507	low	1505:1507	low	1505:1507	The use of amorphous phases that are low in iron and high in water content may be key to increasing the specific strength of the stylus.
34088834	5	66	theme	high	672:675	arg1	resolution					685:694	high spatial resolution	672:694	high spatial resolution	672:694	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	8	67	dep	8	1352:1352	arg1	to					1349:1350	to	1349:1350	to	1349:1350	The stylus is a highly graded material in that its mineral content and mechanical properties vary by a factor of 3 to 8 over distances of a few hundred micrometers, seamlessly bridging between the soft radula and the hard tooth head.
34088834	10	68	theme	chitosan-based	1732:1745	arg1	composites					1747:1756	highly tunable chitosan-based composites	1717:1756	highly tunable chitosan-based composites	1717:1756	Finally, we show that we can distill these insights into design criteria for inks for additive manufacturing of highly tunable chitosan-based composites.
34088834	5	69	from	tissue	848:853	arg1	fact					829:832	fact	829:832	fact	829:832	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	0	70	theme	new	53:55	arg1	biomineral					57:66	a new biomineral	51:66	a new biomineral to	51:69	Persistent polyamorphism in the chiton tooth: From a new biomineral to inks for additive manufacturing.
34088834	8	71	theme	soft	1431:1434	arg1	radula					1436:1441	the soft radula	1427:1441	the soft radula	1427:1441	The stylus is a highly graded material in that its mineral content and mechanical properties vary by a factor of 3 to 8 over distances of a few hundred micrometers, seamlessly bridging between the soft radula and the hard tooth head.
34088834	2	72	theme	complex	257:263	arg1	shapes					265:270	complex shapes	257:270	complex shapes that are intricately graded	257:298	Organisms reap synergy by creating complex shapes that are intricately graded.
34088834	8	73	theme	mineral	1285:1291	arg1	content					1293:1299	its mineral content	1281:1299	its mineral content	1281:1299	The stylus is a highly graded material in that its mineral content and mechanical properties vary by a factor of 3 to 8 over distances of a few hundred micrometers, seamlessly bridging between the soft radula and the hard tooth head.
34088834	5	74	theme	mineralized	836:846	arg1	stylus					791:796	the upper stylus	781:796	the upper stylus of Cryptochiton stelleri	781:821	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	5	74	theme	mineralized	836:846	arg1	tissue					848:853	a mineralized tissue	834:853	a mineralized tissue	834:853	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	5	75	theme	absorption	743:752	arg1	spectroscopy					754:765	X-ray absorption spectroscopy	737:765	X-ray absorption spectroscopy	737:765	Using techniques that are especially suited to probe the rich chemistry of iron at high spatial resolution, in particular synchrotron Mössbauer and X-ray absorption spectroscopy, we find that the upper stylus of Cryptochiton stelleri is in fact a mineralized tissue.
34088834	6	76	theme	disperse	896:903	arg1	hydroxyphosphate					942:957	an amorphous ferric hydroxyphosphate	922:957	an amorphous ferric hydroxyphosphate that has not been observed as a biomineral	922:1000	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	6	76	theme	disperse	896:903	arg1	santabarbaraite					905:919	nano disperse santabarbaraite	891:919	nano disperse santabarbaraite	891:919	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	6	76	theme	disperse	896:903	arg1	phase					882:886	the inorganic phase	868:886	the inorganic phase	868:886	Remarkably, the inorganic phase is nano disperse santabarbaraite, an amorphous ferric hydroxyphosphate that has not been observed as a biomineral.
34088834	8	77	theme	few	1374:1376	arg1	micrometers					1386:1396	a few hundred micrometers	1372:1396	a few hundred micrometers	1372:1396	The stylus is a highly graded material in that its mineral content and mechanical properties vary by a factor of 3 to 8 over distances of a few hundred micrometers, seamlessly bridging between the soft radula and the hard tooth head.
34088834	3	78	from	grazes	449:454	arg1	rock					470:473	and erodes rock	459:473	rock	470:473	For instance, the wear-resistant cusp of the chiton radula tooth works in concert with progressively softer microarchitectural units as the mollusk grazes on and erodes rock.
34088834	10	79	theme	tunable	1724:1730	arg1	composites					1747:1756	highly tunable chitosan-based composites	1717:1756	highly tunable chitosan-based composites	1717:1756	Finally, we show that we can distill these insights into design criteria for inks for additive manufacturing of highly tunable chitosan-based composites.
34088834	8	80	theme	tooth	1456:1460	arg1	head					1462:1465	the hard tooth head	1447:1465	the hard tooth head	1447:1465	The stylus is a highly graded material in that its mineral content and mechanical properties vary by a factor of 3 to 8 over distances of a few hundred micrometers, seamlessly bridging between the soft radula and the hard tooth head.
33360750	7	0	theme	flocculation	1151:1162	arg1	potential					1164:1172	flocculation potential	1151:1172	flocculation potential	1151:1172	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	10	1	theme	salinity	1461:1468	arg1	tolerance					1470:1478	improved salinity tolerance	1452:1478	improved salinity tolerance	1452:1478	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	6	2	from	rich	936:939	arg1	proteins					959:966	proteins	959:966	proteins	959:966	EPS was found to be rich in carbohydrates, proteins and phenolic compounds.
33360750	6	2	from	rich	936:939	arg1	compounds					981:989	phenolic compounds	972:989	phenolic compounds	972:989	EPS was found to be rich in carbohydrates, proteins and phenolic compounds.
33360750	6	2	from	rich	936:939	arg1	carbohydrates					944:956	carbohydrates	944:956	carbohydrates	944:956	EPS was found to be rich in carbohydrates, proteins and phenolic compounds.
33360750	2	3	theme	saline	406:411	arg1	soil					413:416	saline soil	406:416	saline soil	406:416	Salt-tolerant Pseudomonas entomophila PE3 was isolated from saline soil and screened for plant growth promoting (PGP) traits.
33360750	10	4	from	results	1420:1426	arg1	attributes					1480:1489	growth promotion and improved salinity tolerance attributes	1431:1489	growth promotion and improved salinity tolerance attributes of inoculated sunflower plants	1431:1520	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	0	5	theme	growth	86:91	arg1	responses					114:122	growth, yield and tolerance responses	86:122	growth, yield and tolerance responses of sunflower	86:135	Pseudomonas entomophila PE3 and its exopolysaccharides as biostimulants for enhancing growth, yield and tolerance responses of sunflower under saline conditions.
33360750	10	6	with	breakthrough	1575:1586	arg1	results					1420:1426	promising results	1410:1426	promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants	1410:1520	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	7	7	theme	salt-tolerance	1037:1050	arg1	activity					1106:1113	hydroxyl scavenging activity	1086:1113	hydroxyl scavenging activity	1086:1113	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	7	7	theme	salt-tolerance	1037:1050	arg1	power					1125:1129	power	1125:1129	power	1125:1129	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	7	7	theme	salt-tolerance	1037:1050	arg1	accumulation					1183:1194	Na+ accumulation	1179:1194	Na+ accumulation	1179:1194	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	7	7	theme	salt-tolerance	1037:1050	arg1	antioxidant					1073:1083	antioxidant	1073:1083	antioxidant	1073:1083	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	7	7	theme	salt-tolerance	1037:1050	arg1	properties					1052:1061	salt-tolerance properties	1037:1061	salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability	1037:1202	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	10	8	theme	plants	1515:1520	arg1	attributes					1480:1489	growth promotion and improved salinity tolerance attributes	1431:1489	growth promotion and improved salinity tolerance attributes of inoculated sunflower plants	1431:1520	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	6	9	from	carbohydrates	944:956	arg1	rich					936:939	rich	936:939	rich	936:939	EPS was found to be rich in carbohydrates, proteins and phenolic compounds.
33360750	6	10	from	compounds	981:989	arg1	rich					936:939	rich	936:939	rich	936:939	EPS was found to be rich in carbohydrates, proteins and phenolic compounds.
33360750	4	11	theme	2	721:721	arg1	%					722:722	%	722:722	%	722:722	Maximum stimulation of PGP attributes was recorded at 2% NaCl concentration.
33360750	1	12	theme	potential	272:280	arg1	remediation					295:305	a potential eco-friendly remediation and productivity enhancement strategy	270:343	remediation	295:305	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions can be a potential eco-friendly remediation and productivity enhancement strategy.
33360750	1	12	theme	potential	272:280	arg1	Evaluation					162:171	Evaluation	162:171	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions	162:261	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions can be a potential eco-friendly remediation and productivity enhancement strategy.
33360750	0	13	theme	yield	94:98	arg1	responses					114:122	growth, yield and tolerance responses	86:122	growth, yield and tolerance responses of sunflower	86:135	Pseudomonas entomophila PE3 and its exopolysaccharides as biostimulants for enhancing growth, yield and tolerance responses of sunflower under saline conditions.
33360750	3	14	theme	gibberellic	519:529	arg1	acid					531:534	gibberellic acid	519:534	gibberellic acid (GA)	519:539	The isolate produced indole acetic acid (IAA), gibberellic acid (GA), exopolysaccharides (EPS) and siderophore along with the potential to solubilize potassium (K), zinc (Zn) and phosphorus (P).
33360750	3	14	theme	gibberellic	519:529	arg1	GA					537:538	GA	537:538	GA	537:538	The isolate produced indole acetic acid (IAA), gibberellic acid (GA), exopolysaccharides (EPS) and siderophore along with the potential to solubilize potassium (K), zinc (Zn) and phosphorus (P).
33360750	1	15	theme	eco-friendly	282:293	arg1	remediation					295:305	a potential eco-friendly remediation and productivity enhancement strategy	270:343	remediation	295:305	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions can be a potential eco-friendly remediation and productivity enhancement strategy.
33360750	1	15	theme	eco-friendly	282:293	arg1	Evaluation					162:171	Evaluation	162:171	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions	162:261	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions can be a potential eco-friendly remediation and productivity enhancement strategy.
33360750	9	16	theme	saline	1392:1397	arg1	soil					1399:1402	saline soil	1392:1402	saline soil	1392:1402	Finally, EPS based bioformulation of isolate PE3 was checked through field assay in saline soil.
33360750	2	17	attach	isolated	392:399	arg1	soil					413:416	saline soil	406:416	saline soil	406:416	Salt-tolerant Pseudomonas entomophila PE3 was isolated from saline soil and screened for plant growth promoting (PGP) traits.
33360750	2	17	attach	isolated	392:399	arg2	PE3					384:386	Salt-tolerant Pseudomonas entomophila PE3	346:386	Salt-tolerant Pseudomonas entomophila PE3	346:386	Salt-tolerant Pseudomonas entomophila PE3 was isolated from saline soil and screened for plant growth promoting (PGP) traits.
33360750	4	18	theme	attributes	694:703	arg1	stimulation					675:685	Maximum stimulation	667:685	Maximum stimulation of PGP attributes	667:703	Maximum stimulation of PGP attributes was recorded at 2% NaCl concentration.
33360750	4	19	theme	NaCl	724:727	arg1	concentration					729:741	2% NaCl concentration	721:741	2% NaCl concentration	721:741	Maximum stimulation of PGP attributes was recorded at 2% NaCl concentration.
33360750	1	20	theme	plant	176:180	arg1	growth					182:187	plant growth	176:187	plant growth promoting bacteria and the associated metabolites under saline conditions	176:261	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions can be a potential eco-friendly remediation and productivity enhancement strategy.
33360750	0	21	theme	tolerance	104:112	arg1	responses					114:122	growth, yield and tolerance responses	86:122	growth, yield and tolerance responses of sunflower	86:135	Pseudomonas entomophila PE3 and its exopolysaccharides as biostimulants for enhancing growth, yield and tolerance responses of sunflower under saline conditions.
33360750	7	22	dep	antioxidant	1073:1083	arg1	ability					1196:1202	ability	1196:1202	ability	1196:1202	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	6	23	from	proteins	959:966	arg1	rich					936:939	rich	936:939	rich	936:939	EPS was found to be rich in carbohydrates, proteins and phenolic compounds.
33360750	4	24	theme	%	722:722	arg1	concentration					729:741	2% NaCl concentration	721:741	2% NaCl concentration	721:741	Maximum stimulation of PGP attributes was recorded at 2% NaCl concentration.
33360750	1	25	theme	growth	182:187	arg1	remediation					295:305	a potential eco-friendly remediation and productivity enhancement strategy	270:343	remediation	295:305	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions can be a potential eco-friendly remediation and productivity enhancement strategy.
33360750	1	25	theme	growth	182:187	arg1	Evaluation					162:171	Evaluation	162:171	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions	162:261	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions can be a potential eco-friendly remediation and productivity enhancement strategy.
33360750	10	26	theme	improved	1452:1459	arg1	tolerance					1470:1478	improved salinity tolerance	1452:1478	improved salinity tolerance	1452:1478	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	10	27	theme	sunflower	1505:1513	arg1	plants					1515:1520	inoculated sunflower plants	1494:1520	inoculated sunflower plants	1494:1520	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	2	28	theme	Pseudomonas	360:370	arg1	PE3					384:386	Salt-tolerant Pseudomonas entomophila PE3	346:386	Salt-tolerant Pseudomonas entomophila PE3	346:386	Salt-tolerant Pseudomonas entomophila PE3 was isolated from saline soil and screened for plant growth promoting (PGP) traits.
33360750	0	29	theme	Pseudomonas	0:10	arg1	PE3					24:26	Pseudomonas entomophila PE3	0:26	Pseudomonas entomophila PE3	0:26	Pseudomonas entomophila PE3 and its exopolysaccharides as biostimulants for enhancing growth, yield and tolerance responses of sunflower under saline conditions.
33360750	2	30	theme	Salt-tolerant	346:358	arg1	PE3					384:386	Salt-tolerant Pseudomonas entomophila PE3	346:386	Salt-tolerant Pseudomonas entomophila PE3	346:386	Salt-tolerant Pseudomonas entomophila PE3 was isolated from saline soil and screened for plant growth promoting (PGP) traits.
33360750	5	31	theme	different	809:817	arg1	concentrations					824:837	different salt concentrations	809:837	different salt concentrations	809:837	To determine the role of EPS, their composition was analyzed (at different salt concentrations) and comparison was done to determine the changes upon exposure to salinity.
33360750	7	32	theme	scavenging	1095:1104	arg1	activity					1106:1113	hydroxyl scavenging activity	1086:1113	hydroxyl scavenging activity	1086:1113	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	8	33	theme	EPS	1253:1255	arg1	properties					1239:1248	the salt tolerance properties	1220:1248	the salt tolerance properties of EPS	1220:1255	Interestingly, the salt tolerance properties of EPS were enhanced upon exposure to salinity (2% NaCl).
33360750	0	34	theme	sunflower	127:135	arg1	responses					114:122	growth, yield and tolerance responses	86:122	growth, yield and tolerance responses of sunflower	86:135	Pseudomonas entomophila PE3 and its exopolysaccharides as biostimulants for enhancing growth, yield and tolerance responses of sunflower under saline conditions.
33360750	3	35	theme	acetic	500:505	arg1	IAA					513:515	IAA	513:515	IAA	513:515	The isolate produced indole acetic acid (IAA), gibberellic acid (GA), exopolysaccharides (EPS) and siderophore along with the potential to solubilize potassium (K), zinc (Zn) and phosphorus (P).
33360750	3	35	theme	acetic	500:505	arg1	acid					507:510	indole acetic acid	493:510	indole acetic acid (IAA)	493:516	The isolate produced indole acetic acid (IAA), gibberellic acid (GA), exopolysaccharides (EPS) and siderophore along with the potential to solubilize potassium (K), zinc (Zn) and phosphorus (P).
33360750	4	36	theme	PGP	690:692	arg1	attributes					694:703	PGP attributes	690:703	PGP attributes	690:703	Maximum stimulation of PGP attributes was recorded at 2% NaCl concentration.
33360750	1	37	theme	productivity	311:322	arg1	strategy					336:343	a potential eco-friendly remediation and productivity enhancement strategy	270:343	strategy	336:343	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions can be a potential eco-friendly remediation and productivity enhancement strategy.
33360750	7	38	theme	extracted	996:1004	arg1	EPS					1006:1008	The extracted EPS	992:1008	The extracted EPS	992:1008	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	7	39	theme	Na+	1179:1181	arg1	accumulation					1183:1194	Na+ accumulation	1179:1194	Na+ accumulation	1179:1194	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	9	40	theme	PE3	1353:1355	arg1	bioformulation					1327:1340	EPS based bioformulation	1317:1340	EPS based bioformulation of isolate PE3	1317:1355	Finally, EPS based bioformulation of isolate PE3 was checked through field assay in saline soil.
33360750	10	41	theme	inoculated	1494:1503	arg1	plants					1515:1520	inoculated sunflower plants	1494:1520	inoculated sunflower plants	1494:1520	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	1	42	theme	enhancement	324:334	arg1	strategy					336:343	a potential eco-friendly remediation and productivity enhancement strategy	270:343	strategy	336:343	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions can be a potential eco-friendly remediation and productivity enhancement strategy.
33360750	0	43	theme	saline	143:148	arg1	conditions					150:159	saline conditions	143:159	saline conditions	143:159	Pseudomonas entomophila PE3 and its exopolysaccharides as biostimulants for enhancing growth, yield and tolerance responses of sunflower under saline conditions.
33360750	7	44	theme	reducing	1116:1123	arg1	power					1125:1129	power	1125:1129	power	1125:1129	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	9	45	theme	field	1377:1381	arg1	assay					1383:1387	field assay	1377:1387	field assay	1377:1387	Finally, EPS based bioformulation of isolate PE3 was checked through field assay in saline soil.
33360750	1	46	theme	associated	216:225	arg1	metabolites					227:237	the associated metabolites	212:237	the associated metabolites	212:237	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions can be a potential eco-friendly remediation and productivity enhancement strategy.
33360750	7	47	theme	hydroxyl	1086:1093	arg1	activity					1106:1113	hydroxyl scavenging activity	1086:1113	hydroxyl scavenging activity	1086:1113	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	8	48	theme	salt	1224:1227	arg1	properties					1239:1248	the salt tolerance properties	1220:1248	the salt tolerance properties of EPS	1220:1255	Interestingly, the salt tolerance properties of EPS were enhanced upon exposure to salinity (2% NaCl).
33360750	2	49	dep	promoting	448:456	arg1	plant					435:439	plant	435:439	plant	435:439	Salt-tolerant Pseudomonas entomophila PE3 was isolated from saline soil and screened for plant growth promoting (PGP) traits.
33360750	2	49	dep	promoting	448:456	arg1	growth					441:446	growth	441:446	growth	441:446	Salt-tolerant Pseudomonas entomophila PE3 was isolated from saline soil and screened for plant growth promoting (PGP) traits.
33360750	2	49	dep	promoting	448:456	arg1	PGP					459:461	PGP	459:461	PGP	459:461	Salt-tolerant Pseudomonas entomophila PE3 was isolated from saline soil and screened for plant growth promoting (PGP) traits.
33360750	2	50	theme	promoting	448:456	arg1	traits					464:469	plant growth promoting (PGP) traits	435:469	plant growth promoting (PGP) traits	435:469	Salt-tolerant Pseudomonas entomophila PE3 was isolated from saline soil and screened for plant growth promoting (PGP) traits.
33360750	10	51	theme	tolerance	1470:1478	arg1	attributes					1480:1489	growth promotion and improved salinity tolerance attributes	1431:1489	growth promotion and improved salinity tolerance attributes of inoculated sunflower plants	1431:1520	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	5	52	dep	analyzed	796:803	arg1	concentrations					824:837	different salt concentrations	809:837	different salt concentrations	809:837	To determine the role of EPS, their composition was analyzed (at different salt concentrations) and comparison was done to determine the changes upon exposure to salinity.
33360750	8	53	theme	%	1299:1299	arg1	NaCl					1301:1304	2% NaCl	1298:1304	2% NaCl	1298:1304	Interestingly, the salt tolerance properties of EPS were enhanced upon exposure to salinity (2% NaCl).
33360750	8	53	theme	%	1299:1299	arg1	salinity					1288:1295	salinity	1288:1295	salinity (2% NaCl)	1288:1305	Interestingly, the salt tolerance properties of EPS were enhanced upon exposure to salinity (2% NaCl).
33360750	4	54	theme	Maximum	667:673	arg1	stimulation					675:685	Maximum stimulation	667:685	Maximum stimulation of PGP attributes	667:703	Maximum stimulation of PGP attributes was recorded at 2% NaCl concentration.
33360750	10	55	theme	PE3	1545:1547	arg1	bioformulation					1527:1540	the bioformulation	1523:1540	the bioformulation of PE3 amended with EPS	1523:1564	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	10	55	theme	PE3	1545:1547	arg1	breakthrough					1575:1586	a breakthrough	1573:1586	a breakthrough for remediation of saline-agroecosystems	1573:1627	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	10	56	theme	promotion	1438:1446	arg1	attributes					1480:1489	growth promotion and improved salinity tolerance attributes	1431:1489	growth promotion and improved salinity tolerance attributes of inoculated sunflower plants	1431:1520	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	8	57	theme	tolerance	1229:1237	arg1	properties					1239:1248	the salt tolerance properties	1220:1248	the salt tolerance properties of EPS	1220:1255	Interestingly, the salt tolerance properties of EPS were enhanced upon exposure to salinity (2% NaCl).
33360750	10	58	theme	growth	1431:1436	arg1	promotion					1438:1446	growth promotion	1431:1446	growth promotion	1431:1446	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	2	59	dep	Pseudomonas	360:370	arg1	entomophila					372:382	entomophila	372:382	entomophila	372:382	Salt-tolerant Pseudomonas entomophila PE3 was isolated from saline soil and screened for plant growth promoting (PGP) traits.
33360750	5	60	theme	EPS	769:771	arg1	role					761:764	the role	757:764	the role of EPS	757:771	To determine the role of EPS, their composition was analyzed (at different salt concentrations) and comparison was done to determine the changes upon exposure to salinity.
33360750	10	61	theme	saline-agroecosystems	1607:1627	arg1	remediation					1592:1602	remediation	1592:1602	remediation of saline-agroecosystems	1592:1627	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	1	62	theme	saline	245:250	arg1	conditions					252:261	saline conditions	245:261	saline conditions	245:261	Evaluation of plant growth promoting bacteria and the associated metabolites under saline conditions can be a potential eco-friendly remediation and productivity enhancement strategy.
33360750	10	63	theme	promising	1410:1418	arg1	results					1420:1426	promising results	1410:1426	promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants	1410:1520	With promising results on growth promotion and improved salinity tolerance attributes of inoculated sunflower plants, the bioformulation of PE3 amended with EPS can be a breakthrough for remediation of saline-agroecosystems.
33360750	3	64	theme	indole	493:498	arg1	IAA					513:515	IAA	513:515	IAA	513:515	The isolate produced indole acetic acid (IAA), gibberellic acid (GA), exopolysaccharides (EPS) and siderophore along with the potential to solubilize potassium (K), zinc (Zn) and phosphorus (P).
33360750	3	64	theme	indole	493:498	arg1	acid					507:510	indole acetic acid	493:510	indole acetic acid (IAA)	493:516	The isolate produced indole acetic acid (IAA), gibberellic acid (GA), exopolysaccharides (EPS) and siderophore along with the potential to solubilize potassium (K), zinc (Zn) and phosphorus (P).
33360750	6	65	theme	phenolic	972:979	arg1	compounds					981:989	phenolic compounds	972:989	phenolic compounds	972:989	EPS was found to be rich in carbohydrates, proteins and phenolic compounds.
33360750	5	66	theme	salt	819:822	arg1	concentrations					824:837	different salt concentrations	809:837	different salt concentrations	809:837	To determine the role of EPS, their composition was analyzed (at different salt concentrations) and comparison was done to determine the changes upon exposure to salinity.
33360750	9	67	theme	EPS	1317:1319	arg1	bioformulation					1327:1340	EPS based bioformulation	1317:1340	EPS based bioformulation of isolate PE3	1317:1355	Finally, EPS based bioformulation of isolate PE3 was checked through field assay in saline soil.
33360750	9	68	theme	isolate	1345:1351	arg1	PE3					1353:1355	isolate PE3	1345:1355	isolate PE3	1345:1355	Finally, EPS based bioformulation of isolate PE3 was checked through field assay in saline soil.
33360750	0	69	dep	Pseudomonas	0:10	arg1	entomophila					12:22	entomophila	12:22	entomophila	12:22	Pseudomonas entomophila PE3 and its exopolysaccharides as biostimulants for enhancing growth, yield and tolerance responses of sunflower under saline conditions.
33360750	7	70	contain	possess	1029:1035	arg2	antioxidant					1073:1083	antioxidant	1073:1083	antioxidant	1073:1083	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	7	70	contain	possess	1029:1035	arg1	EPS					1006:1008	The extracted EPS	992:1008	The extracted EPS	992:1008	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	7	70	contain	possess	1029:1035	arg2	properties					1052:1061	salt-tolerance properties	1037:1061	salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability	1037:1202	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	7	70	contain	possess	1029:1035	arg2	power					1125:1129	power	1125:1129	power	1125:1129	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	7	70	contain	possess	1029:1035	arg2	activity					1106:1113	hydroxyl scavenging activity	1086:1113	hydroxyl scavenging activity	1086:1113	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	7	70	contain	possess	1029:1035	arg2	accumulation					1183:1194	Na+ accumulation	1179:1194	Na+ accumulation	1179:1194	The extracted EPS were also found to possess salt-tolerance properties including antioxidant, hydroxyl scavenging activity, reducing power, emulsification and flocculation potential, and Na+ accumulation ability.
33360750	9	71	theme	based	1321:1325	arg1	bioformulation					1327:1340	EPS based bioformulation	1317:1340	EPS based bioformulation of isolate PE3	1317:1355	Finally, EPS based bioformulation of isolate PE3 was checked through field assay in saline soil.
33814148	0	0	theme	analysis	62:69	arg1	approach					71:78	A path analysis approach	55:78	A path analysis approach	55:78	Coagulation process in Manchega sheep milk from Spain: A path analysis approach.
33814148	8	1	theme	lactose	1156:1162	arg1	concentration					1164:1176	lactose concentration	1156:1176	lactose concentration	1156:1176	Factors that directly affected curd yield were fat content, lactose concentration, casein content, and curd moisture.
33814148	8	2	theme	curd	1199:1202	arg1	moisture					1204:1211	curd moisture	1199:1211	curd moisture	1199:1211	Factors that directly affected curd yield were fat content, lactose concentration, casein content, and curd moisture.
33814148	0	3	theme	path	57:60	arg1	approach					71:78	A path analysis approach	55:78	A path analysis approach	55:78	Coagulation process in Manchega sheep milk from Spain: A path analysis approach.
33814148	0	4	from	process	12:18	arg1	milk					38:41	Manchega sheep milk	23:41	Manchega sheep milk from Spain	23:52	Coagulation process in Manchega sheep milk from Spain: A path analysis approach.
33814148	0	4	from	process	12:18	arg1	Spain					48:52	Spain	48:52	Spain	48:52	Coagulation process in Manchega sheep milk from Spain: A path analysis approach.
33814148	7	5	theme	somatic	1001:1007	arg1	cells					1009:1013	somatic cells	1001:1013	somatic cells	1001:1013	Contrastingly, somatic cells did not seem to have any effect (direct or indirect) on the coagulation process.
33814148	6	6	theme	casein	946:951	arg1	content					953:959	casein content	946:959	casein content	946:959	Results showed that the factors that had a direct influence on milk coagulation were lactose concentration, casein content, and initial pH of milk.
33814148	3	7	theme	hygienic	330:337	arg1	quality					339:345	hygienic quality	330:345	hygienic quality	330:345	This study assessed composition, hygienic quality, coagulation properties, and curd yield of 1,200 individual Manchega sheep milk samples.
33814148	4	8	from	effect	463:468	arg1	curdling					525:532	curdling	525:532	curdling	525:532	The aim was to compare the effect of composition and hygienic quality on coagulation and curdling, and to evaluate the relationship between curd yields and the coagulation process and the effect of other features by using path analysis methodologies.
33814148	4	8	from	effect	463:468	arg1	coagulation					509:519	coagulation	509:519	coagulation	509:519	The aim was to compare the effect of composition and hygienic quality on coagulation and curdling, and to evaluate the relationship between curd yields and the coagulation process and the effect of other features by using path analysis methodologies.
33814148	0	9	from	Spain	48:52	arg1	milk					38:41	Manchega sheep milk	23:41	Manchega sheep milk from Spain	23:52	Coagulation process in Manchega sheep milk from Spain: A path analysis approach.
33814148	0	9	from	Spain	48:52	arg1	process					12:18	Coagulation process	0:18	Coagulation process in Manchega sheep milk from Spain	0:52	Coagulation process in Manchega sheep milk from Spain: A path analysis approach.
33814148	5	10	theme	path	703:706	arg1	tool					746:749	a useful and effective tool	723:749	a useful and effective tool to assess these relationships through direct and indirect paths within the same model	723:835	Outcomes proved path analysis to be a useful and effective tool to assess these relationships through direct and indirect paths within the same model.
33814148	5	10	theme	path	703:706	arg1	analysis					708:715	path analysis	703:715	path analysis	703:715	Outcomes proved path analysis to be a useful and effective tool to assess these relationships through direct and indirect paths within the same model.
33814148	4	11	theme	analysis	663:670	arg1	methodologies					672:684	path analysis methodologies	658:684	path analysis methodologies	658:684	The aim was to compare the effect of composition and hygienic quality on coagulation and curdling, and to evaluate the relationship between curd yields and the coagulation process and the effect of other features by using path analysis methodologies.
33814148	2	12	theme	existing	237:244	arg1	relationships					246:258	the existing relationships	233:258	the existing relationships between these variables	233:282	However, the existing relationships between these variables are complex.
33814148	2	12	theme	existing	237:244	arg1	complex					288:294	complex	288:294	complex	288:294	However, the existing relationships between these variables are complex.
33814148	1	13	theme	dairy	141:145	arg1	industry					147:154	the dairy industry	137:154	the dairy industry	137:154	Characteristics of sheep milk are of great interest for the dairy industry, as almost the totality of production is intended for cheesemaking.
33814148	9	14	theme	technological	1223:1235	arg1	parameters					1237:1246	technological parameters	1223:1246	technological parameters	1223:1246	However, technological parameters showed little effect over curd yield.
33814148	7	15	dep	effect	1040:1045	arg1	indirect					1058:1065	indirect	1058:1065	indirect	1058:1065	Contrastingly, somatic cells did not seem to have any effect (direct or indirect) on the coagulation process.
33814148	7	15	dep	effect	1040:1045	arg1	direct					1048:1053	direct	1048:1053	direct	1048:1053	Contrastingly, somatic cells did not seem to have any effect (direct or indirect) on the coagulation process.
33814148	0	16	dep	approach	71:78	arg1	process					12:18	Coagulation process	0:18	Coagulation process in Manchega sheep milk from Spain	0:52	Coagulation process in Manchega sheep milk from Spain: A path analysis approach.
33814148	3	17	theme	sheep	416:420	arg1	samples					427:433	1,200 individual Manchega sheep milk samples	390:433	1,200 individual Manchega sheep milk samples	390:433	This study assessed composition, hygienic quality, coagulation properties, and curd yield of 1,200 individual Manchega sheep milk samples.
33814148	5	18	theme	useful	725:730	arg1	tool					746:749	a useful and effective tool	723:749	a useful and effective tool to assess these relationships through direct and indirect paths within the same model	723:835	Outcomes proved path analysis to be a useful and effective tool to assess these relationships through direct and indirect paths within the same model.
33814148	5	18	theme	useful	725:730	arg1	analysis					708:715	path analysis	703:715	path analysis	703:715	Outcomes proved path analysis to be a useful and effective tool to assess these relationships through direct and indirect paths within the same model.
33814148	5	19	theme	same	826:829	arg1	model					831:835	the same model	822:835	the same model	822:835	Outcomes proved path analysis to be a useful and effective tool to assess these relationships through direct and indirect paths within the same model.
33814148	0	20	theme	Coagulation	0:10	arg1	process					12:18	Coagulation process	0:18	Coagulation process in Manchega sheep milk from Spain	0:52	Coagulation process in Manchega sheep milk from Spain: A path analysis approach.
33814148	6	21	theme	lactose	923:929	arg1	factors					862:868	the factors	858:868	the factors that had a direct influence on milk coagulation	858:916	Results showed that the factors that had a direct influence on milk coagulation were lactose concentration, casein content, and initial pH of milk.
33814148	6	21	theme	lactose	923:929	arg1	concentration					931:943	lactose concentration	923:943	lactose concentration	923:943	Results showed that the factors that had a direct influence on milk coagulation were lactose concentration, casein content, and initial pH of milk.
33814148	3	22	theme	individual	396:405	arg1	samples					427:433	1,200 individual Manchega sheep milk samples	390:433	1,200 individual Manchega sheep milk samples	390:433	This study assessed composition, hygienic quality, coagulation properties, and curd yield of 1,200 individual Manchega sheep milk samples.
33814148	0	23	theme	Manchega	23:30	arg1	milk					38:41	Manchega sheep milk	23:41	Manchega sheep milk from Spain	23:52	Coagulation process in Manchega sheep milk from Spain: A path analysis approach.
33814148	9	24	theme	little	1255:1260	arg1	effect					1262:1267	little effect	1255:1267	little effect	1255:1267	However, technological parameters showed little effect over curd yield.
33814148	6	25	theme	milk	980:983	arg1	factors					862:868	the factors	858:868	the factors that had a direct influence on milk coagulation	858:916	Results showed that the factors that had a direct influence on milk coagulation were lactose concentration, casein content, and initial pH of milk.
33814148	6	25	theme	milk	980:983	arg1	concentration					931:943	lactose concentration	923:943	lactose concentration	923:943	Results showed that the factors that had a direct influence on milk coagulation were lactose concentration, casein content, and initial pH of milk.
33814148	6	25	theme	milk	980:983	arg1	content					953:959	casein content	946:959	casein content	946:959	Results showed that the factors that had a direct influence on milk coagulation were lactose concentration, casein content, and initial pH of milk.
33814148	6	25	theme	milk	980:983	arg1	pH					974:975	initial pH	966:975	initial pH of milk	966:983	Results showed that the factors that had a direct influence on milk coagulation were lactose concentration, casein content, and initial pH of milk.
33814148	5	26	theme	direct	789:794	arg1	paths					809:813	direct and indirect paths	789:813	direct and indirect paths within the same model	789:835	Outcomes proved path analysis to be a useful and effective tool to assess these relationships through direct and indirect paths within the same model.
33814148	3	27	theme	coagulation	348:358	arg1	properties					360:369	coagulation properties	348:369	coagulation properties	348:369	This study assessed composition, hygienic quality, coagulation properties, and curd yield of 1,200 individual Manchega sheep milk samples.
33814148	4	28	theme	features	640:647	arg1	effect					624:629	the effect	620:629	the effect of other features	620:647	The aim was to compare the effect of composition and hygienic quality on coagulation and curdling, and to evaluate the relationship between curd yields and the coagulation process and the effect of other features by using path analysis methodologies.
33814148	4	28	theme	features	640:647	arg1	relationship					555:566	the relationship	551:566	the relationship between curd yields and the coagulation process	551:614	The aim was to compare the effect of composition and hygienic quality on coagulation and curdling, and to evaluate the relationship between curd yields and the coagulation process and the effect of other features by using path analysis methodologies.
33814148	4	29	theme	path	658:661	arg1	methodologies					672:684	path analysis methodologies	658:684	path analysis methodologies	658:684	The aim was to compare the effect of composition and hygienic quality on coagulation and curdling, and to evaluate the relationship between curd yields and the coagulation process and the effect of other features by using path analysis methodologies.
33814148	5	30	theme	indirect	800:807	arg1	paths					809:813	direct and indirect paths	789:813	direct and indirect paths within the same model	789:835	Outcomes proved path analysis to be a useful and effective tool to assess these relationships through direct and indirect paths within the same model.
33814148	6	31	theme	milk	901:904	arg1	coagulation					906:916	milk coagulation	901:916	milk coagulation	901:916	Results showed that the factors that had a direct influence on milk coagulation were lactose concentration, casein content, and initial pH of milk.
33814148	6	32	contain	had	875:877	arg1	factors					862:868	the factors	858:868	the factors that had a direct influence on milk coagulation	858:916	Results showed that the factors that had a direct influence on milk coagulation were lactose concentration, casein content, and initial pH of milk.
33814148	6	32	contain	had	875:877	arg1	concentration					931:943	lactose concentration	923:943	lactose concentration	923:943	Results showed that the factors that had a direct influence on milk coagulation were lactose concentration, casein content, and initial pH of milk.
33814148	6	32	contain	had	875:877	arg2	influence					888:896	a direct influence	879:896	a direct influence	879:896	Results showed that the factors that had a direct influence on milk coagulation were lactose concentration, casein content, and initial pH of milk.
33814148	3	33	theme	milk	422:425	arg1	samples					427:433	1,200 individual Manchega sheep milk samples	390:433	1,200 individual Manchega sheep milk samples	390:433	This study assessed composition, hygienic quality, coagulation properties, and curd yield of 1,200 individual Manchega sheep milk samples.
33814148	0	34	theme	sheep	32:36	arg1	milk					38:41	Manchega sheep milk	23:41	Manchega sheep milk from Spain	23:52	Coagulation process in Manchega sheep milk from Spain: A path analysis approach.
33814148	4	35	theme	hygienic	489:496	arg1	quality					498:504	hygienic quality	489:504	hygienic quality	489:504	The aim was to compare the effect of composition and hygienic quality on coagulation and curdling, and to evaluate the relationship between curd yields and the coagulation process and the effect of other features by using path analysis methodologies.
33814148	5	36	theme	effective	736:744	arg1	tool					746:749	a useful and effective tool	723:749	a useful and effective tool to assess these relationships through direct and indirect paths within the same model	723:835	Outcomes proved path analysis to be a useful and effective tool to assess these relationships through direct and indirect paths within the same model.
33814148	5	36	theme	effective	736:744	arg1	analysis					708:715	path analysis	703:715	path analysis	703:715	Outcomes proved path analysis to be a useful and effective tool to assess these relationships through direct and indirect paths within the same model.
33814148	4	37	theme	composition	473:483	arg1	effect					463:468	the effect	459:468	the effect of composition and hygienic quality on coagulation and curdling	459:532	The aim was to compare the effect of composition and hygienic quality on coagulation and curdling, and to evaluate the relationship between curd yields and the coagulation process and the effect of other features by using path analysis methodologies.
33814148	3	38	theme	samples	427:433	arg1	properties					360:369	coagulation properties	348:369	coagulation properties	348:369	This study assessed composition, hygienic quality, coagulation properties, and curd yield of 1,200 individual Manchega sheep milk samples.
33814148	3	38	theme	samples	427:433	arg1	yield					381:385	curd yield	376:385	curd yield	376:385	This study assessed composition, hygienic quality, coagulation properties, and curd yield of 1,200 individual Manchega sheep milk samples.
33814148	3	38	theme	samples	427:433	arg1	composition					317:327	composition	317:327	composition	317:327	This study assessed composition, hygienic quality, coagulation properties, and curd yield of 1,200 individual Manchega sheep milk samples.
33814148	3	38	theme	samples	427:433	arg1	quality					339:345	hygienic quality	330:345	hygienic quality	330:345	This study assessed composition, hygienic quality, coagulation properties, and curd yield of 1,200 individual Manchega sheep milk samples.
33814148	8	39	theme	fat	1143:1145	arg1	content					1147:1153	fat content	1143:1153	fat content	1143:1153	Factors that directly affected curd yield were fat content, lactose concentration, casein content, and curd moisture.
33814148	9	40	theme	curd	1274:1277	arg1	yield					1279:1283	curd yield	1274:1283	curd yield	1274:1283	However, technological parameters showed little effect over curd yield.
33814148	8	41	theme	curd	1127:1130	arg1	yield					1132:1136	curd yield	1127:1136	curd yield	1127:1136	Factors that directly affected curd yield were fat content, lactose concentration, casein content, and curd moisture.
33814148	3	42	theme	Manchega	407:414	arg1	samples					427:433	1,200 individual Manchega sheep milk samples	390:433	1,200 individual Manchega sheep milk samples	390:433	This study assessed composition, hygienic quality, coagulation properties, and curd yield of 1,200 individual Manchega sheep milk samples.
33814148	1	43	theme	sheep	100:104	arg1	milk					106:109	sheep milk	100:109	sheep milk	100:109	Characteristics of sheep milk are of great interest for the dairy industry, as almost the totality of production is intended for cheesemaking.
33814148	3	44	theme	curd	376:379	arg1	yield					381:385	curd yield	376:385	curd yield	376:385	This study assessed composition, hygienic quality, coagulation properties, and curd yield of 1,200 individual Manchega sheep milk samples.
33814148	6	45	theme	direct	881:886	arg1	influence					888:896	a direct influence	879:896	a direct influence	879:896	Results showed that the factors that had a direct influence on milk coagulation were lactose concentration, casein content, and initial pH of milk.
33814148	1	46	theme	milk	106:109	arg1	Characteristics					81:95	Characteristics	81:95	Characteristics of sheep milk	81:109	Characteristics of sheep milk are of great interest for the dairy industry, as almost the totality of production is intended for cheesemaking.
33814148	4	47	theme	quality	498:504	arg1	effect					463:468	the effect	459:468	the effect of composition and hygienic quality on coagulation and curdling	459:532	The aim was to compare the effect of composition and hygienic quality on coagulation and curdling, and to evaluate the relationship between curd yields and the coagulation process and the effect of other features by using path analysis methodologies.
33814148	1	48	theme	production	183:192	arg1	totality					171:178	almost the totality	160:178	almost the totality of production	160:192	Characteristics of sheep milk are of great interest for the dairy industry, as almost the totality of production is intended for cheesemaking.
33814148	7	49	contain	have	1031:1034	arg2	effect					1040:1045	any effect	1036:1045	any effect (direct or indirect)	1036:1066	Contrastingly, somatic cells did not seem to have any effect (direct or indirect) on the coagulation process.
33814148	7	49	contain	have	1031:1034	arg1	cells					1009:1013	somatic cells	1001:1013	somatic cells	1001:1013	Contrastingly, somatic cells did not seem to have any effect (direct or indirect) on the coagulation process.
33814148	6	50	theme	initial	966:972	arg1	pH					974:975	initial pH	966:975	initial pH of milk	966:983	Results showed that the factors that had a direct influence on milk coagulation were lactose concentration, casein content, and initial pH of milk.
33814148	4	51	theme	coagulation	596:606	arg1	process					608:614	the coagulation process	592:614	the coagulation process	592:614	The aim was to compare the effect of composition and hygienic quality on coagulation and curdling, and to evaluate the relationship between curd yields and the coagulation process and the effect of other features by using path analysis methodologies.
33814148	8	52	theme	casein	1179:1184	arg1	content					1186:1192	casein content	1179:1192	casein content	1179:1192	Factors that directly affected curd yield were fat content, lactose concentration, casein content, and curd moisture.
33814148	1	53	theme	great	118:122	arg1	interest					124:131	great interest	118:131	great interest for the dairy industry	118:154	Characteristics of sheep milk are of great interest for the dairy industry, as almost the totality of production is intended for cheesemaking.
33814148	7	54	theme	coagulation	1075:1085	arg1	process					1087:1093	the coagulation process	1071:1093	the coagulation process	1071:1093	Contrastingly, somatic cells did not seem to have any effect (direct or indirect) on the coagulation process.
33814148	4	55	theme	other	634:638	arg1	features					640:647	other features	634:647	other features	634:647	The aim was to compare the effect of composition and hygienic quality on coagulation and curdling, and to evaluate the relationship between curd yields and the coagulation process and the effect of other features by using path analysis methodologies.
33814148	4	56	theme	curd	576:579	arg1	yields					581:586	curd yields	576:586	curd yields	576:586	The aim was to compare the effect of composition and hygienic quality on coagulation and curdling, and to evaluate the relationship between curd yields and the coagulation process and the effect of other features by using path analysis methodologies.
32846907	8	0	theme	potential	1137:1145	arg1	CCGA					1115:1118	the electrothermal CCGA	1096:1118	the electrothermal CCGA	1096:1118	Consequently, the electrothermal CCGA can be used as a potential lightweight substrate for efficient electrothermal devices.
32846907	8	0	theme	potential	1137:1145	arg1	substrate					1159:1167	a potential lightweight substrate	1135:1167	a potential lightweight substrate for efficient electrothermal devices	1135:1204	Consequently, the electrothermal CCGA can be used as a potential lightweight substrate for efficient electrothermal devices.
32846907	7	1	theme	three-dimensional	1012:1028	arg1	conducive					1050:1058	conducive	1050:1058	conducive	1050:1058	The formed three-dimensional porous structure is conducive to the heat exchange.
32846907	7	1	theme	three-dimensional	1012:1028	arg1	structure					1037:1045	The formed three-dimensional porous structure	1001:1045	The formed three-dimensional porous structure	1001:1045	The formed three-dimensional porous structure is conducive to the heat exchange.
32846907	5	2	from	m-2	822:824	arg1	rise					769:772	the maximum steady-state temperature rise	732:772	the maximum steady-state temperature rise	732:772	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	2	from	m-2	822:824	arg1	CCGA					792:795	electrothermal CCGA	777:795	electrothermal CCGA at 3000 W m-2 and 2000 W m-2	777:824	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	2	from	m-2	822:824	arg1	%					729:729	%	729:729	%	729:729	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	4	3	theme	mg	696:697	arg1	concentration					644:656	the concentration	640:656	the concentration of the NFC/MWCNTs/GP suspension	640:688	The results show that when the concentration of the NFC/MWCNTs/GP suspension was 5 mg mL-1 and NFC amount was 80 wt.
32846907	4	3	theme	mg	696:697	arg1	mL-1					699:702	5 mg mL-1	694:702	5 mg mL-1	694:702	The results show that when the concentration of the NFC/MWCNTs/GP suspension was 5 mg mL-1 and NFC amount was 80 wt.
32846907	5	4	theme	maximum	736:742	arg1	rise					769:772	the maximum steady-state temperature rise	732:772	the maximum steady-state temperature rise	732:772	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	4	theme	maximum	736:742	arg1	CCGA					792:795	electrothermal CCGA	777:795	electrothermal CCGA at 3000 W m-2 and 2000 W m-2	777:824	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	4	theme	maximum	736:742	arg1	%					729:729	%	729:729	%	729:729	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	7	5	theme	porous	1030:1035	arg1	conducive					1050:1058	conducive	1050:1058	conducive	1050:1058	The formed three-dimensional porous structure is conducive to the heat exchange.
32846907	7	5	theme	porous	1030:1035	arg1	structure					1037:1045	The formed three-dimensional porous structure	1001:1045	The formed three-dimensional porous structure	1001:1045	The formed three-dimensional porous structure is conducive to the heat exchange.
32846907	7	6	theme	formed	1005:1010	arg1	conducive					1050:1058	conducive	1050:1058	conducive	1050:1058	The formed three-dimensional porous structure is conducive to the heat exchange.
32846907	7	6	theme	formed	1005:1010	arg1	structure					1037:1045	The formed three-dimensional porous structure	1001:1045	The formed three-dimensional porous structure	1001:1045	The formed three-dimensional porous structure is conducive to the heat exchange.
32846907	1	7	theme	porous	282:287	arg1	aerogel					314:320	porous NFC based electrothermal aerogel	282:320	porous NFC based electrothermal aerogel	282:320	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	2	8	theme	freeze-drying	506:518	arg1	method					520:525	a simple and economic freeze-drying method	484:525	a simple and economic freeze-drying method	484:525	Therefore, this work used NFC as a skeleton, combined with multi-walled carbon nanotubes (MWCNTs) and graphene (GP), to prepare NFC/MWCNTs/GP aerogel (CCGA) via a simple and economic freeze-drying method.
32846907	1	9	theme	NFC	289:291	arg1	aerogel					314:320	porous NFC based electrothermal aerogel	282:320	porous NFC based electrothermal aerogel	282:320	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	2	10	theme	economic	497:504	arg1	method					520:525	a simple and economic freeze-drying method	484:525	a simple and economic freeze-drying method	484:525	Therefore, this work used NFC as a skeleton, combined with multi-walled carbon nanotubes (MWCNTs) and graphene (GP), to prepare NFC/MWCNTs/GP aerogel (CCGA) via a simple and economic freeze-drying method.
32846907	1	11	contain	has	187:189	arg1	cellulose					121:129	Nanofibrillated cellulose	105:129	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material	105:185	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	1	11	contain	has	187:189	arg1	NFC					132:134	NFC	132:134	NFC	132:134	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	1	11	contain	has	187:189	arg2	superiority					191:201	superiority	191:201	superiority for flexible electrothermal composite	191:239	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	6	12	from	concentration	935:947	arg1	%					926:926	nearly 15%	917:926	nearly 15%	917:926	The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL-1 under the power density of 2000 W m-2.
32846907	6	12	from	concentration	935:947	arg1	rate					896:899	The resistance change rate	874:899	The resistance change rate of the CCGA	874:911	The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL-1 under the power density of 2000 W m-2.
32846907	3	13	theme	electrothermal	532:545	arg1	CCGA					547:550	The electrothermal CCGA	528:550	The electrothermal CCGA	528:550	The electrothermal CCGA was finally assembled after connecting CCGA with electrodes.
32846907	1	14	theme	based	293:297	arg1	aerogel					314:320	porous NFC based electrothermal aerogel	282:320	porous NFC based electrothermal aerogel	282:320	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	6	15	theme	W	994:994	arg1	m-2					996:998	2000 W m-2	989:998	2000 W m-2	989:998	The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL-1 under the power density of 2000 W m-2.
32846907	5	16	theme	electrothermal	777:790	arg1	CCGA					792:795	electrothermal CCGA	777:795	electrothermal CCGA at 3000 W m-2 and 2000 W m-2	777:824	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	4	17	theme	NFC/MWCNTs/GP	665:677	arg1	suspension					679:688	the NFC/MWCNTs/GP suspension	661:688	the NFC/MWCNTs/GP suspension	661:688	The results show that when the concentration of the NFC/MWCNTs/GP suspension was 5 mg mL-1 and NFC amount was 80 wt.
32846907	5	18	theme	W	820:820	arg1	m-2					822:824	2000 W m-2	815:824	2000 W m-2	815:824	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	2	19	theme	simple	486:491	arg1	method					520:525	a simple and economic freeze-drying method	484:525	a simple and economic freeze-drying method	484:525	Therefore, this work used NFC as a skeleton, combined with multi-walled carbon nanotubes (MWCNTs) and graphene (GP), to prepare NFC/MWCNTs/GP aerogel (CCGA) via a simple and economic freeze-drying method.
32846907	0	20	theme	Nanofibrillated	2:16	arg1	Aerogel					49:55	A Nanofibrillated Cellulose-Based Electrothermal Aerogel	0:55	A Nanofibrillated Cellulose-Based Electrothermal Aerogel	0:55	A Nanofibrillated Cellulose-Based Electrothermal Aerogel Constructed with Carbon Nanotubes and Graphene.
32846907	8	21	theme	lightweight	1147:1157	arg1	CCGA					1115:1118	the electrothermal CCGA	1096:1118	the electrothermal CCGA	1096:1118	Consequently, the electrothermal CCGA can be used as a potential lightweight substrate for efficient electrothermal devices.
32846907	8	21	theme	lightweight	1147:1157	arg1	substrate					1159:1167	a potential lightweight substrate	1135:1167	a potential lightweight substrate for efficient electrothermal devices	1135:1204	Consequently, the electrothermal CCGA can be used as a potential lightweight substrate for efficient electrothermal devices.
32846907	6	22	theme	CCGA	908:911	arg1	%					926:926	nearly 15%	917:926	nearly 15%	917:926	The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL-1 under the power density of 2000 W m-2.
32846907	6	22	theme	CCGA	908:911	arg1	rate					896:899	The resistance change rate	874:899	The resistance change rate of the CCGA	874:911	The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL-1 under the power density of 2000 W m-2.
32846907	1	23	theme	Nanofibrillated	105:119	arg1	cellulose					121:129	Nanofibrillated cellulose	105:129	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material	105:185	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	1	23	theme	Nanofibrillated	105:119	arg1	NFC					132:134	NFC	132:134	NFC	132:134	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	8	24	used	used	1127:1130	arg2	CCGA					1115:1118	the electrothermal CCGA	1096:1118	the electrothermal CCGA	1096:1118	Consequently, the electrothermal CCGA can be used as a potential lightweight substrate for efficient electrothermal devices.
32846907	8	24	used	used	1127:1130	arg2	substrate					1159:1167	a potential lightweight substrate	1135:1167	a potential lightweight substrate for efficient electrothermal devices	1135:1204	Consequently, the electrothermal CCGA can be used as a potential lightweight substrate for efficient electrothermal devices.
32846907	1	25	theme	flexible	207:214	arg1	composite					231:239	flexible electrothermal composite	207:239	flexible electrothermal composite	207:239	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	5	26	theme	CCGA	792:795	arg1	rise					769:772	the maximum steady-state temperature rise	732:772	the maximum steady-state temperature rise	732:772	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	26	theme	CCGA	792:795	arg1	CCGA					792:795	electrothermal CCGA	777:795	electrothermal CCGA at 3000 W m-2 and 2000 W m-2	777:824	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	26	theme	CCGA	792:795	arg1	%					729:729	%	729:729	%	729:729	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	1	27	theme	electrothermal	299:312	arg1	aerogel					314:320	porous NFC based electrothermal aerogel	282:320	porous NFC based electrothermal aerogel	282:320	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	4	28	theme	NFC	708:710	arg1	amount					712:717	NFC amount	708:717	NFC amount	708:717	The results show that when the concentration of the NFC/MWCNTs/GP suspension was 5 mg mL-1 and NFC amount was 80 wt.
32846907	2	29	theme	carbon	395:400	arg1	MWCNTs					413:418	MWCNTs	413:418	MWCNTs	413:418	Therefore, this work used NFC as a skeleton, combined with multi-walled carbon nanotubes (MWCNTs) and graphene (GP), to prepare NFC/MWCNTs/GP aerogel (CCGA) via a simple and economic freeze-drying method.
32846907	2	29	theme	carbon	395:400	arg1	nanotubes					402:410	multi-walled carbon nanotubes	382:410	multi-walled carbon nanotubes (MWCNTs)	382:419	Therefore, this work used NFC as a skeleton, combined with multi-walled carbon nanotubes (MWCNTs) and graphene (GP), to prepare NFC/MWCNTs/GP aerogel (CCGA) via a simple and economic freeze-drying method.
32846907	0	30	theme	Electrothermal	34:47	arg1	Aerogel					49:55	A Nanofibrillated Cellulose-Based Electrothermal Aerogel	0:55	A Nanofibrillated Cellulose-Based Electrothermal Aerogel	0:55	A Nanofibrillated Cellulose-Based Electrothermal Aerogel Constructed with Carbon Nanotubes and Graphene.
32846907	5	31	theme	W	805:805	arg1	m-2					807:809	3000 W m-2	800:809	3000 W m-2	800:809	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	0	32	theme	Cellulose-Based	18:32	arg1	Aerogel					49:55	A Nanofibrillated Cellulose-Based Electrothermal Aerogel	0:55	A Nanofibrillated Cellulose-Based Electrothermal Aerogel	0:55	A Nanofibrillated Cellulose-Based Electrothermal Aerogel Constructed with Carbon Nanotubes and Graphene.
32846907	2	33	theme	multi-walled	382:393	arg1	MWCNTs					413:418	MWCNTs	413:418	MWCNTs	413:418	Therefore, this work used NFC as a skeleton, combined with multi-walled carbon nanotubes (MWCNTs) and graphene (GP), to prepare NFC/MWCNTs/GP aerogel (CCGA) via a simple and economic freeze-drying method.
32846907	2	33	theme	multi-walled	382:393	arg1	nanotubes					402:410	multi-walled carbon nanotubes	382:410	multi-walled carbon nanotubes (MWCNTs)	382:419	Therefore, this work used NFC as a skeleton, combined with multi-walled carbon nanotubes (MWCNTs) and graphene (GP), to prepare NFC/MWCNTs/GP aerogel (CCGA) via a simple and economic freeze-drying method.
32846907	5	34	theme	steady-state	744:755	arg1	rise					769:772	the maximum steady-state temperature rise	732:772	the maximum steady-state temperature rise	732:772	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	34	theme	steady-state	744:755	arg1	CCGA					792:795	electrothermal CCGA	777:795	electrothermal CCGA at 3000 W m-2 and 2000 W m-2	777:824	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	34	theme	steady-state	744:755	arg1	%					729:729	%	729:729	%	729:729	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	8	35	theme	electrothermal	1183:1196	arg1	devices					1198:1204	efficient electrothermal devices	1173:1204	efficient electrothermal devices	1173:1204	Consequently, the electrothermal CCGA can be used as a potential lightweight substrate for efficient electrothermal devices.
32846907	1	36	theme	electrothermal	216:229	arg1	composite					231:239	flexible electrothermal composite	207:239	flexible electrothermal composite	207:239	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	6	37	theme	mg	954:955	arg1	mL-1					957:960	7 mg mL-1	952:960	7 mg mL-1	952:960	The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL-1 under the power density of 2000 W m-2.
32846907	5	38	theme	temperature	757:767	arg1	rise					769:772	the maximum steady-state temperature rise	732:772	the maximum steady-state temperature rise	732:772	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	38	theme	temperature	757:767	arg1	CCGA					792:795	electrothermal CCGA	777:795	electrothermal CCGA at 3000 W m-2 and 2000 W m-2	777:824	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	38	theme	temperature	757:767	arg1	%					729:729	%	729:729	%	729:729	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	6	39	theme	change	889:894	arg1	%					926:926	nearly 15%	917:926	nearly 15%	917:926	The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL-1 under the power density of 2000 W m-2.
32846907	6	39	theme	change	889:894	arg1	rate					896:899	The resistance change rate	874:899	The resistance change rate of the CCGA	874:911	The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL-1 under the power density of 2000 W m-2.
32846907	8	40	theme	electrothermal	1100:1113	arg1	substrate					1159:1167	a potential lightweight substrate	1135:1167	a potential lightweight substrate for efficient electrothermal devices	1135:1204	Consequently, the electrothermal CCGA can be used as a potential lightweight substrate for efficient electrothermal devices.
32846907	8	40	theme	electrothermal	1100:1113	arg1	CCGA					1115:1118	the electrothermal CCGA	1096:1118	the electrothermal CCGA	1096:1118	Consequently, the electrothermal CCGA can be used as a potential lightweight substrate for efficient electrothermal devices.
32846907	6	41	theme	mL-1	957:960	arg1	concentration					935:947	the concentration	931:947	the concentration of 7 mg mL-1	931:960	The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL-1 under the power density of 2000 W m-2.
32846907	6	42	theme	power	972:976	arg1	density					978:984	the power density	968:984	the power density of 2000 W m-2	968:998	The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL-1 under the power density of 2000 W m-2.
32846907	2	43	theme	NFC/MWCNTs/GP	451:463	arg1	CCGA					474:477	CCGA	474:477	CCGA	474:477	Therefore, this work used NFC as a skeleton, combined with multi-walled carbon nanotubes (MWCNTs) and graphene (GP), to prepare NFC/MWCNTs/GP aerogel (CCGA) via a simple and economic freeze-drying method.
32846907	2	43	theme	NFC/MWCNTs/GP	451:463	arg1	aerogel					465:471	NFC/MWCNTs/GP aerogel	451:471	NFC/MWCNTs/GP aerogel (CCGA)	451:478	Therefore, this work used NFC as a skeleton, combined with multi-walled carbon nanotubes (MWCNTs) and graphene (GP), to prepare NFC/MWCNTs/GP aerogel (CCGA) via a simple and economic freeze-drying method.
32846907	6	44	theme	resistance	878:887	arg1	%					926:926	nearly 15%	917:926	nearly 15%	917:926	The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL-1 under the power density of 2000 W m-2.
32846907	6	44	theme	resistance	878:887	arg1	rate					896:899	The resistance change rate	874:899	The resistance change rate of the CCGA	874:911	The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL-1 under the power density of 2000 W m-2.
32846907	1	45	from	research	270:277	arg1	aerogel					314:320	porous NFC based electrothermal aerogel	282:320	porous NFC based electrothermal aerogel	282:320	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	4	46	theme	suspension	679:688	arg1	mL-1					699:702	5 mg mL-1	694:702	5 mg mL-1	694:702	The results show that when the concentration of the NFC/MWCNTs/GP suspension was 5 mg mL-1 and NFC amount was 80 wt.
32846907	4	46	theme	suspension	679:688	arg1	concentration					644:656	the concentration	640:656	the concentration of the NFC/MWCNTs/GP suspension	640:688	The results show that when the concentration of the NFC/MWCNTs/GP suspension was 5 mg mL-1 and NFC amount was 80 wt.
32846907	8	47	theme	efficient	1173:1181	arg1	devices					1198:1204	efficient electrothermal devices	1173:1204	efficient electrothermal devices	1173:1204	Consequently, the electrothermal CCGA can be used as a potential lightweight substrate for efficient electrothermal devices.
32846907	5	48	from	m-2	807:809	arg1	rise					769:772	the maximum steady-state temperature rise	732:772	the maximum steady-state temperature rise	732:772	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	48	from	m-2	807:809	arg1	CCGA					792:795	electrothermal CCGA	777:795	electrothermal CCGA at 3000 W m-2 and 2000 W m-2	777:824	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	48	from	m-2	807:809	arg1	%					729:729	%	729:729	%	729:729	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	49	from	%	729:729	arg1	m-2					822:824	2000 W m-2	815:824	2000 W m-2	815:824	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	5	49	from	%	729:729	arg1	m-2					807:809	3000 W m-2	800:809	3000 W m-2	800:809	%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m-2 and 2000 W m-2 was of about 62.0 °C and 40.4 °C, respectively.
32846907	1	50	theme	environmentally	143:157	arg1	material					178:185	an environmentally friendly substrate material	140:185	an environmentally friendly substrate material	140:185	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	6	51	theme	m-2	996:998	arg1	density					978:984	the power density	968:984	the power density of 2000 W m-2	968:998	The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL-1 under the power density of 2000 W m-2.
32846907	1	52	theme	friendly	159:166	arg1	material					178:185	an environmentally friendly substrate material	140:185	an environmentally friendly substrate material	140:185	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32846907	2	53	used	used	344:347	arg2	work					339:342	this work	334:342	this work	334:342	Therefore, this work used NFC as a skeleton, combined with multi-walled carbon nanotubes (MWCNTs) and graphene (GP), to prepare NFC/MWCNTs/GP aerogel (CCGA) via a simple and economic freeze-drying method.
32846907	0	54	theme	Carbon	74:79	arg1	Nanotubes					81:89	Carbon Nanotubes	74:89	Carbon Nanotubes	74:89	A Nanofibrillated Cellulose-Based Electrothermal Aerogel Constructed with Carbon Nanotubes and Graphene.
32846907	7	55	theme	heat	1067:1070	arg1	exchange					1072:1079	the heat exchange	1063:1079	the heat exchange	1063:1079	The formed three-dimensional porous structure is conducive to the heat exchange.
32846907	1	56	theme	substrate	168:176	arg1	material					178:185	an environmentally friendly substrate material	140:185	an environmentally friendly substrate material	140:185	Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel.
32155334	0	0	theme	Cellulose-Based	77:91	arg1	Matrices					93:100	Cellulose-Based Matrices	77:100	Cellulose-Based Matrices	77:100	Evaporation of Metals during the Thermal Treatment of Oxide Nanomaterials in Cellulose-Based Matrices.
32155334	6	1	theme	residues	1296:1303	arg1	analysis					1271:1278	a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis	1207:1278	a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues	1207:1303	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	6	2	theme	tubular	1209:1215	arg1	furnace					1217:1223	tubular furnace	1209:1223	tubular furnace	1209:1223	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	6	2	theme	tubular	1209:1215	arg1	Spectrometry					1257:1268	ICP Mass Spectrometry	1248:1268	ICP Mass Spectrometry	1248:1268	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	1	3	theme	last	153:156	arg1	waste					140:144	waste	140:144	waste	140:144	Like conventional material products, waste is the last stage of the life cycle of engineered nanomaterials, which are then incinerated or stabilized before disposal.
32155334	1	3	theme	last	153:156	arg1	stage					158:162	the last stage	149:162	the last stage of the life cycle of engineered nanomaterials, which are then incinerated or stabilized before disposal	149:266	Like conventional material products, waste is the last stage of the life cycle of engineered nanomaterials, which are then incinerated or stabilized before disposal.
32155334	5	4	theme	properties	1164:1173	arg1	gas					1128:1130	the flue gas	1119:1130	the flue gas independently of their chemical properties	1119:1173	It is shown that the matrix composition, such as chlorine and silicon, plays a key role in the evaporation of Cu and Zn at temperatures above 700 °C, while at relatively low temperatures (250 to 450 °C) the nanomaterials are most probably entrained in the flue gas independently of their chemical properties.
32155334	3	5	contain	containing	541:550	arg1	matrices					532:539	matrices	532:539	matrices containing organic and inorganic compounds	532:582	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	3	5	contain	containing	541:550	arg2	compounds					574:582	organic and inorganic compounds	552:582	organic and inorganic compounds	552:582	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	6	6	theme	Mass	1252:1255	arg1	furnace					1217:1223	tubular furnace	1209:1223	tubular furnace	1209:1223	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	6	6	theme	Mass	1252:1255	arg1	Spectrometry					1257:1268	ICP Mass Spectrometry	1248:1268	ICP Mass Spectrometry	1248:1268	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	4	7	theme	thermogravimetric	822:838	arg1	information					854:864	thermogravimetric and elemental information	822:864	thermogravimetric and elemental information	822:864	The latter, which combines a TGA (Thermogravimetric Analyzer) and an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer), offers the possibility to gain simultaneously thermogravimetric and elemental information.
32155334	3	8	from	nanomaterials	478:490	arg1	release					449:455	the thermal release	437:455	the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds	437:582	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	6	9	theme	evaporation	1345:1355	arg1	quantification					1317:1330	quantification	1317:1330	quantification of the metal evaporation from the three nanomaterials	1317:1384	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	6	10	from	nanomaterials	1372:1384	arg1	quantification					1317:1330	quantification	1317:1330	quantification of the metal evaporation from the three nanomaterials	1317:1384	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	6	10	from	nanomaterials	1372:1384	arg1	evaporation					1345:1355	the metal evaporation	1335:1355	the metal evaporation from the three nanomaterials	1335:1384	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	5	11	theme	key	946:948	arg1	role					950:953	a key role	944:953	a key role	944:953	It is shown that the matrix composition, such as chlorine and silicon, plays a key role in the evaporation of Cu and Zn at temperatures above 700 °C, while at relatively low temperatures (250 to 450 °C) the nanomaterials are most probably entrained in the flue gas independently of their chemical properties.
32155334	3	12	theme	embedded	520:527	arg1	TiO2					514:517	TiO2	514:517	TiO2	514:517	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	3	12	theme	embedded	520:527	arg1	ZnO					505:507	ZnO	505:507	ZnO	505:507	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	3	12	theme	embedded	520:527	arg1	nanomaterials					478:490	three nanomaterials	472:490	three nanomaterials	472:490	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	3	12	theme	embedded	520:527	arg1	CuO					500:502	CuO	500:502	CuO	500:502	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	4	13	theme	elemental	844:852	arg1	information					854:864	thermogravimetric and elemental information	822:864	thermogravimetric and elemental information	822:864	The latter, which combines a TGA (Thermogravimetric Analyzer) and an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer), offers the possibility to gain simultaneously thermogravimetric and elemental information.
32155334	5	14	theme	flue	1123:1126	arg1	gas					1128:1130	the flue gas	1119:1130	the flue gas independently of their chemical properties	1119:1173	It is shown that the matrix composition, such as chlorine and silicon, plays a key role in the evaporation of Cu and Zn at temperatures above 700 °C, while at relatively low temperatures (250 to 450 °C) the nanomaterials are most probably entrained in the flue gas independently of their chemical properties.
32155334	0	15	from	Treatment	41:49	arg1	Matrices					93:100	Cellulose-Based Matrices	77:100	Cellulose-Based Matrices	77:100	Evaporation of Metals during the Thermal Treatment of Oxide Nanomaterials in Cellulose-Based Matrices.
32155334	6	16	theme	Incineration	1176:1187	arg1	experiments					1189:1199	Incineration experiments	1176:1199	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues	1176:1303	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	4	17	theme	Coupled	729:735	arg1	Spectrometer					761:772	Inductively Coupled Plasma Optical Emission Spectrometer	717:772	Inductively Coupled Plasma Optical Emission Spectrometer	717:772	The latter, which combines a TGA (Thermogravimetric Analyzer) and an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer), offers the possibility to gain simultaneously thermogravimetric and elemental information.
32155334	4	17	theme	Coupled	729:735	arg1	ICP-OES					708:714	an ICP-OES	705:714	an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer)	705:773	The latter, which combines a TGA (Thermogravimetric Analyzer) and an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer), offers the possibility to gain simultaneously thermogravimetric and elemental information.
32155334	5	18	dep	450	1062:1064	arg1	to					1059:1060	to	1059:1060	to	1059:1060	It is shown that the matrix composition, such as chlorine and silicon, plays a key role in the evaporation of Cu and Zn at temperatures above 700 °C, while at relatively low temperatures (250 to 450 °C) the nanomaterials are most probably entrained in the flue gas independently of their chemical properties.
32155334	6	19	theme	metal	1339:1343	arg1	evaporation					1345:1355	the metal evaporation	1335:1355	the metal evaporation from the three nanomaterials	1335:1384	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	5	20	theme	low	1037:1039	arg1	°C					1066:1067	250 to 450 °C	1055:1067	250 to 450 °C	1055:1067	It is shown that the matrix composition, such as chlorine and silicon, plays a key role in the evaporation of Cu and Zn at temperatures above 700 °C, while at relatively low temperatures (250 to 450 °C) the nanomaterials are most probably entrained in the flue gas independently of their chemical properties.
32155334	5	20	theme	low	1037:1039	arg1	temperatures					1041:1052	relatively low temperatures	1026:1052	relatively low temperatures (250 to 450 °C)	1026:1068	It is shown that the matrix composition, such as chlorine and silicon, plays a key role in the evaporation of Cu and Zn at temperatures above 700 °C, while at relatively low temperatures (250 to 450 °C) the nanomaterials are most probably entrained in the flue gas independently of their chemical properties.
32155334	2	21	theme	physical	303:310	arg1	characteristics					312:326	their special physical characteristics	289:326	their special physical characteristics	289:326	However, because of their special physical characteristics, the fate of the thermally treated nanomaterials may differ or not from the conventional ones.
32155334	1	22	theme	life	171:174	arg1	cycle					176:180	the life cycle	167:180	the life cycle of engineered nanomaterials, which are then incinerated or stabilized before disposal	167:266	Like conventional material products, waste is the last stage of the life cycle of engineered nanomaterials, which are then incinerated or stabilized before disposal.
32155334	2	23	theme	special	295:301	arg1	characteristics					312:326	their special physical characteristics	289:326	their special physical characteristics	289:326	However, because of their special physical characteristics, the fate of the thermally treated nanomaterials may differ or not from the conventional ones.
32155334	3	24	from	matrices	532:539	arg1	embedded					520:527	embedded	520:527	embedded	520:527	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	2	25	theme	nanomaterials	363:375	arg1	fate					333:336	the fate	329:336	the fate of the thermally treated nanomaterials	329:375	However, because of their special physical characteristics, the fate of the thermally treated nanomaterials may differ or not from the conventional ones.
32155334	6	26	theme	obtained	1287:1294	arg1	residues					1296:1303	the obtained residues	1283:1303	the obtained residues	1283:1303	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	2	27	theme	conventional	404:415	arg1	ones					417:420	the conventional ones	400:420	the conventional ones	400:420	However, because of their special physical characteristics, the fate of the thermally treated nanomaterials may differ or not from the conventional ones.
32155334	0	28	theme	Metals	15:20	arg1	Evaporation					0:10	Evaporation	0:10	Evaporation of Metals during the Thermal Treatment of Oxide Nanomaterials in Cellulose-Based Matrices.	0:101	Evaporation of Metals during the Thermal Treatment of Oxide Nanomaterials in Cellulose-Based Matrices.
32155334	5	29	theme	such	908:911	arg1	composition					895:905	the matrix composition	884:905	the matrix composition	884:905	It is shown that the matrix composition, such as chlorine and silicon, plays a key role in the evaporation of Cu and Zn at temperatures above 700 °C, while at relatively low temperatures (250 to 450 °C) the nanomaterials are most probably entrained in the flue gas independently of their chemical properties.
32155334	6	30	from	quantification	1317:1330	arg1	nanomaterials					1372:1384	the three nanomaterials	1362:1384	the three nanomaterials	1362:1384	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	1	31	theme	conventional	108:119	arg1	products					130:137	conventional material products	108:137	conventional material products	108:137	Like conventional material products, waste is the last stage of the life cycle of engineered nanomaterials, which are then incinerated or stabilized before disposal.
32155334	1	32	theme	engineered	185:194	arg1	nanomaterials					196:208	engineered nanomaterials	185:208	engineered nanomaterials	185:208	Like conventional material products, waste is the last stage of the life cycle of engineered nanomaterials, which are then incinerated or stabilized before disposal.
32155334	0	33	theme	Thermal	33:39	arg1	Treatment					41:49	the Thermal Treatment	29:49	the Thermal Treatment of Oxide Nanomaterials in Cellulose-Based Matrices	29:100	Evaporation of Metals during the Thermal Treatment of Oxide Nanomaterials in Cellulose-Based Matrices.
32155334	3	34	dep	nanomaterials	478:490	arg1	nanomaterials					478:490	three nanomaterials	472:490	three nanomaterials	472:490	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	3	34	dep	nanomaterials	478:490	arg1	ZnO					505:507	ZnO	505:507	ZnO	505:507	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	3	34	dep	nanomaterials	478:490	arg1	TiO2					514:517	TiO2	514:517	TiO2	514:517	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	3	34	dep	nanomaterials	478:490	arg1	CuO					500:502	CuO	500:502	CuO	500:502	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	6	35	theme	ICP	1248:1250	arg1	furnace					1217:1223	tubular furnace	1209:1223	tubular furnace	1209:1223	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	6	35	theme	ICP	1248:1250	arg1	Spectrometry					1257:1268	ICP Mass Spectrometry	1248:1268	ICP Mass Spectrometry	1248:1268	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	3	36	theme	in-house	613:620	arg1	setup					632:636	an in-house developed setup	610:636	an in-house developed setup	610:636	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	3	37	theme	organic	552:558	arg1	compounds					574:582	organic and inorganic compounds	552:582	organic and inorganic compounds	552:582	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	1	38	theme	cycle	176:180	arg1	waste					140:144	waste	140:144	waste	140:144	Like conventional material products, waste is the last stage of the life cycle of engineered nanomaterials, which are then incinerated or stabilized before disposal.
32155334	1	38	theme	cycle	176:180	arg1	stage					158:162	the last stage	149:162	the last stage of the life cycle of engineered nanomaterials, which are then incinerated or stabilized before disposal	149:266	Like conventional material products, waste is the last stage of the life cycle of engineered nanomaterials, which are then incinerated or stabilized before disposal.
32155334	1	39	theme	nanomaterials	196:208	arg1	cycle					176:180	the life cycle	167:180	the life cycle of engineered nanomaterials, which are then incinerated or stabilized before disposal	167:266	Like conventional material products, waste is the last stage of the life cycle of engineered nanomaterials, which are then incinerated or stabilized before disposal.
32155334	0	40	from	Nanomaterials	60:72	arg1	Matrices					93:100	Cellulose-Based Matrices	77:100	Cellulose-Based Matrices	77:100	Evaporation of Metals during the Thermal Treatment of Oxide Nanomaterials in Cellulose-Based Matrices.
32155334	6	41	theme	ICP-MS	1240:1245	arg1	analysis					1271:1278	a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis	1207:1278	a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues	1207:1303	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	5	42	from	temperatures	990:1001	arg1	evaporation					962:972	the evaporation	958:972	the evaporation of Cu and Zn at temperatures above 700 °C	958:1014	It is shown that the matrix composition, such as chlorine and silicon, plays a key role in the evaporation of Cu and Zn at temperatures above 700 °C, while at relatively low temperatures (250 to 450 °C) the nanomaterials are most probably entrained in the flue gas independently of their chemical properties.
32155334	1	43	theme	material	121:128	arg1	products					130:137	conventional material products	108:137	conventional material products	108:137	Like conventional material products, waste is the last stage of the life cycle of engineered nanomaterials, which are then incinerated or stabilized before disposal.
32155334	6	44	theme	subsequent	1229:1238	arg1	ICP-MS					1240:1245	subsequent ICP-MS	1229:1245	subsequent ICP-MS	1229:1245	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	5	45	theme	Cu	977:978	arg1	evaporation					962:972	the evaporation	958:972	the evaporation of Cu and Zn at temperatures above 700 °C	958:1014	It is shown that the matrix composition, such as chlorine and silicon, plays a key role in the evaporation of Cu and Zn at temperatures above 700 °C, while at relatively low temperatures (250 to 450 °C) the nanomaterials are most probably entrained in the flue gas independently of their chemical properties.
32155334	5	46	theme	Zn	984:985	arg1	evaporation					962:972	the evaporation	958:972	the evaporation of Cu and Zn at temperatures above 700 °C	958:1014	It is shown that the matrix composition, such as chlorine and silicon, plays a key role in the evaporation of Cu and Zn at temperatures above 700 °C, while at relatively low temperatures (250 to 450 °C) the nanomaterials are most probably entrained in the flue gas independently of their chemical properties.
32155334	4	47	theme	Optical	744:750	arg1	Spectrometer					761:772	Inductively Coupled Plasma Optical Emission Spectrometer	717:772	Inductively Coupled Plasma Optical Emission Spectrometer	717:772	The latter, which combines a TGA (Thermogravimetric Analyzer) and an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer), offers the possibility to gain simultaneously thermogravimetric and elemental information.
32155334	4	47	theme	Optical	744:750	arg1	ICP-OES					708:714	an ICP-OES	705:714	an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer)	705:773	The latter, which combines a TGA (Thermogravimetric Analyzer) and an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer), offers the possibility to gain simultaneously thermogravimetric and elemental information.
32155334	4	48	theme	Thermogravimetric	673:689	arg1	TGA					668:670	a TGA	666:670	a TGA (Thermogravimetric Analyzer)	666:699	The latter, which combines a TGA (Thermogravimetric Analyzer) and an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer), offers the possibility to gain simultaneously thermogravimetric and elemental information.
32155334	4	48	theme	Thermogravimetric	673:689	arg1	Analyzer					691:698	Thermogravimetric Analyzer	673:698	Thermogravimetric Analyzer	673:698	The latter, which combines a TGA (Thermogravimetric Analyzer) and an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer), offers the possibility to gain simultaneously thermogravimetric and elemental information.
32155334	6	49	theme	furnace	1217:1223	arg1	analysis					1271:1278	a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis	1207:1278	a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues	1207:1303	Incineration experiments using a tubular furnace and subsequent ICP-MS (ICP Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evaporation from the three nanomaterials.
32155334	3	50	theme	developed	622:630	arg1	setup					632:636	an in-house developed setup	610:636	an in-house developed setup	610:636	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	4	51	theme	Plasma	737:742	arg1	Spectrometer					761:772	Inductively Coupled Plasma Optical Emission Spectrometer	717:772	Inductively Coupled Plasma Optical Emission Spectrometer	717:772	The latter, which combines a TGA (Thermogravimetric Analyzer) and an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer), offers the possibility to gain simultaneously thermogravimetric and elemental information.
32155334	4	51	theme	Plasma	737:742	arg1	ICP-OES					708:714	an ICP-OES	705:714	an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer)	705:773	The latter, which combines a TGA (Thermogravimetric Analyzer) and an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer), offers the possibility to gain simultaneously thermogravimetric and elemental information.
32155334	3	52	theme	metals	460:465	arg1	release					449:455	the thermal release	437:455	the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds	437:582	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	3	53	from	embedded	520:527	arg1	matrices					532:539	matrices	532:539	matrices containing organic and inorganic compounds	532:582	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	5	54	theme	matrix	888:893	arg1	composition					895:905	the matrix composition	884:905	the matrix composition	884:905	It is shown that the matrix composition, such as chlorine and silicon, plays a key role in the evaporation of Cu and Zn at temperatures above 700 °C, while at relatively low temperatures (250 to 450 °C) the nanomaterials are most probably entrained in the flue gas independently of their chemical properties.
32155334	0	55	theme	Nanomaterials	60:72	arg1	Treatment					41:49	the Thermal Treatment	29:49	the Thermal Treatment of Oxide Nanomaterials in Cellulose-Based Matrices	29:100	Evaporation of Metals during the Thermal Treatment of Oxide Nanomaterials in Cellulose-Based Matrices.
32155334	0	56	from	Matrices	93:100	arg1	Treatment					41:49	the Thermal Treatment	29:49	the Thermal Treatment of Oxide Nanomaterials in Cellulose-Based Matrices	29:100	Evaporation of Metals during the Thermal Treatment of Oxide Nanomaterials in Cellulose-Based Matrices.
32155334	3	57	theme	inorganic	564:572	arg1	compounds					574:582	organic and inorganic compounds	552:582	organic and inorganic compounds	552:582	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	3	58	theme	thermal	441:447	arg1	release					449:455	the thermal release	437:455	the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds	437:582	In this study the thermal release of metals from three nanomaterials, namely CuO, ZnO, and TiO2, embedded in matrices containing organic and inorganic compounds was investigated by using an in-house developed setup.
32155334	2	59	theme	treated	355:361	arg1	nanomaterials					363:375	the thermally treated nanomaterials	341:375	the thermally treated nanomaterials	341:375	However, because of their special physical characteristics, the fate of the thermally treated nanomaterials may differ or not from the conventional ones.
32155334	0	60	theme	Oxide	54:58	arg1	Nanomaterials					60:72	Oxide Nanomaterials	54:72	Oxide Nanomaterials in Cellulose-Based Matrices	54:100	Evaporation of Metals during the Thermal Treatment of Oxide Nanomaterials in Cellulose-Based Matrices.
32155334	4	61	theme	Emission	752:759	arg1	Spectrometer					761:772	Inductively Coupled Plasma Optical Emission Spectrometer	717:772	Inductively Coupled Plasma Optical Emission Spectrometer	717:772	The latter, which combines a TGA (Thermogravimetric Analyzer) and an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer), offers the possibility to gain simultaneously thermogravimetric and elemental information.
32155334	4	61	theme	Emission	752:759	arg1	ICP-OES					708:714	an ICP-OES	705:714	an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer)	705:773	The latter, which combines a TGA (Thermogravimetric Analyzer) and an ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer), offers the possibility to gain simultaneously thermogravimetric and elemental information.
32155334	5	62	theme	chemical	1155:1162	arg1	properties					1164:1173	their chemical properties	1149:1173	their chemical properties	1149:1173	It is shown that the matrix composition, such as chlorine and silicon, plays a key role in the evaporation of Cu and Zn at temperatures above 700 °C, while at relatively low temperatures (250 to 450 °C) the nanomaterials are most probably entrained in the flue gas independently of their chemical properties.
33359803	0	0	theme	djamor	107:112	arg1	mycelia					114:120	Pleurotus djamor mycelia	97:120	Pleurotus djamor mycelia	97:120	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	2	1	theme	area	474:477	arg1	composition					490:500	the peak area percentage composition	465:500	the peak area percentage composition of galacturonic acid and glucose	465:533	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	4	2	theme	kidney	884:889	arg1	injury					891:896	the kidney injury	880:896	the kidney injury	880:896	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	5	3	theme	supplements	1055:1065	arg1	kind					1039:1042	one kind	1035:1042	one kind of dietary supplements and functional foods	1035:1086	This experiment suggested that PMPS could remit CRF and other kidney injury related diseases as one kind of dietary supplements and functional foods without toxic side effects.
33359803	1	4	theme	column	270:275	arg1	chromatography					277:290	anion exchange column chromatography	255:290	anion exchange column chromatography	255:290	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	0	5	theme	Pleurotus	97:105	arg1	mycelia					114:120	Pleurotus djamor mycelia	97:120	Pleurotus djamor mycelia	97:120	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	1	6	theme	15.22	352:356	arg1	content					311:317	the phosphate content	297:317	the phosphate content of phosphorylated MPS (PMPS)	297:346	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	1	6	theme	15.22	352:356	arg1	%					364:364	15.22 ± 0.37%	352:364	15.22 ± 0.37%	352:364	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	5	7	theme	side	1102:1105	arg1	effects					1107:1113	toxic side effects	1096:1113	toxic side effects	1096:1113	This experiment suggested that PMPS could remit CRF and other kidney injury related diseases as one kind of dietary supplements and functional foods without toxic side effects.
33359803	1	8	theme	±	358:358	arg1	content					311:317	the phosphate content	297:317	the phosphate content of phosphorylated MPS (PMPS)	297:346	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	1	8	theme	±	358:358	arg1	%					364:364	15.22 ± 0.37%	352:364	15.22 ± 0.37%	352:364	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	4	9	theme	serum	755:759	arg1	staining					860:867	immunohistochemical staining	840:867	immunohistochemical staining manifested the kidney injury	840:896	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	4	9	theme	serum	755:759	arg1	observation					800:810	histopathological observation	782:810	histopathological observation	782:810	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	4	9	theme	serum	755:759	arg1	blotting					830:837	western blotting	822:837	western blotting	822:837	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	4	9	theme	serum	755:759	arg1	qRT-PCR					813:819	qRT-PCR	813:819	qRT-PCR	813:819	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	4	9	theme	serum	755:759	arg1	indices					773:779	serum biochemical indices	755:779	serum biochemical indices	755:779	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	2	10	theme	acid	518:521	arg1	structure					451:459	α-pyranose structure	440:459	α-pyranose structure	440:459	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	2	10	theme	acid	518:521	arg1	composition					490:500	the peak area percentage composition	465:500	the peak area percentage composition of galacturonic acid and glucose	465:533	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	5	11	theme	kidney	1001:1006	arg1	diseases					1023:1030	other kidney injury related diseases	995:1030	other kidney injury related diseases	995:1030	This experiment suggested that PMPS could remit CRF and other kidney injury related diseases as one kind of dietary supplements and functional foods without toxic side effects.
33359803	0	12	theme	chronic	141:147	arg1	failure					155:161	adenine-induced chronic renal failure	125:161	adenine-induced chronic renal failure mice	125:166	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	4	13	theme	immunohistochemical	840:858	arg1	staining					860:867	immunohistochemical staining	840:867	immunohistochemical staining manifested the kidney injury	840:896	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	4	13	theme	immunohistochemical	840:858	arg1	indices					773:779	serum biochemical indices	755:779	serum biochemical indices	755:779	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	0	14	theme	adenine-induced	125:139	arg1	failure					155:161	adenine-induced chronic renal failure	125:161	adenine-induced chronic renal failure mice	125:166	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	0	15	from	effect	51:56	arg1	mice					163:166	adenine-induced chronic renal failure mice	125:166	adenine-induced chronic renal failure mice	125:166	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	0	15	from	effect	51:56	arg1	mycelia					114:120	Pleurotus djamor mycelia	97:120	Pleurotus djamor mycelia	97:120	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	2	16	dep	showed	414:419	arg1	%					545:545	13.01%	540:545	13.01%	540:545	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	2	16	dep	showed	414:419	arg1	%					556:556	85.82%	551:556	85.82%	551:556	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	4	17	theme	biochemical	761:771	arg1	staining					860:867	immunohistochemical staining	840:867	immunohistochemical staining manifested the kidney injury	840:896	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	4	17	theme	biochemical	761:771	arg1	observation					800:810	histopathological observation	782:810	histopathological observation	782:810	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	4	17	theme	biochemical	761:771	arg1	blotting					830:837	western blotting	822:837	western blotting	822:837	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	4	17	theme	biochemical	761:771	arg1	qRT-PCR					813:819	qRT-PCR	813:819	qRT-PCR	813:819	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	4	17	theme	biochemical	761:771	arg1	indices					773:779	serum biochemical indices	755:779	serum biochemical indices	755:779	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	2	18	theme	galacturonic	505:516	arg1	acid					518:521	galacturonic acid	505:521	galacturonic acid	505:521	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	2	19	theme	peak	469:472	arg1	composition					490:500	the peak area percentage composition	465:500	the peak area percentage composition of galacturonic acid and glucose	465:533	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	3	20	theme	adenine-induced	683:697	arg1	mice					727:730	adenine-induced chronic renal failure (CRF) mice	683:730	adenine-induced chronic renal failure (CRF) mice	683:730	Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice.
33359803	0	21	theme	Antioxidation	0:12	arg1	effect					51:56	Antioxidation, anti-inflammation and anti-fibrosis effect	0:56	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.	0:167	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	3	22	theme	PMPS	665:668	arg1	effects					654:660	the antioxidant, anti-inflammation, anti-fibrosis effects	604:660	the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice	604:730	Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice.
33359803	1	23	theme	Pleurotus	208:216	arg1	djamor					218:223	Pleurotus djamor	208:223	Pleurotus djamor	208:223	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	1	24	theme	phosphate	301:309	arg1	content					311:317	the phosphate content	297:317	the phosphate content of phosphorylated MPS (PMPS)	297:346	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	1	24	theme	phosphate	301:309	arg1	%					364:364	15.22 ± 0.37%	352:364	15.22 ± 0.37%	352:364	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	0	25	theme	failure	155:161	arg1	mice					163:166	adenine-induced chronic renal failure mice	125:166	adenine-induced chronic renal failure mice	125:166	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	0	26	theme	anti-inflammation	15:31	arg1	effect					51:56	Antioxidation, anti-inflammation and anti-fibrosis effect	0:56	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.	0:167	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	0	27	theme	renal	149:153	arg1	failure					155:161	adenine-induced chronic renal failure	125:161	adenine-induced chronic renal failure mice	125:166	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	5	28	theme	foods	1082:1086	arg1	kind					1039:1042	one kind	1035:1042	one kind of dietary supplements and functional foods	1035:1086	This experiment suggested that PMPS could remit CRF and other kidney injury related diseases as one kind of dietary supplements and functional foods without toxic side effects.
33359803	2	29	theme	13C-NMR	398:404	arg1	results					406:412	1H and 13C-NMR results	391:412	1H and 13C-NMR results	391:412	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	3	30	from	kidney	673:678	arg1	mice					727:730	adenine-induced chronic renal failure (CRF) mice	683:730	adenine-induced chronic renal failure (CRF) mice	683:730	Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice.
33359803	3	31	theme	Animal	573:578	arg1	experiment					580:589	Animal experiment	573:589	Animal experiment	573:589	Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice.
33359803	3	32	dep	antioxidant	608:618	arg1	anti-fibrosis					640:652	anti-fibrosis	640:652	anti-fibrosis	640:652	Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice.
33359803	3	32	dep	antioxidant	608:618	arg1	anti-inflammation					621:637	anti-inflammation	621:637	anti-inflammation	621:637	Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice.
33359803	0	33	theme	anti-fibrosis	37:49	arg1	effect					51:56	Antioxidation, anti-inflammation and anti-fibrosis effect	0:56	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.	0:167	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	1	34	theme	phosphorylated	322:335	arg1	MPS					337:339	phosphorylated MPS	322:339	phosphorylated MPS (PMPS)	322:346	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	1	34	theme	phosphorylated	322:335	arg1	PMPS					342:345	PMPS	342:345	PMPS	342:345	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	2	35	theme	glucose	527:533	arg1	structure					451:459	α-pyranose structure	440:459	α-pyranose structure	440:459	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	2	35	theme	glucose	527:533	arg1	composition					490:500	the peak area percentage composition	465:500	the peak area percentage composition of galacturonic acid and glucose	465:533	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	5	36	theme	toxic	1096:1100	arg1	effects					1107:1113	toxic side effects	1096:1113	toxic side effects	1096:1113	This experiment suggested that PMPS could remit CRF and other kidney injury related diseases as one kind of dietary supplements and functional foods without toxic side effects.
33359803	2	37	theme	1H	391:392	arg1	results					406:412	1H and 13C-NMR results	391:412	1H and 13C-NMR results	391:412	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	0	38	theme	phosphorylated	61:74	arg1	polysaccharides					76:90	phosphorylated polysaccharides	61:90	phosphorylated polysaccharides from Pleurotus djamor mycelia	61:120	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	1	39	theme	MPS	337:339	arg1	content					311:317	the phosphate content	297:317	the phosphate content of phosphorylated MPS (PMPS)	297:346	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	1	39	theme	MPS	337:339	arg1	%					364:364	15.22 ± 0.37%	352:364	15.22 ± 0.37%	352:364	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	2	40	theme	percentage	479:488	arg1	composition					490:500	the peak area percentage composition	465:500	the peak area percentage composition of galacturonic acid and glucose	465:533	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	3	41	theme	failure	713:719	arg1	mice					727:730	adenine-induced chronic renal failure (CRF) mice	683:730	adenine-induced chronic renal failure (CRF) mice	683:730	Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice.
33359803	2	42	theme	α-pyranose	440:449	arg1	structure					451:459	α-pyranose structure	440:459	α-pyranose structure	440:459	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	5	43	theme	dietary	1047:1053	arg1	supplements					1055:1065	dietary supplements	1047:1065	dietary supplements	1047:1065	This experiment suggested that PMPS could remit CRF and other kidney injury related diseases as one kind of dietary supplements and functional foods without toxic side effects.
33359803	4	44	theme	western	822:828	arg1	indices					773:779	serum biochemical indices	755:779	serum biochemical indices	755:779	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	4	44	theme	western	822:828	arg1	blotting					830:837	western blotting	822:837	western blotting	822:837	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	1	45	from	djamor	218:223	arg1	MPS					198:200	MPS	198:200	MPS	198:200	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	1	45	from	djamor	218:223	arg1	polysaccharides					181:195	The mycelia polysaccharides	169:195	The mycelia polysaccharides (MPS) from Pleurotus djamor	169:223	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	3	46	from	effects	654:660	arg1	kidney					673:678	kidney	673:678	kidney in adenine-induced chronic renal failure (CRF) mice	673:730	Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice.
33359803	5	47	theme	functional	1071:1080	arg1	foods					1082:1086	functional foods	1071:1086	functional foods	1071:1086	This experiment suggested that PMPS could remit CRF and other kidney injury related diseases as one kind of dietary supplements and functional foods without toxic side effects.
33359803	4	48	theme	PMPS	919:922	arg1	interventions					924:936	PMPS interventions	919:936	PMPS interventions	919:936	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	4	49	theme	histopathological	782:798	arg1	observation					800:810	histopathological observation	782:810	histopathological observation	782:810	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	4	49	theme	histopathological	782:798	arg1	indices					773:779	serum biochemical indices	755:779	serum biochemical indices	755:779	All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions.
33359803	3	50	theme	antioxidant	608:618	arg1	effects					654:660	the antioxidant, anti-inflammation, anti-fibrosis effects	604:660	the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice	604:730	Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice.
33359803	5	51	theme	other	995:999	arg1	diseases					1023:1030	other kidney injury related diseases	995:1030	other kidney injury related diseases	995:1030	This experiment suggested that PMPS could remit CRF and other kidney injury related diseases as one kind of dietary supplements and functional foods without toxic side effects.
33359803	5	52	theme	injury	1008:1013	arg1	diseases					1023:1030	other kidney injury related diseases	995:1030	other kidney injury related diseases	995:1030	This experiment suggested that PMPS could remit CRF and other kidney injury related diseases as one kind of dietary supplements and functional foods without toxic side effects.
33359803	0	53	from	mycelia	114:120	arg1	effect					51:56	Antioxidation, anti-inflammation and anti-fibrosis effect	0:56	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.	0:167	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	0	53	from	mycelia	114:120	arg1	polysaccharides					76:90	phosphorylated polysaccharides	61:90	phosphorylated polysaccharides from Pleurotus djamor mycelia	61:120	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	5	54	theme	related	1015:1021	arg1	diseases					1023:1030	other kidney injury related diseases	995:1030	other kidney injury related diseases	995:1030	This experiment suggested that PMPS could remit CRF and other kidney injury related diseases as one kind of dietary supplements and functional foods without toxic side effects.
33359803	2	55	theme	FT-IR	367:371	arg1	spectra					373:379	FT-IR spectra	367:379	FT-IR spectra	367:379	FT-IR spectra, HPLC and 1H and 13C-NMR results showed the PMPS contained α-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively.
33359803	1	56	theme	anion	255:259	arg1	chromatography					277:290	anion exchange column chromatography	255:290	anion exchange column chromatography	255:290	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	0	57	theme	polysaccharides	76:90	arg1	effect					51:56	Antioxidation, anti-inflammation and anti-fibrosis effect	0:56	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.	0:167	Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.
33359803	3	58	theme	chronic	699:705	arg1	CRF					722:724	CRF	722:724	CRF	722:724	Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice.
33359803	3	58	theme	chronic	699:705	arg1	failure					713:719	chronic renal failure	699:719	adenine-induced chronic renal failure (CRF) mice	683:730	Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice.
33359803	3	59	theme	renal	707:711	arg1	CRF					722:724	CRF	722:724	CRF	722:724	Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice.
33359803	3	59	theme	renal	707:711	arg1	failure					713:719	chronic renal failure	699:719	adenine-induced chronic renal failure (CRF) mice	683:730	Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice.
33359803	1	60	theme	mycelia	173:179	arg1	MPS					198:200	MPS	198:200	MPS	198:200	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	1	60	theme	mycelia	173:179	arg1	polysaccharides					181:195	The mycelia polysaccharides	169:195	The mycelia polysaccharides (MPS) from Pleurotus djamor	169:223	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33359803	1	61	theme	exchange	261:268	arg1	chromatography					277:290	anion exchange column chromatography	255:290	anion exchange column chromatography	255:290	The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22 ± 0.37%.
33837937	0	0	theme	poly	89:92	arg1	/chitosan					139:147	decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan	79:147	decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan	79:147	Effective removal of doxycycline from aqueous solution using CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan.
33837937	6	1	theme	adsorption	1266:1275	arg1	process					1277:1283	adsorption process	1266:1283	adsorption process	1266:1283	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	6	2	theme	process	1277:1283	arg1	nature					1256:1261	the spontaneous and endothermic nature	1224:1261	the spontaneous and endothermic nature of adsorption process	1224:1283	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	6	3	theme	ΔG°	1122:1124	arg1	values					1112:1117	The values	1108:1117	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1)	1108:1209	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	0	4	theme	decorated	79:87	arg1	poly					89:92	decorated poly	79:92	decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan	79:147	Effective removal of doxycycline from aqueous solution using CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan.
33837937	0	4	theme	decorated	79:87	arg1	acid					134:137	2-acrylamido-2-methyl-1-propanesulfonic acid	94:137	2-acrylamido-2-methyl-1-propanesulfonic acid	94:137	Effective removal of doxycycline from aqueous solution using CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan.
33837937	1	5	theme	present	175:181	arg1	study					183:187	the present study	171:187	the present study	171:187	The primary focus of the present study was to synthesize CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan to explore its potential for uptake of doxycycline (DXN) from water.
33837937	0	6	theme	2-acrylamido-2-methyl-1-propanesulfonic	94:132	arg1	poly					89:92	decorated poly	79:92	decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan	79:147	Effective removal of doxycycline from aqueous solution using CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan.
33837937	0	6	theme	2-acrylamido-2-methyl-1-propanesulfonic	94:132	arg1	acid					134:137	2-acrylamido-2-methyl-1-propanesulfonic acid	94:137	2-acrylamido-2-methyl-1-propanesulfonic acid	94:137	Effective removal of doxycycline from aqueous solution using CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan.
33837937	3	7	theme	DXN	773:775	arg1	variables					698:706	the process variables	686:706	the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency	686:821	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	7	theme	DXN	773:775	arg1	pH					709:710	pH	709:710	pH	709:710	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	7	theme	DXN	773:775	arg1	dosage					723:728	adsorbent dosage	713:728	adsorbent dosage	713:728	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	7	theme	DXN	773:775	arg1	time					739:742	contact time	731:742	contact time	731:742	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	7	theme	DXN	773:775	arg1	concentration					756:768	initial concentration	748:768	initial concentration	748:768	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	7	8	theme	material	1369:1376	arg1	reusability					1331:1341	the reusability	1327:1341	the reusability of the prepared composite material for DXN uptake up to six cycles	1327:1408	The adsorption/desorption study revealed the reusability of the prepared composite material for DXN uptake up to six cycles.
33837937	4	9	theme	DXN	839:841	arg1	removal					828:834	The removal	824:834	The removal of DXN	824:841	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	7	10	theme	composite	1359:1367	arg1	material					1369:1376	the prepared composite material	1346:1376	the prepared composite material for DXN uptake	1346:1391	The adsorption/desorption study revealed the reusability of the prepared composite material for DXN uptake up to six cycles.
33837937	3	11	theme	highest	796:802	arg1	efficiency					812:821	the highest removal efficiency	792:821	the highest removal efficiency	792:821	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	6	12	theme	endothermic	1244:1254	arg1	nature					1256:1261	the spontaneous and endothermic nature	1224:1261	the spontaneous and endothermic nature of adsorption process	1224:1283	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	3	13	theme	response	635:642	arg1	methodology					652:662	response surface methodology	635:662	response surface methodology	635:662	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	0	14	from	solution	46:53	arg1	removal					10:16	Effective removal	0:16	Effective removal of doxycycline from aqueous solution using CuO	0:63	Effective removal of doxycycline from aqueous solution using CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan.
33837937	4	15	theme	pH	899:900	arg1	conditions					885:894	the optimum conditions	873:894	the optimum conditions of pH 7.0	873:904	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	7	16	theme	adsorption/desorption	1290:1310	arg1	study					1312:1316	The adsorption/desorption study	1286:1316	The adsorption/desorption study	1286:1316	The adsorption/desorption study revealed the reusability of the prepared composite material for DXN uptake up to six cycles.
33837937	3	17	theme	composite	612:620	arg1	design					622:627	Central composite design	604:627	Central composite design under response surface methodology	604:662	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	1	18	theme	study	183:187	arg1	focus					162:166	The primary focus	150:166	The primary focus of the present study	150:187	The primary focus of the present study was to synthesize CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan to explore its potential for uptake of doxycycline (DXN) from water.
33837937	1	19	from	water	357:361	arg1	uptake					324:329	uptake	324:329	uptake of doxycycline (DXN) from water	324:361	The primary focus of the present study was to synthesize CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan to explore its potential for uptake of doxycycline (DXN) from water.
33837937	2	20	theme	X-ray	524:528	arg1	diffraction					530:540	X-ray diffraction	524:540	X-ray diffraction	524:540	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	0	21	theme	Effective	0:8	arg1	removal					10:16	Effective removal	0:16	Effective removal of doxycycline from aqueous solution using CuO	0:63	Effective removal of doxycycline from aqueous solution using CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan.
33837937	2	22	theme	dispersive	493:502	arg1	spectroscopy					510:521	energy dispersive X-ray spectroscopy	486:521	energy dispersive X-ray spectroscopy	486:521	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	4	23	theme	L-1	1002:1004	arg1	concentration					979:991	initial concentration	971:991	initial concentration of 50 mg L-1	971:1004	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	4	23	theme	L-1	1002:1004	arg1	time					921:924	time	921:924	time of 70 min	921:934	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	4	23	theme	L-1	1002:1004	arg1	dose					947:950	adsorbent dose	937:950	adsorbent dose of 20 mg/25 mL	937:965	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	4	24	theme	mg	999:1000	arg1	L-1					1002:1004	50 mg L-1	996:1004	50 mg L-1	996:1004	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	3	25	theme	removal	804:810	arg1	efficiency					812:821	the highest removal efficiency	792:821	the highest removal efficiency	792:821	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	2	26	theme	energy	486:491	arg1	spectroscopy					510:521	energy dispersive X-ray spectroscopy	486:521	energy dispersive X-ray spectroscopy	486:521	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	6	27	theme	ΔH°	1159:1161	arg1	values					1112:1117	The values	1108:1117	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1)	1108:1209	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	3	28	dep	variables	698:706	arg1	variables					698:706	the process variables	686:706	the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency	686:821	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	28	dep	variables	698:706	arg1	pH					709:710	pH	709:710	pH	709:710	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	28	dep	variables	698:706	arg1	dosage					723:728	adsorbent dosage	713:728	adsorbent dosage	713:728	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	28	dep	variables	698:706	arg1	time					739:742	contact time	731:742	contact time	731:742	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	28	dep	variables	698:706	arg1	concentration					756:768	initial concentration	748:768	initial concentration	748:768	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	0	29	theme	doxycycline	21:31	arg1	removal					10:16	Effective removal	0:16	Effective removal of doxycycline from aqueous solution using CuO	0:63	Effective removal of doxycycline from aqueous solution using CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan.
33837937	6	30	theme	J	1198:1198	arg1	K-1					1206:1208	283.382 J mol-1 K-1	1190:1208	283.382 J mol-1 K-1	1190:1208	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	6	30	theme	J	1198:1198	arg1	ΔS°					1185:1187	ΔS°	1185:1187	ΔS° (283.382 J mol-1 K-1)	1185:1209	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	3	31	theme	surface	644:650	arg1	methodology					652:662	response surface methodology	635:662	response surface methodology	635:662	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	7	32	theme	DXN	1382:1384	arg1	uptake					1386:1391	DXN uptake	1382:1391	DXN uptake	1382:1391	The adsorption/desorption study revealed the reusability of the prepared composite material for DXN uptake up to six cycles.
33837937	2	33	theme	electron	461:468	arg1	microscopy					470:479	scanning electron microscopy	452:479	scanning electron microscopy	452:479	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	2	33	theme	electron	461:468	arg1	spectroscopy					438:449	spectroscopy	438:449	spectroscopy	438:449	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	6	34	theme	kJ	1171:1172	arg1	ΔH°					1159:1161	ΔH°	1159:1161	ΔH° (56.768 kJ mol-1)	1159:1179	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	6	34	theme	kJ	1171:1172	arg1	mol-1					1174:1178	56.768 kJ mol-1	1164:1178	56.768 kJ mol-1	1164:1178	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	2	35	theme	composite	368:376	arg1	material					378:385	The composite material	364:385	The composite material	364:385	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	2	36	theme	scanning	452:459	arg1	microscopy					470:479	scanning electron microscopy	452:479	scanning electron microscopy	452:479	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	2	36	theme	scanning	452:459	arg1	spectroscopy					438:449	spectroscopy	438:449	spectroscopy	438:449	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	0	37	theme	aqueous	38:44	arg1	solution					46:53	aqueous solution	38:53	aqueous solution using CuO	38:63	Effective removal of doxycycline from aqueous solution using CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan.
33837937	4	38	theme	mL	964:965	arg1	concentration					979:991	initial concentration	971:991	initial concentration of 50 mg L-1	971:1004	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	4	38	theme	mL	964:965	arg1	time					921:924	time	921:924	time of 70 min	921:934	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	4	38	theme	mL	964:965	arg1	dose					947:950	adsorbent dose	937:950	adsorbent dose of 20 mg/25 mL	937:965	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	3	39	theme	contact	731:737	arg1	variables					698:706	the process variables	686:706	the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency	686:821	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	39	theme	contact	731:737	arg1	time					739:742	contact time	731:742	contact time	731:742	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	5	40	theme	pseudo-second-order	1033:1051	arg1	models					1061:1066	pseudo-second-order kinetic models	1033:1066	pseudo-second-order kinetic models	1033:1066	The Langmuir isotherm and pseudo-second-order kinetic models fitted best with the experimental data.
33837937	1	41	theme	decorated	225:233	arg1	acid					280:283	2-acrylamido-2-methyl-1-propanesulfonic acid	240:283	2-acrylamido-2-methyl-1-propanesulfonic acid	240:283	The primary focus of the present study was to synthesize CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan to explore its potential for uptake of doxycycline (DXN) from water.
33837937	1	41	theme	decorated	225:233	arg1	poly					235:238	decorated poly	225:238	CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)	207:284	The primary focus of the present study was to synthesize CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan to explore its potential for uptake of doxycycline (DXN) from water.
33837937	6	42	theme	spontaneous	1228:1238	arg1	nature					1256:1261	the spontaneous and endothermic nature	1224:1261	the spontaneous and endothermic nature of adsorption process	1224:1283	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	1	43	theme	doxycycline	334:344	arg1	uptake					324:329	uptake	324:329	uptake of doxycycline (DXN) from water	324:361	The primary focus of the present study was to synthesize CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan to explore its potential for uptake of doxycycline (DXN) from water.
33837937	3	44	theme	adsorbent	713:721	arg1	dosage					723:728	adsorbent dosage	713:728	adsorbent dosage	713:728	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	44	theme	adsorbent	713:721	arg1	variables					698:706	the process variables	686:706	the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency	686:821	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	45	theme	process	690:696	arg1	time					739:742	contact time	731:742	contact time	731:742	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	45	theme	process	690:696	arg1	pH					709:710	pH	709:710	pH	709:710	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	45	theme	process	690:696	arg1	dosage					723:728	adsorbent dosage	713:728	adsorbent dosage	713:728	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	45	theme	process	690:696	arg1	variables					698:706	the process variables	686:706	the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency	686:821	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	45	theme	process	690:696	arg1	concentration					756:768	initial concentration	748:768	initial concentration	748:768	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	2	46	theme	thermal	586:592	arg1	analysis					594:601	thermogravimetric analysis-differential thermal analysis	546:601	thermogravimetric analysis-differential thermal analysis	546:601	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	4	47	theme	initial	971:977	arg1	concentration					979:991	initial concentration	971:991	initial concentration of 50 mg L-1	971:1004	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	4	48	theme	50	996:997	arg1	mg					999:1000	mg	999:1000	mg	999:1000	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	6	49	theme	mol-1	1200:1204	arg1	K-1					1206:1208	283.382 J mol-1 K-1	1190:1208	283.382 J mol-1 K-1	1190:1208	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	6	49	theme	mol-1	1200:1204	arg1	ΔS°					1185:1187	ΔS°	1185:1187	ΔS° (283.382 J mol-1 K-1)	1185:1209	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	2	50	theme	X-ray	504:508	arg1	spectroscopy					510:521	energy dispersive X-ray spectroscopy	486:521	energy dispersive X-ray spectroscopy	486:521	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	4	51	theme	min	932:934	arg1	concentration					979:991	initial concentration	971:991	initial concentration of 50 mg L-1	971:1004	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	4	51	theme	min	932:934	arg1	time					921:924	time	921:924	time of 70 min	921:934	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	4	51	theme	min	932:934	arg1	dose					947:950	adsorbent dose	937:950	adsorbent dose of 20 mg/25 mL	937:965	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	3	52	theme	initial	748:754	arg1	variables					698:706	the process variables	686:706	the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency	686:821	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	3	52	theme	initial	748:754	arg1	concentration					756:768	initial concentration	748:768	initial concentration	748:768	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
33837937	4	53	theme	optimum	877:883	arg1	conditions					885:894	the optimum conditions	873:894	the optimum conditions of pH 7.0	873:904	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	6	54	theme	kJ	1148:1149	arg1	ΔG°					1122:1124	ΔG°	1122:1124	ΔG° (- 29.159 to - 31.997 kJ mol-1)	1122:1156	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	6	54	theme	kJ	1148:1149	arg1	mol-1					1151:1155	- 29.159 to - 31.997 kJ mol-1	1127:1155	- 29.159 to - 31.997 kJ mol-1	1127:1155	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	2	55	dep	transform	419:427	arg1	infrared					429:436	infrared	429:436	transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis	419:601	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	6	56	dep	- 31.997	1139:1146	arg1	to					1136:1137	to	1136:1137	to	1136:1137	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	2	57	dep	Fourier	411:417	arg1	transform					419:427	transform	419:427	transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis	419:601	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	5	58	theme	kinetic	1053:1059	arg1	models					1061:1066	pseudo-second-order kinetic models	1033:1066	pseudo-second-order kinetic models	1033:1066	The Langmuir isotherm and pseudo-second-order kinetic models fitted best with the experimental data.
33837937	4	59	theme	adsorbent	937:945	arg1	dose					947:950	adsorbent dose	937:950	adsorbent dose of 20 mg/25 mL	937:965	The removal of DXN reached 98.84% at 303 K under the optimum conditions of pH 7.0, equilibrating time of 70 min, adsorbent dose of 20 mg/25 mL and initial concentration of 50 mg L-1.
33837937	5	60	theme	Langmuir	1011:1018	arg1	isotherm					1020:1027	The Langmuir isotherm	1007:1027	The Langmuir isotherm	1007:1027	The Langmuir isotherm and pseudo-second-order kinetic models fitted best with the experimental data.
33837937	1	61	theme	primary	154:160	arg1	focus					162:166	The primary focus	150:166	The primary focus of the present study	150:187	The primary focus of the present study was to synthesize CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan to explore its potential for uptake of doxycycline (DXN) from water.
33837937	1	62	theme	2-acrylamido-2-methyl-1-propanesulfonic	240:278	arg1	acid					280:283	2-acrylamido-2-methyl-1-propanesulfonic acid	240:283	2-acrylamido-2-methyl-1-propanesulfonic acid	240:283	The primary focus of the present study was to synthesize CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan to explore its potential for uptake of doxycycline (DXN) from water.
33837937	1	62	theme	2-acrylamido-2-methyl-1-propanesulfonic	240:278	arg1	poly					235:238	decorated poly	225:238	CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)	207:284	The primary focus of the present study was to synthesize CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan to explore its potential for uptake of doxycycline (DXN) from water.
33837937	2	63	theme	analysis-differential	564:584	arg1	analysis					594:601	thermogravimetric analysis-differential thermal analysis	546:601	thermogravimetric analysis-differential thermal analysis	546:601	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	5	64	theme	experimental	1089:1100	arg1	data					1102:1105	the experimental data	1085:1105	the experimental data	1085:1105	The Langmuir isotherm and pseudo-second-order kinetic models fitted best with the experimental data.
33837937	6	65	theme	ΔS°	1185:1187	arg1	values					1112:1117	The values	1108:1117	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1)	1108:1209	The values of ΔG° (- 29.159 to - 31.997 kJ mol-1), ΔH° (56.768 kJ mol-1) and ΔS° (283.382 J mol-1 K-1) demonstrated the spontaneous and endothermic nature of adsorption process.
33837937	1	66	theme	CuO	207:209	arg1	nanoparticles					211:223	CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)	207:284	CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)	207:284	The primary focus of the present study was to synthesize CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan to explore its potential for uptake of doxycycline (DXN) from water.
33837937	2	67	theme	thermogravimetric	546:562	arg1	analysis					594:601	thermogravimetric analysis-differential thermal analysis	546:601	thermogravimetric analysis-differential thermal analysis	546:601	The composite material was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy, X-ray diffraction and thermogravimetric analysis-differential thermal analysis.
33837937	7	68	theme	prepared	1350:1357	arg1	material					1369:1376	the prepared composite material	1346:1376	the prepared composite material for DXN uptake	1346:1391	The adsorption/desorption study revealed the reusability of the prepared composite material for DXN uptake up to six cycles.
33837937	1	69	dep	nanoparticles	211:223	arg1	acid					280:283	2-acrylamido-2-methyl-1-propanesulfonic acid	240:283	2-acrylamido-2-methyl-1-propanesulfonic acid	240:283	The primary focus of the present study was to synthesize CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan to explore its potential for uptake of doxycycline (DXN) from water.
33837937	1	69	dep	nanoparticles	211:223	arg1	poly					235:238	decorated poly	225:238	CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)	207:284	The primary focus of the present study was to synthesize CuO nanoparticles decorated poly(2-acrylamido-2-methyl-1-propanesulfonic acid)/chitosan to explore its potential for uptake of doxycycline (DXN) from water.
33837937	3	70	theme	Central	604:610	arg1	design					622:627	Central composite design	604:627	Central composite design under response surface methodology	604:662	Central composite design under response surface methodology was opted to optimize the process variables (pH, adsorbent dosage, contact time and initial concentration of DXN) for obtaining the highest removal efficiency.
34044118	0	0	theme	wound	85:89	arg1	healing					91:97	wound healing	85:97	wound healing	85:97	Design and characterization of highly porous curcumin loaded freeze-dried wafers for wound healing.
34044118	6	1	theme	%	563:563	arg1	content					570:576	% Drug content	563:576	% Drug content	563:576	% Drug content, in-vitro release and % water uptake tests were conducted to characterize the fabricated wafers.
34044118	7	2	theme	scanning	758:765	arg1	microscopy					776:785	scanning electron microscopy	758:785	scanning electron microscopy	758:785	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	7	3	dep	Fourier	849:855	arg1	transform					857:865	transform	857:865	transform infrared spectroscopy	857:887	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	9	4	theme	bacterial	1258:1266	arg1	inhibition					1275:1284	bacterial growth inhibition	1258:1284	bacterial growth inhibition against Staphylococcus epidermidis and Staphylococcus aureus (MRSA) bacteria	1258:1361	Microbiological assay revealed the superiority of the selected curcumin wafers versus free curcumin in bacterial growth inhibition against Staphylococcus epidermidis and Staphylococcus aureus (MRSA) bacteria.
34044118	1	5	theme	beneficial	146:155	arg1	effects					157:163	the beneficial effects	142:163	the beneficial effects of topical curcumin loaded freeze-dried wafers in wound healing	142:227	The goal of this research was to evaluate the beneficial effects of topical curcumin loaded freeze-dried wafers in wound healing.
34044118	7	6	theme	cross-linked	927:938	arg1	wafers					940:945	the optimized cross-linked wafers	913:945	the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies	913:1011	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	7	7	theme	electron	767:774	arg1	microscopy					776:785	scanning electron microscopy	758:785	scanning electron microscopy	758:785	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	8	8	theme	water	1074:1078	arg1	capabilities					1087:1098	high water uptake capabilities	1069:1098	high water uptake capabilities	1069:1098	The results showed that the optimized wafers possessed high water uptake capabilities while entertaining very high porosity levels (86-89%).
34044118	8	9	theme	porosity	1129:1136	arg1	levels					1138:1143	very high porosity levels	1119:1143	very high porosity levels (86-89%)	1119:1152	The results showed that the optimized wafers possessed high water uptake capabilities while entertaining very high porosity levels (86-89%).
34044118	8	9	theme	porosity	1129:1136	arg1	%					1151:1151	86-89%	1146:1151	86-89%	1146:1151	The results showed that the optimized wafers possessed high water uptake capabilities while entertaining very high porosity levels (86-89%).
34044118	8	10	theme	optimized	1042:1050	arg1	wafers					1052:1057	the optimized wafers	1038:1057	the optimized wafers	1038:1057	The results showed that the optimized wafers possessed high water uptake capabilities while entertaining very high porosity levels (86-89%).
34044118	9	11	dep	epidermidis	1309:1319	arg1	bacteria					1354:1361	bacteria	1354:1361	bacteria	1354:1361	Microbiological assay revealed the superiority of the selected curcumin wafers versus free curcumin in bacterial growth inhibition against Staphylococcus epidermidis and Staphylococcus aureus (MRSA) bacteria.
34044118	12	12	dep	wafers	1642:1647	arg1	offered					1649:1655	offered	1649:1655	wafers offered a promising solution in the field of wound healing	1642:1706	To conclude, the obtained findings revealed that curcumin wafers offered a promising solution in the field of wound healing.
34044118	8	13	theme	high	1124:1127	arg1	levels					1138:1143	very high porosity levels	1119:1143	very high porosity levels (86-89%)	1119:1152	The results showed that the optimized wafers possessed high water uptake capabilities while entertaining very high porosity levels (86-89%).
34044118	8	13	theme	high	1124:1127	arg1	%					1151:1151	86-89%	1146:1151	86-89%	1146:1151	The results showed that the optimized wafers possessed high water uptake capabilities while entertaining very high porosity levels (86-89%).
34044118	8	14	theme	high	1069:1072	arg1	capabilities					1087:1098	high water uptake capabilities	1069:1098	high water uptake capabilities	1069:1098	The results showed that the optimized wafers possessed high water uptake capabilities while entertaining very high porosity levels (86-89%).
34044118	2	15	theme	chitosan	282:289	arg1	cross-linking					265:277	cross-linking	265:277	cross-linking of chitosan with beta glycerophosphate under magnetic stirring	265:340	Curcumin wafers were fabricated by cross-linking of chitosan with beta glycerophosphate under magnetic stirring.
34044118	10	16	theme	wafers	1419:1424	arg1	effects					1386:1392	The anti-inflammatory effects	1364:1392	The anti-inflammatory effects of the selected curcumin wafers	1364:1424	The anti-inflammatory effects of the selected curcumin wafers were evaluated against pro-inflammatory cytokines.
34044118	10	17	theme	selected	1401:1408	arg1	wafers					1419:1424	the selected curcumin wafers	1397:1424	the selected curcumin wafers	1397:1424	The anti-inflammatory effects of the selected curcumin wafers were evaluated against pro-inflammatory cytokines.
34044118	7	18	theme	optimized	917:925	arg1	wafers					940:945	the optimized cross-linked wafers	913:945	the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies	913:1011	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	9	19	from	curcumin	1246:1253	arg1	inhibition					1275:1284	bacterial growth inhibition	1258:1284	bacterial growth inhibition against Staphylococcus epidermidis and Staphylococcus aureus (MRSA) bacteria	1258:1361	Microbiological assay revealed the superiority of the selected curcumin wafers versus free curcumin in bacterial growth inhibition against Staphylococcus epidermidis and Staphylococcus aureus (MRSA) bacteria.
34044118	11	20	theme	free	1540:1543	arg1	curcumin					1545:1552	free curcumin	1540:1552	free curcumin	1540:1552	The results suggested that they were significantly better than free curcumin in lowering cytokines levels.
34044118	8	21	contain	possessed	1059:1067	arg2	capabilities					1087:1098	high water uptake capabilities	1069:1098	high water uptake capabilities	1069:1098	The results showed that the optimized wafers possessed high water uptake capabilities while entertaining very high porosity levels (86-89%).
34044118	8	21	contain	possessed	1059:1067	arg1	wafers					1052:1057	the optimized wafers	1038:1057	the optimized wafers	1038:1057	The results showed that the optimized wafers possessed high water uptake capabilities while entertaining very high porosity levels (86-89%).
34044118	8	22	theme	uptake	1080:1085	arg1	capabilities					1087:1098	high water uptake capabilities	1069:1098	high water uptake capabilities	1069:1098	The results showed that the optimized wafers possessed high water uptake capabilities while entertaining very high porosity levels (86-89%).
34044118	6	23	theme	uptake	608:613	arg1	tests					615:619	% Drug content, in-vitro release and % water uptake tests	563:619	% Drug content, in-vitro release and % water uptake tests	563:619	% Drug content, in-vitro release and % water uptake tests were conducted to characterize the fabricated wafers.
34044118	9	24	theme	Microbiological	1155:1169	arg1	assay					1171:1175	Microbiological assay	1155:1175	Microbiological assay	1155:1175	Microbiological assay revealed the superiority of the selected curcumin wafers versus free curcumin in bacterial growth inhibition against Staphylococcus epidermidis and Staphylococcus aureus (MRSA) bacteria.
34044118	3	25	theme	sodium	393:398	arg1	hyaluronate					400:410	sodium hyaluronate	393:410	sodium hyaluronate	393:410	Composite wafers were prepared by the addition of sodium hyaluronate.
34044118	12	26	from	solution	1669:1676	arg1	field					1685:1689	the field	1681:1689	the field of wound healing	1681:1706	To conclude, the obtained findings revealed that curcumin wafers offered a promising solution in the field of wound healing.
34044118	6	27	theme	content	570:576	arg1	tests					615:619	% Drug content, in-vitro release and % water uptake tests	563:619	% Drug content, in-vitro release and % water uptake tests	563:619	% Drug content, in-vitro release and % water uptake tests were conducted to characterize the fabricated wafers.
34044118	2	28	theme	magnetic	324:331	arg1	stirring					333:340	magnetic stirring	324:340	magnetic stirring	324:340	Curcumin wafers were fabricated by cross-linking of chitosan with beta glycerophosphate under magnetic stirring.
34044118	11	29	theme	cytokines	1566:1574	arg1	levels					1576:1581	cytokines levels	1566:1581	cytokines levels	1566:1581	The results suggested that they were significantly better than free curcumin in lowering cytokines levels.
34044118	1	30	theme	topical	168:174	arg1	wafers					205:210	topical curcumin loaded freeze-dried wafers	168:210	topical curcumin loaded freeze-dried wafers	168:210	The goal of this research was to evaluate the beneficial effects of topical curcumin loaded freeze-dried wafers in wound healing.
34044118	3	31	theme	hyaluronate	400:410	arg1	addition					381:388	the addition	377:388	the addition of sodium hyaluronate	377:410	Composite wafers were prepared by the addition of sodium hyaluronate.
34044118	7	32	theme	cytotoxicity	992:1003	arg1	studies					1005:1011	cytotoxicity studies	992:1011	cytotoxicity studies	992:1011	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	1	33	theme	curcumin	176:183	arg1	wafers					205:210	topical curcumin loaded freeze-dried wafers	168:210	topical curcumin loaded freeze-dried wafers	168:210	The goal of this research was to evaluate the beneficial effects of topical curcumin loaded freeze-dried wafers in wound healing.
34044118	6	34	theme	water	602:606	arg1	uptake					608:613	% water uptake	600:613	% water uptake	600:613	% Drug content, in-vitro release and % water uptake tests were conducted to characterize the fabricated wafers.
34044118	7	35	theme	infrared	867:874	arg1	spectroscopy					876:887	infrared spectroscopy	867:887	infrared spectroscopy	867:887	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	2	36	theme	glycerophosphate	301:316	arg1	beta					296:299	beta glycerophosphate	296:316	beta glycerophosphate under magnetic stirring	296:340	Curcumin wafers were fabricated by cross-linking of chitosan with beta glycerophosphate under magnetic stirring.
34044118	1	37	theme	loaded	185:190	arg1	wafers					205:210	topical curcumin loaded freeze-dried wafers	168:210	topical curcumin loaded freeze-dried wafers	168:210	The goal of this research was to evaluate the beneficial effects of topical curcumin loaded freeze-dried wafers in wound healing.
34044118	6	38	theme	%	600:600	arg1	uptake					608:613	% water uptake	600:613	% water uptake	600:613	% Drug content, in-vitro release and % water uptake tests were conducted to characterize the fabricated wafers.
34044118	10	39	theme	pro-inflammatory	1449:1464	arg1	cytokines					1466:1474	pro-inflammatory cytokines	1449:1474	pro-inflammatory cytokines	1449:1474	The anti-inflammatory effects of the selected curcumin wafers were evaluated against pro-inflammatory cytokines.
34044118	7	40	link	cross-linked	927:938	arg1	wafers					940:945	the optimized cross-linked wafers	913:945	the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies	913:1011	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	5	41	theme	naked	501:505	arg1	eye					507:509	naked eye	501:509	naked eye	501:509	The resulted wafers were examined by naked eye and their dimensions were measured using a caliper.
34044118	1	42	theme	freeze-dried	192:203	arg1	wafers					205:210	topical curcumin loaded freeze-dried wafers	168:210	topical curcumin loaded freeze-dried wafers	168:210	The goal of this research was to evaluate the beneficial effects of topical curcumin loaded freeze-dried wafers in wound healing.
34044118	0	43	theme	porous	38:43	arg1	curcumin					45:52	highly porous curcumin	31:52	highly porous curcumin	31:52	Design and characterization of highly porous curcumin loaded freeze-dried wafers for wound healing.
34044118	7	44	theme	morphological	726:738	arg1	examination					740:750	morphological examination	726:750	morphological examination using scanning electron microscopy	726:785	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	7	44	theme	morphological	726:738	arg1	testing					684:690	Porosity testing	675:690	Porosity testing	675:690	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	2	45	theme	Curcumin	230:237	arg1	wafers					239:244	Curcumin wafers	230:244	Curcumin wafers	230:244	Curcumin wafers were fabricated by cross-linking of chitosan with beta glycerophosphate under magnetic stirring.
34044118	10	46	theme	curcumin	1410:1417	arg1	wafers					1419:1424	the selected curcumin wafers	1397:1424	the selected curcumin wafers	1397:1424	The anti-inflammatory effects of the selected curcumin wafers were evaluated against pro-inflammatory cytokines.
34044118	1	47	theme	wafers	205:210	arg1	effects					157:163	the beneficial effects	142:163	the beneficial effects of topical curcumin loaded freeze-dried wafers in wound healing	142:227	The goal of this research was to evaluate the beneficial effects of topical curcumin loaded freeze-dried wafers in wound healing.
34044118	6	48	theme	release	588:594	arg1	tests					615:619	% Drug content, in-vitro release and % water uptake tests	563:619	% Drug content, in-vitro release and % water uptake tests	563:619	% Drug content, in-vitro release and % water uptake tests were conducted to characterize the fabricated wafers.
34044118	7	49	theme	scanning	824:831	arg1	calorimetry					833:843	differential scanning calorimetry	811:843	differential scanning calorimetry	811:843	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	12	50	theme	promising	1659:1667	arg1	solution					1669:1676	a promising solution	1657:1676	a promising solution in the field of wound healing	1657:1706	To conclude, the obtained findings revealed that curcumin wafers offered a promising solution in the field of wound healing.
34044118	7	51	theme	mechanical	705:714	arg1	behavior					716:723	compressive mechanical behavior	693:723	compressive mechanical behavior	693:723	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	7	51	theme	mechanical	705:714	arg1	testing					684:690	Porosity testing	675:690	Porosity testing	675:690	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	6	52	theme	in-vitro	579:586	arg1	release					588:594	in-vitro release	579:594	in-vitro release	579:594	% Drug content, in-vitro release and % water uptake tests were conducted to characterize the fabricated wafers.
34044118	6	53	theme	Drug	565:568	arg1	content					570:576	% Drug content	563:576	% Drug content	563:576	% Drug content, in-vitro release and % water uptake tests were conducted to characterize the fabricated wafers.
34044118	9	54	theme	selected	1209:1216	arg1	wafers					1227:1232	the selected curcumin wafers	1205:1232	the selected curcumin wafers	1205:1232	Microbiological assay revealed the superiority of the selected curcumin wafers versus free curcumin in bacterial growth inhibition against Staphylococcus epidermidis and Staphylococcus aureus (MRSA) bacteria.
34044118	0	55	theme	curcumin	45:52	arg1	characterization					11:26	characterization	11:26	characterization	11:26	Design and characterization of highly porous curcumin loaded freeze-dried wafers for wound healing.
34044118	0	55	theme	curcumin	45:52	arg1	Design					0:5	Design	0:5	Design	0:5	Design and characterization of highly porous curcumin loaded freeze-dried wafers for wound healing.
34044118	12	56	theme	obtained	1601:1608	arg1	findings					1610:1617	the obtained findings	1597:1617	the obtained findings	1597:1617	To conclude, the obtained findings revealed that curcumin wafers offered a promising solution in the field of wound healing.
34044118	9	57	theme	curcumin	1218:1225	arg1	wafers					1227:1232	the selected curcumin wafers	1205:1232	the selected curcumin wafers	1205:1232	Microbiological assay revealed the superiority of the selected curcumin wafers versus free curcumin in bacterial growth inhibition against Staphylococcus epidermidis and Staphylococcus aureus (MRSA) bacteria.
34044118	7	58	theme	differential	811:822	arg1	calorimetry					833:843	differential scanning calorimetry	811:843	differential scanning calorimetry	811:843	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	7	59	theme	compressive	693:703	arg1	behavior					716:723	compressive mechanical behavior	693:723	compressive mechanical behavior	693:723	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	7	59	theme	compressive	693:703	arg1	testing					684:690	Porosity testing	675:690	Porosity testing	675:690	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	9	60	theme	growth	1268:1273	arg1	inhibition					1275:1284	bacterial growth inhibition	1258:1284	bacterial growth inhibition against Staphylococcus epidermidis and Staphylococcus aureus (MRSA) bacteria	1258:1361	Microbiological assay revealed the superiority of the selected curcumin wafers versus free curcumin in bacterial growth inhibition against Staphylococcus epidermidis and Staphylococcus aureus (MRSA) bacteria.
34044118	1	61	theme	research	117:124	arg1	goal					104:107	The goal	100:107	The goal of this research	100:124	The goal of this research was to evaluate the beneficial effects of topical curcumin loaded freeze-dried wafers in wound healing.
34044118	5	62	theme	resulted	468:475	arg1	wafers					477:482	The resulted wafers	464:482	The resulted wafers	464:482	The resulted wafers were examined by naked eye and their dimensions were measured using a caliper.
34044118	1	63	theme	wound	215:219	arg1	healing					221:227	wound healing	215:227	wound healing	215:227	The goal of this research was to evaluate the beneficial effects of topical curcumin loaded freeze-dried wafers in wound healing.
34044118	9	64	theme	wafers	1227:1232	arg1	superiority					1190:1200	the superiority	1186:1200	the superiority of the selected curcumin wafers	1186:1232	Microbiological assay revealed the superiority of the selected curcumin wafers versus free curcumin in bacterial growth inhibition against Staphylococcus epidermidis and Staphylococcus aureus (MRSA) bacteria.
34044118	7	65	theme	Porosity	675:682	arg1	behavior					716:723	compressive mechanical behavior	693:723	compressive mechanical behavior	693:723	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	7	65	theme	Porosity	675:682	arg1	examination					740:750	morphological examination	726:750	morphological examination using scanning electron microscopy	726:785	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	7	65	theme	Porosity	675:682	arg1	testing					684:690	Porosity testing	675:690	Porosity testing	675:690	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	7	65	theme	Porosity	675:682	arg1	behavior					796:803	thermal behavior	788:803	thermal behavior	788:803	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	6	66	theme	fabricated	656:665	arg1	wafers					667:672	the fabricated wafers	652:672	the fabricated wafers	652:672	% Drug content, in-vitro release and % water uptake tests were conducted to characterize the fabricated wafers.
34044118	2	67	with	cross-linking	265:277	arg1	beta					296:299	beta glycerophosphate	296:316	beta glycerophosphate under magnetic stirring	296:340	Curcumin wafers were fabricated by cross-linking of chitosan with beta glycerophosphate under magnetic stirring.
34044118	3	68	theme	Composite	343:351	arg1	wafers					353:358	Composite wafers	343:358	Composite wafers	343:358	Composite wafers were prepared by the addition of sodium hyaluronate.
34044118	9	69	theme	free	1241:1244	arg1	curcumin					1246:1253	free curcumin	1241:1253	free curcumin in bacterial growth inhibition against Staphylococcus epidermidis and Staphylococcus aureus (MRSA) bacteria	1241:1361	Microbiological assay revealed the superiority of the selected curcumin wafers versus free curcumin in bacterial growth inhibition against Staphylococcus epidermidis and Staphylococcus aureus (MRSA) bacteria.
34044118	7	70	theme	microbiological	965:979	arg1	assays					981:986	their microbiological assays	959:986	their microbiological assays	959:986	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	12	71	theme	healing	1700:1706	arg1	field					1685:1689	the field	1681:1689	the field of wound healing	1681:1706	To conclude, the obtained findings revealed that curcumin wafers offered a promising solution in the field of wound healing.
34044118	0	72	theme	freeze-dried	61:72	arg1	wafers					74:79	freeze-dried wafers	61:79	freeze-dried wafers for wound healing	61:97	Design and characterization of highly porous curcumin loaded freeze-dried wafers for wound healing.
34044118	1	73	from	effects	157:163	arg1	healing					221:227	wound healing	215:227	wound healing	215:227	The goal of this research was to evaluate the beneficial effects of topical curcumin loaded freeze-dried wafers in wound healing.
34044118	7	74	theme	thermal	788:794	arg1	testing					684:690	Porosity testing	675:690	Porosity testing	675:690	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	7	74	theme	thermal	788:794	arg1	behavior					796:803	thermal behavior	788:803	thermal behavior	788:803	Porosity testing, compressive mechanical behavior, morphological examination using scanning electron microscopy, thermal behavior using differential scanning calorimetry and Fourier transform infrared spectroscopy were all carried out on the optimized cross-linked wafers followed by their microbiological assays and cytotoxicity studies.
34044118	10	75	theme	anti-inflammatory	1368:1384	arg1	effects					1386:1392	The anti-inflammatory effects	1364:1392	The anti-inflammatory effects of the selected curcumin wafers	1364:1424	The anti-inflammatory effects of the selected curcumin wafers were evaluated against pro-inflammatory cytokines.
34044118	12	76	theme	wound	1694:1698	arg1	healing					1700:1706	wound healing	1694:1706	wound healing	1694:1706	To conclude, the obtained findings revealed that curcumin wafers offered a promising solution in the field of wound healing.
33360572	0	0	theme	transition	97:106	arg1	cows					117:120	transition Holstein cows	97:120	transition Holstein cows	97:120	Supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition Holstein cows.
33360572	2	1	theme	transition	497:506	arg1	cows					508:511	transition cows	497:511	transition cows	497:511	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	7	2	theme	increased	1092:1100	arg1	levels					1117:1122	increased immunoglobulin levels	1092:1122	increased immunoglobulin levels in colostrum	1092:1135	Beta-1,3-glucan treatment also improved the milk quality, as shown by reduced milk somatic cell count and increased immunoglobulin levels in colostrum.
33360572	3	3	theme	Fifty-four	514:523	arg1	cows					546:549	Fifty-four multiparous Holstein cows	514:549	Fifty-four multiparous Holstein cows	514:549	Fifty-four multiparous Holstein cows received a control diet or a diet supplemented with 5 or 10 g of beta-1,3-glucan per cow per day from 21 days before expected calving to 21 days after parturition.
33360572	1	4	theme	metabolic	265:273	arg1	stress					275:280	metabolic stress	265:280	metabolic stress	265:280	Dairy cows undergo dramatic physiological changes during the transition from late pregnancy to early lactation, which make them vulnerable to metabolic stress and immune dysfunction.
33360572	7	5	theme	immunoglobulin	1102:1115	arg1	levels					1117:1122	increased immunoglobulin levels	1092:1122	increased immunoglobulin levels in colostrum	1092:1135	Beta-1,3-glucan treatment also improved the milk quality, as shown by reduced milk somatic cell count and increased immunoglobulin levels in colostrum.
33360572	8	6	from	enhancement	1315:1325	arg1	cows					1341:1344	transition cows	1330:1344	transition cows	1330:1344	Notably, beta-1,3-glucan markedly reduced serum levels of pro-inflammatory cytokines and C-reactive protein, while elevated serum immunoglobulin levels, indicating its immunity enhancement in transition cows.
33360572	3	7	theme	multiparous	525:535	arg1	cows					546:549	Fifty-four multiparous Holstein cows	514:549	Fifty-four multiparous Holstein cows	514:549	Fifty-four multiparous Holstein cows received a control diet or a diet supplemented with 5 or 10 g of beta-1,3-glucan per cow per day from 21 days before expected calving to 21 days after parturition.
33360572	6	8	theme	milk	969:972	arg1	production					974:983	milk production	969:983	milk production	969:983	Data showed that supplementation with beta-1,3-glucan had no effect on milk composition, but increased milk production.
33360572	2	9	from	productivity	446:457	arg1	cows					508:511	transition cows	497:511	transition cows	497:511	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	3	10	theme	Holstein	537:544	arg1	cows					546:549	Fifty-four multiparous Holstein cows	514:549	Fifty-four multiparous Holstein cows	514:549	Fifty-four multiparous Holstein cows received a control diet or a diet supplemented with 5 or 10 g of beta-1,3-glucan per cow per day from 21 days before expected calving to 21 days after parturition.
33360572	3	11	theme	control	562:568	arg1	diet					570:573	a control diet	560:573	a control diet	560:573	Fifty-four multiparous Holstein cows received a control diet or a diet supplemented with 5 or 10 g of beta-1,3-glucan per cow per day from 21 days before expected calving to 21 days after parturition.
33360572	9	12	theme	serum	1453:1457	arg1	dismutase					1470:1478	serum superoxide dismutase	1453:1478	serum superoxide dismutase	1453:1478	Moreover, beta-1,3-glucan addition reduced the serum malondialdehyde level and enhanced the activities of serum superoxide dismutase and catalase, which enhanced the antioxidative capacity in transition cows.
33360572	0	13	theme	Holstein	108:115	arg1	cows					117:120	transition Holstein cows	97:120	transition Holstein cows	97:120	Supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition Holstein cows.
33360572	9	14	theme	beta-1,3-glucan	1357:1371	arg1	addition					1373:1380	beta-1,3-glucan addition	1357:1380	beta-1,3-glucan addition	1357:1380	Moreover, beta-1,3-glucan addition reduced the serum malondialdehyde level and enhanced the activities of serum superoxide dismutase and catalase, which enhanced the antioxidative capacity in transition cows.
33360572	2	15	from	effects	354:360	arg1	productivity					446:457	productivity	446:457	productivity	446:457	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	2	15	from	effects	354:360	arg1	immunity					460:467	immunity	460:467	immunity	460:467	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	2	15	from	effects	354:360	arg1	status					487:492	antioxidative status	473:492	antioxidative status	473:492	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	1	16	theme	immune	286:291	arg1	dysfunction					293:303	immune dysfunction	286:303	immune dysfunction	286:303	Dairy cows undergo dramatic physiological changes during the transition from late pregnancy to early lactation, which make them vulnerable to metabolic stress and immune dysfunction.
33360572	10	17	theme	transition	1665:1674	arg1	cows					1682:1685	transition dairy cows	1665:1685	transition dairy cows	1665:1685	In summary, supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition dairy cows.
33360572	0	18	from	immunity	60:67	arg1	cows					117:120	transition Holstein cows	97:120	transition Holstein cows	97:120	Supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition Holstein cows.
33360572	7	19	theme	somatic	1069:1075	arg1	count					1082:1086	reduced milk somatic cell count	1056:1086	reduced milk somatic cell count	1056:1086	Beta-1,3-glucan treatment also improved the milk quality, as shown by reduced milk somatic cell count and increased immunoglobulin levels in colostrum.
33360572	6	20	with	supplementation	883:897	arg1	beta-1,3-glucan					904:918	beta-1,3-glucan	904:918	beta-1,3-glucan	904:918	Data showed that supplementation with beta-1,3-glucan had no effect on milk composition, but increased milk production.
33360572	9	21	theme	superoxide	1459:1468	arg1	dismutase					1470:1478	serum superoxide dismutase	1453:1478	serum superoxide dismutase	1453:1478	Moreover, beta-1,3-glucan addition reduced the serum malondialdehyde level and enhanced the activities of serum superoxide dismutase and catalase, which enhanced the antioxidative capacity in transition cows.
33360572	9	22	theme	catalase	1484:1491	arg1	activities					1439:1448	the activities	1435:1448	the activities of serum superoxide dismutase and catalase, which enhanced the antioxidative capacity in transition cows	1435:1553	Moreover, beta-1,3-glucan addition reduced the serum malondialdehyde level and enhanced the activities of serum superoxide dismutase and catalase, which enhanced the antioxidative capacity in transition cows.
33360572	9	23	theme	dismutase	1470:1478	arg1	activities					1439:1448	the activities	1435:1448	the activities of serum superoxide dismutase and catalase, which enhanced the antioxidative capacity in transition cows	1435:1553	Moreover, beta-1,3-glucan addition reduced the serum malondialdehyde level and enhanced the activities of serum superoxide dismutase and catalase, which enhanced the antioxidative capacity in transition cows.
33360572	3	24	from	21 days	653:659	arg1	cow					636:638	cow	636:638	cow per day from 21 days before expected calving to 21 days after parturition	636:712	Fifty-four multiparous Holstein cows received a control diet or a diet supplemented with 5 or 10 g of beta-1,3-glucan per cow per day from 21 days before expected calving to 21 days after parturition.
33360572	2	25	from	status	487:492	arg1	cows					508:511	transition cows	497:511	transition cows	497:511	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	7	26	theme	cell	1077:1080	arg1	count					1082:1086	reduced milk somatic cell count	1056:1086	reduced milk somatic cell count	1056:1086	Beta-1,3-glucan treatment also improved the milk quality, as shown by reduced milk somatic cell count and increased immunoglobulin levels in colostrum.
33360572	1	27	theme	late	200:203	arg1	pregnancy					205:213	late pregnancy	200:213	late pregnancy	200:213	Dairy cows undergo dramatic physiological changes during the transition from late pregnancy to early lactation, which make them vulnerable to metabolic stress and immune dysfunction.
33360572	8	28	theme	serum	1180:1184	arg1	levels					1186:1191	serum levels	1180:1191	serum levels of pro-inflammatory cytokines and C-reactive protein	1180:1244	Notably, beta-1,3-glucan markedly reduced serum levels of pro-inflammatory cytokines and C-reactive protein, while elevated serum immunoglobulin levels, indicating its immunity enhancement in transition cows.
33360572	0	29	from	productivity	46:57	arg1	cows					117:120	transition Holstein cows	97:120	transition Holstein cows	97:120	Supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition Holstein cows.
33360572	7	30	theme	reduced	1056:1062	arg1	count					1082:1086	reduced milk somatic cell count	1056:1086	reduced milk somatic cell count	1056:1086	Beta-1,3-glucan treatment also improved the milk quality, as shown by reduced milk somatic cell count and increased immunoglobulin levels in colostrum.
33360572	2	31	from	immunity	460:467	arg1	cows					508:511	transition cows	497:511	transition cows	497:511	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	8	32	theme	elevated	1253:1260	arg1	levels					1283:1288	elevated serum immunoglobulin levels	1253:1288	elevated serum immunoglobulin levels	1253:1288	Notably, beta-1,3-glucan markedly reduced serum levels of pro-inflammatory cytokines and C-reactive protein, while elevated serum immunoglobulin levels, indicating its immunity enhancement in transition cows.
33360572	4	33	theme	relative	766:773	arg1	day					747:749	day -21, 1, and 21	747:764	day -21, 1, and 21 relative to calving	747:784	Blood samples were collected at day -21, 1, and 21 relative to calving.
33360572	7	34	theme	milk	1064:1067	arg1	count					1082:1086	reduced milk somatic cell count	1056:1086	reduced milk somatic cell count	1056:1086	Beta-1,3-glucan treatment also improved the milk quality, as shown by reduced milk somatic cell count and increased immunoglobulin levels in colostrum.
33360572	9	35	from	capacity	1527:1534	arg1	cows					1550:1553	transition cows	1539:1553	transition cows	1539:1553	Moreover, beta-1,3-glucan addition reduced the serum malondialdehyde level and enhanced the activities of serum superoxide dismutase and catalase, which enhanced the antioxidative capacity in transition cows.
33360572	2	36	theme	study	328:332	arg1	objective					310:318	The objective	306:318	The objective of this study	306:332	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	8	37	theme	serum	1262:1266	arg1	levels					1283:1288	elevated serum immunoglobulin levels	1253:1288	elevated serum immunoglobulin levels	1253:1288	Notably, beta-1,3-glucan markedly reduced serum levels of pro-inflammatory cytokines and C-reactive protein, while elevated serum immunoglobulin levels, indicating its immunity enhancement in transition cows.
33360572	2	38	theme	product	394:400	arg1	effects					354:360	the effects	350:360	the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows	350:511	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	9	39	theme	antioxidative	1513:1525	arg1	capacity					1527:1534	the antioxidative capacity	1509:1534	the antioxidative capacity in transition cows	1509:1553	Moreover, beta-1,3-glucan addition reduced the serum malondialdehyde level and enhanced the activities of serum superoxide dismutase and catalase, which enhanced the antioxidative capacity in transition cows.
33360572	10	40	from	immunity	1628:1635	arg1	cows					1682:1685	transition dairy cows	1665:1685	transition dairy cows	1665:1685	In summary, supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition dairy cows.
33360572	1	41	theme	early	218:222	arg1	lactation					224:232	early lactation	218:232	early lactation	218:232	Dairy cows undergo dramatic physiological changes during the transition from late pregnancy to early lactation, which make them vulnerable to metabolic stress and immune dysfunction.
33360572	10	42	theme	antioxidative	1641:1653	arg1	status					1655:1660	antioxidative status	1641:1660	antioxidative status	1641:1660	In summary, supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition dairy cows.
33360572	6	43	theme	milk	937:940	arg1	composition					942:952	milk composition	937:952	milk composition	937:952	Data showed that supplementation with beta-1,3-glucan had no effect on milk composition, but increased milk production.
33360572	1	44	theme	Dairy	123:127	arg1	cows					129:132	Dairy cows	123:132	Dairy cows	123:132	Dairy cows undergo dramatic physiological changes during the transition from late pregnancy to early lactation, which make them vulnerable to metabolic stress and immune dysfunction.
33360572	2	45	theme	%	424:424	arg1	beta-1,3-glucan					426:440	50% beta-1,3-glucan	422:440	50% beta-1,3-glucan	422:440	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	8	46	theme	cytokines	1213:1221	arg1	levels					1186:1191	serum levels	1180:1191	serum levels of pro-inflammatory cytokines and C-reactive protein	1180:1244	Notably, beta-1,3-glucan markedly reduced serum levels of pro-inflammatory cytokines and C-reactive protein, while elevated serum immunoglobulin levels, indicating its immunity enhancement in transition cows.
33360572	8	47	theme	transition	1330:1339	arg1	cows					1341:1344	transition cows	1330:1344	transition cows	1330:1344	Notably, beta-1,3-glucan markedly reduced serum levels of pro-inflammatory cytokines and C-reactive protein, while elevated serum immunoglobulin levels, indicating its immunity enhancement in transition cows.
33360572	2	48	theme	50	422:423	arg1	%					424:424	%	424:424	%	424:424	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	2	49	theme	antioxidative	473:485	arg1	status					487:492	antioxidative status	473:492	antioxidative status	473:492	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	7	50	from	count	1082:1086	arg1	colostrum					1127:1135	colostrum	1127:1135	colostrum	1127:1135	Beta-1,3-glucan treatment also improved the milk quality, as shown by reduced milk somatic cell count and increased immunoglobulin levels in colostrum.
33360572	8	51	theme	pro-inflammatory	1196:1211	arg1	cytokines					1213:1221	pro-inflammatory cytokines	1196:1221	pro-inflammatory cytokines	1196:1221	Notably, beta-1,3-glucan markedly reduced serum levels of pro-inflammatory cytokines and C-reactive protein, while elevated serum immunoglobulin levels, indicating its immunity enhancement in transition cows.
33360572	0	52	from	status	87:92	arg1	cows					117:120	transition Holstein cows	97:120	transition Holstein cows	97:120	Supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition Holstein cows.
33360572	8	53	theme	immunity	1306:1313	arg1	enhancement					1315:1325	its immunity enhancement	1302:1325	its immunity enhancement in transition cows	1302:1344	Notably, beta-1,3-glucan markedly reduced serum levels of pro-inflammatory cytokines and C-reactive protein, while elevated serum immunoglobulin levels, indicating its immunity enhancement in transition cows.
33360572	8	54	theme	C-reactive	1227:1236	arg1	protein					1238:1244	C-reactive protein	1227:1244	C-reactive protein	1227:1244	Notably, beta-1,3-glucan markedly reduced serum levels of pro-inflammatory cytokines and C-reactive protein, while elevated serum immunoglobulin levels, indicating its immunity enhancement in transition cows.
33360572	7	55	theme	milk	1030:1033	arg1	quality					1035:1041	the milk quality	1026:1041	the milk quality	1026:1041	Beta-1,3-glucan treatment also improved the milk quality, as shown by reduced milk somatic cell count and increased immunoglobulin levels in colostrum.
33360572	10	56	theme	dairy	1676:1680	arg1	cows					1682:1685	transition dairy cows	1665:1685	transition dairy cows	1665:1685	In summary, supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition dairy cows.
33360572	9	57	theme	serum	1394:1398	arg1	level					1416:1420	the serum malondialdehyde level	1390:1420	the serum malondialdehyde level	1390:1420	Moreover, beta-1,3-glucan addition reduced the serum malondialdehyde level and enhanced the activities of serum superoxide dismutase and catalase, which enhanced the antioxidative capacity in transition cows.
33360572	10	58	from	status	1655:1660	arg1	cows					1682:1685	transition dairy cows	1665:1685	transition dairy cows	1665:1685	In summary, supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition dairy cows.
33360572	2	59	contain	containing	411:420	arg1	Aleta™					403:408	Aleta™	403:408	Aleta™	403:408	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	2	59	contain	containing	411:420	arg2	beta-1,3-glucan					426:440	50% beta-1,3-glucan	422:440	50% beta-1,3-glucan	422:440	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	4	60	theme	Blood	715:719	arg1	samples					721:727	Blood samples	715:727	Blood samples	715:727	Blood samples were collected at day -21, 1, and 21 relative to calving.
33360572	9	61	theme	malondialdehyde	1400:1414	arg1	level					1416:1420	the serum malondialdehyde level	1390:1420	the serum malondialdehyde level	1390:1420	Moreover, beta-1,3-glucan addition reduced the serum malondialdehyde level and enhanced the activities of serum superoxide dismutase and catalase, which enhanced the antioxidative capacity in transition cows.
33360572	10	62	from	productivity	1614:1625	arg1	cows					1682:1685	transition dairy cows	1665:1685	transition dairy cows	1665:1685	In summary, supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition dairy cows.
33360572	0	63	with	Supplementation	0:14	arg1	beta-1,3-glucan					21:35	beta-1,3-glucan	21:35	beta-1,3-glucan	21:35	Supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition Holstein cows.
33360572	1	64	theme	dramatic	142:149	arg1	changes					165:171	dramatic physiological changes	142:171	dramatic physiological changes	142:171	Dairy cows undergo dramatic physiological changes during the transition from late pregnancy to early lactation, which make them vulnerable to metabolic stress and immune dysfunction.
33360572	7	65	theme	Beta-1,3-glucan	986:1000	arg1	treatment					1002:1010	Beta-1,3-glucan treatment	986:1010	Beta-1,3-glucan treatment	986:1010	Beta-1,3-glucan treatment also improved the milk quality, as shown by reduced milk somatic cell count and increased immunoglobulin levels in colostrum.
33360572	2	66	dep	product	394:400	arg1	Aleta™					403:408	Aleta™	403:408	Aleta™	403:408	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	1	67	from	pregnancy	205:213	arg1	transition					184:193	the transition	180:193	the transition from late pregnancy to early lactation, which make them vulnerable to metabolic stress and immune dysfunction	180:303	Dairy cows undergo dramatic physiological changes during the transition from late pregnancy to early lactation, which make them vulnerable to metabolic stress and immune dysfunction.
33360572	1	68	theme	physiological	151:163	arg1	changes					165:171	dramatic physiological changes	142:171	dramatic physiological changes	142:171	Dairy cows undergo dramatic physiological changes during the transition from late pregnancy to early lactation, which make them vulnerable to metabolic stress and immune dysfunction.
33360572	9	69	theme	transition	1539:1548	arg1	cows					1550:1553	transition cows	1539:1553	transition cows	1539:1553	Moreover, beta-1,3-glucan addition reduced the serum malondialdehyde level and enhanced the activities of serum superoxide dismutase and catalase, which enhanced the antioxidative capacity in transition cows.
33360572	6	70	contain	had	920:922	arg2	effect					927:932	no effect	924:932	no effect	924:932	Data showed that supplementation with beta-1,3-glucan had no effect on milk composition, but increased milk production.
33360572	6	70	contain	had	920:922	arg1	supplementation					883:897	supplementation	883:897	supplementation with beta-1,3-glucan	883:918	Data showed that supplementation with beta-1,3-glucan had no effect on milk composition, but increased milk production.
33360572	3	71	theme	expected	668:675	arg1	calving					677:683	expected calving	668:683	expected calving to 21 days after parturition	668:712	Fifty-four multiparous Holstein cows received a control diet or a diet supplemented with 5 or 10 g of beta-1,3-glucan per cow per day from 21 days before expected calving to 21 days after parturition.
33360572	10	72	with	supplementation	1568:1582	arg1	beta-1,3-glucan					1589:1603	beta-1,3-glucan	1589:1603	beta-1,3-glucan	1589:1603	In summary, supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition dairy cows.
33360572	8	73	theme	immunoglobulin	1268:1281	arg1	levels					1283:1288	elevated serum immunoglobulin levels	1253:1288	elevated serum immunoglobulin levels	1253:1288	Notably, beta-1,3-glucan markedly reduced serum levels of pro-inflammatory cytokines and C-reactive protein, while elevated serum immunoglobulin levels, indicating its immunity enhancement in transition cows.
33360572	2	74	theme	beta-1,3-glucan	378:392	arg1	product					394:400	a commercial beta-1,3-glucan product	365:400	a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan)	365:441	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33360572	8	75	theme	protein	1238:1244	arg1	levels					1186:1191	serum levels	1180:1191	serum levels of pro-inflammatory cytokines and C-reactive protein	1180:1244	Notably, beta-1,3-glucan markedly reduced serum levels of pro-inflammatory cytokines and C-reactive protein, while elevated serum immunoglobulin levels, indicating its immunity enhancement in transition cows.
33360572	0	76	theme	antioxidative	73:85	arg1	status					87:92	antioxidative status	73:92	antioxidative status	73:92	Supplementation with beta-1,3-glucan improves productivity, immunity and antioxidative status in transition Holstein cows.
33360572	7	77	from	levels	1117:1122	arg1	colostrum					1127:1135	colostrum	1127:1135	colostrum	1127:1135	Beta-1,3-glucan treatment also improved the milk quality, as shown by reduced milk somatic cell count and increased immunoglobulin levels in colostrum.
33360572	3	78	theme	beta-1,3-glucan	616:630	arg1	beta-1,3-glucan					616:630	beta-1,3-glucan	616:630	beta-1,3-glucan	616:630	Fifty-four multiparous Holstein cows received a control diet or a diet supplemented with 5 or 10 g of beta-1,3-glucan per cow per day from 21 days before expected calving to 21 days after parturition.
33360572	3	78	theme	beta-1,3-glucan	616:630	arg1	5					603:603	5	603:603	5	603:603	Fifty-four multiparous Holstein cows received a control diet or a diet supplemented with 5 or 10 g of beta-1,3-glucan per cow per day from 21 days before expected calving to 21 days after parturition.
33360572	2	79	theme	commercial	367:376	arg1	product					394:400	a commercial beta-1,3-glucan product	365:400	a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan)	365:441	The objective of this study was to evaluate the effects of a commercial beta-1,3-glucan product (Aleta™, containing 50% beta-1,3-glucan) on productivity, immunity and antioxidative status in transition cows.
33559665	4	0	theme	mass	910:913	arg1	spectrometry					915:926	time-of-flight secondary ion mass spectrometry	881:926	time-of-flight secondary ion mass spectrometry	881:926	The chemical compositions of each surface were determined via time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy.
33559665	6	1	theme	adhered	1367:1373	arg1	cells					1361:1365	the cells	1357:1365	the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces	1357:1431	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	3	2	dep	hydroxy	604:610	arg1	hydrophilic					617:627	hydrophilic	617:627	hydrophilic	617:627	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	3	2	dep	hydroxy	604:610	arg1	OH					613:614	OH	613:614	OH	613:614	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	3	2	dep	hydroxy	604:610	arg1	nonionic					633:640	nonionic	633:640	nonionic	633:640	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	3	3	theme	different	788:796	arg1	chemistries					806:816	different surface chemistries	788:816	different surface chemistries	788:816	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	7	4	theme	SO3H-modified	1581:1593	arg1	surfaces					1608:1615	the SO3H-modified polyrotaxane surfaces	1577:1615	the SO3H-modified polyrotaxane surfaces	1577:1615	Interestingly, the SO3H-modified polyrotaxane surfaces promoted both osteoblast and adipocyte differentiation.
33559665	0	5	theme	surfaces	72:79	arg1	surfaces					72:79	polyrotaxane surfaces	59:79	polyrotaxane surfaces	59:79	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	0	5	theme	surfaces	72:79	arg1	mobility					25:32	molecular mobility	15:32	molecular mobility	15:32	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	0	5	theme	surfaces	72:79	arg1	groups					49:54	functional groups	38:54	functional groups of polyrotaxane surfaces	38:79	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	1	6	dep	glycol	266:271	arg1	e.g.					246:249	e.g.	246:249	e.g.	246:249	Polyrotaxanes are supramolecular assemblies consisting of cyclic molecules (e.g., α-cyclodextrins) and linear polymer chains (e.g., poly[ethylene glycol]), in which cyclic molecules can move along the polymer chain.
33559665	3	7	dep	methyl	563:568	arg1	hydrophobic					576:586	hydrophobic	576:586	hydrophobic	576:586	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	3	7	dep	methyl	563:568	arg1	nonionic					593:600	nonionic	593:600	nonionic	593:600	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	3	7	dep	methyl	563:568	arg1	CH3					571:573	CH3	571:573	CH3	571:573	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	3	8	theme	polyrotaxane	761:772	arg1	surfaces					774:781	polyrotaxane surfaces	761:781	polyrotaxane surfaces	761:781	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	7	9	theme	polyrotaxane	1595:1606	arg1	surfaces					1608:1615	the SO3H-modified polyrotaxane surfaces	1577:1615	the SO3H-modified polyrotaxane surfaces	1577:1615	Interestingly, the SO3H-modified polyrotaxane surfaces promoted both osteoblast and adipocyte differentiation.
33559665	4	10	theme	chemical	823:830	arg1	compositions					832:843	The chemical compositions	819:843	The chemical compositions of each surface	819:859	The chemical compositions of each surface were determined via time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy.
33559665	8	11	from	mobility	1688:1695	arg1	surfaces					1751:1758	the SO3H-modified polyrotaxane surfaces	1720:1758	the SO3H-modified polyrotaxane surfaces	1720:1758	High molecular mobility and negative charge on the SO3H-modified polyrotaxane surfaces are expected to contribute to the facilitation of both osteoblast and adipocyte differentiation.
33559665	3	12	theme	Polyrotaxane-based	510:527	arg1	copolymers					538:547	Polyrotaxane-based triblock copolymers	510:547	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups	510:698	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	4	13	theme	surface	853:859	arg1	compositions					832:843	The chemical compositions	819:843	The chemical compositions of each surface	819:859	The chemical compositions of each surface were determined via time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy.
33559665	1	14	theme	polymer	321:327	arg1	chain					329:333	the polymer chain	317:333	the polymer chain	317:333	Polyrotaxanes are supramolecular assemblies consisting of cyclic molecules (e.g., α-cyclodextrins) and linear polymer chains (e.g., poly[ethylene glycol]), in which cyclic molecules can move along the polymer chain.
33559665	8	15	theme	osteoblast	1815:1824	arg1	facilitation					1794:1805	the facilitation	1790:1805	the facilitation of both osteoblast and adipocyte differentiation	1790:1854	High molecular mobility and negative charge on the SO3H-modified polyrotaxane surfaces are expected to contribute to the facilitation of both osteoblast and adipocyte differentiation.
33559665	3	16	theme	triblock	529:536	arg1	copolymers					538:547	Polyrotaxane-based triblock copolymers	510:547	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups	510:698	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	1	17	theme	poly[ethylene	252:264	arg1	glycol					266:271	poly[ethylene glycol	252:271	poly[ethylene glycol	252:271	Polyrotaxanes are supramolecular assemblies consisting of cyclic molecules (e.g., α-cyclodextrins) and linear polymer chains (e.g., poly[ethylene glycol]), in which cyclic molecules can move along the polymer chain.
33559665	0	18	theme	mesenchymal	96:106	arg1	cells					113:117	mesenchymal stem cells	96:117	mesenchymal stem cells	96:117	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	6	19	theme	polyrotaxane	1228:1239	arg1	surface					1241:1247	each polyrotaxane surface	1223:1247	each polyrotaxane surface	1223:1247	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	6	20	theme	adipocyte	1458:1466	arg1	differentiation					1468:1482	adipocyte differentiation	1458:1482	adipocyte differentiation	1458:1482	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	8	21	from	charge	1710:1715	arg1	surfaces					1751:1758	the SO3H-modified polyrotaxane surfaces	1720:1758	the SO3H-modified polyrotaxane surfaces	1720:1758	High molecular mobility and negative charge on the SO3H-modified polyrotaxane surfaces are expected to contribute to the facilitation of both osteoblast and adipocyte differentiation.
33559665	5	22	theme	zeta	1033:1036	arg1	potential					1038:1046	zeta potential	1033:1046	zeta potential	1033:1046	The contact angle hysteresis reflecting the molecular mobility and zeta potential of each polyrotaxane surface changed depending on the functional groups.
33559665	4	23	theme	X-ray	932:936	arg1	spectroscopy					952:963	X-ray photoelectron spectroscopy	932:963	X-ray photoelectron spectroscopy	932:963	The chemical compositions of each surface were determined via time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy.
33559665	3	24	theme	NH2	651:653	arg1	cationic					656:663	amino (NH2, cationic)	644:664	cationic	656:663	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	5	25	theme	surface	1069:1075	arg1	mobility					1020:1027	molecular mobility	1010:1027	molecular mobility	1010:1027	The contact angle hysteresis reflecting the molecular mobility and zeta potential of each polyrotaxane surface changed depending on the functional groups.
33559665	5	25	theme	surface	1069:1075	arg1	potential					1038:1046	zeta potential	1033:1046	zeta potential	1033:1046	The contact angle hysteresis reflecting the molecular mobility and zeta potential of each polyrotaxane surface changed depending on the functional groups.
33559665	0	26	theme	Dual	0:3	arg1	effect					5:10	Dual effect	0:10	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.	0:118	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	3	27	theme	surface	798:804	arg1	chemistries					806:816	different surface chemistries	788:816	different surface chemistries	788:816	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	1	28	theme	cyclic	178:183	arg1	molecules					185:193	cyclic molecules	178:193	cyclic molecules (e.g., α-cyclodextrins)	178:217	Polyrotaxanes are supramolecular assemblies consisting of cyclic molecules (e.g., α-cyclodextrins) and linear polymer chains (e.g., poly[ethylene glycol]), in which cyclic molecules can move along the polymer chain.
33559665	1	28	theme	cyclic	178:183	arg1	α-cyclodextrins					202:216	α-cyclodextrins	202:216	α-cyclodextrins	202:216	Polyrotaxanes are supramolecular assemblies consisting of cyclic molecules (e.g., α-cyclodextrins) and linear polymer chains (e.g., poly[ethylene glycol]), in which cyclic molecules can move along the polymer chain.
33559665	8	29	theme	SO3H-modified	1724:1736	arg1	surfaces					1751:1758	the SO3H-modified polyrotaxane surfaces	1720:1758	the SO3H-modified polyrotaxane surfaces	1720:1758	High molecular mobility and negative charge on the SO3H-modified polyrotaxane surfaces are expected to contribute to the facilitation of both osteoblast and adipocyte differentiation.
33559665	4	30	theme	ion	906:908	arg1	spectrometry					915:926	time-of-flight secondary ion mass spectrometry	881:926	time-of-flight secondary ion mass spectrometry	881:926	The chemical compositions of each surface were determined via time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy.
33559665	4	31	theme	secondary	896:904	arg1	spectrometry					915:926	time-of-flight secondary ion mass spectrometry	881:926	time-of-flight secondary ion mass spectrometry	881:926	The chemical compositions of each surface were determined via time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy.
33559665	6	32	theme	polyrotaxane	1539:1550	arg1	surfaces					1552:1559	the unmodified and CH3-modified polyrotaxane surfaces	1507:1559	the unmodified and CH3-modified polyrotaxane surfaces	1507:1559	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	0	33	from	effect	5:10	arg1	fate					88:91	the fate	84:91	the fate of mesenchymal stem cells	84:117	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	3	34	theme	sulfo	671:675	arg1	groups					693:698	sulfo (SO3H, anionic) groups	671:698	groups	693:698	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	4	35	theme	photoelectron	938:950	arg1	spectroscopy					952:963	X-ray photoelectron spectroscopy	932:963	X-ray photoelectron spectroscopy	932:963	The chemical compositions of each surface were determined via time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy.
33559665	6	36	theme	CH3-modified	1526:1537	arg1	surfaces					1552:1559	the unmodified and CH3-modified polyrotaxane surfaces	1507:1559	the unmodified and CH3-modified polyrotaxane surfaces	1507:1559	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	0	37	theme	molecular	15:23	arg1	mobility					25:32	molecular mobility	15:32	molecular mobility	15:32	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	0	38	theme	cells	113:117	arg1	fate					88:91	the fate	84:91	the fate of mesenchymal stem cells	84:117	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	6	39	theme	human	1182:1186	arg1	cells					1205:1209	human mesenchymal stem cells	1182:1209	human mesenchymal stem cells cultured on each polyrotaxane surface	1182:1247	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	2	40	theme	groups	379:384	arg1	effect					358:363	the effect	354:363	the effect of functional groups introduced into the α-cyclodextrins of polyrotaxane on cell responses such as adhesion, proliferation, and differentiation	354:507	Here, we examined the effect of functional groups introduced into the α-cyclodextrins of polyrotaxane on cell responses such as adhesion, proliferation, and differentiation.
33559665	0	41	theme	stem	108:111	arg1	cells					113:117	mesenchymal stem cells	96:117	mesenchymal stem cells	96:117	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	5	42	theme	molecular	1010:1018	arg1	mobility					1020:1027	molecular mobility	1010:1027	molecular mobility	1010:1027	The contact angle hysteresis reflecting the molecular mobility and zeta potential of each polyrotaxane surface changed depending on the functional groups.
33559665	6	43	theme	unmodified	1511:1520	arg1	surfaces					1552:1559	the unmodified and CH3-modified polyrotaxane surfaces	1507:1559	the unmodified and CH3-modified polyrotaxane surfaces	1507:1559	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	2	44	theme	functional	368:377	arg1	groups					379:384	functional groups	368:384	functional groups introduced into the α-cyclodextrins of polyrotaxane	368:436	Here, we examined the effect of functional groups introduced into the α-cyclodextrins of polyrotaxane on cell responses such as adhesion, proliferation, and differentiation.
33559665	2	45	theme	cell	441:444	arg1	proliferation					474:486	proliferation	474:486	proliferation	474:486	Here, we examined the effect of functional groups introduced into the α-cyclodextrins of polyrotaxane on cell responses such as adhesion, proliferation, and differentiation.
33559665	2	45	theme	cell	441:444	arg1	responses					446:454	cell responses	441:454	cell responses such as adhesion, proliferation, and differentiation	441:507	Here, we examined the effect of functional groups introduced into the α-cyclodextrins of polyrotaxane on cell responses such as adhesion, proliferation, and differentiation.
33559665	2	45	theme	cell	441:444	arg1	adhesion					464:471	adhesion	464:471	adhesion	464:471	Here, we examined the effect of functional groups introduced into the α-cyclodextrins of polyrotaxane on cell responses such as adhesion, proliferation, and differentiation.
33559665	2	45	theme	cell	441:444	arg1	differentiation					493:507	differentiation	493:507	differentiation	493:507	Here, we examined the effect of functional groups introduced into the α-cyclodextrins of polyrotaxane on cell responses such as adhesion, proliferation, and differentiation.
33559665	8	46	theme	molecular	1678:1686	arg1	mobility					1688:1695	High molecular mobility	1673:1695	High molecular mobility	1673:1695	High molecular mobility and negative charge on the SO3H-modified polyrotaxane surfaces are expected to contribute to the facilitation of both osteoblast and adipocyte differentiation.
33559665	0	47	theme	mobility	25:32	arg1	effect					5:10	Dual effect	0:10	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.	0:118	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	3	48	theme	anionic	684:690	arg1	groups					693:698	sulfo (SO3H, anionic) groups	671:698	groups	693:698	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	6	49	theme	polyrotaxane	1289:1300	arg1	surfaces					1302:1309	the SO3H-modified polyrotaxane surfaces	1271:1309	the SO3H-modified polyrotaxane surfaces	1271:1309	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	3	50	theme	SO3H	678:681	arg1	groups					693:698	sulfo (SO3H, anionic) groups	671:698	groups	693:698	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	6	51	theme	stem	1200:1203	arg1	cells					1205:1209	human mesenchymal stem cells	1182:1209	human mesenchymal stem cells cultured on each polyrotaxane surface	1182:1247	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	6	52	theme	osteoblast	1321:1330	arg1	differentiation					1332:1346	osteoblast differentiation	1321:1346	osteoblast differentiation	1321:1346	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	0	53	theme	groups	49:54	arg1	effect					5:10	Dual effect	0:10	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.	0:118	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	5	54	theme	functional	1102:1111	arg1	groups					1113:1118	the functional groups	1098:1118	the functional groups	1098:1118	The contact angle hysteresis reflecting the molecular mobility and zeta potential of each polyrotaxane surface changed depending on the functional groups.
33559665	6	55	theme	SO3H-modified	1275:1287	arg1	surfaces					1302:1309	the SO3H-modified polyrotaxane surfaces	1271:1309	the SO3H-modified polyrotaxane surfaces	1271:1309	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	4	56	theme	time-of-flight	881:894	arg1	spectrometry					915:926	time-of-flight secondary ion mass spectrometry	881:926	time-of-flight secondary ion mass spectrometry	881:926	The chemical compositions of each surface were determined via time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy.
33559665	6	57	theme	mesenchymal	1188:1198	arg1	cells					1205:1209	human mesenchymal stem cells	1182:1209	human mesenchymal stem cells cultured on each polyrotaxane surface	1182:1247	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	6	58	theme	polyrotaxane	1411:1422	arg1	surfaces					1424:1431	SO3H-modified polyrotaxane surfaces	1397:1431	SO3H-modified polyrotaxane surfaces	1397:1431	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	0	59	theme	functional	38:47	arg1	surfaces					72:79	polyrotaxane surfaces	59:79	polyrotaxane surfaces	59:79	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	0	59	theme	functional	38:47	arg1	groups					49:54	functional groups	38:54	functional groups of polyrotaxane surfaces	38:79	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	1	60	theme	cyclic	285:290	arg1	molecules					292:300	cyclic molecules	285:300	cyclic molecules	285:300	Polyrotaxanes are supramolecular assemblies consisting of cyclic molecules (e.g., α-cyclodextrins) and linear polymer chains (e.g., poly[ethylene glycol]), in which cyclic molecules can move along the polymer chain.
33559665	5	61	theme	polyrotaxane	1056:1067	arg1	surface					1069:1075	each polyrotaxane surface	1051:1075	each polyrotaxane surface	1051:1075	The contact angle hysteresis reflecting the molecular mobility and zeta potential of each polyrotaxane surface changed depending on the functional groups.
33559665	5	62	theme	angle	978:982	arg1	hysteresis					984:993	The contact angle hysteresis	966:993	The contact angle hysteresis reflecting the molecular mobility and zeta potential of each polyrotaxane surface	966:1075	The contact angle hysteresis reflecting the molecular mobility and zeta potential of each polyrotaxane surface changed depending on the functional groups.
33559665	5	63	theme	contact	970:976	arg1	hysteresis					984:993	The contact angle hysteresis	966:993	The contact angle hysteresis reflecting the molecular mobility and zeta potential of each polyrotaxane surface	966:1075	The contact angle hysteresis reflecting the molecular mobility and zeta potential of each polyrotaxane surface changed depending on the functional groups.
33559665	8	64	theme	differentiation	1840:1854	arg1	facilitation					1794:1805	the facilitation	1790:1805	the facilitation of both osteoblast and adipocyte differentiation	1790:1854	High molecular mobility and negative charge on the SO3H-modified polyrotaxane surfaces are expected to contribute to the facilitation of both osteoblast and adipocyte differentiation.
33559665	7	65	theme	adipocyte	1646:1654	arg1	differentiation					1656:1670	adipocyte differentiation	1646:1670	adipocyte differentiation	1646:1670	Interestingly, the SO3H-modified polyrotaxane surfaces promoted both osteoblast and adipocyte differentiation.
33559665	8	66	theme	High	1673:1676	arg1	mobility					1688:1695	High molecular mobility	1673:1695	High molecular mobility	1673:1695	High molecular mobility and negative charge on the SO3H-modified polyrotaxane surfaces are expected to contribute to the facilitation of both osteoblast and adipocyte differentiation.
33559665	1	67	dep	α-cyclodextrins	202:216	arg1	e.g.					196:199	e.g.	196:199	e.g.	196:199	Polyrotaxanes are supramolecular assemblies consisting of cyclic molecules (e.g., α-cyclodextrins) and linear polymer chains (e.g., poly[ethylene glycol]), in which cyclic molecules can move along the polymer chain.
33559665	8	68	theme	adipocyte	1830:1838	arg1	differentiation					1840:1854	adipocyte differentiation	1830:1854	adipocyte differentiation	1830:1854	High molecular mobility and negative charge on the SO3H-modified polyrotaxane surfaces are expected to contribute to the facilitation of both osteoblast and adipocyte differentiation.
33559665	8	69	theme	negative	1701:1708	arg1	charge					1710:1715	negative charge	1701:1715	negative charge on the SO3H-modified polyrotaxane surfaces	1701:1758	High molecular mobility and negative charge on the SO3H-modified polyrotaxane surfaces are expected to contribute to the facilitation of both osteoblast and adipocyte differentiation.
33559665	6	70	theme	adhered	1260:1266	arg1	cells					1254:1258	the cells	1250:1258	the cells adhered to the SO3H-modified polyrotaxane surfaces	1250:1309	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	6	71	theme	adipocyte	1141:1149	arg1	differentiation					1151:1165	adipocyte differentiation	1141:1165	adipocyte differentiation	1141:1165	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	3	72	theme	culture	734:740	arg1	plate					742:746	the culture plate	730:746	the culture plate	730:746	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	1	73	theme	linear	223:228	arg1	chains					238:243	linear polymer chains	223:243	linear polymer chains (e.g., poly[ethylene glycol])	223:273	Polyrotaxanes are supramolecular assemblies consisting of cyclic molecules (e.g., α-cyclodextrins) and linear polymer chains (e.g., poly[ethylene glycol]), in which cyclic molecules can move along the polymer chain.
33559665	0	74	theme	polyrotaxane	59:70	arg1	surfaces					72:79	polyrotaxane surfaces	59:79	polyrotaxane surfaces	59:79	Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells.
33559665	6	75	theme	SO3H-modified	1397:1409	arg1	surfaces					1424:1431	SO3H-modified polyrotaxane surfaces	1397:1431	SO3H-modified polyrotaxane surfaces	1397:1431	When osteoblast and adipocyte differentiation was induced in human mesenchymal stem cells cultured on each polyrotaxane surface, the cells adhered to the SO3H-modified polyrotaxane surfaces exhibited osteoblast differentiation, whereas the cells adhered to the OH-, NH2-, and SO3H-modified polyrotaxane surfaces preferentially underwent adipocyte differentiation compared with those on the unmodified and CH3-modified polyrotaxane surfaces.
33559665	2	76	from	effect	358:363	arg1	proliferation					474:486	proliferation	474:486	proliferation	474:486	Here, we examined the effect of functional groups introduced into the α-cyclodextrins of polyrotaxane on cell responses such as adhesion, proliferation, and differentiation.
33559665	2	76	from	effect	358:363	arg1	responses					446:454	cell responses	441:454	cell responses such as adhesion, proliferation, and differentiation	441:507	Here, we examined the effect of functional groups introduced into the α-cyclodextrins of polyrotaxane on cell responses such as adhesion, proliferation, and differentiation.
33559665	2	76	from	effect	358:363	arg1	adhesion					464:471	adhesion	464:471	adhesion	464:471	Here, we examined the effect of functional groups introduced into the α-cyclodextrins of polyrotaxane on cell responses such as adhesion, proliferation, and differentiation.
33559665	2	76	from	effect	358:363	arg1	differentiation					493:507	differentiation	493:507	differentiation	493:507	Here, we examined the effect of functional groups introduced into the α-cyclodextrins of polyrotaxane on cell responses such as adhesion, proliferation, and differentiation.
33559665	3	77	theme	plate	742:746	arg1	surface					719:725	the surface	715:725	the surface of the culture plate	715:746	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	1	78	theme	polymer	230:236	arg1	chains					238:243	linear polymer chains	223:243	linear polymer chains (e.g., poly[ethylene glycol])	223:273	Polyrotaxanes are supramolecular assemblies consisting of cyclic molecules (e.g., α-cyclodextrins) and linear polymer chains (e.g., poly[ethylene glycol]), in which cyclic molecules can move along the polymer chain.
33559665	2	79	theme	polyrotaxane	425:436	arg1	α-cyclodextrins					406:420	the α-cyclodextrins	402:420	the α-cyclodextrins of polyrotaxane	402:436	Here, we examined the effect of functional groups introduced into the α-cyclodextrins of polyrotaxane on cell responses such as adhesion, proliferation, and differentiation.
33559665	3	80	theme	amino	644:648	arg1	cationic					656:663	amino (NH2, cationic)	644:664	cationic	656:663	Polyrotaxane-based triblock copolymers modified with methyl (CH3, hydrophobic, and nonionic), hydroxy (OH, hydrophilic and nonionic), amino (NH2, cationic), and sulfo (SO3H, anionic) groups were coated on the surface of the culture plate to fabricate polyrotaxane surfaces with different surface chemistries.
33559665	1	81	theme	supramolecular	138:151	arg1	Polyrotaxanes					120:132	Polyrotaxanes	120:132	Polyrotaxanes	120:132	Polyrotaxanes are supramolecular assemblies consisting of cyclic molecules (e.g., α-cyclodextrins) and linear polymer chains (e.g., poly[ethylene glycol]), in which cyclic molecules can move along the polymer chain.
33559665	1	81	theme	supramolecular	138:151	arg1	assemblies					153:162	supramolecular assemblies	138:162	supramolecular assemblies	138:162	Polyrotaxanes are supramolecular assemblies consisting of cyclic molecules (e.g., α-cyclodextrins) and linear polymer chains (e.g., poly[ethylene glycol]), in which cyclic molecules can move along the polymer chain.
33559665	8	82	theme	polyrotaxane	1738:1749	arg1	surfaces					1751:1758	the SO3H-modified polyrotaxane surfaces	1720:1758	the SO3H-modified polyrotaxane surfaces	1720:1758	High molecular mobility and negative charge on the SO3H-modified polyrotaxane surfaces are expected to contribute to the facilitation of both osteoblast and adipocyte differentiation.
33559665	5	83	dep	mobility	1020:1027	arg1	the					1006:1008	the	1006:1008	the	1006:1008	The contact angle hysteresis reflecting the molecular mobility and zeta potential of each polyrotaxane surface changed depending on the functional groups.
34232652	7	0	theme	biological	1041:1050	arg1	variability					1052:1062	the observed biological variability	1028:1062	the observed biological variability	1028:1062	Contributing factors to the observed biological variability were goat age, parity, lifetime milk production, and the kids' sex.
34232652	3	1	theme	milk	444:447	arg1	production					449:458	lifetime milk production	435:458	lifetime milk production	435:458	Potential correlations with factors such as age, parity, and lifetime milk production were examined.
34232652	2	2	from	colostrum	265:273	arg1	gMOS					254:257	gMOS	254:257	gMOS	254:257	We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate.
34232652	2	2	from	colostrum	265:273	arg1	composition					229:239	the composition	225:239	the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation	225:306	We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate.
34232652	2	2	from	colostrum	265:273	arg1	MOS					249:251	goat MOS	244:251	goat MOS (gMOS) from colostrum	244:273	We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate.
34232652	4	3	theme	liquid	542:547	arg1	chromatography					549:562	ultra-high-performance liquid chromatography	519:562	ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis	519:616	An effective method for gMOS extraction and ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis was established, following 2-aminobenzamide gMOS labeling.
34232652	4	3	theme	liquid	542:547	arg1	UPLC-FLD					599:606	UPLC-FLD	599:606	UPLC-FLD	599:606	An effective method for gMOS extraction and ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis was established, following 2-aminobenzamide gMOS labeling.
34232652	8	4	theme	in	1213:1214	arg1	variations					1202:1211	variations in	1202:1214	variations in	1202:1214	The results significantly contribute to the current understanding of (variations in) gMOS composition.
34232652	8	4	theme	in	1213:1214	arg1	composition					1222:1232	(variations in) gMOS composition	1201:1232	(variations in) gMOS composition	1201:1232	The results significantly contribute to the current understanding of (variations in) gMOS composition.
34232652	6	5	attach	present	869:875	arg1	%					884:884	73.7%	880:884	73.7% of the milk samples analyzed	880:913	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	6	5	attach	present	869:875	arg2	2'-fucosyllactose					847:863	2'-fucosyllactose	847:863	2'-fucosyllactose	847:863	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	6	5	attach	present	869:875	arg1	samples					898:904	the milk samples	889:904	the milk samples analyzed	889:913	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	4	6	theme	ultra-high-performance	519:540	arg1	chromatography					549:562	ultra-high-performance liquid chromatography	519:562	ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis	519:616	An effective method for gMOS extraction and ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis was established, following 2-aminobenzamide gMOS labeling.
34232652	4	6	theme	ultra-high-performance	519:540	arg1	UPLC-FLD					599:606	UPLC-FLD	599:606	UPLC-FLD	599:606	An effective method for gMOS extraction and ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis was established, following 2-aminobenzamide gMOS labeling.
34232652	5	7	from	structures	783:792	arg1	samples					817:823	the individual milk samples	797:823	the individual milk samples	797:823	Considerable biological variability was highlighted among the 12 quantified gMOS and the 9 non-quantified structures in the individual milk samples.
34232652	6	8	from	%	884:884	arg1	present					869:875	present	869:875	present	869:875	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	6	9	theme	milk	893:896	arg1	samples					898:904	the milk samples	889:904	the milk samples analyzed	889:913	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	6	10	theme	similar	985:991	arg1	genotype					975:982	a secretor/non-secretor goat genotype	946:982	a secretor/non-secretor goat genotype	946:982	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	1	11	theme	Human	129:133	arg1	oligosaccharides					140:155	Human milk oligosaccharides	129:155	Human milk oligosaccharides (hMOS)	129:162	Human milk oligosaccharides (hMOS) are associated with health benefits for newborns.
34232652	1	11	theme	Human	129:133	arg1	hMOS					158:161	hMOS	158:161	hMOS	158:161	Human milk oligosaccharides (hMOS) are associated with health benefits for newborns.
34232652	7	12	theme	milk	1096:1099	arg1	production					1101:1110	lifetime milk production	1087:1110	lifetime milk production	1087:1110	Contributing factors to the observed biological variability were goat age, parity, lifetime milk production, and the kids' sex.
34232652	4	13	theme	2-aminobenzamide	645:660	arg1	labeling					667:674	2-aminobenzamide gMOS labeling	645:674	2-aminobenzamide gMOS labeling	645:674	An effective method for gMOS extraction and ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis was established, following 2-aminobenzamide gMOS labeling.
34232652	2	14	theme	present	350:356	arg1	structures					339:348	the structures	335:348	the structures present and their fate	335:371	We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate.
34232652	4	15	theme	chromatography	549:562	arg1	analysis					609:616	ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis	519:616	ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis	519:616	An effective method for gMOS extraction and ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis was established, following 2-aminobenzamide gMOS labeling.
34232652	5	16	theme	non-quantified	768:781	arg1	structures					783:792	the 9 non-quantified structures	762:792	the 9 non-quantified structures	762:792	Considerable biological variability was highlighted among the 12 quantified gMOS and the 9 non-quantified structures in the individual milk samples.
34232652	2	17	theme	structures	339:348	arg1	overview					323:330	an overview	320:330	an overview of the structures present and their fate	320:371	We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate.
34232652	5	18	theme	individual	801:810	arg1	samples					817:823	the individual milk samples	797:823	the individual milk samples	797:823	Considerable biological variability was highlighted among the 12 quantified gMOS and the 9 non-quantified structures in the individual milk samples.
34232652	2	19	dep	month	289:293	arg1	up					275:276	up	275:276	up	275:276	We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate.
34232652	3	20	theme	Potential	374:382	arg1	correlations					384:395	Potential correlations	374:395	Potential correlations with factors such as age, parity, and lifetime milk production	374:458	Potential correlations with factors such as age, parity, and lifetime milk production were examined.
34232652	5	21	theme	milk	812:815	arg1	samples					817:823	the individual milk samples	797:823	the individual milk samples	797:823	Considerable biological variability was highlighted among the 12 quantified gMOS and the 9 non-quantified structures in the individual milk samples.
34232652	4	22	theme	gMOS	499:502	arg1	extraction					504:513	gMOS extraction	499:513	gMOS extraction	499:513	An effective method for gMOS extraction and ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis was established, following 2-aminobenzamide gMOS labeling.
34232652	7	23	theme	lifetime	1087:1094	arg1	production					1101:1110	lifetime milk production	1087:1110	lifetime milk production	1087:1110	Contributing factors to the observed biological variability were goat age, parity, lifetime milk production, and the kids' sex.
34232652	6	24	from	present	869:875	arg1	%					884:884	73.7%	880:884	73.7% of the milk samples analyzed	880:913	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	6	24	from	present	869:875	arg1	samples					898:904	the milk samples	889:904	the milk samples analyzed	889:913	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	6	25	theme	genotype	975:982	arg1	possibility					931:941	the possibility	927:941	the possibility of a secretor/non-secretor goat genotype, similar to humans	927:1001	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	5	26	theme	biological	690:699	arg1	variability					701:711	Considerable biological variability	677:711	Considerable biological variability	677:711	Considerable biological variability was highlighted among the 12 quantified gMOS and the 9 non-quantified structures in the individual milk samples.
34232652	0	27	dep	Composition	68:78	arg1	Extraction					0:9	Extraction	0:9	Extraction	0:9	Extraction and Quantitative Analysis of Goat Milk Oligosaccharides: Composition, Variation, Associations, and 2'-FL Variability.
34232652	0	27	dep	Composition	68:78	arg1	Analysis					28:35	Quantitative Analysis	15:35	Quantitative Analysis of Goat Milk Oligosaccharides	15:65	Extraction and Quantitative Analysis of Goat Milk Oligosaccharides: Composition, Variation, Associations, and 2'-FL Variability.
34232652	2	28	from	composition	229:239	arg1	colostrum					265:273	colostrum	265:273	colostrum	265:273	We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate.
34232652	1	29	theme	health	184:189	arg1	benefits					191:198	health benefits	184:198	health benefits for newborns	184:211	Human milk oligosaccharides (hMOS) are associated with health benefits for newborns.
34232652	0	30	theme	Quantitative	15:26	arg1	Analysis					28:35	Quantitative Analysis	15:35	Quantitative Analysis of Goat Milk Oligosaccharides	15:65	Extraction and Quantitative Analysis of Goat Milk Oligosaccharides: Composition, Variation, Associations, and 2'-FL Variability.
34232652	6	31	theme	goat	970:973	arg1	genotype					975:982	a secretor/non-secretor goat genotype	946:982	a secretor/non-secretor goat genotype	946:982	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	0	32	theme	2'-FL	110:114	arg1	Variability					116:126	2'-FL Variability	110:126	2'-FL Variability	110:126	Extraction and Quantitative Analysis of Goat Milk Oligosaccharides: Composition, Variation, Associations, and 2'-FL Variability.
34232652	6	33	located	present	869:875	arg1	%					884:884	73.7%	880:884	73.7% of the milk samples analyzed	880:913	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	6	33	located	present	869:875	arg2	2'-fucosyllactose					847:863	2'-fucosyllactose	847:863	2'-fucosyllactose	847:863	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	6	33	located	present	869:875	arg1	samples					898:904	the milk samples	889:904	the milk samples analyzed	889:913	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	2	34	theme	fate	368:371	arg1	structures					339:348	the structures	335:348	the structures present and their fate	335:371	We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate.
34232652	0	35	theme	Goat	40:43	arg1	Oligosaccharides					50:65	Goat Milk Oligosaccharides	40:65	Goat Milk Oligosaccharides	40:65	Extraction and Quantitative Analysis of Goat Milk Oligosaccharides: Composition, Variation, Associations, and 2'-FL Variability.
34232652	6	36	theme	secretor/non-secretor	948:968	arg1	genotype					975:982	a secretor/non-secretor goat genotype	946:982	a secretor/non-secretor goat genotype	946:982	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	7	37	theme	goat	1069:1072	arg1	age					1074:1076	goat age	1069:1076	goat age	1069:1076	Contributing factors to the observed biological variability were goat age, parity, lifetime milk production, and the kids' sex.
34232652	8	38	theme	current	1176:1182	arg1	understanding					1184:1196	the current understanding	1172:1196	the current understanding of (variations in) gMOS composition	1172:1232	The results significantly contribute to the current understanding of (variations in) gMOS composition.
34232652	8	39	theme	composition	1222:1232	arg1	understanding					1184:1196	the current understanding	1172:1196	the current understanding of (variations in) gMOS composition	1172:1232	The results significantly contribute to the current understanding of (variations in) gMOS composition.
34232652	5	40	theme	quantified	742:751	arg1	gMOS					753:756	the 12 quantified gMOS	735:756	the 12 quantified gMOS	735:756	Considerable biological variability was highlighted among the 12 quantified gMOS and the 9 non-quantified structures in the individual milk samples.
34232652	0	41	theme	Oligosaccharides	50:65	arg1	Extraction					0:9	Extraction	0:9	Extraction	0:9	Extraction and Quantitative Analysis of Goat Milk Oligosaccharides: Composition, Variation, Associations, and 2'-FL Variability.
34232652	0	41	theme	Oligosaccharides	50:65	arg1	Analysis					28:35	Quantitative Analysis	15:35	Quantitative Analysis of Goat Milk Oligosaccharides	15:65	Extraction and Quantitative Analysis of Goat Milk Oligosaccharides: Composition, Variation, Associations, and 2'-FL Variability.
34232652	2	42	theme	lactation	298:306	arg1	month					289:293	the 9th month	281:293	the 9th month of lactation	281:306	We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate.
34232652	0	43	theme	Milk	45:48	arg1	Oligosaccharides					50:65	Goat Milk Oligosaccharides	40:65	Goat Milk Oligosaccharides	40:65	Extraction and Quantitative Analysis of Goat Milk Oligosaccharides: Composition, Variation, Associations, and 2'-FL Variability.
34232652	3	44	with	correlations	384:395	arg1	production					449:458	lifetime milk production	435:458	lifetime milk production	435:458	Potential correlations with factors such as age, parity, and lifetime milk production were examined.
34232652	3	44	with	correlations	384:395	arg1	parity					423:428	parity	423:428	parity	423:428	Potential correlations with factors such as age, parity, and lifetime milk production were examined.
34232652	3	44	with	correlations	384:395	arg1	factors					402:408	factors	402:408	factors such as age, parity, and lifetime milk production	402:458	Potential correlations with factors such as age, parity, and lifetime milk production were examined.
34232652	3	44	with	correlations	384:395	arg1	age					418:420	age	418:420	age	418:420	Potential correlations with factors such as age, parity, and lifetime milk production were examined.
34232652	7	45	theme	Contributing	1004:1015	arg1	factors					1017:1023	Contributing factors	1004:1023	Contributing factors to the observed biological variability	1004:1062	Contributing factors to the observed biological variability were goat age, parity, lifetime milk production, and the kids' sex.
34232652	3	46	theme	lifetime	435:442	arg1	production					449:458	lifetime milk production	435:458	lifetime milk production	435:458	Potential correlations with factors such as age, parity, and lifetime milk production were examined.
34232652	4	47	theme	effective	478:486	arg1	method					488:493	An effective method	475:493	An effective method for gMOS extraction and ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis	475:616	An effective method for gMOS extraction and ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis was established, following 2-aminobenzamide gMOS labeling.
34232652	7	48	theme	observed	1032:1039	arg1	variability					1052:1062	the observed biological variability	1028:1062	the observed biological variability	1028:1062	Contributing factors to the observed biological variability were goat age, parity, lifetime milk production, and the kids' sex.
34232652	2	49	theme	MOS	249:251	arg1	composition					229:239	the composition	225:239	the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation	225:306	We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate.
34232652	4	50	theme	fluorescence	575:586	arg1	detection					588:596	fluorescence detection	575:596	fluorescence detection	575:596	An effective method for gMOS extraction and ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis was established, following 2-aminobenzamide gMOS labeling.
34232652	5	51	theme	Considerable	677:688	arg1	variability					701:711	Considerable biological variability	677:711	Considerable biological variability	677:711	Considerable biological variability was highlighted among the 12 quantified gMOS and the 9 non-quantified structures in the individual milk samples.
34232652	5	52	from	gMOS	753:756	arg1	samples					817:823	the individual milk samples	797:823	the individual milk samples	797:823	Considerable biological variability was highlighted among the 12 quantified gMOS and the 9 non-quantified structures in the individual milk samples.
34232652	2	53	theme	goat	244:247	arg1	gMOS					254:257	gMOS	254:257	gMOS	254:257	We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate.
34232652	2	53	theme	goat	244:247	arg1	MOS					249:251	goat MOS	244:251	goat MOS (gMOS) from colostrum	244:273	We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate.
34232652	2	54	theme	9th	285:287	arg1	month					289:293	the 9th month	281:293	the 9th month of lactation	281:306	We studied the composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation to conceive an overview of the structures present and their fate.
34232652	1	55	theme	milk	135:138	arg1	oligosaccharides					140:155	Human milk oligosaccharides	129:155	Human milk oligosaccharides (hMOS)	129:162	Human milk oligosaccharides (hMOS) are associated with health benefits for newborns.
34232652	1	55	theme	milk	135:138	arg1	hMOS					158:161	hMOS	158:161	hMOS	158:161	Human milk oligosaccharides (hMOS) are associated with health benefits for newborns.
34232652	8	56	theme	gMOS	1217:1220	arg1	variations					1202:1211	variations in	1202:1214	variations in	1202:1214	The results significantly contribute to the current understanding of (variations in) gMOS composition.
34232652	8	56	theme	gMOS	1217:1220	arg1	composition					1222:1232	(variations in) gMOS composition	1201:1232	(variations in) gMOS composition	1201:1232	The results significantly contribute to the current understanding of (variations in) gMOS composition.
34232652	6	57	theme	samples	898:904	arg1	%					884:884	73.7%	880:884	73.7% of the milk samples analyzed	880:913	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	6	57	theme	samples	898:904	arg1	samples					898:904	the milk samples	889:904	the milk samples analyzed	889:913	Most characteristic, 2'-fucosyllactose was present in 73.7% of the milk samples analyzed, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
34232652	4	58	theme	gMOS	662:665	arg1	labeling					667:674	2-aminobenzamide gMOS labeling	645:674	2-aminobenzamide gMOS labeling	645:674	An effective method for gMOS extraction and ultra-high-performance liquid chromatography coupled to fluorescence detection (UPLC-FLD) analysis was established, following 2-aminobenzamide gMOS labeling.
32299661	5	0	theme	C-H	826:828	arg1	C-19					852:855	C-19	852:855	C-19	852:855	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	0	theme	C-H	826:828	arg1	C-11					846:849	C-11	846:849	C-11	846:849	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	0	theme	C-H	826:828	arg1	bonds					830:834	the unactivated C-H bonds	810:834	the unactivated C-H bonds including C-11, C-19 and C-27	810:864	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	0	theme	C-H	826:828	arg1	C-27					861:864	C-27	861:864	C-27	861:864	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	7	1	theme	significant	1229:1239	arg1	effect					1252:1257	significant inhibitory effect	1229:1257	significant inhibitory effect	1229:1257	Among them, olean-12-ene-3β,7β,15α,19α,30-pentol (16) and olean-12-ene-3β,7β,15α,27,30-pentol (17) showed significant inhibitory effect with IC50 values of 0.64 and 0.07 μM, respectively.
32299661	5	2	theme	reactions	724:732	arg1	glycosylation					781:793	glycosylation	781:793	glycosylation	781:793	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	2	theme	reactions	724:732	arg1	hydroxylation					763:775	hydroxylation	763:775	hydroxylation	763:775	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	2	theme	reactions	724:732	arg1	types					715:719	Two main types	706:719	Two main types of reactions	706:732	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	3	theme	biotransformation	888:904	arg1	process					906:912	the biotransformation process	884:912	the biotransformation process	884:912	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	6	4	theme	-stimulated	1094:1104	arg1	cells					1116:1120	lipopolysaccharide (LPS)-stimulated RAW 264.7 cells	1070:1120	lipopolysaccharide (LPS)-stimulated RAW 264.7 cells	1070:1120	All compounds were tested for their inhibitory effects on nitric oxide (NO) generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
32299661	5	5	theme	GA	964:965	arg1	derivatives					967:977	GA derivatives	964:977	GA derivatives	964:977	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	6	theme	main	710:713	arg1	glycosylation					781:793	glycosylation	781:793	glycosylation	781:793	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	6	theme	main	710:713	arg1	hydroxylation					763:775	hydroxylation	763:775	hydroxylation	763:775	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	6	theme	main	710:713	arg1	types					715:719	Two main types	706:719	Two main types of reactions	706:732	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	7	theme	chemical	940:947	arg1	diversities					949:959	the chemical diversities	936:959	the chemical diversities of GA derivatives	936:977	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	6	8	from	generation	1056:1065	arg1	cells					1116:1120	lipopolysaccharide (LPS)-stimulated RAW 264.7 cells	1070:1120	lipopolysaccharide (LPS)-stimulated RAW 264.7 cells	1070:1120	All compounds were tested for their inhibitory effects on nitric oxide (NO) generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
32299661	1	9	theme	vital	245:249	arg1	role					251:254	a vital role	243:254	a vital role	243:254	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	0	10	theme	Bacillus	95:102	arg1	1.1741					121:126	Bacillus megaterium CGMCC 1.1741	95:126	Bacillus megaterium CGMCC 1.1741	95:126	Microbial transformation of glycyrrhetinic acid derivatives by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	7	11	theme	inhibitory	1241:1250	arg1	effect					1252:1257	significant inhibitory effect	1229:1257	significant inhibitory effect	1229:1257	Among them, olean-12-ene-3β,7β,15α,19α,30-pentol (16) and olean-12-ene-3β,7β,15α,27,30-pentol (17) showed significant inhibitory effect with IC50 values of 0.64 and 0.07 μM, respectively.
32299661	5	12	theme	stereo-selective	746:761	arg1	hydroxylation					763:775	hydroxylation	763:775	hydroxylation	763:775	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	12	theme	stereo-selective	746:761	arg1	types					715:719	Two main types	706:719	Two main types of reactions	706:732	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	2	13	theme	GA	366:367	arg1	derivatives					369:379	five GA derivatives	361:379	five GA derivatives	361:379	In this study, we semi-synthesized five GA derivatives by a series of chemical reactions.
32299661	1	14	theme	major	159:163	arg1	acid					144:147	Glycyrrhetinic acid	129:147	Glycyrrhetinic acid (GA)	129:152	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	1	14	theme	major	159:163	arg1	aglycone					198:205	the major bioactive pentacyclic triterpene aglycone	155:205	the major bioactive pentacyclic triterpene aglycone of licorice root	155:222	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	0	15	theme	CGMCC	115:119	arg1	1.1741					121:126	Bacillus megaterium CGMCC 1.1741	95:126	Bacillus megaterium CGMCC 1.1741	95:126	Microbial transformation of glycyrrhetinic acid derivatives by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	6	16	from	effects	1027:1033	arg1	generation					1056:1065	nitric oxide (NO) generation	1038:1065	nitric oxide (NO) generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells	1038:1120	All compounds were tested for their inhibitory effects on nitric oxide (NO) generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
32299661	0	17	dep	Bacillus	95:102	arg1	megaterium					104:113	megaterium	104:113	megaterium	104:113	Microbial transformation of glycyrrhetinic acid derivatives by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	1	18	theme	bioactive	165:173	arg1	acid					144:147	Glycyrrhetinic acid	129:147	Glycyrrhetinic acid (GA)	129:152	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	1	18	theme	bioactive	165:173	arg1	aglycone					198:205	the major bioactive pentacyclic triterpene aglycone	155:205	the major bioactive pentacyclic triterpene aglycone of licorice root	155:222	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	5	19	located	observed	872:879	arg2	hydroxylation					763:775	hydroxylation	763:775	hydroxylation	763:775	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	19	located	observed	872:879	arg1	process					906:912	the biotransformation process	884:912	the biotransformation process	884:912	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	19	located	observed	872:879	arg2	types					715:719	Two main types	706:719	Two main types of reactions	706:732	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	19	located	observed	872:879	arg2	glycosylation					781:793	glycosylation	781:793	glycosylation	781:793	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	3	20	theme	CGMCC	563:567	arg1	1.1741					569:574	Bacillus megaterium CGMCC 1.1741	543:574	Bacillus megaterium CGMCC 1.1741	543:574	They were selected as substrates for the biotransformation and yielded thirteen metabolites by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	1	21	theme	pentacyclic	175:185	arg1	acid					144:147	Glycyrrhetinic acid	129:147	Glycyrrhetinic acid (GA)	129:152	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	1	21	theme	pentacyclic	175:185	arg1	aglycone					198:205	the major bioactive pentacyclic triterpene aglycone	155:205	the major bioactive pentacyclic triterpene aglycone of licorice root	155:222	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	0	22	theme	Microbial	0:8	arg1	transformation					10:23	Microbial transformation	0:23	Microbial transformation of glycyrrhetinic acid derivatives by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.	0:127	Microbial transformation of glycyrrhetinic acid derivatives by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	7	23	theme	0.07 μM	1288:1294	arg1	values					1269:1274	IC50 values	1264:1274	IC50 values	1264:1274	Among them, olean-12-ene-3β,7β,15α,19α,30-pentol (16) and olean-12-ene-3β,7β,15α,27,30-pentol (17) showed significant inhibitory effect with IC50 values of 0.64 and 0.07 μM, respectively.
32299661	1	24	theme	triterpene	187:196	arg1	acid					144:147	Glycyrrhetinic acid	129:147	Glycyrrhetinic acid (GA)	129:152	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	1	24	theme	triterpene	187:196	arg1	aglycone					198:205	the major bioactive pentacyclic triterpene aglycone	155:205	the major bioactive pentacyclic triterpene aglycone of licorice root	155:222	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	0	25	theme	glycyrrhetinic	28:41	arg1	derivatives					48:58	glycyrrhetinic acid derivatives	28:58	glycyrrhetinic acid derivatives	28:58	Microbial transformation of glycyrrhetinic acid derivatives by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	3	26	theme	Bacillus	543:550	arg1	1.1741					569:574	Bacillus megaterium CGMCC 1.1741	543:574	Bacillus megaterium CGMCC 1.1741	543:574	They were selected as substrates for the biotransformation and yielded thirteen metabolites by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	2	27	theme	chemical	396:403	arg1	reactions					405:413	chemical reactions	396:413	chemical reactions	396:413	In this study, we semi-synthesized five GA derivatives by a series of chemical reactions.
32299661	2	28	theme	reactions	405:413	arg1	series					386:391	a series	384:391	a series of chemical reactions	384:413	In this study, we semi-synthesized five GA derivatives by a series of chemical reactions.
32299661	3	29	dep	Bacillus	511:518	arg1	subtilis					520:527	subtilis	520:527	subtilis	520:527	They were selected as substrates for the biotransformation and yielded thirteen metabolites by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	0	30	theme	derivatives	48:58	arg1	transformation					10:23	Microbial transformation	0:23	Microbial transformation of glycyrrhetinic acid derivatives by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.	0:127	Microbial transformation of glycyrrhetinic acid derivatives by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	4	31	theme	them	670:673	arg1	nine					662:665	nine	662:665	nine	662:665	Their structures were identified on the basis of extensive spectroscopic methods and nine of them were found for the first time.
32299661	4	31	theme	them	670:673	arg1	them					670:673	them	670:673	them	670:673	Their structures were identified on the basis of extensive spectroscopic methods and nine of them were found for the first time.
32299661	4	32	theme	methods	650:656	arg1	basis					617:621	the basis	613:621	the basis of extensive spectroscopic methods	613:656	Their structures were identified on the basis of extensive spectroscopic methods and nine of them were found for the first time.
32299661	0	33	dep	Bacillus	63:70	arg1	subtilis					72:79	subtilis	72:79	subtilis	72:79	Microbial transformation of glycyrrhetinic acid derivatives by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	6	34	theme	oxide	1045:1049	arg1	generation					1056:1065	nitric oxide (NO) generation	1038:1065	nitric oxide (NO) generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells	1038:1120	All compounds were tested for their inhibitory effects on nitric oxide (NO) generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
32299661	1	35	theme	licorice	210:217	arg1	root					219:222	licorice root	210:222	licorice root	210:222	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	0	36	theme	acid	43:46	arg1	derivatives					48:58	glycyrrhetinic acid derivatives	28:58	glycyrrhetinic acid derivatives	28:58	Microbial transformation of glycyrrhetinic acid derivatives by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	1	37	theme	root	219:222	arg1	acid					144:147	Glycyrrhetinic acid	129:147	Glycyrrhetinic acid (GA)	129:152	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	1	37	theme	root	219:222	arg1	aglycone					198:205	the major bioactive pentacyclic triterpene aglycone	155:205	the major bioactive pentacyclic triterpene aglycone of licorice root	155:222	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	0	38	theme	Bacillus	63:70	arg1	6633					86:89	Bacillus subtilis ATCC 6633	63:89	Bacillus subtilis ATCC 6633	63:89	Microbial transformation of glycyrrhetinic acid derivatives by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	6	39	theme	inhibitory	1016:1025	arg1	effects					1027:1033	their inhibitory effects	1010:1033	their inhibitory effects on nitric oxide (NO) generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells	1010:1120	All compounds were tested for their inhibitory effects on nitric oxide (NO) generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
32299661	5	40	from	types	715:719	arg1	C-19					852:855	C-19	852:855	C-19	852:855	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	40	from	types	715:719	arg1	C-11					846:849	C-11	846:849	C-11	846:849	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	40	from	types	715:719	arg1	bonds					830:834	the unactivated C-H bonds	810:834	the unactivated C-H bonds including C-11, C-19 and C-27	810:864	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	40	from	types	715:719	arg1	C-27					861:864	C-27	861:864	C-27	861:864	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	6	41	theme	RAW	1106:1108	arg1	cells					1116:1120	lipopolysaccharide (LPS)-stimulated RAW 264.7 cells	1070:1120	lipopolysaccharide (LPS)-stimulated RAW 264.7 cells	1070:1120	All compounds were tested for their inhibitory effects on nitric oxide (NO) generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
32299661	1	42	theme	Glycyrrhetinic	129:142	arg1	acid					144:147	Glycyrrhetinic acid	129:147	Glycyrrhetinic acid (GA)	129:152	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	1	42	theme	Glycyrrhetinic	129:142	arg1	aglycone					198:205	the major bioactive pentacyclic triterpene aglycone	155:205	the major bioactive pentacyclic triterpene aglycone of licorice root	155:222	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	1	42	theme	Glycyrrhetinic	129:142	arg1	GA					150:151	GA	150:151	GA	150:151	Glycyrrhetinic acid (GA), the major bioactive pentacyclic triterpene aglycone of licorice root, was known to play a vital role in anti-ulcer, anti-depressant, anti-inflammatory, and anti-allergic.
32299661	5	43	theme	derivatives	967:977	arg1	diversities					949:959	the chemical diversities	936:959	the chemical diversities of GA derivatives	936:977	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	7	44	theme	IC50	1264:1267	arg1	values					1269:1274	IC50 values	1264:1274	IC50 values	1264:1274	Among them, olean-12-ene-3β,7β,15α,19α,30-pentol (16) and olean-12-ene-3β,7β,15α,27,30-pentol (17) showed significant inhibitory effect with IC50 values of 0.64 and 0.07 μM, respectively.
32299661	3	45	theme	ATCC	529:532	arg1	6633					534:537	Bacillus subtilis ATCC 6633	511:537	Bacillus subtilis ATCC 6633	511:537	They were selected as substrates for the biotransformation and yielded thirteen metabolites by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	7	46	theme	0.64	1279:1282	arg1	values					1269:1274	IC50 values	1264:1274	IC50 values	1264:1274	Among them, olean-12-ene-3β,7β,15α,19α,30-pentol (16) and olean-12-ene-3β,7β,15α,27,30-pentol (17) showed significant inhibitory effect with IC50 values of 0.64 and 0.07 μM, respectively.
32299661	6	47	theme	nitric	1038:1043	arg1	NO					1052:1053	NO	1052:1053	NO	1052:1053	All compounds were tested for their inhibitory effects on nitric oxide (NO) generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
32299661	6	47	theme	nitric	1038:1043	arg1	oxide					1045:1049	nitric oxide	1038:1049	nitric oxide (NO) generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells	1038:1120	All compounds were tested for their inhibitory effects on nitric oxide (NO) generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
32299661	0	48	theme	ATCC	81:84	arg1	6633					86:89	Bacillus subtilis ATCC 6633	63:89	Bacillus subtilis ATCC 6633	63:89	Microbial transformation of glycyrrhetinic acid derivatives by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	4	49	theme	spectroscopic	636:648	arg1	methods					650:656	extensive spectroscopic methods	626:656	extensive spectroscopic methods	626:656	Their structures were identified on the basis of extensive spectroscopic methods and nine of them were found for the first time.
32299661	4	50	theme	extensive	626:634	arg1	methods					650:656	extensive spectroscopic methods	626:656	extensive spectroscopic methods	626:656	Their structures were identified on the basis of extensive spectroscopic methods and nine of them were found for the first time.
32299661	3	51	dep	Bacillus	543:550	arg1	megaterium					552:561	megaterium	552:561	megaterium	552:561	They were selected as substrates for the biotransformation and yielded thirteen metabolites by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	5	52	theme	regio-	735:740	arg1	hydroxylation					763:775	hydroxylation	763:775	hydroxylation	763:775	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	52	theme	regio-	735:740	arg1	types					715:719	Two main types	706:719	Two main types of reactions	706:732	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	53	theme	unactivated	814:824	arg1	C-19					852:855	C-19	852:855	C-19	852:855	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	53	theme	unactivated	814:824	arg1	C-11					846:849	C-11	846:849	C-11	846:849	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	53	theme	unactivated	814:824	arg1	bonds					830:834	the unactivated C-H bonds	810:834	the unactivated C-H bonds including C-11, C-19 and C-27	810:864	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	5	53	theme	unactivated	814:824	arg1	C-27					861:864	C-27	861:864	C-27	861:864	Two main types of reactions, regio- and stereo-selective hydroxylation and glycosylation, especially in the unactivated C-H bonds including C-11, C-19 and C-27, were observed in the biotransformation process, which greatly expand the chemical diversities of GA derivatives.
32299661	3	54	theme	Bacillus	511:518	arg1	6633					534:537	Bacillus subtilis ATCC 6633	511:537	Bacillus subtilis ATCC 6633	511:537	They were selected as substrates for the biotransformation and yielded thirteen metabolites by Bacillus subtilis ATCC 6633 and Bacillus megaterium CGMCC 1.1741.
32299661	4	55	theme	first	694:698	arg1	time					700:703	the first time	690:703	the first time	690:703	Their structures were identified on the basis of extensive spectroscopic methods and nine of them were found for the first time.
34702510	1	0	theme	polyvinyl	170:178	arg1	alcohol					180:186	polyvinyl alcohol	170:186	polyvinyl alcohol	170:186	We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW).
34702510	1	1	theme	ink	270:272	arg1	writing					274:280	direct ink writing	263:280	direct ink writing (DIW)	263:286	We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW).
34702510	1	1	theme	ink	270:272	arg1	DIW					283:285	DIW	283:285	DIW	283:285	We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW).
34702510	0	2	theme	printed	91:97	arg1	materials					99:107	3D printed materials	88:107	3D printed materials	88:107	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril hydrogels as precursors for 3D printed materials.
34702510	2	3	theme	rheology	350:357	arg1	profiles					359:366	rheology profiles	350:366	rheology profiles that were suitable for extrusion and solidification in pre-designed shapes	350:441	The presence of CNF in the aqueous PVA suspensions conferred rheology profiles that were suitable for extrusion and solidification in pre-designed shapes.
34702510	6	4	theme	efficient	1005:1013	arg1	delivery					1015:1022	a controlled and efficient delivery	988:1022	a controlled and efficient delivery of an antioxidant (ascorbic acid)	988:1056	As such, drug-loaded samples revealed a controlled and efficient delivery of an antioxidant (ascorbic acid) in PBS buffer media at 23 °C (~80% for 8 h).
34702510	7	5	theme	3D-lattice	1175:1184	arg1	geometries					1186:1195	3D-lattice geometries	1175:1195	3D-lattice geometries with excellent physical and mechanical characteristics	1175:1250	Altogether, PVA/CNF hydrogels were introduced as suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics.
34702510	6	6	dep	23 °C	1081:1085	arg1	%					1091:1091	~80%	1088:1091	~80% for 8 h	1088:1099	As such, drug-loaded samples revealed a controlled and efficient delivery of an antioxidant (ascorbic acid) in PBS buffer media at 23 °C (~80% for 8 h).
34702510	7	7	theme	geometries	1186:1195	arg1	precursors					1161:1170	suitable precursors	1152:1170	suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics	1152:1250	Altogether, PVA/CNF hydrogels were introduced as suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics.
34702510	7	7	theme	geometries	1186:1195	arg1	hydrogels					1123:1131	PVA/CNF hydrogels	1115:1131	PVA/CNF hydrogels	1115:1131	Altogether, PVA/CNF hydrogels were introduced as suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics.
34702510	4	8	theme	uptake	781:786	arg1	%					808:808	up to 1600%	798:808	up to 1600%	798:808	After lyophilization, the obtained 3D-printed hydrogels presented a very high porosity, with open and interconnected pores, allowing a high-water uptake capacity (up to 1600%).
34702510	4	8	theme	uptake	781:786	arg1	capacity					788:795	a high-water uptake capacity	768:795	a high-water uptake capacity (up to 1600%)	768:809	After lyophilization, the obtained 3D-printed hydrogels presented a very high porosity, with open and interconnected pores, allowing a high-water uptake capacity (up to 1600%).
34702510	3	9	theme	precise	497:503	arg1	control					505:511	precise control	497:511	precise control on processability and shape retention	497:549	The viscoelastic behavior of the hybrid inks enabled precise control on processability and shape retention, for instance, as demonstrated in multilayered lattice structures of high fidelity.
34702510	3	10	theme	inks	484:487	arg1	behavior					461:468	The viscoelastic behavior	444:468	The viscoelastic behavior of the hybrid inks	444:487	The viscoelastic behavior of the hybrid inks enabled precise control on processability and shape retention, for instance, as demonstrated in multilayered lattice structures of high fidelity.
34702510	6	11	theme	buffer	1065:1070	arg1	media					1072:1076	PBS buffer media	1061:1076	PBS buffer media	1061:1076	As such, drug-loaded samples revealed a controlled and efficient delivery of an antioxidant (ascorbic acid) in PBS buffer media at 23 °C (~80% for 8 h).
34702510	3	12	theme	viscoelastic	448:459	arg1	behavior					461:468	The viscoelastic behavior	444:468	The viscoelastic behavior of the hybrid inks	444:487	The viscoelastic behavior of the hybrid inks enabled precise control on processability and shape retention, for instance, as demonstrated in multilayered lattice structures of high fidelity.
34702510	6	13	theme	controlled	990:999	arg1	delivery					1015:1022	a controlled and efficient delivery	988:1022	a controlled and efficient delivery of an antioxidant (ascorbic acid)	988:1056	As such, drug-loaded samples revealed a controlled and efficient delivery of an antioxidant (ascorbic acid) in PBS buffer media at 23 °C (~80% for 8 h).
34702510	1	14	contain	containing	159:168	arg2	alcohol					180:186	polyvinyl alcohol	170:186	polyvinyl alcohol	170:186	We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW).
34702510	1	14	contain	containing	159:168	arg1	hydrogels					149:157	hydrogels	149:157	hydrogels containing polyvinyl alcohol	149:186	We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW).
34702510	1	15	dep	method	131:136	arg1	process					141:147	process	141:147	to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF)	138:222	We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW).
34702510	1	16	theme	cellulose	192:200	arg1	nanofibrils					202:212	cellulose nanofibrils	192:212	cellulose nanofibrils (PVA/CNF)	192:222	We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW).
34702510	1	16	theme	cellulose	192:200	arg1	PVA/CNF					215:221	PVA/CNF	215:221	PVA/CNF	215:221	We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW).
34702510	0	17	theme	acid-loaded	9:19	arg1	nanofibril					49:58	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril	0:58	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril	0:58	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril hydrogels as precursors for 3D printed materials.
34702510	7	18	theme	excellent	1202:1210	arg1	characteristics					1236:1250	excellent physical and mechanical characteristics	1202:1250	excellent physical and mechanical characteristics	1202:1250	Altogether, PVA/CNF hydrogels were introduced as suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics.
34702510	7	19	theme	physical	1212:1219	arg1	characteristics					1236:1250	excellent physical and mechanical characteristics	1202:1250	excellent physical and mechanical characteristics	1202:1250	Altogether, PVA/CNF hydrogels were introduced as suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics.
34702510	3	20	dep	processability	516:529	arg1	retention					541:549	retention	541:549	retention	541:549	The viscoelastic behavior of the hybrid inks enabled precise control on processability and shape retention, for instance, as demonstrated in multilayered lattice structures of high fidelity.
34702510	4	21	dep	1600	804:807	arg1	to					801:802	to	801:802	to	801:802	After lyophilization, the obtained 3D-printed hydrogels presented a very high porosity, with open and interconnected pores, allowing a high-water uptake capacity (up to 1600%).
34702510	0	22	theme	Ascorbic	0:7	arg1	nanofibril					49:58	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril	0:58	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril	0:58	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril hydrogels as precursors for 3D printed materials.
34702510	7	23	theme	mechanical	1225:1234	arg1	characteristics					1236:1250	excellent physical and mechanical characteristics	1202:1250	excellent physical and mechanical characteristics	1202:1250	Altogether, PVA/CNF hydrogels were introduced as suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics.
34702510	4	24	theme	interconnected	737:750	arg1	pores					752:756	open and interconnected pores	728:756	open and interconnected pores	728:756	After lyophilization, the obtained 3D-printed hydrogels presented a very high porosity, with open and interconnected pores, allowing a high-water uptake capacity (up to 1600%).
34702510	3	25	from	control	505:511	arg1	shape					535:539	shape	535:539	shape	535:539	The viscoelastic behavior of the hybrid inks enabled precise control on processability and shape retention, for instance, as demonstrated in multilayered lattice structures of high fidelity.
34702510	3	25	from	control	505:511	arg1	processability					516:529	processability	516:529	processability	516:529	The viscoelastic behavior of the hybrid inks enabled precise control on processability and shape retention, for instance, as demonstrated in multilayered lattice structures of high fidelity.
34702510	3	26	theme	multilayered	585:596	arg1	structures					606:615	multilayered lattice structures	585:615	multilayered lattice structures of high fidelity	585:632	The viscoelastic behavior of the hybrid inks enabled precise control on processability and shape retention, for instance, as demonstrated in multilayered lattice structures of high fidelity.
34702510	6	27	theme	PBS	1061:1063	arg1	media					1072:1076	PBS buffer media	1061:1076	PBS buffer media	1061:1076	As such, drug-loaded samples revealed a controlled and efficient delivery of an antioxidant (ascorbic acid) in PBS buffer media at 23 °C (~80% for 8 h).
34702510	0	28	theme	alcohol/cellulose	31:47	arg1	nanofibril					49:58	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril	0:58	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril	0:58	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril hydrogels as precursors for 3D printed materials.
34702510	7	29	with	geometries	1186:1195	arg1	characteristics					1236:1250	excellent physical and mechanical characteristics	1202:1250	excellent physical and mechanical characteristics	1202:1250	Altogether, PVA/CNF hydrogels were introduced as suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics.
34702510	2	30	theme	CNF	305:307	arg1	presence					293:300	The presence	289:300	The presence of CNF in the aqueous PVA suspensions	289:338	The presence of CNF in the aqueous PVA suspensions conferred rheology profiles that were suitable for extrusion and solidification in pre-designed shapes.
34702510	3	31	theme	hybrid	477:482	arg1	inks					484:487	the hybrid inks	473:487	the hybrid inks	473:487	The viscoelastic behavior of the hybrid inks enabled precise control on processability and shape retention, for instance, as demonstrated in multilayered lattice structures of high fidelity.
34702510	0	32	theme	polyvinyl	21:29	arg1	nanofibril					49:58	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril	0:58	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril	0:58	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril hydrogels as precursors for 3D printed materials.
34702510	5	33	theme	opening	905:911	arg1	tissues					896:902	soft tissues	891:902	soft tissues	891:902	The mechanical strength of the composite 3D-printed materials matched those of soft tissues, opening opportunities for skin applications.
34702510	5	33	theme	opening	905:911	arg1	opportunities					913:925	opening opportunities	905:925	opening opportunities for skin applications	905:947	The mechanical strength of the composite 3D-printed materials matched those of soft tissues, opening opportunities for skin applications.
34702510	2	34	theme	pre-designed	423:434	arg1	shapes					436:441	pre-designed shapes	423:441	pre-designed shapes	423:441	The presence of CNF in the aqueous PVA suspensions conferred rheology profiles that were suitable for extrusion and solidification in pre-designed shapes.
34702510	7	35	theme	PVA/CNF	1115:1121	arg1	precursors					1161:1170	suitable precursors	1152:1170	suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics	1152:1250	Altogether, PVA/CNF hydrogels were introduced as suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics.
34702510	7	35	theme	PVA/CNF	1115:1121	arg1	hydrogels					1123:1131	PVA/CNF hydrogels	1115:1131	PVA/CNF hydrogels	1115:1131	Altogether, PVA/CNF hydrogels were introduced as suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics.
34702510	6	36	theme	drug-loaded	959:969	arg1	samples					971:977	drug-loaded samples	959:977	drug-loaded samples	959:977	As such, drug-loaded samples revealed a controlled and efficient delivery of an antioxidant (ascorbic acid) in PBS buffer media at 23 °C (~80% for 8 h).
34702510	5	37	theme	composite	843:851	arg1	materials					864:872	the composite 3D-printed materials	839:872	the composite 3D-printed materials	839:872	The mechanical strength of the composite 3D-printed materials matched those of soft tissues, opening opportunities for skin applications.
34702510	4	38	theme	3D-printed	670:679	arg1	hydrogels					681:689	the obtained 3D-printed hydrogels	657:689	the obtained 3D-printed hydrogels	657:689	After lyophilization, the obtained 3D-printed hydrogels presented a very high porosity, with open and interconnected pores, allowing a high-water uptake capacity (up to 1600%).
34702510	5	39	theme	materials	864:872	arg1	strength					827:834	The mechanical strength	812:834	The mechanical strength of the composite 3D-printed materials	812:872	The mechanical strength of the composite 3D-printed materials matched those of soft tissues, opening opportunities for skin applications.
34702510	3	40	theme	high	620:623	arg1	fidelity					625:632	high fidelity	620:632	high fidelity	620:632	The viscoelastic behavior of the hybrid inks enabled precise control on processability and shape retention, for instance, as demonstrated in multilayered lattice structures of high fidelity.
34702510	4	41	theme	obtained	661:668	arg1	hydrogels					681:689	the obtained 3D-printed hydrogels	657:689	the obtained 3D-printed hydrogels	657:689	After lyophilization, the obtained 3D-printed hydrogels presented a very high porosity, with open and interconnected pores, allowing a high-water uptake capacity (up to 1600%).
34702510	2	42	attach	presence	293:300	arg1	suspensions					328:338	the aqueous PVA suspensions	312:338	the aqueous PVA suspensions	312:338	The presence of CNF in the aqueous PVA suspensions conferred rheology profiles that were suitable for extrusion and solidification in pre-designed shapes.
34702510	2	42	attach	presence	293:300	arg2	CNF					305:307	CNF	305:307	CNF	305:307	The presence of CNF in the aqueous PVA suspensions conferred rheology profiles that were suitable for extrusion and solidification in pre-designed shapes.
34702510	6	43	theme	ascorbic	1043:1050	arg1	antioxidant					1030:1040	an antioxidant	1027:1040	an antioxidant (ascorbic acid)	1027:1056	As such, drug-loaded samples revealed a controlled and efficient delivery of an antioxidant (ascorbic acid) in PBS buffer media at 23 °C (~80% for 8 h).
34702510	6	43	theme	ascorbic	1043:1050	arg1	acid					1052:1055	ascorbic acid	1043:1055	ascorbic acid	1043:1055	As such, drug-loaded samples revealed a controlled and efficient delivery of an antioxidant (ascorbic acid) in PBS buffer media at 23 °C (~80% for 8 h).
34702510	3	44	theme	lattice	598:604	arg1	structures					606:615	multilayered lattice structures	585:615	multilayered lattice structures of high fidelity	585:632	The viscoelastic behavior of the hybrid inks enabled precise control on processability and shape retention, for instance, as demonstrated in multilayered lattice structures of high fidelity.
34702510	1	45	theme	simple	124:129	arg1	method					131:136	a simple method	122:136	a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF)	122:222	We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW).
34702510	5	46	theme	mechanical	816:825	arg1	strength					827:834	The mechanical strength	812:834	The mechanical strength of the composite 3D-printed materials	812:872	The mechanical strength of the composite 3D-printed materials matched those of soft tissues, opening opportunities for skin applications.
34702510	4	47	theme	open	728:731	arg1	pores					752:756	open and interconnected pores	728:756	open and interconnected pores	728:756	After lyophilization, the obtained 3D-printed hydrogels presented a very high porosity, with open and interconnected pores, allowing a high-water uptake capacity (up to 1600%).
34702510	6	48	theme	antioxidant	1030:1040	arg1	delivery					1015:1022	a controlled and efficient delivery	988:1022	a controlled and efficient delivery of an antioxidant (ascorbic acid)	988:1056	As such, drug-loaded samples revealed a controlled and efficient delivery of an antioxidant (ascorbic acid) in PBS buffer media at 23 °C (~80% for 8 h).
34702510	2	49	from	extrusion	391:399	arg1	shapes					436:441	pre-designed shapes	423:441	pre-designed shapes	423:441	The presence of CNF in the aqueous PVA suspensions conferred rheology profiles that were suitable for extrusion and solidification in pre-designed shapes.
34702510	2	50	theme	PVA	324:326	arg1	suspensions					328:338	the aqueous PVA suspensions	312:338	the aqueous PVA suspensions	312:338	The presence of CNF in the aqueous PVA suspensions conferred rheology profiles that were suitable for extrusion and solidification in pre-designed shapes.
34702510	4	51	theme	high-water	770:779	arg1	%					808:808	up to 1600%	798:808	up to 1600%	798:808	After lyophilization, the obtained 3D-printed hydrogels presented a very high porosity, with open and interconnected pores, allowing a high-water uptake capacity (up to 1600%).
34702510	4	51	theme	high-water	770:779	arg1	capacity					788:795	a high-water uptake capacity	768:795	a high-water uptake capacity (up to 1600%)	768:809	After lyophilization, the obtained 3D-printed hydrogels presented a very high porosity, with open and interconnected pores, allowing a high-water uptake capacity (up to 1600%).
34702510	1	52	theme	volumetric	235:244	arg1	architectures					246:258	volumetric architectures	235:258	volumetric architectures	235:258	We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW).
34702510	2	53	theme	aqueous	316:322	arg1	suspensions					328:338	the aqueous PVA suspensions	312:338	the aqueous PVA suspensions	312:338	The presence of CNF in the aqueous PVA suspensions conferred rheology profiles that were suitable for extrusion and solidification in pre-designed shapes.
34702510	2	54	from	presence	293:300	arg1	suspensions					328:338	the aqueous PVA suspensions	312:338	the aqueous PVA suspensions	312:338	The presence of CNF in the aqueous PVA suspensions conferred rheology profiles that were suitable for extrusion and solidification in pre-designed shapes.
34702510	5	55	theme	skin	931:934	arg1	applications					936:947	skin applications	931:947	skin applications	931:947	The mechanical strength of the composite 3D-printed materials matched those of soft tissues, opening opportunities for skin applications.
34702510	0	56	theme	3D	88:89	arg1	materials					99:107	3D printed materials	88:107	3D printed materials	88:107	Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril hydrogels as precursors for 3D printed materials.
34702510	5	57	theme	3D-printed	853:862	arg1	materials					864:872	the composite 3D-printed materials	839:872	the composite 3D-printed materials	839:872	The mechanical strength of the composite 3D-printed materials matched those of soft tissues, opening opportunities for skin applications.
34702510	3	58	theme	fidelity	625:632	arg1	structures					606:615	multilayered lattice structures	585:615	multilayered lattice structures of high fidelity	585:632	The viscoelastic behavior of the hybrid inks enabled precise control on processability and shape retention, for instance, as demonstrated in multilayered lattice structures of high fidelity.
34702510	2	59	from	solidification	405:418	arg1	shapes					436:441	pre-designed shapes	423:441	pre-designed shapes	423:441	The presence of CNF in the aqueous PVA suspensions conferred rheology profiles that were suitable for extrusion and solidification in pre-designed shapes.
34702510	5	60	theme	soft	891:894	arg1	tissues					896:902	soft tissues	891:902	soft tissues	891:902	The mechanical strength of the composite 3D-printed materials matched those of soft tissues, opening opportunities for skin applications.
34702510	5	60	theme	soft	891:894	arg1	opportunities					913:925	opening opportunities	905:925	opening opportunities for skin applications	905:947	The mechanical strength of the composite 3D-printed materials matched those of soft tissues, opening opportunities for skin applications.
34702510	4	61	theme	high	708:711	arg1	porosity					713:720	a very high porosity	701:720	a very high porosity	701:720	After lyophilization, the obtained 3D-printed hydrogels presented a very high porosity, with open and interconnected pores, allowing a high-water uptake capacity (up to 1600%).
34702510	7	62	theme	suitable	1152:1159	arg1	precursors					1161:1170	suitable precursors	1152:1170	suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics	1152:1250	Altogether, PVA/CNF hydrogels were introduced as suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics.
34702510	7	62	theme	suitable	1152:1159	arg1	hydrogels					1123:1131	PVA/CNF hydrogels	1115:1131	PVA/CNF hydrogels	1115:1131	Altogether, PVA/CNF hydrogels were introduced as suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics.
34702510	1	63	theme	direct	263:268	arg1	writing					274:280	direct ink writing	263:280	direct ink writing (DIW)	263:286	We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW).
34702510	1	63	theme	direct	263:268	arg1	DIW					283:285	DIW	283:285	DIW	283:285	We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW).
32194102	9	0	theme	film	1265:1268	arg1	biocompatibility					1231:1246	the great biocompatibility	1221:1246	the great biocompatibility of QP-MMT hybrid film	1221:1268	The cytotoxicity assay was performed to prove the great biocompatibility of QP-MMT hybrid film.
32194102	3	1	dep	Fourier	366:372	arg1	transform					374:382	transform	374:382	transform infrared spectroscopy (FT-IR) and X-Ray diffraction (XRD)	374:440	The Fourier transform infrared spectroscopy (FT-IR) and X-Ray diffraction (XRD) were employed to determine the variation of the functional group and crystallinity between pectin and QP.
32194102	7	2	theme	sustained-release	959:975	arg1	performance					977:987	the sustained-release performance	955:987	the sustained-release performance	955:987	The in vitro drug release studies revealed that the MMT significantly improved the sustained-release performance in all simulated mediums.
32194102	8	3	from	half-hour	1097:1105	arg1	mediums					1124:1130	all simulated mediums	1110:1130	all simulated mediums	1110:1130	The cumulative release rate of sample QP10-MMT0.1 was all around 20% in the first half-hour in all simulated mediums and sustained increased for more than 8 h.
32194102	0	4	theme	drug	87:90	arg1	release					92:98	sustained drug release	77:98	sustained drug release	77:98	Design and preparation of quaternized pectin-Montmorillonite hybrid film for sustained drug release.
32194102	3	5	dep	transform	374:382	arg1	infrared					384:391	infrared	384:391	transform infrared spectroscopy (FT-IR) and X-Ray diffraction (XRD)	374:440	The Fourier transform infrared spectroscopy (FT-IR) and X-Ray diffraction (XRD) were employed to determine the variation of the functional group and crystallinity between pectin and QP.
32194102	6	6	theme	efficiency	823:832	arg1	%					840:840	36.50%	835:840	36.50%	835:840	The optimum film showed high value of drug encapsulation efficiency (36.50%) and loading efficiency (80.30%).
32194102	6	6	theme	efficiency	823:832	arg1	value					795:799	high value	790:799	high value of drug encapsulation efficiency (36.50%)	790:841	The optimum film showed high value of drug encapsulation efficiency (36.50%) and loading efficiency (80.30%).
32194102	6	6	theme	efficiency	823:832	arg1	efficiency					855:864	loading efficiency	847:864	loading efficiency (80.30%)	847:873	The optimum film showed high value of drug encapsulation efficiency (36.50%) and loading efficiency (80.30%).
32194102	6	6	theme	efficiency	823:832	arg1	%					872:872	80.30%	867:872	80.30%	867:872	The optimum film showed high value of drug encapsulation efficiency (36.50%) and loading efficiency (80.30%).
32194102	3	7	theme	functional	490:499	arg1	group					501:505	the functional group	486:505	the functional group	486:505	The Fourier transform infrared spectroscopy (FT-IR) and X-Ray diffraction (XRD) were employed to determine the variation of the functional group and crystallinity between pectin and QP.
32194102	4	8	theme	composite	562:570	arg1	film					572:575	The resultant composite film	548:575	The resultant composite film	548:575	The resultant composite film was characterized by FT-IR, XRD and Field Emission Scanning Electron Microscope.
32194102	9	9	theme	cytotoxicity	1179:1190	arg1	assay					1192:1196	The cytotoxicity assay	1175:1196	The cytotoxicity assay	1175:1196	The cytotoxicity assay was performed to prove the great biocompatibility of QP-MMT hybrid film.
32194102	8	10	dep	sustained	1136:1144	arg1	increased					1146:1154	increased	1146:1154	sustained increased for more than 8 h	1136:1172	The cumulative release rate of sample QP10-MMT0.1 was all around 20% in the first half-hour in all simulated mediums and sustained increased for more than 8 h.
32194102	6	11	theme	encapsulation	809:821	arg1	efficiency					823:832	drug encapsulation efficiency	804:832	drug encapsulation efficiency	804:832	The optimum film showed high value of drug encapsulation efficiency (36.50%) and loading efficiency (80.30%).
32194102	2	12	contain	containing	345:354	arg2	5-FU					356:359	5-FU	356:359	5-FU	356:359	To solve the limitation, the quaternized pectin (QP) was synthesized and firstly introduced to form QP-MMT hybrid film containing 5-FU.
32194102	2	12	contain	containing	345:354	arg1	film					340:343	QP-MMT hybrid film	326:343	QP-MMT hybrid film containing 5-FU	326:359	To solve the limitation, the quaternized pectin (QP) was synthesized and firstly introduced to form QP-MMT hybrid film containing 5-FU.
32194102	8	13	theme	release	1030:1036	arg1	all					1069:1071	all	1069:1071	all	1069:1071	The cumulative release rate of sample QP10-MMT0.1 was all around 20% in the first half-hour in all simulated mediums and sustained increased for more than 8 h.
32194102	8	13	theme	release	1030:1036	arg1	rate					1038:1041	The cumulative release rate	1015:1041	The cumulative release rate of sample QP10-MMT0.1	1015:1063	The cumulative release rate of sample QP10-MMT0.1 was all around 20% in the first half-hour in all simulated mediums and sustained increased for more than 8 h.
32194102	6	14	theme	drug	804:807	arg1	efficiency					823:832	drug encapsulation efficiency	804:832	drug encapsulation efficiency	804:832	The optimum film showed high value of drug encapsulation efficiency (36.50%) and loading efficiency (80.30%).
32194102	8	15	theme	sample	1046:1051	arg1	all					1069:1071	all	1069:1071	all	1069:1071	The cumulative release rate of sample QP10-MMT0.1 was all around 20% in the first half-hour in all simulated mediums and sustained increased for more than 8 h.
32194102	8	15	theme	sample	1046:1051	arg1	rate					1038:1041	The cumulative release rate	1015:1041	The cumulative release rate of sample QP10-MMT0.1	1015:1063	The cumulative release rate of sample QP10-MMT0.1 was all around 20% in the first half-hour in all simulated mediums and sustained increased for more than 8 h.
32194102	3	16	theme	crystallinity	511:523	arg1	variation					473:481	the variation	469:481	the variation of the functional group and crystallinity between pectin and QP	469:545	The Fourier transform infrared spectroscopy (FT-IR) and X-Ray diffraction (XRD) were employed to determine the variation of the functional group and crystallinity between pectin and QP.
32194102	1	17	theme	potential	184:192	arg1	use					194:196	the potential use	180:196	the potential use for sustained drug release	180:223	Montmorillonite (MMT) presents nonocclusive lamellar structure which restricts the potential use for sustained drug release.
32194102	5	18	theme	blending	748:755	arg1	process					757:763	the blending process	744:763	the blending process	744:763	The results of the characterization indicated that intercalation reaction happened in the blending process.
32194102	4	19	theme	Electron	637:644	arg1	Microscope					646:655	Field Emission Scanning Electron Microscope	613:655	Field Emission Scanning Electron Microscope	613:655	The resultant composite film was characterized by FT-IR, XRD and Field Emission Scanning Electron Microscope.
32194102	8	20	theme	simulated	1114:1122	arg1	mediums					1124:1130	all simulated mediums	1110:1130	all simulated mediums	1110:1130	The cumulative release rate of sample QP10-MMT0.1 was all around 20% in the first half-hour in all simulated mediums and sustained increased for more than 8 h.
32194102	6	21	theme	high	790:793	arg1	%					840:840	36.50%	835:840	36.50%	835:840	The optimum film showed high value of drug encapsulation efficiency (36.50%) and loading efficiency (80.30%).
32194102	6	21	theme	high	790:793	arg1	value					795:799	high value	790:799	high value of drug encapsulation efficiency (36.50%)	790:841	The optimum film showed high value of drug encapsulation efficiency (36.50%) and loading efficiency (80.30%).
32194102	3	22	theme	X-Ray	418:422	arg1	XRD					437:439	XRD	437:439	XRD	437:439	The Fourier transform infrared spectroscopy (FT-IR) and X-Ray diffraction (XRD) were employed to determine the variation of the functional group and crystallinity between pectin and QP.
32194102	3	22	theme	X-Ray	418:422	arg1	diffraction					424:434	X-Ray diffraction	418:434	X-Ray diffraction (XRD)	418:440	The Fourier transform infrared spectroscopy (FT-IR) and X-Ray diffraction (XRD) were employed to determine the variation of the functional group and crystallinity between pectin and QP.
32194102	7	23	theme	release	894:900	arg1	studies					902:908	The in vitro drug release studies	876:908	The in vitro drug release studies	876:908	The in vitro drug release studies revealed that the MMT significantly improved the sustained-release performance in all simulated mediums.
32194102	9	24	theme	great	1225:1229	arg1	biocompatibility					1231:1246	the great biocompatibility	1221:1246	the great biocompatibility of QP-MMT hybrid film	1221:1268	The cytotoxicity assay was performed to prove the great biocompatibility of QP-MMT hybrid film.
32194102	1	25	theme	sustained	202:210	arg1	release					217:223	sustained drug release	202:223	sustained drug release	202:223	Montmorillonite (MMT) presents nonocclusive lamellar structure which restricts the potential use for sustained drug release.
32194102	10	26	theme	release	1376:1382	arg1	performance					1384:1394	sustained drug release performance	1361:1394	sustained drug release performance	1361:1394	The present study introduced a facile route to prepare the composite film which presented sustained drug release performance.
32194102	4	27	theme	Field	613:617	arg1	Microscope					646:655	Field Emission Scanning Electron Microscope	613:655	Field Emission Scanning Electron Microscope	613:655	The resultant composite film was characterized by FT-IR, XRD and Field Emission Scanning Electron Microscope.
32194102	10	28	theme	facile	1302:1307	arg1	route					1309:1313	a facile route	1300:1313	a facile route to prepare the composite film which presented sustained drug release performance	1300:1394	The present study introduced a facile route to prepare the composite film which presented sustained drug release performance.
32194102	4	29	theme	resultant	552:560	arg1	film					572:575	The resultant composite film	548:575	The resultant composite film	548:575	The resultant composite film was characterized by FT-IR, XRD and Field Emission Scanning Electron Microscope.
32194102	0	30	theme	pectin-Montmorillonite	38:59	arg1	film					68:71	quaternized pectin-Montmorillonite hybrid film	26:71	quaternized pectin-Montmorillonite hybrid film	26:71	Design and preparation of quaternized pectin-Montmorillonite hybrid film for sustained drug release.
32194102	5	31	theme	intercalation	709:721	arg1	reaction					723:730	intercalation reaction	709:730	intercalation reaction	709:730	The results of the characterization indicated that intercalation reaction happened in the blending process.
32194102	10	32	theme	present	1275:1281	arg1	study					1283:1287	The present study	1271:1287	The present study	1271:1287	The present study introduced a facile route to prepare the composite film which presented sustained drug release performance.
32194102	4	33	theme	Scanning	628:635	arg1	Microscope					646:655	Field Emission Scanning Electron Microscope	613:655	Field Emission Scanning Electron Microscope	613:655	The resultant composite film was characterized by FT-IR, XRD and Field Emission Scanning Electron Microscope.
32194102	0	34	theme	quaternized	26:36	arg1	film					68:71	quaternized pectin-Montmorillonite hybrid film	26:71	quaternized pectin-Montmorillonite hybrid film	26:71	Design and preparation of quaternized pectin-Montmorillonite hybrid film for sustained drug release.
32194102	6	35	theme	loading	847:853	arg1	efficiency					855:864	loading efficiency	847:864	loading efficiency (80.30%)	847:873	The optimum film showed high value of drug encapsulation efficiency (36.50%) and loading efficiency (80.30%).
32194102	6	35	theme	loading	847:853	arg1	%					872:872	80.30%	867:872	80.30%	867:872	The optimum film showed high value of drug encapsulation efficiency (36.50%) and loading efficiency (80.30%).
32194102	6	36	theme	optimum	770:776	arg1	film					778:781	The optimum film	766:781	The optimum film	766:781	The optimum film showed high value of drug encapsulation efficiency (36.50%) and loading efficiency (80.30%).
32194102	4	37	theme	Emission	619:626	arg1	Microscope					646:655	Field Emission Scanning Electron Microscope	613:655	Field Emission Scanning Electron Microscope	613:655	The resultant composite film was characterized by FT-IR, XRD and Field Emission Scanning Electron Microscope.
32194102	0	38	theme	film	68:71	arg1	preparation					11:21	preparation	11:21	preparation	11:21	Design and preparation of quaternized pectin-Montmorillonite hybrid film for sustained drug release.
32194102	0	38	theme	film	68:71	arg1	Design					0:5	Design	0:5	Design	0:5	Design and preparation of quaternized pectin-Montmorillonite hybrid film for sustained drug release.
32194102	0	39	theme	hybrid	61:66	arg1	film					68:71	quaternized pectin-Montmorillonite hybrid film	26:71	quaternized pectin-Montmorillonite hybrid film	26:71	Design and preparation of quaternized pectin-Montmorillonite hybrid film for sustained drug release.
32194102	10	40	theme	drug	1371:1374	arg1	performance					1384:1394	sustained drug release performance	1361:1394	sustained drug release performance	1361:1394	The present study introduced a facile route to prepare the composite film which presented sustained drug release performance.
32194102	8	41	theme	cumulative	1019:1028	arg1	all					1069:1071	all	1069:1071	all	1069:1071	The cumulative release rate of sample QP10-MMT0.1 was all around 20% in the first half-hour in all simulated mediums and sustained increased for more than 8 h.
32194102	8	41	theme	cumulative	1019:1028	arg1	rate					1038:1041	The cumulative release rate	1015:1041	The cumulative release rate of sample QP10-MMT0.1	1015:1063	The cumulative release rate of sample QP10-MMT0.1 was all around 20% in the first half-hour in all simulated mediums and sustained increased for more than 8 h.
32194102	2	42	theme	hybrid	333:338	arg1	film					340:343	QP-MMT hybrid film	326:343	QP-MMT hybrid film containing 5-FU	326:359	To solve the limitation, the quaternized pectin (QP) was synthesized and firstly introduced to form QP-MMT hybrid film containing 5-FU.
32194102	10	43	theme	sustained	1361:1369	arg1	performance					1384:1394	sustained drug release performance	1361:1394	sustained drug release performance	1361:1394	The present study introduced a facile route to prepare the composite film which presented sustained drug release performance.
32194102	7	44	theme	simulated	996:1004	arg1	mediums					1006:1012	all simulated mediums	992:1012	all simulated mediums	992:1012	The in vitro drug release studies revealed that the MMT significantly improved the sustained-release performance in all simulated mediums.
32194102	1	45	theme	nonocclusive	132:143	arg1	structure					154:162	nonocclusive lamellar structure	132:162	nonocclusive lamellar structure which restricts the potential use for sustained drug release	132:223	Montmorillonite (MMT) presents nonocclusive lamellar structure which restricts the potential use for sustained drug release.
32194102	7	46	theme	drug	889:892	arg1	studies					902:908	The in vitro drug release studies	876:908	The in vitro drug release studies	876:908	The in vitro drug release studies revealed that the MMT significantly improved the sustained-release performance in all simulated mediums.
32194102	5	47	theme	characterization	677:692	arg1	results					662:668	The results	658:668	The results of the characterization	658:692	The results of the characterization indicated that intercalation reaction happened in the blending process.
32194102	7	48	dep	in	880:881	arg1	vitro					883:887	vitro	883:887	vitro	883:887	The in vitro drug release studies revealed that the MMT significantly improved the sustained-release performance in all simulated mediums.
32194102	1	49	theme	lamellar	145:152	arg1	structure					154:162	nonocclusive lamellar structure	132:162	nonocclusive lamellar structure which restricts the potential use for sustained drug release	132:223	Montmorillonite (MMT) presents nonocclusive lamellar structure which restricts the potential use for sustained drug release.
32194102	2	50	theme	QP-MMT	326:331	arg1	film					340:343	QP-MMT hybrid film	326:343	QP-MMT hybrid film containing 5-FU	326:359	To solve the limitation, the quaternized pectin (QP) was synthesized and firstly introduced to form QP-MMT hybrid film containing 5-FU.
32194102	0	51	theme	sustained	77:85	arg1	release					92:98	sustained drug release	77:98	sustained drug release	77:98	Design and preparation of quaternized pectin-Montmorillonite hybrid film for sustained drug release.
32194102	9	52	theme	QP-MMT	1251:1256	arg1	film					1265:1268	QP-MMT hybrid film	1251:1268	QP-MMT hybrid film	1251:1268	The cytotoxicity assay was performed to prove the great biocompatibility of QP-MMT hybrid film.
32194102	2	53	theme	quaternized	255:265	arg1	QP					275:276	QP	275:276	QP	275:276	To solve the limitation, the quaternized pectin (QP) was synthesized and firstly introduced to form QP-MMT hybrid film containing 5-FU.
32194102	2	53	theme	quaternized	255:265	arg1	pectin					267:272	the quaternized pectin	251:272	the quaternized pectin (QP)	251:277	To solve the limitation, the quaternized pectin (QP) was synthesized and firstly introduced to form QP-MMT hybrid film containing 5-FU.
32194102	1	54	theme	drug	212:215	arg1	release					217:223	sustained drug release	202:223	sustained drug release	202:223	Montmorillonite (MMT) presents nonocclusive lamellar structure which restricts the potential use for sustained drug release.
32194102	3	55	theme	group	501:505	arg1	variation					473:481	the variation	469:481	the variation of the functional group and crystallinity between pectin and QP	469:545	The Fourier transform infrared spectroscopy (FT-IR) and X-Ray diffraction (XRD) were employed to determine the variation of the functional group and crystallinity between pectin and QP.
32194102	7	56	theme	in	880:881	arg1	studies					902:908	The in vitro drug release studies	876:908	The in vitro drug release studies	876:908	The in vitro drug release studies revealed that the MMT significantly improved the sustained-release performance in all simulated mediums.
32194102	9	57	theme	hybrid	1258:1263	arg1	film					1265:1268	QP-MMT hybrid film	1251:1268	QP-MMT hybrid film	1251:1268	The cytotoxicity assay was performed to prove the great biocompatibility of QP-MMT hybrid film.
32194102	10	58	theme	composite	1330:1338	arg1	film					1340:1343	the composite film	1326:1343	the composite film which presented sustained drug release performance	1326:1394	The present study introduced a facile route to prepare the composite film which presented sustained drug release performance.
32194102	8	59	theme	first	1091:1095	arg1	half-hour					1097:1105	the first half-hour	1087:1105	the first half-hour in all simulated mediums	1087:1130	The cumulative release rate of sample QP10-MMT0.1 was all around 20% in the first half-hour in all simulated mediums and sustained increased for more than 8 h.
34074159	0	0	theme	phosphate	83:91	arg1	properties					59:68	the biomechanical and anti-collapse properties	23:68	the biomechanical and anti-collapse properties of dicalcium phosphate	23:91	Effects of pullulan on the biomechanical and anti-collapse properties of dicalcium phosphate dihydrate bone cement.
34074159	1	1	theme	monohydrate	325:335	arg1	reaction					291:298	the hydration reaction	277:298	the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse	277:618	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	5	2	theme	better	1407:1412	arg1	potential					1414:1422	better potential	1407:1422	better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement	1407:1533	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	1	3	theme	dicalcium	141:149	arg1	cement					183:188	a modified dicalcium phosphate dihydrate (DCPD) bone cement	130:188	a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system	130:259	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	4	4	theme	interface	1052:1060	arg1	bonding					1062:1068	interface bonding	1052:1068	interface bonding	1052:1068	The results indicated that Pul promoted the hydration formation of DCPD, and interface bonding occurred between Pul and DCPD.
34074159	1	5	theme	calcium	229:235	arg1	system					254:259	a calcium phosphate cement system	227:259	a calcium phosphate cement system	227:259	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	0	6	theme	dicalcium	73:81	arg1	phosphate					83:91	dicalcium phosphate	73:91	dicalcium phosphate	73:91	Effects of pullulan on the biomechanical and anti-collapse properties of dicalcium phosphate dihydrate bone cement.
34074159	3	7	theme	infrared	808:815	arg1	spectroscopy					817:828	Fourier-transform infrared spectroscopy	790:828	Fourier-transform infrared spectroscopy	790:828	The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements.
34074159	5	8	theme	bone	1468:1471	arg1	medicine					1486:1493	non-loading bone regenerative medicine	1456:1493	non-loading bone regenerative medicine	1456:1493	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	1	9	theme	biocompatible	405:417	arg1	pullulan					376:383	pullulan	376:383	pullulan (Pul)	376:389	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	9	theme	biocompatible	405:417	arg1	polysaccharide					447:460	a non-toxic, biocompatible, viscous, and water-soluble polysaccharide	392:460	a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse	392:618	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	10	theme	phosphate	151:159	arg1	cement					183:188	a modified dicalcium phosphate dihydrate (DCPD) bone cement	130:188	a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system	130:259	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	11	theme	easy	606:609	arg1	collapse					611:618	easy collapse	606:618	easy collapse	606:618	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	12	theme	phosphate	237:245	arg1	system					254:259	a calcium phosphate cement system	227:259	a calcium phosphate cement system	227:259	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	0	13	theme	bone	103:106	arg1	cement					108:113	bone cement	103:113	bone cement	103:113	Effects of pullulan on the biomechanical and anti-collapse properties of dicalcium phosphate dihydrate bone cement.
34074159	0	14	from	Effects	0:6	arg1	properties					59:68	the biomechanical and anti-collapse properties	23:68	the biomechanical and anti-collapse properties of dicalcium phosphate	23:91	Effects of pullulan on the biomechanical and anti-collapse properties of dicalcium phosphate dihydrate bone cement.
34074159	5	15	theme	regenerative	1473:1484	arg1	medicine					1486:1493	non-loading bone regenerative medicine	1456:1493	non-loading bone regenerative medicine	1456:1493	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	1	16	theme	cement	247:252	arg1	system					254:259	a calcium phosphate cement system	227:259	a calcium phosphate cement system	227:259	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	17	theme	oxide	349:353	arg1	reaction					291:298	the hydration reaction	277:298	the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse	277:618	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	5	18	theme	medicine	1486:1493	arg1	field					1447:1451	the field	1443:1451	the field of non-loading bone regenerative medicine	1443:1493	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	1	19	theme	viscous	420:426	arg1	pullulan					376:383	pullulan	376:383	pullulan (Pul)	376:389	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	19	theme	viscous	420:426	arg1	polysaccharide					447:460	a non-toxic, biocompatible, viscous, and water-soluble polysaccharide	392:460	a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse	392:618	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	20	theme	DCPD	516:519	arg1	cement					526:531	DCPD bone cement	516:531	DCPD bone cement	516:531	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	5	21	theme	interface	1333:1341	arg1	bonding					1343:1349	the strong interface bonding	1322:1349	the strong interface bonding	1322:1349	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	3	22	theme	photoelectron	899:911	arg1	analysis					926:933	X-ray photoelectron spectroscopy analysis	893:933	X-ray photoelectron spectroscopy analysis	893:933	The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements.
34074159	1	23	with	reaction	291:298	arg1	Pul					386:388	Pul	386:388	Pul	386:388	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	23	with	reaction	291:298	arg1	pullulan					376:383	pullulan	376:383	pullulan (Pul)	376:389	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	23	with	reaction	291:298	arg1	polysaccharide					447:460	a non-toxic, biocompatible, viscous, and water-soluble polysaccharide	392:460	a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse	392:618	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	24	theme	bone	521:524	arg1	cement					526:531	DCPD bone cement	516:531	DCPD bone cement	516:531	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	25	theme	dihydrate	161:169	arg1	cement					183:188	a modified dicalcium phosphate dihydrate (DCPD) bone cement	130:188	a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system	130:259	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	4	26	theme	hydration	1019:1027	arg1	formation					1029:1037	the hydration formation	1015:1037	the hydration formation of DCPD	1015:1045	The results indicated that Pul promoted the hydration formation of DCPD, and interface bonding occurred between Pul and DCPD.
34074159	3	27	theme	Fourier-transform	790:806	arg1	spectroscopy					817:828	Fourier-transform infrared spectroscopy	790:828	Fourier-transform infrared spectroscopy	790:828	The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements.
34074159	2	28	theme	Pul	657:659	arg1	contents					645:652	different contents	635:652	different contents of Pul	635:659	The effect of different contents of Pul on the structure and properties of DCPD were also studied in detail.
34074159	5	29	theme	compressive	1214:1224	arg1	strength					1226:1233	the compressive strength	1210:1233	the compressive strength	1210:1233	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	5	30	theme	strong	1326:1331	arg1	bonding					1343:1349	the strong interface bonding	1322:1349	the strong interface bonding	1322:1349	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	4	31	theme	DCPD	1042:1045	arg1	formation					1029:1037	the hydration formation	1015:1037	the hydration formation of DCPD	1015:1045	The results indicated that Pul promoted the hydration formation of DCPD, and interface bonding occurred between Pul and DCPD.
34074159	1	32	theme	water-soluble	433:445	arg1	pullulan					376:383	pullulan	376:383	pullulan (Pul)	376:389	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	32	theme	water-soluble	433:445	arg1	polysaccharide					447:460	a non-toxic, biocompatible, viscous, and water-soluble polysaccharide	392:460	a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse	392:618	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	5	33	theme	anti-collapse	1277:1289	arg1	ability					1291:1297	the anti-collapse ability	1273:1297	the anti-collapse ability	1273:1297	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	3	34	theme	X-ray	893:897	arg1	analysis					926:933	X-ray photoelectron spectroscopy analysis	893:933	X-ray photoelectron spectroscopy analysis	893:933	The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements.
34074159	1	35	theme	DCPD	172:175	arg1	cement					183:188	a modified dicalcium phosphate dihydrate (DCPD) bone cement	130:188	a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system	130:259	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	5	36	theme	bone	1162:1165	arg1	cement					1167:1172	the DCPD bone cement	1153:1172	the DCPD bone cement	1153:1172	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	5	37	theme	non-loading	1456:1466	arg1	medicine					1486:1493	non-loading bone regenerative medicine	1456:1493	non-loading bone regenerative medicine	1456:1493	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	2	38	theme	contents	645:652	arg1	effect					625:630	The effect	621:630	The effect of different contents of Pul on the structure and properties of DCPD	621:699	The effect of different contents of Pul on the structure and properties of DCPD were also studied in detail.
34074159	1	39	used	used	489:492	arg2	pullulan					376:383	pullulan	376:383	pullulan (Pul)	376:389	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	39	used	used	489:492	arg2	polysaccharide					447:460	a non-toxic, biocompatible, viscous, and water-soluble polysaccharide	392:460	a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse	392:618	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	5	40	theme	cement	1167:1172	arg1	time					1145:1148	the setting time	1133:1148	the setting time of the DCPD bone cement	1133:1172	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	5	41	theme	bone	1523:1526	arg1	cement					1528:1533	unmodified DCPD bone cement	1507:1533	unmodified DCPD bone cement	1507:1533	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	2	42	theme	different	635:643	arg1	contents					645:652	different contents	635:652	different contents of Pul	635:659	The effect of different contents of Pul on the structure and properties of DCPD were also studied in detail.
34074159	3	43	theme	rheological	940:950	arg1	measurements					961:972	rheological property measurements	940:972	rheological property measurements	940:972	The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements.
34074159	1	44	theme	bone	178:181	arg1	cement					183:188	a modified dicalcium phosphate dihydrate (DCPD) bone cement	130:188	a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system	130:259	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	0	45	theme	pullulan	11:18	arg1	Effects					0:6	Effects	0:6	Effects of pullulan on the biomechanical and anti-collapse properties of dicalcium phosphate	0:91	Effects of pullulan on the biomechanical and anti-collapse properties of dicalcium phosphate dihydrate bone cement.
34074159	5	46	contain	has	1403:1405	arg2	potential					1414:1422	better potential	1407:1422	better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement	1407:1533	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	5	46	contain	has	1403:1405	arg1	cement					1380:1385	the DCPD bone cement	1366:1385	the DCPD bone cement improved by Pul	1366:1401	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	1	47	theme	rapid	549:553	arg1	solidification					555:568	especially its rapid solidification	534:568	especially its rapid solidification	534:568	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	0	48	theme	biomechanical	27:39	arg1	properties					59:68	the biomechanical and anti-collapse properties	23:68	the biomechanical and anti-collapse properties of dicalcium phosphate	23:91	Effects of pullulan on the biomechanical and anti-collapse properties of dicalcium phosphate dihydrate bone cement.
34074159	3	49	theme	spectroscopy	913:924	arg1	analysis					926:933	X-ray photoelectron spectroscopy analysis	893:933	X-ray photoelectron spectroscopy analysis	893:933	The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements.
34074159	2	50	dep	structure	668:676	arg1	the					664:666	the	664:666	the	664:666	The effect of different contents of Pul on the structure and properties of DCPD were also studied in detail.
34074159	1	51	from	defects	505:511	arg1	cement					526:531	DCPD bone cement	516:531	DCPD bone cement	516:531	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	51	from	defects	505:511	arg1	properties					590:599	fragile mechanical properties	571:599	fragile mechanical properties	571:599	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	51	from	defects	505:511	arg1	solidification					555:568	especially its rapid solidification	534:568	especially its rapid solidification	534:568	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	51	from	defects	505:511	arg1	collapse					611:618	easy collapse	606:618	easy collapse	606:618	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	52	theme	hydration	281:289	arg1	reaction					291:298	the hydration reaction	277:298	the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse	277:618	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	53	with	cement	183:188	arg1	ability					216:222	unique biodegradable ability	195:222	unique biodegradable ability	195:222	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	54	theme	unique	195:200	arg1	ability					216:222	unique biodegradable ability	195:222	unique biodegradable ability	195:222	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	0	55	theme	anti-collapse	45:57	arg1	properties					59:68	the biomechanical and anti-collapse properties	23:68	the biomechanical and anti-collapse properties of dicalcium phosphate	23:91	Effects of pullulan on the biomechanical and anti-collapse properties of dicalcium phosphate dihydrate bone cement.
34074159	3	56	theme	modified	734:741	arg1	cement					743:748	The modified cement	730:748	The modified cement	730:748	The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements.
34074159	5	57	theme	DCPD	1370:1373	arg1	cement					1380:1385	the DCPD bone cement	1366:1385	the DCPD bone cement improved by Pul	1366:1401	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	1	58	theme	calcium	341:347	arg1	oxide					349:353	calcium oxide	341:353	calcium oxide	341:353	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	5	59	theme	Pul	1128:1130	arg1	content					1117:1123	content	1117:1123	content of Pul	1117:1130	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	3	60	theme	property	952:959	arg1	measurements					961:972	rheological property measurements	940:972	rheological property measurements	940:972	The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements.
34074159	3	61	theme	scanning	831:838	arg1	microscopy					849:858	scanning electron microscopy	831:858	scanning electron microscopy	831:858	The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements.
34074159	1	62	theme	monocalcium	303:313	arg1	monohydrate					325:335	monocalcium phosphate monohydrate	303:335	monocalcium phosphate monohydrate	303:335	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	5	63	theme	unmodified	1507:1516	arg1	cement					1528:1533	unmodified DCPD bone cement	1507:1533	unmodified DCPD bone cement	1507:1533	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	5	64	theme	bone	1375:1378	arg1	cement					1380:1385	the DCPD bone cement	1366:1385	the DCPD bone cement improved by Pul	1366:1401	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	1	65	from	cement	183:188	arg1	system					254:259	a calcium phosphate cement system	227:259	a calcium phosphate cement system	227:259	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	5	66	theme	DCPD	1157:1160	arg1	cement					1167:1172	the DCPD bone cement	1153:1172	the DCPD bone cement	1153:1172	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	1	67	theme	fragile	571:577	arg1	properties					590:599	fragile mechanical properties	571:599	fragile mechanical properties	571:599	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	68	theme	biodegradable	202:214	arg1	ability					216:222	unique biodegradable ability	195:222	unique biodegradable ability	195:222	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	5	69	theme	DCPD	1518:1521	arg1	cement					1528:1533	unmodified DCPD bone cement	1507:1533	unmodified DCPD bone cement	1507:1533	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	1	70	theme	non-toxic	394:402	arg1	pullulan					376:383	pullulan	376:383	pullulan (Pul)	376:389	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	70	theme	non-toxic	394:402	arg1	polysaccharide					447:460	a non-toxic, biocompatible, viscous, and water-soluble polysaccharide	392:460	a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse	392:618	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	2	71	from	effect	625:630	arg1	structure					668:676	structure	668:676	structure	668:676	The effect of different contents of Pul on the structure and properties of DCPD were also studied in detail.
34074159	2	71	from	effect	625:630	arg1	properties					682:691	properties	682:691	properties	682:691	The effect of different contents of Pul on the structure and properties of DCPD were also studied in detail.
34074159	1	72	theme	mechanical	579:588	arg1	properties					590:599	fragile mechanical properties	571:599	fragile mechanical properties	571:599	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	3	73	theme	X-ray	771:775	arg1	diffraction					777:787	X-ray diffraction	771:787	X-ray diffraction	771:787	The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements.
34074159	5	74	from	application	1428:1438	arg1	field					1447:1451	the field	1443:1451	the field of non-loading bone regenerative medicine	1443:1493	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	5	75	theme	setting	1137:1143	arg1	time					1145:1148	the setting time	1133:1148	the setting time of the DCPD bone cement	1133:1172	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	2	76	theme	DCPD	696:699	arg1	structure					668:676	structure	668:676	structure	668:676	The effect of different contents of Pul on the structure and properties of DCPD were also studied in detail.
34074159	2	76	theme	DCPD	696:699	arg1	properties					682:691	properties	682:691	properties	682:691	The effect of different contents of Pul on the structure and properties of DCPD were also studied in detail.
34074159	3	77	theme	electron	840:847	arg1	microscopy					849:858	scanning electron microscopy	831:858	scanning electron microscopy	831:858	The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements.
34074159	5	78	dep	20.4 MPa	1259:1266	arg1	0 MPa					1250:1254	0 MPa	1250:1254	0 MPa	1250:1254	With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
34074159	1	79	theme	phosphate	315:323	arg1	monohydrate					325:335	monocalcium phosphate monohydrate	303:335	monocalcium phosphate monohydrate	303:335	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	1	80	theme	modified	132:139	arg1	cement					183:188	a modified dicalcium phosphate dihydrate (DCPD) bone cement	130:188	a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system	130:259	In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse.
34074159	3	81	theme	ultraviolet-visible	861:879	arg1	absorption					881:890	ultraviolet-visible absorption	861:890	ultraviolet-visible absorption	861:890	The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements.
33800794	0	0	theme	Pesticides	68:77	arg1	Removal					57:63	Removal	57:63	Removal of Pesticides from Water	57:88	Poly(β-cyclodextrin)-Activated Carbon Gel Composites for Removal of Pesticides from Water.
33800794	6	1	theme	composites	866:875	arg1	preparation					802:812	preparation	802:812	preparation	802:812	In this paper, we describe the synthesis and preparation of activated carbon-containing poly(β-cyclodextrin) composites.
33800794	6	1	theme	composites	866:875	arg1	synthesis					788:796	synthesis	788:796	synthesis	788:796	In this paper, we describe the synthesis and preparation of activated carbon-containing poly(β-cyclodextrin) composites.
33800794	10	2	theme	sorbed	1333:1338	arg1	pesticide					1350:1358	pesticide	1350:1358	pesticide	1350:1358	The composites were able to release around 30% of the initial sorbed amount of pesticide without losing the capacity to keep the maximum removal efficiency in sorption/desorption cycles.
33800794	10	2	theme	sorbed	1333:1338	arg1	amount					1340:1345	the initial sorbed amount	1321:1345	the initial sorbed amount of pesticide	1321:1358	The composites were able to release around 30% of the initial sorbed amount of pesticide without losing the capacity to keep the maximum removal efficiency in sorption/desorption cycles.
33800794	10	3	theme	removal	1408:1414	arg1	efficiency					1416:1425	the maximum removal efficiency	1396:1425	the maximum removal efficiency in sorption/desorption cycles	1396:1455	The composites were able to release around 30% of the initial sorbed amount of pesticide without losing the capacity to keep the maximum removal efficiency in sorption/desorption cycles.
33800794	8	4	theme	carbon	1090:1095	arg1	carbon					1090:1095	activated carbon	1080:1095	activated carbon	1080:1095	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	8	4	theme	carbon	1090:1095	arg1	Composites					1048:1057	Composites	1048:1057	Composites with 5 and 10 wt% of activated carbon	1048:1095	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	2	5	theme	substantial	176:186	arg1	percentage					188:197	A substantial percentage	174:197	A substantial percentage of the active substances applied	174:230	A substantial percentage of the active substances applied is retained in the soil or flows into water courses, constituting a very relevant environmental problem.
33800794	4	6	theme	adsorbents	528:537	arg1	use					511:513	the use	507:513	the use of effective adsorbents in removing pesticides which are, simultaneously, capable of releasing pesticides into the soil when needed	507:645	An alternative to current methods relies on the use of effective adsorbents in removing pesticides which are, simultaneously, capable of releasing pesticides into the soil when needed.
33800794	8	7	theme	good	1109:1112	arg1	stability					1114:1122	very good stability	1104:1122	very good stability	1104:1122	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	8	8	dep	mg	1203:1204	arg1	50					1200:1201	50	1200:1201	50	1200:1201	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	8	9	dep	50	1200:1201	arg1	ca.					1196:1198	ca.	1196:1198	ca.	1196:1198	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	6	10	theme	poly	845:848	arg1	composites					866:875	activated carbon-containing poly(β-cyclodextrin) composites	817:875	activated carbon-containing poly(β-cyclodextrin) composites	817:875	In this paper, we describe the synthesis and preparation of activated carbon-containing poly(β-cyclodextrin) composites.
33800794	7	11	theme	different	915:923	arg1	cymoxanil					1020:1028	cymoxanil	1020:1028	cymoxanil	1020:1028	The composites were characterized by different techniques and their ability to absorb pesticides was assessed by using two active substances: cymoxanil and imidacloprid.
33800794	7	11	theme	different	915:923	arg1	techniques					925:934	different techniques	915:934	different techniques	915:934	The composites were characterized by different techniques and their ability to absorb pesticides was assessed by using two active substances: cymoxanil and imidacloprid.
33800794	7	11	theme	different	915:923	arg1	imidacloprid					1034:1045	imidacloprid	1034:1045	imidacloprid	1034:1045	The composites were characterized by different techniques and their ability to absorb pesticides was assessed by using two active substances: cymoxanil and imidacloprid.
33800794	8	12	with	Composites	1048:1057	arg1	%					1075:1075	5 and 10 wt%	1064:1075	5 and 10 wt%	1064:1075	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	8	13	theme	sorption	1172:1179	arg1	capacity					1181:1188	pesticide sorption capacity	1162:1188	pesticide sorption capacity	1162:1188	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	5	14	theme	waste	700:704	arg1	treatments					706:715	waste treatments	700:715	waste treatments	700:715	This reduces costs related to their application and waste treatments and, thus, overall environmental costs.
33800794	6	15	theme	carbon-containing	827:843	arg1	poly					845:848	carbon-containing poly	827:848	activated carbon-containing poly(β-cyclodextrin) composites	817:875	In this paper, we describe the synthesis and preparation of activated carbon-containing poly(β-cyclodextrin) composites.
33800794	6	15	theme	carbon-containing	827:843	arg1	β-cyclodextrin					850:863	β-cyclodextrin	850:863	β-cyclodextrin	850:863	In this paper, we describe the synthesis and preparation of activated carbon-containing poly(β-cyclodextrin) composites.
33800794	0	16	theme	Carbon	31:36	arg1	Composites					42:51	Poly(β-cyclodextrin)-Activated Carbon Gel Composites	0:51	Poly(β-cyclodextrin)-Activated Carbon Gel Composites	0:51	Poly(β-cyclodextrin)-Activated Carbon Gel Composites for Removal of Pesticides from Water.
33800794	1	17	theme	crop	157:160	arg1	production					162:171	crop production	157:171	crop production	157:171	Pesticides are widely used in agriculture to increase and protect crop production.
33800794	8	18	theme	removal	1130:1136	arg1	efficiencies					1138:1149	high removal efficiencies	1125:1149	high removal efficiencies (>75%)	1125:1156	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	8	18	theme	removal	1130:1136	arg1	%					1155:1155	>75%	1152:1155	>75%	1152:1155	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	6	19	theme	activated	817:825	arg1	composites					866:875	activated carbon-containing poly(β-cyclodextrin) composites	817:875	activated carbon-containing poly(β-cyclodextrin) composites	817:875	In this paper, we describe the synthesis and preparation of activated carbon-containing poly(β-cyclodextrin) composites.
33800794	9	20	theme	additives	1225:1233	arg1	effect					1215:1220	The effect	1211:1220	The effect of additives (NaCl and urea)	1211:1249	The effect of additives (NaCl and urea) was also evaluated.
33800794	8	21	theme	high	1125:1128	arg1	efficiencies					1138:1149	high removal efficiencies	1125:1149	high removal efficiencies (>75%)	1125:1156	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	8	21	theme	high	1125:1128	arg1	%					1155:1155	>75%	1152:1155	>75%	1152:1155	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	10	22	theme	amount	1340:1345	arg1	pesticide					1350:1358	pesticide	1350:1358	pesticide	1350:1358	The composites were able to release around 30% of the initial sorbed amount of pesticide without losing the capacity to keep the maximum removal efficiency in sorption/desorption cycles.
33800794	10	22	theme	amount	1340:1345	arg1	amount					1340:1345	the initial sorbed amount	1321:1345	the initial sorbed amount of pesticide	1321:1358	The composites were able to release around 30% of the initial sorbed amount of pesticide without losing the capacity to keep the maximum removal efficiency in sorption/desorption cycles.
33800794	10	22	theme	amount	1340:1345	arg1	%					1316:1316	30%	1314:1316	30% of the initial sorbed amount of pesticide	1314:1358	The composites were able to release around 30% of the initial sorbed amount of pesticide without losing the capacity to keep the maximum removal efficiency in sorption/desorption cycles.
33800794	1	23	used	used	113:116	arg2	Pesticides					91:100	Pesticides	91:100	Pesticides	91:100	Pesticides are widely used in agriculture to increase and protect crop production.
33800794	10	24	theme	initial	1325:1331	arg1	pesticide					1350:1358	pesticide	1350:1358	pesticide	1350:1358	The composites were able to release around 30% of the initial sorbed amount of pesticide without losing the capacity to keep the maximum removal efficiency in sorption/desorption cycles.
33800794	10	24	theme	initial	1325:1331	arg1	amount					1340:1345	the initial sorbed amount	1321:1345	the initial sorbed amount of pesticide	1321:1358	The composites were able to release around 30% of the initial sorbed amount of pesticide without losing the capacity to keep the maximum removal efficiency in sorption/desorption cycles.
33800794	3	25	theme	several	347:353	arg1	methods					355:361	several methods	347:361	several methods for the removal of pesticides from soils and water	347:412	There are several methods for the removal of pesticides from soils and water; however, their efficiency is still a challenge.
33800794	4	26	theme	effective	518:526	arg1	adsorbents					528:537	effective adsorbents	518:537	effective adsorbents	518:537	An alternative to current methods relies on the use of effective adsorbents in removing pesticides which are, simultaneously, capable of releasing pesticides into the soil when needed.
33800794	2	27	theme	water	270:274	arg1	courses					276:282	water courses	270:282	water courses	270:282	A substantial percentage of the active substances applied is retained in the soil or flows into water courses, constituting a very relevant environmental problem.
33800794	3	28	theme	pesticides	382:391	arg1	removal					371:377	the removal	367:377	the removal of pesticides from soils and water	367:412	There are several methods for the removal of pesticides from soils and water; however, their efficiency is still a challenge.
33800794	5	29	theme	related	667:673	arg1	costs					661:665	costs	661:665	costs related to their application and waste treatments	661:715	This reduces costs related to their application and waste treatments and, thus, overall environmental costs.
33800794	10	30	from	efficiency	1416:1425	arg1	cycles					1450:1455	sorption/desorption cycles	1430:1455	sorption/desorption cycles	1430:1455	The composites were able to release around 30% of the initial sorbed amount of pesticide without losing the capacity to keep the maximum removal efficiency in sorption/desorption cycles.
33800794	0	31	dep	Composites	42:51	arg1	Removal					57:63	Removal	57:63	Removal of Pesticides from Water	57:88	Poly(β-cyclodextrin)-Activated Carbon Gel Composites for Removal of Pesticides from Water.
33800794	0	32	theme	-Activated	20:29	arg1	Composites					42:51	Poly(β-cyclodextrin)-Activated Carbon Gel Composites	0:51	Poly(β-cyclodextrin)-Activated Carbon Gel Composites	0:51	Poly(β-cyclodextrin)-Activated Carbon Gel Composites for Removal of Pesticides from Water.
33800794	5	33	theme	overall	728:734	arg1	costs					750:754	overall environmental costs	728:754	overall environmental costs	728:754	This reduces costs related to their application and waste treatments and, thus, overall environmental costs.
33800794	2	34	theme	substances	213:222	arg1	percentage					188:197	A substantial percentage	174:197	A substantial percentage of the active substances applied	174:230	A substantial percentage of the active substances applied is retained in the soil or flows into water courses, constituting a very relevant environmental problem.
33800794	5	35	theme	environmental	736:748	arg1	costs					750:754	overall environmental costs	728:754	overall environmental costs	728:754	This reduces costs related to their application and waste treatments and, thus, overall environmental costs.
33800794	4	36	theme	current	481:487	arg1	methods					489:495	current methods	481:495	current methods	481:495	An alternative to current methods relies on the use of effective adsorbents in removing pesticides which are, simultaneously, capable of releasing pesticides into the soil when needed.
33800794	7	37	theme	active	1001:1006	arg1	substances					1008:1017	two active substances	997:1017	two active substances	997:1017	The composites were characterized by different techniques and their ability to absorb pesticides was assessed by using two active substances: cymoxanil and imidacloprid.
33800794	2	38	theme	active	206:211	arg1	substances					213:222	the active substances	202:222	the active substances applied	202:230	A substantial percentage of the active substances applied is retained in the soil or flows into water courses, constituting a very relevant environmental problem.
33800794	2	39	theme	environmental	314:326	arg1	problem					328:334	a very relevant environmental problem	298:334	a very relevant environmental problem	298:334	A substantial percentage of the active substances applied is retained in the soil or flows into water courses, constituting a very relevant environmental problem.
33800794	0	40	theme	Gel	38:40	arg1	Composites					42:51	Poly(β-cyclodextrin)-Activated Carbon Gel Composites	0:51	Poly(β-cyclodextrin)-Activated Carbon Gel Composites	0:51	Poly(β-cyclodextrin)-Activated Carbon Gel Composites for Removal of Pesticides from Water.
33800794	10	41	theme	maximum	1400:1406	arg1	efficiency					1416:1425	the maximum removal efficiency	1396:1425	the maximum removal efficiency in sorption/desorption cycles	1396:1455	The composites were able to release around 30% of the initial sorbed amount of pesticide without losing the capacity to keep the maximum removal efficiency in sorption/desorption cycles.
33800794	10	42	theme	pesticide	1350:1358	arg1	pesticide					1350:1358	pesticide	1350:1358	pesticide	1350:1358	The composites were able to release around 30% of the initial sorbed amount of pesticide without losing the capacity to keep the maximum removal efficiency in sorption/desorption cycles.
33800794	10	42	theme	pesticide	1350:1358	arg1	amount					1340:1345	the initial sorbed amount	1321:1345	the initial sorbed amount of pesticide	1321:1358	The composites were able to release around 30% of the initial sorbed amount of pesticide without losing the capacity to keep the maximum removal efficiency in sorption/desorption cycles.
33800794	2	43	theme	relevant	305:312	arg1	problem					328:334	a very relevant environmental problem	298:334	a very relevant environmental problem	298:334	A substantial percentage of the active substances applied is retained in the soil or flows into water courses, constituting a very relevant environmental problem.
33800794	9	44	dep	additives	1225:1233	arg1	additives					1225:1233	additives	1225:1233	additives (NaCl and urea)	1225:1249	The effect of additives (NaCl and urea) was also evaluated.
33800794	9	44	dep	additives	1225:1233	arg1	urea					1245:1248	urea	1245:1248	urea	1245:1248	The effect of additives (NaCl and urea) was also evaluated.
33800794	9	44	dep	additives	1225:1233	arg1	NaCl					1236:1239	NaCl	1236:1239	NaCl	1236:1239	The effect of additives (NaCl and urea) was also evaluated.
33800794	8	45	theme	wt	1073:1074	arg1	%					1075:1075	5 and 10 wt%	1064:1075	5 and 10 wt%	1064:1075	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	0	46	from	Water	84:88	arg1	Removal					57:63	Removal	57:63	Removal of Pesticides from Water	57:88	Poly(β-cyclodextrin)-Activated Carbon Gel Composites for Removal of Pesticides from Water.
33800794	3	47	from	soils	398:402	arg1	removal					371:377	the removal	367:377	the removal of pesticides from soils and water	367:412	There are several methods for the removal of pesticides from soils and water; however, their efficiency is still a challenge.
33800794	7	48	dep	techniques	925:934	arg1	cymoxanil					1020:1028	cymoxanil	1020:1028	cymoxanil	1020:1028	The composites were characterized by different techniques and their ability to absorb pesticides was assessed by using two active substances: cymoxanil and imidacloprid.
33800794	7	48	dep	techniques	925:934	arg1	techniques					925:934	different techniques	915:934	different techniques	915:934	The composites were characterized by different techniques and their ability to absorb pesticides was assessed by using two active substances: cymoxanil and imidacloprid.
33800794	7	48	dep	techniques	925:934	arg1	imidacloprid					1034:1045	imidacloprid	1034:1045	imidacloprid	1034:1045	The composites were characterized by different techniques and their ability to absorb pesticides was assessed by using two active substances: cymoxanil and imidacloprid.
33800794	8	49	theme	activated	1080:1088	arg1	carbon					1090:1095	activated carbon	1080:1095	activated carbon	1080:1095	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	8	50	theme	pesticide	1162:1170	arg1	capacity					1181:1188	pesticide sorption capacity	1162:1188	pesticide sorption capacity	1162:1188	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	10	51	theme	sorption/desorption	1430:1448	arg1	cycles					1450:1455	sorption/desorption cycles	1430:1455	sorption/desorption cycles	1430:1455	The composites were able to release around 30% of the initial sorbed amount of pesticide without losing the capacity to keep the maximum removal efficiency in sorption/desorption cycles.
33800794	8	52	dep	g-1	1206:1208	arg1	mg					1203:1204	mg	1203:1204	mg	1203:1204	Composites with 5 and 10 wt% of activated carbon showed very good stability, high removal efficiencies (>75%) and pesticide sorption capacity up to ca. 50 mg g-1.
33800794	3	53	from	water	408:412	arg1	removal					371:377	the removal	367:377	the removal of pesticides from soils and water	367:412	There are several methods for the removal of pesticides from soils and water; however, their efficiency is still a challenge.
33800794	2	54	dep	soil	251:254	arg1	the					247:249	the	247:249	the	247:249	A substantial percentage of the active substances applied is retained in the soil or flows into water courses, constituting a very relevant environmental problem.
33800794	6	55	dep	synthesis	788:796	arg1	the					784:786	the	784:786	the	784:786	In this paper, we describe the synthesis and preparation of activated carbon-containing poly(β-cyclodextrin) composites.
33770858	7	0	theme	SOM	1418:1420	arg1	variation					1436:1444	SOM compositional variation	1418:1444	SOM compositional variation	1418:1444	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	10	1	theme	soil	1759:1762	arg1	factors					1764:1770	soil factors	1759:1770	soil factors	1759:1770	Our results suggest that SOM composition at a local scale is closely linked with soil factors and the bacterial community.
33770858	5	2	theme	moss-derived	1035:1046	arg1	SOM					1048:1050	Sphagnum moss-derived SOM	1026:1050	Sphagnum moss-derived SOM	1026:1050	The sampling sites were grouped into three, based on their SOM compositions: Sphagnum moss-derived SOM, lipid-rich materials, and aromatic-rich materials.
33770858	11	3	theme	ecosystem	1830:1838	arg1	components					1840:1849	ecosystem components	1830:1849	ecosystem components	1830:1849	Comprehensive observation of ecosystem components is recommended to understand the in-situ function of bacteria and the fate of SOM in the moist acidic tundra.
33770858	6	4	theme	spatial	1296:1302	arg1	structuring					1304:1314	overall spatial structuring	1288:1314	overall spatial structuring	1288:1314	Our results show that SOM composition is spatially structured and linked to microtopography; however, the vegetation, soil properties, and bacterial community composition did not show overall spatial structuring.
33770858	1	5	theme	vulnerable	336:345	arg1	ecosystems					325:334	tundra ecosystems	318:334	tundra ecosystems vulnerable to climate change	318:363	Soil organic matter (SOM) is related to vegetation, soil bacteria, and soil properties; however, not many studies link all these parameters simultaneously, particularly in tundra ecosystems vulnerable to climate change.
33770858	10	6	theme	bacterial	1780:1788	arg1	community					1790:1798	the bacterial community	1776:1798	the bacterial community	1776:1798	Our results suggest that SOM composition at a local scale is closely linked with soil factors and the bacterial community.
33770858	2	7	theme	acidic	484:489	arg1	tundra					491:496	moist acidic tundra	478:496	moist acidic tundra	478:496	Our aim was to describe the relationships between vegetation, bacteria, soil properties, and SOM composition in moist acidic tundra by integrating physical, chemical, and molecular methods.
33770858	7	8	theme	bacterial	1353:1361	arg1	composition					1373:1383	bacterial community composition	1353:1383	bacterial community composition	1353:1383	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	7	8	theme	bacterial	1353:1361	arg1	properties					1338:1347	soil properties	1333:1347	soil properties	1333:1347	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	7	8	theme	bacterial	1353:1361	arg1	factors					1399:1405	the main factors	1390:1405	the main factors explaining SOM compositional variation	1390:1444	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	0	9	theme	acidic	121:126	arg1	tundra					128:133	moist acidic tundra	115:133	moist acidic tundra in Alaska	115:143	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.
33770858	1	10	theme	climate	350:356	arg1	change					358:363	climate change	350:363	climate change	350:363	Soil organic matter (SOM) is related to vegetation, soil bacteria, and soil properties; however, not many studies link all these parameters simultaneously, particularly in tundra ecosystems vulnerable to climate change.
33770858	2	11	theme	chemical	523:530	arg1	methods					547:553	physical, chemical, and molecular methods	513:553	physical, chemical, and molecular methods	513:553	Our aim was to describe the relationships between vegetation, bacteria, soil properties, and SOM composition in moist acidic tundra by integrating physical, chemical, and molecular methods.
33770858	3	12	from	spots	630:634	arg1	depths					615:620	two different depths	601:620	two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively	601:879	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	3	13	theme	Pyrolysis-gas	696:708	arg1	spectrometry					730:741	300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry	682:741	300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry	682:741	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	2	14	theme	physical	513:520	arg1	methods					547:553	physical, chemical, and molecular methods	513:553	physical, chemical, and molecular methods	513:553	Our aim was to describe the relationships between vegetation, bacteria, soil properties, and SOM composition in moist acidic tundra by integrating physical, chemical, and molecular methods.
33770858	6	15	theme	community	1253:1261	arg1	composition					1263:1273	bacterial community composition	1243:1273	bacterial community composition	1243:1273	Our results show that SOM composition is spatially structured and linked to microtopography; however, the vegetation, soil properties, and bacterial community composition did not show overall spatial structuring.
33770858	5	16	theme	SOM	1008:1010	arg1	compositions					1012:1023	their SOM compositions	1002:1023	their SOM compositions	1002:1023	The sampling sites were grouped into three, based on their SOM compositions: Sphagnum moss-derived SOM, lipid-rich materials, and aromatic-rich materials.
33770858	8	17	attach	linked	1574:1579	arg1	compounds					1593:1601	aromatic compounds	1584:1601	aromatic compounds	1584:1601	Verrucomicrobia and Acidobacteria were related to polysaccharides, and Chloroflexi was linked to aromatic compounds.
33770858	8	17	attach	linked	1574:1579	arg2	Chloroflexi					1558:1568	Chloroflexi	1558:1568	Chloroflexi	1558:1568	Verrucomicrobia and Acidobacteria were related to polysaccharides, and Chloroflexi was linked to aromatic compounds.
33770858	7	18	contain	had	1464:1466	arg2	effect					1479:1484	a residual effect	1468:1484	a residual effect	1468:1484	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	7	18	contain	had	1464:1466	arg1	vegetation					1453:1462	vegetation	1453:1462	vegetation	1453:1462	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	5	19	link	moss-derived	1035:1046	arg1	SOM					1048:1050	Sphagnum moss-derived SOM	1026:1050	Sphagnum moss-derived SOM	1026:1050	The sampling sites were grouped into three, based on their SOM compositions: Sphagnum moss-derived SOM, lipid-rich materials, and aromatic-rich materials.
33770858	2	20	theme	soil	438:441	arg1	properties					443:452	soil properties	438:452	soil properties	438:452	Our aim was to describe the relationships between vegetation, bacteria, soil properties, and SOM composition in moist acidic tundra by integrating physical, chemical, and molecular methods.
33770858	0	21	theme	properties	60:69	arg1	relationships					4:16	The relationships	0:16	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.	0:144	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.
33770858	1	22	theme	Soil	146:149	arg1	SOM					167:169	SOM	167:169	SOM	167:169	Soil organic matter (SOM) is related to vegetation, soil bacteria, and soil properties; however, not many studies link all these parameters simultaneously, particularly in tundra ecosystems vulnerable to climate change.
33770858	1	22	theme	Soil	146:149	arg1	matter					159:164	Soil organic matter	146:164	Soil organic matter (SOM)	146:170	Soil organic matter (SOM) is related to vegetation, soil bacteria, and soil properties; however, not many studies link all these parameters simultaneously, particularly in tundra ecosystems vulnerable to climate change.
33770858	4	23	theme	physicochemical	902:916	arg1	properties					918:927	Vegetation and soil physicochemical properties	882:927	Vegetation and soil physicochemical properties	882:927	Vegetation and soil physicochemical properties were also measured.
33770858	3	24	theme	rRNA	773:776	arg1	gene					778:781	the 16S rRNA gene	765:781	the 16S rRNA gene	765:781	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	0	25	theme	soil	76:79	arg1	characteristics					96:110	soil organic matter characteristics	76:110	soil organic matter characteristics in moist acidic tundra in Alaska	76:143	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.
33770858	3	26	theme	community	857:865	arg1	compositions					819:830	the molecular compositions	805:830	the molecular compositions of the SOM and bacterial community, respectively	805:879	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	2	27	theme	SOM	459:461	arg1	composition					463:473	SOM composition	459:473	SOM composition	459:473	Our aim was to describe the relationships between vegetation, bacteria, soil properties, and SOM composition in moist acidic tundra by integrating physical, chemical, and molecular methods.
33770858	11	28	from	fate	1921:1924	arg1	tundra					1953:1958	the moist acidic tundra	1936:1958	the moist acidic tundra	1936:1958	Comprehensive observation of ecosystem components is recommended to understand the in-situ function of bacteria and the fate of SOM in the moist acidic tundra.
33770858	0	29	theme	matter	89:94	arg1	characteristics					96:110	soil organic matter characteristics	76:110	soil organic matter characteristics in moist acidic tundra in Alaska	76:143	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.
33770858	1	30	theme	tundra	318:323	arg1	ecosystems					325:334	tundra ecosystems	318:334	tundra ecosystems vulnerable to climate change	318:363	Soil organic matter (SOM) is related to vegetation, soil bacteria, and soil properties; however, not many studies link all these parameters simultaneously, particularly in tundra ecosystems vulnerable to climate change.
33770858	11	31	theme	moist	1940:1944	arg1	tundra					1953:1958	the moist acidic tundra	1936:1958	the moist acidic tundra	1936:1958	Comprehensive observation of ecosystem components is recommended to understand the in-situ function of bacteria and the fate of SOM in the moist acidic tundra.
33770858	0	32	theme	vegetation	29:38	arg1	relationships					4:16	The relationships	0:16	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.	0:144	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.
33770858	1	33	theme	many	247:250	arg1	studies					252:258	not many studies	243:258	not many studies	243:258	Soil organic matter (SOM) is related to vegetation, soil bacteria, and soil properties; however, not many studies link all these parameters simultaneously, particularly in tundra ecosystems vulnerable to climate change.
33770858	3	34	theme	soil	570:573	arg1	samples					575:581	70 soil samples	567:581	70 soil samples	567:581	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	0	35	theme	bacteria	41:48	arg1	relationships					4:16	The relationships	0:16	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.	0:144	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.
33770858	8	36	theme	aromatic	1584:1591	arg1	compounds					1593:1601	aromatic compounds	1584:1601	aromatic compounds	1584:1601	Verrucomicrobia and Acidobacteria were related to polysaccharides, and Chloroflexi was linked to aromatic compounds.
33770858	3	37	theme	different	605:613	arg1	depths					615:620	two different depths	601:620	two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively	601:879	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	1	38	theme	soil	198:201	arg1	bacteria					203:210	soil bacteria	198:210	soil bacteria	198:210	Soil organic matter (SOM) is related to vegetation, soil bacteria, and soil properties; however, not many studies link all these parameters simultaneously, particularly in tundra ecosystems vulnerable to climate change.
33770858	7	39	theme	residual	1470:1477	arg1	effect					1479:1484	a residual effect	1468:1484	a residual effect	1468:1484	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	9	40	theme	hierarchical	1657:1668	arg1	levels					1670:1675	different hierarchical levels	1647:1675	different hierarchical levels	1647:1675	These relationships were consistent across different hierarchical levels.
33770858	6	41	theme	bacterial	1243:1251	arg1	composition					1263:1273	bacterial community composition	1243:1273	bacterial community composition	1243:1273	Our results show that SOM composition is spatially structured and linked to microtopography; however, the vegetation, soil properties, and bacterial community composition did not show overall spatial structuring.
33770858	11	42	theme	bacteria	1904:1911	arg1	function					1892:1899	the in-situ function	1880:1899	the in-situ function of bacteria	1880:1911	Comprehensive observation of ecosystem components is recommended to understand the in-situ function of bacteria and the fate of SOM in the moist acidic tundra.
33770858	11	42	theme	bacteria	1904:1911	arg1	fate					1921:1924	the fate	1917:1924	the fate of SOM in the moist acidic tundra	1917:1958	Comprehensive observation of ecosystem components is recommended to understand the in-situ function of bacteria and the fate of SOM in the moist acidic tundra.
33770858	2	43	theme	molecular	537:545	arg1	methods					547:553	physical, chemical, and molecular methods	513:553	physical, chemical, and molecular methods	513:553	Our aim was to describe the relationships between vegetation, bacteria, soil properties, and SOM composition in moist acidic tundra by integrating physical, chemical, and molecular methods.
33770858	1	44	theme	soil	217:220	arg1	properties					222:231	soil properties	217:231	soil properties	217:231	Soil organic matter (SOM) is related to vegetation, soil bacteria, and soil properties; however, not many studies link all these parameters simultaneously, particularly in tundra ecosystems vulnerable to climate change.
33770858	10	45	from	scale	1730:1734	arg1	composition					1707:1717	SOM composition	1703:1717	SOM composition at a local scale	1703:1734	Our results suggest that SOM composition at a local scale is closely linked with soil factors and the bacterial community.
33770858	7	46	theme	compositional	1422:1434	arg1	variation					1436:1444	SOM compositional variation	1418:1444	SOM compositional variation	1418:1444	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	6	47	theme	soil	1222:1225	arg1	properties					1227:1236	soil properties	1222:1236	soil properties	1222:1236	Our results show that SOM composition is spatially structured and linked to microtopography; however, the vegetation, soil properties, and bacterial community composition did not show overall spatial structuring.
33770858	1	48	theme	organic	151:157	arg1	SOM					167:169	SOM	167:169	SOM	167:169	Soil organic matter (SOM) is related to vegetation, soil bacteria, and soil properties; however, not many studies link all these parameters simultaneously, particularly in tundra ecosystems vulnerable to climate change.
33770858	1	48	theme	organic	151:157	arg1	matter					159:164	Soil organic matter	146:164	Soil organic matter (SOM)	146:170	Soil organic matter (SOM) is related to vegetation, soil bacteria, and soil properties; however, not many studies link all these parameters simultaneously, particularly in tundra ecosystems vulnerable to climate change.
33770858	6	49	theme	SOM	1126:1128	arg1	composition					1130:1140	SOM composition	1126:1140	SOM composition	1126:1140	Our results show that SOM composition is spatially structured and linked to microtopography; however, the vegetation, soil properties, and bacterial community composition did not show overall spatial structuring.
33770858	6	50	attach	linked	1170:1175	arg2	composition					1130:1140	SOM composition	1126:1140	SOM composition	1126:1140	Our results show that SOM composition is spatially structured and linked to microtopography; however, the vegetation, soil properties, and bacterial community composition did not show overall spatial structuring.
33770858	6	50	attach	linked	1170:1175	arg1	microtopography					1180:1194	microtopography	1180:1194	microtopography	1180:1194	Our results show that SOM composition is spatially structured and linked to microtopography; however, the vegetation, soil properties, and bacterial community composition did not show overall spatial structuring.
33770858	7	51	theme	main	1394:1397	arg1	composition					1373:1383	bacterial community composition	1353:1383	bacterial community composition	1353:1383	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	7	51	theme	main	1394:1397	arg1	properties					1338:1347	soil properties	1333:1347	soil properties	1333:1347	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	7	51	theme	main	1394:1397	arg1	factors					1399:1405	the main factors	1390:1405	the main factors explaining SOM compositional variation	1390:1444	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	3	52	theme	300 m × 50 m.	682:694	arg1	spectrometry					730:741	300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry	682:741	300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry	682:741	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	0	53	theme	moist	115:119	arg1	tundra					128:133	moist acidic tundra	115:133	moist acidic tundra in Alaska	115:143	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.
33770858	6	54	theme	overall	1288:1294	arg1	structuring					1304:1314	overall spatial structuring	1288:1314	overall spatial structuring	1288:1314	Our results show that SOM composition is spatially structured and linked to microtopography; however, the vegetation, soil properties, and bacterial community composition did not show overall spatial structuring.
33770858	5	55	theme	Sphagnum	1026:1033	arg1	SOM					1048:1050	Sphagnum moss-derived SOM	1026:1050	Sphagnum moss-derived SOM	1026:1050	The sampling sites were grouped into three, based on their SOM compositions: Sphagnum moss-derived SOM, lipid-rich materials, and aromatic-rich materials.
33770858	4	56	theme	Vegetation	882:891	arg1	properties					918:927	Vegetation and soil physicochemical properties	882:927	Vegetation and soil physicochemical properties	882:927	Vegetation and soil physicochemical properties were also measured.
33770858	7	57	theme	community	1363:1371	arg1	composition					1373:1383	bacterial community composition	1353:1383	bacterial community composition	1353:1383	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	7	57	theme	community	1363:1371	arg1	properties					1338:1347	soil properties	1333:1347	soil properties	1333:1347	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	7	57	theme	community	1363:1371	arg1	factors					1399:1405	the main factors	1390:1405	the main factors explaining SOM compositional variation	1390:1444	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	11	58	theme	components	1840:1849	arg1	observation					1815:1825	Comprehensive observation	1801:1825	Comprehensive observation of ecosystem components	1801:1849	Comprehensive observation of ecosystem components is recommended to understand the in-situ function of bacteria and the fate of SOM in the moist acidic tundra.
33770858	0	59	from	characteristics	96:110	arg1	tundra					128:133	moist acidic tundra	115:133	moist acidic tundra in Alaska	115:143	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.
33770858	3	60	theme	chromatography/mass	710:728	arg1	spectrometry					730:741	300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry	682:741	300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry	682:741	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	3	61	theme	molecular	809:817	arg1	compositions					819:830	the molecular compositions	805:830	the molecular compositions of the SOM and bacterial community, respectively	805:879	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	7	62	theme	soil	1333:1336	arg1	composition					1373:1383	bacterial community composition	1353:1383	bacterial community composition	1353:1383	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	7	62	theme	soil	1333:1336	arg1	factors					1399:1405	the main factors	1390:1405	the main factors explaining SOM compositional variation	1390:1444	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	7	62	theme	soil	1333:1336	arg1	properties					1338:1347	soil properties	1333:1347	soil properties	1333:1347	Simultaneously, soil properties and bacterial community composition were the main factors explaining SOM compositional variation, while vegetation had a residual effect.
33770858	3	63	theme	16S	769:771	arg1	gene					778:781	the 16S rRNA gene	765:781	the 16S rRNA gene	765:781	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	0	64	theme	soil	55:58	arg1	properties					60:69	soil properties	55:69	soil properties	55:69	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.
33770858	5	65	theme	aromatic-rich	1079:1091	arg1	materials					1093:1101	aromatic-rich materials	1079:1101	aromatic-rich materials	1079:1101	The sampling sites were grouped into three, based on their SOM compositions: Sphagnum moss-derived SOM, lipid-rich materials, and aromatic-rich materials.
33770858	3	66	theme	SOM	839:841	arg1	compositions					819:830	the molecular compositions	805:830	the molecular compositions of the SOM and bacterial community, respectively	805:879	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	2	67	from	relationships	394:406	arg1	tundra					491:496	moist acidic tundra	478:496	moist acidic tundra	478:496	Our aim was to describe the relationships between vegetation, bacteria, soil properties, and SOM composition in moist acidic tundra by integrating physical, chemical, and molecular methods.
33770858	11	68	theme	Comprehensive	1801:1813	arg1	observation					1815:1825	Comprehensive observation	1801:1825	Comprehensive observation of ecosystem components	1801:1849	Comprehensive observation of ecosystem components is recommended to understand the in-situ function of bacteria and the fate of SOM in the moist acidic tundra.
33770858	0	69	theme	organic	81:87	arg1	characteristics					96:110	soil organic matter characteristics	76:110	soil organic matter characteristics in moist acidic tundra in Alaska	76:143	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.
33770858	4	70	theme	soil	897:900	arg1	properties					918:927	Vegetation and soil physicochemical properties	882:927	Vegetation and soil physicochemical properties	882:927	Vegetation and soil physicochemical properties were also measured.
33770858	3	71	theme	gene	778:781	arg1	pyrosequencing					747:760	pyrosequencing	747:760	pyrosequencing of the 16S rRNA gene	747:781	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	3	71	theme	gene	778:781	arg1	spectrometry					730:741	300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry	682:741	300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry	682:741	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	5	72	theme	lipid-rich	1053:1062	arg1	materials					1064:1072	lipid-rich materials	1053:1072	lipid-rich materials	1053:1072	The sampling sites were grouped into three, based on their SOM compositions: Sphagnum moss-derived SOM, lipid-rich materials, and aromatic-rich materials.
33770858	3	73	used	used	788:791	arg2	pyrosequencing					747:760	pyrosequencing	747:760	pyrosequencing of the 16S rRNA gene	747:781	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	3	73	used	used	788:791	arg2	spectrometry					730:741	300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry	682:741	300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry	682:741	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	3	74	theme	bacterial	847:855	arg1	community					857:865	bacterial community	847:865	bacterial community	847:865	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	11	75	from	function	1892:1899	arg1	tundra					1953:1958	the moist acidic tundra	1936:1958	the moist acidic tundra	1936:1958	Comprehensive observation of ecosystem components is recommended to understand the in-situ function of bacteria and the fate of SOM in the moist acidic tundra.
33770858	11	76	theme	SOM	1929:1931	arg1	function					1892:1899	the in-situ function	1880:1899	the in-situ function of bacteria	1880:1911	Comprehensive observation of ecosystem components is recommended to understand the in-situ function of bacteria and the fate of SOM in the moist acidic tundra.
33770858	11	76	theme	SOM	1929:1931	arg1	fate					1921:1924	the fate	1917:1924	the fate of SOM in the moist acidic tundra	1917:1958	Comprehensive observation of ecosystem components is recommended to understand the in-situ function of bacteria and the fate of SOM in the moist acidic tundra.
33770858	0	77	theme	present	21:27	arg1	vegetation					29:38	present vegetation	21:38	present vegetation	21:38	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.
33770858	3	78	theme	samples	575:581	arg1	total					558:562	A total	556:562	A total of 70 soil samples	556:581	A total of 70 soil samples were collected at two different depths from 36 spots systematically arranged over an area of about 300 m × 50 m. Pyrolysis-gas chromatography/mass spectrometry and pyrosequencing of the 16S rRNA gene were used to identify the molecular compositions of the SOM and bacterial community, respectively.
33770858	10	79	theme	SOM	1703:1705	arg1	composition					1707:1717	SOM composition	1703:1717	SOM composition at a local scale	1703:1734	Our results suggest that SOM composition at a local scale is closely linked with soil factors and the bacterial community.
33770858	11	80	theme	acidic	1946:1951	arg1	tundra					1953:1958	the moist acidic tundra	1936:1958	the moist acidic tundra	1936:1958	Comprehensive observation of ecosystem components is recommended to understand the in-situ function of bacteria and the fate of SOM in the moist acidic tundra.
33770858	2	81	theme	moist	478:482	arg1	tundra					491:496	moist acidic tundra	478:496	moist acidic tundra	478:496	Our aim was to describe the relationships between vegetation, bacteria, soil properties, and SOM composition in moist acidic tundra by integrating physical, chemical, and molecular methods.
33770858	0	82	with	relationships	4:16	arg1	characteristics					96:110	soil organic matter characteristics	76:110	soil organic matter characteristics in moist acidic tundra in Alaska	76:143	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.
33770858	10	83	theme	local	1724:1728	arg1	scale					1730:1734	a local scale	1722:1734	a local scale	1722:1734	Our results suggest that SOM composition at a local scale is closely linked with soil factors and the bacterial community.
33770858	5	84	theme	sampling	953:960	arg1	sites					962:966	The sampling sites	949:966	The sampling sites	949:966	The sampling sites were grouped into three, based on their SOM compositions: Sphagnum moss-derived SOM, lipid-rich materials, and aromatic-rich materials.
33770858	0	85	from	tundra	128:133	arg1	Alaska					138:143	Alaska	138:143	Alaska	138:143	The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.
33770858	11	86	theme	in-situ	1884:1890	arg1	function					1892:1899	the in-situ function	1880:1899	the in-situ function of bacteria	1880:1911	Comprehensive observation of ecosystem components is recommended to understand the in-situ function of bacteria and the fate of SOM in the moist acidic tundra.
33770858	9	87	theme	different	1647:1655	arg1	levels					1670:1675	different hierarchical levels	1647:1675	different hierarchical levels	1647:1675	These relationships were consistent across different hierarchical levels.
32388869	4	0	theme	nanocomposite	646:658	arg1	films					660:664	the nanocomposite films	642:664	the nanocomposite films	642:664	Morphology, structure and properties of the nanocomposite films were characterized using atomic force microscopy, field emission scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and mechanical testing.
32388869	1	1	theme	nanocomposite	153:165	arg1	materials					167:175	value-added composite and nanocomposite materials	127:175	value-added composite and nanocomposite materials	127:175	BACKGROUND There is a need to help farmers and industries develop value-added composite and nanocomposite materials from agricultural residuals.
32388869	6	2	theme	extracting	1037:1046	arg1	method					1048:1053	the extracting method	1033:1053	the extracting method (Composite E)	1033:1067	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	6	2	theme	extracting	1037:1046	arg1	E					1066:1066	Composite E	1056:1066	Composite E	1056:1066	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	10	3	theme	mechanical	1663:1672	arg1	properties					1674:1683	the mechanical properties	1659:1683	the mechanical properties of the all-cellulose nanocomposite films	1659:1724	In addition, the mechanical properties of the all-cellulose nanocomposite films were significantly different when the addition of CNFs reached 3.0% by weight, as indicated by a multiple-range comparison.
32388869	10	3	theme	mechanical	1663:1672	arg1	different					1745:1753	different	1745:1753	different	1745:1753	In addition, the mechanical properties of the all-cellulose nanocomposite films were significantly different when the addition of CNFs reached 3.0% by weight, as indicated by a multiple-range comparison.
32388869	8	4	theme	cellulose	1472:1480	arg1	higher					1503:1508	higher	1503:1508	higher	1503:1508	However, in contrast to Composite A, the diffraction intensity of cellulose I in Composite E was higher than that of cellulose II.
32388869	8	4	theme	cellulose	1472:1480	arg1	intensity					1459:1467	the diffraction intensity	1443:1467	the diffraction intensity of cellulose I in Composite E	1443:1497	However, in contrast to Composite A, the diffraction intensity of cellulose I in Composite E was higher than that of cellulose II.
32388869	4	5	theme	films	660:664	arg1	Morphology					602:611	Morphology	602:611	Morphology	602:611	Morphology, structure and properties of the nanocomposite films were characterized using atomic force microscopy, field emission scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and mechanical testing.
32388869	4	5	theme	films	660:664	arg1	properties					628:637	properties	628:637	properties	628:637	Morphology, structure and properties of the nanocomposite films were characterized using atomic force microscopy, field emission scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and mechanical testing.
32388869	4	5	theme	films	660:664	arg1	structure					614:622	structure	614:622	structure	614:622	Morphology, structure and properties of the nanocomposite films were characterized using atomic force microscopy, field emission scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and mechanical testing.
32388869	2	6	theme	oxidation	258:266	arg1	method					268:273	a TEMPO oxidation method	250:273	a TEMPO oxidation method	250:273	Cellulose nanofibers (CNFs) were made using a TEMPO oxidation method and celluloses were prepared by acid-base method and extracting method, which were all from corn stalk, an agricultural residual.
32388869	10	7	from	different	1745:1753	arg1	addition					1649:1656	addition	1649:1656	addition	1649:1656	In addition, the mechanical properties of the all-cellulose nanocomposite films were significantly different when the addition of CNFs reached 3.0% by weight, as indicated by a multiple-range comparison.
32388869	4	8	theme	electron	740:747	arg1	microscopy					749:758	field emission scanning electron microscopy	716:758	field emission scanning electron microscopy	716:758	Morphology, structure and properties of the nanocomposite films were characterized using atomic force microscopy, field emission scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and mechanical testing.
32388869	6	9	theme	all-cellulose	1175:1187	arg1	films					1203:1207	the all-cellulose nanocomposite films	1171:1207	the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A)	1171:1269	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	9	10	theme	mechanical	1570:1579	arg1	properties					1581:1590	the mechanical properties	1566:1590	the mechanical properties of Composite E	1566:1605	This was another reason that the mechanical properties of Composite E were superior to those of Composite A.
32388869	9	10	theme	mechanical	1570:1579	arg1	superior					1612:1619	superior	1612:1619	superior	1612:1619	This was another reason that the mechanical properties of Composite E were superior to those of Composite A.
32388869	5	11	theme	layer	951:955	arg1	structure					957:965	layer structure	951:965	layer structure	951:965	RESULTS The all-cellulose nanocomposite films with different cellulose matrices exhibited good optical transparency and layer structure.
32388869	4	12	theme	scanning	731:738	arg1	microscopy					749:758	field emission scanning electron microscopy	716:758	field emission scanning electron microscopy	716:758	Morphology, structure and properties of the nanocomposite films were characterized using atomic force microscopy, field emission scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and mechanical testing.
32388869	8	13	from	intensity	1459:1467	arg1	E					1497:1497	Composite E	1487:1497	Composite E	1487:1497	However, in contrast to Composite A, the diffraction intensity of cellulose I in Composite E was higher than that of cellulose II.
32388869	2	14	theme	extracting	328:337	arg1	method					339:344	extracting method	328:344	extracting method	328:344	Cellulose nanofibers (CNFs) were made using a TEMPO oxidation method and celluloses were prepared by acid-base method and extracting method, which were all from corn stalk, an agricultural residual.
32388869	7	15	theme	nanocomposite	1327:1339	arg1	films					1341:1345	the all-cellulose nanocomposite films	1309:1345	the all-cellulose nanocomposite films indicated the coexistence of cellulose I and cellulose II	1309:1403	CONCLUSIONS The crystal structure of the all-cellulose nanocomposite films indicated the coexistence of cellulose I and cellulose II.
32388869	6	16	theme	thermal	1110:1116	arg1	stability					1118:1126	better thermal stability	1103:1126	better thermal stability	1103:1126	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	10	17	theme	all-cellulose	1692:1704	arg1	films					1720:1724	the all-cellulose nanocomposite films	1688:1724	the all-cellulose nanocomposite films	1688:1724	In addition, the mechanical properties of the all-cellulose nanocomposite films were significantly different when the addition of CNFs reached 3.0% by weight, as indicated by a multiple-range comparison.
32388869	7	18	theme	II	1402:1403	arg1	coexistence					1361:1371	the coexistence	1357:1371	the coexistence of cellulose I and cellulose II	1357:1403	CONCLUSIONS The crystal structure of the all-cellulose nanocomposite films indicated the coexistence of cellulose I and cellulose II.
32388869	5	19	theme	nanocomposite	857:869	arg1	films					871:875	The all-cellulose nanocomposite films	839:875	The all-cellulose nanocomposite films with different cellulose matrices	839:909	RESULTS The all-cellulose nanocomposite films with different cellulose matrices exhibited good optical transparency and layer structure.
32388869	5	20	theme	good	921:924	arg1	transparency					934:945	good optical transparency	921:945	good optical transparency	921:945	RESULTS The all-cellulose nanocomposite films with different cellulose matrices exhibited good optical transparency and layer structure.
32388869	6	21	theme	nanocomposite	1189:1201	arg1	films					1203:1207	the all-cellulose nanocomposite films	1171:1207	the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A)	1171:1269	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	6	22	theme	Composite	1056:1064	arg1	method					1048:1053	the extracting method	1033:1053	the extracting method (Composite E)	1033:1067	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	6	22	theme	Composite	1056:1064	arg1	E					1066:1066	Composite E	1056:1066	Composite E	1056:1066	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	1	23	theme	agricultural	182:193	arg1	residuals					195:203	agricultural residuals	182:203	agricultural residuals	182:203	BACKGROUND There is a need to help farmers and industries develop value-added composite and nanocomposite materials from agricultural residuals.
32388869	6	24	with	films	1203:1207	arg1	cellulose					1214:1222	cellulose	1214:1222	cellulose prepared by the acid-base method (Composite A)	1214:1269	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	9	25	theme	Composite	1595:1603	arg1	E					1605:1605	Composite E	1595:1605	Composite E	1595:1605	This was another reason that the mechanical properties of Composite E were superior to those of Composite A.
32388869	7	26	theme	all-cellulose	1313:1325	arg1	films					1341:1345	the all-cellulose nanocomposite films	1309:1345	the all-cellulose nanocomposite films indicated the coexistence of cellulose I and cellulose II	1309:1403	CONCLUSIONS The crystal structure of the all-cellulose nanocomposite films indicated the coexistence of cellulose I and cellulose II.
32388869	7	27	theme	cellulose	1376:1384	arg1	I					1386:1386	cellulose I	1376:1386	cellulose I	1376:1386	CONCLUSIONS The crystal structure of the all-cellulose nanocomposite films indicated the coexistence of cellulose I and cellulose II.
32388869	4	28	theme	atomic	691:696	arg1	microscopy					704:713	atomic force microscopy	691:713	atomic force microscopy	691:713	Morphology, structure and properties of the nanocomposite films were characterized using atomic force microscopy, field emission scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and mechanical testing.
32388869	10	29	theme	films	1720:1724	arg1	properties					1674:1683	the mechanical properties	1659:1683	the mechanical properties of the all-cellulose nanocomposite films	1659:1724	In addition, the mechanical properties of the all-cellulose nanocomposite films were significantly different when the addition of CNFs reached 3.0% by weight, as indicated by a multiple-range comparison.
32388869	10	29	theme	films	1720:1724	arg1	different					1745:1753	different	1745:1753	different	1745:1753	In addition, the mechanical properties of the all-cellulose nanocomposite films were significantly different when the addition of CNFs reached 3.0% by weight, as indicated by a multiple-range comparison.
32388869	9	30	theme	E	1605:1605	arg1	properties					1581:1590	the mechanical properties	1566:1590	the mechanical properties of Composite E	1566:1605	This was another reason that the mechanical properties of Composite E were superior to those of Composite A.
32388869	9	30	theme	E	1605:1605	arg1	superior					1612:1619	superior	1612:1619	superior	1612:1619	This was another reason that the mechanical properties of Composite E were superior to those of Composite A.
32388869	5	31	theme	different	882:890	arg1	matrices					902:909	different cellulose matrices	882:909	different cellulose matrices	882:909	RESULTS The all-cellulose nanocomposite films with different cellulose matrices exhibited good optical transparency and layer structure.
32388869	4	32	theme	X-ray	789:793	arg1	diffraction					795:805	X-ray diffraction	789:805	X-ray diffraction	789:805	Morphology, structure and properties of the nanocomposite films were characterized using atomic force microscopy, field emission scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and mechanical testing.
32388869	4	33	theme	mechanical	811:820	arg1	testing					822:828	mechanical testing	811:828	mechanical testing	811:828	Morphology, structure and properties of the nanocomposite films were characterized using atomic force microscopy, field emission scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and mechanical testing.
32388869	4	34	theme	emission	722:729	arg1	microscopy					749:758	field emission scanning electron microscopy	716:758	field emission scanning electron microscopy	716:758	Morphology, structure and properties of the nanocomposite films were characterized using atomic force microscopy, field emission scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and mechanical testing.
32388869	6	35	theme	higher	1081:1086	arg1	crystallinity					1088:1100	a higher crystallinity	1079:1100	a higher crystallinity	1079:1100	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	0	36	theme	all-cellulose	15:27	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of all-cellulose	0:27	Fabrication of all-cellulose nanocomposites from corn stalk.
32388869	8	37	theme	Composite	1487:1495	arg1	E					1497:1497	Composite E	1487:1497	Composite E	1487:1497	However, in contrast to Composite A, the diffraction intensity of cellulose I in Composite E was higher than that of cellulose II.
32388869	4	38	theme	field	716:720	arg1	microscopy					749:758	field emission scanning electron microscopy	716:758	field emission scanning electron microscopy	716:758	Morphology, structure and properties of the nanocomposite films were characterized using atomic force microscopy, field emission scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and mechanical testing.
32388869	1	39	theme	composite	139:147	arg1	materials					167:175	value-added composite and nanocomposite materials	127:175	value-added composite and nanocomposite materials	127:175	BACKGROUND There is a need to help farmers and industries develop value-added composite and nanocomposite materials from agricultural residuals.
32388869	0	40	theme	corn	49:52	arg1	stalk					54:58	corn stalk	49:58	corn stalk	49:58	Fabrication of all-cellulose nanocomposites from corn stalk.
32388869	6	41	theme	nanocomposite	986:998	arg1	films					1000:1004	The all-cellulose nanocomposite films	968:1004	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E)	968:1067	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	11	42	theme	Chemical	1868:1875	arg1	Industry					1877:1884	Chemical Industry	1868:1884	Chemical Industry	1868:1884	© 2020 Society of Chemical Industry.
32388869	10	43	theme	multiple-range	1823:1836	arg1	comparison					1838:1847	a multiple-range comparison	1821:1847	a multiple-range comparison	1821:1847	In addition, the mechanical properties of the all-cellulose nanocomposite films were significantly different when the addition of CNFs reached 3.0% by weight, as indicated by a multiple-range comparison.
32388869	7	44	theme	I	1386:1386	arg1	coexistence					1361:1371	the coexistence	1357:1371	the coexistence of cellulose I and cellulose II	1357:1403	CONCLUSIONS The crystal structure of the all-cellulose nanocomposite films indicated the coexistence of cellulose I and cellulose II.
32388869	3	45	theme	prepared	409:416	arg1	celluloses					418:427	The prepared celluloses	405:427	The prepared celluloses	405:427	The prepared celluloses were dissolved separately in dimethylacetamide/LiCl solvent and CNFs were added at 0.0%, 0.5%, 1.5% and 3.0% to form all-cellulose nanocomposites, and then cast into films.
32388869	6	46	theme	all-cellulose	972:984	arg1	films					1000:1004	The all-cellulose nanocomposite films	968:1004	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E)	968:1067	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	8	47	theme	Composite	1430:1438	arg1	A					1440:1440	Composite A	1430:1440	Composite A	1430:1440	However, in contrast to Composite A, the diffraction intensity of cellulose I in Composite E was higher than that of cellulose II.
32388869	5	48	theme	all-cellulose	843:855	arg1	films					871:875	The all-cellulose nanocomposite films	839:875	The all-cellulose nanocomposite films with different cellulose matrices	839:909	RESULTS The all-cellulose nanocomposite films with different cellulose matrices exhibited good optical transparency and layer structure.
32388869	3	49	theme	dimethylacetamide/LiCl	458:479	arg1	solvent					481:487	dimethylacetamide/LiCl solvent	458:487	dimethylacetamide/LiCl solvent	458:487	The prepared celluloses were dissolved separately in dimethylacetamide/LiCl solvent and CNFs were added at 0.0%, 0.5%, 1.5% and 3.0% to form all-cellulose nanocomposites, and then cast into films.
32388869	8	50	dep	A	1440:1440	arg1	contrast					1418:1425	contrast	1418:1425	contrast	1418:1425	However, in contrast to Composite A, the diffraction intensity of cellulose I in Composite E was higher than that of cellulose II.
32388869	5	51	theme	cellulose	892:900	arg1	matrices					902:909	different cellulose matrices	882:909	different cellulose matrices	882:909	RESULTS The all-cellulose nanocomposite films with different cellulose matrices exhibited good optical transparency and layer structure.
32388869	10	52	from	addition	1649:1656	arg1	different					1745:1753	different	1745:1753	different	1745:1753	In addition, the mechanical properties of the all-cellulose nanocomposite films were significantly different when the addition of CNFs reached 3.0% by weight, as indicated by a multiple-range comparison.
32388869	10	52	from	addition	1649:1656	arg1	properties					1674:1683	the mechanical properties	1659:1683	the mechanical properties of the all-cellulose nanocomposite films	1659:1724	In addition, the mechanical properties of the all-cellulose nanocomposite films were significantly different when the addition of CNFs reached 3.0% by weight, as indicated by a multiple-range comparison.
32388869	8	53	theme	diffraction	1447:1457	arg1	higher					1503:1508	higher	1503:1508	higher	1503:1508	However, in contrast to Composite A, the diffraction intensity of cellulose I in Composite E was higher than that of cellulose II.
32388869	8	53	theme	diffraction	1447:1457	arg1	intensity					1459:1467	the diffraction intensity	1443:1467	the diffraction intensity of cellulose I in Composite E	1443:1497	However, in contrast to Composite A, the diffraction intensity of cellulose I in Composite E was higher than that of cellulose II.
32388869	6	54	theme	mechanical	1139:1148	arg1	strength					1150:1157	higher mechanical strength	1132:1157	higher mechanical strength	1132:1157	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	5	55	theme	optical	926:932	arg1	transparency					934:945	good optical transparency	921:945	good optical transparency	921:945	RESULTS The all-cellulose nanocomposite films with different cellulose matrices exhibited good optical transparency and layer structure.
32388869	6	56	with	films	1000:1004	arg1	cellulose					1011:1019	cellulose	1011:1019	cellulose prepared by the extracting method (Composite E)	1011:1067	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	7	57	theme	crystal	1288:1294	arg1	structure					1296:1304	The crystal structure	1284:1304	The crystal structure of the all-cellulose nanocomposite films indicated the coexistence of cellulose I and cellulose II	1284:1403	CONCLUSIONS The crystal structure of the all-cellulose nanocomposite films indicated the coexistence of cellulose I and cellulose II.
32388869	3	58	theme	all-cellulose	546:558	arg1	nanocomposites					560:573	all-cellulose nanocomposites	546:573	all-cellulose nanocomposites	546:573	The prepared celluloses were dissolved separately in dimethylacetamide/LiCl solvent and CNFs were added at 0.0%, 0.5%, 1.5% and 3.0% to form all-cellulose nanocomposites, and then cast into films.
32388869	7	59	theme	cellulose	1392:1400	arg1	II					1402:1403	cellulose II	1392:1403	cellulose II	1392:1403	CONCLUSIONS The crystal structure of the all-cellulose nanocomposite films indicated the coexistence of cellulose I and cellulose II.
32388869	7	60	theme	films	1341:1345	arg1	structure					1296:1304	The crystal structure	1284:1304	The crystal structure of the all-cellulose nanocomposite films indicated the coexistence of cellulose I and cellulose II	1284:1403	CONCLUSIONS The crystal structure of the all-cellulose nanocomposite films indicated the coexistence of cellulose I and cellulose II.
32388869	6	61	theme	acid-base	1240:1248	arg1	method					1250:1255	the acid-base method	1236:1255	the acid-base method (Composite A)	1236:1269	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	6	61	theme	acid-base	1240:1248	arg1	A					1268:1268	Composite A	1258:1268	Composite A	1258:1268	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	6	62	theme	Composite	1258:1266	arg1	method					1250:1255	the acid-base method	1236:1255	the acid-base method (Composite A)	1236:1269	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	6	62	theme	Composite	1258:1266	arg1	A					1268:1268	Composite A	1258:1268	Composite A	1258:1268	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	1	63	dep	BACKGROUND	61:70	arg1	is					78:79	is	78:79	is a need to help farmers and industries develop value-added composite and nanocomposite materials from agricultural residuals	78:203	BACKGROUND There is a need to help farmers and industries develop value-added composite and nanocomposite materials from agricultural residuals.
32388869	2	64	theme	acid-base	307:315	arg1	method					317:322	acid-base method	307:322	acid-base method	307:322	Cellulose nanofibers (CNFs) were made using a TEMPO oxidation method and celluloses were prepared by acid-base method and extracting method, which were all from corn stalk, an agricultural residual.
32388869	5	65	with	films	871:875	arg1	matrices					902:909	different cellulose matrices	882:909	different cellulose matrices	882:909	RESULTS The all-cellulose nanocomposite films with different cellulose matrices exhibited good optical transparency and layer structure.
32388869	4	66	theme	thermogravimetric	761:777	arg1	analysis					779:786	thermogravimetric analysis	761:786	thermogravimetric analysis	761:786	Morphology, structure and properties of the nanocomposite films were characterized using atomic force microscopy, field emission scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and mechanical testing.
32388869	1	67	theme	value-added	127:137	arg1	materials					167:175	value-added composite and nanocomposite materials	127:175	value-added composite and nanocomposite materials	127:175	BACKGROUND There is a need to help farmers and industries develop value-added composite and nanocomposite materials from agricultural residuals.
32388869	4	68	theme	force	698:702	arg1	microscopy					704:713	atomic force microscopy	691:713	atomic force microscopy	691:713	Morphology, structure and properties of the nanocomposite films were characterized using atomic force microscopy, field emission scanning electron microscopy, thermogravimetric analysis, X-ray diffraction and mechanical testing.
32388869	2	69	theme	Cellulose	206:214	arg1	nanofibers					216:225	Cellulose nanofibers	206:225	Cellulose nanofibers (CNFs)	206:232	Cellulose nanofibers (CNFs) were made using a TEMPO oxidation method and celluloses were prepared by acid-base method and extracting method, which were all from corn stalk, an agricultural residual.
32388869	2	69	theme	Cellulose	206:214	arg1	CNFs					228:231	CNFs	228:231	CNFs	228:231	Cellulose nanofibers (CNFs) were made using a TEMPO oxidation method and celluloses were prepared by acid-base method and extracting method, which were all from corn stalk, an agricultural residual.
32388869	2	70	theme	TEMPO	252:256	arg1	method					268:273	a TEMPO oxidation method	250:273	a TEMPO oxidation method	250:273	Cellulose nanofibers (CNFs) were made using a TEMPO oxidation method and celluloses were prepared by acid-base method and extracting method, which were all from corn stalk, an agricultural residual.
32388869	10	71	theme	nanocomposite	1706:1718	arg1	films					1720:1724	the all-cellulose nanocomposite films	1688:1724	the all-cellulose nanocomposite films	1688:1724	In addition, the mechanical properties of the all-cellulose nanocomposite films were significantly different when the addition of CNFs reached 3.0% by weight, as indicated by a multiple-range comparison.
32388869	2	72	theme	corn	367:370	arg1	stalk					372:376	corn stalk	367:376	corn stalk	367:376	Cellulose nanofibers (CNFs) were made using a TEMPO oxidation method and celluloses were prepared by acid-base method and extracting method, which were all from corn stalk, an agricultural residual.
32388869	6	73	theme	better	1103:1108	arg1	stability					1118:1126	better thermal stability	1103:1126	better thermal stability	1103:1126	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	10	74	theme	CNFs	1776:1779	arg1	addition					1764:1771	the addition	1760:1771	the addition of CNFs	1760:1779	In addition, the mechanical properties of the all-cellulose nanocomposite films were significantly different when the addition of CNFs reached 3.0% by weight, as indicated by a multiple-range comparison.
32388869	5	75	dep	RESULTS	831:837	arg1	exhibited					911:919	exhibited	911:919	exhibited good optical transparency and layer structure	911:965	RESULTS The all-cellulose nanocomposite films with different cellulose matrices exhibited good optical transparency and layer structure.
32388869	6	76	theme	higher	1132:1137	arg1	strength					1150:1157	higher mechanical strength	1132:1157	higher mechanical strength	1132:1157	The all-cellulose nanocomposite films with cellulose prepared by the extracting method (Composite E) exhibited a higher crystallinity, better thermal stability and higher mechanical strength compared to the all-cellulose nanocomposite films with cellulose prepared by the acid-base method (Composite A).
32388869	9	77	theme	Composite	1633:1641	arg1	A					1643:1643	Composite A	1633:1643	Composite A	1633:1643	This was another reason that the mechanical properties of Composite E were superior to those of Composite A.
32100266	6	0	theme	HA	989:990	arg1	200 mg/mL					996:1004	200 mg/mL	996:1004	200 mg/mL	996:1004	It had been found that when the concentration of HA was 200 mg/mL and the mass ratio of HA to CMS-Na was 2:1, the prepared HA composite microneedles had good mechanical strength.
32100266	6	0	theme	HA	989:990	arg1	concentration					972:984	the concentration	968:984	the concentration of HA	968:990	It had been found that when the concentration of HA was 200 mg/mL and the mass ratio of HA to CMS-Na was 2:1, the prepared HA composite microneedles had good mechanical strength.
32100266	10	1	dep	abstract	1580:1587	arg1	Graphical					1570:1578	Graphical	1570:1578	Graphical	1570:1578	Graphical abstract.
32100266	4	2	used	used	723:726	arg2	method					712:717	the dialysis method	699:717	the dialysis method	699:717	Subsequently, the dialysis method was used to prepare Cur-loaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV.
32100266	1	3	theme	acid	237:240	arg1	microneedles					257:268	novel hyaluronic acid (HA) composite microneedles	220:268	novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles	220:299	In order to improve the bioavailability of curcumin (Cur) and patient compliance, a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles was designed in this paper.
32100266	1	4	theme	curcumin	171:178	arg1	bioavailability					152:166	the bioavailability	148:166	the bioavailability of curcumin (Cur) and patient compliance	148:207	In order to improve the bioavailability of curcumin (Cur) and patient compliance, a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles was designed in this paper.
32100266	7	5	theme	HA	1179:1180	arg1	microneedles					1192:1203	the micelle-loaded HA composite microneedles	1160:1203	the micelle-loaded HA composite microneedles	1160:1203	In-skin dissolution kinetics showed that the micelle-loaded HA composite microneedles could dissolve quickly in the skin.
32100266	8	6	theme	drug	1324:1327	arg1	load					1329:1332	their drug load	1318:1332	their drug load	1318:1332	In vitro permeation study indicated that the microneedles delivered 74.7% of their drug load over 6 h, which exhibited remarkable drug permeation properties in a short time.
32100266	6	7	theme	mechanical	1098:1107	arg1	strength					1109:1116	good mechanical strength	1093:1116	good mechanical strength	1093:1116	It had been found that when the concentration of HA was 200 mg/mL and the mass ratio of HA to CMS-Na was 2:1, the prepared HA composite microneedles had good mechanical strength.
32100266	6	8	contain	had	1089:1091	arg1	microneedles					1076:1087	the prepared HA composite microneedles	1050:1087	the prepared HA composite microneedles	1050:1087	It had been found that when the concentration of HA was 200 mg/mL and the mass ratio of HA to CMS-Na was 2:1, the prepared HA composite microneedles had good mechanical strength.
32100266	6	8	contain	had	1089:1091	arg2	strength					1109:1116	good mechanical strength	1093:1116	good mechanical strength	1093:1116	It had been found that when the concentration of HA was 200 mg/mL and the mass ratio of HA to CMS-Na was 2:1, the prepared HA composite microneedles had good mechanical strength.
32100266	1	9	contain	containing	270:279	arg1	microneedles					257:268	novel hyaluronic acid (HA) composite microneedles	220:268	novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles	220:299	In order to improve the bioavailability of curcumin (Cur) and patient compliance, a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles was designed in this paper.
32100266	1	9	contain	containing	270:279	arg2	micelles					292:299	Cur-loaded micelles	281:299	Cur-loaded micelles	281:299	In order to improve the bioavailability of curcumin (Cur) and patient compliance, a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles was designed in this paper.
32100266	4	10	with	micelles	761:768	arg1	size					786:789	an average size	775:789	an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV	775:848	Subsequently, the dialysis method was used to prepare Cur-loaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV.
32100266	2	11	theme	carboxymethyl	479:491	arg1	CMS-Na					501:506	CMS-Na	501:506	CMS-Na	501:506	On the one hand, the microneedles matrix solution was prepared by screening the optimal concentration of HA and the better proportion of HA to sodium carboxymethyl starch (CMS-Na).
32100266	2	11	theme	carboxymethyl	479:491	arg1	starch					493:498	sodium carboxymethyl starch	472:498	sodium carboxymethyl starch (CMS-Na)	472:507	On the one hand, the microneedles matrix solution was prepared by screening the optimal concentration of HA and the better proportion of HA to sodium carboxymethyl starch (CMS-Na).
32100266	8	12	theme	permeation	1376:1385	arg1	properties					1387:1396	remarkable drug permeation properties	1360:1396	remarkable drug permeation properties	1360:1396	In vitro permeation study indicated that the microneedles delivered 74.7% of their drug load over 6 h, which exhibited remarkable drug permeation properties in a short time.
32100266	4	13	theme	potential	819:827	arg1	size					786:789	an average size	775:789	an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV	775:848	Subsequently, the dialysis method was used to prepare Cur-loaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV.
32100266	8	14	theme	In	1241:1242	arg1	study					1261:1265	In vitro permeation study	1241:1265	In vitro permeation study	1241:1265	In vitro permeation study indicated that the microneedles delivered 74.7% of their drug load over 6 h, which exhibited remarkable drug permeation properties in a short time.
32100266	4	15	theme	Que-DA-oHA	750:759	arg1	micelles					761:768	Cur-loaded Que-DA-oHA micelles	739:768	Cur-loaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV	739:848	Subsequently, the dialysis method was used to prepare Cur-loaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV.
32100266	5	16	theme	micromolding	853:864	arg1	process					866:872	A micromolding process	851:872	A micromolding process	851:872	A micromolding process was used to prepare the micelle-loaded HA composite microneedles.
32100266	0	17	theme	curcumin	118:125	arg1	delivery					106:113	delivery	106:113	delivery of curcumin	106:125	Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin.
32100266	2	18	theme	better	445:450	arg1	proportion					452:461	the better proportion	441:461	the better proportion of HA	441:467	On the one hand, the microneedles matrix solution was prepared by screening the optimal concentration of HA and the better proportion of HA to sodium carboxymethyl starch (CMS-Na).
32100266	4	19	theme	Cur-loaded	739:748	arg1	micelles					761:768	Cur-loaded Que-DA-oHA micelles	739:768	Cur-loaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV	739:848	Subsequently, the dialysis method was used to prepare Cur-loaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV.
32100266	2	20	theme	matrix	363:368	arg1	solution					370:377	the microneedles matrix solution	346:377	the microneedles matrix solution	346:377	On the one hand, the microneedles matrix solution was prepared by screening the optimal concentration of HA and the better proportion of HA to sodium carboxymethyl starch (CMS-Na).
32100266	9	21	dep	diseases	1533:1540	arg1	treatment					1542:1550	treatment	1542:1550	diseases treatment such as melanoma	1533:1567	Here, we creatively combined micellar technology with microneedle technology to rapidly deliver Cur transdermally for diseases treatment such as melanoma.
32100266	4	22	theme	- 33.71 ± 0.45 mV	832:848	arg1	172.6 ± 11.4 nm					794:808	172.6 ± 11.4 nm	794:808	172.6 ± 11.4 nm	794:808	Subsequently, the dialysis method was used to prepare Cur-loaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV.
32100266	4	22	theme	- 33.71 ± 0.45 mV	832:848	arg1	potential					819:827	zeta potential	814:827	zeta potential	814:827	Subsequently, the dialysis method was used to prepare Cur-loaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV.
32100266	2	23	theme	microneedles	350:361	arg1	solution					370:377	the microneedles matrix solution	346:377	the microneedles matrix solution	346:377	On the one hand, the microneedles matrix solution was prepared by screening the optimal concentration of HA and the better proportion of HA to sodium carboxymethyl starch (CMS-Na).
32100266	1	24	theme	composite	247:255	arg1	microneedles					257:268	novel hyaluronic acid (HA) composite microneedles	220:268	novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles	220:299	In order to improve the bioavailability of curcumin (Cur) and patient compliance, a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles was designed in this paper.
32100266	4	25	theme	dialysis	703:710	arg1	method					712:717	the dialysis method	699:717	the dialysis method	699:717	Subsequently, the dialysis method was used to prepare Cur-loaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV.
32100266	0	26	theme	acid	58:61	arg1	composite					63:71	dissolving hyaluronic acid composite	36:71	dissolving hyaluronic acid composite	36:71	Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin.
32100266	2	27	theme	optimal	409:415	arg1	concentration					417:429	the optimal concentration	405:429	the optimal concentration of HA	405:435	On the one hand, the microneedles matrix solution was prepared by screening the optimal concentration of HA and the better proportion of HA to sodium carboxymethyl starch (CMS-Na).
32100266	1	28	theme	microneedles	257:268	arg1	type					212:215	a type	210:215	a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles	210:299	In order to improve the bioavailability of curcumin (Cur) and patient compliance, a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles was designed in this paper.
32100266	4	29	theme	172.6 ± 11.4 nm	794:808	arg1	size					786:789	an average size	775:789	an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV	775:848	Subsequently, the dialysis method was used to prepare Cur-loaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV.
32100266	8	30	dep	In	1241:1242	arg1	vitro					1244:1248	vitro	1244:1248	vitro	1244:1248	In vitro permeation study indicated that the microneedles delivered 74.7% of their drug load over 6 h, which exhibited remarkable drug permeation properties in a short time.
32100266	1	31	theme	patient	190:196	arg1	compliance					198:207	patient compliance	190:207	patient compliance	190:207	In order to improve the bioavailability of curcumin (Cur) and patient compliance, a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles was designed in this paper.
32100266	6	32	theme	composite	1066:1074	arg1	microneedles					1076:1087	the prepared HA composite microneedles	1050:1087	the prepared HA composite microneedles	1050:1087	It had been found that when the concentration of HA was 200 mg/mL and the mass ratio of HA to CMS-Na was 2:1, the prepared HA composite microneedles had good mechanical strength.
32100266	3	33	theme	other	517:521	arg1	hand					523:526	the other hand	513:526	the other hand	513:526	On the other hand, the amphiphilic polymer, named as Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid (Que-DA-oHA), was synthesized and characterized using 1H-NMR.
32100266	1	34	theme	compliance	198:207	arg1	bioavailability					152:166	the bioavailability	148:166	the bioavailability of curcumin (Cur) and patient compliance	148:207	In order to improve the bioavailability of curcumin (Cur) and patient compliance, a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles was designed in this paper.
32100266	0	35	theme	hyaluronic	47:56	arg1	acid					58:61	dissolving hyaluronic acid	36:61	dissolving hyaluronic acid composite	36:71	Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin.
32100266	1	36	theme	Cur-loaded	281:290	arg1	micelles					292:299	Cur-loaded micelles	281:299	Cur-loaded micelles	281:299	In order to improve the bioavailability of curcumin (Cur) and patient compliance, a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles was designed in this paper.
32100266	9	37	theme	microneedle	1469:1479	arg1	technology					1481:1490	microneedle technology	1469:1490	microneedle technology	1469:1490	Here, we creatively combined micellar technology with microneedle technology to rapidly deliver Cur transdermally for diseases treatment such as melanoma.
32100266	8	38	theme	drug	1371:1374	arg1	properties					1387:1396	remarkable drug permeation properties	1360:1396	remarkable drug permeation properties	1360:1396	In vitro permeation study indicated that the microneedles delivered 74.7% of their drug load over 6 h, which exhibited remarkable drug permeation properties in a short time.
32100266	9	39	theme	micellar	1444:1451	arg1	technology					1453:1462	micellar technology	1444:1462	micellar technology	1444:1462	Here, we creatively combined micellar technology with microneedle technology to rapidly deliver Cur transdermally for diseases treatment such as melanoma.
32100266	0	40	theme	dissolving	36:45	arg1	acid					58:61	dissolving hyaluronic acid	36:61	dissolving hyaluronic acid composite	36:71	Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin.
32100266	7	41	theme	In-skin	1119:1125	arg1	kinetics					1139:1146	In-skin dissolution kinetics	1119:1146	In-skin dissolution kinetics	1119:1146	In-skin dissolution kinetics showed that the micelle-loaded HA composite microneedles could dissolve quickly in the skin.
32100266	3	42	theme	Hyaluronic	607:616	arg1	Que-DA-oHA					624:633	Que-DA-oHA	624:633	Que-DA-oHA	624:633	On the other hand, the amphiphilic polymer, named as Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid (Que-DA-oHA), was synthesized and characterized using 1H-NMR.
32100266	3	42	theme	Hyaluronic	607:616	arg1	Acid					618:621	Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid	563:621	Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid (Que-DA-oHA)	563:634	On the other hand, the amphiphilic polymer, named as Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid (Que-DA-oHA), was synthesized and characterized using 1H-NMR.
32100266	7	43	theme	dissolution	1127:1137	arg1	kinetics					1139:1146	In-skin dissolution kinetics	1119:1146	In-skin dissolution kinetics	1119:1146	In-skin dissolution kinetics showed that the micelle-loaded HA composite microneedles could dissolve quickly in the skin.
32100266	2	44	theme	sodium	472:477	arg1	CMS-Na					501:506	CMS-Na	501:506	CMS-Na	501:506	On the one hand, the microneedles matrix solution was prepared by screening the optimal concentration of HA and the better proportion of HA to sodium carboxymethyl starch (CMS-Na).
32100266	2	44	theme	sodium	472:477	arg1	starch					493:498	sodium carboxymethyl starch	472:498	sodium carboxymethyl starch (CMS-Na)	472:507	On the one hand, the microneedles matrix solution was prepared by screening the optimal concentration of HA and the better proportion of HA to sodium carboxymethyl starch (CMS-Na).
32100266	0	45	theme	composite	63:71	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin.
32100266	0	45	theme	composite	63:71	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin.
32100266	5	46	used	used	878:881	arg2	process					866:872	A micromolding process	851:872	A micromolding process	851:872	A micromolding process was used to prepare the micelle-loaded HA composite microneedles.
32100266	6	47	theme	good	1093:1096	arg1	strength					1109:1116	good mechanical strength	1093:1116	good mechanical strength	1093:1116	It had been found that when the concentration of HA was 200 mg/mL and the mass ratio of HA to CMS-Na was 2:1, the prepared HA composite microneedles had good mechanical strength.
32100266	2	48	theme	HA	434:435	arg1	concentration					417:429	the optimal concentration	405:429	the optimal concentration of HA	405:435	On the one hand, the microneedles matrix solution was prepared by screening the optimal concentration of HA and the better proportion of HA to sodium carboxymethyl starch (CMS-Na).
32100266	2	48	theme	HA	434:435	arg1	proportion					452:461	the better proportion	441:461	the better proportion of HA	441:467	On the one hand, the microneedles matrix solution was prepared by screening the optimal concentration of HA and the better proportion of HA to sodium carboxymethyl starch (CMS-Na).
32100266	4	49	theme	zeta	814:817	arg1	potential					819:827	zeta potential	814:827	zeta potential	814:827	Subsequently, the dialysis method was used to prepare Cur-loaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV.
32100266	7	50	theme	micelle-loaded	1164:1177	arg1	microneedles					1192:1203	the micelle-loaded HA composite microneedles	1160:1203	the micelle-loaded HA composite microneedles	1160:1203	In-skin dissolution kinetics showed that the micelle-loaded HA composite microneedles could dissolve quickly in the skin.
32100266	3	51	theme	amphiphilic	533:543	arg1	polymer					545:551	the amphiphilic polymer	529:551	the amphiphilic polymer	529:551	On the other hand, the amphiphilic polymer, named as Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid (Que-DA-oHA), was synthesized and characterized using 1H-NMR.
32100266	7	52	theme	composite	1182:1190	arg1	microneedles					1192:1203	the micelle-loaded HA composite microneedles	1160:1203	the micelle-loaded HA composite microneedles	1160:1203	In-skin dissolution kinetics showed that the micelle-loaded HA composite microneedles could dissolve quickly in the skin.
32100266	5	53	theme	micelle-loaded	898:911	arg1	microneedles					926:937	the micelle-loaded HA composite microneedles	894:937	the micelle-loaded HA composite microneedles	894:937	A micromolding process was used to prepare the micelle-loaded HA composite microneedles.
32100266	3	54	theme	Quercetin-Dithiodipropionic	563:589	arg1	Que-DA-oHA					624:633	Que-DA-oHA	624:633	Que-DA-oHA	624:633	On the other hand, the amphiphilic polymer, named as Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid (Que-DA-oHA), was synthesized and characterized using 1H-NMR.
32100266	3	54	theme	Quercetin-Dithiodipropionic	563:589	arg1	Acid					618:621	Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid	563:621	Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid (Que-DA-oHA)	563:634	On the other hand, the amphiphilic polymer, named as Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid (Que-DA-oHA), was synthesized and characterized using 1H-NMR.
32100266	8	55	theme	remarkable	1360:1369	arg1	properties					1387:1396	remarkable drug permeation properties	1360:1396	remarkable drug permeation properties	1360:1396	In vitro permeation study indicated that the microneedles delivered 74.7% of their drug load over 6 h, which exhibited remarkable drug permeation properties in a short time.
32100266	5	56	theme	HA	913:914	arg1	microneedles					926:937	the micelle-loaded HA composite microneedles	894:937	the micelle-loaded HA composite microneedles	894:937	A micromolding process was used to prepare the micelle-loaded HA composite microneedles.
32100266	8	57	theme	permeation	1250:1259	arg1	study					1261:1265	In vitro permeation study	1241:1265	In vitro permeation study	1241:1265	In vitro permeation study indicated that the microneedles delivered 74.7% of their drug load over 6 h, which exhibited remarkable drug permeation properties in a short time.
32100266	8	58	theme	load	1329:1332	arg1	load					1329:1332	their drug load	1318:1332	their drug load	1318:1332	In vitro permeation study indicated that the microneedles delivered 74.7% of their drug load over 6 h, which exhibited remarkable drug permeation properties in a short time.
32100266	8	58	theme	load	1329:1332	arg1	%					1313:1313	74.7%	1309:1313	74.7% of their drug load	1309:1332	In vitro permeation study indicated that the microneedles delivered 74.7% of their drug load over 6 h, which exhibited remarkable drug permeation properties in a short time.
32100266	3	59	theme	Acid-Oligomeric	591:605	arg1	Que-DA-oHA					624:633	Que-DA-oHA	624:633	Que-DA-oHA	624:633	On the other hand, the amphiphilic polymer, named as Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid (Que-DA-oHA), was synthesized and characterized using 1H-NMR.
32100266	3	59	theme	Acid-Oligomeric	591:605	arg1	Acid					618:621	Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid	563:621	Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid (Que-DA-oHA)	563:634	On the other hand, the amphiphilic polymer, named as Quercetin-Dithiodipropionic Acid-Oligomeric Hyaluronic Acid (Que-DA-oHA), was synthesized and characterized using 1H-NMR.
32100266	5	60	theme	composite	916:924	arg1	microneedles					926:937	the micelle-loaded HA composite microneedles	894:937	the micelle-loaded HA composite microneedles	894:937	A micromolding process was used to prepare the micelle-loaded HA composite microneedles.
32100266	0	61	theme	loaded	86:91	arg1	micelles					93:100	loaded micelles	86:100	loaded micelles for delivery of curcumin	86:125	Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin.
32100266	6	62	theme	mass	1014:1017	arg1	ratio					1019:1023	the mass ratio	1010:1023	the mass ratio of HA to CMS-Na	1010:1039	It had been found that when the concentration of HA was 200 mg/mL and the mass ratio of HA to CMS-Na was 2:1, the prepared HA composite microneedles had good mechanical strength.
32100266	4	63	theme	average	778:784	arg1	size					786:789	an average size	775:789	an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV	775:848	Subsequently, the dialysis method was used to prepare Cur-loaded Que-DA-oHA micelles with an average size of 172.6 ± 11.4 nm and zeta potential of - 33.71 ± 0.45 mV.
32100266	6	64	theme	HA	1028:1029	arg1	ratio					1019:1023	the mass ratio	1010:1023	the mass ratio of HA to CMS-Na	1010:1039	It had been found that when the concentration of HA was 200 mg/mL and the mass ratio of HA to CMS-Na was 2:1, the prepared HA composite microneedles had good mechanical strength.
32100266	6	65	theme	HA	1063:1064	arg1	microneedles					1076:1087	the prepared HA composite microneedles	1050:1087	the prepared HA composite microneedles	1050:1087	It had been found that when the concentration of HA was 200 mg/mL and the mass ratio of HA to CMS-Na was 2:1, the prepared HA composite microneedles had good mechanical strength.
32100266	1	66	theme	novel	220:224	arg1	microneedles					257:268	novel hyaluronic acid (HA) composite microneedles	220:268	novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles	220:299	In order to improve the bioavailability of curcumin (Cur) and patient compliance, a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles was designed in this paper.
32100266	2	67	theme	HA	466:467	arg1	concentration					417:429	the optimal concentration	405:429	the optimal concentration of HA	405:435	On the one hand, the microneedles matrix solution was prepared by screening the optimal concentration of HA and the better proportion of HA to sodium carboxymethyl starch (CMS-Na).
32100266	2	67	theme	HA	466:467	arg1	proportion					452:461	the better proportion	441:461	the better proportion of HA	441:467	On the one hand, the microneedles matrix solution was prepared by screening the optimal concentration of HA and the better proportion of HA to sodium carboxymethyl starch (CMS-Na).
32100266	8	68	theme	short	1403:1407	arg1	time					1409:1412	a short time	1401:1412	a short time	1401:1412	In vitro permeation study indicated that the microneedles delivered 74.7% of their drug load over 6 h, which exhibited remarkable drug permeation properties in a short time.
32100266	6	69	theme	prepared	1054:1061	arg1	microneedles					1076:1087	the prepared HA composite microneedles	1050:1087	the prepared HA composite microneedles	1050:1087	It had been found that when the concentration of HA was 200 mg/mL and the mass ratio of HA to CMS-Na was 2:1, the prepared HA composite microneedles had good mechanical strength.
32100266	1	70	theme	hyaluronic	226:235	arg1	HA					243:244	HA	243:244	HA	243:244	In order to improve the bioavailability of curcumin (Cur) and patient compliance, a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles was designed in this paper.
32100266	1	70	theme	hyaluronic	226:235	arg1	acid					237:240	hyaluronic acid	226:240	novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles	220:299	In order to improve the bioavailability of curcumin (Cur) and patient compliance, a type of novel hyaluronic acid (HA) composite microneedles containing Cur-loaded micelles was designed in this paper.
33142579	0	0	theme	high-yield	90:99	arg1	nanofibers					111:120	high-yield cellulose nanofibers	90:120	high-yield cellulose nanofibers	90:120	Esterification of cellulose using carboxylic acid-based deep eutectic solvents to produce high-yield cellulose nanofibers.
33142579	4	1	theme	important	709:717	arg1	roles					719:723	important roles	709:723	important roles	709:723	The DES pretreatment temperature played important roles in the esterification modifications and nanofibrillation of cellulose.
33142579	6	2	used	used	1064:1067	arg2	reinforcement					1074:1086	a reinforcement	1072:1086	a reinforcement	1072:1086	Moreover, the esterified CNFs were used as a reinforcement to prepare CNF-strengthened polylactic acid (PLA) composites.
33142579	6	2	used	used	1064:1067	arg2	CNFs					1054:1057	the esterified CNFs	1039:1057	the esterified CNFs	1039:1057	Moreover, the esterified CNFs were used as a reinforcement to prepare CNF-strengthened polylactic acid (PLA) composites.
33142579	7	3	theme	CNF/PLA	1307:1313	arg1	composites					1315:1324	CNF/PLA composites	1307:1324	CNF/PLA composites	1307:1324	The surface esterification of the CNFs improved their dispersibility and interfacial compatibility with PLA, thereby achieving the mechanical enhancement of CNF/PLA composites.
33142579	5	4	theme	I	1008:1008	arg1	structure					1018:1026	the cellulose I crystal structure	994:1026	the cellulose I crystal structure	994:1026	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	1	5	theme	emerging	157:164	arg1	solvents					172:179	emerging green solvents	157:179	emerging green solvents	157:179	Deep eutectic solvents (DESs), as emerging green solvents, provide a new opportunity for the biorefinement of biomass, component extraction, and cellulose nanofibrillation.
33142579	1	6	theme	component	242:250	arg1	extraction					252:261	component extraction	242:261	component extraction	242:261	Deep eutectic solvents (DESs), as emerging green solvents, provide a new opportunity for the biorefinement of biomass, component extraction, and cellulose nanofibrillation.
33142579	7	7	theme	surface	1154:1160	arg1	esterification					1162:1175	The surface esterification	1150:1175	The surface esterification of the CNFs	1150:1187	The surface esterification of the CNFs improved their dispersibility and interfacial compatibility with PLA, thereby achieving the mechanical enhancement of CNF/PLA composites.
33142579	3	8	theme	DESs	536:539	arg1	pretreatment					520:531	pretreatment	520:531	pretreatment of DESs combined with mechanical treatment	520:574	The results showed that pretreatment of DESs combined with mechanical treatment can swell and esterify the cellulose materials, producing CNFs with widths less than 100 nm.
33142579	5	9	theme	crystal	1010:1016	arg1	structure					1018:1026	the cellulose I crystal structure	994:1026	the cellulose I crystal structure	994:1026	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	4	10	theme	DES	673:675	arg1	temperature					690:700	The DES pretreatment temperature	669:700	The DES pretreatment temperature	669:700	The DES pretreatment temperature played important roles in the esterification modifications and nanofibrillation of cellulose.
33142579	1	11	theme	extraction	252:261	arg1	biorefinement					216:228	the biorefinement	212:228	the biorefinement of biomass, component extraction, and cellulose nanofibrillation	212:293	Deep eutectic solvents (DESs), as emerging green solvents, provide a new opportunity for the biorefinement of biomass, component extraction, and cellulose nanofibrillation.
33142579	0	12	theme	cellulose	101:109	arg1	nanofibers					111:120	high-yield cellulose nanofibers	90:120	high-yield cellulose nanofibers	90:120	Esterification of cellulose using carboxylic acid-based deep eutectic solvents to produce high-yield cellulose nanofibers.
33142579	7	13	theme	composites	1315:1324	arg1	enhancement					1292:1302	the mechanical enhancement	1277:1302	the mechanical enhancement of CNF/PLA composites	1277:1324	The surface esterification of the CNFs improved their dispersibility and interfacial compatibility with PLA, thereby achieving the mechanical enhancement of CNF/PLA composites.
33142579	4	14	theme	esterification	732:745	arg1	modifications					747:759	the esterification modifications	728:759	the esterification modifications	728:759	The DES pretreatment temperature played important roles in the esterification modifications and nanofibrillation of cellulose.
33142579	2	15	theme	raw	416:418	arg1	materials					420:428	cellulose raw materials	406:428	cellulose raw materials accompanied by simultaneous esterification modifications of CNFs	406:493	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	1	16	theme	green	166:170	arg1	solvents					172:179	emerging green solvents	157:179	emerging green solvents	157:179	Deep eutectic solvents (DESs), as emerging green solvents, provide a new opportunity for the biorefinement of biomass, component extraction, and cellulose nanofibrillation.
33142579	7	17	theme	CNFs	1184:1187	arg1	esterification					1162:1175	The surface esterification	1150:1175	The surface esterification of the CNFs	1150:1187	The surface esterification of the CNFs improved their dispersibility and interfacial compatibility with PLA, thereby achieving the mechanical enhancement of CNF/PLA composites.
33142579	5	18	theme	72	968:969	arg1	%					971:971	%	971:971	%	971:971	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	5	19	theme	cellulose	832:840	arg1	modifications					815:827	The esterification modifications	796:827	The esterification modifications of cellulose	796:840	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	3	20	theme	mechanical	555:564	arg1	treatment					566:574	mechanical treatment	555:574	mechanical treatment	555:574	The results showed that pretreatment of DESs combined with mechanical treatment can swell and esterify the cellulose materials, producing CNFs with widths less than 100 nm.
33142579	2	21	theme	esterification	458:471	arg1	modifications					473:485	simultaneous esterification modifications	445:485	simultaneous esterification modifications of CNFs	445:493	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	7	22	theme	mechanical	1281:1290	arg1	enhancement					1292:1302	the mechanical enhancement	1277:1302	the mechanical enhancement of CNF/PLA composites	1277:1324	The surface esterification of the CNFs improved their dispersibility and interfacial compatibility with PLA, thereby achieving the mechanical enhancement of CNF/PLA composites.
33142579	2	23	theme	carboxylic	314:323	arg1	DESs					336:339	different carboxylic acid-based DESs	304:339	different carboxylic acid-based DESs	304:339	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	6	24	theme	acid	1127:1130	arg1	composites					1138:1147	CNF-strengthened polylactic acid (PLA) composites	1099:1147	CNF-strengthened polylactic acid (PLA) composites	1099:1147	Moreover, the esterified CNFs were used as a reinforcement to prepare CNF-strengthened polylactic acid (PLA) composites.
33142579	2	25	theme	simultaneous	445:456	arg1	modifications					473:485	simultaneous esterification modifications	445:485	simultaneous esterification modifications of CNFs	445:493	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	5	26	dep	prevented	842:850	arg1	guaranteeing					930:941	guaranteeing	930:941	guaranteeing CNFs with high yields of 72 %-88 %	930:976	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	5	26	dep	prevented	842:850	arg1	maintaining					982:992	maintaining	982:992	maintaining the cellulose I crystal structure	982:1026	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	2	27	theme	different	304:312	arg1	DESs					336:339	different carboxylic acid-based DESs	304:339	different carboxylic acid-based DESs	304:339	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	2	28	theme	nanofibers	383:392	arg1	preparation					358:368	preparation	358:368	preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs	358:493	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	1	29	theme	cellulose	268:276	arg1	nanofibrillation					278:293	cellulose nanofibrillation	268:293	cellulose nanofibrillation	268:293	Deep eutectic solvents (DESs), as emerging green solvents, provide a new opportunity for the biorefinement of biomass, component extraction, and cellulose nanofibrillation.
33142579	5	30	theme	cellulose	998:1006	arg1	structure					1018:1026	the cellulose I crystal structure	994:1026	the cellulose I crystal structure	994:1026	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	6	31	theme	CNF-strengthened	1099:1114	arg1	acid					1127:1130	CNF-strengthened polylactic acid	1099:1130	CNF-strengthened polylactic acid (PLA) composites	1099:1147	Moreover, the esterified CNFs were used as a reinforcement to prepare CNF-strengthened polylactic acid (PLA) composites.
33142579	6	31	theme	CNF-strengthened	1099:1114	arg1	PLA					1133:1135	PLA	1133:1135	PLA	1133:1135	Moreover, the esterified CNFs were used as a reinforcement to prepare CNF-strengthened polylactic acid (PLA) composites.
33142579	0	32	theme	cellulose	18:26	arg1	Esterification					0:13	Esterification	0:13	Esterification of cellulose	0:26	Esterification of cellulose using carboxylic acid-based deep eutectic solvents to produce high-yield cellulose nanofibers.
33142579	1	33	theme	nanofibrillation	278:293	arg1	biorefinement					216:228	the biorefinement	212:228	the biorefinement of biomass, component extraction, and cellulose nanofibrillation	212:293	Deep eutectic solvents (DESs), as emerging green solvents, provide a new opportunity for the biorefinement of biomass, component extraction, and cellulose nanofibrillation.
33142579	1	34	theme	Deep	123:126	arg1	DESs					147:150	DESs	147:150	DESs	147:150	Deep eutectic solvents (DESs), as emerging green solvents, provide a new opportunity for the biorefinement of biomass, component extraction, and cellulose nanofibrillation.
33142579	1	34	theme	Deep	123:126	arg1	solvents					137:144	Deep eutectic solvents	123:144	Deep eutectic solvents (DESs)	123:151	Deep eutectic solvents (DESs), as emerging green solvents, provide a new opportunity for the biorefinement of biomass, component extraction, and cellulose nanofibrillation.
33142579	1	35	theme	new	192:194	arg1	opportunity					196:206	a new opportunity	190:206	a new opportunity for the biorefinement of biomass, component extraction, and cellulose nanofibrillation	190:293	Deep eutectic solvents (DESs), as emerging green solvents, provide a new opportunity for the biorefinement of biomass, component extraction, and cellulose nanofibrillation.
33142579	0	36	theme	acid-based	45:54	arg1	solvents					70:77	carboxylic acid-based deep eutectic solvents	34:77	carboxylic acid-based deep eutectic solvents	34:77	Esterification of cellulose using carboxylic acid-based deep eutectic solvents to produce high-yield cellulose nanofibers.
33142579	5	37	theme	DES	912:914	arg1	pretreatment					916:927	the DES pretreatment	908:927	the DES pretreatment	908:927	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	4	38	theme	pretreatment	677:688	arg1	temperature					690:700	The DES pretreatment temperature	669:700	The DES pretreatment temperature	669:700	The DES pretreatment temperature played important roles in the esterification modifications and nanofibrillation of cellulose.
33142579	2	39	theme	cellulose	406:414	arg1	materials					420:428	cellulose raw materials	406:428	cellulose raw materials accompanied by simultaneous esterification modifications of CNFs	406:493	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	0	40	theme	carboxylic	34:43	arg1	solvents					70:77	carboxylic acid-based deep eutectic solvents	34:77	carboxylic acid-based deep eutectic solvents	34:77	Esterification of cellulose using carboxylic acid-based deep eutectic solvents to produce high-yield cellulose nanofibers.
33142579	2	41	mod	modifications	473:485	arg1	CNFs					490:493	CNFs	490:493	CNFs	490:493	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	2	41	mod	modifications	473:485	arg3	esterification					458:471	simultaneous esterification modifications	445:485	simultaneous esterification modifications of CNFs	445:493	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	2	42	theme	CNFs	490:493	arg1	modifications					473:485	simultaneous esterification modifications	445:485	simultaneous esterification modifications of CNFs	445:493	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	6	43	theme	esterified	1043:1052	arg1	reinforcement					1074:1086	a reinforcement	1072:1086	a reinforcement	1072:1086	Moreover, the esterified CNFs were used as a reinforcement to prepare CNF-strengthened polylactic acid (PLA) composites.
33142579	6	43	theme	esterified	1043:1052	arg1	CNFs					1054:1057	the esterified CNFs	1039:1057	the esterified CNFs	1039:1057	Moreover, the esterified CNFs were used as a reinforcement to prepare CNF-strengthened polylactic acid (PLA) composites.
33142579	0	44	theme	eutectic	61:68	arg1	solvents					70:77	carboxylic acid-based deep eutectic solvents	34:77	carboxylic acid-based deep eutectic solvents	34:77	Esterification of cellulose using carboxylic acid-based deep eutectic solvents to produce high-yield cellulose nanofibers.
33142579	5	45	theme	high	953:956	arg1	yields					958:963	high yields	953:963	high yields of 72 %-88 %	953:976	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	5	46	with	CNFs	943:946	arg1	yields					958:963	high yields	953:963	high yields of 72 %-88 %	953:976	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	5	47	theme	esterification	800:813	arg1	modifications					815:827	The esterification modifications	796:827	The esterification modifications of cellulose	796:840	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	3	48	theme	cellulose	603:611	arg1	materials					613:621	the cellulose materials	599:621	the cellulose materials	599:621	The results showed that pretreatment of DESs combined with mechanical treatment can swell and esterify the cellulose materials, producing CNFs with widths less than 100 nm.
33142579	1	49	theme	eutectic	128:135	arg1	DESs					147:150	DESs	147:150	DESs	147:150	Deep eutectic solvents (DESs), as emerging green solvents, provide a new opportunity for the biorefinement of biomass, component extraction, and cellulose nanofibrillation.
33142579	1	49	theme	eutectic	128:135	arg1	solvents					137:144	Deep eutectic solvents	123:144	Deep eutectic solvents (DESs)	123:151	Deep eutectic solvents (DESs), as emerging green solvents, provide a new opportunity for the biorefinement of biomass, component extraction, and cellulose nanofibrillation.
33142579	0	50	theme	deep	56:59	arg1	solvents					70:77	carboxylic acid-based deep eutectic solvents	34:77	carboxylic acid-based deep eutectic solvents	34:77	Esterification of cellulose using carboxylic acid-based deep eutectic solvents to produce high-yield cellulose nanofibers.
33142579	6	51	theme	polylactic	1116:1125	arg1	acid					1127:1130	CNF-strengthened polylactic acid	1099:1130	CNF-strengthened polylactic acid (PLA) composites	1099:1147	Moreover, the esterified CNFs were used as a reinforcement to prepare CNF-strengthened polylactic acid (PLA) composites.
33142579	6	51	theme	polylactic	1116:1125	arg1	PLA					1133:1135	PLA	1133:1135	PLA	1133:1135	Moreover, the esterified CNFs were used as a reinforcement to prepare CNF-strengthened polylactic acid (PLA) composites.
33142579	5	52	dep	over-hydrolysis	856:870	arg1	the					852:854	the	852:854	the	852:854	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	5	53	theme	-88	972:974	arg1	%					971:971	%	971:971	%	971:971	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	5	54	theme	%	976:976	arg1	yields					958:963	high yields	953:963	high yields of 72 %-88 %	953:976	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	3	55	theme	less	651:654	arg1	widths					644:649	widths	644:649	widths less than 100 nm	644:666	The results showed that pretreatment of DESs combined with mechanical treatment can swell and esterify the cellulose materials, producing CNFs with widths less than 100 nm.
33142579	4	56	theme	cellulose	785:793	arg1	nanofibrillation					765:780	nanofibrillation	765:780	nanofibrillation of cellulose	765:793	The DES pretreatment temperature played important roles in the esterification modifications and nanofibrillation of cellulose.
33142579	4	56	theme	cellulose	785:793	arg1	modifications					747:759	the esterification modifications	728:759	the esterification modifications	728:759	The DES pretreatment temperature played important roles in the esterification modifications and nanofibrillation of cellulose.
33142579	2	57	theme	acid-based	325:334	arg1	DESs					336:339	different carboxylic acid-based DESs	304:339	different carboxylic acid-based DESs	304:339	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	3	58	with	CNFs	634:637	arg1	widths					644:649	widths	644:649	widths less than 100 nm	644:666	The results showed that pretreatment of DESs combined with mechanical treatment can swell and esterify the cellulose materials, producing CNFs with widths less than 100 nm.
33142579	2	59	theme	cellulose	373:381	arg1	CNFs					395:398	CNFs	395:398	CNFs	395:398	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	2	59	theme	cellulose	373:381	arg1	nanofibers					383:392	cellulose nanofibers	373:392	cellulose nanofibers (CNFs)	373:399	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	5	60	mod	modifications	815:827	arg1	cellulose					832:840	cellulose	832:840	cellulose	832:840	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	5	60	mod	modifications	815:827	arg3	esterification					800:813	The esterification modifications	796:827	The esterification modifications of cellulose	796:840	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	5	61	theme	cellulose	891:899	arg1	dissolution					876:886	dissolution	876:886	dissolution	876:886	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	5	61	theme	cellulose	891:899	arg1	over-hydrolysis					856:870	over-hydrolysis	856:870	over-hydrolysis	856:870	The esterification modifications of cellulose prevented the over-hydrolysis and dissolution of cellulose during the DES pretreatment, guaranteeing CNFs with high yields of 72 %-88 % and maintaining the cellulose I crystal structure.
33142579	2	62	from	materials	420:428	arg1	preparation					358:368	preparation	358:368	preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs	358:493	Herein, different carboxylic acid-based DESs were applied for preparation of cellulose nanofibers (CNFs) from cellulose raw materials accompanied by simultaneous esterification modifications of CNFs.
33142579	7	63	theme	interfacial	1223:1233	arg1	compatibility					1235:1247	interfacial compatibility	1223:1247	interfacial compatibility	1223:1247	The surface esterification of the CNFs improved their dispersibility and interfacial compatibility with PLA, thereby achieving the mechanical enhancement of CNF/PLA composites.
33142579	4	64	mod	modifications	747:759	arg1	cellulose					785:793	cellulose	785:793	cellulose	785:793	The DES pretreatment temperature played important roles in the esterification modifications and nanofibrillation of cellulose.
33142579	4	64	mod	modifications	747:759	arg3	esterification					732:745	the esterification modifications	728:759	the esterification modifications	728:759	The DES pretreatment temperature played important roles in the esterification modifications and nanofibrillation of cellulose.
33142579	1	65	theme	biomass	233:239	arg1	biorefinement					216:228	the biorefinement	212:228	the biorefinement of biomass, component extraction, and cellulose nanofibrillation	212:293	Deep eutectic solvents (DESs), as emerging green solvents, provide a new opportunity for the biorefinement of biomass, component extraction, and cellulose nanofibrillation.
34492826	7	0	theme	excellent	1219:1227	arg1	properties					1243:1252	excellent antibacterial properties	1219:1252	excellent antibacterial properties	1219:1252	Furthermore, the ZIF-L/SC membrane has excellent antibacterial properties, thus it is expected to deal with membrane fouling caused by microorganism breeding.
34492826	2	1	theme	self-crosslinking	365:381	arg1	membrane					393:400	ZIF-L coated self-crosslinking cellulose membrane	352:400	ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption	352:445	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	2	1	theme	self-crosslinking	365:381	arg1	membrane					412:419	ZIF-L/SC membrane	403:419	ZIF-L/SC membrane	403:419	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	8	2	theme	antibacterial	1400:1412	arg1	activity					1414:1421	excellent antibacterial activity	1390:1421	excellent antibacterial activity	1390:1421	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	4	3	theme	strong	713:718	arg1	bonding					729:735	strong hydrogen bonding	713:735	strong hydrogen bonding among cellulose fibers	713:758	The SC membrane formed by strong hydrogen bonding among cellulose fibers is an excellent substrate, due to the favorable mechanical strength and abundant hydroxyl groups.
34492826	0	4	theme	Facile	0:5	arg1	fabrication					7:17	Facile fabrication	0:17	Facile fabrication of bifunctional ZIF-L/cellulose composite membrane for efficient removal of tellurium and antibacterial effects.	0:130	Facile fabrication of bifunctional ZIF-L/cellulose composite membrane for efficient removal of tellurium and antibacterial effects.
34492826	5	5	theme	surface	939:945	arg1	morphology					911:920	advantageous morphology	898:920	advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength	898:1002	The as-prepared ZIF-L/SC membrane shows advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength.
34492826	2	6	theme	cost-effective	317:330	arg1	strategy					332:339	a facile and cost-effective strategy	304:339	a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption	304:445	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	5	7	theme	fine	948:951	arg1	stability					961:969	fine thermal stability	948:969	fine thermal stability	948:969	The as-prepared ZIF-L/SC membrane shows advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength.
34492826	6	8	theme	ZIF-L/SC	1058:1065	arg1	membrane					1067:1074	ZIF-L/SC membrane	1058:1074	ZIF-L/SC membrane	1058:1074	The adsorption performance and possible mechanism of ZIF-L/SC membrane for Te (IV) were investigated by diverse characterization methods, showing admirable adsorption effect.
34492826	8	9	theme	ZIF-L/SC	1367:1374	arg1	membrane					1376:1383	the bifunctional ZIF-L/SC membrane	1350:1383	the bifunctional ZIF-L/SC membrane with excellent antibacterial activity	1350:1421	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	8	9	theme	ZIF-L/SC	1367:1374	arg1	candidate					1456:1464	a promising candidate	1444:1464	a promising candidate for efficient tellurium adsorbents	1444:1499	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	8	10	theme	tellurium	1480:1488	arg1	adsorbents					1490:1499	efficient tellurium adsorbents	1470:1499	efficient tellurium adsorbents	1470:1499	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	2	11	theme	facile	306:311	arg1	strategy					332:339	a facile and cost-effective strategy	304:339	a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption	304:445	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	8	12	from	fields	1547:1552	arg1	future					1561:1566	future	1561:1566	future	1561:1566	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	7	13	with	deal	1278:1281	arg1	fouling					1297:1303	membrane fouling	1288:1303	membrane fouling caused by microorganism breeding	1288:1336	Furthermore, the ZIF-L/SC membrane has excellent antibacterial properties, thus it is expected to deal with membrane fouling caused by microorganism breeding.
34492826	3	14	theme	In-situ	462:468	arg1	strategy					571:578	an available strategy	558:578	an available strategy	558:578	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	3	14	theme	In-situ	462:468	arg1	growth					479:484	In-situ vertical growth	462:484	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate	462:553	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	1	15	from	removal	227:233	arg1	treatment					262:270	wastewater treatment	251:270	wastewater treatment	251:270	Fabrication of simple and efficient adsorbents is greatly vital to satisfy the requirements of removal of tellurium in wastewater treatment, yet remains challenging.
34492826	5	16	theme	large	925:929	arg1	surface					939:945	large contact surface	925:945	large contact surface	925:945	The as-prepared ZIF-L/SC membrane shows advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength.
34492826	4	17	theme	excellent	766:774	arg1	membrane					694:701	The SC membrane	687:701	The SC membrane formed by strong hydrogen bonding among cellulose fibers	687:758	The SC membrane formed by strong hydrogen bonding among cellulose fibers is an excellent substrate, due to the favorable mechanical strength and abundant hydroxyl groups.
34492826	4	17	theme	excellent	766:774	arg1	substrate					776:784	an excellent substrate	763:784	an excellent substrate	763:784	The SC membrane formed by strong hydrogen bonding among cellulose fibers is an excellent substrate, due to the favorable mechanical strength and abundant hydroxyl groups.
34492826	1	18	from	treatment	262:270	arg1	removal					227:233	removal	227:233	removal of tellurium in wastewater treatment	227:270	Fabrication of simple and efficient adsorbents is greatly vital to satisfy the requirements of removal of tellurium in wastewater treatment, yet remains challenging.
34492826	5	19	theme	strength	995:1002	arg1	morphology					911:920	advantageous morphology	898:920	advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength	898:1002	The as-prepared ZIF-L/SC membrane shows advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength.
34492826	6	20	theme	adsorption	1009:1018	arg1	performance					1020:1030	adsorption performance	1009:1030	adsorption performance	1009:1030	The adsorption performance and possible mechanism of ZIF-L/SC membrane for Te (IV) were investigated by diverse characterization methods, showing admirable adsorption effect.
34492826	2	21	dep	strategy	332:339	arg1	develop					344:350	develop	344:350	to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption	341:445	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	3	22	with	growth	479:484	arg1	properties					522:531	functional properties	511:531	functional properties on membrane substrate	511:553	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	4	23	theme	cellulose	743:751	arg1	fibers					753:758	cellulose fibers	743:758	cellulose fibers	743:758	The SC membrane formed by strong hydrogen bonding among cellulose fibers is an excellent substrate, due to the favorable mechanical strength and abundant hydroxyl groups.
34492826	0	24	theme	efficient	74:82	arg1	removal					84:90	efficient removal	74:90	efficient removal of tellurium and antibacterial effects	74:129	Facile fabrication of bifunctional ZIF-L/cellulose composite membrane for efficient removal of tellurium and antibacterial effects.
34492826	3	25	theme	unhandy	669:675	arg1	recovery					677:684	unhandy recovery	669:684	unhandy recovery	669:684	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	5	26	theme	stability	961:969	arg1	morphology					911:920	advantageous morphology	898:920	advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength	898:1002	The as-prepared ZIF-L/SC membrane shows advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength.
34492826	5	27	theme	eligible	975:982	arg1	strength					995:1002	eligible mechanical strength	975:1002	eligible mechanical strength	975:1002	The as-prepared ZIF-L/SC membrane shows advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength.
34492826	7	28	contain	has	1215:1217	arg1	membrane					1206:1213	the ZIF-L/SC membrane	1193:1213	the ZIF-L/SC membrane	1193:1213	Furthermore, the ZIF-L/SC membrane has excellent antibacterial properties, thus it is expected to deal with membrane fouling caused by microorganism breeding.
34492826	7	28	contain	has	1215:1217	arg2	properties					1243:1252	excellent antibacterial properties	1219:1252	excellent antibacterial properties	1219:1252	Furthermore, the ZIF-L/SC membrane has excellent antibacterial properties, thus it is expected to deal with membrane fouling caused by microorganism breeding.
34492826	4	29	theme	abundant	832:839	arg1	groups					850:855	abundant hydroxyl groups	832:855	abundant hydroxyl groups	832:855	The SC membrane formed by strong hydrogen bonding among cellulose fibers is an excellent substrate, due to the favorable mechanical strength and abundant hydroxyl groups.
34492826	3	30	theme	vertical	470:477	arg1	strategy					571:578	an available strategy	558:578	an available strategy	558:578	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	3	30	theme	vertical	470:477	arg1	growth					479:484	In-situ vertical growth	462:484	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate	462:553	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	0	31	theme	effects	123:129	arg1	removal					84:90	efficient removal	74:90	efficient removal of tellurium and antibacterial effects	74:129	Facile fabrication of bifunctional ZIF-L/cellulose composite membrane for efficient removal of tellurium and antibacterial effects.
34492826	6	32	theme	adsorption	1161:1170	arg1	effect					1172:1177	admirable adsorption effect	1151:1177	admirable adsorption effect	1151:1177	The adsorption performance and possible mechanism of ZIF-L/SC membrane for Te (IV) were investigated by diverse characterization methods, showing admirable adsorption effect.
34492826	5	33	theme	ZIF-L/SC	874:881	arg1	membrane					883:890	The as-prepared ZIF-L/SC membrane	858:890	The as-prepared ZIF-L/SC membrane	858:890	The as-prepared ZIF-L/SC membrane shows advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength.
34492826	4	34	theme	favorable	798:806	arg1	strength					819:826	the favorable mechanical strength	794:826	the favorable mechanical strength	794:826	The SC membrane formed by strong hydrogen bonding among cellulose fibers is an excellent substrate, due to the favorable mechanical strength and abundant hydroxyl groups.
34492826	3	35	theme	nanoplates	495:504	arg1	strategy					571:578	an available strategy	558:578	an available strategy	558:578	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	3	35	theme	nanoplates	495:504	arg1	growth					479:484	In-situ vertical growth	462:484	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate	462:553	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	1	36	theme	efficient	158:166	arg1	adsorbents					168:177	simple and efficient adsorbents	147:177	simple and efficient adsorbents	147:177	Fabrication of simple and efficient adsorbents is greatly vital to satisfy the requirements of removal of tellurium in wastewater treatment, yet remains challenging.
34492826	0	37	theme	ZIF-L/cellulose	35:49	arg1	membrane					61:68	bifunctional ZIF-L/cellulose composite membrane	22:68	bifunctional ZIF-L/cellulose composite membrane	22:68	Facile fabrication of bifunctional ZIF-L/cellulose composite membrane for efficient removal of tellurium and antibacterial effects.
34492826	6	38	theme	diverse	1109:1115	arg1	methods					1134:1140	diverse characterization methods	1109:1140	diverse characterization methods	1109:1140	The adsorption performance and possible mechanism of ZIF-L/SC membrane for Te (IV) were investigated by diverse characterization methods, showing admirable adsorption effect.
34492826	2	39	theme	coated	358:363	arg1	membrane					393:400	ZIF-L coated self-crosslinking cellulose membrane	352:400	ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption	352:445	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	2	39	theme	coated	358:363	arg1	membrane					412:419	ZIF-L/SC membrane	403:419	ZIF-L/SC membrane	403:419	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	0	40	theme	membrane	61:68	arg1	fabrication					7:17	Facile fabrication	0:17	Facile fabrication of bifunctional ZIF-L/cellulose composite membrane for efficient removal of tellurium and antibacterial effects.	0:130	Facile fabrication of bifunctional ZIF-L/cellulose composite membrane for efficient removal of tellurium and antibacterial effects.
34492826	3	41	theme	functional	511:520	arg1	properties					522:531	functional properties	511:531	functional properties on membrane substrate	511:553	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	1	42	theme	tellurium	238:246	arg1	removal					227:233	removal	227:233	removal of tellurium in wastewater treatment	227:270	Fabrication of simple and efficient adsorbents is greatly vital to satisfy the requirements of removal of tellurium in wastewater treatment, yet remains challenging.
34492826	1	43	theme	adsorbents	168:177	arg1	Fabrication					132:142	Fabrication	132:142	Fabrication of simple and efficient adsorbents	132:177	Fabrication of simple and efficient adsorbents is greatly vital to satisfy the requirements of removal of tellurium in wastewater treatment, yet remains challenging.
34492826	3	44	theme	ZIF-L	489:493	arg1	nanoplates					495:504	ZIF-L nanoplates	489:504	ZIF-L nanoplates	489:504	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	1	45	theme	wastewater	251:260	arg1	treatment					262:270	wastewater treatment	251:270	wastewater treatment	251:270	Fabrication of simple and efficient adsorbents is greatly vital to satisfy the requirements of removal of tellurium in wastewater treatment, yet remains challenging.
34492826	2	46	theme	cellulose	383:391	arg1	membrane					393:400	ZIF-L coated self-crosslinking cellulose membrane	352:400	ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption	352:445	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	2	46	theme	cellulose	383:391	arg1	membrane					412:419	ZIF-L/SC membrane	403:419	ZIF-L/SC membrane	403:419	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	7	47	theme	ZIF-L/SC	1197:1204	arg1	membrane					1206:1213	the ZIF-L/SC membrane	1193:1213	the ZIF-L/SC membrane	1193:1213	Furthermore, the ZIF-L/SC membrane has excellent antibacterial properties, thus it is expected to deal with membrane fouling caused by microorganism breeding.
34492826	8	48	with	membrane	1376:1383	arg1	activity					1414:1421	excellent antibacterial activity	1390:1421	excellent antibacterial activity	1390:1421	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	5	49	theme	contact	931:937	arg1	surface					939:945	large contact surface	925:945	large contact surface	925:945	The as-prepared ZIF-L/SC membrane shows advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength.
34492826	3	50	from	properties	522:531	arg1	substrate					545:553	membrane substrate	536:553	membrane substrate	536:553	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	3	51	theme	pure	617:620	arg1	sorbent					632:638	pure nanosized sorbent	617:638	pure nanosized sorbent	617:638	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	6	52	theme	membrane	1067:1074	arg1	performance					1020:1030	adsorption performance	1009:1030	adsorption performance	1009:1030	The adsorption performance and possible mechanism of ZIF-L/SC membrane for Te (IV) were investigated by diverse characterization methods, showing admirable adsorption effect.
34492826	6	52	theme	membrane	1067:1074	arg1	mechanism					1045:1053	possible mechanism	1036:1053	possible mechanism	1036:1053	The adsorption performance and possible mechanism of ZIF-L/SC membrane for Te (IV) were investigated by diverse characterization methods, showing admirable adsorption effect.
34492826	4	53	theme	hydrogen	720:727	arg1	bonding					729:735	strong hydrogen bonding	713:735	strong hydrogen bonding among cellulose fibers	713:758	The SC membrane formed by strong hydrogen bonding among cellulose fibers is an excellent substrate, due to the favorable mechanical strength and abundant hydroxyl groups.
34492826	5	54	theme	advantageous	898:909	arg1	morphology					911:920	advantageous morphology	898:920	advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength	898:1002	The as-prepared ZIF-L/SC membrane shows advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength.
34492826	3	55	theme	nanosized	622:630	arg1	sorbent					632:638	pure nanosized sorbent	617:638	pure nanosized sorbent	617:638	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	6	56	dep	performance	1020:1030	arg1	The					1005:1007	The	1005:1007	The	1005:1007	The adsorption performance and possible mechanism of ZIF-L/SC membrane for Te (IV) were investigated by diverse characterization methods, showing admirable adsorption effect.
34492826	8	57	theme	bifunctional	1354:1365	arg1	membrane					1376:1383	the bifunctional ZIF-L/SC membrane	1350:1383	the bifunctional ZIF-L/SC membrane with excellent antibacterial activity	1350:1421	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	8	57	theme	bifunctional	1354:1365	arg1	candidate					1456:1464	a promising candidate	1444:1464	a promising candidate for efficient tellurium adsorbents	1444:1499	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	2	58	theme	ZIF-L	352:356	arg1	membrane					393:400	ZIF-L coated self-crosslinking cellulose membrane	352:400	ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption	352:445	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	2	58	theme	ZIF-L	352:356	arg1	membrane					412:419	ZIF-L/SC membrane	403:419	ZIF-L/SC membrane	403:419	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	3	59	theme	agglomeration	643:655	arg1	problem					657:663	agglomeration problem	643:663	agglomeration problem	643:663	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	1	60	theme	removal	227:233	arg1	requirements					211:222	the requirements	207:222	the requirements of removal of tellurium in wastewater treatment	207:270	Fabrication of simple and efficient adsorbents is greatly vital to satisfy the requirements of removal of tellurium in wastewater treatment, yet remains challenging.
34492826	6	61	theme	possible	1036:1043	arg1	mechanism					1045:1053	possible mechanism	1036:1053	possible mechanism	1036:1053	The adsorption performance and possible mechanism of ZIF-L/SC membrane for Te (IV) were investigated by diverse characterization methods, showing admirable adsorption effect.
34492826	7	62	theme	membrane	1288:1295	arg1	fouling					1297:1303	membrane fouling	1288:1303	membrane fouling caused by microorganism breeding	1288:1336	Furthermore, the ZIF-L/SC membrane has excellent antibacterial properties, thus it is expected to deal with membrane fouling caused by microorganism breeding.
34492826	3	63	theme	sorbent	632:638	arg1	deficiency					603:612	deficiency	603:612	deficiency of pure nanosized sorbent	603:638	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	5	64	theme	mechanical	984:993	arg1	strength					995:1002	eligible mechanical strength	975:1002	eligible mechanical strength	975:1002	The as-prepared ZIF-L/SC membrane shows advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength.
34492826	8	65	theme	excellent	1390:1398	arg1	activity					1414:1421	excellent antibacterial activity	1390:1421	excellent antibacterial activity	1390:1421	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	1	66	from	tellurium	238:246	arg1	treatment					262:270	wastewater treatment	251:270	wastewater treatment	251:270	Fabrication of simple and efficient adsorbents is greatly vital to satisfy the requirements of removal of tellurium in wastewater treatment, yet remains challenging.
34492826	1	67	theme	simple	147:152	arg1	adsorbents					168:177	simple and efficient adsorbents	147:177	simple and efficient adsorbents	147:177	Fabrication of simple and efficient adsorbents is greatly vital to satisfy the requirements of removal of tellurium in wastewater treatment, yet remains challenging.
34492826	7	68	theme	microorganism	1315:1327	arg1	breeding					1329:1336	microorganism breeding	1315:1336	microorganism breeding	1315:1336	Furthermore, the ZIF-L/SC membrane has excellent antibacterial properties, thus it is expected to deal with membrane fouling caused by microorganism breeding.
34492826	4	69	theme	SC	691:692	arg1	membrane					694:701	The SC membrane	687:701	The SC membrane formed by strong hydrogen bonding among cellulose fibers	687:758	The SC membrane formed by strong hydrogen bonding among cellulose fibers is an excellent substrate, due to the favorable mechanical strength and abundant hydroxyl groups.
34492826	4	69	theme	SC	691:692	arg1	substrate					776:784	an excellent substrate	763:784	an excellent substrate	763:784	The SC membrane formed by strong hydrogen bonding among cellulose fibers is an excellent substrate, due to the favorable mechanical strength and abundant hydroxyl groups.
34492826	5	70	theme	thermal	953:959	arg1	stability					961:969	fine thermal stability	948:969	fine thermal stability	948:969	The as-prepared ZIF-L/SC membrane shows advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength.
34492826	0	71	theme	tellurium	95:103	arg1	removal					84:90	efficient removal	74:90	efficient removal of tellurium and antibacterial effects	74:129	Facile fabrication of bifunctional ZIF-L/cellulose composite membrane for efficient removal of tellurium and antibacterial effects.
34492826	0	72	theme	antibacterial	109:121	arg1	effects					123:129	antibacterial effects	109:129	antibacterial effects	109:129	Facile fabrication of bifunctional ZIF-L/cellulose composite membrane for efficient removal of tellurium and antibacterial effects.
34492826	4	73	theme	hydroxyl	841:848	arg1	groups					850:855	abundant hydroxyl groups	832:855	abundant hydroxyl groups	832:855	The SC membrane formed by strong hydrogen bonding among cellulose fibers is an excellent substrate, due to the favorable mechanical strength and abundant hydroxyl groups.
34492826	4	74	theme	mechanical	808:817	arg1	strength					819:826	the favorable mechanical strength	794:826	the favorable mechanical strength	794:826	The SC membrane formed by strong hydrogen bonding among cellulose fibers is an excellent substrate, due to the favorable mechanical strength and abundant hydroxyl groups.
34492826	8	75	theme	promising	1446:1454	arg1	membrane					1376:1383	the bifunctional ZIF-L/SC membrane	1350:1383	the bifunctional ZIF-L/SC membrane with excellent antibacterial activity	1350:1421	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	8	75	theme	promising	1446:1454	arg1	candidate					1456:1464	a promising candidate	1444:1464	a promising candidate for efficient tellurium adsorbents	1444:1499	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	5	76	theme	as-prepared	862:872	arg1	membrane					883:890	The as-prepared ZIF-L/SC membrane	858:890	The as-prepared ZIF-L/SC membrane	858:890	The as-prepared ZIF-L/SC membrane shows advantageous morphology of large contact surface, fine thermal stability and eligible mechanical strength.
34492826	6	77	theme	admirable	1151:1159	arg1	effect					1172:1177	admirable adsorption effect	1151:1177	admirable adsorption effect	1151:1177	The adsorption performance and possible mechanism of ZIF-L/SC membrane for Te (IV) were investigated by diverse characterization methods, showing admirable adsorption effect.
34492826	4	78	theme	due	787:789	arg1	membrane					694:701	The SC membrane	687:701	The SC membrane formed by strong hydrogen bonding among cellulose fibers	687:758	The SC membrane formed by strong hydrogen bonding among cellulose fibers is an excellent substrate, due to the favorable mechanical strength and abundant hydroxyl groups.
34492826	4	78	theme	due	787:789	arg1	substrate					776:784	an excellent substrate	763:784	an excellent substrate	763:784	The SC membrane formed by strong hydrogen bonding among cellulose fibers is an excellent substrate, due to the favorable mechanical strength and abundant hydroxyl groups.
34492826	2	79	theme	ZIF-L/SC	403:410	arg1	membrane					393:400	ZIF-L coated self-crosslinking cellulose membrane	352:400	ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption	352:445	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	2	79	theme	ZIF-L/SC	403:410	arg1	membrane					412:419	ZIF-L/SC membrane	403:419	ZIF-L/SC membrane	403:419	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	0	80	theme	bifunctional	22:33	arg1	membrane					61:68	bifunctional ZIF-L/cellulose composite membrane	22:68	bifunctional ZIF-L/cellulose composite membrane	22:68	Facile fabrication of bifunctional ZIF-L/cellulose composite membrane for efficient removal of tellurium and antibacterial effects.
34492826	8	81	theme	efficient	1470:1478	arg1	adsorbents					1490:1499	efficient tellurium adsorbents	1470:1499	efficient tellurium adsorbents	1470:1499	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	0	82	theme	composite	51:59	arg1	membrane					61:68	bifunctional ZIF-L/cellulose composite membrane	22:68	bifunctional ZIF-L/cellulose composite membrane	22:68	Facile fabrication of bifunctional ZIF-L/cellulose composite membrane for efficient removal of tellurium and antibacterial effects.
34492826	6	83	theme	characterization	1117:1132	arg1	methods					1134:1140	diverse characterization methods	1109:1140	diverse characterization methods	1109:1140	The adsorption performance and possible mechanism of ZIF-L/SC membrane for Te (IV) were investigated by diverse characterization methods, showing admirable adsorption effect.
34492826	2	84	theme	tellurium	426:434	arg1	adsorption					436:445	tellurium adsorption	426:445	tellurium adsorption	426:445	Here, a facile and cost-effective strategy to develop ZIF-L coated self-crosslinking cellulose membrane (ZIF-L/SC membrane) for tellurium adsorption was presented.
34492826	7	85	theme	antibacterial	1229:1241	arg1	properties					1243:1252	excellent antibacterial properties	1219:1252	excellent antibacterial properties	1219:1252	Furthermore, the ZIF-L/SC membrane has excellent antibacterial properties, thus it is expected to deal with membrane fouling caused by microorganism breeding.
34492826	8	86	contain	have	1521:1524	arg1	membrane					1376:1383	the bifunctional ZIF-L/SC membrane	1350:1383	the bifunctional ZIF-L/SC membrane with excellent antibacterial activity	1350:1421	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	8	86	contain	have	1521:1524	arg1	candidate					1456:1464	a promising candidate	1444:1464	a promising candidate for efficient tellurium adsorbents	1444:1499	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	8	86	contain	have	1521:1524	arg2	potential					1526:1534	potential	1526:1534	potential	1526:1534	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	3	87	theme	membrane	536:543	arg1	substrate					545:553	membrane substrate	536:553	membrane substrate	536:553	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	8	88	theme	various	1539:1545	arg1	fields					1547:1552	various fields	1539:1552	various fields in the future	1539:1566	Therefore, the bifunctional ZIF-L/SC membrane with excellent antibacterial activity is anticipated to be a promising candidate for efficient tellurium adsorbents, and simultaneously have potential in various fields in the future.
34492826	3	89	theme	available	561:569	arg1	strategy					571:578	an available strategy	558:578	an available strategy	558:578	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34492826	3	89	theme	available	561:569	arg1	growth					479:484	In-situ vertical growth	462:484	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate	462:553	In-situ vertical growth of ZIF-L nanoplates with functional properties on membrane substrate is an available strategy, effectively remedying deficiency of pure nanosized sorbent in agglomeration problem and unhandy recovery.
34388866	4	0	theme	efficient	724:732	arg1	pathway					753:759	an efficient electron transport pathway	721:759	an efficient electron transport pathway for enhanced photocatalytic activity	721:796	The 3D macrostructure not only provides a template for the anchoring of Cu2O and TiO2 but also provides an efficient electron transport pathway for enhanced photocatalytic activity.
34388866	8	1	from	effect	1311:1316	arg1	transfer					1252:1259	the charge transfer and electron-hole separation	1241:1288	transfer	1252:1259	The enhanced photoactivity can be attributed to the charge transfer and electron-hole separation from the synergistic effect of Cu2O/TiO2 anchored on CNF/rGH.
34388866	8	1	from	effect	1311:1316	arg1	separation					1279:1288	the charge transfer and electron-hole separation	1241:1288	separation	1279:1288	The enhanced photoactivity can be attributed to the charge transfer and electron-hole separation from the synergistic effect of Cu2O/TiO2 anchored on CNF/rGH.
34388866	3	2	theme	graphene	540:547	arg1	hydrogel					549:556	a cellulose nanofiber (CNF)/reduced graphene hydrogel	504:556	a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH)	504:562	Herein, we report on the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying.
34388866	3	2	theme	graphene	540:547	arg1	rGH					559:561	rGH	559:561	rGH	559:561	Herein, we report on the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying.
34388866	4	3	theme	3D	621:622	arg1	macrostructure					624:637	The 3D macrostructure	617:637	The 3D macrostructure	617:637	The 3D macrostructure not only provides a template for the anchoring of Cu2O and TiO2 but also provides an efficient electron transport pathway for enhanced photocatalytic activity.
34388866	5	4	theme	actives	955:961	arg1	sites					963:967	exposed actives sites	947:967	exposed actives sites	947:967	The results showed that the Cu2O and TiO2 were uniformly loaded onto the aerogel framework resulting in the composites with large surface area with exposed actives sites.
34388866	1	5	theme	wastewater	190:199	arg1	attention					168:176	attention	168:176	attention	168:176	Photocatalysis has gained attention as a viable wastewater remediation technique.
34388866	1	5	theme	wastewater	190:199	arg1	technique					213:221	a viable wastewater remediation technique	181:221	a viable wastewater remediation technique	181:221	Photocatalysis has gained attention as a viable wastewater remediation technique.
34388866	5	6	with	area	937:940	arg1	sites					963:967	exposed actives sites	947:967	exposed actives sites	947:967	The results showed that the Cu2O and TiO2 were uniformly loaded onto the aerogel framework resulting in the composites with large surface area with exposed actives sites.
34388866	0	7	theme	antibacterial	114:126	arg1	applications					128:139	its antibacterial applications	110:139	its antibacterial applications	110:139	Cu2O/TiO2 decorated on cellulose nanofiber/reduced graphene hydrogel for enhanced photocatalytic activity and its antibacterial applications.
34388866	2	8	theme	on-site	335:341	arg1	application					353:363	their on-site practical application	329:363	their on-site practical application	329:363	However, the difficulty of recovering powder-based photocatalyst has often become a major limitation for their on-site practical application.
34388866	8	9	theme	enhanced	1197:1204	arg1	photoactivity					1206:1218	The enhanced photoactivity	1193:1218	The enhanced photoactivity	1193:1218	The enhanced photoactivity can be attributed to the charge transfer and electron-hole separation from the synergistic effect of Cu2O/TiO2 anchored on CNF/rGH.
34388866	3	10	theme	hydrothermal	575:586	arg1	treatment					588:596	facile hydrothermal treatment	568:596	facile hydrothermal treatment	568:596	Herein, we report on the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying.
34388866	1	11	theme	viable	183:188	arg1	attention					168:176	attention	168:176	attention	168:176	Photocatalysis has gained attention as a viable wastewater remediation technique.
34388866	1	11	theme	viable	183:188	arg1	technique					213:221	a viable wastewater remediation technique	181:221	a viable wastewater remediation technique	181:221	Photocatalysis has gained attention as a viable wastewater remediation technique.
34388866	5	12	theme	exposed	947:953	arg1	sites					963:967	exposed actives sites	947:967	exposed actives sites	947:967	The results showed that the Cu2O and TiO2 were uniformly loaded onto the aerogel framework resulting in the composites with large surface area with exposed actives sites.
34388866	7	13	theme	MO	1133:1134	arg1	pathway					1148:1154	MO degradation pathway	1133:1154	MO degradation pathway	1133:1154	MO degradation pathway is proposed based on GC-MS analysis.
34388866	1	14	theme	remediation	201:211	arg1	attention					168:176	attention	168:176	attention	168:176	Photocatalysis has gained attention as a viable wastewater remediation technique.
34388866	1	14	theme	remediation	201:211	arg1	technique					213:221	a viable wastewater remediation technique	181:221	a viable wastewater remediation technique	181:221	Photocatalysis has gained attention as a viable wastewater remediation technique.
34388866	3	15	theme	successful	391:400	arg1	preparation					410:420	the successful in-situ preparation	387:420	the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying	387:614	Herein, we report on the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying.
34388866	7	16	theme	degradation	1136:1146	arg1	pathway					1148:1154	MO degradation pathway	1133:1154	MO degradation pathway	1133:1154	MO degradation pathway is proposed based on GC-MS analysis.
34388866	9	17	theme	synergistic	1450:1460	arg1	effect					1462:1467	the synergistic effect	1446:1467	the synergistic effect of the Cu2O/TiO2 anchored on the CNF/rGH framework	1446:1518	In terms of their anti-bacterial activity towards Staphylococcus aureus and Escherichia coli, the synergistic effect of the Cu2O/TiO2 anchored on the CNF/rGH framework showed excellent activity towards the bacteria.
34388866	4	18	theme	Cu2O	689:692	arg1	anchoring					676:684	the anchoring	672:684	the anchoring of Cu2O and TiO2	672:701	The 3D macrostructure not only provides a template for the anchoring of Cu2O and TiO2 but also provides an efficient electron transport pathway for enhanced photocatalytic activity.
34388866	3	19	theme	novel	427:431	arg1	photocatalyst					456:468	a novel three-dimensional (3D) photocatalyst	425:468	a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying	425:614	Herein, we report on the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying.
34388866	9	20	theme	anti-bacterial	1370:1383	arg1	activity					1385:1392	their anti-bacterial activity	1364:1392	their anti-bacterial activity towards Staphylococcus aureus and Escherichia coli	1364:1443	In terms of their anti-bacterial activity towards Staphylococcus aureus and Escherichia coli, the synergistic effect of the Cu2O/TiO2 anchored on the CNF/rGH framework showed excellent activity towards the bacteria.
34388866	4	21	theme	photocatalytic	774:787	arg1	activity					789:796	enhanced photocatalytic activity	765:796	enhanced photocatalytic activity	765:796	The 3D macrostructure not only provides a template for the anchoring of Cu2O and TiO2 but also provides an efficient electron transport pathway for enhanced photocatalytic activity.
34388866	8	22	theme	synergistic	1299:1309	arg1	effect					1311:1316	the synergistic effect	1295:1316	the synergistic effect of Cu2O/TiO2 anchored on CNF/rGH	1295:1349	The enhanced photoactivity can be attributed to the charge transfer and electron-hole separation from the synergistic effect of Cu2O/TiO2 anchored on CNF/rGH.
34388866	3	23	theme	three-dimensional	433:449	arg1	photocatalyst					456:468	a novel three-dimensional (3D) photocatalyst	425:468	a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying	425:614	Herein, we report on the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying.
34388866	9	24	theme	activity	1385:1392	arg1	terms					1355:1359	terms	1355:1359	terms of their anti-bacterial activity towards Staphylococcus aureus and Escherichia coli	1355:1443	In terms of their anti-bacterial activity towards Staphylococcus aureus and Escherichia coli, the synergistic effect of the Cu2O/TiO2 anchored on the CNF/rGH framework showed excellent activity towards the bacteria.
34388866	3	25	dep	three-dimensional	433:449	arg1	3D					452:453	3D	452:453	3D	452:453	Herein, we report on the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying.
34388866	4	26	theme	enhanced	765:772	arg1	activity					789:796	enhanced photocatalytic activity	765:796	enhanced photocatalytic activity	765:796	The 3D macrostructure not only provides a template for the anchoring of Cu2O and TiO2 but also provides an efficient electron transport pathway for enhanced photocatalytic activity.
34388866	4	27	theme	TiO2	698:701	arg1	anchoring					676:684	the anchoring	672:684	the anchoring of Cu2O and TiO2	672:701	The 3D macrostructure not only provides a template for the anchoring of Cu2O and TiO2 but also provides an efficient electron transport pathway for enhanced photocatalytic activity.
34388866	0	28	theme	cellulose	23:31	arg1	hydrogel					60:67	cellulose nanofiber/reduced graphene hydrogel	23:67	cellulose nanofiber/reduced graphene hydrogel for enhanced photocatalytic activity and its antibacterial applications	23:139	Cu2O/TiO2 decorated on cellulose nanofiber/reduced graphene hydrogel for enhanced photocatalytic activity and its antibacterial applications.
34388866	6	29	theme	methyl	1101:1106	arg1	MO					1116:1117	MO	1116:1117	MO	1116:1117	As compared to bare rGH, CNF/rGH, Cu2O/CNF/rGH and TiO2/CNF/rGH, the Cu2O/TiO2/CNF/rGH showed improved photocatalytic activity for methyl orange (MO) degradation.
34388866	6	29	theme	methyl	1101:1106	arg1	orange					1108:1113	methyl orange	1101:1113	methyl orange (MO) degradation	1101:1130	As compared to bare rGH, CNF/rGH, Cu2O/CNF/rGH and TiO2/CNF/rGH, the Cu2O/TiO2/CNF/rGH showed improved photocatalytic activity for methyl orange (MO) degradation.
34388866	2	30	theme	practical	343:351	arg1	application					353:363	their on-site practical application	329:363	their on-site practical application	329:363	However, the difficulty of recovering powder-based photocatalyst has often become a major limitation for their on-site practical application.
34388866	5	31	theme	aerogel	872:878	arg1	framework					880:888	the aerogel framework	868:888	the aerogel framework resulting in the composites with large surface area with exposed actives sites	868:967	The results showed that the Cu2O and TiO2 were uniformly loaded onto the aerogel framework resulting in the composites with large surface area with exposed actives sites.
34388866	0	32	theme	graphene	51:58	arg1	hydrogel					60:67	cellulose nanofiber/reduced graphene hydrogel	23:67	cellulose nanofiber/reduced graphene hydrogel for enhanced photocatalytic activity and its antibacterial applications	23:139	Cu2O/TiO2 decorated on cellulose nanofiber/reduced graphene hydrogel for enhanced photocatalytic activity and its antibacterial applications.
34388866	4	33	theme	electron	734:741	arg1	pathway					753:759	an efficient electron transport pathway	721:759	an efficient electron transport pathway for enhanced photocatalytic activity	721:796	The 3D macrostructure not only provides a template for the anchoring of Cu2O and TiO2 but also provides an efficient electron transport pathway for enhanced photocatalytic activity.
34388866	6	34	theme	orange	1108:1113	arg1	degradation					1120:1130	methyl orange (MO) degradation	1101:1130	methyl orange (MO) degradation	1101:1130	As compared to bare rGH, CNF/rGH, Cu2O/CNF/rGH and TiO2/CNF/rGH, the Cu2O/TiO2/CNF/rGH showed improved photocatalytic activity for methyl orange (MO) degradation.
34388866	0	35	theme	nanofiber/reduced	33:49	arg1	hydrogel					60:67	cellulose nanofiber/reduced graphene hydrogel	23:67	cellulose nanofiber/reduced graphene hydrogel for enhanced photocatalytic activity and its antibacterial applications	23:139	Cu2O/TiO2 decorated on cellulose nanofiber/reduced graphene hydrogel for enhanced photocatalytic activity and its antibacterial applications.
34388866	6	36	theme	bare	985:988	arg1	rGH					990:992	bare rGH	985:992	bare rGH	985:992	As compared to bare rGH, CNF/rGH, Cu2O/CNF/rGH and TiO2/CNF/rGH, the Cu2O/TiO2/CNF/rGH showed improved photocatalytic activity for methyl orange (MO) degradation.
34388866	3	37	theme	photocatalyst	456:468	arg1	preparation					410:420	the successful in-situ preparation	387:420	the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying	387:614	Herein, we report on the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying.
34388866	2	38	theme	photocatalyst	275:287	arg1	difficulty					237:246	the difficulty	233:246	the difficulty of recovering powder-based photocatalyst	233:287	However, the difficulty of recovering powder-based photocatalyst has often become a major limitation for their on-site practical application.
34388866	6	39	theme	photocatalytic	1073:1086	arg1	activity					1088:1095	improved photocatalytic activity	1064:1095	improved photocatalytic activity for methyl orange (MO) degradation	1064:1130	As compared to bare rGH, CNF/rGH, Cu2O/CNF/rGH and TiO2/CNF/rGH, the Cu2O/TiO2/CNF/rGH showed improved photocatalytic activity for methyl orange (MO) degradation.
34388866	8	40	theme	electron-hole	1265:1277	arg1	separation					1279:1288	the charge transfer and electron-hole separation	1241:1288	separation	1279:1288	The enhanced photoactivity can be attributed to the charge transfer and electron-hole separation from the synergistic effect of Cu2O/TiO2 anchored on CNF/rGH.
34388866	3	41	theme	in-situ	402:408	arg1	preparation					410:420	the successful in-situ preparation	387:420	the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying	387:614	Herein, we report on the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying.
34388866	5	42	with	composites	907:916	arg1	area					937:940	large surface area	923:940	large surface area with exposed actives sites	923:967	The results showed that the Cu2O and TiO2 were uniformly loaded onto the aerogel framework resulting in the composites with large surface area with exposed actives sites.
34388866	2	43	theme	powder-based	262:273	arg1	photocatalyst					275:287	recovering powder-based photocatalyst	251:287	recovering powder-based photocatalyst	251:287	However, the difficulty of recovering powder-based photocatalyst has often become a major limitation for their on-site practical application.
34388866	4	44	theme	transport	743:751	arg1	pathway					753:759	an efficient electron transport pathway	721:759	an efficient electron transport pathway for enhanced photocatalytic activity	721:796	The 3D macrostructure not only provides a template for the anchoring of Cu2O and TiO2 but also provides an efficient electron transport pathway for enhanced photocatalytic activity.
34388866	7	45	theme	GC-MS	1177:1181	arg1	analysis					1183:1190	GC-MS analysis	1177:1190	GC-MS analysis	1177:1190	MO degradation pathway is proposed based on GC-MS analysis.
34388866	2	46	theme	recovering	251:260	arg1	photocatalyst					275:287	recovering powder-based photocatalyst	251:287	recovering powder-based photocatalyst	251:287	However, the difficulty of recovering powder-based photocatalyst has often become a major limitation for their on-site practical application.
34388866	3	47	theme	/reduced	531:538	arg1	hydrogel					549:556	a cellulose nanofiber (CNF)/reduced graphene hydrogel	504:556	a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH)	504:562	Herein, we report on the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying.
34388866	3	47	theme	/reduced	531:538	arg1	rGH					559:561	rGH	559:561	rGH	559:561	Herein, we report on the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying.
34388866	2	48	theme	major	308:312	arg1	limitation					314:323	a major limitation	306:323	a major limitation for their on-site practical application	306:363	However, the difficulty of recovering powder-based photocatalyst has often become a major limitation for their on-site practical application.
34388866	6	49	theme	improved	1064:1071	arg1	activity					1088:1095	improved photocatalytic activity	1064:1095	improved photocatalytic activity for methyl orange (MO) degradation	1064:1130	As compared to bare rGH, CNF/rGH, Cu2O/CNF/rGH and TiO2/CNF/rGH, the Cu2O/TiO2/CNF/rGH showed improved photocatalytic activity for methyl orange (MO) degradation.
34388866	9	50	theme	Cu2O/TiO2	1476:1484	arg1	effect					1462:1467	the synergistic effect	1446:1467	the synergistic effect of the Cu2O/TiO2 anchored on the CNF/rGH framework	1446:1518	In terms of their anti-bacterial activity towards Staphylococcus aureus and Escherichia coli, the synergistic effect of the Cu2O/TiO2 anchored on the CNF/rGH framework showed excellent activity towards the bacteria.
34388866	3	51	theme	facile	568:573	arg1	treatment					588:596	facile hydrothermal treatment	568:596	facile hydrothermal treatment	568:596	Herein, we report on the successful in-situ preparation of a novel three-dimensional (3D) photocatalyst consisting of Cu2O/TiO2 loaded on a cellulose nanofiber (CNF)/reduced graphene hydrogel (rGH) via facile hydrothermal treatment and freeze-drying.
34388866	8	52	theme	charge	1245:1250	arg1	transfer					1252:1259	the charge transfer and electron-hole separation	1241:1288	transfer	1252:1259	The enhanced photoactivity can be attributed to the charge transfer and electron-hole separation from the synergistic effect of Cu2O/TiO2 anchored on CNF/rGH.
34388866	0	53	theme	photocatalytic	82:95	arg1	activity					97:104	enhanced photocatalytic activity	73:104	enhanced photocatalytic activity	73:104	Cu2O/TiO2 decorated on cellulose nanofiber/reduced graphene hydrogel for enhanced photocatalytic activity and its antibacterial applications.
34388866	8	54	theme	Cu2O/TiO2	1321:1329	arg1	effect					1311:1316	the synergistic effect	1295:1316	the synergistic effect of Cu2O/TiO2 anchored on CNF/rGH	1295:1349	The enhanced photoactivity can be attributed to the charge transfer and electron-hole separation from the synergistic effect of Cu2O/TiO2 anchored on CNF/rGH.
34388866	9	55	theme	excellent	1527:1535	arg1	activity					1537:1544	excellent activity	1527:1544	excellent activity towards the bacteria	1527:1565	In terms of their anti-bacterial activity towards Staphylococcus aureus and Escherichia coli, the synergistic effect of the Cu2O/TiO2 anchored on the CNF/rGH framework showed excellent activity towards the bacteria.
34388866	5	56	theme	large	923:927	arg1	area					937:940	large surface area	923:940	large surface area with exposed actives sites	923:967	The results showed that the Cu2O and TiO2 were uniformly loaded onto the aerogel framework resulting in the composites with large surface area with exposed actives sites.
34388866	9	57	theme	CNF/rGH	1502:1508	arg1	framework					1510:1518	the CNF/rGH framework	1498:1518	the CNF/rGH framework	1498:1518	In terms of their anti-bacterial activity towards Staphylococcus aureus and Escherichia coli, the synergistic effect of the Cu2O/TiO2 anchored on the CNF/rGH framework showed excellent activity towards the bacteria.
34388866	0	58	theme	enhanced	73:80	arg1	activity					97:104	enhanced photocatalytic activity	73:104	enhanced photocatalytic activity	73:104	Cu2O/TiO2 decorated on cellulose nanofiber/reduced graphene hydrogel for enhanced photocatalytic activity and its antibacterial applications.
34388866	5	59	theme	surface	929:935	arg1	area					937:940	large surface area	923:940	large surface area with exposed actives sites	923:967	The results showed that the Cu2O and TiO2 were uniformly loaded onto the aerogel framework resulting in the composites with large surface area with exposed actives sites.
33338530	3	0	theme	bacteria	667:674	arg1	counts					676:681	bacteria counts	667:681	bacteria counts	667:681	and H2S-producing bacteria counts, and inhibit the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds.
33338530	1	1	theme	Scophthalmus	238:249	arg1	turbot					230:235	turbot	230:235	turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1)	230:412	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	1	1	theme	Scophthalmus	238:249	arg1	maximus					251:257	Scophthalmus maximus	238:257	Scophthalmus maximus	238:257	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	5	2	theme	LBG-SA	1119:1124	arg1	coatings					1126:1133	the LBG-SA coatings	1115:1133	the LBG-SA coatings containing daphnetin	1115:1154	Further, the LBG-SA coatings containing daphnetin could also delay the myofibril degradation of the turbot samples.
33338530	6	3	theme	turbot	1358:1363	arg1	quality					1347:1353	the quality	1343:1353	the quality of turbot	1343:1363	These results indicated that the LBG-SA coatings with 0.32 mg·mL-1 daphnetin were a potential alternative way to improve the quality of turbot during refrigerated storage.
33338530	3	4	theme	ATP-related	814:824	arg1	compounds					826:834	ATP-related compounds	814:834	ATP-related compounds	814:834	and H2S-producing bacteria counts, and inhibit the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds.
33338530	1	5	dep	0.16	388:391	arg1	0.64 mg·mL-1					400:411	0.64 mg·mL-1	400:411	0.64 mg·mL-1	400:411	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	1	5	dep	0.16	388:391	arg1	0.32					394:397	0.32	394:397	0.32	394:397	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	6	6	theme	refrigerated	1372:1383	arg1	storage					1385:1391	refrigerated storage	1372:1391	refrigerated storage	1372:1391	These results indicated that the LBG-SA coatings with 0.32 mg·mL-1 daphnetin were a potential alternative way to improve the quality of turbot during refrigerated storage.
33338530	6	7	theme	0.32 mg·mL-1	1276:1287	arg1	daphnetin					1289:1297	0.32 mg·mL-1 daphnetin	1276:1297	0.32 mg·mL-1 daphnetin	1276:1297	These results indicated that the LBG-SA coatings with 0.32 mg·mL-1 daphnetin were a potential alternative way to improve the quality of turbot during refrigerated storage.
33338530	5	8	theme	turbot	1206:1211	arg1	samples					1213:1219	the turbot samples	1202:1219	the turbot samples	1202:1219	Further, the LBG-SA coatings containing daphnetin could also delay the myofibril degradation of the turbot samples.
33338530	5	9	theme	samples	1213:1219	arg1	degradation					1187:1197	the myofibril degradation	1173:1197	the myofibril degradation of the turbot samples	1173:1219	Further, the LBG-SA coatings containing daphnetin could also delay the myofibril degradation of the turbot samples.
33338530	0	10	theme	Scophthalmus	107:118	arg1	maximus					120:126	Scophthalmus maximus	107:126	Scophthalmus maximus	107:126	Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition.
33338530	1	11	theme	sodium	328:333	arg1	SA					345:346	SA	345:346	SA	345:346	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	1	11	theme	sodium	328:333	arg1	alginate					335:342	sodium alginate	328:342	sodium alginate (SA)	328:347	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	6	12	theme	alternative	1316:1326	arg1	way					1328:1330	a potential alternative way	1304:1330	a potential alternative way to improve the quality of turbot during refrigerated storage	1304:1391	These results indicated that the LBG-SA coatings with 0.32 mg·mL-1 daphnetin were a potential alternative way to improve the quality of turbot during refrigerated storage.
33338530	6	12	theme	alternative	1316:1326	arg1	coatings					1262:1269	the LBG-SA coatings	1251:1269	the LBG-SA coatings with 0.32 mg·mL-1 daphnetin	1251:1297	These results indicated that the LBG-SA coatings with 0.32 mg·mL-1 daphnetin were a potential alternative way to improve the quality of turbot during refrigerated storage.
33338530	4	13	theme	gas	920:922	arg1	method					957:962	gas chromatography-mass spectrometer method	920:962	gas chromatography-mass spectrometer method (SPME-GC/MS)	920:975	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	4	13	theme	gas	920:922	arg1	SPME-GC/MS					965:974	SPME-GC/MS	965:974	SPME-GC/MS	965:974	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	1	14	theme	alginate	335:342	arg1	coating					291:297	a composite active coating	272:297	a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1)	272:412	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	2	15	theme	viable	597:602	arg1	spp					644:646	Pseudomonas spp	632:646	Pseudomonas spp	632:646	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	2	15	theme	viable	597:602	arg1	TVC					611:613	TVC	611:613	TVC	611:613	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	2	15	theme	viable	597:602	arg1	psychrophiles					617:629	psychrophiles	617:629	psychrophiles	617:629	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	2	15	theme	viable	597:602	arg1	count					604:608	the total viable count	587:608	the total viable count (TVC)	587:614	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	5	16	theme	myofibril	1177:1185	arg1	degradation					1187:1197	the myofibril degradation	1173:1197	the myofibril degradation of the turbot samples	1173:1219	Further, the LBG-SA coatings containing daphnetin could also delay the myofibril degradation of the turbot samples.
33338530	3	17	theme	compounds	726:734	arg1	productions					700:710	the productions	696:710	the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds	696:834	and H2S-producing bacteria counts, and inhibit the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds.
33338530	2	18	theme	total	591:595	arg1	spp					644:646	Pseudomonas spp	632:646	Pseudomonas spp	632:646	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	2	18	theme	total	591:595	arg1	TVC					611:613	TVC	611:613	TVC	611:613	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	2	18	theme	total	591:595	arg1	psychrophiles					617:629	psychrophiles	617:629	psychrophiles	617:629	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	2	18	theme	total	591:595	arg1	count					604:608	the total viable count	587:608	the total viable count (TVC)	587:614	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	4	19	theme	volatile	840:847	arg1	compounds					849:857	32 volatile compounds	837:857	32 volatile compounds	837:857	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	1	20	theme	microbiological	174:188	arg1	changes					219:225	the microbiological, physicochemical, and flavor changes	170:225	the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1)	170:412	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	4	21	theme	compounds	1095:1103	arg1	content					1071:1077	the relative content	1058:1077	the relative content of fishy flavor compounds	1058:1103	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	0	22	theme	bean	17:20	arg1	coatings					42:49	locust bean gum-sodium alginate coatings	10:49	locust bean gum-sodium alginate coatings	10:49	Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition.
33338530	3	23	theme	off-flavor	715:724	arg1	nitrogen					771:778	the total volatile basic nitrogen	746:778	the total volatile basic nitrogen (TVB-N)	746:786	and H2S-producing bacteria counts, and inhibit the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds.
33338530	3	23	theme	off-flavor	715:724	arg1	compounds					826:834	ATP-related compounds	814:834	ATP-related compounds	814:834	and H2S-producing bacteria counts, and inhibit the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds.
33338530	3	23	theme	off-flavor	715:724	arg1	compounds					726:734	off-flavor compounds	715:734	off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds	715:834	and H2S-producing bacteria counts, and inhibit the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds.
33338530	3	23	theme	off-flavor	715:724	arg1	trimethylamine					789:802	trimethylamine	789:802	trimethylamine (TMA)	789:808	and H2S-producing bacteria counts, and inhibit the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds.
33338530	2	24	theme	LBG-SA	501:506	arg1	coatings					508:515	LBG-SA coatings	501:515	LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions	501:559	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	2	25	contain	containing	517:526	arg2	emulsions					551:559	0.32 mg·mL-1 daphnetin emulsions	528:559	0.32 mg·mL-1 daphnetin emulsions	528:559	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	2	25	contain	containing	517:526	arg1	coatings					508:515	LBG-SA coatings	501:515	LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions	501:559	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	1	26	theme	physicochemical	191:205	arg1	changes					219:225	the microbiological, physicochemical, and flavor changes	170:225	the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1)	170:412	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	0	27	theme	locust	10:15	arg1	coatings					42:49	locust bean gum-sodium alginate coatings	10:49	locust bean gum-sodium alginate coatings	10:49	Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition.
33338530	1	28	theme	composite	274:282	arg1	coating					291:297	a composite active coating	272:297	a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1)	272:412	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	0	29	theme	maximus	120:126	arg1	quality					96:102	the quality	92:102	the quality of Scophthalmus maximus at refrigerated condition	92:152	Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition.
33338530	4	30	theme	phase	884:888	arg1	microextraction					890:904	solid phase microextraction	878:904	solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS)	878:975	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	0	31	theme	alginate	33:40	arg1	coatings					42:49	locust bean gum-sodium alginate coatings	10:49	locust bean gum-sodium alginate coatings	10:49	Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition.
33338530	1	32	theme	active	284:289	arg1	coating					291:297	a composite active coating	272:297	a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1)	272:412	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	0	33	from	emulsions	79:87	arg1	quality					96:102	the quality	92:102	the quality of Scophthalmus maximus at refrigerated condition	92:152	Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition.
33338530	4	34	theme	turbot	1021:1026	arg1	samples					1028:1034	the treated turbot samples	1009:1034	the treated turbot samples	1009:1034	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	0	35	theme	gum-sodium	22:31	arg1	coatings					42:49	locust bean gum-sodium alginate coatings	10:49	locust bean gum-sodium alginate coatings	10:49	Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition.
33338530	4	36	theme	refrigerated	984:995	arg1	storage					997:1003	refrigerated storage	984:1003	refrigerated storage	984:1003	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	0	37	theme	refrigerated	131:142	arg1	condition					144:152	refrigerated condition	131:152	refrigerated condition	131:152	Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition.
33338530	2	38	dep	count	604:608	arg1	lower					581:585	lower	581:585	lower	581:585	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	1	39	theme	flavor	212:217	arg1	changes					219:225	the microbiological, physicochemical, and flavor changes	170:225	the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1)	170:412	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	3	40	theme	total	750:754	arg1	nitrogen					771:778	the total volatile basic nitrogen	746:778	the total volatile basic nitrogen (TVB-N)	746:786	and H2S-producing bacteria counts, and inhibit the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds.
33338530	3	40	theme	total	750:754	arg1	TVB-N					781:785	TVB-N	781:785	TVB-N	781:785	and H2S-producing bacteria counts, and inhibit the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds.
33338530	2	41	theme	daphnetin	541:549	arg1	emulsions					551:559	0.32 mg·mL-1 daphnetin emulsions	528:559	0.32 mg·mL-1 daphnetin emulsions	528:559	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	6	42	with	coatings	1262:1269	arg1	daphnetin					1289:1297	0.32 mg·mL-1 daphnetin	1276:1297	0.32 mg·mL-1 daphnetin	1276:1297	These results indicated that the LBG-SA coatings with 0.32 mg·mL-1 daphnetin were a potential alternative way to improve the quality of turbot during refrigerated storage.
33338530	0	43	theme	coatings	42:49	arg1	Effect					0:5	Effect	0:5	Effect of locust bean gum-sodium alginate coatings	0:49	Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition.
33338530	1	44	theme	locust	302:307	arg1	LBG					319:321	LBG	319:321	LBG	319:321	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	1	44	theme	locust	302:307	arg1	gum					314:316	locust bean gum	302:316	locust bean gum (LBG)	302:322	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	1	44	theme	locust	302:307	arg1	0.16					388:391	0.16	388:391	0.16	388:391	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	2	45	theme	0.32 mg·mL-1	528:539	arg1	emulsions					551:559	0.32 mg·mL-1 daphnetin emulsions	528:559	0.32 mg·mL-1 daphnetin emulsions	528:559	Results showed that LBG-SA coatings containing 0.32 mg·mL-1 daphnetin emulsions could significantly lower the total viable count (TVC), psychrophiles, Pseudomonas spp.
33338530	1	46	theme	daphnetin	367:375	arg1	emulsions					377:385	daphnetin emulsions	367:385	daphnetin emulsions	367:385	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	6	47	theme	LBG-SA	1255:1260	arg1	way					1328:1330	a potential alternative way	1304:1330	a potential alternative way to improve the quality of turbot during refrigerated storage	1304:1391	These results indicated that the LBG-SA coatings with 0.32 mg·mL-1 daphnetin were a potential alternative way to improve the quality of turbot during refrigerated storage.
33338530	6	47	theme	LBG-SA	1255:1260	arg1	coatings					1262:1269	the LBG-SA coatings	1251:1269	the LBG-SA coatings with 0.32 mg·mL-1 daphnetin	1251:1297	These results indicated that the LBG-SA coatings with 0.32 mg·mL-1 daphnetin were a potential alternative way to improve the quality of turbot during refrigerated storage.
33338530	1	48	theme	refrigerated	448:459	arg1	4 ± 1 °C					470:477	4 ± 1 °C	470:477	4 ± 1 °C	470:477	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	1	48	theme	refrigerated	448:459	arg1	storage					461:467	refrigerated storage	448:467	refrigerated storage (4 ± 1 °C)	448:478	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	4	49	theme	chromatography-mass	924:942	arg1	method					957:962	gas chromatography-mass spectrometer method	920:962	gas chromatography-mass spectrometer method (SPME-GC/MS)	920:975	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	4	49	theme	chromatography-mass	924:942	arg1	SPME-GC/MS					965:974	SPME-GC/MS	965:974	SPME-GC/MS	965:974	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	1	50	theme	bean	309:312	arg1	LBG					319:321	LBG	319:321	LBG	319:321	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	1	50	theme	bean	309:312	arg1	gum					314:316	locust bean gum	302:316	locust bean gum (LBG)	302:322	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	1	50	theme	bean	309:312	arg1	0.16					388:391	0.16	388:391	0.16	388:391	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	6	51	theme	potential	1306:1314	arg1	way					1328:1330	a potential alternative way	1304:1330	a potential alternative way to improve the quality of turbot during refrigerated storage	1304:1391	These results indicated that the LBG-SA coatings with 0.32 mg·mL-1 daphnetin were a potential alternative way to improve the quality of turbot during refrigerated storage.
33338530	6	51	theme	potential	1306:1314	arg1	coatings					1262:1269	the LBG-SA coatings	1251:1269	the LBG-SA coatings with 0.32 mg·mL-1 daphnetin	1251:1297	These results indicated that the LBG-SA coatings with 0.32 mg·mL-1 daphnetin were a potential alternative way to improve the quality of turbot during refrigerated storage.
33338530	1	52	theme	storage	461:467	arg1	18 days					437:443	18 days	437:443	18 days of refrigerated storage (4 ± 1 °C)	437:478	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	4	53	theme	relative	1062:1069	arg1	content					1071:1077	the relative content	1058:1077	the relative content of fishy flavor compounds	1058:1103	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	0	54	from	condition	144:152	arg1	quality					96:102	the quality	92:102	the quality of Scophthalmus maximus at refrigerated condition	92:152	Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition.
33338530	5	55	contain	containing	1135:1144	arg2	daphnetin					1146:1154	daphnetin	1146:1154	daphnetin	1146:1154	Further, the LBG-SA coatings containing daphnetin could also delay the myofibril degradation of the turbot samples.
33338530	5	55	contain	containing	1135:1144	arg1	coatings					1126:1133	the LBG-SA coatings	1115:1133	the LBG-SA coatings containing daphnetin	1115:1154	Further, the LBG-SA coatings containing daphnetin could also delay the myofibril degradation of the turbot samples.
33338530	4	56	theme	flavor	1088:1093	arg1	compounds					1095:1103	fishy flavor compounds	1082:1103	fishy flavor compounds	1082:1103	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	4	57	theme	fishy	1082:1086	arg1	compounds					1095:1103	fishy flavor compounds	1082:1103	fishy flavor compounds	1082:1103	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	0	58	theme	daphnetin	69:77	arg1	emulsions					79:87	daphnetin emulsions	69:87	daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition	69:152	Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition.
33338530	4	59	theme	solid	878:882	arg1	microextraction					890:904	solid phase microextraction	878:904	solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS)	878:975	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	3	60	theme	volatile	756:763	arg1	nitrogen					771:778	the total volatile basic nitrogen	746:778	the total volatile basic nitrogen (TVB-N)	746:786	and H2S-producing bacteria counts, and inhibit the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds.
33338530	3	60	theme	volatile	756:763	arg1	TVB-N					781:785	TVB-N	781:785	TVB-N	781:785	and H2S-producing bacteria counts, and inhibit the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds.
33338530	1	61	theme	turbot	230:235	arg1	changes					219:225	the microbiological, physicochemical, and flavor changes	170:225	the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1)	170:412	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	4	62	theme	spectrometer	944:955	arg1	method					957:962	gas chromatography-mass spectrometer method	920:962	gas chromatography-mass spectrometer method (SPME-GC/MS)	920:975	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	4	62	theme	spectrometer	944:955	arg1	SPME-GC/MS					965:974	SPME-GC/MS	965:974	SPME-GC/MS	965:974	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	1	63	theme	gum	314:316	arg1	coating					291:297	a composite active coating	272:297	a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1)	272:412	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	4	64	theme	treated	1013:1019	arg1	samples					1028:1034	the treated turbot samples	1009:1034	the treated turbot samples	1009:1034	32 volatile compounds were identified by solid phase microextraction combined with gas chromatography-mass spectrometer method (SPME-GC/MS) during refrigerated storage and the treated turbot samples significantly lowered the relative content of fishy flavor compounds.
33338530	1	65	dep	supplemented	349:360	arg1	gum					314:316	locust bean gum	302:316	locust bean gum (LBG)	302:322	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	1	65	dep	supplemented	349:360	arg1	0.16					388:391	0.16	388:391	0.16	388:391	In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± 1 °C).
33338530	3	66	theme	basic	765:769	arg1	nitrogen					771:778	the total volatile basic nitrogen	746:778	the total volatile basic nitrogen (TVB-N)	746:786	and H2S-producing bacteria counts, and inhibit the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds.
33338530	3	66	theme	basic	765:769	arg1	TVB-N					781:785	TVB-N	781:785	TVB-N	781:785	and H2S-producing bacteria counts, and inhibit the productions of off-flavor compounds including the total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and ATP-related compounds.
32623331	0	0	theme	colloid	94:100	arg1	scale					107:111	the colloid size scale	90:111	the colloid size scale	90:111	Mucoadhesive interactions between synthetic polyaspartamides and porcine gastric mucin on the colloid size scale.
32623331	0	1	from	interactions	13:24	arg1	scale					107:111	the colloid size scale	90:111	the colloid size scale	90:111	Mucoadhesive interactions between synthetic polyaspartamides and porcine gastric mucin on the colloid size scale.
32623331	1	2	theme	primary	187:193	arg1	amine					216:220	primary, secondary, tertiary amine	187:220	primary, secondary, tertiary amine	187:220	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	4	3	with	interactions	628:639	arg1	dispersion					674:683	the aqueous dispersion	662:683	the aqueous dispersion of commercially available porcine gastric mucin	662:731	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	0	4	theme	size	102:105	arg1	scale					107:111	the colloid size scale	90:111	the colloid size scale	90:111	Mucoadhesive interactions between synthetic polyaspartamides and porcine gastric mucin on the colloid size scale.
32623331	7	5	from	useful	1210:1215	arg1	design					1224:1229	the design	1220:1229	the design of mucoadhesive formulations	1220:1258	The results obtained allow us to classify these polymers in terms of in vitro mucoadhesive strength, which can be useful in the design of mucoadhesive formulations.
32623331	5	6	theme	pronounced	953:962	arg1	effect					964:969	a pronounced effect	951:969	a pronounced effect	951:969	Both the charge of the polymers and the type of amine groups had a pronounced effect on the interactions.
32623331	3	7	theme	strong	545:550	arg1	interaction					552:562	its strong interaction	541:562	its strong interaction with mucin primarily through electrostatic forces	541:612	Chitosan was used as a control sample due to its strong interaction with mucin primarily through electrostatic forces.
32623331	1	8	theme	chemical	280:287	arg1	composition					289:299	chemical composition	280:299	chemical composition	280:299	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	4	9	theme	mucin	727:731	arg1	dispersion					674:683	the aqueous dispersion	662:683	the aqueous dispersion of commercially available porcine gastric mucin	662:731	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	5	10	theme	groups	940:945	arg1	charge					895:900	the charge	891:900	the charge of the polymers	891:916	Both the charge of the polymers and the type of amine groups had a pronounced effect on the interactions.
32623331	5	10	theme	groups	940:945	arg1	type					926:929	the type	922:929	the type of amine groups	922:945	Both the charge of the polymers and the type of amine groups had a pronounced effect on the interactions.
32623331	4	11	theme	polymers	648:655	arg1	interactions					628:639	Mucoadhesive interactions	615:639	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin	615:731	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	3	12	theme	due	534:536	arg1	Chitosan					496:503	Chitosan	496:503	Chitosan	496:503	Chitosan was used as a control sample due to its strong interaction with mucin primarily through electrostatic forces.
32623331	3	12	theme	due	534:536	arg1	sample					527:532	a control sample	517:532	a control sample due to its strong interaction with mucin primarily through electrostatic forces	517:612	Chitosan was used as a control sample due to its strong interaction with mucin primarily through electrostatic forces.
32623331	5	13	theme	polymers	909:916	arg1	charge					895:900	the charge	891:900	the charge of the polymers	891:916	Both the charge of the polymers and the type of amine groups had a pronounced effect on the interactions.
32623331	5	13	theme	polymers	909:916	arg1	type					926:929	the type	922:929	the type of amine groups	922:945	Both the charge of the polymers and the type of amine groups had a pronounced effect on the interactions.
32623331	2	14	theme	groups	469:474	arg1	role					446:449	the role	442:449	the role of the functional groups	442:474	Since the molecular weight of the polymers and the degree of modification were identical for each derivative, the role of the functional groups could be evaluated.
32623331	5	15	theme	amine	934:938	arg1	groups					940:945	amine groups	934:945	amine groups	934:945	Both the charge of the polymers and the type of amine groups had a pronounced effect on the interactions.
32623331	7	16	dep	in	1165:1166	arg1	vitro					1168:1172	vitro	1168:1172	vitro	1168:1172	The results obtained allow us to classify these polymers in terms of in vitro mucoadhesive strength, which can be useful in the design of mucoadhesive formulations.
32623331	4	17	theme	turbidimetric	803:815	arg1	titration					817:825	turbidimetric titration	803:825	turbidimetric titration	803:825	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	2	18	theme	functional	458:467	arg1	groups					469:474	the functional groups	454:474	the functional groups	454:474	Since the molecular weight of the polymers and the degree of modification were identical for each derivative, the role of the functional groups could be evaluated.
32623331	1	19	with	polyaspartamides	124:139	arg1	groups					170:175	various functional side groups	146:175	various functional side groups including primary, secondary, tertiary amine or carboxyl groups	146:239	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	1	19	with	polyaspartamides	124:139	arg1	amine					216:220	primary, secondary, tertiary amine	187:220	primary, secondary, tertiary amine	187:220	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	1	19	with	polyaspartamides	124:139	arg1	groups					234:239	carboxyl groups	225:239	carboxyl groups	225:239	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	2	20	theme	molecular	342:350	arg1	identical					411:419	identical	411:419	identical	411:419	Since the molecular weight of the polymers and the degree of modification were identical for each derivative, the role of the functional groups could be evaluated.
32623331	2	20	theme	molecular	342:350	arg1	weight					352:357	the molecular weight	338:357	the molecular weight of the polymers	338:373	Since the molecular weight of the polymers and the degree of modification were identical for each derivative, the role of the functional groups could be evaluated.
32623331	4	21	theme	available	701:709	arg1	mucin					727:731	commercially available porcine gastric mucin	688:731	commercially available porcine gastric mucin	688:731	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	0	22	theme	Mucoadhesive	0:11	arg1	interactions					13:24	Mucoadhesive interactions	0:24	Mucoadhesive interactions between synthetic polyaspartamides and porcine gastric mucin on the colloid size scale.	0:112	Mucoadhesive interactions between synthetic polyaspartamides and porcine gastric mucin on the colloid size scale.
32623331	1	23	theme	composition	289:299	arg1	effect					270:275	the effect	266:275	the effect of chemical composition on polymer-mucin interactions	266:329	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	1	24	dep	primary	187:193	arg1	tertiary					207:214	tertiary	207:214	tertiary	207:214	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	1	24	dep	primary	187:193	arg1	secondary					196:204	secondary	196:204	secondary	196:204	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	2	25	theme	modification	393:404	arg1	identical					411:419	identical	411:419	identical	411:419	Since the molecular weight of the polymers and the degree of modification were identical for each derivative, the role of the functional groups could be evaluated.
32623331	2	25	theme	modification	393:404	arg1	weight					352:357	the molecular weight	338:357	the molecular weight of the polymers	338:373	Since the molecular weight of the polymers and the degree of modification were identical for each derivative, the role of the functional groups could be evaluated.
32623331	2	25	theme	modification	393:404	arg1	degree					383:388	the degree	379:388	the degree of modification	379:404	Since the molecular weight of the polymers and the degree of modification were identical for each derivative, the role of the functional groups could be evaluated.
32623331	0	26	theme	synthetic	34:42	arg1	polyaspartamides					44:59	synthetic polyaspartamides	34:59	synthetic polyaspartamides	34:59	Mucoadhesive interactions between synthetic polyaspartamides and porcine gastric mucin on the colloid size scale.
32623331	4	27	theme	potential	862:870	arg1	measurements					872:883	zeta potential measurements	857:883	zeta potential measurements	857:883	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	4	28	theme	various	777:783	arg1	titration					817:825	turbidimetric titration	803:825	turbidimetric titration	803:825	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	4	28	theme	various	777:783	arg1	scattering					842:851	dynamic light scattering	828:851	dynamic light scattering	828:851	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	4	28	theme	various	777:783	arg1	methods					785:791	various methods	777:791	various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements	777:883	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	4	28	theme	various	777:783	arg1	measurements					872:883	zeta potential measurements	857:883	zeta potential measurements	857:883	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	4	29	theme	size	760:763	arg1	scale					765:769	the colloid size scale	748:769	the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements	748:883	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	1	30	theme	polymer-mucin	304:316	arg1	interactions					318:329	polymer-mucin interactions	304:329	polymer-mucin interactions	304:329	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	1	31	theme	Synthetic	114:122	arg1	polyaspartamides					124:139	Synthetic polyaspartamides	114:139	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups	114:239	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	7	32	theme	mucoadhesive	1174:1185	arg1	strength					1187:1194	in vitro mucoadhesive strength	1165:1194	in vitro mucoadhesive strength	1165:1194	The results obtained allow us to classify these polymers in terms of in vitro mucoadhesive strength, which can be useful in the design of mucoadhesive formulations.
32623331	3	33	theme	control	519:525	arg1	Chitosan					496:503	Chitosan	496:503	Chitosan	496:503	Chitosan was used as a control sample due to its strong interaction with mucin primarily through electrostatic forces.
32623331	3	33	theme	control	519:525	arg1	sample					527:532	a control sample	517:532	a control sample due to its strong interaction with mucin primarily through electrostatic forces	517:612	Chitosan was used as a control sample due to its strong interaction with mucin primarily through electrostatic forces.
32623331	4	34	theme	aqueous	666:672	arg1	dispersion					674:683	the aqueous dispersion	662:683	the aqueous dispersion of commercially available porcine gastric mucin	662:731	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	4	35	theme	zeta	857:860	arg1	measurements					872:883	zeta potential measurements	857:883	zeta potential measurements	857:883	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	1	36	theme	carboxyl	225:232	arg1	groups					234:239	carboxyl groups	225:239	carboxyl groups	225:239	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	4	37	theme	gastric	719:725	arg1	mucin					727:731	commercially available porcine gastric mucin	688:731	commercially available porcine gastric mucin	688:731	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	1	38	from	effect	270:275	arg1	interactions					318:329	polymer-mucin interactions	304:329	polymer-mucin interactions	304:329	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	7	39	theme	strength	1187:1194	arg1	terms					1156:1160	terms	1156:1160	terms of in vitro mucoadhesive strength, which can be useful in the design of mucoadhesive formulations	1156:1258	The results obtained allow us to classify these polymers in terms of in vitro mucoadhesive strength, which can be useful in the design of mucoadhesive formulations.
32623331	6	40	theme	sodium	1071:1076	arg1	chloride					1078:1085	sodium chloride	1071:1085	sodium chloride	1071:1085	The interactions were further analysed by partially screening them with either sodium chloride or urea.
32623331	0	41	theme	gastric	73:79	arg1	mucin					81:85	porcine gastric mucin	65:85	porcine gastric mucin	65:85	Mucoadhesive interactions between synthetic polyaspartamides and porcine gastric mucin on the colloid size scale.
32623331	3	42	used	used	509:512	arg2	sample					527:532	a control sample	517:532	a control sample due to its strong interaction with mucin primarily through electrostatic forces	517:612	Chitosan was used as a control sample due to its strong interaction with mucin primarily through electrostatic forces.
32623331	3	42	used	used	509:512	arg2	Chitosan					496:503	Chitosan	496:503	Chitosan	496:503	Chitosan was used as a control sample due to its strong interaction with mucin primarily through electrostatic forces.
32623331	2	43	theme	polymers	366:373	arg1	identical					411:419	identical	411:419	identical	411:419	Since the molecular weight of the polymers and the degree of modification were identical for each derivative, the role of the functional groups could be evaluated.
32623331	2	43	theme	polymers	366:373	arg1	weight					352:357	the molecular weight	338:357	the molecular weight of the polymers	338:373	Since the molecular weight of the polymers and the degree of modification were identical for each derivative, the role of the functional groups could be evaluated.
32623331	2	43	theme	polymers	366:373	arg1	degree					383:388	the degree	379:388	the degree of modification	379:404	Since the molecular weight of the polymers and the degree of modification were identical for each derivative, the role of the functional groups could be evaluated.
32623331	0	44	theme	porcine	65:71	arg1	mucin					81:85	porcine gastric mucin	65:85	porcine gastric mucin	65:85	Mucoadhesive interactions between synthetic polyaspartamides and porcine gastric mucin on the colloid size scale.
32623331	7	45	from	design	1224:1229	arg1	useful					1210:1215	useful	1210:1215	useful	1210:1215	The results obtained allow us to classify these polymers in terms of in vitro mucoadhesive strength, which can be useful in the design of mucoadhesive formulations.
32623331	3	46	theme	electrostatic	593:605	arg1	forces					607:612	electrostatic forces	593:612	electrostatic forces	593:612	Chitosan was used as a control sample due to its strong interaction with mucin primarily through electrostatic forces.
32623331	5	47	contain	had	947:949	arg2	effect					964:969	a pronounced effect	951:969	a pronounced effect	951:969	Both the charge of the polymers and the type of amine groups had a pronounced effect on the interactions.
32623331	5	47	contain	had	947:949	arg1	charge					895:900	the charge	891:900	the charge of the polymers	891:916	Both the charge of the polymers and the type of amine groups had a pronounced effect on the interactions.
32623331	5	47	contain	had	947:949	arg1	type					926:929	the type	922:929	the type of amine groups	922:945	Both the charge of the polymers and the type of amine groups had a pronounced effect on the interactions.
32623331	7	48	theme	in	1165:1166	arg1	strength					1187:1194	in vitro mucoadhesive strength	1165:1194	in vitro mucoadhesive strength	1165:1194	The results obtained allow us to classify these polymers in terms of in vitro mucoadhesive strength, which can be useful in the design of mucoadhesive formulations.
32623331	4	49	theme	dynamic	828:834	arg1	scattering					842:851	dynamic light scattering	828:851	dynamic light scattering	828:851	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	4	50	theme	porcine	711:717	arg1	mucin					727:731	commercially available porcine gastric mucin	688:731	commercially available porcine gastric mucin	688:731	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	1	51	theme	various	146:152	arg1	groups					170:175	various functional side groups	146:175	various functional side groups including primary, secondary, tertiary amine or carboxyl groups	146:239	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	1	51	theme	various	146:152	arg1	amine					216:220	primary, secondary, tertiary amine	187:220	primary, secondary, tertiary amine	187:220	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	1	51	theme	various	146:152	arg1	groups					234:239	carboxyl groups	225:239	carboxyl groups	225:239	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	1	52	theme	functional	154:163	arg1	groups					170:175	various functional side groups	146:175	various functional side groups including primary, secondary, tertiary amine or carboxyl groups	146:239	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	1	52	theme	functional	154:163	arg1	amine					216:220	primary, secondary, tertiary amine	187:220	primary, secondary, tertiary amine	187:220	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	1	52	theme	functional	154:163	arg1	groups					234:239	carboxyl groups	225:239	carboxyl groups	225:239	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	4	53	theme	colloid	752:758	arg1	scale					765:769	the colloid size scale	748:769	the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements	748:883	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	7	54	theme	mucoadhesive	1234:1245	arg1	formulations					1247:1258	mucoadhesive formulations	1234:1258	mucoadhesive formulations	1234:1258	The results obtained allow us to classify these polymers in terms of in vitro mucoadhesive strength, which can be useful in the design of mucoadhesive formulations.
32623331	1	55	theme	side	165:168	arg1	groups					170:175	various functional side groups	146:175	various functional side groups including primary, secondary, tertiary amine or carboxyl groups	146:239	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	1	55	theme	side	165:168	arg1	amine					216:220	primary, secondary, tertiary amine	187:220	primary, secondary, tertiary amine	187:220	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	1	55	theme	side	165:168	arg1	groups					234:239	carboxyl groups	225:239	carboxyl groups	225:239	Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl groups were designed to explore the effect of chemical composition on polymer-mucin interactions.
32623331	7	56	theme	formulations	1247:1258	arg1	design					1224:1229	the design	1220:1229	the design of mucoadhesive formulations	1220:1258	The results obtained allow us to classify these polymers in terms of in vitro mucoadhesive strength, which can be useful in the design of mucoadhesive formulations.
32623331	4	57	theme	light	836:840	arg1	scattering					842:851	dynamic light scattering	828:851	dynamic light scattering	828:851	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	4	58	theme	Mucoadhesive	615:626	arg1	interactions					628:639	Mucoadhesive interactions	615:639	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin	615:731	Mucoadhesive interactions of the polymers with the aqueous dispersion of commercially available porcine gastric mucin were probed on the colloid size scale using various methods including turbidimetric titration, dynamic light scattering and zeta potential measurements.
32623331	3	59	with	interaction	552:562	arg1	mucin					569:573	mucin	569:573	mucin	569:573	Chitosan was used as a control sample due to its strong interaction with mucin primarily through electrostatic forces.
32004602	2	0	theme	wound	499:503	arg1	healing					505:511	the wound healing	495:511	the wound healing of diabetic mice	495:528	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	3	1	theme	fibers	671:676	arg1	concentration					642:654	the most suitable concentration	624:654	the most suitable concentration of stabilizing fibers	624:676	It was found the critical concentration of CA was between 15% and 25% (w/v), and the most suitable concentration of stabilizing fibers was 22.5%.
32004602	3	1	theme	fibers	671:676	arg1	%					686:686	22.5%	682:686	22.5%	682:686	It was found the critical concentration of CA was between 15% and 25% (w/v), and the most suitable concentration of stabilizing fibers was 22.5%.
32004602	4	2	theme	infiltration	819:830	arg1	speed					832:836	low infiltration speed	815:836	low infiltration speed	815:836	When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water.
32004602	6	3	from	development	1297:1307	arg1	future					1339:1344	future	1339:1344	future	1339:1344	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	1	4	theme	nanofiber	160:168	arg1	membranes					170:178	nanofiber membranes	160:178	nanofiber membranes prepared from electrospinning	160:208	Recently, the function of nanofiber membranes prepared from electrospinning in accelerating wound healing has attracted wide attention.
32004602	6	5	theme	application	1213:1223	arg1	range					1225:1229	the application range	1209:1229	the application range of sesamol, CA and zein	1209:1253	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	4	6	from	speed	832:836	arg1	water					860:864	water	860:864	water	860:864	When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water.
32004602	6	7	from	design	1286:1291	arg1	future					1339:1344	future	1339:1344	future	1339:1344	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	4	8	theme	low	815:817	arg1	speed					832:836	low infiltration speed	815:836	low infiltration speed	815:836	When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water.
32004602	1	9	theme	membranes	170:178	arg1	function					148:155	the function	144:155	the function of nanofiber membranes prepared from electrospinning in accelerating wound healing	144:238	Recently, the function of nanofiber membranes prepared from electrospinning in accelerating wound healing has attracted wide attention.
32004602	5	10	theme	diabetic	1163:1170	arg1	mice					1172:1175	diabetic mice	1163:1175	diabetic mice	1163:1175	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	0	11	theme	diabetic	110:117	arg1	healing					125:131	diabetic wound healing	110:131	diabetic wound healing	110:131	Sesamol incorporated cellulose acetate-zein composite nanofiber membrane: An efficient strategy to accelerate diabetic wound healing.
32004602	5	12	theme	chronic	1099:1105	arg1	inflammation					1107:1118	chronic inflammation	1099:1118	chronic inflammation in wounds	1099:1128	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	5	13	from	inflammation	1107:1118	arg1	wounds					1123:1128	wounds	1123:1128	wounds	1123:1128	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	4	14	theme	CA/zein	698:704	arg1	ratio					706:710	the CA/zein ratio	694:710	the CA/zein ratio	694:710	When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water.
32004602	5	15	from	healing	1152:1158	arg1	mice					1172:1175	diabetic mice	1163:1175	diabetic mice	1163:1175	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	2	16	theme	mice	525:528	arg1	healing					505:511	the wound healing	495:511	the wound healing of diabetic mice	495:528	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	4	17	from	structure	804:812	arg1	water					860:864	water	860:864	water	860:864	When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water.
32004602	4	18	theme	intermolecular	789:802	arg1	structure					804:812	stable intermolecular structure	782:812	stable intermolecular structure	782:812	When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water.
32004602	2	19	theme	nanofiber	291:299	arg1	membranes					301:309	novel nanofiber membranes	285:309	novel nanofiber membranes consisted of cellulose acetate (CA) and zein	285:354	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	6	20	theme	CA	1243:1244	arg1	range					1225:1229	the application range	1209:1229	the application range of sesamol, CA and zein	1209:1253	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	6	21	theme	wound	1316:1320	arg1	dressings					1322:1330	new wound dressings	1312:1330	new wound dressings in the future	1312:1344	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	0	22	theme	wound	119:123	arg1	healing					125:131	diabetic wound healing	110:131	diabetic wound healing	110:131	Sesamol incorporated cellulose acetate-zein composite nanofiber membrane: An efficient strategy to accelerate diabetic wound healing.
32004602	4	23	theme	stable	782:787	arg1	structure					804:812	stable intermolecular structure	782:812	stable intermolecular structure	782:812	When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water.
32004602	2	24	theme	novel	285:289	arg1	membranes					301:309	novel nanofiber membranes	285:309	novel nanofiber membranes consisted of cellulose acetate (CA) and zein	285:354	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	6	25	from	dressings	1322:1330	arg1	future					1339:1344	future	1339:1344	future	1339:1344	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	2	26	theme	sesamol-loaded	447:460	arg1	membranes					482:490	sesamol-loaded composite nanofiber membranes	447:490	sesamol-loaded composite nanofiber membranes	447:490	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	5	27	theme	keratinocyte	1065:1076	arg1	growth					1078:1083	keratinocyte growth	1065:1083	keratinocyte growth	1065:1083	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	4	28	theme	high	842:845	arg1	stability					847:855	high stability	842:855	high stability	842:855	When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water.
32004602	2	29	theme	delivery	393:400	arg1	vehicles					402:409	efficient delivery vehicles	383:409	efficient delivery vehicles for sesamol	383:421	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	2	30	theme	efficient	383:391	arg1	vehicles					402:409	efficient delivery vehicles	383:409	efficient delivery vehicles for sesamol	383:421	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	0	31	theme	acetate-zein	31:42	arg1	membrane					64:71	cellulose acetate-zein composite nanofiber membrane	21:71	cellulose acetate-zein composite nanofiber membrane	21:71	Sesamol incorporated cellulose acetate-zein composite nanofiber membrane: An efficient strategy to accelerate diabetic wound healing.
32004602	2	32	theme	cellulose	324:332	arg1	CA					343:344	CA	343:344	CA	343:344	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	2	32	theme	cellulose	324:332	arg1	acetate					334:340	cellulose acetate	324:340	cellulose acetate (CA)	324:345	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	0	33	theme	cellulose	21:29	arg1	membrane					64:71	cellulose acetate-zein composite nanofiber membrane	21:71	cellulose acetate-zein composite nanofiber membrane	21:71	Sesamol incorporated cellulose acetate-zein composite nanofiber membrane: An efficient strategy to accelerate diabetic wound healing.
32004602	5	34	theme	wound	1146:1150	arg1	healing					1152:1158	wound healing	1146:1158	wound healing in diabetic mice	1146:1175	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	5	35	theme	TGF-β	1014:1018	arg1	transduction					1038:1049	TGF-β signaling pathway transduction	1014:1049	TGF-β signaling pathway transduction	1014:1049	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	3	36	theme	critical	560:567	arg1	concentration					569:581	the critical concentration	556:581	the critical concentration of CA	556:587	It was found the critical concentration of CA was between 15% and 25% (w/v), and the most suitable concentration of stabilizing fibers was 22.5%.
32004602	1	37	theme	wound	226:230	arg1	healing					232:238	wound healing	226:238	wound healing	226:238	Recently, the function of nanofiber membranes prepared from electrospinning in accelerating wound healing has attracted wide attention.
32004602	0	38	theme	nanofiber	54:62	arg1	membrane					64:71	cellulose acetate-zein composite nanofiber membrane	21:71	cellulose acetate-zein composite nanofiber membrane	21:71	Sesamol incorporated cellulose acetate-zein composite nanofiber membrane: An efficient strategy to accelerate diabetic wound healing.
32004602	6	39	dep	design	1286:1291	arg1	the					1282:1284	the	1282:1284	the	1282:1284	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	5	40	theme	signaling	1020:1028	arg1	transduction					1038:1049	TGF-β signaling pathway transduction	1014:1049	TGF-β signaling pathway transduction	1014:1049	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	4	41	theme	uniform	760:766	arg1	distribution					768:779	uniform distribution	760:779	uniform distribution	760:779	When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water.
32004602	0	42	theme	composite	44:52	arg1	membrane					64:71	cellulose acetate-zein composite nanofiber membrane	21:71	cellulose acetate-zein composite nanofiber membrane	21:71	Sesamol incorporated cellulose acetate-zein composite nanofiber membrane: An efficient strategy to accelerate diabetic wound healing.
32004602	2	43	theme	membranes	482:490	arg1	effect					437:442	then the effect	428:442	then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice	428:528	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	5	44	theme	pathway	1030:1036	arg1	transduction					1038:1049	TGF-β signaling pathway transduction	1014:1049	TGF-β signaling pathway transduction	1014:1049	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	5	45	with	membrane	891:898	arg1	sesamol					915:921	high-dose sesamol	905:921	high-dose sesamol (5% of total polymer concentration, w/w)	905:962	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	2	46	theme	diabetic	516:523	arg1	mice					525:528	diabetic mice	516:528	diabetic mice	516:528	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	2	47	theme	nanofiber	472:480	arg1	membranes					482:490	sesamol-loaded composite nanofiber membranes	447:490	sesamol-loaded composite nanofiber membranes	447:490	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	3	48	theme	CA	586:587	arg1	concentration					569:581	the critical concentration	556:581	the critical concentration of CA	556:587	It was found the critical concentration of CA was between 15% and 25% (w/v), and the most suitable concentration of stabilizing fibers was 22.5%.
32004602	4	49	from	distribution	768:779	arg1	water					860:864	water	860:864	water	860:864	When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water.
32004602	2	50	theme	composite	462:470	arg1	membranes					482:490	sesamol-loaded composite nanofiber membranes	447:490	sesamol-loaded composite nanofiber membranes	447:490	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	3	51	theme	stabilizing	659:669	arg1	fibers					671:676	stabilizing fibers	659:676	stabilizing fibers	659:676	It was found the critical concentration of CA was between 15% and 25% (w/v), and the most suitable concentration of stabilizing fibers was 22.5%.
32004602	6	52	from	future	1339:1344	arg1	development					1297:1307	development	1297:1307	development	1297:1307	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	6	52	from	future	1339:1344	arg1	design					1286:1291	design	1286:1291	design	1286:1291	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	5	53	theme	myofibroblasts	986:999	arg1	formation					973:981	formation	973:981	formation of myofibroblasts	973:999	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	6	54	theme	sesamol	1234:1240	arg1	range					1225:1229	the application range	1209:1229	the application range of sesamol, CA and zein	1209:1253	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	6	55	theme	zein	1250:1253	arg1	range					1225:1229	the application range	1209:1229	the application range of sesamol, CA and zein	1209:1253	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	3	56	theme	suitable	633:640	arg1	concentration					642:654	the most suitable concentration	624:654	the most suitable concentration of stabilizing fibers	624:676	It was found the critical concentration of CA was between 15% and 25% (w/v), and the most suitable concentration of stabilizing fibers was 22.5%.
32004602	3	56	theme	suitable	633:640	arg1	%					686:686	22.5%	682:686	22.5%	682:686	It was found the critical concentration of CA was between 15% and 25% (w/v), and the most suitable concentration of stabilizing fibers was 22.5%.
32004602	5	57	theme	total	930:934	arg1	concentration					944:956	total polymer concentration	930:956	total polymer concentration	930:956	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	5	58	theme	composite	871:879	arg1	membrane					891:898	The composite nanofiber membrane	867:898	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w)	867:962	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	5	59	theme	high-dose	905:913	arg1	sesamol					915:921	high-dose sesamol	905:921	high-dose sesamol (5% of total polymer concentration, w/w)	905:962	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	6	60	theme	new	1312:1314	arg1	dressings					1322:1330	new wound dressings	1312:1330	new wound dressings in the future	1312:1344	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	4	61	from	stability	847:855	arg1	water					860:864	water	860:864	water	860:864	When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water.
32004602	5	62	theme	polymer	936:942	arg1	concentration					944:956	total polymer concentration	930:956	total polymer concentration	930:956	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	4	63	from	diameter	747:754	arg1	water					860:864	water	860:864	water	860:864	When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water.
32004602	5	64	theme	nanofiber	881:889	arg1	membrane					891:898	The composite nanofiber membrane	867:898	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w)	867:962	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	1	65	theme	wide	254:257	arg1	attention					259:267	wide attention	254:267	wide attention	254:267	Recently, the function of nanofiber membranes prepared from electrospinning in accelerating wound healing has attracted wide attention.
32004602	0	66	theme	efficient	77:85	arg1	strategy					87:94	An efficient strategy	74:94	An efficient strategy to accelerate diabetic wound healing	74:131	Sesamol incorporated cellulose acetate-zein composite nanofiber membrane: An efficient strategy to accelerate diabetic wound healing.
32004602	5	67	theme	concentration	944:956	arg1	concentration					944:956	total polymer concentration	930:956	total polymer concentration	930:956	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	5	67	theme	concentration	944:956	arg1	%					925:925	5%	924:925	5% of total polymer concentration	924:956	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	5	67	theme	concentration	944:956	arg1	w/w					959:961	w/w	959:961	w/w	959:961	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	6	68	theme	dressings	1322:1330	arg1	development					1297:1307	development	1297:1307	development	1297:1307	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	6	68	theme	dressings	1322:1330	arg1	design					1286:1291	design	1286:1291	design	1286:1291	This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
32004602	2	69	from	effect	437:442	arg1	healing					505:511	the wound healing	495:511	the wound healing of diabetic mice	495:528	In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied.
32004602	4	70	theme	small	741:745	arg1	diameter					747:754	small diameter	741:754	small diameter	741:754	When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water.
32004602	5	71	dep	sesamol	915:921	arg1	concentration					944:956	total polymer concentration	930:956	total polymer concentration	930:956	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	5	71	dep	sesamol	915:921	arg1	%					925:925	5%	924:925	5% of total polymer concentration	924:956	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
32004602	5	71	dep	sesamol	915:921	arg1	w/w					959:961	w/w	959:961	w/w	959:961	The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-β signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice.
33789194	0	0	theme	phosphorylated	97:110	arg1	peptides					112:119	phosphorylated peptides	97:119	phosphorylated peptides	97:119	Post-synthesis of biomimetic chitosan with honeycomb-like structure for sensitive recognition of phosphorylated peptides.
33789194	4	1	theme	@	611:611	arg1	AMPA-Ti4+					612:620	CTSM@AMPA-Ti4+	607:620	CTSM@AMPA-Ti4+	607:620	CTSM@AMPA-Ti4+ showed extremely high sensitivity (0.4 fmol) and selectivity at a low composition molar ratio of β-casein/BSA (1:1000).
33789194	2	2	theme	Ti	405:406	arg1	cation					413:418	Ti (IV) cation	405:418	Ti (IV) cation	405:418	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	4	3	theme	CTSM	607:610	arg1	AMPA-Ti4+					612:620	CTSM@AMPA-Ti4+	607:620	CTSM@AMPA-Ti4+	607:620	CTSM@AMPA-Ti4+ showed extremely high sensitivity (0.4 fmol) and selectivity at a low composition molar ratio of β-casein/BSA (1:1000).
33789194	0	4	theme	peptides	112:119	arg1	recognition					82:92	sensitive recognition	72:92	sensitive recognition of phosphorylated peptides	72:119	Post-synthesis of biomimetic chitosan with honeycomb-like structure for sensitive recognition of phosphorylated peptides.
33789194	7	5	theme	phosphoproteome	1093:1107	arg1	analysis					1109:1116	phosphoproteome analysis	1093:1116	phosphoproteome analysis	1093:1116	This study offers a way about diversiform functionalization of CTSM in phosphoproteome analysis and disease research.
33789194	3	6	theme	high	512:515	arg1	amount					530:535	high Ti4+ loading amount	512:535	high Ti4+ loading amount	512:535	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	5	7	theme	acid/base	890:898	arg1	solution					900:907	the acid/base solution	886:907	the acid/base solution	886:907	What's more, it can keep its performance in the case that used to capture phosphorylated peptides from standard protein ten times or soaking in the acid/base solution for a long time.
33789194	5	8	from	soaking	875:881	arg1	solution					900:907	the acid/base solution	886:907	the acid/base solution	886:907	What's more, it can keep its performance in the case that used to capture phosphorylated peptides from standard protein ten times or soaking in the acid/base solution for a long time.
33789194	2	9	theme	adsorbent	313:321	arg1	chromatography					291:304	a biomimetic honeycombed affinity chromatography	257:304	a biomimetic honeycombed affinity chromatography (IMAC) adsorbent	257:321	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	2	9	theme	adsorbent	313:321	arg1	IMAC					307:310	IMAC	307:310	IMAC	307:310	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	1	10	theme	phosphorylated	203:216	arg1	peptides					218:225	phosphorylated peptides	203:225	phosphorylated peptides	203:225	Chemical modification of biological materials is indispensable for enrichment of phosphorylated peptides.
33789194	7	11	theme	disease	1122:1128	arg1	research					1130:1137	disease research	1122:1137	disease research	1122:1137	This study offers a way about diversiform functionalization of CTSM in phosphoproteome analysis and disease research.
33789194	3	12	theme	AMPA-Ti4+	442:450	arg1	adsorbent					562:570	adsorbent	562:570	adsorbent	562:570	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	3	12	theme	AMPA-Ti4+	442:450	arg1	composites					452:461	The as-prepared CTSM@AMPA-Ti4+ composites	421:461	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount	421:535	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	3	13	with	composites	452:461	arg1	structure					475:483	stable structure	468:483	stable structure	468:483	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	3	13	with	composites	452:461	arg1	hindrance					497:505	low steric hindrance	486:505	low steric hindrance	486:505	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	3	13	with	composites	452:461	arg1	amount					530:535	high Ti4+ loading amount	512:535	high Ti4+ loading amount	512:535	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	1	14	theme	peptides	218:225	arg1	enrichment					189:198	enrichment	189:198	enrichment of phosphorylated peptides	189:225	Chemical modification of biological materials is indispensable for enrichment of phosphorylated peptides.
33789194	7	15	theme	diversiform	1052:1062	arg1	functionalization					1064:1080	diversiform functionalization	1052:1080	diversiform functionalization of CTSM in phosphoproteome analysis and disease research	1052:1137	This study offers a way about diversiform functionalization of CTSM in phosphoproteome analysis and disease research.
33789194	6	16	from	saliva	1014:1019	arg1	peptides					994:1001	35 phosphorylated peptides	976:1001	35 phosphorylated peptides from human saliva	976:1019	In addition, CTSM@AMPA-Ti4+ successfully captured 35 phosphorylated peptides from human saliva.
33789194	2	17	theme	chelating	358:366	arg1	Chitosan					348:355	Crosslinked Chitosan	336:355	Crosslinked Chitosan	336:355	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	2	17	theme	chelating	358:366	arg1	phosphate					380:388	chelating aminomethyl phosphate	358:388	chelating aminomethyl phosphate decorated with Ti (IV) cation	358:418	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	4	18	theme	low	688:690	arg1	ratio					710:714	a low composition molar ratio	686:714	a low composition molar ratio of β-casein/BSA (1:1000)	686:739	CTSM@AMPA-Ti4+ showed extremely high sensitivity (0.4 fmol) and selectivity at a low composition molar ratio of β-casein/BSA (1:1000).
33789194	3	19	theme	as-prepared	425:435	arg1	adsorbent					562:570	adsorbent	562:570	adsorbent	562:570	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	3	19	theme	as-prepared	425:435	arg1	composites					452:461	The as-prepared CTSM@AMPA-Ti4+ composites	421:461	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount	421:535	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	6	20	theme	@	943:943	arg1	AMPA-Ti4+					944:952	CTSM@AMPA-Ti4+	939:952	CTSM@AMPA-Ti4+	939:952	In addition, CTSM@AMPA-Ti4+ successfully captured 35 phosphorylated peptides from human saliva.
33789194	3	21	theme	stable	468:473	arg1	structure					475:483	stable structure	468:483	stable structure	468:483	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	0	22	theme	chitosan	29:36	arg1	Post-synthesis					0:13	Post-synthesis	0:13	Post-synthesis of biomimetic chitosan with honeycomb-like structure for sensitive recognition of phosphorylated peptides.	0:120	Post-synthesis of biomimetic chitosan with honeycomb-like structure for sensitive recognition of phosphorylated peptides.
33789194	6	23	theme	CTSM	939:942	arg1	AMPA-Ti4+					944:952	CTSM@AMPA-Ti4+	939:952	CTSM@AMPA-Ti4+	939:952	In addition, CTSM@AMPA-Ti4+ successfully captured 35 phosphorylated peptides from human saliva.
33789194	3	24	theme	phosphopeptides	590:604	arg1	enrichment					576:585	enrichment	576:585	enrichment of phosphopeptides	576:604	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	1	25	theme	Chemical	122:129	arg1	modification					131:142	Chemical modification	122:142	Chemical modification of biological materials	122:166	Chemical modification of biological materials is indispensable for enrichment of phosphorylated peptides.
33789194	5	26	from	solution	900:907	arg1	soaking					875:881	soaking	875:881	soaking	875:881	What's more, it can keep its performance in the case that used to capture phosphorylated peptides from standard protein ten times or soaking in the acid/base solution for a long time.
33789194	0	27	theme	biomimetic	18:27	arg1	chitosan					29:36	biomimetic chitosan	18:36	biomimetic chitosan	18:36	Post-synthesis of biomimetic chitosan with honeycomb-like structure for sensitive recognition of phosphorylated peptides.
33789194	6	28	theme	phosphorylated	979:992	arg1	peptides					994:1001	35 phosphorylated peptides	976:1001	35 phosphorylated peptides from human saliva	976:1019	In addition, CTSM@AMPA-Ti4+ successfully captured 35 phosphorylated peptides from human saliva.
33789194	2	29	theme	Crosslinked	336:346	arg1	Chitosan					348:355	Crosslinked Chitosan	336:355	Crosslinked Chitosan	336:355	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	2	29	theme	Crosslinked	336:346	arg1	phosphate					380:388	chelating aminomethyl phosphate	358:388	chelating aminomethyl phosphate decorated with Ti (IV) cation	358:418	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	5	30	theme	phosphorylated	816:829	arg1	peptides					831:838	phosphorylated peptides	816:838	phosphorylated peptides	816:838	What's more, it can keep its performance in the case that used to capture phosphorylated peptides from standard protein ten times or soaking in the acid/base solution for a long time.
33789194	0	31	theme	honeycomb-like	43:56	arg1	structure					58:66	honeycomb-like structure	43:66	honeycomb-like structure for sensitive recognition of phosphorylated peptides	43:119	Post-synthesis of biomimetic chitosan with honeycomb-like structure for sensitive recognition of phosphorylated peptides.
33789194	3	32	theme	loading	522:528	arg1	amount					530:535	high Ti4+ loading amount	512:535	high Ti4+ loading amount	512:535	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	2	33	theme	honeycombed	270:280	arg1	chromatography					291:304	a biomimetic honeycombed affinity chromatography	257:304	a biomimetic honeycombed affinity chromatography (IMAC) adsorbent	257:321	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	2	33	theme	honeycombed	270:280	arg1	IMAC					307:310	IMAC	307:310	IMAC	307:310	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	3	34	theme	low	486:488	arg1	hindrance					497:505	low steric hindrance	486:505	low steric hindrance	486:505	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	6	35	theme	human	1008:1012	arg1	saliva					1014:1019	human saliva	1008:1019	human saliva	1008:1019	In addition, CTSM@AMPA-Ti4+ successfully captured 35 phosphorylated peptides from human saliva.
33789194	2	36	theme	biomimetic	259:268	arg1	chromatography					291:304	a biomimetic honeycombed affinity chromatography	257:304	a biomimetic honeycombed affinity chromatography (IMAC) adsorbent	257:321	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	2	36	theme	biomimetic	259:268	arg1	IMAC					307:310	IMAC	307:310	IMAC	307:310	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	3	37	theme	steric	490:495	arg1	hindrance					497:505	low steric hindrance	486:505	low steric hindrance	486:505	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	3	38	theme	CTSM	437:440	arg1	adsorbent					562:570	adsorbent	562:570	adsorbent	562:570	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	3	38	theme	CTSM	437:440	arg1	composites					452:461	The as-prepared CTSM@AMPA-Ti4+ composites	421:461	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount	421:535	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	2	39	link	Crosslinked	336:346	arg1	Chitosan					348:355	Crosslinked Chitosan	336:355	Crosslinked Chitosan	336:355	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	2	39	link	Crosslinked	336:346	arg1	phosphate					380:388	chelating aminomethyl phosphate	358:388	chelating aminomethyl phosphate decorated with Ti (IV) cation	358:418	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	7	40	from	functionalization	1064:1080	arg1	analysis					1109:1116	phosphoproteome analysis	1093:1116	phosphoproteome analysis	1093:1116	This study offers a way about diversiform functionalization of CTSM in phosphoproteome analysis and disease research.
33789194	7	40	from	functionalization	1064:1080	arg1	research					1130:1137	disease research	1122:1137	disease research	1122:1137	This study offers a way about diversiform functionalization of CTSM in phosphoproteome analysis and disease research.
33789194	5	41	dep	standard	845:852	arg1	times					866:870	protein ten times	854:870	protein ten times	854:870	What's more, it can keep its performance in the case that used to capture phosphorylated peptides from standard protein ten times or soaking in the acid/base solution for a long time.
33789194	3	42	theme	Ti4+	517:520	arg1	amount					530:535	high Ti4+ loading amount	512:535	high Ti4+ loading amount	512:535	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	3	43	theme	@	441:441	arg1	adsorbent					562:570	adsorbent	562:570	adsorbent	562:570	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	3	43	theme	@	441:441	arg1	composites					452:461	The as-prepared CTSM@AMPA-Ti4+ composites	421:461	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount	421:535	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	5	44	used	used	800:803	arg2	case					790:793	the case	786:793	the case that used to capture phosphorylated peptides from standard protein ten times or soaking in the acid/base solution for a long time	786:923	What's more, it can keep its performance in the case that used to capture phosphorylated peptides from standard protein ten times or soaking in the acid/base solution for a long time.
33789194	7	45	theme	CTSM	1085:1088	arg1	functionalization					1064:1080	diversiform functionalization	1052:1080	diversiform functionalization of CTSM in phosphoproteome analysis and disease research	1052:1137	This study offers a way about diversiform functionalization of CTSM in phosphoproteome analysis and disease research.
33789194	1	46	theme	biological	147:156	arg1	materials					158:166	biological materials	147:166	biological materials	147:166	Chemical modification of biological materials is indispensable for enrichment of phosphorylated peptides.
33789194	3	47	used	used	542:545	arg2	composites					452:461	The as-prepared CTSM@AMPA-Ti4+ composites	421:461	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount	421:535	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	3	47	used	used	542:545	arg2	adsorbent					562:570	adsorbent	562:570	adsorbent	562:570	The as-prepared CTSM@AMPA-Ti4+ composites with stable structure, low steric hindrance, and high Ti4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides.
33789194	5	48	theme	long	915:918	arg1	time					920:923	a long time	913:923	a long time	913:923	What's more, it can keep its performance in the case that used to capture phosphorylated peptides from standard protein ten times or soaking in the acid/base solution for a long time.
33789194	0	49	with	Post-synthesis	0:13	arg1	structure					58:66	honeycomb-like structure	43:66	honeycomb-like structure for sensitive recognition of phosphorylated peptides	43:119	Post-synthesis of biomimetic chitosan with honeycomb-like structure for sensitive recognition of phosphorylated peptides.
33789194	1	50	theme	materials	158:166	arg1	modification					131:142	Chemical modification	122:142	Chemical modification of biological materials	122:166	Chemical modification of biological materials is indispensable for enrichment of phosphorylated peptides.
33789194	4	51	theme	high	639:642	arg1	sensitivity					644:654	extremely high sensitivity	629:654	extremely high sensitivity (0.4 fmol)	629:665	CTSM@AMPA-Ti4+ showed extremely high sensitivity (0.4 fmol) and selectivity at a low composition molar ratio of β-casein/BSA (1:1000).
33789194	4	51	theme	high	639:642	arg1	fmol					661:664	0.4 fmol	657:664	0.4 fmol	657:664	CTSM@AMPA-Ti4+ showed extremely high sensitivity (0.4 fmol) and selectivity at a low composition molar ratio of β-casein/BSA (1:1000).
33789194	2	52	theme	aminomethyl	368:378	arg1	Chitosan					348:355	Crosslinked Chitosan	336:355	Crosslinked Chitosan	336:355	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	2	52	theme	aminomethyl	368:378	arg1	phosphate					380:388	chelating aminomethyl phosphate	358:388	chelating aminomethyl phosphate decorated with Ti (IV) cation	358:418	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	4	53	theme	molar	704:708	arg1	ratio					710:714	a low composition molar ratio	686:714	a low composition molar ratio of β-casein/BSA (1:1000)	686:739	CTSM@AMPA-Ti4+ showed extremely high sensitivity (0.4 fmol) and selectivity at a low composition molar ratio of β-casein/BSA (1:1000).
33789194	5	54	theme	protein	854:860	arg1	times					866:870	protein ten times	854:870	protein ten times	854:870	What's more, it can keep its performance in the case that used to capture phosphorylated peptides from standard protein ten times or soaking in the acid/base solution for a long time.
33789194	0	55	theme	sensitive	72:80	arg1	recognition					82:92	sensitive recognition	72:92	sensitive recognition of phosphorylated peptides	72:119	Post-synthesis of biomimetic chitosan with honeycomb-like structure for sensitive recognition of phosphorylated peptides.
33789194	2	56	theme	affinity	282:289	arg1	chromatography					291:304	a biomimetic honeycombed affinity chromatography	257:304	a biomimetic honeycombed affinity chromatography (IMAC) adsorbent	257:321	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	2	56	theme	affinity	282:289	arg1	IMAC					307:310	IMAC	307:310	IMAC	307:310	In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation.
33789194	4	57	theme	composition	692:702	arg1	ratio					710:714	a low composition molar ratio	686:714	a low composition molar ratio of β-casein/BSA (1:1000)	686:739	CTSM@AMPA-Ti4+ showed extremely high sensitivity (0.4 fmol) and selectivity at a low composition molar ratio of β-casein/BSA (1:1000).
33789194	4	58	theme	β-casein/BSA	719:730	arg1	ratio					710:714	a low composition molar ratio	686:714	a low composition molar ratio of β-casein/BSA (1:1000)	686:739	CTSM@AMPA-Ti4+ showed extremely high sensitivity (0.4 fmol) and selectivity at a low composition molar ratio of β-casein/BSA (1:1000).
32786521	1	0	theme	chronic	353:359	arg1	wounds					361:366	diabetic chronic wounds	344:366	diabetic chronic wounds	344:366	Immunocompromise and impaired angiogenesis of diabetes lead to chronic inflammation when wounds occur, which is the primary reason for the long-term incurable nature of diabetic chronic wounds.
32786521	7	1	theme	hydrogel	1409:1416	arg1	strategy					1542:1549	a safe and effective treatment strategy	1511:1549	a safe and effective treatment strategy for a diabetic chronic wound	1511:1578	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	7	1	theme	hydrogel	1409:1416	arg1	strategy					1418:1425	this facile hydrogel strategy	1397:1425	this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis	1397:1498	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	6	2	dep	MΦ2	1219:1221	arg1	degree					1244:1249	ionic cross-linking degree	1224:1249	ionic cross-linking degree 0.5%	1224:1254	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	7	3	theme	facile	1402:1407	arg1	strategy					1542:1549	a safe and effective treatment strategy	1511:1549	a safe and effective treatment strategy for a diabetic chronic wound	1511:1578	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	7	3	theme	facile	1402:1407	arg1	strategy					1418:1425	this facile hydrogel strategy	1397:1425	this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis	1397:1498	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	7	4	theme	multiple	1432:1439	arg1	mechanisms					1452:1461	multiple modulation mechanisms	1432:1461	multiple modulation mechanisms of immunocompromise and angiogenesis	1432:1498	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	5	5	theme	wound-healing	1090:1102	arg1	transition					1110:1119	the wound-healing phase transition	1086:1119	the wound-healing phase transition from inflammation to proliferation and remodeling	1086:1169	Furthermore, Cu2+ could be released from the hydrogels to further stimulate angiogenesis, thus accelerating the wound-healing phase transition from inflammation to proliferation and remodeling.
32786521	1	6	theme	wounds	361:366	arg1	nature					334:339	the long-term incurable nature	310:339	the long-term incurable nature of diabetic chronic wounds	310:366	Immunocompromise and impaired angiogenesis of diabetes lead to chronic inflammation when wounds occur, which is the primary reason for the long-term incurable nature of diabetic chronic wounds.
32786521	4	7	theme	consistent	861:870	arg1	phenotype					872:880	the consistent phenotype	857:880	the consistent phenotype of loaded MΦ2	857:894	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	6	8	theme	0.5	1251:1253	arg1	%					1254:1254	%	1254:1254	%	1254:1254	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	4	9	from	macrophages	928:938	arg1	bed					959:961	the wound bed	949:961	the wound bed	949:961	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	3	10	theme	unique	716:721	arg1	lyophilization					723:736	unique lyophilization	716:736	unique lyophilization	716:736	MΦ2 are seeded on the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels.
32786521	4	11	theme	loaded	885:890	arg1	MΦ2					892:894	loaded MΦ2	885:894	loaded MΦ2	885:894	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	4	12	theme	wound	836:840	arg1	site					842:845	the wound site	832:845	the wound site	832:845	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	4	13	theme	@	787:787	arg1	hydrogel					792:799	The Cu-HHA/PVA@MΦ2 hydrogel	773:799	The Cu-HHA/PVA@MΦ2 hydrogel	773:799	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	0	14	theme	Immunocompromise	89:104	arg1	Improvement					74:84	Synergistic Improvement	62:84	Synergistic Improvement of Immunocompromise and Impaired Angiogenesis	62:130	Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing.
32786521	3	15	theme	Cu-HHA/PVA	747:756	arg1	hydrogels					762:770	Cu-HHA/PVA@MΦ2 hydrogels	747:770	Cu-HHA/PVA@MΦ2 hydrogels	747:770	MΦ2 are seeded on the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels.
32786521	5	16	from	inflammation	1126:1137	arg1	transition					1110:1119	the wound-healing phase transition	1086:1119	the wound-healing phase transition from inflammation to proliferation and remodeling	1086:1169	Furthermore, Cu2+ could be released from the hydrogels to further stimulate angiogenesis, thus accelerating the wound-healing phase transition from inflammation to proliferation and remodeling.
32786521	0	17	link	Cross-linked	5:16	arg1	Hydrogel					22:29	Dual Cross-linked HHA Hydrogel	0:29	Dual Cross-linked HHA Hydrogel	0:29	Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing.
32786521	4	18	theme	Cu-HHA/PVA	777:786	arg1	hydrogel					792:799	The Cu-HHA/PVA@MΦ2 hydrogel	773:799	The Cu-HHA/PVA@MΦ2 hydrogel	773:799	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	7	19	theme	effective	1522:1530	arg1	strategy					1542:1549	a safe and effective treatment strategy	1511:1549	a safe and effective treatment strategy for a diabetic chronic wound	1511:1578	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	7	19	theme	effective	1522:1530	arg1	strategy					1418:1425	this facile hydrogel strategy	1397:1425	this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis	1397:1498	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	6	20	theme	diabetic	1303:1310	arg1	groups					1312:1317	other diabetic groups	1297:1317	other diabetic groups	1297:1317	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	0	21	theme	Angiogenesis	119:130	arg1	Improvement					74:84	Synergistic Improvement	62:84	Synergistic Improvement of Immunocompromise and Impaired Angiogenesis	62:130	Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing.
32786521	3	22	theme	@	757:757	arg1	hydrogels					762:770	Cu-HHA/PVA@MΦ2 hydrogels	747:770	Cu-HHA/PVA@MΦ2 hydrogels	747:770	MΦ2 are seeded on the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels.
32786521	0	23	theme	Impaired	110:117	arg1	Angiogenesis					119:130	Impaired Angiogenesis	110:130	Impaired Angiogenesis	110:130	Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing.
32786521	1	24	dep	long-term	314:322	arg1	incurable					324:332	incurable	324:332	incurable	324:332	Immunocompromise and impaired angiogenesis of diabetes lead to chronic inflammation when wounds occur, which is the primary reason for the long-term incurable nature of diabetic chronic wounds.
32786521	6	25	theme	cross-linking	1230:1242	arg1	degree					1244:1249	ionic cross-linking degree	1224:1249	ionic cross-linking degree 0.5%	1224:1254	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	4	26	theme	MΦ2	788:790	arg1	hydrogel					792:799	The Cu-HHA/PVA@MΦ2 hydrogel	773:799	The Cu-HHA/PVA@MΦ2 hydrogel	773:799	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	1	27	theme	impaired	196:203	arg1	angiogenesis					205:216	impaired angiogenesis	196:216	impaired angiogenesis	196:216	Immunocompromise and impaired angiogenesis of diabetes lead to chronic inflammation when wounds occur, which is the primary reason for the long-term incurable nature of diabetic chronic wounds.
32786521	0	28	theme	Cross-linked	5:16	arg1	Hydrogel					22:29	Dual Cross-linked HHA Hydrogel	0:29	Dual Cross-linked HHA Hydrogel	0:29	Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing.
32786521	2	29	dep	regulate	459:466	arg1	MΦ2					494:496	MΦ2	494:496	MΦ2	494:496	Herein, a high-molecular-weight hyaluronic acid (HHA) hydrogel is developed to supply and regulate M2 phenotype macrophages (MΦ2) for synergistic improvement of immunocompromise and impaired angiogenesis.
32786521	2	30	theme	synergistic	503:513	arg1	improvement					515:525	synergistic improvement	503:525	synergistic improvement of immunocompromise and impaired angiogenesis	503:571	Herein, a high-molecular-weight hyaluronic acid (HHA) hydrogel is developed to supply and regulate M2 phenotype macrophages (MΦ2) for synergistic improvement of immunocompromise and impaired angiogenesis.
32786521	4	31	theme	MΦ2	892:894	arg1	phenotype					872:880	the consistent phenotype	857:880	the consistent phenotype of loaded MΦ2	857:894	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	2	32	theme	acid	412:415	arg1	hydrogel					423:430	a high-molecular-weight hyaluronic acid (HHA) hydrogel	377:430	a high-molecular-weight hyaluronic acid (HHA) hydrogel	377:430	Herein, a high-molecular-weight hyaluronic acid (HHA) hydrogel is developed to supply and regulate M2 phenotype macrophages (MΦ2) for synergistic improvement of immunocompromise and impaired angiogenesis.
32786521	0	33	theme	Dual	0:3	arg1	Hydrogel					22:29	Dual Cross-linked HHA Hydrogel	0:29	Dual Cross-linked HHA Hydrogel	0:29	Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing.
32786521	1	34	theme	primary	291:297	arg1	which					278:282	which	278:282	which	278:282	Immunocompromise and impaired angiogenesis of diabetes lead to chronic inflammation when wounds occur, which is the primary reason for the long-term incurable nature of diabetic chronic wounds.
32786521	1	34	theme	primary	291:297	arg1	reason					299:304	the primary reason	287:304	the primary reason for the long-term incurable nature of diabetic chronic wounds	287:366	Immunocompromise and impaired angiogenesis of diabetes lead to chronic inflammation when wounds occur, which is the primary reason for the long-term incurable nature of diabetic chronic wounds.
32786521	7	35	theme	modulation	1441:1450	arg1	mechanisms					1452:1461	multiple modulation mechanisms	1432:1461	multiple modulation mechanisms of immunocompromise and angiogenesis	1432:1498	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	7	36	theme	immunocompromise	1466:1481	arg1	mechanisms					1452:1461	multiple modulation mechanisms	1432:1461	multiple modulation mechanisms of immunocompromise and angiogenesis	1432:1498	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	2	37	theme	hyaluronic	401:410	arg1	HHA					418:420	HHA	418:420	HHA	418:420	Herein, a high-molecular-weight hyaluronic acid (HHA) hydrogel is developed to supply and regulate M2 phenotype macrophages (MΦ2) for synergistic improvement of immunocompromise and impaired angiogenesis.
32786521	2	37	theme	hyaluronic	401:410	arg1	acid					412:415	hyaluronic acid	401:415	a high-molecular-weight hyaluronic acid (HHA) hydrogel	377:430	Herein, a high-molecular-weight hyaluronic acid (HHA) hydrogel is developed to supply and regulate M2 phenotype macrophages (MΦ2) for synergistic improvement of immunocompromise and impaired angiogenesis.
32786521	2	38	theme	angiogenesis	560:571	arg1	improvement					515:525	synergistic improvement	503:525	synergistic improvement of immunocompromise and impaired angiogenesis	503:571	Herein, a high-molecular-weight hyaluronic acid (HHA) hydrogel is developed to supply and regulate M2 phenotype macrophages (MΦ2) for synergistic improvement of immunocompromise and impaired angiogenesis.
32786521	6	39	theme	wound	1184:1188	arg1	area					1190:1193	The average wound area	1172:1193	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment	1172:1265	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	6	39	theme	wound	1184:1188	arg1	smaller					1276:1282	smaller	1276:1282	smaller	1276:1282	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	4	40	theme	M1	915:916	arg1	MΦ1					941:943	MΦ1	941:943	MΦ1	941:943	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	4	40	theme	M1	915:916	arg1	macrophages					928:938	the M1 phenotype macrophages	911:938	the M1 phenotype macrophages (MΦ1) in the wound bed	911:961	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	7	41	theme	safe	1513:1516	arg1	strategy					1542:1549	a safe and effective treatment strategy	1511:1549	a safe and effective treatment strategy for a diabetic chronic wound	1511:1578	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	7	41	theme	safe	1513:1516	arg1	strategy					1418:1425	this facile hydrogel strategy	1397:1425	this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis	1397:1498	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	6	42	theme	MΦ2	1219:1221	arg1	treatment					1257:1265	the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment	1201:1265	the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment	1201:1265	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	1	43	theme	diabetes	221:228	arg1	angiogenesis					205:216	impaired angiogenesis	196:216	impaired angiogenesis	196:216	Immunocompromise and impaired angiogenesis of diabetes lead to chronic inflammation when wounds occur, which is the primary reason for the long-term incurable nature of diabetic chronic wounds.
32786521	1	43	theme	diabetes	221:228	arg1	Immunocompromise					175:190	Immunocompromise	175:190	Immunocompromise	175:190	Immunocompromise and impaired angiogenesis of diabetes lead to chronic inflammation when wounds occur, which is the primary reason for the long-term incurable nature of diabetic chronic wounds.
32786521	0	44	theme	HHA	18:20	arg1	Hydrogel					22:29	Dual Cross-linked HHA Hydrogel	0:29	Dual Cross-linked HHA Hydrogel	0:29	Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing.
32786521	3	45	theme	MΦ2	758:760	arg1	hydrogels					762:770	Cu-HHA/PVA@MΦ2 hydrogels	747:770	Cu-HHA/PVA@MΦ2 hydrogels	747:770	MΦ2 are seeded on the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels.
32786521	6	46	theme	other	1297:1301	arg1	groups					1312:1317	other diabetic groups	1297:1317	other diabetic groups	1297:1317	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	3	47	theme	physical	666:673	arg1	cross-linking					675:687	physical cross-linking	666:687	physical cross-linking	666:687	MΦ2 are seeded on the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels.
32786521	4	48	theme	wound	953:957	arg1	bed					959:961	the wound bed	949:961	the wound bed	949:961	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	6	49	theme	nondiabetic	1359:1369	arg1	group					1379:1383	the wild nondiabetic control group	1350:1383	the wild nondiabetic control group	1350:1383	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	0	50	theme	Chronic	152:158	arg1	Healing					166:172	Diabetic Chronic Wound Healing	143:172	Diabetic Chronic Wound Healing	143:172	Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing.
32786521	3	51	theme	cross-linking	675:687	arg1	cross-linking					634:646	Cu2+ cross-linking	629:646	Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels	629:770	MΦ2 are seeded on the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels.
32786521	4	52	theme	phenotype	918:926	arg1	MΦ1					941:943	MΦ1	941:943	MΦ1	941:943	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	4	52	theme	phenotype	918:926	arg1	macrophages					928:938	the M1 phenotype macrophages	911:938	the M1 phenotype macrophages (MΦ1) in the wound bed	911:961	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	6	53	theme	wild	1354:1357	arg1	group					1379:1383	the wild nondiabetic control group	1350:1383	the wild nondiabetic control group	1350:1383	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	1	54	theme	long-term	314:322	arg1	nature					334:339	the long-term incurable nature	310:339	the long-term incurable nature of diabetic chronic wounds	310:366	Immunocompromise and impaired angiogenesis of diabetes lead to chronic inflammation when wounds occur, which is the primary reason for the long-term incurable nature of diabetic chronic wounds.
32786521	0	55	theme	Diabetic	143:150	arg1	Healing					166:172	Diabetic Chronic Wound Healing	143:172	Diabetic Chronic Wound Healing	143:172	Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing.
32786521	3	56	theme	degree	655:660	arg1	cross-linking					634:646	Cu2+ cross-linking	629:646	Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels	629:770	MΦ2 are seeded on the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels.
32786521	6	57	theme	@	1218:1218	arg1	MΦ2					1219:1221	the 0.5Cu-HHA/PVA@MΦ2	1201:1221	the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment	1201:1265	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	2	58	theme	impaired	551:558	arg1	angiogenesis					560:571	impaired angiogenesis	551:571	impaired angiogenesis	551:571	Herein, a high-molecular-weight hyaluronic acid (HHA) hydrogel is developed to supply and regulate M2 phenotype macrophages (MΦ2) for synergistic improvement of immunocompromise and impaired angiogenesis.
32786521	1	59	theme	chronic	238:244	arg1	inflammation					246:257	chronic inflammation	238:257	chronic inflammation	238:257	Immunocompromise and impaired angiogenesis of diabetes lead to chronic inflammation when wounds occur, which is the primary reason for the long-term incurable nature of diabetic chronic wounds.
32786521	2	60	theme	phenotype	471:479	arg1	macrophages					481:491	M2 phenotype macrophages	468:491	M2 phenotype macrophages	468:491	Herein, a high-molecular-weight hyaluronic acid (HHA) hydrogel is developed to supply and regulate M2 phenotype macrophages (MΦ2) for synergistic improvement of immunocompromise and impaired angiogenesis.
32786521	3	61	theme	Cu-HHA/PVA	596:605	arg1	hydrogels					607:615	the Cu-HHA/PVA hydrogels	592:615	the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels	592:770	MΦ2 are seeded on the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels.
32786521	5	62	theme	phase	1104:1108	arg1	transition					1110:1119	the wound-healing phase transition	1086:1119	the wound-healing phase transition from inflammation to proliferation and remodeling	1086:1169	Furthermore, Cu2+ could be released from the hydrogels to further stimulate angiogenesis, thus accelerating the wound-healing phase transition from inflammation to proliferation and remodeling.
32786521	2	63	theme	M2	468:469	arg1	macrophages					481:491	M2 phenotype macrophages	468:491	M2 phenotype macrophages	468:491	Herein, a high-molecular-weight hyaluronic acid (HHA) hydrogel is developed to supply and regulate M2 phenotype macrophages (MΦ2) for synergistic improvement of immunocompromise and impaired angiogenesis.
32786521	7	64	theme	diabetic	1557:1564	arg1	wound					1574:1578	a diabetic chronic wound	1555:1578	a diabetic chronic wound	1555:1578	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	0	65	theme	Wound	160:164	arg1	Healing					166:172	Diabetic Chronic Wound Healing	143:172	Diabetic Chronic Wound Healing	143:172	Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing.
32786521	3	66	theme	freeze-thaw	694:704	arg1	cycle					706:710	one freeze-thaw cycle	690:710	one freeze-thaw cycle	690:710	MΦ2 are seeded on the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels.
32786521	6	67	theme	%	1254:1254	arg1	degree					1244:1249	ionic cross-linking degree	1224:1249	ionic cross-linking degree 0.5%	1224:1254	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	6	68	theme	average	1176:1182	arg1	area					1190:1193	The average wound area	1172:1193	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment	1172:1265	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	6	68	theme	average	1176:1182	arg1	smaller					1276:1282	smaller	1276:1282	smaller	1276:1282	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	6	69	theme	ionic	1224:1228	arg1	degree					1244:1249	ionic cross-linking degree	1224:1249	ionic cross-linking degree 0.5%	1224:1254	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	4	70	from	MΦ2	825:827	arg1	site					842:845	the wound site	832:845	the wound site	832:845	The Cu-HHA/PVA@MΦ2 hydrogel can directly supply the MΦ2 in the wound site, maintain the consistent phenotype of loaded MΦ2, and transform the M1 phenotype macrophages (MΦ1) in the wound bed to MΦ2 by HHA.
32786521	3	71	dep	degree	655:660	arg1	lyophilization					723:736	unique lyophilization	716:736	unique lyophilization	716:736	MΦ2 are seeded on the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels.
32786521	3	71	dep	degree	655:660	arg1	cycle					706:710	one freeze-thaw cycle	690:710	one freeze-thaw cycle	690:710	MΦ2 are seeded on the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels.
32786521	6	72	theme	0.5Cu-HHA/PVA	1205:1217	arg1	MΦ2					1219:1221	the 0.5Cu-HHA/PVA@MΦ2	1201:1221	the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment	1201:1265	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	3	73	theme	low	651:653	arg1	degree					655:660	low degree	651:660	low degree	651:660	MΦ2 are seeded on the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels.
32786521	7	74	theme	chronic	1566:1572	arg1	wound					1574:1578	a diabetic chronic wound	1555:1578	a diabetic chronic wound	1555:1578	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	0	75	theme	Synergistic	62:72	arg1	Improvement					74:84	Synergistic Improvement	62:84	Synergistic Improvement of Immunocompromise and Impaired Angiogenesis	62:130	Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing.
32786521	3	76	theme	Cu2+	629:632	arg1	cross-linking					634:646	Cu2+ cross-linking	629:646	Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels	629:770	MΦ2 are seeded on the Cu-HHA/PVA hydrogels prepared by Cu2+ cross-linking of low degree and physical cross-linking (one freeze-thaw cycle and unique lyophilization) to form Cu-HHA/PVA@MΦ2 hydrogels.
32786521	5	77	attach	released	1005:1012	arg2	Cu2+					991:994	Cu2+	991:994	Cu2+	991:994	Furthermore, Cu2+ could be released from the hydrogels to further stimulate angiogenesis, thus accelerating the wound-healing phase transition from inflammation to proliferation and remodeling.
32786521	5	77	attach	released	1005:1012	arg1	hydrogels					1023:1031	the hydrogels	1019:1031	the hydrogels	1019:1031	Furthermore, Cu2+ could be released from the hydrogels to further stimulate angiogenesis, thus accelerating the wound-healing phase transition from inflammation to proliferation and remodeling.
32786521	2	78	theme	high-molecular-weight	379:399	arg1	hydrogel					423:430	a high-molecular-weight hyaluronic acid (HHA) hydrogel	377:430	a high-molecular-weight hyaluronic acid (HHA) hydrogel	377:430	Herein, a high-molecular-weight hyaluronic acid (HHA) hydrogel is developed to supply and regulate M2 phenotype macrophages (MΦ2) for synergistic improvement of immunocompromise and impaired angiogenesis.
32786521	7	79	theme	treatment	1532:1540	arg1	strategy					1542:1549	a safe and effective treatment strategy	1511:1549	a safe and effective treatment strategy for a diabetic chronic wound	1511:1578	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	7	79	theme	treatment	1532:1540	arg1	strategy					1418:1425	this facile hydrogel strategy	1397:1425	this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis	1397:1498	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	1	80	theme	diabetic	344:351	arg1	wounds					361:366	diabetic chronic wounds	344:366	diabetic chronic wounds	344:366	Immunocompromise and impaired angiogenesis of diabetes lead to chronic inflammation when wounds occur, which is the primary reason for the long-term incurable nature of diabetic chronic wounds.
32786521	6	81	theme	control	1371:1377	arg1	group					1379:1383	the wild nondiabetic control group	1350:1383	the wild nondiabetic control group	1350:1383	The average wound area after the 0.5Cu-HHA/PVA@MΦ2 (ionic cross-linking degree 0.5%) treatment was much smaller than that of other diabetic groups at day 12 and close to that of the wild nondiabetic control group.
32786521	7	82	theme	angiogenesis	1487:1498	arg1	mechanisms					1452:1461	multiple modulation mechanisms	1432:1461	multiple modulation mechanisms of immunocompromise and angiogenesis	1432:1498	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	7	83	with	strategy	1418:1425	arg1	mechanisms					1452:1461	multiple modulation mechanisms	1432:1461	multiple modulation mechanisms of immunocompromise and angiogenesis	1432:1498	Therefore, this facile hydrogel strategy with multiple modulation mechanisms of immunocompromise and angiogenesis may act as a safe and effective treatment strategy for a diabetic chronic wound.
32786521	2	84	theme	immunocompromise	530:545	arg1	improvement					515:525	synergistic improvement	503:525	synergistic improvement of immunocompromise and impaired angiogenesis	503:571	Herein, a high-molecular-weight hyaluronic acid (HHA) hydrogel is developed to supply and regulate M2 phenotype macrophages (MΦ2) for synergistic improvement of immunocompromise and impaired angiogenesis.
33483082	1	0	theme	wetting	172:178	arg1	membranes					180:188	The asymmetric wetting membranes	157:188	The asymmetric wetting membranes	157:188	The asymmetric wetting membranes have attracted intense attention in liquid directional transportation.
33483082	6	1	theme	simulated	1121:1129	arg1	environment					1143:1153	the simulated application environment	1117:1153	the simulated application environment	1117:1153	The antibacterial test revealed that BC-CS had an excellent performance against S. aureus and E. coli in the simulated application environment.
33483082	3	2	theme	polypropylene	521:533	arg1	PPF					552:554	PPF	552:554	PPF	552:554	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	3	2	theme	polypropylene	521:533	arg1	fabric					544:549	polypropylene nonwoven fabric	521:549	polypropylene nonwoven fabric (PPF) substrate	521:565	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	0	3	theme	chitosan	110:117	arg1	layers					149:154	chitosan for sanitary products surface layers	110:154	chitosan for sanitary products surface layers	110:154	Asymmetric wetting and antibacterial composite membrane obtained by spraying bacterial cellulose grafted with chitosan for sanitary products surface layers.
33483082	3	4	theme	wetting	650:656	arg1	BC-CS/PPF					696:704	BC-CS/PPF	696:704	BC-CS/PPF	696:704	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	3	4	theme	wetting	650:656	arg1	membrane					686:693	the asymmetric wetting and antibacterial composite membrane	635:693	the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF)	635:705	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	3	5	theme	nonwoven	535:542	arg1	PPF					552:554	PPF	552:554	PPF	552:554	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	3	5	theme	nonwoven	535:542	arg1	fabric					544:549	polypropylene nonwoven fabric	521:549	polypropylene nonwoven fabric (PPF) substrate	521:565	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	2	6	theme	layer	312:316	arg1	membrane					318:325	surface layer membrane	304:325	surface layer membrane	304:325	However, it is a huge challenge to prepare surface layer membrane for sanitary products with antibacterial and asymmetric wettability by a simple method.
33483082	3	7	theme	easy	571:574	arg1	spraying					615:622	easy and effective one-sided layer-by-layer spraying	571:622	easy and effective one-sided layer-by-layer spraying	571:622	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	2	8	with	products	340:347	arg1	wettability					383:393	antibacterial and asymmetric wettability	354:393	antibacterial and asymmetric wettability	354:393	However, it is a huge challenge to prepare surface layer membrane for sanitary products with antibacterial and asymmetric wettability by a simple method.
33483082	5	9	theme	anti-return	990:1000	arg1	property					1002:1009	anti-return property	990:1009	anti-return property	990:1009	The sanitary products with BC-CS/PPF surface layer, denoted as BC-CS/PPF sanitary products, also had good absorption and anti-return property.
33483082	2	10	theme	surface	304:310	arg1	membrane					318:325	surface layer membrane	304:325	surface layer membrane	304:325	However, it is a huge challenge to prepare surface layer membrane for sanitary products with antibacterial and asymmetric wettability by a simple method.
33483082	3	11	theme	hydrophilic	493:503	arg1	agent					505:509	the hydrophilic agent	489:509	the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying	489:622	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	3	11	theme	hydrophilic	493:503	arg1	cellulose					437:445	the bacterial cellulose	423:445	the bacterial cellulose grafted with chitosan (BC-CS)	423:475	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	0	12	theme	sanitary	123:130	arg1	products					132:139	sanitary products	123:139	sanitary products	123:139	Asymmetric wetting and antibacterial composite membrane obtained by spraying bacterial cellulose grafted with chitosan for sanitary products surface layers.
33483082	5	13	theme	BC-CS/PPF	932:940	arg1	products					951:958	BC-CS/PPF sanitary products	932:958	BC-CS/PPF sanitary products	932:958	The sanitary products with BC-CS/PPF surface layer, denoted as BC-CS/PPF sanitary products, also had good absorption and anti-return property.
33483082	4	14	theme	strong	795:800	arg1	combination					823:833	the strong and uniform physical combination	791:833	the strong and uniform physical combination between nano-sized BC-CS and PPF	791:866	It showed that the BC-CS/PPF had good physical properties, which was attributed to the strong and uniform physical combination between nano-sized BC-CS and PPF.
33483082	5	15	theme	BC-CS/PPF	896:904	arg1	layer					914:918	BC-CS/PPF surface layer	896:918	BC-CS/PPF surface layer	896:918	The sanitary products with BC-CS/PPF surface layer, denoted as BC-CS/PPF sanitary products, also had good absorption and anti-return property.
33483082	7	16	theme	sanitary	1231:1238	arg1	products					1240:1247	commercial sanitary products	1220:1247	commercial sanitary products	1220:1247	Moreover, the antibacterial performance was better than that of commercial sanitary products.
33483082	6	17	from	performance	1072:1082	arg1	environment					1143:1153	the simulated application environment	1117:1153	the simulated application environment	1117:1153	The antibacterial test revealed that BC-CS had an excellent performance against S. aureus and E. coli in the simulated application environment.
33483082	7	18	theme	commercial	1220:1229	arg1	products					1240:1247	commercial sanitary products	1220:1247	commercial sanitary products	1220:1247	Moreover, the antibacterial performance was better than that of commercial sanitary products.
33483082	4	19	contain	had	737:739	arg2	properties					755:764	good physical properties	741:764	good physical properties	741:764	It showed that the BC-CS/PPF had good physical properties, which was attributed to the strong and uniform physical combination between nano-sized BC-CS and PPF.
33483082	4	19	contain	had	737:739	arg1	BC-CS/PPF					727:735	the BC-CS/PPF	723:735	the BC-CS/PPF	723:735	It showed that the BC-CS/PPF had good physical properties, which was attributed to the strong and uniform physical combination between nano-sized BC-CS and PPF.
33483082	1	20	theme	intense	205:211	arg1	attention					213:221	intense attention	205:221	intense attention	205:221	The asymmetric wetting membranes have attracted intense attention in liquid directional transportation.
33483082	4	21	theme	good	741:744	arg1	properties					755:764	good physical properties	741:764	good physical properties	741:764	It showed that the BC-CS/PPF had good physical properties, which was attributed to the strong and uniform physical combination between nano-sized BC-CS and PPF.
33483082	2	22	theme	sanitary	331:338	arg1	products					340:347	sanitary products	331:347	sanitary products with antibacterial and asymmetric wettability	331:393	However, it is a huge challenge to prepare surface layer membrane for sanitary products with antibacterial and asymmetric wettability by a simple method.
33483082	5	23	theme	surface	906:912	arg1	layer					914:918	BC-CS/PPF surface layer	896:918	BC-CS/PPF surface layer	896:918	The sanitary products with BC-CS/PPF surface layer, denoted as BC-CS/PPF sanitary products, also had good absorption and anti-return property.
33483082	0	24	theme	antibacterial	23:35	arg1	membrane					47:54	antibacterial composite membrane	23:54	antibacterial composite membrane	23:54	Asymmetric wetting and antibacterial composite membrane obtained by spraying bacterial cellulose grafted with chitosan for sanitary products surface layers.
33483082	0	25	theme	surface	141:147	arg1	layers					149:154	chitosan for sanitary products surface layers	110:154	chitosan for sanitary products surface layers	110:154	Asymmetric wetting and antibacterial composite membrane obtained by spraying bacterial cellulose grafted with chitosan for sanitary products surface layers.
33483082	5	26	theme	good	970:973	arg1	absorption					975:984	good absorption	970:984	good absorption	970:984	The sanitary products with BC-CS/PPF surface layer, denoted as BC-CS/PPF sanitary products, also had good absorption and anti-return property.
33483082	3	27	theme	effective	580:588	arg1	spraying					615:622	easy and effective one-sided layer-by-layer spraying	571:622	easy and effective one-sided layer-by-layer spraying	571:622	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	6	28	contain	had	1055:1057	arg1	BC-CS					1049:1053	BC-CS	1049:1053	BC-CS	1049:1053	The antibacterial test revealed that BC-CS had an excellent performance against S. aureus and E. coli in the simulated application environment.
33483082	6	28	contain	had	1055:1057	arg2	performance					1072:1082	an excellent performance	1059:1082	an excellent performance against S. aureus and E. coli in the simulated application environment	1059:1153	The antibacterial test revealed that BC-CS had an excellent performance against S. aureus and E. coli in the simulated application environment.
33483082	3	29	theme	composite	676:684	arg1	BC-CS/PPF					696:704	BC-CS/PPF	696:704	BC-CS/PPF	696:704	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	3	29	theme	composite	676:684	arg1	membrane					686:693	the asymmetric wetting and antibacterial composite membrane	635:693	the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF)	635:705	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	3	30	used	used	481:484	arg2	cellulose					437:445	the bacterial cellulose	423:445	the bacterial cellulose grafted with chitosan (BC-CS)	423:475	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	3	30	used	used	481:484	arg2	agent					505:509	the hydrophilic agent	489:509	the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying	489:622	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	5	31	contain	had	966:968	arg2	property					1002:1009	anti-return property	990:1009	anti-return property	990:1009	The sanitary products with BC-CS/PPF surface layer, denoted as BC-CS/PPF sanitary products, also had good absorption and anti-return property.
33483082	5	31	contain	had	966:968	arg2	absorption					975:984	good absorption	970:984	good absorption	970:984	The sanitary products with BC-CS/PPF surface layer, denoted as BC-CS/PPF sanitary products, also had good absorption and anti-return property.
33483082	5	31	contain	had	966:968	arg1	products					882:889	The sanitary products	869:889	The sanitary products	869:889	The sanitary products with BC-CS/PPF surface layer, denoted as BC-CS/PPF sanitary products, also had good absorption and anti-return property.
33483082	1	32	theme	liquid	226:231	arg1	transportation					245:258	liquid directional transportation	226:258	liquid directional transportation	226:258	The asymmetric wetting membranes have attracted intense attention in liquid directional transportation.
33483082	4	33	theme	nano-sized	843:852	arg1	BC-CS					854:858	nano-sized BC-CS	843:858	nano-sized BC-CS	843:858	It showed that the BC-CS/PPF had good physical properties, which was attributed to the strong and uniform physical combination between nano-sized BC-CS and PPF.
33483082	1	34	theme	directional	233:243	arg1	transportation					245:258	liquid directional transportation	226:258	liquid directional transportation	226:258	The asymmetric wetting membranes have attracted intense attention in liquid directional transportation.
33483082	0	35	theme	composite	37:45	arg1	membrane					47:54	antibacterial composite membrane	23:54	antibacterial composite membrane	23:54	Asymmetric wetting and antibacterial composite membrane obtained by spraying bacterial cellulose grafted with chitosan for sanitary products surface layers.
33483082	7	36	theme	antibacterial	1170:1182	arg1	performance					1184:1194	the antibacterial performance	1166:1194	the antibacterial performance	1166:1194	Moreover, the antibacterial performance was better than that of commercial sanitary products.
33483082	7	36	theme	antibacterial	1170:1182	arg1	better					1200:1205	better	1200:1205	better	1200:1205	Moreover, the antibacterial performance was better than that of commercial sanitary products.
33483082	5	37	theme	sanitary	873:880	arg1	products					882:889	The sanitary products	869:889	The sanitary products	869:889	The sanitary products with BC-CS/PPF surface layer, denoted as BC-CS/PPF sanitary products, also had good absorption and anti-return property.
33483082	3	38	theme	antibacterial	662:674	arg1	BC-CS/PPF					696:704	BC-CS/PPF	696:704	BC-CS/PPF	696:704	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	3	38	theme	antibacterial	662:674	arg1	membrane					686:693	the asymmetric wetting and antibacterial composite membrane	635:693	the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF)	635:705	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	3	39	theme	one-sided	590:598	arg1	spraying					615:622	easy and effective one-sided layer-by-layer spraying	571:622	easy and effective one-sided layer-by-layer spraying	571:622	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	6	40	theme	application	1131:1141	arg1	environment					1143:1153	the simulated application environment	1117:1153	the simulated application environment	1117:1153	The antibacterial test revealed that BC-CS had an excellent performance against S. aureus and E. coli in the simulated application environment.
33483082	2	41	theme	asymmetric	372:381	arg1	wettability					383:393	antibacterial and asymmetric wettability	354:393	antibacterial and asymmetric wettability	354:393	However, it is a huge challenge to prepare surface layer membrane for sanitary products with antibacterial and asymmetric wettability by a simple method.
33483082	3	42	theme	bacterial	427:435	arg1	agent					505:509	the hydrophilic agent	489:509	the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying	489:622	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	3	42	theme	bacterial	427:435	arg1	cellulose					437:445	the bacterial cellulose	423:445	the bacterial cellulose grafted with chitosan (BC-CS)	423:475	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	3	43	theme	layer-by-layer	600:613	arg1	spraying					615:622	easy and effective one-sided layer-by-layer spraying	571:622	easy and effective one-sided layer-by-layer spraying	571:622	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	5	44	theme	sanitary	942:949	arg1	products					951:958	BC-CS/PPF sanitary products	932:958	BC-CS/PPF sanitary products	932:958	The sanitary products with BC-CS/PPF surface layer, denoted as BC-CS/PPF sanitary products, also had good absorption and anti-return property.
33483082	5	45	with	products	882:889	arg1	layer					914:918	BC-CS/PPF surface layer	896:918	BC-CS/PPF surface layer	896:918	The sanitary products with BC-CS/PPF surface layer, denoted as BC-CS/PPF sanitary products, also had good absorption and anti-return property.
33483082	4	46	theme	uniform	806:812	arg1	combination					823:833	the strong and uniform physical combination	791:833	the strong and uniform physical combination between nano-sized BC-CS and PPF	791:866	It showed that the BC-CS/PPF had good physical properties, which was attributed to the strong and uniform physical combination between nano-sized BC-CS and PPF.
33483082	3	47	theme	asymmetric	639:648	arg1	BC-CS/PPF					696:704	BC-CS/PPF	696:704	BC-CS/PPF	696:704	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	3	47	theme	asymmetric	639:648	arg1	membrane					686:693	the asymmetric wetting and antibacterial composite membrane	635:693	the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF)	635:705	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
33483082	2	48	theme	antibacterial	354:366	arg1	wettability					383:393	antibacterial and asymmetric wettability	354:393	antibacterial and asymmetric wettability	354:393	However, it is a huge challenge to prepare surface layer membrane for sanitary products with antibacterial and asymmetric wettability by a simple method.
33483082	2	49	theme	huge	278:281	arg1	it					270:271	it	270:271	it	270:271	However, it is a huge challenge to prepare surface layer membrane for sanitary products with antibacterial and asymmetric wettability by a simple method.
33483082	2	49	theme	huge	278:281	arg1	challenge					283:291	a huge challenge	276:291	a huge challenge to prepare surface layer membrane for sanitary products with antibacterial and asymmetric wettability by a simple method	276:412	However, it is a huge challenge to prepare surface layer membrane for sanitary products with antibacterial and asymmetric wettability by a simple method.
33483082	1	50	theme	asymmetric	161:170	arg1	membranes					180:188	The asymmetric wetting membranes	157:188	The asymmetric wetting membranes	157:188	The asymmetric wetting membranes have attracted intense attention in liquid directional transportation.
33483082	4	51	theme	physical	746:753	arg1	properties					755:764	good physical properties	741:764	good physical properties	741:764	It showed that the BC-CS/PPF had good physical properties, which was attributed to the strong and uniform physical combination between nano-sized BC-CS and PPF.
33483082	0	52	theme	bacterial	77:85	arg1	cellulose					87:95	bacterial cellulose	77:95	bacterial cellulose	77:95	Asymmetric wetting and antibacterial composite membrane obtained by spraying bacterial cellulose grafted with chitosan for sanitary products surface layers.
33483082	6	53	theme	excellent	1062:1070	arg1	performance					1072:1082	an excellent performance	1059:1082	an excellent performance against S. aureus and E. coli in the simulated application environment	1059:1153	The antibacterial test revealed that BC-CS had an excellent performance against S. aureus and E. coli in the simulated application environment.
33483082	2	54	theme	simple	400:405	arg1	method					407:412	a simple method	398:412	a simple method	398:412	However, it is a huge challenge to prepare surface layer membrane for sanitary products with antibacterial and asymmetric wettability by a simple method.
33483082	6	55	theme	antibacterial	1016:1028	arg1	test					1030:1033	The antibacterial test	1012:1033	The antibacterial test	1012:1033	The antibacterial test revealed that BC-CS had an excellent performance against S. aureus and E. coli in the simulated application environment.
33483082	4	56	theme	physical	814:821	arg1	combination					823:833	the strong and uniform physical combination	791:833	the strong and uniform physical combination between nano-sized BC-CS and PPF	791:866	It showed that the BC-CS/PPF had good physical properties, which was attributed to the strong and uniform physical combination between nano-sized BC-CS and PPF.
33483082	3	57	theme	fabric	544:549	arg1	substrate					557:565	polypropylene nonwoven fabric (PPF) substrate	521:565	polypropylene nonwoven fabric (PPF) substrate	521:565	Herein, the bacterial cellulose grafted with chitosan (BC-CS) was used as the hydrophilic agent to modify polypropylene nonwoven fabric (PPF) substrate via easy and effective one-sided layer-by-layer spraying to prepare the asymmetric wetting and antibacterial composite membrane (BC-CS/PPF).
32933693	8	0	theme	antibacterial	1257:1269	arg1	activity					1271:1278	their in vitro antibacterial activity	1242:1278	their in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria have been investigated	1242:1361	Cellulose/TiO2 nanocomposite was screened for their in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria have been investigated.
32933693	8	1	theme	Cellulose/TiO2	1196:1209	arg1	nanocomposite					1211:1223	Cellulose/TiO2 nanocomposite	1196:1223	Cellulose/TiO2 nanocomposite	1196:1223	Cellulose/TiO2 nanocomposite was screened for their in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria have been investigated.
32933693	3	2	theme	electron	593:600	arg1	microscopy					602:611	transmission electron microscopy	580:611	transmission electron microscopy	580:611	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	5	3	theme	infrared	857:864	arg1	spectroscopy					866:877	Fourier transfer infrared spectroscopy	840:877	The Fourier transfer infrared spectroscopy investigation	836:891	The Fourier transfer infrared spectroscopy investigation reveals that the TiO2 is bound to hydroxyl groups to the cellulose by hydrogen bonding.
32933693	6	4	from	UV-DRS	1058:1063	arg1	bandgap					1000:1006	The optical energy bandgap	981:1006	The optical energy bandgap	981:1006	The optical energy bandgap is found to be 2.71 eV for nanocomposite from the UV-DRS.
32933693	6	4	from	UV-DRS	1058:1063	arg1	eV					1028:1029	2.71 eV	1023:1029	2.71 eV for nanocomposite from the UV-DRS	1023:1063	The optical energy bandgap is found to be 2.71 eV for nanocomposite from the UV-DRS.
32933693	0	5	theme	in	105:106	arg1	studies					133:139	in vitro antibacterial and in silico molecular docking studies	78:139	in vitro antibacterial and in silico molecular docking studies	78:139	Synthesis and characterization of cellulose/TiO2 nanocomposite: Evaluation of in vitro antibacterial and in silico molecular docking studies.
32933693	10	6	theme	novel	1571:1575	arg1	method					1588:1593	a novel and simple method	1569:1593	a novel and simple method for the synthesis of cellulose/TiO2 nanocomposite as functional biomaterials	1569:1670	This finding provides a novel and simple method for the synthesis of cellulose/TiO2 nanocomposite as functional biomaterials.
32933693	8	7	dep	aureus	1303:1308	arg1	bacteria					1331:1338	bacteria	1331:1338	bacteria	1331:1338	Cellulose/TiO2 nanocomposite was screened for their in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria have been investigated.
32933693	8	7	dep	aureus	1303:1308	arg1	investigated					1350:1361	investigated	1350:1361	have been investigated	1340:1361	Cellulose/TiO2 nanocomposite was screened for their in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria have been investigated.
32933693	7	8	theme	mechanical	1070:1079	arg1	strength					1081:1088	The mechanical strength	1066:1088	The mechanical strength of the composites gently escalated with the addition of TiO2	1066:1149	The mechanical strength of the composites gently escalated with the addition of TiO2 nanoparticles into cellulose polymer matrix.
32933693	3	9	theme	reflectance	638:648	arg1	spectra					650:656	ultraviolet diffuse reflectance spectra	618:656	ultraviolet diffuse reflectance spectra	618:656	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	4	10	theme	size	772:775	arg1	evidence					751:758	evidence	751:758	evidence of particle size ranging from 20 to 40 nm for cellulose/TiO2 nanocomposite	751:833	XRD results showed the anatase structure of TiO2 while FESEM micrograph showed evidence of particle size ranging from 20 to 40 nm for cellulose/TiO2 nanocomposite.
32933693	9	11	dep	in	1404:1405	arg1	silico					1407:1412	silico	1407:1412	silico	1407:1412	Additionally, the results obtained from in silico molecular docking studies confirm the interaction of nanocomposite with proteins, were in good agreement with the experimental data.
32933693	5	12	theme	Fourier	840:846	arg1	spectroscopy					866:877	Fourier transfer infrared spectroscopy	840:877	The Fourier transfer infrared spectroscopy investigation	836:891	The Fourier transfer infrared spectroscopy investigation reveals that the TiO2 is bound to hydroxyl groups to the cellulose by hydrogen bonding.
32933693	10	13	theme	simple	1581:1586	arg1	method					1588:1593	a novel and simple method	1569:1593	a novel and simple method for the synthesis of cellulose/TiO2 nanocomposite as functional biomaterials	1569:1670	This finding provides a novel and simple method for the synthesis of cellulose/TiO2 nanocomposite as functional biomaterials.
32933693	9	14	with	agreement	1509:1517	arg1	data					1541:1544	the experimental data	1524:1544	the experimental data	1524:1544	Additionally, the results obtained from in silico molecular docking studies confirm the interaction of nanocomposite with proteins, were in good agreement with the experimental data.
32933693	4	15	dep	40	796:797	arg1	to					793:794	to	793:794	to	793:794	XRD results showed the anatase structure of TiO2 while FESEM micrograph showed evidence of particle size ranging from 20 to 40 nm for cellulose/TiO2 nanocomposite.
32933693	4	16	theme	anatase	695:701	arg1	structure					703:711	the anatase structure	691:711	the anatase structure of TiO2	691:719	XRD results showed the anatase structure of TiO2 while FESEM micrograph showed evidence of particle size ranging from 20 to 40 nm for cellulose/TiO2 nanocomposite.
32933693	0	17	theme	molecular	115:123	arg1	studies					133:139	in vitro antibacterial and in silico molecular docking studies	78:139	in vitro antibacterial and in silico molecular docking studies	78:139	Synthesis and characterization of cellulose/TiO2 nanocomposite: Evaluation of in vitro antibacterial and in silico molecular docking studies.
32933693	9	18	theme	nanocomposite	1467:1479	arg1	interaction					1452:1462	the interaction	1448:1462	the interaction of nanocomposite with proteins, were in good agreement with the experimental data	1448:1544	Additionally, the results obtained from in silico molecular docking studies confirm the interaction of nanocomposite with proteins, were in good agreement with the experimental data.
32933693	10	19	theme	nanocomposite	1631:1643	arg1	synthesis					1603:1611	the synthesis	1599:1611	the synthesis of cellulose/TiO2 nanocomposite as functional biomaterials	1599:1670	This finding provides a novel and simple method for the synthesis of cellulose/TiO2 nanocomposite as functional biomaterials.
32933693	3	20	theme	scanning	550:557	arg1	microscopy					568:577	field emission scanning electron microscopy	535:577	field emission scanning electron microscopy	535:577	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	0	21	dep	in	105:106	arg1	silico					108:113	silico	108:113	silico	108:113	Synthesis and characterization of cellulose/TiO2 nanocomposite: Evaluation of in vitro antibacterial and in silico molecular docking studies.
32933693	3	22	theme	energy	497:502	arg1	spectroscopy					521:532	energy dispersive X-ray spectroscopy	497:532	energy dispersive X-ray spectroscopy	497:532	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	3	23	theme	X-ray	515:519	arg1	spectroscopy					521:532	energy dispersive X-ray spectroscopy	497:532	energy dispersive X-ray spectroscopy	497:532	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	3	24	theme	optical	416:422	arg1	properties					424:433	optical properties	416:433	optical properties	416:433	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	10	25	theme	cellulose/TiO2	1616:1629	arg1	nanocomposite					1631:1643	cellulose/TiO2 nanocomposite	1616:1643	cellulose/TiO2 nanocomposite	1616:1643	This finding provides a novel and simple method for the synthesis of cellulose/TiO2 nanocomposite as functional biomaterials.
32933693	3	26	theme	diffuse	630:636	arg1	spectra					650:656	ultraviolet diffuse reflectance spectra	618:656	ultraviolet diffuse reflectance spectra	618:656	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	4	27	theme	particle	763:770	arg1	size					772:775	particle size	763:775	particle size ranging from 20 to 40 nm for cellulose/TiO2 nanocomposite	763:833	XRD results showed the anatase structure of TiO2 while FESEM micrograph showed evidence of particle size ranging from 20 to 40 nm for cellulose/TiO2 nanocomposite.
32933693	8	28	dep	in	1248:1249	arg1	vitro					1251:1255	vitro	1251:1255	vitro	1251:1255	Cellulose/TiO2 nanocomposite was screened for their in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria have been investigated.
32933693	6	29	theme	energy	993:998	arg1	bandgap					1000:1006	The optical energy bandgap	981:1006	The optical energy bandgap	981:1006	The optical energy bandgap is found to be 2.71 eV for nanocomposite from the UV-DRS.
32933693	6	29	theme	energy	993:998	arg1	eV					1028:1029	2.71 eV	1023:1029	2.71 eV for nanocomposite from the UV-DRS	1023:1063	The optical energy bandgap is found to be 2.71 eV for nanocomposite from the UV-DRS.
32933693	5	30	theme	spectroscopy	866:877	arg1	investigation					879:891	The Fourier transfer infrared spectroscopy investigation	836:891	The Fourier transfer infrared spectroscopy investigation	836:891	The Fourier transfer infrared spectroscopy investigation reveals that the TiO2 is bound to hydroxyl groups to the cellulose by hydrogen bonding.
32933693	2	31	theme	nanomaterials	375:387	arg1	fabrication					350:360	the fabrication	346:360	the fabrication of composite nanomaterials	346:387	This method was accomplished green and cost-effective for the fabrication of composite nanomaterials.
32933693	3	32	theme	ultraviolet	618:628	arg1	spectra					650:656	ultraviolet diffuse reflectance spectra	618:656	ultraviolet diffuse reflectance spectra	618:656	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	1	33	theme	sodium	208:213	arg1	medium					256:261	sodium hydroxide-thiourea-urea aqueous solution medium	208:261	sodium hydroxide-thiourea-urea aqueous solution medium	208:261	Cellulose/TiO2 nanocomposite was synthesized using coagulation in sodium hydroxide-thiourea-urea aqueous solution medium by precipitation method.
32933693	5	34	theme	hydroxyl	927:934	arg1	groups					936:941	hydroxyl groups	927:941	hydroxyl groups	927:941	The Fourier transfer infrared spectroscopy investigation reveals that the TiO2 is bound to hydroxyl groups to the cellulose by hydrogen bonding.
32933693	9	35	theme	docking	1424:1430	arg1	studies					1432:1438	in silico molecular docking studies	1404:1438	in silico molecular docking studies	1404:1438	Additionally, the results obtained from in silico molecular docking studies confirm the interaction of nanocomposite with proteins, were in good agreement with the experimental data.
32933693	2	36	theme	composite	365:373	arg1	nanomaterials					375:387	composite nanomaterials	365:387	composite nanomaterials	365:387	This method was accomplished green and cost-effective for the fabrication of composite nanomaterials.
32933693	1	37	theme	hydroxide-thiourea-urea	215:237	arg1	medium					256:261	sodium hydroxide-thiourea-urea aqueous solution medium	208:261	sodium hydroxide-thiourea-urea aqueous solution medium	208:261	Cellulose/TiO2 nanocomposite was synthesized using coagulation in sodium hydroxide-thiourea-urea aqueous solution medium by precipitation method.
32933693	0	38	theme	studies	133:139	arg1	Evaluation					64:73	Evaluation	64:73	Evaluation of in vitro antibacterial and in silico molecular docking studies	64:139	Synthesis and characterization of cellulose/TiO2 nanocomposite: Evaluation of in vitro antibacterial and in silico molecular docking studies.
32933693	0	39	dep	in	78:79	arg1	vitro					81:85	vitro	81:85	vitro	81:85	Synthesis and characterization of cellulose/TiO2 nanocomposite: Evaluation of in vitro antibacterial and in silico molecular docking studies.
32933693	0	39	dep	in	78:79	arg1	antibacterial					87:99	antibacterial	87:99	antibacterial	87:99	Synthesis and characterization of cellulose/TiO2 nanocomposite: Evaluation of in vitro antibacterial and in silico molecular docking studies.
32933693	9	40	theme	experimental	1528:1539	arg1	data					1541:1544	the experimental data	1524:1544	the experimental data	1524:1544	Additionally, the results obtained from in silico molecular docking studies confirm the interaction of nanocomposite with proteins, were in good agreement with the experimental data.
32933693	3	41	theme	emission	541:548	arg1	microscopy					568:577	field emission scanning electron microscopy	535:577	field emission scanning electron microscopy	535:577	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	3	42	theme	nanocomposite	442:454	arg1	morphology					401:410	morphology	401:410	morphology	401:410	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	3	42	theme	nanocomposite	442:454	arg1	properties					424:433	optical properties	416:433	optical properties	416:433	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	3	42	theme	nanocomposite	442:454	arg1	Structure					390:398	Structure	390:398	Structure	390:398	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	0	43	theme	docking	125:131	arg1	studies					133:139	in vitro antibacterial and in silico molecular docking studies	78:139	in vitro antibacterial and in silico molecular docking studies	78:139	Synthesis and characterization of cellulose/TiO2 nanocomposite: Evaluation of in vitro antibacterial and in silico molecular docking studies.
32933693	6	44	theme	optical	985:991	arg1	bandgap					1000:1006	The optical energy bandgap	981:1006	The optical energy bandgap	981:1006	The optical energy bandgap is found to be 2.71 eV for nanocomposite from the UV-DRS.
32933693	6	44	theme	optical	985:991	arg1	eV					1028:1029	2.71 eV	1023:1029	2.71 eV for nanocomposite from the UV-DRS	1023:1063	The optical energy bandgap is found to be 2.71 eV for nanocomposite from the UV-DRS.
32933693	9	45	with	interaction	1452:1462	arg1	proteins					1486:1493	proteins	1486:1493	proteins	1486:1493	Additionally, the results obtained from in silico molecular docking studies confirm the interaction of nanocomposite with proteins, were in good agreement with the experimental data.
32933693	1	46	theme	solution	247:254	arg1	medium					256:261	sodium hydroxide-thiourea-urea aqueous solution medium	208:261	sodium hydroxide-thiourea-urea aqueous solution medium	208:261	Cellulose/TiO2 nanocomposite was synthesized using coagulation in sodium hydroxide-thiourea-urea aqueous solution medium by precipitation method.
32933693	4	47	theme	XRD	672:674	arg1	results					676:682	XRD results	672:682	XRD results	672:682	XRD results showed the anatase structure of TiO2 while FESEM micrograph showed evidence of particle size ranging from 20 to 40 nm for cellulose/TiO2 nanocomposite.
32933693	10	48	theme	functional	1648:1657	arg1	biomaterials					1659:1670	functional biomaterials	1648:1670	functional biomaterials	1648:1670	This finding provides a novel and simple method for the synthesis of cellulose/TiO2 nanocomposite as functional biomaterials.
32933693	3	49	theme	dispersive	504:513	arg1	spectroscopy					521:532	energy dispersive X-ray spectroscopy	497:532	energy dispersive X-ray spectroscopy	497:532	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	0	50	theme	cellulose/TiO2	34:47	arg1	characterization					14:29	characterization	14:29	characterization	14:29	Synthesis and characterization of cellulose/TiO2 nanocomposite: Evaluation of in vitro antibacterial and in silico molecular docking studies.
32933693	0	50	theme	cellulose/TiO2	34:47	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis and characterization of cellulose/TiO2 nanocomposite: Evaluation of in vitro antibacterial and in silico molecular docking studies.
32933693	7	51	theme	cellulose	1170:1178	arg1	matrix					1188:1193	cellulose polymer matrix	1170:1193	cellulose polymer matrix	1170:1193	The mechanical strength of the composites gently escalated with the addition of TiO2 nanoparticles into cellulose polymer matrix.
32933693	3	52	theme	field	535:539	arg1	microscopy					568:577	field emission scanning electron microscopy	535:577	field emission scanning electron microscopy	535:577	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	7	53	theme	TiO2	1146:1149	arg1	addition					1134:1141	the addition	1130:1141	the addition of TiO2	1130:1149	The mechanical strength of the composites gently escalated with the addition of TiO2 nanoparticles into cellulose polymer matrix.
32933693	4	54	theme	cellulose/TiO2	806:819	arg1	nanocomposite					821:833	cellulose/TiO2 nanocomposite	806:833	cellulose/TiO2 nanocomposite	806:833	XRD results showed the anatase structure of TiO2 while FESEM micrograph showed evidence of particle size ranging from 20 to 40 nm for cellulose/TiO2 nanocomposite.
32933693	3	55	theme	X-ray	478:482	arg1	diffraction					484:494	X-ray diffraction	478:494	X-ray diffraction	478:494	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	7	56	theme	polymer	1180:1186	arg1	matrix					1188:1193	cellulose polymer matrix	1170:1193	cellulose polymer matrix	1170:1193	The mechanical strength of the composites gently escalated with the addition of TiO2 nanoparticles into cellulose polymer matrix.
32933693	9	57	theme	in	1404:1405	arg1	studies					1432:1438	in silico molecular docking studies	1404:1438	in silico molecular docking studies	1404:1438	Additionally, the results obtained from in silico molecular docking studies confirm the interaction of nanocomposite with proteins, were in good agreement with the experimental data.
32933693	3	58	theme	transmission	580:591	arg1	microscopy					602:611	transmission electron microscopy	580:611	transmission electron microscopy	580:611	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	7	59	theme	composites	1097:1106	arg1	strength					1081:1088	The mechanical strength	1066:1088	The mechanical strength of the composites gently escalated with the addition of TiO2	1066:1149	The mechanical strength of the composites gently escalated with the addition of TiO2 nanoparticles into cellulose polymer matrix.
32933693	8	60	theme	in	1248:1249	arg1	activity					1271:1278	their in vitro antibacterial activity	1242:1278	their in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria have been investigated	1242:1361	Cellulose/TiO2 nanocomposite was screened for their in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria have been investigated.
32933693	9	61	theme	good	1504:1507	arg1	agreement					1509:1517	good agreement	1504:1517	good agreement with the experimental data	1504:1544	Additionally, the results obtained from in silico molecular docking studies confirm the interaction of nanocomposite with proteins, were in good agreement with the experimental data.
32933693	3	62	theme	electron	559:566	arg1	microscopy					568:577	field emission scanning electron microscopy	535:577	field emission scanning electron microscopy	535:577	Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.
32933693	1	63	theme	precipitation	266:278	arg1	method					280:285	precipitation method	266:285	precipitation method	266:285	Cellulose/TiO2 nanocomposite was synthesized using coagulation in sodium hydroxide-thiourea-urea aqueous solution medium by precipitation method.
32933693	9	64	theme	molecular	1414:1422	arg1	studies					1432:1438	in silico molecular docking studies	1404:1438	in silico molecular docking studies	1404:1438	Additionally, the results obtained from in silico molecular docking studies confirm the interaction of nanocomposite with proteins, were in good agreement with the experimental data.
32933693	1	65	theme	Cellulose/TiO2	142:155	arg1	nanocomposite					157:169	Cellulose/TiO2 nanocomposite	142:169	Cellulose/TiO2 nanocomposite	142:169	Cellulose/TiO2 nanocomposite was synthesized using coagulation in sodium hydroxide-thiourea-urea aqueous solution medium by precipitation method.
32933693	0	66	theme	in	78:79	arg1	studies					133:139	in vitro antibacterial and in silico molecular docking studies	78:139	in vitro antibacterial and in silico molecular docking studies	78:139	Synthesis and characterization of cellulose/TiO2 nanocomposite: Evaluation of in vitro antibacterial and in silico molecular docking studies.
32933693	5	67	theme	hydrogen	963:970	arg1	bonding					972:978	hydrogen bonding	963:978	hydrogen bonding	963:978	The Fourier transfer infrared spectroscopy investigation reveals that the TiO2 is bound to hydroxyl groups to the cellulose by hydrogen bonding.
32933693	1	68	theme	aqueous	239:245	arg1	medium					256:261	sodium hydroxide-thiourea-urea aqueous solution medium	208:261	sodium hydroxide-thiourea-urea aqueous solution medium	208:261	Cellulose/TiO2 nanocomposite was synthesized using coagulation in sodium hydroxide-thiourea-urea aqueous solution medium by precipitation method.
32933693	4	69	theme	FESEM	727:731	arg1	micrograph					733:742	FESEM micrograph	727:742	FESEM micrograph	727:742	XRD results showed the anatase structure of TiO2 while FESEM micrograph showed evidence of particle size ranging from 20 to 40 nm for cellulose/TiO2 nanocomposite.
32933693	1	70	from	coagulation	193:203	arg1	medium					256:261	sodium hydroxide-thiourea-urea aqueous solution medium	208:261	sodium hydroxide-thiourea-urea aqueous solution medium	208:261	Cellulose/TiO2 nanocomposite was synthesized using coagulation in sodium hydroxide-thiourea-urea aqueous solution medium by precipitation method.
32933693	4	71	theme	TiO2	716:719	arg1	structure					703:711	the anatase structure	691:711	the anatase structure of TiO2	691:719	XRD results showed the anatase structure of TiO2 while FESEM micrograph showed evidence of particle size ranging from 20 to 40 nm for cellulose/TiO2 nanocomposite.
32933693	5	72	theme	transfer	848:855	arg1	spectroscopy					866:877	Fourier transfer infrared spectroscopy	840:877	The Fourier transfer infrared spectroscopy investigation	836:891	The Fourier transfer infrared spectroscopy investigation reveals that the TiO2 is bound to hydroxyl groups to the cellulose by hydrogen bonding.
32148005	0	0	theme	wound	100:104	arg1	dressing					106:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	[Preparation and characterization of a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing].
32148005	3	1	theme	different	486:494	arg1	ratios					496:501	different ratios	486:501	different ratios	486:501	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	0	2	theme	fibroin	92:98	arg1	dressing					106:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	[Preparation and characterization of a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing].
32148005	4	3	theme	water	831:835	arg1	absorption					837:846	water absorption	831:846	water absorption	831:846	The hemostasis of chitosan dressing was improved by introducing PRP, but the porous structure and water absorption were not significantly improved.
32148005	3	4	theme	PRP	620:622	arg1	effects					609:615	the effects	605:615	the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release	605:730	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	7	5	theme	burst	1195:1199	arg1	release					1201:1207	the burst release	1191:1207	the burst release of growth factors on initial stage	1191:1242	In addition, the dressings with ratio of 1:1 had positive effects on reducing the burst release of growth factors on initial stage.
32148005	6	6	dep	%	1075:1075	arg1	%					1081:1081	±3.84%	1076:1081	86.83%±3.84%	1070:1081	The porosity and water absorption could reach 86.83%±3.84% and 1 474%±114% respectively.
32148005	5	7	theme	1:1	932:934	arg1	ratio					923:927	the ratio	919:927	the ratio of 1:1	919:934	If silk fibroin solution was added in the ratio of 1:1, the more uniform porous structure and better hemostatic performance could be obtained.
32148005	2	8	dep	ratios	347:352	arg1	1:0					373:375	1:0	373:375	1:0	373:375	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0) were added to improve the porosity and hemostasis of materials.
32148005	2	8	dep	ratios	347:352	arg1	3:1					365:367	3:1	365:367	3:1	365:367	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0) were added to improve the porosity and hemostasis of materials.
32148005	2	8	dep	ratios	347:352	arg1	1:3					360:362	1:3	360:362	1:3	360:362	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0) were added to improve the porosity and hemostasis of materials.
32148005	2	8	dep	ratios	347:352	arg1	1:1					355:357	1:1	355:357	1:1	355:357	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0) were added to improve the porosity and hemostasis of materials.
32148005	0	9	theme	dressing	106:113	arg1	characterization					17:32	characterization	17:32	characterization	17:32	[Preparation and characterization of a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing].
32148005	0	9	theme	dressing	106:113	arg1	[Preparation					0:11	[Preparation	0:11	[Preparation	0:11	[Preparation and characterization of a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing].
32148005	3	10	theme	growth	703:708	arg1	factors					710:716	the growth factors burst release	699:730	the growth factors burst release	699:730	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	8	11	theme	PRP-chitosan/silk	1256:1272	arg1	dressing					1292:1299	PRP-chitosan/silk fibroin composite dressing	1256:1299	PRP-chitosan/silk fibroin composite dressing	1256:1299	Therefore, PRP-chitosan/silk fibroin composite dressing can become a kind of wound dressing that can achieve rapid hemostasis and promote wound healing.
32148005	3	12	theme	pure	537:540	arg1	dressing					551:558	pure chitosan dressing	537:558	pure chitosan dressing	537:558	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	3	12	theme	pure	537:540	arg1	group					590:594	the control group	578:594	the control group	578:594	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	2	13	with	solutions	315:323	arg1	ratios					347:352	different volume ratios	330:352	different volume ratios (1:1, 1:3, 3:1 and 1:0)	330:376	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0) were added to improve the porosity and hemostasis of materials.
32148005	7	14	contain	had	1158:1160	arg1	dressings					1130:1138	the dressings	1126:1138	the dressings with ratio of 1:1	1126:1156	In addition, the dressings with ratio of 1:1 had positive effects on reducing the burst release of growth factors on initial stage.
32148005	7	14	contain	had	1158:1160	arg2	effects					1171:1177	positive effects	1162:1177	positive effects	1162:1177	In addition, the dressings with ratio of 1:1 had positive effects on reducing the burst release of growth factors on initial stage.
32148005	2	15	dep	porosity	404:411	arg1	the					400:402	the	400:402	the	400:402	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0) were added to improve the porosity and hemostasis of materials.
32148005	4	16	theme	dressing	760:767	arg1	hemostasis					737:746	The hemostasis	733:746	The hemostasis of chitosan dressing	733:767	The hemostasis of chitosan dressing was improved by introducing PRP, but the porous structure and water absorption were not significantly improved.
32148005	1	17	theme	wound	175:179	arg1	dressings					181:189	wound dressings	175:189	wound dressings	175:189	In order to further improve the hemostatic performance of wound dressings, human platelet-rich plasma (PRP) containing various growth factors was introduced into chitosan solution.
32148005	5	18	theme	silk	884:887	arg1	solution					897:904	silk fibroin solution	884:904	silk fibroin solution	884:904	If silk fibroin solution was added in the ratio of 1:1, the more uniform porous structure and better hemostatic performance could be obtained.
32148005	4	19	theme	porous	810:815	arg1	structure					817:825	the porous structure	806:825	the porous structure	806:825	The hemostasis of chitosan dressing was improved by introducing PRP, but the porous structure and water absorption were not significantly improved.
32148005	4	20	theme	chitosan	751:758	arg1	dressing					760:767	chitosan dressing	751:767	chitosan dressing	751:767	The hemostasis of chitosan dressing was improved by introducing PRP, but the porous structure and water absorption were not significantly improved.
32148005	8	21	theme	wound	1322:1326	arg1	dressing					1328:1335	wound dressing	1322:1335	wound dressing	1322:1335	Therefore, PRP-chitosan/silk fibroin composite dressing can become a kind of wound dressing that can achieve rapid hemostasis and promote wound healing.
32148005	1	22	theme	dressings	181:189	arg1	performance					160:170	the hemostatic performance	145:170	the hemostatic performance of wound dressings	145:189	In order to further improve the hemostatic performance of wound dressings, human platelet-rich plasma (PRP) containing various growth factors was introduced into chitosan solution.
32148005	3	23	from	proportions	654:664	arg1	effects					609:615	the effects	605:615	the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release	605:730	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	3	24	with	dressings	471:479	arg1	ratios					496:501	different ratios	486:501	different ratios	486:501	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	3	25	from	fibroin	633:639	arg1	proportions					654:664	different proportions	644:664	different proportions	644:664	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	3	26	from	effects	609:615	arg1	factors					710:716	the growth factors burst release	699:730	the growth factors burst release	699:730	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	3	26	from	effects	609:615	arg1	properties					684:693	the hemostasis properties	669:693	the hemostasis properties	669:693	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	3	26	from	effects	609:615	arg1	proportions					654:664	different proportions	644:664	different proportions	644:664	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	1	27	theme	chitosan	279:286	arg1	solution					288:295	chitosan solution	279:295	chitosan solution	279:295	In order to further improve the hemostatic performance of wound dressings, human platelet-rich plasma (PRP) containing various growth factors was introduced into chitosan solution.
32148005	7	28	from	release	1201:1207	arg1	stage					1238:1242	initial stage	1230:1242	initial stage	1230:1242	In addition, the dressings with ratio of 1:1 had positive effects on reducing the burst release of growth factors on initial stage.
32148005	1	29	theme	human	192:196	arg1	plasma					212:217	human platelet-rich plasma	192:217	human platelet-rich plasma (PRP) containing various growth factors	192:257	In order to further improve the hemostatic performance of wound dressings, human platelet-rich plasma (PRP) containing various growth factors was introduced into chitosan solution.
32148005	1	29	theme	human	192:196	arg1	PRP					220:222	PRP	220:222	PRP	220:222	In order to further improve the hemostatic performance of wound dressings, human platelet-rich plasma (PRP) containing various growth factors was introduced into chitosan solution.
32148005	6	30	theme	water	1041:1045	arg1	absorption					1047:1056	water absorption	1041:1056	water absorption	1041:1056	The porosity and water absorption could reach 86.83%±3.84% and 1 474%±114% respectively.
32148005	8	31	theme	wound	1383:1387	arg1	healing					1389:1395	wound healing	1383:1395	wound healing	1383:1395	Therefore, PRP-chitosan/silk fibroin composite dressing can become a kind of wound dressing that can achieve rapid hemostasis and promote wound healing.
32148005	6	32	theme	474	1089:1091	arg1	%					1097:1097	1 474%±114%	1087:1097	1 474%±114% respectively	1087:1110	The porosity and water absorption could reach 86.83%±3.84% and 1 474%±114% respectively.
32148005	2	33	theme	fibroin	307:313	arg1	solutions					315:323	The silk fibroin solutions	298:323	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0)	298:376	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0) were added to improve the porosity and hemostasis of materials.
32148005	5	34	theme	better	975:980	arg1	performance					993:1003	better hemostatic performance	975:1003	better hemostatic performance	975:1003	If silk fibroin solution was added in the ratio of 1:1, the more uniform porous structure and better hemostatic performance could be obtained.
32148005	1	35	theme	platelet-rich	198:210	arg1	plasma					212:217	human platelet-rich plasma	192:217	human platelet-rich plasma (PRP) containing various growth factors	192:257	In order to further improve the hemostatic performance of wound dressings, human platelet-rich plasma (PRP) containing various growth factors was introduced into chitosan solution.
32148005	1	35	theme	platelet-rich	198:210	arg1	PRP					220:222	PRP	220:222	PRP	220:222	In order to further improve the hemostatic performance of wound dressings, human platelet-rich plasma (PRP) containing various growth factors was introduced into chitosan solution.
32148005	3	36	theme	burst	718:722	arg1	release					724:730	burst release	718:730	the growth factors burst release	699:730	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	2	37	theme	silk	302:305	arg1	solutions					315:323	The silk fibroin solutions	298:323	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0)	298:376	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0) were added to improve the porosity and hemostasis of materials.
32148005	7	38	theme	initial	1230:1236	arg1	stage					1238:1242	initial stage	1230:1242	initial stage	1230:1242	In addition, the dressings with ratio of 1:1 had positive effects on reducing the burst release of growth factors on initial stage.
32148005	0	39	theme	hemostatic	39:48	arg1	dressing					106:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	[Preparation and characterization of a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing].
32148005	7	40	with	dressings	1130:1138	arg1	ratio					1145:1149	ratio	1145:1149	ratio of 1:1	1145:1156	In addition, the dressings with ratio of 1:1 had positive effects on reducing the burst release of growth factors on initial stage.
32148005	3	41	theme	silk	628:631	arg1	fibroin					633:639	silk fibroin	628:639	silk fibroin	628:639	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	3	42	theme	control	582:588	arg1	dressing					551:558	pure chitosan dressing	537:558	pure chitosan dressing	537:558	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	3	42	theme	control	582:588	arg1	group					590:594	the control group	578:594	the control group	578:594	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	7	43	theme	growth	1212:1217	arg1	factors					1219:1225	growth factors	1212:1225	growth factors	1212:1225	In addition, the dressings with ratio of 1:1 had positive effects on reducing the burst release of growth factors on initial stage.
32148005	5	44	theme	hemostatic	982:991	arg1	performance					993:1003	better hemostatic performance	975:1003	better hemostatic performance	975:1003	If silk fibroin solution was added in the ratio of 1:1, the more uniform porous structure and better hemostatic performance could be obtained.
32148005	7	45	theme	factors	1219:1225	arg1	release					1201:1207	the burst release	1191:1207	the burst release of growth factors on initial stage	1191:1242	In addition, the dressings with ratio of 1:1 had positive effects on reducing the burst release of growth factors on initial stage.
32148005	2	46	theme	materials	431:439	arg1	hemostasis					417:426	hemostasis	417:426	hemostasis	417:426	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0) were added to improve the porosity and hemostasis of materials.
32148005	2	46	theme	materials	431:439	arg1	porosity					404:411	porosity	404:411	porosity	404:411	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0) were added to improve the porosity and hemostasis of materials.
32148005	8	47	theme	fibroin	1274:1280	arg1	dressing					1292:1299	PRP-chitosan/silk fibroin composite dressing	1256:1299	PRP-chitosan/silk fibroin composite dressing	1256:1299	Therefore, PRP-chitosan/silk fibroin composite dressing can become a kind of wound dressing that can achieve rapid hemostasis and promote wound healing.
32148005	0	48	theme	plasma	71:76	arg1	dressing					106:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	[Preparation and characterization of a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing].
32148005	1	49	contain	containing	225:234	arg1	plasma					212:217	human platelet-rich plasma	192:217	human platelet-rich plasma (PRP) containing various growth factors	192:257	In order to further improve the hemostatic performance of wound dressings, human platelet-rich plasma (PRP) containing various growth factors was introduced into chitosan solution.
32148005	1	49	contain	containing	225:234	arg2	factors					251:257	various growth factors	236:257	various growth factors	236:257	In order to further improve the hemostatic performance of wound dressings, human platelet-rich plasma (PRP) containing various growth factors was introduced into chitosan solution.
32148005	1	49	contain	containing	225:234	arg1	PRP					220:222	PRP	220:222	PRP	220:222	In order to further improve the hemostatic performance of wound dressings, human platelet-rich plasma (PRP) containing various growth factors was introduced into chitosan solution.
32148005	5	50	theme	fibroin	889:895	arg1	solution					897:904	silk fibroin solution	884:904	silk fibroin solution	884:904	If silk fibroin solution was added in the ratio of 1:1, the more uniform porous structure and better hemostatic performance could be obtained.
32148005	0	51	theme	porous	50:55	arg1	dressing					106:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	[Preparation and characterization of a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing].
32148005	7	52	theme	1:1	1154:1156	arg1	ratio					1145:1149	ratio	1145:1149	ratio of 1:1	1145:1156	In addition, the dressings with ratio of 1:1 had positive effects on reducing the burst release of growth factors on initial stage.
32148005	3	53	theme	different	644:652	arg1	proportions					654:664	different proportions	644:664	different proportions	644:664	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	6	54	theme	%	1092:1092	arg1	%					1097:1097	1 474%±114%	1087:1097	1 474%±114% respectively	1087:1110	The porosity and water absorption could reach 86.83%±3.84% and 1 474%±114% respectively.
32148005	3	55	dep	factors	710:716	arg1	release					724:730	burst release	718:730	the growth factors burst release	699:730	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	5	56	theme	uniform	946:952	arg1	structure					961:969	the more uniform porous structure	937:969	the more uniform porous structure	937:969	If silk fibroin solution was added in the ratio of 1:1, the more uniform porous structure and better hemostatic performance could be obtained.
32148005	2	57	theme	volume	340:345	arg1	ratios					347:352	different volume ratios	330:352	different volume ratios (1:1, 1:3, 3:1 and 1:0)	330:376	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0) were added to improve the porosity and hemostasis of materials.
32148005	3	58	theme	chitosan	542:549	arg1	dressing					551:558	pure chitosan dressing	537:558	pure chitosan dressing	537:558	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	3	58	theme	chitosan	542:549	arg1	group					590:594	the control group	578:594	the control group	578:594	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	8	59	theme	composite	1282:1290	arg1	dressing					1292:1299	PRP-chitosan/silk fibroin composite dressing	1256:1299	PRP-chitosan/silk fibroin composite dressing	1256:1299	Therefore, PRP-chitosan/silk fibroin composite dressing can become a kind of wound dressing that can achieve rapid hemostasis and promote wound healing.
32148005	3	60	theme	fibroin	633:639	arg1	effects					609:615	the effects	605:615	the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release	605:730	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	5	61	theme	porous	954:959	arg1	structure					961:969	the more uniform porous structure	937:969	the more uniform porous structure	937:969	If silk fibroin solution was added in the ratio of 1:1, the more uniform porous structure and better hemostatic performance could be obtained.
32148005	2	62	theme	different	330:338	arg1	ratios					347:352	different volume ratios	330:352	different volume ratios (1:1, 1:3, 3:1 and 1:0)	330:376	The silk fibroin solutions with different volume ratios (1:1, 1:3, 3:1 and 1:0) were added to improve the porosity and hemostasis of materials.
32148005	3	63	theme	hPRP-chitosan/silk	446:463	arg1	dressings					471:479	The hPRP-chitosan/silk wound dressings	442:479	The hPRP-chitosan/silk wound dressings with different ratios	442:501	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	0	64	theme	chitosan/silk	78:90	arg1	dressing					106:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	[Preparation and characterization of a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing].
32148005	8	65	theme	dressing	1328:1335	arg1	kind					1314:1317	a kind	1312:1317	a kind of wound dressing that can achieve rapid hemostasis and promote wound healing	1312:1395	Therefore, PRP-chitosan/silk fibroin composite dressing can become a kind of wound dressing that can achieve rapid hemostasis and promote wound healing.
32148005	3	66	theme	wound	465:469	arg1	dressings					471:479	The hPRP-chitosan/silk wound dressings	442:479	The hPRP-chitosan/silk wound dressings with different ratios	442:501	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	1	67	theme	various	236:242	arg1	factors					251:257	various growth factors	236:257	various growth factors	236:257	In order to further improve the hemostatic performance of wound dressings, human platelet-rich plasma (PRP) containing various growth factors was introduced into chitosan solution.
32148005	0	68	theme	platelet-rich	57:69	arg1	dressing					106:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing	37:113	[Preparation and characterization of a hemostatic porous platelet-rich plasma chitosan/silk fibroin wound dressing].
32148005	3	69	theme	hemostasis	673:682	arg1	properties					684:693	the hemostasis properties	669:693	the hemostasis properties	669:693	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	8	70	theme	rapid	1354:1358	arg1	hemostasis					1360:1369	rapid hemostasis	1354:1369	rapid hemostasis	1354:1369	Therefore, PRP-chitosan/silk fibroin composite dressing can become a kind of wound dressing that can achieve rapid hemostasis and promote wound healing.
32148005	3	71	from	PRP	620:622	arg1	proportions					654:664	different proportions	644:664	different proportions	644:664	The hPRP-chitosan/silk wound dressings with different ratios was prepared by freeze-drying and pure chitosan dressing was considered as the control group to study the effects of PRP and silk fibroin in different proportions on the hemostasis properties and the growth factors burst release.
32148005	1	72	theme	hemostatic	149:158	arg1	performance					160:170	the hemostatic performance	145:170	the hemostatic performance of wound dressings	145:189	In order to further improve the hemostatic performance of wound dressings, human platelet-rich plasma (PRP) containing various growth factors was introduced into chitosan solution.
32148005	7	73	theme	positive	1162:1169	arg1	effects					1171:1177	positive effects	1162:1177	positive effects	1162:1177	In addition, the dressings with ratio of 1:1 had positive effects on reducing the burst release of growth factors on initial stage.
32148005	1	74	theme	growth	244:249	arg1	factors					251:257	various growth factors	236:257	various growth factors	236:257	In order to further improve the hemostatic performance of wound dressings, human platelet-rich plasma (PRP) containing various growth factors was introduced into chitosan solution.
32510928	4	0	theme	interior	503:510	arg1	colonies					512:519	interior colonies	503:519	interior colonies	503:519	Nitric oxide (NO) can both disrupt the physical structure of the biofilm and eradicate interior colonies.
32510928	5	1	theme	tracking	678:685	arg1	microrheology					687:699	parallel plate macrorheology and particle tracking microrheology	636:699	parallel plate macrorheology and particle tracking microrheology	636:699	The effects of a CF-like growth environment on P. aeruginosa biofilm susceptibility to NO were investigated using parallel plate macrorheology and particle tracking microrheology.
32510928	5	2	theme	CF-like	539:545	arg1	environment					554:564	a CF-like growth environment	537:564	a CF-like growth environment	537:564	The effects of a CF-like growth environment on P. aeruginosa biofilm susceptibility to NO were investigated using parallel plate macrorheology and particle tracking microrheology.
32510928	1	3	theme	fibrosis	173:180	arg1	patients					187:194	cystic fibrosis (CF) patients	166:194	cystic fibrosis (CF) patients	166:194	Pseudomonas aeruginosa is the main contributor to the morbidity and mortality of cystic fibrosis (CF) patients.
32510928	3	4	theme	biofilm	329:335	arg1	matrix					337:342	the biofilm matrix	325:342	the biofilm matrix	325:342	The composition of the biofilm matrix determines its viscoelastic properties and affects antibiotic efficacy.
32510928	7	5	theme	viscoelastic	914:925	arg1	moduli					927:932	Greater viscoelastic moduli	906:932	Greater viscoelastic moduli	906:932	Greater viscoelastic moduli correlated with increased tolerance to tobramycin and colistin.
32510928	4	6	theme	Nitric	416:421	arg1	oxide					423:427	Nitric oxide	416:427	Nitric oxide (NO)	416:432	Nitric oxide (NO) can both disrupt the physical structure of the biofilm and eradicate interior colonies.
32510928	4	6	theme	Nitric	416:421	arg1	NO					430:431	NO	430:431	NO	430:431	Nitric oxide (NO) can both disrupt the physical structure of the biofilm and eradicate interior colonies.
32510928	9	7	theme	conventional	1286:1297	arg1	antibiotics					1299:1309	conventional antibiotics	1286:1309	conventional antibiotics	1286:1309	The capacity of NO-releasing cyclodextrins to eradicate P. aeruginosa biofilms irrespective of matrix composition suggests that NO-based therapies may be superior antibiofilm treatments compared to conventional antibiotics.
32510928	4	8	theme	biofilm	481:487	arg1	structure					464:472	the physical structure	451:472	the physical structure of the biofilm	451:487	Nitric oxide (NO) can both disrupt the physical structure of the biofilm and eradicate interior colonies.
32510928	7	9	theme	increased	950:958	arg1	tolerance					960:968	increased tolerance	950:968	increased tolerance to tobramycin and colistin	950:995	Greater viscoelastic moduli correlated with increased tolerance to tobramycin and colistin.
32510928	2	10	theme	biofilm	290:296	arg1	matrix					298:303	the biofilm matrix	286:303	the biofilm matrix	286:303	Chronic respiratory infections are rarely eradicated due to protection from CF mucus and the biofilm matrix.
32510928	6	11	theme	DNA	747:749	arg1	presence					724:731	the presence	720:731	the presence of mucins and DNA	720:749	Biofilms grown in the presence of mucins and DNA contained greater concentrations of DNA in the matrix and exhibited concomitantly larger viscoelastic moduli compared to those grown in tryptic soy broth.
32510928	9	12	theme	NO-based	1216:1223	arg1	therapies					1225:1233	NO-based therapies	1216:1233	NO-based therapies	1216:1233	The capacity of NO-releasing cyclodextrins to eradicate P. aeruginosa biofilms irrespective of matrix composition suggests that NO-based therapies may be superior antibiofilm treatments compared to conventional antibiotics.
32510928	5	13	theme	plate	645:649	arg1	macrorheology					651:663	plate macrorheology	645:663	plate macrorheology	645:663	The effects of a CF-like growth environment on P. aeruginosa biofilm susceptibility to NO were investigated using parallel plate macrorheology and particle tracking microrheology.
32510928	5	14	theme	parallel	636:643	arg1	microrheology					687:699	parallel plate macrorheology and particle tracking microrheology	636:699	parallel plate macrorheology and particle tracking microrheology	636:699	The effects of a CF-like growth environment on P. aeruginosa biofilm susceptibility to NO were investigated using parallel plate macrorheology and particle tracking microrheology.
32510928	6	15	contain	contained	751:759	arg2	Biofilms					702:709	Biofilms	702:709	Biofilms grown in the presence of mucins and DNA	702:749	Biofilms grown in the presence of mucins and DNA contained greater concentrations of DNA in the matrix and exhibited concomitantly larger viscoelastic moduli compared to those grown in tryptic soy broth.
32510928	6	15	contain	contained	751:759	arg1	matrix					798:803	the matrix	794:803	the matrix	794:803	Biofilms grown in the presence of mucins and DNA contained greater concentrations of DNA in the matrix and exhibited concomitantly larger viscoelastic moduli compared to those grown in tryptic soy broth.
32510928	6	15	contain	contained	751:759	arg2	concentrations					769:782	greater concentrations	761:782	greater concentrations of DNA	761:789	Biofilms grown in the presence of mucins and DNA contained greater concentrations of DNA in the matrix and exhibited concomitantly larger viscoelastic moduli compared to those grown in tryptic soy broth.
32510928	6	15	contain	contained	751:759	arg1	Biofilms					702:709	Biofilms	702:709	Biofilms grown in the presence of mucins and DNA	702:749	Biofilms grown in the presence of mucins and DNA contained greater concentrations of DNA in the matrix and exhibited concomitantly larger viscoelastic moduli compared to those grown in tryptic soy broth.
32510928	5	16	from	effects	526:532	arg1	susceptibility					591:604	P. aeruginosa biofilm susceptibility	569:604	P. aeruginosa biofilm susceptibility to NO	569:610	The effects of a CF-like growth environment on P. aeruginosa biofilm susceptibility to NO were investigated using parallel plate macrorheology and particle tracking microrheology.
32510928	3	17	theme	viscoelastic	359:370	arg1	properties					372:381	its viscoelastic properties	355:381	its viscoelastic properties	355:381	The composition of the biofilm matrix determines its viscoelastic properties and affects antibiotic efficacy.
32510928	5	18	theme	macrorheology	651:663	arg1	microrheology					687:699	parallel plate macrorheology and particle tracking microrheology	636:699	parallel plate macrorheology and particle tracking microrheology	636:699	The effects of a CF-like growth environment on P. aeruginosa biofilm susceptibility to NO were investigated using parallel plate macrorheology and particle tracking microrheology.
32510928	5	19	theme	biofilm	583:589	arg1	susceptibility					591:604	P. aeruginosa biofilm susceptibility	569:604	P. aeruginosa biofilm susceptibility to NO	569:610	The effects of a CF-like growth environment on P. aeruginosa biofilm susceptibility to NO were investigated using parallel plate macrorheology and particle tracking microrheology.
32510928	6	20	theme	mucins	736:741	arg1	presence					724:731	the presence	720:731	the presence of mucins and DNA	720:749	Biofilms grown in the presence of mucins and DNA contained greater concentrations of DNA in the matrix and exhibited concomitantly larger viscoelastic moduli compared to those grown in tryptic soy broth.
32510928	8	21	theme	same	1068:1071	arg1	concentration					1073:1085	the same concentration	1064:1085	the same concentration	1064:1085	Remarkably, NO-releasing cyclodextrins eradicated all biofilms at the same concentration.
32510928	1	22	theme	patients	187:194	arg1	mortality					153:161	mortality	153:161	mortality	153:161	Pseudomonas aeruginosa is the main contributor to the morbidity and mortality of cystic fibrosis (CF) patients.
32510928	1	22	theme	patients	187:194	arg1	morbidity					139:147	morbidity	139:147	morbidity	139:147	Pseudomonas aeruginosa is the main contributor to the morbidity and mortality of cystic fibrosis (CF) patients.
32510928	0	23	theme	Pseudomonas	0:10	arg1	Eradication					31:41	Pseudomonas aeruginosa Biofilm Eradication	0:41	Pseudomonas aeruginosa Biofilm Eradication	0:41	Pseudomonas aeruginosa Biofilm Eradication via Nitric Oxide-Releasing Cyclodextrins.
32510928	5	24	theme	particle	669:676	arg1	tracking					678:685	particle tracking	669:685	particle tracking	669:685	The effects of a CF-like growth environment on P. aeruginosa biofilm susceptibility to NO were investigated using parallel plate macrorheology and particle tracking microrheology.
32510928	1	25	theme	main	115:118	arg1	aeruginosa					97:106	Pseudomonas aeruginosa	85:106	Pseudomonas aeruginosa	85:106	Pseudomonas aeruginosa is the main contributor to the morbidity and mortality of cystic fibrosis (CF) patients.
32510928	1	25	theme	main	115:118	arg1	contributor					120:130	the main contributor	111:130	the main contributor to the morbidity and mortality of cystic fibrosis (CF) patients	111:194	Pseudomonas aeruginosa is the main contributor to the morbidity and mortality of cystic fibrosis (CF) patients.
32510928	6	26	theme	viscoelastic	840:851	arg1	moduli					853:858	concomitantly larger viscoelastic moduli	819:858	concomitantly larger viscoelastic moduli	819:858	Biofilms grown in the presence of mucins and DNA contained greater concentrations of DNA in the matrix and exhibited concomitantly larger viscoelastic moduli compared to those grown in tryptic soy broth.
32510928	3	27	theme	antibiotic	395:404	arg1	efficacy					406:413	antibiotic efficacy	395:413	antibiotic efficacy	395:413	The composition of the biofilm matrix determines its viscoelastic properties and affects antibiotic efficacy.
32510928	4	28	theme	physical	455:462	arg1	structure					464:472	the physical structure	451:472	the physical structure of the biofilm	451:487	Nitric oxide (NO) can both disrupt the physical structure of the biofilm and eradicate interior colonies.
32510928	2	29	from	mucus	276:280	arg1	protection					257:266	protection	257:266	protection from CF mucus and the biofilm matrix	257:303	Chronic respiratory infections are rarely eradicated due to protection from CF mucus and the biofilm matrix.
32510928	0	30	theme	Nitric	47:52	arg1	Cyclodextrins					70:82	Nitric Oxide-Releasing Cyclodextrins	47:82	Nitric Oxide-Releasing Cyclodextrins	47:82	Pseudomonas aeruginosa Biofilm Eradication via Nitric Oxide-Releasing Cyclodextrins.
32510928	7	31	theme	Greater	906:912	arg1	moduli					927:932	Greater viscoelastic moduli	906:932	Greater viscoelastic moduli	906:932	Greater viscoelastic moduli correlated with increased tolerance to tobramycin and colistin.
32510928	9	32	theme	P. aeruginosa	1144:1156	arg1	biofilms					1158:1165	P. aeruginosa biofilms	1144:1165	P. aeruginosa biofilms	1144:1165	The capacity of NO-releasing cyclodextrins to eradicate P. aeruginosa biofilms irrespective of matrix composition suggests that NO-based therapies may be superior antibiofilm treatments compared to conventional antibiotics.
32510928	9	33	theme	antibiofilm	1251:1261	arg1	treatments					1263:1272	superior antibiofilm treatments	1242:1272	superior antibiofilm treatments	1242:1272	The capacity of NO-releasing cyclodextrins to eradicate P. aeruginosa biofilms irrespective of matrix composition suggests that NO-based therapies may be superior antibiofilm treatments compared to conventional antibiotics.
32510928	0	34	theme	Biofilm	23:29	arg1	Eradication					31:41	Pseudomonas aeruginosa Biofilm Eradication	0:41	Pseudomonas aeruginosa Biofilm Eradication	0:41	Pseudomonas aeruginosa Biofilm Eradication via Nitric Oxide-Releasing Cyclodextrins.
32510928	5	35	theme	growth	547:552	arg1	environment					554:564	a CF-like growth environment	537:564	a CF-like growth environment	537:564	The effects of a CF-like growth environment on P. aeruginosa biofilm susceptibility to NO were investigated using parallel plate macrorheology and particle tracking microrheology.
32510928	6	36	theme	soy	895:897	arg1	broth					899:903	tryptic soy broth	887:903	tryptic soy broth	887:903	Biofilms grown in the presence of mucins and DNA contained greater concentrations of DNA in the matrix and exhibited concomitantly larger viscoelastic moduli compared to those grown in tryptic soy broth.
32510928	5	37	theme	environment	554:564	arg1	effects					526:532	The effects	522:532	The effects of a CF-like growth environment on P. aeruginosa biofilm susceptibility to NO	522:610	The effects of a CF-like growth environment on P. aeruginosa biofilm susceptibility to NO were investigated using parallel plate macrorheology and particle tracking microrheology.
32510928	0	38	theme	Oxide-Releasing	54:68	arg1	Cyclodextrins					70:82	Nitric Oxide-Releasing Cyclodextrins	47:82	Nitric Oxide-Releasing Cyclodextrins	47:82	Pseudomonas aeruginosa Biofilm Eradication via Nitric Oxide-Releasing Cyclodextrins.
32510928	6	39	theme	tryptic	887:893	arg1	broth					899:903	tryptic soy broth	887:903	tryptic soy broth	887:903	Biofilms grown in the presence of mucins and DNA contained greater concentrations of DNA in the matrix and exhibited concomitantly larger viscoelastic moduli compared to those grown in tryptic soy broth.
32510928	9	40	theme	superior	1242:1249	arg1	treatments					1263:1272	superior antibiofilm treatments	1242:1272	superior antibiofilm treatments	1242:1272	The capacity of NO-releasing cyclodextrins to eradicate P. aeruginosa biofilms irrespective of matrix composition suggests that NO-based therapies may be superior antibiofilm treatments compared to conventional antibiotics.
32510928	9	41	theme	NO-releasing	1104:1115	arg1	cyclodextrins					1117:1129	NO-releasing cyclodextrins	1104:1129	NO-releasing cyclodextrins	1104:1129	The capacity of NO-releasing cyclodextrins to eradicate P. aeruginosa biofilms irrespective of matrix composition suggests that NO-based therapies may be superior antibiofilm treatments compared to conventional antibiotics.
32510928	6	42	theme	larger	833:838	arg1	moduli					853:858	concomitantly larger viscoelastic moduli	819:858	concomitantly larger viscoelastic moduli	819:858	Biofilms grown in the presence of mucins and DNA contained greater concentrations of DNA in the matrix and exhibited concomitantly larger viscoelastic moduli compared to those grown in tryptic soy broth.
32510928	5	43	theme	P. aeruginosa	569:581	arg1	susceptibility					591:604	P. aeruginosa biofilm susceptibility	569:604	P. aeruginosa biofilm susceptibility to NO	569:610	The effects of a CF-like growth environment on P. aeruginosa biofilm susceptibility to NO were investigated using parallel plate macrorheology and particle tracking microrheology.
32510928	6	44	theme	DNA	787:789	arg1	concentrations					769:782	greater concentrations	761:782	greater concentrations of DNA	761:789	Biofilms grown in the presence of mucins and DNA contained greater concentrations of DNA in the matrix and exhibited concomitantly larger viscoelastic moduli compared to those grown in tryptic soy broth.
32510928	2	45	theme	respiratory	205:215	arg1	infections					217:226	Chronic respiratory infections	197:226	Chronic respiratory infections	197:226	Chronic respiratory infections are rarely eradicated due to protection from CF mucus and the biofilm matrix.
32510928	2	46	theme	CF	273:274	arg1	mucus					276:280	CF mucus	273:280	CF mucus	273:280	Chronic respiratory infections are rarely eradicated due to protection from CF mucus and the biofilm matrix.
32510928	8	47	theme	NO-releasing	1010:1021	arg1	cyclodextrins					1023:1035	NO-releasing cyclodextrins	1010:1035	NO-releasing cyclodextrins	1010:1035	Remarkably, NO-releasing cyclodextrins eradicated all biofilms at the same concentration.
32510928	2	48	from	matrix	298:303	arg1	protection					257:266	protection	257:266	protection from CF mucus and the biofilm matrix	257:303	Chronic respiratory infections are rarely eradicated due to protection from CF mucus and the biofilm matrix.
32510928	9	49	theme	matrix	1183:1188	arg1	composition					1190:1200	matrix composition	1183:1200	matrix composition	1183:1200	The capacity of NO-releasing cyclodextrins to eradicate P. aeruginosa biofilms irrespective of matrix composition suggests that NO-based therapies may be superior antibiofilm treatments compared to conventional antibiotics.
32510928	3	50	theme	matrix	337:342	arg1	composition					310:320	The composition	306:320	The composition of the biofilm matrix	306:342	The composition of the biofilm matrix determines its viscoelastic properties and affects antibiotic efficacy.
32510928	2	51	theme	Chronic	197:203	arg1	infections					217:226	Chronic respiratory infections	197:226	Chronic respiratory infections	197:226	Chronic respiratory infections are rarely eradicated due to protection from CF mucus and the biofilm matrix.
32510928	9	52	theme	cyclodextrins	1117:1129	arg1	capacity					1092:1099	The capacity	1088:1099	The capacity of NO-releasing cyclodextrins to eradicate P. aeruginosa biofilms irrespective of matrix composition	1088:1200	The capacity of NO-releasing cyclodextrins to eradicate P. aeruginosa biofilms irrespective of matrix composition suggests that NO-based therapies may be superior antibiofilm treatments compared to conventional antibiotics.
32510928	0	53	dep	Pseudomonas	0:10	arg1	aeruginosa					12:21	aeruginosa	12:21	aeruginosa	12:21	Pseudomonas aeruginosa Biofilm Eradication via Nitric Oxide-Releasing Cyclodextrins.
32510928	6	54	theme	greater	761:767	arg1	concentrations					769:782	greater concentrations	761:782	greater concentrations of DNA	761:789	Biofilms grown in the presence of mucins and DNA contained greater concentrations of DNA in the matrix and exhibited concomitantly larger viscoelastic moduli compared to those grown in tryptic soy broth.
32510928	1	55	theme	cystic	166:171	arg1	CF					183:184	CF	183:184	CF	183:184	Pseudomonas aeruginosa is the main contributor to the morbidity and mortality of cystic fibrosis (CF) patients.
32510928	1	55	theme	cystic	166:171	arg1	fibrosis					173:180	cystic fibrosis	166:180	cystic fibrosis (CF) patients	166:194	Pseudomonas aeruginosa is the main contributor to the morbidity and mortality of cystic fibrosis (CF) patients.
32534088	2	0	theme	25	436:437	arg1	%					438:438	%	438:438	%	438:438	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	3	1	theme	input	609:613	arg1	variables					615:623	the input variables	605:623	the input variables that affected the synthesis of the adsorbent and the adsorption of RR120 dye	605:700	Box-Behnken design (BBD) was applied to optimize the input variables that affected the synthesis of the adsorbent and the adsorption of RR120 dye.
32534088	2	2	theme	FA	476:477	arg1	CS-TPP/FA-50					490:501	CS-TPP/FA-50	490:501	CS-TPP/FA-50	490:501	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	2	2	theme	FA	476:477	arg1	particles					479:487	50% FA particles	472:487	50% FA particles (CS-TPP/FA-50)	472:502	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	1	3	mod	modified	187:194	arg3	powder					214:219	fly ash (FA) powder	201:219	fly ash (FA) powder	201:219	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	1	3	mod	modified	187:194	arg1	CS					168:169	CS	168:169	CS	168:169	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	1	3	mod	modified	187:194	arg1	Chitosan					158:165	Chitosan	158:165	Chitosan (CS)	158:170	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	6	4	theme	adsorption	1048:1057	arg1	equilibrium					1059:1069	The adsorption equilibrium	1044:1069	The adsorption equilibrium	1044:1069	The adsorption equilibrium was described by the Freundlich model, with 165.8 mg/g at 45 °C as the maximum adsorption capacity of CS-TPP/FA-50 for RR120 dye.
32534088	5	5	theme	adsorbent	956:964	arg1	dosage					966:971	adsorbent dosage	956:971	adsorbent dosage of 0.07 g	956:981	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	4	6	dep	C	796:796	arg1	4-10					799:802	4-10	799:802	4-10	799:802	These variables included FA loading (A: 0-50%), adsorbent dose (B: 0.04-0.1 g), solution pH (C: 4-10), temperature (D: 30 °C-60 °C), and time (E: 30-90 min).
32534088	6	7	from	45 °C	1129:1133	arg1	165.8 mg/g					1115:1124	165.8 mg/g	1115:1124	165.8 mg/g at 45 °C as the maximum adsorption capacity of CS-TPP/FA-50 for RR120 dye	1115:1198	The adsorption equilibrium was described by the Freundlich model, with 165.8 mg/g at 45 °C as the maximum adsorption capacity of CS-TPP/FA-50 for RR120 dye.
32534088	3	8	theme	Box-Behnken	556:566	arg1	design					568:573	Box-Behnken design	556:573	Box-Behnken design (BBD)	556:579	Box-Behnken design (BBD) was applied to optimize the input variables that affected the synthesis of the adsorbent and the adsorption of RR120 dye.
32534088	3	8	theme	Box-Behnken	556:566	arg1	BBD					576:578	BBD	576:578	BBD	576:578	Box-Behnken design (BBD) was applied to optimize the input variables that affected the synthesis of the adsorbent and the adsorption of RR120 dye.
32534088	7	9	theme	aqueous	1304:1310	arg1	environment					1312:1322	the aqueous environment	1300:1322	the aqueous environment	1300:1322	This work introduces CS-TPP/FA-50 as an ideal composite adsorbent for removal of textile dyes from the aqueous environment.
32534088	0	10	theme	red	99:101	arg1	dye					107:109	reactive red 120 dye	90:109	reactive red 120 dye	90:109	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye: Statistical optimization and mechanism study.
32534088	1	11	theme	cross-linked	311:322	arg1	composite					334:342	a cross-linked CS-TPP/FA composite	309:342	a cross-linked CS-TPP/FA composite	309:342	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	4	12	theme	adsorbent	751:759	arg1	B					767:767	B	767:767	B	767:767	These variables included FA loading (A: 0-50%), adsorbent dose (B: 0.04-0.1 g), solution pH (C: 4-10), temperature (D: 30 °C-60 °C), and time (E: 30-90 min).
32534088	4	12	theme	adsorbent	751:759	arg1	dose					761:764	adsorbent dose	751:764	adsorbent dose (B: 0.04-0.1 g)	751:780	These variables included FA loading (A: 0-50%), adsorbent dose (B: 0.04-0.1 g), solution pH (C: 4-10), temperature (D: 30 °C-60 °C), and time (E: 30-90 min).
32534088	1	13	theme	dye	400:402	arg1	removal					361:367	removal	361:367	removal of reactive orange 120 (RR120) dye	361:402	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	5	14	theme	45 °C	1017:1021	arg1	solution					984:991	solution	984:991	solution of pH 4	984:999	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	14	theme	45 °C	1017:1021	arg1	time					1028:1031	time	1028:1031	time of 60 min	1028:1041	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	14	theme	45 °C	1017:1021	arg1	CS-TPP/FA-50					940:951	CS-TPP/FA-50	940:951	CS-TPP/FA-50 at adsorbent dosage of 0.07 g	940:981	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	14	theme	45 °C	1017:1021	arg1	temperature					1002:1012	temperature	1002:1012	temperature of 45 °C	1002:1021	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	7	15	theme	dyes	1290:1293	arg1	removal					1271:1277	removal	1271:1277	removal of textile dyes from the aqueous environment	1271:1322	This work introduces CS-TPP/FA-50 as an ideal composite adsorbent for removal of textile dyes from the aqueous environment.
32534088	0	16	theme	reactive	90:97	arg1	dye					107:109	reactive red 120 dye	90:109	reactive red 120 dye	90:109	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye: Statistical optimization and mechanism study.
32534088	1	17	theme	CS-TPP/FA	324:332	arg1	composite					334:342	a cross-linked CS-TPP/FA composite	309:342	a cross-linked CS-TPP/FA composite	309:342	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	4	18	dep	E	846:846	arg1	30-90 min					849:857	30-90 min	849:857	E: 30-90 min	846:857	These variables included FA loading (A: 0-50%), adsorbent dose (B: 0.04-0.1 g), solution pH (C: 4-10), temperature (D: 30 °C-60 °C), and time (E: 30-90 min).
32534088	5	19	theme	0.07 g	976:981	arg1	dosage					966:971	adsorbent dosage	956:971	adsorbent dosage of 0.07 g	956:981	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	0	20	theme	dye	107:109	arg1	removal					79:85	removal	79:85	removal of reactive red 120 dye	79:109	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye: Statistical optimization and mechanism study.
32534088	2	21	theme	CS-TPP	548:553	arg1	structure					535:543	the molecular structure	521:543	the molecular structure of CS-TPP	521:553	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	5	22	theme	highest	887:893	arg1	removal					895:901	the highest removal	883:901	the highest removal (88.8%) of RR120 dye	883:922	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	22	theme	highest	887:893	arg1	%					908:908	88.8%	904:908	88.8%	904:908	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	6	23	theme	adsorption	1150:1159	arg1	capacity					1161:1168	the maximum adsorption capacity	1138:1168	the maximum adsorption capacity of CS-TPP/FA-50 for RR120 dye	1138:1198	The adsorption equilibrium was described by the Freundlich model, with 165.8 mg/g at 45 °C as the maximum adsorption capacity of CS-TPP/FA-50 for RR120 dye.
32534088	1	24	with	reaction	261:268	arg1	TPP					293:295	TPP	293:295	TPP	293:295	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	1	24	with	reaction	261:268	arg1	tripolyphosphate					275:290	tripolyphosphate	275:290	tripolyphosphate (TPP)	275:296	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	4	25	dep	B	767:767	arg1	0.04-0.1 g					770:779	0.04-0.1 g	770:779	0.04-0.1 g	770:779	These variables included FA loading (A: 0-50%), adsorbent dose (B: 0.04-0.1 g), solution pH (C: 4-10), temperature (D: 30 °C-60 °C), and time (E: 30-90 min).
32534088	4	26	theme	solution	783:790	arg1	pH					792:793	solution pH	783:793	solution pH (C: 4-10)	783:803	These variables included FA loading (A: 0-50%), adsorbent dose (B: 0.04-0.1 g), solution pH (C: 4-10), temperature (D: 30 °C-60 °C), and time (E: 30-90 min).
32534088	6	27	theme	Freundlich	1092:1101	arg1	model					1103:1107	the Freundlich model	1088:1107	the Freundlich model	1088:1107	The adsorption equilibrium was described by the Freundlich model, with 165.8 mg/g at 45 °C as the maximum adsorption capacity of CS-TPP/FA-50 for RR120 dye.
32534088	2	28	theme	Different	405:413	arg1	particles					443:451	25% FA particles	436:451	25% FA particles (CS-TPP/FA-25)	436:466	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	2	28	theme	Different	405:413	arg1	particles					479:487	50% FA particles	472:487	50% FA particles (CS-TPP/FA-50)	472:502	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	2	28	theme	Different	405:413	arg1	ratios					415:420	Different ratios	405:420	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50)	405:502	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	5	29	from	dosage	966:971	arg1	solution					984:991	solution	984:991	solution of pH 4	984:999	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	29	from	dosage	966:971	arg1	time					1028:1031	time	1028:1031	time of 60 min	1028:1041	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	29	from	dosage	966:971	arg1	CS-TPP/FA-50					940:951	CS-TPP/FA-50	940:951	CS-TPP/FA-50 at adsorbent dosage of 0.07 g	940:981	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	29	from	dosage	966:971	arg1	temperature					1002:1012	temperature	1002:1012	temperature of 45 °C	1002:1021	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	0	30	theme	Physicochemical	0:14	arg1	modification					16:27	Physicochemical modification	0:27	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye	0:109	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye: Statistical optimization and mechanism study.
32534088	1	31	theme	chemical	238:245	arg1	reaction					261:268	chemical cross-linking reaction	238:268	chemical cross-linking reaction with tripolyphosphate (TPP)	238:296	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	2	32	theme	molecular	525:533	arg1	structure					535:543	the molecular structure	521:543	the molecular structure of CS-TPP	521:553	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	4	33	dep	time	840:843	arg1	E					846:846	E	846:846	E: 30-90 min	846:857	These variables included FA loading (A: 0-50%), adsorbent dose (B: 0.04-0.1 g), solution pH (C: 4-10), temperature (D: 30 °C-60 °C), and time (E: 30-90 min).
32534088	5	34	theme	60 min	1036:1041	arg1	solution					984:991	solution	984:991	solution of pH 4	984:999	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	34	theme	60 min	1036:1041	arg1	time					1028:1031	time	1028:1031	time of 60 min	1028:1041	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	34	theme	60 min	1036:1041	arg1	CS-TPP/FA-50					940:951	CS-TPP/FA-50	940:951	CS-TPP/FA-50 at adsorbent dosage of 0.07 g	940:981	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	34	theme	60 min	1036:1041	arg1	temperature					1002:1012	temperature	1002:1012	temperature of 45 °C	1002:1021	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	0	35	theme	chitosan	32:39	arg1	modification					16:27	Physicochemical modification	0:27	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye	0:109	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye: Statistical optimization and mechanism study.
32534088	1	36	theme	cross-linking	247:259	arg1	reaction					261:268	chemical cross-linking reaction	238:268	chemical cross-linking reaction with tripolyphosphate (TPP)	238:296	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	0	37	theme	Statistical	112:122	arg1	study					151:155	Statistical optimization and mechanism study	112:155	Statistical optimization and mechanism study	112:155	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye: Statistical optimization and mechanism study.
32534088	1	38	link	cross-linked	311:322	arg1	composite					334:342	a cross-linked CS-TPP/FA composite	309:342	a cross-linked CS-TPP/FA composite	309:342	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	2	39	theme	%	474:474	arg1	CS-TPP/FA-50					490:501	CS-TPP/FA-50	490:501	CS-TPP/FA-50	490:501	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	2	39	theme	%	474:474	arg1	particles					479:487	50% FA particles	472:487	50% FA particles (CS-TPP/FA-50)	472:502	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	6	40	theme	maximum	1142:1148	arg1	capacity					1161:1168	the maximum adsorption capacity	1138:1168	the maximum adsorption capacity of CS-TPP/FA-50 for RR120 dye	1138:1198	The adsorption equilibrium was described by the Freundlich model, with 165.8 mg/g at 45 °C as the maximum adsorption capacity of CS-TPP/FA-50 for RR120 dye.
32534088	0	41	theme	fly	46:48	arg1	ash					50:52	fly ash	46:52	fly ash	46:52	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye: Statistical optimization and mechanism study.
32534088	2	42	theme	50	472:473	arg1	%					474:474	%	474:474	%	474:474	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	7	43	theme	textile	1282:1288	arg1	dyes					1290:1293	textile dyes	1282:1293	textile dyes	1282:1293	This work introduces CS-TPP/FA-50 as an ideal composite adsorbent for removal of textile dyes from the aqueous environment.
32534088	2	44	theme	FA	425:426	arg1	particles					443:451	25% FA particles	436:451	25% FA particles (CS-TPP/FA-25)	436:466	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	2	44	theme	FA	425:426	arg1	particles					479:487	50% FA particles	472:487	50% FA particles (CS-TPP/FA-50)	472:502	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	2	44	theme	FA	425:426	arg1	ratios					415:420	Different ratios	405:420	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50)	405:502	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	0	45	theme	optimization	124:135	arg1	study					151:155	Statistical optimization and mechanism study	112:155	Statistical optimization and mechanism study	112:155	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye: Statistical optimization and mechanism study.
32534088	4	46	dep	A	740:740	arg1	%					747:747	0-50%	743:747	0-50%	743:747	These variables included FA loading (A: 0-50%), adsorbent dose (B: 0.04-0.1 g), solution pH (C: 4-10), temperature (D: 30 °C-60 °C), and time (E: 30-90 min).
32534088	1	47	theme	fly	201:203	arg1	FA					210:211	FA	210:211	FA	210:211	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	1	47	theme	fly	201:203	arg1	ash					205:207	fly ash	201:207	fly ash (FA) powder	201:219	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	7	48	theme	ideal	1241:1245	arg1	composite					1247:1255	an ideal composite	1238:1255	an ideal composite adsorbent for removal of textile dyes from the aqueous environment	1238:1322	This work introduces CS-TPP/FA-50 as an ideal composite adsorbent for removal of textile dyes from the aqueous environment.
32534088	7	48	theme	ideal	1241:1245	arg1	CS-TPP/FA-50					1222:1233	CS-TPP/FA-50	1222:1233	CS-TPP/FA-50	1222:1233	This work introduces CS-TPP/FA-50 as an ideal composite adsorbent for removal of textile dyes from the aqueous environment.
32534088	4	49	dep	temperature	806:816	arg1	D					819:819	D	819:819	D: 30 °C-60 °C	819:832	These variables included FA loading (A: 0-50%), adsorbent dose (B: 0.04-0.1 g), solution pH (C: 4-10), temperature (D: 30 °C-60 °C), and time (E: 30-90 min).
32534088	1	50	theme	reactive	372:379	arg1	dye					400:402	reactive orange 120 (RR120) dye	372:402	reactive orange 120 (RR120) dye	372:402	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	6	51	theme	CS-TPP/FA-50	1173:1184	arg1	capacity					1161:1168	the maximum adsorption capacity	1138:1168	the maximum adsorption capacity of CS-TPP/FA-50 for RR120 dye	1138:1198	The adsorption equilibrium was described by the Freundlich model, with 165.8 mg/g at 45 °C as the maximum adsorption capacity of CS-TPP/FA-50 for RR120 dye.
32534088	3	52	theme	adsorbent	660:668	arg1	synthesis					643:651	the synthesis	639:651	the synthesis of the adsorbent	639:668	Box-Behnken design (BBD) was applied to optimize the input variables that affected the synthesis of the adsorbent and the adsorption of RR120 dye.
32534088	3	52	theme	adsorbent	660:668	arg1	adsorption					678:687	the adsorption	674:687	the adsorption of RR120 dye	674:700	Box-Behnken design (BBD) was applied to optimize the input variables that affected the synthesis of the adsorbent and the adsorption of RR120 dye.
32534088	4	53	dep	pH	792:793	arg1	C					796:796	C	796:796	C: 4-10	796:802	These variables included FA loading (A: 0-50%), adsorbent dose (B: 0.04-0.1 g), solution pH (C: 4-10), temperature (D: 30 °C-60 °C), and time (E: 30-90 min).
32534088	5	54	theme	dye	920:922	arg1	removal					895:901	the highest removal	883:901	the highest removal (88.8%) of RR120 dye	883:922	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	54	theme	dye	920:922	arg1	%					908:908	88.8%	904:908	88.8%	904:908	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	0	55	theme	mechanism	141:149	arg1	study					151:155	Statistical optimization and mechanism study	112:155	Statistical optimization and mechanism study	112:155	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye: Statistical optimization and mechanism study.
32534088	1	56	theme	orange	381:386	arg1	dye					400:402	reactive orange 120 (RR120) dye	372:402	reactive orange 120 (RR120) dye	372:402	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	4	57	theme	FA	728:729	arg1	A					740:740	A	740:740	A	740:740	These variables included FA loading (A: 0-50%), adsorbent dose (B: 0.04-0.1 g), solution pH (C: 4-10), temperature (D: 30 °C-60 °C), and time (E: 30-90 min).
32534088	4	57	theme	FA	728:729	arg1	loading					731:737	FA loading	728:737	FA loading (A: 0-50%)	728:748	These variables included FA loading (A: 0-50%), adsorbent dose (B: 0.04-0.1 g), solution pH (C: 4-10), temperature (D: 30 °C-60 °C), and time (E: 30-90 min).
32534088	0	58	with	modification	16:27	arg1	tripolyphosphate					58:73	tripolyphosphate	58:73	tripolyphosphate	58:73	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye: Statistical optimization and mechanism study.
32534088	0	58	with	modification	16:27	arg1	ash					50:52	fly ash	46:52	fly ash	46:52	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye: Statistical optimization and mechanism study.
32534088	4	59	dep	D	819:819	arg1	30 °C-60 °C					822:832	30 °C-60 °C	822:832	30 °C-60 °C	822:832	These variables included FA loading (A: 0-50%), adsorbent dose (B: 0.04-0.1 g), solution pH (C: 4-10), temperature (D: 30 °C-60 °C), and time (E: 30-90 min).
32534088	7	60	theme	adsorbent	1257:1265	arg1	composite					1247:1255	an ideal composite	1238:1255	an ideal composite adsorbent for removal of textile dyes from the aqueous environment	1238:1322	This work introduces CS-TPP/FA-50 as an ideal composite adsorbent for removal of textile dyes from the aqueous environment.
32534088	7	60	theme	adsorbent	1257:1265	arg1	CS-TPP/FA-50					1222:1233	CS-TPP/FA-50	1222:1233	CS-TPP/FA-50	1222:1233	This work introduces CS-TPP/FA-50 as an ideal composite adsorbent for removal of textile dyes from the aqueous environment.
32534088	0	61	dep	study	151:155	arg1	modification					16:27	Physicochemical modification	0:27	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye	0:109	Physicochemical modification of chitosan with fly ash and tripolyphosphate for removal of reactive red 120 dye: Statistical optimization and mechanism study.
32534088	1	62	theme	ash	205:207	arg1	powder					214:219	fly ash (FA) powder	201:219	fly ash (FA) powder	201:219	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	7	63	from	environment	1312:1322	arg1	removal					1271:1277	removal	1271:1277	removal of textile dyes from the aqueous environment	1271:1322	This work introduces CS-TPP/FA-50 as an ideal composite adsorbent for removal of textile dyes from the aqueous environment.
32534088	2	64	theme	FA	440:441	arg1	CS-TPP/FA-25					454:465	CS-TPP/FA-25	454:465	CS-TPP/FA-25	454:465	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	2	64	theme	FA	440:441	arg1	particles					443:451	25% FA particles	436:451	25% FA particles (CS-TPP/FA-25)	436:466	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	1	65	theme	RR120	393:397	arg1	dye					400:402	reactive orange 120 (RR120) dye	372:402	reactive orange 120 (RR120) dye	372:402	Chitosan (CS) was physically modified with fly ash (FA) powder and subjected to chemical cross-linking reaction with tripolyphosphate (TPP) to produce a cross-linked CS-TPP/FA composite as adsorbent for removal of reactive orange 120 (RR120) dye.
32534088	2	66	theme	%	438:438	arg1	CS-TPP/FA-25					454:465	CS-TPP/FA-25	454:465	CS-TPP/FA-25	454:465	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	2	66	theme	%	438:438	arg1	particles					443:451	25% FA particles	436:451	25% FA particles (CS-TPP/FA-25)	436:466	Different ratios of FA such as 25% FA particles (CS-TPP/FA-25) and 50% FA particles (CS-TPP/FA-50) were loaded into the molecular structure of CS-TPP.
32534088	5	67	theme	pH 4	996:999	arg1	solution					984:991	solution	984:991	solution of pH 4	984:999	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	67	theme	pH 4	996:999	arg1	time					1028:1031	time	1028:1031	time of 60 min	1028:1041	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	67	theme	pH 4	996:999	arg1	CS-TPP/FA-50					940:951	CS-TPP/FA-50	940:951	CS-TPP/FA-50 at adsorbent dosage of 0.07 g	940:981	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	5	67	theme	pH 4	996:999	arg1	temperature					1002:1012	temperature	1002:1012	temperature of 45 °C	1002:1021	Results revealed that the highest removal (88.8%) of RR120 dye was achieved by CS-TPP/FA-50 at adsorbent dosage of 0.07 g, solution of pH 4, temperature of 45 °C, and time of 60 min.
32534088	3	68	theme	dye	698:700	arg1	synthesis					643:651	the synthesis	639:651	the synthesis of the adsorbent	639:668	Box-Behnken design (BBD) was applied to optimize the input variables that affected the synthesis of the adsorbent and the adsorption of RR120 dye.
32534088	3	68	theme	dye	698:700	arg1	adsorption					678:687	the adsorption	674:687	the adsorption of RR120 dye	674:700	Box-Behnken design (BBD) was applied to optimize the input variables that affected the synthesis of the adsorbent and the adsorption of RR120 dye.
33250232	0	0	theme	acid	72:75	arg1	Brønsted					13:20	Brønsted	13:20	Brønsted	13:20	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.
33250232	0	0	theme	acid	72:75	arg1	acidity					32:38	Lewis acidity	26:38	Lewis acidity	26:38	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.
33250232	4	1	theme	strong	681:686	arg1	sites					693:697	strong acid sites	681:697	strong acid sites	681:697	Besides, the existence of medium-weak and strong acid sites, according to Brønsted and Lewis acidity, in Al-MCM-41 acids was confirmed by NH3-TPD and FTIR-pyridine adsorption.
33250232	4	2	theme	sites	693:697	arg1	existence					652:660	the existence	648:660	the existence	648:660	Besides, the existence of medium-weak and strong acid sites, according to Brønsted and Lewis acidity, in Al-MCM-41 acids was confirmed by NH3-TPD and FTIR-pyridine adsorption.
33250232	6	3	theme	cellulose	1015:1023	arg1	conversion					1025:1034	cellulose conversion	1015:1034	cellulose conversion	1015:1034	We also discovered that 5-HMF production, as well as cellulose conversion, strongly depended on the total acid, strong/medium-weak acid ratio, as well as Brønsted/Lewis acid ratio.
33250232	1	4	theme	solid	166:170	arg1	catalyst					294:301	a suitable catalyst	283:301	a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF)	283:367	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	1	4	theme	solid	166:170	arg1	acids					172:176	The modified Al-MCM-41 solid acids	143:176	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio	143:207	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	0	5	theme	solid	66:70	arg1	acid					72:75	the modified Al-MCM-41 solid acid	43:75	the modified Al-MCM-41 solid acid	43:75	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.
33250232	1	6	with	acids	172:176	arg1	ratio					203:207	turning Si/Al molar ratio	183:207	turning Si/Al molar ratio	183:207	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	6	7	theme	acid	1068:1071	arg1	ratio					1098:1102	the total acid, strong/medium-weak acid ratio	1058:1102	ratio	1098:1102	We also discovered that 5-HMF production, as well as cellulose conversion, strongly depended on the total acid, strong/medium-weak acid ratio, as well as Brønsted/Lewis acid ratio.
33250232	4	8	theme	acid	688:691	arg1	sites					693:697	strong acid sites	681:697	strong acid sites	681:697	Besides, the existence of medium-weak and strong acid sites, according to Brønsted and Lewis acidity, in Al-MCM-41 acids was confirmed by NH3-TPD and FTIR-pyridine adsorption.
33250232	0	9	theme	cellulose	80:88	arg1	conversion					90:99	cellulose conversion	80:99	cellulose conversion	80:99	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.
33250232	0	10	from	Influence	0:8	arg1	conversion					90:99	cellulose conversion	80:99	cellulose conversion	80:99	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.
33250232	0	10	from	Influence	0:8	arg1	selectivity					130:140	5-hydroxylmethylfurfuran selectivity	105:140	5-hydroxylmethylfurfuran selectivity	105:140	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.
33250232	4	11	theme	Al-MCM-41	744:752	arg1	acids					754:758	Al-MCM-41 acids	744:758	Al-MCM-41 acids	744:758	Besides, the existence of medium-weak and strong acid sites, according to Brønsted and Lewis acidity, in Al-MCM-41 acids was confirmed by NH3-TPD and FTIR-pyridine adsorption.
33250232	6	12	theme	Brønsted/Lewis	1116:1129	arg1	ratio					1136:1140	Brønsted/Lewis acid ratio	1116:1140	Brønsted/Lewis acid ratio	1116:1140	We also discovered that 5-HMF production, as well as cellulose conversion, strongly depended on the total acid, strong/medium-weak acid ratio, as well as Brønsted/Lewis acid ratio.
33250232	3	13	theme	29Si-MAS	550:557	arg1	results					563:569	The 27Al MAS NMR and 29Si-MAS NMR results	529:569	results	563:569	The 27Al MAS NMR and 29Si-MAS NMR results revealed the existence of both Al framework and Al extra framework.
33250232	2	14	theme	crystal	374:380	arg1	structure					382:390	crystal structure	374:390	crystal structure	374:390	The crystal structure, composition, morphologies and porosity of as-synthesized acids were characterized by XRD, FT-IR, N2 adsorption-desorption, TEM and EDS.
33250232	7	15	theme	solid	1231:1235	arg1	acid					1237:1240	solid acid	1231:1240	solid acid for 5-HMF production	1231:1261	Therefore, these parameters have been considered as essential factors for the design of solid acid for 5-HMF production.
33250232	6	16	theme	total	1062:1066	arg1	ratio					1098:1102	the total acid, strong/medium-weak acid ratio	1058:1102	ratio	1098:1102	We also discovered that 5-HMF production, as well as cellulose conversion, strongly depended on the total acid, strong/medium-weak acid ratio, as well as Brønsted/Lewis acid ratio.
33250232	5	17	theme	solid	831:835	arg1	acid					837:840	The 30Al-MCM-41 solid acid	815:840	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30)	815:865	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	5	17	theme	solid	831:835	arg1	ratio = 30					855:864	Si/Al molar ratio = 30	843:864	Si/Al molar ratio = 30	843:864	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	3	18	theme	MAS	538:540	arg1	NMR					542:544	The 27Al MAS NMR and 29Si-MAS NMR results	529:569	NMR	542:544	The 27Al MAS NMR and 29Si-MAS NMR results revealed the existence of both Al framework and Al extra framework.
33250232	4	19	theme	medium-weak	665:675	arg1	existence					652:660	the existence	648:660	the existence	648:660	Besides, the existence of medium-weak and strong acid sites, according to Brønsted and Lewis acidity, in Al-MCM-41 acids was confirmed by NH3-TPD and FTIR-pyridine adsorption.
33250232	5	20	theme	Si/Al	843:847	arg1	acid					837:840	The 30Al-MCM-41 solid acid	815:840	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30)	815:865	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	5	20	theme	Si/Al	843:847	arg1	ratio = 30					855:864	Si/Al molar ratio = 30	843:864	Si/Al molar ratio = 30	843:864	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	2	21	theme	N2	490:491	arg1	adsorption-desorption					493:513	N2 adsorption-desorption	490:513	N2 adsorption-desorption	490:513	The crystal structure, composition, morphologies and porosity of as-synthesized acids were characterized by XRD, FT-IR, N2 adsorption-desorption, TEM and EDS.
33250232	2	22	dep	structure	382:390	arg1	The					370:372	The	370:372	The	370:372	The crystal structure, composition, morphologies and porosity of as-synthesized acids were characterized by XRD, FT-IR, N2 adsorption-desorption, TEM and EDS.
33250232	4	23	from	existence	652:660	arg1	acids					754:758	Al-MCM-41 acids	744:758	Al-MCM-41 acids	744:758	Besides, the existence of medium-weak and strong acid sites, according to Brønsted and Lewis acidity, in Al-MCM-41 acids was confirmed by NH3-TPD and FTIR-pyridine adsorption.
33250232	1	24	theme	turning	183:189	arg1	ratio					203:207	turning Si/Al molar ratio	183:207	turning Si/Al molar ratio	183:207	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	4	25	theme	Lewis	726:730	arg1	acidity					732:738	Lewis acidity	726:738	Lewis acidity	726:738	Besides, the existence of medium-weak and strong acid sites, according to Brønsted and Lewis acidity, in Al-MCM-41 acids was confirmed by NH3-TPD and FTIR-pyridine adsorption.
33250232	1	26	theme	Si/Al	191:195	arg1	ratio					203:207	turning Si/Al molar ratio	183:207	turning Si/Al molar ratio	183:207	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	1	27	theme	suitable	285:292	arg1	catalyst					294:301	a suitable catalyst	283:301	a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF)	283:367	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	1	27	theme	suitable	285:292	arg1	acids					172:176	The modified Al-MCM-41 solid acids	143:176	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio	143:207	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	1	28	from	catalyst	294:301	arg1	conversion					320:329	the cellulose conversion	306:329	the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF)	306:367	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	5	29	theme	molar	849:853	arg1	acid					837:840	The 30Al-MCM-41 solid acid	815:840	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30)	815:865	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	5	29	theme	molar	849:853	arg1	ratio = 30					855:864	Si/Al molar ratio = 30	843:864	Si/Al molar ratio = 30	843:864	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	1	30	theme	molar	197:201	arg1	ratio					203:207	turning Si/Al molar ratio	183:207	turning Si/Al molar ratio	183:207	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	3	31	theme	NMR	559:561	arg1	results					563:569	The 27Al MAS NMR and 29Si-MAS NMR results	529:569	results	563:569	The 27Al MAS NMR and 29Si-MAS NMR results revealed the existence of both Al framework and Al extra framework.
33250232	2	32	theme	acids	450:454	arg1	morphologies					406:417	morphologies	406:417	morphologies	406:417	The crystal structure, composition, morphologies and porosity of as-synthesized acids were characterized by XRD, FT-IR, N2 adsorption-desorption, TEM and EDS.
33250232	2	32	theme	acids	450:454	arg1	composition					393:403	composition	393:403	composition	393:403	The crystal structure, composition, morphologies and porosity of as-synthesized acids were characterized by XRD, FT-IR, N2 adsorption-desorption, TEM and EDS.
33250232	2	32	theme	acids	450:454	arg1	structure					382:390	crystal structure	374:390	crystal structure	374:390	The crystal structure, composition, morphologies and porosity of as-synthesized acids were characterized by XRD, FT-IR, N2 adsorption-desorption, TEM and EDS.
33250232	2	32	theme	acids	450:454	arg1	porosity					423:430	porosity	423:430	porosity	423:430	The crystal structure, composition, morphologies and porosity of as-synthesized acids were characterized by XRD, FT-IR, N2 adsorption-desorption, TEM and EDS.
33250232	0	33	theme	Brønsted	13:20	arg1	Influence					0:8	Influence	0:8	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.	0:141	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.
33250232	0	34	theme	5-hydroxylmethylfurfuran	105:128	arg1	selectivity					130:140	5-hydroxylmethylfurfuran selectivity	105:140	5-hydroxylmethylfurfuran selectivity	105:140	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.
33250232	2	35	theme	as-synthesized	435:448	arg1	acids					450:454	as-synthesized acids	435:454	as-synthesized acids	435:454	The crystal structure, composition, morphologies and porosity of as-synthesized acids were characterized by XRD, FT-IR, N2 adsorption-desorption, TEM and EDS.
33250232	0	36	theme	acidity	32:38	arg1	Influence					0:8	Influence	0:8	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.	0:141	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.
33250232	5	37	theme	highest	905:911	arg1	yield					919:923	the highest 5-HMF yield	901:923	the highest 5-HMF yield of 40.56%	901:933	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	7	38	theme	5-HMF	1246:1250	arg1	production					1252:1261	5-HMF production	1246:1261	5-HMF production	1246:1261	Therefore, these parameters have been considered as essential factors for the design of solid acid for 5-HMF production.
33250232	0	39	theme	Lewis	26:30	arg1	acidity					32:38	Lewis acidity	26:38	Lewis acidity	26:38	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.
33250232	1	40	theme	cellulose	310:318	arg1	conversion					320:329	the cellulose conversion	306:329	the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF)	306:367	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	1	41	used	utilized	271:278	arg2	acids					172:176	The modified Al-MCM-41 solid acids	143:176	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio	143:207	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	1	41	used	utilized	271:278	arg2	catalyst					294:301	a suitable catalyst	283:301	a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF)	283:367	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	3	42	theme	Al	602:603	arg1	framework					605:613	Al framework	602:613	Al framework	602:613	The 27Al MAS NMR and 29Si-MAS NMR results revealed the existence of both Al framework and Al extra framework.
33250232	5	43	dep	exhibited	867:875	arg1	compared					935:942	compared	935:942	compared to other samples	935:959	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	7	44	theme	essential	1195:1203	arg1	parameters					1160:1169	these parameters	1154:1169	these parameters	1154:1169	Therefore, these parameters have been considered as essential factors for the design of solid acid for 5-HMF production.
33250232	7	44	theme	essential	1195:1203	arg1	factors					1205:1211	essential factors	1195:1211	essential factors for the design of solid acid for 5-HMF production	1195:1261	Therefore, these parameters have been considered as essential factors for the design of solid acid for 5-HMF production.
33250232	5	45	theme	other	947:951	arg1	samples					953:959	other samples	947:959	other samples	947:959	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	7	46	theme	acid	1237:1240	arg1	design					1221:1226	the design	1217:1226	the design of solid acid for 5-HMF production	1217:1261	Therefore, these parameters have been considered as essential factors for the design of solid acid for 5-HMF production.
33250232	3	47	theme	framework	628:636	arg1	existence					584:592	the existence	580:592	the existence of both Al framework and Al extra framework	580:636	The 27Al MAS NMR and 29Si-MAS NMR results revealed the existence of both Al framework and Al extra framework.
33250232	3	48	theme	Al	619:620	arg1	framework					628:636	Al extra framework	619:636	Al extra framework	619:636	The 27Al MAS NMR and 29Si-MAS NMR results revealed the existence of both Al framework and Al extra framework.
33250232	5	49	theme	5-HMF	913:917	arg1	yield					919:923	the highest 5-HMF yield	901:923	the highest 5-HMF yield of 40.56%	901:933	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	5	50	theme	%	933:933	arg1	yield					919:923	the highest 5-HMF yield	901:923	the highest 5-HMF yield of 40.56%	901:933	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	6	51	theme	acid	1131:1134	arg1	ratio					1136:1140	Brønsted/Lewis acid ratio	1116:1140	Brønsted/Lewis acid ratio	1116:1140	We also discovered that 5-HMF production, as well as cellulose conversion, strongly depended on the total acid, strong/medium-weak acid ratio, as well as Brønsted/Lewis acid ratio.
33250232	3	52	theme	extra	622:626	arg1	framework					628:636	Al extra framework	619:636	Al extra framework	619:636	The 27Al MAS NMR and 29Si-MAS NMR results revealed the existence of both Al framework and Al extra framework.
33250232	3	53	theme	27Al	533:536	arg1	NMR					542:544	The 27Al MAS NMR and 29Si-MAS NMR results	529:569	NMR	542:544	The 27Al MAS NMR and 29Si-MAS NMR results revealed the existence of both Al framework and Al extra framework.
33250232	6	54	theme	acid	1093:1096	arg1	ratio					1098:1102	the total acid, strong/medium-weak acid ratio	1058:1102	ratio	1098:1102	We also discovered that 5-HMF production, as well as cellulose conversion, strongly depended on the total acid, strong/medium-weak acid ratio, as well as Brønsted/Lewis acid ratio.
33250232	0	55	theme	Al-MCM-41	56:64	arg1	acid					72:75	the modified Al-MCM-41 solid acid	43:75	the modified Al-MCM-41 solid acid	43:75	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.
33250232	5	56	theme	excellent	877:885	arg1	activity					887:894	excellent activity	877:894	excellent activity	877:894	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	3	57	theme	framework	605:613	arg1	existence					584:592	the existence	580:592	the existence of both Al framework and Al extra framework	580:636	The 27Al MAS NMR and 29Si-MAS NMR results revealed the existence of both Al framework and Al extra framework.
33250232	5	58	theme	30Al-MCM-41	819:829	arg1	acid					837:840	The 30Al-MCM-41 solid acid	815:840	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30)	815:865	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	5	58	theme	30Al-MCM-41	819:829	arg1	ratio = 30					855:864	Si/Al molar ratio = 30	843:864	Si/Al molar ratio = 30	843:864	The 30Al-MCM-41 solid acid (Si/Al molar ratio = 30) exhibited excellent activity with the highest 5-HMF yield of 40.56% compared to other samples.
33250232	1	59	theme	modified	147:154	arg1	catalyst					294:301	a suitable catalyst	283:301	a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF)	283:367	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	1	59	theme	modified	147:154	arg1	acids					172:176	The modified Al-MCM-41 solid acids	143:176	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio	143:207	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	4	60	dep	NH3-TPD	777:783	arg1	adsorption					803:812	adsorption	803:812	adsorption	803:812	Besides, the existence of medium-weak and strong acid sites, according to Brønsted and Lewis acidity, in Al-MCM-41 acids was confirmed by NH3-TPD and FTIR-pyridine adsorption.
33250232	1	61	theme	hydrothermal	248:259	arg1	route					261:265	a hydrothermal route	246:265	a hydrothermal route	246:265	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	0	62	theme	modified	47:54	arg1	acid					72:75	the modified Al-MCM-41 solid acid	43:75	the modified Al-MCM-41 solid acid	43:75	Influence of Brønsted and Lewis acidity of the modified Al-MCM-41 solid acid on cellulose conversion and 5-hydroxylmethylfurfuran selectivity.
33250232	6	63	dep	ratio	1098:1102	arg1	strong/medium-weak					1074:1091	the total acid, strong/medium-weak acid ratio	1058:1102	strong/medium-weak	1074:1091	We also discovered that 5-HMF production, as well as cellulose conversion, strongly depended on the total acid, strong/medium-weak acid ratio, as well as Brønsted/Lewis acid ratio.
33250232	1	64	theme	Al-MCM-41	156:164	arg1	catalyst					294:301	a suitable catalyst	283:301	a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF)	283:367	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	1	64	theme	Al-MCM-41	156:164	arg1	acids					172:176	The modified Al-MCM-41 solid acids	143:176	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio	143:207	The modified Al-MCM-41 solid acids with turning Si/Al molar ratio were successfully fabricated through a hydrothermal route and utilized as a suitable catalyst in the cellulose conversion into 5-hydroxylmethylfurfural (5-HMF).
33250232	6	65	theme	5-HMF	986:990	arg1	production					992:1001	5-HMF production	986:1001	5-HMF production	986:1001	We also discovered that 5-HMF production, as well as cellulose conversion, strongly depended on the total acid, strong/medium-weak acid ratio, as well as Brønsted/Lewis acid ratio.
32475578	0	0	theme	mechanical	68:77	arg1	performance					79:89	improved mechanical performance	59:89	improved mechanical performance	59:89	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.
32475578	2	1	theme	improved	451:458	arg1	performance					471:481	improved mechanical performance	451:481	improved mechanical performance	451:481	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	2	2	theme	glycol	351:356	arg1	mPEG					376:379	mPEG	376:379	mPEG	376:379	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	2	2	theme	glycol	351:356	arg1	CS-g-mPEG					383:391	CS-g-mPEG	383:391	CS-g-mPEG	383:391	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	2	2	theme	glycol	351:356	arg1	ether					369:373	polyethylene glycol monomethyl ether	338:373	chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber	316:398	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	0	3	theme	improved	59:66	arg1	performance					79:89	improved mechanical performance	59:89	improved mechanical performance	59:89	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.
32475578	3	4	theme	CS	650:651	arg1	fiber					653:657	CS fiber	650:657	CS fiber	650:657	The tensile strength of CS-g-mPEG fiber reached 1.36 cN/dtex, increased by more than 50 % contrasted with CS fiber, due to the enhancement of molecular entanglement and hydrogen bonding interactions.
32475578	1	5	theme	sustainable	160:170	arg1	polymers					172:179	Nowadays, environment-friendly and sustainable polymers	125:179	polymers	172:179	Nowadays, environment-friendly and sustainable polymers have aroused great research attention, due to serious pollution caused by nondegradable and nonrenewable polymer waste.
32475578	1	6	theme	nondegradable	255:267	arg1	waste					294:298	nondegradable and nonrenewable polymer waste	255:298	nondegradable and nonrenewable polymer waste	255:298	Nowadays, environment-friendly and sustainable polymers have aroused great research attention, due to serious pollution caused by nondegradable and nonrenewable polymer waste.
32475578	4	7	dep	temperature	890:900	arg1	feel					943:946	feel	943:946	will not feel too cold or heat	934:963	Particularly, CS-g-mPEG fiber with stable shape could actively absorb heat as ambient temperature above 46 °C, then would release heat as ambient temperature below 26 °C. So, the human body will not feel too cold or heat.
32475578	5	8	theme	smart	1112:1116	arg1	textiles					1118:1125	smart textiles	1112:1125	smart textiles	1112:1125	Thus, this work do not only give a continuous process of fabricating SSPC CS-g-mPEG fiber for industry, but also provides an important choice for smart textiles.
32475578	2	9	with	chitosan	316:323	arg1	performance					471:481	improved mechanical performance	451:481	improved mechanical performance	451:481	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	2	9	with	chitosan	316:323	arg1	behavior					438:445	solid-solid phase change (SSPC) behavior	406:445	solid-solid phase change (SSPC) behavior	406:445	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	4	10	with	fiber	768:772	arg1	shape					786:790	stable shape	779:790	stable shape	779:790	Particularly, CS-g-mPEG fiber with stable shape could actively absorb heat as ambient temperature above 46 °C, then would release heat as ambient temperature below 26 °C. So, the human body will not feel too cold or heat.
32475578	1	11	theme	nonrenewable	273:284	arg1	waste					294:298	nondegradable and nonrenewable polymer waste	255:298	nondegradable and nonrenewable polymer waste	255:298	Nowadays, environment-friendly and sustainable polymers have aroused great research attention, due to serious pollution caused by nondegradable and nonrenewable polymer waste.
32475578	0	12	theme	wet	103:105	arg1	process					116:122	in-situ wet spinning process	95:122	in-situ wet spinning process	95:122	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.
32475578	5	13	theme	continuous	1001:1010	arg1	process					1012:1018	a continuous process	999:1018	a continuous process of fabricating SSPC CS-g-mPEG fiber	999:1054	Thus, this work do not only give a continuous process of fabricating SSPC CS-g-mPEG fiber for industry, but also provides an important choice for smart textiles.
32475578	2	14	theme	wet	522:524	arg1	process					535:541	in-situ wet spinning process	514:541	in-situ wet spinning process	514:541	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	0	15	with	fiber	48:52	arg1	performance					79:89	improved mechanical performance	59:89	improved mechanical performance	59:89	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.
32475578	4	16	theme	stable	779:784	arg1	shape					786:790	stable shape	779:790	stable shape	779:790	Particularly, CS-g-mPEG fiber with stable shape could actively absorb heat as ambient temperature above 46 °C, then would release heat as ambient temperature below 26 °C. So, the human body will not feel too cold or heat.
32475578	0	17	theme	in-situ	95:101	arg1	process					116:122	in-situ wet spinning process	95:122	in-situ wet spinning process	95:122	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.
32475578	2	18	theme	phase	418:422	arg1	behavior					438:445	solid-solid phase change (SSPC) behavior	406:445	solid-solid phase change (SSPC) behavior	406:445	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	0	19	theme	solid	6:10	arg1	fiber					48:52	Solid solid phase change (SSPC) chitosan-g-mPEG fiber	0:52	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.	0:123	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.
32475578	4	20	theme	human	923:927	arg1	body					929:932	the human body	919:932	the human body	919:932	Particularly, CS-g-mPEG fiber with stable shape could actively absorb heat as ambient temperature above 46 °C, then would release heat as ambient temperature below 26 °C. So, the human body will not feel too cold or heat.
32475578	4	21	theme	ambient	822:828	arg1	temperature					830:840	ambient temperature	822:840	ambient temperature	822:840	Particularly, CS-g-mPEG fiber with stable shape could actively absorb heat as ambient temperature above 46 °C, then would release heat as ambient temperature below 26 °C. So, the human body will not feel too cold or heat.
32475578	1	22	theme	aroused	186:192	arg1	attention					209:217	aroused great research attention	186:217	aroused great research attention	186:217	Nowadays, environment-friendly and sustainable polymers have aroused great research attention, due to serious pollution caused by nondegradable and nonrenewable polymer waste.
32475578	0	23	theme	Solid	0:4	arg1	fiber					48:52	Solid solid phase change (SSPC) chitosan-g-mPEG fiber	0:52	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.	0:123	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.
32475578	1	24	theme	polymer	286:292	arg1	waste					294:298	nondegradable and nonrenewable polymer waste	255:298	nondegradable and nonrenewable polymer waste	255:298	Nowadays, environment-friendly and sustainable polymers have aroused great research attention, due to serious pollution caused by nondegradable and nonrenewable polymer waste.
32475578	3	25	theme	tensile	548:554	arg1	strength					556:563	The tensile strength	544:563	The tensile strength of CS-g-mPEG fiber	544:582	The tensile strength of CS-g-mPEG fiber reached 1.36 cN/dtex, increased by more than 50 % contrasted with CS fiber, due to the enhancement of molecular entanglement and hydrogen bonding interactions.
32475578	5	26	theme	CS-g-mPEG	1040:1048	arg1	fiber					1050:1054	fabricating SSPC CS-g-mPEG fiber	1023:1054	fabricating SSPC CS-g-mPEG fiber	1023:1054	Thus, this work do not only give a continuous process of fabricating SSPC CS-g-mPEG fiber for industry, but also provides an important choice for smart textiles.
32475578	1	27	theme	great	194:198	arg1	attention					209:217	aroused great research attention	186:217	aroused great research attention	186:217	Nowadays, environment-friendly and sustainable polymers have aroused great research attention, due to serious pollution caused by nondegradable and nonrenewable polymer waste.
32475578	0	28	theme	change	18:23	arg1	fiber					48:52	Solid solid phase change (SSPC) chitosan-g-mPEG fiber	0:52	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.	0:123	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.
32475578	3	29	theme	hydrogen	713:720	arg1	interactions					730:741	hydrogen bonding interactions	713:741	hydrogen bonding interactions	713:741	The tensile strength of CS-g-mPEG fiber reached 1.36 cN/dtex, increased by more than 50 % contrasted with CS fiber, due to the enhancement of molecular entanglement and hydrogen bonding interactions.
32475578	2	30	theme	spinning	526:533	arg1	process					535:541	in-situ wet spinning process	514:541	in-situ wet spinning process	514:541	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	1	31	theme	research	200:207	arg1	attention					209:217	aroused great research attention	186:217	aroused great research attention	186:217	Nowadays, environment-friendly and sustainable polymers have aroused great research attention, due to serious pollution caused by nondegradable and nonrenewable polymer waste.
32475578	0	32	theme	phase	12:16	arg1	fiber					48:52	Solid solid phase change (SSPC) chitosan-g-mPEG fiber	0:52	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.	0:123	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.
32475578	5	33	theme	SSPC	1035:1038	arg1	fiber					1050:1054	fabricating SSPC CS-g-mPEG fiber	1023:1054	fabricating SSPC CS-g-mPEG fiber	1023:1054	Thus, this work do not only give a continuous process of fabricating SSPC CS-g-mPEG fiber for industry, but also provides an important choice for smart textiles.
32475578	0	34	theme	spinning	107:114	arg1	process					116:122	in-situ wet spinning process	95:122	in-situ wet spinning process	95:122	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.
32475578	2	35	theme	polyethylene	338:349	arg1	mPEG					376:379	mPEG	376:379	mPEG	376:379	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	2	35	theme	polyethylene	338:349	arg1	CS-g-mPEG					383:391	CS-g-mPEG	383:391	CS-g-mPEG	383:391	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	2	35	theme	polyethylene	338:349	arg1	ether					369:373	polyethylene glycol monomethyl ether	338:373	chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber	316:398	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	2	36	theme	SSPC	432:435	arg1	behavior					438:445	solid-solid phase change (SSPC) behavior	406:445	solid-solid phase change (SSPC) behavior	406:445	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	0	37	theme	SSPC	26:29	arg1	fiber					48:52	Solid solid phase change (SSPC) chitosan-g-mPEG fiber	0:52	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.	0:123	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.
32475578	3	38	theme	entanglement	696:707	arg1	enhancement					671:681	the enhancement	667:681	the enhancement of molecular entanglement and hydrogen bonding interactions	667:741	The tensile strength of CS-g-mPEG fiber reached 1.36 cN/dtex, increased by more than 50 % contrasted with CS fiber, due to the enhancement of molecular entanglement and hydrogen bonding interactions.
32475578	2	39	theme	in-situ	514:520	arg1	process					535:541	in-situ wet spinning process	514:541	in-situ wet spinning process	514:541	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	3	40	theme	CS-g-mPEG	568:576	arg1	fiber					578:582	CS-g-mPEG fiber	568:582	CS-g-mPEG fiber	568:582	The tensile strength of CS-g-mPEG fiber reached 1.36 cN/dtex, increased by more than 50 % contrasted with CS fiber, due to the enhancement of molecular entanglement and hydrogen bonding interactions.
32475578	4	41	theme	ambient	882:888	arg1	temperature					890:900	ambient temperature	882:900	ambient temperature below 26 °C. So, the human body will not feel too cold or heat	882:963	Particularly, CS-g-mPEG fiber with stable shape could actively absorb heat as ambient temperature above 46 °C, then would release heat as ambient temperature below 26 °C. So, the human body will not feel too cold or heat.
32475578	1	42	contain	have	181:184	arg1	polymers					172:179	Nowadays, environment-friendly and sustainable polymers	125:179	polymers	172:179	Nowadays, environment-friendly and sustainable polymers have aroused great research attention, due to serious pollution caused by nondegradable and nonrenewable polymer waste.
32475578	1	42	contain	have	181:184	arg2	attention					209:217	aroused great research attention	186:217	aroused great research attention	186:217	Nowadays, environment-friendly and sustainable polymers have aroused great research attention, due to serious pollution caused by nondegradable and nonrenewable polymer waste.
32475578	2	43	theme	solid-solid	406:416	arg1	behavior					438:445	solid-solid phase change (SSPC) behavior	406:445	solid-solid phase change (SSPC) behavior	406:445	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	5	44	theme	important	1091:1099	arg1	choice					1101:1106	an important choice	1088:1106	an important choice	1088:1106	Thus, this work do not only give a continuous process of fabricating SSPC CS-g-mPEG fiber for industry, but also provides an important choice for smart textiles.
32475578	0	45	theme	chitosan-g-mPEG	32:46	arg1	fiber					48:52	Solid solid phase change (SSPC) chitosan-g-mPEG fiber	0:52	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.	0:123	Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.
32475578	2	46	theme	mechanical	460:469	arg1	performance					471:481	improved mechanical performance	451:481	improved mechanical performance	451:481	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	2	47	theme	grafted	330:336	arg1	fiber					394:398	grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber	330:398	chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber	316:398	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	2	48	theme	monomethyl	358:367	arg1	mPEG					376:379	mPEG	376:379	mPEG	376:379	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	2	48	theme	monomethyl	358:367	arg1	CS-g-mPEG					383:391	CS-g-mPEG	383:391	CS-g-mPEG	383:391	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	2	48	theme	monomethyl	358:367	arg1	ether					369:373	polyethylene glycol monomethyl ether	338:373	chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber	316:398	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	3	49	theme	bonding	722:728	arg1	interactions					730:741	hydrogen bonding interactions	713:741	hydrogen bonding interactions	713:741	The tensile strength of CS-g-mPEG fiber reached 1.36 cN/dtex, increased by more than 50 % contrasted with CS fiber, due to the enhancement of molecular entanglement and hydrogen bonding interactions.
32475578	3	50	theme	interactions	730:741	arg1	enhancement					671:681	the enhancement	667:681	the enhancement of molecular entanglement and hydrogen bonding interactions	667:741	The tensile strength of CS-g-mPEG fiber reached 1.36 cN/dtex, increased by more than 50 % contrasted with CS fiber, due to the enhancement of molecular entanglement and hydrogen bonding interactions.
32475578	4	51	theme	CS-g-mPEG	758:766	arg1	fiber					768:772	CS-g-mPEG fiber	758:772	CS-g-mPEG fiber with stable shape	758:790	Particularly, CS-g-mPEG fiber with stable shape could actively absorb heat as ambient temperature above 46 °C, then would release heat as ambient temperature below 26 °C. So, the human body will not feel too cold or heat.
32475578	3	52	theme	fiber	578:582	arg1	strength					556:563	The tensile strength	544:563	The tensile strength of CS-g-mPEG fiber	544:582	The tensile strength of CS-g-mPEG fiber reached 1.36 cN/dtex, increased by more than 50 % contrasted with CS fiber, due to the enhancement of molecular entanglement and hydrogen bonding interactions.
32475578	2	53	dep	chitosan	316:323	arg1	fiber					394:398	grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber	330:398	chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber	316:398	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	3	54	dep	increased	606:614	arg1	contrasted					634:643	contrasted	634:643	contrasted	634:643	The tensile strength of CS-g-mPEG fiber reached 1.36 cN/dtex, increased by more than 50 % contrasted with CS fiber, due to the enhancement of molecular entanglement and hydrogen bonding interactions.
32475578	1	55	theme	Nowadays	125:132	arg1	polymers					172:179	Nowadays, environment-friendly and sustainable polymers	125:179	polymers	172:179	Nowadays, environment-friendly and sustainable polymers have aroused great research attention, due to serious pollution caused by nondegradable and nonrenewable polymer waste.
32475578	1	56	theme	serious	227:233	arg1	pollution					235:243	serious pollution	227:243	serious pollution caused by nondegradable and nonrenewable polymer waste	227:298	Nowadays, environment-friendly and sustainable polymers have aroused great research attention, due to serious pollution caused by nondegradable and nonrenewable polymer waste.
32475578	5	57	theme	fiber	1050:1054	arg1	process					1012:1018	a continuous process	999:1018	a continuous process of fabricating SSPC CS-g-mPEG fiber	999:1054	Thus, this work do not only give a continuous process of fabricating SSPC CS-g-mPEG fiber for industry, but also provides an important choice for smart textiles.
32475578	3	58	dep	reached	584:590	arg1	increased					606:614	increased	606:614	increased by more than 50 % contrasted with CS fiber, due to the enhancement of molecular entanglement and hydrogen bonding interactions	606:741	The tensile strength of CS-g-mPEG fiber reached 1.36 cN/dtex, increased by more than 50 % contrasted with CS fiber, due to the enhancement of molecular entanglement and hydrogen bonding interactions.
32475578	2	59	theme	ether	369:373	arg1	fiber					394:398	grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber	330:398	chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber	316:398	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	2	60	theme	change	424:429	arg1	behavior					438:445	solid-solid phase change (SSPC) behavior	406:445	solid-solid phase change (SSPC) behavior	406:445	In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process.
32475578	5	61	theme	fabricating	1023:1033	arg1	fiber					1050:1054	fabricating SSPC CS-g-mPEG fiber	1023:1054	fabricating SSPC CS-g-mPEG fiber	1023:1054	Thus, this work do not only give a continuous process of fabricating SSPC CS-g-mPEG fiber for industry, but also provides an important choice for smart textiles.
32475578	4	62	dep	absorb	807:812	arg1	release					866:872	release	866:872	would release heat as ambient temperature below 26 °C. So, the human body will not feel too cold or heat	860:963	Particularly, CS-g-mPEG fiber with stable shape could actively absorb heat as ambient temperature above 46 °C, then would release heat as ambient temperature below 26 °C. So, the human body will not feel too cold or heat.
32475578	1	63	theme	environment-friendly	135:154	arg1	polymers					172:179	Nowadays, environment-friendly and sustainable polymers	125:179	polymers	172:179	Nowadays, environment-friendly and sustainable polymers have aroused great research attention, due to serious pollution caused by nondegradable and nonrenewable polymer waste.
34943784	0	0	theme	Inflammatory	108:119	arg1	Regulation					121:130	Inflammatory Regulation	108:130	Inflammatory Regulation	108:130	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells Neural Differentiation and Inflammatory Regulation.
34943784	3	1	theme	UV-Vis	748:753	arg1	measurements					734:745	contact angle measurements	720:745	contact angle measurements	720:745	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	3	1	theme	UV-Vis	748:753	arg1	spectra					755:761	UV-Vis spectra	748:761	UV-Vis spectra	748:761	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	2	2	dep	in	630:631	arg1	vivo					633:636	vivo	633:636	vivo	633:636	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	4	3	theme	platelet	958:965	arg1	activation					967:976	monocyte and platelet activation	945:976	activation	967:976	The biocompatibility results demonstrated Pul-Col-Au enhanced cell viability, promoted anti-oxidative ability for MSCs and HSFs, and inhibited monocyte and platelet activation.
34943784	3	4	theme	angle	728:732	arg1	SERS					778:781	SERS	778:781	SERS	778:781	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	3	4	theme	angle	728:732	arg1	measurements					734:745	contact angle measurements	720:745	contact angle measurements	720:745	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	3	4	theme	angle	728:732	arg1	spectra					755:761	UV-Vis spectra	748:761	UV-Vis spectra	748:761	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	3	4	theme	angle	728:732	arg1	spectra					769:775	FTIR spectra	764:775	FTIR spectra	764:775	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	7	5	theme	animal	1187:1192	arg1	models					1194:1199	Our animal models	1183:1199	Our animal models	1183:1199	Our animal models elucidated better biocompatibility, as well as the promotion of endothelialization after implanting Pul-Col-Au for a period of one month.
34943784	6	6	theme	neuronal	1137:1144	arg1	capacities					1162:1171	neuronal differentiation capacities	1137:1171	neuronal differentiation capacities for MSCs	1137:1180	Moreover, we evaluated the efficacy of Pul-Col-Au in the enhancement of neuronal differentiation capacities for MSCs.
34943784	8	7	theme	Au	1534:1535	arg1	nanoparticles					1537:1549	Au nanoparticles	1534:1549	Au nanoparticles	1534:1549	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	5	8	theme	MMP	1049:1051	arg1	activities					1053:1062	the MMP activities	1045:1062	the MMP activities	1045:1062	Pul-Col-Au also induced the lowest cell apoptosis and facilitated the MMP activities.
34943784	5	9	theme	cell	1014:1017	arg1	apoptosis					1019:1027	the lowest cell apoptosis	1003:1027	the lowest cell apoptosis	1003:1027	Pul-Col-Au also induced the lowest cell apoptosis and facilitated the MMP activities.
34943784	5	10	theme	lowest	1007:1012	arg1	apoptosis					1019:1027	the lowest cell apoptosis	1003:1027	the lowest cell apoptosis	1003:1027	Pul-Col-Au also induced the lowest cell apoptosis and facilitated the MMP activities.
34943784	2	11	theme	differentiation	549:563	arg1	capacities					565:574	differentiation capacities	549:574	differentiation capacities	549:574	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	3	12	theme	FTIR	764:767	arg1	measurements					734:745	contact angle measurements	720:745	contact angle measurements	720:745	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	3	12	theme	FTIR	764:767	arg1	spectra					769:775	FTIR spectra	764:775	FTIR spectra	764:775	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	2	13	theme	in	630:631	arg1	assessments					638:648	in vitro and in vivo assessments	617:648	in vitro and in vivo assessments	617:648	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	8	14	from	regeneration	1627:1638	arg1	treatments					1664:1673	any further clinical treatments	1643:1673	any further clinical treatments	1643:1673	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	6	15	theme	differentiation	1146:1160	arg1	capacities					1162:1171	neuronal differentiation capacities	1137:1171	neuronal differentiation capacities for MSCs	1137:1180	Moreover, we evaluated the efficacy of Pul-Col-Au in the enhancement of neuronal differentiation capacities for MSCs.
34943784	4	16	theme	anti-oxidative	889:902	arg1	ability					904:910	anti-oxidative ability	889:910	anti-oxidative ability for MSCs and HSFs	889:928	The biocompatibility results demonstrated Pul-Col-Au enhanced cell viability, promoted anti-oxidative ability for MSCs and HSFs, and inhibited monocyte and platelet activation.
34943784	8	17	theme	tissue	1620:1625	arg1	regeneration					1627:1638	skin tissue regeneration	1615:1638	skin tissue regeneration in any further clinical treatments	1615:1673	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	7	18	theme	better	1212:1217	arg1	biocompatibility					1219:1234	better biocompatibility	1212:1234	better biocompatibility	1212:1234	Our animal models elucidated better biocompatibility, as well as the promotion of endothelialization after implanting Pul-Col-Au for a period of one month.
34943784	6	19	from	efficacy	1092:1099	arg1	enhancement					1122:1132	the enhancement	1118:1132	the enhancement of neuronal differentiation capacities for MSCs	1118:1180	Moreover, we evaluated the efficacy of Pul-Col-Au in the enhancement of neuronal differentiation capacities for MSCs.
34943784	4	20	dep	demonstrated	831:842	arg1	promoted					880:887	promoted	880:887	promoted anti-oxidative ability for MSCs and HSFs	880:928	The biocompatibility results demonstrated Pul-Col-Au enhanced cell viability, promoted anti-oxidative ability for MSCs and HSFs, and inhibited monocyte and platelet activation.
34943784	4	20	dep	demonstrated	831:842	arg1	inhibited					935:943	inhibited	935:943	inhibited monocyte and platelet activation	935:976	The biocompatibility results demonstrated Pul-Col-Au enhanced cell viability, promoted anti-oxidative ability for MSCs and HSFs, and inhibited monocyte and platelet activation.
34943784	4	20	dep	demonstrated	831:842	arg1	enhanced					855:862	enhanced	855:862	enhanced cell viability	855:877	The biocompatibility results demonstrated Pul-Col-Au enhanced cell viability, promoted anti-oxidative ability for MSCs and HSFs, and inhibited monocyte and platelet activation.
34943784	0	21	theme	Pullulan-Collagen-Gold	11:32	arg1	Cells					75:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells Neural Differentiation and Inflammatory Regulation.
34943784	8	22	theme	skin	1615:1618	arg1	regeneration					1627:1638	skin tissue regeneration	1615:1638	skin tissue regeneration in any further clinical treatments	1615:1673	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	2	23	dep	in	617:618	arg1	vitro					620:624	vitro	620:624	vitro	620:624	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	0	24	theme	Engineered	0:9	arg1	Cells					75:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells Neural Differentiation and Inflammatory Regulation.
34943784	1	25	theme	damaged	317:323	arg1	tissues					325:331	damaged tissues	317:331	damaged tissues	317:331	Tissue repair engineering supported by nanoparticles and stem cells has been demonstrated as being an efficient strategy for promoting the healing potential during the regeneration of damaged tissues.
34943784	8	26	theme	anti-inflammatory	1445:1461	arg1	capacities					1463:1472	anti-inflammatory capacities	1445:1472	anti-inflammatory capacities	1445:1472	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	8	27	theme	pullulan	1510:1517	arg1	combination					1495:1505	the combination	1491:1505	the combination of pullulan, collagen, and Au nanoparticles	1491:1549	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	8	27	theme	pullulan	1510:1517	arg1	nanocomposites					1568:1581	potential nanocomposites	1558:1581	potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments	1558:1673	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	2	28	theme	pure	410:413	arg1	Col					415:417	pure Col	410:417	pure Col	410:417	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	0	29	theme	Composite	39:47	arg1	Cells					75:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells Neural Differentiation and Inflammatory Regulation.
34943784	1	30	theme	tissues	325:331	arg1	regeneration					301:312	the regeneration	297:312	the regeneration of damaged tissues	297:331	Tissue repair engineering supported by nanoparticles and stem cells has been demonstrated as being an efficient strategy for promoting the healing potential during the regeneration of damaged tissues.
34943784	1	31	theme	Tissue	133:138	arg1	engineering					147:157	Tissue repair engineering	133:157	Tissue repair engineering supported by nanoparticles and stem cells	133:199	Tissue repair engineering supported by nanoparticles and stem cells has been demonstrated as being an efficient strategy for promoting the healing potential during the regeneration of damaged tissues.
34943784	6	32	theme	Pul-Col-Au	1104:1113	arg1	efficacy					1092:1099	the efficacy	1088:1099	the efficacy of Pul-Col-Au in the enhancement of neuronal differentiation capacities for MSCs	1088:1180	Moreover, we evaluated the efficacy of Pul-Col-Au in the enhancement of neuronal differentiation capacities for MSCs.
34943784	0	33	theme	Nano	34:37	arg1	Cells					75:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells Neural Differentiation and Inflammatory Regulation.
34943784	8	34	theme	further	1647:1653	arg1	treatments					1664:1673	any further clinical treatments	1643:1673	any further clinical treatments	1643:1673	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	2	35	theme	anti-inflammatory	581:597	arg1	abilities					599:607	anti-inflammatory abilities	581:607	anti-inflammatory abilities	581:607	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	3	36	theme	SEM	704:706	arg1	assay					713:717	SEM, DLS assay	704:717	SEM, DLS assay	704:717	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	1	37	theme	repair	140:145	arg1	engineering					147:157	Tissue repair engineering	133:157	Tissue repair engineering supported by nanoparticles and stem cells	133:199	Tissue repair engineering supported by nanoparticles and stem cells has been demonstrated as being an efficient strategy for promoting the healing potential during the regeneration of damaged tissues.
34943784	1	38	theme	efficient	235:243	arg1	strategy					245:252	an efficient strategy	232:252	an efficient strategy for promoting the healing potential during the regeneration of damaged tissues	232:331	Tissue repair engineering supported by nanoparticles and stem cells has been demonstrated as being an efficient strategy for promoting the healing potential during the regeneration of damaged tissues.
34943784	0	39	theme	Mesenchymal	58:68	arg1	Cells					75:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells Neural Differentiation and Inflammatory Regulation.
34943784	2	40	theme	current	341:347	arg1	study					349:353	the current study	337:353	the current study	337:353	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	4	41	theme	cell	864:867	arg1	viability					869:877	cell viability	864:877	cell viability	864:877	The biocompatibility results demonstrated Pul-Col-Au enhanced cell viability, promoted anti-oxidative ability for MSCs and HSFs, and inhibited monocyte and platelet activation.
34943784	8	42	theme	above	1343:1347	arg1	evidence					1349:1356	The above evidence	1339:1356	The above evidence	1339:1356	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	0	43	theme	Improves	49:56	arg1	Cells					75:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells Neural Differentiation and Inflammatory Regulation.
34943784	2	44	theme	physicochemical	481:495	arg1	properties					497:506	their physicochemical properties	475:506	their physicochemical properties	475:506	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	8	45	from	repair	1596:1601	arg1	treatments					1664:1673	any further clinical treatments	1643:1673	any further clinical treatments	1643:1673	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	8	46	theme	clinical	1655:1662	arg1	treatments					1664:1673	any further clinical treatments	1643:1673	any further clinical treatments	1643:1673	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	8	47	theme	differentiation	1424:1438	arg1	capacities					1463:1472	anti-inflammatory capacities	1445:1472	anti-inflammatory capacities	1445:1472	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	8	47	theme	differentiation	1424:1438	arg1	enhancement					1400:1410	enhancement	1400:1410	enhancement of neuronal differentiation	1400:1438	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	8	47	theme	differentiation	1424:1438	arg1	biocompatibility					1382:1397	the excellent biocompatibility	1368:1397	the excellent biocompatibility	1368:1397	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	8	48	theme	nanoparticles	1537:1549	arg1	combination					1495:1505	the combination	1491:1505	the combination of pullulan, collagen, and Au nanoparticles	1491:1549	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	8	48	theme	nanoparticles	1537:1549	arg1	nanocomposites					1568:1581	potential nanocomposites	1558:1581	potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments	1558:1673	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	8	49	theme	neuronal	1587:1594	arg1	repair					1596:1601	neuronal repair	1587:1601	neuronal repair	1587:1601	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	0	50	theme	Stem	70:73	arg1	Cells					75:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells Neural Differentiation and Inflammatory Regulation.
34943784	3	51	theme	XPS	788:790	arg1	analysis					792:799	XPS analysis	788:799	XPS analysis	788:799	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	8	52	theme	potential	1558:1566	arg1	combination					1495:1505	the combination	1491:1505	the combination of pullulan, collagen, and Au nanoparticles	1491:1549	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	8	52	theme	potential	1558:1566	arg1	nanocomposites					1568:1581	potential nanocomposites	1558:1581	potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments	1558:1673	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	2	53	theme	various	368:374	arg1	Col-Au					453:458	Col-Au	453:458	Col-Au	453:458	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	2	53	theme	various	368:374	arg1	Pul					405:407	Pul	405:407	Pul	405:407	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	2	53	theme	various	368:374	arg1	Pul-Au					429:434	Pul-Au	429:434	Pul-Au	429:434	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	2	53	theme	various	368:374	arg1	Pul-Col-Au					437:446	Pul-Col-Au	437:446	Pul-Col-Au	437:446	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	2	53	theme	various	368:374	arg1	nanomaterials					376:388	various nanomaterials	368:388	various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au	368:458	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	2	53	theme	various	368:374	arg1	Col					415:417	pure Col	410:417	pure Col	410:417	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	8	54	theme	collagen	1520:1527	arg1	combination					1495:1505	the combination	1491:1505	the combination of pullulan, collagen, and Au nanoparticles	1491:1549	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	8	54	theme	collagen	1520:1527	arg1	nanocomposites					1568:1581	potential nanocomposites	1558:1581	potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments	1558:1673	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	2	55	theme	in	617:618	arg1	assessments					638:648	in vitro and in vivo assessments	617:648	in vitro and in vivo assessments	617:648	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	3	56	theme	contact	720:726	arg1	SERS					778:781	SERS	778:781	SERS	778:781	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	3	56	theme	contact	720:726	arg1	measurements					734:745	contact angle measurements	720:745	contact angle measurements	720:745	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	3	56	theme	contact	720:726	arg1	spectra					755:761	UV-Vis spectra	748:761	UV-Vis spectra	748:761	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	3	56	theme	contact	720:726	arg1	spectra					769:775	FTIR spectra	764:775	FTIR spectra	764:775	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	7	57	theme	month	1332:1336	arg1	period					1318:1323	a period	1316:1323	a period of one month	1316:1336	Our animal models elucidated better biocompatibility, as well as the promotion of endothelialization after implanting Pul-Col-Au for a period of one month.
34943784	0	58	dep	Differentiation	88:102	arg1	Cells					75:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells	0:79	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells Neural Differentiation and Inflammatory Regulation.
34943784	4	59	theme	monocyte	945:952	arg1	activation					967:976	monocyte and platelet activation	945:976	activation	967:976	The biocompatibility results demonstrated Pul-Col-Au enhanced cell viability, promoted anti-oxidative ability for MSCs and HSFs, and inhibited monocyte and platelet activation.
34943784	4	60	theme	biocompatibility	806:821	arg1	results					823:829	The biocompatibility results	802:829	The biocompatibility results	802:829	The biocompatibility results demonstrated Pul-Col-Au enhanced cell viability, promoted anti-oxidative ability for MSCs and HSFs, and inhibited monocyte and platelet activation.
34943784	6	61	theme	capacities	1162:1171	arg1	enhancement					1122:1132	the enhancement	1118:1132	the enhancement of neuronal differentiation capacities for MSCs	1118:1180	Moreover, we evaluated the efficacy of Pul-Col-Au in the enhancement of neuronal differentiation capacities for MSCs.
34943784	8	62	theme	neuronal	1415:1422	arg1	differentiation					1424:1438	neuronal differentiation	1415:1438	neuronal differentiation	1415:1438	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	8	63	theme	excellent	1372:1380	arg1	biocompatibility					1382:1397	the excellent biocompatibility	1368:1397	the excellent biocompatibility	1368:1397	The above evidence indicates the excellent biocompatibility, enhancement of neuronal differentiation, and anti-inflammatory capacities, suggesting that the combination of pullulan, collagen, and Au nanoparticles can be potential nanocomposites for neuronal repair, as well as skin tissue regeneration in any further clinical treatments.
34943784	2	64	theme	biological	527:536	arg1	functions					538:546	biological functions	527:546	biological functions	527:546	In the current study, we prepared various nanomaterials including pure Pul, pure Col, Pul-Col, Pul-Au, Pul-Col-Au, and Col-Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, and anti-inflammatory abilities through in vitro and in vivo assessments.
34943784	1	65	theme	healing	272:278	arg1	potential					280:288	the healing potential	268:288	the healing potential	268:288	Tissue repair engineering supported by nanoparticles and stem cells has been demonstrated as being an efficient strategy for promoting the healing potential during the regeneration of damaged tissues.
34943784	0	66	theme	Neural	81:86	arg1	Differentiation					88:102	Neural Differentiation	81:102	Neural Differentiation	81:102	Engineered Pullulan-Collagen-Gold Nano Composite Improves Mesenchymal Stem Cells Neural Differentiation and Inflammatory Regulation.
34943784	3	67	theme	physicochemical	655:669	arg1	properties					671:680	The physicochemical properties	651:680	The physicochemical properties	651:680	The physicochemical properties were characterized by SEM, DLS assay, contact angle measurements, UV-Vis spectra, FTIR spectra, SERS, and XPS analysis.
34943784	1	68	theme	stem	190:193	arg1	cells					195:199	stem cells	190:199	stem cells	190:199	Tissue repair engineering supported by nanoparticles and stem cells has been demonstrated as being an efficient strategy for promoting the healing potential during the regeneration of damaged tissues.
34943784	7	69	theme	endothelialization	1265:1282	arg1	biocompatibility					1219:1234	better biocompatibility	1212:1234	better biocompatibility	1212:1234	Our animal models elucidated better biocompatibility, as well as the promotion of endothelialization after implanting Pul-Col-Au for a period of one month.
34943784	7	69	theme	endothelialization	1265:1282	arg1	promotion					1252:1260	the promotion	1248:1260	the promotion of endothelialization	1248:1282	Our animal models elucidated better biocompatibility, as well as the promotion of endothelialization after implanting Pul-Col-Au for a period of one month.
32382944	3	0	theme	207.3 g/L	885:893	arg1	CSL					895:897	207.3 g/L CSL	885:897	207.3 g/L CSL	885:897	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	1	1	theme	amylolytic	375:384	arg1	acid					393:396	amylolytic lactic acid	375:396	amylolytic lactic acid bacterium	375:406	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	7	2	theme	starchy	1568:1574	arg1	valorization					1582:1593	industrial starchy waste valorization	1557:1593	industrial starchy waste valorization	1557:1593	Not only showing the feasible bioconversion process for GSW utilizing as a substrate for L(+)-LA production, this research also demonstrated the efficient model for industrial starchy waste valorization.
32382944	1	3	theme	acid	393:396	arg1	bacterium					398:406	amylolytic lactic acid bacterium	375:406	amylolytic lactic acid bacterium	375:406	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	1	3	theme	acid	393:396	arg1	K-1					430:432	Enterococcus faecium K-1	409:432	Enterococcus faecium K-1	409:432	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	6	4	theme	-LA	1334:1336	arg1	productivity					1338:1349	L(+)-LA productivity	1330:1349	L(+)-LA productivity	1330:1349	Thinning GSW with α-amylase from Lactobacillus plantarum S21 increased L(+)-LA productivity in the early stage of 24-h fermentation.
32382944	1	5	theme	starchy	249:255	arg1	GSW					264:266	GSW	264:266	GSW	264:266	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	1	5	theme	starchy	249:255	arg1	waste					257:261	gelatinized starchy waste	237:261	gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis,	237:350	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	2	6	theme	suitable	574:581	arg1	liquor					548:553	corn steep liquor	537:553	corn steep liquor (CSL)	537:559	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	2	6	theme	suitable	574:581	arg1	property					644:651	the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property	565:651	the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property	565:651	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	7	7	theme	efficient	1537:1545	arg1	model					1547:1551	the efficient model	1533:1551	the efficient model for industrial starchy waste valorization	1533:1593	Not only showing the feasible bioconversion process for GSW utilizing as a substrate for L(+)-LA production, this research also demonstrated the efficient model for industrial starchy waste valorization.
32382944	3	8	theme	experimental	688:699	arg1	design					701:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	8	theme	experimental	688:699	arg1	design					725:730	Plackett-Burman design	709:730	Plackett-Burman design incorporated with central composite design (CCD)	709:779	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	8	theme	experimental	688:699	arg1	-LA					808:810	predicted the maximum L(+)-LA	782:810	predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80	782:981	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	6	9	theme	L	1330:1330	arg1	productivity					1338:1349	L(+)-LA productivity	1330:1349	L(+)-LA productivity	1330:1349	Thinning GSW with α-amylase from Lactobacillus plantarum S21 increased L(+)-LA productivity in the early stage of 24-h fermentation.
32382944	5	10	theme	10-L	1223:1226	arg1	fermenter					1228:1236	a 10-L fermenter	1221:1236	a 10-L fermenter	1221:1236	Fermentation using the optimized medium without minerals (OM-Mi) containing only GSW (125.7 g/L) and CSL (207.3 g/L) in a 10-L fermenter was also successful.
32382944	3	11	theme	applying	669:676	arg1	design					701:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	11	theme	applying	669:676	arg1	design					725:730	Plackett-Burman design	709:730	Plackett-Burman design incorporated with central composite design (CCD)	709:779	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	11	theme	applying	669:676	arg1	-LA					808:810	predicted the maximum L(+)-LA	782:810	predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80	782:981	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	0	12	theme	Acid	90:93	arg1	Production					95:104	L(+)-Lactic Acid Production	78:104	L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1	78:165	Utilizing Gelatinized Starchy Waste from Rice Noodle Factory as Substrate for L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1.
32382944	1	13	theme	starchy	180:186	arg1	waste					188:192	starchy waste	180:192	starchy waste	180:192	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	7	14	theme	feasible	1413:1420	arg1	process					1436:1442	the feasible bioconversion process	1409:1442	the feasible bioconversion process for GSW utilizing as a substrate for L(+)-LA production	1409:1498	Not only showing the feasible bioconversion process for GSW utilizing as a substrate for L(+)-LA production, this research also demonstrated the efficient model for industrial starchy waste valorization.
32382944	2	15	theme	organic	498:504	arg1	sources					515:521	expensive organic nitrogen sources	488:521	expensive organic nitrogen sources	488:521	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	1	16	theme	polylactate	329:339	arg1	synthesis					341:349	polylactate synthesis	329:349	polylactate synthesis	329:349	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	6	17	theme	fermentation	1378:1389	arg1	stage					1364:1368	the early stage	1354:1368	the early stage of 24-h fermentation	1354:1389	Thinning GSW with α-amylase from Lactobacillus plantarum S21 increased L(+)-LA productivity in the early stage of 24-h fermentation.
32382944	2	18	theme	steep	542:546	arg1	CSL					556:558	CSL	556:558	CSL	556:558	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	2	18	theme	steep	542:546	arg1	liquor					548:553	corn steep liquor	537:553	corn steep liquor (CSL)	537:559	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	2	18	theme	steep	542:546	arg1	property					644:651	the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property	565:651	the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property	565:651	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	4	19	theme	salts	1039:1043	arg1	removal					1014:1020	removal	1014:1020	removal of all inorganic salts	1014:1043	Minimizing the medium cost by removal of all inorganic salts and Tween80 from OM was not an effect on L(+)-LA yield.
32382944	0	20	theme	Lactic	120:125	arg1	K-1					163:165	Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1	109:165	Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1	109:165	Utilizing Gelatinized Starchy Waste from Rice Noodle Factory as Substrate for L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1.
32382944	3	21	theme	maximum	796:802	arg1	L					804:804	the maximum L	792:804	the maximum L	792:804	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	2	22	theme	-LA	615:617	arg1	achievement					619:629	L(+)-LA achievement	611:629	L(+)-LA achievement	611:629	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	3	23	theme	composite	758:766	arg1	CCD					776:778	CCD	776:778	CCD	776:778	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	23	theme	composite	758:766	arg1	design					768:773	central composite design	750:773	central composite design (CCD)	750:779	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	0	24	theme	Bacterium	132:140	arg1	K-1					163:165	Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1	109:165	Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1	109:165	Utilizing Gelatinized Starchy Waste from Rice Noodle Factory as Substrate for L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1.
32382944	6	25	theme	early	1358:1362	arg1	stage					1364:1368	the early stage	1354:1368	the early stage of 24-h fermentation	1354:1389	Thinning GSW with α-amylase from Lactobacillus plantarum S21 increased L(+)-LA productivity in the early stage of 24-h fermentation.
32382944	3	26	theme	predicted	782:790	arg1	design					701:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	26	theme	predicted	782:790	arg1	-LA					808:810	predicted the maximum L(+)-LA	782:810	predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80	782:981	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	2	27	theme	appropriate	449:459	arg1	source					470:475	appropriate nitrogen source	449:475	appropriate nitrogen source	449:475	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	3	28	contain	containing	856:865	arg1	medium					844:849	the optimized medium	830:849	the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80	830:981	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	28	contain	containing	856:865	arg2	CSL					895:897	207.3 g/L CSL	885:897	207.3 g/L CSL	885:897	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	28	contain	containing	856:865	arg2	GSW					877:879	125.7 g/L GSW	867:879	125.7 g/L GSW	867:879	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	28	contain	containing	856:865	arg1	OM					852:853	OM	852:853	OM	852:853	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	1	29	theme	-lactic	299:305	arg1	acid					307:310	L(+)-lactic acid	295:310	acid	307:310	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	4	30	theme	L	1086:1086	arg1	yield					1094:1098	L(+)-LA yield	1086:1098	L(+)-LA yield	1086:1098	Minimizing the medium cost by removal of all inorganic salts and Tween80 from OM was not an effect on L(+)-LA yield.
32382944	4	31	from	effect	1076:1081	arg1	yield					1094:1098	L(+)-LA yield	1086:1098	L(+)-LA yield	1086:1098	Minimizing the medium cost by removal of all inorganic salts and Tween80 from OM was not an effect on L(+)-LA yield.
32382944	1	32	theme	waste	257:261	arg1	bioconversion					220:232	bioconversion	220:232	bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis,	220:350	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	2	33	theme	L	611:611	arg1	achievement					619:629	L(+)-LA achievement	611:629	L(+)-LA achievement	611:629	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	0	34	theme	Starchy	22:28	arg1	Waste					30:34	Gelatinized Starchy Waste	10:34	Gelatinized Starchy Waste from Rice Noodle Factory	10:59	Utilizing Gelatinized Starchy Waste from Rice Noodle Factory as Substrate for L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1.
32382944	4	35	from	OM	1062:1063	arg1	Tween80					1049:1055	Tween80	1049:1055	Tween80 from OM	1049:1063	Minimizing the medium cost by removal of all inorganic salts and Tween80 from OM was not an effect on L(+)-LA yield.
32382944	4	35	from	OM	1062:1063	arg1	effect					1076:1081	an effect	1073:1081	an effect on L(+)-LA yield	1073:1098	Minimizing the medium cost by removal of all inorganic salts and Tween80 from OM was not an effect on L(+)-LA yield.
32382944	3	36	theme	optimized	834:842	arg1	medium					844:849	the optimized medium	830:849	the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80	830:981	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	36	theme	optimized	834:842	arg1	OM					852:853	OM	852:853	OM	852:853	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	37	theme	125.7 g/L	867:875	arg1	GSW					877:879	125.7 g/L GSW	867:879	125.7 g/L GSW	867:879	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	0	38	theme	Noodle	46:51	arg1	Factory					53:59	Rice Noodle Factory	41:59	Rice Noodle Factory	41:59	Utilizing Gelatinized Starchy Waste from Rice Noodle Factory as Substrate for L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1.
32382944	1	39	theme	rice	199:202	arg1	factory					211:217	rice noodle factory	199:217	rice noodle factory	199:217	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	4	40	theme	-LA	1090:1092	arg1	yield					1094:1098	L(+)-LA yield	1086:1098	L(+)-LA yield	1086:1098	Minimizing the medium cost by removal of all inorganic salts and Tween80 from OM was not an effect on L(+)-LA yield.
32382944	7	41	theme	waste	1576:1580	arg1	valorization					1582:1593	industrial starchy waste valorization	1557:1593	industrial starchy waste valorization	1557:1593	Not only showing the feasible bioconversion process for GSW utilizing as a substrate for L(+)-LA production, this research also demonstrated the efficient model for industrial starchy waste valorization.
32382944	6	42	theme	Thinning	1259:1266	arg1	GSW					1268:1270	Thinning GSW	1259:1270	Thinning GSW with α-amylase from Lactobacillus plantarum S21	1259:1318	Thinning GSW with α-amylase from Lactobacillus plantarum S21 increased L(+)-LA productivity in the early stage of 24-h fermentation.
32382944	7	43	theme	industrial	1557:1566	arg1	valorization					1582:1593	industrial starchy waste valorization	1557:1593	industrial starchy waste valorization	1557:1593	Not only showing the feasible bioconversion process for GSW utilizing as a substrate for L(+)-LA production, this research also demonstrated the efficient model for industrial starchy waste valorization.
32382944	1	44	theme	lactic	386:391	arg1	acid					393:396	amylolytic lactic acid	375:396	amylolytic lactic acid bacterium	375:406	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	5	45	contain	containing	1166:1175	arg1	OM-Mi					1159:1163	OM-Mi	1159:1163	OM-Mi	1159:1163	Fermentation using the optimized medium without minerals (OM-Mi) containing only GSW (125.7 g/L) and CSL (207.3 g/L) in a 10-L fermenter was also successful.
32382944	5	45	contain	containing	1166:1175	arg2	GSW					1182:1184	only GSW	1177:1184	only GSW (125.7 g/L)	1177:1196	Fermentation using the optimized medium without minerals (OM-Mi) containing only GSW (125.7 g/L) and CSL (207.3 g/L) in a 10-L fermenter was also successful.
32382944	5	45	contain	containing	1166:1175	arg2	125.7 g/L					1187:1195	125.7 g/L	1187:1195	125.7 g/L	1187:1195	Fermentation using the optimized medium without minerals (OM-Mi) containing only GSW (125.7 g/L) and CSL (207.3 g/L) in a 10-L fermenter was also successful.
32382944	5	45	contain	containing	1166:1175	arg2	207.3 g/L					1207:1215	207.3 g/L	1207:1215	207.3 g/L	1207:1215	Fermentation using the optimized medium without minerals (OM-Mi) containing only GSW (125.7 g/L) and CSL (207.3 g/L) in a 10-L fermenter was also successful.
32382944	5	45	contain	containing	1166:1175	arg1	minerals					1149:1156	minerals	1149:1156	minerals (OM-Mi) containing only GSW (125.7 g/L) and CSL (207.3 g/L) in a 10-L fermenter	1149:1236	Fermentation using the optimized medium without minerals (OM-Mi) containing only GSW (125.7 g/L) and CSL (207.3 g/L) in a 10-L fermenter was also successful.
32382944	5	45	contain	containing	1166:1175	arg2	CSL					1202:1204	CSL	1202:1204	CSL (207.3 g/L)	1202:1216	Fermentation using the optimized medium without minerals (OM-Mi) containing only GSW (125.7 g/L) and CSL (207.3 g/L) in a 10-L fermenter was also successful.
32382944	1	46	theme	gelatinized	237:247	arg1	GSW					264:266	GSW	264:266	GSW	264:266	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	1	46	theme	gelatinized	237:247	arg1	waste					257:261	gelatinized starchy waste	237:261	gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis,	237:350	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	4	47	theme	medium	999:1004	arg1	cost					1006:1009	the medium cost	995:1009	the medium cost	995:1009	Minimizing the medium cost by removal of all inorganic salts and Tween80 from OM was not an effect on L(+)-LA yield.
32382944	3	48	theme	successful	658:667	arg1	design					701:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	48	theme	successful	658:667	arg1	design					725:730	Plackett-Burman design	709:730	Plackett-Burman design incorporated with central composite design (CCD)	709:779	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	48	theme	successful	658:667	arg1	-LA					808:810	predicted the maximum L(+)-LA	782:810	predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80	782:981	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	49	from	-LA	808:810	arg1	medium					844:849	the optimized medium	830:849	the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80	830:981	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	49	from	-LA	808:810	arg1	OM					852:853	OM	852:853	OM	852:853	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	6	50	with	GSW	1268:1270	arg1	α-amylase					1277:1285	α-amylase	1277:1285	α-amylase	1277:1285	Thinning GSW with α-amylase from Lactobacillus plantarum S21 increased L(+)-LA productivity in the early stage of 24-h fermentation.
32382944	1	51	theme	Enterococcus	409:420	arg1	bacterium					398:406	amylolytic lactic acid bacterium	375:406	amylolytic lactic acid bacterium	375:406	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	1	51	theme	Enterococcus	409:420	arg1	K-1					430:432	Enterococcus faecium K-1	409:432	Enterococcus faecium K-1	409:432	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	7	52	theme	bioconversion	1422:1434	arg1	process					1436:1442	the feasible bioconversion process	1409:1442	the feasible bioconversion process for GSW utilizing as a substrate for L(+)-LA production	1409:1498	Not only showing the feasible bioconversion process for GSW utilizing as a substrate for L(+)-LA production, this research also demonstrated the efficient model for industrial starchy waste valorization.
32382944	2	53	theme	nitrogen	506:513	arg1	sources					515:521	expensive organic nitrogen sources	488:521	expensive organic nitrogen sources	488:521	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	3	54	theme	statistic	678:686	arg1	design					701:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	54	theme	statistic	678:686	arg1	design					725:730	Plackett-Burman design	709:730	Plackett-Burman design incorporated with central composite design (CCD)	709:779	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	54	theme	statistic	678:686	arg1	-LA					808:810	predicted the maximum L(+)-LA	782:810	predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80	782:981	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	0	55	theme	Amylolytic	109:118	arg1	K-1					163:165	Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1	109:165	Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1	109:165	Utilizing Gelatinized Starchy Waste from Rice Noodle Factory as Substrate for L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1.
32382944	6	56	theme	plantarum	1306:1314	arg1	S21					1316:1318	Lactobacillus plantarum S21	1292:1318	Lactobacillus plantarum S21	1292:1318	Thinning GSW with α-amylase from Lactobacillus plantarum S21 increased L(+)-LA productivity in the early stage of 24-h fermentation.
32382944	2	57	theme	expensive	488:496	arg1	sources					515:521	expensive organic nitrogen sources	488:521	expensive organic nitrogen sources	488:521	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	3	58	from	medium	844:849	arg1	design					701:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	58	from	medium	844:849	arg1	93.07 g/L					815:823	93.07 g/L	815:823	93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80	815:981	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	58	from	medium	844:849	arg1	-LA					808:810	predicted the maximum L(+)-LA	782:810	predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80	782:981	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	2	59	theme	low-cost	635:642	arg1	liquor					548:553	corn steep liquor	537:553	corn steep liquor (CSL)	537:559	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	2	59	theme	low-cost	635:642	arg1	property					644:651	the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property	565:651	the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property	565:651	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	0	60	theme	Acid	127:130	arg1	K-1					163:165	Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1	109:165	Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1	109:165	Utilizing Gelatinized Starchy Waste from Rice Noodle Factory as Substrate for L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1.
32382944	6	61	theme	24-h	1373:1376	arg1	fermentation					1378:1389	24-h fermentation	1373:1389	24-h fermentation	1373:1389	Thinning GSW with α-amylase from Lactobacillus plantarum S21 increased L(+)-LA productivity in the early stage of 24-h fermentation.
32382944	0	62	dep	Enterococcus	142:153	arg1	faecium					155:161	faecium	155:161	faecium	155:161	Utilizing Gelatinized Starchy Waste from Rice Noodle Factory as Substrate for L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1.
32382944	2	63	theme	corn	537:540	arg1	CSL					556:558	CSL	556:558	CSL	556:558	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	2	63	theme	corn	537:540	arg1	liquor					548:553	corn steep liquor	537:553	corn steep liquor (CSL)	537:559	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	2	63	theme	corn	537:540	arg1	property					644:651	the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property	565:651	the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property	565:651	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	3	64	theme	Plackett-Burman	709:723	arg1	design					701:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	64	theme	Plackett-Burman	709:723	arg1	design					725:730	Plackett-Burman design	709:730	Plackett-Burman design incorporated with central composite design (CCD)	709:779	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	0	65	theme	Enterococcus	142:153	arg1	K-1					163:165	Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1	109:165	Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1	109:165	Utilizing Gelatinized Starchy Waste from Rice Noodle Factory as Substrate for L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1.
32382944	3	66	theme	L	804:804	arg1	design					701:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	66	theme	L	804:804	arg1	-LA					808:810	predicted the maximum L(+)-LA	782:810	predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80	782:981	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	4	67	theme	inorganic	1029:1037	arg1	salts					1039:1043	all inorganic salts	1025:1043	all inorganic salts	1025:1043	Minimizing the medium cost by removal of all inorganic salts and Tween80 from OM was not an effect on L(+)-LA yield.
32382944	3	68	theme	central	750:756	arg1	CCD					776:778	CCD	776:778	CCD	776:778	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	68	theme	central	750:756	arg1	design					768:773	central composite design	750:773	central composite design (CCD)	750:779	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	7	69	theme	-LA	1485:1487	arg1	production					1489:1498	L(+)-LA production	1481:1498	L(+)-LA production	1481:1498	Not only showing the feasible bioconversion process for GSW utilizing as a substrate for L(+)-LA production, this research also demonstrated the efficient model for industrial starchy waste valorization.
32382944	1	70	dep	Enterococcus	409:420	arg1	faecium					422:428	faecium	422:428	faecium	422:428	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	0	71	from	Factory	53:59	arg1	Waste					30:34	Gelatinized Starchy Waste	10:34	Gelatinized Starchy Waste from Rice Noodle Factory	10:59	Utilizing Gelatinized Starchy Waste from Rice Noodle Factory as Substrate for L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1.
32382944	2	72	theme	high	593:596	arg1	efficacy					598:605	high efficacy	593:605	high efficacy for L(+)-LA achievement	593:629	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	0	73	theme	-Lactic	82:88	arg1	Production					95:104	L(+)-Lactic Acid Production	78:104	L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1	78:165	Utilizing Gelatinized Starchy Waste from Rice Noodle Factory as Substrate for L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1.
32382944	7	74	theme	L	1481:1481	arg1	production					1489:1498	L(+)-LA production	1481:1498	L(+)-LA production	1481:1498	Not only showing the feasible bioconversion process for GSW utilizing as a substrate for L(+)-LA production, this research also demonstrated the efficient model for industrial starchy waste valorization.
32382944	2	75	theme	nitrogen	461:468	arg1	source					470:475	appropriate nitrogen source	449:475	appropriate nitrogen source	449:475	Screening for appropriate nitrogen source to replace expensive organic nitrogen sources revealed that corn steep liquor (CSL) was the most suitable regarding high efficacy for L(+)-LA achievement and low-cost property.
32382944	0	76	theme	Gelatinized	10:20	arg1	Waste					30:34	Gelatinized Starchy Waste	10:34	Gelatinized Starchy Waste from Rice Noodle Factory	10:59	Utilizing Gelatinized Starchy Waste from Rice Noodle Factory as Substrate for L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1.
32382944	3	77	theme	NH4	957:959	arg1	2HC6H5O7					961:968	(NH4)2HC6H5O7	956:968	(NH4)2HC6H5O7	956:968	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	6	78	from	S21	1316:1318	arg1	GSW					1268:1270	Thinning GSW	1259:1270	Thinning GSW with α-amylase from Lactobacillus plantarum S21	1259:1318	Thinning GSW with α-amylase from Lactobacillus plantarum S21 increased L(+)-LA productivity in the early stage of 24-h fermentation.
32382944	3	79	theme	93.07 g/L	815:823	arg1	design					701:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design	654:706	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	3	79	theme	93.07 g/L	815:823	arg1	-LA					808:810	predicted the maximum L(+)-LA	782:810	predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80	782:981	The successful applying statistic experimental design, Plackett-Burman design incorporated with central composite design (CCD), predicted the maximum L(+)-LA of 93.07 g/L from the optimized medium (OM) containing 125.7 g/L GSW and 207.3 g/L CSL supplemented with CH3COONa, MgSO4, MnSO4, K2HPO4, CaCl2, (NH4)2HC6H5O7, and Tween80.
32382944	5	80	theme	optimized	1124:1132	arg1	medium					1134:1139	the optimized medium	1120:1139	the optimized medium without minerals (OM-Mi) containing only GSW (125.7 g/L) and CSL (207.3 g/L) in a 10-L fermenter	1120:1236	Fermentation using the optimized medium without minerals (OM-Mi) containing only GSW (125.7 g/L) and CSL (207.3 g/L) in a 10-L fermenter was also successful.
32382944	0	81	theme	Rice	41:44	arg1	Factory					53:59	Rice Noodle Factory	41:59	Rice Noodle Factory	41:59	Utilizing Gelatinized Starchy Waste from Rice Noodle Factory as Substrate for L(+)-Lactic Acid Production by Amylolytic Lactic Acid Bacterium Enterococcus faecium K-1.
32382944	1	82	theme	value-added	272:282	arg1	product					284:290	value-added product	272:290	value-added product	272:290	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
32382944	6	83	theme	Lactobacillus	1292:1304	arg1	S21					1316:1318	Lactobacillus plantarum S21	1292:1318	Lactobacillus plantarum S21	1292:1318	Thinning GSW with α-amylase from Lactobacillus plantarum S21 increased L(+)-LA productivity in the early stage of 24-h fermentation.
32382944	5	84	theme	only	1177:1180	arg1	125.7 g/L					1187:1195	125.7 g/L	1187:1195	125.7 g/L	1187:1195	Fermentation using the optimized medium without minerals (OM-Mi) containing only GSW (125.7 g/L) and CSL (207.3 g/L) in a 10-L fermenter was also successful.
32382944	5	84	theme	only	1177:1180	arg1	GSW					1182:1184	only GSW	1177:1184	only GSW (125.7 g/L)	1177:1196	Fermentation using the optimized medium without minerals (OM-Mi) containing only GSW (125.7 g/L) and CSL (207.3 g/L) in a 10-L fermenter was also successful.
32382944	1	85	theme	noodle	204:209	arg1	factory					211:217	rice noodle factory	199:217	rice noodle factory	199:217	To valorize starchy waste from rice noodle factory, bioconversion of gelatinized starchy waste (GSW) to value-added product as L(+)-lactic acid, the monomer for polylactate synthesis, was investigated using amylolytic lactic acid bacterium, Enterococcus faecium K-1.
34520853	2	0	contain	containing	374:383	arg2	protein					402:408	high egg or whey protein	385:408	protein	402:408	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	2	0	contain	containing	374:383	arg2	egg					390:392	high egg or whey protein	385:408	egg	390:392	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	2	0	contain	containing	374:383	arg1	diets					368:372	diets	368:372	diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber	368:451	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	12	1	contain	containing	1717:1726	arg2	egg					1728:1730	egg	1728:1730	egg	1728:1730	Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
34520853	12	1	contain	containing	1717:1726	arg2	protein					1740:1746	whey protein	1735:1746	whey protein	1735:1746	Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
34520853	12	1	contain	containing	1717:1726	arg1	diets					1711:1715	inulin enriched diets	1695:1715	inulin enriched diets containing egg or whey protein	1695:1746	Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
34520853	12	2	theme	CCK	1845:1847	arg1	signaling					1849:1857	CCK signaling	1845:1857	CCK signaling partly mediating the satiety effects of diets	1845:1903	Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
34520853	1	3	from	effects	256:262	arg1	balance					305:311	energy balance	298:311	energy balance	298:311	Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition.
34520853	1	3	from	effects	256:262	arg1	composition					332:342	gut microbiota composition	317:342	gut microbiota composition	317:342	Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition.
34520853	3	4	theme	Egg	601:603	arg1	albumen+Inulin					605:618	Egg albumen+Inulin	601:618	Egg albumen+Inulin (EI)	601:623	Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI).
34520853	3	4	theme	Egg	601:603	arg1	EI					621:622	EI	621:622	EI	621:622	Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI).
34520853	8	5	from	hormones	1214:1221	arg1	tissue					1199:1204	brown adipose tissue	1185:1204	brown adipose tissue	1185:1204	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	9	6	from	%	1348:1348	arg1	microbiomes					1388:1398	cecal microbiomes	1382:1398	cecal microbiomes	1382:1398	Diet explained 25% of compositional differences in cecal microbiomes, but diets with same fiber type did not differ.
34520853	3	7	theme	Whey	626:629	arg1	WC					650:651	WC	650:651	WC	650:651	Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI).
34520853	3	7	theme	Whey	626:629	arg1	protein+Cellulose					631:647	Whey protein+Cellulose	626:647	Whey protein+Cellulose (WC)	626:652	Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI).
34520853	6	8	dep	weight	979:984	arg1	gains					1000:1004	gains	1000:1004	gains	1000:1004	Further, EC, EI and WI decreased respiratory quotient, energy expenditure, weight and adiposity gains, and improved glycemia, relative to WC.
34520853	1	9	theme	microbiota	321:330	arg1	composition					332:342	gut microbiota composition	317:342	gut microbiota composition	317:342	Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition.
34520853	8	10	dep	markers	1174:1180	arg1	glycerophospholipids					1271:1290	glycerophospholipids	1271:1290	glycerophospholipids	1271:1290	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	8	10	dep	markers	1174:1180	arg1	acyl-carnitines					1251:1265	acyl-carnitines	1251:1265	acyl-carnitines	1251:1265	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	3	11	theme	obese	520:524	arg1	n=8/group					532:540	n=8/group	532:540	n=8/group	532:540	Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI).
34520853	3	11	theme	obese	520:524	arg1	rats					526:529	Male obese rats	515:529	Male obese rats (n=8/group)	515:541	Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI).
34520853	1	12	theme	food	185:188	arg1	intake					190:195	food intake	185:195	food intake	185:195	Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition.
34520853	12	13	theme	gut	1808:1810	arg1	microbiota					1812:1821	gut microbiota	1808:1821	gut microbiota	1808:1821	Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
34520853	5	14	theme	EC	888:889	arg1	effects					877:883	the hypophagic effects	862:883	the hypophagic effects of EC, EI, and WI	862:901	Importantly, CCK-1 receptor antagonist (Devazepide) attenuated the hypophagic effects of EC, EI, and WI.
34520853	6	15	theme	improved	1011:1018	arg1	glycemia					1020:1027	improved glycemia	1011:1027	improved glycemia	1011:1027	Further, EC, EI and WI decreased respiratory quotient, energy expenditure, weight and adiposity gains, and improved glycemia, relative to WC.
34520853	11	16	theme	butyrate	1593:1600	arg1	production					1602:1611	butyrate production	1593:1611	butyrate production	1593:1611	Species most strongly correlated to a marker for butyrate production were in highest abundance in inulin diets.
34520853	5	17	theme	EI	892:893	arg1	effects					877:883	the hypophagic effects	862:883	the hypophagic effects of EC, EI, and WI	862:901	Importantly, CCK-1 receptor antagonist (Devazepide) attenuated the hypophagic effects of EC, EI, and WI.
34520853	4	18	with	transient	735:743	arg1	EC					750:751	EC	750:751	EC	750:751	Results revealed that diet-induced hypophagia was transient with EC and prolonged with EI and WI, compared to WC.
34520853	2	19	theme	inulin	439:444	arg1	fiber					447:451	prebiotic (inulin) fiber	428:451	prebiotic (inulin) fiber	428:451	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	12	20	theme	diets	1899:1903	arg1	effects					1888:1894	the satiety effects	1876:1894	the satiety effects of diets	1876:1903	Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
34520853	9	21	theme	compositional	1353:1365	arg1	differences					1367:1377	compositional differences	1353:1377	compositional differences in cecal microbiomes	1353:1398	Diet explained 25% of compositional differences in cecal microbiomes, but diets with same fiber type did not differ.
34520853	2	22	theme	prebiotic	428:436	arg1	fiber					447:451	prebiotic (inulin) fiber	428:451	prebiotic (inulin) fiber	428:451	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	11	23	theme	highest	1621:1627	arg1	abundance					1629:1637	highest abundance	1621:1637	highest abundance in inulin diets	1621:1653	Species most strongly correlated to a marker for butyrate production were in highest abundance in inulin diets.
34520853	1	24	theme	fiber	289:293	arg1	effects					256:262	the combined effects	243:262	the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition	243:342	Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition.
34520853	2	25	theme	energy	456:461	arg1	balance					463:469	energy balance	456:469	energy balance	456:469	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	8	26	theme	thermogenic	1162:1172	arg1	markers					1174:1180	thermogenic markers	1162:1180	thermogenic markers in brown adipose tissue	1162:1204	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	1	27	theme	energy	298:303	arg1	balance					305:311	energy balance	298:311	energy balance	298:311	Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition.
34520853	5	28	theme	CCK-1	812:816	arg1	Devazepide					839:848	Devazepide	839:848	Devazepide	839:848	Importantly, CCK-1 receptor antagonist (Devazepide) attenuated the hypophagic effects of EC, EI, and WI.
34520853	5	28	theme	CCK-1	812:816	arg1	antagonist					827:836	CCK-1 receptor antagonist	812:836	CCK-1 receptor antagonist (Devazepide)	812:849	Importantly, CCK-1 receptor antagonist (Devazepide) attenuated the hypophagic effects of EC, EI, and WI.
34520853	0	29	theme	gut	88:90	arg1	microbiota					92:101	gut microbiota	88:101	gut microbiota	88:101	Dietary whey and egg proteins interact with inulin fiber to modulate energy balance and gut microbiota in obese rats.
34520853	12	30	theme	whey	1735:1738	arg1	protein					1740:1746	whey protein	1735:1746	whey protein	1735:1746	Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
34520853	8	31	from	abundance	1149:1157	arg1	tissue					1199:1204	brown adipose tissue	1185:1204	brown adipose tissue	1185:1204	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	8	32	theme	adipose	1191:1197	arg1	tissue					1199:1204	brown adipose tissue	1185:1204	brown adipose tissue	1185:1204	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	0	33	theme	Dietary	0:6	arg1	whey					8:11	Dietary whey and egg proteins	0:28	whey	8:11	Dietary whey and egg proteins interact with inulin fiber to modulate energy balance and gut microbiota in obese rats.
34520853	2	34	theme	high	385:388	arg1	egg					390:392	high egg or whey protein	385:408	egg	390:392	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	2	35	theme	diets	368:372	arg1	effects					357:363	effects	357:363	effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites	357:512	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	9	36	theme	fiber	1421:1425	arg1	type					1427:1430	same fiber type	1416:1430	same fiber type	1416:1430	Diet explained 25% of compositional differences in cecal microbiomes, but diets with same fiber type did not differ.
34520853	7	37	theme	energy	1118:1123	arg1	expenditure					1125:1135	energy expenditure	1118:1135	energy expenditure	1118:1135	Propranolol (β1-β2-receptor blocker) attenuated diet-induced changes in energy expenditure.
34520853	8	38	theme	hormones	1214:1221	arg1	abundance					1149:1157	Transcript abundance	1138:1157	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids,	1138:1291	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	10	39	theme	gut	1514:1516	arg1	hormones					1518:1525	gut hormones	1514:1525	gut hormones	1514:1525	Microbiota differing between groups also strongly correlated with gut hormones and metabolites.
34520853	1	40	theme	combined	247:254	arg1	effects					256:262	the combined effects	243:262	the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition	243:342	Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition.
34520853	5	41	theme	hypophagic	866:875	arg1	effects					877:883	the hypophagic effects	862:883	the hypophagic effects of EC, EI, and WI	862:901	Importantly, CCK-1 receptor antagonist (Devazepide) attenuated the hypophagic effects of EC, EI, and WI.
34520853	8	42	from	markers	1174:1180	arg1	tissue					1199:1204	brown adipose tissue	1185:1204	brown adipose tissue	1185:1204	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	12	43	theme	inulin	1695:1700	arg1	diets					1711:1715	inulin enriched diets	1695:1715	inulin enriched diets containing egg or whey protein	1695:1746	Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
34520853	2	44	from	effects	357:363	arg1	hormones					488:495	hormones	488:495	hormones	488:495	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	2	44	from	effects	357:363	arg1	balance					463:469	energy balance	456:469	energy balance	456:469	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	2	44	from	effects	357:363	arg1	microbiota					476:485	gut microbiota	472:485	gut microbiota	472:485	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	2	44	from	effects	357:363	arg1	metabolites					502:512	metabolites	502:512	metabolites	502:512	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	1	45	theme	weight	201:206	arg1	gain					208:211	weight gain	201:211	weight gain	201:211	Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition.
34520853	8	46	from	tissue	1199:1204	arg1	abundance					1149:1157	Transcript abundance	1138:1157	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids,	1138:1291	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	12	47	theme	satiety	1880:1886	arg1	effects					1888:1894	the satiety effects	1876:1894	the satiety effects of diets	1876:1903	Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
34520853	9	48	from	differences	1367:1377	arg1	microbiomes					1388:1398	cecal microbiomes	1382:1398	cecal microbiomes	1382:1398	Diet explained 25% of compositional differences in cecal microbiomes, but diets with same fiber type did not differ.
34520853	4	49	theme	diet-induced	707:718	arg1	hypophagia					720:729	diet-induced hypophagia	707:729	diet-induced hypophagia	707:729	Results revealed that diet-induced hypophagia was transient with EC and prolonged with EI and WI, compared to WC.
34520853	6	50	theme	energy	959:964	arg1	expenditure					966:976	energy expenditure	959:976	energy expenditure	959:976	Further, EC, EI and WI decreased respiratory quotient, energy expenditure, weight and adiposity gains, and improved glycemia, relative to WC.
34520853	9	51	with	diets	1405:1409	arg1	type					1427:1430	same fiber type	1416:1430	same fiber type	1416:1430	Diet explained 25% of compositional differences in cecal microbiomes, but diets with same fiber type did not differ.
34520853	0	52	theme	obese	106:110	arg1	rats					112:115	obese rats	106:115	obese rats	106:115	Dietary whey and egg proteins interact with inulin fiber to modulate energy balance and gut microbiota in obese rats.
34520853	2	53	theme	gut	472:474	arg1	microbiota					476:485	gut microbiota	472:485	gut microbiota	472:485	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	11	54	theme	inulin	1642:1647	arg1	diets					1649:1653	inulin diets	1642:1653	inulin diets	1642:1653	Species most strongly correlated to a marker for butyrate production were in highest abundance in inulin diets.
34520853	5	55	theme	WI	900:901	arg1	effects					877:883	the hypophagic effects	862:883	the hypophagic effects of EC, EI, and WI	862:901	Importantly, CCK-1 receptor antagonist (Devazepide) attenuated the hypophagic effects of EC, EI, and WI.
34520853	3	56	theme	Male	515:518	arg1	n=8/group					532:540	n=8/group	532:540	n=8/group	532:540	Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI).
34520853	3	56	theme	Male	515:518	arg1	rats					526:529	Male obese rats	515:529	Male obese rats (n=8/group)	515:541	Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI).
34520853	8	57	from	metabolites	1228:1238	arg1	tissue					1199:1204	brown adipose tissue	1185:1204	brown adipose tissue	1185:1204	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	11	58	from	abundance	1629:1637	arg1	diets					1649:1653	inulin diets	1642:1653	inulin diets	1642:1653	Species most strongly correlated to a marker for butyrate production were in highest abundance in inulin diets.
34520853	3	59	theme	Whey	659:662	arg1	protein+Inulin					664:677	Whey protein+Inulin	659:677	Whey protein+Inulin (WI)	659:682	Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI).
34520853	3	59	theme	Whey	659:662	arg1	WI					680:681	WI	680:681	WI	680:681	Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI).
34520853	0	60	theme	energy	69:74	arg1	balance					76:82	energy balance	69:82	energy balance	69:82	Dietary whey and egg proteins interact with inulin fiber to modulate energy balance and gut microbiota in obese rats.
34520853	1	61	theme	prebiotic	279:287	arg1	fiber					289:293	prebiotic fiber	279:293	prebiotic fiber	279:293	Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition.
34520853	9	62	theme	differences	1367:1377	arg1	%					1348:1348	25%	1346:1348	25% of compositional differences in cecal microbiomes	1346:1398	Diet explained 25% of compositional differences in cecal microbiomes, but diets with same fiber type did not differ.
34520853	9	62	theme	differences	1367:1377	arg1	differences					1367:1377	compositional differences	1353:1377	compositional differences in cecal microbiomes	1353:1398	Diet explained 25% of compositional differences in cecal microbiomes, but diets with same fiber type did not differ.
34520853	8	63	theme	Transcript	1138:1147	arg1	abundance					1149:1157	Transcript abundance	1138:1157	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids,	1138:1291	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	12	64	with	microbiota	1812:1821	arg1	signaling					1849:1857	CCK signaling	1845:1857	CCK signaling partly mediating the satiety effects of diets	1845:1903	Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
34520853	12	65	with	metabolites	1827:1837	arg1	signaling					1849:1857	CCK signaling	1845:1857	CCK signaling partly mediating the satiety effects of diets	1845:1903	Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
34520853	9	66	theme	cecal	1382:1386	arg1	microbiomes					1388:1398	cecal microbiomes	1382:1398	cecal microbiomes	1382:1398	Diet explained 25% of compositional differences in cecal microbiomes, but diets with same fiber type did not differ.
34520853	9	67	from	microbiomes	1388:1398	arg1	%					1348:1348	25%	1346:1348	25% of compositional differences in cecal microbiomes	1346:1398	Diet explained 25% of compositional differences in cecal microbiomes, but diets with same fiber type did not differ.
34520853	9	67	from	microbiomes	1388:1398	arg1	differences					1367:1377	compositional differences	1353:1377	compositional differences in cecal microbiomes	1353:1398	Diet explained 25% of compositional differences in cecal microbiomes, but diets with same fiber type did not differ.
34520853	5	68	theme	receptor	818:825	arg1	Devazepide					839:848	Devazepide	839:848	Devazepide	839:848	Importantly, CCK-1 receptor antagonist (Devazepide) attenuated the hypophagic effects of EC, EI, and WI.
34520853	5	68	theme	receptor	818:825	arg1	antagonist					827:836	CCK-1 receptor antagonist	812:836	CCK-1 receptor antagonist (Devazepide)	812:849	Importantly, CCK-1 receptor antagonist (Devazepide) attenuated the hypophagic effects of EC, EI, and WI.
34520853	8	69	theme	markers	1174:1180	arg1	abundance					1149:1157	Transcript abundance	1138:1157	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids,	1138:1291	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	1	70	theme	gut	317:319	arg1	composition					332:342	gut microbiota composition	317:342	gut microbiota composition	317:342	Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition.
34520853	12	71	theme	energy	1757:1762	arg1	balance					1764:1770	energy balance	1757:1770	energy balance	1757:1770	Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
34520853	8	72	theme	brown	1185:1189	arg1	tissue					1199:1204	brown adipose tissue	1185:1204	brown adipose tissue	1185:1204	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	0	73	theme	egg	17:19	arg1	proteins					21:28	Dietary whey and egg proteins	0:28	proteins	21:28	Dietary whey and egg proteins interact with inulin fiber to modulate energy balance and gut microbiota in obese rats.
34520853	9	74	theme	same	1416:1419	arg1	type					1427:1430	same fiber type	1416:1430	same fiber type	1416:1430	Diet explained 25% of compositional differences in cecal microbiomes, but diets with same fiber type did not differ.
34520853	7	75	theme	diet-induced	1094:1105	arg1	changes					1107:1113	diet-induced changes	1094:1113	diet-induced changes in energy expenditure	1094:1135	Propranolol (β1-β2-receptor blocker) attenuated diet-induced changes in energy expenditure.
34520853	8	76	theme	plasma	1207:1212	arg1	hormones					1214:1221	plasma hormones	1207:1221	plasma hormones	1207:1221	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
34520853	0	77	theme	inulin	44:49	arg1	fiber					51:55	inulin fiber	44:55	inulin fiber	44:55	Dietary whey and egg proteins interact with inulin fiber to modulate energy balance and gut microbiota in obese rats.
34520853	7	78	from	changes	1107:1113	arg1	expenditure					1125:1135	energy expenditure	1118:1135	energy expenditure	1118:1135	Propranolol (β1-β2-receptor blocker) attenuated diet-induced changes in energy expenditure.
34520853	6	79	theme	respiratory	937:947	arg1	quotient					949:956	respiratory quotient	937:956	respiratory quotient	937:956	Further, EC, EI and WI decreased respiratory quotient, energy expenditure, weight and adiposity gains, and improved glycemia, relative to WC.
34520853	2	80	theme	whey	397:400	arg1	protein					402:408	high egg or whey protein	385:408	protein	402:408	We compared effects of diets containing high egg or whey protein with cellulose or prebiotic (inulin) fiber on energy balance, gut microbiota, hormones, and metabolites.
34520853	3	81	theme	Egg	573:575	arg1	EC					596:597	EC	596:597	EC	596:597	Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI).
34520853	3	81	theme	Egg	573:575	arg1	albumen+Cellulose					577:593	Egg albumen+Cellulose	573:593	Egg albumen+Cellulose (EC)	573:598	Male obese rats (n=8/group) were allocated to four diets: Egg albumen+Cellulose (EC), Egg albumen+Inulin (EI), Whey protein+Cellulose (WC), and Whey protein+Inulin (WI).
34520853	1	82	theme	protein	267:273	arg1	effects					256:262	the combined effects	243:262	the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition	243:342	Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition.
34520853	12	83	theme	enriched	1702:1709	arg1	diets					1711:1715	inulin enriched diets	1695:1715	inulin enriched diets containing egg or whey protein	1695:1746	Together, these findings indicate that inulin enriched diets containing egg or whey protein improved energy balance, decreased adiposity, and modulated gut microbiota and metabolites, with CCK signaling partly mediating the satiety effects of diets.
34520853	7	84	theme	β1-β2-receptor	1059:1072	arg1	Propranolol					1046:1056	Propranolol	1046:1056	Propranolol (β1-β2-receptor blocker)	1046:1081	Propranolol (β1-β2-receptor blocker) attenuated diet-induced changes in energy expenditure.
34520853	7	84	theme	β1-β2-receptor	1059:1072	arg1	blocker					1074:1080	β1-β2-receptor blocker	1059:1080	β1-β2-receptor blocker	1059:1080	Propranolol (β1-β2-receptor blocker) attenuated diet-induced changes in energy expenditure.
34520853	8	85	theme	metabolites	1228:1238	arg1	abundance					1149:1157	Transcript abundance	1138:1157	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids,	1138:1291	Transcript abundance of thermogenic markers in brown adipose tissue, plasma hormones, and metabolites especially acyl-carnitines and glycerophospholipids, were differentially altered by diets.
32815998	0	0	theme	dilution	100:107	arg1	pressure					109:116	high dilution pressure	95:116	high dilution pressure	95:116	Structurally complex carbohydrates maintain diversity in gut-derived microbial consortia under high dilution pressure.
32815998	7	1	theme	metabolic	1607:1615	arg1	interactions					1617:1628	other metabolic interactions	1601:1628	other metabolic interactions	1601:1628	These data suggest that carbohydrate structural complexity affords independent niches that structure fermenting microbial consortia, whereas other metabolic interactions govern the composition of communities fermenting simpler carbohydrates.
32815998	3	2	theme	monosaccharide	871:884	arg1	carbohydrates					918:930	model carbohydrates	912:930	model carbohydrates	912:930	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	2	theme	monosaccharide	871:884	arg1	controls					886:893	their corresponding monosaccharide controls	851:893	their corresponding monosaccharide controls	851:893	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	2	theme	monosaccharide	871:884	arg1	inulin					805:810	inulin	805:810	inulin (a low-complexity oligosaccharide)	805:845	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	2	theme	monosaccharide	871:884	arg1	arabinoxylan					759:770	Sorghum arabinoxylan	751:770	Sorghum arabinoxylan (SAX, a complex polysaccharide)	751:802	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	1	3	theme	shaping	175:181	arg1	microbiota					187:196	and shaping gut microbiota	171:196	microbiota	187:196	Dietary fibers are major substrates for maintaining and shaping gut microbiota, but the structural specificity of these fibers for the diversity, structure and function of gut microbiota are poorly understood.
32815998	7	4	theme	microbial	1572:1580	arg1	consortia					1582:1590	structure fermenting microbial consortia	1551:1590	structure fermenting microbial consortia	1551:1590	These data suggest that carbohydrate structural complexity affords independent niches that structure fermenting microbial consortia, whereas other metabolic interactions govern the composition of communities fermenting simpler carbohydrates.
32815998	3	5	theme	low-complexity	815:828	arg1	inulin					805:810	inulin	805:810	inulin (a low-complexity oligosaccharide)	805:845	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	5	theme	low-complexity	815:828	arg1	oligosaccharide					830:844	a low-complexity oligosaccharide	813:844	a low-complexity oligosaccharide	813:844	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	0	6	theme	high	95:98	arg1	pressure					109:116	high dilution pressure	95:116	high dilution pressure	95:116	Structurally complex carbohydrates maintain diversity in gut-derived microbial consortia under high dilution pressure.
32815998	3	7	dep	arabinoxylan	759:770	arg1	polysaccharide					788:801	a complex polysaccharide	778:801	a complex polysaccharide	778:801	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	7	dep	arabinoxylan	759:770	arg1	SAX					773:775	SAX	773:775	SAX	773:775	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	2	8	theme	substrate	589:597	arg1	structuring					599:609	substrate structuring	589:609	substrate structuring	589:609	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	1	9	theme	gut	183:185	arg1	microbiota					187:196	and shaping gut microbiota	171:196	microbiota	187:196	Dietary fibers are major substrates for maintaining and shaping gut microbiota, but the structural specificity of these fibers for the diversity, structure and function of gut microbiota are poorly understood.
32815998	2	10	dep	exchange	668:675	arg1	e.g.					663:666	e.g.	663:666	e.g.	663:666	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	6	11	theme	experiments	1447:1457	arg1	outcomes					1406:1413	the outcomes	1402:1413	the outcomes of sequential batch cultivation experiments	1402:1457	Finally, very similar final consortia were enriched on SAX from the same individual's fecal microbiota one month later, suggesting that polysaccharide structure is more influential than stochastic alterations in microbiome composition in governing the outcomes of sequential batch cultivation experiments.
32815998	2	12	theme	acids	686:690	arg1	exchange					668:675	exchange	668:675	exchange of amino acids or vitamins	668:702	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	7	13	theme	carbohydrate	1484:1495	arg1	complexity					1508:1517	carbohydrate structural complexity	1484:1517	carbohydrate structural complexity	1484:1517	These data suggest that carbohydrate structural complexity affords independent niches that structure fermenting microbial consortia, whereas other metabolic interactions govern the composition of communities fermenting simpler carbohydrates.
32815998	7	14	theme	carbohydrates	1687:1699	arg1	composition					1641:1651	the composition	1637:1651	the composition of communities fermenting simpler carbohydrates	1637:1699	These data suggest that carbohydrate structural complexity affords independent niches that structure fermenting microbial consortia, whereas other metabolic interactions govern the composition of communities fermenting simpler carbohydrates.
32815998	4	15	theme	complex	962:968	arg1	carbohydrates					970:982	complex carbohydrates	962:982	complex carbohydrates	962:982	Our results demonstrate that complex carbohydrates stably sustain diverse microbial consortia.
32815998	7	16	theme	communities	1656:1666	arg1	carbohydrates					1687:1699	communities fermenting simpler carbohydrates	1656:1699	communities fermenting simpler carbohydrates	1656:1699	These data suggest that carbohydrate structural complexity affords independent niches that structure fermenting microbial consortia, whereas other metabolic interactions govern the composition of communities fermenting simpler carbohydrates.
32815998	2	17	dep	in	350:351	arg1	vitro					353:357	vitro	353:357	vitro	353:357	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	6	18	theme	batch	1429:1433	arg1	experiments					1447:1457	sequential batch cultivation experiments	1418:1457	sequential batch cultivation experiments	1418:1457	Finally, very similar final consortia were enriched on SAX from the same individual's fecal microbiota one month later, suggesting that polysaccharide structure is more influential than stochastic alterations in microbiome composition in governing the outcomes of sequential batch cultivation experiments.
32815998	2	19	theme	metabolic	639:647	arg1	interactions					649:660	obligate microbe-microbe metabolic interactions	614:660	obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins)	614:703	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	6	20	theme	sequential	1418:1427	arg1	experiments					1447:1457	sequential batch cultivation experiments	1418:1457	sequential batch cultivation experiments	1418:1457	Finally, very similar final consortia were enriched on SAX from the same individual's fecal microbiota one month later, suggesting that polysaccharide structure is more influential than stochastic alterations in microbiome composition in governing the outcomes of sequential batch cultivation experiments.
32815998	7	21	theme	structure	1551:1559	arg1	consortia					1582:1590	structure fermenting microbial consortia	1551:1590	structure fermenting microbial consortia	1551:1590	These data suggest that carbohydrate structural complexity affords independent niches that structure fermenting microbial consortia, whereas other metabolic interactions govern the composition of communities fermenting simpler carbohydrates.
32815998	2	22	theme	microbe-microbe	623:637	arg1	interactions					649:660	obligate microbe-microbe metabolic interactions	614:660	obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins)	614:703	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	7	23	theme	independent	1527:1537	arg1	niches					1539:1544	independent niches	1527:1544	independent niches that structure fermenting microbial consortia	1527:1590	These data suggest that carbohydrate structural complexity affords independent niches that structure fermenting microbial consortia, whereas other metabolic interactions govern the composition of communities fermenting simpler carbohydrates.
32815998	0	24	theme	complex	13:19	arg1	carbohydrates					21:33	Structurally complex carbohydrates	0:33	Structurally complex carbohydrates	0:33	Structurally complex carbohydrates maintain diversity in gut-derived microbial consortia under high dilution pressure.
32815998	7	25	theme	fermenting	1561:1570	arg1	consortia					1582:1590	structure fermenting microbial consortia	1551:1590	structure fermenting microbial consortia	1551:1590	These data suggest that carbohydrate structural complexity affords independent niches that structure fermenting microbial consortia, whereas other metabolic interactions govern the composition of communities fermenting simpler carbohydrates.
32815998	2	26	theme	obligate	614:621	arg1	interactions					649:660	obligate microbe-microbe metabolic interactions	614:660	obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins)	614:703	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	0	27	link	gut-derived	57:67	arg1	consortia					79:87	gut-derived microbial consortia	57:87	gut-derived microbial consortia	57:87	Structurally complex carbohydrates maintain diversity in gut-derived microbial consortia under high dilution pressure.
32815998	7	28	theme	structural	1497:1506	arg1	complexity					1508:1517	carbohydrate structural complexity	1484:1517	carbohydrate structural complexity	1484:1517	These data suggest that carbohydrate structural complexity affords independent niches that structure fermenting microbial consortia, whereas other metabolic interactions govern the composition of communities fermenting simpler carbohydrates.
32815998	3	29	theme	model	912:916	arg1	carbohydrates					918:930	model carbohydrates	912:930	model carbohydrates	912:930	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	29	theme	model	912:916	arg1	arabinoxylan					759:770	Sorghum arabinoxylan	751:770	Sorghum arabinoxylan (SAX, a complex polysaccharide)	751:802	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	29	theme	model	912:916	arg1	inulin					805:810	inulin	805:810	inulin (a low-complexity oligosaccharide)	805:845	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	29	theme	model	912:916	arg1	controls					886:893	their corresponding monosaccharide controls	851:893	their corresponding monosaccharide controls	851:893	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	2	30	theme	culture	382:388	arg1	approach					390:397	an in vitro sequential batch fecal culture approach	347:397	an in vitro sequential batch fecal culture approach to address two ecological questions	347:433	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	6	31	theme	polysaccharide	1290:1303	arg1	structure					1305:1313	polysaccharide structure	1290:1313	polysaccharide structure	1290:1313	Finally, very similar final consortia were enriched on SAX from the same individual's fecal microbiota one month later, suggesting that polysaccharide structure is more influential than stochastic alterations in microbiome composition in governing the outcomes of sequential batch cultivation experiments.
32815998	2	32	theme	amino	680:684	arg1	acids					686:690	amino acids	680:690	amino acids	680:690	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	2	33	theme	fecal	376:380	arg1	approach					390:397	an in vitro sequential batch fecal culture approach	347:397	an in vitro sequential batch fecal culture approach to address two ecological questions	347:433	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	1	34	theme	gut	291:293	arg1	microbiota					295:304	gut microbiota	291:304	gut microbiota	291:304	Dietary fibers are major substrates for maintaining and shaping gut microbiota, but the structural specificity of these fibers for the diversity, structure and function of gut microbiota are poorly understood.
32815998	2	35	theme	high	553:556	arg1	pressure					567:574	high dilution pressure	553:574	high dilution pressure (ii)	553:579	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	2	35	theme	high	553:556	arg1	ii					577:578	ii	577:578	ii	577:578	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	6	36	theme	stochastic	1340:1349	arg1	alterations					1351:1361	stochastic alterations	1340:1361	stochastic alterations in microbiome composition	1340:1387	Finally, very similar final consortia were enriched on SAX from the same individual's fecal microbiota one month later, suggesting that polysaccharide structure is more influential than stochastic alterations in microbiome composition in governing the outcomes of sequential batch cultivation experiments.
32815998	1	37	theme	Dietary	119:125	arg1	substrates					144:153	major substrates	138:153	major substrates for maintaining and shaping gut microbiota	138:196	Dietary fibers are major substrates for maintaining and shaping gut microbiota, but the structural specificity of these fibers for the diversity, structure and function of gut microbiota are poorly understood.
32815998	1	37	theme	Dietary	119:125	arg1	fibers					127:132	Dietary fibers	119:132	Dietary fibers	119:132	Dietary fibers are major substrates for maintaining and shaping gut microbiota, but the structural specificity of these fibers for the diversity, structure and function of gut microbiota are poorly understood.
32815998	1	38	theme	structural	207:216	arg1	specificity					218:228	the structural specificity	203:228	the structural specificity of these fibers for the diversity, structure and function of gut microbiota	203:304	Dietary fibers are major substrates for maintaining and shaping gut microbiota, but the structural specificity of these fibers for the diversity, structure and function of gut microbiota are poorly understood.
32815998	1	39	theme	microbiota	295:304	arg1	structure					265:273	structure	265:273	structure	265:273	Dietary fibers are major substrates for maintaining and shaping gut microbiota, but the structural specificity of these fibers for the diversity, structure and function of gut microbiota are poorly understood.
32815998	1	39	theme	microbiota	295:304	arg1	diversity					254:262	diversity	254:262	diversity	254:262	Dietary fibers are major substrates for maintaining and shaping gut microbiota, but the structural specificity of these fibers for the diversity, structure and function of gut microbiota are poorly understood.
32815998	1	39	theme	microbiota	295:304	arg1	function					279:286	function	279:286	function	279:286	Dietary fibers are major substrates for maintaining and shaping gut microbiota, but the structural specificity of these fibers for the diversity, structure and function of gut microbiota are poorly understood.
32815998	7	40	theme	fermenting	1668:1677	arg1	carbohydrates					1687:1699	communities fermenting simpler carbohydrates	1656:1699	communities fermenting simpler carbohydrates	1656:1699	These data suggest that carbohydrate structural complexity affords independent niches that structure fermenting microbial consortia, whereas other metabolic interactions govern the composition of communities fermenting simpler carbohydrates.
32815998	2	41	theme	in	350:351	arg1	approach					390:397	an in vitro sequential batch fecal culture approach	347:397	an in vitro sequential batch fecal culture approach to address two ecological questions	347:433	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	2	42	theme	ecological	414:423	arg1	questions					425:433	two ecological questions	410:433	two ecological questions	410:433	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	3	43	theme	Sorghum	751:757	arg1	arabinoxylan					759:770	Sorghum arabinoxylan	751:770	Sorghum arabinoxylan (SAX, a complex polysaccharide)	751:802	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	43	theme	Sorghum	751:757	arg1	carbohydrates					918:930	model carbohydrates	912:930	model carbohydrates	912:930	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	43	theme	Sorghum	751:757	arg1	inulin					805:810	inulin	805:810	inulin (a low-complexity oligosaccharide)	805:845	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	43	theme	Sorghum	751:757	arg1	controls					886:893	their corresponding monosaccharide controls	851:893	their corresponding monosaccharide controls	851:893	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	1	44	dep	diversity	254:262	arg1	the					250:252	the	250:252	the	250:252	Dietary fibers are major substrates for maintaining and shaping gut microbiota, but the structural specificity of these fibers for the diversity, structure and function of gut microbiota are poorly understood.
32815998	2	45	theme	chemical	452:459	arg1	complexity					461:470	the chemical complexity	448:470	the chemical complexity of a carbohydrate	448:488	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	2	46	theme	microbial	525:533	arg1	diversity					535:543	microbial diversity	525:543	microbial diversity against high dilution pressure (ii)	525:579	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	2	47	theme	more	711:714	arg1	influence					716:724	more influence	711:724	more influence	711:724	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	0	48	theme	microbial	69:77	arg1	consortia					79:87	gut-derived microbial consortia	57:87	gut-derived microbial consortia	57:87	Structurally complex carbohydrates maintain diversity in gut-derived microbial consortia under high dilution pressure.
32815998	3	49	theme	complex	780:786	arg1	polysaccharide					788:801	a complex polysaccharide	778:801	a complex polysaccharide	778:801	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	49	theme	complex	780:786	arg1	SAX					773:775	SAX	773:775	SAX	773:775	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	4	50	theme	diverse	999:1005	arg1	consortia					1017:1025	diverse microbial consortia	999:1025	diverse microbial consortia	999:1025	Our results demonstrate that complex carbohydrates stably sustain diverse microbial consortia.
32815998	6	51	theme	microbiome	1366:1375	arg1	composition					1377:1387	microbiome composition	1366:1387	microbiome composition	1366:1387	Finally, very similar final consortia were enriched on SAX from the same individual's fecal microbiota one month later, suggesting that polysaccharide structure is more influential than stochastic alterations in microbiome composition in governing the outcomes of sequential batch cultivation experiments.
32815998	7	52	dep	affords	1519:1525	arg1	whereas					1593:1599	whereas	1593:1599	whereas	1593:1599	These data suggest that carbohydrate structural complexity affords independent niches that structure fermenting microbial consortia, whereas other metabolic interactions govern the composition of communities fermenting simpler carbohydrates.
32815998	0	53	theme	gut-derived	57:67	arg1	consortia					79:87	gut-derived microbial consortia	57:87	gut-derived microbial consortia	57:87	Structurally complex carbohydrates maintain diversity in gut-derived microbial consortia under high dilution pressure.
32815998	1	54	theme	major	138:142	arg1	substrates					144:153	major substrates	138:153	major substrates for maintaining and shaping gut microbiota	138:196	Dietary fibers are major substrates for maintaining and shaping gut microbiota, but the structural specificity of these fibers for the diversity, structure and function of gut microbiota are poorly understood.
32815998	1	54	theme	major	138:142	arg1	fibers					127:132	Dietary fibers	119:132	Dietary fibers	119:132	Dietary fibers are major substrates for maintaining and shaping gut microbiota, but the structural specificity of these fibers for the diversity, structure and function of gut microbiota are poorly understood.
32815998	7	55	theme	simpler	1679:1685	arg1	carbohydrates					1687:1699	communities fermenting simpler carbohydrates	1656:1699	communities fermenting simpler carbohydrates	1656:1699	These data suggest that carbohydrate structural complexity affords independent niches that structure fermenting microbial consortia, whereas other metabolic interactions govern the composition of communities fermenting simpler carbohydrates.
32815998	6	56	theme	fecal	1240:1244	arg1	microbiota					1246:1255	the same individual's fecal microbiota	1218:1255	the same individual's fecal microbiota one month later	1218:1271	Finally, very similar final consortia were enriched on SAX from the same individual's fecal microbiota one month later, suggesting that polysaccharide structure is more influential than stochastic alterations in microbiome composition in governing the outcomes of sequential batch cultivation experiments.
32815998	2	57	dep	influences	490:499	arg1	i					437:437	i	437:437	i	437:437	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	2	58	theme	vitamins	695:702	arg1	exchange					668:675	exchange	668:675	exchange of amino acids or vitamins	668:702	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	6	59	theme	final	1176:1180	arg1	consortia					1182:1190	very similar final consortia	1163:1190	very similar final consortia	1163:1190	Finally, very similar final consortia were enriched on SAX from the same individual's fecal microbiota one month later, suggesting that polysaccharide structure is more influential than stochastic alterations in microbiome composition in governing the outcomes of sequential batch cultivation experiments.
32815998	3	60	theme	corresponding	857:869	arg1	carbohydrates					918:930	model carbohydrates	912:930	model carbohydrates	912:930	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	60	theme	corresponding	857:869	arg1	controls					886:893	their corresponding monosaccharide controls	851:893	their corresponding monosaccharide controls	851:893	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	60	theme	corresponding	857:869	arg1	inulin					805:810	inulin	805:810	inulin (a low-complexity oligosaccharide)	805:845	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	3	60	theme	corresponding	857:869	arg1	arabinoxylan					759:770	Sorghum arabinoxylan	751:770	Sorghum arabinoxylan (SAX, a complex polysaccharide)	751:802	Sorghum arabinoxylan (SAX, a complex polysaccharide), inulin (a low-complexity oligosaccharide) and their corresponding monosaccharide controls were selected as model carbohydrates.
32815998	1	61	theme	fibers	239:244	arg1	specificity					218:228	the structural specificity	203:228	the structural specificity of these fibers for the diversity, structure and function of gut microbiota	203:304	Dietary fibers are major substrates for maintaining and shaping gut microbiota, but the structural specificity of these fibers for the diversity, structure and function of gut microbiota are poorly understood.
32815998	2	62	theme	dilution	558:565	arg1	pressure					567:574	high dilution pressure	553:574	high dilution pressure (ii)	553:579	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	2	62	theme	dilution	558:565	arg1	ii					577:578	ii	577:578	ii	577:578	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	5	63	theme	microbial	1107:1115	arg1	consortia					1117:1125	microbial consortia	1107:1125	microbial consortia consuming SAX than inulin	1107:1151	Furthermore, other metabolic interactions were less influential in structuring microbial consortia consuming SAX than inulin.
32815998	6	64	theme	similar	1168:1174	arg1	consortia					1182:1190	very similar final consortia	1163:1190	very similar final consortia	1163:1190	Finally, very similar final consortia were enriched on SAX from the same individual's fecal microbiota one month later, suggesting that polysaccharide structure is more influential than stochastic alterations in microbiome composition in governing the outcomes of sequential batch cultivation experiments.
32815998	4	65	theme	microbial	1007:1015	arg1	consortia					1017:1025	diverse microbial consortia	999:1025	diverse microbial consortia	999:1025	Our results demonstrate that complex carbohydrates stably sustain diverse microbial consortia.
32815998	5	66	theme	other	1041:1045	arg1	interactions					1057:1068	other metabolic interactions	1041:1068	other metabolic interactions	1041:1068	Furthermore, other metabolic interactions were less influential in structuring microbial consortia consuming SAX than inulin.
32815998	2	67	theme	maintained	729:738	arg1	diversity					740:748	maintained diversity	729:748	maintained diversity	729:748	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	2	68	theme	batch	370:374	arg1	approach					390:397	an in vitro sequential batch fecal culture approach	347:397	an in vitro sequential batch fecal culture approach to address two ecological questions	347:433	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	6	69	from	alterations	1351:1361	arg1	composition					1377:1387	microbiome composition	1366:1387	microbiome composition	1366:1387	Finally, very similar final consortia were enriched on SAX from the same individual's fecal microbiota one month later, suggesting that polysaccharide structure is more influential than stochastic alterations in microbiome composition in governing the outcomes of sequential batch cultivation experiments.
32815998	2	70	theme	carbohydrate	477:488	arg1	complexity					461:470	the chemical complexity	448:470	the chemical complexity of a carbohydrate	448:488	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	7	71	theme	other	1601:1605	arg1	interactions					1617:1628	other metabolic interactions	1601:1628	other metabolic interactions	1601:1628	These data suggest that carbohydrate structural complexity affords independent niches that structure fermenting microbial consortia, whereas other metabolic interactions govern the composition of communities fermenting simpler carbohydrates.
32815998	5	72	theme	metabolic	1047:1055	arg1	interactions					1057:1068	other metabolic interactions	1041:1068	other metabolic interactions	1041:1068	Furthermore, other metabolic interactions were less influential in structuring microbial consortia consuming SAX than inulin.
32815998	2	73	theme	sequential	359:368	arg1	approach					390:397	an in vitro sequential batch fecal culture approach	347:397	an in vitro sequential batch fecal culture approach to address two ecological questions	347:433	Here, we employed an in vitro sequential batch fecal culture approach to address two ecological questions: (i) whether the chemical complexity of a carbohydrate influences its ability to maintain microbial diversity against high dilution pressure (ii) whether substrate structuring or obligate microbe-microbe metabolic interactions (e.g. exchange of amino acids or vitamins) exert more influence on maintained diversity.
32815998	6	74	from	microbiota	1246:1255	arg1	SAX					1209:1211	SAX	1209:1211	SAX from the same individual's fecal microbiota one month later	1209:1271	Finally, very similar final consortia were enriched on SAX from the same individual's fecal microbiota one month later, suggesting that polysaccharide structure is more influential than stochastic alterations in microbiome composition in governing the outcomes of sequential batch cultivation experiments.
32815998	6	75	theme	cultivation	1435:1445	arg1	experiments					1447:1457	sequential batch cultivation experiments	1418:1457	sequential batch cultivation experiments	1418:1457	Finally, very similar final consortia were enriched on SAX from the same individual's fecal microbiota one month later, suggesting that polysaccharide structure is more influential than stochastic alterations in microbiome composition in governing the outcomes of sequential batch cultivation experiments.
33411938	4	0	theme	new	587:589	arg1	biomaterials					591:602	new biomaterials	587:602	new biomaterials	587:602	Emerging scaffold-based repair strategies have reported superior outcomes compared to microfracture and motivate the development of new biomaterials for this purpose.
33411938	4	1	contain	have	497:500	arg2	outcomes					520:527	reported superior outcomes	502:527	reported superior outcomes	502:527	Emerging scaffold-based repair strategies have reported superior outcomes compared to microfracture and motivate the development of new biomaterials for this purpose.
33411938	4	1	contain	have	497:500	arg1	strategies					486:495	Emerging scaffold-based repair strategies	455:495	Emerging scaffold-based repair strategies	455:495	Emerging scaffold-based repair strategies have reported superior outcomes compared to microfracture and motivate the development of new biomaterials for this purpose.
33411938	2	2	theme	joint	250:254	arg1	pathologies					256:266	joint pathologies	250:266	joint pathologies	250:266	Chondral defects may arise from a variety of joint pathologies and left untreated, will likely progress to osteoarthritis.
33411938	10	3	theme	care	1641:1644	arg1	standard					1629:1636	standard	1629:1636	standard	1629:1636	Despite positive early findings, the long-term results indicated less than optimal structural and mechanical results with respect to cartilage repair, with all treatment groups performing worse than the standard of care.
33411938	2	4	dep	arise	226:230	arg1	progress					300:307	progress	300:307	will likely progress to osteoarthritis	288:325	Chondral defects may arise from a variety of joint pathologies and left untreated, will likely progress to osteoarthritis.
33411938	10	5	theme	cartilage	1559:1567	arg1	repair					1569:1574	cartilage repair	1559:1574	cartilage repair	1559:1574	Despite positive early findings, the long-term results indicated less than optimal structural and mechanical results with respect to cartilage repair, with all treatment groups performing worse than the standard of care.
33411938	7	6	theme	cartilage-repair	1091:1106	arg1	studies					1108:1114	many cartilage-repair studies	1086:1114	many cartilage-repair studies	1086:1114	While many cartilage-repair studies have shown some success in vivo, most are short term and not clinically relevant.
33411938	11	7	theme	animal	1804:1809	arg1	model					1811:1815	an appropriate animal model	1789:1815	an appropriate animal model	1789:1815	This study is important in that it brings much needed attention to the importance of performing translationally relevant long-term studies in an appropriate animal model when developing new clinical cartilage repair approaches.
33411938	5	8	theme	unique	637:642	arg1	implants					654:661	unique composite implants	637:661	unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate	637:853	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	2	9	theme	untreated	277:285	arg1	variety					239:245	a variety	237:245	a variety of joint pathologies and left untreated	237:285	Chondral defects may arise from a variety of joint pathologies and left untreated, will likely progress to osteoarthritis.
33411938	2	9	theme	untreated	277:285	arg1	pathologies					256:266	joint pathologies	250:266	joint pathologies	250:266	Chondral defects may arise from a variety of joint pathologies and left untreated, will likely progress to osteoarthritis.
33411938	2	9	theme	untreated	277:285	arg1	untreated					277:285	untreated	277:285	untreated	277:285	Chondral defects may arise from a variety of joint pathologies and left untreated, will likely progress to osteoarthritis.
33411938	1	10	theme	issues	168:173	arg1	issues					168:173	the foremost issues	155:173	the foremost issues	155:173	The repair of focal cartilage defects remains one of the foremost issues in the field of orthopaedics.
33411938	1	10	theme	issues	168:173	arg1	one					148:150	one	148:150	one	148:150	The repair of focal cartilage defects remains one of the foremost issues in the field of orthopaedics.
33411938	3	11	contain	have	425:428	arg2	outcomes					445:452	poor long-term outcomes	430:452	poor long-term outcomes	430:452	Current repair techniques, such as microfracture, result in short-term clinical improvements but have poor long-term outcomes.
33411938	3	11	contain	have	425:428	arg1	techniques					343:352	Current repair techniques	328:352	Current repair techniques	328:352	Current repair techniques, such as microfracture, result in short-term clinical improvements but have poor long-term outcomes.
33411938	3	11	contain	have	425:428	arg1	microfracture					363:375	microfracture	363:375	microfracture	363:375	Current repair techniques, such as microfracture, result in short-term clinical improvements but have poor long-term outcomes.
33411938	11	12	theme	new	1833:1835	arg1	approaches					1863:1872	new clinical cartilage repair approaches	1833:1872	new clinical cartilage repair approaches	1833:1872	This study is important in that it brings much needed attention to the importance of performing translationally relevant long-term studies in an appropriate animal model when developing new clinical cartilage repair approaches.
33411938	2	13	theme	Chondral	205:212	arg1	defects					214:220	Chondral defects	205:220	Chondral defects	205:220	Chondral defects may arise from a variety of joint pathologies and left untreated, will likely progress to osteoarthritis.
33411938	5	14	theme	marrow	839:844	arg1	aspirate					846:853	bone marrow aspirate	834:853	bone marrow aspirate	834:853	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	8	15	theme	promising	1210:1218	arg1	findings					1227:1234	promising 6-week findings	1210:1234	promising 6-week findings	1210:1234	Informed by promising 6-week findings, a 12-month study was carried out and those results are presented here.
33411938	5	16	theme	base	679:682	arg1	component					703:711	a base porous reinforcing component	677:711	a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate	677:853	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	6	17	theme	composite	923:931	arg1	treatment					942:950	composite scaffold treatment	923:950	composite scaffold treatment	923:950	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	0	18	from	model	95:99	arg1	repair					43:48	biomaterial-mediated repair	22:48	biomaterial-mediated repair of focal cartilage defects in a large animal model	22:99	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.
33411938	5	19	theme	reinforcing	691:701	arg1	component					703:711	a base porous reinforcing component	677:711	a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate	677:853	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	1	20	theme	focal	116:120	arg1	defects					132:138	focal cartilage defects	116:138	focal cartilage defects	116:138	The repair of focal cartilage defects remains one of the foremost issues in the field of orthopaedics.
33411938	0	21	theme	cartilage	59:67	arg1	defects					69:75	focal cartilage defects	53:75	focal cartilage defects in a large animal model	53:99	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.
33411938	1	22	theme	defects	132:138	arg1	repair					106:111	The repair	102:111	The repair of focal cartilage defects	102:138	The repair of focal cartilage defects remains one of the foremost issues in the field of orthopaedics.
33411938	5	23	dep	component	703:711	arg1	ε-caprolactone					725:738	ε-caprolactone	725:738	ε-caprolactone	725:738	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	5	23	dep	component	703:711	arg1	poly					720:723	woven poly	714:723	woven poly(ε-caprolactone)	714:739	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	10	24	theme	early	1443:1447	arg1	findings					1449:1456	positive early findings	1434:1456	positive early findings	1434:1456	Despite positive early findings, the long-term results indicated less than optimal structural and mechanical results with respect to cartilage repair, with all treatment groups performing worse than the standard of care.
33411938	3	25	theme	Current	328:334	arg1	techniques					343:352	Current repair techniques	328:352	Current repair techniques	328:352	Current repair techniques, such as microfracture, result in short-term clinical improvements but have poor long-term outcomes.
33411938	3	25	theme	Current	328:334	arg1	microfracture					363:375	microfracture	363:375	microfracture	363:375	Current repair techniques, such as microfracture, result in short-term clinical improvements but have poor long-term outcomes.
33411938	4	26	theme	reported	502:509	arg1	outcomes					520:527	reported superior outcomes	502:527	reported superior outcomes	502:527	Emerging scaffold-based repair strategies have reported superior outcomes compared to microfracture and motivate the development of new biomaterials for this purpose.
33411938	11	27	theme	relevant	1759:1766	arg1	studies					1778:1784	translationally relevant long-term studies	1743:1784	translationally relevant long-term studies	1743:1784	This study is important in that it brings much needed attention to the importance of performing translationally relevant long-term studies in an appropriate animal model when developing new clinical cartilage repair approaches.
33411938	0	28	theme	large	82:86	arg1	model					95:99	a large animal model	80:99	a large animal model	80:99	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.
33411938	6	29	from	care	988:991	arg1	model					1052:1056	a translationally relevant large animal model	1012:1056	a translationally relevant large animal model	1012:1056	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	6	29	from	care	988:991	arg1	minipig					1071:1077	the Yucatan minipig	1059:1077	the Yucatan minipig	1059:1077	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	6	30	theme	Yucatan	1063:1069	arg1	model					1052:1056	a translationally relevant large animal model	1012:1056	a translationally relevant large animal model	1012:1056	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	6	30	theme	Yucatan	1063:1069	arg1	minipig					1071:1077	the Yucatan minipig	1059:1077	the Yucatan minipig	1059:1077	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	4	31	theme	scaffold-based	464:477	arg1	strategies					486:495	Emerging scaffold-based repair strategies	455:495	Emerging scaffold-based repair strategies	455:495	Emerging scaffold-based repair strategies have reported superior outcomes compared to microfracture and motivate the development of new biomaterials for this purpose.
33411938	3	32	theme	short-term	388:397	arg1	improvements					408:419	short-term clinical improvements	388:419	short-term clinical improvements	388:419	Current repair techniques, such as microfracture, result in short-term clinical improvements but have poor long-term outcomes.
33411938	0	33	theme	Long	0:3	arg1	outcomes					10:17	Long term outcomes	0:17	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.	0:100	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.
33411938	3	34	theme	long-term	435:443	arg1	outcomes					445:452	poor long-term outcomes	430:452	poor long-term outcomes	430:452	Current repair techniques, such as microfracture, result in short-term clinical improvements but have poor long-term outcomes.
33411938	6	35	theme	animal	1045:1050	arg1	model					1052:1056	a translationally relevant large animal model	1012:1056	a translationally relevant large animal model	1012:1056	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	6	35	theme	animal	1045:1050	arg1	minipig					1071:1077	the Yucatan minipig	1059:1077	the Yucatan minipig	1059:1077	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	0	36	theme	biomaterial-mediated	22:41	arg1	repair					43:48	biomaterial-mediated repair	22:48	biomaterial-mediated repair of focal cartilage defects in a large animal model	22:99	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.
33411938	6	37	theme	relevant	1030:1037	arg1	model					1052:1056	a translationally relevant large animal model	1012:1056	a translationally relevant large animal model	1012:1056	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	6	37	theme	relevant	1030:1037	arg1	minipig					1071:1077	the Yucatan minipig	1059:1077	the Yucatan minipig	1059:1077	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	10	38	theme	mechanical	1524:1533	arg1	results					1535:1541	optimal structural and mechanical results	1501:1541	optimal structural and mechanical results with respect to cartilage repair	1501:1574	Despite positive early findings, the long-term results indicated less than optimal structural and mechanical results with respect to cartilage repair, with all treatment groups performing worse than the standard of care.
33411938	5	39	theme	self-assembling	777:791	arg1	hydrogels					766:774	1 of 2 hydrogels	759:774	1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan)	759:829	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	5	39	theme	self-assembling	777:791	arg1	peptide					793:799	self-assembling peptide	777:799	self-assembling peptide	777:799	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	10	40	theme	structural	1509:1518	arg1	results					1535:1541	optimal structural and mechanical results	1501:1541	optimal structural and mechanical results with respect to cartilage repair	1501:1574	Despite positive early findings, the long-term results indicated less than optimal structural and mechanical results with respect to cartilage repair, with all treatment groups performing worse than the standard of care.
33411938	11	41	theme	cartilage	1846:1854	arg1	repair					1856:1861	clinical cartilage repair	1837:1861	new clinical cartilage repair approaches	1833:1872	This study is important in that it brings much needed attention to the importance of performing translationally relevant long-term studies in an appropriate animal model when developing new clinical cartilage repair approaches.
33411938	9	42	theme	structural	1356:1365	arg1	measures					1401:1408	several structural and functionally relevant outcome measures	1348:1408	several structural and functionally relevant outcome measures	1348:1408	To aid in comparisons across platforms, several structural and functionally relevant outcome measures were performed.
33411938	5	43	theme	composite	644:652	arg1	implants					654:661	unique composite implants	637:661	unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate	637:853	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	9	44	theme	outcome	1393:1399	arg1	measures					1401:1408	several structural and functionally relevant outcome measures	1348:1408	several structural and functionally relevant outcome measures	1348:1408	To aid in comparisons across platforms, several structural and functionally relevant outcome measures were performed.
33411938	6	45	theme	cartilage	901:909	arg1	repair					911:916	cartilage repair	901:916	cartilage repair	901:916	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	2	46	theme	pathologies	256:266	arg1	variety					239:245	a variety	237:245	a variety of joint pathologies and left untreated	237:285	Chondral defects may arise from a variety of joint pathologies and left untreated, will likely progress to osteoarthritis.
33411938	2	46	theme	pathologies	256:266	arg1	pathologies					256:266	joint pathologies	250:266	joint pathologies	250:266	Chondral defects may arise from a variety of joint pathologies and left untreated, will likely progress to osteoarthritis.
33411938	2	46	theme	pathologies	256:266	arg1	untreated					277:285	untreated	277:285	untreated	277:285	Chondral defects may arise from a variety of joint pathologies and left untreated, will likely progress to osteoarthritis.
33411938	4	47	theme	biomaterials	591:602	arg1	development					572:582	the development	568:582	the development of new biomaterials	568:602	Emerging scaffold-based repair strategies have reported superior outcomes compared to microfracture and motivate the development of new biomaterials for this purpose.
33411938	7	48	theme	many	1086:1089	arg1	studies					1108:1114	many cartilage-repair studies	1086:1114	many cartilage-repair studies	1086:1114	While many cartilage-repair studies have shown some success in vivo, most are short term and not clinically relevant.
33411938	8	49	theme	6-week	1220:1225	arg1	findings					1227:1234	promising 6-week findings	1210:1234	promising 6-week findings	1210:1234	Informed by promising 6-week findings, a 12-month study was carried out and those results are presented here.
33411938	1	50	theme	foremost	159:166	arg1	issues					168:173	the foremost issues	155:173	the foremost issues	155:173	The repair of focal cartilage defects remains one of the foremost issues in the field of orthopaedics.
33411938	5	51	dep	hydrogels	766:774	arg1	hydrogels					766:774	1 of 2 hydrogels	759:774	1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan)	759:829	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	5	51	dep	hydrogels	766:774	arg1	peptide					793:799	self-assembling peptide	777:799	self-assembling peptide	777:799	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	5	51	dep	hydrogels	766:774	arg1	hyaluronan					819:828	thermo-gelling hyaluronan	804:828	thermo-gelling hyaluronan	804:828	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	10	52	theme	treatment	1586:1594	arg1	groups					1596:1601	all treatment groups	1582:1601	all treatment groups performing worse than the standard of care	1582:1644	Despite positive early findings, the long-term results indicated less than optimal structural and mechanical results with respect to cartilage repair, with all treatment groups performing worse than the standard of care.
33411938	8	53	theme	12-month	1239:1246	arg1	study					1248:1252	a 12-month study	1237:1252	a 12-month study	1237:1252	Informed by promising 6-week findings, a 12-month study was carried out and those results are presented here.
33411938	11	54	theme	appropriate	1792:1802	arg1	model					1811:1815	an appropriate animal model	1789:1815	an appropriate animal model	1789:1815	This study is important in that it brings much needed attention to the importance of performing translationally relevant long-term studies in an appropriate animal model when developing new clinical cartilage repair approaches.
33411938	5	55	theme	woven	714:718	arg1	ε-caprolactone					725:738	ε-caprolactone	725:738	ε-caprolactone	725:738	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	5	55	theme	woven	714:718	arg1	poly					720:723	woven poly	714:723	woven poly(ε-caprolactone)	714:739	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	5	56	theme	bone	834:837	arg1	aspirate					846:853	bone marrow aspirate	834:853	bone marrow aspirate	834:853	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	0	57	from	defects	69:75	arg1	model					95:99	a large animal model	80:99	a large animal model	80:99	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.
33411938	11	58	theme	clinical	1837:1844	arg1	repair					1856:1861	clinical cartilage repair	1837:1861	new clinical cartilage repair approaches	1833:1872	This study is important in that it brings much needed attention to the importance of performing translationally relevant long-term studies in an appropriate animal model when developing new clinical cartilage repair approaches.
33411938	6	59	theme	scaffold	933:940	arg1	treatment					942:950	composite scaffold treatment	923:950	composite scaffold treatment	923:950	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	5	60	theme	porous	684:689	arg1	component					703:711	a base porous reinforcing component	677:711	a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate	677:853	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	0	61	theme	defects	69:75	arg1	repair					43:48	biomaterial-mediated repair	22:48	biomaterial-mediated repair of focal cartilage defects in a large animal model	22:99	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.
33411938	1	62	theme	cartilage	122:130	arg1	defects					132:138	focal cartilage defects	116:138	focal cartilage defects	116:138	The repair of focal cartilage defects remains one of the foremost issues in the field of orthopaedics.
33411938	1	63	theme	orthopaedics	191:202	arg1	field					182:186	the field	178:186	the field of orthopaedics	178:202	The repair of focal cartilage defects remains one of the foremost issues in the field of orthopaedics.
33411938	4	64	theme	superior	511:518	arg1	outcomes					520:527	reported superior outcomes	502:527	reported superior outcomes	502:527	Emerging scaffold-based repair strategies have reported superior outcomes compared to microfracture and motivate the development of new biomaterials for this purpose.
33411938	10	65	theme	positive	1434:1441	arg1	findings					1449:1456	positive early findings	1434:1456	positive early findings	1434:1456	Despite positive early findings, the long-term results indicated less than optimal structural and mechanical results with respect to cartilage repair, with all treatment groups performing worse than the standard of care.
33411938	0	66	theme	animal	88:93	arg1	model					95:99	a large animal model	80:99	a large animal model	80:99	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.
33411938	6	67	theme	care	988:991	arg1	standard					976:983	standard	976:983	standard	976:983	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	3	68	theme	repair	336:341	arg1	techniques					343:352	Current repair techniques	328:352	Current repair techniques	328:352	Current repair techniques, such as microfracture, result in short-term clinical improvements but have poor long-term outcomes.
33411938	3	68	theme	repair	336:341	arg1	microfracture					363:375	microfracture	363:375	microfracture	363:375	Current repair techniques, such as microfracture, result in short-term clinical improvements but have poor long-term outcomes.
33411938	4	69	theme	Emerging	455:462	arg1	strategies					486:495	Emerging scaffold-based repair strategies	455:495	Emerging scaffold-based repair strategies	455:495	Emerging scaffold-based repair strategies have reported superior outcomes compared to microfracture and motivate the development of new biomaterials for this purpose.
33411938	7	70	dep	term	1164:1167	arg1	short					1158:1162	short	1158:1162	short	1158:1162	While many cartilage-repair studies have shown some success in vivo, most are short term and not clinically relevant.
33411938	11	71	theme	long-term	1768:1776	arg1	studies					1778:1784	translationally relevant long-term studies	1743:1784	translationally relevant long-term studies	1743:1784	This study is important in that it brings much needed attention to the importance of performing translationally relevant long-term studies in an appropriate animal model when developing new clinical cartilage repair approaches.
33411938	0	72	from	repair	43:48	arg1	model					95:99	a large animal model	80:99	a large animal model	80:99	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.
33411938	0	73	theme	term	5:8	arg1	outcomes					10:17	Long term outcomes	0:17	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.	0:100	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.
33411938	10	74	theme	long-term	1463:1471	arg1	results					1473:1479	the long-term results	1459:1479	the long-term results	1459:1479	Despite positive early findings, the long-term results indicated less than optimal structural and mechanical results with respect to cartilage repair, with all treatment groups performing worse than the standard of care.
33411938	3	75	theme	clinical	399:406	arg1	improvements					408:419	short-term clinical improvements	388:419	short-term clinical improvements	388:419	Current repair techniques, such as microfracture, result in short-term clinical improvements but have poor long-term outcomes.
33411938	5	76	theme	thermo-gelling	804:817	arg1	hydrogels					766:774	1 of 2 hydrogels	759:774	1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan)	759:829	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	5	76	theme	thermo-gelling	804:817	arg1	hyaluronan					819:828	thermo-gelling hyaluronan	804:828	thermo-gelling hyaluronan	804:828	In this study, unique composite implants consisting of a base porous reinforcing component (woven poly(ε-caprolactone)) infiltrated with 1 of 2 hydrogels (self-assembling peptide or thermo-gelling hyaluronan) or bone marrow aspirate were evaluated.
33411938	0	77	theme	repair	43:48	arg1	outcomes					10:17	Long term outcomes	0:17	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.	0:100	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.
33411938	6	78	theme	large	1039:1043	arg1	model					1052:1056	a translationally relevant large animal model	1012:1056	a translationally relevant large animal model	1012:1056	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	6	78	theme	large	1039:1043	arg1	minipig					1071:1077	the Yucatan minipig	1059:1077	the Yucatan minipig	1059:1077	The objective was to evaluate cartilage repair with composite scaffold treatment compared to the current standard of care (microfracture) in a translationally relevant large animal model, the Yucatan minipig.
33411938	3	79	theme	poor	430:433	arg1	outcomes					445:452	poor long-term outcomes	430:452	poor long-term outcomes	430:452	Current repair techniques, such as microfracture, result in short-term clinical improvements but have poor long-term outcomes.
33411938	0	80	theme	focal	53:57	arg1	defects					69:75	focal cartilage defects	53:75	focal cartilage defects in a large animal model	53:99	Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.
33411938	4	81	theme	repair	479:484	arg1	strategies					486:495	Emerging scaffold-based repair strategies	455:495	Emerging scaffold-based repair strategies	455:495	Emerging scaffold-based repair strategies have reported superior outcomes compared to microfracture and motivate the development of new biomaterials for this purpose.
33411938	9	82	theme	several	1348:1354	arg1	measures					1401:1408	several structural and functionally relevant outcome measures	1348:1408	several structural and functionally relevant outcome measures	1348:1408	To aid in comparisons across platforms, several structural and functionally relevant outcome measures were performed.
33411938	10	83	theme	optimal	1501:1507	arg1	results					1535:1541	optimal structural and mechanical results	1501:1541	optimal structural and mechanical results with respect to cartilage repair	1501:1574	Despite positive early findings, the long-term results indicated less than optimal structural and mechanical results with respect to cartilage repair, with all treatment groups performing worse than the standard of care.
33411938	11	84	theme	needed	1694:1699	arg1	attention					1701:1709	much needed attention	1689:1709	much needed attention to the importance of performing translationally relevant long-term studies in an appropriate animal model	1689:1815	This study is important in that it brings much needed attention to the importance of performing translationally relevant long-term studies in an appropriate animal model when developing new clinical cartilage repair approaches.
33411938	11	85	theme	repair	1856:1861	arg1	approaches					1863:1872	new clinical cartilage repair approaches	1833:1872	new clinical cartilage repair approaches	1833:1872	This study is important in that it brings much needed attention to the importance of performing translationally relevant long-term studies in an appropriate animal model when developing new clinical cartilage repair approaches.
33411938	9	86	theme	relevant	1384:1391	arg1	measures					1401:1408	several structural and functionally relevant outcome measures	1348:1408	several structural and functionally relevant outcome measures	1348:1408	To aid in comparisons across platforms, several structural and functionally relevant outcome measures were performed.
32718597	4	0	theme	5	707:707	arg1	%					708:708	%	708:708	%	708:708	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	1	1	theme	materials	162:170	arg1	preparation					137:147	The preparation	133:147	The preparation of polymeric materials with high performance and functional performance	133:219	The preparation of polymeric materials with high performance and functional performance remains a focus of extensive research.
32718597	6	2	theme	shape	983:987	arg1	behavior					996:1003	a tunable water-induced shape memory behavior	959:1003	a tunable water-induced shape memory behavior	959:1003	Moreover, this achieved a tunable water-induced shape memory behavior at different pH environments.
32718597	0	3	theme	mechanical	71:80	arg1	properties					82:91	excellent mechanical properties	61:91	excellent mechanical properties	61:91	Co-precipitated poly(vinyl alcohol)/chitosan composites with excellent mechanical properties and tunable water-induced shape memory.
32718597	6	4	theme	water-induced	969:981	arg1	behavior					996:1003	a tunable water-induced shape memory behavior	959:1003	a tunable water-induced shape memory behavior	959:1003	Moreover, this achieved a tunable water-induced shape memory behavior at different pH environments.
32718597	0	5	theme	tunable	97:103	arg1	memory					125:130	tunable water-induced shape memory	97:130	tunable water-induced shape memory	97:130	Co-precipitated poly(vinyl alcohol)/chitosan composites with excellent mechanical properties and tunable water-induced shape memory.
32718597	5	6	theme	PVA/RCS	852:858	arg1	composites					860:869	the fabricated PVA/RCS composites	837:869	the fabricated PVA/RCS composites	837:869	Intriguingly, the fabricated PVA/RCS composites exhibited good pH-sensitivity due to internal hydrogen bonding.
32718597	6	7	theme	tunable	961:967	arg1	behavior					996:1003	a tunable water-induced shape memory behavior	959:1003	a tunable water-induced shape memory behavior	959:1003	Moreover, this achieved a tunable water-induced shape memory behavior at different pH environments.
32718597	7	8	theme	renewable	1091:1099	arg1	polysaccharide					1101:1114	renewable polysaccharide	1091:1114	renewable polysaccharide	1091:1114	This study provides a promising strategy for the use of renewable polysaccharide to achieve high performance and functionality of polymer materials.
32718597	2	9	from	poly	330:333	arg1	dispersion					282:291	a good dispersion	275:291	a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding	275:445	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	10	theme	vinyl	335:339	arg1	poly					330:333	the poly	326:333	the poly(vinyl alcohol) (PVA)	326:354	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	10	theme	vinyl	335:339	arg1	alcohol					341:347	vinyl alcohol	335:347	vinyl alcohol	335:347	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	11	theme	molecular	396:404	arg1	entanglements					412:424	molecular chain entanglements	396:424	molecular chain entanglements	396:424	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	0	12	theme	shape	119:123	arg1	memory					125:130	tunable water-induced shape memory	97:130	tunable water-induced shape memory	97:130	Co-precipitated poly(vinyl alcohol)/chitosan composites with excellent mechanical properties and tunable water-induced shape memory.
32718597	3	13	from	increase	602:609	arg1	properties					629:638	the mechanical properties	614:638	the mechanical properties	614:638	Dynamic mechanical analysis and tensile tests demonstrated that RCS achieved a significant increase in the mechanical properties.
32718597	2	14	theme	good	277:280	arg1	dispersion					282:291	a good dispersion	275:291	a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding	275:445	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	1	15	theme	high	177:180	arg1	performance					182:192	high performance	177:192	high performance	177:192	The preparation of polymeric materials with high performance and functional performance remains a focus of extensive research.
32718597	0	16	theme	water-induced	105:117	arg1	memory					125:130	tunable water-induced shape memory	97:130	tunable water-induced shape memory	97:130	Co-precipitated poly(vinyl alcohol)/chitosan composites with excellent mechanical properties and tunable water-induced shape memory.
32718597	1	17	with	preparation	137:147	arg1	performance					182:192	high performance	177:192	high performance	177:192	The preparation of polymeric materials with high performance and functional performance remains a focus of extensive research.
32718597	1	17	with	preparation	137:147	arg1	performance					209:219	functional performance	198:219	functional performance	198:219	The preparation of polymeric materials with high performance and functional performance remains a focus of extensive research.
32718597	7	18	theme	promising	1057:1065	arg1	strategy					1067:1074	a promising strategy	1055:1074	a promising strategy for the use of renewable polysaccharide to achieve high performance and functionality of polymer materials	1055:1181	This study provides a promising strategy for the use of renewable polysaccharide to achieve high performance and functionality of polymer materials.
32718597	3	19	theme	mechanical	519:528	arg1	analysis					530:537	Dynamic mechanical analysis	511:537	Dynamic mechanical analysis	511:537	Dynamic mechanical analysis and tensile tests demonstrated that RCS achieved a significant increase in the mechanical properties.
32718597	7	20	theme	materials	1173:1181	arg1	performance					1132:1142	high performance	1127:1142	high performance	1127:1142	This study provides a promising strategy for the use of renewable polysaccharide to achieve high performance and functionality of polymer materials.
32718597	7	20	theme	materials	1173:1181	arg1	functionality					1148:1160	functionality	1148:1160	functionality	1148:1160	This study provides a promising strategy for the use of renewable polysaccharide to achieve high performance and functionality of polymer materials.
32718597	2	21	theme	entanglements	412:424	arg1	chitosan					308:315	regenerated chitosan	296:315	regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA)	296:354	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	21	theme	entanglements	412:424	arg1	RCS					318:320	RCS	318:320	RCS	318:320	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	21	theme	entanglements	412:424	arg1	network					385:391	a physical cross-linking network	360:391	a physical cross-linking network of molecular chain entanglements and hydrogen bonding	360:445	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	4	22	theme	PVA	818:820	arg1	MPa					789:791	3416 MPa	784:791	3416 MPa	784:791	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	4	22	theme	PVA	818:820	arg1	MPa					802:804	60.2 MPa	797:804	60.2 MPa	797:804	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	5	23	theme	internal	908:915	arg1	bonding					926:932	internal hydrogen bonding	908:932	internal hydrogen bonding	908:932	Intriguingly, the fabricated PVA/RCS composites exhibited good pH-sensitivity due to internal hydrogen bonding.
32718597	7	24	theme	polymer	1165:1171	arg1	materials					1173:1181	polymer materials	1165:1181	polymer materials	1165:1181	This study provides a promising strategy for the use of renewable polysaccharide to achieve high performance and functionality of polymer materials.
32718597	2	25	theme	chain	406:410	arg1	entanglements					412:424	molecular chain entanglements	396:424	molecular chain entanglements	396:424	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	4	26	theme	pure	813:816	arg1	PVA					818:820	the pure PVA	809:820	the pure PVA	809:820	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	5	27	theme	hydrogen	917:924	arg1	bonding					926:932	internal hydrogen bonding	908:932	internal hydrogen bonding	908:932	Intriguingly, the fabricated PVA/RCS composites exhibited good pH-sensitivity due to internal hydrogen bonding.
32718597	1	28	theme	functional	198:207	arg1	performance					209:219	functional performance	198:219	functional performance	198:219	The preparation of polymeric materials with high performance and functional performance remains a focus of extensive research.
32718597	0	29	theme	vinyl	21:25	arg1	alcohol					27:33	vinyl alcohol	21:33	vinyl alcohol	21:33	Co-precipitated poly(vinyl alcohol)/chitosan composites with excellent mechanical properties and tunable water-induced shape memory.
32718597	7	30	theme	polysaccharide	1101:1114	arg1	use					1084:1086	the use	1080:1086	the use of renewable polysaccharide to achieve high performance and functionality of polymer materials	1080:1181	This study provides a promising strategy for the use of renewable polysaccharide to achieve high performance and functionality of polymer materials.
32718597	2	31	theme	chitosan	308:315	arg1	dispersion					282:291	a good dispersion	275:291	a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding	275:445	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	32	theme	network	385:391	arg1	dispersion					282:291	a good dispersion	275:291	a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding	275:445	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	3	33	theme	Dynamic	511:517	arg1	analysis					530:537	Dynamic mechanical analysis	511:537	Dynamic mechanical analysis	511:537	Dynamic mechanical analysis and tensile tests demonstrated that RCS achieved a significant increase in the mechanical properties.
32718597	2	34	theme	regenerated	296:306	arg1	chitosan					308:315	regenerated chitosan	296:315	regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA)	296:354	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	34	theme	regenerated	296:306	arg1	RCS					318:320	RCS	318:320	RCS	318:320	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	35	theme	cross-linking	371:383	arg1	network					385:391	a physical cross-linking network	360:391	a physical cross-linking network of molecular chain entanglements and hydrogen bonding	360:445	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	4	36	theme	storage	645:651	arg1	modulus					653:659	storage modulus	645:659	storage modulus	645:659	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	4	37	theme	tensile	665:671	arg1	strength					673:680	tensile strength	665:680	tensile strength	665:680	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	2	38	theme	physical	362:369	arg1	network					385:391	a physical cross-linking network	360:391	a physical cross-linking network of molecular chain entanglements and hydrogen bonding	360:445	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	39	theme	bonding	439:445	arg1	chitosan					308:315	regenerated chitosan	296:315	regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA)	296:354	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	39	theme	bonding	439:445	arg1	RCS					318:320	RCS	318:320	RCS	318:320	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	39	theme	bonding	439:445	arg1	network					385:391	a physical cross-linking network	360:391	a physical cross-linking network of molecular chain entanglements and hydrogen bonding	360:445	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	0	40	dep	/chitosan	35:43	arg1	alcohol					27:33	vinyl alcohol	21:33	vinyl alcohol	21:33	Co-precipitated poly(vinyl alcohol)/chitosan composites with excellent mechanical properties and tunable water-induced shape memory.
32718597	4	41	dep	MPa	789:791	arg1	the					780:782	the	780:782	the	780:782	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	2	42	theme	hydrogen	430:437	arg1	bonding					439:445	hydrogen bonding	430:445	hydrogen bonding	430:445	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	5	43	theme	fabricated	841:850	arg1	composites					860:869	the fabricated PVA/RCS composites	837:869	the fabricated PVA/RCS composites	837:869	Intriguingly, the fabricated PVA/RCS composites exhibited good pH-sensitivity due to internal hydrogen bonding.
32718597	5	44	theme	good	881:884	arg1	pH-sensitivity					886:899	good pH-sensitivity	881:899	good pH-sensitivity due to internal hydrogen bonding	881:932	Intriguingly, the fabricated PVA/RCS composites exhibited good pH-sensitivity due to internal hydrogen bonding.
32718597	0	45	theme	/chitosan	35:43	arg1	composites					45:54	poly(vinyl alcohol)/chitosan composites	16:54	poly(vinyl alcohol)/chitosan composites	16:54	Co-precipitated poly(vinyl alcohol)/chitosan composites with excellent mechanical properties and tunable water-induced shape memory.
32718597	4	46	theme	%	708:708	arg1	RCS					710:712	5% RCS	707:712	5% RCS	707:712	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	7	47	theme	high	1127:1130	arg1	performance					1132:1142	high performance	1127:1142	high performance	1127:1142	This study provides a promising strategy for the use of renewable polysaccharide to achieve high performance and functionality of polymer materials.
32718597	3	48	theme	significant	590:600	arg1	increase					602:609	a significant increase	588:609	a significant increase in the mechanical properties	588:638	Dynamic mechanical analysis and tensile tests demonstrated that RCS achieved a significant increase in the mechanical properties.
32718597	5	49	theme	due	901:903	arg1	pH-sensitivity					886:899	good pH-sensitivity	881:899	good pH-sensitivity due to internal hydrogen bonding	881:932	Intriguingly, the fabricated PVA/RCS composites exhibited good pH-sensitivity due to internal hydrogen bonding.
32718597	3	50	theme	tensile	543:549	arg1	tests					551:555	tensile tests	543:555	tensile tests	543:555	Dynamic mechanical analysis and tensile tests demonstrated that RCS achieved a significant increase in the mechanical properties.
32718597	6	51	theme	different	1008:1016	arg1	environments					1021:1032	different pH environments	1008:1032	different pH environments	1008:1032	Moreover, this achieved a tunable water-induced shape memory behavior at different pH environments.
32718597	3	52	theme	mechanical	618:627	arg1	properties					629:638	the mechanical properties	614:638	the mechanical properties	614:638	Dynamic mechanical analysis and tensile tests demonstrated that RCS achieved a significant increase in the mechanical properties.
32718597	4	53	dep	MPa	724:726	arg1	higher					768:773	higher	768:773	higher	768:773	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	1	54	theme	extensive	240:248	arg1	research					250:257	extensive research	240:257	extensive research	240:257	The preparation of polymeric materials with high performance and functional performance remains a focus of extensive research.
32718597	0	55	theme	excellent	61:69	arg1	properties					82:91	excellent mechanical properties	61:91	excellent mechanical properties	61:91	Co-precipitated poly(vinyl alcohol)/chitosan composites with excellent mechanical properties and tunable water-induced shape memory.
32718597	6	56	theme	pH	1018:1019	arg1	environments					1021:1032	different pH environments	1008:1032	different pH environments	1008:1032	Moreover, this achieved a tunable water-induced shape memory behavior at different pH environments.
32718597	4	57	theme	composites	685:694	arg1	modulus					653:659	storage modulus	645:659	storage modulus	645:659	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	4	57	theme	composites	685:694	arg1	strength					673:680	tensile strength	665:680	tensile strength	665:680	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	2	58	from	dispersion	282:291	arg1	poly					330:333	the poly	326:333	the poly(vinyl alcohol) (PVA)	326:354	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	58	from	dispersion	282:291	arg1	alcohol					341:347	vinyl alcohol	335:347	vinyl alcohol	335:347	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	58	from	dispersion	282:291	arg1	PVA					351:353	PVA	351:353	PVA	351:353	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	1	59	theme	research	250:257	arg1	focus					231:235	a focus	229:235	a focus of extensive research	229:257	The preparation of polymeric materials with high performance and functional performance remains a focus of extensive research.
32718597	2	60	theme	unique	464:469	arg1	co-precipitation					471:486	unique co-precipitation	464:486	unique co-precipitation to prepare composites	464:508	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	4	61	contain	containing	696:705	arg2	RCS					710:712	5% RCS	707:712	5% RCS	707:712	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	4	61	contain	containing	696:705	arg1	composites					685:694	composites	685:694	composites containing 5% RCS	685:712	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	4	62	dep	modulus	653:659	arg1	The					641:643	The	641:643	The	641:643	The storage modulus and tensile strength of composites containing 5% RCS were 5205 MPa and 105.7 MPa, which were significantly higher than the 3416 MPa and 60.2 MPa of the pure PVA.
32718597	2	63	from	network	385:391	arg1	poly					330:333	the poly	326:333	the poly(vinyl alcohol) (PVA)	326:354	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	63	from	network	385:391	arg1	alcohol					341:347	vinyl alcohol	335:347	vinyl alcohol	335:347	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	63	from	network	385:391	arg1	PVA					351:353	PVA	351:353	PVA	351:353	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	1	64	theme	polymeric	152:160	arg1	materials					162:170	polymeric materials	152:170	polymeric materials	152:170	The preparation of polymeric materials with high performance and functional performance remains a focus of extensive research.
32718597	2	65	from	chitosan	308:315	arg1	poly					330:333	the poly	326:333	the poly(vinyl alcohol) (PVA)	326:354	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	65	from	chitosan	308:315	arg1	alcohol					341:347	vinyl alcohol	335:347	vinyl alcohol	335:347	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	2	65	from	chitosan	308:315	arg1	PVA					351:353	PVA	351:353	PVA	351:353	In this paper, a good dispersion of regenerated chitosan (RCS) in the poly(vinyl alcohol) (PVA) and a physical cross-linking network of molecular chain entanglements and hydrogen bonding were realized by unique co-precipitation to prepare composites.
32718597	6	66	theme	memory	989:994	arg1	behavior					996:1003	a tunable water-induced shape memory behavior	959:1003	a tunable water-induced shape memory behavior	959:1003	Moreover, this achieved a tunable water-induced shape memory behavior at different pH environments.
31492360	0	0	theme	Spherical	49:57	arg1	Nanocomposites					59:72	Spherical Nanocomposites	49:72	Spherical Nanocomposites	49:72	Removal of Pb(II) Ions from Aqueous Solutions by Spherical Nanocomposites Synthesized Through Immobilization of Paecilomyces lilacinus in Silica Nanoparticles Coated with Ca-Alginate.
31492360	1	1	theme	high	359:362	arg1	efficiency					364:373	their high efficiency	353:373	their high efficiency for removing Pb(II) ions	353:398	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	4	2	theme	silica	814:819	arg1	nanoparticles					821:833	silica nanoparticles	814:833	silica nanoparticles	814:833	For comparison, the adsorption capacity of Pb(II) by another type of microbial composites, namely, P. lilacinus-Cal-Alg beads, without addition of silica nanoparticles, was also studied in parallel.
31492360	6	3	theme	excellent	1040:1048	arg1	efficiency					1058:1067	an excellent removal efficiency	1037:1067	an excellent removal efficiency of Pb(II) in aqueous solution (85.54%)	1037:1106	The results showed that an excellent removal efficiency of Pb(II) in aqueous solution (85.54%) was obtained at initial concentration of 200 mg/L by using the P. lilacinus-SN-Cal-Alg beads.
31492360	5	4	theme	adsorption	991:1000	arg1	mechanism					1002:1010	adsorption mechanism	991:1010	adsorption mechanism	991:1010	Lastly, the equilibrium data in adsorption process were examined by both Langmuir and Freundlich isotherm models to evaluate adsorption mechanism.
31492360	1	5	theme	Paecilomyces	239:250	arg1	"					304:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads"	206:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg)	206:330	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	1	5	theme	Paecilomyces	239:250	arg1	lilacinus-SN-Cal-Alg					310:329	P. lilacinus-SN-Cal-Alg	307:329	P. lilacinus-SN-Cal-Alg	307:329	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	2	6	theme	Pb	503:504	arg1	adsorption					489:498	the adsorption	485:498	the adsorption of Pb(II)	485:508	P. lilacinus-SN-Cal-Alg beads before and after the adsorption of Pb(II) were characterized by FT-IR, SEM-EDS, and XPS analyses.
31492360	6	7	theme	lilacinus-SN-Cal-Alg	1174:1193	arg1	beads					1195:1199	the P. lilacinus-SN-Cal-Alg beads	1167:1199	the P. lilacinus-SN-Cal-Alg beads	1167:1199	The results showed that an excellent removal efficiency of Pb(II) in aqueous solution (85.54%) was obtained at initial concentration of 200 mg/L by using the P. lilacinus-SN-Cal-Alg beads.
31492360	1	8	theme	lilacinus-silica	252:267	arg1	"					304:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads"	206:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg)	206:330	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	1	8	theme	lilacinus-silica	252:267	arg1	lilacinus-SN-Cal-Alg					310:329	P. lilacinus-SN-Cal-Alg	307:329	P. lilacinus-SN-Cal-Alg	307:329	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	8	9	theme	P.	1329:1330	arg1	beads					1353:1357	P. lilacinus-SN-Cal-Alg beads	1329:1357	P. lilacinus-SN-Cal-Alg beads	1329:1357	The adsorption process by P. lilacinus-SN-Cal-Alg beads was best described by the Langmuir model indicating that monolayer adsorption of Pb(II) ions takes place on the beads surfaces and showed that its maximum adsorption capacity was 282.49 mg/g.
31492360	5	10	theme	adsorption	898:907	arg1	process					909:915	adsorption process	898:915	adsorption process	898:915	Lastly, the equilibrium data in adsorption process were examined by both Langmuir and Freundlich isotherm models to evaluate adsorption mechanism.
31492360	3	11	theme	aqueous	649:655	arg1	solution					657:664	aqueous solution	649:664	aqueous solution	649:664	The adsorption capacity of Pb(II) by P. lilacinus-SN-Cal-Alg beads was analyzed in aqueous solution.
31492360	1	12	theme	nanoparticlescalcium-alginate	269:297	arg1	"					304:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads"	206:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg)	206:330	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	1	12	theme	nanoparticlescalcium-alginate	269:297	arg1	lilacinus-SN-Cal-Alg					310:329	P. lilacinus-SN-Cal-Alg	307:329	P. lilacinus-SN-Cal-Alg	307:329	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	8	13	theme	maximum	1506:1512	arg1	capacity					1525:1532	its maximum adsorption capacity	1502:1532	its maximum adsorption capacity	1502:1532	The adsorption process by P. lilacinus-SN-Cal-Alg beads was best described by the Langmuir model indicating that monolayer adsorption of Pb(II) ions takes place on the beads surfaces and showed that its maximum adsorption capacity was 282.49 mg/g.
31492360	1	14	theme	removing	379:386	arg1	ions					395:398	removing Pb(II) ions	379:398	removing Pb(II) ions	379:398	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	4	15	theme	nanoparticles	821:833	arg1	addition					802:809	addition	802:809	addition of silica nanoparticles	802:833	For comparison, the adsorption capacity of Pb(II) by another type of microbial composites, namely, P. lilacinus-Cal-Alg beads, without addition of silica nanoparticles, was also studied in parallel.
31492360	1	16	theme	beads	299:303	arg1	"					304:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads"	206:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg)	206:330	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	1	16	theme	beads	299:303	arg1	lilacinus-SN-Cal-Alg					310:329	P. lilacinus-SN-Cal-Alg	307:329	P. lilacinus-SN-Cal-Alg	307:329	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	1	17	theme	Pb	388:389	arg1	ions					395:398	removing Pb(II) ions	379:398	removing Pb(II) ions	379:398	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	6	18	theme	P.	1171:1172	arg1	beads					1195:1199	the P. lilacinus-SN-Cal-Alg beads	1167:1199	the P. lilacinus-SN-Cal-Alg beads	1167:1199	The results showed that an excellent removal efficiency of Pb(II) in aqueous solution (85.54%) was obtained at initial concentration of 200 mg/L by using the P. lilacinus-SN-Cal-Alg beads.
31492360	4	19	dep	studied	845:851	arg1	II					713:714	II	713:714	II	713:714	For comparison, the adsorption capacity of Pb(II) by another type of microbial composites, namely, P. lilacinus-Cal-Alg beads, without addition of silica nanoparticles, was also studied in parallel.
31492360	7	20	theme	lilacinus-Cal-Alg	1278:1294	arg1	beads					1296:1300	P. lilacinus-Cal-Alg beads	1275:1300	P. lilacinus-Cal-Alg beads	1275:1300	Meanwhile, they exhibited the better adsorption capacity for Pb(II) than P. lilacinus-Cal-Alg beads.
31492360	1	21	theme	II	391:392	arg1	ions					395:398	removing Pb(II) ions	379:398	removing Pb(II) ions	379:398	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	4	22	dep	beads	787:791	arg1	P.					766:767	P.	766:767	P.	766:767	For comparison, the adsorption capacity of Pb(II) by another type of microbial composites, namely, P. lilacinus-Cal-Alg beads, without addition of silica nanoparticles, was also studied in parallel.
31492360	4	23	theme	Pb	710:711	arg1	capacity					698:705	the adsorption capacity	683:705	the adsorption capacity of Pb	683:711	For comparison, the adsorption capacity of Pb(II) by another type of microbial composites, namely, P. lilacinus-Cal-Alg beads, without addition of silica nanoparticles, was also studied in parallel.
31492360	8	24	theme	Pb	1440:1441	arg1	ions					1447:1450	Pb(II) ions	1440:1450	Pb(II) ions	1440:1450	The adsorption process by P. lilacinus-SN-Cal-Alg beads was best described by the Langmuir model indicating that monolayer adsorption of Pb(II) ions takes place on the beads surfaces and showed that its maximum adsorption capacity was 282.49 mg/g.
31492360	7	25	theme	better	1232:1237	arg1	capacity					1250:1257	the better adsorption capacity	1228:1257	the better adsorption capacity for Pb(II)	1228:1268	Meanwhile, they exhibited the better adsorption capacity for Pb(II) than P. lilacinus-Cal-Alg beads.
31492360	5	26	theme	equilibrium	878:888	arg1	data					890:893	the equilibrium data	874:893	the equilibrium data in adsorption process	874:915	Lastly, the equilibrium data in adsorption process were examined by both Langmuir and Freundlich isotherm models to evaluate adsorption mechanism.
31492360	7	27	theme	adsorption	1239:1248	arg1	capacity					1250:1257	the better adsorption capacity	1228:1257	the better adsorption capacity for Pb(II)	1228:1268	Meanwhile, they exhibited the better adsorption capacity for Pb(II) than P. lilacinus-Cal-Alg beads.
31492360	2	28	theme	lilacinus-SN-Cal-Alg	441:460	arg1	beads					462:466	P. lilacinus-SN-Cal-Alg beads	438:466	P. lilacinus-SN-Cal-Alg beads before and after the adsorption of Pb(II)	438:508	P. lilacinus-SN-Cal-Alg beads before and after the adsorption of Pb(II) were characterized by FT-IR, SEM-EDS, and XPS analyses.
31492360	8	29	theme	ions	1447:1450	arg1	adsorption					1426:1435	monolayer adsorption	1416:1435	monolayer adsorption of Pb(II) ions	1416:1450	The adsorption process by P. lilacinus-SN-Cal-Alg beads was best described by the Langmuir model indicating that monolayer adsorption of Pb(II) ions takes place on the beads surfaces and showed that its maximum adsorption capacity was 282.49 mg/g.
31492360	0	30	theme	Paecilomyces	112:123	arg1	lilacinus					125:133	Paecilomyces lilacinus	112:133	Paecilomyces lilacinus	112:133	Removal of Pb(II) Ions from Aqueous Solutions by Spherical Nanocomposites Synthesized Through Immobilization of Paecilomyces lilacinus in Silica Nanoparticles Coated with Ca-Alginate.
31492360	7	31	theme	P.	1275:1276	arg1	beads					1296:1300	P. lilacinus-Cal-Alg beads	1275:1300	P. lilacinus-Cal-Alg beads	1275:1300	Meanwhile, they exhibited the better adsorption capacity for Pb(II) than P. lilacinus-Cal-Alg beads.
31492360	6	32	theme	mg/L	1153:1156	arg1	concentration					1132:1144	initial concentration	1124:1144	initial concentration of 200 mg/L	1124:1156	The results showed that an excellent removal efficiency of Pb(II) in aqueous solution (85.54%) was obtained at initial concentration of 200 mg/L by using the P. lilacinus-SN-Cal-Alg beads.
31492360	1	33	theme	present	191:197	arg1	study					199:203	the present study	187:203	the present study	187:203	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	0	34	theme	Pb	11:12	arg1	Ions					18:21	Pb(II) Ions	11:21	Pb(II) Ions	11:21	Removal of Pb(II) Ions from Aqueous Solutions by Spherical Nanocomposites Synthesized Through Immobilization of Paecilomyces lilacinus in Silica Nanoparticles Coated with Ca-Alginate.
31492360	1	35	theme	P.	307:308	arg1	"					304:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads"	206:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg)	206:330	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	1	35	theme	P.	307:308	arg1	lilacinus-SN-Cal-Alg					310:329	P. lilacinus-SN-Cal-Alg	307:329	P. lilacinus-SN-Cal-Alg	307:329	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	3	36	theme	lilacinus-SN-Cal-Alg	606:625	arg1	beads					627:631	P. lilacinus-SN-Cal-Alg beads	603:631	P. lilacinus-SN-Cal-Alg beads	603:631	The adsorption capacity of Pb(II) by P. lilacinus-SN-Cal-Alg beads was analyzed in aqueous solution.
31492360	6	37	theme	aqueous	1082:1088	arg1	solution					1090:1097	aqueous solution	1082:1097	aqueous solution (85.54%)	1082:1106	The results showed that an excellent removal efficiency of Pb(II) in aqueous solution (85.54%) was obtained at initial concentration of 200 mg/L by using the P. lilacinus-SN-Cal-Alg beads.
31492360	6	37	theme	aqueous	1082:1088	arg1	%					1105:1105	85.54%	1100:1105	85.54%	1100:1105	The results showed that an excellent removal efficiency of Pb(II) in aqueous solution (85.54%) was obtained at initial concentration of 200 mg/L by using the P. lilacinus-SN-Cal-Alg beads.
31492360	8	38	theme	adsorption	1514:1523	arg1	capacity					1525:1532	its maximum adsorption capacity	1502:1532	its maximum adsorption capacity	1502:1532	The adsorption process by P. lilacinus-SN-Cal-Alg beads was best described by the Langmuir model indicating that monolayer adsorption of Pb(II) ions takes place on the beads surfaces and showed that its maximum adsorption capacity was 282.49 mg/g.
31492360	5	39	theme	Freundlich	952:961	arg1	models					972:977	both Langmuir and Freundlich isotherm models	934:977	models	972:977	Lastly, the equilibrium data in adsorption process were examined by both Langmuir and Freundlich isotherm models to evaluate adsorption mechanism.
31492360	8	40	theme	beads	1471:1475	arg1	surfaces					1477:1484	the beads surfaces	1467:1484	the beads surfaces	1467:1484	The adsorption process by P. lilacinus-SN-Cal-Alg beads was best described by the Langmuir model indicating that monolayer adsorption of Pb(II) ions takes place on the beads surfaces and showed that its maximum adsorption capacity was 282.49 mg/g.
31492360	0	41	theme	lilacinus	125:133	arg1	Immobilization					94:107	Immobilization	94:107	Immobilization of Paecilomyces lilacinus in Silica Nanoparticles Coated with Ca-Alginate	94:181	Removal of Pb(II) Ions from Aqueous Solutions by Spherical Nanocomposites Synthesized Through Immobilization of Paecilomyces lilacinus in Silica Nanoparticles Coated with Ca-Alginate.
31492360	0	42	from	Solutions	36:44	arg1	Removal					0:6	Removal	0:6	Removal of Pb(II) Ions from Aqueous Solutions by Spherical Nanocomposites	0:72	Removal of Pb(II) Ions from Aqueous Solutions by Spherical Nanocomposites Synthesized Through Immobilization of Paecilomyces lilacinus in Silica Nanoparticles Coated with Ca-Alginate.
31492360	5	43	theme	isotherm	963:970	arg1	models					972:977	both Langmuir and Freundlich isotherm models	934:977	models	972:977	Lastly, the equilibrium data in adsorption process were examined by both Langmuir and Freundlich isotherm models to evaluate adsorption mechanism.
31492360	8	44	theme	Langmuir	1385:1392	arg1	model					1394:1398	the Langmuir model	1381:1398	the Langmuir model	1381:1398	The adsorption process by P. lilacinus-SN-Cal-Alg beads was best described by the Langmuir model indicating that monolayer adsorption of Pb(II) ions takes place on the beads surfaces and showed that its maximum adsorption capacity was 282.49 mg/g.
31492360	3	45	theme	P.	603:604	arg1	beads					627:631	P. lilacinus-SN-Cal-Alg beads	603:631	P. lilacinus-SN-Cal-Alg beads	603:631	The adsorption capacity of Pb(II) by P. lilacinus-SN-Cal-Alg beads was analyzed in aqueous solution.
31492360	4	46	theme	lilacinus-Cal-Alg	769:785	arg1	beads					787:791	lilacinus-Cal-Alg beads	769:791	lilacinus-Cal-Alg beads	769:791	For comparison, the adsorption capacity of Pb(II) by another type of microbial composites, namely, P. lilacinus-Cal-Alg beads, without addition of silica nanoparticles, was also studied in parallel.
31492360	0	47	theme	Ions	18:21	arg1	Removal					0:6	Removal	0:6	Removal of Pb(II) Ions from Aqueous Solutions by Spherical Nanocomposites	0:72	Removal of Pb(II) Ions from Aqueous Solutions by Spherical Nanocomposites Synthesized Through Immobilization of Paecilomyces lilacinus in Silica Nanoparticles Coated with Ca-Alginate.
31492360	0	48	theme	Silica	138:143	arg1	Nanoparticles					145:157	Silica Nanoparticles	138:157	Silica Nanoparticles Coated with Ca-Alginate	138:181	Removal of Pb(II) Ions from Aqueous Solutions by Spherical Nanocomposites Synthesized Through Immobilization of Paecilomyces lilacinus in Silica Nanoparticles Coated with Ca-Alginate.
31492360	0	49	from	Immobilization	94:107	arg1	Nanoparticles					145:157	Silica Nanoparticles	138:157	Silica Nanoparticles Coated with Ca-Alginate	138:181	Removal of Pb(II) Ions from Aqueous Solutions by Spherical Nanocomposites Synthesized Through Immobilization of Paecilomyces lilacinus in Silica Nanoparticles Coated with Ca-Alginate.
31492360	3	50	theme	adsorption	570:579	arg1	capacity					581:588	The adsorption capacity	566:588	The adsorption capacity of Pb(II) by P. lilacinus-SN-Cal-Alg beads	566:631	The adsorption capacity of Pb(II) by P. lilacinus-SN-Cal-Alg beads was analyzed in aqueous solution.
31492360	5	51	from	data	890:893	arg1	process					909:915	adsorption process	898:915	adsorption process	898:915	Lastly, the equilibrium data in adsorption process were examined by both Langmuir and Freundlich isotherm models to evaluate adsorption mechanism.
31492360	4	52	theme	composites	746:755	arg1	type					728:731	another type	720:731	another type of microbial composites, namely, P. lilacinus-Cal-Alg beads	720:791	For comparison, the adsorption capacity of Pb(II) by another type of microbial composites, namely, P. lilacinus-Cal-Alg beads, without addition of silica nanoparticles, was also studied in parallel.
31492360	2	53	theme	XPS	552:554	arg1	analyses					556:563	XPS analyses	552:563	XPS analyses	552:563	P. lilacinus-SN-Cal-Alg beads before and after the adsorption of Pb(II) were characterized by FT-IR, SEM-EDS, and XPS analyses.
31492360	1	54	theme	aqueous	420:426	arg1	solution					428:435	aqueous solution	420:435	aqueous solution	420:435	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	4	55	theme	microbial	736:744	arg1	composites					746:755	microbial composites	736:755	microbial composites	736:755	For comparison, the adsorption capacity of Pb(II) by another type of microbial composites, namely, P. lilacinus-Cal-Alg beads, without addition of silica nanoparticles, was also studied in parallel.
31492360	6	56	theme	Pb	1072:1073	arg1	efficiency					1058:1067	an excellent removal efficiency	1037:1067	an excellent removal efficiency of Pb(II) in aqueous solution (85.54%)	1037:1106	The results showed that an excellent removal efficiency of Pb(II) in aqueous solution (85.54%) was obtained at initial concentration of 200 mg/L by using the P. lilacinus-SN-Cal-Alg beads.
31492360	1	57	theme	novel	208:212	arg1	"					304:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads"	206:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg)	206:330	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	1	57	theme	novel	208:212	arg1	lilacinus-SN-Cal-Alg					310:329	P. lilacinus-SN-Cal-Alg	307:329	P. lilacinus-SN-Cal-Alg	307:329	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	6	58	theme	initial	1124:1130	arg1	concentration					1132:1144	initial concentration	1124:1144	initial concentration of 200 mg/L	1124:1156	The results showed that an excellent removal efficiency of Pb(II) in aqueous solution (85.54%) was obtained at initial concentration of 200 mg/L by using the P. lilacinus-SN-Cal-Alg beads.
31492360	8	59	theme	lilacinus-SN-Cal-Alg	1332:1351	arg1	beads					1353:1357	P. lilacinus-SN-Cal-Alg beads	1329:1357	P. lilacinus-SN-Cal-Alg beads	1329:1357	The adsorption process by P. lilacinus-SN-Cal-Alg beads was best described by the Langmuir model indicating that monolayer adsorption of Pb(II) ions takes place on the beads surfaces and showed that its maximum adsorption capacity was 282.49 mg/g.
31492360	4	60	theme	adsorption	687:696	arg1	capacity					698:705	the adsorption capacity	683:705	the adsorption capacity of Pb	683:711	For comparison, the adsorption capacity of Pb(II) by another type of microbial composites, namely, P. lilacinus-Cal-Alg beads, without addition of silica nanoparticles, was also studied in parallel.
31492360	1	61	theme	microbial	214:222	arg1	"					304:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads"	206:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg)	206:330	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	1	61	theme	microbial	214:222	arg1	lilacinus-SN-Cal-Alg					310:329	P. lilacinus-SN-Cal-Alg	307:329	P. lilacinus-SN-Cal-Alg	307:329	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	3	62	theme	Pb	593:594	arg1	capacity					581:588	The adsorption capacity	566:588	The adsorption capacity of Pb(II) by P. lilacinus-SN-Cal-Alg beads	566:631	The adsorption capacity of Pb(II) by P. lilacinus-SN-Cal-Alg beads was analyzed in aqueous solution.
31492360	8	63	theme	adsorption	1307:1316	arg1	process					1318:1324	The adsorption process	1303:1324	The adsorption process by P. lilacinus-SN-Cal-Alg beads	1303:1357	The adsorption process by P. lilacinus-SN-Cal-Alg beads was best described by the Langmuir model indicating that monolayer adsorption of Pb(II) ions takes place on the beads surfaces and showed that its maximum adsorption capacity was 282.49 mg/g.
31492360	1	64	theme	nanocomposite	224:236	arg1	"					304:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads"	206:304	a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg)	206:330	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	1	64	theme	nanocomposite	224:236	arg1	lilacinus-SN-Cal-Alg					310:329	P. lilacinus-SN-Cal-Alg	307:329	P. lilacinus-SN-Cal-Alg	307:329	In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution.
31492360	0	65	theme	Aqueous	28:34	arg1	Solutions					36:44	Aqueous Solutions	28:44	Aqueous Solutions	28:44	Removal of Pb(II) Ions from Aqueous Solutions by Spherical Nanocomposites Synthesized Through Immobilization of Paecilomyces lilacinus in Silica Nanoparticles Coated with Ca-Alginate.
31492360	8	66	theme	monolayer	1416:1424	arg1	adsorption					1426:1435	monolayer adsorption	1416:1435	monolayer adsorption of Pb(II) ions	1416:1450	The adsorption process by P. lilacinus-SN-Cal-Alg beads was best described by the Langmuir model indicating that monolayer adsorption of Pb(II) ions takes place on the beads surfaces and showed that its maximum adsorption capacity was 282.49 mg/g.
31492360	2	67	theme	P.	438:439	arg1	beads					462:466	P. lilacinus-SN-Cal-Alg beads	438:466	P. lilacinus-SN-Cal-Alg beads before and after the adsorption of Pb(II)	438:508	P. lilacinus-SN-Cal-Alg beads before and after the adsorption of Pb(II) were characterized by FT-IR, SEM-EDS, and XPS analyses.
31492360	6	68	from	efficiency	1058:1067	arg1	solution					1090:1097	aqueous solution	1082:1097	aqueous solution (85.54%)	1082:1106	The results showed that an excellent removal efficiency of Pb(II) in aqueous solution (85.54%) was obtained at initial concentration of 200 mg/L by using the P. lilacinus-SN-Cal-Alg beads.
31492360	6	68	from	efficiency	1058:1067	arg1	%					1105:1105	85.54%	1100:1105	85.54%	1100:1105	The results showed that an excellent removal efficiency of Pb(II) in aqueous solution (85.54%) was obtained at initial concentration of 200 mg/L by using the P. lilacinus-SN-Cal-Alg beads.
31492360	6	69	theme	removal	1050:1056	arg1	efficiency					1058:1067	an excellent removal efficiency	1037:1067	an excellent removal efficiency of Pb(II) in aqueous solution (85.54%)	1037:1106	The results showed that an excellent removal efficiency of Pb(II) in aqueous solution (85.54%) was obtained at initial concentration of 200 mg/L by using the P. lilacinus-SN-Cal-Alg beads.
32176229	3	0	from	impact	454:459	arg1	effects					508:514	potential chemopreventive effects	482:514	potential chemopreventive effects	482:514	In order to address the impact of heat treatment on potential chemopreventive effects, barley flakes were roasted (160 °C-180 °C, approx.
32176229	9	1	theme	cells	1292:1296	arg1	activity					1272:1279	caspase-3 activity	1262:1279	caspase-3 activity of treated cells	1262:1296	The growth of LT97 cells was significantly reduced by barley FS in a time- and dose-dependent manner, and caspase-3 activity of treated cells was significantly enhanced (up to 6.3-fold, on average).
32176229	8	2	theme	ammonia	1051:1057	arg1	levels					1059:1064	ammonia levels	1051:1064	ammonia levels	1051:1064	Concentrations of SCFA were increased in barley FS (2.5-fold, on average) with a shift of molar ratios towards butyrate production, while ammonia levels were significantly decreased (0.7-fold, on average) compared to the fermentation control.
32176229	10	3	theme	CAT	1423:1425	arg1	levels					1413:1418	increased mRNA levels	1398:1418	increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold)	1398:1474	On average, treatment of cells resulted in increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold), while expression of GPx1 (0.3-fold) was significantly decreased in some cases.
32176229	7	4	theme	growth	785:790	arg1	expression					835:844	gene expression	830:844	gene expression of detoxifying enzymes	830:867	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	7	4	theme	growth	785:790	arg1	apoptosis					804:812	apoptosis	804:812	apoptosis	804:812	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	7	4	theme	growth	785:790	arg1	integrity					819:827	DNA integrity	815:827	DNA integrity	815:827	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	7	4	theme	growth	785:790	arg1	inhibition					792:801	growth inhibition	785:801	growth inhibition	785:801	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	9	5	theme	treated	1284:1290	arg1	cells					1292:1296	treated cells	1284:1296	treated cells	1284:1296	The growth of LT97 cells was significantly reduced by barley FS in a time- and dose-dependent manner, and caspase-3 activity of treated cells was significantly enhanced (up to 6.3-fold, on average).
32176229	6	6	theme	fatty	726:730	arg1	SCFA					739:742	SCFA	739:742	SCFA	739:742	Fermentation supernatants (FS) were analysed for the concentrations of short-chain fatty acids (SCFA) and ammonia.
32176229	6	6	theme	fatty	726:730	arg1	acids					732:736	short-chain fatty acids	714:736	short-chain fatty acids (SCFA)	714:743	Fermentation supernatants (FS) were analysed for the concentrations of short-chain fatty acids (SCFA) and ammonia.
32176229	3	7	theme	potential	482:490	arg1	effects					508:514	potential chemopreventive effects	482:514	potential chemopreventive effects	482:514	In order to address the impact of heat treatment on potential chemopreventive effects, barley flakes were roasted (160 °C-180 °C, approx.
32176229	1	8	theme	dietary	152:158	arg1	composition					166:176	their unique dietary fibre composition	139:176	their unique dietary fibre composition	139:176	Due to their unique dietary fibre composition, in particular β-glucan, the consumption of barley may contribute to a healthy diet and the prevention of colon cancer.
32176229	8	9	theme	fermentation	1134:1145	arg1	control					1147:1153	the fermentation control	1130:1153	the fermentation control	1130:1153	Concentrations of SCFA were increased in barley FS (2.5-fold, on average) with a shift of molar ratios towards butyrate production, while ammonia levels were significantly decreased (0.7-fold, on average) compared to the fermentation control.
32176229	12	10	theme	inhibitory	1789:1798	arg1	effects					1814:1820	growth inhibitory and apoptotic effects	1782:1820	growth inhibitory and apoptotic effects	1782:1820	Our results indicate chemopreventive potential of in vitro fermented waxy winter barley, mediated primarily by growth inhibitory and apoptotic effects, which is largely unaffected by roasting.
32176229	8	11	theme	SCFA	931:934	arg1	Concentrations					913:926	Concentrations	913:926	Concentrations of SCFA	913:934	Concentrations of SCFA were increased in barley FS (2.5-fold, on average) with a shift of molar ratios towards butyrate production, while ammonia levels were significantly decreased (0.7-fold, on average) compared to the fermentation control.
32176229	0	12	theme	human	103:107	arg1	model					125:129	an in vitro human colon digestion model	91:129	an in vitro human colon digestion model	91:129	Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model.
32176229	3	13	theme	barley	517:522	arg1	flakes					524:529	barley flakes	517:529	barley flakes	517:529	In order to address the impact of heat treatment on potential chemopreventive effects, barley flakes were roasted (160 °C-180 °C, approx.
32176229	12	14	theme	barley	1752:1757	arg1	potential					1708:1716	chemopreventive potential	1692:1716	chemopreventive potential	1692:1716	Our results indicate chemopreventive potential of in vitro fermented waxy winter barley, mediated primarily by growth inhibitory and apoptotic effects, which is largely unaffected by roasting.
32176229	0	15	theme	digestion	115:123	arg1	model					125:129	an in vitro human colon digestion model	91:129	an in vitro human colon digestion model	91:129	Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model.
32176229	3	16	theme	°C-180	549:554	arg1	°C					556:557	roasted (160 °C-180 °C	536:557	roasted (160 °C-180 °C	536:557	In order to address the impact of heat treatment on potential chemopreventive effects, barley flakes were roasted (160 °C-180 °C, approx.
32176229	12	17	theme	apoptotic	1804:1812	arg1	effects					1814:1820	growth inhibitory and apoptotic effects	1782:1820	growth inhibitory and apoptotic effects	1782:1820	Our results indicate chemopreventive potential of in vitro fermented waxy winter barley, mediated primarily by growth inhibitory and apoptotic effects, which is largely unaffected by roasting.
32176229	12	18	dep	in	1721:1722	arg1	vitro					1724:1728	vitro	1724:1728	vitro	1724:1728	Our results indicate chemopreventive potential of in vitro fermented waxy winter barley, mediated primarily by growth inhibitory and apoptotic effects, which is largely unaffected by roasting.
32176229	11	19	theme	barley	1612:1617	arg1	FS					1619:1620	barley FS	1612:1620	barley FS	1612:1620	The roasting process did not cause genotoxic effects of barley FS and had no impact on chemopreventive properties.
32176229	5	20	theme	in	606:607	arg1	digestion					615:623	in vitro digestion	606:623	in vitro digestion	606:623	The flakes were subjected to in vitro digestion and fermentation.
32176229	0	21	theme	β-glucan-rich	52:64	arg1	barley					78:83	roasted β-glucan-rich waxy winter barley	44:83	roasted β-glucan-rich waxy winter barley	44:83	Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model.
32176229	1	22	theme	cancer	290:295	arg1	diet					257:260	a healthy diet	247:260	a healthy diet	247:260	Due to their unique dietary fibre composition, in particular β-glucan, the consumption of barley may contribute to a healthy diet and the prevention of colon cancer.
32176229	1	22	theme	cancer	290:295	arg1	prevention					270:279	the prevention	266:279	the prevention of colon cancer	266:295	Due to their unique dietary fibre composition, in particular β-glucan, the consumption of barley may contribute to a healthy diet and the prevention of colon cancer.
32176229	7	23	theme	colon	892:896	arg1	cells					906:910	LT97 colon adenoma cells	887:910	LT97 colon adenoma cells	887:910	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	0	24	theme	winter	71:76	arg1	barley					78:83	roasted β-glucan-rich waxy winter barley	44:83	roasted β-glucan-rich waxy winter barley	44:83	Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model.
32176229	9	25	theme	cells	1175:1179	arg1	growth					1160:1165	The growth	1156:1165	The growth of LT97 cells	1156:1179	The growth of LT97 cells was significantly reduced by barley FS in a time- and dose-dependent manner, and caspase-3 activity of treated cells was significantly enhanced (up to 6.3-fold, on average).
32176229	12	26	theme	in	1721:1722	arg1	barley					1752:1757	in vitro fermented waxy winter barley	1721:1757	in vitro fermented waxy winter barley	1721:1757	Our results indicate chemopreventive potential of in vitro fermented waxy winter barley, mediated primarily by growth inhibitory and apoptotic effects, which is largely unaffected by roasting.
32176229	0	27	from	Study	0:4	arg1	effects					25:31	chemopreventive effects	9:31	chemopreventive effects of raw	9:38	Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model.
32176229	11	28	theme	roasting	1560:1567	arg1	process					1569:1575	The roasting process	1556:1575	The roasting process	1556:1575	The roasting process did not cause genotoxic effects of barley FS and had no impact on chemopreventive properties.
32176229	8	29	theme	barley	954:959	arg1	FS					961:962	barley FS	954:962	barley FS (2.5-fold, on average)	954:985	Concentrations of SCFA were increased in barley FS (2.5-fold, on average) with a shift of molar ratios towards butyrate production, while ammonia levels were significantly decreased (0.7-fold, on average) compared to the fermentation control.
32176229	0	30	dep	in	94:95	arg1	vitro					97:101	vitro	97:101	vitro	97:101	Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model.
32176229	2	31	theme	chemopreventive	342:356	arg1	effects					358:364	chemopreventive effects	342:364	chemopreventive effects of barley flakes obtained from a β-glucan-rich barley cultivar	342:427	The aim of the present study was to analyse chemopreventive effects of barley flakes obtained from a β-glucan-rich barley cultivar.
32176229	0	32	theme	in	94:95	arg1	model					125:129	an in vitro human colon digestion model	91:129	an in vitro human colon digestion model	91:129	Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model.
32176229	7	33	theme	enzymes	861:867	arg1	inhibition					792:801	growth inhibition	785:801	growth inhibition	785:801	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	7	33	theme	enzymes	861:867	arg1	expression					835:844	gene expression	830:844	gene expression of detoxifying enzymes	830:867	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	2	34	theme	β-glucan-rich	399:411	arg1	cultivar					420:427	a β-glucan-rich barley cultivar	397:427	a β-glucan-rich barley cultivar	397:427	The aim of the present study was to analyse chemopreventive effects of barley flakes obtained from a β-glucan-rich barley cultivar.
32176229	2	35	theme	present	313:319	arg1	study					321:325	the present study	309:325	the present study	309:325	The aim of the present study was to analyse chemopreventive effects of barley flakes obtained from a β-glucan-rich barley cultivar.
32176229	2	36	theme	flakes	376:381	arg1	effects					358:364	chemopreventive effects	342:364	chemopreventive effects of barley flakes obtained from a β-glucan-rich barley cultivar	342:427	The aim of the present study was to analyse chemopreventive effects of barley flakes obtained from a β-glucan-rich barley cultivar.
32176229	0	37	theme	chemopreventive	9:23	arg1	effects					25:31	chemopreventive effects	9:31	chemopreventive effects of raw	9:38	Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model.
32176229	10	38	theme	cells	1380:1384	arg1	treatment					1367:1375	treatment	1367:1375	treatment of cells	1367:1384	On average, treatment of cells resulted in increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold), while expression of GPx1 (0.3-fold) was significantly decreased in some cases.
32176229	9	39	dep	enhanced	1316:1323	arg1	6.3-fold					1332:1339	6.3-fold	1332:1339	6.3-fold	1332:1339	The growth of LT97 cells was significantly reduced by barley FS in a time- and dose-dependent manner, and caspase-3 activity of treated cells was significantly enhanced (up to 6.3-fold, on average).
32176229	11	40	contain	had	1626:1628	arg1	process					1569:1575	The roasting process	1556:1575	The roasting process	1556:1575	The roasting process did not cause genotoxic effects of barley FS and had no impact on chemopreventive properties.
32176229	11	40	contain	had	1626:1628	arg2	impact					1633:1638	no impact	1630:1638	no impact	1630:1638	The roasting process did not cause genotoxic effects of barley FS and had no impact on chemopreventive properties.
32176229	8	41	dep	decreased	1085:1093	arg1	0.7-fold					1096:1103	0.7-fold	1096:1103	0.7-fold	1096:1103	Concentrations of SCFA were increased in barley FS (2.5-fold, on average) with a shift of molar ratios towards butyrate production, while ammonia levels were significantly decreased (0.7-fold, on average) compared to the fermentation control.
32176229	8	42	theme	molar	1003:1007	arg1	ratios					1009:1014	molar ratios	1003:1014	molar ratios	1003:1014	Concentrations of SCFA were increased in barley FS (2.5-fold, on average) with a shift of molar ratios towards butyrate production, while ammonia levels were significantly decreased (0.7-fold, on average) compared to the fermentation control.
32176229	6	43	theme	ammonia	749:755	arg1	concentrations					696:709	the concentrations	692:709	the concentrations of short-chain fatty acids (SCFA) and ammonia	692:755	Fermentation supernatants (FS) were analysed for the concentrations of short-chain fatty acids (SCFA) and ammonia.
32176229	10	44	theme	mRNA	1408:1411	arg1	levels					1413:1418	increased mRNA levels	1398:1418	increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold)	1398:1474	On average, treatment of cells resulted in increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold), while expression of GPx1 (0.3-fold) was significantly decreased in some cases.
32176229	9	45	dep	6.3-fold	1332:1339	arg1	up					1326:1327	up	1326:1327	up	1326:1327	The growth of LT97 cells was significantly reduced by barley FS in a time- and dose-dependent manner, and caspase-3 activity of treated cells was significantly enhanced (up to 6.3-fold, on average).
32176229	3	46	theme	heat	464:467	arg1	treatment					469:477	heat treatment	464:477	heat treatment	464:477	In order to address the impact of heat treatment on potential chemopreventive effects, barley flakes were roasted (160 °C-180 °C, approx.
32176229	8	47	from	0.7-fold	1096:1103	arg1	average					1109:1115	average	1109:1115	average	1109:1115	Concentrations of SCFA were increased in barley FS (2.5-fold, on average) with a shift of molar ratios towards butyrate production, while ammonia levels were significantly decreased (0.7-fold, on average) compared to the fermentation control.
32176229	7	48	theme	DNA	815:817	arg1	integrity					819:827	DNA integrity	815:827	DNA integrity	815:827	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	7	48	theme	DNA	815:817	arg1	inhibition					792:801	growth inhibition	785:801	growth inhibition	785:801	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	1	49	theme	barley	222:227	arg1	consumption					207:217	the consumption	203:217	the consumption of barley	203:227	Due to their unique dietary fibre composition, in particular β-glucan, the consumption of barley may contribute to a healthy diet and the prevention of colon cancer.
32176229	8	50	dep	FS	961:962	arg1	2.5-fold					965:972	2.5-fold	965:972	2.5-fold	965:972	Concentrations of SCFA were increased in barley FS (2.5-fold, on average) with a shift of molar ratios towards butyrate production, while ammonia levels were significantly decreased (0.7-fold, on average) compared to the fermentation control.
32176229	3	51	theme	chemopreventive	492:506	arg1	effects					508:514	potential chemopreventive effects	482:514	potential chemopreventive effects	482:514	In order to address the impact of heat treatment on potential chemopreventive effects, barley flakes were roasted (160 °C-180 °C, approx.
32176229	6	52	theme	acids	732:736	arg1	concentrations					696:709	the concentrations	692:709	the concentrations of short-chain fatty acids (SCFA) and ammonia	692:755	Fermentation supernatants (FS) were analysed for the concentrations of short-chain fatty acids (SCFA) and ammonia.
32176229	1	53	theme	unique	145:150	arg1	composition					166:176	their unique dietary fibre composition	139:176	their unique dietary fibre composition	139:176	Due to their unique dietary fibre composition, in particular β-glucan, the consumption of barley may contribute to a healthy diet and the prevention of colon cancer.
32176229	10	54	theme	SOD2	1439:1442	arg1	levels					1413:1418	increased mRNA levels	1398:1418	increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold)	1398:1474	On average, treatment of cells resulted in increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold), while expression of GPx1 (0.3-fold) was significantly decreased in some cases.
32176229	6	55	theme	short-chain	714:724	arg1	SCFA					739:742	SCFA	739:742	SCFA	739:742	Fermentation supernatants (FS) were analysed for the concentrations of short-chain fatty acids (SCFA) and ammonia.
32176229	6	55	theme	short-chain	714:724	arg1	acids					732:736	short-chain fatty acids	714:736	short-chain fatty acids (SCFA)	714:743	Fermentation supernatants (FS) were analysed for the concentrations of short-chain fatty acids (SCFA) and ammonia.
32176229	1	56	theme	fibre	160:164	arg1	composition					166:176	their unique dietary fibre composition	139:176	their unique dietary fibre composition	139:176	Due to their unique dietary fibre composition, in particular β-glucan, the consumption of barley may contribute to a healthy diet and the prevention of colon cancer.
32176229	0	57	theme	colon	109:113	arg1	model					125:129	an in vitro human colon digestion model	91:129	an in vitro human colon digestion model	91:129	Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model.
32176229	7	58	theme	Chemopreventive	758:772	arg1	endpoints					774:782	Chemopreventive endpoints	758:782	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes)	758:868	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	2	59	theme	study	321:325	arg1	aim					302:304	The aim	298:304	The aim of the present study	298:325	The aim of the present study was to analyse chemopreventive effects of barley flakes obtained from a β-glucan-rich barley cultivar.
32176229	0	60	from	barley	78:83	arg1	effects					25:31	chemopreventive effects	9:31	chemopreventive effects of raw	9:38	Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model.
32176229	11	61	theme	genotoxic	1591:1599	arg1	effects					1601:1607	genotoxic effects	1591:1607	genotoxic effects of barley FS	1591:1620	The roasting process did not cause genotoxic effects of barley FS and had no impact on chemopreventive properties.
32176229	1	62	theme	particular	182:191	arg1	β-glucan					193:200	particular β-glucan	182:200	particular β-glucan	182:200	Due to their unique dietary fibre composition, in particular β-glucan, the consumption of barley may contribute to a healthy diet and the prevention of colon cancer.
32176229	12	63	theme	winter	1745:1750	arg1	barley					1752:1757	in vitro fermented waxy winter barley	1721:1757	in vitro fermented waxy winter barley	1721:1757	Our results indicate chemopreventive potential of in vitro fermented waxy winter barley, mediated primarily by growth inhibitory and apoptotic effects, which is largely unaffected by roasting.
32176229	3	64	theme	roasted	536:542	arg1	°C					556:557	roasted (160 °C-180 °C	536:557	roasted (160 °C-180 °C	536:557	In order to address the impact of heat treatment on potential chemopreventive effects, barley flakes were roasted (160 °C-180 °C, approx.
32176229	11	65	theme	FS	1619:1620	arg1	effects					1601:1607	genotoxic effects	1591:1607	genotoxic effects of barley FS	1591:1620	The roasting process did not cause genotoxic effects of barley FS and had no impact on chemopreventive properties.
32176229	0	66	theme	waxy	66:69	arg1	barley					78:83	roasted β-glucan-rich waxy winter barley	44:83	roasted β-glucan-rich waxy winter barley	44:83	Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model.
32176229	9	67	theme	LT97	1170:1173	arg1	cells					1175:1179	LT97 cells	1170:1179	LT97 cells	1170:1179	The growth of LT97 cells was significantly reduced by barley FS in a time- and dose-dependent manner, and caspase-3 activity of treated cells was significantly enhanced (up to 6.3-fold, on average).
32176229	7	68	theme	adenoma	898:904	arg1	cells					906:910	LT97 colon adenoma cells	887:910	LT97 colon adenoma cells	887:910	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	12	69	theme	fermented	1730:1738	arg1	barley					1752:1757	in vitro fermented waxy winter barley	1721:1757	in vitro fermented waxy winter barley	1721:1757	Our results indicate chemopreventive potential of in vitro fermented waxy winter barley, mediated primarily by growth inhibitory and apoptotic effects, which is largely unaffected by roasting.
32176229	12	70	theme	waxy	1740:1743	arg1	barley					1752:1757	in vitro fermented waxy winter barley	1721:1757	in vitro fermented waxy winter barley	1721:1757	Our results indicate chemopreventive potential of in vitro fermented waxy winter barley, mediated primarily by growth inhibitory and apoptotic effects, which is largely unaffected by roasting.
32176229	7	71	theme	LT97	887:890	arg1	cells					906:910	LT97 colon adenoma cells	887:910	LT97 colon adenoma cells	887:910	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	6	72	theme	Fermentation	643:654	arg1	FS					670:671	FS	670:671	FS	670:671	Fermentation supernatants (FS) were analysed for the concentrations of short-chain fatty acids (SCFA) and ammonia.
32176229	6	72	theme	Fermentation	643:654	arg1	supernatants					656:667	Fermentation supernatants	643:667	Fermentation supernatants (FS)	643:672	Fermentation supernatants (FS) were analysed for the concentrations of short-chain fatty acids (SCFA) and ammonia.
32176229	12	73	theme	chemopreventive	1692:1706	arg1	potential					1708:1716	chemopreventive potential	1692:1716	chemopreventive potential	1692:1716	Our results indicate chemopreventive potential of in vitro fermented waxy winter barley, mediated primarily by growth inhibitory and apoptotic effects, which is largely unaffected by roasting.
32176229	5	74	dep	in	606:607	arg1	vitro					609:613	vitro	609:613	vitro	609:613	The flakes were subjected to in vitro digestion and fermentation.
32176229	9	75	theme	barley	1210:1215	arg1	FS					1217:1218	barley FS	1210:1218	barley FS	1210:1218	The growth of LT97 cells was significantly reduced by barley FS in a time- and dose-dependent manner, and caspase-3 activity of treated cells was significantly enhanced (up to 6.3-fold, on average).
32176229	10	76	dep	GPx1	1497:1500	arg1	0.3-fold					1503:1510	0.3-fold	1503:1510	0.3-fold	1503:1510	On average, treatment of cells resulted in increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold), while expression of GPx1 (0.3-fold) was significantly decreased in some cases.
32176229	10	77	theme	GSTP1	1459:1463	arg1	levels					1413:1418	increased mRNA levels	1398:1418	increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold)	1398:1474	On average, treatment of cells resulted in increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold), while expression of GPx1 (0.3-fold) was significantly decreased in some cases.
32176229	1	78	theme	healthy	249:255	arg1	diet					257:260	a healthy diet	247:260	a healthy diet	247:260	Due to their unique dietary fibre composition, in particular β-glucan, the consumption of barley may contribute to a healthy diet and the prevention of colon cancer.
32176229	7	79	theme	detoxifying	849:859	arg1	enzymes					861:867	detoxifying enzymes	849:867	detoxifying enzymes	849:867	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	2	80	theme	barley	369:374	arg1	flakes					376:381	barley flakes	369:381	barley flakes obtained from a β-glucan-rich barley cultivar	369:427	The aim of the present study was to analyse chemopreventive effects of barley flakes obtained from a β-glucan-rich barley cultivar.
32176229	0	81	theme	raw	36:38	arg1	effects					25:31	chemopreventive effects	9:31	chemopreventive effects of raw	9:38	Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model.
32176229	9	82	theme	time-	1225:1229	arg1	manner					1250:1255	a time- and dose-dependent manner	1223:1255	a time- and dose-dependent manner	1223:1255	The growth of LT97 cells was significantly reduced by barley FS in a time- and dose-dependent manner, and caspase-3 activity of treated cells was significantly enhanced (up to 6.3-fold, on average).
32176229	7	83	dep	endpoints	774:782	arg1	expression					835:844	gene expression	830:844	gene expression of detoxifying enzymes	830:867	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	7	83	dep	endpoints	774:782	arg1	apoptosis					804:812	apoptosis	804:812	apoptosis	804:812	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	7	83	dep	endpoints	774:782	arg1	integrity					819:827	DNA integrity	815:827	DNA integrity	815:827	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	7	83	dep	endpoints	774:782	arg1	inhibition					792:801	growth inhibition	785:801	growth inhibition	785:801	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	0	84	theme	roasted	44:50	arg1	barley					78:83	roasted β-glucan-rich waxy winter barley	44:83	roasted β-glucan-rich waxy winter barley	44:83	Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model.
32176229	9	85	theme	dose-dependent	1235:1248	arg1	manner					1250:1255	a time- and dose-dependent manner	1223:1255	a time- and dose-dependent manner	1223:1255	The growth of LT97 cells was significantly reduced by barley FS in a time- and dose-dependent manner, and caspase-3 activity of treated cells was significantly enhanced (up to 6.3-fold, on average).
32176229	2	86	theme	barley	413:418	arg1	cultivar					420:427	a β-glucan-rich barley cultivar	397:427	a β-glucan-rich barley cultivar	397:427	The aim of the present study was to analyse chemopreventive effects of barley flakes obtained from a β-glucan-rich barley cultivar.
32176229	11	87	theme	chemopreventive	1643:1657	arg1	properties					1659:1668	chemopreventive properties	1643:1668	chemopreventive properties	1643:1668	The roasting process did not cause genotoxic effects of barley FS and had no impact on chemopreventive properties.
32176229	7	88	theme	gene	830:833	arg1	inhibition					792:801	growth inhibition	785:801	growth inhibition	785:801	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	7	88	theme	gene	830:833	arg1	expression					835:844	gene expression	830:844	gene expression of detoxifying enzymes	830:867	Chemopreventive endpoints (growth inhibition, apoptosis, DNA integrity, gene expression of detoxifying enzymes) were analysed in LT97 colon adenoma cells.
32176229	1	89	theme	colon	284:288	arg1	cancer					290:295	colon cancer	284:295	colon cancer	284:295	Due to their unique dietary fibre composition, in particular β-glucan, the consumption of barley may contribute to a healthy diet and the prevention of colon cancer.
32176229	8	90	theme	ratios	1009:1014	arg1	shift					994:998	a shift	992:998	a shift of molar ratios towards butyrate production	992:1042	Concentrations of SCFA were increased in barley FS (2.5-fold, on average) with a shift of molar ratios towards butyrate production, while ammonia levels were significantly decreased (0.7-fold, on average) compared to the fermentation control.
32176229	10	91	dep	GSTP1	1459:1463	arg1	3.9-fold					1466:1473	3.9-fold	1466:1473	3.9-fold	1466:1473	On average, treatment of cells resulted in increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold), while expression of GPx1 (0.3-fold) was significantly decreased in some cases.
32176229	10	92	theme	GPx1	1497:1500	arg1	expression					1483:1492	expression	1483:1492	expression of GPx1 (0.3-fold)	1483:1511	On average, treatment of cells resulted in increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold), while expression of GPx1 (0.3-fold) was significantly decreased in some cases.
32176229	9	93	theme	caspase-3	1262:1270	arg1	activity					1272:1279	caspase-3 activity	1262:1279	caspase-3 activity of treated cells	1262:1296	The growth of LT97 cells was significantly reduced by barley FS in a time- and dose-dependent manner, and caspase-3 activity of treated cells was significantly enhanced (up to 6.3-fold, on average).
32176229	8	94	theme	butyrate	1024:1031	arg1	production					1033:1042	butyrate production	1024:1042	butyrate production	1024:1042	Concentrations of SCFA were increased in barley FS (2.5-fold, on average) with a shift of molar ratios towards butyrate production, while ammonia levels were significantly decreased (0.7-fold, on average) compared to the fermentation control.
32176229	10	95	theme	increased	1398:1406	arg1	levels					1413:1418	increased mRNA levels	1398:1418	increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold)	1398:1474	On average, treatment of cells resulted in increased mRNA levels of CAT (2.1-fold), SOD2 (2.2-fold) and GSTP1 (3.9-fold), while expression of GPx1 (0.3-fold) was significantly decreased in some cases.
32176229	3	96	theme	treatment	469:477	arg1	impact					454:459	the impact	450:459	the impact of heat treatment on potential chemopreventive effects	450:514	In order to address the impact of heat treatment on potential chemopreventive effects, barley flakes were roasted (160 °C-180 °C, approx.
33460901	0	0	from	studies	17:23	arg1	chitosan/orange					45:59	surface tailored chitosan/orange	28:59	surface tailored chitosan/orange	28:59	Batch adsorption studies on surface tailored chitosan/orange peel hydrogel composite for the removal of Cr(VI) and Cu(II) ions from synthetic wastewater.
33460901	0	1	theme	synthetic	132:140	arg1	wastewater					142:151	synthetic wastewater	132:151	synthetic wastewater	132:151	Batch adsorption studies on surface tailored chitosan/orange peel hydrogel composite for the removal of Cr(VI) and Cu(II) ions from synthetic wastewater.
33460901	7	2	theme	initial	1291:1297	arg1	4					1232:1232	4	1232:1232	4	1232:1232	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	7	2	theme	initial	1291:1297	arg1	concentration					1309:1321	initial metal ion concentration	1291:1321	initial metal ion concentration	1291:1321	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	6	3	theme	different	1027:1035	arg1	concentrations					1086:1099	different metal ion concentrations	1066:1099	different metal ion concentrations	1066:1099	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	6	3	theme	different	1027:1035	arg1	dosages					1057:1063	different time, pH, adsorbent dosages	1027:1063	dosages	1057:1063	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	7	4	theme	metal	1299:1303	arg1	4					1232:1232	4	1232:1232	4	1232:1232	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	7	4	theme	metal	1299:1303	arg1	concentration					1309:1321	initial metal ion concentration	1291:1321	initial metal ion concentration	1291:1321	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	7	5	theme	adsorbent	1264:1272	arg1	4					1232:1232	4	1232:1232	4	1232:1232	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	7	5	theme	adsorbent	1264:1272	arg1	4 g					1282:1284	adsorbent dosage: 4 g	1264:1284	adsorbent dosage: 4 g	1264:1284	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	6	6	theme	time	1037:1040	arg1	concentrations					1086:1099	different metal ion concentrations	1066:1099	different metal ion concentrations	1066:1099	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	6	6	theme	time	1037:1040	arg1	dosages					1057:1063	different time, pH, adsorbent dosages	1027:1063	dosages	1057:1063	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	2	7	theme	effective	300:308	arg1	adsorbents					310:319	very effective adsorbents	295:319	very effective adsorbents	295:319	Various materials act as very effective adsorbents to remove heavy metals, which cause toxicity to plants and all other living organisms.
33460901	1	8	theme	significant	209:219	arg1	process					221:227	a significant process	207:227	a significant process to improve the aquatic source's quality	207:267	Elimination of heavy metals from wastewater has been a significant process to improve the aquatic source's quality.
33460901	1	8	theme	significant	209:219	arg1	Elimination					154:164	Elimination	154:164	Elimination of heavy metals from wastewater	154:196	Elimination of heavy metals from wastewater has been a significant process to improve the aquatic source's quality.
33460901	4	9	theme	orange	739:744	arg1	peel					746:749	orange peel	739:749	orange peel	739:749	The composite was prepared via chemical cross-linking of radical chitosan with polyacrylamide and N,N'-Methylene bisacrylamide and blended with orange peel.
33460901	3	10	dep	metals	457:462	arg1	Cr					474:475	Cr	474:475	Cr	474:475	Thus, the present work focuses on removing heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite.
33460901	3	10	dep	metals	457:462	arg1	chromium					464:471	chromium	464:471	chromium (Cr)	464:476	Thus, the present work focuses on removing heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite.
33460901	3	10	dep	metals	457:462	arg1	ions					494:497	copper (Cu) ions	482:497	copper (Cu) ions	482:497	Thus, the present work focuses on removing heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite.
33460901	5	11	theme	Energy	891:896	arg1	analysis					915:922	Energy dispersive X-ray analysis	891:922	Energy dispersive X-ray analysis	891:922	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	6	12	theme	metal	1076:1080	arg1	concentrations					1086:1099	different metal ion concentrations	1066:1099	different metal ion concentrations	1066:1099	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	6	12	theme	metal	1076:1080	arg1	dosages					1057:1063	different time, pH, adsorbent dosages	1027:1063	dosages	1057:1063	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	6	13	theme	Absorption	1131:1140	arg1	AAS					1156:1158	AAS	1156:1158	AAS	1156:1158	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	6	13	theme	Absorption	1131:1140	arg1	Spectroscopy					1142:1153	Atomic Absorption Spectroscopy	1124:1153	Atomic Absorption Spectroscopy (AAS)	1124:1159	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	0	14	dep	Cr	104:105	arg1	VI					107:108	VI	107:108	VI	107:108	Batch adsorption studies on surface tailored chitosan/orange peel hydrogel composite for the removal of Cr(VI) and Cu(II) ions from synthetic wastewater.
33460901	3	15	contain	containing	499:508	arg2	wastewater					510:519	wastewater	510:519	wastewater using biodegradable and cost-effective chitosan-based hydrogel composite	510:592	Thus, the present work focuses on removing heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite.
33460901	3	15	contain	containing	499:508	arg1	metals					457:462	heavy metals chromium (Cr) and copper (Cu) ions	451:497	heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite	451:592	Thus, the present work focuses on removing heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite.
33460901	4	16	with	cross-linking	635:647	arg1	N					693:693	polyacrylamide and N	674:693	N	693:693	The composite was prepared via chemical cross-linking of radical chitosan with polyacrylamide and N,N'-Methylene bisacrylamide and blended with orange peel.
33460901	4	16	with	cross-linking	635:647	arg1	bisacrylamide					708:720	N'-Methylene bisacrylamide	695:720	N'-Methylene bisacrylamide	695:720	The composite was prepared via chemical cross-linking of radical chitosan with polyacrylamide and N,N'-Methylene bisacrylamide and blended with orange peel.
33460901	4	16	with	cross-linking	635:647	arg1	polyacrylamide					674:687	polyacrylamide and N	674:693	polyacrylamide	674:687	The composite was prepared via chemical cross-linking of radical chitosan with polyacrylamide and N,N'-Methylene bisacrylamide and blended with orange peel.
33460901	7	17	theme	dosage	1274:1279	arg1	4					1232:1232	4	1232:1232	4	1232:1232	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	7	17	theme	dosage	1274:1279	arg1	4 g					1282:1284	adsorbent dosage: 4 g	1264:1284	adsorbent dosage: 4 g	1264:1284	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	6	18	theme	ions	1019:1022	arg1	composite					1000:1008	the composite	996:1008	the composite of metal ions	996:1022	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	6	18	theme	ions	1019:1022	arg1	ions					1019:1022	metal ions	1013:1022	metal ions	1013:1022	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	0	19	theme	Cr	104:105	arg1	removal					93:99	the removal	89:99	the removal of Cr(VI) and Cu(II) ions from synthetic wastewater	89:151	Batch adsorption studies on surface tailored chitosan/orange peel hydrogel composite for the removal of Cr(VI) and Cu(II) ions from synthetic wastewater.
33460901	9	20	dep	Cr	1519:1520	arg1	VI					1522:1523	VI	1522:1523	VI	1522:1523	From the results, the adsorption capacity was observed to be 80.43% for Cr(VI) and 82.47% for Cu(II) ions, respectively.
33460901	8	21	theme	adsorption	1358:1367	arg1	models					1378:1383	The adsorption isotherm models	1354:1383	The adsorption isotherm models	1354:1383	The adsorption isotherm models follow the Freundlich model and pseudo-second-order kinetics.
33460901	0	22	theme	Batch	0:4	arg1	studies					17:23	Batch adsorption studies	0:23	Batch adsorption studies on surface tailored chitosan/orange	0:59	Batch adsorption studies on surface tailored chitosan/orange peel hydrogel composite for the removal of Cr(VI) and Cu(II) ions from synthetic wastewater.
33460901	5	23	theme	Fourier-transform	811:827	arg1	SEM-EDAX					925:932	SEM-EDAX	925:932	SEM-EDAX	925:932	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	5	23	theme	Fourier-transform	811:827	arg1	FT-IR					852:856	FT-IR	852:856	FT-IR	852:856	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	5	23	theme	Fourier-transform	811:827	arg1	spectroscopy					838:849	Fourier-transform infrared spectroscopy	811:849	Fourier-transform infrared spectroscopy (FT-IR)	811:857	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	0	24	theme	adsorption	6:15	arg1	studies					17:23	Batch adsorption studies	0:23	Batch adsorption studies on surface tailored chitosan/orange	0:59	Batch adsorption studies on surface tailored chitosan/orange peel hydrogel composite for the removal of Cr(VI) and Cu(II) ions from synthetic wastewater.
33460901	6	25	theme	ion	1082:1084	arg1	concentrations					1086:1099	different metal ion concentrations	1066:1099	different metal ion concentrations	1066:1099	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	6	25	theme	ion	1082:1084	arg1	dosages					1057:1063	different time, pH, adsorbent dosages	1027:1063	dosages	1057:1063	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	2	26	theme	Various	270:276	arg1	materials					278:286	Various materials	270:286	Various materials	270:286	Various materials act as very effective adsorbents to remove heavy metals, which cause toxicity to plants and all other living organisms.
33460901	7	27	theme	ion	1305:1307	arg1	4					1232:1232	4	1232:1232	4	1232:1232	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	7	27	theme	ion	1305:1307	arg1	concentration					1309:1321	initial metal ion concentration	1291:1321	initial metal ion concentration	1291:1321	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	5	28	theme	infrared	829:836	arg1	SEM-EDAX					925:932	SEM-EDAX	925:932	SEM-EDAX	925:932	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	5	28	theme	infrared	829:836	arg1	FT-IR					852:856	FT-IR	852:856	FT-IR	852:856	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	5	28	theme	infrared	829:836	arg1	spectroscopy					838:849	Fourier-transform infrared spectroscopy	811:849	Fourier-transform infrared spectroscopy (FT-IR)	811:857	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	2	29	theme	other	384:388	arg1	organisms					397:405	all other living organisms	380:405	all other living organisms	380:405	Various materials act as very effective adsorbents to remove heavy metals, which cause toxicity to plants and all other living organisms.
33460901	7	30	theme	metal	1342:1346	arg1	ions					1348:1351	each metal ions	1337:1351	each metal ions	1337:1351	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	3	31	theme	Cu	490:491	arg1	ions					494:497	copper (Cu) ions	482:497	copper (Cu) ions	482:497	Thus, the present work focuses on removing heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite.
33460901	2	32	theme	heavy	331:335	arg1	metals					337:342	heavy metals	331:342	heavy metals	331:342	Various materials act as very effective adsorbents to remove heavy metals, which cause toxicity to plants and all other living organisms.
33460901	0	33	from	wastewater	142:151	arg1	removal					93:99	the removal	89:99	the removal of Cr(VI) and Cu(II) ions from synthetic wastewater	89:151	Batch adsorption studies on surface tailored chitosan/orange peel hydrogel composite for the removal of Cr(VI) and Cu(II) ions from synthetic wastewater.
33460901	4	34	theme	N'-Methylene	695:706	arg1	bisacrylamide					708:720	N'-Methylene bisacrylamide	695:720	N'-Methylene bisacrylamide	695:720	The composite was prepared via chemical cross-linking of radical chitosan with polyacrylamide and N,N'-Methylene bisacrylamide and blended with orange peel.
33460901	4	34	theme	N'-Methylene	695:706	arg1	polyacrylamide					674:687	polyacrylamide and N	674:693	polyacrylamide	674:687	The composite was prepared via chemical cross-linking of radical chitosan with polyacrylamide and N,N'-Methylene bisacrylamide and blended with orange peel.
33460901	5	35	theme	dispersive	898:907	arg1	analysis					915:922	Energy dispersive X-ray analysis	891:922	Energy dispersive X-ray analysis	891:922	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	1	36	theme	aquatic	244:250	arg1	quality					261:267	the aquatic source's quality	240:267	the aquatic source's quality	240:267	Elimination of heavy metals from wastewater has been a significant process to improve the aquatic source's quality.
33460901	3	37	theme	copper	482:487	arg1	ions					494:497	copper (Cu) ions	482:497	copper (Cu) ions	482:497	Thus, the present work focuses on removing heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite.
33460901	4	38	theme	chemical	626:633	arg1	cross-linking					635:647	chemical cross-linking	626:647	chemical cross-linking of radical chitosan with polyacrylamide and N,N'-Methylene bisacrylamide	626:720	The composite was prepared via chemical cross-linking of radical chitosan with polyacrylamide and N,N'-Methylene bisacrylamide and blended with orange peel.
33460901	0	39	theme	tailored	36:43	arg1	chitosan/orange					45:59	surface tailored chitosan/orange	28:59	surface tailored chitosan/orange	28:59	Batch adsorption studies on surface tailored chitosan/orange peel hydrogel composite for the removal of Cr(VI) and Cu(II) ions from synthetic wastewater.
33460901	5	40	theme	electron	869:876	arg1	microscopy					878:887	Scanning electron microscopy	860:887	Scanning electron microscopy	860:887	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	0	41	theme	Cu	115:116	arg1	ions					122:125	Cu(II) ions	115:125	Cu(II) ions	115:125	Batch adsorption studies on surface tailored chitosan/orange peel hydrogel composite for the removal of Cr(VI) and Cu(II) ions from synthetic wastewater.
33460901	6	42	theme	adsorbent	1047:1055	arg1	concentrations					1086:1099	different metal ion concentrations	1066:1099	different metal ion concentrations	1066:1099	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	6	42	theme	adsorbent	1047:1055	arg1	dosages					1057:1063	different time, pH, adsorbent dosages	1027:1063	dosages	1057:1063	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	7	43	theme	contact	1241:1247	arg1	4					1232:1232	4	1232:1232	4	1232:1232	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	7	43	theme	contact	1241:1247	arg1	time					1249:1252	contact time	1241:1252	contact time	1241:1252	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	6	44	theme	composite	1000:1008	arg1	power					987:991	The adsorption power	972:991	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations	972:1099	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	1	45	theme	heavy	169:173	arg1	metals					175:180	heavy metals	169:180	heavy metals	169:180	Elimination of heavy metals from wastewater has been a significant process to improve the aquatic source's quality.
33460901	0	46	theme	surface	28:34	arg1	chitosan/orange					45:59	surface tailored chitosan/orange	28:59	surface tailored chitosan/orange	28:59	Batch adsorption studies on surface tailored chitosan/orange peel hydrogel composite for the removal of Cr(VI) and Cu(II) ions from synthetic wastewater.
33460901	8	47	theme	pseudo-second-order	1417:1435	arg1	kinetics					1437:1444	the Freundlich model and pseudo-second-order kinetics	1392:1444	kinetics	1437:1444	The adsorption isotherm models follow the Freundlich model and pseudo-second-order kinetics.
33460901	9	48	theme	adsorption	1469:1478	arg1	capacity					1480:1487	the adsorption capacity	1465:1487	the adsorption capacity	1465:1487	From the results, the adsorption capacity was observed to be 80.43% for Cr(VI) and 82.47% for Cu(II) ions, respectively.
33460901	9	48	theme	adsorption	1469:1478	arg1	%					1513:1513	80.43%	1508:1513	80.43% for Cr(VI)	1508:1524	From the results, the adsorption capacity was observed to be 80.43% for Cr(VI) and 82.47% for Cu(II) ions, respectively.
33460901	3	49	theme	chitosan-based	560:573	arg1	composite					584:592	biodegradable and cost-effective chitosan-based hydrogel composite	527:592	biodegradable and cost-effective chitosan-based hydrogel composite	527:592	Thus, the present work focuses on removing heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite.
33460901	5	50	dep	spectroscopy	838:849	arg1	studies					963:969	studies	963:969	studies	963:969	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	7	51	theme	optimum	1193:1199	arg1	4					1232:1232	4	1232:1232	4	1232:1232	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	7	51	theme	optimum	1193:1199	arg1	pH					1201:1202	the optimum pH	1189:1202	the optimum pH for Cr(VI) and Cu (II)	1189:1225	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	1	52	theme	metals	175:180	arg1	process					221:227	a significant process	207:227	a significant process to improve the aquatic source's quality	207:267	Elimination of heavy metals from wastewater has been a significant process to improve the aquatic source's quality.
33460901	1	52	theme	metals	175:180	arg1	Elimination					154:164	Elimination	154:164	Elimination of heavy metals from wastewater	154:196	Elimination of heavy metals from wastewater has been a significant process to improve the aquatic source's quality.
33460901	5	53	theme	adsorbent	773:781	arg1	synthesis					756:764	The synthesis	752:764	The synthesis of the adsorbent	752:781	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	3	54	theme	hydrogel	575:582	arg1	composite					584:592	biodegradable and cost-effective chitosan-based hydrogel composite	527:592	biodegradable and cost-effective chitosan-based hydrogel composite	527:592	Thus, the present work focuses on removing heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite.
33460901	9	55	theme	Cu	1541:1542	arg1	ions					1548:1551	Cu(II) ions	1541:1551	Cu(II) ions	1541:1551	From the results, the adsorption capacity was observed to be 80.43% for Cr(VI) and 82.47% for Cu(II) ions, respectively.
33460901	4	56	theme	chitosan	660:667	arg1	cross-linking					635:647	chemical cross-linking	626:647	chemical cross-linking of radical chitosan with polyacrylamide and N,N'-Methylene bisacrylamide	626:720	The composite was prepared via chemical cross-linking of radical chitosan with polyacrylamide and N,N'-Methylene bisacrylamide and blended with orange peel.
33460901	6	57	dep	dosages	1057:1063	arg1	pH					1043:1044	different time, pH, adsorbent dosages	1027:1063	pH	1043:1044	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	8	58	theme	Freundlich	1396:1405	arg1	model					1407:1411	the Freundlich model and pseudo-second-order kinetics	1392:1444	model	1407:1411	The adsorption isotherm models follow the Freundlich model and pseudo-second-order kinetics.
33460901	6	59	theme	different	1066:1074	arg1	concentrations					1086:1099	different metal ion concentrations	1066:1099	different metal ion concentrations	1066:1099	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	6	59	theme	different	1066:1074	arg1	dosages					1057:1063	different time, pH, adsorbent dosages	1027:1063	dosages	1057:1063	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	6	60	from	dosages	1057:1063	arg1	power					987:991	The adsorption power	972:991	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations	972:1099	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	4	61	theme	radical	652:658	arg1	chitosan					660:667	radical chitosan	652:667	radical chitosan	652:667	The composite was prepared via chemical cross-linking of radical chitosan with polyacrylamide and N,N'-Methylene bisacrylamide and blended with orange peel.
33460901	0	62	theme	ions	122:125	arg1	removal					93:99	the removal	89:99	the removal of Cr(VI) and Cu(II) ions from synthetic wastewater	89:151	Batch adsorption studies on surface tailored chitosan/orange peel hydrogel composite for the removal of Cr(VI) and Cu(II) ions from synthetic wastewater.
33460901	7	63	dep	Cr	1208:1209	arg1	VI					1211:1212	VI	1211:1212	VI	1211:1212	The results concluded that the optimum pH for Cr(VI) and Cu (II) were 4 and 5, contact time: 360 min, adsorbent dosage: 4 g, and initial metal ion concentration: 100 mg/L for each metal ions.
33460901	5	64	theme	X-ray	939:943	arg1	XRD					958:960	XRD	958:960	XRD	958:960	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	5	64	theme	X-ray	939:943	arg1	diffraction					945:955	X-ray diffraction	939:955	X-ray diffraction (XRD)	939:961	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	5	65	theme	X-ray	909:913	arg1	analysis					915:922	Energy dispersive X-ray analysis	891:922	Energy dispersive X-ray analysis	891:922	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	1	66	from	wastewater	187:196	arg1	process					221:227	a significant process	207:227	a significant process to improve the aquatic source's quality	207:267	Elimination of heavy metals from wastewater has been a significant process to improve the aquatic source's quality.
33460901	1	66	from	wastewater	187:196	arg1	Elimination					154:164	Elimination	154:164	Elimination of heavy metals from wastewater	154:196	Elimination of heavy metals from wastewater has been a significant process to improve the aquatic source's quality.
33460901	5	67	theme	Scanning	860:867	arg1	microscopy					878:887	Scanning electron microscopy	860:887	Scanning electron microscopy	860:887	The synthesis of the adsorbent has been confirmed by using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscopy - Energy dispersive X-ray analysis (SEM-EDAX) and X-ray diffraction (XRD) studies.
33460901	3	68	theme	cost-effective	545:558	arg1	composite					584:592	biodegradable and cost-effective chitosan-based hydrogel composite	527:592	biodegradable and cost-effective chitosan-based hydrogel composite	527:592	Thus, the present work focuses on removing heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite.
33460901	3	69	theme	present	418:424	arg1	work					426:429	the present work	414:429	the present work	414:429	Thus, the present work focuses on removing heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite.
33460901	6	70	theme	adsorption	976:985	arg1	power					987:991	The adsorption power	972:991	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations	972:1099	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	6	71	theme	Atomic	1124:1129	arg1	AAS					1156:1158	AAS	1156:1158	AAS	1156:1158	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	6	71	theme	Atomic	1124:1129	arg1	Spectroscopy					1142:1153	Atomic Absorption Spectroscopy	1124:1153	Atomic Absorption Spectroscopy (AAS)	1124:1159	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	8	72	theme	isotherm	1369:1376	arg1	models					1378:1383	The adsorption isotherm models	1354:1383	The adsorption isotherm models	1354:1383	The adsorption isotherm models follow the Freundlich model and pseudo-second-order kinetics.
33460901	3	73	theme	heavy	451:455	arg1	metals					457:462	heavy metals chromium (Cr) and copper (Cu) ions	451:497	heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite	451:592	Thus, the present work focuses on removing heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite.
33460901	6	74	theme	metal	1013:1017	arg1	ions					1019:1022	metal ions	1013:1022	metal ions	1013:1022	The adsorption power of the composite of metal ions at different time, pH, adsorbent dosages, different metal ion concentrations were analyzed by using Atomic Absorption Spectroscopy (AAS).
33460901	0	75	theme	hydrogel	66:73	arg1	composite					75:83	hydrogel composite	66:83	hydrogel composite	66:83	Batch adsorption studies on surface tailored chitosan/orange peel hydrogel composite for the removal of Cr(VI) and Cu(II) ions from synthetic wastewater.
33460901	3	76	theme	biodegradable	527:539	arg1	composite					584:592	biodegradable and cost-effective chitosan-based hydrogel composite	527:592	biodegradable and cost-effective chitosan-based hydrogel composite	527:592	Thus, the present work focuses on removing heavy metals chromium (Cr) and copper (Cu) ions containing wastewater using biodegradable and cost-effective chitosan-based hydrogel composite.
33460901	2	77	theme	living	390:395	arg1	organisms					397:405	all other living organisms	380:405	all other living organisms	380:405	Various materials act as very effective adsorbents to remove heavy metals, which cause toxicity to plants and all other living organisms.
34885735	7	0	theme	bass	1309:1312	arg1	matrix					1314:1319	the sea bass matrix	1301:1319	the sea bass matrix	1301:1319	CI and Ty sustained the release to the sea bass matrix with a similar behavior to the release to 95% ethanol.
34885735	4	1	theme	dry	753:755	arg1	simulant					762:769	solid dry food simulant	747:769	solid dry food simulant (modified polyphenylene oxide (Tenax TA))	747:811	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	2	theme	release	885:891	arg1	behaviors					893:901	the release behaviors	881:901	the release behaviors of bilayer films	881:918	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	3	3	theme	bilayer	621:627	arg1	film					629:632	the active bilayer film	610:632	the active bilayer film	610:632	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty was coated on the surface of PLA film to obtain the active bilayer film.
34885735	8	4	theme	release	1507:1513	arg1	efficiency					1515:1524	the higher release efficiency	1496:1524	the higher release efficiency of Ty in test mediums	1496:1546	The bilayer film containing β-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.
34885735	8	5	theme	antioxidant	1456:1466	arg1	activities					1468:1477	antioxidant activities	1456:1477	antioxidant activities	1456:1477	The bilayer film containing β-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.
34885735	3	6	theme	alginate	506:513	arg1	FGSA					526:529	The tilapia fish gelatin-sodium alginate composite (FGSA)	474:530	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty	474:560	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty was coated on the surface of PLA film to obtain the active bilayer film.
34885735	3	7	theme	fish	486:489	arg1	FGSA					526:529	The tilapia fish gelatin-sodium alginate composite (FGSA)	474:530	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty	474:560	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty was coated on the surface of PLA film to obtain the active bilayer film.
34885735	4	8	theme	Tenax	802:806	arg1	oxide					795:799	modified polyphenylene oxide	772:799	modified polyphenylene oxide (Tenax TA)	772:810	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	8	theme	Tenax	802:806	arg1	TA					808:809	Tenax TA	802:809	Tenax TA	802:809	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	0	9	theme	Food	117:120	arg1	Simulants					122:130	Liquid and Solid Food Simulants	100:130	Liquid and Solid Food Simulants	100:130	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	0	10	dep	Study	170:174	arg1	Release					0:6	Release	0:6	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass	0:153	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	6	11	theme	lowest	1174:1179	arg1	rates					1189:1193	the lowest release rates	1170:1193	the lowest release rates in Tenax TA	1170:1205	Active compounds possessed the lowest release rates in Tenax TA, compared to the release to liquid simulants and sea bass.
34885735	4	12	theme	modified	772:779	arg1	oxide					795:799	modified polyphenylene oxide	772:799	modified polyphenylene oxide (Tenax TA)	772:810	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	12	theme	modified	772:779	arg1	TA					808:809	Tenax TA	802:809	Tenax TA	802:809	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	0	13	theme	Japanese	137:144	arg1	Bass					150:153	Japanese Sea Bass	137:153	Japanese Sea Bass	137:153	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	4	14	theme	liquid	670:675	arg1	simulants					682:690	liquid food simulants	670:690	liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol)	670:744	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	5	15	theme	bilayer	1128:1134	arg1	films					1136:1140	the bilayer films	1124:1140	the bilayer films	1124:1140	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	6	16	theme	Active	1143:1148	arg1	compounds					1150:1158	Active compounds	1143:1158	Active compounds	1143:1158	Active compounds possessed the lowest release rates in Tenax TA, compared to the release to liquid simulants and sea bass.
34885735	0	17	theme	Gelatin-Sodium	59:72	arg1	Films					91:95	PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films	42:95	PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films	42:95	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	1	18	theme	different	308:316	arg1	matrices					323:330	different food matrices	308:330	different food matrices	308:330	This study aimed to develop an active biodegradable bilayer film and to investigate the release behaviors of active compounds into different food matrices.
34885735	2	19	theme	inclusion	437:445	arg1	complex					447:453	the active β-CD inclusion complex	421:453	the active β-CD inclusion complex (β-CD-CI/β-CD-Ty)	421:471	Cinnamaldehyde (CI) or thymol (Ty) was encapsulated in β-cyclodextrin (β-CD) to prepare the active β-CD inclusion complex (β-CD-CI/β-CD-Ty).
34885735	2	19	theme	inclusion	437:445	arg1	β-CD-CI/β-CD-Ty					456:470	β-CD-CI/β-CD-Ty	456:470	β-CD-CI/β-CD-Ty	456:470	Cinnamaldehyde (CI) or thymol (Ty) was encapsulated in β-cyclodextrin (β-CD) to prepare the active β-CD inclusion complex (β-CD-CI/β-CD-Ty).
34885735	4	20	theme	Different	635:643	arg1	simulants					650:658	Different food simulants	635:658	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass)	635:850	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	20	theme	Different	635:643	arg1	simulant					762:769	solid dry food simulant	747:769	solid dry food simulant (modified polyphenylene oxide (Tenax TA))	747:811	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	20	theme	Different	635:643	arg1	simulants					682:690	liquid food simulants	670:690	liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol)	670:744	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	20	theme	Different	635:643	arg1	food					827:830	the real food	818:830	the real food (Japanese sea bass)	818:850	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	5	21	theme	contact	1107:1113	arg1	angle					1115:1119	contact angle	1107:1119	contact angle	1107:1119	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	0	22	theme	Bilayer	83:89	arg1	Films					91:95	PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films	42:95	PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films	42:95	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	6	23	contain	possessed	1160:1168	arg2	rates					1189:1193	the lowest release rates	1170:1193	the lowest release rates in Tenax TA	1170:1205	Active compounds possessed the lowest release rates in Tenax TA, compared to the release to liquid simulants and sea bass.
34885735	6	23	contain	possessed	1160:1168	arg1	compounds					1150:1158	Active compounds	1143:1158	Active compounds	1143:1158	Active compounds possessed the lowest release rates in Tenax TA, compared to the release to liquid simulants and sea bass.
34885735	4	24	theme	3	700:700	arg1	%					701:701	%	701:701	%	701:701	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	7	25	theme	95	1363:1364	arg1	%					1365:1365	%	1365:1365	%	1365:1365	CI and Ty sustained the release to the sea bass matrix with a similar behavior to the release to 95% ethanol.
34885735	4	26	theme	acetic	703:708	arg1	acid					710:713	3% acetic acid	700:713	3% acetic acid	700:713	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	6	27	theme	Tenax	1198:1202	arg1	TA					1204:1205	Tenax TA	1198:1205	Tenax TA	1198:1205	Active compounds possessed the lowest release rates in Tenax TA, compared to the release to liquid simulants and sea bass.
34885735	4	28	dep	simulant	762:769	arg1	oxide					795:799	modified polyphenylene oxide	772:799	modified polyphenylene oxide (Tenax TA)	772:810	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	28	dep	simulant	762:769	arg1	TA					808:809	Tenax TA	802:809	Tenax TA	802:809	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	5	29	theme	cross-linking	1038:1050	arg1	structure					1052:1060	the cross-linking structure	1034:1060	the cross-linking structure of FGSA	1034:1068	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	0	30	theme	Cinnamaldehyde	11:24	arg1	Release					0:6	Release	0:6	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass	0:153	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	1	31	theme	release	265:271	arg1	behaviors					273:281	the release behaviors	261:281	the release behaviors of active compounds into different food matrices	261:330	This study aimed to develop an active biodegradable bilayer film and to investigate the release behaviors of active compounds into different food matrices.
34885735	2	32	theme	active	425:430	arg1	complex					447:453	the active β-CD inclusion complex	421:453	the active β-CD inclusion complex (β-CD-CI/β-CD-Ty)	421:471	Cinnamaldehyde (CI) or thymol (Ty) was encapsulated in β-cyclodextrin (β-CD) to prepare the active β-CD inclusion complex (β-CD-CI/β-CD-Ty).
34885735	2	32	theme	active	425:430	arg1	β-CD-CI/β-CD-Ty					456:470	β-CD-CI/β-CD-Ty	456:470	β-CD-CI/β-CD-Ty	456:470	Cinnamaldehyde (CI) or thymol (Ty) was encapsulated in β-cyclodextrin (β-CD) to prepare the active β-CD inclusion complex (β-CD-CI/β-CD-Ty).
34885735	3	33	theme	film	595:598	arg1	surface					580:586	the surface	576:586	the surface of PLA film	576:598	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty was coated on the surface of PLA film to obtain the active bilayer film.
34885735	0	34	theme	Thymol	30:35	arg1	Release					0:6	Release	0:6	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass	0:153	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	5	35	theme	β-CD	987:990	arg1	complexes					1002:1010	the prepared β-CD inclusion complexes	974:1010	the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films	974:1140	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	4	36	theme	95	733:734	arg1	%					735:735	%	735:735	%	735:735	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	0	37	theme	PLA/Tilapia	42:52	arg1	Films					91:95	PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films	42:95	PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films	42:95	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	1	38	theme	compounds	293:301	arg1	behaviors					273:281	the release behaviors	261:281	the release behaviors of active compounds into different food matrices	261:330	This study aimed to develop an active biodegradable bilayer film and to investigate the release behaviors of active compounds into different food matrices.
34885735	8	39	theme	bilayer	1380:1386	arg1	β-CD-Ty					1404:1410	The bilayer film containing β-CD-Ty	1376:1410	The bilayer film containing β-CD-Ty	1376:1410	The bilayer film containing β-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.
34885735	3	40	theme	active	614:619	arg1	film					629:632	the active bilayer film	610:632	the active bilayer film	610:632	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty was coated on the surface of PLA film to obtain the active bilayer film.
34885735	4	41	theme	food	935:938	arg1	matrixes					940:947	different food matrixes	925:947	different food matrixes	925:947	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	8	42	theme	containing	1393:1402	arg1	β-CD-Ty					1404:1410	The bilayer film containing β-CD-Ty	1376:1410	The bilayer film containing β-CD-Ty	1376:1410	The bilayer film containing β-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.
34885735	4	43	theme	%	718:718	arg1	ethanol					720:726	10% ethanol	716:726	10% ethanol	716:726	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	7	44	with	release	1290:1296	arg1	behavior					1336:1343	a similar behavior	1326:1343	a similar behavior to the release to 95% ethanol	1326:1373	CI and Ty sustained the release to the sea bass matrix with a similar behavior to the release to 95% ethanol.
34885735	1	45	theme	active	208:213	arg1	film					237:240	an active biodegradable bilayer film	205:240	an active biodegradable bilayer film	205:240	This study aimed to develop an active biodegradable bilayer film and to investigate the release behaviors of active compounds into different food matrices.
34885735	7	46	theme	sea	1305:1307	arg1	matrix					1314:1319	the sea bass matrix	1301:1319	the sea bass matrix	1301:1319	CI and Ty sustained the release to the sea bass matrix with a similar behavior to the release to 95% ethanol.
34885735	1	47	theme	active	286:291	arg1	compounds					293:301	active compounds	286:301	active compounds	286:301	This study aimed to develop an active biodegradable bilayer film and to investigate the release behaviors of active compounds into different food matrices.
34885735	4	48	theme	Japanese	833:840	arg1	food					827:830	the real food	818:830	the real food (Japanese sea bass)	818:850	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	48	theme	Japanese	833:840	arg1	bass					846:849	Japanese sea bass	833:849	Japanese sea bass	833:849	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	0	49	theme	Comparative	158:168	arg1	Study					170:174	A Comparative Study	156:174	A Comparative Study	156:174	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	1	50	theme	bilayer	229:235	arg1	film					237:240	an active biodegradable bilayer film	205:240	an active biodegradable bilayer film	205:240	This study aimed to develop an active biodegradable bilayer film and to investigate the release behaviors of active compounds into different food matrices.
34885735	4	51	theme	solid	747:751	arg1	simulant					762:769	solid dry food simulant	747:769	solid dry food simulant (modified polyphenylene oxide (Tenax TA))	747:811	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	52	theme	bilayer	906:912	arg1	films					914:918	bilayer films	906:918	bilayer films	906:918	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	3	53	contain	containing	532:541	arg2	β-CD-Ty					554:560	β-CD-Ty	554:560	β-CD-Ty	554:560	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty was coated on the surface of PLA film to obtain the active bilayer film.
34885735	3	53	contain	containing	532:541	arg1	FGSA					526:529	The tilapia fish gelatin-sodium alginate composite (FGSA)	474:530	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty	474:560	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty was coated on the surface of PLA film to obtain the active bilayer film.
34885735	3	53	contain	containing	532:541	arg2	β-CD-CI					543:549	β-CD-CI	543:549	β-CD-CI	543:549	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty was coated on the surface of PLA film to obtain the active bilayer film.
34885735	3	54	theme	gelatin-sodium	491:504	arg1	FGSA					526:529	The tilapia fish gelatin-sodium alginate composite (FGSA)	474:530	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty	474:560	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty was coated on the surface of PLA film to obtain the active bilayer film.
34885735	8	55	theme	higher	1500:1505	arg1	efficiency					1515:1524	the higher release efficiency	1496:1524	the higher release efficiency of Ty in test mediums	1496:1546	The bilayer film containing β-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.
34885735	5	56	theme	FGSA	1065:1068	arg1	structure					1052:1060	the cross-linking structure	1034:1060	the cross-linking structure of FGSA	1034:1068	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	4	57	theme	food	757:760	arg1	simulant					762:769	solid dry food simulant	747:769	solid dry food simulant (modified polyphenylene oxide (Tenax TA))	747:811	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	3	58	theme	tilapia	478:484	arg1	FGSA					526:529	The tilapia fish gelatin-sodium alginate composite (FGSA)	474:530	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty	474:560	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty was coated on the surface of PLA film to obtain the active bilayer film.
34885735	6	59	theme	liquid	1235:1240	arg1	simulants					1242:1250	liquid simulants	1235:1250	liquid simulants	1235:1250	Active compounds possessed the lowest release rates in Tenax TA, compared to the release to liquid simulants and sea bass.
34885735	4	60	theme	%	735:735	arg1	ethanol					737:743	95% ethanol	733:743	95% ethanol	733:743	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	8	61	theme	Ty	1529:1530	arg1	efficiency					1515:1524	the higher release efficiency	1496:1524	the higher release efficiency of Ty in test mediums	1496:1546	The bilayer film containing β-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.
34885735	3	62	theme	composite	515:523	arg1	FGSA					526:529	The tilapia fish gelatin-sodium alginate composite (FGSA)	474:530	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty	474:560	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty was coated on the surface of PLA film to obtain the active bilayer film.
34885735	8	63	theme	test	1535:1538	arg1	mediums					1540:1546	test mediums	1535:1546	test mediums	1535:1546	The bilayer film containing β-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.
34885735	0	64	from	Films	91:95	arg1	Release					0:6	Release	0:6	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass	0:153	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	6	65	theme	release	1181:1187	arg1	rates					1189:1193	the lowest release rates	1170:1193	the lowest release rates in Tenax TA	1170:1205	Active compounds possessed the lowest release rates in Tenax TA, compared to the release to liquid simulants and sea bass.
34885735	0	66	theme	Sea	146:148	arg1	Bass					150:153	Japanese Sea Bass	137:153	Japanese Sea Bass	137:153	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	4	67	theme	food	645:648	arg1	simulants					650:658	Different food simulants	635:658	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass)	635:850	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	67	theme	food	645:648	arg1	simulant					762:769	solid dry food simulant	747:769	solid dry food simulant (modified polyphenylene oxide (Tenax TA))	747:811	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	67	theme	food	645:648	arg1	simulants					682:690	liquid food simulants	670:690	liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol)	670:744	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	67	theme	food	645:648	arg1	food					827:830	the real food	818:830	the real food (Japanese sea bass)	818:850	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	68	dep	simulants	682:690	arg1	acid					710:713	3% acetic acid	700:713	3% acetic acid	700:713	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	68	dep	simulants	682:690	arg1	water					693:697	water	693:697	water	693:697	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	68	dep	simulants	682:690	arg1	ethanol					737:743	95% ethanol	733:743	95% ethanol	733:743	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	68	dep	simulants	682:690	arg1	ethanol					720:726	10% ethanol	716:726	10% ethanol	716:726	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	69	theme	polyphenylene	781:793	arg1	oxide					795:799	modified polyphenylene oxide	772:799	modified polyphenylene oxide (Tenax TA)	772:810	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	69	theme	polyphenylene	781:793	arg1	TA					808:809	Tenax TA	802:809	Tenax TA	802:809	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	5	70	theme	films	1136:1140	arg1	water					1101:1105	water	1101:1105	water	1101:1105	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	5	70	theme	films	1136:1140	arg1	thickness					1087:1095	thickness	1087:1095	thickness	1087:1095	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	0	71	theme	Alginate	74:81	arg1	Films					91:95	PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films	42:95	PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films	42:95	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	4	72	theme	real	822:825	arg1	food					827:830	the real food	818:830	the real food (Japanese sea bass)	818:850	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	72	theme	real	822:825	arg1	bass					846:849	Japanese sea bass	833:849	Japanese sea bass	833:849	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	1	73	theme	food	318:321	arg1	matrices					323:330	different food matrices	308:330	different food matrices	308:330	This study aimed to develop an active biodegradable bilayer film and to investigate the release behaviors of active compounds into different food matrices.
34885735	7	74	theme	%	1365:1365	arg1	ethanol					1367:1373	95% ethanol	1363:1373	95% ethanol	1363:1373	CI and Ty sustained the release to the sea bass matrix with a similar behavior to the release to 95% ethanol.
34885735	2	75	theme	β-CD	432:435	arg1	complex					447:453	the active β-CD inclusion complex	421:453	the active β-CD inclusion complex (β-CD-CI/β-CD-Ty)	421:471	Cinnamaldehyde (CI) or thymol (Ty) was encapsulated in β-cyclodextrin (β-CD) to prepare the active β-CD inclusion complex (β-CD-CI/β-CD-Ty).
34885735	2	75	theme	β-CD	432:435	arg1	β-CD-CI/β-CD-Ty					456:470	β-CD-CI/β-CD-Ty	456:470	β-CD-CI/β-CD-Ty	456:470	Cinnamaldehyde (CI) or thymol (Ty) was encapsulated in β-cyclodextrin (β-CD) to prepare the active β-CD inclusion complex (β-CD-CI/β-CD-Ty).
34885735	5	76	dep	thickness	1087:1095	arg1	angle					1115:1119	contact angle	1107:1119	contact angle	1107:1119	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	5	76	dep	thickness	1087:1095	arg1	the					1083:1085	the	1083:1085	the	1083:1085	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	0	77	theme	Liquid	100:105	arg1	Simulants					122:130	Liquid and Solid Food Simulants	100:130	Liquid and Solid Food Simulants	100:130	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	5	78	theme	prepared	978:985	arg1	complexes					1002:1010	the prepared β-CD inclusion complexes	974:1010	the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films	974:1140	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	5	79	dep	complexes	1002:1010	arg1	distributed					1012:1022	distributed	1012:1022	distributed evenly in the cross-linking structure of FGSA	1012:1068	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	5	79	dep	complexes	1002:1010	arg1	improved					1074:1081	improved	1074:1081	improved the thickness and water contact angle of the bilayer films	1074:1140	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	0	80	theme	Solid	111:115	arg1	Simulants					122:130	Liquid and Solid Food Simulants	100:130	Liquid and Solid Food Simulants	100:130	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	4	81	theme	%	701:701	arg1	acid					710:713	3% acetic acid	700:713	3% acetic acid	700:713	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	82	theme	food	677:680	arg1	simulants					682:690	liquid food simulants	670:690	liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol)	670:744	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	8	83	from	mediums	1540:1546	arg1	efficiency					1515:1524	the higher release efficiency	1496:1524	the higher release efficiency of Ty in test mediums	1496:1546	The bilayer film containing β-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.
34885735	5	84	dep	showed	962:967	arg1	complexes					1002:1010	the prepared β-CD inclusion complexes	974:1010	the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films	974:1140	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	3	85	theme	PLA	591:593	arg1	film					595:598	PLA film	591:598	PLA film	591:598	The tilapia fish gelatin-sodium alginate composite (FGSA) containing β-CD-CI or β-CD-Ty was coated on the surface of PLA film to obtain the active bilayer film.
34885735	6	86	theme	sea	1256:1258	arg1	bass					1260:1263	sea bass	1256:1263	sea bass	1256:1263	Active compounds possessed the lowest release rates in Tenax TA, compared to the release to liquid simulants and sea bass.
34885735	6	87	from	rates	1189:1193	arg1	TA					1204:1205	Tenax TA	1198:1205	Tenax TA	1198:1205	Active compounds possessed the lowest release rates in Tenax TA, compared to the release to liquid simulants and sea bass.
34885735	4	88	theme	sea	842:844	arg1	food					827:830	the real food	818:830	the real food (Japanese sea bass)	818:850	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	88	theme	sea	842:844	arg1	bass					846:849	Japanese sea bass	833:849	Japanese sea bass	833:849	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	8	89	from	Ty	1529:1530	arg1	mediums					1540:1546	test mediums	1535:1546	test mediums	1535:1546	The bilayer film containing β-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.
34885735	0	90	theme	Fish	54:57	arg1	Films					91:95	PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films	42:95	PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films	42:95	Release of Cinnamaldehyde and Thymol from PLA/Tilapia Fish Gelatin-Sodium Alginate Bilayer Films to Liquid and Solid Food Simulants, and Japanese Sea Bass: A Comparative Study.
34885735	5	91	theme	inclusion	992:1000	arg1	complexes					1002:1010	the prepared β-CD inclusion complexes	974:1010	the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films	974:1140	The results showed that the prepared β-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films.
34885735	8	92	theme	film	1388:1391	arg1	β-CD-Ty					1404:1410	The bilayer film containing β-CD-Ty	1376:1410	The bilayer film containing β-CD-Ty	1376:1410	The bilayer film containing β-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.
34885735	8	93	from	efficiency	1515:1524	arg1	mediums					1540:1546	test mediums	1535:1546	test mediums	1535:1546	The bilayer film containing β-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.
34885735	8	94	theme	active	1431:1436	arg1	antibacterial					1438:1450	stronger active antibacterial	1422:1450	stronger active antibacterial	1422:1450	The bilayer film containing β-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.
34885735	7	95	theme	similar	1328:1334	arg1	behavior					1336:1343	a similar behavior	1326:1343	a similar behavior to the release to 95% ethanol	1326:1373	CI and Ty sustained the release to the sea bass matrix with a similar behavior to the release to 95% ethanol.
34885735	4	96	theme	films	914:918	arg1	behaviors					893:901	the release behaviors	881:901	the release behaviors of bilayer films	881:918	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	4	97	theme	different	925:933	arg1	matrixes					940:947	different food matrixes	925:947	different food matrixes	925:947	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	8	98	theme	stronger	1422:1429	arg1	antibacterial					1438:1450	stronger active antibacterial	1422:1450	stronger active antibacterial	1422:1450	The bilayer film containing β-CD-Ty exhibited stronger active antibacterial and antioxidant activities, probably due to the higher release efficiency of Ty in test mediums.
34885735	4	99	theme	10	716:717	arg1	%					718:718	%	718:718	%	718:718	Different food simulants including liquid food simulants (water, 3% acetic acid, 10% ethanol, and 95% ethanol), solid dry food simulant (modified polyphenylene oxide (Tenax TA)), and the real food (Japanese sea bass) were selected to investigate the release behaviors of bilayer films into different food matrixes.
34885735	1	100	theme	biodegradable	215:227	arg1	film					237:240	an active biodegradable bilayer film	205:240	an active biodegradable bilayer film	205:240	This study aimed to develop an active biodegradable bilayer film and to investigate the release behaviors of active compounds into different food matrices.
34473428	0	0	theme	Proregenerative	95:109	arg1	Performances					111:122	Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances	31:122	Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances	31:122	Polymer Composite Sponges with Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances for Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing.
34473428	2	1	theme	salts-conjugated	563:578	arg1	chitosan					580:587	double quaternary ammonium salts-conjugated chitosan	536:587	double quaternary ammonium salts-conjugated chitosan (QAS-CS)	536:596	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	2	1	theme	salts-conjugated	563:578	arg1	QAS-CS					590:595	QAS-CS	590:595	QAS-CS	590:595	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	4	2	theme	components	1212:1221	arg1	leakage					1191:1197	the leakage	1187:1197	the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial	1187:1286	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	2	3	theme	accelerating	413:424	arg1	healing					466:472	accelerating drug-resistant bacterial infected wound healing	413:472	accelerating drug-resistant bacterial infected wound healing	413:472	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	1	4	theme	difficult	298:306	arg1	healing					314:320	difficult wound healing	298:320	difficult wound healing after tissue trauma	298:340	Clinical wound management remains a major challenge due to massive bleeding, bacterial infection, and difficult wound healing after tissue trauma.
34473428	2	5	theme	ammonium	554:561	arg1	chitosan					580:587	double quaternary ammonium salts-conjugated chitosan	536:587	double quaternary ammonium salts-conjugated chitosan (QAS-CS)	536:596	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	2	5	theme	ammonium	554:561	arg1	QAS-CS					590:595	QAS-CS	590:595	QAS-CS	590:595	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	3	6	theme	porosity	744:751	arg1	%					756:756	porosity ≈90%	744:756	porosity ≈90%	744:756	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	6	theme	porosity	744:751	arg1	microstructures					727:741	highly porous microstructures	713:741	highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%)	713:863	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	1	7	theme	wound	308:312	arg1	healing					314:320	difficult wound healing	298:320	difficult wound healing after tissue trauma	298:340	Clinical wound management remains a major challenge due to massive bleeding, bacterial infection, and difficult wound healing after tissue trauma.
34473428	6	8	theme	wound	1455:1459	arg1	regeneration					1405:1416	the regeneration	1401:1416	the regeneration of MRSA-infected full-thickness skin wound in rabbit	1401:1469	Significantly, the sponge greatly expedites the regeneration of MRSA-infected full-thickness skin wound in rabbit by successfully eradicating bacterial infection, and reducing inflammation.
34473428	7	9	theme	early	1577:1581	arg1	angiogenesis					1583:1594	early angiogenesis	1577:1594	early angiogenesis	1577:1594	PQC sponge also improves both early angiogenesis and blood vessel maturation at the wound site.
34473428	4	10	theme	PQC	879:881	arg1	sponge					883:888	PQC sponge	879:888	PQC sponge	879:888	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	4	11	theme	hemostasis	912:921	arg1	ability					923:929	superior hemostasis ability	903:929	superior hemostasis ability	903:929	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	8	12	theme	great	1737:1741	arg1	potential					1743:1751	great potential	1737:1751	great potential for rapid clinical translation	1737:1782	Overall, this multifunctional sponge is a promising wound dressing for clinical use and holds great potential for rapid clinical translation.
34473428	4	13	theme	CS	959:960	arg1	sponge					962:967	commercially available CS sponge	936:967	commercially available CS sponge	936:967	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	3	14	theme	compress	773:780	arg1	MPa					796:798	≈0.3 MPa	791:798	≈0.3 MPa	791:798	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	14	theme	compress	773:780	arg1	modulus					782:788	moderate compress modulus	764:788	moderate compress modulus (≈0.3 MPa)	764:799	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	15	theme	high	836:839	arg1	%					862:862	≈3500%	857:862	≈3500%	857:862	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	15	theme	high	836:839	arg1	ratio					850:854	high swelling ratio	836:854	high swelling ratio (≈3500%)	836:863	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	6	16	theme	full-thickness	1435:1448	arg1	wound					1455:1459	MRSA-infected full-thickness skin wound	1421:1459	MRSA-infected full-thickness skin wound	1421:1459	Significantly, the sponge greatly expedites the regeneration of MRSA-infected full-thickness skin wound in rabbit by successfully eradicating bacterial infection, and reducing inflammation.
34473428	3	17	dep	sponges	677:683	arg1	PQC					703:705	PQC	703:705	PQC	703:705	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	17	dep	sponges	677:683	arg1	PAAS/QAS-CS/COL					686:700	PAAS/QAS-CS/COL	686:700	PAAS/QAS-CS/COL	686:700	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	8	18	theme	clinical	1763:1770	arg1	translation					1772:1782	rapid clinical translation	1757:1782	rapid clinical translation	1757:1782	Overall, this multifunctional sponge is a promising wound dressing for clinical use and holds great potential for rapid clinical translation.
34473428	6	19	theme	MRSA-infected	1421:1433	arg1	wound					1455:1459	MRSA-infected full-thickness skin wound	1421:1459	MRSA-infected full-thickness skin wound	1421:1459	Significantly, the sponge greatly expedites the regeneration of MRSA-infected full-thickness skin wound in rabbit by successfully eradicating bacterial infection, and reducing inflammation.
34473428	7	20	theme	PQC	1547:1549	arg1	sponge					1551:1556	PQC sponge	1547:1556	PQC sponge	1547:1556	PQC sponge also improves both early angiogenesis and blood vessel maturation at the wound site.
34473428	0	21	theme	Antibacterial	40:52	arg1	Performances					111:122	Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances	31:122	Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances	31:122	Polymer Composite Sponges with Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances for Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing.
34473428	3	22	with	microstructures	727:741	arg1	modulus					782:788	moderate compress modulus	764:788	moderate compress modulus (≈0.3 MPa)	764:799	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	22	with	microstructures	727:741	arg1	%					862:862	≈3500%	857:862	≈3500%	857:862	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	22	with	microstructures	727:741	arg1	strength					810:817	tensile strength	802:817	tensile strength (0.004 MPa)	802:829	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	22	with	microstructures	727:741	arg1	ratio					850:854	high swelling ratio	836:854	high swelling ratio (≈3500%)	836:863	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	22	with	microstructures	727:741	arg1	MPa					796:798	≈0.3 MPa	791:798	≈0.3 MPa	791:798	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	22	with	microstructures	727:741	arg1	MPa					826:828	0.004 MPa	820:828	0.004 MPa	820:828	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	1	23	theme	major	232:236	arg1	challenge					238:246	a major challenge	230:246	a major challenge due to massive bleeding, bacterial infection, and difficult wound healing after tissue trauma	230:340	Clinical wound management remains a major challenge due to massive bleeding, bacterial infection, and difficult wound healing after tissue trauma.
34473428	0	24	theme	Composite	8:16	arg1	Sponges					18:24	Polymer Composite Sponges	0:24	Polymer Composite Sponges with Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances for Methicillin-Resistant Staphylococcus	0:163	Polymer Composite Sponges with Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances for Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing.
34473428	3	25	theme	moderate	764:771	arg1	MPa					796:798	≈0.3 MPa	791:798	≈0.3 MPa	791:798	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	25	theme	moderate	764:771	arg1	modulus					782:788	moderate compress modulus	764:788	moderate compress modulus (≈0.3 MPa)	764:799	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	8	26	theme	promising	1685:1693	arg1	dressing					1701:1708	a promising wound dressing	1683:1708	a promising wound dressing for clinical use	1683:1725	Overall, this multifunctional sponge is a promising wound dressing for clinical use and holds great potential for rapid clinical translation.
34473428	8	26	theme	promising	1685:1693	arg1	sponge					1673:1678	this multifunctional sponge	1652:1678	this multifunctional sponge	1652:1678	Overall, this multifunctional sponge is a promising wound dressing for clinical use and holds great potential for rapid clinical translation.
34473428	4	27	from	bacterial	1278:1286	arg1	β-galactosidase					1249:1263	β-galactosidase	1249:1263	β-galactosidase	1249:1263	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	4	27	from	bacterial	1278:1286	arg1	ion					1241:1243	potassium ion	1231:1243	potassium ion	1231:1243	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	2	28	theme	wound	460:464	arg1	healing					466:472	accelerating drug-resistant bacterial infected wound healing	413:472	accelerating drug-resistant bacterial infected wound healing	413:472	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	0	29	theme	Polymer	0:6	arg1	Sponges					18:24	Polymer Composite Sponges	0:24	Polymer Composite Sponges with Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances for Methicillin-Resistant Staphylococcus	0:163	Polymer Composite Sponges with Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances for Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing.
34473428	1	30	theme	tissue	328:333	arg1	trauma					335:340	tissue trauma	328:340	tissue trauma	328:340	Clinical wound management remains a major challenge due to massive bleeding, bacterial infection, and difficult wound healing after tissue trauma.
34473428	7	31	theme	vessel	1606:1611	arg1	maturation					1613:1622	blood vessel maturation	1600:1622	blood vessel maturation	1600:1622	PQC sponge also improves both early angiogenesis and blood vessel maturation at the wound site.
34473428	4	32	theme	antibacterial	1039:1051	arg1	activity					1053:1060	significantly better antibacterial activity	1018:1060	significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli	1018:1145	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	1	33	theme	due	248:250	arg1	challenge					238:246	a major challenge	230:246	a major challenge due to massive bleeding, bacterial infection, and difficult wound healing after tissue trauma	230:340	Clinical wound management remains a major challenge due to massive bleeding, bacterial infection, and difficult wound healing after tissue trauma.
34473428	0	34	theme	Wound	181:185	arg1	Healing					187:193	Wound Healing	181:193	Wound Healing	181:193	Polymer Composite Sponges with Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances for Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing.
34473428	2	35	theme	sodium	508:513	arg1	PAAS					529:532	PAAS	529:532	PAAS	529:532	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	2	35	theme	sodium	508:513	arg1	polyacrylate					515:526	sodium polyacrylate	508:526	sodium polyacrylate (PAAS)	508:533	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	8	36	theme	multifunctional	1657:1671	arg1	dressing					1701:1708	a promising wound dressing	1683:1708	a promising wound dressing for clinical use	1683:1725	Overall, this multifunctional sponge is a promising wound dressing for clinical use and holds great potential for rapid clinical translation.
34473428	8	36	theme	multifunctional	1657:1671	arg1	sponge					1673:1678	this multifunctional sponge	1652:1678	this multifunctional sponge	1652:1678	Overall, this multifunctional sponge is a promising wound dressing for clinical use and holds great potential for rapid clinical translation.
34473428	4	37	theme	cell	1161:1164	arg1	membrane					1166:1173	cell membrane	1161:1173	cell membrane	1161:1173	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	2	38	theme	bacterial	441:449	arg1	healing					466:472	accelerating drug-resistant bacterial infected wound healing	413:472	accelerating drug-resistant bacterial infected wound healing	413:472	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	2	39	theme	quaternary	543:552	arg1	chitosan					580:587	double quaternary ammonium salts-conjugated chitosan	536:587	double quaternary ammonium salts-conjugated chitosan (QAS-CS)	536:596	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	2	39	theme	quaternary	543:552	arg1	QAS-CS					590:595	QAS-CS	590:595	QAS-CS	590:595	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	6	40	from	regeneration	1405:1416	arg1	rabbit					1464:1469	rabbit	1464:1469	rabbit	1464:1469	Significantly, the sponge greatly expedites the regeneration of MRSA-infected full-thickness skin wound in rabbit by successfully eradicating bacterial infection, and reducing inflammation.
34473428	4	41	theme	available	949:957	arg1	sponge					962:967	commercially available CS sponge	936:967	commercially available CS sponge	936:967	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	2	42	theme	infected	451:458	arg1	healing					466:472	accelerating drug-resistant bacterial infected wound healing	413:472	accelerating drug-resistant bacterial infected wound healing	413:472	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	0	43	theme	Inherent	31:38	arg1	Performances					111:122	Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances	31:122	Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances	31:122	Polymer Composite Sponges with Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances for Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing.
34473428	7	44	from	site	1637:1640	arg1	maturation					1613:1622	blood vessel maturation	1600:1622	blood vessel maturation	1600:1622	PQC sponge also improves both early angiogenesis and blood vessel maturation at the wound site.
34473428	7	44	from	site	1637:1640	arg1	angiogenesis					1583:1594	early angiogenesis	1577:1594	early angiogenesis	1577:1594	PQC sponge also improves both early angiogenesis and blood vessel maturation at the wound site.
34473428	2	45	theme	double	536:541	arg1	chitosan					580:587	double quaternary ammonium salts-conjugated chitosan	536:587	double quaternary ammonium salts-conjugated chitosan (QAS-CS)	536:596	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	2	45	theme	double	536:541	arg1	QAS-CS					590:595	QAS-CS	590:595	QAS-CS	590:595	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	4	46	theme	potassium	1231:1239	arg1	ion					1241:1243	potassium ion	1231:1243	potassium ion	1231:1243	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	0	47	theme	Hemostatic	55:64	arg1	Performances					111:122	Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances	31:122	Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances	31:122	Polymer Composite Sponges with Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances for Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing.
34473428	7	48	theme	wound	1631:1635	arg1	site					1637:1640	the wound site	1627:1640	the wound site	1627:1640	PQC sponge also improves both early angiogenesis and blood vessel maturation at the wound site.
34473428	0	49	with	Sponges	18:24	arg1	Performances					111:122	Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances	31:122	Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances	31:122	Polymer Composite Sponges with Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances for Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing.
34473428	4	50	theme	better	1032:1037	arg1	activity					1053:1060	significantly better antibacterial activity	1018:1060	significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli	1018:1145	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	6	51	theme	bacterial	1499:1507	arg1	infection					1509:1517	bacterial infection	1499:1517	bacterial infection	1499:1517	Significantly, the sponge greatly expedites the regeneration of MRSA-infected full-thickness skin wound in rabbit by successfully eradicating bacterial infection, and reducing inflammation.
34473428	2	52	theme	polymer	393:399	arg1	sponges					401:407	composite polymer sponges	383:407	composite polymer sponges for accelerating drug-resistant bacterial infected wound healing	383:472	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	5	53	theme	cell	1337:1340	arg1	proliferation					1342:1354	cell proliferation	1337:1354	cell proliferation	1337:1354	Furthermore, PQC sponge can efficiently promote cell proliferation.
34473428	3	54	theme	tensile	802:808	arg1	strength					810:817	tensile strength	802:817	tensile strength (0.004 MPa)	802:829	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	54	theme	tensile	802:808	arg1	MPa					826:828	0.004 MPa	820:828	0.004 MPa	820:828	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	2	55	theme	aqueous	621:627	arg1	solution					629:636	aqueous solution	621:636	aqueous solution	621:636	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	2	56	theme	composite	383:391	arg1	sponges					401:407	composite polymer sponges	383:407	composite polymer sponges for accelerating drug-resistant bacterial infected wound healing	383:472	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	1	57	theme	bacterial	273:281	arg1	infection					283:291	bacterial infection	273:291	bacterial infection	273:291	Clinical wound management remains a major challenge due to massive bleeding, bacterial infection, and difficult wound healing after tissue trauma.
34473428	4	58	theme	superior	903:910	arg1	ability					923:929	superior hemostasis ability	903:929	superior hemostasis ability	903:929	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	7	59	theme	blood	1600:1604	arg1	maturation					1613:1622	blood vessel maturation	1600:1622	blood vessel maturation	1600:1622	PQC sponge also improves both early angiogenesis and blood vessel maturation at the wound site.
34473428	3	60	theme	swelling	841:848	arg1	%					862:862	≈3500%	857:862	≈3500%	857:862	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	60	theme	swelling	841:848	arg1	ratio					850:854	high swelling ratio	836:854	high swelling ratio (≈3500%)	836:863	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	2	61	theme	drug-resistant	426:439	arg1	healing					466:472	accelerating drug-resistant bacterial infected wound healing	413:472	accelerating drug-resistant bacterial infected wound healing	413:472	To simultaneously address these issues, composite polymer sponges for accelerating drug-resistant bacterial infected wound healing are fabricated by facilely mixing sodium polyacrylate (PAAS), double quaternary ammonium salts-conjugated chitosan (QAS-CS), and collagen (COL) in aqueous solution, followed by lyophilization.
34473428	6	62	theme	skin	1450:1453	arg1	wound					1455:1459	MRSA-infected full-thickness skin wound	1421:1459	MRSA-infected full-thickness skin wound	1421:1459	Significantly, the sponge greatly expedites the regeneration of MRSA-infected full-thickness skin wound in rabbit by successfully eradicating bacterial infection, and reducing inflammation.
34473428	8	63	theme	wound	1695:1699	arg1	dressing					1701:1708	a promising wound dressing	1683:1708	a promising wound dressing for clinical use	1683:1725	Overall, this multifunctional sponge is a promising wound dressing for clinical use and holds great potential for rapid clinical translation.
34473428	8	63	theme	wound	1695:1699	arg1	sponge					1673:1678	this multifunctional sponge	1652:1678	this multifunctional sponge	1652:1678	Overall, this multifunctional sponge is a promising wound dressing for clinical use and holds great potential for rapid clinical translation.
34473428	0	64	theme	Inflammation-Modulating	67:89	arg1	Performances					111:122	Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances	31:122	Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances	31:122	Polymer Composite Sponges with Inherent Antibacterial, Hemostatic, Inflammation-Modulating and Proregenerative Performances for Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing.
34473428	3	65	theme	porous	720:725	arg1	%					756:756	porosity ≈90%	744:756	porosity ≈90%	744:756	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	65	theme	porous	720:725	arg1	microstructures					727:741	highly porous microstructures	713:741	highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%)	713:863	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	3	66	theme	Composite	667:675	arg1	sponges					677:683	Composite sponges	667:683	Composite sponges (PAAS/QAS-CS/COL, PQC)	667:706	Composite sponges (PAAS/QAS-CS/COL, PQC) show highly porous microstructures (porosity ≈90%) with moderate compress modulus (≈0.3 MPa), tensile strength (0.004 MPa), and high swelling ratio (≈3500%).
34473428	4	67	theme	bioactive	1202:1210	arg1	components					1212:1221	bioactive components	1202:1221	bioactive components such as potassium ion and β-galactosidase from treated bacterial	1202:1286	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	4	67	theme	bioactive	1202:1210	arg1	β-galactosidase					1249:1263	β-galactosidase	1249:1263	β-galactosidase	1249:1263	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	4	67	theme	bioactive	1202:1210	arg1	ion					1241:1243	potassium ion	1231:1243	potassium ion	1231:1243	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	1	68	theme	Clinical	196:203	arg1	management					211:220	Clinical wound management	196:220	Clinical wound management	196:220	Clinical wound management remains a major challenge due to massive bleeding, bacterial infection, and difficult wound healing after tissue trauma.
34473428	8	69	theme	rapid	1757:1761	arg1	translation					1772:1782	rapid clinical translation	1757:1782	rapid clinical translation	1757:1782	Overall, this multifunctional sponge is a promising wound dressing for clinical use and holds great potential for rapid clinical translation.
34473428	8	70	theme	clinical	1714:1721	arg1	use					1723:1725	clinical use	1714:1725	clinical use	1714:1725	Overall, this multifunctional sponge is a promising wound dressing for clinical use and holds great potential for rapid clinical translation.
34473428	4	71	theme	rapid	981:985	arg1	hemagglutination					987:1002	rapid hemagglutination	981:1002	rapid hemagglutination	981:1002	Importantly, PQC sponge demonstrates superior hemostasis ability over commercially available CS sponge by inducing rapid hemagglutination, and exhibits significantly better antibacterial activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli by destroying cell membrane and causing the leakage of bioactive components such as potassium ion and β-galactosidase from treated bacterial.
34473428	1	72	theme	wound	205:209	arg1	management					211:220	Clinical wound management	196:220	Clinical wound management	196:220	Clinical wound management remains a major challenge due to massive bleeding, bacterial infection, and difficult wound healing after tissue trauma.
34473428	5	73	theme	PQC	1302:1304	arg1	sponge					1306:1311	PQC sponge	1302:1311	PQC sponge	1302:1311	Furthermore, PQC sponge can efficiently promote cell proliferation.
33153040	0	0	theme	Combined	80:87	arg1	Process					89:95	a Novel Combined Process	72:95	a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching	72:149	Porous Silk Fibroin/Cellulose Hydrogels for Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching.
33153040	9	1	theme	cells	1460:1464	arg1	differentiation					1435:1449	the differentiation	1431:1449	the differentiation of MC3T3 cells to osteoblasts	1431:1479	The hydrogels support the differentiation of MC3T3 cells to osteoblasts and are expected to be a good scaffold for bone tissue engineering.
33153040	1	2	theme	bone	245:248	arg1	cells					250:254	bone cells	245:254	bone cells	245:254	Scaffolds used for bone tissue engineering need to have a variety of features to accommodate bone cells.
33153040	0	3	theme	Novel	74:78	arg1	Process					89:95	a Novel Combined Process	72:95	a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching	72:149	Porous Silk Fibroin/Cellulose Hydrogels for Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching.
33153040	3	4	theme	bone	652:655	arg1	engineering					664:674	bone tissue engineering	652:674	bone tissue engineering	652:674	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	3	5	theme	tissue	657:662	arg1	engineering					664:674	bone tissue engineering	652:674	bone tissue engineering	652:674	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	3	6	from	aim	491:493	arg1	work					482:485	this work	477:485	this work	477:485	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	2	7	theme	natural	283:289	arg1	bone					291:294	natural bone	283:294	natural bone	283:294	The scaffold should mimic natural bone, it should have appropriate mechanical strength, support cell differentiation to the osteogenic lineage, and offer adequate porosity to allow vascularization and bone in-growth.
33153040	9	8	theme	good	1506:1509	arg1	scaffold					1511:1518	a good scaffold	1504:1518	a good scaffold for bone tissue engineering	1504:1546	The hydrogels support the differentiation of MC3T3 cells to osteoblasts and are expected to be a good scaffold for bone tissue engineering.
33153040	9	8	theme	good	1506:1509	arg1	hydrogels					1413:1421	The hydrogels	1409:1421	The hydrogels	1409:1421	The hydrogels support the differentiation of MC3T3 cells to osteoblasts and are expected to be a good scaffold for bone tissue engineering.
33153040	5	9	theme	embedded	1055:1062	arg1	structure					1045:1053	a cellulose framework structure	1023:1053	a cellulose framework structure embedded in a silk fibroin matrix	1023:1087	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	0	10	theme	Sequential	106:115	arg1	Regeneration					117:128	Sequential Regeneration	106:128	Sequential Regeneration	106:128	Porous Silk Fibroin/Cellulose Hydrogels for Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching.
33153040	7	11	theme	cellulose	1189:1197	arg1	composition					1199:1209	The cellulose composition	1185:1209	The cellulose composition	1185:1209	The cellulose composition results in improving the mechanical properties for the hydrogels in comparison to the silk fibroin control material.
33153040	5	12	theme	remaining	939:947	arg1	fibroin					954:960	the remaining silk fibroin	935:960	the remaining silk fibroin in the hydrogel	935:976	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	1	13	theme	bone	171:174	arg1	engineering					183:193	bone tissue engineering	171:193	bone tissue engineering	171:193	Scaffolds used for bone tissue engineering need to have a variety of features to accommodate bone cells.
33153040	4	14	dep	dissolved	713:721	arg1	both					708:711	both	708:711	both	708:711	Silk fibroin and cellulose are both dissolved together in N,N-dimethylacetamide/LiCl and molded to a porous structure using NaCl powder.
33153040	5	15	theme	fibroin	1074:1080	arg1	matrix					1082:1087	a silk fibroin matrix	1067:1087	a silk fibroin matrix	1067:1087	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	3	16	theme	new	511:513	arg1	process					515:521	a new process	509:521	a new process	509:521	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	5	17	from	fibroin	954:960	arg1	hydrogel					969:976	the hydrogel	965:976	the hydrogel	965:976	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	1	18	theme	tissue	176:181	arg1	engineering					183:193	bone tissue engineering	171:193	bone tissue engineering	171:193	Scaffolds used for bone tissue engineering need to have a variety of features to accommodate bone cells.
33153040	0	19	theme	Silk	7:10	arg1	Hydrogels					30:38	Porous Silk Fibroin/Cellulose Hydrogels	0:38	Porous Silk Fibroin/Cellulose Hydrogels for Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching.	0:150	Porous Silk Fibroin/Cellulose Hydrogels for Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching.
33153040	5	20	theme	silk	1069:1072	arg1	matrix					1082:1087	a silk fibroin matrix	1067:1087	a silk fibroin matrix	1067:1087	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	5	21	theme	water	906:910	arg1	treatment					918:926	water vapor treatment	906:926	water vapor treatment	906:926	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	0	22	theme	Porous	0:5	arg1	Hydrogels					30:38	Porous Silk Fibroin/Cellulose Hydrogels	0:38	Porous Silk Fibroin/Cellulose Hydrogels for Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching.	0:150	Porous Silk Fibroin/Cellulose Hydrogels for Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching.
33153040	5	23	theme	vapor	912:916	arg1	treatment					918:926	water vapor treatment	906:926	water vapor treatment	906:926	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	9	24	theme	MC3T3	1454:1458	arg1	cells					1460:1464	MC3T3 cells	1454:1464	MC3T3 cells	1454:1464	The hydrogels support the differentiation of MC3T3 cells to osteoblasts and are expected to be a good scaffold for bone tissue engineering.
33153040	5	25	from	embedded	1055:1062	arg1	matrix					1082:1087	a silk fibroin matrix	1067:1087	a silk fibroin matrix	1067:1087	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	8	26	theme	pore	1332:1335	arg1	size					1337:1340	The pore size	1328:1340	The pore size	1328:1340	The pore size and porosity are estimated at around 350 µm and 70%, respectively.
33153040	2	27	theme	adequate	411:418	arg1	porosity					420:427	adequate porosity	411:427	adequate porosity	411:427	The scaffold should mimic natural bone, it should have appropriate mechanical strength, support cell differentiation to the osteogenic lineage, and offer adequate porosity to allow vascularization and bone in-growth.
33153040	0	28	theme	Fibroin/Cellulose	12:28	arg1	Hydrogels					30:38	Porous Silk Fibroin/Cellulose Hydrogels	0:38	Porous Silk Fibroin/Cellulose Hydrogels for Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching.	0:150	Porous Silk Fibroin/Cellulose Hydrogels for Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching.
33153040	3	29	theme	such	536:539	arg1	materials					541:549	such materials	536:549	such materials	536:549	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	7	30	theme	control	1310:1316	arg1	material					1318:1325	the silk fibroin control material	1293:1325	the silk fibroin control material	1293:1325	The cellulose composition results in improving the mechanical properties for the hydrogels in comparison to the silk fibroin control material.
33153040	0	31	theme	Bone	44:47	arg1	Engineering					56:66	Bone Tissue Engineering	44:66	Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching	44:149	Porous Silk Fibroin/Cellulose Hydrogels for Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching.
33153040	4	32	theme	Silk	677:680	arg1	fibroin					682:688	Silk fibroin	677:688	Silk fibroin	677:688	Silk fibroin and cellulose are both dissolved together in N,N-dimethylacetamide/LiCl and molded to a porous structure using NaCl powder.
33153040	5	33	theme	cellulose	1025:1033	arg1	structure					1045:1053	a cellulose framework structure	1023:1053	a cellulose framework structure embedded in a silk fibroin matrix	1023:1087	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	3	34	theme	porous	565:570	arg1	scaffold					640:647	a suitable scaffold	629:647	a suitable scaffold of bone tissue engineering	629:674	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	3	34	theme	porous	565:570	arg1	material					582:589	a porous composite material	563:589	a porous composite material made of silk fibroin and cellulose	563:624	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	7	35	theme	mechanical	1236:1245	arg1	properties					1247:1256	the mechanical properties	1232:1256	the mechanical properties for the hydrogels in comparison to the silk fibroin control material	1232:1325	The cellulose composition results in improving the mechanical properties for the hydrogels in comparison to the silk fibroin control material.
33153040	0	36	theme	Porogen	134:140	arg1	Leaching					142:149	Porogen Leaching	134:149	Porogen Leaching	134:149	Porous Silk Fibroin/Cellulose Hydrogels for Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching.
33153040	5	37	theme	framework	1035:1043	arg1	structure					1045:1053	a cellulose framework structure	1023:1053	a cellulose framework structure embedded in a silk fibroin matrix	1023:1087	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	3	38	theme	composite	572:580	arg1	scaffold					640:647	a suitable scaffold	629:647	a suitable scaffold of bone tissue engineering	629:674	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	3	38	theme	composite	572:580	arg1	material					582:589	a porous composite material	563:589	a porous composite material made of silk fibroin and cellulose	563:624	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	2	39	theme	bone	458:461	arg1	in-growth					463:471	bone in-growth	458:471	bone in-growth	458:471	The scaffold should mimic natural bone, it should have appropriate mechanical strength, support cell differentiation to the osteogenic lineage, and offer adequate porosity to allow vascularization and bone in-growth.
33153040	4	40	theme	NaCl	801:804	arg1	powder					806:811	NaCl powder	801:811	NaCl powder	801:811	Silk fibroin and cellulose are both dissolved together in N,N-dimethylacetamide/LiCl and molded to a porous structure using NaCl powder.
33153040	5	41	from	matrix	1082:1087	arg1	embedded					1055:1062	embedded	1055:1062	embedded	1055:1062	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	0	42	theme	Tissue	49:54	arg1	Engineering					56:66	Bone Tissue Engineering	44:66	Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching	44:149	Porous Silk Fibroin/Cellulose Hydrogels for Bone Tissue Engineering via a Novel Combined Process Based on Sequential Regeneration and Porogen Leaching.
33153040	6	43	theme	porous	1167:1172	arg1	structure					1174:1182	a porous structure	1165:1182	a porous structure	1165:1182	Finally, the hydrogels are soaked in water to dissolve the NaCl for making a porous structure.
33153040	3	44	theme	engineering	664:674	arg1	scaffold					640:647	a suitable scaffold	629:647	a suitable scaffold of bone tissue engineering	629:674	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	3	44	theme	engineering	664:674	arg1	material					582:589	a porous composite material	563:589	a porous composite material made of silk fibroin and cellulose	563:624	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	9	45	theme	tissue	1529:1534	arg1	engineering					1536:1546	bone tissue engineering	1524:1546	bone tissue engineering	1524:1546	The hydrogels support the differentiation of MC3T3 cells to osteoblasts and are expected to be a good scaffold for bone tissue engineering.
33153040	2	46	theme	mechanical	324:333	arg1	strength					335:342	appropriate mechanical strength	312:342	appropriate mechanical strength	312:342	The scaffold should mimic natural bone, it should have appropriate mechanical strength, support cell differentiation to the osteogenic lineage, and offer adequate porosity to allow vascularization and bone in-growth.
33153040	9	47	theme	bone	1524:1527	arg1	engineering					1536:1546	bone tissue engineering	1524:1546	bone tissue engineering	1524:1546	The hydrogels support the differentiation of MC3T3 cells to osteoblasts and are expected to be a good scaffold for bone tissue engineering.
33153040	7	48	theme	fibroin	1302:1308	arg1	material					1318:1325	the silk fibroin control material	1293:1325	the silk fibroin control material	1293:1325	The cellulose composition results in improving the mechanical properties for the hydrogels in comparison to the silk fibroin control material.
33153040	4	49	theme	porous	778:783	arg1	structure					785:793	a porous structure	776:793	a porous structure using NaCl powder	776:811	Silk fibroin and cellulose are both dissolved together in N,N-dimethylacetamide/LiCl and molded to a porous structure using NaCl powder.
33153040	2	50	theme	appropriate	312:322	arg1	strength					335:342	appropriate mechanical strength	312:342	appropriate mechanical strength	312:342	The scaffold should mimic natural bone, it should have appropriate mechanical strength, support cell differentiation to the osteogenic lineage, and offer adequate porosity to allow vascularization and bone in-growth.
33153040	5	51	theme	silk	949:952	arg1	fibroin					954:960	the remaining silk fibroin	935:960	the remaining silk fibroin in the hydrogel	935:976	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	1	52	contain	have	203:206	arg2	variety					210:216	a variety	208:216	a variety of features	208:228	Scaffolds used for bone tissue engineering need to have a variety of features to accommodate bone cells.
33153040	1	52	contain	have	203:206	arg1	Scaffolds					152:160	Scaffolds	152:160	Scaffolds used for bone tissue engineering	152:193	Scaffolds used for bone tissue engineering need to have a variety of features to accommodate bone cells.
33153040	1	52	contain	have	203:206	arg2	features					221:228	features	221:228	features	221:228	Scaffolds used for bone tissue engineering need to have a variety of features to accommodate bone cells.
33153040	3	53	theme	silk	599:602	arg1	fibroin					604:610	silk fibroin	599:610	silk fibroin	599:610	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	7	54	from	hydrogels	1266:1274	arg1	comparison					1279:1288	comparison	1279:1288	comparison to the silk fibroin control material	1279:1325	The cellulose composition results in improving the mechanical properties for the hydrogels in comparison to the silk fibroin control material.
33153040	5	55	theme	regeneration	857:868	arg1	process					870:876	a sequential regeneration process	844:876	a sequential regeneration process	844:876	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	1	56	theme	features	221:228	arg1	features					221:228	features	221:228	features	221:228	Scaffolds used for bone tissue engineering need to have a variety of features to accommodate bone cells.
33153040	1	56	theme	features	221:228	arg1	variety					210:216	a variety	208:216	a variety of features	208:228	Scaffolds used for bone tissue engineering need to have a variety of features to accommodate bone cells.
33153040	3	57	theme	suitable	631:638	arg1	scaffold					640:647	a suitable scaffold	629:647	a suitable scaffold of bone tissue engineering	629:674	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	3	57	theme	suitable	631:638	arg1	material					582:589	a porous composite material	563:589	a porous composite material made of silk fibroin and cellulose	563:624	In this work, we aim at developing a new process to fabricate such materials by creating a porous composite material made of silk fibroin and cellulose as a suitable scaffold of bone tissue engineering.
33153040	5	58	theme	sequential	846:855	arg1	process					870:876	a sequential regeneration process	844:876	a sequential regeneration process	844:876	The hydrogels are prepared by a sequential regeneration process: cellulose is solidified by water vapor treatment, while the remaining silk fibroin in the hydrogel is insolubilized by methanol, which leads to a cellulose framework structure embedded in a silk fibroin matrix.
33153040	2	59	theme	osteogenic	381:390	arg1	lineage					392:398	the osteogenic lineage	377:398	the osteogenic lineage	377:398	The scaffold should mimic natural bone, it should have appropriate mechanical strength, support cell differentiation to the osteogenic lineage, and offer adequate porosity to allow vascularization and bone in-growth.
33153040	2	60	contain	have	307:310	arg2	strength					335:342	appropriate mechanical strength	312:342	appropriate mechanical strength	312:342	The scaffold should mimic natural bone, it should have appropriate mechanical strength, support cell differentiation to the osteogenic lineage, and offer adequate porosity to allow vascularization and bone in-growth.
33153040	2	60	contain	have	307:310	arg1	it					297:298	it	297:298	it	297:298	The scaffold should mimic natural bone, it should have appropriate mechanical strength, support cell differentiation to the osteogenic lineage, and offer adequate porosity to allow vascularization and bone in-growth.
33153040	7	61	theme	silk	1297:1300	arg1	material					1318:1325	the silk fibroin control material	1293:1325	the silk fibroin control material	1293:1325	The cellulose composition results in improving the mechanical properties for the hydrogels in comparison to the silk fibroin control material.
33153040	2	62	theme	cell	353:356	arg1	differentiation					358:372	cell differentiation	353:372	cell differentiation to the osteogenic lineage	353:398	The scaffold should mimic natural bone, it should have appropriate mechanical strength, support cell differentiation to the osteogenic lineage, and offer adequate porosity to allow vascularization and bone in-growth.
33910728	4	0	from	count	849:853	arg1	count					890:894	an initial count	879:894	an initial count of 7.8 log CFU/mL	879:912	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	4	1	theme	final	843:847	arg1	count					849:853	a final count	841:853	a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL	841:942	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	1	2	theme	angled	205:210	arg1	electrospinning					224:238	angled dual-nozzle electrospinning	205:238	angled dual-nozzle electrospinning	205:238	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	0	3	theme	acetate	93:99	arg1	fibers					108:113	poly(vinyl alcohol)/cellulose acetate hybrid fibers	63:113	poly(vinyl alcohol)/cellulose acetate hybrid fibers	63:113	Improved digestive stability of probiotics encapsulated within poly(vinyl alcohol)/cellulose acetate hybrid fibers.
33910728	1	4	theme	gastrointestinal	304:319	arg1	stability					321:329	their gastrointestinal stability	298:329	their gastrointestinal stability	298:329	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	2	5	theme	toxic	550:554	arg1	solvent					556:562	the toxic solvent	546:562	the toxic solvent	546:562	In this study, Escherichia coli strain Nissle 1917 (EcN) cells were encapsulated within PVA/CA composite mats, where CA enhanced the bacterial stability under gastric conditions and PVA provided protection against the toxic solvent during the electrospinning process.
33910728	4	6	theme	free	745:748	arg1	cells					750:754	free cells	745:754	free cells	745:754	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	1	7	theme	dual-nozzle	212:222	arg1	electrospinning					224:238	angled dual-nozzle electrospinning	205:238	angled dual-nozzle electrospinning	205:238	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	0	8	theme	/cellulose	82:91	arg1	fibers					108:113	poly(vinyl alcohol)/cellulose acetate hybrid fibers	63:113	poly(vinyl alcohol)/cellulose acetate hybrid fibers	63:113	Improved digestive stability of probiotics encapsulated within poly(vinyl alcohol)/cellulose acetate hybrid fibers.
33910728	5	9	theme	encapsulated	1025:1036	arg1	cells					1038:1042	the encapsulated cells	1021:1042	the encapsulated cells	1021:1042	Considering the enhanced viability of the encapsulated cells in the gastrointestinal system, multi-nozzle electrospinning is a promising technique for the fabrication of novel matrices for probiotic encapsulation.
33910728	5	10	theme	promising	1110:1118	arg1	electrospinning					1089:1103	multi-nozzle electrospinning	1076:1103	multi-nozzle electrospinning	1076:1103	Considering the enhanced viability of the encapsulated cells in the gastrointestinal system, multi-nozzle electrospinning is a promising technique for the fabrication of novel matrices for probiotic encapsulation.
33910728	5	10	theme	promising	1110:1118	arg1	technique					1120:1128	a promising technique	1108:1128	a promising technique for the fabrication of novel matrices for probiotic encapsulation	1108:1194	Considering the enhanced viability of the encapsulated cells in the gastrointestinal system, multi-nozzle electrospinning is a promising technique for the fabrication of novel matrices for probiotic encapsulation.
33910728	1	11	used	used	246:249	arg2	fibers					182:187	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers	116:187	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers	116:187	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	1	12	theme	poly	149:152	arg1	fibers					182:187	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers	116:187	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers	116:187	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	0	13	theme	hybrid	101:106	arg1	fibers					108:113	poly(vinyl alcohol)/cellulose acetate hybrid fibers	63:113	poly(vinyl alcohol)/cellulose acetate hybrid fibers	63:113	Improved digestive stability of probiotics encapsulated within poly(vinyl alcohol)/cellulose acetate hybrid fibers.
33910728	3	14	theme	hybrid	695:700	arg1	fibers					702:707	the hybrid fibers	691:707	the hybrid fibers	691:707	Scanning electron microscopy images revealed that EcN was successfully encapsulated within the hybrid fibers.
33910728	4	15	theme	log	933:935	arg1	CFU/mL					937:942	1 log CFU/mL	931:942	1 log CFU/mL	931:942	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	5	16	theme	probiotic	1172:1180	arg1	encapsulation					1182:1194	probiotic encapsulation	1172:1194	probiotic encapsulation	1172:1194	Considering the enhanced viability of the encapsulated cells in the gastrointestinal system, multi-nozzle electrospinning is a promising technique for the fabrication of novel matrices for probiotic encapsulation.
33910728	2	17	theme	Escherichia	347:357	arg1	cells					389:393	Escherichia coli strain Nissle 1917 (EcN) cells	347:393	Escherichia coli strain Nissle 1917 (EcN) cells	347:393	In this study, Escherichia coli strain Nissle 1917 (EcN) cells were encapsulated within PVA/CA composite mats, where CA enhanced the bacterial stability under gastric conditions and PVA provided protection against the toxic solvent during the electrospinning process.
33910728	0	18	theme	digestive	9:17	arg1	stability					19:27	Improved digestive stability	0:27	Improved digestive stability of probiotics	0:41	Improved digestive stability of probiotics encapsulated within poly(vinyl alcohol)/cellulose acetate hybrid fibers.
33910728	2	19	theme	electrospinning	575:589	arg1	process					591:597	the electrospinning process	571:597	the electrospinning process	571:597	In this study, Escherichia coli strain Nissle 1917 (EcN) cells were encapsulated within PVA/CA composite mats, where CA enhanced the bacterial stability under gastric conditions and PVA provided protection against the toxic solvent during the electrospinning process.
33910728	4	20	theme	simulated	717:725	arg1	system					737:742	the simulated digestive system	713:742	the simulated digestive system	713:742	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	5	21	theme	cells	1038:1042	arg1	viability					1008:1016	the enhanced viability	995:1016	the enhanced viability of the encapsulated cells	995:1042	Considering the enhanced viability of the encapsulated cells in the gastrointestinal system, multi-nozzle electrospinning is a promising technique for the fabrication of novel matrices for probiotic encapsulation.
33910728	1	22	theme	vinyl	154:158	arg1	poly					149:152	poly	149:152	poly(vinyl alcohol)	149:167	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	1	22	theme	vinyl	154:158	arg1	alcohol					160:166	vinyl alcohol	154:166	vinyl alcohol	154:166	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	0	23	theme	Improved	0:7	arg1	stability					19:27	Improved digestive stability	0:27	Improved digestive stability of probiotics	0:41	Improved digestive stability of probiotics encapsulated within poly(vinyl alcohol)/cellulose acetate hybrid fibers.
33910728	4	24	theme	PVA/PVA	967:973	arg1	fibers					975:980	PVA/PVA fibers	967:980	PVA/PVA fibers	967:980	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	4	25	theme	initial	882:888	arg1	count					890:894	an initial count	879:894	an initial count of 7.8 log CFU/mL	879:912	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	2	26	theme	EcN	384:386	arg1	cells					389:393	Escherichia coli strain Nissle 1917 (EcN) cells	347:393	Escherichia coli strain Nissle 1917 (EcN) cells	347:393	In this study, Escherichia coli strain Nissle 1917 (EcN) cells were encapsulated within PVA/CA composite mats, where CA enhanced the bacterial stability under gastric conditions and PVA provided protection against the toxic solvent during the electrospinning process.
33910728	5	27	theme	enhanced	999:1006	arg1	viability					1008:1016	the enhanced viability	995:1016	the enhanced viability of the encapsulated cells	995:1042	Considering the enhanced viability of the encapsulated cells in the gastrointestinal system, multi-nozzle electrospinning is a promising technique for the fabrication of novel matrices for probiotic encapsulation.
33910728	4	28	theme	digestive	727:735	arg1	system					737:742	the simulated digestive system	713:742	the simulated digestive system	713:742	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	2	29	theme	composite	427:435	arg1	mats					437:440	PVA/CA composite mats	420:440	PVA/CA composite mats	420:440	In this study, Escherichia coli strain Nissle 1917 (EcN) cells were encapsulated within PVA/CA composite mats, where CA enhanced the bacterial stability under gastric conditions and PVA provided protection against the toxic solvent during the electrospinning process.
33910728	5	30	theme	novel	1153:1157	arg1	matrices					1159:1166	novel matrices	1153:1166	novel matrices for probiotic encapsulation	1153:1194	Considering the enhanced viability of the encapsulated cells in the gastrointestinal system, multi-nozzle electrospinning is a promising technique for the fabrication of novel matrices for probiotic encapsulation.
33910728	2	31	theme	gastric	491:497	arg1	conditions					499:508	gastric conditions	491:508	gastric conditions	491:508	In this study, Escherichia coli strain Nissle 1917 (EcN) cells were encapsulated within PVA/CA composite mats, where CA enhanced the bacterial stability under gastric conditions and PVA provided protection against the toxic solvent during the electrospinning process.
33910728	4	32	from	count	890:894	arg1	count					849:853	a final count	841:853	a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL	841:942	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	4	32	from	count	890:894	arg1	increase					919:926	an increase	916:926	an increase of 1 log CFU/mL	916:942	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	4	32	from	count	890:894	arg1	CFU/mL					866:871	3.9 log CFU/mL	858:871	3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL)	858:913	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	2	33	theme	Nissle	371:376	arg1	cells					389:393	Escherichia coli strain Nissle 1917 (EcN) cells	347:393	Escherichia coli strain Nissle 1917 (EcN) cells	347:393	In this study, Escherichia coli strain Nissle 1917 (EcN) cells were encapsulated within PVA/CA composite mats, where CA enhanced the bacterial stability under gastric conditions and PVA provided protection against the toxic solvent during the electrospinning process.
33910728	0	34	theme	probiotics	32:41	arg1	stability					19:27	Improved digestive stability	0:27	Improved digestive stability of probiotics	0:41	Improved digestive stability of probiotics encapsulated within poly(vinyl alcohol)/cellulose acetate hybrid fibers.
33910728	2	35	theme	PVA/CA	420:425	arg1	mats					437:440	PVA/CA composite mats	420:440	PVA/CA composite mats	420:440	In this study, Escherichia coli strain Nissle 1917 (EcN) cells were encapsulated within PVA/CA composite mats, where CA enhanced the bacterial stability under gastric conditions and PVA provided protection against the toxic solvent during the electrospinning process.
33910728	3	36	theme	Scanning	600:607	arg1	microscopy					618:627	Scanning electron microscopy	600:627	Scanning electron microscopy images	600:634	Scanning electron microscopy images revealed that EcN was successfully encapsulated within the hybrid fibers.
33910728	2	37	theme	strain	364:369	arg1	cells					389:393	Escherichia coli strain Nissle 1917 (EcN) cells	347:393	Escherichia coli strain Nissle 1917 (EcN) cells	347:393	In this study, Escherichia coli strain Nissle 1917 (EcN) cells were encapsulated within PVA/CA composite mats, where CA enhanced the bacterial stability under gastric conditions and PVA provided protection against the toxic solvent during the electrospinning process.
33910728	0	38	theme	poly	63:66	arg1	fibers					108:113	poly(vinyl alcohol)/cellulose acetate hybrid fibers	63:113	poly(vinyl alcohol)/cellulose acetate hybrid fibers	63:113	Improved digestive stability of probiotics encapsulated within poly(vinyl alcohol)/cellulose acetate hybrid fibers.
33910728	4	39	theme	log	903:905	arg1	CFU/mL					907:912	7.8 log CFU/mL	899:912	7.8 log CFU/mL	899:912	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	4	40	theme	CFU/mL	866:871	arg1	count					849:853	a final count	841:853	a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL	841:942	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	3	41	theme	electron	609:616	arg1	microscopy					618:627	Scanning electron microscopy	600:627	Scanning electron microscopy images	600:634	Scanning electron microscopy images revealed that EcN was successfully encapsulated within the hybrid fibers.
33910728	4	42	theme	PVA/CA-encapsulated	801:819	arg1	cells					821:825	PVA/CA-encapsulated cells	801:825	PVA/CA-encapsulated cells	801:825	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	4	43	theme	CFU/mL	937:942	arg1	increase					919:926	an increase	916:926	an increase of 1 log CFU/mL	916:942	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	4	43	theme	CFU/mL	937:942	arg1	CFU/mL					866:871	3.9 log CFU/mL	858:871	3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL)	858:913	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	4	44	theme	log	862:864	arg1	increase					919:926	an increase	916:926	an increase of 1 log CFU/mL	916:942	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	4	44	theme	log	862:864	arg1	CFU/mL					866:871	3.9 log CFU/mL	858:871	3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL)	858:913	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	1	45	theme	Novel	116:120	arg1	CA					141:142	CA	141:142	CA	141:142	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	1	45	theme	Novel	116:120	arg1	acetate					132:138	Novel cellulose acetate	116:138	Novel cellulose acetate (CA)	116:143	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	1	45	theme	Novel	116:120	arg1	PVA					170:172	PVA	170:172	PVA	170:172	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	1	46	theme	probiotics	276:285	arg1	encapsulation					259:271	the encapsulation	255:271	the encapsulation of probiotics	255:285	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	1	47	theme	cellulose	122:130	arg1	CA					141:142	CA	141:142	CA	141:142	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	1	47	theme	cellulose	122:130	arg1	acetate					132:138	Novel cellulose acetate	116:138	Novel cellulose acetate (CA)	116:143	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	1	47	theme	cellulose	122:130	arg1	PVA					170:172	PVA	170:172	PVA	170:172	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	1	48	theme	hybrid	175:180	arg1	fibers					182:187	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers	116:187	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers	116:187	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	1	49	theme	acetate	132:138	arg1	fibers					182:187	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers	116:187	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers	116:187	Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers, fabricated via angled dual-nozzle electrospinning, were used for the encapsulation of probiotics to enhance their gastrointestinal stability.
33910728	0	50	theme	vinyl	68:72	arg1	alcohol					74:80	vinyl alcohol	68:80	vinyl alcohol	68:80	Improved digestive stability of probiotics encapsulated within poly(vinyl alcohol)/cellulose acetate hybrid fibers.
33910728	0	50	theme	vinyl	68:72	arg1	poly					63:66	poly	63:66	poly(vinyl alcohol)/cellulose acetate hybrid fibers	63:113	Improved digestive stability of probiotics encapsulated within poly(vinyl alcohol)/cellulose acetate hybrid fibers.
33910728	5	51	theme	multi-nozzle	1076:1087	arg1	electrospinning					1089:1103	multi-nozzle electrospinning	1076:1103	multi-nozzle electrospinning	1076:1103	Considering the enhanced viability of the encapsulated cells in the gastrointestinal system, multi-nozzle electrospinning is a promising technique for the fabrication of novel matrices for probiotic encapsulation.
33910728	5	51	theme	multi-nozzle	1076:1087	arg1	technique					1120:1128	a promising technique	1108:1128	a promising technique for the fabrication of novel matrices for probiotic encapsulation	1108:1194	Considering the enhanced viability of the encapsulated cells in the gastrointestinal system, multi-nozzle electrospinning is a promising technique for the fabrication of novel matrices for probiotic encapsulation.
33910728	3	52	dep	microscopy	618:627	arg1	images					629:634	images	629:634	images	629:634	Scanning electron microscopy images revealed that EcN was successfully encapsulated within the hybrid fibers.
33910728	5	53	theme	matrices	1159:1166	arg1	fabrication					1138:1148	the fabrication	1134:1148	the fabrication of novel matrices for probiotic encapsulation	1134:1194	Considering the enhanced viability of the encapsulated cells in the gastrointestinal system, multi-nozzle electrospinning is a promising technique for the fabrication of novel matrices for probiotic encapsulation.
33910728	5	54	theme	gastrointestinal	1051:1066	arg1	system					1068:1073	the gastrointestinal system	1047:1073	the gastrointestinal system	1047:1073	Considering the enhanced viability of the encapsulated cells in the gastrointestinal system, multi-nozzle electrospinning is a promising technique for the fabrication of novel matrices for probiotic encapsulation.
33910728	2	55	dep	Escherichia	347:357	arg1	coli					359:362	coli	359:362	coli	359:362	In this study, Escherichia coli strain Nissle 1917 (EcN) cells were encapsulated within PVA/CA composite mats, where CA enhanced the bacterial stability under gastric conditions and PVA provided protection against the toxic solvent during the electrospinning process.
33910728	4	56	theme	CFU/mL	907:912	arg1	count					890:894	an initial count	879:894	an initial count of 7.8 log CFU/mL	879:912	In the simulated digestive system, free cells lost their viability within 100 min, whereas PVA/CA-encapsulated cells survived with a final count of 3.9 log CFU/mL (from an initial count of 7.8 log CFU/mL), an increase of 1 log CFU/mL compared with those in PVA/PVA fibers.
33910728	2	57	theme	bacterial	465:473	arg1	stability					475:483	the bacterial stability	461:483	the bacterial stability	461:483	In this study, Escherichia coli strain Nissle 1917 (EcN) cells were encapsulated within PVA/CA composite mats, where CA enhanced the bacterial stability under gastric conditions and PVA provided protection against the toxic solvent during the electrospinning process.
33112612	4	0	theme	spiral	468:473	arg1	microstructure					485:498	a highly organized spiral honeycomb microstructure	449:498	a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3)	449:588	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	7	1	theme	simple	960:965	arg1	process					992:998	This simple self-assembly production process	955:998	This simple self-assembly production process	955:998	This simple self-assembly production process is highly scalable, does not require any toxic chemicals, and enables the fabrication of light, strong, and tough hierarchical composite materials with tunable shape and size.
33112612	1	2	theme	high	147:150	arg1	strength					152:159	high strength	147:159	high strength	147:159	Natural materials, such as nacre and silk, exhibit both high strength and toughness due to their hierarchical structures highly organized at the nano-, micro-, and macroscales.
33112612	7	3	theme	strong	1096:1101	arg1	materials					1137:1145	light, strong, and tough hierarchical composite materials	1089:1145	light, strong, and tough hierarchical composite materials	1089:1145	This simple self-assembly production process is highly scalable, does not require any toxic chemicals, and enables the fabrication of light, strong, and tough hierarchical composite materials with tunable shape and size.
33112612	6	4	theme	fabrication	794:804	arg1	process					806:812	The mild fabrication process	785:812	The mild fabrication process	785:812	The mild fabrication process consists of an in situ fermentation step utilizing poly(vinyl alcohol), followed by a post-treatment including freezing-thawing and boiling.
33112612	6	5	theme	mild	789:792	arg1	process					806:812	The mild fabrication process	785:812	The mild fabrication process	785:812	The mild fabrication process consists of an in situ fermentation step utilizing poly(vinyl alcohol), followed by a post-treatment including freezing-thawing and boiling.
33112612	5	6	theme	finite-element	678:691	arg1	simulations					693:703	finite-element simulations	678:703	finite-element simulations	678:703	Both experiments and finite-element simulations indicate improved mechanical properties resulting from the honeycomb structure.
33112612	6	7	theme	vinyl	870:874	arg1	poly					865:868	poly	865:868	poly(vinyl alcohol)	865:883	The mild fabrication process consists of an in situ fermentation step utilizing poly(vinyl alcohol), followed by a post-treatment including freezing-thawing and boiling.
33112612	6	7	theme	vinyl	870:874	arg1	alcohol					876:882	vinyl alcohol	870:882	vinyl alcohol	870:882	The mild fabrication process consists of an in situ fermentation step utilizing poly(vinyl alcohol), followed by a post-treatment including freezing-thawing and boiling.
33112612	7	8	theme	light	1089:1093	arg1	materials					1137:1145	light, strong, and tough hierarchical composite materials	1089:1145	light, strong, and tough hierarchical composite materials	1089:1145	This simple self-assembly production process is highly scalable, does not require any toxic chemicals, and enables the fabrication of light, strong, and tough hierarchical composite materials with tunable shape and size.
33112612	2	9	theme	Bacterial	268:276	arg1	BC					289:290	BC	289:290	BC	289:290	Bacterial cellulose (BC) presents a hierarchical fibril structure at the nanoscale.
33112612	2	9	theme	Bacterial	268:276	arg1	cellulose					278:286	Bacterial cellulose	268:286	Bacterial cellulose (BC)	268:291	Bacterial cellulose (BC) presents a hierarchical fibril structure at the nanoscale.
33112612	4	10	theme	organized	458:466	arg1	microstructure					485:498	a highly organized spiral honeycomb microstructure	449:498	a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3)	449:588	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	1	11	theme	Natural	91:97	arg1	silk					128:131	silk	128:131	silk	128:131	Natural materials, such as nacre and silk, exhibit both high strength and toughness due to their hierarchical structures highly organized at the nano-, micro-, and macroscales.
33112612	1	11	theme	Natural	91:97	arg1	nacre					118:122	nacre	118:122	nacre	118:122	Natural materials, such as nacre and silk, exhibit both high strength and toughness due to their hierarchical structures highly organized at the nano-, micro-, and macroscales.
33112612	1	11	theme	Natural	91:97	arg1	materials					99:107	Natural materials	91:107	Natural materials	91:107	Natural materials, such as nacre and silk, exhibit both high strength and toughness due to their hierarchical structures highly organized at the nano-, micro-, and macroscales.
33112612	1	12	theme	due	175:177	arg1	strength					152:159	high strength	147:159	high strength	147:159	Natural materials, such as nacre and silk, exhibit both high strength and toughness due to their hierarchical structures highly organized at the nano-, micro-, and macroscales.
33112612	0	13	theme	Spiral	0:5	arg1	Honeycomb					7:15	Spiral Honeycomb	0:15	Spiral Honeycomb	0:15	Spiral Honeycomb Microstructured Bacterial Cellulose for Increased Strength and Toughness.
33112612	6	14	dep	consists	814:821	arg1	followed					886:893	followed	886:893	followed by a post-treatment including freezing-thawing and boiling	886:952	The mild fabrication process consists of an in situ fermentation step utilizing poly(vinyl alcohol), followed by a post-treatment including freezing-thawing and boiling.
33112612	4	15	theme	pull-out	596:603	arg1	morphologies					619:630	pull-out and de-spiral morphologies	596:630	pull-out and de-spiral morphologies observed during failure	596:654	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	0	16	theme	Bacterial	33:41	arg1	Cellulose					43:51	Bacterial Cellulose	33:51	Bacterial Cellulose for Increased Strength and Toughness	33:88	Spiral Honeycomb Microstructured Bacterial Cellulose for Increased Strength and Toughness.
33112612	4	17	theme	tensile	522:528	arg1	strength					530:537	a high tensile strength	515:537	a high tensile strength (315 MPa)	515:547	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	4	17	theme	tensile	522:528	arg1	MPa					544:546	315 MPa	540:546	315 MPa	540:546	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	2	18	from	nanoscale	341:349	arg1	structure					324:332	a hierarchical fibril structure	302:332	a hierarchical fibril structure at the nanoscale	302:349	Bacterial cellulose (BC) presents a hierarchical fibril structure at the nanoscale.
33112612	4	19	theme	MJ	582:583	arg1	m-3					585:587	17.8 MJ m-3	577:587	17.8 MJ m-3	577:587	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	4	19	theme	MJ	582:583	arg1	value					570:574	a high toughness value	553:574	a high toughness value (17.8 MJ m-3)	553:588	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	7	20	theme	materials	1137:1145	arg1	fabrication					1074:1084	the fabrication	1070:1084	the fabrication of light, strong, and tough hierarchical composite materials with tunable shape and size	1070:1173	This simple self-assembly production process is highly scalable, does not require any toxic chemicals, and enables the fabrication of light, strong, and tough hierarchical composite materials with tunable shape and size.
33112612	1	21	theme	hierarchical	188:199	arg1	structures					201:210	their hierarchical structures	182:210	their hierarchical structures highly organized at the nano-, micro-, and macroscales	182:265	Natural materials, such as nacre and silk, exhibit both high strength and toughness due to their hierarchical structures highly organized at the nano-, micro-, and macroscales.
33112612	3	22	theme	BC	380:381	arg1	nanofibers					383:392	BC nanofibers	380:392	BC nanofibers	380:392	At the microscale, however, BC nanofibers are distributed randomly.
33112612	6	23	theme	fermentation	837:848	arg1	step					850:853	an in situ fermentation step	826:853	an in situ fermentation step utilizing poly(vinyl alcohol)	826:883	The mild fabrication process consists of an in situ fermentation step utilizing poly(vinyl alcohol), followed by a post-treatment including freezing-thawing and boiling.
33112612	7	24	theme	hierarchical	1114:1125	arg1	materials					1137:1145	light, strong, and tough hierarchical composite materials	1089:1145	light, strong, and tough hierarchical composite materials	1089:1145	This simple self-assembly production process is highly scalable, does not require any toxic chemicals, and enables the fabrication of light, strong, and tough hierarchical composite materials with tunable shape and size.
33112612	7	25	theme	toxic	1041:1045	arg1	chemicals					1047:1055	any toxic chemicals	1037:1055	any toxic chemicals	1037:1055	This simple self-assembly production process is highly scalable, does not require any toxic chemicals, and enables the fabrication of light, strong, and tough hierarchical composite materials with tunable shape and size.
33112612	7	26	theme	composite	1127:1135	arg1	materials					1137:1145	light, strong, and tough hierarchical composite materials	1089:1145	light, strong, and tough hierarchical composite materials	1089:1145	This simple self-assembly production process is highly scalable, does not require any toxic chemicals, and enables the fabrication of light, strong, and tough hierarchical composite materials with tunable shape and size.
33112612	5	27	theme	honeycomb	764:772	arg1	structure					774:782	the honeycomb structure	760:782	the honeycomb structure	760:782	Both experiments and finite-element simulations indicate improved mechanical properties resulting from the honeycomb structure.
33112612	6	28	dep	in	829:830	arg1	situ					832:835	situ	832:835	situ	832:835	The mild fabrication process consists of an in situ fermentation step utilizing poly(vinyl alcohol), followed by a post-treatment including freezing-thawing and boiling.
33112612	6	29	theme	in	829:830	arg1	step					850:853	an in situ fermentation step	826:853	an in situ fermentation step utilizing poly(vinyl alcohol)	826:883	The mild fabrication process consists of an in situ fermentation step utilizing poly(vinyl alcohol), followed by a post-treatment including freezing-thawing and boiling.
33112612	0	30	theme	Increased	57:65	arg1	Strength					67:74	Strength	67:74	Strength	67:74	Spiral Honeycomb Microstructured Bacterial Cellulose for Increased Strength and Toughness.
33112612	4	31	theme	high	517:520	arg1	strength					530:537	a high tensile strength	515:537	a high tensile strength (315 MPa)	515:547	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	4	31	theme	high	517:520	arg1	MPa					544:546	315 MPa	540:546	315 MPa	540:546	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	2	32	theme	fibril	317:322	arg1	structure					324:332	a hierarchical fibril structure	302:332	a hierarchical fibril structure at the nanoscale	302:349	Bacterial cellulose (BC) presents a hierarchical fibril structure at the nanoscale.
33112612	2	33	theme	hierarchical	304:315	arg1	structure					324:332	a hierarchical fibril structure	302:332	a hierarchical fibril structure at the nanoscale	302:349	Bacterial cellulose (BC) presents a hierarchical fibril structure at the nanoscale.
33112612	4	34	theme	toughness	560:568	arg1	m-3					585:587	17.8 MJ m-3	577:587	17.8 MJ m-3	577:587	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	4	34	theme	toughness	560:568	arg1	value					570:574	a high toughness value	553:574	a high toughness value (17.8 MJ m-3)	553:588	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	7	35	theme	self-assembly	967:979	arg1	process					992:998	This simple self-assembly production process	955:998	This simple self-assembly production process	955:998	This simple self-assembly production process is highly scalable, does not require any toxic chemicals, and enables the fabrication of light, strong, and tough hierarchical composite materials with tunable shape and size.
33112612	7	36	with	fabrication	1074:1084	arg1	size					1170:1173	size	1170:1173	size	1170:1173	This simple self-assembly production process is highly scalable, does not require any toxic chemicals, and enables the fabrication of light, strong, and tough hierarchical composite materials with tunable shape and size.
33112612	7	36	with	fabrication	1074:1084	arg1	shape					1160:1164	tunable shape	1152:1164	tunable shape	1152:1164	This simple self-assembly production process is highly scalable, does not require any toxic chemicals, and enables the fabrication of light, strong, and tough hierarchical composite materials with tunable shape and size.
33112612	4	37	theme	high	555:558	arg1	m-3					585:587	17.8 MJ m-3	577:587	17.8 MJ m-3	577:587	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	4	37	theme	high	555:558	arg1	value					570:574	a high toughness value	553:574	a high toughness value (17.8 MJ m-3)	553:588	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	5	38	theme	improved	714:721	arg1	properties					734:743	improved mechanical properties	714:743	improved mechanical properties resulting from the honeycomb structure	714:782	Both experiments and finite-element simulations indicate improved mechanical properties resulting from the honeycomb structure.
33112612	7	39	theme	production	981:990	arg1	process					992:998	This simple self-assembly production process	955:998	This simple self-assembly production process	955:998	This simple self-assembly production process is highly scalable, does not require any toxic chemicals, and enables the fabrication of light, strong, and tough hierarchical composite materials with tunable shape and size.
33112612	5	40	theme	mechanical	723:732	arg1	properties					734:743	improved mechanical properties	714:743	improved mechanical properties resulting from the honeycomb structure	714:782	Both experiments and finite-element simulations indicate improved mechanical properties resulting from the honeycomb structure.
33112612	4	41	theme	honeycomb	475:483	arg1	microstructure					485:498	a highly organized spiral honeycomb microstructure	449:498	a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3)	449:588	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	4	42	theme	de-spiral	609:617	arg1	morphologies					619:630	pull-out and de-spiral morphologies	596:630	pull-out and de-spiral morphologies observed during failure	596:654	Here, BC self-assembles into a highly organized spiral honeycomb microstructure giving rise to a high tensile strength (315 MPa) and a high toughness value (17.8 MJ m-3), with pull-out and de-spiral morphologies observed during failure.
33112612	7	43	theme	tunable	1152:1158	arg1	shape					1160:1164	tunable shape	1152:1164	tunable shape	1152:1164	This simple self-assembly production process is highly scalable, does not require any toxic chemicals, and enables the fabrication of light, strong, and tough hierarchical composite materials with tunable shape and size.
31965498	6	0	theme	chitosan-based	745:758	arg1	material					760:767	This chitosan-based material	740:767	This chitosan-based material	740:767	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	6	1	theme	water	974:978	arg1	devices					993:999	water purification devices	974:999	water purification devices	974:999	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	5	2	theme	reuse	684:688	arg1	cycles					674:679	several cycles	666:679	several cycles of reuse with a hydraulic retention time reduction of 1 h	666:737	Additionally, the adsorption capacity of the material, below its saturation, allows several cycles of reuse with a hydraulic retention time reduction of 1 h.
31965498	1	3	theme	copper	193:198	arg1	ions					200:203	copper ions	193:203	copper ions	193:203	This work demonstrates that a biodegradable chitosan-based biocomposite packed in mini-reactors successfully removes copper ions from aqueous solutions.
31965498	6	4	theme	filter	954:959	arg1	component					961:969	a filter component	952:969	wastewater effluents as well as a filter component in water purification devices	920:999	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	6	5	theme	commercial	865:874	arg1	adsorbents					876:885	costly commercial adsorbents	858:885	costly commercial adsorbents	858:885	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	2	6	theme	shrimp	317:322	arg1	wastes					324:329	shrimp wastes	317:329	shrimp wastes	317:329	The chitosan is obtained by deacetylation of biological chitin, which is extracted from shrimp wastes by lactic acid fermentation.
31965498	6	7	theme	costly	858:863	arg1	adsorbents					876:885	costly commercial adsorbents	858:885	costly commercial adsorbents	858:885	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	4	8	theme	ion	516:518	arg1	removal					520:526	The highest copper ion removal	497:526	The highest copper ion removal	497:526	The highest copper ion removal is 62.5 mg Cu2+ per g of the biodegradable adsorbent.
31965498	4	8	theme	ion	516:518	arg1	Cu2+					539:542	62.5 mg Cu2+	531:542	62.5 mg Cu2+ per g of the biodegradable adsorbent	531:579	The highest copper ion removal is 62.5 mg Cu2+ per g of the biodegradable adsorbent.
31965498	1	9	theme	aqueous	210:216	arg1	solutions					218:226	aqueous solutions	210:226	aqueous solutions	210:226	This work demonstrates that a biodegradable chitosan-based biocomposite packed in mini-reactors successfully removes copper ions from aqueous solutions.
31965498	3	10	from	matrix	421:426	arg1	embedded					382:389	embedded	382:389	embedded	382:389	The polysaccharide is embedded in a biodegradable prepolymer matrix before extrusion to produce porous cylindrical pellets of 2 × 80 mm.
31965498	3	10	from	matrix	421:426	arg1	polysaccharide					364:377	The polysaccharide	360:377	The polysaccharide	360:377	The polysaccharide is embedded in a biodegradable prepolymer matrix before extrusion to produce porous cylindrical pellets of 2 × 80 mm.
31965498	6	11	from	ions	912:915	arg1	component					961:969	a filter component	952:969	wastewater effluents as well as a filter component in water purification devices	920:999	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	6	11	from	ions	912:915	arg1	effluents					931:939	wastewater effluents	920:939	wastewater effluents as well as a filter component in water purification devices	920:999	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	3	12	theme	2 × 80 mm	486:494	arg1	pellets					475:481	porous cylindrical pellets	456:481	porous cylindrical pellets of 2 × 80 mm	456:494	The polysaccharide is embedded in a biodegradable prepolymer matrix before extrusion to produce porous cylindrical pellets of 2 × 80 mm.
31965498	5	13	theme	several	666:672	arg1	cycles					674:679	several cycles	666:679	several cycles of reuse with a hydraulic retention time reduction of 1 h	666:737	Additionally, the adsorption capacity of the material, below its saturation, allows several cycles of reuse with a hydraulic retention time reduction of 1 h.
31965498	6	14	theme	non-biodegradable	827:843	arg1	materials					845:853	non-biodegradable materials	827:853	non-biodegradable materials	827:853	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	2	15	theme	acid	341:344	arg1	fermentation					346:357	lactic acid fermentation	334:357	lactic acid fermentation	334:357	The chitosan is obtained by deacetylation of biological chitin, which is extracted from shrimp wastes by lactic acid fermentation.
31965498	3	16	theme	cylindrical	463:473	arg1	pellets					475:481	porous cylindrical pellets	456:481	porous cylindrical pellets of 2 × 80 mm	456:494	The polysaccharide is embedded in a biodegradable prepolymer matrix before extrusion to produce porous cylindrical pellets of 2 × 80 mm.
31965498	0	17	theme	Copper	0:5	arg1	removal					7:13	Copper removal	0:13	Copper removal from wastewater by a chitosan-based biodegradable composite.	0:74	Copper removal from wastewater by a chitosan-based biodegradable composite.
31965498	2	18	theme	lactic	334:339	arg1	fermentation					346:357	lactic acid fermentation	334:357	lactic acid fermentation	334:357	The chitosan is obtained by deacetylation of biological chitin, which is extracted from shrimp wastes by lactic acid fermentation.
31965498	6	19	theme	wastewater	920:929	arg1	effluents					931:939	wastewater effluents	920:939	wastewater effluents as well as a filter component in water purification devices	920:999	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	3	20	theme	biodegradable	396:408	arg1	matrix					421:426	a biodegradable prepolymer matrix	394:426	a biodegradable prepolymer matrix before extrusion to produce porous cylindrical pellets of 2 × 80 mm	394:494	The polysaccharide is embedded in a biodegradable prepolymer matrix before extrusion to produce porous cylindrical pellets of 2 × 80 mm.
31965498	5	21	theme	material	627:634	arg1	capacity					611:618	the adsorption capacity	596:618	the adsorption capacity of the material	596:634	Additionally, the adsorption capacity of the material, below its saturation, allows several cycles of reuse with a hydraulic retention time reduction of 1 h.
31965498	3	22	theme	prepolymer	410:419	arg1	matrix					421:426	a biodegradable prepolymer matrix	394:426	a biodegradable prepolymer matrix before extrusion to produce porous cylindrical pellets of 2 × 80 mm	394:494	The polysaccharide is embedded in a biodegradable prepolymer matrix before extrusion to produce porous cylindrical pellets of 2 × 80 mm.
31965498	5	23	theme	1 h	735:737	arg1	reduction					722:730	a hydraulic retention time reduction	695:730	a hydraulic retention time reduction of 1 h	695:737	Additionally, the adsorption capacity of the material, below its saturation, allows several cycles of reuse with a hydraulic retention time reduction of 1 h.
31965498	1	24	theme	biodegradable	106:118	arg1	biocomposite					135:146	a biodegradable chitosan-based biocomposite	104:146	a biodegradable chitosan-based biocomposite packed in mini-reactors	104:170	This work demonstrates that a biodegradable chitosan-based biocomposite packed in mini-reactors successfully removes copper ions from aqueous solutions.
31965498	3	25	from	embedded	382:389	arg1	matrix					421:426	a biodegradable prepolymer matrix	394:426	a biodegradable prepolymer matrix before extrusion to produce porous cylindrical pellets of 2 × 80 mm	394:494	The polysaccharide is embedded in a biodegradable prepolymer matrix before extrusion to produce porous cylindrical pellets of 2 × 80 mm.
31965498	3	26	theme	porous	456:461	arg1	pellets					475:481	porous cylindrical pellets	456:481	porous cylindrical pellets of 2 × 80 mm	456:494	The polysaccharide is embedded in a biodegradable prepolymer matrix before extrusion to produce porous cylindrical pellets of 2 × 80 mm.
31965498	4	27	theme	copper	509:514	arg1	removal					520:526	The highest copper ion removal	497:526	The highest copper ion removal	497:526	The highest copper ion removal is 62.5 mg Cu2+ per g of the biodegradable adsorbent.
31965498	4	27	theme	copper	509:514	arg1	Cu2+					539:542	62.5 mg Cu2+	531:542	62.5 mg Cu2+ per g of the biodegradable adsorbent	531:579	The highest copper ion removal is 62.5 mg Cu2+ per g of the biodegradable adsorbent.
31965498	6	28	from	effluents	931:939	arg1	devices					993:999	water purification devices	974:999	water purification devices	974:999	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	6	29	theme	other	804:808	arg1	approaches					810:819	other approaches	804:819	other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices	804:999	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	6	30	theme	purification	980:991	arg1	devices					993:999	water purification devices	974:999	water purification devices	974:999	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	0	31	theme	biodegradable	51:63	arg1	composite					65:73	a chitosan-based biodegradable composite	34:73	a chitosan-based biodegradable composite	34:73	Copper removal from wastewater by a chitosan-based biodegradable composite.
31965498	5	32	theme	hydraulic	697:705	arg1	reduction					722:730	a hydraulic retention time reduction	695:730	a hydraulic retention time reduction of 1 h	695:737	Additionally, the adsorption capacity of the material, below its saturation, allows several cycles of reuse with a hydraulic retention time reduction of 1 h.
31965498	4	33	theme	highest	501:507	arg1	removal					520:526	The highest copper ion removal	497:526	The highest copper ion removal	497:526	The highest copper ion removal is 62.5 mg Cu2+ per g of the biodegradable adsorbent.
31965498	4	33	theme	highest	501:507	arg1	Cu2+					539:542	62.5 mg Cu2+	531:542	62.5 mg Cu2+ per g of the biodegradable adsorbent	531:579	The highest copper ion removal is 62.5 mg Cu2+ per g of the biodegradable adsorbent.
31965498	4	34	theme	62.5 mg	531:537	arg1	removal					520:526	The highest copper ion removal	497:526	The highest copper ion removal	497:526	The highest copper ion removal is 62.5 mg Cu2+ per g of the biodegradable adsorbent.
31965498	4	34	theme	62.5 mg	531:537	arg1	Cu2+					539:542	62.5 mg Cu2+	531:542	62.5 mg Cu2+ per g of the biodegradable adsorbent	531:579	The highest copper ion removal is 62.5 mg Cu2+ per g of the biodegradable adsorbent.
31965498	1	35	theme	chitosan-based	120:133	arg1	biocomposite					135:146	a biodegradable chitosan-based biocomposite	104:146	a biodegradable chitosan-based biocomposite packed in mini-reactors	104:170	This work demonstrates that a biodegradable chitosan-based biocomposite packed in mini-reactors successfully removes copper ions from aqueous solutions.
31965498	0	36	theme	chitosan-based	36:49	arg1	composite					65:73	a chitosan-based biodegradable composite	34:73	a chitosan-based biodegradable composite	34:73	Copper removal from wastewater by a chitosan-based biodegradable composite.
31965498	5	37	theme	retention	707:715	arg1	reduction					722:730	a hydraulic retention time reduction	695:730	a hydraulic retention time reduction of 1 h	695:737	Additionally, the adsorption capacity of the material, below its saturation, allows several cycles of reuse with a hydraulic retention time reduction of 1 h.
31965498	6	38	theme	metal	906:910	arg1	ions					912:915	heavy metal ions	900:915	heavy metal ions in wastewater effluents as well as a filter component in water purification devices	900:999	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	5	39	with	cycles	674:679	arg1	reduction					722:730	a hydraulic retention time reduction	695:730	a hydraulic retention time reduction of 1 h	695:737	Additionally, the adsorption capacity of the material, below its saturation, allows several cycles of reuse with a hydraulic retention time reduction of 1 h.
31965498	4	40	theme	adsorbent	571:579	arg1	g					548:548	g	548:548	g of the biodegradable adsorbent	548:579	The highest copper ion removal is 62.5 mg Cu2+ per g of the biodegradable adsorbent.
31965498	5	41	theme	time	717:720	arg1	reduction					722:730	a hydraulic retention time reduction	695:730	a hydraulic retention time reduction of 1 h	695:737	Additionally, the adsorption capacity of the material, below its saturation, allows several cycles of reuse with a hydraulic retention time reduction of 1 h.
31965498	6	42	theme	heavy	900:904	arg1	ions					912:915	heavy metal ions	900:915	heavy metal ions in wastewater effluents as well as a filter component in water purification devices	900:999	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	5	43	theme	adsorption	600:609	arg1	capacity					611:618	the adsorption capacity	596:618	the adsorption capacity of the material	596:634	Additionally, the adsorption capacity of the material, below its saturation, allows several cycles of reuse with a hydraulic retention time reduction of 1 h.
31965498	6	44	from	component	961:969	arg1	devices					993:999	water purification devices	974:999	water purification devices	974:999	This chitosan-based material is advantageous when compared with other approaches using non-biodegradable materials or costly commercial adsorbents for removing heavy metal ions in wastewater effluents as well as a filter component in water purification devices.
31965498	2	45	theme	chitin	285:290	arg1	deacetylation					257:269	deacetylation	257:269	deacetylation of biological chitin, which is extracted from shrimp wastes by lactic acid fermentation	257:357	The chitosan is obtained by deacetylation of biological chitin, which is extracted from shrimp wastes by lactic acid fermentation.
31965498	0	46	from	wastewater	20:29	arg1	removal					7:13	Copper removal	0:13	Copper removal from wastewater by a chitosan-based biodegradable composite.	0:74	Copper removal from wastewater by a chitosan-based biodegradable composite.
31965498	2	47	theme	biological	274:283	arg1	chitin					285:290	biological chitin	274:290	biological chitin	274:290	The chitosan is obtained by deacetylation of biological chitin, which is extracted from shrimp wastes by lactic acid fermentation.
34740857	15	0	theme	flying	1803:1808	arg1	insects					1810:1816	flying insects	1803:1816	flying insects	1803:1816	Our multi-faceted assessment advances our understanding of thorax cuticle structural and material heterogeneity and the potential benefits of material gradation to flying insects.
34740857	5	1	theme	Apis	594:597	arg1	mellifera					599:607	Apis mellifera	594:607	honey bee; Apis mellifera	583:607	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	9	2	theme	fliers	1125:1130	arg1	types					1116:1120	the two types	1108:1120	the two types of fliers	1108:1130	Modulus gradation, but not mean modulus, differed between the two types of fliers.
34740857	10	3	theme	A.	1150:1151	arg1	mellifera					1153:1161	A. mellifera	1150:1161	A. mellifera	1150:1161	In some regions, A. mellifera had a positive linear modulus gradient from cuticle interior to exterior of about 2 GPa.
34740857	18	4	theme	Manduca	2347:2353	arg1	sexta					2355:2359	hawkmoth; Manduca sexta	2337:2359	hawkmoth; Manduca sexta	2337:2359	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	18	4	theme	Manduca	2347:2353	arg1	synchronous					2324:2334	synchronous	2324:2334	synchronous	2324:2334	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	20	5	theme	mobile	2703:2708	arg1	robots					2716:2721	mobile micro robots	2703:2721	mobile micro robots	2703:2721	Understanding material variation in the thorax may inform design of technologies inspired by insects, such as mobile micro robots.
34740857	7	6	with	distribution	843:854	arg1	nanoindentation					927:941	nanoindentation	927:941	nanoindentation	927:941	We investigated cuticle structure using histology, resilin distribution through confocal laser scanning microscopy, and modulus gradation with nanoindentation.
34740857	18	7	theme	hawkmoth	2337:2344	arg1	sexta					2355:2359	hawkmoth; Manduca sexta	2337:2359	hawkmoth; Manduca sexta	2337:2359	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	18	7	theme	hawkmoth	2337:2344	arg1	synchronous					2324:2334	synchronous	2324:2334	synchronous	2324:2334	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	15	8	theme	material	1781:1788	arg1	gradation					1790:1798	material gradation	1781:1798	material gradation to flying insects	1781:1816	Our multi-faceted assessment advances our understanding of thorax cuticle structural and material heterogeneity and the potential benefits of material gradation to flying insects.
34740857	13	9	theme	modulus	1547:1553	arg1	side					1555:1558	the high modulus side	1538:1558	the high modulus side	1538:1558	Stress was reduced when cuticle with a linear gradient was compressed from the high modulus side.
34740857	12	10	theme	finite	1360:1365	arg1	modeling					1375:1382	finite element modeling	1360:1382	finite element modeling	1360:1382	We utilized finite element modeling to assess how measured modulus gradients influenced maximum stress in cuticle.
34740857	3	11	theme	material	279:286	arg1	properties					288:297	material properties	279:297	material properties	279:297	The structure, composition, and material properties of this chitinous structure may influence the efficiency of the thorax in flight.
34740857	11	12	theme	modulus	1265:1271	arg1	values					1273:1278	modulus values	1265:1278	modulus values through cuticle thickness	1265:1304	In M. sexta, modulus values through cuticle thickness were not well represented by linear fits.
34740857	12	13	from	stress	1444:1449	arg1	cuticle					1454:1460	cuticle	1454:1460	cuticle	1454:1460	We utilized finite element modeling to assess how measured modulus gradients influenced maximum stress in cuticle.
34740857	18	14	theme	laser	2145:2149	arg1	microscopy					2160:2169	confocal laser scanning microscopy	2136:2169	confocal laser scanning microscopy	2136:2169	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	8	15	theme	thorax	969:974	arg1	properties					984:993	thorax cuticle properties	969:993	thorax cuticle properties	969:993	Our results suggest that thorax cuticle properties are highly dependent on anatomical region and species.
34740857	19	16	dep	not	2536:2538	arg1	modulus					2546:2552	mean modulus	2541:2552	mean modulus	2541:2552	This variation highlights the importance of high resolution cuticle assessment for flying insect lineages and points to factors that may (modulus gradation) and may not (mean modulus) contribute to different flight forms.
34740857	5	17	theme	Manduca	637:643	arg1	sexta					645:649	hawkmoth; Manduca sexta	627:649	hawkmoth; Manduca sexta	627:649	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	5	17	theme	Manduca	637:643	arg1	synchronous					614:624	synchronous	614:624	synchronous	614:624	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	10	18	contain	had	1163:1165	arg2	gradient					1193:1200	a positive linear modulus gradient	1167:1200	a positive linear modulus gradient	1167:1200	In some regions, A. mellifera had a positive linear modulus gradient from cuticle interior to exterior of about 2 GPa.
34740857	10	18	contain	had	1163:1165	arg1	mellifera					1153:1161	A. mellifera	1150:1161	A. mellifera	1150:1161	In some regions, A. mellifera had a positive linear modulus gradient from cuticle interior to exterior of about 2 GPa.
34740857	16	19	theme	insect	1850:1855	arg1	thorax					1857:1862	The insect thorax	1846:1862	STATEMENT OF SIGNIFICANCE: The insect thorax	1819:1862	STATEMENT OF SIGNIFICANCE: The insect thorax is essential for efficient flight but questions remain about the contribution of the exoskeletal cuticle.
34740857	18	20	theme	Apis	2304:2307	arg1	mellifera					2309:2317	Apis mellifera	2304:2317	honey bee; Apis mellifera	2293:2317	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	14	21	theme	cuticle	1630:1636	arg1	role					1598:1601	the protective role	1583:1601	the protective role of the A. mellifera thorax cuticle	1583:1636	These results support the protective role of the A. mellifera thorax cuticle.
34740857	20	22	theme	technologies	2661:2672	arg1	design					2651:2656	design	2651:2656	design of technologies inspired by insects, such as mobile micro robots	2651:2721	Understanding material variation in the thorax may inform design of technologies inspired by insects, such as mobile micro robots.
34740857	0	23	from	structure	54:62	arg1	heterogenous					38:49	heterogenous	38:49	heterogenous	38:49	The flying insect thoracic cuticle is heterogenous in structure and in thickness-dependent modulus gradation.
34740857	0	23	from	structure	54:62	arg1	cuticle					27:33	The flying insect thoracic cuticle	0:33	The flying insect thoracic cuticle	0:33	The flying insect thoracic cuticle is heterogenous in structure and in thickness-dependent modulus gradation.
34740857	14	24	theme	mellifera	1613:1621	arg1	cuticle					1630:1636	the A. mellifera thorax cuticle	1606:1636	the A. mellifera thorax cuticle	1606:1636	These results support the protective role of the A. mellifera thorax cuticle.
34740857	18	25	dep	asynchronous	2279:2290	arg1	muscles					2362:2368	muscles	2362:2368	muscles	2362:2368	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	18	25	dep	asynchronous	2279:2290	arg1	bee					2299:2301	honey bee	2293:2301	honey bee; Apis mellifera	2293:2317	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	7	26	theme	scanning	879:886	arg1	microscopy					888:897	confocal laser scanning microscopy	864:897	confocal laser scanning microscopy	864:897	We investigated cuticle structure using histology, resilin distribution through confocal laser scanning microscopy, and modulus gradation with nanoindentation.
34740857	10	27	theme	positive	1169:1176	arg1	gradient					1193:1200	a positive linear modulus gradient	1167:1200	a positive linear modulus gradient	1167:1200	In some regions, A. mellifera had a positive linear modulus gradient from cuticle interior to exterior of about 2 GPa.
34740857	5	28	theme	hawkmoth	627:634	arg1	sexta					645:649	hawkmoth; Manduca sexta	627:649	hawkmoth; Manduca sexta	627:649	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	5	28	theme	hawkmoth	627:634	arg1	synchronous					614:624	synchronous	614:624	synchronous	614:624	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	1	29	theme	specialized	126:136	arg1	thorax					114:119	The thorax	110:119	The thorax	110:119	The thorax is a specialized structure central to insect flight.
34740857	1	29	theme	specialized	126:136	arg1	structure					138:146	a specialized structure	124:146	a specialized structure central to insect flight	124:171	The thorax is a specialized structure central to insect flight.
34740857	2	30	theme	thin	224:227	arg1	layer					229:233	a thin layer	222:233	a thin layer of cuticle	222:244	In the thorax, flight muscles are surrounded by a thin layer of cuticle.
34740857	1	31	theme	central	148:154	arg1	thorax					114:119	The thorax	110:119	The thorax	110:119	The thorax is a specialized structure central to insect flight.
34740857	1	31	theme	central	148:154	arg1	structure					138:146	a specialized structure	124:146	a specialized structure central to insect flight	124:171	The thorax is a specialized structure central to insect flight.
34740857	17	32	theme	cuticle	2026:2032	arg1	properties					2001:2010	the microscale properties	1986:2010	the microscale properties of the thorax cuticle, a crucial step to determine its role in flight	1986:2080	We investigated the microscale properties of the thorax cuticle, a crucial step to determine its role in flight.
34740857	20	33	theme	material	2607:2614	arg1	variation					2616:2624	material variation	2607:2624	material variation in the thorax	2607:2638	Understanding material variation in the thorax may inform design of technologies inspired by insects, such as mobile micro robots.
34740857	5	34	theme	cuticle	545:551	arg1	assessment					524:533	a multi-faceted assessment	508:533	a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles	508:658	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	1	35	theme	insect	159:164	arg1	flight					166:171	insect flight	159:171	insect flight	159:171	The thorax is a specialized structure central to insect flight.
34740857	4	36	theme	insect	469:474	arg1	taxa					476:479	insect taxa	469:479	insect taxa	469:479	However, these properties, as well as their variation throughout the thorax and between insect taxa, are not known.
34740857	10	37	theme	modulus	1185:1191	arg1	gradient					1193:1200	a positive linear modulus gradient	1167:1200	a positive linear modulus gradient	1167:1200	In some regions, A. mellifera had a positive linear modulus gradient from cuticle interior to exterior of about 2 GPa.
34740857	0	38	theme	modulus	91:97	arg1	gradation					99:107	thickness-dependent modulus gradation	71:107	thickness-dependent modulus gradation	71:107	The flying insect thoracic cuticle is heterogenous in structure and in thickness-dependent modulus gradation.
34740857	3	39	from	efficiency	345:354	arg1	flight					373:378	flight	373:378	flight	373:378	The structure, composition, and material properties of this chitinous structure may influence the efficiency of the thorax in flight.
34740857	15	40	theme	structural	1713:1722	arg1	heterogeneity					1737:1749	thorax cuticle structural and material heterogeneity	1698:1749	thorax cuticle structural and material heterogeneity	1698:1749	Our multi-faceted assessment advances our understanding of thorax cuticle structural and material heterogeneity and the potential benefits of material gradation to flying insects.
34740857	3	41	theme	structure	317:325	arg1	structure					251:259	structure	251:259	structure	251:259	The structure, composition, and material properties of this chitinous structure may influence the efficiency of the thorax in flight.
34740857	3	41	theme	structure	317:325	arg1	properties					288:297	material properties	279:297	material properties	279:297	The structure, composition, and material properties of this chitinous structure may influence the efficiency of the thorax in flight.
34740857	3	41	theme	structure	317:325	arg1	composition					262:272	composition	262:272	composition	262:272	The structure, composition, and material properties of this chitinous structure may influence the efficiency of the thorax in flight.
34740857	0	42	from	heterogenous	38:49	arg1	gradation					99:107	thickness-dependent modulus gradation	71:107	thickness-dependent modulus gradation	71:107	The flying insect thoracic cuticle is heterogenous in structure and in thickness-dependent modulus gradation.
34740857	0	42	from	heterogenous	38:49	arg1	structure					54:62	structure	54:62	structure	54:62	The flying insect thoracic cuticle is heterogenous in structure and in thickness-dependent modulus gradation.
34740857	13	43	with	cuticle	1487:1493	arg1	gradient					1509:1516	a linear gradient	1500:1516	a linear gradient	1500:1516	Stress was reduced when cuticle with a linear gradient was compressed from the high modulus side.
34740857	19	44	theme	mean	2541:2544	arg1	modulus					2546:2552	mean modulus	2541:2552	mean modulus	2541:2552	This variation highlights the importance of high resolution cuticle assessment for flying insect lineages and points to factors that may (modulus gradation) and may not (mean modulus) contribute to different flight forms.
34740857	5	45	theme	multi-faceted	510:522	arg1	assessment					524:533	a multi-faceted assessment	508:533	a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles	508:658	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	19	46	theme	different	2569:2577	arg1	forms					2586:2590	different flight forms	2569:2590	different flight forms	2569:2590	This variation highlights the importance of high resolution cuticle assessment for flying insect lineages and points to factors that may (modulus gradation) and may not (mean modulus) contribute to different flight forms.
34740857	7	47	theme	laser	873:877	arg1	microscopy					888:897	confocal laser scanning microscopy	864:897	confocal laser scanning microscopy	864:897	We investigated cuticle structure using histology, resilin distribution through confocal laser scanning microscopy, and modulus gradation with nanoindentation.
34740857	16	48	theme	cuticle	1961:1967	arg1	contribution					1929:1940	the contribution	1925:1940	the contribution of the exoskeletal cuticle	1925:1967	STATEMENT OF SIGNIFICANCE: The insect thorax is essential for efficient flight but questions remain about the contribution of the exoskeletal cuticle.
34740857	15	49	theme	heterogeneity	1737:1749	arg1	understanding					1681:1693	our understanding	1677:1693	our understanding of thorax cuticle structural and material heterogeneity	1677:1749	Our multi-faceted assessment advances our understanding of thorax cuticle structural and material heterogeneity and the potential benefits of material gradation to flying insects.
34740857	15	49	theme	heterogeneity	1737:1749	arg1	benefits					1769:1776	the potential benefits	1755:1776	the potential benefits of material gradation to flying insects	1755:1816	Our multi-faceted assessment advances our understanding of thorax cuticle structural and material heterogeneity and the potential benefits of material gradation to flying insects.
34740857	18	50	dep	bee	2299:2301	arg1	mellifera					2309:2317	Apis mellifera	2304:2317	honey bee; Apis mellifera	2293:2317	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	0	51	theme	insect	11:16	arg1	heterogenous					38:49	heterogenous	38:49	heterogenous	38:49	The flying insect thoracic cuticle is heterogenous in structure and in thickness-dependent modulus gradation.
34740857	0	51	theme	insect	11:16	arg1	cuticle					27:33	The flying insect thoracic cuticle	0:33	The flying insect thoracic cuticle	0:33	The flying insect thoracic cuticle is heterogenous in structure and in thickness-dependent modulus gradation.
34740857	20	52	from	variation	2616:2624	arg1	thorax					2633:2638	the thorax	2629:2638	the thorax	2629:2638	Understanding material variation in the thorax may inform design of technologies inspired by insects, such as mobile micro robots.
34740857	9	53	theme	mean	1077:1080	arg1	modulus					1082:1088	mean modulus	1077:1088	mean modulus	1077:1088	Modulus gradation, but not mean modulus, differed between the two types of fliers.
34740857	19	54	theme	high	2415:2418	arg1	assessment					2439:2448	high resolution cuticle assessment	2415:2448	high resolution cuticle assessment	2415:2448	This variation highlights the importance of high resolution cuticle assessment for flying insect lineages and points to factors that may (modulus gradation) and may not (mean modulus) contribute to different flight forms.
34740857	5	55	dep	asynchronous	569:580	arg1	muscles					652:658	muscles	652:658	muscles	652:658	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	5	55	dep	asynchronous	569:580	arg1	bee					589:591	honey bee	583:591	honey bee; Apis mellifera	583:607	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	12	56	theme	modulus	1407:1413	arg1	gradients					1415:1423	measured modulus gradients	1398:1423	measured modulus gradients	1398:1423	We utilized finite element modeling to assess how measured modulus gradients influenced maximum stress in cuticle.
34740857	2	57	theme	flight	189:194	arg1	muscles					196:202	flight muscles	189:202	flight muscles	189:202	In the thorax, flight muscles are surrounded by a thin layer of cuticle.
34740857	7	58	theme	confocal	864:871	arg1	microscopy					888:897	confocal laser scanning microscopy	864:897	confocal laser scanning microscopy	864:897	We investigated cuticle structure using histology, resilin distribution through confocal laser scanning microscopy, and modulus gradation with nanoindentation.
34740857	19	59	theme	cuticle	2431:2437	arg1	assessment					2439:2448	high resolution cuticle assessment	2415:2448	high resolution cuticle assessment	2415:2448	This variation highlights the importance of high resolution cuticle assessment for flying insect lineages and points to factors that may (modulus gradation) and may not (mean modulus) contribute to different flight forms.
34740857	19	60	theme	resolution	2420:2429	arg1	assessment					2439:2448	high resolution cuticle assessment	2415:2448	high resolution cuticle assessment	2415:2448	This variation highlights the importance of high resolution cuticle assessment for flying insect lineages and points to factors that may (modulus gradation) and may not (mean modulus) contribute to different flight forms.
34740857	3	61	dep	structure	251:259	arg1	The					247:249	The	247:249	The	247:249	The structure, composition, and material properties of this chitinous structure may influence the efficiency of the thorax in flight.
34740857	7	62	with	histology	824:832	arg1	nanoindentation					927:941	nanoindentation	927:941	nanoindentation	927:941	We investigated cuticle structure using histology, resilin distribution through confocal laser scanning microscopy, and modulus gradation with nanoindentation.
34740857	15	63	theme	gradation	1790:1798	arg1	understanding					1681:1693	our understanding	1677:1693	our understanding of thorax cuticle structural and material heterogeneity	1677:1749	Our multi-faceted assessment advances our understanding of thorax cuticle structural and material heterogeneity and the potential benefits of material gradation to flying insects.
34740857	15	63	theme	gradation	1790:1798	arg1	benefits					1769:1776	the potential benefits	1755:1776	the potential benefits of material gradation to flying insects	1755:1816	Our multi-faceted assessment advances our understanding of thorax cuticle structural and material heterogeneity and the potential benefits of material gradation to flying insects.
34740857	20	64	theme	micro	2710:2714	arg1	robots					2716:2721	mobile micro robots	2703:2721	mobile micro robots	2703:2721	Understanding material variation in the thorax may inform design of technologies inspired by insects, such as mobile micro robots.
34740857	19	65	theme	insect	2461:2466	arg1	lineages					2468:2475	flying insect lineages	2454:2475	flying insect lineages	2454:2475	This variation highlights the importance of high resolution cuticle assessment for flying insect lineages and points to factors that may (modulus gradation) and may not (mean modulus) contribute to different flight forms.
34740857	12	66	used	utilized	1351:1358	arg2	We					1348:1349	We	1348:1349	We	1348:1349	We utilized finite element modeling to assess how measured modulus gradients influenced maximum stress in cuticle.
34740857	18	67	theme	cuticle	2217:2223	arg1	thickness					2225:2233	cuticle thickness	2217:2233	cuticle thickness	2217:2233	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	6	68	theme	activation	726:735	arg1	frequency					737:745	their activation frequency	720:745	their activation frequency	720:745	These muscle types are defined by the relationship between their activation frequency and the insect's wingbeat frequency.
34740857	13	69	theme	high	1542:1545	arg1	side					1555:1558	the high modulus side	1538:1558	the high modulus side	1538:1558	Stress was reduced when cuticle with a linear gradient was compressed from the high modulus side.
34740857	7	70	theme	cuticle	800:806	arg1	structure					808:816	cuticle structure	800:816	cuticle structure	800:816	We investigated cuticle structure using histology, resilin distribution through confocal laser scanning microscopy, and modulus gradation with nanoindentation.
34740857	16	71	theme	SIGNIFICANCE	1832:1843	arg1	STATEMENT					1819:1827	STATEMENT	1819:1827	STATEMENT OF SIGNIFICANCE: The insect thorax	1819:1862	STATEMENT OF SIGNIFICANCE: The insect thorax is essential for efficient flight but questions remain about the contribution of the exoskeletal cuticle.
34740857	12	72	theme	element	1367:1373	arg1	modeling					1375:1382	finite element modeling	1360:1382	finite element modeling	1360:1382	We utilized finite element modeling to assess how measured modulus gradients influenced maximum stress in cuticle.
34740857	17	73	theme	crucial	2037:2043	arg1	step					2045:2048	a crucial step	2035:2048	a crucial step to determine its role in flight	2035:2080	We investigated the microscale properties of the thorax cuticle, a crucial step to determine its role in flight.
34740857	17	73	theme	crucial	2037:2043	arg1	cuticle					2026:2032	the thorax cuticle	2015:2032	the thorax cuticle	2015:2032	We investigated the microscale properties of the thorax cuticle, a crucial step to determine its role in flight.
34740857	5	74	theme	honey	583:587	arg1	bee					589:591	honey bee	583:591	honey bee; Apis mellifera	583:607	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	13	75	theme	linear	1502:1507	arg1	gradient					1509:1516	a linear gradient	1500:1516	a linear gradient	1500:1516	Stress was reduced when cuticle with a linear gradient was compressed from the high modulus side.
34740857	18	76	theme	scanning	2151:2158	arg1	microscopy					2160:2169	confocal laser scanning microscopy	2136:2169	confocal laser scanning microscopy	2136:2169	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	8	77	theme	cuticle	976:982	arg1	properties					984:993	thorax cuticle properties	969:993	thorax cuticle properties	969:993	Our results suggest that thorax cuticle properties are highly dependent on anatomical region and species.
34740857	11	78	theme	M.	1255:1256	arg1	sexta					1258:1262	M. sexta	1255:1262	M. sexta	1255:1262	In M. sexta, modulus values through cuticle thickness were not well represented by linear fits.
34740857	18	79	theme	confocal	2136:2143	arg1	microscopy					2160:2169	confocal laser scanning microscopy	2136:2169	confocal laser scanning microscopy	2136:2169	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	11	80	theme	cuticle	1288:1294	arg1	thickness					1296:1304	cuticle thickness	1288:1304	cuticle thickness	1288:1304	In M. sexta, modulus values through cuticle thickness were not well represented by linear fits.
34740857	5	81	with	fliers	557:562	arg1	asynchronous					569:580	asynchronous	569:580	asynchronous	569:580	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	5	81	with	fliers	557:562	arg1	sexta					645:649	hawkmoth; Manduca sexta	627:649	hawkmoth; Manduca sexta	627:649	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	5	81	with	fliers	557:562	arg1	synchronous					614:624	synchronous	614:624	synchronous	614:624	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	18	82	theme	honey	2293:2297	arg1	bee					2299:2301	honey bee	2293:2301	honey bee; Apis mellifera	2293:2317	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	14	83	theme	thorax	1623:1628	arg1	cuticle					1630:1636	the A. mellifera thorax cuticle	1606:1636	the A. mellifera thorax cuticle	1606:1636	These results support the protective role of the A. mellifera thorax cuticle.
34740857	7	84	with	gradation	912:920	arg1	nanoindentation					927:941	nanoindentation	927:941	nanoindentation	927:941	We investigated cuticle structure using histology, resilin distribution through confocal laser scanning microscopy, and modulus gradation with nanoindentation.
34740857	11	85	dep	linear	1335:1340	arg1	fits					1342:1345	fits	1342:1345	fits	1342:1345	In M. sexta, modulus values through cuticle thickness were not well represented by linear fits.
34740857	6	86	theme	wingbeat	764:771	arg1	frequency					773:781	the insect's wingbeat frequency	751:781	the insect's wingbeat frequency	751:781	These muscle types are defined by the relationship between their activation frequency and the insect's wingbeat frequency.
34740857	17	87	theme	microscale	1990:1999	arg1	properties					2001:2010	the microscale properties	1986:2010	the microscale properties of the thorax cuticle, a crucial step to determine its role in flight	1986:2080	We investigated the microscale properties of the thorax cuticle, a crucial step to determine its role in flight.
34740857	10	88	theme	linear	1178:1183	arg1	gradient					1193:1200	a positive linear modulus gradient	1167:1200	a positive linear modulus gradient	1167:1200	In some regions, A. mellifera had a positive linear modulus gradient from cuticle interior to exterior of about 2 GPa.
34740857	14	89	theme	A.	1610:1611	arg1	cuticle					1630:1636	the A. mellifera thorax cuticle	1606:1636	the A. mellifera thorax cuticle	1606:1636	These results support the protective role of the A. mellifera thorax cuticle.
34740857	2	90	theme	cuticle	238:244	arg1	layer					229:233	a thin layer	222:233	a thin layer of cuticle	222:244	In the thorax, flight muscles are surrounded by a thin layer of cuticle.
34740857	0	91	from	gradation	99:107	arg1	heterogenous					38:49	heterogenous	38:49	heterogenous	38:49	The flying insect thoracic cuticle is heterogenous in structure and in thickness-dependent modulus gradation.
34740857	19	92	theme	modulus	2509:2515	arg1	gradation					2517:2525	modulus gradation	2509:2525	modulus gradation	2509:2525	This variation highlights the importance of high resolution cuticle assessment for flying insect lineages and points to factors that may (modulus gradation) and may not (mean modulus) contribute to different flight forms.
34740857	3	93	theme	chitinous	307:315	arg1	structure					317:325	this chitinous structure	302:325	this chitinous structure	302:325	The structure, composition, and material properties of this chitinous structure may influence the efficiency of the thorax in flight.
34740857	17	94	theme	thorax	2019:2024	arg1	step					2045:2048	a crucial step	2035:2048	a crucial step to determine its role in flight	2035:2080	We investigated the microscale properties of the thorax cuticle, a crucial step to determine its role in flight.
34740857	17	94	theme	thorax	2019:2024	arg1	cuticle					2026:2032	the thorax cuticle	2015:2032	the thorax cuticle	2015:2032	We investigated the microscale properties of the thorax cuticle, a crucial step to determine its role in flight.
34740857	10	95	theme	cuticle	1207:1213	arg1	interior					1215:1222	cuticle interior	1207:1222	cuticle interior to exterior of about 2 GPa	1207:1249	In some regions, A. mellifera had a positive linear modulus gradient from cuticle interior to exterior of about 2 GPa.
34740857	19	96	dep	may	2504:2506	arg1	gradation					2517:2525	modulus gradation	2509:2525	modulus gradation	2509:2525	This variation highlights the importance of high resolution cuticle assessment for flying insect lineages and points to factors that may (modulus gradation) and may not (mean modulus) contribute to different flight forms.
34740857	0	97	theme	thickness-dependent	71:89	arg1	gradation					99:107	thickness-dependent modulus gradation	71:107	thickness-dependent modulus gradation	71:107	The flying insect thoracic cuticle is heterogenous in structure and in thickness-dependent modulus gradation.
34740857	14	98	theme	protective	1587:1596	arg1	role					1598:1601	the protective role	1583:1601	the protective role of the A. mellifera thorax cuticle	1583:1636	These results support the protective role of the A. mellifera thorax cuticle.
34740857	15	99	theme	multi-faceted	1643:1655	arg1	assessment					1657:1666	Our multi-faceted assessment	1639:1666	Our multi-faceted assessment	1639:1666	Our multi-faceted assessment advances our understanding of thorax cuticle structural and material heterogeneity and the potential benefits of material gradation to flying insects.
34740857	19	100	theme	flight	2579:2584	arg1	forms					2586:2590	different flight forms	2569:2590	different flight forms	2569:2590	This variation highlights the importance of high resolution cuticle assessment for flying insect lineages and points to factors that may (modulus gradation) and may not (mean modulus) contribute to different flight forms.
34740857	15	101	theme	potential	1759:1767	arg1	benefits					1769:1776	the potential benefits	1755:1776	the potential benefits of material gradation to flying insects	1755:1816	Our multi-faceted assessment advances our understanding of thorax cuticle structural and material heterogeneity and the potential benefits of material gradation to flying insects.
34740857	8	102	theme	anatomical	1019:1028	arg1	region					1030:1035	anatomical region	1019:1035	anatomical region	1019:1035	Our results suggest that thorax cuticle properties are highly dependent on anatomical region and species.
34740857	7	103	theme	modulus	904:910	arg1	gradation					912:920	modulus gradation	904:920	modulus gradation with nanoindentation	904:941	We investigated cuticle structure using histology, resilin distribution through confocal laser scanning microscopy, and modulus gradation with nanoindentation.
34740857	16	104	theme	exoskeletal	1949:1959	arg1	cuticle					1961:1967	the exoskeletal cuticle	1945:1967	the exoskeletal cuticle	1945:1967	STATEMENT OF SIGNIFICANCE: The insect thorax is essential for efficient flight but questions remain about the contribution of the exoskeletal cuticle.
34740857	9	105	theme	Modulus	1050:1056	arg1	gradation					1058:1066	Modulus gradation	1050:1066	Modulus gradation	1050:1066	Modulus gradation, but not mean modulus, differed between the two types of fliers.
34740857	0	106	theme	flying	4:9	arg1	heterogenous					38:49	heterogenous	38:49	heterogenous	38:49	The flying insect thoracic cuticle is heterogenous in structure and in thickness-dependent modulus gradation.
34740857	0	106	theme	flying	4:9	arg1	cuticle					27:33	The flying insect thoracic cuticle	0:33	The flying insect thoracic cuticle	0:33	The flying insect thoracic cuticle is heterogenous in structure and in thickness-dependent modulus gradation.
34740857	18	107	with	species	2266:2272	arg1	asynchronous					2279:2290	asynchronous	2279:2290	asynchronous	2279:2290	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	18	107	with	species	2266:2272	arg1	sexta					2355:2359	hawkmoth; Manduca sexta	2337:2359	hawkmoth; Manduca sexta	2337:2359	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	18	107	with	species	2266:2272	arg1	synchronous					2324:2334	synchronous	2324:2334	synchronous	2324:2334	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	3	108	theme	thorax	363:368	arg1	efficiency					345:354	the efficiency	341:354	the efficiency of the thorax in flight	341:378	The structure, composition, and material properties of this chitinous structure may influence the efficiency of the thorax in flight.
34740857	15	109	theme	material	1728:1735	arg1	heterogeneity					1737:1749	thorax cuticle structural and material heterogeneity	1698:1749	thorax cuticle structural and material heterogeneity	1698:1749	Our multi-faceted assessment advances our understanding of thorax cuticle structural and material heterogeneity and the potential benefits of material gradation to flying insects.
34740857	0	110	theme	thoracic	18:25	arg1	heterogenous					38:49	heterogenous	38:49	heterogenous	38:49	The flying insect thoracic cuticle is heterogenous in structure and in thickness-dependent modulus gradation.
34740857	0	110	theme	thoracic	18:25	arg1	cuticle					27:33	The flying insect thoracic cuticle	0:33	The flying insect thoracic cuticle	0:33	The flying insect thoracic cuticle is heterogenous in structure and in thickness-dependent modulus gradation.
34740857	5	111	theme	thorax	538:543	arg1	cuticle					545:551	thorax cuticle	538:551	thorax cuticle	538:551	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	10	112	theme	2 GPa	1245:1249	arg1	exterior					1227:1234	exterior	1227:1234	exterior of about 2 GPa	1227:1249	In some regions, A. mellifera had a positive linear modulus gradient from cuticle interior to exterior of about 2 GPa.
34740857	12	113	theme	maximum	1436:1442	arg1	stress					1444:1449	maximum stress	1436:1449	maximum stress in cuticle	1436:1460	We utilized finite element modeling to assess how measured modulus gradients influenced maximum stress in cuticle.
34740857	16	114	theme	efficient	1881:1889	arg1	flight					1891:1896	efficient flight	1881:1896	efficient flight	1881:1896	STATEMENT OF SIGNIFICANCE: The insect thorax is essential for efficient flight but questions remain about the contribution of the exoskeletal cuticle.
34740857	5	115	dep	bee	589:591	arg1	mellifera					599:607	Apis mellifera	594:607	honey bee; Apis mellifera	583:607	We provide a multi-faceted assessment of thorax cuticle for fliers with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	17	116	from	role	2067:2070	arg1	flight					2075:2080	flight	2075:2080	flight	2075:2080	We investigated the microscale properties of the thorax cuticle, a crucial step to determine its role in flight.
34740857	18	117	theme	cuticle	2185:2191	arg1	properties					2193:2202	cuticle properties	2185:2202	cuticle properties	2185:2202	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	16	118	dep	STATEMENT	1819:1827	arg1	thorax					1857:1862	The insect thorax	1846:1862	STATEMENT OF SIGNIFICANCE: The insect thorax	1819:1862	STATEMENT OF SIGNIFICANCE: The insect thorax is essential for efficient flight but questions remain about the contribution of the exoskeletal cuticle.
34740857	12	119	theme	measured	1398:1405	arg1	gradients					1415:1423	measured modulus gradients	1398:1423	measured modulus gradients	1398:1423	We utilized finite element modeling to assess how measured modulus gradients influenced maximum stress in cuticle.
34740857	6	120	theme	muscle	667:672	arg1	types					674:678	These muscle types	661:678	These muscle types	661:678	These muscle types are defined by the relationship between their activation frequency and the insect's wingbeat frequency.
34740857	7	121	theme	resilin	835:841	arg1	distribution					843:854	resilin distribution	835:854	resilin distribution through confocal laser scanning microscopy	835:897	We investigated cuticle structure using histology, resilin distribution through confocal laser scanning microscopy, and modulus gradation with nanoindentation.
34740857	19	122	theme	flying	2454:2459	arg1	lineages					2468:2475	flying insect lineages	2454:2475	flying insect lineages	2454:2475	This variation highlights the importance of high resolution cuticle assessment for flying insect lineages and points to factors that may (modulus gradation) and may not (mean modulus) contribute to different flight forms.
34740857	18	123	theme	thorax	2239:2244	arg1	region					2246:2251	thorax region	2239:2251	thorax region	2239:2251	Techniques including histology, nanoindentation, and confocal laser scanning microscopy revealed that cuticle properties vary through cuticle thickness, by thorax region, and between species with asynchronous (honey bee; Apis mellifera) and synchronous (hawkmoth; Manduca sexta) muscles.
34740857	19	124	theme	assessment	2439:2448	arg1	importance					2401:2410	the importance	2397:2410	the importance of high resolution cuticle assessment for flying insect lineages	2397:2475	This variation highlights the importance of high resolution cuticle assessment for flying insect lineages and points to factors that may (modulus gradation) and may not (mean modulus) contribute to different flight forms.
34280764	4	0	theme	3D	523:524	arg1	NCXs					567:570	NCXs	567:570	NCXs	567:570	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	0	theme	3D	523:524	arg1	xerogels					557:564	3D sucrose-derived N-doped carbon xerogels	523:564	3D sucrose-derived N-doped carbon xerogels (NCXs)	523:571	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	0	theme	3D	523:524	arg1	activators					681:690	novel metal-free PDS activators	660:690	novel metal-free PDS activators	660:690	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	1	1	from	pollutants	200:209	arg1	water					214:218	water	214:218	water	214:218	Metal-free activation of peroxydisulfate (PDS) for degrading organic pollutants in water has received increasing attention because it can prevent secondary pollution.
34280764	9	2	with	pollutants	1338:1347	arg1	potentials					1369:1378	low ionization potentials	1354:1378	low ionization potentials	1354:1378	With this non-radical mechanism, the NCX900/PDS system could adapt well to the wide pH range (3-11) and high Cl- concentration; it selectively oxidized organic pollutants with low ionization potentials.
34280764	1	3	theme	secondary	277:285	arg1	pollution					287:295	secondary pollution	277:295	secondary pollution	277:295	Metal-free activation of peroxydisulfate (PDS) for degrading organic pollutants in water has received increasing attention because it can prevent secondary pollution.
34280764	5	4	theme	carbonization	805:817	arg1	temperature					819:829	the carbonization temperature	801:829	the carbonization temperature	801:829	The structure, composition and performance of NCXs were regulated by changing the carbonization temperature.
34280764	4	5	theme	carbon	550:555	arg1	NCXs					567:570	NCXs	567:570	NCXs	567:570	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	5	theme	carbon	550:555	arg1	xerogels					557:564	3D sucrose-derived N-doped carbon xerogels	523:564	3D sucrose-derived N-doped carbon xerogels (NCXs)	523:571	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	5	theme	carbon	550:555	arg1	activators					681:690	novel metal-free PDS activators	660:690	novel metal-free PDS activators	660:690	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	10	6	theme	efficient	1443:1451	arg1	catalysts					1464:1472	the low-cost and efficient metal-free catalysts	1426:1472	the low-cost and efficient metal-free catalysts	1426:1472	This work provides a sustainable approach to the low-cost and efficient metal-free catalysts for wastewater treatment.
34280764	1	7	theme	degrading	182:190	arg1	pollutants					200:209	degrading organic pollutants	182:209	degrading organic pollutants in water	182:218	Metal-free activation of peroxydisulfate (PDS) for degrading organic pollutants in water has received increasing attention because it can prevent secondary pollution.
34280764	4	8	theme	simple	595:600	arg1	process					631:637	a simple and sustainable hydrothermal process	593:637	a simple and sustainable hydrothermal process	593:637	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	0	9	theme	pollutants	119:128	arg1	degradation					96:106	non-radical degradation	84:106	non-radical degradation of organic pollutants	84:128	Sucrose-derived N-doped carbon xerogels as efficient peroxydisulfate activators for non-radical degradation of organic pollutants.
34280764	4	10	theme	N-doped	542:548	arg1	NCXs					567:570	NCXs	567:570	NCXs	567:570	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	10	theme	N-doped	542:548	arg1	xerogels					557:564	3D sucrose-derived N-doped carbon xerogels	523:564	3D sucrose-derived N-doped carbon xerogels (NCXs)	523:571	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	10	theme	N-doped	542:548	arg1	activators					681:690	novel metal-free PDS activators	660:690	novel metal-free PDS activators	660:690	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	2	11	theme	fossil	379:384	arg1	resources					386:394	non-renewable fossil resources	365:394	non-renewable fossil resources	365:394	However, most of the catalysts that are efficient are derived from non-renewable fossil resources, are very expensive and have complex preparation processes.
34280764	4	12	theme	hydrothermal	618:629	arg1	process					631:637	a simple and sustainable hydrothermal process	593:637	a simple and sustainable hydrothermal process	593:637	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	0	13	theme	organic	111:117	arg1	pollutants					119:128	organic pollutants	111:128	organic pollutants	111:128	Sucrose-derived N-doped carbon xerogels as efficient peroxydisulfate activators for non-radical degradation of organic pollutants.
34280764	10	14	theme	low-cost	1430:1437	arg1	catalysts					1464:1472	the low-cost and efficient metal-free catalysts	1426:1472	the low-cost and efficient metal-free catalysts	1426:1472	This work provides a sustainable approach to the low-cost and efficient metal-free catalysts for wastewater treatment.
34280764	4	15	theme	sustainable	606:616	arg1	process					631:637	a simple and sustainable hydrothermal process	593:637	a simple and sustainable hydrothermal process	593:637	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	6	16	from	A	945:945	arg1	60 min					950:955	60 min	950:955	60 min	950:955	The sample carbonized at 900 °C (NCX900) exhibited the best catalytic performance, completely removing bisphenol A in 60 min.
34280764	6	17	theme	bisphenol	935:943	arg1	A					945:945	bisphenol A	935:945	bisphenol A in 60 min	935:955	The sample carbonized at 900 °C (NCX900) exhibited the best catalytic performance, completely removing bisphenol A in 60 min.
34280764	8	18	theme	graphitic	1124:1132	arg1	N					1134:1134	graphitic N	1124:1134	graphitic N	1124:1134	It was found that graphitic N played a critical role in activating PDS.
34280764	0	19	link	Sucrose-derived	0:14	arg1	carbon					24:29	Sucrose-derived N-doped carbon	0:29	Sucrose-derived N-doped carbon	0:29	Sucrose-derived N-doped carbon xerogels as efficient peroxydisulfate activators for non-radical degradation of organic pollutants.
34280764	4	20	theme	organic	703:709	arg1	pollutants					711:720	organic pollutants	703:720	organic pollutants	703:720	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	1	21	theme	organic	192:198	arg1	pollutants					200:209	degrading organic pollutants	182:209	degrading organic pollutants in water	182:218	Metal-free activation of peroxydisulfate (PDS) for degrading organic pollutants in water has received increasing attention because it can prevent secondary pollution.
34280764	9	22	theme	ionization	1358:1367	arg1	potentials					1369:1378	low ionization potentials	1354:1378	low ionization potentials	1354:1378	With this non-radical mechanism, the NCX900/PDS system could adapt well to the wide pH range (3-11) and high Cl- concentration; it selectively oxidized organic pollutants with low ionization potentials.
34280764	5	23	dep	structure	727:735	arg1	The					723:725	The	723:725	The	723:725	The structure, composition and performance of NCXs were regulated by changing the carbonization temperature.
34280764	6	24	theme	best	887:890	arg1	performance					902:912	the best catalytic performance	883:912	the best catalytic performance	883:912	The sample carbonized at 900 °C (NCX900) exhibited the best catalytic performance, completely removing bisphenol A in 60 min.
34280764	3	25	theme	emerging	466:473	arg1	mechanism					487:495	the emerging non-radical mechanism	462:495	the emerging non-radical mechanism	462:495	Also, the emerging non-radical mechanism is still unclear.
34280764	3	25	theme	emerging	466:473	arg1	unclear					506:512	unclear	506:512	unclear	506:512	Also, the emerging non-radical mechanism is still unclear.
34280764	0	26	theme	N-doped	16:22	arg1	carbon					24:29	Sucrose-derived N-doped carbon	0:29	Sucrose-derived N-doped carbon	0:29	Sucrose-derived N-doped carbon xerogels as efficient peroxydisulfate activators for non-radical degradation of organic pollutants.
34280764	10	27	theme	wastewater	1478:1487	arg1	treatment					1489:1497	wastewater treatment	1478:1497	wastewater treatment	1478:1497	This work provides a sustainable approach to the low-cost and efficient metal-free catalysts for wastewater treatment.
34280764	7	28	theme	sweep	991:995	arg1	voltammograms					997:1009	linear sweep voltammograms	984:1009	linear sweep voltammograms	984:1009	Quenching experiments and linear sweep voltammograms demonstrated that PDS was activated mainly through an electron-transfer non-radical mechanism.
34280764	9	29	theme	low	1354:1356	arg1	potentials					1369:1378	low ionization potentials	1354:1378	low ionization potentials	1354:1378	With this non-radical mechanism, the NCX900/PDS system could adapt well to the wide pH range (3-11) and high Cl- concentration; it selectively oxidized organic pollutants with low ionization potentials.
34280764	4	30	theme	PDS	677:679	arg1	xerogels					557:564	3D sucrose-derived N-doped carbon xerogels	523:564	3D sucrose-derived N-doped carbon xerogels (NCXs)	523:571	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	30	theme	PDS	677:679	arg1	activators					681:690	novel metal-free PDS activators	660:690	novel metal-free PDS activators	660:690	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	0	31	theme	Sucrose-derived	0:14	arg1	carbon					24:29	Sucrose-derived N-doped carbon	0:29	Sucrose-derived N-doped carbon	0:29	Sucrose-derived N-doped carbon xerogels as efficient peroxydisulfate activators for non-radical degradation of organic pollutants.
34280764	8	32	theme	critical	1145:1152	arg1	role					1154:1157	a critical role	1143:1157	a critical role	1143:1157	It was found that graphitic N played a critical role in activating PDS.
34280764	10	33	theme	metal-free	1453:1462	arg1	catalysts					1464:1472	the low-cost and efficient metal-free catalysts	1426:1472	the low-cost and efficient metal-free catalysts	1426:1472	This work provides a sustainable approach to the low-cost and efficient metal-free catalysts for wastewater treatment.
34280764	4	34	theme	novel	660:664	arg1	xerogels					557:564	3D sucrose-derived N-doped carbon xerogels	523:564	3D sucrose-derived N-doped carbon xerogels (NCXs)	523:571	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	34	theme	novel	660:664	arg1	activators					681:690	novel metal-free PDS activators	660:690	novel metal-free PDS activators	660:690	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	35	link	sucrose-derived	526:540	arg1	NCXs					567:570	NCXs	567:570	NCXs	567:570	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	35	link	sucrose-derived	526:540	arg1	xerogels					557:564	3D sucrose-derived N-doped carbon xerogels	523:564	3D sucrose-derived N-doped carbon xerogels (NCXs)	523:571	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	35	link	sucrose-derived	526:540	arg1	activators					681:690	novel metal-free PDS activators	660:690	novel metal-free PDS activators	660:690	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	9	36	theme	high	1282:1285	arg1	concentration					1291:1303	high Cl- concentration	1282:1303	high Cl- concentration	1282:1303	With this non-radical mechanism, the NCX900/PDS system could adapt well to the wide pH range (3-11) and high Cl- concentration; it selectively oxidized organic pollutants with low ionization potentials.
34280764	1	37	theme	Metal-free	131:140	arg1	activation					142:151	Metal-free activation	131:151	Metal-free activation of peroxydisulfate (PDS) for degrading organic pollutants in water	131:218	Metal-free activation of peroxydisulfate (PDS) for degrading organic pollutants in water has received increasing attention because it can prevent secondary pollution.
34280764	0	38	theme	efficient	43:51	arg1	activators					69:78	efficient peroxydisulfate activators	43:78	efficient peroxydisulfate activators for non-radical degradation of organic pollutants	43:128	Sucrose-derived N-doped carbon xerogels as efficient peroxydisulfate activators for non-radical degradation of organic pollutants.
34280764	1	39	theme	increasing	233:242	arg1	attention					244:252	increasing attention because it can prevent secondary pollution	233:295	increasing attention because it can prevent secondary pollution	233:295	Metal-free activation of peroxydisulfate (PDS) for degrading organic pollutants in water has received increasing attention because it can prevent secondary pollution.
34280764	2	40	theme	preparation	433:443	arg1	processes					445:453	complex preparation processes	425:453	complex preparation processes	425:453	However, most of the catalysts that are efficient are derived from non-renewable fossil resources, are very expensive and have complex preparation processes.
34280764	6	41	theme	catalytic	892:900	arg1	performance					902:912	the best catalytic performance	883:912	the best catalytic performance	883:912	The sample carbonized at 900 °C (NCX900) exhibited the best catalytic performance, completely removing bisphenol A in 60 min.
34280764	7	42	theme	non-radical	1083:1093	arg1	mechanism					1095:1103	an electron-transfer non-radical mechanism	1062:1103	an electron-transfer non-radical mechanism	1062:1103	Quenching experiments and linear sweep voltammograms demonstrated that PDS was activated mainly through an electron-transfer non-radical mechanism.
34280764	2	43	theme	complex	425:431	arg1	processes					445:453	complex preparation processes	425:453	complex preparation processes	425:453	However, most of the catalysts that are efficient are derived from non-renewable fossil resources, are very expensive and have complex preparation processes.
34280764	2	44	contain	have	420:423	arg2	processes					445:453	complex preparation processes	425:453	complex preparation processes	425:453	However, most of the catalysts that are efficient are derived from non-renewable fossil resources, are very expensive and have complex preparation processes.
34280764	2	44	contain	have	420:423	arg1	most					307:310	most	307:310	most	307:310	However, most of the catalysts that are efficient are derived from non-renewable fossil resources, are very expensive and have complex preparation processes.
34280764	2	44	contain	have	420:423	arg1	catalysts					319:327	the catalysts	315:327	the catalysts	315:327	However, most of the catalysts that are efficient are derived from non-renewable fossil resources, are very expensive and have complex preparation processes.
34280764	9	45	theme	non-radical	1188:1198	arg1	mechanism					1200:1208	this non-radical mechanism	1183:1208	this non-radical mechanism	1183:1208	With this non-radical mechanism, the NCX900/PDS system could adapt well to the wide pH range (3-11) and high Cl- concentration; it selectively oxidized organic pollutants with low ionization potentials.
34280764	2	46	theme	non-renewable	365:377	arg1	resources					386:394	non-renewable fossil resources	365:394	non-renewable fossil resources	365:394	However, most of the catalysts that are efficient are derived from non-renewable fossil resources, are very expensive and have complex preparation processes.
34280764	0	47	theme	peroxydisulfate	53:67	arg1	activators					69:78	efficient peroxydisulfate activators	43:78	efficient peroxydisulfate activators for non-radical degradation of organic pollutants	43:128	Sucrose-derived N-doped carbon xerogels as efficient peroxydisulfate activators for non-radical degradation of organic pollutants.
34280764	9	48	theme	wide	1257:1260	arg1	3-11					1272:1275	3-11	1272:1275	3-11	1272:1275	With this non-radical mechanism, the NCX900/PDS system could adapt well to the wide pH range (3-11) and high Cl- concentration; it selectively oxidized organic pollutants with low ionization potentials.
34280764	9	48	theme	wide	1257:1260	arg1	range					1265:1269	the wide pH range	1253:1269	the wide pH range (3-11)	1253:1276	With this non-radical mechanism, the NCX900/PDS system could adapt well to the wide pH range (3-11) and high Cl- concentration; it selectively oxidized organic pollutants with low ionization potentials.
34280764	9	49	theme	Cl-	1287:1289	arg1	concentration					1291:1303	high Cl- concentration	1282:1303	high Cl- concentration	1282:1303	With this non-radical mechanism, the NCX900/PDS system could adapt well to the wide pH range (3-11) and high Cl- concentration; it selectively oxidized organic pollutants with low ionization potentials.
34280764	7	50	theme	linear	984:989	arg1	voltammograms					997:1009	linear sweep voltammograms	984:1009	linear sweep voltammograms	984:1009	Quenching experiments and linear sweep voltammograms demonstrated that PDS was activated mainly through an electron-transfer non-radical mechanism.
34280764	7	51	theme	electron-transfer	1065:1081	arg1	mechanism					1095:1103	an electron-transfer non-radical mechanism	1062:1103	an electron-transfer non-radical mechanism	1062:1103	Quenching experiments and linear sweep voltammograms demonstrated that PDS was activated mainly through an electron-transfer non-radical mechanism.
34280764	1	52	theme	peroxydisulfate	156:170	arg1	activation					142:151	Metal-free activation	131:151	Metal-free activation of peroxydisulfate (PDS) for degrading organic pollutants in water	131:218	Metal-free activation of peroxydisulfate (PDS) for degrading organic pollutants in water has received increasing attention because it can prevent secondary pollution.
34280764	7	53	theme	Quenching	958:966	arg1	experiments					968:978	Quenching experiments	958:978	Quenching experiments	958:978	Quenching experiments and linear sweep voltammograms demonstrated that PDS was activated mainly through an electron-transfer non-radical mechanism.
34280764	2	54	dep	efficient	338:346	arg1	derived					352:358	derived	352:358	are derived from non-renewable fossil resources	348:394	However, most of the catalysts that are efficient are derived from non-renewable fossil resources, are very expensive and have complex preparation processes.
34280764	0	55	theme	non-radical	84:94	arg1	degradation					96:106	non-radical degradation	84:106	non-radical degradation of organic pollutants	84:128	Sucrose-derived N-doped carbon xerogels as efficient peroxydisulfate activators for non-radical degradation of organic pollutants.
34280764	4	56	theme	metal-free	666:675	arg1	xerogels					557:564	3D sucrose-derived N-doped carbon xerogels	523:564	3D sucrose-derived N-doped carbon xerogels (NCXs)	523:571	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	56	theme	metal-free	666:675	arg1	activators					681:690	novel metal-free PDS activators	660:690	novel metal-free PDS activators	660:690	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	3	57	theme	non-radical	475:485	arg1	mechanism					487:495	the emerging non-radical mechanism	462:495	the emerging non-radical mechanism	462:495	Also, the emerging non-radical mechanism is still unclear.
34280764	3	57	theme	non-radical	475:485	arg1	unclear					506:512	unclear	506:512	unclear	506:512	Also, the emerging non-radical mechanism is still unclear.
34280764	9	58	theme	NCX900/PDS	1215:1224	arg1	system					1226:1231	the NCX900/PDS system	1211:1231	the NCX900/PDS system	1211:1231	With this non-radical mechanism, the NCX900/PDS system could adapt well to the wide pH range (3-11) and high Cl- concentration; it selectively oxidized organic pollutants with low ionization potentials.
34280764	9	59	theme	organic	1330:1336	arg1	pollutants					1338:1347	organic pollutants	1330:1347	organic pollutants with low ionization potentials	1330:1378	With this non-radical mechanism, the NCX900/PDS system could adapt well to the wide pH range (3-11) and high Cl- concentration; it selectively oxidized organic pollutants with low ionization potentials.
34280764	9	60	theme	pH	1262:1263	arg1	3-11					1272:1275	3-11	1272:1275	3-11	1272:1275	With this non-radical mechanism, the NCX900/PDS system could adapt well to the wide pH range (3-11) and high Cl- concentration; it selectively oxidized organic pollutants with low ionization potentials.
34280764	9	60	theme	pH	1262:1263	arg1	range					1265:1269	the wide pH range	1253:1269	the wide pH range (3-11)	1253:1276	With this non-radical mechanism, the NCX900/PDS system could adapt well to the wide pH range (3-11) and high Cl- concentration; it selectively oxidized organic pollutants with low ionization potentials.
34280764	4	61	theme	sucrose-derived	526:540	arg1	NCXs					567:570	NCXs	567:570	NCXs	567:570	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	61	theme	sucrose-derived	526:540	arg1	xerogels					557:564	3D sucrose-derived N-doped carbon xerogels	523:564	3D sucrose-derived N-doped carbon xerogels (NCXs)	523:571	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	4	61	theme	sucrose-derived	526:540	arg1	activators					681:690	novel metal-free PDS activators	660:690	novel metal-free PDS activators	660:690	Herein, 3D sucrose-derived N-doped carbon xerogels (NCXs) were synthesized by a simple and sustainable hydrothermal process and then employed as novel metal-free PDS activators to degrade organic pollutants.
34280764	10	62	theme	sustainable	1402:1412	arg1	approach					1414:1421	a sustainable approach	1400:1421	a sustainable approach to the low-cost and efficient metal-free catalysts for wastewater treatment	1400:1497	This work provides a sustainable approach to the low-cost and efficient metal-free catalysts for wastewater treatment.
34280764	5	63	theme	NCXs	769:772	arg1	composition					738:748	composition	738:748	composition	738:748	The structure, composition and performance of NCXs were regulated by changing the carbonization temperature.
34280764	5	63	theme	NCXs	769:772	arg1	structure					727:735	structure	727:735	structure	727:735	The structure, composition and performance of NCXs were regulated by changing the carbonization temperature.
34280764	5	63	theme	NCXs	769:772	arg1	performance					754:764	performance	754:764	performance	754:764	The structure, composition and performance of NCXs were regulated by changing the carbonization temperature.
32215793	8	0	theme	different	1150:1158	arg1	models					1169:1174	different kinetics models	1150:1174	different kinetics models	1150:1174	Further, the controlled and extended-release profile was observed at different physiological pH, and different kinetics models were used to understand the drug release mechanism.
32215793	3	1	from	solubility	386:395	arg1	solution					408:415	aqueous solution	400:415	aqueous solution	400:415	However, it has certain limitations like instability, low solubility in aqueous solution, and biological fluids.
32215793	8	2	theme	different	1118:1126	arg1	pH					1142:1143	different physiological pH	1118:1143	different physiological pH	1118:1143	Further, the controlled and extended-release profile was observed at different physiological pH, and different kinetics models were used to understand the drug release mechanism.
32215793	8	3	theme	kinetics	1160:1167	arg1	models					1169:1174	different kinetics models	1150:1174	different kinetics models	1150:1174	Further, the controlled and extended-release profile was observed at different physiological pH, and different kinetics models were used to understand the drug release mechanism.
32215793	1	4	theme	drug	248:251	arg1	release					223:229	the controlled release	208:229	the controlled release	208:229	In the present study, an application of cellulose nanofibers has been established for the controlled release of an anticancer drug, i.e., camptothecin.
32215793	0	5	theme	controlled	82:91	arg1	release					93:99	the controlled release	78:99	the controlled release of anticancer drugs	78:119	Application of enzyme-mediated cellulose nanofibers from lemongrass waste for the controlled release of anticancer drugs.
32215793	1	6	dep	camptothecin	260:271	arg1	i.e.					254:257	i.e.	254:257	i.e.	254:257	In the present study, an application of cellulose nanofibers has been established for the controlled release of an anticancer drug, i.e., camptothecin.
32215793	5	7	theme	10:3	629:632	arg1	ratio					646:650	the 10:3 composition ratio	625:650	the 10:3 composition ratio of cellulose nanofibers	625:674	In the 10:3 composition ratio of cellulose nanofibers, camptothecin showed the highest encapsulation efficiency, i.e., 65.28%.
32215793	7	8	theme	camptothecin	953:964	arg1	adsorption					939:948	physical adsorption	930:948	physical adsorption of camptothecin onto the homogeneous as well as the heterogeneous surface of cellulose nanofibers	930:1046	Also, the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies demonstrate physical adsorption of camptothecin onto the homogeneous as well as the heterogeneous surface of cellulose nanofibers.
32215793	7	9	theme	Langmuir	846:853	arg1	studies					910:916	the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies	842:916	the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies	842:916	Also, the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies demonstrate physical adsorption of camptothecin onto the homogeneous as well as the heterogeneous surface of cellulose nanofibers.
32215793	4	10	theme	nanofibers-camptothecin	569:591	arg1	ratio					550:554	the composition ratio	534:554	the composition ratio	534:554	Firstly, the camptothecin was encapsulated into the cellulose nanofiber complex by adjusting the composition ratio of cellulose nanofibers-camptothecin, i.e., 10:3, 10:5, and 10:7.
32215793	0	11	theme	anticancer	104:113	arg1	drugs					115:119	anticancer drugs	104:119	anticancer drugs	104:119	Application of enzyme-mediated cellulose nanofibers from lemongrass waste for the controlled release of anticancer drugs.
32215793	4	12	theme	cellulose	493:501	arg1	complex					513:519	the cellulose nanofiber complex	489:519	the cellulose nanofiber complex	489:519	Firstly, the camptothecin was encapsulated into the cellulose nanofiber complex by adjusting the composition ratio of cellulose nanofibers-camptothecin, i.e., 10:3, 10:5, and 10:7.
32215793	5	13	theme	composition	634:644	arg1	ratio					646:650	the 10:3 composition ratio	625:650	the 10:3 composition ratio of cellulose nanofibers	625:674	In the 10:3 composition ratio of cellulose nanofibers, camptothecin showed the highest encapsulation efficiency, i.e., 65.28%.
32215793	10	14	theme	chemical	1677:1684	arg1	excipients					1686:1695	any chemical excipients	1673:1695	any chemical excipients	1673:1695	Hence, the results established that enzyme-mediated cellulose nanofibers may also be an optimal carrier for the controlled drug release formulation without any chemical excipients.
32215793	9	15	theme	Higuchi	1382:1388	arg1	model					1390:1394	Higuchi model	1382:1394	Higuchi model	1382:1394	The highest correlation in all pH conditions was obtained in Korsmeyer-Peppas with R2 value = 0.93 (pH 1.2), 0.89 (pH 6.8), and 0.97 (pH 7.4), whereas in Higuchi model, R2 value = 0.89 (pH 1.2), 0.91 (pH 6.8), and 0.98 (pH 7.4), suggesting the release of a drug via a diffusion mechanism.
32215793	3	16	theme	certain	344:350	arg1	limitations					352:362	certain limitations	344:362	certain limitations	344:362	However, it has certain limitations like instability, low solubility in aqueous solution, and biological fluids.
32215793	6	17	theme	cellulose	782:790	arg1	nanofibers					792:801	cellulose nanofibers	782:801	cellulose nanofibers	782:801	The binding of camptothecin with cellulose nanofibers was confirmed by FT-IR analysis.
32215793	9	18	from	correlation	1240:1250	arg1	conditions					1262:1271	all pH conditions	1255:1271	all pH conditions	1255:1271	The highest correlation in all pH conditions was obtained in Korsmeyer-Peppas with R2 value = 0.93 (pH 1.2), 0.89 (pH 6.8), and 0.97 (pH 7.4), whereas in Higuchi model, R2 value = 0.89 (pH 1.2), 0.91 (pH 6.8), and 0.98 (pH 7.4), suggesting the release of a drug via a diffusion mechanism.
32215793	1	19	theme	cellulose	162:170	arg1	nanofibers					172:181	cellulose nanofibers	162:181	cellulose nanofibers	162:181	In the present study, an application of cellulose nanofibers has been established for the controlled release of an anticancer drug, i.e., camptothecin.
32215793	0	20	theme	drugs	115:119	arg1	release					93:99	the controlled release	78:99	the controlled release of anticancer drugs	78:119	Application of enzyme-mediated cellulose nanofibers from lemongrass waste for the controlled release of anticancer drugs.
32215793	3	21	from	instability	369:379	arg1	solution					408:415	aqueous solution	400:415	aqueous solution	400:415	However, it has certain limitations like instability, low solubility in aqueous solution, and biological fluids.
32215793	8	22	used	used	1181:1184	arg2	models					1169:1174	different kinetics models	1150:1174	different kinetics models	1150:1174	Further, the controlled and extended-release profile was observed at different physiological pH, and different kinetics models were used to understand the drug release mechanism.
32215793	6	23	theme	camptothecin	764:775	arg1	binding					753:759	The binding	749:759	The binding of camptothecin with cellulose nanofibers	749:801	The binding of camptothecin with cellulose nanofibers was confirmed by FT-IR analysis.
32215793	10	24	theme	release	1645:1651	arg1	formulation					1653:1663	the controlled drug release formulation	1625:1663	the controlled drug release formulation without any chemical excipients	1625:1695	Hence, the results established that enzyme-mediated cellulose nanofibers may also be an optimal carrier for the controlled drug release formulation without any chemical excipients.
32215793	1	25	theme	nanofibers	172:181	arg1	application					147:157	an application	144:157	an application of cellulose nanofibers	144:181	In the present study, an application of cellulose nanofibers has been established for the controlled release of an anticancer drug, i.e., camptothecin.
32215793	8	26	theme	controlled	1062:1071	arg1	profile					1094:1100	the controlled and extended-release profile	1058:1100	profile	1094:1100	Further, the controlled and extended-release profile was observed at different physiological pH, and different kinetics models were used to understand the drug release mechanism.
32215793	7	27	theme	physical	930:937	arg1	adsorption					939:948	physical adsorption	930:948	physical adsorption of camptothecin onto the homogeneous as well as the heterogeneous surface of cellulose nanofibers	930:1046	Also, the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies demonstrate physical adsorption of camptothecin onto the homogeneous as well as the heterogeneous surface of cellulose nanofibers.
32215793	8	28	theme	extended-release	1077:1092	arg1	profile					1094:1100	the controlled and extended-release profile	1058:1100	profile	1094:1100	Further, the controlled and extended-release profile was observed at different physiological pH, and different kinetics models were used to understand the drug release mechanism.
32215793	4	29	theme	nanofiber	503:511	arg1	complex					513:519	the cellulose nanofiber complex	489:519	the cellulose nanofiber complex	489:519	Firstly, the camptothecin was encapsulated into the cellulose nanofiber complex by adjusting the composition ratio of cellulose nanofibers-camptothecin, i.e., 10:3, 10:5, and 10:7.
32215793	7	30	theme	isotherm	901:908	arg1	studies					910:916	the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies	842:916	the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies	842:916	Also, the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies demonstrate physical adsorption of camptothecin onto the homogeneous as well as the heterogeneous surface of cellulose nanofibers.
32215793	0	31	theme	cellulose	31:39	arg1	Application					0:10	Application	0:10	Application of enzyme-mediated cellulose	0:39	Application of enzyme-mediated cellulose nanofibers from lemongrass waste for the controlled release of anticancer drugs.
32215793	4	32	theme	composition	538:548	arg1	ratio					550:554	the composition ratio	534:554	the composition ratio	534:554	Firstly, the camptothecin was encapsulated into the cellulose nanofiber complex by adjusting the composition ratio of cellulose nanofibers-camptothecin, i.e., 10:3, 10:5, and 10:7.
32215793	5	33	dep	%	746:746	arg1	i.e.					735:738	i.e.	735:738	i.e.	735:738	In the 10:3 composition ratio of cellulose nanofibers, camptothecin showed the highest encapsulation efficiency, i.e., 65.28%.
32215793	10	34	theme	cellulose	1569:1577	arg1	nanofibers					1579:1588	enzyme-mediated cellulose nanofibers	1553:1588	enzyme-mediated cellulose nanofibers	1553:1588	Hence, the results established that enzyme-mediated cellulose nanofibers may also be an optimal carrier for the controlled drug release formulation without any chemical excipients.
32215793	10	34	theme	cellulose	1569:1577	arg1	carrier					1613:1619	an optimal carrier	1602:1619	an optimal carrier for the controlled drug release formulation without any chemical excipients	1602:1695	Hence, the results established that enzyme-mediated cellulose nanofibers may also be an optimal carrier for the controlled drug release formulation without any chemical excipients.
32215793	0	35	theme	enzyme-mediated	15:29	arg1	cellulose					31:39	enzyme-mediated cellulose	15:39	enzyme-mediated cellulose	15:39	Application of enzyme-mediated cellulose nanofibers from lemongrass waste for the controlled release of anticancer drugs.
32215793	4	36	theme	cellulose	559:567	arg1	nanofibers-camptothecin					569:591	cellulose nanofibers-camptothecin	559:591	cellulose nanofibers-camptothecin	559:591	Firstly, the camptothecin was encapsulated into the cellulose nanofiber complex by adjusting the composition ratio of cellulose nanofibers-camptothecin, i.e., 10:3, 10:5, and 10:7.
32215793	9	37	theme	highest	1232:1238	arg1	correlation					1240:1250	The highest correlation	1228:1250	The highest correlation in all pH conditions	1228:1271	The highest correlation in all pH conditions was obtained in Korsmeyer-Peppas with R2 value = 0.93 (pH 1.2), 0.89 (pH 6.8), and 0.97 (pH 7.4), whereas in Higuchi model, R2 value = 0.89 (pH 1.2), 0.91 (pH 6.8), and 0.98 (pH 7.4), suggesting the release of a drug via a diffusion mechanism.
32215793	9	38	theme	drug	1485:1488	arg1	release					1472:1478	the release	1468:1478	the release of a drug	1468:1488	The highest correlation in all pH conditions was obtained in Korsmeyer-Peppas with R2 value = 0.93 (pH 1.2), 0.89 (pH 6.8), and 0.97 (pH 7.4), whereas in Higuchi model, R2 value = 0.89 (pH 1.2), 0.91 (pH 6.8), and 0.98 (pH 7.4), suggesting the release of a drug via a diffusion mechanism.
32215793	10	39	theme	drug	1640:1643	arg1	formulation					1653:1663	the controlled drug release formulation	1625:1663	the controlled drug release formulation without any chemical excipients	1625:1695	Hence, the results established that enzyme-mediated cellulose nanofibers may also be an optimal carrier for the controlled drug release formulation without any chemical excipients.
32215793	6	40	with	binding	753:759	arg1	nanofibers					792:801	cellulose nanofibers	782:801	cellulose nanofibers	782:801	The binding of camptothecin with cellulose nanofibers was confirmed by FT-IR analysis.
32215793	3	41	theme	aqueous	400:406	arg1	solution					408:415	aqueous solution	400:415	aqueous solution	400:415	However, it has certain limitations like instability, low solubility in aqueous solution, and biological fluids.
32215793	5	42	theme	highest	701:707	arg1	efficiency					723:732	the highest encapsulation efficiency	697:732	the highest encapsulation efficiency	697:732	In the 10:3 composition ratio of cellulose nanofibers, camptothecin showed the highest encapsulation efficiency, i.e., 65.28%.
32215793	8	43	theme	drug	1204:1207	arg1	mechanism					1217:1225	the drug release mechanism	1200:1225	the drug release mechanism	1200:1225	Further, the controlled and extended-release profile was observed at different physiological pH, and different kinetics models were used to understand the drug release mechanism.
32215793	3	44	from	fluids	433:438	arg1	solution					408:415	aqueous solution	400:415	aqueous solution	400:415	However, it has certain limitations like instability, low solubility in aqueous solution, and biological fluids.
32215793	1	45	theme	controlled	212:221	arg1	release					223:229	the controlled release	208:229	the controlled release	208:229	In the present study, an application of cellulose nanofibers has been established for the controlled release of an anticancer drug, i.e., camptothecin.
32215793	3	46	theme	low	382:384	arg1	solubility					386:395	low solubility	382:395	low solubility in aqueous solution	382:415	However, it has certain limitations like instability, low solubility in aqueous solution, and biological fluids.
32215793	5	47	theme	encapsulation	709:721	arg1	efficiency					723:732	the highest encapsulation efficiency	697:732	the highest encapsulation efficiency	697:732	In the 10:3 composition ratio of cellulose nanofibers, camptothecin showed the highest encapsulation efficiency, i.e., 65.28%.
32215793	7	48	theme	nanofibers	1037:1046	arg1	homogeneous					975:985	homogeneous	975:985	homogeneous	975:985	Also, the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies demonstrate physical adsorption of camptothecin onto the homogeneous as well as the heterogeneous surface of cellulose nanofibers.
32215793	9	49	theme	diffusion	1496:1504	arg1	mechanism					1506:1514	a diffusion mechanism	1494:1514	a diffusion mechanism	1494:1514	The highest correlation in all pH conditions was obtained in Korsmeyer-Peppas with R2 value = 0.93 (pH 1.2), 0.89 (pH 6.8), and 0.97 (pH 7.4), whereas in Higuchi model, R2 value = 0.89 (pH 1.2), 0.91 (pH 6.8), and 0.98 (pH 7.4), suggesting the release of a drug via a diffusion mechanism.
32215793	8	50	theme	physiological	1128:1140	arg1	pH					1142:1143	different physiological pH	1118:1143	different physiological pH	1118:1143	Further, the controlled and extended-release profile was observed at different physiological pH, and different kinetics models were used to understand the drug release mechanism.
32215793	0	51	theme	lemongrass	57:66	arg1	waste					68:72	lemongrass waste	57:72	lemongrass waste	57:72	Application of enzyme-mediated cellulose nanofibers from lemongrass waste for the controlled release of anticancer drugs.
32215793	5	52	theme	cellulose	655:663	arg1	nanofibers					665:674	cellulose nanofibers	655:674	cellulose nanofibers	655:674	In the 10:3 composition ratio of cellulose nanofibers, camptothecin showed the highest encapsulation efficiency, i.e., 65.28%.
32215793	9	53	theme	pH	1259:1260	arg1	conditions					1262:1271	all pH conditions	1255:1271	all pH conditions	1255:1271	The highest correlation in all pH conditions was obtained in Korsmeyer-Peppas with R2 value = 0.93 (pH 1.2), 0.89 (pH 6.8), and 0.97 (pH 7.4), whereas in Higuchi model, R2 value = 0.89 (pH 1.2), 0.91 (pH 6.8), and 0.98 (pH 7.4), suggesting the release of a drug via a diffusion mechanism.
32215793	10	54	theme	optimal	1605:1611	arg1	nanofibers					1579:1588	enzyme-mediated cellulose nanofibers	1553:1588	enzyme-mediated cellulose nanofibers	1553:1588	Hence, the results established that enzyme-mediated cellulose nanofibers may also be an optimal carrier for the controlled drug release formulation without any chemical excipients.
32215793	10	54	theme	optimal	1605:1611	arg1	carrier					1613:1619	an optimal carrier	1602:1619	an optimal carrier for the controlled drug release formulation without any chemical excipients	1602:1695	Hence, the results established that enzyme-mediated cellulose nanofibers may also be an optimal carrier for the controlled drug release formulation without any chemical excipients.
32215793	5	55	theme	nanofibers	665:674	arg1	ratio					646:650	the 10:3 composition ratio	625:650	the 10:3 composition ratio of cellulose nanofibers	625:674	In the 10:3 composition ratio of cellulose nanofibers, camptothecin showed the highest encapsulation efficiency, i.e., 65.28%.
32215793	6	56	theme	FT-IR	820:824	arg1	analysis					826:833	FT-IR analysis	820:833	FT-IR analysis	820:833	The binding of camptothecin with cellulose nanofibers was confirmed by FT-IR analysis.
32215793	3	57	contain	has	340:342	arg1	it					337:338	it	337:338	it	337:338	However, it has certain limitations like instability, low solubility in aqueous solution, and biological fluids.
32215793	3	57	contain	has	340:342	arg2	limitations					352:362	certain limitations	344:362	certain limitations	344:362	However, it has certain limitations like instability, low solubility in aqueous solution, and biological fluids.
32215793	1	58	theme	present	129:135	arg1	study					137:141	the present study	125:141	the present study	125:141	In the present study, an application of cellulose nanofibers has been established for the controlled release of an anticancer drug, i.e., camptothecin.
32215793	7	59	theme	Dubinin-Radushkevich	880:899	arg1	isotherm					901:908	Dubinin-Radushkevich isotherm	880:908	Dubinin-Radushkevich isotherm	880:908	Also, the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies demonstrate physical adsorption of camptothecin onto the homogeneous as well as the heterogeneous surface of cellulose nanofibers.
32215793	7	60	theme	cellulose	1027:1035	arg1	nanofibers					1037:1046	cellulose nanofibers	1027:1046	cellulose nanofibers	1027:1046	Also, the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies demonstrate physical adsorption of camptothecin onto the homogeneous as well as the heterogeneous surface of cellulose nanofibers.
32215793	7	61	theme	heterogeneous	1002:1014	arg1	surface					1016:1022	the heterogeneous surface	998:1022	the homogeneous as well as the heterogeneous surface of cellulose nanofibers	971:1046	Also, the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies demonstrate physical adsorption of camptothecin onto the homogeneous as well as the heterogeneous surface of cellulose nanofibers.
32215793	2	62	theme	antitumor	308:316	arg1	activity					318:325	its antitumor activity	304:325	its antitumor activity	304:325	The camptothecin is known for its antitumor activity.
32215793	7	63	theme	Temkin	868:873	arg1	studies					910:916	the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies	842:916	the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies	842:916	Also, the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm studies demonstrate physical adsorption of camptothecin onto the homogeneous as well as the heterogeneous surface of cellulose nanofibers.
32215793	8	64	theme	release	1209:1215	arg1	mechanism					1217:1225	the drug release mechanism	1200:1225	the drug release mechanism	1200:1225	Further, the controlled and extended-release profile was observed at different physiological pH, and different kinetics models were used to understand the drug release mechanism.
32215793	4	65	dep	10:3	600:603	arg1	i.e.					594:597	i.e.	594:597	i.e.	594:597	Firstly, the camptothecin was encapsulated into the cellulose nanofiber complex by adjusting the composition ratio of cellulose nanofibers-camptothecin, i.e., 10:3, 10:5, and 10:7.
32215793	8	66	located	observed	1106:1113	arg1	pH					1142:1143	different physiological pH	1118:1143	different physiological pH	1118:1143	Further, the controlled and extended-release profile was observed at different physiological pH, and different kinetics models were used to understand the drug release mechanism.
32215793	8	66	located	observed	1106:1113	arg2	profile					1094:1100	the controlled and extended-release profile	1058:1100	profile	1094:1100	Further, the controlled and extended-release profile was observed at different physiological pH, and different kinetics models were used to understand the drug release mechanism.
32215793	3	67	theme	biological	422:431	arg1	fluids					433:438	biological fluids	422:438	biological fluids	422:438	However, it has certain limitations like instability, low solubility in aqueous solution, and biological fluids.
32215793	10	68	theme	enzyme-mediated	1553:1567	arg1	nanofibers					1579:1588	enzyme-mediated cellulose nanofibers	1553:1588	enzyme-mediated cellulose nanofibers	1553:1588	Hence, the results established that enzyme-mediated cellulose nanofibers may also be an optimal carrier for the controlled drug release formulation without any chemical excipients.
32215793	10	68	theme	enzyme-mediated	1553:1567	arg1	carrier					1613:1619	an optimal carrier	1602:1619	an optimal carrier for the controlled drug release formulation without any chemical excipients	1602:1695	Hence, the results established that enzyme-mediated cellulose nanofibers may also be an optimal carrier for the controlled drug release formulation without any chemical excipients.
32215793	10	69	theme	controlled	1629:1638	arg1	formulation					1653:1663	the controlled drug release formulation	1625:1663	the controlled drug release formulation without any chemical excipients	1625:1695	Hence, the results established that enzyme-mediated cellulose nanofibers may also be an optimal carrier for the controlled drug release formulation without any chemical excipients.
32215793	1	70	theme	anticancer	237:246	arg1	drug					248:251	an anticancer drug	234:251	an anticancer drug	234:251	In the present study, an application of cellulose nanofibers has been established for the controlled release of an anticancer drug, i.e., camptothecin.
32174534	7	0	theme	production	1185:1194	arg1	rate					1196:1199	the higher sludge production rate	1167:1199	the higher sludge production rate in activated sludge systems	1167:1227	However, the lower ALE content in flocs may be compensated by the higher sludge production rate in activated sludge systems.
32174534	2	1	theme	ALE	341:343	arg1	WWTP					405:408	WWTP	405:408	WWTP	405:408	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP) is a relevant approach for the recovery of valuable products of industrial interest.
32174534	2	1	theme	ALE	341:343	arg1	plants					397:402	ALE from excess sludge produced by wastewater treatment plants	341:402	ALE from excess sludge produced by wastewater treatment plants (WWTP)	341:409	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP) is a relevant approach for the recovery of valuable products of industrial interest.
32174534	7	2	from	rate	1196:1199	arg1	systems					1221:1227	activated sludge systems	1204:1227	activated sludge systems	1204:1227	However, the lower ALE content in flocs may be compensated by the higher sludge production rate in activated sludge systems.
32174534	8	3	theme	nutrient	1322:1329	arg1	conversion					1353:1362	the nutrient and organic substrate conversion	1318:1362	the nutrient and organic substrate conversion	1318:1362	Principal component analysis (PCA) revealed that ALE content positively correlates with the nutrient and organic substrate conversion, and with the fraction of large AGS.
32174534	1	4	theme	sludge	279:284	arg1	EPS					260:262	EPS	260:262	EPS	260:262	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	4	theme	sludge	279:284	arg1	substances					248:257	the extracellular polymeric substances	220:257	the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS)	220:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	4	theme	sludge	279:284	arg1	sludge					311:316	aerobic granular sludge	294:316	aerobic granular sludge (AGS)	294:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	11	5	theme	sludge	1846:1851	arg1	valorization					1853:1864	waste biological sludge valorization	1829:1864	waste biological sludge valorization	1829:1864	Therefore, our study provides insights about quantitative and qualitative aspects of ALE which are helpful for the improvement of waste biological sludge valorization.
32174534	3	6	theme	content	543:549	arg1	dynamics					527:534	dynamics	527:534	dynamics of ALE content in sludge and associated factors	527:582	However, little is known about dynamics of ALE content in sludge and associated factors.
32174534	9	7	theme	Microbial	1401:1409	arg1	analyses					1411:1418	Microbial analyses	1401:1418	Microbial analyses	1401:1418	Microbial analyses indicated that a stable microbial community composition was associated with a higher and more stable ALE content.
32174534	0	8	theme	municipal	127:135	arg1	wastewater					137:146	municipal wastewater	127:146	municipal wastewater	127:146	Biopolymers recovery: dynamics and characterization of alginate-like exopolymers in an aerobic granular sludge system treating municipal wastewater without sludge inoculum.
32174534	8	9	theme	large	1390:1394	arg1	AGS					1396:1398	large AGS	1390:1398	large AGS	1390:1398	Principal component analysis (PCA) revealed that ALE content positively correlates with the nutrient and organic substrate conversion, and with the fraction of large AGS.
32174534	8	10	theme	Principal	1230:1238	arg1	PCA					1260:1262	PCA	1260:1262	PCA	1260:1262	Principal component analysis (PCA) revealed that ALE content positively correlates with the nutrient and organic substrate conversion, and with the fraction of large AGS.
32174534	8	10	theme	Principal	1230:1238	arg1	analysis					1250:1257	Principal component analysis	1230:1257	Principal component analysis (PCA)	1230:1263	Principal component analysis (PCA) revealed that ALE content positively correlates with the nutrient and organic substrate conversion, and with the fraction of large AGS.
32174534	11	11	theme	ALE	1784:1786	arg1	aspects					1773:1779	quantitative and qualitative aspects	1744:1779	quantitative and qualitative aspects of ALE	1744:1786	Therefore, our study provides insights about quantitative and qualitative aspects of ALE which are helpful for the improvement of waste biological sludge valorization.
32174534	3	12	theme	associated	565:574	arg1	factors					576:582	sludge and associated factors	554:582	sludge and associated factors	554:582	However, little is known about dynamics of ALE content in sludge and associated factors.
32174534	1	13	theme	extracellular	224:236	arg1	EPS					260:262	EPS	260:262	EPS	260:262	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	13	theme	extracellular	224:236	arg1	substances					248:257	the extracellular polymeric substances	220:257	the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS)	220:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	13	theme	extracellular	224:236	arg1	sludge					311:316	aerobic granular sludge	294:316	aerobic granular sludge (AGS)	294:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	5	14	dep	higher	925:930	arg1	stable					938:943	stable	938:943	stable	938:943	Results indicated that the EPS content was not correlated with the development of AGS, while the ALE content was higher, more stable and steadily increased after granulation achievement.
32174534	3	15	theme	sludge	554:559	arg1	factors					576:582	sludge and associated factors	554:582	sludge and associated factors	554:582	However, little is known about dynamics of ALE content in sludge and associated factors.
32174534	4	16	from	reactor	773:779	arg1	ALE					645:647	ALE	645:647	ALE	645:647	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	9	17	theme	microbial	1444:1452	arg1	composition					1464:1474	a stable microbial community composition	1435:1474	a stable microbial community composition	1435:1474	Microbial analyses indicated that a stable microbial community composition was associated with a higher and more stable ALE content.
32174534	1	18	from	substances	248:257	arg1	present					209:215	present	209:215	present	209:215	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	5	19	theme	AGS	894:896	arg1	development					879:889	the development	875:889	the development of AGS	875:896	Results indicated that the EPS content was not correlated with the development of AGS, while the ALE content was higher, more stable and steadily increased after granulation achievement.
32174534	2	20	theme	industrial	475:484	arg1	interest					486:493	industrial interest	475:493	industrial interest	475:493	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP) is a relevant approach for the recovery of valuable products of industrial interest.
32174534	3	21	from	content	543:549	arg1	factors					576:582	sludge and associated factors	554:582	sludge and associated factors	554:582	However, little is known about dynamics of ALE content in sludge and associated factors.
32174534	7	22	theme	sludge	1178:1183	arg1	rate					1196:1199	the higher sludge production rate	1167:1199	the higher sludge production rate in activated sludge systems	1167:1227	However, the lower ALE content in flocs may be compensated by the higher sludge production rate in activated sludge systems.
32174534	2	23	theme	products	463:470	arg1	recovery					442:449	the recovery	438:449	the recovery of valuable products of industrial interest	438:493	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP) is a relevant approach for the recovery of valuable products of industrial interest.
32174534	8	24	theme	ALE	1279:1281	arg1	content					1283:1289	ALE content	1279:1289	ALE content	1279:1289	Principal component analysis (PCA) revealed that ALE content positively correlates with the nutrient and organic substrate conversion, and with the fraction of large AGS.
32174534	4	25	theme	environmental	711:723	arg1	content					661:667	content	661:667	content	661:667	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	4	25	theme	environmental	711:723	arg1	factors					725:731	influencing environmental factors	699:731	influencing environmental factors	699:731	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	0	26	theme	granular	95:102	arg1	system					111:116	an aerobic granular sludge system	84:116	an aerobic granular sludge system	84:116	Biopolymers recovery: dynamics and characterization of alginate-like exopolymers in an aerobic granular sludge system treating municipal wastewater without sludge inoculum.
32174534	9	27	theme	stable	1514:1519	arg1	content					1525:1531	a higher and more stable ALE content	1496:1531	a higher and more stable ALE content	1496:1531	Microbial analyses indicated that a stable microbial community composition was associated with a higher and more stable ALE content.
32174534	1	28	from	present	209:215	arg1	EPS					260:262	EPS	260:262	EPS	260:262	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	28	from	present	209:215	arg1	substances					248:257	the extracellular polymeric substances	220:257	the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS)	220:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	28	from	present	209:215	arg1	sludge					311:316	aerobic granular sludge	294:316	aerobic granular sludge (AGS)	294:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	4	29	theme	chemical	675:682	arg1	properties					684:693	some chemical properties	670:693	some chemical properties	670:693	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	4	29	theme	chemical	675:682	arg1	content					661:667	content	661:667	content	661:667	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	10	30	theme	hydrogel	1589:1596	arg1	property					1598:1605	hydrogel property	1589:1605	hydrogel property	1589:1605	ALE recovered from both flocs and AGS was endowed with hydrogel property, and no clear difference in their elemental composition and functional groups was observed.
32174534	6	31	theme	VSALE/g	1020:1026	arg1	VSsludge					1028:1035	236 ± 27 mg VSALE/g VSsludge	1008:1035	236 ± 27 mg VSALE/g VSsludge	1008:1035	Overall, 236 ± 27 mg VSALE/g VSsludge was recovered from AGS and 187 ± 94 mg VSALE/g VSsludge from flocs.
32174534	8	32	theme	organic	1335:1341	arg1	conversion					1353:1362	the nutrient and organic substrate conversion	1318:1362	the nutrient and organic substrate conversion	1318:1362	Principal component analysis (PCA) revealed that ALE content positively correlates with the nutrient and organic substrate conversion, and with the fraction of large AGS.
32174534	7	33	theme	ALE	1124:1126	arg1	content					1128:1134	the lower ALE content	1114:1134	the lower ALE content in flocs	1114:1143	However, the lower ALE content in flocs may be compensated by the higher sludge production rate in activated sludge systems.
32174534	1	34	theme	aerobic	294:300	arg1	AGS					319:321	AGS	319:321	AGS	319:321	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	34	theme	aerobic	294:300	arg1	sludge					311:316	aerobic granular sludge	294:316	aerobic granular sludge (AGS)	294:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	5	35	theme	ALE	909:911	arg1	higher					925:930	higher	925:930	higher	925:930	Results indicated that the EPS content was not correlated with the development of AGS, while the ALE content was higher, more stable and steadily increased after granulation achievement.
32174534	5	35	theme	ALE	909:911	arg1	content					913:919	the ALE content	905:919	the ALE content	905:919	Results indicated that the EPS content was not correlated with the development of AGS, while the ALE content was higher, more stable and steadily increased after granulation achievement.
32174534	0	36	theme	exopolymers	69:79	arg1	characterization					35:50	characterization	35:50	characterization	35:50	Biopolymers recovery: dynamics and characterization of alginate-like exopolymers in an aerobic granular sludge system treating municipal wastewater without sludge inoculum.
32174534	0	36	theme	exopolymers	69:79	arg1	dynamics					22:29	dynamics	22:29	dynamics	22:29	Biopolymers recovery: dynamics and characterization of alginate-like exopolymers in an aerobic granular sludge system treating municipal wastewater without sludge inoculum.
32174534	4	37	theme	municipal	790:798	arg1	wastewater					800:809	municipal wastewater	790:809	municipal wastewater	790:809	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	1	38	attach	present	209:215	arg2	exopolymers					187:197	Alginate-like exopolymers	173:197	Alginate-like exopolymers (ALE)	173:203	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	38	attach	present	209:215	arg1	EPS					260:262	EPS	260:262	EPS	260:262	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	38	attach	present	209:215	arg1	substances					248:257	the extracellular polymeric substances	220:257	the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS)	220:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	38	attach	present	209:215	arg1	sludge					311:316	aerobic granular sludge	294:316	aerobic granular sludge (AGS)	294:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	4	39	theme	batch	767:771	arg1	reactor					773:779	a sequencing batch reactor	754:779	a sequencing batch reactor treating municipal wastewater	754:809	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	1	40	theme	polymeric	238:246	arg1	EPS					260:262	EPS	260:262	EPS	260:262	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	40	theme	polymeric	238:246	arg1	substances					248:257	the extracellular polymeric substances	220:257	the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS)	220:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	40	theme	polymeric	238:246	arg1	sludge					311:316	aerobic granular sludge	294:316	aerobic granular sludge (AGS)	294:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	6	41	theme	VSALE/g	1076:1082	arg1	VSsludge					1084:1091	187 ± 94 mg VSALE/g VSsludge	1064:1091	187 ± 94 mg VSALE/g VSsludge	1064:1091	Overall, 236 ± 27 mg VSALE/g VSsludge was recovered from AGS and 187 ± 94 mg VSALE/g VSsludge from flocs.
32174534	4	42	theme	sequencing	756:765	arg1	reactor					773:779	a sequencing batch reactor	754:779	a sequencing batch reactor treating municipal wastewater	754:809	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	11	43	theme	waste	1829:1833	arg1	valorization					1853:1864	waste biological sludge valorization	1829:1864	waste biological sludge valorization	1829:1864	Therefore, our study provides insights about quantitative and qualitative aspects of ALE which are helpful for the improvement of waste biological sludge valorization.
32174534	4	44	from	terms	652:656	arg1	ALE					645:647	ALE	645:647	ALE	645:647	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	10	45	from	difference	1621:1630	arg1	composition					1651:1661	their elemental composition	1635:1661	their elemental composition	1635:1661	ALE recovered from both flocs and AGS was endowed with hydrogel property, and no clear difference in their elemental composition and functional groups was observed.
32174534	10	45	from	difference	1621:1630	arg1	groups					1678:1683	functional groups	1667:1683	functional groups	1667:1683	ALE recovered from both flocs and AGS was endowed with hydrogel property, and no clear difference in their elemental composition and functional groups was observed.
32174534	7	46	theme	activated	1204:1212	arg1	systems					1221:1227	activated sludge systems	1204:1227	activated sludge systems	1204:1227	However, the lower ALE content in flocs may be compensated by the higher sludge production rate in activated sludge systems.
32174534	10	47	theme	functional	1667:1676	arg1	groups					1678:1683	functional groups	1667:1683	functional groups	1667:1683	ALE recovered from both flocs and AGS was endowed with hydrogel property, and no clear difference in their elemental composition and functional groups was observed.
32174534	4	48	from	ALE	645:647	arg1	reactor					773:779	a sequencing batch reactor	754:779	a sequencing batch reactor treating municipal wastewater	754:809	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	4	48	from	ALE	645:647	arg1	terms					652:656	terms	652:656	terms of content, some chemical properties and influencing environmental factors	652:731	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	1	49	theme	biological	268:277	arg1	sludge					279:284	biological sludge	268:284	biological sludge	268:284	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	3	50	theme	ALE	539:541	arg1	content					543:549	ALE content	539:549	ALE content in sludge and associated factors	539:582	However, little is known about dynamics of ALE content in sludge and associated factors.
32174534	5	51	theme	EPS	839:841	arg1	content					843:849	the EPS content	835:849	the EPS content	835:849	Results indicated that the EPS content was not correlated with the development of AGS, while the ALE content was higher, more stable and steadily increased after granulation achievement.
32174534	2	52	from	sludge	357:362	arg1	ALE					341:343	ALE	341:343	ALE	341:343	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP) is a relevant approach for the recovery of valuable products of industrial interest.
32174534	11	53	theme	qualitative	1761:1771	arg1	aspects					1773:1779	quantitative and qualitative aspects	1744:1779	quantitative and qualitative aspects of ALE	1744:1786	Therefore, our study provides insights about quantitative and qualitative aspects of ALE which are helpful for the improvement of waste biological sludge valorization.
32174534	8	54	theme	AGS	1396:1398	arg1	fraction					1378:1385	the fraction	1374:1385	the fraction of large AGS	1374:1398	Principal component analysis (PCA) revealed that ALE content positively correlates with the nutrient and organic substrate conversion, and with the fraction of large AGS.
32174534	11	55	theme	quantitative	1744:1755	arg1	aspects					1773:1779	quantitative and qualitative aspects	1744:1779	quantitative and qualitative aspects of ALE	1744:1786	Therefore, our study provides insights about quantitative and qualitative aspects of ALE which are helpful for the improvement of waste biological sludge valorization.
32174534	0	56	theme	sludge	156:161	arg1	inoculum					163:170	sludge inoculum	156:170	sludge inoculum	156:170	Biopolymers recovery: dynamics and characterization of alginate-like exopolymers in an aerobic granular sludge system treating municipal wastewater without sludge inoculum.
32174534	9	57	theme	stable	1437:1442	arg1	composition					1464:1474	a stable microbial community composition	1435:1474	a stable microbial community composition	1435:1474	Microbial analyses indicated that a stable microbial community composition was associated with a higher and more stable ALE content.
32174534	8	58	theme	component	1240:1248	arg1	PCA					1260:1262	PCA	1260:1262	PCA	1260:1262	Principal component analysis (PCA) revealed that ALE content positively correlates with the nutrient and organic substrate conversion, and with the fraction of large AGS.
32174534	8	58	theme	component	1240:1248	arg1	analysis					1250:1257	Principal component analysis	1230:1257	Principal component analysis (PCA)	1230:1263	Principal component analysis (PCA) revealed that ALE content positively correlates with the nutrient and organic substrate conversion, and with the fraction of large AGS.
32174534	3	59	from	dynamics	527:534	arg1	factors					576:582	sludge and associated factors	554:582	sludge and associated factors	554:582	However, little is known about dynamics of ALE content in sludge and associated factors.
32174534	1	60	located	present	209:215	arg2	exopolymers					187:197	Alginate-like exopolymers	173:197	Alginate-like exopolymers (ALE)	173:203	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	60	located	present	209:215	arg1	EPS					260:262	EPS	260:262	EPS	260:262	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	60	located	present	209:215	arg1	substances					248:257	the extracellular polymeric substances	220:257	the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS)	220:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	60	located	present	209:215	arg1	sludge					311:316	aerobic granular sludge	294:316	aerobic granular sludge (AGS)	294:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	9	61	theme	community	1454:1462	arg1	composition					1464:1474	a stable microbial community composition	1435:1474	a stable microbial community composition	1435:1474	Microbial analyses indicated that a stable microbial community composition was associated with a higher and more stable ALE content.
32174534	4	62	theme	content	661:667	arg1	terms					652:656	terms	652:656	terms of content, some chemical properties and influencing environmental factors	652:731	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	7	63	theme	higher	1171:1176	arg1	rate					1196:1199	the higher sludge production rate	1167:1199	the higher sludge production rate in activated sludge systems	1167:1227	However, the lower ALE content in flocs may be compensated by the higher sludge production rate in activated sludge systems.
32174534	0	64	from	dynamics	22:29	arg1	system					111:116	an aerobic granular sludge system	84:116	an aerobic granular sludge system	84:116	Biopolymers recovery: dynamics and characterization of alginate-like exopolymers in an aerobic granular sludge system treating municipal wastewater without sludge inoculum.
32174534	4	65	theme	EPS	637:639	arg1	dynamics					625:632	the dynamics	621:632	the dynamics of EPS	621:639	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	0	66	theme	aerobic	87:93	arg1	system					111:116	an aerobic granular sludge system	84:116	an aerobic granular sludge system	84:116	Biopolymers recovery: dynamics and characterization of alginate-like exopolymers in an aerobic granular sludge system treating municipal wastewater without sludge inoculum.
32174534	1	67	theme	Alginate-like	173:185	arg1	exopolymers					187:197	Alginate-like exopolymers	173:197	Alginate-like exopolymers (ALE)	173:203	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	2	68	theme	valuable	454:461	arg1	products					463:470	valuable products	454:470	valuable products of industrial interest	454:493	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP) is a relevant approach for the recovery of valuable products of industrial interest.
32174534	0	69	theme	sludge	104:109	arg1	system					111:116	an aerobic granular sludge system	84:116	an aerobic granular sludge system	84:116	Biopolymers recovery: dynamics and characterization of alginate-like exopolymers in an aerobic granular sludge system treating municipal wastewater without sludge inoculum.
32174534	9	70	theme	higher	1498:1503	arg1	content					1525:1531	a higher and more stable ALE content	1496:1531	a higher and more stable ALE content	1496:1531	Microbial analyses indicated that a stable microbial community composition was associated with a higher and more stable ALE content.
32174534	4	71	theme	influencing	699:709	arg1	content					661:667	content	661:667	content	661:667	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	4	71	theme	influencing	699:709	arg1	factors					725:731	influencing environmental factors	699:731	influencing environmental factors	699:731	Thus, this study aimed at assessing the dynamics of EPS and ALE in terms of content, some chemical properties and influencing environmental factors along granulation in a sequencing batch reactor treating municipal wastewater.
32174534	3	72	from	factors	576:582	arg1	dynamics					527:534	dynamics	527:534	dynamics of ALE content in sludge and associated factors	527:582	However, little is known about dynamics of ALE content in sludge and associated factors.
32174534	2	73	theme	interest	486:493	arg1	products					463:470	valuable products	454:470	valuable products of industrial interest	454:493	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP) is a relevant approach for the recovery of valuable products of industrial interest.
32174534	0	74	from	characterization	35:50	arg1	system					111:116	an aerobic granular sludge system	84:116	an aerobic granular sludge system	84:116	Biopolymers recovery: dynamics and characterization of alginate-like exopolymers in an aerobic granular sludge system treating municipal wastewater without sludge inoculum.
32174534	2	75	theme	wastewater	376:385	arg1	treatment					387:395	wastewater treatment	376:395	wastewater treatment	376:395	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP) is a relevant approach for the recovery of valuable products of industrial interest.
32174534	9	76	theme	ALE	1521:1523	arg1	content					1525:1531	a higher and more stable ALE content	1496:1531	a higher and more stable ALE content	1496:1531	Microbial analyses indicated that a stable microbial community composition was associated with a higher and more stable ALE content.
32174534	2	77	theme	relevant	416:423	arg1	recovery					329:336	The recovery	325:336	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP)	325:409	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP) is a relevant approach for the recovery of valuable products of industrial interest.
32174534	2	77	theme	relevant	416:423	arg1	approach					425:432	a relevant approach	414:432	a relevant approach for the recovery of valuable products of industrial interest	414:493	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP) is a relevant approach for the recovery of valuable products of industrial interest.
32174534	1	78	dep	exopolymers	187:197	arg1	ALE					200:202	ALE	200:202	ALE	200:202	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	11	79	theme	valorization	1853:1864	arg1	improvement					1814:1824	the improvement	1810:1824	the improvement of waste biological sludge valorization	1810:1864	Therefore, our study provides insights about quantitative and qualitative aspects of ALE which are helpful for the improvement of waste biological sludge valorization.
32174534	6	80	theme	236 ± 27 mg	1008:1018	arg1	VSsludge					1028:1035	236 ± 27 mg VSALE/g VSsludge	1008:1035	236 ± 27 mg VSALE/g VSsludge	1008:1035	Overall, 236 ± 27 mg VSALE/g VSsludge was recovered from AGS and 187 ± 94 mg VSALE/g VSsludge from flocs.
32174534	10	81	theme	clear	1615:1619	arg1	difference					1621:1630	no clear difference	1612:1630	no clear difference in their elemental composition and functional groups	1612:1683	ALE recovered from both flocs and AGS was endowed with hydrogel property, and no clear difference in their elemental composition and functional groups was observed.
32174534	1	82	theme	granular	302:309	arg1	AGS					319:321	AGS	319:321	AGS	319:321	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	1	82	theme	granular	302:309	arg1	sludge					311:316	aerobic granular sludge	294:316	aerobic granular sludge (AGS)	294:322	Alginate-like exopolymers (ALE) are present in the extracellular polymeric substances (EPS) of biological sludge such as aerobic granular sludge (AGS).
32174534	8	83	theme	substrate	1343:1351	arg1	conversion					1353:1362	the nutrient and organic substrate conversion	1318:1362	the nutrient and organic substrate conversion	1318:1362	Principal component analysis (PCA) revealed that ALE content positively correlates with the nutrient and organic substrate conversion, and with the fraction of large AGS.
32174534	2	84	theme	plants	397:402	arg1	recovery					329:336	The recovery	325:336	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP)	325:409	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP) is a relevant approach for the recovery of valuable products of industrial interest.
32174534	2	84	theme	plants	397:402	arg1	approach					425:432	a relevant approach	414:432	a relevant approach for the recovery of valuable products of industrial interest	414:493	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP) is a relevant approach for the recovery of valuable products of industrial interest.
32174534	0	85	theme	alginate-like	55:67	arg1	exopolymers					69:79	alginate-like exopolymers	55:79	alginate-like exopolymers	55:79	Biopolymers recovery: dynamics and characterization of alginate-like exopolymers in an aerobic granular sludge system treating municipal wastewater without sludge inoculum.
32174534	5	86	theme	granulation	974:984	arg1	achievement					986:996	granulation achievement	974:996	granulation achievement	974:996	Results indicated that the EPS content was not correlated with the development of AGS, while the ALE content was higher, more stable and steadily increased after granulation achievement.
32174534	7	87	from	content	1128:1134	arg1	flocs					1139:1143	flocs	1139:1143	flocs	1139:1143	However, the lower ALE content in flocs may be compensated by the higher sludge production rate in activated sludge systems.
32174534	10	88	theme	elemental	1641:1649	arg1	composition					1651:1661	their elemental composition	1635:1661	their elemental composition	1635:1661	ALE recovered from both flocs and AGS was endowed with hydrogel property, and no clear difference in their elemental composition and functional groups was observed.
32174534	7	89	theme	sludge	1214:1219	arg1	systems					1221:1227	activated sludge systems	1204:1227	activated sludge systems	1204:1227	However, the lower ALE content in flocs may be compensated by the higher sludge production rate in activated sludge systems.
32174534	10	90	with	endowed	1576:1582	arg1	property					1598:1605	hydrogel property	1589:1605	hydrogel property	1589:1605	ALE recovered from both flocs and AGS was endowed with hydrogel property, and no clear difference in their elemental composition and functional groups was observed.
32174534	11	91	theme	biological	1835:1844	arg1	valorization					1853:1864	waste biological sludge valorization	1829:1864	waste biological sludge valorization	1829:1864	Therefore, our study provides insights about quantitative and qualitative aspects of ALE which are helpful for the improvement of waste biological sludge valorization.
32174534	0	92	dep	recovery	12:19	arg1	Biopolymers					0:10	Biopolymers	0:10	Biopolymers	0:10	Biopolymers recovery: dynamics and characterization of alginate-like exopolymers in an aerobic granular sludge system treating municipal wastewater without sludge inoculum.
32174534	6	93	theme	187 ± 94 mg	1064:1074	arg1	VSsludge					1084:1091	187 ± 94 mg VSALE/g VSsludge	1064:1091	187 ± 94 mg VSALE/g VSsludge	1064:1091	Overall, 236 ± 27 mg VSALE/g VSsludge was recovered from AGS and 187 ± 94 mg VSALE/g VSsludge from flocs.
32174534	2	94	theme	excess	350:355	arg1	sludge					357:362	excess sludge	350:362	excess sludge produced by wastewater treatment	350:395	The recovery of ALE from excess sludge produced by wastewater treatment plants (WWTP) is a relevant approach for the recovery of valuable products of industrial interest.
32458960	0	0	theme	molecule	83:90	arg1	spectroscopy					98:109	single molecule force spectroscopy	76:109	single molecule force spectroscopy	76:109	Interaction of vascular endothelial growth factor and heparin quantified by single molecule force spectroscopy.
32458960	2	1	theme	angiogenesis-dependent	470:491	arg1	diseases					493:500	many angiogenesis-dependent diseases	465:500	many angiogenesis-dependent diseases including cancer	465:517	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	2	1	theme	angiogenesis-dependent	470:491	arg1	cancer					512:517	cancer	512:517	cancer	512:517	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	3	2	from	step	536:539	arg1	cascade					569:575	the angiogenesis-related cascade	544:575	the angiogenesis-related cascade	544:575	As an important step in the angiogenesis-related cascade, it is necessary to clarify the interaction between VEGF165 (the major form of VEGF-A) and heparin.
32458960	6	3	theme	kinetic	974:980	arg1	Meanwhile					959:967	Meanwhile	959:967	Meanwhile	959:967	Meanwhile, the kinetic and thermodynamic parameters of the VEGF165/heparin complex dissociation process were also obtained.
32458960	6	3	theme	kinetic	974:980	arg1	parameters					1000:1009	the kinetic and thermodynamic parameters	970:1009	the kinetic and thermodynamic parameters of the VEGF165/heparin complex dissociation process	970:1061	Meanwhile, the kinetic and thermodynamic parameters of the VEGF165/heparin complex dissociation process were also obtained.
32458960	0	4	theme	single	76:81	arg1	spectroscopy					98:109	single molecule force spectroscopy	76:109	single molecule force spectroscopy	76:109	Interaction of vascular endothelial growth factor and heparin quantified by single molecule force spectroscopy.
32458960	2	5	dep	pathogenesis	433:444	arg1	the					429:431	the	429:431	the	429:431	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	1	6	theme	exogenous	250:258	arg1	heparin					260:266	exogenous heparin	250:266	exogenous heparin	250:266	Heparin, as an effective anticoagulant, has been increasingly used in clinical practice, but the binding characteristics and influence of exogenous heparin on heparin-affinity proteins in the body are still unclear.
32458960	7	7	theme	simulation	1097:1106	arg1	Results					1083:1089	Results	1083:1089	Results of MD simulation	1083:1106	Results of MD simulation visually displayed the most likely binding conformation of VEGF165/heparin* complex, indicating that hydrogen bonding and hydrophobic interaction play a positive role in the binding between the two molecules.
32458960	4	8	theme	molecule	740:747	arg1	SMFS					769:772	SMFS	769:772	SMFS	769:772	In this work, we investigated this interaction based on single molecule force spectroscopy (SMFS) and molecular dynamics (MD) simulation.
32458960	4	8	theme	molecule	740:747	arg1	spectroscopy					755:766	single molecule force spectroscopy	733:766	single molecule force spectroscopy (SMFS)	733:773	In this work, we investigated this interaction based on single molecule force spectroscopy (SMFS) and molecular dynamics (MD) simulation.
32458960	1	9	theme	heparin	260:266	arg1	influence					237:245	influence	237:245	influence of exogenous heparin on heparin-affinity proteins in the body	237:307	Heparin, as an effective anticoagulant, has been increasingly used in clinical practice, but the binding characteristics and influence of exogenous heparin on heparin-affinity proteins in the body are still unclear.
32458960	1	9	theme	heparin	260:266	arg1	characteristics					217:231	the binding characteristics	205:231	the binding characteristics	205:231	Heparin, as an effective anticoagulant, has been increasingly used in clinical practice, but the binding characteristics and influence of exogenous heparin on heparin-affinity proteins in the body are still unclear.
32458960	1	9	theme	heparin	260:266	arg1	unclear					319:325	unclear	319:325	unclear	319:325	Heparin, as an effective anticoagulant, has been increasingly used in clinical practice, but the binding characteristics and influence of exogenous heparin on heparin-affinity proteins in the body are still unclear.
32458960	0	10	theme	force	92:96	arg1	spectroscopy					98:109	single molecule force spectroscopy	76:109	single molecule force spectroscopy	76:109	Interaction of vascular endothelial growth factor and heparin quantified by single molecule force spectroscopy.
32458960	2	11	with	protein	387:393	arg1	affinity					408:415	heparin affinity	400:415	heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer	400:517	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	4	12	theme	single	733:738	arg1	SMFS					769:772	SMFS	769:772	SMFS	769:772	In this work, we investigated this interaction based on single molecule force spectroscopy (SMFS) and molecular dynamics (MD) simulation.
32458960	4	12	theme	single	733:738	arg1	spectroscopy					755:766	single molecule force spectroscopy	733:766	single molecule force spectroscopy (SMFS)	733:773	In this work, we investigated this interaction based on single molecule force spectroscopy (SMFS) and molecular dynamics (MD) simulation.
32458960	2	13	dep	factor	356:361	arg1	A					363:363	A	363:363	Vascular endothelial growth factor A (VEGF-A)	328:372	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	2	13	dep	factor	356:361	arg1	VEGF-A					366:371	VEGF-A	366:371	VEGF-A	366:371	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	5	14	theme	different	882:890	arg1	rates					900:904	different loading rates	882:904	different loading rates	882:904	From the SMFS study, binding forces between VEGF165 and heparin at different loading rates were quantified under near-physiological conditions.
32458960	7	15	theme	positive	1261:1268	arg1	role					1270:1273	a positive role	1259:1273	a positive role	1259:1273	Results of MD simulation visually displayed the most likely binding conformation of VEGF165/heparin* complex, indicating that hydrogen bonding and hydrophobic interaction play a positive role in the binding between the two molecules.
32458960	3	16	theme	important	526:534	arg1	step					536:539	an important step	523:539	an important step in the angiogenesis-related cascade	523:575	As an important step in the angiogenesis-related cascade, it is necessary to clarify the interaction between VEGF165 (the major form of VEGF-A) and heparin.
32458960	7	17	theme	binding	1143:1149	arg1	conformation					1151:1162	the most likely binding conformation	1127:1162	the most likely binding conformation of VEGF165/heparin* complex	1127:1190	Results of MD simulation visually displayed the most likely binding conformation of VEGF165/heparin* complex, indicating that hydrogen bonding and hydrophobic interaction play a positive role in the binding between the two molecules.
32458960	4	18	theme	force	749:753	arg1	SMFS					769:772	SMFS	769:772	SMFS	769:772	In this work, we investigated this interaction based on single molecule force spectroscopy (SMFS) and molecular dynamics (MD) simulation.
32458960	4	18	theme	force	749:753	arg1	spectroscopy					755:766	single molecule force spectroscopy	733:766	single molecule force spectroscopy (SMFS)	733:773	In this work, we investigated this interaction based on single molecule force spectroscopy (SMFS) and molecular dynamics (MD) simulation.
32458960	5	19	theme	SMFS	824:827	arg1	study					829:833	the SMFS study	820:833	the SMFS study	820:833	From the SMFS study, binding forces between VEGF165 and heparin at different loading rates were quantified under near-physiological conditions.
32458960	7	20	theme	*	1182:1182	arg1	complex					1184:1190	VEGF165/heparin* complex	1167:1190	VEGF165/heparin* complex	1167:1190	Results of MD simulation visually displayed the most likely binding conformation of VEGF165/heparin* complex, indicating that hydrogen bonding and hydrophobic interaction play a positive role in the binding between the two molecules.
32458960	2	21	theme	many	465:468	arg1	diseases					493:500	many angiogenesis-dependent diseases	465:500	many angiogenesis-dependent diseases including cancer	465:517	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	2	21	theme	many	465:468	arg1	cancer					512:517	cancer	512:517	cancer	512:517	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	5	22	theme	loading	892:898	arg1	rates					900:904	different loading rates	882:904	different loading rates	882:904	From the SMFS study, binding forces between VEGF165 and heparin at different loading rates were quantified under near-physiological conditions.
32458960	7	23	theme	complex	1184:1190	arg1	conformation					1151:1162	the most likely binding conformation	1127:1162	the most likely binding conformation of VEGF165/heparin* complex	1127:1190	Results of MD simulation visually displayed the most likely binding conformation of VEGF165/heparin* complex, indicating that hydrogen bonding and hydrophobic interaction play a positive role in the binding between the two molecules.
32458960	1	24	theme	heparin-affinity	271:286	arg1	proteins					288:295	heparin-affinity proteins	271:295	heparin-affinity proteins in the body	271:307	Heparin, as an effective anticoagulant, has been increasingly used in clinical practice, but the binding characteristics and influence of exogenous heparin on heparin-affinity proteins in the body are still unclear.
32458960	1	25	from	proteins	288:295	arg1	body					304:307	the body	300:307	the body	300:307	Heparin, as an effective anticoagulant, has been increasingly used in clinical practice, but the binding characteristics and influence of exogenous heparin on heparin-affinity proteins in the body are still unclear.
32458960	1	26	theme	clinical	182:189	arg1	practice					191:198	clinical practice	182:198	clinical practice	182:198	Heparin, as an effective anticoagulant, has been increasingly used in clinical practice, but the binding characteristics and influence of exogenous heparin on heparin-affinity proteins in the body are still unclear.
32458960	0	27	theme	endothelial	24:34	arg1	factor					43:48	vascular endothelial growth factor	15:48	vascular endothelial growth factor	15:48	Interaction of vascular endothelial growth factor and heparin quantified by single molecule force spectroscopy.
32458960	8	28	theme	safe	1541:1544	arg1	application					1546:1556	the safe application	1537:1556	the safe application of heparin in the clinic	1537:1581	This work provides a new insight into the binding between VEGF165 and heparin and offers a research framework to study the interaction between heparin and multiple heparin affinity proteins, which is helpful for guiding the safe application of heparin in the clinic.
32458960	3	29	theme	angiogenesis-related	548:567	arg1	cascade					569:575	the angiogenesis-related cascade	544:575	the angiogenesis-related cascade	544:575	As an important step in the angiogenesis-related cascade, it is necessary to clarify the interaction between VEGF165 (the major form of VEGF-A) and heparin.
32458960	2	30	theme	heparin	400:406	arg1	affinity					408:415	heparin affinity	400:415	heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer	400:517	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	0	31	theme	vascular	15:22	arg1	factor					43:48	vascular endothelial growth factor	15:48	vascular endothelial growth factor	15:48	Interaction of vascular endothelial growth factor and heparin quantified by single molecule force spectroscopy.
32458960	8	32	theme	heparin	1561:1567	arg1	application					1546:1556	the safe application	1537:1556	the safe application of heparin in the clinic	1537:1581	This work provides a new insight into the binding between VEGF165 and heparin and offers a research framework to study the interaction between heparin and multiple heparin affinity proteins, which is helpful for guiding the safe application of heparin in the clinic.
32458960	3	33	theme	major	642:646	arg1	form					648:651	the major form	638:651	the major form of VEGF-A	638:661	As an important step in the angiogenesis-related cascade, it is necessary to clarify the interaction between VEGF165 (the major form of VEGF-A) and heparin.
32458960	6	34	theme	complex	1034:1040	arg1	process					1055:1061	the VEGF165/heparin complex dissociation process	1014:1061	the VEGF165/heparin complex dissociation process	1014:1061	Meanwhile, the kinetic and thermodynamic parameters of the VEGF165/heparin complex dissociation process were also obtained.
32458960	0	35	theme	factor	43:48	arg1	Interaction					0:10	Interaction	0:10	Interaction of vascular endothelial growth factor and heparin	0:60	Interaction of vascular endothelial growth factor and heparin quantified by single molecule force spectroscopy.
32458960	6	36	theme	VEGF165/heparin	1018:1032	arg1	process					1055:1061	the VEGF165/heparin complex dissociation process	1014:1061	the VEGF165/heparin complex dissociation process	1014:1061	Meanwhile, the kinetic and thermodynamic parameters of the VEGF165/heparin complex dissociation process were also obtained.
32458960	4	37	theme	dynamics	789:796	arg1	simulation					803:812	molecular dynamics (MD) simulation	779:812	molecular dynamics (MD) simulation	779:812	In this work, we investigated this interaction based on single molecule force spectroscopy (SMFS) and molecular dynamics (MD) simulation.
32458960	6	38	theme	process	1055:1061	arg1	Meanwhile					959:967	Meanwhile	959:967	Meanwhile	959:967	Meanwhile, the kinetic and thermodynamic parameters of the VEGF165/heparin complex dissociation process were also obtained.
32458960	6	38	theme	process	1055:1061	arg1	parameters					1000:1009	the kinetic and thermodynamic parameters	970:1009	the kinetic and thermodynamic parameters of the VEGF165/heparin complex dissociation process	970:1061	Meanwhile, the kinetic and thermodynamic parameters of the VEGF165/heparin complex dissociation process were also obtained.
32458960	2	39	theme	protein	387:393	arg1	kind					379:382	a kind	377:382	a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer	377:517	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	2	39	theme	protein	387:393	arg1	factor					356:361	Vascular endothelial growth factor A (VEGF-A)	328:372	Vascular endothelial growth factor A (VEGF-A)	328:372	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	0	40	theme	growth	36:41	arg1	factor					43:48	vascular endothelial growth factor	15:48	vascular endothelial growth factor	15:48	Interaction of vascular endothelial growth factor and heparin quantified by single molecule force spectroscopy.
32458960	8	41	dep	heparin	1460:1466	arg1	proteins					1498:1505	affinity proteins	1489:1505	affinity proteins	1489:1505	This work provides a new insight into the binding between VEGF165 and heparin and offers a research framework to study the interaction between heparin and multiple heparin affinity proteins, which is helpful for guiding the safe application of heparin in the clinic.
32458960	4	42	theme	molecular	779:787	arg1	dynamics					789:796	molecular dynamics	779:796	molecular dynamics (MD) simulation	779:812	In this work, we investigated this interaction based on single molecule force spectroscopy (SMFS) and molecular dynamics (MD) simulation.
32458960	4	42	theme	molecular	779:787	arg1	MD					799:800	MD	799:800	MD	799:800	In this work, we investigated this interaction based on single molecule force spectroscopy (SMFS) and molecular dynamics (MD) simulation.
32458960	3	43	dep	VEGF165	629:635	arg1	form					648:651	the major form	638:651	the major form of VEGF-A	638:661	As an important step in the angiogenesis-related cascade, it is necessary to clarify the interaction between VEGF165 (the major form of VEGF-A) and heparin.
32458960	0	44	theme	heparin	54:60	arg1	Interaction					0:10	Interaction	0:10	Interaction of vascular endothelial growth factor and heparin	0:60	Interaction of vascular endothelial growth factor and heparin quantified by single molecule force spectroscopy.
32458960	5	45	theme	near-physiological	928:945	arg1	conditions					947:956	near-physiological conditions	928:956	near-physiological conditions	928:956	From the SMFS study, binding forces between VEGF165 and heparin at different loading rates were quantified under near-physiological conditions.
32458960	2	46	theme	growth	349:354	arg1	kind					379:382	a kind	377:382	a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer	377:517	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	2	46	theme	growth	349:354	arg1	factor					356:361	Vascular endothelial growth factor A (VEGF-A)	328:372	Vascular endothelial growth factor A (VEGF-A)	328:372	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	7	47	theme	likely	1136:1141	arg1	conformation					1151:1162	the most likely binding conformation	1127:1162	the most likely binding conformation of VEGF165/heparin* complex	1127:1190	Results of MD simulation visually displayed the most likely binding conformation of VEGF165/heparin* complex, indicating that hydrogen bonding and hydrophobic interaction play a positive role in the binding between the two molecules.
32458960	1	48	from	influence	237:245	arg1	proteins					288:295	heparin-affinity proteins	271:295	heparin-affinity proteins in the body	271:307	Heparin, as an effective anticoagulant, has been increasingly used in clinical practice, but the binding characteristics and influence of exogenous heparin on heparin-affinity proteins in the body are still unclear.
32458960	8	49	theme	multiple	1472:1479	arg1	heparin					1481:1487	multiple heparin	1472:1487	multiple heparin	1472:1487	This work provides a new insight into the binding between VEGF165 and heparin and offers a research framework to study the interaction between heparin and multiple heparin affinity proteins, which is helpful for guiding the safe application of heparin in the clinic.
32458960	7	50	theme	MD	1094:1095	arg1	simulation					1097:1106	MD simulation	1094:1106	MD simulation	1094:1106	Results of MD simulation visually displayed the most likely binding conformation of VEGF165/heparin* complex, indicating that hydrogen bonding and hydrophobic interaction play a positive role in the binding between the two molecules.
32458960	2	51	theme	endothelial	337:347	arg1	kind					379:382	a kind	377:382	a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer	377:517	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	2	51	theme	endothelial	337:347	arg1	factor					356:361	Vascular endothelial growth factor A (VEGF-A)	328:372	Vascular endothelial growth factor A (VEGF-A)	328:372	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	2	52	theme	Vascular	328:335	arg1	kind					379:382	a kind	377:382	a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer	377:517	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	2	52	theme	Vascular	328:335	arg1	factor					356:361	Vascular endothelial growth factor A (VEGF-A)	328:372	Vascular endothelial growth factor A (VEGF-A)	328:372	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	1	53	theme	binding	209:215	arg1	characteristics					217:231	the binding characteristics	205:231	the binding characteristics	205:231	Heparin, as an effective anticoagulant, has been increasingly used in clinical practice, but the binding characteristics and influence of exogenous heparin on heparin-affinity proteins in the body are still unclear.
32458960	1	53	theme	binding	209:215	arg1	unclear					319:325	unclear	319:325	unclear	319:325	Heparin, as an effective anticoagulant, has been increasingly used in clinical practice, but the binding characteristics and influence of exogenous heparin on heparin-affinity proteins in the body are still unclear.
32458960	1	54	from	characteristics	217:231	arg1	proteins					288:295	heparin-affinity proteins	271:295	heparin-affinity proteins in the body	271:307	Heparin, as an effective anticoagulant, has been increasingly used in clinical practice, but the binding characteristics and influence of exogenous heparin on heparin-affinity proteins in the body are still unclear.
32458960	8	55	theme	affinity	1489:1496	arg1	proteins					1498:1505	affinity proteins	1489:1505	affinity proteins	1489:1505	This work provides a new insight into the binding between VEGF165 and heparin and offers a research framework to study the interaction between heparin and multiple heparin affinity proteins, which is helpful for guiding the safe application of heparin in the clinic.
32458960	8	56	theme	research	1408:1415	arg1	framework					1417:1425	a research framework	1406:1425	a research framework	1406:1425	This work provides a new insight into the binding between VEGF165 and heparin and offers a research framework to study the interaction between heparin and multiple heparin affinity proteins, which is helpful for guiding the safe application of heparin in the clinic.
32458960	8	56	theme	research	1408:1415	arg1	helpful					1517:1523	helpful	1517:1523	helpful	1517:1523	This work provides a new insight into the binding between VEGF165 and heparin and offers a research framework to study the interaction between heparin and multiple heparin affinity proteins, which is helpful for guiding the safe application of heparin in the clinic.
32458960	1	57	theme	effective	127:135	arg1	anticoagulant					137:149	an effective anticoagulant	124:149	an effective anticoagulant	124:149	Heparin, as an effective anticoagulant, has been increasingly used in clinical practice, but the binding characteristics and influence of exogenous heparin on heparin-affinity proteins in the body are still unclear.
32458960	8	58	theme	new	1338:1340	arg1	insight					1342:1348	a new insight	1336:1348	a new insight into the binding between VEGF165 and heparin	1336:1393	This work provides a new insight into the binding between VEGF165 and heparin and offers a research framework to study the interaction between heparin and multiple heparin affinity proteins, which is helpful for guiding the safe application of heparin in the clinic.
32458960	8	59	dep	framework	1417:1425	arg1	study					1430:1434	study	1430:1434	to study the interaction between heparin and multiple heparin affinity proteins	1427:1505	This work provides a new insight into the binding between VEGF165 and heparin and offers a research framework to study the interaction between heparin and multiple heparin affinity proteins, which is helpful for guiding the safe application of heparin in the clinic.
32458960	7	60	theme	hydrophobic	1230:1240	arg1	interaction					1242:1252	hydrophobic interaction	1230:1252	hydrophobic interaction	1230:1252	Results of MD simulation visually displayed the most likely binding conformation of VEGF165/heparin* complex, indicating that hydrogen bonding and hydrophobic interaction play a positive role in the binding between the two molecules.
32458960	3	61	theme	VEGF-A	656:661	arg1	form					648:651	the major form	638:651	the major form of VEGF-A	638:661	As an important step in the angiogenesis-related cascade, it is necessary to clarify the interaction between VEGF165 (the major form of VEGF-A) and heparin.
32458960	1	62	used	used	174:177	arg2	Heparin					112:118	Heparin	112:118	Heparin	112:118	Heparin, as an effective anticoagulant, has been increasingly used in clinical practice, but the binding characteristics and influence of exogenous heparin on heparin-affinity proteins in the body are still unclear.
32458960	6	63	theme	dissociation	1042:1053	arg1	process					1055:1061	the VEGF165/heparin complex dissociation process	1014:1061	the VEGF165/heparin complex dissociation process	1014:1061	Meanwhile, the kinetic and thermodynamic parameters of the VEGF165/heparin complex dissociation process were also obtained.
32458960	5	64	theme	binding	836:842	arg1	forces					844:849	binding forces	836:849	binding forces between VEGF165 and heparin at different loading rates	836:904	From the SMFS study, binding forces between VEGF165 and heparin at different loading rates were quantified under near-physiological conditions.
32458960	5	65	from	rates	900:904	arg1	heparin					871:877	heparin	871:877	heparin	871:877	From the SMFS study, binding forces between VEGF165 and heparin at different loading rates were quantified under near-physiological conditions.
32458960	5	65	from	rates	900:904	arg1	VEGF165					859:865	VEGF165	859:865	VEGF165	859:865	From the SMFS study, binding forces between VEGF165 and heparin at different loading rates were quantified under near-physiological conditions.
32458960	6	66	theme	thermodynamic	986:998	arg1	Meanwhile					959:967	Meanwhile	959:967	Meanwhile	959:967	Meanwhile, the kinetic and thermodynamic parameters of the VEGF165/heparin complex dissociation process were also obtained.
32458960	6	66	theme	thermodynamic	986:998	arg1	parameters					1000:1009	the kinetic and thermodynamic parameters	970:1009	the kinetic and thermodynamic parameters of the VEGF165/heparin complex dissociation process	970:1061	Meanwhile, the kinetic and thermodynamic parameters of the VEGF165/heparin complex dissociation process were also obtained.
32458960	2	67	theme	diseases	493:500	arg1	progression					450:460	progression	450:460	progression	450:460	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	2	67	theme	diseases	493:500	arg1	pathogenesis					433:444	pathogenesis	433:444	pathogenesis	433:444	Vascular endothelial growth factor A (VEGF-A) is a kind of protein with heparin affinity involved in the pathogenesis and progression of many angiogenesis-dependent diseases including cancer.
32458960	7	68	theme	VEGF165/heparin	1167:1181	arg1	complex					1184:1190	VEGF165/heparin* complex	1167:1190	VEGF165/heparin* complex	1167:1190	Results of MD simulation visually displayed the most likely binding conformation of VEGF165/heparin* complex, indicating that hydrogen bonding and hydrophobic interaction play a positive role in the binding between the two molecules.
32458960	8	69	from	application	1546:1556	arg1	clinic					1576:1581	the clinic	1572:1581	the clinic	1572:1581	This work provides a new insight into the binding between VEGF165 and heparin and offers a research framework to study the interaction between heparin and multiple heparin affinity proteins, which is helpful for guiding the safe application of heparin in the clinic.
32458960	7	70	theme	hydrogen	1209:1216	arg1	bonding					1218:1224	hydrogen bonding	1209:1224	hydrogen bonding	1209:1224	Results of MD simulation visually displayed the most likely binding conformation of VEGF165/heparin* complex, indicating that hydrogen bonding and hydrophobic interaction play a positive role in the binding between the two molecules.
33712153	2	0	theme	peel	446:449	arg1	wastes					451:456	fruit peel wastes	440:456	fruit peel wastes (aE-FPW)	440:465	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	2	0	theme	peel	446:449	arg1	aE-FPW					459:464	aE-FPW	459:464	aE-FPW	459:464	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	5	1	theme	BNC	1053:1055	arg1	11.44 g L-1					1064:1074	11.44 g L-1	1064:1074	11.44 g L-1	1064:1074	Statistical optimization of BNC based on Central Composite Design was performed to study the effect of significant parameters and the results demonstrated that the BNC yield (11.44 g L-1) was increased by 4.5 fold after optimization.
33712153	5	1	theme	BNC	1053:1055	arg1	yield					1057:1061	the BNC yield	1049:1061	the BNC yield (11.44 g L-1)	1049:1075	Statistical optimization of BNC based on Central Composite Design was performed to study the effect of significant parameters and the results demonstrated that the BNC yield (11.44 g L-1) was increased by 4.5 fold after optimization.
33712153	3	2	theme	rotten	626:631	arg1	apple					633:637	rotten apple	626:637	rotten apple	626:637	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
33712153	2	3	theme	carbon	485:490	arg1	source					492:497	a nutrient and carbon source	470:497	source	492:497	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	2	3	theme	carbon	485:490	arg1	prospect					383:390	the prospect	379:390	the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW)	379:465	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	3	4	theme	yielding	595:602	arg1	strain					604:609	a novel, high- yielding strain	580:609	a novel, high- yielding strain	580:609	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
33712153	4	5	theme	various	802:808	arg1	mediums					817:823	the various aE-FPW mediums	798:823	the various aE-FPW mediums	798:823	The physicochemical properties of BNC matrix collected from the various aE-FPW mediums were similar or advanced to those collected with the HS medium.
33712153	3	6	dep	novel	582:586	arg1	high-					589:593	high-	589:593	high-	589:593	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
33712153	0	7	theme	novel	96:100	arg1	DKH20					139:143	a novel strain Komagataeibacter xylinus IITR DKH20	94:143	a novel strain Komagataeibacter xylinus IITR DKH20	94:143	Valorization of fruit processing waste to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20.
33712153	3	8	theme	strain	604:609	arg1	use					573:575	the use	569:575	the use of a novel, high- yielding strain, isolated from rotten apple	569:637	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
33712153	4	9	theme	aE-FPW	810:815	arg1	mediums					817:823	the various aE-FPW mediums	798:823	the various aE-FPW mediums	798:823	The physicochemical properties of BNC matrix collected from the various aE-FPW mediums were similar or advanced to those collected with the HS medium.
33712153	2	10	theme	BNC	521:523	arg1	production					507:516	the production	503:516	the production of BNC	503:523	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	5	11	theme	Statistical	889:899	arg1	optimization					901:912	Statistical optimization	889:912	Statistical optimization of BNC based on Central Composite Design	889:953	Statistical optimization of BNC based on Central Composite Design was performed to study the effect of significant parameters and the results demonstrated that the BNC yield (11.44 g L-1) was increased by 4.5 fold after optimization.
33712153	0	12	theme	Komagataeibacter	109:124	arg1	DKH20					139:143	a novel strain Komagataeibacter xylinus IITR DKH20	94:143	a novel strain Komagataeibacter xylinus IITR DKH20	94:143	Valorization of fruit processing waste to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20.
33712153	4	13	theme	BNC	772:774	arg1	matrix					776:781	BNC matrix	772:781	BNC matrix collected from the various aE-FPW mediums	772:823	The physicochemical properties of BNC matrix collected from the various aE-FPW mediums were similar or advanced to those collected with the HS medium.
33712153	0	14	theme	strain	102:107	arg1	DKH20					139:143	a novel strain Komagataeibacter xylinus IITR DKH20	94:143	a novel strain Komagataeibacter xylinus IITR DKH20	94:143	Valorization of fruit processing waste to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20.
33712153	2	15	theme	fruit	440:444	arg1	wastes					451:456	fruit peel wastes	440:456	fruit peel wastes (aE-FPW)	440:465	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	2	15	theme	fruit	440:444	arg1	aE-FPW					459:464	aE-FPW	459:464	aE-FPW	459:464	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	5	16	theme	Central	930:936	arg1	Design					948:953	Central Composite Design	930:953	Central Composite Design	930:953	Statistical optimization of BNC based on Central Composite Design was performed to study the effect of significant parameters and the results demonstrated that the BNC yield (11.44 g L-1) was increased by 4.5 fold after optimization.
33712153	2	17	theme	extract	429:435	arg1	use					400:402	the use	396:402	the use of the different aqueous extract	396:435	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	1	18	theme	BNC	336:338	arg1	commercialization					340:356	BNC commercialization	336:356	BNC commercialization	336:356	To date, the production of bacterial nanocellulose (BNC) by standard methods has been well known, while the use of low-cost feedstock as an alternative medium still needs to be explored for BNC commercialization.
33712153	1	19	theme	bacterial	173:181	arg1	BNC					198:200	BNC	198:200	BNC	198:200	To date, the production of bacterial nanocellulose (BNC) by standard methods has been well known, while the use of low-cost feedstock as an alternative medium still needs to be explored for BNC commercialization.
33712153	1	19	theme	bacterial	173:181	arg1	nanocellulose					183:195	bacterial nanocellulose	173:195	bacterial nanocellulose (BNC)	173:201	To date, the production of bacterial nanocellulose (BNC) by standard methods has been well known, while the use of low-cost feedstock as an alternative medium still needs to be explored for BNC commercialization.
33712153	4	20	theme	matrix	776:781	arg1	similar					830:836	similar	830:836	similar	830:836	The physicochemical properties of BNC matrix collected from the various aE-FPW mediums were similar or advanced to those collected with the HS medium.
33712153	4	20	theme	matrix	776:781	arg1	properties					758:767	The physicochemical properties	738:767	The physicochemical properties of BNC matrix collected from the various aE-FPW mediums	738:823	The physicochemical properties of BNC matrix collected from the various aE-FPW mediums were similar or advanced to those collected with the HS medium.
33712153	1	21	theme	nanocellulose	183:195	arg1	production					159:168	the production	155:168	the production of bacterial nanocellulose (BNC) by standard methods	155:221	To date, the production of bacterial nanocellulose (BNC) by standard methods has been well known, while the use of low-cost feedstock as an alternative medium still needs to be explored for BNC commercialization.
33712153	0	22	theme	processing	22:31	arg1	waste					33:37	fruit processing waste	16:37	fruit processing waste	16:37	Valorization of fruit processing waste to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20.
33712153	3	23	theme	Komagataeibacter	665:680	arg1	IITR					690:693	Komagataeibacter xylinus IITR DKH20	665:699	Komagataeibacter xylinus IITR DKH20	665:699	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
33712153	3	23	theme	Komagataeibacter	665:680	arg1	objective					539:547	this objective	534:547	this objective	534:547	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
33712153	0	24	theme	IITR	134:137	arg1	DKH20					139:143	a novel strain Komagataeibacter xylinus IITR DKH20	94:143	a novel strain Komagataeibacter xylinus IITR DKH20	94:143	Valorization of fruit processing waste to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20.
33712153	0	25	theme	fruit	16:20	arg1	waste					33:37	fruit processing waste	16:37	fruit processing waste	16:37	Valorization of fruit processing waste to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20.
33712153	0	26	theme	xylinus	126:132	arg1	DKH20					139:143	a novel strain Komagataeibacter xylinus IITR DKH20	94:143	a novel strain Komagataeibacter xylinus IITR DKH20	94:143	Valorization of fruit processing waste to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20.
33712153	2	27	theme	aqueous	421:427	arg1	extract					429:435	the different aqueous extract	407:435	the different aqueous extract	407:435	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	1	28	theme	low-cost	261:268	arg1	feedstock					270:278	low-cost feedstock	261:278	low-cost feedstock	261:278	To date, the production of bacterial nanocellulose (BNC) by standard methods has been well known, while the use of low-cost feedstock as an alternative medium still needs to be explored for BNC commercialization.
33712153	5	29	theme	significant	992:1002	arg1	parameters					1004:1013	significant parameters	992:1013	significant parameters	992:1013	Statistical optimization of BNC based on Central Composite Design was performed to study the effect of significant parameters and the results demonstrated that the BNC yield (11.44 g L-1) was increased by 4.5 fold after optimization.
33712153	5	30	theme	Composite	938:946	arg1	Design					948:953	Central Composite Design	930:953	Central Composite Design	930:953	Statistical optimization of BNC based on Central Composite Design was performed to study the effect of significant parameters and the results demonstrated that the BNC yield (11.44 g L-1) was increased by 4.5 fold after optimization.
33712153	0	31	theme	waste	33:37	arg1	Valorization					0:11	Valorization	0:11	Valorization of fruit processing waste to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20.	0:144	Valorization of fruit processing waste to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20.
33712153	1	32	theme	feedstock	270:278	arg1	use					254:256	the use	250:256	the use of low-cost feedstock as an alternative medium	250:303	To date, the production of bacterial nanocellulose (BNC) by standard methods has been well known, while the use of low-cost feedstock as an alternative medium still needs to be explored for BNC commercialization.
33712153	2	33	theme	nutrient	472:479	arg1	source					492:497	a nutrient and carbon source	470:497	source	492:497	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	2	33	theme	nutrient	472:479	arg1	prospect					383:390	the prospect	379:390	the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW)	379:465	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	5	34	theme	parameters	1004:1013	arg1	effect					982:987	the effect	978:987	the effect of significant parameters	978:1013	Statistical optimization of BNC based on Central Composite Design was performed to study the effect of significant parameters and the results demonstrated that the BNC yield (11.44 g L-1) was increased by 4.5 fold after optimization.
33712153	4	35	theme	HS	878:879	arg1	medium					881:886	the HS medium	874:886	the HS medium	874:886	The physicochemical properties of BNC matrix collected from the various aE-FPW mediums were similar or advanced to those collected with the HS medium.
33712153	0	36	theme	high	50:53	arg1	nanocellulose					77:89	high value-added bacterial nanocellulose	50:89	high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20	50:143	Valorization of fruit processing waste to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20.
33712153	3	37	attach	isolated	612:619	arg1	apple					633:637	rotten apple	626:637	rotten apple	626:637	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
33712153	3	37	attach	isolated	612:619	arg2	strain					604:609	a novel, high- yielding strain	580:609	a novel, high- yielding strain	580:609	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
33712153	2	38	theme	wastes	451:456	arg1	source					492:497	a nutrient and carbon source	470:497	source	492:497	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	2	38	theme	wastes	451:456	arg1	prospect					383:390	the prospect	379:390	the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW)	379:465	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	2	39	theme	different	411:419	arg1	extract					429:435	the different aqueous extract	407:435	the different aqueous extract	407:435	This study explores the prospect for the use of the different aqueous extract of fruit peel wastes (aE-FPW) as a nutrient and carbon source for the production of BNC.
33712153	3	40	theme	xylinus	682:688	arg1	IITR					690:693	Komagataeibacter xylinus IITR DKH20	665:699	Komagataeibacter xylinus IITR DKH20	665:699	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
33712153	3	40	theme	xylinus	682:688	arg1	objective					539:547	this objective	534:547	this objective	534:547	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
33712153	4	41	theme	physicochemical	742:756	arg1	similar					830:836	similar	830:836	similar	830:836	The physicochemical properties of BNC matrix collected from the various aE-FPW mediums were similar or advanced to those collected with the HS medium.
33712153	4	41	theme	physicochemical	742:756	arg1	properties					758:767	The physicochemical properties	738:767	The physicochemical properties of BNC matrix collected from the various aE-FPW mediums	738:823	The physicochemical properties of BNC matrix collected from the various aE-FPW mediums were similar or advanced to those collected with the HS medium.
33712153	1	42	theme	alternative	286:296	arg1	medium					298:303	an alternative medium	283:303	an alternative medium	283:303	To date, the production of bacterial nanocellulose (BNC) by standard methods has been well known, while the use of low-cost feedstock as an alternative medium still needs to be explored for BNC commercialization.
33712153	5	43	theme	BNC	917:919	arg1	optimization					901:912	Statistical optimization	889:912	Statistical optimization of BNC based on Central Composite Design	889:953	Statistical optimization of BNC based on Central Composite Design was performed to study the effect of significant parameters and the results demonstrated that the BNC yield (11.44 g L-1) was increased by 4.5 fold after optimization.
33712153	1	44	theme	standard	206:213	arg1	methods					215:221	standard methods	206:221	standard methods	206:221	To date, the production of bacterial nanocellulose (BNC) by standard methods has been well known, while the use of low-cost feedstock as an alternative medium still needs to be explored for BNC commercialization.
33712153	0	45	theme	bacterial	67:75	arg1	nanocellulose					77:89	high value-added bacterial nanocellulose	50:89	high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20	50:143	Valorization of fruit processing waste to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20.
33712153	3	46	theme	novel	582:586	arg1	strain					604:609	a novel, high- yielding strain	580:609	a novel, high- yielding strain	580:609	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
33712153	3	47	theme	16 s	707:710	arg1	analysis					728:735	16 s rRNA sequencing analysis	707:735	16 s rRNA sequencing analysis	707:735	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
33712153	0	48	theme	value-added	55:65	arg1	nanocellulose					77:89	high value-added bacterial nanocellulose	50:89	high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20	50:143	Valorization of fruit processing waste to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20.
33712153	0	49	dep	Valorization	0:11	arg1	produce					42:48	produce	42:48	to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20	39:143	Valorization of fruit processing waste to produce high value-added bacterial nanocellulose by a novel strain Komagataeibacter xylinus IITR DKH20.
33712153	3	50	theme	sequencing	717:726	arg1	analysis					728:735	16 s rRNA sequencing analysis	707:735	16 s rRNA sequencing analysis	707:735	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
33712153	3	51	theme	rRNA	712:715	arg1	analysis					728:735	16 s rRNA sequencing analysis	707:735	16 s rRNA sequencing analysis	707:735	Herein, this objective was accomplished by the use of a novel, high- yielding strain, isolated from rotten apple and further identified as Komagataeibacter xylinus IITR DKH20 using 16 s rRNA sequencing analysis.
32653598	0	0	theme	colyophilized	87:99	arg1	systems					101:107	colyophilized systems	87:107	colyophilized systems	87:107	Anomalous behavior of mannitol hemihydrate: Implications on sucrose crystallization in colyophilized systems.
32653598	3	1	theme	sucrose	657:663	arg1	stability					644:652	the physical stability	631:652	the physical stability of sucrose	631:663	Our aim was to determine the influence of water vapor pressure on the kinetics of MHH dehydration and the implications on the physical stability of sucrose.
32653598	1	2	theme	two	364:366	arg1	mixture					349:355	a mixture	347:355	a mixture of the two	347:366	When solutions containing mannitol and sucrose are freeze-dried, depending on the processing conditions and the formulation composition, mannitol can crystallize in the anhydrous form, as mannitol hemihydrate (MHH; C6H14O6·0.5H2O) or as a mixture of the two.
32653598	8	3	theme	rubber	1419:1424	arg1	stoppers					1426:1433	the rubber stoppers	1415:1433	the rubber stoppers	1415:1433	There was also evidence of moisture transfer from the lyophile to the rubber stoppers.
32653598	3	4	theme	physical	635:642	arg1	stability					644:652	the physical stability	631:652	the physical stability of sucrose	631:663	Our aim was to determine the influence of water vapor pressure on the kinetics of MHH dehydration and the implications on the physical stability of sucrose.
32653598	4	5	theme	crystallization	791:805	arg1	kinetics					751:758	the kinetics	747:758	the kinetics of MHH dehydration and sucrose crystallization	747:805	Therefore, the lyophiles were exposed to a range of relative humidities (RH) and the kinetics of MHH dehydration and sucrose crystallization were monitored by X-ray diffractometry.
32653598	8	6	theme	transfer	1385:1392	arg1	evidence					1364:1371	evidence	1364:1371	evidence of moisture transfer from the lyophile to the rubber stoppers	1364:1433	There was also evidence of moisture transfer from the lyophile to the rubber stoppers.
32653598	5	7	theme	water	995:999	arg1	content					1001:1007	water content	995:1007	water content	995:1007	A second set of vials (rubber stoppers fitted with humidity/temperature sensor) were stored at 40 °C, the headspace RH was continually recorded and water content was determined by Karl Fischer titrimetry.
32653598	2	8	theme	drug	495:498	arg1	product					500:506	the final drug product	485:506	the final drug product	485:506	The retention of MHH in the final lyophile, and its dehydration during product storage could lead to instability of the final drug product.
32653598	1	9	contain	containing	125:134	arg2	sucrose					149:155	sucrose	149:155	sucrose	149:155	When solutions containing mannitol and sucrose are freeze-dried, depending on the processing conditions and the formulation composition, mannitol can crystallize in the anhydrous form, as mannitol hemihydrate (MHH; C6H14O6·0.5H2O) or as a mixture of the two.
32653598	1	9	contain	containing	125:134	arg2	mannitol					136:143	mannitol	136:143	mannitol	136:143	When solutions containing mannitol and sucrose are freeze-dried, depending on the processing conditions and the formulation composition, mannitol can crystallize in the anhydrous form, as mannitol hemihydrate (MHH; C6H14O6·0.5H2O) or as a mixture of the two.
32653598	1	9	contain	containing	125:134	arg1	solutions					115:123	solutions	115:123	solutions containing mannitol and sucrose	115:155	When solutions containing mannitol and sucrose are freeze-dried, depending on the processing conditions and the formulation composition, mannitol can crystallize in the anhydrous form, as mannitol hemihydrate (MHH; C6H14O6·0.5H2O) or as a mixture of the two.
32653598	7	10	theme	MHH	1286:1288	arg1	dehydration					1290:1300	MHH dehydration	1286:1300	MHH dehydration	1286:1300	An increase in headspace RH and decrease in lyophile water content in sealed vials attributed to MHH dehydration, eventually triggered sucrose crystallization.
32653598	6	11	theme	Smith-Topley	1168:1179	arg1	effect					1181:1186	the Smith-Topley effect	1164:1186	the Smith-Topley effect	1164:1186	The dehydration rate of MHH increased as a function of water vapor pressure, an anomalous behavior explained by the Smith-Topley effect.
32653598	6	12	theme	water	1107:1111	arg1	pressure					1119:1126	water vapor pressure	1107:1126	water vapor pressure	1107:1126	The dehydration rate of MHH increased as a function of water vapor pressure, an anomalous behavior explained by the Smith-Topley effect.
32653598	3	13	from	implications	615:626	arg1	stability					644:652	the physical stability	631:652	the physical stability of sucrose	631:663	Our aim was to determine the influence of water vapor pressure on the kinetics of MHH dehydration and the implications on the physical stability of sucrose.
32653598	1	14	theme	anhydrous	279:287	arg1	form					289:292	the anhydrous form	275:292	the anhydrous form	275:292	When solutions containing mannitol and sucrose are freeze-dried, depending on the processing conditions and the formulation composition, mannitol can crystallize in the anhydrous form, as mannitol hemihydrate (MHH; C6H14O6·0.5H2O) or as a mixture of the two.
32653598	2	15	theme	final	489:493	arg1	product					500:506	the final drug product	485:506	the final drug product	485:506	The retention of MHH in the final lyophile, and its dehydration during product storage could lead to instability of the final drug product.
32653598	5	16	dep	vials	863:867	arg1	stoppers					877:884	rubber stoppers	870:884	rubber stoppers fitted with humidity/temperature sensor	870:924	A second set of vials (rubber stoppers fitted with humidity/temperature sensor) were stored at 40 °C, the headspace RH was continually recorded and water content was determined by Karl Fischer titrimetry.
32653598	5	17	theme	humidity/temperature	898:917	arg1	sensor					919:924	humidity/temperature sensor	898:924	humidity/temperature sensor	898:924	A second set of vials (rubber stoppers fitted with humidity/temperature sensor) were stored at 40 °C, the headspace RH was continually recorded and water content was determined by Karl Fischer titrimetry.
32653598	3	18	from	kinetics	579:586	arg1	stability					644:652	the physical stability	631:652	the physical stability of sucrose	631:663	Our aim was to determine the influence of water vapor pressure on the kinetics of MHH dehydration and the implications on the physical stability of sucrose.
32653598	8	19	from	lyophile	1403:1410	arg1	transfer					1385:1392	moisture transfer	1376:1392	moisture transfer from the lyophile to the rubber stoppers	1376:1433	There was also evidence of moisture transfer from the lyophile to the rubber stoppers.
32653598	8	19	from	lyophile	1403:1410	arg1	evidence					1364:1371	evidence	1364:1371	evidence of moisture transfer from the lyophile to the rubber stoppers	1364:1433	There was also evidence of moisture transfer from the lyophile to the rubber stoppers.
32653598	2	20	from	dehydration	421:431	arg1	lyophile					403:410	the final lyophile	393:410	the final lyophile	393:410	The retention of MHH in the final lyophile, and its dehydration during product storage could lead to instability of the final drug product.
32653598	4	21	theme	dehydration	767:777	arg1	kinetics					751:758	the kinetics	747:758	the kinetics of MHH dehydration and sucrose crystallization	747:805	Therefore, the lyophiles were exposed to a range of relative humidities (RH) and the kinetics of MHH dehydration and sucrose crystallization were monitored by X-ray diffractometry.
32653598	4	22	theme	relative	718:725	arg1	RH					739:740	RH	739:740	RH	739:740	Therefore, the lyophiles were exposed to a range of relative humidities (RH) and the kinetics of MHH dehydration and sucrose crystallization were monitored by X-ray diffractometry.
32653598	4	22	theme	relative	718:725	arg1	humidities					727:736	relative humidities	718:736	relative humidities (RH)	718:741	Therefore, the lyophiles were exposed to a range of relative humidities (RH) and the kinetics of MHH dehydration and sucrose crystallization were monitored by X-ray diffractometry.
32653598	7	23	theme	lyophile	1233:1240	arg1	content					1248:1254	lyophile water content	1233:1254	lyophile water content in sealed vials attributed to MHH dehydration	1233:1300	An increase in headspace RH and decrease in lyophile water content in sealed vials attributed to MHH dehydration, eventually triggered sucrose crystallization.
32653598	5	24	theme	Fischer	1032:1038	arg1	titrimetry					1040:1049	Karl Fischer titrimetry	1027:1049	Karl Fischer titrimetry	1027:1049	A second set of vials (rubber stoppers fitted with humidity/temperature sensor) were stored at 40 °C, the headspace RH was continually recorded and water content was determined by Karl Fischer titrimetry.
32653598	4	25	theme	MHH	763:765	arg1	dehydration					767:777	MHH dehydration	763:777	MHH dehydration	763:777	Therefore, the lyophiles were exposed to a range of relative humidities (RH) and the kinetics of MHH dehydration and sucrose crystallization were monitored by X-ray diffractometry.
32653598	5	26	theme	Karl	1027:1030	arg1	titrimetry					1040:1049	Karl Fischer titrimetry	1027:1049	Karl Fischer titrimetry	1027:1049	A second set of vials (rubber stoppers fitted with humidity/temperature sensor) were stored at 40 °C, the headspace RH was continually recorded and water content was determined by Karl Fischer titrimetry.
32653598	1	27	dep	MHH	320:322	arg1	C6H14O6·0.5H2O					325:338	C6H14O6·0.5H2O	325:338	MHH; C6H14O6·0.5H2O	320:338	When solutions containing mannitol and sucrose are freeze-dried, depending on the processing conditions and the formulation composition, mannitol can crystallize in the anhydrous form, as mannitol hemihydrate (MHH; C6H14O6·0.5H2O) or as a mixture of the two.
32653598	4	28	theme	sucrose	783:789	arg1	crystallization					791:805	sucrose crystallization	783:805	sucrose crystallization	783:805	Therefore, the lyophiles were exposed to a range of relative humidities (RH) and the kinetics of MHH dehydration and sucrose crystallization were monitored by X-ray diffractometry.
32653598	7	29	from	increase	1192:1199	arg1	RH					1214:1215	headspace RH	1204:1215	headspace RH	1204:1215	An increase in headspace RH and decrease in lyophile water content in sealed vials attributed to MHH dehydration, eventually triggered sucrose crystallization.
32653598	7	29	from	increase	1192:1199	arg1	content					1248:1254	lyophile water content	1233:1254	lyophile water content in sealed vials attributed to MHH dehydration	1233:1300	An increase in headspace RH and decrease in lyophile water content in sealed vials attributed to MHH dehydration, eventually triggered sucrose crystallization.
32653598	0	30	from	Implications	44:55	arg1	crystallization					68:82	sucrose crystallization	60:82	sucrose crystallization in colyophilized systems	60:107	Anomalous behavior of mannitol hemihydrate: Implications on sucrose crystallization in colyophilized systems.
32653598	1	31	theme	processing	192:201	arg1	conditions					203:212	the processing conditions	188:212	the processing conditions	188:212	When solutions containing mannitol and sucrose are freeze-dried, depending on the processing conditions and the formulation composition, mannitol can crystallize in the anhydrous form, as mannitol hemihydrate (MHH; C6H14O6·0.5H2O) or as a mixture of the two.
32653598	0	32	theme	Anomalous	0:8	arg1	behavior					10:17	Anomalous behavior	0:17	Anomalous behavior of mannitol	0:29	Anomalous behavior of mannitol hemihydrate: Implications on sucrose crystallization in colyophilized systems.
32653598	5	33	theme	rubber	870:875	arg1	stoppers					877:884	rubber stoppers	870:884	rubber stoppers fitted with humidity/temperature sensor	870:924	A second set of vials (rubber stoppers fitted with humidity/temperature sensor) were stored at 40 °C, the headspace RH was continually recorded and water content was determined by Karl Fischer titrimetry.
32653598	3	34	from	influence	538:546	arg1	implications					615:626	the implications	611:626	the implications on the physical stability of sucrose	611:663	Our aim was to determine the influence of water vapor pressure on the kinetics of MHH dehydration and the implications on the physical stability of sucrose.
32653598	3	34	from	influence	538:546	arg1	kinetics					579:586	the kinetics	575:586	the kinetics of MHH dehydration	575:605	Our aim was to determine the influence of water vapor pressure on the kinetics of MHH dehydration and the implications on the physical stability of sucrose.
32653598	7	35	theme	water	1242:1246	arg1	content					1248:1254	lyophile water content	1233:1254	lyophile water content in sealed vials attributed to MHH dehydration	1233:1300	An increase in headspace RH and decrease in lyophile water content in sealed vials attributed to MHH dehydration, eventually triggered sucrose crystallization.
32653598	0	36	theme	mannitol	22:29	arg1	behavior					10:17	Anomalous behavior	0:17	Anomalous behavior of mannitol	0:29	Anomalous behavior of mannitol hemihydrate: Implications on sucrose crystallization in colyophilized systems.
32653598	6	37	theme	pressure	1119:1126	arg1	function					1095:1102	a function	1093:1102	a function of water vapor pressure	1093:1126	The dehydration rate of MHH increased as a function of water vapor pressure, an anomalous behavior explained by the Smith-Topley effect.
32653598	6	37	theme	pressure	1119:1126	arg1	behavior					1142:1149	an anomalous behavior	1129:1149	an anomalous behavior explained by the Smith-Topley effect	1129:1186	The dehydration rate of MHH increased as a function of water vapor pressure, an anomalous behavior explained by the Smith-Topley effect.
32653598	6	38	theme	MHH	1076:1078	arg1	rate					1068:1071	The dehydration rate	1052:1071	The dehydration rate of MHH	1052:1078	The dehydration rate of MHH increased as a function of water vapor pressure, an anomalous behavior explained by the Smith-Topley effect.
32653598	2	39	theme	final	397:401	arg1	lyophile					403:410	the final lyophile	393:410	the final lyophile	393:410	The retention of MHH in the final lyophile, and its dehydration during product storage could lead to instability of the final drug product.
32653598	1	40	theme	mannitol	298:305	arg1	MHH					320:322	MHH	320:322	MHH; C6H14O6·0.5H2O	320:338	When solutions containing mannitol and sucrose are freeze-dried, depending on the processing conditions and the formulation composition, mannitol can crystallize in the anhydrous form, as mannitol hemihydrate (MHH; C6H14O6·0.5H2O) or as a mixture of the two.
32653598	1	40	theme	mannitol	298:305	arg1	hemihydrate					307:317	mannitol hemihydrate	298:317	mannitol hemihydrate (MHH; C6H14O6·0.5H2O)	298:339	When solutions containing mannitol and sucrose are freeze-dried, depending on the processing conditions and the formulation composition, mannitol can crystallize in the anhydrous form, as mannitol hemihydrate (MHH; C6H14O6·0.5H2O) or as a mixture of the two.
32653598	3	41	theme	dehydration	595:605	arg1	implications					615:626	the implications	611:626	the implications on the physical stability of sucrose	611:663	Our aim was to determine the influence of water vapor pressure on the kinetics of MHH dehydration and the implications on the physical stability of sucrose.
32653598	3	41	theme	dehydration	595:605	arg1	kinetics					579:586	the kinetics	575:586	the kinetics of MHH dehydration	575:605	Our aim was to determine the influence of water vapor pressure on the kinetics of MHH dehydration and the implications on the physical stability of sucrose.
32653598	7	42	theme	sucrose	1324:1330	arg1	crystallization					1332:1346	sucrose crystallization	1324:1346	sucrose crystallization	1324:1346	An increase in headspace RH and decrease in lyophile water content in sealed vials attributed to MHH dehydration, eventually triggered sucrose crystallization.
32653598	8	43	from	evidence	1364:1371	arg1	lyophile					1403:1410	the lyophile	1399:1410	the lyophile	1399:1410	There was also evidence of moisture transfer from the lyophile to the rubber stoppers.
32653598	7	44	theme	headspace	1204:1212	arg1	RH					1214:1215	headspace RH	1204:1215	headspace RH	1204:1215	An increase in headspace RH and decrease in lyophile water content in sealed vials attributed to MHH dehydration, eventually triggered sucrose crystallization.
32653598	3	45	theme	water	551:555	arg1	pressure					563:570	water vapor pressure	551:570	water vapor pressure	551:570	Our aim was to determine the influence of water vapor pressure on the kinetics of MHH dehydration and the implications on the physical stability of sucrose.
32653598	1	46	theme	formulation	222:232	arg1	composition					234:244	the formulation composition	218:244	the formulation composition	218:244	When solutions containing mannitol and sucrose are freeze-dried, depending on the processing conditions and the formulation composition, mannitol can crystallize in the anhydrous form, as mannitol hemihydrate (MHH; C6H14O6·0.5H2O) or as a mixture of the two.
32653598	2	47	theme	product	440:446	arg1	storage					448:454	product storage	440:454	product storage	440:454	The retention of MHH in the final lyophile, and its dehydration during product storage could lead to instability of the final drug product.
32653598	2	48	theme	product	500:506	arg1	instability					470:480	instability	470:480	instability of the final drug product	470:506	The retention of MHH in the final lyophile, and its dehydration during product storage could lead to instability of the final drug product.
32653598	0	49	from	crystallization	68:82	arg1	systems					101:107	colyophilized systems	87:107	colyophilized systems	87:107	Anomalous behavior of mannitol hemihydrate: Implications on sucrose crystallization in colyophilized systems.
32653598	3	50	theme	vapor	557:561	arg1	pressure					563:570	water vapor pressure	551:570	water vapor pressure	551:570	Our aim was to determine the influence of water vapor pressure on the kinetics of MHH dehydration and the implications on the physical stability of sucrose.
32653598	2	51	theme	MHH	386:388	arg1	retention					373:381	The retention	369:381	The retention of MHH in the final lyophile	369:410	The retention of MHH in the final lyophile, and its dehydration during product storage could lead to instability of the final drug product.
32653598	2	51	theme	MHH	386:388	arg1	dehydration					421:431	its dehydration	417:431	its dehydration during product storage	417:454	The retention of MHH in the final lyophile, and its dehydration during product storage could lead to instability of the final drug product.
32653598	7	52	theme	sealed	1259:1264	arg1	vials					1266:1270	sealed vials	1259:1270	sealed vials attributed to MHH dehydration	1259:1300	An increase in headspace RH and decrease in lyophile water content in sealed vials attributed to MHH dehydration, eventually triggered sucrose crystallization.
32653598	3	53	theme	MHH	591:593	arg1	dehydration					595:605	MHH dehydration	591:605	MHH dehydration	591:605	Our aim was to determine the influence of water vapor pressure on the kinetics of MHH dehydration and the implications on the physical stability of sucrose.
32653598	5	54	theme	headspace	953:961	arg1	RH					963:964	the headspace RH	949:964	the headspace RH	949:964	A second set of vials (rubber stoppers fitted with humidity/temperature sensor) were stored at 40 °C, the headspace RH was continually recorded and water content was determined by Karl Fischer titrimetry.
32653598	5	55	theme	second	849:854	arg1	set					856:858	A second set	847:858	A second set of vials (rubber stoppers fitted with humidity/temperature sensor)	847:925	A second set of vials (rubber stoppers fitted with humidity/temperature sensor) were stored at 40 °C, the headspace RH was continually recorded and water content was determined by Karl Fischer titrimetry.
32653598	5	55	theme	second	849:854	arg1	vials					863:867	vials	863:867	vials (rubber stoppers fitted with humidity/temperature sensor)	863:925	A second set of vials (rubber stoppers fitted with humidity/temperature sensor) were stored at 40 °C, the headspace RH was continually recorded and water content was determined by Karl Fischer titrimetry.
32653598	4	56	theme	X-ray	825:829	arg1	diffractometry					831:844	X-ray diffractometry	825:844	X-ray diffractometry	825:844	Therefore, the lyophiles were exposed to a range of relative humidities (RH) and the kinetics of MHH dehydration and sucrose crystallization were monitored by X-ray diffractometry.
32653598	6	57	theme	anomalous	1132:1140	arg1	behavior					1142:1149	an anomalous behavior	1129:1149	an anomalous behavior explained by the Smith-Topley effect	1129:1186	The dehydration rate of MHH increased as a function of water vapor pressure, an anomalous behavior explained by the Smith-Topley effect.
32653598	6	57	theme	anomalous	1132:1140	arg1	function					1095:1102	a function	1093:1102	a function of water vapor pressure	1093:1126	The dehydration rate of MHH increased as a function of water vapor pressure, an anomalous behavior explained by the Smith-Topley effect.
32653598	7	58	from	decrease	1221:1228	arg1	RH					1214:1215	headspace RH	1204:1215	headspace RH	1204:1215	An increase in headspace RH and decrease in lyophile water content in sealed vials attributed to MHH dehydration, eventually triggered sucrose crystallization.
32653598	7	58	from	decrease	1221:1228	arg1	content					1248:1254	lyophile water content	1233:1254	lyophile water content in sealed vials attributed to MHH dehydration	1233:1300	An increase in headspace RH and decrease in lyophile water content in sealed vials attributed to MHH dehydration, eventually triggered sucrose crystallization.
32653598	6	59	theme	dehydration	1056:1066	arg1	rate					1068:1071	The dehydration rate	1052:1071	The dehydration rate of MHH	1052:1078	The dehydration rate of MHH increased as a function of water vapor pressure, an anomalous behavior explained by the Smith-Topley effect.
32653598	2	60	from	retention	373:381	arg1	lyophile					403:410	the final lyophile	393:410	the final lyophile	393:410	The retention of MHH in the final lyophile, and its dehydration during product storage could lead to instability of the final drug product.
32653598	8	61	theme	moisture	1376:1383	arg1	transfer					1385:1392	moisture transfer	1376:1392	moisture transfer from the lyophile to the rubber stoppers	1376:1433	There was also evidence of moisture transfer from the lyophile to the rubber stoppers.
32653598	4	62	theme	humidities	727:736	arg1	range					709:713	a range	707:713	a range of relative humidities (RH)	707:741	Therefore, the lyophiles were exposed to a range of relative humidities (RH) and the kinetics of MHH dehydration and sucrose crystallization were monitored by X-ray diffractometry.
32653598	5	63	theme	vials	863:867	arg1	set					856:858	A second set	847:858	A second set of vials (rubber stoppers fitted with humidity/temperature sensor)	847:925	A second set of vials (rubber stoppers fitted with humidity/temperature sensor) were stored at 40 °C, the headspace RH was continually recorded and water content was determined by Karl Fischer titrimetry.
32653598	5	63	theme	vials	863:867	arg1	vials					863:867	vials	863:867	vials (rubber stoppers fitted with humidity/temperature sensor)	863:925	A second set of vials (rubber stoppers fitted with humidity/temperature sensor) were stored at 40 °C, the headspace RH was continually recorded and water content was determined by Karl Fischer titrimetry.
32653598	3	64	theme	pressure	563:570	arg1	influence					538:546	the influence	534:546	the influence of water vapor pressure on the kinetics of MHH dehydration and the implications on the physical stability of sucrose	534:663	Our aim was to determine the influence of water vapor pressure on the kinetics of MHH dehydration and the implications on the physical stability of sucrose.
32653598	0	65	theme	sucrose	60:66	arg1	crystallization					68:82	sucrose crystallization	60:82	sucrose crystallization in colyophilized systems	60:107	Anomalous behavior of mannitol hemihydrate: Implications on sucrose crystallization in colyophilized systems.
32653598	6	66	theme	vapor	1113:1117	arg1	pressure					1119:1126	water vapor pressure	1107:1126	water vapor pressure	1107:1126	The dehydration rate of MHH increased as a function of water vapor pressure, an anomalous behavior explained by the Smith-Topley effect.
32653598	7	67	from	content	1248:1254	arg1	vials					1266:1270	sealed vials	1259:1270	sealed vials attributed to MHH dehydration	1259:1300	An increase in headspace RH and decrease in lyophile water content in sealed vials attributed to MHH dehydration, eventually triggered sucrose crystallization.
32793515	4	0	from	alterations	541:551	arg1	patients					582:589	CHD patients	578:589	CHD patients	578:589	We analyzed the alterations of the gut microbiome in CHD patients and investigated the relationship between these alterations and the pathological indicators.
32793515	5	1	located	observed	857:864	arg2	decrease					815:822	a decrease	813:822	a decrease in high-density lipoprotein	813:850	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	5	1	located	observed	857:864	arg2	increase					754:761	a significant increase	740:761	a significant increase in lipopolysaccharides and white blood cells	740:806	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	5	1	located	observed	857:864	arg1	blood					873:877	the blood	869:877	the blood of CHD patients	869:893	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	3	2	with	patients	450:457	arg1	disease					509:515	non-stenosis coronary heart disease	481:515	non-stenosis coronary heart disease (NCHD)	481:522	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	3	2	with	patients	450:457	arg1	NCHD					518:521	NCHD	518:521	NCHD	518:521	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	6	3	contain	had	967:969	arg2	index					1002:1006	a significantly higher Shannon index	971:1006	a significantly higher Shannon index than that of the HT group	971:1032	The gut microbiota of the NCHD group had a significantly higher Shannon index than that of the HT group.
32793515	6	3	contain	had	967:969	arg1	microbiota					938:947	The gut microbiota	930:947	The gut microbiota of the NCHD group	930:965	The gut microbiota of the NCHD group had a significantly higher Shannon index than that of the HT group.
32793515	1	4	theme	gut	130:132	arg1	microbiota					134:143	gut microbiota	130:143	gut microbiota	130:143	Coronary heart disease (CHD) is closely related to gut microbiota, which may be significantly affected by ethnicity and the environment.
32793515	9	5	theme	arachidonic	1657:1667	arg1	metabolism					1674:1683	arachidonic acid metabolism	1657:1683	arachidonic acid metabolism	1657:1683	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	9	6	theme	amino	1501:1505	arg1	metabolism					1512:1521	amino acid metabolism	1501:1521	amino acid metabolism	1501:1521	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	7	7	theme	groups	1118:1123	arg1	functions					1095:1103	functions	1095:1103	functions	1095:1103	Adonis analysis showed that both microbial compositions and functions of the three groups were significantly separated.
32793515	7	7	theme	groups	1118:1123	arg1	compositions					1078:1089	microbial compositions	1068:1089	microbial compositions	1068:1089	Adonis analysis showed that both microbial compositions and functions of the three groups were significantly separated.
32793515	9	8	theme	lipid	1593:1597	arg1	degradation					1641:1651	fatty acid degradation	1630:1651	fatty acid degradation	1630:1651	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	9	8	theme	lipid	1593:1597	arg1	pathways					1610:1617	two lipid metabolism pathways	1589:1617	two lipid metabolism pathways	1589:1617	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	9	8	theme	lipid	1593:1597	arg1	metabolism					1674:1683	arachidonic acid metabolism	1657:1683	arachidonic acid metabolism	1657:1683	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	0	9	from	Alterations	0:10	arg1	Patients					41:48	Tibetan Patients	33:48	Tibetan Patients With Coronary Heart Disease	33:76	Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease.
32793515	2	10	theme	CHD	266:268	arg1	patients					270:277	Tibetan CHD patients	258:277	Tibetan CHD patients living in the Qinghai-Tibet Plateau	258:313	Knowledge regarding the gut microbiome of Tibetan CHD patients living in the Qinghai-Tibet Plateau is very limited.
32793515	5	11	theme	HT	920:921	arg1	group					923:927	the HT group	916:927	the HT group	916:927	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	9	12	theme	metabolism	1512:1521	arg1	pathways					1489:1496	four pathways	1484:1496	four pathways	1484:1496	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	9	12	theme	metabolism	1512:1521	arg1	biosynthesis					1541:1552	arginine biosynthesis	1532:1552	arginine biosynthesis	1532:1552	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	9	12	theme	metabolism	1512:1521	arg1	metabolism					1568:1577	histidine metabolism	1558:1577	histidine metabolism	1558:1577	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	2	13	theme	Tibetan	258:264	arg1	patients					270:277	Tibetan CHD patients	258:277	Tibetan CHD patients living in the Qinghai-Tibet Plateau	258:313	Knowledge regarding the gut microbiome of Tibetan CHD patients living in the Qinghai-Tibet Plateau is very limited.
32793515	3	14	theme	coronary	494:501	arg1	disease					509:515	non-stenosis coronary heart disease	481:515	non-stenosis coronary heart disease (NCHD)	481:522	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	3	14	theme	coronary	494:501	arg1	NCHD					518:521	NCHD	518:521	NCHD	518:521	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	9	15	theme	CHD	1703:1705	arg1	group					1707:1711	the CHD group	1699:1711	the CHD group	1699:1711	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	4	16	theme	pathological	659:670	arg1	indicators					672:681	the pathological indicators	655:681	the pathological indicators	655:681	We analyzed the alterations of the gut microbiome in CHD patients and investigated the relationship between these alterations and the pathological indicators.
32793515	5	17	theme	blood	796:800	arg1	cells					802:806	white blood cells	790:806	white blood cells	790:806	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	11	18	theme	Tibetan	1950:1956	arg1	patients					1958:1965	Tibetan patients	1950:1965	Tibetan patients	1950:1965	Our study will provide insights into the understanding of CHD, leading to better diagnosis and treatment of Tibetan patients.
32793515	5	19	theme	CHD	882:884	arg1	patients					886:893	CHD patients	882:893	CHD patients	882:893	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	5	20	theme	white	790:794	arg1	cells					802:806	white blood cells	790:806	white blood cells	790:806	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	6	21	theme	Shannon	994:1000	arg1	index					1002:1006	a significantly higher Shannon index	971:1006	a significantly higher Shannon index than that of the HT group	971:1032	The gut microbiota of the NCHD group had a significantly higher Shannon index than that of the HT group.
32793515	3	22	with	patients	467:474	arg1	disease					509:515	non-stenosis coronary heart disease	481:515	non-stenosis coronary heart disease (NCHD)	481:522	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	3	22	with	patients	467:474	arg1	NCHD					518:521	NCHD	518:521	NCHD	518:521	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	6	23	theme	higher	987:992	arg1	index					1002:1006	a significantly higher Shannon index	971:1006	a significantly higher Shannon index than that of the HT group	971:1032	The gut microbiota of the NCHD group had a significantly higher Shannon index than that of the HT group.
32793515	5	24	theme	significant	742:752	arg1	increase					754:761	a significant increase	740:761	a significant increase in lipopolysaccharides and white blood cells	740:806	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	5	25	from	increase	754:761	arg1	lipoprotein					840:850	high-density lipoprotein	827:850	high-density lipoprotein	827:850	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	5	25	from	increase	754:761	arg1	cells					802:806	white blood cells	790:806	white blood cells	790:806	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	5	25	from	increase	754:761	arg1	lipopolysaccharides					766:784	lipopolysaccharides	766:784	lipopolysaccharides	766:784	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	1	26	theme	Coronary	79:86	arg1	CHD					103:105	CHD	103:105	CHD	103:105	Coronary heart disease (CHD) is closely related to gut microbiota, which may be significantly affected by ethnicity and the environment.
32793515	1	26	theme	Coronary	79:86	arg1	disease					94:100	Coronary heart disease	79:100	Coronary heart disease (CHD)	79:106	Coronary heart disease (CHD) is closely related to gut microbiota, which may be significantly affected by ethnicity and the environment.
32793515	3	27	theme	gut	397:399	arg1	microbiota					401:410	gut microbiota	397:410	gut microbiota	397:410	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	1	28	theme	heart	88:92	arg1	CHD					103:105	CHD	103:105	CHD	103:105	Coronary heart disease (CHD) is closely related to gut microbiota, which may be significantly affected by ethnicity and the environment.
32793515	1	28	theme	heart	88:92	arg1	disease					94:100	Coronary heart disease	79:100	Coronary heart disease (CHD)	79:106	Coronary heart disease (CHD) is closely related to gut microbiota, which may be significantly affected by ethnicity and the environment.
32793515	5	29	from	decrease	815:822	arg1	lipoprotein					840:850	high-density lipoprotein	827:850	high-density lipoprotein	827:850	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	5	29	from	decrease	815:822	arg1	cells					802:806	white blood cells	790:806	white blood cells	790:806	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	5	29	from	decrease	815:822	arg1	lipopolysaccharides					766:784	lipopolysaccharides	766:784	lipopolysaccharides	766:784	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	0	30	theme	Microbiome	19:28	arg1	Alterations					0:10	Alterations	0:10	Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease	0:76	Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease.
32793515	9	31	theme	fatty	1630:1634	arg1	degradation					1641:1651	fatty acid degradation	1630:1651	fatty acid degradation	1630:1651	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	3	32	theme	heart	503:507	arg1	disease					509:515	non-stenosis coronary heart disease	481:515	non-stenosis coronary heart disease (NCHD)	481:522	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	3	32	theme	heart	503:507	arg1	NCHD					518:521	NCHD	518:521	NCHD	518:521	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	10	33	theme	family	1745:1750	arg1	factors					1789:1795	risk factors	1784:1795	risk factors	1784:1795	Additionally, occupation and a family history of CHD were shown to be risk factors and affected the gut microbiota in Tibetans.
32793515	10	33	theme	family	1745:1750	arg1	history					1752:1758	a family history	1743:1758	a family history of CHD	1743:1765	Additionally, occupation and a family history of CHD were shown to be risk factors and affected the gut microbiota in Tibetans.
32793515	4	34	theme	microbiome	564:573	arg1	alterations					541:551	the alterations	537:551	the alterations of the gut microbiome in CHD patients	537:589	We analyzed the alterations of the gut microbiome in CHD patients and investigated the relationship between these alterations and the pathological indicators.
32793515	0	35	theme	Gut	15:17	arg1	Microbiome					19:28	Gut Microbiome	15:28	Gut Microbiome	15:28	Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease.
32793515	3	36	with	Tibetans	428:435	arg1	disease					509:515	non-stenosis coronary heart disease	481:515	non-stenosis coronary heart disease (NCHD)	481:522	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	3	36	with	Tibetans	428:435	arg1	NCHD					518:521	NCHD	518:521	NCHD	518:521	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	10	37	theme	risk	1784:1787	arg1	history					1752:1758	a family history	1743:1758	a family history of CHD	1743:1765	Additionally, occupation and a family history of CHD were shown to be risk factors and affected the gut microbiota in Tibetans.
32793515	10	37	theme	risk	1784:1787	arg1	factors					1789:1795	risk factors	1784:1795	risk factors	1784:1795	Additionally, occupation and a family history of CHD were shown to be risk factors and affected the gut microbiota in Tibetans.
32793515	2	38	theme	patients	270:277	arg1	microbiome					244:253	the gut microbiome	236:253	the gut microbiome of Tibetan CHD patients living in the Qinghai-Tibet Plateau	236:313	Knowledge regarding the gut microbiome of Tibetan CHD patients living in the Qinghai-Tibet Plateau is very limited.
32793515	9	39	theme	genes	1465:1469	arg1	enrichment					1451:1460	enrichment	1451:1460	enrichment of genes	1451:1469	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	4	40	theme	gut	560:562	arg1	microbiome					564:573	the gut microbiome	556:573	the gut microbiome	556:573	We analyzed the alterations of the gut microbiome in CHD patients and investigated the relationship between these alterations and the pathological indicators.
32793515	0	41	theme	Tibetan	33:39	arg1	Patients					41:48	Tibetan Patients	33:48	Tibetan Patients With Coronary Heart Disease	33:76	Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease.
32793515	4	42	theme	CHD	578:580	arg1	patients					582:589	CHD patients	578:589	CHD patients	578:589	We analyzed the alterations of the gut microbiome in CHD patients and investigated the relationship between these alterations and the pathological indicators.
32793515	8	43	theme	HT	1318:1319	arg1	group					1321:1325	the HT group	1314:1325	the HT group	1314:1325	The Dialister genus was significantly lower and Blautia, Desulfovibrio, and Succinivibrio were significantly higher in abundance in CHD patients compared with the HT group, and the changes were significantly correlated with physiological indexes, such as increased lipopolysaccharides.
32793515	8	44	theme	Dialister	1159:1167	arg1	genus					1169:1173	The Dialister genus	1155:1173	The Dialister genus	1155:1173	The Dialister genus was significantly lower and Blautia, Desulfovibrio, and Succinivibrio were significantly higher in abundance in CHD patients compared with the HT group, and the changes were significantly correlated with physiological indexes, such as increased lipopolysaccharides.
32793515	8	44	theme	Dialister	1159:1167	arg1	lower					1193:1197	lower	1193:1197	lower	1193:1197	The Dialister genus was significantly lower and Blautia, Desulfovibrio, and Succinivibrio were significantly higher in abundance in CHD patients compared with the HT group, and the changes were significantly correlated with physiological indexes, such as increased lipopolysaccharides.
32793515	3	45	theme	healthy	420:426	arg1	Tibetans					428:435	23 healthy Tibetans	417:435	23 healthy Tibetans (HT)	417:440	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	3	45	theme	healthy	420:426	arg1	HT					438:439	HT	438:439	HT	438:439	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	8	46	theme	physiological	1379:1391	arg1	lipopolysaccharides					1420:1438	increased lipopolysaccharides	1410:1438	increased lipopolysaccharides	1410:1438	The Dialister genus was significantly lower and Blautia, Desulfovibrio, and Succinivibrio were significantly higher in abundance in CHD patients compared with the HT group, and the changes were significantly correlated with physiological indexes, such as increased lipopolysaccharides.
32793515	8	46	theme	physiological	1379:1391	arg1	indexes					1393:1399	physiological indexes	1379:1399	physiological indexes	1379:1399	The Dialister genus was significantly lower and Blautia, Desulfovibrio, and Succinivibrio were significantly higher in abundance in CHD patients compared with the HT group, and the changes were significantly correlated with physiological indexes, such as increased lipopolysaccharides.
32793515	6	47	theme	group	961:965	arg1	microbiota					938:947	The gut microbiota	930:947	The gut microbiota of the NCHD group	930:965	The gut microbiota of the NCHD group had a significantly higher Shannon index than that of the HT group.
32793515	9	48	theme	acid	1507:1510	arg1	metabolism					1512:1521	amino acid metabolism	1501:1521	amino acid metabolism	1501:1521	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	7	49	theme	Adonis	1035:1040	arg1	analysis					1042:1049	Adonis analysis	1035:1049	Adonis analysis	1035:1049	Adonis analysis showed that both microbial compositions and functions of the three groups were significantly separated.
32793515	10	50	theme	CHD	1763:1765	arg1	occupation					1728:1737	occupation	1728:1737	occupation	1728:1737	Additionally, occupation and a family history of CHD were shown to be risk factors and affected the gut microbiota in Tibetans.
32793515	10	50	theme	CHD	1763:1765	arg1	factors					1789:1795	risk factors	1784:1795	risk factors	1784:1795	Additionally, occupation and a family history of CHD were shown to be risk factors and affected the gut microbiota in Tibetans.
32793515	10	50	theme	CHD	1763:1765	arg1	history					1752:1758	a family history	1743:1758	a family history of CHD	1743:1765	Additionally, occupation and a family history of CHD were shown to be risk factors and affected the gut microbiota in Tibetans.
32793515	5	51	theme	trimethylamine	707:720	arg1	N-oxide					722:728	trimethylamine N-oxide	707:728	trimethylamine N-oxide	707:728	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	8	52	theme	increased	1410:1418	arg1	lipopolysaccharides					1420:1438	increased lipopolysaccharides	1410:1438	increased lipopolysaccharides	1410:1438	The Dialister genus was significantly lower and Blautia, Desulfovibrio, and Succinivibrio were significantly higher in abundance in CHD patients compared with the HT group, and the changes were significantly correlated with physiological indexes, such as increased lipopolysaccharides.
32793515	8	53	theme	CHD	1287:1289	arg1	patients					1291:1298	CHD patients	1287:1298	CHD patients	1287:1298	The Dialister genus was significantly lower and Blautia, Desulfovibrio, and Succinivibrio were significantly higher in abundance in CHD patients compared with the HT group, and the changes were significantly correlated with physiological indexes, such as increased lipopolysaccharides.
32793515	3	54	theme	physiological	368:380	arg1	parameters					382:391	the physiological parameters	364:391	the physiological parameters	364:391	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	9	55	theme	acid	1669:1672	arg1	metabolism					1674:1683	arachidonic acid metabolism	1657:1683	arachidonic acid metabolism	1657:1683	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	9	56	theme	arginine	1532:1539	arg1	biosynthesis					1541:1552	arginine biosynthesis	1532:1552	arginine biosynthesis	1532:1552	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	10	57	theme	gut	1814:1816	arg1	microbiota					1818:1827	the gut microbiota	1810:1827	the gut microbiota	1810:1827	Additionally, occupation and a family history of CHD were shown to be risk factors and affected the gut microbiota in Tibetans.
32793515	3	58	theme	CHD	446:448	arg1	patients					450:457	18 CHD patients	443:457	18 CHD patients	443:457	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	11	59	theme	CHD	1900:1902	arg1	understanding					1883:1895	the understanding	1879:1895	the understanding of CHD	1879:1902	Our study will provide insights into the understanding of CHD, leading to better diagnosis and treatment of Tibetan patients.
32793515	2	60	theme	gut	240:242	arg1	microbiome					244:253	the gut microbiome	236:253	the gut microbiome of Tibetan CHD patients living in the Qinghai-Tibet Plateau	236:313	Knowledge regarding the gut microbiome of Tibetan CHD patients living in the Qinghai-Tibet Plateau is very limited.
32793515	6	61	theme	HT	1025:1026	arg1	group					1028:1032	the HT group	1021:1032	the HT group	1021:1032	The gut microbiota of the NCHD group had a significantly higher Shannon index than that of the HT group.
32793515	5	62	theme	patients	886:893	arg1	blood					873:877	the blood	869:877	the blood of CHD patients	869:893	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	5	63	from	changes	696:702	arg1	N-oxide					722:728	trimethylamine N-oxide	707:728	trimethylamine N-oxide	707:728	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	3	64	theme	non-stenosis	481:492	arg1	disease					509:515	non-stenosis coronary heart disease	481:515	non-stenosis coronary heart disease (NCHD)	481:522	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	3	64	theme	non-stenosis	481:492	arg1	NCHD					518:521	NCHD	518:521	NCHD	518:521	In this study, we characterized the physiological parameters and gut microbiota from 23 healthy Tibetans (HT), 18 CHD patients, and 12 patients with non-stenosis coronary heart disease (NCHD).
32793515	2	65	theme	Qinghai-Tibet	293:305	arg1	Plateau					307:313	the Qinghai-Tibet Plateau	289:313	the Qinghai-Tibet Plateau	289:313	Knowledge regarding the gut microbiome of Tibetan CHD patients living in the Qinghai-Tibet Plateau is very limited.
32793515	11	66	dep	better	1916:1921	arg1	treatment					1937:1945	treatment	1937:1945	treatment	1937:1945	Our study will provide insights into the understanding of CHD, leading to better diagnosis and treatment of Tibetan patients.
32793515	11	66	dep	better	1916:1921	arg1	diagnosis					1923:1931	diagnosis	1923:1931	diagnosis	1923:1931	Our study will provide insights into the understanding of CHD, leading to better diagnosis and treatment of Tibetan patients.
32793515	0	67	theme	Heart	64:68	arg1	Disease					70:76	Coronary Heart Disease	55:76	Coronary Heart Disease	55:76	Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease.
32793515	9	68	theme	histidine	1558:1566	arg1	metabolism					1568:1577	histidine metabolism	1558:1577	histidine metabolism	1558:1577	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	0	69	with	Patients	41:48	arg1	Disease					70:76	Coronary Heart Disease	55:76	Coronary Heart Disease	55:76	Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease.
32793515	6	70	theme	gut	934:936	arg1	microbiota					938:947	The gut microbiota	930:947	The gut microbiota of the NCHD group	930:965	The gut microbiota of the NCHD group had a significantly higher Shannon index than that of the HT group.
32793515	0	71	theme	Coronary	55:62	arg1	Disease					70:76	Coronary Heart Disease	55:76	Coronary Heart Disease	55:76	Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease.
32793515	9	72	theme	metabolism	1599:1608	arg1	degradation					1641:1651	fatty acid degradation	1630:1651	fatty acid degradation	1630:1651	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	9	72	theme	metabolism	1599:1608	arg1	pathways					1610:1617	two lipid metabolism pathways	1589:1617	two lipid metabolism pathways	1589:1617	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	9	72	theme	metabolism	1599:1608	arg1	metabolism					1674:1683	arachidonic acid metabolism	1657:1683	arachidonic acid metabolism	1657:1683	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	7	73	theme	microbial	1068:1076	arg1	compositions					1078:1089	microbial compositions	1068:1089	microbial compositions	1068:1089	Adonis analysis showed that both microbial compositions and functions of the three groups were significantly separated.
32793515	5	74	theme	high-density	827:838	arg1	lipoprotein					840:850	high-density lipoprotein	827:850	high-density lipoprotein	827:850	We found no changes in trimethylamine N-oxide, however, a significant increase in lipopolysaccharides and white blood cells, and a decrease in high-density lipoprotein were observed in the blood of CHD patients, compared to that in the HT group.
32793515	9	75	theme	acid	1636:1639	arg1	degradation					1641:1651	fatty acid degradation	1630:1651	fatty acid degradation	1630:1651	Moreover, enrichment of genes decreased in four pathways of amino acid metabolism, such as arginine biosynthesis and histidine metabolism, although two lipid metabolism pathways, including fatty acid degradation and arachidonic acid metabolism, increased in the CHD group.
32793515	6	76	theme	NCHD	956:959	arg1	group					961:965	the NCHD group	952:965	the NCHD group	952:965	The gut microbiota of the NCHD group had a significantly higher Shannon index than that of the HT group.
32184142	0	0	theme	methylene	110:118	arg1	dye					125:127	cationic methylene blue dye	101:127	cationic methylene blue dye	101:127	Carboxymethyl cellulose/carboxylated graphene oxide composite microbeads for efficient adsorption of cationic methylene blue dye.
32184142	3	1	theme	adsorption	669:678	arg1	experiments					680:690	batch adsorption experiments	663:690	batch adsorption experiments	663:690	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	0	2	theme	cationic	101:108	arg1	dye					125:127	cationic methylene blue dye	101:127	cationic methylene blue dye	101:127	Carboxymethyl cellulose/carboxylated graphene oxide composite microbeads for efficient adsorption of cationic methylene blue dye.
32184142	6	3	with	cycles	1112:1117	arg1	properties					1142:1151	highly adsorption properties	1124:1151	highly adsorption properties	1124:1151	Besides, the fabricated adsorbent exposed also better reusability for nine repetitive cycles with highly adsorption properties.
32184142	4	4	theme	180.32 mg/g	830:840	arg1	capacity					818:825	a maximum adsorption capacity	797:825	a maximum adsorption capacity of 180.32 mg/g	797:840	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	1	5	theme	carboxymethyl	187:199	arg1	microbeads					217:226	carboxymethyl cellulose (CMC) microbeads	187:226	carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB)	187:339	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	4	6	with	isotherm	770:777	arg1	capacity					818:825	a maximum adsorption capacity	797:825	a maximum adsorption capacity of 180.32 mg/g	797:840	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	0	7	theme	dye	125:127	arg1	adsorption					87:96	efficient adsorption	77:96	efficient adsorption of cationic methylene blue dye	77:127	Carboxymethyl cellulose/carboxylated graphene oxide composite microbeads for efficient adsorption of cationic methylene blue dye.
32184142	5	8	theme	dye	925:927	arg1	adsorption					908:917	the adsorption	904:917	the adsorption of MB dye onto CMC/GOCOOH composite microbeads	904:964	Moreover, the adsorption of MB dye onto CMC/GOCOOH composite microbeads was an exothermic process with a maximum capacity at pH 10.
32184142	5	8	theme	dye	925:927	arg1	process					984:990	an exothermic process	970:990	an exothermic process	970:990	Moreover, the adsorption of MB dye onto CMC/GOCOOH composite microbeads was an exothermic process with a maximum capacity at pH 10.
32184142	1	9	theme	adsorptive	286:295	arg1	removal					297:303	the adsorptive removal	282:303	the adsorptive removal of cationic methylene blue dye (MB)	282:339	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	0	10	theme	blue	120:123	arg1	dye					125:127	cationic methylene blue dye	101:127	cationic methylene blue dye	101:127	Carboxymethyl cellulose/carboxylated graphene oxide composite microbeads for efficient adsorption of cationic methylene blue dye.
32184142	5	11	theme	CMC/GOCOOH	934:943	arg1	microbeads					955:964	CMC/GOCOOH composite microbeads	934:964	CMC/GOCOOH composite microbeads	934:964	Moreover, the adsorption of MB dye onto CMC/GOCOOH composite microbeads was an exothermic process with a maximum capacity at pH 10.
32184142	4	12	theme	process	733:739	arg1	data					710:713	The experimental data	693:713	The experimental data of the adsorption process	693:739	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	4	12	theme	process	733:739	arg1	fitted					751:756	fitted	751:756	fitted	751:756	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	3	13	theme	Various	479:485	arg1	parameters					487:496	Various parameters	479:496	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature	479:628	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	4	14	theme	adsorption	807:816	arg1	capacity					818:825	a maximum adsorption capacity	797:825	a maximum adsorption capacity of 180.32 mg/g	797:840	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	3	15	theme	MB	523:524	arg1	dye					526:528	MB dye	523:528	MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature	523:628	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	7	16	theme	aqueous	1302:1308	arg1	solutions					1310:1318	aqueous solutions	1302:1318	aqueous solutions	1302:1318	The gained results imply that the CMC/GOCOOH microbeads could be potentially applied as an effective and reusable adsorbent for MB dye removal from aqueous solutions.
32184142	1	17	theme	cellulose	201:209	arg1	microbeads					217:226	carboxymethyl cellulose (CMC) microbeads	187:226	carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB)	187:339	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	3	18	theme	experiments	680:690	arg1	series					653:658	a series	651:658	a series of batch adsorption experiments	651:690	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	4	19	theme	maximum	799:805	arg1	capacity					818:825	a maximum adsorption capacity	797:825	a maximum adsorption capacity of 180.32 mg/g	797:840	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	3	20	theme	dye	526:528	arg1	removal					512:518	the removal	508:518	the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature	508:628	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	2	21	theme	BET	440:442	arg1	tools					472:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	The developed CMC/GOCOOH composite microbeads were characterized by means of FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools.
32184142	5	22	from	pH 10	1019:1023	arg1	capacity					1007:1014	a maximum capacity	997:1014	a maximum capacity at pH 10	997:1023	Moreover, the adsorption of MB dye onto CMC/GOCOOH composite microbeads was an exothermic process with a maximum capacity at pH 10.
32184142	7	23	theme	MB	1282:1283	arg1	removal					1289:1295	MB dye removal	1282:1295	MB dye removal from aqueous solutions	1282:1318	The gained results imply that the CMC/GOCOOH microbeads could be potentially applied as an effective and reusable adsorbent for MB dye removal from aqueous solutions.
32184142	7	24	theme	gained	1158:1163	arg1	results					1165:1171	The gained results	1154:1171	The gained results	1154:1171	The gained results imply that the CMC/GOCOOH microbeads could be potentially applied as an effective and reusable adsorbent for MB dye removal from aqueous solutions.
32184142	1	25	theme	CMC	212:214	arg1	microbeads					217:226	carboxymethyl cellulose (CMC) microbeads	187:226	carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB)	187:339	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	3	26	theme	GOCOOH	552:557	arg1	pH					604:605	pH	604:605	pH	604:605	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	3	26	theme	GOCOOH	552:557	arg1	concentration					571:583	initial MB concentration	560:583	initial MB concentration	560:583	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	3	26	theme	GOCOOH	552:557	arg1	amount					542:547	the amount	538:547	the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature	538:628	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	3	26	theme	GOCOOH	552:557	arg1	temperature					618:628	medium temperature	611:628	medium temperature	611:628	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	3	26	theme	GOCOOH	552:557	arg1	GOCOOH					552:557	GOCOOH	552:557	GOCOOH	552:557	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	3	26	theme	GOCOOH	552:557	arg1	dosage					596:601	adsorbent dosage	586:601	adsorbent dosage	586:601	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	2	27	theme	XPS	435:437	arg1	tools					472:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	The developed CMC/GOCOOH composite microbeads were characterized by means of FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools.
32184142	1	28	theme	cationic	308:315	arg1	MB					337:338	MB	337:338	MB	337:338	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	1	28	theme	cationic	308:315	arg1	dye					332:334	cationic methylene blue dye	308:334	cationic methylene blue dye (MB)	308:339	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	4	29	theme	adsorption	722:731	arg1	process					733:739	the adsorption process	718:739	the adsorption process	718:739	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	2	30	theme	SEM	430:432	arg1	tools					472:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	The developed CMC/GOCOOH composite microbeads were characterized by means of FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools.
32184142	0	31	theme	graphene	37:44	arg1	microbeads					62:71	graphene oxide composite microbeads	37:71	graphene oxide composite microbeads for efficient adsorption of cationic methylene blue dye	37:127	Carboxymethyl cellulose/carboxylated graphene oxide composite microbeads for efficient adsorption of cationic methylene blue dye.
32184142	1	32	theme	methylene	317:325	arg1	MB					337:338	MB	337:338	MB	337:338	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	1	32	theme	methylene	317:325	arg1	dye					332:334	cationic methylene blue dye	308:334	cationic methylene blue dye (MB)	308:339	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	5	33	theme	composite	945:953	arg1	microbeads					955:964	CMC/GOCOOH composite microbeads	934:964	CMC/GOCOOH composite microbeads	934:964	Moreover, the adsorption of MB dye onto CMC/GOCOOH composite microbeads was an exothermic process with a maximum capacity at pH 10.
32184142	3	34	theme	medium	611:616	arg1	temperature					618:628	medium temperature	611:628	medium temperature	611:628	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	3	34	theme	medium	611:616	arg1	GOCOOH					552:557	GOCOOH	552:557	GOCOOH	552:557	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	2	35	theme	composite	367:375	arg1	microbeads					377:386	The developed CMC/GOCOOH composite microbeads	342:386	The developed CMC/GOCOOH composite microbeads	342:386	The developed CMC/GOCOOH composite microbeads were characterized by means of FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools.
32184142	6	36	theme	adsorption	1131:1140	arg1	properties					1142:1151	highly adsorption properties	1124:1151	highly adsorption properties	1124:1151	Besides, the fabricated adsorbent exposed also better reusability for nine repetitive cycles with highly adsorption properties.
32184142	2	37	theme	analysis	463:470	arg1	tools					472:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	The developed CMC/GOCOOH composite microbeads were characterized by means of FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools.
32184142	1	38	theme	blue	327:330	arg1	MB					337:338	MB	337:338	MB	337:338	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	1	38	theme	blue	327:330	arg1	dye					332:334	cationic methylene blue dye	308:334	cationic methylene blue dye (MB)	308:339	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	2	39	theme	TGA	425:427	arg1	tools					472:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	The developed CMC/GOCOOH composite microbeads were characterized by means of FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools.
32184142	3	40	theme	MB	568:569	arg1	concentration					571:583	initial MB concentration	560:583	initial MB concentration	560:583	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	3	40	theme	MB	568:569	arg1	GOCOOH					552:557	GOCOOH	552:557	GOCOOH	552:557	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	1	41	theme	carboxylated	241:252	arg1	GOCOOH					270:275	GOCOOH	270:275	GOCOOH	270:275	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	1	41	theme	carboxylated	241:252	arg1	oxide					263:267	carboxylated graphene oxide	241:267	carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB)	241:339	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	0	42	theme	composite	52:60	arg1	microbeads					62:71	graphene oxide composite microbeads	37:71	graphene oxide composite microbeads for efficient adsorption of cationic methylene blue dye	37:127	Carboxymethyl cellulose/carboxylated graphene oxide composite microbeads for efficient adsorption of cationic methylene blue dye.
32184142	1	43	theme	dye	332:334	arg1	removal					297:303	the adsorptive removal	282:303	the adsorptive removal of cationic methylene blue dye (MB)	282:339	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	2	44	theme	potential	453:461	arg1	tools					472:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	The developed CMC/GOCOOH composite microbeads were characterized by means of FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools.
32184142	0	45	theme	oxide	46:50	arg1	microbeads					62:71	graphene oxide composite microbeads	37:71	graphene oxide composite microbeads for efficient adsorption of cationic methylene blue dye	37:127	Carboxymethyl cellulose/carboxylated graphene oxide composite microbeads for efficient adsorption of cationic methylene blue dye.
32184142	1	46	theme	graphene	254:261	arg1	GOCOOH					270:275	GOCOOH	270:275	GOCOOH	270:275	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	1	46	theme	graphene	254:261	arg1	oxide					263:267	carboxylated graphene oxide	241:267	carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB)	241:339	An efficient composite adsorbent was fabricated based on carboxymethyl cellulose (CMC) microbeads incorporated carboxylated graphene oxide (GOCOOH) for the adsorptive removal of cationic methylene blue dye (MB).
32184142	2	47	theme	zeta	448:451	arg1	tools					472:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	The developed CMC/GOCOOH composite microbeads were characterized by means of FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools.
32184142	4	48	theme	order	873:877	arg1	model					887:891	the pseudo-second order kinetic model	855:891	the pseudo-second order kinetic model	855:891	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	5	49	with	process	984:990	arg1	capacity					1007:1014	a maximum capacity	997:1014	a maximum capacity at pH 10	997:1023	Moreover, the adsorption of MB dye onto CMC/GOCOOH composite microbeads was an exothermic process with a maximum capacity at pH 10.
32184142	5	50	theme	maximum	999:1005	arg1	capacity					1007:1014	a maximum capacity	997:1014	a maximum capacity at pH 10	997:1023	Moreover, the adsorption of MB dye onto CMC/GOCOOH composite microbeads was an exothermic process with a maximum capacity at pH 10.
32184142	6	51	theme	repetitive	1101:1110	arg1	cycles					1112:1117	nine repetitive cycles	1096:1117	nine repetitive cycles with highly adsorption properties	1096:1151	Besides, the fabricated adsorbent exposed also better reusability for nine repetitive cycles with highly adsorption properties.
32184142	2	52	theme	CMC/GOCOOH	356:365	arg1	microbeads					377:386	The developed CMC/GOCOOH composite microbeads	342:386	The developed CMC/GOCOOH composite microbeads	342:386	The developed CMC/GOCOOH composite microbeads were characterized by means of FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools.
32184142	2	53	theme	FTIR	419:422	arg1	tools					472:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools	419:476	The developed CMC/GOCOOH composite microbeads were characterized by means of FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools.
32184142	4	54	theme	pseudo-second	859:871	arg1	model					887:891	the pseudo-second order kinetic model	855:891	the pseudo-second order kinetic model	855:891	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	3	55	theme	initial	560:566	arg1	concentration					571:583	initial MB concentration	560:583	initial MB concentration	560:583	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	3	55	theme	initial	560:566	arg1	GOCOOH					552:557	GOCOOH	552:557	GOCOOH	552:557	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	2	56	theme	developed	346:354	arg1	microbeads					377:386	The developed CMC/GOCOOH composite microbeads	342:386	The developed CMC/GOCOOH composite microbeads	342:386	The developed CMC/GOCOOH composite microbeads were characterized by means of FTIR, TGA, SEM, XPS, BET and zeta potential analysis tools.
32184142	4	57	theme	Langmuir	761:768	arg1	isotherm					770:777	Langmuir isotherm	761:777	Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g	761:840	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	4	57	theme	Langmuir	761:768	arg1	R2 = 0.998					780:789	R2 = 0.998	780:789	R2 = 0.998	780:789	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	4	58	theme	experimental	697:708	arg1	data					710:713	The experimental data	693:713	The experimental data of the adsorption process	693:739	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	4	58	theme	experimental	697:708	arg1	fitted					751:756	fitted	751:756	fitted	751:756	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	5	59	theme	MB	922:923	arg1	dye					925:927	MB dye	922:927	MB dye	922:927	Moreover, the adsorption of MB dye onto CMC/GOCOOH composite microbeads was an exothermic process with a maximum capacity at pH 10.
32184142	4	60	theme	kinetic	879:885	arg1	model					887:891	the pseudo-second order kinetic model	855:891	the pseudo-second order kinetic model	855:891	The experimental data of the adsorption process were more fitted to Langmuir isotherm (R2 = 0.998) with a maximum adsorption capacity of 180.32 mg/g and followed the pseudo-second order kinetic model.
32184142	7	61	dep	effective	1245:1253	arg1	adsorbent					1268:1276	adsorbent	1268:1276	adsorbent	1268:1276	The gained results imply that the CMC/GOCOOH microbeads could be potentially applied as an effective and reusable adsorbent for MB dye removal from aqueous solutions.
32184142	7	62	theme	dye	1285:1287	arg1	removal					1289:1295	MB dye removal	1282:1295	MB dye removal from aqueous solutions	1282:1318	The gained results imply that the CMC/GOCOOH microbeads could be potentially applied as an effective and reusable adsorbent for MB dye removal from aqueous solutions.
32184142	5	63	theme	exothermic	973:982	arg1	adsorption					908:917	the adsorption	904:917	the adsorption of MB dye onto CMC/GOCOOH composite microbeads	904:964	Moreover, the adsorption of MB dye onto CMC/GOCOOH composite microbeads was an exothermic process with a maximum capacity at pH 10.
32184142	5	63	theme	exothermic	973:982	arg1	process					984:990	an exothermic process	970:990	an exothermic process	970:990	Moreover, the adsorption of MB dye onto CMC/GOCOOH composite microbeads was an exothermic process with a maximum capacity at pH 10.
32184142	7	64	from	solutions	1310:1318	arg1	removal					1289:1295	MB dye removal	1282:1295	MB dye removal from aqueous solutions	1282:1318	The gained results imply that the CMC/GOCOOH microbeads could be potentially applied as an effective and reusable adsorbent for MB dye removal from aqueous solutions.
32184142	0	65	theme	efficient	77:85	arg1	adsorption					87:96	efficient adsorption	77:96	efficient adsorption of cationic methylene blue dye	77:127	Carboxymethyl cellulose/carboxylated graphene oxide composite microbeads for efficient adsorption of cationic methylene blue dye.
32184142	3	66	theme	batch	663:667	arg1	experiments					680:690	batch adsorption experiments	663:690	batch adsorption experiments	663:690	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	3	67	theme	adsorbent	586:594	arg1	dosage					596:601	adsorbent dosage	586:601	adsorbent dosage	586:601	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	3	67	theme	adsorbent	586:594	arg1	GOCOOH					552:557	GOCOOH	552:557	GOCOOH	552:557	Various parameters affecting the removal of MB dye such as the amount of GOCOOH, initial MB concentration, adsorbent dosage, pH and medium temperature were optimized using a series of batch adsorption experiments.
32184142	6	68	theme	better	1073:1078	arg1	reusability					1080:1090	better reusability	1073:1090	better reusability for nine repetitive cycles with highly adsorption properties	1073:1151	Besides, the fabricated adsorbent exposed also better reusability for nine repetitive cycles with highly adsorption properties.
32184142	7	69	theme	CMC/GOCOOH	1188:1197	arg1	reusable					1259:1266	reusable	1259:1266	reusable	1259:1266	The gained results imply that the CMC/GOCOOH microbeads could be potentially applied as an effective and reusable adsorbent for MB dye removal from aqueous solutions.
32184142	7	69	theme	CMC/GOCOOH	1188:1197	arg1	effective					1245:1253	effective	1245:1253	effective	1245:1253	The gained results imply that the CMC/GOCOOH microbeads could be potentially applied as an effective and reusable adsorbent for MB dye removal from aqueous solutions.
32184142	7	69	theme	CMC/GOCOOH	1188:1197	arg1	microbeads					1199:1208	the CMC/GOCOOH microbeads	1184:1208	the CMC/GOCOOH microbeads	1184:1208	The gained results imply that the CMC/GOCOOH microbeads could be potentially applied as an effective and reusable adsorbent for MB dye removal from aqueous solutions.
34649671	6	0	theme	structural	861:870	arg1	characteristics					872:886	different structural characteristics	851:886	different structural characteristics	851:886	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	4	1	theme	mycelium	580:587	arg1	density					589:595	mycelium density	580:595	mycelium density	580:595	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	10	2	theme	fungus	1506:1511	arg1	growth					1513:1518	the fungus growth	1502:1518	the fungus growth	1502:1518	The highly cellulosic HS from VC regulate the fungus growth at later times and its biological performance.
34649671	10	3	from	VC	1490:1491	arg1	HS					1482:1483	The highly cellulosic HS	1460:1483	The highly cellulosic HS from VC	1460:1491	The highly cellulosic HS from VC regulate the fungus growth at later times and its biological performance.
34649671	6	4	theme	low	988:990	arg1	hydrophobicity					992:1005	low hydrophobicity	988:1005	low hydrophobicity	988:1005	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	6	5	theme	90	1014:1015	arg1	%					1016:1016	%	1016:1016	%	1016:1016	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	10	6	theme	biological	1543:1552	arg1	performance					1554:1564	its biological performance	1539:1564	its biological performance	1539:1564	The highly cellulosic HS from VC regulate the fungus growth at later times and its biological performance.
34649671	7	7	theme	%	1229:1229	arg1	carbon					1211:1216	lignin carbon	1204:1216	lignin carbon of up to 80%	1204:1229	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	8	8	theme	C-cellulosic	1294:1305	arg1	balance					1320:1326	the C-cellulosic and C-lignin balance	1290:1326	the C-cellulosic and C-lignin balance	1290:1326	The results showed that P. eryngii growth is dependent on the C-cellulosic and C-lignin balance.
34649671	1	9	dep	fungi	138:142	arg1	eryngii					155:161	Pleurotus eryngii	145:161	Pleurotus eryngii	145:161	White-rot fungi (Pleurotus eryngii) are decomposers of lignocellulosic substrates.
34649671	8	10	theme	P. eryngii	1256:1265	arg1	growth					1267:1272	P. eryngii growth	1256:1272	P. eryngii growth	1256:1272	The results showed that P. eryngii growth is dependent on the C-cellulosic and C-lignin balance.
34649671	0	11	theme	tropical	110:117	arg1	climate					119:125	a tropical climate	108:125	a tropical climate	108:125	Environmental implications of the organic matter structure for white-rot fungus Pleurotus eryngii growth in a tropical climate.
34649671	5	12	theme	chemometrics	813:824	arg1	analysis					826:833	chemometrics analysis	813:833	chemometrics analysis	813:833	Both HS were characterized by CP/MAS 13C NMR spectroscopy associated with chemometrics analysis.
34649671	2	13	theme	growth	292:297	arg1	structure					240:248	the structure	236:248	the structure of humified organic matter and P. eryngii growth	236:297	The relationship between the structure of humified organic matter and P. eryngii growth, is poorly understood.
34649671	0	14	theme	structure	49:57	arg1	implications					14:25	Environmental implications	0:25	Environmental implications of the organic matter structure for white-rot fungus Pleurotus eryngii growth in a tropical climate	0:125	Environmental implications of the organic matter structure for white-rot fungus Pleurotus eryngii growth in a tropical climate.
34649671	4	15	theme	Fungus	501:506	arg1	growth					508:513	Fungus growth	501:513	Fungus growth	501:513	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	8	16	theme	C-lignin	1311:1318	arg1	balance					1320:1326	the C-cellulosic and C-lignin balance	1290:1326	the C-cellulosic and C-lignin balance	1290:1326	The results showed that P. eryngii growth is dependent on the C-cellulosic and C-lignin balance.
34649671	6	17	from	proportion	1018:1027	arg1	composition					1070:1080	the composition	1066:1080	the composition	1066:1080	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	2	18	theme	P. eryngii	281:290	arg1	growth					292:297	P. eryngii growth	281:297	P. eryngii growth	281:297	The relationship between the structure of humified organic matter and P. eryngii growth, is poorly understood.
34649671	10	19	theme	later	1523:1527	arg1	times					1529:1533	later times	1523:1533	later times	1523:1533	The highly cellulosic HS from VC regulate the fungus growth at later times and its biological performance.
34649671	5	20	theme	13C	776:778	arg1	spectroscopy					784:795	CP/MAS 13C NMR spectroscopy	769:795	CP/MAS 13C NMR spectroscopy associated with chemometrics analysis	769:833	Both HS were characterized by CP/MAS 13C NMR spectroscopy associated with chemometrics analysis.
34649671	6	21	theme	functionalized	943:956	arg1	C-aliphatics					958:969	functionalized C-aliphatics	943:969	functionalized C-aliphatics (carbohydrates)	943:985	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	6	21	theme	functionalized	943:956	arg1	carbohydrates					972:984	carbohydrates	972:984	carbohydrates	972:984	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	6	22	from	hydrophobicity	992:1005	arg1	composition					1070:1080	the composition	1066:1080	the composition	1066:1080	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	7	23	theme	lignin	1204:1209	arg1	carbon					1211:1216	lignin carbon	1204:1216	lignin carbon of up to 80%	1204:1229	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	9	24	theme	biological	1436:1445	arg1	performance					1447:1457	the biological performance	1432:1457	the biological performance	1432:1457	HS extracted from lignin-rich peat regulates the fungus growth at initial times and sometimes inhibits the biological performance.
34649671	0	25	theme	Environmental	0:12	arg1	implications					14:25	Environmental implications	0:25	Environmental implications of the organic matter structure for white-rot fungus Pleurotus eryngii growth in a tropical climate	0:125	Environmental implications of the organic matter structure for white-rot fungus Pleurotus eryngii growth in a tropical climate.
34649671	4	26	theme	dry	561:563	arg1	mass					574:577	fresh and dry mycelium mass	551:577	fresh and dry mycelium mass	551:577	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	1	27	theme	lignocellulosic	183:197	arg1	substrates					199:208	lignocellulosic substrates	183:208	lignocellulosic substrates	183:208	White-rot fungi (Pleurotus eryngii) are decomposers of lignocellulosic substrates.
34649671	5	28	theme	NMR	780:782	arg1	spectroscopy					784:795	CP/MAS 13C NMR spectroscopy	769:795	CP/MAS 13C NMR spectroscopy associated with chemometrics analysis	769:833	Both HS were characterized by CP/MAS 13C NMR spectroscopy associated with chemometrics analysis.
34649671	0	29	dep	fungus	73:78	arg1	eryngii					90:96	eryngii	90:96	eryngii	90:96	Environmental implications of the organic matter structure for white-rot fungus Pleurotus eryngii growth in a tropical climate.
34649671	1	30	theme	substrates	199:208	arg1	fungi					138:142	White-rot fungi	128:142	White-rot fungi (Pleurotus eryngii)	128:162	White-rot fungi (Pleurotus eryngii) are decomposers of lignocellulosic substrates.
34649671	1	30	theme	substrates	199:208	arg1	decomposers					168:178	decomposers	168:178	decomposers of lignocellulosic substrates	168:208	White-rot fungi (Pleurotus eryngii) are decomposers of lignocellulosic substrates.
34649671	6	31	theme	C-aliphatics	958:969	arg1	predominance					927:938	a predominance	925:938	a predominance of functionalized C-aliphatics (carbohydrates)	925:985	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	6	31	theme	C-aliphatics	958:969	arg1	hydrophobicity					992:1005	low hydrophobicity	988:1005	low hydrophobicity	988:1005	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	6	31	theme	C-aliphatics	958:969	arg1	proportion					1018:1027	a 90% proportion	1012:1027	a 90% proportion of cellulose/hemicellulose carbon in the composition	1012:1080	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	10	32	theme	cellulosic	1471:1480	arg1	HS					1482:1483	The highly cellulosic HS	1460:1483	The highly cellulosic HS from VC	1460:1491	The highly cellulosic HS from VC regulate the fungus growth at later times and its biological performance.
34649671	6	33	theme	different	851:859	arg1	characteristics					872:886	different structural characteristics	851:886	different structural characteristics	851:886	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	7	34	dep	80	1227:1228	arg1	to					1224:1225	to	1224:1225	to	1224:1225	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	9	35	theme	initial	1395:1401	arg1	times					1403:1407	initial times	1395:1407	initial times	1395:1407	HS extracted from lignin-rich peat regulates the fungus growth at initial times and sometimes inhibits the biological performance.
34649671	3	36	theme	humified	476:483	arg1	matter					493:498	humified organic matter	476:498	humified organic matter	476:498	This study aimed to evaluate the relationship between the growth and development of white-rot fungi (P. eryngii) in two structurally different sources of humified organic matter.
34649671	0	37	theme	matter	42:47	arg1	structure					49:57	the organic matter structure	30:57	the organic matter structure	30:57	Environmental implications of the organic matter structure for white-rot fungus Pleurotus eryngii growth in a tropical climate.
34649671	4	38	theme	mycelium	565:572	arg1	mass					574:577	fresh and dry mycelium mass	551:577	fresh and dry mycelium mass	551:577	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	7	39	theme	higher	1161:1166	arg1	hydrophobicity					1168:1181	higher hydrophobicity	1161:1181	higher hydrophobicity	1161:1181	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	6	40	attach	predominance	927:938	arg2	carbohydrates					972:984	carbohydrates	972:984	carbohydrates	972:984	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	6	40	attach	predominance	927:938	arg2	C-aliphatics					958:969	functionalized C-aliphatics	943:969	functionalized C-aliphatics (carbohydrates)	943:985	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	6	40	attach	predominance	927:938	arg2	carbon					1056:1061	cellulose/hemicellulose carbon	1032:1061	cellulose/hemicellulose carbon	1032:1061	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	6	40	attach	predominance	927:938	arg1	composition					1070:1080	the composition	1066:1080	the composition	1066:1080	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	6	41	theme	carbon	1056:1061	arg1	predominance					927:938	a predominance	925:938	a predominance of functionalized C-aliphatics (carbohydrates)	925:985	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	6	41	theme	carbon	1056:1061	arg1	hydrophobicity					992:1005	low hydrophobicity	988:1005	low hydrophobicity	988:1005	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	6	41	theme	carbon	1056:1061	arg1	proportion					1018:1027	a 90% proportion	1012:1027	a 90% proportion of cellulose/hemicellulose carbon in the composition	1012:1080	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	3	42	theme	different	455:463	arg1	sources					465:471	two structurally different sources	438:471	two structurally different sources of humified organic matter	438:498	This study aimed to evaluate the relationship between the growth and development of white-rot fungi (P. eryngii) in two structurally different sources of humified organic matter.
34649671	0	43	theme	organic	34:40	arg1	structure					49:57	the organic matter structure	30:57	the organic matter structure	30:57	Environmental implications of the organic matter structure for white-rot fungus Pleurotus eryngii growth in a tropical climate.
34649671	7	44	theme	lignin	1142:1147	arg1	C-aromatics					1129:1139	C-aromatics	1129:1139	C-aromatics (lignin fragments)	1129:1158	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	7	44	theme	lignin	1142:1147	arg1	fragments					1149:1157	lignin fragments	1142:1157	lignin fragments	1142:1157	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	9	45	theme	fungus	1378:1383	arg1	growth					1385:1390	the fungus growth	1374:1390	the fungus growth	1374:1390	HS extracted from lignin-rich peat regulates the fungus growth at initial times and sometimes inhibits the biological performance.
34649671	6	46	theme	%	1016:1016	arg1	proportion					1018:1027	a 90% proportion	1012:1027	a 90% proportion of cellulose/hemicellulose carbon in the composition	1012:1080	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	3	47	theme	white-rot	406:414	arg1	fungi					416:420	white-rot fungi	406:420	white-rot fungi (P. eryngii)	406:433	This study aimed to evaluate the relationship between the growth and development of white-rot fungi (P. eryngii) in two structurally different sources of humified organic matter.
34649671	3	47	theme	white-rot	406:414	arg1	P. eryngii					423:432	P. eryngii	423:432	P. eryngii	423:432	This study aimed to evaluate the relationship between the growth and development of white-rot fungi (P. eryngii) in two structurally different sources of humified organic matter.
34649671	4	48	theme	mycelium	532:539	arg1	diameter					541:548	mycelium diameter	532:548	mycelium diameter	532:548	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	5	49	theme	CP/MAS	769:774	arg1	spectroscopy					784:795	CP/MAS 13C NMR spectroscopy	769:795	CP/MAS 13C NMR spectroscopy associated with chemometrics analysis	769:833	Both HS were characterized by CP/MAS 13C NMR spectroscopy associated with chemometrics analysis.
34649671	7	50	theme	carbon	1211:1216	arg1	hydrophobicity					1168:1181	higher hydrophobicity	1161:1181	higher hydrophobicity	1161:1181	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	7	50	theme	carbon	1211:1216	arg1	proportion					1190:1199	a proportion	1188:1199	a proportion of lignin carbon of up to 80%	1188:1229	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	7	50	theme	carbon	1211:1216	arg1	predominance					1113:1124	a predominance	1111:1124	a predominance of C-aromatics (lignin fragments)	1111:1158	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	3	51	theme	fungi	416:420	arg1	development					391:401	development	391:401	development	391:401	This study aimed to evaluate the relationship between the growth and development of white-rot fungi (P. eryngii) in two structurally different sources of humified organic matter.
34649671	3	51	theme	fungi	416:420	arg1	growth					380:385	growth	380:385	growth	380:385	This study aimed to evaluate the relationship between the growth and development of white-rot fungi (P. eryngii) in two structurally different sources of humified organic matter.
34649671	4	52	theme	fresh	551:555	arg1	mass					574:577	fresh and dry mycelium mass	551:577	fresh and dry mycelium mass	551:577	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	4	53	with	experiments	638:648	arg1	application					659:669	the application	655:669	the application of humic substances (HS) extracted from vermicompost (VC) and peat	655:736	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	4	54	dep	growth	508:513	arg1	density					589:595	mycelium density	580:595	mycelium density	580:595	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	4	54	dep	growth	508:513	arg1	yield					613:617	biological yield	602:617	biological yield	602:617	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	4	54	dep	growth	508:513	arg1	diameter					541:548	mycelium diameter	532:548	mycelium diameter	532:548	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	4	54	dep	growth	508:513	arg1	mass					574:577	fresh and dry mycelium mass	551:577	fresh and dry mycelium mass	551:577	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	7	55	theme	C-aromatics	1129:1139	arg1	hydrophobicity					1168:1181	higher hydrophobicity	1161:1181	higher hydrophobicity	1161:1181	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	7	55	theme	C-aromatics	1129:1139	arg1	proportion					1190:1199	a proportion	1188:1199	a proportion of lignin carbon of up to 80%	1188:1229	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	7	55	theme	C-aromatics	1129:1139	arg1	predominance					1113:1124	a predominance	1111:1124	a predominance of C-aromatics (lignin fragments)	1111:1158	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	1	56	theme	White-rot	128:136	arg1	fungi					138:142	White-rot fungi	128:142	White-rot fungi (Pleurotus eryngii)	128:162	White-rot fungi (Pleurotus eryngii) are decomposers of lignocellulosic substrates.
34649671	1	56	theme	White-rot	128:136	arg1	decomposers					168:178	decomposers	168:178	decomposers of lignocellulosic substrates	168:208	White-rot fungi (Pleurotus eryngii) are decomposers of lignocellulosic substrates.
34649671	9	57	theme	lignin-rich	1347:1357	arg1	peat					1359:1362	lignin-rich peat	1347:1362	lignin-rich peat	1347:1362	HS extracted from lignin-rich peat regulates the fungus growth at initial times and sometimes inhibits the biological performance.
34649671	4	58	theme	biological	602:611	arg1	yield					613:617	biological yield	602:617	biological yield	602:617	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	6	59	from	predominance	927:938	arg1	composition					1070:1080	the composition	1066:1080	the composition	1066:1080	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	2	60	theme	matter	270:275	arg1	structure					240:248	the structure	236:248	the structure of humified organic matter and P. eryngii growth	236:297	The relationship between the structure of humified organic matter and P. eryngii growth, is poorly understood.
34649671	3	61	theme	matter	493:498	arg1	sources					465:471	two structurally different sources	438:471	two structurally different sources of humified organic matter	438:498	This study aimed to evaluate the relationship between the growth and development of white-rot fungi (P. eryngii) in two structurally different sources of humified organic matter.
34649671	3	62	theme	organic	485:491	arg1	matter					493:498	humified organic matter	476:498	humified organic matter	476:498	This study aimed to evaluate the relationship between the growth and development of white-rot fungi (P. eryngii) in two structurally different sources of humified organic matter.
34649671	0	63	theme	fungus	73:78	arg1	growth					98:103	white-rot fungus Pleurotus eryngii growth	63:103	white-rot fungus Pleurotus eryngii growth in a tropical climate	63:125	Environmental implications of the organic matter structure for white-rot fungus Pleurotus eryngii growth in a tropical climate.
34649671	0	64	from	growth	98:103	arg1	climate					119:125	a tropical climate	108:125	a tropical climate	108:125	Environmental implications of the organic matter structure for white-rot fungus Pleurotus eryngii growth in a tropical climate.
34649671	2	65	theme	organic	262:268	arg1	matter					270:275	humified organic matter	253:275	humified organic matter	253:275	The relationship between the structure of humified organic matter and P. eryngii growth, is poorly understood.
34649671	6	66	theme	cellulose/hemicellulose	1032:1054	arg1	carbon					1056:1061	cellulose/hemicellulose carbon	1032:1061	cellulose/hemicellulose carbon	1032:1061	The HS present different structural characteristics, with those extracted from VC having a predominance of functionalized C-aliphatics (carbohydrates), low hydrophobicity, and a 90% proportion of cellulose/hemicellulose carbon in the composition.
34649671	4	67	theme	substances	680:689	arg1	application					659:669	the application	655:669	the application of humic substances (HS) extracted from vermicompost (VC) and peat	655:736	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	0	68	theme	white-rot	63:71	arg1	growth					98:103	white-rot fungus Pleurotus eryngii growth	63:103	white-rot fungus Pleurotus eryngii growth in a tropical climate	63:125	Environmental implications of the organic matter structure for white-rot fungus Pleurotus eryngii growth in a tropical climate.
34649671	2	69	theme	humified	253:260	arg1	matter					270:275	humified organic matter	253:275	humified organic matter	253:275	The relationship between the structure of humified organic matter and P. eryngii growth, is poorly understood.
34649671	4	70	theme	humic	674:678	arg1	HS					692:693	HS	692:693	HS	692:693	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	4	70	theme	humic	674:678	arg1	substances					680:689	humic substances	674:689	humic substances (HS) extracted from vermicompost (VC) and peat	674:736	Fungus growth and development (mycelium diameter, fresh and dry mycelium mass, mycelium density, and biological yield) were evaluated in experiments with the application of humic substances (HS) extracted from vermicompost (VC) and peat.
34649671	7	71	contain	have	1106:1109	arg2	predominance					1113:1124	a predominance	1111:1124	a predominance of C-aromatics (lignin fragments)	1111:1158	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	7	71	contain	have	1106:1109	arg2	hydrophobicity					1168:1181	higher hydrophobicity	1161:1181	higher hydrophobicity	1161:1181	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	7	71	contain	have	1106:1109	arg1	HS					1083:1084	HS	1083:1084	HS extracted from peat	1083:1104	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
34649671	7	71	contain	have	1106:1109	arg2	proportion					1190:1199	a proportion	1188:1199	a proportion of lignin carbon of up to 80%	1188:1229	HS extracted from peat have a predominance of C-aromatics (lignin fragments), higher hydrophobicity, and a proportion of lignin carbon of up to 80%.
33558961	1	0	theme	baby	266:269	arg1	formulas					271:278	baby formulas	266:278	baby formulas	266:278	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	6	1	theme	separation	965:974	arg1	matrix					976:981	The conventionally used carbohydrate separation matrix	928:981	The conventionally used carbohydrate separation matrix	928:981	The conventionally used carbohydrate separation matrix was applied for the in-process analysis of bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose.
33558961	3	2	theme	charge	582:587	arg1	ratios					589:594	charge ratios	582:594	charge ratios	582:594	Capillary gel electrophoresis primarily separates analyte molecules based on their hydrodynamic volume to charge ratios, thus, offers excellent resolution for most of such otherwise difficult-to-separate isomers.
33558961	9	3	theme	high	1515:1518	arg1	resolution					1520:1529	high resolution	1515:1529	high resolution	1515:1529	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	1	4	used	utilized	293:300	arg2	they					233:236	they	233:236	they	233:236	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	1	4	used	utilized	293:300	arg2	supplements					313:323	dietary supplements	305:323	dietary supplements for all age groups	305:342	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	1	4	used	utilized	293:300	arg2	ingredients					251:261	key ingredients	247:261	key ingredients in baby formulas	247:278	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	9	5	dep	additive	1681:1688	arg1	control					1715:1721	manufacturing in-process control	1690:1721	manufacturing in-process control	1690:1721	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	7	6	theme	production	1273:1282	arg1	flask					1220:1224	a shake flask and fermentation approach	1212:1250	flask	1220:1224	The other example showed the suitability of the method for the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production.
33558961	7	6	theme	production	1273:1282	arg1	approach					1243:1250	a shake flask and fermentation approach	1212:1250	approach	1243:1250	The other example showed the suitability of the method for the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production.
33558961	5	7	theme	control	910:916	arg1	examples					918:925	selected analytical in-process control examples	879:925	selected analytical in-process control examples	879:925	The relevant respective separation matrices were then applied to selected analytical in-process control examples.
33558961	7	8	theme	2'-fucosyllactose	1255:1271	arg1	production					1273:1282	2'-fucosyllactose production	1255:1282	2'-fucosyllactose production	1255:1282	The other example showed the suitability of the method for the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production.
33558961	9	9	theme	migration	1545:1553	arg1	time					1555:1558	excellent migration time	1535:1558	excellent migration time	1535:1558	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	8	10	theme	latter	1293:1298	arg1	instance					1300:1307	this latter instance	1288:1307	this latter instance	1288:1307	In this latter instance, borate complexation was utilized to efficiently separate the 2'- and 3-fucosylated lactose positional isomers.
33558961	6	11	theme	production	1044:1053	arg1	analysis					1014:1021	the in-process analysis	999:1021	the in-process analysis of bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose	999:1116	The conventionally used carbohydrate separation matrix was applied for the in-process analysis of bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose.
33558961	7	12	theme	method	1167:1172	arg1	suitability					1148:1158	the suitability	1144:1158	the suitability of the method for the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production	1144:1282	The other example showed the suitability of the method for the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production.
33558961	7	13	theme	approach	1243:1250	arg1	control					1201:1207	the in vivo in-process control	1178:1207	the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production	1178:1282	The other example showed the suitability of the method for the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production.
33558961	5	14	theme	analytical	888:897	arg1	examples					918:925	selected analytical in-process control examples	879:925	selected analytical in-process control examples	879:925	The relevant respective separation matrices were then applied to selected analytical in-process control examples.
33558961	6	15	theme	in-process	1003:1012	arg1	analysis					1014:1021	the in-process analysis	999:1021	the in-process analysis of bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose	999:1116	The conventionally used carbohydrate separation matrix was applied for the in-process analysis of bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose.
33558961	8	16	theme	lactose	1393:1399	arg1	isomers					1412:1418	the 2'- and 3-fucosylated lactose positional isomers	1367:1418	the 2'- and 3-fucosylated lactose positional isomers	1367:1418	In this latter instance, borate complexation was utilized to efficiently separate the 2'- and 3-fucosylated lactose positional isomers.
33558961	1	17	from	ingredients	251:261	arg1	formulas					271:278	baby formulas	266:278	baby formulas	266:278	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	3	18	theme	excellent	610:618	arg1	resolution					620:629	excellent resolution	610:629	excellent resolution for most of such otherwise difficult-to-separate isomers	610:686	Capillary gel electrophoresis primarily separates analyte molecules based on their hydrodynamic volume to charge ratios, thus, offers excellent resolution for most of such otherwise difficult-to-separate isomers.
33558961	7	19	theme	flask	1220:1224	arg1	control					1201:1207	the in vivo in-process control	1178:1207	the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production	1178:1282	The other example showed the suitability of the method for the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production.
33558961	1	20	theme	human	153:157	arg1	oligosaccharides					164:179	human milk oligosaccharides	153:179	human milk oligosaccharides (HMOs)	153:186	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	1	20	theme	human	153:157	arg1	HMOs					182:185	HMOs	182:185	HMOs	182:185	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	4	21	theme	available	720:728	arg1	compositions					734:745	two commercially available gel compositions	703:745	two commercially available gel compositions	703:745	In this work, two commercially available gel compositions were evaluated on the analysis of a mixture of ten synthetic HMOs.
33558961	0	22	theme	oligosaccharides	59:74	arg1	analysis					36:43	Rapid capillary gel electrophoresis analysis	0:43	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.	0:126	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.
33558961	8	23	gly	3-fucosylated	1379:1391	arg1	isomers					1412:1418	the 2'- and 3-fucosylated lactose positional isomers	1367:1418	the 2'- and 3-fucosylated lactose positional isomers	1367:1418	In this latter instance, borate complexation was utilized to efficiently separate the 2'- and 3-fucosylated lactose positional isomers.
33558961	1	24	theme	oligosaccharides	164:179	arg1	production					139:148	Industrial production	128:148	Industrial production of human milk oligosaccharides (HMOs)	128:186	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	6	25	theme	lacto-N-tetraose	1076:1091	arg1	production					1044:1053	bacteria-mediated production	1026:1053	bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose	1026:1116	The conventionally used carbohydrate separation matrix was applied for the in-process analysis of bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose.
33558961	0	26	theme	manufacturing	94:106	arg1	control					119:125	food additive manufacturing in-process control	80:125	food additive manufacturing in-process control	80:125	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.
33558961	6	27	theme	3-fucosyllactose	1058:1073	arg1	production					1044:1053	bacteria-mediated production	1026:1053	bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose	1026:1116	The conventionally used carbohydrate separation matrix was applied for the in-process analysis of bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose.
33558961	0	28	theme	milk	54:57	arg1	oligosaccharides					59:74	human milk oligosaccharides	48:74	human milk oligosaccharides	48:74	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.
33558961	4	29	theme	HMOs	808:811	arg1	mixture					783:789	a mixture	781:789	a mixture of ten synthetic HMOs	781:811	In this work, two commercially available gel compositions were evaluated on the analysis of a mixture of ten synthetic HMOs.
33558961	6	30	theme	used	947:950	arg1	matrix					976:981	The conventionally used carbohydrate separation matrix	928:981	The conventionally used carbohydrate separation matrix	928:981	The conventionally used carbohydrate separation matrix was applied for the in-process analysis of bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose.
33558961	0	31	theme	Rapid	0:4	arg1	electrophoresis					20:34	Rapid capillary gel electrophoresis	0:34	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.	0:126	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.
33558961	4	32	theme	mixture	783:789	arg1	analysis					769:776	the analysis	765:776	the analysis of a mixture of ten synthetic HMOs	765:811	In this work, two commercially available gel compositions were evaluated on the analysis of a mixture of ten synthetic HMOs.
33558961	3	33	theme	Capillary	476:484	arg1	electrophoresis					490:504	Capillary gel electrophoresis	476:504	Capillary gel electrophoresis	476:504	Capillary gel electrophoresis primarily separates analyte molecules based on their hydrodynamic volume to charge ratios, thus, offers excellent resolution for most of such otherwise difficult-to-separate isomers.
33558961	0	34	theme	gel	16:18	arg1	electrophoresis					20:34	Rapid capillary gel electrophoresis	0:34	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.	0:126	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.
33558961	7	35	theme	fermentation	1230:1241	arg1	approach					1243:1250	a shake flask and fermentation approach	1212:1250	approach	1243:1250	The other example showed the suitability of the method for the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production.
33558961	1	36	theme	dietary	305:311	arg1	supplements					313:323	dietary supplements	305:323	dietary supplements for all age groups	305:342	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	1	36	theme	dietary	305:311	arg1	they					233:236	they	233:236	they	233:236	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	5	37	theme	respective	827:836	arg1	matrices					849:856	The relevant respective separation matrices	814:856	The relevant respective separation matrices	814:856	The relevant respective separation matrices were then applied to selected analytical in-process control examples.
33558961	1	38	theme	age	333:335	arg1	groups					337:342	all age groups	329:342	all age groups	329:342	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	9	39	theme	manufacturing	1690:1702	arg1	control					1715:1721	manufacturing in-process control	1690:1721	manufacturing in-process control	1690:1721	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	8	40	used	utilized	1334:1341	arg2	complexation					1317:1328	borate complexation	1310:1328	borate complexation	1310:1328	In this latter instance, borate complexation was utilized to efficiently separate the 2'- and 3-fucosylated lactose positional isomers.
33558961	9	41	dep	time	1555:1558	arg1	%					1607:1607	average RSD 0.26%	1591:1607	average RSD 0.26%	1591:1607	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	9	41	dep	time	1555:1558	arg1	%					1617:1617	3.56%	1613:1617	3.56%	1613:1617	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	2	42	theme	chain	381:385	arg1	lengths					387:393	their short oligosaccharide chain lengths	353:393	their short oligosaccharide chain lengths	353:393	Despite their short oligosaccharide chain lengths, HMO analysis is challenging due to extensive positional and linkage variations.
33558961	1	43	theme	key	247:249	arg1	ingredients					251:261	key ingredients	247:261	key ingredients in baby formulas	247:278	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	1	43	theme	key	247:249	arg1	they					233:236	they	233:236	they	233:236	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	7	44	theme	shake	1214:1218	arg1	flask					1220:1224	a shake flask and fermentation approach	1212:1250	flask	1220:1224	The other example showed the suitability of the method for the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production.
33558961	2	45	theme	short	359:363	arg1	lengths					387:393	their short oligosaccharide chain lengths	353:393	their short oligosaccharide chain lengths	353:393	Despite their short oligosaccharide chain lengths, HMO analysis is challenging due to extensive positional and linkage variations.
33558961	7	46	theme	in-process	1190:1199	arg1	control					1201:1207	the in vivo in-process control	1178:1207	the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production	1178:1282	The other example showed the suitability of the method for the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production.
33558961	6	47	theme	carbohydrate	952:963	arg1	matrix					976:981	The conventionally used carbohydrate separation matrix	928:981	The conventionally used carbohydrate separation matrix	928:981	The conventionally used carbohydrate separation matrix was applied for the in-process analysis of bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose.
33558961	7	48	theme	in	1182:1183	arg1	control					1201:1207	the in vivo in-process control	1178:1207	the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production	1178:1282	The other example showed the suitability of the method for the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production.
33558961	3	49	theme	hydrodynamic	559:570	arg1	volume					572:577	their hydrodynamic volume	553:577	their hydrodynamic volume	553:577	Capillary gel electrophoresis primarily separates analyte molecules based on their hydrodynamic volume to charge ratios, thus, offers excellent resolution for most of such otherwise difficult-to-separate isomers.
33558961	5	50	theme	in-process	899:908	arg1	examples					918:925	selected analytical in-process control examples	879:925	selected analytical in-process control examples	879:925	The relevant respective separation matrices were then applied to selected analytical in-process control examples.
33558961	0	51	theme	human	48:52	arg1	oligosaccharides					59:74	human milk oligosaccharides	48:74	human milk oligosaccharides	48:74	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.
33558961	9	52	theme	excellent	1535:1543	arg1	time					1555:1558	excellent migration time	1535:1558	excellent migration time	1535:1558	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	1	53	theme	growing	210:216	arg1	interest					218:225	a recently growing interest	199:225	a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups	199:342	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	6	54	theme	bacteria-mediated	1026:1042	arg1	production					1044:1053	bacteria-mediated production	1026:1053	bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose	1026:1116	The conventionally used carbohydrate separation matrix was applied for the in-process analysis of bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose.
33558961	9	55	theme	peak	1564:1567	arg1	reproducibility					1574:1588	peak area reproducibility	1564:1588	peak area reproducibility	1564:1588	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	8	56	theme	2'-	1371:1373	arg1	isomers					1412:1418	the 2'- and 3-fucosylated lactose positional isomers	1367:1418	the 2'- and 3-fucosylated lactose positional isomers	1367:1418	In this latter instance, borate complexation was utilized to efficiently separate the 2'- and 3-fucosylated lactose positional isomers.
33558961	7	57	dep	in	1182:1183	arg1	vivo					1185:1188	vivo	1185:1188	vivo	1185:1188	The other example showed the suitability of the method for the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production.
33558961	1	58	theme	Industrial	128:137	arg1	production					139:148	Industrial production	128:148	Industrial production of human milk oligosaccharides (HMOs)	128:186	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	8	59	theme	borate	1310:1315	arg1	complexation					1317:1328	borate complexation	1310:1328	borate complexation	1310:1328	In this latter instance, borate complexation was utilized to efficiently separate the 2'- and 3-fucosylated lactose positional isomers.
33558961	8	60	theme	3-fucosylated	1379:1391	arg1	isomers					1412:1418	the 2'- and 3-fucosylated lactose positional isomers	1367:1418	the 2'- and 3-fucosylated lactose positional isomers	1367:1418	In this latter instance, borate complexation was utilized to efficiently separate the 2'- and 3-fucosylated lactose positional isomers.
33558961	7	61	theme	other	1123:1127	arg1	example					1129:1135	The other example	1119:1135	The other example	1119:1135	The other example showed the suitability of the method for the in vivo in-process control of a shake flask and fermentation approach of 2'-fucosyllactose production.
33558961	3	62	theme	such	643:646	arg1	isomers					680:686	such otherwise difficult-to-separate isomers	643:686	such otherwise difficult-to-separate isomers	643:686	Capillary gel electrophoresis primarily separates analyte molecules based on their hydrodynamic volume to charge ratios, thus, offers excellent resolution for most of such otherwise difficult-to-separate isomers.
33558961	9	63	theme	average RSD	1591:1601	arg1	%					1607:1607	average RSD 0.26%	1591:1607	average RSD 0.26%	1591:1607	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	9	64	from	importance	1662:1671	arg1	food					1676:1679	food	1676:1679	food additive manufacturing in-process control	1676:1721	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	8	65	theme	positional	1401:1410	arg1	isomers					1412:1418	the 2'- and 3-fucosylated lactose positional isomers	1367:1418	the 2'- and 3-fucosylated lactose positional isomers	1367:1418	In this latter instance, borate complexation was utilized to efficiently separate the 2'- and 3-fucosylated lactose positional isomers.
33558961	1	66	theme	milk	159:162	arg1	oligosaccharides					164:179	human milk oligosaccharides	153:179	human milk oligosaccharides (HMOs)	153:186	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	1	66	theme	milk	159:162	arg1	HMOs					182:185	HMOs	182:185	HMOs	182:185	Industrial production of human milk oligosaccharides (HMOs) represents a recently growing interest since they serve as key ingredients in baby formulas and are also utilized as dietary supplements for all age groups.
33558961	6	67	theme	lacto-N-neotetraose	1098:1116	arg1	production					1044:1053	bacteria-mediated production	1026:1053	bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose	1026:1116	The conventionally used carbohydrate separation matrix was applied for the in-process analysis of bacteria-mediated production of 3-fucosyllactose, lacto-N-tetraose, and lacto-N-neotetraose.
33558961	0	68	theme	additive	85:92	arg1	control					119:125	food additive manufacturing in-process control	80:125	food additive manufacturing in-process control	80:125	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.
33558961	4	69	theme	gel	730:732	arg1	compositions					734:745	two commercially available gel compositions	703:745	two commercially available gel compositions	703:745	In this work, two commercially available gel compositions were evaluated on the analysis of a mixture of ten synthetic HMOs.
33558961	0	70	theme	in-process	108:117	arg1	control					119:125	food additive manufacturing in-process control	80:125	food additive manufacturing in-process control	80:125	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.
33558961	2	71	dep	positional	441:450	arg1	variations					464:473	variations	464:473	variations	464:473	Despite their short oligosaccharide chain lengths, HMO analysis is challenging due to extensive positional and linkage variations.
33558961	4	72	theme	synthetic	798:806	arg1	HMOs					808:811	ten synthetic HMOs	794:811	ten synthetic HMOs	794:811	In this work, two commercially available gel compositions were evaluated on the analysis of a mixture of ten synthetic HMOs.
33558961	2	73	theme	HMO	396:398	arg1	analysis					400:407	HMO analysis	396:407	HMO analysis	396:407	Despite their short oligosaccharide chain lengths, HMO analysis is challenging due to extensive positional and linkage variations.
33558961	5	74	theme	separation	838:847	arg1	matrices					849:856	The relevant respective separation matrices	814:856	The relevant respective separation matrices	814:856	The relevant respective separation matrices were then applied to selected analytical in-process control examples.
33558961	0	75	theme	electrophoresis	20:34	arg1	analysis					36:43	Rapid capillary gel electrophoresis analysis	0:43	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.	0:126	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.
33558961	9	76	theme	high	1657:1660	arg1	importance					1662:1671	high importance	1657:1671	high importance in food additive manufacturing in-process control	1657:1721	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	3	77	theme	gel	486:488	arg1	electrophoresis					490:504	Capillary gel electrophoresis	476:504	Capillary gel electrophoresis	476:504	Capillary gel electrophoresis primarily separates analyte molecules based on their hydrodynamic volume to charge ratios, thus, offers excellent resolution for most of such otherwise difficult-to-separate isomers.
33558961	5	78	theme	selected	879:886	arg1	examples					918:925	selected analytical in-process control examples	879:925	selected analytical in-process control examples	879:925	The relevant respective separation matrices were then applied to selected analytical in-process control examples.
33558961	3	79	theme	difficult-to-separate	658:678	arg1	isomers					680:686	such otherwise difficult-to-separate isomers	643:686	such otherwise difficult-to-separate isomers	643:686	Capillary gel electrophoresis primarily separates analyte molecules based on their hydrodynamic volume to charge ratios, thus, offers excellent resolution for most of such otherwise difficult-to-separate isomers.
33558961	5	80	theme	relevant	818:825	arg1	matrices					849:856	The relevant respective separation matrices	814:856	The relevant respective separation matrices	814:856	The relevant respective separation matrices were then applied to selected analytical in-process control examples.
33558961	9	81	theme	HMOs	1459:1462	arg1	analysis					1443:1450	the analysis	1439:1450	the analysis of the HMOs of interest	1439:1474	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	9	82	theme	additive	1681:1688	arg1	food					1676:1679	food	1676:1679	food additive manufacturing in-process control	1676:1721	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	3	83	theme	analyte	526:532	arg1	molecules					534:542	analyte molecules	526:542	analyte molecules based on their hydrodynamic volume	526:577	Capillary gel electrophoresis primarily separates analyte molecules based on their hydrodynamic volume to charge ratios, thus, offers excellent resolution for most of such otherwise difficult-to-separate isomers.
33558961	9	84	theme	interest	1467:1474	arg1	HMOs					1459:1462	the HMOs	1455:1462	the HMOs of interest	1455:1474	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	9	85	theme	in-process	1704:1713	arg1	control					1715:1721	manufacturing in-process control	1690:1721	manufacturing in-process control	1690:1721	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	2	86	theme	oligosaccharide	365:379	arg1	lengths					387:393	their short oligosaccharide chain lengths	353:393	their short oligosaccharide chain lengths	353:393	Despite their short oligosaccharide chain lengths, HMO analysis is challenging due to extensive positional and linkage variations.
33558961	9	87	theme	area	1569:1572	arg1	reproducibility					1574:1588	peak area reproducibility	1564:1588	peak area reproducibility	1564:1588	In all instances, the analysis of the HMOs of interest required only a couple of minutes with high resolution and excellent migration time and peak area reproducibility (average RSD 0.26% and 3.56%, respectively), features representing high importance in food additive manufacturing in-process control.
33558961	0	88	theme	capillary	6:14	arg1	electrophoresis					20:34	Rapid capillary gel electrophoresis	0:34	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.	0:126	Rapid capillary gel electrophoresis analysis of human milk oligosaccharides for food additive manufacturing in-process control.
34119541	0	0	theme	substrate	118:126	arg1	anticorrosion					63:75	self-strengthening anticorrosion	44:75	self-strengthening anticorrosion	44:75	Chitosan-sodium alginate-based coatings for self-strengthening anticorrosion and antibacterial protection of titanium substrate in artificial saliva.
34119541	0	0	theme	substrate	118:126	arg1	protection					95:104	antibacterial protection	81:104	antibacterial protection	81:104	Chitosan-sodium alginate-based coatings for self-strengthening anticorrosion and antibacterial protection of titanium substrate in artificial saliva.
34119541	1	1	theme	Ti	337:338	arg1	substrate					340:348	polydopamine (PDA) coated Ti substrate	311:348	polydopamine (PDA) coated Ti substrate	311:348	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	0	2	theme	titanium	109:116	arg1	substrate					118:126	titanium substrate	109:126	titanium substrate	109:126	Chitosan-sodium alginate-based coatings for self-strengthening anticorrosion and antibacterial protection of titanium substrate in artificial saliva.
34119541	1	3	theme	substrate	340:348	arg1	surface					300:306	the surface	296:306	the surface of polydopamine (PDA) coated Ti substrate	296:348	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	2	4	theme	Ag	481:482	arg1	NPs					484:486	Ag NPs	481:486	Ag NPs	481:486	The PDA coating exhibited an excellent bond with Ti substrate, and also can uniformly deposit Ag NPs via a mild method without introducing any exogenous reductant.
34119541	1	5	theme	Ag	206:207	arg1	nanoparticles					191:203	silver nanoparticles	184:203	silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes	184:275	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	1	5	theme	Ag	206:207	arg1	NPs					209:211	Ag NPs	206:211	Ag NPs	206:211	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	7	6	from	zone	1422:1425	arg1	mutans					1433:1438	S. mutans	1430:1438	S. mutans	1430:1438	Furthermore, the ŋ remained up to 96.8% after immersion of 30 days, and then the coating also displayed a distinct inhibition zone on S. mutans.
34119541	0	7	theme	artificial	131:140	arg1	saliva					142:147	artificial saliva	131:147	artificial saliva	131:147	Chitosan-sodium alginate-based coatings for self-strengthening anticorrosion and antibacterial protection of titanium substrate in artificial saliva.
34119541	8	8	theme	excellent	1487:1495	arg1	performance					1511:1521	an excellent anticorrosion performance	1484:1521	an excellent anticorrosion performance	1484:1521	These results prove this coating possesses an excellent anticorrosion performance and antibacterial property.
34119541	7	9	dep	96.8	1330:1333	arg1	to					1327:1328	to	1327:1328	to	1327:1328	Furthermore, the ŋ remained up to 96.8% after immersion of 30 days, and then the coating also displayed a distinct inhibition zone on S. mutans.
34119541	4	10	theme	corrosive	741:749	arg1	medium					751:756	a corrosive medium	739:756	a corrosive medium	739:756	The SA was introduced to enhance the anticorrosion performance by forming calcium alginate (CA) in a corrosive medium.
34119541	6	11	theme	film	1181:1184	arg1	compositions					1151:1162	the compositions	1147:1162	the compositions of the outermost film	1147:1184	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	6	12	theme	continuous	1012:1021	arg1	increase					1023:1030	a continuous increase	1010:1030	a continuous increase	1010:1030	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	2	13	with	bond	426:429	arg1	substrate					439:447	Ti substrate	436:447	Ti substrate	436:447	The PDA coating exhibited an excellent bond with Ti substrate, and also can uniformly deposit Ag NPs via a mild method without introducing any exogenous reductant.
34119541	6	14	theme	EDS	1282:1284	arg1	analysis					1286:1293	EDS analysis	1282:1293	EDS analysis	1282:1293	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	8	15	contain	possesses	1474:1482	arg2	property					1541:1548	antibacterial property	1527:1548	antibacterial property	1527:1548	These results prove this coating possesses an excellent anticorrosion performance and antibacterial property.
34119541	8	15	contain	possesses	1474:1482	arg2	performance					1511:1521	an excellent anticorrosion performance	1484:1521	an excellent anticorrosion performance	1484:1521	These results prove this coating possesses an excellent anticorrosion performance and antibacterial property.
34119541	8	15	contain	possesses	1474:1482	arg1	coating					1466:1472	this coating	1461:1472	this coating	1461:1472	These results prove this coating possesses an excellent anticorrosion performance and antibacterial property.
34119541	2	16	theme	mild	494:497	arg1	method					499:504	a mild method	492:504	a mild method	492:504	The PDA coating exhibited an excellent bond with Ti substrate, and also can uniformly deposit Ag NPs via a mild method without introducing any exogenous reductant.
34119541	1	17	theme	layer-by-layer	355:368	arg1	method					379:384	a layer-by-layer assembly method	353:384	a layer-by-layer assembly method	353:384	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	1	18	with	coating	171:177	arg1	nanoparticles					191:203	silver nanoparticles	184:203	silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes	184:275	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	1	18	with	coating	171:177	arg1	NPs					209:211	Ag NPs	206:211	Ag NPs	206:211	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	7	19	theme	distinct	1402:1409	arg1	zone					1422:1425	a distinct inhibition zone	1400:1425	a distinct inhibition zone on S. mutans	1400:1438	Furthermore, the ŋ remained up to 96.8% after immersion of 30 days, and then the coating also displayed a distinct inhibition zone on S. mutans.
34119541	6	20	theme	self-strengthening	1112:1129	arg1	capability					1131:1140	a remarkable self-strengthening capability	1099:1140	a remarkable self-strengthening capability	1099:1140	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	0	21	from	anticorrosion	63:75	arg1	saliva					142:147	artificial saliva	131:147	artificial saliva	131:147	Chitosan-sodium alginate-based coatings for self-strengthening anticorrosion and antibacterial protection of titanium substrate in artificial saliva.
34119541	7	22	theme	inhibition	1411:1420	arg1	zone					1422:1425	a distinct inhibition zone	1400:1425	a distinct inhibition zone on S. mutans	1400:1438	Furthermore, the ŋ remained up to 96.8% after immersion of 30 days, and then the coating also displayed a distinct inhibition zone on S. mutans.
34119541	2	23	theme	PDA	391:393	arg1	coating					395:401	The PDA coating	387:401	The PDA coating	387:401	The PDA coating exhibited an excellent bond with Ti substrate, and also can uniformly deposit Ag NPs via a mild method without introducing any exogenous reductant.
34119541	0	24	theme	alginate-based	16:29	arg1	coatings					31:38	Chitosan-sodium alginate-based coatings	0:38	Chitosan-sodium alginate-based coatings for self-strengthening anticorrosion and antibacterial protection of titanium substrate in artificial saliva.	0:148	Chitosan-sodium alginate-based coatings for self-strengthening anticorrosion and antibacterial protection of titanium substrate in artificial saliva.
34119541	8	25	theme	antibacterial	1527:1539	arg1	property					1541:1548	antibacterial property	1527:1548	antibacterial property	1527:1548	These results prove this coating possesses an excellent anticorrosion performance and antibacterial property.
34119541	3	26	theme	CHI	555:557	arg1	coating					559:565	The CHI coating	551:565	The CHI coating	551:565	The CHI coating was assembled through a spin-coating method for controlling Ag+ release.
34119541	5	27	theme	fluorine-containing	878:896	arg1	saliva					909:914	fluorine-containing artificial saliva	878:914	fluorine-containing artificial saliva	878:914	The corrosion protection was investigated with electrochemical impedance spectroscopy and polarization curves tests in fluorine-containing artificial saliva.
34119541	0	28	theme	Chitosan-sodium	0:14	arg1	coatings					31:38	Chitosan-sodium alginate-based coatings	0:38	Chitosan-sodium alginate-based coatings for self-strengthening anticorrosion and antibacterial protection of titanium substrate in artificial saliva.	0:148	Chitosan-sodium alginate-based coatings for self-strengthening anticorrosion and antibacterial protection of titanium substrate in artificial saliva.
34119541	6	29	with	CA	1205:1206	arg1	cations					1222:1228	the Ca2+ cations	1213:1228	the Ca2+ cations of the corrosive medium	1213:1252	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	5	30	theme	artificial	898:907	arg1	saliva					909:914	fluorine-containing artificial saliva	878:914	fluorine-containing artificial saliva	878:914	The corrosion protection was investigated with electrochemical impedance spectroscopy and polarization curves tests in fluorine-containing artificial saliva.
34119541	2	31	theme	Ti	436:437	arg1	substrate					439:447	Ti substrate	436:447	Ti substrate	436:447	The PDA coating exhibited an excellent bond with Ti substrate, and also can uniformly deposit Ag NPs via a mild method without introducing any exogenous reductant.
34119541	5	32	dep	spectroscopy	832:843	arg1	tests					869:873	tests	869:873	tests	869:873	The corrosion protection was investigated with electrochemical impedance spectroscopy and polarization curves tests in fluorine-containing artificial saliva.
34119541	5	33	theme	impedance	822:830	arg1	spectroscopy					832:843	electrochemical impedance spectroscopy	806:843	electrochemical impedance spectroscopy	806:843	The corrosion protection was investigated with electrochemical impedance spectroscopy and polarization curves tests in fluorine-containing artificial saliva.
34119541	2	34	theme	exogenous	530:538	arg1	reductant					540:548	any exogenous reductant	526:548	any exogenous reductant	526:548	The PDA coating exhibited an excellent bond with Ti substrate, and also can uniformly deposit Ag NPs via a mild method without introducing any exogenous reductant.
34119541	4	35	theme	anticorrosion	677:689	arg1	performance					691:701	the anticorrosion performance	673:701	the anticorrosion performance	673:701	The SA was introduced to enhance the anticorrosion performance by forming calcium alginate (CA) in a corrosive medium.
34119541	6	36	theme	charge-transfer	939:953	arg1	resistance					955:964	the charge-transfer resistance	935:964	the charge-transfer resistance	935:964	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	2	37	theme	excellent	416:424	arg1	bond					426:429	an excellent bond	413:429	an excellent bond with Ti substrate	413:447	The PDA coating exhibited an excellent bond with Ti substrate, and also can uniformly deposit Ag NPs via a mild method without introducing any exogenous reductant.
34119541	5	38	theme	polarization	849:860	arg1	curves					862:867	polarization curves	849:867	polarization curves	849:867	The corrosion protection was investigated with electrochemical impedance spectroscopy and polarization curves tests in fluorine-containing artificial saliva.
34119541	0	39	theme	self-strengthening	44:61	arg1	anticorrosion					63:75	self-strengthening anticorrosion	44:75	self-strengthening anticorrosion	44:75	Chitosan-sodium alginate-based coatings for self-strengthening anticorrosion and antibacterial protection of titanium substrate in artificial saliva.
34119541	5	40	theme	corrosion	763:771	arg1	protection					773:782	The corrosion protection	759:782	The corrosion protection	759:782	The corrosion protection was investigated with electrochemical impedance spectroscopy and polarization curves tests in fluorine-containing artificial saliva.
34119541	3	41	theme	Ag+	627:629	arg1	release					631:637	Ag+ release	627:637	Ag+ release	627:637	The CHI coating was assembled through a spin-coating method for controlling Ag+ release.
34119541	1	42	dep	chitosan	220:227	arg1	polyelectrolytes					260:275	polyelectrolytes	260:275	polyelectrolytes	260:275	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	5	43	theme	electrochemical	806:820	arg1	spectroscopy					832:843	electrochemical impedance spectroscopy	806:843	electrochemical impedance spectroscopy	806:843	The corrosion protection was investigated with electrochemical impedance spectroscopy and polarization curves tests in fluorine-containing artificial saliva.
34119541	0	44	theme	antibacterial	81:93	arg1	protection					95:104	antibacterial protection	81:104	antibacterial protection	81:104	Chitosan-sodium alginate-based coatings for self-strengthening anticorrosion and antibacterial protection of titanium substrate in artificial saliva.
34119541	6	45	theme	protection	974:983	arg1	ŋ					997:997	ŋ	997:997	ŋ	997:997	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	6	45	theme	protection	974:983	arg1	efficiency					985:994	the protection efficiency	970:994	the protection efficiency (ŋ)	970:998	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	0	46	from	protection	95:104	arg1	saliva					142:147	artificial saliva	131:147	artificial saliva	131:147	Chitosan-sodium alginate-based coatings for self-strengthening anticorrosion and antibacterial protection of titanium substrate in artificial saliva.
34119541	6	47	theme	medium	1247:1252	arg1	cations					1222:1228	the Ca2+ cations	1213:1228	the Ca2+ cations of the corrosive medium	1213:1252	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	1	48	theme	assembly	370:377	arg1	method					379:384	a layer-by-layer assembly method	353:384	a layer-by-layer assembly method	353:384	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	6	49	theme	outermost	1171:1179	arg1	film					1181:1184	the outermost film	1167:1184	the outermost film	1167:1184	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	6	50	contain	possessed	1089:1097	arg2	capability					1131:1140	a remarkable self-strengthening capability	1099:1140	a remarkable self-strengthening capability	1099:1140	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	6	50	contain	possessed	1089:1097	arg1	coating					1081:1087	this coating	1076:1087	this coating	1076:1087	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	6	51	theme	corrosive	1237:1245	arg1	medium					1247:1252	the corrosive medium	1233:1252	the corrosive medium	1233:1252	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	1	52	theme	self-strengthening	152:169	arg1	coating					171:177	A self-strengthening coating	150:177	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes	150:275	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	1	53	theme	sodium	239:244	arg1	SA					256:257	SA	256:257	SA	256:257	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	1	53	theme	sodium	239:244	arg1	alginate					246:253	sodium alginate	239:253	sodium alginate (SA)	239:258	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	7	54	theme	30 days	1355:1361	arg1	immersion					1342:1350	immersion	1342:1350	immersion of 30 days	1342:1361	Furthermore, the ŋ remained up to 96.8% after immersion of 30 days, and then the coating also displayed a distinct inhibition zone on S. mutans.
34119541	4	55	theme	calcium	714:720	arg1	CA					732:733	CA	732:733	CA	732:733	The SA was introduced to enhance the anticorrosion performance by forming calcium alginate (CA) in a corrosive medium.
34119541	4	55	theme	calcium	714:720	arg1	alginate					722:729	calcium alginate	714:729	calcium alginate (CA)	714:734	The SA was introduced to enhance the anticorrosion performance by forming calcium alginate (CA) in a corrosive medium.
34119541	8	56	theme	anticorrosion	1497:1509	arg1	performance					1511:1521	an excellent anticorrosion performance	1484:1521	an excellent anticorrosion performance	1484:1521	These results prove this coating possesses an excellent anticorrosion performance and antibacterial property.
34119541	3	57	theme	spin-coating	591:602	arg1	method					604:609	a spin-coating method	589:609	a spin-coating method for controlling Ag+ release	589:637	The CHI coating was assembled through a spin-coating method for controlling Ag+ release.
34119541	1	58	theme	silver	184:189	arg1	nanoparticles					191:203	silver nanoparticles	184:203	silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes	184:275	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	1	58	theme	silver	184:189	arg1	NPs					209:211	Ag NPs	206:211	Ag NPs	206:211	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	6	59	theme	remarkable	1101:1110	arg1	capability					1131:1140	a remarkable self-strengthening capability	1099:1140	a remarkable self-strengthening capability	1099:1140	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	6	60	theme	immersion	1041:1049	arg1	time					1051:1054	the immersion time	1037:1054	the immersion time	1037:1054	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
34119541	1	61	theme	coated	330:335	arg1	substrate					340:348	polydopamine (PDA) coated Ti substrate	311:348	polydopamine (PDA) coated Ti substrate	311:348	A self-strengthening coating with silver nanoparticles (Ag NPs) doped chitosan (CHI) and sodium alginate (SA) polyelectrolytes was constructed on the surface of polydopamine (PDA) coated Ti substrate by a layer-by-layer assembly method.
34119541	6	62	theme	Ca2+	1217:1220	arg1	cations					1222:1228	the Ca2+ cations	1213:1228	the Ca2+ cations of the corrosive medium	1213:1252	During immersion, the charge-transfer resistance and the protection efficiency (ŋ) presented a continuous increase with the immersion time, demonstrating that this coating possessed a remarkable self-strengthening capability, and the compositions of the outermost film changed from SA to CA with the Ca2+ cations of the corrosive medium as a crosslinker by SEM and EDS analysis.
33200759	2	0	theme	endothelial	464:474	arg1	factor					483:488	vascular endothelial growth factor	455:488	vascular endothelial growth factor	455:488	In our research, a functional composite scaffold constituted by collagen, heparin and vascular endothelial growth factor was used to stimulate angiogenesis and improve nerve-tissue regeneration in a rat model of TBI.
33200759	6	1	theme	inflammatory	1063:1074	arg1	reactions					1076:1084	inflammatory reactions	1063:1084	inflammatory reactions	1063:1084	Furthermore, brain edema and inflammatory reactions were significantly alleviated.
33200759	1	2	theme	scaffold	243:250	arg1	effects					213:219	the therapy effects	201:219	the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI)	201:366	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	2	3	theme	vascular	455:462	arg1	factor					483:488	vascular endothelial growth factor	455:488	vascular endothelial growth factor	455:488	In our research, a functional composite scaffold constituted by collagen, heparin and vascular endothelial growth factor was used to stimulate angiogenesis and improve nerve-tissue regeneration in a rat model of TBI.
33200759	2	4	theme	TBI	581:583	arg1	model					572:576	a rat model	566:576	a rat model of TBI	566:583	In our research, a functional composite scaffold constituted by collagen, heparin and vascular endothelial growth factor was used to stimulate angiogenesis and improve nerve-tissue regeneration in a rat model of TBI.
33200759	8	5	theme	potential	1476:1484	arg1	strategy					1486:1493	a potential strategy	1474:1493	a potential strategy for treating TBI	1474:1510	In conclusion, our data revealed that the collagen/heparin scaffold combined with VEGF could create excellent microenvironment stimuli for damaged nerve-tissue regeneration, providing a potential strategy for treating TBI.
33200759	4	6	from	site	923:926	arg1	model					943:947	the rat TBI model	931:947	the rat TBI model	931:947	Motor and cognitive functions such as motor evoked potential, Morris water maze test and modified neurological severity score were evidently improved after the scaffold was grafted onto the injury site in the rat TBI model.
33200759	0	7	theme	function	111:118	arg1	repair					88:93	the repair	84:93	the repair of neurological function in rats with traumatic brain injury	84:154	Collagen/heparin scaffold combined with vascular endothelial growth factor promotes the repair of neurological function in rats with traumatic brain injury.
33200759	1	8	theme	traumatic	339:347	arg1	injury					355:360	traumatic brain injury	339:360	traumatic brain injury (TBI)	339:366	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	1	8	theme	traumatic	339:347	arg1	TBI					363:365	TBI	363:365	TBI	363:365	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	8	9	theme	collagen/heparin	1332:1347	arg1	scaffold					1349:1356	the collagen/heparin scaffold	1328:1356	the collagen/heparin scaffold combined with VEGF	1328:1375	In conclusion, our data revealed that the collagen/heparin scaffold combined with VEGF could create excellent microenvironment stimuli for damaged nerve-tissue regeneration, providing a potential strategy for treating TBI.
33200759	7	10	with	fibers	1181:1186	arg1	endothelium					1244:1254	intact endothelium	1237:1254	intact endothelium	1237:1254	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	0	11	theme	neurological	98:109	arg1	function					111:118	neurological function	98:118	neurological function	98:118	Collagen/heparin scaffold combined with vascular endothelial growth factor promotes the repair of neurological function in rats with traumatic brain injury.
33200759	1	12	theme	brain	349:353	arg1	injury					355:360	traumatic brain injury	339:360	traumatic brain injury (TBI)	339:366	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	1	12	theme	brain	349:353	arg1	TBI					363:365	TBI	363:365	TBI	363:365	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	7	13	with	neurons	1130:1136	arg1	structures					1163:1172	associated synaptic structures	1143:1172	associated synaptic structures	1143:1172	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	7	13	with	neurons	1130:1136	arg1	fibers					1181:1186	nerve fibers	1175:1186	nerve fibers	1175:1186	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	7	13	with	neurons	1130:1136	arg1	sheaths					1196:1202	myelin sheaths	1189:1202	myelin sheaths	1189:1202	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	7	13	with	neurons	1130:1136	arg1	angiogenesis					1219:1230	functional angiogenesis	1208:1230	functional angiogenesis with intact endothelium at the injury site	1208:1273	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	7	14	theme	intact	1237:1242	arg1	endothelium					1244:1254	intact endothelium	1237:1254	intact endothelium	1237:1254	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	4	15	theme	TBI	939:941	arg1	model					943:947	the rat TBI model	931:947	the rat TBI model	931:947	Motor and cognitive functions such as motor evoked potential, Morris water maze test and modified neurological severity score were evidently improved after the scaffold was grafted onto the injury site in the rat TBI model.
33200759	3	16	theme	VEGF	720:723	arg1	rate					712:715	the release rate	700:715	the release rate of VEGF	700:723	The composite scaffold possessed excellent mechanical properties and good porosity, and could effectively control the release rate of VEGF.
33200759	4	17	theme	neurological	824:835	arg1	score					846:850	modified neurological severity score	815:850	modified neurological severity score	815:850	Motor and cognitive functions such as motor evoked potential, Morris water maze test and modified neurological severity score were evidently improved after the scaffold was grafted onto the injury site in the rat TBI model.
33200759	4	18	theme	rat	935:937	arg1	model					943:947	the rat TBI model	931:947	the rat TBI model	931:947	Motor and cognitive functions such as motor evoked potential, Morris water maze test and modified neurological severity score were evidently improved after the scaffold was grafted onto the injury site in the rat TBI model.
33200759	3	19	theme	release	704:710	arg1	rate					712:715	the release rate	700:715	the release rate of VEGF	700:723	The composite scaffold possessed excellent mechanical properties and good porosity, and could effectively control the release rate of VEGF.
33200759	4	20	theme	modified	815:822	arg1	score					846:850	modified neurological severity score	815:850	modified neurological severity score	815:850	Motor and cognitive functions such as motor evoked potential, Morris water maze test and modified neurological severity score were evidently improved after the scaffold was grafted onto the injury site in the rat TBI model.
33200759	0	21	with	rats	123:126	arg1	injury					149:154	traumatic brain injury	133:154	traumatic brain injury	133:154	Collagen/heparin scaffold combined with vascular endothelial growth factor promotes the repair of neurological function in rats with traumatic brain injury.
33200759	7	22	theme	nerve	1175:1179	arg1	fibers					1181:1186	nerve fibers	1175:1186	nerve fibers	1175:1186	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	8	23	theme	microenvironment	1400:1415	arg1	stimuli					1417:1423	excellent microenvironment stimuli	1390:1423	excellent microenvironment stimuli for damaged nerve-tissue regeneration	1390:1461	In conclusion, our data revealed that the collagen/heparin scaffold combined with VEGF could create excellent microenvironment stimuli for damaged nerve-tissue regeneration, providing a potential strategy for treating TBI.
33200759	1	24	theme	study	179:183	arg1	objective					161:169	The objective	157:169	The objective of this study	157:183	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	5	25	theme	nerve	1000:1004	arg1	tissue					1006:1011	damaged nerve tissue	992:1011	damaged nerve tissue	992:1011	There was clearly improved restoration of damaged nerve tissue at the injured site.
33200759	7	26	theme	functional	1208:1217	arg1	angiogenesis					1219:1230	functional angiogenesis	1208:1230	functional angiogenesis with intact endothelium at the injury site	1208:1273	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	8	27	theme	excellent	1390:1398	arg1	stimuli					1417:1423	excellent microenvironment stimuli	1390:1423	excellent microenvironment stimuli for damaged nerve-tissue regeneration	1390:1461	In conclusion, our data revealed that the collagen/heparin scaffold combined with VEGF could create excellent microenvironment stimuli for damaged nerve-tissue regeneration, providing a potential strategy for treating TBI.
33200759	7	28	from	site	1270:1273	arg1	structures					1163:1172	associated synaptic structures	1143:1172	associated synaptic structures	1143:1172	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	7	28	from	site	1270:1273	arg1	fibers					1181:1186	nerve fibers	1175:1186	nerve fibers	1175:1186	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	7	28	from	site	1270:1273	arg1	sheaths					1196:1202	myelin sheaths	1189:1202	myelin sheaths	1189:1202	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	7	28	from	site	1270:1273	arg1	angiogenesis					1219:1230	functional angiogenesis	1208:1230	functional angiogenesis with intact endothelium at the injury site	1208:1273	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	0	29	theme	Collagen/heparin	0:15	arg1	scaffold					17:24	Collagen/heparin scaffold	0:24	Collagen/heparin scaffold combined with vascular endothelial growth factor	0:73	Collagen/heparin scaffold combined with vascular endothelial growth factor promotes the repair of neurological function in rats with traumatic brain injury.
33200759	7	30	theme	associated	1143:1152	arg1	structures					1163:1172	associated synaptic structures	1143:1172	associated synaptic structures	1143:1172	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	4	31	theme	severity	837:844	arg1	score					846:850	modified neurological severity score	815:850	modified neurological severity score	815:850	Motor and cognitive functions such as motor evoked potential, Morris water maze test and modified neurological severity score were evidently improved after the scaffold was grafted onto the injury site in the rat TBI model.
33200759	7	32	with	structures	1163:1172	arg1	endothelium					1244:1254	intact endothelium	1237:1254	intact endothelium	1237:1254	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	2	33	used	used	494:497	arg2	scaffold					409:416	a functional composite scaffold	386:416	a functional composite scaffold constituted by collagen, heparin and vascular endothelial growth factor	386:488	In our research, a functional composite scaffold constituted by collagen, heparin and vascular endothelial growth factor was used to stimulate angiogenesis and improve nerve-tissue regeneration in a rat model of TBI.
33200759	7	34	theme	synaptic	1154:1161	arg1	structures					1163:1172	associated synaptic structures	1143:1172	associated synaptic structures	1143:1172	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	4	35	theme	Morris	788:793	arg1	test					806:809	Morris water maze test	788:809	Morris water maze test	788:809	Motor and cognitive functions such as motor evoked potential, Morris water maze test and modified neurological severity score were evidently improved after the scaffold was grafted onto the injury site in the rat TBI model.
33200759	0	36	theme	traumatic	133:141	arg1	injury					149:154	traumatic brain injury	133:154	traumatic brain injury	133:154	Collagen/heparin scaffold combined with vascular endothelial growth factor promotes the repair of neurological function in rats with traumatic brain injury.
33200759	4	37	theme	cognitive	736:744	arg1	functions					746:754	cognitive functions	736:754	cognitive functions such as motor	736:768	Motor and cognitive functions such as motor evoked potential, Morris water maze test and modified neurological severity score were evidently improved after the scaffold was grafted onto the injury site in the rat TBI model.
33200759	4	37	theme	cognitive	736:744	arg1	motor					764:768	motor	764:768	motor	764:768	Motor and cognitive functions such as motor evoked potential, Morris water maze test and modified neurological severity score were evidently improved after the scaffold was grafted onto the injury site in the rat TBI model.
33200759	5	38	theme	damaged	992:998	arg1	tissue					1006:1011	damaged nerve tissue	992:1011	damaged nerve tissue	992:1011	There was clearly improved restoration of damaged nerve tissue at the injured site.
33200759	2	39	theme	functional	388:397	arg1	scaffold					409:416	a functional composite scaffold	386:416	a functional composite scaffold constituted by collagen, heparin and vascular endothelial growth factor	386:488	In our research, a functional composite scaffold constituted by collagen, heparin and vascular endothelial growth factor was used to stimulate angiogenesis and improve nerve-tissue regeneration in a rat model of TBI.
33200759	2	40	theme	composite	399:407	arg1	scaffold					409:416	a functional composite scaffold	386:416	a functional composite scaffold constituted by collagen, heparin and vascular endothelial growth factor	386:488	In our research, a functional composite scaffold constituted by collagen, heparin and vascular endothelial growth factor was used to stimulate angiogenesis and improve nerve-tissue regeneration in a rat model of TBI.
33200759	1	41	theme	vascular	285:292	arg1	factor					313:318	vascular endothelial growth factor	285:318	vascular endothelial growth factor (VEGF)	285:325	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	1	41	theme	vascular	285:292	arg1	VEGF					321:324	VEGF	321:324	VEGF	321:324	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	4	42	theme	injury	916:921	arg1	site					923:926	the injury site	912:926	the injury site in the rat TBI model	912:947	Motor and cognitive functions such as motor evoked potential, Morris water maze test and modified neurological severity score were evidently improved after the scaffold was grafted onto the injury site in the rat TBI model.
33200759	0	43	theme	endothelial	49:59	arg1	factor					68:73	vascular endothelial growth factor	40:73	vascular endothelial growth factor	40:73	Collagen/heparin scaffold combined with vascular endothelial growth factor promotes the repair of neurological function in rats with traumatic brain injury.
33200759	1	44	theme	endothelial	294:304	arg1	factor					313:318	vascular endothelial growth factor	285:318	vascular endothelial growth factor (VEGF)	285:325	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	1	44	theme	endothelial	294:304	arg1	VEGF					321:324	VEGF	321:324	VEGF	321:324	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	0	45	from	repair	88:93	arg1	rats					123:126	rats	123:126	rats with traumatic brain injury	123:154	Collagen/heparin scaffold combined with vascular endothelial growth factor promotes the repair of neurological function in rats with traumatic brain injury.
33200759	4	46	theme	maze	801:804	arg1	test					806:809	Morris water maze test	788:809	Morris water maze test	788:809	Motor and cognitive functions such as motor evoked potential, Morris water maze test and modified neurological severity score were evidently improved after the scaffold was grafted onto the injury site in the rat TBI model.
33200759	1	47	theme	therapy	205:211	arg1	effects					213:219	the therapy effects	201:219	the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI)	201:366	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	0	48	theme	vascular	40:47	arg1	factor					68:73	vascular endothelial growth factor	40:73	vascular endothelial growth factor	40:73	Collagen/heparin scaffold combined with vascular endothelial growth factor promotes the repair of neurological function in rats with traumatic brain injury.
33200759	1	49	theme	growth	306:311	arg1	factor					313:318	vascular endothelial growth factor	285:318	vascular endothelial growth factor (VEGF)	285:325	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	1	49	theme	growth	306:311	arg1	VEGF					321:324	VEGF	321:324	VEGF	321:324	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	0	50	theme	brain	143:147	arg1	injury					149:154	traumatic brain injury	133:154	traumatic brain injury	133:154	Collagen/heparin scaffold combined with vascular endothelial growth factor promotes the repair of neurological function in rats with traumatic brain injury.
33200759	3	51	theme	excellent	619:627	arg1	properties					640:649	excellent mechanical properties	619:649	excellent mechanical properties	619:649	The composite scaffold possessed excellent mechanical properties and good porosity, and could effectively control the release rate of VEGF.
33200759	3	52	contain	possessed	609:617	arg2	porosity					660:667	good porosity	655:667	good porosity	655:667	The composite scaffold possessed excellent mechanical properties and good porosity, and could effectively control the release rate of VEGF.
33200759	3	52	contain	possessed	609:617	arg1	scaffold					600:607	The composite scaffold	586:607	The composite scaffold	586:607	The composite scaffold possessed excellent mechanical properties and good porosity, and could effectively control the release rate of VEGF.
33200759	3	52	contain	possessed	609:617	arg2	properties					640:649	excellent mechanical properties	619:649	excellent mechanical properties	619:649	The composite scaffold possessed excellent mechanical properties and good porosity, and could effectively control the release rate of VEGF.
33200759	7	53	theme	formed	1123:1128	arg1	neurons					1130:1136	Newly formed neurons	1117:1136	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site	1117:1273	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	7	54	theme	myelin	1189:1194	arg1	sheaths					1196:1202	myelin sheaths	1189:1202	myelin sheaths	1189:1202	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	2	55	theme	rat	568:570	arg1	model					572:576	a rat model	566:576	a rat model of TBI	566:583	In our research, a functional composite scaffold constituted by collagen, heparin and vascular endothelial growth factor was used to stimulate angiogenesis and improve nerve-tissue regeneration in a rat model of TBI.
33200759	3	56	theme	mechanical	629:638	arg1	properties					640:649	excellent mechanical properties	619:649	excellent mechanical properties	619:649	The composite scaffold possessed excellent mechanical properties and good porosity, and could effectively control the release rate of VEGF.
33200759	5	57	theme	tissue	1006:1011	arg1	restoration					977:987	restoration	977:987	restoration of damaged nerve tissue	977:1011	There was clearly improved restoration of damaged nerve tissue at the injured site.
33200759	0	58	theme	growth	61:66	arg1	factor					68:73	vascular endothelial growth factor	40:73	vascular endothelial growth factor	40:73	Collagen/heparin scaffold combined with vascular endothelial growth factor promotes the repair of neurological function in rats with traumatic brain injury.
33200759	7	59	with	angiogenesis	1219:1230	arg1	endothelium					1244:1254	intact endothelium	1237:1254	intact endothelium	1237:1254	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	2	60	theme	nerve-tissue	537:548	arg1	regeneration					550:561	nerve-tissue regeneration	537:561	nerve-tissue regeneration	537:561	In our research, a functional composite scaffold constituted by collagen, heparin and vascular endothelial growth factor was used to stimulate angiogenesis and improve nerve-tissue regeneration in a rat model of TBI.
33200759	7	61	with	sheaths	1196:1202	arg1	endothelium					1244:1254	intact endothelium	1237:1254	intact endothelium	1237:1254	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	5	62	theme	injured	1020:1026	arg1	site					1028:1031	the injured site	1016:1031	the injured site	1016:1031	There was clearly improved restoration of damaged nerve tissue at the injured site.
33200759	8	63	theme	nerve-tissue	1437:1448	arg1	regeneration					1450:1461	damaged nerve-tissue regeneration	1429:1461	damaged nerve-tissue regeneration	1429:1461	In conclusion, our data revealed that the collagen/heparin scaffold combined with VEGF could create excellent microenvironment stimuli for damaged nerve-tissue regeneration, providing a potential strategy for treating TBI.
33200759	4	64	theme	water	795:799	arg1	test					806:809	Morris water maze test	788:809	Morris water maze test	788:809	Motor and cognitive functions such as motor evoked potential, Morris water maze test and modified neurological severity score were evidently improved after the scaffold was grafted onto the injury site in the rat TBI model.
33200759	7	65	theme	injury	1263:1268	arg1	site					1270:1273	the injury site	1259:1273	the injury site	1259:1273	Newly formed neurons with associated synaptic structures, nerve fibers, myelin sheaths and functional angiogenesis with intact endothelium at the injury site were observed.
33200759	3	66	theme	good	655:658	arg1	porosity					660:667	good porosity	655:667	good porosity	655:667	The composite scaffold possessed excellent mechanical properties and good porosity, and could effectively control the release rate of VEGF.
33200759	8	67	theme	damaged	1429:1435	arg1	regeneration					1450:1461	damaged nerve-tissue regeneration	1429:1461	damaged nerve-tissue regeneration	1429:1461	In conclusion, our data revealed that the collagen/heparin scaffold combined with VEGF could create excellent microenvironment stimuli for damaged nerve-tissue regeneration, providing a potential strategy for treating TBI.
33200759	1	68	contain	containing	252:261	arg2	VEGF					321:324	VEGF	321:324	VEGF	321:324	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	1	68	contain	containing	252:261	arg2	collagen					272:279	collagen	272:279	collagen	272:279	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	1	68	contain	containing	252:261	arg2	factor					313:318	vascular endothelial growth factor	285:318	vascular endothelial growth factor (VEGF)	285:325	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	1	68	contain	containing	252:261	arg2	heparin					263:269	heparin	263:269	heparin	263:269	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	1	68	contain	containing	252:261	arg1	scaffold					243:250	a novel biological scaffold	224:250	a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI)	224:366	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	6	69	theme	brain	1047:1051	arg1	edema					1053:1057	brain edema	1047:1057	brain edema	1047:1057	Furthermore, brain edema and inflammatory reactions were significantly alleviated.
33200759	1	70	theme	novel	226:230	arg1	scaffold					243:250	a novel biological scaffold	224:250	a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI)	224:366	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33200759	2	71	theme	growth	476:481	arg1	factor					483:488	vascular endothelial growth factor	455:488	vascular endothelial growth factor	455:488	In our research, a functional composite scaffold constituted by collagen, heparin and vascular endothelial growth factor was used to stimulate angiogenesis and improve nerve-tissue regeneration in a rat model of TBI.
33200759	3	72	theme	composite	590:598	arg1	scaffold					600:607	The composite scaffold	586:607	The composite scaffold	586:607	The composite scaffold possessed excellent mechanical properties and good porosity, and could effectively control the release rate of VEGF.
33200759	1	73	theme	biological	232:241	arg1	scaffold					243:250	a novel biological scaffold	224:250	a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI)	224:366	The objective of this study was to evaluate the therapy effects of a novel biological scaffold containing heparin, collagen and vascular endothelial growth factor (VEGF) in treating traumatic brain injury (TBI).
33254992	5	0	theme	wound	1415:1419	arg1	site					1421:1424	chronic wound site	1407:1424	chronic wound site	1407:1424	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	5	1	theme	hydration	1194:1202	arg1	capacities					1204:1213	a significantly higher hydration capacities	1171:1213	a significantly higher hydration capacities	1171:1213	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	5	1	theme	hydration	1194:1202	arg1	content					1268:1274	equilibrium water content	1250:1274	equilibrium water content	1250:1274	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	5	1	theme	hydration	1194:1202	arg1	degree					1239:1244	the swelling degree	1226:1244	the swelling degree	1226:1244	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	4	2	theme	EGF	884:886	arg1	dosages					848:854	The optimal effective dosages	826:854	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture	826:914	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture were first determined based on the results of antibacterial, cytotoxicity, and cell growth examinations.
33254992	0	3	with	hydrogel	86:93	arg1	antimicrobility					110:124	sustained antimicrobility	100:124	sustained antimicrobility	100:124	Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing.
33254992	7	4	theme	sufficient	1903:1912	arg1	deposition					1923:1932	sufficient collagen deposition	1903:1932	sufficient collagen deposition	1903:1932	Moreover, the wound treated with the SNPECHG exhibited thorough re-epithelization, sufficient collagen deposition, and accelerated collagen maturation confirmed by the histological analysis.
33254992	5	5	theme	higher	1187:1192	arg1	capacities					1204:1213	a significantly higher hydration capacities	1171:1213	a significantly higher hydration capacities	1171:1213	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	5	5	theme	higher	1187:1192	arg1	content					1268:1274	equilibrium water content	1250:1274	equilibrium water content	1250:1274	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	5	5	theme	higher	1187:1192	arg1	degree					1239:1244	the swelling degree	1226:1244	the swelling degree	1226:1244	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	4	6	theme	24-mM	859:863	arg1	Ag+					865:867	24-mM Ag+	859:867	24-mM Ag+	859:867	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture were first determined based on the results of antibacterial, cytotoxicity, and cell growth examinations.
33254992	6	7	theme	dressing	1777:1784	arg1	HeraDerm					1786:1793	the commercial dressing HeraDerm	1762:1793	the commercial dressing HeraDerm	1762:1793	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	3	8	theme	epidermal	767:775	arg1	EGF					792:794	EGF	792:794	EGF	792:794	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	3	8	theme	epidermal	767:775	arg1	factor					784:789	nanoparticle-encapsulated epidermal growth factor	741:789	nanoparticle-encapsulated epidermal growth factor (EGF)	741:795	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	1	9	with	skin	296:299	arg1	rate					340:343	irregularly delayed wound healing rate	306:343	irregularly delayed wound healing rate due to impaired metabolism and weak immune responses	306:396	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	8	10	theme	diabetic/chronic	2109:2124	arg1	treatment					2132:2140	the clinical diabetic/chronic wound treatment	2096:2140	the clinical diabetic/chronic wound treatment	2096:2140	Taken all together, we anticipate that the SNPECHG is highly advantageous for use in the clinical diabetic/chronic wound treatment.
33254992	6	11	with	one	1494:1496	arg1	SNPECHG					1503:1509	SNPECHG	1503:1509	SNPECHG	1503:1509	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	6	12	theme	closure	1640:1646	arg1	degree					1624:1629	a degree	1622:1629	a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively	1622:1817	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	0	13	theme	diabetic	165:172	arg1	healing					180:186	diabetic wound healing	165:186	diabetic wound healing	165:186	Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing.
33254992	1	14	theme	diabetic	233:240	arg1	complications					242:254	the most common diabetic complications	217:254	the most common diabetic complications	217:254	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	8	15	from	use	2089:2091	arg1	treatment					2132:2140	the clinical diabetic/chronic wound treatment	2096:2140	the clinical diabetic/chronic wound treatment	2096:2140	Taken all together, we anticipate that the SNPECHG is highly advantageous for use in the clinical diabetic/chronic wound treatment.
33254992	3	16	theme	diabetic	621:628	arg1	healing					636:642	diabetic wound healing	621:642	diabetic wound healing	621:642	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	6	17	theme	wound	1541:1545	arg1	healing					1547:1553	a markedly enhanced wound healing	1521:1553	a markedly enhanced wound healing effect	1521:1560	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	0	18	theme	composite	76:84	arg1	hydrogel					86:93	chitosan composite hydrogel	67:93	chitosan composite hydrogel with sustained antimicrobility	67:124	Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing.
33254992	5	19	theme	equilibrium	1250:1260	arg1	content					1268:1274	equilibrium water content	1250:1274	equilibrium water content	1250:1274	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	1	20	theme	impaired	352:359	arg1	metabolism					361:370	impaired metabolism	352:370	impaired metabolism	352:370	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	1	21	theme	foot	198:201	arg1	one					210:212	one	210:212	one	210:212	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	1	21	theme	foot	198:201	arg1	wound					274:278	a progressive wound	260:278	a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses	260:396	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	1	21	theme	foot	198:201	arg1	ulcer					203:207	Diabetic foot ulcer	189:207	Diabetic foot ulcer	189:207	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	1	21	theme	foot	198:201	arg1	complications					242:254	the most common diabetic complications	217:254	the most common diabetic complications	217:254	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	6	22	from	day	1658:1660	arg1	closure					1640:1646	wound closure	1634:1646	wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively	1634:1817	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	6	22	from	day	1658:1660	arg1	%					1653:1653	97%	1651:1653	97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively	1651:1817	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	1	23	theme	immune	381:386	arg1	responses					388:396	weak immune responses	376:396	weak immune responses	376:396	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	2	24	theme	Such	399:402	arg1	wound					412:416	Such chronic wound	399:416	Such chronic wound	399:416	Such chronic wound remains a serious healthcare burden to the diabetics since it is often associated with high risk of limb loss due to amputation and leads to a reduced survival consequently.
33254992	0	25	theme	Novel	0:4	arg1	silver					6:11	Novel silver	0:11	Novel silver	0:11	Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing.
33254992	6	26	theme	other	1580:1584	arg1	settings					1586:1593	the other settings	1576:1593	the other settings since day 3	1576:1605	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	2	27	theme	healthcare	436:445	arg1	burden					447:452	a serious healthcare burden	426:452	a serious healthcare burden to the diabetics	426:469	Such chronic wound remains a serious healthcare burden to the diabetics since it is often associated with high risk of limb loss due to amputation and leads to a reduced survival consequently.
33254992	4	28	theme	cell	995:998	arg1	examinations					1007:1018	cell growth examinations	995:1018	cell growth examinations	995:1018	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture were first determined based on the results of antibacterial, cytotoxicity, and cell growth examinations.
33254992	0	29	theme	growth	43:48	arg1	factor					50:55	nanoparticle-encapsulated growth factor	17:55	nanoparticle-encapsulated growth factor	17:55	Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing.
33254992	1	30	theme	delayed	318:324	arg1	rate					340:343	irregularly delayed wound healing rate	306:343	irregularly delayed wound healing rate due to impaired metabolism and weak immune responses	306:396	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	4	31	theme	examinations	1007:1018	arg1	results					951:957	the results	947:957	the results of antibacterial, cytotoxicity, and cell growth examinations	947:1018	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture were first determined based on the results of antibacterial, cytotoxicity, and cell growth examinations.
33254992	5	32	theme	Ag+	1144:1146	arg1	release					1133:1139	sustained release	1123:1139	sustained release of Ag+ and EGF	1123:1154	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	3	33	theme	healing	636:642	arg1	efficiency					607:616	the efficiency	603:616	the efficiency of diabetic wound healing	603:642	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	4	34	theme	optimal	830:836	arg1	dosages					848:854	The optimal effective dosages	826:854	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture	826:914	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture were first determined based on the results of antibacterial, cytotoxicity, and cell growth examinations.
33254992	5	35	theme	EGF	1152:1154	arg1	release					1133:1139	sustained release	1123:1139	sustained release of Ag+ and EGF	1123:1154	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	5	36	theme	ion-rich	1378:1385	arg1	environment					1387:1397	the ion-rich environment	1374:1397	the ion-rich environment such as chronic wound site	1374:1424	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	6	37	theme	study	1463:1467	arg1	results					1444:1450	the results	1440:1450	the results of in vivo study using diabetic rats	1440:1487	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	1	38	theme	complications	242:254	arg1	one					210:212	one	210:212	one	210:212	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	1	38	theme	complications	242:254	arg1	complications					242:254	the most common diabetic complications	217:254	the most common diabetic complications	217:254	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	1	38	theme	complications	242:254	arg1	ulcer					203:207	Diabetic foot ulcer	189:207	Diabetic foot ulcer	189:207	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	3	39	theme	chitosan-based	657:670	arg1	hydrogel					682:689	a synthetic chitosan-based composite hydrogel	645:689	a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF)	645:795	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	6	40	theme	in	1455:1456	arg1	study					1463:1467	in vivo study	1455:1467	in vivo study using diabetic rats	1455:1487	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	5	41	theme	swelling	1230:1237	arg1	degree					1239:1244	the swelling degree	1226:1244	the swelling degree	1226:1244	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	3	42	theme	silver	719:724	arg1	Ag+					732:734	Ag+	732:734	Ag+	732:734	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	3	42	theme	silver	719:724	arg1	ions					726:729	silver ions	719:729	silver ions (Ag+)	719:735	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	1	43	theme	progressive	262:272	arg1	wound					274:278	a progressive wound	260:278	a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses	260:396	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	1	43	theme	progressive	262:272	arg1	ulcer					203:207	Diabetic foot ulcer	189:207	Diabetic foot ulcer	189:207	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	7	44	theme	accelerated	1939:1949	arg1	maturation					1960:1969	accelerated collagen maturation	1939:1969	accelerated collagen maturation	1939:1969	Moreover, the wound treated with the SNPECHG exhibited thorough re-epithelization, sufficient collagen deposition, and accelerated collagen maturation confirmed by the histological analysis.
33254992	4	45	theme	Ag+	865:867	arg1	dosages					848:854	The optimal effective dosages	826:854	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture	826:914	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture were first determined based on the results of antibacterial, cytotoxicity, and cell growth examinations.
33254992	6	46	theme	higher	1711:1716	arg1	P < 0.05					1701:1708	P < 0.05	1701:1708	P < 0.05	1701:1708	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	6	46	theme	higher	1711:1716	arg1	%					1698:1698	18.9%	1694:1698	18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze	1694:1803	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	4	47	theme	60-μg mL-1	873:882	arg1	EGF					884:886	60-μg mL-1 EGF	873:886	60-μg mL-1 EGF	873:886	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture were first determined based on the results of antibacterial, cytotoxicity, and cell growth examinations.
33254992	7	48	theme	collagen	1914:1921	arg1	deposition					1923:1932	sufficient collagen deposition	1903:1932	sufficient collagen deposition	1903:1932	Moreover, the wound treated with the SNPECHG exhibited thorough re-epithelization, sufficient collagen deposition, and accelerated collagen maturation confirmed by the histological analysis.
33254992	4	49	theme	effective	838:846	arg1	dosages					848:854	The optimal effective dosages	826:854	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture	826:914	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture were first determined based on the results of antibacterial, cytotoxicity, and cell growth examinations.
33254992	1	50	theme	healing	332:338	arg1	rate					340:343	irregularly delayed wound healing rate	306:343	irregularly delayed wound healing rate due to impaired metabolism and weak immune responses	306:396	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	6	51	theme	commercial	1766:1775	arg1	HeraDerm					1786:1793	the commercial dressing HeraDerm	1762:1793	the commercial dressing HeraDerm	1762:1793	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	3	52	theme	growth	777:782	arg1	EGF					792:794	EGF	792:794	EGF	792:794	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	3	52	theme	growth	777:782	arg1	factor					784:789	nanoparticle-encapsulated epidermal growth factor	741:789	nanoparticle-encapsulated epidermal growth factor (EGF)	741:795	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	5	53	from	capacities	1204:1213	arg1	PBS					1280:1282	PBS	1280:1282	PBS	1280:1282	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	5	54	theme	chronic	1407:1413	arg1	site					1421:1424	chronic wound site	1407:1424	chronic wound site	1407:1424	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	7	55	theme	thorough	1875:1882	arg1	re-epithelization					1884:1900	thorough re-epithelization	1875:1900	thorough re-epithelization	1875:1900	Moreover, the wound treated with the SNPECHG exhibited thorough re-epithelization, sufficient collagen deposition, and accelerated collagen maturation confirmed by the histological analysis.
33254992	8	56	theme	clinical	2100:2107	arg1	treatment					2132:2140	the clinical diabetic/chronic wound treatment	2096:2140	the clinical diabetic/chronic wound treatment	2096:2140	Taken all together, we anticipate that the SNPECHG is highly advantageous for use in the clinical diabetic/chronic wound treatment.
33254992	3	57	theme	nanoparticle-encapsulated	741:765	arg1	EGF					792:794	EGF	792:794	EGF	792:794	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	3	57	theme	nanoparticle-encapsulated	741:765	arg1	factor					784:789	nanoparticle-encapsulated epidermal growth factor	741:789	nanoparticle-encapsulated epidermal growth factor (EGF)	741:795	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	0	58	theme	wound	174:178	arg1	healing					180:186	diabetic wound healing	165:186	diabetic wound healing	165:186	Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing.
33254992	6	59	theme	diabetic	1475:1482	arg1	rats					1484:1487	diabetic rats	1475:1487	diabetic rats	1475:1487	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	1	60	theme	common	226:231	arg1	complications					242:254	the most common diabetic complications	217:254	the most common diabetic complications	217:254	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	6	61	theme	wound	1634:1638	arg1	closure					1640:1646	wound closure	1634:1646	wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively	1634:1817	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	8	62	theme	wound	2126:2130	arg1	treatment					2132:2140	the clinical diabetic/chronic wound treatment	2096:2140	the clinical diabetic/chronic wound treatment	2096:2140	Taken all together, we anticipate that the SNPECHG is highly advantageous for use in the clinical diabetic/chronic wound treatment.
33254992	5	63	theme	composite	1084:1092	arg1	able					1107:1110	able	1107:1110	able	1107:1110	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	5	63	theme	composite	1084:1092	arg1	hydrogel					1094:1101	the composite hydrogel	1080:1101	the composite hydrogel	1080:1101	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	2	64	theme	reduced	561:567	arg1	survival					569:576	a reduced survival	559:576	a reduced survival consequently	559:589	Such chronic wound remains a serious healthcare burden to the diabetics since it is often associated with high risk of limb loss due to amputation and leads to a reduced survival consequently.
33254992	5	65	theme	optimized	1047:1055	arg1	SNPECHG					1057:1063	the optimized SNPECHG	1043:1063	the optimized SNPECHG	1043:1063	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	6	66	theme	healing	1547:1553	arg1	effect					1555:1560	a markedly enhanced wound healing effect	1521:1560	a markedly enhanced wound healing effect	1521:1560	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	4	67	theme	SNPECHG	896:902	arg1	manufacture					904:914	the SNPECHG manufacture	892:914	the SNPECHG manufacture	892:914	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture were first determined based on the results of antibacterial, cytotoxicity, and cell growth examinations.
33254992	6	68	theme	enhanced	1532:1539	arg1	healing					1547:1553	a markedly enhanced wound healing	1521:1553	a markedly enhanced wound healing effect	1521:1560	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	2	69	theme	high	505:508	arg1	risk					510:513	high risk	505:513	high risk of limb loss due to amputation	505:544	Such chronic wound remains a serious healthcare burden to the diabetics since it is often associated with high risk of limb loss due to amputation and leads to a reduced survival consequently.
33254992	7	70	theme	histological	1988:1999	arg1	analysis					2001:2008	the histological analysis	1984:2008	the histological analysis	1984:2008	Moreover, the wound treated with the SNPECHG exhibited thorough re-epithelization, sufficient collagen deposition, and accelerated collagen maturation confirmed by the histological analysis.
33254992	0	71	theme	sustained	100:108	arg1	antimicrobility					110:124	sustained antimicrobility	100:124	sustained antimicrobility	100:124	Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing.
33254992	5	72	theme	sustained	1123:1131	arg1	release					1133:1139	sustained release	1123:1139	sustained release of Ag+ and EGF	1123:1154	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	1	73	theme	Diabetic	189:196	arg1	one					210:212	one	210:212	one	210:212	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	1	73	theme	Diabetic	189:196	arg1	wound					274:278	a progressive wound	260:278	a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses	260:396	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	1	73	theme	Diabetic	189:196	arg1	ulcer					203:207	Diabetic foot ulcer	189:207	Diabetic foot ulcer	189:207	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	1	73	theme	Diabetic	189:196	arg1	complications					242:254	the most common diabetic complications	217:254	the most common diabetic complications	217:254	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	4	74	theme	cytotoxicity	977:988	arg1	results					951:957	the results	947:957	the results of antibacterial, cytotoxicity, and cell growth examinations	947:1018	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture were first determined based on the results of antibacterial, cytotoxicity, and cell growth examinations.
33254992	5	75	theme	water	1262:1266	arg1	content					1268:1274	equilibrium water content	1250:1274	equilibrium water content	1250:1274	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	2	76	theme	loss	523:526	arg1	risk					510:513	high risk	505:513	high risk of limb loss due to amputation	505:544	Such chronic wound remains a serious healthcare burden to the diabetics since it is often associated with high risk of limb loss due to amputation and leads to a reduced survival consequently.
33254992	0	77	theme	biological	139:148	arg1	properties					150:159	biological properties	139:159	biological properties for diabetic wound healing	139:186	Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing.
33254992	1	78	theme	weak	376:379	arg1	responses					388:396	weak immune responses	376:396	weak immune responses	376:396	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	6	79	theme	%	1653:1653	arg1	closure					1640:1646	wound closure	1634:1646	wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively	1634:1817	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	2	80	theme	limb	518:521	arg1	loss					523:526	limb loss	518:526	limb loss	518:526	Such chronic wound remains a serious healthcare burden to the diabetics since it is often associated with high risk of limb loss due to amputation and leads to a reduced survival consequently.
33254992	0	81	theme	nanoparticle-encapsulated	17:41	arg1	factor					50:55	nanoparticle-encapsulated growth factor	17:55	nanoparticle-encapsulated growth factor	17:55	Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing.
33254992	6	82	from	closure	1640:1646	arg1	day					1658:1660	day 14	1658:1663	day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively	1658:1817	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	5	83	theme	deionized	1298:1306	arg1	water					1308:1312	deionized water	1298:1312	deionized water	1298:1312	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	2	84	theme	serious	428:434	arg1	burden					447:452	a serious healthcare burden	426:452	a serious healthcare burden to the diabetics	426:469	Such chronic wound remains a serious healthcare burden to the diabetics since it is often associated with high risk of limb loss due to amputation and leads to a reduced survival consequently.
33254992	5	85	from	applicable	1360:1369	arg1	environment					1387:1397	the ion-rich environment	1374:1397	the ion-rich environment such as chronic wound site	1374:1424	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	3	86	theme	wound	630:634	arg1	healing					636:642	diabetic wound healing	621:642	diabetic wound healing	621:642	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	0	87	theme	chitosan	67:74	arg1	hydrogel					86:93	chitosan composite hydrogel	67:93	chitosan composite hydrogel with sustained antimicrobility	67:124	Novel silver and nanoparticle-encapsulated growth factor co-loaded chitosan composite hydrogel with sustained antimicrobility and promoted biological properties for diabetic wound healing.
33254992	1	88	theme	wound	326:330	arg1	healing					332:338	wound healing	326:338	irregularly delayed wound healing rate due to impaired metabolism and weak immune responses	306:396	Diabetic foot ulcer, one of the most common diabetic complications, is a progressive wound occurred on the skin with irregularly delayed wound healing rate due to impaired metabolism and weak immune responses.
33254992	4	89	theme	growth	1000:1005	arg1	examinations					1007:1018	cell growth examinations	995:1018	cell growth examinations	995:1018	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture were first determined based on the results of antibacterial, cytotoxicity, and cell growth examinations.
33254992	3	90	theme	composite	672:680	arg1	hydrogel					682:689	a synthetic chitosan-based composite hydrogel	645:689	a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF)	645:795	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	4	91	theme	antibacterial	962:974	arg1	results					951:957	the results	947:957	the results of antibacterial, cytotoxicity, and cell growth examinations	947:1018	The optimal effective dosages of 24-mM Ag+ and 60-μg mL-1 EGF for the SNPECHG manufacture were first determined based on the results of antibacterial, cytotoxicity, and cell growth examinations.
33254992	5	92	from	environment	1387:1397	arg1	SNPECHG					1342:1348	the developed SNPECHG	1328:1348	the developed SNPECHG	1328:1348	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	5	92	from	environment	1387:1397	arg1	applicable					1360:1369	applicable	1360:1369	applicable	1360:1369	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	3	93	theme	synthetic	647:655	arg1	hydrogel					682:689	a synthetic chitosan-based composite hydrogel	645:689	a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF)	645:795	To improve the efficiency of diabetic wound healing, a synthetic chitosan-based composite hydrogel named SNPECHG incorporating silver ions (Ag+) and nanoparticle-encapsulated epidermal growth factor (EGF) was developed in this study.
33254992	5	94	theme	developed	1332:1340	arg1	SNPECHG					1342:1348	the developed SNPECHG	1328:1348	the developed SNPECHG	1328:1348	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	5	94	theme	developed	1332:1340	arg1	applicable					1360:1369	applicable	1360:1369	applicable	1360:1369	We then characterized the optimized SNPECHG and found that the composite hydrogel was able to provide sustained release of Ag+ and EGF, and exhibited a significantly higher hydration capacities, including the swelling degree and equilibrium water content, in PBS than those in deionized water, showing that the developed SNPECHG is highly applicable in the ion-rich environment such as chronic wound site.
33254992	7	95	theme	collagen	1951:1958	arg1	maturation					1960:1969	accelerated collagen maturation	1939:1969	accelerated collagen maturation	1939:1969	Moreover, the wound treated with the SNPECHG exhibited thorough re-epithelization, sufficient collagen deposition, and accelerated collagen maturation confirmed by the histological analysis.
33254992	6	96	dep	in	1455:1456	arg1	vivo					1458:1461	vivo	1458:1461	vivo	1458:1461	According to the results of in vivo study using diabetic rats, the one with SNPECHG exhibited a markedly enhanced wound healing effect compared with the other settings since day 3, and may reach a degree of wound closure of 97% at day 14 that was 7.4% (P < 0.05) and 18.9% (P < 0.05) higher than the values gained from the groups with the commercial dressing HeraDerm and gauze, respectively.
33254992	2	97	theme	chronic	404:410	arg1	wound					412:416	Such chronic wound	399:416	Such chronic wound	399:416	Such chronic wound remains a serious healthcare burden to the diabetics since it is often associated with high risk of limb loss due to amputation and leads to a reduced survival consequently.
34646251	3	0	theme	host	530:533	arg1	receptors					465:473	surface receptors	457:473	surface receptors	457:473	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	3	0	theme	host	530:533	arg1	roles					570:574	other roles	564:574	other roles in the struggle between host and microbe	564:615	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	3	0	theme	host	530:533	arg1	responses					542:550	host immune responses	530:550	host immune responses	530:550	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	3	0	theme	host	530:533	arg1	ligands					478:484	ligands	478:484	ligands	478:484	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	7	1	contain	have	1316:1319	arg2	potential					1325:1333	the potential to improve diagnosis and treatment of infections and immune dysregulation	1321:1407	the potential to improve diagnosis and treatment of infections and immune dysregulation	1321:1407	Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation.
34646251	7	1	contain	have	1316:1319	arg1	discoveries					1234:1244	Future discoveries	1227:1244	Future discoveries in these areas	1227:1259	Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation.
34646251	2	2	from	processes	342:350	arg1	central					327:333	central	327:333	central	327:333	These two disciplines overlap when microbial infection stimulates host immune responses and glycan structures are central in the processes that occur during all such encounters.
34646251	3	3	theme	immune	535:540	arg1	receptors					465:473	surface receptors	457:473	surface receptors	457:473	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	3	3	theme	immune	535:540	arg1	roles					570:574	other roles	564:574	other roles in the struggle between host and microbe	564:615	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	3	3	theme	immune	535:540	arg1	responses					542:550	host immune responses	530:550	host immune responses	530:550	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	3	3	theme	immune	535:540	arg1	ligands					478:484	ligands	478:484	ligands	478:484	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	7	4	theme	immune	1388:1393	arg1	dysregulation					1395:1407	immune dysregulation	1388:1407	immune dysregulation	1388:1407	Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation.
34646251	6	5	from	investigation	1088:1100	arg1	recognition					1201:1211	cell recognition	1196:1211	cell recognition	1196:1211	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	6	5	from	investigation	1088:1100	arg1	interactions					1145:1156	microbe-host interactions	1132:1156	microbe-host interactions	1132:1156	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	6	5	from	investigation	1088:1100	arg1	diseases					1175:1182	immune-mediated diseases	1159:1182	immune-mediated diseases	1159:1182	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	3	6	theme	other	564:568	arg1	receptors					465:473	surface receptors	457:473	surface receptors	457:473	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	3	6	theme	other	564:568	arg1	roles					570:574	other roles	564:574	other roles in the struggle between host and microbe	564:615	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	3	6	theme	other	564:568	arg1	responses					542:550	host immune responses	530:550	host immune responses	530:550	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	3	6	theme	other	564:568	arg1	ligands					478:484	ligands	478:484	ligands	478:484	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	2	7	from	central	327:333	arg1	processes					342:350	the processes	338:350	the processes that occur during all such encounters	338:388	These two disciplines overlap when microbial infection stimulates host immune responses and glycan structures are central in the processes that occur during all such encounters.
34646251	6	8	theme	cell	1196:1199	arg1	recognition					1201:1211	cell recognition	1196:1211	cell recognition	1196:1211	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	5	9	from	workshop	835:842	arg1	May					989:991	May 2020	989:996	May 2020	989:996	This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020.
34646251	7	10	theme	scientific	1287:1296	arg1	understanding					1298:1310	fundamental scientific understanding	1275:1310	fundamental scientific understanding	1275:1310	Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation.
34646251	5	11	theme	Dental	953:958	arg1	Research					977:984	Dental and Craniofacial Research	953:984	Dental and Craniofacial Research	953:984	This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020.
34646251	7	12	theme	Future	1227:1232	arg1	discoveries					1234:1244	Future discoveries	1227:1244	Future discoveries in these areas	1227:1259	Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation.
34646251	4	13	theme	mediators	794:802	arg1	effects					753:759	the effects	749:759	the effects of antibodies and soluble immune mediators	749:802	In the context of the host, glycosylation drives cell-cell interactions that initiate and regulate the host response and modulates the effects of antibodies and soluble immune mediators.
34646251	7	14	theme	infections	1373:1382	arg1	treatment					1360:1368	treatment	1360:1368	treatment	1360:1368	Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation.
34646251	7	14	theme	infections	1373:1382	arg1	diagnosis					1346:1354	diagnosis	1346:1354	diagnosis	1346:1354	Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation.
34646251	1	15	theme	broad	169:173	arg1	areas					175:179	the broad areas	165:179	the broad areas of immunology and microbiology	165:210	Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology.
34646251	2	16	theme	immune	284:289	arg1	responses					291:299	host immune responses	279:299	host immune responses	279:299	These two disciplines overlap when microbial infection stimulates host immune responses and glycan structures are central in the processes that occur during all such encounters.
34646251	6	17	theme	glycans	1105:1111	arg1	roles					1123:1127	their roles	1117:1127	their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function	1117:1224	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	6	17	theme	glycans	1105:1111	arg1	investigation					1088:1100	investigation	1088:1100	investigation of glycans	1088:1111	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	1	18	theme	experimental	71:82	arg1	capabilities					84:95	experimental capabilities	71:95	experimental capabilities	71:95	Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology.
34646251	5	19	theme	Allergy	891:897	arg1	Institute					878:886	the National Institute	865:886	the National Institute of Allergy and Infectious Diseases	865:921	This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020.
34646251	5	20	theme	Craniofacial	964:975	arg1	Research					977:984	Dental and Craniofacial Research	953:984	Dental and Craniofacial Research	953:984	This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020.
34646251	4	21	theme	soluble	779:785	arg1	mediators					794:802	soluble immune mediators	779:802	soluble immune mediators	779:802	In the context of the host, glycosylation drives cell-cell interactions that initiate and regulate the host response and modulates the effects of antibodies and soluble immune mediators.
34646251	3	22	theme	surface	457:463	arg1	receptors					465:473	surface receptors	457:473	surface receptors	457:473	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	3	22	theme	surface	457:463	arg1	roles					570:574	other roles	564:574	other roles in the struggle between host and microbe	564:615	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	3	22	theme	surface	457:463	arg1	responses					542:550	host immune responses	530:550	host immune responses	530:550	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	0	23	theme	Glycoscience	18:29	arg1	Crossroads					4:13	The Crossroads	0:13	The Crossroads of Glycoscience, Infection, and Immunology	0:56	The Crossroads of Glycoscience, Infection, and Immunology.
34646251	5	24	from	Institute	940:948	arg1	May					989:991	May 2020	989:996	May 2020	989:996	This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020.
34646251	4	25	theme	antibodies	764:773	arg1	effects					753:759	the effects	749:759	the effects of antibodies and soluble immune mediators	749:802	In the context of the host, glycosylation drives cell-cell interactions that initiate and regulate the host response and modulates the effects of antibodies and soluble immune mediators.
34646251	4	26	theme	host	640:643	arg1	context					625:631	the context	621:631	the context of the host	621:643	In the context of the host, glycosylation drives cell-cell interactions that initiate and regulate the host response and modulates the effects of antibodies and soluble immune mediators.
34646251	3	27	theme	Microbial	391:399	arg1	glycans					401:407	Microbial glycans	391:407	Microbial glycans	391:407	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	1	28	theme	microbiology	199:210	arg1	areas					175:179	the broad areas	165:179	the broad areas of immunology and microbiology	165:210	Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology.
34646251	0	29	theme	Infection	32:40	arg1	Crossroads					4:13	The Crossroads	0:13	The Crossroads of Glycoscience, Infection, and Immunology	0:56	The Crossroads of Glycoscience, Infection, and Immunology.
34646251	6	30	theme	immune-mediated	1159:1173	arg1	diseases					1175:1182	immune-mediated diseases	1159:1182	immune-mediated diseases	1159:1182	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	7	31	from	discoveries	1234:1244	arg1	areas					1255:1259	these areas	1249:1259	these areas	1249:1259	Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation.
34646251	1	32	theme	immunology	184:193	arg1	areas					175:179	the broad areas	165:179	the broad areas of immunology and microbiology	165:210	Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology.
34646251	6	33	theme	resources	1067:1075	arg1	use					1028:1030	the use	1024:1030	the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function	1024:1224	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	4	34	theme	cell-cell	667:675	arg1	interactions					677:688	cell-cell interactions	667:688	cell-cell interactions that initiate and regulate the host response	667:733	In the context of the host, glycosylation drives cell-cell interactions that initiate and regulate the host response and modulates the effects of antibodies and soluble immune mediators.
34646251	6	35	theme	emerging	1035:1042	arg1	tools					1057:1061	emerging glycoscience tools	1035:1061	emerging glycoscience tools	1035:1061	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	5	36	theme	National	869:876	arg1	Institute					878:886	the National Institute	865:886	the National Institute of Allergy and Infectious Diseases	865:921	This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020.
34646251	3	37	theme	host-pathogen	417:429	arg1	interactions					431:442	host-pathogen interactions	417:442	host-pathogen interactions	417:442	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	7	38	theme	fundamental	1275:1285	arg1	understanding					1298:1310	fundamental scientific understanding	1275:1310	fundamental scientific understanding	1275:1310	Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation.
34646251	6	39	theme	microbe-host	1132:1143	arg1	interactions					1145:1156	microbe-host interactions	1132:1156	microbe-host interactions	1132:1156	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	5	40	theme	National	931:938	arg1	Institute					940:948	the National Institute	927:948	the National Institute of Dental and Craniofacial Research in May 2020	927:996	This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020.
34646251	4	41	theme	host	721:724	arg1	response					726:733	the host response	717:733	the host response	717:733	In the context of the host, glycosylation drives cell-cell interactions that initiate and regulate the host response and modulates the effects of antibodies and soluble immune mediators.
34646251	2	42	theme	host	279:282	arg1	responses					291:299	host immune responses	279:299	host immune responses	279:299	These two disciplines overlap when microbial infection stimulates host immune responses and glycan structures are central in the processes that occur during all such encounters.
34646251	6	43	theme	glycoscience	1044:1055	arg1	tools					1057:1061	emerging glycoscience tools	1035:1061	emerging glycoscience tools	1035:1061	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	1	44	theme	expanding	124:132	arg1	opportunities					134:146	expanding opportunities	124:146	expanding opportunities for discovery	124:160	Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology.
34646251	5	45	theme	Research	977:984	arg1	Institute					940:948	the National Institute	927:948	the National Institute of Dental and Craniofacial Research in May 2020	927:996	This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020.
34646251	5	45	theme	Research	977:984	arg1	workshop					835:842	a workshop	833:842	a workshop organized jointly by the National Institute of Allergy and Infectious Diseases	833:921	This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020.
34646251	6	46	theme	tools	1057:1061	arg1	use					1028:1030	the use	1024:1030	the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function	1024:1224	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	4	47	theme	immune	787:792	arg1	mediators					794:802	soluble immune mediators	779:802	soluble immune mediators	779:802	In the context of the host, glycosylation drives cell-cell interactions that initiate and regulate the host response and modulates the effects of antibodies and soluble immune mediators.
34646251	2	48	theme	glycan	305:310	arg1	structures					312:321	glycan structures	305:321	glycan structures	305:321	These two disciplines overlap when microbial infection stimulates host immune responses and glycan structures are central in the processes that occur during all such encounters.
34646251	6	49	from	roles	1123:1127	arg1	recognition					1201:1211	cell recognition	1196:1211	cell recognition	1196:1211	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	6	49	from	roles	1123:1127	arg1	interactions					1145:1156	microbe-host interactions	1132:1156	microbe-host interactions	1132:1156	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	6	49	from	roles	1123:1127	arg1	diseases					1175:1182	immune-mediated diseases	1159:1182	immune-mediated diseases	1159:1182	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	5	50	theme	Diseases	914:921	arg1	Institute					878:886	the National Institute	865:886	the National Institute of Allergy and Infectious Diseases	865:921	This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020.
34646251	3	51	theme	virulence	502:510	arg1	factors					512:518	virulence factors	502:518	virulence factors	502:518	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	3	52	from	roles	570:574	arg1	struggle					583:590	the struggle	579:590	the struggle	579:590	Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe.
34646251	5	53	theme	Infectious	903:912	arg1	Diseases					914:921	Infectious Diseases	903:921	Infectious Diseases	903:921	This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020.
34646251	7	54	theme	dysregulation	1395:1407	arg1	treatment					1360:1368	treatment	1360:1368	treatment	1360:1368	Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation.
34646251	7	54	theme	dysregulation	1395:1407	arg1	diagnosis					1346:1354	diagnosis	1346:1354	diagnosis	1346:1354	Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation.
34646251	6	55	theme	immune	1189:1194	arg1	recognition					1201:1211	cell recognition	1196:1211	cell recognition	1196:1211	The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function.
34646251	0	56	theme	Immunology	47:56	arg1	Crossroads					4:13	The Crossroads	0:13	The Crossroads of Glycoscience, Infection, and Immunology	0:56	The Crossroads of Glycoscience, Infection, and Immunology.
34646251	2	57	theme	microbial	248:256	arg1	infection					258:266	microbial infection	248:266	microbial infection	248:266	These two disciplines overlap when microbial infection stimulates host immune responses and glycan structures are central in the processes that occur during all such encounters.
34646251	2	58	theme	such	374:377	arg1	encounters					379:388	all such encounters	370:388	all such encounters	370:388	These two disciplines overlap when microbial infection stimulates host immune responses and glycan structures are central in the processes that occur during all such encounters.
34646251	1	59	from	Advances	59:66	arg1	capabilities					84:95	experimental capabilities	71:95	experimental capabilities	71:95	Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology.
34646251	1	59	from	Advances	59:66	arg1	glycosciences					104:116	the glycosciences	100:116	the glycosciences	100:116	Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology.
33800798	2	0	theme	aqueous	377:383	arg1	solution					385:392	aqueous solution	377:392	aqueous solution	377:392	The uptake properties of these biodegradable polymer adsorbents were evaluated with a mixture of THMs in aqueous solution.
33800798	5	1	theme	Unique	765:770	arg1	characteristics					783:797	Unique adsorption characteristics	765:797	Unique adsorption characteristics	765:797	Unique adsorption characteristics were observed that vary according to the polymer structure, composition, and surface chemical properties.
33800798	6	2	theme	molecular	1059:1067	arg1	size					1069:1072	molecular size	1059:1072	molecular size	1059:1072	The modified polysaccharide adsorbents display variable molecular recognition and selectivity toward component THMs in the mixed systems according to the molecular size and polarizability of the adsorbates.
33800798	6	3	theme	molecular	961:969	arg1	recognition					971:981	variable molecular recognition	952:981	variable molecular recognition	952:981	The modified polysaccharide adsorbents display variable molecular recognition and selectivity toward component THMs in the mixed systems according to the molecular size and polarizability of the adsorbates.
33800798	2	4	from	mixture	358:364	arg1	solution					385:392	aqueous solution	377:392	aqueous solution	377:392	The uptake properties of these biodegradable polymer adsorbents were evaluated with a mixture of THMs in aqueous solution.
33800798	6	5	theme	variable	952:959	arg1	recognition					971:981	variable molecular recognition	952:981	variable molecular recognition	952:981	The modified polysaccharide adsorbents display variable molecular recognition and selectivity toward component THMs in the mixed systems according to the molecular size and polarizability of the adsorbates.
33800798	2	6	theme	polymer	317:323	arg1	adsorbents					325:334	these biodegradable polymer adsorbents	297:334	these biodegradable polymer adsorbents	297:334	The uptake properties of these biodegradable polymer adsorbents were evaluated with a mixture of THMs in aqueous solution.
33800798	4	7	dep	mmol	722:725	arg1	1.07					717:720	1.07	717:720	1.07	717:720	The adsorption isotherms for the polymer-THMs was evaluated using the Sips model, where the monolayer adsorption capacities ranged between 0.04 and 1.07 mmol THMs/g for respective component THMs.
33800798	4	7	dep	mmol	722:725	arg1	0.04					708:711	0.04	708:711	0.04	708:711	The adsorption isotherms for the polymer-THMs was evaluated using the Sips model, where the monolayer adsorption capacities ranged between 0.04 and 1.07 mmol THMs/g for respective component THMs.
33800798	2	8	theme	biodegradable	303:315	arg1	adsorbents					325:334	these biodegradable polymer adsorbents	297:334	these biodegradable polymer adsorbents	297:334	The uptake properties of these biodegradable polymer adsorbents were evaluated with a mixture of THMs in aqueous solution.
33800798	5	9	theme	chemical	884:891	arg1	properties					893:902	surface chemical properties	876:902	surface chemical properties	876:902	Unique adsorption characteristics were observed that vary according to the polymer structure, composition, and surface chemical properties.
33800798	3	10	theme	THMs	531:534	arg1	quantification					513:526	quantification	513:526	quantification of THMs in water	513:543	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection enabled quantification of THMs in water at 295 K and at pH 6.5.
33800798	1	11	from	samples	158:164	arg1	removal					106:112	The adsorptive removal	91:112	The adsorptive removal of trihalomethanes (THMs) from spiked water samples	91:164	The adsorptive removal of trihalomethanes (THMs) from spiked water samples was evaluated with a series of modified polysaccharide adsorbents that contain β-cylodextrin or chitosan.
33800798	4	12	theme	adsorption	671:680	arg1	capacities					682:691	the monolayer adsorption capacities	657:691	the monolayer adsorption capacities	657:691	The adsorption isotherms for the polymer-THMs was evaluated using the Sips model, where the monolayer adsorption capacities ranged between 0.04 and 1.07 mmol THMs/g for respective component THMs.
33800798	3	13	theme	aqueous	433:439	arg1	DAI					452:454	DAI	452:454	DAI	452:454	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection enabled quantification of THMs in water at 295 K and at pH 6.5.
33800798	3	13	theme	aqueous	433:439	arg1	injection					441:449	direct aqueous injection	426:449	a direct aqueous injection (DAI) method with electrolytic conductivity detection	424:503	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection enabled quantification of THMs in water at 295 K and at pH 6.5.
33800798	6	14	theme	polysaccharide	918:931	arg1	adsorbents					933:942	The modified polysaccharide adsorbents	905:942	The modified polysaccharide adsorbents	905:942	The modified polysaccharide adsorbents display variable molecular recognition and selectivity toward component THMs in the mixed systems according to the molecular size and polarizability of the adsorbates.
33800798	3	15	from	quantification	513:526	arg1	water					539:543	water	539:543	water	539:543	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection enabled quantification of THMs in water at 295 K and at pH 6.5.
33800798	1	16	theme	adsorptive	95:104	arg1	removal					106:112	The adsorptive removal	91:112	The adsorptive removal of trihalomethanes (THMs) from spiked water samples	91:164	The adsorptive removal of trihalomethanes (THMs) from spiked water samples was evaluated with a series of modified polysaccharide adsorbents that contain β-cylodextrin or chitosan.
33800798	4	17	theme	monolayer	661:669	arg1	capacities					682:691	the monolayer adsorption capacities	657:691	the monolayer adsorption capacities	657:691	The adsorption isotherms for the polymer-THMs was evaluated using the Sips model, where the monolayer adsorption capacities ranged between 0.04 and 1.07 mmol THMs/g for respective component THMs.
33800798	6	18	theme	modified	909:916	arg1	adsorbents					933:942	The modified polysaccharide adsorbents	905:942	The modified polysaccharide adsorbents	905:942	The modified polysaccharide adsorbents display variable molecular recognition and selectivity toward component THMs in the mixed systems according to the molecular size and polarizability of the adsorbates.
33800798	6	19	dep	size	1069:1072	arg1	the					1055:1057	the	1055:1057	the	1055:1057	The modified polysaccharide adsorbents display variable molecular recognition and selectivity toward component THMs in the mixed systems according to the molecular size and polarizability of the adsorbates.
33800798	0	20	theme	Adsorption	0:9	arg1	Studies					11:17	Adsorption Studies	0:17	Adsorption Studies of Waterborne Trihalomethanes Using Modified Polysaccharide Adsorbents.	0:89	Adsorption Studies of Waterborne Trihalomethanes Using Modified Polysaccharide Adsorbents.
33800798	3	21	from	THMs	531:534	arg1	water					539:543	water	539:543	water	539:543	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection enabled quantification of THMs in water at 295 K and at pH 6.5.
33800798	4	22	theme	component	749:757	arg1	THMs					759:762	respective component THMs	738:762	respective component THMs	738:762	The adsorption isotherms for the polymer-THMs was evaluated using the Sips model, where the monolayer adsorption capacities ranged between 0.04 and 1.07 mmol THMs/g for respective component THMs.
33800798	3	23	theme	Gas	395:397	arg1	chromatography					399:412	Gas chromatography	395:412	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection	395:503	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection enabled quantification of THMs in water at 295 K and at pH 6.5.
33800798	5	24	theme	polymer	840:846	arg1	structure					848:856	the polymer structure	836:856	the polymer structure	836:856	Unique adsorption characteristics were observed that vary according to the polymer structure, composition, and surface chemical properties.
33800798	1	25	theme	trihalomethanes	117:131	arg1	removal					106:112	The adsorptive removal	91:112	The adsorptive removal of trihalomethanes (THMs) from spiked water samples	91:164	The adsorptive removal of trihalomethanes (THMs) from spiked water samples was evaluated with a series of modified polysaccharide adsorbents that contain β-cylodextrin or chitosan.
33800798	3	26	from	water	539:543	arg1	quantification					513:526	quantification	513:526	quantification of THMs in water	513:543	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection enabled quantification of THMs in water at 295 K and at pH 6.5.
33800798	1	27	theme	modified	197:204	arg1	adsorbents					221:230	modified polysaccharide adsorbents	197:230	modified polysaccharide adsorbents that contain β-cylodextrin or chitosan	197:269	The adsorptive removal of trihalomethanes (THMs) from spiked water samples was evaluated with a series of modified polysaccharide adsorbents that contain β-cylodextrin or chitosan.
33800798	2	28	theme	adsorbents	325:334	arg1	properties					283:292	The uptake properties	272:292	The uptake properties of these biodegradable polymer adsorbents	272:334	The uptake properties of these biodegradable polymer adsorbents were evaluated with a mixture of THMs in aqueous solution.
33800798	1	29	theme	polysaccharide	206:219	arg1	adsorbents					221:230	modified polysaccharide adsorbents	197:230	modified polysaccharide adsorbents that contain β-cylodextrin or chitosan	197:269	The adsorptive removal of trihalomethanes (THMs) from spiked water samples was evaluated with a series of modified polysaccharide adsorbents that contain β-cylodextrin or chitosan.
33800798	3	30	theme	injection	441:449	arg1	method					457:462	a direct aqueous injection (DAI) method	424:462	a direct aqueous injection (DAI) method with electrolytic conductivity detection	424:503	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection enabled quantification of THMs in water at 295 K and at pH 6.5.
33800798	4	31	theme	adsorption	573:582	arg1	isotherms					584:592	The adsorption isotherms	569:592	The adsorption isotherms for the polymer-THMs	569:613	The adsorption isotherms for the polymer-THMs was evaluated using the Sips model, where the monolayer adsorption capacities ranged between 0.04 and 1.07 mmol THMs/g for respective component THMs.
33800798	3	32	theme	electrolytic	469:480	arg1	detection					495:503	electrolytic conductivity detection	469:503	electrolytic conductivity detection	469:503	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection enabled quantification of THMs in water at 295 K and at pH 6.5.
33800798	1	33	theme	adsorbents	221:230	arg1	series					187:192	a series	185:192	a series of modified polysaccharide adsorbents that contain β-cylodextrin or chitosan	185:269	The adsorptive removal of trihalomethanes (THMs) from spiked water samples was evaluated with a series of modified polysaccharide adsorbents that contain β-cylodextrin or chitosan.
33800798	0	34	theme	Trihalomethanes	33:47	arg1	Studies					11:17	Adsorption Studies	0:17	Adsorption Studies of Waterborne Trihalomethanes Using Modified Polysaccharide Adsorbents.	0:89	Adsorption Studies of Waterborne Trihalomethanes Using Modified Polysaccharide Adsorbents.
33800798	0	35	theme	Waterborne	22:31	arg1	Trihalomethanes					33:47	Waterborne Trihalomethanes	22:47	Waterborne Trihalomethanes	22:47	Adsorption Studies of Waterborne Trihalomethanes Using Modified Polysaccharide Adsorbents.
33800798	3	36	theme	conductivity	482:493	arg1	detection					495:503	electrolytic conductivity detection	469:503	electrolytic conductivity detection	469:503	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection enabled quantification of THMs in water at 295 K and at pH 6.5.
33800798	0	37	theme	Polysaccharide	64:77	arg1	Adsorbents					79:88	Modified Polysaccharide Adsorbents	55:88	Modified Polysaccharide Adsorbents	55:88	Adsorption Studies of Waterborne Trihalomethanes Using Modified Polysaccharide Adsorbents.
33800798	6	38	theme	component	1006:1014	arg1	THMs					1016:1019	component THMs	1006:1019	component THMs	1006:1019	The modified polysaccharide adsorbents display variable molecular recognition and selectivity toward component THMs in the mixed systems according to the molecular size and polarizability of the adsorbates.
33800798	6	39	theme	mixed	1028:1032	arg1	systems					1034:1040	the mixed systems	1024:1040	the mixed systems according to the molecular size and polarizability of the adsorbates	1024:1109	The modified polysaccharide adsorbents display variable molecular recognition and selectivity toward component THMs in the mixed systems according to the molecular size and polarizability of the adsorbates.
33800798	2	40	theme	THMs	369:372	arg1	mixture					358:364	a mixture	356:364	a mixture of THMs in aqueous solution	356:392	The uptake properties of these biodegradable polymer adsorbents were evaluated with a mixture of THMs in aqueous solution.
33800798	0	41	theme	Modified	55:62	arg1	Adsorbents					79:88	Modified Polysaccharide Adsorbents	55:88	Modified Polysaccharide Adsorbents	55:88	Adsorption Studies of Waterborne Trihalomethanes Using Modified Polysaccharide Adsorbents.
33800798	1	42	contain	contain	237:243	arg2	chitosan					262:269	chitosan	262:269	chitosan	262:269	The adsorptive removal of trihalomethanes (THMs) from spiked water samples was evaluated with a series of modified polysaccharide adsorbents that contain β-cylodextrin or chitosan.
33800798	1	42	contain	contain	237:243	arg1	adsorbents					221:230	modified polysaccharide adsorbents	197:230	modified polysaccharide adsorbents that contain β-cylodextrin or chitosan	197:269	The adsorptive removal of trihalomethanes (THMs) from spiked water samples was evaluated with a series of modified polysaccharide adsorbents that contain β-cylodextrin or chitosan.
33800798	1	42	contain	contain	237:243	arg2	β-cylodextrin					245:257	β-cylodextrin	245:257	β-cylodextrin	245:257	The adsorptive removal of trihalomethanes (THMs) from spiked water samples was evaluated with a series of modified polysaccharide adsorbents that contain β-cylodextrin or chitosan.
33800798	3	43	with	method	457:462	arg1	detection					495:503	electrolytic conductivity detection	469:503	electrolytic conductivity detection	469:503	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection enabled quantification of THMs in water at 295 K and at pH 6.5.
33800798	4	44	theme	respective	738:747	arg1	THMs					759:762	respective component THMs	738:762	respective component THMs	738:762	The adsorption isotherms for the polymer-THMs was evaluated using the Sips model, where the monolayer adsorption capacities ranged between 0.04 and 1.07 mmol THMs/g for respective component THMs.
33800798	4	45	dep	THMs/g	727:732	arg1	mmol					722:725	mmol	722:725	mmol	722:725	The adsorption isotherms for the polymer-THMs was evaluated using the Sips model, where the monolayer adsorption capacities ranged between 0.04 and 1.07 mmol THMs/g for respective component THMs.
33800798	2	46	theme	uptake	276:281	arg1	properties					283:292	The uptake properties	272:292	The uptake properties of these biodegradable polymer adsorbents	272:334	The uptake properties of these biodegradable polymer adsorbents were evaluated with a mixture of THMs in aqueous solution.
33800798	1	47	theme	spiked	145:150	arg1	samples					158:164	spiked water samples	145:164	spiked water samples	145:164	The adsorptive removal of trihalomethanes (THMs) from spiked water samples was evaluated with a series of modified polysaccharide adsorbents that contain β-cylodextrin or chitosan.
33800798	5	48	theme	adsorption	772:781	arg1	characteristics					783:797	Unique adsorption characteristics	765:797	Unique adsorption characteristics	765:797	Unique adsorption characteristics were observed that vary according to the polymer structure, composition, and surface chemical properties.
33800798	5	49	theme	surface	876:882	arg1	properties					893:902	surface chemical properties	876:902	surface chemical properties	876:902	Unique adsorption characteristics were observed that vary according to the polymer structure, composition, and surface chemical properties.
33800798	1	50	theme	water	152:156	arg1	samples					158:164	spiked water samples	145:164	spiked water samples	145:164	The adsorptive removal of trihalomethanes (THMs) from spiked water samples was evaluated with a series of modified polysaccharide adsorbents that contain β-cylodextrin or chitosan.
33800798	4	51	theme	Sips	639:642	arg1	model					644:648	the Sips model	635:648	the Sips model	635:648	The adsorption isotherms for the polymer-THMs was evaluated using the Sips model, where the monolayer adsorption capacities ranged between 0.04 and 1.07 mmol THMs/g for respective component THMs.
33800798	3	52	theme	direct	426:431	arg1	DAI					452:454	DAI	452:454	DAI	452:454	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection enabled quantification of THMs in water at 295 K and at pH 6.5.
33800798	3	52	theme	direct	426:431	arg1	injection					441:449	direct aqueous injection	426:449	a direct aqueous injection (DAI) method with electrolytic conductivity detection	424:503	Gas chromatography employing a direct aqueous injection (DAI) method with electrolytic conductivity detection enabled quantification of THMs in water at 295 K and at pH 6.5.
33800798	6	53	theme	adsorbates	1100:1109	arg1	polarizability					1078:1091	polarizability	1078:1091	polarizability	1078:1091	The modified polysaccharide adsorbents display variable molecular recognition and selectivity toward component THMs in the mixed systems according to the molecular size and polarizability of the adsorbates.
33800798	6	53	theme	adsorbates	1100:1109	arg1	size					1069:1072	molecular size	1059:1072	molecular size	1059:1072	The modified polysaccharide adsorbents display variable molecular recognition and selectivity toward component THMs in the mixed systems according to the molecular size and polarizability of the adsorbates.
32854588	9	0	theme	combination	1642:1652	arg1	structure					1625:1633	the structure	1621:1633	the structure of the combination of crosslinked HA with blood-derived protein	1621:1697	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	9	1	theme	crosslinked	1558:1568	arg1	acid					1581:1584	crosslinked hyaluronic acid	1558:1584	crosslinked hyaluronic acid (HA)	1558:1589	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	9	1	theme	crosslinked	1558:1568	arg1	HA					1587:1588	HA	1587:1588	HA	1587:1588	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	8	2	dep	biocompatible	1416:1428	arg1	remodeling					1431:1440	remodeling	1431:1440	remodeling	1431:1440	The scaffold was proven to be biocompatible, remodeling, and vascularization occurred, while shape and integrity were maintained.
32854588	8	2	dep	biocompatible	1416:1428	arg1	biocompatible					1416:1428	biocompatible	1416:1428	biocompatible	1416:1428	The scaffold was proven to be biocompatible, remodeling, and vascularization occurred, while shape and integrity were maintained.
32854588	8	2	dep	biocompatible	1416:1428	arg1	scaffold					1390:1397	The scaffold	1386:1397	The scaffold	1386:1397	The scaffold was proven to be biocompatible, remodeling, and vascularization occurred, while shape and integrity were maintained.
32854588	0	3	theme	Tissue	80:85	arg1	Regeneration					87:98	Soft Tissue Regeneration	75:98	Soft Tissue Regeneration	75:98	Crosslinked Hyaluronic Acid Gels with Blood-Derived Protein Components for Soft Tissue Regeneration.
32854588	9	4	theme	crosslinked	1657:1667	arg1	HA					1669:1670	crosslinked HA	1657:1670	crosslinked HA with blood-derived protein	1657:1697	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	4	5	theme	chemical	760:767	arg1	changes					769:775	The chemical changes	756:775	The chemical changes	756:775	The chemical changes were characterized and cell attachment capacity of the protein-containing gels was examined using human mesenchymal stem cells, and viability was assessed using live-dead staining.
32854588	10	6	theme	stem	1812:1815	arg1	attachment					1822:1831	better mesenchymal stem cell attachment	1793:1831	better mesenchymal stem cell attachment	1793:1831	It was observed that the fibrin content led to better mesenchymal stem cell attachment in vitro.
32854588	12	7	theme	potential	2021:2029	arg1	which					2010:2014	which	2010:2014	which	2010:2014	Thus, a biocompatible, injectable gel was produced, which is a potential candidate for soft tissue implantation.
32854588	12	7	theme	potential	2021:2029	arg1	candidate					2031:2039	a potential candidate	2019:2039	a potential candidate for soft tissue implantation	2019:2068	Thus, a biocompatible, injectable gel was produced, which is a potential candidate for soft tissue implantation.
32854588	2	8	from	effect	424:429	arg1	properties					438:447	the properties	434:447	the properties of HA hydrogels	434:463	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	4	9	theme	live-dead	938:946	arg1	staining					948:955	live-dead staining	938:955	live-dead staining	938:955	The chemical changes were characterized and cell attachment capacity of the protein-containing gels was examined using human mesenchymal stem cells, and viability was assessed using live-dead staining.
32854588	4	10	theme	stem	893:896	arg1	cells					898:902	human mesenchymal stem cells	875:902	human mesenchymal stem cells	875:902	The chemical changes were characterized and cell attachment capacity of the protein-containing gels was examined using human mesenchymal stem cells, and viability was assessed using live-dead staining.
32854588	4	11	theme	human	875:879	arg1	cells					898:902	human mesenchymal stem cells	875:902	human mesenchymal stem cells	875:902	The chemical changes were characterized and cell attachment capacity of the protein-containing gels was examined using human mesenchymal stem cells, and viability was assessed using live-dead staining.
32854588	2	12	used	used	398:401	arg2	sulfone					346:352	divinyl sulfone	338:352	divinyl sulfone (DVS)	338:358	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	2	12	used	used	398:401	arg2	ether					386:390	butanediol diglycidyl ether	364:390	butanediol diglycidyl ether	364:390	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	2	12	used	used	398:401	arg2	agents					330:335	two crosslinking agents	313:335	two crosslinking agents	313:335	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	12	13	dep	biocompatible	1966:1978	arg1	injectable					1981:1990	injectable	1981:1990	injectable	1981:1990	Thus, a biocompatible, injectable gel was produced, which is a potential candidate for soft tissue implantation.
32854588	11	14	theme	connective	1885:1894	arg1	tissue					1896:1901	connective tissue	1885:1901	connective tissue	1885:1901	The compositions showed biocompatibility, connective tissue and vascularization took place when implanted in vivo.
32854588	11	15	dep	showed	1860:1865	arg1	took					1923:1926	took	1923:1926	showed biocompatibility, connective tissue and vascularization took place when implanted in vivo	1860:1955	The compositions showed biocompatibility, connective tissue and vascularization took place when implanted in vivo.
32854588	7	16	link	DVS-crosslinked	1282:1296	arg1	derivative					1267:1276	The most promising derivative	1248:1276	The most promising derivative	1248:1276	The most promising derivative, 5% DVS-crosslinked fibrin-containing hydrogel, was injected subcutaneously into C57BL/6 mice for 12 weeks.
32854588	7	16	link	DVS-crosslinked	1282:1296	arg1	hydrogel					1316:1323	5% DVS-crosslinked fibrin-containing hydrogel	1279:1323	5% DVS-crosslinked fibrin-containing hydrogel	1279:1323	The most promising derivative, 5% DVS-crosslinked fibrin-containing hydrogel, was injected subcutaneously into C57BL/6 mice for 12 weeks.
32854588	6	17	theme	best	1168:1171	arg1	result					1173:1178	the best result	1164:1178	the best result	1164:1178	The scaffolds were found to be able to support cell adherence onto the hydrogels, and the best result was achieved when HA was crosslinked with DVS and contained fibrin.
32854588	10	18	theme	mesenchymal	1800:1810	arg1	attachment					1822:1831	better mesenchymal stem cell attachment	1793:1831	better mesenchymal stem cell attachment	1793:1831	It was observed that the fibrin content led to better mesenchymal stem cell attachment in vitro.
32854588	0	19	theme	Hyaluronic	12:21	arg1	Gels					28:31	Hyaluronic Acid Gels	12:31	Hyaluronic Acid Gels	12:31	Crosslinked Hyaluronic Acid Gels with Blood-Derived Protein Components for Soft Tissue Regeneration.
32854588	9	20	theme	blood-derived	1677:1689	arg1	protein					1691:1697	blood-derived protein	1677:1697	blood-derived protein	1677:1697	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	12	21	theme	biocompatible	1966:1978	arg1	gel					1992:1994	a biocompatible, injectable gel	1964:1994	a biocompatible, injectable gel	1964:1994	Thus, a biocompatible, injectable gel was produced, which is a potential candidate for soft tissue implantation.
32854588	0	22	theme	Soft	75:78	arg1	Regeneration					87:98	Soft Tissue Regeneration	75:98	Soft Tissue Regeneration	75:98	Crosslinked Hyaluronic Acid Gels with Blood-Derived Protein Components for Soft Tissue Regeneration.
32854588	3	23	from	fibrin	570:575	arg1	fibrin					534:539	fibrin	534:539	fibrin	534:539	As HA hydrogels alone do not promote cell adhesion on the scaffold, fibrin and serum from platelet-rich fibrin (SPRF) were combined with the scaffold; the aim was to create a material intended to be used as soft tissue implant that facilitates new tissue formation, and degrades over time.
32854588	3	23	from	fibrin	570:575	arg1	serum					545:549	serum	545:549	serum	545:549	As HA hydrogels alone do not promote cell adhesion on the scaffold, fibrin and serum from platelet-rich fibrin (SPRF) were combined with the scaffold; the aim was to create a material intended to be used as soft tissue implant that facilitates new tissue formation, and degrades over time.
32854588	12	24	theme	tissue	2050:2055	arg1	implantation					2057:2068	soft tissue implantation	2045:2068	soft tissue implantation	2045:2068	Thus, a biocompatible, injectable gel was produced, which is a potential candidate for soft tissue implantation.
32854588	10	25	theme	cell	1817:1820	arg1	attachment					1822:1831	better mesenchymal stem cell attachment	1793:1831	better mesenchymal stem cell attachment	1793:1831	It was observed that the fibrin content led to better mesenchymal stem cell attachment in vitro.
32854588	1	26	theme	advantageous	249:260	arg1	properties					286:295	their advantageous physical and biological properties	243:295	their advantageous physical and biological properties	243:295	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	9	27	theme	regenerative	1595:1606	arg1	application					1608:1618	regenerative application	1595:1618	regenerative application	1595:1618	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	1	28	theme	Hyaluronic	101:110	arg1	material					142:149	an ideal initial material	125:149	an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties	125:295	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	1	28	theme	Hyaluronic	101:110	arg1	HA					118:119	HA	118:119	HA	118:119	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	1	28	theme	Hyaluronic	101:110	arg1	acid					112:115	Hyaluronic acid	101:115	Hyaluronic acid (HA)	101:120	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	9	29	theme	hyaluronic	1570:1579	arg1	acid					1581:1584	crosslinked hyaluronic acid	1558:1584	crosslinked hyaluronic acid (HA)	1558:1589	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	9	29	theme	hyaluronic	1570:1579	arg1	HA					1587:1588	HA	1587:1588	HA	1587:1588	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	1	30	theme	physical	262:269	arg1	properties					286:295	their advantageous physical and biological properties	243:295	their advantageous physical and biological properties	243:295	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	9	31	theme	statement	1523:1531	arg1	Fibrin					1533:1538	Impact statement Fibrin	1516:1538	Impact statement Fibrin	1516:1538	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	3	32	theme	cell	503:506	arg1	adhesion					508:515	cell adhesion	503:515	cell adhesion	503:515	As HA hydrogels alone do not promote cell adhesion on the scaffold, fibrin and serum from platelet-rich fibrin (SPRF) were combined with the scaffold; the aim was to create a material intended to be used as soft tissue implant that facilitates new tissue formation, and degrades over time.
32854588	0	33	theme	Acid	23:26	arg1	Gels					28:31	Hyaluronic Acid Gels	12:31	Hyaluronic Acid Gels	12:31	Crosslinked Hyaluronic Acid Gels with Blood-Derived Protein Components for Soft Tissue Regeneration.
32854588	10	34	theme	better	1793:1798	arg1	attachment					1822:1831	better mesenchymal stem cell attachment	1793:1831	better mesenchymal stem cell attachment	1793:1831	It was observed that the fibrin content led to better mesenchymal stem cell attachment in vitro.
32854588	3	35	theme	HA	469:470	arg1	hydrogels					472:480	HA hydrogels	469:480	HA hydrogels	469:480	As HA hydrogels alone do not promote cell adhesion on the scaffold, fibrin and serum from platelet-rich fibrin (SPRF) were combined with the scaffold; the aim was to create a material intended to be used as soft tissue implant that facilitates new tissue formation, and degrades over time.
32854588	0	36	theme	Blood-Derived	38:50	arg1	Components					60:69	Blood-Derived Protein Components	38:69	Blood-Derived Protein Components for Soft Tissue Regeneration	38:98	Crosslinked Hyaluronic Acid Gels with Blood-Derived Protein Components for Soft Tissue Regeneration.
32854588	1	37	theme	biological	275:284	arg1	properties					286:295	their advantageous physical and biological properties	243:295	their advantageous physical and biological properties	243:295	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	4	38	theme	gels	851:854	arg1	capacity					816:823	cell attachment capacity	800:823	cell attachment capacity of the protein-containing gels	800:854	The chemical changes were characterized and cell attachment capacity of the protein-containing gels was examined using human mesenchymal stem cells, and viability was assessed using live-dead staining.
32854588	9	39	link	crosslinked	1558:1568	arg1	acid					1581:1584	crosslinked hyaluronic acid	1558:1584	crosslinked hyaluronic acid (HA)	1558:1589	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	9	39	link	crosslinked	1558:1568	arg1	HA					1587:1588	HA	1587:1588	HA	1587:1588	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	7	40	theme	%	1280:1280	arg1	derivative					1267:1276	The most promising derivative	1248:1276	The most promising derivative	1248:1276	The most promising derivative, 5% DVS-crosslinked fibrin-containing hydrogel, was injected subcutaneously into C57BL/6 mice for 12 weeks.
32854588	7	40	theme	%	1280:1280	arg1	hydrogel					1316:1323	5% DVS-crosslinked fibrin-containing hydrogel	1279:1323	5% DVS-crosslinked fibrin-containing hydrogel	1279:1323	The most promising derivative, 5% DVS-crosslinked fibrin-containing hydrogel, was injected subcutaneously into C57BL/6 mice for 12 weeks.
32854588	12	41	theme	soft	2045:2048	arg1	implantation					2057:2068	soft tissue implantation	2045:2068	soft tissue implantation	2045:2068	Thus, a biocompatible, injectable gel was produced, which is a potential candidate for soft tissue implantation.
32854588	2	42	theme	diglycidyl	375:384	arg1	ether					386:390	butanediol diglycidyl ether	364:390	butanediol diglycidyl ether	364:390	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	2	42	theme	diglycidyl	375:384	arg1	agents					330:335	two crosslinking agents	313:335	two crosslinking agents	313:335	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	9	43	link	crosslinked	1657:1667	arg1	HA					1669:1670	crosslinked HA	1657:1670	crosslinked HA with blood-derived protein	1657:1697	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	3	44	theme	tissue	678:683	arg1	implant					685:691	soft tissue implant	673:691	soft tissue implant that facilitates new tissue formation, and degrades over time	673:753	As HA hydrogels alone do not promote cell adhesion on the scaffold, fibrin and serum from platelet-rich fibrin (SPRF) were combined with the scaffold; the aim was to create a material intended to be used as soft tissue implant that facilitates new tissue formation, and degrades over time.
32854588	4	45	theme	protein-containing	832:849	arg1	gels					851:854	the protein-containing gels	828:854	the protein-containing gels	828:854	The chemical changes were characterized and cell attachment capacity of the protein-containing gels was examined using human mesenchymal stem cells, and viability was assessed using live-dead staining.
32854588	1	46	used	used	189:192	arg2	scaffolds					197:205	scaffolds	197:205	scaffolds in soft tissue engineering based on their advantageous physical and biological properties	197:295	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	1	46	used	used	189:192	arg2	hydrogels					165:173	hydrogels	165:173	hydrogels	165:173	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	2	47	theme	butanediol	364:373	arg1	ether					386:390	butanediol diglycidyl ether	364:390	butanediol diglycidyl ether	364:390	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	2	47	theme	butanediol	364:373	arg1	agents					330:335	two crosslinking agents	313:335	two crosslinking agents	313:335	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	4	48	theme	cell	800:803	arg1	capacity					816:823	cell attachment capacity	800:823	cell attachment capacity of the protein-containing gels	800:854	The chemical changes were characterized and cell attachment capacity of the protein-containing gels was examined using human mesenchymal stem cells, and viability was assessed using live-dead staining.
32854588	4	49	theme	mesenchymal	881:891	arg1	cells					898:902	human mesenchymal stem cells	875:902	human mesenchymal stem cells	875:902	The chemical changes were characterized and cell attachment capacity of the protein-containing gels was examined using human mesenchymal stem cells, and viability was assessed using live-dead staining.
32854588	9	50	theme	Impact	1516:1521	arg1	Fibrin					1533:1538	Impact statement Fibrin	1516:1538	Impact statement Fibrin	1516:1538	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	9	51	link	blood-derived	1677:1689	arg1	protein					1691:1697	blood-derived protein	1677:1697	blood-derived protein	1677:1697	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	2	52	theme	crosslinking	317:328	arg1	ether					386:390	butanediol diglycidyl ether	364:390	butanediol diglycidyl ether	364:390	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	2	52	theme	crosslinking	317:328	arg1	agents					330:335	two crosslinking agents	313:335	two crosslinking agents	313:335	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	2	52	theme	crosslinking	317:328	arg1	sulfone					346:352	divinyl sulfone	338:352	divinyl sulfone (DVS)	338:358	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	0	53	theme	Protein	52:58	arg1	Components					60:69	Blood-Derived Protein Components	38:69	Blood-Derived Protein Components for Soft Tissue Regeneration	38:98	Crosslinked Hyaluronic Acid Gels with Blood-Derived Protein Components for Soft Tissue Regeneration.
32854588	10	54	theme	fibrin	1771:1776	arg1	content					1778:1784	the fibrin content	1767:1784	the fibrin content	1767:1784	It was observed that the fibrin content led to better mesenchymal stem cell attachment in vitro.
32854588	5	55	theme	Fourier-transform	958:974	arg1	measurements					985:996	Fourier-transform infrared measurements	958:996	Fourier-transform infrared measurements	958:996	Fourier-transform infrared measurements revealed that linking fibrin into the gel was more effective than linking SPRF.
32854588	7	56	theme	5	1279:1279	arg1	%					1280:1280	%	1280:1280	%	1280:1280	The most promising derivative, 5% DVS-crosslinked fibrin-containing hydrogel, was injected subcutaneously into C57BL/6 mice for 12 weeks.
32854588	3	57	theme	soft	673:676	arg1	implant					685:691	soft tissue implant	673:691	soft tissue implant that facilitates new tissue formation, and degrades over time	673:753	As HA hydrogels alone do not promote cell adhesion on the scaffold, fibrin and serum from platelet-rich fibrin (SPRF) were combined with the scaffold; the aim was to create a material intended to be used as soft tissue implant that facilitates new tissue formation, and degrades over time.
32854588	1	58	from	scaffolds	197:205	arg1	engineering					222:232	soft tissue engineering	210:232	soft tissue engineering based on their advantageous physical and biological properties	210:295	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	5	59	theme	infrared	976:983	arg1	measurements					985:996	Fourier-transform infrared measurements	958:996	Fourier-transform infrared measurements	958:996	Fourier-transform infrared measurements revealed that linking fibrin into the gel was more effective than linking SPRF.
32854588	3	60	theme	platelet-rich	556:568	arg1	SPRF					578:581	SPRF	578:581	SPRF	578:581	As HA hydrogels alone do not promote cell adhesion on the scaffold, fibrin and serum from platelet-rich fibrin (SPRF) were combined with the scaffold; the aim was to create a material intended to be used as soft tissue implant that facilitates new tissue formation, and degrades over time.
32854588	3	60	theme	platelet-rich	556:568	arg1	fibrin					570:575	platelet-rich fibrin	556:575	platelet-rich fibrin (SPRF)	556:582	As HA hydrogels alone do not promote cell adhesion on the scaffold, fibrin and serum from platelet-rich fibrin (SPRF) were combined with the scaffold; the aim was to create a material intended to be used as soft tissue implant that facilitates new tissue formation, and degrades over time.
32854588	7	61	theme	DVS-crosslinked	1282:1296	arg1	derivative					1267:1276	The most promising derivative	1248:1276	The most promising derivative	1248:1276	The most promising derivative, 5% DVS-crosslinked fibrin-containing hydrogel, was injected subcutaneously into C57BL/6 mice for 12 weeks.
32854588	7	61	theme	DVS-crosslinked	1282:1296	arg1	hydrogel					1316:1323	5% DVS-crosslinked fibrin-containing hydrogel	1279:1323	5% DVS-crosslinked fibrin-containing hydrogel	1279:1323	The most promising derivative, 5% DVS-crosslinked fibrin-containing hydrogel, was injected subcutaneously into C57BL/6 mice for 12 weeks.
32854588	7	62	theme	fibrin-containing	1298:1314	arg1	derivative					1267:1276	The most promising derivative	1248:1276	The most promising derivative	1248:1276	The most promising derivative, 5% DVS-crosslinked fibrin-containing hydrogel, was injected subcutaneously into C57BL/6 mice for 12 weeks.
32854588	7	62	theme	fibrin-containing	1298:1314	arg1	hydrogel					1316:1323	5% DVS-crosslinked fibrin-containing hydrogel	1279:1323	5% DVS-crosslinked fibrin-containing hydrogel	1279:1323	The most promising derivative, 5% DVS-crosslinked fibrin-containing hydrogel, was injected subcutaneously into C57BL/6 mice for 12 weeks.
32854588	3	63	theme	new	710:712	arg1	formation					721:729	new tissue formation	710:729	new tissue formation	710:729	As HA hydrogels alone do not promote cell adhesion on the scaffold, fibrin and serum from platelet-rich fibrin (SPRF) were combined with the scaffold; the aim was to create a material intended to be used as soft tissue implant that facilitates new tissue formation, and degrades over time.
32854588	4	64	theme	attachment	805:814	arg1	capacity					816:823	cell attachment capacity	800:823	cell attachment capacity of the protein-containing gels	800:854	The chemical changes were characterized and cell attachment capacity of the protein-containing gels was examined using human mesenchymal stem cells, and viability was assessed using live-dead staining.
32854588	6	65	theme	cell	1125:1128	arg1	adherence					1130:1138	cell adherence	1125:1138	cell adherence onto the hydrogels	1125:1157	The scaffolds were found to be able to support cell adherence onto the hydrogels, and the best result was achieved when HA was crosslinked with DVS and contained fibrin.
32854588	1	66	theme	initial	134:140	arg1	acid					112:115	Hyaluronic acid	101:115	Hyaluronic acid (HA)	101:120	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	1	66	theme	initial	134:140	arg1	material					142:149	an ideal initial material	125:149	an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties	125:295	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	9	67	theme	effective	1716:1724	arg1	coating					1726:1732	effective coating	1716:1732	effective coating	1716:1732	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	3	68	theme	tissue	714:719	arg1	formation					721:729	new tissue formation	710:729	new tissue formation	710:729	As HA hydrogels alone do not promote cell adhesion on the scaffold, fibrin and serum from platelet-rich fibrin (SPRF) were combined with the scaffold; the aim was to create a material intended to be used as soft tissue implant that facilitates new tissue formation, and degrades over time.
32854588	2	69	theme	hydrogels	455:463	arg1	properties					438:447	the properties	434:447	the properties of HA hydrogels	434:463	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	7	70	theme	C57BL/6	1359:1365	arg1	mice					1367:1370	C57BL/6 mice	1359:1370	C57BL/6 mice	1359:1370	The most promising derivative, 5% DVS-crosslinked fibrin-containing hydrogel, was injected subcutaneously into C57BL/6 mice for 12 weeks.
32854588	9	71	theme	HA	1669:1670	arg1	combination					1642:1652	the combination	1638:1652	the combination of crosslinked HA with blood-derived protein	1638:1697	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	1	72	theme	ideal	128:132	arg1	acid					112:115	Hyaluronic acid	101:115	Hyaluronic acid (HA)	101:120	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	1	72	theme	ideal	128:132	arg1	material					142:149	an ideal initial material	125:149	an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties	125:295	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	1	73	theme	soft	210:213	arg1	engineering					222:232	soft tissue engineering	210:232	soft tissue engineering based on their advantageous physical and biological properties	210:295	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
32854588	2	74	theme	HA	452:453	arg1	hydrogels					455:463	HA hydrogels	452:463	HA hydrogels	452:463	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	7	75	theme	promising	1257:1265	arg1	derivative					1267:1276	The most promising derivative	1248:1276	The most promising derivative	1248:1276	The most promising derivative, 5% DVS-crosslinked fibrin-containing hydrogel, was injected subcutaneously into C57BL/6 mice for 12 weeks.
32854588	7	75	theme	promising	1257:1265	arg1	hydrogel					1316:1323	5% DVS-crosslinked fibrin-containing hydrogel	1279:1323	5% DVS-crosslinked fibrin-containing hydrogel	1279:1323	The most promising derivative, 5% DVS-crosslinked fibrin-containing hydrogel, was injected subcutaneously into C57BL/6 mice for 12 weeks.
32854588	9	76	with	HA	1669:1670	arg1	protein					1691:1697	blood-derived protein	1677:1697	blood-derived protein	1677:1697	Impact statement Fibrin was combined with crosslinked hyaluronic acid (HA) for regenerative application, the structure of the combination of crosslinked HA with blood-derived protein was analyzed and effective coating was proven.
32854588	2	77	theme	divinyl	338:344	arg1	DVS					355:357	DVS	355:357	DVS	355:357	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	2	77	theme	divinyl	338:344	arg1	agents					330:335	two crosslinking agents	313:335	two crosslinking agents	313:335	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	2	77	theme	divinyl	338:344	arg1	sulfone					346:352	divinyl sulfone	338:352	divinyl sulfone (DVS)	338:358	In this study, two crosslinking agents, divinyl sulfone (DVS) and butanediol diglycidyl ether, were used to investigate their effect on the properties of HA hydrogels.
32854588	1	78	theme	tissue	215:220	arg1	engineering					222:232	soft tissue engineering	210:232	soft tissue engineering based on their advantageous physical and biological properties	210:295	Hyaluronic acid (HA) is an ideal initial material for preparing hydrogels, which may be used as scaffolds in soft tissue engineering based on their advantageous physical and biological properties.
34346527	3	0	attach	present	757:763	arg1	beads					736:740	those beads	730:740	those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin	730:980	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	3	0	attach	present	757:763	arg2	it					751:752	it	751:752	it	751:752	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	6	1	dep	show	1314:1317	arg1	whereas					1367:1373	whereas	1367:1373	whereas	1367:1373	The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, whereas the three-component DBS-COOH/DBS-CONHNH2 /alginate system shows controlled slow release of the API under the same conditions.
34346527	1	2	theme	calcium	189:195	arg1	alginate					197:204	the polymer gelator calcium alginate	169:204	the polymer gelator calcium alginate	169:204	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	3	3	theme	preliminary	799:809	arg1	data					811:814	preliminary data	799:814	preliminary data for a potential application for these hybrid gel beads	799:869	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	3	4	theme	different	619:627	arg1	formulations					638:649	The different gel bead formulations	615:649	The different gel bead formulations	615:649	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	1	5	theme	different	215:223	arg1	LMWGs					256:260	LMWGs	256:260	LMWGs	256:260	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	1	5	theme	different	215:223	arg1	gelators					246:253	two different low-molecular-weight gelators	211:253	two different low-molecular-weight gelators (LMWGs) based on 1,3 	211:275	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	4	6	theme	process	1133:1139	arg1	control					1117:1123	primary control	1109:1123	primary control of this process	1109:1139	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	3	7	theme	potential	822:830	arg1	application					832:842	a potential application	820:842	a potential application for these hybrid gel beads	820:869	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	6	8	theme	drug	1343:1346	arg1	release					1348:1354	rapid, highly effective drug release	1319:1354	rapid, highly effective drug release	1319:1354	The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, whereas the three-component DBS-COOH/DBS-CONHNH2 /alginate system shows controlled slow release of the API under the same conditions.
34346527	3	9	from	present	757:763	arg1	beads					736:740	those beads	730:740	those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin	730:980	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	1	10	theme	gel	451:453	arg1	beads					455:459	gel beads	451:459	gel beads	451:459	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	3	11	theme	bead	633:636	arg1	formulations					638:649	The different gel bead formulations	615:649	The different gel bead formulations	615:649	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	1	12	theme	pH-responsive	128:140	arg1	beads					153:157	new pH-responsive hybrid gel beads	124:157	new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 	124:275	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	7	13	theme	controlled	1649:1658	arg1	applications					1674:1685	controlled drug-delivery applications	1649:1685	controlled drug-delivery applications	1649:1685	These initial results indicate that such gel beads constitute a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications.
34346527	3	14	theme	hybrid	854:859	arg1	beads					865:869	these hybrid gel beads	848:869	these hybrid gel beads	848:869	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	6	15	theme	rapid	1319:1323	arg1	release					1348:1354	rapid, highly effective drug release	1319:1354	rapid, highly effective drug release	1319:1354	The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, whereas the three-component DBS-COOH/DBS-CONHNH2 /alginate system shows controlled slow release of the API under the same conditions.
34346527	4	16	from	pH 4.0	1100:1105	arg1	pH-dependent					1047:1058	pH-dependent	1047:1058	pH-dependent	1047:1058	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	4	16	from	pH 4.0	1100:1105	arg1	profile					995:1001	The release profile	983:1001	The release profile of this statin from the hybrid gel beads	983:1042	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	1	17	dep	fabrication	109:119	arg1	DBS-COOH					322:329	pH-responsive DBS-COOH	308:329	pH-responsive DBS-COOH	308:329	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	1	17	dep	fabrication	109:119	arg1	DBS-CONHNH2					356:366	thermally responsive DBS-CONHNH2	335:366	thermally responsive DBS-CONHNH2	335:366	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	1	17	dep	fabrication	109:119	arg1	 2,4-dibenzylidene-d-sorbitol					277:305	 2,4-dibenzylidene-d-sorbitol	277:305	the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2	105:366	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	3	18	theme	lipid-lowering	915:928	arg1	rosuvastatin					969:980	the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin	911:980	the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin	911:980	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	2	19	theme	gel	540:542	arg1	beads					544:548	self-assembled multicomponent gel beads	510:548	self-assembled multicomponent gel beads	510:548	We also demonstrate that self-assembled multicomponent gel beads can be formed by using different combinations of these gelators.
34346527	5	20	theme	bead	1268:1271	arg1	composition					1273:1283	gel bead composition	1264:1283	gel bead composition	1264:1283	The extent of pH-mediated API release is also significantly further modified according to gel bead composition.
34346527	6	21	theme	DBS-COOH/DBS-CONHNH2	1395:1414	arg1	system					1426:1431	the three-component DBS-COOH/DBS-CONHNH2 /alginate system	1375:1431	the three-component DBS-COOH/DBS-CONHNH2 /alginate system	1375:1431	The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, whereas the three-component DBS-COOH/DBS-CONHNH2 /alginate system shows controlled slow release of the API under the same conditions.
34346527	1	22	theme	polymer	173:179	arg1	alginate					197:204	the polymer gelator calcium alginate	169:204	the polymer gelator calcium alginate	169:204	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	1	23	theme	different	402:410	arg1	classes					412:418	different classes	402:418	different classes of LMWG	402:426	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	1	24	theme	gel	149:151	arg1	beads					153:157	new pH-responsive hybrid gel beads	124:157	new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 	124:275	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	3	25	theme	pharmaceutical	937:950	arg1	API					964:966	API	964:966	API	964:966	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	3	25	theme	pharmaceutical	937:950	arg1	ingredient					952:961	active pharmaceutical ingredient	930:961	the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin	911:980	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	0	26	theme	Hybrid	0:5	arg1	Beads					26:30	Hybrid Self-Assembled Gel Beads	0:30	Hybrid Self-Assembled Gel Beads	0:30	Hybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery.
34346527	0	27	theme	Gel	22:24	arg1	Beads					26:30	Hybrid Self-Assembled Gel Beads	0:30	Hybrid Self-Assembled Gel Beads	0:30	Hybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery.
34346527	5	28	theme	pH-mediated	1188:1198	arg1	release					1204:1210	pH-mediated API release	1188:1210	pH-mediated API release	1188:1210	The extent of pH-mediated API release is also significantly further modified according to gel bead composition.
34346527	2	29	theme	self-assembled	510:523	arg1	beads					544:548	self-assembled multicomponent gel beads	510:548	self-assembled multicomponent gel beads	510:548	We also demonstrate that self-assembled multicomponent gel beads can be formed by using different combinations of these gelators.
34346527	6	30	theme	controlled	1439:1448	arg1	release					1455:1461	controlled slow release	1439:1461	controlled slow release of the API	1439:1472	The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, whereas the three-component DBS-COOH/DBS-CONHNH2 /alginate system shows controlled slow release of the API under the same conditions.
34346527	4	31	from	beads	1038:1042	arg1	pH-dependent					1047:1058	pH-dependent	1047:1058	pH-dependent	1047:1058	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	4	31	from	beads	1038:1042	arg1	profile					995:1001	The release profile	983:1001	The release profile of this statin from the hybrid gel beads	983:1042	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	7	32	theme	such	1537:1540	arg1	beads					1546:1550	such gel beads	1537:1550	such gel beads	1537:1550	These initial results indicate that such gel beads constitute a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications.
34346527	0	33	theme	Rosuvastatin	59:70	arg1	Delivery					72:79	Tuneable pH-Controlled Rosuvastatin Delivery	36:79	Tuneable pH-Controlled Rosuvastatin Delivery	36:79	Hybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery.
34346527	3	34	from	beads	736:740	arg1	present					757:763	present	757:763	present	757:763	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	4	35	theme	hybrid	1027:1032	arg1	beads					1038:1042	the hybrid gel beads	1023:1042	the hybrid gel beads	1023:1042	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	5	36	theme	release	1204:1210	arg1	extent					1178:1183	The extent	1174:1183	The extent of pH-mediated API release	1174:1210	The extent of pH-mediated API release is also significantly further modified according to gel bead composition.
34346527	7	37	theme	initial	1507:1513	arg1	results					1515:1521	These initial results	1501:1521	These initial results	1501:1521	These initial results indicate that such gel beads constitute a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications.
34346527	6	38	theme	DBS-COOH/alginate	1290:1306	arg1	beads					1308:1312	The DBS-COOH/alginate beads	1286:1312	The DBS-COOH/alginate beads	1286:1312	The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, whereas the three-component DBS-COOH/DBS-CONHNH2 /alginate system shows controlled slow release of the API under the same conditions.
34346527	6	39	theme	same	1484:1487	arg1	conditions					1489:1498	the same conditions	1480:1498	the same conditions	1480:1498	The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, whereas the three-component DBS-COOH/DBS-CONHNH2 /alginate system shows controlled slow release of the API under the same conditions.
34346527	1	40	theme	gelator	181:187	arg1	alginate					197:204	the polymer gelator calcium alginate	169:204	the polymer gelator calcium alginate	169:204	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	0	41	theme	pH-Controlled	45:57	arg1	Delivery					72:79	Tuneable pH-Controlled Rosuvastatin Delivery	36:79	Tuneable pH-Controlled Rosuvastatin Delivery	36:79	Hybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery.
34346527	4	42	with	pH-dependent	1047:1058	arg1	release					1074:1080	greater release	1066:1080	greater release at pH 7.4	1066:1090	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	6	43	dep	rapid	1319:1323	arg1	effective					1333:1341	effective	1333:1341	effective	1333:1341	The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, whereas the three-component DBS-COOH/DBS-CONHNH2 /alginate system shows controlled slow release of the API under the same conditions.
34346527	1	44	theme	low-molecular-weight	225:244	arg1	LMWGs					256:260	LMWGs	256:260	LMWGs	256:260	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	1	44	theme	low-molecular-weight	225:244	arg1	gelators					246:253	two different low-molecular-weight gelators	211:253	two different low-molecular-weight gelators (LMWGs) based on 1,3 	211:275	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	7	45	theme	drug-delivery	1660:1672	arg1	applications					1674:1685	controlled drug-delivery applications	1649:1685	controlled drug-delivery applications	1649:1685	These initial results indicate that such gel beads constitute a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications.
34346527	2	46	theme	different	573:581	arg1	combinations					583:594	different combinations	573:594	different combinations of these gelators	573:612	We also demonstrate that self-assembled multicomponent gel beads can be formed by using different combinations of these gelators.
34346527	6	47	theme	three-component	1379:1393	arg1	system					1426:1431	the three-component DBS-COOH/DBS-CONHNH2 /alginate system	1375:1431	the three-component DBS-COOH/DBS-CONHNH2 /alginate system	1375:1431	The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, whereas the three-component DBS-COOH/DBS-CONHNH2 /alginate system shows controlled slow release of the API under the same conditions.
34346527	3	48	theme	gel	629:631	arg1	formulations					638:649	The different gel bead formulations	615:649	The different gel bead formulations	615:649	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	1	49	theme	new	124:126	arg1	beads					153:157	new pH-responsive hybrid gel beads	124:157	new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 	124:275	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	1	50	theme	hybrid	142:147	arg1	beads					153:157	new pH-responsive hybrid gel beads	124:157	new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 	124:275	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	3	51	theme	delivery	899:906	arg1	aspects					884:890	aspects	884:890	aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin	884:980	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	7	52	theme	further	1625:1631	arg1	development					1633:1643	further development	1625:1643	further development for controlled drug-delivery applications	1625:1685	These initial results indicate that such gel beads constitute a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications.
34346527	2	53	theme	gelators	605:612	arg1	combinations					583:594	different combinations	573:594	different combinations of these gelators	573:612	We also demonstrate that self-assembled multicomponent gel beads can be formed by using different combinations of these gelators.
34346527	4	54	theme	API	1169:1171	arg1	pKa					1158:1160	the pKa	1154:1160	the pKa of the API	1154:1171	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	3	55	theme	gel	861:863	arg1	beads					865:869	these hybrid gel beads	848:869	these hybrid gel beads	848:869	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	3	56	theme	different	659:667	arg1	responsiveness					669:682	different responsiveness	659:682	different responsiveness	659:682	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	1	57	theme	beads	153:157	arg1	fabrication					109:119	the fabrication	105:119	the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2	105:366	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	7	58	theme	suitable	1612:1619	arg1	platform					1603:1610	a promising, versatile and easily tuned platform	1563:1610	a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications	1563:1685	These initial results indicate that such gel beads constitute a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications.
34346527	4	59	theme	statin	1011:1016	arg1	pH-dependent					1047:1058	pH-dependent	1047:1058	pH-dependent	1047:1058	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	4	59	theme	statin	1011:1016	arg1	profile					995:1001	The release profile	983:1001	The release profile of this statin from the hybrid gel beads	983:1042	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	5	60	theme	gel	1264:1266	arg1	composition					1273:1283	gel bead composition	1264:1283	gel bead composition	1264:1283	The extent of pH-mediated API release is also significantly further modified according to gel bead composition.
34346527	6	61	theme	/alginate	1416:1424	arg1	system					1426:1431	the three-component DBS-COOH/DBS-CONHNH2 /alginate system	1375:1431	the three-component DBS-COOH/DBS-CONHNH2 /alginate system	1375:1431	The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, whereas the three-component DBS-COOH/DBS-CONHNH2 /alginate system shows controlled slow release of the API under the same conditions.
34346527	4	62	from	pH 7.4	1085:1090	arg1	release					1074:1080	greater release	1066:1080	greater release at pH 7.4	1066:1090	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	3	63	theme	active	930:935	arg1	API					964:966	API	964:966	API	964:966	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	3	63	theme	active	930:935	arg1	ingredient					952:961	active pharmaceutical ingredient	930:961	the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin	911:980	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	7	64	theme	tuned	1597:1601	arg1	platform					1603:1610	a promising, versatile and easily tuned platform	1563:1610	a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications	1563:1685	These initial results indicate that such gel beads constitute a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications.
34346527	2	65	theme	multicomponent	525:538	arg1	beads					544:548	self-assembled multicomponent gel beads	510:548	self-assembled multicomponent gel beads	510:548	We also demonstrate that self-assembled multicomponent gel beads can be formed by using different combinations of these gelators.
34346527	3	66	located	present	757:763	arg1	beads					736:740	those beads	730:740	those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin	730:980	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	3	66	located	present	757:763	arg2	it					751:752	it	751:752	it	751:752	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	4	67	theme	release	987:993	arg1	pH-dependent					1047:1058	pH-dependent	1047:1058	pH-dependent	1047:1058	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	4	67	theme	release	987:993	arg1	profile					995:1001	The release profile	983:1001	The release profile of this statin from the hybrid gel beads	983:1042	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	0	68	theme	Self-Assembled	7:20	arg1	Beads					26:30	Hybrid Self-Assembled Gel Beads	0:30	Hybrid Self-Assembled Gel Beads	0:30	Hybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery.
34346527	1	69	theme	LMWG	423:426	arg1	classes					412:418	different classes	402:418	different classes of LMWG	402:426	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	3	70	theme	ingredient	952:961	arg1	rosuvastatin					969:980	the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin	911:980	the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin	911:980	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	6	71	theme	API	1470:1472	arg1	release					1455:1461	controlled slow release	1439:1461	controlled slow release of the API	1439:1472	The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, whereas the three-component DBS-COOH/DBS-CONHNH2 /alginate system shows controlled slow release of the API under the same conditions.
34346527	1	72	theme	pH-responsive	308:320	arg1	DBS-COOH					322:329	pH-responsive DBS-COOH	308:329	pH-responsive DBS-COOH	308:329	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	4	73	theme	greater	1066:1072	arg1	release					1074:1080	greater release	1066:1080	greater release at pH 7.4	1066:1090	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	0	74	theme	Tuneable	36:43	arg1	Delivery					72:79	Tuneable pH-Controlled Rosuvastatin Delivery	36:79	Tuneable pH-Controlled Rosuvastatin Delivery	36:79	Hybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery.
34346527	5	75	theme	API	1200:1202	arg1	release					1204:1210	pH-mediated API release	1188:1210	pH-mediated API release	1188:1210	The extent of pH-mediated API release is also significantly further modified according to gel bead composition.
34346527	7	76	theme	versatile	1576:1584	arg1	platform					1603:1610	a promising, versatile and easily tuned platform	1563:1610	a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications	1563:1685	These initial results indicate that such gel beads constitute a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications.
34346527	3	77	theme	rosuvastatin	969:980	arg1	delivery					899:906	the delivery	895:906	the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin	895:980	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	4	78	theme	gel	1034:1036	arg1	beads					1038:1042	the hybrid gel beads	1023:1042	the hybrid gel beads	1023:1042	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
34346527	3	79	theme	DBS-COOH	690:697	arg1	network					699:705	the DBS-COOH network	686:705	the DBS-COOH network	686:705	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	6	80	theme	slow	1450:1453	arg1	release					1455:1461	controlled slow release	1439:1461	controlled slow release of the API	1439:1472	The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, whereas the three-component DBS-COOH/DBS-CONHNH2 /alginate system shows controlled slow release of the API under the same conditions.
34346527	1	81	theme	responsive	345:354	arg1	DBS-CONHNH2					356:366	thermally responsive DBS-CONHNH2	335:366	thermally responsive DBS-CONHNH2	335:366	This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH2 , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach.
34346527	7	82	theme	promising	1565:1573	arg1	platform					1603:1610	a promising, versatile and easily tuned platform	1563:1610	a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications	1563:1685	These initial results indicate that such gel beads constitute a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications.
34346527	3	83	dep	pH.	782:784	arg1	explored					875:882	explored	875:882	explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin	875:980	The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin.
34346527	0	84	dep	Beads	26:30	arg1	Delivery					72:79	Tuneable pH-Controlled Rosuvastatin Delivery	36:79	Tuneable pH-Controlled Rosuvastatin Delivery	36:79	Hybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery.
34346527	7	85	theme	gel	1542:1544	arg1	beads					1546:1550	such gel beads	1537:1550	such gel beads	1537:1550	These initial results indicate that such gel beads constitute a promising, versatile and easily tuned platform suitable for further development for controlled drug-delivery applications.
34346527	4	86	theme	primary	1109:1115	arg1	control					1117:1123	primary control	1109:1123	primary control of this process	1109:1139	The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 - primary control of this process results from the pKa of the API.
33076225	0	0	theme	Polymers	101:108	arg1	Production					54:63	Production	54:63	Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties	54:138	Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties.
33076225	4	1	with	films	685:689	arg1	starch					696:701	starch	696:701	starch to chitosan mass ratios of 1:1 and 1:2	696:740	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively.
33076225	1	2	theme	solvent	177:183	arg1	SSI					199:201	SSI	199:201	SSI	199:201	In the present study, supercritical solvent impregnation (SSI) has been applied to incorporate thymol into bio-composite polymers as a potential active packaging material.
33076225	1	2	theme	solvent	177:183	arg1	impregnation					185:196	supercritical solvent impregnation	163:196	supercritical solvent impregnation (SSI)	163:202	In the present study, supercritical solvent impregnation (SSI) has been applied to incorporate thymol into bio-composite polymers as a potential active packaging material.
33076225	0	3	theme	Starch-Chitosan	85:99	arg1	Polymers					101:108	Zeolite Modified Starch-Chitosan Polymers	68:108	Zeolite Modified Starch-Chitosan Polymers	68:108	Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties.
33076225	4	4	theme	impregnation	659:670	arg1	yields					672:677	The highest impregnation yields	647:677	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2	647:740	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively.
33076225	4	4	theme	impregnation	659:670	arg1	%					752:752	10.80%	747:752	10.80%	747:752	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively.
33076225	5	5	from	incorporation	890:902	arg1	quantity					909:916	a quantity	907:916	a quantity of 16.7-27.3%	907:930	The addition of natural zeolite (15-60%) significantly increased the loading capacity of films enabling thymol incorporation in a quantity of 16.7-27.3%.
33076225	0	6	theme	Antibacterial	115:127	arg1	Properties					129:138	Antibacterial Properties	115:138	Antibacterial Properties	115:138	Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties.
33076225	4	7	theme	1:2	738:740	arg1	ratios					720:725	chitosan mass ratios	706:725	chitosan mass ratios of 1:1 and 1:2	706:740	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively.
33076225	7	8	theme	water	1033:1037	arg1	properties					1018:1027	Mechanical properties	1007:1027	Mechanical properties	1007:1027	Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well.
33076225	7	8	theme	water	1033:1037	arg1	permeability					1045:1056	water vapor permeability	1033:1056	water vapor permeability	1033:1056	Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well.
33076225	7	8	theme	water	1033:1037	arg1	well					1116:1119	well	1116:1119	well	1116:1119	Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well.
33076225	5	9	theme	thymol	883:888	arg1	incorporation					890:902	thymol incorporation	883:902	thymol incorporation in a quantity of 16.7-27.3%	883:930	The addition of natural zeolite (15-60%) significantly increased the loading capacity of films enabling thymol incorporation in a quantity of 16.7-27.3%.
33076225	1	10	theme	potential	276:284	arg1	material					303:310	a potential active packaging material	274:310	a potential active packaging material	274:310	In the present study, supercritical solvent impregnation (SSI) has been applied to incorporate thymol into bio-composite polymers as a potential active packaging material.
33076225	9	11	theme	SCZ	1233:1235	arg1	films					1237:1241	SCZ films	1233:1241	SCZ films with thymol loading of approximately 24%	1233:1282	SCZ films with thymol loading of approximately 24% exhibited strong antibacterial activity against E. coli and methicillin-resistant Staphylococcus (S.) aureus (MRSA).
33076225	7	12	theme	vapor	1039:1043	arg1	properties					1018:1027	Mechanical properties	1007:1027	Mechanical properties	1007:1027	Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well.
33076225	7	12	theme	vapor	1039:1043	arg1	permeability					1045:1056	water vapor permeability	1033:1056	water vapor permeability	1033:1056	Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well.
33076225	7	12	theme	vapor	1039:1043	arg1	well					1116:1119	well	1116:1119	well	1116:1119	Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well.
33076225	1	13	theme	active	286:291	arg1	material					303:310	a potential active packaging material	274:310	a potential active packaging material	274:310	In the present study, supercritical solvent impregnation (SSI) has been applied to incorporate thymol into bio-composite polymers as a potential active packaging material.
33076225	4	14	theme	SC	682:683	arg1	films					685:689	SC films	682:689	SC films with starch to chitosan mass ratios of 1:1 and 1:2	682:740	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively.
33076225	6	15	theme	films	1000:1004	arg1	characterization					976:991	the characterization	972:991	the characterization of the films	972:1004	FTIR and SEM analyses were applied for the characterization of the films.
33076225	8	16	from	kinetics	1137:1144	arg1	water					1159:1163	deionized water	1149:1163	deionized water	1149:1163	Thymol release kinetics in deionized water was followed and modeled by the Korsmeyer-Peppas and Weibull model.
33076225	8	17	theme	Weibull	1218:1224	arg1	model					1226:1230	the Korsmeyer-Peppas and Weibull model	1193:1230	the Korsmeyer-Peppas and Weibull model	1193:1230	Thymol release kinetics in deionized water was followed and modeled by the Korsmeyer-Peppas and Weibull model.
33076225	4	18	theme	1:1	730:732	arg1	ratios					720:725	chitosan mass ratios	706:725	chitosan mass ratios of 1:1 and 1:2	706:740	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively.
33076225	2	19	theme	starch-chitosan	413:427	arg1	films					468:472	starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films	413:472	starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent	413:528	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	9	20	theme	thymol	1248:1253	arg1	loading					1255:1261	thymol loading	1248:1261	thymol loading	1248:1261	SCZ films with thymol loading of approximately 24% exhibited strong antibacterial activity against E. coli and methicillin-resistant Staphylococcus (S.) aureus (MRSA).
33076225	5	21	theme	zeolite	803:809	arg1	addition					783:790	The addition	779:790	The addition of natural zeolite (15-60%)	779:818	The addition of natural zeolite (15-60%) significantly increased the loading capacity of films enabling thymol incorporation in a quantity of 16.7-27.3%.
33076225	1	22	theme	packaging	293:301	arg1	material					303:310	a potential active packaging material	274:310	a potential active packaging material	274:310	In the present study, supercritical solvent impregnation (SSI) has been applied to incorporate thymol into bio-composite polymers as a potential active packaging material.
33076225	7	23	theme	Mechanical	1007:1016	arg1	properties					1018:1027	Mechanical properties	1007:1027	Mechanical properties	1007:1027	Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well.
33076225	7	23	theme	Mechanical	1007:1016	arg1	permeability					1045:1056	water vapor permeability	1033:1056	water vapor permeability	1033:1056	Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well.
33076225	7	23	theme	Mechanical	1007:1016	arg1	well					1116:1119	well	1116:1119	well	1116:1119	Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well.
33076225	2	24	theme	natural	323:329	arg1	Thymol					313:318	Thymol	313:318	Thymol	313:318	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	2	24	theme	natural	323:329	arg1	component					331:339	a natural component	321:339	a natural component with a proven antimicrobial activity	321:376	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	9	25	dep	coli	1335:1338	arg1	aureus					1386:1391	aureus	1386:1391	aureus (MRSA)	1386:1398	SCZ films with thymol loading of approximately 24% exhibited strong antibacterial activity against E. coli and methicillin-resistant Staphylococcus (S.) aureus (MRSA).
33076225	9	25	dep	coli	1335:1338	arg1	MRSA					1394:1397	MRSA	1394:1397	MRSA	1394:1397	SCZ films with thymol loading of approximately 24% exhibited strong antibacterial activity against E. coli and methicillin-resistant Staphylococcus (S.) aureus (MRSA).
33076225	0	26	theme	Solvent	29:35	arg1	Impregnation					37:48	Supercritical Solvent Impregnation	15:48	Supercritical Solvent Impregnation	15:48	Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties.
33076225	2	27	with	component	331:339	arg1	activity					369:376	a proven antimicrobial activity	346:376	a proven antimicrobial activity	346:376	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	8	28	theme	Thymol	1122:1127	arg1	kinetics					1137:1144	Thymol release kinetics	1122:1144	Thymol release kinetics in deionized water	1122:1163	Thymol release kinetics in deionized water was followed and modeled by the Korsmeyer-Peppas and Weibull model.
33076225	4	29	theme	mass	715:718	arg1	ratios					720:725	chitosan mass ratios	706:725	chitosan mass ratios of 1:1 and 1:2	706:740	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively.
33076225	2	30	theme	starch-chitosan-zeolite	438:460	arg1	films					468:472	starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films	413:472	starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent	413:528	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	0	31	theme	Supercritical	15:27	arg1	Impregnation					37:48	Supercritical Solvent Impregnation	15:48	Supercritical Solvent Impregnation	15:48	Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties.
33076225	5	32	theme	films	868:872	arg1	capacity					856:863	the loading capacity	844:863	the loading capacity of films enabling thymol incorporation in a quantity of 16.7-27.3%	844:930	The addition of natural zeolite (15-60%) significantly increased the loading capacity of films enabling thymol incorporation in a quantity of 16.7-27.3%.
33076225	4	33	theme	chitosan	706:713	arg1	ratios					720:725	chitosan mass ratios	706:725	chitosan mass ratios of 1:1 and 1:2	706:740	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively.
33076225	8	34	theme	Korsmeyer-Peppas	1197:1212	arg1	model					1226:1230	the Korsmeyer-Peppas and Weibull model	1193:1230	the Korsmeyer-Peppas and Weibull model	1193:1230	Thymol release kinetics in deionized water was followed and modeled by the Korsmeyer-Peppas and Weibull model.
33076225	7	35	theme	films	1061:1065	arg1	properties					1018:1027	Mechanical properties	1007:1027	Mechanical properties	1007:1027	Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well.
33076225	7	35	theme	films	1061:1065	arg1	permeability					1045:1056	water vapor permeability	1033:1056	water vapor permeability	1033:1056	Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well.
33076225	7	35	theme	films	1061:1065	arg1	well					1116:1119	well	1116:1119	well	1116:1119	Mechanical properties and water vapor permeability of films before and after the impregnation were tested as well.
33076225	0	36	theme	Impregnation	37:48	arg1	Application					0:10	Application	0:10	Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties.	0:139	Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties.
33076225	9	37	theme	%	1282:1282	arg1	films					1237:1241	SCZ films	1233:1241	SCZ films with thymol loading of approximately 24%	1233:1282	SCZ films with thymol loading of approximately 24% exhibited strong antibacterial activity against E. coli and methicillin-resistant Staphylococcus (S.) aureus (MRSA).
33076225	2	38	theme	carbon	494:499	arg1	solvent					522:528	a solvent	520:528	a solvent	520:528	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	2	38	theme	carbon	494:499	arg1	scCO2					510:514	scCO2	510:514	scCO2	510:514	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	2	38	theme	carbon	494:499	arg1	dioxide					501:507	supercritical carbon dioxide	480:507	supercritical carbon dioxide (scCO2)	480:515	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	3	39	theme	MPa	593:595	arg1	time					618:621	an impregnation time	602:621	an impregnation time	602:621	Experiments were performed at 35 °C, pressures of 15.5 and 30 MPa, and an impregnation time in the range of 4-24 h.
33076225	3	39	theme	MPa	593:595	arg1	pressures					568:576	pressures	568:576	pressures of 15.5 and 30 MPa	568:595	Experiments were performed at 35 °C, pressures of 15.5 and 30 MPa, and an impregnation time in the range of 4-24 h.
33076225	3	39	theme	MPa	593:595	arg1	°C					564:565	35 °C	561:565	35 °C	561:565	Experiments were performed at 35 °C, pressures of 15.5 and 30 MPa, and an impregnation time in the range of 4-24 h.
33076225	2	40	theme	supercritical	480:492	arg1	solvent					522:528	a solvent	520:528	a solvent	520:528	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	2	40	theme	supercritical	480:492	arg1	scCO2					510:514	scCO2	510:514	scCO2	510:514	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	2	40	theme	supercritical	480:492	arg1	dioxide					501:507	supercritical carbon dioxide	480:507	supercritical carbon dioxide (scCO2)	480:515	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	8	41	theme	release	1129:1135	arg1	kinetics					1137:1144	Thymol release kinetics	1122:1144	Thymol release kinetics in deionized water	1122:1163	Thymol release kinetics in deionized water was followed and modeled by the Korsmeyer-Peppas and Weibull model.
33076225	2	42	theme	antimicrobial	355:367	arg1	activity					369:376	a proven antimicrobial activity	346:376	a proven antimicrobial activity	346:376	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	9	43	theme	strong	1294:1299	arg1	activity					1315:1322	strong antibacterial activity	1294:1322	strong antibacterial activity against E. coli and methicillin-resistant Staphylococcus (S.) aureus (MRSA)	1294:1398	SCZ films with thymol loading of approximately 24% exhibited strong antibacterial activity against E. coli and methicillin-resistant Staphylococcus (S.) aureus (MRSA).
33076225	3	44	theme	h	644:644	arg1	range					630:634	the range	626:634	the range of 4-24 h	626:644	Experiments were performed at 35 °C, pressures of 15.5 and 30 MPa, and an impregnation time in the range of 4-24 h.
33076225	2	45	theme	proven	348:353	arg1	activity					369:376	a proven antimicrobial activity	346:376	a proven antimicrobial activity	346:376	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	9	46	theme	antibacterial	1301:1313	arg1	activity					1315:1322	strong antibacterial activity	1294:1322	strong antibacterial activity against E. coli and methicillin-resistant Staphylococcus (S.) aureus (MRSA)	1294:1398	SCZ films with thymol loading of approximately 24% exhibited strong antibacterial activity against E. coli and methicillin-resistant Staphylococcus (S.) aureus (MRSA).
33076225	6	47	theme	SEM	942:944	arg1	analyses					946:953	FTIR and SEM analyses	933:953	FTIR and SEM analyses	933:953	FTIR and SEM analyses were applied for the characterization of the films.
33076225	1	48	theme	present	148:154	arg1	study					156:160	the present study	144:160	the present study	144:160	In the present study, supercritical solvent impregnation (SSI) has been applied to incorporate thymol into bio-composite polymers as a potential active packaging material.
33076225	3	49	theme	impregnation	605:616	arg1	time					618:621	an impregnation time	602:621	an impregnation time	602:621	Experiments were performed at 35 °C, pressures of 15.5 and 30 MPa, and an impregnation time in the range of 4-24 h.
33076225	4	50	theme	films	685:689	arg1	yields					672:677	The highest impregnation yields	647:677	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2	647:740	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively.
33076225	4	50	theme	films	685:689	arg1	%					752:752	10.80%	747:752	10.80%	747:752	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively.
33076225	8	51	theme	deionized	1149:1157	arg1	water					1159:1163	deionized water	1149:1163	deionized water	1149:1163	Thymol release kinetics in deionized water was followed and modeled by the Korsmeyer-Peppas and Weibull model.
33076225	5	52	theme	loading	848:854	arg1	capacity					856:863	the loading capacity	844:863	the loading capacity of films enabling thymol incorporation in a quantity of 16.7-27.3%	844:930	The addition of natural zeolite (15-60%) significantly increased the loading capacity of films enabling thymol incorporation in a quantity of 16.7-27.3%.
33076225	0	53	theme	Modified	76:83	arg1	Polymers					101:108	Zeolite Modified Starch-Chitosan Polymers	68:108	Zeolite Modified Starch-Chitosan Polymers	68:108	Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties.
33076225	5	54	theme	%	930:930	arg1	quantity					909:916	a quantity	907:916	a quantity of 16.7-27.3%	907:930	The addition of natural zeolite (15-60%) significantly increased the loading capacity of films enabling thymol incorporation in a quantity of 16.7-27.3%.
33076225	0	55	with	Production	54:63	arg1	Properties					129:138	Antibacterial Properties	115:138	Antibacterial Properties	115:138	Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties.
33076225	4	56	theme	highest	651:657	arg1	yields					672:677	The highest impregnation yields	647:677	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2	647:740	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively.
33076225	4	56	theme	highest	651:657	arg1	%					752:752	10.80%	747:752	10.80%	747:752	The highest impregnation yields of SC films with starch to chitosan mass ratios of 1:1 and 1:2 were 10.80% and 6.48%, respectively.
33076225	9	57	with	films	1237:1241	arg1	loading					1255:1261	thymol loading	1248:1261	thymol loading	1248:1261	SCZ films with thymol loading of approximately 24% exhibited strong antibacterial activity against E. coli and methicillin-resistant Staphylococcus (S.) aureus (MRSA).
33076225	1	58	theme	bio-composite	248:260	arg1	polymers					262:269	bio-composite polymers	248:269	bio-composite polymers as a potential active packaging material	248:310	In the present study, supercritical solvent impregnation (SSI) has been applied to incorporate thymol into bio-composite polymers as a potential active packaging material.
33076225	0	59	theme	Zeolite	68:74	arg1	Polymers					101:108	Zeolite Modified Starch-Chitosan Polymers	68:108	Zeolite Modified Starch-Chitosan Polymers	68:108	Application of Supercritical Solvent Impregnation for Production of Zeolite Modified Starch-Chitosan Polymers with Antibacterial Properties.
33076225	2	60	dep	starch-chitosan	413:427	arg1	SCZ					463:465	SCZ	463:465	SCZ	463:465	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	2	60	dep	starch-chitosan	413:427	arg1	SC					430:431	SC	430:431	SC	430:431	Thymol, a natural component with a proven antimicrobial activity, was successfully impregnated into starch-chitosan (SC) and starch-chitosan-zeolite (SCZ) films using supercritical carbon dioxide (scCO2) as a solvent.
33076225	1	61	theme	supercritical	163:175	arg1	SSI					199:201	SSI	199:201	SSI	199:201	In the present study, supercritical solvent impregnation (SSI) has been applied to incorporate thymol into bio-composite polymers as a potential active packaging material.
33076225	1	61	theme	supercritical	163:175	arg1	impregnation					185:196	supercritical solvent impregnation	163:196	supercritical solvent impregnation (SSI)	163:202	In the present study, supercritical solvent impregnation (SSI) has been applied to incorporate thymol into bio-composite polymers as a potential active packaging material.
33076225	6	62	theme	FTIR	933:936	arg1	analyses					946:953	FTIR and SEM analyses	933:953	FTIR and SEM analyses	933:953	FTIR and SEM analyses were applied for the characterization of the films.
32532385	5	0	theme	surface	704:710	arg1	morphology					712:721	denser surface morphology	697:721	denser surface morphology	697:721	Scanning electron microscopy (SEM) indicated CASA showed denser surface morphology than CA.
32532385	4	1	dep	Fourier	476:482	arg1	transform					484:492	transform	484:492	transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR) and elemental analysis	484:591	Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR) and elemental analysis were used to determine the chemical structure.
32532385	1	2	theme	different	136:144	arg1	degree					146:151	different degree	136:151	different degree of substitution (DS) of 2.17∼1.75	136:185	In this paper, cellulose acetate (CA) with different degree of substitution (DS) of 2.17∼1.75 were obtained through hydrolysis of cellulose diacetate (CDA).
32532385	1	3	theme	cellulose	223:231	arg1	diacetate					233:241	cellulose diacetate	223:241	cellulose diacetate (CDA)	223:247	In this paper, cellulose acetate (CA) with different degree of substitution (DS) of 2.17∼1.75 were obtained through hydrolysis of cellulose diacetate (CDA).
32532385	1	3	theme	cellulose	223:231	arg1	CDA					244:246	CDA	244:246	CDA	244:246	In this paper, cellulose acetate (CA) with different degree of substitution (DS) of 2.17∼1.75 were obtained through hydrolysis of cellulose diacetate (CDA).
32532385	7	4	theme	maximum	914:920	arg1	rate					944:947	the maximum relative bactericidal rate	910:947	the maximum relative bactericidal rate	910:947	Specifically, all CASA showed excellent antibacterial ability, the maximum relative bactericidal rate reached 81.5 % for Escherichia coli (E. coli) and 95.4 % for Staphylococcus aureus (S. aureus), respectively.
32532385	3	5	theme	reaction	445:452	arg1	time					454:457	reaction time	445:457	reaction time	445:457	The DS of sorbyl groups varied within 0.12-1.20 by adjusting composition ratio, reaction time and temperature.
32532385	1	6	theme	diacetate	233:241	arg1	hydrolysis					209:218	hydrolysis	209:218	hydrolysis of cellulose diacetate (CDA)	209:247	In this paper, cellulose acetate (CA) with different degree of substitution (DS) of 2.17∼1.75 were obtained through hydrolysis of cellulose diacetate (CDA).
32532385	8	7	theme	CASA	1082:1085	arg1	films					1087:1091	the obtained CASA films	1069:1091	the obtained CASA films using casting technique	1069:1115	Moreover, the obtained CASA films using casting technique possessed good mechanical properties.
32532385	7	8	theme	relative	922:929	arg1	rate					944:947	the maximum relative bactericidal rate	910:947	the maximum relative bactericidal rate	910:947	Specifically, all CASA showed excellent antibacterial ability, the maximum relative bactericidal rate reached 81.5 % for Escherichia coli (E. coli) and 95.4 % for Staphylococcus aureus (S. aureus), respectively.
32532385	4	9	theme	magnetic	532:539	arg1	resonance					541:549	Nuclear magnetic resonance	524:549	Nuclear magnetic resonance spectroscopy (NMR)	524:568	Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR) and elemental analysis were used to determine the chemical structure.
32532385	8	10	theme	obtained	1073:1080	arg1	films					1087:1091	the obtained CASA films	1069:1091	the obtained CASA films using casting technique	1069:1115	Moreover, the obtained CASA films using casting technique possessed good mechanical properties.
32532385	9	11	from	application	1200:1210	arg1	fields					1226:1231	healthcare fields	1215:1231	healthcare fields	1215:1231	These antibacterial CASA exhibited potential application in healthcare fields.
32532385	4	12	theme	Nuclear	524:530	arg1	resonance					541:549	Nuclear magnetic resonance	524:549	Nuclear magnetic resonance spectroscopy (NMR)	524:568	Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR) and elemental analysis were used to determine the chemical structure.
32532385	3	13	theme	composition	426:436	arg1	ratio					438:442	composition ratio	426:442	composition ratio	426:442	The DS of sorbyl groups varied within 0.12-1.20 by adjusting composition ratio, reaction time and temperature.
32532385	2	14	theme	acid	354:357	arg1	esterification					322:335	esterification	322:335	esterification of CA and sorbic acid (SA)	322:362	Furthermore, novel cellulose acetate sorbate (CASA) were synthesized by esterification of CA and sorbic acid (SA).
32532385	6	15	theme	service	827:833	arg1	performance					835:845	their service performance	821:845	their service performance	821:845	Thermal properties and crystallization of CASA were slightly decrease but did not affect their service performance.
32532385	6	16	theme	Thermal	732:738	arg1	properties					740:749	Thermal properties	732:749	Thermal properties	732:749	Thermal properties and crystallization of CASA were slightly decrease but did not affect their service performance.
32532385	4	17	theme	resonance	541:549	arg1	spectroscopy					551:562	Nuclear magnetic resonance spectroscopy	524:562	Nuclear magnetic resonance spectroscopy (NMR)	524:568	Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR) and elemental analysis were used to determine the chemical structure.
32532385	4	17	theme	resonance	541:549	arg1	NMR					565:567	NMR	565:567	NMR	565:567	Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR) and elemental analysis were used to determine the chemical structure.
32532385	2	18	theme	sorbic	347:352	arg1	SA					360:361	SA	360:361	SA	360:361	Furthermore, novel cellulose acetate sorbate (CASA) were synthesized by esterification of CA and sorbic acid (SA).
32532385	2	18	theme	sorbic	347:352	arg1	acid					354:357	sorbic acid	347:357	sorbic acid (SA)	347:362	Furthermore, novel cellulose acetate sorbate (CASA) were synthesized by esterification of CA and sorbic acid (SA).
32532385	7	19	dep	coli	980:983	arg1	coli					989:992	E. coli	986:992	E. coli	986:992	Specifically, all CASA showed excellent antibacterial ability, the maximum relative bactericidal rate reached 81.5 % for Escherichia coli (E. coli) and 95.4 % for Staphylococcus aureus (S. aureus), respectively.
32532385	8	20	theme	casting	1099:1105	arg1	technique					1107:1115	casting technique	1099:1115	casting technique	1099:1115	Moreover, the obtained CASA films using casting technique possessed good mechanical properties.
32532385	1	21	with	acetate	118:124	arg1	degree					146:151	different degree	136:151	different degree of substitution (DS) of 2.17∼1.75	136:185	In this paper, cellulose acetate (CA) with different degree of substitution (DS) of 2.17∼1.75 were obtained through hydrolysis of cellulose diacetate (CDA).
32532385	2	22	theme	acetate	279:285	arg1	CASA					296:299	CASA	296:299	CASA	296:299	Furthermore, novel cellulose acetate sorbate (CASA) were synthesized by esterification of CA and sorbic acid (SA).
32532385	2	22	theme	acetate	279:285	arg1	sorbate					287:293	novel cellulose acetate sorbate	263:293	novel cellulose acetate sorbate (CASA)	263:300	Furthermore, novel cellulose acetate sorbate (CASA) were synthesized by esterification of CA and sorbic acid (SA).
32532385	2	23	theme	CA	340:341	arg1	esterification					322:335	esterification	322:335	esterification of CA and sorbic acid (SA)	322:362	Furthermore, novel cellulose acetate sorbate (CASA) were synthesized by esterification of CA and sorbic acid (SA).
32532385	8	24	theme	good	1127:1130	arg1	properties					1143:1152	good mechanical properties	1127:1152	good mechanical properties	1127:1152	Moreover, the obtained CASA films using casting technique possessed good mechanical properties.
32532385	4	25	theme	infrared	494:501	arg1	spectroscopy					503:514	infrared spectroscopy	494:514	infrared spectroscopy (FTIR)	494:521	Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR) and elemental analysis were used to determine the chemical structure.
32532385	4	25	theme	infrared	494:501	arg1	FTIR					517:520	FTIR	517:520	FTIR	517:520	Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR) and elemental analysis were used to determine the chemical structure.
32532385	5	26	theme	Scanning	640:647	arg1	SEM					670:672	SEM	670:672	SEM	670:672	Scanning electron microscopy (SEM) indicated CASA showed denser surface morphology than CA.
32532385	5	26	theme	Scanning	640:647	arg1	microscopy					658:667	Scanning electron microscopy	640:667	Scanning electron microscopy (SEM)	640:673	Scanning electron microscopy (SEM) indicated CASA showed denser surface morphology than CA.
32532385	7	27	theme	excellent	877:885	arg1	ability					901:907	excellent antibacterial ability	877:907	excellent antibacterial ability	877:907	Specifically, all CASA showed excellent antibacterial ability, the maximum relative bactericidal rate reached 81.5 % for Escherichia coli (E. coli) and 95.4 % for Staphylococcus aureus (S. aureus), respectively.
32532385	2	28	theme	cellulose	269:277	arg1	CASA					296:299	CASA	296:299	CASA	296:299	Furthermore, novel cellulose acetate sorbate (CASA) were synthesized by esterification of CA and sorbic acid (SA).
32532385	2	28	theme	cellulose	269:277	arg1	sorbate					287:293	novel cellulose acetate sorbate	263:293	novel cellulose acetate sorbate (CASA)	263:300	Furthermore, novel cellulose acetate sorbate (CASA) were synthesized by esterification of CA and sorbic acid (SA).
32532385	5	29	theme	electron	649:656	arg1	SEM					670:672	SEM	670:672	SEM	670:672	Scanning electron microscopy (SEM) indicated CASA showed denser surface morphology than CA.
32532385	5	29	theme	electron	649:656	arg1	microscopy					658:667	Scanning electron microscopy	640:667	Scanning electron microscopy (SEM)	640:673	Scanning electron microscopy (SEM) indicated CASA showed denser surface morphology than CA.
32532385	9	30	theme	potential	1190:1198	arg1	application					1200:1210	potential application	1190:1210	potential application in healthcare fields	1190:1231	These antibacterial CASA exhibited potential application in healthcare fields.
32532385	2	31	theme	novel	263:267	arg1	CASA					296:299	CASA	296:299	CASA	296:299	Furthermore, novel cellulose acetate sorbate (CASA) were synthesized by esterification of CA and sorbic acid (SA).
32532385	2	31	theme	novel	263:267	arg1	sorbate					287:293	novel cellulose acetate sorbate	263:293	novel cellulose acetate sorbate (CASA)	263:300	Furthermore, novel cellulose acetate sorbate (CASA) were synthesized by esterification of CA and sorbic acid (SA).
32532385	3	32	theme	groups	382:387	arg1	DS					369:370	The DS	365:370	The DS of sorbyl groups	365:387	The DS of sorbyl groups varied within 0.12-1.20 by adjusting composition ratio, reaction time and temperature.
32532385	1	33	theme	2.17∼1.75	177:185	arg1	DS					170:171	DS	170:171	DS	170:171	In this paper, cellulose acetate (CA) with different degree of substitution (DS) of 2.17∼1.75 were obtained through hydrolysis of cellulose diacetate (CDA).
32532385	1	33	theme	2.17∼1.75	177:185	arg1	substitution					156:167	substitution	156:167	substitution (DS) of 2.17∼1.75	156:185	In this paper, cellulose acetate (CA) with different degree of substitution (DS) of 2.17∼1.75 were obtained through hydrolysis of cellulose diacetate (CDA).
32532385	0	34	theme	antibacterial	32:44	arg1	properties					46:55	antibacterial properties	32:55	antibacterial properties	32:55	Synthesis, characterization and antibacterial properties of novel cellulose acetate sorbate.
32532385	7	35	dep	aureus	1025:1030	arg1	aureus					1036:1041	S. aureus	1033:1041	S. aureus	1033:1041	Specifically, all CASA showed excellent antibacterial ability, the maximum relative bactericidal rate reached 81.5 % for Escherichia coli (E. coli) and 95.4 % for Staphylococcus aureus (S. aureus), respectively.
32532385	4	36	theme	elemental	574:582	arg1	analysis					584:591	elemental analysis	574:591	elemental analysis	574:591	Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR) and elemental analysis were used to determine the chemical structure.
32532385	0	37	theme	novel	60:64	arg1	acetate					76:82	novel cellulose acetate	60:82	novel cellulose acetate	60:82	Synthesis, characterization and antibacterial properties of novel cellulose acetate sorbate.
32532385	8	38	theme	mechanical	1132:1141	arg1	properties					1143:1152	good mechanical properties	1127:1152	good mechanical properties	1127:1152	Moreover, the obtained CASA films using casting technique possessed good mechanical properties.
32532385	5	39	theme	denser	697:702	arg1	morphology					712:721	denser surface morphology	697:721	denser surface morphology	697:721	Scanning electron microscopy (SEM) indicated CASA showed denser surface morphology than CA.
32532385	1	40	theme	cellulose	108:116	arg1	CA					127:128	CA	127:128	CA	127:128	In this paper, cellulose acetate (CA) with different degree of substitution (DS) of 2.17∼1.75 were obtained through hydrolysis of cellulose diacetate (CDA).
32532385	1	40	theme	cellulose	108:116	arg1	acetate					118:124	cellulose acetate	108:124	cellulose acetate (CA) with different degree of substitution (DS) of 2.17∼1.75	108:185	In this paper, cellulose acetate (CA) with different degree of substitution (DS) of 2.17∼1.75 were obtained through hydrolysis of cellulose diacetate (CDA).
32532385	7	41	theme	antibacterial	887:899	arg1	ability					901:907	excellent antibacterial ability	877:907	excellent antibacterial ability	877:907	Specifically, all CASA showed excellent antibacterial ability, the maximum relative bactericidal rate reached 81.5 % for Escherichia coli (E. coli) and 95.4 % for Staphylococcus aureus (S. aureus), respectively.
32532385	8	42	contain	possessed	1117:1125	arg2	properties					1143:1152	good mechanical properties	1127:1152	good mechanical properties	1127:1152	Moreover, the obtained CASA films using casting technique possessed good mechanical properties.
32532385	8	42	contain	possessed	1117:1125	arg1	films					1087:1091	the obtained CASA films	1069:1091	the obtained CASA films using casting technique	1069:1115	Moreover, the obtained CASA films using casting technique possessed good mechanical properties.
32532385	4	43	used	used	598:601	arg2	Fourier					476:482	Fourier	476:482	Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR) and elemental analysis	476:591	Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR) and elemental analysis were used to determine the chemical structure.
32532385	9	44	theme	healthcare	1215:1224	arg1	fields					1226:1231	healthcare fields	1215:1231	healthcare fields	1215:1231	These antibacterial CASA exhibited potential application in healthcare fields.
32532385	3	45	theme	sorbyl	375:380	arg1	groups					382:387	sorbyl groups	375:387	sorbyl groups	375:387	The DS of sorbyl groups varied within 0.12-1.20 by adjusting composition ratio, reaction time and temperature.
32532385	0	46	theme	acetate	76:82	arg1	characterization					11:26	characterization	11:26	characterization	11:26	Synthesis, characterization and antibacterial properties of novel cellulose acetate sorbate.
32532385	0	46	theme	acetate	76:82	arg1	properties					46:55	antibacterial properties	32:55	antibacterial properties	32:55	Synthesis, characterization and antibacterial properties of novel cellulose acetate sorbate.
32532385	0	46	theme	acetate	76:82	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis, characterization and antibacterial properties of novel cellulose acetate sorbate.
32532385	6	47	theme	CASA	774:777	arg1	crystallization					755:769	crystallization	755:769	crystallization of CASA	755:777	Thermal properties and crystallization of CASA were slightly decrease but did not affect their service performance.
32532385	6	47	theme	CASA	774:777	arg1	properties					740:749	Thermal properties	732:749	Thermal properties	732:749	Thermal properties and crystallization of CASA were slightly decrease but did not affect their service performance.
32532385	9	48	theme	antibacterial	1161:1173	arg1	CASA					1175:1178	These antibacterial CASA	1155:1178	These antibacterial CASA	1155:1178	These antibacterial CASA exhibited potential application in healthcare fields.
32532385	4	49	theme	chemical	620:627	arg1	structure					629:637	the chemical structure	616:637	the chemical structure	616:637	Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance spectroscopy (NMR) and elemental analysis were used to determine the chemical structure.
32532385	1	50	theme	substitution	156:167	arg1	degree					146:151	different degree	136:151	different degree of substitution (DS) of 2.17∼1.75	136:185	In this paper, cellulose acetate (CA) with different degree of substitution (DS) of 2.17∼1.75 were obtained through hydrolysis of cellulose diacetate (CDA).
32532385	0	51	theme	cellulose	66:74	arg1	acetate					76:82	novel cellulose acetate	60:82	novel cellulose acetate	60:82	Synthesis, characterization and antibacterial properties of novel cellulose acetate sorbate.
32532385	7	52	theme	bactericidal	931:942	arg1	rate					944:947	the maximum relative bactericidal rate	910:947	the maximum relative bactericidal rate	910:947	Specifically, all CASA showed excellent antibacterial ability, the maximum relative bactericidal rate reached 81.5 % for Escherichia coli (E. coli) and 95.4 % for Staphylococcus aureus (S. aureus), respectively.
32532385	7	53	dep	showed	870:875	arg1	reached					949:955	reached	949:955	reached 81.5 % for Escherichia coli (E. coli) and 95.4 % for Staphylococcus aureus (S. aureus), respectively	949:1056	Specifically, all CASA showed excellent antibacterial ability, the maximum relative bactericidal rate reached 81.5 % for Escherichia coli (E. coli) and 95.4 % for Staphylococcus aureus (S. aureus), respectively.
34946764	7	0	with	data	1325:1328	arg1	filler					1345:1350	5 and 10% filler	1335:1350	5 and 10% filler	1335:1350	Tensile performance of the composites indicates some reduction with respect to the pure polymer in terms of tensile strength, though stabilizing between data with 5 and 10% filler.
34946764	3	1	theme	polymerization	617:630	arg1	process					632:638	the polymerization process	613:638	the polymerization process	613:638	FTIR analysis of final PUA synthesized used for the composite production confirmed the new bonds formed during the polymerization process.
34946764	1	2	theme	poly	129:132	arg1	polymer					153:159	A poly(urethane-acrylate) polymer	127:159	A poly(urethane-acrylate) polymer (PUA)	127:165	A poly(urethane-acrylate) polymer (PUA) was synthesized, and a sufficiently high molecular weight starting from urethane-acrylate oligomer (UAO) was obtained.
34946764	1	2	theme	poly	129:132	arg1	PUA					162:164	PUA	162:164	PUA	162:164	A poly(urethane-acrylate) polymer (PUA) was synthesized, and a sufficiently high molecular weight starting from urethane-acrylate oligomer (UAO) was obtained.
34946764	4	3	theme	waste	690:694	arg1	types					681:685	the two types	673:685	the two types of waste used	673:699	The degradation temperatures of the two types of waste used were in line with what observed in most common natural fibers with an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one.
34946764	1	4	theme	high	203:206	arg1	weight					218:223	a sufficiently high molecular weight	188:223	a sufficiently high molecular weight starting from urethane-acrylate oligomer (UAO)	188:270	A poly(urethane-acrylate) polymer (PUA) was synthesized, and a sufficiently high molecular weight starting from urethane-acrylate oligomer (UAO) was obtained.
34946764	0	5	theme	Waste	72:76	arg1	Characterization					24:39	Chemical and Mechanical Characterization	0:39	Chemical and Mechanical Characterization of Licorice Root and Palm Leaf Waste	0:76	Chemical and Mechanical Characterization of Licorice Root and Palm Leaf Waste Incorporated into Poly(urethane-acrylate) (PUA).
34946764	6	6	theme	waste	1066:1070	arg1	addition					1072:1079	palm leaf waste addition	1056:1079	palm leaf waste addition	1056:1079	In the composites, only a limited reduction of degradation temperature was observed for palm leaf waste addition and some dispersion issues are observed for licorice root, leading to fluctuating results.
34946764	8	7	dep	increase	1541:1548	arg1	%					1558:1558	%	1558:1558	%	1558:1558	In contrast, Shore A hardness of both composites slightly increases with higher filler content, while in stiffness-driven applications licorice-based composites showed potential due to an increase up to 50% compared to neat PUA.
34946764	1	8	theme	molecular	208:216	arg1	weight					218:223	a sufficiently high molecular weight	188:223	a sufficiently high molecular weight starting from urethane-acrylate oligomer (UAO)	188:270	A poly(urethane-acrylate) polymer (PUA) was synthesized, and a sufficiently high molecular weight starting from urethane-acrylate oligomer (UAO) was obtained.
34946764	9	9	with	rougher	1637:1643	arg1	introduction					1657:1668	filler introduction	1650:1668	filler introduction	1650:1668	In general terms, the fracture surfaces tend to become rougher with filler introduction, which indicates the need for optimizing interfacial adhesion.
34946764	6	10	theme	leaf	1061:1064	arg1	addition					1072:1079	palm leaf waste addition	1056:1079	palm leaf waste addition	1056:1079	In the composites, only a limited reduction of degradation temperature was observed for palm leaf waste addition and some dispersion issues are observed for licorice root, leading to fluctuating results.
34946764	8	11	theme	neat	1572:1575	arg1	PUA					1577:1579	neat PUA	1572:1579	neat PUA	1572:1579	In contrast, Shore A hardness of both composites slightly increases with higher filler content, while in stiffness-driven applications licorice-based composites showed potential due to an increase up to 50% compared to neat PUA.
34946764	9	12	theme	filler	1650:1655	arg1	introduction					1657:1668	filler introduction	1650:1668	filler introduction	1650:1668	In general terms, the fracture surfaces tend to become rougher with filler introduction, which indicates the need for optimizing interfacial adhesion.
34946764	6	13	theme	palm	1056:1059	arg1	addition					1072:1079	palm leaf waste addition	1056:1079	palm leaf waste addition	1056:1079	In the composites, only a limited reduction of degradation temperature was observed for palm leaf waste addition and some dispersion issues are observed for licorice root, leading to fluctuating results.
34946764	8	14	theme	composites	1391:1400	arg1	hardness					1374:1381	Shore A hardness	1366:1381	Shore A hardness of both composites	1366:1400	In contrast, Shore A hardness of both composites slightly increases with higher filler content, while in stiffness-driven applications licorice-based composites showed potential due to an increase up to 50% compared to neat PUA.
34946764	4	15	theme	types	681:685	arg1	temperatures					657:668	The degradation temperatures	641:668	The degradation temperatures of the two types of waste used	641:699	The degradation temperatures of the two types of waste used were in line with what observed in most common natural fibers with an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one.
34946764	5	16	from	abundant	860:867	arg1	cellulose					872:880	cellulose	872:880	cellulose	872:880	The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose).
34946764	4	17	from	°C	818:819	arg1	onset					771:775	an onset	768:775	an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one	768:837	The degradation temperatures of the two types of waste used were in line with what observed in most common natural fibers with an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one.
34946764	2	18	theme	%	423:423	arg1	%					423:423	1, 5 and 10%	412:423	1, 5 and 10%	412:423	PUA was then loaded with two types of powdered ligno-cellulosic waste, namely from licorice root and palm leaf, in amounts of 1, 5 and 10%, and the obtained composites were chemically and mechanically characterized.
34946764	2	18	theme	%	423:423	arg1	amounts					401:407	amounts	401:407	amounts of 1, 5 and 10%	401:423	PUA was then loaded with two types of powdered ligno-cellulosic waste, namely from licorice root and palm leaf, in amounts of 1, 5 and 10%, and the obtained composites were chemically and mechanically characterized.
34946764	6	19	located	observed	1043:1050	arg1	composites					975:984	the composites	971:984	the composites	971:984	In the composites, only a limited reduction of degradation temperature was observed for palm leaf waste addition and some dispersion issues are observed for licorice root, leading to fluctuating results.
34946764	6	19	located	observed	1043:1050	arg2	reduction					1002:1010	only a limited reduction	987:1010	only a limited reduction of degradation temperature	987:1037	In the composites, only a limited reduction of degradation temperature was observed for palm leaf waste addition and some dispersion issues are observed for licorice root, leading to fluctuating results.
34946764	4	20	theme	natural	748:754	arg1	fibers					756:761	most common natural fibers	736:761	most common natural fibers with an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one	736:837	The degradation temperatures of the two types of waste used were in line with what observed in most common natural fibers with an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one.
34946764	4	21	with	fibers	756:761	arg1	onset					771:775	an onset	768:775	an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one	768:837	The degradation temperatures of the two types of waste used were in line with what observed in most common natural fibers with an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one.
34946764	8	22	theme	stiffness-driven	1458:1473	arg1	applications					1475:1486	stiffness-driven applications	1458:1486	stiffness-driven applications	1458:1486	In contrast, Shore A hardness of both composites slightly increases with higher filler content, while in stiffness-driven applications licorice-based composites showed potential due to an increase up to 50% compared to neat PUA.
34946764	1	23	theme	urethane-acrylate	134:150	arg1	polymer					153:159	A poly(urethane-acrylate) polymer	127:159	A poly(urethane-acrylate) polymer (PUA)	127:165	A poly(urethane-acrylate) polymer (PUA) was synthesized, and a sufficiently high molecular weight starting from urethane-acrylate oligomer (UAO) was obtained.
34946764	1	23	theme	urethane-acrylate	134:150	arg1	PUA					162:164	PUA	162:164	PUA	162:164	A poly(urethane-acrylate) polymer (PUA) was synthesized, and a sufficiently high molecular weight starting from urethane-acrylate oligomer (UAO) was obtained.
34946764	4	24	theme	palm	825:828	arg1	leaf					830:833	palm leaf one	825:837	palm leaf one	825:837	The degradation temperatures of the two types of waste used were in line with what observed in most common natural fibers with an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one.
34946764	7	25	dep	filler	1345:1350	arg1	%					1343:1343	%	1343:1343	%	1343:1343	Tensile performance of the composites indicates some reduction with respect to the pure polymer in terms of tensile strength, though stabilizing between data with 5 and 10% filler.
34946764	4	26	theme	common	741:746	arg1	fibers					756:761	most common natural fibers	736:761	most common natural fibers with an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one	736:837	The degradation temperatures of the two types of waste used were in line with what observed in most common natural fibers with an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one.
34946764	0	27	theme	Chemical	0:7	arg1	Characterization					24:39	Chemical and Mechanical Characterization	0:39	Chemical and Mechanical Characterization of Licorice Root and Palm Leaf Waste	0:76	Chemical and Mechanical Characterization of Licorice Root and Palm Leaf Waste Incorporated into Poly(urethane-acrylate) (PUA).
34946764	2	28	theme	ligno-cellulosic	333:348	arg1	waste					350:354	powdered ligno-cellulosic waste	324:354	powdered ligno-cellulosic waste	324:354	PUA was then loaded with two types of powdered ligno-cellulosic waste, namely from licorice root and palm leaf, in amounts of 1, 5 and 10%, and the obtained composites were chemically and mechanically characterized.
34946764	6	29	theme	fluctuating	1151:1161	arg1	results					1163:1169	fluctuating results	1151:1169	fluctuating results	1151:1169	In the composites, only a limited reduction of degradation temperature was observed for palm leaf waste addition and some dispersion issues are observed for licorice root, leading to fluctuating results.
34946764	7	30	dep	%	1343:1343	arg1	10					1341:1342	10	1341:1342	10	1341:1342	Tensile performance of the composites indicates some reduction with respect to the pure polymer in terms of tensile strength, though stabilizing between data with 5 and 10% filler.
34946764	7	30	dep	%	1343:1343	arg1	5					1335:1335	5	1335:1335	5	1335:1335	Tensile performance of the composites indicates some reduction with respect to the pure polymer in terms of tensile strength, though stabilizing between data with 5 and 10% filler.
34946764	7	31	theme	pure	1255:1258	arg1	polymer					1260:1266	the pure polymer	1251:1266	the pure polymer	1251:1266	Tensile performance of the composites indicates some reduction with respect to the pure polymer in terms of tensile strength, though stabilizing between data with 5 and 10% filler.
34946764	2	32	theme	powdered	324:331	arg1	waste					350:354	powdered ligno-cellulosic waste	324:354	powdered ligno-cellulosic waste	324:354	PUA was then loaded with two types of powdered ligno-cellulosic waste, namely from licorice root and palm leaf, in amounts of 1, 5 and 10%, and the obtained composites were chemically and mechanically characterized.
34946764	2	33	theme	palm	387:390	arg1	leaf					392:395	palm leaf	387:395	palm leaf	387:395	PUA was then loaded with two types of powdered ligno-cellulosic waste, namely from licorice root and palm leaf, in amounts of 1, 5 and 10%, and the obtained composites were chemically and mechanically characterized.
34946764	6	34	theme	temperature	1027:1037	arg1	reduction					1002:1010	only a limited reduction	987:1010	only a limited reduction of degradation temperature	987:1037	In the composites, only a limited reduction of degradation temperature was observed for palm leaf waste addition and some dispersion issues are observed for licorice root, leading to fluctuating results.
34946764	7	35	theme	composites	1199:1208	arg1	performance					1180:1190	Tensile performance	1172:1190	Tensile performance of the composites	1172:1208	Tensile performance of the composites indicates some reduction with respect to the pure polymer in terms of tensile strength, though stabilizing between data with 5 and 10% filler.
34946764	9	36	theme	general	1585:1591	arg1	terms					1593:1597	general terms	1585:1597	general terms	1585:1597	In general terms, the fracture surfaces tend to become rougher with filler introduction, which indicates the need for optimizing interfacial adhesion.
34946764	8	37	dep	50	1556:1557	arg1	to					1553:1554	to	1553:1554	to	1553:1554	In contrast, Shore A hardness of both composites slightly increases with higher filler content, while in stiffness-driven applications licorice-based composites showed potential due to an increase up to 50% compared to neat PUA.
34946764	8	38	theme	A	1372:1372	arg1	hardness					1374:1381	Shore A hardness	1366:1381	Shore A hardness of both composites	1366:1400	In contrast, Shore A hardness of both composites slightly increases with higher filler content, while in stiffness-driven applications licorice-based composites showed potential due to an increase up to 50% compared to neat PUA.
34946764	1	39	theme	urethane-acrylate	239:255	arg1	oligomer					257:264	urethane-acrylate oligomer	239:264	urethane-acrylate oligomer (UAO)	239:270	A poly(urethane-acrylate) polymer (PUA) was synthesized, and a sufficiently high molecular weight starting from urethane-acrylate oligomer (UAO) was obtained.
34946764	1	39	theme	urethane-acrylate	239:255	arg1	UAO					267:269	UAO	267:269	UAO	267:269	A poly(urethane-acrylate) polymer (PUA) was synthesized, and a sufficiently high molecular weight starting from urethane-acrylate oligomer (UAO) was obtained.
34946764	6	40	theme	licorice	1125:1132	arg1	root					1134:1137	licorice root	1125:1137	licorice root	1125:1137	In the composites, only a limited reduction of degradation temperature was observed for palm leaf waste addition and some dispersion issues are observed for licorice root, leading to fluctuating results.
34946764	6	41	theme	limited	994:1000	arg1	reduction					1002:1010	only a limited reduction	987:1010	only a limited reduction of degradation temperature	987:1037	In the composites, only a limited reduction of degradation temperature was observed for palm leaf waste addition and some dispersion issues are observed for licorice root, leading to fluctuating results.
34946764	8	42	dep	%	1558:1558	arg1	50					1556:1557	50	1556:1557	50	1556:1557	In contrast, Shore A hardness of both composites slightly increases with higher filler content, while in stiffness-driven applications licorice-based composites showed potential due to an increase up to 50% compared to neat PUA.
34946764	2	43	theme	licorice	369:376	arg1	root					378:381	licorice root	369:381	licorice root	369:381	PUA was then loaded with two types of powdered ligno-cellulosic waste, namely from licorice root and palm leaf, in amounts of 1, 5 and 10%, and the obtained composites were chemically and mechanically characterized.
34946764	0	44	theme	Mechanical	13:22	arg1	Characterization					24:39	Chemical and Mechanical Characterization	0:39	Chemical and Mechanical Characterization of Licorice Root and Palm Leaf Waste	0:76	Chemical and Mechanical Characterization of Licorice Root and Palm Leaf Waste Incorporated into Poly(urethane-acrylate) (PUA).
34946764	3	45	theme	composite	554:562	arg1	production					564:573	the composite production	550:573	the composite production	550:573	FTIR analysis of final PUA synthesized used for the composite production confirmed the new bonds formed during the polymerization process.
34946764	5	46	from	cellulose	872:880	arg1	abundant					860:867	abundant	860:867	abundant	860:867	The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose).
34946764	5	46	from	cellulose	872:880	arg1	%					893:893	12%	891:893	12%	891:893	The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose).
34946764	5	46	from	cellulose	872:880	arg1	%					885:885	44%	883:885	44%	883:885	The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose).
34946764	5	46	from	cellulose	872:880	arg1	former					844:849	former	844:849	former	844:849	The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose).
34946764	0	47	theme	Licorice	44:51	arg1	Root					53:56	Licorice Root	44:56	Licorice Root	44:56	Chemical and Mechanical Characterization of Licorice Root and Palm Leaf Waste Incorporated into Poly(urethane-acrylate) (PUA).
34946764	2	48	theme	obtained	434:441	arg1	composites					443:452	the obtained composites	430:452	the obtained composites	430:452	PUA was then loaded with two types of powdered ligno-cellulosic waste, namely from licorice root and palm leaf, in amounts of 1, 5 and 10%, and the obtained composites were chemically and mechanically characterized.
34946764	6	49	theme	degradation	1015:1025	arg1	temperature					1027:1037	degradation temperature	1015:1037	degradation temperature	1015:1037	In the composites, only a limited reduction of degradation temperature was observed for palm leaf waste addition and some dispersion issues are observed for licorice root, leading to fluctuating results.
34946764	8	50	theme	higher	1426:1431	arg1	content					1440:1446	higher filler content	1426:1446	higher filler content	1426:1446	In contrast, Shore A hardness of both composites slightly increases with higher filler content, while in stiffness-driven applications licorice-based composites showed potential due to an increase up to 50% compared to neat PUA.
34946764	2	51	theme	waste	350:354	arg1	types					315:319	two types	311:319	two types of powdered ligno-cellulosic waste	311:354	PUA was then loaded with two types of powdered ligno-cellulosic waste, namely from licorice root and palm leaf, in amounts of 1, 5 and 10%, and the obtained composites were chemically and mechanically characterized.
34946764	5	52	dep	richer	926:931	arg1	%					954:954	26%	952:954	26%	952:954	The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose).
34946764	5	52	dep	richer	926:931	arg1	%					946:946	30%	944:946	30%	944:946	The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose).
34946764	7	53	theme	Tensile	1172:1178	arg1	performance					1180:1190	Tensile performance	1172:1190	Tensile performance of the composites	1172:1208	Tensile performance of the composites indicates some reduction with respect to the pure polymer in terms of tensile strength, though stabilizing between data with 5 and 10% filler.
34946764	9	54	theme	interfacial	1711:1721	arg1	adhesion					1723:1730	interfacial adhesion	1711:1730	interfacial adhesion	1711:1730	In general terms, the fracture surfaces tend to become rougher with filler introduction, which indicates the need for optimizing interfacial adhesion.
34946764	5	55	dep	%	946:946	arg1	cellulose					956:964	cellulose	956:964	cellulose	956:964	The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose).
34946764	0	56	theme	Root	53:56	arg1	Characterization					24:39	Chemical and Mechanical Characterization	0:39	Chemical and Mechanical Characterization of Licorice Root and Palm Leaf Waste	0:76	Chemical and Mechanical Characterization of Licorice Root and Palm Leaf Waste Incorporated into Poly(urethane-acrylate) (PUA).
34946764	6	57	theme	dispersion	1090:1099	arg1	issues					1101:1106	some dispersion issues	1085:1106	some dispersion issues	1085:1106	In the composites, only a limited reduction of degradation temperature was observed for palm leaf waste addition and some dispersion issues are observed for licorice root, leading to fluctuating results.
34946764	3	58	theme	new	589:591	arg1	bonds					593:597	the new bonds	585:597	the new bonds formed during the polymerization process	585:638	FTIR analysis of final PUA synthesized used for the composite production confirmed the new bonds formed during the polymerization process.
34946764	3	59	theme	FTIR	502:505	arg1	analysis					507:514	FTIR analysis	502:514	FTIR analysis of final PUA synthesized used for the composite production	502:573	FTIR analysis of final PUA synthesized used for the composite production confirmed the new bonds formed during the polymerization process.
34946764	8	60	theme	licorice-based	1488:1501	arg1	composites					1503:1512	licorice-based composites	1488:1512	licorice-based composites	1488:1512	In contrast, Shore A hardness of both composites slightly increases with higher filler content, while in stiffness-driven applications licorice-based composites showed potential due to an increase up to 50% compared to neat PUA.
34946764	9	61	theme	fracture	1604:1611	arg1	surfaces					1613:1620	the fracture surfaces	1600:1620	the fracture surfaces	1600:1620	In general terms, the fracture surfaces tend to become rougher with filler introduction, which indicates the need for optimizing interfacial adhesion.
34946764	4	62	theme	degradation	645:655	arg1	temperatures					657:668	The degradation temperatures	641:668	The degradation temperatures of the two types of waste used	641:699	The degradation temperatures of the two types of waste used were in line with what observed in most common natural fibers with an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one.
34946764	8	63	theme	Shore	1366:1370	arg1	hardness					1374:1381	Shore A hardness	1366:1381	Shore A hardness of both composites	1366:1400	In contrast, Shore A hardness of both composites slightly increases with higher filler content, while in stiffness-driven applications licorice-based composites showed potential due to an increase up to 50% compared to neat PUA.
34946764	4	64	theme	licorice	791:798	arg1	waste					800:804	licorice waste	791:804	licorice waste	791:804	The degradation temperatures of the two types of waste used were in line with what observed in most common natural fibers with an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one.
34946764	7	65	theme	tensile	1280:1286	arg1	strength					1288:1295	tensile strength	1280:1295	tensile strength	1280:1295	Tensile performance of the composites indicates some reduction with respect to the pure polymer in terms of tensile strength, though stabilizing between data with 5 and 10% filler.
34946764	8	66	theme	filler	1433:1438	arg1	content					1440:1446	higher filler content	1426:1446	higher filler content	1426:1446	In contrast, Shore A hardness of both composites slightly increases with higher filler content, while in stiffness-driven applications licorice-based composites showed potential due to an increase up to 50% compared to neat PUA.
34946764	0	67	theme	Leaf	67:70	arg1	Waste					72:76	Palm Leaf Waste	62:76	Palm Leaf Waste	62:76	Chemical and Mechanical Characterization of Licorice Root and Palm Leaf Waste Incorporated into Poly(urethane-acrylate) (PUA).
34946764	4	68	from	°C	784:785	arg1	onset					771:775	an onset	768:775	an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one	768:837	The degradation temperatures of the two types of waste used were in line with what observed in most common natural fibers with an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one.
34946764	3	69	theme	final	519:523	arg1	PUA					525:527	final PUA	519:527	final PUA synthesized	519:539	FTIR analysis of final PUA synthesized used for the composite production confirmed the new bonds formed during the polymerization process.
34946764	5	70	dep	abundant	860:867	arg1	%					893:893	12%	891:893	12%	891:893	The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose).
34946764	5	70	dep	abundant	860:867	arg1	abundant					860:867	abundant	860:867	abundant	860:867	The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose).
34946764	5	70	dep	abundant	860:867	arg1	former					844:849	former	844:849	former	844:849	The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose).
34946764	5	70	dep	abundant	860:867	arg1	%					885:885	44%	883:885	44%	883:885	The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose).
34946764	5	71	dep	%	885:885	arg1	lignin					895:900	lignin	895:900	lignin	895:900	The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose).
34946764	0	72	theme	Palm	62:65	arg1	Waste					72:76	Palm Leaf Waste	62:76	Palm Leaf Waste	62:76	Chemical and Mechanical Characterization of Licorice Root and Palm Leaf Waste Incorporated into Poly(urethane-acrylate) (PUA).
34946764	3	73	theme	PUA	525:527	arg1	analysis					507:514	FTIR analysis	502:514	FTIR analysis of final PUA synthesized used for the composite production	502:573	FTIR analysis of final PUA synthesized used for the composite production confirmed the new bonds formed during the polymerization process.
34946764	7	74	theme	strength	1288:1295	arg1	terms					1271:1275	terms	1271:1275	terms of tensile strength	1271:1295	Tensile performance of the composites indicates some reduction with respect to the pure polymer in terms of tensile strength, though stabilizing between data with 5 and 10% filler.
33947564	9	0	with	hydrogel	1694:1701	arg1	streptavidin					1708:1719	streptavidin	1708:1719	streptavidin	1708:1719	The results showed that partially crosslinking the biotinylated HA-based hydrogel with streptavidin has a significant effect on printability and structural integrity.
33947564	2	1	theme	bioprinting	624:634	arg1	technology					636:645	3D bioprinting technology	621:645	3D bioprinting technology	621:645	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	6	2	theme	CaCl2	1199:1203	arg1	solution					1205:1212	CaCl2 solution	1199:1212	CaCl2 solution	1199:1212	Finally, the 3D scaffolds of the HBSA (HBS + alginate) hydrogel were submerged into CaCl2 solution to achieve a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold through ion transfer crosslinking.
33947564	3	3	theme	bond	755:758	arg1	formation					760:768	amide bond formation to form HA-biotin (HAB)	749:792	amide bond formation to form HA-biotin (HAB)	749:792	First, biotinylated hyaluronic acid was synthesized via an adipic acid dihydrazide (ADH) linker with amide bond formation to form HA-biotin (HAB).
33947564	6	4	theme	hydrogel	1257:1264	arg1	scaffold					1266:1273	a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold	1225:1273	a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold	1225:1273	Finally, the 3D scaffolds of the HBSA (HBS + alginate) hydrogel were submerged into CaCl2 solution to achieve a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold through ion transfer crosslinking.
33947564	10	5	theme	hydrogel	1842:1849	arg1	scaffold					1851:1858	a suitable 3D printed HBSAC hydrogel scaffold	1814:1858	a suitable 3D printed HBSAC hydrogel scaffold	1814:1858	Morphological analysis of a suitable 3D printed HBSAC hydrogel scaffold showed visible pores with the desired shape and geometry.
33947564	10	6	theme	printed	1828:1834	arg1	scaffold					1851:1858	a suitable 3D printed HBSAC hydrogel scaffold	1814:1858	a suitable 3D printed HBSAC hydrogel scaffold	1814:1858	Morphological analysis of a suitable 3D printed HBSAC hydrogel scaffold showed visible pores with the desired shape and geometry.
33947564	12	7	theme	chondrogenic	2076:2087	arg1	genes					2096:2100	chondrogenic marker genes	2076:2100	chondrogenic marker genes at day 5	2076:2109	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	4	8	theme	cross-linked	868:879	arg1	hydrogel					910:917	a partially cross-linked HA-biotin-streptavidin (HBS) hydrogel	856:917	a partially cross-linked HA-biotin-streptavidin (HBS) hydrogel	856:917	Both HAB and the as-received streptavidin were mixed to form a partially cross-linked HA-biotin-streptavidin (HBS) hydrogel through noncovalent bonding.
33947564	7	9	theme	3D	1427:1428	arg1	structure					1442:1450	the desired 3D bioprinting structure	1415:1450	the desired 3D bioprinting structure	1415:1450	The physical-chemical characteristics of the hybrid bioink compositions have been evaluated to determine the desired 3D bioprinting structure.
33947564	12	10	theme	quantitative	2216:2227	arg1	assay					2243:2247	quantitative real-time PCR assay	2216:2247	quantitative real-time PCR assay	2216:2247	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	1	11	theme	structural	212:221	arg1	integrity					223:231	the required structural integrity	199:231	the required structural integrity	199:231	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	12	12	theme	genes	2096:2100	arg1	glycosaminoglycans					2124:2141	sulfated glycosaminoglycans	2115:2141	sulfated glycosaminoglycans (sGAGs)	2115:2149	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	12	12	theme	genes	2096:2100	arg1	amounts					2065:2071	significantly higher amounts	2044:2071	significantly higher amounts of chondrogenic marker genes at day 5	2044:2109	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	12	12	theme	genes	2096:2100	arg1	sGAGs					2144:2148	sGAGs	2144:2148	sGAGs	2144:2148	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	12	12	theme	genes	2096:2100	arg1	genes					2096:2100	chondrogenic marker genes	2076:2100	chondrogenic marker genes at day 5	2076:2109	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	6	13	theme	HBS + alginate	1154:1167	arg1	hydrogel					1170:1177	the HBSA (HBS + alginate) hydrogel	1144:1177	the HBSA (HBS + alginate) hydrogel	1144:1177	Finally, the 3D scaffolds of the HBSA (HBS + alginate) hydrogel were submerged into CaCl2 solution to achieve a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold through ion transfer crosslinking.
33947564	12	14	theme	HA	2185:2186	arg1	hydrogel					2188:2195	the HA hydrogel	2181:2195	the HA hydrogel	2181:2195	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	8	15	theme	chondrogenic	1470:1481	arg1	differentiation					1483:1497	chondrogenic differentiation	1470:1497	chondrogenic differentiation	1470:1497	Cytotoxicity and chondrogenic differentiation were also assessed to confirm that the double cross-linked HBSAC hydrogel scaffold was useful for chondrogenic formation.
33947564	6	16	theme	3D	1234:1235	arg1	HBSAC					1237:1241	stable 3D HBSAC	1227:1241	a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold	1225:1273	Finally, the 3D scaffolds of the HBSA (HBS + alginate) hydrogel were submerged into CaCl2 solution to achieve a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold through ion transfer crosslinking.
33947564	5	17	theme	HBSA	1068:1071	arg1	scaffolds					1085:1093	the HBSA hydrogel 3D scaffolds	1064:1093	the HBSA hydrogel 3D scaffolds using a bioprinter	1064:1112	After that, the partially cross-linked HBS hydrogel was mixed with sodium alginate and subsequently printed to form the HBSA hydrogel 3D scaffolds using a bioprinter.
33947564	9	18	theme	significant	1727:1737	arg1	effect					1739:1744	a significant effect	1725:1744	a significant effect	1725:1744	The results showed that partially crosslinking the biotinylated HA-based hydrogel with streptavidin has a significant effect on printability and structural integrity.
33947564	7	19	theme	compositions	1369:1380	arg1	characteristics					1332:1346	The physical-chemical characteristics	1310:1346	The physical-chemical characteristics of the hybrid bioink compositions	1310:1380	The physical-chemical characteristics of the hybrid bioink compositions have been evaluated to determine the desired 3D bioprinting structure.
33947564	6	20	theme	transfer	1287:1294	arg1	crosslinking					1296:1307	ion transfer crosslinking	1283:1307	ion transfer crosslinking	1283:1307	Finally, the 3D scaffolds of the HBSA (HBS + alginate) hydrogel were submerged into CaCl2 solution to achieve a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold through ion transfer crosslinking.
33947564	5	21	theme	3D	1082:1083	arg1	scaffolds					1085:1093	the HBSA hydrogel 3D scaffolds	1064:1093	the HBSA hydrogel 3D scaffolds using a bioprinter	1064:1112	After that, the partially cross-linked HBS hydrogel was mixed with sodium alginate and subsequently printed to form the HBSA hydrogel 3D scaffolds using a bioprinter.
33947564	3	22	theme	hyaluronic	668:677	arg1	acid					679:682	biotinylated hyaluronic acid	655:682	biotinylated hyaluronic acid	655:682	First, biotinylated hyaluronic acid was synthesized via an adipic acid dihydrazide (ADH) linker with amide bond formation to form HA-biotin (HAB).
33947564	7	23	theme	hybrid	1355:1360	arg1	compositions					1369:1380	the hybrid bioink compositions	1351:1380	the hybrid bioink compositions	1351:1380	The physical-chemical characteristics of the hybrid bioink compositions have been evaluated to determine the desired 3D bioprinting structure.
33947564	0	24	theme	3D	73:74	arg1	bioprinting					76:86	3D bioprinting	73:86	3D bioprinting	73:86	Generating adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis.
33947564	1	25	theme	cell-laden	164:173	arg1	scaffolds					184:192	most cell-laden hydrogel scaffolds	159:192	most cell-laden hydrogel scaffolds	159:192	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	2	26	theme	hyaluronic	525:534	arg1	acid					536:539	hyaluronic acid	525:539	hyaluronic acid (HA)-based hydrogels	525:560	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	2	26	theme	hyaluronic	525:534	arg1	HA					542:543	HA	542:543	HA	542:543	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	12	27	theme	HBSAC	2012:2016	arg1	hydrogel					2018:2025	The HBSAC hydrogel	2008:2025	The HBSAC hydrogel	2008:2025	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	1	28	theme	scaffolds	184:192	arg1	Bioprinting					144:154	Bioprinting	144:154	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation	144:320	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	1	28	theme	scaffolds	184:192	arg1	issues					344:349	significant issues	332:349	significant issues that affect the application of bioinks in cartilage tissue engineering	332:420	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	8	29	theme	cross-linked	1545:1556	arg1	scaffold					1573:1580	the double cross-linked HBSAC hydrogel scaffold	1534:1580	the double cross-linked HBSAC hydrogel scaffold	1534:1580	Cytotoxicity and chondrogenic differentiation were also assessed to confirm that the double cross-linked HBSAC hydrogel scaffold was useful for chondrogenic formation.
33947564	8	29	theme	cross-linked	1545:1556	arg1	useful					1586:1591	useful	1586:1591	useful	1586:1591	Cytotoxicity and chondrogenic differentiation were also assessed to confirm that the double cross-linked HBSAC hydrogel scaffold was useful for chondrogenic formation.
33947564	0	30	theme	double	96:101	arg1	strategy					115:122	the double crosslinked strategy	92:122	the double crosslinked strategy for chondrogenesis	92:141	Generating adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis.
33947564	12	31	dep	days	2156:2159	arg1	to					2163:2164	to	2163:2164	to	2163:2164	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	10	32	with	pores	1875:1879	arg1	shape					1898:1902	the desired shape	1886:1902	the desired shape	1886:1902	Morphological analysis of a suitable 3D printed HBSAC hydrogel scaffold showed visible pores with the desired shape and geometry.
33947564	10	32	with	pores	1875:1879	arg1	geometry					1908:1915	geometry	1908:1915	geometry	1908:1915	Morphological analysis of a suitable 3D printed HBSAC hydrogel scaffold showed visible pores with the desired shape and geometry.
33947564	8	33	theme	hydrogel	1564:1571	arg1	scaffold					1573:1580	the double cross-linked HBSAC hydrogel scaffold	1534:1580	the double cross-linked HBSAC hydrogel scaffold	1534:1580	Cytotoxicity and chondrogenic differentiation were also assessed to confirm that the double cross-linked HBSAC hydrogel scaffold was useful for chondrogenic formation.
33947564	8	33	theme	hydrogel	1564:1571	arg1	useful					1586:1591	useful	1586:1591	useful	1586:1591	Cytotoxicity and chondrogenic differentiation were also assessed to confirm that the double cross-linked HBSAC hydrogel scaffold was useful for chondrogenic formation.
33947564	2	34	link	adipose-derived	489:503	arg1	ADSCs					517:521	ADSCs	517:521	ADSCs	517:521	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	2	34	link	adipose-derived	489:503	arg1	cells					510:514	adipose-derived stem cells	489:514	adipose-derived stem cells (ADSCs)	489:522	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	2	34	link	adipose-derived	489:503	arg1	hydrogels					552:560	hyaluronic acid (HA)-based hydrogels	525:560	hyaluronic acid (HA)-based hydrogels	525:560	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	1	35	theme	tissue	403:408	arg1	engineering					410:420	cartilage tissue engineering	393:420	cartilage tissue engineering	393:420	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	2	36	theme	stem	505:508	arg1	ADSCs					517:521	ADSCs	517:521	ADSCs	517:521	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	2	36	theme	stem	505:508	arg1	cells					510:514	adipose-derived stem cells	489:514	adipose-derived stem cells (ADSCs)	489:522	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	2	36	theme	stem	505:508	arg1	hydrogels					552:560	hyaluronic acid (HA)-based hydrogels	525:560	hyaluronic acid (HA)-based hydrogels	525:560	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	12	37	theme	DMMB	2282:2285	arg1	assay					2287:2291	the DMMB assay	2278:2291	the DMMB assay	2278:2291	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	11	38	theme	biocompatibility	1982:1997	arg1	profile					1999:2005	a favorable biocompatibility profile	1970:2005	a favorable biocompatibility profile	1970:2005	We have concluded that the HBSAC hydrogel possesses a favorable biocompatibility profile.
33947564	1	39	from	engineering	410:420	arg1	application					367:377	the application	363:377	the application of bioinks in cartilage tissue engineering	363:420	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	1	40	theme	chondrogenic	293:304	arg1	differentiation					306:320	chondrogenic differentiation	293:320	chondrogenic differentiation	293:320	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	0	41	theme	stem	19:22	arg1	scaffolds					57:65	adipose stem cell-laden hyaluronic acid-based scaffolds	11:65	adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis	11:141	Generating adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis.
33947564	5	42	theme	HBS	987:989	arg1	hydrogel					991:998	the partially cross-linked HBS hydrogel	960:998	the partially cross-linked HBS hydrogel	960:998	After that, the partially cross-linked HBS hydrogel was mixed with sodium alginate and subsequently printed to form the HBSA hydrogel 3D scaffolds using a bioprinter.
33947564	12	43	theme	blue	2260:2263	arg1	staining					2265:2272	Alcian blue staining	2253:2272	Alcian blue staining	2253:2272	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	0	44	theme	hyaluronic	35:44	arg1	scaffolds					57:65	adipose stem cell-laden hyaluronic acid-based scaffolds	11:65	adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis	11:141	Generating adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis.
33947564	1	45	theme	significant	332:342	arg1	Bioprinting					144:154	Bioprinting	144:154	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation	144:320	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	1	45	theme	significant	332:342	arg1	issues					344:349	significant issues	332:349	significant issues that affect the application of bioinks in cartilage tissue engineering	332:420	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	1	46	from	bioinks	382:388	arg1	engineering					410:420	cartilage tissue engineering	393:420	cartilage tissue engineering	393:420	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	9	47	theme	crosslinking	1655:1666	arg1	hydrogel					1694:1701	partially crosslinking the biotinylated HA-based hydrogel	1645:1701	partially crosslinking the biotinylated HA-based hydrogel with streptavidin	1645:1719	The results showed that partially crosslinking the biotinylated HA-based hydrogel with streptavidin has a significant effect on printability and structural integrity.
33947564	1	48	from	application	367:377	arg1	engineering					410:420	cartilage tissue engineering	393:420	cartilage tissue engineering	393:420	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	12	49	from	amounts	2065:2071	arg1	day					2105:2107	day 5	2105:2109	day 5	2105:2109	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	9	50	theme	biotinylated	1672:1683	arg1	hydrogel					1694:1701	partially crosslinking the biotinylated HA-based hydrogel	1645:1701	partially crosslinking the biotinylated HA-based hydrogel with streptavidin	1645:1719	The results showed that partially crosslinking the biotinylated HA-based hydrogel with streptavidin has a significant effect on printability and structural integrity.
33947564	8	51	link	cross-linked	1545:1556	arg1	scaffold					1573:1580	the double cross-linked HBSAC hydrogel scaffold	1534:1580	the double cross-linked HBSAC hydrogel scaffold	1534:1580	Cytotoxicity and chondrogenic differentiation were also assessed to confirm that the double cross-linked HBSAC hydrogel scaffold was useful for chondrogenic formation.
33947564	8	51	link	cross-linked	1545:1556	arg1	useful					1586:1591	useful	1586:1591	useful	1586:1591	Cytotoxicity and chondrogenic differentiation were also assessed to confirm that the double cross-linked HBSAC hydrogel scaffold was useful for chondrogenic formation.
33947564	3	52	theme	dihydrazide	719:729	arg1	linker					737:742	an adipic acid dihydrazide (ADH) linker	704:742	an adipic acid dihydrazide (ADH) linker with amide bond formation to form HA-biotin (HAB)	704:792	First, biotinylated hyaluronic acid was synthesized via an adipic acid dihydrazide (ADH) linker with amide bond formation to form HA-biotin (HAB).
33947564	12	53	theme	PCR	2239:2241	arg1	assay					2243:2247	quantitative real-time PCR assay	2216:2247	quantitative real-time PCR assay	2216:2247	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	3	54	theme	adipic	707:712	arg1	linker					737:742	an adipic acid dihydrazide (ADH) linker	704:742	an adipic acid dihydrazide (ADH) linker with amide bond formation to form HA-biotin (HAB)	704:792	First, biotinylated hyaluronic acid was synthesized via an adipic acid dihydrazide (ADH) linker with amide bond formation to form HA-biotin (HAB).
33947564	4	55	theme	as-received	812:822	arg1	streptavidin					824:835	the as-received streptavidin	808:835	the as-received streptavidin	808:835	Both HAB and the as-received streptavidin were mixed to form a partially cross-linked HA-biotin-streptavidin (HBS) hydrogel through noncovalent bonding.
33947564	10	56	theme	3D	1825:1826	arg1	scaffold					1851:1858	a suitable 3D printed HBSAC hydrogel scaffold	1814:1858	a suitable 3D printed HBSAC hydrogel scaffold	1814:1858	Morphological analysis of a suitable 3D printed HBSAC hydrogel scaffold showed visible pores with the desired shape and geometry.
33947564	12	57	theme	sulfated	2115:2122	arg1	glycosaminoglycans					2124:2141	sulfated glycosaminoglycans	2115:2141	sulfated glycosaminoglycans (sGAGs)	2115:2149	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	12	57	theme	sulfated	2115:2122	arg1	sGAGs					2144:2148	sGAGs	2144:2148	sGAGs	2144:2148	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	0	58	link	crosslinked	103:113	arg1	strategy					115:122	the double crosslinked strategy	92:122	the double crosslinked strategy for chondrogenesis	92:141	Generating adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis.
33947564	6	59	theme	ion	1283:1285	arg1	crosslinking					1296:1307	ion transfer crosslinking	1283:1307	ion transfer crosslinking	1283:1307	Finally, the 3D scaffolds of the HBSA (HBS + alginate) hydrogel were submerged into CaCl2 solution to achieve a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold through ion transfer crosslinking.
33947564	1	60	theme	cell	269:272	arg1	compatibility					274:286	cell compatibility	269:286	cell compatibility	269:286	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	12	61	from	glycosaminoglycans	2124:2141	arg1	day					2105:2107	day 5	2105:2109	day 5	2105:2109	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	4	62	theme	HA-biotin-streptavidin	881:902	arg1	hydrogel					910:917	a partially cross-linked HA-biotin-streptavidin (HBS) hydrogel	856:917	a partially cross-linked HA-biotin-streptavidin (HBS) hydrogel	856:917	Both HAB and the as-received streptavidin were mixed to form a partially cross-linked HA-biotin-streptavidin (HBS) hydrogel through noncovalent bonding.
33947564	3	63	theme	ADH	732:734	arg1	linker					737:742	an adipic acid dihydrazide (ADH) linker	704:742	an adipic acid dihydrazide (ADH) linker with amide bond formation to form HA-biotin (HAB)	704:792	First, biotinylated hyaluronic acid was synthesized via an adipic acid dihydrazide (ADH) linker with amide bond formation to form HA-biotin (HAB).
33947564	10	64	theme	scaffold	1851:1858	arg1	analysis					1802:1809	Morphological analysis	1788:1809	Morphological analysis of a suitable 3D printed HBSAC hydrogel scaffold	1788:1858	Morphological analysis of a suitable 3D printed HBSAC hydrogel scaffold showed visible pores with the desired shape and geometry.
33947564	3	65	with	linker	737:742	arg1	formation					760:768	amide bond formation to form HA-biotin (HAB)	749:792	amide bond formation to form HA-biotin (HAB)	749:792	First, biotinylated hyaluronic acid was synthesized via an adipic acid dihydrazide (ADH) linker with amide bond formation to form HA-biotin (HAB).
33947564	6	66	theme	hydrogel	1170:1177	arg1	scaffolds					1131:1139	the 3D scaffolds	1124:1139	the 3D scaffolds of the HBSA (HBS + alginate) hydrogel	1124:1177	Finally, the 3D scaffolds of the HBSA (HBS + alginate) hydrogel were submerged into CaCl2 solution to achieve a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold through ion transfer crosslinking.
33947564	2	67	theme	3D	621:622	arg1	technology					636:645	3D bioprinting technology	621:645	3D bioprinting technology	621:645	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	9	68	theme	HA-based	1685:1692	arg1	hydrogel					1694:1701	partially crosslinking the biotinylated HA-based hydrogel	1645:1701	partially crosslinking the biotinylated HA-based hydrogel with streptavidin	1645:1719	The results showed that partially crosslinking the biotinylated HA-based hydrogel with streptavidin has a significant effect on printability and structural integrity.
33947564	10	69	theme	HBSAC	1836:1840	arg1	scaffold					1851:1858	a suitable 3D printed HBSAC hydrogel scaffold	1814:1858	a suitable 3D printed HBSAC hydrogel scaffold	1814:1858	Morphological analysis of a suitable 3D printed HBSAC hydrogel scaffold showed visible pores with the desired shape and geometry.
33947564	12	70	from	day	2105:2107	arg1	glycosaminoglycans					2124:2141	sulfated glycosaminoglycans	2115:2141	sulfated glycosaminoglycans (sGAGs)	2115:2149	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	12	70	from	day	2105:2107	arg1	amounts					2065:2071	significantly higher amounts	2044:2071	significantly higher amounts of chondrogenic marker genes at day 5	2044:2109	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	12	70	from	day	2105:2107	arg1	sGAGs					2144:2148	sGAGs	2144:2148	sGAGs	2144:2148	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	12	70	from	day	2105:2107	arg1	genes					2096:2100	chondrogenic marker genes	2076:2100	chondrogenic marker genes at day 5	2076:2109	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	3	71	theme	amide	749:753	arg1	formation					760:768	amide bond formation to form HA-biotin (HAB)	749:792	amide bond formation to form HA-biotin (HAB)	749:792	First, biotinylated hyaluronic acid was synthesized via an adipic acid dihydrazide (ADH) linker with amide bond formation to form HA-biotin (HAB).
33947564	1	72	theme	required	203:210	arg1	integrity					223:231	the required structural integrity	199:231	the required structural integrity	199:231	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	9	73	theme	structural	1766:1775	arg1	integrity					1777:1785	structural integrity	1766:1785	structural integrity	1766:1785	The results showed that partially crosslinking the biotinylated HA-based hydrogel with streptavidin has a significant effect on printability and structural integrity.
33947564	7	74	theme	bioprinting	1430:1440	arg1	structure					1442:1450	the desired 3D bioprinting structure	1415:1450	the desired 3D bioprinting structure	1415:1450	The physical-chemical characteristics of the hybrid bioink compositions have been evaluated to determine the desired 3D bioprinting structure.
33947564	10	75	theme	visible	1867:1873	arg1	pores					1875:1879	visible pores	1867:1879	visible pores with the desired shape and geometry	1867:1915	Morphological analysis of a suitable 3D printed HBSAC hydrogel scaffold showed visible pores with the desired shape and geometry.
33947564	12	76	theme	marker	2089:2094	arg1	genes					2096:2100	chondrogenic marker genes	2076:2100	chondrogenic marker genes at day 5	2076:2109	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	7	77	theme	desired	1419:1425	arg1	structure					1442:1450	the desired 3D bioprinting structure	1415:1450	the desired 3D bioprinting structure	1415:1450	The physical-chemical characteristics of the hybrid bioink compositions have been evaluated to determine the desired 3D bioprinting structure.
33947564	4	78	link	cross-linked	868:879	arg1	hydrogel					910:917	a partially cross-linked HA-biotin-streptavidin (HBS) hydrogel	856:917	a partially cross-linked HA-biotin-streptavidin (HBS) hydrogel	856:917	Both HAB and the as-received streptavidin were mixed to form a partially cross-linked HA-biotin-streptavidin (HBS) hydrogel through noncovalent bonding.
33947564	11	79	theme	HBSAC	1945:1949	arg1	hydrogel					1951:1958	the HBSAC hydrogel	1941:1958	the HBSAC hydrogel	1941:1958	We have concluded that the HBSAC hydrogel possesses a favorable biocompatibility profile.
33947564	1	80	theme	mechanical	234:243	arg1	modulus					245:251	mechanical modulus	234:251	mechanical modulus	234:251	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	6	81	theme	HBSAC	1237:1241	arg1	scaffold					1266:1273	a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold	1225:1273	a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold	1225:1273	Finally, the 3D scaffolds of the HBSA (HBS + alginate) hydrogel were submerged into CaCl2 solution to achieve a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold through ion transfer crosslinking.
33947564	10	82	theme	desired	1890:1896	arg1	shape					1898:1902	the desired shape	1886:1902	the desired shape	1886:1902	Morphological analysis of a suitable 3D printed HBSAC hydrogel scaffold showed visible pores with the desired shape and geometry.
33947564	12	83	theme	higher	2058:2063	arg1	amounts					2065:2071	significantly higher amounts	2044:2071	significantly higher amounts of chondrogenic marker genes at day 5	2044:2109	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	12	83	theme	higher	2058:2063	arg1	genes					2096:2100	chondrogenic marker genes	2076:2100	chondrogenic marker genes at day 5	2076:2109	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	6	84	theme	stable	1227:1232	arg1	HBSAC					1237:1241	stable 3D HBSAC	1227:1241	a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold	1225:1273	Finally, the 3D scaffolds of the HBSA (HBS + alginate) hydrogel were submerged into CaCl2 solution to achieve a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold through ion transfer crosslinking.
33947564	5	85	theme	hydrogel	1073:1080	arg1	scaffolds					1085:1093	the HBSA hydrogel 3D scaffolds	1064:1093	the HBSA hydrogel 3D scaffolds using a bioprinter	1064:1112	After that, the partially cross-linked HBS hydrogel was mixed with sodium alginate and subsequently printed to form the HBSA hydrogel 3D scaffolds using a bioprinter.
33947564	3	86	theme	biotinylated	655:666	arg1	acid					679:682	biotinylated hyaluronic acid	655:682	biotinylated hyaluronic acid	655:682	First, biotinylated hyaluronic acid was synthesized via an adipic acid dihydrazide (ADH) linker with amide bond formation to form HA-biotin (HAB).
33947564	4	87	theme	noncovalent	927:937	arg1	bonding					939:945	noncovalent bonding	927:945	noncovalent bonding	927:945	Both HAB and the as-received streptavidin were mixed to form a partially cross-linked HA-biotin-streptavidin (HBS) hydrogel through noncovalent bonding.
33947564	1	88	theme	most	159:162	arg1	scaffolds					184:192	most cell-laden hydrogel scaffolds	159:192	most cell-laden hydrogel scaffolds	159:192	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	2	89	theme	acid	536:539	arg1	cells					510:514	adipose-derived stem cells	489:514	adipose-derived stem cells (ADSCs)	489:522	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	2	89	theme	acid	536:539	arg1	hydrogels					552:560	hyaluronic acid (HA)-based hydrogels	525:560	hyaluronic acid (HA)-based hydrogels	525:560	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	8	90	theme	double	1538:1543	arg1	scaffold					1573:1580	the double cross-linked HBSAC hydrogel scaffold	1534:1580	the double cross-linked HBSAC hydrogel scaffold	1534:1580	Cytotoxicity and chondrogenic differentiation were also assessed to confirm that the double cross-linked HBSAC hydrogel scaffold was useful for chondrogenic formation.
33947564	8	90	theme	double	1538:1543	arg1	useful					1586:1591	useful	1586:1591	useful	1586:1591	Cytotoxicity and chondrogenic differentiation were also assessed to confirm that the double cross-linked HBSAC hydrogel scaffold was useful for chondrogenic formation.
33947564	7	91	theme	bioink	1362:1367	arg1	compositions					1369:1380	the hybrid bioink compositions	1351:1380	the hybrid bioink compositions	1351:1380	The physical-chemical characteristics of the hybrid bioink compositions have been evaluated to determine the desired 3D bioprinting structure.
33947564	1	92	theme	hydrogel	175:182	arg1	scaffolds					184:192	most cell-laden hydrogel scaffolds	159:192	most cell-laden hydrogel scaffolds	159:192	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	8	93	theme	HBSAC	1558:1562	arg1	scaffold					1573:1580	the double cross-linked HBSAC hydrogel scaffold	1534:1580	the double cross-linked HBSAC hydrogel scaffold	1534:1580	Cytotoxicity and chondrogenic differentiation were also assessed to confirm that the double cross-linked HBSAC hydrogel scaffold was useful for chondrogenic formation.
33947564	8	93	theme	HBSAC	1558:1562	arg1	useful					1586:1591	useful	1586:1591	useful	1586:1591	Cytotoxicity and chondrogenic differentiation were also assessed to confirm that the double cross-linked HBSAC hydrogel scaffold was useful for chondrogenic formation.
33947564	6	94	dep	HBSAC	1237:1241	arg1	Ca2+					1251:1254	Ca2+	1251:1254	Ca2+	1251:1254	Finally, the 3D scaffolds of the HBSA (HBS + alginate) hydrogel were submerged into CaCl2 solution to achieve a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold through ion transfer crosslinking.
33947564	6	94	dep	HBSAC	1237:1241	arg1	HBSA					1244:1247	HBSA	1244:1247	HBSA	1244:1247	Finally, the 3D scaffolds of the HBSA (HBS + alginate) hydrogel were submerged into CaCl2 solution to achieve a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold through ion transfer crosslinking.
33947564	0	95	theme	crosslinked	103:113	arg1	strategy					115:122	the double crosslinked strategy	92:122	the double crosslinked strategy for chondrogenesis	92:141	Generating adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis.
33947564	1	96	theme	bioinks	382:388	arg1	application					367:377	the application	363:377	the application of bioinks in cartilage tissue engineering	363:420	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	2	97	theme	-based	545:550	arg1	cells					510:514	adipose-derived stem cells	489:514	adipose-derived stem cells (ADSCs)	489:522	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	2	97	theme	-based	545:550	arg1	hydrogels					552:560	hyaluronic acid (HA)-based hydrogels	525:560	hyaluronic acid (HA)-based hydrogels	525:560	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	1	98	theme	cartilage	393:401	arg1	engineering					410:420	cartilage tissue engineering	393:420	cartilage tissue engineering	393:420	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	1	99	with	Bioprinting	144:154	arg1	adhesion					259:266	cell adhesion	254:266	cell adhesion	254:266	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	1	99	with	Bioprinting	144:154	arg1	compatibility					274:286	cell compatibility	269:286	cell compatibility	269:286	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	1	99	with	Bioprinting	144:154	arg1	differentiation					306:320	chondrogenic differentiation	293:320	chondrogenic differentiation	293:320	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	1	99	with	Bioprinting	144:154	arg1	integrity					223:231	the required structural integrity	199:231	the required structural integrity	199:231	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	1	99	with	Bioprinting	144:154	arg1	modulus					245:251	mechanical modulus	234:251	mechanical modulus	234:251	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	0	100	theme	adipose	11:17	arg1	scaffolds					57:65	adipose stem cell-laden hyaluronic acid-based scaffolds	11:65	adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis	11:141	Generating adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis.
33947564	7	101	theme	physical-chemical	1314:1330	arg1	characteristics					1332:1346	The physical-chemical characteristics	1310:1346	The physical-chemical characteristics of the hybrid bioink compositions	1310:1380	The physical-chemical characteristics of the hybrid bioink compositions have been evaluated to determine the desired 3D bioprinting structure.
33947564	2	102	theme	adipose-derived	489:503	arg1	ADSCs					517:521	ADSCs	517:521	ADSCs	517:521	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	2	102	theme	adipose-derived	489:503	arg1	cells					510:514	adipose-derived stem cells	489:514	adipose-derived stem cells (ADSCs)	489:522	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	2	102	theme	adipose-derived	489:503	arg1	hydrogels					552:560	hyaluronic acid (HA)-based hydrogels	525:560	hyaluronic acid (HA)-based hydrogels	525:560	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	8	103	theme	chondrogenic	1597:1608	arg1	formation					1610:1618	chondrogenic formation	1597:1618	chondrogenic formation	1597:1618	Cytotoxicity and chondrogenic differentiation were also assessed to confirm that the double cross-linked HBSAC hydrogel scaffold was useful for chondrogenic formation.
33947564	9	104	contain	has	1721:1723	arg1	hydrogel					1694:1701	partially crosslinking the biotinylated HA-based hydrogel	1645:1701	partially crosslinking the biotinylated HA-based hydrogel with streptavidin	1645:1719	The results showed that partially crosslinking the biotinylated HA-based hydrogel with streptavidin has a significant effect on printability and structural integrity.
33947564	9	104	contain	has	1721:1723	arg2	effect					1739:1744	a significant effect	1725:1744	a significant effect	1725:1744	The results showed that partially crosslinking the biotinylated HA-based hydrogel with streptavidin has a significant effect on printability and structural integrity.
33947564	0	105	theme	cell-laden	24:33	arg1	scaffolds					57:65	adipose stem cell-laden hyaluronic acid-based scaffolds	11:65	adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis	11:141	Generating adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis.
33947564	11	106	contain	possesses	1960:1968	arg2	profile					1999:2005	a favorable biocompatibility profile	1970:2005	a favorable biocompatibility profile	1970:2005	We have concluded that the HBSAC hydrogel possesses a favorable biocompatibility profile.
33947564	11	106	contain	possesses	1960:1968	arg1	hydrogel					1951:1958	the HBSAC hydrogel	1941:1958	the HBSAC hydrogel	1941:1958	We have concluded that the HBSAC hydrogel possesses a favorable biocompatibility profile.
33947564	5	107	theme	cross-linked	974:985	arg1	hydrogel					991:998	the partially cross-linked HBS hydrogel	960:998	the partially cross-linked HBS hydrogel	960:998	After that, the partially cross-linked HBS hydrogel was mixed with sodium alginate and subsequently printed to form the HBSA hydrogel 3D scaffolds using a bioprinter.
33947564	2	108	theme	printable	458:466	arg1	bioinks					468:474	printable bioinks	458:474	printable bioinks	458:474	This study focuses on constructing printable bioinks by combining adipose-derived stem cells (ADSCs), hyaluronic acid (HA)-based hydrogels and analyzing their ability to induce chondrogenesis using 3D bioprinting technology.
33947564	0	109	theme	acid-based	46:55	arg1	scaffolds					57:65	adipose stem cell-laden hyaluronic acid-based scaffolds	11:65	adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis	11:141	Generating adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis.
33947564	12	110	theme	Alcian	2253:2258	arg1	staining					2265:2272	Alcian blue staining	2253:2272	Alcian blue staining	2253:2272	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	6	111	theme	HBSA	1148:1151	arg1	hydrogel					1170:1177	the HBSA (HBS + alginate) hydrogel	1144:1177	the HBSA (HBS + alginate) hydrogel	1144:1177	Finally, the 3D scaffolds of the HBSA (HBS + alginate) hydrogel were submerged into CaCl2 solution to achieve a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold through ion transfer crosslinking.
33947564	3	112	theme	acid	714:717	arg1	linker					737:742	an adipic acid dihydrazide (ADH) linker	704:742	an adipic acid dihydrazide (ADH) linker with amide bond formation to form HA-biotin (HAB)	704:792	First, biotinylated hyaluronic acid was synthesized via an adipic acid dihydrazide (ADH) linker with amide bond formation to form HA-biotin (HAB).
33947564	10	113	theme	Morphological	1788:1800	arg1	analysis					1802:1809	Morphological analysis	1788:1809	Morphological analysis of a suitable 3D printed HBSAC hydrogel scaffold	1788:1858	Morphological analysis of a suitable 3D printed HBSAC hydrogel scaffold showed visible pores with the desired shape and geometry.
33947564	5	114	theme	sodium	1015:1020	arg1	alginate					1022:1029	sodium alginate	1015:1029	sodium alginate	1015:1029	After that, the partially cross-linked HBS hydrogel was mixed with sodium alginate and subsequently printed to form the HBSA hydrogel 3D scaffolds using a bioprinter.
33947564	12	115	theme	real-time	2229:2237	arg1	assay					2243:2247	quantitative real-time PCR assay	2216:2247	quantitative real-time PCR assay	2216:2247	The HBSAC hydrogel can also secrete significantly higher amounts of chondrogenic marker genes at day 5 and sulfated glycosaminoglycans (sGAGs) from days 7 to 14 compared to the HA hydrogel, as determined via quantitative real-time PCR assay and Alcian blue staining and the DMMB assay.
33947564	11	116	theme	favorable	1972:1980	arg1	profile					1999:2005	a favorable biocompatibility profile	1970:2005	a favorable biocompatibility profile	1970:2005	We have concluded that the HBSAC hydrogel possesses a favorable biocompatibility profile.
33947564	1	117	theme	cell	254:257	arg1	adhesion					259:266	cell adhesion	254:266	cell adhesion	254:266	Bioprinting of most cell-laden hydrogel scaffolds with the required structural integrity, mechanical modulus, cell adhesion, cell compatibility, and chondrogenic differentiation are still significant issues that affect the application of bioinks in cartilage tissue engineering.
33947564	5	118	link	cross-linked	974:985	arg1	hydrogel					991:998	the partially cross-linked HBS hydrogel	960:998	the partially cross-linked HBS hydrogel	960:998	After that, the partially cross-linked HBS hydrogel was mixed with sodium alginate and subsequently printed to form the HBSA hydrogel 3D scaffolds using a bioprinter.
33947564	6	119	theme	3D	1128:1129	arg1	scaffolds					1131:1139	the 3D scaffolds	1124:1139	the 3D scaffolds of the HBSA (HBS + alginate) hydrogel	1124:1177	Finally, the 3D scaffolds of the HBSA (HBS + alginate) hydrogel were submerged into CaCl2 solution to achieve a stable 3D HBSAC (HBSA + Ca2+) hydrogel scaffold through ion transfer crosslinking.
33947564	10	120	theme	suitable	1816:1823	arg1	scaffold					1851:1858	a suitable 3D printed HBSAC hydrogel scaffold	1814:1858	a suitable 3D printed HBSAC hydrogel scaffold	1814:1858	Morphological analysis of a suitable 3D printed HBSAC hydrogel scaffold showed visible pores with the desired shape and geometry.
34289430	0	0	theme	enzymatic	91:99	arg1	susceptibility					101:114	enzymatic susceptibility	91:114	enzymatic susceptibility	91:114	Subcritical water pretreatment for agave bagasse fractionation from tequila production and enzymatic susceptibility.
34289430	4	1	theme	cellulose	599:607	arg1	content					609:615	the increased cellulose content	585:615	the increased cellulose content (>50%) in the pretreated solid phase	585:652	The best operational conditions were selected, based on the increased cellulose content (>50%) in the pretreated solid phase.
34289430	4	1	theme	cellulose	599:607	arg1	%					621:621	>50%	618:621	>50%	618:621	The best operational conditions were selected, based on the increased cellulose content (>50%) in the pretreated solid phase.
34289430	3	2	theme	subcritical	463:473	arg1	pretreatment					481:492	subcritical water pretreatment	463:492	subcritical water pretreatment	463:492	The operational conditions for subcritical water pretreatment were (150-190 °C) and (10-50 min).
34289430	1	3	theme	water	164:168	arg1	conditions					183:192	subcritical water pretreatment conditions	152:192	subcritical water pretreatment conditions	152:192	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	5	4	theme	enzymatic	750:758	arg1	susceptibility					771:784	enzymatic hydrolysis susceptibility	750:784	enzymatic hydrolysis susceptibility (15 FPU/g of the substrate)	750:812	The conditions for 190 °C for 50 and 30 min of pretreated agave bagasse solids were chosen for enzymatic hydrolysis susceptibility (15 FPU/g of the substrate).
34289430	7	5	from	material	1085:1092	arg1	development					1101:1111	the development	1097:1111	the development of second-generation biorefineries	1097:1146	This study indicates that the agave bagasse is a promising raw material in the development of second-generation biorefineries.
34289430	7	6	theme	promising	1071:1079	arg1	material					1085:1092	a promising raw material	1069:1092	a promising raw material in the development of second-generation biorefineries	1069:1146	This study indicates that the agave bagasse is a promising raw material in the development of second-generation biorefineries.
34289430	7	6	theme	promising	1071:1079	arg1	bagasse					1058:1064	the agave bagasse	1048:1064	the agave bagasse	1048:1064	This study indicates that the agave bagasse is a promising raw material in the development of second-generation biorefineries.
34289430	6	7	theme	maximum	819:825	arg1	yield					838:842	The maximum conversion yield	815:842	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved	815:902	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	6	7	theme	maximum	819:825	arg1	%					919:919	up to 61.62%	908:919	up to 61.62% (5.86 g/L)	908:930	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	2	8	theme	batch	377:381	arg1	reactor					395:401	a batch pressurized reactor	375:401	a batch pressurized reactor	375:401	The pretreatment was carried out in a batch pressurized reactor within an isothermal regime.
34289430	6	9	theme	saccharification	974:989	arg1	rate					991:994	initial saccharification rate	966:994	initial saccharification rate	966:994	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	4	10	theme	operational	538:548	arg1	conditions					550:559	The best operational conditions	529:559	The best operational conditions	529:559	The best operational conditions were selected, based on the increased cellulose content (>50%) in the pretreated solid phase.
34289430	6	11	from	12 h	1016:1019	arg1	0.34 g/					1000:1006	0.34 g/	1000:1006	0.34 g/	1000:1006	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	6	12	theme	initial	966:972	arg1	rate					991:994	initial saccharification rate	966:994	initial saccharification rate	966:994	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	6	13	dep	0.34 g/	1000:1006	arg1	h					1010:1010	L*h	1008:1010	L*h	1008:1010	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	2	14	theme	pressurized	383:393	arg1	reactor					395:401	a batch pressurized reactor	375:401	a batch pressurized reactor	375:401	The pretreatment was carried out in a batch pressurized reactor within an isothermal regime.
34289430	6	15	dep	61.62	914:918	arg1	to					911:912	to	911:912	to	911:912	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	1	16	theme	agave	197:201	arg1	composition					220:230	agave bagasse chemical composition	197:230	agave bagasse chemical composition	197:230	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	1	17	theme	conditions	183:192	arg1	effect					142:147	the effect	138:147	the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes	138:336	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	4	18	from	content	609:615	arg1	phase					648:652	the pretreated solid phase	627:652	the pretreated solid phase	627:652	The best operational conditions were selected, based on the increased cellulose content (>50%) in the pretreated solid phase.
34289430	7	19	theme	agave	1052:1056	arg1	material					1085:1092	a promising raw material	1069:1092	a promising raw material in the development of second-generation biorefineries	1069:1146	This study indicates that the agave bagasse is a promising raw material in the development of second-generation biorefineries.
34289430	7	19	theme	agave	1052:1056	arg1	bagasse					1058:1064	the agave bagasse	1048:1064	the agave bagasse	1048:1064	This study indicates that the agave bagasse is a promising raw material in the development of second-generation biorefineries.
34289430	7	20	theme	biorefineries	1134:1146	arg1	development					1101:1111	the development	1097:1111	the development of second-generation biorefineries	1097:1146	This study indicates that the agave bagasse is a promising raw material in the development of second-generation biorefineries.
34289430	0	21	theme	water	12:16	arg1	pretreatment					18:29	Subcritical water pretreatment	0:29	Subcritical water pretreatment for agave	0:39	Subcritical water pretreatment for agave bagasse fractionation from tequila production and enzymatic susceptibility.
34289430	6	22	theme	*	1009:1009	arg1	h					1010:1010	L*h	1008:1010	L*h	1008:1010	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	6	23	from	72 h	957:960	arg1	5.86 g/L					922:929	5.86 g/L	922:929	5.86 g/L	922:929	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	6	23	from	72 h	957:960	arg1	yield					838:842	The maximum conversion yield	815:842	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved	815:902	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	6	23	from	72 h	957:960	arg1	%					919:919	up to 61.62%	908:919	up to 61.62% (5.86 g/L)	908:930	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	1	24	from	effect	142:147	arg1	composition					220:230	agave bagasse chemical composition	197:230	agave bagasse chemical composition	197:230	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	1	24	from	effect	142:147	arg1	fractionation					241:253	biomass fractionation	233:253	biomass fractionation	233:253	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	1	24	from	effect	142:147	arg1	hydrolysis					270:279	enzymatic hydrolysis	260:279	enzymatic hydrolysis	260:279	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	7	25	theme	second-generation	1116:1132	arg1	biorefineries					1134:1146	second-generation biorefineries	1116:1146	second-generation biorefineries	1116:1146	This study indicates that the agave bagasse is a promising raw material in the development of second-generation biorefineries.
34289430	2	26	theme	isothermal	413:422	arg1	regime					424:429	an isothermal regime	410:429	an isothermal regime	410:429	The pretreatment was carried out in a batch pressurized reactor within an isothermal regime.
34289430	0	27	theme	Subcritical	0:10	arg1	pretreatment					18:29	Subcritical water pretreatment	0:29	Subcritical water pretreatment for agave	0:39	Subcritical water pretreatment for agave bagasse fractionation from tequila production and enzymatic susceptibility.
34289430	1	28	theme	different	299:307	arg1	processes					328:336	the different tequila production processes	295:336	the different tequila production processes	295:336	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	6	29	theme	conversion	827:836	arg1	yield					838:842	The maximum conversion yield	815:842	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved	815:902	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	6	29	theme	conversion	827:836	arg1	%					919:919	up to 61.62%	908:919	up to 61.62% (5.86 g/L)	908:930	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	1	30	theme	bagasse	203:209	arg1	composition					220:230	agave bagasse chemical composition	197:230	agave bagasse chemical composition	197:230	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	1	31	theme	tequila	309:315	arg1	processes					328:336	the different tequila production processes	295:336	the different tequila production processes	295:336	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	5	32	theme	pretreated	702:711	arg1	solids					727:732	pretreated agave bagasse solids	702:732	pretreated agave bagasse solids	702:732	The conditions for 190 °C for 50 and 30 min of pretreated agave bagasse solids were chosen for enzymatic hydrolysis susceptibility (15 FPU/g of the substrate).
34289430	1	33	theme	chemical	211:218	arg1	composition					220:230	agave bagasse chemical composition	197:230	agave bagasse chemical composition	197:230	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	1	34	theme	production	317:326	arg1	processes					328:336	the different tequila production processes	295:336	the different tequila production processes	295:336	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	5	35	theme	agave	713:717	arg1	solids					727:732	pretreated agave bagasse solids	702:732	pretreated agave bagasse solids	702:732	The conditions for 190 °C for 50 and 30 min of pretreated agave bagasse solids were chosen for enzymatic hydrolysis susceptibility (15 FPU/g of the substrate).
34289430	1	36	theme	pretreatment	170:181	arg1	conditions					183:192	subcritical water pretreatment conditions	152:192	subcritical water pretreatment conditions	152:192	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	4	37	theme	solid	642:646	arg1	phase					648:652	the pretreated solid phase	627:652	the pretreated solid phase	627:652	The best operational conditions were selected, based on the increased cellulose content (>50%) in the pretreated solid phase.
34289430	4	38	theme	increased	589:597	arg1	content					609:615	the increased cellulose content	585:615	the increased cellulose content (>50%) in the pretreated solid phase	585:652	The best operational conditions were selected, based on the increased cellulose content (>50%) in the pretreated solid phase.
34289430	4	38	theme	increased	589:597	arg1	%					621:621	>50%	618:621	>50%	618:621	The best operational conditions were selected, based on the increased cellulose content (>50%) in the pretreated solid phase.
34289430	5	39	theme	bagasse	719:725	arg1	solids					727:732	pretreated agave bagasse solids	702:732	pretreated agave bagasse solids	702:732	The conditions for 190 °C for 50 and 30 min of pretreated agave bagasse solids were chosen for enzymatic hydrolysis susceptibility (15 FPU/g of the substrate).
34289430	6	40	theme	industrial	935:944	arg1	bagasse					946:952	industrial bagasse	935:952	industrial bagasse	935:952	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	3	41	theme	water	475:479	arg1	pretreatment					481:492	subcritical water pretreatment	463:492	subcritical water pretreatment	463:492	The operational conditions for subcritical water pretreatment were (150-190 °C) and (10-50 min).
34289430	5	42	theme	solids	727:732	arg1	50					685:686	50	685:686	50	685:686	The conditions for 190 °C for 50 and 30 min of pretreated agave bagasse solids were chosen for enzymatic hydrolysis susceptibility (15 FPU/g of the substrate).
34289430	5	42	theme	solids	727:732	arg1	solids					727:732	pretreated agave bagasse solids	702:732	pretreated agave bagasse solids	702:732	The conditions for 190 °C for 50 and 30 min of pretreated agave bagasse solids were chosen for enzymatic hydrolysis susceptibility (15 FPU/g of the substrate).
34289430	0	43	from	production	76:85	arg1	fractionation					49:61	fractionation	49:61	fractionation from tequila production and enzymatic susceptibility	49:114	Subcritical water pretreatment for agave bagasse fractionation from tequila production and enzymatic susceptibility.
34289430	1	44	theme	biomass	233:239	arg1	fractionation					241:253	biomass fractionation	233:253	biomass fractionation	233:253	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	7	45	theme	raw	1081:1083	arg1	material					1085:1092	a promising raw material	1069:1092	a promising raw material in the development of second-generation biorefineries	1069:1146	This study indicates that the agave bagasse is a promising raw material in the development of second-generation biorefineries.
34289430	7	45	theme	raw	1081:1083	arg1	bagasse					1058:1064	the agave bagasse	1048:1064	the agave bagasse	1048:1064	This study indicates that the agave bagasse is a promising raw material in the development of second-generation biorefineries.
34289430	5	46	theme	substrate	803:811	arg1	FPU/g					790:794	15 FPU/g	787:794	15 FPU/g of the substrate	787:811	The conditions for 190 °C for 50 and 30 min of pretreated agave bagasse solids were chosen for enzymatic hydrolysis susceptibility (15 FPU/g of the substrate).
34289430	3	47	theme	operational	436:446	arg1	150-190 °C					500:509	150-190 °C	500:509	150-190 °C	500:509	The operational conditions for subcritical water pretreatment were (150-190 °C) and (10-50 min).
34289430	3	47	theme	operational	436:446	arg1	conditions					448:457	The operational conditions	432:457	The operational conditions for subcritical water pretreatment	432:492	The operational conditions for subcritical water pretreatment were (150-190 °C) and (10-50 min).
34289430	6	48	dep	yield	838:842	arg1	cellulose					845:853	cellulose	845:853	cellulose to glucose	845:864	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	6	49	theme	enzymatic	874:882	arg1	hydrolysis					884:893	enzymatic hydrolysis	874:893	enzymatic hydrolysis achieved	874:902	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	5	50	dep	susceptibility	771:784	arg1	FPU/g					790:794	15 FPU/g	787:794	15 FPU/g of the substrate	787:811	The conditions for 190 °C for 50 and 30 min of pretreated agave bagasse solids were chosen for enzymatic hydrolysis susceptibility (15 FPU/g of the substrate).
34289430	6	51	theme	L	1008:1008	arg1	h					1010:1010	L*h	1008:1010	L*h	1008:1010	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	5	52	theme	hydrolysis	760:769	arg1	susceptibility					771:784	enzymatic hydrolysis susceptibility	750:784	enzymatic hydrolysis susceptibility (15 FPU/g of the substrate)	750:812	The conditions for 190 °C for 50 and 30 min of pretreated agave bagasse solids were chosen for enzymatic hydrolysis susceptibility (15 FPU/g of the substrate).
34289430	0	53	from	susceptibility	101:114	arg1	fractionation					49:61	fractionation	49:61	fractionation from tequila production and enzymatic susceptibility	49:114	Subcritical water pretreatment for agave bagasse fractionation from tequila production and enzymatic susceptibility.
34289430	4	54	theme	pretreated	631:640	arg1	phase					648:652	the pretreated solid phase	627:652	the pretreated solid phase	627:652	The best operational conditions were selected, based on the increased cellulose content (>50%) in the pretreated solid phase.
34289430	0	55	theme	tequila	68:74	arg1	production					76:85	tequila production	68:85	tequila production	68:85	Subcritical water pretreatment for agave bagasse fractionation from tequila production and enzymatic susceptibility.
34289430	4	56	theme	best	533:536	arg1	conditions					550:559	The best operational conditions	529:559	The best operational conditions	529:559	The best operational conditions were selected, based on the increased cellulose content (>50%) in the pretreated solid phase.
34289430	1	57	theme	subcritical	152:162	arg1	conditions					183:192	subcritical water pretreatment conditions	152:192	subcritical water pretreatment conditions	152:192	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
34289430	6	58	from	%	919:919	arg1	bagasse					946:952	industrial bagasse	935:952	industrial bagasse	935:952	The maximum conversion yield (cellulose to glucose) during enzymatic hydrolysis achieved was up to 61.62% (5.86 g/L) in industrial bagasse at 72 h and initial saccharification rate was 0.34 g/(L*h) at 12 h.
34289430	1	59	theme	enzymatic	260:268	arg1	hydrolysis					270:279	enzymatic hydrolysis	260:279	enzymatic hydrolysis	260:279	This work focuses on the effect of subcritical water pretreatment conditions on agave bagasse chemical composition, biomass fractionation, and enzymatic hydrolysis obtained from the different tequila production processes.
32649504	12	0	theme	earlier	2279:2285	arg1	resumption					2287:2296	earlier resumption	2279:2296	earlier resumption of therapeutic anticoagulation	2279:2327	Complications were associated with earlier resumption of therapeutic anticoagulation, particularly before 9.25 hours for vaginal deliveries and before 15.1 hours for cesarean deliveries.
32649504	8	1	contain	had	1667:1669	arg2	complications					1671:1683	complications	1671:1683	complications	1671:1683	For vaginal deliveries, 8 of 51 (15.7%) women had complications when anticoagulation was started before 9.25 hours postpartum, compared with 1 of 98 (1.0%) when started after 9.25 hours.
32649504	8	1	contain	had	1667:1669	arg1	women					1661:1665	8 of 51 (15.7%) women	1645:1665	8 of 51 (15.7%) women	1645:1665	For vaginal deliveries, 8 of 51 (15.7%) women had complications when anticoagulation was started before 9.25 hours postpartum, compared with 1 of 98 (1.0%) when started after 9.25 hours.
32649504	10	2	theme	venous	2009:2014	arg1	thromboembolism					2016:2030	venous thromboembolism	2009:2030	venous thromboembolism	2009:2030	Two (0.9%) episodes of venous thromboembolism occurred within 6 weeks postpartum.
32649504	3	3	theme	weeks	598:602	arg1	postpartum					604:613	6 weeks postpartum	596:613	6 weeks postpartum	596:613	Secondary outcomes included minor complications, risk factors associated with total complications (including the time to therapeutic anticoagulation resumption after delivery) and recurrent thrombotic events within 6 weeks postpartum.
32649504	8	4	theme	vaginal	1625:1631	arg1	deliveries					1633:1642	vaginal deliveries	1625:1642	vaginal deliveries	1625:1642	For vaginal deliveries, 8 of 51 (15.7%) women had complications when anticoagulation was started before 9.25 hours postpartum, compared with 1 of 98 (1.0%) when started after 9.25 hours.
32649504	5	5	theme	primary	884:890	arg1	complications					1072:1084	major wound complications	1060:1084	major wound complications	1060:1084	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	5	5	theme	primary	884:890	arg1	outcome					892:898	The primary outcome	880:898	The primary outcome	880:898	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	5	5	theme	primary	884:890	arg1	composite					903:911	a composite	901:911	a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications	901:1084	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	5	5	theme	primary	884:890	arg1	complications					934:946	major hemorrhagic complications	916:946	major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery)	916:1054	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	7	6	theme	median	1459:1464	arg1	delay					1466:1470	the median delay	1455:1470	the median delay before resuming anticoagulation	1455:1502	When comparing cases associated with and without complications, the median delay before resuming anticoagulation was significantly shorter for both cesarean (12 vs 33 hours, P=.033) and vaginal deliveries (6 vs 19 hours, P=.006).
32649504	7	6	theme	median	1459:1464	arg1	shorter					1522:1528	shorter	1522:1528	shorter	1522:1528	When comparing cases associated with and without complications, the median delay before resuming anticoagulation was significantly shorter for both cesarean (12 vs 33 hours, P=.033) and vaginal deliveries (6 vs 19 hours, P=.006).
32649504	5	7	theme	intensive	1023:1031	arg1	unit					1038:1041	intensive care unit	1023:1041	intensive care unit	1023:1041	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	9	8	dep	62	1903:1904	arg1	%					1910:1910	9.7%	1907:1910	9.7%	1907:1910	For cesarean deliveries, 7 of 21 (33.3%) of women experienced complications compared with 6 of 62 (9.7%) if anticoagulation was started before or after 15.1 hours, respectively.
32649504	11	9	theme	postpartum	2085:2094	arg1	women					2096:2100	postpartum women	2085:2100	postpartum women who received early therapeutic anticoagulation	2085:2147	CONCLUSION Among postpartum women who received early therapeutic anticoagulation, major complications occurred in 8.4% for cesarean deliveries and 6.0% for vaginal deliveries.
32649504	0	10	from	Evaluation	0:9	arg1	Women					42:46	Postpartum Women	31:46	Postpartum Women	31:46	Evaluation of Complications in Postpartum Women Receiving Therapeutic Anticoagulation.
32649504	3	11	dep	complications	465:477	arg1	including					480:488	including	480:488	including the time to therapeutic anticoagulation resumption after delivery	480:554	Secondary outcomes included minor complications, risk factors associated with total complications (including the time to therapeutic anticoagulation resumption after delivery) and recurrent thrombotic events within 6 weeks postpartum.
32649504	11	12	theme	vaginal	2224:2230	arg1	deliveries					2232:2241	vaginal deliveries	2224:2241	vaginal deliveries	2224:2241	CONCLUSION Among postpartum women who received early therapeutic anticoagulation, major complications occurred in 8.4% for cesarean deliveries and 6.0% for vaginal deliveries.
32649504	2	13	theme	wound	359:363	arg1	complications					365:377	wound complications	359:377	wound complications	359:377	METHODS A multicenter retrospective cohort study was done to evaluate the association between therapeutic anticoagulation postpartum and major complications (hemorrhagic and wound complications).
32649504	11	14	theme	cesarean	2191:2198	arg1	deliveries					2200:2209	cesarean deliveries	2191:2209	cesarean deliveries	2191:2209	CONCLUSION Among postpartum women who received early therapeutic anticoagulation, major complications occurred in 8.4% for cesarean deliveries and 6.0% for vaginal deliveries.
32649504	4	15	theme	therapeutic	683:693	arg1	anticoagulation					695:709	therapeutic anticoagulation	683:709	therapeutic anticoagulation	683:709	RESULTS From 2003 to 2015, 232 consecutive women were treated with therapeutic anticoagulation within 96 hours postpartum; among those treated, 91 received unfractionated heparin, 138 received low-molecular-weight heparin, and three received other anticoagulants.
32649504	2	16	theme	multicenter	195:205	arg1	study					228:232	A multicenter retrospective cohort study	193:232	A multicenter retrospective cohort study	193:232	METHODS A multicenter retrospective cohort study was done to evaluate the association between therapeutic anticoagulation postpartum and major complications (hemorrhagic and wound complications).
32649504	10	17	theme	weeks	2050:2054	arg1	postpartum					2056:2065	6 weeks postpartum	2048:2065	6 weeks postpartum	2048:2065	Two (0.9%) episodes of venous thromboembolism occurred within 6 weeks postpartum.
32649504	5	18	theme	complications	1072:1084	arg1	complications					1072:1084	major wound complications	1060:1084	major wound complications	1060:1084	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	5	18	theme	complications	1072:1084	arg1	outcome					892:898	The primary outcome	880:898	The primary outcome	880:898	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	5	18	theme	complications	1072:1084	arg1	composite					903:911	a composite	901:911	a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications	901:1084	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	5	18	theme	complications	1072:1084	arg1	complications					934:946	major hemorrhagic complications	916:946	major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery)	916:1054	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	11	19	theme	early	2115:2119	arg1	anticoagulation					2133:2147	early therapeutic anticoagulation	2115:2147	early therapeutic anticoagulation	2115:2147	CONCLUSION Among postpartum women who received early therapeutic anticoagulation, major complications occurred in 8.4% for cesarean deliveries and 6.0% for vaginal deliveries.
32649504	4	20	theme	low-molecular-weight	809:828	arg1	heparin					830:836	low-molecular-weight heparin	809:836	low-molecular-weight heparin	809:836	RESULTS From 2003 to 2015, 232 consecutive women were treated with therapeutic anticoagulation within 96 hours postpartum; among those treated, 91 received unfractionated heparin, 138 received low-molecular-weight heparin, and three received other anticoagulants.
32649504	12	21	theme	anticoagulation	2313:2327	arg1	resumption					2287:2296	earlier resumption	2279:2296	earlier resumption of therapeutic anticoagulation	2279:2327	Complications were associated with earlier resumption of therapeutic anticoagulation, particularly before 9.25 hours for vaginal deliveries and before 15.1 hours for cesarean deliveries.
32649504	5	22	dep	83	1104:1105	arg1	%					1111:1111	8.4%	1108:1111	8.4%	1108:1111	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	6	23	dep	83	1293:1294	arg1	%					1301:1301	15.7%	1297:1301	15.7%	1297:1301	Total complications (including major and minor hemorrhagic and wound complications) occurred in 13 of 83 (15.7%) for cesarean deliveries compared with 9 of 149 (6.0%) for vaginal deliveries (P=.016).
32649504	3	24	theme	therapeutic	502:512	arg1	resumption					530:539	therapeutic anticoagulation resumption	502:539	therapeutic anticoagulation resumption after delivery	502:554	Secondary outcomes included minor complications, risk factors associated with total complications (including the time to therapeutic anticoagulation resumption after delivery) and recurrent thrombotic events within 6 weeks postpartum.
32649504	3	25	theme	risk	430:433	arg1	factors					435:441	risk factors	430:441	risk factors associated with total complications (including the time to therapeutic anticoagulation resumption after delivery)	430:555	Secondary outcomes included minor complications, risk factors associated with total complications (including the time to therapeutic anticoagulation resumption after delivery) and recurrent thrombotic events within 6 weeks postpartum.
32649504	5	26	theme	vaginal	1162:1168	arg1	deliveries					1170:1179	vaginal deliveries	1162:1179	vaginal deliveries (P=.490)	1162:1188	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	5	26	theme	vaginal	1162:1168	arg1	P=.490					1182:1187	P=.490	1182:1187	P=.490	1182:1187	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	9	27	theme	cesarean	1812:1819	arg1	deliveries					1821:1830	cesarean deliveries	1812:1830	cesarean deliveries	1812:1830	For cesarean deliveries, 7 of 21 (33.3%) of women experienced complications compared with 6 of 62 (9.7%) if anticoagulation was started before or after 15.1 hours, respectively.
32649504	7	28	dep	hours	1605:1609	arg1	P=.006					1612:1617	P=.006	1612:1617	P=.006	1612:1617	When comparing cases associated with and without complications, the median delay before resuming anticoagulation was significantly shorter for both cesarean (12 vs 33 hours, P=.033) and vaginal deliveries (6 vs 19 hours, P=.006).
32649504	6	29	theme	vaginal	1362:1368	arg1	deliveries					1370:1379	vaginal deliveries	1362:1379	vaginal deliveries (P=.016)	1362:1388	Total complications (including major and minor hemorrhagic and wound complications) occurred in 13 of 83 (15.7%) for cesarean deliveries compared with 9 of 149 (6.0%) for vaginal deliveries (P=.016).
32649504	6	29	theme	vaginal	1362:1368	arg1	P=.016					1382:1387	P=.016	1382:1387	P=.016	1382:1387	Total complications (including major and minor hemorrhagic and wound complications) occurred in 13 of 83 (15.7%) for cesarean deliveries compared with 9 of 149 (6.0%) for vaginal deliveries (P=.016).
32649504	12	30	theme	therapeutic	2301:2311	arg1	anticoagulation					2313:2327	therapeutic anticoagulation	2301:2327	therapeutic anticoagulation	2301:2327	Complications were associated with earlier resumption of therapeutic anticoagulation, particularly before 9.25 hours for vaginal deliveries and before 15.1 hours for cesarean deliveries.
32649504	2	31	dep	complications	328:340	arg1	hemorrhagic					343:353	hemorrhagic	343:353	hemorrhagic	343:353	METHODS A multicenter retrospective cohort study was done to evaluate the association between therapeutic anticoagulation postpartum and major complications (hemorrhagic and wound complications).
32649504	2	31	dep	complications	328:340	arg1	complications					365:377	wound complications	359:377	wound complications	359:377	METHODS A multicenter retrospective cohort study was done to evaluate the association between therapeutic anticoagulation postpartum and major complications (hemorrhagic and wound complications).
32649504	5	32	theme	major	916:920	arg1	complications					934:946	major hemorrhagic complications	916:946	major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery)	916:1054	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	2	33	dep	METHODS	185:191	arg1	done					238:241	done	238:241	was done to evaluate the association between therapeutic anticoagulation postpartum and major complications (hemorrhagic and wound complications)	234:378	METHODS A multicenter retrospective cohort study was done to evaluate the association between therapeutic anticoagulation postpartum and major complications (hemorrhagic and wound complications).
32649504	8	34	dep	51	1650:1651	arg1	%					1658:1658	15.7%	1654:1658	15.7%	1654:1658	For vaginal deliveries, 8 of 51 (15.7%) women had complications when anticoagulation was started before 9.25 hours postpartum, compared with 1 of 98 (1.0%) when started after 9.25 hours.
32649504	6	35	theme	Total	1191:1195	arg1	complications					1197:1209	Total complications	1191:1209	Total complications (including major and minor hemorrhagic and wound complications)	1191:1273	Total complications (including major and minor hemorrhagic and wound complications) occurred in 13 of 83 (15.7%) for cesarean deliveries compared with 9 of 149 (6.0%) for vaginal deliveries (P=.016).
32649504	11	36	theme	major	2150:2154	arg1	CONCLUSION					2068:2077	CONCLUSION	2068:2077	CONCLUSION Among postpartum women who received early therapeutic anticoagulation	2068:2147	CONCLUSION Among postpartum women who received early therapeutic anticoagulation, major complications occurred in 8.4% for cesarean deliveries and 6.0% for vaginal deliveries.
32649504	11	36	theme	major	2150:2154	arg1	complications					2156:2168	major complications	2150:2168	major complications occurred in 8.4% for cesarean deliveries and 6.0% for vaginal deliveries	2150:2241	CONCLUSION Among postpartum women who received early therapeutic anticoagulation, major complications occurred in 8.4% for cesarean deliveries and 6.0% for vaginal deliveries.
32649504	3	37	theme	anticoagulation	514:528	arg1	resumption					530:539	therapeutic anticoagulation resumption	502:539	therapeutic anticoagulation resumption after delivery	502:554	Secondary outcomes included minor complications, risk factors associated with total complications (including the time to therapeutic anticoagulation resumption after delivery) and recurrent thrombotic events within 6 weeks postpartum.
32649504	5	38	theme	hemorrhagic	922:932	arg1	complications					934:946	major hemorrhagic complications	916:946	major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery)	916:1054	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	10	39	theme	thromboembolism	2016:2030	arg1	episodes					1997:2004	Two (0.9%) episodes	1986:2004	Two (0.9%) episodes of venous thromboembolism	1986:2030	Two (0.9%) episodes of venous thromboembolism occurred within 6 weeks postpartum.
32649504	10	39	theme	thromboembolism	2016:2030	arg1	%					1994:1994	0.9%	1991:1994	0.9%	1991:1994	Two (0.9%) episodes of venous thromboembolism occurred within 6 weeks postpartum.
32649504	8	40	theme	98	1767:1768	arg1	98					1767:1768	98	1767:1768	98	1767:1768	For vaginal deliveries, 8 of 51 (15.7%) women had complications when anticoagulation was started before 9.25 hours postpartum, compared with 1 of 98 (1.0%) when started after 9.25 hours.
32649504	8	40	theme	98	1767:1768	arg1	%					1774:1774	1.0%	1771:1774	1.0%	1771:1774	For vaginal deliveries, 8 of 51 (15.7%) women had complications when anticoagulation was started before 9.25 hours postpartum, compared with 1 of 98 (1.0%) when started after 9.25 hours.
32649504	8	40	theme	98	1767:1768	arg1	1					1762:1762	1	1762:1762	1	1762:1762	For vaginal deliveries, 8 of 51 (15.7%) women had complications when anticoagulation was started before 9.25 hours postpartum, compared with 1 of 98 (1.0%) when started after 9.25 hours.
32649504	4	41	theme	other	858:862	arg1	anticoagulants					864:877	other anticoagulants	858:877	other anticoagulants	858:877	RESULTS From 2003 to 2015, 232 consecutive women were treated with therapeutic anticoagulation within 96 hours postpartum; among those treated, 91 received unfractionated heparin, 138 received low-molecular-weight heparin, and three received other anticoagulants.
32649504	5	42	theme	wound	1066:1070	arg1	complications					1072:1084	major wound complications	1060:1084	major wound complications	1060:1084	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	0	43	theme	Complications	14:26	arg1	Evaluation					0:9	Evaluation	0:9	Evaluation of Complications in Postpartum Women	0:46	Evaluation of Complications in Postpartum Women Receiving Therapeutic Anticoagulation.
32649504	5	44	theme	major	1060:1064	arg1	complications					1072:1084	major wound complications	1060:1084	major wound complications	1060:1084	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	3	45	theme	recurrent	561:569	arg1	events					582:587	recurrent thrombotic events	561:587	recurrent thrombotic events within 6 weeks postpartum	561:613	Secondary outcomes included minor complications, risk factors associated with total complications (including the time to therapeutic anticoagulation resumption after delivery) and recurrent thrombotic events within 6 weeks postpartum.
32649504	4	46	from	2015	637:640	arg1	women					659:663	232 consecutive women	643:663	232 consecutive women	643:663	RESULTS From 2003 to 2015, 232 consecutive women were treated with therapeutic anticoagulation within 96 hours postpartum; among those treated, 91 received unfractionated heparin, 138 received low-molecular-weight heparin, and three received other anticoagulants.
32649504	4	46	from	2015	637:640	arg1	RESULTS					616:622	RESULTS	616:622	RESULTS From 2003 to 2015	616:640	RESULTS From 2003 to 2015, 232 consecutive women were treated with therapeutic anticoagulation within 96 hours postpartum; among those treated, 91 received unfractionated heparin, 138 received low-molecular-weight heparin, and three received other anticoagulants.
32649504	4	47	theme	consecutive	647:657	arg1	RESULTS					616:622	RESULTS	616:622	RESULTS From 2003 to 2015	616:640	RESULTS From 2003 to 2015, 232 consecutive women were treated with therapeutic anticoagulation within 96 hours postpartum; among those treated, 91 received unfractionated heparin, 138 received low-molecular-weight heparin, and three received other anticoagulants.
32649504	4	47	theme	consecutive	647:657	arg1	women					659:663	232 consecutive women	643:663	232 consecutive women	643:663	RESULTS From 2003 to 2015, 232 consecutive women were treated with therapeutic anticoagulation within 96 hours postpartum; among those treated, 91 received unfractionated heparin, 138 received low-molecular-weight heparin, and three received other anticoagulants.
32649504	2	48	theme	anticoagulation	291:305	arg1	postpartum					307:316	therapeutic anticoagulation postpartum	279:316	therapeutic anticoagulation postpartum	279:316	METHODS A multicenter retrospective cohort study was done to evaluate the association between therapeutic anticoagulation postpartum and major complications (hemorrhagic and wound complications).
32649504	0	49	theme	Postpartum	31:40	arg1	Women					42:46	Postpartum Women	31:46	Postpartum Women	31:46	Evaluation of Complications in Postpartum Women Receiving Therapeutic Anticoagulation.
32649504	5	50	theme	volume	989:994	arg1	resuscitation					996:1008	volume resuscitation	989:1008	volume resuscitation	989:1008	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	2	51	theme	cohort	221:226	arg1	study					228:232	A multicenter retrospective cohort study	193:232	A multicenter retrospective cohort study	193:232	METHODS A multicenter retrospective cohort study was done to evaluate the association between therapeutic anticoagulation postpartum and major complications (hemorrhagic and wound complications).
32649504	2	52	theme	therapeutic	279:289	arg1	postpartum					307:316	therapeutic anticoagulation postpartum	279:316	therapeutic anticoagulation postpartum	279:316	METHODS A multicenter retrospective cohort study was done to evaluate the association between therapeutic anticoagulation postpartum and major complications (hemorrhagic and wound complications).
32649504	6	53	dep	major	1222:1226	arg1	complications					1260:1272	hemorrhagic and wound complications	1238:1272	complications	1260:1272	Total complications (including major and minor hemorrhagic and wound complications) occurred in 13 of 83 (15.7%) for cesarean deliveries compared with 9 of 149 (6.0%) for vaginal deliveries (P=.016).
32649504	0	54	theme	Therapeutic	58:68	arg1	Anticoagulation					70:84	Therapeutic Anticoagulation	58:84	Therapeutic Anticoagulation	58:84	Evaluation of Complications in Postpartum Women Receiving Therapeutic Anticoagulation.
32649504	11	55	theme	therapeutic	2121:2131	arg1	anticoagulation					2133:2147	early therapeutic anticoagulation	2115:2147	early therapeutic anticoagulation	2115:2147	CONCLUSION Among postpartum women who received early therapeutic anticoagulation, major complications occurred in 8.4% for cesarean deliveries and 6.0% for vaginal deliveries.
32649504	5	56	theme	complications	934:946	arg1	complications					1072:1084	major wound complications	1060:1084	major wound complications	1060:1084	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	5	56	theme	complications	934:946	arg1	outcome					892:898	The primary outcome	880:898	The primary outcome	880:898	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	5	56	theme	complications	934:946	arg1	composite					903:911	a composite	901:911	a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications	901:1084	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	5	56	theme	complications	934:946	arg1	complications					934:946	major hemorrhagic complications	916:946	major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery)	916:1054	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	2	57	theme	retrospective	207:219	arg1	study					228:232	A multicenter retrospective cohort study	193:232	A multicenter retrospective cohort study	193:232	METHODS A multicenter retrospective cohort study was done to evaluate the association between therapeutic anticoagulation postpartum and major complications (hemorrhagic and wound complications).
32649504	1	58	theme	early	139:143	arg1	anticoagulation					168:182	early postpartum therapeutic anticoagulation	139:182	early postpartum therapeutic anticoagulation	139:182	OBJECTIVE To evaluate complications associated with early postpartum therapeutic anticoagulation.
32649504	6	59	dep	149	1347:1349	arg1	%					1355:1355	6.0%	1352:1355	6.0%	1352:1355	Total complications (including major and minor hemorrhagic and wound complications) occurred in 13 of 83 (15.7%) for cesarean deliveries compared with 9 of 149 (6.0%) for vaginal deliveries (P=.016).
32649504	7	60	theme	vaginal	1577:1583	arg1	hours					1605:1609	6 vs 19 hours	1597:1609	6 vs 19 hours	1597:1609	When comparing cases associated with and without complications, the median delay before resuming anticoagulation was significantly shorter for both cesarean (12 vs 33 hours, P=.033) and vaginal deliveries (6 vs 19 hours, P=.006).
32649504	7	60	theme	vaginal	1577:1583	arg1	deliveries					1585:1594	vaginal deliveries	1577:1594	vaginal deliveries (6 vs 19 hours, P=.006)	1577:1618	When comparing cases associated with and without complications, the median delay before resuming anticoagulation was significantly shorter for both cesarean (12 vs 33 hours, P=.033) and vaginal deliveries (6 vs 19 hours, P=.006).
32649504	3	61	theme	Secondary	381:389	arg1	outcomes					391:398	Secondary outcomes	381:398	Secondary outcomes	381:398	Secondary outcomes included minor complications, risk factors associated with total complications (including the time to therapeutic anticoagulation resumption after delivery) and recurrent thrombotic events within 6 weeks postpartum.
32649504	1	62	theme	postpartum	145:154	arg1	anticoagulation					168:182	early postpartum therapeutic anticoagulation	139:182	early postpartum therapeutic anticoagulation	139:182	OBJECTIVE To evaluate complications associated with early postpartum therapeutic anticoagulation.
32649504	12	63	theme	vaginal	2365:2371	arg1	deliveries					2373:2382	vaginal deliveries	2365:2382	vaginal deliveries	2365:2382	Complications were associated with earlier resumption of therapeutic anticoagulation, particularly before 9.25 hours for vaginal deliveries and before 15.1 hours for cesarean deliveries.
32649504	9	64	dep	21	1838:1839	arg1	%					1846:1846	33.3%	1842:1846	33.3%	1842:1846	For cesarean deliveries, 7 of 21 (33.3%) of women experienced complications compared with 6 of 62 (9.7%) if anticoagulation was started before or after 15.1 hours, respectively.
32649504	5	65	theme	cesarean	1118:1125	arg1	deliveries					1127:1136	cesarean deliveries	1118:1136	cesarean deliveries	1118:1136	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	6	66	theme	wound	1254:1258	arg1	complications					1260:1272	hemorrhagic and wound complications	1238:1272	complications	1260:1272	Total complications (including major and minor hemorrhagic and wound complications) occurred in 13 of 83 (15.7%) for cesarean deliveries compared with 9 of 149 (6.0%) for vaginal deliveries (P=.016).
32649504	1	67	theme	therapeutic	156:166	arg1	anticoagulation					168:182	early postpartum therapeutic anticoagulation	139:182	early postpartum therapeutic anticoagulation	139:182	OBJECTIVE To evaluate complications associated with early postpartum therapeutic anticoagulation.
32649504	8	68	theme	hours	1730:1734	arg1	postpartum					1736:1745	9.25 hours postpartum	1725:1745	9.25 hours postpartum	1725:1745	For vaginal deliveries, 8 of 51 (15.7%) women had complications when anticoagulation was started before 9.25 hours postpartum, compared with 1 of 98 (1.0%) when started after 9.25 hours.
32649504	5	69	dep	149	1147:1149	arg1	%					1155:1155	6.0%	1152:1155	6.0%	1152:1155	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	6	70	theme	cesarean	1308:1315	arg1	deliveries					1317:1326	cesarean deliveries	1308:1326	cesarean deliveries	1308:1326	Total complications (including major and minor hemorrhagic and wound complications) occurred in 13 of 83 (15.7%) for cesarean deliveries compared with 9 of 149 (6.0%) for vaginal deliveries (P=.016).
32649504	5	71	theme	care	1033:1036	arg1	unit					1038:1041	intensive care unit	1023:1041	intensive care unit	1023:1041	The primary outcome, a composite of major hemorrhagic complications (requiring transfusion, hospitalization, volume resuscitation, transfer to intensive care unit, or surgery) and major wound complications, occurred in 7 of 83 (8.4%) for cesarean deliveries and 9 of 149 (6.0%) for vaginal deliveries (P=.490).
32649504	2	72	theme	major	322:326	arg1	complications					328:340	major complications	322:340	major complications (hemorrhagic and wound complications)	322:378	METHODS A multicenter retrospective cohort study was done to evaluate the association between therapeutic anticoagulation postpartum and major complications (hemorrhagic and wound complications).
32649504	3	73	theme	thrombotic	571:580	arg1	events					582:587	recurrent thrombotic events	561:587	recurrent thrombotic events within 6 weeks postpartum	561:613	Secondary outcomes included minor complications, risk factors associated with total complications (including the time to therapeutic anticoagulation resumption after delivery) and recurrent thrombotic events within 6 weeks postpartum.
32649504	3	74	theme	minor	409:413	arg1	complications					415:427	minor complications	409:427	minor complications	409:427	Secondary outcomes included minor complications, risk factors associated with total complications (including the time to therapeutic anticoagulation resumption after delivery) and recurrent thrombotic events within 6 weeks postpartum.
32649504	7	75	dep	hours	1558:1562	arg1	P=.033					1565:1570	P=.033	1565:1570	P=.033	1565:1570	When comparing cases associated with and without complications, the median delay before resuming anticoagulation was significantly shorter for both cesarean (12 vs 33 hours, P=.033) and vaginal deliveries (6 vs 19 hours, P=.006).
32649504	6	76	theme	hemorrhagic	1238:1248	arg1	complications					1260:1272	hemorrhagic and wound complications	1238:1272	complications	1260:1272	Total complications (including major and minor hemorrhagic and wound complications) occurred in 13 of 83 (15.7%) for cesarean deliveries compared with 9 of 149 (6.0%) for vaginal deliveries (P=.016).
32649504	9	77	theme	women	1852:1856	arg1	women					1852:1856	women	1852:1856	women experienced complications compared with 6 of 62 (9.7%) if anticoagulation	1852:1930	For cesarean deliveries, 7 of 21 (33.3%) of women experienced complications compared with 6 of 62 (9.7%) if anticoagulation was started before or after 15.1 hours, respectively.
32649504	9	77	theme	women	1852:1856	arg1	21					1838:1839	21	1838:1839	21	1838:1839	For cesarean deliveries, 7 of 21 (33.3%) of women experienced complications compared with 6 of 62 (9.7%) if anticoagulation was started before or after 15.1 hours, respectively.
32649504	12	78	theme	cesarean	2410:2417	arg1	deliveries					2419:2428	cesarean deliveries	2410:2428	cesarean deliveries	2410:2428	Complications were associated with earlier resumption of therapeutic anticoagulation, particularly before 9.25 hours for vaginal deliveries and before 15.1 hours for cesarean deliveries.
32649504	4	79	theme	hours	721:725	arg1	postpartum					727:736	96 hours postpartum	718:736	96 hours postpartum	718:736	RESULTS From 2003 to 2015, 232 consecutive women were treated with therapeutic anticoagulation within 96 hours postpartum; among those treated, 91 received unfractionated heparin, 138 received low-molecular-weight heparin, and three received other anticoagulants.
32649504	4	80	dep	2015	637:640	arg1	to					634:635	to	634:635	to	634:635	RESULTS From 2003 to 2015, 232 consecutive women were treated with therapeutic anticoagulation within 96 hours postpartum; among those treated, 91 received unfractionated heparin, 138 received low-molecular-weight heparin, and three received other anticoagulants.
32649504	3	81	theme	total	459:463	arg1	complications					465:477	total complications	459:477	total complications (including the time to therapeutic anticoagulation resumption after delivery)	459:555	Secondary outcomes included minor complications, risk factors associated with total complications (including the time to therapeutic anticoagulation resumption after delivery) and recurrent thrombotic events within 6 weeks postpartum.
32649504	6	82	dep	complications	1197:1209	arg1	including					1212:1220	including	1212:1220	including major and minor hemorrhagic and wound complications	1212:1272	Total complications (including major and minor hemorrhagic and wound complications) occurred in 13 of 83 (15.7%) for cesarean deliveries compared with 9 of 149 (6.0%) for vaginal deliveries (P=.016).
32649504	4	83	theme	unfractionated	772:785	arg1	heparin					787:793	unfractionated heparin	772:793	unfractionated heparin	772:793	RESULTS From 2003 to 2015, 232 consecutive women were treated with therapeutic anticoagulation within 96 hours postpartum; among those treated, 91 received unfractionated heparin, 138 received low-molecular-weight heparin, and three received other anticoagulants.
32068776	2	0	theme	child	337:341	arg1	growth					343:348	child growth	337:348	child growth	337:348	However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.
32068776	9	1	theme	child	1333:1337	arg1	height					1339:1344	child height	1333:1344	child height	1333:1344	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	12	2	theme	prepregnancy	1873:1884	arg1	BMI					1886:1888	maternal prepregnancy BMI	1864:1888	maternal prepregnancy BMI	1864:1888	Furthermore, altered HMO composition may mediate the impact of maternal prepregnancy BMI on childhood obesity, which warrants further investigation to establish the cause-and-effect relation.
32068776	8	3	from	y	1117:1117	arg1	children					1130:1137	children	1130:1137	children of secretor mothers	1130:1157	RESULTS Maternal HMO composition 3 mo after delivery was associated with height and weight during the first 5 y of life in children of secretor mothers.
32068776	11	4	theme	maternal	1570:1577	arg1	composition					1583:1593	maternal HMO composition	1570:1593	maternal HMO composition	1570:1593	CONCLUSIONS The association between maternal HMO composition and childhood growth may imply a causal relation, which warrants additional testing in preclinical and clinical studies, especially since 2'FL and LNnT are among the HMOs now being added to infant formula.
32068776	8	5	theme	5	1115:1115	arg1	y					1117:1117	the first 5 y	1105:1117	the first 5 y of life in children of secretor mothers	1105:1157	RESULTS Maternal HMO composition 3 mo after delivery was associated with height and weight during the first 5 y of life in children of secretor mothers.
32068776	1	6	theme	infant	127:132	arg1	growth					134:139	infant growth	127:139	infant growth	127:139	BACKGROUND Breastfeeding modulates infant growth and protects against the development of obesity.
32068776	5	7	theme	milk	615:618	arg1	samples					620:626	Human milk samples	609:626	Human milk samples from 802 mothers	609:643	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	2	8	theme	human	267:271	arg1	oligosaccharides					278:293	human milk oligosaccharides	267:293	human milk oligosaccharides (HMOs)	267:300	However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.
32068776	2	8	theme	human	267:271	arg1	HMOs					296:299	HMOs	296:299	HMOs	296:299	However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.
32068776	9	9	theme	z	1357:1357	arg1	scores					1359:1364	z scores	1357:1364	z scores	1357:1364	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	10	10	theme	prepregnancy	1480:1491	arg1	BMI					1493:1495	Maternal prepregnancy BMI	1471:1495	Maternal prepregnancy BMI	1471:1495	Maternal prepregnancy BMI was associated with HMO composition.
32068776	5	11	theme	cohort	701:706	arg1	Steps					715:719	Steps	715:719	Steps to healthy development of Children (STEPS)	715:762	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	5	11	theme	cohort	701:706	arg1	study					708:712	a prospective population-based birth cohort study	664:712	a prospective population-based birth cohort study	664:712	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	12	12	theme	HMO	1822:1824	arg1	composition					1826:1836	altered HMO composition	1814:1836	altered HMO composition	1814:1836	Furthermore, altered HMO composition may mediate the impact of maternal prepregnancy BMI on childhood obesity, which warrants further investigation to establish the cause-and-effect relation.
32068776	2	13	theme	human	236:240	arg1	oligosaccharides					278:293	human milk oligosaccharides	267:293	human milk oligosaccharides (HMOs)	267:300	However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.
32068776	2	13	theme	human	236:240	arg1	components					247:256	human milk components	236:256	human milk components	236:256	However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.
32068776	7	14	theme	HMO	960:962	arg1	data					976:979	maternal HMO composition data	951:979	maternal HMO composition data	951:979	Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.
32068776	8	15	theme	mothers	1151:1157	arg1	children					1130:1137	children	1130:1137	children of secretor mothers	1130:1157	RESULTS Maternal HMO composition 3 mo after delivery was associated with height and weight during the first 5 y of life in children of secretor mothers.
32068776	7	16	from	mo	879:880	arg1	data					867:870	Child growth data	854:870	Child growth data from 3 mo to 5 y	854:887	Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.
32068776	9	17	theme	prepregnancy	1399:1410	arg1	BMI					1412:1414	maternal prepregnancy BMI	1390:1414	maternal prepregnancy BMI	1390:1414	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	5	18	theme	population-based	678:693	arg1	Steps					715:719	Steps	715:719	Steps to healthy development of Children (STEPS)	715:762	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	5	18	theme	population-based	678:693	arg1	study					708:712	a prospective population-based birth cohort study	664:712	a prospective population-based birth cohort study	664:712	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	7	19	attach	linked	941:946	arg2	data					867:870	Child growth data	854:870	Child growth data from 3 mo to 5 y	854:887	Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.
32068776	7	19	attach	linked	941:946	arg1	data					976:979	maternal HMO composition data	951:979	maternal HMO composition data	951:979	Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.
32068776	12	20	theme	further	1927:1933	arg1	investigation					1935:1947	further investigation	1927:1947	further investigation	1927:1947	Furthermore, altered HMO composition may mediate the impact of maternal prepregnancy BMI on childhood obesity, which warrants further investigation to establish the cause-and-effect relation.
32068776	5	21	theme	Children	747:754	arg1	development					732:742	healthy development	724:742	healthy development of Children (STEPS)	724:762	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	7	22	theme	well-baby	919:927	arg1	clinics					929:935	municipal well-baby clinics	909:935	municipal well-baby clinics	909:935	Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.
32068776	0	23	theme	early	75:79	arg1	childhood					81:89	early childhood	75:89	early childhood	75:89	Associations between human milk oligosaccharides and growth in infancy and early childhood.
32068776	11	24	theme	additional	1660:1669	arg1	testing					1671:1677	additional testing	1660:1677	additional testing	1660:1677	CONCLUSIONS The association between maternal HMO composition and childhood growth may imply a causal relation, which warrants additional testing in preclinical and clinical studies, especially since 2'FL and LNnT are among the HMOs now being added to infant formula.
32068776	9	25	theme	z	1447:1447	arg1	score					1449:1453	birthweight z score	1435:1453	birthweight z score	1435:1453	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	0	26	from	growth	53:58	arg1	infancy					63:69	infancy	63:69	infancy	63:69	Associations between human milk oligosaccharides and growth in infancy and early childhood.
32068776	0	26	from	growth	53:58	arg1	childhood					81:89	early childhood	75:89	early childhood	75:89	Associations between human milk oligosaccharides and growth in infancy and early childhood.
32068776	3	27	theme	maternal	432:439	arg1	composition					445:455	maternal HMO composition	432:455	maternal HMO composition	432:455	OBJECTIVE Our objective was to determine the association between maternal HMO composition and child growth during the first 5 y of life.
32068776	0	28	from	oligosaccharides	32:47	arg1	infancy					63:69	infancy	63:69	infancy	63:69	Associations between human milk oligosaccharides and growth in infancy and early childhood.
32068776	0	28	from	oligosaccharides	32:47	arg1	childhood					81:89	early childhood	75:89	early childhood	75:89	Associations between human milk oligosaccharides and growth in infancy and early childhood.
32068776	1	29	theme	BACKGROUND	92:101	arg1	Breastfeeding					103:115	BACKGROUND Breastfeeding	92:115	BACKGROUND Breastfeeding	92:115	BACKGROUND Breastfeeding modulates infant growth and protects against the development of obesity.
32068776	3	30	theme	child	461:465	arg1	growth					467:472	child growth	461:472	child growth	461:472	OBJECTIVE Our objective was to determine the association between maternal HMO composition and child growth during the first 5 y of life.
32068776	0	31	theme	human	21:25	arg1	oligosaccharides					32:47	human milk oligosaccharides	21:47	human milk oligosaccharides	21:47	Associations between human milk oligosaccharides and growth in infancy and early childhood.
32068776	11	32	dep	CONCLUSIONS	1534:1544	arg1	imply					1620:1624	imply	1620:1624	may imply a causal relation, which warrants additional testing in preclinical and clinical studies, especially since 2'FL and LNnT are among the HMOs now being added to infant formula	1616:1798	CONCLUSIONS The association between maternal HMO composition and childhood growth may imply a causal relation, which warrants additional testing in preclinical and clinical studies, especially since 2'FL and LNnT are among the HMOs now being added to infant formula.
32068776	8	33	theme	HMO	1024:1026	arg1	composition					1028:1038	Maternal HMO composition	1015:1038	Maternal HMO composition 3 mo after delivery	1015:1058	RESULTS Maternal HMO composition 3 mo after delivery was associated with height and weight during the first 5 y of life in children of secretor mothers.
32068776	4	34	theme	maternal	541:548	arg1	BMI					563:565	maternal prepregnancy BMI	541:565	maternal prepregnancy BMI	541:565	In addition, the association between maternal prepregnancy BMI and HMO composition was assessed.
32068776	3	35	theme	first	485:489	arg1	y					493:493	the first 5 y	481:493	the first 5 y of life	481:501	OBJECTIVE Our objective was to determine the association between maternal HMO composition and child growth during the first 5 y of life.
32068776	11	36	theme	causal	1628:1633	arg1	relation					1635:1642	a causal relation	1626:1642	a causal relation	1626:1642	CONCLUSIONS The association between maternal HMO composition and childhood growth may imply a causal relation, which warrants additional testing in preclinical and clinical studies, especially since 2'FL and LNnT are among the HMOs now being added to infant formula.
32068776	3	37	theme	life	498:501	arg1	y					493:493	the first 5 y	481:493	the first 5 y of life	481:501	OBJECTIVE Our objective was to determine the association between maternal HMO composition and child growth during the first 5 y of life.
32068776	12	38	theme	childhood	1893:1901	arg1	obesity					1903:1909	childhood obesity	1893:1909	childhood obesity	1893:1909	Furthermore, altered HMO composition may mediate the impact of maternal prepregnancy BMI on childhood obesity, which warrants further investigation to establish the cause-and-effect relation.
32068776	5	39	theme	802	633:635	arg1	mothers					637:643	802 mothers	633:643	802 mothers	633:643	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	2	40	theme	growth	343:348	arg1	programming					322:332	programming	322:332	programming of child growth	322:348	However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.
32068776	7	41	theme	Child	854:858	arg1	data					867:870	Child growth data	854:870	Child growth data from 3 mo to 5 y	854:887	Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.
32068776	12	42	theme	maternal	1864:1871	arg1	BMI					1886:1888	maternal prepregnancy BMI	1864:1888	maternal prepregnancy BMI	1864:1888	Furthermore, altered HMO composition may mediate the impact of maternal prepregnancy BMI on childhood obesity, which warrants further investigation to establish the cause-and-effect relation.
32068776	4	43	theme	HMO	571:573	arg1	composition					575:585	HMO composition	571:585	HMO composition	571:585	In addition, the association between maternal prepregnancy BMI and HMO composition was assessed.
32068776	11	44	theme	HMO	1579:1581	arg1	composition					1583:1593	maternal HMO composition	1570:1593	maternal HMO composition	1570:1593	CONCLUSIONS The association between maternal HMO composition and childhood growth may imply a causal relation, which warrants additional testing in preclinical and clinical studies, especially since 2'FL and LNnT are among the HMOs now being added to infant formula.
32068776	5	45	theme	Human	609:613	arg1	samples					620:626	Human milk samples	609:626	Human milk samples from 802 mothers	609:643	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	2	46	theme	milk	273:276	arg1	oligosaccharides					278:293	human milk oligosaccharides	267:293	human milk oligosaccharides (HMOs)	267:300	However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.
32068776	2	46	theme	milk	273:276	arg1	HMOs					296:299	HMOs	296:299	HMOs	296:299	However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.
32068776	1	47	theme	obesity	181:187	arg1	development					166:176	the development	162:176	the development of obesity	162:187	BACKGROUND Breastfeeding modulates infant growth and protects against the development of obesity.
32068776	12	48	theme	BMI	1886:1888	arg1	impact					1854:1859	the impact	1850:1859	the impact of maternal prepregnancy BMI on childhood obesity, which warrants further investigation to establish the cause-and-effect relation	1850:1990	Furthermore, altered HMO composition may mediate the impact of maternal prepregnancy BMI on childhood obesity, which warrants further investigation to establish the cause-and-effect relation.
32068776	10	49	theme	Maternal	1471:1478	arg1	BMI					1493:1495	Maternal prepregnancy BMI	1471:1495	Maternal prepregnancy BMI	1471:1495	Maternal prepregnancy BMI was associated with HMO composition.
32068776	5	50	theme	birth	695:699	arg1	Steps					715:719	Steps	715:719	Steps to healthy development of Children (STEPS)	715:762	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	5	50	theme	birth	695:699	arg1	study					708:712	a prospective population-based birth cohort study	664:712	a prospective population-based birth cohort study	664:712	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	8	51	theme	life	1122:1125	arg1	y					1117:1117	the first 5 y	1105:1117	the first 5 y of life in children of secretor mothers	1105:1157	RESULTS Maternal HMO composition 3 mo after delivery was associated with height and weight during the first 5 y of life in children of secretor mothers.
32068776	6	52	from	composition	798:808	arg1	samples					824:830	these milk samples	813:830	these milk samples	813:830	HMO composition in these milk samples was analyzed by HPLC.
32068776	11	53	theme	clinical	1698:1705	arg1	studies					1707:1713	preclinical and clinical studies	1682:1713	preclinical and clinical studies	1682:1713	CONCLUSIONS The association between maternal HMO composition and childhood growth may imply a causal relation, which warrants additional testing in preclinical and clinical studies, especially since 2'FL and LNnT are among the HMOs now being added to infant formula.
32068776	2	54	theme	milk	242:245	arg1	oligosaccharides					278:293	human milk oligosaccharides	267:293	human milk oligosaccharides (HMOs)	267:300	However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.
32068776	2	54	theme	milk	242:245	arg1	components					247:256	human milk components	236:256	human milk components	236:256	However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.
32068776	12	55	theme	altered	1814:1820	arg1	composition					1826:1836	altered HMO composition	1814:1836	altered HMO composition	1814:1836	Furthermore, altered HMO composition may mediate the impact of maternal prepregnancy BMI on childhood obesity, which warrants further investigation to establish the cause-and-effect relation.
32068776	9	56	theme	HMO	1174:1176	arg1	diversity					1178:1186	HMO diversity	1174:1186	HMO diversity	1174:1186	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	7	57	theme	composition	964:974	arg1	data					976:979	maternal HMO composition data	951:979	maternal HMO composition data	951:979	Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.
32068776	9	58	theme	maternal	1390:1397	arg1	BMI					1412:1414	maternal prepregnancy BMI	1390:1414	maternal prepregnancy BMI	1390:1414	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	8	59	theme	secretor	1142:1149	arg1	mothers					1151:1157	secretor mothers	1142:1157	secretor mothers	1142:1157	RESULTS Maternal HMO composition 3 mo after delivery was associated with height and weight during the first 5 y of life in children of secretor mothers.
32068776	9	60	dep	height	1339:1344	arg1	scores					1359:1364	z scores	1357:1364	z scores	1357:1364	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	5	61	theme	prospective	666:676	arg1	Steps					715:719	Steps	715:719	Steps to healthy development of Children (STEPS)	715:762	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	5	61	theme	prospective	666:676	arg1	study					708:712	a prospective population-based birth cohort study	664:712	a prospective population-based birth cohort study	664:712	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	7	62	theme	maternal	951:958	arg1	data					976:979	maternal HMO composition data	951:979	maternal HMO composition data	951:979	Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.
32068776	12	63	theme	cause-and-effect	1966:1981	arg1	relation					1983:1990	the cause-and-effect relation	1962:1990	the cause-and-effect relation	1962:1990	Furthermore, altered HMO composition may mediate the impact of maternal prepregnancy BMI on childhood obesity, which warrants further investigation to establish the cause-and-effect relation.
32068776	7	64	dep	mo	879:880	arg1	y					887:887	5 y	885:887	3 mo to 5 y	877:887	Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.
32068776	7	64	dep	mo	879:880	arg1	to					882:883	to	882:883	to	882:883	Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.
32068776	9	65	theme	lacto-N-neo-tetraose	1213:1232	arg1	LNnT					1235:1238	LNnT	1235:1238	LNnT	1235:1238	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	9	65	theme	lacto-N-neo-tetraose	1213:1232	arg1	diversity					1178:1186	HMO diversity	1174:1186	HMO diversity	1174:1186	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	9	65	theme	lacto-N-neo-tetraose	1213:1232	arg1	concentration					1196:1208	the concentration	1192:1208	the concentration of lacto-N-neo-tetraose (LNnT)	1192:1239	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	9	66	theme	delivery	1425:1432	arg1	BMI					1412:1414	maternal prepregnancy BMI	1390:1414	maternal prepregnancy BMI	1390:1414	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	9	66	theme	delivery	1425:1432	arg1	score					1449:1453	birthweight z score	1435:1453	birthweight z score	1435:1453	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	9	66	theme	delivery	1425:1432	arg1	sex					1456:1458	sex	1456:1458	sex	1456:1458	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	9	66	theme	delivery	1425:1432	arg1	mode					1417:1420	mode	1417:1420	mode of delivery	1417:1432	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	9	66	theme	delivery	1425:1432	arg1	time					1465:1468	time	1465:1468	time	1465:1468	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	3	67	dep	OBJECTIVE	367:375	arg1	was					391:393	was	391:393	was to determine the association between maternal HMO composition and child growth during the first 5 y of life	391:501	OBJECTIVE Our objective was to determine the association between maternal HMO composition and child growth during the first 5 y of life.
32068776	11	68	theme	preclinical	1682:1692	arg1	studies					1707:1713	preclinical and clinical studies	1682:1713	preclinical and clinical studies	1682:1713	CONCLUSIONS The association between maternal HMO composition and childhood growth may imply a causal relation, which warrants additional testing in preclinical and clinical studies, especially since 2'FL and LNnT are among the HMOs now being added to infant formula.
32068776	7	69	theme	municipal	909:917	arg1	clinics					929:935	municipal well-baby clinics	909:935	municipal well-baby clinics	909:935	Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.
32068776	9	70	theme	birthweight	1435:1445	arg1	score					1449:1453	birthweight z score	1435:1453	birthweight z score	1435:1453	Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time.
32068776	5	71	theme	healthy	724:730	arg1	development					732:742	healthy development	724:742	healthy development of Children (STEPS)	724:762	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	2	72	from	variation	223:231	arg1	oligosaccharides					278:293	human milk oligosaccharides	267:293	human milk oligosaccharides (HMOs)	267:300	However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.
32068776	2	72	from	variation	223:231	arg1	components					247:256	human milk components	236:256	human milk components	236:256	However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.
32068776	8	73	dep	mo	1042:1043	arg1	delivery					1051:1058	delivery	1051:1058	delivery	1051:1058	RESULTS Maternal HMO composition 3 mo after delivery was associated with height and weight during the first 5 y of life in children of secretor mothers.
32068776	3	74	theme	HMO	441:443	arg1	composition					445:455	maternal HMO composition	432:455	maternal HMO composition	432:455	OBJECTIVE Our objective was to determine the association between maternal HMO composition and child growth during the first 5 y of life.
32068776	8	75	theme	Maternal	1015:1022	arg1	composition					1028:1038	Maternal HMO composition	1015:1038	Maternal HMO composition 3 mo after delivery	1015:1058	RESULTS Maternal HMO composition 3 mo after delivery was associated with height and weight during the first 5 y of life in children of secretor mothers.
32068776	0	76	theme	milk	27:30	arg1	oligosaccharides					32:47	human milk oligosaccharides	21:47	human milk oligosaccharides	21:47	Associations between human milk oligosaccharides and growth in infancy and early childhood.
32068776	4	77	theme	prepregnancy	550:561	arg1	BMI					563:565	maternal prepregnancy BMI	541:565	maternal prepregnancy BMI	541:565	In addition, the association between maternal prepregnancy BMI and HMO composition was assessed.
32068776	11	78	theme	childhood	1599:1607	arg1	growth					1609:1614	childhood growth	1599:1614	childhood growth	1599:1614	CONCLUSIONS The association between maternal HMO composition and childhood growth may imply a causal relation, which warrants additional testing in preclinical and clinical studies, especially since 2'FL and LNnT are among the HMOs now being added to infant formula.
32068776	12	79	from	impact	1854:1859	arg1	obesity					1903:1909	childhood obesity	1893:1909	childhood obesity	1893:1909	Furthermore, altered HMO composition may mediate the impact of maternal prepregnancy BMI on childhood obesity, which warrants further investigation to establish the cause-and-effect relation.
32068776	6	80	theme	milk	819:822	arg1	samples					824:830	these milk samples	813:830	these milk samples	813:830	HMO composition in these milk samples was analyzed by HPLC.
32068776	2	81	theme	maternal	214:221	arg1	variation					223:231	maternal variation	214:231	maternal variation in human milk components, such as human milk oligosaccharides (HMOs),	214:301	However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.
32068776	5	82	from	mothers	637:643	arg1	samples					620:626	Human milk samples	609:626	Human milk samples from 802 mothers	609:643	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	10	83	theme	HMO	1517:1519	arg1	composition					1521:1531	HMO composition	1517:1531	HMO composition	1517:1531	Maternal prepregnancy BMI was associated with HMO composition.
32068776	5	84	dep	METHODS	601:607	arg1	obtained					650:657	obtained	650:657	were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland	645:791	METHODS Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland.
32068776	7	85	theme	growth	860:865	arg1	data					867:870	Child growth data	854:870	Child growth data from 3 mo to 5 y	854:887	Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.
32068776	6	86	theme	HMO	794:796	arg1	composition					798:808	HMO composition	794:808	HMO composition in these milk samples	794:830	HMO composition in these milk samples was analyzed by HPLC.
32068776	11	87	theme	infant	1785:1790	arg1	formula					1792:1798	infant formula	1785:1798	infant formula	1785:1798	CONCLUSIONS The association between maternal HMO composition and childhood growth may imply a causal relation, which warrants additional testing in preclinical and clinical studies, especially since 2'FL and LNnT are among the HMOs now being added to infant formula.
32068776	8	88	dep	RESULTS	1007:1013	arg1	associated					1064:1073	associated	1064:1073	was associated with height and weight during the first 5 y of life in children of secretor mothers	1060:1157	RESULTS Maternal HMO composition 3 mo after delivery was associated with height and weight during the first 5 y of life in children of secretor mothers.
32824621	2	0	theme	casted	445:450	arg1	films					452:456	casted films	445:456	casted films presenting a smooth non porous structure	445:497	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	5	1	theme	confocal	1016:1023	arg1	imaging					1038:1044	confocal fluorescence imaging	1016:1044	confocal fluorescence imaging	1016:1044	Reaction of the loaded rhodamine B hydrazide with Cu(II) was confirmed by absorption and emission spectroscopies and by confocal fluorescence imaging, through detection of the product rhodamine B.
32824621	3	2	from	stability	620:628	arg1	materials					658:666	the polymeric materials	644:666	the polymeric materials	644:666	Loading of rhodamine B hydrazide on the fabrics after their production was found to be the best procedure to ensure the stability of the dye in the polymeric materials.
32824621	5	3	theme	fluorescence	1025:1036	arg1	imaging					1038:1044	confocal fluorescence imaging	1016:1044	confocal fluorescence imaging	1016:1044	Reaction of the loaded rhodamine B hydrazide with Cu(II) was confirmed by absorption and emission spectroscopies and by confocal fluorescence imaging, through detection of the product rhodamine B.
32824621	3	4	from	Loading	500:506	arg1	fabrics					540:546	the fabrics	536:546	the fabrics after their production	536:569	Loading of rhodamine B hydrazide on the fabrics after their production was found to be the best procedure to ensure the stability of the dye in the polymeric materials.
32824621	1	5	theme	Cu	215:216	arg1	sensor					230:235	Cu(II) optical sensor	215:235	Cu(II) optical sensor	215:235	In this work, different materials were fabricated from cellulose acetate, loaded with rhodamine B hydrazide and tested as Cu(II) optical sensor.
32824621	1	5	theme	Cu	215:216	arg1	materials					117:125	different materials	107:125	different materials	107:125	In this work, different materials were fabricated from cellulose acetate, loaded with rhodamine B hydrazide and tested as Cu(II) optical sensor.
32824621	2	6	theme	porous	482:487	arg1	structure					489:497	a smooth non porous structure	469:497	a smooth non porous structure	469:497	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	5	7	theme	hydrazide	931:939	arg1	Reaction					896:903	Reaction	896:903	Reaction of the loaded rhodamine B hydrazide with Cu(II)	896:951	Reaction of the loaded rhodamine B hydrazide with Cu(II) was confirmed by absorption and emission spectroscopies and by confocal fluorescence imaging, through detection of the product rhodamine B.
32824621	4	8	theme	emission	684:691	arg1	analysis					693:700	Absorption and emission analysis	669:700	Absorption and emission analysis of the solid substrates	669:724	Absorption and emission analysis of the solid substrates revealed the presence of the dye on the porous fabrics and allowed to choose the most suited materials and loading conditions to test their response towards Cu(II) ions.
32824621	4	9	attach	presence	739:746	arg2	dye					755:757	the dye	751:757	the dye	751:757	Absorption and emission analysis of the solid substrates revealed the presence of the dye on the porous fabrics and allowed to choose the most suited materials and loading conditions to test their response towards Cu(II) ions.
32824621	4	9	attach	presence	739:746	arg1	fabrics					773:779	the porous fabrics	762:779	the porous fabrics	762:779	Absorption and emission analysis of the solid substrates revealed the presence of the dye on the porous fabrics and allowed to choose the most suited materials and loading conditions to test their response towards Cu(II) ions.
32824621	0	10	theme	Cu	85:86	arg1	Detection					72:80	Optical Detection	64:80	Optical Detection of Cu(II)	64:90	Cellulose Acetate Fabrics Loaded with Rhodamine B Hydrazide for Optical Detection of Cu(II).
32824621	6	11	theme	materials	1171:1179	arg1	applications					1132:1143	promising sensing applications	1114:1143	promising sensing applications of the prepared composite materials	1114:1179	The results point to promising sensing applications of the prepared composite materials.
32824621	2	12	theme	smooth	471:476	arg1	structure					489:497	a smooth non porous structure	469:497	a smooth non porous structure	469:497	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	2	13	with	fibers	350:355	arg1	diameter					370:377	varying diameter	362:377	varying diameter depending on the preparation procedure using electrospinning	362:438	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	6	14	theme	composite	1161:1169	arg1	materials					1171:1179	the prepared composite materials	1148:1179	the prepared composite materials	1148:1179	The results point to promising sensing applications of the prepared composite materials.
32824621	4	15	theme	substrates	715:724	arg1	analysis					693:700	Absorption and emission analysis	669:700	Absorption and emission analysis of the solid substrates	669:724	Absorption and emission analysis of the solid substrates revealed the presence of the dye on the porous fabrics and allowed to choose the most suited materials and loading conditions to test their response towards Cu(II) ions.
32824621	4	16	theme	Cu	883:884	arg1	ions					890:893	Cu(II) ions	883:893	Cu(II) ions	883:893	Absorption and emission analysis of the solid substrates revealed the presence of the dye on the porous fabrics and allowed to choose the most suited materials and loading conditions to test their response towards Cu(II) ions.
32824621	4	17	theme	porous	766:771	arg1	fabrics					773:779	the porous fabrics	762:779	the porous fabrics	762:779	Absorption and emission analysis of the solid substrates revealed the presence of the dye on the porous fabrics and allowed to choose the most suited materials and loading conditions to test their response towards Cu(II) ions.
32824621	4	18	theme	solid	709:713	arg1	substrates					715:724	the solid substrates	705:724	the solid substrates	705:724	Absorption and emission analysis of the solid substrates revealed the presence of the dye on the porous fabrics and allowed to choose the most suited materials and loading conditions to test their response towards Cu(II) ions.
32824621	2	19	theme	preparation	396:406	arg1	procedure					408:416	the preparation procedure	392:416	the preparation procedure using electrospinning	392:438	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	3	20	theme	polymeric	648:656	arg1	materials					658:666	the polymeric materials	644:666	the polymeric materials	644:666	Loading of rhodamine B hydrazide on the fabrics after their production was found to be the best procedure to ensure the stability of the dye in the polymeric materials.
32824621	3	21	theme	hydrazide	523:531	arg1	Loading					500:506	Loading	500:506	Loading of rhodamine B hydrazide on the fabrics after their production	500:569	Loading of rhodamine B hydrazide on the fabrics after their production was found to be the best procedure to ensure the stability of the dye in the polymeric materials.
32824621	3	21	theme	hydrazide	523:531	arg1	procedure					596:604	the best procedure	587:604	the best procedure to ensure the stability of the dye in the polymeric materials	587:666	Loading of rhodamine B hydrazide on the fabrics after their production was found to be the best procedure to ensure the stability of the dye in the polymeric materials.
32824621	5	22	theme	emission	985:992	arg1	spectroscopies					994:1007	emission spectroscopies	985:1007	emission spectroscopies	985:1007	Reaction of the loaded rhodamine B hydrazide with Cu(II) was confirmed by absorption and emission spectroscopies and by confocal fluorescence imaging, through detection of the product rhodamine B.
32824621	1	23	theme	cellulose	148:156	arg1	acetate					158:164	cellulose acetate	148:164	cellulose acetate	148:164	In this work, different materials were fabricated from cellulose acetate, loaded with rhodamine B hydrazide and tested as Cu(II) optical sensor.
32824621	0	24	theme	Cellulose	0:8	arg1	Fabrics					18:24	Cellulose Acetate Fabrics	0:24	Cellulose Acetate Fabrics	0:24	Cellulose Acetate Fabrics Loaded with Rhodamine B Hydrazide for Optical Detection of Cu(II).
32824621	4	25	theme	Absorption	669:678	arg1	analysis					693:700	Absorption and emission analysis	669:700	Absorption and emission analysis of the solid substrates	669:724	Absorption and emission analysis of the solid substrates revealed the presence of the dye on the porous fabrics and allowed to choose the most suited materials and loading conditions to test their response towards Cu(II) ions.
32824621	1	26	theme	optical	222:228	arg1	sensor					230:235	Cu(II) optical sensor	215:235	Cu(II) optical sensor	215:235	In this work, different materials were fabricated from cellulose acetate, loaded with rhodamine B hydrazide and tested as Cu(II) optical sensor.
32824621	1	26	theme	optical	222:228	arg1	materials					117:125	different materials	107:125	different materials	107:125	In this work, different materials were fabricated from cellulose acetate, loaded with rhodamine B hydrazide and tested as Cu(II) optical sensor.
32824621	3	27	theme	rhodamine	511:519	arg1	B					521:521	rhodamine B	511:521	rhodamine B hydrazide	511:531	Loading of rhodamine B hydrazide on the fabrics after their production was found to be the best procedure to ensure the stability of the dye in the polymeric materials.
32824621	5	28	theme	rhodamine	919:927	arg1	hydrazide					931:939	the loaded rhodamine B hydrazide	908:939	the loaded rhodamine B hydrazide	908:939	Reaction of the loaded rhodamine B hydrazide with Cu(II) was confirmed by absorption and emission spectroscopies and by confocal fluorescence imaging, through detection of the product rhodamine B.
32824621	5	29	theme	rhodamine	1080:1088	arg1	B					1090:1090	the product rhodamine B	1068:1090	the product rhodamine B	1068:1090	Reaction of the loaded rhodamine B hydrazide with Cu(II) was confirmed by absorption and emission spectroscopies and by confocal fluorescence imaging, through detection of the product rhodamine B.
32824621	3	30	theme	best	591:594	arg1	Loading					500:506	Loading	500:506	Loading of rhodamine B hydrazide on the fabrics after their production	500:569	Loading of rhodamine B hydrazide on the fabrics after their production was found to be the best procedure to ensure the stability of the dye in the polymeric materials.
32824621	3	30	theme	best	591:594	arg1	procedure					596:604	the best procedure	587:604	the best procedure to ensure the stability of the dye in the polymeric materials	587:666	Loading of rhodamine B hydrazide on the fabrics after their production was found to be the best procedure to ensure the stability of the dye in the polymeric materials.
32824621	3	31	theme	B	521:521	arg1	hydrazide					523:531	rhodamine B hydrazide	511:531	rhodamine B hydrazide	511:531	Loading of rhodamine B hydrazide on the fabrics after their production was found to be the best procedure to ensure the stability of the dye in the polymeric materials.
32824621	2	32	theme	varying	362:368	arg1	diameter					370:377	varying diameter	362:377	varying diameter depending on the preparation procedure using electrospinning	362:438	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	0	33	theme	Rhodamine	38:46	arg1	Hydrazide					50:58	Rhodamine B Hydrazide	38:58	Rhodamine B Hydrazide for Optical Detection of Cu(II)	38:90	Cellulose Acetate Fabrics Loaded with Rhodamine B Hydrazide for Optical Detection of Cu(II).
32824621	5	34	theme	B	1090:1090	arg1	detection					1055:1063	detection	1055:1063	detection of the product rhodamine B	1055:1090	Reaction of the loaded rhodamine B hydrazide with Cu(II) was confirmed by absorption and emission spectroscopies and by confocal fluorescence imaging, through detection of the product rhodamine B.
32824621	6	35	theme	promising	1114:1122	arg1	applications					1132:1143	promising sensing applications	1114:1143	promising sensing applications of the prepared composite materials	1114:1179	The results point to promising sensing applications of the prepared composite materials.
32824621	4	36	theme	dye	755:757	arg1	presence					739:746	the presence	735:746	the presence of the dye on the porous fabrics	735:779	Absorption and emission analysis of the solid substrates revealed the presence of the dye on the porous fabrics and allowed to choose the most suited materials and loading conditions to test their response towards Cu(II) ions.
32824621	5	37	theme	B	929:929	arg1	hydrazide					931:939	the loaded rhodamine B hydrazide	908:939	the loaded rhodamine B hydrazide	908:939	Reaction of the loaded rhodamine B hydrazide with Cu(II) was confirmed by absorption and emission spectroscopies and by confocal fluorescence imaging, through detection of the product rhodamine B.
32824621	1	38	theme	rhodamine	179:187	arg1	hydrazide					191:199	rhodamine B hydrazide	179:199	rhodamine B hydrazide	179:199	In this work, different materials were fabricated from cellulose acetate, loaded with rhodamine B hydrazide and tested as Cu(II) optical sensor.
32824621	5	39	theme	product	1072:1078	arg1	B					1090:1090	the product rhodamine B	1068:1090	the product rhodamine B	1068:1090	Reaction of the loaded rhodamine B hydrazide with Cu(II) was confirmed by absorption and emission spectroscopies and by confocal fluorescence imaging, through detection of the product rhodamine B.
32824621	2	40	theme	non	478:480	arg1	structure					489:497	a smooth non porous structure	469:497	a smooth non porous structure	469:497	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	0	41	theme	B	48:48	arg1	Hydrazide					50:58	Rhodamine B Hydrazide	38:58	Rhodamine B Hydrazide for Optical Detection of Cu(II)	38:90	Cellulose Acetate Fabrics Loaded with Rhodamine B Hydrazide for Optical Detection of Cu(II).
32824621	4	42	theme	suited	812:817	arg1	materials					819:827	materials	819:827	materials	819:827	Absorption and emission analysis of the solid substrates revealed the presence of the dye on the porous fabrics and allowed to choose the most suited materials and loading conditions to test their response towards Cu(II) ions.
32824621	6	43	theme	prepared	1152:1159	arg1	materials					1171:1179	the prepared composite materials	1148:1179	the prepared composite materials	1148:1179	The results point to promising sensing applications of the prepared composite materials.
32824621	2	44	theme	porous	284:289	arg1	structure					291:299	a sub-micron porous structure	271:299	a sub-micron porous structure using the phase inversion technique	271:335	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	4	45	theme	loading	833:839	arg1	conditions					841:850	loading conditions	833:850	loading conditions	833:850	Absorption and emission analysis of the solid substrates revealed the presence of the dye on the porous fabrics and allowed to choose the most suited materials and loading conditions to test their response towards Cu(II) ions.
32824621	6	46	theme	sensing	1124:1130	arg1	applications					1132:1143	promising sensing applications	1114:1143	promising sensing applications of the prepared composite materials	1114:1179	The results point to promising sensing applications of the prepared composite materials.
32824621	2	47	theme	sub-micron	273:282	arg1	structure					291:299	a sub-micron porous structure	271:299	a sub-micron porous structure using the phase inversion technique	271:335	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	1	48	theme	B	189:189	arg1	hydrazide					191:199	rhodamine B hydrazide	179:199	rhodamine B hydrazide	179:199	In this work, different materials were fabricated from cellulose acetate, loaded with rhodamine B hydrazide and tested as Cu(II) optical sensor.
32824621	1	49	theme	different	107:115	arg1	sensor					230:235	Cu(II) optical sensor	215:235	Cu(II) optical sensor	215:235	In this work, different materials were fabricated from cellulose acetate, loaded with rhodamine B hydrazide and tested as Cu(II) optical sensor.
32824621	1	49	theme	different	107:115	arg1	materials					117:125	different materials	107:125	different materials	107:125	In this work, different materials were fabricated from cellulose acetate, loaded with rhodamine B hydrazide and tested as Cu(II) optical sensor.
32824621	0	50	theme	Optical	64:70	arg1	Detection					72:80	Optical Detection	64:80	Optical Detection of Cu(II)	64:90	Cellulose Acetate Fabrics Loaded with Rhodamine B Hydrazide for Optical Detection of Cu(II).
32824621	2	51	theme	fibers	350:355	arg1	films					452:456	casted films	445:456	casted films presenting a smooth non porous structure	445:497	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	2	51	theme	fibers	350:355	arg1	clusters					338:345	clusters	338:345	clusters of fibers with varying diameter depending on the preparation procedure using electrospinning	338:438	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	2	51	theme	fibers	350:355	arg1	membranes					250:258	membranes	250:258	membranes displaying a sub-micron porous structure using the phase inversion technique	250:335	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	4	52	from	presence	739:746	arg1	fabrics					773:779	the porous fabrics	762:779	the porous fabrics	762:779	Absorption and emission analysis of the solid substrates revealed the presence of the dye on the porous fabrics and allowed to choose the most suited materials and loading conditions to test their response towards Cu(II) ions.
32824621	2	53	theme	inversion	317:325	arg1	technique					327:335	the phase inversion technique	307:335	the phase inversion technique	307:335	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	3	54	theme	dye	637:639	arg1	stability					620:628	the stability	616:628	the stability of the dye in the polymeric materials	616:666	Loading of rhodamine B hydrazide on the fabrics after their production was found to be the best procedure to ensure the stability of the dye in the polymeric materials.
32824621	5	55	theme	loaded	912:917	arg1	hydrazide					931:939	the loaded rhodamine B hydrazide	908:939	the loaded rhodamine B hydrazide	908:939	Reaction of the loaded rhodamine B hydrazide with Cu(II) was confirmed by absorption and emission spectroscopies and by confocal fluorescence imaging, through detection of the product rhodamine B.
32824621	2	56	theme	phase	311:315	arg1	technique					327:335	the phase inversion technique	307:335	the phase inversion technique	307:335	We prepared membranes displaying a sub-micron porous structure using the phase inversion technique, clusters of fibers with varying diameter depending on the preparation procedure using electrospinning, and casted films presenting a smooth non porous structure.
32824621	5	57	with	Reaction	896:903	arg1	II					949:950	II	949:950	II	949:950	Reaction of the loaded rhodamine B hydrazide with Cu(II) was confirmed by absorption and emission spectroscopies and by confocal fluorescence imaging, through detection of the product rhodamine B.
32824621	5	57	with	Reaction	896:903	arg1	Cu					946:947	Cu	946:947	Cu(II)	946:951	Reaction of the loaded rhodamine B hydrazide with Cu(II) was confirmed by absorption and emission spectroscopies and by confocal fluorescence imaging, through detection of the product rhodamine B.
32824621	0	58	theme	Acetate	10:16	arg1	Fabrics					18:24	Cellulose Acetate Fabrics	0:24	Cellulose Acetate Fabrics	0:24	Cellulose Acetate Fabrics Loaded with Rhodamine B Hydrazide for Optical Detection of Cu(II).
34186124	0	0	theme	starch	75:80	arg1	mixture					59:65	the extruded mixture	46:65	the extruded mixture of corn starch, resveratrol, and α-amylase	46:108	Microparticle prepared by chitosan coating on the extruded mixture of corn starch, resveratrol, and α-amylase controlled the resveratrol release.
34186124	6	1	theme	resveratrol	907:917	arg1	mixture					883:889	the extruded mixture	870:889	the extruded mixture of corn starch, resveratrol, and α-amylase	870:932	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	7	2	theme	radical	1084:1090	arg1	scavenging					1092:1101	free radical scavenging	1079:1101	the free radical scavenging activity of ABTS+	1075:1119	Chitosan coating slightly improved the free radical scavenging activity of ABTS+.
34186124	6	3	theme	extruded	874:881	arg1	mixture					883:889	the extruded mixture	870:889	the extruded mixture of corn starch, resveratrol, and α-amylase	870:932	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	4	4	theme	chitosan	712:719	arg1	functions					699:707	the functions	695:707	the functions of chitosan	695:719	Considering the bioactive functions of chitosan, microcapsules also obtained the functions of chitosan by chitosan coating.
34186124	6	5	theme	days	978:981	arg1	chasing					983:989	six days chasing	974:989	six days chasing	974:989	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	2	6	theme	hydration	471:479	arg1	disadvantages					412:424	the disadvantages	408:424	the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch	408:498	In the preparation process, the low-temperature extrusion and α-amylase were employed to overcome the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch.
34186124	7	7	theme	scavenging	1092:1101	arg1	activity					1103:1110	the free radical scavenging activity	1075:1110	the free radical scavenging activity of ABTS+	1075:1119	Chitosan coating slightly improved the free radical scavenging activity of ABTS+.
34186124	6	8	theme	chitosan	836:843	arg1	solution					845:852	chitosan solution	836:852	chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase	836:932	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	6	8	theme	chitosan	836:843	arg1	%					856:856	2%	855:856	2%	855:856	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	8	9	theme	composition	1266:1276	arg1	variation					1209:1217	the variation	1205:1217	the variation of morphology, crystal structure, and chemical composition	1205:1276	The particle size variation, SEM, XRD, and FT-IR were also employed to investigate the variation of morphology, crystal structure, and chemical composition.
34186124	1	10	theme	extruded	249:256	arg1	mixture					258:264	the extruded mixture	245:264	the extruded mixture of corn starch, resveratrol, and α-amylase	245:307	Microcapsule was developed by chitosan coating on the microparticle which was prepared by smashing the extruded mixture of corn starch, resveratrol, and α-amylase.
34186124	0	11	theme	resveratrol	83:93	arg1	mixture					59:65	the extruded mixture	46:65	the extruded mixture of corn starch, resveratrol, and α-amylase	46:108	Microparticle prepared by chitosan coating on the extruded mixture of corn starch, resveratrol, and α-amylase controlled the resveratrol release.
34186124	6	12	theme	starch	899:904	arg1	mixture					883:889	the extruded mixture	870:889	the extruded mixture of corn starch, resveratrol, and α-amylase	870:932	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	5	13	theme	chitosan	746:753	arg1	addition					777:784	The chitosan coating and α-amylase addition	742:784	The chitosan coating and α-amylase addition	742:784	The chitosan coating and α-amylase addition improved the release ratio of resveratrol.
34186124	6	14	theme	corn	894:897	arg1	starch					899:904	corn starch	894:904	corn starch	894:904	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	7	15	theme	free	1079:1082	arg1	scavenging					1092:1101	free radical scavenging	1079:1101	the free radical scavenging activity of ABTS+	1075:1119	Chitosan coating slightly improved the free radical scavenging activity of ABTS+.
34186124	7	16	theme	ABTS+	1115:1119	arg1	activity					1103:1110	the free radical scavenging activity	1075:1110	the free radical scavenging activity of ABTS+	1075:1119	Chitosan coating slightly improved the free radical scavenging activity of ABTS+.
34186124	8	17	theme	structure	1242:1250	arg1	variation					1209:1217	the variation	1205:1217	the variation of morphology, crystal structure, and chemical composition	1205:1276	The particle size variation, SEM, XRD, and FT-IR were also employed to investigate the variation of morphology, crystal structure, and chemical composition.
34186124	5	18	theme	coating	755:761	arg1	addition					777:784	The chitosan coating and α-amylase addition	742:784	The chitosan coating and α-amylase addition	742:784	The chitosan coating and α-amylase addition improved the release ratio of resveratrol.
34186124	8	19	theme	crystal	1234:1240	arg1	structure					1242:1250	crystal structure	1234:1250	crystal structure	1234:1250	The particle size variation, SEM, XRD, and FT-IR were also employed to investigate the variation of morphology, crystal structure, and chemical composition.
34186124	6	20	theme	48 h	1026:1029	arg1	chasing					1031:1037	48 h chasing	1026:1037	48 h chasing	1026:1037	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	5	21	theme	resveratrol	816:826	arg1	ratio					807:811	the release ratio	795:811	the release ratio of resveratrol	795:826	The chitosan coating and α-amylase addition improved the release ratio of resveratrol.
34186124	5	22	theme	release	799:805	arg1	ratio					807:811	the release ratio	795:811	the release ratio of resveratrol	795:826	The chitosan coating and α-amylase addition improved the release ratio of resveratrol.
34186124	6	23	theme	α-amylase	924:932	arg1	mixture					883:889	the extruded mixture	870:889	the extruded mixture of corn starch, resveratrol, and α-amylase	870:932	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	0	24	theme	corn	70:73	arg1	starch					75:80	corn starch	70:80	corn starch	70:80	Microparticle prepared by chitosan coating on the extruded mixture of corn starch, resveratrol, and α-amylase controlled the resveratrol release.
34186124	7	25	theme	Chitosan	1040:1047	arg1	coating					1049:1055	Chitosan coating	1040:1055	Chitosan coating	1040:1055	Chitosan coating slightly improved the free radical scavenging activity of ABTS+.
34186124	5	26	theme	α-amylase	767:775	arg1	addition					777:784	The chitosan coating and α-amylase addition	742:784	The chitosan coating and α-amylase addition	742:784	The chitosan coating and α-amylase addition improved the release ratio of resveratrol.
34186124	3	27	theme	microcapsules	567:579	arg1	stability					554:562	the stability	550:562	the stability of microcapsules	550:579	Chitosan-coating retarded starch aging, improved the stability of microcapsules, delayed the release of resveratrol.
34186124	1	28	theme	chitosan	176:183	arg1	coating					185:191	chitosan coating	176:191	chitosan coating on the microparticle which was prepared by smashing the extruded mixture of corn starch, resveratrol, and α-amylase	176:307	Microcapsule was developed by chitosan coating on the microparticle which was prepared by smashing the extruded mixture of corn starch, resveratrol, and α-amylase.
34186124	2	29	theme	gelatinization	433:446	arg1	disadvantages					412:424	the disadvantages	408:424	the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch	408:498	In the preparation process, the low-temperature extrusion and α-amylase were employed to overcome the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch.
34186124	1	30	theme	corn	269:272	arg1	starch					274:279	corn starch	269:279	corn starch	269:279	Microcapsule was developed by chitosan coating on the microparticle which was prepared by smashing the extruded mixture of corn starch, resveratrol, and α-amylase.
34186124	6	31	dep	CESRA	829:833	arg1	solution					845:852	chitosan solution	836:852	chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase	836:932	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	6	31	dep	CESRA	829:833	arg1	%					856:856	2%	855:856	2%	855:856	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	2	32	theme	low	429:431	arg1	gelatinization					433:446	low gelatinization	429:446	low gelatinization	429:446	In the preparation process, the low-temperature extrusion and α-amylase were employed to overcome the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch.
34186124	1	33	theme	starch	274:279	arg1	mixture					258:264	the extruded mixture	245:264	the extruded mixture of corn starch, resveratrol, and α-amylase	245:307	Microcapsule was developed by chitosan coating on the microparticle which was prepared by smashing the extruded mixture of corn starch, resveratrol, and α-amylase.
34186124	3	34	dep	retarded	518:525	arg1	improved					541:548	improved	541:548	improved the stability of microcapsules	541:579	Chitosan-coating retarded starch aging, improved the stability of microcapsules, delayed the release of resveratrol.
34186124	3	34	dep	retarded	518:525	arg1	delayed					582:588	delayed	582:588	delayed the release of resveratrol	582:615	Chitosan-coating retarded starch aging, improved the stability of microcapsules, delayed the release of resveratrol.
34186124	0	35	theme	α-amylase	100:108	arg1	mixture					59:65	the extruded mixture	46:65	the extruded mixture of corn starch, resveratrol, and α-amylase	46:108	Microparticle prepared by chitosan coating on the extruded mixture of corn starch, resveratrol, and α-amylase controlled the resveratrol release.
34186124	4	36	theme	bioactive	634:642	arg1	functions					644:652	the bioactive functions	630:652	the bioactive functions of chitosan	630:664	Considering the bioactive functions of chitosan, microcapsules also obtained the functions of chitosan by chitosan coating.
34186124	2	37	theme	poor	466:469	arg1	hydration					471:479	poor hydration	466:479	poor hydration	466:479	In the preparation process, the low-temperature extrusion and α-amylase were employed to overcome the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch.
34186124	1	38	theme	resveratrol	282:292	arg1	mixture					258:264	the extruded mixture	245:264	the extruded mixture of corn starch, resveratrol, and α-amylase	245:307	Microcapsule was developed by chitosan coating on the microparticle which was prepared by smashing the extruded mixture of corn starch, resveratrol, and α-amylase.
34186124	0	39	theme	resveratrol	125:135	arg1	release					137:143	the resveratrol release	121:143	the resveratrol release	121:143	Microparticle prepared by chitosan coating on the extruded mixture of corn starch, resveratrol, and α-amylase controlled the resveratrol release.
34186124	8	40	theme	morphology	1222:1231	arg1	variation					1209:1217	the variation	1205:1217	the variation of morphology, crystal structure, and chemical composition	1205:1276	The particle size variation, SEM, XRD, and FT-IR were also employed to investigate the variation of morphology, crystal structure, and chemical composition.
34186124	4	41	theme	chitosan	657:664	arg1	functions					644:652	the bioactive functions	630:652	the bioactive functions of chitosan	630:664	Considering the bioactive functions of chitosan, microcapsules also obtained the functions of chitosan by chitosan coating.
34186124	8	42	theme	size	1135:1138	arg1	variation					1140:1148	The particle size variation	1122:1148	The particle size variation	1122:1148	The particle size variation, SEM, XRD, and FT-IR were also employed to investigate the variation of morphology, crystal structure, and chemical composition.
34186124	0	43	theme	extruded	50:57	arg1	mixture					59:65	the extruded mixture	46:65	the extruded mixture of corn starch, resveratrol, and α-amylase	46:108	Microparticle prepared by chitosan coating on the extruded mixture of corn starch, resveratrol, and α-amylase controlled the resveratrol release.
34186124	8	44	theme	particle	1126:1133	arg1	variation					1140:1148	The particle size variation	1122:1148	The particle size variation	1122:1148	The particle size variation, SEM, XRD, and FT-IR were also employed to investigate the variation of morphology, crystal structure, and chemical composition.
34186124	4	45	theme	chitosan	724:731	arg1	coating					733:739	chitosan coating	724:739	chitosan coating	724:739	Considering the bioactive functions of chitosan, microcapsules also obtained the functions of chitosan by chitosan coating.
34186124	2	46	theme	dissolution	449:459	arg1	disadvantages					412:424	the disadvantages	408:424	the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch	408:498	In the preparation process, the low-temperature extrusion and α-amylase were employed to overcome the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch.
34186124	1	47	theme	α-amylase	299:307	arg1	mixture					258:264	the extruded mixture	245:264	the extruded mixture of corn starch, resveratrol, and α-amylase	245:307	Microcapsule was developed by chitosan coating on the microparticle which was prepared by smashing the extruded mixture of corn starch, resveratrol, and α-amylase.
34186124	6	48	dep	%	948:948	arg1	resveratrol					950:960	resveratrol	950:960	86.8% resveratrol at 25 °C in six days chasing	944:989	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	6	48	dep	%	948:948	arg1	resveratrol					1002:1012	resveratrol	1002:1012	resveratrol	1002:1012	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	6	49	from	25 °C	965:969	arg1	%					948:948	86.8%	944:948	86.8% resveratrol at 25 °C in six days chasing	944:989	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	6	49	from	25 °C	965:969	arg1	%					1000:1000	85.3%	996:1000	85.3%	996:1000	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	6	49	from	25 °C	965:969	arg1	chasing					983:989	six days chasing	974:989	six days chasing	974:989	CESRA (chitosan solution (2%) coating on the extruded mixture of corn starch, resveratrol, and α-amylase) released 86.8% resveratrol at 25 °C in six days chasing, and 85.3% resveratrol at 37 °C in 48 h chasing.
34186124	2	50	theme	preparation	317:327	arg1	process					329:335	the preparation process	313:335	the preparation process	313:335	In the preparation process, the low-temperature extrusion and α-amylase were employed to overcome the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch.
34186124	3	51	theme	starch	527:532	arg1	aging					534:538	starch aging	527:538	starch aging	527:538	Chitosan-coating retarded starch aging, improved the stability of microcapsules, delayed the release of resveratrol.
34186124	2	52	theme	starch	493:498	arg1	gelatinization					433:446	low gelatinization	429:446	low gelatinization	429:446	In the preparation process, the low-temperature extrusion and α-amylase were employed to overcome the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch.
34186124	2	52	theme	starch	493:498	arg1	hydration					471:479	poor hydration	466:479	poor hydration	466:479	In the preparation process, the low-temperature extrusion and α-amylase were employed to overcome the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch.
34186124	2	52	theme	starch	493:498	arg1	dissolution					449:459	dissolution	449:459	dissolution	449:459	In the preparation process, the low-temperature extrusion and α-amylase were employed to overcome the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch.
34186124	3	53	theme	resveratrol	605:615	arg1	release					594:600	the release	590:600	the release of resveratrol	590:615	Chitosan-coating retarded starch aging, improved the stability of microcapsules, delayed the release of resveratrol.
34186124	1	54	from	coating	185:191	arg1	microparticle					200:212	the microparticle	196:212	the microparticle which was prepared by smashing the extruded mixture of corn starch, resveratrol, and α-amylase	196:307	Microcapsule was developed by chitosan coating on the microparticle which was prepared by smashing the extruded mixture of corn starch, resveratrol, and α-amylase.
34186124	8	55	theme	chemical	1257:1264	arg1	composition					1266:1276	chemical composition	1257:1276	chemical composition	1257:1276	The particle size variation, SEM, XRD, and FT-IR were also employed to investigate the variation of morphology, crystal structure, and chemical composition.
34186124	2	56	theme	extruded	484:491	arg1	starch					493:498	extruded starch	484:498	extruded starch	484:498	In the preparation process, the low-temperature extrusion and α-amylase were employed to overcome the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch.
34186124	2	57	theme	low-temperature	342:356	arg1	extrusion					358:366	the low-temperature extrusion	338:366	the low-temperature extrusion	338:366	In the preparation process, the low-temperature extrusion and α-amylase were employed to overcome the disadvantages of low gelatinization, dissolution, and poor hydration of extruded starch.
32784024	7	0	theme	antioxidant	1144:1154	arg1	activity					1156:1163	CU antioxidant activity	1141:1163	CU antioxidant activity during storage	1141:1178	The EC coated NPs showed the excessive protection for CU antioxidant activity during storage.
32784024	6	1	theme	NPs	937:939	arg1	stability					924:932	the stability	920:932	the stability	920:932	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	1	2	theme	cellulose	184:192	arg1	ZN-EC					195:199	curcumin (CU) loaded zein-ethyl cellulose (ZN-EC)	152:200	curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water	152:236	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water was prepared using two step antisolvent co-precipitation method.
32784024	1	3	theme	step	261:264	arg1	method					295:300	two step antisolvent co-precipitation method	257:300	two step antisolvent co-precipitation method	257:300	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water was prepared using two step antisolvent co-precipitation method.
32784024	2	4	theme	concentration	387:399	arg1	ratio					401:405	a concentration ratio	385:405	a concentration ratio of 1: 3.5 w/v	385:419	The EC coated NPs were prepared by adding EC in ethyl acetate to the ZN-CU NPs at a concentration ratio of 1: 3.5 w/v.
32784024	2	5	from	EC	345:346	arg1	acetate					357:363	ethyl acetate	351:363	ethyl acetate	351:363	The EC coated NPs were prepared by adding EC in ethyl acetate to the ZN-CU NPs at a concentration ratio of 1: 3.5 w/v.
32784024	3	6	theme	storage	503:509	arg1	time					511:514	storage time	503:514	storage time	503:514	The prepared colloidal suspension of ZN-EC showed high physical stability during storage time.
32784024	1	7	theme	antisolvent	266:276	arg1	method					295:300	two step antisolvent co-precipitation method	257:300	two step antisolvent co-precipitation method	257:300	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water was prepared using two step antisolvent co-precipitation method.
32784024	2	8	theme	coated	310:315	arg1	NPs					317:319	The EC coated NPs	303:319	The EC coated NPs	303:319	The EC coated NPs were prepared by adding EC in ethyl acetate to the ZN-CU NPs at a concentration ratio of 1: 3.5 w/v.
32784024	1	9	theme	co-precipitation	278:293	arg1	method					295:300	two step antisolvent co-precipitation method	257:300	two step antisolvent co-precipitation method	257:300	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water was prepared using two step antisolvent co-precipitation method.
32784024	7	10	theme	CU	1141:1142	arg1	activity					1156:1163	CU antioxidant activity	1141:1163	CU antioxidant activity during storage	1141:1178	The EC coated NPs showed the excessive protection for CU antioxidant activity during storage.
32784024	2	11	theme	EC	307:308	arg1	NPs					317:319	The EC coated NPs	303:319	The EC coated NPs	303:319	The EC coated NPs were prepared by adding EC in ethyl acetate to the ZN-CU NPs at a concentration ratio of 1: 3.5 w/v.
32784024	4	12	theme	ZN-CU-EC	579:586	arg1	suspensions					598:608	ZN-CU-EC colloidal suspensions	579:608	ZN-CU-EC colloidal suspensions	579:608	The particle diameters and zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions were 140 ± 12 nm, 38 ± 2 mV and 179 ± 12 nm, 12 ± 2 mV, respectively.
32784024	7	13	theme	excessive	1116:1124	arg1	protection					1126:1135	the excessive protection	1112:1135	the excessive protection for CU antioxidant activity during storage	1112:1178	The EC coated NPs showed the excessive protection for CU antioxidant activity during storage.
32784024	1	14	theme	curcumin	152:159	arg1	ZN-EC					195:199	curcumin (CU) loaded zein-ethyl cellulose (ZN-EC)	152:200	curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water	152:236	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water was prepared using two step antisolvent co-precipitation method.
32784024	5	15	theme	particles	824:832	arg1	appearance					810:819	the sticky appearance	799:819	the sticky appearance of particles	799:832	Based on Scanning electron microscopy (SEM) images, participation of EC on the surface of ZN-CU particles could reduce the sticky appearance of particles.
32784024	3	16	theme	ZN-EC	459:463	arg1	suspension					445:454	The prepared colloidal suspension	422:454	The prepared colloidal suspension of ZN-EC	422:463	The prepared colloidal suspension of ZN-EC showed high physical stability during storage time.
32784024	8	17	theme	prepared	1200:1207	arg1	NPs					1209:1211	the prepared NPs	1196:1211	the prepared NPs	1196:1211	In conclusion, the prepared NPs, with high physical stability, have good potential for encapsulation and delivery of CU to colon region.
32784024	1	18	theme	ZN-EC	195:199	arg1	nano-dispersion					133:147	The stable colloidal nano-dispersion	112:147	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water	112:236	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water was prepared using two step antisolvent co-precipitation method.
32784024	8	19	theme	high	1219:1222	arg1	stability					1233:1241	high physical stability	1219:1241	high physical stability	1219:1241	In conclusion, the prepared NPs, with high physical stability, have good potential for encapsulation and delivery of CU to colon region.
32784024	3	20	theme	physical	477:484	arg1	stability					486:494	high physical stability	472:494	high physical stability	472:494	The prepared colloidal suspension of ZN-EC showed high physical stability during storage time.
32784024	3	21	theme	prepared	426:433	arg1	suspension					445:454	The prepared colloidal suspension	422:454	The prepared colloidal suspension of ZN-EC	422:463	The prepared colloidal suspension of ZN-EC showed high physical stability during storage time.
32784024	6	22	theme	pH	949:950	arg1	changes					952:958	pH changes	949:958	pH changes	949:958	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	1	23	theme	stable	116:121	arg1	nano-dispersion					133:147	The stable colloidal nano-dispersion	112:147	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water	112:236	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water was prepared using two step antisolvent co-precipitation method.
32784024	8	24	with	NPs	1209:1211	arg1	stability					1233:1241	high physical stability	1219:1241	high physical stability	1219:1241	In conclusion, the prepared NPs, with high physical stability, have good potential for encapsulation and delivery of CU to colon region.
32784024	6	25	from	efficiency	849:858	arg1	NPs					869:871	NPs	869:871	NPs	869:871	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	4	26	theme	potential	549:557	arg1	values					559:564	zeta potential values	544:564	zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions	544:608	The particle diameters and zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions were 140 ± 12 nm, 38 ± 2 mV and 179 ± 12 nm, 12 ± 2 mV, respectively.
32784024	1	27	theme	colloidal	123:131	arg1	nano-dispersion					133:147	The stable colloidal nano-dispersion	112:147	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water	112:236	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water was prepared using two step antisolvent co-precipitation method.
32784024	6	28	theme	pH	1016:1017	arg1	values					1019:1024	different pH values	1006:1024	different pH values (3-8)	1006:1030	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	6	28	theme	pH	1016:1017	arg1	3-8					1027:1029	3-8	1027:1029	3-8	1027:1029	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	0	29	theme	cellulose	35:43	arg1	nanoparticles					55:67	curcumin-zein-ethyl cellulose composite nanoparticles	15:67	curcumin-zein-ethyl cellulose composite nanoparticles	15:67	Fabrication of curcumin-zein-ethyl cellulose composite nanoparticles using antisolvent co-precipitation method.
32784024	4	30	theme	zeta	544:547	arg1	values					559:564	zeta potential values	544:564	zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions	544:608	The particle diameters and zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions were 140 ± 12 nm, 38 ± 2 mV and 179 ± 12 nm, 12 ± 2 mV, respectively.
32784024	5	31	theme	microscopy	707:716	arg1	images					724:729	Scanning electron microscopy (SEM) images	689:729	Scanning electron microscopy (SEM) images	689:729	Based on Scanning electron microscopy (SEM) images, participation of EC on the surface of ZN-CU particles could reduce the sticky appearance of particles.
32784024	5	32	theme	particles	776:784	arg1	surface					759:765	the surface	755:765	the surface of ZN-CU particles	755:784	Based on Scanning electron microscopy (SEM) images, participation of EC on the surface of ZN-CU particles could reduce the sticky appearance of particles.
32784024	6	33	from	values	1019:1024	arg1	NPs					999:1001	NPs	999:1001	NPs at different pH values (3-8)	999:1030	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	1	34	theme	hydrophobic	211:221	arg1	agent					223:227	three hydrophobic agent	205:227	three hydrophobic agent in water	205:236	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water was prepared using two step antisolvent co-precipitation method.
32784024	0	35	theme	curcumin-zein-ethyl	15:33	arg1	nanoparticles					55:67	curcumin-zein-ethyl cellulose composite nanoparticles	15:67	curcumin-zein-ethyl cellulose composite nanoparticles	15:67	Fabrication of curcumin-zein-ethyl cellulose composite nanoparticles using antisolvent co-precipitation method.
32784024	6	36	theme	Encapsulation	835:847	arg1	efficiency					849:858	Encapsulation efficiency	835:858	Encapsulation efficiency of CU in NPs	835:871	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	5	37	from	participation	732:744	arg1	surface					759:765	the surface	755:765	the surface of ZN-CU particles	755:784	Based on Scanning electron microscopy (SEM) images, participation of EC on the surface of ZN-CU particles could reduce the sticky appearance of particles.
32784024	6	38	theme	NPs	1082:1084	arg1	comparison					1062:1071	comparison	1062:1071	comparison of ZN-CU NPs	1062:1084	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	7	39	theme	EC	1091:1092	arg1	NPs					1101:1103	The EC coated NPs	1087:1103	The EC coated NPs	1087:1103	The EC coated NPs showed the excessive protection for CU antioxidant activity during storage.
32784024	2	40	theme	ZN-CU	372:376	arg1	NPs					378:380	the ZN-CU NPs	368:380	the ZN-CU NPs at a concentration ratio of 1: 3.5 w/v	368:419	The EC coated NPs were prepared by adding EC in ethyl acetate to the ZN-CU NPs at a concentration ratio of 1: 3.5 w/v.
32784024	0	41	theme	nanoparticles	55:67	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of curcumin-zein-ethyl cellulose composite nanoparticles using antisolvent co-precipitation method.	0:110	Fabrication of curcumin-zein-ethyl cellulose composite nanoparticles using antisolvent co-precipitation method.
32784024	8	42	theme	good	1249:1252	arg1	potential					1254:1262	good potential	1249:1262	good potential for encapsulation and delivery of CU to colon region	1249:1315	In conclusion, the prepared NPs, with high physical stability, have good potential for encapsulation and delivery of CU to colon region.
32784024	6	43	theme	CU	863:864	arg1	efficiency					849:858	Encapsulation efficiency	835:858	Encapsulation efficiency of CU in NPs	835:871	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	3	44	theme	colloidal	435:443	arg1	suspension					445:454	The prepared colloidal suspension	422:454	The prepared colloidal suspension of ZN-EC	422:463	The prepared colloidal suspension of ZN-EC showed high physical stability during storage time.
32784024	0	45	theme	composite	45:53	arg1	nanoparticles					55:67	curcumin-zein-ethyl cellulose composite nanoparticles	15:67	curcumin-zein-ethyl cellulose composite nanoparticles	15:67	Fabrication of curcumin-zein-ethyl cellulose composite nanoparticles using antisolvent co-precipitation method.
32784024	4	46	theme	particle	521:528	arg1	diameters					530:538	The particle diameters	517:538	The particle diameters	517:538	The particle diameters and zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions were 140 ± 12 nm, 38 ± 2 mV and 179 ± 12 nm, 12 ± 2 mV, respectively.
32784024	4	46	theme	particle	521:528	arg1	140 ± 12 nm					615:625	140 ± 12 nm	615:625	140 ± 12 nm	615:625	The particle diameters and zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions were 140 ± 12 nm, 38 ± 2 mV and 179 ± 12 nm, 12 ± 2 mV, respectively.
32784024	4	47	theme	ZN-CU	569:573	arg1	diameters					530:538	The particle diameters	517:538	The particle diameters	517:538	The particle diameters and zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions were 140 ± 12 nm, 38 ± 2 mV and 179 ± 12 nm, 12 ± 2 mV, respectively.
32784024	4	47	theme	ZN-CU	569:573	arg1	140 ± 12 nm					615:625	140 ± 12 nm	615:625	140 ± 12 nm	615:625	The particle diameters and zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions were 140 ± 12 nm, 38 ± 2 mV and 179 ± 12 nm, 12 ± 2 mV, respectively.
32784024	4	47	theme	ZN-CU	569:573	arg1	values					559:564	zeta potential values	544:564	zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions	544:608	The particle diameters and zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions were 140 ± 12 nm, 38 ± 2 mV and 179 ± 12 nm, 12 ± 2 mV, respectively.
32784024	5	48	theme	sticky	803:808	arg1	appearance					810:819	the sticky appearance	799:819	the sticky appearance of particles	799:832	Based on Scanning electron microscopy (SEM) images, participation of EC on the surface of ZN-CU particles could reduce the sticky appearance of particles.
32784024	8	49	theme	physical	1224:1231	arg1	stability					1233:1241	high physical stability	1219:1241	high physical stability	1219:1241	In conclusion, the prepared NPs, with high physical stability, have good potential for encapsulation and delivery of CU to colon region.
32784024	0	50	theme	antisolvent	75:85	arg1	method					104:109	antisolvent co-precipitation method	75:109	antisolvent co-precipitation method	75:109	Fabrication of curcumin-zein-ethyl cellulose composite nanoparticles using antisolvent co-precipitation method.
32784024	8	51	theme	CU	1298:1299	arg1	delivery					1286:1293	delivery	1286:1293	delivery of CU to colon region	1286:1315	In conclusion, the prepared NPs, with high physical stability, have good potential for encapsulation and delivery of CU to colon region.
32784024	8	51	theme	CU	1298:1299	arg1	encapsulation					1268:1280	encapsulation	1268:1280	encapsulation	1268:1280	In conclusion, the prepared NPs, with high physical stability, have good potential for encapsulation and delivery of CU to colon region.
32784024	2	52	theme	ethyl	351:355	arg1	acetate					357:363	ethyl acetate	351:363	ethyl acetate	351:363	The EC coated NPs were prepared by adding EC in ethyl acetate to the ZN-CU NPs at a concentration ratio of 1: 3.5 w/v.
32784024	8	53	contain	have	1244:1247	arg2	potential					1254:1262	good potential	1249:1262	good potential for encapsulation and delivery of CU to colon region	1249:1315	In conclusion, the prepared NPs, with high physical stability, have good potential for encapsulation and delivery of CU to colon region.
32784024	8	53	contain	have	1244:1247	arg1	NPs					1209:1211	the prepared NPs	1196:1211	the prepared NPs	1196:1211	In conclusion, the prepared NPs, with high physical stability, have good potential for encapsulation and delivery of CU to colon region.
32784024	4	54	theme	colloidal	588:596	arg1	suspensions					598:608	ZN-CU-EC colloidal suspensions	579:608	ZN-CU-EC colloidal suspensions	579:608	The particle diameters and zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions were 140 ± 12 nm, 38 ± 2 mV and 179 ± 12 nm, 12 ± 2 mV, respectively.
32784024	7	55	theme	coated	1094:1099	arg1	NPs					1101:1103	The EC coated NPs	1087:1103	The EC coated NPs	1087:1103	The EC coated NPs showed the excessive protection for CU antioxidant activity during storage.
32784024	5	56	theme	Scanning	689:696	arg1	SEM					719:721	SEM	719:721	SEM	719:721	Based on Scanning electron microscopy (SEM) images, participation of EC on the surface of ZN-CU particles could reduce the sticky appearance of particles.
32784024	5	56	theme	Scanning	689:696	arg1	microscopy					707:716	Scanning electron microscopy	689:716	Scanning electron microscopy (SEM) images	689:729	Based on Scanning electron microscopy (SEM) images, participation of EC on the surface of ZN-CU particles could reduce the sticky appearance of particles.
32784024	5	57	theme	ZN-CU	770:774	arg1	particles					776:784	ZN-CU particles	770:784	ZN-CU particles	770:784	Based on Scanning electron microscopy (SEM) images, participation of EC on the surface of ZN-CU particles could reduce the sticky appearance of particles.
32784024	1	58	from	agent	223:227	arg1	water					232:236	water	232:236	water	232:236	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water was prepared using two step antisolvent co-precipitation method.
32784024	1	59	theme	CU	162:163	arg1	ZN-EC					195:199	curcumin (CU) loaded zein-ethyl cellulose (ZN-EC)	152:200	curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water	152:236	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water was prepared using two step antisolvent co-precipitation method.
32784024	8	60	theme	colon	1304:1308	arg1	region					1310:1315	colon region	1304:1315	colon region	1304:1315	In conclusion, the prepared NPs, with high physical stability, have good potential for encapsulation and delivery of CU to colon region.
32784024	6	61	theme	CU	991:992	arg1	rate					983:986	and release rate	971:986	rate	983:986	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	5	62	theme	electron	698:705	arg1	SEM					719:721	SEM	719:721	SEM	719:721	Based on Scanning electron microscopy (SEM) images, participation of EC on the surface of ZN-CU particles could reduce the sticky appearance of particles.
32784024	5	62	theme	electron	698:705	arg1	microscopy					707:716	Scanning electron microscopy	689:716	Scanning electron microscopy (SEM) images	689:729	Based on Scanning electron microscopy (SEM) images, participation of EC on the surface of ZN-CU particles could reduce the sticky appearance of particles.
32784024	6	63	theme	different	1006:1014	arg1	values					1019:1024	different pH values	1006:1024	different pH values (3-8)	1006:1030	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	6	63	theme	different	1006:1014	arg1	3-8					1027:1029	3-8	1027:1029	3-8	1027:1029	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	3	64	theme	high	472:475	arg1	stability					486:494	high physical stability	472:494	high physical stability	472:494	The prepared colloidal suspension of ZN-EC showed high physical stability during storage time.
32784024	6	65	theme	ZN-CU	1076:1080	arg1	NPs					1082:1084	ZN-CU NPs	1076:1084	ZN-CU NPs	1076:1084	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	4	66	theme	suspensions	598:608	arg1	diameters					530:538	The particle diameters	517:538	The particle diameters	517:538	The particle diameters and zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions were 140 ± 12 nm, 38 ± 2 mV and 179 ± 12 nm, 12 ± 2 mV, respectively.
32784024	4	66	theme	suspensions	598:608	arg1	140 ± 12 nm					615:625	140 ± 12 nm	615:625	140 ± 12 nm	615:625	The particle diameters and zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions were 140 ± 12 nm, 38 ± 2 mV and 179 ± 12 nm, 12 ± 2 mV, respectively.
32784024	4	66	theme	suspensions	598:608	arg1	values					559:564	zeta potential values	544:564	zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions	544:608	The particle diameters and zeta potential values of ZN-CU and ZN-CU-EC colloidal suspensions were 140 ± 12 nm, 38 ± 2 mV and 179 ± 12 nm, 12 ± 2 mV, respectively.
32784024	5	67	theme	EC	749:750	arg1	participation					732:744	participation	732:744	participation of EC on the surface of ZN-CU particles	732:784	Based on Scanning electron microscopy (SEM) images, participation of EC on the surface of ZN-CU particles could reduce the sticky appearance of particles.
32784024	2	68	from	ratio	401:405	arg1	NPs					378:380	the ZN-CU NPs	368:380	the ZN-CU NPs at a concentration ratio of 1: 3.5 w/v	368:419	The EC coated NPs were prepared by adding EC in ethyl acetate to the ZN-CU NPs at a concentration ratio of 1: 3.5 w/v.
32784024	1	69	theme	loaded	166:171	arg1	cellulose					184:192	loaded zein-ethyl cellulose	166:192	curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water	152:236	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water was prepared using two step antisolvent co-precipitation method.
32784024	0	70	theme	co-precipitation	87:102	arg1	method					104:109	antisolvent co-precipitation method	75:109	antisolvent co-precipitation method	75:109	Fabrication of curcumin-zein-ethyl cellulose composite nanoparticles using antisolvent co-precipitation method.
32784024	6	71	theme	EC	912:913	arg1	precipitation					895:907	precipitation	895:907	precipitation of EC	895:913	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
32784024	2	72	theme	3.5 w/v	413:419	arg1	ratio					401:405	a concentration ratio	385:405	a concentration ratio of 1: 3.5 w/v	385:419	The EC coated NPs were prepared by adding EC in ethyl acetate to the ZN-CU NPs at a concentration ratio of 1: 3.5 w/v.
32784024	1	73	theme	zein-ethyl	173:182	arg1	cellulose					184:192	loaded zein-ethyl cellulose	166:192	curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water	152:236	The stable colloidal nano-dispersion of curcumin (CU) loaded zein-ethyl cellulose (ZN-EC) as three hydrophobic agent in water was prepared using two step antisolvent co-precipitation method.
32784024	6	74	theme	release	975:981	arg1	rate					983:986	and release rate	971:986	rate	983:986	Encapsulation efficiency of CU in NPs did not improve after precipitation of EC, but the stability of NPs against pH changes, increased and release rate of CU from NPs at different pH values (3-8) were significantly reduced in comparison of ZN-CU NPs.
34513064	4	0	theme	3T3-L1	899:904	arg1	fibroblasts					912:922	3T3-L1 mouse fibroblasts	899:922	3T3-L1 mouse fibroblasts	899:922	Cytotoxicity of glycoluril-modified film materials derived from Na-CMC was studied by incubating cell cultures of 3T3-L1 mouse fibroblasts directly with extracts from films under study using a colorimetric test.
34513064	3	1	theme	films	569:573	arg1	parameters					542:551	Physicomechanical parameters	524:551	Physicomechanical parameters of the obtained films	524:573	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	2	2	dep	Materials	269:277	arg1	materials					309:317	The modified film materials	291:317	Materials and Methods The modified film materials	269:317	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	12	3	dep	Conclusion	1818:1827	arg1	promising					1852:1860	promising	1852:1860	promising	1852:1860	Conclusion The obtained films are promising for preventing adhesions as a barrier-type agent.
34513064	12	3	dep	Conclusion	1818:1827	arg1	films					1842:1846	The obtained films	1829:1846	The obtained films	1829:1846	Conclusion The obtained films are promising for preventing adhesions as a barrier-type agent.
34513064	3	4	theme	improved	720:727	arg1	extensometer					735:746	improved video extensometer	720:746	improved video extensometer	720:746	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	3	5	theme	MKC-25	757:762	arg1	Russia					776:781	Russia	776:781	Russia	776:781	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	3	5	theme	MKC-25	757:762	arg1	micrometer					764:773	the MKC-25 micrometer	753:773	the MKC-25 micrometer (Russia)	753:782	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	13	6	theme	Modifying	1912:1920	arg1	Na-CMC					1922:1927	Modifying Na-CMC	1912:1927	Modifying Na-CMC with glycoluril	1912:1943	Modifying Na-CMC with glycoluril made it possible to create films that prevent formation of flat adhesions, have improved physical and mechanical properties and no cytotoxic effect.
34513064	8	7	dep	Results	1363:1369	arg1	found					1378:1382	found	1378:1382	was found that extracts obtained from film materials derived from Na-CMC modified with glycoluril at a concentration of 0.01 and 0.05 wt	1374:1509	Results It was found that extracts obtained from film materials derived from Na-CMC modified with glycoluril at a concentration of 0.01 and 0.05 wt.
34513064	3	8	theme	electromechanical	624:640	arg1	machine					650:656	the Instron 3369 universal electromechanical testing machine	597:656	the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia)	597:782	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	3	8	theme	electromechanical	624:640	arg1	Britain					665:671	Great Britain	659:671	Great Britain	659:671	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	4	9	theme	fibroblasts	912:922	arg1	cultures					887:894	cell cultures	882:894	cell cultures of 3T3-L1 mouse fibroblasts	882:922	Cytotoxicity of glycoluril-modified film materials derived from Na-CMC was studied by incubating cell cultures of 3T3-L1 mouse fibroblasts directly with extracts from films under study using a colorimetric test.
34513064	6	10	theme	adhesions	1242:1250	arg1	presence					1230:1237	The presence	1226:1237	The presence of adhesions	1226:1250	The presence of adhesions was assessed on day 8 after the operation.
34513064	1	11	theme	study	125:129	arg1	aim					114:116	The aim	110:116	The aim of the study	110:129	The aim of the study was to develop composite film materials derived from modified sodium carboxymethyl cellulose and to evaluate their anti-adhesive effects.
34513064	3	12	theme	Great	659:663	arg1	machine					650:656	the Instron 3369 universal electromechanical testing machine	597:656	the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia)	597:782	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	3	12	theme	Great	659:663	arg1	Britain					665:671	Great Britain	659:671	Great Britain	659:671	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	2	13	theme	room	506:509	arg1	temperature					511:521	room temperature	506:521	room temperature	506:521	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	0	14	theme	Glycoluril-Modified	58:76	arg1	Cellulose					99:107	Glycoluril-Modified Sodium Carboxymethyl Cellulose	58:107	Glycoluril-Modified Sodium Carboxymethyl Cellulose	58:107	Anti-Adhesion Effect of Composite Film Materials Based on Glycoluril-Modified Sodium Carboxymethyl Cellulose.
34513064	13	15	theme	improved	2025:2032	arg1	properties					2058:2067	improved physical and mechanical properties	2025:2067	improved physical and mechanical properties	2025:2067	Modifying Na-CMC with glycoluril made it possible to create films that prevent formation of flat adhesions, have improved physical and mechanical properties and no cytotoxic effect.
34513064	1	16	theme	composite	146:154	arg1	materials					161:169	composite film materials	146:169	composite film materials derived from modified sodium carboxymethyl cellulose	146:222	The aim of the study was to develop composite film materials derived from modified sodium carboxymethyl cellulose and to evaluate their anti-adhesive effects.
34513064	11	17	theme	flat	1750:1753	arg1	adhesions					1755:1763	flat adhesions	1750:1763	flat adhesions	1750:1763	When film materials under study were placed in the abdominal cavity between the injured areas, formation of flat adhesions was not observed or observed in one case out of ten.
34513064	0	18	theme	Carboxymethyl	85:97	arg1	Cellulose					99:107	Glycoluril-Modified Sodium Carboxymethyl Cellulose	58:107	Glycoluril-Modified Sodium Carboxymethyl Cellulose	58:107	Anti-Adhesion Effect of Composite Film Materials Based on Glycoluril-Modified Sodium Carboxymethyl Cellulose.
34513064	5	19	theme	deserosed	1145:1153	arg1	surface					1155:1161	the deserosed surface	1141:1161	the deserosed surface of the abdominal wall anatomically opposite the abrasion area	1141:1223	Their anti-adhesion effect was investigated on 40 female Wistar rats by modeling a flat adhesion by inducing abrasion of the cecum and suturing the deserosed surface of the abdominal wall anatomically opposite the abrasion area.
34513064	2	20	from	homogenization	453:466	arg1	drying					491:496	a vacuum drying	482:496	a vacuum drying oven at room temperature	482:521	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	13	21	theme	flat	2004:2007	arg1	adhesions					2009:2017	flat adhesions	2004:2017	flat adhesions	2004:2017	Modifying Na-CMC with glycoluril made it possible to create films that prevent formation of flat adhesions, have improved physical and mechanical properties and no cytotoxic effect.
34513064	2	22	theme	film	304:307	arg1	materials					309:317	The modified film materials	291:317	Materials and Methods The modified film materials	269:317	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	4	23	theme	colorimetric	978:989	arg1	test					991:994	a colorimetric test	976:994	a colorimetric test	976:994	Cytotoxicity of glycoluril-modified film materials derived from Na-CMC was studied by incubating cell cultures of 3T3-L1 mouse fibroblasts directly with extracts from films under study using a colorimetric test.
34513064	2	24	from	drying	472:477	arg1	drying					491:496	a vacuum drying	482:496	a vacuum drying oven at room temperature	482:521	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	5	25	theme	cecum	1122:1126	arg1	abrasion					1106:1113	abrasion	1106:1113	abrasion of the cecum	1106:1126	Their anti-adhesion effect was investigated on 40 female Wistar rats by modeling a flat adhesion by inducing abrasion of the cecum and suturing the deserosed surface of the abdominal wall anatomically opposite the abrasion area.
34513064	5	26	theme	anti-adhesion	1003:1015	arg1	effect					1017:1022	Their anti-adhesion effect	997:1022	Their anti-adhesion effect	997:1022	Their anti-adhesion effect was investigated on 40 female Wistar rats by modeling a flat adhesion by inducing abrasion of the cecum and suturing the deserosed surface of the abdominal wall anatomically opposite the abrasion area.
34513064	0	27	theme	Anti-Adhesion	0:12	arg1	Effect					14:19	Anti-Adhesion Effect	0:19	Anti-Adhesion Effect of Composite Film Materials	0:47	Anti-Adhesion Effect of Composite Film Materials Based on Glycoluril-Modified Sodium Carboxymethyl Cellulose.
34513064	13	28	theme	cytotoxic	2076:2084	arg1	effect					2086:2091	no cytotoxic effect	2073:2091	no cytotoxic effect	2073:2091	Modifying Na-CMC with glycoluril made it possible to create films that prevent formation of flat adhesions, have improved physical and mechanical properties and no cytotoxic effect.
34513064	2	29	theme	subsequent	442:451	arg1	homogenization					453:466	subsequent homogenization	442:466	subsequent homogenization	442:466	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	13	30	with	Na-CMC	1922:1927	arg1	glycoluril					1934:1943	glycoluril	1934:1943	glycoluril	1934:1943	Modifying Na-CMC with glycoluril made it possible to create films that prevent formation of flat adhesions, have improved physical and mechanical properties and no cytotoxic effect.
34513064	9	31	theme	mouse	1561:1565	arg1	fibroblasts					1567:1577	mouse fibroblasts	1561:1577	mouse fibroblasts 3T3-L1	1561:1584	% had no cytotoxic effect on the cell culture of mouse fibroblasts 3T3-L1.
34513064	2	32	theme	vacuum	484:489	arg1	drying					491:496	a vacuum drying	482:496	a vacuum drying oven at room temperature	482:521	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	1	33	attach	derived	171:177	arg2	materials					161:169	composite film materials	146:169	composite film materials derived from modified sodium carboxymethyl cellulose	146:222	The aim of the study was to develop composite film materials derived from modified sodium carboxymethyl cellulose and to evaluate their anti-adhesive effects.
34513064	1	33	attach	derived	171:177	arg1	cellulose					214:222	modified sodium carboxymethyl cellulose	184:222	modified sodium carboxymethyl cellulose	184:222	The aim of the study was to develop composite film materials derived from modified sodium carboxymethyl cellulose and to evaluate their anti-adhesive effects.
34513064	0	34	theme	Film	34:37	arg1	Materials					39:47	Composite Film Materials	24:47	Composite Film Materials	24:47	Anti-Adhesion Effect of Composite Film Materials Based on Glycoluril-Modified Sodium Carboxymethyl Cellulose.
34513064	12	35	theme	obtained	1833:1840	arg1	promising					1852:1860	promising	1852:1860	promising	1852:1860	Conclusion The obtained films are promising for preventing adhesions as a barrier-type agent.
34513064	12	35	theme	obtained	1833:1840	arg1	films					1842:1846	The obtained films	1829:1846	The obtained films	1829:1846	Conclusion The obtained films are promising for preventing adhesions as a barrier-type agent.
34513064	5	36	theme	female	1047:1052	arg1	rats					1061:1064	40 female Wistar rats	1044:1064	40 female Wistar rats	1044:1064	Their anti-adhesion effect was investigated on 40 female Wistar rats by modeling a flat adhesion by inducing abrasion of the cecum and suturing the deserosed surface of the abdominal wall anatomically opposite the abrasion area.
34513064	5	37	theme	abdominal	1170:1178	arg1	wall					1180:1183	the abdominal wall	1166:1183	the abdominal wall anatomically opposite the abrasion area	1166:1223	Their anti-adhesion effect was investigated on 40 female Wistar rats by modeling a flat adhesion by inducing abrasion of the cecum and suturing the deserosed surface of the abdominal wall anatomically opposite the abrasion area.
34513064	7	38	theme	Commercial	1295:1304	arg1	sample					1355:1360	a reference sample	1343:1360	a reference sample	1343:1360	Commercial membrane Seprafilm (USA) was used as a reference sample.
34513064	7	38	theme	Commercial	1295:1304	arg1	USA					1326:1328	USA	1326:1328	USA	1326:1328	Commercial membrane Seprafilm (USA) was used as a reference sample.
34513064	7	38	theme	Commercial	1295:1304	arg1	Seprafilm					1315:1323	Commercial membrane Seprafilm	1295:1323	Commercial membrane Seprafilm (USA)	1295:1329	Commercial membrane Seprafilm (USA) was used as a reference sample.
34513064	13	39	dep	adhesions	2009:2017	arg1	have					2020:2023	have	2020:2023	have improved physical and mechanical properties	2020:2067	Modifying Na-CMC with glycoluril made it possible to create films that prevent formation of flat adhesions, have improved physical and mechanical properties and no cytotoxic effect.
34513064	9	40	theme	3T3-L1	1579:1584	arg1	culture					1550:1556	the cell culture	1541:1556	the cell culture of mouse fibroblasts 3T3-L1	1541:1584	% had no cytotoxic effect on the cell culture of mouse fibroblasts 3T3-L1.
34513064	2	41	theme	carboxymethyl	354:366	arg1	cellulose					368:376	sodium carboxymethyl cellulose	347:376	sodium carboxymethyl cellulose (Na-CMC)	347:385	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	2	41	theme	carboxymethyl	354:366	arg1	Na-CMC					379:384	Na-CMC	379:384	Na-CMC	379:384	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	11	42	theme	abdominal	1693:1701	arg1	cavity					1703:1708	the abdominal cavity	1689:1708	the abdominal cavity between the injured areas	1689:1734	When film materials under study were placed in the abdominal cavity between the injured areas, formation of flat adhesions was not observed or observed in one case out of ten.
34513064	4	43	theme	film	821:824	arg1	materials					826:834	glycoluril-modified film materials	801:834	glycoluril-modified film materials derived from Na-CMC	801:854	Cytotoxicity of glycoluril-modified film materials derived from Na-CMC was studied by incubating cell cultures of 3T3-L1 mouse fibroblasts directly with extracts from films under study using a colorimetric test.
34513064	3	44	theme	Physicomechanical	524:540	arg1	parameters					542:551	Physicomechanical parameters	524:551	Physicomechanical parameters of the obtained films	524:573	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	1	45	theme	anti-adhesive	246:258	arg1	effects					260:266	their anti-adhesive effects	240:266	their anti-adhesive effects	240:266	The aim of the study was to develop composite film materials derived from modified sodium carboxymethyl cellulose and to evaluate their anti-adhesive effects.
34513064	2	46	with	solution	401:408	arg1	homogenization					453:466	subsequent homogenization	442:466	subsequent homogenization	442:466	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	2	46	with	solution	401:408	arg1	drying					472:477	drying	472:477	drying	472:477	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	3	47	theme	video	729:733	arg1	extensometer					735:746	improved video extensometer	720:746	improved video extensometer	720:746	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	4	48	theme	cell	882:885	arg1	cultures					887:894	cell cultures	882:894	cell cultures of 3T3-L1 mouse fibroblasts	882:922	Cytotoxicity of glycoluril-modified film materials derived from Na-CMC was studied by incubating cell cultures of 3T3-L1 mouse fibroblasts directly with extracts from films under study using a colorimetric test.
34513064	3	49	theme	obtained	560:567	arg1	films					569:573	the obtained films	556:573	the obtained films	556:573	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	2	50	theme	modified	295:302	arg1	materials					309:317	The modified film materials	291:317	Materials and Methods The modified film materials	269:317	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	10	51	theme	Flat	1587:1590	arg1	adhesions					1592:1600	Flat adhesions	1587:1600	Flat adhesions	1587:1600	Flat adhesions were not detected when using Seprafilm.
34513064	11	52	theme	film	1647:1650	arg1	materials					1652:1660	film materials	1647:1660	film materials under study	1647:1672	When film materials under study were placed in the abdominal cavity between the injured areas, formation of flat adhesions was not observed or observed in one case out of ten.
34513064	1	53	theme	modified	184:191	arg1	cellulose					214:222	modified sodium carboxymethyl cellulose	184:222	modified sodium carboxymethyl cellulose	184:222	The aim of the study was to develop composite film materials derived from modified sodium carboxymethyl cellulose and to evaluate their anti-adhesive effects.
34513064	1	54	theme	carboxymethyl	200:212	arg1	cellulose					214:222	modified sodium carboxymethyl cellulose	184:222	modified sodium carboxymethyl cellulose	184:222	The aim of the study was to develop composite film materials derived from modified sodium carboxymethyl cellulose and to evaluate their anti-adhesive effects.
34513064	4	55	from	films	952:956	arg1	extracts					938:945	extracts	938:945	extracts from films under study using a colorimetric test	938:994	Cytotoxicity of glycoluril-modified film materials derived from Na-CMC was studied by incubating cell cultures of 3T3-L1 mouse fibroblasts directly with extracts from films under study using a colorimetric test.
34513064	3	56	theme	universal	614:622	arg1	machine					650:656	the Instron 3369 universal electromechanical testing machine	597:656	the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia)	597:782	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	3	56	theme	universal	614:622	arg1	Britain					665:671	Great Britain	659:671	Great Britain	659:671	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	1	57	theme	sodium	193:198	arg1	cellulose					214:222	modified sodium carboxymethyl cellulose	184:222	modified sodium carboxymethyl cellulose	184:222	The aim of the study was to develop composite film materials derived from modified sodium carboxymethyl cellulose and to evaluate their anti-adhesive effects.
34513064	3	58	theme	Instron	601:607	arg1	machine					650:656	the Instron 3369 universal electromechanical testing machine	597:656	the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia)	597:782	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	3	58	theme	Instron	601:607	arg1	Britain					665:671	Great Britain	659:671	Great Britain	659:671	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	4	59	theme	mouse	906:910	arg1	fibroblasts					912:922	3T3-L1 mouse fibroblasts	899:922	3T3-L1 mouse fibroblasts	899:922	Cytotoxicity of glycoluril-modified film materials derived from Na-CMC was studied by incubating cell cultures of 3T3-L1 mouse fibroblasts directly with extracts from films under study using a colorimetric test.
34513064	4	60	attach	derived	836:842	arg2	materials					826:834	glycoluril-modified film materials	801:834	glycoluril-modified film materials derived from Na-CMC	801:854	Cytotoxicity of glycoluril-modified film materials derived from Na-CMC was studied by incubating cell cultures of 3T3-L1 mouse fibroblasts directly with extracts from films under study using a colorimetric test.
34513064	4	60	attach	derived	836:842	arg1	Na-CMC					849:854	Na-CMC	849:854	Na-CMC	849:854	Cytotoxicity of glycoluril-modified film materials derived from Na-CMC was studied by incubating cell cultures of 3T3-L1 mouse fibroblasts directly with extracts from films under study using a colorimetric test.
34513064	0	61	theme	Sodium	78:83	arg1	Cellulose					99:107	Glycoluril-Modified Sodium Carboxymethyl Cellulose	58:107	Glycoluril-Modified Sodium Carboxymethyl Cellulose	58:107	Anti-Adhesion Effect of Composite Film Materials Based on Glycoluril-Modified Sodium Carboxymethyl Cellulose.
34513064	5	62	theme	flat	1080:1083	arg1	adhesion					1085:1092	a flat adhesion	1078:1092	a flat adhesion	1078:1092	Their anti-adhesion effect was investigated on 40 female Wistar rats by modeling a flat adhesion by inducing abrasion of the cecum and suturing the deserosed surface of the abdominal wall anatomically opposite the abrasion area.
34513064	3	63	theme	testing	642:648	arg1	machine					650:656	the Instron 3369 universal electromechanical testing machine	597:656	the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia)	597:782	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	3	63	theme	testing	642:648	arg1	Britain					665:671	Great Britain	659:671	Great Britain	659:671	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	7	64	theme	reference	1345:1353	arg1	sample					1355:1360	a reference sample	1343:1360	a reference sample	1343:1360	Commercial membrane Seprafilm (USA) was used as a reference sample.
34513064	7	64	theme	reference	1345:1353	arg1	Seprafilm					1315:1323	Commercial membrane Seprafilm	1295:1323	Commercial membrane Seprafilm (USA)	1295:1329	Commercial membrane Seprafilm (USA) was used as a reference sample.
34513064	11	65	theme	injured	1722:1728	arg1	areas					1730:1734	the injured areas	1718:1734	the injured areas	1718:1734	When film materials under study were placed in the abdominal cavity between the injured areas, formation of flat adhesions was not observed or observed in one case out of ten.
34513064	13	66	theme	physical	2034:2041	arg1	properties					2058:2067	improved physical and mechanical properties	2025:2067	improved physical and mechanical properties	2025:2067	Modifying Na-CMC with glycoluril made it possible to create films that prevent formation of flat adhesions, have improved physical and mechanical properties and no cytotoxic effect.
34513064	1	67	theme	film	156:159	arg1	materials					161:169	composite film materials	146:169	composite film materials derived from modified sodium carboxymethyl cellulose	146:222	The aim of the study was to develop composite film materials derived from modified sodium carboxymethyl cellulose and to evaluate their anti-adhesive effects.
34513064	8	68	theme	wt	1508:1509	arg1	concentration					1477:1489	a concentration	1475:1489	a concentration of 0.01 and 0.05 wt	1475:1509	Results It was found that extracts obtained from film materials derived from Na-CMC modified with glycoluril at a concentration of 0.01 and 0.05 wt.
34513064	11	69	theme	adhesions	1755:1763	arg1	formation					1737:1745	formation	1737:1745	formation of flat adhesions	1737:1763	When film materials under study were placed in the abdominal cavity between the injured areas, formation of flat adhesions was not observed or observed in one case out of ten.
34513064	13	70	theme	mechanical	2047:2056	arg1	properties					2058:2067	improved physical and mechanical properties	2025:2067	improved physical and mechanical properties	2025:2067	Modifying Na-CMC with glycoluril made it possible to create films that prevent formation of flat adhesions, have improved physical and mechanical properties and no cytotoxic effect.
34513064	12	71	theme	barrier-type	1892:1903	arg1	agent					1905:1909	a barrier-type agent	1890:1909	a barrier-type agent	1890:1909	Conclusion The obtained films are promising for preventing adhesions as a barrier-type agent.
34513064	12	71	theme	barrier-type	1892:1903	arg1	adhesions					1877:1885	adhesions	1877:1885	adhesions	1877:1885	Conclusion The obtained films are promising for preventing adhesions as a barrier-type agent.
34513064	9	72	theme	cytotoxic	1521:1529	arg1	effect					1531:1536	no cytotoxic effect	1518:1536	no cytotoxic effect	1518:1536	% had no cytotoxic effect on the cell culture of mouse fibroblasts 3T3-L1.
34513064	13	73	theme	adhesions	2009:2017	arg1	formation					1991:1999	formation	1991:1999	formation of flat adhesions, have improved physical and mechanical properties	1991:2067	Modifying Na-CMC with glycoluril made it possible to create films that prevent formation of flat adhesions, have improved physical and mechanical properties and no cytotoxic effect.
34513064	13	73	theme	adhesions	2009:2017	arg1	effect					2086:2091	no cytotoxic effect	2073:2091	no cytotoxic effect	2073:2091	Modifying Na-CMC with glycoluril made it possible to create films that prevent formation of flat adhesions, have improved physical and mechanical properties and no cytotoxic effect.
34513064	11	74	dep	ten	1813:1815	arg1	out					1806:1808	out	1806:1808	out	1806:1808	When film materials under study were placed in the abdominal cavity between the injured areas, formation of flat adhesions was not observed or observed in one case out of ten.
34513064	7	75	used	used	1335:1338	arg2	USA					1326:1328	USA	1326:1328	USA	1326:1328	Commercial membrane Seprafilm (USA) was used as a reference sample.
34513064	7	75	used	used	1335:1338	arg2	Seprafilm					1315:1323	Commercial membrane Seprafilm	1295:1323	Commercial membrane Seprafilm (USA)	1295:1329	Commercial membrane Seprafilm (USA) was used as a reference sample.
34513064	7	75	used	used	1335:1338	arg2	sample					1355:1360	a reference sample	1343:1360	a reference sample	1343:1360	Commercial membrane Seprafilm (USA) was used as a reference sample.
34513064	9	76	theme	cell	1545:1548	arg1	culture					1550:1556	the cell culture	1541:1556	the cell culture of mouse fibroblasts 3T3-L1	1541:1584	% had no cytotoxic effect on the cell culture of mouse fibroblasts 3T3-L1.
34513064	5	77	dep	wall	1180:1183	arg1	area					1220:1223	the abrasion area	1207:1223	the abdominal wall anatomically opposite the abrasion area	1166:1223	Their anti-adhesion effect was investigated on 40 female Wistar rats by modeling a flat adhesion by inducing abrasion of the cecum and suturing the deserosed surface of the abdominal wall anatomically opposite the abrasion area.
34513064	3	78	theme	climatic	690:697	arg1	chamber					699:705	a climatic chamber	688:705	a climatic chamber (300-523 K)	688:717	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	3	78	theme	climatic	690:697	arg1	K					716:716	300-523 K	708:716	300-523 K	708:716	Physicomechanical parameters of the obtained films were determined using the Instron 3369 universal electromechanical testing machine (Great Britain) equipped with a climatic chamber (300-523 K), improved video extensometer, and the MKC-25 micrometer (Russia).
34513064	2	79	theme	aqueous	393:399	arg1	solution					401:408	an aqueous solution	390:408	an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature	390:521	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	0	80	theme	Composite	24:32	arg1	Materials					39:47	Composite Film Materials	24:47	Composite Film Materials	24:47	Anti-Adhesion Effect of Composite Film Materials Based on Glycoluril-Modified Sodium Carboxymethyl Cellulose.
34513064	5	81	theme	opposite	1198:1205	arg1	wall					1180:1183	the abdominal wall	1166:1183	the abdominal wall anatomically opposite the abrasion area	1166:1223	Their anti-adhesion effect was investigated on 40 female Wistar rats by modeling a flat adhesion by inducing abrasion of the cecum and suturing the deserosed surface of the abdominal wall anatomically opposite the abrasion area.
34513064	0	82	theme	Materials	39:47	arg1	Effect					14:19	Anti-Adhesion Effect	0:19	Anti-Adhesion Effect of Composite Film Materials	0:47	Anti-Adhesion Effect of Composite Film Materials Based on Glycoluril-Modified Sodium Carboxymethyl Cellulose.
34513064	5	83	theme	abrasion	1211:1218	arg1	area					1220:1223	the abrasion area	1207:1223	the abdominal wall anatomically opposite the abrasion area	1166:1223	Their anti-adhesion effect was investigated on 40 female Wistar rats by modeling a flat adhesion by inducing abrasion of the cecum and suturing the deserosed surface of the abdominal wall anatomically opposite the abrasion area.
34513064	9	84	theme	fibroblasts	1567:1577	arg1	3T3-L1					1579:1584	mouse fibroblasts 3T3-L1	1561:1584	mouse fibroblasts 3T3-L1	1561:1584	% had no cytotoxic effect on the cell culture of mouse fibroblasts 3T3-L1.
34513064	7	85	theme	membrane	1306:1313	arg1	sample					1355:1360	a reference sample	1343:1360	a reference sample	1343:1360	Commercial membrane Seprafilm (USA) was used as a reference sample.
34513064	7	85	theme	membrane	1306:1313	arg1	USA					1326:1328	USA	1326:1328	USA	1326:1328	Commercial membrane Seprafilm (USA) was used as a reference sample.
34513064	7	85	theme	membrane	1306:1313	arg1	Seprafilm					1315:1323	Commercial membrane Seprafilm	1295:1323	Commercial membrane Seprafilm (USA)	1295:1329	Commercial membrane Seprafilm (USA) was used as a reference sample.
34513064	4	86	theme	materials	826:834	arg1	Cytotoxicity					785:796	Cytotoxicity	785:796	Cytotoxicity of glycoluril-modified film materials derived from Na-CMC	785:854	Cytotoxicity of glycoluril-modified film materials derived from Na-CMC was studied by incubating cell cultures of 3T3-L1 mouse fibroblasts directly with extracts from films under study using a colorimetric test.
34513064	2	87	theme	modifier	415:422	arg1	solution					401:408	an aqueous solution	390:408	an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature	390:521	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	8	88	attach	derived	1427:1433	arg2	materials					1417:1425	film materials	1412:1425	film materials derived from Na-CMC	1412:1445	Results It was found that extracts obtained from film materials derived from Na-CMC modified with glycoluril at a concentration of 0.01 and 0.05 wt.
34513064	8	88	attach	derived	1427:1433	arg1	Na-CMC					1440:1445	Na-CMC	1440:1445	Na-CMC	1440:1445	Results It was found that extracts obtained from film materials derived from Na-CMC modified with glycoluril at a concentration of 0.01 and 0.05 wt.
34513064	5	89	theme	Wistar	1054:1059	arg1	rats					1061:1064	40 female Wistar rats	1044:1064	40 female Wistar rats	1044:1064	Their anti-adhesion effect was investigated on 40 female Wistar rats by modeling a flat adhesion by inducing abrasion of the cecum and suturing the deserosed surface of the abdominal wall anatomically opposite the abrasion area.
34513064	9	90	contain	had	1514:1516	arg1	%					1512:1512	%	1512:1512	%	1512:1512	% had no cytotoxic effect on the cell culture of mouse fibroblasts 3T3-L1.
34513064	9	90	contain	had	1514:1516	arg2	effect					1531:1536	no cytotoxic effect	1518:1536	no cytotoxic effect	1518:1536	% had no cytotoxic effect on the cell culture of mouse fibroblasts 3T3-L1.
34513064	5	91	theme	wall	1180:1183	arg1	surface					1155:1161	the deserosed surface	1141:1161	the deserosed surface of the abdominal wall anatomically opposite the abrasion area	1141:1223	Their anti-adhesion effect was investigated on 40 female Wistar rats by modeling a flat adhesion by inducing abrasion of the cecum and suturing the deserosed surface of the abdominal wall anatomically opposite the abrasion area.
34513064	8	92	theme	film	1412:1415	arg1	materials					1417:1425	film materials	1412:1425	film materials derived from Na-CMC	1412:1445	Results It was found that extracts obtained from film materials derived from Na-CMC modified with glycoluril at a concentration of 0.01 and 0.05 wt.
34513064	2	93	theme	sodium	347:352	arg1	cellulose					368:376	sodium carboxymethyl cellulose	347:376	sodium carboxymethyl cellulose (Na-CMC)	347:385	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	2	93	theme	sodium	347:352	arg1	Na-CMC					379:384	Na-CMC	379:384	Na-CMC	379:384	Materials and Methods The modified film materials were obtained by dissolving sodium carboxymethyl cellulose (Na-CMC) in an aqueous solution of a modifier (glycoluril) with subsequent homogenization and drying in a vacuum drying oven at room temperature.
34513064	4	94	theme	glycoluril-modified	801:819	arg1	materials					826:834	glycoluril-modified film materials	801:834	glycoluril-modified film materials derived from Na-CMC	801:854	Cytotoxicity of glycoluril-modified film materials derived from Na-CMC was studied by incubating cell cultures of 3T3-L1 mouse fibroblasts directly with extracts from films under study using a colorimetric test.
34709652	4	0	theme	gel	777:779	arg1	time					767:770	the transverse T22 relaxation time	737:770	the transverse T22 relaxation time of a gel	737:779	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	6	1	theme	emulsified	1121:1130	arg1	droplets					1136:1143	emulsified oil droplets	1121:1143	emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch	1121:1212	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	6	2	theme	oil	1132:1134	arg1	droplets					1136:1143	emulsified oil droplets	1121:1143	emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch	1121:1212	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	8	3	theme	starch	1539:1544	arg1	feasibility					1515:1525	the potential feasibility	1501:1525	the potential feasibility of modified starch and vegetable oil to improve the textural properties in comminuted meat products	1501:1625	The results suggest the potential feasibility of modified starch and vegetable oil to improve the textural properties in comminuted meat products.
34709652	1	4	theme	100 g kg-1	245:254	arg1	pre-emulsified					262:275	100 g kg-1 lipid pre-emulsified	245:275	100 g kg-1 lipid pre-emulsified	245:275	BACKGROUND Heat-induced composite gels were prepared with 20 g kg-1 myofibrillar protein (MP) sol, 20 g kg-1 modified starch and 100 g kg-1 lipid pre-emulsified by MP in 0.6 mol L-1 NaCl, at pH 6.2.
34709652	7	5	theme	CONCLUSION	1289:1298	arg1	lipid					1311:1315	CONCLUSION Emulsified lipid	1289:1315	CONCLUSION Emulsified lipid	1289:1315	CONCLUSION Emulsified lipid and modified starch have an important influence on the rheology and microstructure of MP gels, indicating the subtle interaction between starch, lipid and protein.
34709652	4	6	theme	relaxation	756:765	arg1	time					767:770	the transverse T22 relaxation time	737:770	the transverse T22 relaxation time of a gel	737:779	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	3	7	theme	gel	637:639	arg1	capacity					612:619	water holding capacity	598:619	water holding capacity (WHC)	598:625	RESULTS The addition of starch and lipid significantly improved the gel strength and water holding capacity (WHC) of the MP gel.
34709652	3	7	theme	gel	637:639	arg1	strength					585:592	gel strength	581:592	gel strength	581:592	RESULTS The addition of starch and lipid significantly improved the gel strength and water holding capacity (WHC) of the MP gel.
34709652	3	7	theme	gel	637:639	arg1	WHC					622:624	WHC	622:624	WHC	622:624	RESULTS The addition of starch and lipid significantly improved the gel strength and water holding capacity (WHC) of the MP gel.
34709652	6	8	theme	electron	1089:1096	arg1	microscopy					1098:1107	Environmental scanning electron microscopy	1066:1107	Environmental scanning electron microscopy	1066:1107	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	8	9	theme	vegetable	1550:1558	arg1	oil					1560:1562	vegetable oil	1550:1562	vegetable oil	1550:1562	The results suggest the potential feasibility of modified starch and vegetable oil to improve the textural properties in comminuted meat products.
34709652	2	10	from	effects	319:325	arg1	properties					428:437	texture properties	420:437	texture properties	420:437	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	2	10	from	effects	319:325	arg1	characterization					470:485	nuclear magnetic resonance characterization	443:485	nuclear magnetic resonance characterization	443:485	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	2	10	from	effects	319:325	arg1	rheology					410:417	the rheology	406:417	the rheology	406:417	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	8	11	from	properties	1588:1597	arg1	products					1618:1625	comminuted meat products	1602:1625	comminuted meat products	1602:1625	The results suggest the potential feasibility of modified starch and vegetable oil to improve the textural properties in comminuted meat products.
34709652	6	12	theme	Environmental	1066:1078	arg1	microscopy					1098:1107	Environmental scanning electron microscopy	1066:1107	Environmental scanning electron microscopy	1066:1107	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	1	13	theme	20 g kg-1	174:182	arg1	protein					197:203	20 g kg-1 myofibrillar protein	174:203	20 g kg-1 myofibrillar protein (MP) sol	174:212	BACKGROUND Heat-induced composite gels were prepared with 20 g kg-1 myofibrillar protein (MP) sol, 20 g kg-1 modified starch and 100 g kg-1 lipid pre-emulsified by MP in 0.6 mol L-1 NaCl, at pH 6.2.
34709652	1	13	theme	20 g kg-1	174:182	arg1	MP					206:207	MP	206:207	MP	206:207	BACKGROUND Heat-induced composite gels were prepared with 20 g kg-1 myofibrillar protein (MP) sol, 20 g kg-1 modified starch and 100 g kg-1 lipid pre-emulsified by MP in 0.6 mol L-1 NaCl, at pH 6.2.
34709652	2	14	theme	MP	490:491	arg1	gel					493:495	MP gel	490:495	MP gel	490:495	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	6	15	theme	protein	1170:1176	arg1	network					1178:1184	the protein network	1166:1184	the protein network	1166:1184	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	5	16	theme	MP	935:936	arg1	gel					938:940	MP gel	935:940	MP gel with starch and emulsified lard added at the same time	935:995	Moreover, MP gel with starch and emulsified lard added at the same time has the lowest T2 relaxation time, and also the best WHC of the gel.
34709652	1	17	theme	protein	197:203	arg1	sol					210:212	20 g kg-1 myofibrillar protein (MP) sol	174:212	20 g kg-1 myofibrillar protein (MP) sol	174:212	BACKGROUND Heat-induced composite gels were prepared with 20 g kg-1 myofibrillar protein (MP) sol, 20 g kg-1 modified starch and 100 g kg-1 lipid pre-emulsified by MP in 0.6 mol L-1 NaCl, at pH 6.2.
34709652	4	18	theme	composite	834:842	arg1	gel					844:846	the composite gel	830:846	the composite gel	830:846	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	8	19	theme	comminuted	1602:1611	arg1	products					1618:1625	comminuted meat products	1602:1625	comminuted meat products	1602:1625	The results suggest the potential feasibility of modified starch and vegetable oil to improve the textural properties in comminuted meat products.
34709652	4	20	dep	lower	857:861	arg1	time					882:885	the T22 relaxation time	863:885	the lower the T22 relaxation time	853:885	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	0	21	theme	potato	58:63	arg1	lard					73:76	lard	73:76	lard	73:76	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	0	21	theme	potato	58:63	arg1	oil					89:91	peanut oil	82:91	peanut oil	82:91	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	0	21	theme	potato	58:63	arg1	starch					65:70	esterified potato starch	47:70	esterified potato starch	47:70	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	4	22	theme	relaxation	871:880	arg1	time					882:885	the T22 relaxation time	863:885	the lower the T22 relaxation time	853:885	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	1	23	theme	Heat-induced	127:138	arg1	gels					150:153	BACKGROUND Heat-induced composite gels	116:153	BACKGROUND Heat-induced composite gels	116:153	BACKGROUND Heat-induced composite gels were prepared with 20 g kg-1 myofibrillar protein (MP) sol, 20 g kg-1 modified starch and 100 g kg-1 lipid pre-emulsified by MP in 0.6 mol L-1 NaCl, at pH 6.2.
34709652	2	24	theme	texture	420:426	arg1	properties					428:437	texture properties	420:437	texture properties	420:437	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	5	25	theme	same	987:990	arg1	time					992:995	the same time	983:995	the same time	983:995	Moreover, MP gel with starch and emulsified lard added at the same time has the lowest T2 relaxation time, and also the best WHC of the gel.
34709652	7	26	theme	MP	1403:1404	arg1	gels					1406:1409	MP gels	1403:1409	MP gels	1403:1409	CONCLUSION Emulsified lipid and modified starch have an important influence on the rheology and microstructure of MP gels, indicating the subtle interaction between starch, lipid and protein.
34709652	2	27	theme	magnetic	451:458	arg1	resonance					460:468	nuclear magnetic resonance	443:468	nuclear magnetic resonance characterization	443:485	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	4	28	theme	relaxation	658:667	arg1	time					669:672	the relaxation time	654:672	the relaxation time compared with the WHC tests	654:700	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	0	29	theme	Myofibrillar	0:11	arg1	gels					31:34	Myofibrillar protein composite gels	0:34	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.	0:114	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	1	30	theme	lipid	256:260	arg1	pre-emulsified					262:275	100 g kg-1 lipid pre-emulsified	245:275	100 g kg-1 lipid pre-emulsified	245:275	BACKGROUND Heat-induced composite gels were prepared with 20 g kg-1 myofibrillar protein (MP) sol, 20 g kg-1 modified starch and 100 g kg-1 lipid pre-emulsified by MP in 0.6 mol L-1 NaCl, at pH 6.2.
34709652	4	31	theme	composite	910:918	arg1	gel					920:922	composite gel	910:922	composite gel	910:922	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	0	32	theme	composite	21:29	arg1	gels					31:34	Myofibrillar protein composite gels	0:34	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.	0:114	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	3	33	theme	water	598:602	arg1	capacity					612:619	water holding capacity	598:619	water holding capacity (WHC)	598:625	RESULTS The addition of starch and lipid significantly improved the gel strength and water holding capacity (WHC) of the MP gel.
34709652	3	33	theme	water	598:602	arg1	WHC					622:624	WHC	622:624	WHC	622:624	RESULTS The addition of starch and lipid significantly improved the gel strength and water holding capacity (WHC) of the MP gel.
34709652	5	34	with	gel	938:940	arg1	lard					969:972	starch and emulsified lard	947:972	starch and emulsified lard added at the same time	947:995	Moreover, MP gel with starch and emulsified lard added at the same time has the lowest T2 relaxation time, and also the best WHC of the gel.
34709652	2	35	theme	emulsified	365:374	arg1	lipid					376:380	emulsified lipid	365:380	emulsified lipid (lard or peanut oil)	365:401	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	6	36	theme	droplet	1246:1252	arg1	size					1254:1257	the oil droplet size	1238:1257	the oil droplet size	1238:1257	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	4	37	theme	transverse	741:750	arg1	time					767:770	the transverse T22 relaxation time	737:770	the transverse T22 relaxation time of a gel	737:779	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	5	38	theme	lowest	1005:1010	arg1	time					1026:1029	the lowest T2 relaxation time	1001:1029	the lowest T2 relaxation time	1001:1029	Moreover, MP gel with starch and emulsified lard added at the same time has the lowest T2 relaxation time, and also the best WHC of the gel.
34709652	1	39	from	MP	280:281	arg1	NaCl					298:301	0.6 mol L-1 NaCl	286:301	0.6 mol L-1 NaCl	286:301	BACKGROUND Heat-induced composite gels were prepared with 20 g kg-1 myofibrillar protein (MP) sol, 20 g kg-1 modified starch and 100 g kg-1 lipid pre-emulsified by MP in 0.6 mol L-1 NaCl, at pH 6.2.
34709652	4	40	theme	variation	718:726	arg1	proportional					796:807	proportional	796:807	proportional	796:807	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	4	40	theme	variation	718:726	arg1	range					728:732	the variation range	714:732	the variation range of the transverse T22 relaxation time of a gel	714:779	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	2	41	theme	potato	341:346	arg1	EPS					356:358	EPS	356:358	EPS	356:358	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	2	41	theme	potato	341:346	arg1	starch					348:353	esterified potato starch	330:353	esterified potato starch (EPS)	330:359	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	5	42	theme	gel	1061:1063	arg1	WHC					1050:1052	the best WHC	1041:1052	the best WHC of the gel	1041:1063	Moreover, MP gel with starch and emulsified lard added at the same time has the lowest T2 relaxation time, and also the best WHC of the gel.
34709652	0	43	theme	esterified	47:56	arg1	lard					73:76	lard	73:76	lard	73:76	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	0	43	theme	esterified	47:56	arg1	oil					89:91	peanut oil	82:91	peanut oil	82:91	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	0	43	theme	esterified	47:56	arg1	starch					65:70	esterified potato starch	47:70	esterified potato starch	47:70	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	3	44	theme	MP	634:635	arg1	gel					637:639	the MP gel	630:639	the MP gel	630:639	RESULTS The addition of starch and lipid significantly improved the gel strength and water holding capacity (WHC) of the MP gel.
34709652	4	45	dep	better	892:897	arg1	WHC					903:905	the WHC	899:905	the better the WHC of composite gel	888:922	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	7	46	theme	Emulsified	1300:1309	arg1	lipid					1311:1315	CONCLUSION Emulsified lipid	1289:1315	CONCLUSION Emulsified lipid	1289:1315	CONCLUSION Emulsified lipid and modified starch have an important influence on the rheology and microstructure of MP gels, indicating the subtle interaction between starch, lipid and protein.
34709652	6	47	theme	MP	1281:1282	arg1	gel					1284:1286	thicker MP gel	1273:1286	thicker MP gel	1273:1286	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	5	48	theme	best	1045:1048	arg1	WHC					1050:1052	the best WHC	1041:1052	the best WHC of the gel	1041:1063	Moreover, MP gel with starch and emulsified lard added at the same time has the lowest T2 relaxation time, and also the best WHC of the gel.
34709652	3	49	dep	RESULTS	513:519	arg1	improved					568:575	improved	568:575	significantly improved the gel strength and water holding capacity (WHC) of the MP gel	554:639	RESULTS The addition of starch and lipid significantly improved the gel strength and water holding capacity (WHC) of the MP gel.
34709652	8	50	theme	modified	1530:1537	arg1	starch					1539:1544	modified starch	1530:1544	modified starch	1530:1544	The results suggest the potential feasibility of modified starch and vegetable oil to improve the textural properties in comminuted meat products.
34709652	7	51	contain	have	1337:1340	arg1	lipid					1311:1315	CONCLUSION Emulsified lipid	1289:1315	CONCLUSION Emulsified lipid	1289:1315	CONCLUSION Emulsified lipid and modified starch have an important influence on the rheology and microstructure of MP gels, indicating the subtle interaction between starch, lipid and protein.
34709652	7	51	contain	have	1337:1340	arg1	starch					1330:1335	starch	1330:1335	starch	1330:1335	CONCLUSION Emulsified lipid and modified starch have an important influence on the rheology and microstructure of MP gels, indicating the subtle interaction between starch, lipid and protein.
34709652	7	51	contain	have	1337:1340	arg2	influence					1355:1363	an important influence	1342:1363	an important influence	1342:1363	CONCLUSION Emulsified lipid and modified starch have an important influence on the rheology and microstructure of MP gels, indicating the subtle interaction between starch, lipid and protein.
34709652	4	52	theme	T22	752:754	arg1	time					767:770	the transverse T22 relaxation time	737:770	the transverse T22 relaxation time of a gel	737:779	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	6	53	from	gaps	1158:1161	arg1	starch					1207:1212	the gelatinized starch	1191:1212	the gelatinized starch	1191:1212	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	6	53	from	gaps	1158:1161	arg1	network					1178:1184	the protein network	1166:1184	the protein network	1166:1184	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	6	54	theme	scanning	1080:1087	arg1	microscopy					1098:1107	Environmental scanning electron microscopy	1066:1107	Environmental scanning electron microscopy	1066:1107	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	6	55	dep	droplets	1136:1143	arg1	embedded					1145:1152	embedded	1145:1152	embedded	1145:1152	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	4	56	theme	time	767:770	arg1	proportional					796:807	proportional	796:807	proportional	796:807	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	4	56	theme	time	767:770	arg1	range					728:732	the variation range	714:732	the variation range of the transverse T22 relaxation time of a gel	714:779	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	0	57	theme	gel	100:102	arg1	properties					104:113	the gel properties	96:113	the gel properties	96:113	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	8	58	theme	oil	1560:1562	arg1	feasibility					1515:1525	the potential feasibility	1501:1525	the potential feasibility of modified starch and vegetable oil to improve the textural properties in comminuted meat products	1501:1625	The results suggest the potential feasibility of modified starch and vegetable oil to improve the textural properties in comminuted meat products.
34709652	1	59	theme	myofibrillar	184:195	arg1	protein					197:203	20 g kg-1 myofibrillar protein	174:203	20 g kg-1 myofibrillar protein (MP) sol	174:212	BACKGROUND Heat-induced composite gels were prepared with 20 g kg-1 myofibrillar protein (MP) sol, 20 g kg-1 modified starch and 100 g kg-1 lipid pre-emulsified by MP in 0.6 mol L-1 NaCl, at pH 6.2.
34709652	1	59	theme	myofibrillar	184:195	arg1	MP					206:207	MP	206:207	MP	206:207	BACKGROUND Heat-induced composite gels were prepared with 20 g kg-1 myofibrillar protein (MP) sol, 20 g kg-1 modified starch and 100 g kg-1 lipid pre-emulsified by MP in 0.6 mol L-1 NaCl, at pH 6.2.
34709652	2	60	theme	gel	493:495	arg1	properties					428:437	texture properties	420:437	texture properties	420:437	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	2	60	theme	gel	493:495	arg1	characterization					470:485	nuclear magnetic resonance characterization	443:485	nuclear magnetic resonance characterization	443:485	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	2	60	theme	gel	493:495	arg1	rheology					410:417	the rheology	406:417	the rheology	406:417	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	3	61	theme	starch	537:542	arg1	addition					525:532	The addition	521:532	The addition of starch and lipid	521:552	RESULTS The addition of starch and lipid significantly improved the gel strength and water holding capacity (WHC) of the MP gel.
34709652	6	62	theme	gelatinized	1195:1205	arg1	starch					1207:1212	the gelatinized starch	1191:1212	the gelatinized starch	1191:1212	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	5	63	theme	starch	947:952	arg1	lard					969:972	starch and emulsified lard	947:972	starch and emulsified lard added at the same time	947:995	Moreover, MP gel with starch and emulsified lard added at the same time has the lowest T2 relaxation time, and also the best WHC of the gel.
34709652	8	64	theme	textural	1579:1586	arg1	properties					1588:1597	the textural properties	1575:1597	the textural properties in comminuted meat products	1575:1625	The results suggest the potential feasibility of modified starch and vegetable oil to improve the textural properties in comminuted meat products.
34709652	7	65	theme	subtle	1427:1432	arg1	interaction					1434:1444	the subtle interaction	1423:1444	the subtle interaction between starch, lipid and protein	1423:1478	CONCLUSION Emulsified lipid and modified starch have an important influence on the rheology and microstructure of MP gels, indicating the subtle interaction between starch, lipid and protein.
34709652	4	66	from	changes	812:818	arg1	better					892:897	better	892:897	better	892:897	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	4	66	from	changes	812:818	arg1	WHC					823:825	WHC	823:825	WHC of the composite gel	823:846	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	4	66	from	changes	812:818	arg1	lower					857:861	lower	857:861	lower	857:861	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	5	67	contain	has	997:999	arg1	gel					938:940	MP gel	935:940	MP gel with starch and emulsified lard added at the same time	935:995	Moreover, MP gel with starch and emulsified lard added at the same time has the lowest T2 relaxation time, and also the best WHC of the gel.
34709652	5	67	contain	has	997:999	arg2	time					1026:1029	the lowest T2 relaxation time	1001:1029	the lowest T2 relaxation time	1001:1029	Moreover, MP gel with starch and emulsified lard added at the same time has the lowest T2 relaxation time, and also the best WHC of the gel.
34709652	0	68	theme	starch	65:70	arg1	effect					37:42	effect	37:42	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.	0:114	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	3	69	theme	lipid	548:552	arg1	addition					525:532	The addition	521:532	The addition of starch and lipid	521:552	RESULTS The addition of starch and lipid significantly improved the gel strength and water holding capacity (WHC) of the MP gel.
34709652	8	70	theme	meat	1613:1616	arg1	products					1618:1625	comminuted meat products	1602:1625	comminuted meat products	1602:1625	The results suggest the potential feasibility of modified starch and vegetable oil to improve the textural properties in comminuted meat products.
34709652	1	71	theme	BACKGROUND	116:125	arg1	gels					150:153	BACKGROUND Heat-induced composite gels	116:153	BACKGROUND Heat-induced composite gels	116:153	BACKGROUND Heat-induced composite gels were prepared with 20 g kg-1 myofibrillar protein (MP) sol, 20 g kg-1 modified starch and 100 g kg-1 lipid pre-emulsified by MP in 0.6 mol L-1 NaCl, at pH 6.2.
34709652	7	72	theme	gels	1406:1409	arg1	microstructure					1385:1398	microstructure	1385:1398	microstructure	1385:1398	CONCLUSION Emulsified lipid and modified starch have an important influence on the rheology and microstructure of MP gels, indicating the subtle interaction between starch, lipid and protein.
34709652	7	72	theme	gels	1406:1409	arg1	rheology					1372:1379	rheology	1372:1379	rheology	1372:1379	CONCLUSION Emulsified lipid and modified starch have an important influence on the rheology and microstructure of MP gels, indicating the subtle interaction between starch, lipid and protein.
34709652	4	73	theme	gel	844:846	arg1	WHC					823:825	WHC	823:825	WHC of the composite gel	823:846	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	1	74	theme	composite	140:148	arg1	gels					150:153	BACKGROUND Heat-induced composite gels	116:153	BACKGROUND Heat-induced composite gels	116:153	BACKGROUND Heat-induced composite gels were prepared with 20 g kg-1 myofibrillar protein (MP) sol, 20 g kg-1 modified starch and 100 g kg-1 lipid pre-emulsified by MP in 0.6 mol L-1 NaCl, at pH 6.2.
34709652	4	75	theme	T22	867:869	arg1	time					882:885	the T22 relaxation time	863:885	the lower the T22 relaxation time	853:885	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	0	76	theme	peanut	82:87	arg1	oil					89:91	peanut oil	82:91	peanut oil	82:91	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	0	76	theme	peanut	82:87	arg1	starch					65:70	esterified potato starch	47:70	esterified potato starch	47:70	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	2	77	theme	resonance	460:468	arg1	characterization					470:485	nuclear magnetic resonance characterization	443:485	nuclear magnetic resonance characterization	443:485	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	5	78	theme	emulsified	958:967	arg1	lard					969:972	starch and emulsified lard	947:972	starch and emulsified lard added at the same time	947:995	Moreover, MP gel with starch and emulsified lard added at the same time has the lowest T2 relaxation time, and also the best WHC of the gel.
34709652	2	79	theme	nuclear	443:449	arg1	resonance					460:468	nuclear magnetic resonance	443:468	nuclear magnetic resonance characterization	443:485	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	0	80	from	effect	37:42	arg1	properties					104:113	the gel properties	96:113	the gel properties	96:113	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	4	81	theme	WHC	692:694	arg1	tests					696:700	the WHC tests	688:700	the WHC tests	688:700	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	0	82	theme	protein	13:19	arg1	gels					31:34	Myofibrillar protein composite gels	0:34	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.	0:114	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	2	83	theme	peanut	391:396	arg1	oil					398:400	peanut oil	391:400	peanut oil	391:400	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	2	84	theme	starch	348:353	arg1	effects					319:325	The effects	315:325	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel	315:495	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	9	85	theme	Chemical	1646:1653	arg1	Industry					1655:1662	Chemical Industry	1646:1662	Chemical Industry	1646:1662	© 2021 Society of Chemical Industry.
34709652	4	86	theme	time	669:672	arg1	Analysis					642:649	Analysis	642:649	Analysis of the relaxation time compared with the WHC tests	642:700	Analysis of the relaxation time compared with the WHC tests showed that the variation range of the transverse T22 relaxation time of a gel was positively proportional to changes in WHC of the composite gel, and the lower the T22 relaxation time, the better the WHC of composite gel.
34709652	2	87	theme	lipid	376:380	arg1	effects					319:325	The effects	315:325	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel	315:495	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	3	88	theme	gel	581:583	arg1	strength					585:592	gel strength	581:592	gel strength	581:592	RESULTS The addition of starch and lipid significantly improved the gel strength and water holding capacity (WHC) of the MP gel.
34709652	6	89	theme	oil	1242:1244	arg1	droplet					1246:1252	the oil droplet	1238:1252	the oil droplet size	1238:1257	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	1	90	theme	0.6 mol L-1	286:296	arg1	NaCl					298:301	0.6 mol L-1 NaCl	286:301	0.6 mol L-1 NaCl	286:301	BACKGROUND Heat-induced composite gels were prepared with 20 g kg-1 myofibrillar protein (MP) sol, 20 g kg-1 modified starch and 100 g kg-1 lipid pre-emulsified by MP in 0.6 mol L-1 NaCl, at pH 6.2.
34709652	2	91	dep	lipid	376:380	arg1	lard					383:386	lard	383:386	lard	383:386	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	2	91	dep	lipid	376:380	arg1	oil					398:400	peanut oil	391:400	peanut oil	391:400	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	5	92	theme	T2	1012:1013	arg1	time					1026:1029	the lowest T2 relaxation time	1001:1029	the lowest T2 relaxation time	1001:1029	Moreover, MP gel with starch and emulsified lard added at the same time has the lowest T2 relaxation time, and also the best WHC of the gel.
34709652	7	93	theme	important	1345:1353	arg1	influence					1355:1363	an important influence	1342:1363	an important influence	1342:1363	CONCLUSION Emulsified lipid and modified starch have an important influence on the rheology and microstructure of MP gels, indicating the subtle interaction between starch, lipid and protein.
34709652	0	94	dep	gels	31:34	arg1	effect					37:42	effect	37:42	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.	0:114	Myofibrillar protein composite gels: effect of esterified potato starch, lard and peanut oil on the gel properties.
34709652	3	95	theme	holding	604:610	arg1	capacity					612:619	water holding capacity	598:619	water holding capacity (WHC)	598:625	RESULTS The addition of starch and lipid significantly improved the gel strength and water holding capacity (WHC) of the MP gel.
34709652	3	95	theme	holding	604:610	arg1	WHC					622:624	WHC	622:624	WHC	622:624	RESULTS The addition of starch and lipid significantly improved the gel strength and water holding capacity (WHC) of the MP gel.
34709652	2	96	theme	esterified	330:339	arg1	EPS					356:358	EPS	356:358	EPS	356:358	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	2	96	theme	esterified	330:339	arg1	starch					348:353	esterified potato starch	330:353	esterified potato starch (EPS)	330:359	The effects of esterified potato starch (EPS) and emulsified lipid (lard or peanut oil) on the rheology, texture properties and nuclear magnetic resonance characterization of MP gel were evaluated.
34709652	3	97	dep	strength	585:592	arg1	the					577:579	the	577:579	the	577:579	RESULTS The addition of starch and lipid significantly improved the gel strength and water holding capacity (WHC) of the MP gel.
34709652	5	98	theme	relaxation	1015:1024	arg1	time					1026:1029	the lowest T2 relaxation time	1001:1029	the lowest T2 relaxation time	1001:1029	Moreover, MP gel with starch and emulsified lard added at the same time has the lowest T2 relaxation time, and also the best WHC of the gel.
34709652	6	99	theme	thicker	1273:1279	arg1	gel					1284:1286	thicker MP gel	1273:1286	thicker MP gel	1273:1286	Environmental scanning electron microscopy showed that emulsified oil droplets embedded the gaps in the protein network, and the gelatinized starch contributed to restrict the oil droplet size, resulting in thicker MP gel.
34709652	8	100	theme	potential	1505:1513	arg1	feasibility					1515:1525	the potential feasibility	1501:1525	the potential feasibility of modified starch and vegetable oil to improve the textural properties in comminuted meat products	1501:1625	The results suggest the potential feasibility of modified starch and vegetable oil to improve the textural properties in comminuted meat products.
34709652	7	101	dep	rheology	1372:1379	arg1	the					1368:1370	the	1368:1370	the	1368:1370	CONCLUSION Emulsified lipid and modified starch have an important influence on the rheology and microstructure of MP gels, indicating the subtle interaction between starch, lipid and protein.
32972156	6	0	with	GPs	707:709	arg1	compound					690:697	the compound itself	686:704	the compound itself	686:704	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	6	1	theme	GPs-diplacone	656:668	arg1	diplacone					758:766	diplacone	758:766	diplacone	758:766	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	6	1	theme	GPs-diplacone	656:668	arg1	GPs					750:752	GPs	750:752	GPs	750:752	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	6	1	theme	GPs-diplacone	656:668	arg1	composites					670:679	GPs-diplacone composites	656:679	GPs-diplacone composites with the compound itself	656:704	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	0	2	theme	flavonoid	84:92	arg1	diplacone					94:102	flavonoid diplacone	84:102	flavonoid diplacone	84:102	Anti-inflammatory potential of composites of yeast glucan particles and geranylated flavonoid diplacone.
32972156	8	3	dep	factor	1068:1073	arg1	#					1076:1076	#	1076:1076	#	1076:1076	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	3	4	theme	antioxidant	247:257	arg1	properties					259:268	anti-inflammatory and antioxidant properties	225:268	anti-inflammatory and antioxidant properties	225:268	(Paulowniaceae) with anti-inflammatory and antioxidant properties, nevertheless showing high lipophilicity and low solubility in water.
32972156	1	5	from	tomentosa	178:186	arg1	lated					157:161	a flavanone iso- lated	140:161	a flavanone iso- lated from Paulownia tomentosa	140:186	Geranylated flavanone diplacone is a flavanone iso- lated from Paulownia tomentosa (Thunb.)
32972156	8	6	dep	factors	1052:1058	arg1	AP-1					1121:1124	AP-1	1121:1124	AP-1	1121:1124	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	6	dep	factors	1052:1058	arg1	B					1081:1081	B	1081:1081	B (NF-&#954;B)	1081:1094	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	6	dep	factors	1052:1058	arg1	B					1093:1093	NF-&#954;B	1084:1093	NF-&#954;B	1084:1093	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	6	dep	factors	1052:1058	arg1	factor					1068:1073	nuclear factor	1060:1073	pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1)	1021:1125	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	6	dep	factors	1052:1058	arg1	protein					1110:1116	activator protein 1	1100:1118	activator protein 1 (AP-1)	1100:1125	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	6	dep	factors	1052:1058	arg1	factors					1052:1058	pro-inflammatory transcription factors nuclear factor &#954	1021:1079	pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1)	1021:1125	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	7	7	theme	human	818:822	arg1	monocytes					833:841	human leukemic monocytes	818:841	human leukemic monocytes	818:841	The cell line THP1-XBlueTM-MD2-CD14 derived from human leukemic monocytes was stimulated with lipopolysaccharide (LPS) from Escherichia coli to trigger inflammatory reaction.
32972156	3	8	from	lipophilicity	297:309	arg1	water					333:337	water	333:337	water	333:337	(Paulowniaceae) with anti-inflammatory and antioxidant properties, nevertheless showing high lipophilicity and low solubility in water.
32972156	6	9	with	composites	670:679	arg1	compound					690:697	the compound itself	686:704	the compound itself	686:704	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	7	10	theme	inflammatory	921:932	arg1	reaction					934:941	inflammatory reaction	921:941	inflammatory reaction	921:941	The cell line THP1-XBlueTM-MD2-CD14 derived from human leukemic monocytes was stimulated with lipopolysaccharide (LPS) from Escherichia coli to trigger inflammatory reaction.
32972156	5	11	dep	yeast	477:481	arg1	cerevisiae					498:507	Saccharomyces cerevisiae	484:507	yeast (Saccharomyces cerevisiae) leading to hollow shells consisting of &#946;-(13)/&#946;-(16) glucan mainly	477:585	GPs are prepared by intensive washing of yeast (Saccharomyces cerevisiae) leading to hollow shells consisting of &#946;-(13)/&#946;-(16) glucan mainly.
32972156	7	12	theme	leukemic	824:831	arg1	monocytes					833:841	human leukemic monocytes	818:841	human leukemic monocytes	818:841	The cell line THP1-XBlueTM-MD2-CD14 derived from human leukemic monocytes was stimulated with lipopolysaccharide (LPS) from Escherichia coli to trigger inflammatory reaction.
32972156	3	13	theme	anti-inflammatory	225:241	arg1	properties					259:268	anti-inflammatory and antioxidant properties	225:268	anti-inflammatory and antioxidant properties	225:268	(Paulowniaceae) with anti-inflammatory and antioxidant properties, nevertheless showing high lipophilicity and low solubility in water.
32972156	1	14	dep	lated	157:161	arg1	Thunb					189:193	Thunb	189:193	Thunb	189:193	Geranylated flavanone diplacone is a flavanone iso- lated from Paulownia tomentosa (Thunb.)
32972156	8	15	theme	activator	1100:1108	arg1	protein					1110:1116	activator protein 1	1100:1118	activator protein 1 (AP-1)	1100:1125	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	15	theme	activator	1100:1108	arg1	AP-1					1121:1124	AP-1	1121:1124	AP-1	1121:1124	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	15	theme	activator	1100:1108	arg1	factors					1052:1058	pro-inflammatory transcription factors nuclear factor &#954	1021:1079	pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1)	1021:1125	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	16	theme	pro-inflammatory	1021:1036	arg1	protein					1110:1116	activator protein 1	1100:1118	activator protein 1 (AP-1)	1100:1125	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	16	theme	pro-inflammatory	1021:1036	arg1	B					1081:1081	B	1081:1081	B (NF-&#954;B)	1081:1094	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	16	theme	pro-inflammatory	1021:1036	arg1	factors					1052:1058	pro-inflammatory transcription factors nuclear factor &#954	1021:1079	pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1)	1021:1125	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	6	17	theme	mixture	739:745	arg1	potential					643:651	anti-inflammatory potential	625:651	anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone	625:766	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	0	18	theme	glucan	51:56	arg1	particles					58:66	yeast glucan particles	45:66	yeast glucan particles	45:66	Anti-inflammatory potential of composites of yeast glucan particles and geranylated flavonoid diplacone.
32972156	6	19	theme	physical	730:737	arg1	mixture					739:745	the physical mixture	726:745	the physical mixture of GPs and diplacone	726:766	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	6	20	with	mixture	739:745	arg1	compound					690:697	the compound itself	686:704	the compound itself	686:704	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	5	21	theme	hollow	521:526	arg1	shells					528:533	hollow shells	521:533	hollow shells consisting of &#946;-(13)/&#946;-(16) glucan mainly	521:585	GPs are prepared by intensive washing of yeast (Saccharomyces cerevisiae) leading to hollow shells consisting of &#946;-(13)/&#946;-(16) glucan mainly.
32972156	8	22	theme	factors	1052:1058	arg1	activity					1009:1016	the activity	1005:1016	the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1)	1005:1125	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	23	with	composites	948:957	arg1	diplacone					971:979	diplacone	971:979	diplacone	971:979	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	0	24	theme	Anti-inflammatory	0:16	arg1	potential					18:26	Anti-inflammatory potential	0:26	Anti-inflammatory potential of composites of yeast glucan particles	0:66	Anti-inflammatory potential of composites of yeast glucan particles and geranylated flavonoid diplacone.
32972156	8	25	theme	transcription	1038:1050	arg1	protein					1110:1116	activator protein 1	1100:1118	activator protein 1 (AP-1)	1100:1125	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	25	theme	transcription	1038:1050	arg1	B					1081:1081	B	1081:1081	B (NF-&#954;B)	1081:1094	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	25	theme	transcription	1038:1050	arg1	factors					1052:1058	pro-inflammatory transcription factors nuclear factor &#954	1021:1079	pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1)	1021:1125	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	5	26	theme	/&	560:561	arg1	#					562:562	-(13)/&#946	555:565	#	562:562	GPs are prepared by intensive washing of yeast (Saccharomyces cerevisiae) leading to hollow shells consisting of &#946;-(13)/&#946;-(16) glucan mainly.
32972156	1	27	theme	Geranylated	105:115	arg1	diplacone					127:135	Geranylated flavanone diplacone	105:135	Geranylated flavanone diplacone	105:135	Geranylated flavanone diplacone is a flavanone iso- lated from Paulownia tomentosa (Thunb.)
32972156	0	28	theme	composites	31:40	arg1	potential					18:26	Anti-inflammatory potential	0:26	Anti-inflammatory potential of composites of yeast glucan particles	0:66	Anti-inflammatory potential of composites of yeast glucan particles and geranylated flavonoid diplacone.
32972156	4	29	theme	glucan	412:417	arg1	GPs					430:432	GPs	430:432	GPs	430:432	Diplacone was therefore used as a model molecule for incorporation into glucan particles (GPs).
32972156	4	29	theme	glucan	412:417	arg1	particles					419:427	glucan particles	412:427	glucan particles (GPs)	412:433	Diplacone was therefore used as a model molecule for incorporation into glucan particles (GPs).
32972156	1	30	theme	flavanone	117:125	arg1	diplacone					127:135	Geranylated flavanone diplacone	105:135	Geranylated flavanone diplacone	105:135	Geranylated flavanone diplacone is a flavanone iso- lated from Paulownia tomentosa (Thunb.)
32972156	7	31	theme	cell	773:776	arg1	line					778:781	The cell line THP1-XBlueTM-MD2-CD14	769:803	The cell line THP1-XBlueTM-MD2-CD14 derived from human leukemic monocytes	769:841	The cell line THP1-XBlueTM-MD2-CD14 derived from human leukemic monocytes was stimulated with lipopolysaccharide (LPS) from Escherichia coli to trigger inflammatory reaction.
32972156	3	32	theme	low	315:317	arg1	solubility					319:328	low solubility	315:328	low solubility	315:328	(Paulowniaceae) with anti-inflammatory and antioxidant properties, nevertheless showing high lipophilicity and low solubility in water.
32972156	6	33	theme	study	604:608	arg1	aim					592:594	The aim	588:594	The aim of this study	588:608	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	4	34	used	used	364:367	arg2	Diplacone					340:348	Diplacone	340:348	Diplacone	340:348	Diplacone was therefore used as a model molecule for incorporation into glucan particles (GPs).
32972156	4	34	used	used	364:367	arg2	molecule					380:387	a model molecule	372:387	a model molecule for incorporation into glucan particles (GPs)	372:433	Diplacone was therefore used as a model molecule for incorporation into glucan particles (GPs).
32972156	0	35	theme	yeast	45:49	arg1	particles					58:66	yeast glucan particles	45:66	yeast glucan particles	45:66	Anti-inflammatory potential of composites of yeast glucan particles and geranylated flavonoid diplacone.
32972156	3	36	theme	high	292:295	arg1	lipophilicity					297:309	high lipophilicity	292:309	high lipophilicity	292:309	(Paulowniaceae) with anti-inflammatory and antioxidant properties, nevertheless showing high lipophilicity and low solubility in water.
32972156	8	37	theme	nuclear	1060:1066	arg1	factor					1068:1073	nuclear factor	1060:1073	pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1)	1021:1125	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	4	38	theme	a model	372:378	arg1	Diplacone					340:348	Diplacone	340:348	Diplacone	340:348	Diplacone was therefore used as a model molecule for incorporation into glucan particles (GPs).
32972156	4	38	theme	a model	372:378	arg1	molecule					380:387	a model molecule	372:387	a model molecule for incorporation into glucan particles (GPs)	372:433	Diplacone was therefore used as a model molecule for incorporation into glucan particles (GPs).
32972156	0	39	theme	particles	58:66	arg1	composites					31:40	composites	31:40	composites of yeast glucan particles	31:66	Anti-inflammatory potential of composites of yeast glucan particles and geranylated flavonoid diplacone.
32972156	0	39	theme	particles	58:66	arg1	particles					58:66	yeast glucan particles	45:66	yeast glucan particles	45:66	Anti-inflammatory potential of composites of yeast glucan particles and geranylated flavonoid diplacone.
32972156	3	40	dep	showing	284:290	arg1	Paulowniaceae					205:217	Paulowniaceae	205:217	Paulowniaceae	205:217	(Paulowniaceae) with anti-inflammatory and antioxidant properties, nevertheless showing high lipophilicity and low solubility in water.
32972156	7	41	attach	derived	805:811	arg1	monocytes					833:841	human leukemic monocytes	818:841	human leukemic monocytes	818:841	The cell line THP1-XBlueTM-MD2-CD14 derived from human leukemic monocytes was stimulated with lipopolysaccharide (LPS) from Escherichia coli to trigger inflammatory reaction.
32972156	7	41	attach	derived	805:811	arg2	line					778:781	The cell line THP1-XBlueTM-MD2-CD14	769:803	The cell line THP1-XBlueTM-MD2-CD14 derived from human leukemic monocytes	769:841	The cell line THP1-XBlueTM-MD2-CD14 derived from human leukemic monocytes was stimulated with lipopolysaccharide (LPS) from Escherichia coli to trigger inflammatory reaction.
32972156	1	42	theme	a flavanone	140:150	arg1	lated					157:161	a flavanone iso- lated	140:161	a flavanone iso- lated from Paulownia tomentosa	140:186	Geranylated flavanone diplacone is a flavanone iso- lated from Paulownia tomentosa (Thunb.)
32972156	8	43	theme	GPs	962:964	arg1	GPs					962:964	GPs	962:964	GPs	962:964	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	43	theme	GPs	962:964	arg1	composites					948:957	The composites	944:957	The composites of GPs with diplacone	944:979	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	6	44	theme	GPs	750:752	arg1	diplacone					758:766	diplacone	758:766	diplacone	758:766	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	6	44	theme	GPs	750:752	arg1	GPs					750:752	GPs	750:752	GPs	750:752	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	6	44	theme	GPs	750:752	arg1	composites					670:679	GPs-diplacone composites	656:679	GPs-diplacone composites with the compound itself	656:704	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	6	44	theme	GPs	750:752	arg1	mixture					739:745	the physical mixture	726:745	the physical mixture of GPs and diplacone	726:766	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	6	44	theme	GPs	750:752	arg1	GPs					707:709	GPs	707:709	GPs themselves	707:720	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	1	45	theme	iso-	152:155	arg1	lated					157:161	a flavanone iso- lated	140:161	a flavanone iso- lated from Paulownia tomentosa	140:186	Geranylated flavanone diplacone is a flavanone iso- lated from Paulownia tomentosa (Thunb.)
32972156	6	46	theme	composites	670:679	arg1	potential					643:651	anti-inflammatory potential	625:651	anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone	625:766	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	3	47	from	solubility	319:328	arg1	water					333:337	water	333:337	water	333:337	(Paulowniaceae) with anti-inflammatory and antioxidant properties, nevertheless showing high lipophilicity and low solubility in water.
32972156	6	48	theme	GPs	707:709	arg1	potential					643:651	anti-inflammatory potential	625:651	anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone	625:766	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	6	49	theme	anti-inflammatory	625:641	arg1	potential					643:651	anti-inflammatory potential	625:651	anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone	625:766	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	8	50	theme	#	1088:1088	arg1	B					1081:1081	B	1081:1081	B (NF-&#954;B)	1081:1094	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	50	theme	#	1088:1088	arg1	B					1093:1093	NF-&#954;B	1084:1093	NF-&#954;B	1084:1093	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	6	51	theme	diplacone	758:766	arg1	diplacone					758:766	diplacone	758:766	diplacone	758:766	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	6	51	theme	diplacone	758:766	arg1	GPs					750:752	GPs	750:752	GPs	750:752	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	6	51	theme	diplacone	758:766	arg1	composites					670:679	GPs-diplacone composites	656:679	GPs-diplacone composites with the compound itself	656:704	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	6	51	theme	diplacone	758:766	arg1	mixture					739:745	the physical mixture	726:745	the physical mixture of GPs and diplacone	726:766	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	6	51	theme	diplacone	758:766	arg1	GPs					707:709	GPs	707:709	GPs themselves	707:720	The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone.
32972156	7	52	from	coli	905:908	arg1	LPS					883:885	LPS	883:885	LPS	883:885	The cell line THP1-XBlueTM-MD2-CD14 derived from human leukemic monocytes was stimulated with lipopolysaccharide (LPS) from Escherichia coli to trigger inflammatory reaction.
32972156	7	52	from	coli	905:908	arg1	lipopolysaccharide					863:880	lipopolysaccharide	863:880	lipopolysaccharide (LPS) from Escherichia coli	863:908	The cell line THP1-XBlueTM-MD2-CD14 derived from human leukemic monocytes was stimulated with lipopolysaccharide (LPS) from Escherichia coli to trigger inflammatory reaction.
32972156	5	53	theme	yeast	477:481	arg1	intensive					456:464	intensive	456:464	intensive	456:464	GPs are prepared by intensive washing of yeast (Saccharomyces cerevisiae) leading to hollow shells consisting of &#946;-(13)/&#946;-(16) glucan mainly.
32972156	8	54	theme	NF-&	1084:1087	arg1	B					1081:1081	B	1081:1081	B (NF-&#954;B)	1081:1094	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	8	54	theme	NF-&	1084:1087	arg1	B					1093:1093	NF-&#954;B	1084:1093	NF-&#954;B	1084:1093	The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor &#954;B (NF-&#954;B) and activator protein 1 (AP-1).
32972156	5	55	theme	&	549:549	arg1	#					550:550	&#946	549:553	&#946	549:553	GPs are prepared by intensive washing of yeast (Saccharomyces cerevisiae) leading to hollow shells consisting of &#946;-(13)/&#946;-(16) glucan mainly.
32197613	6	0	theme	barrier	899:905	arg1	function					907:914	skin barrier function	894:914	skin barrier function	894:914	Thus, it was hypothesized that this formulation could improve clinical disease and skin barrier function in patients with AD.
32197613	7	1	dep	control	1035:1041	arg1	n = 6					1044:1048	n = 6	1044:1048	n = 6; no treatment	1044:1062	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	15	2	theme	atopic	2326:2331	arg1	patients					2333:2340	atopic patients	2326:2340	atopic patients	2326:2340	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	2	3	theme	ceramides	282:290	arg1	metabolism					224:233	metabolism	224:233	metabolism	224:233	This impairment is related to altered composition and metabolism of epidermal sphingolipids and a deficiency of ceramides.
32197613	2	3	theme	ceramides	282:290	arg1	composition					208:218	altered composition	200:218	altered composition	200:218	This impairment is related to altered composition and metabolism of epidermal sphingolipids and a deficiency of ceramides.
32197613	2	3	theme	ceramides	282:290	arg1	deficiency					268:277	a deficiency	266:277	a deficiency of ceramides	266:290	This impairment is related to altered composition and metabolism of epidermal sphingolipids and a deficiency of ceramides.
32197613	12	4	theme	polyunsaturated	1852:1866	arg1	acids					1874:1878	SC polyunsaturated fatty acids	1849:1878	SC polyunsaturated fatty acids	1849:1878	Compared to baseline, significant increases in CADESI (P = 0.0003) and PVAS (P = 0.041) were observed only in the control group, and SC polyunsaturated fatty acids increased significantly only with treatment (P = 0.039).
32197613	6	5	theme	clinical	873:880	arg1	disease					882:888	clinical disease	873:888	clinical disease	873:888	Thus, it was hypothesized that this formulation could improve clinical disease and skin barrier function in patients with AD.
32197613	9	6	theme	water	1373:1377	arg1	loss					1379:1382	transepidermal water loss	1358:1382	transepidermal water loss	1358:1382	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	6	7	with	patients	919:926	arg1	AD					933:934	AD	933:934	AD	933:934	Thus, it was hypothesized that this formulation could improve clinical disease and skin barrier function in patients with AD.
32197613	5	8	theme	high	631:634	arg1	sphingomyelin					647:659	sphingomyelin	647:659	sphingomyelin	647:659	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	5	8	theme	high	631:634	arg1	precursor					664:672	a precursor	662:672	a precursor of ceramides	662:685	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	5	8	theme	high	631:634	arg1	amounts					636:642	high amounts	631:642	high amounts of sphingomyelin, a precursor of ceramides	631:685	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	4	9	with	dogs	512:515	arg1	AD					522:523	AD	522:523	AD	522:523	This study aimed to evaluate the effects of a novel topical treatment consisting of sphingolipids and GAGs extracts in dogs with AD.
32197613	12	10	from	increases	1750:1758	arg1	P = 0.0003					1771:1780	P = 0.0003	1771:1780	P = 0.0003	1771:1780	Compared to baseline, significant increases in CADESI (P = 0.0003) and PVAS (P = 0.041) were observed only in the control group, and SC polyunsaturated fatty acids increased significantly only with treatment (P = 0.039).
32197613	12	10	from	increases	1750:1758	arg1	P = 0.041					1793:1801	P = 0.041	1793:1801	P = 0.041	1793:1801	Compared to baseline, significant increases in CADESI (P = 0.0003) and PVAS (P = 0.041) were observed only in the control group, and SC polyunsaturated fatty acids increased significantly only with treatment (P = 0.039).
32197613	15	11	from	CONCLUSIONS	2122:2132	arg1	dogs					2151:2154	dogs	2151:2154	dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts	2151:2252	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	15	11	from	CONCLUSIONS	2122:2132	arg1	study					2142:2146	this study	2137:2146	this study	2137:2146	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	7	12	dep	treatment	1068:1076	arg1	n = 6					1079:1083	n = 6	1079:1083	n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks	1079:1140	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	15	13	theme	sphingomyelin-rich	2202:2219	arg1	sphingolipids					2221:2233	sphingomyelin-rich sphingolipids	2202:2233	sphingomyelin-rich sphingolipids	2202:2233	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	1	14	theme	key	134:136	arg1	role					138:141	a key role	132:141	a key role	132:141	BACKGROUND Skin barrier dysfunction plays a key role in atopic dermatitis (AD).
32197613	7	15	dep	n = 6	1044:1048	arg1	treatment					1054:1062	no treatment	1051:1062	n = 6; no treatment	1044:1062	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	7	16	theme	atopic	983:988	arg1	dogs					997:1000	Twelve house dust mite (HDM) allergic atopic beagle dogs	945:1000	Twelve house dust mite (HDM) allergic atopic beagle dogs	945:1000	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	9	17	theme	pruritus	1401:1408	arg1	severity					1389:1396	severity	1389:1396	severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes	1389:1478	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	9	17	theme	pruritus	1401:1408	arg1	measurement					1343:1353	measurement	1343:1353	measurement of transepidermal water loss	1343:1382	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	9	17	theme	pruritus	1401:1408	arg1	function					1333:1340	Skin barrier function	1320:1340	Skin barrier function	1320:1340	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	15	18	theme	new	2167:2169	arg1	formulation					2179:2189	a new topical formulation	2165:2189	a new topical formulation containing sphingomyelin-rich sphingolipids	2165:2233	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	5	19	theme	sphingomyelin	647:659	arg1	sphingomyelin					647:659	sphingomyelin	647:659	sphingomyelin	647:659	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	5	19	theme	sphingomyelin	647:659	arg1	precursor					664:672	a precursor	662:672	a precursor of ceramides	662:685	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	5	19	theme	sphingomyelin	647:659	arg1	amounts					636:642	high amounts	631:642	high amounts of sphingomyelin, a precursor of ceramides	631:685	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	15	20	dep	attenuated	2254:2263	arg1	used					2380:2383	used	2380:2383	used as monotherapy in certain cases	2380:2415	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	15	20	dep	attenuated	2254:2263	arg1	supporting					2304:2313	supporting	2304:2313	supporting its use in atopic patients	2304:2340	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	15	20	dep	attenuated	2254:2263	arg1	treatment					2367:2375	an adjunctive treatment	2353:2375	an adjunctive treatment	2353:2375	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	7	21	dep	RESULTS	937:943	arg1	randomized					1007:1016	randomized	1007:1016	were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks)	1002:1141	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	11	22	theme	corneum	1646:1652	arg1	analyses					1670:1677	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses	1593:1677	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses	1593:1677	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses were done at baseline and at week 8.
32197613	5	23	theme	ceramides	677:685	arg1	sphingomyelin					647:659	sphingomyelin	647:659	sphingomyelin	647:659	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	5	23	theme	ceramides	677:685	arg1	precursor					664:672	a precursor	662:672	a precursor of ceramides	662:685	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	9	24	theme	visual	1425:1430	arg1	scale					1439:1443	visual analog scale	1425:1443	visual analog scale	1425:1443	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	8	25	theme	canine	1244:1249	arg1	dermatitis					1258:1267	the canine atopic dermatitis	1240:1267	the canine atopic dermatitis	1240:1267	Dogs were challenged with allergen twice weekly and the severity of dermatitis was scored using the canine atopic dermatitis and extent severity index (CADESI-03) once weekly.
32197613	0	26	theme	atopic	71:76	arg1	dermatitis					78:87	canine atopic dermatitis	64:87	canine atopic dermatitis	64:87	Topical treatment with SPHINGOLIPIDS and GLYCOSAMINOGLYCANS for canine atopic dermatitis.
32197613	2	27	theme	epidermal	238:246	arg1	sphingolipids					248:260	epidermal sphingolipids	238:260	epidermal sphingolipids	238:260	This impairment is related to altered composition and metabolism of epidermal sphingolipids and a deficiency of ceramides.
32197613	7	28	theme	dust	958:961	arg1	dogs					997:1000	Twelve house dust mite (HDM) allergic atopic beagle dogs	945:1000	Twelve house dust mite (HDM) allergic atopic beagle dogs	945:1000	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	11	29	theme	lipidomics	1659:1668	arg1	analyses					1670:1677	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses	1593:1677	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses	1593:1677	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses were done at baseline and at week 8.
32197613	5	30	theme	ceramides	747:755	arg1	synthesis					734:742	endogenous synthesis	723:742	endogenous synthesis of ceramides	723:755	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	5	31	theme	tested	572:577	arg1	products					579:586	previously tested products	561:586	previously tested products	561:586	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	5	32	from	products	579:586	arg1	different					546:554	different	546:554	different	546:554	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	8	33	theme	extent	1273:1278	arg1	CADESI-03					1296:1304	CADESI-03	1296:1304	CADESI-03	1296:1304	Dogs were challenged with allergen twice weekly and the severity of dermatitis was scored using the canine atopic dermatitis and extent severity index (CADESI-03) once weekly.
32197613	8	33	theme	extent	1273:1278	arg1	index					1289:1293	extent severity index	1273:1293	extent severity index (CADESI-03) once weekly	1273:1317	Dogs were challenged with allergen twice weekly and the severity of dermatitis was scored using the canine atopic dermatitis and extent severity index (CADESI-03) once weekly.
32197613	3	34	from	useful	361:366	arg1	management					375:384	the management	371:384	the management of AD	371:390	Glycosaminoglycans (GAGs), and especially hyaluronic acid, could be useful in the management of AD.
32197613	9	35	theme	pruritus	1456:1463	arg1	severity					1389:1396	severity	1389:1396	severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes	1389:1478	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	9	35	theme	pruritus	1456:1463	arg1	measurement					1343:1353	measurement	1343:1353	measurement of transepidermal water loss	1343:1382	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	9	35	theme	pruritus	1456:1463	arg1	function					1333:1340	Skin barrier function	1320:1340	Skin barrier function	1320:1340	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	4	36	theme	novel	439:443	arg1	treatment					453:461	a novel topical treatment	437:461	a novel topical treatment consisting of sphingolipids and GAGs extracts in dogs with AD	437:523	This study aimed to evaluate the effects of a novel topical treatment consisting of sphingolipids and GAGs extracts in dogs with AD.
32197613	1	37	theme	BACKGROUND	90:99	arg1	dysfunction					114:124	BACKGROUND Skin barrier dysfunction	90:124	BACKGROUND Skin barrier dysfunction	90:124	BACKGROUND Skin barrier dysfunction plays a key role in atopic dermatitis (AD).
32197613	13	38	contain	had	1974:1976	arg2	CADESI					2000:2005	a significantly lower CADESI	1978:2005	a significantly lower CADESI after 1 week (P = 0.0078)	1978:2031	Compared to control, treatment group had a significantly lower CADESI after 1 week (P = 0.0078) and a significantly lower PVAS after 8 weeks (P = 0.0448).
32197613	13	38	contain	had	1974:1976	arg2	PVAS					2059:2062	a significantly lower PVAS	2037:2062	a significantly lower PVAS after 8 weeks (P = 0.0448)	2037:2089	Compared to control, treatment group had a significantly lower CADESI after 1 week (P = 0.0078) and a significantly lower PVAS after 8 weeks (P = 0.0448).
32197613	13	38	contain	had	1974:1976	arg1	group					1968:1972	treatment group	1958:1972	treatment group	1958:1972	Compared to control, treatment group had a significantly lower CADESI after 1 week (P = 0.0078) and a significantly lower PVAS after 8 weeks (P = 0.0448).
32197613	4	39	theme	treatment	453:461	arg1	effects					426:432	the effects	422:432	the effects of a novel topical treatment consisting of sphingolipids and GAGs extracts in dogs with AD	422:523	This study aimed to evaluate the effects of a novel topical treatment consisting of sphingolipids and GAGs extracts in dogs with AD.
32197613	0	40	theme	Topical	0:6	arg1	treatment					8:16	Topical treatment	0:16	Topical treatment with SPHINGOLIPIDS and GLYCOSAMINOGLYCANS for canine atopic dermatitis	0:87	Topical treatment with SPHINGOLIPIDS and GLYCOSAMINOGLYCANS for canine atopic dermatitis.
32197613	1	41	theme	barrier	106:112	arg1	dysfunction					114:124	BACKGROUND Skin barrier dysfunction	90:124	BACKGROUND Skin barrier dysfunction	90:124	BACKGROUND Skin barrier dysfunction plays a key role in atopic dermatitis (AD).
32197613	10	42	theme	group	1575:1579	arg1	allocation					1581:1590	group allocation	1575:1590	group allocation	1575:1590	Assessments were done by personnel unaware of group allocation.
32197613	1	43	theme	atopic	146:151	arg1	dermatitis					153:162	atopic dermatitis	146:162	atopic dermatitis (AD)	146:167	BACKGROUND Skin barrier dysfunction plays a key role in atopic dermatitis (AD).
32197613	1	43	theme	atopic	146:151	arg1	AD					165:166	AD	165:166	AD	165:166	BACKGROUND Skin barrier dysfunction plays a key role in atopic dermatitis (AD).
32197613	11	44	theme	blood	1602:1606	arg1	count					1608:1612	Complete blood count	1593:1612	Complete blood count	1593:1612	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses were done at baseline and at week 8.
32197613	15	45	dep	supporting	2304:2313	arg1	either					2343:2348	either	2343:2348	either	2343:2348	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	7	46	theme	topical	1086:1092	arg1	sphingolipids					1094:1106	topical sphingolipids	1086:1106	topical sphingolipids	1086:1106	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	5	47	theme	lamellar-related	773:788	arg1	structures					790:799	lamellar-related structures	773:799	lamellar-related structures	773:799	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	4	48	dep	sphingolipids	477:489	arg1	extracts					500:507	extracts	500:507	extracts	500:507	This study aimed to evaluate the effects of a novel topical treatment consisting of sphingolipids and GAGs extracts in dogs with AD.
32197613	11	49	theme	biochemistry	1621:1632	arg1	analyses					1670:1677	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses	1593:1677	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses	1593:1677	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses were done at baseline and at week 8.
32197613	12	50	located	observed	1809:1816	arg2	increases					1750:1758	significant increases	1738:1758	significant increases in CADESI (P = 0.0003) and PVAS (P = 0.041)	1738:1802	Compared to baseline, significant increases in CADESI (P = 0.0003) and PVAS (P = 0.041) were observed only in the control group, and SC polyunsaturated fatty acids increased significantly only with treatment (P = 0.039).
32197613	12	50	located	observed	1809:1816	arg1	group					1838:1842	the control group	1826:1842	the control group	1826:1842	Compared to baseline, significant increases in CADESI (P = 0.0003) and PVAS (P = 0.041) were observed only in the control group, and SC polyunsaturated fatty acids increased significantly only with treatment (P = 0.039).
32197613	15	51	with	dogs	2151:2154	arg1	GAGs					2240:2243	GAGs	2240:2243	GAGs	2240:2243	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	15	51	with	dogs	2151:2154	arg1	formulation					2179:2189	a new topical formulation	2165:2189	a new topical formulation containing sphingomyelin-rich sphingolipids	2165:2233	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	15	51	with	dogs	2151:2154	arg1	AD					2161:2162	AD	2161:2162	AD	2161:2162	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	9	52	theme	Skin	1320:1323	arg1	function					1333:1340	Skin barrier function	1320:1340	Skin barrier function	1320:1340	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	12	53	theme	fatty	1868:1872	arg1	acids					1874:1878	SC polyunsaturated fatty acids	1849:1878	SC polyunsaturated fatty acids	1849:1878	Compared to baseline, significant increases in CADESI (P = 0.0003) and PVAS (P = 0.041) were observed only in the control group, and SC polyunsaturated fatty acids increased significantly only with treatment (P = 0.039).
32197613	6	54	from	function	907:914	arg1	patients					919:926	patients	919:926	patients with AD	919:934	Thus, it was hypothesized that this formulation could improve clinical disease and skin barrier function in patients with AD.
32197613	4	55	from	GAGs	495:498	arg1	dogs					512:515	dogs	512:515	dogs with AD	512:523	This study aimed to evaluate the effects of a novel topical treatment consisting of sphingolipids and GAGs extracts in dogs with AD.
32197613	13	56	theme	lower	1994:1998	arg1	CADESI					2000:2005	a significantly lower CADESI	1978:2005	a significantly lower CADESI after 1 week (P = 0.0078)	1978:2031	Compared to control, treatment group had a significantly lower CADESI after 1 week (P = 0.0078) and a significantly lower PVAS after 8 weeks (P = 0.0448).
32197613	6	57	theme	skin	894:897	arg1	function					907:914	skin barrier function	894:914	skin barrier function	894:914	Thus, it was hypothesized that this formulation could improve clinical disease and skin barrier function in patients with AD.
32197613	5	58	contain	contained	621:629	arg2	sphingomyelin					647:659	sphingomyelin	647:659	sphingomyelin	647:659	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	5	58	contain	contained	621:629	arg1	extract					613:619	the sphingolipid extract	596:619	the sphingolipid extract	596:619	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	5	58	contain	contained	621:629	arg2	precursor					664:672	a precursor	662:672	a precursor of ceramides	662:685	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	5	58	contain	contained	621:629	arg2	amounts					636:642	high amounts	631:642	high amounts of sphingomyelin, a precursor of ceramides	631:685	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	4	59	from	sphingolipids	477:489	arg1	dogs					512:515	dogs	512:515	dogs with AD	512:523	This study aimed to evaluate the effects of a novel topical treatment consisting of sphingolipids and GAGs extracts in dogs with AD.
32197613	6	60	from	disease	882:888	arg1	patients					919:926	patients	919:926	patients with AD	919:934	Thus, it was hypothesized that this formulation could improve clinical disease and skin barrier function in patients with AD.
32197613	5	61	theme	sphingolipid	600:611	arg1	extract					613:619	the sphingolipid extract	596:619	the sphingolipid extract	596:619	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	9	62	theme	transepidermal	1358:1371	arg1	loss					1379:1382	transepidermal water loss	1358:1382	transepidermal water loss	1358:1382	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	12	63	theme	SC	1849:1850	arg1	acids					1874:1878	SC polyunsaturated fatty acids	1849:1878	SC polyunsaturated fatty acids	1849:1878	Compared to baseline, significant increases in CADESI (P = 0.0003) and PVAS (P = 0.041) were observed only in the control group, and SC polyunsaturated fatty acids increased significantly only with treatment (P = 0.039).
32197613	9	64	theme	loss	1379:1382	arg1	severity					1389:1396	severity	1389:1396	severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes	1389:1478	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	9	64	theme	loss	1379:1382	arg1	measurement					1343:1353	measurement	1343:1353	measurement of transepidermal water loss	1343:1382	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	9	64	theme	loss	1379:1382	arg1	function					1333:1340	Skin barrier function	1320:1340	Skin barrier function	1320:1340	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	2	65	theme	altered	200:206	arg1	composition					208:218	altered composition	200:218	altered composition	200:218	This impairment is related to altered composition and metabolism of epidermal sphingolipids and a deficiency of ceramides.
32197613	12	66	theme	control	1830:1836	arg1	group					1838:1842	the control group	1826:1842	the control group	1826:1842	Compared to baseline, significant increases in CADESI (P = 0.0003) and PVAS (P = 0.041) were observed only in the control group, and SC polyunsaturated fatty acids increased significantly only with treatment (P = 0.039).
32197613	15	67	from	use	2319:2321	arg1	patients					2333:2340	atopic patients	2326:2340	atopic patients	2326:2340	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	7	68	theme	beagle	990:995	arg1	dogs					997:1000	Twelve house dust mite (HDM) allergic atopic beagle dogs	945:1000	Twelve house dust mite (HDM) allergic atopic beagle dogs	945:1000	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	8	69	theme	dermatitis	1212:1221	arg1	severity					1200:1207	the severity	1196:1207	the severity of dermatitis	1196:1221	Dogs were challenged with allergen twice weekly and the severity of dermatitis was scored using the canine atopic dermatitis and extent severity index (CADESI-03) once weekly.
32197613	15	70	theme	topical	2171:2177	arg1	formulation					2179:2189	a new topical formulation	2165:2189	a new topical formulation containing sphingomyelin-rich sphingolipids	2165:2233	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	7	71	theme	allergic	974:981	arg1	dogs					997:1000	Twelve house dust mite (HDM) allergic atopic beagle dogs	945:1000	Twelve house dust mite (HDM) allergic atopic beagle dogs	945:1000	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	9	72	dep	pruritus	1416:1423	arg1	both					1411:1414	both	1411:1414	both	1411:1414	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	5	73	theme	endogenous	723:732	arg1	synthesis					734:742	endogenous synthesis	723:742	endogenous synthesis of ceramides	723:755	This formulation is different from previously tested products because the sphingolipid extract contained high amounts of sphingomyelin, a precursor of ceramides, and this has been shown to enhance endogenous synthesis of ceramides and to increase lamellar-related structures in vitro.
32197613	13	74	theme	treatment	1958:1966	arg1	group					1968:1972	treatment group	1958:1972	treatment group	1958:1972	Compared to control, treatment group had a significantly lower CADESI after 1 week (P = 0.0078) and a significantly lower PVAS after 8 weeks (P = 0.0448).
32197613	2	75	theme	sphingolipids	248:260	arg1	metabolism					224:233	metabolism	224:233	metabolism	224:233	This impairment is related to altered composition and metabolism of epidermal sphingolipids and a deficiency of ceramides.
32197613	2	75	theme	sphingolipids	248:260	arg1	composition					208:218	altered composition	200:218	altered composition	200:218	This impairment is related to altered composition and metabolism of epidermal sphingolipids and a deficiency of ceramides.
32197613	2	75	theme	sphingolipids	248:260	arg1	deficiency					268:277	a deficiency	266:277	a deficiency of ceramides	266:290	This impairment is related to altered composition and metabolism of epidermal sphingolipids and a deficiency of ceramides.
32197613	9	76	theme	analog	1432:1437	arg1	scale					1439:1443	visual analog scale	1425:1443	visual analog scale	1425:1443	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	3	77	theme	hyaluronic	335:344	arg1	acid					346:349	hyaluronic acid	335:349	hyaluronic acid	335:349	Glycosaminoglycans (GAGs), and especially hyaluronic acid, could be useful in the management of AD.
32197613	11	78	theme	stratum	1638:1644	arg1	corneum					1646:1652	stratum corneum	1638:1652	stratum corneum (SC)	1638:1657	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses were done at baseline and at week 8.
32197613	11	78	theme	stratum	1638:1644	arg1	SC					1655:1656	SC	1655:1656	SC	1655:1656	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses were done at baseline and at week 8.
32197613	7	79	theme	mite	963:966	arg1	dust					958:961	Twelve house dust mite	945:966	Twelve house dust mite (HDM) allergic atopic beagle dogs	945:1000	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	7	79	theme	mite	963:966	arg1	HDM					969:971	HDM	969:971	HDM	969:971	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	9	80	theme	[PVAS	1445:1449	arg1	pruritus					1416:1423	pruritus	1416:1423	pruritus visual analog scale [PVAS	1416:1449	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	8	81	theme	atopic	1251:1256	arg1	dermatitis					1258:1267	the canine atopic dermatitis	1240:1267	the canine atopic dermatitis	1240:1267	Dogs were challenged with allergen twice weekly and the severity of dermatitis was scored using the canine atopic dermatitis and extent severity index (CADESI-03) once weekly.
32197613	15	82	theme	clinical	2269:2276	arg1	worsening					2278:2286	the clinical worsening	2265:2286	the clinical worsening induced by HDM	2265:2301	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	7	83	theme	house	952:956	arg1	dust					958:961	Twelve house dust mite	945:966	Twelve house dust mite (HDM) allergic atopic beagle dogs	945:1000	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	7	83	theme	house	952:956	arg1	HDM					969:971	HDM	969:971	HDM	969:971	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	4	84	theme	topical	445:451	arg1	treatment					453:461	a novel topical treatment	437:461	a novel topical treatment consisting of sphingolipids and GAGs extracts in dogs with AD	437:523	This study aimed to evaluate the effects of a novel topical treatment consisting of sphingolipids and GAGs extracts in dogs with AD.
32197613	15	85	theme	adjunctive	2356:2365	arg1	treatment					2367:2375	an adjunctive treatment	2353:2375	an adjunctive treatment	2353:2375	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	9	86	theme	timed	1465:1469	arg1	episodes					1471:1478	timed episodes	1465:1478	timed episodes	1465:1478	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	7	87	dep	n = 6	1079:1083	arg1	GAGs					1112:1115	GAGs	1112:1115	GAGs	1112:1115	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	7	87	dep	n = 6	1079:1083	arg1	sphingolipids					1094:1106	topical sphingolipids	1086:1106	topical sphingolipids	1086:1106	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	8	88	theme	severity	1280:1287	arg1	CADESI-03					1296:1304	CADESI-03	1296:1304	CADESI-03	1296:1304	Dogs were challenged with allergen twice weekly and the severity of dermatitis was scored using the canine atopic dermatitis and extent severity index (CADESI-03) once weekly.
32197613	8	88	theme	severity	1280:1287	arg1	index					1289:1293	extent severity index	1273:1293	extent severity index (CADESI-03) once weekly	1273:1317	Dogs were challenged with allergen twice weekly and the severity of dermatitis was scored using the canine atopic dermatitis and extent severity index (CADESI-03) once weekly.
32197613	3	89	from	management	375:384	arg1	useful					361:366	useful	361:366	useful	361:366	Glycosaminoglycans (GAGs), and especially hyaluronic acid, could be useful in the management of AD.
32197613	1	90	theme	Skin	101:104	arg1	dysfunction					114:124	BACKGROUND Skin barrier dysfunction	90:124	BACKGROUND Skin barrier dysfunction	90:124	BACKGROUND Skin barrier dysfunction plays a key role in atopic dermatitis (AD).
32197613	12	91	theme	significant	1738:1748	arg1	increases					1750:1758	significant increases	1738:1758	significant increases in CADESI (P = 0.0003) and PVAS (P = 0.041)	1738:1802	Compared to baseline, significant increases in CADESI (P = 0.0003) and PVAS (P = 0.041) were observed only in the control group, and SC polyunsaturated fatty acids increased significantly only with treatment (P = 0.039).
32197613	15	92	contain	containing	2191:2200	arg2	sphingolipids					2221:2233	sphingomyelin-rich sphingolipids	2202:2233	sphingomyelin-rich sphingolipids	2202:2233	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	15	92	contain	containing	2191:2200	arg1	formulation					2179:2189	a new topical formulation	2165:2189	a new topical formulation containing sphingomyelin-rich sphingolipids	2165:2233	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	11	93	theme	Complete	1593:1600	arg1	count					1608:1612	Complete blood count	1593:1612	Complete blood count	1593:1612	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses were done at baseline and at week 8.
32197613	10	94	theme	personnel	1554:1562	arg1	unaware					1564:1570	personnel unaware	1554:1570	personnel unaware of group allocation	1554:1590	Assessments were done by personnel unaware of group allocation.
32197613	0	95	theme	canine	64:69	arg1	dermatitis					78:87	canine atopic dermatitis	64:87	canine atopic dermatitis	64:87	Topical treatment with SPHINGOLIPIDS and GLYCOSAMINOGLYCANS for canine atopic dermatitis.
32197613	15	96	dep	AD	2161:2162	arg1	extracts					2245:2252	extracts	2245:2252	extracts	2245:2252	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	3	97	theme	AD	389:390	arg1	management					375:384	the management	371:384	the management of AD	371:390	Glycosaminoglycans (GAGs), and especially hyaluronic acid, could be useful in the management of AD.
32197613	11	98	theme	serum	1615:1619	arg1	biochemistry					1621:1632	serum biochemistry	1615:1632	serum biochemistry	1615:1632	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses were done at baseline and at week 8.
32197613	0	99	with	treatment	8:16	arg1	GLYCOSAMINOGLYCANS					41:58	GLYCOSAMINOGLYCANS	41:58	GLYCOSAMINOGLYCANS	41:58	Topical treatment with SPHINGOLIPIDS and GLYCOSAMINOGLYCANS for canine atopic dermatitis.
32197613	0	99	with	treatment	8:16	arg1	SPHINGOLIPIDS					23:35	SPHINGOLIPIDS	23:35	SPHINGOLIPIDS	23:35	Topical treatment with SPHINGOLIPIDS and GLYCOSAMINOGLYCANS for canine atopic dermatitis.
32197613	13	100	theme	lower	2053:2057	arg1	PVAS					2059:2062	a significantly lower PVAS	2037:2062	a significantly lower PVAS after 8 weeks (P = 0.0448)	2037:2089	Compared to control, treatment group had a significantly lower CADESI after 1 week (P = 0.0078) and a significantly lower PVAS after 8 weeks (P = 0.0448).
32197613	11	101	theme	count	1608:1612	arg1	analyses					1670:1677	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses	1593:1677	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses	1593:1677	Complete blood count, serum biochemistry and stratum corneum (SC) lipidomics analyses were done at baseline and at week 8.
32197613	9	102	dep	pruritus	1401:1408	arg1	pruritus					1416:1423	pruritus	1416:1423	pruritus visual analog scale [PVAS	1416:1449	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	9	102	dep	pruritus	1401:1408	arg1	episodes					1471:1478	timed episodes	1465:1478	timed episodes	1465:1478	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	10	103	theme	allocation	1581:1590	arg1	unaware					1564:1570	personnel unaware	1554:1570	personnel unaware of group allocation	1554:1590	Assessments were done by personnel unaware of group allocation.
32197613	15	104	theme	certain	2403:2409	arg1	cases					2411:2415	certain cases	2403:2415	certain cases	2403:2415	CONCLUSIONS In this study in dogs with AD, a new topical formulation containing sphingomyelin-rich sphingolipids plus GAGs extracts attenuated the clinical worsening induced by HDM, supporting its use in atopic patients, either as an adjunctive treatment or used as monotherapy in certain cases.
32197613	9	105	theme	treatment	1518:1526	arg1	0					1498:1498	0	1498:1498	0	1498:1498	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	9	105	theme	treatment	1518:1526	arg1	treatment					1518:1526	treatment	1518:1526	treatment	1518:1526	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
32197613	7	106	dep	groups	1027:1032	arg1	groups					1027:1032	two groups	1023:1032	two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks)	1023:1141	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	7	106	dep	groups	1027:1032	arg1	treatment					1068:1076	treatment	1068:1076	treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks)	1068:1141	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	7	106	dep	groups	1027:1032	arg1	control					1035:1041	control	1035:1041	control (n = 6; no treatment)	1035:1063	RESULTS Twelve house dust mite (HDM) allergic atopic beagle dogs were randomized into two groups: control (n = 6; no treatment) or treatment (n = 6; topical sphingolipids and GAGs twice weekly for 8 weeks).
32197613	9	107	theme	barrier	1325:1331	arg1	function					1333:1340	Skin barrier function	1320:1340	Skin barrier function	1320:1340	Skin barrier function (measurement of transepidermal water loss) and severity of pruritus (both pruritus visual analog scale [PVAS] and pruritus timed episodes) were assessed at 0, 4 and 8 weeks of treatment.
34141584	1	0	theme	genetic	151:157	arg1	diseases					159:166	genetic diseases	151:166	genetic diseases affecting the glycosylation of proteins	151:206	Congenital disorders of glycosylation (CDG) constitute an ever-growing group of genetic diseases affecting the glycosylation of proteins.
34141584	6	1	theme	transferrin	943:953	arg1	profile					969:975	a particular transferrin glycosylation profile	930:975	a particular transferrin glycosylation profile	930:975	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	6	2	theme	flight	1065:1070	arg1	spectrometry					1089:1100	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry	1011:1100	spectrometry	1089:1100	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	3	3	theme	intellectual	339:350	arg1	deficiency					352:361	intellectual deficiency	339:361	intellectual deficiency	339:361	MAN1B1-CDG is a CDG with nonspecific clinical symptoms such as intellectual deficiency and developmental delay.
34141584	4	4	theme	trace-level	537:547	arg1	accumulation					549:560	the trace-level accumulation	533:560	the trace-level accumulation of defective glycan structures	533:591	Although up to 40 affected individuals were described so far, its final diagnosis is not straightforward using common biochemical methods due to the trace-level accumulation of defective glycan structures.
34141584	6	5	theme	unexplained	860:870	arg1	disability					885:894	unexplained intellectual disability	860:894	unexplained intellectual disability	860:894	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	1	6	theme	diseases	159:166	arg1	group					142:146	an ever-growing group	126:146	an ever-growing group of genetic diseases affecting the glycosylation of proteins	126:206	Congenital disorders of glycosylation (CDG) constitute an ever-growing group of genetic diseases affecting the glycosylation of proteins.
34141584	1	6	theme	diseases	159:166	arg1	diseases					159:166	genetic diseases	151:166	genetic diseases affecting the glycosylation of proteins	151:206	Congenital disorders of glycosylation (CDG) constitute an ever-growing group of genetic diseases affecting the glycosylation of proteins.
34141584	6	7	theme	of	1062:1063	arg1	spectrometry					1089:1100	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry	1011:1100	spectrometry	1089:1100	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	7	8	theme	biochemical	1299:1309	arg1	features					1311:1318	particular biochemical features	1288:1318	particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects	1288:1391	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	6	9	theme	glycosylation	955:967	arg1	profile					969:975	a particular transferrin glycosylation profile	930:975	a particular transferrin glycosylation profile	930:975	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	7	10	theme	new	1196:1198	arg1	hypersialorrhea					1258:1272	hypersialorrhea	1258:1272	hypersialorrhea	1258:1272	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	7	10	theme	new	1196:1198	arg1	variants					1211:1218	new pathogenic variants	1196:1218	new pathogenic variants	1196:1218	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	5	11	theme	unreported	626:635	arg1	individuals					648:658	three unreported MAN1B1-CDG individuals	620:658	three unreported MAN1B1-CDG individuals	620:658	In this study, we present three unreported MAN1B1-CDG individuals and propose a decision tree to reach diagnosis using a panel of techniques ranging from exome sequencing to gel electrophoresis and mass spectrometry.
34141584	6	12	theme	time	1057:1060	arg1	spectrometry					1089:1100	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry	1011:1100	spectrometry	1089:1100	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	6	13	theme	laser	1027:1031	arg1	desorption/ionization					1033:1053	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry	1011:1100	desorption/ionization	1033:1053	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	4	14	theme	common	499:504	arg1	methods					518:524	common biochemical methods	499:524	common biochemical methods	499:524	Although up to 40 affected individuals were described so far, its final diagnosis is not straightforward using common biochemical methods due to the trace-level accumulation of defective glycan structures.
34141584	1	15	gly	glycosylation	182:194	arg1	proteins					199:206	proteins	199:206	proteins	199:206	Congenital disorders of glycosylation (CDG) constitute an ever-growing group of genetic diseases affecting the glycosylation of proteins.
34141584	5	16	theme	MAN1B1-CDG	637:646	arg1	individuals					648:658	three unreported MAN1B1-CDG individuals	620:658	three unreported MAN1B1-CDG individuals	620:658	In this study, we present three unreported MAN1B1-CDG individuals and propose a decision tree to reach diagnosis using a panel of techniques ranging from exome sequencing to gel electrophoresis and mass spectrometry.
34141584	7	17	theme	glycoprotein-specific	1349:1369	arg1	defects					1385:1391	potential glycoprotein-specific glycosylation defects	1339:1391	potential glycoprotein-specific glycosylation defects	1339:1391	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	3	18	theme	developmental	367:379	arg1	delay					381:385	developmental delay	367:385	developmental delay	367:385	MAN1B1-CDG is a CDG with nonspecific clinical symptoms such as intellectual deficiency and developmental delay.
34141584	6	19	theme	particular	932:941	arg1	profile					969:975	a particular transferrin glycosylation profile	930:975	a particular transferrin glycosylation profile	930:975	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	1	20	theme	Congenital	71:80	arg1	disorders					82:90	Congenital disorders	71:90	Congenital disorders of glycosylation (CDG)	71:113	Congenital disorders of glycosylation (CDG) constitute an ever-growing group of genetic diseases affecting the glycosylation of proteins.
34141584	7	21	theme	particular	1288:1297	arg1	features					1311:1318	particular biochemical features	1288:1318	particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects	1288:1391	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	6	22	theme	MAN1B1-CDG	829:838	arg1	occurrence					815:824	The occurrence	811:824	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile,	811:976	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	5	23	theme	gel	768:770	arg1	electrophoresis					772:786	gel electrophoresis	768:786	gel electrophoresis	768:786	In this study, we present three unreported MAN1B1-CDG individuals and propose a decision tree to reach diagnosis using a panel of techniques ranging from exome sequencing to gel electrophoresis and mass spectrometry.
34141584	4	24	theme	biochemical	506:516	arg1	methods					518:524	common biochemical methods	499:524	common biochemical methods	499:524	Although up to 40 affected individuals were described so far, its final diagnosis is not straightforward using common biochemical methods due to the trace-level accumulation of defective glycan structures.
34141584	7	25	theme	MAN1B1-CDG	1323:1332	arg1	features					1311:1318	particular biochemical features	1288:1318	particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects	1288:1391	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	6	26	theme	serum	1154:1158	arg1	N-glycans					1160:1168	endo-β-acetylglucosaminidase H-released serum N-glycans	1114:1168	endo-β-acetylglucosaminidase H-released serum N-glycans	1114:1168	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	6	27	theme	desorption/ionization	1033:1053	arg1	analysis					1102:1109	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis	1011:1109	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans	1011:1168	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	5	28	theme	decision	674:681	arg1	tree					683:686	a decision tree	672:686	a decision tree to reach diagnosis using a panel of techniques ranging from exome sequencing to gel electrophoresis and mass spectrometry	672:808	In this study, we present three unreported MAN1B1-CDG individuals and propose a decision tree to reach diagnosis using a panel of techniques ranging from exome sequencing to gel electrophoresis and mass spectrometry.
34141584	4	29	theme	affected	406:413	arg1	individuals					415:425	up to 40 affected individuals	397:425	up to 40 affected individuals	397:425	Although up to 40 affected individuals were described so far, its final diagnosis is not straightforward using common biochemical methods due to the trace-level accumulation of defective glycan structures.
34141584	1	30	theme	glycosylation	95:107	arg1	disorders					82:90	Congenital disorders	71:90	Congenital disorders of glycosylation (CDG)	71:113	Congenital disorders of glycosylation (CDG) constitute an ever-growing group of genetic diseases affecting the glycosylation of proteins.
34141584	6	31	theme	H-released	1143:1152	arg1	N-glycans					1160:1168	endo-β-acetylglucosaminidase H-released serum N-glycans	1114:1168	endo-β-acetylglucosaminidase H-released serum N-glycans	1114:1168	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	0	32	theme	new	18:20	arg1	individuals					22:32	Three new individuals	12:32	Three new individuals	12:32	MAN1B1-CDG: Three new individuals and associated biochemical profiles.
34141584	4	33	theme	structures	582:591	arg1	accumulation					549:560	the trace-level accumulation	533:560	the trace-level accumulation of defective glycan structures	533:591	Although up to 40 affected individuals were described so far, its final diagnosis is not straightforward using common biochemical methods due to the trace-level accumulation of defective glycan structures.
34141584	5	34	theme	techniques	724:733	arg1	panel					715:719	a panel	713:719	a panel of techniques ranging from exome sequencing to gel electrophoresis and mass spectrometry	713:808	In this study, we present three unreported MAN1B1-CDG individuals and propose a decision tree to reach diagnosis using a panel of techniques ranging from exome sequencing to gel electrophoresis and mass spectrometry.
34141584	7	35	with	features	1311:1318	arg1	defects					1385:1391	potential glycoprotein-specific glycosylation defects	1339:1391	potential glycoprotein-specific glycosylation defects	1339:1391	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	1	36	theme	proteins	199:206	arg1	glycosylation					182:194	the glycosylation	178:194	the glycosylation of proteins	178:206	Congenital disorders of glycosylation (CDG) constitute an ever-growing group of genetic diseases affecting the glycosylation of proteins.
34141584	6	37	theme	assisted	1018:1025	arg1	desorption/ionization					1033:1053	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry	1011:1100	desorption/ionization	1033:1053	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	6	38	from	occurrence	815:824	arg1	patients					843:850	patients	843:850	patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile,	843:976	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	7	39	theme	glycosylation	1371:1383	arg1	defects					1385:1391	potential glycoprotein-specific glycosylation defects	1339:1391	potential glycoprotein-specific glycosylation defects	1339:1391	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	7	40	dep	reporting	1186:1194	arg1	addition					1174:1181	addition	1174:1181	addition	1174:1181	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	6	41	theme	matrix	1011:1016	arg1	desorption/ionization					1033:1053	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry	1011:1100	desorption/ionization	1033:1053	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	2	42	theme	severe	246:251	arg1	disorders					265:273	severe multisystem disorders	246:273	severe multisystem disorders	246:273	CDG individuals usually present with severe multisystem disorders.
34141584	3	43	with	CDG	292:294	arg1	deficiency					352:361	intellectual deficiency	339:361	intellectual deficiency	339:361	MAN1B1-CDG is a CDG with nonspecific clinical symptoms such as intellectual deficiency and developmental delay.
34141584	3	43	with	CDG	292:294	arg1	delay					381:385	developmental delay	367:385	developmental delay	367:385	MAN1B1-CDG is a CDG with nonspecific clinical symptoms such as intellectual deficiency and developmental delay.
34141584	3	43	with	CDG	292:294	arg1	symptoms					322:329	nonspecific clinical symptoms	301:329	nonspecific clinical symptoms such as intellectual deficiency and developmental delay	301:385	MAN1B1-CDG is a CDG with nonspecific clinical symptoms such as intellectual deficiency and developmental delay.
34141584	5	44	theme	exome	748:752	arg1	sequencing					754:763	exome sequencing	748:763	exome sequencing	748:763	In this study, we present three unreported MAN1B1-CDG individuals and propose a decision tree to reach diagnosis using a panel of techniques ranging from exome sequencing to gel electrophoresis and mass spectrometry.
34141584	6	45	theme	spectrometry	1089:1100	arg1	analysis					1102:1109	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis	1011:1109	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans	1011:1168	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	0	46	theme	biochemical	49:59	arg1	profiles					61:68	associated biochemical profiles	38:68	associated biochemical profiles	38:68	MAN1B1-CDG: Three new individuals and associated biochemical profiles.
34141584	5	47	theme	mass	792:795	arg1	spectrometry					797:808	mass spectrometry	792:808	mass spectrometry	792:808	In this study, we present three unreported MAN1B1-CDG individuals and propose a decision tree to reach diagnosis using a panel of techniques ranging from exome sequencing to gel electrophoresis and mass spectrometry.
34141584	0	48	theme	associated	38:47	arg1	profiles					61:68	associated biochemical profiles	38:68	associated biochemical profiles	38:68	MAN1B1-CDG: Three new individuals and associated biochemical profiles.
34141584	4	49	theme	glycan	575:580	arg1	structures					582:591	defective glycan structures	565:591	defective glycan structures	565:591	Although up to 40 affected individuals were described so far, its final diagnosis is not straightforward using common biochemical methods due to the trace-level accumulation of defective glycan structures.
34141584	6	50	theme	development	900:910	arg1	delay					912:916	development delay	900:916	development delay	900:916	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	0	51	dep	individuals	22:32	arg1	MAN1B1-CDG					0:9	MAN1B1-CDG	0:9	MAN1B1-CDG	0:9	MAN1B1-CDG: Three new individuals and associated biochemical profiles.
34141584	7	52	theme	additional	1224:1233	arg1	signs					1244:1248	additional clinical signs	1224:1248	additional clinical signs	1224:1248	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	7	52	theme	additional	1224:1233	arg1	hypersialorrhea					1258:1272	hypersialorrhea	1258:1272	hypersialorrhea	1258:1272	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	4	53	theme	defective	565:573	arg1	structures					582:591	defective glycan structures	565:591	defective glycan structures	565:591	Although up to 40 affected individuals were described so far, its final diagnosis is not straightforward using common biochemical methods due to the trace-level accumulation of defective glycan structures.
34141584	3	54	theme	nonspecific	301:311	arg1	deficiency					352:361	intellectual deficiency	339:361	intellectual deficiency	339:361	MAN1B1-CDG is a CDG with nonspecific clinical symptoms such as intellectual deficiency and developmental delay.
34141584	3	54	theme	nonspecific	301:311	arg1	delay					381:385	developmental delay	367:385	developmental delay	367:385	MAN1B1-CDG is a CDG with nonspecific clinical symptoms such as intellectual deficiency and developmental delay.
34141584	3	54	theme	nonspecific	301:311	arg1	symptoms					322:329	nonspecific clinical symptoms	301:329	nonspecific clinical symptoms such as intellectual deficiency and developmental delay	301:385	MAN1B1-CDG is a CDG with nonspecific clinical symptoms such as intellectual deficiency and developmental delay.
34141584	2	55	theme	CDG	209:211	arg1	individuals					213:223	CDG individuals	209:223	CDG individuals	209:223	CDG individuals usually present with severe multisystem disorders.
34141584	7	56	theme	clinical	1235:1242	arg1	signs					1244:1248	additional clinical signs	1224:1248	additional clinical signs	1224:1248	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	7	56	theme	clinical	1235:1242	arg1	hypersialorrhea					1258:1272	hypersialorrhea	1258:1272	hypersialorrhea	1258:1272	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	4	57	dep	40	403:404	arg1	to					400:401	to	400:401	to	400:401	Although up to 40 affected individuals were described so far, its final diagnosis is not straightforward using common biochemical methods due to the trace-level accumulation of defective glycan structures.
34141584	6	58	theme	mass	1084:1087	arg1	spectrometry					1089:1100	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry	1011:1100	spectrometry	1089:1100	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	3	59	theme	clinical	313:320	arg1	deficiency					352:361	intellectual deficiency	339:361	intellectual deficiency	339:361	MAN1B1-CDG is a CDG with nonspecific clinical symptoms such as intellectual deficiency and developmental delay.
34141584	3	59	theme	clinical	313:320	arg1	delay					381:385	developmental delay	367:385	developmental delay	367:385	MAN1B1-CDG is a CDG with nonspecific clinical symptoms such as intellectual deficiency and developmental delay.
34141584	3	59	theme	clinical	313:320	arg1	symptoms					322:329	nonspecific clinical symptoms	301:329	nonspecific clinical symptoms such as intellectual deficiency and developmental delay	301:385	MAN1B1-CDG is a CDG with nonspecific clinical symptoms such as intellectual deficiency and developmental delay.
34141584	4	60	theme	final	454:458	arg1	diagnosis					460:468	its final diagnosis	450:468	its final diagnosis	450:468	Although up to 40 affected individuals were described so far, its final diagnosis is not straightforward using common biochemical methods due to the trace-level accumulation of defective glycan structures.
34141584	1	61	theme	ever-growing	129:140	arg1	group					142:146	an ever-growing group	126:146	an ever-growing group of genetic diseases affecting the glycosylation of proteins	126:206	Congenital disorders of glycosylation (CDG) constitute an ever-growing group of genetic diseases affecting the glycosylation of proteins.
34141584	1	61	theme	ever-growing	129:140	arg1	diseases					159:166	genetic diseases	151:166	genetic diseases affecting the glycosylation of proteins	151:206	Congenital disorders of glycosylation (CDG) constitute an ever-growing group of genetic diseases affecting the glycosylation of proteins.
34141584	7	62	theme	potential	1339:1347	arg1	defects					1385:1391	potential glycoprotein-specific glycosylation defects	1339:1391	potential glycoprotein-specific glycosylation defects	1339:1391	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	6	63	theme	intellectual	872:883	arg1	disability					885:894	unexplained intellectual disability	860:894	unexplained intellectual disability	860:894	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	6	64	theme	endo-β-acetylglucosaminidase	1114:1141	arg1	N-glycans					1160:1168	endo-β-acetylglucosaminidase H-released serum N-glycans	1114:1168	endo-β-acetylglucosaminidase H-released serum N-glycans	1114:1168	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	6	65	theme	N-glycans	1160:1168	arg1	analysis					1102:1109	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis	1011:1109	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans	1011:1168	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	6	66	theme	MALDI-TOF	1073:1081	arg1	spectrometry					1089:1100	matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry	1011:1100	spectrometry	1089:1100	The occurrence of MAN1B1-CDG in patients showing unexplained intellectual disability and development delay, as well as a particular transferrin glycosylation profile, can be ascertained notably using matrix assisted laser desorption/ionization - time of flight (MALDI-TOF) mass spectrometry analysis of endo-β-acetylglucosaminidase H-released serum N-glycans.
34141584	5	67	attach	present	612:618	arg1	study					602:606	this study	597:606	this study	597:606	In this study, we present three unreported MAN1B1-CDG individuals and propose a decision tree to reach diagnosis using a panel of techniques ranging from exome sequencing to gel electrophoresis and mass spectrometry.
34141584	5	67	attach	present	612:618	arg2	we					609:610	we	609:610	we	609:610	In this study, we present three unreported MAN1B1-CDG individuals and propose a decision tree to reach diagnosis using a panel of techniques ranging from exome sequencing to gel electrophoresis and mass spectrometry.
34141584	2	68	theme	multisystem	253:263	arg1	disorders					265:273	severe multisystem disorders	246:273	severe multisystem disorders	246:273	CDG individuals usually present with severe multisystem disorders.
34141584	7	69	theme	pathogenic	1200:1209	arg1	hypersialorrhea					1258:1272	hypersialorrhea	1258:1272	hypersialorrhea	1258:1272	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
34141584	7	69	theme	pathogenic	1200:1209	arg1	variants					1211:1218	new pathogenic variants	1196:1218	new pathogenic variants	1196:1218	In addition to reporting new pathogenic variants and additional clinical signs such as hypersialorrhea, we highlight particular biochemical features of MAN1B1-CDG with potential glycoprotein-specific glycosylation defects.
33361843	9	0	theme	butadion	1690:1697	arg1	administration					1672:1685	the administration	1668:1685	the administration of butadion	1668:1697	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	12	1	theme	quercetin	2372:2380	arg1	gel					2382:2384	20 % sterile quercetin gel	2359:2384	20 % sterile quercetin gel	2359:2384	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	2	2	theme	interest	345:352	arg1	polyphenols					381:391	natural polyphenols	373:391	natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers	373:460	Of particular scientific interest in this aspect are natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers.
33361843	13	3	theme	substances	2826:2835	arg1	compositions					2791:2802	compositions	2791:2802	compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios	2791:2901	CONCLUSIONS The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.
33361843	13	4	dep	CONCLUSIONS	2640:2650	arg1	indicate					2673:2680	indicate	2673:2680	indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios	2673:2901	CONCLUSIONS The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.
33361843	12	5	with	treatment	2334:2342	arg1	gel					2382:2384	20 % sterile quercetin gel	2359:2384	20 % sterile quercetin gel	2359:2384	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	1	6	theme	personnel	256:264	arg1	health					237:242	the health	233:242	the health of military personnel and civilians	233:278	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	4	7	theme	laboratory	679:688	arg1	rats-male					696:704	130 laboratory white rats-male	675:704	130 laboratory white rats-male of Wistar line sexually mature	675:735	MATERIAL AND METHODS The experiments were performed on 130 laboratory white rats-male of Wistar line sexually mature weighting 180-240 g. Animals once received a total X-ray dose equivalent to 4.25 Gy.
33361843	5	8	theme	reparative	880:889	arg1	regeneration					891:902	reparative regeneration	880:902	reparative regeneration	880:902	The effects ofquercetin and patulaten to the processes of reparative regeneration under conditions of X-ray irradiation andagainst the background of butadione suppression were investigated.
33361843	2	9	from	interest	345:352	arg1	aspect					362:367	this aspect	357:367	this aspect	357:367	Of particular scientific interest in this aspect are natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers.
33361843	12	10	theme	regeneration	2541:2552	arg1	processes					2517:2525	the processes	2513:2525	the processes of reparative regeneration	2513:2552	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	9	11	theme	reparative	1732:1741	arg1	regeneration					1743:1754	reparative regeneration	1732:1754	reparative regeneration	1732:1754	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	12	12	with	administration	2289:2302	arg1	gel					2382:2384	20 % sterile quercetin gel	2359:2384	20 % sterile quercetin gel	2359:2384	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	11	13	from	processes	2153:2161	arg1	rats					2221:2224	intact and irradiated white rats	2193:2224	intact and irradiated white rats	2193:2224	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	3	14	theme	substances	582:591	arg1	compositions					548:559	compositions	548:559	compositions of plantpolyphenolic substances (PPS) and polysaccharides	548:617	OBJECTIVE Justification of the prospects of creating radioprotective agents based on compositions of plantpolyphenolic substances (PPS) and polysaccharides.
33361843	13	15	theme	regeneration	2759:2770	arg1	processes					2772:2780	regeneration processes	2759:2780	regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios	2759:2901	CONCLUSIONS The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.
33361843	1	16	theme	new	190:192	arg1	means					194:198	new means	190:198	new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation	190:317	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	11	17	theme	study	2066:2070	arg1	stage					2053:2057	the second stage	2042:2057	the second stage of the study	2042:2070	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	12	18	theme	wounds	2347:2352	arg1	treatment					2334:2342	the treatment	2330:2342	the treatment of wounds with 20 % sterile quercetin gel	2330:2384	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	12	18	theme	wounds	2347:2352	arg1	administration					2289:2302	The prophylactic administration	2272:2302	The prophylactic administration of quercetin granules	2272:2324	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	1	19	from	means	194:198	arg1	effects					289:295	the effects	285:295	the effects of ionizing radiation	285:317	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	9	20	from	increase	1703:1710	arg1	processes					1719:1727	the processes	1715:1727	the processes of reparative regeneration	1715:1754	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	9	20	from	increase	1703:1710	arg1	cells					1763:1767	the cells	1759:1767	the cells of the covering epitheliumof the esophagus	1759:1810	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	11	21	theme	substances	2100:2109	arg1	effect					2077:2082	the effect	2073:2082	the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats	2073:2224	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	12	22	theme	20	2359:2360	arg1	%					2362:2362	%	2362:2362	%	2362:2362	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	10	23	theme	animals	2007:2013	arg1	animals					2007:2013	animals	2007:2013	animals injected with butadion	2007:2036	At the same time, quercetin granulescaused the most expressive effect, which increased the statistically significant value of the mitotic index by 78.5 %in relation to the group of animals injected with butadion.
33361843	10	23	theme	animals	2007:2013	arg1	group					1998:2002	the group	1994:2002	the group of animals injected with butadion	1994:2036	At the same time, quercetin granulescaused the most expressive effect, which increased the statistically significant value of the mitotic index by 78.5 %in relation to the group of animals injected with butadion.
33361843	10	24	theme	same	1833:1836	arg1	time					1838:1841	the same time	1829:1841	the same time	1829:1841	At the same time, quercetin granulescaused the most expressive effect, which increased the statistically significant value of the mitotic index by 78.5 %in relation to the group of animals injected with butadion.
33361843	1	25	theme	nuclear	116:122	arg1	threats					134:140	nuclear radiation threats	116:140	nuclear radiation threats in the modern world	116:160	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	4	26	theme	g.	755:756	arg1	Animals					758:764	180-240 g. Animals	747:764	180-240 g. Animals once received a total X-ray dose equivalent to 4.25 Gy	747:819	MATERIAL AND METHODS The experiments were performed on 130 laboratory white rats-male of Wistar line sexually mature weighting 180-240 g. Animals once received a total X-ray dose equivalent to 4.25 Gy.
33361843	9	27	theme	pectin	1629:1634	arg1	rats					1644:1647	pectin towhite rats	1629:1647	pectin towhite rats	1629:1647	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	9	27	theme	pectin	1629:1634	arg1	minutes					1653:1659	30 minutes	1650:1659	30 minutes before the administration of butadion	1650:1697	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	1	28	theme	threats	134:140	arg1	level					107:111	The high level	98:111	The high level of nuclear radiation threats in the modern world	98:160	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	11	29	theme	compositions	2121:2132	arg1	effect					2077:2082	the effect	2073:2082	the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats	2073:2224	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	9	30	theme	epitheliumof	1785:1796	arg1	cells					1763:1767	the cells	1759:1767	the cells of the covering epitheliumof the esophagus	1759:1810	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	4	31	theme	Wistar	709:714	arg1	line					716:719	Wistar line	709:719	Wistar line sexually mature	709:735	MATERIAL AND METHODS The experiments were performed on 130 laboratory white rats-male of Wistar line sexually mature weighting 180-240 g. Animals once received a total X-ray dose equivalent to 4.25 Gy.
33361843	13	32	theme	radioprotective	2708:2722	arg1	drugs					2724:2728	radioprotective drugs	2708:2728	radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios	2708:2901	CONCLUSIONS The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.
33361843	8	33	from	background	1501:1510	arg1	animals					1556:1562	intact and irradiated animals	1534:1562	intact and irradiated animals	1534:1562	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	3	34	theme	prospects	494:502	arg1	Justification					473:485	OBJECTIVE Justification	463:485	OBJECTIVE Justification of the prospects of creating radioprotective agents	463:537	OBJECTIVE Justification of the prospects of creating radioprotective agents based on compositions of plantpolyphenolic substances (PPS) and polysaccharides.
33361843	11	35	theme	polyphenolic	2087:2098	arg1	substances					2100:2109	polyphenolic substances	2087:2109	polyphenolic substances	2087:2109	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	5	36	theme	irradiation	930:940	arg1	conditions					910:919	conditions	910:919	conditions of X-ray irradiation	910:940	The effects ofquercetin and patulaten to the processes of reparative regeneration under conditions of X-ray irradiation andagainst the background of butadione suppression were investigated.
33361843	11	37	theme	linear	2252:2257	arg1	wounds					2264:2269	linear skin wounds	2252:2269	linear skin wounds	2252:2269	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	12	38	theme	quercetin	2307:2315	arg1	granules					2317:2324	quercetin granules	2307:2324	quercetin granules	2307:2324	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	4	39	theme	X-ray	788:792	arg1	dose					794:797	a total X-ray dose	780:797	a total X-ray dose equivalent to 4.25 Gy	780:819	MATERIAL AND METHODS The experiments were performed on 130 laboratory white rats-male of Wistar line sexually mature weighting 180-240 g. Animals once received a total X-ray dose equivalent to 4.25 Gy.
33361843	9	40	theme	PPS	1597:1599	arg1	compositions					1611:1622	their compositions	1605:1622	their compositions with pectin towhite rats, 30 minutes before the administration of butadion	1605:1697	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	9	40	theme	PPS	1597:1599	arg1	administration					1579:1592	the oral administration	1570:1592	the oral administration of PPS	1570:1599	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	6	41	theme	study	1030:1034	arg1	groups					1036:1041	the study groups	1026:1041	the study groups	1026:1041	Indicators in the study groups were compared using the Student's t-test for independent samples; the differences were considered statistically significantat p < 0.05.
33361843	4	42	theme	equivalent	799:808	arg1	dose					794:797	a total X-ray dose	780:797	a total X-ray dose equivalent to 4.25 Gy	780:819	MATERIAL AND METHODS The experiments were performed on 130 laboratory white rats-male of Wistar line sexually mature weighting 180-240 g. Animals once received a total X-ray dose equivalent to 4.25 Gy.
33361843	0	43	theme	MEANS	42:46	arg1	CREATION					14:21	CREATION	14:21	CREATION OF RADIOPROTECTIVE MEANS	14:46	PROSPECTS FOR CREATION OF RADIOPROTECTIVE MEANS BASED ON NATURAL POLYPHENOLS AND POLYSACCHARIDES.
33361843	13	44	theme	quantitative	2883:2894	arg1	ratios					2896:2901	invarious qualitative and quantitative ratios	2857:2901	invarious qualitative and quantitative ratios	2857:2901	CONCLUSIONS The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.
33361843	2	45	theme	newdrugs	437:444	arg1	development					422:432	the development	418:432	the development of newdrugs, radiomodifiers	418:460	Of particular scientific interest in this aspect are natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers.
33361843	12	46	theme	inside	2618:2623	arg1	use					2614:2616	simultaneous use	2601:2616	simultaneous use inside and topically	2601:2637	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	2	47	theme	natural	373:379	arg1	polyphenols					381:391	natural polyphenols	373:391	natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers	373:460	Of particular scientific interest in this aspect are natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers.
33361843	8	48	from	animals	1556:1562	arg1	background					1501:1510	the background	1497:1510	the background of its suppression in intact and irradiated animals	1497:1562	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	12	49	contain	have	2483:2486	arg2	ability					2492:2498	the ability to stimulate the processes of reparative regeneration	2488:2552	the ability to stimulate the processes of reparative regeneration	2488:2552	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	12	49	contain	have	2483:2486	arg1	granules					2474:2481	quercetin granules	2464:2481	quercetin granules	2464:2481	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	5	50	theme	suppression	981:991	arg1	background					957:966	the background	953:966	the background of butadione suppression	953:991	The effects ofquercetin and patulaten to the processes of reparative regeneration under conditions of X-ray irradiation andagainst the background of butadione suppression were investigated.
33361843	11	51	theme	reparative	2166:2175	arg1	regeneration					2177:2188	reparative regeneration	2166:2188	reparative regeneration in intact and irradiated white rats	2166:2224	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	6	52	from	Indicators	1012:1021	arg1	groups					1036:1041	the study groups	1026:1041	the study groups	1026:1041	Indicators in the study groups were compared using the Student's t-test for independent samples; the differences were considered statistically significantat p < 0.05.
33361843	8	53	theme	andtheir	1407:1414	arg1	compositions					1416:1427	PPS andtheir compositions	1403:1427	PPS andtheir compositions with polysaccharides	1403:1448	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	7	54	theme	quercetin	1224:1232	arg1	properties					1210:1219	The various biological properties	1187:1219	The various biological properties of quercetin	1187:1232	RESULTS The various biological properties of quercetin, in particular, the ability to bind hydroxyl radicals, is thepotential for developing radioprotective agents based on it.
33361843	9	55	theme	towhite	1636:1642	arg1	rats					1644:1647	pectin towhite rats	1629:1647	pectin towhite rats	1629:1647	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	9	55	theme	towhite	1636:1642	arg1	minutes					1653:1659	30 minutes	1650:1659	30 minutes before the administration of butadion	1650:1697	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	6	56	theme	independent	1088:1098	arg1	samples					1100:1106	independent samples	1088:1106	independent samples	1088:1106	Indicators in the study groups were compared using the Student's t-test for independent samples; the differences were considered statistically significantat p < 0.05.
33361843	11	57	theme	white	2215:2219	arg1	rats					2221:2224	intact and irradiated white rats	2193:2224	intact and irradiated white rats	2193:2224	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	2	58	theme	promising	398:406	arg1	basis					408:412	a promising basis	396:412	a promising basis for the development of newdrugs, radiomodifiers	396:460	Of particular scientific interest in this aspect are natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers.
33361843	0	59	theme	RADIOPROTECTIVE	26:40	arg1	MEANS					42:46	RADIOPROTECTIVE MEANS	26:46	RADIOPROTECTIVE MEANS	26:46	PROSPECTS FOR CREATION OF RADIOPROTECTIVE MEANS BASED ON NATURAL POLYPHENOLS AND POLYSACCHARIDES.
33361843	0	60	theme	NATURAL	57:63	arg1	POLYPHENOLS					65:75	NATURAL POLYPHENOLS	57:75	NATURAL POLYPHENOLS	57:75	PROSPECTS FOR CREATION OF RADIOPROTECTIVE MEANS BASED ON NATURAL POLYPHENOLS AND POLYSACCHARIDES.
33361843	2	61	theme	scientific	334:343	arg1	interest					345:352	particular scientific interest	323:352	particular scientific interest in this aspect	323:367	Of particular scientific interest in this aspect are natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers.
33361843	7	62	theme	various	1191:1197	arg1	properties					1210:1219	The various biological properties	1187:1219	The various biological properties of quercetin	1187:1232	RESULTS The various biological properties of quercetin, in particular, the ability to bind hydroxyl radicals, is thepotential for developing radioprotective agents based on it.
33361843	1	63	theme	ionizing	300:307	arg1	radiation					309:317	ionizing radiation	300:317	ionizing radiation	300:317	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	10	64	theme	significant	1931:1941	arg1	value					1943:1947	the statistically significant value	1913:1947	the statistically significant value of the mitotic index	1913:1968	At the same time, quercetin granulescaused the most expressive effect, which increased the statistically significant value of the mitotic index by 78.5 %in relation to the group of animals injected with butadion.
33361843	1	65	from	level	107:111	arg1	world					156:160	the modern world	145:160	the modern world	145:160	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	1	66	theme	pharmacological	203:217	arg1	protection					219:228	pharmacological protection	203:228	pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation	203:317	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	8	67	theme	first	1363:1367	arg1	stage					1369:1373	the first stage	1359:1373	the first stage of the study	1359:1386	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	7	68	theme	radioprotective	1320:1334	arg1	agents					1336:1341	radioprotective agents	1320:1341	radioprotective agents based on it	1320:1353	RESULTS The various biological properties of quercetin, in particular, the ability to bind hydroxyl radicals, is thepotential for developing radioprotective agents based on it.
33361843	3	69	theme	radioprotective	516:530	arg1	agents					532:537	radioprotective agents	516:537	radioprotective agents	516:537	OBJECTIVE Justification of the prospects of creating radioprotective agents based on compositions of plantpolyphenolic substances (PPS) and polysaccharides.
33361843	6	70	theme	significantat	1155:1167	arg1	<					1171:1171	statistically significantat p < 0.05	1141:1176	statistically significantat p < 0.05	1141:1176	Indicators in the study groups were compared using the Student's t-test for independent samples; the differences were considered statistically significantat p < 0.05.
33361843	10	71	theme	mitotic	1956:1962	arg1	index					1964:1968	the mitotic index	1952:1968	the mitotic index	1952:1968	At the same time, quercetin granulescaused the most expressive effect, which increased the statistically significant value of the mitotic index by 78.5 %in relation to the group of animals injected with butadion.
33361843	13	72	theme	polyphenolic	2813:2824	arg1	substances					2826:2835	plant polyphenolic substances	2807:2835	plant polyphenolic substances	2807:2835	CONCLUSIONS The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.
33361843	1	73	theme	health	237:242	arg1	protection					219:228	pharmacological protection	203:228	pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation	203:317	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	12	74	theme	greatest	2576:2583	arg1	efficiency					2585:2594	the greatest efficiency	2572:2594	the greatest efficiency	2572:2594	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	12	75	theme	sterile	2364:2370	arg1	gel					2382:2384	20 % sterile quercetin gel	2359:2384	20 % sterile quercetin gel	2359:2384	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	11	76	from	rats	2221:2224	arg1	processes					2153:2161	the processes	2149:2161	the processes of reparative regeneration in intact and irradiated white rats	2149:2224	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	1	77	from	effects	289:295	arg1	means					194:198	new means	190:198	new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation	190:317	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	1	77	from	effects	289:295	arg1	protection					219:228	pharmacological protection	203:228	pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation	203:317	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	8	78	from	effect	1393:1398	arg1	regeneration					1464:1475	reparative regeneration	1453:1475	reparative regeneration	1453:1475	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	1	79	theme	military	247:254	arg1	personnel					256:264	military personnel	247:264	military personnel	247:264	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	5	80	dep	effects	826:832	arg1	andagainst					942:951	andagainst	942:951	andagainst the background of butadione suppression	942:991	The effects ofquercetin and patulaten to the processes of reparative regeneration under conditions of X-ray irradiation andagainst the background of butadione suppression were investigated.
33361843	7	81	from	thepotential	1292:1303	arg1	particular					1238:1247	particular	1238:1247	particular	1238:1247	RESULTS The various biological properties of quercetin, in particular, the ability to bind hydroxyl radicals, is thepotential for developing radioprotective agents based on it.
33361843	5	82	theme	X-ray	924:928	arg1	irradiation					930:940	X-ray irradiation	924:940	X-ray irradiation	924:940	The effects ofquercetin and patulaten to the processes of reparative regeneration under conditions of X-ray irradiation andagainst the background of butadione suppression were investigated.
33361843	12	83	theme	reparative	2530:2539	arg1	regeneration					2541:2552	reparative regeneration	2530:2552	reparative regeneration	2530:2552	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	11	84	from	regeneration	2177:2188	arg1	rats					2221:2224	intact and irradiated white rats	2193:2224	intact and irradiated white rats	2193:2224	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	11	85	theme	wounds	2264:2269	arg1	model					2243:2247	a model	2241:2247	a model of linear skin wounds	2241:2269	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	5	86	theme	regeneration	891:902	arg1	processes					867:875	the processes	863:875	the processes of reparative regeneration	863:902	The effects ofquercetin and patulaten to the processes of reparative regeneration under conditions of X-ray irradiation andagainst the background of butadione suppression were investigated.
33361843	2	87	from	aspect	362:367	arg1	polyphenols					381:391	natural polyphenols	373:391	natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers	373:460	Of particular scientific interest in this aspect are natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers.
33361843	4	88	theme	white	690:694	arg1	rats-male					696:704	130 laboratory white rats-male	675:704	130 laboratory white rats-male of Wistar line sexually mature	675:735	MATERIAL AND METHODS The experiments were performed on 130 laboratory white rats-male of Wistar line sexually mature weighting 180-240 g. Animals once received a total X-ray dose equivalent to 4.25 Gy.
33361843	9	89	with	compositions	1611:1622	arg1	rats					1644:1647	pectin towhite rats	1629:1647	pectin towhite rats	1629:1647	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	9	89	with	compositions	1611:1622	arg1	minutes					1653:1659	30 minutes	1650:1659	30 minutes before the administration of butadion	1650:1697	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	3	90	theme	plantpolyphenolic	564:580	arg1	substances					582:591	plantpolyphenolic substances	564:591	plantpolyphenolic substances (PPS)	564:597	OBJECTIVE Justification of the prospects of creating radioprotective agents based on compositions of plantpolyphenolic substances (PPS) and polysaccharides.
33361843	3	90	theme	plantpolyphenolic	564:580	arg1	PPS					594:596	PPS	594:596	PPS	594:596	OBJECTIVE Justification of the prospects of creating radioprotective agents based on compositions of plantpolyphenolic substances (PPS) and polysaccharides.
33361843	9	91	theme	regeneration	1743:1754	arg1	processes					1719:1727	the processes	1715:1727	the processes of reparative regeneration	1715:1754	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	7	92	from	particular	1238:1247	arg1	thepotential					1292:1303	thepotential	1292:1303	thepotential	1292:1303	RESULTS The various biological properties of quercetin, in particular, the ability to bind hydroxyl radicals, is thepotential for developing radioprotective agents based on it.
33361843	7	92	from	particular	1238:1247	arg1	ability					1254:1260	the ability to bind hydroxyl radicals,	1250:1287	ability	1254:1260	RESULTS The various biological properties of quercetin, in particular, the ability to bind hydroxyl radicals, is thepotential for developing radioprotective agents based on it.
33361843	8	93	with	compositions	1416:1427	arg1	polysaccharides					1434:1448	polysaccharides	1434:1448	polysaccharides	1434:1448	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	9	94	dep	epitheliumof	1785:1796	arg1	esophagus					1802:1810	the esophagus	1798:1810	the covering epitheliumof the esophagus	1772:1810	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	3	95	theme	polysaccharides	603:617	arg1	compositions					548:559	compositions	548:559	compositions of plantpolyphenolic substances (PPS) and polysaccharides	548:617	OBJECTIVE Justification of the prospects of creating radioprotective agents based on compositions of plantpolyphenolic substances (PPS) and polysaccharides.
33361843	9	96	theme	oral	1574:1577	arg1	administration					1579:1592	the oral administration	1570:1592	the oral administration of PPS	1570:1599	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	12	97	theme	%	2362:2362	arg1	gel					2382:2384	20 % sterile quercetin gel	2359:2384	20 % sterile quercetin gel	2359:2384	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	8	98	theme	suppression	1519:1529	arg1	background					1501:1510	the background	1497:1510	the background of its suppression in intact and irradiated animals	1497:1562	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	4	99	theme	mature	730:735	arg1	line					716:719	Wistar line	709:719	Wistar line sexually mature	709:735	MATERIAL AND METHODS The experiments were performed on 130 laboratory white rats-male of Wistar line sexually mature weighting 180-240 g. Animals once received a total X-ray dose equivalent to 4.25 Gy.
33361843	12	100	dep	healing	2416:2422	arg1	indicate					2450:2457	indicate	2450:2457	indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration	2450:2552	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	10	101	theme	expressive	1878:1887	arg1	effect					1889:1894	the most expressive effect	1869:1894	the most expressive effect	1869:1894	At the same time, quercetin granulescaused the most expressive effect, which increased the statistically significant value of the mitotic index by 78.5 %in relation to the group of animals injected with butadion.
33361843	1	102	theme	radiation	124:132	arg1	threats					134:140	nuclear radiation threats	116:140	nuclear radiation threats in the modern world	116:160	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	11	103	theme	second	2046:2051	arg1	stage					2053:2057	the second stage	2042:2057	the second stage of the study	2042:2070	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	9	104	theme	covering	1776:1783	arg1	epitheliumof					1785:1796	the covering epitheliumof the esophagus	1772:1810	the covering epitheliumof the esophagus	1772:1810	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	8	105	theme	intact	1534:1539	arg1	animals					1556:1562	intact and irradiated animals	1534:1562	intact and irradiated animals	1534:1562	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	8	106	theme	study	1382:1386	arg1	stage					1369:1373	the first stage	1359:1373	the first stage of the study	1359:1386	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	7	107	theme	hydroxyl	1270:1277	arg1	radicals					1279:1286	hydroxyl radicals	1270:1286	hydroxyl radicals	1270:1286	RESULTS The various biological properties of quercetin, in particular, the ability to bind hydroxyl radicals, is thepotential for developing radioprotective agents based on it.
33361843	4	108	dep	MATERIAL	620:627	arg1	experiments					645:655	The experiments	641:655	The experiments	641:655	MATERIAL AND METHODS The experiments were performed on 130 laboratory white rats-male of Wistar line sexually mature weighting 180-240 g. Animals once received a total X-ray dose equivalent to 4.25 Gy.
33361843	13	109	theme	invarious	2857:2865	arg1	ratios					2896:2901	invarious qualitative and quantitative ratios	2857:2901	invarious qualitative and quantitative ratios	2857:2901	CONCLUSIONS The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.
33361843	8	110	theme	irradiated	1545:1554	arg1	animals					1556:1562	intact and irradiated animals	1534:1562	intact and irradiated animals	1534:1562	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	1	111	theme	modern	149:154	arg1	world					156:160	the modern world	145:160	the modern world	145:160	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	12	112	theme	granules	2317:2324	arg1	treatment					2334:2342	the treatment	2330:2342	the treatment of wounds with 20 % sterile quercetin gel	2330:2384	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	12	112	theme	granules	2317:2324	arg1	administration					2289:2302	The prophylactic administration	2272:2302	The prophylactic administration of quercetin granules	2272:2324	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	9	113	with	administration	1579:1592	arg1	rats					1644:1647	pectin towhite rats	1629:1647	pectin towhite rats	1629:1647	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	9	113	with	administration	1579:1592	arg1	minutes					1653:1659	30 minutes	1650:1659	30 minutes before the administration of butadion	1650:1697	With the oral administration of PPS and their compositions with pectin towhite rats, 30 minutes before the administration of butadion, an increase in the processes of reparative regeneration in the cells of the covering epitheliumof the esophagus was observed.
33361843	4	114	theme	line	716:719	arg1	rats-male					696:704	130 laboratory white rats-male	675:704	130 laboratory white rats-male of Wistar line sexually mature	675:735	MATERIAL AND METHODS The experiments were performed on 130 laboratory white rats-male of Wistar line sexually mature weighting 180-240 g. Animals once received a total X-ray dose equivalent to 4.25 Gy.
33361843	1	115	from	world	156:160	arg1	level					107:111	The high level	98:111	The high level of nuclear radiation threats in the modern world	98:160	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	11	116	theme	skin	2259:2262	arg1	wounds					2264:2269	linear skin wounds	2252:2269	linear skin wounds	2252:2269	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	4	117	theme	total	782:786	arg1	dose					794:797	a total X-ray dose	780:797	a total X-ray dose equivalent to 4.25 Gy	780:819	MATERIAL AND METHODS The experiments were performed on 130 laboratory white rats-male of Wistar line sexually mature weighting 180-240 g. Animals once received a total X-ray dose equivalent to 4.25 Gy.
33361843	11	118	from	effect	2077:2082	arg1	processes					2153:2161	the processes	2149:2161	the processes of reparative regeneration in intact and irradiated white rats	2149:2224	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	8	119	from	suppression	1519:1529	arg1	animals					1556:1562	intact and irradiated animals	1534:1562	intact and irradiated animals	1534:1562	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	12	120	theme	prophylactic	2276:2287	arg1	administration					2289:2302	The prophylactic administration	2272:2302	The prophylactic administration of quercetin granules	2272:2324	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	13	121	dep	substances	2826:2835	arg1	ratios					2896:2901	invarious qualitative and quantitative ratios	2857:2901	invarious qualitative and quantitative ratios	2857:2901	CONCLUSIONS The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.
33361843	1	122	from	threats	134:140	arg1	world					156:160	the modern world	145:160	the modern world	145:160	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	5	123	theme	butadione	971:979	arg1	suppression					981:991	butadione suppression	971:991	butadione suppression	971:991	The effects ofquercetin and patulaten to the processes of reparative regeneration under conditions of X-ray irradiation andagainst the background of butadione suppression were investigated.
33361843	11	124	with	substances	2100:2109	arg1	pectin					2139:2144	pectin	2139:2144	pectin	2139:2144	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	11	125	theme	intact	2193:2198	arg1	rats					2221:2224	intact and irradiated white rats	2193:2224	intact and irradiated white rats	2193:2224	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	13	126	theme	research	2656:2663	arg1	results					2665:2671	The research results	2652:2671	The research results	2652:2671	CONCLUSIONS The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.
33361843	1	127	theme	civilians	270:278	arg1	health					237:242	the health	233:242	the health of military personnel and civilians	233:278	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	1	128	theme	high	102:105	arg1	level					107:111	The high level	98:111	The high level of nuclear radiation threats in the modern world	98:160	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	11	129	theme	regeneration	2177:2188	arg1	processes					2153:2161	the processes	2149:2161	the processes of reparative regeneration in intact and irradiated white rats	2149:2224	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	8	130	theme	PPS	1403:1405	arg1	compositions					1416:1427	PPS andtheir compositions	1403:1427	PPS andtheir compositions with polysaccharides	1403:1448	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	3	131	theme	OBJECTIVE	463:471	arg1	Justification					473:485	OBJECTIVE Justification	463:485	OBJECTIVE Justification of the prospects of creating radioprotective agents	463:537	OBJECTIVE Justification of the prospects of creating radioprotective agents based on compositions of plantpolyphenolic substances (PPS) and polysaccharides.
33361843	7	132	theme	biological	1199:1208	arg1	properties					1210:1219	The various biological properties	1187:1219	The various biological properties of quercetin	1187:1232	RESULTS The various biological properties of quercetin, in particular, the ability to bind hydroxyl radicals, is thepotential for developing radioprotective agents based on it.
33361843	8	133	theme	compositions	1416:1427	arg1	effect					1393:1398	the effect	1389:1398	the effect of PPS andtheir compositions with polysaccharides on reparative regeneration	1389:1475	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	11	134	theme	irradiated	2204:2213	arg1	rats					2221:2224	intact and irradiated white rats	2193:2224	intact and irradiated white rats	2193:2224	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	12	135	theme	quercetin	2464:2472	arg1	granules					2474:2481	quercetin granules	2464:2481	quercetin granules	2464:2481	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	2	136	theme	particular	323:332	arg1	interest					345:352	particular scientific interest	323:352	particular scientific interest in this aspect	323:367	Of particular scientific interest in this aspect are natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers.
33361843	13	137	theme	polysaccharides	2841:2855	arg1	compositions					2791:2802	compositions	2791:2802	compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios	2791:2901	CONCLUSIONS The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.
33361843	1	138	theme	radiation	309:317	arg1	effects					289:295	the effects	285:295	the effects of ionizing radiation	285:317	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	2	139	from	polyphenols	381:391	arg1	aspect					362:367	this aspect	357:367	this aspect	357:367	Of particular scientific interest in this aspect are natural polyphenols as a promising basis for the development of newdrugs, radiomodifiers.
33361843	8	140	theme	reparative	1453:1462	arg1	regeneration					1464:1475	reparative regeneration	1453:1475	reparative regeneration	1453:1475	At the first stage of the study, the effect of PPS andtheir compositions with polysaccharides on reparative regeneration was studied against the background of its suppression in intact and irradiated animals.
33361843	11	141	with	compositions	2121:2132	arg1	pectin					2139:2144	pectin	2139:2144	pectin	2139:2144	At the second stage of the study, the effect of polyphenolic substances and their compositions with pectin on the processes of reparative regeneration in intact and irradiated white rats was studied on a model of linear skin wounds.
33361843	13	142	theme	qualitative	2867:2877	arg1	ratios					2896:2901	invarious qualitative and quantitative ratios	2857:2901	invarious qualitative and quantitative ratios	2857:2901	CONCLUSIONS The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.
33361843	1	143	theme	protection	219:228	arg1	means					194:198	new means	190:198	new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation	190:317	The high level of nuclear radiation threats in the modern world determines the need to find new means of pharmacological protection of the health of military personnel and civilians from the effects of ionizing radiation.
33361843	6	144	theme	p	1169:1169	arg1	<					1171:1171	statistically significantat p < 0.05	1141:1176	statistically significantat p < 0.05	1141:1176	Indicators in the study groups were compared using the Student's t-test for independent samples; the differences were considered statistically significantat p < 0.05.
33361843	12	145	theme	simultaneous	2601:2612	arg1	use					2614:2616	simultaneous use	2601:2616	simultaneous use inside and topically	2601:2637	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	12	146	theme	process.Experimental	2424:2443	arg1	data					2445:2448	process.Experimental data	2424:2448	process.Experimental data	2424:2448	The prophylactic administration of quercetin granules and the treatment of wounds with 20 % sterile quercetin gel significantly accelerated the healing process.Experimental data indicate that quercetin granules have the ability to stimulate the processes of reparative regeneration, quercetin showed the greatest efficiency with simultaneous use inside and topically.
33361843	10	147	theme	index	1964:1968	arg1	value					1943:1947	the statistically significant value	1913:1947	the statistically significant value of the mitotic index	1913:1968	At the same time, quercetin granulescaused the most expressive effect, which increased the statistically significant value of the mitotic index by 78.5 %in relation to the group of animals injected with butadion.
33361843	13	148	theme	plant	2807:2811	arg1	substances					2826:2835	plant polyphenolic substances	2807:2835	plant polyphenolic substances	2807:2835	CONCLUSIONS The research results indicate the promise of developing radioprotective drugs that can stimulatereparative regeneration processes based on compositions of plant polyphenolic substances and polysaccharides invarious qualitative and quantitative ratios.
32470588	6	0	theme	isotherm	868:875	arg1	order					795:799	Pseudo second order	781:799	Pseudo second order	781:799	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	6	0	theme	isotherm	868:875	arg1	models					814:819	Langmuir models	805:819	Langmuir models	805:819	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	6	0	theme	isotherm	868:875	arg1	models					877:882	the most suitable kinetic and isotherm models	838:882	the most suitable kinetic and isotherm models	838:882	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	5	1	theme	main	687:690	arg1	formation					668:676	hydrogen bonding formation	651:676	hydrogen bonding formation	651:676	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	5	1	theme	main	687:690	arg1	interaction					635:645	electrostatic interaction	621:645	electrostatic interaction	621:645	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	5	1	theme	main	687:690	arg1	interactions					692:703	the main interactions	683:703	the main interactions	683:703	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	9	2	theme	Different	1068:1076	arg1	solvents					1078:1085	Different solvents	1068:1085	Different solvents	1068:1085	Different solvents were applied for the regeneration of dye adsorbed-agar/κ-carrageenan hydrogel and the most suitable solvent was determined as ethyl alcohol.
32470588	10	3	theme	agar/κ-carrageenan	1258:1275	arg1	hydrogel					1277:1284	agar/κ-carrageenan hydrogel	1258:1284	agar/κ-carrageenan hydrogel	1258:1284	The results demonstrated that agar/κ-carrageenan hydrogel is a promising adsorbent for the removal of cationic dyes from water.
32470588	10	3	theme	agar/κ-carrageenan	1258:1275	arg1	adsorbent					1301:1309	adsorbent	1301:1309	adsorbent	1301:1309	The results demonstrated that agar/κ-carrageenan hydrogel is a promising adsorbent for the removal of cationic dyes from water.
32470588	4	4	used	used	551:554	arg2	hydrogel					344:351	agar/κ-carrageenan composite hydrogel adsorbent	315:361	agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements	315:545	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	8	5	theme	Thermodynamic	979:991	arg1	parameters					993:1002	Thermodynamic parameters	979:1002	Thermodynamic parameters	979:1002	Thermodynamic parameters were calculated to understand the nature of adsorption process.
32470588	6	6	theme	suitable	847:854	arg1	order					795:799	Pseudo second order	781:799	Pseudo second order	781:799	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	6	6	theme	suitable	847:854	arg1	models					814:819	Langmuir models	805:819	Langmuir models	805:819	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	6	6	theme	suitable	847:854	arg1	models					877:882	the most suitable kinetic and isotherm models	838:882	the most suitable kinetic and isotherm models	838:882	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	4	7	theme	glycol	449:454	arg1	ether					465:469	tri (ethylene glycol) divinyl ether	435:469	tri (ethylene glycol) divinyl ether	435:469	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	5	8	theme	hydrogen	651:658	arg1	formation					668:676	hydrogen bonding formation	651:676	hydrogen bonding formation	651:676	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	5	8	theme	hydrogen	651:658	arg1	interaction					635:645	electrostatic interaction	621:645	electrostatic interaction	621:645	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	5	8	theme	hydrogen	651:658	arg1	interactions					692:703	the main interactions	683:703	the main interactions	683:703	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	4	9	theme	cross-linking	393:405	arg1	reaction					407:414	free radical cross-linking reaction	380:414	free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether	380:469	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	8	10	theme	process	1059:1065	arg1	nature					1038:1043	the nature	1034:1043	the nature of adsorption process	1034:1065	Thermodynamic parameters were calculated to understand the nature of adsorption process.
32470588	5	11	from	interactions	692:703	arg1	removal					723:729	the adsorptive removal	708:729	the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel	708:778	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	5	12	theme	bonding	660:666	arg1	formation					668:676	hydrogen bonding formation	651:676	hydrogen bonding formation	651:676	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	5	12	theme	bonding	660:666	arg1	interaction					635:645	electrostatic interaction	621:645	electrostatic interaction	621:645	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	5	12	theme	bonding	660:666	arg1	interactions					692:703	the main interactions	683:703	the main interactions	683:703	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	6	13	theme	Pseudo	781:786	arg1	order					795:799	Pseudo second order	781:799	Pseudo second order	781:799	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	6	13	theme	Pseudo	781:786	arg1	models					814:819	Langmuir models	805:819	Langmuir models	805:819	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	6	13	theme	Pseudo	781:786	arg1	models					877:882	the most suitable kinetic and isotherm models	838:882	the most suitable kinetic and isotherm models	838:882	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	2	14	from	removal	211:217	arg1	water					232:236	water	232:236	water	232:236	Adsorption technique is successfully applied for the removal of dyes from water.
32470588	4	15	theme	ether	465:469	arg1	presence					423:430	the presence	419:430	the presence of tri (ethylene glycol) divinyl ether	419:469	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	5	16	theme	FTIR	593:596	arg1	results					598:604	FTIR results	593:604	FTIR results	593:604	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	4	17	from	reaction	407:414	arg1	presence					423:430	the presence	419:430	the presence of tri (ethylene glycol) divinyl ether	419:469	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	7	18	theme	Maximum	899:905	arg1	capacity					922:929	Maximum dye adsorption capacity	899:929	Maximum dye adsorption capacity of 242.3 mg·g-1	899:945	Maximum dye adsorption capacity of 242.3 mg·g-1 was obtained at 35 °C and pH 7.
32470588	9	19	theme	ethyl	1213:1217	arg1	alcohol					1219:1225	ethyl alcohol	1213:1225	ethyl alcohol	1213:1225	Different solvents were applied for the regeneration of dye adsorbed-agar/κ-carrageenan hydrogel and the most suitable solvent was determined as ethyl alcohol.
32470588	9	19	theme	ethyl	1213:1217	arg1	solvent					1187:1193	the most suitable solvent	1169:1193	the most suitable solvent	1169:1193	Different solvents were applied for the regeneration of dye adsorbed-agar/κ-carrageenan hydrogel and the most suitable solvent was determined as ethyl alcohol.
32470588	5	20	theme	Blue	744:747	arg1	Methylene					734:742	Methylene Blue	734:747	Methylene Blue	734:747	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	2	21	from	water	232:236	arg1	dyes					222:225	dyes	222:225	dyes from water	222:236	Adsorption technique is successfully applied for the removal of dyes from water.
32470588	2	21	from	water	232:236	arg1	removal					211:217	the removal	207:217	the removal of dyes from water	207:236	Adsorption technique is successfully applied for the removal of dyes from water.
32470588	5	22	theme	Methylene	734:742	arg1	removal					723:729	the adsorptive removal	708:729	the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel	708:778	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	0	23	theme	composite	19:27	arg1	hydrogel					29:36	Agar/κ-carrageenan composite hydrogel	0:36	Agar/κ-carrageenan composite hydrogel	0:36	Agar/κ-carrageenan composite hydrogel adsorbent for the removal of Methylene Blue from water.
32470588	8	24	theme	adsorption	1048:1057	arg1	process					1059:1065	adsorption process	1048:1065	adsorption process	1048:1065	Thermodynamic parameters were calculated to understand the nature of adsorption process.
32470588	7	25	theme	242.3 mg·g-1	934:945	arg1	capacity					922:929	Maximum dye adsorption capacity	899:929	Maximum dye adsorption capacity of 242.3 mg·g-1	899:945	Maximum dye adsorption capacity of 242.3 mg·g-1 was obtained at 35 °C and pH 7.
32470588	0	26	theme	Agar/κ-carrageenan	0:17	arg1	hydrogel					29:36	Agar/κ-carrageenan composite hydrogel	0:36	Agar/κ-carrageenan composite hydrogel	0:36	Agar/κ-carrageenan composite hydrogel adsorbent for the removal of Methylene Blue from water.
32470588	5	27	theme	electrostatic	621:633	arg1	formation					668:676	hydrogen bonding formation	651:676	hydrogen bonding formation	651:676	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	5	27	theme	electrostatic	621:633	arg1	interactions					692:703	the main interactions	683:703	the main interactions	683:703	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	5	27	theme	electrostatic	621:633	arg1	interaction					635:645	electrostatic interaction	621:645	electrostatic interaction	621:645	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	4	28	theme	radical	385:391	arg1	reaction					407:414	free radical cross-linking reaction	380:414	free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether	380:469	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	1	29	theme	Water	94:98	arg1	problem					149:155	a significant global problem	128:155	a significant global problem	128:155	Water pollution caused by dyes is a significant global problem.
32470588	1	29	theme	Water	94:98	arg1	pollution					100:108	Water pollution	94:108	Water pollution caused by dyes	94:123	Water pollution caused by dyes is a significant global problem.
32470588	4	30	theme	TGA	530:532	arg1	measurements					534:545	FTIR, SEM and TGA measurements	516:545	FTIR, SEM and TGA measurements	516:545	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	4	31	theme	free	380:383	arg1	reaction					407:414	free radical cross-linking reaction	380:414	free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether	380:469	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	10	32	from	removal	1319:1325	arg1	water					1349:1353	water	1349:1353	water	1349:1353	The results demonstrated that agar/κ-carrageenan hydrogel is a promising adsorbent for the removal of cationic dyes from water.
32470588	4	33	dep	hydrogel	344:351	arg1	characterized					493:505	characterized	493:505	characterized by using FTIR, SEM and TGA measurements	493:545	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	4	33	dep	hydrogel	344:351	arg1	prepared					363:370	prepared	363:370	prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker	363:487	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	6	34	theme	second	788:793	arg1	order					795:799	Pseudo second order	781:799	Pseudo second order	781:799	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	6	34	theme	second	788:793	arg1	models					814:819	Langmuir models	805:819	Langmuir models	805:819	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	6	34	theme	second	788:793	arg1	models					877:882	the most suitable kinetic and isotherm models	838:882	the most suitable kinetic and isotherm models	838:882	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	0	35	from	water	87:91	arg1	removal					56:62	the removal	52:62	the removal of Methylene Blue from water	52:91	Agar/κ-carrageenan composite hydrogel adsorbent for the removal of Methylene Blue from water.
32470588	10	36	theme	dyes	1339:1342	arg1	removal					1319:1325	the removal	1315:1325	the removal of cationic dyes from water	1315:1353	The results demonstrated that agar/κ-carrageenan hydrogel is a promising adsorbent for the removal of cationic dyes from water.
32470588	9	37	theme	adsorbed-agar/κ-carrageenan	1128:1154	arg1	hydrogel					1156:1163	dye adsorbed-agar/κ-carrageenan hydrogel	1124:1163	dye adsorbed-agar/κ-carrageenan hydrogel	1124:1163	Different solvents were applied for the regeneration of dye adsorbed-agar/κ-carrageenan hydrogel and the most suitable solvent was determined as ethyl alcohol.
32470588	3	38	from	technique	247:255	arg1	use					262:264	the use	258:264	the use of effective adsorbents	258:288	In this technique, the use of effective adsorbents is very important.
32470588	3	38	from	technique	247:255	arg1	important					298:306	important	298:306	important	298:306	In this technique, the use of effective adsorbents is very important.
32470588	4	39	theme	ethylene	440:447	arg1	ether					465:469	tri (ethylene glycol) divinyl ether	435:469	tri (ethylene glycol) divinyl ether	435:469	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	9	40	theme	hydrogel	1156:1163	arg1	regeneration					1108:1119	the regeneration	1104:1119	the regeneration of dye adsorbed-agar/κ-carrageenan hydrogel	1104:1163	Different solvents were applied for the regeneration of dye adsorbed-agar/κ-carrageenan hydrogel and the most suitable solvent was determined as ethyl alcohol.
32470588	9	41	theme	suitable	1178:1185	arg1	alcohol					1219:1225	ethyl alcohol	1213:1225	ethyl alcohol	1213:1225	Different solvents were applied for the regeneration of dye adsorbed-agar/κ-carrageenan hydrogel and the most suitable solvent was determined as ethyl alcohol.
32470588	9	41	theme	suitable	1178:1185	arg1	solvent					1187:1193	the most suitable solvent	1169:1193	the most suitable solvent	1169:1193	Different solvents were applied for the regeneration of dye adsorbed-agar/κ-carrageenan hydrogel and the most suitable solvent was determined as ethyl alcohol.
32470588	5	42	theme	adsorptive	712:721	arg1	removal					723:729	the adsorptive removal	708:729	the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel	708:778	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	4	43	theme	divinyl	457:463	arg1	ether					465:469	tri (ethylene glycol) divinyl ether	435:469	tri (ethylene glycol) divinyl ether	435:469	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	4	44	theme	composite	334:342	arg1	hydrogel					344:351	agar/κ-carrageenan composite hydrogel adsorbent	315:361	agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements	315:545	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	4	45	theme	FTIR	516:519	arg1	measurements					534:545	FTIR, SEM and TGA measurements	516:545	FTIR, SEM and TGA measurements	516:545	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	2	46	theme	Adsorption	158:167	arg1	technique					169:177	Adsorption technique	158:177	Adsorption technique	158:177	Adsorption technique is successfully applied for the removal of dyes from water.
32470588	2	47	theme	dyes	222:225	arg1	removal					211:217	the removal	207:217	the removal of dyes from water	207:236	Adsorption technique is successfully applied for the removal of dyes from water.
32470588	4	48	theme	agar/κ-carrageenan	315:332	arg1	hydrogel					344:351	agar/κ-carrageenan composite hydrogel adsorbent	315:361	agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements	315:545	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	3	49	from	important	298:306	arg1	technique					247:255	this technique	242:255	this technique	242:255	In this technique, the use of effective adsorbents is very important.
32470588	4	50	theme	adsorbent	353:361	arg1	hydrogel					344:351	agar/κ-carrageenan composite hydrogel adsorbent	315:361	agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements	315:545	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	6	51	theme	kinetic	856:862	arg1	order					795:799	Pseudo second order	781:799	Pseudo second order	781:799	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	6	51	theme	kinetic	856:862	arg1	models					814:819	Langmuir models	805:819	Langmuir models	805:819	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	6	51	theme	kinetic	856:862	arg1	models					877:882	the most suitable kinetic and isotherm models	838:882	the most suitable kinetic and isotherm models	838:882	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	7	52	theme	adsorption	911:920	arg1	capacity					922:929	Maximum dye adsorption capacity	899:929	Maximum dye adsorption capacity of 242.3 mg·g-1	899:945	Maximum dye adsorption capacity of 242.3 mg·g-1 was obtained at 35 °C and pH 7.
32470588	4	53	theme	SEM	522:524	arg1	measurements					534:545	FTIR, SEM and TGA measurements	516:545	FTIR, SEM and TGA measurements	516:545	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	3	54	theme	effective	269:277	arg1	adsorbents					279:288	effective adsorbents	269:288	effective adsorbents	269:288	In this technique, the use of effective adsorbents is very important.
32470588	5	55	theme	agar/κ-carrageenan	752:769	arg1	hydrogel					771:778	agar/κ-carrageenan hydrogel	752:778	agar/κ-carrageenan hydrogel	752:778	FTIR results exhibited that electrostatic interaction and hydrogen bonding formation were the main interactions in the adsorptive removal of Methylene Blue by agar/κ-carrageenan hydrogel.
32470588	3	56	theme	adsorbents	279:288	arg1	use					262:264	the use	258:264	the use of effective adsorbents	258:288	In this technique, the use of effective adsorbents is very important.
32470588	3	56	theme	adsorbents	279:288	arg1	important					298:306	important	298:306	important	298:306	In this technique, the use of effective adsorbents is very important.
32470588	10	57	from	water	1349:1353	arg1	dyes					1339:1342	cationic dyes	1330:1342	cationic dyes from water	1330:1353	The results demonstrated that agar/κ-carrageenan hydrogel is a promising adsorbent for the removal of cationic dyes from water.
32470588	10	57	from	water	1349:1353	arg1	removal					1319:1325	the removal	1315:1325	the removal of cationic dyes from water	1315:1353	The results demonstrated that agar/κ-carrageenan hydrogel is a promising adsorbent for the removal of cationic dyes from water.
32470588	9	58	theme	dye	1124:1126	arg1	hydrogel					1156:1163	dye adsorbed-agar/κ-carrageenan hydrogel	1124:1163	dye adsorbed-agar/κ-carrageenan hydrogel	1124:1163	Different solvents were applied for the regeneration of dye adsorbed-agar/κ-carrageenan hydrogel and the most suitable solvent was determined as ethyl alcohol.
32470588	6	59	theme	Langmuir	805:812	arg1	order					795:799	Pseudo second order	781:799	Pseudo second order	781:799	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	6	59	theme	Langmuir	805:812	arg1	models					814:819	Langmuir models	805:819	Langmuir models	805:819	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	6	59	theme	Langmuir	805:812	arg1	models					877:882	the most suitable kinetic and isotherm models	838:882	the most suitable kinetic and isotherm models	838:882	Pseudo second order and Langmuir models were found to be the most suitable kinetic and isotherm models, respectively.
32470588	10	60	theme	cationic	1330:1337	arg1	dyes					1339:1342	cationic dyes	1330:1342	cationic dyes from water	1330:1353	The results demonstrated that agar/κ-carrageenan hydrogel is a promising adsorbent for the removal of cationic dyes from water.
32470588	0	61	theme	Blue	77:80	arg1	Methylene					67:75	Methylene Blue	67:80	Methylene Blue	67:80	Agar/κ-carrageenan composite hydrogel adsorbent for the removal of Methylene Blue from water.
32470588	4	62	theme	tri	435:437	arg1	ether					465:469	tri (ethylene glycol) divinyl ether	435:469	tri (ethylene glycol) divinyl ether	435:469	Here, agar/κ-carrageenan composite hydrogel adsorbent prepared through free radical cross-linking reaction in the presence of tri (ethylene glycol) divinyl ether as a cross-linker and characterized by using FTIR, SEM and TGA measurements was used to remove Methylene Blue from water.
32470588	1	63	theme	significant	130:140	arg1	pollution					100:108	Water pollution	94:108	Water pollution caused by dyes	94:123	Water pollution caused by dyes is a significant global problem.
32470588	1	63	theme	significant	130:140	arg1	problem					149:155	a significant global problem	128:155	a significant global problem	128:155	Water pollution caused by dyes is a significant global problem.
32470588	7	64	theme	dye	907:909	arg1	capacity					922:929	Maximum dye adsorption capacity	899:929	Maximum dye adsorption capacity of 242.3 mg·g-1	899:945	Maximum dye adsorption capacity of 242.3 mg·g-1 was obtained at 35 °C and pH 7.
32470588	0	65	theme	Methylene	67:75	arg1	removal					56:62	the removal	52:62	the removal of Methylene Blue from water	52:91	Agar/κ-carrageenan composite hydrogel adsorbent for the removal of Methylene Blue from water.
32470588	1	66	theme	global	142:147	arg1	pollution					100:108	Water pollution	94:108	Water pollution caused by dyes	94:123	Water pollution caused by dyes is a significant global problem.
32470588	1	66	theme	global	142:147	arg1	problem					149:155	a significant global problem	128:155	a significant global problem	128:155	Water pollution caused by dyes is a significant global problem.
33357837	6	0	theme	excellent	1083:1091	arg1	properties					1106:1115	excellent self-healing properties	1083:1115	excellent self-healing properties	1083:1115	Particularly, the bio-based GG/UiO-66 dispersion showed excellent self-healing properties, which enabled an effective pollutant separation ability and facilitated the recyclability/sustainability of the as-prepared membrane.
33357837	3	1	theme	bio-GG	645:650	arg1	nature					635:640	the nature	631:640	the nature of bio-GG and UiO-66	631:661	The water contact angle measurements indicated the hydrophilicity of the prepared membrane which can be attributed to the nature of bio-GG and UiO-66.
33357837	1	2	theme	polyvinylidene	275:288	arg1	matrix					299:304	polyvinylidene fluoride matrix	275:304	polyvinylidene fluoride matrix	275:304	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	1	3	theme	UiO-66	363:368	arg1	filler					370:375	UiO-66 filler	363:375	UiO-66 filler	363:375	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	6	4	theme	membrane	1242:1249	arg1	recyclability/sustainability					1194:1221	the recyclability/sustainability	1190:1221	the recyclability/sustainability of the as-prepared membrane	1190:1249	Particularly, the bio-based GG/UiO-66 dispersion showed excellent self-healing properties, which enabled an effective pollutant separation ability and facilitated the recyclability/sustainability of the as-prepared membrane.
33357837	6	5	theme	effective	1135:1143	arg1	ability					1166:1172	an effective pollutant separation ability	1132:1172	an effective pollutant separation ability	1132:1172	Particularly, the bio-based GG/UiO-66 dispersion showed excellent self-healing properties, which enabled an effective pollutant separation ability and facilitated the recyclability/sustainability of the as-prepared membrane.
33357837	1	6	theme	fluoride	290:297	arg1	matrix					299:304	polyvinylidene fluoride matrix	275:304	polyvinylidene fluoride matrix	275:304	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	0	7	theme	water	84:88	arg1	treatment					90:98	water treatment	84:98	water treatment	84:98	Processing Guar Gum into polyester fabric based promising mixed matrix membrane for water treatment.
33357837	4	8	contain	containing	733:742	arg1	waters					726:731	contaminated waters	713:731	contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up	713:842	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	4	8	contain	containing	733:742	arg2	N					754:754	N	754:754	N	754:754	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	4	8	contain	containing	733:742	arg2	N-cetyl-N					744:752	N-cetyl-N	744:752	N-cetyl-N	744:752	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	4	8	contain	containing	733:742	arg2	CR					806:807	CR	806:807	CR	806:807	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	4	8	contain	containing	733:742	arg2	bromide					776:782	N-trimethylammonium bromide	756:782	N-trimethylammonium bromide (CTAB)	756:789	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	4	8	contain	containing	733:742	arg2	dye					810:812	congo-red (CR) dye	795:812	congo-red (CR) dye	795:812	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	4	8	contain	containing	733:742	arg2	CTAB					785:788	CTAB	785:788	CTAB	785:788	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	5	9	theme	CR	956:957	arg1	concentration					959:971	CTAB and CR concentration	947:971	CTAB and CR concentration	947:971	The central composite design was also exploited to study the effect of operational parameters such as CTAB and CR concentration, pH solution, and pressure on the removal efficiency.
33357837	5	10	theme	operational	916:926	arg1	parameters					928:937	operational parameters	916:937	operational parameters such as CTAB and CR concentration, pH solution, and pressure	916:998	The central composite design was also exploited to study the effect of operational parameters such as CTAB and CR concentration, pH solution, and pressure on the removal efficiency.
33357837	5	10	theme	operational	916:926	arg1	concentration					959:971	CTAB and CR concentration	947:971	CTAB and CR concentration	947:971	The central composite design was also exploited to study the effect of operational parameters such as CTAB and CR concentration, pH solution, and pressure on the removal efficiency.
33357837	5	10	theme	operational	916:926	arg1	solution					977:984	pH solution	974:984	pH solution	974:984	The central composite design was also exploited to study the effect of operational parameters such as CTAB and CR concentration, pH solution, and pressure on the removal efficiency.
33357837	5	10	theme	operational	916:926	arg1	pressure					991:998	pressure	991:998	pressure	991:998	The central composite design was also exploited to study the effect of operational parameters such as CTAB and CR concentration, pH solution, and pressure on the removal efficiency.
33357837	5	11	theme	composite	857:865	arg1	design					867:872	The central composite design	845:872	The central composite design	845:872	The central composite design was also exploited to study the effect of operational parameters such as CTAB and CR concentration, pH solution, and pressure on the removal efficiency.
33357837	3	12	theme	angle	531:535	arg1	measurements					537:548	The water contact angle measurements	513:548	The water contact angle measurements	513:548	The water contact angle measurements indicated the hydrophilicity of the prepared membrane which can be attributed to the nature of bio-GG and UiO-66.
33357837	6	13	theme	bio-based	1045:1053	arg1	dispersion					1065:1074	the bio-based GG/UiO-66 dispersion	1041:1074	the bio-based GG/UiO-66 dispersion	1041:1074	Particularly, the bio-based GG/UiO-66 dispersion showed excellent self-healing properties, which enabled an effective pollutant separation ability and facilitated the recyclability/sustainability of the as-prepared membrane.
33357837	1	14	theme	Ag-nanoparticles	168:183	arg1	fabric					205:210	Ag-nanoparticles decorated polyester fabric	168:210	Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler	168:375	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	4	15	theme	cross-module	824:835	arg1	set-up					837:842	a cross-module set-up	822:842	a cross-module set-up	822:842	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	2	16	theme	stability	444:452	arg1	tests					454:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests	378:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests	378:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests were applied to characterize the prepared membranes.
33357837	1	17	theme	decorated	185:193	arg1	fabric					205:210	Ag-nanoparticles decorated polyester fabric	168:210	Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler	168:375	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	0	18	theme	Guar	11:14	arg1	Gum					16:18	Processing Guar Gum	0:18	Processing Guar Gum into polyester fabric	0:40	Processing Guar Gum into polyester fabric based promising mixed matrix membrane for water treatment.
33357837	3	19	theme	contact	523:529	arg1	measurements					537:548	The water contact angle measurements	513:548	The water contact angle measurements	513:548	The water contact angle measurements indicated the hydrophilicity of the prepared membrane which can be attributed to the nature of bio-GG and UiO-66.
33357837	5	20	theme	parameters	928:937	arg1	effect					906:911	the effect	902:911	the effect of operational parameters such as CTAB and CR concentration, pH solution, and pressure on the removal efficiency	902:1024	The central composite design was also exploited to study the effect of operational parameters such as CTAB and CR concentration, pH solution, and pressure on the removal efficiency.
33357837	1	21	theme	polyester	195:203	arg1	fabric					205:210	Ag-nanoparticles decorated polyester fabric	168:210	Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler	168:375	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	0	22	theme	Processing	0:9	arg1	Gum					16:18	Processing Guar Gum	0:18	Processing Guar Gum into polyester fabric	0:40	Processing Guar Gum into polyester fabric based promising mixed matrix membrane for water treatment.
33357837	5	23	theme	central	849:855	arg1	design					867:872	The central composite design	845:872	The central composite design	845:872	The central composite design was also exploited to study the effect of operational parameters such as CTAB and CR concentration, pH solution, and pressure on the removal efficiency.
33357837	3	24	theme	prepared	586:593	arg1	membrane					595:602	the prepared membrane	582:602	the prepared membrane which can be attributed to the nature of bio-GG and UiO-66	582:661	The water contact angle measurements indicated the hydrophilicity of the prepared membrane which can be attributed to the nature of bio-GG and UiO-66.
33357837	2	25	theme	XRD	386:388	arg1	tests					454:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests	378:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests	378:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests were applied to characterize the prepared membranes.
33357837	1	26	theme	guar	307:310	arg1	gum					312:314	guar gum	307:314	guar gum (GG) exo-polysaccharide hydrophilic agent	307:356	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	1	26	theme	guar	307:310	arg1	GG					317:318	GG	317:318	GG	317:318	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	5	27	from	effect	906:911	arg1	efficiency					1015:1024	the removal efficiency	1003:1024	the removal efficiency	1003:1024	The central composite design was also exploited to study the effect of operational parameters such as CTAB and CR concentration, pH solution, and pressure on the removal efficiency.
33357837	4	28	theme	N-trimethylammonium	756:774	arg1	CTAB					785:788	CTAB	785:788	CTAB	785:788	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	4	28	theme	N-trimethylammonium	756:774	arg1	bromide					776:782	N-trimethylammonium bromide	756:782	N-trimethylammonium bromide (CTAB)	756:789	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	6	29	theme	GG/UiO-66	1055:1063	arg1	dispersion					1065:1074	the bio-based GG/UiO-66 dispersion	1041:1074	the bio-based GG/UiO-66 dispersion	1041:1074	Particularly, the bio-based GG/UiO-66 dispersion showed excellent self-healing properties, which enabled an effective pollutant separation ability and facilitated the recyclability/sustainability of the as-prepared membrane.
33357837	2	30	theme	technique	418:426	arg1	tests					454:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests	378:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests	378:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests were applied to characterize the prepared membranes.
33357837	6	31	theme	separation	1155:1164	arg1	ability					1166:1172	an effective pollutant separation ability	1132:1172	an effective pollutant separation ability	1132:1172	Particularly, the bio-based GG/UiO-66 dispersion showed excellent self-healing properties, which enabled an effective pollutant separation ability and facilitated the recyclability/sustainability of the as-prepared membrane.
33357837	2	32	theme	mechanical	433:442	arg1	stability					444:452	mechanical stability	433:452	mechanical stability	433:452	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests were applied to characterize the prepared membranes.
33357837	5	33	theme	CTAB	947:950	arg1	concentration					959:971	CTAB and CR concentration	947:971	CTAB and CR concentration	947:971	The central composite design was also exploited to study the effect of operational parameters such as CTAB and CR concentration, pH solution, and pressure on the removal efficiency.
33357837	2	34	theme	angle	412:416	arg1	technique					418:426	water contact angle technique	398:426	water contact angle technique	398:426	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests were applied to characterize the prepared membranes.
33357837	3	35	theme	UiO-66	656:661	arg1	nature					635:640	the nature	631:640	the nature of bio-GG and UiO-66	631:661	The water contact angle measurements indicated the hydrophilicity of the prepared membrane which can be attributed to the nature of bio-GG and UiO-66.
33357837	4	36	theme	prepared	668:675	arg1	membrane					677:684	The prepared membrane	664:684	The prepared membrane	664:684	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	2	37	theme	contact	404:410	arg1	technique					418:426	water contact angle technique	398:426	water contact angle technique	398:426	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests were applied to characterize the prepared membranes.
33357837	0	38	theme	polyester	25:33	arg1	fabric					35:40	polyester fabric	25:40	polyester fabric	25:40	Processing Guar Gum into polyester fabric based promising mixed matrix membrane for water treatment.
33357837	2	39	theme	water	398:402	arg1	technique					418:426	water contact angle technique	398:426	water contact angle technique	398:426	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests were applied to characterize the prepared membranes.
33357837	0	40	theme	promising	48:56	arg1	membrane					71:78	promising mixed matrix membrane	48:78	promising mixed matrix membrane	48:78	Processing Guar Gum into polyester fabric based promising mixed matrix membrane for water treatment.
33357837	2	41	theme	prepared	493:500	arg1	membranes					502:510	the prepared membranes	489:510	the prepared membranes	489:510	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests were applied to characterize the prepared membranes.
33357837	3	42	theme	membrane	595:602	arg1	hydrophilicity					564:577	the hydrophilicity	560:577	the hydrophilicity of the prepared membrane which can be attributed to the nature of bio-GG and UiO-66	560:661	The water contact angle measurements indicated the hydrophilicity of the prepared membrane which can be attributed to the nature of bio-GG and UiO-66.
33357837	1	43	theme	reactive	103:110	arg1	support					142:148	A reactive and mechano-chemically stable support	101:148	A reactive and mechano-chemically stable support	101:148	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	1	44	theme	exo-polysaccharide	321:338	arg1	agent					352:356	exo-polysaccharide hydrophilic agent	321:356	guar gum (GG) exo-polysaccharide hydrophilic agent	307:356	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	5	45	theme	removal	1007:1013	arg1	efficiency					1015:1024	the removal efficiency	1003:1024	the removal efficiency	1003:1024	The central composite design was also exploited to study the effect of operational parameters such as CTAB and CR concentration, pH solution, and pressure on the removal efficiency.
33357837	4	46	theme	contaminated	713:724	arg1	waters					726:731	contaminated waters	713:731	contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up	713:842	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	1	47	theme	hydrophilic	340:350	arg1	agent					352:356	exo-polysaccharide hydrophilic agent	321:356	guar gum (GG) exo-polysaccharide hydrophilic agent	307:356	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	5	48	theme	pH	974:975	arg1	solution					977:984	pH solution	974:984	pH solution	974:984	The central composite design was also exploited to study the effect of operational parameters such as CTAB and CR concentration, pH solution, and pressure on the removal efficiency.
33357837	4	49	theme	congo-red	795:803	arg1	dye					810:812	congo-red (CR) dye	795:812	congo-red (CR) dye	795:812	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	4	49	theme	congo-red	795:803	arg1	CR					806:807	CR	806:807	CR	806:807	The prepared membrane was employed for purifying contaminated waters containing N-cetyl-N,N,N-trimethylammonium bromide (CTAB) and congo-red (CR) dye through a cross-module set-up.
33357837	6	50	theme	pollutant	1145:1153	arg1	ability					1166:1172	an effective pollutant separation ability	1132:1172	an effective pollutant separation ability	1132:1172	Particularly, the bio-based GG/UiO-66 dispersion showed excellent self-healing properties, which enabled an effective pollutant separation ability and facilitated the recyclability/sustainability of the as-prepared membrane.
33357837	6	51	theme	as-prepared	1230:1240	arg1	membrane					1242:1249	the as-prepared membrane	1226:1249	the as-prepared membrane	1226:1249	Particularly, the bio-based GG/UiO-66 dispersion showed excellent self-healing properties, which enabled an effective pollutant separation ability and facilitated the recyclability/sustainability of the as-prepared membrane.
33357837	1	52	theme	stable	135:140	arg1	support					142:148	A reactive and mechano-chemically stable support	101:148	A reactive and mechano-chemically stable support	101:148	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	0	53	theme	matrix	64:69	arg1	membrane					71:78	promising mixed matrix membrane	48:78	promising mixed matrix membrane	48:78	Processing Guar Gum into polyester fabric based promising mixed matrix membrane for water treatment.
33357837	6	54	theme	self-healing	1093:1104	arg1	properties					1106:1115	excellent self-healing properties	1083:1115	excellent self-healing properties	1083:1115	Particularly, the bio-based GG/UiO-66 dispersion showed excellent self-healing properties, which enabled an effective pollutant separation ability and facilitated the recyclability/sustainability of the as-prepared membrane.
33357837	3	55	theme	water	517:521	arg1	measurements					537:548	The water contact angle measurements	513:548	The water contact angle measurements	513:548	The water contact angle measurements indicated the hydrophilicity of the prepared membrane which can be attributed to the nature of bio-GG and UiO-66.
33357837	2	56	theme	FT-IR	391:395	arg1	tests					454:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests	378:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests	378:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests were applied to characterize the prepared membranes.
33357837	1	57	theme	casting	247:253	arg1	solution					255:262	a casting solution	245:262	a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler	245:375	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	0	58	theme	mixed	58:62	arg1	membrane					71:78	promising mixed matrix membrane	48:78	promising mixed matrix membrane	48:78	Processing Guar Gum into polyester fabric based promising mixed matrix membrane for water treatment.
33357837	1	59	dep	gum	312:314	arg1	agent					352:356	exo-polysaccharide hydrophilic agent	321:356	guar gum (GG) exo-polysaccharide hydrophilic agent	307:356	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	1	60	contain	containing	264:273	arg2	matrix					299:304	polyvinylidene fluoride matrix	275:304	polyvinylidene fluoride matrix	275:304	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	1	60	contain	containing	264:273	arg2	GG					317:318	GG	317:318	GG	317:318	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	1	60	contain	containing	264:273	arg1	solution					255:262	a casting solution	245:262	a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler	245:375	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	1	60	contain	containing	264:273	arg2	filler					370:375	UiO-66 filler	363:375	UiO-66 filler	363:375	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	1	60	contain	containing	264:273	arg2	gum					312:314	guar gum	307:314	guar gum (GG) exo-polysaccharide hydrophilic agent	307:356	A reactive and mechano-chemically stable support was prepared from Ag-nanoparticles decorated polyester fabric which was subsequently coated by a casting solution containing polyvinylidene fluoride matrix, guar gum (GG) exo-polysaccharide hydrophilic agent, and UiO-66 filler.
33357837	2	61	theme	FE-SEM	378:383	arg1	tests					454:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests	378:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests	378:458	FE-SEM, XRD, FT-IR, water contact angle technique, and mechanical stability tests were applied to characterize the prepared membranes.
34358601	0	0	theme	sugar	74:78	arg1	hydrogel					141:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.
34358601	11	1	theme	protection	1522:1531	arg1	field					1425:1429	the field	1421:1429	the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc	1421:1536	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	1	2	theme	sodium	169:174	arg1	C/SA/Fe					201:207	C/SA/Fe	201:207	C/SA/Fe	201:207	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel was fabricated by using epichlorohydrin as cross-linking agent as an effective adsorbent for dye.
34358601	1	2	theme	sodium	169:174	arg1	hydroxide					190:198	cellulose-based sodium alginate/iron hydroxide	153:198	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel	151:227	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel was fabricated by using epichlorohydrin as cross-linking agent as an effective adsorbent for dye.
34358601	6	3	theme	isotherm	892:899	arg1	results					870:876	the fitting results	858:876	the fitting results of adsorption isotherm	858:899	The modified hydrogel had better adsorption performance, and the maximum adsorption capacity of C/SA/Fe0.5 for MB was 105.93 mg/g according to the fitting results of adsorption isotherm.
34358601	1	4	theme	cross-linking	272:284	arg1	agent					286:290	cross-linking agent	272:290	cross-linking agent	272:290	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel was fabricated by using epichlorohydrin as cross-linking agent as an effective adsorbent for dye.
34358601	0	5	theme	reusable	65:72	arg1	hydrogel					141:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.
34358601	5	6	theme	FTIR	585:588	arg1	analysis					590:597	The FTIR analysis	581:597	The FTIR analysis	581:597	The FTIR analysis revealed that the Fe(OH)3 colloidal particles were successfully combined in the cellulose/sodium alginate hydrogel.
34358601	1	7	theme	alginate/iron	176:188	arg1	C/SA/Fe					201:207	C/SA/Fe	201:207	C/SA/Fe	201:207	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel was fabricated by using epichlorohydrin as cross-linking agent as an effective adsorbent for dye.
34358601	1	7	theme	alginate/iron	176:188	arg1	hydroxide					190:198	cellulose-based sodium alginate/iron hydroxide	153:198	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel	151:227	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel was fabricated by using epichlorohydrin as cross-linking agent as an effective adsorbent for dye.
34358601	0	8	theme	pulp	85:88	arg1	hydrogel					141:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.
34358601	5	9	theme	colloidal	625:633	arg1	particles					635:643	the Fe(OH)3 colloidal particles	613:643	the Fe(OH)3 colloidal particles	613:643	The FTIR analysis revealed that the Fe(OH)3 colloidal particles were successfully combined in the cellulose/sodium alginate hydrogel.
34358601	0	10	theme	beet	80:83	arg1	hydrogel					141:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.
34358601	5	11	theme	cellulose/sodium	679:694	arg1	hydrogel					705:712	the cellulose/sodium alginate hydrogel	675:712	the cellulose/sodium alginate hydrogel	675:712	The FTIR analysis revealed that the Fe(OH)3 colloidal particles were successfully combined in the cellulose/sodium alginate hydrogel.
34358601	0	12	theme	alginate/iron	107:119	arg1	hydrogel					141:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.
34358601	6	13	theme	adsorption	881:890	arg1	isotherm					892:899	adsorption isotherm	881:899	adsorption isotherm	881:899	The modified hydrogel had better adsorption performance, and the maximum adsorption capacity of C/SA/Fe0.5 for MB was 105.93 mg/g according to the fitting results of adsorption isotherm.
34358601	6	14	theme	adsorption	788:797	arg1	capacity					799:806	the maximum adsorption capacity	776:806	the maximum adsorption capacity of C/SA/Fe0.5 for MB	776:827	The modified hydrogel had better adsorption performance, and the maximum adsorption capacity of C/SA/Fe0.5 for MB was 105.93 mg/g according to the fitting results of adsorption isotherm.
34358601	1	15	theme	hydroxide	190:198	arg1	hydrogel					220:227	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel	151:227	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel	151:227	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel was fabricated by using epichlorohydrin as cross-linking agent as an effective adsorbent for dye.
34358601	0	16	theme	cellulose/sodium	90:105	arg1	hydrogel					141:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.
34358601	5	17	theme	Fe	617:618	arg1	particles					635:643	the Fe(OH)3 colloidal particles	613:643	the Fe(OH)3 colloidal particles	613:643	The FTIR analysis revealed that the Fe(OH)3 colloidal particles were successfully combined in the cellulose/sodium alginate hydrogel.
34358601	6	18	theme	maximum	780:786	arg1	capacity					799:806	the maximum adsorption capacity	776:806	the maximum adsorption capacity of C/SA/Fe0.5 for MB	776:827	The modified hydrogel had better adsorption performance, and the maximum adsorption capacity of C/SA/Fe0.5 for MB was 105.93 mg/g according to the fitting results of adsorption isotherm.
34358601	0	19	theme	biosorption	10:20	arg1	mechanism					22:30	Selective biosorption mechanism	0:30	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.	0:149	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.
34358601	11	20	theme	C/SA/Fe	1377:1383	arg1	hydrogel					1385:1392	the C/SA/Fe hydrogel	1373:1392	the C/SA/Fe hydrogel	1373:1392	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	11	20	theme	C/SA/Fe	1377:1383	arg1	material					1409:1416	a potential material	1397:1416	a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc	1397:1536	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	7	21	theme	ion	1075:1077	arg1	exchange					1079:1086	ion exchange	1075:1086	ion exchange	1075:1086	The kinetic study showed that the adsorption of MB onto C/SA/Fe was more consistent with the pseudo-second-order model, and was dominated by chemisorption mechanism such as ion exchange or electron sharing.
34358601	9	22	theme	MB	1204:1205	arg1	exothermic					1233:1242	exothermic	1233:1242	exothermic	1233:1242	Thermodynamics analysis showed that the MB adsorption by C/SA/Fe was exothermic, spontaneous, favorable and feasible.
34358601	9	22	theme	MB	1204:1205	arg1	adsorption					1207:1216	the MB adsorption	1200:1216	the MB adsorption by C/SA/Fe	1200:1227	Thermodynamics analysis showed that the MB adsorption by C/SA/Fe was exothermic, spontaneous, favorable and feasible.
34358601	11	23	theme	bio-based	1484:1492	arg1	cellulose					1494:1502	other bio-based cellulose	1478:1502	other bio-based cellulose	1478:1502	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	3	24	theme	adsorption	429:438	arg1	performance					440:450	The adsorption performance	425:450	The adsorption performance for the removal of methylene blue (MB)	425:489	The adsorption performance for the removal of methylene blue (MB) was investigated.
34358601	0	25	theme	Selective	0:8	arg1	mechanism					22:30	Selective biosorption mechanism	0:30	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.	0:149	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.
34358601	4	26	theme	cationic	550:557	arg1	dye					559:561	cationic dye	550:561	cationic dye	550:561	In addition, the selective adsorption of cationic dye was also studied.
34358601	5	27	theme	OH	620:621	arg1	particles					635:643	the Fe(OH)3 colloidal particles	613:643	the Fe(OH)3 colloidal particles	613:643	The FTIR analysis revealed that the Fe(OH)3 colloidal particles were successfully combined in the cellulose/sodium alginate hydrogel.
34358601	2	28	theme	physicochemical	331:345	arg1	structure					347:355	The physicochemical structure	327:355	The physicochemical structure of the C/SA/Fe hydrogel	327:379	The physicochemical structure of the C/SA/Fe hydrogel was characterized by SEM, FTIR, XRD and TG.
34358601	11	29	theme	agricultural	1450:1461	arg1	by-products					1463:1473	agricultural by-products	1450:1473	agricultural by-products	1450:1473	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	6	30	contain	had	737:739	arg2	performance					759:769	better adsorption performance	741:769	better adsorption performance	741:769	The modified hydrogel had better adsorption performance, and the maximum adsorption capacity of C/SA/Fe0.5 for MB was 105.93 mg/g according to the fitting results of adsorption isotherm.
34358601	6	30	contain	had	737:739	arg1	hydrogel					728:735	The modified hydrogel	715:735	The modified hydrogel	715:735	The modified hydrogel had better adsorption performance, and the maximum adsorption capacity of C/SA/Fe0.5 for MB was 105.93 mg/g according to the fitting results of adsorption isotherm.
34358601	0	31	theme	composite	131:139	arg1	hydrogel					141:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.
34358601	7	32	theme	MB	950:951	arg1	consistent					975:984	consistent	975:984	consistent	975:984	The kinetic study showed that the adsorption of MB onto C/SA/Fe was more consistent with the pseudo-second-order model, and was dominated by chemisorption mechanism such as ion exchange or electron sharing.
34358601	7	32	theme	MB	950:951	arg1	adsorption					936:945	the adsorption	932:945	the adsorption of MB onto C/SA/Fe	932:964	The kinetic study showed that the adsorption of MB onto C/SA/Fe was more consistent with the pseudo-second-order model, and was dominated by chemisorption mechanism such as ion exchange or electron sharing.
34358601	6	33	theme	C/SA/Fe0.5	811:820	arg1	capacity					799:806	the maximum adsorption capacity	776:806	the maximum adsorption capacity of C/SA/Fe0.5 for MB	776:827	The modified hydrogel had better adsorption performance, and the maximum adsorption capacity of C/SA/Fe0.5 for MB was 105.93 mg/g according to the fitting results of adsorption isotherm.
34358601	1	34	theme	composite	210:218	arg1	hydrogel					220:227	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel	151:227	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel	151:227	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel was fabricated by using epichlorohydrin as cross-linking agent as an effective adsorbent for dye.
34358601	6	35	theme	modified	719:726	arg1	hydrogel					728:735	The modified hydrogel	715:735	The modified hydrogel	715:735	The modified hydrogel had better adsorption performance, and the maximum adsorption capacity of C/SA/Fe0.5 for MB was 105.93 mg/g according to the fitting results of adsorption isotherm.
34358601	7	36	theme	chemisorption	1043:1055	arg1	mechanism					1057:1065	chemisorption mechanism	1043:1065	chemisorption mechanism such as ion exchange or electron sharing	1043:1106	The kinetic study showed that the adsorption of MB onto C/SA/Fe was more consistent with the pseudo-second-order model, and was dominated by chemisorption mechanism such as ion exchange or electron sharing.
34358601	0	37	theme	hydroxide	121:129	arg1	hydrogel					141:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.
34358601	6	38	theme	fitting	862:868	arg1	results					870:876	the fitting results	858:876	the fitting results of adsorption isotherm	858:899	The modified hydrogel had better adsorption performance, and the maximum adsorption capacity of C/SA/Fe0.5 for MB was 105.93 mg/g according to the fitting results of adsorption isotherm.
34358601	11	39	theme	recovery	1438:1445	arg1	field					1425:1429	the field	1421:1429	the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc	1421:1536	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	3	40	theme	blue	481:484	arg1	methylene					471:479	methylene blue	471:484	methylene blue (MB)	471:489	The adsorption performance for the removal of methylene blue (MB) was investigated.
34358601	3	40	theme	blue	481:484	arg1	MB					487:488	MB	487:488	MB	487:488	The adsorption performance for the removal of methylene blue (MB) was investigated.
34358601	0	41	theme	blue	45:48	arg1	methylene					35:43	methylene blue	35:48	methylene blue	35:48	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.
34358601	4	42	theme	dye	559:561	arg1	adsorption					536:545	the selective adsorption	522:545	the selective adsorption of cationic dye	522:561	In addition, the selective adsorption of cationic dye was also studied.
34358601	5	43	theme	alginate	696:703	arg1	hydrogel					705:712	the cellulose/sodium alginate hydrogel	675:712	the cellulose/sodium alginate hydrogel	675:712	The FTIR analysis revealed that the Fe(OH)3 colloidal particles were successfully combined in the cellulose/sodium alginate hydrogel.
34358601	10	44	theme	adsorption-desorption	1293:1313	arg1	cycles					1315:1320	five adsorption-desorption cycles	1288:1320	five adsorption-desorption cycles	1288:1320	After five adsorption-desorption cycles, the adsorption capacity was almost unchanged.
34358601	0	45	theme	methylene	35:43	arg1	mechanism					22:30	Selective biosorption mechanism	0:30	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.	0:149	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.
34358601	9	46	theme	Thermodynamics	1164:1177	arg1	analysis					1179:1186	Thermodynamics analysis	1164:1186	Thermodynamics analysis	1164:1186	Thermodynamics analysis showed that the MB adsorption by C/SA/Fe was exothermic, spontaneous, favorable and feasible.
34358601	11	47	theme	potential	1399:1407	arg1	hydrogel					1385:1392	the C/SA/Fe hydrogel	1373:1392	the C/SA/Fe hydrogel	1373:1392	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	11	47	theme	potential	1399:1407	arg1	material					1409:1416	a potential material	1397:1416	a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc	1397:1536	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	8	48	theme	Langmuir	1148:1155	arg1	model					1157:1161	the Langmuir model	1144:1161	the Langmuir model	1144:1161	The adsorption data fits well with the Langmuir model.
34358601	2	49	theme	hydrogel	372:379	arg1	structure					347:355	The physicochemical structure	327:355	The physicochemical structure of the C/SA/Fe hydrogel	327:379	The physicochemical structure of the C/SA/Fe hydrogel was characterized by SEM, FTIR, XRD and TG.
34358601	6	50	theme	better	741:746	arg1	performance					759:769	better adsorption performance	741:769	better adsorption performance	741:769	The modified hydrogel had better adsorption performance, and the maximum adsorption capacity of C/SA/Fe0.5 for MB was 105.93 mg/g according to the fitting results of adsorption isotherm.
34358601	2	51	theme	C/SA/Fe	364:370	arg1	hydrogel					372:379	the C/SA/Fe hydrogel	360:379	the C/SA/Fe hydrogel	360:379	The physicochemical structure of the C/SA/Fe hydrogel was characterized by SEM, FTIR, XRD and TG.
34358601	7	52	theme	kinetic	906:912	arg1	study					914:918	The kinetic study	902:918	The kinetic study	902:918	The kinetic study showed that the adsorption of MB onto C/SA/Fe was more consistent with the pseudo-second-order model, and was dominated by chemisorption mechanism such as ion exchange or electron sharing.
34358601	4	53	theme	selective	526:534	arg1	adsorption					536:545	the selective adsorption	522:545	the selective adsorption of cationic dye	522:561	In addition, the selective adsorption of cationic dye was also studied.
34358601	8	54	theme	adsorption	1113:1122	arg1	data					1124:1127	The adsorption data	1109:1127	The adsorption data	1109:1127	The adsorption data fits well with the Langmuir model.
34358601	7	55	theme	pseudo-second-order	995:1013	arg1	model					1015:1019	the pseudo-second-order model	991:1019	the pseudo-second-order model	991:1019	The kinetic study showed that the adsorption of MB onto C/SA/Fe was more consistent with the pseudo-second-order model, and was dominated by chemisorption mechanism such as ion exchange or electron sharing.
34358601	11	56	from	material	1409:1416	arg1	field					1425:1429	the field	1421:1429	the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc	1421:1536	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	11	57	theme	cellulose	1494:1502	arg1	etc					1534:1536	etc	1534:1536	etc	1534:1536	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	11	57	theme	cellulose	1494:1502	arg1	recovery					1438:1445	the recovery	1434:1445	the recovery of agricultural by-products or other bio-based cellulose	1434:1502	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	11	57	theme	cellulose	1494:1502	arg1	protection					1522:1531	environmental protection	1508:1531	environmental protection	1508:1531	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	10	58	theme	adsorption	1327:1336	arg1	capacity					1338:1345	the adsorption capacity	1323:1345	the adsorption capacity	1323:1345	After five adsorption-desorption cycles, the adsorption capacity was almost unchanged.
34358601	10	58	theme	adsorption	1327:1336	arg1	unchanged					1358:1366	unchanged	1358:1366	unchanged	1358:1366	After five adsorption-desorption cycles, the adsorption capacity was almost unchanged.
34358601	11	59	theme	by-products	1463:1473	arg1	etc					1534:1536	etc	1534:1536	etc	1534:1536	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	11	59	theme	by-products	1463:1473	arg1	recovery					1438:1445	the recovery	1434:1445	the recovery of agricultural by-products or other bio-based cellulose	1434:1502	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	11	59	theme	by-products	1463:1473	arg1	protection					1522:1531	environmental protection	1508:1531	environmental protection	1508:1531	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	11	60	theme	environmental	1508:1520	arg1	protection					1522:1531	environmental protection	1508:1531	environmental protection	1508:1531	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	3	61	theme	methylene	471:479	arg1	removal					460:466	the removal	456:466	the removal of methylene blue (MB)	456:489	The adsorption performance for the removal of methylene blue (MB) was investigated.
34358601	11	62	theme	other	1478:1482	arg1	cellulose					1494:1502	other bio-based cellulose	1478:1502	other bio-based cellulose	1478:1502	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
34358601	7	63	with	consistent	975:984	arg1	model					1015:1019	the pseudo-second-order model	991:1019	the pseudo-second-order model	991:1019	The kinetic study showed that the adsorption of MB onto C/SA/Fe was more consistent with the pseudo-second-order model, and was dominated by chemisorption mechanism such as ion exchange or electron sharing.
34358601	0	64	theme	novel	55:59	arg1	hydrogel					141:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel	53:148	Selective biosorption mechanism of methylene blue by a novel and reusable sugar beet pulp cellulose/sodium alginate/iron hydroxide composite hydrogel.
34358601	1	65	theme	cellulose-based	153:167	arg1	C/SA/Fe					201:207	C/SA/Fe	201:207	C/SA/Fe	201:207	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel was fabricated by using epichlorohydrin as cross-linking agent as an effective adsorbent for dye.
34358601	1	65	theme	cellulose-based	153:167	arg1	hydroxide					190:198	cellulose-based sodium alginate/iron hydroxide	153:198	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel	151:227	A cellulose-based sodium alginate/iron hydroxide (C/SA/Fe) composite hydrogel was fabricated by using epichlorohydrin as cross-linking agent as an effective adsorbent for dye.
34358601	6	66	dep	better	741:746	arg1	adsorption					748:757	adsorption	748:757	adsorption	748:757	The modified hydrogel had better adsorption performance, and the maximum adsorption capacity of C/SA/Fe0.5 for MB was 105.93 mg/g according to the fitting results of adsorption isotherm.
34358601	11	67	theme	etc	1534:1536	arg1	field					1425:1429	the field	1421:1429	the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc	1421:1536	So, the C/SA/Fe hydrogel is a potential material in the field of the recovery of agricultural by-products or other bio-based cellulose, or environmental protection, etc.
33892035	7	0	theme	increased	1231:1239	arg1	activity					1254:1261	the increased antibacerial activity	1227:1261	the increased antibacerial activity	1227:1261	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	7	0	theme	increased	1231:1239	arg1	mechanisms					1053:1062	The mechanisms	1049:1062	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs	1049:1136	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	2	1	theme	AgNPs	366:370	arg1	content					372:378	lower AgNPs content	360:378	lower AgNPs content than the commercial AgNPs	360:404	iturin-AgNPs was previously found to have much higher antibacterial activity at lower AgNPs content than the commercial AgNPs.
33892035	6	2	theme	loaded	1027:1032	arg1	AgNPs					1034:1038	the commercial wound dressing loaded AgNPs	997:1038	the commercial wound dressing loaded AgNPs	997:1038	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	7	3	theme	healing	1091:1097	arg1	promotion					1072:1080	the promotion	1068:1080	the promotion of wound healing by the CS dressing-loaded iturin-AgNPs	1068:1136	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	6	4	theme	infection	928:936	arg1	inhibition					904:913	more effective inhibition	889:913	more effective inhibition of bacterial infection	889:936	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	6	4	theme	infection	928:936	arg1	promotion					942:950	promotion	942:950	promotion of wound healing processing and quality	942:990	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	2	5	theme	lower	360:364	arg1	content					372:378	lower AgNPs content	360:378	lower AgNPs content than the commercial AgNPs	360:404	iturin-AgNPs was previously found to have much higher antibacterial activity at lower AgNPs content than the commercial AgNPs.
33892035	6	6	theme	dressing	1018:1025	arg1	AgNPs					1034:1038	the commercial wound dressing loaded AgNPs	997:1038	the commercial wound dressing loaded AgNPs	997:1038	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	6	7	theme	bacterial	918:926	arg1	infection					928:936	bacterial infection	918:936	bacterial infection	918:936	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	1	8	theme	effective	254:262	arg1	concentrations					264:277	effective concentrations	254:277	effective concentrations	254:277	Silver nanoparticles (AgNPs) are widely used in wound dressing, but are limited in the application due to its high toxicity at effective concentrations.
33892035	4	9	theme	high	690:693	arg1	results					649:655	results	649:655	results	649:655	As results, the synthesized CS dressing had high porosity and water absorption.
33892035	4	9	theme	high	690:693	arg1	porosity					695:702	high porosity	690:702	high porosity	690:702	As results, the synthesized CS dressing had high porosity and water absorption.
33892035	4	9	theme	high	690:693	arg1	absorption					714:723	water absorption	708:723	water absorption	708:723	As results, the synthesized CS dressing had high porosity and water absorption.
33892035	3	10	theme	chitosan	480:487	arg1	iturin-AgNPs					527:538	a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs	478:538	a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs	478:538	To verify its potential application in the promotion of wound healing, a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs was developed and evaluated for their antibacterial activity in vitro and used for wound healing in vivo.
33892035	7	11	theme	CS	1106:1107	arg1	iturin-AgNPs					1125:1136	the CS dressing-loaded iturin-AgNPs	1102:1136	the CS dressing-loaded iturin-AgNPs	1102:1136	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	1	12	used	used	167:170	arg2	nanoparticles					134:146	Silver nanoparticles	127:146	Silver nanoparticles (AgNPs)	127:154	Silver nanoparticles (AgNPs) are widely used in wound dressing, but are limited in the application due to its high toxicity at effective concentrations.
33892035	1	12	used	used	167:170	arg2	AgNPs					149:153	AgNPs	149:153	AgNPs	149:153	Silver nanoparticles (AgNPs) are widely used in wound dressing, but are limited in the application due to its high toxicity at effective concentrations.
33892035	4	13	theme	synthesized	662:672	arg1	dressing					677:684	the synthesized CS dressing	658:684	the synthesized CS dressing	658:684	As results, the synthesized CS dressing had high porosity and water absorption.
33892035	9	14	theme	great	1439:1443	arg1	potential					1445:1453	great potential	1439:1453	great potential	1439:1453	The study developed an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application.
33892035	6	15	theme	commercial	1001:1010	arg1	AgNPs					1034:1038	the commercial wound dressing loaded AgNPs	997:1038	the commercial wound dressing loaded AgNPs	997:1038	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	6	16	theme	effective	894:902	arg1	inhibition					904:913	more effective inhibition	889:913	more effective inhibition of bacterial infection	889:936	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	7	17	theme	dressing-loaded	1109:1123	arg1	iturin-AgNPs					1125:1136	the CS dressing-loaded iturin-AgNPs	1102:1136	the CS dressing-loaded iturin-AgNPs	1102:1136	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	6	18	theme	CS	850:851	arg1	iturin-AgNPs					869:880	The CS dressing-loaded iturin-AgNPs	846:880	The CS dressing-loaded iturin-AgNPs	846:880	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	6	19	theme	wound	955:959	arg1	healing					961:967	wound healing	955:967	wound healing processing	955:978	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	7	20	theme	formation	1205:1213	arg1	activity					1254:1261	the increased antibacerial activity	1227:1261	the increased antibacerial activity	1227:1261	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	7	20	theme	formation	1205:1213	arg1	enhancement					1156:1166	the enhancement	1152:1166	the enhancement of re-epithelialization and collagen formation	1152:1213	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	7	20	theme	formation	1205:1213	arg1	mechanisms					1053:1062	The mechanisms	1049:1062	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs	1049:1136	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	3	21	theme	dressing-loaded	511:525	arg1	iturin-AgNPs					527:538	a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs	478:538	a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs	478:538	To verify its potential application in the promotion of wound healing, a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs was developed and evaluated for their antibacterial activity in vitro and used for wound healing in vivo.
33892035	7	22	theme	antibacerial	1241:1252	arg1	activity					1254:1261	the increased antibacerial activity	1227:1261	the increased antibacerial activity	1227:1261	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	7	22	theme	antibacerial	1241:1252	arg1	mechanisms					1053:1062	The mechanisms	1049:1062	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs	1049:1136	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	2	23	theme	commercial	389:398	arg1	AgNPs					400:404	the commercial AgNPs	385:404	the commercial AgNPs	385:404	iturin-AgNPs was previously found to have much higher antibacterial activity at lower AgNPs content than the commercial AgNPs.
33892035	0	24	theme	Antibacterial	0:12	arg1	effect					42:47	Antibacterial and wound healing-promoting effect	0:47	effect	42:47	Antibacterial and wound healing-promoting effect of sponge-like chitosan-loaded silver nanoparticles biosynthesized by iturin.
33892035	7	25	theme	re-epithelialization	1171:1190	arg1	activity					1254:1261	the increased antibacerial activity	1227:1261	the increased antibacerial activity	1227:1261	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	7	25	theme	re-epithelialization	1171:1190	arg1	enhancement					1156:1166	the enhancement	1152:1166	the enhancement of re-epithelialization and collagen formation	1152:1213	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	7	25	theme	re-epithelialization	1171:1190	arg1	mechanisms					1053:1062	The mechanisms	1049:1062	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs	1049:1136	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	4	26	theme	water	708:712	arg1	porosity					695:702	high porosity	690:702	high porosity	690:702	As results, the synthesized CS dressing had high porosity and water absorption.
33892035	4	26	theme	water	708:712	arg1	results					649:655	results	649:655	results	649:655	As results, the synthesized CS dressing had high porosity and water absorption.
33892035	4	26	theme	water	708:712	arg1	absorption					714:723	water absorption	708:723	water absorption	708:723	As results, the synthesized CS dressing had high porosity and water absorption.
33892035	9	27	theme	CS	1387:1388	arg1	AgNPs					1406:1410	CS dressing loaded AgNPs	1387:1410	CS dressing loaded AgNPs	1387:1410	The study developed an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application.
33892035	3	28	theme	antibacterial	578:590	arg1	activity					592:599	their antibacterial activity	572:599	their antibacterial activity	572:599	To verify its potential application in the promotion of wound healing, a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs was developed and evaluated for their antibacterial activity in vitro and used for wound healing in vivo.
33892035	9	29	theme	wound	1458:1462	arg1	application					1469:1479	wound care application	1458:1479	wound care application	1458:1479	The study developed an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application.
33892035	0	30	theme	healing-promoting	24:40	arg1	effect					42:47	Antibacterial and wound healing-promoting effect	0:47	effect	42:47	Antibacterial and wound healing-promoting effect of sponge-like chitosan-loaded silver nanoparticles biosynthesized by iturin.
33892035	9	31	contain	has	1435:1437	arg2	potential					1445:1453	great potential	1439:1453	great potential	1439:1453	The study developed an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application.
33892035	9	31	contain	has	1435:1437	arg1	toxicity					1419:1426	low toxicity	1415:1426	low toxicity	1415:1426	The study developed an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application.
33892035	7	32	theme	wound	1085:1089	arg1	healing					1091:1097	wound healing	1085:1097	wound healing	1085:1097	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	1	33	theme	Silver	127:132	arg1	AgNPs					149:153	AgNPs	149:153	AgNPs	149:153	Silver nanoparticles (AgNPs) are widely used in wound dressing, but are limited in the application due to its high toxicity at effective concentrations.
33892035	1	33	theme	Silver	127:132	arg1	nanoparticles					134:146	Silver nanoparticles	127:146	Silver nanoparticles (AgNPs)	127:154	Silver nanoparticles (AgNPs) are widely used in wound dressing, but are limited in the application due to its high toxicity at effective concentrations.
33892035	3	34	theme	healing	469:475	arg1	promotion					450:458	the promotion	446:458	the promotion of wound healing	446:475	To verify its potential application in the promotion of wound healing, a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs was developed and evaluated for their antibacterial activity in vitro and used for wound healing in vivo.
33892035	0	35	theme	wound	18:22	arg1	effect					42:47	Antibacterial and wound healing-promoting effect	0:47	effect	42:47	Antibacterial and wound healing-promoting effect of sponge-like chitosan-loaded silver nanoparticles biosynthesized by iturin.
33892035	6	36	theme	quality	984:990	arg1	inhibition					904:913	more effective inhibition	889:913	more effective inhibition of bacterial infection	889:936	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	6	36	theme	quality	984:990	arg1	promotion					942:950	promotion	942:950	promotion of wound healing processing and quality	942:990	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	1	37	from	concentrations	264:277	arg1	toxicity					242:249	its high toxicity	233:249	its high toxicity at effective concentrations	233:277	Silver nanoparticles (AgNPs) are widely used in wound dressing, but are limited in the application due to its high toxicity at effective concentrations.
33892035	1	38	theme	wound	175:179	arg1	dressing					181:188	wound dressing	175:188	wound dressing	175:188	Silver nanoparticles (AgNPs) are widely used in wound dressing, but are limited in the application due to its high toxicity at effective concentrations.
33892035	5	39	theme	iturin-AgNPs	832:843	arg1	incorporation					815:827	the incorporation	811:827	the incorporation of iturin-AgNPs	811:843	As expected, the antibacterial activity of CS dressing was significantly promoted by the incorporation of iturin-AgNPs.
33892035	5	40	theme	CS	769:770	arg1	dressing					772:779	CS dressing	769:779	CS dressing	769:779	As expected, the antibacterial activity of CS dressing was significantly promoted by the incorporation of iturin-AgNPs.
33892035	9	41	theme	efficient	1332:1340	arg1	way					1342:1344	an efficient way	1329:1344	an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application	1329:1479	The study developed an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application.
33892035	9	42	from	toxicity	1419:1426	arg1	activity					1375:1382	the antibacterial activity	1357:1382	the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application	1357:1479	The study developed an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application.
33892035	3	43	theme	potential	421:429	arg1	application					431:441	its potential application	417:441	its potential application in the promotion of wound healing	417:475	To verify its potential application in the promotion of wound healing, a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs was developed and evaluated for their antibacterial activity in vitro and used for wound healing in vivo.
33892035	6	44	theme	processing	969:978	arg1	inhibition					904:913	more effective inhibition	889:913	more effective inhibition of bacterial infection	889:936	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	6	44	theme	processing	969:978	arg1	promotion					942:950	promotion	942:950	promotion of wound healing processing and quality	942:990	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	5	45	theme	dressing	772:779	arg1	activity					757:764	the antibacterial activity	739:764	the antibacterial activity of CS dressing	739:779	As expected, the antibacterial activity of CS dressing was significantly promoted by the incorporation of iturin-AgNPs.
33892035	6	46	theme	dressing-loaded	853:867	arg1	iturin-AgNPs					869:880	The CS dressing-loaded iturin-AgNPs	846:880	The CS dressing-loaded iturin-AgNPs	846:880	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	3	47	theme	wound	463:467	arg1	healing					469:475	wound healing	463:475	wound healing	463:475	To verify its potential application in the promotion of wound healing, a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs was developed and evaluated for their antibacterial activity in vitro and used for wound healing in vivo.
33892035	0	48	theme	chitosan-loaded	64:78	arg1	nanoparticles					87:99	sponge-like chitosan-loaded silver nanoparticles	52:99	sponge-like chitosan-loaded silver nanoparticles	52:99	Antibacterial and wound healing-promoting effect of sponge-like chitosan-loaded silver nanoparticles biosynthesized by iturin.
33892035	6	49	theme	healing	961:967	arg1	processing					969:978	wound healing processing	955:978	wound healing processing	955:978	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	5	50	theme	antibacterial	743:755	arg1	activity					757:764	the antibacterial activity	739:764	the antibacterial activity of CS dressing	739:779	As expected, the antibacterial activity of CS dressing was significantly promoted by the incorporation of iturin-AgNPs.
33892035	1	51	from	application	214:224	arg1	limited					199:205	limited	199:205	limited	199:205	Silver nanoparticles (AgNPs) are widely used in wound dressing, but are limited in the application due to its high toxicity at effective concentrations.
33892035	0	52	theme	sponge-like	52:62	arg1	nanoparticles					87:99	sponge-like chitosan-loaded silver nanoparticles	52:99	sponge-like chitosan-loaded silver nanoparticles	52:99	Antibacterial and wound healing-promoting effect of sponge-like chitosan-loaded silver nanoparticles biosynthesized by iturin.
33892035	2	53	contain	have	317:320	arg1	iturin-AgNPs					280:291	iturin-AgNPs	280:291	iturin-AgNPs	280:291	iturin-AgNPs was previously found to have much higher antibacterial activity at lower AgNPs content than the commercial AgNPs.
33892035	2	53	contain	have	317:320	arg2	activity					348:355	much higher antibacterial activity	322:355	much higher antibacterial activity	322:355	iturin-AgNPs was previously found to have much higher antibacterial activity at lower AgNPs content than the commercial AgNPs.
33892035	1	54	from	limited	199:205	arg1	application					214:224	the application	210:224	the application due to its high toxicity at effective concentrations	210:277	Silver nanoparticles (AgNPs) are widely used in wound dressing, but are limited in the application due to its high toxicity at effective concentrations.
33892035	8	55	theme	mice	1303:1306	arg1	organs					1293:1298	all organs	1289:1298	all organs of mice	1289:1306	No toxicity was found to all organs of mice.
33892035	9	56	theme	dressing	1390:1397	arg1	AgNPs					1406:1410	CS dressing loaded AgNPs	1387:1410	CS dressing loaded AgNPs	1387:1410	The study developed an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application.
33892035	3	57	theme	composite	494:502	arg1	iturin-AgNPs					527:538	a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs	478:538	a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs	478:538	To verify its potential application in the promotion of wound healing, a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs was developed and evaluated for their antibacterial activity in vitro and used for wound healing in vivo.
33892035	3	58	theme	wound	623:627	arg1	healing					629:635	wound healing	623:635	wound healing	623:635	To verify its potential application in the promotion of wound healing, a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs was developed and evaluated for their antibacterial activity in vitro and used for wound healing in vivo.
33892035	4	59	theme	CS	674:675	arg1	dressing					677:684	the synthesized CS dressing	658:684	the synthesized CS dressing	658:684	As results, the synthesized CS dressing had high porosity and water absorption.
33892035	2	60	theme	antibacterial	334:346	arg1	activity					348:355	much higher antibacterial activity	322:355	much higher antibacterial activity	322:355	iturin-AgNPs was previously found to have much higher antibacterial activity at lower AgNPs content than the commercial AgNPs.
33892035	9	61	theme	loaded	1399:1404	arg1	AgNPs					1406:1410	CS dressing loaded AgNPs	1387:1410	CS dressing loaded AgNPs	1387:1410	The study developed an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application.
33892035	6	62	theme	wound	1012:1016	arg1	AgNPs					1034:1038	the commercial wound dressing loaded AgNPs	997:1038	the commercial wound dressing loaded AgNPs	997:1038	The CS dressing-loaded iturin-AgNPs showed more effective inhibition of bacterial infection and promotion of wound healing processing and quality than the commercial wound dressing loaded AgNPs in vivo.
33892035	3	63	from	application	431:441	arg1	promotion					450:458	the promotion	446:458	the promotion of wound healing	446:475	To verify its potential application in the promotion of wound healing, a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs was developed and evaluated for their antibacterial activity in vitro and used for wound healing in vivo.
33892035	2	64	theme	higher	327:332	arg1	activity					348:355	much higher antibacterial activity	322:355	much higher antibacterial activity	322:355	iturin-AgNPs was previously found to have much higher antibacterial activity at lower AgNPs content than the commercial AgNPs.
33892035	9	65	theme	AgNPs	1406:1410	arg1	activity					1375:1382	the antibacterial activity	1357:1382	the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application	1357:1479	The study developed an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application.
33892035	0	66	theme	nanoparticles	87:99	arg1	effect					42:47	Antibacterial and wound healing-promoting effect	0:47	effect	42:47	Antibacterial and wound healing-promoting effect of sponge-like chitosan-loaded silver nanoparticles biosynthesized by iturin.
33892035	9	67	theme	care	1464:1467	arg1	application					1469:1479	wound care application	1458:1479	wound care application	1458:1479	The study developed an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application.
33892035	3	68	theme	sponge	504:509	arg1	iturin-AgNPs					527:538	a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs	478:538	a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs	478:538	To verify its potential application in the promotion of wound healing, a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs was developed and evaluated for their antibacterial activity in vitro and used for wound healing in vivo.
33892035	9	69	theme	antibacterial	1361:1373	arg1	activity					1375:1382	the antibacterial activity	1357:1382	the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application	1357:1479	The study developed an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application.
33892035	0	70	theme	silver	80:85	arg1	nanoparticles					87:99	sponge-like chitosan-loaded silver nanoparticles	52:99	sponge-like chitosan-loaded silver nanoparticles	52:99	Antibacterial and wound healing-promoting effect of sponge-like chitosan-loaded silver nanoparticles biosynthesized by iturin.
33892035	4	71	contain	had	686:688	arg2	absorption					714:723	water absorption	708:723	water absorption	708:723	As results, the synthesized CS dressing had high porosity and water absorption.
33892035	4	71	contain	had	686:688	arg2	results					649:655	results	649:655	results	649:655	As results, the synthesized CS dressing had high porosity and water absorption.
33892035	4	71	contain	had	686:688	arg1	dressing					677:684	the synthesized CS dressing	658:684	the synthesized CS dressing	658:684	As results, the synthesized CS dressing had high porosity and water absorption.
33892035	4	71	contain	had	686:688	arg2	porosity					695:702	high porosity	690:702	high porosity	690:702	As results, the synthesized CS dressing had high porosity and water absorption.
33892035	7	72	theme	collagen	1196:1203	arg1	formation					1205:1213	collagen formation	1196:1213	collagen formation	1196:1213	The mechanisms for the promotion of wound healing by the CS dressing-loaded iturin-AgNPs were found as the enhancement of re-epithelialization and collagen formation, as well as the increased antibacerial activity.
33892035	3	73	used	used	614:617	arg2	iturin-AgNPs					527:538	a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs	478:538	a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs	478:538	To verify its potential application in the promotion of wound healing, a chitosan (CS) composite sponge dressing-loaded iturin-AgNPs was developed and evaluated for their antibacterial activity in vitro and used for wound healing in vivo.
33892035	9	74	theme	low	1415:1417	arg1	toxicity					1419:1426	low toxicity	1415:1426	low toxicity	1415:1426	The study developed an efficient way to enhance the antibacterial activity of CS dressing loaded AgNPs at low toxicity, which has great potential in wound care application.
33892035	1	75	theme	high	237:240	arg1	toxicity					242:249	its high toxicity	233:249	its high toxicity at effective concentrations	233:277	Silver nanoparticles (AgNPs) are widely used in wound dressing, but are limited in the application due to its high toxicity at effective concentrations.
34175516	6	0	theme	surface	1011:1017	arg1	charge					1019:1024	surface charge	1011:1024	surface charge	1011:1024	The membrane characterization confirmed the enhanced surface roughness, pore size, surface charge, and hydrophilicity.
34175516	3	1	theme	stable	480:485	arg1	MOFs					512:515	MOFs	512:515	MOFs	512:515	Incorporating a highly water stable metal-organic framework (MOFs) into membranes would meet the requirements for the efficient purification of textile wastewater.
34175516	3	1	theme	stable	480:485	arg1	framework					501:509	a highly water stable metal-organic framework	465:509	a highly water stable metal-organic framework (MOFs)	465:516	Incorporating a highly water stable metal-organic framework (MOFs) into membranes would meet the requirements for the efficient purification of textile wastewater.
34175516	9	2	theme	high	1585:1588	arg1	stability					1600:1608	high recycling stability	1585:1608	high recycling stability	1585:1608	In addition, the CS/MIL-100 (Fe) composite membrane showed excellent rejection efficiency and antifouling performances with high recycling stability.
34175516	9	3	with	efficiency	1540:1549	arg1	stability					1600:1608	high recycling stability	1585:1608	high recycling stability	1585:1608	In addition, the CS/MIL-100 (Fe) composite membrane showed excellent rejection efficiency and antifouling performances with high recycling stability.
34175516	4	4	theme	nanofiltration	630:643	arg1	membranes					650:658	nanofiltration (NF) membranes	630:658	nanofiltration (NF) membranes	630:658	In this study, nanofiltration (NF) membranes are fabricated by incorporating MIL-100 (Fe) into the chitosan (CS) through film casting technique.
34175516	7	5	theme	improved	1089:1096	arg1	flux					1109:1112	an improved pure water flux	1086:1112	an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO)	1086:1231	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	1	6	theme	hazardous	150:158	arg1	wastewater					175:184	hazardous textile dyeing wastewater	150:184	hazardous textile dyeing wastewater	150:184	The purification of hazardous textile dyeing wastewater has exhibited many challenges because it consists of a complex mixture, including dyestuff, additives, and salts.
34175516	10	7	theme	Fe	1665:1666	arg1	candidate					1708:1716	a promising candidate	1696:1716	a promising candidate for removing toxic pollutants in the textile dyeing wastewater	1696:1779	These stunning results evidenced that the CS/MIL-100 (Fe) nanofiltration membrane is a promising candidate for removing toxic pollutants in the textile dyeing wastewater.
34175516	10	7	theme	Fe	1665:1666	arg1	membrane					1684:1691	the CS/MIL-100 (Fe) nanofiltration membrane	1649:1691	the CS/MIL-100 (Fe) nanofiltration membrane	1649:1691	These stunning results evidenced that the CS/MIL-100 (Fe) nanofiltration membrane is a promising candidate for removing toxic pollutants in the textile dyeing wastewater.
34175516	1	8	theme	dyeing	168:173	arg1	wastewater					175:184	hazardous textile dyeing wastewater	150:184	hazardous textile dyeing wastewater	150:184	The purification of hazardous textile dyeing wastewater has exhibited many challenges because it consists of a complex mixture, including dyestuff, additives, and salts.
34175516	10	9	theme	CS/MIL-100	1653:1662	arg1	candidate					1708:1716	a promising candidate	1696:1716	a promising candidate for removing toxic pollutants in the textile dyeing wastewater	1696:1779	These stunning results evidenced that the CS/MIL-100 (Fe) nanofiltration membrane is a promising candidate for removing toxic pollutants in the textile dyeing wastewater.
34175516	10	9	theme	CS/MIL-100	1653:1662	arg1	membrane					1684:1691	the CS/MIL-100 (Fe) nanofiltration membrane	1649:1691	the CS/MIL-100 (Fe) nanofiltration membrane	1649:1691	These stunning results evidenced that the CS/MIL-100 (Fe) nanofiltration membrane is a promising candidate for removing toxic pollutants in the textile dyeing wastewater.
34175516	0	10	theme	based	99:103	arg1	membrane					120:127	a novel CS/MIL-100 (Fe) based nanofiltration membrane	75:127	a novel CS/MIL-100 (Fe) based nanofiltration membrane	75:127	Efficient removal of anionic, cationic textile dyes and salt mixture using a novel CS/MIL-100 (Fe) based nanofiltration membrane.
34175516	3	11	theme	efficient	569:577	arg1	purification					579:590	the efficient purification	565:590	the efficient purification of textile wastewater	565:612	Incorporating a highly water stable metal-organic framework (MOFs) into membranes would meet the requirements for the efficient purification of textile wastewater.
34175516	1	12	theme	many	200:203	arg1	challenges					205:214	exhibited many challenges	190:214	exhibited many challenges	190:214	The purification of hazardous textile dyeing wastewater has exhibited many challenges because it consists of a complex mixture, including dyestuff, additives, and salts.
34175516	10	13	theme	nanofiltration	1669:1682	arg1	candidate					1708:1716	a promising candidate	1696:1716	a promising candidate for removing toxic pollutants in the textile dyeing wastewater	1696:1779	These stunning results evidenced that the CS/MIL-100 (Fe) nanofiltration membrane is a promising candidate for removing toxic pollutants in the textile dyeing wastewater.
34175516	10	13	theme	nanofiltration	1669:1682	arg1	membrane					1684:1691	the CS/MIL-100 (Fe) nanofiltration membrane	1649:1691	the CS/MIL-100 (Fe) nanofiltration membrane	1649:1691	These stunning results evidenced that the CS/MIL-100 (Fe) nanofiltration membrane is a promising candidate for removing toxic pollutants in the textile dyeing wastewater.
34175516	5	14	theme	contact	837:843	arg1	measurement					851:861	contact angle measurement	837:861	contact angle measurement	837:861	The effect of MIL-100 (Fe) loadings on chitosan characterized by FT-IR, XRD, contact angle measurement, FESEM-EDS, XPS, zeta potential, and surface roughness analysis.
34175516	8	15	theme	MgSO4	1316:1320	arg1	 > Na2SO4					1351:1359	MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4	1316:1359	MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%)	1316:1458	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	3	16	theme	wastewater	603:612	arg1	purification					579:590	the efficient purification	565:590	the efficient purification of textile wastewater	565:612	Incorporating a highly water stable metal-organic framework (MOFs) into membranes would meet the requirements for the efficient purification of textile wastewater.
34175516	6	17	theme	membrane	932:939	arg1	characterization					941:956	The membrane characterization	928:956	The membrane characterization	928:956	The membrane characterization confirmed the enhanced surface roughness, pore size, surface charge, and hydrophilicity.
34175516	10	18	theme	promising	1698:1706	arg1	candidate					1708:1716	a promising candidate	1696:1716	a promising candidate for removing toxic pollutants in the textile dyeing wastewater	1696:1779	These stunning results evidenced that the CS/MIL-100 (Fe) nanofiltration membrane is a promising candidate for removing toxic pollutants in the textile dyeing wastewater.
34175516	10	18	theme	promising	1698:1706	arg1	membrane					1684:1691	the CS/MIL-100 (Fe) nanofiltration membrane	1649:1691	the CS/MIL-100 (Fe) nanofiltration membrane	1649:1691	These stunning results evidenced that the CS/MIL-100 (Fe) nanofiltration membrane is a promising candidate for removing toxic pollutants in the textile dyeing wastewater.
34175516	0	19	theme	mixture	61:67	arg1	removal					10:16	Efficient removal	0:16	Efficient removal of anionic, cationic textile dyes and salt mixture	0:67	Efficient removal of anionic, cationic textile dyes and salt mixture using a novel CS/MIL-100 (Fe) based nanofiltration membrane.
34175516	10	20	theme	toxic	1731:1735	arg1	pollutants					1737:1746	toxic pollutants	1731:1746	toxic pollutants	1731:1746	These stunning results evidenced that the CS/MIL-100 (Fe) nanofiltration membrane is a promising candidate for removing toxic pollutants in the textile dyeing wastewater.
34175516	5	21	from	effect	764:769	arg1	chitosan					799:806	chitosan	799:806	chitosan	799:806	The effect of MIL-100 (Fe) loadings on chitosan characterized by FT-IR, XRD, contact angle measurement, FESEM-EDS, XPS, zeta potential, and surface roughness analysis.
34175516	5	22	theme	zeta	880:883	arg1	potential					885:893	zeta potential	880:893	zeta potential	880:893	The effect of MIL-100 (Fe) loadings on chitosan characterized by FT-IR, XRD, contact angle measurement, FESEM-EDS, XPS, zeta potential, and surface roughness analysis.
34175516	2	23	theme	fouling	367:373	arg1	resistance					375:384	fouling resistance	367:384	fouling resistance	367:384	It is necessary to fabricate membranes with enhanced permeability, fouling resistance, stability, and superior dyes and salts removal from wastewater.
34175516	7	24	theme	water	1103:1107	arg1	flux					1109:1112	an improved pure water flux	1086:1112	an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO)	1086:1231	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	7	25	theme	methyl	1214:1219	arg1	MO					1229:1230	MO	1229:1230	MO	1229:1230	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	7	25	theme	methyl	1214:1219	arg1	orange					1221:1226	anionic methyl orange	1206:1226	anionic methyl orange (MO)	1206:1231	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	0	26	theme	Efficient	0:8	arg1	removal					10:16	Efficient removal	0:16	Efficient removal of anionic, cationic textile dyes and salt mixture	0:67	Efficient removal of anionic, cationic textile dyes and salt mixture using a novel CS/MIL-100 (Fe) based nanofiltration membrane.
34175516	2	27	theme	superior	402:409	arg1	dyes					411:414	superior dyes	402:414	superior dyes	402:414	It is necessary to fabricate membranes with enhanced permeability, fouling resistance, stability, and superior dyes and salts removal from wastewater.
34175516	8	28	theme	 > Na2SO4	1351:1359	arg1	 > CaCl2					1389:1396	MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2	1316:1396	MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%)	1316:1458	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	8	29	dep	 > NaCl	1425:1431	arg1	Na+					1434:1436	Na+	1434:1436	Na+	1434:1436	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	8	29	dep	 > NaCl	1425:1431	arg1	%					1444:1444	16.8%	1440:1444	16.8%	1440:1444	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	8	29	dep	 > NaCl	1425:1431	arg1	%					1457:1457	19.2%	1453:1457	19.2%	1453:1457	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	8	29	dep	 > NaCl	1425:1431	arg1	Cl-					1447:1449	Cl-	1447:1449	Cl-	1447:1449	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	6	30	theme	enhanced	972:979	arg1	roughness					989:997	surface roughness	981:997	surface roughness	981:997	The membrane characterization confirmed the enhanced surface roughness, pore size, surface charge, and hydrophilicity.
34175516	8	31	from	trend	1271:1275	arg1	order					1307:1311	the order	1303:1311	the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%)	1303:1458	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	7	32	dep	52 L/m2h	1124:1131	arg1	to					1121:1122	to	1121:1122	to	1121:1122	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	8	33	theme	efficiency	1260:1269	arg1	trend					1271:1275	the rejection efficiency trend	1246:1275	the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%)	1246:1458	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	7	34	theme	blue	1192:1195	arg1	methylene					1182:1190	cationic methylene blue	1173:1195	cationic methylene blue (MB)	1173:1200	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	7	34	theme	blue	1192:1195	arg1	MB					1198:1199	MB	1198:1199	MB	1198:1199	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	0	35	theme	textile	39:45	arg1	dyes					47:50	anionic, cationic textile dyes	21:50	anionic, cationic textile dyes	21:50	Efficient removal of anionic, cationic textile dyes and salt mixture using a novel CS/MIL-100 (Fe) based nanofiltration membrane.
34175516	7	36	theme	cationic	1173:1180	arg1	methylene					1182:1190	cationic methylene blue	1173:1195	cationic methylene blue (MB)	1173:1200	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	7	36	theme	cationic	1173:1180	arg1	MB					1198:1199	MB	1198:1199	MB	1198:1199	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	9	37	theme	excellent	1520:1528	arg1	efficiency					1540:1549	excellent rejection efficiency	1520:1549	excellent rejection efficiency	1520:1549	In addition, the CS/MIL-100 (Fe) composite membrane showed excellent rejection efficiency and antifouling performances with high recycling stability.
34175516	4	38	theme	film	736:739	arg1	technique					749:757	film casting technique	736:757	film casting technique	736:757	In this study, nanofiltration (NF) membranes are fabricated by incorporating MIL-100 (Fe) into the chitosan (CS) through film casting technique.
34175516	5	39	theme	surface	900:906	arg1	analysis					918:925	surface roughness analysis	900:925	surface roughness analysis	900:925	The effect of MIL-100 (Fe) loadings on chitosan characterized by FT-IR, XRD, contact angle measurement, FESEM-EDS, XPS, zeta potential, and surface roughness analysis.
34175516	10	40	theme	textile	1755:1761	arg1	wastewater					1770:1779	the textile dyeing wastewater	1751:1779	the textile dyeing wastewater	1751:1779	These stunning results evidenced that the CS/MIL-100 (Fe) nanofiltration membrane is a promising candidate for removing toxic pollutants in the textile dyeing wastewater.
34175516	3	41	theme	metal-organic	487:499	arg1	MOFs					512:515	MOFs	512:515	MOFs	512:515	Incorporating a highly water stable metal-organic framework (MOFs) into membranes would meet the requirements for the efficient purification of textile wastewater.
34175516	3	41	theme	metal-organic	487:499	arg1	framework					501:509	a highly water stable metal-organic framework	465:509	a highly water stable metal-organic framework (MOFs)	465:516	Incorporating a highly water stable metal-organic framework (MOFs) into membranes would meet the requirements for the efficient purification of textile wastewater.
34175516	7	42	theme	CS/MIL-100	1051:1060	arg1	membrane					1067:1074	The CS/MIL-100 (Fe) membrane	1047:1074	The CS/MIL-100 (Fe) membrane	1047:1074	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	7	43	theme	%	1146:1146	arg1	efficiency					1158:1167	99% rejection efficiency	1144:1167	an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO)	1086:1231	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	9	44	theme	antifouling	1555:1565	arg1	performances					1567:1578	antifouling performances	1555:1578	antifouling performances with high recycling stability	1555:1608	In addition, the CS/MIL-100 (Fe) composite membrane showed excellent rejection efficiency and antifouling performances with high recycling stability.
34175516	8	45	theme	 > CaCl2	1389:1396	arg1	 > NaCl					1425:1431	MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl	1316:1431	MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%)	1316:1458	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	9	46	with	performances	1567:1578	arg1	stability					1600:1608	high recycling stability	1585:1608	high recycling stability	1585:1608	In addition, the CS/MIL-100 (Fe) composite membrane showed excellent rejection efficiency and antifouling performances with high recycling stability.
34175516	1	47	theme	complex	241:247	arg1	mixture					249:255	a complex mixture	239:255	a complex mixture	239:255	The purification of hazardous textile dyeing wastewater has exhibited many challenges because it consists of a complex mixture, including dyestuff, additives, and salts.
34175516	9	48	theme	recycling	1590:1598	arg1	stability					1600:1608	high recycling stability	1585:1608	high recycling stability	1585:1608	In addition, the CS/MIL-100 (Fe) composite membrane showed excellent rejection efficiency and antifouling performances with high recycling stability.
34175516	8	49	theme	 > NaCl	1425:1431	arg1	order					1307:1311	the order	1303:1311	the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%)	1303:1458	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	5	50	theme	loadings	787:794	arg1	effect					764:769	The effect	760:769	The effect of MIL-100 (Fe) loadings on chitosan	760:806	The effect of MIL-100 (Fe) loadings on chitosan characterized by FT-IR, XRD, contact angle measurement, FESEM-EDS, XPS, zeta potential, and surface roughness analysis.
34175516	10	51	theme	stunning	1617:1624	arg1	results					1626:1632	These stunning results	1611:1632	These stunning results	1611:1632	These stunning results evidenced that the CS/MIL-100 (Fe) nanofiltration membrane is a promising candidate for removing toxic pollutants in the textile dyeing wastewater.
34175516	1	52	theme	textile	160:166	arg1	wastewater					175:184	hazardous textile dyeing wastewater	150:184	hazardous textile dyeing wastewater	150:184	The purification of hazardous textile dyeing wastewater has exhibited many challenges because it consists of a complex mixture, including dyestuff, additives, and salts.
34175516	1	53	theme	wastewater	175:184	arg1	purification					134:145	The purification	130:145	The purification of hazardous textile dyeing wastewater	130:184	The purification of hazardous textile dyeing wastewater has exhibited many challenges because it consists of a complex mixture, including dyestuff, additives, and salts.
34175516	0	54	theme	nanofiltration	105:118	arg1	membrane					120:127	a novel CS/MIL-100 (Fe) based nanofiltration membrane	75:127	a novel CS/MIL-100 (Fe) based nanofiltration membrane	75:127	Efficient removal of anionic, cationic textile dyes and salt mixture using a novel CS/MIL-100 (Fe) based nanofiltration membrane.
34175516	1	55	theme	exhibited	190:198	arg1	challenges					205:214	exhibited many challenges	190:214	exhibited many challenges	190:214	The purification of hazardous textile dyeing wastewater has exhibited many challenges because it consists of a complex mixture, including dyestuff, additives, and salts.
34175516	8	56	dep	Na+	1362:1364	arg1	%					1387:1387	29.3%	1383:1387	29.3%	1383:1387	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	8	56	dep	Na+	1362:1364	arg1	%					1372:1372	26.3%	1368:1372	26.3%	1368:1372	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	8	56	dep	Na+	1362:1364	arg1	SO42-					1375:1379	SO42-	1375:1379	SO42-	1375:1379	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	3	57	theme	textile	595:601	arg1	wastewater					603:612	textile wastewater	595:612	textile wastewater	595:612	Incorporating a highly water stable metal-organic framework (MOFs) into membranes would meet the requirements for the efficient purification of textile wastewater.
34175516	5	58	theme	angle	845:849	arg1	measurement					851:861	contact angle measurement	837:861	contact angle measurement	837:861	The effect of MIL-100 (Fe) loadings on chitosan characterized by FT-IR, XRD, contact angle measurement, FESEM-EDS, XPS, zeta potential, and surface roughness analysis.
34175516	7	59	from	52 L/m2h	1124:1131	arg1	flux					1109:1112	an improved pure water flux	1086:1112	an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO)	1086:1231	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	7	59	from	52 L/m2h	1124:1131	arg1	efficiency					1158:1167	99% rejection efficiency	1144:1167	an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO)	1086:1231	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	0	60	theme	salt	56:59	arg1	mixture					61:67	salt mixture	56:67	salt mixture	56:67	Efficient removal of anionic, cationic textile dyes and salt mixture using a novel CS/MIL-100 (Fe) based nanofiltration membrane.
34175516	8	61	dep	 > Na2SO4	1351:1359	arg1	Na+					1362:1364	Na+	1362:1364	Na+	1362:1364	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	2	62	with	salts	420:424	arg1	dyes					411:414	superior dyes	402:414	superior dyes	402:414	It is necessary to fabricate membranes with enhanced permeability, fouling resistance, stability, and superior dyes and salts removal from wastewater.
34175516	2	62	with	salts	420:424	arg1	stability					387:395	stability	387:395	stability	387:395	It is necessary to fabricate membranes with enhanced permeability, fouling resistance, stability, and superior dyes and salts removal from wastewater.
34175516	2	62	with	salts	420:424	arg1	permeability					353:364	enhanced permeability	344:364	enhanced permeability	344:364	It is necessary to fabricate membranes with enhanced permeability, fouling resistance, stability, and superior dyes and salts removal from wastewater.
34175516	2	62	with	salts	420:424	arg1	resistance					375:384	fouling resistance	367:384	fouling resistance	367:384	It is necessary to fabricate membranes with enhanced permeability, fouling resistance, stability, and superior dyes and salts removal from wastewater.
34175516	10	63	theme	dyeing	1763:1768	arg1	wastewater					1770:1779	the textile dyeing wastewater	1751:1779	the textile dyeing wastewater	1751:1779	These stunning results evidenced that the CS/MIL-100 (Fe) nanofiltration membrane is a promising candidate for removing toxic pollutants in the textile dyeing wastewater.
34175516	8	64	dep	Ca2+	1399:1402	arg1	Cl-					1413:1415	Cl-	1413:1415	Cl-	1413:1415	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	8	64	dep	Ca2+	1399:1402	arg1	%					1423:1423	23.8%	1419:1423	23.8%	1419:1423	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	8	64	dep	Ca2+	1399:1402	arg1	%					1410:1410	21.4%	1406:1410	21.4%	1406:1410	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	0	65	theme	novel	77:81	arg1	membrane					120:127	a novel CS/MIL-100 (Fe) based nanofiltration membrane	75:127	a novel CS/MIL-100 (Fe) based nanofiltration membrane	75:127	Efficient removal of anionic, cationic textile dyes and salt mixture using a novel CS/MIL-100 (Fe) based nanofiltration membrane.
34175516	8	66	dep	 > CaCl2	1389:1396	arg1	Ca2+					1399:1402	Ca2+	1399:1402	Ca2+	1399:1402	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	7	67	theme	pure	1098:1101	arg1	flux					1109:1112	an improved pure water flux	1086:1112	an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO)	1086:1231	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	7	68	theme	anionic	1206:1212	arg1	MO					1229:1230	MO	1229:1230	MO	1229:1230	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	7	68	theme	anionic	1206:1212	arg1	orange					1221:1226	anionic methyl orange	1206:1226	anionic methyl orange (MO)	1206:1231	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	2	69	from	wastewater	439:448	arg1	removal					426:432	removal	426:432	removal from wastewater	426:448	It is necessary to fabricate membranes with enhanced permeability, fouling resistance, stability, and superior dyes and salts removal from wastewater.
34175516	2	70	dep	membranes	329:337	arg1	removal					426:432	removal	426:432	removal from wastewater	426:448	It is necessary to fabricate membranes with enhanced permeability, fouling resistance, stability, and superior dyes and salts removal from wastewater.
34175516	2	71	theme	enhanced	344:351	arg1	permeability					353:364	enhanced permeability	344:364	enhanced permeability	344:364	It is necessary to fabricate membranes with enhanced permeability, fouling resistance, stability, and superior dyes and salts removal from wastewater.
34175516	0	72	theme	anionic	21:27	arg1	dyes					47:50	anionic, cationic textile dyes	21:50	anionic, cationic textile dyes	21:50	Efficient removal of anionic, cationic textile dyes and salt mixture using a novel CS/MIL-100 (Fe) based nanofiltration membrane.
34175516	8	73	dep	Mg2+	1323:1326	arg1	SO42-					1337:1341	SO42-	1337:1341	SO42-	1337:1341	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	8	73	dep	Mg2+	1323:1326	arg1	%					1349:1349	52.5%	1345:1349	52.5%	1345:1349	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	8	73	dep	Mg2+	1323:1326	arg1	%					1334:1334	51.6%	1330:1334	51.6%	1330:1334	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	6	74	theme	surface	981:987	arg1	roughness					989:997	surface roughness	981:997	surface roughness	981:997	The membrane characterization confirmed the enhanced surface roughness, pore size, surface charge, and hydrophilicity.
34175516	7	75	theme	Fe	1063:1064	arg1	membrane					1067:1074	The CS/MIL-100 (Fe) membrane	1047:1074	The CS/MIL-100 (Fe) membrane	1047:1074	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	8	76	dep	MgSO4	1316:1320	arg1	Mg2+					1323:1326	Mg2+	1323:1326	Mg2+	1323:1326	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	9	77	theme	composite	1494:1502	arg1	membrane					1504:1511	the CS/MIL-100 (Fe) composite membrane	1474:1511	the CS/MIL-100 (Fe) composite membrane	1474:1511	In addition, the CS/MIL-100 (Fe) composite membrane showed excellent rejection efficiency and antifouling performances with high recycling stability.
34175516	8	78	theme	rejection	1250:1258	arg1	trend					1271:1275	the rejection efficiency trend	1246:1275	the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%)	1246:1458	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
34175516	0	79	theme	dyes	47:50	arg1	removal					10:16	Efficient removal	0:16	Efficient removal of anionic, cationic textile dyes and salt mixture	0:67	Efficient removal of anionic, cationic textile dyes and salt mixture using a novel CS/MIL-100 (Fe) based nanofiltration membrane.
34175516	4	80	theme	casting	741:747	arg1	technique					749:757	film casting technique	736:757	film casting technique	736:757	In this study, nanofiltration (NF) membranes are fabricated by incorporating MIL-100 (Fe) into the chitosan (CS) through film casting technique.
34175516	0	81	dep	anionic	21:27	arg1	cationic					30:37	cationic	30:37	cationic	30:37	Efficient removal of anionic, cationic textile dyes and salt mixture using a novel CS/MIL-100 (Fe) based nanofiltration membrane.
34175516	7	82	theme	rejection	1148:1156	arg1	efficiency					1158:1167	99% rejection efficiency	1144:1167	an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO)	1086:1231	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	9	83	theme	rejection	1530:1538	arg1	efficiency					1540:1549	excellent rejection efficiency	1520:1549	excellent rejection efficiency	1520:1549	In addition, the CS/MIL-100 (Fe) composite membrane showed excellent rejection efficiency and antifouling performances with high recycling stability.
34175516	1	84	contain	has	186:188	arg2	challenges					205:214	exhibited many challenges	190:214	exhibited many challenges	190:214	The purification of hazardous textile dyeing wastewater has exhibited many challenges because it consists of a complex mixture, including dyestuff, additives, and salts.
34175516	1	84	contain	has	186:188	arg1	purification					134:145	The purification	130:145	The purification of hazardous textile dyeing wastewater	130:184	The purification of hazardous textile dyeing wastewater has exhibited many challenges because it consists of a complex mixture, including dyestuff, additives, and salts.
34175516	2	85	with	membranes	329:337	arg1	dyes					411:414	superior dyes	402:414	superior dyes	402:414	It is necessary to fabricate membranes with enhanced permeability, fouling resistance, stability, and superior dyes and salts removal from wastewater.
34175516	2	85	with	membranes	329:337	arg1	stability					387:395	stability	387:395	stability	387:395	It is necessary to fabricate membranes with enhanced permeability, fouling resistance, stability, and superior dyes and salts removal from wastewater.
34175516	2	85	with	membranes	329:337	arg1	permeability					353:364	enhanced permeability	344:364	enhanced permeability	344:364	It is necessary to fabricate membranes with enhanced permeability, fouling resistance, stability, and superior dyes and salts removal from wastewater.
34175516	2	85	with	membranes	329:337	arg1	resistance					375:384	fouling resistance	367:384	fouling resistance	367:384	It is necessary to fabricate membranes with enhanced permeability, fouling resistance, stability, and superior dyes and salts removal from wastewater.
34175516	5	86	theme	roughness	908:916	arg1	analysis					918:925	surface roughness analysis	900:925	surface roughness analysis	900:925	The effect of MIL-100 (Fe) loadings on chitosan characterized by FT-IR, XRD, contact angle measurement, FESEM-EDS, XPS, zeta potential, and surface roughness analysis.
34175516	7	87	theme	99	1144:1145	arg1	%					1146:1146	%	1146:1146	%	1146:1146	The CS/MIL-100 (Fe) membrane exhibited an improved pure water flux from 5 to 52 L/m2h as well as 99% rejection efficiency for cationic methylene blue (MB) and anionic methyl orange (MO).
34175516	6	88	theme	pore	1000:1003	arg1	size					1005:1008	pore size	1000:1008	pore size	1000:1008	The membrane characterization confirmed the enhanced surface roughness, pore size, surface charge, and hydrophilicity.
34175516	8	89	theme	mixed	1288:1292	arg1	salts					1294:1298	the MB mixed salts	1281:1298	the MB mixed salts	1281:1298	We obtained the rejection efficiency trend for the MB mixed salts in the order of MgSO4 (Mg2+ - 51.6%, SO42- - 52.5%) > Na2SO4 (Na+ - 26.3%, SO42- - 29.3%) > CaCl2 (Ca2+ - 21.4%, Cl- - 23.8%) > NaCl (Na+ - 16.8%, Cl- - 19.2%).
32755962	0	0	theme	biodistribution	76:90	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	0	0	theme	biodistribution	76:90	arg1	assessment					26:35	comparative assessment	14:35	comparative assessment	14:35	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	7	1	theme	selenium	1346:1353	arg1	nanoparticles					1355:1367	small selenium nanoparticles	1340:1367	small selenium nanoparticles (6.8 nm)	1340:1376	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	7	1	theme	selenium	1346:1353	arg1	6.8 nm					1370:1375	6.8 nm	1370:1375	6.8 nm	1370:1375	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	4	2	theme	emission/excitation	781:799	arg1	ranges					770:775	Optical ranges	762:775	Optical ranges of 'emission/excitation' of aqueous solutions of nanocomposites with Se0NPs of different sizes	762:870	Optical ranges of 'emission/excitation' of aqueous solutions of nanocomposites with Se0NPs of different sizes are established and the most important parameters of their luminescence are determined.
32755962	7	3	from	brain	1530:1534	arg1	amounts					1547:1553	lesser amounts	1540:1553	lesser amounts	1540:1553	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	7	4	theme	rats	1559:1562	arg1	kidneys					1517:1523	kidneys	1517:1523	kidneys	1517:1523	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	7	4	theme	rats	1559:1562	arg1	brain					1530:1534	brain	1530:1534	brain	1530:1534	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	7	4	theme	rats	1559:1562	arg1	liver					1510:1514	the liver	1506:1514	the liver	1506:1514	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	5	5	theme	expressed	997:1005	arg1	activity					1019:1026	the expressed antiradical activity	993:1026	the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid	993:1137	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	3	6	theme	composite	561:569	arg1	nanomaterials					571:583	these composite nanomaterials	555:583	these composite nanomaterials	555:583	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	0	7	theme	κ-carrageenan-capped	95:114	arg1	nanoparticles					125:137	κ-carrageenan-capped selenium nanoparticles	95:137	κ-carrageenan-capped selenium nanoparticles of different size	95:155	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	4	8	theme	different	856:864	arg1	sizes					866:870	different sizes	856:870	different sizes	856:870	Optical ranges of 'emission/excitation' of aqueous solutions of nanocomposites with Se0NPs of different sizes are established and the most important parameters of their luminescence are determined.
32755962	7	9	theme	small	1340:1344	arg1	nanoparticles					1355:1367	small selenium nanoparticles	1340:1367	small selenium nanoparticles (6.8 nm)	1340:1376	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	7	9	theme	small	1340:1344	arg1	6.8 nm					1370:1375	6.8 nm	1370:1375	6.8 nm	1370:1375	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	1	10	theme	base-reduction	385:398	arg1	2H4-NaOH					409:416	the base-reduction system 'N2H4-NaOH'	381:417	the base-reduction system 'N2H4-NaOH'	381:417	In the present study, water-soluble hybrid selenium-containing nanocomposites have been synthesised via soft oxidation of selenide-anions, preliminarily generated from elemental bulk-selenium in the base-reduction system 'N2H4-NaOH'.
32755962	5	11	dep	radicals	1041:1048	arg1	2,2'-azino-bis					1084:1097	2,2'-azino-bis	1084:1097	2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid	1084:1137	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	5	11	dep	radicals	1041:1048	arg1	2,2-diphenyl-1-picrylhydrazyl					1050:1078	2,2-diphenyl-1-picrylhydrazyl	1050:1078	2,2-diphenyl-1-picrylhydrazyl	1050:1078	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	5	11	dep	radicals	1041:1048	arg1	radicals					1041:1048	free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid	1036:1137	free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid	1036:1137	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	3	12	theme	complementary	607:619	arg1	methods					639:645	complementary physical-chemical methods	607:645	complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering	607:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	12	theme	complementary	607:619	arg1	spectroscopy					718:729	optical spectroscopy	710:729	optical spectroscopy	710:729	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	12	theme	complementary	607:619	arg1	analysis					666:673	X-ray diffraction analysis	648:673	X-ray diffraction analysis	648:673	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	12	theme	complementary	607:619	arg1	scattering					750:759	dynamic light scattering	736:759	dynamic light scattering	736:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	12	theme	complementary	607:619	arg1	microscopy					698:707	transmission electron microscopy	676:707	transmission electron microscopy	676:707	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	4	13	theme	aqueous	805:811	arg1	solutions					813:821	aqueous solutions	805:821	aqueous solutions of nanocomposites with Se0NPs of different sizes	805:870	Optical ranges of 'emission/excitation' of aqueous solutions of nanocomposites with Se0NPs of different sizes are established and the most important parameters of their luminescence are determined.
32755962	0	14	theme	nanoparticles	125:137	arg1	toxicity					62:69	toxicity	62:69	toxicity	62:69	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	0	14	theme	nanoparticles	125:137	arg1	biodistribution					76:90	biodistribution	76:90	biodistribution	76:90	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	0	14	theme	nanoparticles	125:137	arg1	activity					52:59	antiradical activity	40:59	antiradical activity	40:59	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	1	15	theme	system	400:405	arg1	2H4-NaOH					409:416	the base-reduction system 'N2H4-NaOH'	381:417	the base-reduction system 'N2H4-NaOH'	381:417	In the present study, water-soluble hybrid selenium-containing nanocomposites have been synthesised via soft oxidation of selenide-anions, preliminarily generated from elemental bulk-selenium in the base-reduction system 'N2H4-NaOH'.
32755962	7	16	dep	nanoparticles	1401:1413	arg1	contrast					1382:1389	contrast	1382:1389	contrast	1382:1389	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	5	17	theme	free	1036:1039	arg1	2,2'-azino-bis					1084:1097	2,2'-azino-bis	1084:1097	2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid	1084:1137	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	5	17	theme	free	1036:1039	arg1	2,2-diphenyl-1-picrylhydrazyl					1050:1078	2,2-diphenyl-1-picrylhydrazyl	1050:1078	2,2-diphenyl-1-picrylhydrazyl	1050:1078	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	5	17	theme	free	1036:1039	arg1	radicals					1041:1048	free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid	1036:1137	free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid	1036:1137	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	0	18	theme	selenium	116:123	arg1	nanoparticles					125:137	κ-carrageenan-capped selenium nanoparticles	95:137	κ-carrageenan-capped selenium nanoparticles of different size	95:155	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	1	19	theme	'N	407:408	arg1	2H4-NaOH					409:416	the base-reduction system 'N2H4-NaOH'	381:417	the base-reduction system 'N2H4-NaOH'	381:417	In the present study, water-soluble hybrid selenium-containing nanocomposites have been synthesised via soft oxidation of selenide-anions, preliminarily generated from elemental bulk-selenium in the base-reduction system 'N2H4-NaOH'.
32755962	4	20	theme	luminescence	931:942	arg1	parameters					911:920	the most important parameters	892:920	the most important parameters of their luminescence	892:942	Optical ranges of 'emission/excitation' of aqueous solutions of nanocomposites with Se0NPs of different sizes are established and the most important parameters of their luminescence are determined.
32755962	5	21	dep	2,2'-azino-bis	1084:1097	arg1	acid					1134:1137	3-ethylbenzothiazoline-6-sulphonic acid	1099:1137	2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid	1084:1137	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	4	22	theme	sizes	866:870	arg1	Se0NPs					846:851	Se0NPs	846:851	Se0NPs of different sizes	846:870	Optical ranges of 'emission/excitation' of aqueous solutions of nanocomposites with Se0NPs of different sizes are established and the most important parameters of their luminescence are determined.
32755962	6	23	dep	toxic	1292:1296	arg1	nanocomposites					1269:1282	all obtained nanocomposites	1256:1282	all obtained nanocomposites	1256:1282	It is experimentally revealed that all obtained nanocomposites are low toxic (LD50 >2000 mg/kg).
32755962	6	23	dep	toxic	1292:1296	arg1	>2000 mg/kg					1304:1314	LD50 >2000 mg/kg	1299:1314	LD50 >2000 mg/kg	1299:1314	It is experimentally revealed that all obtained nanocomposites are low toxic (LD50 >2000 mg/kg).
32755962	5	24	theme	which	1168:1172	arg1	value					1159:1163	the value	1155:1163	the value	1155:1163	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	4	25	theme	nanocomposites	826:839	arg1	solutions					813:821	aqueous solutions	805:821	aqueous solutions of nanocomposites with Se0NPs of different sizes	805:870	Optical ranges of 'emission/excitation' of aqueous solutions of nanocomposites with Se0NPs of different sizes are established and the most important parameters of their luminescence are determined.
32755962	7	26	theme	larger	1394:1399	arg1	24.5 nm					1416:1422	24.5 nm	1416:1422	24.5 nm	1416:1422	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	7	26	theme	larger	1394:1399	arg1	nanoparticles					1401:1413	larger nanoparticles	1394:1413	larger nanoparticles (24.5 nm)	1394:1423	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	4	27	theme	Optical	762:768	arg1	ranges					770:775	Optical ranges	762:775	Optical ranges of 'emission/excitation' of aqueous solutions of nanocomposites with Se0NPs of different sizes	762:870	Optical ranges of 'emission/excitation' of aqueous solutions of nanocomposites with Se0NPs of different sizes are established and the most important parameters of their luminescence are determined.
32755962	1	28	theme	soft	290:293	arg1	oxidation					295:303	soft oxidation	290:303	soft oxidation of selenide-anions, preliminarily generated from elemental bulk-selenium in the base-reduction system 'N2H4-NaOH'	290:417	In the present study, water-soluble hybrid selenium-containing nanocomposites have been synthesised via soft oxidation of selenide-anions, preliminarily generated from elemental bulk-selenium in the base-reduction system 'N2H4-NaOH'.
32755962	7	29	from	level	1485:1489	arg1	kidneys					1517:1523	kidneys	1517:1523	kidneys	1517:1523	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	7	29	from	level	1485:1489	arg1	brain					1530:1534	brain	1530:1534	brain	1530:1534	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	7	29	from	level	1485:1489	arg1	liver					1510:1514	the liver	1506:1514	the liver	1506:1514	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	3	30	theme	X-ray	648:652	arg1	methods					639:645	complementary physical-chemical methods	607:645	complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering	607:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	30	theme	X-ray	648:652	arg1	analysis					666:673	X-ray diffraction analysis	648:673	X-ray diffraction analysis	648:673	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	0	31	theme	different	142:150	arg1	size					152:155	different size	142:155	different size	142:155	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	3	32	theme	physical-chemical	621:637	arg1	methods					639:645	complementary physical-chemical methods	607:645	complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering	607:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	32	theme	physical-chemical	621:637	arg1	spectroscopy					718:729	optical spectroscopy	710:729	optical spectroscopy	710:729	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	32	theme	physical-chemical	621:637	arg1	analysis					666:673	X-ray diffraction analysis	648:673	X-ray diffraction analysis	648:673	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	32	theme	physical-chemical	621:637	arg1	scattering					750:759	dynamic light scattering	736:759	dynamic light scattering	736:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	32	theme	physical-chemical	621:637	arg1	microscopy					698:707	transmission electron microscopy	676:707	transmission electron microscopy	676:707	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	5	33	theme	3-ethylbenzothiazoline-6-sulphonic	1099:1132	arg1	acid					1134:1137	3-ethylbenzothiazoline-6-sulphonic acid	1099:1137	2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid	1084:1137	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	0	34	theme	comparative	14:24	arg1	assessment					26:35	comparative assessment	14:35	comparative assessment	14:35	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	5	35	theme	nanoparticles	1206:1218	arg1	size					1189:1192	the size	1185:1192	the size of selenium nanoparticles	1185:1218	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	5	36	theme	antiradical	1007:1017	arg1	activity					1019:1026	the expressed antiradical activity	993:1026	the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid	993:1137	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	1	37	theme	present	193:199	arg1	study					201:205	the present study	189:205	the present study	189:205	In the present study, water-soluble hybrid selenium-containing nanocomposites have been synthesised via soft oxidation of selenide-anions, preliminarily generated from elemental bulk-selenium in the base-reduction system 'N2H4-NaOH'.
32755962	0	38	theme	antiradical	40:50	arg1	activity					52:59	antiradical activity	40:59	antiradical activity	40:59	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	1	39	theme	selenide-anions	308:322	arg1	oxidation					295:303	soft oxidation	290:303	soft oxidation of selenide-anions, preliminarily generated from elemental bulk-selenium in the base-reduction system 'N2H4-NaOH'	290:417	In the present study, water-soluble hybrid selenium-containing nanocomposites have been synthesised via soft oxidation of selenide-anions, preliminarily generated from elemental bulk-selenium in the base-reduction system 'N2H4-NaOH'.
32755962	3	40	theme	dynamic	736:742	arg1	scattering					750:759	dynamic light scattering	736:759	dynamic light scattering	736:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	40	theme	dynamic	736:742	arg1	methods					639:645	complementary physical-chemical methods	607:645	complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering	607:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	2	41	theme	biocompatible	508:520	arg1	polysaccharide					522:535	κ-carrageenan biocompatible polysaccharide	494:535	κ-carrageenan biocompatible polysaccharide	494:535	The nanocomposites obtained consist of Se0NPs (4.6-24.5 nm) stabilised by κ-carrageenan biocompatible polysaccharide.
32755962	0	42	theme	size	152:155	arg1	nanoparticles					125:137	κ-carrageenan-capped selenium nanoparticles	95:137	κ-carrageenan-capped selenium nanoparticles of different size	95:155	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	3	43	theme	transmission	676:687	arg1	microscopy					698:707	transmission electron microscopy	676:707	transmission electron microscopy	676:707	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	43	theme	transmission	676:687	arg1	methods					639:645	complementary physical-chemical methods	607:645	complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering	607:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	2	44	theme	κ-carrageenan	494:506	arg1	polysaccharide					522:535	κ-carrageenan biocompatible polysaccharide	494:535	κ-carrageenan biocompatible polysaccharide	494:535	The nanocomposites obtained consist of Se0NPs (4.6-24.5 nm) stabilised by κ-carrageenan biocompatible polysaccharide.
32755962	5	45	theme	obtained	968:975	arg1	nanocomposites					977:990	the obtained nanocomposites	964:990	the obtained nanocomposites	964:990	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	3	46	theme	diffraction	654:664	arg1	methods					639:645	complementary physical-chemical methods	607:645	complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering	607:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	46	theme	diffraction	654:664	arg1	analysis					666:673	X-ray diffraction analysis	648:673	X-ray diffraction analysis	648:673	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	7	47	theme	lesser	1540:1545	arg1	amounts					1547:1553	lesser amounts	1540:1553	lesser amounts	1540:1553	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	0	48	dep	in	170:171	arg1	vitro					173:177	vitro	173:177	vitro	173:177	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	0	49	theme	activity	52:59	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	0	49	theme	activity	52:59	arg1	assessment					26:35	comparative assessment	14:35	comparative assessment	14:35	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	4	50	with	nanocomposites	826:839	arg1	Se0NPs					846:851	Se0NPs	846:851	Se0NPs of different sizes	846:870	Optical ranges of 'emission/excitation' of aqueous solutions of nanocomposites with Se0NPs of different sizes are established and the most important parameters of their luminescence are determined.
32755962	0	51	theme	in	158:159	arg1	study					179:183	in vivo and in vitro study	158:183	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.	0:184	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	7	52	theme	selenium	1494:1501	arg1	level					1485:1489	the level	1481:1489	the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats	1481:1562	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	7	53	from	liver	1510:1514	arg1	amounts					1547:1553	lesser amounts	1540:1553	lesser amounts	1540:1553	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	0	54	theme	in	170:171	arg1	study					179:183	in vivo and in vitro study	158:183	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.	0:184	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	4	55	theme	important	901:909	arg1	parameters					911:920	the most important parameters	892:920	the most important parameters of their luminescence	892:942	Optical ranges of 'emission/excitation' of aqueous solutions of nanocomposites with Se0NPs of different sizes are established and the most important parameters of their luminescence are determined.
32755962	4	56	theme	solutions	813:821	arg1	emission/excitation					781:799	'emission/excitation'	780:800	'emission/excitation' of aqueous solutions of nanocomposites with Se0NPs of different sizes	780:870	Optical ranges of 'emission/excitation' of aqueous solutions of nanocomposites with Se0NPs of different sizes are established and the most important parameters of their luminescence are determined.
32755962	6	57	theme	obtained	1260:1267	arg1	nanocomposites					1269:1282	all obtained nanocomposites	1256:1282	all obtained nanocomposites	1256:1282	It is experimentally revealed that all obtained nanocomposites are low toxic (LD50 >2000 mg/kg).
32755962	6	57	theme	obtained	1260:1267	arg1	>2000 mg/kg					1304:1314	LD50 >2000 mg/kg	1299:1314	LD50 >2000 mg/kg	1299:1314	It is experimentally revealed that all obtained nanocomposites are low toxic (LD50 >2000 mg/kg).
32755962	1	58	theme	water-soluble	208:220	arg1	nanocomposites					249:262	water-soluble hybrid selenium-containing nanocomposites	208:262	water-soluble hybrid selenium-containing nanocomposites	208:262	In the present study, water-soluble hybrid selenium-containing nanocomposites have been synthesised via soft oxidation of selenide-anions, preliminarily generated from elemental bulk-selenium in the base-reduction system 'N2H4-NaOH'.
32755962	3	59	theme	light	744:748	arg1	scattering					750:759	dynamic light scattering	736:759	dynamic light scattering	736:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	59	theme	light	744:748	arg1	methods					639:645	complementary physical-chemical methods	607:645	complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering	607:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	60	theme	optical	710:716	arg1	methods					639:645	complementary physical-chemical methods	607:645	complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering	607:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	60	theme	optical	710:716	arg1	spectroscopy					718:729	optical spectroscopy	710:729	optical spectroscopy	710:729	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	0	61	dep	in	158:159	arg1	vivo					161:164	vivo	161:164	vivo	161:164	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	7	62	from	kidneys	1517:1523	arg1	amounts					1547:1553	lesser amounts	1540:1553	lesser amounts	1540:1553	It is also found that small selenium nanoparticles (6.8 nm), in contrast to larger nanoparticles (24.5 nm), are accumulated in organisms to significantly increase the level of selenium in the liver, kidneys, and brain (in lesser amounts) of rats.
32755962	1	63	theme	hybrid	222:227	arg1	nanocomposites					249:262	water-soluble hybrid selenium-containing nanocomposites	208:262	water-soluble hybrid selenium-containing nanocomposites	208:262	In the present study, water-soluble hybrid selenium-containing nanocomposites have been synthesised via soft oxidation of selenide-anions, preliminarily generated from elemental bulk-selenium in the base-reduction system 'N2H4-NaOH'.
32755962	5	64	theme	selenium	1197:1204	arg1	nanoparticles					1206:1218	selenium nanoparticles	1197:1218	selenium nanoparticles	1197:1218	For the obtained nanocomposites, the expressed antiradical activity against free radicals 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid has been found, the value of which depends on the size of selenium nanoparticles.
32755962	3	65	theme	electron	689:696	arg1	microscopy					698:707	transmission electron microscopy	676:707	transmission electron microscopy	676:707	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	65	theme	electron	689:696	arg1	methods					639:645	complementary physical-chemical methods	607:645	complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering	607:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	66	theme	nanomaterials	571:583	arg1	structure					542:550	The structure	538:550	The structure of these composite nanomaterials	538:583	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	1	67	theme	selenium-containing	229:247	arg1	nanocomposites					249:262	water-soluble hybrid selenium-containing nanocomposites	208:262	water-soluble hybrid selenium-containing nanocomposites	208:262	In the present study, water-soluble hybrid selenium-containing nanocomposites have been synthesised via soft oxidation of selenide-anions, preliminarily generated from elemental bulk-selenium in the base-reduction system 'N2H4-NaOH'.
32755962	0	68	theme	toxicity	62:69	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	0	68	theme	toxicity	62:69	arg1	assessment					26:35	comparative assessment	14:35	comparative assessment	14:35	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	1	69	theme	elemental	354:362	arg1	bulk-selenium					364:376	elemental bulk-selenium	354:376	elemental bulk-selenium	354:376	In the present study, water-soluble hybrid selenium-containing nanocomposites have been synthesised via soft oxidation of selenide-anions, preliminarily generated from elemental bulk-selenium in the base-reduction system 'N2H4-NaOH'.
32755962	0	70	dep	Synthesis	0:8	arg1	study					179:183	in vivo and in vitro study	158:183	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.	0:184	Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study.
32755962	3	71	dep	methods	639:645	arg1	microscopy					698:707	transmission electron microscopy	676:707	transmission electron microscopy	676:707	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	71	dep	methods	639:645	arg1	spectroscopy					718:729	optical spectroscopy	710:729	optical spectroscopy	710:729	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	71	dep	methods	639:645	arg1	methods					639:645	complementary physical-chemical methods	607:645	complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering	607:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	71	dep	methods	639:645	arg1	analysis					666:673	X-ray diffraction analysis	648:673	X-ray diffraction analysis	648:673	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32755962	3	71	dep	methods	639:645	arg1	scattering					750:759	dynamic light scattering	736:759	dynamic light scattering	736:759	The structure of these composite nanomaterials has been proven using complementary physical-chemical methods: X-ray diffraction analysis, transmission electron microscopy, optical spectroscopy, and dynamic light scattering.
32336373	2	0	with	interaction	366:376	arg1	microorganisms					405:418	other ferment-derived microorganisms	383:418	other ferment-derived microorganisms	383:418	Despite this, little is known about the consequences for the wine-making process associated with the presence and proliferation of this fungus, including its interaction with other ferment-derived microorganisms and impact on the composition of the resulting wine.
32336373	2	1	from	impact	424:429	arg1	composition					438:448	the composition	434:448	the composition of the resulting wine	434:470	Despite this, little is known about the consequences for the wine-making process associated with the presence and proliferation of this fungus, including its interaction with other ferment-derived microorganisms and impact on the composition of the resulting wine.
32336373	3	2	dep	A.	515:516	arg1	pullulans					518:526	pullulans	518:526	pullulans	518:526	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	3	with	polysaccharides	689:703	arg1	glucosidase					781:791	glucosidase	781:791	glucosidase	781:791	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	3	with	polysaccharides	689:703	arg1	activity					805:812	tannase activity	797:812	tannase activity	797:812	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	3	with	polysaccharides	689:703	arg1	β					777:777	β	777:777	β	777:777	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	3	with	polysaccharides	689:703	arg1	pectinase					766:774	pectinase	766:774	pectinase	766:774	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	0	4	from	effects	18:24	arg1	fermentation					84:95	fermentation	84:95	fermentation	84:95	Investigating the effects of Aureobasidium pullulans on grape juice composition and fermentation.
32336373	0	4	from	effects	18:24	arg1	composition					68:78	grape juice composition	56:78	grape juice composition	56:78	Investigating the effects of Aureobasidium pullulans on grape juice composition and fermentation.
32336373	2	5	theme	fungus	344:349	arg1	proliferation					322:334	proliferation	322:334	proliferation	322:334	Despite this, little is known about the consequences for the wine-making process associated with the presence and proliferation of this fungus, including its interaction with other ferment-derived microorganisms and impact on the composition of the resulting wine.
32336373	2	5	theme	fungus	344:349	arg1	presence					309:316	presence	309:316	presence	309:316	Despite this, little is known about the consequences for the wine-making process associated with the presence and proliferation of this fungus, including its interaction with other ferment-derived microorganisms and impact on the composition of the resulting wine.
32336373	3	6	with	enzymes	753:759	arg1	glucosidase					781:791	glucosidase	781:791	glucosidase	781:791	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	6	with	enzymes	753:759	arg1	activity					805:812	tannase activity	797:812	tannase activity	797:812	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	6	with	enzymes	753:759	arg1	β					777:777	β	777:777	β	777:777	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	6	with	enzymes	753:759	arg1	pectinase					766:774	pectinase	766:774	pectinase	766:774	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	7	theme	juice	534:538	arg1	isolates					540:547	abundant A. pullulans grape juice isolates	506:547	abundant A. pullulans grape juice isolates	506:547	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	8	with	polymers	706:713	arg1	glucosidase					781:791	glucosidase	781:791	glucosidase	781:791	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	8	with	polymers	706:713	arg1	activity					805:812	tannase activity	797:812	tannase activity	797:812	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	8	with	polymers	706:713	arg1	β					777:777	β	777:777	β	777:777	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	8	with	polymers	706:713	arg1	pectinase					766:774	pectinase	766:774	pectinase	766:774	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	9	theme	acid	724:727	arg1	enzymes					753:759	enzymes	753:759	enzymes with pectinase, β - glucosidase and tannase activity	753:812	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	9	theme	acid	724:727	arg1	polymers					706:713	polymers	706:713	polymers of malic acid (poly β-malic acid)	706:747	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	9	theme	acid	724:727	arg1	polysaccharides					689:703	polysaccharides	689:703	polysaccharides	689:703	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	10	theme	isolates	540:547	arg1	physiology					492:501	the physiology	488:501	the physiology of abundant A. pullulans grape juice isolates	488:547	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	2	11	theme	wine-making	269:279	arg1	process					281:287	the wine-making process	265:287	the wine-making process associated with the presence and proliferation of this fungus	265:349	Despite this, little is known about the consequences for the wine-making process associated with the presence and proliferation of this fungus, including its interaction with other ferment-derived microorganisms and impact on the composition of the resulting wine.
32336373	3	12	theme	tannase	797:803	arg1	activity					805:812	tannase activity	797:812	tannase activity	797:812	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	4	13	theme	possible	817:824	arg1	effect					839:844	A possible antagonistic effect	815:844	A possible antagonistic effect against yeast through competition for metals including Fe and Zn	815:909	A possible antagonistic effect against yeast through competition for metals including Fe and Zn was also observed.
32336373	1	14	theme	species	168:174	arg1	species					168:174	the most abundant species	150:174	the most abundant species in freshly pressed grape juice	150:205	Aureobasidium pullulans has been observed as one of the most abundant species in freshly pressed grape juice.
32336373	1	14	theme	species	168:174	arg1	one					143:145	one	143:145	one	143:145	Aureobasidium pullulans has been observed as one of the most abundant species in freshly pressed grape juice.
32336373	1	14	theme	species	168:174	arg1	pullulans					112:120	Aureobasidium pullulans	98:120	Aureobasidium pullulans	98:120	Aureobasidium pullulans has been observed as one of the most abundant species in freshly pressed grape juice.
32336373	3	15	theme	grape	528:532	arg1	isolates					540:547	abundant A. pullulans grape juice isolates	506:547	abundant A. pullulans grape juice isolates	506:547	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	2	16	theme	other	383:387	arg1	microorganisms					405:418	other ferment-derived microorganisms	383:418	other ferment-derived microorganisms	383:418	Despite this, little is known about the consequences for the wine-making process associated with the presence and proliferation of this fungus, including its interaction with other ferment-derived microorganisms and impact on the composition of the resulting wine.
32336373	2	17	with	impact	424:429	arg1	microorganisms					405:418	other ferment-derived microorganisms	383:418	other ferment-derived microorganisms	383:418	Despite this, little is known about the consequences for the wine-making process associated with the presence and proliferation of this fungus, including its interaction with other ferment-derived microorganisms and impact on the composition of the resulting wine.
32336373	4	18	theme	antagonistic	826:837	arg1	effect					839:844	A possible antagonistic effect	815:844	A possible antagonistic effect against yeast through competition for metals including Fe and Zn	815:909	A possible antagonistic effect against yeast through competition for metals including Fe and Zn was also observed.
32336373	1	19	theme	Aureobasidium	98:110	arg1	species					168:174	the most abundant species	150:174	the most abundant species in freshly pressed grape juice	150:205	Aureobasidium pullulans has been observed as one of the most abundant species in freshly pressed grape juice.
32336373	1	19	theme	Aureobasidium	98:110	arg1	one					143:145	one	143:145	one	143:145	Aureobasidium pullulans has been observed as one of the most abundant species in freshly pressed grape juice.
32336373	1	19	theme	Aureobasidium	98:110	arg1	pullulans					112:120	Aureobasidium pullulans	98:120	Aureobasidium pullulans	98:120	Aureobasidium pullulans has been observed as one of the most abundant species in freshly pressed grape juice.
32336373	1	20	theme	pressed	187:193	arg1	juice					201:205	freshly pressed grape juice	179:205	freshly pressed grape juice	179:205	Aureobasidium pullulans has been observed as one of the most abundant species in freshly pressed grape juice.
32336373	3	21	theme	malic	718:722	arg1	acid					743:746	poly β-malic acid	730:746	poly β-malic acid	730:746	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	21	theme	malic	718:722	arg1	acid					724:727	malic acid	718:727	malic acid (poly β-malic acid)	718:747	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	5	22	theme	wine	1017:1020	arg1	production					1022:1031	wine production	1017:1031	wine production	1017:1031	Overall, the data suggests this abundant species could have important implications for wine production and quality.
32336373	1	23	theme	grape	195:199	arg1	juice					201:205	freshly pressed grape juice	179:205	freshly pressed grape juice	179:205	Aureobasidium pullulans has been observed as one of the most abundant species in freshly pressed grape juice.
32336373	3	24	theme	lab	574:576	arg1	trials					597:602	lab scale fermentation trials	574:602	lab scale fermentation trials	574:602	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	25	theme	poly	730:733	arg1	acid					743:746	poly β-malic acid	730:746	poly β-malic acid	730:746	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	25	theme	poly	730:733	arg1	acid					724:727	malic acid	718:727	malic acid (poly β-malic acid)	718:747	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	1	26	theme	abundant	159:166	arg1	species					168:174	the most abundant species	150:174	the most abundant species in freshly pressed grape juice	150:205	Aureobasidium pullulans has been observed as one of the most abundant species in freshly pressed grape juice.
32336373	0	27	theme	pullulans	43:51	arg1	effects					18:24	the effects	14:24	the effects of Aureobasidium pullulans on grape juice composition and fermentation	14:95	Investigating the effects of Aureobasidium pullulans on grape juice composition and fermentation.
32336373	3	28	theme	β-malic	735:741	arg1	acid					743:746	poly β-malic acid	730:746	poly β-malic acid	730:746	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	28	theme	β-malic	735:741	arg1	acid					724:727	malic acid	718:727	malic acid (poly β-malic acid)	718:747	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	5	29	theme	important	990:998	arg1	implications					1000:1011	important implications	990:1011	important implications for wine production and quality	990:1043	Overall, the data suggests this abundant species could have important implications for wine production and quality.
32336373	2	30	theme	ferment-derived	389:403	arg1	microorganisms					405:418	other ferment-derived microorganisms	383:418	other ferment-derived microorganisms	383:418	Despite this, little is known about the consequences for the wine-making process associated with the presence and proliferation of this fungus, including its interaction with other ferment-derived microorganisms and impact on the composition of the resulting wine.
32336373	0	31	theme	Aureobasidium	29:41	arg1	pullulans					43:51	Aureobasidium pullulans	29:51	Aureobasidium pullulans	29:51	Investigating the effects of Aureobasidium pullulans on grape juice composition and fermentation.
32336373	2	32	link	ferment-derived	389:403	arg1	microorganisms					405:418	other ferment-derived microorganisms	383:418	other ferment-derived microorganisms	383:418	Despite this, little is known about the consequences for the wine-making process associated with the presence and proliferation of this fungus, including its interaction with other ferment-derived microorganisms and impact on the composition of the resulting wine.
32336373	2	33	theme	wine	467:470	arg1	composition					438:448	the composition	434:448	the composition of the resulting wine	434:470	Despite this, little is known about the consequences for the wine-making process associated with the presence and proliferation of this fungus, including its interaction with other ferment-derived microorganisms and impact on the composition of the resulting wine.
32336373	0	34	theme	juice	62:66	arg1	composition					68:78	grape juice composition	56:78	grape juice composition	56:78	Investigating the effects of Aureobasidium pullulans on grape juice composition and fermentation.
32336373	3	35	theme	scale	578:582	arg1	trials					597:602	lab scale fermentation trials	574:602	lab scale fermentation trials	574:602	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	2	36	from	interaction	366:376	arg1	composition					438:448	the composition	434:448	the composition of the resulting wine	434:470	Despite this, little is known about the consequences for the wine-making process associated with the presence and proliferation of this fungus, including its interaction with other ferment-derived microorganisms and impact on the composition of the resulting wine.
32336373	2	37	theme	resulting	457:465	arg1	wine					467:470	the resulting wine	453:470	the resulting wine	453:470	Despite this, little is known about the consequences for the wine-making process associated with the presence and proliferation of this fungus, including its interaction with other ferment-derived microorganisms and impact on the composition of the resulting wine.
32336373	3	38	theme	species	639:645	arg1	ability					623:629	the ability	619:629	the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity	619:812	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	39	theme	fermentation	584:595	arg1	trials					597:602	lab scale fermentation trials	574:602	lab scale fermentation trials	574:602	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	5	40	theme	abundant	962:969	arg1	species					971:977	this abundant species	957:977	this abundant species	957:977	Overall, the data suggests this abundant species could have important implications for wine production and quality.
32336373	2	41	dep	presence	309:316	arg1	the					305:307	the	305:307	the	305:307	Despite this, little is known about the consequences for the wine-making process associated with the presence and proliferation of this fungus, including its interaction with other ferment-derived microorganisms and impact on the composition of the resulting wine.
32336373	3	42	theme	grape	661:665	arg1	juice					667:671	grape juice	661:671	grape juice	661:671	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	3	43	theme	abundant	506:513	arg1	isolates					540:547	abundant A. pullulans grape juice isolates	506:547	abundant A. pullulans grape juice isolates	506:547	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	0	44	theme	grape	56:60	arg1	composition					68:78	grape juice composition	56:78	grape juice composition	56:78	Investigating the effects of Aureobasidium pullulans on grape juice composition and fermentation.
32336373	1	45	from	species	168:174	arg1	juice					201:205	freshly pressed grape juice	179:205	freshly pressed grape juice	179:205	Aureobasidium pullulans has been observed as one of the most abundant species in freshly pressed grape juice.
32336373	3	46	theme	A.	515:516	arg1	isolates					540:547	abundant A. pullulans grape juice isolates	506:547	abundant A. pullulans grape juice isolates	506:547	In this study, the physiology of abundant A. pullulans grape juice isolates was investigated through lab scale fermentation trials, demonstrating the ability of this species to survive in grape juice while producing polysaccharides, polymers of malic acid (poly β-malic acid) and enzymes with pectinase, β - glucosidase and tannase activity.
32336373	5	47	contain	have	985:988	arg2	implications					1000:1011	important implications	990:1011	important implications for wine production and quality	990:1043	Overall, the data suggests this abundant species could have important implications for wine production and quality.
32336373	5	47	contain	have	985:988	arg1	species					971:977	this abundant species	957:977	this abundant species	957:977	Overall, the data suggests this abundant species could have important implications for wine production and quality.
33964528	0	0	theme	hydrogel	84:91	arg1	interfaces					106:115	dual stimuli-responsive composite hydrogel nanoparticle interfaces	50:115	dual stimuli-responsive composite hydrogel nanoparticle interfaces	50:115	Design, fabrication and drug release potential of dual stimuli-responsive composite hydrogel nanoparticle interfaces.
33964528	4	1	theme	controlled	906:915	arg1	release					922:928	dual (pH and thermo)-responsive controlled drug release	874:928	dual (pH and thermo)-responsive controlled drug release	874:928	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	8	2	theme	drug	1342:1345	arg1	delivery					1347:1354	temperature-triggered drug delivery	1320:1354	temperature-triggered drug delivery	1320:1354	Thus, all the results together unveil that CNPs would thrive as a promising pH and temperature-triggered drug delivery platform for the GI tract and colon targeted drug delivery.
33964528	4	3	theme	several	615:621	arg1	morphology					681:690	spherical morphology	671:690	spherical morphology	671:690	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	3	theme	several	615:621	arg1	particle					704:711	uniform particle	696:711	uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release	696:928	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	3	theme	several	615:621	arg1	properties					649:658	several conducive physicochemical properties	615:658	several conducive physicochemical properties	615:658	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	0	4	theme	composite	74:82	arg1	interfaces					106:115	dual stimuli-responsive composite hydrogel nanoparticle interfaces	50:115	dual stimuli-responsive composite hydrogel nanoparticle interfaces	50:115	Design, fabrication and drug release potential of dual stimuli-responsive composite hydrogel nanoparticle interfaces.
33964528	4	5	theme	-responsive	894:904	arg1	release					922:928	dual (pH and thermo)-responsive controlled drug release	874:928	dual (pH and thermo)-responsive controlled drug release	874:928	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	6	theme	drug	917:920	arg1	release					922:928	dual (pH and thermo)-responsive controlled drug release	874:928	dual (pH and thermo)-responsive controlled drug release	874:928	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	7	from	CNPs	753:756	arg1	release					740:746	distribution.In vitro drug release	713:746	distribution.In vitro drug release from CNPs	713:756	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	6	8	theme	drug	1010:1013	arg1	results					1023:1029	The drug release results	1006:1029	The drug release results	1006:1029	The drug release results disclose that the structure of CNPs was disassembled at 55 °C to release the encapsulated drug molecules in a controlled fashion.
33964528	0	9	theme	interfaces	106:115	arg1	fabrication					8:18	fabrication	8:18	fabrication	8:18	Design, fabrication and drug release potential of dual stimuli-responsive composite hydrogel nanoparticle interfaces.
33964528	0	9	theme	interfaces	106:115	arg1	Design					0:5	Design	0:5	Design	0:5	Design, fabrication and drug release potential of dual stimuli-responsive composite hydrogel nanoparticle interfaces.
33964528	0	9	theme	interfaces	106:115	arg1	potential					37:45	drug release potential	24:45	drug release potential	24:45	Design, fabrication and drug release potential of dual stimuli-responsive composite hydrogel nanoparticle interfaces.
33964528	4	10	theme	temperature	834:844	arg1	range					846:850	a temperature range	832:850	a temperature range of 37-55 °C	832:862	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	11	theme	environment	817:827	arg1	pHs					782:784	different pHs	772:784	different pHs of gastrointestinal (GI) tract environment	772:827	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	12	theme	GI	807:808	arg1	tract					811:815	gastrointestinal (GI) tract	789:815	gastrointestinal (GI) tract environment	789:827	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	13	theme	physicochemical	633:647	arg1	morphology					681:690	spherical morphology	671:690	spherical morphology	671:690	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	13	theme	physicochemical	633:647	arg1	particle					704:711	uniform particle	696:711	uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release	696:928	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	13	theme	physicochemical	633:647	arg1	properties					649:658	several conducive physicochemical properties	615:658	several conducive physicochemical properties	615:658	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	0	14	theme	nanoparticle	93:104	arg1	interfaces					106:115	dual stimuli-responsive composite hydrogel nanoparticle interfaces	50:115	dual stimuli-responsive composite hydrogel nanoparticle interfaces	50:115	Design, fabrication and drug release potential of dual stimuli-responsive composite hydrogel nanoparticle interfaces.
33964528	4	15	theme	tract	811:815	arg1	environment					817:827	gastrointestinal (GI) tract environment	789:827	gastrointestinal (GI) tract environment	789:827	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	1	16	from	attention	170:178	arg1	nanomedicine					202:213	nanomedicine	202:213	nanomedicine	202:213	Nanocomposite hydrogel particles grasp considerable attention in nanotechnology and nanomedicine as one of the potential drug delivery platforms.
33964528	1	16	from	attention	170:178	arg1	nanotechnology					183:196	nanotechnology	183:196	nanotechnology	183:196	Nanocomposite hydrogel particles grasp considerable attention in nanotechnology and nanomedicine as one of the potential drug delivery platforms.
33964528	3	17	theme	ionic	577:581	arg1	strategy					592:599	an ionic gelation strategy	574:599	an ionic gelation strategy	574:599	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	3	18	theme	nanocomposite	508:520	arg1	CNPs					546:549	CNPs	546:549	CNPs	546:549	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	3	18	theme	nanocomposite	508:520	arg1	nanoparticles					531:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles	382:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs)	382:550	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	3	19	theme	hydrogel	522:529	arg1	CNPs					546:549	CNPs	546:549	CNPs	546:549	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	3	19	theme	hydrogel	522:529	arg1	nanoparticles					531:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles	382:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs)	382:550	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	6	20	theme	CNPs	1062:1065	arg1	structure					1049:1057	the structure	1045:1057	the structure of CNPs	1045:1065	The drug release results disclose that the structure of CNPs was disassembled at 55 °C to release the encapsulated drug molecules in a controlled fashion.
33964528	8	21	theme	delivery	1347:1354	arg1	platform					1356:1363	a promising pH and temperature-triggered drug delivery platform	1301:1363	a promising pH and temperature-triggered drug delivery platform for the GI tract and colon targeted drug delivery	1301:1413	Thus, all the results together unveil that CNPs would thrive as a promising pH and temperature-triggered drug delivery platform for the GI tract and colon targeted drug delivery.
33964528	3	22	theme	poly	382:385	arg1	CNPs					546:549	CNPs	546:549	CNPs	546:549	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	3	22	theme	poly	382:385	arg1	nanoparticles					531:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles	382:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs)	382:550	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	3	23	theme	-carbon	422:428	arg1	CNPs					546:549	CNPs	546:549	CNPs	546:549	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	3	23	theme	-carbon	422:428	arg1	nanoparticles					531:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles	382:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs)	382:550	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	7	24	theme	human	1213:1217	arg1	cells					1230:1234	human fibroblast cells	1213:1234	human fibroblast cells	1213:1234	The CNPs also displayed good cell viability against human fibroblast cells.
33964528	2	25	theme	delivery	296:303	arg1	strategy					305:312	a coveted drug delivery strategy	281:312	prevail a coveted drug delivery strategy with sustain and stimuli-drug release	273:350	However, prevail a coveted drug delivery strategy with sustain and stimuli-drug release is still challenging.
33964528	2	26	dep	prevail	273:279	arg1	strategy					305:312	a coveted drug delivery strategy	281:312	prevail a coveted drug delivery strategy with sustain and stimuli-drug release	273:350	However, prevail a coveted drug delivery strategy with sustain and stimuli-drug release is still challenging.
33964528	7	27	theme	good	1185:1188	arg1	viability					1195:1203	good cell viability	1185:1203	good cell viability	1185:1203	The CNPs also displayed good cell viability against human fibroblast cells.
33964528	4	28	theme	distribution.In	713:727	arg1	release					740:746	distribution.In vitro drug release	713:746	distribution.In vitro drug release from CNPs	713:756	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	5	29	theme	highest	964:970	arg1	release					977:983	the highest drug release	960:983	the highest drug release	960:983	Under pH 7.4, CNPs exhibited the highest drug release at 55 °C in 15 days.
33964528	8	30	dep	tract	1376:1380	arg1	delivery					1406:1413	targeted drug delivery	1392:1413	targeted drug delivery	1392:1413	Thus, all the results together unveil that CNPs would thrive as a promising pH and temperature-triggered drug delivery platform for the GI tract and colon targeted drug delivery.
33964528	7	31	theme	cell	1190:1193	arg1	viability					1195:1203	good cell viability	1185:1203	good cell viability	1185:1203	The CNPs also displayed good cell viability against human fibroblast cells.
33964528	4	32	theme	gastrointestinal	789:804	arg1	tract					811:815	gastrointestinal (GI) tract	789:815	gastrointestinal (GI) tract environment	789:827	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	6	33	theme	release	1015:1021	arg1	results					1023:1029	The drug release results	1006:1029	The drug release results	1006:1029	The drug release results disclose that the structure of CNPs was disassembled at 55 °C to release the encapsulated drug molecules in a controlled fashion.
33964528	3	34	theme	PAPMA-CNOs = f-CNOs	443:461	arg1	CNPs					546:549	CNPs	546:549	CNPs	546:549	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	3	34	theme	PAPMA-CNOs = f-CNOs	443:461	arg1	nanoparticles					531:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles	382:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs)	382:550	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	2	35	theme	stimuli-drug	331:342	arg1	release					344:350	stimuli-drug release	331:350	stimuli-drug release	331:350	However, prevail a coveted drug delivery strategy with sustain and stimuli-drug release is still challenging.
33964528	8	36	theme	drug	1401:1404	arg1	delivery					1406:1413	targeted drug delivery	1392:1413	targeted drug delivery	1392:1413	Thus, all the results together unveil that CNPs would thrive as a promising pH and temperature-triggered drug delivery platform for the GI tract and colon targeted drug delivery.
33964528	3	37	theme	4-aminophenyl	391:403	arg1	poly					382:385	poly	382:385	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs)	382:550	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	3	37	theme	4-aminophenyl	391:403	arg1	methacrylamide					406:419	N-(4-aminophenyl) methacrylamide	388:419	N-(4-aminophenyl) methacrylamide	388:419	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	5	38	theme	drug	972:975	arg1	release					977:983	the highest drug release	960:983	the highest drug release	960:983	Under pH 7.4, CNPs exhibited the highest drug release at 55 °C in 15 days.
33964528	1	39	theme	Nanocomposite	118:130	arg1	particles					141:149	Nanocomposite hydrogel particles	118:149	Nanocomposite hydrogel particles	118:149	Nanocomposite hydrogel particles grasp considerable attention in nanotechnology and nanomedicine as one of the potential drug delivery platforms.
33964528	1	40	theme	potential	229:237	arg1	drug					239:242	the potential drug delivery platforms	225:261	the potential drug delivery platforms	225:261	Nanocomposite hydrogel particles grasp considerable attention in nanotechnology and nanomedicine as one of the potential drug delivery platforms.
33964528	0	41	theme	release	29:35	arg1	potential					37:45	drug release potential	24:45	drug release potential	24:45	Design, fabrication and drug release potential of dual stimuli-responsive composite hydrogel nanoparticle interfaces.
33964528	8	42	theme	temperature-triggered	1320:1340	arg1	delivery					1347:1354	temperature-triggered drug delivery	1320:1354	temperature-triggered drug delivery	1320:1354	Thus, all the results together unveil that CNPs would thrive as a promising pH and temperature-triggered drug delivery platform for the GI tract and colon targeted drug delivery.
33964528	3	43	theme	integrated	483:492	arg1	CNPs					546:549	CNPs	546:549	CNPs	546:549	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	3	43	theme	integrated	483:492	arg1	nanoparticles					531:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles	382:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs)	382:550	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	4	44	dep	particle	704:711	arg1	found					868:872	found	868:872	found dual (pH and thermo)-responsive controlled drug release	868:928	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	44	dep	particle	704:711	arg1	vetted					762:767	vetted	762:767	vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C	762:862	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	45	theme	drug	735:738	arg1	release					740:746	distribution.In vitro drug release	713:746	distribution.In vitro drug release from CNPs	713:756	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	1	46	theme	drug	239:242	arg1	one					218:220	one	218:220	one	218:220	Nanocomposite hydrogel particles grasp considerable attention in nanotechnology and nanomedicine as one of the potential drug delivery platforms.
33964528	1	46	theme	drug	239:242	arg1	drug					239:242	the potential drug delivery platforms	225:261	the potential drug delivery platforms	225:261	Nanocomposite hydrogel particles grasp considerable attention in nanotechnology and nanomedicine as one of the potential drug delivery platforms.
33964528	0	47	theme	drug	24:27	arg1	potential					37:45	drug release potential	24:45	drug release potential	24:45	Design, fabrication and drug release potential of dual stimuli-responsive composite hydrogel nanoparticle interfaces.
33964528	3	48	theme	nano-onions	430:440	arg1	CNPs					546:549	CNPs	546:549	CNPs	546:549	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	3	48	theme	nano-onions	430:440	arg1	nanoparticles					531:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles	382:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs)	382:550	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	8	49	theme	pH	1313:1314	arg1	platform					1356:1363	a promising pH and temperature-triggered drug delivery platform	1301:1363	a promising pH and temperature-triggered drug delivery platform for the GI tract and colon targeted drug delivery	1301:1413	Thus, all the results together unveil that CNPs would thrive as a promising pH and temperature-triggered drug delivery platform for the GI tract and colon targeted drug delivery.
33964528	4	50	theme	spherical	671:679	arg1	morphology					681:690	spherical morphology	671:690	spherical morphology	671:690	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	1	51	theme	delivery	244:251	arg1	platforms					253:261	delivery platforms	244:261	the potential drug delivery platforms	225:261	Nanocomposite hydrogel particles grasp considerable attention in nanotechnology and nanomedicine as one of the potential drug delivery platforms.
33964528	2	52	with	prevail	273:279	arg1	sustain					319:325	sustain	319:325	sustain	319:325	However, prevail a coveted drug delivery strategy with sustain and stimuli-drug release is still challenging.
33964528	2	52	with	prevail	273:279	arg1	release					344:350	stimuli-drug release	331:350	stimuli-drug release	331:350	However, prevail a coveted drug delivery strategy with sustain and stimuli-drug release is still challenging.
33964528	4	53	contain	possess	607:613	arg2	morphology					681:690	spherical morphology	671:690	spherical morphology	671:690	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	53	contain	possess	607:613	arg2	particle					704:711	uniform particle	696:711	uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release	696:928	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	53	contain	possess	607:613	arg2	properties					649:658	several conducive physicochemical properties	615:658	several conducive physicochemical properties	615:658	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	53	contain	possess	607:613	arg1	CNPs					602:605	CNPs	602:605	CNPs	602:605	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	8	54	theme	GI	1373:1374	arg1	tract					1376:1380	the GI tract	1369:1380	the GI tract	1369:1380	Thus, all the results together unveil that CNPs would thrive as a promising pH and temperature-triggered drug delivery platform for the GI tract and colon targeted drug delivery.
33964528	1	55	theme	hydrogel	132:139	arg1	particles					141:149	Nanocomposite hydrogel particles	118:149	Nanocomposite hydrogel particles	118:149	Nanocomposite hydrogel particles grasp considerable attention in nanotechnology and nanomedicine as one of the potential drug delivery platforms.
33964528	4	56	dep	-responsive	894:904	arg1	thermo					887:892	thermo	887:892	thermo	887:892	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	56	dep	-responsive	894:904	arg1	pH					880:881	pH	880:881	pH	880:881	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	57	theme	dual	874:877	arg1	release					922:928	dual (pH and thermo)-responsive controlled drug release	874:928	dual (pH and thermo)-responsive controlled drug release	874:928	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	7	58	theme	fibroblast	1219:1228	arg1	cells					1230:1234	human fibroblast cells	1213:1234	human fibroblast cells	1213:1234	The CNPs also displayed good cell viability against human fibroblast cells.
33964528	4	59	theme	different	772:780	arg1	pHs					782:784	different pHs	772:784	different pHs of gastrointestinal (GI) tract environment	772:827	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	2	60	theme	drug	291:294	arg1	strategy					305:312	a coveted drug delivery strategy	281:312	prevail a coveted drug delivery strategy with sustain and stimuli-drug release	273:350	However, prevail a coveted drug delivery strategy with sustain and stimuli-drug release is still challenging.
33964528	1	61	dep	drug	239:242	arg1	platforms					253:261	delivery platforms	244:261	the potential drug delivery platforms	225:261	Nanocomposite hydrogel particles grasp considerable attention in nanotechnology and nanomedicine as one of the potential drug delivery platforms.
33964528	8	62	theme	targeted	1392:1399	arg1	delivery					1406:1413	targeted drug delivery	1392:1413	targeted drug delivery	1392:1413	Thus, all the results together unveil that CNPs would thrive as a promising pH and temperature-triggered drug delivery platform for the GI tract and colon targeted drug delivery.
33964528	8	63	theme	promising	1303:1311	arg1	pH					1313:1314	promising pH	1303:1314	promising pH	1303:1314	Thus, all the results together unveil that CNPs would thrive as a promising pH and temperature-triggered drug delivery platform for the GI tract and colon targeted drug delivery.
33964528	3	64	theme	gelation	583:590	arg1	strategy					592:599	an ionic gelation strategy	574:599	an ionic gelation strategy	574:599	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	2	65	theme	coveted	283:289	arg1	strategy					305:312	a coveted drug delivery strategy	281:312	prevail a coveted drug delivery strategy with sustain and stimuli-drug release	273:350	However, prevail a coveted drug delivery strategy with sustain and stimuli-drug release is still challenging.
33964528	1	66	theme	considerable	157:168	arg1	attention					170:178	considerable attention	157:178	considerable attention in nanotechnology and nanomedicine	157:213	Nanocomposite hydrogel particles grasp considerable attention in nanotechnology and nanomedicine as one of the potential drug delivery platforms.
33964528	6	67	theme	controlled	1141:1150	arg1	fashion					1152:1158	a controlled fashion	1139:1158	a controlled fashion	1139:1158	The drug release results disclose that the structure of CNPs was disassembled at 55 °C to release the encapsulated drug molecules in a controlled fashion.
33964528	0	68	theme	stimuli-responsive	55:72	arg1	interfaces					106:115	dual stimuli-responsive composite hydrogel nanoparticle interfaces	50:115	dual stimuli-responsive composite hydrogel nanoparticle interfaces	50:115	Design, fabrication and drug release potential of dual stimuli-responsive composite hydrogel nanoparticle interfaces.
33964528	4	69	theme	uniform	696:702	arg1	particle					704:711	uniform particle	696:711	uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release	696:928	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	70	theme	37-55 °C	855:862	arg1	range					846:850	a temperature range	832:850	a temperature range of 37-55 °C	832:862	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	6	71	theme	drug	1121:1124	arg1	molecules					1126:1134	the encapsulated drug molecules	1104:1134	the encapsulated drug molecules	1104:1134	The drug release results disclose that the structure of CNPs was disassembled at 55 °C to release the encapsulated drug molecules in a controlled fashion.
33964528	3	72	theme	/diclofenac-complex	463:481	arg1	CNPs					546:549	CNPs	546:549	CNPs	546:549	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	3	72	theme	/diclofenac-complex	463:481	arg1	nanoparticles					531:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles	382:543	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs)	382:550	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	4	73	theme	conducive	623:631	arg1	morphology					681:690	spherical morphology	671:690	spherical morphology	671:690	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	73	theme	conducive	623:631	arg1	particle					704:711	uniform particle	696:711	uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release	696:928	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	4	73	theme	conducive	623:631	arg1	properties					649:658	several conducive physicochemical properties	615:658	several conducive physicochemical properties	615:658	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	0	74	theme	dual	50:53	arg1	interfaces					106:115	dual stimuli-responsive composite hydrogel nanoparticle interfaces	50:115	dual stimuli-responsive composite hydrogel nanoparticle interfaces	50:115	Design, fabrication and drug release potential of dual stimuli-responsive composite hydrogel nanoparticle interfaces.
33964528	4	75	dep	distribution.In	713:727	arg1	vitro					729:733	vitro	729:733	vitro	729:733	CNPs possess several conducive physicochemical properties, including spherical morphology and uniform particle distribution.In vitro drug release from CNPs was vetted in different pHs of gastrointestinal (GI) tract environment at a temperature range of 37-55 °C and found dual (pH and thermo)-responsive controlled drug release.
33964528	6	76	theme	encapsulated	1108:1119	arg1	molecules					1126:1134	the encapsulated drug molecules	1104:1134	the encapsulated drug molecules	1104:1134	The drug release results disclose that the structure of CNPs was disassembled at 55 °C to release the encapsulated drug molecules in a controlled fashion.
33964528	3	77	theme	N-	388:389	arg1	poly					382:385	poly	382:385	poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs)	382:550	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33964528	3	77	theme	N-	388:389	arg1	methacrylamide					406:419	N-(4-aminophenyl) methacrylamide	388:419	N-(4-aminophenyl) methacrylamide	388:419	Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs)/diclofenac-complex integrated chitosan (CS) nanocomposite hydrogel nanoparticles (CNPs) were fabricated using an ionic gelation strategy.
33783190	7	0	theme	novel	1148:1152	arg1	treatments					1154:1163	novel treatments	1148:1163	novel treatments for fibrotic diseases	1148:1185	This versatile hydrogel can be used for in vitro studies of fibrosis of different tissues, thus enabling the development of novel treatments for fibrotic diseases.
33783190	1	1	theme	collagen	168:175	arg1	deposition					154:163	excessive deposition	144:163	excessive deposition of collagen and increased tissue stiffness	144:206	Fibrosis is a pathological condition that leads to excessive deposition of collagen and increased tissue stiffness.
33783190	2	2	theme	matrix	523:528	arg1	structure					457:465	filamentous structure	445:465	filamentous structure	445:465	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	2	2	theme	matrix	523:528	arg1	properties					482:491	mechanical properties	471:491	mechanical properties	471:491	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	7	3	theme	treatments	1154:1163	arg1	development					1133:1143	the development	1129:1143	the development of novel treatments for fibrotic diseases	1129:1185	This versatile hydrogel can be used for in vitro studies of fibrosis of different tissues, thus enabling the development of novel treatments for fibrotic diseases.
33783190	7	4	dep	in	1064:1065	arg1	vitro					1067:1071	vitro	1067:1071	vitro	1067:1071	This versatile hydrogel can be used for in vitro studies of fibrosis of different tissues, thus enabling the development of novel treatments for fibrotic diseases.
33783190	6	5	theme	biocompatible	922:934	arg1	hydrogel					936:943	this biocompatible hydrogel	917:943	this biocompatible hydrogel	917:943	We demonstrate that this biocompatible hydrogel supports the three-dimensional culture of cells relevant to fibrotic diseases.
33783190	3	6	theme	nanofibrillar	555:567	arg1	hydrogel					569:576	a nanofibrillar hydrogel	553:576	a nanofibrillar hydrogel	553:576	Here, we report a nanofibrillar hydrogel composed of cellulose nanocrystals and gelatin, which addresses this challenge.
33783190	2	7	used	used	405:408	arg2	hydrogels					376:384	hydrogels	376:384	hydrogels that are currently used for this purpose	376:425	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	2	8	theme	models	312:317	arg1	development					278:288	the development	274:288	the development of effective in vitro models that recapitulate its properties and structure	274:364	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	2	9	dep	in	303:304	arg1	vitro					306:310	vitro	306:310	vitro	306:310	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	1	10	theme	increased	181:189	arg1	stiffness					198:206	increased tissue stiffness	181:206	increased tissue stiffness	181:206	Fibrosis is a pathological condition that leads to excessive deposition of collagen and increased tissue stiffness.
33783190	2	11	dep	structure	457:465	arg1	the					441:443	the	441:443	the	441:443	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	0	12	theme	Nanofibrillar	0:12	arg1	Hydrogel					14:21	Nanofibrillar Hydrogel	0:21	Nanofibrillar Hydrogel	0:21	Nanofibrillar Hydrogel Recapitulates Changes Occurring in the Fibrotic Extracellular Matrix.
33783190	1	13	theme	tissue	191:196	arg1	stiffness					198:206	increased tissue stiffness	181:206	increased tissue stiffness	181:206	Fibrosis is a pathological condition that leads to excessive deposition of collagen and increased tissue stiffness.
33783190	5	14	from	variations	825:834	arg1	properties					859:868	properties	859:868	properties	859:868	Furthermore, we decoupled the variations in hydrogel structure, properties, and ligand concentration.
33783190	5	14	from	variations	825:834	arg1	structure					848:856	hydrogel structure	839:856	hydrogel structure	839:856	Furthermore, we decoupled the variations in hydrogel structure, properties, and ligand concentration.
33783190	5	14	from	variations	825:834	arg1	concentration					882:894	ligand concentration	875:894	ligand concentration	875:894	Furthermore, we decoupled the variations in hydrogel structure, properties, and ligand concentration.
33783190	3	15	theme	cellulose	590:598	arg1	nanocrystals					600:611	cellulose nanocrystals	590:611	cellulose nanocrystals	590:611	Here, we report a nanofibrillar hydrogel composed of cellulose nanocrystals and gelatin, which addresses this challenge.
33783190	1	16	theme	stiffness	198:206	arg1	deposition					154:163	excessive deposition	144:163	excessive deposition of collagen and increased tissue stiffness	144:206	Fibrosis is a pathological condition that leads to excessive deposition of collagen and increased tissue stiffness.
33783190	2	17	theme	mechanical	471:480	arg1	properties					482:491	mechanical properties	471:491	mechanical properties	471:491	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	4	18	theme	fibrotic	781:788	arg1	ECM					790:792	fibrotic ECM	781:792	fibrotic ECM	781:792	By altering the composition of the hydrogel, we mimicked the changes in structure, mechanical properties, and chemistry of fibrotic ECM.
33783190	4	19	theme	hydrogel	693:700	arg1	composition					674:684	the composition	670:684	the composition of the hydrogel	670:700	By altering the composition of the hydrogel, we mimicked the changes in structure, mechanical properties, and chemistry of fibrotic ECM.
33783190	6	20	theme	fibrotic	1005:1012	arg1	diseases					1014:1021	fibrotic diseases	1005:1021	fibrotic diseases	1005:1021	We demonstrate that this biocompatible hydrogel supports the three-dimensional culture of cells relevant to fibrotic diseases.
33783190	7	21	theme	different	1096:1104	arg1	tissues					1106:1112	different tissues	1096:1112	different tissues	1096:1112	This versatile hydrogel can be used for in vitro studies of fibrosis of different tissues, thus enabling the development of novel treatments for fibrotic diseases.
33783190	1	22	theme	pathological	107:118	arg1	Fibrosis					93:100	Fibrosis	93:100	Fibrosis	93:100	Fibrosis is a pathological condition that leads to excessive deposition of collagen and increased tissue stiffness.
33783190	1	22	theme	pathological	107:118	arg1	condition					120:128	a pathological condition	105:128	a pathological condition that leads to excessive deposition of collagen and increased tissue stiffness	105:206	Fibrosis is a pathological condition that leads to excessive deposition of collagen and increased tissue stiffness.
33783190	2	23	theme	filamentous	445:455	arg1	structure					457:465	filamentous structure	445:465	filamentous structure	445:465	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	5	24	theme	hydrogel	839:846	arg1	structure					848:856	hydrogel structure	839:856	hydrogel structure	839:856	Furthermore, we decoupled the variations in hydrogel structure, properties, and ligand concentration.
33783190	7	25	theme	tissues	1106:1112	arg1	fibrosis					1084:1091	fibrosis	1084:1091	fibrosis of different tissues	1084:1112	This versatile hydrogel can be used for in vitro studies of fibrosis of different tissues, thus enabling the development of novel treatments for fibrotic diseases.
33783190	2	26	theme	extracellular	509:521	arg1	ECM					531:533	ECM	531:533	ECM	531:533	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	2	26	theme	extracellular	509:521	arg1	matrix					523:528	the fibrotic extracellular matrix	496:528	the fibrotic extracellular matrix (ECM)	496:534	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	6	27	theme	relevant	993:1000	arg1	cells					987:991	cells	987:991	cells relevant to fibrotic diseases	987:1021	We demonstrate that this biocompatible hydrogel supports the three-dimensional culture of cells relevant to fibrotic diseases.
33783190	7	28	theme	fibrosis	1084:1091	arg1	studies					1073:1079	in vitro studies	1064:1079	in vitro studies of fibrosis of different tissues	1064:1112	This versatile hydrogel can be used for in vitro studies of fibrosis of different tissues, thus enabling the development of novel treatments for fibrotic diseases.
33783190	7	29	used	used	1055:1058	arg2	hydrogel					1039:1046	This versatile hydrogel	1024:1046	This versatile hydrogel	1024:1046	This versatile hydrogel can be used for in vitro studies of fibrosis of different tissues, thus enabling the development of novel treatments for fibrotic diseases.
33783190	2	30	theme	fibrotic	500:507	arg1	ECM					531:533	ECM	531:533	ECM	531:533	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	2	30	theme	fibrotic	500:507	arg1	matrix					523:528	the fibrotic extracellular matrix	496:528	the fibrotic extracellular matrix (ECM)	496:534	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	6	31	theme	cells	987:991	arg1	culture					976:982	the three-dimensional culture	954:982	the three-dimensional culture of cells relevant to fibrotic diseases	954:1021	We demonstrate that this biocompatible hydrogel supports the three-dimensional culture of cells relevant to fibrotic diseases.
33783190	0	32	theme	Fibrotic	62:69	arg1	Matrix					85:90	the Fibrotic Extracellular Matrix	58:90	the Fibrotic Extracellular Matrix	58:90	Nanofibrillar Hydrogel Recapitulates Changes Occurring in the Fibrotic Extracellular Matrix.
33783190	2	33	theme	tissue	254:259	arg1	mechanobiology					227:240	the mechanobiology	223:240	the mechanobiology of fibrotic tissue	223:259	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	7	34	theme	fibrotic	1169:1176	arg1	diseases					1178:1185	fibrotic diseases	1169:1185	fibrotic diseases	1169:1185	This versatile hydrogel can be used for in vitro studies of fibrosis of different tissues, thus enabling the development of novel treatments for fibrotic diseases.
33783190	2	35	theme	fibrotic	245:252	arg1	tissue					254:259	fibrotic tissue	245:259	fibrotic tissue	245:259	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	6	36	theme	three-dimensional	958:974	arg1	culture					976:982	the three-dimensional culture	954:982	the three-dimensional culture of cells relevant to fibrotic diseases	954:1021	We demonstrate that this biocompatible hydrogel supports the three-dimensional culture of cells relevant to fibrotic diseases.
33783190	7	37	theme	in	1064:1065	arg1	studies					1073:1079	in vitro studies	1064:1079	in vitro studies of fibrosis of different tissues	1064:1112	This versatile hydrogel can be used for in vitro studies of fibrosis of different tissues, thus enabling the development of novel treatments for fibrotic diseases.
33783190	2	38	theme	in	303:304	arg1	models					312:317	effective in vitro models	293:317	effective in vitro models that recapitulate its properties and structure	293:364	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	4	39	theme	mechanical	741:750	arg1	properties					752:761	mechanical properties	741:761	mechanical properties	741:761	By altering the composition of the hydrogel, we mimicked the changes in structure, mechanical properties, and chemistry of fibrotic ECM.
33783190	4	40	theme	ECM	790:792	arg1	structure					730:738	structure	730:738	structure	730:738	By altering the composition of the hydrogel, we mimicked the changes in structure, mechanical properties, and chemistry of fibrotic ECM.
33783190	4	40	theme	ECM	790:792	arg1	properties					752:761	mechanical properties	741:761	mechanical properties	741:761	By altering the composition of the hydrogel, we mimicked the changes in structure, mechanical properties, and chemistry of fibrotic ECM.
33783190	4	40	theme	ECM	790:792	arg1	chemistry					768:776	chemistry	768:776	chemistry	768:776	By altering the composition of the hydrogel, we mimicked the changes in structure, mechanical properties, and chemistry of fibrotic ECM.
33783190	2	41	theme	effective	293:301	arg1	models					312:317	effective in vitro models	293:317	effective in vitro models that recapitulate its properties and structure	293:364	Understanding the mechanobiology of fibrotic tissue necessitates the development of effective in vitro models that recapitulate its properties and structure; however, hydrogels that are currently used for this purpose fail to mimic the filamentous structure and mechanical properties of the fibrotic extracellular matrix (ECM).
33783190	7	42	theme	versatile	1029:1037	arg1	hydrogel					1039:1046	This versatile hydrogel	1024:1046	This versatile hydrogel	1024:1046	This versatile hydrogel can be used for in vitro studies of fibrosis of different tissues, thus enabling the development of novel treatments for fibrotic diseases.
33783190	1	43	theme	excessive	144:152	arg1	deposition					154:163	excessive deposition	144:163	excessive deposition of collagen and increased tissue stiffness	144:206	Fibrosis is a pathological condition that leads to excessive deposition of collagen and increased tissue stiffness.
33783190	5	44	theme	ligand	875:880	arg1	concentration					882:894	ligand concentration	875:894	ligand concentration	875:894	Furthermore, we decoupled the variations in hydrogel structure, properties, and ligand concentration.
33783190	0	45	theme	Extracellular	71:83	arg1	Matrix					85:90	the Fibrotic Extracellular Matrix	58:90	the Fibrotic Extracellular Matrix	58:90	Nanofibrillar Hydrogel Recapitulates Changes Occurring in the Fibrotic Extracellular Matrix.
33783190	4	46	from	changes	719:725	arg1	structure					730:738	structure	730:738	structure	730:738	By altering the composition of the hydrogel, we mimicked the changes in structure, mechanical properties, and chemistry of fibrotic ECM.
33783190	4	46	from	changes	719:725	arg1	properties					752:761	mechanical properties	741:761	mechanical properties	741:761	By altering the composition of the hydrogel, we mimicked the changes in structure, mechanical properties, and chemistry of fibrotic ECM.
33783190	4	46	from	changes	719:725	arg1	chemistry					768:776	chemistry	768:776	chemistry	768:776	By altering the composition of the hydrogel, we mimicked the changes in structure, mechanical properties, and chemistry of fibrotic ECM.
33255014	0	0	theme	drug	94:97	arg1	release					99:105	delayed and extended drug release	73:105	delayed and extended drug release	73:105	Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents.
33255014	6	1	theme	size	1165:1168	arg1	particles					1143:1151	particles	1143:1151	particles of suitable size for multiparticulate systems	1143:1197	In addition, particles of suitable size for multiparticulate systems were obtained and with higher thermal stability when compared to the pure drug.
33255014	6	2	theme	higher	1222:1227	arg1	stability					1237:1245	higher thermal stability	1222:1245	higher thermal stability	1222:1245	In addition, particles of suitable size for multiparticulate systems were obtained and with higher thermal stability when compared to the pure drug.
33255014	0	3	theme	extended	85:92	arg1	release					99:105	delayed and extended drug release	73:105	delayed and extended drug release	73:105	Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents.
33255014	3	4	theme	loading	666:672	arg1	capacity					674:681	drug loading capacity	661:681	drug loading capacity (>20%)	661:688	Comparing the formulations with and without crosslinking agent, the best results were obtained for that composed only of sericin and alginate, with satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%).
33255014	3	4	theme	loading	666:672	arg1	%					687:687	>20%	684:687	>20%	684:687	Comparing the formulations with and without crosslinking agent, the best results were obtained for that composed only of sericin and alginate, with satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%).
33255014	1	5	theme	dibasic	274:280	arg1	phosphate					289:297	dibasic sodium phosphate	274:297	the covalent crosslinking agents dibasic sodium phosphate	241:297	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	4	6	theme	acid	730:733	arg1	medium					735:740	acid medium	730:740	acid medium	730:740	In this case, delayed release (<10% in acid medium) and prolonged release (~360 min) were achieved, with a complex release mechanism involving swelling and polymer chain relaxation.
33255014	1	7	theme	sodium	282:287	arg1	phosphate					289:297	dibasic sodium phosphate	274:297	the covalent crosslinking agents dibasic sodium phosphate	241:297	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	5	8	theme	Fourier	1027:1033	arg1	characterization					943:958	characterization	943:958	characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix	943:1127	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	4	9	dep	release	713:719	arg1	%					725:725	<10%	722:725	<10% in acid medium	722:740	In this case, delayed release (<10% in acid medium) and prolonged release (~360 min) were achieved, with a complex release mechanism involving swelling and polymer chain relaxation.
33255014	0	10	theme	covalent	123:130	arg1	agents					145:150	different covalent crosslinking agents	113:150	different covalent crosslinking agents	113:150	Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents.
33255014	3	11	theme	crosslinking	501:512	arg1	agent					514:518	crosslinking agent	501:518	crosslinking agent	501:518	Comparing the formulations with and without crosslinking agent, the best results were obtained for that composed only of sericin and alginate, with satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%).
33255014	0	12	theme	different	113:121	arg1	agents					145:150	different covalent crosslinking agents	113:150	different covalent crosslinking agents	113:150	Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents.
33255014	6	13	theme	multiparticulate	1174:1189	arg1	systems					1191:1197	multiparticulate systems	1174:1197	multiparticulate systems	1174:1197	In addition, particles of suitable size for multiparticulate systems were obtained and with higher thermal stability when compared to the pure drug.
33255014	4	14	from	%	725:725	arg1	medium					735:740	acid medium	730:740	acid medium	730:740	In this case, delayed release (<10% in acid medium) and prolonged release (~360 min) were achieved, with a complex release mechanism involving swelling and polymer chain relaxation.
33255014	4	15	theme	complex	798:804	arg1	mechanism					814:822	a complex release mechanism	796:822	a complex release mechanism involving swelling and polymer chain relaxation	796:870	In this case, delayed release (<10% in acid medium) and prolonged release (~360 min) were achieved, with a complex release mechanism involving swelling and polymer chain relaxation.
33255014	5	16	theme	microscopy	1006:1015	arg1	characterization					943:958	characterization	943:958	characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix	943:1127	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	5	17	with	compatibility	1091:1103	arg1	matrix					1122:1127	the polymer matrix	1110:1127	the polymer matrix	1110:1127	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	5	18	theme	drug	898:901	arg1	incorporation					877:889	The incorporation	873:889	The incorporation of the drug	873:901	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	1	19	theme	alginate	212:219	arg1	blend					221:225	alginate blend	212:225	alginate blend	212:225	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	1	20	theme	polyvinyl	300:308	arg1	alcohol					310:316	polyvinyl alcohol	300:316	polyvinyl alcohol	300:316	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	1	20	theme	polyvinyl	300:308	arg1	agents					267:272	the covalent crosslinking agents dibasic sodium phosphate	241:297	the covalent crosslinking agents dibasic sodium phosphate	241:297	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	6	21	theme	pure	1268:1271	arg1	drug					1273:1276	the pure drug	1264:1276	the pure drug	1264:1276	In addition, particles of suitable size for multiparticulate systems were obtained and with higher thermal stability when compared to the pure drug.
33255014	4	22	theme	release	806:812	arg1	mechanism					814:822	a complex release mechanism	796:822	a complex release mechanism involving swelling and polymer chain relaxation	796:870	In this case, delayed release (<10% in acid medium) and prolonged release (~360 min) were achieved, with a complex release mechanism involving swelling and polymer chain relaxation.
33255014	5	23	dep	transform	1035:1043	arg1	infrared					1045:1052	infrared	1045:1052	transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix	1035:1127	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	0	24	theme	crosslinking	132:143	arg1	agents					145:150	different covalent crosslinking agents	113:150	different covalent crosslinking agents	113:150	Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents.
33255014	2	25	theme	incorporation	431:443	arg1	efficiency					445:454	incorporation efficiency	431:454	incorporation efficiency	431:454	Sericin has been shown to be essential for improving incorporation efficiency.
33255014	0	26	theme	sericin/alginate	46:61	arg1	beads					63:67	naproxen-loaded sericin/alginate beads	30:67	naproxen-loaded sericin/alginate beads	30:67	Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents.
33255014	5	27	theme	polymer	1114:1120	arg1	matrix					1122:1127	the polymer matrix	1110:1127	the polymer matrix	1110:1127	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	3	28	theme	drug	661:664	arg1	capacity					674:681	drug loading capacity	661:681	drug loading capacity (>20%)	661:688	Comparing the formulations with and without crosslinking agent, the best results were obtained for that composed only of sericin and alginate, with satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%).
33255014	3	28	theme	drug	661:664	arg1	%					687:687	>20%	684:687	>20%	684:687	Comparing the formulations with and without crosslinking agent, the best results were obtained for that composed only of sericin and alginate, with satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%).
33255014	5	29	theme	diffraction	969:979	arg1	characterization					943:958	characterization	943:958	characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix	943:1127	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	6	30	theme	suitable	1156:1163	arg1	size					1165:1168	suitable size	1156:1168	suitable size for multiparticulate systems	1156:1197	In addition, particles of suitable size for multiparticulate systems were obtained and with higher thermal stability when compared to the pure drug.
33255014	0	31	theme	naproxen-loaded	30:44	arg1	beads					63:67	naproxen-loaded sericin/alginate beads	30:67	naproxen-loaded sericin/alginate beads	30:67	Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents.
33255014	1	32	theme	polyethylene	322:333	arg1	glycol					335:340	polyethylene glycol	322:340	polyethylene glycol	322:340	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	1	32	theme	polyethylene	322:333	arg1	agents					267:272	the covalent crosslinking agents dibasic sodium phosphate	241:297	the covalent crosslinking agents dibasic sodium phosphate	241:297	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	5	33	theme	drug	1086:1089	arg1	compatibility					1091:1103	drug compatibility	1086:1103	drug compatibility with the polymer matrix	1086:1127	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	4	34	theme	polymer	847:853	arg1	relaxation					861:870	polymer chain relaxation	847:870	polymer chain relaxation	847:870	In this case, delayed release (<10% in acid medium) and prolonged release (~360 min) were achieved, with a complex release mechanism involving swelling and polymer chain relaxation.
33255014	0	35	theme	beads	63:67	arg1	evaluation					16:25	evaluation	16:25	evaluation	16:25	Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents.
33255014	0	35	theme	beads	63:67	arg1	Development					0:10	Development	0:10	Development	0:10	Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents.
33255014	5	36	dep	Fourier	1027:1033	arg1	transform					1035:1043	transform	1035:1043	transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix	1035:1127	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	3	37	theme	satisfactory	605:616	arg1	values					618:623	satisfactory values	605:623	satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%)	605:688	Comparing the formulations with and without crosslinking agent, the best results were obtained for that composed only of sericin and alginate, with satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%).
33255014	3	38	theme	best	525:528	arg1	results					530:536	the best results	521:536	the best results	521:536	Comparing the formulations with and without crosslinking agent, the best results were obtained for that composed only of sericin and alginate, with satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%).
33255014	5	39	theme	X-ray	963:967	arg1	XRD					982:984	XRD	982:984	XRD	982:984	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	5	39	theme	X-ray	963:967	arg1	diffraction					969:979	X-ray diffraction	963:979	X-ray diffraction (XRD)	963:985	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	6	40	theme	thermal	1229:1235	arg1	stability					1237:1245	higher thermal stability	1222:1245	higher thermal stability	1222:1245	In addition, particles of suitable size for multiparticulate systems were obtained and with higher thermal stability when compared to the pure drug.
33255014	5	41	theme	scanning	988:995	arg1	SEM					1018:1020	SEM	1018:1020	SEM	1018:1020	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	5	41	theme	scanning	988:995	arg1	microscopy					1006:1015	scanning electron microscopy	988:1015	scanning electron microscopy (SEM)	988:1021	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	4	42	theme	prolonged	747:755	arg1	release					757:763	prolonged release	747:763	prolonged release (~360 min)	747:774	In this case, delayed release (<10% in acid medium) and prolonged release (~360 min) were achieved, with a complex release mechanism involving swelling and polymer chain relaxation.
33255014	4	42	theme	prolonged	747:755	arg1	~360 min					766:773	~360 min	766:773	~360 min	766:773	In this case, delayed release (<10% in acid medium) and prolonged release (~360 min) were achieved, with a complex release mechanism involving swelling and polymer chain relaxation.
33255014	4	43	theme	delayed	705:711	arg1	release					713:719	delayed release	705:719	delayed release (<10% in acid medium)	705:741	In this case, delayed release (<10% in acid medium) and prolonged release (~360 min) were achieved, with a complex release mechanism involving swelling and polymer chain relaxation.
33255014	5	44	with	spectroscopy	1054:1065	arg1	matrix					1122:1127	the polymer matrix	1110:1127	the polymer matrix	1110:1127	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	4	45	theme	chain	855:859	arg1	relaxation					861:870	polymer chain relaxation	847:870	polymer chain relaxation	847:870	In this case, delayed release (<10% in acid medium) and prolonged release (~360 min) were achieved, with a complex release mechanism involving swelling and polymer chain relaxation.
33255014	1	46	dep	agents	267:272	arg1	alcohol					310:316	polyvinyl alcohol	300:316	polyvinyl alcohol	300:316	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	1	46	dep	agents	267:272	arg1	glycol					335:340	polyethylene glycol	322:340	polyethylene glycol	322:340	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	1	46	dep	agents	267:272	arg1	agents					267:272	the covalent crosslinking agents dibasic sodium phosphate	241:297	the covalent crosslinking agents dibasic sodium phosphate	241:297	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	1	46	dep	agents	267:272	arg1	phosphate					289:297	dibasic sodium phosphate	274:297	the covalent crosslinking agents dibasic sodium phosphate	241:297	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	5	47	theme	characterization	943:958	arg1	techniques					929:938	the techniques	925:938	the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix	925:1127	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	1	48	theme	Different	153:161	arg1	compositions					178:189	Different polymer matrix compositions	153:189	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol)	153:341	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	5	49	theme	electron	997:1004	arg1	SEM					1018:1020	SEM	1018:1020	SEM	1018:1020	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	5	49	theme	electron	997:1004	arg1	microscopy					1006:1015	scanning electron microscopy	988:1015	scanning electron microscopy (SEM)	988:1021	The incorporation of the drug could be confirmed by the techniques of characterization of X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), as well as drug compatibility with the polymer matrix.
33255014	3	50	theme	capacity	674:681	arg1	values					618:623	satisfactory values	605:623	satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%)	605:688	Comparing the formulations with and without crosslinking agent, the best results were obtained for that composed only of sericin and alginate, with satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%).
33255014	3	51	theme	entrapment	628:637	arg1	efficiency					639:648	entrapment efficiency	628:648	entrapment efficiency (>80%)	628:655	Comparing the formulations with and without crosslinking agent, the best results were obtained for that composed only of sericin and alginate, with satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%).
33255014	3	51	theme	entrapment	628:637	arg1	%					654:654	>80%	651:654	>80%	651:654	Comparing the formulations with and without crosslinking agent, the best results were obtained for that composed only of sericin and alginate, with satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%).
33255014	1	52	theme	polymer	163:169	arg1	compositions					178:189	Different polymer matrix compositions	153:189	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol)	153:341	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	1	53	theme	covalent	245:252	arg1	alcohol					310:316	polyvinyl alcohol	300:316	polyvinyl alcohol	300:316	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	1	53	theme	covalent	245:252	arg1	glycol					335:340	polyethylene glycol	322:340	polyethylene glycol	322:340	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	1	53	theme	covalent	245:252	arg1	agents					267:272	the covalent crosslinking agents dibasic sodium phosphate	241:297	the covalent crosslinking agents dibasic sodium phosphate	241:297	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	0	54	theme	delayed	73:79	arg1	release					99:105	delayed and extended drug release	73:105	delayed and extended drug release	73:105	Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents.
33255014	3	55	theme	efficiency	639:648	arg1	values					618:623	satisfactory values	605:623	satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%)	605:688	Comparing the formulations with and without crosslinking agent, the best results were obtained for that composed only of sericin and alginate, with satisfactory values of entrapment efficiency (>80%) and drug loading capacity (>20%).
33255014	1	56	theme	matrix	171:176	arg1	compositions					178:189	Different polymer matrix compositions	153:189	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol)	153:341	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	1	57	theme	crosslinking	254:265	arg1	alcohol					310:316	polyvinyl alcohol	300:316	polyvinyl alcohol	300:316	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	1	57	theme	crosslinking	254:265	arg1	glycol					335:340	polyethylene glycol	322:340	polyethylene glycol	322:340	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33255014	1	57	theme	crosslinking	254:265	arg1	agents					267:272	the covalent crosslinking agents dibasic sodium phosphate	241:297	the covalent crosslinking agents dibasic sodium phosphate	241:297	Different polymer matrix compositions based on sericin and alginate blend (using or not the covalent crosslinking agents dibasic sodium phosphate, polyvinyl alcohol and polyethylene glycol) were evaluated to entrap naproxen.
33030887	0	0	theme	Pressure	99:106	arg1	Detection					86:94	Highly Sensitive Detection	69:94	Highly Sensitive Detection of Pressure and Proximity	69:120	Silver Nanowire-Bacterial Cellulose Composite Fiber-Based Sensor for Highly Sensitive Detection of Pressure and Proximity.
33030887	10	1	theme	objects	1635:1641	arg1	detection					1615:1623	two- and three-dimensional location detection	1579:1623	two- and three-dimensional location detection of remote objects	1579:1641	A 2 × 2 array was further shown for two- and three-dimensional location detection of remote objects.
33030887	6	2	from	increase	1034:1041	arg1	kPa					1079:1081	0 to 460 kPa	1070:1081	0 to 460 kPa	1070:1081	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	6	2	from	increase	1034:1041	arg1	range					1059:1063	the pressure range	1046:1063	the pressure range from 0 to 460 kPa	1046:1081	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	2	3	theme	human	390:394	arg1	fingers					396:402	human fingers	390:402	human fingers	390:402	We report a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers.
33030887	10	4	theme	remote	1628:1633	arg1	objects					1635:1641	remote objects	1628:1641	remote objects	1628:1641	A 2 × 2 array was further shown for two- and three-dimensional location detection of remote objects.
33030887	3	5	from	μm	516:517	arg1	break					631:635	break	631:635	break	631:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	6	6	theme	monotonic	1012:1020	arg1	increase					1034:1041	monotonic capacitance increase	1012:1041	monotonic capacitance increase in the pressure range from 0 to 460 kPa	1012:1081	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	6	7	with	response	1097:1104	arg1	sensitivity					1118:1128	a high sensitivity	1111:1128	a high sensitivity of 5.49 kPa-1	1111:1142	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	0	8	theme	Proximity	112:120	arg1	Detection					86:94	Highly Sensitive Detection	69:94	Highly Sensitive Detection of Pressure and Proximity	69:120	Silver Nanowire-Bacterial Cellulose Composite Fiber-Based Sensor for Highly Sensitive Detection of Pressure and Proximity.
33030887	2	9	theme	cellulose	295:303	arg1	fiber					305:309	a hierarchically porous silver nanowire-bacterial cellulose fiber	245:309	a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers	245:402	We report a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers.
33030887	10	10	theme	location	1606:1613	arg1	detection					1615:1623	two- and three-dimensional location detection	1579:1623	two- and three-dimensional location detection of remote objects	1579:1641	A 2 × 2 array was further shown for two- and three-dimensional location detection of remote objects.
33030887	3	11	theme	1.3	551:553	arg1	×					555:555	×	555:555	×	555:555	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	2	12	used	utilized	323:330	arg2	fiber					305:309	a hierarchically porous silver nanowire-bacterial cellulose fiber	245:309	a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers	245:402	We report a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers.
33030887	6	13	theme	kPa-1	1138:1142	arg1	sensitivity					1118:1128	a high sensitivity	1111:1128	a high sensitivity of 5.49 kPa-1	1111:1142	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	4	14	theme	poly	690:693	arg1	elastomer					724:732	a 10 μm thick poly(dimethylsiloxane) dielectric elastomer	676:732	a 10 μm thick poly(dimethylsiloxane) dielectric elastomer	676:732	The fibers were coaxially coated with a 10 μm thick poly(dimethylsiloxane) dielectric elastomer to form the fiber sensor element which is thinner than a human hair.
33030887	9	15	theme	sensor	1425:1430	arg1	able					1441:1444	able	1441:1444	able	1441:1444	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	9	15	theme	sensor	1425:1430	arg1	array					1432:1436	A fiber sensor array	1417:1436	A fiber sensor array	1417:1436	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	9	15	theme	sensor	1425:1430	arg1	piano					1470:1474	a touchless piano	1458:1474	a touchless piano	1458:1474	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	9	15	theme	sensor	1425:1430	arg1	proximity					1519:1527	the proximity	1515:1527	the proximity of an object	1515:1540	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	6	16	theme	low-pressure	1164:1175	arg1	regime					1177:1182	the low-pressure regime	1160:1182	the low-pressure regime (<0.5 kPa)	1160:1193	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	6	16	theme	low-pressure	1164:1175	arg1	kPa					1190:1192	<0.5 kPa	1185:1192	<0.5 kPa	1185:1192	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	3	17	theme	μm	516:517	arg1	diameter					501:508	a diameter	499:508	a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break	499:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	7	18	dep	30	1280:1281	arg1	to					1277:1278	to	1277:1278	to	1277:1278	In touchless mode, the sensor is highly sensitive to objects at a distance of up to 30 cm.
33030887	6	19	theme	capacitance	1022:1032	arg1	increase					1034:1041	monotonic capacitance increase	1012:1041	monotonic capacitance increase in the pressure range from 0 to 460 kPa	1012:1081	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	3	20	theme	conductivity	535:546	arg1	diameter					501:508	a diameter	499:508	a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break	499:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	7	21	theme	touchless	1199:1207	arg1	mode					1209:1212	touchless mode	1199:1212	touchless mode	1199:1212	In touchless mode, the sensor is highly sensitive to objects at a distance of up to 30 cm.
33030887	4	22	theme	sensor	752:757	arg1	element					759:765	the fiber sensor element	742:765	the fiber sensor element which is thinner than a human hair	742:800	The fibers were coaxially coated with a 10 μm thick poly(dimethylsiloxane) dielectric elastomer to form the fiber sensor element which is thinner than a human hair.
33030887	4	22	theme	sensor	752:757	arg1	thinner					776:782	thinner	776:782	thinner	776:782	The fibers were coaxially coated with a 10 μm thick poly(dimethylsiloxane) dielectric elastomer to form the fiber sensor element which is thinner than a human hair.
33030887	5	23	theme	capacitance	858:868	arg1	changes					870:876	the capacitance changes	854:876	the capacitance changes between the conductive cores	854:905	Two of the sensor fibers were laid diagonally, and the capacitance changes between the conductive cores were measured in response to pressure and proximity.
33030887	8	24	theme	vocal	1403:1407	arg1	pulses					1409:1414	vocal pulses	1403:1414	vocal pulses	1403:1414	Also, the fiber can be easily stitched into garments as comfortable and fashionable sensors to detect heartbeat and vocal pulses.
33030887	10	25	theme	two-	1579:1582	arg1	detection					1615:1623	two- and three-dimensional location detection	1579:1623	two- and three-dimensional location detection of remote objects	1579:1641	A 2 × 2 array was further shown for two- and three-dimensional location detection of remote objects.
33030887	1	26	dep	immersive	171:179	arg1	experience					181:190	experience	181:190	experience	181:190	Fiber-based sensors are desirable to provide an immersive experience for users in the human-computer interface.
33030887	7	27	from	sensitive	1236:1244	arg1	mode					1209:1212	touchless mode	1199:1212	touchless mode	1199:1212	In touchless mode, the sensor is highly sensitive to objects at a distance of up to 30 cm.
33030887	6	28	theme	fiber-based	981:991	arg1	sensor					993:998	a fiber-based sensor	979:998	a fiber-based sensor	979:998	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	3	29	theme	S/cm	561:564	arg1	strain					613:618	elongation strain	602:618	elongation strain of 3.0% at break	602:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	29	theme	S/cm	561:564	arg1	conductivity					535:546	the electrical conductivity	520:546	the electrical conductivity of 1.3 × 104 S/cm	520:564	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	29	theme	S/cm	561:564	arg1	μm					516:517	53 μm	513:517	53 μm	513:517	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	29	theme	S/cm	561:564	arg1	strength					577:584	a tensile strength	567:584	a tensile strength of 198 MPa	567:595	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	4	30	theme	human	791:795	arg1	hair					797:800	a human hair	789:800	a human hair	789:800	The fibers were coaxially coated with a 10 μm thick poly(dimethylsiloxane) dielectric elastomer to form the fiber sensor element which is thinner than a human hair.
33030887	4	31	theme	thick	684:688	arg1	dimethylsiloxane					695:710	dimethylsiloxane	695:710	dimethylsiloxane	695:710	The fibers were coaxially coated with a 10 μm thick poly(dimethylsiloxane) dielectric elastomer to form the fiber sensor element which is thinner than a human hair.
33030887	4	31	theme	thick	684:688	arg1	poly					690:693	thick poly	684:693	a 10 μm thick poly(dimethylsiloxane) dielectric elastomer	676:732	The fibers were coaxially coated with a 10 μm thick poly(dimethylsiloxane) dielectric elastomer to form the fiber sensor element which is thinner than a human hair.
33030887	4	32	theme	dielectric	713:722	arg1	elastomer					724:732	a 10 μm thick poly(dimethylsiloxane) dielectric elastomer	676:732	a 10 μm thick poly(dimethylsiloxane) dielectric elastomer	676:732	The fibers were coaxially coated with a 10 μm thick poly(dimethylsiloxane) dielectric elastomer to form the fiber sensor element which is thinner than a human hair.
33030887	6	33	dep	460	1075:1077	arg1	to					1072:1073	to	1072:1073	to	1072:1073	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	0	34	theme	Composite	36:44	arg1	Sensor					58:63	Cellulose Composite Fiber-Based Sensor	26:63	Cellulose Composite Fiber-Based Sensor for Highly Sensitive Detection of Pressure and Proximity	26:120	Silver Nanowire-Bacterial Cellulose Composite Fiber-Based Sensor for Highly Sensitive Detection of Pressure and Proximity.
33030887	3	35	theme	MPa	593:595	arg1	strain					613:618	elongation strain	602:618	elongation strain of 3.0% at break	602:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	35	theme	MPa	593:595	arg1	conductivity					535:546	the electrical conductivity	520:546	the electrical conductivity of 1.3 × 104 S/cm	520:564	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	35	theme	MPa	593:595	arg1	μm					516:517	53 μm	513:517	53 μm	513:517	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	35	theme	MPa	593:595	arg1	strength					577:584	a tensile strength	567:584	a tensile strength of 198 MPa	567:595	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	10	36	theme	three-dimensional	1588:1604	arg1	detection					1615:1623	two- and three-dimensional location detection	1579:1623	two- and three-dimensional location detection of remote objects	1579:1641	A 2 × 2 array was further shown for two- and three-dimensional location detection of remote objects.
33030887	3	37	theme	104	557:559	arg1	×					555:555	×	555:555	×	555:555	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	38	from	strength	577:584	arg1	break					631:635	break	631:635	break	631:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	1	39	theme	human-computer	209:222	arg1	interface					224:232	the human-computer interface	205:232	the human-computer interface	205:232	Fiber-based sensors are desirable to provide an immersive experience for users in the human-computer interface.
33030887	0	40	theme	Cellulose	26:34	arg1	Sensor					58:63	Cellulose Composite Fiber-Based Sensor	26:63	Cellulose Composite Fiber-Based Sensor for Highly Sensitive Detection of Pressure and Proximity	26:120	Silver Nanowire-Bacterial Cellulose Composite Fiber-Based Sensor for Highly Sensitive Detection of Pressure and Proximity.
33030887	8	41	theme	fashionable	1359:1369	arg1	sensors					1371:1377	comfortable and fashionable sensors	1343:1377	comfortable and fashionable sensors	1343:1377	Also, the fiber can be easily stitched into garments as comfortable and fashionable sensors to detect heartbeat and vocal pulses.
33030887	10	42	theme	×	1547:1547	arg1	array					1551:1555	A 2 × 2 array	1543:1555	A 2 × 2 array	1543:1555	A 2 × 2 array was further shown for two- and three-dimensional location detection of remote objects.
33030887	6	43	theme	linear	1090:1095	arg1	response					1097:1104	a linear response	1088:1104	a linear response with a high sensitivity of 5.49 kPa-1	1088:1142	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	1	44	theme	Fiber-based	123:133	arg1	sensors					135:141	Fiber-based sensors	123:141	Fiber-based sensors	123:141	Fiber-based sensors are desirable to provide an immersive experience for users in the human-computer interface.
33030887	6	45	from	kPa	1079:1081	arg1	increase					1034:1041	monotonic capacitance increase	1012:1041	monotonic capacitance increase in the pressure range from 0 to 460 kPa	1012:1081	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	6	45	from	kPa	1079:1081	arg1	range					1059:1063	the pressure range	1046:1063	the pressure range from 0 to 460 kPa	1046:1081	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	3	46	theme	conductive	409:418	arg1	fiber					420:424	The conductive fiber	405:424	The conductive fiber	405:424	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	47	theme	continuous	446:455	arg1	wet-spinning					457:468	continuous wet-spinning	446:468	continuous wet-spinning at a speed of 20 m/min	446:491	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	5	48	theme	conductive	890:899	arg1	cores					901:905	the conductive cores	886:905	the conductive cores	886:905	Two of the sensor fibers were laid diagonally, and the capacitance changes between the conductive cores were measured in response to pressure and proximity.
33030887	9	49	theme	fiber	1419:1423	arg1	able					1441:1444	able	1441:1444	able	1441:1444	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	9	49	theme	fiber	1419:1423	arg1	array					1432:1436	A fiber sensor array	1417:1436	A fiber sensor array	1417:1436	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	9	49	theme	fiber	1419:1423	arg1	piano					1470:1474	a touchless piano	1458:1474	a touchless piano	1458:1474	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	9	49	theme	fiber	1419:1423	arg1	proximity					1519:1527	the proximity	1515:1527	the proximity of an object	1515:1540	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	3	50	theme	%	626:626	arg1	strain					613:618	elongation strain	602:618	elongation strain of 3.0% at break	602:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	50	theme	%	626:626	arg1	conductivity					535:546	the electrical conductivity	520:546	the electrical conductivity of 1.3 × 104 S/cm	520:564	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	50	theme	%	626:626	arg1	μm					516:517	53 μm	513:517	53 μm	513:517	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	50	theme	%	626:626	arg1	strength					577:584	a tensile strength	567:584	a tensile strength of 198 MPa	567:595	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	2	51	theme	porous	262:267	arg1	fiber					305:309	a hierarchically porous silver nanowire-bacterial cellulose fiber	245:309	a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers	245:402	We report a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers.
33030887	6	52	theme	touch	967:971	arg1	mode					973:976	the touch mode	963:976	the touch mode	963:976	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	0	53	theme	Fiber-Based	46:56	arg1	Sensor					58:63	Cellulose Composite Fiber-Based Sensor	26:63	Cellulose Composite Fiber-Based Sensor for Highly Sensitive Detection of Pressure and Proximity	26:120	Silver Nanowire-Bacterial Cellulose Composite Fiber-Based Sensor for Highly Sensitive Detection of Pressure and Proximity.
33030887	9	54	theme	object	1535:1540	arg1	array					1432:1436	A fiber sensor array	1417:1436	A fiber sensor array	1417:1436	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	9	54	theme	object	1535:1540	arg1	proximity					1519:1527	the proximity	1515:1527	the proximity of an object	1515:1540	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	9	54	theme	object	1535:1540	arg1	piano					1470:1474	a touchless piano	1458:1474	a touchless piano	1458:1474	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	3	55	theme	strain	613:618	arg1	diameter					501:508	a diameter	499:508	a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break	499:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	6	56	theme	5.49	1133:1136	arg1	kPa-1					1138:1142	5.49 kPa-1	1133:1142	5.49 kPa-1	1133:1142	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	3	57	theme	m/min	487:491	arg1	speed					475:479	a speed	473:479	a speed of 20 m/min	473:491	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	58	from	strain	613:618	arg1	break					631:635	break	631:635	break	631:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	59	from	break	631:635	arg1	strain					613:618	elongation strain	602:618	elongation strain of 3.0% at break	602:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	59	from	break	631:635	arg1	%					626:626	3.0%	623:626	3.0% at break	623:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	59	from	break	631:635	arg1	conductivity					535:546	the electrical conductivity	520:546	the electrical conductivity of 1.3 × 104 S/cm	520:564	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	59	from	break	631:635	arg1	μm					516:517	53 μm	513:517	53 μm	513:517	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	59	from	break	631:635	arg1	strength					577:584	a tensile strength	567:584	a tensile strength of 198 MPa	567:595	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	60	theme	tensile	569:575	arg1	strength					577:584	a tensile strength	567:584	a tensile strength of 198 MPa	567:595	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	6	61	theme	pressure	1050:1057	arg1	range					1059:1063	the pressure range	1046:1063	the pressure range from 0 to 460 kPa	1046:1081	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	2	62	theme	proximity	377:385	arg1	detection					346:354	sensitive detection	336:354	sensitive detection of both pressure and proximity of human fingers	336:402	We report a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers.
33030887	8	63	theme	comfortable	1343:1353	arg1	sensors					1371:1377	comfortable and fashionable sensors	1343:1377	comfortable and fashionable sensors	1343:1377	Also, the fiber can be easily stitched into garments as comfortable and fashionable sensors to detect heartbeat and vocal pulses.
33030887	3	64	theme	strength	577:584	arg1	diameter					501:508	a diameter	499:508	a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break	499:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	7	65	from	distance	1262:1269	arg1	sensor					1219:1224	the sensor	1215:1224	the sensor	1215:1224	In touchless mode, the sensor is highly sensitive to objects at a distance of up to 30 cm.
33030887	7	65	from	distance	1262:1269	arg1	sensitive					1236:1244	sensitive	1236:1244	sensitive	1236:1244	In touchless mode, the sensor is highly sensitive to objects at a distance of up to 30 cm.
33030887	4	66	theme	fiber	746:750	arg1	element					759:765	the fiber sensor element	742:765	the fiber sensor element which is thinner than a human hair	742:800	The fibers were coaxially coated with a 10 μm thick poly(dimethylsiloxane) dielectric elastomer to form the fiber sensor element which is thinner than a human hair.
33030887	4	66	theme	fiber	746:750	arg1	thinner					776:782	thinner	776:782	thinner	776:782	The fibers were coaxially coated with a 10 μm thick poly(dimethylsiloxane) dielectric elastomer to form the fiber sensor element which is thinner than a human hair.
33030887	6	67	theme	high	1113:1116	arg1	sensitivity					1118:1128	a high sensitivity	1111:1128	a high sensitivity of 5.49 kPa-1	1111:1142	In the touch mode, a fiber-based sensor experienced monotonic capacitance increase in the pressure range from 0 to 460 kPa, and a linear response with a high sensitivity of 5.49 kPa-1 was obtained in the low-pressure regime (<0.5 kPa).
33030887	9	68	theme	touchless	1460:1468	arg1	piano					1470:1474	a touchless piano	1458:1474	a touchless piano	1458:1474	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	9	68	theme	touchless	1460:1468	arg1	array					1432:1436	A fiber sensor array	1417:1436	A fiber sensor array	1417:1436	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	9	68	theme	touchless	1460:1468	arg1	proximity					1519:1527	the proximity	1515:1527	the proximity of an object	1515:1540	A fiber sensor array is able to serve as a touchless piano to play music and accurately determine the proximity of an object.
33030887	2	69	theme	pressure	364:371	arg1	detection					346:354	sensitive detection	336:354	sensitive detection of both pressure and proximity of human fingers	336:402	We report a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers.
33030887	2	70	theme	sensitive	336:344	arg1	detection					346:354	sensitive detection	336:354	sensitive detection of both pressure and proximity of human fingers	336:402	We report a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers.
33030887	7	71	theme	cm	1283:1284	arg1	distance					1262:1269	a distance	1260:1269	a distance of up to 30 cm	1260:1284	In touchless mode, the sensor is highly sensitive to objects at a distance of up to 30 cm.
33030887	3	72	theme	elongation	602:611	arg1	strain					613:618	elongation strain	602:618	elongation strain of 3.0% at break	602:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	3	73	theme	electrical	524:533	arg1	conductivity					535:546	the electrical conductivity	520:546	the electrical conductivity of 1.3 × 104 S/cm	520:564	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	4	74	theme	μm	681:682	arg1	elastomer					724:732	a 10 μm thick poly(dimethylsiloxane) dielectric elastomer	676:732	a 10 μm thick poly(dimethylsiloxane) dielectric elastomer	676:732	The fibers were coaxially coated with a 10 μm thick poly(dimethylsiloxane) dielectric elastomer to form the fiber sensor element which is thinner than a human hair.
33030887	5	75	theme	fibers	821:826	arg1	Two					803:805	Two	803:805	Two	803:805	Two of the sensor fibers were laid diagonally, and the capacitance changes between the conductive cores were measured in response to pressure and proximity.
33030887	5	75	theme	fibers	821:826	arg1	fibers					821:826	the sensor fibers	810:826	the sensor fibers	810:826	Two of the sensor fibers were laid diagonally, and the capacitance changes between the conductive cores were measured in response to pressure and proximity.
33030887	2	76	theme	nanowire-bacterial	276:293	arg1	fiber					305:309	a hierarchically porous silver nanowire-bacterial cellulose fiber	245:309	a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers	245:402	We report a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers.
33030887	7	77	from	mode	1209:1212	arg1	sensor					1219:1224	the sensor	1215:1224	the sensor	1215:1224	In touchless mode, the sensor is highly sensitive to objects at a distance of up to 30 cm.
33030887	7	77	from	mode	1209:1212	arg1	sensitive					1236:1244	sensitive	1236:1244	sensitive	1236:1244	In touchless mode, the sensor is highly sensitive to objects at a distance of up to 30 cm.
33030887	5	78	theme	sensor	814:819	arg1	fibers					821:826	the sensor fibers	810:826	the sensor fibers	810:826	Two of the sensor fibers were laid diagonally, and the capacitance changes between the conductive cores were measured in response to pressure and proximity.
33030887	0	79	theme	Sensitive	76:84	arg1	Detection					86:94	Highly Sensitive Detection	69:94	Highly Sensitive Detection of Pressure and Proximity	69:120	Silver Nanowire-Bacterial Cellulose Composite Fiber-Based Sensor for Highly Sensitive Detection of Pressure and Proximity.
33030887	2	80	theme	silver	269:274	arg1	fiber					305:309	a hierarchically porous silver nanowire-bacterial cellulose fiber	245:309	a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers	245:402	We report a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers.
33030887	3	81	from	speed	475:479	arg1	wet-spinning					457:468	continuous wet-spinning	446:468	continuous wet-spinning at a speed of 20 m/min	446:491	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
33030887	2	82	theme	fingers	396:402	arg1	detection					346:354	sensitive detection	336:354	sensitive detection of both pressure and proximity of human fingers	336:402	We report a hierarchically porous silver nanowire-bacterial cellulose fiber that can be utilized for sensitive detection of both pressure and proximity of human fingers.
33030887	3	83	from	conductivity	535:546	arg1	break					631:635	break	631:635	break	631:635	The conductive fiber was synthesized via continuous wet-spinning at a speed of 20 m/min, with a diameter of 53 μm, the electrical conductivity of 1.3 × 104 S/cm, a tensile strength of 198 MPa, and elongation strain of 3.0% at break.
32809809	0	0	theme	Calcium	94:100	arg1	Complexes					106:114	Calcium Ion Complexes	94:114	Calcium Ion Complexes	94:114	Supramolecular Biocomposite Hydrogels Formed by Cellulose and Host-Guest Polymers Assisted by Calcium Ion Complexes.
32809809	8	1	theme	calcium	1117:1123	arg1	complexes					1136:1144	calcium ion (Ca2+) complexes	1117:1144	calcium ion (Ca2+) complexes between the CAC and p-αCD/p-AADA	1117:1177	Then, calcium chloride solution (CaCl2) was used to form calcium ion (Ca2+) complexes between the CAC and p-αCD/p-AADA.
32809809	5	2	theme	acid	654:657	arg1	p-AADA					674:679	p-AADA	674:679	p-AADA	674:679	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	5	2	theme	acid	654:657	arg1	polymer					665:671	a dodecanoic acid guest polymer	641:671	a dodecanoic acid guest polymer (p-AADA)	641:680	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	9	3	theme	relative	1340:1347	arg1	properties					1329:1338	improved mechanical properties	1309:1338	improved mechanical properties relative to p-αCD/p-AADA hydrogels	1309:1373	This approach successfully created supramolecular biocomposite hydrogels assisted by Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+) with improved mechanical properties relative to p-αCD/p-AADA hydrogels; the toughness was increased 6-fold, from 1 to 6 MJ/m3.
32809809	8	4	theme	ion	1125:1127	arg1	complexes					1136:1144	calcium ion (Ca2+) complexes	1117:1144	calcium ion (Ca2+) complexes between the CAC and p-αCD/p-AADA	1117:1177	Then, calcium chloride solution (CaCl2) was used to form calcium ion (Ca2+) complexes between the CAC and p-αCD/p-AADA.
32809809	5	5	theme	guest	659:663	arg1	p-AADA					674:679	p-AADA	674:679	p-AADA	674:679	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	5	5	theme	guest	659:663	arg1	polymer					665:671	a dodecanoic acid guest polymer	641:671	a dodecanoic acid guest polymer (p-AADA)	641:680	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	5	6	theme	host	616:619	arg1	polymer					621:627	an acrylamide-based αCD host polymer	592:627	an acrylamide-based αCD host polymer (p-αCD)	592:635	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	5	6	theme	host	616:619	arg1	p-αCD					630:634	p-αCD	630:634	p-αCD	630:634	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	7	7	from	p-αCD/p-AADA	1026:1037	arg1	p-αCD/p-AADA/CAC					1042:1057	p-αCD/p-AADA/CAC	1042:1057	p-αCD/p-AADA/CAC	1042:1057	This was caused by the strong intramolecular hydrogen bonding (H-bonding) within the CAC, which prevented the CAC reinforcing p-αCD/p-AADA in p-αCD/p-AADA/CAC.
32809809	9	8	theme	supramolecular	1215:1228	arg1	hydrogels					1243:1251	supramolecular biocomposite hydrogels	1215:1251	supramolecular biocomposite hydrogels assisted by Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+)	1215:1302	This approach successfully created supramolecular biocomposite hydrogels assisted by Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+) with improved mechanical properties relative to p-αCD/p-AADA hydrogels; the toughness was increased 6-fold, from 1 to 6 MJ/m3.
32809809	10	9	theme	mechanical	1435:1444	arg1	properties					1446:1455	The mechanical properties	1431:1455	The mechanical properties	1431:1455	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	9	10	theme	Ca2+	1265:1268	arg1	p-αCD/p-AADA/CAC/Ca2+					1281:1301	p-αCD/p-AADA/CAC/Ca2+	1281:1301	p-αCD/p-AADA/CAC/Ca2+	1281:1301	This approach successfully created supramolecular biocomposite hydrogels assisted by Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+) with improved mechanical properties relative to p-αCD/p-AADA hydrogels; the toughness was increased 6-fold, from 1 to 6 MJ/m3.
32809809	9	10	theme	Ca2+	1265:1268	arg1	complexes					1270:1278	Ca2+ complexes	1265:1278	Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+)	1265:1302	This approach successfully created supramolecular biocomposite hydrogels assisted by Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+) with improved mechanical properties relative to p-αCD/p-AADA hydrogels; the toughness was increased 6-fold, from 1 to 6 MJ/m3.
32809809	9	11	dep	6	1422:1422	arg1	to					1419:1420	to	1419:1420	to	1419:1420	This approach successfully created supramolecular biocomposite hydrogels assisted by Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+) with improved mechanical properties relative to p-αCD/p-AADA hydrogels; the toughness was increased 6-fold, from 1 to 6 MJ/m3.
32809809	0	12	theme	Ion	102:104	arg1	Complexes					106:114	Calcium Ion Complexes	94:114	Calcium Ion Complexes	94:114	Supramolecular Biocomposite Hydrogels Formed by Cellulose and Host-Guest Polymers Assisted by Calcium Ion Complexes.
32809809	9	13	theme	improved	1309:1316	arg1	properties					1329:1338	improved mechanical properties	1309:1338	improved mechanical properties relative to p-αCD/p-AADA hydrogels	1309:1373	This approach successfully created supramolecular biocomposite hydrogels assisted by Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+) with improved mechanical properties relative to p-αCD/p-AADA hydrogels; the toughness was increased 6-fold, from 1 to 6 MJ/m3.
32809809	6	14	theme	biocomposite	792:803	arg1	p-αCD/p-AADA/CAC					816:831	p-αCD/p-AADA/CAC	816:831	p-αCD/p-AADA/CAC	816:831	However, when CAC was directly added to p-αCD/p-AADA to form biocomposite hydrogels (p-αCD/p-AADA/CAC), it showed weaker mechanical properties than p-αCD/p-AADA itself.
32809809	6	14	theme	biocomposite	792:803	arg1	hydrogels					805:813	biocomposite hydrogels	792:813	biocomposite hydrogels (p-αCD/p-AADA/CAC)	792:832	However, when CAC was directly added to p-αCD/p-AADA to form biocomposite hydrogels (p-αCD/p-AADA/CAC), it showed weaker mechanical properties than p-αCD/p-AADA itself.
32809809	1	15	dep	networks	153:160	arg1	have					177:180	have	177:180	have the disadvantage of having poor mechanical properties	177:234	Hydrogels are biocompatible polymer networks; however, they have the disadvantage of having poor mechanical properties.
32809809	10	16	theme	CAC	1616:1618	arg1	p-AADA					1624:1629	p-AADA	1624:1629	p-AADA	1624:1629	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	10	16	theme	CAC	1616:1618	arg1	CAC					1616:1618	CAC	1616:1618	CAC	1616:1618	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	10	16	theme	CAC	1616:1618	arg1	groups					1606:1611	the carboxyl groups	1593:1611	the carboxyl groups of CAC and p-AADA	1593:1629	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	9	17	theme	mechanical	1318:1327	arg1	properties					1329:1338	improved mechanical properties	1309:1338	improved mechanical properties relative to p-αCD/p-AADA hydrogels	1309:1373	This approach successfully created supramolecular biocomposite hydrogels assisted by Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+) with improved mechanical properties relative to p-αCD/p-AADA hydrogels; the toughness was increased 6-fold, from 1 to 6 MJ/m3.
32809809	10	18	theme	complex	1567:1573	arg1	formation					1575:1583	subsequent complex formation	1556:1583	subsequent complex formation between the carboxyl groups of CAC and p-AADA	1556:1629	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	4	19	theme	carboxyl	498:505	arg1	groups					507:512	many carboxyl groups	493:512	many carboxyl groups	493:512	Citric acid-modified cellulose (CAC) with many carboxyl groups was used instead of conventional cellulose.
32809809	8	20	used	used	1104:1107	arg2	CaCl2					1093:1097	CaCl2	1093:1097	CaCl2	1093:1097	Then, calcium chloride solution (CaCl2) was used to form calcium ion (Ca2+) complexes between the CAC and p-αCD/p-AADA.
32809809	8	20	used	used	1104:1107	arg2	solution					1083:1090	calcium chloride solution	1066:1090	calcium chloride solution (CaCl2)	1066:1098	Then, calcium chloride solution (CaCl2) was used to form calcium ion (Ca2+) complexes between the CAC and p-αCD/p-AADA.
32809809	7	21	theme	intramolecular	930:943	arg1	bonding					954:960	the strong intramolecular hydrogen bonding	919:960	the strong intramolecular hydrogen bonding (H-bonding) within the CAC, which prevented the CAC reinforcing p-αCD/p-AADA in p-αCD/p-AADA/CAC	919:1057	This was caused by the strong intramolecular hydrogen bonding (H-bonding) within the CAC, which prevented the CAC reinforcing p-αCD/p-AADA in p-αCD/p-AADA/CAC.
32809809	2	22	theme	hydrogels	285:293	arg1	properties					260:269	the mechanical properties	245:269	the mechanical properties of host-guest hydrogels	245:293	Herein, the mechanical properties of host-guest hydrogels were increased by adding a filler and incorporating other noncovalent interactions.
32809809	9	23	theme	biocomposite	1230:1241	arg1	hydrogels					1243:1251	supramolecular biocomposite hydrogels	1215:1251	supramolecular biocomposite hydrogels assisted by Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+)	1215:1302	This approach successfully created supramolecular biocomposite hydrogels assisted by Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+) with improved mechanical properties relative to p-αCD/p-AADA hydrogels; the toughness was increased 6-fold, from 1 to 6 MJ/m3.
32809809	10	24	theme	subsequent	1556:1565	arg1	formation					1575:1583	subsequent complex formation	1556:1583	subsequent complex formation between the carboxyl groups of CAC and p-AADA	1556:1629	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	0	25	theme	Biocomposite	15:26	arg1	Hydrogels					28:36	Supramolecular Biocomposite Hydrogels	0:36	Supramolecular Biocomposite Hydrogels	0:36	Supramolecular Biocomposite Hydrogels Formed by Cellulose and Host-Guest Polymers Assisted by Calcium Ion Complexes.
32809809	4	26	theme	many	493:496	arg1	groups					507:512	many carboxyl groups	493:512	many carboxyl groups	493:512	Citric acid-modified cellulose (CAC) with many carboxyl groups was used instead of conventional cellulose.
32809809	8	27	theme	calcium	1066:1072	arg1	CaCl2					1093:1097	CaCl2	1093:1097	CaCl2	1093:1097	Then, calcium chloride solution (CaCl2) was used to form calcium ion (Ca2+) complexes between the CAC and p-αCD/p-AADA.
32809809	8	27	theme	calcium	1066:1072	arg1	solution					1083:1090	calcium chloride solution	1066:1090	calcium chloride solution (CaCl2)	1066:1098	Then, calcium chloride solution (CaCl2) was used to form calcium ion (Ca2+) complexes between the CAC and p-αCD/p-AADA.
32809809	7	28	theme	hydrogen	945:952	arg1	bonding					954:960	the strong intramolecular hydrogen bonding	919:960	the strong intramolecular hydrogen bonding (H-bonding) within the CAC, which prevented the CAC reinforcing p-αCD/p-AADA in p-αCD/p-AADA/CAC	919:1057	This was caused by the strong intramolecular hydrogen bonding (H-bonding) within the CAC, which prevented the CAC reinforcing p-αCD/p-AADA in p-αCD/p-AADA/CAC.
32809809	4	29	with	cellulose	472:480	arg1	groups					507:512	many carboxyl groups	493:512	many carboxyl groups	493:512	Citric acid-modified cellulose (CAC) with many carboxyl groups was used instead of conventional cellulose.
32809809	0	30	theme	Supramolecular	0:13	arg1	Hydrogels					28:36	Supramolecular Biocomposite Hydrogels	0:36	Supramolecular Biocomposite Hydrogels	0:36	Supramolecular Biocomposite Hydrogels Formed by Cellulose and Host-Guest Polymers Assisted by Calcium Ion Complexes.
32809809	5	31	theme	dodecanoic	643:652	arg1	p-AADA					674:679	p-AADA	674:679	p-AADA	674:679	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	5	31	theme	dodecanoic	643:652	arg1	polymer					665:671	a dodecanoic acid guest polymer	641:671	a dodecanoic acid guest polymer (p-AADA)	641:680	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	5	32	theme	acrylamide-based	595:610	arg1	polymer					621:627	an acrylamide-based αCD host polymer	592:627	an acrylamide-based αCD host polymer (p-αCD)	592:635	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	5	32	theme	acrylamide-based	595:610	arg1	p-αCD					630:634	p-αCD	630:634	p-αCD	630:634	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	6	33	theme	mechanical	852:861	arg1	properties					863:872	weaker mechanical properties	845:872	weaker mechanical properties	845:872	However, when CAC was directly added to p-αCD/p-AADA to form biocomposite hydrogels (p-αCD/p-AADA/CAC), it showed weaker mechanical properties than p-αCD/p-AADA itself.
32809809	9	34	theme	p-αCD/p-AADA	1352:1363	arg1	hydrogels					1365:1373	p-αCD/p-AADA hydrogels	1352:1373	p-αCD/p-AADA hydrogels	1352:1373	This approach successfully created supramolecular biocomposite hydrogels assisted by Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+) with improved mechanical properties relative to p-αCD/p-AADA hydrogels; the toughness was increased 6-fold, from 1 to 6 MJ/m3.
32809809	5	35	theme	supramolecular	690:703	arg1	hydrogels					705:713	supramolecular hydrogels	690:713	supramolecular hydrogels (p-αCD/p-AADA)	690:728	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	5	35	theme	supramolecular	690:703	arg1	p-αCD/p-AADA					716:727	p-αCD/p-AADA	716:727	p-αCD/p-AADA	716:727	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	5	36	theme	αCD	612:614	arg1	polymer					621:627	an acrylamide-based αCD host polymer	592:627	an acrylamide-based αCD host polymer (p-αCD)	592:635	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	5	36	theme	αCD	612:614	arg1	p-αCD					630:634	p-αCD	630:634	p-αCD	630:634	The preparation began with mixing an acrylamide-based αCD host polymer (p-αCD) and a dodecanoic acid guest polymer (p-AADA) to form supramolecular hydrogels (p-αCD/p-AADA).
32809809	10	37	theme	carboxyl	1597:1604	arg1	p-AADA					1624:1629	p-AADA	1624:1629	p-AADA	1624:1629	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	10	37	theme	carboxyl	1597:1604	arg1	CAC					1616:1618	CAC	1616:1618	CAC	1616:1618	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	10	37	theme	carboxyl	1597:1604	arg1	groups					1606:1611	the carboxyl groups	1593:1611	the carboxyl groups of CAC and p-AADA	1593:1629	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	8	38	theme	chloride	1074:1081	arg1	CaCl2					1093:1097	CaCl2	1093:1097	CaCl2	1093:1097	Then, calcium chloride solution (CaCl2) was used to form calcium ion (Ca2+) complexes between the CAC and p-αCD/p-AADA.
32809809	8	38	theme	chloride	1074:1081	arg1	solution					1083:1090	calcium chloride solution	1066:1090	calcium chloride solution (CaCl2)	1066:1098	Then, calcium chloride solution (CaCl2) was used to form calcium ion (Ca2+) complexes between the CAC and p-αCD/p-AADA.
32809809	1	39	theme	poor	209:212	arg1	properties					225:234	poor mechanical properties	209:234	poor mechanical properties	209:234	Hydrogels are biocompatible polymer networks; however, they have the disadvantage of having poor mechanical properties.
32809809	0	40	theme	Cellulose	48:56	arg1	Polymers					73:80	Cellulose and Host-Guest Polymers	48:80	Cellulose and Host-Guest Polymers Assisted by Calcium Ion Complexes	48:114	Supramolecular Biocomposite Hydrogels Formed by Cellulose and Host-Guest Polymers Assisted by Calcium Ion Complexes.
32809809	2	41	theme	noncovalent	353:363	arg1	interactions					365:376	other noncovalent interactions	347:376	other noncovalent interactions	347:376	Herein, the mechanical properties of host-guest hydrogels were increased by adding a filler and incorporating other noncovalent interactions.
32809809	4	42	theme	acid-modified	458:470	arg1	cellulose					472:480	Citric acid-modified cellulose	451:480	Citric acid-modified cellulose (CAC) with many carboxyl groups	451:512	Citric acid-modified cellulose (CAC) with many carboxyl groups was used instead of conventional cellulose.
32809809	4	42	theme	acid-modified	458:470	arg1	CAC					483:485	CAC	483:485	CAC	483:485	Citric acid-modified cellulose (CAC) with many carboxyl groups was used instead of conventional cellulose.
32809809	11	43	theme	hydrogels	1708:1716	arg1	properties					1694:1703	the mechanical properties	1679:1703	the mechanical properties of hydrogels that can be broadly applied as biomaterials	1679:1760	This mechanism is a new approach for improving the mechanical properties of hydrogels that can be broadly applied as biomaterials.
32809809	1	44	theme	mechanical	214:223	arg1	properties					225:234	poor mechanical properties	209:234	poor mechanical properties	209:234	Hydrogels are biocompatible polymer networks; however, they have the disadvantage of having poor mechanical properties.
32809809	4	45	theme	conventional	534:545	arg1	cellulose					547:555	conventional cellulose	534:555	conventional cellulose	534:555	Citric acid-modified cellulose (CAC) with many carboxyl groups was used instead of conventional cellulose.
32809809	6	46	theme	weaker	845:850	arg1	properties					863:872	weaker mechanical properties	845:872	weaker mechanical properties	845:872	However, when CAC was directly added to p-αCD/p-AADA to form biocomposite hydrogels (p-αCD/p-AADA/CAC), it showed weaker mechanical properties than p-αCD/p-AADA itself.
32809809	0	47	theme	Host-Guest	62:71	arg1	Polymers					73:80	Cellulose and Host-Guest Polymers	48:80	Cellulose and Host-Guest Polymers Assisted by Calcium Ion Complexes	48:114	Supramolecular Biocomposite Hydrogels Formed by Cellulose and Host-Guest Polymers Assisted by Calcium Ion Complexes.
32809809	1	48	contain	have	177:180	arg2	disadvantage					186:197	the disadvantage	182:197	the disadvantage of having poor mechanical properties	182:234	Hydrogels are biocompatible polymer networks; however, they have the disadvantage of having poor mechanical properties.
32809809	1	48	contain	have	177:180	arg1	they					172:175	they	172:175	they	172:175	Hydrogels are biocompatible polymer networks; however, they have the disadvantage of having poor mechanical properties.
32809809	7	49	theme	CAC	1010:1012	arg1	p-αCD/p-AADA					1026:1037	the CAC reinforcing p-αCD/p-AADA	1006:1037	the CAC reinforcing p-αCD/p-AADA in p-αCD/p-AADA/CAC	1006:1057	This was caused by the strong intramolecular hydrogen bonding (H-bonding) within the CAC, which prevented the CAC reinforcing p-αCD/p-AADA in p-αCD/p-AADA/CAC.
32809809	10	50	theme	intramolecular	1504:1517	arg1	disruption					1486:1495	the disruption	1482:1495	the disruption of the intramolecular H-bonding within the CAC	1482:1542	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	9	51	theme	assisted	1253:1260	arg1	hydrogels					1243:1251	supramolecular biocomposite hydrogels	1215:1251	supramolecular biocomposite hydrogels assisted by Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+)	1215:1302	This approach successfully created supramolecular biocomposite hydrogels assisted by Ca2+ complexes (p-αCD/p-AADA/CAC/Ca2+) with improved mechanical properties relative to p-αCD/p-AADA hydrogels; the toughness was increased 6-fold, from 1 to 6 MJ/m3.
32809809	1	52	theme	biocompatible	131:143	arg1	networks					153:160	biocompatible polymer networks	131:160	biocompatible polymer networks; however, they have the disadvantage of having poor mechanical properties	131:234	Hydrogels are biocompatible polymer networks; however, they have the disadvantage of having poor mechanical properties.
32809809	1	52	theme	biocompatible	131:143	arg1	Hydrogels					117:125	Hydrogels	117:125	Hydrogels	117:125	Hydrogels are biocompatible polymer networks; however, they have the disadvantage of having poor mechanical properties.
32809809	7	53	dep	bonding	954:960	arg1	H-bonding					963:971	H-bonding	963:971	H-bonding	963:971	This was caused by the strong intramolecular hydrogen bonding (H-bonding) within the CAC, which prevented the CAC reinforcing p-αCD/p-AADA in p-αCD/p-AADA/CAC.
32809809	7	54	theme	strong	923:928	arg1	bonding					954:960	the strong intramolecular hydrogen bonding	919:960	the strong intramolecular hydrogen bonding (H-bonding) within the CAC, which prevented the CAC reinforcing p-αCD/p-AADA in p-αCD/p-AADA/CAC	919:1057	This was caused by the strong intramolecular hydrogen bonding (H-bonding) within the CAC, which prevented the CAC reinforcing p-αCD/p-AADA in p-αCD/p-AADA/CAC.
32809809	7	55	theme	reinforcing	1014:1024	arg1	p-αCD/p-AADA					1026:1037	the CAC reinforcing p-αCD/p-AADA	1006:1037	the CAC reinforcing p-αCD/p-AADA in p-αCD/p-AADA/CAC	1006:1057	This was caused by the strong intramolecular hydrogen bonding (H-bonding) within the CAC, which prevented the CAC reinforcing p-αCD/p-AADA in p-αCD/p-AADA/CAC.
32809809	8	56	dep	CAC	1158:1160	arg1	the					1154:1156	the	1154:1156	the	1154:1156	Then, calcium chloride solution (CaCl2) was used to form calcium ion (Ca2+) complexes between the CAC and p-αCD/p-AADA.
32809809	2	57	theme	host-guest	274:283	arg1	hydrogels					285:293	host-guest hydrogels	274:293	host-guest hydrogels	274:293	Herein, the mechanical properties of host-guest hydrogels were increased by adding a filler and incorporating other noncovalent interactions.
32809809	1	58	theme	polymer	145:151	arg1	networks					153:160	biocompatible polymer networks	131:160	biocompatible polymer networks; however, they have the disadvantage of having poor mechanical properties	131:234	Hydrogels are biocompatible polymer networks; however, they have the disadvantage of having poor mechanical properties.
32809809	1	58	theme	polymer	145:151	arg1	Hydrogels					117:125	Hydrogels	117:125	Hydrogels	117:125	Hydrogels are biocompatible polymer networks; however, they have the disadvantage of having poor mechanical properties.
32809809	10	59	theme	H-bonding	1519:1527	arg1	intramolecular					1504:1517	the intramolecular	1500:1517	the intramolecular H-bonding within the CAC	1500:1542	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	4	60	theme	Citric	451:456	arg1	cellulose					472:480	Citric acid-modified cellulose	451:480	Citric acid-modified cellulose (CAC) with many carboxyl groups	451:512	Citric acid-modified cellulose (CAC) with many carboxyl groups was used instead of conventional cellulose.
32809809	4	60	theme	Citric	451:456	arg1	CAC					483:485	CAC	483:485	CAC	483:485	Citric acid-modified cellulose (CAC) with many carboxyl groups was used instead of conventional cellulose.
32809809	11	61	theme	new	1652:1654	arg1	mechanism					1637:1645	This mechanism	1632:1645	This mechanism	1632:1645	This mechanism is a new approach for improving the mechanical properties of hydrogels that can be broadly applied as biomaterials.
32809809	11	61	theme	new	1652:1654	arg1	approach					1656:1663	a new approach	1650:1663	a new approach for improving the mechanical properties of hydrogels that can be broadly applied as biomaterials	1650:1760	This mechanism is a new approach for improving the mechanical properties of hydrogels that can be broadly applied as biomaterials.
32809809	2	62	theme	other	347:351	arg1	interactions					365:376	other noncovalent interactions	347:376	other noncovalent interactions	347:376	Herein, the mechanical properties of host-guest hydrogels were increased by adding a filler and incorporating other noncovalent interactions.
32809809	0	63	theme	Assisted	82:89	arg1	Polymers					73:80	Cellulose and Host-Guest Polymers	48:80	Cellulose and Host-Guest Polymers Assisted by Calcium Ion Complexes	48:114	Supramolecular Biocomposite Hydrogels Formed by Cellulose and Host-Guest Polymers Assisted by Calcium Ion Complexes.
32809809	1	64	contain	having	202:207	arg1	disadvantage					186:197	the disadvantage	182:197	the disadvantage of having poor mechanical properties	182:234	Hydrogels are biocompatible polymer networks; however, they have the disadvantage of having poor mechanical properties.
32809809	1	64	contain	having	202:207	arg2	properties					225:234	poor mechanical properties	209:234	poor mechanical properties	209:234	Hydrogels are biocompatible polymer networks; however, they have the disadvantage of having poor mechanical properties.
32809809	11	65	theme	mechanical	1683:1692	arg1	properties					1694:1703	the mechanical properties	1679:1703	the mechanical properties of hydrogels that can be broadly applied as biomaterials	1679:1760	This mechanism is a new approach for improving the mechanical properties of hydrogels that can be broadly applied as biomaterials.
32809809	10	66	theme	p-AADA	1624:1629	arg1	p-AADA					1624:1629	p-AADA	1624:1629	p-AADA	1624:1629	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	10	66	theme	p-AADA	1624:1629	arg1	CAC					1616:1618	CAC	1616:1618	CAC	1616:1618	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	10	66	theme	p-AADA	1624:1629	arg1	groups					1606:1611	the carboxyl groups	1593:1611	the carboxyl groups of CAC and p-AADA	1593:1629	The mechanical properties were improved because of the disruption of the intramolecular H-bonding within the CAC by Ca2+ and subsequent complex formation between the carboxyl groups of CAC and p-AADA.
32809809	2	67	theme	mechanical	249:258	arg1	properties					260:269	the mechanical properties	245:269	the mechanical properties of host-guest hydrogels	245:293	Herein, the mechanical properties of host-guest hydrogels were increased by adding a filler and incorporating other noncovalent interactions.
32809809	4	68	used	used	518:521	arg2	CAC					483:485	CAC	483:485	CAC	483:485	Citric acid-modified cellulose (CAC) with many carboxyl groups was used instead of conventional cellulose.
32809809	4	68	used	used	518:521	arg2	cellulose					472:480	Citric acid-modified cellulose	451:480	Citric acid-modified cellulose (CAC) with many carboxyl groups	451:512	Citric acid-modified cellulose (CAC) with many carboxyl groups was used instead of conventional cellulose.
32809809	8	69	theme	Ca2+	1130:1133	arg1	complexes					1136:1144	calcium ion (Ca2+) complexes	1117:1144	calcium ion (Ca2+) complexes between the CAC and p-αCD/p-AADA	1117:1177	Then, calcium chloride solution (CaCl2) was used to form calcium ion (Ca2+) complexes between the CAC and p-αCD/p-AADA.
34153358	5	0	theme	minor	959:963	arg1	effect					965:970	a minor effect	957:970	a minor effect on the S-plasticized film's thermal properties	957:1017	Varying plasticizer concentrations exhibited a minor effect on the S-plasticized film's thermal properties.
34153358	6	1	theme	plasticizer	1135:1145	arg1	contents					1147:1154	the plasticizer contents	1131:1154	the plasticizer contents	1131:1154	Significant decrement in the glass transition temperatures of Dioscorea hispida starch films was observed when the plasticizer contents were raised from 30% to 60%.
34153358	4	2	with	films	842:846	arg1	concentrations					876:889	increasing plasticizer concentrations	853:889	increasing plasticizer concentrations of the film samples	853:909	The tensile strengths were decreased, but elongations at break were increased; 7.38%-11.54% for G-plasticized films, 10.17%-15.76% for S-plasticized films, and 14.41%- 16.10% for SG-plasticized films with increasing plasticizer concentrations of the film samples.
34153358	4	3	theme	increasing	853:862	arg1	concentrations					876:889	increasing plasticizer concentrations	853:889	increasing plasticizer concentrations of the film samples	853:909	The tensile strengths were decreased, but elongations at break were increased; 7.38%-11.54% for G-plasticized films, 10.17%-15.76% for S-plasticized films, and 14.41%- 16.10% for SG-plasticized films with increasing plasticizer concentrations of the film samples.
34153358	6	4	theme	films	1107:1111	arg1	temperatures					1066:1077	the glass transition temperatures	1045:1077	the glass transition temperatures of Dioscorea hispida starch films	1045:1111	Significant decrement in the glass transition temperatures of Dioscorea hispida starch films was observed when the plasticizer contents were raised from 30% to 60%.
34153358	6	5	dep	%	1182:1182	arg1	to					1177:1178	to	1177:1178	to	1177:1178	Significant decrement in the glass transition temperatures of Dioscorea hispida starch films was observed when the plasticizer contents were raised from 30% to 60%.
34153358	0	6	theme	films	85:89	arg1	properties					57:66	physical, thermal, and tensile properties	26:66	physical, thermal, and tensile properties of thermoplastic films	26:89	Effect of plasticizers on physical, thermal, and tensile properties of thermoplastic films based on Dioscorea hispida starch.
34153358	1	7	theme	Dioscorea	291:299	arg1	films					323:327	Dioscorea hispida, starch-based films	291:327	films	323:327	This study examines the effects of varying the concentrations of sorbitol (S) and glycerol (G) on the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films.
34153358	4	8	theme	%	731:731	arg1	%					738:738	7.38%-11.54%	727:738	7.38%-11.54% for G-plasticized films	727:762	The tensile strengths were decreased, but elongations at break were increased; 7.38%-11.54% for G-plasticized films, 10.17%-15.76% for S-plasticized films, and 14.41%- 16.10% for SG-plasticized films with increasing plasticizer concentrations of the film samples.
34153358	2	9	theme	0	539:539	arg1	ratios					529:534	the ratios	525:534	the ratios of 0, 30, 45, and 60 wt%	525:559	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	6	10	theme	Significant	1020:1030	arg1	decrement					1032:1040	Significant decrement	1020:1040	Significant decrement in the glass transition temperatures of Dioscorea hispida starch films	1020:1111	Significant decrement in the glass transition temperatures of Dioscorea hispida starch films was observed when the plasticizer contents were raised from 30% to 60%.
34153358	0	11	theme	thermoplastic	71:83	arg1	films					85:89	thermoplastic films	71:89	thermoplastic films	71:89	Effect of plasticizers on physical, thermal, and tensile properties of thermoplastic films based on Dioscorea hispida starch.
34153358	1	12	theme	hispida	301:307	arg1	films					323:327	Dioscorea hispida, starch-based films	291:327	films	323:327	This study examines the effects of varying the concentrations of sorbitol (S) and glycerol (G) on the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films.
34153358	2	13	theme	sorbitol-glycerol	483:499	arg1	glycerol					438:445	glycerol	438:445	glycerol (G)	438:449	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	2	13	theme	sorbitol-glycerol	483:499	arg1	mixture					472:478	a mixture	470:478	a mixture of sorbitol-glycerol (SG)	470:504	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	2	13	theme	sorbitol-glycerol	483:499	arg1	S					462:462	S	462:462	S	462:462	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	2	13	theme	sorbitol-glycerol	483:499	arg1	G					448:448	G	448:448	G	448:448	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	2	13	theme	sorbitol-glycerol	483:499	arg1	sorbitol					452:459	sorbitol	452:459	sorbitol (S)	452:463	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	4	14	theme	S-plasticized	783:795	arg1	films					797:801	S-plasticized films	783:801	S-plasticized films	783:801	The tensile strengths were decreased, but elongations at break were increased; 7.38%-11.54% for G-plasticized films, 10.17%-15.76% for S-plasticized films, and 14.41%- 16.10% for SG-plasticized films with increasing plasticizer concentrations of the film samples.
34153358	3	15	theme	moisture	573:580	arg1	contents					582:589	The films' moisture contents	562:589	The films' moisture contents	562:589	The films' moisture contents were increased when increasing the plasticizer contents.
34153358	6	16	from	decrement	1032:1040	arg1	temperatures					1066:1077	the glass transition temperatures	1045:1077	the glass transition temperatures of Dioscorea hispida starch films	1045:1111	Significant decrement in the glass transition temperatures of Dioscorea hispida starch films was observed when the plasticizer contents were raised from 30% to 60%.
34153358	7	17	theme	hispida	1254:1260	arg1	starch					1262:1267	plasticized Dioscorea hispida starch	1232:1267	plasticized Dioscorea hispida starch	1232:1267	Significantly, the present work has shown that plasticized Dioscorea hispida starch can be considered a promising biopolymer for the applications of biodegradable films.
34153358	0	18	theme	thermal	36:42	arg1	properties					57:66	physical, thermal, and tensile properties	26:66	physical, thermal, and tensile properties of thermoplastic films	26:89	Effect of plasticizers on physical, thermal, and tensile properties of thermoplastic films based on Dioscorea hispida starch.
34153358	1	19	theme	starch-based	310:321	arg1	films					323:327	Dioscorea hispida, starch-based films	291:327	films	323:327	This study examines the effects of varying the concentrations of sorbitol (S) and glycerol (G) on the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films.
34153358	5	20	from	effect	965:970	arg1	properties					1008:1017	the S-plasticized film's thermal properties	975:1017	the S-plasticized film's thermal properties	975:1017	Varying plasticizer concentrations exhibited a minor effect on the S-plasticized film's thermal properties.
34153358	5	21	theme	plasticizer	920:930	arg1	concentrations					932:945	Varying plasticizer concentrations	912:945	Varying plasticizer concentrations	912:945	Varying plasticizer concentrations exhibited a minor effect on the S-plasticized film's thermal properties.
34153358	4	22	theme	SG-plasticized	827:840	arg1	films					842:846	SG-plasticized films	827:846	SG-plasticized films with increasing plasticizer concentrations of the film samples	827:909	The tensile strengths were decreased, but elongations at break were increased; 7.38%-11.54% for G-plasticized films, 10.17%-15.76% for S-plasticized films, and 14.41%- 16.10% for SG-plasticized films with increasing plasticizer concentrations of the film samples.
34153358	1	23	theme	films	323:327	arg1	properties					277:286	the physical, morphological, thermal, and mechanical properties	224:286	the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films	224:327	This study examines the effects of varying the concentrations of sorbitol (S) and glycerol (G) on the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films.
34153358	6	24	theme	starch	1100:1105	arg1	films					1107:1111	Dioscorea hispida starch films	1082:1111	Dioscorea hispida starch films	1082:1111	Significant decrement in the glass transition temperatures of Dioscorea hispida starch films was observed when the plasticizer contents were raised from 30% to 60%.
34153358	2	25	theme	45	546:547	arg1	ratios					529:534	the ratios	525:534	the ratios of 0, 30, 45, and 60 wt%	525:559	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	7	26	theme	plasticized	1232:1242	arg1	starch					1262:1267	plasticized Dioscorea hispida starch	1232:1267	plasticized Dioscorea hispida starch	1232:1267	Significantly, the present work has shown that plasticized Dioscorea hispida starch can be considered a promising biopolymer for the applications of biodegradable films.
34153358	4	27	from	break	705:709	arg1	elongations					690:700	elongations	690:700	elongations at break	690:709	The tensile strengths were decreased, but elongations at break were increased; 7.38%-11.54% for G-plasticized films, 10.17%-15.76% for S-plasticized films, and 14.41%- 16.10% for SG-plasticized films with increasing plasticizer concentrations of the film samples.
34153358	2	28	theme	starch	378:383	arg1	films					351:355	the films	347:355	the films of Dioscorea hispida starch	347:383	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	5	29	theme	thermal	1000:1006	arg1	properties					1008:1017	the S-plasticized film's thermal properties	975:1017	the S-plasticized film's thermal properties	975:1017	Varying plasticizer concentrations exhibited a minor effect on the S-plasticized film's thermal properties.
34153358	6	30	theme	hispida	1092:1098	arg1	films					1107:1111	Dioscorea hispida starch films	1082:1111	Dioscorea hispida starch films	1082:1111	Significant decrement in the glass transition temperatures of Dioscorea hispida starch films was observed when the plasticizer contents were raised from 30% to 60%.
34153358	7	31	theme	Dioscorea	1244:1252	arg1	starch					1262:1267	plasticized Dioscorea hispida starch	1232:1267	plasticized Dioscorea hispida starch	1232:1267	Significantly, the present work has shown that plasticized Dioscorea hispida starch can be considered a promising biopolymer for the applications of biodegradable films.
34153358	2	32	theme	hispida	370:376	arg1	starch					378:383	Dioscorea hispida starch	360:383	Dioscorea hispida starch	360:383	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	1	33	theme	physical	228:235	arg1	properties					277:286	the physical, morphological, thermal, and mechanical properties	224:286	the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films	224:327	This study examines the effects of varying the concentrations of sorbitol (S) and glycerol (G) on the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films.
34153358	0	34	theme	hispida	110:116	arg1	starch					118:123	Dioscorea hispida starch	100:123	Dioscorea hispida starch	100:123	Effect of plasticizers on physical, thermal, and tensile properties of thermoplastic films based on Dioscorea hispida starch.
34153358	2	35	theme	30	542:543	arg1	ratios					529:534	the ratios	525:534	the ratios of 0, 30, 45, and 60 wt%	525:559	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	0	36	theme	plasticizers	10:21	arg1	Effect					0:5	Effect	0:5	Effect of plasticizers on physical, thermal, and tensile properties of thermoplastic films	0:89	Effect of plasticizers on physical, thermal, and tensile properties of thermoplastic films based on Dioscorea hispida starch.
34153358	0	37	theme	Dioscorea	100:108	arg1	starch					118:123	Dioscorea hispida starch	100:123	Dioscorea hispida starch	100:123	Effect of plasticizers on physical, thermal, and tensile properties of thermoplastic films based on Dioscorea hispida starch.
34153358	2	38	theme	casting	415:421	arg1	plasticizers					509:520	plasticizers	509:520	plasticizers at the ratios of 0, 30, 45, and 60 wt%	509:559	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	2	38	theme	casting	415:421	arg1	technique					423:431	solution casting technique	406:431	solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG)	406:504	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	1	39	theme	morphological	238:250	arg1	properties					277:286	the physical, morphological, thermal, and mechanical properties	224:286	the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films	224:327	This study examines the effects of varying the concentrations of sorbitol (S) and glycerol (G) on the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films.
34153358	4	40	theme	%	770:770	arg1	%					777:777	10.17%-15.76%	765:777	10.17%-15.76% for S-plasticized films	765:801	The tensile strengths were decreased, but elongations at break were increased; 7.38%-11.54% for G-plasticized films, 10.17%-15.76% for S-plasticized films, and 14.41%- 16.10% for SG-plasticized films with increasing plasticizer concentrations of the film samples.
34153358	6	41	theme	Dioscorea	1082:1090	arg1	films					1107:1111	Dioscorea hispida starch films	1082:1111	Dioscorea hispida starch films	1082:1111	Significant decrement in the glass transition temperatures of Dioscorea hispida starch films was observed when the plasticizer contents were raised from 30% to 60%.
34153358	1	42	theme	sorbitol	191:198	arg1	concentrations					173:186	the concentrations	169:186	the concentrations of sorbitol (S) and glycerol (G)	169:219	This study examines the effects of varying the concentrations of sorbitol (S) and glycerol (G) on the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films.
34153358	2	43	theme	solution	406:413	arg1	plasticizers					509:520	plasticizers	509:520	plasticizers at the ratios of 0, 30, 45, and 60 wt%	509:559	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	2	43	theme	solution	406:413	arg1	technique					423:431	solution casting technique	406:431	solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG)	406:504	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	3	44	theme	plasticizer	626:636	arg1	contents					638:645	the plasticizer contents	622:645	the plasticizer contents	622:645	The films' moisture contents were increased when increasing the plasticizer contents.
34153358	0	45	theme	physical	26:33	arg1	properties					57:66	physical, thermal, and tensile properties	26:66	physical, thermal, and tensile properties of thermoplastic films	26:89	Effect of plasticizers on physical, thermal, and tensile properties of thermoplastic films based on Dioscorea hispida starch.
34153358	6	46	theme	%	1175:1175	arg1	%					1182:1182	30% to 60%	1173:1182	30% to 60%	1173:1182	Significant decrement in the glass transition temperatures of Dioscorea hispida starch films was observed when the plasticizer contents were raised from 30% to 60%.
34153358	7	47	theme	present	1204:1210	arg1	work					1212:1215	the present work	1200:1215	the present work	1200:1215	Significantly, the present work has shown that plasticized Dioscorea hispida starch can be considered a promising biopolymer for the applications of biodegradable films.
34153358	1	48	theme	thermal	253:259	arg1	properties					277:286	the physical, morphological, thermal, and mechanical properties	224:286	the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films	224:327	This study examines the effects of varying the concentrations of sorbitol (S) and glycerol (G) on the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films.
34153358	5	49	theme	Varying	912:918	arg1	concentrations					932:945	Varying plasticizer concentrations	912:945	Varying plasticizer concentrations	912:945	Varying plasticizer concentrations exhibited a minor effect on the S-plasticized film's thermal properties.
34153358	7	50	theme	promising	1289:1297	arg1	biopolymer					1299:1308	a promising biopolymer	1287:1308	a promising biopolymer for the applications of biodegradable films	1287:1352	Significantly, the present work has shown that plasticized Dioscorea hispida starch can be considered a promising biopolymer for the applications of biodegradable films.
34153358	2	51	theme	%	559:559	arg1	ratios					529:534	the ratios	525:534	the ratios of 0, 30, 45, and 60 wt%	525:559	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	0	52	from	Effect	0:5	arg1	properties					57:66	physical, thermal, and tensile properties	26:66	physical, thermal, and tensile properties of thermoplastic films	26:89	Effect of plasticizers on physical, thermal, and tensile properties of thermoplastic films based on Dioscorea hispida starch.
34153358	6	53	theme	transition	1055:1064	arg1	temperatures					1066:1077	the glass transition temperatures	1045:1077	the glass transition temperatures of Dioscorea hispida starch films	1045:1111	Significant decrement in the glass transition temperatures of Dioscorea hispida starch films was observed when the plasticizer contents were raised from 30% to 60%.
34153358	2	54	theme	60 wt	554:558	arg1	%					559:559	60 wt%	554:559	60 wt%	554:559	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	2	55	from	ratios	529:534	arg1	plasticizers					509:520	plasticizers	509:520	plasticizers at the ratios of 0, 30, 45, and 60 wt%	509:559	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	2	55	from	ratios	529:534	arg1	technique					423:431	solution casting technique	406:431	solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG)	406:504	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	4	56	theme	film	898:901	arg1	samples					903:909	the film samples	894:909	the film samples	894:909	The tensile strengths were decreased, but elongations at break were increased; 7.38%-11.54% for G-plasticized films, 10.17%-15.76% for S-plasticized films, and 14.41%- 16.10% for SG-plasticized films with increasing plasticizer concentrations of the film samples.
34153358	4	57	theme	tensile	652:658	arg1	strengths					660:668	The tensile strengths	648:668	The tensile strengths	648:668	The tensile strengths were decreased, but elongations at break were increased; 7.38%-11.54% for G-plasticized films, 10.17%-15.76% for S-plasticized films, and 14.41%- 16.10% for SG-plasticized films with increasing plasticizer concentrations of the film samples.
34153358	4	58	theme	G-plasticized	744:756	arg1	films					758:762	G-plasticized films	744:762	G-plasticized films	744:762	The tensile strengths were decreased, but elongations at break were increased; 7.38%-11.54% for G-plasticized films, 10.17%-15.76% for S-plasticized films, and 14.41%- 16.10% for SG-plasticized films with increasing plasticizer concentrations of the film samples.
34153358	6	59	theme	glass	1049:1053	arg1	temperatures					1066:1077	the glass transition temperatures	1045:1077	the glass transition temperatures of Dioscorea hispida starch films	1045:1111	Significant decrement in the glass transition temperatures of Dioscorea hispida starch films was observed when the plasticizer contents were raised from 30% to 60%.
34153358	2	60	with	technique	423:431	arg1	glycerol					438:445	glycerol	438:445	glycerol (G)	438:449	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	2	60	with	technique	423:431	arg1	mixture					472:478	a mixture	470:478	a mixture of sorbitol-glycerol (SG)	470:504	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	2	60	with	technique	423:431	arg1	S					462:462	S	462:462	S	462:462	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	2	60	with	technique	423:431	arg1	G					448:448	G	448:448	G	448:448	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	2	60	with	technique	423:431	arg1	sorbitol					452:459	sorbitol	452:459	sorbitol (S)	452:463	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	5	61	theme	S-plasticized	979:991	arg1	film					993:996	the S-plasticized film's	975:998	the S-plasticized film's thermal properties	975:1017	Varying plasticizer concentrations exhibited a minor effect on the S-plasticized film's thermal properties.
34153358	7	62	theme	biodegradable	1334:1346	arg1	films					1348:1352	biodegradable films	1334:1352	biodegradable films	1334:1352	Significantly, the present work has shown that plasticized Dioscorea hispida starch can be considered a promising biopolymer for the applications of biodegradable films.
34153358	0	63	theme	tensile	49:55	arg1	properties					57:66	physical, thermal, and tensile properties	26:66	physical, thermal, and tensile properties of thermoplastic films	26:89	Effect of plasticizers on physical, thermal, and tensile properties of thermoplastic films based on Dioscorea hispida starch.
34153358	7	64	theme	films	1348:1352	arg1	applications					1318:1329	the applications	1314:1329	the applications of biodegradable films	1314:1352	Significantly, the present work has shown that plasticized Dioscorea hispida starch can be considered a promising biopolymer for the applications of biodegradable films.
34153358	4	65	theme	samples	903:909	arg1	concentrations					876:889	increasing plasticizer concentrations	853:889	increasing plasticizer concentrations of the film samples	853:909	The tensile strengths were decreased, but elongations at break were increased; 7.38%-11.54% for G-plasticized films, 10.17%-15.76% for S-plasticized films, and 14.41%- 16.10% for SG-plasticized films with increasing plasticizer concentrations of the film samples.
34153358	1	66	theme	mechanical	266:275	arg1	properties					277:286	the physical, morphological, thermal, and mechanical properties	224:286	the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films	224:327	This study examines the effects of varying the concentrations of sorbitol (S) and glycerol (G) on the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films.
34153358	2	67	theme	Dioscorea	360:368	arg1	starch					378:383	Dioscorea hispida starch	360:383	Dioscorea hispida starch	360:383	In this context, the films of Dioscorea hispida starch were developed using solution casting technique with glycerol (G), sorbitol (S), and a mixture of sorbitol-glycerol (SG) as plasticizers at the ratios of 0, 30, 45, and 60 wt%.
34153358	1	68	from	effects	150:156	arg1	properties					277:286	the physical, morphological, thermal, and mechanical properties	224:286	the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films	224:327	This study examines the effects of varying the concentrations of sorbitol (S) and glycerol (G) on the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films.
34153358	4	69	theme	plasticizer	864:874	arg1	concentrations					876:889	increasing plasticizer concentrations	853:889	increasing plasticizer concentrations of the film samples	853:909	The tensile strengths were decreased, but elongations at break were increased; 7.38%-11.54% for G-plasticized films, 10.17%-15.76% for S-plasticized films, and 14.41%- 16.10% for SG-plasticized films with increasing plasticizer concentrations of the film samples.
34153358	1	70	theme	glycerol	208:215	arg1	concentrations					173:186	the concentrations	169:186	the concentrations of sorbitol (S) and glycerol (G)	169:219	This study examines the effects of varying the concentrations of sorbitol (S) and glycerol (G) on the physical, morphological, thermal, and mechanical properties of Dioscorea hispida, starch-based films.
34469838	0	0	with	properties	39:48	arg1	tristearate					85:95	sorbitan tristearate	76:95	sorbitan tristearate	76:95	Tailoring crystallization and physical properties of palm mid-fraction with sorbitan tristearate and sucrose stearate.
34469838	0	0	with	properties	39:48	arg1	stearate					109:116	sucrose stearate	101:116	sucrose stearate	101:116	Tailoring crystallization and physical properties of palm mid-fraction with sorbitan tristearate and sucrose stearate.
34469838	3	1	theme	transformation	527:540	arg1	rate					513:516	rate	513:516	rate	513:516	DSC results corroborate the polymorphism analysis, indicating that the mechanism and rate of phase transformation depend on the chemical structure and amount of each emulsifier.
34469838	3	1	theme	transformation	527:540	arg1	mechanism					499:507	mechanism	499:507	mechanism	499:507	DSC results corroborate the polymorphism analysis, indicating that the mechanism and rate of phase transformation depend on the chemical structure and amount of each emulsifier.
34469838	1	2	theme	physical	170:177	arg1	transformations					179:193	physical transformations	170:193	physical transformations of palm mid-fraction (PMF)	170:220	This paper addresses sorbitan and sucrose ester in physical transformations of palm mid-fraction (PMF).
34469838	6	3	theme	liquid	990:995	arg1	fraction					997:1004	the liquid fraction	986:1004	the liquid fraction	986:1004	We can conclude that the presence of emulsifiers dissimilar to the composition of PMF modified its physical structure, either by increasing the liquid fraction or by reducing molecular motion, facilitating or preventing polymorphic transformations.
34469838	4	4	theme	crystallization	751:765	arg1	behavior					767:774	the crystallization behavior	747:774	the crystallization behavior	747:774	The addition of sorbitan tristearate (STS) and sucrose stearate (S-370) increased the crystallization speed of the PMF and caused changes in the crystallization behavior.
34469838	4	5	theme	sorbitan	622:629	arg1	STS					644:646	STS	644:646	STS	644:646	The addition of sorbitan tristearate (STS) and sucrose stearate (S-370) increased the crystallization speed of the PMF and caused changes in the crystallization behavior.
34469838	4	5	theme	sorbitan	622:629	arg1	tristearate					631:641	sorbitan tristearate	622:641	sorbitan tristearate (STS)	622:647	The addition of sorbitan tristearate (STS) and sucrose stearate (S-370) increased the crystallization speed of the PMF and caused changes in the crystallization behavior.
34469838	0	6	theme	sucrose	101:107	arg1	stearate					109:116	sucrose stearate	101:116	sucrose stearate	101:116	Tailoring crystallization and physical properties of palm mid-fraction with sorbitan tristearate and sucrose stearate.
34469838	6	7	theme	dissimilar	895:904	arg1	emulsifiers					883:893	emulsifiers	883:893	emulsifiers dissimilar to the composition of PMF	883:930	We can conclude that the presence of emulsifiers dissimilar to the composition of PMF modified its physical structure, either by increasing the liquid fraction or by reducing molecular motion, facilitating or preventing polymorphic transformations.
34469838	2	8	theme	due	297:299	arg1	PMF					285:287	PMF	285:287	PMF	285:287	Both emulsifiers influenced the crystallization properties of PMF, mainly due to emulsifier solubility, which affects its ability to interfere with the kinetics of solution-mediated phase transformations.
34469838	6	9	theme	emulsifiers	883:893	arg1	presence					871:878	the presence	867:878	the presence of emulsifiers dissimilar to the composition of PMF	867:930	We can conclude that the presence of emulsifiers dissimilar to the composition of PMF modified its physical structure, either by increasing the liquid fraction or by reducing molecular motion, facilitating or preventing polymorphic transformations.
34469838	1	10	from	ester	161:165	arg1	transformations					179:193	physical transformations	170:193	physical transformations of palm mid-fraction (PMF)	170:220	This paper addresses sorbitan and sucrose ester in physical transformations of palm mid-fraction (PMF).
34469838	3	11	theme	chemical	556:563	arg1	structure					565:573	chemical structure	556:573	chemical structure	556:573	DSC results corroborate the polymorphism analysis, indicating that the mechanism and rate of phase transformation depend on the chemical structure and amount of each emulsifier.
34469838	1	12	theme	palm	198:201	arg1	PMF					217:219	PMF	217:219	PMF	217:219	This paper addresses sorbitan and sucrose ester in physical transformations of palm mid-fraction (PMF).
34469838	1	12	theme	palm	198:201	arg1	mid-fraction					203:214	palm mid-fraction	198:214	palm mid-fraction (PMF)	198:220	This paper addresses sorbitan and sucrose ester in physical transformations of palm mid-fraction (PMF).
34469838	2	13	theme	transformations	411:425	arg1	kinetics					375:382	the kinetics	371:382	the kinetics of solution-mediated phase transformations	371:425	Both emulsifiers influenced the crystallization properties of PMF, mainly due to emulsifier solubility, which affects its ability to interfere with the kinetics of solution-mediated phase transformations.
34469838	3	14	theme	DSC	428:430	arg1	results					432:438	DSC results	428:438	DSC results	428:438	DSC results corroborate the polymorphism analysis, indicating that the mechanism and rate of phase transformation depend on the chemical structure and amount of each emulsifier.
34469838	1	15	from	sorbitan	140:147	arg1	transformations					179:193	physical transformations	170:193	physical transformations of palm mid-fraction (PMF)	170:220	This paper addresses sorbitan and sucrose ester in physical transformations of palm mid-fraction (PMF).
34469838	2	16	theme	phase	405:409	arg1	transformations					411:425	solution-mediated phase transformations	387:425	solution-mediated phase transformations	387:425	Both emulsifiers influenced the crystallization properties of PMF, mainly due to emulsifier solubility, which affects its ability to interfere with the kinetics of solution-mediated phase transformations.
34469838	3	17	theme	emulsifier	594:603	arg1	amount					579:584	amount	579:584	amount	579:584	DSC results corroborate the polymorphism analysis, indicating that the mechanism and rate of phase transformation depend on the chemical structure and amount of each emulsifier.
34469838	3	17	theme	emulsifier	594:603	arg1	emulsifier					594:603	each emulsifier	589:603	each emulsifier	589:603	DSC results corroborate the polymorphism analysis, indicating that the mechanism and rate of phase transformation depend on the chemical structure and amount of each emulsifier.
34469838	3	17	theme	emulsifier	594:603	arg1	structure					565:573	chemical structure	556:573	chemical structure	556:573	DSC results corroborate the polymorphism analysis, indicating that the mechanism and rate of phase transformation depend on the chemical structure and amount of each emulsifier.
34469838	2	18	theme	solution-mediated	387:403	arg1	transformations					411:425	solution-mediated phase transformations	387:425	solution-mediated phase transformations	387:425	Both emulsifiers influenced the crystallization properties of PMF, mainly due to emulsifier solubility, which affects its ability to interfere with the kinetics of solution-mediated phase transformations.
34469838	6	19	theme	PMF	928:930	arg1	composition					913:923	the composition	909:923	the composition of PMF	909:930	We can conclude that the presence of emulsifiers dissimilar to the composition of PMF modified its physical structure, either by increasing the liquid fraction or by reducing molecular motion, facilitating or preventing polymorphic transformations.
34469838	1	20	theme	mid-fraction	203:214	arg1	transformations					179:193	physical transformations	170:193	physical transformations of palm mid-fraction (PMF)	170:220	This paper addresses sorbitan and sucrose ester in physical transformations of palm mid-fraction (PMF).
34469838	0	21	theme	physical	30:37	arg1	properties					39:48	physical properties	30:48	physical properties	30:48	Tailoring crystallization and physical properties of palm mid-fraction with sorbitan tristearate and sucrose stearate.
34469838	4	22	theme	sucrose	653:659	arg1	stearate					661:668	sucrose stearate	653:668	sucrose stearate (S-370)	653:676	The addition of sorbitan tristearate (STS) and sucrose stearate (S-370) increased the crystallization speed of the PMF and caused changes in the crystallization behavior.
34469838	4	22	theme	sucrose	653:659	arg1	S-370					671:675	S-370	671:675	S-370	671:675	The addition of sorbitan tristearate (STS) and sucrose stearate (S-370) increased the crystallization speed of the PMF and caused changes in the crystallization behavior.
34469838	6	23	dep	modified	932:939	arg1	facilitating					1039:1050	facilitating	1039:1050	facilitating	1039:1050	We can conclude that the presence of emulsifiers dissimilar to the composition of PMF modified its physical structure, either by increasing the liquid fraction or by reducing molecular motion, facilitating or preventing polymorphic transformations.
34469838	6	23	dep	modified	932:939	arg1	increasing					975:984	increasing	975:984	increasing the liquid fraction	975:1004	We can conclude that the presence of emulsifiers dissimilar to the composition of PMF modified its physical structure, either by increasing the liquid fraction or by reducing molecular motion, facilitating or preventing polymorphic transformations.
34469838	6	23	dep	modified	932:939	arg1	reducing					1012:1019	reducing	1012:1019	reducing molecular motion	1012:1036	We can conclude that the presence of emulsifiers dissimilar to the composition of PMF modified its physical structure, either by increasing the liquid fraction or by reducing molecular motion, facilitating or preventing polymorphic transformations.
34469838	6	23	dep	modified	932:939	arg1	preventing					1055:1064	preventing	1055:1064	preventing polymorphic transformations	1055:1092	We can conclude that the presence of emulsifiers dissimilar to the composition of PMF modified its physical structure, either by increasing the liquid fraction or by reducing molecular motion, facilitating or preventing polymorphic transformations.
34469838	2	24	theme	emulsifier	304:313	arg1	solubility					315:324	emulsifier solubility	304:324	emulsifier solubility	304:324	Both emulsifiers influenced the crystallization properties of PMF, mainly due to emulsifier solubility, which affects its ability to interfere with the kinetics of solution-mediated phase transformations.
34469838	3	25	dep	structure	565:573	arg1	the					552:554	the	552:554	the	552:554	DSC results corroborate the polymorphism analysis, indicating that the mechanism and rate of phase transformation depend on the chemical structure and amount of each emulsifier.
34469838	3	26	theme	polymorphism	456:467	arg1	analysis					469:476	the polymorphism analysis	452:476	the polymorphism analysis	452:476	DSC results corroborate the polymorphism analysis, indicating that the mechanism and rate of phase transformation depend on the chemical structure and amount of each emulsifier.
34469838	6	27	theme	polymorphic	1066:1076	arg1	transformations					1078:1092	polymorphic transformations	1066:1092	polymorphic transformations	1066:1092	We can conclude that the presence of emulsifiers dissimilar to the composition of PMF modified its physical structure, either by increasing the liquid fraction or by reducing molecular motion, facilitating or preventing polymorphic transformations.
34469838	6	28	theme	physical	945:952	arg1	structure					954:962	its physical structure	941:962	its physical structure	941:962	We can conclude that the presence of emulsifiers dissimilar to the composition of PMF modified its physical structure, either by increasing the liquid fraction or by reducing molecular motion, facilitating or preventing polymorphic transformations.
34469838	4	29	theme	stearate	661:668	arg1	addition					610:617	The addition	606:617	The addition of sorbitan tristearate (STS) and sucrose stearate (S-370)	606:676	The addition of sorbitan tristearate (STS) and sucrose stearate (S-370) increased the crystallization speed of the PMF and caused changes in the crystallization behavior.
34469838	0	30	theme	mid-fraction	58:69	arg1	crystallization					10:24	crystallization	10:24	crystallization	10:24	Tailoring crystallization and physical properties of palm mid-fraction with sorbitan tristearate and sucrose stearate.
34469838	0	30	theme	mid-fraction	58:69	arg1	properties					39:48	physical properties	30:48	physical properties	30:48	Tailoring crystallization and physical properties of palm mid-fraction with sorbitan tristearate and sucrose stearate.
34469838	0	31	theme	palm	53:56	arg1	mid-fraction					58:69	palm mid-fraction	53:69	palm mid-fraction	53:69	Tailoring crystallization and physical properties of palm mid-fraction with sorbitan tristearate and sucrose stearate.
34469838	0	32	with	crystallization	10:24	arg1	tristearate					85:95	sorbitan tristearate	76:95	sorbitan tristearate	76:95	Tailoring crystallization and physical properties of palm mid-fraction with sorbitan tristearate and sucrose stearate.
34469838	0	32	with	crystallization	10:24	arg1	stearate					109:116	sucrose stearate	101:116	sucrose stearate	101:116	Tailoring crystallization and physical properties of palm mid-fraction with sorbitan tristearate and sucrose stearate.
34469838	3	33	theme	phase	521:525	arg1	transformation					527:540	phase transformation	521:540	phase transformation	521:540	DSC results corroborate the polymorphism analysis, indicating that the mechanism and rate of phase transformation depend on the chemical structure and amount of each emulsifier.
34469838	4	34	from	changes	736:742	arg1	behavior					767:774	the crystallization behavior	747:774	the crystallization behavior	747:774	The addition of sorbitan tristearate (STS) and sucrose stearate (S-370) increased the crystallization speed of the PMF and caused changes in the crystallization behavior.
34469838	3	35	dep	mechanism	499:507	arg1	the					495:497	the	495:497	the	495:497	DSC results corroborate the polymorphism analysis, indicating that the mechanism and rate of phase transformation depend on the chemical structure and amount of each emulsifier.
34469838	2	36	theme	PMF	285:287	arg1	properties					271:280	the crystallization properties	251:280	the crystallization properties of PMF, mainly due to emulsifier solubility, which affects its ability to interfere with the kinetics of solution-mediated phase transformations	251:425	Both emulsifiers influenced the crystallization properties of PMF, mainly due to emulsifier solubility, which affects its ability to interfere with the kinetics of solution-mediated phase transformations.
34469838	6	37	theme	molecular	1021:1029	arg1	motion					1031:1036	molecular motion	1021:1036	molecular motion	1021:1036	We can conclude that the presence of emulsifiers dissimilar to the composition of PMF modified its physical structure, either by increasing the liquid fraction or by reducing molecular motion, facilitating or preventing polymorphic transformations.
34469838	4	38	theme	tristearate	631:641	arg1	addition					610:617	The addition	606:617	The addition of sorbitan tristearate (STS) and sucrose stearate (S-370)	606:676	The addition of sorbitan tristearate (STS) and sucrose stearate (S-370) increased the crystallization speed of the PMF and caused changes in the crystallization behavior.
34469838	0	39	theme	sorbitan	76:83	arg1	tristearate					85:95	sorbitan tristearate	76:95	sorbitan tristearate	76:95	Tailoring crystallization and physical properties of palm mid-fraction with sorbitan tristearate and sucrose stearate.
34469838	1	40	theme	sucrose	153:159	arg1	ester					161:165	sucrose ester	153:165	sucrose ester	153:165	This paper addresses sorbitan and sucrose ester in physical transformations of palm mid-fraction (PMF).
34469838	5	41	theme	→β	795:796	arg1	transition					798:807	the β'→β transition	789:807	the β'→β transition	789:807	STS favored the β'→β transition, while S-370 stabilized the β'-form.
34469838	2	42	theme	crystallization	255:269	arg1	properties					271:280	the crystallization properties	251:280	the crystallization properties of PMF, mainly due to emulsifier solubility, which affects its ability to interfere with the kinetics of solution-mediated phase transformations	251:425	Both emulsifiers influenced the crystallization properties of PMF, mainly due to emulsifier solubility, which affects its ability to interfere with the kinetics of solution-mediated phase transformations.
34469838	4	43	theme	crystallization	692:706	arg1	speed					708:712	the crystallization speed	688:712	the crystallization speed of the PMF	688:723	The addition of sorbitan tristearate (STS) and sucrose stearate (S-370) increased the crystallization speed of the PMF and caused changes in the crystallization behavior.
34469838	4	44	theme	PMF	721:723	arg1	speed					708:712	the crystallization speed	688:712	the crystallization speed of the PMF	688:723	The addition of sorbitan tristearate (STS) and sucrose stearate (S-370) increased the crystallization speed of the PMF and caused changes in the crystallization behavior.
32173434	0	0	theme	alcohol	82:88	arg1	properties					47:56	multifunctional properties	31:56	multifunctional properties of chitosan/poly (vinyl alcohol)	31:89	Influence of boswellic acid on multifunctional properties of chitosan/poly (vinyl alcohol) films for active food packaging.
32173434	1	1	theme	BA	283:284	arg1	effect					273:278	the effect	269:278	the effect of BA on multifunctional properties of CS/PVA (CPBA) active films	269:344	Present work aimed to develop active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA), and to evaluate the effect of BA on multifunctional properties of CS/PVA (CPBA) active films.
32173434	1	2	theme	vinyl	207:211	arg1	poly					201:204	poly	201:204	poly (vinyl alcohol) (PVA)	201:226	Present work aimed to develop active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA), and to evaluate the effect of BA on multifunctional properties of CS/PVA (CPBA) active films.
32173434	1	2	theme	vinyl	207:211	arg1	alcohol					213:219	vinyl alcohol	207:219	vinyl alcohol	207:219	Present work aimed to develop active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA), and to evaluate the effect of BA on multifunctional properties of CS/PVA (CPBA) active films.
32173434	2	3	theme	films	390:394	arg1	compositions					357:368	Different compositions	347:368	Different compositions of active packaging films	347:394	Different compositions of active packaging films were prepared by the solvent casting method.
32173434	3	4	theme	CPBA	601:604	arg1	films					613:617	the CPBA active films	597:617	the CPBA active films	597:617	The results indicated that incorporation of BA enhanced the ultraviolet blocking, morphology, mechanical properties, water solubility and hydrophilicity of the CPBA active films.
32173434	1	5	theme	active	333:338	arg1	films					340:344	CS/PVA (CPBA) active films	319:344	CS/PVA (CPBA) active films	319:344	Present work aimed to develop active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA), and to evaluate the effect of BA on multifunctional properties of CS/PVA (CPBA) active films.
32173434	4	6	dep	incorporated	677:688	arg1	BA					674:675	BA	674:675	BA	674:675	Significant improvement in the barriers properties of BA incorporated CPBA active films were observed.
32173434	8	7	theme	promising	1172:1180	arg1	material					1182:1189	a promising material	1170:1189	a promising material for food packaging applications	1170:1221	The obtained results indicate that the CPBA active film may be a promising material for food packaging applications.
32173434	8	7	theme	promising	1172:1180	arg1	film					1158:1161	the CPBA active film	1142:1161	the CPBA active film	1142:1161	The obtained results indicate that the CPBA active film may be a promising material for food packaging applications.
32173434	6	8	theme	thermal	942:948	arg1	properties					950:959	the thermal properties	938:959	the thermal properties after incorporation of BA	938:985	Furthermore, the prepared active films do not deteriorate the thermal properties after incorporation of BA.
32173434	0	9	from	Influence	0:8	arg1	properties					47:56	multifunctional properties	31:56	multifunctional properties of chitosan/poly (vinyl alcohol)	31:89	Influence of boswellic acid on multifunctional properties of chitosan/poly (vinyl alcohol) films for active food packaging.
32173434	1	10	theme	films	340:344	arg1	properties					305:314	multifunctional properties	289:314	multifunctional properties of CS/PVA (CPBA) active films	289:344	Present work aimed to develop active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA), and to evaluate the effect of BA on multifunctional properties of CS/PVA (CPBA) active films.
32173434	4	11	theme	CPBA	690:693	arg1	films					702:706	BA incorporated CPBA active films	674:706	BA incorporated CPBA active films	674:706	Significant improvement in the barriers properties of BA incorporated CPBA active films were observed.
32173434	2	12	theme	casting	425:431	arg1	method					433:438	the solvent casting method	413:438	the solvent casting method	413:438	Different compositions of active packaging films were prepared by the solvent casting method.
32173434	7	13	theme	food	1058:1061	arg1	simulants					1063:1071	food simulants	1058:1071	food simulants	1058:1071	The overall migration values of the CPBA active films in contact with food simulants were within the permitted limits.
32173434	7	14	theme	permitted	1089:1097	arg1	limits					1099:1104	the permitted limits	1085:1104	the permitted limits	1085:1104	The overall migration values of the CPBA active films in contact with food simulants were within the permitted limits.
32173434	4	15	theme	incorporated	677:688	arg1	films					702:706	BA incorporated CPBA active films	674:706	BA incorporated CPBA active films	674:706	Significant improvement in the barriers properties of BA incorporated CPBA active films were observed.
32173434	7	16	with	contact	1045:1051	arg1	simulants					1063:1071	food simulants	1058:1071	food simulants	1058:1071	The overall migration values of the CPBA active films in contact with food simulants were within the permitted limits.
32173434	0	17	theme	active	101:106	arg1	packaging					113:121	active food packaging	101:121	active food packaging	101:121	Influence of boswellic acid on multifunctional properties of chitosan/poly (vinyl alcohol) films for active food packaging.
32173434	8	18	theme	food	1195:1198	arg1	applications					1210:1221	food packaging applications	1195:1221	food packaging applications	1195:1221	The obtained results indicate that the CPBA active film may be a promising material for food packaging applications.
32173434	4	19	theme	films	702:706	arg1	properties					660:669	the barriers properties	647:669	the barriers properties of BA incorporated CPBA active films	647:706	Significant improvement in the barriers properties of BA incorporated CPBA active films were observed.
32173434	1	20	theme	active	154:159	arg1	films					171:175	active packaging films	154:175	active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA)	154:250	Present work aimed to develop active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA), and to evaluate the effect of BA on multifunctional properties of CS/PVA (CPBA) active films.
32173434	8	21	theme	obtained	1111:1118	arg1	results					1120:1126	The obtained results	1107:1126	The obtained results	1107:1126	The obtained results indicate that the CPBA active film may be a promising material for food packaging applications.
32173434	2	22	theme	packaging	380:388	arg1	films					390:394	active packaging films	373:394	active packaging films	373:394	Different compositions of active packaging films were prepared by the solvent casting method.
32173434	7	23	theme	CPBA	1024:1027	arg1	films					1036:1040	the CPBA active films	1020:1040	the CPBA active films in contact with food simulants	1020:1071	The overall migration values of the CPBA active films in contact with food simulants were within the permitted limits.
32173434	4	24	theme	active	695:700	arg1	films					702:706	BA incorporated CPBA active films	674:706	BA incorporated CPBA active films	674:706	Significant improvement in the barriers properties of BA incorporated CPBA active films were observed.
32173434	6	25	theme	active	906:911	arg1	films					913:917	the prepared active films	893:917	the prepared active films	893:917	Furthermore, the prepared active films do not deteriorate the thermal properties after incorporation of BA.
32173434	1	26	theme	packaging	161:169	arg1	films					171:175	active packaging films	154:175	active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA)	154:250	Present work aimed to develop active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA), and to evaluate the effect of BA on multifunctional properties of CS/PVA (CPBA) active films.
32173434	2	27	theme	Different	347:355	arg1	compositions					357:368	Different compositions	347:368	Different compositions of active packaging films	347:394	Different compositions of active packaging films were prepared by the solvent casting method.
32173434	0	28	theme	vinyl	76:80	arg1	alcohol					82:88	chitosan/poly (vinyl alcohol)	61:89	chitosan/poly (vinyl alcohol)	61:89	Influence of boswellic acid on multifunctional properties of chitosan/poly (vinyl alcohol) films for active food packaging.
32173434	7	29	theme	active	1029:1034	arg1	films					1036:1040	the CPBA active films	1020:1040	the CPBA active films in contact with food simulants	1020:1071	The overall migration values of the CPBA active films in contact with food simulants were within the permitted limits.
32173434	7	30	theme	films	1036:1040	arg1	values					1010:1015	The overall migration values	988:1015	The overall migration values of the CPBA active films in contact with food simulants	988:1071	The overall migration values of the CPBA active films in contact with food simulants were within the permitted limits.
32173434	3	31	theme	BA	485:486	arg1	incorporation					468:480	incorporation	468:480	incorporation of BA	468:486	The results indicated that incorporation of BA enhanced the ultraviolet blocking, morphology, mechanical properties, water solubility and hydrophilicity of the CPBA active films.
32173434	3	32	dep	blocking	513:520	arg1	the					497:499	the	497:499	the	497:499	The results indicated that incorporation of BA enhanced the ultraviolet blocking, morphology, mechanical properties, water solubility and hydrophilicity of the CPBA active films.
32173434	0	33	theme	acid	23:26	arg1	Influence					0:8	Influence	0:8	Influence of boswellic acid on multifunctional properties of chitosan/poly (vinyl alcohol)	0:89	Influence of boswellic acid on multifunctional properties of chitosan/poly (vinyl alcohol) films for active food packaging.
32173434	4	34	theme	barriers	651:658	arg1	properties					660:669	the barriers properties	647:669	the barriers properties of BA incorporated CPBA active films	647:706	Significant improvement in the barriers properties of BA incorporated CPBA active films were observed.
32173434	8	35	theme	CPBA	1146:1149	arg1	material					1182:1189	a promising material	1170:1189	a promising material for food packaging applications	1170:1221	The obtained results indicate that the CPBA active film may be a promising material for food packaging applications.
32173434	8	35	theme	CPBA	1146:1149	arg1	film					1158:1161	the CPBA active film	1142:1161	the CPBA active film	1142:1161	The obtained results indicate that the CPBA active film may be a promising material for food packaging applications.
32173434	8	36	theme	packaging	1200:1208	arg1	applications					1210:1221	food packaging applications	1195:1221	food packaging applications	1195:1221	The obtained results indicate that the CPBA active film may be a promising material for food packaging applications.
32173434	1	37	from	effect	273:278	arg1	properties					305:314	multifunctional properties	289:314	multifunctional properties of CS/PVA (CPBA) active films	289:344	Present work aimed to develop active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA), and to evaluate the effect of BA on multifunctional properties of CS/PVA (CPBA) active films.
32173434	0	38	theme	food	108:111	arg1	packaging					113:121	active food packaging	101:121	active food packaging	101:121	Influence of boswellic acid on multifunctional properties of chitosan/poly (vinyl alcohol) films for active food packaging.
32173434	3	39	theme	water	558:562	arg1	solubility					564:573	water solubility	558:573	water solubility	558:573	The results indicated that incorporation of BA enhanced the ultraviolet blocking, morphology, mechanical properties, water solubility and hydrophilicity of the CPBA active films.
32173434	5	40	theme	antimicrobial	774:786	arg1	activity					788:795	the antimicrobial activity	770:795	the antimicrobial activity of the films against Escherichia coli, Staphylococcus aureus and Candida albicans	770:877	The microbiological screening has demonstrated the antimicrobial activity of the films against Escherichia coli, Staphylococcus aureus and Candida albicans.
32173434	0	41	theme	multifunctional	31:45	arg1	properties					47:56	multifunctional properties	31:56	multifunctional properties of chitosan/poly (vinyl alcohol)	31:89	Influence of boswellic acid on multifunctional properties of chitosan/poly (vinyl alcohol) films for active food packaging.
32173434	1	42	theme	boswellic	232:240	arg1	BA					248:249	BA	248:249	BA	248:249	Present work aimed to develop active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA), and to evaluate the effect of BA on multifunctional properties of CS/PVA (CPBA) active films.
32173434	1	42	theme	boswellic	232:240	arg1	acid					242:245	boswellic acid	232:245	boswellic acid (BA)	232:250	Present work aimed to develop active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA), and to evaluate the effect of BA on multifunctional properties of CS/PVA (CPBA) active films.
32173434	1	43	theme	multifunctional	289:303	arg1	properties					305:314	multifunctional properties	289:314	multifunctional properties of CS/PVA (CPBA) active films	289:344	Present work aimed to develop active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA), and to evaluate the effect of BA on multifunctional properties of CS/PVA (CPBA) active films.
32173434	3	44	theme	ultraviolet	501:511	arg1	blocking					513:520	ultraviolet blocking	501:520	ultraviolet blocking	501:520	The results indicated that incorporation of BA enhanced the ultraviolet blocking, morphology, mechanical properties, water solubility and hydrophilicity of the CPBA active films.
32173434	2	45	theme	active	373:378	arg1	films					390:394	active packaging films	373:394	active packaging films	373:394	Different compositions of active packaging films were prepared by the solvent casting method.
32173434	6	46	theme	prepared	897:904	arg1	films					913:917	the prepared active films	893:917	the prepared active films	893:917	Furthermore, the prepared active films do not deteriorate the thermal properties after incorporation of BA.
32173434	8	47	theme	active	1151:1156	arg1	material					1182:1189	a promising material	1170:1189	a promising material for food packaging applications	1170:1221	The obtained results indicate that the CPBA active film may be a promising material for food packaging applications.
32173434	8	47	theme	active	1151:1156	arg1	film					1158:1161	the CPBA active film	1142:1161	the CPBA active film	1142:1161	The obtained results indicate that the CPBA active film may be a promising material for food packaging applications.
32173434	5	48	theme	Candida	862:868	arg1	albicans					870:877	Candida albicans	862:877	Candida albicans	862:877	The microbiological screening has demonstrated the antimicrobial activity of the films against Escherichia coli, Staphylococcus aureus and Candida albicans.
32173434	7	49	theme	overall	992:998	arg1	values					1010:1015	The overall migration values	988:1015	The overall migration values of the CPBA active films in contact with food simulants	988:1071	The overall migration values of the CPBA active films in contact with food simulants were within the permitted limits.
32173434	7	50	from	films	1036:1040	arg1	contact					1045:1051	contact	1045:1051	contact with food simulants	1045:1071	The overall migration values of the CPBA active films in contact with food simulants were within the permitted limits.
32173434	7	51	from	values	1010:1015	arg1	contact					1045:1051	contact	1045:1051	contact with food simulants	1045:1071	The overall migration values of the CPBA active films in contact with food simulants were within the permitted limits.
32173434	3	52	theme	active	606:611	arg1	films					613:617	the CPBA active films	597:617	the CPBA active films	597:617	The results indicated that incorporation of BA enhanced the ultraviolet blocking, morphology, mechanical properties, water solubility and hydrophilicity of the CPBA active films.
32173434	7	53	theme	migration	1000:1008	arg1	values					1010:1015	The overall migration values	988:1015	The overall migration values of the CPBA active films in contact with food simulants	988:1071	The overall migration values of the CPBA active films in contact with food simulants were within the permitted limits.
32173434	4	54	theme	Significant	620:630	arg1	improvement					632:642	Significant improvement	620:642	Significant improvement in the barriers properties of BA incorporated CPBA active films	620:706	Significant improvement in the barriers properties of BA incorporated CPBA active films were observed.
32173434	6	55	theme	BA	984:985	arg1	incorporation					967:979	incorporation	967:979	incorporation of BA	967:985	Furthermore, the prepared active films do not deteriorate the thermal properties after incorporation of BA.
32173434	3	56	theme	mechanical	535:544	arg1	properties					546:555	mechanical properties	535:555	mechanical properties	535:555	The results indicated that incorporation of BA enhanced the ultraviolet blocking, morphology, mechanical properties, water solubility and hydrophilicity of the CPBA active films.
32173434	7	57	from	contact	1045:1051	arg1	values					1010:1015	The overall migration values	988:1015	The overall migration values of the CPBA active films in contact with food simulants	988:1071	The overall migration values of the CPBA active films in contact with food simulants were within the permitted limits.
32173434	1	58	theme	Present	124:130	arg1	work					132:135	Present work	124:135	Present work	124:135	Present work aimed to develop active packaging films based on chitosan (CS), poly (vinyl alcohol) (PVA) and boswellic acid (BA), and to evaluate the effect of BA on multifunctional properties of CS/PVA (CPBA) active films.
32173434	4	59	from	improvement	632:642	arg1	properties					660:669	the barriers properties	647:669	the barriers properties of BA incorporated CPBA active films	647:706	Significant improvement in the barriers properties of BA incorporated CPBA active films were observed.
32173434	2	60	theme	solvent	417:423	arg1	method					433:438	the solvent casting method	413:438	the solvent casting method	413:438	Different compositions of active packaging films were prepared by the solvent casting method.
32173434	5	61	theme	films	804:808	arg1	activity					788:795	the antimicrobial activity	770:795	the antimicrobial activity of the films against Escherichia coli, Staphylococcus aureus and Candida albicans	770:877	The microbiological screening has demonstrated the antimicrobial activity of the films against Escherichia coli, Staphylococcus aureus and Candida albicans.
32173434	0	62	theme	chitosan/poly	61:73	arg1	alcohol					82:88	chitosan/poly (vinyl alcohol)	61:89	chitosan/poly (vinyl alcohol)	61:89	Influence of boswellic acid on multifunctional properties of chitosan/poly (vinyl alcohol) films for active food packaging.
32173434	3	63	theme	films	613:617	arg1	morphology					523:532	morphology	523:532	morphology	523:532	The results indicated that incorporation of BA enhanced the ultraviolet blocking, morphology, mechanical properties, water solubility and hydrophilicity of the CPBA active films.
32173434	3	63	theme	films	613:617	arg1	properties					546:555	mechanical properties	535:555	mechanical properties	535:555	The results indicated that incorporation of BA enhanced the ultraviolet blocking, morphology, mechanical properties, water solubility and hydrophilicity of the CPBA active films.
32173434	3	63	theme	films	613:617	arg1	blocking					513:520	ultraviolet blocking	501:520	ultraviolet blocking	501:520	The results indicated that incorporation of BA enhanced the ultraviolet blocking, morphology, mechanical properties, water solubility and hydrophilicity of the CPBA active films.
32173434	3	63	theme	films	613:617	arg1	solubility					564:573	water solubility	558:573	water solubility	558:573	The results indicated that incorporation of BA enhanced the ultraviolet blocking, morphology, mechanical properties, water solubility and hydrophilicity of the CPBA active films.
32173434	3	63	theme	films	613:617	arg1	hydrophilicity					579:592	hydrophilicity	579:592	hydrophilicity	579:592	The results indicated that incorporation of BA enhanced the ultraviolet blocking, morphology, mechanical properties, water solubility and hydrophilicity of the CPBA active films.
32173434	0	64	theme	boswellic	13:21	arg1	acid					23:26	boswellic acid	13:26	boswellic acid	13:26	Influence of boswellic acid on multifunctional properties of chitosan/poly (vinyl alcohol) films for active food packaging.
32173434	5	65	theme	microbiological	727:741	arg1	screening					743:751	The microbiological screening	723:751	The microbiological screening	723:751	The microbiological screening has demonstrated the antimicrobial activity of the films against Escherichia coli, Staphylococcus aureus and Candida albicans.
33247359	8	0	theme	scaffold	1160:1167	arg1	soaking					1169:1175	Additional scaffold soaking	1149:1175	Additional scaffold soaking in simulated body fluid (SBF)	1149:1205	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	1	1	theme	cartilage	160:168	arg1	areas					186:190	cartilage and subchondral areas	160:190	cartilage and subchondral areas	160:190	Osteochondral defects affect both of cartilage and subchondral areas, thus it poses a significant challenge to simultaneously regenerate two parts in orthopedics.
33247359	8	2	from	medium	1224:1229	arg1	SBF					1202:1204	SBF	1202:1204	SBF	1202:1204	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	8	2	from	medium	1224:1229	arg1	fluid					1195:1199	simulated body fluid	1180:1199	simulated body fluid (SBF)	1180:1205	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	0	3	theme	interface	75:83	arg1	bonding					85:91	enhanced interface bonding	66:91	enhanced interface bonding for hard tissue applications	66:120	3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.
33247359	4	4	theme	material	552:559	arg1	composition					561:571	material composition	552:571	material composition	552:571	One-shot printing process enables control over material composition, pore structure, and size in each region of the scaffold, while realizes seamlessly integrated construct as well.
33247359	8	5	theme	culture	1216:1222	arg1	medium					1224:1229	cell culture medium	1211:1229	cell culture medium	1211:1229	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	8	6	theme	layer	1323:1327	arg1	dislocation					1329:1339	no layer dislocation	1320:1339	no layer dislocation	1320:1339	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	0	7	theme	hard	97:100	arg1	applications					109:120	hard tissue applications	97:120	hard tissue applications	97:120	3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.
33247359	8	8	from	soaking	1169:1175	arg1	SBF					1202:1204	SBF	1202:1204	SBF	1202:1204	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	8	8	from	soaking	1169:1175	arg1	fluid					1195:1199	simulated body fluid	1180:1199	simulated body fluid (SBF)	1180:1205	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	6	9	theme	adhesion	969:976	arg1	strength					978:985	the interface adhesion strength	955:985	the interface adhesion strength between layers	955:1000	The mechanical strength including the interface adhesion strength between layers were characterized.
33247359	4	10	theme	One-shot	505:512	arg1	process					523:529	One-shot printing process	505:529	One-shot printing process	505:529	One-shot printing process enables control over material composition, pore structure, and size in each region of the scaffold, while realizes seamlessly integrated construct as well.
33247359	2	11	theme	engineering	293:303	arg1	strategy					305:312	Tissue engineering strategy	286:312	Tissue engineering strategy	286:312	Tissue engineering strategy is currently regarded as the most promising way to repair osteochondral defects.
33247359	2	11	theme	engineering	293:303	arg1	way					358:360	the most promising way	339:360	the most promising way to repair osteochondral defects	339:392	Tissue engineering strategy is currently regarded as the most promising way to repair osteochondral defects.
33247359	6	12	theme	interface	959:967	arg1	strength					978:985	the interface adhesion strength	955:985	the interface adhesion strength between layers	955:1000	The mechanical strength including the interface adhesion strength between layers were characterized.
33247359	5	13	theme	bioactive	798:806	arg1	MBG					817:819	MBG	817:819	MBG	817:819	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	5	13	theme	bioactive	798:806	arg1	glasses					808:814	mesoporous bioactive glasses	787:814	mesoporous bioactive glasses (MBG)	787:820	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	5	14	dep	designed	704:711	arg1	layer					899:903	a cartilaginous layer	883:903	a cartilaginous layer composed of SA	883:918	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	5	14	dep	designed	704:711	arg1	layer					744:748	a porous bone layer	730:748	a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG)	730:820	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	5	14	dep	designed	704:711	arg1	layer					845:849	an intermediate dense layer	823:849	an intermediate dense layer also composed of SA and MBG	823:877	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	7	15	theme	different	1092:1100	arg1	materials					1102:1110	different materials	1092:1110	different materials together	1092:1119	The results indicated that SA crosslinking after 3D printing anchored different materials together and integrated all regions.
33247359	2	16	theme	Tissue	286:291	arg1	strategy					305:312	Tissue engineering strategy	286:312	Tissue engineering strategy	286:312	Tissue engineering strategy is currently regarded as the most promising way to repair osteochondral defects.
33247359	2	16	theme	Tissue	286:291	arg1	way					358:360	the most promising way	339:360	the most promising way to repair osteochondral defects	339:392	Tissue engineering strategy is currently regarded as the most promising way to repair osteochondral defects.
33247359	1	17	theme	subchondral	174:184	arg1	areas					186:190	cartilage and subchondral areas	160:190	cartilage and subchondral areas	160:190	Osteochondral defects affect both of cartilage and subchondral areas, thus it poses a significant challenge to simultaneously regenerate two parts in orthopedics.
33247359	0	18	theme	tissue	102:107	arg1	applications					109:120	hard tissue applications	97:120	hard tissue applications	97:120	3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.
33247359	8	19	theme	cell	1211:1214	arg1	medium					1224:1229	cell culture medium	1211:1229	cell culture medium	1211:1229	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	3	20	theme	interface	466:474	arg1	bonding					476:482	enhanced interface bonding	457:482	enhanced interface bonding	457:482	This study focuses on developing a multilayered scaffold with enhanced interface bonding through 3D printing.
33247359	4	21	theme	printing	514:521	arg1	process					523:529	One-shot printing process	505:529	One-shot printing process	505:529	One-shot printing process enables control over material composition, pore structure, and size in each region of the scaffold, while realizes seamlessly integrated construct as well.
33247359	5	22	theme	alginate	762:769	arg1	sodium					771:776	alginate sodium	762:776	alginate sodium (SA)	762:781	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	5	22	theme	alginate	762:769	arg1	SA					779:780	SA	779:780	SA	779:780	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	0	23	theme	3D	0:1	arg1	printing					3:10	3D printing	0:10	3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.	0:121	3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.
33247359	8	24	theme	apatite	1239:1245	arg1	deposition					1247:1256	apatite deposition	1239:1256	apatite deposition	1239:1256	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	6	25	theme	mechanical	925:934	arg1	strength					936:943	The mechanical strength	921:943	The mechanical strength including the interface adhesion strength between layers	921:1000	The mechanical strength including the interface adhesion strength between layers were characterized.
33247359	8	26	theme	simulated	1180:1188	arg1	SBF					1202:1204	SBF	1202:1204	SBF	1202:1204	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	8	26	theme	simulated	1180:1188	arg1	fluid					1195:1199	simulated body fluid	1180:1199	simulated body fluid (SBF)	1180:1205	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	3	27	theme	3D	492:493	arg1	printing					495:502	3D printing	492:502	3D printing	492:502	This study focuses on developing a multilayered scaffold with enhanced interface bonding through 3D printing.
33247359	7	28	theme	3D	1071:1072	arg1	printing					1074:1081	3D printing	1071:1081	3D printing	1071:1081	The results indicated that SA crosslinking after 3D printing anchored different materials together and integrated all regions.
33247359	0	29	theme	triphasic	29:37	arg1	scaffold					52:59	an integrated triphasic MBG-alginate scaffold	15:59	an integrated triphasic MBG-alginate scaffold	15:59	3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.
33247359	2	30	theme	promising	348:356	arg1	strategy					305:312	Tissue engineering strategy	286:312	Tissue engineering strategy	286:312	Tissue engineering strategy is currently regarded as the most promising way to repair osteochondral defects.
33247359	2	30	theme	promising	348:356	arg1	way					358:360	the most promising way	339:360	the most promising way to repair osteochondral defects	339:392	Tissue engineering strategy is currently regarded as the most promising way to repair osteochondral defects.
33247359	7	31	theme	SA	1049:1050	arg1	crosslinking					1052:1063	SA crosslinking	1049:1063	SA crosslinking after 3D printing	1049:1081	The results indicated that SA crosslinking after 3D printing anchored different materials together and integrated all regions.
33247359	8	32	theme	compressive	1279:1289	arg1	strengths					1303:1311	the compressive and tensile strengths	1275:1311	the compressive and tensile strengths	1275:1311	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	5	33	theme	porous	732:737	arg1	layer					744:748	a porous bone layer	730:748	a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG)	730:820	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	5	34	theme	intermediate	826:837	arg1	layer					845:849	an intermediate dense layer	823:849	an intermediate dense layer also composed of SA and MBG	823:877	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	0	35	theme	integrated	18:27	arg1	scaffold					52:59	an integrated triphasic MBG-alginate scaffold	15:59	an integrated triphasic MBG-alginate scaffold	15:59	3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.
33247359	1	36	from	parts	264:268	arg1	orthopedics					273:283	orthopedics	273:283	orthopedics	273:283	Osteochondral defects affect both of cartilage and subchondral areas, thus it poses a significant challenge to simultaneously regenerate two parts in orthopedics.
33247359	8	37	theme	Additional	1149:1158	arg1	soaking					1169:1175	Additional scaffold soaking	1149:1175	Additional scaffold soaking in simulated body fluid (SBF)	1149:1205	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	5	38	theme	cartilaginous	885:897	arg1	layer					899:903	a cartilaginous layer	883:903	a cartilaginous layer composed of SA	883:918	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	1	39	theme	significant	209:219	arg1	challenge					221:229	a significant challenge	207:229	a significant challenge to simultaneously regenerate two parts in orthopedics	207:283	Osteochondral defects affect both of cartilage and subchondral areas, thus it poses a significant challenge to simultaneously regenerate two parts in orthopedics.
33247359	0	40	theme	scaffold	52:59	arg1	printing					3:10	3D printing	0:10	3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.	0:121	3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.
33247359	5	41	theme	bone	739:742	arg1	layer					744:748	a porous bone layer	730:748	a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG)	730:820	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	3	42	with	scaffold	443:450	arg1	bonding					476:482	enhanced interface bonding	457:482	enhanced interface bonding	457:482	This study focuses on developing a multilayered scaffold with enhanced interface bonding through 3D printing.
33247359	3	43	theme	enhanced	457:464	arg1	bonding					476:482	enhanced interface bonding	457:482	enhanced interface bonding	457:482	This study focuses on developing a multilayered scaffold with enhanced interface bonding through 3D printing.
33247359	8	44	theme	tensile	1295:1301	arg1	strengths					1303:1311	the compressive and tensile strengths	1275:1311	the compressive and tensile strengths	1275:1311	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	0	45	theme	MBG-alginate	39:50	arg1	scaffold					52:59	an integrated triphasic MBG-alginate scaffold	15:59	an integrated triphasic MBG-alginate scaffold	15:59	3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.
33247359	0	46	with	printing	3:10	arg1	bonding					85:91	enhanced interface bonding	66:91	enhanced interface bonding for hard tissue applications	66:120	3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.
33247359	1	47	theme	Osteochondral	123:135	arg1	defects					137:143	Osteochondral defects	123:143	Osteochondral defects	123:143	Osteochondral defects affect both of cartilage and subchondral areas, thus it poses a significant challenge to simultaneously regenerate two parts in orthopedics.
33247359	4	48	theme	pore	574:577	arg1	structure					579:587	pore structure	574:587	pore structure	574:587	One-shot printing process enables control over material composition, pore structure, and size in each region of the scaffold, while realizes seamlessly integrated construct as well.
33247359	8	49	theme	body	1190:1193	arg1	SBF					1202:1204	SBF	1202:1204	SBF	1202:1204	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	8	49	theme	body	1190:1193	arg1	fluid					1195:1199	simulated body fluid	1180:1199	simulated body fluid (SBF)	1180:1205	Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.
33247359	4	50	theme	scaffold	621:628	arg1	region					607:612	each region	602:612	each region of the scaffold	602:628	One-shot printing process enables control over material composition, pore structure, and size in each region of the scaffold, while realizes seamlessly integrated construct as well.
33247359	0	51	theme	enhanced	66:73	arg1	bonding					85:91	enhanced interface bonding	66:91	enhanced interface bonding for hard tissue applications	66:120	3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.
33247359	5	52	theme	dense	839:843	arg1	layer					845:849	an intermediate dense layer	823:849	an intermediate dense layer also composed of SA and MBG	823:877	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	4	53	theme	integrated	657:666	arg1	construct					668:676	seamlessly integrated construct	646:676	seamlessly integrated construct	646:676	One-shot printing process enables control over material composition, pore structure, and size in each region of the scaffold, while realizes seamlessly integrated construct as well.
33247359	2	54	theme	repair	365:370	arg1	defects					386:392	repair osteochondral defects	365:392	repair osteochondral defects	365:392	Tissue engineering strategy is currently regarded as the most promising way to repair osteochondral defects.
33247359	5	55	theme	mesoporous	787:796	arg1	MBG					817:819	MBG	817:819	MBG	817:819	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	5	55	theme	mesoporous	787:796	arg1	glasses					808:814	mesoporous bioactive glasses	787:814	mesoporous bioactive glasses (MBG)	787:820	The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA.
33247359	3	56	theme	multilayered	430:441	arg1	scaffold					443:450	a multilayered scaffold	428:450	a multilayered scaffold with enhanced interface bonding	428:482	This study focuses on developing a multilayered scaffold with enhanced interface bonding through 3D printing.
33247359	2	57	theme	osteochondral	372:384	arg1	defects					386:392	repair osteochondral defects	365:392	repair osteochondral defects	365:392	Tissue engineering strategy is currently regarded as the most promising way to repair osteochondral defects.
34874163	0	0	theme	Selective	93:101	arg1	Oxidation					103:111	Selective Oxidation	93:111	Selective Oxidation	93:111	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation Used for Urethral Repair.
34874163	2	1	theme	double-modified	489:503	arg1	DMBC					526:529	DMBC	526:529	DMBC	526:529	Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC).
34874163	2	1	theme	double-modified	489:503	arg1	cellulose					515:523	the double-modified bacterial cellulose	485:523	the double-modified bacterial cellulose (DMBC)	485:530	Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC).
34874163	7	2	theme	new	948:950	arg1	DMBC/SPI					873:880	DMBC/SPI	873:880	DMBC/SPI	873:880	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	7	2	theme	new	948:950	arg1	material					976:983	a new urethral reconstruction material	946:983	a new urethral reconstruction material in clinical applications	946:1008	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	2	3	theme	Bacterial	365:373	arg1	BC					386:387	BC	386:387	BC	386:387	Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC).
34874163	2	3	theme	Bacterial	365:373	arg1	cellulose					375:383	Bacterial cellulose	365:383	Bacterial cellulose (BC)	365:388	Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC).
34874163	1	4	theme	urethral	242:249	arg1	scaffold					270:277	urethral tissue engineering scaffold	242:277	urethral tissue engineering scaffold	242:277	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	5	5	theme	damaged	759:765	arg1	urethra					767:773	the damaged urethra	755:773	the damaged urethra	755:773	The results showed that DMBC/SPI was beneficial to heal the damaged urethra and did not cause a milder inflammatory response.
34874163	1	6	theme	double-modified	156:170	arg1	type					234:237	a new type	228:237	a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth	228:348	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	6	theme	double-modified	156:170	arg1	DMBC/SPI					217:224	DMBC/SPI	217:224	DMBC/SPI	217:224	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	6	theme	double-modified	156:170	arg1	isolate					208:214	a double-modified bacterial cellulose/soybean protein isolate	154:214	a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI)	154:225	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	7	theme	tissue	251:256	arg1	scaffold					270:277	urethral tissue engineering scaffold	242:277	urethral tissue engineering scaffold	242:277	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	7	8	contain	has	882:884	arg1	DMBC/SPI					873:880	DMBC/SPI	873:880	DMBC/SPI	873:880	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	7	8	contain	has	882:884	arg2	effect					909:914	a good urethral repair effect	886:914	a good urethral repair effect	886:914	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	7	8	contain	has	882:884	arg1	material					976:983	a new urethral reconstruction material	946:983	a new urethral reconstruction material in clinical applications	946:1008	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	3	9	theme	protein	545:551	arg1	SPI					562:564	SPI	562:564	SPI	562:564	The soybean protein isolate (SPI) was compounded on DMBC to obtain DMBC/SPI with better biocompatibility.
34874163	3	9	theme	protein	545:551	arg1	isolate					553:559	The soybean protein isolate	533:559	The soybean protein isolate (SPI)	533:565	The soybean protein isolate (SPI) was compounded on DMBC to obtain DMBC/SPI with better biocompatibility.
34874163	1	10	theme	engineering	258:268	arg1	scaffold					270:277	urethral tissue engineering scaffold	242:277	urethral tissue engineering scaffold	242:277	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	7	11	theme	urethral	952:959	arg1	DMBC/SPI					873:880	DMBC/SPI	873:880	DMBC/SPI	873:880	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	7	11	theme	urethral	952:959	arg1	material					976:983	a new urethral reconstruction material	946:983	a new urethral reconstruction material in clinical applications	946:1008	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	1	12	theme	scaffold	270:277	arg1	type					234:237	a new type	228:237	a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth	228:348	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	12	theme	scaffold	270:277	arg1	isolate					208:214	a double-modified bacterial cellulose/soybean protein isolate	154:214	a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI)	154:225	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	0	13	theme	Urethral	122:129	arg1	Repair					131:136	Urethral Repair	122:136	Urethral Repair	122:136	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation Used for Urethral Repair.
34874163	4	14	from	repair	660:665	arg1	rabbits					690:696	rabbits	690:696	rabbits	690:696	DMBC/SPI was used to repair the damaged urethra in rabbits.
34874163	1	15	theme	bacterial	172:180	arg1	type					234:237	a new type	228:237	a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth	228:348	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	15	theme	bacterial	172:180	arg1	DMBC/SPI					217:224	DMBC/SPI	217:224	DMBC/SPI	217:224	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	15	theme	bacterial	172:180	arg1	isolate					208:214	a double-modified bacterial cellulose/soybean protein isolate	154:214	a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI)	154:225	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	8	16	theme	composites	1203:1212	arg1	properties					1180:1189	the properties	1176:1189	the properties of DMBC/SPI composites	1176:1212	In addition, FT-IR spectroscopy, SEM, static contact angle measurements, mechanical property investigation, and cell experiments were also performed to characterize the properties of DMBC/SPI composites.
34874163	8	17	theme	FT-IR	1024:1028	arg1	spectroscopy					1030:1041	FT-IR spectroscopy	1024:1041	FT-IR spectroscopy	1024:1041	In addition, FT-IR spectroscopy, SEM, static contact angle measurements, mechanical property investigation, and cell experiments were also performed to characterize the properties of DMBC/SPI composites.
34874163	2	18	theme	forming	443:449	arg1	hole					438:441	laser hole forming	432:449	laser hole forming	432:449	Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC).
34874163	1	19	theme	cellulose/soybean	182:198	arg1	type					234:237	a new type	228:237	a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth	228:348	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	19	theme	cellulose/soybean	182:198	arg1	DMBC/SPI					217:224	DMBC/SPI	217:224	DMBC/SPI	217:224	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	19	theme	cellulose/soybean	182:198	arg1	isolate					208:214	a double-modified bacterial cellulose/soybean protein isolate	154:214	a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI)	154:225	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	0	20	theme	Bacterial	16:24	arg1	Composites					56:65	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites	0:65	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation	0:111	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation Used for Urethral Repair.
34874163	7	21	used	used	938:941	arg2	material					976:983	a new urethral reconstruction material	946:983	a new urethral reconstruction material in clinical applications	946:1008	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	7	21	used	used	938:941	arg2	DMBC/SPI					873:880	DMBC/SPI	873:880	DMBC/SPI	873:880	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	1	22	theme	protein	200:206	arg1	type					234:237	a new type	228:237	a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth	228:348	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	22	theme	protein	200:206	arg1	DMBC/SPI					217:224	DMBC/SPI	217:224	DMBC/SPI	217:224	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	22	theme	protein	200:206	arg1	isolate					208:214	a double-modified bacterial cellulose/soybean protein isolate	154:214	a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI)	154:225	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	0	23	theme	Double-Modified	0:14	arg1	Composites					56:65	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites	0:65	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation	0:111	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation Used for Urethral Repair.
34874163	8	24	theme	cell	1123:1126	arg1	experiments					1128:1138	cell experiments	1123:1138	cell experiments	1123:1138	In addition, FT-IR spectroscopy, SEM, static contact angle measurements, mechanical property investigation, and cell experiments were also performed to characterize the properties of DMBC/SPI composites.
34874163	0	25	theme	Protein	40:46	arg1	Composites					56:65	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites	0:65	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation	0:111	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation Used for Urethral Repair.
34874163	1	26	theme	good	284:287	arg1	biocompatibility					289:304	good biocompatibility	284:304	good biocompatibility	284:304	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	8	27	theme	static	1049:1054	arg1	measurements					1070:1081	static contact angle measurements	1049:1081	static contact angle measurements	1049:1081	In addition, FT-IR spectroscopy, SEM, static contact angle measurements, mechanical property investigation, and cell experiments were also performed to characterize the properties of DMBC/SPI composites.
34874163	7	28	from	material	976:983	arg1	applications					997:1008	clinical applications	988:1008	clinical applications	988:1008	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	0	29	theme	Cellulose/Soy	26:38	arg1	Composites					56:65	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites	0:65	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation	0:111	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation Used for Urethral Repair.
34874163	2	30	mod	modified	420:427	arg1	BC					386:387	BC	386:387	BC	386:387	Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC).
34874163	2	30	mod	modified	420:427	arg3	hole					438:441	laser hole forming	432:449	laser hole forming	432:449	Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC).
34874163	2	30	mod	modified	420:427	arg1	cellulose					375:383	Bacterial cellulose	365:383	Bacterial cellulose (BC)	365:388	Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC).
34874163	2	30	mod	modified	420:427	arg3	oxidation					465:473	selective oxidation	455:473	selective oxidation to obtain the double-modified bacterial cellulose (DMBC)	455:530	Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC).
34874163	8	31	theme	DMBC/SPI	1194:1201	arg1	composites					1203:1212	DMBC/SPI composites	1194:1212	DMBC/SPI composites	1194:1212	In addition, FT-IR spectroscopy, SEM, static contact angle measurements, mechanical property investigation, and cell experiments were also performed to characterize the properties of DMBC/SPI composites.
34874163	8	32	theme	angle	1064:1068	arg1	measurements					1070:1081	static contact angle measurements	1049:1081	static contact angle measurements	1049:1081	In addition, FT-IR spectroscopy, SEM, static contact angle measurements, mechanical property investigation, and cell experiments were also performed to characterize the properties of DMBC/SPI composites.
34874163	0	33	theme	Isolate	48:54	arg1	Composites					56:65	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites	0:65	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation	0:111	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation Used for Urethral Repair.
34874163	8	34	theme	contact	1056:1062	arg1	measurements					1070:1081	static contact angle measurements	1049:1081	static contact angle measurements	1049:1081	In addition, FT-IR spectroscopy, SEM, static contact angle measurements, mechanical property investigation, and cell experiments were also performed to characterize the properties of DMBC/SPI composites.
34874163	5	35	theme	milder	795:800	arg1	response					815:822	a milder inflammatory response	793:822	a milder inflammatory response	793:822	The results showed that DMBC/SPI was beneficial to heal the damaged urethra and did not cause a milder inflammatory response.
34874163	7	36	theme	clinical	988:995	arg1	applications					997:1008	clinical applications	988:1008	clinical applications	988:1008	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	0	37	theme	Laser	70:74	arg1	Hole					76:79	Laser Hole Forming	70:87	Laser Hole Forming	70:87	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation Used for Urethral Repair.
34874163	5	38	theme	inflammatory	802:813	arg1	response					815:822	a milder inflammatory response	793:822	a milder inflammatory response	793:822	The results showed that DMBC/SPI was beneficial to heal the damaged urethra and did not cause a milder inflammatory response.
34874163	3	39	with	DMBC/SPI	600:607	arg1	biocompatibility					621:636	better biocompatibility	614:636	better biocompatibility	614:636	The soybean protein isolate (SPI) was compounded on DMBC to obtain DMBC/SPI with better biocompatibility.
34874163	2	40	theme	selective	455:463	arg1	oxidation					465:473	selective oxidation	455:473	selective oxidation to obtain the double-modified bacterial cellulose (DMBC)	455:530	Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC).
34874163	6	41	theme	repaired	829:836	arg1	smooth					850:855	smooth	850:855	smooth	850:855	The repaired urethra was smooth and continuous.
34874163	6	41	theme	repaired	829:836	arg1	urethra					838:844	The repaired urethra	825:844	The repaired urethra	825:844	The repaired urethra was smooth and continuous.
34874163	4	42	used	used	652:655	arg2	DMBC/SPI					639:646	DMBC/SPI	639:646	DMBC/SPI	639:646	DMBC/SPI was used to repair the damaged urethra in rabbits.
34874163	7	43	theme	urethral	893:900	arg1	effect					909:914	a good urethral repair effect	886:914	a good urethral repair effect	886:914	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	1	44	theme	cell-oriented	329:341	arg1	growth					343:348	cell-oriented growth	329:348	cell-oriented growth	329:348	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	8	45	theme	property	1095:1102	arg1	investigation					1104:1116	mechanical property investigation	1084:1116	mechanical property investigation	1084:1116	In addition, FT-IR spectroscopy, SEM, static contact angle measurements, mechanical property investigation, and cell experiments were also performed to characterize the properties of DMBC/SPI composites.
34874163	8	46	theme	mechanical	1084:1093	arg1	investigation					1104:1116	mechanical property investigation	1084:1116	mechanical property investigation	1084:1116	In addition, FT-IR spectroscopy, SEM, static contact angle measurements, mechanical property investigation, and cell experiments were also performed to characterize the properties of DMBC/SPI composites.
34874163	7	47	theme	repair	902:907	arg1	effect					909:914	a good urethral repair effect	886:914	a good urethral repair effect	886:914	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	3	48	theme	soybean	537:543	arg1	SPI					562:564	SPI	562:564	SPI	562:564	The soybean protein isolate (SPI) was compounded on DMBC to obtain DMBC/SPI with better biocompatibility.
34874163	3	48	theme	soybean	537:543	arg1	isolate					553:559	The soybean protein isolate	533:559	The soybean protein isolate (SPI)	533:565	The soybean protein isolate (SPI) was compounded on DMBC to obtain DMBC/SPI with better biocompatibility.
34874163	3	49	theme	better	614:619	arg1	biocompatibility					621:636	better biocompatibility	614:636	better biocompatibility	614:636	The soybean protein isolate (SPI) was compounded on DMBC to obtain DMBC/SPI with better biocompatibility.
34874163	1	50	with	type	234:237	arg1	biocompatibility					289:304	good biocompatibility	284:304	good biocompatibility	284:304	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	50	with	type	234:237	arg1	growth					343:348	cell-oriented growth	329:348	cell-oriented growth	329:348	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	50	with	type	234:237	arg1	biodegradability					307:322	biodegradability	307:322	biodegradability	307:322	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	51	theme	new	230:232	arg1	type					234:237	a new type	228:237	a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth	228:348	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	1	51	theme	new	230:232	arg1	isolate					208:214	a double-modified bacterial cellulose/soybean protein isolate	154:214	a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI)	154:225	In this study, a double-modified bacterial cellulose/soybean protein isolate (DMBC/SPI), a new type of urethral tissue engineering scaffold with good biocompatibility, biodegradability, and cell-oriented growth, was prepared.
34874163	0	52	theme	Forming	81:87	arg1	Hole					76:79	Laser Hole Forming	70:87	Laser Hole Forming	70:87	Double-Modified Bacterial Cellulose/Soy Protein Isolate Composites by Laser Hole Forming and Selective Oxidation Used for Urethral Repair.
34874163	7	53	theme	reconstruction	961:974	arg1	DMBC/SPI					873:880	DMBC/SPI	873:880	DMBC/SPI	873:880	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	7	53	theme	reconstruction	961:974	arg1	material					976:983	a new urethral reconstruction material	946:983	a new urethral reconstruction material in clinical applications	946:1008	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	7	54	theme	good	888:891	arg1	effect					909:914	a good urethral repair effect	886:914	a good urethral repair effect	886:914	DMBC/SPI has a good urethral repair effect and is expected to be used as a new urethral reconstruction material in clinical applications.
34874163	2	55	theme	bacterial	505:513	arg1	DMBC					526:529	DMBC	526:529	DMBC	526:529	Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC).
34874163	2	55	theme	bacterial	505:513	arg1	cellulose					515:523	the double-modified bacterial cellulose	485:523	the double-modified bacterial cellulose (DMBC)	485:530	Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC).
34874163	2	56	theme	laser	432:436	arg1	hole					438:441	laser hole forming	432:449	laser hole forming	432:449	Bacterial cellulose (BC) was physically and chemically modified by laser hole forming and selective oxidation to obtain the double-modified bacterial cellulose (DMBC).
34874163	4	57	theme	damaged	671:677	arg1	urethra					679:685	the damaged urethra	667:685	the damaged urethra	667:685	DMBC/SPI was used to repair the damaged urethra in rabbits.
33803244	7	0	theme	better	1157:1162	arg1	stability					1175:1183	better suspension stability	1157:1183	better suspension stability	1157:1183	Moreover, the sedimentation stability of composite improves drastically, which means better suspension stability.
33803244	4	1	from	cellulose	743:751	arg1	different					719:727	different	719:727	different	719:727	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	1	from	cellulose	743:751	arg1	particles					697:705	the composite particles	683:705	the composite particles	683:705	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	7	2	theme	suspension	1164:1173	arg1	stability					1175:1183	better suspension stability	1157:1183	better suspension stability	1157:1183	Moreover, the sedimentation stability of composite improves drastically, which means better suspension stability.
33803244	6	3	theme	composite	1032:1040	arg1	particles					1042:1050	the composite particles	1028:1050	the composite particles with rough surface	1028:1069	It was found that the ER properties of the composite were more superior to those of raw cellulose due to the flake-like shapes of the composite particles with rough surface.
33803244	2	4	theme	electrorheological	330:347	arg1	material					354:361	an electrorheological (ER) material	327:361	an electrorheological (ER) material	327:361	In this work, cellulose micron particles were applied as an electrorheological (ER) material.
33803244	2	4	theme	electrorheological	330:347	arg1	particles					301:309	cellulose micron particles	284:309	cellulose micron particles	284:309	In this work, cellulose micron particles were applied as an electrorheological (ER) material.
33803244	6	5	theme	composite	941:949	arg1	superior					961:968	superior	961:968	superior	961:968	It was found that the ER properties of the composite were more superior to those of raw cellulose due to the flake-like shapes of the composite particles with rough surface.
33803244	6	5	theme	composite	941:949	arg1	properties					923:932	the ER properties	916:932	the ER properties of the composite	916:949	It was found that the ER properties of the composite were more superior to those of raw cellulose due to the flake-like shapes of the composite particles with rough surface.
33803244	4	6	dep	morphologies	652:663	arg1	the					648:650	the	648:650	the	648:650	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	7	theme	infrared	569:576	arg1	FT-IR					592:596	FT-IR	592:596	FT-IR	592:596	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	7	theme	infrared	569:576	arg1	spectroscopy					578:589	Fourier-transform infrared spectroscopy	551:589	Fourier-transform infrared spectroscopy (FT-IR)	551:597	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	8	from	Laponite	757:764	arg1	different					719:727	different	719:727	different	719:727	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	8	from	Laponite	757:764	arg1	particles					697:705	the composite particles	683:705	the composite particles	683:705	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	3	9	theme	cellulose	439:447	arg1	particle					427:434	a composite particle	415:434	a composite particle of cellulose and Laponite	415:460	Because of the low ER effect of the raw cellulose, a composite particle of cellulose and Laponite was prepared via a dissolution-regeneration process.
33803244	4	10	theme	composite	687:695	arg1	different					719:727	different	719:727	different	719:727	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	10	theme	composite	687:695	arg1	particles					697:705	the composite particles	683:705	the composite particles	683:705	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	3	11	theme	dissolution-regeneration	481:504	arg1	process					506:512	a dissolution-regeneration process	479:512	a dissolution-regeneration process	479:512	Because of the low ER effect of the raw cellulose, a composite particle of cellulose and Laponite was prepared via a dissolution-regeneration process.
33803244	3	12	theme	raw	400:402	arg1	cellulose					404:412	the raw cellulose	396:412	the raw cellulose	396:412	Because of the low ER effect of the raw cellulose, a composite particle of cellulose and Laponite was prepared via a dissolution-regeneration process.
33803244	4	13	theme	Fourier-transform	551:567	arg1	FT-IR					592:596	FT-IR	592:596	FT-IR	592:596	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	13	theme	Fourier-transform	551:567	arg1	spectroscopy					578:589	Fourier-transform infrared spectroscopy	551:589	Fourier-transform infrared spectroscopy (FT-IR)	551:597	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	6	14	with	particles	1042:1050	arg1	surface					1063:1069	rough surface	1057:1069	rough surface	1057:1069	It was found that the ER properties of the composite were more superior to those of raw cellulose due to the flake-like shapes of the composite particles with rough surface.
33803244	6	15	theme	rough	1057:1061	arg1	surface					1063:1069	rough surface	1057:1069	rough surface	1057:1069	It was found that the ER properties of the composite were more superior to those of raw cellulose due to the flake-like shapes of the composite particles with rough surface.
33803244	3	16	theme	cellulose	404:412	arg1	effect					386:391	the low ER effect	375:391	the low ER effect of the raw cellulose	375:412	Because of the low ER effect of the raw cellulose, a composite particle of cellulose and Laponite was prepared via a dissolution-regeneration process.
33803244	7	17	theme	composite	1113:1121	arg1	stability					1100:1108	the sedimentation stability	1082:1108	the sedimentation stability of composite	1082:1121	Moreover, the sedimentation stability of composite improves drastically, which means better suspension stability.
33803244	1	18	with	polymer	127:133	arg1	source					152:157	an abundant source	140:157	an abundant source	140:157	Cellulose, as a natural polymer with an abundant source, has been widely used in many fields including the electric field responsive medium that we are interested in.
33803244	4	19	theme	particles	697:705	arg1	structures					669:678	structures	669:678	structures	669:678	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	19	theme	particles	697:705	arg1	morphologies					652:663	morphologies	652:663	morphologies	652:663	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	5	20	theme	prepared	826:833	arg1	composite					835:843	the prepared composite	822:843	the prepared composite	822:843	The ER performances of raw cellulose and the prepared composite were measured by an Anton Paar rotational rheometer.
33803244	2	21	theme	micron	294:299	arg1	material					354:361	an electrorheological (ER) material	327:361	an electrorheological (ER) material	327:361	In this work, cellulose micron particles were applied as an electrorheological (ER) material.
33803244	2	21	theme	micron	294:299	arg1	particles					301:309	cellulose micron particles	284:309	cellulose micron particles	284:309	In this work, cellulose micron particles were applied as an electrorheological (ER) material.
33803244	1	22	theme	many	184:187	arg1	medium					236:241	the electric field responsive medium	206:241	the electric field responsive medium	206:241	Cellulose, as a natural polymer with an abundant source, has been widely used in many fields including the electric field responsive medium that we are interested in.
33803244	1	22	theme	many	184:187	arg1	fields					189:194	many fields	184:194	many fields including the electric field responsive medium	184:241	Cellulose, as a natural polymer with an abundant source, has been widely used in many fields including the electric field responsive medium that we are interested in.
33803244	0	23	theme	Composite	34:42	arg1	Particles					44:52	Cellulose/Laponite Composite Particles	15:52	Cellulose/Laponite Composite Particles	15:52	Preparation of Cellulose/Laponite Composite Particles and Their Enhanced Electrorheological Responses.
33803244	4	24	theme	electron	524:531	arg1	microscopy					533:542	Scanning electron microscopy	515:542	Scanning electron microscopy (SEM)	515:548	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	24	theme	electron	524:531	arg1	SEM					545:547	SEM	545:547	SEM	545:547	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	2	25	theme	cellulose	284:292	arg1	material					354:361	an electrorheological (ER) material	327:361	an electrorheological (ER) material	327:361	In this work, cellulose micron particles were applied as an electrorheological (ER) material.
33803244	2	25	theme	cellulose	284:292	arg1	particles					301:309	cellulose micron particles	284:309	cellulose micron particles	284:309	In this work, cellulose micron particles were applied as an electrorheological (ER) material.
33803244	3	26	theme	composite	417:425	arg1	particle					427:434	a composite particle	415:434	a composite particle of cellulose and Laponite	415:460	Because of the low ER effect of the raw cellulose, a composite particle of cellulose and Laponite was prepared via a dissolution-regeneration process.
33803244	0	27	theme	Cellulose/Laponite	15:32	arg1	Particles					44:52	Cellulose/Laponite Composite Particles	15:52	Cellulose/Laponite Composite Particles	15:52	Preparation of Cellulose/Laponite Composite Particles and Their Enhanced Electrorheological Responses.
33803244	4	28	theme	pristine	734:741	arg1	cellulose					743:751	pristine cellulose	734:751	pristine cellulose	734:751	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	1	29	theme	natural	119:125	arg1	polymer					127:133	as a natural polymer	114:133	as a natural polymer with an abundant source	114:157	Cellulose, as a natural polymer with an abundant source, has been widely used in many fields including the electric field responsive medium that we are interested in.
33803244	1	29	theme	natural	119:125	arg1	Cellulose					103:111	Cellulose	103:111	Cellulose	103:111	Cellulose, as a natural polymer with an abundant source, has been widely used in many fields including the electric field responsive medium that we are interested in.
33803244	3	30	theme	ER	383:384	arg1	effect					386:391	the low ER effect	375:391	the low ER effect of the raw cellulose	375:412	Because of the low ER effect of the raw cellulose, a composite particle of cellulose and Laponite was prepared via a dissolution-regeneration process.
33803244	5	31	theme	Paar	871:874	arg1	rheometer					887:895	an Anton Paar rotational rheometer	862:895	an Anton Paar rotational rheometer	862:895	The ER performances of raw cellulose and the prepared composite were measured by an Anton Paar rotational rheometer.
33803244	5	32	theme	composite	835:843	arg1	performances					788:799	The ER performances	781:799	The ER performances of raw cellulose and the prepared composite	781:843	The ER performances of raw cellulose and the prepared composite were measured by an Anton Paar rotational rheometer.
33803244	5	33	theme	raw	804:806	arg1	cellulose					808:816	raw cellulose	804:816	raw cellulose	804:816	The ER performances of raw cellulose and the prepared composite were measured by an Anton Paar rotational rheometer.
33803244	0	34	theme	Particles	44:52	arg1	Preparation					0:10	Preparation	0:10	Preparation of Cellulose/Laponite Composite Particles	0:52	Preparation of Cellulose/Laponite Composite Particles and Their Enhanced Electrorheological Responses.
33803244	0	34	theme	Particles	44:52	arg1	Responses					92:100	Their Enhanced Electrorheological Responses	58:100	Their Enhanced Electrorheological Responses	58:100	Preparation of Cellulose/Laponite Composite Particles and Their Enhanced Electrorheological Responses.
33803244	7	35	theme	sedimentation	1086:1098	arg1	stability					1100:1108	the sedimentation stability	1082:1108	the sedimentation stability of composite	1082:1121	Moreover, the sedimentation stability of composite improves drastically, which means better suspension stability.
33803244	1	36	theme	electric	210:217	arg1	field					219:223	the electric field	206:223	the electric field responsive medium	206:241	Cellulose, as a natural polymer with an abundant source, has been widely used in many fields including the electric field responsive medium that we are interested in.
33803244	0	37	theme	Enhanced	64:71	arg1	Responses					92:100	Their Enhanced Electrorheological Responses	58:100	Their Enhanced Electrorheological Responses	58:100	Preparation of Cellulose/Laponite Composite Particles and Their Enhanced Electrorheological Responses.
33803244	6	38	theme	ER	920:921	arg1	superior					961:968	superior	961:968	superior	961:968	It was found that the ER properties of the composite were more superior to those of raw cellulose due to the flake-like shapes of the composite particles with rough surface.
33803244	6	38	theme	ER	920:921	arg1	properties					923:932	the ER properties	916:932	the ER properties of the composite	916:949	It was found that the ER properties of the composite were more superior to those of raw cellulose due to the flake-like shapes of the composite particles with rough surface.
33803244	4	39	used	used	632:635	arg2	FT-IR					592:596	FT-IR	592:596	FT-IR	592:596	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	39	used	used	632:635	arg2	XRD					622:624	XRD	622:624	XRD	622:624	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	39	used	used	632:635	arg2	microscopy					533:542	Scanning electron microscopy	515:542	Scanning electron microscopy (SEM)	515:548	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	39	used	used	632:635	arg2	SEM					545:547	SEM	545:547	SEM	545:547	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	39	used	used	632:635	arg2	spectroscopy					578:589	Fourier-transform infrared spectroscopy	551:589	Fourier-transform infrared spectroscopy (FT-IR)	551:597	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	39	used	used	632:635	arg2	diffraction					609:619	X-ray diffraction	603:619	X-ray diffraction (XRD)	603:625	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	5	40	theme	Anton	865:869	arg1	rheometer					887:895	an Anton Paar rotational rheometer	862:895	an Anton Paar rotational rheometer	862:895	The ER performances of raw cellulose and the prepared composite were measured by an Anton Paar rotational rheometer.
33803244	3	41	theme	low	379:381	arg1	effect					386:391	the low ER effect	375:391	the low ER effect of the raw cellulose	375:412	Because of the low ER effect of the raw cellulose, a composite particle of cellulose and Laponite was prepared via a dissolution-regeneration process.
33803244	4	42	theme	Scanning	515:522	arg1	microscopy					533:542	Scanning electron microscopy	515:542	Scanning electron microscopy (SEM)	515:548	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	42	theme	Scanning	515:522	arg1	SEM					545:547	SEM	545:547	SEM	545:547	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	3	43	theme	Laponite	453:460	arg1	particle					427:434	a composite particle	415:434	a composite particle of cellulose and Laponite	415:460	Because of the low ER effect of the raw cellulose, a composite particle of cellulose and Laponite was prepared via a dissolution-regeneration process.
33803244	5	44	theme	rotational	876:885	arg1	rheometer					887:895	an Anton Paar rotational rheometer	862:895	an Anton Paar rotational rheometer	862:895	The ER performances of raw cellulose and the prepared composite were measured by an Anton Paar rotational rheometer.
33803244	1	45	theme	field	219:223	arg1	medium					236:241	the electric field responsive medium	206:241	the electric field responsive medium	206:241	Cellulose, as a natural polymer with an abundant source, has been widely used in many fields including the electric field responsive medium that we are interested in.
33803244	1	46	theme	abundant	143:150	arg1	source					152:157	an abundant source	140:157	an abundant source	140:157	Cellulose, as a natural polymer with an abundant source, has been widely used in many fields including the electric field responsive medium that we are interested in.
33803244	1	47	theme	responsive	225:234	arg1	medium					236:241	the electric field responsive medium	206:241	the electric field responsive medium	206:241	Cellulose, as a natural polymer with an abundant source, has been widely used in many fields including the electric field responsive medium that we are interested in.
33803244	5	48	theme	cellulose	808:816	arg1	performances					788:799	The ER performances	781:799	The ER performances of raw cellulose and the prepared composite	781:843	The ER performances of raw cellulose and the prepared composite were measured by an Anton Paar rotational rheometer.
33803244	1	49	used	used	176:179	arg2	polymer					127:133	as a natural polymer	114:133	as a natural polymer with an abundant source	114:157	Cellulose, as a natural polymer with an abundant source, has been widely used in many fields including the electric field responsive medium that we are interested in.
33803244	1	49	used	used	176:179	arg2	Cellulose					103:111	Cellulose	103:111	Cellulose	103:111	Cellulose, as a natural polymer with an abundant source, has been widely used in many fields including the electric field responsive medium that we are interested in.
33803244	4	50	theme	X-ray	603:607	arg1	diffraction					609:619	X-ray diffraction	603:619	X-ray diffraction (XRD)	603:625	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	4	50	theme	X-ray	603:607	arg1	XRD					622:624	XRD	622:624	XRD	622:624	Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to observe the morphologies and structures of the composite particles, which were different from pristine cellulose and Laponite, respectively.
33803244	6	51	theme	particles	1042:1050	arg1	shapes					1018:1023	the flake-like shapes	1003:1023	the flake-like shapes of the composite particles with rough surface	1003:1069	It was found that the ER properties of the composite were more superior to those of raw cellulose due to the flake-like shapes of the composite particles with rough surface.
33803244	6	52	theme	flake-like	1007:1016	arg1	shapes					1018:1023	the flake-like shapes	1003:1023	the flake-like shapes of the composite particles with rough surface	1003:1069	It was found that the ER properties of the composite were more superior to those of raw cellulose due to the flake-like shapes of the composite particles with rough surface.
33803244	0	53	theme	Electrorheological	73:90	arg1	Responses					92:100	Their Enhanced Electrorheological Responses	58:100	Their Enhanced Electrorheological Responses	58:100	Preparation of Cellulose/Laponite Composite Particles and Their Enhanced Electrorheological Responses.
33803244	5	54	theme	ER	785:786	arg1	performances					788:799	The ER performances	781:799	The ER performances of raw cellulose and the prepared composite	781:843	The ER performances of raw cellulose and the prepared composite were measured by an Anton Paar rotational rheometer.
33803244	2	55	theme	ER	350:351	arg1	material					354:361	an electrorheological (ER) material	327:361	an electrorheological (ER) material	327:361	In this work, cellulose micron particles were applied as an electrorheological (ER) material.
33803244	2	55	theme	ER	350:351	arg1	particles					301:309	cellulose micron particles	284:309	cellulose micron particles	284:309	In this work, cellulose micron particles were applied as an electrorheological (ER) material.
32252261	4	0	dep	type	716:719	arg1	the					709:711	the	709:711	the	709:711	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	6	1	theme	flame	1057:1061	arg1	retardancy					1063:1072	the flame retardancy	1053:1072	the flame retardancy of regenerated cellulose	1053:1097	Significant improvement in the flame retardancy of regenerated cellulose was obtained with a reduction of THR values down to about 5-6 kJ/g and an increase of char up to about 35 wt%.
32252261	1	2	theme	H	278:278	arg1	PO2					280:282	(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM	272:338	PO2	280:282	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	5	3	theme	fire	904:907	arg1	performances					909:920	the microscale fire performances	889:920	the microscale fire performances of modified cellulose	889:942	The rheological behavior of cotton cellulose/ILs solutions and the microscale fire performances of modified cellulose were studied in order to ultimately prepare flame retardant cellulosic materials.
32252261	1	4	theme	H	347:347	arg1	[DIMIM					264:269	1,3-dimethylimidazolium methylphosphonate [DIMIM	222:269	phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2]	183:352	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	1	4	theme	H	347:347	arg1	PO2					349:351	(MeO)(H)PO2	341:351	(MeO)(H)PO2	341:351	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	6	5	theme	values	1136:1141	arg1	reduction					1119:1127	a reduction	1117:1127	a reduction of THR values down to about 5-6 kJ/g	1117:1164	Significant improvement in the flame retardancy of regenerated cellulose was obtained with a reduction of THR values down to about 5-6 kJ/g and an increase of char up to about 35 wt%.
32252261	6	5	theme	values	1136:1141	arg1	increase					1173:1180	an increase	1170:1180	an increase of char up to about 35 wt%	1170:1207	Significant improvement in the flame retardancy of regenerated cellulose was obtained with a reduction of THR values down to about 5-6 kJ/g and an increase of char up to about 35 wt%.
32252261	5	6	theme	modified	925:932	arg1	cellulose					934:942	modified cellulose	925:942	modified cellulose	925:942	The rheological behavior of cotton cellulose/ILs solutions and the microscale fire performances of modified cellulose were studied in order to ultimately prepare flame retardant cellulosic materials.
32252261	6	7	from	improvement	1038:1048	arg1	retardancy					1063:1072	the flame retardancy	1053:1072	the flame retardancy of regenerated cellulose	1053:1097	Significant improvement in the flame retardancy of regenerated cellulose was obtained with a reduction of THR values down to about 5-6 kJ/g and an increase of char up to about 35 wt%.
32252261	6	8	theme	wt	1205:1206	arg1	%					1207:1207	about 35 wt%	1196:1207	about 35 wt%	1196:1207	Significant improvement in the flame retardancy of regenerated cellulose was obtained with a reduction of THR values down to about 5-6 kJ/g and an increase of char up to about 35 wt%.
32252261	3	9	theme	cellulose	551:559	arg1	structure					561:569	The resulting cellulose structure	537:569	The resulting cellulose structure	537:569	The resulting cellulose structure and the amount of grafted phosphorus were then investigated by X-ray diffraction, ICP-AES, and ¹³C and ³¹P NMR spectroscopy.
32252261	2	10	theme	cellulose	526:534	arg1	functions					513:521	the primary alcohol functions	493:521	the primary alcohol functions of cellulose	493:534	The chemical modification of cellulose occurred through a transesterification reaction between the methyl phosphonate function of ILs and the primary alcohol functions of cellulose.
32252261	2	10	theme	cellulose	526:534	arg1	ILs					485:487	ILs	485:487	ILs	485:487	The chemical modification of cellulose occurred through a transesterification reaction between the methyl phosphonate function of ILs and the primary alcohol functions of cellulose.
32252261	4	11	theme	regenerated	768:778	arg1	cellulose					780:788	regenerated cellulose	768:788	regenerated cellulose	768:788	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	5	12	theme	microscale	893:902	arg1	performances					909:920	the microscale fire performances	889:920	the microscale fire performances of modified cellulose	889:942	The rheological behavior of cotton cellulose/ILs solutions and the microscale fire performances of modified cellulose were studied in order to ultimately prepare flame retardant cellulosic materials.
32252261	4	13	theme	phosphorus	814:823	arg1	phosphorus					814:823	phosphorus	814:823	phosphorus	814:823	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	4	13	theme	phosphorus	814:823	arg1	%					809:809	up to 4.5%	800:809	up to 4.5% of phosphorus	800:823	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	4	14	theme	cotton	733:738	arg1	ratio					745:749	initial cotton / IL ratio	725:749	initial cotton / IL ratio	725:749	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	2	15	theme	cellulose	384:392	arg1	modification					368:379	The chemical modification	355:379	The chemical modification of cellulose	355:392	The chemical modification of cellulose occurred through a transesterification reaction between the methyl phosphonate function of ILs and the primary alcohol functions of cellulose.
32252261	2	16	theme	phosphonate	461:471	arg1	function					473:480	the methyl phosphonate function	450:480	the methyl phosphonate function of ILs and the primary alcohol functions of cellulose	450:534	The chemical modification of cellulose occurred through a transesterification reaction between the methyl phosphonate function of ILs and the primary alcohol functions of cellulose.
32252261	2	17	theme	ILs	485:487	arg1	function					473:480	the methyl phosphonate function	450:480	the methyl phosphonate function of ILs and the primary alcohol functions of cellulose	450:534	The chemical modification of cellulose occurred through a transesterification reaction between the methyl phosphonate function of ILs and the primary alcohol functions of cellulose.
32252261	1	18	theme	cotton	102:107	arg1	fibers					109:114	cotton fibers	102:114	cotton fibers	102:114	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	6	19	theme	cellulose	1089:1097	arg1	retardancy					1063:1072	the flame retardancy	1053:1072	the flame retardancy of regenerated cellulose	1053:1097	Significant improvement in the flame retardancy of regenerated cellulose was obtained with a reduction of THR values down to about 5-6 kJ/g and an increase of char up to about 35 wt%.
32252261	0	20	theme	Retardant-Functionalized	6:29	arg1	Cellulose					38:46	Flame Retardant-Functionalized Cotton Cellulose	0:46	Flame Retardant-Functionalized Cotton Cellulose	0:46	Flame Retardant-Functionalized Cotton Cellulose Using Phosphonate-Based Ionic Liquids.
32252261	1	21	dep	liquids	207:213	arg1	[DIMIM					264:269	1,3-dimethylimidazolium methylphosphonate [DIMIM	222:269	phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2]	183:352	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	1	21	dep	liquids	207:213	arg1	PO2					349:351	(MeO)(H)PO2	341:351	(MeO)(H)PO2	341:351	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	6	22	theme	regenerated	1077:1087	arg1	cellulose					1089:1097	regenerated cellulose	1077:1097	regenerated cellulose	1077:1097	Significant improvement in the flame retardancy of regenerated cellulose was obtained with a reduction of THR values down to about 5-6 kJ/g and an increase of char up to about 35 wt%.
32252261	0	23	theme	Flame	0:4	arg1	Cellulose					38:46	Flame Retardant-Functionalized Cotton Cellulose	0:46	Flame Retardant-Functionalized Cotton Cellulose	0:46	Flame Retardant-Functionalized Cotton Cellulose Using Phosphonate-Based Ionic Liquids.
32252261	6	24	theme	down	1143:1146	arg1	values					1136:1141	THR values	1132:1141	THR values down to about 5-6 kJ/g	1132:1164	Significant improvement in the flame retardancy of regenerated cellulose was obtained with a reduction of THR values down to about 5-6 kJ/g and an increase of char up to about 35 wt%.
32252261	4	25	theme	initial	725:731	arg1	ratio					745:749	initial cotton / IL ratio	725:749	initial cotton / IL ratio	725:749	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	1	26	theme	1,3-dimethylimidazolium	222:244	arg1	[DIMIM					264:269	1,3-dimethylimidazolium methylphosphonate [DIMIM	222:269	phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2]	183:352	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	1	26	theme	1,3-dimethylimidazolium	222:244	arg1	PO2					349:351	(MeO)(H)PO2	341:351	(MeO)(H)PO2	341:351	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	1	27	theme	1-ethyl-3-methylimidazolium	289:315	arg1	[EMIM					334:338	(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM	272:338	[EMIM	334:338	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	4	28	from	ratio	745:749	arg1	solution					758:765	the solution	754:765	the solution	754:765	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	4	29	theme	IL	742:743	arg1	ratio					745:749	initial cotton / IL ratio	725:749	initial cotton / IL ratio	725:749	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	2	30	theme	transesterification	413:431	arg1	reaction					433:440	a transesterification reaction	411:440	a transesterification reaction between the methyl phosphonate function of ILs and the primary alcohol functions of cellulose	411:534	The chemical modification of cellulose occurred through a transesterification reaction between the methyl phosphonate function of ILs and the primary alcohol functions of cellulose.
32252261	0	31	theme	Cotton	31:36	arg1	Cellulose					38:46	Flame Retardant-Functionalized Cotton Cellulose	0:46	Flame Retardant-Functionalized Cotton Cellulose	0:46	Flame Retardant-Functionalized Cotton Cellulose Using Phosphonate-Based Ionic Liquids.
32252261	1	32	theme	methylphoshonate	317:332	arg1	[EMIM					334:338	(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM	272:338	[EMIM	334:338	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	5	33	theme	cellulose	934:942	arg1	behavior					842:849	The rheological behavior	826:849	The rheological behavior of cotton cellulose/ILs solutions	826:883	The rheological behavior of cotton cellulose/ILs solutions and the microscale fire performances of modified cellulose were studied in order to ultimately prepare flame retardant cellulosic materials.
32252261	5	33	theme	cellulose	934:942	arg1	performances					909:920	the microscale fire performances	889:920	the microscale fire performances of modified cellulose	889:942	The rheological behavior of cotton cellulose/ILs solutions and the microscale fire performances of modified cellulose were studied in order to ultimately prepare flame retardant cellulosic materials.
32252261	6	34	theme	char	1185:1188	arg1	reduction					1119:1127	a reduction	1117:1127	a reduction of THR values down to about 5-6 kJ/g	1117:1164	Significant improvement in the flame retardancy of regenerated cellulose was obtained with a reduction of THR values down to about 5-6 kJ/g and an increase of char up to about 35 wt%.
32252261	6	34	theme	char	1185:1188	arg1	increase					1173:1180	an increase	1170:1180	an increase of char up to about 35 wt%	1170:1207	Significant improvement in the flame retardancy of regenerated cellulose was obtained with a reduction of THR values down to about 5-6 kJ/g and an increase of char up to about 35 wt%.
32252261	4	35	dep	4.5	806:808	arg1	to					803:804	to	803:804	to	803:804	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	0	36	theme	Phosphonate-Based	54:70	arg1	Liquids					78:84	Phosphonate-Based Ionic Liquids	54:84	Phosphonate-Based Ionic Liquids	54:84	Flame Retardant-Functionalized Cotton Cellulose Using Phosphonate-Based Ionic Liquids.
32252261	5	37	theme	cellulosic	1004:1013	arg1	materials					1015:1023	flame retardant cellulosic materials	988:1023	flame retardant cellulosic materials	988:1023	The rheological behavior of cotton cellulose/ILs solutions and the microscale fire performances of modified cellulose were studied in order to ultimately prepare flame retardant cellulosic materials.
32252261	2	38	theme	chemical	359:366	arg1	modification					368:379	The chemical modification	355:379	The chemical modification of cellulose	355:392	The chemical modification of cellulose occurred through a transesterification reaction between the methyl phosphonate function of ILs and the primary alcohol functions of cellulose.
32252261	5	39	theme	rheological	830:840	arg1	behavior					842:849	The rheological behavior	826:849	The rheological behavior of cotton cellulose/ILs solutions	826:883	The rheological behavior of cotton cellulose/ILs solutions and the microscale fire performances of modified cellulose were studied in order to ultimately prepare flame retardant cellulosic materials.
32252261	4	40	contain	contained	790:798	arg1	cellulose					780:788	regenerated cellulose	768:788	regenerated cellulose	768:788	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	4	40	contain	contained	790:798	arg2	%					809:809	up to 4.5%	800:809	up to 4.5% of phosphorus	800:823	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	4	40	contain	contained	790:798	arg2	phosphorus					814:823	phosphorus	814:823	phosphorus	814:823	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	2	41	theme	functions	513:521	arg1	function					473:480	the methyl phosphonate function	450:480	the methyl phosphonate function of ILs and the primary alcohol functions of cellulose	450:534	The chemical modification of cellulose occurred through a transesterification reaction between the methyl phosphonate function of ILs and the primary alcohol functions of cellulose.
32252261	5	42	theme	cellulose/ILs	861:873	arg1	solutions					875:883	cotton cellulose/ILs solutions	854:883	cotton cellulose/ILs solutions	854:883	The rheological behavior of cotton cellulose/ILs solutions and the microscale fire performances of modified cellulose were studied in order to ultimately prepare flame retardant cellulosic materials.
32252261	3	43	theme	grafted	589:595	arg1	phosphorus					597:606	grafted phosphorus	589:606	grafted phosphorus	589:606	The resulting cellulose structure and the amount of grafted phosphorus were then investigated by X-ray diffraction, ICP-AES, and ¹³C and ³¹P NMR spectroscopy.
32252261	4	44	theme	IL	713:714	arg1	type					716:719	IL type	713:719	IL type	713:719	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	0	45	theme	Ionic	72:76	arg1	Liquids					78:84	Phosphonate-Based Ionic Liquids	54:84	Phosphonate-Based Ionic Liquids	54:84	Flame Retardant-Functionalized Cotton Cellulose Using Phosphonate-Based Ionic Liquids.
32252261	3	46	theme	³¹P	674:676	arg1	spectroscopy					682:693	³¹P NMR spectroscopy	674:693	³¹P NMR spectroscopy	674:693	The resulting cellulose structure and the amount of grafted phosphorus were then investigated by X-ray diffraction, ICP-AES, and ¹³C and ³¹P NMR spectroscopy.
32252261	3	47	theme	phosphorus	597:606	arg1	structure					561:569	The resulting cellulose structure	537:569	The resulting cellulose structure	537:569	The resulting cellulose structure and the amount of grafted phosphorus were then investigated by X-ray diffraction, ICP-AES, and ¹³C and ³¹P NMR spectroscopy.
32252261	3	47	theme	phosphorus	597:606	arg1	amount					579:584	the amount	575:584	the amount of grafted phosphorus	575:606	The resulting cellulose structure and the amount of grafted phosphorus were then investigated by X-ray diffraction, ICP-AES, and ¹³C and ³¹P NMR spectroscopy.
32252261	3	47	theme	phosphorus	597:606	arg1	phosphorus					597:606	grafted phosphorus	589:606	grafted phosphorus	589:606	The resulting cellulose structure and the amount of grafted phosphorus were then investigated by X-ray diffraction, ICP-AES, and ¹³C and ³¹P NMR spectroscopy.
32252261	1	48	theme	dissolution-regeneration	145:168	arg1	process					170:176	a dissolution-regeneration process	143:176	a dissolution-regeneration process	143:176	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	1	49	theme	MeO	342:344	arg1	[DIMIM					264:269	1,3-dimethylimidazolium methylphosphonate [DIMIM	222:269	phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2]	183:352	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	1	49	theme	MeO	342:344	arg1	PO2					349:351	(MeO)(H)PO2	341:351	(MeO)(H)PO2	341:351	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	3	50	theme	NMR	678:680	arg1	spectroscopy					682:693	³¹P NMR spectroscopy	674:693	³¹P NMR spectroscopy	674:693	The resulting cellulose structure and the amount of grafted phosphorus were then investigated by X-ray diffraction, ICP-AES, and ¹³C and ³¹P NMR spectroscopy.
32252261	3	51	theme	X-ray	634:638	arg1	diffraction					640:650	X-ray diffraction	634:650	X-ray diffraction	634:650	The resulting cellulose structure and the amount of grafted phosphorus were then investigated by X-ray diffraction, ICP-AES, and ¹³C and ³¹P NMR spectroscopy.
32252261	6	52	theme	Significant	1026:1036	arg1	improvement					1038:1048	Significant improvement	1026:1048	Significant improvement in the flame retardancy of regenerated cellulose	1026:1097	Significant improvement in the flame retardancy of regenerated cellulose was obtained with a reduction of THR values down to about 5-6 kJ/g and an increase of char up to about 35 wt%.
32252261	6	53	theme	THR	1132:1134	arg1	values					1136:1141	THR values	1132:1141	THR values down to about 5-6 kJ/g	1132:1164	Significant improvement in the flame retardancy of regenerated cellulose was obtained with a reduction of THR values down to about 5-6 kJ/g and an increase of char up to about 35 wt%.
32252261	4	54	from	type	716:719	arg1	solution					758:765	the solution	754:765	the solution	754:765	Depending on the IL type and initial cotton / IL ratio in the solution, regenerated cellulose contained up to 4.5% of phosphorus.
32252261	3	55	theme	resulting	541:549	arg1	structure					561:569	The resulting cellulose structure	537:569	The resulting cellulose structure	537:569	The resulting cellulose structure and the amount of grafted phosphorus were then investigated by X-ray diffraction, ICP-AES, and ¹³C and ³¹P NMR spectroscopy.
32252261	5	56	theme	flame	988:992	arg1	materials					1015:1023	flame retardant cellulosic materials	988:1023	flame retardant cellulosic materials	988:1023	The rheological behavior of cotton cellulose/ILs solutions and the microscale fire performances of modified cellulose were studied in order to ultimately prepare flame retardant cellulosic materials.
32252261	1	57	theme	ionic	201:205	arg1	ILs					216:218	ILs	216:218	ILs	216:218	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	1	57	theme	ionic	201:205	arg1	liquids					207:213	phosphonate-based ionic liquids	183:213	phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2]	183:352	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	1	58	from	fibers	109:114	arg1	Cellulose					87:95	Cellulose	87:95	Cellulose from cotton fibers	87:114	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	1	59	theme	MeO	273:275	arg1	PO2					280:282	(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM	272:338	PO2	280:282	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	2	60	theme	alcohol	505:511	arg1	functions					513:521	the primary alcohol functions	493:521	the primary alcohol functions of cellulose	493:534	The chemical modification of cellulose occurred through a transesterification reaction between the methyl phosphonate function of ILs and the primary alcohol functions of cellulose.
32252261	5	61	theme	solutions	875:883	arg1	behavior					842:849	The rheological behavior	826:849	The rheological behavior of cotton cellulose/ILs solutions	826:883	The rheological behavior of cotton cellulose/ILs solutions and the microscale fire performances of modified cellulose were studied in order to ultimately prepare flame retardant cellulosic materials.
32252261	5	61	theme	solutions	875:883	arg1	performances					909:920	the microscale fire performances	889:920	the microscale fire performances of modified cellulose	889:942	The rheological behavior of cotton cellulose/ILs solutions and the microscale fire performances of modified cellulose were studied in order to ultimately prepare flame retardant cellulosic materials.
32252261	5	62	theme	retardant	994:1002	arg1	materials					1015:1023	flame retardant cellulosic materials	988:1023	flame retardant cellulosic materials	988:1023	The rheological behavior of cotton cellulose/ILs solutions and the microscale fire performances of modified cellulose were studied in order to ultimately prepare flame retardant cellulosic materials.
32252261	1	63	theme	methylphosphonate	246:262	arg1	[DIMIM					264:269	1,3-dimethylimidazolium methylphosphonate [DIMIM	222:269	phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2]	183:352	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	1	63	theme	methylphosphonate	246:262	arg1	PO2					349:351	(MeO)(H)PO2	341:351	(MeO)(H)PO2	341:351	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	1	64	theme	phosphonate-based	183:199	arg1	ILs					216:218	ILs	216:218	ILs	216:218	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	1	64	theme	phosphonate-based	183:199	arg1	liquids					207:213	phosphonate-based ionic liquids	183:213	phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2]	183:352	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	5	65	theme	cotton	854:859	arg1	solutions					875:883	cotton cellulose/ILs solutions	854:883	cotton cellulose/ILs solutions	854:883	The rheological behavior of cotton cellulose/ILs solutions and the microscale fire performances of modified cellulose were studied in order to ultimately prepare flame retardant cellulosic materials.
32252261	2	66	theme	primary	497:503	arg1	functions					513:521	the primary alcohol functions	493:521	the primary alcohol functions of cellulose	493:534	The chemical modification of cellulose occurred through a transesterification reaction between the methyl phosphonate function of ILs and the primary alcohol functions of cellulose.
32252261	1	67	dep	[DIMIM	264:269	arg1	[EMIM					334:338	(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM	272:338	[EMIM	334:338	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	1	67	dep	[DIMIM	264:269	arg1	PO2					280:282	(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM	272:338	PO2	280:282	Cellulose from cotton fibers was functionalized through a dissolution-regeneration process with phosphonate-based ionic liquids (ILs): 1,3-dimethylimidazolium methylphosphonate [DIMIM][(MeO)(H)PO2] and 1-ethyl-3-methylimidazolium methylphoshonate [EMIM][(MeO)(H)PO2].
32252261	2	68	theme	methyl	454:459	arg1	function					473:480	the methyl phosphonate function	450:480	the methyl phosphonate function of ILs and the primary alcohol functions of cellulose	450:534	The chemical modification of cellulose occurred through a transesterification reaction between the methyl phosphonate function of ILs and the primary alcohol functions of cellulose.
33285200	5	0	theme	higher	727:732	arg1	HAp					744:746	HAp	744:746	HAp	744:746	Hydrogels with 5% of CNC showed a higher amount of HAp immersed for 14 days, about 28% of HAp.
33285200	5	0	theme	higher	727:732	arg1	amount					734:739	a higher amount	725:739	a higher amount of HAp immersed for 14 days, about 28% of HAp	725:785	Hydrogels with 5% of CNC showed a higher amount of HAp immersed for 14 days, about 28% of HAp.
33285200	2	1	from	influence	390:398	arg1	hydrogel					373:380	pectin hydrogel	366:380	pectin hydrogel	366:380	In this study, we evaluated the direct impact of the different percentages of CNC on pectin hydrogel and the influence of HAp obtained through two methods.
33285200	7	2	theme	hydrogels	936:944	arg1	Biocompatibility					912:927	Biocompatibility	912:927	Biocompatibility of the hydrogels	912:944	Biocompatibility of the hydrogels was evaluated by cell viability using fibroblasts (L929).
33285200	3	3	theme	HCl	460:462	arg1	hydrolysis					464:473	HCl hydrolysis	460:473	HCl hydrolysis	460:473	CNC were obtained from HCl hydrolysis following chemical functionalization through vinyl groups.
33285200	8	4	theme	hybrid	1123:1128	arg1	hydrogels					1130:1138	the hybrid hydrogels	1119:1138	the hybrid hydrogels obtained from chemical precipitation	1119:1175	In general, the hydrogels obtained through the biomimetic method show slightly larger biocompatibility compared to the hybrid hydrogels obtained from chemical precipitation.
33285200	4	5	theme	CNC	552:554	arg1	percentage					538:547	The percentage	534:547	The percentage of CNC	534:554	The percentage of CNC positively induces thermal stability, mechanical properties and HAp mineralization from biomimetic using simulated body fluid (1.5 SBF).
33285200	3	6	theme	vinyl	520:524	arg1	groups					526:531	vinyl groups	520:531	vinyl groups	520:531	CNC were obtained from HCl hydrolysis following chemical functionalization through vinyl groups.
33285200	4	7	theme	thermal	575:581	arg1	stability					583:591	thermal stability	575:591	thermal stability	575:591	The percentage of CNC positively induces thermal stability, mechanical properties and HAp mineralization from biomimetic using simulated body fluid (1.5 SBF).
33285200	0	8	theme	cellulose	101:109	arg1	nanocrystal					111:121	cellulose nanocrystal	101:121	cellulose nanocrystal	101:121	Development of composite hydrogel based on hydroxyapatite mineralization over pectin reinforced with cellulose nanocrystal.
33285200	8	9	theme	chemical	1154:1161	arg1	precipitation					1163:1175	chemical precipitation	1154:1175	chemical precipitation	1154:1175	In general, the hydrogels obtained through the biomimetic method show slightly larger biocompatibility compared to the hybrid hydrogels obtained from chemical precipitation.
33285200	5	10	theme	CNC	714:716	arg1	CNC					714:716	CNC	714:716	CNC	714:716	Hydrogels with 5% of CNC showed a higher amount of HAp immersed for 14 days, about 28% of HAp.
33285200	5	10	theme	CNC	714:716	arg1	%					709:709	5%	708:709	5% of CNC	708:716	Hydrogels with 5% of CNC showed a higher amount of HAp immersed for 14 days, about 28% of HAp.
33285200	2	11	theme	CNC	359:361	arg1	percentages					344:354	the different percentages	330:354	the different percentages of CNC	330:361	In this study, we evaluated the direct impact of the different percentages of CNC on pectin hydrogel and the influence of HAp obtained through two methods.
33285200	2	12	from	impact	320:325	arg1	hydrogel					373:380	pectin hydrogel	366:380	pectin hydrogel	366:380	In this study, we evaluated the direct impact of the different percentages of CNC on pectin hydrogel and the influence of HAp obtained through two methods.
33285200	4	13	theme	body	671:674	arg1	fluid					676:680	simulated body fluid	661:680	simulated body fluid (1.5 SBF)	661:690	The percentage of CNC positively induces thermal stability, mechanical properties and HAp mineralization from biomimetic using simulated body fluid (1.5 SBF).
33285200	4	13	theme	body	671:674	arg1	SBF					687:689	1.5 SBF	683:689	1.5 SBF	683:689	The percentage of CNC positively induces thermal stability, mechanical properties and HAp mineralization from biomimetic using simulated body fluid (1.5 SBF).
33285200	2	14	theme	HAp	403:405	arg1	influence					390:398	the influence	386:398	the influence of HAp obtained through two methods	386:434	In this study, we evaluated the direct impact of the different percentages of CNC on pectin hydrogel and the influence of HAp obtained through two methods.
33285200	2	14	theme	HAp	403:405	arg1	impact					320:325	the direct impact	309:325	the direct impact of the different percentages of CNC on pectin hydrogel	309:380	In this study, we evaluated the direct impact of the different percentages of CNC on pectin hydrogel and the influence of HAp obtained through two methods.
33285200	2	15	theme	percentages	344:354	arg1	influence					390:398	the influence	386:398	the influence of HAp obtained through two methods	386:434	In this study, we evaluated the direct impact of the different percentages of CNC on pectin hydrogel and the influence of HAp obtained through two methods.
33285200	2	15	theme	percentages	344:354	arg1	impact					320:325	the direct impact	309:325	the direct impact of the different percentages of CNC on pectin hydrogel	309:380	In this study, we evaluated the direct impact of the different percentages of CNC on pectin hydrogel and the influence of HAp obtained through two methods.
33285200	0	16	theme	hydrogel	25:32	arg1	Development					0:10	Development	0:10	Development of composite hydrogel based on hydroxyapatite mineralization over pectin	0:83	Development of composite hydrogel based on hydroxyapatite mineralization over pectin reinforced with cellulose nanocrystal.
33285200	1	17	theme	biomimetic	262:271	arg1	method					273:278	the biomimetic method	258:278	the biomimetic method	258:278	Hydrogels based on pectin and cellulose nanocrystals (CNC) were used in our study to nucleation and growth of hydroxyapatite (HAp) by the biomimetic method.
33285200	4	18	theme	HAp	620:622	arg1	mineralization					624:637	HAp mineralization	620:637	HAp mineralization	620:637	The percentage of CNC positively induces thermal stability, mechanical properties and HAp mineralization from biomimetic using simulated body fluid (1.5 SBF).
33285200	0	19	theme	composite	15:23	arg1	hydrogel					25:32	composite hydrogel	15:32	composite hydrogel based on hydroxyapatite mineralization over pectin	15:83	Development of composite hydrogel based on hydroxyapatite mineralization over pectin reinforced with cellulose nanocrystal.
33285200	1	20	theme	cellulose	154:162	arg1	nanocrystals					164:175	cellulose nanocrystals	154:175	cellulose nanocrystals (CNC)	154:181	Hydrogels based on pectin and cellulose nanocrystals (CNC) were used in our study to nucleation and growth of hydroxyapatite (HAp) by the biomimetic method.
33285200	1	20	theme	cellulose	154:162	arg1	CNC					178:180	CNC	178:180	CNC	178:180	Hydrogels based on pectin and cellulose nanocrystals (CNC) were used in our study to nucleation and growth of hydroxyapatite (HAp) by the biomimetic method.
33285200	4	21	theme	simulated	661:669	arg1	fluid					676:680	simulated body fluid	661:680	simulated body fluid (1.5 SBF)	661:690	The percentage of CNC positively induces thermal stability, mechanical properties and HAp mineralization from biomimetic using simulated body fluid (1.5 SBF).
33285200	4	21	theme	simulated	661:669	arg1	SBF					687:689	1.5 SBF	683:689	1.5 SBF	683:689	The percentage of CNC positively induces thermal stability, mechanical properties and HAp mineralization from biomimetic using simulated body fluid (1.5 SBF).
33285200	5	22	theme	HAp	783:785	arg1	HAp					783:785	HAp	783:785	HAp	783:785	Hydrogels with 5% of CNC showed a higher amount of HAp immersed for 14 days, about 28% of HAp.
33285200	5	22	theme	HAp	783:785	arg1	%					778:778	about 28%	770:778	about 28% of HAp	770:785	Hydrogels with 5% of CNC showed a higher amount of HAp immersed for 14 days, about 28% of HAp.
33285200	5	22	theme	HAp	783:785	arg1	14 days					761:767	14 days	761:767	14 days	761:767	Hydrogels with 5% of CNC showed a higher amount of HAp immersed for 14 days, about 28% of HAp.
33285200	5	23	theme	HAp	744:746	arg1	HAp					744:746	HAp	744:746	HAp	744:746	Hydrogels with 5% of CNC showed a higher amount of HAp immersed for 14 days, about 28% of HAp.
33285200	5	23	theme	HAp	744:746	arg1	amount					734:739	a higher amount	725:739	a higher amount of HAp immersed for 14 days, about 28% of HAp	725:785	Hydrogels with 5% of CNC showed a higher amount of HAp immersed for 14 days, about 28% of HAp.
33285200	6	24	theme	chemical	888:895	arg1	precipitation					897:909	chemical precipitation	888:909	chemical precipitation	888:909	The obtained hydrogels were compared with hydrogels containing 20% of HAp nanoparticles obtained by chemical precipitation.
33285200	6	25	theme	obtained	792:799	arg1	hydrogels					801:809	The obtained hydrogels	788:809	The obtained hydrogels	788:809	The obtained hydrogels were compared with hydrogels containing 20% of HAp nanoparticles obtained by chemical precipitation.
33285200	2	26	theme	pectin	366:371	arg1	hydrogel					373:380	pectin hydrogel	366:380	pectin hydrogel	366:380	In this study, we evaluated the direct impact of the different percentages of CNC on pectin hydrogel and the influence of HAp obtained through two methods.
33285200	8	27	theme	biomimetic	1051:1060	arg1	method					1062:1067	the biomimetic method	1047:1067	the biomimetic method	1047:1067	In general, the hydrogels obtained through the biomimetic method show slightly larger biocompatibility compared to the hybrid hydrogels obtained from chemical precipitation.
33285200	2	28	theme	direct	313:318	arg1	impact					320:325	the direct impact	309:325	the direct impact of the different percentages of CNC on pectin hydrogel	309:380	In this study, we evaluated the direct impact of the different percentages of CNC on pectin hydrogel and the influence of HAp obtained through two methods.
33285200	0	29	theme	hydroxyapatite	43:56	arg1	mineralization					58:71	hydroxyapatite mineralization	43:71	hydroxyapatite mineralization	43:71	Development of composite hydrogel based on hydroxyapatite mineralization over pectin reinforced with cellulose nanocrystal.
33285200	6	30	theme	nanoparticles	862:874	arg1	%					853:853	20%	851:853	20% of HAp nanoparticles obtained by chemical precipitation	851:909	The obtained hydrogels were compared with hydrogels containing 20% of HAp nanoparticles obtained by chemical precipitation.
33285200	6	30	theme	nanoparticles	862:874	arg1	nanoparticles					862:874	HAp nanoparticles	858:874	HAp nanoparticles obtained by chemical precipitation	858:909	The obtained hydrogels were compared with hydrogels containing 20% of HAp nanoparticles obtained by chemical precipitation.
33285200	7	31	theme	cell	963:966	arg1	viability					968:976	cell viability	963:976	cell viability	963:976	Biocompatibility of the hydrogels was evaluated by cell viability using fibroblasts (L929).
33285200	1	32	used	used	188:191	arg2	Hydrogels					124:132	Hydrogels	124:132	Hydrogels based on pectin and cellulose nanocrystals (CNC)	124:181	Hydrogels based on pectin and cellulose nanocrystals (CNC) were used in our study to nucleation and growth of hydroxyapatite (HAp) by the biomimetic method.
33285200	8	33	theme	larger	1083:1088	arg1	biocompatibility					1090:1105	slightly larger biocompatibility	1074:1105	slightly larger biocompatibility	1074:1105	In general, the hydrogels obtained through the biomimetic method show slightly larger biocompatibility compared to the hybrid hydrogels obtained from chemical precipitation.
33285200	6	34	contain	containing	840:849	arg1	hydrogels					830:838	hydrogels	830:838	hydrogels containing 20% of HAp nanoparticles obtained by chemical precipitation	830:909	The obtained hydrogels were compared with hydrogels containing 20% of HAp nanoparticles obtained by chemical precipitation.
33285200	6	34	contain	containing	840:849	arg2	nanoparticles					862:874	HAp nanoparticles	858:874	HAp nanoparticles obtained by chemical precipitation	858:909	The obtained hydrogels were compared with hydrogels containing 20% of HAp nanoparticles obtained by chemical precipitation.
33285200	6	34	contain	containing	840:849	arg2	%					853:853	20%	851:853	20% of HAp nanoparticles obtained by chemical precipitation	851:909	The obtained hydrogels were compared with hydrogels containing 20% of HAp nanoparticles obtained by chemical precipitation.
33285200	5	35	with	Hydrogels	693:701	arg1	CNC					714:716	CNC	714:716	CNC	714:716	Hydrogels with 5% of CNC showed a higher amount of HAp immersed for 14 days, about 28% of HAp.
33285200	5	35	with	Hydrogels	693:701	arg1	%					709:709	5%	708:709	5% of CNC	708:716	Hydrogels with 5% of CNC showed a higher amount of HAp immersed for 14 days, about 28% of HAp.
33285200	2	36	theme	different	334:342	arg1	percentages					344:354	the different percentages	330:354	the different percentages of CNC	330:361	In this study, we evaluated the direct impact of the different percentages of CNC on pectin hydrogel and the influence of HAp obtained through two methods.
33285200	6	37	theme	HAp	858:860	arg1	nanoparticles					862:874	HAp nanoparticles	858:874	HAp nanoparticles obtained by chemical precipitation	858:909	The obtained hydrogels were compared with hydrogels containing 20% of HAp nanoparticles obtained by chemical precipitation.
33285200	4	38	theme	mechanical	594:603	arg1	properties					605:614	mechanical properties	594:614	mechanical properties	594:614	The percentage of CNC positively induces thermal stability, mechanical properties and HAp mineralization from biomimetic using simulated body fluid (1.5 SBF).
33285200	3	39	theme	chemical	485:492	arg1	functionalization					494:510	chemical functionalization	485:510	chemical functionalization through vinyl groups	485:531	CNC were obtained from HCl hydrolysis following chemical functionalization through vinyl groups.
33285200	1	40	theme	hydroxyapatite	234:247	arg1	growth					224:229	growth	224:229	growth	224:229	Hydrogels based on pectin and cellulose nanocrystals (CNC) were used in our study to nucleation and growth of hydroxyapatite (HAp) by the biomimetic method.
33285200	1	40	theme	hydroxyapatite	234:247	arg1	nucleation					209:218	nucleation	209:218	nucleation	209:218	Hydrogels based on pectin and cellulose nanocrystals (CNC) were used in our study to nucleation and growth of hydroxyapatite (HAp) by the biomimetic method.
33594820	0	0	theme	Polyoxomolibdate	93:108	arg1	oxide					131:135	Polyoxomolibdate nanocluster/Graphene oxide	93:135	Polyoxomolibdate nanocluster/Graphene oxide	93:135	Solid-phase microextraction of methadone by using a chitosan nanocomposite incorporated with Polyoxomolibdate nanocluster/Graphene oxide.
33594820	1	1	theme	mobility	365:372	arg1	spectrometry					374:385	the ion mobility spectrometry	357:385	the ion mobility spectrometry for the analysis of methadone in biological matrices	357:438	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	5	2	theme	different	859:867	arg1	variables					886:894	different input and output variables	859:894	different input and output variables	859:894	Afterward, to study the relationship between different input and output variables as well as to identify the optimal operating conditions, response surface methodology was used, whereby a second-order polynomial equation was fit to the experimental data.
33594820	7	3	theme	calibration	1295:1305	arg1	linear					1316:1321	linear	1316:1321	linear	1316:1321	The detection limit of 0.12 ng/mL was obtained at the optimized extraction conditions, and the calibration plot was linear in the concentration range of 0.30-200 ng/mL.
33594820	7	3	theme	calibration	1295:1305	arg1	plot					1307:1310	the calibration plot	1291:1310	the calibration plot	1291:1310	The detection limit of 0.12 ng/mL was obtained at the optimized extraction conditions, and the calibration plot was linear in the concentration range of 0.30-200 ng/mL.
33594820	5	4	theme	input	869:873	arg1	variables					886:894	different input and output variables	859:894	different input and output variables	859:894	Afterward, to study the relationship between different input and output variables as well as to identify the optimal operating conditions, response surface methodology was used, whereby a second-order polynomial equation was fit to the experimental data.
33594820	6	5	theme	%	1194:1194	arg1	time					1152:1155	extraction time	1141:1155	extraction time	1141:1155	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	6	5	theme	%	1194:1194	arg1	w/v					1195:1197	5%w/v	1193:1197	5%w/v	1193:1197	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	1	6	from	matrices	431:438	arg1	analysis					395:402	the analysis	391:402	the analysis of methadone in biological matrices	391:438	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	5	7	theme	experimental	1050:1061	arg1	data					1063:1066	the experimental data	1046:1066	the experimental data	1046:1066	Afterward, to study the relationship between different input and output variables as well as to identify the optimal operating conditions, response surface methodology was used, whereby a second-order polynomial equation was fit to the experimental data.
33594820	8	8	theme	proposed	1433:1440	arg1	method					1442:1447	the proposed method	1429:1447	the proposed method	1429:1447	With relatively low limit of detection and good precisions, the proposed method has the potential for the extraction and determination of methadone in biological samples.
33594820	6	9	theme	extraction	1083:1092	arg1	conditions					1094:1103	The optimized extraction conditions	1069:1103	The optimized extraction conditions	1069:1103	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	0	10	theme	nanocluster/Graphene	110:129	arg1	oxide					131:135	Polyoxomolibdate nanocluster/Graphene oxide	93:135	Polyoxomolibdate nanocluster/Graphene oxide	93:135	Solid-phase microextraction of methadone by using a chitosan nanocomposite incorporated with Polyoxomolibdate nanocluster/Graphene oxide.
33594820	8	11	theme	detection	1398:1406	arg1	limit					1389:1393	relatively low limit	1374:1393	relatively low limit of detection and good precisions	1374:1426	With relatively low limit of detection and good precisions, the proposed method has the potential for the extraction and determination of methadone in biological samples.
33594820	5	12	theme	operating	931:939	arg1	conditions					941:950	the optimal operating conditions	919:950	the optimal operating conditions	919:950	Afterward, to study the relationship between different input and output variables as well as to identify the optimal operating conditions, response surface methodology was used, whereby a second-order polynomial equation was fit to the experimental data.
33594820	7	13	theme	concentration	1330:1342	arg1	range					1344:1348	the concentration range	1326:1348	the concentration range of 0.30-200 ng/mL	1326:1366	The detection limit of 0.12 ng/mL was obtained at the optimized extraction conditions, and the calibration plot was linear in the concentration range of 0.30-200 ng/mL.
33594820	5	14	theme	optimal	923:929	arg1	conditions					941:950	the optimal operating conditions	919:950	the optimal operating conditions	919:950	Afterward, to study the relationship between different input and output variables as well as to identify the optimal operating conditions, response surface methodology was used, whereby a second-order polynomial equation was fit to the experimental data.
33594820	4	15	theme	composite	711:719	arg1	design					733:738	A central composite statistical design	701:738	A central composite statistical design	701:738	A central composite statistical design was used to study the main variables affecting the extraction efficiency.
33594820	8	16	theme	precisions	1417:1426	arg1	limit					1389:1393	relatively low limit	1374:1393	relatively low limit of detection and good precisions	1374:1426	With relatively low limit of detection and good precisions, the proposed method has the potential for the extraction and determination of methadone in biological samples.
33594820	1	17	theme	simple	177:182	arg1	preparation					192:202	the simple sol-gel preparation	173:202	the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide	173:275	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	6	18	theme	optimized	1073:1081	arg1	conditions					1094:1103	The optimized extraction conditions	1069:1103	The optimized extraction conditions	1069:1103	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	6	19	dep	temperature	1122:1132	arg1	15 min					1158:1163	15 min	1158:1163	15 min	1158:1163	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	6	19	dep	temperature	1122:1132	arg1	concentration					1170:1182	concentration	1170:1182	concentration	1170:1182	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	6	19	dep	temperature	1122:1132	arg1	time					1152:1155	extraction time	1141:1155	extraction time	1141:1155	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	6	19	dep	temperature	1122:1132	arg1	w/v					1195:1197	5%w/v	1193:1197	5%w/v	1193:1197	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	8	20	theme	good	1412:1415	arg1	precisions					1417:1426	good precisions	1412:1426	good precisions	1412:1426	With relatively low limit of detection and good precisions, the proposed method has the potential for the extraction and determination of methadone in biological samples.
33594820	8	21	dep	extraction	1475:1484	arg1	the					1471:1473	the	1471:1473	the	1471:1473	With relatively low limit of detection and good precisions, the proposed method has the potential for the extraction and determination of methadone in biological samples.
33594820	1	22	from	methadone	407:415	arg1	matrices					431:438	biological matrices	420:438	biological matrices	420:438	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	1	23	theme	sol-gel	184:190	arg1	preparation					192:202	the simple sol-gel preparation	173:202	the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide	173:275	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	2	24	theme	infrared	499:506	arg1	spectroscopy					508:519	the infrared spectroscopy	495:519	the infrared spectroscopy	495:519	The developed nanocomposite was characterized through the infrared spectroscopy and thermogravimetric analyses.
33594820	1	25	theme	methadone	407:415	arg1	analysis					395:402	the analysis	391:402	the analysis of methadone in biological matrices	391:438	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	5	26	theme	surface	962:968	arg1	methodology					970:980	response surface methodology	953:980	response surface methodology	953:980	Afterward, to study the relationship between different input and output variables as well as to identify the optimal operating conditions, response surface methodology was used, whereby a second-order polynomial equation was fit to the experimental data.
33594820	0	27	theme	Solid-phase	0:10	arg1	microextraction					12:26	Solid-phase microextraction	0:26	Solid-phase microextraction of methadone by using a chitosan nanocomposite	0:73	Solid-phase microextraction of methadone by using a chitosan nanocomposite incorporated with Polyoxomolibdate nanocluster/Graphene oxide.
33594820	8	28	theme	low	1385:1387	arg1	limit					1389:1393	relatively low limit	1374:1393	relatively low limit of detection and good precisions	1374:1426	With relatively low limit of detection and good precisions, the proposed method has the potential for the extraction and determination of methadone in biological samples.
33594820	8	29	from	determination	1490:1502	arg1	samples					1531:1537	biological samples	1520:1537	biological samples	1520:1537	With relatively low limit of detection and good precisions, the proposed method has the potential for the extraction and determination of methadone in biological samples.
33594820	0	30	theme	methadone	31:39	arg1	microextraction					12:26	Solid-phase microextraction	0:26	Solid-phase microextraction of methadone by using a chitosan nanocomposite	0:73	Solid-phase microextraction of methadone by using a chitosan nanocomposite incorporated with Polyoxomolibdate nanocluster/Graphene oxide.
33594820	7	31	from	linear	1316:1321	arg1	range					1344:1348	the concentration range	1326:1348	the concentration range of 0.30-200 ng/mL	1326:1366	The detection limit of 0.12 ng/mL was obtained at the optimized extraction conditions, and the calibration plot was linear in the concentration range of 0.30-200 ng/mL.
33594820	3	32	theme	high	636:639	arg1	efficiency					652:661	high extraction efficiency	636:661	high extraction efficiency	636:661	The ternary nanocomposite coating offers good mechanical and thermal stability and high extraction efficiency thanks to its large specific surface.
33594820	4	33	theme	statistical	721:731	arg1	design					733:738	A central composite statistical design	701:738	A central composite statistical design	701:738	A central composite statistical design was used to study the main variables affecting the extraction efficiency.
33594820	1	34	from	analysis	395:402	arg1	matrices					431:438	biological matrices	420:438	biological matrices	420:438	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	1	35	theme	headspace	305:313	arg1	microextraction					327:341	the headspace solid-phase microextraction	301:341	the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices	301:438	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	1	36	from	application	286:296	arg1	microextraction					327:341	the headspace solid-phase microextraction	301:341	the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices	301:438	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	8	37	theme	methadone	1507:1515	arg1	extraction					1475:1484	extraction	1475:1484	extraction	1475:1484	With relatively low limit of detection and good precisions, the proposed method has the potential for the extraction and determination of methadone in biological samples.
33594820	8	37	theme	methadone	1507:1515	arg1	determination					1490:1502	determination	1490:1502	determination	1490:1502	With relatively low limit of detection and good precisions, the proposed method has the potential for the extraction and determination of methadone in biological samples.
33594820	3	38	theme	extraction	641:650	arg1	efficiency					652:661	high extraction efficiency	636:661	high extraction efficiency	636:661	The ternary nanocomposite coating offers good mechanical and thermal stability and high extraction efficiency thanks to its large specific surface.
33594820	8	39	from	extraction	1475:1484	arg1	samples					1531:1537	biological samples	1520:1537	biological samples	1520:1537	With relatively low limit of detection and good precisions, the proposed method has the potential for the extraction and determination of methadone in biological samples.
33594820	1	40	theme	nanocomposite	209:221	arg1	preparation					192:202	the simple sol-gel preparation	173:202	the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide	173:275	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	1	40	theme	nanocomposite	209:221	arg1	application					286:296	its application	282:296	its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices	282:438	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	7	41	theme	detection	1204:1212	arg1	limit					1214:1218	The detection limit	1200:1218	The detection limit of 0.12 ng/mL	1200:1232	The detection limit of 0.12 ng/mL was obtained at the optimized extraction conditions, and the calibration plot was linear in the concentration range of 0.30-200 ng/mL.
33594820	1	42	theme	solid-phase	315:325	arg1	microextraction					327:341	the headspace solid-phase microextraction	301:341	the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices	301:438	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	1	43	theme	biological	420:429	arg1	matrices					431:438	biological matrices	420:438	biological matrices	420:438	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	3	44	theme	large	677:681	arg1	surface					692:698	its large specific surface	673:698	its large specific surface	673:698	The ternary nanocomposite coating offers good mechanical and thermal stability and high extraction efficiency thanks to its large specific surface.
33594820	2	45	theme	developed	445:453	arg1	nanocomposite					455:467	The developed nanocomposite	441:467	The developed nanocomposite	441:467	The developed nanocomposite was characterized through the infrared spectroscopy and thermogravimetric analyses.
33594820	2	46	theme	thermogravimetric	525:541	arg1	analyses					543:550	thermogravimetric analyses	525:550	thermogravimetric analyses	525:550	The developed nanocomposite was characterized through the infrared spectroscopy and thermogravimetric analyses.
33594820	5	47	theme	output	879:884	arg1	variables					886:894	different input and output variables	859:894	different input and output variables	859:894	Afterward, to study the relationship between different input and output variables as well as to identify the optimal operating conditions, response surface methodology was used, whereby a second-order polynomial equation was fit to the experimental data.
33594820	8	48	theme	biological	1520:1529	arg1	samples					1531:1537	biological samples	1520:1537	biological samples	1520:1537	With relatively low limit of detection and good precisions, the proposed method has the potential for the extraction and determination of methadone in biological samples.
33594820	3	49	theme	specific	683:690	arg1	surface					692:698	its large specific surface	673:698	its large specific surface	673:698	The ternary nanocomposite coating offers good mechanical and thermal stability and high extraction efficiency thanks to its large specific surface.
33594820	7	50	theme	0.30-200 ng/mL	1353:1366	arg1	range					1344:1348	the concentration range	1326:1348	the concentration range of 0.30-200 ng/mL	1326:1366	The detection limit of 0.12 ng/mL was obtained at the optimized extraction conditions, and the calibration plot was linear in the concentration range of 0.30-200 ng/mL.
33594820	0	51	theme	chitosan	52:59	arg1	nanocomposite					61:73	a chitosan nanocomposite	50:73	a chitosan nanocomposite	50:73	Solid-phase microextraction of methadone by using a chitosan nanocomposite incorporated with Polyoxomolibdate nanocluster/Graphene oxide.
33594820	7	52	theme	optimized	1254:1262	arg1	conditions					1275:1284	the optimized extraction conditions	1250:1284	the optimized extraction conditions	1250:1284	The detection limit of 0.12 ng/mL was obtained at the optimized extraction conditions, and the calibration plot was linear in the concentration range of 0.30-200 ng/mL.
33594820	7	53	theme	extraction	1264:1273	arg1	conditions					1275:1284	the optimized extraction conditions	1250:1284	the optimized extraction conditions	1250:1284	The detection limit of 0.12 ng/mL was obtained at the optimized extraction conditions, and the calibration plot was linear in the concentration range of 0.30-200 ng/mL.
33594820	5	54	used	used	986:989	arg2	methodology					970:980	response surface methodology	953:980	response surface methodology	953:980	Afterward, to study the relationship between different input and output variables as well as to identify the optimal operating conditions, response surface methodology was used, whereby a second-order polynomial equation was fit to the experimental data.
33594820	6	55	theme	NaCl	1187:1190	arg1	15 min					1158:1163	15 min	1158:1163	15 min	1158:1163	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	6	55	theme	NaCl	1187:1190	arg1	concentration					1170:1182	concentration	1170:1182	concentration	1170:1182	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	6	55	theme	NaCl	1187:1190	arg1	time					1152:1155	extraction time	1141:1155	extraction time	1141:1155	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	6	55	theme	NaCl	1187:1190	arg1	w/v					1195:1197	5%w/v	1193:1197	5%w/v	1193:1197	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	3	56	theme	ternary	557:563	arg1	coating					579:585	The ternary nanocomposite coating	553:585	The ternary nanocomposite coating	553:585	The ternary nanocomposite coating offers good mechanical and thermal stability and high extraction efficiency thanks to its large specific surface.
33594820	4	57	used	used	744:747	arg2	design					733:738	A central composite statistical design	701:738	A central composite statistical design	701:738	A central composite statistical design was used to study the main variables affecting the extraction efficiency.
33594820	1	58	theme	present	145:151	arg1	study					153:157	the present study	141:157	the present study	141:157	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	5	59	theme	second-order	1002:1013	arg1	equation					1026:1033	a second-order polynomial equation	1000:1033	a second-order polynomial equation	1000:1033	Afterward, to study the relationship between different input and output variables as well as to identify the optimal operating conditions, response surface methodology was used, whereby a second-order polynomial equation was fit to the experimental data.
33594820	5	60	theme	polynomial	1015:1024	arg1	equation					1026:1033	a second-order polynomial equation	1000:1033	a second-order polynomial equation	1000:1033	Afterward, to study the relationship between different input and output variables as well as to identify the optimal operating conditions, response surface methodology was used, whereby a second-order polynomial equation was fit to the experimental data.
33594820	1	61	theme	chitosan/	235:243	arg1	oxide					271:275	chitosan/ polyoxometalate /graphene oxide	235:275	chitosan/ polyoxometalate /graphene oxide	235:275	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	3	62	theme	thermal	614:620	arg1	stability					622:630	good mechanical and thermal stability	594:630	good mechanical and thermal stability	594:630	The ternary nanocomposite coating offers good mechanical and thermal stability and high extraction efficiency thanks to its large specific surface.
33594820	6	63	theme	extraction	1141:1150	arg1	time					1152:1155	extraction time	1141:1155	extraction time	1141:1155	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	6	63	theme	extraction	1141:1150	arg1	w/v					1195:1197	5%w/v	1193:1197	5%w/v	1193:1197	The optimized extraction conditions were as follows: temperature, 70°C; extraction time, 15 min; and concentration of NaCl, 5%w/v.
33594820	1	64	from	preparation	192:202	arg1	microextraction					327:341	the headspace solid-phase microextraction	301:341	the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices	301:438	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	4	65	theme	main	762:765	arg1	variables					767:775	the main variables	758:775	the main variables affecting the extraction efficiency	758:811	A central composite statistical design was used to study the main variables affecting the extraction efficiency.
33594820	1	66	theme	polyoxometalate	245:259	arg1	oxide					271:275	chitosan/ polyoxometalate /graphene oxide	235:275	chitosan/ polyoxometalate /graphene oxide	235:275	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	4	67	theme	central	703:709	arg1	design					733:738	A central composite statistical design	701:738	A central composite statistical design	701:738	A central composite statistical design was used to study the main variables affecting the extraction efficiency.
33594820	3	68	theme	good	594:597	arg1	stability					622:630	good mechanical and thermal stability	594:630	good mechanical and thermal stability	594:630	The ternary nanocomposite coating offers good mechanical and thermal stability and high extraction efficiency thanks to its large specific surface.
33594820	5	69	theme	response	953:960	arg1	methodology					970:980	response surface methodology	953:980	response surface methodology	953:980	Afterward, to study the relationship between different input and output variables as well as to identify the optimal operating conditions, response surface methodology was used, whereby a second-order polynomial equation was fit to the experimental data.
33594820	1	70	theme	/graphene	261:269	arg1	oxide					271:275	chitosan/ polyoxometalate /graphene oxide	235:275	chitosan/ polyoxometalate /graphene oxide	235:275	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	8	71	contain	has	1449:1451	arg2	potential					1457:1465	the potential	1453:1465	the potential for the extraction and determination of methadone in biological samples	1453:1537	With relatively low limit of detection and good precisions, the proposed method has the potential for the extraction and determination of methadone in biological samples.
33594820	8	71	contain	has	1449:1451	arg1	method					1442:1447	the proposed method	1429:1447	the proposed method	1429:1447	With relatively low limit of detection and good precisions, the proposed method has the potential for the extraction and determination of methadone in biological samples.
33594820	1	72	theme	ion	361:363	arg1	spectrometry					374:385	the ion mobility spectrometry	357:385	the ion mobility spectrometry for the analysis of methadone in biological matrices	357:438	In the present study, we report on the simple sol-gel preparation of a nanocomposite composed of chitosan/ polyoxometalate /graphene oxide, and its application in the headspace solid-phase microextraction combined with the ion mobility spectrometry for the analysis of methadone in biological matrices.
33594820	7	73	theme	0.12 ng/mL	1223:1232	arg1	limit					1214:1218	The detection limit	1200:1218	The detection limit of 0.12 ng/mL	1200:1232	The detection limit of 0.12 ng/mL was obtained at the optimized extraction conditions, and the calibration plot was linear in the concentration range of 0.30-200 ng/mL.
33594820	3	74	theme	mechanical	599:608	arg1	stability					622:630	good mechanical and thermal stability	594:630	good mechanical and thermal stability	594:630	The ternary nanocomposite coating offers good mechanical and thermal stability and high extraction efficiency thanks to its large specific surface.
33594820	3	75	theme	nanocomposite	565:577	arg1	coating					579:585	The ternary nanocomposite coating	553:585	The ternary nanocomposite coating	553:585	The ternary nanocomposite coating offers good mechanical and thermal stability and high extraction efficiency thanks to its large specific surface.
33594820	4	76	theme	extraction	791:800	arg1	efficiency					802:811	the extraction efficiency	787:811	the extraction efficiency	787:811	A central composite statistical design was used to study the main variables affecting the extraction efficiency.
32817943	9	0	theme	proteins	1333:1340	arg1	studies					1316:1322	future studies	1309:1322	future studies of spike proteins with receptors, antibodies, or drugs	1309:1377	This structure provides the basis for future studies of spike proteins with receptors, antibodies, or drugs, in the native state of the coronavirus particles.
32817943	7	1	theme	observed	964:971	arg1	sites					987:991	observed glycosylation sites	964:991	observed glycosylation sites	964:991	In addition to previously proposed and observed glycosylation sites, our map shows density at other amino acid positions as well as differences in glycan structures.
32817943	2	2	theme	upper	337:341	arg1	symptoms					355:362	mild upper respiratory symptoms	332:362	mild upper respiratory symptoms in children, elderly and immunocompromised individuals	332:417	HCoV-NL63 is typically associated with mild upper respiratory symptoms in children, elderly and immunocompromised individuals.
32817943	5	3	theme	chemical	715:722	arg1	fixative					724:731	chemical fixative	715:731	chemical fixative	715:731	Here we present the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative.
32817943	5	4	theme	S	621:621	arg1	trimer					624:629	HCoV-NL63 spike (S) trimer	604:629	HCoV-NL63 spike (S) trimer	604:629	Here we present the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative.
32817943	2	5	theme	mild	332:335	arg1	symptoms					355:362	mild upper respiratory symptoms	332:362	mild upper respiratory symptoms in children, elderly and immunocompromised individuals	332:417	HCoV-NL63 is typically associated with mild upper respiratory symptoms in children, elderly and immunocompromised individuals.
32817943	7	6	from	positions	1036:1044	arg1	density					1008:1014	density	1008:1014	density at other amino acid positions as well as differences in glycan structures	1008:1088	In addition to previously proposed and observed glycosylation sites, our map shows density at other amino acid positions as well as differences in glycan structures.
32817943	7	6	from	positions	1036:1044	arg1	structures					1079:1088	glycan structures	1072:1088	glycan structures	1072:1088	In addition to previously proposed and observed glycosylation sites, our map shows density at other amino acid positions as well as differences in glycan structures.
32817943	0	7	theme	vitrified	93:101	arg1	particles					114:122	vitrified NL63 virus particles	93:122	vitrified NL63 virus particles	93:122	A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles.
32817943	6	8	theme	symmetric	882:890	arg1	trimer					892:897	a 3-fold symmetric trimer	873:897	a 3-fold symmetric trimer in a single conformation	873:922	It is structurally homologous to that obtained previously from the biochemically purified ectodomain of HCoV-NL63 S trimer, which displays a 3-fold symmetric trimer in a single conformation.
32817943	9	9	with	proteins	1333:1340	arg1	antibodies					1358:1367	antibodies	1358:1367	antibodies	1358:1367	This structure provides the basis for future studies of spike proteins with receptors, antibodies, or drugs, in the native state of the coronavirus particles.
32817943	9	9	with	proteins	1333:1340	arg1	drugs					1373:1377	drugs	1373:1377	drugs	1373:1377	This structure provides the basis for future studies of spike proteins with receptors, antibodies, or drugs, in the native state of the coronavirus particles.
32817943	9	9	with	proteins	1333:1340	arg1	receptors					1347:1355	receptors	1347:1355	receptors	1347:1355	This structure provides the basis for future studies of spike proteins with receptors, antibodies, or drugs, in the native state of the coronavirus particles.
32817943	5	10	theme	virions	699:705	arg1	imaging					678:684	single-particle cryo-EM imaging	654:684	single-particle cryo-EM imaging of vitrified virions without chemical fixative	654:731	Here we present the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative.
32817943	5	11	theme	trimer	624:629	arg1	structure					591:599	the in situ structure	579:599	the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative	579:731	Here we present the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative.
32817943	5	12	theme	in	583:584	arg1	structure					591:599	the in situ structure	579:599	the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative	579:731	Here we present the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative.
32817943	9	13	theme	native	1387:1392	arg1	state					1394:1398	the native state	1383:1398	the native state of the coronavirus particles	1383:1427	This structure provides the basis for future studies of spike proteins with receptors, antibodies, or drugs, in the native state of the coronavirus particles.
32817943	0	14	theme	virus	108:112	arg1	particles					114:122	vitrified NL63 virus particles	93:122	vitrified NL63 virus particles	93:122	A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles.
32817943	8	15	theme	different	1208:1216	arg1	requirements					1218:1229	their different requirements	1202:1229	their different requirements for activating binding to the receptor	1202:1268	The domain arrangement within a protomer is strikingly different from that of the SARS-CoV-2 S and may explain their different requirements for activating binding to the receptor.
32817943	0	16	theme	NL63	103:106	arg1	particles					114:122	vitrified NL63 virus particles	93:122	vitrified NL63 virus particles	93:122	A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles.
32817943	7	17	theme	glycan	1072:1077	arg1	structures					1079:1088	glycan structures	1072:1088	glycan structures	1072:1088	In addition to previously proposed and observed glycosylation sites, our map shows density at other amino acid positions as well as differences in glycan structures.
32817943	0	18	theme	3.4-Å	2:6	arg1	structure					16:24	A 3.4-Å cryo-EM structure	0:24	A 3.4-Å cryo-EM structure of the human coronavirus spike trimer	0:62	A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles.
32817943	9	19	theme	spike	1327:1331	arg1	proteins					1333:1340	spike proteins	1327:1340	spike proteins with receptors, antibodies, or drugs	1327:1377	This structure provides the basis for future studies of spike proteins with receptors, antibodies, or drugs, in the native state of the coronavirus particles.
32817943	6	20	from	trimer	892:897	arg1	conformation					911:922	a single conformation	902:922	a single conformation	902:922	It is structurally homologous to that obtained previously from the biochemically purified ectodomain of HCoV-NL63 S trimer, which displays a 3-fold symmetric trimer in a single conformation.
32817943	7	21	theme	amino	1025:1029	arg1	positions					1036:1044	other amino acid positions	1019:1044	other amino acid positions as well as differences in glycan structures	1019:1088	In addition to previously proposed and observed glycosylation sites, our map shows density at other amino acid positions as well as differences in glycan structures.
32817943	1	22	theme	enveloped	166:174	arg1	pathogen					176:183	an enveloped pathogen	163:183	an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases	163:290	Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases.
32817943	1	22	theme	enveloped	166:174	arg1	coronavirus					131:141	Human coronavirus NL63	125:146	Human coronavirus NL63 (HCoV-NL63)	125:158	Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases.
32817943	9	23	theme	future	1309:1314	arg1	studies					1316:1322	future studies	1309:1322	future studies of spike proteins with receptors, antibodies, or drugs	1309:1377	This structure provides the basis for future studies of spike proteins with receptors, antibodies, or drugs, in the native state of the coronavirus particles.
32817943	5	24	theme	spike	614:618	arg1	trimer					624:629	HCoV-NL63 spike (S) trimer	604:629	HCoV-NL63 spike (S) trimer	604:629	Here we present the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative.
32817943	2	25	from	symptoms	355:362	arg1	elderly					377:383	elderly	377:383	elderly	377:383	HCoV-NL63 is typically associated with mild upper respiratory symptoms in children, elderly and immunocompromised individuals.
32817943	2	25	from	symptoms	355:362	arg1	individuals					407:417	immunocompromised individuals	389:417	immunocompromised individuals	389:417	HCoV-NL63 is typically associated with mild upper respiratory symptoms in children, elderly and immunocompromised individuals.
32817943	2	25	from	symptoms	355:362	arg1	children					367:374	children	367:374	children	367:374	HCoV-NL63 is typically associated with mild upper respiratory symptoms in children, elderly and immunocompromised individuals.
32817943	5	26	theme	vitrified	689:697	arg1	virions					699:705	vitrified virions	689:705	vitrified virions without chemical fixative	689:731	Here we present the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative.
32817943	6	27	theme	trimer	850:855	arg1	ectodomain					824:833	the biochemically purified ectodomain	797:833	the biochemically purified ectodomain	797:833	It is structurally homologous to that obtained previously from the biochemically purified ectodomain of HCoV-NL63 S trimer, which displays a 3-fold symmetric trimer in a single conformation.
32817943	6	27	theme	trimer	850:855	arg1	trimer					850:855	HCoV-NL63 S trimer	838:855	HCoV-NL63 S trimer	838:855	It is structurally homologous to that obtained previously from the biochemically purified ectodomain of HCoV-NL63 S trimer, which displays a 3-fold symmetric trimer in a single conformation.
32817943	8	28	theme	SARS-CoV-2	1173:1182	arg1	S					1184:1184	the SARS-CoV-2 S	1169:1184	the SARS-CoV-2 S	1169:1184	The domain arrangement within a protomer is strikingly different from that of the SARS-CoV-2 S and may explain their different requirements for activating binding to the receptor.
32817943	7	29	gly	glycosylation	973:985	arg2	sites					987:991	observed glycosylation sites	964:991	observed glycosylation sites	964:991	In addition to previously proposed and observed glycosylation sites, our map shows density at other amino acid positions as well as differences in glycan structures.
32817943	5	30	theme	single-particle	654:668	arg1	imaging					678:684	single-particle cryo-EM imaging	654:684	single-particle cryo-EM imaging of vitrified virions without chemical fixative	654:731	Here we present the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative.
32817943	9	31	theme	particles	1419:1427	arg1	state					1394:1398	the native state	1383:1398	the native state of the coronavirus particles	1383:1427	This structure provides the basis for future studies of spike proteins with receptors, antibodies, or drugs, in the native state of the coronavirus particles.
32817943	0	32	theme	cryo-EM	8:14	arg1	structure					16:24	A 3.4-Å cryo-EM structure	0:24	A 3.4-Å cryo-EM structure of the human coronavirus spike trimer	0:62	A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles.
32817943	5	33	theme	cryo-EM	670:676	arg1	imaging					678:684	single-particle cryo-EM imaging	654:684	single-particle cryo-EM imaging of vitrified virions without chemical fixative	654:731	Here we present the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative.
32817943	3	34	theme	severe	452:457	arg1	illness					477:483	severe lower respiratory illness	452:483	severe lower respiratory illness	452:483	It has also been shown to cause severe lower respiratory illness.
32817943	1	35	theme	annual	264:269	arg1	diseases					283:290	all annual respiratory diseases	260:290	all annual respiratory diseases	260:290	Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases.
32817943	7	36	theme	acid	1031:1034	arg1	positions					1036:1044	other amino acid positions	1019:1044	other amino acid positions as well as differences in glycan structures	1019:1088	In addition to previously proposed and observed glycosylation sites, our map shows density at other amino acid positions as well as differences in glycan structures.
32817943	1	37	theme	family	192:197	arg1	Coronaviridae					199:211	the family Coronaviridae	188:211	the family Coronaviridae	188:211	Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases.
32817943	9	38	theme	coronavirus	1407:1417	arg1	particles					1419:1427	the coronavirus particles	1403:1427	the coronavirus particles	1403:1427	This structure provides the basis for future studies of spike proteins with receptors, antibodies, or drugs, in the native state of the coronavirus particles.
32817943	2	39	theme	immunocompromised	389:405	arg1	individuals					407:417	immunocompromised individuals	389:417	immunocompromised individuals	389:417	HCoV-NL63 is typically associated with mild upper respiratory symptoms in children, elderly and immunocompromised individuals.
32817943	1	40	theme	respiratory	271:281	arg1	diseases					283:290	all annual respiratory diseases	260:290	all annual respiratory diseases	260:290	Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases.
32817943	6	41	theme	S	848:848	arg1	trimer					850:855	HCoV-NL63 S trimer	838:855	HCoV-NL63 S trimer	838:855	It is structurally homologous to that obtained previously from the biochemically purified ectodomain of HCoV-NL63 S trimer, which displays a 3-fold symmetric trimer in a single conformation.
32817943	1	42	theme	Coronaviridae	199:211	arg1	pathogen					176:183	an enveloped pathogen	163:183	an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases	163:290	Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases.
32817943	1	42	theme	Coronaviridae	199:211	arg1	coronavirus					131:141	Human coronavirus NL63	125:146	Human coronavirus NL63 (HCoV-NL63)	125:158	Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases.
32817943	0	43	theme	coronavirus	39:49	arg1	trimer					57:62	the human coronavirus spike trimer	29:62	the human coronavirus spike trimer	29:62	A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles.
32817943	1	44	theme	diseases	283:290	arg1	diseases					283:290	all annual respiratory diseases	260:290	all annual respiratory diseases	260:290	Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases.
32817943	1	44	theme	diseases	283:290	arg1	%					255:255	up to 10%	247:255	up to 10% of all annual respiratory diseases	247:290	Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases.
32817943	7	45	theme	other	1019:1023	arg1	positions					1036:1044	other amino acid positions	1019:1044	other amino acid positions as well as differences in glycan structures	1019:1088	In addition to previously proposed and observed glycosylation sites, our map shows density at other amino acid positions as well as differences in glycan structures.
32817943	7	46	from	differences	1057:1067	arg1	density					1008:1014	density	1008:1014	density at other amino acid positions as well as differences in glycan structures	1008:1088	In addition to previously proposed and observed glycosylation sites, our map shows density at other amino acid positions as well as differences in glycan structures.
32817943	7	46	from	differences	1057:1067	arg1	structures					1079:1088	glycan structures	1072:1088	glycan structures	1072:1088	In addition to previously proposed and observed glycosylation sites, our map shows density at other amino acid positions as well as differences in glycan structures.
32817943	0	47	theme	human	33:37	arg1	trimer					57:62	the human coronavirus spike trimer	29:62	the human coronavirus spike trimer	29:62	A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles.
32817943	4	48	theme	viral	521:525	arg1	entry					527:531	viral entry	521:531	viral entry	521:531	NL63 shares ACE2 as a receptor for viral entry with SARS-CoV and SARS-CoV-2.
32817943	5	49	theme	3.4-Å	634:638	arg1	resolution					640:649	3.4-Å resolution	634:649	3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative	634:731	Here we present the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative.
32817943	5	50	dep	in	583:584	arg1	situ					586:589	situ	586:589	situ	586:589	Here we present the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative.
32817943	6	51	theme	single	904:909	arg1	conformation					911:922	a single conformation	902:922	a single conformation	902:922	It is structurally homologous to that obtained previously from the biochemically purified ectodomain of HCoV-NL63 S trimer, which displays a 3-fold symmetric trimer in a single conformation.
32817943	8	52	theme	domain	1095:1100	arg1	arrangement					1102:1112	The domain arrangement	1091:1112	The domain arrangement within a protomer	1091:1130	The domain arrangement within a protomer is strikingly different from that of the SARS-CoV-2 S and may explain their different requirements for activating binding to the receptor.
32817943	8	52	theme	domain	1095:1100	arg1	different					1146:1154	different	1146:1154	different	1146:1154	The domain arrangement within a protomer is strikingly different from that of the SARS-CoV-2 S and may explain their different requirements for activating binding to the receptor.
32817943	1	53	dep	10	253:254	arg1	to					250:251	to	250:251	to	250:251	Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases.
32817943	1	54	theme	Human	125:129	arg1	coronavirus					131:141	Human coronavirus NL63	125:146	Human coronavirus NL63 (HCoV-NL63)	125:158	Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases.
32817943	1	54	theme	Human	125:129	arg1	HCoV-NL63					149:157	HCoV-NL63	149:157	HCoV-NL63	149:157	Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases.
32817943	1	54	theme	Human	125:129	arg1	pathogen					176:183	an enveloped pathogen	163:183	an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases	163:290	Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family Coronaviridae that spreads worldwide and causes up to 10% of all annual respiratory diseases.
32817943	5	55	from	resolution	640:649	arg1	structure					591:599	the in situ structure	579:599	the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative	579:731	Here we present the in situ structure of HCoV-NL63 spike (S) trimer at 3.4-Å resolution by single-particle cryo-EM imaging of vitrified virions without chemical fixative.
32817943	6	56	theme	purified	815:822	arg1	ectodomain					824:833	the biochemically purified ectodomain	797:833	the biochemically purified ectodomain	797:833	It is structurally homologous to that obtained previously from the biochemically purified ectodomain of HCoV-NL63 S trimer, which displays a 3-fold symmetric trimer in a single conformation.
32817943	6	56	theme	purified	815:822	arg1	trimer					850:855	HCoV-NL63 S trimer	838:855	HCoV-NL63 S trimer	838:855	It is structurally homologous to that obtained previously from the biochemically purified ectodomain of HCoV-NL63 S trimer, which displays a 3-fold symmetric trimer in a single conformation.
32817943	7	57	theme	glycosylation	973:985	arg1	sites					987:991	observed glycosylation sites	964:991	observed glycosylation sites	964:991	In addition to previously proposed and observed glycosylation sites, our map shows density at other amino acid positions as well as differences in glycan structures.
32817943	0	58	theme	trimer	57:62	arg1	structure					16:24	A 3.4-Å cryo-EM structure	0:24	A 3.4-Å cryo-EM structure of the human coronavirus spike trimer	0:62	A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles.
32817943	8	59	from	that	1161:1164	arg1	arrangement					1102:1112	The domain arrangement	1091:1112	The domain arrangement within a protomer	1091:1130	The domain arrangement within a protomer is strikingly different from that of the SARS-CoV-2 S and may explain their different requirements for activating binding to the receptor.
32817943	8	59	from	that	1161:1164	arg1	different					1146:1154	different	1146:1154	different	1146:1154	The domain arrangement within a protomer is strikingly different from that of the SARS-CoV-2 S and may explain their different requirements for activating binding to the receptor.
32817943	0	60	theme	spike	51:55	arg1	trimer					57:62	the human coronavirus spike trimer	29:62	the human coronavirus spike trimer	29:62	A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles.
32817943	3	61	dep	severe	452:457	arg1	respiratory					465:475	respiratory	465:475	respiratory	465:475	It has also been shown to cause severe lower respiratory illness.
32817943	2	62	theme	respiratory	343:353	arg1	symptoms					355:362	mild upper respiratory symptoms	332:362	mild upper respiratory symptoms in children, elderly and immunocompromised individuals	332:417	HCoV-NL63 is typically associated with mild upper respiratory symptoms in children, elderly and immunocompromised individuals.
32806321	2	0	theme	C1-C2-0-CI	474:483	arg1	"					-1:-1		474:-1		474:-1	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	2	0	theme	C1-C2-0-CI	474:483	arg1	ϴ					471:471	ϴ	471:471	ϴ	471:471	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	5	1	with	structure	838:846	arg1	stability					865:873	the thermal stability	853:873	the thermal stability directly proportional to the increase in drug uptake	853:926	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	1	2	theme	carbon	159:164	arg1	source					166:171	an external carbon source	147:171	an external carbon source	147:171	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
32806321	1	3	theme	drug	330:333	arg1	delivery					335:342	drug delivery	330:342	drug delivery	330:342	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
32806321	3	4	theme	successful	585:594	arg1	inactivation					596:607	a successful inactivation	583:607	a successful inactivation of Staphylococcus aureus and Escherichia coli in the presence of photons	583:680	A bacterial susceptibility test revealed a successful inactivation of Staphylococcus aureus and Escherichia coli in the presence of photons.
32806321	1	5	theme	bacterial	251:259	arg1	strain					261:266	Gluconacetobacter xylinus (ATCC 10245) bacterial strain	212:266	Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets	212:314	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
32806321	2	6	theme	C2-0-C	492:497	arg1	ϴ					489:489	ϴ	489:489	ϴ	489:489	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	2	6	theme	C2-0-C	492:497	arg1	1'-C2					499:503	C2-0-C 1'-C2'	492:504	C2-0-C 1'-C2'	492:504	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	5	7	from	increase	939:946	arg1	degree					955:960	the degree	951:960	the degree of polymerization	951:978	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	4	8	dep	Fourier	683:689	arg1	Transform					691:699	Transform	691:699	Transform Infrared Spectroscopy analysis confirmed an OH absorption	691:757	Fourier Transform Infrared Spectroscopy analysis confirmed an OH absorption was verified at 3423 cm-1.
32806321	3	9	theme	coli	650:653	arg1	inactivation					596:607	a successful inactivation	583:607	a successful inactivation of Staphylococcus aureus and Escherichia coli in the presence of photons	583:680	A bacterial susceptibility test revealed a successful inactivation of Staphylococcus aureus and Escherichia coli in the presence of photons.
32806321	2	10	theme	ϴ	489:489	arg1	ϕ = Ψ = ω = 180°					430:445	ϕ = Ψ = ω = 180°	430:445	ϕ = Ψ = ω = 180°	430:445	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	2	10	theme	ϴ	489:489	arg1	rotation					459:466	angular rotation	451:466	angular rotation	451:466	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	2	11	theme	inulobiose	378:387	arg1	conformation					395:406	inulobiose trans conformation	378:406	inulobiose trans conformation	378:406	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	5	12	from	increase	904:911	arg1	uptake					921:926	drug uptake	916:926	drug uptake	916:926	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	4	13	theme	OH	745:746	arg1	absorption					748:757	an OH absorption	742:757	an OH absorption	742:757	Fourier Transform Infrared Spectroscopy analysis confirmed an OH absorption was verified at 3423 cm-1.
32806321	3	14	from	inactivation	596:607	arg1	presence					662:669	the presence	658:669	the presence of photons	658:680	A bacterial susceptibility test revealed a successful inactivation of Staphylococcus aureus and Escherichia coli in the presence of photons.
32806321	0	15	theme	OH-radical	12:21	arg1	cellulosic					37:46	Synthesized OH-radical rich bacteria cellulosic	0:46	Synthesized OH-radical rich bacteria cellulosic	0:46	Synthesized OH-radical rich bacteria cellulosic pockets with photodynamic bacteria inactivation properties against S. ureus and E. coli.
32806321	3	16	theme	photons	674:680	arg1	presence					662:669	the presence	658:669	the presence of photons	658:680	A bacterial susceptibility test revealed a successful inactivation of Staphylococcus aureus and Escherichia coli in the presence of photons.
32806321	5	17	theme	polymerization	965:978	arg1	degree					955:960	the degree	951:960	the degree of polymerization	951:978	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	4	18	theme	Infrared	701:708	arg1	Spectroscopy					710:721	Infrared Spectroscopy	701:721	Infrared Spectroscopy	701:721	Fourier Transform Infrared Spectroscopy analysis confirmed an OH absorption was verified at 3423 cm-1.
32806321	0	19	theme	Synthesized	0:10	arg1	cellulosic					37:46	Synthesized OH-radical rich bacteria cellulosic	0:46	Synthesized OH-radical rich bacteria cellulosic	0:46	Synthesized OH-radical rich bacteria cellulosic pockets with photodynamic bacteria inactivation properties against S. ureus and E. coli.
32806321	3	20	theme	aureus	627:632	arg1	inactivation					596:607	a successful inactivation	583:607	a successful inactivation of Staphylococcus aureus and Escherichia coli in the presence of photons	583:680	A bacterial susceptibility test revealed a successful inactivation of Staphylococcus aureus and Escherichia coli in the presence of photons.
32806321	5	21	theme	Pocket	786:791	arg1	uptake					798:803	Pocket drug uptake	786:803	Pocket drug uptake test	786:808	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	5	22	from	increase	996:1003	arg1	rate					1033:1036	rate	1033:1036	rate	1033:1036	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	5	22	from	increase	996:1003	arg1	activity					1020:1027	antioxidant activity	1008:1027	antioxidant activity	1008:1027	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	0	23	theme	bacteria	28:35	arg1	cellulosic					37:46	Synthesized OH-radical rich bacteria cellulosic	0:46	Synthesized OH-radical rich bacteria cellulosic	0:46	Synthesized OH-radical rich bacteria cellulosic pockets with photodynamic bacteria inactivation properties against S. ureus and E. coli.
32806321	1	24	dep	fructose	189:196	arg1	substitute					198:207	substitute	198:207	substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage	198:354	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
32806321	1	25	from	strain	261:266	arg1	synthesis					284:292	a successful synthesis	271:292	a successful synthesis of cellulosic pockets	271:314	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
32806321	0	26	theme	rich	23:26	arg1	cellulosic					37:46	Synthesized OH-radical rich bacteria cellulosic	0:46	Synthesized OH-radical rich bacteria cellulosic	0:46	Synthesized OH-radical rich bacteria cellulosic pockets with photodynamic bacteria inactivation properties against S. ureus and E. coli.
32806321	5	27	theme	proportional	884:895	arg1	stability					865:873	the thermal stability	853:873	the thermal stability directly proportional to the increase in drug uptake	853:926	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	6	28	theme	cellular	1125:1132	arg1	activity					1134:1141	cellular activity	1125:1141	cellular activity	1125:1141	HYPOTHESIS: Inulin as an inert polysaccharide is neutral to cellular activity, therefore, could not be an agent for bacteria inactivation.
32806321	2	29	theme	ϴ	471:471	arg1	ϕ = Ψ = ω = 180°					430:445	ϕ = Ψ = ω = 180°	430:445	ϕ = Ψ = ω = 180°	430:445	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	2	29	theme	ϴ	471:471	arg1	rotation					459:466	angular rotation	451:466	angular rotation	451:466	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	5	30	theme	bacterial	1041:1049	arg1	inactivation					1051:1062	bacterial inactivation	1041:1062	bacterial inactivation	1041:1062	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	5	31	theme	absorbent	828:836	arg1	structure					838:846	a highly absorbent structure	819:846	a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake	819:926	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	1	32	theme	cellulosic	297:306	arg1	pockets					308:314	cellulosic pockets	297:314	cellulosic pockets	297:314	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
32806321	5	33	theme	inactivation	1051:1062	arg1	rate					1033:1036	rate	1033:1036	rate	1033:1036	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	5	33	theme	inactivation	1051:1062	arg1	activity					1020:1027	antioxidant activity	1008:1027	antioxidant activity	1008:1027	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	5	34	theme	drug	793:796	arg1	uptake					798:803	Pocket drug uptake	786:803	Pocket drug uptake test	786:808	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	1	35	theme	Gluconacetobacter	212:228	arg1	strain					261:266	Gluconacetobacter xylinus (ATCC 10245) bacterial strain	212:266	Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets	212:314	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
32806321	0	36	theme	photodynamic	61:72	arg1	properties					96:105	photodynamic bacteria inactivation properties	61:105	photodynamic bacteria inactivation properties against S. ureus and E. coli	61:134	Synthesized OH-radical rich bacteria cellulosic pockets with photodynamic bacteria inactivation properties against S. ureus and E. coli.
32806321	1	37	theme	pockets	308:314	arg1	synthesis					284:292	a successful synthesis	271:292	a successful synthesis of cellulosic pockets	271:314	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
32806321	1	38	theme	successful	273:282	arg1	synthesis					284:292	a successful synthesis	271:292	a successful synthesis of cellulosic pockets	271:314	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
32806321	6	39	theme	bacteria	1181:1188	arg1	inactivation					1190:1201	bacteria inactivation	1181:1201	bacteria inactivation	1181:1201	HYPOTHESIS: Inulin as an inert polysaccharide is neutral to cellular activity, therefore, could not be an agent for bacteria inactivation.
32806321	2	40	with	agreement	415:423	arg1	ϕ = Ψ = ω = 180°					430:445	ϕ = Ψ = ω = 180°	430:445	ϕ = Ψ = ω = 180°	430:445	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	2	40	with	agreement	415:423	arg1	rotation					459:466	angular rotation	451:466	angular rotation	451:466	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	2	41	theme	angular	451:457	arg1	rotation					459:466	angular rotation	451:466	angular rotation	451:466	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	5	42	theme	antioxidant	1008:1018	arg1	activity					1020:1027	antioxidant activity	1008:1027	antioxidant activity	1008:1027	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	5	43	theme	drug	916:919	arg1	uptake					921:926	drug uptake	916:926	drug uptake	916:926	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	6	44	dep	HYPOTHESIS	1065:1074	arg1	Inulin					1077:1082	Inulin	1077:1082	HYPOTHESIS: Inulin	1065:1082	HYPOTHESIS: Inulin as an inert polysaccharide is neutral to cellular activity, therefore, could not be an agent for bacteria inactivation.
32806321	6	45	theme	inert	1090:1094	arg1	neutral					1114:1120	neutral	1114:1120	neutral	1114:1120	HYPOTHESIS: Inulin as an inert polysaccharide is neutral to cellular activity, therefore, could not be an agent for bacteria inactivation.
32806321	6	45	theme	inert	1090:1094	arg1	polysaccharide					1096:1109	an inert polysaccharide	1087:1109	an inert polysaccharide	1087:1109	HYPOTHESIS: Inulin as an inert polysaccharide is neutral to cellular activity, therefore, could not be an agent for bacteria inactivation.
32806321	3	46	theme	bacterial	544:552	arg1	test					569:572	A bacterial susceptibility test	542:572	A bacterial susceptibility test	542:572	A bacterial susceptibility test revealed a successful inactivation of Staphylococcus aureus and Escherichia coli in the presence of photons.
32806321	1	47	theme	xylinus	230:236	arg1	strain					261:266	Gluconacetobacter xylinus (ATCC 10245) bacterial strain	212:266	Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets	212:314	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
32806321	2	48	theme	ϴ	511:511	arg1	ϕ = Ψ = ω = 180°					430:445	ϕ = Ψ = ω = 180°	430:445	ϕ = Ψ = ω = 180°	430:445	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	2	48	theme	ϴ	511:511	arg1	rotation					459:466	angular rotation	451:466	angular rotation	451:466	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	5	49	theme	uptake	798:803	arg1	test					805:808	Pocket drug uptake test	786:808	Pocket drug uptake test	786:808	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	4	50	dep	Transform	691:699	arg1	confirmed					732:740	confirmed	732:740	confirmed an OH absorption	732:757	Fourier Transform Infrared Spectroscopy analysis confirmed an OH absorption was verified at 3423 cm-1.
32806321	6	51	dep	agent	1171:1175	arg1	neutral					1114:1120	neutral	1114:1120	neutral	1114:1120	HYPOTHESIS: Inulin as an inert polysaccharide is neutral to cellular activity, therefore, could not be an agent for bacteria inactivation.
32806321	6	51	dep	agent	1171:1175	arg1	polysaccharide					1096:1109	an inert polysaccharide	1087:1109	an inert polysaccharide	1087:1109	HYPOTHESIS: Inulin as an inert polysaccharide is neutral to cellular activity, therefore, could not be an agent for bacteria inactivation.
32806321	0	52	theme	inactivation	83:94	arg1	properties					96:105	photodynamic bacteria inactivation properties	61:105	photodynamic bacteria inactivation properties against S. ureus and E. coli	61:134	Synthesized OH-radical rich bacteria cellulosic pockets with photodynamic bacteria inactivation properties against S. ureus and E. coli.
32806321	2	53	theme	trans	389:393	arg1	conformation					395:406	inulobiose trans conformation	378:406	inulobiose trans conformation	378:406	It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI''), ϴ (C2-0-C 1'-C2') and ϴ (0-C1'-C2'-0') respectively.
32806321	1	54	used	used	177:180	arg2	fructose					189:196	the fructose	185:196	the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage	185:354	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
32806321	1	54	used	used	177:180	arg2	Inulin					137:142	Inulin	137:142	Inulin as an external carbon source	137:171	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
32806321	5	55	theme	thermal	857:863	arg1	stability					865:873	the thermal stability	853:873	the thermal stability directly proportional to the increase in drug uptake	853:926	Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
32806321	1	56	theme	ATCC	239:242	arg1	strain					261:266	Gluconacetobacter xylinus (ATCC 10245) bacterial strain	212:266	Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets	212:314	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
32806321	0	57	theme	bacteria	74:81	arg1	properties					96:105	photodynamic bacteria inactivation properties	61:105	photodynamic bacteria inactivation properties against S. ureus and E. coli	61:134	Synthesized OH-radical rich bacteria cellulosic pockets with photodynamic bacteria inactivation properties against S. ureus and E. coli.
32806321	3	58	theme	susceptibility	554:567	arg1	test					569:572	A bacterial susceptibility test	542:572	A bacterial susceptibility test	542:572	A bacterial susceptibility test revealed a successful inactivation of Staphylococcus aureus and Escherichia coli in the presence of photons.
32806321	1	59	theme	external	150:157	arg1	source					166:171	an external carbon source	147:171	an external carbon source	147:171	Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage.
33541667	6	0	theme	conductive	1138:1147	arg1	films					1158:1162	conductive BC/PEDOT films	1138:1162	conductive BC/PEDOT films	1138:1162	Moreover, bent BC/PEDOT films enable operation of a green light-emitting diode (LED) light, indicating the flexibility and stability of conductive BC/PEDOT films.
33541667	4	1	theme	10	755:756	arg1	times					758:762	times	758:762	times	758:762	We demonstrate that vapor phase polymerized BC/PEDOT composites exhibit more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square).
33541667	3	2	theme	flexible	547:554	arg1	matrix					556:561	a flexible matrix	545:561	a flexible matrix	545:561	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	3	2	theme	flexible	547:554	arg1	cellulose					519:527	Eco-friendly bacterial cellulose	496:527	Eco-friendly bacterial cellulose (BC)	496:532	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	7	3	theme	flexible	1242:1249	arg1	films					1281:1285	eco-friendly, flexible, and conductive nanocomposite films	1228:1285	eco-friendly, flexible, and conductive nanocomposite films	1228:1285	Overall, this study suggests a strategy for the development of eco-friendly, flexible, and conductive nanocomposite films.
33541667	6	4	dep	flexibility	1109:1119	arg1	the					1105:1107	the	1105:1107	the	1105:1107	Moreover, bent BC/PEDOT films enable operation of a green light-emitting diode (LED) light, indicating the flexibility and stability of conductive BC/PEDOT films.
33541667	3	5	theme	conductive	579:588	arg1	polymer					596:602	the highly conductive PEDOT polymer	568:602	the highly conductive PEDOT polymer	568:602	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	4	6	theme	polymerized	705:715	arg1	composites					726:735	vapor phase polymerized BC/PEDOT composites	693:735	vapor phase polymerized BC/PEDOT composites	693:735	We demonstrate that vapor phase polymerized BC/PEDOT composites exhibit more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square).
33541667	4	7	dep	resistance	776:785	arg1	times					758:762	times	758:762	times	758:762	We demonstrate that vapor phase polymerized BC/PEDOT composites exhibit more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square).
33541667	3	8	theme	PEDOT	590:594	arg1	polymer					596:602	the highly conductive PEDOT polymer	568:602	the highly conductive PEDOT polymer	568:602	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	7	9	theme	nanocomposite	1267:1279	arg1	films					1281:1285	eco-friendly, flexible, and conductive nanocomposite films	1228:1285	eco-friendly, flexible, and conductive nanocomposite films	1228:1285	Overall, this study suggests a strategy for the development of eco-friendly, flexible, and conductive nanocomposite films.
33541667	2	10	theme	self-standing	335:347	arg1	nanocomposites					430:443	flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites	325:443	flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method	325:493	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	5	11	theme	notable	958:964	arg1	decrease					966:973	a notable decrease	956:973	a notable decrease in electronic performance	956:999	The resultant BC/PEDOT fabricated could be bent up to 100 times and completely rolled up without a notable decrease in electronic performance.
33541667	4	12	theme	polymerized	822:832	arg1	BC/PEDOT					834:841	solution polymerized BC/PEDOT	813:841	solution polymerized BC/PEDOT (188 Ω/square)	813:856	We demonstrate that vapor phase polymerized BC/PEDOT composites exhibit more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square).
33541667	4	12	theme	polymerized	822:832	arg1	Ω/square					848:855	188 Ω/square	844:855	188 Ω/square	844:855	We demonstrate that vapor phase polymerized BC/PEDOT composites exhibit more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square).
33541667	1	13	theme	effective	207:215	arg1	attention					191:199	attention	191:199	attention	191:199	Eco-friendly conductive polymer nanocomposites have garnered attention as an effective alternative for conventional conductive nanocomposites.
33541667	1	13	theme	effective	207:215	arg1	alternative					217:227	an effective alternative	204:227	an effective alternative for conventional conductive nanocomposites	204:270	Eco-friendly conductive polymer nanocomposites have garnered attention as an effective alternative for conventional conductive nanocomposites.
33541667	6	14	theme	BC/PEDOT	1017:1024	arg1	films					1026:1030	bent BC/PEDOT films	1012:1030	bent BC/PEDOT films	1012:1030	Moreover, bent BC/PEDOT films enable operation of a green light-emitting diode (LED) light, indicating the flexibility and stability of conductive BC/PEDOT films.
33541667	2	15	theme	flexible	325:332	arg1	nanocomposites					430:443	flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites	325:443	flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method	325:493	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	2	16	theme	vapor	455:459	arg1	method					488:493	the vapor phase polymerization (VPP) method	451:493	the vapor phase polymerization (VPP) method	451:493	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	0	17	theme	phase	6:10	arg1	polymerization					12:25	Vapor phase polymerization	0:25	Vapor phase polymerization for electronically conductive nanopaper	0:65	Vapor phase polymerization for electronically conductive nanopaper based on bacterial cellulose/poly(3,4-ethylenedioxythiophene).
33541667	4	18	theme	phase	699:703	arg1	composites					726:735	vapor phase polymerized BC/PEDOT composites	693:735	vapor phase polymerized BC/PEDOT composites	693:735	We demonstrate that vapor phase polymerized BC/PEDOT composites exhibit more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square).
33541667	2	19	theme	cellulose/poly	375:388	arg1	nanocomposites					430:443	flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites	325:443	flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method	325:493	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	0	20	theme	Vapor	0:4	arg1	polymerization					12:25	Vapor phase polymerization	0:25	Vapor phase polymerization for electronically conductive nanopaper	0:65	Vapor phase polymerization for electronically conductive nanopaper based on bacterial cellulose/poly(3,4-ethylenedioxythiophene).
33541667	6	21	theme	bent	1012:1015	arg1	films					1026:1030	bent BC/PEDOT films	1012:1030	bent BC/PEDOT films	1012:1030	Moreover, bent BC/PEDOT films enable operation of a green light-emitting diode (LED) light, indicating the flexibility and stability of conductive BC/PEDOT films.
33541667	2	22	theme	bacterial	365:373	arg1	dioxythiophene					403:416	3,4-ethylene dioxythiophene	390:416	3,4-ethylene dioxythiophene	390:416	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	2	22	theme	bacterial	365:373	arg1	BC/PEDOT					420:427	BC/PEDOT	420:427	BC/PEDOT	420:427	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	2	22	theme	bacterial	365:373	arg1	cellulose/poly					375:388	bacterial cellulose/poly	365:388	flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method	325:493	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	4	23	dep	times	758:762	arg1	lower					764:768	lower	764:768	lower	764:768	We demonstrate that vapor phase polymerized BC/PEDOT composites exhibit more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square).
33541667	1	24	theme	conventional	233:244	arg1	nanocomposites					257:270	conventional conductive nanocomposites	233:270	conventional conductive nanocomposites	233:270	Eco-friendly conductive polymer nanocomposites have garnered attention as an effective alternative for conventional conductive nanocomposites.
33541667	2	25	theme	conductive	354:363	arg1	nanocomposites					430:443	flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites	325:443	flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method	325:493	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	1	26	theme	conductive	246:255	arg1	nanocomposites					257:270	conventional conductive nanocomposites	233:270	conventional conductive nanocomposites	233:270	Eco-friendly conductive polymer nanocomposites have garnered attention as an effective alternative for conventional conductive nanocomposites.
33541667	5	27	theme	resultant	863:871	arg1	BC/PEDOT					873:880	The resultant BC/PEDOT	859:880	The resultant BC/PEDOT fabricated	859:891	The resultant BC/PEDOT fabricated could be bent up to 100 times and completely rolled up without a notable decrease in electronic performance.
33541667	5	27	theme	resultant	863:871	arg1	times					917:921	up to 100 times	907:921	up to 100 times	907:921	The resultant BC/PEDOT fabricated could be bent up to 100 times and completely rolled up without a notable decrease in electronic performance.
33541667	5	27	theme	resultant	863:871	arg1	bent					902:905	bent	902:905	bent	902:905	The resultant BC/PEDOT fabricated could be bent up to 100 times and completely rolled up without a notable decrease in electronic performance.
33541667	6	28	dep	diode	1075:1079	arg1	LED					1082:1084	LED	1082:1084	LED	1082:1084	Moreover, bent BC/PEDOT films enable operation of a green light-emitting diode (LED) light, indicating the flexibility and stability of conductive BC/PEDOT films.
33541667	1	29	theme	Eco-friendly	130:141	arg1	nanocomposites					162:175	Eco-friendly conductive polymer nanocomposites	130:175	Eco-friendly conductive polymer nanocomposites	130:175	Eco-friendly conductive polymer nanocomposites have garnered attention as an effective alternative for conventional conductive nanocomposites.
33541667	2	30	theme	VPP	483:485	arg1	method					488:493	the vapor phase polymerization (VPP) method	451:493	the vapor phase polymerization (VPP) method	451:493	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	0	31	theme	conductive	46:55	arg1	nanopaper					57:65	electronically conductive nanopaper	31:65	electronically conductive nanopaper	31:65	Vapor phase polymerization for electronically conductive nanopaper based on bacterial cellulose/poly(3,4-ethylenedioxythiophene).
33541667	6	32	theme	films	1158:1162	arg1	stability					1125:1133	stability	1125:1133	stability	1125:1133	Moreover, bent BC/PEDOT films enable operation of a green light-emitting diode (LED) light, indicating the flexibility and stability of conductive BC/PEDOT films.
33541667	6	32	theme	films	1158:1162	arg1	flexibility					1109:1119	flexibility	1109:1119	flexibility	1109:1119	Moreover, bent BC/PEDOT films enable operation of a green light-emitting diode (LED) light, indicating the flexibility and stability of conductive BC/PEDOT films.
33541667	7	33	theme	films	1281:1285	arg1	development					1213:1223	the development	1209:1223	the development of eco-friendly, flexible, and conductive nanocomposite films	1209:1285	Overall, this study suggests a strategy for the development of eco-friendly, flexible, and conductive nanocomposite films.
33541667	3	34	used	used	537:540	arg2	matrix					556:561	a flexible matrix	545:561	a flexible matrix	545:561	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	3	34	used	used	537:540	arg2	BC					530:531	BC	530:531	BC	530:531	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	3	34	used	used	537:540	arg2	cellulose					519:527	Eco-friendly bacterial cellulose	496:527	Eco-friendly bacterial cellulose (BC)	496:532	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	4	35	theme	BC/PEDOT	717:724	arg1	composites					726:735	vapor phase polymerized BC/PEDOT composites	693:735	vapor phase polymerized BC/PEDOT composites	693:735	We demonstrate that vapor phase polymerized BC/PEDOT composites exhibit more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square).
33541667	4	36	theme	vapor	693:697	arg1	composites					726:735	vapor phase polymerized BC/PEDOT composites	693:735	vapor phase polymerized BC/PEDOT composites	693:735	We demonstrate that vapor phase polymerized BC/PEDOT composites exhibit more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square).
33541667	2	37	theme	phase	461:465	arg1	method					488:493	the vapor phase polymerization (VPP) method	451:493	the vapor phase polymerization (VPP) method	451:493	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	5	38	dep	100	913:915	arg1	to					910:911	to	910:911	to	910:911	The resultant BC/PEDOT fabricated could be bent up to 100 times and completely rolled up without a notable decrease in electronic performance.
33541667	2	39	theme	polymerization	467:480	arg1	method					488:493	the vapor phase polymerization (VPP) method	451:493	the vapor phase polymerization (VPP) method	451:493	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	3	40	theme	Eco-friendly	496:507	arg1	matrix					556:561	a flexible matrix	545:561	a flexible matrix	545:561	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	3	40	theme	Eco-friendly	496:507	arg1	BC					530:531	BC	530:531	BC	530:531	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	3	40	theme	Eco-friendly	496:507	arg1	cellulose					519:527	Eco-friendly bacterial cellulose	496:527	Eco-friendly bacterial cellulose (BC)	496:532	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	5	41	dep	bent	902:905	arg1	times					917:921	up to 100 times	907:921	up to 100 times	907:921	The resultant BC/PEDOT fabricated could be bent up to 100 times and completely rolled up without a notable decrease in electronic performance.
33541667	5	41	dep	bent	902:905	arg1	BC/PEDOT					873:880	The resultant BC/PEDOT	859:880	The resultant BC/PEDOT fabricated	859:891	The resultant BC/PEDOT fabricated could be bent up to 100 times and completely rolled up without a notable decrease in electronic performance.
33541667	5	41	dep	bent	902:905	arg1	bent					902:905	bent	902:905	bent	902:905	The resultant BC/PEDOT fabricated could be bent up to 100 times and completely rolled up without a notable decrease in electronic performance.
33541667	1	42	theme	conductive	143:152	arg1	nanocomposites					162:175	Eco-friendly conductive polymer nanocomposites	130:175	Eco-friendly conductive polymer nanocomposites	130:175	Eco-friendly conductive polymer nanocomposites have garnered attention as an effective alternative for conventional conductive nanocomposites.
33541667	3	43	theme	BC	627:628	arg1	matrix					630:635	the BC matrix	623:635	the BC matrix	623:635	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	1	44	theme	polymer	154:160	arg1	nanocomposites					162:175	Eco-friendly conductive polymer nanocomposites	130:175	Eco-friendly conductive polymer nanocomposites	130:175	Eco-friendly conductive polymer nanocomposites have garnered attention as an effective alternative for conventional conductive nanocomposites.
33541667	6	45	theme	green	1054:1058	arg1	diode					1075:1079	a green light-emitting diode	1052:1079	a green light-emitting diode (LED) light	1052:1091	Moreover, bent BC/PEDOT films enable operation of a green light-emitting diode (LED) light, indicating the flexibility and stability of conductive BC/PEDOT films.
33541667	2	46	theme	3,4-ethylene	390:401	arg1	dioxythiophene					403:416	3,4-ethylene dioxythiophene	390:416	3,4-ethylene dioxythiophene	390:416	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	2	46	theme	3,4-ethylene	390:401	arg1	cellulose/poly					375:388	bacterial cellulose/poly	365:388	flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method	325:493	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	5	47	theme	electronic	978:987	arg1	performance					989:999	electronic performance	978:999	electronic performance	978:999	The resultant BC/PEDOT fabricated could be bent up to 100 times and completely rolled up without a notable decrease in electronic performance.
33541667	6	48	theme	light-emitting	1060:1073	arg1	diode					1075:1079	a green light-emitting diode	1052:1079	a green light-emitting diode (LED) light	1052:1091	Moreover, bent BC/PEDOT films enable operation of a green light-emitting diode (LED) light, indicating the flexibility and stability of conductive BC/PEDOT films.
33541667	4	49	theme	solution	813:820	arg1	BC/PEDOT					834:841	solution polymerized BC/PEDOT	813:841	solution polymerized BC/PEDOT (188 Ω/square)	813:856	We demonstrate that vapor phase polymerized BC/PEDOT composites exhibit more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square).
33541667	4	49	theme	solution	813:820	arg1	Ω/square					848:855	188 Ω/square	844:855	188 Ω/square	844:855	We demonstrate that vapor phase polymerized BC/PEDOT composites exhibit more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square).
33541667	6	50	theme	light	1087:1091	arg1	operation					1039:1047	operation	1039:1047	operation of a green light-emitting diode (LED) light	1039:1091	Moreover, bent BC/PEDOT films enable operation of a green light-emitting diode (LED) light, indicating the flexibility and stability of conductive BC/PEDOT films.
33541667	4	51	theme	sheet	770:774	arg1	Ω/square					791:798	18 Ω/square	788:798	18 Ω/square	788:798	We demonstrate that vapor phase polymerized BC/PEDOT composites exhibit more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square).
33541667	4	51	theme	sheet	770:774	arg1	resistance					776:785	more than 10 times lower sheet resistance	745:785	more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square)	745:856	We demonstrate that vapor phase polymerized BC/PEDOT composites exhibit more than 10 times lower sheet resistance (18 Ω/square) compared to solution polymerized BC/PEDOT (188 Ω/square).
33541667	5	52	from	decrease	966:973	arg1	performance					989:999	electronic performance	978:999	electronic performance	978:999	The resultant BC/PEDOT fabricated could be bent up to 100 times and completely rolled up without a notable decrease in electronic performance.
33541667	6	53	theme	BC/PEDOT	1149:1156	arg1	films					1158:1162	conductive BC/PEDOT films	1138:1162	conductive BC/PEDOT films	1138:1162	Moreover, bent BC/PEDOT films enable operation of a green light-emitting diode (LED) light, indicating the flexibility and stability of conductive BC/PEDOT films.
33541667	0	54	theme	bacterial	76:84	arg1	cellulose/poly					86:99	bacterial cellulose/poly	76:99	bacterial cellulose/poly(3,4-ethylenedioxythiophene)	76:127	Vapor phase polymerization for electronically conductive nanopaper based on bacterial cellulose/poly(3,4-ethylenedioxythiophene).
33541667	0	54	theme	bacterial	76:84	arg1	3,4-ethylenedioxythiophene					101:126	3,4-ethylenedioxythiophene	101:126	3,4-ethylenedioxythiophene	101:126	Vapor phase polymerization for electronically conductive nanopaper based on bacterial cellulose/poly(3,4-ethylenedioxythiophene).
33541667	6	55	theme	diode	1075:1079	arg1	light					1087:1091	a green light-emitting diode (LED) light	1052:1091	a green light-emitting diode (LED) light	1052:1091	Moreover, bent BC/PEDOT films enable operation of a green light-emitting diode (LED) light, indicating the flexibility and stability of conductive BC/PEDOT films.
33541667	2	56	theme	nanocomposites	430:443	arg1	optimization					309:320	optimization	309:320	optimization	309:320	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	2	56	theme	nanocomposites	430:443	arg1	fabrication					293:303	the fabrication	289:303	the fabrication	289:303	Here, we report the fabrication and optimization of flexible, self-standing, and conductive bacterial cellulose/poly(3,4-ethylene dioxythiophene) (BC/PEDOT) nanocomposites using the vapor phase polymerization (VPP) method.
33541667	3	57	theme	bacterial	509:517	arg1	matrix					556:561	a flexible matrix	545:561	a flexible matrix	545:561	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	3	57	theme	bacterial	509:517	arg1	BC					530:531	BC	530:531	BC	530:531	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	3	57	theme	bacterial	509:517	arg1	cellulose					519:527	Eco-friendly bacterial cellulose	496:527	Eco-friendly bacterial cellulose (BC)	496:532	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	3	58	theme	electronic	648:657	arg1	conductivity					659:670	electronic conductivity	648:670	electronic conductivity	648:670	Eco-friendly bacterial cellulose (BC) is used as a flexible matrix, and the highly conductive PEDOT polymer is introduced into the BC matrix to achieve electronic conductivity.
33541667	7	59	theme	conductive	1256:1265	arg1	films					1281:1285	eco-friendly, flexible, and conductive nanocomposite films	1228:1285	eco-friendly, flexible, and conductive nanocomposite films	1228:1285	Overall, this study suggests a strategy for the development of eco-friendly, flexible, and conductive nanocomposite films.
33541667	7	60	theme	eco-friendly	1228:1239	arg1	films					1281:1285	eco-friendly, flexible, and conductive nanocomposite films	1228:1285	eco-friendly, flexible, and conductive nanocomposite films	1228:1285	Overall, this study suggests a strategy for the development of eco-friendly, flexible, and conductive nanocomposite films.
33023379	6	0	dep	gelatin	909:915	arg1	SIS					986:988	SIS	986:988	SIS (GS:HA:SIS)	986:1000	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	6	0	dep	gelatin	909:915	arg1	acid					943:946	hyaluronic acid	932:946	hyaluronic acid (GS:HA)	932:954	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	6	0	dep	gelatin	909:915	arg1	GS					991:992	GS	991:992	GS:HA:SIS	991:999	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	6	0	dep	gelatin	909:915	arg1	gelatin					960:966	gelatin	960:966	gelatin	960:966	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	6	0	dep	gelatin	909:915	arg1	acid					980:983	hyaluronic acid	969:983	hyaluronic acid	969:983	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	6	0	dep	gelatin	909:915	arg1	HA					952:953	GS:HA	949:953	GS:HA	949:953	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	7	1	theme	SIS	1013:1015	arg1	sponges					1017:1023	HA:SIS sponges	1010:1023	HA:SIS sponges	1010:1023	The GS:HA:SIS sponges underwent a 24.8 ± 5.4% weight loss in a 7-day in vitro erosion test.
33023379	9	2	theme	12-day	1259:1264	arg1	experiment					1274:1283	a 12-day in vivo experiment	1257:1283	a 12-day in vivo experiment	1257:1283	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	9	3	theme	vessel	1457:1462	arg1	formation					1464:1472	capillary vessel formation	1447:1472	capillary vessel formation	1447:1472	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	7	4	theme	HA	1010:1011	arg1	sponges					1017:1023	HA:SIS sponges	1010:1023	HA:SIS sponges	1010:1023	The GS:HA:SIS sponges underwent a 24.8 ± 5.4% weight loss in a 7-day in vitro erosion test.
33023379	6	5	theme	crosslinked	810:820	arg1	sponges					822:828	Glutaraldehyde crosslinked sponges	795:828	Glutaraldehyde crosslinked sponges of three different compositions	795:860	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	2	6	theme	traumatic	273:281	arg1	amputations					288:298	non traumatic foot amputations	269:298	non traumatic foot amputations	269:298	Diabetes comes first among the reasons of non traumatic foot amputations.
33023379	6	7	theme	rat	898:900	arg1	model					902:906	a diabetic rat model	887:906	a diabetic rat model	887:906	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	1	8	theme	foot	171:174	arg1	wounds					176:181	diabetic foot wounds	162:181	diabetic foot wounds	162:181	Despite the fast development of technology in the world, diabetic foot wounds cause deaths and massive economical losses.
33023379	9	9	theme	foreign	1479:1485	arg1	P > 0.05					1502:1509	P > 0.05	1502:1509	P > 0.05	1502:1509	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	9	9	theme	foreign	1479:1485	arg1	reaction					1492:1499	foreign body reaction	1479:1499	foreign body reaction (P > 0.05)	1479:1510	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	8	10	theme	similar	1113:1119	arg1	modulus					1129:1135	a similar Young's modulus	1111:1135	a similar Young's modulus	1111:1135	All sponges had a similar Young's modulus under compression but GS:HA:SIS had the highest (5.00 ± 0.04 kPa).
33023379	11	11	theme	submucosa	1770:1778	arg1	ECM					1740:1742	the ECM	1736:1742	the ECM of sheep small intestinal submucosa	1736:1778	Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.
33023379	11	11	theme	submucosa	1770:1778	arg1	biomaterial					1808:1818	an effective biomaterial	1795:1818	an effective biomaterial in diabetic wound healing	1795:1844	Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.
33023379	9	12	theme	significant	1297:1307	arg1	difference					1309:1318	no significant difference	1294:1318	no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05)	1294:1510	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	9	13	theme	reaction	1492:1499	arg1	terms					1387:1391	terms	1387:1391	terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05)	1387:1510	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	9	14	theme	experiment	1274:1283	arg1	results					1246:1252	histopathological results	1228:1252	histopathological results of a 12-day in vivo experiment	1228:1283	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	10	15	dep	transplanted	1549:1560	arg1	GS					1539:1540	GS	1539:1540	GS:HA:SIS	1539:1547	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	2	16	theme	amputations	288:298	arg1	reasons					258:264	the reasons	254:264	the reasons of non traumatic foot amputations	254:298	Diabetes comes first among the reasons of non traumatic foot amputations.
33023379	6	17	theme	hyaluronic	932:941	arg1	acid					943:946	hyaluronic acid	932:946	hyaluronic acid (GS:HA)	932:954	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	6	17	theme	hyaluronic	932:941	arg1	HA					952:953	GS:HA	949:953	GS:HA	949:953	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	4	18	theme	rat	627:629	arg1	model					631:635	a diabetic rat model	616:635	a diabetic rat model	616:635	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	5	19	theme	human	699:703	arg1	fibroblasts					705:715	human fibroblasts	699:715	human fibroblasts	699:715	The decellularized SIS membranes had no cytotoxic effects on human fibroblasts and supported capillary formation by HUVECs in a fibroblast-HUVEC co-culture.
33023379	9	20	theme	control	1330:1336	arg1	groups					1377:1382	the control, GS, GS:HA, and GS:HA:SIS transplanted groups	1326:1382	the control, GS, GS:HA, and GS:HA:SIS transplanted groups	1326:1382	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	4	21	theme	small	428:432	arg1	SIS					456:458	SIS	456:458	SIS	456:458	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	4	21	theme	small	428:432	arg1	submucosa					445:453	sheep small intestinal submucosa	422:453	sheep small intestinal submucosa (SIS)	422:459	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	7	22	dep	GS	1007:1008	arg1	underwent					1025:1033	underwent	1025:1033	underwent a 24.8 ± 5.4% weight loss in a 7-day in vitro erosion test	1025:1092	The GS:HA:SIS sponges underwent a 24.8 ± 5.4% weight loss in a 7-day in vitro erosion test.
33023379	11	23	theme	diabetic	1823:1830	arg1	healing					1838:1844	diabetic wound healing	1823:1844	diabetic wound healing	1823:1844	Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.
33023379	1	24	theme	technology	137:146	arg1	development					122:132	the fast development	113:132	the fast development of technology in the world	113:159	Despite the fast development of technology in the world, diabetic foot wounds cause deaths and massive economical losses.
33023379	11	25	theme	wound	1832:1836	arg1	healing					1838:1844	diabetic wound healing	1823:1844	diabetic wound healing	1823:1844	Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.
33023379	6	26	theme	hyaluronic	969:978	arg1	acid					980:983	hyaluronic acid	969:983	hyaluronic acid	969:983	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	11	27	from	biomaterial	1808:1818	arg1	healing					1838:1844	diabetic wound healing	1823:1844	diabetic wound healing	1823:1844	Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.
33023379	11	28	theme	Preclinical	1702:1712	arg1	studies					1714:1720	Preclinical studies	1702:1720	Preclinical studies	1702:1720	Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.
33023379	4	29	theme	based	461:465	arg1	sponges					481:487	sheep small intestinal submucosa (SIS) based biocompatible sponges	422:487	sheep small intestinal submucosa (SIS) based biocompatible sponges	422:487	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	5	30	theme	decellularized	642:655	arg1	membranes					661:669	The decellularized SIS membranes	638:669	The decellularized SIS membranes	638:669	The decellularized SIS membranes had no cytotoxic effects on human fibroblasts and supported capillary formation by HUVECs in a fibroblast-HUVEC co-culture.
33023379	3	31	theme	progressing	342:352	arg1	wounds					354:359	these fast progressing wounds	331:359	these fast progressing wounds	331:359	To reduce the healing time of these fast progressing wounds, effective wound dressings are in high demand.
33023379	0	32	theme	wounds	97:102	arg1	treatment					75:83	treatment	75:83	treatment of diabetic wounds	75:102	Composite sponges from sheep decellularized small intestinal submucosa for treatment of diabetic wounds.
33023379	6	33	dep	GS	991:992	arg1	HA					994:995	HA	994:995	GS:HA:SIS	991:999	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	6	33	dep	GS	991:992	arg1	SIS					997:999	SIS	997:999	GS:HA:SIS	991:999	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	5	34	theme	capillary	731:739	arg1	formation					741:749	capillary formation	731:749	capillary formation by HUVECs	731:759	The decellularized SIS membranes had no cytotoxic effects on human fibroblasts and supported capillary formation by HUVECs in a fibroblast-HUVEC co-culture.
33023379	3	35	theme	wound	372:376	arg1	dressings					378:386	effective wound dressings	362:386	effective wound dressings	362:386	To reduce the healing time of these fast progressing wounds, effective wound dressings are in high demand.
33023379	0	36	theme	Composite	0:8	arg1	sponges					10:16	Composite sponges	0:16	Composite sponges from sheep	0:27	Composite sponges from sheep decellularized small intestinal submucosa for treatment of diabetic wounds.
33023379	9	37	theme	transplanted	1364:1375	arg1	groups					1377:1382	the control, GS, GS:HA, and GS:HA:SIS transplanted groups	1326:1382	the control, GS, GS:HA, and GS:HA:SIS transplanted groups	1326:1382	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	7	38	theme	weight	1049:1054	arg1	loss					1056:1059	a 24.8 ± 5.4% weight loss	1035:1059	a 24.8 ± 5.4% weight loss	1035:1059	The GS:HA:SIS sponges underwent a 24.8 ± 5.4% weight loss in a 7-day in vitro erosion test.
33023379	3	39	theme	high	395:398	arg1	demand					400:405	high demand	395:405	high demand	395:405	To reduce the healing time of these fast progressing wounds, effective wound dressings are in high demand.
33023379	4	40	theme	wound	541:545	arg1	healing					547:553	their wound healing	535:553	their wound healing potential	535:563	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	10	41	theme	complete	1593:1600	arg1	regeneration					1612:1623	a complete epidermal regeneration	1591:1623	a complete epidermal regeneration	1591:1623	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	7	42	theme	24.8 ± 5.4	1037:1046	arg1	%					1047:1047	%	1047:1047	%	1047:1047	The GS:HA:SIS sponges underwent a 24.8 ± 5.4% weight loss in a 7-day in vitro erosion test.
33023379	5	43	theme	fibroblast-HUVEC	766:781	arg1	co-culture					783:792	a fibroblast-HUVEC co-culture	764:792	a fibroblast-HUVEC co-culture	764:792	The decellularized SIS membranes had no cytotoxic effects on human fibroblasts and supported capillary formation by HUVECs in a fibroblast-HUVEC co-culture.
33023379	5	44	contain	had	671:673	arg2	effects					688:694	no cytotoxic effects	675:694	no cytotoxic effects	675:694	The decellularized SIS membranes had no cytotoxic effects on human fibroblasts and supported capillary formation by HUVECs in a fibroblast-HUVEC co-culture.
33023379	5	44	contain	had	671:673	arg1	membranes					661:669	The decellularized SIS membranes	638:669	The decellularized SIS membranes	638:669	The decellularized SIS membranes had no cytotoxic effects on human fibroblasts and supported capillary formation by HUVECs in a fibroblast-HUVEC co-culture.
33023379	0	45	theme	intestinal	50:59	arg1	submucosa					61:69	small intestinal submucosa	44:69	small intestinal submucosa for treatment of diabetic wounds	44:102	Composite sponges from sheep decellularized small intestinal submucosa for treatment of diabetic wounds.
33023379	9	46	theme	Statistical	1204:1214	arg1	analyses					1216:1223	Statistical analyses	1204:1223	Statistical analyses of histopathological results of a 12-day in vivo experiment	1204:1283	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	0	47	from	sheep	23:27	arg1	sponges					10:16	Composite sponges	0:16	Composite sponges from sheep	0:27	Composite sponges from sheep decellularized small intestinal submucosa for treatment of diabetic wounds.
33023379	9	48	theme	tissue	1408:1413	arg1	thickness					1415:1423	granulation tissue thickness	1396:1423	granulation tissue thickness	1396:1423	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	9	49	from	difference	1309:1318	arg1	terms					1387:1391	terms	1387:1391	terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05)	1387:1510	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	10	50	contain	had	1587:1589	arg2	regeneration					1612:1623	a complete epidermal regeneration	1591:1623	a complete epidermal regeneration	1591:1623	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	10	50	contain	had	1587:1589	arg1	%					1570:1570	80%	1568:1570	80% of the animals	1568:1585	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	10	50	contain	had	1587:1589	arg1	animals					1579:1585	the animals	1575:1585	the animals	1575:1585	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	4	51	theme	SIS	509:511	arg1	decellularization					513:529	SIS decellularization	509:529	SIS decellularization	509:529	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	7	52	dep	in	1072:1073	arg1	vitro					1075:1079	vitro	1075:1079	vitro	1075:1079	The GS:HA:SIS sponges underwent a 24.8 ± 5.4% weight loss in a 7-day in vitro erosion test.
33023379	6	53	theme	different	839:847	arg1	compositions					849:860	three different compositions	833:860	three different compositions	833:860	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	4	54	theme	full	585:588	arg1	defects					605:611	full thickness skin defects	585:611	full thickness skin defects in a diabetic rat model	585:635	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	10	55	theme	other	1520:1524	arg1	hand					1526:1529	the other hand	1516:1529	the other hand	1516:1529	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	9	56	theme	results	1246:1252	arg1	analyses					1216:1223	Statistical analyses	1204:1223	Statistical analyses of histopathological results of a 12-day in vivo experiment	1204:1283	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	9	57	theme	deposition	1435:1444	arg1	terms					1387:1391	terms	1387:1391	terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05)	1387:1510	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	6	58	dep	prepared	867:874	arg1	gelatin					923:929	gelatin	923:929	gelatin	923:929	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	6	58	dep	prepared	867:874	arg1	gelatin					909:915	gelatin	909:915	gelatin (GS)	909:920	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	6	58	dep	prepared	867:874	arg1	GS					918:919	GS	918:919	GS	918:919	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	7	59	theme	erosion	1081:1087	arg1	test					1089:1092	a 7-day in vitro erosion test	1064:1092	a 7-day in vitro erosion test	1064:1092	The GS:HA:SIS sponges underwent a 24.8 ± 5.4% weight loss in a 7-day in vitro erosion test.
33023379	9	60	theme	capillary	1447:1455	arg1	formation					1464:1472	capillary vessel formation	1447:1472	capillary vessel formation	1447:1472	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	2	61	theme	foot	283:286	arg1	amputations					288:298	non traumatic foot amputations	269:298	non traumatic foot amputations	269:298	Diabetes comes first among the reasons of non traumatic foot amputations.
33023379	9	62	theme	in	1266:1267	arg1	experiment					1274:1283	a 12-day in vivo experiment	1257:1283	a 12-day in vivo experiment	1257:1283	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	9	63	theme	formation	1464:1472	arg1	terms					1387:1391	terms	1387:1391	terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05)	1387:1510	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	6	64	theme	Glutaraldehyde	795:808	arg1	sponges					822:828	Glutaraldehyde crosslinked sponges	795:828	Glutaraldehyde crosslinked sponges of three different compositions	795:860	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	2	65	theme	non	269:271	arg1	amputations					288:298	non traumatic foot amputations	269:298	non traumatic foot amputations	269:298	Diabetes comes first among the reasons of non traumatic foot amputations.
33023379	1	66	theme	diabetic	162:169	arg1	wounds					176:181	diabetic foot wounds	162:181	diabetic foot wounds	162:181	Despite the fast development of technology in the world, diabetic foot wounds cause deaths and massive economical losses.
33023379	6	67	theme	diabetic	889:896	arg1	model					902:906	a diabetic rat model	887:906	a diabetic rat model	887:906	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	10	68	theme	control	1671:1677	arg1	group					1679:1683	the control group	1667:1683	the control group (30%, P < 0.05)	1667:1699	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	11	69	theme	intestinal	1759:1768	arg1	submucosa					1770:1778	sheep small intestinal submucosa	1747:1778	sheep small intestinal submucosa	1747:1778	Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.
33023379	6	70	theme	GS	949:950	arg1	acid					943:946	hyaluronic acid	932:946	hyaluronic acid (GS:HA)	932:954	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	6	70	theme	GS	949:950	arg1	HA					952:953	GS:HA	949:953	GS:HA	949:953	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	8	71	contain	had	1107:1109	arg1	sponges					1099:1105	All sponges	1095:1105	All sponges	1095:1105	All sponges had a similar Young's modulus under compression but GS:HA:SIS had the highest (5.00 ± 0.04 kPa).
33023379	8	71	contain	had	1107:1109	arg2	modulus					1129:1135	a similar Young's modulus	1111:1135	a similar Young's modulus	1111:1135	All sponges had a similar Young's modulus under compression but GS:HA:SIS had the highest (5.00 ± 0.04 kPa).
33023379	5	72	theme	cytotoxic	678:686	arg1	effects					688:694	no cytotoxic effects	675:694	no cytotoxic effects	675:694	The decellularized SIS membranes had no cytotoxic effects on human fibroblasts and supported capillary formation by HUVECs in a fibroblast-HUVEC co-culture.
33023379	11	73	theme	sheep	1747:1751	arg1	submucosa					1770:1778	sheep small intestinal submucosa	1747:1778	sheep small intestinal submucosa	1747:1778	Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.
33023379	1	74	theme	deaths	189:194	arg1	losses					219:224	deaths and massive economical losses	189:224	deaths and massive economical losses	189:224	Despite the fast development of technology in the world, diabetic foot wounds cause deaths and massive economical losses.
33023379	8	75	contain	had	1169:1171	arg2	5.00 ± 0.04 kPa					1186:1200	5.00 ± 0.04 kPa	1186:1200	5.00 ± 0.04 kPa	1186:1200	All sponges had a similar Young's modulus under compression but GS:HA:SIS had the highest (5.00 ± 0.04 kPa).
33023379	8	75	contain	had	1169:1171	arg1	SIS					1165:1167	HA:SIS	1162:1167	HA:SIS	1162:1167	All sponges had a similar Young's modulus under compression but GS:HA:SIS had the highest (5.00 ± 0.04 kPa).
33023379	8	75	contain	had	1169:1171	arg2	highest					1177:1183	highest	1177:1183	highest	1177:1183	All sponges had a similar Young's modulus under compression but GS:HA:SIS had the highest (5.00 ± 0.04 kPa).
33023379	4	76	theme	sheep	422:426	arg1	SIS					456:458	SIS	456:458	SIS	456:458	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	4	76	theme	sheep	422:426	arg1	submucosa					445:453	sheep small intestinal submucosa	422:453	sheep small intestinal submucosa (SIS)	422:459	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	8	77	theme	Young	1121:1125	arg1	modulus					1129:1135	a similar Young's modulus	1111:1135	a similar Young's modulus	1111:1135	All sponges had a similar Young's modulus under compression but GS:HA:SIS had the highest (5.00 ± 0.04 kPa).
33023379	9	78	theme	body	1487:1490	arg1	P > 0.05					1502:1509	P > 0.05	1502:1509	P > 0.05	1502:1509	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	9	78	theme	body	1487:1490	arg1	reaction					1492:1499	foreign body reaction	1479:1499	foreign body reaction (P > 0.05)	1479:1510	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	1	79	theme	massive	200:206	arg1	losses					219:224	deaths and massive economical losses	189:224	deaths and massive economical losses	189:224	Despite the fast development of technology in the world, diabetic foot wounds cause deaths and massive economical losses.
33023379	11	80	used	used	1787:1790	arg2	biomaterial					1808:1818	an effective biomaterial	1795:1818	an effective biomaterial in diabetic wound healing	1795:1844	Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.
33023379	11	80	used	used	1787:1790	arg2	ECM					1740:1742	the ECM	1736:1742	the ECM of sheep small intestinal submucosa	1736:1778	Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.
33023379	4	81	theme	intestinal	434:443	arg1	SIS					456:458	SIS	456:458	SIS	456:458	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	4	81	theme	intestinal	434:443	arg1	submucosa					445:453	sheep small intestinal submucosa	422:453	sheep small intestinal submucosa (SIS)	422:459	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	4	82	theme	diabetic	618:625	arg1	model					631:635	a diabetic rat model	616:635	a diabetic rat model	616:635	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	5	83	theme	SIS	657:659	arg1	membranes					661:669	The decellularized SIS membranes	638:669	The decellularized SIS membranes	638:669	The decellularized SIS membranes had no cytotoxic effects on human fibroblasts and supported capillary formation by HUVECs in a fibroblast-HUVEC co-culture.
33023379	10	84	theme	transplanted	1549:1560	arg1	group					1562:1566	the GS:HA:SIS transplanted group	1535:1566	the GS:HA:SIS transplanted group	1535:1566	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	1	85	theme	fast	117:120	arg1	development					122:132	the fast development	113:132	the fast development of technology in the world	113:159	Despite the fast development of technology in the world, diabetic foot wounds cause deaths and massive economical losses.
33023379	9	86	dep	in	1266:1267	arg1	vivo					1269:1272	vivo	1269:1272	vivo	1269:1272	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	10	87	dep	GS	1539:1540	arg1	SIS					1545:1547	SIS	1545:1547	GS:HA:SIS	1539:1547	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	10	87	dep	GS	1539:1540	arg1	HA					1542:1543	HA	1542:1543	GS:HA:SIS	1539:1547	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	10	88	theme	animals	1579:1585	arg1	%					1570:1570	80%	1568:1570	80% of the animals	1568:1585	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	10	88	theme	animals	1579:1585	arg1	animals					1579:1585	the animals	1575:1585	the animals	1575:1585	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	11	89	theme	effective	1798:1806	arg1	ECM					1740:1742	the ECM	1736:1742	the ECM of sheep small intestinal submucosa	1736:1778	Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.
33023379	11	89	theme	effective	1798:1806	arg1	biomaterial					1808:1818	an effective biomaterial	1795:1818	an effective biomaterial in diabetic wound healing	1795:1844	Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.
33023379	4	90	from	defects	605:611	arg1	model					631:635	a diabetic rat model	616:635	a diabetic rat model	616:635	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	4	91	theme	biocompatible	467:479	arg1	sponges					481:487	sheep small intestinal submucosa (SIS) based biocompatible sponges	422:487	sheep small intestinal submucosa (SIS) based biocompatible sponges	422:487	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	8	92	theme	HA	1162:1163	arg1	SIS					1165:1167	HA:SIS	1162:1167	HA:SIS	1162:1167	All sponges had a similar Young's modulus under compression but GS:HA:SIS had the highest (5.00 ± 0.04 kPa).
33023379	0	93	theme	diabetic	88:95	arg1	wounds					97:102	diabetic wounds	88:102	diabetic wounds	88:102	Composite sponges from sheep decellularized small intestinal submucosa for treatment of diabetic wounds.
33023379	3	94	theme	healing	315:321	arg1	time					323:326	the healing time	311:326	the healing time of these fast progressing wounds	311:359	To reduce the healing time of these fast progressing wounds, effective wound dressings are in high demand.
33023379	7	95	theme	in	1072:1073	arg1	test					1089:1092	a 7-day in vitro erosion test	1064:1092	a 7-day in vitro erosion test	1064:1092	The GS:HA:SIS sponges underwent a 24.8 ± 5.4% weight loss in a 7-day in vitro erosion test.
33023379	11	96	theme	small	1753:1757	arg1	submucosa					1770:1778	sheep small intestinal submucosa	1747:1778	sheep small intestinal submucosa	1747:1778	Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.
33023379	3	97	theme	wounds	354:359	arg1	time					323:326	the healing time	311:326	the healing time of these fast progressing wounds	311:359	To reduce the healing time of these fast progressing wounds, effective wound dressings are in high demand.
33023379	3	98	theme	fast	337:340	arg1	wounds					354:359	these fast progressing wounds	331:359	these fast progressing wounds	331:359	To reduce the healing time of these fast progressing wounds, effective wound dressings are in high demand.
33023379	10	99	dep	group	1679:1683	arg1	P < 0.05					1691:1698	P < 0.05	1691:1698	P < 0.05	1691:1698	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	10	99	dep	group	1679:1683	arg1	%					1688:1688	30%	1686:1688	30%	1686:1688	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	7	100	theme	%	1047:1047	arg1	loss					1056:1059	a 24.8 ± 5.4% weight loss	1035:1059	a 24.8 ± 5.4% weight loss	1035:1059	The GS:HA:SIS sponges underwent a 24.8 ± 5.4% weight loss in a 7-day in vitro erosion test.
33023379	1	101	from	development	122:132	arg1	world					155:159	the world	151:159	the world	151:159	Despite the fast development of technology in the world, diabetic foot wounds cause deaths and massive economical losses.
33023379	3	102	theme	effective	362:370	arg1	dressings					378:386	effective wound dressings	362:386	effective wound dressings	362:386	To reduce the healing time of these fast progressing wounds, effective wound dressings are in high demand.
33023379	4	103	theme	healing	547:553	arg1	potential					555:563	their wound healing potential	535:563	their wound healing potential	535:563	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	10	104	theme	epidermal	1602:1610	arg1	regeneration					1612:1623	a complete epidermal regeneration	1591:1623	a complete epidermal regeneration	1591:1623	On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05).
33023379	0	105	theme	small	44:48	arg1	submucosa					61:69	small intestinal submucosa	44:69	small intestinal submucosa for treatment of diabetic wounds	44:102	Composite sponges from sheep decellularized small intestinal submucosa for treatment of diabetic wounds.
33023379	7	106	theme	7-day	1066:1070	arg1	test					1089:1092	a 7-day in vitro erosion test	1064:1092	a 7-day in vitro erosion test	1064:1092	The GS:HA:SIS sponges underwent a 24.8 ± 5.4% weight loss in a 7-day in vitro erosion test.
33023379	9	107	theme	granulation	1396:1406	arg1	thickness					1415:1423	granulation tissue thickness	1396:1423	granulation tissue thickness	1396:1423	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	4	108	dep	based	461:465	arg1	SIS					456:458	SIS	456:458	SIS	456:458	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	4	108	dep	based	461:465	arg1	submucosa					445:453	sheep small intestinal submucosa	422:453	sheep small intestinal submucosa (SIS)	422:459	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	6	109	theme	compositions	849:860	arg1	sponges					822:828	Glutaraldehyde crosslinked sponges	795:828	Glutaraldehyde crosslinked sponges of three different compositions	795:860	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	9	110	theme	thickness	1415:1423	arg1	terms					1387:1391	terms	1387:1391	terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05)	1387:1510	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	4	111	theme	thickness	590:598	arg1	defects					605:611	full thickness skin defects	585:611	full thickness skin defects in a diabetic rat model	585:635	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
33023379	9	112	dep	control	1330:1336	arg1	HA					1357:1358	HA	1357:1358	the control, GS, GS:HA, and GS:HA:SIS transplanted groups	1326:1382	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	9	112	dep	control	1330:1336	arg1	SIS					1360:1362	SIS	1360:1362	the control, GS, GS:HA, and GS:HA:SIS transplanted groups	1326:1382	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	9	113	theme	histopathological	1228:1244	arg1	results					1246:1252	histopathological results	1228:1252	histopathological results of a 12-day in vivo experiment	1228:1283	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	6	114	link	crosslinked	810:820	arg1	sponges					822:828	Glutaraldehyde crosslinked sponges	795:828	Glutaraldehyde crosslinked sponges of three different compositions	795:860	Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS).
33023379	1	115	theme	economical	208:217	arg1	losses					219:224	deaths and massive economical losses	189:224	deaths and massive economical losses	189:224	Despite the fast development of technology in the world, diabetic foot wounds cause deaths and massive economical losses.
33023379	9	116	theme	collagen	1426:1433	arg1	deposition					1435:1444	collagen deposition	1426:1444	collagen deposition	1426:1444	Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05).
33023379	4	117	theme	skin	600:603	arg1	defects					605:611	full thickness skin defects	585:611	full thickness skin defects in a diabetic rat model	585:635	In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model.
34885866	4	0	theme	mobile	500:505	arg1	modifiers					513:521	different mobile phase modifiers	490:521	different mobile phase modifiers (alcohols and acids)	490:542	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	4	1	theme	stationary	397:406	arg1	CSP					415:417	CSP	415:417	CSP	415:417	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	4	1	theme	stationary	397:406	arg1	phase					408:412	the chiral stationary phase	386:412	the chiral stationary phase (CSP) structure	386:428	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	5	2	theme	2.48	867:870	arg1	resolution					842:851	a resolution	840:851	a resolution (Rs) of about 2.48	840:870	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	5	2	theme	2.48	867:870	arg1	Rs					854:855	Rs	854:855	Rs	854:855	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	4	3	theme	different	490:498	arg1	modifiers					513:521	different mobile phase modifiers	490:521	different mobile phase modifiers (alcohols and acids)	490:542	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	4	4	theme	chiral	390:395	arg1	CSP					415:417	CSP	415:417	CSP	415:417	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	4	4	theme	chiral	390:395	arg1	phase					408:412	the chiral stationary phase	386:412	the chiral stationary phase (CSP) structure	386:428	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	4	5	theme	temperature	560:570	arg1	influences					372:381	The influences	368:381	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel	368:614	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	7	6	theme	molecular	1143:1151	arg1	research					1184:1191	molecular pharmacological and biological research	1143:1191	molecular pharmacological and biological research on closantel and its enantiomers	1143:1224	Thus, the proposed separation methods can facilitate molecular pharmacological and biological research on closantel and its enantiomers.
34885866	6	7	dep	Rs	969:970	arg1	3.79					979:982	3.79	979:982	3.79	979:982	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	4	8	dep	modifiers	513:521	arg1	acids					537:541	acids	537:541	acids	537:541	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	4	8	dep	modifiers	513:521	arg1	alcohols					524:531	alcohols	524:531	alcohols	524:531	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	4	9	theme	column	553:558	arg1	temperature					560:570	the column temperature	549:570	the column temperature	549:570	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	3	10	theme	high-performance	328:343	arg1	chromatography					352:365	normal-phase high-performance liquid chromatography	315:365	normal-phase high-performance liquid chromatography	315:365	In this work, two enantiomeric separation methods of closantel were explored by normal-phase high-performance liquid chromatography.
34885866	4	11	theme	phase	408:412	arg1	structure					420:428	the chiral stationary phase (CSP) structure	386:428	the chiral stationary phase (CSP) structure	386:428	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	5	12	dep	acid	794:797	arg1	v/v/v					810:814	v/v/v	810:814	v/v/v	810:814	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	5	12	dep	acid	794:797	arg1	97:3:0.1					800:807	97:3:0.1	800:807	97:3:0.1	800:807	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	6	13	theme	acid	1040:1043	arg1	phase					1083:1087	mobile phase	1076:1087	mobile phase	1076:1087	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	6	13	theme	acid	1040:1043	arg1	mixture					992:998	a mixture	990:998	a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v)	990:1062	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	3	14	theme	liquid	345:350	arg1	chromatography					352:365	normal-phase high-performance liquid chromatography	315:365	normal-phase high-performance liquid chromatography	315:365	In this work, two enantiomeric separation methods of closantel were explored by normal-phase high-performance liquid chromatography.
34885866	1	15	theme	antiparasitic	72:84	arg1	Closantel					56:64	Closantel	56:64	Closantel	56:64	Closantel is an antiparasitic drug marketed in a racemic form with one chiral center.
34885866	1	15	theme	antiparasitic	72:84	arg1	drug					86:89	an antiparasitic drug	69:89	an antiparasitic drug marketed in a racemic form with one chiral center	69:139	Closantel is an antiparasitic drug marketed in a racemic form with one chiral center.
34885866	5	16	theme	isopropyl	713:721	arg1	derivatives					723:733	isopropyl derivatives	713:733	isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v)	713:815	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	7	17	theme	proposed	1100:1107	arg1	methods					1120:1126	the proposed separation methods	1096:1126	the proposed separation methods	1096:1126	Thus, the proposed separation methods can facilitate molecular pharmacological and biological research on closantel and its enantiomers.
34885866	7	18	from	research	1184:1191	arg1	closantel					1196:1204	closantel	1196:1204	closantel	1196:1204	Thus, the proposed separation methods can facilitate molecular pharmacological and biological research on closantel and its enantiomers.
34885866	7	18	from	research	1184:1191	arg1	enantiomers					1214:1224	its enantiomers	1210:1224	its enantiomers	1210:1224	Thus, the proposed separation methods can facilitate molecular pharmacological and biological research on closantel and its enantiomers.
34885866	0	19	theme	Analytical	0:9	arg1	Separation					11:20	Analytical Separation	0:20	Analytical Separation of Closantel Enantiomers by HPLC	0:53	Analytical Separation of Closantel Enantiomers by HPLC.
34885866	6	20	theme	tris-carbamates	928:942	arg1	CSP					921:923	the CSP	917:923	the CSP of tris-carbamates of amylose with a higher Rs (about 3.79)	917:983	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	1	21	with	form	113:116	arg1	center					134:139	one chiral center	123:139	one chiral center	123:139	Closantel is an antiparasitic drug marketed in a racemic form with one chiral center.
34885866	0	22	theme	Closantel	25:33	arg1	Enantiomers					35:45	Closantel Enantiomers	25:45	Closantel Enantiomers	25:45	Analytical Separation of Closantel Enantiomers by HPLC.
34885866	5	23	with	phase	829:833	arg1	resolution					842:851	a resolution	840:851	a resolution (Rs) of about 2.48	840:870	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	5	23	with	phase	829:833	arg1	Rs					854:855	Rs	854:855	Rs	854:855	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	4	24	from	influences	372:381	arg1	separation					592:601	the enantiomeric separation	575:601	the enantiomeric separation of closantel	575:614	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	4	25	theme	closantel	606:614	arg1	separation					592:601	the enantiomeric separation	575:601	the enantiomeric separation of closantel	575:614	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	3	26	theme	enantiomeric	253:264	arg1	methods					277:283	two enantiomeric separation methods	249:283	two enantiomeric separation methods of closantel	249:296	In this work, two enantiomeric separation methods of closantel were explored by normal-phase high-performance liquid chromatography.
34885866	4	27	theme	mobile	435:440	arg1	composition					448:458	the mobile phase composition	431:458	the mobile phase composition	431:458	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	6	28	theme	mobile	1076:1081	arg1	phase					1083:1087	mobile phase	1076:1087	mobile phase	1076:1087	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	6	28	theme	mobile	1076:1081	arg1	mixture					992:998	a mixture	990:998	a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v)	990:1062	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	5	29	theme	mobile	822:827	arg1	phase					829:833	a mobile phase	820:833	a mobile phase with a resolution (Rs) of about 2.48	820:870	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	5	29	theme	mobile	822:827	arg1	enantiomers					653:663	The two enantiomers	645:663	The two enantiomers	645:663	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	5	30	theme	n-hexane-isopropanol-trifluoroacetic	757:792	arg1	acid					794:797	n-hexane-isopropanol-trifluoroacetic acid	757:797	n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v)	757:815	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	7	31	theme	separation	1109:1118	arg1	methods					1120:1126	the proposed separation methods	1096:1126	the proposed separation methods	1096:1126	Thus, the proposed separation methods can facilitate molecular pharmacological and biological research on closantel and its enantiomers.
34885866	2	32	theme	closantel	212:220	arg1	enantiomers					222:232	the closantel enantiomers	208:232	the closantel enantiomers	208:232	It is meaningful to develop a method for separating and analyzing the closantel enantiomers.
34885866	0	33	theme	Enantiomers	35:45	arg1	Separation					11:20	Analytical Separation	0:20	Analytical Separation of Closantel Enantiomers by HPLC	0:53	Analytical Separation of Closantel Enantiomers by HPLC.
34885866	4	34	theme	modifiers	513:521	arg1	structure					420:428	the chiral stationary phase (CSP) structure	386:428	the chiral stationary phase (CSP) structure	386:428	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	4	34	theme	modifiers	513:521	arg1	nature					465:470	the nature	461:470	the nature	461:470	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	4	34	theme	modifiers	513:521	arg1	temperature					560:570	the column temperature	549:570	the column temperature	549:570	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	4	34	theme	modifiers	513:521	arg1	proportion					476:485	proportion	476:485	proportion	476:485	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	4	34	theme	modifiers	513:521	arg1	composition					448:458	the mobile phase composition	431:458	the mobile phase composition	431:458	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	5	35	theme	acid	794:797	arg1	derivatives					723:733	isopropyl derivatives	713:733	isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v)	713:815	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	4	36	theme	composition	448:458	arg1	influences					372:381	The influences	368:381	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel	368:614	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	5	37	theme	derivatives	723:733	arg1	CSP					706:708	the novel CSP	696:708	the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v)	696:815	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	4	38	theme	phase	507:511	arg1	modifiers					513:521	different mobile phase modifiers	490:521	different mobile phase modifiers (alcohols and acids)	490:542	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	4	39	theme	phase	442:446	arg1	composition					448:458	the mobile phase composition	431:458	the mobile phase composition	431:458	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	1	40	theme	racemic	105:111	arg1	form					113:116	a racemic form	103:116	a racemic form with one chiral center	103:139	Closantel is an antiparasitic drug marketed in a racemic form with one chiral center.
34885866	5	41	theme	novel	700:704	arg1	CSP					706:708	the novel CSP	696:708	the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v)	696:815	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	3	42	theme	closantel	288:296	arg1	methods					277:283	two enantiomeric separation methods	249:283	two enantiomeric separation methods of closantel	249:296	In this work, two enantiomeric separation methods of closantel were explored by normal-phase high-performance liquid chromatography.
34885866	3	43	theme	separation	266:275	arg1	methods					277:283	two enantiomeric separation methods	249:283	two enantiomeric separation methods of closantel	249:296	In this work, two enantiomeric separation methods of closantel were explored by normal-phase high-performance liquid chromatography.
34885866	6	44	with	amylose	947:953	arg1	Rs					969:970	a higher Rs	960:970	a higher Rs (about 3.79)	960:983	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	5	45	theme	cyclofructan	738:749	arg1	derivatives					723:733	isopropyl derivatives	713:733	isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v)	713:815	The two enantiomers were successfully separated on the novel CSP of isopropyl derivatives of cyclofructan 6 and n-hexane-isopropanol-trifluoroacetic acid (97:3:0.1, v/v/v) as a mobile phase with a resolution (Rs) of about 2.48.
34885866	6	46	dep	acid	1040:1043	arg1	v/v/v					1057:1061	v/v/v	1057:1061	v/v/v	1057:1061	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	6	46	dep	acid	1040:1043	arg1	55:45:0.1					1046:1054	55:45:0.1	1046:1054	55:45:0.1	1046:1054	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	6	47	theme	amylose	947:953	arg1	tris-carbamates					928:942	tris-carbamates	928:942	tris-carbamates of amylose with a higher Rs (about 3.79)	928:983	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	7	48	dep	molecular	1143:1151	arg1	pharmacological					1153:1167	pharmacological	1153:1167	pharmacological	1153:1167	Thus, the proposed separation methods can facilitate molecular pharmacological and biological research on closantel and its enantiomers.
34885866	7	49	theme	biological	1173:1182	arg1	research					1184:1191	molecular pharmacological and biological research	1143:1191	molecular pharmacological and biological research on closantel and its enantiomers	1143:1224	Thus, the proposed separation methods can facilitate molecular pharmacological and biological research on closantel and its enantiomers.
34885866	4	50	theme	structure	420:428	arg1	influences					372:381	The influences	368:381	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel	368:614	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
34885866	1	51	theme	chiral	127:132	arg1	center					134:139	one chiral center	123:139	one chiral center	123:139	Closantel is an antiparasitic drug marketed in a racemic form with one chiral center.
34885866	6	52	theme	n-hexane-isopropanol-trifluoroacetic	1003:1038	arg1	acid					1040:1043	n-hexane-isopropanol-trifluoroacetic acid	1003:1043	n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v)	1003:1062	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	3	53	theme	normal-phase	315:326	arg1	chromatography					352:365	normal-phase high-performance liquid chromatography	315:365	normal-phase high-performance liquid chromatography	315:365	In this work, two enantiomeric separation methods of closantel were explored by normal-phase high-performance liquid chromatography.
34885866	6	54	theme	higher	962:967	arg1	Rs					969:970	a higher Rs	960:970	a higher Rs (about 3.79)	960:983	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	6	55	used	used	1068:1071	arg2	mixture					992:998	a mixture	990:998	a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v)	990:1062	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	6	55	used	used	1068:1071	arg2	phase					1083:1087	mobile phase	1076:1087	mobile phase	1076:1087	The enantiomers were also well separated on the CSP of tris-carbamates of amylose with a higher Rs (about 3.79) when a mixture of n-hexane-isopropanol-trifluoroacetic acid (55:45:0.1, v/v/v) was used as mobile phase.
34885866	4	56	theme	enantiomeric	579:590	arg1	separation					592:601	the enantiomeric separation	575:601	the enantiomeric separation of closantel	575:614	The influences of the chiral stationary phase (CSP) structure, the mobile phase composition, the nature and proportion of different mobile phase modifiers (alcohols and acids), and the column temperature on the enantiomeric separation of closantel were investigated in detail.
32485561	3	0	theme	microorganisms	787:800	arg1	evolution					743:751	the evolution	739:751	the evolution of the technological and spoilage microorganisms	739:800	No significant differences in aw were observed among the studied casing types for NMNF and MF fuets and for the evolution of the technological and spoilage microorganisms.
32485561	1	1	theme	dry-fermented	360:372	arg1	fuet					384:387	fuet	384:387	fuet	384:387	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	1	theme	dry-fermented	360:372	arg1	sausages					374:381	dry-fermented sausages	360:381	dry-fermented sausages (fuet) with no inoculation of moulds	360:418	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	2	theme	co-extruded	154:164	arg1	coatings					175:182	co-extruded alginate coatings	154:182	co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA)	154:278	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	3	3	theme	technological	760:772	arg1	microorganisms					787:800	the technological and spoilage microorganisms	756:800	microorganisms	787:800	No significant differences in aw were observed among the studied casing types for NMNF and MF fuets and for the evolution of the technological and spoilage microorganisms.
32485561	1	4	theme	fatty	242:246	arg1	acids					248:252	fatty acids	242:252	fatty acids	242:252	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	0	5	theme	sausages	94:101	arg1	production					66:75	the production	62:75	the production of dry-fermented sausages	62:101	Co-extruded alginate as an alternative to collagen casings in the production of dry-fermented sausages: Impact of coating composition.
32485561	1	6	theme	sausages	374:381	arg1	manufacturing					343:355	the manufacturing	339:355	the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds	339:418	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	6	7	theme	technological	1070:1082	arg1	point					1095:1099	a technological and safety point	1068:1099	point	1095:1099	Therefore, alginate coatings would be a feasible alternative to collagen casing from a technological and safety point of view.
32485561	2	8	dep	resulted	556:563	arg1	compared					599:606	compared	599:606	compared with alginate coating	599:628	Stuffing into collagen casings resulted in slower sausage drying kinetics compared with alginate coating.
32485561	1	9	theme	acids	248:252	arg1	protein					267:273	pea protein	263:273	pea protein (PA)	263:278	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	9	theme	acids	248:252	arg1	PA					276:277	PA	276:277	PA	276:277	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	9	theme	acids	248:252	arg1	EA					255:256	EA	255:256	EA	255:256	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	9	theme	acids	248:252	arg1	esters					232:237	polyglycerol esters	219:237	polyglycerol esters of fatty acids (EA)	219:257	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	9	theme	acids	248:252	arg1	additives					204:212	no extra additives	195:212	no extra additives (A)	195:216	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	9	theme	acids	248:252	arg1	A					215:215	A	215:215	A	215:215	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	0	10	theme	dry-fermented	80:92	arg1	sausages					94:101	dry-fermented sausages	80:101	dry-fermented sausages	80:101	Co-extruded alginate as an alternative to collagen casings in the production of dry-fermented sausages: Impact of coating composition.
32485561	3	11	theme	significant	634:644	arg1	differences					646:656	No significant differences	631:656	No significant differences in aw	631:662	No significant differences in aw were observed among the studied casing types for NMNF and MF fuets and for the evolution of the technological and spoilage microorganisms.
32485561	1	12	theme	moulds	413:418	arg1	inoculation					398:408	no inoculation	395:408	no inoculation of moulds	395:418	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	3	13	theme	studied	688:694	arg1	types					703:707	the studied casing types	684:707	the studied casing types	684:707	No significant differences in aw were observed among the studied casing types for NMNF and MF fuets and for the evolution of the technological and spoilage microorganisms.
32485561	1	14	dep	fermented	509:517	arg1	MF					520:521	MF	520:521	MF	520:521	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	15	theme	alginate	166:173	arg1	coatings					175:182	co-extruded alginate coatings	154:182	co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA)	154:278	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	2	16	theme	slower	568:573	arg1	kinetics					590:597	slower sausage drying kinetics	568:597	slower sausage drying kinetics	568:597	Stuffing into collagen casings resulted in slower sausage drying kinetics compared with alginate coating.
32485561	1	17	theme	coatings	175:182	arg1	performance					139:149	The performance	135:149	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA)	135:278	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	17	theme	coatings	175:182	arg1	alternative					299:309	an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF)	296:522	an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF)	296:522	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	18	theme	collagen	314:321	arg1	C					332:332	C	332:332	C	332:332	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	18	theme	collagen	314:321	arg1	casings					323:329	collagen casings	314:329	collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF)	314:522	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	2	19	theme	drying	583:588	arg1	kinetics					590:597	slower sausage drying kinetics	568:597	slower sausage drying kinetics	568:597	Stuffing into collagen casings resulted in slower sausage drying kinetics compared with alginate coating.
32485561	0	20	theme	Co-extruded	0:10	arg1	alginate					12:19	Co-extruded alginate	0:19	Co-extruded alginate as an alternative to collagen	0:49	Co-extruded alginate as an alternative to collagen casings in the production of dry-fermented sausages: Impact of coating composition.
32485561	2	21	theme	sausage	575:581	arg1	kinetics					590:597	slower sausage drying kinetics	568:597	slower sausage drying kinetics	568:597	Stuffing into collagen casings resulted in slower sausage drying kinetics compared with alginate coating.
32485561	0	22	theme	coating	114:120	arg1	composition					122:132	coating composition	114:132	coating composition	114:132	Co-extruded alginate as an alternative to collagen casings in the production of dry-fermented sausages: Impact of coating composition.
32485561	2	23	theme	collagen	539:546	arg1	casings					548:554	collagen casings	539:554	collagen casings	539:554	Stuffing into collagen casings resulted in slower sausage drying kinetics compared with alginate coating.
32485561	5	24	from	differences	913:923	arg1	properties					936:945	sensory properties	928:945	sensory properties	928:945	No significant differences on sensory properties between casing types were observed.
32485561	1	25	theme	extra	198:202	arg1	additives					204:212	no extra additives	195:212	no extra additives (A)	195:216	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	25	theme	extra	198:202	arg1	A					215:215	A	215:215	A	215:215	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	3	26	from	differences	646:656	arg1	aw					661:662	aw	661:662	aw	661:662	No significant differences in aw were observed among the studied casing types for NMNF and MF fuets and for the evolution of the technological and spoilage microorganisms.
32485561	5	27	theme	casing	955:960	arg1	types					962:966	casing types	955:966	casing types	955:966	No significant differences on sensory properties between casing types were observed.
32485561	6	28	theme	feasible	1023:1030	arg1	alternative					1032:1042	a feasible alternative	1021:1042	a feasible alternative to collagen casing from a technological and safety point of view	1021:1107	Therefore, alginate coatings would be a feasible alternative to collagen casing from a technological and safety point of view.
32485561	6	28	theme	feasible	1023:1030	arg1	coatings					1003:1010	alginate coatings	994:1010	alginate coatings	994:1010	Therefore, alginate coatings would be a feasible alternative to collagen casing from a technological and safety point of view.
32485561	1	29	contain	containing	184:193	arg2	A					215:215	A	215:215	A	215:215	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	29	contain	containing	184:193	arg2	EA					255:256	EA	255:256	EA	255:256	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	29	contain	containing	184:193	arg2	protein					267:273	pea protein	263:273	pea protein (PA)	263:278	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	29	contain	containing	184:193	arg2	PA					276:277	PA	276:277	PA	276:277	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	29	contain	containing	184:193	arg2	additives					204:212	no extra additives	195:212	no extra additives (A)	195:216	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	29	contain	containing	184:193	arg2	esters					232:237	polyglycerol esters	219:237	polyglycerol esters of fatty acids (EA)	219:257	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	29	contain	containing	184:193	arg1	coatings					175:182	co-extruded alginate coatings	154:182	co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA)	154:278	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	30	theme	pea	263:265	arg1	protein					267:273	pea protein	263:273	pea protein (PA)	263:278	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	30	theme	pea	263:265	arg1	PA					276:277	PA	276:277	PA	276:277	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	0	31	theme	composition	122:132	arg1	Impact					104:109	Impact	104:109	Impact of coating composition	104:132	Co-extruded alginate as an alternative to collagen casings in the production of dry-fermented sausages: Impact of coating composition.
32485561	3	32	theme	casing	696:701	arg1	types					703:707	the studied casing types	684:707	the studied casing types	684:707	No significant differences in aw were observed among the studied casing types for NMNF and MF fuets and for the evolution of the technological and spoilage microorganisms.
32485561	4	33	theme	pH	848:849	arg1	values					851:856	lower pH values	842:856	lower pH values	842:856	Fuets coated with A, EA, and PA showed lower pH values than fuets stuffed in collagen casings.
32485561	5	34	theme	significant	901:911	arg1	differences					913:923	No significant differences	898:923	No significant differences on sensory properties between casing types	898:966	No significant differences on sensory properties between casing types were observed.
32485561	2	35	theme	alginate	613:620	arg1	coating					622:628	alginate coating	613:628	alginate coating	613:628	Stuffing into collagen casings resulted in slower sausage drying kinetics compared with alginate coating.
32485561	4	36	theme	collagen	880:887	arg1	casings					889:895	collagen casings	880:895	collagen casings	880:895	Fuets coated with A, EA, and PA showed lower pH values than fuets stuffed in collagen casings.
32485561	6	37	theme	view	1104:1107	arg1	point					1095:1099	a technological and safety point	1068:1099	point	1095:1099	Therefore, alginate coatings would be a feasible alternative to collagen casing from a technological and safety point of view.
32485561	4	38	theme	lower	842:846	arg1	values					851:856	lower pH values	842:856	lower pH values	842:856	Fuets coated with A, EA, and PA showed lower pH values than fuets stuffed in collagen casings.
32485561	1	39	with	sausages	374:381	arg1	inoculation					398:408	no inoculation	395:408	no inoculation of moulds	395:418	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	5	40	theme	sensory	928:934	arg1	properties					936:945	sensory properties	928:945	sensory properties	928:945	No significant differences on sensory properties between casing types were observed.
32485561	3	41	theme	NMNF	713:716	arg1	fuets					725:729	NMNF and MF fuets	713:729	NMNF and MF fuets	713:729	No significant differences in aw were observed among the studied casing types for NMNF and MF fuets and for the evolution of the technological and spoilage microorganisms.
32485561	6	42	theme	safety	1088:1093	arg1	point					1095:1099	a technological and safety point	1068:1099	point	1095:1099	Therefore, alginate coatings would be a feasible alternative to collagen casing from a technological and safety point of view.
32485561	1	43	theme	fermentation	434:445	arg1	NMNF					453:456	NMNF	453:456	NMNF	453:456	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	43	theme	fermentation	434:445	arg1	step					447:450	a fermentation step	432:450	a fermentation step (NMNF)	432:457	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	6	44	theme	alginate	994:1001	arg1	alternative					1032:1042	a feasible alternative	1021:1042	a feasible alternative to collagen casing from a technological and safety point of view	1021:1107	Therefore, alginate coatings would be a feasible alternative to collagen casing from a technological and safety point of view.
32485561	6	44	theme	alginate	994:1001	arg1	coatings					1003:1010	alginate coatings	994:1010	alginate coatings	994:1010	Therefore, alginate coatings would be a feasible alternative to collagen casing from a technological and safety point of view.
32485561	1	45	theme	polyglycerol	219:230	arg1	EA					255:256	EA	255:256	EA	255:256	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	1	45	theme	polyglycerol	219:230	arg1	esters					232:237	polyglycerol esters	219:237	polyglycerol esters of fatty acids (EA)	219:257	The performance of co-extruded alginate coatings containing no extra additives (A), polyglycerol esters of fatty acids (EA), or pea protein (PA) was assessed as an alternative to collagen casings (C) for the manufacturing of dry-fermented sausages (fuet) with no inoculation of moulds and without a fermentation step (NMNF) and fuet inoculated with Penicillium candidum and fermented (MF).
32485561	3	46	theme	MF	722:723	arg1	fuets					725:729	NMNF and MF fuets	713:729	NMNF and MF fuets	713:729	No significant differences in aw were observed among the studied casing types for NMNF and MF fuets and for the evolution of the technological and spoilage microorganisms.
32485561	3	47	theme	spoilage	778:785	arg1	microorganisms					787:800	the technological and spoilage microorganisms	756:800	microorganisms	787:800	No significant differences in aw were observed among the studied casing types for NMNF and MF fuets and for the evolution of the technological and spoilage microorganisms.
33857698	2	0	theme	chitosan	341:348	arg1	CS					361:362	CS	361:362	CS	361:362	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	2	0	theme	chitosan	341:348	arg1	substrate					350:358	a chitosan substrate	339:358	a chitosan substrate (CS)	339:363	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	6	1	theme	potential	939:947	arg1	candidate					949:957	a potential candidate	937:957	a potential candidate for a new type of clinically applicable antibiotics	937:1009	Moreover, compared to traditional antibiotics, the as prepared nanocomposites in the present work do not likely cause bacterial drug resistance, which make them a potential candidate for a new type of clinically applicable antibiotics.
33857698	6	2	theme	present	861:867	arg1	work					869:872	the present work	857:872	the present work	857:872	Moreover, compared to traditional antibiotics, the as prepared nanocomposites in the present work do not likely cause bacterial drug resistance, which make them a potential candidate for a new type of clinically applicable antibiotics.
33857698	3	3	theme	in-situation	369:380	arg1	growth					382:387	An in-situation growth	366:387	An in-situation growth of nanocomposites	366:405	An in-situation growth of nanocomposites was adopted to study their antibacterial properties.
33857698	2	4	theme	CQDs	308:311	arg1	nanoparticles					322:334	prepared CQDs and Ag2S nanoparticles	299:334	prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS)	299:363	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	2	4	theme	CQDs	308:311	arg1	CQDs/Ag2S/CS					258:269	A nano composite CQDs/Ag2S/CS	241:269	A nano composite CQDs/Ag2S/CS	241:269	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	5	5	theme	common	697:702	arg1	bacteria					715:722	common pathogenic bacteria	697:722	common pathogenic bacteria	697:722	The CQDs/Ag2S/CS nanocomposites exhibited excellent inhibition not only against common pathogenic bacteria, but also those well-known drug-resistant bacteria.
33857698	2	6	from	nanoparticles	322:334	arg1	CS					361:362	CS	361:362	CS	361:362	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	2	6	from	nanoparticles	322:334	arg1	substrate					350:358	a chitosan substrate	339:358	a chitosan substrate (CS)	339:363	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	1	7	theme	Aldol	163:167	arg1	reaction					184:191	Aldol polymerization reaction	163:191	Aldol polymerization reaction	163:191	The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source.
33857698	6	8	theme	prepared	830:837	arg1	nanocomposites					839:852	the as prepared nanocomposites	823:852	the as prepared nanocomposites in the present work	823:872	Moreover, compared to traditional antibiotics, the as prepared nanocomposites in the present work do not likely cause bacterial drug resistance, which make them a potential candidate for a new type of clinically applicable antibiotics.
33857698	1	9	theme	polymerization	169:182	arg1	reaction					184:191	Aldol polymerization reaction	163:191	Aldol polymerization reaction	163:191	The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source.
33857698	0	10	theme	quantum	7:13	arg1	dots					15:18	Carbon quantum dots	0:18	Carbon quantum dots	0:18	Carbon quantum dots modified Ag2S/CS nanocomposite as effective antibacterial agents.
33857698	5	11	theme	excellent	659:667	arg1	inhibition					669:678	excellent inhibition	659:678	excellent inhibition	659:678	The CQDs/Ag2S/CS nanocomposites exhibited excellent inhibition not only against common pathogenic bacteria, but also those well-known drug-resistant bacteria.
33857698	1	12	theme	present	90:96	arg1	study					98:102	The present study	86:102	The present study	86:102	The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source.
33857698	0	13	theme	Carbon	0:5	arg1	dots					15:18	Carbon quantum dots	0:18	Carbon quantum dots	0:18	Carbon quantum dots modified Ag2S/CS nanocomposite as effective antibacterial agents.
33857698	2	14	theme	prepared	299:306	arg1	nanoparticles					322:334	prepared CQDs and Ag2S nanoparticles	299:334	prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS)	299:363	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	2	14	theme	prepared	299:306	arg1	CQDs/Ag2S/CS					258:269	A nano composite CQDs/Ag2S/CS	241:269	A nano composite CQDs/Ag2S/CS	241:269	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	6	15	theme	antibiotics	999:1009	arg1	type					969:972	a new type	963:972	a new type of clinically applicable antibiotics	963:1009	Moreover, compared to traditional antibiotics, the as prepared nanocomposites in the present work do not likely cause bacterial drug resistance, which make them a potential candidate for a new type of clinically applicable antibiotics.
33857698	5	16	theme	CQDs/Ag2S/CS	621:632	arg1	nanocomposites					634:647	The CQDs/Ag2S/CS nanocomposites	617:647	The CQDs/Ag2S/CS nanocomposites	617:647	The CQDs/Ag2S/CS nanocomposites exhibited excellent inhibition not only against common pathogenic bacteria, but also those well-known drug-resistant bacteria.
33857698	1	17	theme	wherein	194:200	arg1	acetone					202:208	wherein acetone	194:208	wherein acetone	194:208	The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source.
33857698	1	17	theme	wherein	194:200	arg1	source					233:238	the carbon source	222:238	the carbon source	222:238	The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source.
33857698	6	18	theme	applicable	988:997	arg1	antibiotics					999:1009	clinically applicable antibiotics	977:1009	clinically applicable antibiotics	977:1009	Moreover, compared to traditional antibiotics, the as prepared nanocomposites in the present work do not likely cause bacterial drug resistance, which make them a potential candidate for a new type of clinically applicable antibiotics.
33857698	5	19	theme	well-known	740:749	arg1	bacteria					766:773	those well-known drug-resistant bacteria	734:773	those well-known drug-resistant bacteria	734:773	The CQDs/Ag2S/CS nanocomposites exhibited excellent inhibition not only against common pathogenic bacteria, but also those well-known drug-resistant bacteria.
33857698	6	20	theme	drug	904:907	arg1	resistance					909:918	bacterial drug resistance	894:918	bacterial drug resistance	894:918	Moreover, compared to traditional antibiotics, the as prepared nanocomposites in the present work do not likely cause bacterial drug resistance, which make them a potential candidate for a new type of clinically applicable antibiotics.
33857698	1	21	used	used	214:217	arg2	acetone					202:208	wherein acetone	194:208	wherein acetone	194:208	The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source.
33857698	1	21	used	used	214:217	arg2	source					233:238	the carbon source	222:238	the carbon source	222:238	The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source.
33857698	0	22	theme	Ag2S/CS	29:35	arg1	nanocomposite					37:49	Ag2S/CS nanocomposite	29:49	Ag2S/CS nanocomposite	29:49	Carbon quantum dots modified Ag2S/CS nanocomposite as effective antibacterial agents.
33857698	0	22	theme	Ag2S/CS	29:35	arg1	agents					78:83	effective antibacterial agents	54:83	effective antibacterial agents	54:83	Carbon quantum dots modified Ag2S/CS nanocomposite as effective antibacterial agents.
33857698	4	23	dep	coli	511:514	arg1	Gram-negative					517:529	Gram-negative	517:529	Gram-negative	517:529	Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative) and methicillin-resistant Staphylococcus aureus were selected as the model bacteria.
33857698	3	24	theme	nanocomposites	392:405	arg1	growth					382:387	An in-situation growth	366:387	An in-situation growth of nanocomposites	366:405	An in-situation growth of nanocomposites was adopted to study their antibacterial properties.
33857698	6	25	theme	bacterial	894:902	arg1	resistance					909:918	bacterial drug resistance	894:918	bacterial drug resistance	894:918	Moreover, compared to traditional antibiotics, the as prepared nanocomposites in the present work do not likely cause bacterial drug resistance, which make them a potential candidate for a new type of clinically applicable antibiotics.
33857698	3	26	theme	antibacterial	434:446	arg1	properties					448:457	their antibacterial properties	428:457	their antibacterial properties	428:457	An in-situation growth of nanocomposites was adopted to study their antibacterial properties.
33857698	0	27	theme	effective	54:62	arg1	nanocomposite					37:49	Ag2S/CS nanocomposite	29:49	Ag2S/CS nanocomposite	29:49	Carbon quantum dots modified Ag2S/CS nanocomposite as effective antibacterial agents.
33857698	0	27	theme	effective	54:62	arg1	agents					78:83	effective antibacterial agents	54:83	effective antibacterial agents	54:83	Carbon quantum dots modified Ag2S/CS nanocomposite as effective antibacterial agents.
33857698	5	28	theme	pathogenic	704:713	arg1	bacteria					715:722	common pathogenic bacteria	697:722	common pathogenic bacteria	697:722	The CQDs/Ag2S/CS nanocomposites exhibited excellent inhibition not only against common pathogenic bacteria, but also those well-known drug-resistant bacteria.
33857698	6	29	theme	traditional	798:808	arg1	antibiotics					810:820	traditional antibiotics	798:820	traditional antibiotics	798:820	Moreover, compared to traditional antibiotics, the as prepared nanocomposites in the present work do not likely cause bacterial drug resistance, which make them a potential candidate for a new type of clinically applicable antibiotics.
33857698	5	30	theme	drug-resistant	751:764	arg1	bacteria					766:773	those well-known drug-resistant bacteria	734:773	those well-known drug-resistant bacteria	734:773	The CQDs/Ag2S/CS nanocomposites exhibited excellent inhibition not only against common pathogenic bacteria, but also those well-known drug-resistant bacteria.
33857698	6	31	theme	new	965:967	arg1	type					969:972	a new type	963:972	a new type of clinically applicable antibiotics	963:1009	Moreover, compared to traditional antibiotics, the as prepared nanocomposites in the present work do not likely cause bacterial drug resistance, which make them a potential candidate for a new type of clinically applicable antibiotics.
33857698	4	32	theme	model	601:605	arg1	aureus					573:578	Staphylococcus aureus	558:578	methicillin-resistant Staphylococcus aureus	536:578	Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative) and methicillin-resistant Staphylococcus aureus were selected as the model bacteria.
33857698	4	32	theme	model	601:605	arg1	aureus					475:480	Staphylococcus aureus	460:480	Staphylococcus aureus (Gram-positive)	460:496	Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative) and methicillin-resistant Staphylococcus aureus were selected as the model bacteria.
33857698	4	32	theme	model	601:605	arg1	bacteria					607:614	the model bacteria	597:614	the model bacteria	597:614	Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative) and methicillin-resistant Staphylococcus aureus were selected as the model bacteria.
33857698	4	32	theme	model	601:605	arg1	coli					511:514	Escherichia coli	499:514	Escherichia coli (Gram-negative)	499:530	Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative) and methicillin-resistant Staphylococcus aureus were selected as the model bacteria.
33857698	1	33	theme	carbon	128:133	arg1	CQDs					149:152	CQDs	149:152	CQDs	149:152	The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source.
33857698	1	33	theme	carbon	128:133	arg1	dots					143:146	carbon quantum dots	128:146	carbon quantum dots (CQDs)	128:153	The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source.
33857698	2	34	theme	composite	248:256	arg1	nanoparticles					322:334	prepared CQDs and Ag2S nanoparticles	299:334	prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS)	299:363	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	2	34	theme	composite	248:256	arg1	CQDs/Ag2S/CS					258:269	A nano composite CQDs/Ag2S/CS	241:269	A nano composite CQDs/Ag2S/CS	241:269	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	1	35	theme	quantum	135:141	arg1	CQDs					149:152	CQDs	149:152	CQDs	149:152	The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source.
33857698	1	35	theme	quantum	135:141	arg1	dots					143:146	carbon quantum dots	128:146	carbon quantum dots (CQDs)	128:153	The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source.
33857698	2	36	theme	nano	243:246	arg1	nanoparticles					322:334	prepared CQDs and Ag2S nanoparticles	299:334	prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS)	299:363	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	2	36	theme	nano	243:246	arg1	CQDs/Ag2S/CS					258:269	A nano composite CQDs/Ag2S/CS	241:269	A nano composite CQDs/Ag2S/CS	241:269	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	2	37	theme	Ag2S	317:320	arg1	nanoparticles					322:334	prepared CQDs and Ag2S nanoparticles	299:334	prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS)	299:363	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	2	37	theme	Ag2S	317:320	arg1	CQDs/Ag2S/CS					258:269	A nano composite CQDs/Ag2S/CS	241:269	A nano composite CQDs/Ag2S/CS	241:269	A nano composite CQDs/Ag2S/CS was developed by loading as prepared CQDs and Ag2S nanoparticles on a chitosan substrate (CS).
33857698	6	38	from	nanocomposites	839:852	arg1	work					869:872	the present work	857:872	the present work	857:872	Moreover, compared to traditional antibiotics, the as prepared nanocomposites in the present work do not likely cause bacterial drug resistance, which make them a potential candidate for a new type of clinically applicable antibiotics.
33857698	1	39	theme	carbon	226:231	arg1	acetone					202:208	wherein acetone	194:208	wherein acetone	194:208	The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source.
33857698	1	39	theme	carbon	226:231	arg1	source					233:238	the carbon source	222:238	the carbon source	222:238	The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source.
33857698	0	40	theme	antibacterial	64:76	arg1	nanocomposite					37:49	Ag2S/CS nanocomposite	29:49	Ag2S/CS nanocomposite	29:49	Carbon quantum dots modified Ag2S/CS nanocomposite as effective antibacterial agents.
33857698	0	40	theme	antibacterial	64:76	arg1	agents					78:83	effective antibacterial agents	54:83	effective antibacterial agents	54:83	Carbon quantum dots modified Ag2S/CS nanocomposite as effective antibacterial agents.
34952341	0	0	theme	pulsed	86:91	arg1	ultrasound					93:102	sweep frequency pulsed ultrasound	70:102	sweep frequency pulsed ultrasound technology	70:113	Preparation of tuna skin collagen-chitosan composite film improved by sweep frequency pulsed ultrasound technology.
34952341	3	1	from	increases	613:621	arg1	%					653:653	27.14%	648:653	27.14%	648:653	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	1	from	increases	613:621	arg1	%					754:754	12.15%	749:754	12.15%	749:754	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	1	from	increases	613:621	arg1	%					686:686	16.54%	681:686	16.54%	681:686	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	1	from	increases	613:621	arg1	strength					638:645	the tensile strength	626:645	the tensile strength (27.14%)	626:654	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	1	from	increases	613:621	arg1	elongation					660:669	elongation	660:669	elongation at break (16.54%)	660:687	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	1	from	increases	613:621	arg1	permeability					735:746	the water vapor permeability	719:746	the water vapor permeability (12.15%)	719:755	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	1	from	increases	613:621	arg1	break					674:678	break	674:678	break	674:678	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	1	2	from	collagen	172:179	arg1	film					152:155	a natural food packaging film	127:155	a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS)	127:204	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	3	3	theme	vapor	729:733	arg1	%					754:754	12.15%	749:754	12.15%	749:754	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	3	theme	vapor	729:733	arg1	permeability					735:746	the water vapor permeability	719:746	the water vapor permeability (12.15%)	719:755	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	0	4	theme	frequency	76:84	arg1	ultrasound					93:102	sweep frequency pulsed ultrasound	70:102	sweep frequency pulsed ultrasound technology	70:113	Preparation of tuna skin collagen-chitosan composite film improved by sweep frequency pulsed ultrasound technology.
34952341	3	5	from	break	674:678	arg1	decrease					707:714	a significant decrease	693:714	a significant decrease in the water vapor permeability (12.15%)	693:755	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	5	from	break	674:678	arg1	%					653:653	27.14%	648:653	27.14%	648:653	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	5	from	break	674:678	arg1	%					686:686	16.54%	681:686	16.54%	681:686	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	5	from	break	674:678	arg1	strength					638:645	the tensile strength	626:645	the tensile strength (27.14%)	626:654	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	5	from	break	674:678	arg1	elongation					660:669	elongation	660:669	elongation at break (16.54%)	660:687	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	5	from	break	674:678	arg1	increases					613:621	Significant increases	601:621	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%)	601:687	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	2	6	theme	10 min	593:598	arg1	ratio					556:560	pulse duty ratio	545:560	pulse duty ratio of 77%	545:567	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	6	theme	10 min	593:598	arg1	density					492:498	power density	486:498	power density of 100 W/L	486:509	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	6	theme	10 min	593:598	arg1	time					585:588	ultrasonic time	574:588	ultrasonic time of 10 min	574:598	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	6	theme	10 min	593:598	arg1	cycle					528:532	sweep frequency cycle	512:532	sweep frequency cycle of 100 ms	512:542	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	6	theme	10 min	593:598	arg1	conditions					412:421	The optimum preparation conditions	388:421	The optimum preparation conditions of the SFPU-TSC-CTS film	388:446	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	6	theme	10 min	593:598	arg1	frequency					459:467	sweep frequency	453:467	sweep frequency of 28 ± 0.5 kHz	453:483	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	1	7	theme	tuna	162:165	arg1	TSC					182:184	TSC	182:184	TSC	182:184	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	1	7	theme	tuna	162:165	arg1	collagen					172:179	tuna skin collagen	162:179	tuna skin collagen (TSC)	162:185	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	6	8	theme	antibacterial	1309:1321	arg1	activities					1323:1332	good antioxidant and antibacterial activities	1288:1332	good antioxidant and antibacterial activities	1288:1332	Moreover, SFPU-TSC-CTS film also presented good antioxidant and antibacterial activities.
34952341	1	9	theme	mechanical	222:231	arg1	properties					253:262	its mechanical and physicochemical properties	218:262	its mechanical and physicochemical properties	218:262	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	4	10	theme	moderate	794:801	arg1	treatment					808:816	a moderate SFPU treatment	792:816	a moderate SFPU treatment	792:816	Thus, a moderate SFPU treatment can significantly improve the moisture resistance and mechanical properties of the film.
34952341	3	11	theme	tensile	630:636	arg1	strength					638:645	the tensile strength	626:645	the tensile strength (27.14%)	626:654	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	11	theme	tensile	630:636	arg1	%					653:653	27.14%	648:653	27.14%	648:653	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	2	12	theme	duty	551:554	arg1	ratio					556:560	pulse duty ratio	545:560	pulse duty ratio of 77%	545:567	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	4	13	theme	mechanical	872:881	arg1	properties					883:892	mechanical properties	872:892	mechanical properties	872:892	Thus, a moderate SFPU treatment can significantly improve the moisture resistance and mechanical properties of the film.
34952341	0	14	theme	ultrasound	93:102	arg1	technology					104:113	sweep frequency pulsed ultrasound technology	70:113	sweep frequency pulsed ultrasound technology	70:113	Preparation of tuna skin collagen-chitosan composite film improved by sweep frequency pulsed ultrasound technology.
34952341	2	15	theme	pulse	545:549	arg1	ratio					556:560	pulse duty ratio	545:560	pulse duty ratio of 77%	545:567	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	4	16	theme	SFPU	803:806	arg1	treatment					808:816	a moderate SFPU treatment	792:816	a moderate SFPU treatment	792:816	Thus, a moderate SFPU treatment can significantly improve the moisture resistance and mechanical properties of the film.
34952341	7	17	theme	film	1433:1436	arg1	quality					1407:1413	the quality	1403:1413	the quality of food packaging film	1403:1436	Therefore, SFPU was an effective auxiliary technology for improving the quality of food packaging film and can be deeply explored.
34952341	1	18	theme	physicochemical	237:251	arg1	properties					253:262	its mechanical and physicochemical properties	218:262	its mechanical and physicochemical properties	218:262	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	2	19	theme	power	486:490	arg1	density					492:498	power density	486:498	power density of 100 W/L	486:509	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	5	20	theme	good	983:986	arg1	crystallinity					988:1000	a good crystallinity	981:1000	a good crystallinity	981:1000	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	2	21	theme	ultrasonic	574:583	arg1	time					585:588	ultrasonic time	574:588	ultrasonic time of 10 min	574:598	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	5	22	theme	X-ray	1189:1193	arg1	XRD					1208:1210	XRD	1208:1210	XRD	1208:1210	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	5	22	theme	X-ray	1189:1193	arg1	diffraction					1195:1205	X-ray diffraction	1189:1205	X-ray diffraction (XRD)	1189:1211	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	1	23	theme	skin	167:170	arg1	TSC					182:184	TSC	182:184	TSC	182:184	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	1	23	theme	skin	167:170	arg1	collagen					172:179	tuna skin collagen	162:179	tuna skin collagen (TSC)	162:185	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	3	24	theme	water	723:727	arg1	%					754:754	12.15%	749:754	12.15%	749:754	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	24	theme	water	723:727	arg1	permeability					735:746	the water vapor permeability	719:746	the water vapor permeability (12.15%)	719:755	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	1	25	theme	new	330:332	arg1	ultrasound					292:301	the sweep frequency pulsed ultrasound	265:301	the sweep frequency pulsed ultrasound (SFPU)	265:308	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	1	25	theme	new	330:332	arg1	technology					334:343	a new technology	328:343	a new technology	328:343	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	5	26	theme	higher	1008:1013	arg1	thermostability					1015:1029	a higher thermostability	1006:1029	a higher thermostability	1006:1029	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	7	27	theme	packaging	1423:1431	arg1	film					1433:1436	food packaging film	1418:1436	food packaging film	1418:1436	Therefore, SFPU was an effective auxiliary technology for improving the quality of food packaging film and can be deeply explored.
34952341	4	28	theme	moisture	848:855	arg1	resistance					857:866	moisture resistance	848:866	moisture resistance	848:866	Thus, a moderate SFPU treatment can significantly improve the moisture resistance and mechanical properties of the film.
34952341	2	29	theme	film	443:446	arg1	conditions					412:421	The optimum preparation conditions	388:421	The optimum preparation conditions of the SFPU-TSC-CTS film	388:446	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	29	theme	film	443:446	arg1	frequency					459:467	sweep frequency	453:467	sweep frequency of 28 ± 0.5 kHz	453:483	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	30	theme	sweep	453:457	arg1	conditions					412:421	The optimum preparation conditions	388:421	The optimum preparation conditions of the SFPU-TSC-CTS film	388:446	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	30	theme	sweep	453:457	arg1	frequency					459:467	sweep frequency	453:467	sweep frequency of 28 ± 0.5 kHz	453:483	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	31	theme	%	567:567	arg1	ratio					556:560	pulse duty ratio	545:560	pulse duty ratio of 77%	545:567	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	31	theme	%	567:567	arg1	density					492:498	power density	486:498	power density of 100 W/L	486:509	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	31	theme	%	567:567	arg1	time					585:588	ultrasonic time	574:588	ultrasonic time of 10 min	574:598	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	31	theme	%	567:567	arg1	cycle					528:532	sweep frequency cycle	512:532	sweep frequency cycle of 100 ms	512:542	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	31	theme	%	567:567	arg1	conditions					412:421	The optimum preparation conditions	388:421	The optimum preparation conditions of the SFPU-TSC-CTS film	388:446	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	31	theme	%	567:567	arg1	frequency					459:467	sweep frequency	453:467	sweep frequency of 28 ± 0.5 kHz	453:483	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	32	theme	28 ± 0.5 kHz	472:483	arg1	ratio					556:560	pulse duty ratio	545:560	pulse duty ratio of 77%	545:567	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	32	theme	28 ± 0.5 kHz	472:483	arg1	density					492:498	power density	486:498	power density of 100 W/L	486:509	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	32	theme	28 ± 0.5 kHz	472:483	arg1	time					585:588	ultrasonic time	574:588	ultrasonic time of 10 min	574:598	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	32	theme	28 ± 0.5 kHz	472:483	arg1	cycle					528:532	sweep frequency cycle	512:532	sweep frequency cycle of 100 ms	512:542	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	32	theme	28 ± 0.5 kHz	472:483	arg1	conditions					412:421	The optimum preparation conditions	388:421	The optimum preparation conditions of the SFPU-TSC-CTS film	388:446	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	32	theme	28 ± 0.5 kHz	472:483	arg1	frequency					459:467	sweep frequency	453:467	sweep frequency of 28 ± 0.5 kHz	453:483	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	6	33	theme	good	1288:1291	arg1	activities					1323:1332	good antioxidant and antibacterial activities	1288:1332	good antioxidant and antibacterial activities	1288:1332	Moreover, SFPU-TSC-CTS film also presented good antioxidant and antibacterial activities.
34952341	5	34	theme	ordered	950:956	arg1	structure					970:978	a more ordered and compact structure	943:978	a more ordered and compact structure	943:978	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	7	35	theme	auxiliary	1368:1376	arg1	technology					1378:1387	an effective auxiliary technology	1355:1387	an effective auxiliary technology for improving the quality of food packaging film and can be deeply explored	1355:1463	Therefore, SFPU was an effective auxiliary technology for improving the quality of food packaging film and can be deeply explored.
34952341	7	35	theme	auxiliary	1368:1376	arg1	SFPU					1346:1349	SFPU	1346:1349	SFPU	1346:1349	Therefore, SFPU was an effective auxiliary technology for improving the quality of food packaging film and can be deeply explored.
34952341	0	36	theme	skin	20:23	arg1	film					53:56	tuna skin collagen-chitosan composite film	15:56	tuna skin collagen-chitosan composite film	15:56	Preparation of tuna skin collagen-chitosan composite film improved by sweep frequency pulsed ultrasound technology.
34952341	2	37	theme	frequency	518:526	arg1	cycle					528:532	sweep frequency cycle	512:532	sweep frequency cycle of 100 ms	512:542	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	0	38	theme	tuna	15:18	arg1	film					53:56	tuna skin collagen-chitosan composite film	15:56	tuna skin collagen-chitosan composite film	15:56	Preparation of tuna skin collagen-chitosan composite film improved by sweep frequency pulsed ultrasound technology.
34952341	4	39	theme	film	901:904	arg1	resistance					857:866	moisture resistance	848:866	moisture resistance	848:866	Thus, a moderate SFPU treatment can significantly improve the moisture resistance and mechanical properties of the film.
34952341	4	39	theme	film	901:904	arg1	properties					883:892	mechanical properties	872:892	mechanical properties	872:892	Thus, a moderate SFPU treatment can significantly improve the moisture resistance and mechanical properties of the film.
34952341	2	40	theme	sweep	512:516	arg1	cycle					528:532	sweep frequency cycle	512:532	sweep frequency cycle of 100 ms	512:542	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	6	41	theme	SFPU-TSC-CTS	1255:1266	arg1	film					1268:1271	SFPU-TSC-CTS film	1255:1271	SFPU-TSC-CTS film	1255:1271	Moreover, SFPU-TSC-CTS film also presented good antioxidant and antibacterial activities.
34952341	0	42	theme	composite	43:51	arg1	film					53:56	tuna skin collagen-chitosan composite film	15:56	tuna skin collagen-chitosan composite film	15:56	Preparation of tuna skin collagen-chitosan composite film improved by sweep frequency pulsed ultrasound technology.
34952341	1	43	theme	sweep	269:273	arg1	SFPU					304:307	SFPU	304:307	SFPU	304:307	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	1	43	theme	sweep	269:273	arg1	ultrasound					292:301	the sweep frequency pulsed ultrasound	265:301	the sweep frequency pulsed ultrasound (SFPU)	265:308	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	1	43	theme	sweep	269:273	arg1	technology					334:343	a new technology	328:343	a new technology	328:343	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	5	44	theme	compact	962:968	arg1	structure					970:978	a more ordered and compact structure	943:978	a more ordered and compact structure	943:978	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	0	45	theme	collagen-chitosan	25:41	arg1	film					53:56	tuna skin collagen-chitosan composite film	15:56	tuna skin collagen-chitosan composite film	15:56	Preparation of tuna skin collagen-chitosan composite film improved by sweep frequency pulsed ultrasound technology.
34952341	1	46	theme	frequency	275:283	arg1	SFPU					304:307	SFPU	304:307	SFPU	304:307	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	1	46	theme	frequency	275:283	arg1	ultrasound					292:301	the sweep frequency pulsed ultrasound	265:301	the sweep frequency pulsed ultrasound (SFPU)	265:308	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	1	46	theme	frequency	275:283	arg1	technology					334:343	a new technology	328:343	a new technology	328:343	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	2	47	theme	100 W/L	503:509	arg1	ratio					556:560	pulse duty ratio	545:560	pulse duty ratio of 77%	545:567	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	47	theme	100 W/L	503:509	arg1	density					492:498	power density	486:498	power density of 100 W/L	486:509	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	47	theme	100 W/L	503:509	arg1	time					585:588	ultrasonic time	574:588	ultrasonic time of 10 min	574:598	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	47	theme	100 W/L	503:509	arg1	cycle					528:532	sweep frequency cycle	512:532	sweep frequency cycle of 100 ms	512:542	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	47	theme	100 W/L	503:509	arg1	conditions					412:421	The optimum preparation conditions	388:421	The optimum preparation conditions of the SFPU-TSC-CTS film	388:446	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	47	theme	100 W/L	503:509	arg1	frequency					459:467	sweep frequency	453:467	sweep frequency of 28 ± 0.5 kHz	453:483	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	48	theme	preparation	400:410	arg1	conditions					412:421	The optimum preparation conditions	388:421	The optimum preparation conditions of the SFPU-TSC-CTS film	388:446	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	48	theme	preparation	400:410	arg1	frequency					459:467	sweep frequency	453:467	sweep frequency of 28 ± 0.5 kHz	453:483	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	1	49	from	chitosan	191:198	arg1	film					152:155	a natural food packaging film	127:155	a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS)	127:204	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	7	50	theme	effective	1358:1366	arg1	technology					1378:1387	an effective auxiliary technology	1355:1387	an effective auxiliary technology for improving the quality of food packaging film and can be deeply explored	1355:1463	Therefore, SFPU was an effective auxiliary technology for improving the quality of food packaging film and can be deeply explored.
34952341	7	50	theme	effective	1358:1366	arg1	SFPU					1346:1349	SFPU	1346:1349	SFPU	1346:1349	Therefore, SFPU was an effective auxiliary technology for improving the quality of food packaging film and can be deeply explored.
34952341	2	51	theme	SFPU-TSC-CTS	430:441	arg1	film					443:446	the SFPU-TSC-CTS film	426:446	the SFPU-TSC-CTS film	426:446	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	1	52	theme	pulsed	285:290	arg1	SFPU					304:307	SFPU	304:307	SFPU	304:307	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	1	52	theme	pulsed	285:290	arg1	ultrasound					292:301	the sweep frequency pulsed ultrasound	265:301	the sweep frequency pulsed ultrasound (SFPU)	265:308	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	1	52	theme	pulsed	285:290	arg1	technology					334:343	a new technology	328:343	a new technology	328:343	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	5	53	theme	stability	1226:1234	arg1	indexes					1236:1242	thermal stability indexes	1218:1242	thermal stability indexes	1218:1242	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	0	54	theme	film	53:56	arg1	Preparation					0:10	Preparation	0:10	Preparation of tuna skin collagen-chitosan composite film	0:56	Preparation of tuna skin collagen-chitosan composite film improved by sweep frequency pulsed ultrasound technology.
34952341	2	55	theme	100 ms	537:542	arg1	ratio					556:560	pulse duty ratio	545:560	pulse duty ratio of 77%	545:567	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	55	theme	100 ms	537:542	arg1	density					492:498	power density	486:498	power density of 100 W/L	486:509	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	55	theme	100 ms	537:542	arg1	time					585:588	ultrasonic time	574:588	ultrasonic time of 10 min	574:598	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	55	theme	100 ms	537:542	arg1	cycle					528:532	sweep frequency cycle	512:532	sweep frequency cycle of 100 ms	512:542	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	55	theme	100 ms	537:542	arg1	conditions					412:421	The optimum preparation conditions	388:421	The optimum preparation conditions of the SFPU-TSC-CTS film	388:446	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	55	theme	100 ms	537:542	arg1	frequency					459:467	sweep frequency	453:467	sweep frequency of 28 ± 0.5 kHz	453:483	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	1	56	theme	conventional	367:378	arg1	method					380:385	the conventional method	363:385	the conventional method	363:385	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	5	57	theme	SFPU-TSC-CTS	1034:1045	arg1	film					1047:1050	SFPU-TSC-CTS film	1034:1050	SFPU-TSC-CTS film	1034:1050	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	3	58	from	decrease	707:714	arg1	%					653:653	27.14%	648:653	27.14%	648:653	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	58	from	decrease	707:714	arg1	%					754:754	12.15%	749:754	12.15%	749:754	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	58	from	decrease	707:714	arg1	%					686:686	16.54%	681:686	16.54%	681:686	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	58	from	decrease	707:714	arg1	strength					638:645	the tensile strength	626:645	the tensile strength (27.14%)	626:654	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	58	from	decrease	707:714	arg1	elongation					660:669	elongation	660:669	elongation at break (16.54%)	660:687	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	58	from	decrease	707:714	arg1	permeability					735:746	the water vapor permeability	719:746	the water vapor permeability (12.15%)	719:755	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	3	58	from	decrease	707:714	arg1	break					674:678	break	674:678	break	674:678	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	1	59	theme	natural	129:135	arg1	film					152:155	a natural food packaging film	127:155	a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS)	127:204	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	4	60	dep	resistance	857:866	arg1	the					844:846	the	844:846	the	844:846	Thus, a moderate SFPU treatment can significantly improve the moisture resistance and mechanical properties of the film.
34952341	5	61	dep	Fourier	1080:1086	arg1	transform					1088:1096	transform	1088:1096	transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes	1088:1242	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	5	62	theme	thermal	1218:1224	arg1	indexes					1236:1242	thermal stability indexes	1218:1242	thermal stability indexes	1218:1242	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	1	63	theme	food	137:140	arg1	film					152:155	a natural food packaging film	127:155	a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS)	127:204	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	5	64	theme	scanning	1153:1160	arg1	SEM					1183:1185	SEM	1183:1185	SEM	1183:1185	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	5	64	theme	scanning	1153:1160	arg1	microscopy					1171:1180	scanning electron microscopy	1153:1180	scanning electron microscopy (SEM)	1153:1186	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	0	65	theme	sweep	70:74	arg1	ultrasound					93:102	sweep frequency pulsed ultrasound	70:102	sweep frequency pulsed ultrasound technology	70:113	Preparation of tuna skin collagen-chitosan composite film improved by sweep frequency pulsed ultrasound technology.
34952341	3	66	theme	Significant	601:611	arg1	increases					613:621	Significant increases	601:621	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%)	601:687	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34952341	7	67	theme	food	1418:1421	arg1	film					1433:1436	food packaging film	1418:1436	food packaging film	1418:1436	Therefore, SFPU was an effective auxiliary technology for improving the quality of food packaging film and can be deeply explored.
34952341	1	68	theme	packaging	142:150	arg1	film					152:155	a natural food packaging film	127:155	a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS)	127:204	To produce a natural food packaging film from tuna skin collagen (TSC) and chitosan (CTS) and improve its mechanical and physicochemical properties, the sweep frequency pulsed ultrasound (SFPU) was introduced as a new technology and compared with the conventional method.
34952341	5	69	theme	electron	1162:1169	arg1	SEM					1183:1185	SEM	1183:1185	SEM	1183:1185	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	5	69	theme	electron	1162:1169	arg1	microscopy					1171:1180	scanning electron microscopy	1153:1180	scanning electron microscopy (SEM)	1153:1186	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	5	70	theme	infrared	1098:1105	arg1	FTIR					1121:1124	FTIR	1121:1124	FTIR	1121:1124	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	5	70	theme	infrared	1098:1105	arg1	spectroscopy					1107:1118	infrared spectroscopy	1098:1118	infrared spectroscopy (FTIR)	1098:1125	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	5	71	theme	film	1047:1050	arg1	crystallinity					988:1000	a good crystallinity	981:1000	a good crystallinity	981:1000	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	5	71	theme	film	1047:1050	arg1	thermostability					1015:1029	a higher thermostability	1006:1029	a higher thermostability	1006:1029	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	5	71	theme	film	1047:1050	arg1	structure					970:978	a more ordered and compact structure	943:978	a more ordered and compact structure	943:978	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	2	72	theme	optimum	392:398	arg1	conditions					412:421	The optimum preparation conditions	388:421	The optimum preparation conditions of the SFPU-TSC-CTS film	388:446	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	2	72	theme	optimum	392:398	arg1	frequency					459:467	sweep frequency	453:467	sweep frequency of 28 ± 0.5 kHz	453:483	The optimum preparation conditions of the SFPU-TSC-CTS film were sweep frequency of 28 ± 0.5 kHz, power density of 100 W/L, sweep frequency cycle of 100 ms, pulse duty ratio of 77%, and ultrasonic time of 10 min.
34952341	6	73	theme	antioxidant	1293:1303	arg1	activities					1323:1332	good antioxidant and antibacterial activities	1288:1332	good antioxidant and antibacterial activities	1288:1332	Moreover, SFPU-TSC-CTS film also presented good antioxidant and antibacterial activities.
34952341	5	74	theme	circular	1128:1135	arg1	CD					1148:1149	CD	1148:1149	CD	1148:1149	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	5	74	theme	circular	1128:1135	arg1	dichroism					1137:1145	circular dichroism	1128:1145	circular dichroism (CD)	1128:1150	These enhancements were achieved by a more ordered and compact structure, a good crystallinity and a higher thermostability of SFPU-TSC-CTS film, which were verified by the Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), scanning electron microscopy (SEM), X-ray diffraction (XRD), and thermal stability indexes.
34952341	3	75	theme	significant	695:705	arg1	decrease					707:714	a significant decrease	693:714	a significant decrease in the water vapor permeability (12.15%)	693:755	Significant increases in the tensile strength (27.14%) and elongation at break (16.54%) and a significant decrease in the water vapor permeability (12.15%) were observed by sonication.
34492463	3	0	theme	batch	674:678	arg1	mode					680:683	batch mode	674:683	batch mode	674:683	The adsorption capacity of Fe-MCG towards SSA via batch mode reaches up to 135 mg/g at 293 K.
34492463	2	1	theme	composite	551:559	arg1	formation					534:542	the successful formation	519:542	the successful formation of the composite with enhanced microstructure and superparamagnetic properties	519:621	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	9	2	theme	experimental	1396:1407	arg1	results					1409:1415	the experimental results	1392:1415	the experimental results	1392:1415	Based on the experimental results and XPS analysis, the underlying mechanisms for the uptake of SSA onto Fe-MCG involve electrostatic forces, complexation, π-π stacking, and hydrogen bonding.
34492463	7	3	theme	NaOH	1250:1253	arg1	solution					1255:1262	0.01 mol/L NaOH solution	1239:1262	0.01 mol/L NaOH solution	1239:1262	The efficacy and reusability of the spent Fe-MCG was studied using 0.01 mol/L NaOH solution.
34492463	9	4	theme	XPS	1421:1423	arg1	analysis					1425:1432	XPS analysis	1421:1432	XPS analysis	1421:1432	Based on the experimental results and XPS analysis, the underlying mechanisms for the uptake of SSA onto Fe-MCG involve electrostatic forces, complexation, π-π stacking, and hydrogen bonding.
34492463	2	5	theme	vibrating-sample	433:448	arg1	VSM					464:466	VSM	464:466	VSM	464:466	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	5	theme	vibrating-sample	433:448	arg1	magnetometry					450:461	vibrating-sample magnetometry	433:461	vibrating-sample magnetometry (VSM)	433:467	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	1	6	theme	aqueous	290:296	arg1	solution					298:305	aqueous solution	290:305	aqueous solution	290:305	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	4	7	theme	adsorption	817:826	arg1	processes					828:836	the chemical and physical adsorption processes	791:836	the chemical and physical adsorption processes both playing active roles	791:862	The adsorption of SSA onto Fe-MCG is driven by monolayer adsorption with the chemical and physical adsorption processes both playing active roles.
34492463	0	8	dep	oxide	109:113	arg1	removal					11:17	Adsorptive removal	0:17	Adsorptive removal of sulfosalicylic acid from aqueous medium by iron(III)	0:73	Adsorptive removal of sulfosalicylic acid from aqueous medium by iron(III)-loaded magnetic chitosan/graphene oxide.
34492463	10	9	theme	environmental	1687:1699	arg1	media					1701:1705	environmental media	1687:1705	environmental media	1687:1705	Overall, the excellent features of Fe-MCG enhance its potential as an adsorbent for the sequestration of SSA in environmental media.
34492463	0	10	theme	-loaded	74:80	arg1	oxide					109:113	-loaded magnetic chitosan/graphene oxide	74:113	-loaded magnetic chitosan/graphene oxide	74:113	Adsorptive removal of sulfosalicylic acid from aqueous medium by iron(III)-loaded magnetic chitosan/graphene oxide.
34492463	7	11	theme	Fe-MCG	1214:1219	arg1	efficacy					1176:1183	efficacy	1176:1183	efficacy	1176:1183	The efficacy and reusability of the spent Fe-MCG was studied using 0.01 mol/L NaOH solution.
34492463	7	11	theme	Fe-MCG	1214:1219	arg1	reusability					1189:1199	reusability	1189:1199	reusability	1189:1199	The efficacy and reusability of the spent Fe-MCG was studied using 0.01 mol/L NaOH solution.
34492463	0	12	from	medium	55:60	arg1	removal					11:17	Adsorptive removal	0:17	Adsorptive removal of sulfosalicylic acid from aqueous medium by iron(III)	0:73	Adsorptive removal of sulfosalicylic acid from aqueous medium by iron(III)-loaded magnetic chitosan/graphene oxide.
34492463	1	13	from	acid	276:279	arg1	solution					298:305	aqueous solution	290:305	aqueous solution	290:305	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	8	14	theme	SSA	1307:1309	arg1	desorption					1293:1302	the desorption	1289:1302	the desorption of SSA from Fe-MCG	1289:1321	The kinetic process for the desorption of SSA from Fe-MCG is well described by the pseudo-second-order kinetic model.
34492463	0	15	theme	chitosan/graphene	91:107	arg1	oxide					109:113	-loaded magnetic chitosan/graphene oxide	74:113	-loaded magnetic chitosan/graphene oxide	74:113	Adsorptive removal of sulfosalicylic acid from aqueous medium by iron(III)-loaded magnetic chitosan/graphene oxide.
34492463	1	16	from	removal	250:256	arg1	solution					298:305	aqueous solution	290:305	aqueous solution	290:305	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	2	17	theme	techniques	378:387	arg1	application					338:348	the application	334:348	the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS)	334:511	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	4	18	theme	SSA	736:738	arg1	adsorption					722:731	The adsorption	718:731	The adsorption of SSA onto Fe-MCG	718:750	The adsorption of SSA onto Fe-MCG is driven by monolayer adsorption with the chemical and physical adsorption processes both playing active roles.
34492463	9	19	theme	underlying	1439:1448	arg1	mechanisms					1450:1459	the underlying mechanisms	1435:1459	the underlying mechanisms for the uptake of SSA onto Fe-MCG	1435:1493	Based on the experimental results and XPS analysis, the underlying mechanisms for the uptake of SSA onto Fe-MCG involve electrostatic forces, complexation, π-π stacking, and hydrogen bonding.
34492463	0	20	theme	magnetic	82:89	arg1	oxide					109:113	-loaded magnetic chitosan/graphene oxide	74:113	-loaded magnetic chitosan/graphene oxide	74:113	Adsorptive removal of sulfosalicylic acid from aqueous medium by iron(III)-loaded magnetic chitosan/graphene oxide.
34492463	7	21	theme	spent	1208:1212	arg1	Fe-MCG					1214:1219	the spent Fe-MCG	1204:1219	the spent Fe-MCG	1204:1219	The efficacy and reusability of the spent Fe-MCG was studied using 0.01 mol/L NaOH solution.
34492463	2	22	theme	electron	406:413	arg1	SEM					427:429	SEM	427:429	SEM	427:429	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	22	theme	electron	406:413	arg1	microscopy					415:424	scanning electron microscopy	397:424	scanning electron microscopy (SEM)	397:430	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	23	with	composite	551:559	arg1	microstructure					575:588	enhanced microstructure	566:588	enhanced microstructure	566:588	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	23	with	composite	551:559	arg1	properties					612:621	superparamagnetic properties	594:621	superparamagnetic properties	594:621	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	6	24	theme	thermodynamic	1060:1072	arg1	parameters					1074:1083	the associated thermodynamic parameters	1045:1083	the associated thermodynamic parameters	1045:1083	The values obtained for the associated thermodynamic parameters confirm that the adsorptive process is spontaneous, exothermic and entropy-increasing.
34492463	2	25	theme	enhanced	566:573	arg1	microstructure					575:588	enhanced microstructure	566:588	enhanced microstructure	566:588	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	9	26	theme	hydrogen	1557:1564	arg1	forces					1517:1522	electrostatic forces	1503:1522	electrostatic forces	1503:1522	Based on the experimental results and XPS analysis, the underlying mechanisms for the uptake of SSA onto Fe-MCG involve electrostatic forces, complexation, π-π stacking, and hydrogen bonding.
34492463	9	26	theme	hydrogen	1557:1564	arg1	bonding					1566:1572	hydrogen bonding	1557:1572	hydrogen bonding	1557:1572	Based on the experimental results and XPS analysis, the underlying mechanisms for the uptake of SSA onto Fe-MCG involve electrostatic forces, complexation, π-π stacking, and hydrogen bonding.
34492463	5	27	theme	kinetic	911:917	arg1	models					919:924	The Langmuir isotherm and pseudo-second-order kinetic models	865:924	models	919:924	The Langmuir isotherm and pseudo-second-order kinetic models were observed to best describe the equilibrium adsorption and kinetic processes, respectively.
34492463	10	28	theme	excellent	1588:1596	arg1	features					1598:1605	the excellent features	1584:1605	the excellent features of Fe-MCG	1584:1615	Overall, the excellent features of Fe-MCG enhance its potential as an adsorbent for the sequestration of SSA in environmental media.
34492463	6	29	theme	associated	1049:1058	arg1	parameters					1074:1083	the associated thermodynamic parameters	1045:1083	the associated thermodynamic parameters	1045:1083	The values obtained for the associated thermodynamic parameters confirm that the adsorptive process is spontaneous, exothermic and entropy-increasing.
34492463	0	30	theme	Adsorptive	0:9	arg1	removal					11:17	Adsorptive removal	0:17	Adsorptive removal of sulfosalicylic acid from aqueous medium by iron(III)	0:73	Adsorptive removal of sulfosalicylic acid from aqueous medium by iron(III)-loaded magnetic chitosan/graphene oxide.
34492463	10	31	theme	Fe-MCG	1610:1615	arg1	features					1598:1605	the excellent features	1584:1605	the excellent features of Fe-MCG	1584:1615	Overall, the excellent features of Fe-MCG enhance its potential as an adsorbent for the sequestration of SSA in environmental media.
34492463	2	32	theme	X-ray	474:478	arg1	XPS					508:510	XPS	508:510	XPS	508:510	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	32	theme	X-ray	474:478	arg1	spectroscopy					494:505	X-ray photoelectron spectroscopy	474:505	X-ray photoelectron spectroscopy (XPS)	474:511	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	4	33	theme	chemical	795:802	arg1	processes					828:836	the chemical and physical adsorption processes	791:836	the chemical and physical adsorption processes both playing active roles	791:862	The adsorption of SSA onto Fe-MCG is driven by monolayer adsorption with the chemical and physical adsorption processes both playing active roles.
34492463	8	34	theme	kinetic	1269:1275	arg1	process					1277:1283	The kinetic process	1265:1283	The kinetic process for the desorption of SSA from Fe-MCG	1265:1321	The kinetic process for the desorption of SSA from Fe-MCG is well described by the pseudo-second-order kinetic model.
34492463	1	35	theme	-loaded	143:149	arg1	Fe-MCG					195:200	Fe-MCG	195:200	Fe-MCG	195:200	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	1	35	theme	-loaded	143:149	arg1	composite					184:192	an iron(III)-loaded magnetic chitosan/graphene oxide composite	131:192	an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG)	131:201	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	0	36	theme	sulfosalicylic	22:35	arg1	acid					37:40	sulfosalicylic acid	22:40	sulfosalicylic acid	22:40	Adsorptive removal of sulfosalicylic acid from aqueous medium by iron(III)-loaded magnetic chitosan/graphene oxide.
34492463	1	37	theme	adsorptive	239:248	arg1	removal					250:256	the adsorptive removal	235:256	the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution	235:305	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	2	38	theme	superparamagnetic	594:610	arg1	properties					612:621	superparamagnetic properties	594:621	superparamagnetic properties	594:621	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	1	39	theme	magnetic	151:158	arg1	Fe-MCG					195:200	Fe-MCG	195:200	Fe-MCG	195:200	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	1	39	theme	magnetic	151:158	arg1	composite					184:192	an iron(III)-loaded magnetic chitosan/graphene oxide composite	131:192	an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG)	131:201	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	4	40	theme	physical	808:815	arg1	processes					828:836	the chemical and physical adsorption processes	791:836	the chemical and physical adsorption processes both playing active roles	791:862	The adsorption of SSA onto Fe-MCG is driven by monolayer adsorption with the chemical and physical adsorption processes both playing active roles.
34492463	8	41	theme	kinetic	1368:1374	arg1	model					1376:1380	the pseudo-second-order kinetic model	1344:1380	the pseudo-second-order kinetic model	1344:1380	The kinetic process for the desorption of SSA from Fe-MCG is well described by the pseudo-second-order kinetic model.
34492463	1	42	theme	iron	134:137	arg1	Fe-MCG					195:200	Fe-MCG	195:200	Fe-MCG	195:200	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	1	42	theme	iron	134:137	arg1	composite					184:192	an iron(III)-loaded magnetic chitosan/graphene oxide composite	131:192	an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG)	131:201	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	9	43	theme	π-π	1539:1541	arg1	stacking					1543:1550	π-π stacking	1539:1550	π-π stacking	1539:1550	Based on the experimental results and XPS analysis, the underlying mechanisms for the uptake of SSA onto Fe-MCG involve electrostatic forces, complexation, π-π stacking, and hydrogen bonding.
34492463	9	43	theme	π-π	1539:1541	arg1	forces					1517:1522	electrostatic forces	1503:1522	electrostatic forces	1503:1522	Based on the experimental results and XPS analysis, the underlying mechanisms for the uptake of SSA onto Fe-MCG involve electrostatic forces, complexation, π-π stacking, and hydrogen bonding.
34492463	1	44	theme	chitosan/graphene	160:176	arg1	Fe-MCG					195:200	Fe-MCG	195:200	Fe-MCG	195:200	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	1	44	theme	chitosan/graphene	160:176	arg1	composite					184:192	an iron(III)-loaded magnetic chitosan/graphene oxide composite	131:192	an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG)	131:201	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	4	45	dep	playing	843:849	arg1	both					838:841	both	838:841	both	838:841	The adsorption of SSA onto Fe-MCG is driven by monolayer adsorption with the chemical and physical adsorption processes both playing active roles.
34492463	1	46	theme	oxide	178:182	arg1	Fe-MCG					195:200	Fe-MCG	195:200	Fe-MCG	195:200	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	1	46	theme	oxide	178:182	arg1	composite					184:192	an iron(III)-loaded magnetic chitosan/graphene oxide composite	131:192	an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG)	131:201	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	4	47	theme	monolayer	765:773	arg1	adsorption					775:784	monolayer adsorption	765:784	monolayer adsorption with the chemical and physical adsorption processes both playing active roles	765:862	The adsorption of SSA onto Fe-MCG is driven by monolayer adsorption with the chemical and physical adsorption processes both playing active roles.
34492463	2	48	theme	characterization	361:376	arg1	microscopy					415:424	scanning electron microscopy	397:424	scanning electron microscopy (SEM)	397:430	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	48	theme	characterization	361:376	arg1	techniques					378:387	various characterization techniques	353:387	various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS)	353:511	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	48	theme	characterization	361:376	arg1	magnetometry					450:461	vibrating-sample magnetometry	433:461	vibrating-sample magnetometry (VSM)	433:467	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	48	theme	characterization	361:376	arg1	spectroscopy					494:505	X-ray photoelectron spectroscopy	474:505	X-ray photoelectron spectroscopy (XPS)	474:511	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	0	49	theme	acid	37:40	arg1	removal					11:17	Adsorptive removal	0:17	Adsorptive removal of sulfosalicylic acid from aqueous medium by iron(III)	0:73	Adsorptive removal of sulfosalicylic acid from aqueous medium by iron(III)-loaded magnetic chitosan/graphene oxide.
34492463	1	50	theme	sulfosalicylic	261:274	arg1	acid					276:279	sulfosalicylic acid	261:279	sulfosalicylic acid (SSA) in aqueous solution	261:305	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	1	50	theme	sulfosalicylic	261:274	arg1	SSA					282:284	SSA	282:284	SSA	282:284	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	1	51	from	solution	298:305	arg1	removal					250:256	the adsorptive removal	235:256	the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution	235:305	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	2	52	theme	scanning	397:404	arg1	SEM					427:429	SEM	427:429	SEM	427:429	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	52	theme	scanning	397:404	arg1	microscopy					415:424	scanning electron microscopy	397:424	scanning electron microscopy (SEM)	397:430	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	53	theme	photoelectron	480:492	arg1	XPS					508:510	XPS	508:510	XPS	508:510	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	53	theme	photoelectron	480:492	arg1	spectroscopy					494:505	X-ray photoelectron spectroscopy	474:505	X-ray photoelectron spectroscopy (XPS)	474:511	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	54	theme	various	353:359	arg1	microscopy					415:424	scanning electron microscopy	397:424	scanning electron microscopy (SEM)	397:430	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	54	theme	various	353:359	arg1	techniques					378:387	various characterization techniques	353:387	various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS)	353:511	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	54	theme	various	353:359	arg1	magnetometry					450:461	vibrating-sample magnetometry	433:461	vibrating-sample magnetometry (VSM)	433:467	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	2	54	theme	various	353:359	arg1	spectroscopy					494:505	X-ray photoelectron spectroscopy	474:505	X-ray photoelectron spectroscopy (XPS)	474:511	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	4	55	dep	processes	828:836	arg1	playing					843:849	playing	843:849	playing active roles	843:862	The adsorption of SSA onto Fe-MCG is driven by monolayer adsorption with the chemical and physical adsorption processes both playing active roles.
34492463	1	56	theme	acid	276:279	arg1	removal					250:256	the adsorptive removal	235:256	the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution	235:305	In this study, an iron(III)-loaded magnetic chitosan/graphene oxide composite (Fe-MCG) was synthesized and applied for the adsorptive removal of sulfosalicylic acid (SSA) in aqueous solution.
34492463	2	57	theme	successful	523:532	arg1	formation					534:542	the successful formation	519:542	the successful formation of the composite with enhanced microstructure and superparamagnetic properties	519:621	The results obtained from the application of various characterization techniques such as scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM), and X-ray photoelectron spectroscopy (XPS) prove the successful formation of the composite with enhanced microstructure and superparamagnetic properties.
34492463	9	58	theme	SSA	1479:1481	arg1	uptake					1469:1474	the uptake	1465:1474	the uptake of SSA onto Fe-MCG	1465:1493	Based on the experimental results and XPS analysis, the underlying mechanisms for the uptake of SSA onto Fe-MCG involve electrostatic forces, complexation, π-π stacking, and hydrogen bonding.
34492463	5	59	theme	Langmuir	869:876	arg1	isotherm					878:885	The Langmuir isotherm and pseudo-second-order kinetic models	865:924	isotherm	878:885	The Langmuir isotherm and pseudo-second-order kinetic models were observed to best describe the equilibrium adsorption and kinetic processes, respectively.
34492463	0	60	theme	aqueous	47:53	arg1	medium					55:60	aqueous medium	47:60	aqueous medium	47:60	Adsorptive removal of sulfosalicylic acid from aqueous medium by iron(III)-loaded magnetic chitosan/graphene oxide.
34492463	4	61	theme	active	851:856	arg1	roles					858:862	active roles	851:862	active roles	851:862	The adsorption of SSA onto Fe-MCG is driven by monolayer adsorption with the chemical and physical adsorption processes both playing active roles.
34492463	8	62	from	Fe-MCG	1316:1321	arg1	desorption					1293:1302	the desorption	1289:1302	the desorption of SSA from Fe-MCG	1289:1321	The kinetic process for the desorption of SSA from Fe-MCG is well described by the pseudo-second-order kinetic model.
34492463	3	63	theme	Fe-MCG	651:656	arg1	capacity					639:646	The adsorption capacity	624:646	The adsorption capacity of Fe-MCG towards SSA via batch mode	624:683	The adsorption capacity of Fe-MCG towards SSA via batch mode reaches up to 135 mg/g at 293 K.
34492463	5	64	theme	equilibrium	961:971	arg1	adsorption					973:982	the equilibrium adsorption	957:982	the equilibrium adsorption	957:982	The Langmuir isotherm and pseudo-second-order kinetic models were observed to best describe the equilibrium adsorption and kinetic processes, respectively.
34492463	9	65	theme	electrostatic	1503:1515	arg1	complexation					1525:1536	complexation	1525:1536	complexation	1525:1536	Based on the experimental results and XPS analysis, the underlying mechanisms for the uptake of SSA onto Fe-MCG involve electrostatic forces, complexation, π-π stacking, and hydrogen bonding.
34492463	9	65	theme	electrostatic	1503:1515	arg1	stacking					1543:1550	π-π stacking	1539:1550	π-π stacking	1539:1550	Based on the experimental results and XPS analysis, the underlying mechanisms for the uptake of SSA onto Fe-MCG involve electrostatic forces, complexation, π-π stacking, and hydrogen bonding.
34492463	9	65	theme	electrostatic	1503:1515	arg1	forces					1517:1522	electrostatic forces	1503:1522	electrostatic forces	1503:1522	Based on the experimental results and XPS analysis, the underlying mechanisms for the uptake of SSA onto Fe-MCG involve electrostatic forces, complexation, π-π stacking, and hydrogen bonding.
34492463	9	65	theme	electrostatic	1503:1515	arg1	bonding					1566:1572	hydrogen bonding	1557:1572	hydrogen bonding	1557:1572	Based on the experimental results and XPS analysis, the underlying mechanisms for the uptake of SSA onto Fe-MCG involve electrostatic forces, complexation, π-π stacking, and hydrogen bonding.
34492463	8	66	theme	pseudo-second-order	1348:1366	arg1	model					1376:1380	the pseudo-second-order kinetic model	1344:1380	the pseudo-second-order kinetic model	1344:1380	The kinetic process for the desorption of SSA from Fe-MCG is well described by the pseudo-second-order kinetic model.
34492463	3	67	theme	adsorption	628:637	arg1	capacity					639:646	The adsorption capacity	624:646	The adsorption capacity of Fe-MCG towards SSA via batch mode	624:683	The adsorption capacity of Fe-MCG towards SSA via batch mode reaches up to 135 mg/g at 293 K.
34492463	10	68	from	sequestration	1663:1675	arg1	media					1701:1705	environmental media	1687:1705	environmental media	1687:1705	Overall, the excellent features of Fe-MCG enhance its potential as an adsorbent for the sequestration of SSA in environmental media.
34492463	5	69	theme	pseudo-second-order	891:909	arg1	models					919:924	The Langmuir isotherm and pseudo-second-order kinetic models	865:924	models	919:924	The Langmuir isotherm and pseudo-second-order kinetic models were observed to best describe the equilibrium adsorption and kinetic processes, respectively.
34492463	4	70	with	adsorption	775:784	arg1	processes					828:836	the chemical and physical adsorption processes	791:836	the chemical and physical adsorption processes both playing active roles	791:862	The adsorption of SSA onto Fe-MCG is driven by monolayer adsorption with the chemical and physical adsorption processes both playing active roles.
34492463	10	71	theme	SSA	1680:1682	arg1	sequestration					1663:1675	the sequestration	1659:1675	the sequestration of SSA in environmental media	1659:1705	Overall, the excellent features of Fe-MCG enhance its potential as an adsorbent for the sequestration of SSA in environmental media.
34492463	6	72	theme	adsorptive	1102:1111	arg1	spontaneous					1124:1134	spontaneous	1124:1134	spontaneous	1124:1134	The values obtained for the associated thermodynamic parameters confirm that the adsorptive process is spontaneous, exothermic and entropy-increasing.
34492463	6	72	theme	adsorptive	1102:1111	arg1	process					1113:1119	the adsorptive process	1098:1119	the adsorptive process	1098:1119	The values obtained for the associated thermodynamic parameters confirm that the adsorptive process is spontaneous, exothermic and entropy-increasing.
34492463	7	73	theme	0.01 mol/L	1239:1248	arg1	solution					1255:1262	0.01 mol/L NaOH solution	1239:1262	0.01 mol/L NaOH solution	1239:1262	The efficacy and reusability of the spent Fe-MCG was studied using 0.01 mol/L NaOH solution.
34492463	5	74	theme	kinetic	988:994	arg1	processes					996:1004	kinetic processes	988:1004	kinetic processes	988:1004	The Langmuir isotherm and pseudo-second-order kinetic models were observed to best describe the equilibrium adsorption and kinetic processes, respectively.
32527530	4	0	theme	immobilized	471:481	arg1	enzyme					483:488	immobilized enzyme	471:488	immobilized enzyme	471:488	The properties of immobilized enzyme were evaluated by activity recovery, optimum pH value and temperature, and recyclability.
32527530	7	1	theme	cellulase	988:996	arg1	activity					971:978	67 % activity	966:978	67 % activity of free cellulase	966:996	The corresponding immobilized cellulase kept 67 % activity of free cellulase at pH = 4 and 60 °C, and showed a glucose productivity of 90.8 % even after 10 cycles.
32527530	7	2	theme	free	983:986	arg1	cellulase					988:996	free cellulase	983:996	free cellulase	983:996	The corresponding immobilized cellulase kept 67 % activity of free cellulase at pH = 4 and 60 °C, and showed a glucose productivity of 90.8 % even after 10 cycles.
32527530	1	3	theme	cellulase	235:243	arg1	immobilization					245:258	cellulase immobilization	235:258	cellulase immobilization	235:258	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	5	4	theme	4	688:688	arg1	value					679:683	the optimum pH value	664:683	the optimum pH value of 4 and temperature of 60 °C	664:713	The results showed that all the three kinds of immobilized cellulase did not change the optimum pH value of 4 and temperature of 60 °C, and they also exhibited good activity and reusability.
32527530	5	5	theme	immobilized	627:637	arg1	cellulase					639:647	immobilized cellulase	627:647	immobilized cellulase	627:647	The results showed that all the three kinds of immobilized cellulase did not change the optimum pH value of 4 and temperature of 60 °C, and they also exhibited good activity and reusability.
32527530	6	6	theme	porous	900:905	arg1	biochar					907:913	porous biochar	900:913	porous biochar	900:913	Especially for C@CS25 (the feeding ratio of porous biochar to chitosan was 0.5 g: 25 mg), the support retained the morphology of porous biochar well.
32527530	3	7	theme	chemical	354:361	arg1	characteristics					363:377	The chemical characteristics	350:377	The chemical characteristics	350:377	The chemical characteristics and morphology of the samples were determined by SEM, BET, FT-IR and XPS.
32527530	5	8	theme	cellulase	639:647	arg1	kinds					618:622	all the three kinds	604:622	all the three kinds of immobilized cellulase	604:647	The results showed that all the three kinds of immobilized cellulase did not change the optimum pH value of 4 and temperature of 60 °C, and they also exhibited good activity and reusability.
32527530	5	9	theme	temperature	694:704	arg1	value					679:683	the optimum pH value	664:683	the optimum pH value of 4 and temperature of 60 °C	664:713	The results showed that all the three kinds of immobilized cellulase did not change the optimum pH value of 4 and temperature of 60 °C, and they also exhibited good activity and reusability.
32527530	6	10	theme	biochar	822:828	arg1	ratio					806:810	the feeding ratio	794:810	the feeding ratio of porous biochar to chitosan	794:840	Especially for C@CS25 (the feeding ratio of porous biochar to chitosan was 0.5 g: 25 mg), the support retained the morphology of porous biochar well.
32527530	0	11	theme	cellulase	56:64	arg1	immobilization					66:79	high performance cellulase immobilization	39:79	high performance cellulase immobilization by glutaraldehyde	39:97	Porous biochar/chitosan composites for high performance cellulase immobilization by glutaraldehyde.
32527530	4	12	dep	pH	535:536	arg1	value					538:542	value	538:542	value	538:542	The properties of immobilized enzyme were evaluated by activity recovery, optimum pH value and temperature, and recyclability.
32527530	7	13	theme	%	969:969	arg1	activity					971:978	67 % activity	966:978	67 % activity of free cellulase	966:996	The corresponding immobilized cellulase kept 67 % activity of free cellulase at pH = 4 and 60 °C, and showed a glucose productivity of 90.8 % even after 10 cycles.
32527530	1	14	theme	different	194:202	arg1	CS					227:228	C@CS	225:228	C@CS	225:228	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	1	14	theme	different	194:202	arg1	chitosan					215:222	chitosan	215:222	chitosan (C@CS) for cellulase immobilization	215:258	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	1	14	theme	different	194:202	arg1	amounts					204:210	different amounts	194:210	different amounts of chitosan (C@CS) for cellulase immobilization	194:258	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	7	15	theme	%	1061:1061	arg1	productivity					1040:1051	a glucose productivity	1030:1051	a glucose productivity of 90.8 %	1030:1061	The corresponding immobilized cellulase kept 67 % activity of free cellulase at pH = 4 and 60 °C, and showed a glucose productivity of 90.8 % even after 10 cycles.
32527530	4	16	theme	optimum	527:533	arg1	pH					535:536	optimum pH value and temperature	527:558	pH	535:536	The properties of immobilized enzyme were evaluated by activity recovery, optimum pH value and temperature, and recyclability.
32527530	5	17	theme	optimum	668:674	arg1	value					679:683	the optimum pH value	664:683	the optimum pH value of 4 and temperature of 60 °C	664:713	The results showed that all the three kinds of immobilized cellulase did not change the optimum pH value of 4 and temperature of 60 °C, and they also exhibited good activity and reusability.
32527530	7	18	theme	immobilized	939:949	arg1	cellulase					951:959	The corresponding immobilized cellulase	921:959	The corresponding immobilized cellulase	921:959	The corresponding immobilized cellulase kept 67 % activity of free cellulase at pH = 4 and 60 °C, and showed a glucose productivity of 90.8 % even after 10 cycles.
32527530	6	19	dep	CS25	788:791	arg1	0.5 g					846:850	0.5 g	846:850	was 0.5 g	842:850	Especially for C@CS25 (the feeding ratio of porous biochar to chitosan was 0.5 g: 25 mg), the support retained the morphology of porous biochar well.
32527530	5	20	theme	pH	676:677	arg1	value					679:683	the optimum pH value	664:683	the optimum pH value of 4 and temperature of 60 °C	664:713	The results showed that all the three kinds of immobilized cellulase did not change the optimum pH value of 4 and temperature of 60 °C, and they also exhibited good activity and reusability.
32527530	1	21	theme	porous	114:119	arg1	biochar					121:127	porous biochar	114:127	porous biochar derived from sugarcane bagasse	114:158	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	0	22	theme	performance	44:54	arg1	immobilization					66:79	high performance cellulase immobilization	39:79	high performance cellulase immobilization by glutaraldehyde	39:97	Porous biochar/chitosan composites for high performance cellulase immobilization by glutaraldehyde.
32527530	6	23	theme	feeding	798:804	arg1	ratio					806:810	the feeding ratio	794:810	the feeding ratio of porous biochar to chitosan	794:840	Especially for C@CS25 (the feeding ratio of porous biochar to chitosan was 0.5 g: 25 mg), the support retained the morphology of porous biochar well.
32527530	1	24	theme	chitosan	215:222	arg1	CS					227:228	C@CS	225:228	C@CS	225:228	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	1	24	theme	chitosan	215:222	arg1	chitosan					215:222	chitosan	215:222	chitosan (C@CS) for cellulase immobilization	215:258	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	1	24	theme	chitosan	215:222	arg1	amounts					204:210	different amounts	194:210	different amounts of chitosan (C@CS) for cellulase immobilization	194:258	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	0	25	theme	high	39:42	arg1	immobilization					66:79	high performance cellulase immobilization	39:79	high performance cellulase immobilization by glutaraldehyde	39:97	Porous biochar/chitosan composites for high performance cellulase immobilization by glutaraldehyde.
32527530	4	26	theme	activity	508:515	arg1	recovery					517:524	activity recovery	508:524	activity recovery	508:524	The properties of immobilized enzyme were evaluated by activity recovery, optimum pH value and temperature, and recyclability.
32527530	6	27	theme	biochar	907:913	arg1	morphology					886:895	the morphology	882:895	the morphology of porous biochar	882:913	Especially for C@CS25 (the feeding ratio of porous biochar to chitosan was 0.5 g: 25 mg), the support retained the morphology of porous biochar well.
32527530	7	28	theme	corresponding	925:937	arg1	cellulase					951:959	The corresponding immobilized cellulase	921:959	The corresponding immobilized cellulase	921:959	The corresponding immobilized cellulase kept 67 % activity of free cellulase at pH = 4 and 60 °C, and showed a glucose productivity of 90.8 % even after 10 cycles.
32527530	5	29	theme	good	740:743	arg1	activity					745:752	good activity	740:752	good activity	740:752	The results showed that all the three kinds of immobilized cellulase did not change the optimum pH value of 4 and temperature of 60 °C, and they also exhibited good activity and reusability.
32527530	7	30	theme	67	966:967	arg1	%					969:969	%	969:969	%	969:969	The corresponding immobilized cellulase kept 67 % activity of free cellulase at pH = 4 and 60 °C, and showed a glucose productivity of 90.8 % even after 10 cycles.
32527530	6	31	theme	porous	815:820	arg1	biochar					822:828	porous biochar	815:828	porous biochar	815:828	Especially for C@CS25 (the feeding ratio of porous biochar to chitosan was 0.5 g: 25 mg), the support retained the morphology of porous biochar well.
32527530	3	32	theme	samples	401:407	arg1	morphology					383:392	morphology	383:392	morphology	383:392	The chemical characteristics and morphology of the samples were determined by SEM, BET, FT-IR and XPS.
32527530	3	32	theme	samples	401:407	arg1	characteristics					363:377	The chemical characteristics	350:377	The chemical characteristics	350:377	The chemical characteristics and morphology of the samples were determined by SEM, BET, FT-IR and XPS.
32527530	4	33	theme	enzyme	483:488	arg1	properties					457:466	The properties	453:466	The properties of immobilized enzyme	453:488	The properties of immobilized enzyme were evaluated by activity recovery, optimum pH value and temperature, and recyclability.
32527530	6	34	theme	@	787:787	arg1	CS25					788:791	C@CS25	786:791	C@CS25 (the feeding ratio of porous biochar to chitosan was 0.5 g: 25 mg)	786:858	Especially for C@CS25 (the feeding ratio of porous biochar to chitosan was 0.5 g: 25 mg), the support retained the morphology of porous biochar well.
32527530	1	35	theme	C	225:225	arg1	CS					227:228	C@CS	225:228	C@CS	225:228	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	1	35	theme	C	225:225	arg1	chitosan					215:222	chitosan	215:222	chitosan (C@CS) for cellulase immobilization	215:258	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	6	36	theme	C	786:786	arg1	CS25					788:791	C@CS25	786:791	C@CS25 (the feeding ratio of porous biochar to chitosan was 0.5 g: 25 mg)	786:858	Especially for C@CS25 (the feeding ratio of porous biochar to chitosan was 0.5 g: 25 mg), the support retained the morphology of porous biochar well.
32527530	1	37	theme	sugarcane	142:150	arg1	bagasse					152:158	sugarcane bagasse	142:158	sugarcane bagasse	142:158	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	1	38	theme	@	226:226	arg1	CS					227:228	C@CS	225:228	C@CS	225:228	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	1	38	theme	@	226:226	arg1	chitosan					215:222	chitosan	215:222	chitosan (C@CS) for cellulase immobilization	215:258	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	5	39	theme	60 °C	709:713	arg1	value					679:683	the optimum pH value	664:683	the optimum pH value of 4 and temperature of 60 °C	664:713	The results showed that all the three kinds of immobilized cellulase did not change the optimum pH value of 4 and temperature of 60 °C, and they also exhibited good activity and reusability.
32527530	7	40	theme	glucose	1032:1038	arg1	productivity					1040:1051	a glucose productivity	1030:1051	a glucose productivity of 90.8 %	1030:1061	The corresponding immobilized cellulase kept 67 % activity of free cellulase at pH = 4 and 60 °C, and showed a glucose productivity of 90.8 % even after 10 cycles.
32527530	1	41	attach	derived	129:135	arg2	biochar					121:127	porous biochar	114:127	porous biochar derived from sugarcane bagasse	114:158	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32527530	1	41	attach	derived	129:135	arg1	bagasse					152:158	sugarcane bagasse	142:158	sugarcane bagasse	142:158	In this work, porous biochar derived from sugarcane bagasse was prepared and then coated with different amounts of chitosan (C@CS) for cellulase immobilization.
32864898	6	0	theme	commercial	1082:1091	arg1	film					1102:1105	the commercial Tegaderm film	1078:1105	the commercial Tegaderm film	1078:1105	An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film.
32864898	8	1	theme	hydrogel	1627:1634	arg1	dressing					1636:1643	the hydrogel dressing	1623:1643	the hydrogel dressing	1623:1643	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	4	2	with	hydrogel	670:677	arg1	MXene					690:694	2 wt% MXene	684:694	2 wt% MXene (rBC/MXene-2%)	684:709	The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility.
32864898	4	2	with	hydrogel	670:677	arg1	%					708:708	rBC/MXene-2%	697:708	rBC/MXene-2%	697:708	The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility.
32864898	3	3	theme	Ti3	529:531	arg1	Tx					536:537	Ti3 C2 Tx	529:537	Ti3 C2 Tx	529:537	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	3	3	theme	Ti3	529:531	arg1	MXene					522:526	MXene	522:526	MXene (Ti3 C2 Tx )	522:539	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	1	4	theme	Traditional	186:196	arg1	dressings					204:212	Traditional wound dressings	186:212	Traditional wound dressings	186:212	Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors.
32864898	5	5	theme	%	813:813	arg1	hydrogel					815:822	the rBC/MXene-2% hydrogel	798:822	the rBC/MXene-2% hydrogel	798:822	Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity.
32864898	5	5	theme	%	813:813	arg1	Meanwhile					787:795	Meanwhile	787:795	Meanwhile	787:795	Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity.
32864898	6	6	theme	in	945:946	arg1	study					953:957	An in vivo study	942:957	An in vivo study using a rat full-thickness defect model	942:997	An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film.
32864898	8	7	theme	appealing	1429:1437	arg1	hydrogel					1414:1421	the biodegradable and electroactive rBC/MXene hydrogel	1368:1421	the biodegradable and electroactive rBC/MXene hydrogel	1368:1421	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	8	7	theme	appealing	1429:1437	arg1	candidate					1439:1447	an appealing candidate	1426:1447	an appealing candidate as a wound dressing for skin wound healing	1426:1490	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	7	8	with	coupling	1169:1176	arg1	ES					1183:1184	ES	1183:1184	ES	1183:1184	More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls.
32864898	7	8	with	coupling	1169:1176	arg1	hydrogel					1191:1198	the hydrogel	1187:1198	the hydrogel	1187:1198	More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls.
32864898	0	9	theme	Skin	137:140	arg1	Healing					148:154	Skin Wound Healing	137:154	Skin Wound Healing	137:154	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	4	10	theme	%	688:688	arg1	MXene					690:694	2 wt% MXene	684:694	2 wt% MXene (rBC/MXene-2%)	684:709	The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility.
32864898	4	10	theme	%	688:688	arg1	%					708:708	rBC/MXene-2%	697:708	rBC/MXene-2%	697:708	The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility.
32864898	6	11	dep	in	945:946	arg1	vivo					948:951	vivo	948:951	vivo	948:951	An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film.
32864898	8	12	theme	wound	1454:1458	arg1	dressing					1460:1467	a wound dressing	1452:1467	a wound dressing	1452:1467	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	0	13	theme	Electrical	162:171	arg1	Stimulation					173:183	Electrical Stimulation	162:183	Electrical Stimulation	162:183	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	3	14	theme	active	611:616	arg1	healing					629:635	active skin wound healing	611:635	active skin wound healing	611:635	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	5	15	theme	high	914:917	arg1	capacity					932:939	high water-uptake capacity	914:939	high water-uptake capacity	914:939	Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity.
32864898	0	16	theme	C2	75:76	arg1	Cellulose/MXene					54:68	Regenerated Bacterial Cellulose/MXene	32:68	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.	0:184	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	0	16	theme	C2	75:76	arg1	Tx					78:79	Ti3 C2 Tx	71:79	Ti3 C2 Tx	71:79	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	8	17	theme	wound	1478:1482	arg1	healing					1484:1490	skin wound healing	1473:1490	skin wound healing	1473:1490	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	5	18	theme	good	887:890	arg1	biodegradability					892:907	good biodegradability	887:907	good biodegradability	887:907	Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity.
32864898	6	19	theme	full-thickness	971:984	arg1	model					993:997	a rat full-thickness defect model	965:997	a rat full-thickness defect model	965:997	An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film.
32864898	4	20	theme	highest	724:730	arg1	conductivity					743:754	electrical conductivity	732:754	electrical conductivity	732:754	The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility.
32864898	7	21	dep	in	1126:1127	arg1	vitro					1129:1133	vitro	1129:1133	vitro	1129:1133	More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls.
32864898	2	22	theme	skin	404:407	arg1	behaviors					414:422	skin cell behaviors	404:422	skin cell behaviors	404:422	Electrical stimulation (ES) has been known to regulate skin cell behaviors.
32864898	0	23	theme	Wound	105:109	arg1	Dressing					111:118	Wound Dressing	105:118	Wound Dressing	105:118	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	8	24	dep	coupling	1606:1613	arg1	ES					1615:1616	ES	1615:1616	coupling ES with the hydrogel dressing	1606:1643	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	0	25	theme	Biodegradable	0:12	arg1	Hydrogel					93:100	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel	0:100	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.	0:184	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	1	26	theme	active	292:297	arg1	healing					305:311	active wound healing	292:311	active wound healing	292:311	Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors.
32864898	6	27	theme	better	1047:1052	arg1	effect					1066:1071	a better therapeutic effect	1045:1071	a better therapeutic effect than the commercial Tegaderm film	1045:1105	An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film.
32864898	8	28	theme	synergistic	1527:1537	arg1	strategy					1551:1558	an effective synergistic therapeutic strategy	1514:1558	an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing	1514:1643	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	0	29	theme	Electroactive	18:30	arg1	Hydrogel					93:100	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel	0:100	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.	0:184	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	7	30	theme	healing	1294:1300	arg1	process					1302:1308	the wound healing process	1284:1308	the wound healing process	1284:1308	More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls.
32864898	8	31	theme	biodegradable	1372:1384	arg1	hydrogel					1414:1421	the biodegradable and electroactive rBC/MXene hydrogel	1368:1421	the biodegradable and electroactive rBC/MXene hydrogel	1368:1421	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	8	31	theme	biodegradable	1372:1384	arg1	candidate					1439:1447	an appealing candidate	1426:1447	an appealing candidate as a wound dressing for skin wound healing	1426:1490	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	3	32	theme	multifunctional	445:459	arg1	hydrogels					461:469	multifunctional hydrogels	445:469	multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx )	445:539	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	7	33	theme	in	1139:1140	arg1	data					1147:1150	in vitro and in vivo data	1126:1150	in vitro and in vivo data	1126:1150	More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls.
32864898	0	34	theme	Bacterial	44:52	arg1	Cellulose/MXene					54:68	Regenerated Bacterial Cellulose/MXene	32:68	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.	0:184	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	0	34	theme	Bacterial	44:52	arg1	Tx					78:79	Ti3 C2 Tx	71:79	Ti3 C2 Tx	71:79	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	6	35	theme	rBC/MXene	1017:1025	arg1	hydrogel					1027:1034	this rBC/MXene hydrogel	1012:1034	this rBC/MXene hydrogel	1012:1034	An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film.
32864898	3	36	theme	wound	623:627	arg1	healing					629:635	active skin wound healing	611:635	active skin wound healing	611:635	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	8	37	theme	electroactive	1390:1402	arg1	hydrogel					1414:1421	the biodegradable and electroactive rBC/MXene hydrogel	1368:1421	the biodegradable and electroactive rBC/MXene hydrogel	1368:1421	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	8	37	theme	electroactive	1390:1402	arg1	candidate					1439:1447	an appealing candidate	1426:1447	an appealing candidate as a wound dressing for skin wound healing	1426:1490	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	1	38	theme	cell	333:336	arg1	behaviors					338:346	skin cell behaviors	328:346	skin cell behaviors	328:346	Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors.
32864898	8	39	theme	repair	1583:1588	arg1	process					1590:1596	wound repair process	1577:1596	wound repair process	1577:1596	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	3	40	theme	regenerated	480:490	arg1	cellulose					502:510	regenerated bacterial cellulose	480:510	regenerated bacterial cellulose (rBC)	480:516	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	3	40	theme	regenerated	480:490	arg1	rBC					513:515	rBC	513:515	rBC	513:515	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	1	41	theme	passive	240:246	arg1	processes					256:264	the passive healing processes	236:264	the passive healing processes	236:264	Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors.
32864898	7	42	theme	NIH3T3	1256:1261	arg1	cells					1263:1267	NIH3T3 cells	1256:1267	NIH3T3 cells	1256:1267	More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls.
32864898	3	43	theme	hydrogels	461:469	arg1	series					435:440	a series	433:440	a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx )	433:539	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	5	44	theme	mechanical	841:850	arg1	properties					852:861	desired mechanical properties	833:861	desired mechanical properties	833:861	Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity.
32864898	0	45	theme	Ti3	71:73	arg1	Cellulose/MXene					54:68	Regenerated Bacterial Cellulose/MXene	32:68	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.	0:184	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	0	45	theme	Ti3	71:73	arg1	Tx					78:79	Ti3 C2 Tx	71:79	Ti3 C2 Tx	71:79	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	6	46	theme	Tegaderm	1093:1100	arg1	film					1102:1105	the commercial Tegaderm film	1078:1105	the commercial Tegaderm film	1078:1105	An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film.
32864898	3	47	theme	C2	533:534	arg1	Tx					536:537	Ti3 C2 Tx	529:537	Ti3 C2 Tx	529:537	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	3	47	theme	C2	533:534	arg1	MXene					522:526	MXene	522:526	MXene (Ti3 C2 Tx )	522:539	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	4	48	dep	conductivity	743:754	arg1	the					720:722	the	720:722	the	720:722	The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility.
32864898	8	49	with	coupling	1606:1613	arg1	dressing					1636:1643	the hydrogel dressing	1623:1643	the hydrogel dressing	1623:1643	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	5	50	theme	desired	833:839	arg1	properties					852:861	desired mechanical properties	833:861	desired mechanical properties	833:861	Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity.
32864898	1	51	theme	wound	198:202	arg1	dressings					204:212	Traditional wound dressings	186:212	Traditional wound dressings	186:212	Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors.
32864898	5	52	theme	rBC/MXene-2	802:812	arg1	hydrogel					815:822	the rBC/MXene-2% hydrogel	798:822	the rBC/MXene-2% hydrogel	798:822	Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity.
32864898	5	52	theme	rBC/MXene-2	802:812	arg1	Meanwhile					787:795	Meanwhile	787:795	Meanwhile	787:795	Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity.
32864898	0	53	theme	Wound	142:146	arg1	Healing					148:154	Skin Wound Healing	137:154	Skin Wound Healing	137:154	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	4	54	theme	wt	686:687	arg1	MXene					690:694	2 wt% MXene	684:694	2 wt% MXene (rBC/MXene-2%)	684:709	The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility.
32864898	4	54	theme	wt	686:687	arg1	%					708:708	rBC/MXene-2%	697:708	rBC/MXene-2%	697:708	The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility.
32864898	8	55	theme	skin	1473:1476	arg1	healing					1484:1490	skin wound healing	1473:1490	skin wound healing	1473:1490	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	2	56	theme	Electrical	349:358	arg1	stimulation					360:370	Electrical stimulation	349:370	Electrical stimulation (ES)	349:375	Electrical stimulation (ES) has been known to regulate skin cell behaviors.
32864898	2	56	theme	Electrical	349:358	arg1	ES					373:374	ES	373:374	ES	373:374	Electrical stimulation (ES) has been known to regulate skin cell behaviors.
32864898	3	57	theme	cell	592:595	arg1	behaviors					597:605	cell behaviors	592:605	cell behaviors	592:605	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	5	58	theme	favorable	864:872	arg1	flexibility					874:884	favorable flexibility	864:884	favorable flexibility	864:884	Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity.
32864898	7	59	theme	non-ES	1326:1331	arg1	controls					1333:1340	non-ES controls	1326:1340	non-ES controls	1326:1340	More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls.
32864898	4	60	theme	composite	660:668	arg1	hydrogel					670:677	The composite hydrogel	656:677	The composite hydrogel with 2 wt% MXene (rBC/MXene-2%)	656:709	The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility.
32864898	0	61	theme	Composite	83:91	arg1	Hydrogel					93:100	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel	0:100	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.	0:184	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	6	62	theme	defect	986:991	arg1	model					993:997	a rat full-thickness defect model	965:997	a rat full-thickness defect model	965:997	An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film.
32864898	6	63	theme	rat	967:969	arg1	model					993:997	a rat full-thickness defect model	965:997	a rat full-thickness defect model	965:997	An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film.
32864898	8	64	theme	effective	1517:1525	arg1	strategy					1551:1558	an effective synergistic therapeutic strategy	1514:1558	an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing	1514:1643	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	4	65	theme	electrical	732:741	arg1	conductivity					743:754	electrical conductivity	732:754	electrical conductivity	732:754	The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility.
32864898	5	66	theme	water-uptake	919:930	arg1	capacity					932:939	high water-uptake capacity	914:939	high water-uptake capacity	914:939	Meanwhile, the rBC/MXene-2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water-uptake capacity.
32864898	6	67	theme	therapeutic	1054:1064	arg1	effect					1066:1071	a better therapeutic effect	1045:1071	a better therapeutic effect than the commercial Tegaderm film	1045:1105	An in vivo study using a rat full-thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film.
32864898	8	68	theme	therapeutic	1539:1549	arg1	strategy					1551:1558	an effective synergistic therapeutic strategy	1514:1558	an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing	1514:1643	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	7	69	dep	in	1139:1140	arg1	vivo					1142:1145	vivo	1142:1145	vivo	1142:1145	More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls.
32864898	0	70	theme	Regenerated	32:42	arg1	Cellulose/MXene					54:68	Regenerated Bacterial Cellulose/MXene	32:68	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.	0:184	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	0	70	theme	Regenerated	32:42	arg1	Tx					78:79	Ti3 C2 Tx	71:79	Ti3 C2 Tx	71:79	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	1	71	theme	wound	299:303	arg1	healing					305:311	active wound healing	292:311	active wound healing	292:311	Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors.
32864898	7	72	theme	wound	1288:1292	arg1	healing					1294:1300	the wound healing	1284:1300	the wound healing process	1284:1308	More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls.
32864898	0	73	theme	Cellulose/MXene	54:68	arg1	Hydrogel					93:100	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel	0:100	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.	0:184	Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3 C2 Tx ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation.
32864898	8	74	theme	wound	1577:1581	arg1	repair					1583:1588	wound repair	1577:1588	wound repair process	1577:1596	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	3	75	theme	skin	618:621	arg1	healing					629:635	active skin wound healing	611:635	active skin wound healing	611:635	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	2	76	theme	cell	409:412	arg1	behaviors					414:422	skin cell behaviors	404:422	skin cell behaviors	404:422	Electrical stimulation (ES) has been known to regulate skin cell behaviors.
32864898	7	77	theme	in	1126:1127	arg1	data					1147:1150	in vitro and in vivo data	1126:1150	in vitro and in vivo data	1126:1150	More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls.
32864898	1	78	theme	skin	328:331	arg1	behaviors					338:346	skin cell behaviors	328:346	skin cell behaviors	328:346	Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors.
32864898	7	79	theme	cells	1263:1267	arg1	activity					1244:1251	the proliferation activity	1226:1251	the proliferation activity of NIH3T3 cells	1226:1267	More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls.
32864898	3	80	theme	external	643:650	arg1	ES					652:653	external ES	643:653	external ES	643:653	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	8	81	theme	rBC/MXene	1404:1412	arg1	hydrogel					1414:1421	the biodegradable and electroactive rBC/MXene hydrogel	1368:1421	the biodegradable and electroactive rBC/MXene hydrogel	1368:1421	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	8	81	theme	rBC/MXene	1404:1412	arg1	candidate					1439:1447	an appealing candidate	1426:1447	an appealing candidate as a wound dressing for skin wound healing	1426:1490	This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.
32864898	3	82	theme	bacterial	492:500	arg1	cellulose					502:510	regenerated bacterial cellulose	480:510	regenerated bacterial cellulose (rBC)	480:516	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	3	82	theme	bacterial	492:500	arg1	rBC					513:515	rBC	513:515	rBC	513:515	Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3 C2 Tx ) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES.
32864898	1	83	theme	healing	248:254	arg1	processes					256:264	the passive healing processes	236:264	the passive healing processes	236:264	Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors.
32864898	7	84	theme	proliferation	1230:1242	arg1	activity					1244:1251	the proliferation activity	1226:1251	the proliferation activity of NIH3T3 cells	1226:1267	More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non-ES controls.
32864898	4	85	theme	best	764:767	arg1	biocompatibility					769:784	the best biocompatibility	760:784	the best biocompatibility	760:784	The composite hydrogel with 2 wt% MXene (rBC/MXene-2%) exhibits the highest electrical conductivity and the best biocompatibility.
34325366	2	0	theme	PB	438:439	arg1	aerogel					463:469	a Prussian blue (PB)-immobilized alginate aerogel	421:469	a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel)	421:491	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	2	0	theme	PB	438:439	arg1	aerogel					484:490	PB-alginate aerogel	472:490	PB-alginate aerogel	472:490	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	2	1	theme	simultaneous	334:345	arg1	removal					347:353	the effective and simultaneous removal	316:353	the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater	316:418	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	7	2	theme	Sr2+	1219:1222	arg1	adsorption					1224:1233	Sr2+ adsorption	1219:1233	Sr2+ adsorption onto the PB-alginate aerogel	1219:1262	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	2	3	from	seawater	411:418	arg1	removal					347:353	the effective and simultaneous removal	316:353	the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater	316:418	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	6	4	theme	Cs+	1069:1071	arg1	behaviors					1093:1101	The Cs+ and Sr2+ adsorption behaviors	1065:1101	The Cs+ and Sr2+ adsorption behaviors on the PB-alginate aerogel	1065:1128	The Cs+ and Sr2+ adsorption behaviors on the PB-alginate aerogel were systematically investigated under various conditions.
34325366	5	5	theme	PB-alginate	968:978	arg1	aerogel					980:986	the PB-alginate aerogel	964:986	the PB-alginate aerogel	964:986	The Cs+ and Sr2+ adsorption onto the PB-alginate aerogel was completed within 3 h due to the highly porous morphology of the aerogel.
34325366	2	6	theme	PB-alginate	472:482	arg1	aerogel					463:469	a Prussian blue (PB)-immobilized alginate aerogel	421:469	a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel)	421:491	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	2	6	theme	PB-alginate	472:482	arg1	aerogel					484:490	PB-alginate aerogel	472:490	PB-alginate aerogel	472:490	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	8	7	theme	real	1385:1388	arg1	seawater					1390:1397	real seawater	1385:1397	real seawater	1385:1397	137Cs and 90Sr removal tests in real seawater demonstrated the practical feasibility of the PB-alginate aerogel as an adsorbent.
34325366	4	8	theme	Sr2+	743:746	arg1	capacities					759:768	Cs+ and Sr2+ adsorption capacities	735:768	Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g	735:792	The PB-alginate aerogel exhibited Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g, respectively, without substantial interference because Cs+ and Sr2+ adsorption occurred at different adsorption sites on the composite.
34325366	3	9	with	contact	678:684	arg1	seawater					691:698	seawater	691:698	seawater	691:698	PB nanoparticles were homogeneously dispersed in the three-dimensional porous alginate aerogel matrix, which enabled facile contact with seawater.
34325366	1	10	theme	Fukushima	248:256	arg1	accident					258:265	the Fukushima accident	244:265	the Fukushima accident in 2011 due to their long-term health risks	244:309	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	0	11	theme	efficient	86:94	arg1	Prussian					96:103	a highly efficient Prussian	77:103	a highly efficient Prussian	77:103	Simultaneous removal of radioactive cesium and strontium from seawater using a highly efficient Prussian blue-embedded alginate aerogel.
34325366	7	12	from	cations	1306:1312	arg1	seawater					1343:1350	seawater	1343:1350	seawater	1343:1350	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	7	13	theme	PB-alginate	1244:1254	arg1	aerogel					1256:1262	the PB-alginate aerogel	1240:1262	the PB-alginate aerogel	1240:1262	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	8	14	from	tests	1376:1380	arg1	seawater					1390:1397	real seawater	1385:1397	real seawater	1385:1397	137Cs and 90Sr removal tests in real seawater demonstrated the practical feasibility of the PB-alginate aerogel as an adsorbent.
34325366	0	15	theme	alginate	119:126	arg1	aerogel					128:134	alginate aerogel	119:134	alginate aerogel	119:134	Simultaneous removal of radioactive cesium and strontium from seawater using a highly efficient Prussian blue-embedded alginate aerogel.
34325366	6	16	theme	PB-alginate	1110:1120	arg1	aerogel					1122:1128	the PB-alginate aerogel	1106:1128	the PB-alginate aerogel	1106:1128	The Cs+ and Sr2+ adsorption behaviors on the PB-alginate aerogel were systematically investigated under various conditions.
34325366	6	17	theme	various	1169:1175	arg1	conditions					1177:1186	various conditions	1169:1186	various conditions	1169:1186	The Cs+ and Sr2+ adsorption behaviors on the PB-alginate aerogel were systematically investigated under various conditions.
34325366	1	18	theme	strontium	168:176	arg1	problem					230:236	a serious problem	220:236	a serious problem since the Fukushima accident in 2011 due to their long-term health risks	220:309	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	1	18	theme	strontium	168:176	arg1	contaminants					185:196	Radioactive cesium (137Cs) and strontium (90Sr) contaminants	137:196	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater	137:208	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	2	19	theme	alginate	454:461	arg1	aerogel					463:469	a Prussian blue (PB)-immobilized alginate aerogel	421:469	a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel)	421:491	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	2	19	theme	alginate	454:461	arg1	aerogel					484:490	PB-alginate aerogel	472:490	PB-alginate aerogel	472:490	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	4	20	theme	substantial	817:827	arg1	interference					829:840	substantial interference	817:840	substantial interference	817:840	The PB-alginate aerogel exhibited Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g, respectively, without substantial interference because Cs+ and Sr2+ adsorption occurred at different adsorption sites on the composite.
34325366	7	21	theme	Cs+	1203:1205	arg1	adsorption					1207:1216	Cs+ adsorption	1203:1216	Cs+ adsorption	1203:1216	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	4	22	theme	adsorption	748:757	arg1	capacities					759:768	Cs+ and Sr2+ adsorption capacities	735:768	Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g	735:792	The PB-alginate aerogel exhibited Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g, respectively, without substantial interference because Cs+ and Sr2+ adsorption occurred at different adsorption sites on the composite.
34325366	4	23	dep	Cs+	850:852	arg1	adsorption					863:872	adsorption	863:872	adsorption	863:872	The PB-alginate aerogel exhibited Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g, respectively, without substantial interference because Cs+ and Sr2+ adsorption occurred at different adsorption sites on the composite.
34325366	2	24	theme	cesium	370:375	arg1	removal					347:353	the effective and simultaneous removal	316:353	the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater	316:418	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	0	25	theme	Simultaneous	0:11	arg1	removal					13:19	Simultaneous removal	0:19	Simultaneous removal of radioactive cesium and strontium from seawater using a highly efficient Prussian	0:103	Simultaneous removal of radioactive cesium and strontium from seawater using a highly efficient Prussian blue-embedded alginate aerogel.
34325366	8	26	theme	aerogel	1457:1463	arg1	feasibility					1426:1436	the practical feasibility	1412:1436	the practical feasibility of the PB-alginate aerogel	1412:1463	137Cs and 90Sr removal tests in real seawater demonstrated the practical feasibility of the PB-alginate aerogel as an adsorbent.
34325366	8	26	theme	aerogel	1457:1463	arg1	adsorbent					1471:1479	adsorbent	1471:1479	adsorbent	1471:1479	137Cs and 90Sr removal tests in real seawater demonstrated the practical feasibility of the PB-alginate aerogel as an adsorbent.
34325366	4	27	theme	PB-alginate	705:715	arg1	aerogel					717:723	The PB-alginate aerogel	701:723	The PB-alginate aerogel	701:723	The PB-alginate aerogel exhibited Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g, respectively, without substantial interference because Cs+ and Sr2+ adsorption occurred at different adsorption sites on the composite.
34325366	2	28	theme	radioactive	358:368	arg1	137Cs					378:382	137Cs	378:382	137Cs	378:382	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	2	28	theme	radioactive	358:368	arg1	cesium					370:375	radioactive cesium	358:375	radioactive cesium (137Cs)	358:383	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	0	29	theme	radioactive	24:34	arg1	cesium					36:41	radioactive cesium	24:41	radioactive cesium	24:41	Simultaneous removal of radioactive cesium and strontium from seawater using a highly efficient Prussian blue-embedded alginate aerogel.
34325366	4	30	theme	Cs+	735:737	arg1	capacities					759:768	Cs+ and Sr2+ adsorption capacities	735:768	Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g	735:792	The PB-alginate aerogel exhibited Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g, respectively, without substantial interference because Cs+ and Sr2+ adsorption occurred at different adsorption sites on the composite.
34325366	5	31	theme	Cs+	935:937	arg1	adsorption					948:957	The Cs+ and Sr2+ adsorption	931:957	The Cs+ and Sr2+ adsorption onto the PB-alginate aerogel	931:986	The Cs+ and Sr2+ adsorption onto the PB-alginate aerogel was completed within 3 h due to the highly porous morphology of the aerogel.
34325366	1	32	theme	due	275:277	arg1	2011					270:273	2011	270:273	2011 due to their long-term health risks	270:309	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	1	33	from	accident	258:265	arg1	2011					270:273	2011	270:273	2011 due to their long-term health risks	270:309	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	3	34	theme	three-dimensional	607:623	arg1	matrix					649:654	the three-dimensional porous alginate aerogel matrix	603:654	the three-dimensional porous alginate aerogel matrix	603:654	PB nanoparticles were homogeneously dispersed in the three-dimensional porous alginate aerogel matrix, which enabled facile contact with seawater.
34325366	5	35	theme	Sr2+	943:946	arg1	adsorption					948:957	The Cs+ and Sr2+ adsorption	931:957	The Cs+ and Sr2+ adsorption onto the PB-alginate aerogel	931:986	The Cs+ and Sr2+ adsorption onto the PB-alginate aerogel was completed within 3 h due to the highly porous morphology of the aerogel.
34325366	2	36	theme	strontium	389:397	arg1	removal					347:353	the effective and simultaneous removal	316:353	the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater	316:418	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	2	37	theme	blue	432:435	arg1	aerogel					463:469	a Prussian blue (PB)-immobilized alginate aerogel	421:469	a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel)	421:491	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	2	37	theme	blue	432:435	arg1	aerogel					484:490	PB-alginate aerogel	472:490	PB-alginate aerogel	472:490	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	3	38	theme	porous	625:630	arg1	matrix					649:654	the three-dimensional porous alginate aerogel matrix	603:654	the three-dimensional porous alginate aerogel matrix	603:654	PB nanoparticles were homogeneously dispersed in the three-dimensional porous alginate aerogel matrix, which enabled facile contact with seawater.
34325366	8	39	theme	90Sr	1363:1366	arg1	tests					1376:1380	137Cs and 90Sr removal tests	1353:1380	137Cs and 90Sr removal tests in real seawater	1353:1397	137Cs and 90Sr removal tests in real seawater demonstrated the practical feasibility of the PB-alginate aerogel as an adsorbent.
34325366	7	40	theme	competing	1296:1304	arg1	K+					1336:1337	K+	1336:1337	K+	1336:1337	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	7	40	theme	competing	1296:1304	arg1	Mg2+					1320:1323	Mg2+	1320:1323	Mg2+	1320:1323	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	7	40	theme	competing	1296:1304	arg1	Na+					1315:1317	Na+	1315:1317	Na+	1315:1317	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	7	40	theme	competing	1296:1304	arg1	cations					1306:1312	competing cations	1296:1312	competing cations (Na+, Mg2+, Ca2+, and K+) in seawater	1296:1350	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	7	40	theme	competing	1296:1304	arg1	Ca2+					1326:1329	Ca2+	1326:1329	Ca2+	1326:1329	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	2	41	theme	Prussian	423:430	arg1	aerogel					463:469	a Prussian blue (PB)-immobilized alginate aerogel	421:469	a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel)	421:491	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	2	41	theme	Prussian	423:430	arg1	aerogel					484:490	PB-alginate aerogel	472:490	PB-alginate aerogel	472:490	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	0	42	theme	cesium	36:41	arg1	removal					13:19	Simultaneous removal	0:19	Simultaneous removal of radioactive cesium and strontium from seawater using a highly efficient Prussian	0:103	Simultaneous removal of radioactive cesium and strontium from seawater using a highly efficient Prussian blue-embedded alginate aerogel.
34325366	3	43	theme	PB	554:555	arg1	nanoparticles					557:569	PB nanoparticles	554:569	PB nanoparticles	554:569	PB nanoparticles were homogeneously dispersed in the three-dimensional porous alginate aerogel matrix, which enabled facile contact with seawater.
34325366	8	44	theme	practical	1416:1424	arg1	feasibility					1426:1436	the practical feasibility	1412:1436	the practical feasibility of the PB-alginate aerogel	1412:1463	137Cs and 90Sr removal tests in real seawater demonstrated the practical feasibility of the PB-alginate aerogel as an adsorbent.
34325366	8	44	theme	practical	1416:1424	arg1	adsorbent					1471:1479	adsorbent	1471:1479	adsorbent	1471:1479	137Cs and 90Sr removal tests in real seawater demonstrated the practical feasibility of the PB-alginate aerogel as an adsorbent.
34325366	8	45	theme	PB-alginate	1445:1455	arg1	aerogel					1457:1463	the PB-alginate aerogel	1441:1463	the PB-alginate aerogel	1441:1463	137Cs and 90Sr removal tests in real seawater demonstrated the practical feasibility of the PB-alginate aerogel as an adsorbent.
34325366	1	46	theme	long-term	288:296	arg1	risks					305:309	their long-term health risks	282:309	their long-term health risks	282:309	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	4	47	theme	different	886:894	arg1	sites					907:911	different adsorption sites	886:911	different adsorption sites on the composite	886:928	The PB-alginate aerogel exhibited Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g, respectively, without substantial interference because Cs+ and Sr2+ adsorption occurred at different adsorption sites on the composite.
34325366	0	48	from	seawater	62:69	arg1	removal					13:19	Simultaneous removal	0:19	Simultaneous removal of radioactive cesium and strontium from seawater using a highly efficient Prussian	0:103	Simultaneous removal of radioactive cesium and strontium from seawater using a highly efficient Prussian blue-embedded alginate aerogel.
34325366	6	49	from	behaviors	1093:1101	arg1	aerogel					1122:1128	the PB-alginate aerogel	1106:1128	the PB-alginate aerogel	1106:1128	The Cs+ and Sr2+ adsorption behaviors on the PB-alginate aerogel were systematically investigated under various conditions.
34325366	2	50	theme	effective	320:328	arg1	removal					347:353	the effective and simultaneous removal	316:353	the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater	316:418	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	0	51	theme	strontium	47:55	arg1	removal					13:19	Simultaneous removal	0:19	Simultaneous removal of radioactive cesium and strontium from seawater using a highly efficient Prussian	0:103	Simultaneous removal of radioactive cesium and strontium from seawater using a highly efficient Prussian blue-embedded alginate aerogel.
34325366	1	52	theme	health	298:303	arg1	risks					305:309	their long-term health risks	282:309	their long-term health risks	282:309	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	2	53	theme	adsorption	516:525	arg1	performance					527:537	its adsorption performance	512:537	its adsorption performance	512:537	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	4	54	from	sites	907:911	arg1	composite					920:928	the composite	916:928	the composite	916:928	The PB-alginate aerogel exhibited Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g, respectively, without substantial interference because Cs+ and Sr2+ adsorption occurred at different adsorption sites on the composite.
34325366	8	55	theme	removal	1368:1374	arg1	tests					1376:1380	137Cs and 90Sr removal tests	1353:1380	137Cs and 90Sr removal tests in real seawater	1353:1397	137Cs and 90Sr removal tests in real seawater demonstrated the practical feasibility of the PB-alginate aerogel as an adsorbent.
34325366	1	56	from	contaminants	185:196	arg1	seawater					201:208	seawater	201:208	seawater	201:208	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	5	57	theme	porous	1031:1036	arg1	morphology					1038:1047	the highly porous morphology	1020:1047	the highly porous morphology of the aerogel	1020:1062	The Cs+ and Sr2+ adsorption onto the PB-alginate aerogel was completed within 3 h due to the highly porous morphology of the aerogel.
34325366	4	58	theme	19.88	773:777	arg1	capacities					759:768	Cs+ and Sr2+ adsorption capacities	735:768	Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g	735:792	The PB-alginate aerogel exhibited Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g, respectively, without substantial interference because Cs+ and Sr2+ adsorption occurred at different adsorption sites on the composite.
34325366	1	59	theme	Radioactive	137:147	arg1	137Cs					157:161	137Cs	157:161	137Cs	157:161	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	1	59	theme	Radioactive	137:147	arg1	cesium					149:154	Radioactive cesium	137:154	Radioactive cesium (137Cs)	137:162	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	8	60	theme	137Cs	1353:1357	arg1	tests					1376:1380	137Cs and 90Sr removal tests	1353:1380	137Cs and 90Sr removal tests in real seawater	1353:1397	137Cs and 90Sr removal tests in real seawater demonstrated the practical feasibility of the PB-alginate aerogel as an adsorbent.
34325366	4	61	theme	adsorption	896:905	arg1	sites					907:911	different adsorption sites	886:911	different adsorption sites on the composite	886:928	The PB-alginate aerogel exhibited Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g, respectively, without substantial interference because Cs+ and Sr2+ adsorption occurred at different adsorption sites on the composite.
34325366	3	62	theme	alginate	632:639	arg1	matrix					649:654	the three-dimensional porous alginate aerogel matrix	603:654	the three-dimensional porous alginate aerogel matrix	603:654	PB nanoparticles were homogeneously dispersed in the three-dimensional porous alginate aerogel matrix, which enabled facile contact with seawater.
34325366	7	63	dep	cations	1306:1312	arg1	K+					1336:1337	K+	1336:1337	K+	1336:1337	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	7	63	dep	cations	1306:1312	arg1	Mg2+					1320:1323	Mg2+	1320:1323	Mg2+	1320:1323	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	7	63	dep	cations	1306:1312	arg1	Na+					1315:1317	Na+	1315:1317	Na+	1315:1317	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	7	63	dep	cations	1306:1312	arg1	cations					1306:1312	competing cations	1296:1312	competing cations (Na+, Mg2+, Ca2+, and K+) in seawater	1296:1350	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	7	63	dep	cations	1306:1312	arg1	Ca2+					1326:1329	Ca2+	1326:1329	Ca2+	1326:1329	Compared with Cs+ adsorption, Sr2+ adsorption onto the PB-alginate aerogel was more strongly influenced by competing cations (Na+, Mg2+, Ca2+, and K+) in seawater.
34325366	5	64	theme	aerogel	1056:1062	arg1	morphology					1038:1047	the highly porous morphology	1020:1047	the highly porous morphology of the aerogel	1020:1062	The Cs+ and Sr2+ adsorption onto the PB-alginate aerogel was completed within 3 h due to the highly porous morphology of the aerogel.
34325366	1	65	theme	cesium	149:154	arg1	problem					230:236	a serious problem	220:236	a serious problem since the Fukushima accident in 2011 due to their long-term health risks	220:309	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	1	65	theme	cesium	149:154	arg1	contaminants					185:196	Radioactive cesium (137Cs) and strontium (90Sr) contaminants	137:196	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater	137:208	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	2	66	theme	-immobilized	441:452	arg1	aerogel					463:469	a Prussian blue (PB)-immobilized alginate aerogel	421:469	a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel)	421:491	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	2	66	theme	-immobilized	441:452	arg1	aerogel					484:490	PB-alginate aerogel	472:490	PB-alginate aerogel	472:490	For the effective and simultaneous removal of radioactive cesium (137Cs) and strontium (90Sr) from seawater, a Prussian blue (PB)-immobilized alginate aerogel (PB-alginate aerogel) was fabricated and its adsorption performance was evaluated.
34325366	3	67	theme	aerogel	641:647	arg1	matrix					649:654	the three-dimensional porous alginate aerogel matrix	603:654	the three-dimensional porous alginate aerogel matrix	603:654	PB nanoparticles were homogeneously dispersed in the three-dimensional porous alginate aerogel matrix, which enabled facile contact with seawater.
34325366	4	68	theme	20.10 mg/g	783:792	arg1	capacities					759:768	Cs+ and Sr2+ adsorption capacities	735:768	Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g	735:792	The PB-alginate aerogel exhibited Cs+ and Sr2+ adsorption capacities of 19.88 and 20.10 mg/g, respectively, without substantial interference because Cs+ and Sr2+ adsorption occurred at different adsorption sites on the composite.
34325366	6	69	theme	adsorption	1082:1091	arg1	behaviors					1093:1101	The Cs+ and Sr2+ adsorption behaviors	1065:1101	The Cs+ and Sr2+ adsorption behaviors on the PB-alginate aerogel	1065:1128	The Cs+ and Sr2+ adsorption behaviors on the PB-alginate aerogel were systematically investigated under various conditions.
34325366	1	70	theme	serious	222:228	arg1	problem					230:236	a serious problem	220:236	a serious problem since the Fukushima accident in 2011 due to their long-term health risks	220:309	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	1	70	theme	serious	222:228	arg1	contaminants					185:196	Radioactive cesium (137Cs) and strontium (90Sr) contaminants	137:196	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater	137:208	Radioactive cesium (137Cs) and strontium (90Sr) contaminants in seawater have been a serious problem since the Fukushima accident in 2011 due to their long-term health risks.
34325366	3	71	theme	facile	671:676	arg1	contact					678:684	facile contact	671:684	facile contact with seawater	671:698	PB nanoparticles were homogeneously dispersed in the three-dimensional porous alginate aerogel matrix, which enabled facile contact with seawater.
34325366	6	72	theme	Sr2+	1077:1080	arg1	behaviors					1093:1101	The Cs+ and Sr2+ adsorption behaviors	1065:1101	The Cs+ and Sr2+ adsorption behaviors on the PB-alginate aerogel	1065:1128	The Cs+ and Sr2+ adsorption behaviors on the PB-alginate aerogel were systematically investigated under various conditions.
33428950	8	0	theme	moisture	939:946	arg1	capacity					959:966	The moisture absorption capacity	935:966	The moisture absorption capacity	935:966	The moisture absorption capacity and water vapor permeability were 40.56% and 51.43% lower than those of the pure-PLA film.
33428950	8	0	theme	moisture	939:946	arg1	lower					1020:1024	lower	1020:1024	lower	1020:1024	The moisture absorption capacity and water vapor permeability were 40.56% and 51.43% lower than those of the pure-PLA film.
33428950	8	1	theme	vapor	978:982	arg1	permeability					984:995	water vapor permeability	972:995	water vapor permeability	972:995	The moisture absorption capacity and water vapor permeability were 40.56% and 51.43% lower than those of the pure-PLA film.
33428950	2	2	theme	acid	312:315	arg1	concentration					317:329	formic acid concentration	305:329	formic acid concentration	305:329	The amount of formyl groups in FC was adjusted by controlling the reaction time, reaction temperature, and formic acid concentration.
33428950	8	3	theme	water	972:976	arg1	permeability					984:995	water vapor permeability	972:995	water vapor permeability	972:995	The moisture absorption capacity and water vapor permeability were 40.56% and 51.43% lower than those of the pure-PLA film.
33428950	4	4	theme	short	518:522	arg1	rods					524:527	short rods	518:527	short rods	518:527	Scanning electron microscopy (SEM) shows that long rod-like cellulose particles were broken into short rods after formylation and the introduction of FC made PLA surface rougher.
33428950	0	5	theme	mechanical	66:75	arg1	properties					89:98	the mechanical and barrier properties	62:98	properties	89:98	Preparation of formyl cellulose and its enhancement effect on the mechanical and barrier properties of polylactic acid films.
33428950	6	6	theme	%	795:795	arg1	increase					797:804	a 48.59% increase	788:804	a 48.59% increase in tensile strength	788:824	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	6	7	with	film	728:731	arg1	FC					744:745	1 wt% FC	738:745	1 wt% FC (containing 15.79% formyl groups)	738:779	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	1	8	theme	formic	152:157	arg1	acid					159:162	formic acid	152:162	formic acid to prepare formyl cellulose (FC)	152:195	Cellulose was modified by formic acid to prepare formyl cellulose (FC).
33428950	1	8	theme	formic	152:157	arg1	FC					193:194	FC	193:194	FC	193:194	Cellulose was modified by formic acid to prepare formyl cellulose (FC).
33428950	5	9	theme	films	636:640	arg1	properties					615:624	The mechanical properties	600:624	The mechanical properties of PLA/FC films	600:640	The mechanical properties of PLA/FC films were improved by the inclusion of FC.
33428950	7	10	theme	better	902:907	arg1	properties					923:932	better water barrier properties	902:932	better water barrier properties	902:932	The addition of FC also resulted in better water barrier properties.
33428950	0	11	from	Preparation	0:10	arg1	properties					89:98	the mechanical and barrier properties	62:98	properties	89:98	Preparation of formyl cellulose and its enhancement effect on the mechanical and barrier properties of polylactic acid films.
33428950	9	12	with	compatibility	1145:1157	arg1	introduction					1194:1205	the introduction	1190:1205	the introduction of hydrophobic formate groups	1190:1235	The enhancement in properties for PLA/FC composites could be ascribed to the improved compatibility between PLA and cellulose with the introduction of hydrophobic formate groups.
33428950	10	13	theme	PLA/FC	1242:1247	arg1	potential					1304:1312	potential	1304:1312	potential	1304:1312	The PLA/FC composite films developed in this work could be highly potential for food packaging.
33428950	10	13	theme	PLA/FC	1242:1247	arg1	films					1259:1263	The PLA/FC composite films	1238:1263	The PLA/FC composite films developed in this work	1238:1286	The PLA/FC composite films developed in this work could be highly potential for food packaging.
33428950	0	14	theme	barrier	81:87	arg1	properties					89:98	the mechanical and barrier properties	62:98	properties	89:98	Preparation of formyl cellulose and its enhancement effect on the mechanical and barrier properties of polylactic acid films.
33428950	0	15	from	effect	52:57	arg1	properties					89:98	the mechanical and barrier properties	62:98	properties	89:98	Preparation of formyl cellulose and its enhancement effect on the mechanical and barrier properties of polylactic acid films.
33428950	6	16	theme	composite	718:726	arg1	film					728:731	the PLA/FC composite film	707:731	the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups)	707:779	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	6	17	theme	Young	849:853	arg1	modulus					857:863	Young's modulus	849:863	Young's modulus	849:863	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	0	18	theme	polylactic	103:112	arg1	films					119:123	polylactic acid films	103:123	polylactic acid films	103:123	Preparation of formyl cellulose and its enhancement effect on the mechanical and barrier properties of polylactic acid films.
33428950	6	19	theme	PLA/FC	711:716	arg1	film					728:731	the PLA/FC composite film	707:731	the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups)	707:779	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	5	20	theme	FC	676:677	arg1	inclusion					663:671	the inclusion	659:671	the inclusion of FC	659:677	The mechanical properties of PLA/FC films were improved by the inclusion of FC.
33428950	4	21	theme	electron	430:437	arg1	SEM					451:453	SEM	451:453	SEM	451:453	Scanning electron microscopy (SEM) shows that long rod-like cellulose particles were broken into short rods after formylation and the introduction of FC made PLA surface rougher.
33428950	4	21	theme	electron	430:437	arg1	microscopy					439:448	Scanning electron microscopy	421:448	Scanning electron microscopy (SEM)	421:454	Scanning electron microscopy (SEM) shows that long rod-like cellulose particles were broken into short rods after formylation and the introduction of FC made PLA surface rougher.
33428950	9	22	theme	groups	1230:1235	arg1	introduction					1194:1205	the introduction	1190:1205	the introduction of hydrophobic formate groups	1190:1235	The enhancement in properties for PLA/FC composites could be ascribed to the improved compatibility between PLA and cellulose with the introduction of hydrophobic formate groups.
33428950	4	23	theme	surface	583:589	arg1	rougher					591:597	PLA surface rougher	579:597	PLA surface rougher	579:597	Scanning electron microscopy (SEM) shows that long rod-like cellulose particles were broken into short rods after formylation and the introduction of FC made PLA surface rougher.
33428950	4	24	theme	Scanning	421:428	arg1	SEM					451:453	SEM	451:453	SEM	451:453	Scanning electron microscopy (SEM) shows that long rod-like cellulose particles were broken into short rods after formylation and the introduction of FC made PLA surface rougher.
33428950	4	24	theme	Scanning	421:428	arg1	microscopy					439:448	Scanning electron microscopy	421:448	Scanning electron microscopy (SEM)	421:454	Scanning electron microscopy (SEM) shows that long rod-like cellulose particles were broken into short rods after formylation and the introduction of FC made PLA surface rougher.
33428950	10	25	theme	food	1318:1321	arg1	packaging					1323:1331	food packaging	1318:1331	food packaging	1318:1331	The PLA/FC composite films developed in this work could be highly potential for food packaging.
33428950	2	26	from	amount	202:207	arg1	FC					229:230	FC	229:230	FC	229:230	The amount of formyl groups in FC was adjusted by controlling the reaction time, reaction temperature, and formic acid concentration.
33428950	3	27	theme	acid	374:377	arg1	films					385:389	polylactic acid (PLA) films	363:389	polylactic acid (PLA) films prepared by solution casting	363:418	Then, FC was used to reinforce polylactic acid (PLA) films prepared by solution casting.
33428950	9	28	theme	improved	1136:1143	arg1	compatibility					1145:1157	the improved compatibility	1132:1157	the improved compatibility between PLA and cellulose with the introduction of hydrophobic formate groups	1132:1235	The enhancement in properties for PLA/FC composites could be ascribed to the improved compatibility between PLA and cellulose with the introduction of hydrophobic formate groups.
33428950	7	29	theme	barrier	915:921	arg1	properties					923:932	better water barrier properties	902:932	better water barrier properties	902:932	The addition of FC also resulted in better water barrier properties.
33428950	1	30	theme	formyl	175:180	arg1	cellulose					182:190	formyl cellulose	175:190	formyl cellulose	175:190	Cellulose was modified by formic acid to prepare formyl cellulose (FC).
33428950	0	31	theme	cellulose	22:30	arg1	Preparation					0:10	Preparation	0:10	Preparation of formyl cellulose	0:30	Preparation of formyl cellulose and its enhancement effect on the mechanical and barrier properties of polylactic acid films.
33428950	0	31	theme	cellulose	22:30	arg1	effect					52:57	its enhancement effect	36:57	its enhancement effect on the mechanical and barrier properties of polylactic acid films	36:123	Preparation of formyl cellulose and its enhancement effect on the mechanical and barrier properties of polylactic acid films.
33428950	4	32	theme	cellulose	481:489	arg1	particles					491:499	long rod-like cellulose particles	467:499	long rod-like cellulose particles	467:499	Scanning electron microscopy (SEM) shows that long rod-like cellulose particles were broken into short rods after formylation and the introduction of FC made PLA surface rougher.
33428950	0	33	theme	films	119:123	arg1	properties					89:98	the mechanical and barrier properties	62:98	properties	89:98	Preparation of formyl cellulose and its enhancement effect on the mechanical and barrier properties of polylactic acid films.
33428950	6	34	theme	PLA	697:699	arg1	film					701:704	pure PLA film	692:704	pure PLA film	692:704	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	2	35	theme	reaction	264:271	arg1	time					273:276	the reaction time	260:276	the reaction time	260:276	The amount of formyl groups in FC was adjusted by controlling the reaction time, reaction temperature, and formic acid concentration.
33428950	4	36	theme	FC	571:572	arg1	introduction					555:566	the introduction	551:566	the introduction of FC	551:572	Scanning electron microscopy (SEM) shows that long rod-like cellulose particles were broken into short rods after formylation and the introduction of FC made PLA surface rougher.
33428950	0	37	theme	formyl	15:20	arg1	cellulose					22:30	formyl cellulose	15:30	formyl cellulose	15:30	Preparation of formyl cellulose and its enhancement effect on the mechanical and barrier properties of polylactic acid films.
33428950	6	38	theme	%	835:835	arg1	increase					837:844	a 346% increase	830:844	a 346% increase in Young's modulus	830:863	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	0	39	theme	acid	114:117	arg1	films					119:123	polylactic acid films	103:123	polylactic acid films	103:123	Preparation of formyl cellulose and its enhancement effect on the mechanical and barrier properties of polylactic acid films.
33428950	6	40	theme	formyl	766:771	arg1	groups					773:778	15.79% formyl groups	759:778	15.79% formyl groups	759:778	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	2	41	theme	formic	305:310	arg1	acid					312:315	formic acid	305:315	formic acid concentration	305:329	The amount of formyl groups in FC was adjusted by controlling the reaction time, reaction temperature, and formic acid concentration.
33428950	3	42	theme	solution	403:410	arg1	casting					412:418	solution casting	403:418	solution casting	403:418	Then, FC was used to reinforce polylactic acid (PLA) films prepared by solution casting.
33428950	6	43	theme	346	832:834	arg1	%					835:835	%	835:835	%	835:835	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	7	44	theme	water	909:913	arg1	properties					923:932	better water barrier properties	902:932	better water barrier properties	902:932	The addition of FC also resulted in better water barrier properties.
33428950	4	45	theme	PLA	579:581	arg1	rougher					591:597	PLA surface rougher	579:597	PLA surface rougher	579:597	Scanning electron microscopy (SEM) shows that long rod-like cellulose particles were broken into short rods after formylation and the introduction of FC made PLA surface rougher.
33428950	1	46	mod	modified	140:147	arg3	acid					159:162	formic acid	152:162	formic acid to prepare formyl cellulose (FC)	152:195	Cellulose was modified by formic acid to prepare formyl cellulose (FC).
33428950	1	46	mod	modified	140:147	arg1	Cellulose					126:134	Cellulose	126:134	Cellulose	126:134	Cellulose was modified by formic acid to prepare formyl cellulose (FC).
33428950	1	46	mod	modified	140:147	arg3	FC					193:194	FC	193:194	FC	193:194	Cellulose was modified by formic acid to prepare formyl cellulose (FC).
33428950	3	47	theme	polylactic	363:372	arg1	PLA					380:382	PLA	380:382	PLA	380:382	Then, FC was used to reinforce polylactic acid (PLA) films prepared by solution casting.
33428950	3	47	theme	polylactic	363:372	arg1	acid					374:377	polylactic acid	363:377	polylactic acid (PLA) films prepared by solution casting	363:418	Then, FC was used to reinforce polylactic acid (PLA) films prepared by solution casting.
33428950	9	48	theme	hydrophobic	1210:1220	arg1	groups					1230:1235	hydrophobic formate groups	1210:1235	hydrophobic formate groups	1210:1235	The enhancement in properties for PLA/FC composites could be ascribed to the improved compatibility between PLA and cellulose with the introduction of hydrophobic formate groups.
33428950	6	49	from	increase	837:844	arg1	strength					817:824	tensile strength	809:824	tensile strength	809:824	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	6	50	theme	15.79	759:763	arg1	%					764:764	%	764:764	%	764:764	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	8	51	theme	pure-PLA	1044:1051	arg1	film					1053:1056	the pure-PLA film	1040:1056	the pure-PLA film	1040:1056	The moisture absorption capacity and water vapor permeability were 40.56% and 51.43% lower than those of the pure-PLA film.
33428950	6	52	theme	pure	692:695	arg1	film					701:704	pure PLA film	692:704	pure PLA film	692:704	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	6	53	theme	tensile	809:815	arg1	strength					817:824	tensile strength	809:824	tensile strength	809:824	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	9	54	theme	formate	1222:1228	arg1	groups					1230:1235	hydrophobic formate groups	1210:1235	hydrophobic formate groups	1210:1235	The enhancement in properties for PLA/FC composites could be ascribed to the improved compatibility between PLA and cellulose with the introduction of hydrophobic formate groups.
33428950	5	55	theme	mechanical	604:613	arg1	properties					615:624	The mechanical properties	600:624	The mechanical properties of PLA/FC films	600:640	The mechanical properties of PLA/FC films were improved by the inclusion of FC.
33428950	9	56	theme	PLA/FC	1093:1098	arg1	composites					1100:1109	PLA/FC composites	1093:1109	PLA/FC composites	1093:1109	The enhancement in properties for PLA/FC composites could be ascribed to the improved compatibility between PLA and cellulose with the introduction of hydrophobic formate groups.
33428950	7	57	theme	FC	882:883	arg1	addition					870:877	The addition	866:877	The addition of FC	866:883	The addition of FC also resulted in better water barrier properties.
33428950	6	58	contain	containing	748:757	arg1	FC					744:745	1 wt% FC	738:745	1 wt% FC (containing 15.79% formyl groups)	738:779	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	6	58	contain	containing	748:757	arg2	groups					773:778	15.79% formyl groups	759:778	15.79% formyl groups	759:778	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	0	59	theme	enhancement	40:50	arg1	effect					52:57	its enhancement effect	36:57	its enhancement effect on the mechanical and barrier properties of polylactic acid films	36:123	Preparation of formyl cellulose and its enhancement effect on the mechanical and barrier properties of polylactic acid films.
33428950	4	60	theme	rod-like	472:479	arg1	particles					491:499	long rod-like cellulose particles	467:499	long rod-like cellulose particles	467:499	Scanning electron microscopy (SEM) shows that long rod-like cellulose particles were broken into short rods after formylation and the introduction of FC made PLA surface rougher.
33428950	3	61	used	used	345:348	arg2	FC					338:339	FC	338:339	FC	338:339	Then, FC was used to reinforce polylactic acid (PLA) films prepared by solution casting.
33428950	6	62	from	increase	797:804	arg1	strength					817:824	tensile strength	809:824	tensile strength	809:824	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	9	63	from	enhancement	1063:1073	arg1	properties					1078:1087	properties	1078:1087	properties for PLA/FC composites	1078:1109	The enhancement in properties for PLA/FC composites could be ascribed to the improved compatibility between PLA and cellulose with the introduction of hydrophobic formate groups.
33428950	4	64	theme	long	467:470	arg1	particles					491:499	long rod-like cellulose particles	467:499	long rod-like cellulose particles	467:499	Scanning electron microscopy (SEM) shows that long rod-like cellulose particles were broken into short rods after formylation and the introduction of FC made PLA surface rougher.
33428950	10	65	theme	composite	1249:1257	arg1	potential					1304:1312	potential	1304:1312	potential	1304:1312	The PLA/FC composite films developed in this work could be highly potential for food packaging.
33428950	10	65	theme	composite	1249:1257	arg1	films					1259:1263	The PLA/FC composite films	1238:1263	The PLA/FC composite films developed in this work	1238:1286	The PLA/FC composite films developed in this work could be highly potential for food packaging.
33428950	5	66	theme	PLA/FC	629:634	arg1	films					636:640	PLA/FC films	629:640	PLA/FC films	629:640	The mechanical properties of PLA/FC films were improved by the inclusion of FC.
33428950	6	67	theme	%	742:742	arg1	FC					744:745	1 wt% FC	738:745	1 wt% FC (containing 15.79% formyl groups)	738:779	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	2	68	theme	reaction	279:286	arg1	temperature					288:298	reaction temperature	279:298	reaction temperature	279:298	The amount of formyl groups in FC was adjusted by controlling the reaction time, reaction temperature, and formic acid concentration.
33428950	6	69	theme	%	764:764	arg1	groups					773:778	15.79% formyl groups	759:778	15.79% formyl groups	759:778	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	6	70	theme	1 wt	738:741	arg1	FC					744:745	1 wt% FC	738:745	1 wt% FC (containing 15.79% formyl groups)	738:779	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	2	71	theme	groups	219:224	arg1	amount					202:207	The amount	198:207	The amount of formyl groups in FC	198:230	The amount of formyl groups in FC was adjusted by controlling the reaction time, reaction temperature, and formic acid concentration.
33428950	2	71	theme	groups	219:224	arg1	groups					219:224	formyl groups	212:224	formyl groups	212:224	The amount of formyl groups in FC was adjusted by controlling the reaction time, reaction temperature, and formic acid concentration.
33428950	6	72	theme	48.59	790:794	arg1	%					795:795	%	795:795	%	795:795	Compared to pure PLA film, the PLA/FC composite film with 1 wt% FC (containing 15.79% formyl groups) showed a 48.59% increase in tensile strength and a 346% increase in Young's modulus.
33428950	2	73	theme	formyl	212:217	arg1	groups					219:224	formyl groups	212:224	formyl groups	212:224	The amount of formyl groups in FC was adjusted by controlling the reaction time, reaction temperature, and formic acid concentration.
33428950	8	74	theme	absorption	948:957	arg1	capacity					959:966	The moisture absorption capacity	935:966	The moisture absorption capacity	935:966	The moisture absorption capacity and water vapor permeability were 40.56% and 51.43% lower than those of the pure-PLA film.
33428950	8	74	theme	absorption	948:957	arg1	lower					1020:1024	lower	1020:1024	lower	1020:1024	The moisture absorption capacity and water vapor permeability were 40.56% and 51.43% lower than those of the pure-PLA film.
33212367	0	0	theme	chiral	97:102	arg1	phase					115:119	chiral stationary phase	97:119	chiral stationary phase	97:119	Study of enantioseparation of β-blockers using amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions.
33212367	1	1	theme	chromatography	409:422	arg1	conditions					424:433	polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions	344:433	polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase	344:536	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	4	2	theme	buffer	1038:1043	arg1	solutions					1045:1053	sodium hydrogen carbonate-carbonate buffer solutions	1002:1053	sodium hydrogen carbonate-carbonate buffer solutions	1002:1053	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	2	3	theme	mobile	583:588	arg1	phases					590:595	two component mobile phases	569:595	two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture	569:796	Regarding polar-organic mode, two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture were evaluated.
33212367	4	4	theme	carbonate-carbonate	1018:1036	arg1	solutions					1045:1053	sodium hydrogen carbonate-carbonate buffer solutions	1002:1053	sodium hydrogen carbonate-carbonate buffer solutions	1002:1053	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	5	5	theme	retention	1208:1216	arg1	factors					1218:1224	the retention factors	1204:1224	the retention factors of β-blockers enantiomers	1204:1250	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	4	6	with	acetonitrile	941:952	arg1	buffer					992:997	aqueous boric acid-borate buffer	966:997	aqueous boric acid-borate buffer	966:997	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	4	6	with	acetonitrile	941:952	arg1	solutions					1045:1053	sodium hydrogen carbonate-carbonate buffer solutions	1002:1053	sodium hydrogen carbonate-carbonate buffer solutions	1002:1053	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	5	7	contain	containing	1277:1286	arg1	eluents					1269:1275	hydro-organic eluents	1255:1275	hydro-organic eluents containing acetonitrile in presence of diethylamine as additive	1255:1339	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	5	7	contain	containing	1277:1286	arg2	acetonitrile					1288:1299	acetonitrile	1288:1299	acetonitrile in presence of diethylamine	1288:1327	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	3	8	theme	retention	825:833	arg1	Studies					814:820	Studies	814:820	Studies of retention at different temperatures	814:859	Studies of retention at different temperatures were also performed.
33212367	2	9	theme	acid/diethylamine	772:788	arg1	mixture					790:796	trifluoroacetic acid/diethylamine mixture	756:796	trifluoroacetic acid/diethylamine mixture	756:796	Regarding polar-organic mode, two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture were evaluated.
33212367	1	10	theme	β-blockers	313:322	arg1	enantioseparation					285:301	enantioseparation	285:301	enantioseparation of twelve β-blockers	285:322	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	0	11	theme	stationary	104:113	arg1	phase					115:119	chiral stationary phase	97:119	chiral stationary phase	97:119	Study of enantioseparation of β-blockers using amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions.
33212367	2	12	theme	trifluoroacetic	756:770	arg1	mixture					790:796	trifluoroacetic acid/diethylamine mixture	756:796	trifluoroacetic acid/diethylamine mixture	756:796	Regarding polar-organic mode, two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture were evaluated.
33212367	5	13	theme	liquid	1509:1514	arg1	chromatography					1516:1529	hydrophilic interaction liquid chromatography	1485:1529	hydrophilic interaction liquid chromatography	1485:1529	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	4	14	with	methanol	929:936	arg1	buffer					992:997	aqueous boric acid-borate buffer	966:997	aqueous boric acid-borate buffer	966:997	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	4	14	with	methanol	929:936	arg1	solutions					1045:1053	sodium hydrogen carbonate-carbonate buffer solutions	1002:1053	sodium hydrogen carbonate-carbonate buffer solutions	1002:1053	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	0	15	theme	polar-organic	127:139	arg1	conditions					207:216	polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions	127:216	polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions	127:216	Study of enantioseparation of β-blockers using amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions.
33212367	5	16	theme	hydro-organic	1255:1267	arg1	eluents					1269:1275	hydro-organic eluents	1255:1275	hydro-organic eluents containing acetonitrile in presence of diethylamine as additive	1255:1339	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	5	17	theme	chromatography	1516:1529	arg1	interplay					1467:1475	the interplay	1463:1475	the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes	1463:1554	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	5	18	from	evaluation	1190:1199	arg1	eluents					1269:1275	hydro-organic eluents	1255:1275	hydro-organic eluents containing acetonitrile in presence of diethylamine as additive	1255:1339	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	2	19	theme	component	573:581	arg1	phases					590:595	two component mobile phases	569:595	two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture	569:796	Regarding polar-organic mode, two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture were evaluated.
33212367	2	20	theme	polar-organic	549:561	arg1	mode					563:566	polar-organic mode	549:566	polar-organic mode	549:566	Regarding polar-organic mode, two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture were evaluated.
33212367	1	21	theme	immobilized	452:462	arg1	amylose					464:470	immobilized amylose tris(3-chloro-5-methylphenylcarbamate)	452:509	immobilized amylose tris(3-chloro-5-methylphenylcarbamate)	452:509	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	4	22	theme	hydrogen	1009:1016	arg1	solutions					1045:1053	sodium hydrogen carbonate-carbonate buffer solutions	1002:1053	sodium hydrogen carbonate-carbonate buffer solutions	1002:1053	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	5	23	theme	reversed-phase	1535:1548	arg1	modes					1550:1554	reversed-phase modes	1535:1554	reversed-phase modes	1535:1554	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	2	24	theme	additives	672:680	arg1	addition					654:661	the addition	650:661	the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture	650:796	Regarding polar-organic mode, two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture were evaluated.
33212367	4	25	theme	organic	1102:1108	arg1	modifier					1110:1117	organic modifier	1102:1117	organic modifier as well as buffer type and pH	1102:1147	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	4	26	theme	sodium	1002:1007	arg1	solutions					1045:1053	sodium hydrogen carbonate-carbonate buffer solutions	1002:1053	sodium hydrogen carbonate-carbonate buffer solutions	1002:1053	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	0	27	theme	reversed-phase	142:155	arg1	conditions					207:216	polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions	127:216	polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions	127:216	Study of enantioseparation of β-blockers using amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions.
33212367	5	28	theme	systematic	1179:1188	arg1	evaluation					1190:1199	a systematic evaluation	1177:1199	a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive	1177:1339	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	0	29	theme	enantioseparation	9:25	arg1	Study					0:4	Study	0:4	Study of enantioseparation of β-blockers	0:39	Study of enantioseparation of β-blockers using amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions.
33212367	1	30	theme	polar-organic	344:356	arg1	conditions					424:433	polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions	344:433	polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase	344:536	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	3	31	from	Studies	814:820	arg1	temperatures					848:859	different temperatures	838:859	different temperatures	838:859	Studies of retention at different temperatures were also performed.
33212367	4	32	theme	reversed-phase	885:898	arg1	mode					900:903	reversed-phase mode	885:903	reversed-phase mode	885:903	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	5	33	theme	hydrophilic	1485:1495	arg1	chromatography					1516:1529	hydrophilic interaction liquid chromatography	1485:1529	hydrophilic interaction liquid chromatography	1485:1529	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	1	34	from	conditions	424:433	arg1	column					440:445	a column	438:445	a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate)	438:509	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	0	35	theme	hydrophilic	161:171	arg1	chromatography					192:205	hydrophilic interaction liquid chromatography	161:205	hydrophilic interaction liquid chromatography	161:205	Study of enantioseparation of β-blockers using amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions.
33212367	4	36	theme	aqueous	966:972	arg1	buffer					992:997	aqueous boric acid-borate buffer	966:997	aqueous boric acid-borate buffer	966:997	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	5	37	theme	interaction	1497:1507	arg1	chromatography					1516:1529	hydrophilic interaction liquid chromatography	1485:1529	hydrophilic interaction liquid chromatography	1485:1529	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	0	38	theme	β-blockers	30:39	arg1	enantioseparation					9:25	enantioseparation	9:25	enantioseparation of β-blockers	9:39	Study of enantioseparation of β-blockers using amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions.
33212367	1	39	theme	reversed-phase	359:372	arg1	conditions					424:433	polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions	344:433	polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase	344:536	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	4	40	from	influence	1089:1097	arg1	resolution					1152:1161	resolution	1152:1161	resolution	1152:1161	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	5	41	theme	factors	1218:1224	arg1	evaluation					1190:1199	a systematic evaluation	1177:1199	a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive	1177:1339	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	5	42	theme	diethylamine	1316:1327	arg1	presence					1304:1311	presence	1304:1311	presence of diethylamine	1304:1327	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	0	43	theme	liquid	185:190	arg1	chromatography					192:205	hydrophilic interaction liquid chromatography	161:205	hydrophilic interaction liquid chromatography	161:205	Study of enantioseparation of β-blockers using amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions.
33212367	5	44	theme	enantiomers	1240:1250	arg1	factors					1218:1224	the retention factors	1204:1224	the retention factors of β-blockers enantiomers	1204:1250	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	4	45	theme	acid-borate	980:990	arg1	buffer					992:997	aqueous boric acid-borate buffer	966:997	aqueous boric acid-borate buffer	966:997	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	5	46	theme	interplay	1467:1475	arg1	indicative					1449:1458	indicative	1449:1458	indicative	1449:1458	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	1	47	theme	hydrophilic	378:388	arg1	chromatography					409:422	hydrophilic interaction liquid chromatography	378:422	hydrophilic interaction liquid chromatography	378:422	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	0	48	theme	interaction	173:183	arg1	chromatography					192:205	hydrophilic interaction liquid chromatography	161:205	hydrophilic interaction liquid chromatography	161:205	Study of enantioseparation of β-blockers using amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions.
33212367	4	49	theme	boric	974:978	arg1	buffer					992:997	aqueous boric acid-borate buffer	966:997	aqueous boric acid-borate buffer	966:997	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	5	50	theme	β-blockers	1229:1238	arg1	enantiomers					1240:1250	β-blockers enantiomers	1229:1250	β-blockers enantiomers	1229:1250	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	1	51	theme	interaction	390:400	arg1	chromatography					409:422	hydrophilic interaction liquid chromatography	378:422	hydrophilic interaction liquid chromatography	378:422	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	2	52	theme	basic	666:670	arg1	triethylamine					704:716	triethylamine	704:716	triethylamine	704:716	Regarding polar-organic mode, two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture were evaluated.
33212367	2	52	theme	basic	666:670	arg1	mixture					790:796	trifluoroacetic acid/diethylamine mixture	756:796	trifluoroacetic acid/diethylamine mixture	756:796	Regarding polar-organic mode, two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture were evaluated.
33212367	2	52	theme	basic	666:670	arg1	additives					672:680	basic additives	666:680	basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture	666:796	Regarding polar-organic mode, two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture were evaluated.
33212367	2	52	theme	basic	666:670	arg1	mono-ethanolamine					719:735	mono-ethanolamine	719:735	mono-ethanolamine	719:735	Regarding polar-organic mode, two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture were evaluated.
33212367	2	52	theme	basic	666:670	arg1	ethylendiamine					738:751	ethylendiamine	738:751	ethylendiamine	738:751	Regarding polar-organic mode, two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture were evaluated.
33212367	2	52	theme	basic	666:670	arg1	diethylamine					690:701	diethylamine	690:701	diethylamine	690:701	Regarding polar-organic mode, two component mobile phases consisting of methanol, ethanol or acetonitrile with the addition of basic additives such as diethylamine, triethylamine, mono-ethanolamine, ethylendiamine or trifluoroacetic acid/diethylamine mixture were evaluated.
33212367	5	53	theme	water	1389:1393	arg1	content					1395:1401	the water content	1385:1401	the water content	1385:1401	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	1	54	theme	experimental	250:261	arg1	variables					263:271	the experimental variables	246:271	the experimental variables influencing enantioseparation of twelve β-blockers	246:322	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	0	55	theme	chromatography	192:205	arg1	conditions					207:216	polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions	127:216	polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions	127:216	Study of enantioseparation of β-blockers using amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions.
33212367	1	56	theme	chiral	514:519	arg1	phase					532:536	chiral stationary phase	514:536	chiral stationary phase	514:536	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	5	57	theme	modes	1550:1554	arg1	interplay					1467:1475	the interplay	1463:1475	the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes	1463:1554	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	5	58	from	acetonitrile	1288:1299	arg1	presence					1304:1311	presence	1304:1311	presence of diethylamine	1304:1327	In addition, a systematic evaluation of the retention factors of β-blockers enantiomers in hydro-organic eluents containing acetonitrile in presence of diethylamine as additive was carried out by increasing progressively the water content, in order to check for retention dependencies indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes.
33212367	4	59	theme	type	1137:1140	arg1	influence					1089:1097	the influence	1085:1097	the influence of organic modifier as well as buffer type and pH on resolution	1085:1161	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	1	60	theme	stationary	521:530	arg1	phase					532:536	chiral stationary phase	514:536	chiral stationary phase	514:536	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	1	61	with	column	440:445	arg1	amylose					464:470	immobilized amylose tris(3-chloro-5-methylphenylcarbamate)	452:509	immobilized amylose tris(3-chloro-5-methylphenylcarbamate)	452:509	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	1	62	dep	amylose	464:470	arg1	3-chloro-5-methylphenylcarbamate					477:508	3-chloro-5-methylphenylcarbamate	477:508	3-chloro-5-methylphenylcarbamate	477:508	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	1	62	dep	amylose	464:470	arg1	tris					472:475	tris	472:475	immobilized amylose tris(3-chloro-5-methylphenylcarbamate)	452:509	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	4	63	theme	buffer	1130:1135	arg1	type					1137:1140	buffer type	1130:1140	buffer type	1130:1140	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
33212367	1	64	theme	liquid	402:407	arg1	chromatography					409:422	hydrophilic interaction liquid chromatography	378:422	hydrophilic interaction liquid chromatography	378:422	In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase.
33212367	3	65	theme	different	838:846	arg1	temperatures					848:859	different temperatures	838:859	different temperatures	838:859	Studies of retention at different temperatures were also performed.
33212367	3	66	from	temperatures	848:859	arg1	retention					825:833	retention	825:833	retention at different temperatures	825:859	Studies of retention at different temperatures were also performed.
33212367	3	66	from	temperatures	848:859	arg1	Studies					814:820	Studies	814:820	Studies of retention at different temperatures	814:859	Studies of retention at different temperatures were also performed.
33212367	4	67	theme	modifier	1110:1117	arg1	influence					1089:1097	the influence	1085:1097	the influence of organic modifier as well as buffer type and pH on resolution	1085:1161	In reversed-phase mode, mixtures consisting of methanol or acetonitrile with either aqueous boric acid-borate buffer or sodium hydrogen carbonate-carbonate buffer solutions were compared aiming to study the influence of organic modifier as well as buffer type and pH on resolution.
32182480	11	0	theme	better	1480:1485	arg1	selectivity					1490:1500	better N2 selectivity	1480:1500	better N2 selectivity	1480:1500	Fe-Al bimetal @ bent has better N2 selectivity than Fe-Al bimetal.
32182480	1	1	theme	crosslinking	143:154	arg1	Chitosan					122:129	Chitosan	122:129	Chitosan	122:129	Chitosan was used as crosslinking agent to load bimetal particles onto bentonite.
32182480	1	1	theme	crosslinking	143:154	arg1	agent					156:160	crosslinking agent	143:160	crosslinking agent to load bimetal particles onto bentonite	143:201	Chitosan was used as crosslinking agent to load bimetal particles onto bentonite.
32182480	10	2	theme	secondary	1410:1418	arg1	pollution					1420:1428	secondary pollution	1410:1428	secondary pollution	1410:1428	It can effectively improve the reaction rate, pH buffering capacity, reduce secondary pollution and total nitrogen (TN).
32182480	3	3	theme	Dispersive	633:642	arg1	Detector					650:657	Energy Dispersive X-ray Detector	626:657	Energy Dispersive X-ray Detector	626:657	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	8	4	theme	normal	1219:1224	arg1	25 °C					1239:1243	25 °C	1239:1243	25 °C	1239:1243	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	8	4	theme	normal	1219:1224	arg1	temperature					1226:1236	normal temperature	1219:1236	normal temperature (25 °C)	1219:1244	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	3	5	theme	X-ray	644:648	arg1	Detector					650:657	Energy Dispersive X-ray Detector	626:657	Energy Dispersive X-ray Detector	626:657	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	7	6	theme	nitrate	1018:1024	arg1	wastewater					1026:1035	nitrate wastewater	1018:1035	nitrate wastewater	1018:1035	The removal efficiency of nitrate wastewater with a concentration of 50 mg/L was approximately 90% in 60min.
32182480	11	7	theme	Fe-Al	1507:1511	arg1	bimetal					1513:1519	Fe-Al bimetal	1507:1519	Fe-Al bimetal	1507:1519	Fe-Al bimetal @ bent has better N2 selectivity than Fe-Al bimetal.
32182480	3	8	dep	Fourier	448:454	arg1	transform					456:464	transform	456:464	transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX)	456:663	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	9	9	theme	excellent	1304:1312	arg1	effect					1326:1331	excellent synergistic effect	1304:1331	excellent synergistic effect	1304:1331	The reason was that chitosan, bentonite and bimetal have excellent synergistic effect.
32182480	0	10	theme	nitrate	81:87	arg1	removal					70:76	Effective removal	60:76	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.	0:120	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
32182480	7	11	theme	wastewater	1026:1035	arg1	efficiency					1004:1013	The removal efficiency	992:1013	The removal efficiency of nitrate wastewater with a concentration of 50 mg/L	992:1067	The removal efficiency of nitrate wastewater with a concentration of 50 mg/L was approximately 90% in 60min.
32182480	7	11	theme	wastewater	1026:1035	arg1	%					1089:1089	approximately 90%	1073:1089	approximately 90%	1073:1089	The removal efficiency of nitrate wastewater with a concentration of 50 mg/L was approximately 90% in 60min.
32182480	8	12	theme	low	1190:1192	arg1	2-7 °C					1206:1211	2-7 °C	1206:1211	2-7 °C	1206:1211	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	8	12	theme	low	1190:1192	arg1	temperature					1194:1204	low temperature	1190:1204	low temperature(2-7 °C) than normal temperature (25 °C)	1190:1244	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	6	13	theme	removal	898:904	arg1	results					879:885	The experimental results	862:885	The experimental results of nitrate removal	862:904	The experimental results of nitrate removal showed that pH was the main factor affecting on nitrate removal rate and performance.
32182480	10	14	theme	reaction	1365:1372	arg1	rate					1374:1377	the reaction rate	1361:1377	the reaction rate	1361:1377	It can effectively improve the reaction rate, pH buffering capacity, reduce secondary pollution and total nitrogen (TN).
32182480	10	14	theme	reaction	1365:1372	arg1	capacity					1393:1400	pH buffering capacity	1380:1400	pH buffering capacity	1380:1400	It can effectively improve the reaction rate, pH buffering capacity, reduce secondary pollution and total nitrogen (TN).
32182480	8	15	theme	faster	1165:1170	arg1	rate					1182:1185	faster reduction rate	1165:1185	faster reduction rate	1165:1185	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	3	16	theme	X-Ray	496:500	arg1	XRD					515:517	XRD	515:517	XRD	515:517	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	3	16	theme	X-Ray	496:500	arg1	Diffraction					502:512	X-Ray Diffraction	496:512	X-Ray Diffraction (XRD)	496:518	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	2	17	theme	low	361:363	arg1	temperature					365:375	low temperature	361:375	low temperature	361:375	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	3	18	theme	electron	421:428	arg1	SEM					442:444	SEM	442:444	SEM	442:444	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	3	18	theme	electron	421:428	arg1	Fourier					448:454	Fourier	448:454	Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX)	448:663	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	3	18	theme	electron	421:428	arg1	microscope					430:439	Scanning electron microscope	412:439	Scanning electron microscope (SEM)	412:445	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	0	19	theme	by-products	93:103	arg1	removal					70:76	Effective removal	60:76	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.	0:120	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
32182480	7	20	from	%	1089:1089	arg1	60min					1094:1098	60min	1094:1098	60min	1094:1098	The removal efficiency of nitrate wastewater with a concentration of 50 mg/L was approximately 90% in 60min.
32182480	7	21	theme	50 mg/L	1061:1067	arg1	concentration					1044:1056	a concentration	1042:1056	a concentration of 50 mg/L	1042:1067	The removal efficiency of nitrate wastewater with a concentration of 50 mg/L was approximately 90% in 60min.
32182480	1	22	used	used	135:138	arg2	agent					156:160	crosslinking agent	143:160	crosslinking agent to load bimetal particles onto bentonite	143:201	Chitosan was used as crosslinking agent to load bimetal particles onto bentonite.
32182480	1	22	used	used	135:138	arg2	Chitosan					122:129	Chitosan	122:129	Chitosan	122:129	Chitosan was used as crosslinking agent to load bimetal particles onto bentonite.
32182480	1	23	theme	load	165:168	arg1	particles					178:186	load bimetal particles	165:186	load bimetal particles	165:186	Chitosan was used as crosslinking agent to load bimetal particles onto bentonite.
32182480	10	24	dep	improve	1353:1359	arg1	reduce					1403:1408	reduce	1403:1408	reduce secondary pollution and total nitrogen (TN)	1403:1452	It can effectively improve the reaction rate, pH buffering capacity, reduce secondary pollution and total nitrogen (TN).
32182480	2	25	from	wastewater	327:336	arg1	removal					303:309	the efficient removal	289:309	the efficient removal of nitrate from wastewater and its by-products at low temperature	289:375	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	2	26	theme	efficient	293:301	arg1	removal					303:309	the efficient removal	289:309	the efficient removal of nitrate from wastewater and its by-products at low temperature	289:375	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	9	27	contain	have	1299:1302	arg1	bentonite					1277:1285	bentonite	1277:1285	bentonite	1277:1285	The reason was that chitosan, bentonite and bimetal have excellent synergistic effect.
32182480	9	27	contain	have	1299:1302	arg2	effect					1326:1331	excellent synergistic effect	1304:1331	excellent synergistic effect	1304:1331	The reason was that chitosan, bentonite and bimetal have excellent synergistic effect.
32182480	9	27	contain	have	1299:1302	arg1	chitosan					1267:1274	chitosan	1267:1274	chitosan	1267:1274	The reason was that chitosan, bentonite and bimetal have excellent synergistic effect.
32182480	9	27	contain	have	1299:1302	arg1	bimetal					1291:1297	bimetal	1291:1297	bimetal	1291:1297	The reason was that chitosan, bentonite and bimetal have excellent synergistic effect.
32182480	1	28	theme	bimetal	170:176	arg1	particles					178:186	load bimetal particles	165:186	load bimetal particles	165:186	Chitosan was used as crosslinking agent to load bimetal particles onto bentonite.
32182480	6	29	theme	nitrate	890:896	arg1	removal					898:904	nitrate removal	890:904	nitrate removal	890:904	The experimental results of nitrate removal showed that pH was the main factor affecting on nitrate removal rate and performance.
32182480	7	30	theme	removal	996:1002	arg1	efficiency					1004:1013	The removal efficiency	992:1013	The removal efficiency of nitrate wastewater with a concentration of 50 mg/L	992:1067	The removal efficiency of nitrate wastewater with a concentration of 50 mg/L was approximately 90% in 60min.
32182480	7	30	theme	removal	996:1002	arg1	%					1089:1089	approximately 90%	1073:1089	approximately 90%	1073:1089	The removal efficiency of nitrate wastewater with a concentration of 50 mg/L was approximately 90% in 60min.
32182480	2	31	from	by-products	346:356	arg1	removal					303:309	the efficient removal	289:309	the efficient removal of nitrate from wastewater and its by-products at low temperature	289:375	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	5	32	theme	Fe	858:859	arg1	reactivity					844:853	the reactivity	840:853	the reactivity of Fe	840:859	XRD showed that Al can effectively protect the reactivity of Fe.
32182480	3	33	theme	Scanning	412:419	arg1	SEM					442:444	SEM	442:444	SEM	442:444	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	3	33	theme	Scanning	412:419	arg1	Fourier					448:454	Fourier	448:454	Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX)	448:663	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	3	33	theme	Scanning	412:419	arg1	microscope					430:439	Scanning electron microscope	412:439	Scanning electron microscope (SEM)	412:445	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	8	34	theme	bimetal	1107:1113	arg1	bent					1117:1120	Fe-Al bimetal @ bent	1101:1120	Fe-Al bimetal @ bent	1101:1120	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	4	35	theme	aluminum	726:733	arg1	surface					715:721	the surface	711:721	the surface of aluminum	711:733	SEM and EDX showed that Fe0 was deposited on the surface of aluminum, the Fe-Al bimetal were surrounded by chitosan and bentonite.
32182480	10	36	theme	buffering	1383:1391	arg1	rate					1374:1377	the reaction rate	1361:1377	the reaction rate	1361:1377	It can effectively improve the reaction rate, pH buffering capacity, reduce secondary pollution and total nitrogen (TN).
32182480	10	36	theme	buffering	1383:1391	arg1	capacity					1393:1400	pH buffering capacity	1380:1400	pH buffering capacity	1380:1400	It can effectively improve the reaction rate, pH buffering capacity, reduce secondary pollution and total nitrogen (TN).
32182480	3	37	theme	X-ray	537:541	arg1	XPS					571:573	XPS	571:573	XPS	571:573	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	3	37	theme	X-ray	537:541	arg1	spectroscopy					557:568	X-ray photoelectron spectroscopy	537:568	X-ray photoelectron spectroscopy (XPS)	537:574	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	11	38	contain	has	1476:1478	arg2	selectivity					1490:1500	better N2 selectivity	1480:1500	better N2 selectivity	1480:1500	Fe-Al bimetal @ bent has better N2 selectivity than Fe-Al bimetal.
32182480	11	38	contain	has	1476:1478	arg1	bent					1471:1474	Fe-Al bimetal @ bent	1455:1474	Fe-Al bimetal @ bent	1455:1474	Fe-Al bimetal @ bent has better N2 selectivity than Fe-Al bimetal.
32182480	3	39	theme	photoelectron	543:555	arg1	XPS					571:573	XPS	571:573	XPS	571:573	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	3	39	theme	photoelectron	543:555	arg1	spectroscopy					557:568	X-ray photoelectron spectroscopy	537:568	X-ray photoelectron spectroscopy (XPS)	537:574	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	6	40	theme	removal	962:968	arg1	rate					970:973	nitrate removal rate	954:973	nitrate removal rate	954:973	The experimental results of nitrate removal showed that pH was the main factor affecting on nitrate removal rate and performance.
32182480	0	41	theme	chitosan	13:20	arg1	chitosan					13:20	chitosan	13:20	chitosan	13:20	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
32182480	0	41	theme	chitosan	13:20	arg1	Composite					0:8	Composite	0:8	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.	0:120	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
32182480	0	41	theme	chitosan	13:20	arg1	bimetal					51:57	bentonite cladding Fe-Al bimetal	26:57	bentonite cladding Fe-Al bimetal	26:57	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
32182480	10	42	theme	pH	1380:1381	arg1	rate					1374:1377	the reaction rate	1361:1377	the reaction rate	1361:1377	It can effectively improve the reaction rate, pH buffering capacity, reduce secondary pollution and total nitrogen (TN).
32182480	10	42	theme	pH	1380:1381	arg1	capacity					1393:1400	pH buffering capacity	1380:1400	pH buffering capacity	1380:1400	It can effectively improve the reaction rate, pH buffering capacity, reduce secondary pollution and total nitrogen (TN).
32182480	3	43	theme	BET	604:606	arg1	area					617:620	Brunauer-Emmett-Teller (BET) surface area	580:620	Brunauer-Emmett-Teller (BET) surface area	580:620	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	3	43	theme	BET	604:606	arg1	EDX					660:662	EDX	660:662	EDX	660:662	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	9	44	theme	synergistic	1314:1324	arg1	effect					1326:1331	excellent synergistic effect	1304:1331	excellent synergistic effect	1304:1331	The reason was that chitosan, bentonite and bimetal have excellent synergistic effect.
32182480	6	45	theme	nitrate	954:960	arg1	rate					970:973	nitrate removal rate	954:973	nitrate removal rate	954:973	The experimental results of nitrate removal showed that pH was the main factor affecting on nitrate removal rate and performance.
32182480	0	46	theme	cladding	36:43	arg1	bimetal					51:57	bentonite cladding Fe-Al bimetal	26:57	bentonite cladding Fe-Al bimetal	26:57	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
32182480	6	47	theme	experimental	866:877	arg1	results					879:885	The experimental results	862:885	The experimental results of nitrate removal	862:904	The experimental results of nitrate removal showed that pH was the main factor affecting on nitrate removal rate and performance.
32182480	2	48	theme	bentonite	231:239	arg1	complex					264:270	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex	204:270	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex	204:270	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	8	49	theme	Fe-Al	1101:1105	arg1	bent					1117:1120	Fe-Al bimetal @ bent	1101:1120	Fe-Al bimetal @ bent	1101:1120	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	8	50	contain	has	1122:1124	arg1	bent					1117:1120	Fe-Al bimetal @ bent	1101:1120	Fe-Al bimetal @ bent	1101:1120	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	8	50	contain	has	1122:1124	arg2	rate					1182:1185	faster reduction rate	1165:1185	faster reduction rate	1165:1185	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	8	50	contain	has	1122:1124	arg2	performance					1149:1159	better nitrate removal performance	1126:1159	better nitrate removal performance	1126:1159	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	0	51	theme	bentonite	26:34	arg1	bimetal					51:57	bentonite cladding Fe-Al bimetal	26:57	bentonite cladding Fe-Al bimetal	26:57	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
32182480	8	52	theme	@	1115:1115	arg1	bent					1117:1120	Fe-Al bimetal @ bent	1101:1120	Fe-Al bimetal @ bent	1101:1120	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	3	53	theme	Brunauer-Emmett-Teller	580:601	arg1	area					617:620	Brunauer-Emmett-Teller (BET) surface area	580:620	Brunauer-Emmett-Teller (BET) surface area	580:620	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	3	53	theme	Brunauer-Emmett-Teller	580:601	arg1	EDX					660:662	EDX	660:662	EDX	660:662	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	2	54	theme	chitosan	222:229	arg1	bent					258:261	Fe-Al bimetal @ bent	242:261	Fe-Al bimetal @ bent	242:261	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	2	54	theme	chitosan	222:229	arg1	bentonite					231:239	Fe-Al bimetal chitosan bentonite	208:239	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex	204:270	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	11	55	theme	@	1469:1469	arg1	bent					1471:1474	Fe-Al bimetal @ bent	1455:1474	Fe-Al bimetal @ bent	1455:1474	Fe-Al bimetal @ bent has better N2 selectivity than Fe-Al bimetal.
32182480	0	56	theme	bimetal	51:57	arg1	chitosan					13:20	chitosan	13:20	chitosan	13:20	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
32182480	0	56	theme	bimetal	51:57	arg1	Composite					0:8	Composite	0:8	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.	0:120	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
32182480	0	56	theme	bimetal	51:57	arg1	bimetal					51:57	bentonite cladding Fe-Al bimetal	26:57	bentonite cladding Fe-Al bimetal	26:57	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
32182480	4	57	theme	Fe-Al	740:744	arg1	bimetal					746:752	the Fe-Al bimetal	736:752	the Fe-Al bimetal	736:752	SEM and EDX showed that Fe0 was deposited on the surface of aluminum, the Fe-Al bimetal were surrounded by chitosan and bentonite.
32182480	10	58	theme	total	1434:1438	arg1	TN					1450:1451	TN	1450:1451	TN	1450:1451	It can effectively improve the reaction rate, pH buffering capacity, reduce secondary pollution and total nitrogen (TN).
32182480	10	58	theme	total	1434:1438	arg1	nitrogen					1440:1447	total nitrogen	1434:1447	total nitrogen (TN)	1434:1452	It can effectively improve the reaction rate, pH buffering capacity, reduce secondary pollution and total nitrogen (TN).
32182480	2	59	theme	bimetal	214:220	arg1	bent					258:261	Fe-Al bimetal @ bent	242:261	Fe-Al bimetal @ bent	242:261	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	2	59	theme	bimetal	214:220	arg1	bentonite					231:239	Fe-Al bimetal chitosan bentonite	208:239	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex	204:270	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	3	60	theme	infrared	466:473	arg1	FTIR					489:492	FTIR	489:492	FTIR	489:492	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	3	60	theme	infrared	466:473	arg1	spectroscopy					475:486	infrared spectroscopy	466:486	infrared spectroscopy (FTIR)	466:493	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	0	61	theme	Fe-Al	45:49	arg1	bimetal					51:57	bentonite cladding Fe-Al bimetal	26:57	bentonite cladding Fe-Al bimetal	26:57	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
32182480	2	62	theme	Fe-Al	208:212	arg1	bent					258:261	Fe-Al bimetal @ bent	242:261	Fe-Al bimetal @ bent	242:261	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	2	62	theme	Fe-Al	208:212	arg1	bentonite					231:239	Fe-Al bimetal chitosan bentonite	208:239	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex	204:270	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	11	63	theme	Fe-Al	1455:1459	arg1	bent					1471:1474	Fe-Al bimetal @ bent	1455:1474	Fe-Al bimetal @ bent	1455:1474	Fe-Al bimetal @ bent has better N2 selectivity than Fe-Al bimetal.
32182480	2	64	theme	nitrate	314:320	arg1	removal					303:309	the efficient removal	289:309	the efficient removal of nitrate from wastewater and its by-products at low temperature	289:375	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	3	65	theme	Zeta	521:524	arg1	potential					526:534	Zeta potential	521:534	Zeta potential	521:534	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	3	66	theme	Energy	626:631	arg1	Detector					650:657	Energy Dispersive X-ray Detector	626:657	Energy Dispersive X-ray Detector	626:657	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	2	67	theme	@	256:256	arg1	bent					258:261	Fe-Al bimetal @ bent	242:261	Fe-Al bimetal @ bent	242:261	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	2	67	theme	@	256:256	arg1	bentonite					231:239	Fe-Al bimetal chitosan bentonite	208:239	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex	204:270	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	2	68	from	temperature	365:375	arg1	wastewater					327:336	wastewater	327:336	wastewater	327:336	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	2	68	from	temperature	365:375	arg1	by-products					346:356	its by-products	342:356	its by-products at low temperature	342:375	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	7	69	with	efficiency	1004:1013	arg1	concentration					1044:1056	a concentration	1042:1056	a concentration of 50 mg/L	1042:1067	The removal efficiency of nitrate wastewater with a concentration of 50 mg/L was approximately 90% in 60min.
32182480	11	70	theme	bimetal	1461:1467	arg1	bent					1471:1474	Fe-Al bimetal @ bent	1455:1474	Fe-Al bimetal @ bent	1455:1474	Fe-Al bimetal @ bent has better N2 selectivity than Fe-Al bimetal.
32182480	3	71	theme	surface	609:615	arg1	area					617:620	Brunauer-Emmett-Teller (BET) surface area	580:620	Brunauer-Emmett-Teller (BET) surface area	580:620	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	3	71	theme	surface	609:615	arg1	EDX					660:662	EDX	660:662	EDX	660:662	The samples were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Zeta potential, X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller (BET) surface area and Energy Dispersive X-ray Detector (EDX).
32182480	2	72	theme	bimetal	248:254	arg1	bent					258:261	Fe-Al bimetal @ bent	242:261	Fe-Al bimetal @ bent	242:261	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	2	72	theme	bimetal	248:254	arg1	bentonite					231:239	Fe-Al bimetal chitosan bentonite	208:239	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex	204:270	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	11	73	theme	N2	1487:1488	arg1	selectivity					1490:1500	better N2 selectivity	1480:1500	better N2 selectivity	1480:1500	Fe-Al bimetal @ bent has better N2 selectivity than Fe-Al bimetal.
32182480	6	74	theme	main	929:932	arg1	pH					918:919	pH	918:919	pH	918:919	The experimental results of nitrate removal showed that pH was the main factor affecting on nitrate removal rate and performance.
32182480	6	74	theme	main	929:932	arg1	factor					934:939	the main factor	925:939	the main factor affecting on nitrate removal rate and performance	925:989	The experimental results of nitrate removal showed that pH was the main factor affecting on nitrate removal rate and performance.
32182480	0	75	theme	Effective	60:68	arg1	removal					70:76	Effective removal	60:76	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.	0:120	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
32182480	2	76	theme	Fe-Al	242:246	arg1	bent					258:261	Fe-Al bimetal @ bent	242:261	Fe-Al bimetal @ bent	242:261	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	2	76	theme	Fe-Al	242:246	arg1	bentonite					231:239	Fe-Al bimetal chitosan bentonite	208:239	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex	204:270	The Fe-Al bimetal chitosan bentonite (Fe-Al bimetal @ bent) complex was prepared for the efficient removal of nitrate from wastewater and its by-products at low temperature.
32182480	8	77	theme	reduction	1172:1180	arg1	rate					1182:1185	faster reduction rate	1165:1185	faster reduction rate	1165:1185	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	8	78	theme	nitrate	1133:1139	arg1	performance					1149:1159	better nitrate removal performance	1126:1159	better nitrate removal performance	1126:1159	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	8	79	theme	better	1126:1131	arg1	performance					1149:1159	better nitrate removal performance	1126:1159	better nitrate removal performance	1126:1159	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	0	80	dep	Composite	0:8	arg1	removal					70:76	Effective removal	60:76	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.	0:120	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
32182480	8	81	theme	removal	1141:1147	arg1	performance					1149:1159	better nitrate removal performance	1126:1159	better nitrate removal performance	1126:1159	Fe-Al bimetal @ bent has better nitrate removal performance and faster reduction rate at low temperature(2-7 °C) than normal temperature (25 °C).
32182480	0	82	from	wastewater	110:119	arg1	removal					70:76	Effective removal	60:76	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.	0:120	Composite of chitosan and bentonite cladding Fe-Al bimetal: Effective removal of nitrate and by-products from wastewater.
33103477	0	0	theme	Trigonella	90:99	arg1	foenum-graecum					101:114	Egyptian Trigonella foenum-graecum	81:114	Egyptian Trigonella foenum-graecum with insights on its pharmacological activities	81:162	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities.
33103477	0	1	theme	Egyptian	81:88	arg1	foenum-graecum					101:114	Egyptian Trigonella foenum-graecum	81:114	Egyptian Trigonella foenum-graecum with insights on its pharmacological activities	81:162	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities.
33103477	1	2	theme	Trigonella	324:333	arg1	foenum-graecum					335:348	Trigonella foenum-graecum	324:348	Trigonella foenum-graecum	324:348	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	3	3	theme	extraction	639:648	arg1	yield					650:654	the extraction yield	635:654	the extraction yield	635:654	Seven process variables were evaluated (12 experiments in a Plackett-Burman design) to screen the significant factors affecting the extraction yield.
33103477	3	4	theme	process	513:519	arg1	variables					521:529	Seven process variables	507:529	Seven process variables	507:529	Seven process variables were evaluated (12 experiments in a Plackett-Burman design) to screen the significant factors affecting the extraction yield.
33103477	6	5	theme	Candida	1189:1195	arg1	tropicalis					1197:1206	Candida tropicalis	1189:1206	Candida tropicalis	1189:1206	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	0	6	theme	foenum-graecum	101:114	arg1	seeds					72:76	seeds	72:76	seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities	72:162	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities.
33103477	6	7	theme	weak	1118:1121	arg1	activity					1135:1142	weak antioxidant activity	1118:1142	weak antioxidant activity	1118:1142	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	5	8	theme	soaking	906:912	arg1	water					914:918	the soaking water	902:918	the soaking water	902:918	The yield of GAL extraction was influenced by the volume of the precipitating solvent to the volume of the soaking water and reached a maximum of 10.1% at a ratio of 3.633:1.
33103477	1	9	from	optimization	272:283	arg1	foenum-graecum					335:348	Trigonella foenum-graecum	324:348	Trigonella foenum-graecum	324:348	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	6	10	theme	cytotoxic	1001:1009	arg1	activities					1031:1040	the antioxidant, cytotoxic, and anti-microbial activities	984:1040	the antioxidant, cytotoxic, and anti-microbial activities of GAL	984:1047	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	6	11	theme	anti-microbial	1016:1029	arg1	activities					1031:1040	the antioxidant, cytotoxic, and anti-microbial activities	984:1040	the antioxidant, cytotoxic, and anti-microbial activities of GAL	984:1047	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	2	12	theme	pharmacological	392:406	arg1	effects					408:414	pharmacological effects	392:414	pharmacological effects	392:414	GAL was reported to possess a variety of pharmacological effects and is commercialized as adjuvant therapy for diabetes, obesity, and hypercholesterolemia.
33103477	5	13	theme	%	949:949	arg1	maximum					934:940	a maximum	932:940	a maximum of 10.1%	932:949	The yield of GAL extraction was influenced by the volume of the precipitating solvent to the volume of the soaking water and reached a maximum of 10.1% at a ratio of 3.633:1.
33103477	6	14	theme	GAL	1045:1047	arg1	activities					1031:1040	the antioxidant, cytotoxic, and anti-microbial activities	984:1040	the antioxidant, cytotoxic, and anti-microbial activities of GAL	984:1047	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	2	15	theme	adjuvant	441:448	arg1	therapy					450:456	adjuvant therapy	441:456	adjuvant therapy for diabetes, obesity, and hypercholesterolemia	441:504	GAL was reported to possess a variety of pharmacological effects and is commercialized as adjuvant therapy for diabetes, obesity, and hypercholesterolemia.
33103477	6	16	theme	antioxidant	1123:1133	arg1	activity					1135:1142	weak antioxidant activity	1118:1142	weak antioxidant activity	1118:1142	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	5	17	theme	water	914:918	arg1	volume					892:897	the volume	888:897	the volume of the soaking water	888:918	The yield of GAL extraction was influenced by the volume of the precipitating solvent to the volume of the soaking water and reached a maximum of 10.1% at a ratio of 3.633:1.
33103477	4	18	theme	significant	672:682	arg1	variables					684:692	The three most significant variables	657:692	The three most significant variables	657:692	The three most significant variables were evaluated in CCD at two levels (twenty experimental designs) to obtain the utmost percentage yield.
33103477	0	19	theme	Multivariate	0:11	arg1	approach					13:20	Multivariate approach	0:20	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities	0:162	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities.
33103477	3	20	theme	Plackett-Burman	567:581	arg1	design					583:588	a Plackett-Burman design	565:588	a Plackett-Burman design	565:588	Seven process variables were evaluated (12 experiments in a Plackett-Burman design) to screen the significant factors affecting the extraction yield.
33103477	1	21	theme	systemic	263:270	arg1	optimization					272:283	the systemic optimization	259:283	the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum	259:348	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	0	22	theme	pharmacological	137:151	arg1	activities					153:162	its pharmacological activities	133:162	its pharmacological activities	133:162	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities.
33103477	0	23	with	foenum-graecum	101:114	arg1	insights					121:128	insights	121:128	insights on its pharmacological activities	121:162	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities.
33103477	5	24	theme	extraction	816:825	arg1	yield					803:807	The yield	799:807	The yield of GAL extraction	799:825	The yield of GAL extraction was influenced by the volume of the precipitating solvent to the volume of the soaking water and reached a maximum of 10.1% at a ratio of 3.633:1.
33103477	5	25	theme	GAL	812:814	arg1	extraction					816:825	GAL extraction	812:825	GAL extraction	812:825	The yield of GAL extraction was influenced by the volume of the precipitating solvent to the volume of the soaking water and reached a maximum of 10.1% at a ratio of 3.633:1.
33103477	6	26	theme	moderate	1149:1156	arg1	activity					1172:1179	moderate antimicrobial activity	1149:1179	moderate antimicrobial activity	1149:1179	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	4	27	theme	experimental	738:749	arg1	designs					751:757	twenty experimental designs	731:757	twenty experimental designs	731:757	The three most significant variables were evaluated in CCD at two levels (twenty experimental designs) to obtain the utmost percentage yield.
33103477	4	27	theme	experimental	738:749	arg1	levels					723:728	two levels	719:728	two levels (twenty experimental designs)	719:758	The three most significant variables were evaluated in CCD at two levels (twenty experimental designs) to obtain the utmost percentage yield.
33103477	2	28	theme	effects	408:414	arg1	variety					381:387	a variety	379:387	a variety of pharmacological effects	379:414	GAL was reported to possess a variety of pharmacological effects and is commercialized as adjuvant therapy for diabetes, obesity, and hypercholesterolemia.
33103477	2	28	theme	effects	408:414	arg1	effects					408:414	pharmacological effects	392:414	pharmacological effects	392:414	GAL was reported to possess a variety of pharmacological effects and is commercialized as adjuvant therapy for diabetes, obesity, and hypercholesterolemia.
33103477	0	29	theme	galactomannan	42:54	arg1	extraction					56:65	galactomannan extraction	42:65	galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities	42:162	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities.
33103477	6	30	theme	colorectal	1093:1102	arg1	cells					1111:1115	LS174-T colorectal cancer cells	1085:1115	LS174-T colorectal cancer cells	1085:1115	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	1	31	used	used	250:253	arg2	RSM					195:197	RSM	195:197	RSM	195:197	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	1	31	used	used	250:253	arg2	methodology					182:192	Response surface methodology	165:192	Response surface methodology (RSM)	165:198	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	5	32	theme	3.633:1	965:971	arg1	ratio					956:960	a ratio	954:960	a ratio of 3.633:1	954:971	The yield of GAL extraction was influenced by the volume of the precipitating solvent to the volume of the soaking water and reached a maximum of 10.1% at a ratio of 3.633:1.
33103477	1	33	theme	central	214:220	arg1	CCD					240:242	CCD	240:242	CCD	240:242	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	1	33	theme	central	214:220	arg1	design					232:237	the central composite design	210:237	the central composite design (CCD)	210:243	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	1	34	from	foenum-graecum	335:348	arg1	optimization					272:283	the systemic optimization	259:283	the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum	259:348	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	1	34	from	foenum-graecum	335:348	arg1	extraction					308:317	galactomannan (GAL) extraction	288:317	galactomannan (GAL) extraction from Trigonella foenum-graecum	288:348	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	1	35	theme	galactomannan	288:300	arg1	extraction					308:317	galactomannan (GAL) extraction	288:317	galactomannan (GAL) extraction from Trigonella foenum-graecum	288:348	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	6	36	theme	Micrococcus	1212:1222	arg1	species					1224:1230	Micrococcus species	1212:1230	Micrococcus species	1212:1230	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	1	37	theme	composite	222:230	arg1	CCD					240:242	CCD	240:242	CCD	240:242	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	1	37	theme	composite	222:230	arg1	design					232:237	the central composite design	210:237	the central composite design (CCD)	210:243	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	5	38	theme	precipitating	863:875	arg1	solvent					877:883	the precipitating solvent	859:883	the precipitating solvent	859:883	The yield of GAL extraction was influenced by the volume of the precipitating solvent to the volume of the soaking water and reached a maximum of 10.1% at a ratio of 3.633:1.
33103477	6	39	theme	antioxidant	988:998	arg1	activities					1031:1040	the antioxidant, cytotoxic, and anti-microbial activities	984:1040	the antioxidant, cytotoxic, and anti-microbial activities of GAL	984:1047	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	0	40	from	seeds	72:76	arg1	optimization					26:37	optimization	26:37	optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities	26:162	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities.
33103477	0	40	from	seeds	72:76	arg1	extraction					56:65	galactomannan extraction	42:65	galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities	42:162	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities.
33103477	6	41	theme	cancer	1104:1109	arg1	cells					1111:1115	LS174-T colorectal cancer cells	1085:1115	LS174-T colorectal cancer cells	1085:1115	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	0	42	theme	extraction	56:65	arg1	optimization					26:37	optimization	26:37	optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities	26:162	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities.
33103477	1	43	theme	GAL	303:305	arg1	extraction					308:317	galactomannan (GAL) extraction	288:317	galactomannan (GAL) extraction from Trigonella foenum-graecum	288:348	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	0	44	from	optimization	26:37	arg1	seeds					72:76	seeds	72:76	seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities	72:162	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities.
33103477	3	45	dep	evaluated	536:544	arg1	experiments					550:560	12 experiments	547:560	12 experiments in a Plackett-Burman design	547:588	Seven process variables were evaluated (12 experiments in a Plackett-Burman design) to screen the significant factors affecting the extraction yield.
33103477	3	46	from	experiments	550:560	arg1	design					583:588	a Plackett-Burman design	565:588	a Plackett-Burman design	565:588	Seven process variables were evaluated (12 experiments in a Plackett-Burman design) to screen the significant factors affecting the extraction yield.
33103477	6	47	theme	antimicrobial	1158:1170	arg1	activity					1172:1179	moderate antimicrobial activity	1149:1179	moderate antimicrobial activity	1149:1179	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	0	48	from	insights	121:128	arg1	activities					153:162	its pharmacological activities	133:162	its pharmacological activities	133:162	Multivariate approach for optimization of galactomannan extraction from seeds of Egyptian Trigonella foenum-graecum with insights on its pharmacological activities.
33103477	4	49	theme	percentage	781:790	arg1	yield					792:796	the utmost percentage yield	770:796	the utmost percentage yield	770:796	The three most significant variables were evaluated in CCD at two levels (twenty experimental designs) to obtain the utmost percentage yield.
33103477	6	50	theme	LS174-T	1085:1091	arg1	cells					1111:1115	LS174-T colorectal cancer cells	1085:1115	LS174-T colorectal cancer cells	1085:1115	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	4	51	theme	utmost	774:779	arg1	yield					792:796	the utmost percentage yield	770:796	the utmost percentage yield	770:796	The three most significant variables were evaluated in CCD at two levels (twenty experimental designs) to obtain the utmost percentage yield.
33103477	5	52	theme	solvent	877:883	arg1	volume					849:854	the volume	845:854	the volume of the precipitating solvent to the volume of the soaking water	845:918	The yield of GAL extraction was influenced by the volume of the precipitating solvent to the volume of the soaking water and reached a maximum of 10.1% at a ratio of 3.633:1.
33103477	6	53	theme	cytotoxic	1058:1066	arg1	activity					1068:1075	cytotoxic activity	1058:1075	cytotoxic activity against LS174-T colorectal cancer cells	1058:1115	Exploring the antioxidant, cytotoxic, and anti-microbial activities of GAL revealed cytotoxic activity against LS174-T colorectal cancer cells, weak antioxidant activity, and moderate antimicrobial activity against Candida tropicalis and Micrococcus species.
33103477	1	54	theme	Response	165:172	arg1	RSM					195:197	RSM	195:197	RSM	195:197	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	1	54	theme	Response	165:172	arg1	methodology					182:192	Response surface methodology	165:192	Response surface methodology (RSM)	165:198	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	1	55	theme	extraction	308:317	arg1	optimization					272:283	the systemic optimization	259:283	the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum	259:348	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	3	56	theme	significant	605:615	arg1	factors					617:623	the significant factors	601:623	the significant factors affecting the extraction yield	601:654	Seven process variables were evaluated (12 experiments in a Plackett-Burman design) to screen the significant factors affecting the extraction yield.
33103477	1	57	theme	surface	174:180	arg1	RSM					195:197	RSM	195:197	RSM	195:197	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
33103477	1	57	theme	surface	174:180	arg1	methodology					182:192	Response surface methodology	165:192	Response surface methodology (RSM)	165:198	Response surface methodology (RSM), based on the central composite design (CCD), was used for the systemic optimization of galactomannan (GAL) extraction from Trigonella foenum-graecum.
34973726	6	0	theme	cells	889:893	arg1	production					910:919	mucin protein production	896:919	mucin protein production	896:919	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	0	theme	cells	889:893	arg1	extent					969:974	the lower extent	959:974	the lower extent of intestinal fibrosis	959:997	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	0	theme	cells	889:893	arg1	number					872:877	increased number	862:877	increased number of goblet cells	862:893	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	0	theme	cells	889:893	arg1	maintenance					922:932	maintenance	922:932	maintenance	922:932	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	0	1	theme	barrier	78:84	arg1	function					86:93	the intestinal barrier function	63:93	the intestinal barrier function	63:93	Effects of laminarin zwitterionic carboxylate and sulfonate on the intestinal barrier function and gut microbiota.
34973726	6	2	theme	goblet	882:887	arg1	cells					889:893	goblet cells	882:893	goblet cells	882:893	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	3	3	theme	aforementioned	468:481	arg1	zwitterion					494:503	the aforementioned functional zwitterion	464:503	the aforementioned functional zwitterion	464:503	FT-IR and NMR techniques were used to characterize the aforementioned functional zwitterion.
34973726	4	4	theme	UC	518:519	arg1	mice					521:524	UC mice	518:524	UC mice	518:524	Compared to UC mice, the composition and diversity of gut microbiota were significantly increased in the treated mice.
34973726	0	5	theme	gut	99:101	arg1	microbiota					103:112	gut microbiota	99:112	gut microbiota	99:112	Effects of laminarin zwitterionic carboxylate and sulfonate on the intestinal barrier function and gut microbiota.
34973726	0	6	from	Effects	0:6	arg1	function					86:93	the intestinal barrier function	63:93	the intestinal barrier function	63:93	Effects of laminarin zwitterionic carboxylate and sulfonate on the intestinal barrier function and gut microbiota.
34973726	0	6	from	Effects	0:6	arg1	microbiota					103:112	gut microbiota	99:112	gut microbiota	99:112	Effects of laminarin zwitterionic carboxylate and sulfonate on the intestinal barrier function and gut microbiota.
34973726	7	7	theme	promising	1058:1066	arg1	agents					1068:1073	promising agents	1058:1073	promising agents	1058:1073	These findings indicated the potentials of LZC and LZS as promising agents to prevent colitis via adjusting gut microbiota and maintaining intestinal barrier integrity.
34973726	7	7	theme	promising	1058:1066	arg1	potentials					1029:1038	the potentials	1025:1038	the potentials of LZC and LZS	1025:1053	These findings indicated the potentials of LZC and LZS as promising agents to prevent colitis via adjusting gut microbiota and maintaining intestinal barrier integrity.
34973726	2	8	theme	laminarins	283:292	arg1	effectiveness					238:250	the treatment effectiveness	224:250	the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model	224:410	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	4	9	theme	gut	560:562	arg1	microbiota					564:573	gut microbiota	560:573	gut microbiota	560:573	Compared to UC mice, the composition and diversity of gut microbiota were significantly increased in the treated mice.
34973726	4	10	dep	composition	531:541	arg1	the					527:529	the	527:529	the	527:529	Compared to UC mice, the composition and diversity of gut microbiota were significantly increased in the treated mice.
34973726	6	11	theme	protein	902:908	arg1	production					910:919	mucin protein production	896:919	mucin protein production	896:919	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	11	theme	protein	902:908	arg1	number					872:877	increased number	862:877	increased number of goblet cells	862:893	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	2	12	theme	zwitterionic	270:281	arg1	laminarins					283:292	two functional zwitterionic laminarins	255:292	two functional zwitterionic laminarins	255:292	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	2	12	theme	zwitterionic	270:281	arg1	sulfonate					308:316	zwitterionic sulfonate	295:316	zwitterionic sulfonate (LZS)	295:322	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	2	12	theme	zwitterionic	270:281	arg1	carboxylate					341:351	zwitterionic carboxylate	328:351	zwitterionic carboxylate (LZC)	328:357	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	7	13	theme	barrier	1150:1156	arg1	integrity					1158:1166	intestinal barrier integrity	1139:1166	intestinal barrier integrity	1139:1166	These findings indicated the potentials of LZC and LZS as promising agents to prevent colitis via adjusting gut microbiota and maintaining intestinal barrier integrity.
34973726	2	14	theme	zwitterionic	328:339	arg1	laminarins					283:292	two functional zwitterionic laminarins	255:292	two functional zwitterionic laminarins	255:292	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	2	14	theme	zwitterionic	328:339	arg1	LZC					354:356	LZC	354:356	LZC	354:356	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	2	14	theme	zwitterionic	328:339	arg1	carboxylate					341:351	zwitterionic carboxylate	328:351	zwitterionic carboxylate (LZC)	328:357	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	7	15	theme	LZS	1051:1053	arg1	agents					1068:1073	promising agents	1058:1073	promising agents	1058:1073	These findings indicated the potentials of LZC and LZS as promising agents to prevent colitis via adjusting gut microbiota and maintaining intestinal barrier integrity.
34973726	7	15	theme	LZS	1051:1053	arg1	potentials					1029:1038	the potentials	1025:1038	the potentials of LZC and LZS	1025:1053	These findings indicated the potentials of LZC and LZS as promising agents to prevent colitis via adjusting gut microbiota and maintaining intestinal barrier integrity.
34973726	2	16	theme	functional	259:268	arg1	laminarins					283:292	two functional zwitterionic laminarins	255:292	two functional zwitterionic laminarins	255:292	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	2	16	theme	functional	259:268	arg1	sulfonate					308:316	zwitterionic sulfonate	295:316	zwitterionic sulfonate (LZS)	295:322	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	2	16	theme	functional	259:268	arg1	carboxylate					341:351	zwitterionic carboxylate	328:351	zwitterionic carboxylate (LZC)	328:357	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	1	17	theme	global	152:157	arg1	disease					167:173	a global chronic disease	150:173	a global chronic disease that keeps increasing	150:195	Ulcerative colitis (UC) has become a global chronic disease that keeps increasing.
34973726	1	18	theme	chronic	159:165	arg1	disease					167:173	a global chronic disease	150:173	a global chronic disease that keeps increasing	150:195	Ulcerative colitis (UC) has become a global chronic disease that keeps increasing.
34973726	7	19	theme	LZC	1043:1045	arg1	agents					1068:1073	promising agents	1058:1073	promising agents	1058:1073	These findings indicated the potentials of LZC and LZS as promising agents to prevent colitis via adjusting gut microbiota and maintaining intestinal barrier integrity.
34973726	7	19	theme	LZC	1043:1045	arg1	potentials					1029:1038	the potentials	1025:1038	the potentials of LZC and LZS	1025:1053	These findings indicated the potentials of LZC and LZS as promising agents to prevent colitis via adjusting gut microbiota and maintaining intestinal barrier integrity.
34973726	6	20	theme	colitis	766:772	arg1	alleviation					751:761	the alleviation	747:761	the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis	747:997	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	21	theme	increased	862:870	arg1	production					910:919	mucin protein production	896:919	mucin protein production	896:919	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	21	theme	increased	862:870	arg1	number					872:877	increased number	862:877	increased number of goblet cells	862:893	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	21	theme	increased	862:870	arg1	maintenance					922:932	maintenance	922:932	maintenance	922:932	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	7	22	theme	intestinal	1139:1148	arg1	integrity					1158:1166	intestinal barrier integrity	1139:1166	intestinal barrier integrity	1139:1166	These findings indicated the potentials of LZC and LZS as promising agents to prevent colitis via adjusting gut microbiota and maintaining intestinal barrier integrity.
34973726	2	23	theme	mouse	400:404	arg1	model					406:410	dextran sulfate sodium (DSS) induced mouse model	363:410	dextran sulfate sodium (DSS) induced mouse model	363:410	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	6	24	theme	collagens	937:945	arg1	production					910:919	mucin protein production	896:919	mucin protein production	896:919	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	24	theme	collagens	937:945	arg1	extent					969:974	the lower extent	959:974	the lower extent of intestinal fibrosis	959:997	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	24	theme	collagens	937:945	arg1	number					872:877	increased number	862:877	increased number of goblet cells	862:893	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	24	theme	collagens	937:945	arg1	maintenance					922:932	maintenance	922:932	maintenance	922:932	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	2	25	theme	zwitterionic	295:306	arg1	LZS					319:321	LZS	319:321	LZS	319:321	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	2	25	theme	zwitterionic	295:306	arg1	laminarins					283:292	two functional zwitterionic laminarins	255:292	two functional zwitterionic laminarins	255:292	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	2	25	theme	zwitterionic	295:306	arg1	sulfonate					308:316	zwitterionic sulfonate	295:316	zwitterionic sulfonate (LZS)	295:322	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	3	26	theme	NMR	423:425	arg1	techniques					427:436	FT-IR and NMR techniques	413:436	FT-IR and NMR techniques	413:436	FT-IR and NMR techniques were used to characterize the aforementioned functional zwitterion.
34973726	2	27	theme	induced	392:398	arg1	model					406:410	dextran sulfate sodium (DSS) induced mouse model	363:410	dextran sulfate sodium (DSS) induced mouse model	363:410	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	6	28	theme	mucosa	839:844	arg1	integrity					815:823	the improved integrity	802:823	the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis	802:997	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	3	29	used	used	443:446	arg2	techniques					427:436	FT-IR and NMR techniques	413:436	FT-IR and NMR techniques	413:436	FT-IR and NMR techniques were used to characterize the aforementioned functional zwitterion.
34973726	2	30	from	effectiveness	238:250	arg1	model					406:410	dextran sulfate sodium (DSS) induced mouse model	363:410	dextran sulfate sodium (DSS) induced mouse model	363:410	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	3	31	theme	FT-IR	413:417	arg1	techniques					427:436	FT-IR and NMR techniques	413:436	FT-IR and NMR techniques	413:436	FT-IR and NMR techniques were used to characterize the aforementioned functional zwitterion.
34973726	0	32	theme	carboxylate	34:44	arg1	Effects					0:6	Effects	0:6	Effects of laminarin zwitterionic carboxylate and sulfonate on the intestinal barrier function and gut microbiota.	0:113	Effects of laminarin zwitterionic carboxylate and sulfonate on the intestinal barrier function and gut microbiota.
34973726	7	33	theme	gut	1108:1110	arg1	microbiota					1112:1121	gut microbiota	1108:1121	gut microbiota	1108:1121	These findings indicated the potentials of LZC and LZS as promising agents to prevent colitis via adjusting gut microbiota and maintaining intestinal barrier integrity.
34973726	6	34	theme	intestinal	828:837	arg1	mucosa					839:844	intestinal mucosa	828:844	intestinal mucosa	828:844	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	0	35	theme	zwitterionic	21:32	arg1	carboxylate					34:44	laminarin zwitterionic carboxylate	11:44	laminarin zwitterionic carboxylate	11:44	Effects of laminarin zwitterionic carboxylate and sulfonate on the intestinal barrier function and gut microbiota.
34973726	2	36	theme	sodium	379:384	arg1	model					406:410	dextran sulfate sodium (DSS) induced mouse model	363:410	dextran sulfate sodium (DSS) induced mouse model	363:410	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	5	37	theme	Firmicutes	699:708	arg1	level					690:694	the level	686:694	the level of Firmicutes	686:708	Specifically, the composition of Bacteroidetes increased and the level of Firmicutes decreased.
34973726	6	38	theme	fibrosis	990:997	arg1	production					910:919	mucin protein production	896:919	mucin protein production	896:919	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	38	theme	fibrosis	990:997	arg1	extent					969:974	the lower extent	959:974	the lower extent of intestinal fibrosis	959:997	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	38	theme	fibrosis	990:997	arg1	number					872:877	increased number	862:877	increased number of goblet cells	862:893	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	38	theme	fibrosis	990:997	arg1	maintenance					922:932	maintenance	922:932	maintenance	922:932	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	1	39	theme	Ulcerative	115:124	arg1	UC					135:136	UC	135:136	UC	135:136	Ulcerative colitis (UC) has become a global chronic disease that keeps increasing.
34973726	1	39	theme	Ulcerative	115:124	arg1	colitis					126:132	Ulcerative colitis	115:132	Ulcerative colitis (UC)	115:137	Ulcerative colitis (UC) has become a global chronic disease that keeps increasing.
34973726	0	40	theme	sulfonate	50:58	arg1	Effects					0:6	Effects	0:6	Effects of laminarin zwitterionic carboxylate and sulfonate on the intestinal barrier function and gut microbiota.	0:113	Effects of laminarin zwitterionic carboxylate and sulfonate on the intestinal barrier function and gut microbiota.
34973726	2	41	theme	sulfate	371:377	arg1	DSS					387:389	DSS	387:389	DSS	387:389	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	2	41	theme	sulfate	371:377	arg1	sodium					379:384	dextran sulfate sodium	363:384	dextran sulfate sodium (DSS) induced mouse model	363:410	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	6	42	theme	mucin	896:900	arg1	production					910:919	mucin protein production	896:919	mucin protein production	896:919	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	42	theme	mucin	896:900	arg1	number					872:877	increased number	862:877	increased number of goblet cells	862:893	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	5	43	theme	Bacteroidetes	658:670	arg1	composition					643:653	the composition	639:653	the composition of Bacteroidetes	639:670	Specifically, the composition of Bacteroidetes increased and the level of Firmicutes decreased.
34973726	6	44	theme	improved	806:813	arg1	integrity					815:823	the improved integrity	802:823	the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis	802:997	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	6	45	theme	intestinal	979:988	arg1	fibrosis					990:997	intestinal fibrosis	979:997	intestinal fibrosis	979:997	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
34973726	4	46	theme	microbiota	564:573	arg1	diversity					547:555	diversity	547:555	diversity	547:555	Compared to UC mice, the composition and diversity of gut microbiota were significantly increased in the treated mice.
34973726	4	46	theme	microbiota	564:573	arg1	composition					531:541	composition	531:541	composition	531:541	Compared to UC mice, the composition and diversity of gut microbiota were significantly increased in the treated mice.
34973726	0	47	theme	intestinal	67:76	arg1	function					86:93	the intestinal barrier function	63:93	the intestinal barrier function	63:93	Effects of laminarin zwitterionic carboxylate and sulfonate on the intestinal barrier function and gut microbiota.
34973726	4	48	theme	treated	611:617	arg1	mice					619:622	the treated mice	607:622	the treated mice	607:622	Compared to UC mice, the composition and diversity of gut microbiota were significantly increased in the treated mice.
34973726	2	49	theme	treatment	228:236	arg1	effectiveness					238:250	the treatment effectiveness	224:250	the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model	224:410	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	3	50	theme	functional	483:492	arg1	zwitterion					494:503	the aforementioned functional zwitterion	464:503	the aforementioned functional zwitterion	464:503	FT-IR and NMR techniques were used to characterize the aforementioned functional zwitterion.
34973726	2	51	theme	dextran	363:369	arg1	DSS					387:389	DSS	387:389	DSS	387:389	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	2	51	theme	dextran	363:369	arg1	sodium					379:384	dextran sulfate sodium	363:384	dextran sulfate sodium (DSS) induced mouse model	363:410	This study was to explore the treatment effectiveness of two functional zwitterionic laminarins, zwitterionic sulfonate (LZS) and zwitterionic carboxylate (LZC), in dextran sulfate sodium (DSS) induced mouse model.
34973726	0	52	theme	laminarin	11:19	arg1	carboxylate					34:44	laminarin zwitterionic carboxylate	11:44	laminarin zwitterionic carboxylate	11:44	Effects of laminarin zwitterionic carboxylate and sulfonate on the intestinal barrier function and gut microbiota.
34973726	6	53	theme	lower	963:967	arg1	extent					969:974	the lower extent	959:974	the lower extent of intestinal fibrosis	959:997	Moreover, we demonstrated the alleviation of colitis by LZS and LZC reflected by the improved integrity of intestinal mucosa, which includes increased number of goblet cells, mucin protein production, maintenance of collagens, as well as the lower extent of intestinal fibrosis.
32791324	6	0	theme	complex	896:902	arg1	film					904:907	This starch-based complex film	878:907	This starch-based complex film	878:907	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	11	1	theme	CdS/CMS	1791:1797	arg1	selectivity					1776:1786	The selectivity	1772:1786	The selectivity of CdS/CMS	1772:1797	The selectivity of CdS/CMS could not be influenced by pH and some coexisting inorganic anions.
32791324	9	2	theme	anionic	1549:1555	arg1	groups					1557:1562	the anionic groups	1545:1562	the anionic groups on RhB	1545:1569	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	6	3	theme	photocatalysis	1096:1109	arg1	degradation					1111:1121	photocatalysis degradation	1096:1121	photocatalysis degradation	1096:1121	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	4	4	theme	optical	646:652	arg1	property					654:661	optical property	646:661	optical property	646:661	The morphology, composition, and optical property of this film were investigated in detail by various characterization methods.
32791324	1	5	theme	Resource	173:180	arg1	utilization					182:192	Resource utilization	173:192	Resource utilization of wastes through effective separation	173:231	Resource utilization of wastes through effective separation is a major challenge in the field of water and wastewater treatment.
32791324	1	5	theme	Resource	173:180	arg1	challenge					244:252	a major challenge	236:252	a major challenge in the field of water and wastewater treatment	236:299	Resource utilization of wastes through effective separation is a major challenge in the field of water and wastewater treatment.
32791324	12	6	theme	complex	1885:1891	arg1	film					1893:1896	this complex film	1880:1896	this complex film	1880:1896	Furthermore, this complex film did not require regeneration and could be reused directly with low removal capacity loss.
32791324	7	7	from	%	1193:1193	arg1	120 min					1204:1210	120 min	1204:1210	120 min	1204:1210	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	6	8	theme	enrichment	1081:1090	arg1	processes					1057:1065	two consecutive processes	1041:1065	two consecutive processes of adsorption enrichment and photocatalysis degradation	1041:1121	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	1	9	from	challenge	244:252	arg1	field					261:265	the field	257:265	the field of water and wastewater treatment	257:299	Resource utilization of wastes through effective separation is a major challenge in the field of water and wastewater treatment.
32791324	9	10	theme	electrostatic	1578:1590	arg1	repulsion					1592:1600	an electrostatic repulsion	1575:1600	an electrostatic repulsion to the starch matrix	1575:1621	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	7	11	from	CV	1198:1199	arg1	120 min					1204:1210	120 min	1204:1210	120 min	1204:1210	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	6	12	used	used	913:916	arg2	film					904:907	This starch-based complex film	878:907	This starch-based complex film	878:907	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	5	13	located	located	841:847	arg1	region					870:875	the visible light region	852:875	the visible light region	852:875	CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region.
32791324	5	13	located	located	841:847	arg2	wavelength					807:816	the absorption wavelength	792:816	the absorption wavelength of this film	792:829	CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region.
32791324	5	13	located	located	841:847	arg2	located					841:847	located	841:847	located	841:847	CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region.
32791324	10	14	theme	various	1665:1671	arg1	dyes					1673:1676	various dyes	1665:1676	various dyes	1665:1676	The considerably different affinities of various dyes to CMS triggered strong adsorption preferences and great selective degradation effectiveness.
32791324	6	15	theme	various	928:934	arg1	violet					979:984	crystal violet	971:984	crystal violet (CV)	971:989	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	15	theme	various	928:934	arg1	RhB					1009:1011	RhB	1009:1011	RhB	1009:1011	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	15	theme	various	928:934	arg1	[methylene					949:958	[methylene blue	949:963	[methylene blue (MB)	949:968	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	15	theme	various	928:934	arg1	dyes					944:947	various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B	928:1006	various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)]	928:1013	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	15	theme	various	928:934	arg1	B					1006:1006	rhodamine B	996:1006	rhodamine B	996:1006	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	10	16	theme	adsorption	1702:1711	arg1	preferences					1713:1723	strong adsorption preferences	1695:1723	strong adsorption preferences	1695:1723	The considerably different affinities of various dyes to CMS triggered strong adsorption preferences and great selective degradation effectiveness.
32791324	9	17	from	groups	1557:1562	arg1	RhB					1567:1569	RhB	1567:1569	RhB	1567:1569	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	9	18	theme	starch	1609:1614	arg1	matrix					1616:1621	the starch matrix	1605:1621	the starch matrix	1605:1621	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	0	19	theme	CdS	142:144	arg1	film					134:137	a complex film	124:137	a complex film of CdS and carboxylmethyl starch	124:170	A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch.
32791324	12	20	theme	capacity	1973:1980	arg1	loss					1982:1985	low removal capacity loss	1961:1985	low removal capacity loss	1961:1985	Furthermore, this complex film did not require regeneration and could be reused directly with low removal capacity loss.
32791324	13	21	dep	separation	2063:2072	arg1	the					2049:2051	the	2049:2051	the	2049:2051	Therefore, a new and simple strategy was provided to realize the effective separation and recovery of target contaminants in water by photocatalytic degradation technology.
32791324	4	22	theme	various	707:713	arg1	methods					732:738	various characterization methods	707:738	various characterization methods	707:738	The morphology, composition, and optical property of this film were investigated in detail by various characterization methods.
32791324	0	23	theme	carboxylmethyl	150:163	arg1	starch					165:170	carboxylmethyl starch	150:170	carboxylmethyl starch	150:170	A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch.
32791324	10	24	theme	selective	1735:1743	arg1	effectiveness					1757:1769	great selective degradation effectiveness	1729:1769	great selective degradation effectiveness	1729:1769	The considerably different affinities of various dyes to CMS triggered strong adsorption preferences and great selective degradation effectiveness.
32791324	6	25	dep	dyes	944:947	arg1	MB					966:967	MB	966:967	MB	966:967	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	25	dep	dyes	944:947	arg1	CV					987:988	CV	987:988	CV	987:988	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	25	dep	dyes	944:947	arg1	dyes					944:947	various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B	928:1006	various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)]	928:1013	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	25	dep	dyes	944:947	arg1	[methylene					949:958	[methylene blue	949:963	[methylene blue (MB)	949:968	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	25	dep	dyes	944:947	arg1	violet					979:984	crystal violet	971:984	crystal violet (CV)	971:989	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	25	dep	dyes	944:947	arg1	B					1006:1006	rhodamine B	996:1006	rhodamine B	996:1006	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	11	26	theme	coexisting	1838:1847	arg1	anions					1859:1864	some coexisting inorganic anions	1833:1864	some coexisting inorganic anions	1833:1864	The selectivity of CdS/CMS could not be influenced by pH and some coexisting inorganic anions.
32791324	4	27	theme	film	671:674	arg1	composition					629:639	composition	629:639	composition	629:639	The morphology, composition, and optical property of this film were investigated in detail by various characterization methods.
32791324	4	27	theme	film	671:674	arg1	morphology					617:626	morphology	617:626	morphology	617:626	The morphology, composition, and optical property of this film were investigated in detail by various characterization methods.
32791324	4	27	theme	film	671:674	arg1	property					654:661	optical property	646:661	optical property	646:661	The morphology, composition, and optical property of this film were investigated in detail by various characterization methods.
32791324	0	28	theme	organic	62:68	arg1	dyes					70:73	organic dyes	62:73	organic dyes	62:73	A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch.
32791324	5	29	theme	light	864:868	arg1	region					870:875	the visible light region	852:875	the visible light region	852:875	CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region.
32791324	8	30	theme	selective	1247:1255	arg1	degradation					1272:1282	evidently selective photocatalysis degradation	1237:1282	evidently selective photocatalysis degradation of MB and CV	1237:1295	CdS/CMS still exhibited evidently selective photocatalysis degradation of MB and CV in MB/RhB and CV/RhB binary systems, respectively, and had nearly no effect on RhB.
32791324	5	31	from	region	870:875	arg1	located					841:847	located	841:847	located	841:847	CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region.
32791324	5	31	from	region	870:875	arg1	wavelength					807:816	the absorption wavelength	792:816	the absorption wavelength of this film	792:829	CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region.
32791324	0	32	theme	adsorption	93:102	arg1	enrichment					104:113	selective adsorption enrichment	83:113	selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch	83:170	A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch.
32791324	6	33	theme	blue	960:963	arg1	MB					966:967	MB	966:967	MB	966:967	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	33	theme	blue	960:963	arg1	dyes					944:947	various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B	928:1006	various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)]	928:1013	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	33	theme	blue	960:963	arg1	[methylene					949:958	[methylene blue	949:963	[methylene blue (MB)	949:968	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	2	34	theme	contaminants	430:441	arg1	degradation					396:406	degradation	396:406	degradation of various coexisting contaminants due to its strong oxidation	396:469	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	8	35	theme	MB	1287:1288	arg1	degradation					1272:1282	evidently selective photocatalysis degradation	1237:1282	evidently selective photocatalysis degradation of MB and CV	1237:1295	CdS/CMS still exhibited evidently selective photocatalysis degradation of MB and CV in MB/RhB and CV/RhB binary systems, respectively, and had nearly no effect on RhB.
32791324	2	36	contain	has	374:376	arg2	selectivity					381:391	no selectivity	378:391	no selectivity in degradation of various coexisting contaminants due to its strong oxidation	378:469	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	2	36	contain	has	374:376	arg1	degradation					317:327	Photocatalytic degradation	302:327	Photocatalytic degradation	302:327	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	2	36	contain	has	374:376	arg1	technology					359:368	a powerful water treatment technology	332:368	a powerful water treatment technology	332:368	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	9	37	theme	carboxyl	1455:1462	arg1	CMS					1474:1476	CMS	1474:1476	CMS	1474:1476	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	9	37	theme	carboxyl	1455:1462	arg1	groups					1464:1469	negatively carboxyl groups	1444:1469	negatively carboxyl groups of CMS	1444:1476	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	8	38	theme	CV	1294:1295	arg1	degradation					1272:1282	evidently selective photocatalysis degradation	1237:1282	evidently selective photocatalysis degradation of MB and CV	1237:1295	CdS/CMS still exhibited evidently selective photocatalysis degradation of MB and CV in MB/RhB and CV/RhB binary systems, respectively, and had nearly no effect on RhB.
32791324	1	39	theme	water	270:274	arg1	field					261:265	the field	257:265	the field of water and wastewater treatment	257:299	Resource utilization of wastes through effective separation is a major challenge in the field of water and wastewater treatment.
32791324	6	40	theme	rhodamine	996:1004	arg1	B					1006:1006	rhodamine B	996:1006	rhodamine B	996:1006	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	40	theme	rhodamine	996:1004	arg1	dyes					944:947	various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B	928:1006	various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)]	928:1013	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	10	41	theme	great	1729:1733	arg1	effectiveness					1757:1769	great selective degradation effectiveness	1729:1769	great selective degradation effectiveness	1729:1769	The considerably different affinities of various dyes to CMS triggered strong adsorption preferences and great selective degradation effectiveness.
32791324	2	42	theme	due	443:445	arg1	contaminants					430:441	various coexisting contaminants	411:441	various coexisting contaminants due to its strong oxidation	411:469	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	1	43	theme	wastewater	280:289	arg1	treatment					291:299	wastewater treatment	280:299	wastewater treatment	280:299	Resource utilization of wastes through effective separation is a major challenge in the field of water and wastewater treatment.
32791324	12	44	theme	low	1961:1963	arg1	loss					1982:1985	low removal capacity loss	1961:1985	low removal capacity loss	1961:1985	Furthermore, this complex film did not require regeneration and could be reused directly with low removal capacity loss.
32791324	7	45	theme	MB	1181:1182	arg1	MB					1181:1182	MB	1181:1182	MB	1181:1182	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	7	45	theme	MB	1181:1182	arg1	%					1193:1193	81.03%	1188:1193	81.03% of CV in 120 min	1188:1210	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	7	45	theme	MB	1181:1182	arg1	%					1176:1176	approximately 86.72%	1157:1176	approximately 86.72% of MB	1157:1182	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	7	45	theme	MB	1181:1182	arg1	CV					1198:1199	CV	1198:1199	CV in 120 min	1198:1210	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	2	46	theme	coexisting	419:428	arg1	contaminants					430:441	various coexisting contaminants	411:441	various coexisting contaminants due to its strong oxidation	411:469	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	0	47	theme	selective	22:30	arg1	degradation					47:57	selective photocatalysis degradation	22:57	selective photocatalysis degradation of organic dyes	22:73	A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch.
32791324	13	48	theme	contaminants	2097:2108	arg1	recovery					2078:2085	recovery	2078:2085	recovery	2078:2085	Therefore, a new and simple strategy was provided to realize the effective separation and recovery of target contaminants in water by photocatalytic degradation technology.
32791324	13	48	theme	contaminants	2097:2108	arg1	separation					2063:2072	effective separation	2053:2072	effective separation	2053:2072	Therefore, a new and simple strategy was provided to realize the effective separation and recovery of target contaminants in water by photocatalytic degradation technology.
32791324	5	49	theme	starch	773:778	arg1	matrix					780:785	the starch matrix	769:785	the starch matrix	769:785	CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region.
32791324	3	50	theme	complex	488:494	arg1	film					496:499	a complex film	486:499	a complex film composed of CdS and carboxylmethyl starch (CdS/CMS)	486:551	In this work, a complex film composed of CdS and carboxylmethyl starch (CdS/CMS) was designed and fabricated using in situ formation method.
32791324	4	51	dep	morphology	617:626	arg1	The					613:615	The	613:615	The	613:615	The morphology, composition, and optical property of this film were investigated in detail by various characterization methods.
32791324	7	52	theme	CV	1198:1199	arg1	MB					1181:1182	MB	1181:1182	MB	1181:1182	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	7	52	theme	CV	1198:1199	arg1	%					1193:1193	81.03%	1188:1193	81.03% of CV in 120 min	1188:1210	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	7	52	theme	CV	1198:1199	arg1	%					1176:1176	approximately 86.72%	1157:1176	approximately 86.72% of MB	1157:1182	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	7	52	theme	CV	1198:1199	arg1	CV					1198:1199	CV	1198:1199	CV in 120 min	1198:1210	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	2	53	theme	powerful	334:341	arg1	degradation					317:327	Photocatalytic degradation	302:327	Photocatalytic degradation	302:327	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	2	53	theme	powerful	334:341	arg1	technology					359:368	a powerful water treatment technology	332:368	a powerful water treatment technology	332:368	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	9	54	theme	good	1524:1527	arg1	affinities					1529:1538	their good affinities	1518:1538	their good affinities	1518:1538	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	1	55	theme	major	238:242	arg1	utilization					182:192	Resource utilization	173:192	Resource utilization of wastes through effective separation	173:231	Resource utilization of wastes through effective separation is a major challenge in the field of water and wastewater treatment.
32791324	1	55	theme	major	238:242	arg1	challenge					244:252	a major challenge	236:252	a major challenge in the field of water and wastewater treatment	236:299	Resource utilization of wastes through effective separation is a major challenge in the field of water and wastewater treatment.
32791324	6	56	theme	starch-based	883:894	arg1	film					904:907	This starch-based complex film	878:907	This starch-based complex film	878:907	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	7	57	from	%	1176:1176	arg1	120 min					1204:1210	120 min	1204:1210	120 min	1204:1210	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	8	58	contain	had	1352:1354	arg1	CdS/CMS					1213:1219	CdS/CMS	1213:1219	CdS/CMS	1213:1219	CdS/CMS still exhibited evidently selective photocatalysis degradation of MB and CV in MB/RhB and CV/RhB binary systems, respectively, and had nearly no effect on RhB.
32791324	8	58	contain	had	1352:1354	arg2	effect					1366:1371	nearly no effect	1356:1371	nearly no effect	1356:1371	CdS/CMS still exhibited evidently selective photocatalysis degradation of MB and CV in MB/RhB and CV/RhB binary systems, respectively, and had nearly no effect on RhB.
32791324	13	59	theme	effective	2053:2061	arg1	separation					2063:2072	effective separation	2053:2072	effective separation	2053:2072	Therefore, a new and simple strategy was provided to realize the effective separation and recovery of target contaminants in water by photocatalytic degradation technology.
32791324	2	60	from	selectivity	381:391	arg1	degradation					396:406	degradation	396:406	degradation of various coexisting contaminants due to its strong oxidation	396:469	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	6	61	theme	degradation	1111:1121	arg1	processes					1057:1065	two consecutive processes	1041:1065	two consecutive processes of adsorption enrichment and photocatalysis degradation	1041:1121	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	2	62	theme	treatment	349:357	arg1	degradation					317:327	Photocatalytic degradation	302:327	Photocatalytic degradation	302:327	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	2	62	theme	treatment	349:357	arg1	technology					359:368	a powerful water treatment technology	332:368	a powerful water treatment technology	332:368	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	10	63	theme	different	1641:1649	arg1	affinities					1651:1660	The considerably different affinities	1624:1660	The considerably different affinities of various dyes to CMS	1624:1683	The considerably different affinities of various dyes to CMS triggered strong adsorption preferences and great selective degradation effectiveness.
32791324	8	64	dep	MB/RhB	1300:1305	arg1	systems					1325:1331	binary systems	1318:1331	binary systems	1318:1331	CdS/CMS still exhibited evidently selective photocatalysis degradation of MB and CV in MB/RhB and CV/RhB binary systems, respectively, and had nearly no effect on RhB.
32791324	3	65	dep	in	587:588	arg1	situ					590:593	situ	590:593	situ	590:593	In this work, a complex film composed of CdS and carboxylmethyl starch (CdS/CMS) was designed and fabricated using in situ formation method.
32791324	6	66	theme	adsorption	1070:1079	arg1	enrichment					1081:1090	adsorption enrichment	1070:1090	adsorption enrichment	1070:1090	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	0	67	theme	complex	126:132	arg1	film					134:137	a complex film	124:137	a complex film of CdS and carboxylmethyl starch	124:170	A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch.
32791324	2	68	theme	Photocatalytic	302:315	arg1	degradation					317:327	Photocatalytic degradation	302:327	Photocatalytic degradation	302:327	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	2	68	theme	Photocatalytic	302:315	arg1	technology					359:368	a powerful water treatment technology	332:368	a powerful water treatment technology	332:368	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	1	69	theme	wastes	197:202	arg1	utilization					182:192	Resource utilization	173:192	Resource utilization of wastes through effective separation	173:231	Resource utilization of wastes through effective separation is a major challenge in the field of water and wastewater treatment.
32791324	1	69	theme	wastes	197:202	arg1	challenge					244:252	a major challenge	236:252	a major challenge in the field of water and wastewater treatment	236:299	Resource utilization of wastes through effective separation is a major challenge in the field of water and wastewater treatment.
32791324	6	70	theme	organic	936:942	arg1	violet					979:984	crystal violet	971:984	crystal violet (CV)	971:989	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	70	theme	organic	936:942	arg1	RhB					1009:1011	RhB	1009:1011	RhB	1009:1011	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	70	theme	organic	936:942	arg1	[methylene					949:958	[methylene blue	949:963	[methylene blue (MB)	949:968	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	70	theme	organic	936:942	arg1	dyes					944:947	various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B	928:1006	various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)]	928:1013	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	70	theme	organic	936:942	arg1	B					1006:1006	rhodamine B	996:1006	rhodamine B	996:1006	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	3	71	theme	in	587:588	arg1	method					605:610	in situ formation method	587:610	in situ formation method	587:610	In this work, a complex film composed of CdS and carboxylmethyl starch (CdS/CMS) was designed and fabricated using in situ formation method.
32791324	5	72	theme	film	826:829	arg1	located					841:847	located	841:847	located	841:847	CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region.
32791324	5	72	theme	film	826:829	arg1	wavelength					807:816	the absorption wavelength	792:816	the absorption wavelength of this film	792:829	CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region.
32791324	10	73	theme	strong	1695:1700	arg1	preferences					1713:1723	strong adsorption preferences	1695:1723	strong adsorption preferences	1695:1723	The considerably different affinities of various dyes to CMS triggered strong adsorption preferences and great selective degradation effectiveness.
32791324	9	74	theme	cationic	1385:1392	arg1	groups					1394:1399	The cationic groups	1381:1399	The cationic groups on MB and CV	1381:1412	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	9	75	from	groups	1394:1399	arg1	CV					1411:1412	CV	1411:1412	CV	1411:1412	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	9	75	from	groups	1394:1399	arg1	MB					1404:1405	MB	1404:1405	MB	1404:1405	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	0	76	theme	starch	165:170	arg1	film					134:137	a complex film	124:137	a complex film of CdS and carboxylmethyl starch	124:170	A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch.
32791324	13	77	theme	new	2001:2003	arg1	strategy					2016:2023	a new and simple strategy	1999:2023	a new and simple strategy	1999:2023	Therefore, a new and simple strategy was provided to realize the effective separation and recovery of target contaminants in water by photocatalytic degradation technology.
32791324	10	78	theme	degradation	1745:1755	arg1	effectiveness					1757:1769	great selective degradation effectiveness	1729:1769	great selective degradation effectiveness	1729:1769	The considerably different affinities of various dyes to CMS triggered strong adsorption preferences and great selective degradation effectiveness.
32791324	10	79	theme	dyes	1673:1676	arg1	affinities					1651:1660	The considerably different affinities	1624:1660	The considerably different affinities of various dyes to CMS	1624:1683	The considerably different affinities of various dyes to CMS triggered strong adsorption preferences and great selective degradation effectiveness.
32791324	0	80	theme	dyes	70:73	arg1	degradation					47:57	selective photocatalysis degradation	22:57	selective photocatalysis degradation of organic dyes	22:73	A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch.
32791324	13	81	theme	simple	2009:2014	arg1	strategy					2016:2023	a new and simple strategy	1999:2023	a new and simple strategy	1999:2023	Therefore, a new and simple strategy was provided to realize the effective separation and recovery of target contaminants in water by photocatalytic degradation technology.
32791324	3	82	theme	formation	595:603	arg1	method					605:610	in situ formation method	587:610	in situ formation method	587:610	In this work, a complex film composed of CdS and carboxylmethyl starch (CdS/CMS) was designed and fabricated using in situ formation method.
32791324	5	83	theme	visible	856:862	arg1	region					870:875	the visible light region	852:875	the visible light region	852:875	CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region.
32791324	6	84	theme	crystal	971:977	arg1	dyes					944:947	various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B	928:1006	various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)]	928:1013	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	84	theme	crystal	971:977	arg1	CV					987:988	CV	987:988	CV	987:988	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	6	84	theme	crystal	971:977	arg1	violet					979:984	crystal violet	971:984	crystal violet (CV)	971:989	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	11	85	theme	inorganic	1849:1857	arg1	anions					1859:1864	some coexisting inorganic anions	1833:1864	some coexisting inorganic anions	1833:1864	The selectivity of CdS/CMS could not be influenced by pH and some coexisting inorganic anions.
32791324	7	86	theme	film	1141:1144	arg1	0.1 g					1124:1128	0.1 g	1124:1128	0.1 g of CdS/CMS film	1124:1144	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	0	87	theme	selective	83:91	arg1	enrichment					104:113	selective adsorption enrichment	83:113	selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch	83:170	A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch.
32791324	5	88	from	located	841:847	arg1	region					870:875	the visible light region	852:875	the visible light region	852:875	CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region.
32791324	13	89	theme	photocatalytic	2122:2135	arg1	technology					2149:2158	photocatalytic degradation technology	2122:2158	photocatalytic degradation technology	2122:2158	Therefore, a new and simple strategy was provided to realize the effective separation and recovery of target contaminants in water by photocatalytic degradation technology.
32791324	12	90	theme	removal	1965:1971	arg1	loss					1982:1985	low removal capacity loss	1961:1985	low removal capacity loss	1961:1985	Furthermore, this complex film did not require regeneration and could be reused directly with low removal capacity loss.
32791324	7	91	theme	CdS/CMS	1133:1139	arg1	film					1141:1144	CdS/CMS film	1133:1144	CdS/CMS film	1133:1144	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	8	92	theme	photocatalysis	1257:1270	arg1	degradation					1272:1282	evidently selective photocatalysis degradation	1237:1282	evidently selective photocatalysis degradation of MB and CV	1237:1295	CdS/CMS still exhibited evidently selective photocatalysis degradation of MB and CV in MB/RhB and CV/RhB binary systems, respectively, and had nearly no effect on RhB.
32791324	0	93	theme	simple	2:7	arg1	strategy					9:16	A simple strategy	0:16	A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch.	0:171	A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch.
32791324	2	94	theme	strong	454:459	arg1	oxidation					461:469	its strong oxidation	450:469	its strong oxidation	450:469	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	4	95	theme	characterization	715:730	arg1	methods					732:738	various characterization methods	707:738	various characterization methods	707:738	The morphology, composition, and optical property of this film were investigated in detail by various characterization methods.
32791324	5	96	theme	absorption	796:805	arg1	located					841:847	located	841:847	located	841:847	CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region.
32791324	5	96	theme	absorption	796:805	arg1	wavelength					807:816	the absorption wavelength	792:816	the absorption wavelength of this film	792:829	CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region.
32791324	13	97	theme	degradation	2137:2147	arg1	technology					2149:2158	photocatalytic degradation technology	2122:2158	photocatalytic degradation technology	2122:2158	Therefore, a new and simple strategy was provided to realize the effective separation and recovery of target contaminants in water by photocatalytic degradation technology.
32791324	9	98	theme	CMS	1474:1476	arg1	CMS					1474:1476	CMS	1474:1476	CMS	1474:1476	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	9	98	theme	CMS	1474:1476	arg1	groups					1464:1469	negatively carboxyl groups	1444:1469	negatively carboxyl groups of CMS	1444:1476	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	13	99	from	separation	2063:2072	arg1	water					2113:2117	water	2113:2117	water	2113:2117	Therefore, a new and simple strategy was provided to realize the effective separation and recovery of target contaminants in water by photocatalytic degradation technology.
32791324	9	100	contain	had	1571:1573	arg1	groups					1557:1562	the anionic groups	1545:1562	the anionic groups on RhB	1545:1569	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	9	100	contain	had	1571:1573	arg2	repulsion					1592:1600	an electrostatic repulsion	1575:1600	an electrostatic repulsion to the starch matrix	1575:1621	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	0	101	theme	photocatalysis	32:45	arg1	degradation					47:57	selective photocatalysis degradation	22:57	selective photocatalysis degradation of organic dyes	22:73	A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch.
32791324	1	102	theme	treatment	291:299	arg1	field					261:265	the field	257:265	the field of water and wastewater treatment	257:299	Resource utilization of wastes through effective separation is a major challenge in the field of water and wastewater treatment.
32791324	1	103	theme	effective	212:220	arg1	separation					222:231	effective separation	212:231	effective separation	212:231	Resource utilization of wastes through effective separation is a major challenge in the field of water and wastewater treatment.
32791324	9	104	theme	electrostatic	1482:1494	arg1	interactions					1496:1507	electrostatic interactions	1482:1507	electrostatic interactions	1482:1507	The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix.
32791324	2	105	theme	various	411:417	arg1	contaminants					430:441	various coexisting contaminants	411:441	various coexisting contaminants due to its strong oxidation	411:469	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	7	106	from	120 min	1204:1210	arg1	MB					1181:1182	MB	1181:1182	MB	1181:1182	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	7	106	from	120 min	1204:1210	arg1	%					1193:1193	81.03%	1188:1193	81.03% of CV in 120 min	1188:1210	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	7	106	from	120 min	1204:1210	arg1	%					1176:1176	approximately 86.72%	1157:1176	approximately 86.72% of MB	1157:1182	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	7	106	from	120 min	1204:1210	arg1	CV					1198:1199	CV	1198:1199	CV in 120 min	1198:1210	0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min.
32791324	6	107	theme	consecutive	1045:1055	arg1	processes					1057:1065	two consecutive processes	1041:1065	two consecutive processes of adsorption enrichment and photocatalysis degradation	1041:1121	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	8	108	theme	binary	1318:1323	arg1	systems					1325:1331	binary systems	1318:1331	binary systems	1318:1331	CdS/CMS still exhibited evidently selective photocatalysis degradation of MB and CV in MB/RhB and CV/RhB binary systems, respectively, and had nearly no effect on RhB.
32791324	2	109	theme	water	343:347	arg1	degradation					317:327	Photocatalytic degradation	302:327	Photocatalytic degradation	302:327	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	2	109	theme	water	343:347	arg1	technology					359:368	a powerful water treatment technology	332:368	a powerful water treatment technology	332:368	Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation.
32791324	13	110	from	recovery	2078:2085	arg1	water					2113:2117	water	2113:2117	water	2113:2117	Therefore, a new and simple strategy was provided to realize the effective separation and recovery of target contaminants in water by photocatalytic degradation technology.
32791324	6	111	theme	aqueous	1020:1026	arg1	solutions					1028:1036	aqueous solutions	1020:1036	aqueous solutions	1020:1036	This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation.
32791324	13	112	theme	target	2090:2095	arg1	contaminants					2097:2108	target contaminants	2090:2108	target contaminants	2090:2108	Therefore, a new and simple strategy was provided to realize the effective separation and recovery of target contaminants in water by photocatalytic degradation technology.
33047204	9	0	used	used	1549:1552	arg2	combination					1498:1508	The combination	1494:1508	The combination of nHAp particles with chitosan	1494:1540	CLINICAL RELEVANCE The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.
33047204	9	1	theme	nHAp	1513:1516	arg1	particles					1518:1526	nHAp particles	1513:1526	nHAp particles	1513:1526	CLINICAL RELEVANCE The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.
33047204	1	2	theme	physical	236:243	arg1	properties					261:270	the morphological, chemical, physical, and biological properties	207:270	the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers	207:305	OBJECTIVES This study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers.
33047204	7	3	theme	P.	1280:1281	arg1	gingivalis					1283:1292	P. gingivalis biofilm	1280:1300	P. gingivalis biofilm	1280:1300	Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm.
33047204	7	4	theme	antibacterial	1159:1171	arg1	potential					1173:1181	greater antibacterial potential	1151:1181	greater antibacterial potential against most tested bacteria (except for P. intermedia)	1151:1237	Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm.
33047204	7	5	theme	higher	1244:1249	arg1	activity					1263:1270	higher antibiofilm activity	1244:1270	higher antibiofilm activity against P. gingivalis biofilm	1244:1300	Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm.
33047204	6	6	dep	distribution	1004:1015	arg1	compared					1020:1027	compared	1020:1027	compared to the control fibers	1020:1049	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	3	7	theme	chitosan	538:545	arg1	nHAp-free					555:563	nHAp-free	555:563	nHAp-free	555:563	Neat chitosan fibers (nHAp-free, Ch fibers) were used as the control.
33047204	3	7	theme	chitosan	538:545	arg1	fibers					547:552	Neat chitosan fibers	533:552	Neat chitosan fibers (nHAp-free, Ch fibers)	533:575	Neat chitosan fibers (nHAp-free, Ch fibers) were used as the control.
33047204	3	7	theme	chitosan	538:545	arg1	control					594:600	the control	590:600	the control	590:600	Neat chitosan fibers (nHAp-free, Ch fibers) were used as the control.
33047204	9	8	dep	RELEVANCE	1484:1492	arg1	used					1549:1552	used	1549:1552	can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry	1542:1662	CLINICAL RELEVANCE The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.
33047204	9	9	theme	composite	1589:1597	arg1	nanofibers					1599:1608	bioactive, electrospun composite nanofibers	1566:1608	bioactive, electrospun composite nanofibers	1566:1608	CLINICAL RELEVANCE The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.
33047204	2	10	dep	MATERIALS	308:316	arg1	particles					335:343	nHAp particles	330:343	nHAp particles	330:343	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	7	11	dep	gingivalis	1283:1292	arg1	biofilm					1294:1300	biofilm	1294:1300	P. gingivalis biofilm	1280:1300	Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm.
33047204	6	12	theme	bead-like	921:929	arg1	morphology					931:940	a bead-like morphology	919:940	a bead-like morphology	919:940	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	8	13	theme	nHAp	1336:1339	arg1	particles					1341:1349	nHAp particles	1336:1349	nHAp particles	1336:1349	CONCLUSIONS The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers.
33047204	7	14	theme	tested	1196:1201	arg1	bacteria					1203:1210	most tested bacteria	1191:1210	most tested bacteria (except for P. intermedia)	1191:1237	Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm.
33047204	0	15	theme	physical	53:60	arg1	properties					78:87	the morphological, physical, and biological properties	34:87	the morphological, physical, and biological properties of chitosan	34:99	The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers.
33047204	1	16	from	effects	157:163	arg1	properties					261:270	the morphological, chemical, physical, and biological properties	207:270	the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers	207:305	OBJECTIVES This study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers.
33047204	9	17	theme	bioactive	1566:1574	arg1	nanofibers					1599:1608	bioactive, electrospun composite nanofibers	1566:1608	bioactive, electrospun composite nanofibers	1566:1608	CLINICAL RELEVANCE The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.
33047204	9	18	theme	regenerative	1641:1652	arg1	dentistry					1654:1662	regenerative dentistry	1641:1662	regenerative dentistry	1641:1662	CLINICAL RELEVANCE The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.
33047204	7	19	theme	similar	1068:1074	arg1	viability					1081:1089	similar cell viability	1068:1089	similar cell viability	1068:1089	Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm.
33047204	6	20	theme	ChHa	894:897	arg1	fibers					899:904	ChHa fibers	894:904	ChHa fibers	894:904	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	2	21	theme	nHAp-loaded	499:509	arg1	fibers					511:516	nHAp-loaded fibers	499:516	nHAp-loaded fibers (ChHa fibers)	499:530	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	2	21	theme	nHAp-loaded	499:509	arg1	fibers					524:529	ChHa fibers	519:529	ChHa fibers	519:529	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	8	22	theme	overall	1374:1380	arg1	morphology					1382:1391	the overall morphology	1370:1391	the overall morphology	1370:1391	CONCLUSIONS The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers.
33047204	8	22	theme	overall	1374:1380	arg1	topography					1394:1403	topography	1394:1403	topography	1394:1403	CONCLUSIONS The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers.
33047204	8	22	theme	overall	1374:1380	arg1	characteristics					1431:1445	physical, and biological characteristics	1406:1445	physical, and biological characteristics of the chitosan nanofibers	1406:1472	CONCLUSIONS The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers.
33047204	7	23	theme	greater	1151:1157	arg1	potential					1173:1181	greater antibacterial potential	1151:1181	greater antibacterial potential against most tested bacteria (except for P. intermedia)	1151:1237	Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm.
33047204	0	24	theme	chitosan	92:99	arg1	properties					78:87	the morphological, physical, and biological properties	34:87	the morphological, physical, and biological properties of chitosan	34:99	The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers.
33047204	2	25	theme	chitosan	441:448	arg1	solution					458:465	chitosan polymer solution	441:465	chitosan polymer solution (0.5 wt%)	441:475	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	2	25	theme	chitosan	441:448	arg1	%					474:474	0.5 wt%	468:474	0.5 wt%	468:474	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	1	26	theme	biological	250:259	arg1	properties					261:270	the morphological, chemical, physical, and biological properties	207:270	the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers	207:305	OBJECTIVES This study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers.
33047204	3	27	used	used	582:585	arg2	fibers					547:552	Neat chitosan fibers	533:552	Neat chitosan fibers (nHAp-free, Ch fibers)	533:575	Neat chitosan fibers (nHAp-free, Ch fibers) were used as the control.
33047204	3	27	used	used	582:585	arg2	control					594:600	the control	590:600	the control	590:600	Neat chitosan fibers (nHAp-free, Ch fibers) were used as the control.
33047204	3	27	used	used	582:585	arg2	nHAp-free					555:563	nHAp-free	555:563	nHAp-free	555:563	Neat chitosan fibers (nHAp-free, Ch fibers) were used as the control.
33047204	2	28	with	METHODS	322:328	arg1	ratio					362:366	a 1.67 Ca/P ratio	350:366	a 1.67 Ca/P ratio	350:366	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	6	29	theme	thinner	948:954	arg1	distribution					1004:1015	thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution	948:1015	thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers	948:1049	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	2	30	theme	aqueous	393:399	arg1	method					415:420	the aqueous precipitation method	389:420	the aqueous precipitation method	389:420	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	1	31	theme	electrospun	284:294	arg1	nanofibers					296:305	chitosan electrospun nanofibers	275:305	chitosan electrospun nanofibers	275:305	OBJECTIVES This study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers.
33047204	8	32	theme	biological	1420:1429	arg1	characteristics					1431:1445	physical, and biological characteristics	1406:1445	physical, and biological characteristics of the chitosan nanofibers	1406:1472	CONCLUSIONS The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers.
33047204	8	32	theme	biological	1420:1429	arg1	morphology					1382:1391	the overall morphology	1370:1391	the overall morphology	1370:1391	CONCLUSIONS The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers.
33047204	4	33	dep	[ALP	800:803	arg1	phosphatase					788:798	alkaline phosphatase	779:798	alkaline phosphatase	779:798	The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses.
33047204	4	33	dep	[ALP	800:803	arg1	antibiofilm					746:756	antibiofilm	746:756	antibiofilm	746:756	The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses.
33047204	4	33	dep	[ALP	800:803	arg1	viability					764:772	cell viability	759:772	cell viability	759:772	The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses.
33047204	9	34	theme	CLINICAL	1475:1482	arg1	RELEVANCE					1484:1492	CLINICAL RELEVANCE	1475:1492	CLINICAL RELEVANCE The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.	1475:1663	CLINICAL RELEVANCE The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.
33047204	6	35	theme	2.9	990:992	arg1	±					994:994	±	994:994	±	994:994	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	6	36	dep	=	988:988	arg1	μm					1000:1001	2.9 ± 0.3 μm	990:1001	2.9 ± 0.3 μm	990:1001	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	9	37	from	applications	1625:1636	arg1	dentistry					1654:1662	regenerative dentistry	1641:1662	regenerative dentistry	1641:1662	CLINICAL RELEVANCE The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.
33047204	8	38	theme	chitosan	1454:1461	arg1	nanofibers					1463:1472	the chitosan nanofibers	1450:1472	the chitosan nanofibers	1450:1472	CONCLUSIONS The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers.
33047204	9	39	with	combination	1498:1508	arg1	chitosan					1533:1540	chitosan	1533:1540	chitosan	1533:1540	CLINICAL RELEVANCE The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.
33047204	6	40	dep	thinner	948:954	arg1	nm					967:968	331 ± 110 nm	957:968	331 ± 110 nm	957:968	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	2	41	theme	Ca/P	357:360	arg1	ratio					362:366	a 1.67 Ca/P ratio	350:366	a 1.67 Ca/P ratio	350:366	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	6	42	theme	smoother	975:982	arg1	distribution					1004:1015	thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution	948:1015	thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers	948:1049	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	8	43	dep	CONCLUSIONS	1303:1313	arg1	incorporation					1319:1331	The incorporation	1315:1331	CONCLUSIONS The incorporation of nHAp particles	1303:1349	CONCLUSIONS The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers.
33047204	9	44	theme	particles	1518:1526	arg1	combination					1498:1508	The combination	1494:1508	The combination of nHAp particles with chitosan	1494:1540	CLINICAL RELEVANCE The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.
33047204	7	45	theme	ALP	1095:1097	arg1	activity					1099:1106	ALP activity	1095:1106	ALP activity	1095:1106	Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm.
33047204	4	46	theme	activity	806:813	arg1	range					710:714	a range	708:714	a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses	708:823	The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses.
33047204	1	47	theme	nanohydroxyapatite	168:185	arg1	particles					194:202	nanohydroxyapatite (nHAp) particles	168:202	nanohydroxyapatite (nHAp) particles	168:202	OBJECTIVES This study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers.
33047204	0	48	theme	morphological	38:50	arg1	properties					78:87	the morphological, physical, and biological properties	34:87	the morphological, physical, and biological properties of chitosan	34:99	The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers.
33047204	9	49	dep	bioactive	1566:1574	arg1	electrospun					1577:1587	electrospun	1577:1587	electrospun	1577:1587	CLINICAL RELEVANCE The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.
33047204	3	50	theme	Neat	533:536	arg1	nHAp-free					555:563	nHAp-free	555:563	nHAp-free	555:563	Neat chitosan fibers (nHAp-free, Ch fibers) were used as the control.
33047204	3	50	theme	Neat	533:536	arg1	fibers					547:552	Neat chitosan fibers	533:552	Neat chitosan fibers (nHAp-free, Ch fibers)	533:575	Neat chitosan fibers (nHAp-free, Ch fibers) were used as the control.
33047204	3	50	theme	Neat	533:536	arg1	control					594:600	the control	590:600	the control	590:600	Neat chitosan fibers (nHAp-free, Ch fibers) were used as the control.
33047204	3	51	dep	nHAp-free	555:563	arg1	fibers					569:574	Ch fibers	566:574	Ch fibers	566:574	Neat chitosan fibers (nHAp-free, Ch fibers) were used as the control.
33047204	4	52	theme	alkaline	779:786	arg1	phosphatase					788:798	alkaline phosphatase	779:798	alkaline phosphatase	779:798	The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses.
33047204	7	53	theme	antibiofilm	1251:1261	arg1	activity					1263:1270	higher antibiofilm activity	1244:1270	higher antibiofilm activity against P. gingivalis biofilm	1244:1300	Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm.
33047204	4	54	theme	electrospun	607:617	arg1	mats					625:628	The electrospun fiber mats	603:628	The electrospun fiber mats	603:628	The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses.
33047204	4	55	theme	cell	759:762	arg1	viability					764:772	cell viability	759:772	cell viability	759:772	The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses.
33047204	1	56	theme	nHAp	188:191	arg1	particles					194:202	nanohydroxyapatite (nHAp) particles	168:202	nanohydroxyapatite (nHAp) particles	168:202	OBJECTIVES This study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers.
33047204	2	57	theme	ChHa	519:522	arg1	fibers					511:516	nHAp-loaded fibers	499:516	nHAp-loaded fibers (ChHa fibers)	499:530	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	2	57	theme	ChHa	519:522	arg1	fibers					524:529	ChHa fibers	519:529	ChHa fibers	519:529	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	6	58	theme	0.3	996:998	arg1	±					994:994	±	994:994	±	994:994	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	1	59	theme	particles	194:202	arg1	effects					157:163	the effects	153:163	the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers	153:305	OBJECTIVES This study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers.
33047204	4	60	theme	fiber	619:623	arg1	mats					625:628	The electrospun fiber mats	603:628	The electrospun fiber mats	603:628	The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses.
33047204	9	61	theme	potential	1615:1623	arg1	applications					1625:1636	potential applications	1615:1636	potential applications in regenerative dentistry	1615:1662	CLINICAL RELEVANCE The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.
33047204	8	62	theme	particles	1341:1349	arg1	incorporation					1319:1331	The incorporation	1315:1331	CONCLUSIONS The incorporation of nHAp particles	1303:1349	CONCLUSIONS The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers.
33047204	6	63	theme	=	988:988	arg1	Ra					985:986	Ra	985:986	Ra = 2.9 ± 0.3 μm	985:1001	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	7	64	theme	cell	1076:1079	arg1	viability					1081:1089	similar cell viability	1068:1089	similar cell viability	1068:1089	Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm.
33047204	3	65	theme	Ch	566:567	arg1	fibers					569:574	Ch fibers	566:574	Ch fibers	566:574	Neat chitosan fibers (nHAp-free, Ch fibers) were used as the control.
33047204	6	66	dep	RESULTS	886:892	arg1	demonstrated					906:917	demonstrated	906:917	demonstrated	906:917	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	6	67	theme	control	1036:1042	arg1	fibers					1044:1049	the control fibers	1032:1049	the control fibers	1032:1049	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	0	68	theme	biological	67:76	arg1	properties					78:87	the morphological, physical, and biological properties	34:87	the morphological, physical, and biological properties of chitosan	34:99	The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers.
33047204	2	69	theme	wt	472:473	arg1	solution					458:465	chitosan polymer solution	441:465	chitosan polymer solution (0.5 wt%)	441:475	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	2	69	theme	wt	472:473	arg1	%					474:474	0.5 wt%	468:474	0.5 wt%	468:474	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	0	70	from	role	4:7	arg1	properties					78:87	the morphological, physical, and biological properties	34:87	the morphological, physical, and biological properties of chitosan	34:99	The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers.
33047204	2	71	with	MATERIALS	308:316	arg1	ratio					362:366	a 1.67 Ca/P ratio	350:366	a 1.67 Ca/P ratio	350:366	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	1	72	dep	OBJECTIVES	113:122	arg1	aimed					135:139	aimed	135:139	aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers	135:305	OBJECTIVES This study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers.
33047204	6	73	theme	±	961:961	arg1	nm					967:968	331 ± 110 nm	957:968	331 ± 110 nm	957:968	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	8	74	theme	physical	1406:1413	arg1	characteristics					1431:1445	physical, and biological characteristics	1406:1445	physical, and biological characteristics of the chitosan nanofibers	1406:1472	CONCLUSIONS The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers.
33047204	8	74	theme	physical	1406:1413	arg1	morphology					1382:1391	the overall morphology	1370:1391	the overall morphology	1370:1391	CONCLUSIONS The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers.
33047204	0	75	theme	nanohydroxyapatite	12:29	arg1	role					4:7	The role	0:7	The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan	0:99	The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers.
33047204	2	76	theme	precipitation	401:413	arg1	method					415:420	the aqueous precipitation method	389:420	the aqueous precipitation method	389:420	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	1	77	theme	chitosan	275:282	arg1	nanofibers					296:305	chitosan electrospun nanofibers	275:305	chitosan electrospun nanofibers	275:305	OBJECTIVES This study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers.
33047204	7	78	theme	ChHa	1126:1129	arg1	fibers					1131:1136	the ChHa fibers	1122:1136	the ChHa fibers	1122:1136	Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm.
33047204	1	79	theme	nanofibers	296:305	arg1	properties					261:270	the morphological, chemical, physical, and biological properties	207:270	the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers	207:305	OBJECTIVES This study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers.
33047204	2	80	theme	polymer	450:456	arg1	solution					458:465	chitosan polymer solution	441:465	chitosan polymer solution (0.5 wt%)	441:475	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	2	80	theme	polymer	450:456	arg1	%					474:474	0.5 wt%	468:474	0.5 wt%	468:474	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	6	81	dep	smoother	975:982	arg1	Ra					985:986	Ra	985:986	Ra = 2.9 ± 0.3 μm	985:1001	RESULTS ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers.
33047204	2	82	theme	nHAp	330:333	arg1	particles					335:343	nHAp particles	330:343	nHAp particles	330:343	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	2	83	dep	synthesized	373:383	arg1	incorporated					423:434	incorporated	423:434	incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers)	423:530	MATERIALS AND METHODS nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers).
33047204	7	84	theme	Ch	1111:1112	arg1	fibers					1114:1119	Ch fibers	1111:1119	Ch fibers	1111:1119	Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm.
33047204	8	85	theme	nanofibers	1463:1472	arg1	characteristics					1431:1445	physical, and biological characteristics	1406:1445	physical, and biological characteristics of the chitosan nanofibers	1406:1472	CONCLUSIONS The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers.
33047204	8	85	theme	nanofibers	1463:1472	arg1	morphology					1382:1391	the overall morphology	1370:1391	the overall morphology	1370:1391	CONCLUSIONS The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers.
33047204	4	86	theme	range	710:714	arg1	analyses					816:823	a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses	708:823	a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses	708:823	The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses.
33047204	4	87	theme	biological	719:728	arg1	activity					806:813	biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity	719:813	biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity	719:813	The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses.
33047204	4	87	theme	biological	719:728	arg1	[ALP					800:803	antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP	731:803	[ALP	800:803	The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses.
33047204	1	88	theme	morphological	211:223	arg1	properties					261:270	the morphological, chemical, physical, and biological properties	207:270	the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers	207:305	OBJECTIVES This study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers.
33047204	4	89	theme	antibacterial	731:743	arg1	activity					806:813	biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity	719:813	biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity	719:813	The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses.
33047204	4	89	theme	antibacterial	731:743	arg1	[ALP					800:803	antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP	731:803	[ALP	800:803	The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses.
33047204	1	90	theme	chemical	226:233	arg1	properties					261:270	the morphological, chemical, physical, and biological properties	207:270	the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers	207:305	OBJECTIVES This study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers.
35006859	0	0	theme	Seed	107:110	arg1	Extract					112:118	Alizarin and Grapefruit Seed Extract	83:118	Extract	112:118	Fabrication of Carboxymethyl Cellulose/Agar-Based Functional Films Hybridized with Alizarin and Grapefruit Seed Extract.
35006859	5	1	theme	GSE	642:644	arg1	addition					617:624	the addition	613:624	the addition of alizarin and GSE	613:644	Also, the addition of alizarin and GSE slightly improved the water vapor barrier properties but did not affect the thermal stability of the film.
35006859	0	2	theme	Grapefruit	96:105	arg1	Extract					112:118	Alizarin and Grapefruit Seed Extract	83:118	Extract	112:118	Fabrication of Carboxymethyl Cellulose/Agar-Based Functional Films Hybridized with Alizarin and Grapefruit Seed Extract.
35006859	7	3	theme	detection	967:975	arg1	function					977:984	a volatile gas detection function	952:984	a volatile gas detection function	952:984	The composite film showed an excellent pH-dependent color change with color reversibility and color stability and a volatile gas detection function.
35006859	7	4	theme	excellent	867:875	arg1	change					896:901	an excellent pH-dependent color change	864:901	an excellent pH-dependent color change with color reversibility and color stability	864:946	The composite film showed an excellent pH-dependent color change with color reversibility and color stability and a volatile gas detection function.
35006859	8	5	theme	foodborne	1046:1054	arg1	bacteria					1067:1074	foodborne pathogenic bacteria	1046:1074	foodborne pathogenic bacteria	1046:1074	The film also showed potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes, and showed an intense antioxidant action.
35006859	8	5	theme	foodborne	1046:1054	arg1	coli					1089:1092	Escherichia coli	1077:1092	Escherichia coli	1077:1092	The film also showed potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes, and showed an intense antioxidant action.
35006859	8	5	theme	foodborne	1046:1054	arg1	monocytogenes					1107:1119	Listeria monocytogenes	1098:1119	Listeria monocytogenes	1098:1119	The film also showed potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes, and showed an intense antioxidant action.
35006859	7	6	with	change	896:901	arg1	reversibility					914:926	color reversibility	908:926	color reversibility	908:926	The composite film showed an excellent pH-dependent color change with color reversibility and color stability and a volatile gas detection function.
35006859	7	6	with	change	896:901	arg1	stability					938:946	color stability	932:946	color stability	932:946	The composite film showed an excellent pH-dependent color change with color reversibility and color stability and a volatile gas detection function.
35006859	7	7	theme	volatile	954:961	arg1	function					977:984	a volatile gas detection function	952:984	a volatile gas detection function	952:984	The composite film showed an excellent pH-dependent color change with color reversibility and color stability and a volatile gas detection function.
35006859	2	8	theme	compatible	319:328	arg1	films					340:344	compatible composite films	319:344	compatible composite films	319:344	The fillers were evenly dispersed in the polymer matrix to form compatible composite films.
35006859	2	9	theme	composite	330:338	arg1	films					340:344	compatible composite films	319:344	compatible composite films	319:344	The fillers were evenly dispersed in the polymer matrix to form compatible composite films.
35006859	5	10	theme	thermal	722:728	arg1	stability					730:738	the thermal stability	718:738	the thermal stability of the film	718:750	Also, the addition of alizarin and GSE slightly improved the water vapor barrier properties but did not affect the thermal stability of the film.
35006859	8	11	theme	pathogenic	1056:1065	arg1	bacteria					1067:1074	foodborne pathogenic bacteria	1046:1074	foodborne pathogenic bacteria	1046:1074	The film also showed potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes, and showed an intense antioxidant action.
35006859	8	11	theme	pathogenic	1056:1065	arg1	coli					1089:1092	Escherichia coli	1077:1092	Escherichia coli	1077:1092	The film also showed potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes, and showed an intense antioxidant action.
35006859	8	11	theme	pathogenic	1056:1065	arg1	monocytogenes					1107:1119	Listeria monocytogenes	1098:1119	Listeria monocytogenes	1098:1119	The film also showed potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes, and showed an intense antioxidant action.
35006859	6	12	theme	blocking	790:797	arg1	properties					799:808	UV blocking properties	787:808	UV blocking properties	787:808	The composite film also exhibited UV blocking properties with adequate transparency.
35006859	3	13	theme	color	487:491	arg1	properties					504:513	excellent color indicating properties	477:513	excellent color indicating properties	477:513	The addition of alizarin has improved the film's mechanical strength (20%) and water resistance (40%) with potent antioxidant and excellent color indicating properties.
35006859	6	14	theme	UV	787:788	arg1	properties					799:808	UV blocking properties	787:808	UV blocking properties	787:808	The composite film also exhibited UV blocking properties with adequate transparency.
35006859	8	15	theme	potent	1008:1013	arg1	activity					1029:1036	potent antimicrobial activity	1008:1036	potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes	1008:1119	The film also showed potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes, and showed an intense antioxidant action.
35006859	7	16	theme	composite	842:850	arg1	film					852:855	The composite film	838:855	The composite film	838:855	The composite film showed an excellent pH-dependent color change with color reversibility and color stability and a volatile gas detection function.
35006859	1	17	theme	grapefruit	224:233	arg1	GSE					249:251	GSE	249:251	GSE	249:251	Carboxymethyl cellulose/agar-based functional halochromic films were fabricated by adding alizarin and grapefruit seed extract (GSE).
35006859	1	17	theme	grapefruit	224:233	arg1	extract					240:246	grapefruit seed extract	224:246	grapefruit seed extract (GSE)	224:252	Carboxymethyl cellulose/agar-based functional halochromic films were fabricated by adding alizarin and grapefruit seed extract (GSE).
35006859	5	18	theme	alizarin	629:636	arg1	addition					617:624	the addition	613:624	the addition of alizarin and GSE	613:644	Also, the addition of alizarin and GSE slightly improved the water vapor barrier properties but did not affect the thermal stability of the film.
35006859	1	19	theme	seed	235:238	arg1	GSE					249:251	GSE	249:251	GSE	249:251	Carboxymethyl cellulose/agar-based functional halochromic films were fabricated by adding alizarin and grapefruit seed extract (GSE).
35006859	1	19	theme	seed	235:238	arg1	extract					240:246	grapefruit seed extract	224:246	grapefruit seed extract (GSE)	224:252	Carboxymethyl cellulose/agar-based functional halochromic films were fabricated by adding alizarin and grapefruit seed extract (GSE).
35006859	4	20	theme	antibacterial	553:565	arg1	activities					583:592	strong antibacterial and antioxidant activities	546:592	strong antibacterial and antioxidant activities	546:592	In contrast, GSE has imparted strong antibacterial and antioxidant activities to the film.
35006859	7	21	theme	color	932:936	arg1	stability					938:946	color stability	932:946	color stability	932:946	The composite film showed an excellent pH-dependent color change with color reversibility and color stability and a volatile gas detection function.
35006859	3	22	theme	mechanical	396:405	arg1	strength					407:414	the film's mechanical strength	385:414	the film's mechanical strength (20%)	385:420	The addition of alizarin has improved the film's mechanical strength (20%) and water resistance (40%) with potent antioxidant and excellent color indicating properties.
35006859	3	22	theme	mechanical	396:405	arg1	%					419:419	20%	417:419	20%	417:419	The addition of alizarin has improved the film's mechanical strength (20%) and water resistance (40%) with potent antioxidant and excellent color indicating properties.
35006859	4	23	theme	strong	546:551	arg1	activities					583:592	strong antibacterial and antioxidant activities	546:592	strong antibacterial and antioxidant activities	546:592	In contrast, GSE has imparted strong antibacterial and antioxidant activities to the film.
35006859	6	24	theme	composite	757:765	arg1	film					767:770	The composite film	753:770	The composite film	753:770	The composite film also exhibited UV blocking properties with adequate transparency.
35006859	1	25	theme	Carboxymethyl	121:133	arg1	films					179:183	Carboxymethyl cellulose/agar-based functional halochromic films	121:183	Carboxymethyl cellulose/agar-based functional halochromic films	121:183	Carboxymethyl cellulose/agar-based functional halochromic films were fabricated by adding alizarin and grapefruit seed extract (GSE).
35006859	8	26	theme	antimicrobial	1015:1027	arg1	activity					1029:1036	potent antimicrobial activity	1008:1036	potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes	1008:1119	The film also showed potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes, and showed an intense antioxidant action.
35006859	3	27	theme	potent	454:459	arg1	antioxidant					461:471	potent antioxidant	454:471	potent antioxidant	454:471	The addition of alizarin has improved the film's mechanical strength (20%) and water resistance (40%) with potent antioxidant and excellent color indicating properties.
35006859	0	28	theme	Carboxymethyl	15:27	arg1	Films					61:65	Carboxymethyl Cellulose/Agar-Based Functional Films	15:65	Carboxymethyl Cellulose/Agar-Based Functional Films	15:65	Fabrication of Carboxymethyl Cellulose/Agar-Based Functional Films Hybridized with Alizarin and Grapefruit Seed Extract.
35006859	4	29	theme	antioxidant	571:581	arg1	activities					583:592	strong antibacterial and antioxidant activities	546:592	strong antibacterial and antioxidant activities	546:592	In contrast, GSE has imparted strong antibacterial and antioxidant activities to the film.
35006859	8	30	theme	Listeria	1098:1105	arg1	bacteria					1067:1074	foodborne pathogenic bacteria	1046:1074	foodborne pathogenic bacteria	1046:1074	The film also showed potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes, and showed an intense antioxidant action.
35006859	8	30	theme	Listeria	1098:1105	arg1	monocytogenes					1107:1119	Listeria monocytogenes	1098:1119	Listeria monocytogenes	1098:1119	The film also showed potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes, and showed an intense antioxidant action.
35006859	1	31	theme	cellulose/agar-based	135:154	arg1	films					179:183	Carboxymethyl cellulose/agar-based functional halochromic films	121:183	Carboxymethyl cellulose/agar-based functional halochromic films	121:183	Carboxymethyl cellulose/agar-based functional halochromic films were fabricated by adding alizarin and grapefruit seed extract (GSE).
35006859	7	32	theme	gas	963:965	arg1	function					977:984	a volatile gas detection function	952:984	a volatile gas detection function	952:984	The composite film showed an excellent pH-dependent color change with color reversibility and color stability and a volatile gas detection function.
35006859	0	33	theme	Films	61:65	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of Carboxymethyl Cellulose/Agar-Based Functional Films	0:65	Fabrication of Carboxymethyl Cellulose/Agar-Based Functional Films Hybridized with Alizarin and Grapefruit Seed Extract.
35006859	3	34	theme	indicating	493:502	arg1	properties					504:513	excellent color indicating properties	477:513	excellent color indicating properties	477:513	The addition of alizarin has improved the film's mechanical strength (20%) and water resistance (40%) with potent antioxidant and excellent color indicating properties.
35006859	0	35	theme	Functional	50:59	arg1	Films					61:65	Carboxymethyl Cellulose/Agar-Based Functional Films	15:65	Carboxymethyl Cellulose/Agar-Based Functional Films	15:65	Fabrication of Carboxymethyl Cellulose/Agar-Based Functional Films Hybridized with Alizarin and Grapefruit Seed Extract.
35006859	3	36	theme	water	426:430	arg1	resistance					432:441	water resistance	426:441	water resistance (40%)	426:447	The addition of alizarin has improved the film's mechanical strength (20%) and water resistance (40%) with potent antioxidant and excellent color indicating properties.
35006859	3	36	theme	water	426:430	arg1	%					446:446	40%	444:446	40%	444:446	The addition of alizarin has improved the film's mechanical strength (20%) and water resistance (40%) with potent antioxidant and excellent color indicating properties.
35006859	0	37	theme	Cellulose/Agar-Based	29:48	arg1	Films					61:65	Carboxymethyl Cellulose/Agar-Based Functional Films	15:65	Carboxymethyl Cellulose/Agar-Based Functional Films	15:65	Fabrication of Carboxymethyl Cellulose/Agar-Based Functional Films Hybridized with Alizarin and Grapefruit Seed Extract.
35006859	5	38	theme	water	668:672	arg1	properties					688:697	the water vapor barrier properties	664:697	the water vapor barrier properties	664:697	Also, the addition of alizarin and GSE slightly improved the water vapor barrier properties but did not affect the thermal stability of the film.
35006859	5	39	theme	film	747:750	arg1	stability					730:738	the thermal stability	718:738	the thermal stability of the film	718:750	Also, the addition of alizarin and GSE slightly improved the water vapor barrier properties but did not affect the thermal stability of the film.
35006859	8	40	theme	antioxidant	1144:1154	arg1	action					1156:1161	an intense antioxidant action	1133:1161	an intense antioxidant action	1133:1161	The film also showed potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes, and showed an intense antioxidant action.
35006859	1	41	theme	functional	156:165	arg1	films					179:183	Carboxymethyl cellulose/agar-based functional halochromic films	121:183	Carboxymethyl cellulose/agar-based functional halochromic films	121:183	Carboxymethyl cellulose/agar-based functional halochromic films were fabricated by adding alizarin and grapefruit seed extract (GSE).
35006859	5	42	theme	vapor	674:678	arg1	properties					688:697	the water vapor barrier properties	664:697	the water vapor barrier properties	664:697	Also, the addition of alizarin and GSE slightly improved the water vapor barrier properties but did not affect the thermal stability of the film.
35006859	1	43	theme	halochromic	167:177	arg1	films					179:183	Carboxymethyl cellulose/agar-based functional halochromic films	121:183	Carboxymethyl cellulose/agar-based functional halochromic films	121:183	Carboxymethyl cellulose/agar-based functional halochromic films were fabricated by adding alizarin and grapefruit seed extract (GSE).
35006859	7	44	with	function	977:984	arg1	reversibility					914:926	color reversibility	908:926	color reversibility	908:926	The composite film showed an excellent pH-dependent color change with color reversibility and color stability and a volatile gas detection function.
35006859	7	44	with	function	977:984	arg1	stability					938:946	color stability	932:946	color stability	932:946	The composite film showed an excellent pH-dependent color change with color reversibility and color stability and a volatile gas detection function.
35006859	5	45	theme	barrier	680:686	arg1	properties					688:697	the water vapor barrier properties	664:697	the water vapor barrier properties	664:697	Also, the addition of alizarin and GSE slightly improved the water vapor barrier properties but did not affect the thermal stability of the film.
35006859	2	46	theme	polymer	296:302	arg1	matrix					304:309	the polymer matrix	292:309	the polymer matrix	292:309	The fillers were evenly dispersed in the polymer matrix to form compatible composite films.
35006859	8	47	theme	intense	1136:1142	arg1	action					1156:1161	an intense antioxidant action	1133:1161	an intense antioxidant action	1133:1161	The film also showed potent antimicrobial activity against foodborne pathogenic bacteria, Escherichia coli and Listeria monocytogenes, and showed an intense antioxidant action.
35006859	3	48	theme	excellent	477:485	arg1	properties					504:513	excellent color indicating properties	477:513	excellent color indicating properties	477:513	The addition of alizarin has improved the film's mechanical strength (20%) and water resistance (40%) with potent antioxidant and excellent color indicating properties.
35006859	7	49	theme	pH-dependent	877:888	arg1	change					896:901	an excellent pH-dependent color change	864:901	an excellent pH-dependent color change with color reversibility and color stability	864:946	The composite film showed an excellent pH-dependent color change with color reversibility and color stability and a volatile gas detection function.
35006859	3	50	theme	alizarin	363:370	arg1	addition					351:358	The addition	347:358	The addition of alizarin	347:370	The addition of alizarin has improved the film's mechanical strength (20%) and water resistance (40%) with potent antioxidant and excellent color indicating properties.
35006859	6	51	theme	adequate	815:822	arg1	transparency					824:835	adequate transparency	815:835	adequate transparency	815:835	The composite film also exhibited UV blocking properties with adequate transparency.
35006859	7	52	theme	color	908:912	arg1	reversibility					914:926	color reversibility	908:926	color reversibility	908:926	The composite film showed an excellent pH-dependent color change with color reversibility and color stability and a volatile gas detection function.
35006859	0	53	theme	Alizarin	83:90	arg1	Extract					112:118	Alizarin and Grapefruit Seed Extract	83:118	Extract	112:118	Fabrication of Carboxymethyl Cellulose/Agar-Based Functional Films Hybridized with Alizarin and Grapefruit Seed Extract.
35006859	7	54	theme	color	890:894	arg1	change					896:901	an excellent pH-dependent color change	864:901	an excellent pH-dependent color change with color reversibility and color stability	864:946	The composite film showed an excellent pH-dependent color change with color reversibility and color stability and a volatile gas detection function.
34973758	4	0	dep	SD	892:893	arg1	HPLC					905:908	HPLC	905:908	HPLC	905:908	Successfully synthesized ZrO2CTS-HC as confirmed by theoretical and various characterization techniques depicted photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical.
34973758	1	1	theme	conventional	244:255	arg1	plants					278:283	the conventional wastewater treatment plants	240:283	the conventional wastewater treatment plants for their complete removal	240:310	Emerging contaminants (ECs) are often detected in water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal.
34973758	0	2	theme	contaminants	76:87	arg1	photodegradation					41:56	simultaneous photodegradation	28:56	simultaneous photodegradation of three emerging contaminants and antibacterial application	28:117	ZrO2@chitosan composite for simultaneous photodegradation of three emerging contaminants and antibacterial application.
34973758	3	3	theme	visible	663:669	arg1	irradiation					677:687	visible light irradiation	663:687	visible light irradiation	663:687	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	2	4	theme	tertiary	358:365	arg1	treatment					367:375	a tertiary treatment	356:375	a tertiary treatment	356:375	Elimination of ECs using photocatalysis as a tertiary treatment can be a sustainable option for the reuse wastewater.
34973758	2	4	theme	tertiary	358:365	arg1	photocatalysis					338:351	photocatalysis	338:351	photocatalysis	338:351	Elimination of ECs using photocatalysis as a tertiary treatment can be a sustainable option for the reuse wastewater.
34973758	1	5	theme	wastewater	257:266	arg1	plants					278:283	the conventional wastewater treatment plants	240:283	the conventional wastewater treatment plants for their complete removal	240:310	Emerging contaminants (ECs) are often detected in water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal.
34973758	0	6	theme	application	107:117	arg1	photodegradation					41:56	simultaneous photodegradation	28:56	simultaneous photodegradation of three emerging contaminants and antibacterial application	28:117	ZrO2@chitosan composite for simultaneous photodegradation of three emerging contaminants and antibacterial application.
34973758	3	7	theme	light	671:675	arg1	irradiation					677:687	visible light irradiation	663:687	visible light irradiation	663:687	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	4	8	theme	characterization	766:781	arg1	techniques					783:792	theoretical and various characterization techniques	742:792	techniques	783:792	Successfully synthesized ZrO2CTS-HC as confirmed by theoretical and various characterization techniques depicted photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical.
34973758	4	9	theme	theoretical	742:752	arg1	techniques					783:792	theoretical and various characterization techniques	742:792	techniques	783:792	Successfully synthesized ZrO2CTS-HC as confirmed by theoretical and various characterization techniques depicted photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical.
34973758	1	10	theme	treatment	268:276	arg1	plants					278:283	the conventional wastewater treatment plants	240:283	the conventional wastewater treatment plants for their complete removal	240:310	Emerging contaminants (ECs) are often detected in water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal.
34973758	0	11	theme	antibacterial	93:105	arg1	application					107:117	antibacterial application	93:117	antibacterial application	93:117	ZrO2@chitosan composite for simultaneous photodegradation of three emerging contaminants and antibacterial application.
34973758	4	12	theme	various	758:764	arg1	techniques					783:792	theoretical and various characterization techniques	742:792	techniques	783:792	Successfully synthesized ZrO2CTS-HC as confirmed by theoretical and various characterization techniques depicted photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical.
34973758	3	13	theme	multiple	571:578	arg1	ECs					580:582	multiple ECs	571:582	multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA)	571:655	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	1	14	theme	plants	278:283	arg1	inefficiency					224:235	inefficiency	224:235	inefficiency of the conventional wastewater treatment plants for their complete removal	224:310	Emerging contaminants (ECs) are often detected in water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal.
34973758	3	15	theme	zirconia	484:491	arg1	ZrO2CTS-HC					511:520	ZrO2CTS-HC	511:520	ZrO2CTS-HC	511:520	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	3	15	theme	zirconia	484:491	arg1	composite					500:508	a photocatalyst, chitosan-based zirconia hybrid composite	452:508	a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation	452:687	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	3	16	theme	simultaneous	543:554	arg1	degradation					556:566	the individual/ simultaneous degradation	527:566	the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation	527:687	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	2	17	theme	sustainable	386:396	arg1	option					398:403	a sustainable option	384:403	a sustainable option for the reuse wastewater	384:428	Elimination of ECs using photocatalysis as a tertiary treatment can be a sustainable option for the reuse wastewater.
34973758	2	17	theme	sustainable	386:396	arg1	Elimination					313:323	Elimination	313:323	Elimination of ECs using photocatalysis as a tertiary treatment	313:375	Elimination of ECs using photocatalysis as a tertiary treatment can be a sustainable option for the reuse wastewater.
34973758	1	18	theme	water	170:174	arg1	bodies					176:181	water bodies	170:181	water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal	170:310	Emerging contaminants (ECs) are often detected in water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal.
34973758	4	19	theme	hydroxyl	933:940	arg1	radical					942:948	the reactive hydroxyl radical	920:948	the reactive hydroxyl radical	920:948	Successfully synthesized ZrO2CTS-HC as confirmed by theoretical and various characterization techniques depicted photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical.
34973758	4	20	theme	%	856:856	arg1	efficiency					820:829	photodegradation efficiency	803:829	photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical	803:948	Successfully synthesized ZrO2CTS-HC as confirmed by theoretical and various characterization techniques depicted photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical.
34973758	0	21	theme	@	4:4	arg1	chitosan					5:12	ZrO2@chitosan	0:12	ZrO2@chitosan	0:12	ZrO2@chitosan composite for simultaneous photodegradation of three emerging contaminants and antibacterial application.
34973758	1	22	located	detected	158:165	arg2	contaminants					129:140	Emerging contaminants	120:140	Emerging contaminants (ECs)	120:146	Emerging contaminants (ECs) are often detected in water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal.
34973758	1	22	located	detected	158:165	arg1	bodies					176:181	water bodies	170:181	water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal	170:310	Emerging contaminants (ECs) are often detected in water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal.
34973758	1	22	located	detected	158:165	arg2	ECs					143:145	ECs	143:145	ECs	143:145	Emerging contaminants (ECs) are often detected in water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal.
34973758	2	23	theme	ECs	328:330	arg1	option					398:403	a sustainable option	384:403	a sustainable option for the reuse wastewater	384:428	Elimination of ECs using photocatalysis as a tertiary treatment can be a sustainable option for the reuse wastewater.
34973758	2	23	theme	ECs	328:330	arg1	Elimination					313:323	Elimination	313:323	Elimination of ECs using photocatalysis as a tertiary treatment	313:375	Elimination of ECs using photocatalysis as a tertiary treatment can be a sustainable option for the reuse wastewater.
34973758	1	24	theme	due	183:185	arg1	bodies					176:181	water bodies	170:181	water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal	170:310	Emerging contaminants (ECs) are often detected in water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal.
34973758	0	25	theme	ZrO2	0:3	arg1	chitosan					5:12	ZrO2@chitosan	0:12	ZrO2@chitosan	0:12	ZrO2@chitosan composite for simultaneous photodegradation of three emerging contaminants and antibacterial application.
34973758	6	26	theme	tertiary	1181:1188	arg1	treatment					1190:1198	tertiary treatment	1181:1198	tertiary treatment	1181:1198	ZrO2CTS-HC can be a good option for elimination of residual ECs during tertiary treatment.
34973758	4	27	dep	ZrO2CTS-HC	715:724	arg1	confirmed					729:737	confirmed	729:737	confirmed by theoretical and various characterization techniques	729:792	Successfully synthesized ZrO2CTS-HC as confirmed by theoretical and various characterization techniques depicted photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical.
34973758	4	28	theme	91.11	834:838	arg1	efficiency					820:829	photodegradation efficiency	803:829	photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical	803:948	Successfully synthesized ZrO2CTS-HC as confirmed by theoretical and various characterization techniques depicted photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical.
34973758	3	29	theme	ECs	580:582	arg1	degradation					556:566	the individual/ simultaneous degradation	527:566	the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation	527:687	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	1	30	theme	complete	295:302	arg1	removal					304:310	their complete removal	289:310	their complete removal	289:310	Emerging contaminants (ECs) are often detected in water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal.
34973758	5	31	theme	degradation	960:970	arg1	mechanism					972:980	Probable degradation mechanism	951:980	Probable degradation mechanism supported by LC-MS/MS, COD and TOC along with reusability and antibacterial ability towards E.Coli & S.aureus	951:1090	Probable degradation mechanism supported by LC-MS/MS, COD and TOC along with reusability and antibacterial ability towards E.Coli & S.aureus is also reported.
34973758	3	32	theme	4-hydroxybenzoic	628:643	arg1	4-HA					651:654	4-HA	651:654	4-HA	651:654	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	3	32	theme	4-hydroxybenzoic	628:643	arg1	acid					645:648	4-hydroxybenzoic acid	628:648	4-hydroxybenzoic acid (4-HA)	628:655	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	3	32	theme	4-hydroxybenzoic	628:643	arg1	red					595:597	red	595:597	red	595:597	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	1	33	theme	Emerging	120:127	arg1	ECs					143:145	ECs	143:145	ECs	143:145	Emerging contaminants (ECs) are often detected in water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal.
34973758	1	33	theme	Emerging	120:127	arg1	contaminants					129:140	Emerging contaminants	120:140	Emerging contaminants (ECs)	120:146	Emerging contaminants (ECs) are often detected in water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal.
34973758	1	34	theme	prevalent	196:204	arg1	use					206:208	their prevalent use	190:208	their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal	190:310	Emerging contaminants (ECs) are often detected in water bodies due to their prevalent use combined with inefficiency of the conventional wastewater treatment plants for their complete removal.
34973758	0	35	theme	simultaneous	28:39	arg1	photodegradation					41:56	simultaneous photodegradation	28:56	simultaneous photodegradation of three emerging contaminants and antibacterial application	28:117	ZrO2@chitosan composite for simultaneous photodegradation of three emerging contaminants and antibacterial application.
34973758	3	36	theme	photocatalyst	454:466	arg1	ZrO2CTS-HC					511:520	ZrO2CTS-HC	511:520	ZrO2CTS-HC	511:520	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	3	36	theme	photocatalyst	454:466	arg1	composite					500:508	a photocatalyst, chitosan-based zirconia hybrid composite	452:508	a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation	452:687	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	4	37	theme	69.11	841:845	arg1	efficiency					820:829	photodegradation efficiency	803:829	photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical	803:948	Successfully synthesized ZrO2CTS-HC as confirmed by theoretical and various characterization techniques depicted photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical.
34973758	2	38	theme	reuse	413:417	arg1	wastewater					419:428	the reuse wastewater	409:428	the reuse wastewater	409:428	Elimination of ECs using photocatalysis as a tertiary treatment can be a sustainable option for the reuse wastewater.
34973758	4	39	theme	reactive	924:931	arg1	radical					942:948	the reactive hydroxyl radical	920:948	the reactive hydroxyl radical	920:948	Successfully synthesized ZrO2CTS-HC as confirmed by theoretical and various characterization techniques depicted photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical.
34973758	5	40	theme	Probable	951:958	arg1	mechanism					972:980	Probable degradation mechanism	951:980	Probable degradation mechanism supported by LC-MS/MS, COD and TOC along with reusability and antibacterial ability towards E.Coli & S.aureus	951:1090	Probable degradation mechanism supported by LC-MS/MS, COD and TOC along with reusability and antibacterial ability towards E.Coli & S.aureus is also reported.
34973758	4	41	theme	synthesized	703:713	arg1	ZrO2CTS-HC					715:724	Successfully synthesized ZrO2CTS-HC	690:724	Successfully synthesized ZrO2CTS-HC as confirmed by theoretical and various characterization techniques	690:792	Successfully synthesized ZrO2CTS-HC as confirmed by theoretical and various characterization techniques depicted photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical.
34973758	6	42	theme	residual	1161:1168	arg1	ECs					1170:1172	residual ECs	1161:1172	residual ECs	1161:1172	ZrO2CTS-HC can be a good option for elimination of residual ECs during tertiary treatment.
34973758	3	43	dep	photocatalyst	454:466	arg1	chitosan-based					469:482	chitosan-based	469:482	chitosan-based	469:482	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	3	44	theme	hybrid	493:498	arg1	ZrO2CTS-HC					511:520	ZrO2CTS-HC	511:520	ZrO2CTS-HC	511:520	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	3	44	theme	hybrid	493:498	arg1	composite					500:508	a photocatalyst, chitosan-based zirconia hybrid composite	452:508	a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation	452:687	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	6	45	theme	good	1130:1133	arg1	option					1135:1140	a good option	1128:1140	a good option for elimination of residual ECs during tertiary treatment	1128:1198	ZrO2CTS-HC can be a good option for elimination of residual ECs during tertiary treatment.
34973758	6	45	theme	good	1130:1133	arg1	ZrO2CTS-HC					1110:1119	ZrO2CTS-HC	1110:1119	ZrO2CTS-HC	1110:1119	ZrO2CTS-HC can be a good option for elimination of residual ECs during tertiary treatment.
34973758	4	46	theme	photodegradation	803:818	arg1	efficiency					820:829	photodegradation efficiency	803:829	photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical	803:948	Successfully synthesized ZrO2CTS-HC as confirmed by theoretical and various characterization techniques depicted photodegradation efficiency of 91.11, 69.11 and 78.40% for CR, MO and 4-HA respectively (SD 0.5-0.95; HPLC) aided by the reactive hydroxyl radical.
34973758	0	47	theme	emerging	67:74	arg1	contaminants					76:87	three emerging contaminants	61:87	three emerging contaminants	61:87	ZrO2@chitosan composite for simultaneous photodegradation of three emerging contaminants and antibacterial application.
34973758	5	48	theme	antibacterial	1044:1056	arg1	ability					1058:1064	antibacterial ability	1044:1064	antibacterial ability	1044:1064	Probable degradation mechanism supported by LC-MS/MS, COD and TOC along with reusability and antibacterial ability towards E.Coli & S.aureus is also reported.
34973758	3	49	theme	Methyl	605:610	arg1	orange					612:617	Methyl orange	605:617	Methyl orange (MO)	605:622	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	3	49	theme	Methyl	605:610	arg1	red					595:597	red	595:597	red	595:597	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	3	49	theme	Methyl	605:610	arg1	MO					620:621	MO	620:621	MO	620:621	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
34973758	6	50	theme	ECs	1170:1172	arg1	elimination					1146:1156	elimination	1146:1156	elimination of residual ECs during tertiary treatment	1146:1198	ZrO2CTS-HC can be a good option for elimination of residual ECs during tertiary treatment.
34973758	3	51	theme	individual/	531:541	arg1	degradation					556:566	the individual/ simultaneous degradation	527:566	the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation	527:687	Reported herewith is a photocatalyst, chitosan-based zirconia hybrid composite (ZrO2CTS-HC) for the individual/ simultaneous degradation of multiple ECs like Congo red (CR), Methyl orange (MO) and 4-hydroxybenzoic acid (4-HA) under visible light irradiation.
31295733	0	0	theme	tissue	87:92	arg1	scaffolds					94:102	freeze-cast tissue scaffolds	75:102	freeze-cast tissue scaffolds	75:102	Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.
31295733	6	1	theme	biocompatibility	1004:1019	arg1	studies					1021:1027	systematic biocompatibility studies	993:1027	systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin	993:1163	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	0	2	theme	freeze-cast	75:85	arg1	scaffolds					94:102	freeze-cast tissue scaffolds	75:102	freeze-cast tissue scaffolds	75:102	Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.
31295733	7	3	theme	Geometric	1166:1174	arg1	models					1176:1181	Geometric models	1166:1181	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness	1166:1259	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	7	3	theme	Geometric	1166:1174	arg1	metric					1325:1330	a powerful and objective metric	1300:1330	a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds	1300:1413	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	6	4	theme	systematic	993:1002	arg1	studies					1021:1027	systematic biocompatibility studies	993:1027	systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin	993:1163	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	3	5	theme	objective	677:685	arg1	approach					687:694	a more objective approach	670:694	a more objective approach to their selection for a given application	670:737	Advantages of this new technique are that it enables, on the one hand, a more complete and objective comparison of scaffolds with differing compositions, architectures, and mechanical properties, and, on the other, a more objective approach to their selection for a given application.
31295733	4	6	theme	biocompatibility	878:893	arg1	testing					895:901	biocompatibility testing	878:901	biocompatibility testing	878:901	In this contribution, we focus on freeze-cast polymeric scaffolds for tissue regeneration and their subcutaneous implantation in mice for biocompatibility testing.
31295733	2	7	theme	biocompatibility	295:310	arg1	straightforward					314:328	biocompatibility a straightforward	295:328	biocompatibility a straightforward	295:328	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
31295733	2	8	theme	a	312:312	arg1	straightforward					314:328	biocompatibility a straightforward	295:328	biocompatibility a straightforward	295:328	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
31295733	0	9	theme	scaffolds	94:102	arg1	performance					60:70	performance	60:70	performance	60:70	Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.
31295733	0	9	theme	scaffolds	94:102	arg1	biocompatibility					39:54	biocompatibility	39:54	biocompatibility	39:54	Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.
31295733	4	10	from	implantation	853:864	arg1	mice					869:872	mice	869:872	mice	869:872	In this contribution, we focus on freeze-cast polymeric scaffolds for tissue regeneration and their subcutaneous implantation in mice for biocompatibility testing.
31295733	6	11	dep	criteria	1056:1063	arg1	collagen-nanocellulose					1130:1151	EDC-NHS-crosslinked bovine collagen-nanocellulose	1103:1151	EDC-NHS-crosslinked bovine collagen-nanocellulose	1103:1151	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	6	11	dep	criteria	1056:1063	arg1	chitin					1158:1163	chitin	1158:1163	chitin	1158:1163	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	6	11	dep	criteria	1056:1063	arg1	criteria					1056:1063	histopathological criteria	1038:1063	histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin	1038:1163	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	6	11	dep	criteria	1056:1063	arg1	collagen					1093:1100	EDC-NHS-crosslinked bovine collagen	1066:1100	EDC-NHS-crosslinked bovine collagen	1066:1100	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	3	12	theme	objective	546:554	arg1	comparison					556:565	a more complete and objective comparison	526:565	a more complete and objective comparison of scaffolds with differing compositions, architectures, and mechanical properties	526:648	Advantages of this new technique are that it enables, on the one hand, a more complete and objective comparison of scaffolds with differing compositions, architectures, and mechanical properties, and, on the other, a more objective approach to their selection for a given application.
31295733	7	13	theme	encapsulation	1237:1249	arg1	thickness					1251:1259	encapsulation thickness	1237:1259	encapsulation thickness	1237:1259	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	7	14	theme	objective	1315:1323	arg1	models					1176:1181	Geometric models	1166:1181	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness	1166:1259	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	7	14	theme	objective	1315:1323	arg1	metric					1325:1330	a powerful and objective metric	1300:1330	a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds	1300:1413	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	6	15	theme	EDC-NHS-crosslinked	1066:1084	arg1	criteria					1056:1063	histopathological criteria	1038:1063	histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin	1038:1163	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	6	15	theme	EDC-NHS-crosslinked	1066:1084	arg1	collagen					1093:1100	EDC-NHS-crosslinked bovine collagen	1066:1100	EDC-NHS-crosslinked bovine collagen	1066:1100	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	1	16	theme	scaffolds	179:187	arg1	assessment					158:167	the in vivo assessment	146:167	the in vivo assessment of tissue scaffolds to evaluate biocompatibility	146:216	Quantitative methods are little used for the in vivo assessment of tissue scaffolds to evaluate biocompatibility.
31295733	6	17	theme	bovine	1123:1128	arg1	collagen-nanocellulose					1130:1151	EDC-NHS-crosslinked bovine collagen-nanocellulose	1103:1151	EDC-NHS-crosslinked bovine collagen-nanocellulose	1103:1151	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	6	17	theme	bovine	1123:1128	arg1	criteria					1056:1063	histopathological criteria	1038:1063	histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin	1038:1163	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	3	18	theme	complete	533:540	arg1	comparison					556:565	a more complete and objective comparison	526:565	a more complete and objective comparison of scaffolds with differing compositions, architectures, and mechanical properties	526:648	Advantages of this new technique are that it enables, on the one hand, a more complete and objective comparison of scaffolds with differing compositions, architectures, and mechanical properties, and, on the other, a more objective approach to their selection for a given application.
31295733	1	19	theme	tissue	172:177	arg1	scaffolds					179:187	tissue scaffolds	172:187	tissue scaffolds	172:187	Quantitative methods are little used for the in vivo assessment of tissue scaffolds to evaluate biocompatibility.
31295733	7	20	theme	performance	1383:1393	arg1	assessment					1348:1357	the in vivo assessment	1336:1357	the in vivo assessment of biocompatibility and performance of tissue scaffolds	1336:1413	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	6	21	link	EDC-NHS-crosslinked	1066:1084	arg1	criteria					1056:1063	histopathological criteria	1038:1063	histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin	1038:1163	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	6	21	link	EDC-NHS-crosslinked	1066:1084	arg1	collagen					1093:1100	EDC-NHS-crosslinked bovine collagen	1066:1100	EDC-NHS-crosslinked bovine collagen	1066:1100	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	2	22	theme	geometric	331:339	arg1	analysis					341:348	geometric analysis	331:348	geometric analysis for the quantitative assessment of encapsulation thickness	331:407	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
31295733	2	23	theme	cross-sectional	410:424	arg1	area					426:429	cross-sectional area	410:429	cross-sectional area	410:429	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
31295733	0	24	theme	Quantitative	0:11	arg1	evaluation					13:22	Quantitative evaluation	0:22	Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.	0:103	Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.
31295733	6	25	link	EDC-NHS-crosslinked	1103:1121	arg1	collagen-nanocellulose					1130:1151	EDC-NHS-crosslinked bovine collagen-nanocellulose	1103:1151	EDC-NHS-crosslinked bovine collagen-nanocellulose	1103:1151	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	6	25	link	EDC-NHS-crosslinked	1103:1121	arg1	criteria					1056:1063	histopathological criteria	1038:1063	histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin	1038:1163	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	4	26	theme	subcutaneous	840:851	arg1	implantation					853:864	their subcutaneous implantation	834:864	their subcutaneous implantation in mice for biocompatibility testing	834:901	In this contribution, we focus on freeze-cast polymeric scaffolds for tissue regeneration and their subcutaneous implantation in mice for biocompatibility testing.
31295733	6	27	theme	EDC-NHS-crosslinked	1103:1121	arg1	collagen-nanocellulose					1130:1151	EDC-NHS-crosslinked bovine collagen-nanocellulose	1103:1151	EDC-NHS-crosslinked bovine collagen-nanocellulose	1103:1151	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	6	27	theme	EDC-NHS-crosslinked	1103:1121	arg1	criteria					1056:1063	histopathological criteria	1038:1063	histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin	1038:1163	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	0	28	dep	in	31:32	arg1	vivo					34:37	vivo	34:37	vivo	34:37	Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.
31295733	2	29	theme	straightforward	314:328	arg1	measure					284:290	a measure	282:290	a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape	282:452	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
31295733	6	30	theme	bovine	1086:1091	arg1	criteria					1056:1063	histopathological criteria	1038:1063	histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin	1038:1163	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	6	30	theme	bovine	1086:1091	arg1	collagen					1093:1100	EDC-NHS-crosslinked bovine collagen	1066:1100	EDC-NHS-crosslinked bovine collagen	1066:1100	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	3	31	theme	given	721:725	arg1	application					727:737	a given application	719:737	a given application	719:737	Advantages of this new technique are that it enables, on the one hand, a more complete and objective comparison of scaffolds with differing compositions, architectures, and mechanical properties, and, on the other, a more objective approach to their selection for a given application.
31295733	1	32	dep	in	150:151	arg1	vivo					153:156	vivo	153:156	vivo	153:156	Quantitative methods are little used for the in vivo assessment of tissue scaffolds to evaluate biocompatibility.
31295733	2	33	theme	shape	448:452	arg1	measure					284:290	a measure	282:290	a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape	282:452	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
31295733	7	34	theme	scaffold	1205:1212	arg1	size					1214:1217	scaffold size	1205:1217	scaffold size	1205:1217	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	7	35	dep	in	1340:1341	arg1	vivo					1343:1346	vivo	1343:1346	vivo	1343:1346	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	3	36	theme	technique	478:486	arg1	Advantages					455:464	Advantages	455:464	Advantages of this new technique	455:486	Advantages of this new technique are that it enables, on the one hand, a more complete and objective comparison of scaffolds with differing compositions, architectures, and mechanical properties, and, on the other, a more objective approach to their selection for a given application.
31295733	2	37	theme	biomaterial	436:446	arg1	shape					448:452	biomaterial shape	436:452	biomaterial shape	436:452	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
31295733	0	38	theme	in	31:32	arg1	biocompatibility					39:54	biocompatibility	39:54	biocompatibility	39:54	Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.
31295733	7	39	theme	biocompatibility	1362:1377	arg1	assessment					1348:1357	the in vivo assessment	1336:1357	the in vivo assessment of biocompatibility and performance of tissue scaffolds	1336:1413	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	2	40	theme	histological	241:252	arg1	techniques					254:263	current histological techniques	233:263	current histological techniques	233:263	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
31295733	4	41	from	regeneration	817:828	arg1	mice					869:872	mice	869:872	mice	869:872	In this contribution, we focus on freeze-cast polymeric scaffolds for tissue regeneration and their subcutaneous implantation in mice for biocompatibility testing.
31295733	4	42	theme	tissue	810:815	arg1	regeneration					817:828	tissue regeneration	810:828	tissue regeneration	810:828	In this contribution, we focus on freeze-cast polymeric scaffolds for tissue regeneration and their subcutaneous implantation in mice for biocompatibility testing.
31295733	2	43	theme	current	233:239	arg1	techniques					254:263	current histological techniques	233:263	current histological techniques	233:263	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
31295733	2	44	theme	quantitative	358:369	arg1	assessment					371:380	the quantitative assessment	354:380	the quantitative assessment of encapsulation thickness	354:407	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
31295733	0	45	theme	biocompatibility	39:54	arg1	evaluation					13:22	Quantitative evaluation	0:22	Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.	0:103	Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.
31295733	1	46	theme	in	150:151	arg1	assessment					158:167	the in vivo assessment	146:167	the in vivo assessment of tissue scaffolds to evaluate biocompatibility	146:216	Quantitative methods are little used for the in vivo assessment of tissue scaffolds to evaluate biocompatibility.
31295733	5	47	theme	different	921:929	arg1	types					940:944	seven different scaffold types	915:944	seven different scaffold types	915:944	Initially, seven different scaffold types are screened.
31295733	3	48	theme	scaffolds	570:578	arg1	comparison					556:565	a more complete and objective comparison	526:565	a more complete and objective comparison of scaffolds with differing compositions, architectures, and mechanical properties	526:648	Advantages of this new technique are that it enables, on the one hand, a more complete and objective comparison of scaffolds with differing compositions, architectures, and mechanical properties, and, on the other, a more objective approach to their selection for a given application.
31295733	7	49	theme	tissue	1398:1403	arg1	scaffolds					1405:1413	tissue scaffolds	1398:1413	tissue scaffolds	1398:1413	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	3	50	theme	mechanical	628:637	arg1	properties					639:648	mechanical properties	628:648	mechanical properties	628:648	Advantages of this new technique are that it enables, on the one hand, a more complete and objective comparison of scaffolds with differing compositions, architectures, and mechanical properties, and, on the other, a more objective approach to their selection for a given application.
31295733	5	51	theme	scaffold	931:938	arg1	types					940:944	seven different scaffold types	915:944	seven different scaffold types	915:944	Initially, seven different scaffold types are screened.
31295733	1	52	theme	Quantitative	105:116	arg1	methods					118:124	Quantitative methods	105:124	Quantitative methods	105:124	Quantitative methods are little used for the in vivo assessment of tissue scaffolds to evaluate biocompatibility.
31295733	6	53	theme	histopathological	1038:1054	arg1	criteria					1056:1063	histopathological criteria	1038:1063	histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin	1038:1163	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	6	53	theme	histopathological	1038:1054	arg1	chitin					1158:1163	chitin	1158:1163	chitin	1158:1163	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	6	53	theme	histopathological	1038:1054	arg1	collagen-nanocellulose					1130:1151	EDC-NHS-crosslinked bovine collagen-nanocellulose	1103:1151	EDC-NHS-crosslinked bovine collagen-nanocellulose	1103:1151	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	6	53	theme	histopathological	1038:1054	arg1	collagen					1093:1100	EDC-NHS-crosslinked bovine collagen	1066:1100	EDC-NHS-crosslinked bovine collagen	1066:1100	Of these, three are selected for systematic biocompatibility studies based on histopathological criteria: EDC-NHS-crosslinked bovine collagen, EDC-NHS-crosslinked bovine collagen-nanocellulose, and chitin.
31295733	7	54	theme	scaffolds	1405:1413	arg1	performance					1383:1393	performance	1383:1393	performance	1383:1393	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	7	54	theme	scaffolds	1405:1413	arg1	biocompatibility					1362:1377	biocompatibility	1362:1377	biocompatibility	1362:1377	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	2	55	theme	analysis	341:348	arg1	measure					284:290	a measure	282:290	a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape	282:452	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
31295733	3	56	theme	new	474:476	arg1	technique					478:486	this new technique	469:486	this new technique	469:486	Advantages of this new technique are that it enables, on the one hand, a more complete and objective comparison of scaffolds with differing compositions, architectures, and mechanical properties, and, on the other, a more objective approach to their selection for a given application.
31295733	4	57	theme	polymeric	786:794	arg1	scaffolds					796:804	freeze-cast polymeric scaffolds	774:804	freeze-cast polymeric scaffolds for tissue regeneration and their subcutaneous implantation in mice for biocompatibility testing	774:901	In this contribution, we focus on freeze-cast polymeric scaffolds for tissue regeneration and their subcutaneous implantation in mice for biocompatibility testing.
31295733	7	58	theme	in	1340:1341	arg1	assessment					1348:1357	the in vivo assessment	1336:1357	the in vivo assessment of biocompatibility and performance of tissue scaffolds	1336:1413	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	2	59	theme	thickness	399:407	arg1	assessment					371:380	the quantitative assessment	354:380	the quantitative assessment of encapsulation thickness	354:407	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
31295733	2	60	theme	area	426:429	arg1	measure					284:290	a measure	282:290	a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape	282:452	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
31295733	0	61	theme	performance	60:70	arg1	evaluation					13:22	Quantitative evaluation	0:22	Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.	0:103	Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds.
31295733	4	62	theme	freeze-cast	774:784	arg1	scaffolds					796:804	freeze-cast polymeric scaffolds	774:804	freeze-cast polymeric scaffolds for tissue regeneration and their subcutaneous implantation in mice for biocompatibility testing	774:901	In this contribution, we focus on freeze-cast polymeric scaffolds for tissue regeneration and their subcutaneous implantation in mice for biocompatibility testing.
31295733	7	63	theme	powerful	1302:1309	arg1	models					1176:1181	Geometric models	1166:1181	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness	1166:1259	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	7	63	theme	powerful	1302:1309	arg1	metric					1325:1330	a powerful and objective metric	1300:1330	a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds	1300:1413	Geometric models developed to quantify scaffold size, ovalization, and encapsulation thickness are tested, evaluated, and found to be a powerful and objective metric for the in vivo assessment of biocompatibility and performance of tissue scaffolds.
31295733	2	64	theme	encapsulation	385:397	arg1	thickness					399:407	encapsulation thickness	385:407	encapsulation thickness	385:407	To complement current histological techniques, we introduce as a measure of biocompatibility a straightforward, geometric analysis for the quantitative assessment of encapsulation thickness, cross-sectional area, and biomaterial shape.
35140704	1	0	theme	protein-2	148:156	arg1	complex					165:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex	92:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex	92:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex is considered the major receptor of the innate immune system to recognize lipopolysaccharides (LPSs).
35140704	1	1	theme	system	227:232	arg1	receptor					197:204	the major receptor	187:204	the major receptor of the innate immune system	187:232	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex is considered the major receptor of the innate immune system to recognize lipopolysaccharides (LPSs).
35140704	0	2	theme	Atypical	78:85	arg1	LPS					87:89	Low Endotoxic Atypical LPS	64:89	Low Endotoxic Atypical LPS	64:89	Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS.
35140704	7	3	theme	first	1100:1104	arg1	heterodimerization					1121:1138	the first time TLR4/TLR2 heterodimerization	1096:1138	the first time TLR4/TLR2 heterodimerization that is induced by atypical LPS	1096:1170	This study reveals for the first time TLR4/TLR2 heterodimerization that is induced by atypical LPS and may help to escape from recognition by the innate immune system.
35140704	2	4	theme	A	324:324	arg1	structures					353:362	different lipid A and core saccharide moiety structures	308:362	different lipid A and core saccharide moiety structures	308:362	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	5	5	theme	resonance	950:958	arg1	FRET					977:980	FRET	977:980	FRET	977:980	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	5	5	theme	resonance	950:958	arg1	transfer					967:974	fluorescence resonance energy transfer	937:974	fluorescence resonance energy transfer (FRET) in cells	937:990	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	4	6	theme	specific	711:718	arg1	agonist					730:736	a specific TLR4/TLR2 agonist	709:736	a specific TLR4/TLR2 agonist	709:736	In this study, we found that O. intermedium LPS exhibits a weak inflammatory activity compared to Escherichia coli LPS and, more importantly, is a specific TLR4/TLR2 agonist, able to signal through both receptors.
35140704	7	7	theme	atypical	1159:1166	arg1	LPS					1168:1170	atypical LPS	1159:1170	atypical LPS	1159:1170	This study reveals for the first time TLR4/TLR2 heterodimerization that is induced by atypical LPS and may help to escape from recognition by the innate immune system.
35140704	5	8	theme	energy	960:965	arg1	FRET					977:980	FRET	977:980	FRET	977:980	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	5	8	theme	energy	960:965	arg1	transfer					967:974	fluorescence resonance energy transfer	937:974	fluorescence resonance energy transfer (FRET) in cells	937:990	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	5	9	theme	TLR2/TLR4/MD-2	863:876	arg1	complex					890:896	a TLR2/TLR4/MD-2 heterodimer complex	861:896	a TLR2/TLR4/MD-2 heterodimer complex	861:896	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	5	10	theme	intermedium	811:821	arg1	LPS					823:825	O. intermedium LPS	808:825	O. intermedium LPS	808:825	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	5	11	theme	complex	890:896	arg1	formation					848:856	a favorable formation	836:856	a favorable formation	836:856	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	5	12	theme	O.	808:809	arg1	LPS					823:825	O. intermedium LPS	808:825	O. intermedium LPS	808:825	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	2	13	theme	well-studied	390:401	arg1	LPSs					419:422	the well-studied enterobacterial LPSs	386:422	the well-studied enterobacterial LPSs	386:422	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	5	14	theme	favorable	838:846	arg1	formation					848:856	a favorable formation	836:856	a favorable formation	836:856	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	1	15	theme	MD-2	159:162	arg1	complex					165:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex	92:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex	92:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex is considered the major receptor of the innate immune system to recognize lipopolysaccharides (LPSs).
35140704	2	16	theme	TLR2-dependent	437:450	arg1	response					452:459	a TLR2-dependent response	435:459	a TLR2-dependent response	435:459	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	5	17	theme	heterodimer	878:888	arg1	complex					890:896	a TLR2/TLR4/MD-2 heterodimer complex	861:896	a TLR2/TLR4/MD-2 heterodimer complex	861:896	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	2	18	theme	innate	464:469	arg1	cells					478:482	innate immune cells	464:482	innate immune cells	464:482	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	4	19	theme	able	739:742	arg1	agonist					730:736	a specific TLR4/TLR2 agonist	709:736	a specific TLR4/TLR2 agonist	709:736	In this study, we found that O. intermedium LPS exhibits a weak inflammatory activity compared to Escherichia coli LPS and, more importantly, is a specific TLR4/TLR2 agonist, able to signal through both receptors.
35140704	4	20	theme	inflammatory	628:639	arg1	activity					641:648	a weak inflammatory activity	621:648	a weak inflammatory activity	621:648	In this study, we found that O. intermedium LPS exhibits a weak inflammatory activity compared to Escherichia coli LPS and, more importantly, is a specific TLR4/TLR2 agonist, able to signal through both receptors.
35140704	2	21	theme	immune	471:476	arg1	cells					478:482	innate immune cells	464:482	innate immune cells	464:482	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	2	22	theme	atypical	289:296	arg1	LPSs					298:301	some atypical LPSs	284:301	some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs	284:422	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	4	23	theme	weak	623:626	arg1	activity					641:648	a weak inflammatory activity	621:648	a weak inflammatory activity	621:648	In this study, we found that O. intermedium LPS exhibits a weak inflammatory activity compared to Escherichia coli LPS and, more importantly, is a specific TLR4/TLR2 agonist, able to signal through both receptors.
35140704	5	24	theme	Molecular	778:786	arg1	analysis					796:803	Molecular docking analysis	778:803	Molecular docking analysis of O. intermedium LPS	778:825	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	2	25	theme	moiety	346:351	arg1	structures					353:362	different lipid A and core saccharide moiety structures	308:362	different lipid A and core saccharide moiety structures	308:362	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	0	26	theme	Interaction	23:33	arg1	Induction					0:8	Induction	0:8	Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS.	0:90	Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS.
35140704	7	27	theme	innate	1219:1224	arg1	system					1233:1238	the innate immune system	1215:1238	the innate immune system	1215:1238	This study reveals for the first time TLR4/TLR2 heterodimerization that is induced by atypical LPS and may help to escape from recognition by the innate immune system.
35140704	1	28	theme	Toll-like	96:104	arg1	TLR4					118:121	TLR4	118:121	TLR4	118:121	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex is considered the major receptor of the innate immune system to recognize lipopolysaccharides (LPSs).
35140704	1	28	theme	Toll-like	96:104	arg1	receptor					106:113	The Toll-like receptor 4	92:115	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex	92:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex is considered the major receptor of the innate immune system to recognize lipopolysaccharides (LPSs).
35140704	5	29	theme	fluorescence	937:948	arg1	FRET					977:980	FRET	977:980	FRET	977:980	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	5	29	theme	fluorescence	937:948	arg1	transfer					967:974	fluorescence resonance energy transfer	937:974	fluorescence resonance energy transfer (FRET) in cells	937:990	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	2	30	theme	enterobacterial	403:417	arg1	LPSs					419:422	the well-studied enterobacterial LPSs	386:422	the well-studied enterobacterial LPSs	386:422	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	0	31	theme	TLR4/TLR2	13:21	arg1	Interaction					23:33	TLR4/TLR2 Interaction	13:33	TLR4/TLR2 Interaction	13:33	Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS.
35140704	1	32	theme	receptor	106:113	arg1	complex					165:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex	92:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex	92:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex is considered the major receptor of the innate immune system to recognize lipopolysaccharides (LPSs).
35140704	1	33	theme	/myeloid	123:130	arg1	complex					165:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex	92:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex	92:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex is considered the major receptor of the innate immune system to recognize lipopolysaccharides (LPSs).
35140704	0	34	theme	Heterodimer	39:49	arg1	Formation					51:59	Heterodimer Formation	39:59	Heterodimer Formation	39:59	Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS.
35140704	3	35	theme	Ochrobactrum	485:496	arg1	pathogen					528:535	an opportunistic pathogen	511:535	an opportunistic pathogen	511:535	Ochrobactrum intermedium, an opportunistic pathogen, presents an atypical LPS.
35140704	3	35	theme	Ochrobactrum	485:496	arg1	intermedium					498:508	Ochrobactrum intermedium	485:508	Ochrobactrum intermedium	485:508	Ochrobactrum intermedium, an opportunistic pathogen, presents an atypical LPS.
35140704	2	36	with	LPSs	298:301	arg1	compositions					368:379	compositions	368:379	compositions	368:379	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	2	36	with	LPSs	298:301	arg1	structures					353:362	different lipid A and core saccharide moiety structures	308:362	different lipid A and core saccharide moiety structures	308:362	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	6	37	theme	important	1037:1045	arg1	role					1047:1050	an important role	1034:1050	an important role	1034:1050	Interestingly, the core saccharide plays an important role in this interaction.
35140704	1	38	theme	major	191:195	arg1	receptor					197:204	the major receptor	187:204	the major receptor of the innate immune system	187:232	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex is considered the major receptor of the innate immune system to recognize lipopolysaccharides (LPSs).
35140704	4	39	theme	intermedium	596:606	arg1	LPS					608:610	O. intermedium LPS	593:610	O. intermedium LPS	593:610	In this study, we found that O. intermedium LPS exhibits a weak inflammatory activity compared to Escherichia coli LPS and, more importantly, is a specific TLR4/TLR2 agonist, able to signal through both receptors.
35140704	4	40	theme	TLR4/TLR2	720:728	arg1	agonist					730:736	a specific TLR4/TLR2 agonist	709:736	a specific TLR4/TLR2 agonist	709:736	In this study, we found that O. intermedium LPS exhibits a weak inflammatory activity compared to Escherichia coli LPS and, more importantly, is a specific TLR4/TLR2 agonist, able to signal through both receptors.
35140704	7	41	theme	time	1106:1109	arg1	heterodimerization					1121:1138	the first time TLR4/TLR2 heterodimerization	1096:1138	the first time TLR4/TLR2 heterodimerization that is induced by atypical LPS	1096:1170	This study reveals for the first time TLR4/TLR2 heterodimerization that is induced by atypical LPS and may help to escape from recognition by the innate immune system.
35140704	6	42	theme	core	1012:1015	arg1	saccharide					1017:1026	the core saccharide	1008:1026	the core saccharide	1008:1026	Interestingly, the core saccharide plays an important role in this interaction.
35140704	2	43	theme	lipid	318:322	arg1	A					324:324	lipid A	318:324	lipid A	318:324	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	0	44	theme	Formation	51:59	arg1	Induction					0:8	Induction	0:8	Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS.	0:90	Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS.
35140704	5	45	theme	docking	788:794	arg1	analysis					796:803	Molecular docking analysis	778:803	Molecular docking analysis of O. intermedium LPS	778:825	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	2	46	theme	different	308:316	arg1	structures					353:362	different lipid A and core saccharide moiety structures	308:362	different lipid A and core saccharide moiety structures	308:362	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	7	47	theme	immune	1226:1231	arg1	system					1233:1238	the innate immune system	1215:1238	the innate immune system	1215:1238	This study reveals for the first time TLR4/TLR2 heterodimerization that is induced by atypical LPS and may help to escape from recognition by the innate immune system.
35140704	4	48	dep	agonist	730:736	arg1	exhibits					612:619	exhibits	612:619	exhibits a weak inflammatory activity compared to Escherichia coli LPS	612:681	In this study, we found that O. intermedium LPS exhibits a weak inflammatory activity compared to Escherichia coli LPS and, more importantly, is a specific TLR4/TLR2 agonist, able to signal through both receptors.
35140704	7	49	theme	TLR4/TLR2	1111:1119	arg1	heterodimerization					1121:1138	the first time TLR4/TLR2 heterodimerization	1096:1138	the first time TLR4/TLR2 heterodimerization that is induced by atypical LPS	1096:1170	This study reveals for the first time TLR4/TLR2 heterodimerization that is induced by atypical LPS and may help to escape from recognition by the innate immune system.
35140704	4	50	theme	Escherichia	662:672	arg1	LPS					679:681	Escherichia coli LPS	662:681	Escherichia coli LPS	662:681	In this study, we found that O. intermedium LPS exhibits a weak inflammatory activity compared to Escherichia coli LPS and, more importantly, is a specific TLR4/TLR2 agonist, able to signal through both receptors.
35140704	3	51	theme	atypical	550:557	arg1	LPS					559:561	an atypical LPS	547:561	an atypical LPS	547:561	Ochrobactrum intermedium, an opportunistic pathogen, presents an atypical LPS.
35140704	4	52	dep	Escherichia	662:672	arg1	coli					674:677	coli	674:677	coli	674:677	In this study, we found that O. intermedium LPS exhibits a weak inflammatory activity compared to Escherichia coli LPS and, more importantly, is a specific TLR4/TLR2 agonist, able to signal through both receptors.
35140704	1	53	theme	differentiation	132:146	arg1	complex					165:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex	92:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex	92:171	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex is considered the major receptor of the innate immune system to recognize lipopolysaccharides (LPSs).
35140704	0	54	theme	Endotoxic	68:76	arg1	LPS					87:89	Low Endotoxic Atypical LPS	64:89	Low Endotoxic Atypical LPS	64:89	Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS.
35140704	5	55	theme	LPS	823:825	arg1	analysis					796:803	Molecular docking analysis	778:803	Molecular docking analysis of O. intermedium LPS	778:825	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	2	56	theme	saccharide	335:344	arg1	moiety					346:351	core saccharide moiety	330:351	core saccharide moiety	330:351	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	3	57	theme	opportunistic	514:526	arg1	pathogen					528:535	an opportunistic pathogen	511:535	an opportunistic pathogen	511:535	Ochrobactrum intermedium, an opportunistic pathogen, presents an atypical LPS.
35140704	3	57	theme	opportunistic	514:526	arg1	intermedium					498:508	Ochrobactrum intermedium	485:508	Ochrobactrum intermedium	485:508	Ochrobactrum intermedium, an opportunistic pathogen, presents an atypical LPS.
35140704	1	58	theme	innate	213:218	arg1	system					227:232	the innate immune system	209:232	the innate immune system	209:232	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex is considered the major receptor of the innate immune system to recognize lipopolysaccharides (LPSs).
35140704	0	59	theme	Low	64:66	arg1	LPS					87:89	Low Endotoxic Atypical LPS	64:89	Low Endotoxic Atypical LPS	64:89	Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS.
35140704	4	60	theme	O.	593:594	arg1	LPS					608:610	O. intermedium LPS	593:610	O. intermedium LPS	593:610	In this study, we found that O. intermedium LPS exhibits a weak inflammatory activity compared to Escherichia coli LPS and, more importantly, is a specific TLR4/TLR2 agonist, able to signal through both receptors.
35140704	2	61	theme	core	330:333	arg1	moiety					346:351	core saccharide moiety	330:351	core saccharide moiety	330:351	However, some atypical LPSs with different lipid A and core saccharide moiety structures and compositions than the well-studied enterobacterial LPSs can induce a TLR2-dependent response in innate immune cells.
35140704	5	62	from	transfer	967:974	arg1	cells					986:990	cells	986:990	cells	986:990	Molecular docking analysis of O. intermedium LPS predicts a favorable formation of a TLR2/TLR4/MD-2 heterodimer complex, which was experimentally confirmed by fluorescence resonance energy transfer (FRET) in cells.
35140704	1	63	theme	immune	220:225	arg1	system					227:232	the innate immune system	209:232	the innate immune system	209:232	The Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex is considered the major receptor of the innate immune system to recognize lipopolysaccharides (LPSs).
32597437	10	0	from	EC/PNVPY	1668:1675	arg1	engineering					1723:1733	neural tissue engineering	1709:1733	neural tissue engineering	1709:1733	The findings suggest a positive outcome regarding the conductive polymer-modified EC/PNVPY and EC/P3HT nanofibrous mats in neural tissue engineering.
32597437	0	1	with	influence	95:103	arg1	stimulation					138:148	electrical stimulation	127:148	electrical stimulation for nerve tissue engineering	127:177	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	0	2	from	scaffolds	75:83	arg1	behavior					113:120	cell behavior	108:120	cell behavior	108:120	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	2	3	from	stimulation	345:355	arg1	polymers					371:378	conductive polymers	360:378	conductive polymers	360:378	Recently, electrical stimulation on conductive polymers has been applied to construct functional nerve cell scaffolds.
32597437	6	4	theme	higher	1141:1146	arg1	conductivity					1148:1159	higher conductivity	1141:1159	higher conductivity	1141:1159	Compared with pure EC mats, both the composite mats had increased thickness, higher porosity, and higher conductivity.
32597437	8	5	theme	favorable	1339:1347	arg1	activity					1354:1361	favorable cell activity	1339:1361	favorable cell activity	1339:1361	In vivo cytocompatibility of the undifferentiated PC12 cells showed that the EC/PNVPY and EC/P3HT scaffolds exhibited favorable cell activity, adhesion, and proliferation.
32597437	1	6	theme	nerve	285:289	arg1	adhesion					296:303	nerve cell adhesion	285:303	nerve cell adhesion	285:303	The fabrication of scaffolds with suitable chemical, physical, and electrical properties is critical for nerve cell adhesion and proliferation.
32597437	10	7	from	mats	1701:1704	arg1	engineering					1723:1733	neural tissue engineering	1709:1733	neural tissue engineering	1709:1733	The findings suggest a positive outcome regarding the conductive polymer-modified EC/PNVPY and EC/P3HT nanofibrous mats in neural tissue engineering.
32597437	6	8	theme	higher	1120:1125	arg1	porosity					1127:1134	higher porosity	1120:1134	higher porosity	1120:1134	Compared with pure EC mats, both the composite mats had increased thickness, higher porosity, and higher conductivity.
32597437	9	9	theme	electrical	1421:1430	arg1	experiments					1444:1454	electrical stimulation experiments	1421:1454	electrical stimulation experiments	1421:1454	Furthermore, the results of electrical stimulation experiments indicated that the EC/P3HT mats could effectively promote the proliferation of the PC12 cells more than the EC and EC/PNVPY mats.
32597437	8	10	theme	In	1221:1222	arg1	cytocompatibility					1229:1245	In vivo cytocompatibility	1221:1245	In vivo cytocompatibility of the undifferentiated PC12 cells	1221:1280	In vivo cytocompatibility of the undifferentiated PC12 cells showed that the EC/PNVPY and EC/P3HT scaffolds exhibited favorable cell activity, adhesion, and proliferation.
32597437	0	11	theme	electrical	127:136	arg1	stimulation					138:148	electrical stimulation	127:148	electrical stimulation for nerve tissue engineering	127:177	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	10	12	theme	neural	1709:1714	arg1	engineering					1723:1733	neural tissue engineering	1709:1733	neural tissue engineering	1709:1733	The findings suggest a positive outcome regarding the conductive polymer-modified EC/PNVPY and EC/P3HT nanofibrous mats in neural tissue engineering.
32597437	1	13	theme	chemical	223:230	arg1	properties					258:267	suitable chemical, physical, and electrical properties	214:267	suitable chemical, physical, and electrical properties	214:267	The fabrication of scaffolds with suitable chemical, physical, and electrical properties is critical for nerve cell adhesion and proliferation.
32597437	1	14	theme	physical	233:240	arg1	properties					258:267	suitable chemical, physical, and electrical properties	214:267	suitable chemical, physical, and electrical properties	214:267	The fabrication of scaffolds with suitable chemical, physical, and electrical properties is critical for nerve cell adhesion and proliferation.
32597437	6	15	contain	had	1095:1097	arg2	conductivity					1148:1159	higher conductivity	1141:1159	higher conductivity	1141:1159	Compared with pure EC mats, both the composite mats had increased thickness, higher porosity, and higher conductivity.
32597437	6	15	contain	had	1095:1097	arg1	mats					1090:1093	the composite mats	1076:1093	the composite mats	1076:1093	Compared with pure EC mats, both the composite mats had increased thickness, higher porosity, and higher conductivity.
32597437	6	15	contain	had	1095:1097	arg2	porosity					1127:1134	higher porosity	1120:1134	higher porosity	1120:1134	Compared with pure EC mats, both the composite mats had increased thickness, higher porosity, and higher conductivity.
32597437	6	15	contain	had	1095:1097	arg2	thickness					1109:1117	increased thickness	1099:1117	increased thickness	1099:1117	Compared with pure EC mats, both the composite mats had increased thickness, higher porosity, and higher conductivity.
32597437	0	16	theme	tissue	160:165	arg1	engineering					167:177	nerve tissue engineering	154:177	nerve tissue engineering	154:177	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	9	17	theme	EC/P3HT	1475:1481	arg1	mats					1483:1486	the EC/P3HT mats	1471:1486	the EC/P3HT mats	1471:1486	Furthermore, the results of electrical stimulation experiments indicated that the EC/P3HT mats could effectively promote the proliferation of the PC12 cells more than the EC and EC/PNVPY mats.
32597437	7	18	from	increase	1171:1178	arg1	hydrophilicity					1183:1196	hydrophilicity	1183:1196	hydrophilicity	1183:1196	Also, an increase in hydrophilicity was found for EC/P3HT.
32597437	8	19	theme	PC12	1271:1274	arg1	cells					1276:1280	the undifferentiated PC12 cells	1250:1280	the undifferentiated PC12 cells	1250:1280	In vivo cytocompatibility of the undifferentiated PC12 cells showed that the EC/PNVPY and EC/P3HT scaffolds exhibited favorable cell activity, adhesion, and proliferation.
32597437	5	20	theme	polymer	1025:1031	arg1	coatings					1033:1040	polymer coatings	1025:1040	polymer coatings	1025:1040	The OM and SEM images showed that PNVPY formed polymer coatings and aggregated nanoparticles on the EC nanofibers, while P3HT only produced polymer coatings.
32597437	4	21	theme	surface	682:688	arg1	immobilization					690:703	The surface immobilization	678:703	The surface immobilization	678:703	The surface immobilization was characterized by optical microscopy (OM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, hydrophilicity, porosity, and cyclic voltammetry.
32597437	4	22	theme	electron	760:767	arg1	SEM					781:783	SEM	781:783	SEM	781:783	The surface immobilization was characterized by optical microscopy (OM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, hydrophilicity, porosity, and cyclic voltammetry.
32597437	4	22	theme	electron	760:767	arg1	microscopy					769:778	scanning electron microscopy	751:778	scanning electron microscopy (SEM)	751:784	The surface immobilization was characterized by optical microscopy (OM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, hydrophilicity, porosity, and cyclic voltammetry.
32597437	3	23	dep	cellulose	546:554	arg1	i.e.					528:531	i.e.	528:531	i.e.	528:531	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	4	24	theme	optical	726:732	arg1	OM					746:747	OM	746:747	OM	746:747	The surface immobilization was characterized by optical microscopy (OM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, hydrophilicity, porosity, and cyclic voltammetry.
32597437	4	24	theme	optical	726:732	arg1	microscopy					734:743	optical microscopy	726:743	optical microscopy (OM)	726:748	The surface immobilization was characterized by optical microscopy (OM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, hydrophilicity, porosity, and cyclic voltammetry.
32597437	5	25	dep	OM	889:890	arg1	The					885:887	The	885:887	The	885:887	The OM and SEM images showed that PNVPY formed polymer coatings and aggregated nanoparticles on the EC nanofibers, while P3HT only produced polymer coatings.
32597437	2	26	theme	cell	427:430	arg1	scaffolds					432:440	functional nerve cell scaffolds	410:440	functional nerve cell scaffolds	410:440	Recently, electrical stimulation on conductive polymers has been applied to construct functional nerve cell scaffolds.
32597437	5	27	theme	aggregated	953:962	arg1	nanoparticles					964:976	aggregated nanoparticles	953:976	aggregated nanoparticles	953:976	The OM and SEM images showed that PNVPY formed polymer coatings and aggregated nanoparticles on the EC nanofibers, while P3HT only produced polymer coatings.
32597437	6	28	dep	Compared	1043:1050	arg1	both					1071:1074	both	1071:1074	both	1071:1074	Compared with pure EC mats, both the composite mats had increased thickness, higher porosity, and higher conductivity.
32597437	2	29	theme	functional	410:419	arg1	scaffolds					432:440	functional nerve cell scaffolds	410:440	functional nerve cell scaffolds	410:440	Recently, electrical stimulation on conductive polymers has been applied to construct functional nerve cell scaffolds.
32597437	0	30	theme	Electrospun	0:10	arg1	mats					59:62	Electrospun cellulose-based conductive polymer nanofibrous mats	0:62	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.	0:178	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	1	31	theme	cell	291:294	arg1	adhesion					296:303	nerve cell adhesion	285:303	nerve cell adhesion	285:303	The fabrication of scaffolds with suitable chemical, physical, and electrical properties is critical for nerve cell adhesion and proliferation.
32597437	0	32	theme	conductive	28:37	arg1	mats					59:62	Electrospun cellulose-based conductive polymer nanofibrous mats	0:62	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.	0:178	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	9	33	theme	EC	1564:1565	arg1	mats					1580:1583	the EC and EC/PNVPY mats	1560:1583	the EC and EC/PNVPY mats	1560:1583	Furthermore, the results of electrical stimulation experiments indicated that the EC/P3HT mats could effectively promote the proliferation of the PC12 cells more than the EC and EC/PNVPY mats.
32597437	3	34	theme	in	647:648	arg1	method					670:675	an efficient in situ polymerization method	634:675	an efficient in situ polymerization method	634:675	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	4	35	theme	infrared	805:812	arg1	spectroscopy					821:832	infrared (FTIR) spectroscopy	805:832	infrared (FTIR) spectroscopy	805:832	The surface immobilization was characterized by optical microscopy (OM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, hydrophilicity, porosity, and cyclic voltammetry.
32597437	10	36	theme	polymer-modified	1651:1666	arg1	EC/PNVPY					1668:1675	conductive polymer-modified EC/PNVPY	1640:1675	conductive polymer-modified EC/PNVPY	1640:1675	The findings suggest a positive outcome regarding the conductive polymer-modified EC/PNVPY and EC/P3HT nanofibrous mats in neural tissue engineering.
32597437	0	37	theme	nanofibrous	47:57	arg1	mats					59:62	Electrospun cellulose-based conductive polymer nanofibrous mats	0:62	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.	0:178	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	9	38	theme	EC/PNVPY	1571:1578	arg1	mats					1580:1583	the EC and EC/PNVPY mats	1560:1583	the EC and EC/PNVPY mats	1560:1583	Furthermore, the results of electrical stimulation experiments indicated that the EC/P3HT mats could effectively promote the proliferation of the PC12 cells more than the EC and EC/PNVPY mats.
32597437	10	39	theme	nanofibrous	1689:1699	arg1	mats					1701:1704	EC/P3HT nanofibrous mats	1681:1704	EC/P3HT nanofibrous mats	1681:1704	The findings suggest a positive outcome regarding the conductive polymer-modified EC/PNVPY and EC/P3HT nanofibrous mats in neural tissue engineering.
32597437	3	40	theme	polymerization	655:668	arg1	method					670:675	an efficient in situ polymerization method	634:675	an efficient in situ polymerization method	634:675	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	3	41	theme	electrospun	534:544	arg1	PNVPY					582:586	PNVPY	582:586	PNVPY	582:586	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	3	41	theme	electrospun	534:544	arg1	EC					557:558	EC	557:558	EC	557:558	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	3	41	theme	electrospun	534:544	arg1	cellulose					546:554	electrospun cellulose	534:554	electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY)	534:587	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	1	42	theme	electrical	247:256	arg1	properties					258:267	suitable chemical, physical, and electrical properties	214:267	suitable chemical, physical, and electrical properties	214:267	The fabrication of scaffolds with suitable chemical, physical, and electrical properties is critical for nerve cell adhesion and proliferation.
32597437	5	43	theme	EC	985:986	arg1	nanofibers					988:997	the EC nanofibers	981:997	the EC nanofibers	981:997	The OM and SEM images showed that PNVPY formed polymer coatings and aggregated nanoparticles on the EC nanofibers, while P3HT only produced polymer coatings.
32597437	10	44	theme	tissue	1716:1721	arg1	engineering					1723:1733	neural tissue engineering	1709:1733	neural tissue engineering	1709:1733	The findings suggest a positive outcome regarding the conductive polymer-modified EC/PNVPY and EC/P3HT nanofibrous mats in neural tissue engineering.
32597437	6	45	theme	EC	1062:1063	arg1	mats					1065:1068	pure EC mats	1057:1068	pure EC mats	1057:1068	Compared with pure EC mats, both the composite mats had increased thickness, higher porosity, and higher conductivity.
32597437	0	46	with	scaffolds	75:83	arg1	stimulation					138:148	electrical stimulation	127:148	electrical stimulation for nerve tissue engineering	127:177	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	4	47	dep	Fourier	787:793	arg1	transform					795:803	transform	795:803	transform infrared (FTIR) spectroscopy	795:832	The surface immobilization was characterized by optical microscopy (OM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, hydrophilicity, porosity, and cyclic voltammetry.
32597437	2	48	theme	electrical	334:343	arg1	stimulation					345:355	electrical stimulation	334:355	electrical stimulation on conductive polymers	334:378	Recently, electrical stimulation on conductive polymers has been applied to construct functional nerve cell scaffolds.
32597437	1	49	theme	scaffolds	199:207	arg1	critical					272:279	critical	272:279	critical	272:279	The fabrication of scaffolds with suitable chemical, physical, and electrical properties is critical for nerve cell adhesion and proliferation.
32597437	1	49	theme	scaffolds	199:207	arg1	fabrication					184:194	The fabrication	180:194	The fabrication of scaffolds with suitable chemical, physical, and electrical properties	180:267	The fabrication of scaffolds with suitable chemical, physical, and electrical properties is critical for nerve cell adhesion and proliferation.
32597437	3	50	theme	N-vinylpyrrole	566:579	arg1	PNVPY					582:586	PNVPY	582:586	PNVPY	582:586	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	3	50	theme	N-vinylpyrrole	566:579	arg1	EC					557:558	EC	557:558	EC	557:558	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	3	50	theme	N-vinylpyrrole	566:579	arg1	cellulose					546:554	electrospun cellulose	534:554	electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY)	534:587	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	9	51	theme	stimulation	1432:1442	arg1	experiments					1444:1454	electrical stimulation experiments	1421:1454	electrical stimulation experiments	1421:1454	Furthermore, the results of electrical stimulation experiments indicated that the EC/P3HT mats could effectively promote the proliferation of the PC12 cells more than the EC and EC/PNVPY mats.
32597437	0	52	from	influence	95:103	arg1	behavior					113:120	cell behavior	108:120	cell behavior	108:120	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	6	53	theme	increased	1099:1107	arg1	thickness					1109:1117	increased thickness	1099:1117	increased thickness	1099:1117	Compared with pure EC mats, both the composite mats had increased thickness, higher porosity, and higher conductivity.
32597437	0	54	theme	nerve	154:158	arg1	engineering					167:177	nerve tissue engineering	154:177	nerve tissue engineering	154:177	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	4	55	dep	infrared	805:812	arg1	FTIR					815:818	FTIR	815:818	FTIR	815:818	The surface immobilization was characterized by optical microscopy (OM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, hydrophilicity, porosity, and cyclic voltammetry.
32597437	5	56	theme	OM	889:890	arg1	images					900:905	The OM and SEM images	885:905	The OM and SEM images	885:905	The OM and SEM images showed that PNVPY formed polymer coatings and aggregated nanoparticles on the EC nanofibers, while P3HT only produced polymer coatings.
32597437	4	57	theme	cyclic	865:870	arg1	voltammetry					872:882	cyclic voltammetry	865:882	cyclic voltammetry	865:882	The surface immobilization was characterized by optical microscopy (OM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, hydrophilicity, porosity, and cyclic voltammetry.
32597437	5	58	theme	SEM	896:898	arg1	images					900:905	The OM and SEM images	885:905	The OM and SEM images	885:905	The OM and SEM images showed that PNVPY formed polymer coatings and aggregated nanoparticles on the EC nanofibers, while P3HT only produced polymer coatings.
32597437	8	59	theme	undifferentiated	1254:1269	arg1	cells					1276:1280	the undifferentiated PC12 cells	1250:1280	the undifferentiated PC12 cells	1250:1280	In vivo cytocompatibility of the undifferentiated PC12 cells showed that the EC/PNVPY and EC/P3HT scaffolds exhibited favorable cell activity, adhesion, and proliferation.
32597437	3	60	theme	polymer	502:508	arg1	mats					522:525	natural polymer (cellulose)/conductive polymer nanofibrous mats	463:525	natural polymer (cellulose)/conductive polymer nanofibrous mats	463:525	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	1	61	theme	suitable	214:221	arg1	properties					258:267	suitable chemical, physical, and electrical properties	214:267	suitable chemical, physical, and electrical properties	214:267	The fabrication of scaffolds with suitable chemical, physical, and electrical properties is critical for nerve cell adhesion and proliferation.
32597437	8	62	theme	cells	1276:1280	arg1	cytocompatibility					1229:1245	In vivo cytocompatibility	1221:1245	In vivo cytocompatibility of the undifferentiated PC12 cells	1221:1280	In vivo cytocompatibility of the undifferentiated PC12 cells showed that the EC/PNVPY and EC/P3HT scaffolds exhibited favorable cell activity, adhesion, and proliferation.
32597437	0	63	theme	cell	108:111	arg1	behavior					113:120	cell behavior	108:120	cell behavior	108:120	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	5	64	theme	polymer	932:938	arg1	coatings					940:947	polymer coatings	932:947	polymer coatings	932:947	The OM and SEM images showed that PNVPY formed polymer coatings and aggregated nanoparticles on the EC nanofibers, while P3HT only produced polymer coatings.
32597437	4	65	theme	scanning	751:758	arg1	SEM					781:783	SEM	781:783	SEM	781:783	The surface immobilization was characterized by optical microscopy (OM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, hydrophilicity, porosity, and cyclic voltammetry.
32597437	4	65	theme	scanning	751:758	arg1	microscopy					769:778	scanning electron microscopy	751:778	scanning electron microscopy (SEM)	751:784	The surface immobilization was characterized by optical microscopy (OM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, hydrophilicity, porosity, and cyclic voltammetry.
32597437	8	66	theme	EC/PNVPY	1298:1305	arg1	scaffolds					1319:1327	the EC/PNVPY and EC/P3HT scaffolds	1294:1327	the EC/PNVPY and EC/P3HT scaffolds	1294:1327	In vivo cytocompatibility of the undifferentiated PC12 cells showed that the EC/PNVPY and EC/P3HT scaffolds exhibited favorable cell activity, adhesion, and proliferation.
32597437	3	67	theme	nanofibrous	510:520	arg1	mats					522:525	natural polymer (cellulose)/conductive polymer nanofibrous mats	463:525	natural polymer (cellulose)/conductive polymer nanofibrous mats	463:525	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	9	68	theme	experiments	1444:1454	arg1	results					1410:1416	the results	1406:1416	the results of electrical stimulation experiments	1406:1454	Furthermore, the results of electrical stimulation experiments indicated that the EC/P3HT mats could effectively promote the proliferation of the PC12 cells more than the EC and EC/PNVPY mats.
32597437	8	69	dep	In	1221:1222	arg1	vivo					1224:1227	vivo	1224:1227	vivo	1224:1227	In vivo cytocompatibility of the undifferentiated PC12 cells showed that the EC/PNVPY and EC/P3HT scaffolds exhibited favorable cell activity, adhesion, and proliferation.
32597437	6	70	theme	pure	1057:1060	arg1	mats					1065:1068	pure EC mats	1057:1068	pure EC mats	1057:1068	Compared with pure EC mats, both the composite mats had increased thickness, higher porosity, and higher conductivity.
32597437	8	71	theme	EC/P3HT	1311:1317	arg1	scaffolds					1319:1327	the EC/PNVPY and EC/P3HT scaffolds	1294:1327	the EC/PNVPY and EC/P3HT scaffolds	1294:1327	In vivo cytocompatibility of the undifferentiated PC12 cells showed that the EC/PNVPY and EC/P3HT scaffolds exhibited favorable cell activity, adhesion, and proliferation.
32597437	2	72	theme	nerve	421:425	arg1	scaffolds					432:440	functional nerve cell scaffolds	410:440	functional nerve cell scaffolds	410:440	Recently, electrical stimulation on conductive polymers has been applied to construct functional nerve cell scaffolds.
32597437	0	73	theme	cellulose-based	12:26	arg1	mats					59:62	Electrospun cellulose-based conductive polymer nanofibrous mats	0:62	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.	0:178	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	10	74	theme	positive	1609:1616	arg1	outcome					1618:1624	a positive outcome	1607:1624	a positive outcome regarding the conductive polymer-modified EC/PNVPY and EC/P3HT nanofibrous mats in neural tissue engineering	1607:1733	The findings suggest a positive outcome regarding the conductive polymer-modified EC/PNVPY and EC/P3HT nanofibrous mats in neural tissue engineering.
32597437	0	75	theme	polymer	39:45	arg1	mats					59:62	Electrospun cellulose-based conductive polymer nanofibrous mats	0:62	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.	0:178	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	10	76	theme	conductive	1640:1649	arg1	EC/PNVPY					1668:1675	conductive polymer-modified EC/PNVPY	1640:1675	conductive polymer-modified EC/PNVPY	1640:1675	The findings suggest a positive outcome regarding the conductive polymer-modified EC/PNVPY and EC/P3HT nanofibrous mats in neural tissue engineering.
32597437	9	77	theme	PC12	1539:1542	arg1	cells					1544:1548	the PC12 cells	1535:1548	the PC12 cells	1535:1548	Furthermore, the results of electrical stimulation experiments indicated that the EC/P3HT mats could effectively promote the proliferation of the PC12 cells more than the EC and EC/PNVPY mats.
32597437	3	78	theme	efficient	637:645	arg1	method					670:675	an efficient in situ polymerization method	634:675	an efficient in situ polymerization method	634:675	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	8	79	theme	cell	1349:1352	arg1	activity					1354:1361	favorable cell activity	1339:1361	favorable cell activity	1339:1361	In vivo cytocompatibility of the undifferentiated PC12 cells showed that the EC/PNVPY and EC/P3HT scaffolds exhibited favorable cell activity, adhesion, and proliferation.
32597437	3	80	theme	/conductive	490:500	arg1	mats					522:525	natural polymer (cellulose)/conductive polymer nanofibrous mats	463:525	natural polymer (cellulose)/conductive polymer nanofibrous mats	463:525	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	3	81	theme	natural	463:469	arg1	mats					522:525	natural polymer (cellulose)/conductive polymer nanofibrous mats	463:525	natural polymer (cellulose)/conductive polymer nanofibrous mats	463:525	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	3	82	theme	cellulose	480:488	arg1	mats					522:525	natural polymer (cellulose)/conductive polymer nanofibrous mats	463:525	natural polymer (cellulose)/conductive polymer nanofibrous mats	463:525	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	0	83	theme	composite	65:73	arg1	scaffolds					75:83	composite scaffolds	65:83	composite scaffolds	65:83	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	1	84	with	scaffolds	199:207	arg1	properties					258:267	suitable chemical, physical, and electrical properties	214:267	suitable chemical, physical, and electrical properties	214:267	The fabrication of scaffolds with suitable chemical, physical, and electrical properties is critical for nerve cell adhesion and proliferation.
32597437	0	85	dep	mats	59:62	arg1	scaffolds					75:83	composite scaffolds	65:83	composite scaffolds	65:83	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	0	85	dep	mats	59:62	arg1	influence					95:103	their influence	89:103	their influence on cell behavior with electrical stimulation for nerve tissue engineering	89:177	Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering.
32597437	10	86	dep	EC/PNVPY	1668:1675	arg1	the					1636:1638	the	1636:1638	the	1636:1638	The findings suggest a positive outcome regarding the conductive polymer-modified EC/PNVPY and EC/P3HT nanofibrous mats in neural tissue engineering.
32597437	2	87	theme	conductive	360:369	arg1	polymers					371:378	conductive polymers	360:378	conductive polymers	360:378	Recently, electrical stimulation on conductive polymers has been applied to construct functional nerve cell scaffolds.
32597437	6	88	theme	composite	1080:1088	arg1	mats					1090:1093	the composite mats	1076:1093	the composite mats	1076:1093	Compared with pure EC mats, both the composite mats had increased thickness, higher porosity, and higher conductivity.
32597437	9	89	theme	cells	1544:1548	arg1	proliferation					1518:1530	the proliferation	1514:1530	the proliferation of the PC12 cells	1514:1548	Furthermore, the results of electrical stimulation experiments indicated that the EC/P3HT mats could effectively promote the proliferation of the PC12 cells more than the EC and EC/PNVPY mats.
32597437	10	90	theme	EC/P3HT	1681:1687	arg1	mats					1701:1704	EC/P3HT nanofibrous mats	1681:1704	EC/P3HT nanofibrous mats	1681:1704	The findings suggest a positive outcome regarding the conductive polymer-modified EC/PNVPY and EC/P3HT nanofibrous mats in neural tissue engineering.
32597437	3	91	theme	polymer	471:477	arg1	mats					522:525	natural polymer (cellulose)/conductive polymer nanofibrous mats	463:525	natural polymer (cellulose)/conductive polymer nanofibrous mats	463:525	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
32597437	3	92	dep	in	647:648	arg1	situ					650:653	situ	650:653	situ	650:653	Herein, we prepared natural polymer (cellulose)/conductive polymer nanofibrous mats, i.e., electrospun cellulose (EC)/poly N-vinylpyrrole (PNVPY) and EC/poly(3-hexylthiophene) (P3HT) through an efficient in situ polymerization method.
33323027	10	0	with	hydrogel	1530:1537	arg1	%					1546:1546	50%	1544:1546	50%	1544:1546	By examining the properties of hydrogels at different concentrations of calcium and phosphorus salts, we find that the CS-MA/SA-SH hydrogel with 50% (wt.
33323027	8	1	with	hydrogel	1170:1177	arg1	ability					1199:1205	a self-healing ability	1184:1205	a self-healing ability	1184:1205	It is worth noting that external Ca2+ can react with the residual carboxyl groups of SA and provide the hydrogel with a self-healing ability.
33323027	16	2	theme	Impact	2271:2276	arg1	statement					2278:2286	Impact statement	2271:2286	Impact statement	2271:2286	Impact statement In this article, we report a simple, gentle, and rapid method for the synthesis of new, in situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents.
33323027	21	3	theme	tooth	3671:3675	arg1	hardness					3677:3684	tooth hardness	3671:3684	tooth hardness	3671:3684	Comparison of commercial hydrogels further proves that this polysaccharide-based hydrogel is not only convenient for clinical operation in oral prosthesis but also has obvious advantages in the sealing of enamel by dental tubules and the enhancement of tooth hardness.
33323027	20	4	theme	dental	3402:3407	arg1	clinics					3409:3415	Chinese dental clinics	3394:3415	Chinese dental clinics	3394:3415	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	6	5	theme	calcium	860:866	arg1	phosphate					868:876	β-glycerophosphate calcium phosphate	841:876	β-glycerophosphate calcium phosphate	841:876	To endue its mineralize ability, β-glycerophosphate calcium phosphate and calcium carbonate as the precursor of hydroxyapatite (HAp) were premixed in the hydrogel at certain ratios.
33323027	20	6	theme	mineralization	3267:3280	arg1	regeneration					3282:3293	mineralization regeneration	3267:3293	mineralization regeneration of enamel and dentin	3267:3314	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	20	7	theme	in	3204:3205	arg1	ability					3228:3234	in vitro mineralization ability	3204:3234	in vitro mineralization ability	3204:3234	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	10	8	theme	phosphorus	1483:1492	arg1	salts					1494:1498	calcium and phosphorus salts	1471:1498	calcium and phosphorus salts	1471:1498	By examining the properties of hydrogels at different concentrations of calcium and phosphorus salts, we find that the CS-MA/SA-SH hydrogel with 50% (wt.
33323027	5	9	theme	Michael	645:651	arg1	addition					653:660	Michael addition	645:660	a rapid and facile Michael addition reaction	626:669	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	19	10	from	rich	2934:2937	arg1	calcium					2942:2948	calcium glycerophosphate	2942:2965	calcium glycerophosphate	2942:2965	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	19	10	from	rich	2934:2937	arg1	chloride					2979:2986	calcium chloride	2971:2986	calcium chloride	2971:2986	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	17	11	theme	calcium	2625:2631	arg1	ions					2633:2636	calcium ions	2625:2636	calcium ions	2625:2636	The rapid healing ability of the hydrogel can be obtained within 1 min by introducing calcium ions, giving the hydrogel the possibility of self-healing in the cap-enriched state.
33323027	10	12	theme	calcium	1471:1477	arg1	salts					1494:1498	calcium and phosphorus salts	1471:1498	calcium and phosphorus salts	1471:1498	By examining the properties of hydrogels at different concentrations of calcium and phosphorus salts, we find that the CS-MA/SA-SH hydrogel with 50% (wt.
33323027	16	13	dep	addition	2472:2479	arg1	reaction					2481:2488	reaction	2481:2488	the Michael addition reaction	2460:2488	Impact statement In this article, we report a simple, gentle, and rapid method for the synthesis of new, in situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents.
33323027	18	14	used	used	2780:2783	arg2	we					2726:2727	we	2726:2727	we	2726:2727	Second, we conferred in vitro mineralization of hydrogels and used a simple novel "enzyme-promoted" approach.
33323027	10	15	dep	find	1504:1507	arg1	hydrogel					1530:1537	the CS-MA/SA-SH hydrogel	1514:1537	the CS-MA/SA-SH hydrogel with 50% (wt	1514:1550	By examining the properties of hydrogels at different concentrations of calcium and phosphorus salts, we find that the CS-MA/SA-SH hydrogel with 50% (wt.
33323027	19	16	theme	body	3056:3059	arg1	environment					3067:3077	a simulated body fluid environment	3044:3077	a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products	3044:3154	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	8	17	theme	carboxyl	1132:1139	arg1	SA					1151:1152	SA	1151:1152	SA	1151:1152	It is worth noting that external Ca2+ can react with the residual carboxyl groups of SA and provide the hydrogel with a self-healing ability.
33323027	8	17	theme	carboxyl	1132:1139	arg1	groups					1141:1146	the residual carboxyl groups	1119:1146	the residual carboxyl groups of SA	1119:1152	It is worth noting that external Ca2+ can react with the residual carboxyl groups of SA and provide the hydrogel with a self-healing ability.
33323027	17	18	theme	healing	2549:2555	arg1	ability					2557:2563	The rapid healing ability	2539:2563	The rapid healing ability of the hydrogel	2539:2579	The rapid healing ability of the hydrogel can be obtained within 1 min by introducing calcium ions, giving the hydrogel the possibility of self-healing in the cap-enriched state.
33323027	21	19	theme	polysaccharide-based	3478:3497	arg1	hydrogel					3499:3506	this polysaccharide-based hydrogel	3473:3506	this polysaccharide-based hydrogel	3473:3506	Comparison of commercial hydrogels further proves that this polysaccharide-based hydrogel is not only convenient for clinical operation in oral prosthesis but also has obvious advantages in the sealing of enamel by dental tubules and the enhancement of tooth hardness.
33323027	8	20	theme	self-healing	1186:1197	arg1	ability					1199:1205	a self-healing ability	1184:1205	a self-healing ability	1184:1205	It is worth noting that external Ca2+ can react with the residual carboxyl groups of SA and provide the hydrogel with a self-healing ability.
33323027	11	21	theme	ideal	1677:1681	arg1	compatibility					1688:1700	ideal cell compatibility	1677:1700	ideal cell compatibility	1677:1700	%) inorganic matter presented the best self-healing properties, excellent mineralization of highly crystallized Hap, and has ideal cell compatibility.
33323027	5	22	theme	maleic	684:689	arg1	[MA					721:723	CS-maleic anhydride [MA]	701:724	CS-maleic anhydride [MA]	701:724	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	5	22	theme	maleic	684:689	arg1	chitosan					691:698	maleic chitosan	684:698	maleic chitosan (CS-maleic anhydride [MA])	684:725	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	18	23	theme	"	2816:2816	arg1	approach					2818:2825	a simple novel "enzyme-promoted" approach	2785:2825	a simple novel "enzyme-promoted" approach	2785:2825	Second, we conferred in vitro mineralization of hydrogels and used a simple novel "enzyme-promoted" approach.
33323027	9	24	theme	hard	1378:1381	arg1	tissue					1383:1388	regenerating hard tissue	1365:1388	regenerating hard tissue	1365:1388	At the same time, we creatively propose a method that uses alkaline phosphatase to promote the mineralization of HAp in hydrogels, to achieve the purpose of regenerating hard tissue in situ.
33323027	12	25	theme	dental	1852:1857	arg1	experiments					1871:1881	preliminary in vitro dental restoration experiments	1831:1881	preliminary in vitro dental restoration experiments	1831:1881	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth was explored through preliminary in vitro dental restoration experiments.
33323027	7	26	theme	hydrogel	1003:1010	arg1	kind					995:998	This kind	990:998	This kind of hydrogel	990:1010	This kind of hydrogel can quickly form into different shapes within 10 min.
33323027	2	27	theme	repair	218:223	arg1	defects					238:244	repair narrow tooth defects	218:244	repair narrow tooth defects	218:244	At present, photocrosslinking resin is commonly used in clinics to repair narrow tooth defects, but the ultraviolet light used in this process has unavoidable cytotoxicity.
33323027	17	28	theme	hydrogel	2572:2579	arg1	ability					2557:2563	The rapid healing ability	2539:2563	The rapid healing ability of the hydrogel	2539:2579	The rapid healing ability of the hydrogel can be obtained within 1 min by introducing calcium ions, giving the hydrogel the possibility of self-healing in the cap-enriched state.
33323027	14	29	theme	local	2047:2051	arg1	environment					2053:2063	the local environment	2043:2063	the local environment	2043:2063	In addition, the HAp morphology was affected by the local environment.
33323027	21	30	theme	commercial	3432:3441	arg1	hydrogels					3443:3451	commercial hydrogels	3432:3451	commercial hydrogels	3432:3451	Comparison of commercial hydrogels further proves that this polysaccharide-based hydrogel is not only convenient for clinical operation in oral prosthesis but also has obvious advantages in the sealing of enamel by dental tubules and the enhancement of tooth hardness.
33323027	21	31	from	operation	3544:3552	arg1	prosthesis					3562:3571	oral prosthesis	3557:3571	oral prosthesis	3557:3571	Comparison of commercial hydrogels further proves that this polysaccharide-based hydrogel is not only convenient for clinical operation in oral prosthesis but also has obvious advantages in the sealing of enamel by dental tubules and the enhancement of tooth hardness.
33323027	17	32	theme	cap-enriched	2698:2709	arg1	state					2711:2715	the cap-enriched state	2694:2715	the cap-enriched state	2694:2715	The rapid healing ability of the hydrogel can be obtained within 1 min by introducing calcium ions, giving the hydrogel the possibility of self-healing in the cap-enriched state.
33323027	0	33	theme	Hydrogels	56:64	arg1	Synthesis					7:15	Facile Synthesis	0:15	Facile Synthesis of In Situ Formable Alginate Composite Hydrogels with Ca2+-Induced Healing Ability.	0:99	Facile Synthesis of In Situ Formable Alginate Composite Hydrogels with Ca2+-Induced Healing Ability.
33323027	18	34	theme	hydrogels	2766:2774	arg1	mineralization					2748:2761	in vitro mineralization	2739:2761	in vitro mineralization of hydrogels	2739:2774	Second, we conferred in vitro mineralization of hydrogels and used a simple novel "enzyme-promoted" approach.
33323027	2	35	theme	tooth	232:236	arg1	defects					238:244	repair narrow tooth defects	218:244	repair narrow tooth defects	218:244	At present, photocrosslinking resin is commonly used in clinics to repair narrow tooth defects, but the ultraviolet light used in this process has unavoidable cytotoxicity.
33323027	20	36	theme	dentin	3309:3314	arg1	repair					3256:3261	simple repair	3249:3261	simple repair	3249:3261	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	20	36	theme	dentin	3309:3314	arg1	regeneration					3282:3293	mineralization regeneration	3267:3293	mineralization regeneration of enamel and dentin	3267:3314	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	16	37	theme	Michael	2464:2470	arg1	addition					2472:2479	the Michael addition reaction	2460:2488	the Michael addition reaction	2460:2488	Impact statement In this article, we report a simple, gentle, and rapid method for the synthesis of new, in situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents.
33323027	2	38	used	used	199:202	arg2	resin					181:185	photocrosslinking resin	163:185	photocrosslinking resin	163:185	At present, photocrosslinking resin is commonly used in clinics to repair narrow tooth defects, but the ultraviolet light used in this process has unavoidable cytotoxicity.
33323027	19	39	theme	body-enriched	2865:2877	arg1	phosphatase					2888:2898	human body-enriched alkaline phosphatase	2859:2898	human body-enriched alkaline phosphatase	2859:2898	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	19	39	theme	body-enriched	2865:2877	arg1	inducer					2906:2912	an inducer	2903:2912	an inducer	2903:2912	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	17	40	theme	rapid	2543:2547	arg1	ability					2557:2563	The rapid healing ability	2539:2563	The rapid healing ability of the hydrogel	2539:2579	The rapid healing ability of the hydrogel can be obtained within 1 min by introducing calcium ions, giving the hydrogel the possibility of self-healing in the cap-enriched state.
33323027	16	41	theme	new	2371:2373	arg1	synthesis					2358:2366	the synthesis	2354:2366	the synthesis of new	2354:2373	Impact statement In this article, we report a simple, gentle, and rapid method for the synthesis of new, in situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents.
33323027	0	42	theme	Ca2+-Induced	71:82	arg1	Ability					92:98	Ca2+-Induced Healing Ability	71:98	Ca2+-Induced Healing Ability	71:98	Facile Synthesis of In Situ Formable Alginate Composite Hydrogels with Ca2+-Induced Healing Ability.
33323027	9	43	theme	same	1215:1218	arg1	time					1220:1223	the same time	1211:1223	the same time	1211:1223	At the same time, we creatively propose a method that uses alkaline phosphatase to promote the mineralization of HAp in hydrogels, to achieve the purpose of regenerating hard tissue in situ.
33323027	10	44	dep	hydrogel	1530:1537	arg1	wt					1549:1550	wt	1549:1550	the CS-MA/SA-SH hydrogel with 50% (wt	1514:1550	By examining the properties of hydrogels at different concentrations of calcium and phosphorus salts, we find that the CS-MA/SA-SH hydrogel with 50% (wt.
33323027	20	45	theme	enamel	3298:3303	arg1	repair					3256:3261	simple repair	3249:3261	simple repair	3249:3261	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	20	45	theme	enamel	3298:3303	arg1	regeneration					3282:3293	mineralization regeneration	3267:3293	mineralization regeneration of enamel and dentin	3267:3314	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	19	46	theme	well-shaped	3110:3120	arg1	products					3147:3154	37°C, stone-structured, and well-shaped thin-section mineralized products	3082:3154	37°C, stone-structured, and well-shaped thin-section mineralized products	3082:3154	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	11	47	theme	Hap	1664:1666	arg1	properties					1604:1613	the best self-healing properties	1582:1613	the best self-healing properties	1582:1613	%) inorganic matter presented the best self-healing properties, excellent mineralization of highly crystallized Hap, and has ideal cell compatibility.
33323027	11	47	theme	Hap	1664:1666	arg1	mineralization					1626:1639	excellent mineralization	1616:1639	excellent mineralization of highly crystallized Hap	1616:1666	%) inorganic matter presented the best self-healing properties, excellent mineralization of highly crystallized Hap, and has ideal cell compatibility.
33323027	5	48	theme	anhydride	711:719	arg1	[MA					721:723	CS-maleic anhydride [MA]	701:724	CS-maleic anhydride [MA]	701:724	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	5	48	theme	anhydride	711:719	arg1	chitosan					691:698	maleic chitosan	684:698	maleic chitosan (CS-maleic anhydride [MA])	684:725	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	18	49	theme	simple	2787:2792	arg1	approach					2818:2825	a simple novel "enzyme-promoted" approach	2785:2825	a simple novel "enzyme-promoted" approach	2785:2825	Second, we conferred in vitro mineralization of hydrogels and used a simple novel "enzyme-promoted" approach.
33323027	12	50	theme	preliminary	1831:1841	arg1	experiments					1871:1881	preliminary in vitro dental restoration experiments	1831:1881	preliminary in vitro dental restoration experiments	1831:1881	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth was explored through preliminary in vitro dental restoration experiments.
33323027	20	51	dep	in	3204:3205	arg1	vitro					3207:3211	vitro	3207:3211	vitro	3207:3211	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	13	52	theme	commercial	1964:1973	arg1	sensitizers					1982:1992	commercial dental sensitizers	1964:1992	commercial dental sensitizers	1964:1992	Obviously, the penetration depth through dentin tubules was better than that of commercial dental sensitizers.
33323027	18	53	dep	in	2739:2740	arg1	vitro					2742:2746	vitro	2742:2746	vitro	2742:2746	Second, we conferred in vitro mineralization of hydrogels and used a simple novel "enzyme-promoted" approach.
33323027	19	54	theme	Simulated	2828:2836	arg1	mineralization					2838:2851	Simulated mineralization	2828:2851	Simulated mineralization	2828:2851	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	0	55	theme	Facile	0:5	arg1	Synthesis					7:15	Facile Synthesis	0:15	Facile Synthesis of In Situ Formable Alginate Composite Hydrogels with Ca2+-Induced Healing Ability.	0:99	Facile Synthesis of In Situ Formable Alginate Composite Hydrogels with Ca2+-Induced Healing Ability.
33323027	16	56	theme	situ-formable	2379:2391	arg1	hydrogels					2414:2422	situ-formable polysaccharide-based hydrogels	2379:2422	situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents	2379:2536	Impact statement In this article, we report a simple, gentle, and rapid method for the synthesis of new, in situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents.
33323027	3	57	theme	similar	349:355	arg1	structure					357:365	a similar structure	347:365	a similar structure to that of the natural extracellular matrix	347:409	In situ hydrogels with a similar structure to that of the natural extracellular matrix have gradually attracted attention in the field of hard tissue repair engineering.
33323027	16	58	theme	polysaccharide-based	2393:2412	arg1	hydrogels					2414:2422	situ-formable polysaccharide-based hydrogels	2379:2422	situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents	2379:2536	Impact statement In this article, we report a simple, gentle, and rapid method for the synthesis of new, in situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents.
33323027	20	59	theme	desensitizing	3357:3369	arg1	agent					3371:3375	the tooth desensitizing agent	3347:3375	the tooth desensitizing agent commonly used in Chinese dental clinics	3347:3415	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	19	60	from	hydroxyphospholipids	3020:3039	arg1	products					3147:3154	37°C, stone-structured, and well-shaped thin-section mineralized products	3082:3154	37°C, stone-structured, and well-shaped thin-section mineralized products	3082:3154	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	19	60	from	hydroxyphospholipids	3020:3039	arg1	environment					3067:3077	a simulated body fluid environment	3044:3077	a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products	3044:3154	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	3	61	theme	natural	382:388	arg1	matrix					404:409	the natural extracellular matrix	378:409	the natural extracellular matrix	378:409	In situ hydrogels with a similar structure to that of the natural extracellular matrix have gradually attracted attention in the field of hard tissue repair engineering.
33323027	2	62	theme	photocrosslinking	163:179	arg1	resin					181:185	photocrosslinking resin	163:185	photocrosslinking resin	163:185	At present, photocrosslinking resin is commonly used in clinics to repair narrow tooth defects, but the ultraviolet light used in this process has unavoidable cytotoxicity.
33323027	12	63	theme	restoration	1859:1869	arg1	experiments					1871:1881	preliminary in vitro dental restoration experiments	1831:1881	preliminary in vitro dental restoration experiments	1831:1881	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth was explored through preliminary in vitro dental restoration experiments.
33323027	21	64	theme	obvious	3586:3592	arg1	advantages					3594:3603	obvious advantages	3586:3603	obvious advantages	3586:3603	Comparison of commercial hydrogels further proves that this polysaccharide-based hydrogel is not only convenient for clinical operation in oral prosthesis but also has obvious advantages in the sealing of enamel by dental tubules and the enhancement of tooth hardness.
33323027	5	65	theme	sodium	751:756	arg1	-SH					771:773	sodium alginate [SA]-SH	751:773	sodium alginate [SA]-SH	751:773	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	5	65	theme	sodium	751:756	arg1	alginate					741:748	thiolated alginate	731:748	thiolated alginate (sodium alginate [SA]-SH)	731:774	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	9	66	theme	alkaline	1267:1274	arg1	phosphatase					1276:1286	alkaline phosphatase	1267:1286	alkaline phosphatase	1267:1286	At the same time, we creatively propose a method that uses alkaline phosphatase to promote the mineralization of HAp in hydrogels, to achieve the purpose of regenerating hard tissue in situ.
33323027	12	67	theme	dentin	1778:1783	arg1	tubules					1785:1791	exposed dentin tubules	1770:1791	exposed dentin tubules in decayed teeth	1770:1808	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth was explored through preliminary in vitro dental restoration experiments.
33323027	12	68	theme	potential	1707:1715	arg1	application					1717:1727	The potential application	1703:1727	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth	1703:1808	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth was explored through preliminary in vitro dental restoration experiments.
33323027	4	69	theme	molding	509:515	arg1	properties					517:526	The injectable molding properties	494:526	The injectable molding properties of hydrogel	494:538	The injectable molding properties of hydrogel also give it the potential to fill irregularly shaped or fine tissue defects.
33323027	10	70	theme	hydrogels	1430:1438	arg1	properties					1416:1425	the properties	1412:1425	the properties of hydrogels	1412:1438	By examining the properties of hydrogels at different concentrations of calcium and phosphorus salts, we find that the CS-MA/SA-SH hydrogel with 50% (wt.
33323027	3	71	theme	tissue	467:472	arg1	engineering					481:491	hard tissue repair engineering	462:491	hard tissue repair engineering	462:491	In situ hydrogels with a similar structure to that of the natural extracellular matrix have gradually attracted attention in the field of hard tissue repair engineering.
33323027	5	72	theme	[SA	767:769	arg1	-SH					771:773	sodium alginate [SA]-SH	751:773	sodium alginate [SA]-SH	751:773	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	5	72	theme	[SA	767:769	arg1	alginate					741:748	thiolated alginate	731:748	thiolated alginate (sodium alginate [SA]-SH)	731:774	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	11	73	theme	excellent	1616:1624	arg1	properties					1604:1613	the best self-healing properties	1582:1613	the best self-healing properties	1582:1613	%) inorganic matter presented the best self-healing properties, excellent mineralization of highly crystallized Hap, and has ideal cell compatibility.
33323027	11	73	theme	excellent	1616:1624	arg1	mineralization					1626:1639	excellent mineralization	1616:1639	excellent mineralization of highly crystallized Hap	1616:1666	%) inorganic matter presented the best self-healing properties, excellent mineralization of highly crystallized Hap, and has ideal cell compatibility.
33323027	16	74	theme	simple	2317:2322	arg1	method					2343:2348	a simple, gentle, and rapid method	2315:2348	a simple, gentle, and rapid method for the synthesis of new	2315:2373	Impact statement In this article, we report a simple, gentle, and rapid method for the synthesis of new, in situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents.
33323027	15	75	theme	tissue	2250:2255	arg1	regeneration					2257:2268	hard tissue regeneration	2245:2268	hard tissue regeneration	2245:2268	We believe that this hydrogel can utilize tissues for dental regeneration and mineralization, and the healing ability provides the hydrogel flexibility for further application in hard tissue regeneration.
33323027	9	76	from	mineralization	1303:1316	arg1	hydrogels					1328:1336	hydrogels	1328:1336	hydrogels	1328:1336	At the same time, we creatively propose a method that uses alkaline phosphatase to promote the mineralization of HAp in hydrogels, to achieve the purpose of regenerating hard tissue in situ.
33323027	16	77	theme	healing	2444:2450	arg1	capable					2433:2439	capable	2433:2439	capable	2433:2439	Impact statement In this article, we report a simple, gentle, and rapid method for the synthesis of new, in situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents.
33323027	4	78	theme	shaped	587:592	arg1	defects					609:615	irregularly shaped or fine tissue defects	575:615	irregularly shaped or fine tissue defects	575:615	The injectable molding properties of hydrogel also give it the potential to fill irregularly shaped or fine tissue defects.
33323027	16	79	theme	gentle	2325:2330	arg1	method					2343:2348	a simple, gentle, and rapid method	2315:2348	a simple, gentle, and rapid method for the synthesis of new	2315:2373	Impact statement In this article, we report a simple, gentle, and rapid method for the synthesis of new, in situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents.
33323027	0	80	theme	Composite	46:54	arg1	Hydrogels					56:64	In Situ Formable Alginate Composite Hydrogels	20:64	In Situ Formable Alginate Composite Hydrogels	20:64	Facile Synthesis of In Situ Formable Alginate Composite Hydrogels with Ca2+-Induced Healing Ability.
33323027	6	81	theme	calcium	882:888	arg1	carbonate					890:898	calcium carbonate	882:898	calcium carbonate	882:898	To endue its mineralize ability, β-glycerophosphate calcium phosphate and calcium carbonate as the precursor of hydroxyapatite (HAp) were premixed in the hydrogel at certain ratios.
33323027	4	82	theme	fine	597:600	arg1	defects					609:615	irregularly shaped or fine tissue defects	575:615	irregularly shaped or fine tissue defects	575:615	The injectable molding properties of hydrogel also give it the potential to fill irregularly shaped or fine tissue defects.
33323027	10	83	theme	different	1443:1451	arg1	concentrations					1453:1466	different concentrations	1443:1466	different concentrations of calcium and phosphorus salts	1443:1498	By examining the properties of hydrogels at different concentrations of calcium and phosphorus salts, we find that the CS-MA/SA-SH hydrogel with 50% (wt.
33323027	5	84	theme	thiolated	731:739	arg1	-SH					771:773	sodium alginate [SA]-SH	751:773	sodium alginate [SA]-SH	751:773	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	5	84	theme	thiolated	731:739	arg1	alginate					741:748	thiolated alginate	731:748	thiolated alginate (sodium alginate [SA]-SH)	731:774	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	5	85	theme	rapid	628:632	arg1	reaction					662:669	a rapid and facile Michael addition reaction	626:669	a rapid and facile Michael addition reaction	626:669	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	13	86	theme	dentin	1925:1930	arg1	tubules					1932:1938	dentin tubules	1925:1938	dentin tubules	1925:1938	Obviously, the penetration depth through dentin tubules was better than that of commercial dental sensitizers.
33323027	3	87	theme	engineering	481:491	arg1	field					453:457	the field	449:457	the field of hard tissue repair engineering	449:491	In situ hydrogels with a similar structure to that of the natural extracellular matrix have gradually attracted attention in the field of hard tissue repair engineering.
33323027	19	88	theme	glycerophosphate	2950:2965	arg1	calcium					2942:2948	calcium glycerophosphate	2942:2965	calcium glycerophosphate	2942:2965	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	15	89	theme	further	2222:2228	arg1	application					2230:2240	further application	2222:2240	further application in hard tissue regeneration	2222:2268	We believe that this hydrogel can utilize tissues for dental regeneration and mineralization, and the healing ability provides the hydrogel flexibility for further application in hard tissue regeneration.
33323027	20	90	theme	self-healing	3177:3188	arg1	hydrogel					3190:3197	the self-healing hydrogel	3173:3197	the self-healing hydrogel with in vitro mineralization ability	3173:3234	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	10	91	theme	salts	1494:1498	arg1	concentrations					1453:1466	different concentrations	1443:1466	different concentrations of calcium and phosphorus salts	1443:1498	By examining the properties of hydrogels at different concentrations of calcium and phosphorus salts, we find that the CS-MA/SA-SH hydrogel with 50% (wt.
33323027	5	92	theme	facile	638:643	arg1	reaction					662:669	a rapid and facile Michael addition reaction	626:669	a rapid and facile Michael addition reaction	626:669	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	19	93	theme	simulated	3046:3054	arg1	environment					3067:3077	a simulated body fluid environment	3044:3077	a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products	3044:3154	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	21	94	theme	hardness	3677:3684	arg1	enhancement					3656:3666	the enhancement	3652:3666	the enhancement of tooth hardness	3652:3684	Comparison of commercial hydrogels further proves that this polysaccharide-based hydrogel is not only convenient for clinical operation in oral prosthesis but also has obvious advantages in the sealing of enamel by dental tubules and the enhancement of tooth hardness.
33323027	8	95	theme	external	1090:1097	arg1	Ca2+					1099:1102	external Ca2+	1090:1102	external Ca2+	1090:1102	It is worth noting that external Ca2+ can react with the residual carboxyl groups of SA and provide the hydrogel with a self-healing ability.
33323027	6	96	theme	β-glycerophosphate	841:858	arg1	phosphate					868:876	β-glycerophosphate calcium phosphate	841:876	β-glycerophosphate calcium phosphate	841:876	To endue its mineralize ability, β-glycerophosphate calcium phosphate and calcium carbonate as the precursor of hydroxyapatite (HAp) were premixed in the hydrogel at certain ratios.
33323027	11	97	contain	has	1673:1675	arg1	matter					1565:1570	inorganic matter	1555:1570	inorganic matter	1555:1570	%) inorganic matter presented the best self-healing properties, excellent mineralization of highly crystallized Hap, and has ideal cell compatibility.
33323027	11	97	contain	has	1673:1675	arg2	compatibility					1688:1700	ideal cell compatibility	1677:1700	ideal cell compatibility	1677:1700	%) inorganic matter presented the best self-healing properties, excellent mineralization of highly crystallized Hap, and has ideal cell compatibility.
33323027	11	98	theme	inorganic	1555:1563	arg1	matter					1565:1570	inorganic matter	1555:1570	inorganic matter	1555:1570	%) inorganic matter presented the best self-healing properties, excellent mineralization of highly crystallized Hap, and has ideal cell compatibility.
33323027	7	99	theme	different	1034:1042	arg1	shapes					1044:1049	different shapes	1034:1049	different shapes	1034:1049	This kind of hydrogel can quickly form into different shapes within 10 min.
33323027	19	100	theme	mineralized	3135:3145	arg1	products					3147:3154	37°C, stone-structured, and well-shaped thin-section mineralized products	3082:3154	37°C, stone-structured, and well-shaped thin-section mineralized products	3082:3154	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	2	101	theme	ultraviolet	255:265	arg1	light					267:271	the ultraviolet light	251:271	the ultraviolet light used in this process	251:292	At present, photocrosslinking resin is commonly used in clinics to repair narrow tooth defects, but the ultraviolet light used in this process has unavoidable cytotoxicity.
33323027	21	102	theme	oral	3557:3560	arg1	prosthesis					3562:3571	oral prosthesis	3557:3571	oral prosthesis	3557:3571	Comparison of commercial hydrogels further proves that this polysaccharide-based hydrogel is not only convenient for clinical operation in oral prosthesis but also has obvious advantages in the sealing of enamel by dental tubules and the enhancement of tooth hardness.
33323027	0	103	theme	Alginate	37:44	arg1	Hydrogels					56:64	In Situ Formable Alginate Composite Hydrogels	20:64	In Situ Formable Alginate Composite Hydrogels	20:64	Facile Synthesis of In Situ Formable Alginate Composite Hydrogels with Ca2+-Induced Healing Ability.
33323027	20	104	theme	simple	3249:3254	arg1	repair					3256:3261	simple repair	3249:3261	simple repair	3249:3261	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	6	105	from	ratios	982:987	arg1	hydrogel					962:969	the hydrogel	958:969	the hydrogel at certain ratios	958:987	To endue its mineralize ability, β-glycerophosphate calcium phosphate and calcium carbonate as the precursor of hydroxyapatite (HAp) were premixed in the hydrogel at certain ratios.
33323027	12	106	from	tubules	1785:1791	arg1	teeth					1804:1808	decayed teeth	1796:1808	decayed teeth	1796:1808	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth was explored through preliminary in vitro dental restoration experiments.
33323027	19	107	theme	fluid	3061:3065	arg1	environment					3067:3077	a simulated body fluid environment	3044:3077	a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products	3044:3154	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	9	108	theme	regenerating	1365:1376	arg1	tissue					1383:1388	regenerating hard tissue	1365:1388	regenerating hard tissue	1365:1388	At the same time, we creatively propose a method that uses alkaline phosphatase to promote the mineralization of HAp in hydrogels, to achieve the purpose of regenerating hard tissue in situ.
33323027	8	109	theme	residual	1123:1130	arg1	SA					1151:1152	SA	1151:1152	SA	1151:1152	It is worth noting that external Ca2+ can react with the residual carboxyl groups of SA and provide the hydrogel with a self-healing ability.
33323027	8	109	theme	residual	1123:1130	arg1	groups					1141:1146	the residual carboxyl groups	1119:1146	the residual carboxyl groups of SA	1119:1152	It is worth noting that external Ca2+ can react with the residual carboxyl groups of SA and provide the hydrogel with a self-healing ability.
33323027	6	110	theme	hydroxyapatite	920:933	arg1	precursor					907:915	the precursor	903:915	the precursor of hydroxyapatite (HAp)	903:939	To endue its mineralize ability, β-glycerophosphate calcium phosphate and calcium carbonate as the precursor of hydroxyapatite (HAp) were premixed in the hydrogel at certain ratios.
33323027	19	111	theme	calcium	2971:2977	arg1	chloride					2979:2986	calcium chloride	2971:2986	calcium chloride	2971:2986	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	12	112	dep	in	1843:1844	arg1	vitro					1846:1850	vitro	1846:1850	vitro	1846:1850	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth was explored through preliminary in vitro dental restoration experiments.
33323027	11	113	theme	cell	1683:1686	arg1	compatibility					1688:1700	ideal cell compatibility	1677:1700	ideal cell compatibility	1677:1700	%) inorganic matter presented the best self-healing properties, excellent mineralization of highly crystallized Hap, and has ideal cell compatibility.
33323027	18	114	theme	enzyme-promoted	2801:2815	arg1	approach					2818:2825	a simple novel "enzyme-promoted" approach	2785:2825	a simple novel "enzyme-promoted" approach	2785:2825	Second, we conferred in vitro mineralization of hydrogels and used a simple novel "enzyme-promoted" approach.
33323027	2	115	theme	narrow	225:230	arg1	defects					238:244	repair narrow tooth defects	218:244	repair narrow tooth defects	218:244	At present, photocrosslinking resin is commonly used in clinics to repair narrow tooth defects, but the ultraviolet light used in this process has unavoidable cytotoxicity.
33323027	5	116	theme	CS-MA/SA-SH	786:796	arg1	hydrogel					798:805	a CS-MA/SA-SH hydrogel	784:805	a CS-MA/SA-SH hydrogel	784:805	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	15	117	from	application	2230:2240	arg1	regeneration					2257:2268	hard tissue regeneration	2245:2268	hard tissue regeneration	2245:2268	We believe that this hydrogel can utilize tissues for dental regeneration and mineralization, and the healing ability provides the hydrogel flexibility for further application in hard tissue regeneration.
33323027	3	118	with	hydrogels	332:340	arg1	structure					357:365	a similar structure	347:365	a similar structure to that of the natural extracellular matrix	347:409	In situ hydrogels with a similar structure to that of the natural extracellular matrix have gradually attracted attention in the field of hard tissue repair engineering.
33323027	21	119	theme	dental	3633:3638	arg1	tubules					3640:3646	dental tubules	3633:3646	dental tubules	3633:3646	Comparison of commercial hydrogels further proves that this polysaccharide-based hydrogel is not only convenient for clinical operation in oral prosthesis but also has obvious advantages in the sealing of enamel by dental tubules and the enhancement of tooth hardness.
33323027	10	120	theme	CS-MA/SA-SH	1518:1528	arg1	hydrogel					1530:1537	the CS-MA/SA-SH hydrogel	1514:1537	the CS-MA/SA-SH hydrogel with 50% (wt	1514:1550	By examining the properties of hydrogels at different concentrations of calcium and phosphorus salts, we find that the CS-MA/SA-SH hydrogel with 50% (wt.
33323027	5	121	theme	addition	653:660	arg1	reaction					662:669	a rapid and facile Michael addition reaction	626:669	a rapid and facile Michael addition reaction	626:669	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	18	122	theme	novel	2794:2798	arg1	approach					2818:2825	a simple novel "enzyme-promoted" approach	2785:2825	a simple novel "enzyme-promoted" approach	2785:2825	Second, we conferred in vitro mineralization of hydrogels and used a simple novel "enzyme-promoted" approach.
33323027	8	123	theme	SA	1151:1152	arg1	SA					1151:1152	SA	1151:1152	SA	1151:1152	It is worth noting that external Ca2+ can react with the residual carboxyl groups of SA and provide the hydrogel with a self-healing ability.
33323027	8	123	theme	SA	1151:1152	arg1	groups					1141:1146	the residual carboxyl groups	1119:1146	the residual carboxyl groups of SA	1119:1152	It is worth noting that external Ca2+ can react with the residual carboxyl groups of SA and provide the hydrogel with a self-healing ability.
33323027	19	124	theme	stone-structured	3088:3103	arg1	products					3147:3154	37°C, stone-structured, and well-shaped thin-section mineralized products	3082:3154	37°C, stone-structured, and well-shaped thin-section mineralized products	3082:3154	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	19	125	from	products	3147:3154	arg1	hydroxyphospholipids					3020:3039	natural hydroxyphospholipids	3012:3039	natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products	3012:3154	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	19	125	from	products	3147:3154	arg1	environment					3067:3077	a simulated body fluid environment	3044:3077	a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products	3044:3154	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	15	126	theme	dental	2120:2125	arg1	regeneration					2127:2138	dental regeneration	2120:2138	dental regeneration	2120:2138	We believe that this hydrogel can utilize tissues for dental regeneration and mineralization, and the healing ability provides the hydrogel flexibility for further application in hard tissue regeneration.
33323027	6	127	theme	certain	974:980	arg1	ratios					982:987	certain ratios	974:987	certain ratios	974:987	To endue its mineralize ability, β-glycerophosphate calcium phosphate and calcium carbonate as the precursor of hydroxyapatite (HAp) were premixed in the hydrogel at certain ratios.
33323027	21	128	theme	hydrogels	3443:3451	arg1	Comparison					3418:3427	Comparison	3418:3427	Comparison of commercial hydrogels	3418:3451	Comparison of commercial hydrogels further proves that this polysaccharide-based hydrogel is not only convenient for clinical operation in oral prosthesis but also has obvious advantages in the sealing of enamel by dental tubules and the enhancement of tooth hardness.
33323027	19	129	theme	37°C	3082:3085	arg1	products					3147:3154	37°C, stone-structured, and well-shaped thin-section mineralized products	3082:3154	37°C, stone-structured, and well-shaped thin-section mineralized products	3082:3154	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	11	130	theme	crystallized	1651:1662	arg1	Hap					1664:1666	highly crystallized Hap	1644:1666	highly crystallized Hap	1644:1666	%) inorganic matter presented the best self-healing properties, excellent mineralization of highly crystallized Hap, and has ideal cell compatibility.
33323027	21	131	theme	clinical	3535:3542	arg1	operation					3544:3552	clinical operation	3535:3552	clinical operation in oral prosthesis	3535:3571	Comparison of commercial hydrogels further proves that this polysaccharide-based hydrogel is not only convenient for clinical operation in oral prosthesis but also has obvious advantages in the sealing of enamel by dental tubules and the enhancement of tooth hardness.
33323027	1	132	theme	many	139:142	arg1	years					144:148	many years	139:148	many years	139:148	Dental caries have plagued humans for many years.
33323027	3	133	theme	In	324:325	arg1	hydrogels					332:340	In situ hydrogels	324:340	In situ hydrogels with a similar structure to that of the natural extracellular matrix	324:409	In situ hydrogels with a similar structure to that of the natural extracellular matrix have gradually attracted attention in the field of hard tissue repair engineering.
33323027	19	134	theme	thin-section	3122:3133	arg1	products					3147:3154	37°C, stone-structured, and well-shaped thin-section mineralized products	3082:3154	37°C, stone-structured, and well-shaped thin-section mineralized products	3082:3154	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	0	135	theme	Healing	84:90	arg1	Ability					92:98	Ca2+-Induced Healing Ability	71:98	Ca2+-Induced Healing Ability	71:98	Facile Synthesis of In Situ Formable Alginate Composite Hydrogels with Ca2+-Induced Healing Ability.
33323027	16	136	theme	crosslinking	2518:2529	arg1	agents					2531:2536	any crosslinking agents	2514:2536	any crosslinking agents	2514:2536	Impact statement In this article, we report a simple, gentle, and rapid method for the synthesis of new, in situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents.
33323027	12	137	theme	hydrogel	1748:1755	arg1	application					1717:1727	The potential application	1703:1727	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth	1703:1808	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth was explored through preliminary in vitro dental restoration experiments.
33323027	4	138	theme	injectable	498:507	arg1	properties					517:526	The injectable molding properties	494:526	The injectable molding properties of hydrogel	494:538	The injectable molding properties of hydrogel also give it the potential to fill irregularly shaped or fine tissue defects.
33323027	19	139	theme	alkaline	2879:2886	arg1	phosphatase					2888:2898	human body-enriched alkaline phosphatase	2859:2898	human body-enriched alkaline phosphatase	2859:2898	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	19	139	theme	alkaline	2879:2886	arg1	inducer					2906:2912	an inducer	2903:2912	an inducer	2903:2912	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	5	140	theme	CS-maleic	701:709	arg1	[MA					721:723	CS-maleic anhydride [MA]	701:724	CS-maleic anhydride [MA]	701:724	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	5	140	theme	CS-maleic	701:709	arg1	chitosan					691:698	maleic chitosan	684:698	maleic chitosan (CS-maleic anhydride [MA])	684:725	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	12	141	theme	in	1843:1844	arg1	experiments					1871:1881	preliminary in vitro dental restoration experiments	1831:1881	preliminary in vitro dental restoration experiments	1831:1881	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth was explored through preliminary in vitro dental restoration experiments.
33323027	18	142	theme	in	2739:2740	arg1	mineralization					2748:2761	in vitro mineralization	2739:2761	in vitro mineralization of hydrogels	2739:2774	Second, we conferred in vitro mineralization of hydrogels and used a simple novel "enzyme-promoted" approach.
33323027	19	143	theme	human	2859:2863	arg1	phosphatase					2888:2898	human body-enriched alkaline phosphatase	2859:2898	human body-enriched alkaline phosphatase	2859:2898	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	19	143	theme	human	2859:2863	arg1	inducer					2906:2912	an inducer	2903:2912	an inducer	2903:2912	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	2	144	theme	unavoidable	298:308	arg1	cytotoxicity					310:321	unavoidable cytotoxicity	298:321	unavoidable cytotoxicity	298:321	At present, photocrosslinking resin is commonly used in clinics to repair narrow tooth defects, but the ultraviolet light used in this process has unavoidable cytotoxicity.
33323027	12	145	theme	decayed	1796:1802	arg1	teeth					1804:1808	decayed teeth	1796:1808	decayed teeth	1796:1808	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth was explored through preliminary in vitro dental restoration experiments.
33323027	19	146	from	chloride	2979:2986	arg1	rich					2934:2937	rich	2934:2937	rich	2934:2937	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	20	147	with	hydrogel	3190:3197	arg1	ability					3228:3234	in vitro mineralization ability	3204:3234	in vitro mineralization ability	3204:3234	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	20	148	theme	Chinese	3394:3400	arg1	clinics					3409:3415	Chinese dental clinics	3394:3415	Chinese dental clinics	3394:3415	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	14	149	theme	HAp	2012:2014	arg1	morphology					2016:2025	the HAp morphology	2008:2025	the HAp morphology	2008:2025	In addition, the HAp morphology was affected by the local environment.
33323027	19	150	from	calcium	2942:2948	arg1	rich					2934:2937	rich	2934:2937	rich	2934:2937	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	17	151	theme	self-healing	2678:2689	arg1	possibility					2663:2673	the hydrogel the possibility	2646:2673	the hydrogel the possibility of self-healing	2646:2689	The rapid healing ability of the hydrogel can be obtained within 1 min by introducing calcium ions, giving the hydrogel the possibility of self-healing in the cap-enriched state.
33323027	13	152	theme	dental	1975:1980	arg1	sensitizers					1982:1992	commercial dental sensitizers	1964:1992	commercial dental sensitizers	1964:1992	Obviously, the penetration depth through dentin tubules was better than that of commercial dental sensitizers.
33323027	16	153	dep	statement	2278:2286	arg1	article					2296:2302	this article	2291:2302	this article	2291:2302	Impact statement In this article, we report a simple, gentle, and rapid method for the synthesis of new, in situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents.
33323027	17	154	theme	hydrogel	2650:2657	arg1	possibility					2663:2673	the hydrogel the possibility	2646:2673	the hydrogel the possibility of self-healing	2646:2689	The rapid healing ability of the hydrogel can be obtained within 1 min by introducing calcium ions, giving the hydrogel the possibility of self-healing in the cap-enriched state.
33323027	0	155	theme	In	20:21	arg1	Hydrogels					56:64	In Situ Formable Alginate Composite Hydrogels	20:64	In Situ Formable Alginate Composite Hydrogels	20:64	Facile Synthesis of In Situ Formable Alginate Composite Hydrogels with Ca2+-Induced Healing Ability.
33323027	15	156	theme	hydrogel	2197:2204	arg1	flexibility					2206:2216	the hydrogel flexibility	2193:2216	the hydrogel flexibility for further application in hard tissue regeneration	2193:2268	We believe that this hydrogel can utilize tissues for dental regeneration and mineralization, and the healing ability provides the hydrogel flexibility for further application in hard tissue regeneration.
33323027	12	157	theme	exposed	1770:1776	arg1	tubules					1785:1791	exposed dentin tubules	1770:1791	exposed dentin tubules in decayed teeth	1770:1808	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth was explored through preliminary in vitro dental restoration experiments.
33323027	1	158	theme	Dental	101:106	arg1	caries					108:113	Dental caries	101:113	Dental caries	101:113	Dental caries have plagued humans for many years.
33323027	19	159	theme	natural	3012:3018	arg1	hydroxyphospholipids					3020:3039	natural hydroxyphospholipids	3012:3039	natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products	3012:3154	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	19	160	theme	rich	2934:2937	arg1	hydrogels					2924:2932	hydrogels	2924:2932	hydrogels rich in calcium glycerophosphate and calcium chloride	2924:2986	Simulated mineralization using human body-enriched alkaline phosphatase as an inducer, allowing hydrogels rich in calcium glycerophosphate and calcium chloride to be highly similar to natural hydroxyphospholipids in a simulated body fluid environment at 37°C, stone-structured, and well-shaped thin-section mineralized products.
33323027	0	161	theme	Formable	28:35	arg1	Hydrogels					56:64	In Situ Formable Alginate Composite Hydrogels	20:64	In Situ Formable Alginate Composite Hydrogels	20:64	Facile Synthesis of In Situ Formable Alginate Composite Hydrogels with Ca2+-Induced Healing Ability.
33323027	9	162	theme	tissue	1383:1388	arg1	purpose					1354:1360	the purpose	1350:1360	the purpose of regenerating hard tissue	1350:1388	At the same time, we creatively propose a method that uses alkaline phosphatase to promote the mineralization of HAp in hydrogels, to achieve the purpose of regenerating hard tissue in situ.
33323027	20	163	theme	tooth	3351:3355	arg1	agent					3371:3375	the tooth desensitizing agent	3347:3375	the tooth desensitizing agent commonly used in Chinese dental clinics	3347:3415	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	3	164	theme	extracellular	390:402	arg1	matrix					404:409	the natural extracellular matrix	378:409	the natural extracellular matrix	378:409	In situ hydrogels with a similar structure to that of the natural extracellular matrix have gradually attracted attention in the field of hard tissue repair engineering.
33323027	3	165	dep	In	324:325	arg1	situ					327:330	situ	327:330	situ	327:330	In situ hydrogels with a similar structure to that of the natural extracellular matrix have gradually attracted attention in the field of hard tissue repair engineering.
33323027	5	166	theme	alginate	758:765	arg1	-SH					771:773	sodium alginate [SA]-SH	751:773	sodium alginate [SA]-SH	751:773	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	5	166	theme	alginate	758:765	arg1	alginate					741:748	thiolated alginate	731:748	thiolated alginate (sodium alginate [SA]-SH)	731:774	Through a rapid and facile Michael addition reaction, we prepared maleic chitosan (CS-maleic anhydride [MA]) and thiolated alginate (sodium alginate [SA]-SH) to form a CS-MA/SA-SH hydrogel.
33323027	15	167	theme	healing	2168:2174	arg1	ability					2176:2182	the healing ability	2164:2182	the healing ability	2164:2182	We believe that this hydrogel can utilize tissues for dental regeneration and mineralization, and the healing ability provides the hydrogel flexibility for further application in hard tissue regeneration.
33323027	12	168	theme	CS-MA/SA-SH	1736:1746	arg1	hydrogel					1748:1755	the CS-MA/SA-SH hydrogel	1732:1755	the CS-MA/SA-SH hydrogel	1732:1755	The potential application of the CS-MA/SA-SH hydrogel in repairing exposed dentin tubules in decayed teeth was explored through preliminary in vitro dental restoration experiments.
33323027	20	169	theme	mineralization	3213:3226	arg1	ability					3228:3234	in vitro mineralization ability	3204:3234	in vitro mineralization ability	3204:3234	Finally, we use the self-healing hydrogel with in vitro mineralization ability to carry out simple repair and mineralization regeneration of enamel and dentin, and this result is related to the tooth desensitizing agent commonly used in Chinese dental clinics.
33323027	4	170	theme	hydrogel	531:538	arg1	properties					517:526	The injectable molding properties	494:526	The injectable molding properties of hydrogel	494:538	The injectable molding properties of hydrogel also give it the potential to fill irregularly shaped or fine tissue defects.
33323027	0	171	with	Synthesis	7:15	arg1	Ability					92:98	Ca2+-Induced Healing Ability	71:98	Ca2+-Induced Healing Ability	71:98	Facile Synthesis of In Situ Formable Alginate Composite Hydrogels with Ca2+-Induced Healing Ability.
33323027	3	172	theme	repair	474:479	arg1	engineering					481:491	hard tissue repair engineering	462:491	hard tissue repair engineering	462:491	In situ hydrogels with a similar structure to that of the natural extracellular matrix have gradually attracted attention in the field of hard tissue repair engineering.
33323027	21	173	contain	has	3582:3584	arg1	hydrogel					3499:3506	this polysaccharide-based hydrogel	3473:3506	this polysaccharide-based hydrogel	3473:3506	Comparison of commercial hydrogels further proves that this polysaccharide-based hydrogel is not only convenient for clinical operation in oral prosthesis but also has obvious advantages in the sealing of enamel by dental tubules and the enhancement of tooth hardness.
33323027	21	173	contain	has	3582:3584	arg2	advantages					3594:3603	obvious advantages	3586:3603	obvious advantages	3586:3603	Comparison of commercial hydrogels further proves that this polysaccharide-based hydrogel is not only convenient for clinical operation in oral prosthesis but also has obvious advantages in the sealing of enamel by dental tubules and the enhancement of tooth hardness.
33323027	2	174	contain	has	294:296	arg1	light					267:271	the ultraviolet light	251:271	the ultraviolet light used in this process	251:292	At present, photocrosslinking resin is commonly used in clinics to repair narrow tooth defects, but the ultraviolet light used in this process has unavoidable cytotoxicity.
33323027	2	174	contain	has	294:296	arg2	cytotoxicity					310:321	unavoidable cytotoxicity	298:321	unavoidable cytotoxicity	298:321	At present, photocrosslinking resin is commonly used in clinics to repair narrow tooth defects, but the ultraviolet light used in this process has unavoidable cytotoxicity.
33323027	0	175	dep	In	20:21	arg1	Situ					23:26	Situ	23:26	Situ	23:26	Facile Synthesis of In Situ Formable Alginate Composite Hydrogels with Ca2+-Induced Healing Ability.
33323027	6	176	dep	ability	832:838	arg1	mineralize					821:830	mineralize	821:830	mineralize	821:830	To endue its mineralize ability, β-glycerophosphate calcium phosphate and calcium carbonate as the precursor of hydroxyapatite (HAp) were premixed in the hydrogel at certain ratios.
33323027	11	177	theme	self-healing	1591:1602	arg1	properties					1604:1613	the best self-healing properties	1582:1613	the best self-healing properties	1582:1613	%) inorganic matter presented the best self-healing properties, excellent mineralization of highly crystallized Hap, and has ideal cell compatibility.
33323027	11	177	theme	self-healing	1591:1602	arg1	mineralization					1626:1639	excellent mineralization	1616:1639	excellent mineralization of highly crystallized Hap	1616:1666	%) inorganic matter presented the best self-healing properties, excellent mineralization of highly crystallized Hap, and has ideal cell compatibility.
33323027	13	178	theme	penetration	1899:1909	arg1	better					1944:1949	better	1944:1949	better	1944:1949	Obviously, the penetration depth through dentin tubules was better than that of commercial dental sensitizers.
33323027	13	178	theme	penetration	1899:1909	arg1	depth					1911:1915	the penetration depth	1895:1915	the penetration depth through dentin tubules	1895:1938	Obviously, the penetration depth through dentin tubules was better than that of commercial dental sensitizers.
33323027	3	179	theme	hard	462:465	arg1	engineering					481:491	hard tissue repair engineering	462:491	hard tissue repair engineering	462:491	In situ hydrogels with a similar structure to that of the natural extracellular matrix have gradually attracted attention in the field of hard tissue repair engineering.
33323027	11	180	dep	presented	1572:1580	arg1	%					1552:1552	%	1552:1552	%	1552:1552	%) inorganic matter presented the best self-healing properties, excellent mineralization of highly crystallized Hap, and has ideal cell compatibility.
33323027	4	181	theme	tissue	602:607	arg1	defects					609:615	irregularly shaped or fine tissue defects	575:615	irregularly shaped or fine tissue defects	575:615	The injectable molding properties of hydrogel also give it the potential to fill irregularly shaped or fine tissue defects.
33323027	15	182	theme	hard	2245:2248	arg1	regeneration					2257:2268	hard tissue regeneration	2245:2268	hard tissue regeneration	2245:2268	We believe that this hydrogel can utilize tissues for dental regeneration and mineralization, and the healing ability provides the hydrogel flexibility for further application in hard tissue regeneration.
33323027	16	183	theme	rapid	2337:2341	arg1	method					2343:2348	a simple, gentle, and rapid method	2315:2348	a simple, gentle, and rapid method for the synthesis of new	2315:2373	Impact statement In this article, we report a simple, gentle, and rapid method for the synthesis of new, in situ-formable polysaccharide-based hydrogels that are capable of healing through the Michael addition reaction, which does not require any crosslinking agents.
33323027	9	184	theme	HAp	1321:1323	arg1	mineralization					1303:1316	the mineralization	1299:1316	the mineralization of HAp in hydrogels	1299:1336	At the same time, we creatively propose a method that uses alkaline phosphatase to promote the mineralization of HAp in hydrogels, to achieve the purpose of regenerating hard tissue in situ.
34762439	1	0	theme	clay	324:327	arg1	suspensions					256:266	aqueous suspensions	248:266	aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration	248:375	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	7	1	theme	water	1436:1440	arg1	protons					1442:1448	water protons	1436:1448	water protons	1436:1448	In the high-frequency regime, however, the inner-sphere paramagnetic relaxation mechanism dominates, which is caused by the interaction of water protons with dissolved Fe ions.
34762439	4	2	from	effect	805:810	arg1	dynamics					825:832	the water dynamics	815:832	the water dynamics	815:832	Clay alone in moderate concentration was found to enforce almost no effect on the water dynamics, whereas introducing CNCs to the system presented a significantly enhanced relaxivity.
34762439	1	3	theme	time	168:171	arg1	measurements					178:189	1H spin-lattice relaxation time (T1) measurements	141:189	1H spin-lattice relaxation time (T1) measurements	141:189	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	6	4	from	particles	1258:1266	arg1	domain					1289:1294	the low-frequency domain	1271:1294	the low-frequency domain	1271:1294	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	5	5	from	behavior	1050:1057	arg1	suspensions					1080:1090	CNC-clay suspensions	1071:1090	CNC-clay suspensions	1071:1090	The modeling of the relaxation dispersions allowed the determination of dynamical processes and variables explaining the dynamic behavior of water in CNC-clay suspensions.
34762439	0	6	from	Dynamics	6:13	arg1	Suspensions					36:46	Composite Aqueous Suspensions	18:46	Composite Aqueous Suspensions of Cellulose Nanocrystals	18:72	Water Dynamics in Composite Aqueous Suspensions of Cellulose Nanocrystals and a Clay Mineral Studied through Magnetic Resonance Relaxometry.
34762439	6	7	theme	particles	1258:1266	arg1	surfaces					1237:1244	the surfaces	1233:1244	the surfaces of CNC-clay particles in the low-frequency domain	1233:1294	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	4	8	theme	moderate	751:758	arg1	concentration					760:772	moderate concentration	751:772	moderate concentration	751:772	Clay alone in moderate concentration was found to enforce almost no effect on the water dynamics, whereas introducing CNCs to the system presented a significantly enhanced relaxivity.
34762439	1	9	theme	aqueous	248:254	arg1	suspensions					256:266	aqueous suspensions	248:266	aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration	248:375	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	3	10	theme	bulk	670:673	arg1	water					675:679	bulk water	670:679	bulk water	670:679	The experimental relaxometry data illustrate differences between the dynamic behavior of bulk water and that confined in the vicinity of CNC-clay surfaces.
34762439	4	11	theme	introducing	843:853	arg1	CNCs					855:858	introducing CNCs	843:858	introducing CNCs to the system	843:872	Clay alone in moderate concentration was found to enforce almost no effect on the water dynamics, whereas introducing CNCs to the system presented a significantly enhanced relaxivity.
34762439	6	12	theme	relaxation	1185:1194	arg1	mechanism					1196:1204	a leading NMR relaxation mechanism	1171:1204	a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain	1171:1294	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	6	12	theme	relaxation	1185:1194	arg1	reorientations					1112:1125	reorientations	1112:1125	reorientations mediated by translational displacements	1112:1165	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	5	13	theme	CNC-clay	1071:1078	arg1	suspensions					1080:1090	CNC-clay suspensions	1071:1090	CNC-clay suspensions	1071:1090	The modeling of the relaxation dispersions allowed the determination of dynamical processes and variables explaining the dynamic behavior of water in CNC-clay suspensions.
34762439	0	14	theme	Mineral	85:91	arg1	Clay					80:83	a Clay Mineral	78:91	a Clay Mineral	78:91	Water Dynamics in Composite Aqueous Suspensions of Cellulose Nanocrystals and a Clay Mineral Studied through Magnetic Resonance Relaxometry.
34762439	1	15	theme	different	342:350	arg1	degrees					352:358	different degrees	342:358	different degrees of concentration	342:375	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	2	16	theme	resonance	553:561	arg1	techniques					569:578	conventional and fast field cycling nuclear magnetic resonance (NMR) techniques	500:578	conventional and fast field cycling nuclear magnetic resonance (NMR) techniques	500:578	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	4	17	from	Clay	737:740	arg1	concentration					760:772	moderate concentration	751:772	moderate concentration	751:772	Clay alone in moderate concentration was found to enforce almost no effect on the water dynamics, whereas introducing CNCs to the system presented a significantly enhanced relaxivity.
34762439	6	18	theme	NMR	1181:1183	arg1	mechanism					1196:1204	a leading NMR relaxation mechanism	1171:1204	a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain	1171:1294	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	6	18	theme	NMR	1181:1183	arg1	reorientations					1112:1125	reorientations	1112:1125	reorientations mediated by translational displacements	1112:1165	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	0	19	theme	Magnetic	109:116	arg1	Resonance					118:126	Magnetic Resonance	109:126	Magnetic Resonance Relaxometry	109:138	Water Dynamics in Composite Aqueous Suspensions of Cellulose Nanocrystals and a Clay Mineral Studied through Magnetic Resonance Relaxometry.
34762439	5	20	theme	relaxation	941:950	arg1	dispersions					952:962	the relaxation dispersions	937:962	the relaxation dispersions	937:962	The modeling of the relaxation dispersions allowed the determination of dynamical processes and variables explaining the dynamic behavior of water in CNC-clay suspensions.
34762439	1	21	theme	T1	174:175	arg1	measurements					178:189	1H spin-lattice relaxation time (T1) measurements	141:189	1H spin-lattice relaxation time (T1) measurements	141:189	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	7	22	theme	Fe	1465:1466	arg1	ions					1468:1471	dissolved Fe ions	1455:1471	dissolved Fe ions	1455:1471	In the high-frequency regime, however, the inner-sphere paramagnetic relaxation mechanism dominates, which is caused by the interaction of water protons with dissolved Fe ions.
34762439	5	23	theme	dispersions	952:962	arg1	modeling					925:932	The modeling	921:932	The modeling of the relaxation dispersions	921:962	The modeling of the relaxation dispersions allowed the determination of dynamical processes and variables explaining the dynamic behavior of water in CNC-clay suspensions.
34762439	4	24	theme	enhanced	900:907	arg1	relaxivity					909:918	a significantly enhanced relaxivity	884:918	a significantly enhanced relaxivity	884:918	Clay alone in moderate concentration was found to enforce almost no effect on the water dynamics, whereas introducing CNCs to the system presented a significantly enhanced relaxivity.
34762439	6	25	from	domain	1289:1294	arg1	surfaces					1237:1244	the surfaces	1233:1244	the surfaces of CNC-clay particles in the low-frequency domain	1233:1294	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	1	26	theme	concentration	363:375	arg1	degrees					352:358	different degrees	342:358	different degrees of concentration	342:375	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	4	27	theme	water	819:823	arg1	dynamics					825:832	the water dynamics	815:832	the water dynamics	815:832	Clay alone in moderate concentration was found to enforce almost no effect on the water dynamics, whereas introducing CNCs to the system presented a significantly enhanced relaxivity.
34762439	3	28	theme	CNC-clay	718:725	arg1	surfaces					727:734	CNC-clay surfaces	718:734	CNC-clay surfaces	718:734	The experimental relaxometry data illustrate differences between the dynamic behavior of bulk water and that confined in the vicinity of CNC-clay surfaces.
34762439	7	29	theme	protons	1442:1448	arg1	interaction					1421:1431	the interaction	1417:1431	the interaction of water protons with dissolved Fe ions	1417:1471	In the high-frequency regime, however, the inner-sphere paramagnetic relaxation mechanism dominates, which is caused by the interaction of water protons with dissolved Fe ions.
34762439	2	30	theme	1H-T1	378:382	arg1	experiments					384:394	1H-T1 experiments	378:394	1H-T1 experiments	378:394	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	0	31	theme	Water	0:4	arg1	Dynamics					6:13	Water Dynamics	0:13	Water Dynamics in Composite Aqueous Suspensions of Cellulose Nanocrystals	0:72	Water Dynamics in Composite Aqueous Suspensions of Cellulose Nanocrystals and a Clay Mineral Studied through Magnetic Resonance Relaxometry.
34762439	1	32	theme	cellulose	271:279	arg1	CNCs					295:298	CNCs	295:298	CNCs	295:298	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	1	32	theme	cellulose	271:279	arg1	nanocrystals					281:292	cellulose nanocrystals	271:292	cellulose nanocrystals (CNCs)	271:299	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	6	33	theme	CNC-clay	1249:1256	arg1	particles					1258:1266	CNC-clay particles	1249:1266	CNC-clay particles in the low-frequency domain	1249:1294	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	0	34	theme	Composite	18:26	arg1	Suspensions					36:46	Composite Aqueous Suspensions	18:46	Composite Aqueous Suspensions of Cellulose Nanocrystals	18:72	Water Dynamics in Composite Aqueous Suspensions of Cellulose Nanocrystals and a Clay Mineral Studied through Magnetic Resonance Relaxometry.
34762439	1	35	theme	nanocrystals	281:292	arg1	suspensions					256:266	aqueous suspensions	248:266	aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration	248:375	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	2	36	theme	fast	517:520	arg1	techniques					569:578	conventional and fast field cycling nuclear magnetic resonance (NMR) techniques	500:578	conventional and fast field cycling nuclear magnetic resonance (NMR) techniques	500:578	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	6	37	theme	translational	1139:1151	arg1	displacements					1153:1165	translational displacements	1139:1165	translational displacements	1139:1165	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	5	38	theme	dynamical	993:1001	arg1	processes					1003:1011	dynamical processes	993:1011	dynamical processes	993:1011	The modeling of the relaxation dispersions allowed the determination of dynamical processes and variables explaining the dynamic behavior of water in CNC-clay suspensions.
34762439	2	39	theme	wide	420:423	arg1	domain					435:440	a wide frequency domain	418:440	a wide frequency domain	418:440	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	0	40	theme	Resonance	118:126	arg1	Relaxometry					128:138	Magnetic Resonance Relaxometry	109:138	Magnetic Resonance Relaxometry	109:138	Water Dynamics in Composite Aqueous Suspensions of Cellulose Nanocrystals and a Clay Mineral Studied through Magnetic Resonance Relaxometry.
34762439	0	41	from	Clay	80:83	arg1	Suspensions					36:46	Composite Aqueous Suspensions	18:46	Composite Aqueous Suspensions of Cellulose Nanocrystals	18:72	Water Dynamics in Composite Aqueous Suspensions of Cellulose Nanocrystals and a Clay Mineral Studied through Magnetic Resonance Relaxometry.
34762439	2	42	theme	few	458:460	arg1	kilohertz					462:470	a few kilohertz	456:470	a few kilohertz	456:470	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	2	43	theme	conventional	500:511	arg1	techniques					569:578	conventional and fast field cycling nuclear magnetic resonance (NMR) techniques	500:578	conventional and fast field cycling nuclear magnetic resonance (NMR) techniques	500:578	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	5	44	theme	water	1062:1066	arg1	behavior					1050:1057	the dynamic behavior	1038:1057	the dynamic behavior of water in CNC-clay suspensions	1038:1090	The modeling of the relaxation dispersions allowed the determination of dynamical processes and variables explaining the dynamic behavior of water in CNC-clay suspensions.
34762439	1	45	theme	mineral	329:335	arg1	clay					324:327	a layered smectite clay	305:327	a layered smectite clay mineral with different degrees of concentration	305:375	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	6	46	from	surfaces	1237:1244	arg1	domain					1289:1294	the low-frequency domain	1271:1294	the low-frequency domain	1271:1294	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	7	47	theme	dissolved	1455:1463	arg1	ions					1468:1471	dissolved Fe ions	1455:1471	dissolved Fe ions	1455:1471	In the high-frequency regime, however, the inner-sphere paramagnetic relaxation mechanism dominates, which is caused by the interaction of water protons with dissolved Fe ions.
34762439	0	48	theme	Aqueous	28:34	arg1	Suspensions					36:46	Composite Aqueous Suspensions	18:46	Composite Aqueous Suspensions of Cellulose Nanocrystals	18:72	Water Dynamics in Composite Aqueous Suspensions of Cellulose Nanocrystals and a Clay Mineral Studied through Magnetic Resonance Relaxometry.
34762439	2	49	dep	the	489:491	arg1	aid					493:495	aid	493:495	aid	493:495	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	3	50	theme	relaxometry	598:608	arg1	data					610:613	The experimental relaxometry data	581:613	The experimental relaxometry data	581:613	The experimental relaxometry data illustrate differences between the dynamic behavior of bulk water and that confined in the vicinity of CNC-clay surfaces.
34762439	2	51	theme	frequency	425:433	arg1	domain					435:440	a wide frequency domain	418:440	a wide frequency domain	418:440	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	0	52	theme	Cellulose	51:59	arg1	Nanocrystals					61:72	Cellulose Nanocrystals	51:72	Cellulose Nanocrystals	51:72	Water Dynamics in Composite Aqueous Suspensions of Cellulose Nanocrystals and a Clay Mineral Studied through Magnetic Resonance Relaxometry.
34762439	2	53	theme	magnetic	544:551	arg1	NMR					564:566	NMR	564:566	NMR	564:566	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	2	53	theme	magnetic	544:551	arg1	resonance					553:561	field cycling nuclear magnetic resonance	522:561	conventional and fast field cycling nuclear magnetic resonance (NMR) techniques	500:578	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	3	54	theme	surfaces	727:734	arg1	vicinity					706:713	the vicinity	702:713	the vicinity of CNC-clay surfaces	702:734	The experimental relaxometry data illustrate differences between the dynamic behavior of bulk water and that confined in the vicinity of CNC-clay surfaces.
34762439	6	55	dep	turned	1096:1101	arg1	out					1103:1105	out	1103:1105	out	1103:1105	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	6	56	theme	low-frequency	1275:1287	arg1	domain					1289:1294	the low-frequency domain	1271:1294	the low-frequency domain	1271:1294	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	2	57	theme	nuclear	536:542	arg1	NMR					564:566	NMR	564:566	NMR	564:566	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	2	57	theme	nuclear	536:542	arg1	resonance					553:561	field cycling nuclear magnetic resonance	522:561	conventional and fast field cycling nuclear magnetic resonance (NMR) techniques	500:578	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	3	58	theme	dynamic	650:656	arg1	behavior					658:665	the dynamic behavior	646:665	the dynamic behavior of bulk water	646:679	The experimental relaxometry data illustrate differences between the dynamic behavior of bulk water and that confined in the vicinity of CNC-clay surfaces.
34762439	7	59	theme	inner-sphere	1340:1351	arg1	mechanism					1377:1385	the inner-sphere paramagnetic relaxation mechanism	1336:1385	the inner-sphere paramagnetic relaxation mechanism	1336:1385	In the high-frequency regime, however, the inner-sphere paramagnetic relaxation mechanism dominates, which is caused by the interaction of water protons with dissolved Fe ions.
34762439	3	60	theme	water	675:679	arg1	behavior					658:665	the dynamic behavior	646:665	the dynamic behavior of bulk water	646:679	The experimental relaxometry data illustrate differences between the dynamic behavior of bulk water and that confined in the vicinity of CNC-clay surfaces.
34762439	1	61	theme	layered	307:313	arg1	clay					324:327	a layered smectite clay	305:327	a layered smectite clay mineral with different degrees of concentration	305:375	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	2	62	theme	cycling	528:534	arg1	NMR					564:566	NMR	564:566	NMR	564:566	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	2	62	theme	cycling	528:534	arg1	resonance					553:561	field cycling nuclear magnetic resonance	522:561	conventional and fast field cycling nuclear magnetic resonance (NMR) techniques	500:578	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	5	63	theme	processes	1003:1011	arg1	determination					976:988	the determination	972:988	the determination of dynamical processes	972:1011	The modeling of the relaxation dispersions allowed the determination of dynamical processes and variables explaining the dynamic behavior of water in CNC-clay suspensions.
34762439	5	63	theme	processes	1003:1011	arg1	variables					1017:1025	variables	1017:1025	variables explaining the dynamic behavior of water in CNC-clay suspensions	1017:1090	The modeling of the relaxation dispersions allowed the determination of dynamical processes and variables explaining the dynamic behavior of water in CNC-clay suspensions.
34762439	7	64	dep	regime	1319:1324	arg1	high-frequency					1304:1317	high-frequency	1304:1317	high-frequency	1304:1317	In the high-frequency regime, however, the inner-sphere paramagnetic relaxation mechanism dominates, which is caused by the interaction of water protons with dissolved Fe ions.
34762439	1	65	theme	dynamic	219:225	arg1	behavior					227:234	the dynamic behavior	215:234	the dynamic behavior of water	215:243	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	2	66	theme	field	522:526	arg1	NMR					564:566	NMR	564:566	NMR	564:566	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	2	66	theme	field	522:526	arg1	resonance					553:561	field cycling nuclear magnetic resonance	522:561	conventional and fast field cycling nuclear magnetic resonance (NMR) techniques	500:578	1H-T1 experiments were carried out over a wide frequency domain, ranging from a few kilohertz to 500 MHz, with the aid of conventional and fast field cycling nuclear magnetic resonance (NMR) techniques.
34762439	5	67	theme	dynamic	1042:1048	arg1	behavior					1050:1057	the dynamic behavior	1038:1057	the dynamic behavior of water in CNC-clay suspensions	1038:1090	The modeling of the relaxation dispersions allowed the determination of dynamical processes and variables explaining the dynamic behavior of water in CNC-clay suspensions.
34762439	3	68	theme	experimental	585:596	arg1	data					610:613	The experimental relaxometry data	581:613	The experimental relaxometry data	581:613	The experimental relaxometry data illustrate differences between the dynamic behavior of bulk water and that confined in the vicinity of CNC-clay surfaces.
34762439	1	69	theme	1H	141:142	arg1	measurements					178:189	1H spin-lattice relaxation time (T1) measurements	141:189	1H spin-lattice relaxation time (T1) measurements	141:189	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	7	70	with	interaction	1421:1431	arg1	ions					1468:1471	dissolved Fe ions	1455:1471	dissolved Fe ions	1455:1471	In the high-frequency regime, however, the inner-sphere paramagnetic relaxation mechanism dominates, which is caused by the interaction of water protons with dissolved Fe ions.
34762439	7	71	theme	paramagnetic	1353:1364	arg1	mechanism					1377:1385	the inner-sphere paramagnetic relaxation mechanism	1336:1385	the inner-sphere paramagnetic relaxation mechanism	1336:1385	In the high-frequency regime, however, the inner-sphere paramagnetic relaxation mechanism dominates, which is caused by the interaction of water protons with dissolved Fe ions.
34762439	1	72	theme	spin-lattice	144:155	arg1	measurements					178:189	1H spin-lattice relaxation time (T1) measurements	141:189	1H spin-lattice relaxation time (T1) measurements	141:189	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	6	73	theme	leading	1173:1179	arg1	mechanism					1196:1204	a leading NMR relaxation mechanism	1171:1204	a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain	1171:1294	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	6	73	theme	leading	1173:1179	arg1	reorientations					1112:1125	reorientations	1112:1125	reorientations mediated by translational displacements	1112:1165	It turned out that reorientations mediated by translational displacements are a leading NMR relaxation mechanism for water interacting with the surfaces of CNC-clay particles in the low-frequency domain.
34762439	0	74	theme	Nanocrystals	61:72	arg1	Suspensions					36:46	Composite Aqueous Suspensions	18:46	Composite Aqueous Suspensions of Cellulose Nanocrystals	18:72	Water Dynamics in Composite Aqueous Suspensions of Cellulose Nanocrystals and a Clay Mineral Studied through Magnetic Resonance Relaxometry.
34762439	1	75	theme	smectite	315:322	arg1	clay					324:327	a layered smectite clay	305:327	a layered smectite clay mineral with different degrees of concentration	305:375	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	7	76	theme	relaxation	1366:1375	arg1	mechanism					1377:1385	the inner-sphere paramagnetic relaxation mechanism	1336:1385	the inner-sphere paramagnetic relaxation mechanism	1336:1385	In the high-frequency regime, however, the inner-sphere paramagnetic relaxation mechanism dominates, which is caused by the interaction of water protons with dissolved Fe ions.
34762439	1	77	theme	relaxation	157:166	arg1	measurements					178:189	1H spin-lattice relaxation time (T1) measurements	141:189	1H spin-lattice relaxation time (T1) measurements	141:189	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	1	78	with	mineral	329:335	arg1	degrees					352:358	different degrees	342:358	different degrees of concentration	342:375	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34762439	1	79	theme	water	239:243	arg1	behavior					227:234	the dynamic behavior	215:234	the dynamic behavior of water	215:243	1H spin-lattice relaxation time (T1) measurements were performed to probe the dynamic behavior of water in aqueous suspensions of cellulose nanocrystals (CNCs) and a layered smectite clay mineral with different degrees of concentration.
34474849	7	0	theme	Antimicrobial	1295:1307	arg1	properties					1309:1318	Antimicrobial properties	1295:1318	Antimicrobial properties of nanocomposite membranes	1295:1345	Antimicrobial properties of nanocomposite membranes were investigated with tube dilution and disk diffusion methods.
34474849	3	1	theme	nanofiber	712:720	arg1	layer					728:732	chitosan/PEO nanofiber upper layer	699:732	chitosan/PEO nanofiber upper layer	699:732	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	13	2	theme	bone	2091:2094	arg1	regeneration					2096:2107	guided bone regeneration	2084:2107	guided bone regeneration in periodontal applications	2084:2135	Thus, results supported that designed bilayer nanocomposite membranes can be used as a potential biomaterial for guided bone regeneration in periodontal applications.
34474849	12	3	theme	cells	1878:1882	arg1	bioactivity					1856:1866	the bioactivity	1852:1866	the bioactivity of Saos-2 cells	1852:1882	Besides, Si-nHap loading induced the bioactivity of Saos-2 cells by enhancing cell attachment, spreading and biomineralization on the material surface.
34474849	1	4	from	defect	302:307	arg1	formation					246:254	the formation	242:254	the formation of surrounding soft tissue at the periodontal defect	242:307	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	1	5	theme	surrounding	259:269	arg1	tissue					276:281	surrounding soft tissue	259:281	surrounding soft tissue	259:281	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	6	6	theme	compression	1222:1232	arg1	test					1234:1237	compression test	1222:1237	compression test	1222:1237	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	7	7	theme	diffusion	1393:1401	arg1	methods					1403:1409	disk diffusion methods	1388:1409	disk diffusion methods	1388:1409	Antimicrobial properties of nanocomposite membranes were investigated with tube dilution and disk diffusion methods.
34474849	4	8	theme	osteogenic	890:899	arg1	bioactivity					906:916	osteogenic cell bioactivity	890:916	osteogenic cell bioactivity	890:916	Bilayer membrane was designed to prevent epithelial and fibroblastic cell migration and growth impeding bone formation with its upper layer and to support osteogenic cell bioactivity at the defect site with its sublayer.
34474849	6	9	theme	micro-Ct	1212:1219	arg1	study					1288:1292	SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study	1202:1292	SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study	1202:1292	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	6	10	theme	AFM	1207:1209	arg1	study					1288:1292	SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study	1202:1292	SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study	1202:1292	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	3	11	theme	bilayer	565:571	arg1	membrane					587:594	a novel bilayer nanocomposite membrane	557:594	a novel bilayer nanocomposite membrane	557:594	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	6	12	theme	degradation	1276:1286	arg1	study					1288:1292	SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study	1202:1292	SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study	1202:1292	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	3	13	theme	microporous	601:611	arg1	sublayer					613:620	microporous sublayer	601:620	microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap)	601:693	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	1	14	theme	Guided	134:139	arg1	GBR					160:162	GBR	160:162	GBR	160:162	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	1	14	theme	Guided	134:139	arg1	Regeneration					146:157	Guided Bone Regeneration	134:157	Guided Bone Regeneration (GBR)	134:163	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	1	14	theme	Guided	134:139	arg1	process					182:188	a widely used process	168:188	a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration	168:347	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	12	15	theme	Si-nHap	1828:1834	arg1	loading					1836:1842	Si-nHap loading	1828:1842	Si-nHap loading	1828:1842	Besides, Si-nHap loading induced the bioactivity of Saos-2 cells by enhancing cell attachment, spreading and biomineralization on the material surface.
34474849	3	16	theme	Si	647:648	arg1	particles					675:683	chitosan and Si doped nanohydroxyapatite particles	634:683	chitosan and Si doped nanohydroxyapatite particles (Si-nHap)	634:693	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	3	16	theme	Si	647:648	arg1	Si-nHap					686:692	Si-nHap	686:692	Si-nHap	686:692	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	6	17	theme	uptake	1246:1251	arg1	capacity					1253:1260	water uptake capacity	1240:1260	water uptake capacity	1240:1260	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	0	18	theme	chitosan	63:70	arg1	membranes					94:102	bilayer chitosan nanocomposite barrier membranes	55:102	bilayer chitosan nanocomposite barrier membranes	55:102	Development of Si doped nano hydroxyapatite reinforced bilayer chitosan nanocomposite barrier membranes for guided bone regeneration.
34474849	3	19	theme	chitosan	634:641	arg1	particles					675:683	chitosan and Si doped nanohydroxyapatite particles	634:683	chitosan and Si doped nanohydroxyapatite particles (Si-nHap)	634:693	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	3	19	theme	chitosan	634:641	arg1	Si-nHap					686:692	Si-nHap	686:692	Si-nHap	686:692	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	6	20	from	effect	1077:1082	arg1	properties					1149:1158	the morphological, mechanical and physical properties	1106:1158	the morphological, mechanical and physical properties of the composites	1106:1176	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	8	21	theme	In	1412:1413	arg1	cytotoxicity					1421:1432	In vitro cytotoxicity	1412:1432	In vitro cytotoxicity of bilayer membranes	1412:1453	In vitro cytotoxicity of bilayer membranes was evaluated.
34474849	13	22	theme	nanocomposite	2017:2029	arg1	membranes					2031:2039	designed bilayer nanocomposite membranes	2000:2039	designed bilayer nanocomposite membranes	2000:2039	Thus, results supported that designed bilayer nanocomposite membranes can be used as a potential biomaterial for guided bone regeneration in periodontal applications.
34474849	4	23	with	formation	844:852	arg1	layer					869:873	its upper layer	859:873	its upper layer	859:873	Bilayer membrane was designed to prevent epithelial and fibroblastic cell migration and growth impeding bone formation with its upper layer and to support osteogenic cell bioactivity at the defect site with its sublayer.
34474849	0	24	theme	barrier	86:92	arg1	membranes					94:102	bilayer chitosan nanocomposite barrier membranes	55:102	bilayer chitosan nanocomposite barrier membranes	55:102	Development of Si doped nano hydroxyapatite reinforced bilayer chitosan nanocomposite barrier membranes for guided bone regeneration.
34474849	1	25	theme	tissue	329:334	arg1	regeneration					336:347	hard tissue regeneration	324:347	hard tissue regeneration	324:347	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	13	26	from	regeneration	2096:2107	arg1	applications					2124:2135	periodontal applications	2112:2135	periodontal applications	2112:2135	Thus, results supported that designed bilayer nanocomposite membranes can be used as a potential biomaterial for guided bone regeneration in periodontal applications.
34474849	4	27	theme	cell	804:807	arg1	migration					809:817	epithelial and fibroblastic cell migration	776:817	epithelial and fibroblastic cell migration	776:817	Bilayer membrane was designed to prevent epithelial and fibroblastic cell migration and growth impeding bone formation with its upper layer and to support osteogenic cell bioactivity at the defect site with its sublayer.
34474849	8	28	theme	bilayer	1437:1443	arg1	membranes					1445:1453	bilayer membranes	1437:1453	bilayer membranes	1437:1453	In vitro cytotoxicity of bilayer membranes was evaluated.
34474849	0	29	theme	bone	115:118	arg1	regeneration					120:131	guided bone regeneration	108:131	guided bone regeneration	108:131	Development of Si doped nano hydroxyapatite reinforced bilayer chitosan nanocomposite barrier membranes for guided bone regeneration.
34474849	13	30	theme	designed	2000:2007	arg1	membranes					2031:2039	designed bilayer nanocomposite membranes	2000:2039	designed bilayer nanocomposite membranes	2000:2039	Thus, results supported that designed bilayer nanocomposite membranes can be used as a potential biomaterial for guided bone regeneration in periodontal applications.
34474849	10	31	dep	In	1543:1544	arg1	vitro					1546:1550	vitro	1546:1550	vitro	1546:1550	In vitro bioactivity of Saos-2 and NIH/3T3 cells were evaluated with ALP activity and hydroxyproline content respectively.
34474849	1	32	theme	soft	271:274	arg1	tissue					276:281	surrounding soft tissue	259:281	surrounding soft tissue	259:281	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	2	33	theme	barrier	439:445	arg1	membranes					447:455	resorbable natural polymer-based barrier membranes	406:455	resorbable natural polymer-based barrier membranes	406:455	Recently GBR designs have focused on the development of resorbable natural polymer-based barrier membranes due to their biodegradability and excellent biocompatibility.
34474849	10	34	theme	cells	1586:1590	arg1	bioactivity					1552:1562	In vitro bioactivity	1543:1562	In vitro bioactivity of Saos-2 and NIH/3T3 cells	1543:1590	In vitro bioactivity of Saos-2 and NIH/3T3 cells were evaluated with ALP activity and hydroxyproline content respectively.
34474849	13	35	used	used	2048:2051	arg2	results					1977:1983	results	1977:1983	results supported that designed bilayer nanocomposite membranes	1977:2039	Thus, results supported that designed bilayer nanocomposite membranes can be used as a potential biomaterial for guided bone regeneration in periodontal applications.
34474849	13	35	used	used	2048:2051	arg2	biomaterial					2068:2078	biomaterial	2068:2078	biomaterial	2068:2078	Thus, results supported that designed bilayer nanocomposite membranes can be used as a potential biomaterial for guided bone regeneration in periodontal applications.
34474849	2	36	theme	natural	417:423	arg1	membranes					447:455	resorbable natural polymer-based barrier membranes	406:455	resorbable natural polymer-based barrier membranes	406:455	Recently GBR designs have focused on the development of resorbable natural polymer-based barrier membranes due to their biodegradability and excellent biocompatibility.
34474849	0	37	theme	Si	15:16	arg1	hydroxyapatite					29:42	Si doped nano hydroxyapatite	15:42	Si doped nano hydroxyapatite	15:42	Development of Si doped nano hydroxyapatite reinforced bilayer chitosan nanocomposite barrier membranes for guided bone regeneration.
34474849	4	38	with	site	932:935	arg1	sublayer					946:953	its sublayer	942:953	its sublayer	942:953	Bilayer membrane was designed to prevent epithelial and fibroblastic cell migration and growth impeding bone formation with its upper layer and to support osteogenic cell bioactivity at the defect site with its sublayer.
34474849	7	39	theme	disk	1388:1391	arg1	methods					1403:1409	disk diffusion methods	1388:1409	disk diffusion methods	1388:1409	Antimicrobial properties of nanocomposite membranes were investigated with tube dilution and disk diffusion methods.
34474849	0	40	theme	nano	24:27	arg1	hydroxyapatite					29:42	Si doped nano hydroxyapatite	15:42	Si doped nano hydroxyapatite	15:42	Development of Si doped nano hydroxyapatite reinforced bilayer chitosan nanocomposite barrier membranes for guided bone regeneration.
34474849	1	41	theme	periodontal	290:300	arg1	defect					302:307	the periodontal defect	286:307	the periodontal defect	286:307	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	6	42	theme	content	1095:1101	arg1	effect					1077:1082	The effect	1073:1082	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites	1073:1176	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	10	43	theme	ALP	1612:1614	arg1	activity					1616:1623	ALP activity	1612:1623	ALP activity	1612:1623	In vitro bioactivity of Saos-2 and NIH/3T3 cells were evaluated with ALP activity and hydroxyproline content respectively.
34474849	3	44	theme	nanohydroxyapatite	656:673	arg1	particles					675:683	chitosan and Si doped nanohydroxyapatite particles	634:683	chitosan and Si doped nanohydroxyapatite particles (Si-nHap)	634:693	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	3	44	theme	nanohydroxyapatite	656:673	arg1	Si-nHap					686:692	Si-nHap	686:692	Si-nHap	686:692	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	12	45	theme	material	1953:1960	arg1	surface					1962:1968	the material surface	1949:1968	the material surface	1949:1968	Besides, Si-nHap loading induced the bioactivity of Saos-2 cells by enhancing cell attachment, spreading and biomineralization on the material surface.
34474849	11	46	theme	polymer	1803:1809	arg1	matrix					1811:1816	the polymer matrix	1799:1816	the polymer matrix	1799:1816	Results showed that Si-nHap incorporation enhanced the mechanical and physical properties as well as controlling biodegradability of the polymer matrix.
34474849	3	47	theme	chitosan/PEO	699:710	arg1	layer					728:732	chitosan/PEO nanofiber upper layer	699:732	chitosan/PEO nanofiber upper layer	699:732	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	1	48	dep	treatment	198:206	arg1	provide					316:322	provide	316:322	to provide hard tissue regeneration	313:347	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	1	48	dep	treatment	198:206	arg1	prevent					234:240	prevent	234:240	to prevent the formation of surrounding soft tissue at the periodontal defect	231:307	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	11	49	theme	Si-nHap	1686:1692	arg1	incorporation					1694:1706	Si-nHap incorporation	1686:1706	Si-nHap incorporation	1686:1706	Results showed that Si-nHap incorporation enhanced the mechanical and physical properties as well as controlling biodegradability of the polymer matrix.
34474849	1	50	theme	periodontal	211:221	arg1	defects					223:229	periodontal defects	211:229	periodontal defects	211:229	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	5	51	dep	Microporous	956:966	arg1	layers					982:987	layers	982:987	layers	982:987	Microporous and nanofiber layers were fabricated by using freeze-drying and electrospinning techniques respectively.
34474849	11	52	theme	physical	1736:1743	arg1	properties					1745:1754	the mechanical and physical properties	1717:1754	the mechanical and physical properties as well as controlling biodegradability of the polymer matrix	1717:1816	Results showed that Si-nHap incorporation enhanced the mechanical and physical properties as well as controlling biodegradability of the polymer matrix.
34474849	9	53	theme	NIH/3T3	1481:1487	arg1	studies					1503:1509	NIH/3T3 proliferation studies	1481:1509	NIH/3T3 proliferation studies	1481:1509	Saos-2 and NIH/3T3 proliferation studies were carried out on each layer.
34474849	7	54	theme	nanocomposite	1323:1335	arg1	membranes					1337:1345	nanocomposite membranes	1323:1345	nanocomposite membranes	1323:1345	Antimicrobial properties of nanocomposite membranes were investigated with tube dilution and disk diffusion methods.
34474849	11	55	theme	mechanical	1721:1730	arg1	properties					1745:1754	the mechanical and physical properties	1717:1754	the mechanical and physical properties as well as controlling biodegradability of the polymer matrix	1717:1816	Results showed that Si-nHap incorporation enhanced the mechanical and physical properties as well as controlling biodegradability of the polymer matrix.
34474849	4	56	theme	cell	901:904	arg1	bioactivity					906:916	osteogenic cell bioactivity	890:916	osteogenic cell bioactivity	890:916	Bilayer membrane was designed to prevent epithelial and fibroblastic cell migration and growth impeding bone formation with its upper layer and to support osteogenic cell bioactivity at the defect site with its sublayer.
34474849	11	57	theme	matrix	1811:1816	arg1	biodegradability					1779:1794	biodegradability	1779:1794	biodegradability of the polymer matrix	1779:1816	Results showed that Si-nHap incorporation enhanced the mechanical and physical properties as well as controlling biodegradability of the polymer matrix.
34474849	3	58	theme	upper	722:726	arg1	layer					728:732	chitosan/PEO nanofiber upper layer	699:732	chitosan/PEO nanofiber upper layer	699:732	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	12	59	theme	cell	1897:1900	arg1	attachment					1902:1911	cell attachment	1897:1911	cell attachment	1897:1911	Besides, Si-nHap loading induced the bioactivity of Saos-2 cells by enhancing cell attachment, spreading and biomineralization on the material surface.
34474849	6	60	theme	test	1234:1237	arg1	study					1288:1292	SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study	1202:1292	SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study	1202:1292	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	13	61	theme	periodontal	2112:2122	arg1	applications					2124:2135	periodontal applications	2112:2135	periodontal applications	2112:2135	Thus, results supported that designed bilayer nanocomposite membranes can be used as a potential biomaterial for guided bone regeneration in periodontal applications.
34474849	3	62	theme	nanocomposite	573:585	arg1	membrane					587:594	a novel bilayer nanocomposite membrane	557:594	a novel bilayer nanocomposite membrane	557:594	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	1	63	theme	used	177:180	arg1	process					182:188	a widely used process	168:188	a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration	168:347	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	1	63	theme	used	177:180	arg1	Regeneration					146:157	Guided Bone Regeneration	134:157	Guided Bone Regeneration (GBR)	134:163	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	12	64	theme	Saos-2	1871:1876	arg1	cells					1878:1882	Saos-2 cells	1871:1882	Saos-2 cells	1871:1882	Besides, Si-nHap loading induced the bioactivity of Saos-2 cells by enhancing cell attachment, spreading and biomineralization on the material surface.
34474849	13	65	theme	guided	2084:2089	arg1	regeneration					2096:2107	guided bone regeneration	2084:2107	guided bone regeneration in periodontal applications	2084:2135	Thus, results supported that designed bilayer nanocomposite membranes can be used as a potential biomaterial for guided bone regeneration in periodontal applications.
34474849	3	66	theme	novel	559:563	arg1	membrane					587:594	a novel bilayer nanocomposite membrane	557:594	a novel bilayer nanocomposite membrane	557:594	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	4	67	theme	defect	925:930	arg1	site					932:935	the defect site	921:935	the defect site with its sublayer	921:953	Bilayer membrane was designed to prevent epithelial and fibroblastic cell migration and growth impeding bone formation with its upper layer and to support osteogenic cell bioactivity at the defect site with its sublayer.
34474849	6	68	theme	enzymatic	1266:1274	arg1	degradation					1276:1286	enzymatic degradation	1266:1286	enzymatic degradation	1266:1286	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	4	69	theme	Bilayer	735:741	arg1	membrane					743:750	Bilayer membrane	735:750	Bilayer membrane	735:750	Bilayer membrane was designed to prevent epithelial and fibroblastic cell migration and growth impeding bone formation with its upper layer and to support osteogenic cell bioactivity at the defect site with its sublayer.
34474849	1	70	theme	Bone	141:144	arg1	GBR					160:162	GBR	160:162	GBR	160:162	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	1	70	theme	Bone	141:144	arg1	Regeneration					146:157	Guided Bone Regeneration	134:157	Guided Bone Regeneration (GBR)	134:163	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	1	70	theme	Bone	141:144	arg1	process					182:188	a widely used process	168:188	a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration	168:347	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	6	71	theme	Si-nHap	1087:1093	arg1	content					1095:1101	Si-nHap content	1087:1101	Si-nHap content	1087:1101	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	6	72	theme	capacity	1253:1260	arg1	study					1288:1292	SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study	1202:1292	SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study	1202:1292	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	0	73	theme	nanocomposite	72:84	arg1	membranes					94:102	bilayer chitosan nanocomposite barrier membranes	55:102	bilayer chitosan nanocomposite barrier membranes	55:102	Development of Si doped nano hydroxyapatite reinforced bilayer chitosan nanocomposite barrier membranes for guided bone regeneration.
34474849	6	74	theme	water	1240:1244	arg1	capacity					1253:1260	water uptake capacity	1240:1260	water uptake capacity	1240:1260	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	13	75	theme	bilayer	2009:2015	arg1	membranes					2031:2039	designed bilayer nanocomposite membranes	2000:2039	designed bilayer nanocomposite membranes	2000:2039	Thus, results supported that designed bilayer nanocomposite membranes can be used as a potential biomaterial for guided bone regeneration in periodontal applications.
34474849	1	76	theme	hard	324:327	arg1	regeneration					336:347	hard tissue regeneration	324:347	hard tissue regeneration	324:347	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	2	77	theme	excellent	491:499	arg1	biocompatibility					501:516	excellent biocompatibility	491:516	excellent biocompatibility	491:516	Recently GBR designs have focused on the development of resorbable natural polymer-based barrier membranes due to their biodegradability and excellent biocompatibility.
34474849	0	78	theme	guided	108:113	arg1	regeneration					120:131	guided bone regeneration	108:131	guided bone regeneration	108:131	Development of Si doped nano hydroxyapatite reinforced bilayer chitosan nanocomposite barrier membranes for guided bone regeneration.
34474849	4	79	theme	fibroblastic	791:802	arg1	migration					809:817	epithelial and fibroblastic cell migration	776:817	epithelial and fibroblastic cell migration	776:817	Bilayer membrane was designed to prevent epithelial and fibroblastic cell migration and growth impeding bone formation with its upper layer and to support osteogenic cell bioactivity at the defect site with its sublayer.
34474849	5	80	theme	freeze-drying	1014:1026	arg1	techniques					1048:1057	freeze-drying and electrospinning techniques	1014:1057	freeze-drying and electrospinning techniques	1014:1057	Microporous and nanofiber layers were fabricated by using freeze-drying and electrospinning techniques respectively.
34474849	6	81	theme	physical	1140:1147	arg1	properties					1149:1158	the morphological, mechanical and physical properties	1106:1158	the morphological, mechanical and physical properties of the composites	1106:1176	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	6	82	theme	mechanical	1125:1134	arg1	properties					1149:1158	the morphological, mechanical and physical properties	1106:1158	the morphological, mechanical and physical properties of the composites	1106:1176	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	2	83	theme	membranes	447:455	arg1	development					391:401	the development	387:401	the development of resorbable natural polymer-based barrier membranes due to their biodegradability and excellent biocompatibility	387:516	Recently GBR designs have focused on the development of resorbable natural polymer-based barrier membranes due to their biodegradability and excellent biocompatibility.
34474849	10	84	theme	In	1543:1544	arg1	bioactivity					1552:1562	In vitro bioactivity	1543:1562	In vitro bioactivity of Saos-2 and NIH/3T3 cells	1543:1590	In vitro bioactivity of Saos-2 and NIH/3T3 cells were evaluated with ALP activity and hydroxyproline content respectively.
34474849	8	85	theme	membranes	1445:1453	arg1	cytotoxicity					1421:1432	In vitro cytotoxicity	1412:1432	In vitro cytotoxicity of bilayer membranes	1412:1453	In vitro cytotoxicity of bilayer membranes was evaluated.
34474849	0	86	theme	doped	18:22	arg1	hydroxyapatite					29:42	Si doped nano hydroxyapatite	15:42	Si doped nano hydroxyapatite	15:42	Development of Si doped nano hydroxyapatite reinforced bilayer chitosan nanocomposite barrier membranes for guided bone regeneration.
34474849	1	87	theme	tissue	276:281	arg1	formation					246:254	the formation	242:254	the formation of surrounding soft tissue at the periodontal defect	242:307	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	6	88	theme	morphological	1110:1122	arg1	properties					1149:1158	the morphological, mechanical and physical properties	1106:1158	the morphological, mechanical and physical properties of the composites	1106:1176	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	2	89	theme	polymer-based	425:437	arg1	membranes					447:455	resorbable natural polymer-based barrier membranes	406:455	resorbable natural polymer-based barrier membranes	406:455	Recently GBR designs have focused on the development of resorbable natural polymer-based barrier membranes due to their biodegradability and excellent biocompatibility.
34474849	10	90	theme	NIH/3T3	1578:1584	arg1	cells					1586:1590	Saos-2 and NIH/3T3 cells	1567:1590	cells	1586:1590	In vitro bioactivity of Saos-2 and NIH/3T3 cells were evaluated with ALP activity and hydroxyproline content respectively.
34474849	4	91	theme	epithelial	776:785	arg1	migration					809:817	epithelial and fibroblastic cell migration	776:817	epithelial and fibroblastic cell migration	776:817	Bilayer membrane was designed to prevent epithelial and fibroblastic cell migration and growth impeding bone formation with its upper layer and to support osteogenic cell bioactivity at the defect site with its sublayer.
34474849	2	92	theme	resorbable	406:415	arg1	membranes					447:455	resorbable natural polymer-based barrier membranes	406:455	resorbable natural polymer-based barrier membranes	406:455	Recently GBR designs have focused on the development of resorbable natural polymer-based barrier membranes due to their biodegradability and excellent biocompatibility.
34474849	0	93	theme	hydroxyapatite	29:42	arg1	Development					0:10	Development	0:10	Development of Si doped nano hydroxyapatite	0:42	Development of Si doped nano hydroxyapatite reinforced bilayer chitosan nanocomposite barrier membranes for guided bone regeneration.
34474849	8	94	dep	In	1412:1413	arg1	vitro					1415:1419	vitro	1415:1419	vitro	1415:1419	In vitro cytotoxicity of bilayer membranes was evaluated.
34474849	7	95	theme	tube	1370:1373	arg1	dilution					1375:1382	tube dilution	1370:1382	tube dilution	1370:1382	Antimicrobial properties of nanocomposite membranes were investigated with tube dilution and disk diffusion methods.
34474849	10	96	theme	Saos-2	1567:1572	arg1	cells					1586:1590	Saos-2 and NIH/3T3 cells	1567:1590	cells	1586:1590	In vitro bioactivity of Saos-2 and NIH/3T3 cells were evaluated with ALP activity and hydroxyproline content respectively.
34474849	3	97	theme	doped	650:654	arg1	particles					675:683	chitosan and Si doped nanohydroxyapatite particles	634:683	chitosan and Si doped nanohydroxyapatite particles (Si-nHap)	634:693	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	3	97	theme	doped	650:654	arg1	Si-nHap					686:692	Si-nHap	686:692	Si-nHap	686:692	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	0	98	theme	bilayer	55:61	arg1	membranes					94:102	bilayer chitosan nanocomposite barrier membranes	55:102	bilayer chitosan nanocomposite barrier membranes	55:102	Development of Si doped nano hydroxyapatite reinforced bilayer chitosan nanocomposite barrier membranes for guided bone regeneration.
34474849	6	99	theme	SEM	1202:1204	arg1	study					1288:1292	SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study	1202:1292	SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study	1202:1292	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	4	100	theme	upper	863:867	arg1	layer					869:873	its upper layer	859:873	its upper layer	859:873	Bilayer membrane was designed to prevent epithelial and fibroblastic cell migration and growth impeding bone formation with its upper layer and to support osteogenic cell bioactivity at the defect site with its sublayer.
34474849	5	101	theme	electrospinning	1032:1046	arg1	techniques					1048:1057	freeze-drying and electrospinning techniques	1014:1057	freeze-drying and electrospinning techniques	1014:1057	Microporous and nanofiber layers were fabricated by using freeze-drying and electrospinning techniques respectively.
34474849	7	102	theme	membranes	1337:1345	arg1	properties					1309:1318	Antimicrobial properties	1295:1318	Antimicrobial properties of nanocomposite membranes	1295:1345	Antimicrobial properties of nanocomposite membranes were investigated with tube dilution and disk diffusion methods.
34474849	2	103	theme	GBR	359:361	arg1	designs					363:369	GBR designs	359:369	GBR designs	359:369	Recently GBR designs have focused on the development of resorbable natural polymer-based barrier membranes due to their biodegradability and excellent biocompatibility.
34474849	1	104	theme	defects	223:229	arg1	treatment					198:206	the treatment	194:206	the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration	194:347	Guided Bone Regeneration (GBR) is a widely used process for the treatment of periodontal defects to prevent the formation of surrounding soft tissue at the periodontal defect and to provide hard tissue regeneration.
34474849	6	105	theme	composites	1167:1176	arg1	properties					1149:1158	the morphological, mechanical and physical properties	1106:1158	the morphological, mechanical and physical properties of the composites	1106:1176	The effect of Si-nHap content on the morphological, mechanical and physical properties of the composites were investigated using SEM, AFM, micro-Ct, compression test, water uptake capacity and enzymatic degradation study.
34474849	10	106	theme	hydroxyproline	1629:1642	arg1	content					1644:1650	hydroxyproline content	1629:1650	hydroxyproline content	1629:1650	In vitro bioactivity of Saos-2 and NIH/3T3 cells were evaluated with ALP activity and hydroxyproline content respectively.
34474849	4	107	theme	bone	839:842	arg1	formation					844:852	bone formation	839:852	bone formation with its upper layer	839:873	Bilayer membrane was designed to prevent epithelial and fibroblastic cell migration and growth impeding bone formation with its upper layer and to support osteogenic cell bioactivity at the defect site with its sublayer.
34474849	3	108	theme	study	535:539	arg1	aim					523:525	The aim	519:525	The aim of this study	519:539	The aim of this study is to fabricate a novel bilayer nanocomposite membrane with microporous sublayer composed of chitosan and Si doped nanohydroxyapatite particles (Si-nHap) and chitosan/PEO nanofiber upper layer.
34474849	9	109	theme	proliferation	1489:1501	arg1	studies					1503:1509	NIH/3T3 proliferation studies	1481:1509	NIH/3T3 proliferation studies	1481:1509	Saos-2 and NIH/3T3 proliferation studies were carried out on each layer.
33641947	0	0	theme	physicochemical	55:69	arg1	properties					71:80	physicochemical properties	55:80	physicochemical properties	55:80	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	2	1	theme	glycation	449:457	arg1	inhibition					459:468	glycation inhibition	449:468	glycation inhibition	449:468	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	2	2	theme	succeeding	320:329	arg1	cooking					331:337	the succeeding cooking	316:337	the succeeding cooking	316:337	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	1	3	theme	Chinese	214:220	arg1	medicine					227:234	Chinese folk medicine	214:234	Chinese folk medicine	214:234	Black rice is recognized for managing diabetes in Chinese folk medicine.
33641947	6	4	dep	showed	968:973	arg1	whereas					1044:1050	whereas	1044:1050	whereas	1044:1050	The thermally treated grains showed pronounced activity against α-amylase, α-glucosidase, and glycation, whereas their cooked counterparts reduced the estimated glycemic index (eGI), and enhanced resistant starch (RS).
33641947	0	5	theme	type	147:150	arg1	diabetes					154:161	type 2 diabetes	147:161	type 2 diabetes	147:161	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	5	6	theme	frying	868:873	arg1	effect					858:863	the combined effect	845:863	the combined effect of frying and cooking	845:885	Additionally, the combined effect of frying and cooking diminished TFC, TPAC, and α-glucosidase inhibition.
33641947	2	7	from	effect	283:288	arg1	properties					369:378	black rice physicochemical properties	342:378	black rice physicochemical properties	342:378	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	2	7	from	effect	283:288	arg1	activity					421:428	total antioxidant activity	403:428	total antioxidant activity (TAA)	403:434	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	2	7	from	effect	283:288	arg1	inhibition					459:468	glycation inhibition	449:468	glycation inhibition	449:468	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	2	7	from	effect	283:288	arg1	composition					390:400	phenolic composition	381:400	phenolic composition	381:400	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	2	7	from	effect	283:288	arg1	TAA					431:433	TAA	431:433	TAA	431:433	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	2	7	from	effect	283:288	arg1	enzymes					437:443	enzymes	437:443	enzymes	437:443	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	1	8	theme	folk	222:225	arg1	medicine					227:234	Chinese folk medicine	214:234	Chinese folk medicine	214:234	Black rice is recognized for managing diabetes in Chinese folk medicine.
33641947	2	9	theme	present	252:258	arg1	study					260:264	the present study	248:264	the present study	248:264	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	6	10	theme	treated	953:959	arg1	grains					961:966	The thermally treated grains	939:966	The thermally treated grains	939:966	The thermally treated grains showed pronounced activity against α-amylase, α-glucosidase, and glycation, whereas their cooked counterparts reduced the estimated glycemic index (eGI), and enhanced resistant starch (RS).
33641947	0	11	theme	properties	71:80	arg1	functions					127:135	phenolic functions	118:135	phenolic functions	118:135	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	0	11	theme	properties	71:80	arg1	digestibility					99:111	in vitro starch digestibility	83:111	in vitro starch digestibility	83:111	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	0	11	theme	properties	71:80	arg1	Evaluation					41:50	Evaluation	41:50	Evaluation of physicochemical properties	41:80	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	0	11	theme	properties	71:80	arg1	processing					29:38	Black rice (Oryza sativa L.) processing	0:38	Black rice (Oryza sativa L.) processing	0:38	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	4	12	theme	total	759:763	arg1	phenolics					765:773	total phenolics	759:773	total phenolics (TPC)	759:779	Roasting of grains sustained total phenolics (TPC), flavonoids (TFC), TPAC, and antilipase activity.
33641947	4	12	theme	total	759:763	arg1	TPC					776:778	TPC	776:778	TPC	776:778	Roasting of grains sustained total phenolics (TPC), flavonoids (TFC), TPAC, and antilipase activity.
33641947	0	13	dep	in	83:84	arg1	vitro					86:90	vitro	86:90	vitro	86:90	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	8	14	theme	rice	1321:1324	arg1	processing					1326:1335	black rice processing	1315:1335	black rice processing	1315:1335	These findings are demonstrating that black rice processing is favorable for the dietary management of metabolic disorders such as diabetes and hyperlipidemia.
33641947	6	15	theme	resistant	1135:1143	arg1	RS					1153:1154	RS	1153:1154	RS	1153:1154	The thermally treated grains showed pronounced activity against α-amylase, α-glucosidase, and glycation, whereas their cooked counterparts reduced the estimated glycemic index (eGI), and enhanced resistant starch (RS).
33641947	6	15	theme	resistant	1135:1143	arg1	starch					1145:1150	resistant starch	1135:1150	resistant starch (RS)	1135:1155	The thermally treated grains showed pronounced activity against α-amylase, α-glucosidase, and glycation, whereas their cooked counterparts reduced the estimated glycemic index (eGI), and enhanced resistant starch (RS).
33641947	0	16	theme	in	83:84	arg1	digestibility					99:111	in vitro starch digestibility	83:111	in vitro starch digestibility	83:111	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	3	17	theme	Thermal	507:513	arg1	decomposition					515:527	Thermal decomposition	507:527	Thermal decomposition of anthocyanin and cyanidin-3-glucoside	507:567	Thermal decomposition of anthocyanin and cyanidin-3-glucoside was evident across all processing methods and reflected in increasing levels of protocatechuic acid, while proanthocyanidins (TPAC) were susceptible to cooking.
33641947	6	18	theme	cooked	1058:1063	arg1	counterparts					1065:1076	their cooked counterparts	1052:1076	their cooked counterparts	1052:1076	The thermally treated grains showed pronounced activity against α-amylase, α-glucosidase, and glycation, whereas their cooked counterparts reduced the estimated glycemic index (eGI), and enhanced resistant starch (RS).
33641947	2	19	theme	physicochemical	353:367	arg1	properties					369:378	black rice physicochemical properties	342:378	black rice physicochemical properties	342:378	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	0	20	theme	rice	6:9	arg1	processing					29:38	Black rice (Oryza sativa L.) processing	0:38	Black rice (Oryza sativa L.) processing	0:38	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	3	21	theme	cyanidin-3-glucoside	548:567	arg1	decomposition					515:527	Thermal decomposition	507:527	Thermal decomposition of anthocyanin and cyanidin-3-glucoside	507:567	Thermal decomposition of anthocyanin and cyanidin-3-glucoside was evident across all processing methods and reflected in increasing levels of protocatechuic acid, while proanthocyanidins (TPAC) were susceptible to cooking.
33641947	2	22	theme	rice	348:351	arg1	properties					369:378	black rice physicochemical properties	342:378	black rice physicochemical properties	342:378	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	0	23	theme	Black	0:4	arg1	Oryza					12:16	Oryza	12:16	Oryza	12:16	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	0	23	theme	Black	0:4	arg1	rice					6:9	Black rice	0:9	Black rice (Oryza sativa L.) processing	0:38	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	4	24	theme	antilipase	810:819	arg1	activity					821:828	antilipase activity	810:828	antilipase activity	810:828	Roasting of grains sustained total phenolics (TPC), flavonoids (TFC), TPAC, and antilipase activity.
33641947	8	25	theme	black	1315:1319	arg1	processing					1326:1335	black rice processing	1315:1335	black rice processing	1315:1335	These findings are demonstrating that black rice processing is favorable for the dietary management of metabolic disorders such as diabetes and hyperlipidemia.
33641947	2	26	theme	black	342:346	arg1	properties					369:378	black rice physicochemical properties	342:378	black rice physicochemical properties	342:378	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	2	27	theme	antioxidant	409:419	arg1	activity					421:428	total antioxidant activity	403:428	total antioxidant activity (TAA)	403:434	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	2	27	theme	antioxidant	409:419	arg1	TAA					431:433	TAA	431:433	TAA	431:433	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	7	28	dep	grains	1168:1173	arg1	chrominance					1175:1185	chrominance	1175:1185	chrominance	1175:1185	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	7	28	dep	grains	1168:1173	arg1	AAC					1223:1225	AAC	1223:1225	AAC	1223:1225	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	7	28	dep	grains	1168:1173	arg1	grains					1168:1173	Processed grains chrominance, TAA, and apparent amylose content (AAC)	1158:1226	Processed grains chrominance, TAA, and apparent amylose content (AAC)	1158:1226	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	7	28	dep	grains	1168:1173	arg1	content					1214:1220	apparent amylose content	1197:1220	apparent amylose content (AAC)	1197:1226	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	7	28	dep	grains	1168:1173	arg1	TAA					1188:1190	TAA	1188:1190	TAA	1188:1190	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	3	29	theme	anthocyanin	532:542	arg1	decomposition					515:527	Thermal decomposition	507:527	Thermal decomposition of anthocyanin and cyanidin-3-glucoside	507:567	Thermal decomposition of anthocyanin and cyanidin-3-glucoside was evident across all processing methods and reflected in increasing levels of protocatechuic acid, while proanthocyanidins (TPAC) were susceptible to cooking.
33641947	1	30	theme	Black	164:168	arg1	rice					170:173	Black rice	164:173	Black rice	164:173	Black rice is recognized for managing diabetes in Chinese folk medicine.
33641947	2	31	theme	total	403:407	arg1	activity					421:428	total antioxidant activity	403:428	total antioxidant activity (TAA)	403:434	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	2	31	theme	total	403:407	arg1	TAA					431:433	TAA	431:433	TAA	431:433	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	0	32	theme	starch	92:97	arg1	digestibility					99:111	in vitro starch digestibility	83:111	in vitro starch digestibility	83:111	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	4	33	theme	grains	742:747	arg1	Roasting					730:737	Roasting	730:737	Roasting of grains	730:747	Roasting of grains sustained total phenolics (TPC), flavonoids (TFC), TPAC, and antilipase activity.
33641947	0	34	attach	linked	137:142	arg1	diabetes					154:161	type 2 diabetes	147:161	type 2 diabetes	147:161	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	0	34	attach	linked	137:142	arg2	processing					29:38	Black rice (Oryza sativa L.) processing	0:38	Black rice (Oryza sativa L.) processing	0:38	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	0	34	attach	linked	137:142	arg2	functions					127:135	phenolic functions	118:135	phenolic functions	118:135	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	0	34	attach	linked	137:142	arg2	Evaluation					41:50	Evaluation	41:50	Evaluation of physicochemical properties	41:80	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	0	34	attach	linked	137:142	arg2	digestibility					99:111	in vitro starch digestibility	83:111	in vitro starch digestibility	83:111	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	7	35	theme	apparent	1197:1204	arg1	AAC					1223:1225	AAC	1223:1225	AAC	1223:1225	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	7	35	theme	apparent	1197:1204	arg1	grains					1168:1173	Processed grains chrominance, TAA, and apparent amylose content (AAC)	1158:1226	Processed grains chrominance, TAA, and apparent amylose content (AAC)	1158:1226	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	7	35	theme	apparent	1197:1204	arg1	content					1214:1220	apparent amylose content	1197:1220	apparent amylose content (AAC)	1197:1226	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	5	36	theme	cooking	879:885	arg1	effect					858:863	the combined effect	845:863	the combined effect of frying and cooking	845:885	Additionally, the combined effect of frying and cooking diminished TFC, TPAC, and α-glucosidase inhibition.
33641947	2	37	dep	digestibility	492:504	arg1	addition					473:480	addition	473:480	addition	473:480	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	3	38	theme	protocatechuic	649:662	arg1	acid					664:667	protocatechuic acid	649:667	protocatechuic acid	649:667	Thermal decomposition of anthocyanin and cyanidin-3-glucoside was evident across all processing methods and reflected in increasing levels of protocatechuic acid, while proanthocyanidins (TPAC) were susceptible to cooking.
33641947	2	39	theme	phenolic	381:388	arg1	composition					390:400	phenolic composition	381:400	phenolic composition	381:400	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	7	40	with	correlation	1249:1259	arg1	phenolics					1266:1274	phenolics	1266:1274	phenolics	1266:1274	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	3	41	theme	increasing	628:637	arg1	levels					639:644	increasing levels	628:644	increasing levels of protocatechuic acid	628:667	Thermal decomposition of anthocyanin and cyanidin-3-glucoside was evident across all processing methods and reflected in increasing levels of protocatechuic acid, while proanthocyanidins (TPAC) were susceptible to cooking.
33641947	3	42	theme	processing	592:601	arg1	methods					603:609	all processing methods	588:609	all processing methods	588:609	Thermal decomposition of anthocyanin and cyanidin-3-glucoside was evident across all processing methods and reflected in increasing levels of protocatechuic acid, while proanthocyanidins (TPAC) were susceptible to cooking.
33641947	1	43	from	diabetes	202:209	arg1	medicine					227:234	Chinese folk medicine	214:234	Chinese folk medicine	214:234	Black rice is recognized for managing diabetes in Chinese folk medicine.
33641947	8	44	theme	dietary	1358:1364	arg1	management					1366:1375	the dietary management	1354:1375	the dietary management of metabolic disorders such as diabetes and hyperlipidemia	1354:1434	These findings are demonstrating that black rice processing is favorable for the dietary management of metabolic disorders such as diabetes and hyperlipidemia.
33641947	0	45	theme	phenolic	118:125	arg1	functions					127:135	phenolic functions	118:135	phenolic functions	118:135	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	8	46	theme	metabolic	1380:1388	arg1	diabetes					1408:1415	diabetes	1408:1415	diabetes	1408:1415	These findings are demonstrating that black rice processing is favorable for the dietary management of metabolic disorders such as diabetes and hyperlipidemia.
33641947	8	46	theme	metabolic	1380:1388	arg1	hyperlipidemia					1421:1434	hyperlipidemia	1421:1434	hyperlipidemia	1421:1434	These findings are demonstrating that black rice processing is favorable for the dietary management of metabolic disorders such as diabetes and hyperlipidemia.
33641947	8	46	theme	metabolic	1380:1388	arg1	disorders					1390:1398	metabolic disorders	1380:1398	metabolic disorders such as diabetes and hyperlipidemia	1380:1434	These findings are demonstrating that black rice processing is favorable for the dietary management of metabolic disorders such as diabetes and hyperlipidemia.
33641947	7	47	theme	Processed	1158:1166	arg1	chrominance					1175:1185	chrominance	1175:1185	chrominance	1175:1185	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	7	47	theme	Processed	1158:1166	arg1	content					1214:1220	apparent amylose content	1197:1220	apparent amylose content (AAC)	1197:1226	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	7	47	theme	Processed	1158:1166	arg1	grains					1168:1173	Processed grains chrominance, TAA, and apparent amylose content (AAC)	1158:1226	Processed grains chrominance, TAA, and apparent amylose content (AAC)	1158:1226	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	7	47	theme	Processed	1158:1166	arg1	TAA					1188:1190	TAA	1188:1190	TAA	1188:1190	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	2	48	theme	treatments	301:310	arg1	effect					283:288	the effect	279:288	the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition	279:468	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	7	49	theme	amylose	1206:1212	arg1	AAC					1223:1225	AAC	1223:1225	AAC	1223:1225	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	7	49	theme	amylose	1206:1212	arg1	grains					1168:1173	Processed grains chrominance, TAA, and apparent amylose content (AAC)	1158:1226	Processed grains chrominance, TAA, and apparent amylose content (AAC)	1158:1226	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	7	49	theme	amylose	1206:1212	arg1	content					1214:1220	apparent amylose content	1197:1220	apparent amylose content (AAC)	1197:1226	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	0	50	dep	Oryza	12:16	arg1	L.					25:26	Oryza sativa L.	12:26	Oryza sativa L.	12:26	Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.
33641947	2	51	theme	thermal	293:299	arg1	treatments					301:310	thermal treatments	293:310	thermal treatments	293:310	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	3	52	theme	acid	664:667	arg1	levels					639:644	increasing levels	628:644	increasing levels of protocatechuic acid	628:667	Thermal decomposition of anthocyanin and cyanidin-3-glucoside was evident across all processing methods and reflected in increasing levels of protocatechuic acid, while proanthocyanidins (TPAC) were susceptible to cooking.
33641947	5	53	theme	α-glucosidase	913:925	arg1	inhibition					927:936	α-glucosidase inhibition	913:936	α-glucosidase inhibition	913:936	Additionally, the combined effect of frying and cooking diminished TFC, TPAC, and α-glucosidase inhibition.
33641947	6	54	theme	estimated	1090:1098	arg1	eGI					1116:1118	eGI	1116:1118	eGI	1116:1118	The thermally treated grains showed pronounced activity against α-amylase, α-glucosidase, and glycation, whereas their cooked counterparts reduced the estimated glycemic index (eGI), and enhanced resistant starch (RS).
33641947	6	54	theme	estimated	1090:1098	arg1	index					1109:1113	the estimated glycemic index	1086:1113	the estimated glycemic index (eGI)	1086:1119	The thermally treated grains showed pronounced activity against α-amylase, α-glucosidase, and glycation, whereas their cooked counterparts reduced the estimated glycemic index (eGI), and enhanced resistant starch (RS).
33641947	6	55	theme	glycemic	1100:1107	arg1	eGI					1116:1118	eGI	1116:1118	eGI	1116:1118	The thermally treated grains showed pronounced activity against α-amylase, α-glucosidase, and glycation, whereas their cooked counterparts reduced the estimated glycemic index (eGI), and enhanced resistant starch (RS).
33641947	6	55	theme	glycemic	1100:1107	arg1	index					1109:1113	the estimated glycemic index	1086:1113	the estimated glycemic index (eGI)	1086:1119	The thermally treated grains showed pronounced activity against α-amylase, α-glucosidase, and glycation, whereas their cooked counterparts reduced the estimated glycemic index (eGI), and enhanced resistant starch (RS).
33641947	8	56	theme	disorders	1390:1398	arg1	management					1366:1375	the dietary management	1354:1375	the dietary management of metabolic disorders such as diabetes and hyperlipidemia	1354:1434	These findings are demonstrating that black rice processing is favorable for the dietary management of metabolic disorders such as diabetes and hyperlipidemia.
33641947	7	57	theme	significant	1237:1247	arg1	correlation					1249:1259	a significant correlation	1235:1259	a significant correlation with phenolics	1235:1274	Processed grains chrominance, TAA, and apparent amylose content (AAC) showed a significant correlation with phenolics.
33641947	5	58	theme	combined	849:856	arg1	effect					858:863	the combined effect	845:863	the combined effect of frying and cooking	845:885	Additionally, the combined effect of frying and cooking diminished TFC, TPAC, and α-glucosidase inhibition.
33641947	6	59	theme	pronounced	975:984	arg1	activity					986:993	pronounced activity	975:993	pronounced activity against α-amylase, α-glucosidase, and glycation	975:1041	The thermally treated grains showed pronounced activity against α-amylase, α-glucosidase, and glycation, whereas their cooked counterparts reduced the estimated glycemic index (eGI), and enhanced resistant starch (RS).
33641947	2	60	theme	cooking	331:337	arg1	effect					283:288	the effect	279:288	the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition	279:468	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
33641947	2	61	theme	starch	485:490	arg1	digestibility					492:504	starch digestibility	485:504	starch digestibility	485:504	Therefore, the present study investigates the effect of thermal treatments and the succeeding cooking on black rice physicochemical properties, phenolic composition, total antioxidant activity (TAA), enzymes and glycation inhibition in addition to starch digestibility.
34089448	0	0	from	study	11:15	arg1	energy					20:25	energy	20:25	energy	20:25	A relative study on energy and exergy analysis between conventional single slope and novel stepped absorbable plate solar stills.
34089448	0	0	from	study	11:15	arg1	analysis					38:45	exergy analysis	31:45	exergy analysis	31:45	A relative study on energy and exergy analysis between conventional single slope and novel stepped absorbable plate solar stills.
34089448	7	1	dep	December	1036:1043	arg1	to					1045:1046	to	1045:1046	to	1045:1046	The experimental setup was performed through the period from December to February 2020 in the Indian climatic condition.
34089448	7	1	dep	December	1036:1043	arg1	February					1048:1055	February	1048:1055	February	1048:1055	The experimental setup was performed through the period from December to February 2020 in the Indian climatic condition.
34089448	3	2	theme	shrimp	472:477	arg1	shells					479:484	waste shrimp shells	466:484	waste shrimp shells	466:484	The absorbing material is composed of chitosan (obtained from waste shrimp shells), ethylene diamine tetraacetic acid (EDTA), and Chrysopogon zizaniodes (Vetiver).
34089448	1	3	theme	many	240:243	arg1	researches					245:254	many researches	240:254	many researches	240:254	The innovation of novel absorbing materials using composite materials and nanotechnology is of new trends for many researches.
34089448	0	4	theme	single	68:73	arg1	slope					75:79	conventional single slope	55:79	conventional single slope	55:79	A relative study on energy and exergy analysis between conventional single slope and novel stepped absorbable plate solar stills.
34089448	6	5	theme	present	813:819	arg1	study					821:825	this present study	808:825	this present study	808:825	In this present study, the PSS is compared with the conventional solar still (CSS) for the use of assessing the yield of freshwater in the same atmospheric circumstance.
34089448	1	6	theme	novel	148:152	arg1	materials					164:172	novel absorbing materials	148:172	novel absorbing materials using composite materials and nanotechnology	148:217	The innovation of novel absorbing materials using composite materials and nanotechnology is of new trends for many researches.
34089448	10	7	theme	PSS	1329:1331	arg1	efficiency					1311:1320	The energy efficiency	1300:1320	The energy efficiency of the PSS	1300:1331	The energy efficiency of the PSS is 18.34% and the exergy efficiency is 0.45%.
34089448	10	7	theme	PSS	1329:1331	arg1	%					1341:1341	18.34%	1336:1341	18.34%	1336:1341	The energy efficiency of the PSS is 18.34% and the exergy efficiency is 0.45%.
34089448	0	8	theme	novel	85:89	arg1	stills					122:127	novel stepped absorbable plate solar stills	85:127	novel stepped absorbable plate solar stills	85:127	A relative study on energy and exergy analysis between conventional single slope and novel stepped absorbable plate solar stills.
34089448	7	9	theme	experimental	979:990	arg1	setup					992:996	The experimental setup	975:996	The experimental setup	975:996	The experimental setup was performed through the period from December to February 2020 in the Indian climatic condition.
34089448	3	10	theme	tetraacetic	505:515	arg1	EDTA					523:526	EDTA	523:526	EDTA	523:526	The absorbing material is composed of chitosan (obtained from waste shrimp shells), ethylene diamine tetraacetic acid (EDTA), and Chrysopogon zizaniodes (Vetiver).
34089448	3	10	theme	tetraacetic	505:515	arg1	acid					517:520	ethylene diamine tetraacetic acid	488:520	ethylene diamine tetraacetic acid (EDTA)	488:527	The absorbing material is composed of chitosan (obtained from waste shrimp shells), ethylene diamine tetraacetic acid (EDTA), and Chrysopogon zizaniodes (Vetiver).
34089448	7	11	theme	climatic	1076:1083	arg1	condition					1085:1093	the Indian climatic condition	1065:1093	the Indian climatic condition	1065:1093	The experimental setup was performed through the period from December to February 2020 in the Indian climatic condition.
34089448	7	12	from	December	1036:1043	arg1	period					1024:1029	the period	1020:1029	the period from December to February 2020 in the Indian climatic condition	1020:1093	The experimental setup was performed through the period from December to February 2020 in the Indian climatic condition.
34089448	2	13	theme	present	267:273	arg1	study					275:279	the present study	263:279	the present study	263:279	Here, the present study is concerning to enhance the distilled water productivity of a proposed solar still (PSS) using novel absorbing materials.
34089448	0	14	theme	absorbable	99:108	arg1	stills					122:127	novel stepped absorbable plate solar stills	85:127	novel stepped absorbable plate solar stills	85:127	A relative study on energy and exergy analysis between conventional single slope and novel stepped absorbable plate solar stills.
34089448	6	15	theme	same	944:947	arg1	circumstance					961:972	the same atmospheric circumstance	940:972	the same atmospheric circumstance	940:972	In this present study, the PSS is compared with the conventional solar still (CSS) for the use of assessing the yield of freshwater in the same atmospheric circumstance.
34089448	3	16	theme	ethylene	488:495	arg1	EDTA					523:526	EDTA	523:526	EDTA	523:526	The absorbing material is composed of chitosan (obtained from waste shrimp shells), ethylene diamine tetraacetic acid (EDTA), and Chrysopogon zizaniodes (Vetiver).
34089448	3	16	theme	ethylene	488:495	arg1	acid					517:520	ethylene diamine tetraacetic acid	488:520	ethylene diamine tetraacetic acid (EDTA)	488:527	The absorbing material is composed of chitosan (obtained from waste shrimp shells), ethylene diamine tetraacetic acid (EDTA), and Chrysopogon zizaniodes (Vetiver).
34089448	1	17	theme	absorbing	154:162	arg1	materials					164:172	novel absorbing materials	148:172	novel absorbing materials using composite materials and nanotechnology	148:217	The innovation of novel absorbing materials using composite materials and nanotechnology is of new trends for many researches.
34089448	0	18	theme	stepped	91:97	arg1	stills					122:127	novel stepped absorbable plate solar stills	85:127	novel stepped absorbable plate solar stills	85:127	A relative study on energy and exergy analysis between conventional single slope and novel stepped absorbable plate solar stills.
34089448	3	19	theme	diamine	497:503	arg1	EDTA					523:526	EDTA	523:526	EDTA	523:526	The absorbing material is composed of chitosan (obtained from waste shrimp shells), ethylene diamine tetraacetic acid (EDTA), and Chrysopogon zizaniodes (Vetiver).
34089448	3	19	theme	diamine	497:503	arg1	acid					517:520	ethylene diamine tetraacetic acid	488:520	ethylene diamine tetraacetic acid (EDTA)	488:527	The absorbing material is composed of chitosan (obtained from waste shrimp shells), ethylene diamine tetraacetic acid (EDTA), and Chrysopogon zizaniodes (Vetiver).
34089448	1	20	theme	materials	164:172	arg1	innovation					134:143	The innovation	130:143	The innovation of novel absorbing materials using composite materials and nanotechnology	130:217	The innovation of novel absorbing materials using composite materials and nanotechnology is of new trends for many researches.
34089448	0	21	theme	relative	2:9	arg1	study					11:15	A relative study	0:15	A relative study on energy and exergy analysis between conventional single slope and novel stepped absorbable plate solar stills.	0:128	A relative study on energy and exergy analysis between conventional single slope and novel stepped absorbable plate solar stills.
34089448	10	22	theme	energy	1304:1309	arg1	efficiency					1311:1320	The energy efficiency	1300:1320	The energy efficiency of the PSS	1300:1331	The energy efficiency of the PSS is 18.34% and the exergy efficiency is 0.45%.
34089448	10	22	theme	energy	1304:1309	arg1	%					1341:1341	18.34%	1336:1341	18.34%	1336:1341	The energy efficiency of the PSS is 18.34% and the exergy efficiency is 0.45%.
34089448	7	23	from	period	1024:1029	arg1	condition					1085:1093	the Indian climatic condition	1065:1093	the Indian climatic condition	1065:1093	The experimental setup was performed through the period from December to February 2020 in the Indian climatic condition.
34089448	9	24	from	increase	1197:1204	arg1	efficiency					1209:1218	efficiency	1209:1218	efficiency	1209:1218	The increase in efficiency obtained from a PSS is 39.71% more than the productivity attained from the CSS.
34089448	1	25	theme	composite	180:188	arg1	materials					190:198	composite materials	180:198	composite materials	180:198	The innovation of novel absorbing materials using composite materials and nanotechnology is of new trends for many researches.
34089448	6	26	theme	conventional	857:868	arg1	CSS					883:885	CSS	883:885	CSS	883:885	In this present study, the PSS is compared with the conventional solar still (CSS) for the use of assessing the yield of freshwater in the same atmospheric circumstance.
34089448	6	26	theme	conventional	857:868	arg1	solar					870:874	the conventional solar	853:874	the conventional solar still (CSS) for the use of assessing the yield of freshwater in the same atmospheric circumstance	853:972	In this present study, the PSS is compared with the conventional solar still (CSS) for the use of assessing the yield of freshwater in the same atmospheric circumstance.
34089448	0	27	theme	solar	116:120	arg1	stills					122:127	novel stepped absorbable plate solar stills	85:127	novel stepped absorbable plate solar stills	85:127	A relative study on energy and exergy analysis between conventional single slope and novel stepped absorbable plate solar stills.
34089448	0	28	theme	plate	110:114	arg1	stills					122:127	novel stepped absorbable plate solar stills	85:127	novel stepped absorbable plate solar stills	85:127	A relative study on energy and exergy analysis between conventional single slope and novel stepped absorbable plate solar stills.
34089448	6	29	theme	atmospheric	949:959	arg1	circumstance					961:972	the same atmospheric circumstance	940:972	the same atmospheric circumstance	940:972	In this present study, the PSS is compared with the conventional solar still (CSS) for the use of assessing the yield of freshwater in the same atmospheric circumstance.
34089448	2	30	theme	absorbing	383:391	arg1	materials					393:401	novel absorbing materials	377:401	novel absorbing materials	377:401	Here, the present study is concerning to enhance the distilled water productivity of a proposed solar still (PSS) using novel absorbing materials.
34089448	7	31	theme	Indian	1069:1074	arg1	condition					1085:1093	the Indian climatic condition	1065:1093	the Indian climatic condition	1065:1093	The experimental setup was performed through the period from December to February 2020 in the Indian climatic condition.
34089448	3	32	theme	waste	466:470	arg1	shells					479:484	waste shrimp shells	466:484	waste shrimp shells	466:484	The absorbing material is composed of chitosan (obtained from waste shrimp shells), ethylene diamine tetraacetic acid (EDTA), and Chrysopogon zizaniodes (Vetiver).
34089448	6	33	from	solar	870:874	arg1	study					821:825	this present study	808:825	this present study	808:825	In this present study, the PSS is compared with the conventional solar still (CSS) for the use of assessing the yield of freshwater in the same atmospheric circumstance.
34089448	4	34	theme	materials	593:601	arg1	combination					572:582	The combination	568:582	The combination of these materials	568:601	The combination of these materials is coined as CHEDZ, and it acts as a super absorbent polymer that is coated on the stepped solar still.
34089448	4	34	theme	materials	593:601	arg1	CHEDZ					616:620	CHEDZ	616:620	CHEDZ	616:620	The combination of these materials is coined as CHEDZ, and it acts as a super absorbent polymer that is coated on the stepped solar still.
34089448	6	35	theme	freshwater	926:935	arg1	yield					917:921	the yield	913:921	the yield of freshwater	913:935	In this present study, the PSS is compared with the conventional solar still (CSS) for the use of assessing the yield of freshwater in the same atmospheric circumstance.
34089448	2	36	theme	novel	377:381	arg1	materials					393:401	novel absorbing materials	377:401	novel absorbing materials	377:401	Here, the present study is concerning to enhance the distilled water productivity of a proposed solar still (PSS) using novel absorbing materials.
34089448	3	37	theme	absorbing	408:416	arg1	material					418:425	The absorbing material	404:425	The absorbing material	404:425	The absorbing material is composed of chitosan (obtained from waste shrimp shells), ethylene diamine tetraacetic acid (EDTA), and Chrysopogon zizaniodes (Vetiver).
34089448	5	38	theme	Evaporation	707:717	arg1	rate					719:722	Evaporation rate	707:722	Evaporation rate	707:722	Evaporation rate increases due to this absorbent, which further increases the yield of the still.
34089448	5	39	theme	the	794:796	arg1	yield					785:789	the yield	781:789	the yield of the	781:796	Evaporation rate increases due to this absorbent, which further increases the yield of the still.
34089448	10	40	theme	exergy	1351:1356	arg1	efficiency					1358:1367	the exergy efficiency	1347:1367	the exergy efficiency	1347:1367	The energy efficiency of the PSS is 18.34% and the exergy efficiency is 0.45%.
34089448	10	40	theme	exergy	1351:1356	arg1	%					1376:1376	0.45%	1372:1376	0.45%	1372:1376	The energy efficiency of the PSS is 18.34% and the exergy efficiency is 0.45%.
34089448	0	41	theme	exergy	31:36	arg1	analysis					38:45	exergy analysis	31:45	exergy analysis	31:45	A relative study on energy and exergy analysis between conventional single slope and novel stepped absorbable plate solar stills.
34089448	3	42	theme	Chrysopogon	534:544	arg1	zizaniodes					546:555	Chrysopogon zizaniodes	534:555	Chrysopogon zizaniodes (Vetiver)	534:565	The absorbing material is composed of chitosan (obtained from waste shrimp shells), ethylene diamine tetraacetic acid (EDTA), and Chrysopogon zizaniodes (Vetiver).
34089448	3	42	theme	Chrysopogon	534:544	arg1	Vetiver					558:564	Vetiver	558:564	Vetiver	558:564	The absorbing material is composed of chitosan (obtained from waste shrimp shells), ethylene diamine tetraacetic acid (EDTA), and Chrysopogon zizaniodes (Vetiver).
34089448	2	43	theme	water	320:324	arg1	productivity					326:337	the distilled water productivity	306:337	the distilled water productivity of a proposed solar	306:357	Here, the present study is concerning to enhance the distilled water productivity of a proposed solar still (PSS) using novel absorbing materials.
34089448	4	44	theme	absorbent	646:654	arg1	it					627:628	it	627:628	it	627:628	The combination of these materials is coined as CHEDZ, and it acts as a super absorbent polymer that is coated on the stepped solar still.
34089448	4	44	theme	absorbent	646:654	arg1	polymer					656:662	a super absorbent polymer	638:662	a super absorbent polymer that is coated on the stepped solar still	638:704	The combination of these materials is coined as CHEDZ, and it acts as a super absorbent polymer that is coated on the stepped solar still.
34089448	2	45	theme	distilled	310:318	arg1	productivity					326:337	the distilled water productivity	306:337	the distilled water productivity of a proposed solar	306:357	Here, the present study is concerning to enhance the distilled water productivity of a proposed solar still (PSS) using novel absorbing materials.
34089448	4	46	theme	stepped	686:692	arg1	solar					694:698	the stepped solar	682:698	the stepped solar	682:698	The combination of these materials is coined as CHEDZ, and it acts as a super absorbent polymer that is coated on the stepped solar still.
34089448	6	47	dep	solar	870:874	arg1	is					836:837	is	836:837	is compared with the conventional solar still (CSS) for the use of assessing the yield of freshwater in the same atmospheric circumstance	836:972	In this present study, the PSS is compared with the conventional solar still (CSS) for the use of assessing the yield of freshwater in the same atmospheric circumstance.
34089448	2	48	dep	still	359:363	arg1	PSS					366:368	PSS	366:368	PSS	366:368	Here, the present study is concerning to enhance the distilled water productivity of a proposed solar still (PSS) using novel absorbing materials.
34089448	4	49	theme	super	640:644	arg1	it					627:628	it	627:628	it	627:628	The combination of these materials is coined as CHEDZ, and it acts as a super absorbent polymer that is coated on the stepped solar still.
34089448	4	49	theme	super	640:644	arg1	polymer					656:662	a super absorbent polymer	638:662	a super absorbent polymer that is coated on the stepped solar still	638:704	The combination of these materials is coined as CHEDZ, and it acts as a super absorbent polymer that is coated on the stepped solar still.
34089448	1	50	theme	new	225:227	arg1	trends					229:234	new trends	225:234	new trends for many researches	225:254	The innovation of novel absorbing materials using composite materials and nanotechnology is of new trends for many researches.
34089448	0	51	theme	conventional	55:66	arg1	slope					75:79	conventional single slope	55:79	conventional single slope	55:79	A relative study on energy and exergy analysis between conventional single slope and novel stepped absorbable plate solar stills.
34089448	2	52	theme	solar	353:357	arg1	productivity					326:337	the distilled water productivity	306:337	the distilled water productivity of a proposed solar	306:357	Here, the present study is concerning to enhance the distilled water productivity of a proposed solar still (PSS) using novel absorbing materials.
34089448	8	53	theme	CSS	1174:1176	arg1	yield					1161:1165	the yield	1157:1165	the yield of the CSS	1157:1176	The freshwater productivity was improved to 3.05 L/day while the yield of the CSS is 2.47 L/day.
34089448	8	53	theme	CSS	1174:1176	arg1	L/day					1186:1190	2.47 L/day	1181:1190	2.47 L/day	1181:1190	The freshwater productivity was improved to 3.05 L/day while the yield of the CSS is 2.47 L/day.
34089448	8	54	theme	freshwater	1100:1109	arg1	productivity					1111:1122	The freshwater productivity	1096:1122	The freshwater productivity	1096:1122	The freshwater productivity was improved to 3.05 L/day while the yield of the CSS is 2.47 L/day.
34089448	2	55	theme	proposed	344:351	arg1	solar					353:357	a proposed solar	342:357	a proposed solar	342:357	Here, the present study is concerning to enhance the distilled water productivity of a proposed solar still (PSS) using novel absorbing materials.
32741761	4	0	theme	mechanisms	955:964	arg1	operation					928:936	The operation	924:936	The operation of physisorption mechanisms	924:964	The operation of physisorption mechanisms was supported by the obtained adsorption energies from D-R model that are less than 8 kJ/mol as well as the calculated free energies and enthalpies.
32741761	2	1	with	capacities	461:470	arg1	capacities					588:597	predicted maximum capacities	570:597	predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate)	570:665	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	2	1	with	capacities	461:470	arg1	values					490:495	experimental values	477:495	experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate)	477:563	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	4	2	from	model	1025:1029	arg1	energies					1007:1014	the obtained adsorption energies	983:1014	the obtained adsorption energies from D-R model that are less than 8 kJ/mol as well as the calculated free energies and enthalpies	983:1112	The operation of physisorption mechanisms was supported by the obtained adsorption energies from D-R model that are less than 8 kJ/mol as well as the calculated free energies and enthalpies.
32741761	3	3	theme	nonlinear	822:830	arg1	fitting					832:838	both the linear and nonlinear fitting	802:838	fitting	832:838	The adsorption systems for the three species follow the Freundlich isotherm model and Pseudo-First order as kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type.
32741761	2	4	theme	experimental	477:488	arg1	values					490:495	experimental values	477:495	experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate)	477:563	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	1	5	theme	different	342:350	arg1	species					352:358	different species	342:358	different species of water pollutants (Cd2+, safranin dye, and phosphate)	342:414	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	0	6	theme	bentonite	143:151	arg1	structure					119:127	a novel structure	111:127	a novel structure of exfoliated bentonite admixed with cellulose nanofiber	111:184	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	5	7	theme	exothermic	1232:1241	arg1	reactions					1271:1279	exothermic, favorable, and spontaneous reactions	1232:1279	exothermic, favorable, and spontaneous reactions	1232:1279	The thermodynamic investigation revealed the nature of the adsorption reactions of the three pollutants by EXB/CF as exothermic, favorable, and spontaneous reactions.
32741761	5	7	theme	exothermic	1232:1241	arg1	nature					1160:1165	the nature	1156:1165	the nature of the adsorption reactions of the three pollutants	1156:1217	The thermodynamic investigation revealed the nature of the adsorption reactions of the three pollutants by EXB/CF as exothermic, favorable, and spontaneous reactions.
32741761	5	8	theme	adsorption	1174:1183	arg1	reactions					1185:1193	the adsorption reactions	1170:1193	the adsorption reactions of the three pollutants	1170:1217	The thermodynamic investigation revealed the nature of the adsorption reactions of the three pollutants by EXB/CF as exothermic, favorable, and spontaneous reactions.
32741761	0	9	theme	cellulose	166:174	arg1	nanofiber					176:184	cellulose nanofiber	166:184	cellulose nanofiber	166:184	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	3	10	theme	linear	811:816	arg1	fitting					832:838	both the linear and nonlinear fitting	802:838	fitting	832:838	The adsorption systems for the three species follow the Freundlich isotherm model and Pseudo-First order as kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type.
32741761	4	11	theme	physisorption	941:953	arg1	mechanisms					955:964	physisorption mechanisms	941:964	physisorption mechanisms	941:964	The operation of physisorption mechanisms was supported by the obtained adsorption energies from D-R model that are less than 8 kJ/mol as well as the calculated free energies and enthalpies.
32741761	0	12	theme	safranin	76:83	arg1	dye					85:87	safranin dye	76:87	safranin dye	76:87	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	0	12	theme	safranin	76:83	arg1	pollutants					58:67	water pollutants	52:67	water pollutants (Cd2+, safranin dye, and phosphate)	52:103	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	3	13	theme	multilayer	872:881	arg1	uptake					883:888	multilayer uptake	872:888	multilayer uptake	872:888	The adsorption systems for the three species follow the Freundlich isotherm model and Pseudo-First order as kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type.
32741761	3	14	theme	heterogeneous	854:866	arg1	properties					890:899	heterogeneous and multilayer uptake properties	854:899	heterogeneous and multilayer uptake properties of physisorption type	854:921	The adsorption systems for the three species follow the Freundlich isotherm model and Pseudo-First order as kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type.
32741761	3	15	theme	Pseudo-First	754:765	arg1	order					767:771	Pseudo-First order	754:771	Pseudo-First order	754:771	The adsorption systems for the three species follow the Freundlich isotherm model and Pseudo-First order as kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type.
32741761	6	16	theme	recyclability	1326:1338	arg1	value					1340:1344	significant recyclability value	1314:1344	significant recyclability value	1314:1344	The EXB/CF composite also is of significant recyclability value and applied in five decontamination reusing runs for Cd2+, safranin dye, and phosphate achieving promising removal percentages.
32741761	1	17	theme	water	363:367	arg1	phosphate					405:413	phosphate	405:413	phosphate	405:413	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	17	theme	water	363:367	arg1	Cd2+					381:384	Cd2+	381:384	Cd2+	381:384	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	17	theme	water	363:367	arg1	dye					396:398	safranin dye	387:398	safranin dye	387:398	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	17	theme	water	363:367	arg1	pollutants					369:378	water pollutants	363:378	water pollutants (Cd2+, safranin dye, and phosphate)	363:414	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	2	18	theme	212.9 mg/g	602:611	arg1	capacities					588:597	predicted maximum capacities	570:597	predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate)	570:665	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	2	18	theme	212.9 mg/g	602:611	arg1	values					490:495	experimental values	477:495	experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate)	477:563	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	4	19	theme	free	1085:1088	arg1	energies					1090:1097	the calculated free energies	1070:1097	the calculated free energies	1070:1097	The operation of physisorption mechanisms was supported by the obtained adsorption energies from D-R model that are less than 8 kJ/mol as well as the calculated free energies and enthalpies.
32741761	6	20	theme	reusing	1382:1388	arg1	runs					1390:1393	five decontamination reusing runs	1361:1393	five decontamination reusing runs for Cd2+, safranin dye, and phosphate achieving promising removal percentages	1361:1471	The EXB/CF composite also is of significant recyclability value and applied in five decontamination reusing runs for Cd2+, safranin dye, and phosphate achieving promising removal percentages.
32741761	1	21	theme	pollutants	369:378	arg1	species					352:358	different species	342:358	different species of water pollutants (Cd2+, safranin dye, and phosphate)	342:414	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	6	22	theme	significant	1314:1324	arg1	value					1340:1344	significant recyclability value	1314:1344	significant recyclability value	1314:1344	The EXB/CF composite also is of significant recyclability value and applied in five decontamination reusing runs for Cd2+, safranin dye, and phosphate achieving promising removal percentages.
32741761	4	23	theme	obtained	987:994	arg1	energies					1007:1014	the obtained adsorption energies	983:1014	the obtained adsorption energies from D-R model that are less than 8 kJ/mol as well as the calculated free energies and enthalpies	983:1112	The operation of physisorption mechanisms was supported by the obtained adsorption energies from D-R model that are less than 8 kJ/mol as well as the calculated free energies and enthalpies.
32741761	5	24	theme	thermodynamic	1119:1131	arg1	investigation					1133:1145	The thermodynamic investigation	1115:1145	The thermodynamic investigation	1115:1145	The thermodynamic investigation revealed the nature of the adsorption reactions of the three pollutants by EXB/CF as exothermic, favorable, and spontaneous reactions.
32741761	2	25	theme	achieved	431:438	arg1	capacities					461:470	The composite achieved promising adsorption capacities	417:470	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).	417:666	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	3	26	theme	adsorption	672:681	arg1	systems					683:689	The adsorption systems	668:689	The adsorption systems for the three species	668:711	The adsorption systems for the three species follow the Freundlich isotherm model and Pseudo-First order as kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type.
32741761	2	27	theme	maximum	580:586	arg1	capacities					588:597	predicted maximum capacities	570:597	predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate)	570:665	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	6	28	theme	decontamination	1366:1380	arg1	runs					1390:1393	five decontamination reusing runs	1361:1393	five decontamination reusing runs for Cd2+, safranin dye, and phosphate achieving promising removal percentages	1361:1471	The EXB/CF composite also is of significant recyclability value and applied in five decontamination reusing runs for Cd2+, safranin dye, and phosphate achieving promising removal percentages.
32741761	2	29	theme	296 mg/g	544:551	arg1	capacities					588:597	predicted maximum capacities	570:597	predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate)	570:665	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	2	29	theme	296 mg/g	544:551	arg1	values					490:495	experimental values	477:495	experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate)	477:563	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	2	30	theme	composite	421:429	arg1	capacities					461:470	The composite achieved promising adsorption capacities	417:470	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).	417:666	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	2	31	theme	predicted	570:578	arg1	capacities					588:597	predicted maximum capacities	570:597	predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate)	570:665	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	2	32	theme	341 mg/g	621:628	arg1	capacities					588:597	predicted maximum capacities	570:597	predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate)	570:665	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	2	32	theme	341 mg/g	621:628	arg1	values					490:495	experimental values	477:495	experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate)	477:563	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	6	33	theme	safranin	1405:1412	arg1	dye					1414:1416	safranin dye	1405:1416	safranin dye	1405:1416	The EXB/CF composite also is of significant recyclability value and applied in five decontamination reusing runs for Cd2+, safranin dye, and phosphate achieving promising removal percentages.
32741761	0	34	dep	pollutants	58:67	arg1	Cd2+					70:73	Cd2+	70:73	Cd2+	70:73	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	0	34	dep	pollutants	58:67	arg1	dye					85:87	safranin dye	76:87	safranin dye	76:87	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	0	34	dep	pollutants	58:67	arg1	phosphate					94:102	phosphate	94:102	phosphate	94:102	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	0	34	dep	pollutants	58:67	arg1	pollutants					58:67	water pollutants	52:67	water pollutants (Cd2+, safranin dye, and phosphate)	52:103	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	2	35	theme	adsorption	450:459	arg1	capacities					461:470	The composite achieved promising adsorption capacities	417:470	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).	417:666	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	0	36	theme	types	43:47	arg1	decontamination					14:28	the decontamination	10:28	the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate)	10:103	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	1	37	theme	advanced	276:283	arg1	sheets					208:213	Exfoliated bentonite sheets	187:213	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF)	187:257	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	37	theme	advanced	276:283	arg1	properties					327:336	enhanced decontamination properties	302:336	enhanced decontamination properties	302:336	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	37	theme	advanced	276:283	arg1	bio-composite					285:297	advanced bio-composite	276:297	advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate)	276:414	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	3	38	theme	uptake	883:888	arg1	properties					890:899	heterogeneous and multilayer uptake properties	854:899	heterogeneous and multilayer uptake properties of physisorption type	854:921	The adsorption systems for the three species follow the Freundlich isotherm model and Pseudo-First order as kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type.
32741761	1	39	theme	Exfoliated	187:196	arg1	sheets					208:213	Exfoliated bentonite sheets	187:213	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF)	187:257	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	39	theme	Exfoliated	187:196	arg1	properties					327:336	enhanced decontamination properties	302:336	enhanced decontamination properties	302:336	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	39	theme	Exfoliated	187:196	arg1	bio-composite					285:297	advanced bio-composite	276:297	advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate)	276:414	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	0	40	theme	different	33:41	arg1	types					43:47	different types	33:47	different types of water pollutants (Cd2+, safranin dye, and phosphate)	33:103	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	1	41	dep	pollutants	369:378	arg1	pollutants					369:378	water pollutants	363:378	water pollutants (Cd2+, safranin dye, and phosphate)	363:414	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	41	dep	pollutants	369:378	arg1	Cd2+					381:384	Cd2+	381:384	Cd2+	381:384	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	41	dep	pollutants	369:378	arg1	dye					396:398	safranin dye	387:398	safranin dye	387:398	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	41	dep	pollutants	369:378	arg1	phosphate					405:413	phosphate	405:413	phosphate	405:413	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	2	42	theme	336 mg/g	519:526	arg1	capacities					588:597	predicted maximum capacities	570:597	predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate)	570:665	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	2	42	theme	336 mg/g	519:526	arg1	values					490:495	experimental values	477:495	experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate)	477:563	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	1	43	theme	safranin	387:394	arg1	dye					396:398	safranin dye	387:398	safranin dye	387:398	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	43	theme	safranin	387:394	arg1	pollutants					369:378	water pollutants	363:378	water pollutants (Cd2+, safranin dye, and phosphate)	363:414	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	2	44	theme	305 mg/g	646:653	arg1	capacities					588:597	predicted maximum capacities	570:597	predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate)	570:665	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	2	44	theme	305 mg/g	646:653	arg1	values					490:495	experimental values	477:495	experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate)	477:563	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	1	45	theme	bentonite	198:206	arg1	sheets					208:213	Exfoliated bentonite sheets	187:213	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF)	187:257	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	45	theme	bentonite	198:206	arg1	properties					327:336	enhanced decontamination properties	302:336	enhanced decontamination properties	302:336	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	45	theme	bentonite	198:206	arg1	bio-composite					285:297	advanced bio-composite	276:297	advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate)	276:414	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	0	46	theme	water	52:56	arg1	Cd2+					70:73	Cd2+	70:73	Cd2+	70:73	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	0	46	theme	water	52:56	arg1	dye					85:87	safranin dye	76:87	safranin dye	76:87	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	0	46	theme	water	52:56	arg1	pollutants					58:67	water pollutants	52:67	water pollutants (Cd2+, safranin dye, and phosphate)	52:103	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	0	46	theme	water	52:56	arg1	phosphate					94:102	phosphate	94:102	phosphate	94:102	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	6	47	theme	EXB/CF	1286:1291	arg1	composite					1293:1301	The EXB/CF composite	1282:1301	The EXB/CF composite	1282:1301	The EXB/CF composite also is of significant recyclability value and applied in five decontamination reusing runs for Cd2+, safranin dye, and phosphate achieving promising removal percentages.
32741761	4	48	theme	calculated	1074:1083	arg1	energies					1090:1097	the calculated free energies	1070:1097	the calculated free energies	1070:1097	The operation of physisorption mechanisms was supported by the obtained adsorption energies from D-R model that are less than 8 kJ/mol as well as the calculated free energies and enthalpies.
32741761	2	49	theme	promising	440:448	arg1	capacities					461:470	The composite achieved promising adsorption capacities	417:470	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).	417:666	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	1	50	theme	enhanced	302:309	arg1	properties					327:336	enhanced decontamination properties	302:336	enhanced decontamination properties	302:336	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	0	51	theme	novel	113:117	arg1	structure					119:127	a novel structure	111:127	a novel structure of exfoliated bentonite admixed with cellulose nanofiber	111:184	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	6	52	theme	removal	1453:1459	arg1	percentages					1461:1471	promising removal percentages	1443:1471	promising removal percentages	1443:1471	The EXB/CF composite also is of significant recyclability value and applied in five decontamination reusing runs for Cd2+, safranin dye, and phosphate achieving promising removal percentages.
32741761	3	53	theme	physisorption	904:916	arg1	type					918:921	physisorption type	904:921	physisorption type	904:921	The adsorption systems for the three species follow the Freundlich isotherm model and Pseudo-First order as kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type.
32741761	5	54	theme	favorable	1244:1252	arg1	reactions					1271:1279	exothermic, favorable, and spontaneous reactions	1232:1279	exothermic, favorable, and spontaneous reactions	1232:1279	The thermodynamic investigation revealed the nature of the adsorption reactions of the three pollutants by EXB/CF as exothermic, favorable, and spontaneous reactions.
32741761	5	54	theme	favorable	1244:1252	arg1	nature					1160:1165	the nature	1156:1165	the nature of the adsorption reactions of the three pollutants	1156:1217	The thermodynamic investigation revealed the nature of the adsorption reactions of the three pollutants by EXB/CF as exothermic, favorable, and spontaneous reactions.
32741761	1	55	theme	decontamination	311:325	arg1	properties					327:336	enhanced decontamination properties	302:336	enhanced decontamination properties	302:336	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	0	56	theme	exfoliated	132:141	arg1	bentonite					143:151	exfoliated bentonite	132:151	exfoliated bentonite admixed with cellulose nanofiber	132:184	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	5	57	theme	reactions	1185:1193	arg1	reactions					1271:1279	exothermic, favorable, and spontaneous reactions	1232:1279	exothermic, favorable, and spontaneous reactions	1232:1279	The thermodynamic investigation revealed the nature of the adsorption reactions of the three pollutants by EXB/CF as exothermic, favorable, and spontaneous reactions.
32741761	5	57	theme	reactions	1185:1193	arg1	nature					1160:1165	the nature	1156:1165	the nature of the adsorption reactions of the three pollutants	1156:1217	The thermodynamic investigation revealed the nature of the adsorption reactions of the three pollutants by EXB/CF as exothermic, favorable, and spontaneous reactions.
32741761	3	58	theme	type	918:921	arg1	properties					890:899	heterogeneous and multilayer uptake properties	854:899	heterogeneous and multilayer uptake properties of physisorption type	854:921	The adsorption systems for the three species follow the Freundlich isotherm model and Pseudo-First order as kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type.
32741761	3	59	theme	isotherm	735:742	arg1	model					744:748	the Freundlich isotherm model	720:748	the Freundlich isotherm model	720:748	The adsorption systems for the three species follow the Freundlich isotherm model and Pseudo-First order as kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type.
32741761	4	60	theme	D-R	1021:1023	arg1	model					1025:1029	D-R model	1021:1029	D-R model that are less than 8 kJ/mol as well as the calculated free energies and enthalpies	1021:1112	The operation of physisorption mechanisms was supported by the obtained adsorption energies from D-R model that are less than 8 kJ/mol as well as the calculated free energies and enthalpies.
32741761	3	61	dep	fitting	832:838	arg1	both					802:805	both	802:805	both	802:805	The adsorption systems for the three species follow the Freundlich isotherm model and Pseudo-First order as kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type.
32741761	3	62	theme	kinetic	776:782	arg1	model					784:788	kinetic model	776:788	kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type	776:921	The adsorption systems for the three species follow the Freundlich isotherm model and Pseudo-First order as kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type.
32741761	2	63	theme	206.8 mg/g	500:509	arg1	capacities					588:597	predicted maximum capacities	570:597	predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate)	570:665	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	2	63	theme	206.8 mg/g	500:509	arg1	values					490:495	experimental values	477:495	experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate)	477:563	The composite achieved promising adsorption capacities with experimental values of 206.8 mg/g (Cd2+), 336 mg/g (safranin), and 296 mg/g (phosphate); and predicted maximum capacities of 212.9 mg/g (Cd2+), 341 mg/g (safranin), and 305 mg/g (phosphate).
32741761	5	64	theme	spontaneous	1259:1269	arg1	reactions					1271:1279	exothermic, favorable, and spontaneous reactions	1232:1279	exothermic, favorable, and spontaneous reactions	1232:1279	The thermodynamic investigation revealed the nature of the adsorption reactions of the three pollutants by EXB/CF as exothermic, favorable, and spontaneous reactions.
32741761	5	64	theme	spontaneous	1259:1269	arg1	nature					1160:1165	the nature	1156:1165	the nature of the adsorption reactions of the three pollutants	1156:1217	The thermodynamic investigation revealed the nature of the adsorption reactions of the three pollutants by EXB/CF as exothermic, favorable, and spontaneous reactions.
32741761	5	65	theme	pollutants	1208:1217	arg1	reactions					1185:1193	the adsorption reactions	1170:1193	the adsorption reactions of the three pollutants	1170:1217	The thermodynamic investigation revealed the nature of the adsorption reactions of the three pollutants by EXB/CF as exothermic, favorable, and spontaneous reactions.
32741761	0	66	theme	pollutants	58:67	arg1	types					43:47	different types	33:47	different types of water pollutants (Cd2+, safranin dye, and phosphate)	33:103	Promoting the decontamination of different types of water pollutants (Cd2+, safranin dye, and phosphate) using a novel structure of exfoliated bentonite admixed with cellulose nanofiber.
32741761	1	67	theme	properties	327:336	arg1	sheets					208:213	Exfoliated bentonite sheets	187:213	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF)	187:257	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	67	theme	properties	327:336	arg1	properties					327:336	enhanced decontamination properties	302:336	enhanced decontamination properties	302:336	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	67	theme	properties	327:336	arg1	bio-composite					285:297	advanced bio-composite	276:297	advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate)	276:414	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	3	68	theme	Freundlich	724:733	arg1	model					744:748	the Freundlich isotherm model	720:748	the Freundlich isotherm model	720:748	The adsorption systems for the three species follow the Freundlich isotherm model and Pseudo-First order as kinetic model considering both the linear and nonlinear fitting demonstrating heterogeneous and multilayer uptake properties of physisorption type.
32741761	4	69	theme	adsorption	996:1005	arg1	energies					1007:1014	the obtained adsorption energies	983:1014	the obtained adsorption energies from D-R model that are less than 8 kJ/mol as well as the calculated free energies and enthalpies	983:1112	The operation of physisorption mechanisms was supported by the obtained adsorption energies from D-R model that are less than 8 kJ/mol as well as the calculated free energies and enthalpies.
32741761	6	70	theme	promising	1443:1451	arg1	percentages					1461:1471	promising removal percentages	1443:1471	promising removal percentages	1443:1471	The EXB/CF composite also is of significant recyclability value and applied in five decontamination reusing runs for Cd2+, safranin dye, and phosphate achieving promising removal percentages.
32741761	1	71	theme	nano-cellulose	228:241	arg1	EXB/CF					251:256	EXB/CF	251:256	EXB/CF	251:256	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
32741761	1	71	theme	nano-cellulose	228:241	arg1	fibers					243:248	nano-cellulose fibers	228:248	nano-cellulose fibers (EXB/CF)	228:257	Exfoliated bentonite sheets admixed with nano-cellulose fibers (EXB/CF) were prepared as advanced bio-composite of enhanced decontamination properties for different species of water pollutants (Cd2+, safranin dye, and phosphate).
35014503	3	0	dep	gelatin	521:527	arg1	to					518:519	to	518:519	to	518:519	Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin) were introduced to make composite hydrogels (G-OKGs).
35014503	5	1	dep	deformation	895:905	arg1	%					916:916	up to 85%	908:916	up to 85% of the original height	908:939	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	5	1	dep	deformation	895:905	arg1	height					934:939	the original height	921:939	the original height	921:939	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	1	2	theme	remarkable	173:182	arg1	properties					196:205	remarkable compressive properties	173:205	remarkable compressive properties	173:205	In this study, gelatin hydrogels with remarkable compressive properties and recoverability were prepared via Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG).
35014503	0	3	theme	Engineering	109:119	arg1	Applications					121:132	Tissue Engineering Applications	102:132	Tissue Engineering Applications	102:132	Gelatin/Oxidized Konjac Glucomannan Composite Hydrogels with High Resistance to Large Deformation for Tissue Engineering Applications.
35014503	6	4	theme	endothelial	1066:1076	arg1	cells					1078:1082	human umbilical vein endothelial cells	1045:1082	human umbilical vein endothelial cells	1045:1082	Additionally, G-OKGs with uniform porous structures are biocompatible to support the proliferation of human umbilical vein endothelial cells.
35014503	0	5	theme	Tissue	102:107	arg1	Applications					121:132	Tissue Engineering Applications	102:132	Tissue Engineering Applications	102:132	Gelatin/Oxidized Konjac Glucomannan Composite Hydrogels with High Resistance to Large Deformation for Tissue Engineering Applications.
35014503	1	6	with	hydrogels	158:166	arg1	recoverability					211:224	recoverability	211:224	recoverability	211:224	In this study, gelatin hydrogels with remarkable compressive properties and recoverability were prepared via Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG).
35014503	1	6	with	hydrogels	158:166	arg1	properties					196:205	remarkable compressive properties	173:205	remarkable compressive properties	173:205	In this study, gelatin hydrogels with remarkable compressive properties and recoverability were prepared via Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG).
35014503	3	7	theme	wt	513:514	arg1	gelatin					521:527	1, 2, 3, 4, and 5 wt % to gelatin	495:527	1, 2, 3, 4, and 5 wt % to gelatin	495:527	Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin) were introduced to make composite hydrogels (G-OKGs).
35014503	3	7	theme	wt	513:514	arg1	OKG					490:492	obtained OKG	481:492	obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin)	481:528	Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin) were introduced to make composite hydrogels (G-OKGs).
35014503	1	8	theme	oxidized	300:307	arg1	OKG					329:331	OKG	329:331	OKG	329:331	In this study, gelatin hydrogels with remarkable compressive properties and recoverability were prepared via Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG).
35014503	1	8	theme	oxidized	300:307	arg1	glucomannan					316:326	oxidized konjac glucomannan	300:326	oxidized konjac glucomannan (OKG)	300:332	In this study, gelatin hydrogels with remarkable compressive properties and recoverability were prepared via Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG).
35014503	5	9	theme	gelatin	765:771	arg1	hydrogels					773:781	pure gelatin hydrogels	760:781	pure gelatin hydrogels	760:781	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	5	10	theme	favorable	851:859	arg1	recoverability					861:874	favorable recoverability	851:874	favorable recoverability	851:874	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	1	11	theme	compressive	184:194	arg1	properties					196:205	remarkable compressive properties	173:205	remarkable compressive properties	173:205	In this study, gelatin hydrogels with remarkable compressive properties and recoverability were prepared via Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG).
35014503	6	12	theme	human	1045:1049	arg1	cells					1078:1082	human umbilical vein endothelial cells	1045:1082	human umbilical vein endothelial cells	1045:1082	Additionally, G-OKGs with uniform porous structures are biocompatible to support the proliferation of human umbilical vein endothelial cells.
35014503	4	13	theme	swelling	703:710	arg1	ratio					712:716	swelling ratio	703:716	swelling ratio	703:716	These G-OKGs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, swelling ratio, and mechanical tests.
35014503	3	14	theme	Various	458:464	arg1	percentages					466:476	Various percentages	458:476	Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin)	458:528	Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin) were introduced to make composite hydrogels (G-OKGs).
35014503	7	15	theme	stable	1160:1165	arg1	hydrogels					1183:1191	mechanically stable and recoverable hydrogels	1147:1191	mechanically stable and recoverable hydrogels	1147:1191	In conclusion, this study provides a reference for developing mechanically stable and recoverable hydrogels, and these kinds of hydrogels show potential capacity in tissue engineering and biomedical applications that may be undergoing extra forces and large deformation.
35014503	5	16	with	comparison	744:753	arg1	hydrogels					773:781	pure gelatin hydrogels	760:781	pure gelatin hydrogels	760:781	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	4	17	theme	scanning	619:626	arg1	SEM					649:651	SEM	649:651	SEM	649:651	These G-OKGs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, swelling ratio, and mechanical tests.
35014503	4	17	theme	scanning	619:626	arg1	microscopy					637:646	scanning electron microscopy	619:646	scanning electron microscopy (SEM)	619:652	These G-OKGs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, swelling ratio, and mechanical tests.
35014503	1	18	theme	konjac	309:314	arg1	OKG					329:331	OKG	329:331	OKG	329:331	In this study, gelatin hydrogels with remarkable compressive properties and recoverability were prepared via Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG).
35014503	1	18	theme	konjac	309:314	arg1	glucomannan					316:326	oxidized konjac glucomannan	300:326	oxidized konjac glucomannan (OKG)	300:332	In this study, gelatin hydrogels with remarkable compressive properties and recoverability were prepared via Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG).
35014503	4	19	theme	infrared	673:680	arg1	spectroscopy					689:700	infrared (FTIR) spectroscopy	673:700	infrared (FTIR) spectroscopy	673:700	These G-OKGs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, swelling ratio, and mechanical tests.
35014503	6	20	theme	porous	977:982	arg1	structures					984:993	uniform porous structures	969:993	uniform porous structures	969:993	Additionally, G-OKGs with uniform porous structures are biocompatible to support the proliferation of human umbilical vein endothelial cells.
35014503	7	21	theme	extra	1320:1324	arg1	forces					1326:1331	extra forces	1320:1331	extra forces	1320:1331	In conclusion, this study provides a reference for developing mechanically stable and recoverable hydrogels, and these kinds of hydrogels show potential capacity in tissue engineering and biomedical applications that may be undergoing extra forces and large deformation.
35014503	3	22	theme	%	516:516	arg1	gelatin					521:527	1, 2, 3, 4, and 5 wt % to gelatin	495:527	1, 2, 3, 4, and 5 wt % to gelatin	495:527	Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin) were introduced to make composite hydrogels (G-OKGs).
35014503	3	22	theme	%	516:516	arg1	OKG					490:492	obtained OKG	481:492	obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin)	481:528	Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin) were introduced to make composite hydrogels (G-OKGs).
35014503	5	23	dep	exhibit	795:801	arg1	increased					817:825	increased	817:825	exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height)	795:940	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	3	24	theme	obtained	481:488	arg1	gelatin					521:527	1, 2, 3, 4, and 5 wt % to gelatin	495:527	1, 2, 3, 4, and 5 wt % to gelatin	495:527	Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin) were introduced to make composite hydrogels (G-OKGs).
35014503	3	24	theme	obtained	481:488	arg1	OKG					490:492	obtained OKG	481:492	obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin)	481:528	Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin) were introduced to make composite hydrogels (G-OKGs).
35014503	4	25	dep	Fourier	655:661	arg1	transform					663:671	transform	663:671	transform infrared (FTIR) spectroscopy	663:700	These G-OKGs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, swelling ratio, and mechanical tests.
35014503	5	26	theme	cyclic	882:887	arg1	deformation					895:905	cyclic large deformation	882:905	cyclic large deformation (up to 85% of the original height)	882:940	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	5	27	dep	stress	827:832	arg1	deformation					895:905	cyclic large deformation	882:905	cyclic large deformation (up to 85% of the original height)	882:940	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	3	28	theme	OKG	490:492	arg1	percentages					466:476	Various percentages	458:476	Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin)	458:528	Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin) were introduced to make composite hydrogels (G-OKGs).
35014503	6	29	theme	umbilical	1051:1059	arg1	cells					1078:1082	human umbilical vein endothelial cells	1045:1082	human umbilical vein endothelial cells	1045:1082	Additionally, G-OKGs with uniform porous structures are biocompatible to support the proliferation of human umbilical vein endothelial cells.
35014503	5	30	theme	height	934:939	arg1	%					916:916	up to 85%	908:916	up to 85% of the original height	908:939	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	5	30	theme	height	934:939	arg1	height					934:939	the original height	921:939	the original height	921:939	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	7	31	theme	large	1337:1341	arg1	deformation					1343:1353	large deformation	1337:1353	large deformation	1337:1353	In conclusion, this study provides a reference for developing mechanically stable and recoverable hydrogels, and these kinds of hydrogels show potential capacity in tissue engineering and biomedical applications that may be undergoing extra forces and large deformation.
35014503	2	32	theme	oxidation	408:416	arg1	temperature					418:428	oxidation temperature	408:428	oxidation temperature	408:428	The process of OKG was first optimized by adjusting parameters, that is, oxidation temperature and time during processing.
35014503	6	33	theme	vein	1061:1064	arg1	cells					1078:1082	human umbilical vein endothelial cells	1045:1082	human umbilical vein endothelial cells	1045:1082	Additionally, G-OKGs with uniform porous structures are biocompatible to support the proliferation of human umbilical vein endothelial cells.
35014503	0	34	theme	High	61:64	arg1	Resistance					66:75	High Resistance	61:75	High Resistance to Large Deformation	61:96	Gelatin/Oxidized Konjac Glucomannan Composite Hydrogels with High Resistance to Large Deformation for Tissue Engineering Applications.
35014503	6	35	with	G-OKGs	957:962	arg1	structures					984:993	uniform porous structures	969:993	uniform porous structures	969:993	Additionally, G-OKGs with uniform porous structures are biocompatible to support the proliferation of human umbilical vein endothelial cells.
35014503	6	36	theme	cells	1078:1082	arg1	proliferation					1028:1040	the proliferation	1024:1040	the proliferation of human umbilical vein endothelial cells	1024:1082	Additionally, G-OKGs with uniform porous structures are biocompatible to support the proliferation of human umbilical vein endothelial cells.
35014503	7	37	from	capacity	1238:1245	arg1	engineering					1257:1267	tissue engineering	1250:1267	tissue engineering	1250:1267	In conclusion, this study provides a reference for developing mechanically stable and recoverable hydrogels, and these kinds of hydrogels show potential capacity in tissue engineering and biomedical applications that may be undergoing extra forces and large deformation.
35014503	7	37	from	capacity	1238:1245	arg1	applications					1284:1295	biomedical applications	1273:1295	biomedical applications	1273:1295	In conclusion, this study provides a reference for developing mechanically stable and recoverable hydrogels, and these kinds of hydrogels show potential capacity in tissue engineering and biomedical applications that may be undergoing extra forces and large deformation.
35014503	5	38	dep	85	914:915	arg1	to					911:912	to	911:912	to	911:912	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	5	39	theme	original	925:932	arg1	height					934:939	the original height	921:939	the original height	921:939	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	2	40	theme	OKG	350:352	arg1	process					339:345	The process	335:345	The process of OKG	335:352	The process of OKG was first optimized by adjusting parameters, that is, oxidation temperature and time during processing.
35014503	5	41	theme	large	889:893	arg1	deformation					895:905	cyclic large deformation	882:905	cyclic large deformation (up to 85% of the original height)	882:940	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	7	42	theme	hydrogels	1213:1221	arg1	kinds					1204:1208	these kinds	1198:1208	these kinds of hydrogels	1198:1221	In conclusion, this study provides a reference for developing mechanically stable and recoverable hydrogels, and these kinds of hydrogels show potential capacity in tissue engineering and biomedical applications that may be undergoing extra forces and large deformation.
35014503	6	43	theme	uniform	969:975	arg1	structures					984:993	uniform porous structures	969:993	uniform porous structures	969:993	Additionally, G-OKGs with uniform porous structures are biocompatible to support the proliferation of human umbilical vein endothelial cells.
35014503	4	44	dep	infrared	673:680	arg1	FTIR					683:686	FTIR	683:686	FTIR	683:686	These G-OKGs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, swelling ratio, and mechanical tests.
35014503	7	45	theme	tissue	1250:1255	arg1	engineering					1257:1267	tissue engineering	1250:1267	tissue engineering	1250:1267	In conclusion, this study provides a reference for developing mechanically stable and recoverable hydrogels, and these kinds of hydrogels show potential capacity in tissue engineering and biomedical applications that may be undergoing extra forces and large deformation.
35014503	1	46	theme	base	252:255	arg1	cross-linking					266:278	Shiff's base chemical cross-linking	244:278	Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG)	244:332	In this study, gelatin hydrogels with remarkable compressive properties and recoverability were prepared via Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG).
35014503	0	47	theme	Large	80:84	arg1	Deformation					86:96	Large Deformation	80:96	Large Deformation	80:96	Gelatin/Oxidized Konjac Glucomannan Composite Hydrogels with High Resistance to Large Deformation for Tissue Engineering Applications.
35014503	7	48	theme	potential	1228:1236	arg1	capacity					1238:1245	potential capacity	1228:1245	potential capacity in tissue engineering and biomedical applications that may be undergoing extra forces and large deformation	1228:1353	In conclusion, this study provides a reference for developing mechanically stable and recoverable hydrogels, and these kinds of hydrogels show potential capacity in tissue engineering and biomedical applications that may be undergoing extra forces and large deformation.
35014503	3	49	theme	composite	554:562	arg1	hydrogels					564:572	composite hydrogels	554:572	composite hydrogels (G-OKGs)	554:581	Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin) were introduced to make composite hydrogels (G-OKGs).
35014503	3	49	theme	composite	554:562	arg1	G-OKGs					575:580	G-OKGs	575:580	G-OKGs	575:580	Various percentages of obtained OKG (1, 2, 3, 4, and 5 wt % to gelatin) were introduced to make composite hydrogels (G-OKGs).
35014503	5	50	theme	pure	760:763	arg1	hydrogels					773:781	pure gelatin hydrogels	760:781	pure gelatin hydrogels	760:781	In comparison with pure gelatin hydrogels, the G-OKGs exhibit significantly increased stress and modulus, and favorable recoverability after cyclic large deformation (up to 85% of the original height).
35014503	1	51	theme	gelatin	150:156	arg1	hydrogels					158:166	gelatin hydrogels	150:166	gelatin hydrogels with remarkable compressive properties and recoverability	150:224	In this study, gelatin hydrogels with remarkable compressive properties and recoverability were prepared via Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG).
35014503	7	52	theme	biomedical	1273:1282	arg1	applications					1284:1295	biomedical applications	1273:1295	biomedical applications	1273:1295	In conclusion, this study provides a reference for developing mechanically stable and recoverable hydrogels, and these kinds of hydrogels show potential capacity in tissue engineering and biomedical applications that may be undergoing extra forces and large deformation.
35014503	1	53	theme	chemical	257:264	arg1	cross-linking					266:278	Shiff's base chemical cross-linking	244:278	Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG)	244:332	In this study, gelatin hydrogels with remarkable compressive properties and recoverability were prepared via Shiff's base chemical cross-linking between gelatin and oxidized konjac glucomannan (OKG).
35014503	4	54	theme	mechanical	723:732	arg1	tests					734:738	mechanical tests	723:738	mechanical tests	723:738	These G-OKGs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, swelling ratio, and mechanical tests.
35014503	4	55	theme	electron	628:635	arg1	SEM					649:651	SEM	649:651	SEM	649:651	These G-OKGs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, swelling ratio, and mechanical tests.
35014503	4	55	theme	electron	628:635	arg1	microscopy					637:646	scanning electron microscopy	619:646	scanning electron microscopy (SEM)	619:652	These G-OKGs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, swelling ratio, and mechanical tests.
35014503	7	56	theme	recoverable	1171:1181	arg1	hydrogels					1183:1191	mechanically stable and recoverable hydrogels	1147:1191	mechanically stable and recoverable hydrogels	1147:1191	In conclusion, this study provides a reference for developing mechanically stable and recoverable hydrogels, and these kinds of hydrogels show potential capacity in tissue engineering and biomedical applications that may be undergoing extra forces and large deformation.
33497185	1	0	theme	slow	178:181	arg1	absorption					183:192	slow absorption	178:192	slow absorption	178:192	Conventional absorbents for hemoperfusions suffer from low efficiency and slow absorption with numerous side effects.
33497185	5	1	theme	μmol	1055:1058	arg1	L-1					1060:1062	93.4 to 54.14 μmol L-1	1041:1062	93.4 to 54.14 μmol L-1	1041:1062	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	5	2	dep	Sprague-Dawley	903:916	arg1	n					919:919	n = 30	919:924	n = 30	919:924	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	0	3	theme	Direct	82:87	arg1	Hemoperfusion					89:101	Direct Hemoperfusion	82:101	Direct Hemoperfusion	82:101	Elimination of Uremic Toxins by Functionalized Graphene-Based Composite Beads for Direct Hemoperfusion.
33497185	7	4	theme	disease	1573:1579	arg1	treatment					1546:1554	the treatment	1542:1554	the treatment of blood-related disease	1542:1579	These results provide critical insight to fabricate graphene-based beads for hemoperfusion and to have the potential for the treatment of blood-related disease.
33497185	4	5	theme	p	777:777	arg1	<					779:779	p < 0.005	777:785	p < 0.005	777:785	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	4	5	theme	p	777:777	arg1	acid					750:753	uric acid	745:753	uric acid from 0.31 to 0.15 mM (p < 0.005)	745:786	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	2	6	dep	oxide	300:304	arg1	GO					307:308	GO	307:308	GO	307:308	In this research, we developed cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction.
33497185	6	7	theme	CA	1228:1229	arg1	presence					1216:1223	the presence	1212:1223	the presence of CA on GO	1212:1235	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	6	8	theme	molecular	1133:1141	arg1	MD					1153:1154	MD	1153:1154	MD	1153:1154	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	6	8	theme	molecular	1133:1141	arg1	dynamics					1143:1150	molecular dynamics	1133:1150	molecular dynamics (MD) simulations using free-energy calculations	1133:1198	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	6	9	theme	der	1385:1387	arg1	interactions					1407:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	6	10	theme	vdW	1402:1404	arg1	interactions					1407:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	5	11	from	L-1	1060:1062	arg1	p					1065:1065	p < 0.0001	1065:1074	p < 0.0001	1065:1074	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	5	11	from	L-1	1060:1062	arg1	p					1010:1010	p < 0.0001	1010:1019	p < 0.0001	1010:1019	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	5	11	from	L-1	1060:1062	arg1	acid					1031:1034	uric acid	1026:1034	uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001)	1026:1075	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	5	11	from	L-1	1060:1062	arg1	L-1					1005:1007	from 83.23 to 54.87 μmol L-1	980:1007	from 83.23 to 54.87 μmol L-1 (p < 0.0001)	980:1020	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	7	12	theme	graphene-based	1473:1486	arg1	beads					1488:1492	graphene-based beads	1473:1492	graphene-based beads for hemoperfusion	1473:1510	These results provide critical insight to fabricate graphene-based beads for hemoperfusion and to have the potential for the treatment of blood-related disease.
33497185	5	13	dep	54.87	994:998	arg1	to					991:992	to	991:992	to	991:992	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	4	14	theme	p	733:733	arg1	μM					729:730	from 0.21 to 0.12 μM	711:730	from 0.21 to 0.12 μM (p < 0.005)	711:742	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	4	14	theme	p	733:733	arg1	<					735:735	p < 0.005	733:741	p < 0.005	733:741	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	2	15	used	used	341:344	arg2	beads					311:315	graphene oxide (GO) beads	291:315	cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction	253:416	In this research, we developed cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction.
33497185	2	15	used	used	341:344	arg2	mm					325:326	∼1.5-2 mm	318:326	∼1.5-2 mm	318:326	In this research, we developed cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction.
33497185	2	16	theme	oxide	300:304	arg1	beads					311:315	graphene oxide (GO) beads	291:315	cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction	253:416	In this research, we developed cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction.
33497185	2	16	theme	oxide	300:304	arg1	mm					325:326	∼1.5-2 mm	318:326	∼1.5-2 mm	318:326	In this research, we developed cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction.
33497185	5	17	theme	uric	1026:1029	arg1	p					1065:1065	p < 0.0001	1065:1074	p < 0.0001	1065:1074	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	5	17	theme	uric	1026:1029	arg1	acid					1031:1034	uric acid	1026:1034	uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001)	1026:1075	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	3	18	with	adsorption	461:470	arg1	biocompatibility					492:507	high biocompatibility	487:507	high biocompatibility	487:507	The CA-functionalized GO bead facilitates adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion while maintaining high retention for red blood cell, white blood cells, and platelets.
33497185	3	18	with	adsorption	461:470	arg1	high-efficiency					513:527	high-efficiency	513:527	high-efficiency of hemoperfusion	513:544	The CA-functionalized GO bead facilitates adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion while maintaining high retention for red blood cell, white blood cells, and platelets.
33497185	6	19	theme	force	1395:1399	arg1	interactions					1407:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	2	20	theme	graphene	291:298	arg1	oxide					300:304	graphene oxide	291:304	cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction	253:416	In this research, we developed cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction.
33497185	5	21	dep	in	880:881	arg1	vivo					883:886	vivo	883:886	vivo	883:886	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	6	22	theme	Waals	1389:1393	arg1	interactions					1407:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	2	23	theme	functionalized	276:289	arg1	beads					311:315	graphene oxide (GO) beads	291:315	cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction	253:416	In this research, we developed cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction.
33497185	2	23	theme	functionalized	276:289	arg1	mm					325:326	∼1.5-2 mm	318:326	∼1.5-2 mm	318:326	In this research, we developed cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction.
33497185	1	24	theme	numerous	199:206	arg1	effects					213:219	numerous side effects	199:219	numerous side effects	199:219	Conventional absorbents for hemoperfusions suffer from low efficiency and slow absorption with numerous side effects.
33497185	6	25	theme	dynamics	1143:1150	arg1	simulations					1157:1167	molecular dynamics (MD) simulations	1133:1167	molecular dynamics (MD) simulations using free-energy calculations	1133:1198	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	7	26	theme	blood-related	1559:1571	arg1	disease					1573:1579	blood-related disease	1559:1579	blood-related disease	1559:1579	These results provide critical insight to fabricate graphene-based beads for hemoperfusion and to have the potential for the treatment of blood-related disease.
33497185	4	27	dep	0.09	816:819	arg1	to					813:814	to	813:814	to	813:814	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	7	28	theme	critical	1443:1450	arg1	insight					1452:1458	critical insight	1443:1458	critical insight to fabricate graphene-based beads for hemoperfusion and to have the potential for the treatment of blood-related disease	1443:1579	These results provide critical insight to fabricate graphene-based beads for hemoperfusion and to have the potential for the treatment of blood-related disease.
33497185	1	29	theme	side	208:211	arg1	effects					213:219	numerous side effects	199:219	numerous side effects	199:219	Conventional absorbents for hemoperfusions suffer from low efficiency and slow absorption with numerous side effects.
33497185	5	30	dep	54.14	1049:1053	arg1	to					1046:1047	to	1046:1047	to	1046:1047	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	1	31	theme	Conventional	104:115	arg1	absorbents					117:126	Conventional absorbents	104:126	Conventional absorbents for hemoperfusions	104:145	Conventional absorbents for hemoperfusions suffer from low efficiency and slow absorption with numerous side effects.
33497185	5	32	from	study	888:892	arg1	Sprague-Dawley					903:916	Sprague-Dawley	903:916	Sprague-Dawley	903:916	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	5	32	from	study	888:892	arg1	rats					897:900	rats	897:900	rats (Sprague-Dawley, n = 30)	897:925	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	2	33	theme	direct	350:355	arg1	hemoperfusion					357:369	direct hemoperfusion	350:369	direct hemoperfusion	350:369	In this research, we developed cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction.
33497185	0	34	theme	Toxins	22:27	arg1	Elimination					0:10	Elimination	0:10	Elimination of Uremic Toxins by Functionalized Graphene-Based Composite Beads for Direct Hemoperfusion.	0:102	Elimination of Uremic Toxins by Functionalized Graphene-Based Composite Beads for Direct Hemoperfusion.
33497185	6	35	theme	van	1381:1383	arg1	interactions					1407:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	6	36	from	penetration	1292:1302	arg1	cavities					1329:1336	the binding cavities	1317:1336	the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions	1317:1418	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	3	37	theme	high	564:567	arg1	retention					569:577	high retention	564:577	high retention for red blood cell, white blood cells, and platelets	564:630	The CA-functionalized GO bead facilitates adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion while maintaining high retention for red blood cell, white blood cells, and platelets.
33497185	5	38	theme	in	880:881	arg1	study					888:892	Our in vivo study	876:892	Our in vivo study on rats (Sprague-Dawley, n = 30)	876:925	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	2	39	theme	kidney	399:404	arg1	dysfunction					406:416	kidney dysfunction	399:416	kidney dysfunction	399:416	In this research, we developed cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction.
33497185	7	40	dep	insight	1452:1458	arg1	fabricate					1463:1471	fabricate	1463:1471	to fabricate graphene-based beads for hemoperfusion	1460:1510	These results provide critical insight to fabricate graphene-based beads for hemoperfusion and to have the potential for the treatment of blood-related disease.
33497185	7	40	dep	insight	1452:1458	arg1	have					1519:1522	have	1519:1522	to have the potential for the treatment of blood-related disease	1516:1579	These results provide critical insight to fabricate graphene-based beads for hemoperfusion and to have the potential for the treatment of blood-related disease.
33497185	6	41	from	cavities	1329:1336	arg1	penetration					1292:1302	penetration	1292:1302	penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions	1292:1418	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	4	42	dep	0.15	768:771	arg1	to					765:766	to	765:766	to	765:766	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	0	43	theme	Functionalized	32:45	arg1	Beads					72:76	Functionalized Graphene-Based Composite Beads	32:76	Functionalized Graphene-Based Composite Beads for Direct Hemoperfusion	32:101	Elimination of Uremic Toxins by Functionalized Graphene-Based Composite Beads for Direct Hemoperfusion.
33497185	5	44	theme	<	1012:1012	arg1	p					1010:1010	p < 0.0001	1010:1019	p < 0.0001	1010:1019	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	5	44	theme	<	1012:1012	arg1	L-1					1005:1007	from 83.23 to 54.87 μmol L-1	980:1007	from 83.23 to 54.87 μmol L-1 (p < 0.0001)	980:1020	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	4	45	theme	in	637:638	arg1	results					646:652	Our in vitro results	633:652	Our in vitro results	633:652	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	4	46	dep	in	637:638	arg1	vitro					640:644	vitro	640:644	vitro	640:644	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	5	47	theme	normal	1091:1096	arg1	levels					1098:1103	normal levels	1091:1103	normal levels within 30 min	1091:1117	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	3	48	theme	CA-functionalized	423:439	arg1	bead					444:447	The CA-functionalized GO bead	419:447	The CA-functionalized GO bead	419:447	The CA-functionalized GO bead facilitates adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion while maintaining high retention for red blood cell, white blood cells, and platelets.
33497185	6	49	theme	free-energy	1175:1185	arg1	calculations					1187:1198	free-energy calculations	1175:1198	free-energy calculations	1175:1198	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	4	50	theme	p	825:825	arg1	mM					821:822	0.36 to 0.09 mM	808:822	0.36 to 0.09 mM (p < 0.005)	808:834	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	4	50	theme	p	825:825	arg1	<					827:827	p < 0.005	825:833	p < 0.005	825:833	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	6	51	from	presence	1216:1223	arg1	GO					1234:1235	GO	1234:1235	GO	1234:1235	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	2	52	theme	dysfunction	406:416	arg1	treatment					386:394	the treatment	382:394	the treatment of kidney dysfunction	382:416	In this research, we developed cellulose acetate (CA) functionalized graphene oxide (GO) beads (∼1.5-2 mm) that can be used for direct hemoperfusion, aiming at the treatment of kidney dysfunction.
33497185	4	53	from	mM	773:774	arg1	μM					729:730	from 0.21 to 0.12 μM	711:730	from 0.21 to 0.12 μM (p < 0.005)	711:742	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	4	53	from	mM	773:774	arg1	acid					750:753	uric acid	745:753	uric acid from 0.31 to 0.15 mM (p < 0.005)	745:786	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	4	53	from	mM	773:774	arg1	<					779:779	p < 0.005	777:785	p < 0.005	777:785	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	4	53	from	mM	773:774	arg1	<					735:735	p < 0.005	733:741	p < 0.005	733:741	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	4	53	from	mM	773:774	arg1	bilirubin					793:801	bilirubin	793:801	bilirubin	793:801	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	3	54	theme	GO	441:442	arg1	bead					444:447	The CA-functionalized GO bead	419:447	The CA-functionalized GO bead	419:447	The CA-functionalized GO bead facilitates adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion while maintaining high retention for red blood cell, white blood cells, and platelets.
33497185	0	55	theme	Composite	62:70	arg1	Beads					72:76	Functionalized Graphene-Based Composite Beads	32:76	Functionalized Graphene-Based Composite Beads for Direct Hemoperfusion	32:101	Elimination of Uremic Toxins by Functionalized Graphene-Based Composite Beads for Direct Hemoperfusion.
33497185	3	56	theme	high	487:490	arg1	biocompatibility					492:507	high biocompatibility	487:507	high biocompatibility	487:507	The CA-functionalized GO bead facilitates adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion while maintaining high retention for red blood cell, white blood cells, and platelets.
33497185	3	57	theme	blood	587:591	arg1	cell					593:596	red blood cell	583:596	red blood cell	583:596	The CA-functionalized GO bead facilitates adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion while maintaining high retention for red blood cell, white blood cells, and platelets.
33497185	6	58	theme	increased	1353:1361	arg1	interactions					1407:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	3	59	theme	toxins	475:480	arg1	adsorption					461:470	adsorption	461:470	adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion	461:544	The CA-functionalized GO bead facilitates adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion while maintaining high retention for red blood cell, white blood cells, and platelets.
33497185	0	60	theme	Graphene-Based	47:60	arg1	Beads					72:76	Functionalized Graphene-Based Composite Beads	32:76	Functionalized Graphene-Based Composite Beads for Direct Hemoperfusion	32:101	Elimination of Uremic Toxins by Functionalized Graphene-Based Composite Beads for Direct Hemoperfusion.
33497185	6	61	from	toxins	1307:1312	arg1	cavities					1329:1336	the binding cavities	1317:1336	the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions	1317:1418	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	5	62	theme	μmol	1000:1003	arg1	p					1010:1010	p < 0.0001	1010:1019	p < 0.0001	1010:1019	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	5	62	theme	μmol	1000:1003	arg1	L-1					1005:1007	from 83.23 to 54.87 μmol L-1	980:1007	from 83.23 to 54.87 μmol L-1 (p < 0.0001)	980:1020	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	6	63	from	simulations	1157:1167	arg1	Results					1120:1126	Results	1120:1126	Results from molecular dynamics (MD) simulations using free-energy calculations	1120:1198	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	4	64	theme	uric	745:748	arg1	acid					750:753	uric acid	745:753	uric acid from 0.31 to 0.15 mM (p < 0.005)	745:786	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	4	64	theme	uric	745:748	arg1	<					779:779	p < 0.005	777:785	p < 0.005	777:785	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	3	65	theme	white	599:603	arg1	cells					611:615	white blood cells	599:615	white blood cells	599:615	The CA-functionalized GO bead facilitates adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion while maintaining high retention for red blood cell, white blood cells, and platelets.
33497185	4	66	dep	0.12	724:727	arg1	to					721:722	to	721:722	to	721:722	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	5	67	theme	<	1067:1067	arg1	acid					1031:1034	uric acid	1026:1034	uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001)	1026:1075	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	5	67	theme	<	1067:1067	arg1	p					1065:1065	p < 0.0001	1065:1074	p < 0.0001	1065:1074	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	3	68	theme	hemoperfusion	532:544	arg1	biocompatibility					492:507	high biocompatibility	487:507	high biocompatibility	487:507	The CA-functionalized GO bead facilitates adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion while maintaining high retention for red blood cell, white blood cells, and platelets.
33497185	3	68	theme	hemoperfusion	532:544	arg1	high-efficiency					513:527	high-efficiency	513:527	high-efficiency of hemoperfusion	513:544	The CA-functionalized GO bead facilitates adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion while maintaining high retention for red blood cell, white blood cells, and platelets.
33497185	6	69	theme	toxins	1307:1312	arg1	penetration					1292:1302	penetration	1292:1302	penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions	1292:1418	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	6	70	theme	electrostatic	1363:1375	arg1	interactions					1407:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	the increased electrostatic and van der Waals force (vdW) interactions	1349:1418	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	5	71	theme	=	921:921	arg1	n					919:919	n = 30	919:924	n = 30	919:924	Our in vivo study on rats (Sprague-Dawley, n = 30) showed that the concentration for creatinine reduced from 83.23 to 54.87 μmol L-1 (p < 0.0001) and uric acid from 93.4 to 54.14 μmol L-1 (p < 0.0001), restoring to normal levels within 30 min.
33497185	1	72	theme	low	159:161	arg1	efficiency					163:172	low efficiency	159:172	low efficiency	159:172	Conventional absorbents for hemoperfusions suffer from low efficiency and slow absorption with numerous side effects.
33497185	4	73	theme	normal	850:855	arg1	levels					857:862	normal levels	850:862	normal levels	850:862	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	6	74	theme	interactions	1407:1418	arg1	cavities					1329:1336	the binding cavities	1317:1336	the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions	1317:1418	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	3	75	theme	blood	605:609	arg1	cells					611:615	white blood cells	599:615	white blood cells	599:615	The CA-functionalized GO bead facilitates adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion while maintaining high retention for red blood cell, white blood cells, and platelets.
33497185	6	76	attach	presence	1216:1223	arg1	GO					1234:1235	GO	1234:1235	GO	1234:1235	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	6	76	attach	presence	1216:1223	arg2	CA					1228:1229	CA	1228:1229	CA	1228:1229	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	4	77	theme	toxin	668:672	arg1	concentration					674:686	the toxin concentration	664:686	the toxin concentration for creatinine	664:701	Our in vitro results show that the toxin concentration for creatinine reduced from 0.21 to 0.12 μM (p < 0.005), uric acid from 0.31 to 0.15 mM (p < 0.005), and bilirubin from 0.36 to 0.09 mM (p < 0.005), restoring to normal levels within 2 h.
33497185	6	78	theme	surface	1251:1257	arg1	area					1259:1262	the surface area	1247:1262	the surface area for adsorption	1247:1277	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	0	79	theme	Uremic	15:20	arg1	Toxins					22:27	Uremic Toxins	15:27	Uremic Toxins	15:27	Elimination of Uremic Toxins by Functionalized Graphene-Based Composite Beads for Direct Hemoperfusion.
33497185	6	80	theme	binding	1321:1327	arg1	cavities					1329:1336	the binding cavities	1317:1336	the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions	1317:1418	Results from molecular dynamics (MD) simulations using free-energy calculations reveal that the presence of CA on GO increases the surface area for adsorption and enhances penetration of toxins in the binding cavities because of the increased electrostatic and van der Waals force (vdW) interactions.
33497185	3	81	theme	red	583:585	arg1	cell					593:596	red blood cell	583:596	red blood cell	583:596	The CA-functionalized GO bead facilitates adsorption of toxins with high biocompatibility and high-efficiency of hemoperfusion while maintaining high retention for red blood cell, white blood cells, and platelets.
33581680	7	0	theme	system	939:944	arg1	value					949:953	system pH value	939:953	system pH value	939:953	The factors affecting the study include the temperature, adsorption time, amount of adsorbent and system pH value.
33581680	1	1	theme	excellent	149:157	arg1	properties					170:179	excellent adsorption properties	149:179	excellent adsorption properties	149:179	Graphene oxide (GO) and GO-based materials have shown excellent adsorption properties because of bounteous structure and rich oxygen functional groups.
33581680	13	2	from	efficient	1557:1565	arg1	removal					1582:1588	the removal	1578:1588	the removal of organic dyes	1578:1604	In these tests, β-CD/GO was suggested to be more efficient than GO in the removal of organic dyes.
33581680	0	3	theme	blue	89:92	arg1	methylene					79:87	methylene blue	79:92	methylene blue	79:92	Preparation of β-cyclodextrin/graphene oxide and its adsorption properties for methylene blue.
33581680	10	4	theme	70	1366:1367	arg1	%					1368:1368	%	1368:1368	%	1368:1368	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	9	5	theme	adsorption	1133:1142	arg1	factors					1144:1150	the same adsorption factors	1124:1150	the same adsorption factors	1124:1150	The results show that β-CD/GO has a different adsorption capacity from GO under the same adsorption factors.
33581680	1	6	dep	oxide	104:108	arg1	GO					111:112	GO	111:112	GO	111:112	Graphene oxide (GO) and GO-based materials have shown excellent adsorption properties because of bounteous structure and rich oxygen functional groups.
33581680	2	7	used	utilized	283:290	arg2	GO					276:277	GO	276:277	GO	276:277	Many studies have shown that GO are utilized as adsorbents to remove organic dyes from wastewater.
33581680	2	7	used	utilized	283:290	arg2	adsorbents					295:304	adsorbents	295:304	adsorbents	295:304	Many studies have shown that GO are utilized as adsorbents to remove organic dyes from wastewater.
33581680	8	8	theme	adsorption	996:1005	arg1	process					1007:1013	the adsorption process	992:1013	the adsorption process	992:1013	Adsorption isotherm and kinetics of the adsorption process are systematically analyzed.
33581680	7	9	theme	adsorbent	925:933	arg1	amount					915:920	amount	915:920	amount of adsorbent	915:933	The factors affecting the study include the temperature, adsorption time, amount of adsorbent and system pH value.
33581680	7	9	theme	adsorbent	925:933	arg1	temperature					885:895	the temperature	881:895	the temperature	881:895	The factors affecting the study include the temperature, adsorption time, amount of adsorbent and system pH value.
33581680	7	9	theme	adsorbent	925:933	arg1	time					909:912	adsorption time	898:912	adsorption time	898:912	The factors affecting the study include the temperature, adsorption time, amount of adsorbent and system pH value.
33581680	7	9	theme	adsorbent	925:933	arg1	value					949:953	system pH value	939:953	system pH value	939:953	The factors affecting the study include the temperature, adsorption time, amount of adsorbent and system pH value.
33581680	7	9	theme	adsorbent	925:933	arg1	adsorbent					925:933	adsorbent	925:933	adsorbent	925:933	The factors affecting the study include the temperature, adsorption time, amount of adsorbent and system pH value.
33581680	9	10	theme	same	1128:1131	arg1	factors					1144:1150	the same adsorption factors	1124:1150	the same adsorption factors	1124:1150	The results show that β-CD/GO has a different adsorption capacity from GO under the same adsorption factors.
33581680	10	11	theme	optimized	1163:1171	arg1	conditions					1173:1182	the optimized conditions	1159:1182	the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L)	1159:1294	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	2	12	theme	organic	316:322	arg1	dyes					324:327	organic dyes	316:327	organic dyes	316:327	Many studies have shown that GO are utilized as adsorbents to remove organic dyes from wastewater.
33581680	8	13	theme	Adsorption	956:965	arg1	isotherm					967:974	Adsorption isotherm	956:974	Adsorption isotherm	956:974	Adsorption isotherm and kinetics of the adsorption process are systematically analyzed.
33581680	4	14	theme	composite	473:481	arg1	β-CD/GO					484:490	β-CD/GO	484:490	β-CD/GO	484:490	On this basis, β-cyclodextrin/graphene oxide composite (β-CD/GO) was prepared by modifying graphene oxide via β-cyclodextrin(β-CD) crosslinking method.
33581680	4	14	theme	composite	473:481	arg1	oxide					467:471	β-cyclodextrin/graphene oxide composite	443:481	β-cyclodextrin/graphene oxide composite (β-CD/GO)	443:491	On this basis, β-cyclodextrin/graphene oxide composite (β-CD/GO) was prepared by modifying graphene oxide via β-cyclodextrin(β-CD) crosslinking method.
33581680	10	15	theme	β-CD/GO	1323:1329	arg1	efficiency					1309:1318	the removal efficiency	1297:1318	the removal efficiency of β-CD/GO	1297:1329	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	10	15	theme	β-CD/GO	1323:1329	arg1	higher					1338:1343	higher	1338:1343	higher	1338:1343	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	9	16	from	GO	1115:1116	arg1	capacity					1101:1108	a different adsorption capacity	1078:1108	a different adsorption capacity from GO	1078:1116	The results show that β-CD/GO has a different adsorption capacity from GO under the same adsorption factors.
33581680	5	17	dep	transform	622:630	arg1	infrared					632:639	infrared	632:639	transform infrared spectroscopy (FT-IR), energy-dispersive X-ray (XRD), scanning electron (SEM) and thermogravimetric analysis (TGA)	622:753	GO and β-CD were characterized by Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray (XRD), scanning electron (SEM) and thermogravimetric analysis (TGA).
33581680	8	18	theme	process	1007:1013	arg1	kinetics					980:987	kinetics	980:987	kinetics	980:987	Adsorption isotherm and kinetics of the adsorption process are systematically analyzed.
33581680	8	18	theme	process	1007:1013	arg1	isotherm					967:974	Adsorption isotherm	956:974	Adsorption isotherm	956:974	Adsorption isotherm and kinetics of the adsorption process are systematically analyzed.
33581680	6	19	theme	adsorbents	762:771	arg1	properties					773:782	Their adsorbents properties	756:782	Their adsorbents properties	756:782	Their adsorbents properties have been studied with methylene blue (MB) as adsorbate.
33581680	6	19	theme	adsorbents	762:771	arg1	adsorbate					830:838	adsorbate	830:838	adsorbate	830:838	Their adsorbents properties have been studied with methylene blue (MB) as adsorbate.
33581680	10	20	theme	90	1373:1374	arg1	%					1368:1368	%	1368:1368	%	1368:1368	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	1	21	theme	Graphene	95:102	arg1	oxide					104:108	Graphene oxide	95:108	Graphene oxide (GO)	95:113	Graphene oxide (GO) and GO-based materials have shown excellent adsorption properties because of bounteous structure and rich oxygen functional groups.
33581680	9	22	contain	has	1074:1076	arg1	β-CD/GO					1066:1072	β-CD/GO	1066:1072	β-CD/GO	1066:1072	The results show that β-CD/GO has a different adsorption capacity from GO under the same adsorption factors.
33581680	9	22	contain	has	1074:1076	arg2	capacity					1101:1108	a different adsorption capacity	1078:1108	a different adsorption capacity from GO	1078:1116	The results show that β-CD/GO has a different adsorption capacity from GO under the same adsorption factors.
33581680	5	23	dep	Fourier	614:620	arg1	transform					622:630	transform	622:630	transform infrared spectroscopy (FT-IR), energy-dispersive X-ray (XRD), scanning electron (SEM) and thermogravimetric analysis (TGA)	622:753	GO and β-CD were characterized by Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray (XRD), scanning electron (SEM) and thermogravimetric analysis (TGA).
33581680	4	24	theme	β-CD	553:556	arg1	method					572:577	β-cyclodextrin(β-CD) crosslinking method	538:577	β-cyclodextrin(β-CD) crosslinking method	538:577	On this basis, β-cyclodextrin/graphene oxide composite (β-CD/GO) was prepared by modifying graphene oxide via β-cyclodextrin(β-CD) crosslinking method.
33581680	10	25	dep	%	1368:1368	arg1	to					1370:1371	to	1370:1371	to	1370:1371	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	10	26	theme	adsorbent	1273:1281	arg1	concentration					1256:1268	the concentration	1252:1268	the concentration of adsorbent	1252:1281	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	10	26	theme	adsorbent	1273:1281	arg1	0.04 g/L					1286:1293	0.04 g/L	1286:1293	0.04 g/L	1286:1293	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	1	27	theme	bounteous	192:200	arg1	structure					202:210	bounteous structure	192:210	bounteous structure	192:210	Graphene oxide (GO) and GO-based materials have shown excellent adsorption properties because of bounteous structure and rich oxygen functional groups.
33581680	3	28	theme	modified	365:372	arg1	method					382:387	modified Hummers method	365:387	modified Hummers method using graphite powder as raw material	365:425	GO was prepared by modified Hummers method using graphite powder as raw material.
33581680	13	29	from	removal	1582:1588	arg1	efficient					1557:1565	efficient	1557:1565	efficient	1557:1565	In these tests, β-CD/GO was suggested to be more efficient than GO in the removal of organic dyes.
33581680	12	30	with	elution	1477:1483	arg1	alcohol					1499:1505	absolute alcohol	1490:1505	absolute alcohol	1490:1505	β-CD/GO can be effectively regenerated by elution with absolute alcohol.
33581680	3	31	theme	Hummers	374:380	arg1	method					382:387	modified Hummers method	365:387	modified Hummers method using graphite powder as raw material	365:425	GO was prepared by modified Hummers method using graphite powder as raw material.
33581680	4	32	theme	crosslinking	559:570	arg1	method					572:577	β-cyclodextrin(β-CD) crosslinking method	538:577	β-cyclodextrin(β-CD) crosslinking method	538:577	On this basis, β-cyclodextrin/graphene oxide composite (β-CD/GO) was prepared by modifying graphene oxide via β-cyclodextrin(β-CD) crosslinking method.
33581680	1	33	theme	adsorption	159:168	arg1	properties					170:179	excellent adsorption properties	149:179	excellent adsorption properties	149:179	Graphene oxide (GO) and GO-based materials have shown excellent adsorption properties because of bounteous structure and rich oxygen functional groups.
33581680	5	34	theme	scanning	694:701	arg1	SEM					713:715	SEM	713:715	SEM	713:715	GO and β-CD were characterized by Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray (XRD), scanning electron (SEM) and thermogravimetric analysis (TGA).
33581680	5	34	theme	scanning	694:701	arg1	electron					703:710	scanning electron	694:710	scanning electron (SEM)	694:716	GO and β-CD were characterized by Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray (XRD), scanning electron (SEM) and thermogravimetric analysis (TGA).
33581680	2	35	theme	Many	247:250	arg1	studies					252:258	Many studies	247:258	Many studies	247:258	Many studies have shown that GO are utilized as adsorbents to remove organic dyes from wastewater.
33581680	1	36	theme	rich	216:219	arg1	groups					239:244	rich oxygen functional groups	216:244	rich oxygen functional groups	216:244	Graphene oxide (GO) and GO-based materials have shown excellent adsorption properties because of bounteous structure and rich oxygen functional groups.
33581680	3	37	theme	raw	414:416	arg1	material					418:425	raw material	414:425	raw material	414:425	GO was prepared by modified Hummers method using graphite powder as raw material.
33581680	12	38	theme	absolute	1490:1497	arg1	alcohol					1499:1505	absolute alcohol	1490:1505	absolute alcohol	1490:1505	β-CD/GO can be effectively regenerated by elution with absolute alcohol.
33581680	0	39	theme	oxide	39:43	arg1	Preparation					0:10	Preparation	0:10	Preparation of β-cyclodextrin/graphene oxide and its adsorption properties for methylene blue.	0:93	Preparation of β-cyclodextrin/graphene oxide and its adsorption properties for methylene blue.
33581680	9	40	theme	different	1080:1088	arg1	capacity					1101:1108	a different adsorption capacity	1078:1108	a different adsorption capacity from GO	1078:1116	The results show that β-CD/GO has a different adsorption capacity from GO under the same adsorption factors.
33581680	1	41	theme	oxygen	221:226	arg1	groups					239:244	rich oxygen functional groups	216:244	rich oxygen functional groups	216:244	Graphene oxide (GO) and GO-based materials have shown excellent adsorption properties because of bounteous structure and rich oxygen functional groups.
33581680	0	42	theme	properties	64:73	arg1	Preparation					0:10	Preparation	0:10	Preparation of β-cyclodextrin/graphene oxide and its adsorption properties for methylene blue.	0:93	Preparation of β-cyclodextrin/graphene oxide and its adsorption properties for methylene blue.
33581680	4	43	theme	graphene	519:526	arg1	oxide					528:532	graphene oxide	519:532	graphene oxide	519:532	On this basis, β-cyclodextrin/graphene oxide composite (β-CD/GO) was prepared by modifying graphene oxide via β-cyclodextrin(β-CD) crosslinking method.
33581680	5	44	theme	energy-dispersive	663:679	arg1	XRD					688:690	XRD	688:690	XRD	688:690	GO and β-CD were characterized by Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray (XRD), scanning electron (SEM) and thermogravimetric analysis (TGA).
33581680	5	44	theme	energy-dispersive	663:679	arg1	X-ray					681:685	energy-dispersive X-ray	663:685	energy-dispersive X-ray (XRD)	663:691	GO and β-CD were characterized by Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray (XRD), scanning electron (SEM) and thermogravimetric analysis (TGA).
33581680	4	45	theme	β-cyclodextrin/graphene	443:465	arg1	β-CD/GO					484:490	β-CD/GO	484:490	β-CD/GO	484:490	On this basis, β-cyclodextrin/graphene oxide composite (β-CD/GO) was prepared by modifying graphene oxide via β-cyclodextrin(β-CD) crosslinking method.
33581680	4	45	theme	β-cyclodextrin/graphene	443:465	arg1	oxide					467:471	β-cyclodextrin/graphene oxide composite	443:481	β-cyclodextrin/graphene oxide composite (β-CD/GO)	443:491	On this basis, β-cyclodextrin/graphene oxide composite (β-CD/GO) was prepared by modifying graphene oxide via β-cyclodextrin(β-CD) crosslinking method.
33581680	9	46	theme	adsorption	1090:1099	arg1	capacity					1101:1108	a different adsorption capacity	1078:1108	a different adsorption capacity from GO	1078:1116	The results show that β-CD/GO has a different adsorption capacity from GO under the same adsorption factors.
33581680	0	47	theme	adsorption	53:62	arg1	properties					64:73	its adsorption properties	49:73	its adsorption properties	49:73	Preparation of β-cyclodextrin/graphene oxide and its adsorption properties for methylene blue.
33581680	4	48	theme	β-cyclodextrin	538:551	arg1	method					572:577	β-cyclodextrin(β-CD) crosslinking method	538:577	β-cyclodextrin(β-CD) crosslinking method	538:577	On this basis, β-cyclodextrin/graphene oxide composite (β-CD/GO) was prepared by modifying graphene oxide via β-cyclodextrin(β-CD) crosslinking method.
33581680	7	49	theme	adsorption	898:907	arg1	time					909:912	adsorption time	898:912	adsorption time	898:912	The factors affecting the study include the temperature, adsorption time, amount of adsorbent and system pH value.
33581680	13	50	theme	dyes	1601:1604	arg1	removal					1582:1588	the removal	1578:1588	the removal of organic dyes	1578:1604	In these tests, β-CD/GO was suggested to be more efficient than GO in the removal of organic dyes.
33581680	11	51	theme	adsorption	1390:1399	arg1	capacity					1401:1408	The maximum adsorption capacity	1378:1408	The maximum adsorption capacity of β-CD/GO	1378:1419	The maximum adsorption capacity of β-CD/GO is 76.4 mg/g.
33581680	11	51	theme	adsorption	1390:1399	arg1	76.4 mg/g					1424:1432	76.4 mg/g	1424:1432	76.4 mg/g	1424:1432	The maximum adsorption capacity of β-CD/GO is 76.4 mg/g.
33581680	6	52	theme	blue	817:820	arg1	methylene					807:815	methylene blue	807:820	methylene blue (MB)	807:825	Their adsorbents properties have been studied with methylene blue (MB) as adsorbate.
33581680	6	52	theme	blue	817:820	arg1	MB					823:824	MB	823:824	MB	823:824	Their adsorbents properties have been studied with methylene blue (MB) as adsorbate.
33581680	1	53	theme	GO-based	119:126	arg1	materials					128:136	GO-based materials	119:136	GO-based materials	119:136	Graphene oxide (GO) and GO-based materials have shown excellent adsorption properties because of bounteous structure and rich oxygen functional groups.
33581680	1	54	theme	functional	228:237	arg1	groups					239:244	rich oxygen functional groups	216:244	rich oxygen functional groups	216:244	Graphene oxide (GO) and GO-based materials have shown excellent adsorption properties because of bounteous structure and rich oxygen functional groups.
33581680	13	55	theme	organic	1593:1599	arg1	dyes					1601:1604	organic dyes	1593:1604	organic dyes	1593:1604	In these tests, β-CD/GO was suggested to be more efficient than GO in the removal of organic dyes.
33581680	7	56	theme	pH	946:947	arg1	value					949:953	system pH value	939:953	system pH value	939:953	The factors affecting the study include the temperature, adsorption time, amount of adsorbent and system pH value.
33581680	10	57	theme	reaction	1189:1196	arg1	temperature					1198:1208	the reaction temperature	1185:1208	the reaction temperature	1185:1208	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	10	57	theme	reaction	1189:1196	arg1	70 °C					1213:1217	70 °C	1213:1217	70 °C	1213:1217	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	5	58	theme	thermogravimetric	722:738	arg1	analysis					740:747	thermogravimetric analysis	722:747	thermogravimetric analysis (TGA)	722:753	GO and β-CD were characterized by Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray (XRD), scanning electron (SEM) and thermogravimetric analysis (TGA).
33581680	5	58	theme	thermogravimetric	722:738	arg1	TGA					750:752	TGA	750:752	TGA	750:752	GO and β-CD were characterized by Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray (XRD), scanning electron (SEM) and thermogravimetric analysis (TGA).
33581680	11	59	theme	β-CD/GO	1413:1419	arg1	capacity					1401:1408	The maximum adsorption capacity	1378:1408	The maximum adsorption capacity of β-CD/GO	1378:1419	The maximum adsorption capacity of β-CD/GO is 76.4 mg/g.
33581680	11	59	theme	β-CD/GO	1413:1419	arg1	76.4 mg/g					1424:1432	76.4 mg/g	1424:1432	76.4 mg/g	1424:1432	The maximum adsorption capacity of β-CD/GO is 76.4 mg/g.
33581680	10	60	dep	conditions	1173:1182	arg1	concentration					1256:1268	the concentration	1252:1268	the concentration of adsorbent	1252:1281	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	10	60	dep	conditions	1173:1182	arg1	temperature					1198:1208	the reaction temperature	1185:1208	the reaction temperature	1185:1208	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	10	60	dep	conditions	1173:1182	arg1	time					1233:1236	the reaction time	1220:1236	the reaction time	1220:1236	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	10	60	dep	conditions	1173:1182	arg1	60 min					1241:1246	60 min	1241:1246	60 min	1241:1246	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	10	60	dep	conditions	1173:1182	arg1	0.04 g/L					1286:1293	0.04 g/L	1286:1293	0.04 g/L	1286:1293	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	10	60	dep	conditions	1173:1182	arg1	70 °C					1213:1217	70 °C	1213:1217	70 °C	1213:1217	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	11	61	theme	maximum	1382:1388	arg1	capacity					1401:1408	The maximum adsorption capacity	1378:1408	The maximum adsorption capacity of β-CD/GO	1378:1419	The maximum adsorption capacity of β-CD/GO is 76.4 mg/g.
33581680	11	61	theme	maximum	1382:1388	arg1	76.4 mg/g					1424:1432	76.4 mg/g	1424:1432	76.4 mg/g	1424:1432	The maximum adsorption capacity of β-CD/GO is 76.4 mg/g.
33581680	3	62	theme	graphite	395:402	arg1	powder					404:409	graphite powder	395:409	graphite powder	395:409	GO was prepared by modified Hummers method using graphite powder as raw material.
33581680	0	63	theme	β-cyclodextrin/graphene	15:37	arg1	oxide					39:43	β-cyclodextrin/graphene oxide	15:43	β-cyclodextrin/graphene oxide	15:43	Preparation of β-cyclodextrin/graphene oxide and its adsorption properties for methylene blue.
33581680	10	64	theme	removal	1301:1307	arg1	efficiency					1309:1318	the removal efficiency	1297:1318	the removal efficiency of β-CD/GO	1297:1329	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	10	64	theme	removal	1301:1307	arg1	higher					1338:1343	higher	1338:1343	higher	1338:1343	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	10	65	theme	reaction	1224:1231	arg1	60 min					1241:1246	60 min	1241:1246	60 min	1241:1246	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
33581680	10	65	theme	reaction	1224:1231	arg1	time					1233:1236	the reaction time	1220:1236	the reaction time	1220:1236	Under the optimized conditions (the reaction temperature is 70 °C, the reaction time is 60 min and the concentration of adsorbent is 0.04 g/L), the removal efficiency of β-CD/GO is 20% higher than that of GO from 70% to 90%.
34352234	1	0	theme	ions	345:348	arg1	efficiency					314:323	the removal efficiency	302:323	the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions	302:406	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	6	1	theme	adsorption	1489:1498	arg1	capacity					1500:1507	the maximum adsorption capacity	1477:1507	the maximum adsorption capacity	1477:1507	The isotherm model so-called Langmuir, Freundlich, and Temkin model was utilized to plot the experimental adsorption dataset to infer the maximum adsorption capacity.
34352234	1	2	theme	biomaterial	142:152	arg1	powder					209:214	biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	142:214	biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	142:214	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	5	3	theme	fast	1203:1206	arg1	kinetics					1222:1229	fast rate sorption kinetics	1203:1229	fast rate sorption kinetics	1203:1229	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	3	4	theme	functional	688:697	arg1	group					699:703	the functional group	684:703	the functional group presents in the compound	684:728	The behavior of the functional group presents in the compound was discussed using the FTIR technique.
34352234	7	5	dep	treated	1570:1576	arg1	beads					1564:1568	beads	1564:1568	beads	1564:1568	Based on this model, the adsorption properties of the beads treated compound was determined by plotting the graphs in which sorption intensity (n) which implies expected sorption, and the correlation value are 1.989, 0.998, and 0,981 respectively.
34352234	2	6	theme	surface	596:602	arg1	morphology					604:613	its surface morphology	592:613	its surface morphology	592:613	Structural analysis of the entitled compound was evaluated by the PXRD techniques and its surface morphology was inferred by the following techniques: TEM, EDAX.
34352234	6	7	dep	experimental	1436:1447	arg1	adsorption					1449:1458	adsorption	1449:1458	adsorption	1449:1458	The isotherm model so-called Langmuir, Freundlich, and Temkin model was utilized to plot the experimental adsorption dataset to infer the maximum adsorption capacity.
34352234	1	8	theme	activated	154:162	arg1	powder					209:214	biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	142:214	biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	142:214	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	5	9	theme	rate	1208:1211	arg1	kinetics					1222:1229	fast rate sorption kinetics	1203:1229	fast rate sorption kinetics	1203:1229	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	1	10	theme	experimental	258:269	arg1	techniques					271:280	experimental techniques	258:280	experimental techniques	258:280	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	0	11	theme	kinetic	82:88	arg1	study					108:112	A kinetic and thermodynamic study	80:112	Adsorption of copper and nickel by using sawdust chitosan nanocomposite beads - A kinetic and thermodynamic study.	0:113	Adsorption of copper and nickel by using sawdust chitosan nanocomposite beads - A kinetic and thermodynamic study.
34352234	5	12	theme	metal	1095:1099	arg1	ions					1101:1104	metal ions	1095:1104	metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite	1095:1340	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	4	13	theme	copper	851:856	arg1	pH					799:800	pH	799:800	pH	799:800	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	4	13	theme	copper	851:856	arg1	concentration					834:846	initial concentration	826:846	initial concentration	826:846	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	4	13	theme	copper	851:856	arg1	temperature					809:819	temperature	809:819	temperature	809:819	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	4	13	theme	copper	851:856	arg1	dosage					791:796	dosage	791:796	dosage	791:796	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	4	13	theme	copper	851:856	arg1	time					803:806	time	803:806	time	803:806	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	5	14	theme	sorption	1213:1220	arg1	kinetics					1222:1229	fast rate sorption kinetics	1203:1229	fast rate sorption kinetics	1203:1229	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	6	15	theme	Temkin	1398:1403	arg1	model					1405:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model was utilized to plot the experimental adsorption dataset to infer the maximum adsorption capacity.
34352234	7	16	theme	correlation	1698:1708	arg1	value					1710:1714	the correlation value	1694:1714	the correlation value	1694:1714	Based on this model, the adsorption properties of the beads treated compound was determined by plotting the graphs in which sorption intensity (n) which implies expected sorption, and the correlation value are 1.989, 0.998, and 0,981 respectively.
34352234	7	17	theme	adsorption	1535:1544	arg1	properties					1546:1555	the adsorption properties	1531:1555	the adsorption properties of the beads treated compound	1531:1585	Based on this model, the adsorption properties of the beads treated compound was determined by plotting the graphs in which sorption intensity (n) which implies expected sorption, and the correlation value are 1.989, 0.998, and 0,981 respectively.
34352234	5	18	theme	Ni+	1266:1268	arg1	involvement					1245:1255	strong involvement	1238:1255	strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite	1238:1340	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	5	19	theme	activated	1167:1175	arg1	carbon					1177:1182	activated carbon	1167:1182	activated carbon	1167:1182	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	0	20	theme	thermodynamic	94:106	arg1	study					108:112	A kinetic and thermodynamic study	80:112	Adsorption of copper and nickel by using sawdust chitosan nanocomposite beads - A kinetic and thermodynamic study.	0:113	Adsorption of copper and nickel by using sawdust chitosan nanocomposite beads - A kinetic and thermodynamic study.
34352234	5	21	theme	appropriate	1053:1063	arg1	area					1073:1076	an appropriate surface area	1050:1076	an appropriate surface area	1050:1076	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	1	22	theme	surface-modified	425:440	arg1	carbon					452:457	the surface-modified activated carbon	421:457	the surface-modified activated carbon	421:457	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	6	23	theme	isotherm	1347:1354	arg1	model					1405:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model was utilized to plot the experimental adsorption dataset to infer the maximum adsorption capacity.
34352234	1	24	theme	Sawdust-Chitosan	164:179	arg1	powder					209:214	biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	142:214	biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	142:214	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	2	25	theme	Structural	506:515	arg1	analysis					517:524	Structural analysis	506:524	Structural analysis of the entitled compound	506:549	Structural analysis of the entitled compound was evaluated by the PXRD techniques and its surface morphology was inferred by the following techniques: TEM, EDAX.
34352234	3	26	theme	group	699:703	arg1	behavior					672:679	The behavior	668:679	The behavior of the functional group presents in the compound	668:728	The behavior of the functional group presents in the compound was discussed using the FTIR technique.
34352234	1	27	theme	activated	442:450	arg1	carbon					452:457	the surface-modified activated carbon	421:457	the surface-modified activated carbon	421:457	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	1	28	theme	nanocomposite	181:193	arg1	powder					209:214	biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	142:214	biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	142:214	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	5	29	contain	have	1045:1048	arg2	area					1073:1076	an appropriate surface area	1050:1076	an appropriate surface area	1050:1076	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	5	29	contain	have	1045:1048	arg1	beads					1022:1026	the cellulose and chitosan beads	995:1026	the cellulose and chitosan beads complex material	995:1043	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	4	30	theme	elements	940:947	arg1	effect					910:915	the effect	906:915	the effect of adsorption of heavy elements that exist in the portable solution	906:983	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	4	31	theme	heavy	934:938	arg1	elements					940:947	heavy elements	934:947	heavy elements that exist in the portable solution	934:983	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	1	32	theme	beads	195:199	arg1	powder					209:214	biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	142:214	biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	142:214	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	7	33	theme	treated	1570:1576	arg1	compound					1578:1585	the beads treated compound	1560:1585	the beads treated compound	1560:1585	Based on this model, the adsorption properties of the beads treated compound was determined by plotting the graphs in which sorption intensity (n) which implies expected sorption, and the correlation value are 1.989, 0.998, and 0,981 respectively.
34352234	4	34	theme	portable	967:974	arg1	solution					976:983	the portable solution	963:983	the portable solution	963:983	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	6	35	theme	maximum	1481:1487	arg1	capacity					1500:1507	the maximum adsorption capacity	1477:1507	the maximum adsorption capacity	1477:1507	The isotherm model so-called Langmuir, Freundlich, and Temkin model was utilized to plot the experimental adsorption dataset to infer the maximum adsorption capacity.
34352234	4	36	theme	initial	826:832	arg1	concentration					834:846	initial concentration	826:846	initial concentration	826:846	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	4	36	theme	initial	826:832	arg1	dosage					791:796	dosage	791:796	dosage	791:796	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	6	37	theme	Langmuir	1372:1379	arg1	model					1405:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model was utilized to plot the experimental adsorption dataset to infer the maximum adsorption capacity.
34352234	7	38	theme	compound	1578:1585	arg1	properties					1546:1555	the adsorption properties	1531:1555	the adsorption properties of the beads treated compound	1531:1585	Based on this model, the adsorption properties of the beads treated compound was determined by plotting the graphs in which sorption intensity (n) which implies expected sorption, and the correlation value are 1.989, 0.998, and 0,981 respectively.
34352234	2	39	theme	following	635:643	arg1	techniques					645:654	the following techniques	631:654	the following techniques: TEM, EDAX	631:665	Structural analysis of the entitled compound was evaluated by the PXRD techniques and its surface morphology was inferred by the following techniques: TEM, EDAX.
34352234	1	40	theme	SDNCB	202:206	arg1	powder					209:214	biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	142:214	biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	142:214	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	0	41	theme	copper	14:19	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of copper and nickel by using sawdust chitosan nanocomposite beads - A kinetic and thermodynamic study.	0:113	Adsorption of copper and nickel by using sawdust chitosan nanocomposite beads - A kinetic and thermodynamic study.
34352234	1	42	theme	Cu	372:373	arg1	ions					380:383	Cu (II) ions	372:383	Cu (II) ions from aqueous solutions	372:406	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	5	43	theme	surface	1065:1071	arg1	area					1073:1076	an appropriate surface area	1050:1076	an appropriate surface area	1050:1076	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	6	44	theme	experimental	1436:1447	arg1	dataset					1460:1466	the experimental adsorption dataset	1432:1466	the experimental adsorption dataset	1432:1466	The isotherm model so-called Langmuir, Freundlich, and Temkin model was utilized to plot the experimental adsorption dataset to infer the maximum adsorption capacity.
34352234	6	45	theme	model	1356:1360	arg1	model					1405:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model was utilized to plot the experimental adsorption dataset to infer the maximum adsorption capacity.
34352234	1	46	theme	removal	306:312	arg1	efficiency					314:323	the removal efficiency	302:323	the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions	302:406	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	2	47	theme	compound	542:549	arg1	analysis					517:524	Structural analysis	506:524	Structural analysis of the entitled compound	506:549	Structural analysis of the entitled compound was evaluated by the PXRD techniques and its surface morphology was inferred by the following techniques: TEM, EDAX.
34352234	7	48	theme	sorption	1634:1641	arg1	n					1654:1654	n	1654:1654	n	1654:1654	Based on this model, the adsorption properties of the beads treated compound was determined by plotting the graphs in which sorption intensity (n) which implies expected sorption, and the correlation value are 1.989, 0.998, and 0,981 respectively.
34352234	7	48	theme	sorption	1634:1641	arg1	intensity					1643:1651	sorption intensity	1634:1651	sorption intensity (n) which implies expected sorption, and the correlation value	1634:1714	Based on this model, the adsorption properties of the beads treated compound was determined by plotting the graphs in which sorption intensity (n) which implies expected sorption, and the correlation value are 1.989, 0.998, and 0,981 respectively.
34352234	1	49	theme	powder	209:214	arg1	behavior					130:137	The adsorption behavior	115:137	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	115:214	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	0	50	theme	nickel	25:30	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of copper and nickel by using sawdust chitosan nanocomposite beads - A kinetic and thermodynamic study.	0:113	Adsorption of copper and nickel by using sawdust chitosan nanocomposite beads - A kinetic and thermodynamic study.
34352234	3	51	dep	group	699:703	arg1	presents					705:712	presents	705:712	presents in the compound	705:728	The behavior of the functional group presents in the compound was discussed using the FTIR technique.
34352234	2	52	theme	entitled	533:540	arg1	compound					542:549	the entitled compound	529:549	the entitled compound	529:549	Structural analysis of the entitled compound was evaluated by the PXRD techniques and its surface morphology was inferred by the following techniques: TEM, EDAX.
34352234	1	53	theme	cost-effective	466:479	arg1	method					498:503	the cost-effective non-conventional method	462:503	the cost-effective non-conventional method	462:503	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	3	54	theme	FTIR	754:757	arg1	technique					759:767	the FTIR technique	750:767	the FTIR technique	750:767	The behavior of the functional group presents in the compound was discussed using the FTIR technique.
34352234	0	55	theme	sawdust	41:47	arg1	beads					72:76	sawdust chitosan nanocomposite beads	41:76	sawdust chitosan nanocomposite beads	41:76	Adsorption of copper and nickel by using sawdust chitosan nanocomposite beads - A kinetic and thermodynamic study.
34352234	5	56	theme	removal	1106:1112	arg1	efficiency					1114:1123	removal efficiency	1106:1123	removal efficiency	1106:1123	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	4	57	theme	nickel	862:867	arg1	pH					799:800	pH	799:800	pH	799:800	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	4	57	theme	nickel	862:867	arg1	concentration					834:846	initial concentration	826:846	initial concentration	826:846	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	4	57	theme	nickel	862:867	arg1	temperature					809:819	temperature	809:819	temperature	809:819	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	4	57	theme	nickel	862:867	arg1	dosage					791:796	dosage	791:796	dosage	791:796	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	4	57	theme	nickel	862:867	arg1	time					803:806	time	803:806	time	803:806	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	1	58	from	solutions	398:406	arg1	II					364:365	II	364:365	II	364:365	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	1	58	from	solutions	398:406	arg1	Ni					360:361	Ni	360:361	Ni (II)	360:366	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	1	58	from	solutions	398:406	arg1	ions					380:383	Cu (II) ions	372:383	Cu (II) ions from aqueous solutions	372:406	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	5	59	from	involvement	1245:1255	arg1	composite					1332:1340	the bio composite	1324:1340	the bio composite	1324:1340	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	1	60	theme	non-conventional	481:496	arg1	method					498:503	the cost-effective non-conventional method	462:503	the cost-effective non-conventional method	462:503	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	5	61	dep	ions	1101:1104	arg1	appreciable					1134:1144	appreciable	1134:1144	appreciable	1134:1144	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	2	62	theme	PXRD	572:575	arg1	techniques					577:586	the PXRD techniques	568:586	the PXRD techniques	568:586	Structural analysis of the entitled compound was evaluated by the PXRD techniques and its surface morphology was inferred by the following techniques: TEM, EDAX.
34352234	5	63	theme	bio	1328:1330	arg1	composite					1332:1340	the bio composite	1324:1340	the bio composite	1324:1340	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	4	64	theme	adsorption	920:929	arg1	effect					910:915	the effect	906:915	the effect of adsorption of heavy elements that exist in the portable solution	906:983	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	1	65	theme	heavy	333:337	arg1	Ni					360:361	Ni	360:361	Ni (II)	360:366	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	1	65	theme	heavy	333:337	arg1	ions					345:348	some heavy metal ions	328:348	some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions	328:406	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	1	65	theme	heavy	333:337	arg1	ions					380:383	Cu (II) ions	372:383	Cu (II) ions from aqueous solutions	372:406	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	5	66	theme	cellulose	999:1007	arg1	beads					1022:1026	the cellulose and chitosan beads	995:1026	the cellulose and chitosan beads complex material	995:1043	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	6	67	used	utilized	1415:1422	arg2	model					1405:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model was utilized to plot the experimental adsorption dataset to infer the maximum adsorption capacity.
34352234	7	68	from	1.989	1720:1724	arg1	graphs					1618:1623	the graphs	1614:1623	the graphs in which sorption intensity (n) which implies expected sorption, and the correlation value are 1.989, 0.998, and 0,981 respectively	1614:1755	Based on this model, the adsorption properties of the beads treated compound was determined by plotting the graphs in which sorption intensity (n) which implies expected sorption, and the correlation value are 1.989, 0.998, and 0,981 respectively.
34352234	7	69	theme	expected	1671:1678	arg1	sorption					1680:1687	expected sorption	1671:1687	expected sorption	1671:1687	Based on this model, the adsorption properties of the beads treated compound was determined by plotting the graphs in which sorption intensity (n) which implies expected sorption, and the correlation value are 1.989, 0.998, and 0,981 respectively.
34352234	5	70	theme	carbon	1177:1182	arg1	action					1157:1162	the action	1153:1162	the action	1153:1162	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	1	71	theme	aqueous	390:396	arg1	solutions					398:406	aqueous solutions	390:406	aqueous solutions	390:406	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	4	72	theme	Such	770:773	arg1	parameters					775:784	Such parameters	770:784	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel	770:867	Such parameters like dosage, pH, time, temperature, and initial concentration of copper and nickel were associated with this to examine the effect of adsorption of heavy elements that exist in the portable solution.
34352234	1	73	theme	adsorption	119:128	arg1	behavior					130:137	The adsorption behavior	115:137	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder	115:214	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	6	74	theme	so-called	1362:1370	arg1	model					1405:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model was utilized to plot the experimental adsorption dataset to infer the maximum adsorption capacity.
34352234	0	75	theme	nanocomposite	58:70	arg1	beads					72:76	sawdust chitosan nanocomposite beads	41:76	sawdust chitosan nanocomposite beads	41:76	Adsorption of copper and nickel by using sawdust chitosan nanocomposite beads - A kinetic and thermodynamic study.
34352234	5	76	theme	chitosan	1013:1020	arg1	beads					1022:1026	the cellulose and chitosan beads	995:1026	the cellulose and chitosan beads complex material	995:1043	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	5	77	theme	strong	1238:1243	arg1	involvement					1245:1255	strong involvement	1238:1255	strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite	1238:1340	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	5	78	dep	beads	1022:1026	arg1	complex					1028:1034	complex	1028:1034	complex	1028:1034	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	0	79	theme	chitosan	49:56	arg1	beads					72:76	sawdust chitosan nanocomposite beads	41:76	sawdust chitosan nanocomposite beads	41:76	Adsorption of copper and nickel by using sawdust chitosan nanocomposite beads - A kinetic and thermodynamic study.
34352234	1	80	theme	metal	339:343	arg1	Ni					360:361	Ni	360:361	Ni (II)	360:366	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	1	80	theme	metal	339:343	arg1	ions					345:348	some heavy metal ions	328:348	some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions	328:406	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	1	80	theme	metal	339:343	arg1	ions					380:383	Cu (II) ions	372:383	Cu (II) ions from aqueous solutions	372:406	The adsorption behavior of biomaterial activated Sawdust-Chitosan nanocomposite beads (SDNCB) powder was investigated along with synthesis and experimental techniques approaches to study the removal efficiency of some heavy metal ions including Ni (II) and Cu (II) ions from aqueous solutions by assessing the surface-modified activated carbon by the cost-effective non-conventional method.
34352234	0	81	dep	Adsorption	0:9	arg1	study					108:112	A kinetic and thermodynamic study	80:112	Adsorption of copper and nickel by using sawdust chitosan nanocomposite beads - A kinetic and thermodynamic study.	0:113	Adsorption of copper and nickel by using sawdust chitosan nanocomposite beads - A kinetic and thermodynamic study.
34352234	5	82	theme	functional	1303:1312	arg1	groups					1314:1319	cellulose and chitosan's functional groups	1278:1319	cellulose and chitosan's functional groups	1278:1319	Further, the cellulose and chitosan beads complex material have an appropriate surface area, it demonstrated metal ions removal efficiency was more appreciable due to the action of activated carbon, where this showed fast rate sorption kinetics due to strong involvement of Cu+ & Ni+ towards cellulose and chitosan's functional groups in the bio composite.
34352234	6	83	theme	Freundlich	1382:1391	arg1	model					1405:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model	1343:1409	The isotherm model so-called Langmuir, Freundlich, and Temkin model was utilized to plot the experimental adsorption dataset to infer the maximum adsorption capacity.
34352234	2	84	dep	techniques	645:654	arg1	EDAX					662:665	EDAX	662:665	EDAX	662:665	Structural analysis of the entitled compound was evaluated by the PXRD techniques and its surface morphology was inferred by the following techniques: TEM, EDAX.
34352234	2	84	dep	techniques	645:654	arg1	TEM					657:659	TEM	657:659	TEM	657:659	Structural analysis of the entitled compound was evaluated by the PXRD techniques and its surface morphology was inferred by the following techniques: TEM, EDAX.
34200653	5	0	contain	had	844:846	arg1	aerogel					836:842	CNGA/C-AgNPs packaging aerogel	813:842	CNGA/C-AgNPs packaging aerogel	813:842	Although AgNPs was slowly released, CNGA/C-AgNPs packaging aerogel had an obvious antibacterial effect on E. coli and S. aureus.
34200653	5	0	contain	had	844:846	arg2	effect					873:878	an obvious antibacterial effect	848:878	an obvious antibacterial effect	848:878	Although AgNPs was slowly released, CNGA/C-AgNPs packaging aerogel had an obvious antibacterial effect on E. coli and S. aureus.
34200653	7	1	theme	packaging	1048:1056	arg1	aerogel					1058:1064	the prepared packaging aerogel	1035:1064	the prepared packaging aerogel	1035:1064	Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.
34200653	1	2	theme	vegetables	202:211	arg1	transportation					173:186	transportation	173:186	transportation	173:186	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	1	2	theme	vegetables	202:211	arg1	storage					161:167	storage	161:167	storage	161:167	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	4	3	theme	packaging	648:656	arg1	aerogel					658:664	The CNGA/C-AgNPs packaging aerogel	631:664	The CNGA/C-AgNPs packaging aerogel	631:664	The CNGA/C-AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%.
34200653	7	4	theme	new	1199:1201	arg1	idea					1203:1206	a new idea	1197:1206	a new idea for the development of food intelligent packaging	1197:1256	Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.
34200653	2	5	theme	carboxymethyl	322:334	arg1	nanocellulose					336:348	carboxymethyl nanocellulose	322:348	carboxymethyl nanocellulose	322:348	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	4	6	theme	good	670:673	arg1	cushioning					675:684	good cushioning	670:684	good cushioning	670:684	The CNGA/C-AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%.
34200653	3	7	theme	dual-function	542:554	arg1	aerogel					566:572	the 3D-printed cushioning-antibacterial dual-function packaging aerogel	502:572	the 3D-printed cushioning-antibacterial dual-function packaging aerogel with a shell-core structure (CNGA/C-AgNPs)	502:615	Thus, the 3D-printed cushioning-antibacterial dual-function packaging aerogel with a shell-core structure (CNGA/C-AgNPs) was obtained.
34200653	7	8	theme	prepared	1039:1046	arg1	aerogel					1058:1064	the prepared packaging aerogel	1035:1064	the prepared packaging aerogel	1035:1064	Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.
34200653	1	9	theme	antibacterial	109:121	arg1	Cushioning					94:103	Cushioning	94:103	Cushioning	94:103	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	1	9	theme	antibacterial	109:121	arg1	packaging					123:131	antibacterial packaging	109:131	antibacterial packaging	109:131	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	1	9	theme	antibacterial	109:121	arg1	requirements					141:152	the requirements	137:152	the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process	137:294	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	4	10	theme	resilience	742:751	arg1	%					774:774	more than 90%	762:774	more than 90%	762:774	The CNGA/C-AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%.
34200653	4	10	theme	resilience	742:751	arg1	rate					753:756	the average compression resilience rate	718:756	the average compression resilience rate	718:756	The CNGA/C-AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%.
34200653	5	11	theme	CNGA/C-AgNPs	813:824	arg1	aerogel					836:842	CNGA/C-AgNPs packaging aerogel	813:842	CNGA/C-AgNPs packaging aerogel	813:842	Although AgNPs was slowly released, CNGA/C-AgNPs packaging aerogel had an obvious antibacterial effect on E. coli and S. aureus.
34200653	7	12	theme	food	1231:1234	arg1	packaging					1248:1256	food intelligent packaging	1231:1256	food intelligent packaging	1231:1256	Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.
34200653	7	13	theme	technology	1023:1032	arg1	capabilities					995:1006	the customization capabilities	977:1006	the customization capabilities of 3D-printing technology	977:1032	Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.
34200653	1	14	dep	storage	161:167	arg1	the					157:159	the	157:159	the	157:159	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	4	15	theme	compression	730:740	arg1	%					774:774	more than 90%	762:774	more than 90%	762:774	The CNGA/C-AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%.
34200653	4	15	theme	compression	730:740	arg1	rate					753:756	the average compression resilience rate	718:756	the average compression resilience rate	718:756	The CNGA/C-AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%.
34200653	0	16	theme	Nanocellulose-Based	11:29	arg1	Packaging					75:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging	0:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging	0:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging Aerogel.
34200653	0	17	theme	3D-Printed	0:9	arg1	Packaging					75:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging	0:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging	0:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging Aerogel.
34200653	7	18	theme	intelligent	1236:1246	arg1	packaging					1248:1256	food intelligent packaging	1231:1256	food intelligent packaging	1231:1256	Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.
34200653	3	19	with	aerogel	566:572	arg1	CNGA/C-AgNPs					603:614	CNGA/C-AgNPs	603:614	CNGA/C-AgNPs	603:614	Thus, the 3D-printed cushioning-antibacterial dual-function packaging aerogel with a shell-core structure (CNGA/C-AgNPs) was obtained.
34200653	3	19	with	aerogel	566:572	arg1	structure					592:600	a shell-core structure	579:600	a shell-core structure (CNGA/C-AgNPs)	579:615	Thus, the 3D-printed cushioning-antibacterial dual-function packaging aerogel with a shell-core structure (CNGA/C-AgNPs) was obtained.
34200653	2	20	theme	glycerin	351:358	arg1	derivatives					376:386	acrylamide derivatives	365:386	acrylamide derivatives	365:386	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	2	20	theme	glycerin	351:358	arg1	glycerin					351:358	glycerin	351:358	glycerin	351:358	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	2	20	theme	glycerin	351:358	arg1	shell					401:405	the shell	397:405	the shell	397:405	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	2	20	theme	glycerin	351:358	arg1	composite					309:317	the composite	305:317	the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives	305:386	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	2	20	theme	glycerin	351:358	arg1	nanocellulose					336:348	carboxymethyl nanocellulose	322:348	carboxymethyl nanocellulose	322:348	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	0	21	theme	Dual-Function	56:68	arg1	Packaging					75:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging	0:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging	0:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging Aerogel.
34200653	7	22	theme	3D-printing	1011:1021	arg1	technology					1023:1032	3D-printing technology	1011:1032	3D-printing technology	1011:1032	Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.
34200653	2	23	theme	coaxial	464:470	arg1	technology					484:493	coaxial 3D-printing technology	464:493	coaxial 3D-printing technology	464:493	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	4	24	theme	CNGA/C-AgNPs	635:646	arg1	aerogel					658:664	The CNGA/C-AgNPs packaging aerogel	631:664	The CNGA/C-AgNPs packaging aerogel	631:664	The CNGA/C-AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%.
34200653	7	25	theme	aerogels	1172:1179	arg1	microstructure					1154:1167	the microstructure	1150:1167	the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging	1150:1256	Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.
34200653	2	26	theme	nanocellulose	336:348	arg1	derivatives					376:386	acrylamide derivatives	365:386	acrylamide derivatives	365:386	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	2	26	theme	nanocellulose	336:348	arg1	glycerin					351:358	glycerin	351:358	glycerin	351:358	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	2	26	theme	nanocellulose	336:348	arg1	shell					401:405	the shell	397:405	the shell	397:405	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	2	26	theme	nanocellulose	336:348	arg1	composite					309:317	the composite	305:317	the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives	305:386	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	2	26	theme	nanocellulose	336:348	arg1	nanocellulose					336:348	carboxymethyl nanocellulose	322:348	carboxymethyl nanocellulose	322:348	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	3	27	theme	3D-printed	506:515	arg1	aerogel					566:572	the 3D-printed cushioning-antibacterial dual-function packaging aerogel	502:572	the 3D-printed cushioning-antibacterial dual-function packaging aerogel with a shell-core structure (CNGA/C-AgNPs)	502:615	Thus, the 3D-printed cushioning-antibacterial dual-function packaging aerogel with a shell-core structure (CNGA/C-AgNPs) was obtained.
34200653	5	28	theme	obvious	851:857	arg1	effect					873:878	an obvious antibacterial effect	848:878	an obvious antibacterial effect	848:878	Although AgNPs was slowly released, CNGA/C-AgNPs packaging aerogel had an obvious antibacterial effect on E. coli and S. aureus.
34200653	2	29	theme	derivatives	376:386	arg1	derivatives					376:386	acrylamide derivatives	365:386	acrylamide derivatives	365:386	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	2	29	theme	derivatives	376:386	arg1	glycerin					351:358	glycerin	351:358	glycerin	351:358	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	2	29	theme	derivatives	376:386	arg1	shell					401:405	the shell	397:405	the shell	397:405	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	2	29	theme	derivatives	376:386	arg1	composite					309:317	the composite	305:317	the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives	305:386	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	2	29	theme	derivatives	376:386	arg1	nanocellulose					336:348	carboxymethyl nanocellulose	322:348	carboxymethyl nanocellulose	322:348	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	6	30	theme	packaging	933:941	arg1	biodegradable					955:967	biodegradable	955:967	biodegradable	955:967	Moreover, the CNGA/C-AgNPs packaging aerogel was biodegradable.
34200653	6	30	theme	packaging	933:941	arg1	aerogel					943:949	the CNGA/C-AgNPs packaging aerogel	916:949	the CNGA/C-AgNPs packaging aerogel	916:949	Moreover, the CNGA/C-AgNPs packaging aerogel was biodegradable.
34200653	4	31	contain	had	666:668	arg2	performance					701:711	resilience performance	690:711	resilience performance	690:711	The CNGA/C-AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%.
34200653	4	31	contain	had	666:668	arg1	aerogel					658:664	The CNGA/C-AgNPs packaging aerogel	631:664	The CNGA/C-AgNPs packaging aerogel	631:664	The CNGA/C-AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%.
34200653	4	31	contain	had	666:668	arg2	cushioning					675:684	good cushioning	670:684	good cushioning	670:684	The CNGA/C-AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%.
34200653	4	32	theme	average	722:728	arg1	%					774:774	more than 90%	762:774	more than 90%	762:774	The CNGA/C-AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%.
34200653	4	32	theme	average	722:728	arg1	rate					753:756	the average compression resilience rate	718:756	the average compression resilience rate	718:756	The CNGA/C-AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%.
34200653	0	33	theme	Food	70:73	arg1	Packaging					75:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging	0:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging	0:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging Aerogel.
34200653	5	34	theme	antibacterial	859:871	arg1	effect					873:878	an obvious antibacterial effect	848:878	an obvious antibacterial effect	848:878	Although AgNPs was slowly released, CNGA/C-AgNPs packaging aerogel had an obvious antibacterial effect on E. coli and S. aureus.
34200653	6	35	theme	CNGA/C-AgNPs	920:931	arg1	biodegradable					955:967	biodegradable	955:967	biodegradable	955:967	Moreover, the CNGA/C-AgNPs packaging aerogel was biodegradable.
34200653	6	35	theme	CNGA/C-AgNPs	920:931	arg1	aerogel					943:949	the CNGA/C-AgNPs packaging aerogel	916:949	the CNGA/C-AgNPs packaging aerogel	916:949	Moreover, the CNGA/C-AgNPs packaging aerogel was biodegradable.
34200653	0	36	dep	Aerogel	85:91	arg1	Packaging					75:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging	0:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging	0:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging Aerogel.
34200653	1	37	theme	irreversible	251:262	arg1	loss					272:275	the irreversible quality loss	247:275	the irreversible quality loss	247:275	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	3	38	theme	packaging	556:564	arg1	aerogel					566:572	the 3D-printed cushioning-antibacterial dual-function packaging aerogel	502:572	the 3D-printed cushioning-antibacterial dual-function packaging aerogel with a shell-core structure (CNGA/C-AgNPs)	502:615	Thus, the 3D-printed cushioning-antibacterial dual-function packaging aerogel with a shell-core structure (CNGA/C-AgNPs) was obtained.
34200653	2	39	theme	3D-printing	472:482	arg1	technology					484:493	coaxial 3D-printing technology	464:493	coaxial 3D-printing technology	464:493	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	7	40	theme	more	1084:1087	arg1	scenarios					1101:1109	more application scenarios	1084:1109	more application scenarios	1084:1109	Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.
34200653	1	41	theme	storage	161:167	arg1	Cushioning					94:103	Cushioning	94:103	Cushioning	94:103	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	1	41	theme	storage	161:167	arg1	packaging					123:131	antibacterial packaging	109:131	antibacterial packaging	109:131	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	1	41	theme	storage	161:167	arg1	requirements					141:152	the requirements	137:152	the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process	137:294	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	7	42	theme	customization	981:993	arg1	capabilities					995:1006	the customization capabilities	977:1006	the customization capabilities of 3D-printing technology	977:1032	Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.
34200653	7	43	theme	packaging	1248:1256	arg1	development					1216:1226	the development	1212:1226	the development of food intelligent packaging	1212:1256	Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.
34200653	7	44	theme	application	1089:1099	arg1	scenarios					1101:1109	more application scenarios	1084:1109	more application scenarios	1084:1109	Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.
34200653	2	45	theme	acrylamide	365:374	arg1	derivatives					376:386	acrylamide derivatives	365:386	acrylamide derivatives	365:386	Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology.
34200653	1	46	theme	quality	264:270	arg1	loss					272:275	the irreversible quality loss	247:275	the irreversible quality loss	247:275	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	1	47	theme	transportation	173:186	arg1	Cushioning					94:103	Cushioning	94:103	Cushioning	94:103	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	1	47	theme	transportation	173:186	arg1	packaging					123:131	antibacterial packaging	109:131	antibacterial packaging	109:131	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	1	47	theme	transportation	173:186	arg1	requirements					141:152	the requirements	137:152	the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process	137:294	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	3	48	theme	cushioning-antibacterial	517:540	arg1	aerogel					566:572	the 3D-printed cushioning-antibacterial dual-function packaging aerogel	502:572	the 3D-printed cushioning-antibacterial dual-function packaging aerogel with a shell-core structure (CNGA/C-AgNPs)	502:615	Thus, the 3D-printed cushioning-antibacterial dual-function packaging aerogel with a shell-core structure (CNGA/C-AgNPs) was obtained.
34200653	5	49	theme	packaging	826:834	arg1	aerogel					836:842	CNGA/C-AgNPs packaging aerogel	813:842	CNGA/C-AgNPs packaging aerogel	813:842	Although AgNPs was slowly released, CNGA/C-AgNPs packaging aerogel had an obvious antibacterial effect on E. coli and S. aureus.
34200653	3	50	theme	shell-core	581:590	arg1	CNGA/C-AgNPs					603:614	CNGA/C-AgNPs	603:614	CNGA/C-AgNPs	603:614	Thus, the 3D-printed cushioning-antibacterial dual-function packaging aerogel with a shell-core structure (CNGA/C-AgNPs) was obtained.
34200653	3	50	theme	shell-core	581:590	arg1	structure					592:600	a shell-core structure	579:600	a shell-core structure (CNGA/C-AgNPs)	579:615	Thus, the 3D-printed cushioning-antibacterial dual-function packaging aerogel with a shell-core structure (CNGA/C-AgNPs) was obtained.
34200653	0	51	theme	Cushioning-Antibacterial	31:54	arg1	Packaging					75:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging	0:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging	0:83	3D-Printed Nanocellulose-Based Cushioning-Antibacterial Dual-Function Food Packaging Aerogel.
34200653	1	52	theme	fruits	191:196	arg1	transportation					173:186	transportation	173:186	transportation	173:186	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	1	52	theme	fruits	191:196	arg1	storage					161:167	storage	161:167	storage	161:167	Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process.
34200653	4	53	theme	resilience	690:699	arg1	performance					701:711	resilience performance	690:711	resilience performance	690:711	The CNGA/C-AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%.
33596334	7	0	theme	mobile	1226:1231	arg1	additives					1239:1247	acidic/basic mobile phase additives	1213:1247	acidic/basic mobile phase additives	1213:1247	Effect of acidic/basic mobile phase additives was also tested.
33596334	1	1	theme	liquid	335:340	arg1	materials					354:362	chiral rod-like liquid crystalline materials	319:362	chiral rod-like liquid crystalline materials	319:362	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	6	2	theme	pure	1096:1099	arg1	solvents					1109:1116	pure organic solvents	1096:1116	pure organic solvents	1096:1116	Tested mobile phases comprised pure organic solvents and binary and tertiary mixtures of acetonitrile with organic solvents and/or water.
33596334	1	3	theme	temperature	251:261	arg1	effects					204:210	the effects	200:210	the effects of mobile phase composition and column temperature on enantiomer elution order	200:289	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	3	4	theme	stationary	705:714	arg1	tris					626:629	amylose tris	618:629	amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel	618:689	Experiments were carried out in polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase.
33596334	3	4	theme	stationary	705:714	arg1	phase					716:720	the chiral stationary phase	694:720	the chiral stationary phase	694:720	Experiments were carried out in polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase.
33596334	1	5	theme	crystalline	342:352	arg1	materials					354:362	chiral rod-like liquid crystalline materials	319:362	chiral rod-like liquid crystalline materials	319:362	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	4	6	theme	enantiomers	777:787	arg1	order					768:772	elution order	760:772	elution order of enantiomers	760:787	For all liquid crystals, reversal of elution order of enantiomers was observed based on type of used cosolvent and/or its content in the mobile phase; for some of the liquid crystals a temperature-induced reversal was also observed.
33596334	0	7	theme	crystals	94:101	arg1	order					78:82	enantiomer elution order	59:82	enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate)	59:151	How mobile phase composition and column temperature affect enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate) as chiral selector.
33596334	1	8	theme	materials	354:362	arg1	set					312:314	a set	310:314	a set of chiral rod-like liquid crystalline materials	310:362	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	1	8	theme	materials	354:362	arg1	materials					354:362	chiral rod-like liquid crystalline materials	319:362	chiral rod-like liquid crystalline materials	319:362	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	6	9	theme	organic	1172:1178	arg1	solvents					1180:1187	organic solvents	1172:1187	organic solvents	1172:1187	Tested mobile phases comprised pure organic solvents and binary and tertiary mixtures of acetonitrile with organic solvents and/or water.
33596334	0	10	dep	amylose	106:112	arg1	3-chloro-5-methylphenylcarbamate					119:150	3-chloro-5-methylphenylcarbamate	119:150	3-chloro-5-methylphenylcarbamate	119:150	How mobile phase composition and column temperature affect enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate) as chiral selector.
33596334	0	10	dep	amylose	106:112	arg1	tris					114:117	tris	114:117	amylose tris(3-chloro-5-methylphenylcarbamate)	106:151	How mobile phase composition and column temperature affect enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate) as chiral selector.
33596334	5	11	theme	nonlinear	972:980	arg1	dependencies					982:993	Both linear and nonlinear dependencies	956:993	Both linear and nonlinear dependencies of natural logarithm of enantioselectivity on temperature	956:1051	Both linear and nonlinear dependencies of natural logarithm of enantioselectivity on temperature were found.
33596334	1	12	theme	enantiomer	266:275	arg1	order					285:289	enantiomer elution order	266:289	enantiomer elution order	266:289	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	0	13	theme	liquid	87:92	arg1	crystals					94:101	liquid crystals	87:101	liquid crystals	87:101	How mobile phase composition and column temperature affect enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate) as chiral selector.
33596334	4	14	from	content	845:851	arg1	phase					867:871	the mobile phase	856:871	the mobile phase	856:871	For all liquid crystals, reversal of elution order of enantiomers was observed based on type of used cosolvent and/or its content in the mobile phase; for some of the liquid crystals a temperature-induced reversal was also observed.
33596334	4	15	theme	mobile	860:865	arg1	phase					867:871	the mobile phase	856:871	the mobile phase	856:871	For all liquid crystals, reversal of elution order of enantiomers was observed based on type of used cosolvent and/or its content in the mobile phase; for some of the liquid crystals a temperature-induced reversal was also observed.
33596334	5	16	from	dependencies	982:993	arg1	temperature					1041:1051	temperature	1041:1051	temperature	1041:1051	Both linear and nonlinear dependencies of natural logarithm of enantioselectivity on temperature were found.
33596334	1	17	theme	elution	277:283	arg1	order					285:289	enantiomer elution order	266:289	enantiomer elution order	266:289	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	2	18	theme	rings	507:511	arg1	presence					468:475	presence	468:475	presence of chlorine	468:487	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	2	18	theme	rings	507:511	arg1	type					518:521	type	518:521	type of chiral center	518:538	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	2	18	theme	rings	507:511	arg1	number					490:495	number	490:495	number of phenyl rings	490:511	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	2	18	theme	rings	507:511	arg1	length					436:441	length	436:441	length of terminal alkyl chain	436:465	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	6	19	with	solvents	1109:1116	arg1	solvents					1180:1187	organic solvents	1172:1187	organic solvents	1172:1187	Tested mobile phases comprised pure organic solvents and binary and tertiary mixtures of acetonitrile with organic solvents and/or water.
33596334	6	19	with	solvents	1109:1116	arg1	water					1196:1200	water	1196:1200	water	1196:1200	Tested mobile phases comprised pure organic solvents and binary and tertiary mixtures of acetonitrile with organic solvents and/or water.
33596334	2	20	theme	chlorine	480:487	arg1	presence					468:475	presence	468:475	presence of chlorine	468:487	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	2	20	theme	chlorine	480:487	arg1	type					518:521	type	518:521	type of chiral center	518:538	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	2	20	theme	chlorine	480:487	arg1	number					490:495	number	490:495	number of phenyl rings	490:511	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	2	20	theme	chlorine	480:487	arg1	length					436:441	length	436:441	length of terminal alkyl chain	436:465	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	4	21	theme	order	768:772	arg1	reversal					748:755	reversal	748:755	reversal of elution order of enantiomers	748:787	For all liquid crystals, reversal of elution order of enantiomers was observed based on type of used cosolvent and/or its content in the mobile phase; for some of the liquid crystals a temperature-induced reversal was also observed.
33596334	1	22	theme	comprehensive	175:187	arg1	study					189:193	A comprehensive study	173:193	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order	173:289	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	0	23	theme	mobile	4:9	arg1	composition					17:27	mobile phase composition	4:27	mobile phase composition	4:27	How mobile phase composition and column temperature affect enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate) as chiral selector.
33596334	7	24	theme	phase	1233:1237	arg1	additives					1239:1247	acidic/basic mobile phase additives	1213:1247	acidic/basic mobile phase additives	1213:1247	Effect of acidic/basic mobile phase additives was also tested.
33596334	2	25	theme	phenyl	500:505	arg1	rings					507:511	phenyl rings	500:511	phenyl rings	500:511	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	6	26	theme	Tested	1065:1070	arg1	phases					1079:1084	Tested mobile phases	1065:1084	Tested mobile phases	1065:1084	Tested mobile phases comprised pure organic solvents and binary and tertiary mixtures of acetonitrile with organic solvents and/or water.
33596334	2	27	theme	alkyl	455:459	arg1	chain					461:465	terminal alkyl chain	446:465	terminal alkyl chain	446:465	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	4	28	theme	liquid	731:736	arg1	crystals					738:745	all liquid crystals	727:745	all liquid crystals	727:745	For all liquid crystals, reversal of elution order of enantiomers was observed based on type of used cosolvent and/or its content in the mobile phase; for some of the liquid crystals a temperature-induced reversal was also observed.
33596334	4	29	theme	elution	760:766	arg1	order					768:772	elution order	760:772	elution order of enantiomers	760:787	For all liquid crystals, reversal of elution order of enantiomers was observed based on type of used cosolvent and/or its content in the mobile phase; for some of the liquid crystals a temperature-induced reversal was also observed.
33596334	2	30	theme	terminal	446:453	arg1	chain					461:465	terminal alkyl chain	446:465	terminal alkyl chain	446:465	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	4	31	theme	liquid	890:895	arg1	crystals					897:904	the liquid crystals	886:904	the liquid crystals	886:904	For all liquid crystals, reversal of elution order of enantiomers was observed based on type of used cosolvent and/or its content in the mobile phase; for some of the liquid crystals a temperature-induced reversal was also observed.
33596334	5	32	theme	enantioselectivity	1019:1036	arg1	logarithm					1006:1014	natural logarithm	998:1014	natural logarithm of enantioselectivity	998:1036	Both linear and nonlinear dependencies of natural logarithm of enantioselectivity on temperature were found.
33596334	5	33	theme	natural	998:1004	arg1	logarithm					1006:1014	natural logarithm	998:1014	natural logarithm of enantioselectivity	998:1036	Both linear and nonlinear dependencies of natural logarithm of enantioselectivity on temperature were found.
33596334	8	34	theme	structure	1276:1284	arg1	Effect					1266:1271	Effect	1266:1271	Effect of structure of chiral selector	1266:1303	Effect of structure of chiral selector is briefly discussed.
33596334	0	35	theme	phase	11:15	arg1	composition					17:27	mobile phase composition	4:27	mobile phase composition	4:27	How mobile phase composition and column temperature affect enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate) as chiral selector.
33596334	2	36	theme	center	533:538	arg1	presence					468:475	presence	468:475	presence of chlorine	468:487	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	2	36	theme	center	533:538	arg1	type					518:521	type	518:521	type of chiral center	518:538	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	2	36	theme	center	533:538	arg1	number					490:495	number	490:495	number of phenyl rings	490:511	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	2	36	theme	center	533:538	arg1	length					436:441	length	436:441	length of terminal alkyl chain	436:465	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	6	37	theme	acetonitrile	1154:1165	arg1	mixtures					1142:1149	binary and tertiary mixtures	1122:1149	binary and tertiary mixtures	1122:1149	Tested mobile phases comprised pure organic solvents and binary and tertiary mixtures of acetonitrile with organic solvents and/or water.
33596334	6	37	theme	acetonitrile	1154:1165	arg1	solvents					1109:1116	pure organic solvents	1096:1116	pure organic solvents	1096:1116	Tested mobile phases comprised pure organic solvents and binary and tertiary mixtures of acetonitrile with organic solvents and/or water.
33596334	0	38	theme	column	33:38	arg1	temperature					40:50	column temperature	33:50	column temperature	33:50	How mobile phase composition and column temperature affect enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate) as chiral selector.
33596334	8	39	theme	selector	1296:1303	arg1	structure					1276:1284	structure	1276:1284	structure of chiral selector	1276:1303	Effect of structure of chiral selector is briefly discussed.
33596334	2	40	theme	chiral	526:531	arg1	center					533:538	chiral center	526:538	chiral center	526:538	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	0	41	from	order	78:82	arg1	amylose					106:112	amylose tris(3-chloro-5-methylphenylcarbamate)	106:151	amylose tris(3-chloro-5-methylphenylcarbamate)	106:151	How mobile phase composition and column temperature affect enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate) as chiral selector.
33596334	3	42	theme	organic	579:585	arg1	modes					606:610	polar organic and reversed-phase modes	573:610	polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase	573:720	Experiments were carried out in polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase.
33596334	8	43	theme	chiral	1289:1294	arg1	selector					1296:1303	chiral selector	1289:1303	chiral selector	1289:1303	Effect of structure of chiral selector is briefly discussed.
33596334	1	44	dep	phase	222:226	arg1	composition					228:238	composition	228:238	composition	228:238	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	5	45	theme	logarithm	1006:1014	arg1	dependencies					982:993	Both linear and nonlinear dependencies	956:993	Both linear and nonlinear dependencies of natural logarithm of enantioselectivity on temperature	956:1051	Both linear and nonlinear dependencies of natural logarithm of enantioselectivity on temperature were found.
33596334	1	46	theme	mobile	215:220	arg1	phase					222:226	mobile phase composition and column temperature	215:261	phase	222:226	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	6	47	with	mixtures	1142:1149	arg1	solvents					1180:1187	organic solvents	1172:1187	organic solvents	1172:1187	Tested mobile phases comprised pure organic solvents and binary and tertiary mixtures of acetonitrile with organic solvents and/or water.
33596334	6	47	with	mixtures	1142:1149	arg1	water					1196:1200	water	1196:1200	water	1196:1200	Tested mobile phases comprised pure organic solvents and binary and tertiary mixtures of acetonitrile with organic solvents and/or water.
33596334	0	48	theme	chiral	156:161	arg1	selector					163:170	chiral selector	156:170	chiral selector	156:170	How mobile phase composition and column temperature affect enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate) as chiral selector.
33596334	4	49	theme	used	819:822	arg1	cosolvent					824:832	used cosolvent	819:832	used cosolvent	819:832	For all liquid crystals, reversal of elution order of enantiomers was observed based on type of used cosolvent and/or its content in the mobile phase; for some of the liquid crystals a temperature-induced reversal was also observed.
33596334	6	50	theme	tertiary	1133:1140	arg1	mixtures					1142:1149	binary and tertiary mixtures	1122:1149	binary and tertiary mixtures	1122:1149	Tested mobile phases comprised pure organic solvents and binary and tertiary mixtures of acetonitrile with organic solvents and/or water.
33596334	4	51	theme	cosolvent	824:832	arg1	type					811:814	type	811:814	type of used cosolvent	811:832	For all liquid crystals, reversal of elution order of enantiomers was observed based on type of used cosolvent and/or its content in the mobile phase; for some of the liquid crystals a temperature-induced reversal was also observed.
33596334	3	52	theme	chiral	698:703	arg1	tris					626:629	amylose tris	618:629	amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel	618:689	Experiments were carried out in polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase.
33596334	3	52	theme	chiral	698:703	arg1	phase					716:720	the chiral stationary phase	694:720	the chiral stationary phase	694:720	Experiments were carried out in polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase.
33596334	3	53	theme	silica	680:685	arg1	gel					687:689	silica gel	680:689	silica gel	680:689	Experiments were carried out in polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase.
33596334	3	54	theme	polar	573:577	arg1	modes					606:610	polar organic and reversed-phase modes	573:610	polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase	573:720	Experiments were carried out in polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase.
33596334	7	55	theme	acidic/basic	1213:1224	arg1	additives					1239:1247	acidic/basic mobile phase additives	1213:1247	acidic/basic mobile phase additives	1213:1247	Effect of acidic/basic mobile phase additives was also tested.
33596334	7	56	theme	additives	1239:1247	arg1	Effect					1203:1208	Effect	1203:1208	Effect of acidic/basic mobile phase additives	1203:1247	Effect of acidic/basic mobile phase additives was also tested.
33596334	1	57	theme	chiral	319:324	arg1	materials					354:362	chiral rod-like liquid crystalline materials	319:362	chiral rod-like liquid crystalline materials	319:362	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	1	58	from	effects	204:210	arg1	order					285:289	enantiomer elution order	266:289	enantiomer elution order	266:289	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	6	59	theme	binary	1122:1127	arg1	mixtures					1142:1149	binary and tertiary mixtures	1122:1149	binary and tertiary mixtures	1122:1149	Tested mobile phases comprised pure organic solvents and binary and tertiary mixtures of acetonitrile with organic solvents and/or water.
33596334	1	60	theme	phase	222:226	arg1	effects					204:210	the effects	200:210	the effects of mobile phase composition and column temperature on enantiomer elution order	200:289	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	5	61	theme	linear	961:966	arg1	dependencies					982:993	Both linear and nonlinear dependencies	956:993	Both linear and nonlinear dependencies of natural logarithm of enantioselectivity on temperature	956:1051	Both linear and nonlinear dependencies of natural logarithm of enantioselectivity on temperature were found.
33596334	3	62	theme	amylose	618:624	arg1	3-chloro-5-methylphenylcarbamate					631:662	3-chloro-5-methylphenylcarbamate	631:662	3-chloro-5-methylphenylcarbamate	631:662	Experiments were carried out in polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase.
33596334	3	62	theme	amylose	618:624	arg1	tris					626:629	amylose tris	618:629	amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel	618:689	Experiments were carried out in polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase.
33596334	3	62	theme	amylose	618:624	arg1	phase					716:720	the chiral stationary phase	694:720	the chiral stationary phase	694:720	Experiments were carried out in polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase.
33596334	4	63	theme	temperature-induced	908:926	arg1	reversal					928:935	a temperature-induced reversal	906:935	a temperature-induced reversal	906:935	For all liquid crystals, reversal of elution order of enantiomers was observed based on type of used cosolvent and/or its content in the mobile phase; for some of the liquid crystals a temperature-induced reversal was also observed.
33596334	0	64	theme	elution	70:76	arg1	order					78:82	enantiomer elution order	59:82	enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate)	59:151	How mobile phase composition and column temperature affect enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate) as chiral selector.
33596334	6	65	theme	organic	1101:1107	arg1	solvents					1109:1116	pure organic solvents	1096:1116	pure organic solvents	1096:1116	Tested mobile phases comprised pure organic solvents and binary and tertiary mixtures of acetonitrile with organic solvents and/or water.
33596334	3	66	theme	reversed-phase	591:604	arg1	modes					606:610	polar organic and reversed-phase modes	573:610	polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase	573:720	Experiments were carried out in polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase.
33596334	6	67	theme	mobile	1072:1077	arg1	phases					1079:1084	Tested mobile phases	1065:1084	Tested mobile phases	1065:1084	Tested mobile phases comprised pure organic solvents and binary and tertiary mixtures of acetonitrile with organic solvents and/or water.
33596334	0	68	theme	enantiomer	59:68	arg1	order					78:82	enantiomer elution order	59:82	enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate)	59:151	How mobile phase composition and column temperature affect enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate) as chiral selector.
33596334	1	69	theme	rod-like	326:333	arg1	materials					354:362	chiral rod-like liquid crystalline materials	319:362	chiral rod-like liquid crystalline materials	319:362	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33596334	2	70	theme	chain	461:465	arg1	presence					468:475	presence	468:475	presence of chlorine	468:487	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	2	70	theme	chain	461:465	arg1	type					518:521	type	518:521	type of chiral center	518:538	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	2	70	theme	chain	461:465	arg1	number					490:495	number	490:495	number of phenyl rings	490:511	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	2	70	theme	chain	461:465	arg1	length					436:441	length	436:441	length of terminal alkyl chain	436:465	The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center.
33596334	1	71	theme	column	244:249	arg1	temperature					251:261	column temperature	244:261	column temperature	244:261	A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials.
33964341	5	0	theme	materials	773:781	arg1	behavior					740:747	rheological behavior	728:747	rheological behavior	728:747	In this study, various hydrogels were used to improve the mixing uniformity and rheological behavior of PEGDA-based printing materials.
33964341	5	0	theme	materials	773:781	arg1	uniformity					713:722	mixing uniformity	706:722	mixing uniformity	706:722	In this study, various hydrogels were used to improve the mixing uniformity and rheological behavior of PEGDA-based printing materials.
33964341	8	1	theme	minimal	1200:1206	arg1	time					1214:1217	the minimal layer time	1196:1217	the minimal layer time of the 3D samples	1196:1235	Although the storage modulus of the photocured material proportionally increased with curing time in the range of 20-80 s, the minimal layer time of the 3D samples remained at 65 s, ensuring interlayer adhesion.
33964341	8	2	theme	storage	1086:1092	arg1	modulus					1094:1100	the storage modulus	1082:1100	the storage modulus of the photocured material	1082:1127	Although the storage modulus of the photocured material proportionally increased with curing time in the range of 20-80 s, the minimal layer time of the 3D samples remained at 65 s, ensuring interlayer adhesion.
33964341	3	3	theme	used	445:448	arg1	polymer					463:469	the commonly used photocurable polymer	432:469	the commonly used photocurable polymer	432:469	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	3	3	theme	used	445:448	arg1	glycol					485:490	polyethylene glycol diacrylate	472:501	polyethylene glycol diacrylate (PEGDA)	472:509	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	11	4	theme	extrusion	1574:1582	arg1	printing					1584:1591	extrusion printing	1574:1591	extrusion printing with a photocurable material	1574:1620	Overall, this study demonstrates that extrusion printing with a photocurable material is an easy way to prepare customized oral preparations with complex internal structures and tunable properties.
33964341	11	4	theme	extrusion	1574:1582	arg1	way					1633:1635	an easy way	1625:1635	an easy way to prepare customized oral preparations with complex internal structures and tunable properties	1625:1731	Overall, this study demonstrates that extrusion printing with a photocurable material is an easy way to prepare customized oral preparations with complex internal structures and tunable properties.
33964341	0	5	theme	printing	110:117	arg1	material					119:126	photocurable printing material	97:126	photocurable printing material	97:126	Three-dimensional printing of gastro-floating tablets using polyethylene glycol diacrylate-based photocurable printing material.
33964341	11	6	theme	internal	1690:1697	arg1	structures					1699:1708	complex internal structures	1682:1708	complex internal structures	1682:1708	Overall, this study demonstrates that extrusion printing with a photocurable material is an easy way to prepare customized oral preparations with complex internal structures and tunable properties.
33964341	9	7	theme	infill	1324:1329	arg1	densities					1331:1339	different infill densities	1314:1339	different infill densities	1314:1339	Gastro-floating tablets with different infill densities were printed to illustrate the application of 3D extrusion printing in personalized medicine.
33964341	7	8	theme	printing	1014:1021	arg1	materials					1023:1031	printing materials	1014:1031	printing materials	1014:1031	Hydroxypropyl methylcellulose K100M was found to improve the shear thinning and self-supporting properties of printing materials, which were essential for printability.
33964341	3	9	theme	low	518:520	arg1	viscosity					522:530	a low viscosity	516:530	a low viscosity	516:530	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	7	10	theme	Hydroxypropyl	904:916	arg1	K100M					934:938	Hydroxypropyl methylcellulose K100M	904:938	Hydroxypropyl methylcellulose K100M	904:938	Hydroxypropyl methylcellulose K100M was found to improve the shear thinning and self-supporting properties of printing materials, which were essential for printability.
33964341	10	11	theme	infill	1506:1511	arg1	density					1513:1519	the infill density	1502:1519	the infill density of the models	1502:1533	The weight, crushing strength, and floating time were regulated by the infill density of the models.
33964341	7	12	theme	self-supporting	984:998	arg1	properties					1000:1009	the shear thinning and self-supporting properties	961:1009	the shear thinning and self-supporting properties of printing materials, which were essential for printability	961:1070	Hydroxypropyl methylcellulose K100M was found to improve the shear thinning and self-supporting properties of printing materials, which were essential for printability.
33964341	7	13	theme	materials	1023:1031	arg1	properties					1000:1009	the shear thinning and self-supporting properties	961:1009	the shear thinning and self-supporting properties of printing materials, which were essential for printability	961:1070	Hydroxypropyl methylcellulose K100M was found to improve the shear thinning and self-supporting properties of printing materials, which were essential for printability.
33964341	3	14	theme	long	547:550	arg1	time					565:568	a long crosslinking time	545:568	a long crosslinking time	545:568	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	7	15	theme	methylcellulose	918:932	arg1	K100M					934:938	Hydroxypropyl methylcellulose K100M	904:938	Hydroxypropyl methylcellulose K100M	904:938	Hydroxypropyl methylcellulose K100M was found to improve the shear thinning and self-supporting properties of printing materials, which were essential for printability.
33964341	5	16	theme	rheological	728:738	arg1	behavior					740:747	rheological behavior	728:747	rheological behavior	728:747	In this study, various hydrogels were used to improve the mixing uniformity and rheological behavior of PEGDA-based printing materials.
33964341	5	17	theme	various	663:669	arg1	hydrogels					671:679	various hydrogels	663:679	various hydrogels	663:679	In this study, various hydrogels were used to improve the mixing uniformity and rheological behavior of PEGDA-based printing materials.
33964341	10	18	theme	crushing	1447:1454	arg1	strength					1456:1463	crushing strength	1447:1463	crushing strength	1447:1463	The weight, crushing strength, and floating time were regulated by the infill density of the models.
33964341	3	19	theme	crosslinking	552:563	arg1	time					565:568	a long crosslinking time	545:568	a long crosslinking time	545:568	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	8	20	theme	20-80 s	1187:1193	arg1	range					1178:1182	the range	1174:1182	the range of 20-80 s	1174:1193	Although the storage modulus of the photocured material proportionally increased with curing time in the range of 20-80 s, the minimal layer time of the 3D samples remained at 65 s, ensuring interlayer adhesion.
33964341	11	21	theme	tunable	1714:1720	arg1	properties					1722:1731	tunable properties	1714:1731	tunable properties	1714:1731	Overall, this study demonstrates that extrusion printing with a photocurable material is an easy way to prepare customized oral preparations with complex internal structures and tunable properties.
33964341	8	22	theme	photocured	1109:1118	arg1	material					1120:1127	the photocured material	1105:1127	the photocured material	1105:1127	Although the storage modulus of the photocured material proportionally increased with curing time in the range of 20-80 s, the minimal layer time of the 3D samples remained at 65 s, ensuring interlayer adhesion.
33964341	2	23	dep	extrudate	394:402	arg1	the					390:392	the	390:392	the	390:392	This has been attributed to the operational aspect that can be performed at room temperature and the high mechanical strength of the extrudate and final product.
33964341	1	24	theme	application	217:227	arg1	prospects					229:237	good application prospects	212:237	good application prospects	212:237	Extruded three-dimensional (3D) printing based on photocurable materials has shown good application prospects in the medical field.
33964341	3	25	contain	has	512:514	arg1	polymer					463:469	the commonly used photocurable polymer	432:469	the commonly used photocurable polymer	432:469	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	3	25	contain	has	512:514	arg1	glycol					485:490	polyethylene glycol diacrylate	472:501	polyethylene glycol diacrylate (PEGDA)	472:509	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	3	25	contain	has	512:514	arg2	viscosity					522:530	a low viscosity	516:530	a low viscosity	516:530	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	11	26	theme	easy	1628:1631	arg1	way					1633:1635	an easy way	1625:1635	an easy way to prepare customized oral preparations with complex internal structures and tunable properties	1625:1731	Overall, this study demonstrates that extrusion printing with a photocurable material is an easy way to prepare customized oral preparations with complex internal structures and tunable properties.
33964341	11	26	theme	easy	1628:1631	arg1	printing					1584:1591	extrusion printing	1574:1591	extrusion printing with a photocurable material	1574:1620	Overall, this study demonstrates that extrusion printing with a photocurable material is an easy way to prepare customized oral preparations with complex internal structures and tunable properties.
33964341	6	27	theme	mechanical	806:815	arg1	strength					817:824	mechanical strength	806:824	mechanical strength	806:824	Printing accuracy and mechanical strength were evaluated to optimize print material composition and process parameters.
33964341	5	28	used	used	686:689	arg2	hydrogels					671:679	various hydrogels	663:679	various hydrogels	663:679	In this study, various hydrogels were used to improve the mixing uniformity and rheological behavior of PEGDA-based printing materials.
33964341	1	29	theme	good	212:215	arg1	prospects					229:237	good application prospects	212:237	good application prospects	212:237	Extruded three-dimensional (3D) printing based on photocurable materials has shown good application prospects in the medical field.
33964341	8	30	theme	samples	1229:1235	arg1	time					1214:1217	the minimal layer time	1196:1217	the minimal layer time of the 3D samples	1196:1235	Although the storage modulus of the photocured material proportionally increased with curing time in the range of 20-80 s, the minimal layer time of the 3D samples remained at 65 s, ensuring interlayer adhesion.
33964341	9	31	theme	3D	1387:1388	arg1	printing					1400:1407	3D extrusion printing	1387:1407	3D extrusion printing	1387:1407	Gastro-floating tablets with different infill densities were printed to illustrate the application of 3D extrusion printing in personalized medicine.
33964341	5	32	theme	PEGDA-based	752:762	arg1	materials					773:781	PEGDA-based printing materials	752:781	PEGDA-based printing materials	752:781	In this study, various hydrogels were used to improve the mixing uniformity and rheological behavior of PEGDA-based printing materials.
33964341	11	33	theme	complex	1682:1688	arg1	structures					1699:1708	complex internal structures	1682:1708	complex internal structures	1682:1708	Overall, this study demonstrates that extrusion printing with a photocurable material is an easy way to prepare customized oral preparations with complex internal structures and tunable properties.
33964341	2	34	theme	final	408:412	arg1	product					414:420	final product	408:420	final product	408:420	This has been attributed to the operational aspect that can be performed at room temperature and the high mechanical strength of the extrudate and final product.
33964341	0	35	theme	Three-dimensional	0:16	arg1	printing					18:25	Three-dimensional printing	0:25	Three-dimensional printing of gastro-floating tablets using polyethylene glycol	0:78	Three-dimensional printing of gastro-floating tablets using polyethylene glycol diacrylate-based photocurable printing material.
33964341	9	36	theme	extrusion	1390:1398	arg1	printing					1400:1407	3D extrusion printing	1387:1407	3D extrusion printing	1387:1407	Gastro-floating tablets with different infill densities were printed to illustrate the application of 3D extrusion printing in personalized medicine.
33964341	8	37	theme	material	1120:1127	arg1	modulus					1094:1100	the storage modulus	1082:1100	the storage modulus of the photocured material	1082:1127	Although the storage modulus of the photocured material proportionally increased with curing time in the range of 20-80 s, the minimal layer time of the 3D samples remained at 65 s, ensuring interlayer adhesion.
33964341	10	38	theme	floating	1470:1477	arg1	time					1479:1482	floating time	1470:1482	floating time	1470:1482	The weight, crushing strength, and floating time were regulated by the infill density of the models.
33964341	1	39	theme	Extruded	129:136	arg1	printing					161:168	Extruded three-dimensional (3D) printing	129:168	Extruded three-dimensional (3D) printing based on photocurable materials	129:200	Extruded three-dimensional (3D) printing based on photocurable materials has shown good application prospects in the medical field.
33964341	3	40	theme	photocurable	450:461	arg1	polymer					463:469	the commonly used photocurable polymer	432:469	the commonly used photocurable polymer	432:469	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	3	40	theme	photocurable	450:461	arg1	glycol					485:490	polyethylene glycol diacrylate	472:501	polyethylene glycol diacrylate (PEGDA)	472:509	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	0	41	theme	gastro-floating	30:44	arg1	tablets					46:52	gastro-floating tablets	30:52	gastro-floating tablets using polyethylene glycol	30:78	Three-dimensional printing of gastro-floating tablets using polyethylene glycol diacrylate-based photocurable printing material.
33964341	9	42	theme	printing	1400:1407	arg1	application					1372:1382	the application	1368:1382	the application of 3D extrusion printing in personalized medicine	1368:1432	Gastro-floating tablets with different infill densities were printed to illustrate the application of 3D extrusion printing in personalized medicine.
33964341	6	43	theme	Printing	784:791	arg1	accuracy					793:800	Printing accuracy	784:800	Printing accuracy	784:800	Printing accuracy and mechanical strength were evaluated to optimize print material composition and process parameters.
33964341	1	44	theme	three-dimensional	138:154	arg1	printing					161:168	Extruded three-dimensional (3D) printing	129:168	Extruded three-dimensional (3D) printing based on photocurable materials	129:200	Extruded three-dimensional (3D) printing based on photocurable materials has shown good application prospects in the medical field.
33964341	9	45	with	tablets	1301:1307	arg1	densities					1331:1339	different infill densities	1314:1339	different infill densities	1314:1339	Gastro-floating tablets with different infill densities were printed to illustrate the application of 3D extrusion printing in personalized medicine.
33964341	3	46	theme	diacrylate	492:501	arg1	polymer					463:469	the commonly used photocurable polymer	432:469	the commonly used photocurable polymer	432:469	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	3	46	theme	diacrylate	492:501	arg1	glycol					485:490	polyethylene glycol diacrylate	472:501	polyethylene glycol diacrylate (PEGDA)	472:509	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	3	46	theme	diacrylate	492:501	arg1	PEGDA					504:508	PEGDA	504:508	PEGDA	504:508	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	2	47	theme	room	337:340	arg1	temperature					342:352	room temperature	337:352	room temperature	337:352	This has been attributed to the operational aspect that can be performed at room temperature and the high mechanical strength of the extrudate and final product.
33964341	1	48	dep	three-dimensional	138:154	arg1	3D					157:158	3D	157:158	3D	157:158	Extruded three-dimensional (3D) printing based on photocurable materials has shown good application prospects in the medical field.
33964341	9	49	theme	personalized	1412:1423	arg1	medicine					1425:1432	personalized medicine	1412:1432	personalized medicine	1412:1432	Gastro-floating tablets with different infill densities were printed to illustrate the application of 3D extrusion printing in personalized medicine.
33964341	5	50	theme	mixing	706:711	arg1	uniformity					713:722	mixing uniformity	706:722	mixing uniformity	706:722	In this study, various hydrogels were used to improve the mixing uniformity and rheological behavior of PEGDA-based printing materials.
33964341	3	51	theme	polyethylene	472:483	arg1	polymer					463:469	the commonly used photocurable polymer	432:469	the commonly used photocurable polymer	432:469	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	3	51	theme	polyethylene	472:483	arg1	glycol					485:490	polyethylene glycol diacrylate	472:501	polyethylene glycol diacrylate (PEGDA)	472:509	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	3	51	theme	polyethylene	472:483	arg1	PEGDA					504:508	PEGDA	504:508	PEGDA	504:508	However, the commonly used photocurable polymer, polyethylene glycol diacrylate (PEGDA), has a low viscosity and exhibits a long crosslinking time.
33964341	1	52	theme	medical	246:252	arg1	field					254:258	the medical field	242:258	the medical field	242:258	Extruded three-dimensional (3D) printing based on photocurable materials has shown good application prospects in the medical field.
33964341	0	53	theme	tablets	46:52	arg1	printing					18:25	Three-dimensional printing	0:25	Three-dimensional printing of gastro-floating tablets using polyethylene glycol	0:78	Three-dimensional printing of gastro-floating tablets using polyethylene glycol diacrylate-based photocurable printing material.
33964341	11	54	with	printing	1584:1591	arg1	material					1613:1620	a photocurable material	1598:1620	a photocurable material	1598:1620	Overall, this study demonstrates that extrusion printing with a photocurable material is an easy way to prepare customized oral preparations with complex internal structures and tunable properties.
33964341	9	55	theme	Gastro-floating	1285:1299	arg1	tablets					1301:1307	Gastro-floating tablets	1285:1307	Gastro-floating tablets with different infill densities	1285:1339	Gastro-floating tablets with different infill densities were printed to illustrate the application of 3D extrusion printing in personalized medicine.
33964341	8	56	theme	interlayer	1264:1273	arg1	adhesion					1275:1282	interlayer adhesion	1264:1282	interlayer adhesion	1264:1282	Although the storage modulus of the photocured material proportionally increased with curing time in the range of 20-80 s, the minimal layer time of the 3D samples remained at 65 s, ensuring interlayer adhesion.
33964341	5	57	dep	uniformity	713:722	arg1	the					702:704	the	702:704	the	702:704	In this study, various hydrogels were used to improve the mixing uniformity and rheological behavior of PEGDA-based printing materials.
33964341	11	58	theme	customized	1648:1657	arg1	preparations					1664:1675	customized oral preparations	1648:1675	customized oral preparations	1648:1675	Overall, this study demonstrates that extrusion printing with a photocurable material is an easy way to prepare customized oral preparations with complex internal structures and tunable properties.
33964341	2	59	theme	mechanical	367:376	arg1	strength					378:385	the high mechanical strength	358:385	the high mechanical strength of the extrudate and final product	358:420	This has been attributed to the operational aspect that can be performed at room temperature and the high mechanical strength of the extrudate and final product.
33964341	0	60	theme	polyethylene	60:71	arg1	glycol					73:78	polyethylene glycol	60:78	polyethylene glycol	60:78	Three-dimensional printing of gastro-floating tablets using polyethylene glycol diacrylate-based photocurable printing material.
33964341	9	61	theme	different	1314:1322	arg1	densities					1331:1339	different infill densities	1314:1339	different infill densities	1314:1339	Gastro-floating tablets with different infill densities were printed to illustrate the application of 3D extrusion printing in personalized medicine.
33964341	2	62	theme	high	362:365	arg1	strength					378:385	the high mechanical strength	358:385	the high mechanical strength of the extrudate and final product	358:420	This has been attributed to the operational aspect that can be performed at room temperature and the high mechanical strength of the extrudate and final product.
33964341	7	63	theme	thinning	971:978	arg1	properties					1000:1009	the shear thinning and self-supporting properties	961:1009	the shear thinning and self-supporting properties of printing materials, which were essential for printability	961:1070	Hydroxypropyl methylcellulose K100M was found to improve the shear thinning and self-supporting properties of printing materials, which were essential for printability.
33964341	6	64	theme	material	859:866	arg1	composition					868:878	print material composition	853:878	print material composition	853:878	Printing accuracy and mechanical strength were evaluated to optimize print material composition and process parameters.
33964341	2	65	theme	operational	293:303	arg1	aspect					305:310	the operational aspect	289:310	the operational aspect that can be performed at room temperature and the high mechanical strength of the extrudate and final product	289:420	This has been attributed to the operational aspect that can be performed at room temperature and the high mechanical strength of the extrudate and final product.
33964341	11	66	theme	photocurable	1600:1611	arg1	material					1613:1620	a photocurable material	1598:1620	a photocurable material	1598:1620	Overall, this study demonstrates that extrusion printing with a photocurable material is an easy way to prepare customized oral preparations with complex internal structures and tunable properties.
33964341	6	67	theme	print	853:857	arg1	composition					868:878	print material composition	853:878	print material composition	853:878	Printing accuracy and mechanical strength were evaluated to optimize print material composition and process parameters.
33964341	8	68	theme	3D	1226:1227	arg1	samples					1229:1235	the 3D samples	1222:1235	the 3D samples	1222:1235	Although the storage modulus of the photocured material proportionally increased with curing time in the range of 20-80 s, the minimal layer time of the 3D samples remained at 65 s, ensuring interlayer adhesion.
33964341	10	69	theme	models	1528:1533	arg1	density					1513:1519	the infill density	1502:1519	the infill density of the models	1502:1533	The weight, crushing strength, and floating time were regulated by the infill density of the models.
33964341	0	70	theme	photocurable	97:108	arg1	material					119:126	photocurable printing material	97:126	photocurable printing material	97:126	Three-dimensional printing of gastro-floating tablets using polyethylene glycol diacrylate-based photocurable printing material.
33964341	4	71	theme	extrudate	637:645	arg1	printability					617:628	the printability	613:628	the printability of the extrudate	613:645	Therefore, additives are added to improve the printability of the extrudate.
33964341	2	72	theme	extrudate	394:402	arg1	strength					378:385	the high mechanical strength	358:385	the high mechanical strength of the extrudate and final product	358:420	This has been attributed to the operational aspect that can be performed at room temperature and the high mechanical strength of the extrudate and final product.
33964341	2	72	theme	extrudate	394:402	arg1	temperature					342:352	room temperature	337:352	room temperature	337:352	This has been attributed to the operational aspect that can be performed at room temperature and the high mechanical strength of the extrudate and final product.
33964341	2	73	theme	product	414:420	arg1	strength					378:385	the high mechanical strength	358:385	the high mechanical strength of the extrudate and final product	358:420	This has been attributed to the operational aspect that can be performed at room temperature and the high mechanical strength of the extrudate and final product.
33964341	2	73	theme	product	414:420	arg1	temperature					342:352	room temperature	337:352	room temperature	337:352	This has been attributed to the operational aspect that can be performed at room temperature and the high mechanical strength of the extrudate and final product.
33964341	5	74	theme	printing	764:771	arg1	materials					773:781	PEGDA-based printing materials	752:781	PEGDA-based printing materials	752:781	In this study, various hydrogels were used to improve the mixing uniformity and rheological behavior of PEGDA-based printing materials.
33964341	9	75	from	application	1372:1382	arg1	medicine					1425:1432	personalized medicine	1412:1432	personalized medicine	1412:1432	Gastro-floating tablets with different infill densities were printed to illustrate the application of 3D extrusion printing in personalized medicine.
33964341	11	76	theme	oral	1659:1662	arg1	preparations					1664:1675	customized oral preparations	1648:1675	customized oral preparations	1648:1675	Overall, this study demonstrates that extrusion printing with a photocurable material is an easy way to prepare customized oral preparations with complex internal structures and tunable properties.
33964341	1	77	theme	photocurable	179:190	arg1	materials					192:200	photocurable materials	179:200	photocurable materials	179:200	Extruded three-dimensional (3D) printing based on photocurable materials has shown good application prospects in the medical field.
33964341	8	78	theme	layer	1208:1212	arg1	time					1214:1217	the minimal layer time	1196:1217	the minimal layer time of the 3D samples	1196:1235	Although the storage modulus of the photocured material proportionally increased with curing time in the range of 20-80 s, the minimal layer time of the 3D samples remained at 65 s, ensuring interlayer adhesion.
33255049	7	0	theme	hydrophobic	1212:1222	arg1	nanocarriers					1224:1235	hydrophobic nanocarriers	1212:1235	hydrophobic nanocarriers with encapsulation efficiency (EE)	1212:1270	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	1	1	theme	diseases	167:174	arg1	treatment					146:154	treatment	146:154	treatment of chronic diseases	146:174	Drug delivery for treatment of chronic diseases relies on the effective delivery of payload materials into the target cells in a long-term release.
33255049	5	2	from	differences	939:949	arg1	morphology					960:969	their morphology	954:969	their morphology	954:969	IR spectroscopy and fluorescence microscopy analysis confirmed the presence of SF and CS within ALG-based microgels revealing marked differences in their morphology and physicochemical properties.
33255049	5	2	from	differences	939:949	arg1	properties					991:1000	physicochemical properties	975:1000	physicochemical properties	975:1000	IR spectroscopy and fluorescence microscopy analysis confirmed the presence of SF and CS within ALG-based microgels revealing marked differences in their morphology and physicochemical properties.
33255049	0	3	theme	hydrophobic	80:90	arg1	nanocarriers					114:125	hydrophobic and hydrophilic model nanocarriers	80:125	hydrophobic and hydrophilic model nanocarriers	80:125	Hybrid microgels produced via droplet microfluidics for sustainable delivery of hydrophobic and hydrophilic model nanocarriers.
33255049	9	4	theme	nanoencapsulated	1612:1627	arg1	systems					1629:1635	nanoencapsulated systems	1612:1635	nanoencapsulated systems for drug delivery	1612:1653	The results highlight the versatility and tunable properties of these biobased microgels, being a good strategy to be used as an efficient platform in using macro and nanoencapsulated systems for drug delivery.
33255049	6	5	theme	microgels	1075:1083	arg1	composition					1085:1095	microgels composition	1075:1095	microgels composition	1075:1095	The release profiles of model nanoparticles revealed to be dependent on microgels composition and physicochemical properties.
33255049	4	6	theme	latex	652:656	arg1	NPs					682:684	NPs	682:684	NPs	682:684	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	4	6	theme	latex	652:656	arg1	beads					658:662	polystyrene latex beads	640:662	polystyrene latex beads in pristine form (NPs)	640:685	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	4	6	theme	latex	652:656	arg1	nanoparticles					625:637	two model nanoparticles	615:637	two model nanoparticles	615:637	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	1	7	theme	long-term	257:265	arg1	release					267:273	a long-term release	255:273	a long-term release	255:273	Drug delivery for treatment of chronic diseases relies on the effective delivery of payload materials into the target cells in a long-term release.
33255049	0	8	theme	model	108:112	arg1	nanocarriers					114:125	hydrophobic and hydrophilic model nanocarriers	80:125	hydrophobic and hydrophilic model nanocarriers	80:125	Hybrid microgels produced via droplet microfluidics for sustainable delivery of hydrophobic and hydrophilic model nanocarriers.
33255049	7	9	with	nanocarriers	1224:1235	arg1	EE					1268:1269	EE	1268:1269	EE	1268:1269	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	7	9	with	nanocarriers	1224:1235	arg1	efficiency					1256:1265	encapsulation efficiency	1242:1265	encapsulation efficiency (EE)	1242:1270	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	3	10	theme	droplet	501:507	arg1	microfluidics					509:521	droplet microfluidics	501:521	droplet microfluidics	501:521	Hybrid microgels were produced with silk fibroin (SF) and chondroitin sulfate (CS), and alginate (ALG) by droplet microfluidics.
33255049	0	11	theme	hydrophilic	96:106	arg1	nanocarriers					114:125	hydrophobic and hydrophilic model nanocarriers	80:125	hydrophobic and hydrophilic model nanocarriers	80:125	Hybrid microgels produced via droplet microfluidics for sustainable delivery of hydrophobic and hydrophilic model nanocarriers.
33255049	4	12	theme	ALG/CS/SF	544:552	arg1	microgels					554:562	ALG/SF, ALG/CS, and ALG/CS/SF microgels	524:562	ALG/SF, ALG/CS, and ALG/CS/SF microgels	524:562	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	4	13	theme	pristine	667:674	arg1	form					676:679	pristine form	667:679	pristine form	667:679	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	9	14	theme	drug	1641:1644	arg1	delivery					1646:1653	drug delivery	1641:1653	drug delivery	1641:1653	The results highlight the versatility and tunable properties of these biobased microgels, being a good strategy to be used as an efficient platform in using macro and nanoencapsulated systems for drug delivery.
33255049	7	15	theme	better	1297:1302	arg1	profile					1316:1322	a better sustainable profile	1295:1322	a better sustainable profile release than nonhybrid ALG microgels	1295:1359	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	4	16	theme	serum	714:718	arg1	NPs-BSA					729:735	NPs-BSA	729:735	NPs-BSA	729:735	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	4	16	theme	serum	714:718	arg1	albumin					720:726	bovine serum albumin	707:726	bovine serum albumin (NPs-BSA)	707:736	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	1	17	theme	effective	190:198	arg1	delivery					200:207	the effective delivery	186:207	the effective delivery of payload materials into the target cells in a long-term release	186:273	Drug delivery for treatment of chronic diseases relies on the effective delivery of payload materials into the target cells in a long-term release.
33255049	0	18	theme	nanocarriers	114:125	arg1	delivery					68:75	sustainable delivery	56:75	sustainable delivery of hydrophobic and hydrophilic model nanocarriers	56:125	Hybrid microgels produced via droplet microfluidics for sustainable delivery of hydrophobic and hydrophilic model nanocarriers.
33255049	4	19	theme	hydrophilic	766:776	arg1	nanocarriers					778:789	hydrophobic and hydrophilic nanocarriers	750:789	hydrophobic and hydrophilic nanocarriers	750:789	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	4	20	from	NPs	691:693	arg1	form					676:679	pristine form	667:679	pristine form	667:679	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	3	21	theme	Hybrid	395:400	arg1	microgels					402:410	Hybrid microgels	395:410	Hybrid microgels	395:410	Hybrid microgels were produced with silk fibroin (SF) and chondroitin sulfate (CS), and alginate (ALG) by droplet microfluidics.
33255049	5	22	theme	IR	806:807	arg1	spectroscopy					809:820	IR spectroscopy	806:820	IR spectroscopy	806:820	IR spectroscopy and fluorescence microscopy analysis confirmed the presence of SF and CS within ALG-based microgels revealing marked differences in their morphology and physicochemical properties.
33255049	7	23	theme	hybrid	1165:1170	arg1	microgels					1172:1180	SF ternary hybrid microgels	1154:1180	SF ternary hybrid microgels	1154:1180	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	7	24	theme	nanocarriers	1224:1235	arg1	entrapment					1198:1207	the entrapment	1194:1207	the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98%	1194:1285	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	7	25	dep	98	1283:1284	arg1	to					1280:1281	to	1280:1281	to	1280:1281	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	9	26	theme	good	1543:1546	arg1	strategy					1548:1555	a good strategy	1541:1555	a good strategy to be used as an efficient platform in using macro and nanoencapsulated systems for drug delivery	1541:1653	The results highlight the versatility and tunable properties of these biobased microgels, being a good strategy to be used as an efficient platform in using macro and nanoencapsulated systems for drug delivery.
33255049	9	27	theme	efficient	1574:1582	arg1	platform					1584:1591	an efficient platform	1571:1591	an efficient platform in using macro and nanoencapsulated systems for drug delivery	1571:1653	The results highlight the versatility and tunable properties of these biobased microgels, being a good strategy to be used as an efficient platform in using macro and nanoencapsulated systems for drug delivery.
33255049	3	28	theme	silk	431:434	arg1	SF					445:446	SF	445:446	SF	445:446	Hybrid microgels were produced with silk fibroin (SF) and chondroitin sulfate (CS), and alginate (ALG) by droplet microfluidics.
33255049	3	28	theme	silk	431:434	arg1	fibroin					436:442	silk fibroin	431:442	silk fibroin (SF)	431:447	Hybrid microgels were produced with silk fibroin (SF) and chondroitin sulfate (CS), and alginate (ALG) by droplet microfluidics.
33255049	0	29	theme	Hybrid	0:5	arg1	microgels					7:15	Hybrid microgels	0:15	Hybrid microgels	0:15	Hybrid microgels produced via droplet microfluidics for sustainable delivery of hydrophobic and hydrophilic model nanocarriers.
33255049	4	30	theme	ALG/SF	524:529	arg1	microgels					554:562	ALG/SF, ALG/CS, and ALG/CS/SF microgels	524:562	ALG/SF, ALG/CS, and ALG/CS/SF microgels	524:562	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	5	31	theme	CS	892:893	arg1	presence					873:880	the presence	869:880	the presence of SF and CS	869:893	IR spectroscopy and fluorescence microscopy analysis confirmed the presence of SF and CS within ALG-based microgels revealing marked differences in their morphology and physicochemical properties.
33255049	9	32	dep	versatility	1471:1481	arg1	the					1467:1469	the	1467:1469	the	1467:1469	The results highlight the versatility and tunable properties of these biobased microgels, being a good strategy to be used as an efficient platform in using macro and nanoencapsulated systems for drug delivery.
33255049	2	33	theme	drug	380:383	arg1	delivery					385:392	drug delivery	380:392	drug delivery	380:392	In this context, the present study investigated hybrid microgels as platforms to carry nanoparticles to drug delivery.
33255049	7	34	theme	SF	1154:1155	arg1	microgels					1172:1180	SF ternary hybrid microgels	1154:1180	SF ternary hybrid microgels	1154:1180	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	5	35	theme	SF	885:886	arg1	presence					873:880	the presence	869:880	the presence of SF and CS	869:893	IR spectroscopy and fluorescence microscopy analysis confirmed the presence of SF and CS within ALG-based microgels revealing marked differences in their morphology and physicochemical properties.
33255049	2	36	theme	present	297:303	arg1	study					305:309	the present study	293:309	the present study	293:309	In this context, the present study investigated hybrid microgels as platforms to carry nanoparticles to drug delivery.
33255049	3	37	theme	chondroitin	453:463	arg1	CS					474:475	CS	474:475	CS	474:475	Hybrid microgels were produced with silk fibroin (SF) and chondroitin sulfate (CS), and alginate (ALG) by droplet microfluidics.
33255049	3	37	theme	chondroitin	453:463	arg1	sulfate					465:471	chondroitin sulfate	453:471	chondroitin sulfate (CS)	453:476	Hybrid microgels were produced with silk fibroin (SF) and chondroitin sulfate (CS), and alginate (ALG) by droplet microfluidics.
33255049	7	38	theme	ternary	1157:1163	arg1	microgels					1172:1180	SF ternary hybrid microgels	1154:1180	SF ternary hybrid microgels	1154:1180	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	4	39	theme	ALG/CS	532:537	arg1	microgels					554:562	ALG/SF, ALG/CS, and ALG/CS/SF microgels	524:562	ALG/SF, ALG/CS, and ALG/CS/SF microgels	524:562	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	5	40	theme	marked	932:937	arg1	differences					939:949	marked differences	932:949	marked differences in their morphology and physicochemical properties	932:1000	IR spectroscopy and fluorescence microscopy analysis confirmed the presence of SF and CS within ALG-based microgels revealing marked differences in their morphology and physicochemical properties.
33255049	5	41	theme	ALG-based	902:910	arg1	microgels					912:920	ALG-based microgels	902:920	ALG-based microgels revealing marked differences in their morphology and physicochemical properties	902:1000	IR spectroscopy and fluorescence microscopy analysis confirmed the presence of SF and CS within ALG-based microgels revealing marked differences in their morphology and physicochemical properties.
33255049	9	42	theme	biobased	1515:1522	arg1	microgels					1524:1532	these biobased microgels	1509:1532	these biobased microgels	1509:1532	The results highlight the versatility and tunable properties of these biobased microgels, being a good strategy to be used as an efficient platform in using macro and nanoencapsulated systems for drug delivery.
33255049	1	43	theme	payload	212:218	arg1	materials					220:228	payload materials	212:228	payload materials	212:228	Drug delivery for treatment of chronic diseases relies on the effective delivery of payload materials into the target cells in a long-term release.
33255049	5	44	theme	physicochemical	975:989	arg1	properties					991:1000	physicochemical properties	975:1000	physicochemical properties	975:1000	IR spectroscopy and fluorescence microscopy analysis confirmed the presence of SF and CS within ALG-based microgels revealing marked differences in their morphology and physicochemical properties.
33255049	4	45	theme	model	619:623	arg1	beads					658:662	polystyrene latex beads	640:662	polystyrene latex beads in pristine form (NPs)	640:685	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	4	45	theme	model	619:623	arg1	NPs					691:693	NPs	691:693	NPs	691:693	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	4	45	theme	model	619:623	arg1	nanoparticles					625:637	two model nanoparticles	615:637	two model nanoparticles	615:637	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	1	46	theme	materials	220:228	arg1	delivery					200:207	the effective delivery	186:207	the effective delivery of payload materials into the target cells in a long-term release	186:273	Drug delivery for treatment of chronic diseases relies on the effective delivery of payload materials into the target cells in a long-term release.
33255049	0	47	theme	droplet	30:36	arg1	microfluidics					38:50	droplet microfluidics	30:50	droplet microfluidics for sustainable delivery of hydrophobic and hydrophilic model nanocarriers	30:125	Hybrid microgels produced via droplet microfluidics for sustainable delivery of hydrophobic and hydrophilic model nanocarriers.
33255049	8	48	theme	release	1436:1442	arg1	carriage					1387:1394	the carriage	1383:1394	the carriage of NPs-BSA (EE = 85%) and their profile release	1383:1442	Besides, CS improved the carriage of NPs-BSA (EE = 85%) and their profile release.
33255049	7	49	from	%	1285:1285	arg1	entrapment					1198:1207	the entrapment	1194:1207	the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98%	1194:1285	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	6	50	theme	release	1007:1013	arg1	dependent					1062:1070	dependent	1062:1070	dependent	1062:1070	The release profiles of model nanoparticles revealed to be dependent on microgels composition and physicochemical properties.
33255049	6	50	theme	release	1007:1013	arg1	profiles					1015:1022	The release profiles	1003:1022	The release profiles of model nanoparticles	1003:1045	The release profiles of model nanoparticles revealed to be dependent on microgels composition and physicochemical properties.
33255049	0	51	theme	sustainable	56:66	arg1	delivery					68:75	sustainable delivery	56:75	sustainable delivery of hydrophobic and hydrophilic model nanocarriers	56:125	Hybrid microgels produced via droplet microfluidics for sustainable delivery of hydrophobic and hydrophilic model nanocarriers.
33255049	5	52	theme	fluorescence	826:837	arg1	microscopy					839:848	fluorescence microscopy	826:848	fluorescence microscopy analysis	826:857	IR spectroscopy and fluorescence microscopy analysis confirmed the presence of SF and CS within ALG-based microgels revealing marked differences in their morphology and physicochemical properties.
33255049	1	53	from	cells	246:250	arg1	release					267:273	a long-term release	255:273	a long-term release	255:273	Drug delivery for treatment of chronic diseases relies on the effective delivery of payload materials into the target cells in a long-term release.
33255049	8	54	theme	profile	1428:1434	arg1	release					1436:1442	their profile release	1422:1442	their profile release	1422:1442	Besides, CS improved the carriage of NPs-BSA (EE = 85%) and their profile release.
33255049	8	55	theme	NPs-BSA	1399:1405	arg1	carriage					1387:1394	the carriage	1383:1394	the carriage of NPs-BSA (EE = 85%) and their profile release	1383:1442	Besides, CS improved the carriage of NPs-BSA (EE = 85%) and their profile release.
33255049	1	56	theme	Drug	128:131	arg1	delivery					133:140	Drug delivery	128:140	Drug delivery for treatment of chronic diseases	128:174	Drug delivery for treatment of chronic diseases relies on the effective delivery of payload materials into the target cells in a long-term release.
33255049	9	57	theme	tunable	1487:1493	arg1	properties					1495:1504	tunable properties	1487:1504	tunable properties	1487:1504	The results highlight the versatility and tunable properties of these biobased microgels, being a good strategy to be used as an efficient platform in using macro and nanoencapsulated systems for drug delivery.
33255049	7	58	theme	profile	1316:1322	arg1	release					1324:1330	a better sustainable profile release	1295:1330	a better sustainable profile release than nonhybrid ALG microgels	1295:1359	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	9	59	theme	microgels	1524:1532	arg1	versatility					1471:1481	versatility	1471:1481	versatility	1471:1481	The results highlight the versatility and tunable properties of these biobased microgels, being a good strategy to be used as an efficient platform in using macro and nanoencapsulated systems for drug delivery.
33255049	9	59	theme	microgels	1524:1532	arg1	properties					1495:1504	tunable properties	1487:1504	tunable properties	1487:1504	The results highlight the versatility and tunable properties of these biobased microgels, being a good strategy to be used as an efficient platform in using macro and nanoencapsulated systems for drug delivery.
33255049	4	60	theme	hydrophobic	750:760	arg1	nanocarriers					778:789	hydrophobic and hydrophilic nanocarriers	750:789	hydrophobic and hydrophilic nanocarriers	750:789	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	6	61	theme	physicochemical	1101:1115	arg1	properties					1117:1126	physicochemical properties	1101:1126	physicochemical properties	1101:1126	The release profiles of model nanoparticles revealed to be dependent on microgels composition and physicochemical properties.
33255049	4	62	theme	bovine	707:712	arg1	NPs-BSA					729:735	NPs-BSA	729:735	NPs-BSA	729:735	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	4	62	theme	bovine	707:712	arg1	albumin					720:726	bovine serum albumin	707:726	bovine serum albumin (NPs-BSA)	707:736	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	6	63	theme	nanoparticles	1033:1045	arg1	dependent					1062:1070	dependent	1062:1070	dependent	1062:1070	The release profiles of model nanoparticles revealed to be dependent on microgels composition and physicochemical properties.
33255049	6	63	theme	nanoparticles	1033:1045	arg1	profiles					1015:1022	The release profiles	1003:1022	The release profiles of model nanoparticles	1003:1045	The release profiles of model nanoparticles revealed to be dependent on microgels composition and physicochemical properties.
33255049	2	64	theme	hybrid	324:329	arg1	platforms					344:352	platforms	344:352	platforms	344:352	In this context, the present study investigated hybrid microgels as platforms to carry nanoparticles to drug delivery.
33255049	2	64	theme	hybrid	324:329	arg1	microgels					331:339	hybrid microgels	324:339	hybrid microgels	324:339	In this context, the present study investigated hybrid microgels as platforms to carry nanoparticles to drug delivery.
33255049	7	65	theme	sustainable	1304:1314	arg1	profile					1316:1322	a better sustainable profile	1295:1322	a better sustainable profile release than nonhybrid ALG microgels	1295:1359	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	1	66	theme	target	239:244	arg1	cells					246:250	the target cells	235:250	the target cells in a long-term release	235:273	Drug delivery for treatment of chronic diseases relies on the effective delivery of payload materials into the target cells in a long-term release.
33255049	5	67	theme	microscopy	839:848	arg1	analysis					850:857	fluorescence microscopy analysis	826:857	fluorescence microscopy analysis	826:857	IR spectroscopy and fluorescence microscopy analysis confirmed the presence of SF and CS within ALG-based microgels revealing marked differences in their morphology and physicochemical properties.
33255049	7	68	theme	nonhybrid	1337:1345	arg1	microgels					1351:1359	nonhybrid ALG microgels	1337:1359	nonhybrid ALG microgels	1337:1359	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	6	69	theme	model	1027:1031	arg1	nanoparticles					1033:1045	model nanoparticles	1027:1045	model nanoparticles	1027:1045	The release profiles of model nanoparticles revealed to be dependent on microgels composition and physicochemical properties.
33255049	4	70	theme	polystyrene	640:650	arg1	NPs					682:684	NPs	682:684	NPs	682:684	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	4	70	theme	polystyrene	640:650	arg1	beads					658:662	polystyrene latex beads	640:662	polystyrene latex beads in pristine form (NPs)	640:685	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	4	70	theme	polystyrene	640:650	arg1	nanoparticles					625:637	two model nanoparticles	615:637	two model nanoparticles	615:637	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
33255049	7	71	theme	encapsulation	1242:1254	arg1	EE					1268:1269	EE	1268:1269	EE	1268:1269	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	7	71	theme	encapsulation	1242:1254	arg1	efficiency					1256:1265	encapsulation efficiency	1242:1265	encapsulation efficiency (EE)	1242:1270	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	7	72	theme	ALG	1347:1349	arg1	microgels					1351:1359	nonhybrid ALG microgels	1337:1359	nonhybrid ALG microgels	1337:1359	These findings show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALG microgels.
33255049	1	73	theme	chronic	159:165	arg1	diseases					167:174	chronic diseases	159:174	chronic diseases	159:174	Drug delivery for treatment of chronic diseases relies on the effective delivery of payload materials into the target cells in a long-term release.
33255049	4	74	from	beads	658:662	arg1	form					676:679	pristine form	667:679	pristine form	667:679	ALG/SF, ALG/CS, and ALG/CS/SF microgels, ranging from 70-90 μm, were tested to encapsulate two model nanoparticles, polystyrene latex beads in pristine form (NPs) and NPs coated with bovine serum albumin (NPs-BSA) to simulate hydrophobic and hydrophilic nanocarriers, respectively.
34058205	0	0	theme	composites	92:101	arg1	mineralization					32:45	Gas assisted in situ biomimetic mineralization	0:45	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial	0:114	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial.
34058205	5	1	from	distribution	820:831	arg1	nanofibers					870:879	the cellulose nanofibers	856:879	the cellulose nanofibers	856:879	The uniform distribution of embedded objects on the cellulose nanofibers between internal and external was achieved.
34058205	1	2	theme	desired	174:180	arg1	need					182:185	desired need	174:185	desired need	174:185	Biomineralization inspired process to produce polymer of desired need is a promising approach in the field of research.
34058205	4	3	theme	calcium	734:740	arg1	carbonate					742:750	calcium carbonate	734:750	calcium carbonate	734:750	During the preparation of nanocomposites, the calcium ions embedded on the cellulose fibrils were served as the nucleation center and calcium carbonate was deposited into BC network in the assistance of CO2.
34058205	0	4	theme	bio	88:90	arg1	composites					92:101	bacterial cellulose/calcium carbonate bio composites	50:101	bacterial cellulose/calcium carbonate bio composites	50:101	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial.
34058205	1	5	theme	need	182:185	arg1	polymer					163:169	polymer	163:169	polymer of desired need	163:185	Biomineralization inspired process to produce polymer of desired need is a promising approach in the field of research.
34058205	2	6	theme	BC	283:284	arg1	nanocomposites					293:306	the bacterial cellulose (BC) based nanocomposites	258:306	the bacterial cellulose (BC) based nanocomposites with a 3D network	258:324	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	6	7	theme	inorganic	959:967	arg1	growth					969:974	inorganic growth	959:974	inorganic growth	959:974	The exploitation of organisms for inorganic growth, shape and self-assembling explores new opportunities to the design of original nanostructures.
34058205	3	8	theme	Scanning	521:528	arg1	Microscopy					539:548	Scanning Electron Microscopy	521:548	Scanning Electron Microscopy (SEM)	521:554	The BC based composites were characterized by employing with Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM).
34058205	3	8	theme	Scanning	521:528	arg1	SEM					551:553	SEM	551:553	SEM	551:553	The BC based composites were characterized by employing with Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM).
34058205	0	9	theme	Gas	0:2	arg1	mineralization					32:45	Gas assisted in situ biomimetic mineralization	0:45	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial	0:114	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial.
34058205	2	10	with	nanocomposites	293:306	arg1	network					318:324	a 3D network	313:324	a 3D network	313:324	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	4	11	theme	cellulose	675:683	arg1	fibrils					685:691	the cellulose fibrils	671:691	the cellulose fibrils	671:691	During the preparation of nanocomposites, the calcium ions embedded on the cellulose fibrils were served as the nucleation center and calcium carbonate was deposited into BC network in the assistance of CO2.
34058205	4	12	theme	CO2	803:805	arg1	assistance					789:798	the assistance	785:798	the assistance of CO2	785:805	During the preparation of nanocomposites, the calcium ions embedded on the cellulose fibrils were served as the nucleation center and calcium carbonate was deposited into BC network in the assistance of CO2.
34058205	6	13	theme	nanostructures	1056:1069	arg1	design					1037:1042	the design	1033:1042	the design of original nanostructures	1033:1069	The exploitation of organisms for inorganic growth, shape and self-assembling explores new opportunities to the design of original nanostructures.
34058205	2	14	theme	cellulose	272:280	arg1	nanocomposites					293:306	the bacterial cellulose (BC) based nanocomposites	258:306	the bacterial cellulose (BC) based nanocomposites with a 3D network	258:324	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	4	15	theme	nanocomposites	626:639	arg1	preparation					611:621	the preparation	607:621	the preparation of nanocomposites	607:639	During the preparation of nanocomposites, the calcium ions embedded on the cellulose fibrils were served as the nucleation center and calcium carbonate was deposited into BC network in the assistance of CO2.
34058205	5	16	theme	cellulose	860:868	arg1	nanofibers					870:879	the cellulose nanofibers	856:879	the cellulose nanofibers	856:879	The uniform distribution of embedded objects on the cellulose nanofibers between internal and external was achieved.
34058205	1	17	dep	process	144:150	arg1	produce					155:161	produce	155:161	to produce polymer of desired need	152:185	Biomineralization inspired process to produce polymer of desired need is a promising approach in the field of research.
34058205	6	18	theme	original	1047:1054	arg1	nanostructures					1056:1069	original nanostructures	1047:1069	original nanostructures	1047:1069	The exploitation of organisms for inorganic growth, shape and self-assembling explores new opportunities to the design of original nanostructures.
34058205	0	19	theme	assisted	4:11	arg1	mineralization					32:45	Gas assisted in situ biomimetic mineralization	0:45	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial	0:114	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial.
34058205	4	20	theme	nucleation	712:721	arg1	center					723:728	the nucleation center	708:728	the nucleation center	708:728	During the preparation of nanocomposites, the calcium ions embedded on the cellulose fibrils were served as the nucleation center and calcium carbonate was deposited into BC network in the assistance of CO2.
34058205	1	21	theme	promising	192:200	arg1	approach					202:209	a promising approach	190:209	a promising approach in the field of research	190:234	Biomineralization inspired process to produce polymer of desired need is a promising approach in the field of research.
34058205	1	21	theme	promising	192:200	arg1	process					144:150	Biomineralization inspired process	117:150	Biomineralization inspired process to produce polymer of desired need	117:185	Biomineralization inspired process to produce polymer of desired need is a promising approach in the field of research.
34058205	2	22	theme	calcium	419:425	arg1	metabolites					406:416	primary metabolites	398:416	primary metabolites (calcium gluconate)	398:436	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	2	22	theme	calcium	419:425	arg1	gluconate					427:435	calcium gluconate	419:435	calcium gluconate	419:435	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	6	23	theme	organisms	945:953	arg1	exploitation					929:940	The exploitation	925:940	The exploitation of organisms for inorganic growth, shape and self-assembling	925:1001	The exploitation of organisms for inorganic growth, shape and self-assembling explores new opportunities to the design of original nanostructures.
34058205	5	24	theme	uniform	812:818	arg1	distribution					820:831	The uniform distribution	808:831	The uniform distribution of embedded objects on the cellulose nanofibers between internal and external	808:909	The uniform distribution of embedded objects on the cellulose nanofibers between internal and external was achieved.
34058205	5	25	theme	embedded	836:843	arg1	objects					845:851	embedded objects	836:851	embedded objects	836:851	The uniform distribution of embedded objects on the cellulose nanofibers between internal and external was achieved.
34058205	2	26	theme	based	287:291	arg1	nanocomposites					293:306	the bacterial cellulose (BC) based nanocomposites	258:306	the bacterial cellulose (BC) based nanocomposites with a 3D network	258:324	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	2	27	theme	primary	398:404	arg1	metabolites					406:416	primary metabolites	398:416	primary metabolites (calcium gluconate)	398:436	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	2	27	theme	primary	398:404	arg1	gluconate					427:435	calcium gluconate	419:435	calcium gluconate	419:435	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	0	28	theme	in	13:14	arg1	mineralization					32:45	Gas assisted in situ biomimetic mineralization	0:45	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial	0:114	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial.
34058205	4	29	dep	ions	654:657	arg1	embedded					659:666	embedded	659:666	embedded	659:666	During the preparation of nanocomposites, the calcium ions embedded on the cellulose fibrils were served as the nucleation center and calcium carbonate was deposited into BC network in the assistance of CO2.
34058205	1	30	theme	Biomineralization	117:133	arg1	approach					202:209	a promising approach	190:209	a promising approach in the field of research	190:234	Biomineralization inspired process to produce polymer of desired need is a promising approach in the field of research.
34058205	1	30	theme	Biomineralization	117:133	arg1	process					144:150	Biomineralization inspired process	117:150	Biomineralization inspired process to produce polymer of desired need	117:185	Biomineralization inspired process to produce polymer of desired need is a promising approach in the field of research.
34058205	5	31	theme	objects	845:851	arg1	distribution					820:831	The uniform distribution	808:831	The uniform distribution of embedded objects on the cellulose nanofibers between internal and external	808:909	The uniform distribution of embedded objects on the cellulose nanofibers between internal and external was achieved.
34058205	2	32	theme	carbon	445:450	arg1	salt					390:393	the calcium salt	378:393	the calcium salt of primary metabolites (calcium gluconate)	378:436	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	2	32	theme	carbon	445:450	arg1	source					452:457	the carbon source	441:457	the carbon source	441:457	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	3	33	theme	Transmission	560:571	arg1	TEM					594:596	TEM	594:596	TEM	594:596	The BC based composites were characterized by employing with Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM).
34058205	3	33	theme	Transmission	560:571	arg1	Microscopy					582:591	Transmission Electron Microscopy	560:591	Transmission Electron Microscopy (TEM)	560:597	The BC based composites were characterized by employing with Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM).
34058205	0	34	theme	biomimetic	21:30	arg1	mineralization					32:45	Gas assisted in situ biomimetic mineralization	0:45	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial	0:114	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial.
34058205	3	35	theme	Electron	573:580	arg1	TEM					594:596	TEM	594:596	TEM	594:596	The BC based composites were characterized by employing with Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM).
34058205	3	35	theme	Electron	573:580	arg1	Microscopy					582:591	Transmission Electron Microscopy	560:591	Transmission Electron Microscopy (TEM)	560:597	The BC based composites were characterized by employing with Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM).
34058205	2	36	theme	calcium	382:388	arg1	salt					390:393	the calcium salt	378:393	the calcium salt of primary metabolites (calcium gluconate)	378:436	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	2	36	theme	calcium	382:388	arg1	source					452:457	the carbon source	441:457	the carbon source	441:457	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	0	37	theme	bacterial	50:58	arg1	composites					92:101	bacterial cellulose/calcium carbonate bio composites	50:101	bacterial cellulose/calcium carbonate bio composites	50:101	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial.
34058205	3	38	theme	based	467:471	arg1	composites					473:482	The BC based composites	460:482	The BC based composites	460:482	The BC based composites were characterized by employing with Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM).
34058205	1	39	theme	inspired	135:142	arg1	approach					202:209	a promising approach	190:209	a promising approach in the field of research	190:234	Biomineralization inspired process to produce polymer of desired need is a promising approach in the field of research.
34058205	1	39	theme	inspired	135:142	arg1	process					144:150	Biomineralization inspired process	117:150	Biomineralization inspired process to produce polymer of desired need	117:185	Biomineralization inspired process to produce polymer of desired need is a promising approach in the field of research.
34058205	3	40	theme	BC	464:465	arg1	composites					473:482	The BC based composites	460:482	The BC based composites	460:482	The BC based composites were characterized by employing with Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM).
34058205	2	41	theme	present	244:250	arg1	work					252:255	the present work	240:255	the present work	240:255	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	2	42	theme	3D	315:316	arg1	network					318:324	a 3D network	313:324	a 3D network	313:324	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	3	43	theme	Electron	530:537	arg1	Microscopy					539:548	Scanning Electron Microscopy	521:548	Scanning Electron Microscopy (SEM)	521:554	The BC based composites were characterized by employing with Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM).
34058205	3	43	theme	Electron	530:537	arg1	SEM					551:553	SEM	551:553	SEM	551:553	The BC based composites were characterized by employing with Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM).
34058205	1	44	theme	research	227:234	arg1	field					218:222	the field	214:222	the field of research	214:234	Biomineralization inspired process to produce polymer of desired need is a promising approach in the field of research.
34058205	2	45	theme	bacterial	262:270	arg1	nanocomposites					293:306	the bacterial cellulose (BC) based nanocomposites	258:306	the bacterial cellulose (BC) based nanocomposites with a 3D network	258:324	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	0	46	dep	in	13:14	arg1	situ					16:19	situ	16:19	situ	16:19	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial.
34058205	0	47	theme	carbonate	78:86	arg1	composites					92:101	bacterial cellulose/calcium carbonate bio composites	50:101	bacterial cellulose/calcium carbonate bio composites	50:101	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial.
34058205	6	48	theme	new	1012:1014	arg1	opportunities					1016:1028	new opportunities	1012:1028	new opportunities	1012:1028	The exploitation of organisms for inorganic growth, shape and self-assembling explores new opportunities to the design of original nanostructures.
34058205	4	49	theme	BC	771:772	arg1	network					774:780	BC network	771:780	BC network	771:780	During the preparation of nanocomposites, the calcium ions embedded on the cellulose fibrils were served as the nucleation center and calcium carbonate was deposited into BC network in the assistance of CO2.
34058205	1	50	from	approach	202:209	arg1	field					218:222	the field	214:222	the field of research	214:234	Biomineralization inspired process to produce polymer of desired need is a promising approach in the field of research.
34058205	2	51	theme	biological	349:358	arg1	route					360:364	a biological route	347:364	a biological route	347:364	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	0	52	theme	cellulose/calcium	60:76	arg1	composites					92:101	bacterial cellulose/calcium carbonate bio composites	50:101	bacterial cellulose/calcium carbonate bio composites	50:101	Gas assisted in situ biomimetic mineralization of bacterial cellulose/calcium carbonate bio composites by bacterial.
34058205	2	53	theme	metabolites	406:416	arg1	salt					390:393	the calcium salt	378:393	the calcium salt of primary metabolites (calcium gluconate)	378:436	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	2	53	theme	metabolites	406:416	arg1	source					452:457	the carbon source	441:457	the carbon source	441:457	In the present work, the bacterial cellulose (BC) based nanocomposites with a 3D network were synthesized via a biological route by choosing the calcium salt of primary metabolites (calcium gluconate) as the carbon source.
34058205	4	54	theme	calcium	646:652	arg1	ions					654:657	the calcium ions	642:657	the calcium ions embedded on the cellulose fibrils	642:691	During the preparation of nanocomposites, the calcium ions embedded on the cellulose fibrils were served as the nucleation center and calcium carbonate was deposited into BC network in the assistance of CO2.
34127230	6	0	theme	layer	856:860	arg1	porosity					836:843	porosity	836:843	porosity	836:843	The thickness, density, and porosity of the CNP layer exhibited correlations with OTR.
34127230	6	0	theme	layer	856:860	arg1	thickness					812:820	thickness	812:820	thickness	812:820	The thickness, density, and porosity of the CNP layer exhibited correlations with OTR.
34127230	6	0	theme	layer	856:860	arg1	density					823:829	density	823:829	density	823:829	The thickness, density, and porosity of the CNP layer exhibited correlations with OTR.
34127230	4	1	theme	different	664:672	arg1	values					674:679	different values	664:679	different values for the oxygen transmission rate (OTR)	664:718	The aspect ratio of the CNPs was shown to affect the film microstructure, resulting in different values for the oxygen transmission rate (OTR).
34127230	5	2	theme	well-organized	725:738	arg1	layer					744:748	The well-organized CNP layer	721:748	The well-organized CNP layer	721:748	The well-organized CNP layer exhibited lower OTR when compared with the network layer.
34127230	6	3	theme	CNP	852:854	arg1	layer					856:860	the CNP layer	848:860	the CNP layer	848:860	The thickness, density, and porosity of the CNP layer exhibited correlations with OTR.
34127230	3	4	theme	water	498:502	arg1	molecules					504:512	water molecules	498:512	water molecules	498:512	The BOPP as a substrate created a barrier to hinder the transmission of water molecules to the adhesive AR layer and gas barrier functional CNP layer.
34127230	8	5	theme	light	1095:1099	arg1	transmittance					1101:1113	excellent light transmittance	1085:1113	excellent light transmittance	1085:1113	Moreover, these sandwiched cellulose composite films showed excellent light transmittance and tensile strength.
34127230	2	6	theme	oriented	323:330	arg1	BOPP					347:350	BOPP	347:350	BOPP	347:350	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	2	6	theme	oriented	323:330	arg1	polypropylene					332:344	biaxially oriented polypropylene	313:344	biaxially oriented polypropylene (BOPP)	313:351	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	3	7	theme	gas	543:545	arg1	barrier					547:553	gas barrier	543:553	gas barrier	543:553	The BOPP as a substrate created a barrier to hinder the transmission of water molecules to the adhesive AR layer and gas barrier functional CNP layer.
34127230	8	8	theme	excellent	1085:1093	arg1	transmittance					1101:1113	excellent light transmittance	1085:1113	excellent light transmittance	1085:1113	Moreover, these sandwiched cellulose composite films showed excellent light transmittance and tensile strength.
34127230	4	9	theme	transmission	696:707	arg1	OTR					715:717	OTR	715:717	OTR	715:717	The aspect ratio of the CNPs was shown to affect the film microstructure, resulting in different values for the oxygen transmission rate (OTR).
34127230	4	9	theme	transmission	696:707	arg1	rate					709:712	the oxygen transmission rate	685:712	the oxygen transmission rate (OTR)	685:718	The aspect ratio of the CNPs was shown to affect the film microstructure, resulting in different values for the oxygen transmission rate (OTR).
34127230	5	10	theme	network	793:799	arg1	layer					801:805	the network layer	789:805	the network layer	789:805	The well-organized CNP layer exhibited lower OTR when compared with the network layer.
34127230	5	11	theme	lower	760:764	arg1	OTR					766:768	lower OTR	760:768	lower OTR	760:768	The well-organized CNP layer exhibited lower OTR when compared with the network layer.
34127230	6	12	with	correlations	872:883	arg1	OTR					890:892	OTR	890:892	OTR	890:892	The thickness, density, and porosity of the CNP layer exhibited correlations with OTR.
34127230	1	13	theme	Transparent	84:94	arg1	materials					108:116	Transparent gas barrier materials	84:116	Transparent gas barrier materials	84:116	Transparent gas barrier materials have extensive applications in packaging, pharmaceutical preservation, and electronics.
34127230	2	14	theme	nanoparticle	400:411	arg1	layer					419:423	a cellulose nanoparticle (CNP) layer	388:423	a cellulose nanoparticle (CNP) layer	388:423	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	0	15	theme	oxygen	12:17	arg1	barrier					19:25	Transparent oxygen barrier	0:25	Transparent oxygen barrier	0:25	Transparent oxygen barrier nanocellulose composite films with a sandwich structure.
34127230	8	16	theme	tensile	1119:1125	arg1	strength					1127:1134	tensile strength	1119:1134	tensile strength	1119:1134	Moreover, these sandwiched cellulose composite films showed excellent light transmittance and tensile strength.
34127230	1	17	theme	gas	96:98	arg1	materials					108:116	Transparent gas barrier materials	84:116	Transparent gas barrier materials	84:116	Transparent gas barrier materials have extensive applications in packaging, pharmaceutical preservation, and electronics.
34127230	2	18	theme	cellulose	390:398	arg1	layer					419:423	a cellulose nanoparticle (CNP) layer	388:423	a cellulose nanoparticle (CNP) layer	388:423	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	0	19	theme	Transparent	0:10	arg1	barrier					19:25	Transparent oxygen barrier	0:25	Transparent oxygen barrier	0:25	Transparent oxygen barrier nanocellulose composite films with a sandwich structure.
34127230	1	20	theme	barrier	100:106	arg1	materials					108:116	Transparent gas barrier materials	84:116	Transparent gas barrier materials	84:116	Transparent gas barrier materials have extensive applications in packaging, pharmaceutical preservation, and electronics.
34127230	4	21	theme	film	630:633	arg1	microstructure					635:648	the film microstructure	626:648	the film microstructure	626:648	The aspect ratio of the CNPs was shown to affect the film microstructure, resulting in different values for the oxygen transmission rate (OTR).
34127230	2	22	with	films	238:242	arg1	structure					270:278	a symmetric sandwich structure	249:278	a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer	249:423	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	7	23	theme	transmission	999:1010	arg1	WVTR					1018:1021	WVTR	1018:1021	WVTR	1018:1021	The water molecules were able to flow in through an additional pathway, thus increasing the water vapor transmission rate (WVTR).
34127230	7	23	theme	transmission	999:1010	arg1	rate					1012:1015	the water vapor transmission rate	983:1015	the water vapor transmission rate (WVTR)	983:1022	The water molecules were able to flow in through an additional pathway, thus increasing the water vapor transmission rate (WVTR).
34127230	7	24	theme	water	899:903	arg1	able					920:923	able	920:923	able	920:923	The water molecules were able to flow in through an additional pathway, thus increasing the water vapor transmission rate (WVTR).
34127230	7	24	theme	water	899:903	arg1	molecules					905:913	The water molecules	895:913	The water molecules	895:913	The water molecules were able to flow in through an additional pathway, thus increasing the water vapor transmission rate (WVTR).
34127230	3	25	theme	functional	555:564	arg1	layer					570:574	functional CNP layer	555:574	functional CNP layer	555:574	The BOPP as a substrate created a barrier to hinder the transmission of water molecules to the adhesive AR layer and gas barrier functional CNP layer.
34127230	2	26	theme	polypropylene	332:344	arg1	assembly					301:308	layer-by-layer assembly	286:308	layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer	286:423	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	4	27	theme	CNPs	601:604	arg1	ratio					588:592	The aspect ratio	577:592	The aspect ratio of the CNPs	577:604	The aspect ratio of the CNPs was shown to affect the film microstructure, resulting in different values for the oxygen transmission rate (OTR).
34127230	5	28	theme	CNP	740:742	arg1	layer					744:748	The well-organized CNP layer	721:748	The well-organized CNP layer	721:748	The well-organized CNP layer exhibited lower OTR when compared with the network layer.
34127230	7	29	theme	water	987:991	arg1	WVTR					1018:1021	WVTR	1018:1021	WVTR	1018:1021	The water molecules were able to flow in through an additional pathway, thus increasing the water vapor transmission rate (WVTR).
34127230	7	29	theme	water	987:991	arg1	rate					1012:1015	the water vapor transmission rate	983:1015	the water vapor transmission rate (WVTR)	983:1022	The water molecules were able to flow in through an additional pathway, thus increasing the water vapor transmission rate (WVTR).
34127230	2	30	theme	symmetric	251:259	arg1	structure					270:278	a symmetric sandwich structure	249:278	a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer	249:423	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	0	31	theme	composite	41:49	arg1	films					51:55	composite films	41:55	composite films with a sandwich structure	41:81	Transparent oxygen barrier nanocellulose composite films with a sandwich structure.
34127230	1	32	contain	have	118:121	arg1	materials					108:116	Transparent gas barrier materials	84:116	Transparent gas barrier materials	84:116	Transparent gas barrier materials have extensive applications in packaging, pharmaceutical preservation, and electronics.
34127230	1	32	contain	have	118:121	arg2	applications					133:144	extensive applications	123:144	extensive applications	123:144	Transparent gas barrier materials have extensive applications in packaging, pharmaceutical preservation, and electronics.
34127230	7	33	theme	vapor	993:997	arg1	WVTR					1018:1021	WVTR	1018:1021	WVTR	1018:1021	The water molecules were able to flow in through an additional pathway, thus increasing the water vapor transmission rate (WVTR).
34127230	7	33	theme	vapor	993:997	arg1	rate					1012:1015	the water vapor transmission rate	983:1015	the water vapor transmission rate (WVTR)	983:1022	The water molecules were able to flow in through an additional pathway, thus increasing the water vapor transmission rate (WVTR).
34127230	7	34	theme	additional	947:956	arg1	pathway					958:964	an additional pathway	944:964	an additional pathway	944:964	The water molecules were able to flow in through an additional pathway, thus increasing the water vapor transmission rate (WVTR).
34127230	2	35	theme	CNP	414:416	arg1	layer					419:423	a cellulose nanoparticle (CNP) layer	388:423	a cellulose nanoparticle (CNP) layer	388:423	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	8	36	theme	cellulose	1052:1060	arg1	films					1072:1076	these sandwiched cellulose composite films	1035:1076	these sandwiched cellulose composite films	1035:1076	Moreover, these sandwiched cellulose composite films showed excellent light transmittance and tensile strength.
34127230	3	37	theme	CNP	566:568	arg1	layer					570:574	functional CNP layer	555:574	functional CNP layer	555:574	The BOPP as a substrate created a barrier to hinder the transmission of water molecules to the adhesive AR layer and gas barrier functional CNP layer.
34127230	1	38	theme	extensive	123:131	arg1	applications					133:144	extensive applications	123:144	extensive applications	123:144	Transparent gas barrier materials have extensive applications in packaging, pharmaceutical preservation, and electronics.
34127230	4	39	theme	aspect	581:586	arg1	ratio					588:592	The aspect ratio	577:592	The aspect ratio of the CNPs	577:604	The aspect ratio of the CNPs was shown to affect the film microstructure, resulting in different values for the oxygen transmission rate (OTR).
34127230	2	40	theme	transparent	226:236	arg1	films					238:242	transparent films	226:242	transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer	226:423	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	2	41	theme	resin	365:369	arg1	assembly					301:308	layer-by-layer assembly	286:308	layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer	286:423	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	8	42	theme	sandwiched	1041:1050	arg1	films					1072:1076	these sandwiched cellulose composite films	1035:1076	these sandwiched cellulose composite films	1035:1076	Moreover, these sandwiched cellulose composite films showed excellent light transmittance and tensile strength.
34127230	2	43	theme	layer-by-layer	286:299	arg1	assembly					301:308	layer-by-layer assembly	286:308	layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer	286:423	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	2	44	theme	acrylic	357:363	arg1	resin					365:369	acrylic resin	357:369	acrylic resin (AR)	357:374	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	2	44	theme	acrylic	357:363	arg1	AR					372:373	AR	372:373	AR	372:373	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	3	45	theme	adhesive	521:528	arg1	layer					533:537	the adhesive AR layer	517:537	the adhesive AR layer	517:537	The BOPP as a substrate created a barrier to hinder the transmission of water molecules to the adhesive AR layer and gas barrier functional CNP layer.
34127230	3	46	theme	AR	530:531	arg1	layer					533:537	the adhesive AR layer	517:537	the adhesive AR layer	517:537	The BOPP as a substrate created a barrier to hinder the transmission of water molecules to the adhesive AR layer and gas barrier functional CNP layer.
34127230	3	47	dep	layer	533:537	arg1	layer					570:574	functional CNP layer	555:574	functional CNP layer	555:574	The BOPP as a substrate created a barrier to hinder the transmission of water molecules to the adhesive AR layer and gas barrier functional CNP layer.
34127230	4	48	theme	oxygen	689:694	arg1	OTR					715:717	OTR	715:717	OTR	715:717	The aspect ratio of the CNPs was shown to affect the film microstructure, resulting in different values for the oxygen transmission rate (OTR).
34127230	4	48	theme	oxygen	689:694	arg1	rate					709:712	the oxygen transmission rate	685:712	the oxygen transmission rate (OTR)	685:718	The aspect ratio of the CNPs was shown to affect the film microstructure, resulting in different values for the oxygen transmission rate (OTR).
34127230	8	49	theme	composite	1062:1070	arg1	films					1072:1076	these sandwiched cellulose composite films	1035:1076	these sandwiched cellulose composite films	1035:1076	Moreover, these sandwiched cellulose composite films showed excellent light transmittance and tensile strength.
34127230	3	50	theme	molecules	504:512	arg1	transmission					482:493	the transmission	478:493	the transmission of water molecules to the adhesive AR layer and gas barrier functional CNP layer	478:574	The BOPP as a substrate created a barrier to hinder the transmission of water molecules to the adhesive AR layer and gas barrier functional CNP layer.
34127230	0	51	theme	sandwich	64:71	arg1	structure					73:81	a sandwich structure	62:81	a sandwich structure	62:81	Transparent oxygen barrier nanocellulose composite films with a sandwich structure.
34127230	2	52	theme	sandwich	261:268	arg1	structure					270:278	a symmetric sandwich structure	249:278	a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer	249:423	Herein, we designed transparent films with a symmetric sandwich structure using layer-by-layer assembly of biaxially oriented polypropylene (BOPP) and acrylic resin (AR) followed by a cellulose nanoparticle (CNP) layer.
34127230	0	53	with	films	51:55	arg1	structure					73:81	a sandwich structure	62:81	a sandwich structure	62:81	Transparent oxygen barrier nanocellulose composite films with a sandwich structure.
34127230	1	54	theme	pharmaceutical	160:173	arg1	preservation					175:186	pharmaceutical preservation	160:186	pharmaceutical preservation	160:186	Transparent gas barrier materials have extensive applications in packaging, pharmaceutical preservation, and electronics.
34071348	0	0	theme	Glycosyl	112:119	arg1	Enzyme					133:138	Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme	77:138	Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme	77:138	Computational Study on Temperature Driven Structure-Function Relationship of Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme.
34071348	8	1	theme	bacterial	1470:1478	arg1	production					1495:1504	industrial-level bacterial polysaccharide production	1453:1504	industrial-level bacterial polysaccharide production	1453:1504	The results from this study may direct utilization of thermophile-origin GT as best for industrial-level bacterial polysaccharide production.
34071348	7	2	theme	increased	1265:1273	arg1	number					1275:1280	an increased number	1262:1280	an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser)	1262:1362	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	0	3	theme	Bacterial	102:110	arg1	Enzyme					133:138	Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme	77:138	Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme	77:138	Computational Study on Temperature Driven Structure-Function Relationship of Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme.
34071348	0	4	from	Study	14:18	arg1	Temperature					23:33	Temperature	23:33	Temperature	23:33	Computational Study on Temperature Driven Structure-Function Relationship of Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme.
34071348	7	5	dep	demonstrated	1202:1213	arg1	-10.70					1249:1254	-10.70	1249:1254	-10.70	1249:1254	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	2	6	theme	bacterial	345:353	arg1	EPSs					355:358	bacterial EPSs	345:358	bacterial EPSs	345:358	In recent years, increased demand for bacterial EPSs has been observed in pharmaceutical, food, and other industries.
34071348	6	7	theme	structural	989:998	arg1	plasticity					1000:1009	the structural plasticity	985:1009	the structural plasticity	985:1009	In contrast, the structural plasticity runs in an opposite direction towards mesophile.
34071348	0	8	theme	Enzyme	133:138	arg1	Relationship					61:72	Structure-Function Relationship	42:72	Structure-Function Relationship of Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme	42:138	Computational Study on Temperature Driven Structure-Function Relationship of Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme.
34071348	7	9	theme	GT-UDP-glucose	1136:1149	arg1	interactions					1151:1162	the GT-UDP-glucose interactions	1132:1162	the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser)	1132:1362	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	4	10	dep	temperature	681:691	arg1	hyperthermophile					722:737	hyperthermophile	722:737	hyperthermophile	722:737	Keeping this in context, EPS producing GT enzymes from three different bacterial sources based on growth temperature (mesophile, thermophile, and hyperthermophile) are considered for in silico analysis of the structural-functional relationship.
34071348	4	10	dep	temperature	681:691	arg1	mesophile					694:702	mesophile	694:702	mesophile	694:702	Keeping this in context, EPS producing GT enzymes from three different bacterial sources based on growth temperature (mesophile, thermophile, and hyperthermophile) are considered for in silico analysis of the structural-functional relationship.
34071348	4	10	dep	temperature	681:691	arg1	thermophile					705:715	thermophile	705:715	thermophile	705:715	Keeping this in context, EPS producing GT enzymes from three different bacterial sources based on growth temperature (mesophile, thermophile, and hyperthermophile) are considered for in silico analysis of the structural-functional relationship.
34071348	1	11	theme	bacterial	261:269	arg1	EPS					290:292	EPS	290:292	EPS	290:292	Glycosyltransferase (GTs) is a wide class of enzymes that transfer sugar moiety, playing a key role in the synthesis of bacterial exopolysaccharide (EPS) biopolymer.
34071348	1	11	theme	bacterial	261:269	arg1	exopolysaccharide					271:287	bacterial exopolysaccharide	261:287	bacterial exopolysaccharide (EPS) biopolymer	261:304	Glycosyltransferase (GTs) is a wide class of enzymes that transfer sugar moiety, playing a key role in the synthesis of bacterial exopolysaccharide (EPS) biopolymer.
34071348	0	12	theme	Transferase	121:131	arg1	Enzyme					133:138	Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme	77:138	Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme	77:138	Computational Study on Temperature Driven Structure-Function Relationship of Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme.
34071348	7	13	dep	acids	1328:1332	arg1	acids					1328:1332	stabilizing amino acids	1310:1332	stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser)	1310:1362	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	13	dep	acids	1328:1332	arg1	Phe					1335:1337	Phe	1335:1337	Phe	1335:1337	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	13	dep	acids	1328:1332	arg1	Tyr					1350:1352	Tyr	1350:1352	Tyr	1350:1352	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	13	dep	acids	1328:1332	arg1	Ser					1359:1361	Ser	1359:1361	Ser	1359:1361	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	13	dep	acids	1328:1332	arg1	Ala					1340:1342	Ala	1340:1342	Ala	1340:1342	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	1	14	theme	exopolysaccharide	271:287	arg1	biopolymer					295:304	bacterial exopolysaccharide (EPS) biopolymer	261:304	bacterial exopolysaccharide (EPS) biopolymer	261:304	Glycosyltransferase (GTs) is a wide class of enzymes that transfer sugar moiety, playing a key role in the synthesis of bacterial exopolysaccharide (EPS) biopolymer.
34071348	7	15	theme	acids	1328:1332	arg1	number					1275:1280	an increased number	1262:1280	an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser)	1262:1362	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	3	16	theme	industrial	506:515	arg1	application					517:527	any industrial application	502:527	any industrial application	502:527	The application of the EPSs largely depends upon their thermal stability, as any industrial application is mainly reliant on slow thermal degradation.
34071348	1	17	theme	enzymes	186:192	arg1	class					177:181	a wide class	170:181	a wide class of enzymes that transfer sugar moiety, playing a key role in the synthesis of bacterial exopolysaccharide (EPS) biopolymer	170:304	Glycosyltransferase (GTs) is a wide class of enzymes that transfer sugar moiety, playing a key role in the synthesis of bacterial exopolysaccharide (EPS) biopolymer.
34071348	1	17	theme	enzymes	186:192	arg1	Glycosyltransferase					141:159	Glycosyltransferase	141:159	Glycosyltransferase (GTs)	141:165	Glycosyltransferase (GTs) is a wide class of enzymes that transfer sugar moiety, playing a key role in the synthesis of bacterial exopolysaccharide (EPS) biopolymer.
34071348	7	18	theme	structural	1099:1108	arg1	property					1110:1117	This interesting temperature-dependent structural property	1060:1117	This interesting temperature-dependent structural property	1060:1117	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	19	theme	binding	1222:1228	arg1	affinity					1230:1237	better binding affinity	1215:1237	better binding affinity	1215:1237	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	2	20	theme	pharmaceutical	381:394	arg1	industries					413:422	pharmaceutical, food, and other industries	381:422	pharmaceutical, food, and other industries	381:422	In recent years, increased demand for bacterial EPSs has been observed in pharmaceutical, food, and other industries.
34071348	7	21	theme	better	1215:1220	arg1	affinity					1230:1237	better binding affinity	1215:1237	better binding affinity	1215:1237	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	3	22	theme	slow	550:553	arg1	degradation					563:573	slow thermal degradation	550:573	slow thermal degradation	550:573	The application of the EPSs largely depends upon their thermal stability, as any industrial application is mainly reliant on slow thermal degradation.
34071348	6	23	theme	opposite	1022:1029	arg1	direction					1031:1039	an opposite direction	1019:1039	an opposite direction towards mesophile	1019:1057	In contrast, the structural plasticity runs in an opposite direction towards mesophile.
34071348	0	24	theme	Computational	0:12	arg1	Study					14:18	Computational Study	0:18	Computational Study on Temperature	0:33	Computational Study on Temperature Driven Structure-Function Relationship of Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme.
34071348	2	25	theme	recent	310:315	arg1	years					317:321	recent years	310:321	recent years	310:321	In recent years, increased demand for bacterial EPSs has been observed in pharmaceutical, food, and other industries.
34071348	1	26	theme	sugar	208:212	arg1	moiety					214:219	sugar moiety	208:219	sugar moiety	208:219	Glycosyltransferase (GTs) is a wide class of enzymes that transfer sugar moiety, playing a key role in the synthesis of bacterial exopolysaccharide (EPS) biopolymer.
34071348	8	27	theme	industrial-level	1453:1468	arg1	production					1495:1504	industrial-level bacterial polysaccharide production	1453:1504	industrial-level bacterial polysaccharide production	1453:1504	The results from this study may direct utilization of thermophile-origin GT as best for industrial-level bacterial polysaccharide production.
34071348	7	28	theme	temperature-dependent	1077:1097	arg1	property					1110:1117	This interesting temperature-dependent structural property	1060:1117	This interesting temperature-dependent structural property	1060:1117	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	2	29	theme	other	407:411	arg1	industries					413:422	pharmaceutical, food, and other industries	381:422	pharmaceutical, food, and other industries	381:422	In recent years, increased demand for bacterial EPSs has been observed in pharmaceutical, food, and other industries.
34071348	3	30	theme	thermal	555:561	arg1	degradation					563:573	slow thermal degradation	550:573	slow thermal degradation	550:573	The application of the EPSs largely depends upon their thermal stability, as any industrial application is mainly reliant on slow thermal degradation.
34071348	4	31	theme	in	759:760	arg1	analysis					769:776	in silico analysis	759:776	in silico analysis of the structural-functional relationship	759:818	Keeping this in context, EPS producing GT enzymes from three different bacterial sources based on growth temperature (mesophile, thermophile, and hyperthermophile) are considered for in silico analysis of the structural-functional relationship.
34071348	4	32	theme	growth	674:679	arg1	temperature					681:691	growth temperature	674:691	growth temperature (mesophile, thermophile, and hyperthermophile)	674:738	Keeping this in context, EPS producing GT enzymes from three different bacterial sources based on growth temperature (mesophile, thermophile, and hyperthermophile) are considered for in silico analysis of the structural-functional relationship.
34071348	8	33	from	study	1387:1391	arg1	results					1369:1375	The results	1365:1375	The results from this study	1365:1391	The results from this study may direct utilization of thermophile-origin GT as best for industrial-level bacterial polysaccharide production.
34071348	5	34	theme	present	830:836	arg1	study					838:842	the present study	826:842	the present study	826:842	From the present study, it was observed that the structural integrity of GT increases significantly from mesophile to thermophile to hyperthermophile.
34071348	0	35	theme	Structure-Function	42:59	arg1	Relationship					61:72	Structure-Function Relationship	42:72	Structure-Function Relationship of Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme	42:138	Computational Study on Temperature Driven Structure-Function Relationship of Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme.
34071348	1	36	theme	biopolymer	295:304	arg1	synthesis					248:256	the synthesis	244:256	the synthesis of bacterial exopolysaccharide (EPS) biopolymer	244:304	Glycosyltransferase (GTs) is a wide class of enzymes that transfer sugar moiety, playing a key role in the synthesis of bacterial exopolysaccharide (EPS) biopolymer.
34071348	4	37	theme	relationship	807:818	arg1	analysis					769:776	in silico analysis	759:776	in silico analysis of the structural-functional relationship	759:818	Keeping this in context, EPS producing GT enzymes from three different bacterial sources based on growth temperature (mesophile, thermophile, and hyperthermophile) are considered for in silico analysis of the structural-functional relationship.
34071348	4	38	theme	bacterial	647:655	arg1	sources					657:663	three different bacterial sources	631:663	three different bacterial sources based on growth temperature (mesophile, thermophile, and hyperthermophile)	631:738	Keeping this in context, EPS producing GT enzymes from three different bacterial sources based on growth temperature (mesophile, thermophile, and hyperthermophile) are considered for in silico analysis of the structural-functional relationship.
34071348	4	39	theme	different	637:645	arg1	sources					657:663	three different bacterial sources	631:663	three different bacterial sources based on growth temperature (mesophile, thermophile, and hyperthermophile)	631:738	Keeping this in context, EPS producing GT enzymes from three different bacterial sources based on growth temperature (mesophile, thermophile, and hyperthermophile) are considered for in silico analysis of the structural-functional relationship.
34071348	7	40	theme	interesting	1065:1075	arg1	property					1110:1117	This interesting temperature-dependent structural property	1060:1117	This interesting temperature-dependent structural property	1060:1117	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	8	41	theme	GT	1438:1439	arg1	utilization					1404:1414	utilization	1404:1414	utilization of thermophile-origin GT	1404:1439	The results from this study may direct utilization of thermophile-origin GT as best for industrial-level bacterial polysaccharide production.
34071348	4	42	theme	structural-functional	785:805	arg1	relationship					807:818	the structural-functional relationship	781:818	the structural-functional relationship	781:818	Keeping this in context, EPS producing GT enzymes from three different bacterial sources based on growth temperature (mesophile, thermophile, and hyperthermophile) are considered for in silico analysis of the structural-functional relationship.
34071348	2	43	theme	food	397:400	arg1	industries					413:422	pharmaceutical, food, and other industries	381:422	pharmaceutical, food, and other industries	381:422	In recent years, increased demand for bacterial EPSs has been observed in pharmaceutical, food, and other industries.
34071348	7	44	from	interactions	1151:1162	arg1	way					1169:1171	a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser)	1167:1362	a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser)	1167:1362	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	8	45	theme	thermophile-origin	1419:1436	arg1	GT					1438:1439	thermophile-origin GT	1419:1439	thermophile-origin GT	1419:1439	The results from this study may direct utilization of thermophile-origin GT as best for industrial-level bacterial polysaccharide production.
34071348	5	46	theme	GT	894:895	arg1	integrity					881:889	the structural integrity	866:889	the structural integrity of GT	866:895	From the present study, it was observed that the structural integrity of GT increases significantly from mesophile to thermophile to hyperthermophile.
34071348	7	47	dep	-10.70	1249:1254	arg1	to					1246:1247	to	1246:1247	to	1246:1247	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	3	48	theme	thermal	480:486	arg1	stability					488:496	their thermal stability	474:496	their thermal stability	474:496	The application of the EPSs largely depends upon their thermal stability, as any industrial application is mainly reliant on slow thermal degradation.
34071348	7	49	theme	hydrogen	1285:1292	arg1	355					1301:1303	355	1301:1303	355	1301:1303	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	49	theme	hydrogen	1285:1292	arg1	bonds					1294:1298	hydrogen bonds	1285:1298	hydrogen bonds (355)	1285:1304	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	2	50	theme	increased	324:332	arg1	demand					334:339	increased demand	324:339	increased demand for bacterial EPSs	324:358	In recent years, increased demand for bacterial EPSs has been observed in pharmaceutical, food, and other industries.
34071348	1	51	theme	key	232:234	arg1	role					236:239	a key role	230:239	a key role	230:239	Glycosyltransferase (GTs) is a wide class of enzymes that transfer sugar moiety, playing a key role in the synthesis of bacterial exopolysaccharide (EPS) biopolymer.
34071348	2	52	located	observed	369:376	arg1	industries					413:422	pharmaceutical, food, and other industries	381:422	pharmaceutical, food, and other industries	381:422	In recent years, increased demand for bacterial EPSs has been observed in pharmaceutical, food, and other industries.
34071348	2	52	located	observed	369:376	arg2	demand					334:339	increased demand	324:339	increased demand for bacterial EPSs	324:358	In recent years, increased demand for bacterial EPSs has been observed in pharmaceutical, food, and other industries.
34071348	2	52	located	observed	369:376	arg1	years					317:321	recent years	310:321	recent years	310:321	In recent years, increased demand for bacterial EPSs has been observed in pharmaceutical, food, and other industries.
34071348	5	53	theme	structural	870:879	arg1	integrity					881:889	the structural integrity	866:889	the structural integrity of GT	866:895	From the present study, it was observed that the structural integrity of GT increases significantly from mesophile to thermophile to hyperthermophile.
34071348	7	54	theme	bonds	1294:1298	arg1	number					1275:1280	an increased number	1262:1280	an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser)	1262:1362	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	0	55	theme	Producing	92:100	arg1	Enzyme					133:138	Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme	77:138	Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme	77:138	Computational Study on Temperature Driven Structure-Function Relationship of Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme.
34071348	7	56	theme	stabilizing	1310:1320	arg1	Phe					1335:1337	Phe	1335:1337	Phe	1335:1337	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	56	theme	stabilizing	1310:1320	arg1	acids					1328:1332	stabilizing amino acids	1310:1332	stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser)	1310:1362	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	56	theme	stabilizing	1310:1320	arg1	Ser					1359:1361	Ser	1359:1361	Ser	1359:1361	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	56	theme	stabilizing	1310:1320	arg1	Tyr					1350:1352	Tyr	1350:1352	Tyr	1350:1352	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	56	theme	stabilizing	1310:1320	arg1	Ala					1340:1342	Ala	1340:1342	Ala	1340:1342	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	3	57	theme	EPSs	448:451	arg1	application					429:439	The application	425:439	The application of the EPSs	425:451	The application of the EPSs largely depends upon their thermal stability, as any industrial application is mainly reliant on slow thermal degradation.
34071348	4	58	dep	in	759:760	arg1	silico					762:767	silico	762:767	silico	762:767	Keeping this in context, EPS producing GT enzymes from three different bacterial sources based on growth temperature (mesophile, thermophile, and hyperthermophile) are considered for in silico analysis of the structural-functional relationship.
34071348	7	59	theme	amino	1322:1326	arg1	Phe					1335:1337	Phe	1335:1337	Phe	1335:1337	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	59	theme	amino	1322:1326	arg1	acids					1328:1332	stabilizing amino acids	1310:1332	stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser)	1310:1362	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	59	theme	amino	1322:1326	arg1	Ser					1359:1361	Ser	1359:1361	Ser	1359:1361	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	59	theme	amino	1322:1326	arg1	Tyr					1350:1352	Tyr	1350:1352	Tyr	1350:1352	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	7	59	theme	amino	1322:1326	arg1	Ala					1340:1342	Ala	1340:1342	Ala	1340:1342	This interesting temperature-dependent structural property has directed the GT-UDP-glucose interactions in a way that thermophile has finally demonstrated better binding affinity (-5.57 to -10.70) with an increased number of hydrogen bonds (355) and stabilizing amino acids (Phe, Ala, Glu, Tyr, and Ser).
34071348	0	60	theme	Polysaccharide	77:90	arg1	Enzyme					133:138	Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme	77:138	Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme	77:138	Computational Study on Temperature Driven Structure-Function Relationship of Polysaccharide Producing Bacterial Glycosyl Transferase Enzyme.
34071348	8	61	theme	polysaccharide	1480:1493	arg1	production					1495:1504	industrial-level bacterial polysaccharide production	1453:1504	industrial-level bacterial polysaccharide production	1453:1504	The results from this study may direct utilization of thermophile-origin GT as best for industrial-level bacterial polysaccharide production.
34071348	4	62	theme	GT	615:616	arg1	enzymes					618:624	GT enzymes	615:624	GT enzymes	615:624	Keeping this in context, EPS producing GT enzymes from three different bacterial sources based on growth temperature (mesophile, thermophile, and hyperthermophile) are considered for in silico analysis of the structural-functional relationship.
34071348	1	63	theme	wide	172:175	arg1	class					177:181	a wide class	170:181	a wide class of enzymes that transfer sugar moiety, playing a key role in the synthesis of bacterial exopolysaccharide (EPS) biopolymer	170:304	Glycosyltransferase (GTs) is a wide class of enzymes that transfer sugar moiety, playing a key role in the synthesis of bacterial exopolysaccharide (EPS) biopolymer.
34071348	1	63	theme	wide	172:175	arg1	Glycosyltransferase					141:159	Glycosyltransferase	141:159	Glycosyltransferase (GTs)	141:165	Glycosyltransferase (GTs) is a wide class of enzymes that transfer sugar moiety, playing a key role in the synthesis of bacterial exopolysaccharide (EPS) biopolymer.
34586146	0	0	theme	polypyrrole-grafted	93:111	arg1	gelatin					113:119	oxidized alginate and polypyrrole-grafted gelatin	71:119	oxidized alginate and polypyrrole-grafted gelatin as tissue scaffolds	71:139	Synthesis and characterization of electroconductive hydrogels based on oxidized alginate and polypyrrole-grafted gelatin as tissue scaffolds.
34586146	2	1	theme	Schiff-base	564:574	arg1	linkage					576:582	a Schiff-base linkage	562:582	a Schiff-base linkage	562:582	In the present study, novel electroconductive hydrogels are designed and synthesized by reacting oxidized alginate with polypyrrole-grafted gelatin copolymer (PPy-g-gelatin) via formation of a Schiff-base linkage.
34586146	4	2	theme	8	954:954	arg1	%					955:955	%	955:955	%	955:955	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	8	3	theme	higher	1562:1567	arg1	result					1594:1599	a result	1592:1599	a result of easier movement of the ions throughout the hydrogel	1592:1654	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	8	3	theme	higher	1562:1567	arg1	electroconductivity					1569:1587	higher electroconductivity	1562:1587	higher electroconductivity	1562:1587	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	5	4	theme	total	1141:1145	arg1	concentration					1147:1159	the total concentration	1137:1159	the total concentration of hydrogel	1137:1171	The hydrogel compressive modulus was shown to be enhanced by increasing the total concentration of hydrogel.
34586146	6	5	theme	hydrogels	1218:1226	arg1	fraction					1262:1269	volume fraction	1255:1269	volume fraction	1255:1269	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	6	5	theme	hydrogels	1218:1226	arg1	density					1283:1289	cross-link density	1272:1289	cross-link density	1272:1289	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	6	5	theme	hydrogels	1218:1226	arg1	ratio					1248:1252	swelling ratio	1239:1252	swelling ratio	1239:1252	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	6	5	theme	hydrogels	1218:1226	arg1	size					1301:1304	mesh size	1296:1304	mesh size	1296:1304	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	6	5	theme	hydrogels	1218:1226	arg1	features					1193:1200	The characteristic features	1174:1200	The characteristic features	1174:1200	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	4	6	theme	m-1	908:910	arg1	conductivity					883:894	a conductivity	881:894	a conductivity of 0.7753 S m-1	881:910	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	9	7	theme	electrical	1694:1703	arg1	conductivity					1705:1716	electrical conductivity	1694:1716	electrical conductivity	1694:1716	These conductive hydrogels exhibited electrical conductivity and biodegradability with cell viability, implying potential as scaffolds for tissue engineering.
34586146	2	8	theme	electroconductive	399:415	arg1	hydrogels					417:425	novel electroconductive hydrogels	393:425	novel electroconductive hydrogels	393:425	In the present study, novel electroconductive hydrogels are designed and synthesized by reacting oxidized alginate with polypyrrole-grafted gelatin copolymer (PPy-g-gelatin) via formation of a Schiff-base linkage.
34586146	8	9	theme	high	1490:1493	arg1	density					1506:1512	high cross-link density	1490:1512	high cross-link density	1490:1512	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	8	10	theme	large	1536:1540	arg1	size					1547:1550	large pore size	1536:1550	large pore size	1536:1550	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	4	11	theme	w/v	957:959	arg1	gelatin					981:987	8% w/v polypyrrole-grafted gelatin	954:987	8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v)	954:1062	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	4	11	theme	w/v	957:959	arg1	alginate					999:1006	oxidized alginate	990:1006	oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 	990:1052	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	3	12	from	influence	589:597	arg1	performance					700:710	the compressive modulus and functional performance	661:710	the compressive modulus and functional performance of the hydrogels	661:727	The influence of the composition and the concentration of the components on the compressive modulus and functional performance of the hydrogels is investigated.
34586146	4	13	theme	gelatin	868:874	arg1	level					839:843	the level	835:843	the level of polypyrrole-grafted gelatin	835:874	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	4	14	theme	polypyrrole-grafted	1016:1034	arg1	gelatin					1036:1042	polypyrrole-grafted gelatin	1016:1042	oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 	990:1052	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	2	15	with	alginate	477:484	arg1	gelatin					511:517	polypyrrole-grafted gelatin	491:517	polypyrrole-grafted gelatin	491:517	In the present study, novel electroconductive hydrogels are designed and synthesized by reacting oxidized alginate with polypyrrole-grafted gelatin copolymer (PPy-g-gelatin) via formation of a Schiff-base linkage.
34586146	4	16	theme	polypyrrole-grafted	848:866	arg1	gelatin					868:874	polypyrrole-grafted gelatin	848:874	polypyrrole-grafted gelatin	848:874	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	3	17	theme	concentration	626:638	arg1	influence					589:597	The influence	585:597	The influence of the composition and the concentration of the components on the compressive modulus and functional performance of the hydrogels	585:727	The influence of the composition and the concentration of the components on the compressive modulus and functional performance of the hydrogels is investigated.
34586146	1	18	theme	suitable	318:325	arg1	responses					346:354	suitable microenvironmental responses	318:354	suitable microenvironmental responses	318:354	Electroconductive biocompatible hydrogels with tunable properties have extensively been taken into account in tissue engineering applications due to their potential to provide suitable microenvironmental responses for the cells.
34586146	3	19	dep	composition	606:616	arg1	the					602:604	the	602:604	the	602:604	The influence of the composition and the concentration of the components on the compressive modulus and functional performance of the hydrogels is investigated.
34586146	3	20	theme	composition	606:616	arg1	influence					589:597	The influence	585:597	The influence of the composition and the concentration of the components on the compressive modulus and functional performance of the hydrogels	585:727	The influence of the composition and the concentration of the components on the compressive modulus and functional performance of the hydrogels is investigated.
34586146	7	21	theme	smaller	1379:1385	arg1	size					1392:1395	a smaller mesh size	1377:1395	a smaller mesh size	1377:1395	Besides, the conductive hydrogels have a smaller mesh size and higher cross-link density than the non-conductive hydrogels.
34586146	0	22	theme	tissue	124:129	arg1	scaffolds					131:139	tissue scaffolds	124:139	tissue scaffolds	124:139	Synthesis and characterization of electroconductive hydrogels based on oxidized alginate and polypyrrole-grafted gelatin as tissue scaffolds.
34586146	1	23	with	hydrogels	174:182	arg1	properties					197:206	tunable properties	189:206	tunable properties	189:206	Electroconductive biocompatible hydrogels with tunable properties have extensively been taken into account in tissue engineering applications due to their potential to provide suitable microenvironmental responses for the cells.
34586146	8	24	theme	ions	1627:1630	arg1	movement					1611:1618	easier movement	1604:1618	easier movement of the ions throughout the hydrogel	1604:1654	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	5	25	theme	hydrogel	1069:1076	arg1	modulus					1090:1096	The hydrogel compressive modulus	1065:1096	The hydrogel compressive modulus	1065:1096	The hydrogel compressive modulus was shown to be enhanced by increasing the total concentration of hydrogel.
34586146	5	26	theme	hydrogel	1164:1171	arg1	concentration					1147:1159	the total concentration	1137:1159	the total concentration of hydrogel	1137:1171	The hydrogel compressive modulus was shown to be enhanced by increasing the total concentration of hydrogel.
34586146	9	27	theme	cell	1744:1747	arg1	viability					1749:1757	cell viability	1744:1757	cell viability	1744:1757	These conductive hydrogels exhibited electrical conductivity and biodegradability with cell viability, implying potential as scaffolds for tissue engineering.
34586146	3	28	theme	components	647:656	arg1	composition					606:616	composition	606:616	composition	606:616	The influence of the composition and the concentration of the components on the compressive modulus and functional performance of the hydrogels is investigated.
34586146	3	28	theme	components	647:656	arg1	concentration					626:638	the concentration	622:638	the concentration	622:638	The influence of the composition and the concentration of the components on the compressive modulus and functional performance of the hydrogels is investigated.
34586146	7	29	theme	conductive	1351:1360	arg1	hydrogels					1362:1370	the conductive hydrogels	1347:1370	the conductive hydrogels	1347:1370	Besides, the conductive hydrogels have a smaller mesh size and higher cross-link density than the non-conductive hydrogels.
34586146	8	30	theme	pore	1542:1545	arg1	size					1547:1550	large pore size	1536:1550	large pore size	1536:1550	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	1	31	theme	microenvironmental	327:344	arg1	responses					346:354	suitable microenvironmental responses	318:354	suitable microenvironmental responses	318:354	Electroconductive biocompatible hydrogels with tunable properties have extensively been taken into account in tissue engineering applications due to their potential to provide suitable microenvironmental responses for the cells.
34586146	6	32	theme	mesh	1296:1299	arg1	size					1301:1304	mesh size	1296:1304	mesh size	1296:1304	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	6	33	theme	prepared	1209:1216	arg1	hydrogels					1218:1226	the prepared hydrogels	1205:1226	the prepared hydrogels	1205:1226	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	7	34	theme	higher	1401:1406	arg1	density					1419:1425	higher cross-link density	1401:1425	higher cross-link density	1401:1425	Besides, the conductive hydrogels have a smaller mesh size and higher cross-link density than the non-conductive hydrogels.
34586146	6	35	theme	volume	1255:1260	arg1	fraction					1262:1269	volume fraction	1255:1269	volume fraction	1255:1269	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	8	36	theme	cross-link	1495:1504	arg1	density					1506:1512	high cross-link density	1490:1512	high cross-link density	1490:1512	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	6	37	theme	cross-link	1272:1281	arg1	density					1283:1289	cross-link density	1272:1289	cross-link density	1272:1289	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	3	38	theme	modulus	677:683	arg1	performance					700:710	the compressive modulus and functional performance	661:710	the compressive modulus and functional performance of the hydrogels	661:727	The influence of the composition and the concentration of the components on the compressive modulus and functional performance of the hydrogels is investigated.
34586146	2	39	theme	polypyrrole-grafted	491:509	arg1	gelatin					511:517	polypyrrole-grafted gelatin	491:517	polypyrrole-grafted gelatin	491:517	In the present study, novel electroconductive hydrogels are designed and synthesized by reacting oxidized alginate with polypyrrole-grafted gelatin copolymer (PPy-g-gelatin) via formation of a Schiff-base linkage.
34586146	8	40	theme	mesh	1521:1524	arg1	size					1526:1529	small mesh size	1515:1529	small mesh size	1515:1529	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	7	41	theme	non-conductive	1436:1449	arg1	hydrogels					1451:1459	the non-conductive hydrogels	1432:1459	the non-conductive hydrogels	1432:1459	Besides, the conductive hydrogels have a smaller mesh size and higher cross-link density than the non-conductive hydrogels.
34586146	4	42	dep	alginate	999:1006	arg1	 35 					1049:1052	 35 	1049:1052	oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 	990:1052	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	4	42	dep	alginate	999:1006	arg1	30 					1045:1047	30 	1045:1047	30 	1045:1047	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	4	42	dep	alginate	999:1006	arg1	gelatin					1008:1014	gelatin	1008:1014	oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 	990:1052	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	4	42	dep	alginate	999:1006	arg1	v/v					1059:1061	 35% v/v	1054:1061	 35% v/v	1054:1061	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	4	42	dep	alginate	999:1006	arg1	gelatin					1036:1042	polypyrrole-grafted gelatin	1016:1042	oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 	990:1052	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	0	43	theme	hydrogels	52:60	arg1	characterization					14:29	characterization	14:29	characterization	14:29	Synthesis and characterization of electroconductive hydrogels based on oxidized alginate and polypyrrole-grafted gelatin as tissue scaffolds.
34586146	0	43	theme	hydrogels	52:60	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis and characterization of electroconductive hydrogels based on oxidized alginate and polypyrrole-grafted gelatin as tissue scaffolds.
34586146	4	44	theme	two-probe	794:802	arg1	method					804:809	a two-probe method	792:809	a two-probe method	792:809	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	6	45	theme	characteristic	1178:1191	arg1	fraction					1262:1269	volume fraction	1255:1269	volume fraction	1255:1269	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	6	45	theme	characteristic	1178:1191	arg1	density					1283:1289	cross-link density	1272:1289	cross-link density	1272:1289	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	6	45	theme	characteristic	1178:1191	arg1	ratio					1248:1252	swelling ratio	1239:1252	swelling ratio	1239:1252	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	6	45	theme	characteristic	1178:1191	arg1	size					1301:1304	mesh size	1296:1304	mesh size	1296:1304	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	6	45	theme	characteristic	1178:1191	arg1	features					1193:1200	The characteristic features	1174:1200	The characteristic features	1174:1200	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	2	46	dep	alginate	477:484	arg1	PPy-g-gelatin					530:542	PPy-g-gelatin	530:542	PPy-g-gelatin	530:542	In the present study, novel electroconductive hydrogels are designed and synthesized by reacting oxidized alginate with polypyrrole-grafted gelatin copolymer (PPy-g-gelatin) via formation of a Schiff-base linkage.
34586146	2	46	dep	alginate	477:484	arg1	copolymer					519:527	copolymer	519:527	oxidized alginate with polypyrrole-grafted gelatin copolymer (PPy-g-gelatin)	468:543	In the present study, novel electroconductive hydrogels are designed and synthesized by reacting oxidized alginate with polypyrrole-grafted gelatin copolymer (PPy-g-gelatin) via formation of a Schiff-base linkage.
34586146	1	47	theme	tissue	252:257	arg1	applications					271:282	tissue engineering applications	252:282	tissue engineering applications due to their potential to provide suitable microenvironmental responses for the cells	252:368	Electroconductive biocompatible hydrogels with tunable properties have extensively been taken into account in tissue engineering applications due to their potential to provide suitable microenvironmental responses for the cells.
34586146	0	48	theme	electroconductive	34:50	arg1	hydrogels					52:60	electroconductive hydrogels	34:60	electroconductive hydrogels	34:60	Synthesis and characterization of electroconductive hydrogels based on oxidized alginate and polypyrrole-grafted gelatin as tissue scaffolds.
34586146	8	49	theme	movement	1611:1618	arg1	result					1594:1599	a result	1592:1599	a result of easier movement of the ions throughout the hydrogel	1592:1654	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	8	49	theme	movement	1611:1618	arg1	electroconductivity					1569:1587	higher electroconductivity	1562:1587	higher electroconductivity	1562:1587	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	4	50	theme	%	1057:1057	arg1	v/v					1059:1061	 35% v/v	1054:1061	 35% v/v	1054:1061	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	3	51	theme	hydrogels	719:727	arg1	performance					700:710	the compressive modulus and functional performance	661:710	the compressive modulus and functional performance of the hydrogels	661:727	The influence of the composition and the concentration of the components on the compressive modulus and functional performance of the hydrogels is investigated.
34586146	4	52	theme	S	906:906	arg1	m-1					908:910	0.7753 S m-1	899:910	0.7753 S m-1	899:910	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	7	53	theme	cross-link	1408:1417	arg1	density					1419:1425	higher cross-link density	1401:1425	higher cross-link density	1401:1425	Besides, the conductive hydrogels have a smaller mesh size and higher cross-link density than the non-conductive hydrogels.
34586146	1	54	theme	engineering	259:269	arg1	applications					271:282	tissue engineering applications	252:282	tissue engineering applications due to their potential to provide suitable microenvironmental responses for the cells	252:368	Electroconductive biocompatible hydrogels with tunable properties have extensively been taken into account in tissue engineering applications due to their potential to provide suitable microenvironmental responses for the cells.
34586146	8	55	theme	easier	1604:1609	arg1	movement					1611:1618	easier movement	1604:1618	easier movement of the ions throughout the hydrogel	1604:1654	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	0	56	theme	oxidized	71:78	arg1	gelatin					113:119	oxidized alginate and polypyrrole-grafted gelatin	71:119	oxidized alginate and polypyrrole-grafted gelatin as tissue scaffolds	71:139	Synthesis and characterization of electroconductive hydrogels based on oxidized alginate and polypyrrole-grafted gelatin as tissue scaffolds.
34586146	5	57	theme	compressive	1078:1088	arg1	modulus					1090:1096	The hydrogel compressive modulus	1065:1096	The hydrogel compressive modulus	1065:1096	The hydrogel compressive modulus was shown to be enhanced by increasing the total concentration of hydrogel.
34586146	9	58	theme	tissue	1796:1801	arg1	engineering					1803:1813	tissue engineering	1796:1813	tissue engineering	1796:1813	These conductive hydrogels exhibited electrical conductivity and biodegradability with cell viability, implying potential as scaffolds for tissue engineering.
34586146	2	59	theme	novel	393:397	arg1	hydrogels					417:425	novel electroconductive hydrogels	393:425	novel electroconductive hydrogels	393:425	In the present study, novel electroconductive hydrogels are designed and synthesized by reacting oxidized alginate with polypyrrole-grafted gelatin copolymer (PPy-g-gelatin) via formation of a Schiff-base linkage.
34586146	7	60	contain	have	1372:1375	arg1	hydrogels					1362:1370	the conductive hydrogels	1347:1370	the conductive hydrogels	1347:1370	Besides, the conductive hydrogels have a smaller mesh size and higher cross-link density than the non-conductive hydrogels.
34586146	7	60	contain	have	1372:1375	arg2	density					1419:1425	higher cross-link density	1401:1425	higher cross-link density	1401:1425	Besides, the conductive hydrogels have a smaller mesh size and higher cross-link density than the non-conductive hydrogels.
34586146	7	60	contain	have	1372:1375	arg2	size					1392:1395	a smaller mesh size	1377:1395	a smaller mesh size	1377:1395	Besides, the conductive hydrogels have a smaller mesh size and higher cross-link density than the non-conductive hydrogels.
34586146	6	61	theme	swelling	1239:1246	arg1	ratio					1248:1252	swelling ratio	1239:1252	swelling ratio	1239:1252	The characteristic features of the prepared hydrogels, including swelling ratio, volume fraction, cross-link density, and mesh size, are also studied and analyzed.
34586146	4	62	theme	polypyrrole-grafted	961:979	arg1	gelatin					981:987	8% w/v polypyrrole-grafted gelatin	954:987	8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v)	954:1062	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	4	62	theme	polypyrrole-grafted	961:979	arg1	alginate					999:1006	oxidized alginate	990:1006	oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 	990:1052	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	8	63	theme	small	1515:1519	arg1	size					1526:1529	small mesh size	1515:1529	small mesh size	1515:1529	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	3	64	theme	compressive	665:675	arg1	performance					700:710	the compressive modulus and functional performance	661:710	the compressive modulus and functional performance of the hydrogels	661:727	The influence of the composition and the concentration of the components on the compressive modulus and functional performance of the hydrogels is investigated.
34586146	1	65	theme	Electroconductive	142:158	arg1	hydrogels					174:182	Electroconductive biocompatible hydrogels	142:182	Electroconductive biocompatible hydrogels with tunable properties	142:206	Electroconductive biocompatible hydrogels with tunable properties have extensively been taken into account in tissue engineering applications due to their potential to provide suitable microenvironmental responses for the cells.
34586146	4	66	theme	oxidized	990:997	arg1	gelatin					981:987	8% w/v polypyrrole-grafted gelatin	954:987	8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v)	954:1062	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	4	66	theme	oxidized	990:997	arg1	alginate					999:1006	oxidized alginate	990:1006	oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 	990:1052	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	4	67	theme	hydrogels	770:778	arg1	conductivity					750:761	The conductivity	746:761	The conductivity of the hydrogels measured by a two-probe method	746:809	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	1	68	theme	biocompatible	160:172	arg1	hydrogels					174:182	Electroconductive biocompatible hydrogels	142:182	Electroconductive biocompatible hydrogels with tunable properties	142:206	Electroconductive biocompatible hydrogels with tunable properties have extensively been taken into account in tissue engineering applications due to their potential to provide suitable microenvironmental responses for the cells.
34586146	9	69	theme	conductive	1663:1672	arg1	hydrogels					1674:1682	These conductive hydrogels	1657:1682	These conductive hydrogels	1657:1682	These conductive hydrogels exhibited electrical conductivity and biodegradability with cell viability, implying potential as scaffolds for tissue engineering.
34586146	2	70	theme	present	378:384	arg1	study					386:390	the present study	374:390	the present study	374:390	In the present study, novel electroconductive hydrogels are designed and synthesized by reacting oxidized alginate with polypyrrole-grafted gelatin copolymer (PPy-g-gelatin) via formation of a Schiff-base linkage.
34586146	4	71	theme	%	955:955	arg1	gelatin					981:987	8% w/v polypyrrole-grafted gelatin	954:987	8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v)	954:1062	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	4	71	theme	%	955:955	arg1	alginate					999:1006	oxidized alginate	990:1006	oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 	990:1052	The conductivity of the hydrogels measured by a two-probe method increased by increasing the level of polypyrrole-grafted gelatin, and a conductivity of 0.7753 S m-1 was exhibited by the hydrogel composed of 8% w/v polypyrrole-grafted gelatin (oxidized alginate:gelatin:polypyrrole-grafted gelatin; 30 : 35 : 35% v/v).
34586146	1	72	theme	due	284:286	arg1	applications					271:282	tissue engineering applications	252:282	tissue engineering applications due to their potential to provide suitable microenvironmental responses for the cells	252:368	Electroconductive biocompatible hydrogels with tunable properties have extensively been taken into account in tissue engineering applications due to their potential to provide suitable microenvironmental responses for the cells.
34586146	0	73	theme	alginate	80:87	arg1	gelatin					113:119	oxidized alginate and polypyrrole-grafted gelatin	71:119	oxidized alginate and polypyrrole-grafted gelatin as tissue scaffolds	71:139	Synthesis and characterization of electroconductive hydrogels based on oxidized alginate and polypyrrole-grafted gelatin as tissue scaffolds.
34586146	2	74	theme	oxidized	468:475	arg1	alginate					477:484	oxidized alginate	468:484	oxidized alginate with polypyrrole-grafted gelatin copolymer (PPy-g-gelatin)	468:543	In the present study, novel electroconductive hydrogels are designed and synthesized by reacting oxidized alginate with polypyrrole-grafted gelatin copolymer (PPy-g-gelatin) via formation of a Schiff-base linkage.
34586146	3	75	theme	functional	689:698	arg1	performance					700:710	the compressive modulus and functional performance	661:710	the compressive modulus and functional performance of the hydrogels	661:727	The influence of the composition and the concentration of the components on the compressive modulus and functional performance of the hydrogels is investigated.
34586146	2	76	theme	linkage	576:582	arg1	formation					549:557	formation	549:557	formation of a Schiff-base linkage	549:582	In the present study, novel electroconductive hydrogels are designed and synthesized by reacting oxidized alginate with polypyrrole-grafted gelatin copolymer (PPy-g-gelatin) via formation of a Schiff-base linkage.
34586146	7	77	theme	mesh	1387:1390	arg1	size					1392:1395	a smaller mesh size	1377:1395	a smaller mesh size	1377:1395	Besides, the conductive hydrogels have a smaller mesh size and higher cross-link density than the non-conductive hydrogels.
34586146	8	78	with	hydrogels	1475:1483	arg1	density					1506:1512	high cross-link density	1490:1512	high cross-link density	1490:1512	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	8	78	with	hydrogels	1475:1483	arg1	size					1547:1550	large pore size	1536:1550	large pore size	1536:1550	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	8	78	with	hydrogels	1475:1483	arg1	size					1526:1529	small mesh size	1515:1529	small mesh size	1515:1529	However, the hydrogels with high cross-link density, small mesh size, and large pore size presented higher electroconductivity as a result of easier movement of the ions throughout the hydrogel.
34586146	1	79	theme	tunable	189:195	arg1	properties					197:206	tunable properties	189:206	tunable properties	189:206	Electroconductive biocompatible hydrogels with tunable properties have extensively been taken into account in tissue engineering applications due to their potential to provide suitable microenvironmental responses for the cells.
33630897	1	0	theme	bioactive	256:264	arg1	cargo					266:270	sensitive bioactive cargo	246:270	sensitive bioactive cargo	246:270	Alginates gel rapidly under ambient conditions and have widely documented potential to form protective matrices for sensitive bioactive cargo.
33630897	7	1	theme	target	1105:1110	arg1	crosslinking					1112:1123	target crosslinking	1105:1123	target crosslinking	1105:1123	To understand how to select alginates to target crosslinking in CLAMs, we examined the roles of alginate molecular properties.
33630897	10	2	theme	alginates	1664:1672	arg1	weights					1649:1655	the molecular weights	1635:1655	the molecular weights of the alginates at saturating calcium concentrations	1635:1709	The 'extent of gelation' of spray dried CLAMs is influenced by the molecular weights of the alginates at saturating calcium concentrations.
33630897	9	3	theme	CLAMs	1398:1402	arg1	gelation					1404:1411	spray dried CLAMs gelation	1386:1411	spray dried CLAMs gelation	1386:1411	Thus, spray dried CLAMs gelation is due to calcium crosslinking and alginic acid formation, and unlike external gelation methods, is insensitive to the molecular composition of the alginates.
33630897	10	4	from	weights	1649:1655	arg1	concentrations					1696:1709	saturating calcium concentrations	1677:1709	saturating calcium concentrations	1677:1709	The 'extent of gelation' of spray dried CLAMs is influenced by the molecular weights of the alginates at saturating calcium concentrations.
33630897	10	5	theme	calcium	1688:1694	arg1	concentrations					1696:1709	saturating calcium concentrations	1677:1709	saturating calcium concentrations	1677:1709	The 'extent of gelation' of spray dried CLAMs is influenced by the molecular weights of the alginates at saturating calcium concentrations.
33630897	4	6	from	extent	658:663	arg1	CLAMs					697:701	CLAMs	697:701	CLAMs	697:701	The extent of crosslinking of alginates in CLAMs impacts the effectiveness of its barrier properties.
33630897	4	7	theme	crosslinking	668:679	arg1	extent					658:663	The extent	654:663	The extent of crosslinking of alginates in CLAMs	654:701	The extent of crosslinking of alginates in CLAMs impacts the effectiveness of its barrier properties.
33630897	6	8	from	Crosslinking	876:887	arg1	CLAMs					892:896	CLAMs	892:896	CLAMs	892:896	Crosslinking in CLAMs can be controlled by varying the calcium to alginate ratio; however, the choice of alginates used in the process also influences the ultimate extent of crosslinking.
33630897	1	9	theme	documented	193:202	arg1	potential					204:212	widely documented potential	186:212	widely documented potential to form protective matrices for sensitive bioactive cargo	186:270	Alginates gel rapidly under ambient conditions and have widely documented potential to form protective matrices for sensitive bioactive cargo.
33630897	11	10	theme	gelation	1852:1859	arg1	extent					1861:1866	target gelation extent	1845:1866	target gelation extent in CLAMs	1845:1875	Alginate viscosity correlates with molecular weight; thus, viscosity is a convenient criterion for selecting commercial alginates to target gelation extent in CLAMs.
33630897	9	11	theme	spray	1386:1390	arg1	gelation					1404:1411	spray dried CLAMs gelation	1386:1411	spray dried CLAMs gelation	1386:1411	Thus, spray dried CLAMs gelation is due to calcium crosslinking and alginic acid formation, and unlike external gelation methods, is insensitive to the molecular composition of the alginates.
33630897	3	12	theme	bioactives	606:615	arg1	protection					568:577	protection	568:577	protection	568:577	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	12	theme	bioactives	606:615	arg1	delivery					594:601	controlled delivery	583:601	controlled delivery of bioactives in food, cosmetics, and agriculture	583:651	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	5	13	theme	encapsulated	856:867	arg1	cargo					869:873	the encapsulated cargo	852:873	the encapsulated cargo	852:873	For example, higher crosslinking extents can improve oxidative stability and limit diffusion of the encapsulated cargo.
33630897	6	14	dep	ratio	951:955	arg1	to					939:940	to	939:940	to	939:940	Crosslinking in CLAMs can be controlled by varying the calcium to alginate ratio; however, the choice of alginates used in the process also influences the ultimate extent of crosslinking.
33630897	3	15	link	crosslinked	434:444	arg1	CLAMs					470:474	CLAMs	470:474	CLAMs	470:474	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	15	link	crosslinked	434:444	arg1	microcapsules					455:467	crosslinked alginate microcapsules	434:467	crosslinked alginate microcapsules (CLAMs)	434:475	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	10	16	from	concentrations	1696:1709	arg1	weights					1649:1655	the molecular weights	1635:1655	the molecular weights of the alginates at saturating calcium concentrations	1635:1709	The 'extent of gelation' of spray dried CLAMs is influenced by the molecular weights of the alginates at saturating calcium concentrations.
33630897	10	16	from	concentrations	1696:1709	arg1	alginates					1664:1672	the alginates	1660:1672	the alginates at saturating calcium concentrations	1660:1709	The 'extent of gelation' of spray dried CLAMs is influenced by the molecular weights of the alginates at saturating calcium concentrations.
33630897	4	17	theme	alginates	684:692	arg1	crosslinking					668:679	crosslinking	668:679	crosslinking of alginates	668:692	The extent of crosslinking of alginates in CLAMs impacts the effectiveness of its barrier properties.
33630897	9	18	theme	external	1483:1490	arg1	methods					1501:1507	external gelation methods	1483:1507	external gelation methods	1483:1507	Thus, spray dried CLAMs gelation is due to calcium crosslinking and alginic acid formation, and unlike external gelation methods, is insensitive to the molecular composition of the alginates.
33630897	8	19	theme	rapid	1307:1311	arg1	reduction					1316:1324	simultaneous and rapid pH reduction	1290:1324	simultaneous and rapid pH reduction	1290:1324	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	0	20	theme	alginate	75:82	arg1	CLAMs					99:103	CLAMs	99:103	CLAMs	99:103	How alginate properties influence in situ internal gelation in crosslinked alginate microcapsules (CLAMs) formed by spray drying.
33630897	0	20	theme	alginate	75:82	arg1	microcapsules					84:96	crosslinked alginate microcapsules	63:96	crosslinked alginate microcapsules (CLAMs) formed by spray drying	63:127	How alginate properties influence in situ internal gelation in crosslinked alginate microcapsules (CLAMs) formed by spray drying.
33630897	8	21	theme	reduction	1316:1324	arg1	consequence					1275:1285	a consequence	1273:1285	a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying	1273:1377	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	8	21	theme	reduction	1316:1324	arg1	CLAMs					1259:1263	the CLAMs	1255:1263	the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying	1255:1377	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	3	22	dep	breakthrough	413:424	arg1	form					429:432	form	429:432	to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process")	426:533	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	8	23	theme	moisture	1330:1337	arg1	removal					1339:1345	moisture removal	1330:1345	moisture removal	1330:1345	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	3	24	from	food	620:623	arg1	protection					568:577	protection	568:577	protection	568:577	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	24	from	food	620:623	arg1	delivery					594:601	controlled delivery	583:601	controlled delivery of bioactives in food, cosmetics, and agriculture	583:651	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	10	25	theme	dried	1606:1610	arg1	CLAMs					1612:1616	spray dried CLAMs	1600:1616	spray dried CLAMs	1600:1616	The 'extent of gelation' of spray dried CLAMs is influenced by the molecular weights of the alginates at saturating calcium concentrations.
33630897	7	26	theme	properties	1179:1188	arg1	roles					1151:1155	the roles	1147:1155	the roles of alginate molecular properties	1147:1188	To understand how to select alginates to target crosslinking in CLAMs, we examined the roles of alginate molecular properties.
33630897	11	27	theme	Alginate	1712:1719	arg1	viscosity					1721:1729	Alginate viscosity	1712:1729	Alginate viscosity	1712:1729	Alginate viscosity correlates with molecular weight; thus, viscosity is a convenient criterion for selecting commercial alginates to target gelation extent in CLAMs.
33630897	4	28	theme	barrier	736:742	arg1	properties					744:753	its barrier properties	732:753	its barrier properties	732:753	The extent of crosslinking of alginates in CLAMs impacts the effectiveness of its barrier properties.
33630897	3	29	from	cosmetics	626:634	arg1	protection					568:577	protection	568:577	protection	568:577	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	29	from	cosmetics	626:634	arg1	delivery					594:601	controlled delivery	583:601	controlled delivery of bioactives in food, cosmetics, and agriculture	583:651	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	30	theme	alginate	446:453	arg1	CLAMs					470:474	CLAMs	470:474	CLAMs	470:474	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	30	theme	alginate	446:453	arg1	microcapsules					455:467	crosslinked alginate microcapsules	434:467	crosslinked alginate microcapsules (CLAMs)	434:475	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	7	31	theme	alginate	1160:1167	arg1	properties					1179:1188	alginate molecular properties	1160:1188	alginate molecular properties	1160:1188	To understand how to select alginates to target crosslinking in CLAMs, we examined the roles of alginate molecular properties.
33630897	9	32	theme	molecular	1532:1540	arg1	composition					1542:1552	the molecular composition	1528:1552	the molecular composition of the alginates	1528:1569	Thus, spray dried CLAMs gelation is due to calcium crosslinking and alginic acid formation, and unlike external gelation methods, is insensitive to the molecular composition of the alginates.
33630897	6	33	theme	crosslinking	1050:1061	arg1	extent					1040:1045	the ultimate extent	1027:1045	the ultimate extent of crosslinking	1027:1061	Crosslinking in CLAMs can be controlled by varying the calcium to alginate ratio; however, the choice of alginates used in the process also influences the ultimate extent of crosslinking.
33630897	3	34	from	delivery	594:601	arg1	agriculture					641:651	agriculture	641:651	agriculture	641:651	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	34	from	delivery	594:601	arg1	food					620:623	food	620:623	food	620:623	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	34	from	delivery	594:601	arg1	cosmetics					626:634	cosmetics	626:634	cosmetics	626:634	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	35	theme	in	480:481	arg1	gelation					488:495	in situ gelation	480:495	in situ gelation during spray drying ("CLAMs process")	480:533	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	10	36	theme	saturating	1677:1686	arg1	concentrations					1696:1709	saturating calcium concentrations	1677:1709	saturating calcium concentrations	1677:1709	The 'extent of gelation' of spray dried CLAMs is influenced by the molecular weights of the alginates at saturating calcium concentrations.
33630897	8	37	theme	simultaneous	1290:1301	arg1	reduction					1316:1324	simultaneous and rapid pH reduction	1290:1324	simultaneous and rapid pH reduction	1290:1324	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	7	38	from	alginates	1092:1100	arg1	CLAMs					1128:1132	CLAMs	1128:1132	CLAMs	1128:1132	To understand how to select alginates to target crosslinking in CLAMs, we examined the roles of alginate molecular properties.
33630897	3	39	from	bioactives	606:615	arg1	agriculture					641:651	agriculture	641:651	agriculture	641:651	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	39	from	bioactives	606:615	arg1	food					620:623	food	620:623	food	620:623	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	39	from	bioactives	606:615	arg1	cosmetics					626:634	cosmetics	626:634	cosmetics	626:634	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	1	40	theme	ambient	158:164	arg1	conditions					166:175	ambient conditions	158:175	ambient conditions	158:175	Alginates gel rapidly under ambient conditions and have widely documented potential to form protective matrices for sensitive bioactive cargo.
33630897	0	41	theme	in	34:35	arg1	gelation					51:58	in situ internal gelation	34:58	in situ internal gelation	34:58	How alginate properties influence in situ internal gelation in crosslinked alginate microcapsules (CLAMs) formed by spray drying.
33630897	9	42	theme	alginates	1561:1569	arg1	composition					1542:1552	the molecular composition	1528:1552	the molecular composition of the alginates	1528:1569	Thus, spray dried CLAMs gelation is due to calcium crosslinking and alginic acid formation, and unlike external gelation methods, is insensitive to the molecular composition of the alginates.
33630897	3	43	theme	spray	504:508	arg1	"					532:532	"CLAMs process"	518:532	"CLAMs process"	518:532	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	43	theme	spray	504:508	arg1	drying					510:515	spray drying	504:515	spray drying ("CLAMs process")	504:533	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	0	44	theme	internal	42:49	arg1	gelation					51:58	in situ internal gelation	34:58	in situ internal gelation	34:58	How alginate properties influence in situ internal gelation in crosslinked alginate microcapsules (CLAMs) formed by spray drying.
33630897	0	45	dep	in	34:35	arg1	situ					37:40	situ	37:40	situ	37:40	How alginate properties influence in situ internal gelation in crosslinked alginate microcapsules (CLAMs) formed by spray drying.
33630897	0	46	link	crosslinked	63:73	arg1	CLAMs					99:103	CLAMs	99:103	CLAMs	99:103	How alginate properties influence in situ internal gelation in crosslinked alginate microcapsules (CLAMs) formed by spray drying.
33630897	0	46	link	crosslinked	63:73	arg1	microcapsules					84:96	crosslinked alginate microcapsules	63:96	crosslinked alginate microcapsules (CLAMs) formed by spray drying	63:127	How alginate properties influence in situ internal gelation in crosslinked alginate microcapsules (CLAMs) formed by spray drying.
33630897	2	47	theme	electrostatic	334:346	arg1	crosslinks					348:357	calcium mediated electrostatic crosslinks	317:357	calcium mediated electrostatic crosslinks between the linear polyuronic acid polymers	317:401	Most commonly, alginate gelation occurs via calcium mediated electrostatic crosslinks between the linear polyuronic acid polymers.
33630897	3	48	theme	CLAMs	519:523	arg1	"					532:532	"CLAMs process"	518:532	"CLAMs process"	518:532	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	48	theme	CLAMs	519:523	arg1	drying					510:515	spray drying	504:515	spray drying ("CLAMs process")	504:533	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	6	49	theme	calcium	931:937	arg1	ratio					951:955	the calcium to alginate ratio	927:955	the calcium to alginate ratio	927:955	Crosslinking in CLAMs can be controlled by varying the calcium to alginate ratio; however, the choice of alginates used in the process also influences the ultimate extent of crosslinking.
33630897	2	50	theme	linear	371:376	arg1	polymers					394:401	the linear polyuronic acid polymers	367:401	the linear polyuronic acid polymers	367:401	Most commonly, alginate gelation occurs via calcium mediated electrostatic crosslinks between the linear polyuronic acid polymers.
33630897	1	51	theme	sensitive	246:254	arg1	cargo					266:270	sensitive bioactive cargo	246:270	sensitive bioactive cargo	246:270	Alginates gel rapidly under ambient conditions and have widely documented potential to form protective matrices for sensitive bioactive cargo.
33630897	2	52	theme	alginate	288:295	arg1	gelation					297:304	alginate gelation	288:304	alginate gelation	288:304	Most commonly, alginate gelation occurs via calcium mediated electrostatic crosslinks between the linear polyuronic acid polymers.
33630897	9	53	theme	dried	1392:1396	arg1	gelation					1404:1411	spray dried CLAMs gelation	1386:1411	spray dried CLAMs gelation	1386:1411	Thus, spray dried CLAMs gelation is due to calcium crosslinking and alginic acid formation, and unlike external gelation methods, is insensitive to the molecular composition of the alginates.
33630897	3	54	from	agriculture	641:651	arg1	protection					568:577	protection	568:577	protection	568:577	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	54	from	agriculture	641:651	arg1	delivery					594:601	controlled delivery	583:601	controlled delivery of bioactives in food, cosmetics, and agriculture	583:651	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	8	55	theme	acid	1239:1242	arg1	gelling					1244:1250	alginic acid gelling	1231:1250	alginic acid gelling	1231:1250	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	5	56	theme	cargo	869:873	arg1	diffusion					839:847	diffusion	839:847	diffusion of the encapsulated cargo	839:873	For example, higher crosslinking extents can improve oxidative stability and limit diffusion of the encapsulated cargo.
33630897	5	57	theme	higher	769:774	arg1	extents					789:795	higher crosslinking extents	769:795	higher crosslinking extents	769:795	For example, higher crosslinking extents can improve oxidative stability and limit diffusion of the encapsulated cargo.
33630897	8	58	theme	alginic	1231:1237	arg1	gelling					1244:1250	alginic acid gelling	1231:1250	alginic acid gelling	1231:1250	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	0	59	theme	spray	116:120	arg1	drying					122:127	spray drying	116:127	spray drying	116:127	How alginate properties influence in situ internal gelation in crosslinked alginate microcapsules (CLAMs) formed by spray drying.
33630897	9	60	theme	calcium	1423:1429	arg1	crosslinking					1431:1442	calcium crosslinking	1423:1442	calcium crosslinking	1423:1442	Thus, spray dried CLAMs gelation is due to calcium crosslinking and alginic acid formation, and unlike external gelation methods, is insensitive to the molecular composition of the alginates.
33630897	8	61	theme	gelling	1244:1250	arg1	finding					1202:1208	A surprise finding	1191:1208	A surprise finding	1191:1208	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	8	61	theme	gelling	1244:1250	arg1	formation					1218:1226	the formation	1214:1226	the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying	1214:1377	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	8	62	theme	surprise	1193:1200	arg1	finding					1202:1208	A surprise finding	1191:1208	A surprise finding	1191:1208	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	8	62	theme	surprise	1193:1200	arg1	formation					1218:1226	the formation	1214:1226	the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying	1214:1377	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	11	63	theme	convenient	1786:1795	arg1	criterion					1797:1805	a convenient criterion	1784:1805	a convenient criterion for selecting commercial alginates to target gelation extent in CLAMs	1784:1875	Alginate viscosity correlates with molecular weight; thus, viscosity is a convenient criterion for selecting commercial alginates to target gelation extent in CLAMs.
33630897	11	63	theme	convenient	1786:1795	arg1	viscosity					1771:1779	viscosity	1771:1779	viscosity	1771:1779	Alginate viscosity correlates with molecular weight; thus, viscosity is a convenient criterion for selecting commercial alginates to target gelation extent in CLAMs.
33630897	3	64	theme	controlled	583:592	arg1	delivery					594:601	controlled delivery	583:601	controlled delivery of bioactives in food, cosmetics, and agriculture	583:651	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	9	65	theme	acid	1456:1459	arg1	formation					1461:1469	alginic acid formation	1448:1469	alginic acid formation	1448:1469	Thus, spray dried CLAMs gelation is due to calcium crosslinking and alginic acid formation, and unlike external gelation methods, is insensitive to the molecular composition of the alginates.
33630897	6	66	theme	alginate	942:949	arg1	ratio					951:955	the calcium to alginate ratio	927:955	the calcium to alginate ratio	927:955	Crosslinking in CLAMs can be controlled by varying the calcium to alginate ratio; however, the choice of alginates used in the process also influences the ultimate extent of crosslinking.
33630897	3	67	from	applications	552:563	arg1	protection					568:577	protection	568:577	protection	568:577	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	67	from	applications	552:563	arg1	delivery					594:601	controlled delivery	583:601	controlled delivery of bioactives in food, cosmetics, and agriculture	583:651	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	8	68	from	formation	1218:1226	arg1	consequence					1275:1285	a consequence	1273:1285	a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying	1273:1377	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	8	68	from	formation	1218:1226	arg1	CLAMs					1259:1263	the CLAMs	1255:1263	the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying	1255:1377	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	11	69	from	extent	1861:1866	arg1	CLAMs					1871:1875	CLAMs	1871:1875	CLAMs	1871:1875	Alginate viscosity correlates with molecular weight; thus, viscosity is a convenient criterion for selecting commercial alginates to target gelation extent in CLAMs.
33630897	3	70	from	protection	568:577	arg1	agriculture					641:651	agriculture	641:651	agriculture	641:651	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	70	from	protection	568:577	arg1	food					620:623	food	620:623	food	620:623	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	70	from	protection	568:577	arg1	cosmetics					626:634	cosmetics	626:634	cosmetics	626:634	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	10	71	theme	molecular	1639:1647	arg1	weights					1649:1655	the molecular weights	1635:1655	the molecular weights of the alginates at saturating calcium concentrations	1635:1709	The 'extent of gelation' of spray dried CLAMs is influenced by the molecular weights of the alginates at saturating calcium concentrations.
33630897	0	72	theme	crosslinked	63:73	arg1	CLAMs					99:103	CLAMs	99:103	CLAMs	99:103	How alginate properties influence in situ internal gelation in crosslinked alginate microcapsules (CLAMs) formed by spray drying.
33630897	0	72	theme	crosslinked	63:73	arg1	microcapsules					84:96	crosslinked alginate microcapsules	63:96	crosslinked alginate microcapsules (CLAMs) formed by spray drying	63:127	How alginate properties influence in situ internal gelation in crosslinked alginate microcapsules (CLAMs) formed by spray drying.
33630897	9	73	theme	gelation	1492:1499	arg1	methods					1501:1507	external gelation methods	1483:1507	external gelation methods	1483:1507	Thus, spray dried CLAMs gelation is due to calcium crosslinking and alginic acid formation, and unlike external gelation methods, is insensitive to the molecular composition of the alginates.
33630897	11	74	theme	molecular	1747:1755	arg1	weight					1757:1762	molecular weight	1747:1762	molecular weight	1747:1762	Alginate viscosity correlates with molecular weight; thus, viscosity is a convenient criterion for selecting commercial alginates to target gelation extent in CLAMs.
33630897	6	75	theme	alginates	981:989	arg1	choice					971:976	the choice	967:976	the choice of alginates used in the process	967:1009	Crosslinking in CLAMs can be controlled by varying the calcium to alginate ratio; however, the choice of alginates used in the process also influences the ultimate extent of crosslinking.
33630897	8	76	theme	pH	1313:1314	arg1	reduction					1316:1324	simultaneous and rapid pH reduction	1290:1324	simultaneous and rapid pH reduction	1290:1324	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	2	77	theme	mediated	325:332	arg1	crosslinks					348:357	calcium mediated electrostatic crosslinks	317:357	calcium mediated electrostatic crosslinks between the linear polyuronic acid polymers	317:401	Most commonly, alginate gelation occurs via calcium mediated electrostatic crosslinks between the linear polyuronic acid polymers.
33630897	7	78	theme	molecular	1169:1177	arg1	properties					1179:1188	alginate molecular properties	1160:1188	alginate molecular properties	1160:1188	To understand how to select alginates to target crosslinking in CLAMs, we examined the roles of alginate molecular properties.
33630897	10	79	theme	spray	1600:1604	arg1	CLAMs					1612:1616	spray dried CLAMs	1600:1616	spray dried CLAMs	1600:1616	The 'extent of gelation' of spray dried CLAMs is influenced by the molecular weights of the alginates at saturating calcium concentrations.
33630897	5	80	theme	oxidative	809:817	arg1	stability					819:827	oxidative stability	809:827	oxidative stability	809:827	For example, higher crosslinking extents can improve oxidative stability and limit diffusion of the encapsulated cargo.
33630897	3	81	theme	recent	406:411	arg1	breakthrough					413:424	A recent breakthrough	404:424	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process")	404:533	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	8	82	theme	removal	1339:1345	arg1	consequence					1275:1285	a consequence	1273:1285	a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying	1273:1377	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	8	82	theme	removal	1339:1345	arg1	CLAMs					1259:1263	the CLAMs	1255:1263	the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying	1255:1377	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	1	83	contain	have	181:184	arg2	potential					204:212	widely documented potential	186:212	widely documented potential to form protective matrices for sensitive bioactive cargo	186:270	Alginates gel rapidly under ambient conditions and have widely documented potential to form protective matrices for sensitive bioactive cargo.
33630897	1	83	contain	have	181:184	arg1	Alginates					130:138	Alginates	130:138	Alginates	130:138	Alginates gel rapidly under ambient conditions and have widely documented potential to form protective matrices for sensitive bioactive cargo.
33630897	4	84	theme	properties	744:753	arg1	effectiveness					715:727	the effectiveness	711:727	the effectiveness of its barrier properties	711:753	The extent of crosslinking of alginates in CLAMs impacts the effectiveness of its barrier properties.
33630897	2	85	theme	acid	389:392	arg1	polymers					394:401	the linear polyuronic acid polymers	367:401	the linear polyuronic acid polymers	367:401	Most commonly, alginate gelation occurs via calcium mediated electrostatic crosslinks between the linear polyuronic acid polymers.
33630897	5	86	theme	crosslinking	776:787	arg1	extents					789:795	higher crosslinking extents	769:795	higher crosslinking extents	769:795	For example, higher crosslinking extents can improve oxidative stability and limit diffusion of the encapsulated cargo.
33630897	6	87	theme	ultimate	1031:1038	arg1	extent					1040:1045	the ultimate extent	1027:1045	the ultimate extent of crosslinking	1027:1061	Crosslinking in CLAMs can be controlled by varying the calcium to alginate ratio; however, the choice of alginates used in the process also influences the ultimate extent of crosslinking.
33630897	3	88	theme	crosslinked	434:444	arg1	CLAMs					470:474	CLAMs	470:474	CLAMs	470:474	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	88	theme	crosslinked	434:444	arg1	microcapsules					455:467	crosslinked alginate microcapsules	434:467	crosslinked alginate microcapsules (CLAMs)	434:475	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	8	89	theme	spray	1366:1370	arg1	drying					1372:1377	spray drying	1366:1377	spray drying	1366:1377	A surprise finding was the formation of alginic acid gelling in the CLAMs that is a consequence of simultaneous and rapid pH reduction and moisture removal that occurs during spray drying.
33630897	10	90	theme	CLAMs	1612:1616	arg1	gelation					1587:1594	gelation'	1587:1595	gelation' of spray dried CLAMs	1587:1616	The 'extent of gelation' of spray dried CLAMs is influenced by the molecular weights of the alginates at saturating calcium concentrations.
33630897	11	91	theme	target	1845:1850	arg1	extent					1861:1866	target gelation extent	1845:1866	target gelation extent in CLAMs	1845:1875	Alginate viscosity correlates with molecular weight; thus, viscosity is a convenient criterion for selecting commercial alginates to target gelation extent in CLAMs.
33630897	2	92	theme	polyuronic	378:387	arg1	polymers					394:401	the linear polyuronic acid polymers	367:401	the linear polyuronic acid polymers	367:401	Most commonly, alginate gelation occurs via calcium mediated electrostatic crosslinks between the linear polyuronic acid polymers.
33630897	11	93	theme	commercial	1821:1830	arg1	alginates					1832:1840	commercial alginates	1821:1840	commercial alginates	1821:1840	Alginate viscosity correlates with molecular weight; thus, viscosity is a convenient criterion for selecting commercial alginates to target gelation extent in CLAMs.
33630897	3	94	theme	process	525:531	arg1	"					532:532	"CLAMs process"	518:532	"CLAMs process"	518:532	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	3	94	theme	process	525:531	arg1	drying					510:515	spray drying	504:515	spray drying ("CLAMs process")	504:533	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	1	95	theme	protective	222:231	arg1	matrices					233:240	protective matrices	222:240	protective matrices for sensitive bioactive cargo	222:270	Alginates gel rapidly under ambient conditions and have widely documented potential to form protective matrices for sensitive bioactive cargo.
33630897	9	96	theme	alginic	1448:1454	arg1	formation					1461:1469	alginic acid formation	1448:1469	alginic acid formation	1448:1469	Thus, spray dried CLAMs gelation is due to calcium crosslinking and alginic acid formation, and unlike external gelation methods, is insensitive to the molecular composition of the alginates.
33630897	3	97	dep	in	480:481	arg1	situ					483:486	situ	483:486	situ	483:486	A recent breakthrough to form crosslinked alginate microcapsules (CLAMs) by in situ gelation during spray drying ("CLAMs process") has demonstrated applications in protection and controlled delivery of bioactives in food, cosmetics, and agriculture.
33630897	0	98	theme	alginate	4:11	arg1	properties					13:22	alginate properties	4:22	alginate properties	4:22	How alginate properties influence in situ internal gelation in crosslinked alginate microcapsules (CLAMs) formed by spray drying.
33966247	3	0	theme	Hif-1a	623:628	arg1	genes					603:607	the marker genes	592:607	the marker genes of Prox-1 and Hif-1a	592:628	From the real-time qRT-PCR analysis data, we found the marker genes of Prox-1 and Hif-1a were enriched and decreased in an isolated PVs compared to LVs, respectively.
33966247	1	1	theme	Hif-1a	124:129	arg1	expression					99:108	The gene expression	90:108	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs)	90:231	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	3	2	dep	found	586:590	arg1	enriched					635:642	enriched	635:642	were enriched	630:642	From the real-time qRT-PCR analysis data, we found the marker genes of Prox-1 and Hif-1a were enriched and decreased in an isolated PVs compared to LVs, respectively.
33966247	3	2	dep	found	586:590	arg1	decreased					648:656	decreased	648:656	decreased	648:656	From the real-time qRT-PCR analysis data, we found the marker genes of Prox-1 and Hif-1a were enriched and decreased in an isolated PVs compared to LVs, respectively.
33966247	0	3	theme	Lymph	61:65	arg1	Vessels					67:73	Lymph Vessels	61:73	Lymph Vessels of the Rabbit	61:87	Gene Expression of Prox-1 and Hif-1a in Primo Vessels Inside Lymph Vessels of the Rabbit.
33966247	0	4	from	Expression	5:14	arg1	Vessels					46:52	Primo Vessels	40:52	Primo Vessels	40:52	Gene Expression of Prox-1 and Hif-1a in Primo Vessels Inside Lymph Vessels of the Rabbit.
33966247	2	5	theme	library	448:454	arg1	stage					469:473	the library construction stage	444:473	the library construction stage	444:473	RNA-Seq on the passed 10 samples on RNA-QC for two experimental groups with PVs and PVs + LVs proceeded to the library construction stage automatically and analyzed differentially expressed genes (DEGs).
33966247	1	6	theme	quantitative	278:289	arg1	qRT-PCR					318:324	qRT-PCR	318:324	qRT-PCR	318:324	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	1	6	theme	quantitative	278:289	arg1	reaction					308:315	quantitative polymerase chain reaction	278:315	quantitative polymerase chain reaction (qRT-PCR) analysis	278:334	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	1	7	theme	polymerase	291:300	arg1	qRT-PCR					318:324	qRT-PCR	318:324	qRT-PCR	318:324	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	1	7	theme	polymerase	291:300	arg1	reaction					308:315	quantitative polymerase chain reaction	278:315	quantitative polymerase chain reaction (qRT-PCR) analysis	278:334	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	5	8	theme	inflamed	1115:1122	arg1	cells					1146:1150	inflamed lymphatic endothelial cells	1115:1150	inflamed lymphatic endothelial cells expanding the PV within the LV	1115:1181	This finding indicates that high and low levels of Prox-1 and Hif-1a may be involved in the function of PVs and that pathophysiological and physiological condition could progress into inflamed lymphatic endothelial cells expanding the PV within the LV.
33966247	1	9	theme	chain	302:306	arg1	qRT-PCR					318:324	qRT-PCR	318:324	qRT-PCR	318:324	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	1	9	theme	chain	302:306	arg1	reaction					308:315	quantitative polymerase chain reaction	278:315	quantitative polymerase chain reaction (qRT-PCR) analysis	278:334	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	0	10	theme	Rabbit	82:87	arg1	Vessels					67:73	Lymph Vessels	61:73	Lymph Vessels of the Rabbit	61:87	Gene Expression of Prox-1 and Hif-1a in Primo Vessels Inside Lymph Vessels of the Rabbit.
33966247	1	11	theme	reaction	308:315	arg1	analysis					327:334	quantitative polymerase chain reaction (qRT-PCR) analysis	278:334	quantitative polymerase chain reaction (qRT-PCR) analysis	278:334	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	5	12	theme	endothelial	1134:1144	arg1	cells					1146:1150	inflamed lymphatic endothelial cells	1115:1150	inflamed lymphatic endothelial cells expanding the PV within the LV	1115:1181	This finding indicates that high and low levels of Prox-1 and Hif-1a may be involved in the function of PVs and that pathophysiological and physiological condition could progress into inflamed lymphatic endothelial cells expanding the PV within the LV.
33966247	1	13	theme	isolated	139:146	arg1	PVs					163:165	PVs	163:165	PVs	163:165	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	1	13	theme	isolated	139:146	arg1	vessels					154:160	the isolated primo vessels	135:160	the isolated primo vessels (PVs)	135:166	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	1	13	theme	isolated	139:146	arg1	LVs					201:203	LVs	201:203	LVs	201:203	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	4	14	theme	electric	889:896	arg1	AES					911:913	AES	911:913	AES	911:913	Based on mRNA transcriptional data, Prox-1 and Hif-1a were increased and decreased in PVs compared to LVs + PVs under lipopolysaccharide (LPS) treatment and relieved by acupuncture electric stimulation (AES), respectively.
33966247	4	14	theme	electric	889:896	arg1	stimulation					898:908	acupuncture electric stimulation	877:908	acupuncture electric stimulation (AES)	877:914	Based on mRNA transcriptional data, Prox-1 and Hif-1a were increased and decreased in PVs compared to LVs + PVs under lipopolysaccharide (LPS) treatment and relieved by acupuncture electric stimulation (AES), respectively.
33966247	5	15	theme	pathophysiological	1048:1065	arg1	condition					1085:1093	pathophysiological and physiological condition	1048:1093	pathophysiological and physiological condition	1048:1093	This finding indicates that high and low levels of Prox-1 and Hif-1a may be involved in the function of PVs and that pathophysiological and physiological condition could progress into inflamed lymphatic endothelial cells expanding the PV within the LV.
33966247	5	16	theme	Hif-1a	993:998	arg1	levels					972:977	high and low levels	959:977	high and low levels of Prox-1 and Hif-1a	959:998	This finding indicates that high and low levels of Prox-1 and Hif-1a may be involved in the function of PVs and that pathophysiological and physiological condition could progress into inflamed lymphatic endothelial cells expanding the PV within the LV.
33966247	1	17	theme	primo	148:152	arg1	PVs					163:165	PVs	163:165	PVs	163:165	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	1	17	theme	primo	148:152	arg1	vessels					154:160	the isolated primo vessels	135:160	the isolated primo vessels (PVs)	135:166	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	1	17	theme	primo	148:152	arg1	LVs					201:203	LVs	201:203	LVs	201:203	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	0	18	theme	Gene	0:3	arg1	Expression					5:14	Gene Expression	0:14	Gene Expression of Prox-1 and Hif-1a in Primo Vessels	0:52	Gene Expression of Prox-1 and Hif-1a in Primo Vessels Inside Lymph Vessels of the Rabbit.
33966247	3	19	theme	isolated	664:671	arg1	PVs					673:675	an isolated PVs	661:675	an isolated PVs	661:675	From the real-time qRT-PCR analysis data, we found the marker genes of Prox-1 and Hif-1a were enriched and decreased in an isolated PVs compared to LVs, respectively.
33966247	0	20	theme	Prox-1	19:24	arg1	Expression					5:14	Gene Expression	0:14	Gene Expression of Prox-1 and Hif-1a in Primo Vessels	0:52	Gene Expression of Prox-1 and Hif-1a in Primo Vessels Inside Lymph Vessels of the Rabbit.
33966247	4	21	theme	lipopolysaccharide	826:843	arg1	treatment					851:859	lipopolysaccharide (LPS) treatment	826:859	lipopolysaccharide (LPS) treatment	826:859	Based on mRNA transcriptional data, Prox-1 and Hif-1a were increased and decreased in PVs compared to LVs + PVs under lipopolysaccharide (LPS) treatment and relieved by acupuncture electric stimulation (AES), respectively.
33966247	2	22	theme	passed	352:357	arg1	samples					362:368	the passed 10 samples	348:368	the passed 10 samples	348:368	RNA-Seq on the passed 10 samples on RNA-QC for two experimental groups with PVs and PVs + LVs proceeded to the library construction stage automatically and analyzed differentially expressed genes (DEGs).
33966247	5	23	theme	physiological	1071:1083	arg1	condition					1085:1093	pathophysiological and physiological condition	1048:1093	pathophysiological and physiological condition	1048:1093	This finding indicates that high and low levels of Prox-1 and Hif-1a may be involved in the function of PVs and that pathophysiological and physiological condition could progress into inflamed lymphatic endothelial cells expanding the PV within the LV.
33966247	5	24	theme	low	968:970	arg1	levels					972:977	high and low levels	959:977	high and low levels of Prox-1 and Hif-1a	959:998	This finding indicates that high and low levels of Prox-1 and Hif-1a may be involved in the function of PVs and that pathophysiological and physiological condition could progress into inflamed lymphatic endothelial cells expanding the PV within the LV.
33966247	0	25	theme	Hif-1a	30:35	arg1	Expression					5:14	Gene Expression	0:14	Gene Expression of Prox-1 and Hif-1a in Primo Vessels	0:52	Gene Expression of Prox-1 and Hif-1a in Primo Vessels Inside Lymph Vessels of the Rabbit.
33966247	4	26	theme	transcriptional	722:736	arg1	data					738:741	mRNA transcriptional data	717:741	mRNA transcriptional data	717:741	Based on mRNA transcriptional data, Prox-1 and Hif-1a were increased and decreased in PVs compared to LVs + PVs under lipopolysaccharide (LPS) treatment and relieved by acupuncture electric stimulation (AES), respectively.
33966247	2	27	theme	experimental	388:399	arg1	groups					401:406	two experimental groups	384:406	two experimental groups with PVs and PVs + LVs	384:429	RNA-Seq on the passed 10 samples on RNA-QC for two experimental groups with PVs and PVs + LVs proceeded to the library construction stage automatically and analyzed differentially expressed genes (DEGs).
33966247	2	28	theme	construction	456:467	arg1	stage					469:473	the library construction stage	444:473	the library construction stage	444:473	RNA-Seq on the passed 10 samples on RNA-QC for two experimental groups with PVs and PVs + LVs proceeded to the library construction stage automatically and analyzed differentially expressed genes (DEGs).
33966247	3	29	theme	analysis	568:575	arg1	data					577:580	the real-time qRT-PCR analysis data	546:580	the real-time qRT-PCR analysis data	546:580	From the real-time qRT-PCR analysis data, we found the marker genes of Prox-1 and Hif-1a were enriched and decreased in an isolated PVs compared to LVs, respectively.
33966247	4	30	theme	mRNA	717:720	arg1	data					738:741	mRNA transcriptional data	717:741	mRNA transcriptional data	717:741	Based on mRNA transcriptional data, Prox-1 and Hif-1a were increased and decreased in PVs compared to LVs + PVs under lipopolysaccharide (LPS) treatment and relieved by acupuncture electric stimulation (AES), respectively.
33966247	0	31	theme	Primo	40:44	arg1	Vessels					46:52	Primo Vessels	40:52	Primo Vessels	40:52	Gene Expression of Prox-1 and Hif-1a in Primo Vessels Inside Lymph Vessels of the Rabbit.
33966247	5	32	theme	PVs	1035:1037	arg1	function					1023:1030	the function	1019:1030	the function of PVs	1019:1037	This finding indicates that high and low levels of Prox-1 and Hif-1a may be involved in the function of PVs and that pathophysiological and physiological condition could progress into inflamed lymphatic endothelial cells expanding the PV within the LV.
33966247	5	33	theme	Prox-1	982:987	arg1	levels					972:977	high and low levels	959:977	high and low levels of Prox-1 and Hif-1a	959:998	This finding indicates that high and low levels of Prox-1 and Hif-1a may be involved in the function of PVs and that pathophysiological and physiological condition could progress into inflamed lymphatic endothelial cells expanding the PV within the LV.
33966247	3	34	theme	qRT-PCR	560:566	arg1	data					577:580	the real-time qRT-PCR analysis data	546:580	the real-time qRT-PCR analysis data	546:580	From the real-time qRT-PCR analysis data, we found the marker genes of Prox-1 and Hif-1a were enriched and decreased in an isolated PVs compared to LVs, respectively.
33966247	3	35	theme	Prox-1	612:617	arg1	genes					603:607	the marker genes	592:607	the marker genes of Prox-1 and Hif-1a	592:628	From the real-time qRT-PCR analysis data, we found the marker genes of Prox-1 and Hif-1a were enriched and decreased in an isolated PVs compared to LVs, respectively.
33966247	2	36	theme	expressed	517:525	arg1	DEGs					534:537	DEGs	534:537	DEGs	534:537	RNA-Seq on the passed 10 samples on RNA-QC for two experimental groups with PVs and PVs + LVs proceeded to the library construction stage automatically and analyzed differentially expressed genes (DEGs).
33966247	2	36	theme	expressed	517:525	arg1	genes					527:531	differentially expressed genes	502:531	differentially expressed genes (DEGs)	502:538	RNA-Seq on the passed 10 samples on RNA-QC for two experimental groups with PVs and PVs + LVs proceeded to the library construction stage automatically and analyzed differentially expressed genes (DEGs).
33966247	3	37	theme	marker	596:601	arg1	genes					603:607	the marker genes	592:607	the marker genes of Prox-1 and Hif-1a	592:628	From the real-time qRT-PCR analysis data, we found the marker genes of Prox-1 and Hif-1a were enriched and decreased in an isolated PVs compared to LVs, respectively.
33966247	1	38	theme	gene	94:97	arg1	expression					99:108	The gene expression	90:108	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs)	90:231	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	3	39	theme	real-time	550:558	arg1	data					577:580	the real-time qRT-PCR analysis data	546:580	the real-time qRT-PCR analysis data	546:580	From the real-time qRT-PCR analysis data, we found the marker genes of Prox-1 and Hif-1a were enriched and decreased in an isolated PVs compared to LVs, respectively.
33966247	1	40	theme	composite	172:180	arg1	vessels					192:198	composite lymphatic vessels	172:198	composite lymphatic vessels	172:198	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	5	41	theme	high	959:962	arg1	levels					972:977	high and low levels	959:977	high and low levels of Prox-1 and Hif-1a	959:998	This finding indicates that high and low levels of Prox-1 and Hif-1a may be involved in the function of PVs and that pathophysiological and physiological condition could progress into inflamed lymphatic endothelial cells expanding the PV within the LV.
33966247	1	42	contain	containing	206:215	arg2	PVs					217:219	PVs	217:219	PVs (LVs + PVs)	217:231	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	1	42	contain	containing	206:215	arg1	PVs					163:165	PVs	163:165	PVs	163:165	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	1	42	contain	containing	206:215	arg1	vessels					154:160	the isolated primo vessels	135:160	the isolated primo vessels (PVs)	135:166	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	1	42	contain	containing	206:215	arg1	LVs					201:203	LVs	201:203	LVs	201:203	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	1	42	contain	containing	206:215	arg2	LVs + PVs					222:230	LVs + PVs	222:230	LVs + PVs	222:230	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	1	43	theme	lymphatic	182:190	arg1	vessels					192:198	composite lymphatic vessels	172:198	composite lymphatic vessels	172:198	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	4	44	theme	acupuncture	877:887	arg1	AES					911:913	AES	911:913	AES	911:913	Based on mRNA transcriptional data, Prox-1 and Hif-1a were increased and decreased in PVs compared to LVs + PVs under lipopolysaccharide (LPS) treatment and relieved by acupuncture electric stimulation (AES), respectively.
33966247	4	44	theme	acupuncture	877:887	arg1	stimulation					898:908	acupuncture electric stimulation	877:908	acupuncture electric stimulation (AES)	877:914	Based on mRNA transcriptional data, Prox-1 and Hif-1a were increased and decreased in PVs compared to LVs + PVs under lipopolysaccharide (LPS) treatment and relieved by acupuncture electric stimulation (AES), respectively.
33966247	2	45	from	RNA-Seq	337:343	arg1	RNA-QC					373:378	RNA-QC	373:378	RNA-QC	373:378	RNA-Seq on the passed 10 samples on RNA-QC for two experimental groups with PVs and PVs + LVs proceeded to the library construction stage automatically and analyzed differentially expressed genes (DEGs).
33966247	2	45	from	RNA-Seq	337:343	arg1	samples					362:368	the passed 10 samples	348:368	the passed 10 samples	348:368	RNA-Seq on the passed 10 samples on RNA-QC for two experimental groups with PVs and PVs + LVs proceeded to the library construction stage automatically and analyzed differentially expressed genes (DEGs).
33966247	1	46	theme	Prox-1	113:118	arg1	expression					99:108	The gene expression	90:108	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs)	90:231	The gene expression of Prox-1 and Hif-1a for the isolated primo vessels (PVs) and composite lymphatic vessels (LVs) containing PVs (LVs + PVs) was investigated by RNA-sequencing (Seq) and quantitative polymerase chain reaction (qRT-PCR) analysis.
33966247	2	47	with	groups	401:406	arg1	PVs + LVs					421:429	PVs + LVs	421:429	PVs + LVs	421:429	RNA-Seq on the passed 10 samples on RNA-QC for two experimental groups with PVs and PVs + LVs proceeded to the library construction stage automatically and analyzed differentially expressed genes (DEGs).
33966247	2	47	with	groups	401:406	arg1	PVs					413:415	PVs	413:415	PVs	413:415	RNA-Seq on the passed 10 samples on RNA-QC for two experimental groups with PVs and PVs + LVs proceeded to the library construction stage automatically and analyzed differentially expressed genes (DEGs).
33966247	5	48	theme	lymphatic	1124:1132	arg1	cells					1146:1150	inflamed lymphatic endothelial cells	1115:1150	inflamed lymphatic endothelial cells expanding the PV within the LV	1115:1181	This finding indicates that high and low levels of Prox-1 and Hif-1a may be involved in the function of PVs and that pathophysiological and physiological condition could progress into inflamed lymphatic endothelial cells expanding the PV within the LV.
32456440	11	0	contain	have	2028:2031	arg1	addition					2015:2022	the LTA addition	2007:2022	the LTA addition	2007:2022	The authors' results showed that the MOA for the Gram-positive SLBs was not sensitive to temperature, but the LTA addition did have an effect.
32456440	11	0	contain	have	2028:2031	arg2	effect					2036:2041	an effect	2033:2041	an effect	2033:2041	The authors' results showed that the MOA for the Gram-positive SLBs was not sensitive to temperature, but the LTA addition did have an effect.
32456440	2	1	with	mechanism	411:419	arg1	MOAs					460:463	specific MOAs	451:463	specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature	451:572	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	8	2	link	aureus-derived	1549:1562	arg1	LTA					1583:1585	LTA	1583:1585	LTA	1583:1585	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	8	2	link	aureus-derived	1549:1562	arg1	acid					1577:1580	S. aureus-derived lipoteichoic acid	1546:1580	S. aureus-derived lipoteichoic acid (LTA)	1546:1586	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	15	3	theme	transition	2710:2719	arg1	temperature					2721:2731	the gel-liquid crystal transition temperature	2687:2731	the gel-liquid crystal transition temperature of PE	2687:2737	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	15	3	theme	transition	2710:2719	arg1	25 °C					2742:2746	25 °C	2742:2746	25 °C	2742:2746	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	12	4	located	observed	2183:2190	arg1	37 °C.					2221:2226	37 °C.	2221:2226	37 °C.	2221:2226	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	12	4	located	observed	2183:2190	arg2	trends					2171:2176	the same mechanistic trends	2150:2176	the same mechanistic trends	2150:2176	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	12	4	located	observed	2183:2190	arg1	23					2214:2215	23	2214:2215	23	2214:2215	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	12	4	located	observed	2183:2190	arg1	plots					2205:2209	the polar plots	2195:2209	the polar plots	2195:2209	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	15	5	theme	gel-liquid	2691:2700	arg1	temperature					2721:2731	the gel-liquid crystal transition temperature	2687:2731	the gel-liquid crystal transition temperature of PE	2687:2737	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	15	5	theme	gel-liquid	2691:2700	arg1	25 °C					2742:2746	25 °C	2742:2746	25 °C	2742:2746	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	9	6	link	coli-derived	1713:1724	arg1	LPS					1747:1749	LPS	1747:1749	LPS	1747:1749	SLB models of Gram-negative bacterial membranes were formed using combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS).
32456440	9	6	link	coli-derived	1713:1724	arg1	lipopolysaccharides					1726:1744	E. coli-derived lipopolysaccharides	1710:1744	E. coli-derived lipopolysaccharides (LPS)	1710:1750	SLB models of Gram-negative bacterial membranes were formed using combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS).
32456440	1	7	theme	low	293:295	arg1	likelihood					297:306	a low likelihood	291:306	a low likelihood of incurring antimicrobial resistance	291:344	Antimicrobial peptides (AMPs) are attractive as biomaterial coatings because they have broad spectrum activity against different microbes, with a low likelihood of incurring antimicrobial resistance.
32456440	12	8	theme	similar	2058:2064	arg1	trends					2066:2071	similar trends	2058:2071	similar trends in frequency and dissipation changes across all overtones	2058:2129	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	9	9	theme	PG	1702:1703	arg1	combinations					1655:1666	combinations	1655:1666	combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS)	1655:1750	SLB models of Gram-negative bacterial membranes were formed using combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS).
32456440	6	10	theme	typical	1157:1163	arg1	temperatures					1169:1180	typical lab temperatures	1157:1180	typical lab temperatures	1157:1180	These two temperatures were used so that the authors could better understand the differences in behavior between typical lab temperatures and physiologic conditions.
32456440	1	11	theme	biomaterial	195:205	arg1	coatings					207:214	biomaterial coatings	195:214	biomaterial coatings	195:214	Antimicrobial peptides (AMPs) are attractive as biomaterial coatings because they have broad spectrum activity against different microbes, with a low likelihood of incurring antimicrobial resistance.
32456440	13	12	theme	saturation	2459:2468	arg1	point					2470:2474	the saturation point	2455:2474	the saturation point	2455:2474	This was demonstrated by significant changes in dissipation, while the frequency (mass) was not increasing after the saturation point.
32456440	2	13	theme	Direct	347:352	arg1	mechanism					411:419	the most common mechanism	395:419	the most common mechanism of action (MOA) of AMPs	395:443	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	2	13	theme	Direct	347:352	arg1	action					354:359	Direct action	347:359	Direct action against the bacterial membrane	347:390	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	3	14	dep	salt-tolerant	616:628	arg1	AMP					630:632	AMP	630:632	AMP	630:632	Chrysophsin-1 (CHY1) is a broad spectrum salt-tolerant AMP that is derived from a marine fish.
32456440	9	15	theme	coli-derived	1713:1724	arg1	LPS					1747:1749	LPS	1747:1749	LPS	1747:1749	SLB models of Gram-negative bacterial membranes were formed using combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS).
32456440	9	15	theme	coli-derived	1713:1724	arg1	lipopolysaccharides					1726:1744	E. coli-derived lipopolysaccharides	1710:1744	E. coli-derived lipopolysaccharides (LPS)	1710:1750	SLB models of Gram-negative bacterial membranes were formed using combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS).
32456440	5	16	with	MOA	935:937	arg1	membranes					988:996	model membranes	982:996	model membranes comprised of supported lipid bilayers (SLBs)	982:1041	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	10	17	theme	Gram-negative	1802:1814	arg1	membranes					1816:1824	Gram-positive and Gram-negative membranes	1784:1824	Gram-positive and Gram-negative membranes (LTA and LPS)	1784:1838	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS) have the potential to alter the MOA of C-CHY1 with the SLBs.
32456440	10	17	theme	Gram-negative	1802:1814	arg1	LPS					1835:1837	LPS	1835:1837	LPS	1835:1837	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS) have the potential to alter the MOA of C-CHY1 with the SLBs.
32456440	10	17	theme	Gram-negative	1802:1814	arg1	LTA					1827:1829	LTA	1827:1829	LTA	1827:1829	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS) have the potential to alter the MOA of C-CHY1 with the SLBs.
32456440	5	18	theme	dissipation	836:846	arg1	monitoring					848:857	dissipation monitoring	836:857	dissipation monitoring	836:857	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	20	19	theme	rational	3336:3343	arg1	design					3345:3350	the more rational design	3327:3350	the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings	3327:3470	A better understanding of C-CHY1 MOA using different SLB models will allow for the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings.
32456440	5	20	theme	lipid	903:907	arg1	composition					909:919	lipid composition	903:919	lipid composition	903:919	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	7	21	theme	bacterial	1393:1401	arg1	systems					1403:1409	bacterial systems	1393:1409	bacterial systems	1393:1409	The authors created model membranes that mimicked properties of Gram-negative and Gram-positive bacteria in order to understand how the mechanisms might differ for different types of bacterial systems.
32456440	3	22	theme	salt-tolerant	616:628	arg1	spectrum					607:614	a broad spectrum	599:614	a broad spectrum salt-tolerant AMP that is derived from a marine fish	599:667	Chrysophsin-1 (CHY1) is a broad spectrum salt-tolerant AMP that is derived from a marine fish.
32456440	3	22	theme	salt-tolerant	616:628	arg1	Chrysophsin-1					575:587	Chrysophsin-1	575:587	Chrysophsin-1 (CHY1)	575:594	Chrysophsin-1 (CHY1) is a broad spectrum salt-tolerant AMP that is derived from a marine fish.
32456440	6	23	used	used	1072:1075	arg2	temperatures					1054:1065	These two temperatures	1044:1065	These two temperatures	1044:1065	These two temperatures were used so that the authors could better understand the differences in behavior between typical lab temperatures and physiologic conditions.
32456440	1	24	theme	spectrum	240:247	arg1	activity					249:256	broad spectrum activity	234:256	broad spectrum activity against different microbes	234:283	Antimicrobial peptides (AMPs) are attractive as biomaterial coatings because they have broad spectrum activity against different microbes, with a low likelihood of incurring antimicrobial resistance.
32456440	20	25	theme	different	3291:3299	arg1	models					3305:3310	different SLB models	3291:3310	different SLB models	3291:3310	A better understanding of C-CHY1 MOA using different SLB models will allow for the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings.
32456440	18	26	theme	energetic	3123:3131	arg1	requirement					3133:3143	an energetic requirement	3120:3143	an energetic requirement for insertion	3120:3157	At 37 °C, the membrane is more fluid and there is less of an energetic requirement for insertion.
32456440	10	27	dep	membranes	1816:1824	arg1	membranes					1816:1824	Gram-positive and Gram-negative membranes	1784:1824	Gram-positive and Gram-negative membranes (LTA and LPS)	1784:1838	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS) have the potential to alter the MOA of C-CHY1 with the SLBs.
32456440	10	27	dep	membranes	1816:1824	arg1	LPS					1835:1837	LPS	1835:1837	LPS	1835:1837	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS) have the potential to alter the MOA of C-CHY1 with the SLBs.
32456440	10	27	dep	membranes	1816:1824	arg1	LTA					1827:1829	LTA	1827:1829	LTA	1827:1829	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS) have the potential to alter the MOA of C-CHY1 with the SLBs.
32456440	3	28	theme	broad	601:605	arg1	spectrum					607:614	a broad spectrum	599:614	a broad spectrum salt-tolerant AMP that is derived from a marine fish	599:667	Chrysophsin-1 (CHY1) is a broad spectrum salt-tolerant AMP that is derived from a marine fish.
32456440	3	28	theme	broad	601:605	arg1	Chrysophsin-1					575:587	Chrysophsin-1	575:587	Chrysophsin-1 (CHY1)	575:594	Chrysophsin-1 (CHY1) is a broad spectrum salt-tolerant AMP that is derived from a marine fish.
32456440	1	29	theme	Antimicrobial	147:159	arg1	peptides					161:168	Antimicrobial peptides	147:168	Antimicrobial peptides (AMPs)	147:175	Antimicrobial peptides (AMPs) are attractive as biomaterial coatings because they have broad spectrum activity against different microbes, with a low likelihood of incurring antimicrobial resistance.
32456440	1	29	theme	Antimicrobial	147:159	arg1	AMPs					171:174	AMPs	171:174	AMPs	171:174	Antimicrobial peptides (AMPs) are attractive as biomaterial coatings because they have broad spectrum activity against different microbes, with a low likelihood of incurring antimicrobial resistance.
32456440	3	30	attach	derived	642:648	arg1	fish					664:667	a marine fish	655:667	a marine fish	655:667	Chrysophsin-1 (CHY1) is a broad spectrum salt-tolerant AMP that is derived from a marine fish.
32456440	3	30	attach	derived	642:648	arg2	Chrysophsin-1					575:587	Chrysophsin-1	575:587	Chrysophsin-1 (CHY1)	575:594	Chrysophsin-1 (CHY1) is a broad spectrum salt-tolerant AMP that is derived from a marine fish.
32456440	3	30	attach	derived	642:648	arg2	spectrum					607:614	a broad spectrum	599:614	a broad spectrum salt-tolerant AMP that is derived from a marine fish	599:667	Chrysophsin-1 (CHY1) is a broad spectrum salt-tolerant AMP that is derived from a marine fish.
32456440	8	31	theme	phosphatidylcholine	1494:1512	arg1	combinations					1478:1489	combinations	1478:1489	combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA)	1478:1586	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	12	32	theme	mechanistic	2159:2169	arg1	trends					2171:2176	the same mechanistic trends	2150:2176	the same mechanistic trends	2150:2176	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	8	33	theme	phosphatidylglycerol	1515:1534	arg1	combinations					1478:1489	combinations	1478:1489	combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA)	1478:1586	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	6	34	theme	physiologic	1186:1196	arg1	conditions					1198:1207	physiologic conditions	1186:1207	physiologic conditions	1186:1207	These two temperatures were used so that the authors could better understand the differences in behavior between typical lab temperatures and physiologic conditions.
32456440	18	35	from	37 °C	3065:3069	arg1	membrane					3076:3083	the membrane	3072:3083	the membrane	3072:3083	At 37 °C, the membrane is more fluid and there is less of an energetic requirement for insertion.
32456440	18	35	from	37 °C	3065:3069	arg1	fluid					3093:3097	fluid	3093:3097	fluid	3093:3097	At 37 °C, the membrane is more fluid and there is less of an energetic requirement for insertion.
32456440	7	36	theme	model	1230:1234	arg1	membranes					1236:1244	model membranes	1230:1244	model membranes that mimicked properties of Gram-negative and Gram-positive bacteria in order to understand how the mechanisms might differ for different types of bacterial systems	1230:1409	The authors created model membranes that mimicked properties of Gram-negative and Gram-positive bacteria in order to understand how the mechanisms might differ for different types of bacterial systems.
32456440	2	37	theme	peptide	500:506	arg1	concentration					508:520	peptide concentration	500:520	peptide concentration	500:520	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	0	38	theme	model	88:92	arg1	membranes					136:144	model Gram-positive and Gram-negative bacterial membranes	88:144	model Gram-positive and Gram-negative bacterial membranes	88:144	Role of lipopolysaccharides and lipoteichoic acids on C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes.
32456440	20	39	theme	peptides	3415:3422	arg1	use					3394:3396	use	3394:3396	use of antimicrobial peptides	3394:3422	A better understanding of C-CHY1 MOA using different SLB models will allow for the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings.
32456440	3	40	theme	marine	657:662	arg1	fish					664:667	a marine fish	655:667	a marine fish	655:667	Chrysophsin-1 (CHY1) is a broad spectrum salt-tolerant AMP that is derived from a marine fish.
32456440	0	41	from	Role	0:3	arg1	interactions					70:81	C-Chrysophsin-1 interactions	54:81	C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes	54:144	Role of lipopolysaccharides and lipoteichoic acids on C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes.
32456440	5	42	theme	cysteine-modified	942:958	arg1	C-CHY1					969:974	C-CHY1	969:974	C-CHY1	969:974	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	5	42	theme	cysteine-modified	942:958	arg1	peptide					960:966	cysteine-modified peptide	942:966	cysteine-modified peptide (C-CHY1)	942:975	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	17	43	theme	mass	3047:3050	arg1	addition					3052:3059	very little mass addition	3035:3059	very little mass addition	3035:3059	This could be seen in the polar plots, where there was a steep slope but there was very little mass addition.
32456440	10	44	theme	Gram-positive	1784:1796	arg1	membranes					1816:1824	Gram-positive and Gram-negative membranes	1784:1824	Gram-positive and Gram-negative membranes (LTA and LPS)	1784:1838	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS) have the potential to alter the MOA of C-CHY1 with the SLBs.
32456440	10	44	theme	Gram-positive	1784:1796	arg1	LPS					1835:1837	LPS	1835:1837	LPS	1835:1837	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS) have the potential to alter the MOA of C-CHY1 with the SLBs.
32456440	10	44	theme	Gram-positive	1784:1796	arg1	LTA					1827:1829	LTA	1827:1829	LTA	1827:1829	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS) have the potential to alter the MOA of C-CHY1 with the SLBs.
32456440	14	45	theme	Gram-negative	2485:2497	arg1	SLBs					2499:2502	the Gram-negative SLBs	2481:2502	the Gram-negative SLBs	2481:2502	For the Gram-negative SLBs, the composition did not have a significant effect on MOA, but the authors saw more differences between the two temperatures studied.
32456440	2	46	theme	environmental	527:539	arg1	factors					541:547	environmental factors	527:547	environmental factors that include temperature	527:572	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	8	47	theme	S.	1546:1547	arg1	LTA					1583:1585	LTA	1583:1585	LTA	1583:1585	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	8	47	theme	S.	1546:1547	arg1	acid					1577:1580	S. aureus-derived lipoteichoic acid	1546:1580	S. aureus-derived lipoteichoic acid (LTA)	1546:1586	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	4	48	theme	biomedical	767:776	arg1	device					778:783	a biomedical device	765:783	a biomedical device	765:783	A cysteine modification was made to the peptide to facilitate attachment to a surface, such as a biomedical device.
32456440	0	49	theme	bacterial	126:134	arg1	membranes					136:144	model Gram-positive and Gram-negative bacterial membranes	88:144	model Gram-positive and Gram-negative bacterial membranes	88:144	Role of lipopolysaccharides and lipoteichoic acids on C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes.
32456440	16	50	theme	significant	2867:2877	arg1	shift					2889:2893	a significant energetic shift	2865:2893	a significant energetic shift	2865:2893	At 23 °C, a significant energetic shift would be required to allow for additional AMP insertion.
32456440	20	51	theme	MOA	3281:3283	arg1	understanding					3257:3269	A better understanding	3248:3269	A better understanding of C-CHY1 MOA using different SLB models	3248:3310	A better understanding of C-CHY1 MOA using different SLB models will allow for the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings.
32456440	8	52	theme	lipoteichoic	1564:1575	arg1	LTA					1583:1585	LTA	1583:1585	LTA	1583:1585	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	8	52	theme	lipoteichoic	1564:1575	arg1	acid					1577:1580	S. aureus-derived lipoteichoic acid	1546:1580	S. aureus-derived lipoteichoic acid (LTA)	1546:1586	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	13	53	theme	significant	2367:2377	arg1	changes					2379:2385	significant changes	2367:2385	significant changes in dissipation	2367:2400	This was demonstrated by significant changes in dissipation, while the frequency (mass) was not increasing after the saturation point.
32456440	5	54	theme	quartz	803:808	arg1	microbalance					818:829	quartz crystal microbalance	803:829	quartz crystal microbalance with dissipation monitoring	803:857	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	15	55	dep	rigid	2786:2790	arg1	bilayer					2770:2776	the bilayer	2766:2776	the bilayer	2766:2776	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	15	55	dep	rigid	2786:2790	arg1	rigid					2786:2790	rigid	2786:2790	rigid	2786:2790	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	15	55	dep	rigid	2786:2790	arg1	compared					2802:2809	compared	2802:2809	compared to temperatures above the transition point	2802:2852	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	12	56	theme	polar	2199:2203	arg1	plots					2205:2209	the polar plots	2195:2209	the polar plots	2195:2209	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	5	57	dep	temperature	872:882	arg1	37 °C					892:896	37 °C	892:896	37 °C	892:896	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	5	57	dep	temperature	872:882	arg1	23					885:886	23	885:886	23	885:886	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	2	58	theme	AMPs	440:443	arg1	action					424:429	action	424:429	action (MOA) of AMPs	424:443	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	2	58	theme	AMPs	440:443	arg1	MOA					432:434	MOA	432:434	MOA	432:434	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	0	59	theme	lipopolysaccharides	8:26	arg1	Role					0:3	Role	0:3	Role of lipopolysaccharides and lipoteichoic acids on C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes.	0:145	Role of lipopolysaccharides and lipoteichoic acids on C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes.
32456440	17	60	theme	polar	2978:2982	arg1	plots					2984:2988	the polar plots	2974:2988	the polar plots	2974:2988	This could be seen in the polar plots, where there was a steep slope but there was very little mass addition.
32456440	9	61	theme	Gram-negative	1603:1615	arg1	membranes					1627:1635	Gram-negative bacterial membranes	1603:1635	Gram-negative bacterial membranes	1603:1635	SLB models of Gram-negative bacterial membranes were formed using combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS).
32456440	20	62	theme	better	3250:3255	arg1	understanding					3257:3269	A better understanding	3248:3269	A better understanding of C-CHY1 MOA using different SLB models	3248:3310	A better understanding of C-CHY1 MOA using different SLB models will allow for the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings.
32456440	8	63	theme	SLB	1412:1414	arg1	models					1416:1421	SLB models	1412:1421	SLB models of Gram-positive bacterial membranes	1412:1458	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	0	64	theme	lipoteichoic	32:43	arg1	acids					45:49	lipoteichoic acids	32:49	lipoteichoic acids	32:49	Role of lipopolysaccharides and lipoteichoic acids on C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes.
32456440	9	65	theme	membranes	1627:1635	arg1	models					1593:1598	SLB models	1589:1598	SLB models of Gram-negative bacterial membranes	1589:1635	SLB models of Gram-negative bacterial membranes were formed using combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS).
32456440	19	66	theme	greater	3192:3198	arg1	addition					3205:3212	greater mass addition	3192:3212	greater mass addition	3192:3212	Therefore, the authors observed greater mass addition and fewer changes in dissipation.
32456440	16	67	theme	energetic	2879:2887	arg1	shift					2889:2893	a significant energetic shift	2865:2893	a significant energetic shift	2865:2893	At 23 °C, a significant energetic shift would be required to allow for additional AMP insertion.
32456440	7	68	theme	Gram-positive	1292:1304	arg1	bacteria					1306:1313	Gram-negative and Gram-positive bacteria	1274:1313	Gram-negative and Gram-positive bacteria in order to understand how the mechanisms might differ for different types of bacterial systems	1274:1409	The authors created model membranes that mimicked properties of Gram-negative and Gram-positive bacteria in order to understand how the mechanisms might differ for different types of bacterial systems.
32456440	20	69	theme	C-CHY1	3274:3279	arg1	MOA					3281:3283	C-CHY1 MOA	3274:3283	C-CHY1 MOA using different SLB models	3274:3310	A better understanding of C-CHY1 MOA using different SLB models will allow for the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings.
32456440	8	70	theme	bacterial	1440:1448	arg1	membranes					1450:1458	Gram-positive bacterial membranes	1426:1458	Gram-positive bacterial membranes	1426:1458	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	5	71	theme	supported	1011:1019	arg1	SLBs					1037:1040	SLBs	1037:1040	SLBs	1037:1040	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	5	71	theme	supported	1011:1019	arg1	bilayers					1027:1034	supported lipid bilayers	1011:1034	supported lipid bilayers (SLBs)	1011:1041	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	5	72	used	used	798:801	arg2	authors					790:796	The authors	786:796	The authors	786:796	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	5	73	theme	model	982:986	arg1	membranes					988:996	model membranes	982:996	model membranes comprised of supported lipid bilayers (SLBs)	982:1041	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	7	74	theme	Gram-negative	1274:1286	arg1	bacteria					1306:1313	Gram-negative and Gram-positive bacteria	1274:1313	Gram-negative and Gram-positive bacteria in order to understand how the mechanisms might differ for different types of bacterial systems	1274:1409	The authors created model membranes that mimicked properties of Gram-negative and Gram-positive bacteria in order to understand how the mechanisms might differ for different types of bacterial systems.
32456440	12	75	theme	SLB	2326:2328	arg1	saturation					2330:2339	SLB saturation	2326:2339	SLB saturation	2326:2339	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	17	76	theme	steep	3009:3013	arg1	slope					3015:3019	a steep slope	3007:3019	a steep slope	3007:3019	This could be seen in the polar plots, where there was a steep slope but there was very little mass addition.
32456440	2	77	theme	common	404:409	arg1	mechanism					411:419	the most common mechanism	395:419	the most common mechanism of action (MOA) of AMPs	395:443	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	2	77	theme	common	404:409	arg1	action					354:359	Direct action	347:359	Direct action against the bacterial membrane	347:390	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	1	78	theme	different	266:274	arg1	microbes					276:283	different microbes	266:283	different microbes	266:283	Antimicrobial peptides (AMPs) are attractive as biomaterial coatings because they have broad spectrum activity against different microbes, with a low likelihood of incurring antimicrobial resistance.
32456440	9	79	theme	phosphatidylethanolamine	1671:1694	arg1	combinations					1655:1666	combinations	1655:1666	combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS)	1655:1750	SLB models of Gram-negative bacterial membranes were formed using combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS).
32456440	14	80	theme	more	2583:2586	arg1	differences					2588:2598	more differences	2583:2598	more differences between the two temperatures studied	2583:2635	For the Gram-negative SLBs, the composition did not have a significant effect on MOA, but the authors saw more differences between the two temperatures studied.
32456440	9	81	dep	coli-derived	1713:1724	arg1	E.					1710:1711	E.	1710:1711	E.	1710:1711	SLB models of Gram-negative bacterial membranes were formed using combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS).
32456440	15	82	theme	crystal	2702:2708	arg1	temperature					2721:2731	the gel-liquid crystal transition temperature	2687:2731	the gel-liquid crystal transition temperature of PE	2687:2737	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	15	82	theme	crystal	2702:2708	arg1	25 °C					2742:2746	25 °C	2742:2746	25 °C	2742:2746	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	12	83	dep	37 °C.	2221:2226	arg1	showed					2269:2274	showed	2269:2274	showed	2269:2274	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	6	84	theme	lab	1165:1167	arg1	temperatures					1169:1180	typical lab temperatures	1157:1180	typical lab temperatures	1157:1180	These two temperatures were used so that the authors could better understand the differences in behavior between typical lab temperatures and physiologic conditions.
32456440	0	85	with	interactions	70:81	arg1	membranes					136:144	model Gram-positive and Gram-negative bacterial membranes	88:144	model Gram-positive and Gram-negative bacterial membranes	88:144	Role of lipopolysaccharides and lipoteichoic acids on C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes.
32456440	20	86	theme	SLB	3301:3303	arg1	models					3305:3310	different SLB models	3291:3310	different SLB models	3291:3310	A better understanding of C-CHY1 MOA using different SLB models will allow for the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings.
32456440	20	87	theme	future	3355:3360	arg1	solutions					3374:3382	future therapeutic solutions	3355:3382	future therapeutic solutions	3355:3382	A better understanding of C-CHY1 MOA using different SLB models will allow for the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings.
32456440	20	87	theme	future	3355:3360	arg1	those					3435:3439	those	3435:3439	those	3435:3439	A better understanding of C-CHY1 MOA using different SLB models will allow for the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings.
32456440	5	88	with	microbalance	818:829	arg1	monitoring					848:857	dissipation monitoring	836:857	dissipation monitoring	836:857	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	4	89	theme	cysteine	672:679	arg1	modification					681:692	A cysteine modification	670:692	A cysteine modification	670:692	A cysteine modification was made to the peptide to facilitate attachment to a surface, such as a biomedical device.
32456440	11	90	theme	LTA	2011:2013	arg1	addition					2015:2022	the LTA addition	2007:2022	the LTA addition	2007:2022	The authors' results showed that the MOA for the Gram-positive SLBs was not sensitive to temperature, but the LTA addition did have an effect.
32456440	20	91	theme	solutions	3374:3382	arg1	design					3345:3350	the more rational design	3327:3350	the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings	3327:3470	A better understanding of C-CHY1 MOA using different SLB models will allow for the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings.
32456440	9	92	theme	lipopolysaccharides	1726:1744	arg1	combinations					1655:1666	combinations	1655:1666	combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS)	1655:1750	SLB models of Gram-negative bacterial membranes were formed using combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS).
32456440	12	93	theme	frequency	2076:2084	arg1	changes					2102:2108	frequency and dissipation changes	2076:2108	frequency and dissipation changes across all overtones	2076:2129	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	11	94	theme	Gram-positive	1950:1962	arg1	SLBs					1964:1967	the Gram-positive SLBs	1946:1967	the Gram-positive SLBs	1946:1967	The authors' results showed that the MOA for the Gram-positive SLBs was not sensitive to temperature, but the LTA addition did have an effect.
32456440	14	95	contain	have	2529:2532	arg1	composition					2509:2519	the composition	2505:2519	the composition	2505:2519	For the Gram-negative SLBs, the composition did not have a significant effect on MOA, but the authors saw more differences between the two temperatures studied.
32456440	14	95	contain	have	2529:2532	arg2	effect					2548:2553	a significant effect	2534:2553	a significant effect	2534:2553	For the Gram-negative SLBs, the composition did not have a significant effect on MOA, but the authors saw more differences between the two temperatures studied.
32456440	1	96	theme	broad	234:238	arg1	spectrum					240:247	broad spectrum	234:247	broad spectrum activity against different microbes	234:283	Antimicrobial peptides (AMPs) are attractive as biomaterial coatings because they have broad spectrum activity against different microbes, with a low likelihood of incurring antimicrobial resistance.
32456440	7	97	theme	systems	1403:1409	arg1	types					1384:1388	different types	1374:1388	different types of bacterial systems	1374:1409	The authors created model membranes that mimicked properties of Gram-negative and Gram-positive bacteria in order to understand how the mechanisms might differ for different types of bacterial systems.
32456440	12	98	theme	dissipation	2090:2100	arg1	changes					2102:2108	frequency and dissipation changes	2076:2108	frequency and dissipation changes across all overtones	2076:2129	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	15	99	theme	PE	2736:2737	arg1	temperature					2721:2731	the gel-liquid crystal transition temperature	2687:2731	the gel-liquid crystal transition temperature of PE	2687:2737	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	15	99	theme	PE	2736:2737	arg1	25 °C					2742:2746	25 °C	2742:2746	25 °C	2742:2746	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	12	100	from	trends	2066:2071	arg1	changes					2102:2108	frequency and dissipation changes	2076:2108	frequency and dissipation changes across all overtones	2076:2129	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	14	101	theme	significant	2536:2546	arg1	effect					2548:2553	a significant effect	2534:2553	a significant effect	2534:2553	For the Gram-negative SLBs, the composition did not have a significant effect on MOA, but the authors saw more differences between the two temperatures studied.
32456440	7	102	theme	different	1374:1382	arg1	types					1384:1388	different types	1374:1388	different types of bacterial systems	1374:1409	The authors created model membranes that mimicked properties of Gram-negative and Gram-positive bacteria in order to understand how the mechanisms might differ for different types of bacterial systems.
32456440	20	103	dep	future	3355:3360	arg1	therapeutic					3362:3372	therapeutic	3362:3372	therapeutic	3362:3372	A better understanding of C-CHY1 MOA using different SLB models will allow for the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings.
32456440	0	104	theme	Gram-positive	94:106	arg1	membranes					136:144	model Gram-positive and Gram-negative bacterial membranes	88:144	model Gram-positive and Gram-negative bacterial membranes	88:144	Role of lipopolysaccharides and lipoteichoic acids on C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes.
32456440	13	105	from	changes	2379:2385	arg1	dissipation					2390:2400	dissipation	2390:2400	dissipation	2390:2400	This was demonstrated by significant changes in dissipation, while the frequency (mass) was not increasing after the saturation point.
32456440	17	106	theme	little	3040:3045	arg1	addition					3052:3059	very little mass addition	3035:3059	very little mass addition	3035:3059	This could be seen in the polar plots, where there was a steep slope but there was very little mass addition.
32456440	0	107	theme	Gram-negative	112:124	arg1	membranes					136:144	model Gram-positive and Gram-negative bacterial membranes	88:144	model Gram-positive and Gram-negative bacterial membranes	88:144	Role of lipopolysaccharides and lipoteichoic acids on C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes.
32456440	5	108	theme	peptide	960:966	arg1	MOA					935:937	the MOA	931:937	the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs)	931:1041	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	15	109	from	23 °C	2795:2799	arg1	bilayer					2770:2776	the bilayer	2766:2776	the bilayer	2766:2776	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	15	109	from	23 °C	2795:2799	arg1	rigid					2786:2790	rigid	2786:2790	rigid	2786:2790	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	15	109	from	23 °C	2795:2799	arg1	compared					2802:2809	compared	2802:2809	compared to temperatures above the transition point	2802:2852	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	8	110	theme	aureus-derived	1549:1562	arg1	LTA					1583:1585	LTA	1583:1585	LTA	1583:1585	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	8	110	theme	aureus-derived	1549:1562	arg1	acid					1577:1580	S. aureus-derived lipoteichoic acid	1546:1580	S. aureus-derived lipoteichoic acid (LTA)	1546:1586	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	16	111	theme	AMP	2937:2939	arg1	insertion					2941:2949	additional AMP insertion	2926:2949	additional AMP insertion	2926:2949	At 23 °C, a significant energetic shift would be required to allow for additional AMP insertion.
32456440	19	112	from	addition	3205:3212	arg1	dissipation					3235:3245	dissipation	3235:3245	dissipation	3235:3245	Therefore, the authors observed greater mass addition and fewer changes in dissipation.
32456440	8	113	theme	acid	1577:1580	arg1	combinations					1478:1489	combinations	1478:1489	combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA)	1478:1586	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	2	114	theme	action	424:429	arg1	mechanism					411:419	the most common mechanism	395:419	the most common mechanism of action (MOA) of AMPs	395:443	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	2	114	theme	action	424:429	arg1	action					354:359	Direct action	347:359	Direct action against the bacterial membrane	347:390	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	20	115	theme	antimicrobial	3401:3413	arg1	peptides					3415:3422	antimicrobial peptides	3401:3422	antimicrobial peptides	3401:3422	A better understanding of C-CHY1 MOA using different SLB models will allow for the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings.
32456440	9	116	theme	SLB	1589:1591	arg1	models					1593:1598	SLB models	1589:1598	SLB models of Gram-negative bacterial membranes	1589:1635	SLB models of Gram-negative bacterial membranes were formed using combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS).
32456440	12	117	theme	polar	2257:2261	arg1	plots					2263:2267	polar plots	2257:2267	polar plots	2257:2267	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	2	118	theme	specific	451:458	arg1	MOAs					460:463	specific MOAs	451:463	specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature	451:572	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	19	119	theme	fewer	3218:3222	arg1	changes					3224:3230	fewer changes	3218:3230	fewer changes in dissipation	3218:3245	Therefore, the authors observed greater mass addition and fewer changes in dissipation.
32456440	6	120	from	differences	1125:1135	arg1	behavior					1140:1147	behavior	1140:1147	behavior	1140:1147	These two temperatures were used so that the authors could better understand the differences in behavior between typical lab temperatures and physiologic conditions.
32456440	5	121	theme	crystal	810:816	arg1	microbalance					818:829	quartz crystal microbalance	803:829	quartz crystal microbalance with dissipation monitoring	803:857	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	15	122	theme	transition	2837:2846	arg1	point					2848:2852	the transition point	2833:2852	the transition point	2833:2852	The authors believe this is due to the fact that the gel-liquid crystal transition temperature of PE is 25 °C, which means that the bilayer is more rigid at 23 °C, compared to temperatures above the transition point.
32456440	10	123	contain	have	1840:1843	arg2	potential					1849:1857	the potential to alter the MOA of C-CHY1 with the SLBs	1845:1898	the potential to alter the MOA of C-CHY1 with the SLBs	1845:1898	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS) have the potential to alter the MOA of C-CHY1 with the SLBs.
32456440	10	123	contain	have	1840:1843	arg1	molecules					1757:1765	The molecules	1753:1765	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS)	1753:1838	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS) have the potential to alter the MOA of C-CHY1 with the SLBs.
32456440	10	124	theme	C-CHY1	1879:1884	arg1	MOA					1872:1874	the MOA	1868:1874	the MOA of C-CHY1 with the SLBs	1868:1898	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS) have the potential to alter the MOA of C-CHY1 with the SLBs.
32456440	0	125	theme	acids	45:49	arg1	Role					0:3	Role	0:3	Role of lipopolysaccharides and lipoteichoic acids on C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes.	0:145	Role of lipopolysaccharides and lipoteichoic acids on C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes.
32456440	1	126	theme	antimicrobial	321:333	arg1	resistance					335:344	antimicrobial resistance	321:344	antimicrobial resistance	321:344	Antimicrobial peptides (AMPs) are attractive as biomaterial coatings because they have broad spectrum activity against different microbes, with a low likelihood of incurring antimicrobial resistance.
32456440	9	127	theme	bacterial	1617:1625	arg1	membranes					1627:1635	Gram-negative bacterial membranes	1603:1635	Gram-negative bacterial membranes	1603:1635	SLB models of Gram-negative bacterial membranes were formed using combinations of phosphatidylethanolamine (PE), PG, and E. coli-derived lipopolysaccharides (LPS).
32456440	7	128	theme	bacteria	1306:1313	arg1	properties					1260:1269	properties	1260:1269	properties of Gram-negative and Gram-positive bacteria in order to understand how the mechanisms might differ for different types of bacterial systems	1260:1409	The authors created model membranes that mimicked properties of Gram-negative and Gram-positive bacteria in order to understand how the mechanisms might differ for different types of bacterial systems.
32456440	2	129	theme	membrane	478:485	arg1	composition					487:497	membrane composition	478:497	membrane composition	478:497	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	19	130	theme	mass	3200:3203	arg1	addition					3205:3212	greater mass addition	3192:3212	greater mass addition	3192:3212	Therefore, the authors observed greater mass addition and fewer changes in dissipation.
32456440	12	131	theme	same	2154:2157	arg1	trends					2171:2176	the same mechanistic trends	2150:2176	the same mechanistic trends	2150:2176	Specifically, similar trends in frequency and dissipation changes across all overtones were observed, and the same mechanistic trends were observed in the polar plots at 23 and 37 °C. However, when LTA was added, polar plots showed an association between C-CHY1 and LTA, leading to SLB saturation.
32456440	16	132	theme	additional	2926:2935	arg1	insertion					2941:2949	additional AMP insertion	2926:2949	additional AMP insertion	2926:2949	At 23 °C, a significant energetic shift would be required to allow for additional AMP insertion.
32456440	0	133	theme	C-Chrysophsin-1	54:68	arg1	interactions					70:81	C-Chrysophsin-1 interactions	54:81	C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes	54:144	Role of lipopolysaccharides and lipoteichoic acids on C-Chrysophsin-1 interactions with model Gram-positive and Gram-negative bacterial membranes.
32456440	20	134	theme	biomaterial	3451:3461	arg1	coatings					3463:3470	biomaterial coatings	3451:3470	biomaterial coatings	3451:3470	A better understanding of C-CHY1 MOA using different SLB models will allow for the more rational design of future therapeutic solutions that make use of antimicrobial peptides, including those involving biomaterial coatings.
32456440	5	135	theme	lipid	1021:1025	arg1	SLBs					1037:1040	SLBs	1037:1040	SLBs	1037:1040	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	5	135	theme	lipid	1021:1025	arg1	bilayers					1027:1034	supported lipid bilayers	1011:1034	supported lipid bilayers (SLBs)	1011:1041	The authors used quartz crystal microbalance with dissipation monitoring to study how temperature (23 and 37 °C) and lipid composition influence the MOA of cysteine-modified peptide (C-CHY1) with model membranes comprised of supported lipid bilayers (SLBs).
32456440	10	136	with	MOA	1872:1874	arg1	SLBs					1895:1898	the SLBs	1891:1898	the SLBs	1891:1898	The molecules that distinguish Gram-positive and Gram-negative membranes (LTA and LPS) have the potential to alter the MOA of C-CHY1 with the SLBs.
32456440	2	137	theme	dependent	465:473	arg1	MOAs					460:463	specific MOAs	451:463	specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature	451:572	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	19	138	from	changes	3224:3230	arg1	dissipation					3235:3245	dissipation	3235:3245	dissipation	3235:3245	Therefore, the authors observed greater mass addition and fewer changes in dissipation.
32456440	2	139	theme	bacterial	373:381	arg1	membrane					383:390	the bacterial membrane	369:390	the bacterial membrane	369:390	Direct action against the bacterial membrane is the most common mechanism of action (MOA) of AMPs, with specific MOAs dependent on membrane composition, peptide concentration, and environmental factors that include temperature.
32456440	1	140	contain	have	229:232	arg2	activity					249:256	broad spectrum activity	234:256	broad spectrum activity against different microbes	234:283	Antimicrobial peptides (AMPs) are attractive as biomaterial coatings because they have broad spectrum activity against different microbes, with a low likelihood of incurring antimicrobial resistance.
32456440	1	140	contain	have	229:232	arg1	they					224:227	they	224:227	they	224:227	Antimicrobial peptides (AMPs) are attractive as biomaterial coatings because they have broad spectrum activity against different microbes, with a low likelihood of incurring antimicrobial resistance.
32456440	8	141	theme	Gram-positive	1426:1438	arg1	membranes					1450:1458	Gram-positive bacterial membranes	1426:1458	Gram-positive bacterial membranes	1426:1458	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
32456440	8	142	theme	membranes	1450:1458	arg1	models					1416:1421	SLB models	1412:1421	SLB models of Gram-positive bacterial membranes	1412:1458	SLB models of Gram-positive bacterial membranes were formed using combinations of phosphatidylcholine, phosphatidylglycerol (PG), and S. aureus-derived lipoteichoic acid (LTA).
34165952	9	0	theme	monomer	1739:1745	arg1	gels					1761:1764	the higher monomer concentration gels	1728:1764	the higher monomer concentration gels	1728:1764	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	10	1	theme	dextran-borate-glycoprotein	1901:1927	arg1	complexation					1929:1940	the dextran-borate-glycoprotein complexation	1897:1940	the dextran-borate-glycoprotein complexation	1897:1940	This latter gel took advantage of the dextran-borate-glycoprotein complexation.
34165952	6	2	theme	greatest	1178:1185	arg1	window					1198:1203	the greatest separation window	1174:1203	the greatest separation window	1174:1203	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	2	3	theme	cross-linked	363:374	arg1	matrix					399:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	6	4	theme	former	1312:1317	arg1	composition					1319:1329	the former composition	1308:1329	the former composition in the direction opposite to SDS-protein complex migration	1308:1388	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	6	5	theme	analysis	1119:1126	arg1	time					1128:1131	the fastest analysis time	1107:1131	the fastest analysis time	1107:1131	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	8	6	dep	differences	1602:1612	arg1	due					1615:1617	due	1615:1617	due	1615:1617	A combination of molecular weight and shape selectivity as well as, to a lesser extent, surface charge density differences (due to glycosylation on the heavy chain) influenced migration.
34165952	8	7	theme	molecular	1508:1516	arg1	weight					1518:1523	molecular weight	1508:1523	molecular weight	1508:1523	A combination of molecular weight and shape selectivity as well as, to a lesser extent, surface charge density differences (due to glycosylation on the heavy chain) influenced migration.
34165952	3	8	theme	polymer	580:586	arg1	chains					588:593	the semirigid dextran polymer chains	558:593	the semirigid dextran polymer chains	558:593	Transient borate cross-linking of the semirigid dextran polymer chains leads to a high-resolution separation gel for SDS-protein complexes.
34165952	4	9	theme	borate	824:829	arg1	cross-linker					831:842	borate cross-linker	824:842	borate cross-linker (2 and 4%) concentrations	824:868	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	4	9	theme	borate	824:829	arg1	%					852:852	2 and 4%	845:852	2 and 4%	845:852	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	10	10	theme	complexation	1929:1940	arg1	advantage					1884:1892	advantage	1884:1892	advantage of the dextran-borate-glycoprotein complexation	1884:1940	This latter gel took advantage of the dextran-borate-glycoprotein complexation.
34165952	2	11	theme	capillary	304:312	arg1	electrophoresis					318:332	Sodium dodecyl sulfate capillary gel electrophoresis	281:332	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix	281:404	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	2	11	theme	capillary	304:312	arg1	SDS-CGE					335:341	SDS-CGE	335:341	SDS-CGE	335:341	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	11	12	theme	time	2217:2220	arg1	reproducibilities					2222:2238	gel-to-gel migration time reproducibilities	2196:2238	gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD))	2196:2281	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	11	12	theme	time	2217:2220	arg1	%					2246:2246	<0.96% relative standard deviation (RSD)	2241:2280	<0.96% relative standard deviation (RSD)	2241:2280	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	5	13	dep	225	977:979	arg1	to					974:975	to	974:975	to	974:975	Ferguson plots were analyzed for a mixture of protein standards with molecular weights ranging from 20 to 225 kDa, and the resulting nonlinear concave curves pointed to nonclassical sieving behavior.
34165952	8	14	theme	surface	1579:1585	arg1	differences					1602:1612	surface charge density differences	1579:1612	surface charge density differences (due to glycosylation on the heavy chain)	1579:1654	A combination of molecular weight and shape selectivity as well as, to a lesser extent, surface charge density differences (due to glycosylation on the heavy chain) influenced migration.
34165952	1	15	theme	protein	189:195	arg1	therapeutics					197:208	new, innovative protein therapeutics	173:208	new, innovative protein therapeutics	173:208	Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques.
34165952	6	16	dep	higher	1211:1216	arg1	due					1248:1250	due	1248:1250	due	1248:1250	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	6	17	theme	B	1089:1089	arg1	gel					1091:1093	the 2% D/4% B gel	1077:1093	the 2% D/4% B gel	1077:1093	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	12	18	theme	used	2295:2298	arg1	gel					2322:2324	The widely used 10% dextran/4% borate gel	2284:2324	The widely used 10% dextran/4% borate gel	2284:2324	The widely used 10% dextran/4% borate gel represents a good screening option, which can then be followed by a modified composition, optimized for a specific separation as necessary.
34165952	5	19	with	mixture	906:912	arg1	weights					950:956	molecular weights	940:956	molecular weights ranging from 20 to 225 kDa	940:983	Ferguson plots were analyzed for a mixture of protein standards with molecular weights ranging from 20 to 225 kDa, and the resulting nonlinear concave curves pointed to nonclassical sieving behavior.
34165952	3	20	theme	borate	534:539	arg1	cross-linking					541:553	Transient borate cross-linking	524:553	Transient borate cross-linking of the semirigid dextran polymer chains	524:593	Transient borate cross-linking of the semirigid dextran polymer chains leads to a high-resolution separation gel for SDS-protein complexes.
34165952	6	21	theme	complex	1372:1378	arg1	migration					1380:1388	SDS-protein complex migration	1360:1388	SDS-protein complex migration	1360:1388	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	8	22	theme	density	1594:1600	arg1	differences					1602:1612	surface charge density differences	1579:1612	surface charge density differences (due to glycosylation on the heavy chain)	1579:1654	A combination of molecular weight and shape selectivity as well as, to a lesser extent, surface charge density differences (due to glycosylation on the heavy chain) influenced migration.
34165952	9	23	dep	B	1860:1860	arg1	%					1853:1853	%	1853:1853	%	1853:1853	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	6	24	theme	B	1147:1147	arg1	gel					1149:1151	the 10% D/2% B gel	1134:1151	the 10% D/2% B gel	1134:1151	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	11	25	theme	specific	2109:2116	arg1	modalities					2136:2145	specific biopharmaceutical modalities	2109:2145	specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD))	2109:2281	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	6	26	theme	electroosmotic	1285:1298	arg1	flow					1300:1303	the electroosmotic flow	1281:1303	the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration	1281:1388	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	6	27	theme	D/2	1142:1144	arg1	gel					1149:1151	the 10% D/2% B gel	1134:1151	the 10% D/2% B gel	1134:1151	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	9	28	theme	dilute	1825:1830	arg1	gel					1832:1834	a more dilute gel	1818:1834	a more dilute gel	1818:1834	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	9	28	theme	dilute	1825:1830	arg1	B					1860:1860	as low as 2% D/2% B	1842:1860	as low as 2% D/2% B	1842:1860	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	3	29	theme	separation	622:631	arg1	gel					633:635	a high-resolution separation gel	604:635	a high-resolution separation gel for SDS-protein complexes	604:661	Transient borate cross-linking of the semirigid dextran polymer chains leads to a high-resolution separation gel for SDS-protein complexes.
34165952	6	30	theme	10	1138:1139	arg1	%					1140:1140	%	1140:1140	%	1140:1140	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	4	31	theme	various	755:761	arg1	%					817:817	2, 5, 7.5, and 10%	800:817	2, 5, 7.5, and 10%	800:817	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	4	31	theme	various	755:761	arg1	formulations					767:778	various gel formulations	755:778	various gel formulations of dextran monomer (2, 5, 7.5, and 10%)	755:818	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	4	32	theme	dextran	783:789	arg1	monomer					791:797	dextran monomer	783:797	dextran monomer	783:797	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	5	33	theme	nonlinear	1004:1012	arg1	curves					1022:1027	the resulting nonlinear concave curves	990:1027	the resulting nonlinear concave curves	990:1027	Ferguson plots were analyzed for a mixture of protein standards with molecular weights ranging from 20 to 225 kDa, and the resulting nonlinear concave curves pointed to nonclassical sieving behavior.
34165952	2	34	theme	dodecyl	288:294	arg1	electrophoresis					318:332	Sodium dodecyl sulfate capillary gel electrophoresis	281:332	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix	281:404	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	2	34	theme	dodecyl	288:294	arg1	SDS-CGE					335:341	SDS-CGE	335:341	SDS-CGE	335:341	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	7	35	theme	antibody	1464:1471	arg1	separation					1425:1434	SDS-CGE separation	1417:1434	SDS-CGE separation of a therapeutic monoclonal antibody and its subunits	1417:1488	The study then focused on SDS-CGE separation of a therapeutic monoclonal antibody and its subunits.
34165952	12	36	theme	screening	2344:2352	arg1	option					2354:2359	a good screening option	2337:2359	a good screening option	2337:2359	The widely used 10% dextran/4% borate gel represents a good screening option, which can then be followed by a modified composition, optimized for a specific separation as necessary.
34165952	4	37	theme	gel	724:726	arg1	basis					707:711	the migration and separation basis	678:711	basis	707:711	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	0	38	theme	SDS	70:72	arg1	Proteins					74:81	SDS Proteins	70:81	SDS Proteins	70:81	Fundamentals of Capillary Electrophoretic Migration and Separation of SDS Proteins in Borate Cross-Linked Dextran Gels.
34165952	11	39	theme	monomer	1994:2000	arg1	ratios					2043:2048	the dextran (monomer) and borate (cross-linker) concentration ratios	1981:2048	the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix	1981:2070	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	8	40	theme	heavy	1643:1647	arg1	chain					1649:1653	the heavy chain	1639:1653	the heavy chain	1639:1653	A combination of molecular weight and shape selectivity as well as, to a lesser extent, surface charge density differences (due to glycosylation on the heavy chain) influenced migration.
34165952	7	41	theme	therapeutic	1441:1451	arg1	antibody					1464:1471	a therapeutic monoclonal antibody	1439:1471	a therapeutic monoclonal antibody	1439:1471	The study then focused on SDS-CGE separation of a therapeutic monoclonal antibody and its subunits.
34165952	11	42	theme	concentration	2029:2041	arg1	ratios					2043:2048	the dextran (monomer) and borate (cross-linker) concentration ratios	1981:2048	the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix	1981:2070	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	6	43	from	flow	1300:1303	arg1	direction					1338:1346	the direction	1334:1346	the direction opposite to SDS-protein complex migration	1334:1388	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	12	44	theme	specific	2432:2439	arg1	separation					2441:2450	a specific separation	2430:2450	a specific separation as necessary	2430:2463	The widely used 10% dextran/4% borate gel represents a good screening option, which can then be followed by a modified composition, optimized for a specific separation as necessary.
34165952	11	45	dep	%	2246:2246	arg1	RSD					2277:2279	RSD	2277:2279	RSD	2277:2279	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	11	45	dep	%	2246:2246	arg1	deviation					2266:2274	relative standard deviation	2248:2274	<0.96% relative standard deviation (RSD)	2241:2280	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	10	46	theme	latter	1868:1873	arg1	gel					1875:1877	This latter gel	1863:1877	This latter gel	1863:1877	This latter gel took advantage of the dextran-borate-glycoprotein complexation.
34165952	5	47	theme	Ferguson	871:878	arg1	plots					880:884	Ferguson plots	871:884	Ferguson plots	871:884	Ferguson plots were analyzed for a mixture of protein standards with molecular weights ranging from 20 to 225 kDa, and the resulting nonlinear concave curves pointed to nonclassical sieving behavior.
34165952	8	48	gly	glycosylation	1622:1634	arg1	chain					1649:1653	the heavy chain	1639:1653	the heavy chain	1639:1653	A combination of molecular weight and shape selectivity as well as, to a lesser extent, surface charge density differences (due to glycosylation on the heavy chain) influenced migration.
34165952	2	49	from	analysis	453:460	arg1	release					507:513	release	507:513	release	507:513	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	2	49	from	analysis	453:460	arg1	manufacturing					489:501	manufacturing	489:501	manufacturing	489:501	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	12	50	theme	modified	2394:2401	arg1	composition					2403:2413	a modified composition	2392:2413	a modified composition	2392:2413	The widely used 10% dextran/4% borate gel represents a good screening option, which can then be followed by a modified composition, optimized for a specific separation as necessary.
34165952	0	51	theme	Cross-Linked	93:104	arg1	Gels					114:117	Borate Cross-Linked Dextran Gels	86:117	Borate Cross-Linked Dextran Gels	86:117	Fundamentals of Capillary Electrophoretic Migration and Separation of SDS Proteins in Borate Cross-Linked Dextran Gels.
34165952	5	52	theme	sieving	1053:1059	arg1	behavior					1061:1068	nonclassical sieving behavior	1040:1068	nonclassical sieving behavior	1040:1068	Ferguson plots were analyzed for a mixture of protein standards with molecular weights ranging from 20 to 225 kDa, and the resulting nonlinear concave curves pointed to nonclassical sieving behavior.
34165952	7	53	theme	SDS-CGE	1417:1423	arg1	separation					1425:1434	SDS-CGE separation	1417:1434	SDS-CGE separation of a therapeutic monoclonal antibody and its subunits	1417:1488	The study then focused on SDS-CGE separation of a therapeutic monoclonal antibody and its subunits.
34165952	11	54	theme	sieving	2057:2063	arg1	matrix					2065:2070	the sieving matrix	2053:2070	the sieving matrix	2053:2070	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	9	55	theme	%	1858:1858	arg1	gel					1832:1834	a more dilute gel	1818:1834	a more dilute gel	1818:1834	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	9	55	theme	%	1858:1858	arg1	B					1860:1860	as low as 2% D/2% B	1842:1860	as low as 2% D/2% B	1842:1860	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	6	56	theme	%	1234:1234	arg1	gel					1243:1245	the 10% D/4% B gel	1228:1245	the 10% D/4% B gel	1228:1245	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	11	57	theme	standard	2257:2264	arg1	RSD					2277:2279	RSD	2277:2279	RSD	2277:2279	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	11	57	theme	standard	2257:2264	arg1	deviation					2266:2274	relative standard deviation	2248:2274	<0.96% relative standard deviation (RSD)	2241:2280	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	2	58	theme	separation	388:397	arg1	matrix					399:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	6	59	from	increase	1269:1276	arg1	flow					1300:1303	the electroosmotic flow	1281:1303	the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration	1281:1388	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	11	60	theme	borate	2007:2012	arg1	concentration					2029:2041	dextran (monomer) and borate (cross-linker) concentration	1985:2041	concentration	2029:2041	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	2	61	theme	consistency	441:451	arg1	analysis					453:460	rapid consistency analysis	435:460	rapid consistency analysis of therapeutic proteins in manufacturing and release testing	435:521	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	2	62	theme	Sodium	281:286	arg1	electrophoresis					318:332	Sodium dodecyl sulfate capillary gel electrophoresis	281:332	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix	281:404	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	2	62	theme	Sodium	281:286	arg1	SDS-CGE					335:341	SDS-CGE	335:341	SDS-CGE	335:341	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	1	63	dep	development	143:153	arg1	the					139:141	the	139:141	the	139:141	Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques.
34165952	0	64	theme	Capillary	16:24	arg1	Migration					42:50	Capillary Electrophoretic Migration	16:50	Capillary Electrophoretic Migration	16:50	Fundamentals of Capillary Electrophoretic Migration and Separation of SDS Proteins in Borate Cross-Linked Dextran Gels.
34165952	5	65	theme	protein	917:923	arg1	standards					925:933	protein standards	917:933	protein standards	917:933	Ferguson plots were analyzed for a mixture of protein standards with molecular weights ranging from 20 to 225 kDa, and the resulting nonlinear concave curves pointed to nonclassical sieving behavior.
34165952	11	66	theme	cross-linker	2015:2026	arg1	concentration					2029:2041	dextran (monomer) and borate (cross-linker) concentration	1985:2041	concentration	2029:2041	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	0	67	theme	Migration	42:50	arg1	Fundamentals					0:11	Fundamentals	0:11	Fundamentals of Capillary Electrophoretic Migration and Separation of SDS Proteins in Borate Cross-Linked Dextran Gels.	0:118	Fundamentals of Capillary Electrophoretic Migration and Separation of SDS Proteins in Borate Cross-Linked Dextran Gels.
34165952	2	68	theme	proteins	477:484	arg1	analysis					453:460	rapid consistency analysis	435:460	rapid consistency analysis of therapeutic proteins in manufacturing and release testing	435:521	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	1	69	dep	new	173:175	arg1	innovative					178:187	innovative	178:187	innovative	178:187	Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques.
34165952	0	70	theme	Separation	56:65	arg1	Fundamentals					0:11	Fundamentals	0:11	Fundamentals of Capillary Electrophoretic Migration and Separation of SDS Proteins in Borate Cross-Linked Dextran Gels.	0:118	Fundamentals of Capillary Electrophoretic Migration and Separation of SDS Proteins in Borate Cross-Linked Dextran Gels.
34165952	6	71	theme	%	1082:1082	arg1	gel					1091:1093	the 2% D/4% B gel	1077:1093	the 2% D/4% B gel	1077:1093	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	6	72	theme	opposite	1348:1355	arg1	direction					1338:1346	the direction	1334:1346	the direction opposite to SDS-protein complex migration	1334:1388	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	1	73	theme	adjustable	228:237	arg1	techniques					269:278	rapid and adjustable high-resolution bioseparation techniques	218:278	rapid and adjustable high-resolution bioseparation techniques	218:278	Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques.
34165952	3	74	theme	semirigid	562:570	arg1	chains					588:593	the semirigid dextran polymer chains	558:593	the semirigid dextran polymer chains	558:593	Transient borate cross-linking of the semirigid dextran polymer chains leads to a high-resolution separation gel for SDS-protein complexes.
34165952	11	75	theme	gel-to-gel	2196:2205	arg1	reproducibilities					2222:2238	gel-to-gel migration time reproducibilities	2196:2238	gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD))	2196:2281	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	11	75	theme	gel-to-gel	2196:2205	arg1	%					2246:2246	<0.96% relative standard deviation (RSD)	2241:2280	<0.96% relative standard deviation (RSD)	2241:2280	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	2	76	theme	D	385:385	arg1	matrix					399:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	8	77	theme	shape	1529:1533	arg1	selectivity					1535:1545	shape selectivity	1529:1545	shape selectivity	1529:1545	A combination of molecular weight and shape selectivity as well as, to a lesser extent, surface charge density differences (due to glycosylation on the heavy chain) influenced migration.
34165952	1	78	theme	bioseparation	255:267	arg1	techniques					269:278	rapid and adjustable high-resolution bioseparation techniques	218:278	rapid and adjustable high-resolution bioseparation techniques	218:278	Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques.
34165952	9	79	theme	molecular	1686:1694	arg1	weight					1696:1701	Greater molecular weight	1678:1701	Greater molecular weight selectivity	1678:1713	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	6	80	from	composition	1319:1329	arg1	direction					1338:1346	the direction	1334:1346	the direction opposite to SDS-protein complex migration	1334:1388	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	9	81	theme	higher	1732:1737	arg1	gels					1761:1764	the higher monomer concentration gels	1728:1764	the higher monomer concentration gels	1728:1764	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	6	82	theme	separation	1187:1196	arg1	window					1198:1203	the greatest separation window	1174:1203	the greatest separation window	1174:1203	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	2	83	theme	dextran	376:382	arg1	matrix					399:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	6	84	theme	composition	1319:1329	arg1	flow					1300:1303	the electroosmotic flow	1281:1303	the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration	1281:1388	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	9	85	theme	concentration	1747:1759	arg1	gels					1761:1764	the higher monomer concentration gels	1728:1764	the higher monomer concentration gels	1728:1764	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	3	86	theme	dextran	572:578	arg1	chains					588:593	the semirigid dextran polymer chains	558:593	the semirigid dextran polymer chains	558:593	Transient borate cross-linking of the semirigid dextran polymer chains leads to a high-resolution separation gel for SDS-protein complexes.
34165952	6	87	theme	fastest	1111:1117	arg1	time					1128:1131	the fastest analysis time	1107:1131	the fastest analysis time	1107:1131	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	12	88	theme	borate	2315:2320	arg1	gel					2322:2324	The widely used 10% dextran/4% borate gel	2284:2324	The widely used 10% dextran/4% borate gel	2284:2324	The widely used 10% dextran/4% borate gel represents a good screening option, which can then be followed by a modified composition, optimized for a specific separation as necessary.
34165952	2	89	link	cross-linked	363:374	arg1	matrix					399:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	2	90	theme	gel	314:316	arg1	electrophoresis					318:332	Sodium dodecyl sulfate capillary gel electrophoresis	281:332	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix	281:404	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	2	90	theme	gel	314:316	arg1	SDS-CGE					335:341	SDS-CGE	335:341	SDS-CGE	335:341	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	1	91	theme	new	173:175	arg1	therapeutics					197:208	new, innovative protein therapeutics	173:208	new, innovative protein therapeutics	173:208	Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques.
34165952	9	92	theme	weight	1696:1701	arg1	selectivity					1703:1713	Greater molecular weight selectivity	1678:1713	Greater molecular weight selectivity	1678:1713	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	11	93	theme	dextran	1985:1991	arg1	monomer					1994:2000	dextran (monomer) and borate (cross-linker) concentration	1985:2041	monomer	1994:2000	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	9	94	theme	improved	1773:1780	arg1	glycoselectivity					1782:1797	improved glycoselectivity	1773:1797	improved glycoselectivity	1773:1797	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	4	95	theme	separation	696:705	arg1	basis					707:711	the migration and separation basis	678:711	basis	707:711	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	8	96	theme	lesser	1564:1569	arg1	extent					1571:1576	a lesser extent	1562:1576	a lesser extent	1562:1576	A combination of molecular weight and shape selectivity as well as, to a lesser extent, surface charge density differences (due to glycosylation on the heavy chain) influenced migration.
34165952	4	97	theme	cross-linker	831:842	arg1	concentrations					855:868	borate cross-linker (2 and 4%) concentrations	824:868	borate cross-linker (2 and 4%) concentrations	824:868	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	11	98	theme	biopharmaceutical	2118:2134	arg1	modalities					2136:2145	specific biopharmaceutical modalities	2109:2145	specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD))	2109:2281	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	6	99	theme	10	1232:1233	arg1	%					1234:1234	%	1234:1234	%	1234:1234	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	3	100	theme	chains	588:593	arg1	cross-linking					541:553	Transient borate cross-linking	524:553	Transient borate cross-linking of the semirigid dextran polymer chains	524:593	Transient borate cross-linking of the semirigid dextran polymer chains leads to a high-resolution separation gel for SDS-protein complexes.
34165952	1	101	theme	therapeutics	197:208	arg1	production					159:168	production	159:168	production	159:168	Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques.
34165952	1	101	theme	therapeutics	197:208	arg1	development					143:153	development	143:153	development	143:153	Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques.
34165952	2	102	from	release	507:513	arg1	analysis					453:460	rapid consistency analysis	435:460	rapid consistency analysis of therapeutic proteins in manufacturing and release testing	435:521	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	6	103	theme	%	1087:1087	arg1	gel					1091:1093	the 2% D/4% B gel	1077:1093	the 2% D/4% B gel	1077:1093	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	12	104	theme	dextran/4	2304:2312	arg1	%					2302:2302	%	2302:2302	%	2302:2302	The widely used 10% dextran/4% borate gel represents a good screening option, which can then be followed by a modified composition, optimized for a specific separation as necessary.
34165952	12	105	theme	10	2300:2301	arg1	%					2302:2302	%	2302:2302	%	2302:2302	The widely used 10% dextran/4% borate gel represents a good screening option, which can then be followed by a modified composition, optimized for a specific separation as necessary.
34165952	3	106	theme	Transient	524:532	arg1	cross-linking					541:553	Transient borate cross-linking	524:553	Transient borate cross-linking of the semirigid dextran polymer chains	524:593	Transient borate cross-linking of the semirigid dextran polymer chains leads to a high-resolution separation gel for SDS-protein complexes.
34165952	6	107	theme	SDS-protein	1360:1370	arg1	migration					1380:1388	SDS-protein complex migration	1360:1388	SDS-protein complex migration	1360:1388	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	1	108	theme	rapid	218:222	arg1	techniques					269:278	rapid and adjustable high-resolution bioseparation techniques	218:278	rapid and adjustable high-resolution bioseparation techniques	218:278	Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques.
34165952	7	109	theme	subunits	1481:1488	arg1	separation					1425:1434	SDS-CGE separation	1417:1434	SDS-CGE separation of a therapeutic monoclonal antibody and its subunits	1417:1488	The study then focused on SDS-CGE separation of a therapeutic monoclonal antibody and its subunits.
34165952	6	110	theme	%	1145:1145	arg1	gel					1149:1151	the 10% D/2% B gel	1134:1151	the 10% D/2% B gel	1134:1151	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	4	111	theme	migration	682:690	arg1	basis					707:711	the migration and separation basis	678:711	basis	707:711	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	6	112	theme	B	1241:1241	arg1	gel					1243:1245	the 10% D/4% B gel	1228:1245	the 10% D/4% B gel	1228:1245	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	6	113	theme	higher	1211:1216	arg1	window					1198:1203	the greatest separation window	1174:1203	the greatest separation window	1174:1203	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	5	114	theme	nonclassical	1040:1051	arg1	behavior					1061:1068	nonclassical sieving behavior	1040:1068	nonclassical sieving behavior	1040:1068	Ferguson plots were analyzed for a mixture of protein standards with molecular weights ranging from 20 to 225 kDa, and the resulting nonlinear concave curves pointed to nonclassical sieving behavior.
34165952	3	115	theme	high-resolution	606:620	arg1	gel					633:635	a high-resolution separation gel	604:635	a high-resolution separation gel for SDS-protein complexes	604:661	Transient borate cross-linking of the semirigid dextran polymer chains leads to a high-resolution separation gel for SDS-protein complexes.
34165952	1	116	theme	Recent	120:125	arg1	progress					127:134	Recent progress	120:134	Recent progress in the development and production of new, innovative protein therapeutics	120:208	Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques.
34165952	0	117	from	Fundamentals	0:11	arg1	Gels					114:117	Borate Cross-Linked Dextran Gels	86:117	Borate Cross-Linked Dextran Gels	86:117	Fundamentals of Capillary Electrophoretic Migration and Separation of SDS Proteins in Borate Cross-Linked Dextran Gels.
34165952	6	118	theme	%	1140:1140	arg1	gel					1149:1151	the 10% D/2% B gel	1134:1151	the 10% D/2% B gel	1134:1151	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	4	119	theme	present	733:739	arg1	work					741:744	the present work	729:744	the present work	729:744	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	5	120	theme	resulting	994:1002	arg1	curves					1022:1027	the resulting nonlinear concave curves	990:1027	the resulting nonlinear concave curves	990:1027	Ferguson plots were analyzed for a mixture of protein standards with molecular weights ranging from 20 to 225 kDa, and the resulting nonlinear concave curves pointed to nonclassical sieving behavior.
34165952	2	121	theme	sulfate	296:302	arg1	electrophoresis					318:332	Sodium dodecyl sulfate capillary gel electrophoresis	281:332	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix	281:404	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	2	121	theme	sulfate	296:302	arg1	SDS-CGE					335:341	SDS-CGE	335:341	SDS-CGE	335:341	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	7	122	theme	monoclonal	1453:1462	arg1	antibody					1464:1471	a therapeutic monoclonal antibody	1439:1471	a therapeutic monoclonal antibody	1439:1471	The study then focused on SDS-CGE separation of a therapeutic monoclonal antibody and its subunits.
34165952	0	123	theme	Proteins	74:81	arg1	Separation					56:65	Separation	56:65	Separation of SDS Proteins	56:81	Fundamentals of Capillary Electrophoretic Migration and Separation of SDS Proteins in Borate Cross-Linked Dextran Gels.
34165952	0	123	theme	Proteins	74:81	arg1	Migration					42:50	Capillary Electrophoretic Migration	16:50	Capillary Electrophoretic Migration	16:50	Fundamentals of Capillary Electrophoretic Migration and Separation of SDS Proteins in Borate Cross-Linked Dextran Gels.
34165952	5	124	theme	concave	1014:1020	arg1	curves					1022:1027	the resulting nonlinear concave curves	990:1027	the resulting nonlinear concave curves	990:1027	Ferguson plots were analyzed for a mixture of protein standards with molecular weights ranging from 20 to 225 kDa, and the resulting nonlinear concave curves pointed to nonclassical sieving behavior.
34165952	3	125	theme	SDS-protein	641:651	arg1	complexes					653:661	SDS-protein complexes	641:661	SDS-protein complexes	641:661	Transient borate cross-linking of the semirigid dextran polymer chains leads to a high-resolution separation gel for SDS-protein complexes.
34165952	12	126	dep	gel	2322:2324	arg1	%					2313:2313	%	2313:2313	%	2313:2313	The widely used 10% dextran/4% borate gel represents a good screening option, which can then be followed by a modified composition, optimized for a specific separation as necessary.
34165952	8	127	theme	weight	1518:1523	arg1	combination					1493:1503	A combination	1491:1503	A combination of molecular weight and shape selectivity	1491:1545	A combination of molecular weight and shape selectivity as well as, to a lesser extent, surface charge density differences (due to glycosylation on the heavy chain) influenced migration.
34165952	4	128	theme	D/B	720:722	arg1	gel					724:726	the D/B gel	716:726	the D/B gel	716:726	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	6	129	theme	%	1239:1239	arg1	gel					1243:1245	the 10% D/4% B gel	1228:1245	the 10% D/4% B gel	1228:1245	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	0	130	theme	Borate	86:91	arg1	Gels					114:117	Borate Cross-Linked Dextran Gels	86:117	Borate Cross-Linked Dextran Gels	86:117	Fundamentals of Capillary Electrophoretic Migration and Separation of SDS Proteins in Borate Cross-Linked Dextran Gels.
34165952	12	131	dep	%	2313:2313	arg1	%					2302:2302	%	2302:2302	%	2302:2302	The widely used 10% dextran/4% borate gel represents a good screening option, which can then be followed by a modified composition, optimized for a specific separation as necessary.
34165952	0	132	theme	Dextran	106:112	arg1	Gels					114:117	Borate Cross-Linked Dextran Gels	86:117	Borate Cross-Linked Dextran Gels	86:117	Fundamentals of Capillary Electrophoretic Migration and Separation of SDS Proteins in Borate Cross-Linked Dextran Gels.
34165952	2	133	dep	manufacturing	489:501	arg1	testing					515:521	testing	515:521	testing	515:521	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	11	134	theme	migration	2207:2215	arg1	reproducibilities					2222:2238	gel-to-gel migration time reproducibilities	2196:2238	gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD))	2196:2281	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	11	134	theme	migration	2207:2215	arg1	%					2246:2246	<0.96% relative standard deviation (RSD)	2241:2280	<0.96% relative standard deviation (RSD)	2241:2280	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	5	135	theme	standards	925:933	arg1	mixture					906:912	a mixture	904:912	a mixture of protein standards with molecular weights ranging from 20 to 225 kDa	904:983	Ferguson plots were analyzed for a mixture of protein standards with molecular weights ranging from 20 to 225 kDa, and the resulting nonlinear concave curves pointed to nonclassical sieving behavior.
34165952	2	136	from	proteins	477:484	arg1	release					507:513	release	507:513	release	507:513	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	2	136	from	proteins	477:484	arg1	manufacturing					489:501	manufacturing	489:501	manufacturing	489:501	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	10	137	gly	dextran-borate-glycoprotein	1901:1927	arg1	dextran-borate-glycoprotein					1901:1927	dextran-borate-glycoprotein	1901:1927	dextran-borate-glycoprotein	1901:1927	This latter gel took advantage of the dextran-borate-glycoprotein complexation.
34165952	9	138	theme	D/2	1855:1857	arg1	gel					1832:1834	a more dilute gel	1818:1834	a more dilute gel	1818:1834	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	9	138	theme	D/2	1855:1857	arg1	B					1860:1860	as low as 2% D/2% B	1842:1860	as low as 2% D/2% B	1842:1860	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	4	139	theme	monomer	791:797	arg1	%					817:817	2, 5, 7.5, and 10%	800:817	2, 5, 7.5, and 10%	800:817	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	4	139	theme	monomer	791:797	arg1	formulations					767:778	various gel formulations	755:778	various gel formulations of dextran monomer (2, 5, 7.5, and 10%)	755:818	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	4	139	theme	monomer	791:797	arg1	concentrations					855:868	borate cross-linker (2 and 4%) concentrations	824:868	borate cross-linker (2 and 4%) concentrations	824:868	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	6	140	theme	D/4	1236:1238	arg1	%					1239:1239	%	1239:1239	%	1239:1239	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	5	141	theme	molecular	940:948	arg1	weights					950:956	molecular weights	940:956	molecular weights ranging from 20 to 225 kDa	940:983	Ferguson plots were analyzed for a mixture of protein standards with molecular weights ranging from 20 to 225 kDa, and the resulting nonlinear concave curves pointed to nonclassical sieving behavior.
34165952	11	142	theme	matrix	2065:2070	arg1	ratios					2043:2048	the dextran (monomer) and borate (cross-linker) concentration ratios	1981:2048	the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix	1981:2070	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	2	143	from	manufacturing	489:501	arg1	analysis					453:460	rapid consistency analysis	435:460	rapid consistency analysis of therapeutic proteins in manufacturing and release testing	435:521	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	11	144	theme	relative	2248:2255	arg1	RSD					2277:2279	RSD	2277:2279	RSD	2277:2279	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	11	144	theme	relative	2248:2255	arg1	deviation					2266:2274	relative standard deviation	2248:2274	<0.96% relative standard deviation (RSD)	2241:2280	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	4	145	theme	gel	763:765	arg1	%					817:817	2, 5, 7.5, and 10%	800:817	2, 5, 7.5, and 10%	800:817	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	4	145	theme	gel	763:765	arg1	formulations					767:778	various gel formulations	755:778	various gel formulations of dextran monomer (2, 5, 7.5, and 10%)	755:818	To understand the migration and separation basis of the D/B gel, the present work explores various gel formulations of dextran monomer (2, 5, 7.5, and 10%) and borate cross-linker (2 and 4%) concentrations.
34165952	0	146	theme	Electrophoretic	26:40	arg1	Migration					42:50	Capillary Electrophoretic Migration	16:50	Capillary Electrophoretic Migration	16:50	Fundamentals of Capillary Electrophoretic Migration and Separation of SDS Proteins in Borate Cross-Linked Dextran Gels.
34165952	1	147	from	progress	127:134	arg1	production					159:168	production	159:168	production	159:168	Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques.
34165952	1	147	from	progress	127:134	arg1	development					143:153	development	143:153	development	143:153	Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques.
34165952	2	148	theme	rapid	435:439	arg1	analysis					453:460	rapid consistency analysis	435:460	rapid consistency analysis of therapeutic proteins in manufacturing and release testing	435:521	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	8	149	theme	charge	1587:1592	arg1	differences					1602:1612	surface charge density differences	1579:1612	surface charge density differences (due to glycosylation on the heavy chain)	1579:1654	A combination of molecular weight and shape selectivity as well as, to a lesser extent, surface charge density differences (due to glycosylation on the heavy chain) influenced migration.
34165952	6	150	from	direction	1338:1346	arg1	flow					1300:1303	the electroosmotic flow	1281:1303	the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration	1281:1388	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	9	151	dep	%	1853:1853	arg1	2					1852:1852	2	1852:1852	2	1852:1852	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	9	152	theme	Greater	1678:1684	arg1	weight					1696:1701	Greater molecular weight	1678:1701	Greater molecular weight selectivity	1678:1713	Greater molecular weight selectivity occurred for the higher monomer concentration gels, while improved glycoselectivity was obtained using a more dilute gel, even as low as 2% D/2% B.
34165952	6	153	theme	significant	1257:1267	arg1	increase					1269:1276	a significant increase	1255:1276	a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration	1255:1388	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	11	154	with	modalities	2136:2145	arg1	column-to-column					2162:2177	excellent column-to-column	2152:2177	excellent column-to-column	2152:2177	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	11	154	with	modalities	2136:2145	arg1	reproducibilities					2222:2238	gel-to-gel migration time reproducibilities	2196:2238	gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD))	2196:2281	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	11	154	with	modalities	2136:2145	arg1	run-to-run					2180:2189	run-to-run	2180:2189	run-to-run	2180:2189	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	11	154	with	modalities	2136:2145	arg1	%					2246:2246	<0.96% relative standard deviation (RSD)	2241:2280	<0.96% relative standard deviation (RSD)	2241:2280	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
34165952	6	155	theme	D/4	1084:1086	arg1	%					1087:1087	%	1087:1087	%	1087:1087	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	2	156	theme	therapeutic	465:475	arg1	proteins					477:484	therapeutic proteins	465:484	therapeutic proteins in manufacturing and release testing	465:521	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	2	157	theme	B	360:360	arg1	matrix					399:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	6	158	theme	2	1081:1081	arg1	%					1082:1082	%	1082:1082	%	1082:1082	While the 2% D/4% B gel resulted in the fastest analysis time, the 10% D/2% B gel was found to produce the greatest separation window, even higher than with the 10% D/4% B gel, due to a significant increase in the electroosmotic flow of the former composition in the direction opposite to SDS-protein complex migration.
34165952	2	159	theme	borate	352:357	arg1	matrix					399:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	a borate (B) cross-linked dextran (D) separation matrix	350:404	Sodium dodecyl sulfate capillary gel electrophoresis (SDS-CGE) using a borate (B) cross-linked dextran (D) separation matrix is widely employed today for rapid consistency analysis of therapeutic proteins in manufacturing and release testing.
34165952	8	160	theme	selectivity	1535:1545	arg1	combination					1493:1503	A combination	1491:1503	A combination of molecular weight and shape selectivity	1491:1545	A combination of molecular weight and shape selectivity as well as, to a lesser extent, surface charge density differences (due to glycosylation on the heavy chain) influenced migration.
34165952	1	161	theme	high-resolution	239:253	arg1	techniques					269:278	rapid and adjustable high-resolution bioseparation techniques	218:278	rapid and adjustable high-resolution bioseparation techniques	218:278	Recent progress in the development and production of new, innovative protein therapeutics require rapid and adjustable high-resolution bioseparation techniques.
34165952	8	162	from	glycosylation	1622:1634	arg1	chain					1649:1653	the heavy chain	1639:1653	the heavy chain	1639:1653	A combination of molecular weight and shape selectivity as well as, to a lesser extent, surface charge density differences (due to glycosylation on the heavy chain) influenced migration.
34165952	12	163	theme	good	2339:2342	arg1	option					2354:2359	a good screening option	2337:2359	a good screening option	2337:2359	The widely used 10% dextran/4% borate gel represents a good screening option, which can then be followed by a modified composition, optimized for a specific separation as necessary.
34165952	11	164	theme	excellent	2152:2160	arg1	column-to-column					2162:2177	excellent column-to-column	2152:2177	excellent column-to-column	2152:2177	The study revealed that by modulating the dextran (monomer) and borate (cross-linker) concentration ratios of the sieving matrix, one can optimize the separation for specific biopharmaceutical modalities with excellent column-to-column, run-to-run, and gel-to-gel migration time reproducibilities (<0.96% relative standard deviation (RSD)).
32096976	4	0	theme	propulsion	675:684	arg1	force					686:690	a high propulsion force	668:690	a high propulsion force	668:690	In this biohybrid system, the sperm flagellum provides a high propulsion force while the synthetic microstructure serves for magnetic guidance and cargo transport.
32096976	1	1	theme	complex	175:181	arg1	environments					194:205	complex biological environments	175:205	complex biological environments	175:205	Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo delivery in complex biological environments.
32096976	5	2	theme	anticoagulant	978:990	arg1	agents					992:997	potential anticoagulant agents	968:997	potential anticoagulant agents	968:997	Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
32096976	5	3	theme	interest	947:954	arg1	area					939:942	the area	935:942	the area of interest	935:954	Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
32096976	5	4	theme	cargoes	924:930	arg1	transport					885:893	the transport	881:893	the transport of multiple sperm or medical cargoes to the area of interest	881:954	Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
32096976	2	5	theme	thrust	293:298	arg1	force					300:304	the low thrust force	285:304	the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood	285:444	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	3	6	theme	sperm	472:476	arg1	micromotor					478:487	a hybrid sperm micromotor	463:487	a hybrid sperm micromotor that can actively swim against flowing blood (continuous and pulsatile) and perform the function of heparin cargo delivery	463:610	Here we present a hybrid sperm micromotor that can actively swim against flowing blood (continuous and pulsatile) and perform the function of heparin cargo delivery.
32096976	2	7	theme	micromotors	350:360	arg1	sufficient					376:385	sufficient	376:385	sufficient	376:385	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	2	7	theme	micromotors	350:360	arg1	micromotors					350:360	the reported synthetic micromotors	327:360	the reported synthetic micromotors	327:360	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	2	7	theme	micromotors	350:360	arg1	many					319:322	many	319:322	many	319:322	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	1	8	from	delivery	163:170	arg1	environments					194:205	complex biological environments	175:205	complex biological environments	175:205	Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo delivery in complex biological environments.
32096976	2	9	theme	low	289:291	arg1	force					300:304	the low thrust force	285:304	the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood	285:444	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	5	10	theme	medical	916:922	arg1	cargoes					924:930	multiple sperm or medical cargoes	898:930	cargoes	924:930	Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
32096976	1	11	theme	biological	183:192	arg1	environments					194:205	complex biological environments	175:205	complex biological environments	175:205	Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo delivery in complex biological environments.
32096976	2	12	from	feasibility	223:233	arg1	system					254:259	the circulatory system	238:259	the circulatory system	238:259	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	5	13	theme	multiple	898:905	arg1	sperm					907:911	multiple sperm or medical cargoes	898:930	sperm	907:911	Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
32096976	0	14	theme	Sperm	0:4	arg1	Micromotors					6:16	Sperm Micromotors	0:16	Sperm Micromotors for Cargo	0:26	Sperm Micromotors for Cargo Delivery through Flowing Blood.
32096976	5	15	theme	sperm	794:798	arg1	micromotors					800:810	single sperm micromotors	787:810	single sperm micromotors	787:810	Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
32096976	2	16	theme	blood	440:444	arg1	flow					408:411	the high flow	399:411	the high flow	399:411	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	2	16	theme	blood	440:444	arg1	composition					425:435	complex composition	417:435	complex composition of blood	417:444	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	1	17	theme	promising	90:98	arg1	candidates					100:109	promising candidates	90:109	promising candidates for untethered micromanipulation and targeted cargo delivery in complex biological environments	90:205	Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo delivery in complex biological environments.
32096976	1	17	theme	promising	90:98	arg1	Micromotors					60:70	Micromotors	60:70	Micromotors	60:70	Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo delivery in complex biological environments.
32096976	4	18	theme	sperm	643:647	arg1	flagellum					649:657	the sperm flagellum	639:657	the sperm flagellum	639:657	In this biohybrid system, the sperm flagellum provides a high propulsion force while the synthetic microstructure serves for magnetic guidance and cargo transport.
32096976	1	19	from	micromanipulation	126:142	arg1	environments					194:205	complex biological environments	175:205	complex biological environments	175:205	Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo delivery in complex biological environments.
32096976	4	20	theme	magnetic	738:745	arg1	guidance					747:754	magnetic guidance	738:754	magnetic guidance	738:754	In this biohybrid system, the sperm flagellum provides a high propulsion force while the synthetic microstructure serves for magnetic guidance and cargo transport.
32096976	2	21	theme	complex	417:423	arg1	composition					425:435	complex composition	417:435	complex composition of blood	417:444	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	5	22	theme	circulatory	1045:1055	arg1	system					1057:1062	the circulatory system	1041:1062	the circulatory system	1041:1062	Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
32096976	4	23	theme	high	670:673	arg1	force					686:690	a high propulsion force	668:690	a high propulsion force	668:690	In this biohybrid system, the sperm flagellum provides a high propulsion force while the synthetic microstructure serves for magnetic guidance and cargo transport.
32096976	3	24	dep	blood	528:532	arg1	pulsatile					550:558	pulsatile	550:558	pulsatile	550:558	Here we present a hybrid sperm micromotor that can actively swim against flowing blood (continuous and pulsatile) and perform the function of heparin cargo delivery.
32096976	3	24	dep	blood	528:532	arg1	continuous					535:544	continuous	535:544	continuous	535:544	Here we present a hybrid sperm micromotor that can actively swim against flowing blood (continuous and pulsatile) and perform the function of heparin cargo delivery.
32096976	5	25	theme	train-like	832:841	arg1	carrier					843:849	a train-like carrier	830:849	a train-like carrier	830:849	Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
32096976	5	26	theme	blood	1008:1012	arg1	clots					1014:1018	blood clots	1008:1018	blood clots	1008:1018	Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
32096976	2	27	theme	high	403:406	arg1	flow					408:411	the high flow	399:411	the high flow	399:411	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	5	28	theme	single	787:792	arg1	micromotors					800:810	single sperm micromotors	787:810	single sperm micromotors	787:810	Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
32096976	2	29	theme	circulatory	242:252	arg1	system					254:259	the circulatory system	238:259	the circulatory system	238:259	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	1	30	theme	untethered	115:124	arg1	micromanipulation					126:142	untethered micromanipulation	115:142	untethered micromanipulation	115:142	Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo delivery in complex biological environments.
32096976	0	31	theme	Flowing	45:51	arg1	Blood					53:57	Flowing Blood	45:57	Flowing Blood	45:57	Sperm Micromotors for Cargo Delivery through Flowing Blood.
32096976	5	32	theme	other	1023:1027	arg1	diseases					1029:1036	other diseases	1023:1036	other diseases	1023:1036	Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
32096976	2	33	theme	synthetic	340:348	arg1	sufficient					376:385	sufficient	376:385	sufficient	376:385	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	2	33	theme	synthetic	340:348	arg1	micromotors					350:360	the reported synthetic micromotors	327:360	the reported synthetic micromotors	327:360	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	5	34	theme	potential	968:976	arg1	agents					992:997	potential anticoagulant agents	968:997	potential anticoagulant agents	968:997	Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
32096976	3	35	theme	delivery	603:610	arg1	function					577:584	the function	573:584	the function of heparin cargo delivery	573:610	Here we present a hybrid sperm micromotor that can actively swim against flowing blood (continuous and pulsatile) and perform the function of heparin cargo delivery.
32096976	3	36	theme	hybrid	465:470	arg1	micromotor					478:487	a hybrid sperm micromotor	463:487	a hybrid sperm micromotor that can actively swim against flowing blood (continuous and pulsatile) and perform the function of heparin cargo delivery	463:610	Here we present a hybrid sperm micromotor that can actively swim against flowing blood (continuous and pulsatile) and perform the function of heparin cargo delivery.
32096976	4	37	theme	cargo	760:764	arg1	transport					766:774	cargo transport	760:774	cargo transport	760:774	In this biohybrid system, the sperm flagellum provides a high propulsion force while the synthetic microstructure serves for magnetic guidance and cargo transport.
32096976	5	38	theme	sperm	907:911	arg1	transport					885:893	the transport	881:893	the transport of multiple sperm or medical cargoes to the area of interest	881:954	Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
32096976	4	39	theme	synthetic	702:710	arg1	microstructure					712:725	the synthetic microstructure	698:725	the synthetic microstructure	698:725	In this biohybrid system, the sperm flagellum provides a high propulsion force while the synthetic microstructure serves for magnetic guidance and cargo transport.
32096976	1	40	theme	targeted	148:155	arg1	delivery					163:170	targeted cargo delivery	148:170	targeted cargo delivery	148:170	Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo delivery in complex biological environments.
32096976	2	41	theme	reported	331:338	arg1	sufficient					376:385	sufficient	376:385	sufficient	376:385	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	2	41	theme	reported	331:338	arg1	micromotors					350:360	the reported synthetic micromotors	327:360	the reported synthetic micromotors	327:360	However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood.
32096976	4	42	theme	biohybrid	621:629	arg1	system					631:636	this biohybrid system	616:636	this biohybrid system	616:636	In this biohybrid system, the sperm flagellum provides a high propulsion force while the synthetic microstructure serves for magnetic guidance and cargo transport.
32096976	3	43	theme	heparin	589:595	arg1	delivery					603:610	heparin cargo delivery	589:610	heparin cargo delivery	589:610	Here we present a hybrid sperm micromotor that can actively swim against flowing blood (continuous and pulsatile) and perform the function of heparin cargo delivery.
32096976	1	44	theme	cargo	157:161	arg1	delivery					163:170	targeted cargo delivery	148:170	targeted cargo delivery	148:170	Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo delivery in complex biological environments.
32096976	3	45	theme	cargo	597:601	arg1	delivery					603:610	heparin cargo delivery	589:610	heparin cargo delivery	589:610	Here we present a hybrid sperm micromotor that can actively swim against flowing blood (continuous and pulsatile) and perform the function of heparin cargo delivery.
31938903	2	0	theme	activity	356:363	arg1	absence					292:298	the absence	288:298	the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters	288:404	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	2	1	theme	osmotic	348:354	arg1	activity					356:363	osmotic activity	348:363	osmotic activity	348:363	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	3	2	theme	best	542:545	arg1	results					547:553	results	547:553	results	547:553	The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.
31938903	2	3	theme	effect	317:322	arg1	absence					292:298	the absence	288:298	the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters	288:404	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	2	4	theme	Experimental	146:157	arg1	samples					159:165	Experimental samples	146:165	Experimental samples of the gel based on different gelling agents	146:210	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	3	5	dep	results	547:553	arg1	the					538:540	the	538:540	the	538:540	The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.
31938903	2	6	theme	parameters	395:404	arg1	absence					292:298	the absence	288:298	the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters	288:404	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	3	7	theme	gelling	517:523	arg1	agent					525:529	a gelling agent	515:529	a gelling agent	515:529	The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.
31938903	2	8	theme	rheological	383:393	arg1	parameters					395:404	rheological parameters	383:404	rheological parameters	383:404	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	0	9	theme	Combined	4:11	arg1	Gel					17:19	New Combined Eye Gel	0:19	New Combined Eye Gel with Alpha-2-Beta Interferon.	0:49	New Combined Eye Gel with Alpha-2-Beta Interferon.
31938903	1	10	with	gel	98:100	arg1	alpha-2-beta					118:129	interferon alpha-2-beta	107:129	interferon alpha-2-beta	107:129	The results of the development of combined eye gel with interferon alpha-2-beta are presented.
31938903	1	11	theme	development	70:80	arg1	results					55:61	The results	51:61	The results of the development of combined eye gel with interferon alpha-2-beta	51:129	The results of the development of combined eye gel with interferon alpha-2-beta are presented.
31938903	0	12	theme	New	0:2	arg1	Gel					17:19	New Combined Eye Gel	0:19	New Combined Eye Gel with Alpha-2-Beta Interferon.	0:49	New Combined Eye Gel with Alpha-2-Beta Interferon.
31938903	2	13	theme	cytotoxic	307:315	arg1	effect					317:322	the cytotoxic effect	303:322	the cytotoxic effect	303:322	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	1	14	theme	combined	85:92	arg1	gel					98:100	combined eye gel	85:100	combined eye gel with interferon alpha-2-beta	85:129	The results of the development of combined eye gel with interferon alpha-2-beta are presented.
31938903	3	15	theme	Natrosol	468:475	arg1	cellulose					457:465	hydroxyethyl cellulose	444:465	hydroxyethyl cellulose	444:465	The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.
31938903	3	15	theme	Natrosol	468:475	arg1	250HHX					477:482	Natrosol 250HHX	468:482	Natrosol 250HHX	468:482	The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.
31938903	0	16	theme	Eye	13:15	arg1	Gel					17:19	New Combined Eye Gel	0:19	New Combined Eye Gel with Alpha-2-Beta Interferon.	0:49	New Combined Eye Gel with Alpha-2-Beta Interferon.
31938903	2	17	theme	gel	174:176	arg1	samples					159:165	Experimental samples	146:165	Experimental samples of the gel based on different gelling agents	146:210	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	1	18	theme	eye	94:96	arg1	gel					98:100	combined eye gel	85:100	combined eye gel with interferon alpha-2-beta	85:129	The results of the development of combined eye gel with interferon alpha-2-beta are presented.
31938903	3	19	theme	%	510:510	arg1	concentration					490:502	a concentration	488:502	a concentration of 1.5% as a gelling agent	488:529	The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.
31938903	0	20	theme	Alpha-2-Beta	26:37	arg1	Interferon					39:48	Alpha-2-Beta Interferon	26:48	Alpha-2-Beta Interferon	26:48	New Combined Eye Gel with Alpha-2-Beta Interferon.
31938903	3	21	theme	one-year	568:575	arg1	stability					577:585	the best one-year stability	559:585	the best one-year stability	559:585	The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.
31938903	0	22	with	Gel	17:19	arg1	Interferon					39:48	Alpha-2-Beta Interferon	26:48	Alpha-2-Beta Interferon	26:48	New Combined Eye Gel with Alpha-2-Beta Interferon.
31938903	1	23	theme	gel	98:100	arg1	development					70:80	the development	66:80	the development of combined eye gel with interferon alpha-2-beta	66:129	The results of the development of combined eye gel with interferon alpha-2-beta are presented.
31938903	3	24	with	composition	427:437	arg1	cellulose					457:465	hydroxyethyl cellulose	444:465	hydroxyethyl cellulose	444:465	The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.
31938903	3	24	with	composition	427:437	arg1	250HHX					477:482	Natrosol 250HHX	468:482	Natrosol 250HHX	468:482	The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.
31938903	2	25	theme	gelling	197:203	arg1	agents					205:210	different gelling agents	187:210	different gelling agents	187:210	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	3	26	theme	best	563:566	arg1	stability					577:585	the best one-year stability	559:585	the best one-year stability	559:585	The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.
31938903	2	27	theme	stability	337:345	arg1	absence					292:298	the absence	288:298	the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters	288:404	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	2	28	theme	different	187:195	arg1	agents					205:210	different gelling agents	187:210	different gelling agents	187:210	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	2	29	theme	technological	257:269	arg1	characteristics					271:285	their biotechnological and technological characteristics	230:285	their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters)	230:405	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	1	30	theme	interferon	107:116	arg1	alpha-2-beta					118:129	interferon alpha-2-beta	107:129	interferon alpha-2-beta	107:129	The results of the development of combined eye gel with interferon alpha-2-beta are presented.
31938903	2	31	theme	aggregation	325:335	arg1	stability					337:345	aggregation stability	325:345	aggregation stability	325:345	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	2	32	theme	biotechnological	236:251	arg1	characteristics					271:285	their biotechnological and technological characteristics	230:285	their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters)	230:405	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	3	33	from	composition	427:437	arg1	concentration					490:502	a concentration	488:502	a concentration of 1.5% as a gelling agent	488:529	The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.
31938903	2	34	theme	bioadhesion	366:376	arg1	absence					292:298	the absence	288:298	the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters	288:404	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
31938903	3	35	theme	hydroxyethyl	444:455	arg1	cellulose					457:465	hydroxyethyl cellulose	444:465	hydroxyethyl cellulose	444:465	The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.
31938903	3	35	theme	hydroxyethyl	444:455	arg1	250HHX					477:482	Natrosol 250HHX	468:482	Natrosol 250HHX	468:482	The composition with hydroxyethyl cellulose, Natrosol 250HHX, in a concentration of 1.5% as a gelling agent showed the best results and the best one-year stability.
31938903	2	36	dep	characteristics	271:285	arg1	absence					292:298	the absence	288:298	the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters	288:404	Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters) were evaluated.
32335314	5	0	theme	microbiota	706:715	arg1	composition					717:727	gut microbiota composition	702:727	gut microbiota composition	702:727	The results showed that D. magna treated with 9 and 27 mg l-1 DFO altered gut microbiota composition by increasing Limnohabitans and Lactobacillus, and significantly increased SOD activity and reduced lipid peroxidation.
32335314	7	1	theme	gut	1058:1060	arg1	microbiota					1062:1071	the gut microbiota	1054:1071	the gut microbiota of D. magna	1054:1083	Our results suggested that DFO changed the composition of the gut microbiota of D. magna by increasing the beneficial bacteria.
32335314	2	2	from	effects	291:297	arg1	expression					366:375	immune-related gene expression	346:375	immune-related gene expression	346:375	In this study, we aimed to investigate the effects of DFO on gut microbiota, oxidative stress and immune-related gene expression in Daphnia magna.
32335314	2	2	from	effects	291:297	arg1	microbiota					313:322	gut microbiota	309:322	gut microbiota	309:322	In this study, we aimed to investigate the effects of DFO on gut microbiota, oxidative stress and immune-related gene expression in Daphnia magna.
32335314	2	2	from	effects	291:297	arg1	stress					335:340	oxidative stress	325:340	oxidative stress	325:340	In this study, we aimed to investigate the effects of DFO on gut microbiota, oxidative stress and immune-related gene expression in Daphnia magna.
32335314	6	3	theme	D.	953:954	arg1	magna					956:960	D. magna	953:960	D. magna	953:960	Moreover, the expressions of Toll2, Toll3, Toll5, Toll7 and Pelle genes were significantly increased in D. magna treated with 9 and 27 mg l-1 DFO.
32335314	0	4	theme	oxidative	75:83	arg1	stress					85:90	oxidative stress	75:90	oxidative stress	75:90	Oligosaccharides derived from dragon fruit modulate gut microbiota, reduce oxidative stress and stimulate toll-pathway related gene expression in freshwater crustacean Daphnia magna.
32335314	4	5	theme	gut	475:477	arg1	communities					489:499	The gut bacterial communities	471:499	The gut bacterial communities	471:499	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	7	6	theme	microbiota	1062:1071	arg1	composition					1039:1049	the composition	1035:1049	the composition of the gut microbiota of D. magna	1035:1083	Our results suggested that DFO changed the composition of the gut microbiota of D. magna by increasing the beneficial bacteria.
32335314	2	7	from	microbiota	313:322	arg1	magna					388:392	Daphnia magna	380:392	Daphnia magna	380:392	In this study, we aimed to investigate the effects of DFO on gut microbiota, oxidative stress and immune-related gene expression in Daphnia magna.
32335314	6	8	dep	increased	940:948	arg1	treated					962:968	treated	962:968	treated with 9 and 27 mg l-1 DFO	962:993	Moreover, the expressions of Toll2, Toll3, Toll5, Toll7 and Pelle genes were significantly increased in D. magna treated with 9 and 27 mg l-1 DFO.
32335314	4	9	from	peroxidation	545:556	arg1	pathway					605:611	Toll signaling pathway	590:611	Toll signaling pathway	590:611	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	0	10	attach	derived	17:23	arg2	Oligosaccharides					0:15	Oligosaccharides	0:15	Oligosaccharides derived from dragon fruit	0:41	Oligosaccharides derived from dragon fruit modulate gut microbiota, reduce oxidative stress and stimulate toll-pathway related gene expression in freshwater crustacean Daphnia magna.
32335314	0	10	attach	derived	17:23	arg1	fruit					37:41	dragon fruit	30:41	dragon fruit	30:41	Oligosaccharides derived from dragon fruit modulate gut microbiota, reduce oxidative stress and stimulate toll-pathway related gene expression in freshwater crustacean Daphnia magna.
32335314	6	11	theme	genes	915:919	arg1	expressions					863:873	the expressions	859:873	the expressions of Toll2, Toll3, Toll5, Toll7 and Pelle genes	859:919	Moreover, the expressions of Toll2, Toll3, Toll5, Toll7 and Pelle genes were significantly increased in D. magna treated with 9 and 27 mg l-1 DFO.
32335314	6	12	theme	Toll5	892:896	arg1	genes					915:919	Toll2, Toll3, Toll5, Toll7 and Pelle genes	878:919	Toll2, Toll3, Toll5, Toll7 and Pelle genes	878:919	Moreover, the expressions of Toll2, Toll3, Toll5, Toll7 and Pelle genes were significantly increased in D. magna treated with 9 and 27 mg l-1 DFO.
32335314	3	13	theme	27 mg l-1	447:455	arg1	DFO					457:459	27 mg l-1 DFO	447:459	27 mg l-1 DFO	447:459	The 10-day-old D. magna were treated with 0, 9, and 27 mg l-1 DFO for 85 h.
32335314	0	14	theme	related	119:125	arg1	expression					132:141	toll-pathway related gene expression	106:141	toll-pathway related gene expression in freshwater crustacean Daphnia magna	106:180	Oligosaccharides derived from dragon fruit modulate gut microbiota, reduce oxidative stress and stimulate toll-pathway related gene expression in freshwater crustacean Daphnia magna.
32335314	5	15	theme	SOD	804:806	arg1	activity					808:815	SOD activity	804:815	SOD activity	804:815	The results showed that D. magna treated with 9 and 27 mg l-1 DFO altered gut microbiota composition by increasing Limnohabitans and Lactobacillus, and significantly increased SOD activity and reduced lipid peroxidation.
32335314	8	16	theme	immune-related	1280:1293	arg1	genes					1295:1299	immune-related genes	1280:1299	immune-related genes	1280:1299	DFO also had the ability to stimulate innate immunity in D. magna by increasing SOD activity, reducing lipid peroxidation, and increasing the expression of immune-related genes.
32335314	1	17	theme	Dragon	183:188	arg1	oligosaccharide					196:210	Dragon fruit oligosaccharide	183:210	Dragon fruit oligosaccharide (DFO)	183:216	Dragon fruit oligosaccharide (DFO) is an indigestible prebiotic.
32335314	1	17	theme	Dragon	183:188	arg1	prebiotic					237:245	an indigestible prebiotic	221:245	an indigestible prebiotic	221:245	Dragon fruit oligosaccharide (DFO) is an indigestible prebiotic.
32335314	1	17	theme	Dragon	183:188	arg1	DFO					213:215	DFO	213:215	DFO	213:215	Dragon fruit oligosaccharide (DFO) is an indigestible prebiotic.
32335314	4	18	theme	lipid	539:543	arg1	peroxidation					545:556	lipid peroxidation	539:556	lipid peroxidation	539:556	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	7	19	theme	magna	1079:1083	arg1	microbiota					1062:1071	the gut microbiota	1054:1071	the gut microbiota of D. magna	1054:1083	Our results suggested that DFO changed the composition of the gut microbiota of D. magna by increasing the beneficial bacteria.
32335314	1	20	theme	fruit	190:194	arg1	oligosaccharide					196:210	Dragon fruit oligosaccharide	183:210	Dragon fruit oligosaccharide (DFO)	183:216	Dragon fruit oligosaccharide (DFO) is an indigestible prebiotic.
32335314	1	20	theme	fruit	190:194	arg1	prebiotic					237:245	an indigestible prebiotic	221:245	an indigestible prebiotic	221:245	Dragon fruit oligosaccharide (DFO) is an indigestible prebiotic.
32335314	1	20	theme	fruit	190:194	arg1	DFO					213:215	DFO	213:215	DFO	213:215	Dragon fruit oligosaccharide (DFO) is an indigestible prebiotic.
32335314	7	21	theme	beneficial	1103:1112	arg1	bacteria					1114:1121	the beneficial bacteria	1099:1121	the beneficial bacteria	1099:1121	Our results suggested that DFO changed the composition of the gut microbiota of D. magna by increasing the beneficial bacteria.
32335314	2	22	from	stress	335:340	arg1	magna					388:392	Daphnia magna	380:392	Daphnia magna	380:392	In this study, we aimed to investigate the effects of DFO on gut microbiota, oxidative stress and immune-related gene expression in Daphnia magna.
32335314	8	23	theme	D.	1181:1182	arg1	magna					1184:1188	D. magna	1181:1188	D. magna	1181:1188	DFO also had the ability to stimulate innate immunity in D. magna by increasing SOD activity, reducing lipid peroxidation, and increasing the expression of immune-related genes.
32335314	6	24	theme	Toll2	878:882	arg1	genes					915:919	Toll2, Toll3, Toll5, Toll7 and Pelle genes	878:919	Toll2, Toll3, Toll5, Toll7 and Pelle genes	878:919	Moreover, the expressions of Toll2, Toll3, Toll5, Toll7 and Pelle genes were significantly increased in D. magna treated with 9 and 27 mg l-1 DFO.
32335314	5	25	theme	reduced	821:827	arg1	peroxidation					835:846	reduced lipid peroxidation	821:846	reduced lipid peroxidation	821:846	The results showed that D. magna treated with 9 and 27 mg l-1 DFO altered gut microbiota composition by increasing Limnohabitans and Lactobacillus, and significantly increased SOD activity and reduced lipid peroxidation.
32335314	2	26	theme	DFO	302:304	arg1	effects					291:297	the effects	287:297	the effects of DFO on gut microbiota, oxidative stress and immune-related gene expression in Daphnia magna	287:392	In this study, we aimed to investigate the effects of DFO on gut microbiota, oxidative stress and immune-related gene expression in Daphnia magna.
32335314	0	27	theme	dragon	30:35	arg1	fruit					37:41	dragon fruit	30:41	dragon fruit	30:41	Oligosaccharides derived from dragon fruit modulate gut microbiota, reduce oxidative stress and stimulate toll-pathway related gene expression in freshwater crustacean Daphnia magna.
32335314	4	28	theme	dismutase	513:521	arg1	activity					529:536	superoxide dismutase (SOD) activity	502:536	superoxide dismutase (SOD) activity	502:536	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	5	29	theme	D.	652:653	arg1	magna					655:659	D. magna	652:659	D. magna treated with 9 and 27 mg l-1 DFO	652:692	The results showed that D. magna treated with 9 and 27 mg l-1 DFO altered gut microbiota composition by increasing Limnohabitans and Lactobacillus, and significantly increased SOD activity and reduced lipid peroxidation.
32335314	8	30	theme	genes	1295:1299	arg1	expression					1266:1275	the expression	1262:1275	the expression of immune-related genes	1262:1299	DFO also had the ability to stimulate innate immunity in D. magna by increasing SOD activity, reducing lipid peroxidation, and increasing the expression of immune-related genes.
32335314	6	31	theme	Pelle	909:913	arg1	genes					915:919	Toll2, Toll3, Toll5, Toll7 and Pelle genes	878:919	Toll2, Toll3, Toll5, Toll7 and Pelle genes	878:919	Moreover, the expressions of Toll2, Toll3, Toll5, Toll7 and Pelle genes were significantly increased in D. magna treated with 9 and 27 mg l-1 DFO.
32335314	0	32	theme	gene	127:130	arg1	expression					132:141	toll-pathway related gene expression	106:141	toll-pathway related gene expression in freshwater crustacean Daphnia magna	106:180	Oligosaccharides derived from dragon fruit modulate gut microbiota, reduce oxidative stress and stimulate toll-pathway related gene expression in freshwater crustacean Daphnia magna.
32335314	4	33	theme	genes	581:585	arg1	activity					529:536	superoxide dismutase (SOD) activity	502:536	superoxide dismutase (SOD) activity	502:536	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	4	33	theme	genes	581:585	arg1	peroxidation					545:556	lipid peroxidation	539:556	lipid peroxidation	539:556	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	4	33	theme	genes	581:585	arg1	expressions					566:576	the expressions	562:576	the expressions of genes	562:585	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	4	33	theme	genes	581:585	arg1	communities					489:499	The gut bacterial communities	471:499	The gut bacterial communities	471:499	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	3	34	theme	10-day-old	399:408	arg1	magna					413:417	The 10-day-old D. magna	395:417	The 10-day-old D. magna	395:417	The 10-day-old D. magna were treated with 0, 9, and 27 mg l-1 DFO for 85 h.
32335314	0	35	theme	freshwater	146:155	arg1	magna					176:180	freshwater crustacean Daphnia magna	146:180	freshwater crustacean Daphnia magna	146:180	Oligosaccharides derived from dragon fruit modulate gut microbiota, reduce oxidative stress and stimulate toll-pathway related gene expression in freshwater crustacean Daphnia magna.
32335314	8	36	theme	SOD	1204:1206	arg1	activity					1208:1215	SOD activity	1204:1215	SOD activity	1204:1215	DFO also had the ability to stimulate innate immunity in D. magna by increasing SOD activity, reducing lipid peroxidation, and increasing the expression of immune-related genes.
32335314	4	37	theme	signaling	595:603	arg1	pathway					605:611	Toll signaling pathway	590:611	Toll signaling pathway	590:611	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	3	38	theme	D.	410:411	arg1	magna					413:417	The 10-day-old D. magna	395:417	The 10-day-old D. magna	395:417	The 10-day-old D. magna were treated with 0, 9, and 27 mg l-1 DFO for 85 h.
32335314	5	39	theme	lipid	829:833	arg1	peroxidation					835:846	reduced lipid peroxidation	821:846	reduced lipid peroxidation	821:846	The results showed that D. magna treated with 9 and 27 mg l-1 DFO altered gut microbiota composition by increasing Limnohabitans and Lactobacillus, and significantly increased SOD activity and reduced lipid peroxidation.
32335314	4	40	theme	Toll	590:593	arg1	pathway					605:611	Toll signaling pathway	590:611	Toll signaling pathway	590:611	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	4	41	from	communities	489:499	arg1	pathway					605:611	Toll signaling pathway	590:611	Toll signaling pathway	590:611	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	4	42	theme	bacterial	479:487	arg1	communities					489:499	The gut bacterial communities	471:499	The gut bacterial communities	471:499	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	0	43	theme	Daphnia	168:174	arg1	magna					176:180	freshwater crustacean Daphnia magna	146:180	freshwater crustacean Daphnia magna	146:180	Oligosaccharides derived from dragon fruit modulate gut microbiota, reduce oxidative stress and stimulate toll-pathway related gene expression in freshwater crustacean Daphnia magna.
32335314	5	44	theme	gut	702:704	arg1	composition					717:727	gut microbiota composition	702:727	gut microbiota composition	702:727	The results showed that D. magna treated with 9 and 27 mg l-1 DFO altered gut microbiota composition by increasing Limnohabitans and Lactobacillus, and significantly increased SOD activity and reduced lipid peroxidation.
32335314	2	45	from	expression	366:375	arg1	magna					388:392	Daphnia magna	380:392	Daphnia magna	380:392	In this study, we aimed to investigate the effects of DFO on gut microbiota, oxidative stress and immune-related gene expression in Daphnia magna.
32335314	2	46	theme	oxidative	325:333	arg1	stress					335:340	oxidative stress	325:340	oxidative stress	325:340	In this study, we aimed to investigate the effects of DFO on gut microbiota, oxidative stress and immune-related gene expression in Daphnia magna.
32335314	0	47	theme	gut	52:54	arg1	microbiota					56:65	gut microbiota	52:65	gut microbiota	52:65	Oligosaccharides derived from dragon fruit modulate gut microbiota, reduce oxidative stress and stimulate toll-pathway related gene expression in freshwater crustacean Daphnia magna.
32335314	4	48	theme	superoxide	502:511	arg1	SOD					524:526	SOD	524:526	SOD	524:526	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	4	48	theme	superoxide	502:511	arg1	dismutase					513:521	superoxide dismutase	502:521	superoxide dismutase (SOD) activity	502:536	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	0	49	theme	crustacean	157:166	arg1	magna					176:180	freshwater crustacean Daphnia magna	146:180	freshwater crustacean Daphnia magna	146:180	Oligosaccharides derived from dragon fruit modulate gut microbiota, reduce oxidative stress and stimulate toll-pathway related gene expression in freshwater crustacean Daphnia magna.
32335314	6	50	theme	Toll7	899:903	arg1	genes					915:919	Toll2, Toll3, Toll5, Toll7 and Pelle genes	878:919	Toll2, Toll3, Toll5, Toll7 and Pelle genes	878:919	Moreover, the expressions of Toll2, Toll3, Toll5, Toll7 and Pelle genes were significantly increased in D. magna treated with 9 and 27 mg l-1 DFO.
32335314	7	51	theme	D.	1076:1077	arg1	magna					1079:1083	D. magna	1076:1083	D. magna	1076:1083	Our results suggested that DFO changed the composition of the gut microbiota of D. magna by increasing the beneficial bacteria.
32335314	8	52	theme	lipid	1227:1231	arg1	peroxidation					1233:1244	lipid peroxidation	1227:1244	lipid peroxidation	1227:1244	DFO also had the ability to stimulate innate immunity in D. magna by increasing SOD activity, reducing lipid peroxidation, and increasing the expression of immune-related genes.
32335314	1	53	theme	indigestible	224:235	arg1	oligosaccharide					196:210	Dragon fruit oligosaccharide	183:210	Dragon fruit oligosaccharide (DFO)	183:216	Dragon fruit oligosaccharide (DFO) is an indigestible prebiotic.
32335314	1	53	theme	indigestible	224:235	arg1	prebiotic					237:245	an indigestible prebiotic	221:245	an indigestible prebiotic	221:245	Dragon fruit oligosaccharide (DFO) is an indigestible prebiotic.
32335314	8	54	theme	innate	1162:1167	arg1	immunity					1169:1176	innate immunity	1162:1176	innate immunity	1162:1176	DFO also had the ability to stimulate innate immunity in D. magna by increasing SOD activity, reducing lipid peroxidation, and increasing the expression of immune-related genes.
32335314	8	55	contain	had	1133:1135	arg2	ability					1141:1147	the ability to stimulate innate immunity in D. magna by increasing SOD activity, reducing lipid peroxidation, and increasing the expression of immune-related genes	1137:1299	the ability to stimulate innate immunity in D. magna by increasing SOD activity, reducing lipid peroxidation, and increasing the expression of immune-related genes	1137:1299	DFO also had the ability to stimulate innate immunity in D. magna by increasing SOD activity, reducing lipid peroxidation, and increasing the expression of immune-related genes.
32335314	8	55	contain	had	1133:1135	arg1	DFO					1124:1126	DFO	1124:1126	DFO	1124:1126	DFO also had the ability to stimulate innate immunity in D. magna by increasing SOD activity, reducing lipid peroxidation, and increasing the expression of immune-related genes.
32335314	2	56	theme	gut	309:311	arg1	microbiota					313:322	gut microbiota	309:322	gut microbiota	309:322	In this study, we aimed to investigate the effects of DFO on gut microbiota, oxidative stress and immune-related gene expression in Daphnia magna.
32335314	4	57	from	activity	529:536	arg1	pathway					605:611	Toll signaling pathway	590:611	Toll signaling pathway	590:611	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	2	58	theme	gene	361:364	arg1	expression					366:375	immune-related gene expression	346:375	immune-related gene expression	346:375	In this study, we aimed to investigate the effects of DFO on gut microbiota, oxidative stress and immune-related gene expression in Daphnia magna.
32335314	2	59	theme	Daphnia	380:386	arg1	magna					388:392	Daphnia magna	380:392	Daphnia magna	380:392	In this study, we aimed to investigate the effects of DFO on gut microbiota, oxidative stress and immune-related gene expression in Daphnia magna.
32335314	0	60	from	expression	132:141	arg1	magna					176:180	freshwater crustacean Daphnia magna	146:180	freshwater crustacean Daphnia magna	146:180	Oligosaccharides derived from dragon fruit modulate gut microbiota, reduce oxidative stress and stimulate toll-pathway related gene expression in freshwater crustacean Daphnia magna.
32335314	4	61	from	expressions	566:576	arg1	pathway					605:611	Toll signaling pathway	590:611	Toll signaling pathway	590:611	The gut bacterial communities, superoxide dismutase (SOD) activity, lipid peroxidation and the expressions of genes in Toll signaling pathway were observed.
32335314	6	62	theme	Toll3	885:889	arg1	genes					915:919	Toll2, Toll3, Toll5, Toll7 and Pelle genes	878:919	Toll2, Toll3, Toll5, Toll7 and Pelle genes	878:919	Moreover, the expressions of Toll2, Toll3, Toll5, Toll7 and Pelle genes were significantly increased in D. magna treated with 9 and 27 mg l-1 DFO.
32335314	2	63	theme	immune-related	346:359	arg1	expression					366:375	immune-related gene expression	346:375	immune-related gene expression	346:375	In this study, we aimed to investigate the effects of DFO on gut microbiota, oxidative stress and immune-related gene expression in Daphnia magna.
32768986	2	0	theme	water	455:459	arg1	suspensions					461:471	water suspensions	455:471	water suspensions of zein and zein/rosin nanoparticles	455:508	Nanoparticles suspensions were then dialyzed against water in order to remove ethanol and other impurities, and water suspensions of zein and zein/rosin nanoparticles were obtained.
32768986	5	1	theme	SEM	730:732	arg1	analysis					734:741	SEM analysis	730:741	SEM analysis	730:741	SEM analysis proved both Z and Z/R nanoparticles to be spherical and in size around 200 nm.
32768986	1	2	theme	zein	148:151	arg1	nanoparticles					178:190	zein (Z) and zein/rosin (Z/R) nanoparticles	148:190	zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions	148:340	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	2	3	dep	zein	476:479	arg1	nanoparticles					496:508	nanoparticles	496:508	nanoparticles	496:508	Nanoparticles suspensions were then dialyzed against water in order to remove ethanol and other impurities, and water suspensions of zein and zein/rosin nanoparticles were obtained.
32768986	1	4	theme	biopolymers	299:309	arg1	precipitation					282:294	antisolvent precipitation	270:294	antisolvent precipitation of biopolymers from aqueous ethanol solutions	270:340	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	10	5	theme	Z/R	1325:1327	arg1	NPs					1329:1331	GA and Z or Z/R NPs	1313:1331	NPs	1329:1331	Results showed that reaction between GA and Z or Z/R NPs is exothermic at each pH tested, except for Z NPs at pH = 3, where it was endothermic.
32768986	6	6	theme	GA	848:849	arg1	addition					836:843	addition	836:843	addition of GA	836:849	The effect of addition of GA on particle size was determined using dynamic light scattering method.
32768986	11	7	theme	saturated	1505:1513	arg1	molecules					1523:1531	saturated with GA molecules	1505:1531	saturated with GA molecules	1505:1531	At presented pHs, Z/R NPs were less charged compared to Z NPs, and their surface get saturated with GA molecules more rapidly.
32768986	2	8	theme	zein/rosin	485:494	arg1	suspensions					461:471	water suspensions	455:471	water suspensions of zein and zein/rosin nanoparticles	455:508	Nanoparticles suspensions were then dialyzed against water in order to remove ethanol and other impurities, and water suspensions of zein and zein/rosin nanoparticles were obtained.
32768986	1	9	theme	aqueous	316:322	arg1	solutions					332:340	aqueous ethanol solutions	316:340	aqueous ethanol solutions	316:340	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	9	10	theme	Z/R	1250:1252	arg1	nanoparticles					1254:1266	Z or Z/R nanoparticles	1245:1266	Z or Z/R nanoparticles	1245:1266	Isothermal titration calorimetry was used to measure enthalpy changes in reaction between Z or Z/R nanoparticles and GA.
32768986	10	11	from	pH = 3	1386:1391	arg1	NPs					1379:1381	Z NPs	1377:1381	Z NPs	1377:1381	Results showed that reaction between GA and Z or Z/R NPs is exothermic at each pH tested, except for Z NPs at pH = 3, where it was endothermic.
32768986	1	12	from	precipitation	282:294	arg1	solutions					332:340	aqueous ethanol solutions	316:340	aqueous ethanol solutions	316:340	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	1	13	theme	ethanol	324:330	arg1	solutions					332:340	aqueous ethanol solutions	316:340	aqueous ethanol solutions	316:340	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	6	14	theme	particle	854:861	arg1	size					863:866	particle size	854:866	particle size	854:866	The effect of addition of GA on particle size was determined using dynamic light scattering method.
32768986	8	15	theme	few	1138:1140	arg1	micrometres					1142:1152	few micrometres	1138:1152	few micrometres	1138:1152	However, at pH = 3 it causes aggregation process, and diameter of particles increases up to few micrometres.
32768986	2	16	theme	zein	476:479	arg1	suspensions					461:471	water suspensions	455:471	water suspensions of zein and zein/rosin nanoparticles	455:508	Nanoparticles suspensions were then dialyzed against water in order to remove ethanol and other impurities, and water suspensions of zein and zein/rosin nanoparticles were obtained.
32768986	8	17	theme	particles	1112:1120	arg1	diameter					1100:1107	diameter	1100:1107	diameter of particles	1100:1120	However, at pH = 3 it causes aggregation process, and diameter of particles increases up to few micrometres.
32768986	11	18	theme	presented	1423:1431	arg1	pHs					1433:1435	presented pHs	1423:1435	presented pHs	1423:1435	At presented pHs, Z/R NPs were less charged compared to Z NPs, and their surface get saturated with GA molecules more rapidly.
32768986	8	19	theme	aggregation	1075:1085	arg1	process					1087:1093	aggregation process	1075:1093	aggregation process	1075:1093	However, at pH = 3 it causes aggregation process, and diameter of particles increases up to few micrometres.
32768986	1	20	from	solutions	332:340	arg1	biopolymers					299:309	biopolymers	299:309	biopolymers from aqueous ethanol solutions	299:340	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	1	20	from	solutions	332:340	arg1	precipitation					282:294	antisolvent precipitation	270:294	antisolvent precipitation of biopolymers from aqueous ethanol solutions	270:340	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	9	21	theme	Z	1245:1245	arg1	nanoparticles					1254:1266	Z or Z/R nanoparticles	1245:1266	Z or Z/R nanoparticles	1245:1266	Isothermal titration calorimetry was used to measure enthalpy changes in reaction between Z or Z/R nanoparticles and GA.
32768986	6	22	theme	addition	836:843	arg1	effect					826:831	The effect	822:831	The effect of addition of GA on particle size	822:866	The effect of addition of GA on particle size was determined using dynamic light scattering method.
32768986	7	23	dep	250	1032:1034	arg1	to					1029:1030	to	1029:1030	to	1029:1030	It was found that addition of GA increases size of nanoparticles at pH = 4 and pH = 5.5, from 150 - 220 nm to 250 - 320 nm.
32768986	1	24	theme	different	217:225	arg1	Nanoparticles					231:243	different pH. Nanoparticles	217:243	different pH. Nanoparticles	217:243	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	9	25	used	used	1192:1195	arg2	calorimetry					1176:1186	Isothermal titration calorimetry	1155:1186	Isothermal titration calorimetry	1155:1186	Isothermal titration calorimetry was used to measure enthalpy changes in reaction between Z or Z/R nanoparticles and GA.
32768986	11	26	theme	Z	1476:1476	arg1	NPs					1478:1480	Z NPs	1476:1480	Z NPs	1476:1480	At presented pHs, Z/R NPs were less charged compared to Z NPs, and their surface get saturated with GA molecules more rapidly.
32768986	1	27	theme	zein/rosin	161:170	arg1	nanoparticles					178:190	zein (Z) and zein/rosin (Z/R) nanoparticles	148:190	zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions	148:340	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	9	28	from	changes	1217:1223	arg1	reaction					1228:1235	reaction	1228:1235	reaction between Z or Z/R nanoparticles and GA	1228:1273	Isothermal titration calorimetry was used to measure enthalpy changes in reaction between Z or Z/R nanoparticles and GA.
32768986	1	29	theme	pH.	227:229	arg1	Nanoparticles					231:243	different pH. Nanoparticles	217:243	different pH. Nanoparticles	217:243	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	10	30	theme	Z	1377:1377	arg1	NPs					1379:1381	Z NPs	1377:1381	Z NPs	1377:1381	Results showed that reaction between GA and Z or Z/R NPs is exothermic at each pH tested, except for Z NPs at pH = 3, where it was endothermic.
32768986	12	31	theme	enthalpy	1568:1575	arg1	change					1577:1582	greater enthalpy change	1560:1582	greater enthalpy change in reaction with GA	1560:1602	Z NPs showed greater enthalpy change in reaction with GA, compared to Z/R NPs.
32768986	5	32	theme	Z	755:755	arg1	nanoparticles					765:777	both Z and Z/R nanoparticles	750:777	both Z and Z/R nanoparticles	750:777	SEM analysis proved both Z and Z/R nanoparticles to be spherical and in size around 200 nm.
32768986	12	33	from	change	1577:1582	arg1	reaction					1587:1594	reaction	1587:1594	reaction with GA	1587:1602	Z NPs showed greater enthalpy change in reaction with GA, compared to Z/R NPs.
32768986	0	34	theme	zein	16:19	arg1	nanoparticles					36:48	zein and zein/rosin nanoparticles	16:48	zein and zein/rosin nanoparticles	16:48	Interactions of zein and zein/rosin nanoparticles with natural polyanion gum arabic.
32768986	6	35	theme	scattering	903:912	arg1	method					914:919	dynamic light scattering method	889:919	dynamic light scattering method	889:919	The effect of addition of GA on particle size was determined using dynamic light scattering method.
32768986	1	36	with	nanoparticles	178:190	arg1	arabic					201:206	gum arabic	197:206	gum arabic (GA)	197:211	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	1	36	with	nanoparticles	178:190	arg1	GA					209:210	GA	209:210	GA	209:210	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	1	37	dep	arabic	201:206	arg1	prepared					258:265	prepared	258:265	were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions	245:340	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	10	38	from	pH	1355:1356	arg1	exothermic					1336:1345	exothermic	1336:1345	exothermic	1336:1345	Results showed that reaction between GA and Z or Z/R NPs is exothermic at each pH tested, except for Z NPs at pH = 3, where it was endothermic.
32768986	2	39	theme	other	433:437	arg1	impurities					439:448	other impurities	433:448	other impurities	433:448	Nanoparticles suspensions were then dialyzed against water in order to remove ethanol and other impurities, and water suspensions of zein and zein/rosin nanoparticles were obtained.
32768986	4	40	theme	Zeta	610:613	arg1	potential					615:623	Zeta potential	610:623	Zeta potential of nanoparticles	610:640	Zeta potential of nanoparticles was positive without GA and changed to negative after addition of GA, at all pH tested.
32768986	0	41	theme	nanoparticles	36:48	arg1	Interactions					0:11	Interactions	0:11	Interactions of zein and zein/rosin nanoparticles with natural polyanion gum	0:75	Interactions of zein and zein/rosin nanoparticles with natural polyanion gum arabic.
32768986	6	42	theme	light	897:901	arg1	scattering					903:912	dynamic light scattering	889:912	dynamic light scattering method	889:919	The effect of addition of GA on particle size was determined using dynamic light scattering method.
32768986	2	43	theme	Nanoparticles	343:355	arg1	suspensions					357:367	Nanoparticles suspensions	343:367	Nanoparticles suspensions	343:367	Nanoparticles suspensions were then dialyzed against water in order to remove ethanol and other impurities, and water suspensions of zein and zein/rosin nanoparticles were obtained.
32768986	4	44	theme	nanoparticles	628:640	arg1	potential					615:623	Zeta potential	610:623	Zeta potential of nanoparticles	610:640	Zeta potential of nanoparticles was positive without GA and changed to negative after addition of GA, at all pH tested.
32768986	0	45	theme	zein/rosin	25:34	arg1	nanoparticles					36:48	zein and zein/rosin nanoparticles	16:48	zein and zein/rosin nanoparticles	16:48	Interactions of zein and zein/rosin nanoparticles with natural polyanion gum arabic.
32768986	6	46	theme	dynamic	889:895	arg1	scattering					903:912	dynamic light scattering	889:912	dynamic light scattering method	889:919	The effect of addition of GA on particle size was determined using dynamic light scattering method.
32768986	7	47	theme	GA	952:953	arg1	addition					940:947	addition	940:947	addition of GA	940:953	It was found that addition of GA increases size of nanoparticles at pH = 4 and pH = 5.5, from 150 - 220 nm to 250 - 320 nm.
32768986	1	48	theme	nanoparticles	178:190	arg1	interactions					132:143	interactions	132:143	interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions	132:340	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	0	49	theme	natural	55:61	arg1	gum					73:75	natural polyanion gum	55:75	natural polyanion gum	55:75	Interactions of zein and zein/rosin nanoparticles with natural polyanion gum arabic.
32768986	11	50	dep	surface	1493:1499	arg1	get					1501:1503	get	1501:1503	get saturated with GA molecules more rapidly	1501:1544	At presented pHs, Z/R NPs were less charged compared to Z NPs, and their surface get saturated with GA molecules more rapidly.
32768986	7	51	theme	nanoparticles	973:985	arg1	size					965:968	size	965:968	size of nanoparticles	965:985	It was found that addition of GA increases size of nanoparticles at pH = 4 and pH = 5.5, from 150 - 220 nm to 250 - 320 nm.
32768986	1	52	theme	study	107:111	arg1	objective					89:97	The objective	85:97	The objective of this study	85:111	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	9	53	theme	enthalpy	1208:1215	arg1	changes					1217:1223	enthalpy changes	1208:1223	enthalpy changes in reaction between Z or Z/R nanoparticles and GA	1208:1273	Isothermal titration calorimetry was used to measure enthalpy changes in reaction between Z or Z/R nanoparticles and GA.
32768986	9	54	theme	Isothermal	1155:1164	arg1	calorimetry					1176:1186	Isothermal titration calorimetry	1155:1186	Isothermal titration calorimetry	1155:1186	Isothermal titration calorimetry was used to measure enthalpy changes in reaction between Z or Z/R nanoparticles and GA.
32768986	3	55	theme	nanoparticles	558:570	arg1	composition					543:553	composition	543:553	composition of nanoparticles	543:570	It was shown that composition of nanoparticles affects their surface charge density.
32768986	1	56	theme	antisolvent	270:280	arg1	precipitation					282:294	antisolvent precipitation	270:294	antisolvent precipitation of biopolymers from aqueous ethanol solutions	270:340	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	9	57	theme	titration	1166:1174	arg1	calorimetry					1176:1186	Isothermal titration calorimetry	1155:1186	Isothermal titration calorimetry	1155:1186	Isothermal titration calorimetry was used to measure enthalpy changes in reaction between Z or Z/R nanoparticles and GA.
32768986	0	58	with	Interactions	0:11	arg1	gum					73:75	natural polyanion gum	55:75	natural polyanion gum	55:75	Interactions of zein and zein/rosin nanoparticles with natural polyanion gum arabic.
32768986	4	59	theme	GA	708:709	arg1	addition					696:703	addition	696:703	addition of GA	696:709	Zeta potential of nanoparticles was positive without GA and changed to negative after addition of GA, at all pH tested.
32768986	11	60	theme	Z/R	1438:1440	arg1	NPs					1442:1444	Z/R NPs	1438:1444	Z/R NPs	1438:1444	At presented pHs, Z/R NPs were less charged compared to Z NPs, and their surface get saturated with GA molecules more rapidly.
32768986	12	61	theme	greater	1560:1566	arg1	change					1577:1582	greater enthalpy change	1560:1582	greater enthalpy change in reaction with GA	1560:1602	Z NPs showed greater enthalpy change in reaction with GA, compared to Z/R NPs.
32768986	11	62	from	pHs	1433:1435	arg1	charged					1456:1462	charged	1456:1462	charged	1456:1462	At presented pHs, Z/R NPs were less charged compared to Z NPs, and their surface get saturated with GA molecules more rapidly.
32768986	1	63	theme	gum	197:199	arg1	arabic					201:206	gum arabic	197:206	gum arabic (GA)	197:211	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	1	63	theme	gum	197:199	arg1	GA					209:210	GA	209:210	GA	209:210	The objective of this study was to investigate interactions of zein (Z) and zein/rosin (Z/R) nanoparticles with gum arabic (GA), at different pH. Nanoparticles were firstly prepared by antisolvent precipitation of biopolymers from aqueous ethanol solutions.
32768986	12	64	theme	Z	1547:1547	arg1	NPs					1549:1551	Z NPs	1547:1551	Z NPs	1547:1551	Z NPs showed greater enthalpy change in reaction with GA, compared to Z/R NPs.
32768986	3	65	theme	surface	586:592	arg1	density					601:607	their surface charge density	580:607	their surface charge density	580:607	It was shown that composition of nanoparticles affects their surface charge density.
32768986	12	66	with	reaction	1587:1594	arg1	GA					1601:1602	GA	1601:1602	GA	1601:1602	Z NPs showed greater enthalpy change in reaction with GA, compared to Z/R NPs.
32768986	11	67	with	saturated	1505:1513	arg1	GA					1520:1521	GA	1520:1521	GA	1520:1521	At presented pHs, Z/R NPs were less charged compared to Z NPs, and their surface get saturated with GA molecules more rapidly.
32768986	0	68	theme	polyanion	63:71	arg1	gum					73:75	natural polyanion gum	55:75	natural polyanion gum	55:75	Interactions of zein and zein/rosin nanoparticles with natural polyanion gum arabic.
32768986	3	69	theme	charge	594:599	arg1	density					601:607	their surface charge density	580:607	their surface charge density	580:607	It was shown that composition of nanoparticles affects their surface charge density.
32768986	12	70	theme	Z/R	1617:1619	arg1	NPs					1621:1623	Z/R NPs	1617:1623	Z/R NPs	1617:1623	Z NPs showed greater enthalpy change in reaction with GA, compared to Z/R NPs.
32768986	5	71	theme	Z/R	761:763	arg1	nanoparticles					765:777	both Z and Z/R nanoparticles	750:777	both Z and Z/R nanoparticles	750:777	SEM analysis proved both Z and Z/R nanoparticles to be spherical and in size around 200 nm.
32768986	6	72	from	effect	826:831	arg1	size					863:866	particle size	854:866	particle size	854:866	The effect of addition of GA on particle size was determined using dynamic light scattering method.
32071457	6	0	theme	kit-8	881:885	arg1	method					895:900	the cell counting kit-8 (CCK-8) method	863:900	the cell counting kit-8 (CCK-8) method	863:900	The proliferation of hDPCs in hydrogels was detected using the cell counting kit-8 (CCK-8) method and CalceinAM/PI Live/Dead assay.
32071457	7	1	theme	matrix	1070:1075	arg1	DMP-1					1088:1092	DMP-1	1088:1092	DMP-1	1088:1092	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	7	1	theme	matrix	1070:1075	arg1	protein-1					1077:1085	dentin matrix protein-1	1063:1085	dentin matrix protein-1 (DMP-1)	1063:1093	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	13	2	theme	single-network	1837:1850	arg1	hydrogel					1852:1859	single-network hydrogel	1837:1859	single-network hydrogel	1837:1859	The compressive strength of dual-network hydrogel was significantly enhanced compared with single-network hydrogel.
32071457	17	3	theme	higher	2707:2712	arg1	rate					2728:2731	a higher proliferation rate	2705:2731	a higher proliferation rate	2705:2731	GC31 group had a lower mechanical properties, in which hDPCs exhibited a higher proliferation rate.
32071457	15	4	theme	mineralized	2350:2360	arg1	nodules					2362:2368	mass-shaped mineralized nodules	2338:2368	mass-shaped mineralized nodules	2338:2368	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	6	5	theme	cell	867:870	arg1	method					895:900	the cell counting kit-8 (CCK-8) method	863:900	the cell counting kit-8 (CCK-8) method	863:900	The proliferation of hDPCs in hydrogels was detected using the cell counting kit-8 (CCK-8) method and CalceinAM/PI Live/Dead assay.
32071457	15	6	dep	groups	2064:2069	arg1	DN6262					2080:2085	DN6262	2080:2085	DN6262	2080:2085	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	11	7	theme	significant	1559:1569	arg1	difference					1571:1580	no significant difference	1556:1580	no significant difference between DN3131 and DN6262 (P>0.05)	1556:1615	There was no significant difference between DN3131 and DN6262 (P>0.05).
32071457	12	8	theme	GC31	1662:1665	arg1	group					1667:1671	GC31 group	1662:1671	GC31 group	1662:1671	The compressive resistance failure point of GC31 group was 1.10 kPa, while it was 7.33 kPa and 43.30 kPa for DN3131 and DN6262.
32071457	15	9	theme	calcium	2422:2428	arg1	staining					2441:2448	only light brown calcium deposition staining	2405:2448	only light brown calcium deposition staining	2405:2448	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	15	10	theme	ALP	2031:2033	arg1	levels					2005:2010	The expression levels	1990:2010	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262)	1990:2086	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	15	10	theme	ALP	2031:2033	arg1	higher					2107:2112	higher	2107:2112	higher	2107:2112	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	7	11	theme	sialophosphoprotein	1032:1050	arg1	expression					983:992	the expression	979:992	the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1)	979:1093	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	15	12	theme	light	2410:2414	arg1	staining					2441:2448	only light brown calcium deposition staining	2405:2448	only light brown calcium deposition staining	2405:2448	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	1	13	theme	single/dual-network	176:194	arg1	hydrogels					196:204	glycol-chitosan (GC)-based single/dual-network hydrogels	149:204	glycol-chitosan (GC)-based single/dual-network hydrogels	149:204	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	12	14	theme	resistance	1634:1643	arg1	kPa					1682:1684	1.10 kPa	1677:1684	1.10 kPa	1677:1684	The compressive resistance failure point of GC31 group was 1.10 kPa, while it was 7.33 kPa and 43.30 kPa for DN3131 and DN6262.
32071457	12	14	theme	resistance	1634:1643	arg1	point					1653:1657	The compressive resistance failure point	1618:1657	The compressive resistance failure point of GC31 group	1618:1671	The compressive resistance failure point of GC31 group was 1.10 kPa, while it was 7.33 kPa and 43.30 kPa for DN3131 and DN6262.
32071457	0	15	theme	cells	120:124	arg1	differentiation					83:97	differentiation	83:97	differentiation	83:97	[Effects of the injectable glycol-chitosan based hydrogel on the proliferation and differentiation of human dental pulp cells].
32071457	0	15	theme	cells	120:124	arg1	proliferation					65:77	proliferation	65:77	proliferation	65:77	[Effects of the injectable glycol-chitosan based hydrogel on the proliferation and differentiation of human dental pulp cells].
32071457	18	16	theme	dual-network	2734:2745	arg1	hydrogels					2747:2755	dual-network hydrogels	2734:2755	dual-network hydrogels	2734:2755	dual-network hydrogels had slower degradation rate and higher mechanical properties, in which hDPCs exhibited better odontoblastic differentiation potential and mineralization potential.
32071457	15	17	theme	DSPP	2015:2018	arg1	levels					2005:2010	The expression levels	1990:2010	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262)	1990:2086	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	15	17	theme	DSPP	2015:2018	arg1	higher					2107:2112	higher	2107:2112	higher	2107:2112	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	6	18	theme	CalceinAM/PI	906:918	arg1	assay					930:934	CalceinAM/PI Live/Dead assay	906:934	CalceinAM/PI Live/Dead assay	906:934	The proliferation of hDPCs in hydrogels was detected using the cell counting kit-8 (CCK-8) method and CalceinAM/PI Live/Dead assay.
32071457	4	19	with	loss	720:723	arg1	time					730:733	time	730:733	time	730:733	The degradation of the hydrogel was determined by the weight loss with time.
32071457	5	20	theme	universal	777:785	arg1	machine					795:801	a universal testing machine	775:801	a universal testing machine	775:801	The fracture stress was measured using a universal testing machine.
32071457	15	21	theme	Von	2272:2274	arg1	staining					2282:2289	Von Kossa staining	2272:2289	Von Kossa staining	2272:2289	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	1	22	theme	composition	221:231	arg1	GC31					241:244	GC31	241:244	GC31	241:244	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	1	22	theme	composition	221:231	arg1	ratios					233:238	different composition ratios	211:238	different composition ratios (GC31, DN3131 and DN6262)	211:264	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	1	22	theme	composition	221:231	arg1	DN6262					258:263	DN6262	258:263	DN6262	258:263	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	1	22	theme	composition	221:231	arg1	DN3131					247:252	DN3131	247:252	DN3131	247:252	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	16	23	theme	composition	2582:2592	arg1	ratios					2594:2599	different composition ratios	2572:2599	different composition ratios met the injectable requirements	2572:2631	CONCLUSION GC-based single/dual network hydrogels with different composition ratios met the injectable requirements.
32071457	15	24	from	levels	2005:2010	arg1	groups					2064:2069	the dual-network hydrogel groups	2038:2069	the dual-network hydrogel groups (DN3131, DN6262)	2038:2086	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	4	25	theme	hydrogel	682:689	arg1	degradation					663:673	The degradation	659:673	The degradation of the hydrogel	659:689	The degradation of the hydrogel was determined by the weight loss with time.
32071457	10	26	theme	dual-network	1507:1518	arg1	P<0.05					1537:1542	P<0.05	1537:1542	P<0.05	1537:1542	The degradation rate of GC31 hydrogel in vitro was significantly faster than that of the dual-network hydrogel groups (P<0.05).
32071457	10	26	theme	dual-network	1507:1518	arg1	groups					1529:1534	the dual-network hydrogel groups	1503:1534	the dual-network hydrogel groups (P<0.05)	1503:1543	The degradation rate of GC31 hydrogel in vitro was significantly faster than that of the dual-network hydrogel groups (P<0.05).
32071457	7	27	theme	phosphatase	1006:1016	arg1	expression					983:992	the expression	979:992	the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1)	979:1093	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	18	28	theme	degradation	2768:2778	arg1	rate					2780:2783	slower degradation rate	2761:2783	slower degradation rate	2761:2783	dual-network hydrogels had slower degradation rate and higher mechanical properties, in which hDPCs exhibited better odontoblastic differentiation potential and mineralization potential.
32071457	7	29	theme	odontoblastic	954:966	arg1	induction					968:976	odontoblastic induction	954:976	odontoblastic induction	954:976	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	6	30	theme	CCK-8	888:892	arg1	method					895:900	the cell counting kit-8 (CCK-8) method	863:900	the cell counting kit-8 (CCK-8) method	863:900	The proliferation of hDPCs in hydrogels was detected using the cell counting kit-8 (CCK-8) method and CalceinAM/PI Live/Dead assay.
32071457	15	31	from	DSPP	2015:2018	arg1	groups					2064:2069	the dual-network hydrogel groups	2038:2069	the dual-network hydrogel groups (DN3131, DN6262)	2038:2086	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	13	32	theme	dual-network	1774:1785	arg1	hydrogel					1787:1794	dual-network hydrogel	1774:1794	dual-network hydrogel	1774:1794	The compressive strength of dual-network hydrogel was significantly enhanced compared with single-network hydrogel.
32071457	16	33	theme	injectable	2609:2618	arg1	requirements					2620:2631	the injectable requirements	2605:2631	the injectable requirements	2605:2631	CONCLUSION GC-based single/dual network hydrogels with different composition ratios met the injectable requirements.
32071457	15	34	from	DMP-1	2021:2025	arg1	groups					2064:2069	the dual-network hydrogel groups	2038:2069	the dual-network hydrogel groups (DN3131, DN6262)	2038:2086	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	2	35	with	hydrogels	464:472	arg1	ratios					518:523	different composition ratios	496:523	different composition ratios	496:523	METHODS GC-based single-network hydrogels (GC31) and GC-based dual-network hydrogels (DN3131, DN6262) with different composition ratios were prepared.
32071457	15	36	theme	hydrogel	2055:2062	arg1	groups					2064:2069	the dual-network hydrogel groups	2038:2069	the dual-network hydrogel groups (DN3131, DN6262)	2038:2086	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	17	37	theme	GC31	2634:2637	arg1	group					2639:2643	GC31 group	2634:2643	GC31 group	2634:2643	GC31 group had a lower mechanical properties, in which hDPCs exhibited a higher proliferation rate.
32071457	15	38	from	ALP	2031:2033	arg1	groups					2064:2069	the dual-network hydrogel groups	2038:2069	the dual-network hydrogel groups (DN3131, DN6262)	2038:2086	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	7	39	theme	real-time	1161:1169	arg1	PCR					1156:1158	real-time quantitative reverse transcription PCR	1111:1158	real-time quantitative reverse transcription PCR (real-time RT-PCR)	1111:1177	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	7	39	theme	real-time	1161:1169	arg1	RT-PCR					1171:1176	real-time RT-PCR	1161:1176	real-time RT-PCR	1161:1176	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	2	40	theme	composition	506:516	arg1	ratios					518:523	different composition ratios	496:523	different composition ratios	496:523	METHODS GC-based single-network hydrogels (GC31) and GC-based dual-network hydrogels (DN3131, DN6262) with different composition ratios were prepared.
32071457	8	41	theme	groups	1282:1287	arg1	injectability					1255:1267	The injectability	1251:1267	The injectability of all three groups of hydrogels	1251:1300	RESULTS The injectability of all three groups of hydrogels was acceptable.
32071457	8	41	theme	groups	1282:1287	arg1	acceptable					1306:1315	acceptable	1306:1315	acceptable	1306:1315	RESULTS The injectability of all three groups of hydrogels was acceptable.
32071457	1	42	theme	human	345:349	arg1	pulp					358:361	human dental pulp	345:361	human dental pulp cell (hDPC) encapsulated	345:386	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	15	43	theme	mineralization	2308:2321	arg1	deposition					2323:2332	more mineralization deposition	2303:2332	more mineralization deposition	2303:2332	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	17	44	theme	lower	2651:2655	arg1	properties					2668:2677	a lower mechanical properties	2649:2677	a lower mechanical properties	2649:2677	GC31 group had a lower mechanical properties, in which hDPCs exhibited a higher proliferation rate.
32071457	8	45	theme	hydrogels	1292:1300	arg1	hydrogels					1292:1300	hydrogels	1292:1300	hydrogels	1292:1300	RESULTS The injectability of all three groups of hydrogels was acceptable.
32071457	8	45	theme	hydrogels	1292:1300	arg1	groups					1282:1287	all three groups	1272:1287	all three groups of hydrogels	1272:1300	RESULTS The injectability of all three groups of hydrogels was acceptable.
32071457	17	46	theme	proliferation	2714:2726	arg1	rate					2728:2731	a higher proliferation rate	2705:2731	a higher proliferation rate	2705:2731	GC31 group had a lower mechanical properties, in which hDPCs exhibited a higher proliferation rate.
32071457	0	47	theme	dental	108:113	arg1	cells					120:124	human dental pulp cells	102:124	human dental pulp cells	102:124	[Effects of the injectable glycol-chitosan based hydrogel on the proliferation and differentiation of human dental pulp cells].
32071457	1	48	theme	pulp	358:361	arg1	behavior					333:340	biological behavior	322:340	biological behavior of human dental pulp cell (hDPC) encapsulated	322:386	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	14	49	theme	proliferation	1961:1973	arg1	rate					1975:1978	a higher proliferation rate	1952:1978	a higher proliferation rate (P<0.05)	1952:1987	hDPCs were in continuous proliferation in all the three groups, and the GC31 group showed a higher proliferation rate (P<0.05).
32071457	14	49	theme	proliferation	1961:1973	arg1	P<0.05					1981:1986	P<0.05	1981:1986	P<0.05	1981:1986	hDPCs were in continuous proliferation in all the three groups, and the GC31 group showed a higher proliferation rate (P<0.05).
32071457	7	50	theme	real-time	1111:1119	arg1	PCR					1156:1158	real-time quantitative reverse transcription PCR	1111:1158	real-time quantitative reverse transcription PCR (real-time RT-PCR)	1111:1177	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	7	50	theme	real-time	1111:1119	arg1	RT-PCR					1171:1176	real-time RT-PCR	1161:1176	real-time RT-PCR	1161:1176	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	18	51	theme	odontoblastic	2851:2863	arg1	potential					2881:2889	differentiation potential	2865:2889	differentiation potential	2865:2889	dual-network hydrogels had slower degradation rate and higher mechanical properties, in which hDPCs exhibited better odontoblastic differentiation potential and mineralization potential.
32071457	14	52	from	proliferation	1887:1899	arg1	groups					1918:1923	all the three groups	1904:1923	all the three groups	1904:1923	hDPCs were in continuous proliferation in all the three groups, and the GC31 group showed a higher proliferation rate (P<0.05).
32071457	14	53	theme	continuous	1876:1885	arg1	proliferation					1887:1899	continuous proliferation	1876:1899	continuous proliferation in all the three groups	1876:1923	hDPCs were in continuous proliferation in all the three groups, and the GC31 group showed a higher proliferation rate (P<0.05).
32071457	2	54	theme	single-network	406:419	arg1	GC31					432:435	GC31	432:435	GC31	432:435	METHODS GC-based single-network hydrogels (GC31) and GC-based dual-network hydrogels (DN3131, DN6262) with different composition ratios were prepared.
32071457	2	54	theme	single-network	406:419	arg1	hydrogels					421:429	single-network hydrogels	406:429	single-network hydrogels (GC31)	406:436	METHODS GC-based single-network hydrogels (GC31) and GC-based dual-network hydrogels (DN3131, DN6262) with different composition ratios were prepared.
32071457	5	55	theme	testing	787:793	arg1	machine					795:801	a universal testing machine	775:801	a universal testing machine	775:801	The fracture stress was measured using a universal testing machine.
32071457	16	56	theme	CONCLUSION	2517:2526	arg1	network					2549:2555	CONCLUSION GC-based single/dual network	2517:2555	CONCLUSION GC-based single/dual network	2517:2555	CONCLUSION GC-based single/dual network hydrogels with different composition ratios met the injectable requirements.
32071457	3	57	theme	hydrogel	626:633	arg1	volume					616:621	a certain volume	606:621	a certain volume of hydrogel	606:633	The injectability was defined as the average time needed to expel a certain volume of hydrogel under a constant force.
32071457	0	58	theme	glycol-chitosan	27:41	arg1	[Effects					0:7	[Effects	0:7	[Effects of the injectable glycol-chitosan	0:41	[Effects of the injectable glycol-chitosan based hydrogel on the proliferation and differentiation of human dental pulp cells].
32071457	18	59	theme	mineralization	2895:2908	arg1	potential					2910:2918	mineralization potential	2895:2918	mineralization potential	2895:2918	dual-network hydrogels had slower degradation rate and higher mechanical properties, in which hDPCs exhibited better odontoblastic differentiation potential and mineralization potential.
32071457	6	60	theme	hDPCs	825:829	arg1	proliferation					808:820	The proliferation	804:820	The proliferation of hDPCs in hydrogels	804:842	The proliferation of hDPCs in hydrogels was detected using the cell counting kit-8 (CCK-8) method and CalceinAM/PI Live/Dead assay.
32071457	16	61	theme	single/dual	2537:2547	arg1	network					2549:2555	CONCLUSION GC-based single/dual network	2517:2555	CONCLUSION GC-based single/dual network	2517:2555	CONCLUSION GC-based single/dual network hydrogels with different composition ratios met the injectable requirements.
32071457	2	62	theme	GC-based	442:449	arg1	hydrogels					464:472	GC-based dual-network hydrogels	442:472	GC-based dual-network hydrogels (DN3131, DN6262)	442:489	METHODS GC-based single-network hydrogels (GC31) and GC-based dual-network hydrogels (DN3131, DN6262) with different composition ratios were prepared.
32071457	15	63	theme	granular	2501:2508	arg1	forms					2510:2514	granular forms	2501:2514	granular forms	2501:2514	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	1	64	theme	hydrogel	300:307	arg1	scaffolds					309:317	hydrogel scaffolds	300:317	hydrogel scaffolds	300:317	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	16	65	dep	ratios	2594:2599	arg1	met					2601:2603	met	2601:2603	met	2601:2603	CONCLUSION GC-based single/dual network hydrogels with different composition ratios met the injectable requirements.
32071457	7	66	theme	Von	1223:1225	arg1	staining					1233:1240	Von Kossa staining	1223:1240	Von Kossa staining	1223:1240	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	15	67	located	observed	2454:2461	arg1	group					2471:2475	GC31 group	2466:2475	GC31 group	2466:2475	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	15	67	located	observed	2454:2461	arg2	staining					2441:2448	only light brown calcium deposition staining	2405:2448	only light brown calcium deposition staining	2405:2448	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	18	68	theme	mechanical	2796:2805	arg1	properties					2807:2816	higher mechanical properties	2789:2816	higher mechanical properties	2789:2816	dual-network hydrogels had slower degradation rate and higher mechanical properties, in which hDPCs exhibited better odontoblastic differentiation potential and mineralization potential.
32071457	9	69	theme	injection	1330:1338	arg1	time					1322:1325	The time	1318:1325	The time of injection of GC31	1318:1346	The time of injection of GC31 was the shortest, and that of DN6262 was longer than DN3131 (P<0.05).
32071457	9	69	theme	injection	1330:1338	arg1	shortest					1356:1363	shortest	1356:1363	shortest	1356:1363	The time of injection of GC31 was the shortest, and that of DN6262 was longer than DN3131 (P<0.05).
32071457	15	70	dep	higher	2107:2112	arg1	was					2176:2178	was	2176:2178	was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05)	2176:2269	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	10	71	theme	GC31	1442:1445	arg1	hydrogel					1447:1454	GC31 hydrogel	1442:1454	GC31 hydrogel	1442:1454	The degradation rate of GC31 hydrogel in vitro was significantly faster than that of the dual-network hydrogel groups (P<0.05).
32071457	7	72	theme	dentin	1063:1068	arg1	DMP-1					1088:1092	DMP-1	1088:1092	DMP-1	1088:1092	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	7	72	theme	dentin	1063:1068	arg1	protein-1					1077:1085	dentin matrix protein-1	1063:1085	dentin matrix protein-1 (DMP-1)	1063:1093	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	9	73	theme	GC31	1343:1346	arg1	injection					1330:1338	injection	1330:1338	injection of GC31	1330:1346	The time of injection of GC31 was the shortest, and that of DN6262 was longer than DN3131 (P<0.05).
32071457	6	74	theme	counting	872:879	arg1	method					895:900	the cell counting kit-8 (CCK-8) method	863:900	the cell counting kit-8 (CCK-8) method	863:900	The proliferation of hDPCs in hydrogels was detected using the cell counting kit-8 (CCK-8) method and CalceinAM/PI Live/Dead assay.
32071457	1	75	from	effects	289:295	arg1	behavior					333:340	biological behavior	322:340	biological behavior of human dental pulp cell (hDPC) encapsulated	322:386	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	17	76	contain	had	2645:2647	arg2	properties					2668:2677	a lower mechanical properties	2649:2677	a lower mechanical properties	2649:2677	GC31 group had a lower mechanical properties, in which hDPCs exhibited a higher proliferation rate.
32071457	17	76	contain	had	2645:2647	arg1	group					2639:2643	GC31 group	2634:2643	GC31 group	2634:2643	GC31 group had a lower mechanical properties, in which hDPCs exhibited a higher proliferation rate.
32071457	2	77	with	METHODS	389:395	arg1	ratios					518:523	different composition ratios	496:523	different composition ratios	496:523	METHODS GC-based single-network hydrogels (GC31) and GC-based dual-network hydrogels (DN3131, DN6262) with different composition ratios were prepared.
32071457	12	78	theme	group	1667:1671	arg1	kPa					1682:1684	1.10 kPa	1677:1684	1.10 kPa	1677:1684	The compressive resistance failure point of GC31 group was 1.10 kPa, while it was 7.33 kPa and 43.30 kPa for DN3131 and DN6262.
32071457	12	78	theme	group	1667:1671	arg1	point					1653:1657	The compressive resistance failure point	1618:1657	The compressive resistance failure point of GC31 group	1618:1671	The compressive resistance failure point of GC31 group was 1.10 kPa, while it was 7.33 kPa and 43.30 kPa for DN3131 and DN6262.
32071457	12	79	theme	compressive	1622:1632	arg1	kPa					1682:1684	1.10 kPa	1677:1684	1.10 kPa	1677:1684	The compressive resistance failure point of GC31 group was 1.10 kPa, while it was 7.33 kPa and 43.30 kPa for DN3131 and DN6262.
32071457	12	79	theme	compressive	1622:1632	arg1	point					1653:1657	The compressive resistance failure point	1618:1657	The compressive resistance failure point of GC31 group	1618:1671	The compressive resistance failure point of GC31 group was 1.10 kPa, while it was 7.33 kPa and 43.30 kPa for DN3131 and DN6262.
32071457	7	80	theme	dentin	1025:1030	arg1	DSPP					1053:1056	DSPP	1053:1056	DSPP	1053:1056	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	7	80	theme	dentin	1025:1030	arg1	sialophosphoprotein					1032:1050	dentin sialophosphoprotein	1025:1050	dentin sialophosphoprotein (DSPP)	1025:1057	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	15	81	theme	deposition	2430:2439	arg1	staining					2441:2448	only light brown calcium deposition staining	2405:2448	only light brown calcium deposition staining	2405:2448	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	1	82	theme	-based	169:174	arg1	hydrogels					196:204	glycol-chitosan (GC)-based single/dual-network hydrogels	149:204	glycol-chitosan (GC)-based single/dual-network hydrogels	149:204	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	12	83	theme	failure	1645:1651	arg1	kPa					1682:1684	1.10 kPa	1677:1684	1.10 kPa	1677:1684	The compressive resistance failure point of GC31 group was 1.10 kPa, while it was 7.33 kPa and 43.30 kPa for DN3131 and DN6262.
32071457	12	83	theme	failure	1645:1651	arg1	point					1653:1657	The compressive resistance failure point	1618:1657	The compressive resistance failure point of GC31 group	1618:1671	The compressive resistance failure point of GC31 group was 1.10 kPa, while it was 7.33 kPa and 43.30 kPa for DN3131 and DN6262.
32071457	15	84	theme	brown	2416:2420	arg1	staining					2441:2448	only light brown calcium deposition staining	2405:2448	only light brown calcium deposition staining	2405:2448	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	6	85	theme	Live/Dead	920:928	arg1	assay					930:934	CalceinAM/PI Live/Dead assay	906:934	CalceinAM/PI Live/Dead assay	906:934	The proliferation of hDPCs in hydrogels was detected using the cell counting kit-8 (CCK-8) method and CalceinAM/PI Live/Dead assay.
32071457	3	86	theme	average	577:583	arg1	injectability					544:556	The injectability	540:556	The injectability	540:556	The injectability was defined as the average time needed to expel a certain volume of hydrogel under a constant force.
32071457	3	86	theme	average	577:583	arg1	time					585:588	the average time	573:588	the average time needed to expel a certain volume of hydrogel under a constant force	573:656	The injectability was defined as the average time needed to expel a certain volume of hydrogel under a constant force.
32071457	15	87	theme	DMP-1	2021:2025	arg1	levels					2005:2010	The expression levels	1990:2010	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262)	1990:2086	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	15	87	theme	DMP-1	2021:2025	arg1	higher					2107:2112	higher	2107:2112	higher	2107:2112	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	1	88	theme	different	211:219	arg1	GC31					241:244	GC31	241:244	GC31	241:244	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	1	88	theme	different	211:219	arg1	ratios					233:238	different composition ratios	211:238	different composition ratios (GC31, DN3131 and DN6262)	211:264	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	1	88	theme	different	211:219	arg1	DN6262					258:263	DN6262	258:263	DN6262	258:263	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	1	88	theme	different	211:219	arg1	DN3131					247:252	DN3131	247:252	DN3131	247:252	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	1	89	dep	ratios	233:238	arg1	GC31					241:244	GC31	241:244	GC31	241:244	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	1	89	dep	ratios	233:238	arg1	ratios					233:238	different composition ratios	211:238	different composition ratios (GC31, DN3131 and DN6262)	211:264	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	1	89	dep	ratios	233:238	arg1	DN6262					258:263	DN6262	258:263	DN6262	258:263	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	1	89	dep	ratios	233:238	arg1	DN3131					247:252	DN3131	247:252	DN3131	247:252	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	18	90	theme	differentiation	2865:2879	arg1	potential					2881:2889	differentiation potential	2865:2889	differentiation potential	2865:2889	dual-network hydrogels had slower degradation rate and higher mechanical properties, in which hDPCs exhibited better odontoblastic differentiation potential and mineralization potential.
32071457	10	91	theme	hydrogel	1520:1527	arg1	P<0.05					1537:1542	P<0.05	1537:1542	P<0.05	1537:1542	The degradation rate of GC31 hydrogel in vitro was significantly faster than that of the dual-network hydrogel groups (P<0.05).
32071457	10	91	theme	hydrogel	1520:1527	arg1	groups					1529:1534	the dual-network hydrogel groups	1503:1534	the dual-network hydrogel groups (P<0.05)	1503:1543	The degradation rate of GC31 hydrogel in vitro was significantly faster than that of the dual-network hydrogel groups (P<0.05).
32071457	7	92	theme	transcription	1142:1154	arg1	PCR					1156:1158	real-time quantitative reverse transcription PCR	1111:1158	real-time quantitative reverse transcription PCR (real-time RT-PCR)	1111:1177	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	7	92	theme	transcription	1142:1154	arg1	RT-PCR					1171:1176	real-time RT-PCR	1161:1176	real-time RT-PCR	1161:1176	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	7	93	theme	alkaline	997:1004	arg1	ALP					1019:1021	ALP	1019:1021	ALP	1019:1021	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	7	93	theme	alkaline	997:1004	arg1	phosphatase					1006:1016	alkaline phosphatase	997:1016	alkaline phosphatase (ALP)	997:1022	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	1	94	theme	encapsulated	375:386	arg1	pulp					358:361	human dental pulp	345:361	human dental pulp cell (hDPC) encapsulated	345:386	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	15	95	theme	Kossa	2276:2280	arg1	staining					2282:2289	Von Kossa staining	2272:2289	Von Kossa staining	2272:2289	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	16	96	theme	different	2572:2580	arg1	ratios					2594:2599	different composition ratios	2572:2599	different composition ratios met the injectable requirements	2572:2631	CONCLUSION GC-based single/dual network hydrogels with different composition ratios met the injectable requirements.
32071457	18	97	theme	slower	2761:2766	arg1	rate					2780:2783	slower degradation rate	2761:2783	slower degradation rate	2761:2783	dual-network hydrogels had slower degradation rate and higher mechanical properties, in which hDPCs exhibited better odontoblastic differentiation potential and mineralization potential.
32071457	7	98	theme	induction	968:976	arg1	days					946:949	14 days	943:949	14 days of odontoblastic induction	943:976	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	13	99	theme	hydrogel	1787:1794	arg1	strength					1762:1769	The compressive strength	1746:1769	The compressive strength of dual-network hydrogel	1746:1794	The compressive strength of dual-network hydrogel was significantly enhanced compared with single-network hydrogel.
32071457	15	100	theme	dual-network	2042:2053	arg1	groups					2064:2069	the dual-network hydrogel groups	2038:2069	the dual-network hydrogel groups (DN3131, DN6262)	2038:2086	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	1	101	theme	biological	322:331	arg1	behavior					333:340	biological behavior	322:340	biological behavior of human dental pulp cell (hDPC) encapsulated	322:386	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	13	102	theme	compressive	1750:1760	arg1	strength					1762:1769	The compressive strength	1746:1769	The compressive strength of dual-network hydrogel	1746:1794	The compressive strength of dual-network hydrogel was significantly enhanced compared with single-network hydrogel.
32071457	0	103	theme	human	102:106	arg1	cells					120:124	human dental pulp cells	102:124	human dental pulp cells	102:124	[Effects of the injectable glycol-chitosan based hydrogel on the proliferation and differentiation of human dental pulp cells].
32071457	15	104	theme	ALP	2232:2234	arg1	levels					2212:2217	the expression levels	2197:2217	the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05)	2197:2269	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	2	105	dep	hydrogels	464:472	arg1	DN6262					483:488	DN6262	483:488	DN6262	483:488	METHODS GC-based single-network hydrogels (GC31) and GC-based dual-network hydrogels (DN3131, DN6262) with different composition ratios were prepared.
32071457	15	106	theme	mass-shaped	2338:2348	arg1	nodules					2362:2368	mass-shaped mineralized nodules	2338:2368	mass-shaped mineralized nodules	2338:2368	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	2	107	theme	different	496:504	arg1	ratios					518:523	different composition ratios	496:523	different composition ratios	496:523	METHODS GC-based single-network hydrogels (GC31) and GC-based dual-network hydrogels (DN3131, DN6262) with different composition ratios were prepared.
32071457	0	108	theme	pulp	115:118	arg1	cells					120:124	human dental pulp cells	102:124	human dental pulp cells	102:124	[Effects of the injectable glycol-chitosan based hydrogel on the proliferation and differentiation of human dental pulp cells].
32071457	1	109	theme	dental	351:356	arg1	pulp					358:361	human dental pulp	345:361	human dental pulp cell (hDPC) encapsulated	345:386	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	18	110	contain	had	2757:2759	arg2	rate					2780:2783	slower degradation rate	2761:2783	slower degradation rate	2761:2783	dual-network hydrogels had slower degradation rate and higher mechanical properties, in which hDPCs exhibited better odontoblastic differentiation potential and mineralization potential.
32071457	18	110	contain	had	2757:2759	arg2	properties					2807:2816	higher mechanical properties	2789:2816	higher mechanical properties	2789:2816	dual-network hydrogels had slower degradation rate and higher mechanical properties, in which hDPCs exhibited better odontoblastic differentiation potential and mineralization potential.
32071457	18	110	contain	had	2757:2759	arg1	hydrogels					2747:2755	dual-network hydrogels	2734:2755	dual-network hydrogels	2734:2755	dual-network hydrogels had slower degradation rate and higher mechanical properties, in which hDPCs exhibited better odontoblastic differentiation potential and mineralization potential.
32071457	17	111	theme	mechanical	2657:2666	arg1	properties					2668:2677	a lower mechanical properties	2649:2677	a lower mechanical properties	2649:2677	GC31 group had a lower mechanical properties, in which hDPCs exhibited a higher proliferation rate.
32071457	15	112	from	groups	2064:2069	arg1	levels					2005:2010	The expression levels	1990:2010	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262)	1990:2086	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	15	112	from	groups	2064:2069	arg1	higher					2107:2112	higher	2107:2112	higher	2107:2112	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	7	113	theme	quantitative	1121:1132	arg1	PCR					1156:1158	real-time quantitative reverse transcription PCR	1111:1158	real-time quantitative reverse transcription PCR (real-time RT-PCR)	1111:1177	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	7	113	theme	quantitative	1121:1132	arg1	RT-PCR					1171:1176	real-time RT-PCR	1161:1176	real-time RT-PCR	1161:1176	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	15	114	theme	more	2303:2306	arg1	deposition					2323:2332	more mineralization deposition	2303:2332	more mineralization deposition	2303:2332	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	15	115	theme	DMP-1	2222:2226	arg1	levels					2212:2217	the expression levels	2197:2217	the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05)	2197:2269	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	14	116	theme	higher	1954:1959	arg1	rate					1975:1978	a higher proliferation rate	1952:1978	a higher proliferation rate (P<0.05)	1952:1987	hDPCs were in continuous proliferation in all the three groups, and the GC31 group showed a higher proliferation rate (P<0.05).
32071457	14	116	theme	higher	1954:1959	arg1	P<0.05					1981:1986	P<0.05	1981:1986	P<0.05	1981:1986	hDPCs were in continuous proliferation in all the three groups, and the GC31 group showed a higher proliferation rate (P<0.05).
32071457	0	117	theme	injectable	16:25	arg1	glycol-chitosan					27:41	the injectable glycol-chitosan	12:41	the injectable glycol-chitosan	12:41	[Effects of the injectable glycol-chitosan based hydrogel on the proliferation and differentiation of human dental pulp cells].
32071457	0	118	dep	proliferation	65:77	arg1	the					61:63	the	61:63	the	61:63	[Effects of the injectable glycol-chitosan based hydrogel on the proliferation and differentiation of human dental pulp cells].
32071457	16	119	theme	GC-based	2528:2535	arg1	network					2549:2555	CONCLUSION GC-based single/dual network	2517:2555	CONCLUSION GC-based single/dual network	2517:2555	CONCLUSION GC-based single/dual network hydrogels with different composition ratios met the injectable requirements.
32071457	4	120	theme	weight	713:718	arg1	loss					720:723	the weight loss	709:723	the weight loss with time	709:733	The degradation of the hydrogel was determined by the weight loss with time.
32071457	2	121	theme	GC-based	397:404	arg1	METHODS					389:395	METHODS	389:395	METHODS GC-based single-network hydrogels (GC31)	389:436	METHODS GC-based single-network hydrogels (GC31) and GC-based dual-network hydrogels (DN3131, DN6262) with different composition ratios were prepared.
32071457	5	122	theme	fracture	740:747	arg1	stress					749:754	The fracture stress	736:754	The fracture stress	736:754	The fracture stress was measured using a universal testing machine.
32071457	15	123	theme	expression	1994:2003	arg1	levels					2005:2010	The expression levels	1990:2010	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262)	1990:2086	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	15	123	theme	expression	1994:2003	arg1	higher					2107:2112	higher	2107:2112	higher	2107:2112	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	7	124	theme	Kossa	1227:1231	arg1	staining					1233:1240	Von Kossa staining	1223:1240	Von Kossa staining	1223:1240	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	2	125	theme	dual-network	451:462	arg1	hydrogels					464:472	GC-based dual-network hydrogels	442:472	GC-based dual-network hydrogels (DN3131, DN6262)	442:489	METHODS GC-based single-network hydrogels (GC31) and GC-based dual-network hydrogels (DN3131, DN6262) with different composition ratios were prepared.
32071457	14	126	theme	GC31	1934:1937	arg1	group					1939:1943	the GC31 group	1930:1943	the GC31 group	1930:1943	hDPCs were in continuous proliferation in all the three groups, and the GC31 group showed a higher proliferation rate (P<0.05).
32071457	3	127	theme	certain	608:614	arg1	volume					616:621	a certain volume	606:621	a certain volume of hydrogel	606:633	The injectability was defined as the average time needed to expel a certain volume of hydrogel under a constant force.
32071457	7	128	theme	reverse	1134:1140	arg1	PCR					1156:1158	real-time quantitative reverse transcription PCR	1111:1158	real-time quantitative reverse transcription PCR (real-time RT-PCR)	1111:1177	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	7	128	theme	reverse	1134:1140	arg1	RT-PCR					1171:1176	real-time RT-PCR	1161:1176	real-time RT-PCR	1161:1176	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	7	129	theme	protein-1	1077:1085	arg1	expression					983:992	the expression	979:992	the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1)	979:1093	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	10	130	theme	hydrogel	1447:1454	arg1	faster					1483:1488	faster	1483:1488	faster	1483:1488	The degradation rate of GC31 hydrogel in vitro was significantly faster than that of the dual-network hydrogel groups (P<0.05).
32071457	10	130	theme	hydrogel	1447:1454	arg1	rate					1434:1437	The degradation rate	1418:1437	The degradation rate of GC31 hydrogel in vitro	1418:1463	The degradation rate of GC31 hydrogel in vitro was significantly faster than that of the dual-network hydrogel groups (P<0.05).
32071457	15	131	theme	expression	2201:2210	arg1	levels					2212:2217	the expression levels	2197:2217	the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05)	2197:2269	The expression levels of DSPP, DMP-1 and ALP in the dual-network hydrogel groups (DN3131, DN6262) were significantly higher than that of GC31 after culturing for 14 days (P<0.05), there was no difference in the expression levels of DMP-1 and ALP between DN3131 and DN6262 (P>0.05); Von Kossa staining showed that more mineralization deposition and mass-shaped mineralized nodules formed in DN3131 and DN6262, while only light brown calcium deposition staining was observed in GC31 group, which was scattered in granular forms.
32071457	10	132	theme	degradation	1422:1432	arg1	faster					1483:1488	faster	1483:1488	faster	1483:1488	The degradation rate of GC31 hydrogel in vitro was significantly faster than that of the dual-network hydrogel groups (P<0.05).
32071457	10	132	theme	degradation	1422:1432	arg1	rate					1434:1437	The degradation rate	1418:1437	The degradation rate of GC31 hydrogel in vitro	1418:1463	The degradation rate of GC31 hydrogel in vitro was significantly faster than that of the dual-network hydrogel groups (P<0.05).
32071457	3	133	theme	constant	643:650	arg1	force					652:656	a constant force	641:656	a constant force	641:656	The injectability was defined as the average time needed to expel a certain volume of hydrogel under a constant force.
32071457	2	134	dep	GC-based	397:404	arg1	GC31					432:435	GC31	432:435	GC31	432:435	METHODS GC-based single-network hydrogels (GC31) and GC-based dual-network hydrogels (DN3131, DN6262) with different composition ratios were prepared.
32071457	2	134	dep	GC-based	397:404	arg1	hydrogels					421:429	single-network hydrogels	406:429	single-network hydrogels (GC31)	406:436	METHODS GC-based single-network hydrogels (GC31) and GC-based dual-network hydrogels (DN3131, DN6262) with different composition ratios were prepared.
32071457	1	135	theme	scaffolds	309:317	arg1	effects					289:295	the effects	285:295	the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated	285:386	OBJECTIVE To prepare glycol-chitosan (GC)-based single/dual-network hydrogels with different composition ratios (GC31, DN3131 and DN6262) and to investigate the effects of hydrogel scaffolds on biological behavior of human dental pulp cell (hDPC) encapsulated.
32071457	8	136	dep	RESULTS	1243:1249	arg1	acceptable					1306:1315	acceptable	1306:1315	acceptable	1306:1315	RESULTS The injectability of all three groups of hydrogels was acceptable.
32071457	8	136	dep	RESULTS	1243:1249	arg1	injectability					1255:1267	The injectability	1251:1267	The injectability of all three groups of hydrogels	1251:1300	RESULTS The injectability of all three groups of hydrogels was acceptable.
32071457	18	137	theme	higher	2789:2794	arg1	properties					2807:2816	higher mechanical properties	2789:2816	higher mechanical properties	2789:2816	dual-network hydrogels had slower degradation rate and higher mechanical properties, in which hDPCs exhibited better odontoblastic differentiation potential and mineralization potential.
32071457	7	138	theme	mineralized	1187:1197	arg1	nodules					1199:1205	the mineralized nodules	1183:1205	the mineralized nodules	1183:1205	After 14 days of odontoblastic induction, the expression of alkaline phosphatase (ALP), dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) was detected by real-time quantitative reverse transcription PCR (real-time RT-PCR) and the mineralized nodules was observed by Von Kossa staining.
32071457	6	139	from	proliferation	808:820	arg1	hydrogels					834:842	hydrogels	834:842	hydrogels	834:842	The proliferation of hDPCs in hydrogels was detected using the cell counting kit-8 (CCK-8) method and CalceinAM/PI Live/Dead assay.
33169014	4	0	from	modification	630:641	arg1	IgGs					694:697	severe acute respiratory syndrome coronavirus 2 IgGs	646:697	severe acute respiratory syndrome coronavirus 2 IgGs	646:697	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	4	1	theme	Fcγ	741:743	arg1	FcγRIIIa					754:761	the activating Fcγ receptor FcγRIIIa	726:761	the activating Fcγ receptor FcγRIIIa	726:761	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	2	2	theme	high	363:366	arg1	levels					368:373	high levels	363:373	high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi	363:460	Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi.
33169014	5	3	theme	disease	957:963	arg1	severity					965:972	disease severity	957:972	disease severity in COVID-19	957:984	These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
33169014	3	4	theme	serologic	529:537	arg1	signature					539:547	a unique serologic signature	520:547	a unique serologic signature	520:547	Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans.
33169014	1	5	theme	life-threatening	238:253	arg1	pneumonia					255:263	life-threatening pneumonia	238:263	life-threatening pneumonia	238:263	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	5	6	theme	afucosylated	1063:1074	arg1	IgG1					1076:1079	afucosylated IgG1	1063:1079	afucosylated IgG1	1063:1079	These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
33169014	5	7	from	severity	965:972	arg1	COVID-19					977:984	COVID-19	977:984	COVID-19	977:984	These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
33169014	2	8	theme	Severe	290:295	arg1	COVID-19					297:304	Severe COVID-19	290:304	Severe COVID-19	290:304	Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi.
33169014	4	9	theme	immune	787:792	arg1	complexes					794:802	immune complexes	787:802	immune complexes	787:802	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	5	10	theme	Fc	1038:1039	arg1	IgG1					1076:1079	afucosylated IgG1	1063:1079	afucosylated IgG1	1063:1079	These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
33169014	5	10	theme	Fc	1038:1039	arg1	structures					1041:1050	proinflammatory IgG Fc structures	1018:1050	proinflammatory IgG Fc structures	1018:1050	These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
33169014	3	11	theme	unique	522:527	arg1	signature					539:547	a unique serologic signature	520:547	a unique serologic signature	520:547	Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans.
33169014	4	12	theme	coronavirus	680:690	arg1	IgGs					694:697	severe acute respiratory syndrome coronavirus 2 IgGs	646:697	severe acute respiratory syndrome coronavirus 2 IgGs	646:697	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	4	13	theme	activating	730:739	arg1	FcγRIIIa					754:761	the activating Fcγ receptor FcγRIIIa	726:761	the activating Fcγ receptor FcγRIIIa	726:761	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	1	14	theme	Severe	68:73	arg1	coronavirus					102:112	Severe acute respiratory syndrome coronavirus 2	68:114	Severe acute respiratory syndrome coronavirus 2 infections	68:125	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	2	15	theme	alveolar	402:409	arg1	infiltrates					424:434	alveolar inflammatory infiltrates	402:434	alveolar inflammatory infiltrates	402:434	Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi.
33169014	1	16	theme	acute	75:79	arg1	coronavirus					102:112	Severe acute respiratory syndrome coronavirus 2	68:114	Severe acute respiratory syndrome coronavirus 2 infections	68:125	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	0	17	theme	IgG	16:18	arg1	structures					23:32	Proinflammatory IgG Fc structures	0:32	Proinflammatory IgG Fc structures in patients with severe COVID-19	0:65	Proinflammatory IgG Fc structures in patients with severe COVID-19.
33169014	4	18	theme	necrosis	916:923	arg1	factor					925:930	tumor necrosis factor	910:930	tumor necrosis factor	910:930	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	1	19	theme	respiratory	81:91	arg1	coronavirus					102:112	Severe acute respiratory syndrome coronavirus 2	68:114	Severe acute respiratory syndrome coronavirus 2 infections	68:125	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	2	20	theme	cytokines	391:399	arg1	levels					368:373	high levels	363:373	high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi	363:460	Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi.
33169014	0	21	theme	Proinflammatory	0:14	arg1	structures					23:32	Proinflammatory IgG Fc structures	0:32	Proinflammatory IgG Fc structures in patients with severe COVID-19	0:65	Proinflammatory IgG Fc structures in patients with severe COVID-19.
33169014	1	22	theme	multi-organ	269:279	arg1	failure					281:287	multi-organ failure	269:287	multi-organ failure	269:287	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	1	23	from	failure	281:287	arg1	severities					206:215	severities	206:215	severities from mild illness to life-threatening pneumonia and multi-organ failure	206:287	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	1	23	from	failure	281:287	arg1	range					197:201	a range	195:201	a range of severities from mild illness to life-threatening pneumonia and multi-organ failure	195:287	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	1	24	theme	syndrome	93:100	arg1	coronavirus					102:112	Severe acute respiratory syndrome coronavirus 2	68:114	Severe acute respiratory syndrome coronavirus 2 infections	68:125	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	4	25	theme	Fc	805:806	arg1	afucosylation					808:820	Fc afucosylation	805:820	Fc afucosylation	805:820	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	2	26	theme	inflammatory	378:389	arg1	cytokines					391:399	inflammatory cytokines	378:399	inflammatory cytokines	378:399	Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi.
33169014	1	27	theme	coronavirus	102:112	arg1	infections					116:125	Severe acute respiratory syndrome coronavirus 2 infections	68:125	Severe acute respiratory syndrome coronavirus 2 infections	68:125	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	2	28	theme	vascular	440:447	arg1	microthrombi					449:460	vascular microthrombi	440:460	vascular microthrombi	440:460	Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi.
33169014	2	29	theme	microthrombi	449:460	arg1	levels					368:373	high levels	363:373	high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi	363:460	Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi.
33169014	3	30	dep	produced	511:518	arg1	including					550:558	including	550:558	including an increased likelihood of IgG1 with afucosylated Fc glycans	550:619	Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans.
33169014	4	31	with	interactions	708:719	arg1	FcγRIIIa					754:761	the activating Fcγ receptor FcγRIIIa	726:761	the activating Fcγ receptor FcγRIIIa	726:761	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	3	32	theme	IgG1	587:590	arg1	likelihood					573:582	an increased likelihood	560:582	an increased likelihood of IgG1 with afucosylated Fc glycans	560:619	Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans.
33169014	4	33	theme	acute	653:657	arg1	coronavirus					680:690	severe acute respiratory syndrome coronavirus 2	646:692	severe acute respiratory syndrome coronavirus 2 IgGs	646:697	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	5	34	gly	afucosylated	1063:1074	arg1	IgG1					1076:1079	afucosylated IgG1	1063:1079	afucosylated IgG1	1063:1079	These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
33169014	5	35	theme	IgG	1034:1036	arg1	IgG1					1076:1079	afucosylated IgG1	1063:1079	afucosylated IgG1	1063:1079	These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
33169014	5	35	theme	IgG	1034:1036	arg1	structures					1041:1050	proinflammatory IgG Fc structures	1018:1050	proinflammatory IgG Fc structures	1018:1050	These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
33169014	3	36	with	patients	481:488	arg1	COVID-19					502:509	severe COVID-19	495:509	severe COVID-19	495:509	Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans.
33169014	1	37	dep	illness	227:233	arg1	pneumonia					255:263	life-threatening pneumonia	238:263	life-threatening pneumonia	238:263	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	1	37	dep	illness	227:233	arg1	to					235:236	to	235:236	to	235:236	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	2	38	theme	infiltrates	424:434	arg1	levels					368:373	high levels	363:373	high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi	363:460	Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi.
33169014	4	39	theme	severe	646:651	arg1	coronavirus					680:690	severe acute respiratory syndrome coronavirus 2	646:692	severe acute respiratory syndrome coronavirus 2 IgGs	646:697	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	1	40	from	range	197:201	arg1	illness					227:233	mild illness	222:233	mild illness	222:233	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	1	40	from	range	197:201	arg1	failure					281:287	multi-organ failure	269:287	multi-organ failure	269:287	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	2	41	theme	inflammatory	411:422	arg1	infiltrates					424:434	alveolar inflammatory infiltrates	402:434	alveolar inflammatory infiltrates	402:434	Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi.
33169014	0	42	theme	severe	51:56	arg1	COVID-19					58:65	severe COVID-19	51:65	severe COVID-19	51:65	Proinflammatory IgG Fc structures in patients with severe COVID-19.
33169014	5	43	theme	structures	1041:1050	arg1	presence					1006:1013	the presence	1002:1013	the presence of proinflammatory IgG Fc structures, including afucosylated IgG1	1002:1079	These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
33169014	3	44	theme	Fc	610:611	arg1	glycans					613:619	afucosylated Fc glycans	597:619	afucosylated Fc glycans	597:619	Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans.
33169014	4	45	theme	tumor	910:914	arg1	factor					925:930	tumor necrosis factor	910:930	tumor necrosis factor	910:930	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	3	46	gly	afucosylated	597:608	arg1	glycans					613:619	afucosylated Fc glycans	597:619	afucosylated Fc glycans	597:619	Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans.
33169014	4	47	theme	Fc	627:628	arg1	modification					630:641	This Fc modification	622:641	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs	622:697	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	1	48	from	illness	227:233	arg1	severities					206:215	severities	206:215	severities from mild illness to life-threatening pneumonia and multi-organ failure	206:287	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	1	48	from	illness	227:233	arg1	range					197:201	a range	195:201	a range of severities from mild illness to life-threatening pneumonia and multi-organ failure	195:287	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	3	49	with	IgG1	587:590	arg1	glycans					613:619	afucosylated Fc glycans	597:619	afucosylated Fc glycans	597:619	Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans.
33169014	4	50	theme	receptor	745:752	arg1	FcγRIIIa					754:761	the activating Fcγ receptor FcγRIIIa	726:761	the activating Fcγ receptor FcγRIIIa	726:761	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	4	51	theme	inflammatory	845:856	arg1	cytokines					858:866	inflammatory cytokines	845:866	inflammatory cytokines	845:866	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	2	52	theme	inflammatory	329:340	arg1	signature					342:350	an inflammatory signature	326:350	an inflammatory signature	326:350	Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi.
33169014	1	53	theme	severities	206:215	arg1	range					197:201	a range	195:201	a range of severities from mild illness to life-threatening pneumonia and multi-organ failure	195:287	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	3	54	theme	increased	563:571	arg1	likelihood					573:582	an increased likelihood	560:582	an increased likelihood of IgG1 with afucosylated Fc glycans	560:619	Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans.
33169014	1	55	theme	coronavirus	137:147	arg1	disease					149:155	coronavirus disease 2019 (COVID-19)	137:171	coronavirus disease 2019 (COVID-19)	137:171	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	3	56	theme	severe	495:500	arg1	COVID-19					502:509	severe COVID-19	495:509	severe COVID-19	495:509	Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans.
33169014	4	57	theme	syndrome	671:678	arg1	coronavirus					680:690	severe acute respiratory syndrome coronavirus 2	646:692	severe acute respiratory syndrome coronavirus 2 IgGs	646:697	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	4	58	theme	cytokines	858:866	arg1	production					831:840	production	831:840	production of inflammatory cytokines	831:866	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	4	59	theme	respiratory	659:669	arg1	coronavirus					680:690	severe acute respiratory syndrome coronavirus 2	646:692	severe acute respiratory syndrome coronavirus 2 IgGs	646:697	This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor.
33169014	5	60	theme	proinflammatory	1018:1032	arg1	IgG1					1076:1079	afucosylated IgG1	1063:1079	afucosylated IgG1	1063:1079	These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
33169014	5	60	theme	proinflammatory	1018:1032	arg1	structures					1041:1050	proinflammatory IgG Fc structures	1018:1050	proinflammatory IgG Fc structures	1018:1050	These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
33169014	1	61	theme	mild	222:225	arg1	illness					227:233	mild illness	222:233	mild illness	222:233	Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure.
33169014	0	62	from	structures	23:32	arg1	patients					37:44	patients	37:44	patients with severe COVID-19	37:65	Proinflammatory IgG Fc structures in patients with severe COVID-19.
33169014	0	63	theme	Fc	20:21	arg1	structures					23:32	Proinflammatory IgG Fc structures	0:32	Proinflammatory IgG Fc structures in patients with severe COVID-19	0:65	Proinflammatory IgG Fc structures in patients with severe COVID-19.
33169014	0	64	with	patients	37:44	arg1	COVID-19					58:65	severe COVID-19	51:65	severe COVID-19	51:65	Proinflammatory IgG Fc structures in patients with severe COVID-19.
33169014	3	65	theme	afucosylated	597:608	arg1	glycans					613:619	afucosylated Fc glycans	597:619	afucosylated Fc glycans	597:619	Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans.
32919005	3	0	theme	self-assembled	605:618	arg1	nanoparticles					620:632	self-assembled nanoparticles	605:632	self-assembled nanoparticles (116 nm in diameter)	605:653	mPPHP NPs formed self-assembled nanoparticles (116 nm in diameter) with a narrow size distribution; and showed a rapid release of PTX in the presence of hyaluronidase and esterase.
32919005	2	1	theme	poly	383:386	arg1	-poly					405:409	self-assembling methoxy poly (ethylene glycol)-poly	359:409	self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX)	359:496	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	2	1	theme	poly	383:386	arg1	lactide					412:418	lactide	412:418	lactide	412:418	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	1	2	theme	intracellular	275:287	arg1	release					294:300	slow intracellular drug release	270:300	slow intracellular drug release	270:300	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	0	3	theme	cancer	100:105	arg1	therapy					107:113	enhanced cancer therapy	91:113	enhanced cancer therapy	91:113	Multifunctional composite nanoparticles based on hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy.
32919005	4	4	theme	selected	846:853	arg1	cytotoxicity					855:866	selected cytotoxicity	846:866	selected cytotoxicity against A549 cells in vitro	846:894	mPPHP NPs exhibited enhanced internalization by cells via CD44 receptors and selected cytotoxicity against A549 cells in vitro.
32919005	2	5	theme	methoxy	375:381	arg1	-poly					405:409	self-assembling methoxy poly (ethylene glycol)-poly	359:409	self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX)	359:496	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	2	5	theme	methoxy	375:381	arg1	lactide					412:418	lactide	412:418	lactide	412:418	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	1	6	theme	drug	289:292	arg1	release					294:300	slow intracellular drug release	270:300	slow intracellular drug release	270:300	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	2	7	theme	mPPHP	528:532	arg1	nanoparticles					513:525	the composite nanoparticles	499:525	the composite nanoparticles (mPPHP NPs)	499:537	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	2	7	theme	mPPHP	528:532	arg1	NPs					534:536	mPPHP NPs	528:536	mPPHP NPs	528:536	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	5	8	theme	%	1117:1117	arg1	TIR					1106:1108	a TIR	1104:1108	a TIR of 75.9%	1104:1117	More importantly, compared with other PTX formulations, mPPHP NPs were demonstrated to present the reduced liver accumulation, excellent tumor-targeting ability and superior antitumor efficacy in vivo, with a TIR of 75.9%.
32919005	4	9	theme	A549	876:879	arg1	cells					881:885	A549 cells	876:885	A549 cells	876:885	mPPHP NPs exhibited enhanced internalization by cells via CD44 receptors and selected cytotoxicity against A549 cells in vitro.
32919005	2	10	theme	cancer	580:585	arg1	therapy					569:575	efficient therapy	559:575	efficient therapy of cancer	559:585	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	5	11	theme	mPPHP	953:957	arg1	NPs					959:961	mPPHP NPs	953:961	mPPHP NPs	953:961	More importantly, compared with other PTX formulations, mPPHP NPs were demonstrated to present the reduced liver accumulation, excellent tumor-targeting ability and superior antitumor efficacy in vivo, with a TIR of 75.9%.
32919005	4	12	theme	CD44	827:830	arg1	receptors					832:840	CD44 receptors	827:840	CD44 receptors	827:840	mPPHP NPs exhibited enhanced internalization by cells via CD44 receptors and selected cytotoxicity against A549 cells in vitro.
32919005	6	13	theme	promising	1188:1196	arg1	nano-carrier					1198:1209	a promising nano-carrier	1186:1209	a promising nano-carrier for improved therapeutic efficacy	1186:1243	The multifunctional composite nanoparticles could be developed as a promising nano-carrier for improved therapeutic efficacy.
32919005	6	13	theme	promising	1188:1196	arg1	nanoparticles					1150:1162	The multifunctional composite nanoparticles	1120:1162	The multifunctional composite nanoparticles	1120:1162	The multifunctional composite nanoparticles could be developed as a promising nano-carrier for improved therapeutic efficacy.
32919005	2	14	theme	composite	503:511	arg1	nanoparticles					513:525	the composite nanoparticles	499:525	the composite nanoparticles (mPPHP NPs)	499:537	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	2	14	theme	composite	503:511	arg1	NPs					534:536	mPPHP NPs	528:536	mPPHP NPs	528:536	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	1	15	theme	numerous	209:216	arg1	obstacles					218:226	numerous obstacles	209:226	numerous obstacles	209:226	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	1	15	theme	numerous	209:216	arg1	release					294:300	slow intracellular drug release	270:300	slow intracellular drug release	270:300	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	1	15	theme	numerous	209:216	arg1	capability					258:267	poor tumor targeting capability	237:267	poor tumor targeting capability	237:267	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	1	15	theme	numerous	209:216	arg1	accumulation					314:325	massive accumulation	306:325	massive accumulation in the liver	306:338	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	3	16	theme	rapid	701:705	arg1	release					707:713	a rapid release	699:713	a rapid release of PTX	699:720	mPPHP NPs formed self-assembled nanoparticles (116 nm in diameter) with a narrow size distribution; and showed a rapid release of PTX in the presence of hyaluronidase and esterase.
32919005	6	17	theme	composite	1140:1148	arg1	nano-carrier					1198:1209	a promising nano-carrier	1186:1209	a promising nano-carrier for improved therapeutic efficacy	1186:1243	The multifunctional composite nanoparticles could be developed as a promising nano-carrier for improved therapeutic efficacy.
32919005	6	17	theme	composite	1140:1148	arg1	nanoparticles					1150:1162	The multifunctional composite nanoparticles	1120:1162	The multifunctional composite nanoparticles	1120:1162	The multifunctional composite nanoparticles could be developed as a promising nano-carrier for improved therapeutic efficacy.
32919005	0	18	theme	Multifunctional	0:14	arg1	composite					16:24	Multifunctional composite	0:24	Multifunctional composite	0:24	Multifunctional composite nanoparticles based on hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy.
32919005	1	19	theme	massive	306:312	arg1	accumulation					314:325	massive accumulation	306:325	massive accumulation in the liver	306:338	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	1	20	from	accumulation	314:325	arg1	liver					334:338	the liver	330:338	the liver	330:338	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	3	21	theme	narrow	662:667	arg1	distribution					674:685	a narrow size distribution	660:685	a narrow size distribution	660:685	mPPHP NPs formed self-assembled nanoparticles (116 nm in diameter) with a narrow size distribution; and showed a rapid release of PTX in the presence of hyaluronidase and esterase.
32919005	2	22	theme	glycol	398:403	arg1	-poly					405:409	self-assembling methoxy poly (ethylene glycol)-poly	359:409	self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX)	359:496	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	2	22	theme	glycol	398:403	arg1	lactide					412:418	lactide	412:418	lactide	412:418	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	1	23	from	release	294:300	arg1	liver					334:338	the liver	330:338	the liver	330:338	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	1	24	theme	efficient	120:128	arg1	delivery					130:137	The efficient delivery	116:137	The efficient delivery of chemotherapeutic drugs to the tumor tissues	116:184	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	5	25	theme	reduced	996:1002	arg1	accumulation					1010:1021	the reduced liver accumulation	992:1021	the reduced liver accumulation	992:1021	More importantly, compared with other PTX formulations, mPPHP NPs were demonstrated to present the reduced liver accumulation, excellent tumor-targeting ability and superior antitumor efficacy in vivo, with a TIR of 75.9%.
32919005	5	26	theme	excellent	1024:1032	arg1	ability					1050:1056	excellent tumor-targeting ability	1024:1056	excellent tumor-targeting ability	1024:1056	More importantly, compared with other PTX formulations, mPPHP NPs were demonstrated to present the reduced liver accumulation, excellent tumor-targeting ability and superior antitumor efficacy in vivo, with a TIR of 75.9%.
32919005	3	27	theme	PTX	718:720	arg1	release					707:713	a rapid release	699:713	a rapid release of PTX	699:720	mPPHP NPs formed self-assembled nanoparticles (116 nm in diameter) with a narrow size distribution; and showed a rapid release of PTX in the presence of hyaluronidase and esterase.
32919005	5	28	theme	other	929:933	arg1	formulations					939:950	other PTX formulations	929:950	other PTX formulations	929:950	More importantly, compared with other PTX formulations, mPPHP NPs were demonstrated to present the reduced liver accumulation, excellent tumor-targeting ability and superior antitumor efficacy in vivo, with a TIR of 75.9%.
32919005	5	29	theme	superior	1062:1069	arg1	efficacy					1081:1088	superior antitumor efficacy	1062:1088	superior antitumor efficacy	1062:1088	More importantly, compared with other PTX formulations, mPPHP NPs were demonstrated to present the reduced liver accumulation, excellent tumor-targeting ability and superior antitumor efficacy in vivo, with a TIR of 75.9%.
32919005	6	30	theme	multifunctional	1124:1138	arg1	nano-carrier					1198:1209	a promising nano-carrier	1186:1209	a promising nano-carrier for improved therapeutic efficacy	1186:1243	The multifunctional composite nanoparticles could be developed as a promising nano-carrier for improved therapeutic efficacy.
32919005	6	30	theme	multifunctional	1124:1138	arg1	nanoparticles					1150:1162	The multifunctional composite nanoparticles	1120:1162	The multifunctional composite nanoparticles	1120:1162	The multifunctional composite nanoparticles could be developed as a promising nano-carrier for improved therapeutic efficacy.
32919005	0	31	theme	hyaluronic	49:58	arg1	conjugates					76:85	hyaluronic acid-paclitaxel conjugates	49:85	hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy	49:113	Multifunctional composite nanoparticles based on hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy.
32919005	3	32	dep	nanoparticles	620:632	arg1	116 nm					635:640	116 nm	635:640	116 nm in diameter	635:652	mPPHP NPs formed self-assembled nanoparticles (116 nm in diameter) with a narrow size distribution; and showed a rapid release of PTX in the presence of hyaluronidase and esterase.
32919005	3	33	theme	mPPHP	588:592	arg1	NPs					594:596	mPPHP NPs	588:596	mPPHP NPs	588:596	mPPHP NPs formed self-assembled nanoparticles (116 nm in diameter) with a narrow size distribution; and showed a rapid release of PTX in the presence of hyaluronidase and esterase.
32919005	1	34	theme	poor	237:240	arg1	capability					258:267	poor tumor targeting capability	237:267	poor tumor targeting capability	237:267	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	4	35	theme	enhanced	789:796	arg1	internalization					798:812	enhanced internalization	789:812	enhanced internalization by cells via CD44 receptors	789:840	mPPHP NPs exhibited enhanced internalization by cells via CD44 receptors and selected cytotoxicity against A549 cells in vitro.
32919005	1	36	theme	tumor	242:246	arg1	capability					258:267	poor tumor targeting capability	237:267	poor tumor targeting capability	237:267	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	2	37	theme	acid-paclitaxel	463:477	arg1	HA-PTX					490:495	HA-PTX	490:495	HA-PTX	490:495	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	2	37	theme	acid-paclitaxel	463:477	arg1	conjugate					479:487	hyaluronic acid-paclitaxel conjugate	452:487	hyaluronic acid-paclitaxel conjugate (HA-PTX)	452:496	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	3	38	theme	esterase	759:766	arg1	presence					729:736	the presence	725:736	the presence of hyaluronidase and esterase	725:766	mPPHP NPs formed self-assembled nanoparticles (116 nm in diameter) with a narrow size distribution; and showed a rapid release of PTX in the presence of hyaluronidase and esterase.
32919005	6	39	theme	improved	1215:1222	arg1	efficacy					1236:1243	improved therapeutic efficacy	1215:1243	improved therapeutic efficacy	1215:1243	The multifunctional composite nanoparticles could be developed as a promising nano-carrier for improved therapeutic efficacy.
32919005	2	40	theme	self-assembling	359:373	arg1	-poly					405:409	self-assembling methoxy poly (ethylene glycol)-poly	359:409	self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX)	359:496	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	2	40	theme	self-assembling	359:373	arg1	lactide					412:418	lactide	412:418	lactide	412:418	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	0	41	theme	acid-paclitaxel	60:74	arg1	conjugates					76:85	hyaluronic acid-paclitaxel conjugates	49:85	hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy	49:113	Multifunctional composite nanoparticles based on hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy.
32919005	6	42	theme	therapeutic	1224:1234	arg1	efficacy					1236:1243	improved therapeutic efficacy	1215:1243	improved therapeutic efficacy	1215:1243	The multifunctional composite nanoparticles could be developed as a promising nano-carrier for improved therapeutic efficacy.
32919005	2	43	theme	hyaluronic	452:461	arg1	HA-PTX					490:495	HA-PTX	490:495	HA-PTX	490:495	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	2	43	theme	hyaluronic	452:461	arg1	conjugate					479:487	hyaluronic acid-paclitaxel conjugate	452:487	hyaluronic acid-paclitaxel conjugate (HA-PTX)	452:496	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	5	44	theme	tumor-targeting	1034:1048	arg1	ability					1050:1056	excellent tumor-targeting ability	1024:1056	excellent tumor-targeting ability	1024:1056	More importantly, compared with other PTX formulations, mPPHP NPs were demonstrated to present the reduced liver accumulation, excellent tumor-targeting ability and superior antitumor efficacy in vivo, with a TIR of 75.9%.
32919005	1	45	theme	chemotherapeutic	142:157	arg1	drugs					159:163	chemotherapeutic drugs	142:163	chemotherapeutic drugs	142:163	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	3	46	from	116 nm	635:640	arg1	diameter					645:652	diameter	645:652	diameter	645:652	mPPHP NPs formed self-assembled nanoparticles (116 nm in diameter) with a narrow size distribution; and showed a rapid release of PTX in the presence of hyaluronidase and esterase.
32919005	3	47	theme	hyaluronidase	741:753	arg1	presence					729:736	the presence	725:736	the presence of hyaluronidase and esterase	725:766	mPPHP NPs formed self-assembled nanoparticles (116 nm in diameter) with a narrow size distribution; and showed a rapid release of PTX in the presence of hyaluronidase and esterase.
32919005	2	48	theme	efficient	559:567	arg1	therapy					569:575	efficient therapy	559:575	efficient therapy of cancer	559:585	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	3	49	theme	size	669:672	arg1	distribution					674:685	a narrow size distribution	660:685	a narrow size distribution	660:685	mPPHP NPs formed self-assembled nanoparticles (116 nm in diameter) with a narrow size distribution; and showed a rapid release of PTX in the presence of hyaluronidase and esterase.
32919005	4	50	theme	mPPHP	769:773	arg1	NPs					775:777	mPPHP NPs	769:777	mPPHP NPs	769:777	mPPHP NPs exhibited enhanced internalization by cells via CD44 receptors and selected cytotoxicity against A549 cells in vitro.
32919005	5	51	theme	liver	1004:1008	arg1	accumulation					1010:1021	the reduced liver accumulation	992:1021	the reduced liver accumulation	992:1021	More importantly, compared with other PTX formulations, mPPHP NPs were demonstrated to present the reduced liver accumulation, excellent tumor-targeting ability and superior antitumor efficacy in vivo, with a TIR of 75.9%.
32919005	1	52	theme	drugs	159:163	arg1	delivery					130:137	The efficient delivery	116:137	The efficient delivery of chemotherapeutic drugs to the tumor tissues	116:184	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	5	53	theme	PTX	935:937	arg1	formulations					939:950	other PTX formulations	929:950	other PTX formulations	929:950	More importantly, compared with other PTX formulations, mPPHP NPs were demonstrated to present the reduced liver accumulation, excellent tumor-targeting ability and superior antitumor efficacy in vivo, with a TIR of 75.9%.
32919005	1	54	theme	targeting	248:256	arg1	capability					258:267	poor tumor targeting capability	237:267	poor tumor targeting capability	237:267	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	1	55	from	capability	258:267	arg1	liver					334:338	the liver	330:338	the liver	330:338	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	0	56	dep	nanoparticles	26:38	arg1	based					40:44	based	40:44	nanoparticles based on hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy	26:113	Multifunctional composite nanoparticles based on hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy.
32919005	5	57	theme	antitumor	1071:1079	arg1	efficacy					1081:1088	superior antitumor efficacy	1062:1088	superior antitumor efficacy	1062:1088	More importantly, compared with other PTX formulations, mPPHP NPs were demonstrated to present the reduced liver accumulation, excellent tumor-targeting ability and superior antitumor efficacy in vivo, with a TIR of 75.9%.
32919005	0	58	theme	enhanced	91:98	arg1	therapy					107:113	enhanced cancer therapy	91:113	enhanced cancer therapy	91:113	Multifunctional composite nanoparticles based on hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy.
32919005	2	59	theme	ethylene	389:396	arg1	-poly					405:409	self-assembling methoxy poly (ethylene glycol)-poly	359:409	self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX)	359:496	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	2	59	theme	ethylene	389:396	arg1	lactide					412:418	lactide	412:418	lactide	412:418	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	2	60	dep	-poly	405:409	arg1	block					421:425	block	421:425	block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX)	421:496	In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer.
32919005	1	61	theme	tumor	172:176	arg1	tissues					178:184	the tumor tissues	168:184	the tumor tissues	168:184	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32919005	1	62	theme	slow	270:273	arg1	release					294:300	slow intracellular drug release	270:300	slow intracellular drug release	270:300	The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver.
32563918	0	0	theme	antibacterial	96:108	arg1	efficacy					110:117	antibacterial efficacy	96:117	antibacterial efficacy	96:117	Alginate-based composite microspheres coated by berberine simultaneously improve hemostatic and antibacterial efficacy.
32563918	3	1	theme	polysaccharide	684:697	arg1	microspheres					699:710	Composite polysaccharide microspheres	674:710	Composite polysaccharide microspheres without berberine	674:728	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	2	theme	synergistic	998:1008	arg1	aggregation					941:951	aggregation	941:951	aggregation	941:951	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	2	theme	synergistic	998:1008	arg1	effects					1010:1016	synergistic effects	998:1016	synergistic effects	998:1016	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	2	theme	synergistic	998:1008	arg1	adhesion					928:935	adhesion	928:935	adhesion	928:935	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	1	3	theme	stored	180:185	arg1	hemostats					202:210	effective, biocompatible, easily stored and affordable hemostats	147:210	effective, biocompatible, easily stored and affordable hemostats for controlling bleeding and preventing infection in prehospital trauma	147:282	It is important to develop effective, biocompatible, easily stored and affordable hemostats for controlling bleeding and preventing infection in prehospital trauma.
32563918	3	4	theme	antibacterial	854:866	arg1	activity					868:875	inherent excellent antibacterial activity	835:875	inherent excellent antibacterial activity	835:875	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	2	5	dep	transform	553:561	arg1	infrared					563:570	infrared	563:570	transform infrared (FT-IR) spectroscopy	553:591	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	3	6	with	SCC-10B	772:778	arg1	berberine					800:808	proper content berberine	785:808	proper content berberine (7%)	785:813	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	6	with	SCC-10B	772:778	arg1	%					812:812	7%	811:812	7%	811:812	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	2	7	dep	Fourier	545:551	arg1	transform					553:561	transform	553:561	transform infrared (FT-IR) spectroscopy	553:591	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	4	8	link	cross-linked	1074:1085	arg1	network					1087:1093	the cross-linked network	1070:1093	the cross-linked network	1070:1093	More importantly, through inserting berberine into the cross-linked network, biodegradability and biocompatibility of SCC-10B were also improved.
32563918	3	9	theme	hemostatic	896:905	arg1	effect					907:912	hemostatic effect	896:912	hemostatic effect	896:912	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	2	10	theme	particle	523:530	arg1	analyzer					532:539	particle analyzer	523:539	particle analyzer	523:539	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	4	11	theme	SCC-10B	1137:1143	arg1	biocompatibility					1117:1132	biocompatibility	1117:1132	biocompatibility	1117:1132	More importantly, through inserting berberine into the cross-linked network, biodegradability and biocompatibility of SCC-10B were also improved.
32563918	4	11	theme	SCC-10B	1137:1143	arg1	biodegradability					1096:1111	biodegradability	1096:1111	biodegradability	1096:1111	More importantly, through inserting berberine into the cross-linked network, biodegradability and biocompatibility of SCC-10B were also improved.
32563918	2	12	dep	berberine	396:404	arg1	SCC-5B					415:420	SCC-5B	415:420	SCC-5B	415:420	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	2	12	dep	berberine	396:404	arg1	SCC-1B					407:412	SCC-1B	407:412	SCC-1B	407:412	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	2	12	dep	berberine	396:404	arg1	SCC-10B					426:432	SCC-10B	426:432	SCC-10B	426:432	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	1	13	theme	affordable	191:200	arg1	hemostats					202:210	effective, biocompatible, easily stored and affordable hemostats	147:210	effective, biocompatible, easily stored and affordable hemostats for controlling bleeding and preventing infection in prehospital trauma	147:282	It is important to develop effective, biocompatible, easily stored and affordable hemostats for controlling bleeding and preventing infection in prehospital trauma.
32563918	0	14	theme	composite	15:23	arg1	microspheres					25:36	Alginate-based composite microspheres	0:36	Alginate-based composite microspheres coated by berberine	0:56	Alginate-based composite microspheres coated by berberine simultaneously improve hemostatic and antibacterial efficacy.
32563918	2	15	theme	composite	342:350	arg1	microspheres					352:363	alginate-based composite microspheres	327:363	alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B)	327:433	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	0	16	theme	Alginate-based	0:13	arg1	microspheres					25:36	Alginate-based composite microspheres	0:36	Alginate-based composite microspheres coated by berberine	0:56	Alginate-based composite microspheres coated by berberine simultaneously improve hemostatic and antibacterial efficacy.
32563918	2	17	theme	alginate-based	327:340	arg1	microspheres					352:363	alginate-based composite microspheres	327:363	alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B)	327:433	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	3	18	theme	Commercial	742:751	arg1	agent					764:768	Commercial hemostatic agent	742:768	Commercial hemostatic agent	742:768	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	18	theme	Commercial	742:751	arg1	SCC					669:671	SCC	669:671	SCC	669:671	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	19	theme	control	654:660	arg1	group					662:666	control group	654:666	control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent)	654:769	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	20	theme	hemostatic	753:762	arg1	agent					764:768	Commercial hemostatic agent	742:768	Commercial hemostatic agent	742:768	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	20	theme	hemostatic	753:762	arg1	SCC					669:671	SCC	669:671	SCC	669:671	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	5	21	from	candidate	1200:1208	arg1	trauma					1278:1283	prehospital trauma	1266:1283	prehospital trauma	1266:1283	Taken together, SCC-10B could be a candidate for emergency hemostatic and antibacterial treatment in prehospital trauma.
32563918	4	22	theme	cross-linked	1074:1085	arg1	network					1087:1093	the cross-linked network	1070:1093	the cross-linked network	1070:1093	More importantly, through inserting berberine into the cross-linked network, biodegradability and biocompatibility of SCC-10B were also improved.
32563918	3	23	theme	content	792:798	arg1	berberine					800:808	proper content berberine	785:808	proper content berberine (7%)	785:813	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	23	theme	content	792:798	arg1	%					812:812	7%	811:812	7%	811:812	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	24	theme	blood	956:960	arg1	cells					962:966	blood cells	956:966	blood cells	956:966	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	2	25	theme	electron	484:491	arg1	SEM					505:507	SEM	505:507	SEM	505:507	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	2	25	theme	electron	484:491	arg1	microscopy					493:502	scanning electron microscopy	475:502	scanning electron microscopy (SEM)	475:508	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	3	26	theme	proper	785:790	arg1	berberine					800:808	proper content berberine	785:808	proper content berberine (7%)	785:813	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	26	theme	proper	785:790	arg1	%					812:812	7%	811:812	7%	811:812	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	27	theme	cells	962:966	arg1	aggregation					941:951	aggregation	941:951	aggregation	941:951	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	27	theme	cells	962:966	arg1	effects					1010:1016	synergistic effects	998:1016	synergistic effects	998:1016	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	27	theme	cells	962:966	arg1	adhesion					928:935	adhesion	928:935	adhesion	928:935	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	2	28	theme	different	375:383	arg1	berberine					396:404	berberine	396:404	berberine (SCC-1B, SCC-5B and SCC-10B)	396:433	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	2	28	theme	different	375:383	arg1	amounts					385:391	different amounts	375:391	different amounts of berberine (SCC-1B, SCC-5B and SCC-10B)	375:433	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	2	29	theme	scanning	475:482	arg1	SEM					505:507	SEM	505:507	SEM	505:507	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	2	29	theme	scanning	475:482	arg1	microscopy					493:502	scanning electron microscopy	475:502	scanning electron microscopy (SEM)	475:508	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	3	30	theme	in	598:599	arg1	results					616:622	The in vitro and vivo results	594:622	The in vitro and vivo results	594:622	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	31	theme	inherent	835:842	arg1	activity					868:875	inherent excellent antibacterial activity	835:875	inherent excellent antibacterial activity	835:875	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	1	32	from	infection	252:260	arg1	trauma					277:282	prehospital trauma	265:282	prehospital trauma	265:282	It is important to develop effective, biocompatible, easily stored and affordable hemostats for controlling bleeding and preventing infection in prehospital trauma.
32563918	3	33	theme	Composite	674:682	arg1	microspheres					699:710	Composite polysaccharide microspheres	674:710	Composite polysaccharide microspheres without berberine	674:728	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	1	34	theme	effective	147:155	arg1	hemostats					202:210	effective, biocompatible, easily stored and affordable hemostats	147:210	effective, biocompatible, easily stored and affordable hemostats for controlling bleeding and preventing infection in prehospital trauma	147:282	It is important to develop effective, biocompatible, easily stored and affordable hemostats for controlling bleeding and preventing infection in prehospital trauma.
32563918	3	35	theme	excellent	844:852	arg1	activity					868:875	inherent excellent antibacterial activity	835:875	inherent excellent antibacterial activity	835:875	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	2	36	theme	FT-IR	573:577	arg1	spectroscopy					580:591	(FT-IR) spectroscopy	572:591	(FT-IR) spectroscopy	572:591	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	2	37	theme	microspheres	352:363	arg1	series					317:322	a series	315:322	a series	315:322	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	5	38	theme	antibacterial	1239:1251	arg1	treatment					1253:1261	emergency hemostatic and antibacterial treatment	1214:1261	treatment	1253:1261	Taken together, SCC-10B could be a candidate for emergency hemostatic and antibacterial treatment in prehospital trauma.
32563918	3	39	theme	vivo	611:614	arg1	results					616:622	The in vitro and vivo results	594:622	The in vitro and vivo results	594:622	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	1	40	theme	biocompatible	158:170	arg1	hemostats					202:210	effective, biocompatible, easily stored and affordable hemostats	147:210	effective, biocompatible, easily stored and affordable hemostats for controlling bleeding and preventing infection in prehospital trauma	147:282	It is important to develop effective, biocompatible, easily stored and affordable hemostats for controlling bleeding and preventing infection in prehospital trauma.
32563918	3	41	dep	in	598:599	arg1	vitro					601:605	vitro	601:605	vitro	601:605	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	1	42	theme	prehospital	265:275	arg1	trauma					277:282	prehospital trauma	265:282	prehospital trauma	265:282	It is important to develop effective, biocompatible, easily stored and affordable hemostats for controlling bleeding and preventing infection in prehospital trauma.
32563918	2	43	theme	berberine	396:404	arg1	berberine					396:404	berberine	396:404	berberine (SCC-1B, SCC-5B and SCC-10B)	396:433	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	2	43	theme	berberine	396:404	arg1	amounts					385:391	different amounts	375:391	different amounts of berberine (SCC-1B, SCC-5B and SCC-10B)	375:433	In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy.
32563918	5	44	theme	prehospital	1266:1276	arg1	trauma					1278:1283	prehospital trauma	1266:1283	prehospital trauma	1266:1283	Taken together, SCC-10B could be a candidate for emergency hemostatic and antibacterial treatment in prehospital trauma.
32563918	3	45	dep	group	662:666	arg1	agent					764:768	Commercial hemostatic agent	742:768	Commercial hemostatic agent	742:768	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	45	dep	group	662:666	arg1	SCC					669:671	SCC	669:671	SCC	669:671	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	45	dep	group	662:666	arg1	CMPHP					735:739	CMPHP	735:739	CMPHP	735:739	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32563918	3	45	dep	group	662:666	arg1	microspheres					699:710	Composite polysaccharide microspheres	674:710	Composite polysaccharide microspheres without berberine	674:728	The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects.
32070532	5	0	theme	method	887:892	arg1	applicability					866:878	the general applicability	854:878	the general applicability of the method	854:892	The same method was also applied to analyze immobilize penicillin G acylase (PGA) to further investigate the general applicability of the method.
32070532	1	1	theme	carboxymethyl	174:186	arg1	IL-MCMC					213:219	IL-MCMC	213:219	IL-MCMC	213:219	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	1	1	theme	carboxymethyl	174:186	arg1	nanoparticles					198:210	ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles	142:210	ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC)	142:220	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	1	1	theme	carboxymethyl	174:186	arg1	supports					248:255	supports	248:255	supports	248:255	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	1	2	theme	cellulose	188:196	arg1	IL-MCMC					213:219	IL-MCMC	213:219	IL-MCMC	213:219	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	1	2	theme	cellulose	188:196	arg1	nanoparticles					198:210	ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles	142:210	ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC)	142:220	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	1	2	theme	cellulose	188:196	arg1	supports					248:255	supports	248:255	supports	248:255	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	7	3	from	immobilization	1071:1084	arg1	application					1100:1110	industrial application	1089:1110	industrial application	1089:1110	The developed composites may be utilized as excellent supports for enzyme immobilization in industrial application.
32070532	0	4	theme	performance	115:125	arg1	Improvement					90:100	Improvement	90:100	Improvement of catalytic performance	90:125	Ionic liquids-modified cellulose coated magnetic nanoparticles for enzyme immobilization: Improvement of catalytic performance.
32070532	2	5	theme	lipase	321:326	arg1	PPL-IL-MCMC					328:338	immobilized lipase PPL-IL-MCMC	309:338	immobilized lipase PPL-IL-MCMC	309:338	The specific activity of immobilized lipase PPL-IL-MCMC was 1.43 and 2.81 folds higher than that of free PPL and PPL-MCMC, respectively.
32070532	3	6	theme	lipase	582:587	arg1	lid-opening					567:577	the lid-opening	563:577	the lid-opening of lipase	563:587	Water contact angle analysis indicated that the introduction of ionic liquids increased the hydrophobicity of supports, which in tune induced the lid-opening of lipase, allowing its active sites to become more accessible.
32070532	0	7	theme	catalytic	105:113	arg1	performance					115:125	catalytic performance	105:125	catalytic performance	105:125	Ionic liquids-modified cellulose coated magnetic nanoparticles for enzyme immobilization: Improvement of catalytic performance.
32070532	2	8	theme	immobilized	309:319	arg1	PPL-IL-MCMC					328:338	immobilized lipase PPL-IL-MCMC	309:338	immobilized lipase PPL-IL-MCMC	309:338	The specific activity of immobilized lipase PPL-IL-MCMC was 1.43 and 2.81 folds higher than that of free PPL and PPL-MCMC, respectively.
32070532	2	9	dep	1.43	344:347	arg1	folds					358:362	folds	358:362	folds higher than that of free PPL and PPL-MCMC, respectively	358:418	The specific activity of immobilized lipase PPL-IL-MCMC was 1.43 and 2.81 folds higher than that of free PPL and PPL-MCMC, respectively.
32070532	5	10	theme	same	753:756	arg1	method					758:763	The same method	749:763	The same method	749:763	The same method was also applied to analyze immobilize penicillin G acylase (PGA) to further investigate the general applicability of the method.
32070532	5	11	theme	general	858:864	arg1	applicability					866:878	the general applicability	854:878	the general applicability of the method	854:892	The same method was also applied to analyze immobilize penicillin G acylase (PGA) to further investigate the general applicability of the method.
32070532	5	12	theme	G	815:815	arg1	PGA					826:828	PGA	826:828	PGA	826:828	The same method was also applied to analyze immobilize penicillin G acylase (PGA) to further investigate the general applicability of the method.
32070532	5	12	theme	G	815:815	arg1	acylase					817:823	penicillin G acylase	804:823	penicillin G acylase (PGA)	804:829	The same method was also applied to analyze immobilize penicillin G acylase (PGA) to further investigate the general applicability of the method.
32070532	0	13	theme	liquids-modified	6:21	arg1	cellulose					23:31	Ionic liquids-modified cellulose	0:31	Ionic liquids-modified cellulose	0:31	Ionic liquids-modified cellulose coated magnetic nanoparticles for enzyme immobilization: Improvement of catalytic performance.
32070532	0	14	theme	Ionic	0:4	arg1	cellulose					23:31	Ionic liquids-modified cellulose	0:31	Ionic liquids-modified cellulose	0:31	Ionic liquids-modified cellulose coated magnetic nanoparticles for enzyme immobilization: Improvement of catalytic performance.
32070532	6	15	theme	reported	982:989	arg1	PGAs					991:994	many other reported PGAs	971:994	many other reported PGAs	971:994	The results showed that the immobilized PGA exhibited higher stability than many other reported PGAs.
32070532	2	16	theme	free	384:387	arg1	PPL					389:391	free PPL	384:391	free PPL	384:391	The specific activity of immobilized lipase PPL-IL-MCMC was 1.43 and 2.81 folds higher than that of free PPL and PPL-MCMC, respectively.
32070532	7	17	dep	excellent	1041:1049	arg1	supports					1051:1058	supports	1051:1058	supports	1051:1058	The developed composites may be utilized as excellent supports for enzyme immobilization in industrial application.
32070532	3	18	theme	ionic	485:489	arg1	liquids					491:497	ionic liquids	485:497	ionic liquids	485:497	Water contact angle analysis indicated that the introduction of ionic liquids increased the hydrophobicity of supports, which in tune induced the lid-opening of lipase, allowing its active sites to become more accessible.
32070532	6	19	theme	many	971:974	arg1	PGAs					991:994	many other reported PGAs	971:994	many other reported PGAs	971:994	The results showed that the immobilized PGA exhibited higher stability than many other reported PGAs.
32070532	7	20	theme	industrial	1089:1098	arg1	application					1100:1110	industrial application	1089:1110	industrial application	1089:1110	The developed composites may be utilized as excellent supports for enzyme immobilization in industrial application.
32070532	2	21	theme	PPL-IL-MCMC	328:338	arg1	activity					297:304	The specific activity	284:304	The specific activity of immobilized lipase PPL-IL-MCMC	284:338	The specific activity of immobilized lipase PPL-IL-MCMC was 1.43 and 2.81 folds higher than that of free PPL and PPL-MCMC, respectively.
32070532	2	21	theme	PPL-IL-MCMC	328:338	arg1	1.43					344:347	1.43	344:347	1.43	344:347	The specific activity of immobilized lipase PPL-IL-MCMC was 1.43 and 2.81 folds higher than that of free PPL and PPL-MCMC, respectively.
32070532	3	22	theme	liquids	491:497	arg1	introduction					469:480	the introduction	465:480	the introduction of ionic liquids	465:497	Water contact angle analysis indicated that the introduction of ionic liquids increased the hydrophobicity of supports, which in tune induced the lid-opening of lipase, allowing its active sites to become more accessible.
32070532	3	23	theme	contact	427:433	arg1	analysis					441:448	Water contact angle analysis	421:448	Water contact angle analysis	421:448	Water contact angle analysis indicated that the introduction of ionic liquids increased the hydrophobicity of supports, which in tune induced the lid-opening of lipase, allowing its active sites to become more accessible.
32070532	7	24	theme	enzyme	1064:1069	arg1	immobilization					1071:1084	enzyme immobilization	1064:1084	enzyme immobilization in industrial application	1064:1110	The developed composites may be utilized as excellent supports for enzyme immobilization in industrial application.
32070532	1	25	used	used	240:243	arg2	nanoparticles					198:210	ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles	142:210	ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC)	142:220	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	1	25	used	used	240:243	arg2	supports					248:255	supports	248:255	supports	248:255	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	1	25	used	used	240:243	arg2	IL-MCMC					213:219	IL-MCMC	213:219	IL-MCMC	213:219	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	0	26	theme	magnetic	40:47	arg1	nanoparticles					49:61	magnetic nanoparticles	40:61	magnetic nanoparticles for enzyme immobilization	40:87	Ionic liquids-modified cellulose coated magnetic nanoparticles for enzyme immobilization: Improvement of catalytic performance.
32070532	3	27	theme	angle	435:439	arg1	analysis					441:448	Water contact angle analysis	421:448	Water contact angle analysis	421:448	Water contact angle analysis indicated that the introduction of ionic liquids increased the hydrophobicity of supports, which in tune induced the lid-opening of lipase, allowing its active sites to become more accessible.
32070532	0	28	theme	enzyme	67:72	arg1	immobilization					74:87	enzyme immobilization	67:87	enzyme immobilization	67:87	Ionic liquids-modified cellulose coated magnetic nanoparticles for enzyme immobilization: Improvement of catalytic performance.
32070532	3	29	theme	supports	531:538	arg1	hydrophobicity					513:526	the hydrophobicity	509:526	the hydrophobicity of supports, which in tune induced the lid-opening of lipase	509:587	Water contact angle analysis indicated that the introduction of ionic liquids increased the hydrophobicity of supports, which in tune induced the lid-opening of lipase, allowing its active sites to become more accessible.
32070532	6	30	theme	other	976:980	arg1	PGAs					991:994	many other reported PGAs	971:994	many other reported PGAs	971:994	The results showed that the immobilized PGA exhibited higher stability than many other reported PGAs.
32070532	3	31	theme	Water	421:425	arg1	analysis					441:448	Water contact angle analysis	421:448	Water contact angle analysis	421:448	Water contact angle analysis indicated that the introduction of ionic liquids increased the hydrophobicity of supports, which in tune induced the lid-opening of lipase, allowing its active sites to become more accessible.
32070532	3	32	theme	active	603:608	arg1	sites					610:614	its active sites	599:614	its active sites	599:614	Water contact angle analysis indicated that the introduction of ionic liquids increased the hydrophobicity of supports, which in tune induced the lid-opening of lipase, allowing its active sites to become more accessible.
32070532	2	33	theme	specific	288:295	arg1	activity					297:304	The specific activity	284:304	The specific activity of immobilized lipase PPL-IL-MCMC	284:338	The specific activity of immobilized lipase PPL-IL-MCMC was 1.43 and 2.81 folds higher than that of free PPL and PPL-MCMC, respectively.
32070532	2	33	theme	specific	288:295	arg1	1.43					344:347	1.43	344:347	1.43	344:347	The specific activity of immobilized lipase PPL-IL-MCMC was 1.43 and 2.81 folds higher than that of free PPL and PPL-MCMC, respectively.
32070532	4	34	dep	the	713:715	arg1	supports					726:733	supports	726:733	supports	726:733	In addition, the affinity between lipase and substrate immobilized on the prepared supports was enhanced.
32070532	1	35	theme	ionic	142:146	arg1	IL-MCMC					213:219	IL-MCMC	213:219	IL-MCMC	213:219	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	1	35	theme	ionic	142:146	arg1	nanoparticles					198:210	ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles	142:210	ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC)	142:220	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	1	35	theme	ionic	142:146	arg1	supports					248:255	supports	248:255	supports	248:255	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	7	36	used	utilized	1029:1036	arg2	composites					1011:1020	The developed composites	997:1020	The developed composites	997:1020	The developed composites may be utilized as excellent supports for enzyme immobilization in industrial application.
32070532	7	36	used	utilized	1029:1036	arg2	excellent					1041:1049	excellent	1041:1049	excellent	1041:1049	The developed composites may be utilized as excellent supports for enzyme immobilization in industrial application.
32070532	7	37	theme	developed	1001:1009	arg1	excellent					1041:1049	excellent	1041:1049	excellent	1041:1049	The developed composites may be utilized as excellent supports for enzyme immobilization in industrial application.
32070532	7	37	theme	developed	1001:1009	arg1	composites					1011:1020	The developed composites	997:1020	The developed composites	997:1020	The developed composites may be utilized as excellent supports for enzyme immobilization in industrial application.
32070532	1	38	theme	liquids-modified	148:163	arg1	IL-MCMC					213:219	IL-MCMC	213:219	IL-MCMC	213:219	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	1	38	theme	liquids-modified	148:163	arg1	nanoparticles					198:210	ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles	142:210	ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC)	142:220	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	1	38	theme	liquids-modified	148:163	arg1	supports					248:255	supports	248:255	supports	248:255	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	5	39	theme	penicillin	804:813	arg1	PGA					826:828	PGA	826:828	PGA	826:828	The same method was also applied to analyze immobilize penicillin G acylase (PGA) to further investigate the general applicability of the method.
32070532	5	39	theme	penicillin	804:813	arg1	acylase					817:823	penicillin G acylase	804:823	penicillin G acylase (PGA)	804:829	The same method was also applied to analyze immobilize penicillin G acylase (PGA) to further investigate the general applicability of the method.
32070532	6	40	theme	immobilized	923:933	arg1	PGA					935:937	the immobilized PGA	919:937	the immobilized PGA	919:937	The results showed that the immobilized PGA exhibited higher stability than many other reported PGAs.
32070532	1	41	theme	magnetic	165:172	arg1	IL-MCMC					213:219	IL-MCMC	213:219	IL-MCMC	213:219	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	1	41	theme	magnetic	165:172	arg1	nanoparticles					198:210	ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles	142:210	ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC)	142:220	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	1	41	theme	magnetic	165:172	arg1	supports					248:255	supports	248:255	supports	248:255	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
32070532	6	42	theme	higher	949:954	arg1	stability					956:964	higher stability	949:964	higher stability	949:964	The results showed that the immobilized PGA exhibited higher stability than many other reported PGAs.
32070532	1	43	theme	enzyme	261:266	arg1	immobilization					268:281	enzyme immobilization	261:281	enzyme immobilization	261:281	In this work, ionic liquids-modified magnetic carboxymethyl cellulose nanoparticles (IL-MCMC) were prepared and used as supports for enzyme immobilization.
33657015	11	0	dep	design	1347:1352	arg1	the					1343:1345	the	1343:1345	the	1343:1345	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	4	1	theme	collagen-chitosan	568:584	arg1	hydrogels					586:594	tube-like collagen-chitosan hydrogels	558:594	tube-like collagen-chitosan hydrogels	558:594	In this study, electro-deposition was employed to swiftly fabricate tube-like collagen-chitosan hydrogels in a mild environment.
33657015	8	2	theme	initial	1015:1021	arg1	ratio					1041:1045	the initial collagen:chitosan ratio	1011:1045	the initial collagen:chitosan ratio	1011:1045	Collagen was distributed homogeneously and its content was related to the initial collagen:chitosan ratio.
33657015	9	3	theme	tension	1052:1058	arg1	resistance					1060:1069	The tension resistance	1048:1069	The tension resistance of the composite gels	1048:1091	The tension resistance of the composite gels and the thermal stability of collagen in the composites were obviously enhanced by the chitosan doping.
33657015	9	4	from	stability	1109:1117	arg1	composites					1138:1147	the composites	1134:1147	the composites	1134:1147	The tension resistance of the composite gels and the thermal stability of collagen in the composites were obviously enhanced by the chitosan doping.
33657015	7	5	theme	collagen	834:841	arg1	content					823:829	content	823:829	content	823:829	The distribution and content of collagen in the hydrogels was further measured by hematoxylin-eosin staining and hydroxyproline titration.
33657015	7	5	theme	collagen	834:841	arg1	distribution					806:817	distribution	806:817	distribution	806:817	The distribution and content of collagen in the hydrogels was further measured by hematoxylin-eosin staining and hydroxyproline titration.
33657015	2	6	theme	biomedical	322:331	arg1	applications					333:344	biomedical applications	322:344	biomedical applications	322:344	Collagen, a functional protein with excellent biocompatibility and biosafety, is a promising candidate for tissue engineering and biomedical applications.
33657015	9	7	theme	chitosan	1180:1187	arg1	doping					1189:1194	the chitosan doping	1176:1194	the chitosan doping	1176:1194	The tension resistance of the composite gels and the thermal stability of collagen in the composites were obviously enhanced by the chitosan doping.
33657015	3	8	theme	biomaterials	403:414	arg1	electro-deposition					381:398	electro-deposition	381:398	electro-deposition of biomaterials using collagen without electrically or magnetically active nanoparticles	381:487	However, there are few reports on electro-deposition of biomaterials using collagen without electrically or magnetically active nanoparticles.
33657015	0	9	theme	Electro-deposition	0:17	arg1	synthesis					19:27	Electro-deposition synthesis	0:27	Electro-deposition synthesis of tube-like collagen-chitosan hydrogels and their biological performance	0:101	Electro-deposition synthesis of tube-like collagen-chitosan hydrogels and their biological performance.
33657015	5	10	theme	hydrogels	716:724	arg1	ingredients					687:697	the ingredients	683:697	the ingredients of the tube-like hydrogels	683:724	Fourier transform infrared spectroscopy was employed to analyze the ingredients of the tube-like hydrogels.
33657015	5	11	theme	tube-like	706:714	arg1	hydrogels					716:724	the tube-like hydrogels	702:724	the tube-like hydrogels	702:724	Fourier transform infrared spectroscopy was employed to analyze the ingredients of the tube-like hydrogels.
33657015	11	12	theme	collagen-based	1559:1572	arg1	materials					1574:1582	collagen-based materials	1559:1582	collagen-based materials	1559:1582	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	7	13	from	distribution	806:817	arg1	hydrogels					850:858	the hydrogels	846:858	the hydrogels	846:858	The distribution and content of collagen in the hydrogels was further measured by hematoxylin-eosin staining and hydroxyproline titration.
33657015	4	14	theme	tube-like	558:566	arg1	hydrogels					586:594	tube-like collagen-chitosan hydrogels	558:594	tube-like collagen-chitosan hydrogels	558:594	In this study, electro-deposition was employed to swiftly fabricate tube-like collagen-chitosan hydrogels in a mild environment.
33657015	0	15	theme	hydrogels	60:68	arg1	synthesis					19:27	Electro-deposition synthesis	0:27	Electro-deposition synthesis of tube-like collagen-chitosan hydrogels and their biological performance	0:101	Electro-deposition synthesis of tube-like collagen-chitosan hydrogels and their biological performance.
33657015	2	16	theme	tissue	299:304	arg1	engineering					306:316	tissue engineering	299:316	tissue engineering	299:316	Collagen, a functional protein with excellent biocompatibility and biosafety, is a promising candidate for tissue engineering and biomedical applications.
33657015	5	17	dep	transform	627:635	arg1	infrared					637:644	infrared	637:644	transform infrared spectroscopy	627:657	Fourier transform infrared spectroscopy was employed to analyze the ingredients of the tube-like hydrogels.
33657015	9	18	theme	gels	1088:1091	arg1	stability					1109:1117	the thermal stability	1097:1117	the thermal stability of collagen	1097:1129	The tension resistance of the composite gels and the thermal stability of collagen in the composites were obviously enhanced by the chitosan doping.
33657015	9	18	theme	gels	1088:1091	arg1	resistance					1060:1069	The tension resistance	1048:1069	The tension resistance of the composite gels	1048:1091	The tension resistance of the composite gels and the thermal stability of collagen in the composites were obviously enhanced by the chitosan doping.
33657015	11	19	theme	materials	1574:1582	arg1	stability					1509:1517	the stability	1505:1517	the stability of collagen	1505:1529	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	11	19	theme	materials	1574:1582	arg1	strength					1547:1554	the tensile strength	1535:1554	the tensile strength of collagen-based materials	1535:1582	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	0	20	theme	performance	91:101	arg1	synthesis					19:27	Electro-deposition synthesis	0:27	Electro-deposition synthesis of tube-like collagen-chitosan hydrogels and their biological performance	0:101	Electro-deposition synthesis of tube-like collagen-chitosan hydrogels and their biological performance.
33657015	11	21	theme	convenient	1320:1329	arg1	approach					1331:1338	a convenient approach	1318:1338	a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials	1318:1582	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	3	22	theme	electrically	439:450	arg1	nanoparticles					475:487	electrically or magnetically active nanoparticles	439:487	electrically or magnetically active nanoparticles	439:487	However, there are few reports on electro-deposition of biomaterials using collagen without electrically or magnetically active nanoparticles.
33657015	7	23	theme	hydroxyproline	915:928	arg1	titration					930:938	hydroxyproline titration	915:938	hydroxyproline titration	915:938	The distribution and content of collagen in the hydrogels was further measured by hematoxylin-eosin staining and hydroxyproline titration.
33657015	6	24	contain	contained	764:772	arg2	collagen					779:786	collagen	779:786	collagen	779:786	The result showed that the hydrogels contained both collagen and chitosan.
33657015	6	24	contain	contained	764:772	arg2	chitosan					792:799	chitosan	792:799	chitosan	792:799	The result showed that the hydrogels contained both collagen and chitosan.
33657015	6	24	contain	contained	764:772	arg1	hydrogels					754:762	the hydrogels	750:762	the hydrogels	750:762	The result showed that the hydrogels contained both collagen and chitosan.
33657015	8	25	theme	collagen	1023:1030	arg1	ratio					1041:1045	the initial collagen:chitosan ratio	1011:1045	the initial collagen:chitosan ratio	1011:1045	Collagen was distributed homogeneously and its content was related to the initial collagen:chitosan ratio.
33657015	0	26	theme	tube-like	32:40	arg1	hydrogels					60:68	tube-like collagen-chitosan hydrogels	32:68	tube-like collagen-chitosan hydrogels	32:68	Electro-deposition synthesis of tube-like collagen-chitosan hydrogels and their biological performance.
33657015	1	27	theme	smart	128:132	arg1	method					154:159	a smart, safe and efficient method	126:159	a smart, safe and efficient method for biomaterial manufacturing	126:189	Electro-deposition is a smart, safe and efficient method for biomaterial manufacturing.
33657015	1	27	theme	smart	128:132	arg1	Electro-deposition					104:121	Electro-deposition	104:121	Electro-deposition	104:121	Electro-deposition is a smart, safe and efficient method for biomaterial manufacturing.
33657015	5	28	dep	Fourier	619:625	arg1	transform					627:635	transform	627:635	transform infrared spectroscopy	627:657	Fourier transform infrared spectroscopy was employed to analyze the ingredients of the tube-like hydrogels.
33657015	9	29	theme	thermal	1101:1107	arg1	stability					1109:1117	the thermal stability	1097:1117	the thermal stability of collagen	1097:1129	The tension resistance of the composite gels and the thermal stability of collagen in the composites were obviously enhanced by the chitosan doping.
33657015	10	30	theme	good	1243:1246	arg1	ability					1248:1254	a good ability	1241:1254	a good ability to promote cell proliferation of collagen	1241:1296	Meanwhile, the tube-like hydrogels retained a good ability to promote cell proliferation of collagen.
33657015	7	31	from	content	823:829	arg1	hydrogels					850:858	the hydrogels	846:858	the hydrogels	846:858	The distribution and content of collagen in the hydrogels was further measured by hematoxylin-eosin staining and hydroxyproline titration.
33657015	2	32	theme	functional	204:213	arg1	Collagen					192:199	Collagen	192:199	Collagen	192:199	Collagen, a functional protein with excellent biocompatibility and biosafety, is a promising candidate for tissue engineering and biomedical applications.
33657015	2	32	theme	functional	204:213	arg1	protein					215:221	a functional protein	202:221	a functional protein with excellent biocompatibility and biosafety	202:267	Collagen, a functional protein with excellent biocompatibility and biosafety, is a promising candidate for tissue engineering and biomedical applications.
33657015	8	33	theme	chitosan	1032:1039	arg1	ratio					1041:1045	the initial collagen:chitosan ratio	1011:1045	the initial collagen:chitosan ratio	1011:1045	Collagen was distributed homogeneously and its content was related to the initial collagen:chitosan ratio.
33657015	3	34	theme	active	468:473	arg1	nanoparticles					475:487	electrically or magnetically active nanoparticles	439:487	electrically or magnetically active nanoparticles	439:487	However, there are few reports on electro-deposition of biomaterials using collagen without electrically or magnetically active nanoparticles.
33657015	0	35	theme	collagen-chitosan	42:58	arg1	hydrogels					60:68	tube-like collagen-chitosan hydrogels	32:68	tube-like collagen-chitosan hydrogels	32:68	Electro-deposition synthesis of tube-like collagen-chitosan hydrogels and their biological performance.
33657015	9	36	from	resistance	1060:1069	arg1	composites					1138:1147	the composites	1134:1147	the composites	1134:1147	The tension resistance of the composite gels and the thermal stability of collagen in the composites were obviously enhanced by the chitosan doping.
33657015	11	37	theme	collagen	1522:1529	arg1	stability					1509:1517	the stability	1505:1517	the stability of collagen	1505:1529	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	11	37	theme	collagen	1522:1529	arg1	strength					1547:1554	the tensile strength	1535:1554	the tensile strength of collagen-based materials	1535:1582	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	9	38	theme	composite	1078:1086	arg1	gels					1088:1091	the composite gels	1074:1091	the composite gels	1074:1091	The tension resistance of the composite gels and the thermal stability of collagen in the composites were obviously enhanced by the chitosan doping.
33657015	9	39	theme	collagen	1122:1129	arg1	stability					1109:1117	the thermal stability	1097:1117	the thermal stability of collagen	1097:1129	The tension resistance of the composite gels and the thermal stability of collagen in the composites were obviously enhanced by the chitosan doping.
33657015	9	39	theme	collagen	1122:1129	arg1	resistance					1060:1069	The tension resistance	1048:1069	The tension resistance of the composite gels	1048:1091	The tension resistance of the composite gels and the thermal stability of collagen in the composites were obviously enhanced by the chitosan doping.
33657015	4	40	theme	mild	601:604	arg1	environment					606:616	a mild environment	599:616	a mild environment	599:616	In this study, electro-deposition was employed to swiftly fabricate tube-like collagen-chitosan hydrogels in a mild environment.
33657015	11	41	theme	collagen-based	1373:1386	arg1	materials					1388:1396	collagen-based materials	1373:1396	collagen-based materials	1373:1396	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	10	42	theme	tube-like	1212:1220	arg1	Meanwhile					1197:1205	Meanwhile	1197:1205	Meanwhile	1197:1205	Meanwhile, the tube-like hydrogels retained a good ability to promote cell proliferation of collagen.
33657015	10	42	theme	tube-like	1212:1220	arg1	hydrogels					1222:1230	the tube-like hydrogels	1208:1230	the tube-like hydrogels	1208:1230	Meanwhile, the tube-like hydrogels retained a good ability to promote cell proliferation of collagen.
33657015	1	43	theme	safe	135:138	arg1	method					154:159	a smart, safe and efficient method	126:159	a smart, safe and efficient method for biomaterial manufacturing	126:189	Electro-deposition is a smart, safe and efficient method for biomaterial manufacturing.
33657015	1	43	theme	safe	135:138	arg1	Electro-deposition					104:121	Electro-deposition	104:121	Electro-deposition	104:121	Electro-deposition is a smart, safe and efficient method for biomaterial manufacturing.
33657015	10	44	theme	cell	1267:1270	arg1	proliferation					1272:1284	cell proliferation	1267:1284	cell proliferation of collagen	1267:1296	Meanwhile, the tube-like hydrogels retained a good ability to promote cell proliferation of collagen.
33657015	11	45	theme	materials	1388:1396	arg1	design					1347:1352	design	1347:1352	design	1347:1352	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	11	45	theme	materials	1388:1396	arg1	fabrication					1358:1368	fabrication	1358:1368	fabrication	1358:1368	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	11	46	dep	bioactivity	1434:1444	arg1	the					1430:1432	the	1430:1432	the	1430:1432	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	2	47	theme	excellent	228:236	arg1	biocompatibility					238:253	excellent biocompatibility	228:253	excellent biocompatibility	228:253	Collagen, a functional protein with excellent biocompatibility and biosafety, is a promising candidate for tissue engineering and biomedical applications.
33657015	1	48	theme	efficient	144:152	arg1	method					154:159	a smart, safe and efficient method	126:159	a smart, safe and efficient method for biomaterial manufacturing	126:189	Electro-deposition is a smart, safe and efficient method for biomaterial manufacturing.
33657015	1	48	theme	efficient	144:152	arg1	Electro-deposition					104:121	Electro-deposition	104:121	Electro-deposition	104:121	Electro-deposition is a smart, safe and efficient method for biomaterial manufacturing.
33657015	11	49	theme	new	1486:1488	arg1	way					1490:1492	a new way	1484:1492	a new way to enhance the stability of collagen and the tensile strength of collagen-based materials	1484:1582	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	11	50	theme	collagen	1463:1470	arg1	biosafety					1450:1458	biosafety	1450:1458	biosafety	1450:1458	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	11	50	theme	collagen	1463:1470	arg1	bioactivity					1434:1444	bioactivity	1434:1444	bioactivity	1434:1444	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	1	51	theme	biomaterial	165:175	arg1	manufacturing					177:189	biomaterial manufacturing	165:189	biomaterial manufacturing	165:189	Electro-deposition is a smart, safe and efficient method for biomaterial manufacturing.
33657015	11	52	theme	tensile	1539:1545	arg1	strength					1547:1554	the tensile strength	1535:1554	the tensile strength of collagen-based materials	1535:1582	This method offers a convenient approach to the design and fabrication of collagen-based materials, which could effectively retain the bioactivity and biosafety of collagen and furnish a new way to enhance the stability of collagen and the tensile strength of collagen-based materials.
33657015	3	53	theme	few	366:368	arg1	reports					370:376	few reports	366:376	few reports on electro-deposition of biomaterials using collagen without electrically or magnetically active nanoparticles	366:487	However, there are few reports on electro-deposition of biomaterials using collagen without electrically or magnetically active nanoparticles.
33657015	3	54	from	reports	370:376	arg1	electro-deposition					381:398	electro-deposition	381:398	electro-deposition of biomaterials using collagen without electrically or magnetically active nanoparticles	381:487	However, there are few reports on electro-deposition of biomaterials using collagen without electrically or magnetically active nanoparticles.
33657015	2	55	theme	promising	275:283	arg1	Collagen					192:199	Collagen	192:199	Collagen	192:199	Collagen, a functional protein with excellent biocompatibility and biosafety, is a promising candidate for tissue engineering and biomedical applications.
33657015	2	55	theme	promising	275:283	arg1	candidate					285:293	a promising candidate	273:293	a promising candidate for tissue engineering and biomedical applications	273:344	Collagen, a functional protein with excellent biocompatibility and biosafety, is a promising candidate for tissue engineering and biomedical applications.
33657015	0	56	theme	biological	80:89	arg1	performance					91:101	their biological performance	74:101	their biological performance	74:101	Electro-deposition synthesis of tube-like collagen-chitosan hydrogels and their biological performance.
33657015	10	57	theme	collagen	1289:1296	arg1	proliferation					1272:1284	cell proliferation	1267:1284	cell proliferation of collagen	1267:1296	Meanwhile, the tube-like hydrogels retained a good ability to promote cell proliferation of collagen.
33657015	2	58	with	protein	215:221	arg1	biosafety					259:267	biosafety	259:267	biosafety	259:267	Collagen, a functional protein with excellent biocompatibility and biosafety, is a promising candidate for tissue engineering and biomedical applications.
33657015	2	58	with	protein	215:221	arg1	biocompatibility					238:253	excellent biocompatibility	228:253	excellent biocompatibility	228:253	Collagen, a functional protein with excellent biocompatibility and biosafety, is a promising candidate for tissue engineering and biomedical applications.
33657015	7	59	theme	hematoxylin-eosin	884:900	arg1	staining					902:909	hematoxylin-eosin staining	884:909	hematoxylin-eosin staining	884:909	The distribution and content of collagen in the hydrogels was further measured by hematoxylin-eosin staining and hydroxyproline titration.
34405429	8	0	theme	quality	1258:1264	arg1	pathways					1274:1281	protein quality control pathways	1250:1281	protein quality control pathways	1250:1281	RESULTS Accumulated proteins were mainly components of glycogen metabolism and protein quality control pathways.
34405429	12	1	theme	storage	1981:1987	arg1	pathobiology					1952:1963	the pathobiology	1948:1963	the pathobiology of polyglucosan storage	1948:1987	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	5	2	theme	stained	733:739	arg1	sections					748:755	Histologically stained tissue sections	718:755	Histologically stained tissue sections of skeletal muscle from four patients	718:793	Histologically stained tissue sections of skeletal muscle from four patients were used to isolate polyglucosan deposits and control regions by laser microdissection.
34405429	4	3	theme	blot	626:629	arg1	analyses					631:638	western blot analyses	618:638	western blot analyses	618:638	METHODS We combined quantitative mass spectrometry, immunohistochemical and western blot analyses to identify the principal protein components of polyglucosan bodies in PGBM1.
34405429	8	4	theme	pathways	1274:1281	arg1	components					1212:1221	components	1212:1221	components of glycogen metabolism and protein quality control pathways	1212:1281	RESULTS Accumulated proteins were mainly components of glycogen metabolism and protein quality control pathways.
34405429	6	5	theme	quantitative	968:979	arg1	comparison					981:990	quantitative comparison	968:990	quantitative comparison	968:990	Prior to mass spectrometry, samples were labelled with tandem mass tags that enable quantitative comparison and multiplexed analysis of dissected samples.
34405429	10	6	theme	autophagocytosis	1523:1538	arg1	systems					1540:1546	the ubiquitin-proteasome and autophagocytosis systems	1494:1546	systems	1540:1546	The polyglucosan bodies also showed accumulation of proteins involved in the ubiquitin-proteasome and autophagocytosis systems and protein chaperones.
34405429	11	7	theme	function	1727:1734	arg1	impairment					1736:1745	muscle function impairment	1720:1745	muscle function impairment	1720:1745	CONCLUSIONS The sequestration of key enzymes of glycogen metabolism to the polyglucosan bodies may explain the glycogen depletion in the fibres and muscle function impairment.
34405429	6	8	theme	mass	946:949	arg1	tags					951:954	tandem mass tags	939:954	tandem mass tags that enable quantitative comparison and multiplexed analysis of dissected samples	939:1036	Prior to mass spectrometry, samples were labelled with tandem mass tags that enable quantitative comparison and multiplexed analysis of dissected samples.
34405429	5	9	theme	tissue	741:746	arg1	sections					748:755	Histologically stained tissue sections	718:755	Histologically stained tissue sections of skeletal muscle from four patients	718:793	Histologically stained tissue sections of skeletal muscle from four patients were used to isolate polyglucosan deposits and control regions by laser microdissection.
34405429	9	10	theme	glycogen	1327:1334	arg1	redistribution					1340:1353	redistribution	1340:1353	redistribution of key enzymes of glycogen metabolism to the polyglucosan bodies	1340:1418	The majority of fibres showed depletion of glycogen and redistribution of key enzymes of glycogen metabolism to the polyglucosan bodies.
34405429	9	10	theme	glycogen	1327:1334	arg1	depletion					1314:1322	depletion	1314:1322	depletion of glycogen	1314:1334	The majority of fibres showed depletion of glycogen and redistribution of key enzymes of glycogen metabolism to the polyglucosan bodies.
34405429	12	11	theme	components	1768:1777	arg1	accumulation					1752:1763	The accumulation	1748:1763	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders	1748:1883	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	5	12	theme	muscle	769:774	arg1	sections					748:755	Histologically stained tissue sections	718:755	Histologically stained tissue sections of skeletal muscle from four patients	718:793	Histologically stained tissue sections of skeletal muscle from four patients were used to isolate polyglucosan deposits and control regions by laser microdissection.
34405429	2	13	theme	Lafora	327:332	arg1	disease					334:340	Lafora disease	327:340	Lafora disease	327:340	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	2	13	theme	Lafora	327:332	arg1	type					424:427	polyglucosan body myopathy type 1	397:429	polyglucosan body myopathy type 1 (PGBM1)	397:437	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	2	13	theme	Lafora	327:332	arg1	deficiency					385:394	glycogenin-1 deficiency	372:394	glycogenin-1 deficiency	372:394	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	2	13	theme	Lafora	327:332	arg1	deficiency					360:369	branching enzyme deficiency	343:369	branching enzyme deficiency	343:369	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	1	14	theme	amylopectin-like	222:237	arg1	polysaccharides					239:253	amylopectin-like polysaccharides	222:253	amylopectin-like polysaccharides	222:253	AIMS Several neurodegenerative and neuromuscular disorders are characterised by storage of polyglucosan, consisting of proteins and amylopectin-like polysaccharides, which are less branched than in normal glycogen.
34405429	4	15	theme	bodies	701:706	arg1	components					674:683	the principal protein components	652:683	the principal protein components of polyglucosan bodies in PGBM1	652:715	METHODS We combined quantitative mass spectrometry, immunohistochemical and western blot analyses to identify the principal protein components of polyglucosan bodies in PGBM1.
34405429	5	16	from	patients	786:793	arg1	sections					748:755	Histologically stained tissue sections	718:755	Histologically stained tissue sections of skeletal muscle from four patients	718:793	Histologically stained tissue sections of skeletal muscle from four patients were used to isolate polyglucosan deposits and control regions by laser microdissection.
34405429	7	17	theme	proteins	1099:1106	arg1	expression					1069:1078	expression	1069:1078	expression	1069:1078	To study the distribution and expression of the accumulated proteins, immunohistochemical and western blot analyses were performed.
34405429	7	17	theme	proteins	1099:1106	arg1	distribution					1052:1063	distribution	1052:1063	distribution	1052:1063	To study the distribution and expression of the accumulated proteins, immunohistochemical and western blot analyses were performed.
34405429	6	18	theme	dissected	1020:1028	arg1	samples					1030:1036	dissected samples	1020:1036	dissected samples	1020:1036	Prior to mass spectrometry, samples were labelled with tandem mass tags that enable quantitative comparison and multiplexed analysis of dissected samples.
34405429	8	19	dep	RESULTS	1171:1177	arg1	components					1212:1221	components	1212:1221	components of glycogen metabolism and protein quality control pathways	1212:1281	RESULTS Accumulated proteins were mainly components of glycogen metabolism and protein quality control pathways.
34405429	7	20	theme	blot	1141:1144	arg1	analyses					1146:1153	western blot analyses	1133:1153	western blot analyses	1133:1153	To study the distribution and expression of the accumulated proteins, immunohistochemical and western blot analyses were performed.
34405429	1	21	from	branched	271:278	arg1	glycogen					295:302	normal glycogen	288:302	normal glycogen	288:302	AIMS Several neurodegenerative and neuromuscular disorders are characterised by storage of polyglucosan, consisting of proteins and amylopectin-like polysaccharides, which are less branched than in normal glycogen.
34405429	9	22	theme	metabolism	1382:1391	arg1	enzymes					1362:1368	key enzymes	1358:1368	key enzymes of glycogen metabolism	1358:1391	The majority of fibres showed depletion of glycogen and redistribution of key enzymes of glycogen metabolism to the polyglucosan bodies.
34405429	5	23	theme	polyglucosan	816:827	arg1	deposits					829:836	polyglucosan deposits	816:836	polyglucosan deposits	816:836	Histologically stained tissue sections of skeletal muscle from four patients were used to isolate polyglucosan deposits and control regions by laser microdissection.
34405429	12	24	theme	protein	1857:1863	arg1	disorders					1875:1883	protein aggregate disorders	1857:1883	protein aggregate disorders	1857:1883	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	11	25	theme	glycogen	1683:1690	arg1	depletion					1692:1700	the glycogen depletion	1679:1700	the glycogen depletion	1679:1700	CONCLUSIONS The sequestration of key enzymes of glycogen metabolism to the polyglucosan bodies may explain the glycogen depletion in the fibres and muscle function impairment.
34405429	5	26	used	used	800:803	arg2	sections					748:755	Histologically stained tissue sections	718:755	Histologically stained tissue sections of skeletal muscle from four patients	718:793	Histologically stained tissue sections of skeletal muscle from four patients were used to isolate polyglucosan deposits and control regions by laser microdissection.
34405429	1	27	theme	polyglucosan	181:192	arg1	storage					170:176	storage	170:176	storage of polyglucosan, consisting of proteins and amylopectin-like polysaccharides, which are less branched than in normal glycogen	170:302	AIMS Several neurodegenerative and neuromuscular disorders are characterised by storage of polyglucosan, consisting of proteins and amylopectin-like polysaccharides, which are less branched than in normal glycogen.
34405429	12	28	located	found	1848:1852	arg1	disorders					1875:1883	protein aggregate disorders	1857:1883	protein aggregate disorders	1857:1883	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	12	28	located	found	1848:1852	arg2	systems					1810:1816	protein quality control systems	1786:1816	protein quality control systems	1786:1816	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	9	29	theme	fibres	1300:1305	arg1	majority					1288:1295	The majority	1284:1295	The majority of fibres	1284:1305	The majority of fibres showed depletion of glycogen and redistribution of key enzymes of glycogen metabolism to the polyglucosan bodies.
34405429	11	30	theme	enzymes	1609:1615	arg1	sequestration					1588:1600	The sequestration	1584:1600	The sequestration of key enzymes of glycogen metabolism to the polyglucosan bodies	1584:1665	CONCLUSIONS The sequestration of key enzymes of glycogen metabolism to the polyglucosan bodies may explain the glycogen depletion in the fibres and muscle function impairment.
34405429	12	31	theme	proteins	1828:1835	arg1	components					1768:1777	components	1768:1777	components of the protein quality control systems and other proteins frequently found in protein aggregate disorders	1768:1883	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	11	32	theme	key	1605:1607	arg1	enzymes					1609:1615	key enzymes	1605:1615	key enzymes of glycogen metabolism	1605:1638	CONCLUSIONS The sequestration of key enzymes of glycogen metabolism to the polyglucosan bodies may explain the glycogen depletion in the fibres and muscle function impairment.
34405429	0	33	theme	Proteomic	0:8	arg1	characterisation					10:25	Proteomic characterisation	0:25	Proteomic characterisation of polyglucosan bodies in skeletal muscle in RBCK1 deficiency.	0:88	Proteomic characterisation of polyglucosan bodies in skeletal muscle in RBCK1 deficiency.
34405429	1	34	theme	Several	95:101	arg1	disorders					139:147	Several neurodegenerative and neuromuscular disorders	95:147	Several neurodegenerative and neuromuscular disorders	95:147	AIMS Several neurodegenerative and neuromuscular disorders are characterised by storage of polyglucosan, consisting of proteins and amylopectin-like polysaccharides, which are less branched than in normal glycogen.
34405429	12	35	theme	control	1802:1808	arg1	systems					1810:1816	protein quality control systems	1786:1816	protein quality control systems	1786:1816	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	11	36	theme	metabolism	1629:1638	arg1	enzymes					1609:1615	key enzymes	1605:1615	key enzymes of glycogen metabolism	1605:1638	CONCLUSIONS The sequestration of key enzymes of glycogen metabolism to the polyglucosan bodies may explain the glycogen depletion in the fibres and muscle function impairment.
34405429	3	37	theme	protein	479:485	arg1	unknown					533:539	unknown	533:539	unknown	533:539	The protein composition of polyglucosan bodies is largely unknown.
34405429	3	37	theme	protein	479:485	arg1	composition					487:497	The protein composition	475:497	The protein composition of polyglucosan bodies	475:520	The protein composition of polyglucosan bodies is largely unknown.
34405429	6	38	theme	tandem	939:944	arg1	tags					951:954	tandem mass tags	939:954	tandem mass tags that enable quantitative comparison and multiplexed analysis of dissected samples	939:1036	Prior to mass spectrometry, samples were labelled with tandem mass tags that enable quantitative comparison and multiplexed analysis of dissected samples.
34405429	0	39	theme	bodies	43:48	arg1	characterisation					10:25	Proteomic characterisation	0:25	Proteomic characterisation of polyglucosan bodies in skeletal muscle in RBCK1 deficiency.	0:88	Proteomic characterisation of polyglucosan bodies in skeletal muscle in RBCK1 deficiency.
34405429	4	40	dep	METHODS	542:548	arg1	combined					553:560	combined	553:560	combined quantitative mass spectrometry, immunohistochemical and western blot analyses to identify the principal protein components of polyglucosan bodies in PGBM1	553:715	METHODS We combined quantitative mass spectrometry, immunohistochemical and western blot analyses to identify the principal protein components of polyglucosan bodies in PGBM1.
34405429	12	41	dep	systems	1810:1816	arg1	the					1782:1784	the	1782:1784	the	1782:1784	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	3	42	theme	bodies	515:520	arg1	unknown					533:539	unknown	533:539	unknown	533:539	The protein composition of polyglucosan bodies is largely unknown.
34405429	3	42	theme	bodies	515:520	arg1	composition					487:497	The protein composition	475:497	The protein composition of polyglucosan bodies	475:520	The protein composition of polyglucosan bodies is largely unknown.
34405429	5	43	theme	laser	861:865	arg1	microdissection					867:881	laser microdissection	861:881	laser microdissection	861:881	Histologically stained tissue sections of skeletal muscle from four patients were used to isolate polyglucosan deposits and control regions by laser microdissection.
34405429	4	44	theme	quantitative	562:573	arg1	spectrometry					580:591	quantitative mass spectrometry	562:591	quantitative mass spectrometry	562:591	METHODS We combined quantitative mass spectrometry, immunohistochemical and western blot analyses to identify the principal protein components of polyglucosan bodies in PGBM1.
34405429	12	45	theme	polyglucosan	1968:1979	arg1	storage					1981:1987	polyglucosan storage	1968:1987	polyglucosan storage	1968:1987	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	2	46	theme	body	410:413	arg1	disease					334:340	Lafora disease	327:340	Lafora disease	327:340	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	2	46	theme	body	410:413	arg1	type					424:427	polyglucosan body myopathy type 1	397:429	polyglucosan body myopathy type 1 (PGBM1)	397:437	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	2	46	theme	body	410:413	arg1	PGBM1					432:436	PGBM1	432:436	PGBM1	432:436	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	8	47	theme	metabolism	1235:1244	arg1	components					1212:1221	components	1212:1221	components of glycogen metabolism and protein quality control pathways	1212:1281	RESULTS Accumulated proteins were mainly components of glycogen metabolism and protein quality control pathways.
34405429	6	48	theme	multiplexed	996:1006	arg1	analysis					1008:1015	multiplexed analysis	996:1015	multiplexed analysis	996:1015	Prior to mass spectrometry, samples were labelled with tandem mass tags that enable quantitative comparison and multiplexed analysis of dissected samples.
34405429	4	49	theme	principal	656:664	arg1	components					674:683	the principal protein components	652:683	the principal protein components of polyglucosan bodies in PGBM1	652:715	METHODS We combined quantitative mass spectrometry, immunohistochemical and western blot analyses to identify the principal protein components of polyglucosan bodies in PGBM1.
34405429	8	50	theme	protein	1250:1256	arg1	pathways					1274:1281	protein quality control pathways	1250:1281	protein quality control pathways	1250:1281	RESULTS Accumulated proteins were mainly components of glycogen metabolism and protein quality control pathways.
34405429	4	51	theme	western	618:624	arg1	analyses					631:638	western blot analyses	618:638	western blot analyses	618:638	METHODS We combined quantitative mass spectrometry, immunohistochemical and western blot analyses to identify the principal protein components of polyglucosan bodies in PGBM1.
34405429	1	52	theme	normal	288:293	arg1	glycogen					295:302	normal glycogen	288:302	normal glycogen	288:302	AIMS Several neurodegenerative and neuromuscular disorders are characterised by storage of polyglucosan, consisting of proteins and amylopectin-like polysaccharides, which are less branched than in normal glycogen.
34405429	8	53	theme	control	1266:1272	arg1	pathways					1274:1281	protein quality control pathways	1250:1281	protein quality control pathways	1250:1281	RESULTS Accumulated proteins were mainly components of glycogen metabolism and protein quality control pathways.
34405429	12	54	theme	pathobiology	1952:1963	arg1	part					1940:1943	an essential part	1927:1943	an essential part of the pathobiology of polyglucosan storage	1927:1987	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	12	54	theme	pathobiology	1952:1963	arg1	aggregation					1908:1918	protein aggregation	1900:1918	protein aggregation	1900:1918	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	2	55	theme	glycogenin-1	372:383	arg1	disease					334:340	Lafora disease	327:340	Lafora disease	327:340	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	2	55	theme	glycogenin-1	372:383	arg1	deficiency					385:394	glycogenin-1 deficiency	372:394	glycogenin-1 deficiency	372:394	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	2	56	theme	Such	305:308	arg1	diseases					310:317	Such diseases	305:317	Such diseases	305:317	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	0	57	theme	skeletal	53:60	arg1	muscle					62:67	skeletal muscle	53:67	skeletal muscle in RBCK1 deficiency	53:87	Proteomic characterisation of polyglucosan bodies in skeletal muscle in RBCK1 deficiency.
34405429	2	58	theme	branching	343:351	arg1	disease					334:340	Lafora disease	327:340	Lafora disease	327:340	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	2	58	theme	branching	343:351	arg1	deficiency					360:369	branching enzyme deficiency	343:369	branching enzyme deficiency	343:369	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	12	59	theme	essential	1930:1938	arg1	part					1940:1943	an essential part	1927:1943	an essential part of the pathobiology of polyglucosan storage	1927:1987	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	12	59	theme	essential	1930:1938	arg1	aggregation					1908:1918	protein aggregation	1900:1918	protein aggregation	1900:1918	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	5	60	theme	skeletal	760:767	arg1	muscle					769:774	skeletal muscle	760:774	skeletal muscle	760:774	Histologically stained tissue sections of skeletal muscle from four patients were used to isolate polyglucosan deposits and control regions by laser microdissection.
34405429	10	61	theme	protein	1552:1558	arg1	chaperones					1560:1569	protein chaperones	1552:1569	protein chaperones	1552:1569	The polyglucosan bodies also showed accumulation of proteins involved in the ubiquitin-proteasome and autophagocytosis systems and protein chaperones.
34405429	12	62	theme	protein	1786:1792	arg1	systems					1810:1816	protein quality control systems	1786:1816	protein quality control systems	1786:1816	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	4	63	from	components	674:683	arg1	PGBM1					711:715	PGBM1	711:715	PGBM1	711:715	METHODS We combined quantitative mass spectrometry, immunohistochemical and western blot analyses to identify the principal protein components of polyglucosan bodies in PGBM1.
34405429	6	64	theme	samples	1030:1036	arg1	comparison					981:990	quantitative comparison	968:990	quantitative comparison	968:990	Prior to mass spectrometry, samples were labelled with tandem mass tags that enable quantitative comparison and multiplexed analysis of dissected samples.
34405429	6	64	theme	samples	1030:1036	arg1	analysis					1008:1015	multiplexed analysis	996:1015	multiplexed analysis	996:1015	Prior to mass spectrometry, samples were labelled with tandem mass tags that enable quantitative comparison and multiplexed analysis of dissected samples.
34405429	4	65	theme	polyglucosan	688:699	arg1	bodies					701:706	polyglucosan bodies	688:706	polyglucosan bodies	688:706	METHODS We combined quantitative mass spectrometry, immunohistochemical and western blot analyses to identify the principal protein components of polyglucosan bodies in PGBM1.
34405429	7	66	theme	western	1133:1139	arg1	analyses					1146:1153	western blot analyses	1133:1153	western blot analyses	1133:1153	To study the distribution and expression of the accumulated proteins, immunohistochemical and western blot analyses were performed.
34405429	9	67	theme	enzymes	1362:1368	arg1	redistribution					1340:1353	redistribution	1340:1353	redistribution of key enzymes of glycogen metabolism to the polyglucosan bodies	1340:1418	The majority of fibres showed depletion of glycogen and redistribution of key enzymes of glycogen metabolism to the polyglucosan bodies.
34405429	9	67	theme	enzymes	1362:1368	arg1	depletion					1314:1322	depletion	1314:1322	depletion of glycogen	1314:1334	The majority of fibres showed depletion of glycogen and redistribution of key enzymes of glycogen metabolism to the polyglucosan bodies.
34405429	1	68	theme	neuromuscular	125:137	arg1	disorders					139:147	Several neurodegenerative and neuromuscular disorders	95:147	Several neurodegenerative and neuromuscular disorders	95:147	AIMS Several neurodegenerative and neuromuscular disorders are characterised by storage of polyglucosan, consisting of proteins and amylopectin-like polysaccharides, which are less branched than in normal glycogen.
34405429	11	69	theme	polyglucosan	1647:1658	arg1	bodies					1660:1665	the polyglucosan bodies	1643:1665	the polyglucosan bodies	1643:1665	CONCLUSIONS The sequestration of key enzymes of glycogen metabolism to the polyglucosan bodies may explain the glycogen depletion in the fibres and muscle function impairment.
34405429	11	70	theme	muscle	1720:1725	arg1	impairment					1736:1745	muscle function impairment	1720:1745	muscle function impairment	1720:1745	CONCLUSIONS The sequestration of key enzymes of glycogen metabolism to the polyglucosan bodies may explain the glycogen depletion in the fibres and muscle function impairment.
34405429	9	71	theme	glycogen	1373:1380	arg1	metabolism					1382:1391	glycogen metabolism	1373:1391	glycogen metabolism	1373:1391	The majority of fibres showed depletion of glycogen and redistribution of key enzymes of glycogen metabolism to the polyglucosan bodies.
34405429	7	72	theme	accumulated	1087:1097	arg1	proteins					1099:1106	the accumulated proteins	1083:1106	the accumulated proteins	1083:1106	To study the distribution and expression of the accumulated proteins, immunohistochemical and western blot analyses were performed.
34405429	11	73	dep	CONCLUSIONS	1572:1582	arg1	explain					1671:1677	explain	1671:1677	may explain the glycogen depletion in the fibres and muscle function impairment	1667:1745	CONCLUSIONS The sequestration of key enzymes of glycogen metabolism to the polyglucosan bodies may explain the glycogen depletion in the fibres and muscle function impairment.
34405429	0	74	theme	RBCK1	72:76	arg1	deficiency					78:87	RBCK1 deficiency	72:87	RBCK1 deficiency	72:87	Proteomic characterisation of polyglucosan bodies in skeletal muscle in RBCK1 deficiency.
34405429	12	75	theme	protein	1900:1906	arg1	part					1940:1943	an essential part	1927:1943	an essential part of the pathobiology of polyglucosan storage	1927:1987	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	12	75	theme	protein	1900:1906	arg1	aggregation					1908:1918	protein aggregation	1900:1918	protein aggregation	1900:1918	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	9	76	theme	polyglucosan	1400:1411	arg1	bodies					1413:1418	the polyglucosan bodies	1396:1418	the polyglucosan bodies	1396:1418	The majority of fibres showed depletion of glycogen and redistribution of key enzymes of glycogen metabolism to the polyglucosan bodies.
34405429	1	77	from	glycogen	295:302	arg1	branched					271:278	branched	271:278	branched	271:278	AIMS Several neurodegenerative and neuromuscular disorders are characterised by storage of polyglucosan, consisting of proteins and amylopectin-like polysaccharides, which are less branched than in normal glycogen.
34405429	0	78	from	characterisation	10:25	arg1	muscle					62:67	skeletal muscle	53:67	skeletal muscle in RBCK1 deficiency	53:87	Proteomic characterisation of polyglucosan bodies in skeletal muscle in RBCK1 deficiency.
34405429	12	79	theme	aggregate	1865:1873	arg1	disorders					1875:1883	protein aggregate disorders	1857:1883	protein aggregate disorders	1857:1883	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	0	80	from	muscle	62:67	arg1	deficiency					78:87	RBCK1 deficiency	72:87	RBCK1 deficiency	72:87	Proteomic characterisation of polyglucosan bodies in skeletal muscle in RBCK1 deficiency.
34405429	2	81	theme	enzyme	353:358	arg1	disease					334:340	Lafora disease	327:340	Lafora disease	327:340	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	2	81	theme	enzyme	353:358	arg1	deficiency					360:369	branching enzyme deficiency	343:369	branching enzyme deficiency	343:369	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	12	82	theme	other	1822:1826	arg1	proteins					1828:1835	other proteins	1822:1835	other proteins	1822:1835	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	11	83	theme	glycogen	1620:1627	arg1	metabolism					1629:1638	glycogen metabolism	1620:1638	glycogen metabolism	1620:1638	CONCLUSIONS The sequestration of key enzymes of glycogen metabolism to the polyglucosan bodies may explain the glycogen depletion in the fibres and muscle function impairment.
34405429	2	84	theme	myopathy	415:422	arg1	disease					334:340	Lafora disease	327:340	Lafora disease	327:340	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	2	84	theme	myopathy	415:422	arg1	type					424:427	polyglucosan body myopathy type 1	397:429	polyglucosan body myopathy type 1 (PGBM1)	397:437	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	2	84	theme	myopathy	415:422	arg1	PGBM1					432:436	PGBM1	432:436	PGBM1	432:436	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	0	85	theme	polyglucosan	30:41	arg1	bodies					43:48	polyglucosan bodies	30:48	polyglucosan bodies	30:48	Proteomic characterisation of polyglucosan bodies in skeletal muscle in RBCK1 deficiency.
34405429	8	86	theme	Accumulated	1179:1189	arg1	proteins					1191:1198	Accumulated proteins	1179:1198	Accumulated proteins	1179:1198	RESULTS Accumulated proteins were mainly components of glycogen metabolism and protein quality control pathways.
34405429	1	87	theme	neurodegenerative	103:119	arg1	disorders					139:147	Several neurodegenerative and neuromuscular disorders	95:147	Several neurodegenerative and neuromuscular disorders	95:147	AIMS Several neurodegenerative and neuromuscular disorders are characterised by storage of polyglucosan, consisting of proteins and amylopectin-like polysaccharides, which are less branched than in normal glycogen.
34405429	12	88	theme	quality	1794:1800	arg1	systems					1810:1816	protein quality control systems	1786:1816	protein quality control systems	1786:1816	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	2	89	theme	RBCK1	446:450	arg1	deficiency					452:461	RBCK1 deficiency	446:461	RBCK1 deficiency	446:461	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	10	90	theme	polyglucosan	1425:1436	arg1	bodies					1438:1443	The polyglucosan bodies	1421:1443	The polyglucosan bodies	1421:1443	The polyglucosan bodies also showed accumulation of proteins involved in the ubiquitin-proteasome and autophagocytosis systems and protein chaperones.
34405429	5	91	theme	control	842:848	arg1	regions					850:856	control regions	842:856	control regions	842:856	Histologically stained tissue sections of skeletal muscle from four patients were used to isolate polyglucosan deposits and control regions by laser microdissection.
34405429	12	92	theme	systems	1810:1816	arg1	components					1768:1777	components	1768:1777	components of the protein quality control systems and other proteins frequently found in protein aggregate disorders	1768:1883	The accumulation of components of the protein quality control systems and other proteins frequently found in protein aggregate disorders indicates that protein aggregation may be an essential part of the pathobiology of polyglucosan storage.
34405429	10	93	theme	proteins	1473:1480	arg1	accumulation					1457:1468	accumulation	1457:1468	accumulation of proteins involved in the ubiquitin-proteasome and autophagocytosis systems and protein chaperones	1457:1569	The polyglucosan bodies also showed accumulation of proteins involved in the ubiquitin-proteasome and autophagocytosis systems and protein chaperones.
34405429	4	94	theme	mass	575:578	arg1	spectrometry					580:591	quantitative mass spectrometry	562:591	quantitative mass spectrometry	562:591	METHODS We combined quantitative mass spectrometry, immunohistochemical and western blot analyses to identify the principal protein components of polyglucosan bodies in PGBM1.
34405429	9	95	theme	key	1358:1360	arg1	enzymes					1362:1368	key enzymes	1358:1368	key enzymes of glycogen metabolism	1358:1391	The majority of fibres showed depletion of glycogen and redistribution of key enzymes of glycogen metabolism to the polyglucosan bodies.
34405429	8	96	theme	glycogen	1226:1233	arg1	metabolism					1235:1244	glycogen metabolism	1226:1244	glycogen metabolism	1226:1244	RESULTS Accumulated proteins were mainly components of glycogen metabolism and protein quality control pathways.
34405429	10	97	theme	ubiquitin-proteasome	1498:1517	arg1	systems					1540:1546	the ubiquitin-proteasome and autophagocytosis systems	1494:1546	systems	1540:1546	The polyglucosan bodies also showed accumulation of proteins involved in the ubiquitin-proteasome and autophagocytosis systems and protein chaperones.
34405429	3	98	theme	polyglucosan	502:513	arg1	bodies					515:520	polyglucosan bodies	502:520	polyglucosan bodies	502:520	The protein composition of polyglucosan bodies is largely unknown.
34405429	6	99	theme	mass	893:896	arg1	spectrometry					898:909	mass spectrometry	893:909	mass spectrometry	893:909	Prior to mass spectrometry, samples were labelled with tandem mass tags that enable quantitative comparison and multiplexed analysis of dissected samples.
34405429	4	100	theme	protein	666:672	arg1	components					674:683	the principal protein components	652:683	the principal protein components of polyglucosan bodies in PGBM1	652:715	METHODS We combined quantitative mass spectrometry, immunohistochemical and western blot analyses to identify the principal protein components of polyglucosan bodies in PGBM1.
34405429	2	101	theme	polyglucosan	397:408	arg1	disease					334:340	Lafora disease	327:340	Lafora disease	327:340	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	2	101	theme	polyglucosan	397:408	arg1	type					424:427	polyglucosan body myopathy type 1	397:429	polyglucosan body myopathy type 1 (PGBM1)	397:437	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
34405429	2	101	theme	polyglucosan	397:408	arg1	PGBM1					432:436	PGBM1	432:436	PGBM1	432:436	Such diseases include Lafora disease, branching enzyme deficiency, glycogenin-1 deficiency, polyglucosan body myopathy type 1 (PGBM1) due to RBCK1 deficiency and others.
33682617	6	0	theme	HACF	1142:1145	arg1	scaffold					1156:1163	HACF hydrogel scaffold	1142:1163	HACF hydrogel scaffold	1142:1163	The results revealed that HACF hydrogel scaffold exerts anti-inflammatory effect by inhibiting the production of ROS, suppress NF-kB translocation to the nucleus and thereby inhibiting the production of inflammatory mediators.
33682617	2	1	theme	tissue	385:390	arg1	regeneration					392:403	eventual tissue regeneration	376:403	eventual tissue regeneration	376:403	They are designed to provide architectural framework of native extracellular matrix so as to encourage cell growth and eventual tissue regeneration.
33682617	6	2	theme	NF-kB	1243:1247	arg1	translocation					1249:1261	NF-kB translocation	1243:1261	NF-kB translocation	1243:1261	The results revealed that HACF hydrogel scaffold exerts anti-inflammatory effect by inhibiting the production of ROS, suppress NF-kB translocation to the nucleus and thereby inhibiting the production of inflammatory mediators.
33682617	5	3	dep	induced	1081:1087	arg1	LPS					1077:1079	LPS	1077:1079	LPS	1077:1079	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	3	4	from	by-products	588:598	arg1	processing					618:627	processing	618:627	processing into a variety of material formats	618:662	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	2	5	theme	extracellular	320:332	arg1	matrix					334:339	native extracellular matrix	313:339	native extracellular matrix	313:339	They are designed to provide architectural framework of native extracellular matrix so as to encourage cell growth and eventual tissue regeneration.
33682617	6	6	theme	inflammatory	1319:1330	arg1	mediators					1332:1340	inflammatory mediators	1319:1340	inflammatory mediators	1319:1340	The results revealed that HACF hydrogel scaffold exerts anti-inflammatory effect by inhibiting the production of ROS, suppress NF-kB translocation to the nucleus and thereby inhibiting the production of inflammatory mediators.
33682617	5	7	theme	HACF	914:917	arg1	effects					903:909	The effects	899:909	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	7	theme	HACF	914:917	arg1	levels					1008:1013	the mRNA levels	999:1013	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	8	theme	nitrite	955:961	arg1	viability					926:934	the viability	922:934	the viability of RAW264.7 cells	922:952	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	8	theme	nitrite	955:961	arg1	level					963:967	nitrite level	955:967	nitrite level	955:967	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	7	9	theme	signaling	1487:1495	arg1	pathway					1497:1503	NF-kB signaling pathway	1481:1503	NF-kB signaling pathway	1481:1503	Hence, our results confirm that HACF has a strong anti-oxidant capacity to inhibit inflammation associated gene expression by suppressing NF-kB signaling pathway.
33682617	3	10	theme	material	647:654	arg1	formats					656:662	material formats	647:662	material formats	647:662	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	1	11	theme	integral	215:222	arg1	component					224:232	an integral component	212:232	an integral component of tissue engineering	212:254	Biomaterials serve as an integral component of tissue engineering.
33682617	1	11	theme	integral	215:222	arg1	Biomaterials					190:201	Biomaterials	190:201	Biomaterials	190:201	Biomaterials serve as an integral component of tissue engineering.
33682617	4	12	theme	marine	721:726	arg1	macromolecules					728:741	marine macromolecules	721:741	marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells	721:896	Here we studied in vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells.
33682617	3	13	theme	degradation	576:586	arg1	by-products					588:598	degradation by-products	576:598	degradation by-products	576:598	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	0	14	theme	cartilage	147:155	arg1	applications					176:187	cartilage tissue engineering applications	147:187	cartilage tissue engineering applications	147:187	In vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications.
33682617	5	15	theme	cells	948:952	arg1	viability					926:934	the viability	922:934	the viability of RAW264.7 cells	922:952	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	15	theme	cells	948:952	arg1	level					963:967	nitrite level	955:967	nitrite level	955:967	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	15	theme	cells	948:952	arg1	ROS					984:986	intracellular ROS	970:986	intracellular ROS	970:986	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	7	16	theme	associated	1439:1448	arg1	expression					1455:1464	inflammation associated gene expression	1426:1464	inflammation associated gene expression	1426:1464	Hence, our results confirm that HACF has a strong anti-oxidant capacity to inhibit inflammation associated gene expression by suppressing NF-kB signaling pathway.
33682617	0	17	theme	engineering	164:174	arg1	applications					176:187	cartilage tissue engineering applications	147:187	cartilage tissue engineering applications	147:187	In vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications.
33682617	5	18	theme	induced	1081:1087	arg1	cells					1109:1113	LPS induced RAW264.7 macrophage cells	1077:1113	LPS induced RAW264.7 macrophage cells	1077:1113	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	19	theme	RAW264.7	1089:1096	arg1	cells					1109:1113	LPS induced RAW264.7 macrophage cells	1077:1113	LPS induced RAW264.7 macrophage cells	1077:1113	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	20	theme	macrophage	1098:1107	arg1	cells					1109:1113	LPS induced RAW264.7 macrophage cells	1077:1113	LPS induced RAW264.7 macrophage cells	1077:1113	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	2	21	theme	architectural	286:298	arg1	framework					300:308	architectural framework	286:308	architectural framework of native extracellular matrix so as to encourage cell growth and eventual tissue regeneration	286:403	They are designed to provide architectural framework of native extracellular matrix so as to encourage cell growth and eventual tissue regeneration.
33682617	8	22	theme	HACF	1574:1577	arg1	scaffold					1588:1595	HACF hydrogel scaffold	1574:1595	HACF hydrogel scaffold	1574:1595	It clearly reveals the anti-oxidant and anti-inflammatory effect of HACF hydrogel scaffold on LPS induced RAW 264.7 cells.
33682617	0	23	theme	bio-composite	75:87	arg1	scaffold					89:96	bio-composite scaffold	75:96	bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications	75:187	In vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications.
33682617	8	24	theme	scaffold	1588:1595	arg1	effect					1564:1569	the anti-oxidant and anti-inflammatory effect	1525:1569	the anti-oxidant and anti-inflammatory effect of HACF hydrogel scaffold on LPS induced RAW 264.7 cells	1525:1626	It clearly reveals the anti-oxidant and anti-inflammatory effect of HACF hydrogel scaffold on LPS induced RAW 264.7 cells.
33682617	4	25	theme	RAW	871:873	arg1	cells					892:896	LPS stimulated RAW 264.7 macrophage cells	856:896	LPS stimulated RAW 264.7 macrophage cells	856:896	Here we studied in vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells.
33682617	0	26	theme	stimulated	105:114	arg1	cells					137:141	LPS stimulated RAW 264.7 macrophage cells	101:141	LPS stimulated RAW 264.7 macrophage cells	101:141	In vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications.
33682617	5	27	theme	COX-2	1031:1035	arg1	effects					903:909	The effects	899:909	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	27	theme	COX-2	1031:1035	arg1	levels					1008:1013	the mRNA levels	999:1013	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	8	28	theme	RAW	1612:1614	arg1	cells					1622:1626	LPS induced RAW 264.7 cells	1600:1626	LPS induced RAW 264.7 cells	1600:1626	It clearly reveals the anti-oxidant and anti-inflammatory effect of HACF hydrogel scaffold on LPS induced RAW 264.7 cells.
33682617	4	29	theme	macrophage	881:890	arg1	cells					892:896	LPS stimulated RAW 264.7 macrophage cells	856:896	LPS stimulated RAW 264.7 macrophage cells	856:896	Here we studied in vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells.
33682617	8	30	from	effect	1564:1569	arg1	cells					1622:1626	LPS induced RAW 264.7 cells	1600:1626	LPS induced RAW 264.7 cells	1600:1626	It clearly reveals the anti-oxidant and anti-inflammatory effect of HACF hydrogel scaffold on LPS induced RAW 264.7 cells.
33682617	5	31	theme	TNF-α	1038:1042	arg1	effects					903:909	The effects	899:909	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	31	theme	TNF-α	1038:1042	arg1	levels					1008:1013	the mRNA levels	999:1013	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	7	32	theme	anti-oxidant	1393:1404	arg1	capacity					1406:1413	a strong anti-oxidant capacity	1384:1413	a strong anti-oxidant capacity to inhibit inflammation associated gene expression by suppressing NF-kB signaling pathway	1384:1503	Hence, our results confirm that HACF has a strong anti-oxidant capacity to inhibit inflammation associated gene expression by suppressing NF-kB signaling pathway.
33682617	3	33	theme	tissue	479:484	arg1	engineering					486:496	cartilage tissue engineering	469:496	cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats	469:662	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	0	34	theme	In	0:1	arg1	potential					27:35	In vitro anti-inflammatory potential	0:35	In vitro anti-inflammatory potential of marine macromolecules	0:60	In vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications.
33682617	4	35	from	HACF	848:851	arg1	cells					892:896	LPS stimulated RAW 264.7 macrophage cells	856:896	LPS stimulated RAW 264.7 macrophage cells	856:896	Here we studied in vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells.
33682617	5	36	theme	NF-κB	1018:1022	arg1	effects					903:909	The effects	899:909	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	36	theme	NF-κB	1018:1022	arg1	levels					1008:1013	the mRNA levels	999:1013	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	3	37	theme	occurring	416:424	arg1	biopolymers					426:436	Naturally occurring biopolymers	406:436	Naturally occurring biopolymers as scaffolds	406:449	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	4	38	theme	LPS	856:858	arg1	cells					892:896	LPS stimulated RAW 264.7 macrophage cells	856:896	LPS stimulated RAW 264.7 macrophage cells	856:896	Here we studied in vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells.
33682617	0	39	theme	anti-inflammatory	9:25	arg1	potential					27:35	In vitro anti-inflammatory potential	0:35	In vitro anti-inflammatory potential of marine macromolecules	0:60	In vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications.
33682617	3	40	theme	plasticity	604:613	arg1	toxicity					564:571	anti-inflammatory, biocompatibility, biodegradability, low toxicity	505:571	toxicity	564:571	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	5	41	theme	iNOS	1025:1028	arg1	effects					903:909	The effects	899:909	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	41	theme	iNOS	1025:1028	arg1	levels					1008:1013	the mRNA levels	999:1013	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	3	42	theme	anti-inflammatory	505:521	arg1	toxicity					564:571	anti-inflammatory, biocompatibility, biodegradability, low toxicity	505:571	toxicity	564:571	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	3	43	theme	low	560:562	arg1	toxicity					564:571	anti-inflammatory, biocompatibility, biodegradability, low toxicity	505:571	toxicity	564:571	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	0	44	theme	macromolecules	47:60	arg1	potential					27:35	In vitro anti-inflammatory potential	0:35	In vitro anti-inflammatory potential of marine macromolecules	0:60	In vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications.
33682617	5	45	theme	IL-1β	1045:1049	arg1	effects					903:909	The effects	899:909	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	45	theme	IL-1β	1045:1049	arg1	levels					1008:1013	the mRNA levels	999:1013	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	3	46	theme	by-products	588:598	arg1	toxicity					564:571	anti-inflammatory, biocompatibility, biodegradability, low toxicity	505:571	toxicity	564:571	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	5	47	theme	IL-6	1055:1058	arg1	effects					903:909	The effects	899:909	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	47	theme	IL-6	1055:1058	arg1	levels					1008:1013	the mRNA levels	999:1013	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	6	48	theme	hydrogel	1147:1154	arg1	scaffold					1156:1163	HACF hydrogel scaffold	1142:1163	HACF hydrogel scaffold	1142:1163	The results revealed that HACF hydrogel scaffold exerts anti-inflammatory effect by inhibiting the production of ROS, suppress NF-kB translocation to the nucleus and thereby inhibiting the production of inflammatory mediators.
33682617	4	49	theme	anti-inflammatory	690:706	arg1	potential					708:716	in vitro anti-inflammatory potential	681:716	in vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells	681:896	Here we studied in vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells.
33682617	2	50	theme	matrix	334:339	arg1	framework					300:308	architectural framework	286:308	architectural framework of native extracellular matrix so as to encourage cell growth and eventual tissue regeneration	286:403	They are designed to provide architectural framework of native extracellular matrix so as to encourage cell growth and eventual tissue regeneration.
33682617	2	51	theme	eventual	376:383	arg1	regeneration					392:403	eventual tissue regeneration	376:403	eventual tissue regeneration	376:403	They are designed to provide architectural framework of native extracellular matrix so as to encourage cell growth and eventual tissue regeneration.
33682617	6	52	theme	mediators	1332:1340	arg1	production					1305:1314	the production	1301:1314	the production of inflammatory mediators	1301:1340	The results revealed that HACF hydrogel scaffold exerts anti-inflammatory effect by inhibiting the production of ROS, suppress NF-kB translocation to the nucleus and thereby inhibiting the production of inflammatory mediators.
33682617	2	53	theme	native	313:318	arg1	matrix					334:339	native extracellular matrix	313:339	native extracellular matrix	313:339	They are designed to provide architectural framework of native extracellular matrix so as to encourage cell growth and eventual tissue regeneration.
33682617	6	54	theme	ROS	1229:1231	arg1	production					1215:1224	the production	1211:1224	the production of ROS	1211:1231	The results revealed that HACF hydrogel scaffold exerts anti-inflammatory effect by inhibiting the production of ROS, suppress NF-kB translocation to the nucleus and thereby inhibiting the production of inflammatory mediators.
33682617	4	55	theme	bio-composite	756:768	arg1	scaffold					770:777	bio-composite scaffold	756:777	bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells	756:896	Here we studied in vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells.
33682617	3	56	from	toxicity	564:571	arg1	processing					618:627	processing	618:627	processing into a variety of material formats	618:662	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	8	57	theme	anti-oxidant	1529:1540	arg1	effect					1564:1569	the anti-oxidant and anti-inflammatory effect	1525:1569	the anti-oxidant and anti-inflammatory effect of HACF hydrogel scaffold on LPS induced RAW 264.7 cells	1525:1626	It clearly reveals the anti-oxidant and anti-inflammatory effect of HACF hydrogel scaffold on LPS induced RAW 264.7 cells.
33682617	7	58	theme	NF-kB	1481:1485	arg1	pathway					1497:1503	NF-kB signaling pathway	1481:1503	NF-kB signaling pathway	1481:1503	Hence, our results confirm that HACF has a strong anti-oxidant capacity to inhibit inflammation associated gene expression by suppressing NF-kB signaling pathway.
33682617	0	59	theme	tissue	157:162	arg1	applications					176:187	cartilage tissue engineering applications	147:187	cartilage tissue engineering applications	147:187	In vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications.
33682617	5	60	theme	RAW264.7	939:946	arg1	cells					948:952	RAW264.7 cells	939:952	RAW264.7 cells	939:952	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	0	61	from	scaffold	89:96	arg1	cells					137:141	LPS stimulated RAW 264.7 macrophage cells	101:141	LPS stimulated RAW 264.7 macrophage cells	101:141	In vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications.
33682617	4	62	theme	macromolecules	728:741	arg1	potential					708:716	in vitro anti-inflammatory potential	681:716	in vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells	681:896	Here we studied in vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells.
33682617	3	63	theme	formats	656:662	arg1	variety					636:642	a variety	634:642	a variety of material formats	634:662	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	3	63	theme	formats	656:662	arg1	formats					656:662	material formats	647:662	material formats	647:662	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	7	64	theme	gene	1450:1453	arg1	expression					1455:1464	inflammation associated gene expression	1426:1464	inflammation associated gene expression	1426:1464	Hence, our results confirm that HACF has a strong anti-oxidant capacity to inhibit inflammation associated gene expression by suppressing NF-kB signaling pathway.
33682617	7	65	contain	has	1380:1382	arg2	capacity					1406:1413	a strong anti-oxidant capacity	1384:1413	a strong anti-oxidant capacity to inhibit inflammation associated gene expression by suppressing NF-kB signaling pathway	1384:1503	Hence, our results confirm that HACF has a strong anti-oxidant capacity to inhibit inflammation associated gene expression by suppressing NF-kB signaling pathway.
33682617	7	65	contain	has	1380:1382	arg1	HACF					1375:1378	HACF	1375:1378	HACF	1375:1378	Hence, our results confirm that HACF has a strong anti-oxidant capacity to inhibit inflammation associated gene expression by suppressing NF-kB signaling pathway.
33682617	5	66	theme	mRNA	1003:1006	arg1	levels					1008:1013	the mRNA levels	999:1013	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6	899:1058	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	8	67	theme	hydrogel	1579:1586	arg1	scaffold					1588:1595	HACF hydrogel scaffold	1574:1595	HACF hydrogel scaffold	1574:1595	It clearly reveals the anti-oxidant and anti-inflammatory effect of HACF hydrogel scaffold on LPS induced RAW 264.7 cells.
33682617	7	68	theme	inflammation	1426:1437	arg1	expression					1455:1464	inflammation associated gene expression	1426:1464	inflammation associated gene expression	1426:1464	Hence, our results confirm that HACF has a strong anti-oxidant capacity to inhibit inflammation associated gene expression by suppressing NF-kB signaling pathway.
33682617	5	69	theme	intracellular	970:982	arg1	viability					926:934	the viability	922:934	the viability of RAW264.7 cells	922:952	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	69	theme	intracellular	970:982	arg1	ROS					984:986	intracellular ROS	970:986	intracellular ROS	970:986	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	3	70	from	plasticity	604:613	arg1	processing					618:627	processing	618:627	processing into a variety of material formats	618:662	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	5	71	from	effects	903:909	arg1	viability					926:934	the viability	922:934	the viability of RAW264.7 cells	922:952	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	71	from	effects	903:909	arg1	level					963:967	nitrite level	955:967	nitrite level	955:967	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	71	from	effects	903:909	arg1	ROS					984:986	intracellular ROS	970:986	intracellular ROS	970:986	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	8	72	theme	induced	1604:1610	arg1	cells					1622:1626	LPS induced RAW 264.7 cells	1600:1626	LPS induced RAW 264.7 cells	1600:1626	It clearly reveals the anti-oxidant and anti-inflammatory effect of HACF hydrogel scaffold on LPS induced RAW 264.7 cells.
33682617	3	73	from	processing	618:627	arg1	toxicity					564:571	anti-inflammatory, biocompatibility, biodegradability, low toxicity	505:571	toxicity	564:571	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	0	74	theme	RAW	116:118	arg1	cells					137:141	LPS stimulated RAW 264.7 macrophage cells	101:141	LPS stimulated RAW 264.7 macrophage cells	101:141	In vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications.
33682617	4	75	theme	stimulated	860:869	arg1	cells					892:896	LPS stimulated RAW 264.7 macrophage cells	856:896	LPS stimulated RAW 264.7 macrophage cells	856:896	Here we studied in vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells.
33682617	0	76	theme	macrophage	126:135	arg1	cells					137:141	LPS stimulated RAW 264.7 macrophage cells	101:141	LPS stimulated RAW 264.7 macrophage cells	101:141	In vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications.
33682617	7	77	theme	strong	1386:1391	arg1	capacity					1406:1413	a strong anti-oxidant capacity	1384:1413	a strong anti-oxidant capacity to inhibit inflammation associated gene expression by suppressing NF-kB signaling pathway	1384:1503	Hence, our results confirm that HACF has a strong anti-oxidant capacity to inhibit inflammation associated gene expression by suppressing NF-kB signaling pathway.
33682617	5	78	from	levels	1008:1013	arg1	viability					926:934	the viability	922:934	the viability of RAW264.7 cells	922:952	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	78	from	levels	1008:1013	arg1	level					963:967	nitrite level	955:967	nitrite level	955:967	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	5	78	from	levels	1008:1013	arg1	ROS					984:986	intracellular ROS	970:986	intracellular ROS	970:986	The effects of HACF on the viability of RAW264.7 cells, nitrite level, intracellular ROS as well as the mRNA levels of NF-κB, iNOS, COX-2, TNF-α, IL-1β and IL-6 were examined in LPS induced RAW264.7 macrophage cells.
33682617	0	79	theme	marine	40:45	arg1	macromolecules					47:60	marine macromolecules	40:60	marine macromolecules	40:60	In vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications.
33682617	1	80	theme	tissue	237:242	arg1	engineering					244:254	tissue engineering	237:254	tissue engineering	237:254	Biomaterials serve as an integral component of tissue engineering.
33682617	3	81	theme	cartilage	469:477	arg1	engineering					486:496	cartilage tissue engineering	469:496	cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats	469:662	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	8	82	theme	anti-inflammatory	1546:1562	arg1	effect					1564:1569	the anti-oxidant and anti-inflammatory effect	1525:1569	the anti-oxidant and anti-inflammatory effect of HACF hydrogel scaffold on LPS induced RAW 264.7 cells	1525:1626	It clearly reveals the anti-oxidant and anti-inflammatory effect of HACF hydrogel scaffold on LPS induced RAW 264.7 cells.
33682617	0	83	dep	In	0:1	arg1	vitro					3:7	vitro	3:7	vitro	3:7	In vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold on LPS stimulated RAW 264.7 macrophage cells for cartilage tissue engineering applications.
33682617	6	84	theme	anti-inflammatory	1172:1188	arg1	effect					1190:1195	anti-inflammatory effect	1172:1195	anti-inflammatory effect	1172:1195	The results revealed that HACF hydrogel scaffold exerts anti-inflammatory effect by inhibiting the production of ROS, suppress NF-kB translocation to the nucleus and thereby inhibiting the production of inflammatory mediators.
33682617	4	85	theme	in vitro	681:688	arg1	potential					708:716	in vitro anti-inflammatory potential	681:716	in vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells	681:896	Here we studied in vitro anti-inflammatory potential of marine macromolecules cross-linked bio-composite scaffold composed of hydroxyapatite, alginate, chitosan and fucoidan named as HACF on LPS stimulated RAW 264.7 macrophage cells.
33682617	3	86	dep	toxicity	564:571	arg1	biodegradability					542:557	anti-inflammatory, biocompatibility, biodegradability, low toxicity	505:571	biodegradability	542:557	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	3	86	dep	toxicity	564:571	arg1	biocompatibility					524:539	anti-inflammatory, biocompatibility, biodegradability, low toxicity	505:571	biocompatibility	524:539	Naturally occurring biopolymers as scaffolds offer options for cartilage tissue engineering due to anti-inflammatory, biocompatibility, biodegradability, low toxicity of degradation by-products and plasticity in processing into a variety of material formats.
33682617	2	87	theme	cell	360:363	arg1	growth					365:370	cell growth	360:370	cell growth	360:370	They are designed to provide architectural framework of native extracellular matrix so as to encourage cell growth and eventual tissue regeneration.
33682617	1	88	theme	engineering	244:254	arg1	component					224:232	an integral component	212:232	an integral component of tissue engineering	212:254	Biomaterials serve as an integral component of tissue engineering.
33682617	1	88	theme	engineering	244:254	arg1	Biomaterials					190:201	Biomaterials	190:201	Biomaterials	190:201	Biomaterials serve as an integral component of tissue engineering.
33470978	2	0	theme	used	356:359	arg1	precursors					371:380	commonly used elastomer precursors	347:380	commonly used elastomer precursors	347:380	However, the use of sliding cross-linkers has been constrained by their low miscibility with commonly used elastomer precursors and the specialized curing chemistries that are necessary for incorporating them into networks.
33470978	1	1	from	use	156:158	arg1	actuators					184:192	dielectric elastomer actuators	163:192	dielectric elastomer actuators due to their intrinsically soft nature and high elasticity	163:251	Slide-ring elastomers have garnered a lot of interest for their potential use in dielectric elastomer actuators due to their intrinsically soft nature and high elasticity.
33470978	4	2	theme	novel	719:723	arg1	cross-linkers					725:737	these novel cross-linkers	713:737	these novel cross-linkers	713:737	The sliding silicone films that were fabricated with these novel cross-linkers were highly extensible (>350%) and did not exhibit strain hardening even at high elongation.
33470978	5	3	theme	elastomers	914:923	arg1	loss					967:970	the characteristic low dielectric loss	933:970	the characteristic low dielectric loss	933:970	The composite films also retained the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss.
33470978	5	3	theme	elastomers	914:923	arg1	properties					891:900	the favorable dielectric properties	866:900	the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss	866:970	The composite films also retained the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss.
33470978	2	4	theme	cross-linkers	282:294	arg1	use					267:269	the use	263:269	the use of sliding cross-linkers	263:294	However, the use of sliding cross-linkers has been constrained by their low miscibility with commonly used elastomer precursors and the specialized curing chemistries that are necessary for incorporating them into networks.
33470978	2	5	theme	sliding	274:280	arg1	cross-linkers					282:294	sliding cross-linkers	274:294	sliding cross-linkers	274:294	However, the use of sliding cross-linkers has been constrained by their low miscibility with commonly used elastomer precursors and the specialized curing chemistries that are necessary for incorporating them into networks.
33470978	5	6	theme	favorable	870:878	arg1	loss					967:970	the characteristic low dielectric loss	933:970	the characteristic low dielectric loss	933:970	The composite films also retained the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss.
33470978	5	6	theme	favorable	870:878	arg1	properties					891:900	the favorable dielectric properties	866:900	the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss	866:970	The composite films also retained the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss.
33470978	3	7	theme	functional	528:537	arg1	cross-linkers					552:564	vinyl functional polyrotaxane cross-linkers	522:564	vinyl functional polyrotaxane cross-linkers that are compatible with polysiloxanes and can be processed by industrially scalable methods	522:657	Here, we have presented a method to produce vinyl functional polyrotaxane cross-linkers that are compatible with polysiloxanes and can be processed by industrially scalable methods.
33470978	5	8	theme	low	952:954	arg1	loss					967:970	the characteristic low dielectric loss	933:970	the characteristic low dielectric loss	933:970	The composite films also retained the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss.
33470978	1	9	theme	dielectric	163:172	arg1	actuators					184:192	dielectric elastomer actuators	163:192	dielectric elastomer actuators due to their intrinsically soft nature and high elasticity	163:251	Slide-ring elastomers have garnered a lot of interest for their potential use in dielectric elastomer actuators due to their intrinsically soft nature and high elasticity.
33470978	1	10	theme	Slide-ring	82:91	arg1	elastomers					93:102	Slide-ring elastomers	82:102	Slide-ring elastomers	82:102	Slide-ring elastomers have garnered a lot of interest for their potential use in dielectric elastomer actuators due to their intrinsically soft nature and high elasticity.
33470978	2	11	theme	specialized	390:400	arg1	chemistries					409:419	the specialized curing chemistries	386:419	the specialized curing chemistries	386:419	However, the use of sliding cross-linkers has been constrained by their low miscibility with commonly used elastomer precursors and the specialized curing chemistries that are necessary for incorporating them into networks.
33470978	2	11	theme	specialized	390:400	arg1	necessary					430:438	necessary	430:438	necessary	430:438	However, the use of sliding cross-linkers has been constrained by their low miscibility with commonly used elastomer precursors and the specialized curing chemistries that are necessary for incorporating them into networks.
33470978	3	12	theme	vinyl	522:526	arg1	cross-linkers					552:564	vinyl functional polyrotaxane cross-linkers	522:564	vinyl functional polyrotaxane cross-linkers that are compatible with polysiloxanes and can be processed by industrially scalable methods	522:657	Here, we have presented a method to produce vinyl functional polyrotaxane cross-linkers that are compatible with polysiloxanes and can be processed by industrially scalable methods.
33470978	0	13	theme	Novel	0:4	arg1	polyrotaxane					6:17	Novel polyrotaxane	0:17	Novel polyrotaxane	0:17	Novel polyrotaxane cross-linkers as a versatile platform for slide-ring silicone.
33470978	6	14	theme	robust	1010:1015	arg1	platform					1017:1024	a robust platform	1008:1024	a robust platform for producing a new class of sliding silicone elastomers with well-defined networks structures	1008:1119	The modified polyrotaxanes present a robust platform for producing a new class of sliding silicone elastomers with well-defined networks structures.
33470978	4	15	dep	extensible	751:760	arg1	extensible					751:760	extensible	751:760	extensible	751:760	The sliding silicone films that were fabricated with these novel cross-linkers were highly extensible (>350%) and did not exhibit strain hardening even at high elongation.
33470978	4	15	dep	extensible	751:760	arg1	%					767:767	>350%	763:767	>350%	763:767	The sliding silicone films that were fabricated with these novel cross-linkers were highly extensible (>350%) and did not exhibit strain hardening even at high elongation.
33470978	4	15	dep	extensible	751:760	arg1	films					681:685	The sliding silicone films	660:685	The sliding silicone films that were fabricated with these novel cross-linkers	660:737	The sliding silicone films that were fabricated with these novel cross-linkers were highly extensible (>350%) and did not exhibit strain hardening even at high elongation.
33470978	1	16	theme	due	194:196	arg1	actuators					184:192	dielectric elastomer actuators	163:192	dielectric elastomer actuators due to their intrinsically soft nature and high elasticity	163:251	Slide-ring elastomers have garnered a lot of interest for their potential use in dielectric elastomer actuators due to their intrinsically soft nature and high elasticity.
33470978	5	17	theme	dielectric	956:965	arg1	loss					967:970	the characteristic low dielectric loss	933:970	the characteristic low dielectric loss	933:970	The composite films also retained the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss.
33470978	6	18	theme	elastomers	1072:1081	arg1	class					1046:1050	a new class	1040:1050	a new class of sliding silicone elastomers with well-defined networks structures	1040:1119	The modified polyrotaxanes present a robust platform for producing a new class of sliding silicone elastomers with well-defined networks structures.
33470978	6	19	theme	well-defined	1088:1099	arg1	networks					1101:1108	well-defined networks	1088:1108	well-defined networks	1088:1108	The modified polyrotaxanes present a robust platform for producing a new class of sliding silicone elastomers with well-defined networks structures.
33470978	5	20	theme	composite	836:844	arg1	films					846:850	The composite films	832:850	The composite films	832:850	The composite films also retained the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss.
33470978	4	21	theme	strain	790:795	arg1	hardening					797:805	strain hardening	790:805	strain hardening	790:805	The sliding silicone films that were fabricated with these novel cross-linkers were highly extensible (>350%) and did not exhibit strain hardening even at high elongation.
33470978	5	22	theme	dielectric	880:889	arg1	loss					967:970	the characteristic low dielectric loss	933:970	the characteristic low dielectric loss	933:970	The composite films also retained the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss.
33470978	5	22	theme	dielectric	880:889	arg1	properties					891:900	the favorable dielectric properties	866:900	the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss	866:970	The composite films also retained the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss.
33470978	0	23	theme	versatile	38:46	arg1	platform					48:55	a versatile platform	36:55	a versatile platform for slide-ring silicone	36:79	Novel polyrotaxane cross-linkers as a versatile platform for slide-ring silicone.
33470978	3	24	with	compatible	575:584	arg1	polysiloxanes					591:603	polysiloxanes	591:603	polysiloxanes	591:603	Here, we have presented a method to produce vinyl functional polyrotaxane cross-linkers that are compatible with polysiloxanes and can be processed by industrially scalable methods.
33470978	4	25	theme	silicone	672:679	arg1	extensible					751:760	extensible	751:760	extensible	751:760	The sliding silicone films that were fabricated with these novel cross-linkers were highly extensible (>350%) and did not exhibit strain hardening even at high elongation.
33470978	4	25	theme	silicone	672:679	arg1	%					767:767	>350%	763:767	>350%	763:767	The sliding silicone films that were fabricated with these novel cross-linkers were highly extensible (>350%) and did not exhibit strain hardening even at high elongation.
33470978	4	25	theme	silicone	672:679	arg1	films					681:685	The sliding silicone films	660:685	The sliding silicone films that were fabricated with these novel cross-linkers	660:737	The sliding silicone films that were fabricated with these novel cross-linkers were highly extensible (>350%) and did not exhibit strain hardening even at high elongation.
33470978	2	26	theme	curing	402:407	arg1	chemistries					409:419	the specialized curing chemistries	386:419	the specialized curing chemistries	386:419	However, the use of sliding cross-linkers has been constrained by their low miscibility with commonly used elastomer precursors and the specialized curing chemistries that are necessary for incorporating them into networks.
33470978	2	26	theme	curing	402:407	arg1	necessary					430:438	necessary	430:438	necessary	430:438	However, the use of sliding cross-linkers has been constrained by their low miscibility with commonly used elastomer precursors and the specialized curing chemistries that are necessary for incorporating them into networks.
33470978	6	27	theme	modified	977:984	arg1	polyrotaxanes					986:998	The modified polyrotaxanes	973:998	The modified polyrotaxanes	973:998	The modified polyrotaxanes present a robust platform for producing a new class of sliding silicone elastomers with well-defined networks structures.
33470978	6	28	theme	class	1046:1050	arg1	structures					1110:1119	a new class of sliding silicone elastomers with well-defined networks structures	1040:1119	a new class of sliding silicone elastomers with well-defined networks structures	1040:1119	The modified polyrotaxanes present a robust platform for producing a new class of sliding silicone elastomers with well-defined networks structures.
33470978	1	29	theme	soft	221:224	arg1	nature					226:231	their intrinsically soft nature	201:231	their intrinsically soft nature	201:231	Slide-ring elastomers have garnered a lot of interest for their potential use in dielectric elastomer actuators due to their intrinsically soft nature and high elasticity.
33470978	6	30	theme	silicone	1063:1070	arg1	elastomers					1072:1081	sliding silicone elastomers	1055:1081	sliding silicone elastomers with well-defined networks	1055:1108	The modified polyrotaxanes present a robust platform for producing a new class of sliding silicone elastomers with well-defined networks structures.
33470978	2	31	with	miscibility	330:340	arg1	necessary					430:438	necessary	430:438	necessary	430:438	However, the use of sliding cross-linkers has been constrained by their low miscibility with commonly used elastomer precursors and the specialized curing chemistries that are necessary for incorporating them into networks.
33470978	2	31	with	miscibility	330:340	arg1	chemistries					409:419	the specialized curing chemistries	386:419	the specialized curing chemistries	386:419	However, the use of sliding cross-linkers has been constrained by their low miscibility with commonly used elastomer precursors and the specialized curing chemistries that are necessary for incorporating them into networks.
33470978	2	31	with	miscibility	330:340	arg1	precursors					371:380	commonly used elastomer precursors	347:380	commonly used elastomer precursors	347:380	However, the use of sliding cross-linkers has been constrained by their low miscibility with commonly used elastomer precursors and the specialized curing chemistries that are necessary for incorporating them into networks.
33470978	6	32	with	elastomers	1072:1081	arg1	networks					1101:1108	well-defined networks	1088:1108	well-defined networks	1088:1108	The modified polyrotaxanes present a robust platform for producing a new class of sliding silicone elastomers with well-defined networks structures.
33470978	5	33	theme	characteristic	937:950	arg1	loss					967:970	the characteristic low dielectric loss	933:970	the characteristic low dielectric loss	933:970	The composite films also retained the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss.
33470978	3	34	theme	scalable	642:649	arg1	methods					651:657	industrially scalable methods	629:657	industrially scalable methods	629:657	Here, we have presented a method to produce vinyl functional polyrotaxane cross-linkers that are compatible with polysiloxanes and can be processed by industrially scalable methods.
33470978	1	35	theme	interest	127:134	arg1	interest					127:134	interest	127:134	interest	127:134	Slide-ring elastomers have garnered a lot of interest for their potential use in dielectric elastomer actuators due to their intrinsically soft nature and high elasticity.
33470978	1	35	theme	interest	127:134	arg1	lot					120:122	a lot	118:122	a lot of interest for their potential use in dielectric elastomer actuators due to their intrinsically soft nature and high elasticity	118:251	Slide-ring elastomers have garnered a lot of interest for their potential use in dielectric elastomer actuators due to their intrinsically soft nature and high elasticity.
33470978	6	36	theme	sliding	1055:1061	arg1	elastomers					1072:1081	sliding silicone elastomers	1055:1081	sliding silicone elastomers with well-defined networks	1055:1108	The modified polyrotaxanes present a robust platform for producing a new class of sliding silicone elastomers with well-defined networks structures.
33470978	3	37	theme	polyrotaxane	539:550	arg1	cross-linkers					552:564	vinyl functional polyrotaxane cross-linkers	522:564	vinyl functional polyrotaxane cross-linkers that are compatible with polysiloxanes and can be processed by industrially scalable methods	522:657	Here, we have presented a method to produce vinyl functional polyrotaxane cross-linkers that are compatible with polysiloxanes and can be processed by industrially scalable methods.
33470978	1	38	theme	potential	146:154	arg1	use					156:158	their potential use	140:158	their potential use in dielectric elastomer actuators due to their intrinsically soft nature and high elasticity	140:251	Slide-ring elastomers have garnered a lot of interest for their potential use in dielectric elastomer actuators due to their intrinsically soft nature and high elasticity.
33470978	2	39	theme	low	326:328	arg1	miscibility					330:340	their low miscibility	320:340	their low miscibility with commonly used elastomer precursors and the specialized curing chemistries that are necessary for incorporating them into networks	320:475	However, the use of sliding cross-linkers has been constrained by their low miscibility with commonly used elastomer precursors and the specialized curing chemistries that are necessary for incorporating them into networks.
33470978	4	40	theme	sliding	664:670	arg1	extensible					751:760	extensible	751:760	extensible	751:760	The sliding silicone films that were fabricated with these novel cross-linkers were highly extensible (>350%) and did not exhibit strain hardening even at high elongation.
33470978	4	40	theme	sliding	664:670	arg1	%					767:767	>350%	763:767	>350%	763:767	The sliding silicone films that were fabricated with these novel cross-linkers were highly extensible (>350%) and did not exhibit strain hardening even at high elongation.
33470978	4	40	theme	sliding	664:670	arg1	films					681:685	The sliding silicone films	660:685	The sliding silicone films that were fabricated with these novel cross-linkers	660:737	The sliding silicone films that were fabricated with these novel cross-linkers were highly extensible (>350%) and did not exhibit strain hardening even at high elongation.
33470978	4	41	theme	high	815:818	arg1	elongation					820:829	high elongation	815:829	high elongation	815:829	The sliding silicone films that were fabricated with these novel cross-linkers were highly extensible (>350%) and did not exhibit strain hardening even at high elongation.
33470978	5	42	theme	silicone	905:912	arg1	elastomers					914:923	silicone elastomers	905:923	silicone elastomers	905:923	The composite films also retained the favorable dielectric properties of silicone elastomers such as the characteristic low dielectric loss.
33470978	1	43	theme	elastomer	174:182	arg1	actuators					184:192	dielectric elastomer actuators	163:192	dielectric elastomer actuators due to their intrinsically soft nature and high elasticity	163:251	Slide-ring elastomers have garnered a lot of interest for their potential use in dielectric elastomer actuators due to their intrinsically soft nature and high elasticity.
33470978	1	44	theme	high	237:240	arg1	elasticity					242:251	high elasticity	237:251	high elasticity	237:251	Slide-ring elastomers have garnered a lot of interest for their potential use in dielectric elastomer actuators due to their intrinsically soft nature and high elasticity.
33470978	0	45	theme	slide-ring	61:70	arg1	silicone					72:79	slide-ring silicone	61:79	slide-ring silicone	61:79	Novel polyrotaxane cross-linkers as a versatile platform for slide-ring silicone.
33470978	2	46	theme	elastomer	361:369	arg1	precursors					371:380	commonly used elastomer precursors	347:380	commonly used elastomer precursors	347:380	However, the use of sliding cross-linkers has been constrained by their low miscibility with commonly used elastomer precursors and the specialized curing chemistries that are necessary for incorporating them into networks.
33470978	6	47	theme	new	1042:1044	arg1	class					1046:1050	a new class	1040:1050	a new class of sliding silicone elastomers with well-defined networks structures	1040:1119	The modified polyrotaxanes present a robust platform for producing a new class of sliding silicone elastomers with well-defined networks structures.
33096654	7	0	theme	board	1394:1398	arg1	performance					1400:1410	the board performance	1390:1410	the board performance	1390:1410	Moreover, it was proven that when MFC is introduced into the adhesive resin system, there is a possibility of decreasing the resin consumption, by maintaining the board performance.
33096654	6	1	theme	prepared	1214:1221	arg1	resins					1223:1228	the already prepared resins	1202:1228	the already prepared resins	1202:1228	It was found that MFC improves not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement), especially when admixed with the already prepared resins.
33096654	7	2	theme	resin	1356:1360	arg1	consumption					1362:1372	the resin consumption	1352:1372	the resin consumption	1352:1372	Moreover, it was proven that when MFC is introduced into the adhesive resin system, there is a possibility of decreasing the resin consumption, by maintaining the board performance.
33096654	4	3	theme	non-renewable	684:696	arg1	compounds					707:715	conventional and non-renewable chemical compounds	667:715	conventional and non-renewable chemical compounds	667:715	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	0	4	theme	Panels	81:86	arg1	Production					56:65	the Production	52:65	the Production of Wood-Based Panels	52:86	Micro-Fibrillated Cellulose in Adhesive Systems for the Production of Wood-Based Panels.
33096654	9	5	theme	adhesive	1567:1574	arg1	producers					1576:1584	adhesive producers	1567:1584	adhesive producers	1567:1584	In addition, its natural origin can give adhesive producers the opportunity to move over to more environmentally friendly product solutions.
33096654	1	6	theme	additive	150:157	arg1	Cellulose					107:115	Micro-Fibrillated Cellulose	89:115	Micro-Fibrillated Cellulose (MFC)	89:121	Micro-Fibrillated Cellulose (MFC) is a new type of bio-based additive, coming from wood cellulose.
33096654	1	6	theme	additive	150:157	arg1	type					132:135	a new type	126:135	a new type	126:135	Micro-Fibrillated Cellulose (MFC) is a new type of bio-based additive, coming from wood cellulose.
33096654	6	7	dep	improvement	1159:1169	arg1	e.g.					1144:1147	e.g.	1144:1147	e.g.	1144:1147	It was found that MFC improves not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement), especially when admixed with the already prepared resins.
33096654	2	8	link	derived	222:228	arg1	chemicals					230:238	oil derived chemicals	218:238	oil derived chemicals in several application fields	218:268	It can compete and substitute oil derived chemicals in several application fields.
33096654	9	9	theme	natural	1543:1549	arg1	origin					1551:1556	its natural origin	1539:1556	its natural origin	1539:1556	In addition, its natural origin can give adhesive producers the opportunity to move over to more environmentally friendly product solutions.
33096654	6	10	theme	adhesive	1117:1124	arg1	colloids					1134:1141	the applied adhesive polymer colloids	1105:1141	the applied adhesive polymer colloids (e.g., rheology improvement)	1105:1170	It was found that MFC improves not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement), especially when admixed with the already prepared resins.
33096654	4	11	theme	strand	591:596	arg1	types					530:534	wood-based panel types	513:534	wood-based panel types such as particleboard	513:556	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	11	theme	strand	591:596	arg1	particleboard					544:556	particleboard	544:556	particleboard	544:556	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	11	theme	strand	591:596	arg1	board					598:602	waferboard or randomly-oriented strand board	559:602	waferboard or randomly-oriented strand board	559:602	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	3	12	theme	waterborne	335:344	arg1	systems					355:361	waterborne adhesive systems	335:361	waterborne adhesive systems applied in the manufacture of composite wood-based panels	335:419	In the present work, the use of micro-fibrillated cellulose, in waterborne adhesive systems applied in the manufacture of composite wood-based panels was evaluated.
33096654	6	13	theme	applied	1109:1115	arg1	colloids					1134:1141	the applied adhesive polymer colloids	1105:1141	the applied adhesive polymer colloids (e.g., rheology improvement)	1105:1170	It was found that MFC improves not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement), especially when admixed with the already prepared resins.
33096654	5	14	theme	MFC	931:933	arg1	suspension					938:947	MFC 2% suspension	931:947	MFC 2% suspension	931:947	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	4	15	theme	randomly-oriented	573:589	arg1	types					530:534	wood-based panel types	513:534	wood-based panel types such as particleboard	513:556	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	15	theme	randomly-oriented	573:589	arg1	particleboard					544:556	particleboard	544:556	particleboard	544:556	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	15	theme	randomly-oriented	573:589	arg1	board					598:602	waferboard or randomly-oriented strand board	559:602	waferboard or randomly-oriented strand board	559:602	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	3	16	theme	cellulose	321:329	arg1	use					296:298	the use	292:298	the use	292:298	In the present work, the use of micro-fibrillated cellulose, in waterborne adhesive systems applied in the manufacture of composite wood-based panels was evaluated.
33096654	6	17	theme	products	1070:1077	arg1	behaviour					1092:1100	the behaviour	1088:1100	not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement)	1021:1170	It was found that MFC improves not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement), especially when admixed with the already prepared resins.
33096654	6	17	theme	products	1070:1077	arg1	performance					1034:1044	the performance	1030:1044	not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement)	1021:1170	It was found that MFC improves not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement), especially when admixed with the already prepared resins.
33096654	7	18	theme	resin	1301:1305	arg1	system					1307:1312	the adhesive resin system	1288:1312	the adhesive resin system	1288:1312	Moreover, it was proven that when MFC is introduced into the adhesive resin system, there is a possibility of decreasing the resin consumption, by maintaining the board performance.
33096654	5	19	theme	resin	847:851	arg1	paste					872:876	MFC 10% paste	864:876	MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin	864:987	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	5	19	theme	resin	847:851	arg1	synthesis					853:861	the adhesive resin synthesis	834:861	the adhesive resin synthesis	834:861	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	2	20	theme	application	251:261	arg1	fields					263:268	several application fields	243:268	several application fields	243:268	It can compete and substitute oil derived chemicals in several application fields.
33096654	2	21	dep	derived	222:228	arg1	oil					218:220	oil	218:220	oil	218:220	It can compete and substitute oil derived chemicals in several application fields.
33096654	5	22	theme	adhesive	768:775	arg1	systems					777:783	the adhesive systems	764:783	the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin	764:987	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	8	23	theme	interesting	1477:1487	arg1	new					1489:1491	a highly interesting new	1468:1491	a highly interesting new additive for adhesive producers	1468:1523	MFC's robustness to pH, shear and temperature makes it a highly interesting new additive for adhesive producers.
33096654	9	24	theme	friendly	1639:1646	arg1	solutions					1656:1664	more environmentally friendly product solutions	1618:1664	more environmentally friendly product solutions	1618:1664	In addition, its natural origin can give adhesive producers the opportunity to move over to more environmentally friendly product solutions.
33096654	1	25	theme	Micro-Fibrillated	89:105	arg1	Cellulose					107:115	Micro-Fibrillated Cellulose	89:115	Micro-Fibrillated Cellulose (MFC)	89:121	Micro-Fibrillated Cellulose (MFC) is a new type of bio-based additive, coming from wood cellulose.
33096654	1	25	theme	Micro-Fibrillated	89:105	arg1	type					132:135	a new type	126:135	a new type	126:135	Micro-Fibrillated Cellulose (MFC) is a new type of bio-based additive, coming from wood cellulose.
33096654	1	25	theme	Micro-Fibrillated	89:105	arg1	MFC					118:120	MFC	118:120	MFC	118:120	Micro-Fibrillated Cellulose (MFC) is a new type of bio-based additive, coming from wood cellulose.
33096654	3	26	theme	wood-based	403:412	arg1	panels					414:419	composite wood-based panels	393:419	composite wood-based panels	393:419	In the present work, the use of micro-fibrillated cellulose, in waterborne adhesive systems applied in the manufacture of composite wood-based panels was evaluated.
33096654	5	27	theme	%	936:936	arg1	suspension					938:947	MFC 2% suspension	931:947	MFC 2% suspension	931:947	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	5	28	theme	adhesive	838:845	arg1	paste					872:876	MFC 10% paste	864:876	MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin	864:987	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	5	28	theme	adhesive	838:845	arg1	synthesis					853:861	the adhesive resin synthesis	834:861	the adhesive resin synthesis	834:861	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	2	29	from	chemicals	230:238	arg1	fields					263:268	several application fields	243:268	several application fields	243:268	It can compete and substitute oil derived chemicals in several application fields.
33096654	3	30	theme	panels	414:419	arg1	manufacture					378:388	the manufacture	374:388	the manufacture of composite wood-based panels	374:419	In the present work, the use of micro-fibrillated cellulose, in waterborne adhesive systems applied in the manufacture of composite wood-based panels was evaluated.
33096654	3	31	theme	adhesive	346:353	arg1	systems					355:361	waterborne adhesive systems	335:361	waterborne adhesive systems applied in the manufacture of composite wood-based panels	335:419	In the present work, the use of micro-fibrillated cellulose, in waterborne adhesive systems applied in the manufacture of composite wood-based panels was evaluated.
33096654	5	32	theme	adhesive	912:919	arg1	resin					921:925	the already prepared adhesive resin	891:925	the already prepared adhesive resin	891:925	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	5	33	theme	%	808:808	arg1	suspension					810:819	MFC 2% suspension	803:819	MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin	803:987	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	5	34	theme	2	807:807	arg1	%					808:808	%	808:808	%	808:808	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	5	35	theme	prepared	903:910	arg1	resin					921:925	the already prepared adhesive resin	891:925	the already prepared adhesive resin	891:925	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	6	36	theme	polymer	1126:1132	arg1	colloids					1134:1141	the applied adhesive polymer colloids	1105:1141	the applied adhesive polymer colloids (e.g., rheology improvement)	1105:1170	It was found that MFC improves not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement), especially when admixed with the already prepared resins.
33096654	5	37	theme	%	870:870	arg1	paste					872:876	MFC 10% paste	864:876	MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin	864:987	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	5	37	theme	%	870:870	arg1	synthesis					853:861	the adhesive resin synthesis	834:861	the adhesive resin synthesis	834:861	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	6	38	theme	panel	1064:1068	arg1	products					1070:1077	the final wood panel products	1049:1077	the final wood panel products	1049:1077	It was found that MFC improves not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement), especially when admixed with the already prepared resins.
33096654	7	39	theme	adhesive	1292:1299	arg1	system					1307:1312	the adhesive resin system	1288:1312	the adhesive resin system	1288:1312	Moreover, it was proven that when MFC is introduced into the adhesive resin system, there is a possibility of decreasing the resin consumption, by maintaining the board performance.
33096654	1	40	theme	wood	172:175	arg1	cellulose					177:185	wood cellulose	172:185	wood cellulose	172:185	Micro-Fibrillated Cellulose (MFC) is a new type of bio-based additive, coming from wood cellulose.
33096654	3	41	theme	composite	393:401	arg1	panels					414:419	composite wood-based panels	393:419	composite wood-based panels	393:419	In the present work, the use of micro-fibrillated cellulose, in waterborne adhesive systems applied in the manufacture of composite wood-based panels was evaluated.
33096654	4	42	theme	wood-based	513:522	arg1	particleboard					544:556	particleboard	544:556	particleboard	544:556	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	42	theme	wood-based	513:522	arg1	types					530:534	wood-based panel types	513:534	wood-based panel types such as particleboard	513:556	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	42	theme	wood-based	513:522	arg1	plywood					608:614	plywood	608:614	plywood	608:614	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	42	theme	wood-based	513:522	arg1	board					598:602	waferboard or randomly-oriented strand board	559:602	waferboard or randomly-oriented strand board	559:602	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	43	theme	waferboard	559:568	arg1	types					530:534	wood-based panel types	513:534	wood-based panel types such as particleboard	513:556	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	43	theme	waferboard	559:568	arg1	particleboard					544:556	particleboard	544:556	particleboard	544:556	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	43	theme	waferboard	559:568	arg1	board					598:602	waferboard or randomly-oriented strand board	559:602	waferboard or randomly-oriented strand board	559:602	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	0	44	theme	Adhesive	31:38	arg1	Systems					40:46	Adhesive Systems	31:46	Adhesive Systems for the Production of Wood-Based Panels	31:86	Micro-Fibrillated Cellulose in Adhesive Systems for the Production of Wood-Based Panels.
33096654	5	45	theme	MFC	803:805	arg1	suspension					810:819	MFC 2% suspension	803:819	MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin	803:987	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	9	46	theme	environmentally	1623:1637	arg1	solutions					1656:1664	more environmentally friendly product solutions	1618:1664	more environmentally friendly product solutions	1618:1664	In addition, its natural origin can give adhesive producers the opportunity to move over to more environmentally friendly product solutions.
33096654	9	47	theme	product	1648:1654	arg1	solutions					1656:1664	more environmentally friendly product solutions	1618:1664	more environmentally friendly product solutions	1618:1664	In addition, its natural origin can give adhesive producers the opportunity to move over to more environmentally friendly product solutions.
33096654	6	48	theme	rheology	1150:1157	arg1	improvement					1159:1169	rheology improvement	1150:1169	rheology improvement	1150:1169	It was found that MFC improves not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement), especially when admixed with the already prepared resins.
33096654	4	49	theme	compounds	707:715	arg1	application					624:634	the application	620:634	the application of MFC	620:641	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	49	theme	compounds	707:715	arg1	substitution					651:662	the substitution	647:662	the substitution of conventional and non-renewable chemical compounds	647:715	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	50	theme	types	530:534	arg1	performance					498:508	the performance	494:508	the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood,	494:615	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	5	51	dep	suspension	810:819	arg1	i.e.					797:800	i.e.	797:800	i.e.	797:800	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	4	52	theme	chemical	698:705	arg1	compounds					707:715	conventional and non-renewable chemical compounds	667:715	conventional and non-renewable chemical compounds	667:715	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	53	theme	panel	524:528	arg1	particleboard					544:556	particleboard	544:556	particleboard	544:556	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	53	theme	panel	524:528	arg1	types					530:534	wood-based panel types	513:534	wood-based panel types such as particleboard	513:556	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	53	theme	panel	524:528	arg1	plywood					608:614	plywood	608:614	plywood	608:614	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	53	theme	panel	524:528	arg1	board					598:602	waferboard or randomly-oriented strand board	559:602	waferboard or randomly-oriented strand board	559:602	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	3	54	from	use	296:298	arg1	systems					355:361	waterborne adhesive systems	335:361	waterborne adhesive systems applied in the manufacture of composite wood-based panels	335:419	In the present work, the use of micro-fibrillated cellulose, in waterborne adhesive systems applied in the manufacture of composite wood-based panels was evaluated.
33096654	2	55	theme	several	243:249	arg1	fields					263:268	several application fields	243:268	several application fields	243:268	It can compete and substitute oil derived chemicals in several application fields.
33096654	5	56	theme	prepared	974:981	arg1	resin					983:987	the already prepared resin	962:987	the already prepared resin	962:987	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	6	57	theme	wood	1059:1062	arg1	products					1070:1077	the final wood panel products	1049:1077	the final wood panel products	1049:1077	It was found that MFC improves not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement), especially when admixed with the already prepared resins.
33096654	6	58	theme	final	1053:1057	arg1	products					1070:1077	the final wood panel products	1049:1077	the final wood panel products	1049:1077	It was found that MFC improves not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement), especially when admixed with the already prepared resins.
33096654	8	59	theme	additive	1493:1500	arg1	new					1489:1491	a highly interesting new	1468:1491	a highly interesting new additive for adhesive producers	1468:1523	MFC's robustness to pH, shear and temperature makes it a highly interesting new additive for adhesive producers.
33096654	3	60	theme	present	278:284	arg1	work					286:289	the present work	274:289	the present work	274:289	In the present work, the use of micro-fibrillated cellulose, in waterborne adhesive systems applied in the manufacture of composite wood-based panels was evaluated.
33096654	1	61	theme	new	128:130	arg1	Cellulose					107:115	Micro-Fibrillated Cellulose	89:115	Micro-Fibrillated Cellulose (MFC)	89:121	Micro-Fibrillated Cellulose (MFC) is a new type of bio-based additive, coming from wood cellulose.
33096654	1	61	theme	new	128:130	arg1	type					132:135	a new type	126:135	a new type	126:135	Micro-Fibrillated Cellulose (MFC) is a new type of bio-based additive, coming from wood cellulose.
33096654	0	62	theme	Wood-Based	70:79	arg1	Panels					81:86	Wood-Based Panels	70:86	Wood-Based Panels	70:86	Micro-Fibrillated Cellulose in Adhesive Systems for the Production of Wood-Based Panels.
33096654	6	63	theme	colloids	1134:1141	arg1	behaviour					1092:1100	the behaviour	1088:1100	not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement)	1021:1170	It was found that MFC improves not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement), especially when admixed with the already prepared resins.
33096654	6	63	theme	colloids	1134:1141	arg1	performance					1034:1044	the performance	1030:1044	not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement)	1021:1170	It was found that MFC improves not only the performance of the final wood panel products but also the behaviour of the applied adhesive polymer colloids (e.g., rheology improvement), especially when admixed with the already prepared resins.
33096654	4	64	theme	conventional	667:678	arg1	compounds					707:715	conventional and non-renewable chemical compounds	667:715	conventional and non-renewable chemical compounds	667:715	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	65	theme	MFC	639:641	arg1	application					624:634	the application	620:634	the application of MFC	620:641	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	4	65	theme	MFC	639:641	arg1	substitution					651:662	the substitution	647:662	the substitution of conventional and non-renewable chemical compounds	647:715	Research was conducted to test the potential of improving the performance of wood-based panel types such as particleboard, waferboard or randomly-oriented strand board and plywood, by the application of MFC and the substitution of conventional and non-renewable chemical compounds.
33096654	8	66	theme	adhesive	1506:1513	arg1	producers					1515:1523	adhesive producers	1506:1523	adhesive producers	1506:1523	MFC's robustness to pH, shear and temperature makes it a highly interesting new additive for adhesive producers.
33096654	3	67	theme	micro-fibrillated	303:319	arg1	cellulose					321:329	micro-fibrillated cellulose	303:329	micro-fibrillated cellulose	303:329	In the present work, the use of micro-fibrillated cellulose, in waterborne adhesive systems applied in the manufacture of composite wood-based panels was evaluated.
33096654	2	68	theme	derived	222:228	arg1	chemicals					230:238	oil derived chemicals	218:238	oil derived chemicals in several application fields	218:268	It can compete and substitute oil derived chemicals in several application fields.
33096654	5	69	theme	MFC	864:866	arg1	paste					872:876	MFC 10% paste	864:876	MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin	864:987	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33096654	5	69	theme	MFC	864:866	arg1	synthesis					853:861	the adhesive resin synthesis	834:861	the adhesive resin synthesis	834:861	The approaches followed to introduce MFC into the adhesive systems were three, i.e., MFC 2% suspension added during the adhesive resin synthesis, MFC 10% paste admixed with the already prepared adhesive resin and MFC 2% suspension admixed with the already prepared resin.
33529737	0	0	theme	non-pathogenic	88:101	arg1	serogroups					103:112	pathogenic and non-pathogenic serogroups	73:112	pathogenic and non-pathogenic serogroups	73:112	Biochemical analysis of leptospiral LPS explained the difference between pathogenic and non-pathogenic serogroups.
33529737	3	1	theme	chemical	304:311	arg1	analysis					325:332	the chemical composition analysis	300:332	the chemical composition analysis of leptospiral lipopolysaccharides (LPS) extracted from 5 pathogenic serovars like Autumnalis, Australis, Ballum, Grippotyphosa, Pomona, and the nonpathogenic serovar Andamana	300:508	Also, the chemical composition analysis of leptospiral lipopolysaccharides (LPS) extracted from 5 pathogenic serovars like Autumnalis, Australis, Ballum, Grippotyphosa, Pomona, and the nonpathogenic serovar Andamana was performed.
33529737	10	2	theme	methyl	1400:1405	arg1	Autumnalis					1417:1426	Autumnalis	1417:1426	Autumnalis	1417:1426	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	2	theme	methyl	1400:1405	arg1	groups					1407:1412	methyl groups	1400:1412	methyl groups of Autumnalis, Australis, and Ballum	1400:1449	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	2	theme	methyl	1400:1405	arg1	Australis					1429:1437	Australis	1429:1437	Australis	1429:1437	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	2	theme	methyl	1400:1405	arg1	Ballum					1444:1449	Ballum	1444:1449	Ballum	1444:1449	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	8	3	located	present	1175:1181	arg1	Andamana					1186:1193	Andamana	1186:1193	Andamana	1186:1193	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	8	3	located	present	1175:1181	arg2	acid					1157:1160	stearic acid	1149:1160	stearic acid (C18:0)	1149:1168	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	8	3	located	present	1175:1181	arg2	acid					1132:1135	myristoleic acid	1120:1135	myristoleic acid (C14:1)	1120:1143	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	8	3	located	present	1175:1181	arg1	contrast					1111:1118	contrast	1111:1118	contrast	1111:1118	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	8	3	located	present	1175:1181	arg2	C14:1					1138:1142	C14:1	1138:1142	C14:1	1138:1142	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	8	3	located	present	1175:1181	arg2	C18:0					1163:1167	C18:0	1163:1167	C18:0	1163:1167	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	6	4	theme	lauric	951:956	arg1	3-OH-C12:0					964:973	3-OH-C12:0	964:973	3-OH-C12:0	964:973	FAMES analysis showed the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0).
33529737	6	4	theme	lauric	951:956	arg1	acid					958:961	hydroxy lauric acid	943:961	hydroxy lauric acid (3-OH-C12:0)	943:974	FAMES analysis showed the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0).
33529737	3	5	theme	composition	313:323	arg1	analysis					325:332	the chemical composition analysis	300:332	the chemical composition analysis of leptospiral lipopolysaccharides (LPS) extracted from 5 pathogenic serovars like Autumnalis, Australis, Ballum, Grippotyphosa, Pomona, and the nonpathogenic serovar Andamana	300:508	Also, the chemical composition analysis of leptospiral lipopolysaccharides (LPS) extracted from 5 pathogenic serovars like Autumnalis, Australis, Ballum, Grippotyphosa, Pomona, and the nonpathogenic serovar Andamana was performed.
33529737	10	6	theme	Australis	1429:1437	arg1	Autumnalis					1417:1426	Autumnalis	1417:1426	Autumnalis	1417:1426	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	6	theme	Australis	1429:1437	arg1	sugars					1389:1394	6 deoxy sugars	1381:1394	6 deoxy sugars	1381:1394	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	6	theme	Australis	1429:1437	arg1	groups					1407:1412	methyl groups	1400:1412	methyl groups of Autumnalis, Australis, and Ballum	1400:1449	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	6	theme	Australis	1429:1437	arg1	Australis					1429:1437	Australis	1429:1437	Australis	1429:1437	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	6	theme	Australis	1429:1437	arg1	Ballum					1444:1449	Ballum	1444:1449	Ballum	1444:1449	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	6	7	theme	hydroxy	943:949	arg1	3-OH-C12:0					964:973	3-OH-C12:0	964:973	3-OH-C12:0	964:973	FAMES analysis showed the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0).
33529737	6	7	theme	hydroxy	943:949	arg1	acid					958:961	hydroxy lauric acid	943:961	hydroxy lauric acid (3-OH-C12:0)	943:974	FAMES analysis showed the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0).
33529737	7	8	dep	acid	1013:1016	arg1	C16					1019:1021	C16	1019:1021	C16: 1	1019:1024	Palmitoleic acid (C16: 1), and 3- hydroxy palmitate (3-OH-C16:0) was detected only in pathogenic serovars.
33529737	8	9	from	Andamana	1186:1193	arg1	present					1175:1181	present	1175:1181	present	1175:1181	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	11	10	theme	3-hydroxy	1498:1506	arg1	palmitate					1508:1516	3-hydroxy palmitate	1498:1516	3-hydroxy palmitate	1498:1516	Further, the presence of palmitoleic acid and 3-hydroxy palmitate may be the significant pathogen-associated predisposing factor.
33529737	4	11	theme	infrared	645:652	arg1	spectroscopy					654:665	infrared spectroscopy	645:665	infrared spectroscopy	645:665	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	7	12	theme	pathogenic	1087:1096	arg1	serovars					1098:1105	pathogenic serovars	1087:1105	pathogenic serovars	1087:1105	Palmitoleic acid (C16: 1), and 3- hydroxy palmitate (3-OH-C16:0) was detected only in pathogenic serovars.
33529737	8	13	from	contrast	1111:1118	arg1	present					1175:1181	present	1175:1181	present	1175:1181	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	9	14	theme	FTIR	1196:1199	arg1	analysis					1201:1208	FTIR analysis	1196:1208	FTIR analysis	1196:1208	FTIR analysis revealed C-O-C stretch of esters, 3°ROH functional groups and carbohydrate vibration range were similar among pathogenic serovars.
33529737	12	15	theme	leptospiral	1655:1665	arg1	pathogenesis					1680:1691	leptospiral LPS mediated pathogenesis	1655:1691	leptospiral LPS mediated pathogenesis	1655:1691	This mediates high osmolarity glycerol (HOG) mediated stress response in leptospiral LPS mediated pathogenesis.
33529737	2	16	theme	bioinformatics	272:285	arg1	tools					287:291	bioinformatics tools	272:291	bioinformatics tools	272:291	In this study, the genes involved in the LPS biosynthesis were analyzed and compared by bioinformatics tools.
33529737	3	17	theme	leptospiral	337:347	arg1	lipopolysaccharides					349:367	leptospiral lipopolysaccharides	337:367	leptospiral lipopolysaccharides (LPS) extracted from 5 pathogenic serovars like Autumnalis, Australis, Ballum, Grippotyphosa, Pomona, and the nonpathogenic serovar Andamana	337:508	Also, the chemical composition analysis of leptospiral lipopolysaccharides (LPS) extracted from 5 pathogenic serovars like Autumnalis, Australis, Ballum, Grippotyphosa, Pomona, and the nonpathogenic serovar Andamana was performed.
33529737	3	17	theme	leptospiral	337:347	arg1	LPS					370:372	LPS	370:372	LPS	370:372	Also, the chemical composition analysis of leptospiral lipopolysaccharides (LPS) extracted from 5 pathogenic serovars like Autumnalis, Australis, Ballum, Grippotyphosa, Pomona, and the nonpathogenic serovar Andamana was performed.
33529737	11	18	theme	pathogen-associated	1541:1559	arg1	factor					1574:1579	the significant pathogen-associated predisposing factor	1525:1579	the significant pathogen-associated predisposing factor	1525:1579	Further, the presence of palmitoleic acid and 3-hydroxy palmitate may be the significant pathogen-associated predisposing factor.
33529737	11	18	theme	pathogen-associated	1541:1559	arg1	presence					1465:1472	the presence	1461:1472	the presence of palmitoleic acid and 3-hydroxy palmitate	1461:1516	Further, the presence of palmitoleic acid and 3-hydroxy palmitate may be the significant pathogen-associated predisposing factor.
33529737	11	19	theme	significant	1529:1539	arg1	factor					1574:1579	the significant pathogen-associated predisposing factor	1525:1579	the significant pathogen-associated predisposing factor	1525:1579	Further, the presence of palmitoleic acid and 3-hydroxy palmitate may be the significant pathogen-associated predisposing factor.
33529737	11	19	theme	significant	1529:1539	arg1	presence					1465:1472	the presence	1461:1472	the presence of palmitoleic acid and 3-hydroxy palmitate	1461:1516	Further, the presence of palmitoleic acid and 3-hydroxy palmitate may be the significant pathogen-associated predisposing factor.
33529737	1	20	theme	Leptospira	172:181	arg1	Lipopolysaccharide					115:132	Lipopolysaccharide	115:132	Lipopolysaccharide (LPS)	115:138	Lipopolysaccharide (LPS) is the major surface antigen of Leptospira.
33529737	1	20	theme	Leptospira	172:181	arg1	antigen					161:167	the major surface antigen	143:167	the major surface antigen of Leptospira	143:181	Lipopolysaccharide (LPS) is the major surface antigen of Leptospira.
33529737	3	21	theme	lipopolysaccharides	349:367	arg1	analysis					325:332	the chemical composition analysis	300:332	the chemical composition analysis of leptospiral lipopolysaccharides (LPS) extracted from 5 pathogenic serovars like Autumnalis, Australis, Ballum, Grippotyphosa, Pomona, and the nonpathogenic serovar Andamana	300:508	Also, the chemical composition analysis of leptospiral lipopolysaccharides (LPS) extracted from 5 pathogenic serovars like Autumnalis, Australis, Ballum, Grippotyphosa, Pomona, and the nonpathogenic serovar Andamana was performed.
33529737	12	22	dep	mediated	1627:1634	arg1	glycerol					1612:1619	high osmolarity glycerol	1596:1619	high osmolarity glycerol	1596:1619	This mediates high osmolarity glycerol (HOG) mediated stress response in leptospiral LPS mediated pathogenesis.
33529737	9	23	theme	carbohydrate	1272:1283	arg1	range					1295:1299	carbohydrate vibration range	1272:1299	carbohydrate vibration range	1272:1299	FTIR analysis revealed C-O-C stretch of esters, 3°ROH functional groups and carbohydrate vibration range were similar among pathogenic serovars.
33529737	9	24	theme	functional	1250:1259	arg1	groups					1261:1266	3°ROH functional groups	1244:1266	3°ROH functional groups	1244:1266	FTIR analysis revealed C-O-C stretch of esters, 3°ROH functional groups and carbohydrate vibration range were similar among pathogenic serovars.
33529737	8	25	theme	myristoleic	1120:1130	arg1	C14:1					1138:1142	C14:1	1138:1142	C14:1	1138:1142	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	8	25	theme	myristoleic	1120:1130	arg1	acid					1132:1135	myristoleic acid	1120:1135	myristoleic acid (C14:1)	1120:1143	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	5	26	theme	endotoxicity	776:787	arg1	level					767:771	a significantly higher level	744:771	a significantly higher level of endotoxicity among pathogenic serovars (~0.490 EU/mL)	744:828	LAL assay showed a significantly higher level of endotoxicity among pathogenic serovars (~0.490 EU/mL) than that of nonpathogenic Andamana (~0.102 EU/mL).
33529737	6	27	theme	palmitic	920:927	arg1	acid					929:932	palmitic acid	920:932	palmitic acid (C16:0)	920:940	FAMES analysis showed the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0).
33529737	6	27	theme	palmitic	920:927	arg1	C16:0					935:939	C16:0	935:939	C16:0	935:939	FAMES analysis showed the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0).
33529737	7	28	theme	Palmitoleic	1001:1011	arg1	acid					1013:1016	Palmitoleic acid	1001:1016	Palmitoleic acid (C16: 1)	1001:1025	Palmitoleic acid (C16: 1), and 3- hydroxy palmitate (3-OH-C16:0) was detected only in pathogenic serovars.
33529737	5	29	theme	LAL	727:729	arg1	assay					731:735	LAL assay	727:735	LAL assay	727:735	LAL assay showed a significantly higher level of endotoxicity among pathogenic serovars (~0.490 EU/mL) than that of nonpathogenic Andamana (~0.102 EU/mL).
33529737	9	30	theme	pathogenic	1320:1329	arg1	serovars					1331:1338	pathogenic serovars	1320:1338	pathogenic serovars	1320:1338	FTIR analysis revealed C-O-C stretch of esters, 3°ROH functional groups and carbohydrate vibration range were similar among pathogenic serovars.
33529737	0	31	theme	Biochemical	0:10	arg1	analysis					12:19	Biochemical analysis	0:19	Biochemical analysis of leptospiral LPS	0:38	Biochemical analysis of leptospiral LPS explained the difference between pathogenic and non-pathogenic serogroups.
33529737	4	32	theme	amebocyte	551:559	arg1	LAL					575:577	LAL	575:577	LAL	575:577	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	4	32	theme	amebocyte	551:559	arg1	assay					568:572	Limulus amebocyte lysate assay	543:572	Limulus amebocyte lysate assay (LAL)	543:578	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	12	33	theme	mediated	1627:1634	arg1	response					1643:1650	high osmolarity glycerol (HOG) mediated stress response	1596:1650	high osmolarity glycerol (HOG) mediated stress response	1596:1650	This mediates high osmolarity glycerol (HOG) mediated stress response in leptospiral LPS mediated pathogenesis.
33529737	5	34	theme	nonpathogenic	843:855	arg1	Andamana					857:864	nonpathogenic Andamana	843:864	nonpathogenic Andamana (~0.102 EU/mL)	843:879	LAL assay showed a significantly higher level of endotoxicity among pathogenic serovars (~0.490 EU/mL) than that of nonpathogenic Andamana (~0.102 EU/mL).
33529737	5	34	theme	nonpathogenic	843:855	arg1	EU/mL					874:878	~0.102 EU/mL	867:878	~0.102 EU/mL	867:878	LAL assay showed a significantly higher level of endotoxicity among pathogenic serovars (~0.490 EU/mL) than that of nonpathogenic Andamana (~0.102 EU/mL).
33529737	0	35	theme	leptospiral	24:34	arg1	LPS					36:38	leptospiral LPS	24:38	leptospiral LPS	24:38	Biochemical analysis of leptospiral LPS explained the difference between pathogenic and non-pathogenic serogroups.
33529737	4	36	theme	Limulus	543:549	arg1	LAL					575:577	LAL	575:577	LAL	575:577	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	4	36	theme	Limulus	543:549	arg1	assay					568:572	Limulus amebocyte lysate assay	543:572	Limulus amebocyte lysate assay (LAL)	543:578	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	8	37	from	present	1175:1181	arg1	Andamana					1186:1193	Andamana	1186:1193	Andamana	1186:1193	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	8	37	from	present	1175:1181	arg1	contrast					1111:1118	contrast	1111:1118	contrast	1111:1118	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	4	38	dep	fourier	627:633	arg1	transform					635:643	transform	635:643	transform infrared spectroscopy	635:665	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	6	39	theme	acid	987:990	arg1	presence					908:915	the presence	904:915	the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0)	904:998	FAMES analysis showed the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0).
33529737	12	40	theme	LPS	1667:1669	arg1	pathogenesis					1680:1691	leptospiral LPS mediated pathogenesis	1655:1691	leptospiral LPS mediated pathogenesis	1655:1691	This mediates high osmolarity glycerol (HOG) mediated stress response in leptospiral LPS mediated pathogenesis.
33529737	6	41	theme	acid	929:932	arg1	presence					908:915	the presence	904:915	the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0)	904:998	FAMES analysis showed the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0).
33529737	7	42	dep	C16	1019:1021	arg1	1					1024:1024	1	1024:1024	1	1024:1024	Palmitoleic acid (C16: 1), and 3- hydroxy palmitate (3-OH-C16:0) was detected only in pathogenic serovars.
33529737	6	43	theme	FAMES	882:886	arg1	analysis					888:895	FAMES analysis	882:895	FAMES analysis	882:895	FAMES analysis showed the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0).
33529737	6	44	theme	oleic	981:985	arg1	C18:0					993:997	C18:0	993:997	C18:0	993:997	FAMES analysis showed the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0).
33529737	6	44	theme	oleic	981:985	arg1	acid					987:990	oleic acid	981:990	oleic acid (C18:0)	981:998	FAMES analysis showed the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0).
33529737	7	45	theme	hydroxy	1035:1041	arg1	3-OH-C16:0					1054:1063	3-OH-C16:0	1054:1063	3-OH-C16:0	1054:1063	Palmitoleic acid (C16: 1), and 3- hydroxy palmitate (3-OH-C16:0) was detected only in pathogenic serovars.
33529737	7	45	theme	hydroxy	1035:1041	arg1	palmitate					1043:1051	3- hydroxy palmitate	1032:1051	3- hydroxy palmitate (3-OH-C16:0)	1032:1064	Palmitoleic acid (C16: 1), and 3- hydroxy palmitate (3-OH-C16:0) was detected only in pathogenic serovars.
33529737	4	46	theme	lysate	561:566	arg1	LAL					575:577	LAL	575:577	LAL	575:577	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	4	46	theme	lysate	561:566	arg1	assay					568:572	Limulus amebocyte lysate assay	543:572	Limulus amebocyte lysate assay (LAL)	543:578	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	2	47	theme	LPS	225:227	arg1	biosynthesis					229:240	the LPS biosynthesis	221:240	the LPS biosynthesis	221:240	In this study, the genes involved in the LPS biosynthesis were analyzed and compared by bioinformatics tools.
33529737	0	48	theme	LPS	36:38	arg1	analysis					12:19	Biochemical analysis	0:19	Biochemical analysis of leptospiral LPS	0:38	Biochemical analysis of leptospiral LPS explained the difference between pathogenic and non-pathogenic serogroups.
33529737	5	49	theme	higher	760:765	arg1	level					767:771	a significantly higher level	744:771	a significantly higher level of endotoxicity among pathogenic serovars (~0.490 EU/mL)	744:828	LAL assay showed a significantly higher level of endotoxicity among pathogenic serovars (~0.490 EU/mL) than that of nonpathogenic Andamana (~0.102 EU/mL).
33529737	11	50	theme	predisposing	1561:1572	arg1	factor					1574:1579	the significant pathogen-associated predisposing factor	1525:1579	the significant pathogen-associated predisposing factor	1525:1579	Further, the presence of palmitoleic acid and 3-hydroxy palmitate may be the significant pathogen-associated predisposing factor.
33529737	11	50	theme	predisposing	1561:1572	arg1	presence					1465:1472	the presence	1461:1472	the presence of palmitoleic acid and 3-hydroxy palmitate	1461:1516	Further, the presence of palmitoleic acid and 3-hydroxy palmitate may be the significant pathogen-associated predisposing factor.
33529737	5	51	theme	pathogenic	795:804	arg1	EU/mL					823:827	~0.490 EU/mL	816:827	~0.490 EU/mL	816:827	LAL assay showed a significantly higher level of endotoxicity among pathogenic serovars (~0.490 EU/mL) than that of nonpathogenic Andamana (~0.102 EU/mL).
33529737	5	51	theme	pathogenic	795:804	arg1	serovars					806:813	pathogenic serovars	795:813	pathogenic serovars (~0.490 EU/mL)	795:828	LAL assay showed a significantly higher level of endotoxicity among pathogenic serovars (~0.490 EU/mL) than that of nonpathogenic Andamana (~0.102 EU/mL).
33529737	8	52	theme	stearic	1149:1155	arg1	C18:0					1163:1167	C18:0	1163:1167	C18:0	1163:1167	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	8	52	theme	stearic	1149:1155	arg1	acid					1157:1160	stearic acid	1149:1160	stearic acid (C18:0)	1149:1168	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	3	53	theme	pathogenic	392:401	arg1	serovars					403:410	5 pathogenic serovars	390:410	5 pathogenic serovars like Autumnalis, Australis, Ballum, Grippotyphosa, Pomona, and the nonpathogenic serovar Andamana	390:508	Also, the chemical composition analysis of leptospiral lipopolysaccharides (LPS) extracted from 5 pathogenic serovars like Autumnalis, Australis, Ballum, Grippotyphosa, Pomona, and the nonpathogenic serovar Andamana was performed.
33529737	10	54	theme	Ballum	1444:1449	arg1	Autumnalis					1417:1426	Autumnalis	1417:1426	Autumnalis	1417:1426	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	54	theme	Ballum	1444:1449	arg1	sugars					1389:1394	6 deoxy sugars	1381:1394	6 deoxy sugars	1381:1394	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	54	theme	Ballum	1444:1449	arg1	groups					1407:1412	methyl groups	1400:1412	methyl groups of Autumnalis, Australis, and Ballum	1400:1449	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	54	theme	Ballum	1444:1449	arg1	Australis					1429:1437	Australis	1429:1437	Australis	1429:1437	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	54	theme	Ballum	1444:1449	arg1	Ballum					1444:1449	Ballum	1444:1449	Ballum	1444:1449	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	8	55	attach	present	1175:1181	arg1	Andamana					1186:1193	Andamana	1186:1193	Andamana	1186:1193	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	8	55	attach	present	1175:1181	arg2	acid					1157:1160	stearic acid	1149:1160	stearic acid (C18:0)	1149:1168	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	8	55	attach	present	1175:1181	arg2	acid					1132:1135	myristoleic acid	1120:1135	myristoleic acid (C14:1)	1120:1143	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	8	55	attach	present	1175:1181	arg1	contrast					1111:1118	contrast	1111:1118	contrast	1111:1118	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	8	55	attach	present	1175:1181	arg2	C14:1					1138:1142	C14:1	1138:1142	C14:1	1138:1142	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	8	55	attach	present	1175:1181	arg2	C18:0					1163:1167	C18:0	1163:1167	C18:0	1163:1167	In contrast myristoleic acid (C14:1) and stearic acid (C18:0) were present in Andamana.
33529737	4	56	theme	magnetic	688:695	arg1	NMR					721:723	NMR	721:723	NMR	721:723	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	4	56	theme	magnetic	688:695	arg1	spectroscopy					707:718	nuclear magnetic resonance spectroscopy	680:718	nuclear magnetic resonance spectroscopy (NMR)	680:724	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	7	57	theme	3-	1032:1033	arg1	hydroxy					1035:1041	hydroxy	1035:1041	hydroxy	1035:1041	Palmitoleic acid (C16: 1), and 3- hydroxy palmitate (3-OH-C16:0) was detected only in pathogenic serovars.
33529737	9	58	theme	esters	1236:1241	arg1	stretch					1225:1231	C-O-C stretch	1219:1231	C-O-C stretch of esters	1219:1241	FTIR analysis revealed C-O-C stretch of esters, 3°ROH functional groups and carbohydrate vibration range were similar among pathogenic serovars.
33529737	10	59	theme	NMR	1345:1347	arg1	analysis					1349:1356	The NMR analysis	1341:1356	The NMR analysis	1341:1356	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	4	60	theme	nuclear	680:686	arg1	NMR					721:723	NMR	721:723	NMR	721:723	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	4	60	theme	nuclear	680:686	arg1	spectroscopy					707:718	nuclear magnetic resonance spectroscopy	680:718	nuclear magnetic resonance spectroscopy (NMR)	680:724	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	12	61	theme	high	1596:1599	arg1	glycerol					1612:1619	high osmolarity glycerol	1596:1619	high osmolarity glycerol	1596:1619	This mediates high osmolarity glycerol (HOG) mediated stress response in leptospiral LPS mediated pathogenesis.
33529737	9	62	theme	C-O-C	1219:1223	arg1	stretch					1225:1231	C-O-C stretch	1219:1231	C-O-C stretch of esters	1219:1241	FTIR analysis revealed C-O-C stretch of esters, 3°ROH functional groups and carbohydrate vibration range were similar among pathogenic serovars.
33529737	7	63	located	detected	1070:1077	arg2	3-OH-C16:0					1054:1063	3-OH-C16:0	1054:1063	3-OH-C16:0	1054:1063	Palmitoleic acid (C16: 1), and 3- hydroxy palmitate (3-OH-C16:0) was detected only in pathogenic serovars.
33529737	7	63	located	detected	1070:1077	arg2	palmitate					1043:1051	3- hydroxy palmitate	1032:1051	3- hydroxy palmitate (3-OH-C16:0)	1032:1064	Palmitoleic acid (C16: 1), and 3- hydroxy palmitate (3-OH-C16:0) was detected only in pathogenic serovars.
33529737	7	63	located	detected	1070:1077	arg2	acid					1013:1016	Palmitoleic acid	1001:1016	Palmitoleic acid (C16: 1)	1001:1025	Palmitoleic acid (C16: 1), and 3- hydroxy palmitate (3-OH-C16:0) was detected only in pathogenic serovars.
33529737	7	63	located	detected	1070:1077	arg1	serovars					1098:1105	pathogenic serovars	1087:1105	pathogenic serovars	1087:1105	Palmitoleic acid (C16: 1), and 3- hydroxy palmitate (3-OH-C16:0) was detected only in pathogenic serovars.
33529737	4	64	theme	chromatography-mass	585:603	arg1	GC-MS					619:623	GC-MS	619:623	GC-MS	619:623	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	4	64	theme	chromatography-mass	585:603	arg1	spectrometry					605:616	gas chromatography-mass spectrometry	581:616	gas chromatography-mass spectrometry (GC-MS)	581:624	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	10	65	theme	deoxy	1383:1387	arg1	sugars					1389:1394	6 deoxy sugars	1381:1394	6 deoxy sugars	1381:1394	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	9	66	theme	vibration	1285:1293	arg1	range					1295:1299	carbohydrate vibration range	1272:1299	carbohydrate vibration range	1272:1299	FTIR analysis revealed C-O-C stretch of esters, 3°ROH functional groups and carbohydrate vibration range were similar among pathogenic serovars.
33529737	11	67	theme	palmitoleic	1477:1487	arg1	acid					1489:1492	palmitoleic acid	1477:1492	palmitoleic acid	1477:1492	Further, the presence of palmitoleic acid and 3-hydroxy palmitate may be the significant pathogen-associated predisposing factor.
33529737	4	68	theme	resonance	697:705	arg1	NMR					721:723	NMR	721:723	NMR	721:723	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	4	68	theme	resonance	697:705	arg1	spectroscopy					707:718	nuclear magnetic resonance spectroscopy	680:718	nuclear magnetic resonance spectroscopy (NMR)	680:724	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	4	69	theme	gas	581:583	arg1	GC-MS					619:623	GC-MS	619:623	GC-MS	619:623	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	4	69	theme	gas	581:583	arg1	spectrometry					605:616	gas chromatography-mass spectrometry	581:616	gas chromatography-mass spectrometry (GC-MS)	581:624	Methods used were Limulus amebocyte lysate assay (LAL), gas chromatography-mass spectrometry (GC-MS), fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance spectroscopy (NMR).
33529737	0	70	theme	pathogenic	73:82	arg1	serogroups					103:112	pathogenic and non-pathogenic serogroups	73:112	pathogenic and non-pathogenic serogroups	73:112	Biochemical analysis of leptospiral LPS explained the difference between pathogenic and non-pathogenic serogroups.
33529737	12	71	theme	stress	1636:1641	arg1	response					1643:1650	high osmolarity glycerol (HOG) mediated stress response	1596:1650	high osmolarity glycerol (HOG) mediated stress response	1596:1650	This mediates high osmolarity glycerol (HOG) mediated stress response in leptospiral LPS mediated pathogenesis.
33529737	11	72	theme	acid	1489:1492	arg1	factor					1574:1579	the significant pathogen-associated predisposing factor	1525:1579	the significant pathogen-associated predisposing factor	1525:1579	Further, the presence of palmitoleic acid and 3-hydroxy palmitate may be the significant pathogen-associated predisposing factor.
33529737	11	72	theme	acid	1489:1492	arg1	presence					1465:1472	the presence	1461:1472	the presence of palmitoleic acid and 3-hydroxy palmitate	1461:1516	Further, the presence of palmitoleic acid and 3-hydroxy palmitate may be the significant pathogen-associated predisposing factor.
33529737	1	73	theme	major	147:151	arg1	Lipopolysaccharide					115:132	Lipopolysaccharide	115:132	Lipopolysaccharide (LPS)	115:138	Lipopolysaccharide (LPS) is the major surface antigen of Leptospira.
33529737	1	73	theme	major	147:151	arg1	antigen					161:167	the major surface antigen	143:167	the major surface antigen of Leptospira	143:181	Lipopolysaccharide (LPS) is the major surface antigen of Leptospira.
33529737	12	74	theme	osmolarity	1601:1610	arg1	glycerol					1612:1619	high osmolarity glycerol	1596:1619	high osmolarity glycerol	1596:1619	This mediates high osmolarity glycerol (HOG) mediated stress response in leptospiral LPS mediated pathogenesis.
33529737	12	75	theme	mediated	1671:1678	arg1	pathogenesis					1680:1691	leptospiral LPS mediated pathogenesis	1655:1691	leptospiral LPS mediated pathogenesis	1655:1691	This mediates high osmolarity glycerol (HOG) mediated stress response in leptospiral LPS mediated pathogenesis.
33529737	10	76	theme	Autumnalis	1417:1426	arg1	Autumnalis					1417:1426	Autumnalis	1417:1426	Autumnalis	1417:1426	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	76	theme	Autumnalis	1417:1426	arg1	sugars					1389:1394	6 deoxy sugars	1381:1394	6 deoxy sugars	1381:1394	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	76	theme	Autumnalis	1417:1426	arg1	groups					1407:1412	methyl groups	1400:1412	methyl groups of Autumnalis, Australis, and Ballum	1400:1449	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	76	theme	Autumnalis	1417:1426	arg1	Australis					1429:1437	Australis	1429:1437	Australis	1429:1437	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	10	76	theme	Autumnalis	1417:1426	arg1	Ballum					1444:1449	Ballum	1444:1449	Ballum	1444:1449	The NMR analysis reveals similarity for 6 deoxy sugars and methyl groups of Autumnalis, Australis, and Ballum.
33529737	11	77	theme	palmitate	1508:1516	arg1	factor					1574:1579	the significant pathogen-associated predisposing factor	1525:1579	the significant pathogen-associated predisposing factor	1525:1579	Further, the presence of palmitoleic acid and 3-hydroxy palmitate may be the significant pathogen-associated predisposing factor.
33529737	11	77	theme	palmitate	1508:1516	arg1	presence					1465:1472	the presence	1461:1472	the presence of palmitoleic acid and 3-hydroxy palmitate	1461:1516	Further, the presence of palmitoleic acid and 3-hydroxy palmitate may be the significant pathogen-associated predisposing factor.
33529737	1	78	theme	surface	153:159	arg1	Lipopolysaccharide					115:132	Lipopolysaccharide	115:132	Lipopolysaccharide (LPS)	115:138	Lipopolysaccharide (LPS) is the major surface antigen of Leptospira.
33529737	1	78	theme	surface	153:159	arg1	antigen					161:167	the major surface antigen	143:167	the major surface antigen of Leptospira	143:181	Lipopolysaccharide (LPS) is the major surface antigen of Leptospira.
33529737	6	79	theme	acid	958:961	arg1	presence					908:915	the presence	904:915	the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0)	904:998	FAMES analysis showed the presence of palmitic acid (C16:0), hydroxy lauric acid (3-OH-C12:0), and oleic acid (C18:0).
33962112	4	0	theme	slow	998:1001	arg1	rate					1003:1006	a slow rate	996:1006	a slow rate in low pH solutions	996:1026	The nanocomposites played as a pH-responsive drug delivery process to release ulvan at a fast rate in pH 7.4 buffer solution but at a slow rate in low pH solutions.
33962112	1	1	theme	hydroxypropyl	327:339	arg1	HPCCS					374:378	HPCCS	374:378	HPCCS	374:378	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	1	1	theme	hydroxypropyl	327:339	arg1	chitosan					364:371	hydroxypropyl cellulose cross-linked chitosan	327:371	hydroxypropyl cellulose cross-linked chitosan (HPCCS)	327:379	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	2	2	with	dots	458:461	arg1	distribution					473:484	size distribution	468:484	size distribution of 3-5 nm	468:494	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm were completely encapsulated in the HPCCS/UN NPs to obtain composites, which indicated unique characteristics with respect to antimicrobial, pH-responsive and optical properties.
33962112	0	3	theme	drug	108:111	arg1	delivery					113:120	drug delivery	108:120	drug delivery	108:120	Preparation of carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan nanocomposites for drug delivery, sunlight catalytic and antimicrobial application.
33962112	1	4	theme	cellulose	341:349	arg1	HPCCS					374:378	HPCCS	374:378	HPCCS	374:378	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	1	4	theme	cellulose	341:349	arg1	chitosan					364:371	hydroxypropyl cellulose cross-linked chitosan	327:371	hydroxypropyl cellulose cross-linked chitosan (HPCCS)	327:379	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	1	5	theme	chemical	413:420	arg1	method					422:427	chemical method	413:427	chemical method	413:427	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	1	6	theme	CDs	267:269	arg1	dots					299:302	carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	254:302	carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	254:302	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	1	7	theme	cross-linked	351:362	arg1	HPCCS					374:378	HPCCS	374:378	HPCCS	374:378	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	1	7	theme	cross-linked	351:362	arg1	chitosan					364:371	hydroxypropyl cellulose cross-linked chitosan	327:371	hydroxypropyl cellulose cross-linked chitosan (HPCCS)	327:379	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	2	8	theme	unique	583:588	arg1	characteristics					590:604	unique characteristics	583:604	unique characteristics	583:604	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm were completely encapsulated in the HPCCS/UN NPs to obtain composites, which indicated unique characteristics with respect to antimicrobial, pH-responsive and optical properties.
33962112	2	9	theme	optical	655:661	arg1	properties					663:672	antimicrobial, pH-responsive and optical properties	622:672	antimicrobial, pH-responsive and optical properties	622:672	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm were completely encapsulated in the HPCCS/UN NPs to obtain composites, which indicated unique characteristics with respect to antimicrobial, pH-responsive and optical properties.
33962112	4	10	from	rate	958:961	arg1	solution					980:987	pH 7.4 buffer solution	966:987	pH 7.4 buffer solution	966:987	The nanocomposites played as a pH-responsive drug delivery process to release ulvan at a fast rate in pH 7.4 buffer solution but at a slow rate in low pH solutions.
33962112	4	11	theme	fast	953:956	arg1	rate					958:961	a fast rate	951:961	a fast rate in pH 7.4 buffer solution	951:987	The nanocomposites played as a pH-responsive drug delivery process to release ulvan at a fast rate in pH 7.4 buffer solution but at a slow rate in low pH solutions.
33962112	1	12	theme	chitosan	364:371	arg1	preparation					312:322	the preparation	308:322	the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN)	308:394	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	4	13	theme	pH	1015:1016	arg1	solutions					1018:1026	low pH solutions	1011:1026	low pH solutions	1011:1026	The nanocomposites played as a pH-responsive drug delivery process to release ulvan at a fast rate in pH 7.4 buffer solution but at a slow rate in low pH solutions.
33962112	1	14	theme	/Hematite	271:279	arg1	dots					299:302	carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	254:302	carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	254:302	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	3	15	theme	dual-emission	752:764	arg1	single-excitation					724:740	a single-excitation	722:740	a single-excitation (440 nm)	722:749	The CDs-HQDs/HPCCS/UN nanocomposites exhibited a single-excitation (440 nm), dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs).
33962112	3	15	theme	dual-emission	752:764	arg1	property					779:786	dual-emission fluorescence property	752:786	dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs)	752:861	The CDs-HQDs/HPCCS/UN nanocomposites exhibited a single-excitation (440 nm), dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs).
33962112	2	16	theme	pH-responsive	637:649	arg1	properties					663:672	antimicrobial, pH-responsive and optical properties	622:672	antimicrobial, pH-responsive and optical properties	622:672	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm were completely encapsulated in the HPCCS/UN NPs to obtain composites, which indicated unique characteristics with respect to antimicrobial, pH-responsive and optical properties.
33962112	0	17	theme	catalytic	132:140	arg1	sunlight					123:130	sunlight catalytic	123:140	sunlight catalytic	123:140	Preparation of carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan nanocomposites for drug delivery, sunlight catalytic and antimicrobial application.
33962112	5	18	dep	pollutant	1151:1159	arg1	%					1165:1165	>98%	1162:1165	>98%	1162:1165	The CDs-HQDs/HPCCS/UN nanocomposites gained the highest photocatalytic activity for degrading 4-chlorophenol (4-CPh) as a pollutant (>98% during 70 min under sunlight irradiation).
33962112	2	19	theme	antimicrobial	622:634	arg1	properties					663:672	antimicrobial, pH-responsive and optical properties	622:672	antimicrobial, pH-responsive and optical properties	622:672	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm were completely encapsulated in the HPCCS/UN NPs to obtain composites, which indicated unique characteristics with respect to antimicrobial, pH-responsive and optical properties.
33962112	4	20	theme	low	1011:1013	arg1	solutions					1018:1026	low pH solutions	1011:1026	low pH solutions	1011:1026	The nanocomposites played as a pH-responsive drug delivery process to release ulvan at a fast rate in pH 7.4 buffer solution but at a slow rate in low pH solutions.
33962112	2	21	theme	Carbon	430:435	arg1	dots					458:461	Carbon dots/α-Fe2O3 quantum dots	430:461	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm	430:494	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm were completely encapsulated in the HPCCS/UN NPs to obtain composites, which indicated unique characteristics with respect to antimicrobial, pH-responsive and optical properties.
33962112	2	22	theme	size	468:471	arg1	distribution					473:484	size distribution	468:484	size distribution of 3-5 nm	468:494	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm were completely encapsulated in the HPCCS/UN NPs to obtain composites, which indicated unique characteristics with respect to antimicrobial, pH-responsive and optical properties.
33962112	6	23	theme	inhibitory	1255:1264	arg1	influences					1266:1275	great inhibitory influences	1249:1275	great inhibitory influences	1249:1275	Moreover, the nanocomposites indicated great inhibitory influences towards bacterial and fungal.
33962112	1	24	theme	thermal	205:211	arg1	method					226:231	the thermal and chemical method	201:231	the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	201:302	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	3	25	from	HPCCS/UN	849:856	arg1	628 nm					800:805	628 nm	800:805	628 nm	800:805	The CDs-HQDs/HPCCS/UN nanocomposites exhibited a single-excitation (440 nm), dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs).
33962112	3	25	from	HPCCS/UN	849:856	arg1	505 nm					789:794	505 nm	789:794	505 nm	789:794	The CDs-HQDs/HPCCS/UN nanocomposites exhibited a single-excitation (440 nm), dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs).
33962112	6	26	theme	great	1249:1253	arg1	influences					1266:1275	great inhibitory influences	1249:1275	great inhibitory influences	1249:1275	Moreover, the nanocomposites indicated great inhibitory influences towards bacterial and fungal.
33962112	3	27	theme	CDs-HQDs/HPCCS/UN	679:695	arg1	nanocomposites					697:710	The CDs-HQDs/HPCCS/UN nanocomposites	675:710	The CDs-HQDs/HPCCS/UN nanocomposites	675:710	The CDs-HQDs/HPCCS/UN nanocomposites exhibited a single-excitation (440 nm), dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs).
33962112	5	28	theme	highest	1077:1083	arg1	activity					1100:1107	the highest photocatalytic activity	1073:1107	the highest photocatalytic activity for degrading 4-chlorophenol (4-CPh) as a pollutant (>98% during 70 min under sunlight irradiation)	1073:1207	The CDs-HQDs/HPCCS/UN nanocomposites gained the highest photocatalytic activity for degrading 4-chlorophenol (4-CPh) as a pollutant (>98% during 70 min under sunlight irradiation).
33962112	0	29	theme	dots-hematite	22:34	arg1	cellulose-chitosan					70:87	carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan	15:87	carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan	15:87	Preparation of carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan nanocomposites for drug delivery, sunlight catalytic and antimicrobial application.
33962112	1	30	theme	α-Fe2O3	282:288	arg1	dots					299:302	carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	254:302	carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	254:302	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	3	31	from	CDs-HQDs	836:843	arg1	628 nm					800:805	628 nm	800:805	628 nm	800:805	The CDs-HQDs/HPCCS/UN nanocomposites exhibited a single-excitation (440 nm), dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs).
33962112	3	31	from	CDs-HQDs	836:843	arg1	505 nm					789:794	505 nm	789:794	505 nm	789:794	The CDs-HQDs/HPCCS/UN nanocomposites exhibited a single-excitation (440 nm), dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs).
33962112	1	32	link	cross-linked	351:362	arg1	HPCCS					374:378	HPCCS	374:378	HPCCS	374:378	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	1	32	link	cross-linked	351:362	arg1	chitosan					364:371	hydroxypropyl cellulose cross-linked chitosan	327:371	hydroxypropyl cellulose cross-linked chitosan (HPCCS)	327:379	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	1	33	theme	chemical	217:224	arg1	method					226:231	the thermal and chemical method	201:231	the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	201:302	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	0	34	theme	carbon	15:20	arg1	cellulose-chitosan					70:87	carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan	15:87	carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan	15:87	Preparation of carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan nanocomposites for drug delivery, sunlight catalytic and antimicrobial application.
33962112	3	35	theme	fluorescence	766:777	arg1	single-excitation					724:740	a single-excitation	722:740	a single-excitation (440 nm)	722:749	The CDs-HQDs/HPCCS/UN nanocomposites exhibited a single-excitation (440 nm), dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs).
33962112	3	35	theme	fluorescence	766:777	arg1	property					779:786	dual-emission fluorescence property	752:786	dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs)	752:861	The CDs-HQDs/HPCCS/UN nanocomposites exhibited a single-excitation (440 nm), dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs).
33962112	0	36	theme	antimicrobial	146:158	arg1	application					160:170	antimicrobial application	146:170	antimicrobial application	146:170	Preparation of carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan nanocomposites for drug delivery, sunlight catalytic and antimicrobial application.
33962112	0	37	theme	dots-loaded	44:54	arg1	cellulose-chitosan					70:87	carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan	15:87	carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan	15:87	Preparation of carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan nanocomposites for drug delivery, sunlight catalytic and antimicrobial application.
33962112	1	38	theme	quantum	291:297	arg1	dots					299:302	carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	254:302	carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	254:302	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	2	39	theme	HPCCS/UN	532:539	arg1	NPs					541:543	the HPCCS/UN NPs	528:543	the HPCCS/UN NPs	528:543	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm were completely encapsulated in the HPCCS/UN NPs to obtain composites, which indicated unique characteristics with respect to antimicrobial, pH-responsive and optical properties.
33962112	1	40	theme	ulvan	385:389	arg1	preparation					312:322	the preparation	308:322	the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN)	308:394	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	0	41	theme	quantum	36:42	arg1	cellulose-chitosan					70:87	carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan	15:87	carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan	15:87	Preparation of carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan nanocomposites for drug delivery, sunlight catalytic and antimicrobial application.
33962112	1	42	theme	dots	299:302	arg1	synthesis					241:249	the synthesis	237:249	the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	237:302	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	5	43	theme	photocatalytic	1085:1098	arg1	activity					1100:1107	the highest photocatalytic activity	1073:1107	the highest photocatalytic activity for degrading 4-chlorophenol (4-CPh) as a pollutant (>98% during 70 min under sunlight irradiation)	1073:1207	The CDs-HQDs/HPCCS/UN nanocomposites gained the highest photocatalytic activity for degrading 4-chlorophenol (4-CPh) as a pollutant (>98% during 70 min under sunlight irradiation).
33962112	5	44	theme	sunlight	1187:1194	arg1	irradiation					1196:1206	sunlight irradiation	1187:1206	sunlight irradiation	1187:1206	The CDs-HQDs/HPCCS/UN nanocomposites gained the highest photocatalytic activity for degrading 4-chlorophenol (4-CPh) as a pollutant (>98% during 70 min under sunlight irradiation).
33962112	0	45	theme	cellulose-chitosan	70:87	arg1	Preparation					0:10	Preparation	0:10	Preparation of carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan	0:87	Preparation of carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan nanocomposites for drug delivery, sunlight catalytic and antimicrobial application.
33962112	4	46	from	rate	1003:1006	arg1	solutions					1018:1026	low pH solutions	1011:1026	low pH solutions	1011:1026	The nanocomposites played as a pH-responsive drug delivery process to release ulvan at a fast rate in pH 7.4 buffer solution but at a slow rate in low pH solutions.
33962112	4	47	theme	delivery	914:921	arg1	process					923:929	a pH-responsive drug delivery process	893:929	a pH-responsive drug delivery process	893:929	The nanocomposites played as a pH-responsive drug delivery process to release ulvan at a fast rate in pH 7.4 buffer solution but at a slow rate in low pH solutions.
33962112	4	48	theme	buffer	973:978	arg1	solution					980:987	pH 7.4 buffer solution	966:987	pH 7.4 buffer solution	966:987	The nanocomposites played as a pH-responsive drug delivery process to release ulvan at a fast rate in pH 7.4 buffer solution but at a slow rate in low pH solutions.
33962112	0	49	theme	hydroxypropyl	56:68	arg1	cellulose-chitosan					70:87	carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan	15:87	carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan	15:87	Preparation of carbon dots-hematite quantum dots-loaded hydroxypropyl cellulose-chitosan nanocomposites for drug delivery, sunlight catalytic and antimicrobial application.
33962112	3	50	dep	CDs-HQDs	836:843	arg1	NPs					858:860	NPs	858:860	NPs	858:860	The CDs-HQDs/HPCCS/UN nanocomposites exhibited a single-excitation (440 nm), dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs).
33962112	4	51	theme	drug	909:912	arg1	process					923:929	a pH-responsive drug delivery process	893:929	a pH-responsive drug delivery process	893:929	The nanocomposites played as a pH-responsive drug delivery process to release ulvan at a fast rate in pH 7.4 buffer solution but at a slow rate in low pH solutions.
33962112	2	52	theme	dots/α-Fe2O3	437:448	arg1	dots					458:461	Carbon dots/α-Fe2O3 quantum dots	430:461	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm	430:494	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm were completely encapsulated in the HPCCS/UN NPs to obtain composites, which indicated unique characteristics with respect to antimicrobial, pH-responsive and optical properties.
33962112	3	53	dep	property	779:786	arg1	628 nm					800:805	628 nm	800:805	628 nm	800:805	The CDs-HQDs/HPCCS/UN nanocomposites exhibited a single-excitation (440 nm), dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs).
33962112	3	53	dep	property	779:786	arg1	505 nm					789:794	505 nm	789:794	505 nm	789:794	The CDs-HQDs/HPCCS/UN nanocomposites exhibited a single-excitation (440 nm), dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs).
33962112	4	54	theme	pH-responsive	895:907	arg1	process					923:929	a pH-responsive drug delivery process	893:929	a pH-responsive drug delivery process	893:929	The nanocomposites played as a pH-responsive drug delivery process to release ulvan at a fast rate in pH 7.4 buffer solution but at a slow rate in low pH solutions.
33962112	5	55	theme	CDs-HQDs/HPCCS/UN	1033:1049	arg1	nanocomposites					1051:1064	The CDs-HQDs/HPCCS/UN nanocomposites	1029:1064	The CDs-HQDs/HPCCS/UN nanocomposites	1029:1064	The CDs-HQDs/HPCCS/UN nanocomposites gained the highest photocatalytic activity for degrading 4-chlorophenol (4-CPh) as a pollutant (>98% during 70 min under sunlight irradiation).
33962112	2	56	theme	3-5 nm	489:494	arg1	distribution					473:484	size distribution	468:484	size distribution of 3-5 nm	468:494	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm were completely encapsulated in the HPCCS/UN NPs to obtain composites, which indicated unique characteristics with respect to antimicrobial, pH-responsive and optical properties.
33962112	1	57	theme	carbon	254:259	arg1	dots					299:302	carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	254:302	carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	254:302	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
33962112	2	58	theme	quantum	450:456	arg1	dots					458:461	Carbon dots/α-Fe2O3 quantum dots	430:461	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm	430:494	Carbon dots/α-Fe2O3 quantum dots with size distribution of 3-5 nm were completely encapsulated in the HPCCS/UN NPs to obtain composites, which indicated unique characteristics with respect to antimicrobial, pH-responsive and optical properties.
33962112	3	59	dep	green	811:815	arg1	light					825:829	light	825:829	light	825:829	The CDs-HQDs/HPCCS/UN nanocomposites exhibited a single-excitation (440 nm), dual-emission fluorescence property (505 nm and 628 nm for green and red light from CDs-HQDs and HPCCS/UN NPs).
33962112	1	60	theme	dots	261:264	arg1	dots					299:302	carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	254:302	carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots	254:302	In this project, we studied the thermal and chemical method for the synthesis of carbon dots (CDs)/Hematite (α-Fe2O3) quantum dots and the preparation of hydroxypropyl cellulose cross-linked chitosan (HPCCS) and ulvan (UN) was performed by chemical method.
34450150	4	0	theme	Co	806:807	arg1	solution					813:820	Co(II) solution	806:820	Co(II) solution	806:820	The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.
34450150	2	1	theme	initial	510:516	arg1	II					521:522	II	521:522	II	521:522	The method of using MCC-MH to adsorb and remove Co(II) was studied under different pH values, adsorbent dosages, contact times, initial Co(II) ion concentrations, and temperatures.
34450150	2	1	theme	initial	510:516	arg1	Co					518:519	initial Co	510:519	initial Co(II) ion concentrations	510:542	The method of using MCC-MH to adsorb and remove Co(II) was studied under different pH values, adsorbent dosages, contact times, initial Co(II) ion concentrations, and temperatures.
34450150	3	2	theme	solution	689:696	arg1	pH					698:699	solution pH	689:699	a Co(II) solution pH of 6.0-8.0	680:710	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	2	3	theme	pH	465:466	arg1	values					468:473	different pH values	455:473	different pH values	455:473	The method of using MCC-MH to adsorb and remove Co(II) was studied under different pH values, adsorbent dosages, contact times, initial Co(II) ion concentrations, and temperatures.
34450150	1	4	theme	adsorbent	322:330	arg1	hydroxide					297:305	a MCC-magnesium hydroxide	281:305	a MCC-magnesium hydroxide (MH)	281:310	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	1	4	theme	adsorbent	322:330	arg1	MH					308:309	MH	308:309	MH	308:309	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	5	5	theme	spontaneous	1144:1154	arg1	adsorption					1107:1116	the adsorption	1103:1116	the adsorption of Co(II) by MCC-MH	1103:1136	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	5	5	theme	spontaneous	1144:1154	arg1	reaction					1168:1175	a spontaneous endothermic reaction	1142:1175	a spontaneous endothermic reaction	1142:1175	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	3	6	theme	initial	716:722	arg1	concentration					731:743	an initial Co(II) concentration	713:743	an initial Co(II) concentration of 300 mg/L	713:755	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	6	7	theme	intraparticle	1344:1356	arg1	diffusion					1358:1366	intraparticle diffusion	1344:1366	intraparticle diffusion	1344:1366	Analytical studies showed that Co(II) adsorption on MCC-MH composites is affected by chemical adsorption and involves the influence of intraparticle diffusion to a certain extent.
34450150	5	8	theme	endothermic	1156:1166	arg1	adsorption					1107:1116	the adsorption	1103:1116	the adsorption of Co(II) by MCC-MH	1103:1136	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	5	8	theme	endothermic	1156:1166	arg1	reaction					1168:1175	a spontaneous endothermic reaction	1142:1175	a spontaneous endothermic reaction	1142:1175	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	3	9	theme	Co	724:725	arg1	concentration					731:743	an initial Co(II) concentration	713:743	an initial Co(II) concentration of 300 mg/L	713:755	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	0	10	theme	adsorption	59:68	arg1	method					70:75	adsorption method	59:75	adsorption method using microcrystalline cellulose-magnesium hydroxide	59:128	Removal of heavy metal ion cobalt (II) from wastewater via adsorption method using microcrystalline cellulose-magnesium hydroxide.
34450150	2	11	theme	contact	495:501	arg1	times					503:507	contact times	495:507	contact times	495:507	The method of using MCC-MH to adsorb and remove Co(II) was studied under different pH values, adsorbent dosages, contact times, initial Co(II) ion concentrations, and temperatures.
34450150	6	12	from	adsorption	1247:1256	arg1	composites					1268:1277	MCC-MH composites	1261:1277	MCC-MH composites	1261:1277	Analytical studies showed that Co(II) adsorption on MCC-MH composites is affected by chemical adsorption and involves the influence of intraparticle diffusion to a certain extent.
34450150	5	13	theme	pseudo-second-order	1064:1082	arg1	model					1092:1096	the pseudo-second-order kinetic model	1060:1096	the pseudo-second-order kinetic model	1060:1096	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	1	14	theme	aqueous	253:259	arg1	solution					261:268	an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion	250:379	an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion	250:379	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	0	15	theme	microcrystalline	83:98	arg1	hydroxide					120:128	microcrystalline cellulose-magnesium hydroxide	83:128	microcrystalline cellulose-magnesium hydroxide	83:128	Removal of heavy metal ion cobalt (II) from wastewater via adsorption method using microcrystalline cellulose-magnesium hydroxide.
34450150	3	16	theme	2.5 mg/mL	622:630	arg1	Co					682:683	a Co(II) solution pH of 6.0-8.0	680:710	a Co(II) solution pH of 6.0-8.0	680:710	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	16	theme	2.5 mg/mL	622:630	arg1	dosage					612:617	an MCC-MH dosage	602:617	an MCC-MH dosage of 2.5 mg/mL	602:630	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	16	theme	2.5 mg/mL	622:630	arg1	concentration					731:743	an initial Co(II) concentration	713:743	an initial Co(II) concentration of 300 mg/L	713:755	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	16	theme	2.5 mg/mL	622:630	arg1	time					664:667	a contact reaction equilibrium time	633:667	a contact reaction equilibrium time of 50 min	633:677	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	16	theme	2.5 mg/mL	622:630	arg1	temperature					764:774	a temperature	762:774	a temperature of 303 K	762:783	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	2	17	theme	ion	525:527	arg1	concentrations					529:542	initial Co(II) ion concentrations	510:542	initial Co(II) ion concentrations	510:542	The method of using MCC-MH to adsorb and remove Co(II) was studied under different pH values, adsorbent dosages, contact times, initial Co(II) ion concentrations, and temperatures.
34450150	6	18	theme	certain	1373:1379	arg1	extent					1381:1386	a certain extent	1371:1386	a certain extent	1371:1386	Analytical studies showed that Co(II) adsorption on MCC-MH composites is affected by chemical adsorption and involves the influence of intraparticle diffusion to a certain extent.
34450150	3	19	theme	300 mg/L	748:755	arg1	Co					682:683	a Co(II) solution pH of 6.0-8.0	680:710	a Co(II) solution pH of 6.0-8.0	680:710	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	19	theme	300 mg/L	748:755	arg1	dosage					612:617	an MCC-MH dosage	602:617	an MCC-MH dosage of 2.5 mg/mL	602:630	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	19	theme	300 mg/L	748:755	arg1	concentration					731:743	an initial Co(II) concentration	713:743	an initial Co(II) concentration of 300 mg/L	713:755	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	19	theme	300 mg/L	748:755	arg1	time					664:667	a contact reaction equilibrium time	633:667	a contact reaction equilibrium time of 50 min	633:677	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	19	theme	300 mg/L	748:755	arg1	temperature					764:774	a temperature	762:774	a temperature of 303 K	762:783	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	20	theme	MCC-MH	605:610	arg1	dosage					612:617	an MCC-MH dosage	602:617	an MCC-MH dosage of 2.5 mg/mL	602:630	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	5	21	theme	optimized	1187:1195	arg1	conditions					1197:1206	the optimized conditions	1183:1206	the optimized conditions	1183:1206	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	6	22	theme	diffusion	1358:1366	arg1	influence					1331:1339	the influence	1327:1339	the influence of intraparticle diffusion to a certain extent	1327:1386	Analytical studies showed that Co(II) adsorption on MCC-MH composites is affected by chemical adsorption and involves the influence of intraparticle diffusion to a certain extent.
34450150	1	23	theme	magnesium	165:173	arg1	sulfate					175:181	magnesium sulfate	165:181	magnesium sulfate hexahydrate	165:193	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	5	24	theme	kinetic	1024:1030	arg1	data					1032:1035	the kinetic data	1020:1035	the kinetic data of Co(II)	1020:1045	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	5	25	theme	adsorption	957:966	arg1	isotherm					968:975	The adsorption isotherm	953:975	The adsorption isotherm of Co(II)	953:985	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	1	26	theme	sulfate	175:181	arg1	hexahydrate					183:193	magnesium sulfate hexahydrate	165:193	magnesium sulfate hexahydrate	165:193	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	3	27	theme	process	575:581	arg1	parameters					583:592	The optimal process parameters	563:592	The optimal process parameters	563:592	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	28	theme	contact	635:641	arg1	time					664:667	a contact reaction equilibrium time	633:667	a contact reaction equilibrium time of 50 min	633:677	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	2	29	theme	Co	518:519	arg1	concentrations					529:542	initial Co(II) ion concentrations	510:542	initial Co(II) ion concentrations	510:542	The method of using MCC-MH to adsorb and remove Co(II) was studied under different pH values, adsorbent dosages, contact times, initial Co(II) ion concentrations, and temperatures.
34450150	1	30	theme	heavy	358:362	arg1	ion					377:379	heavy metal Co(II) ion	358:379	heavy metal Co(II) ion	358:379	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	0	31	theme	metal	17:21	arg1	cobalt					27:32	heavy metal ion cobalt	11:32	heavy metal ion cobalt (II)	11:37	Removal of heavy metal ion cobalt (II) from wastewater via adsorption method using microcrystalline cellulose-magnesium hydroxide.
34450150	0	31	theme	metal	17:21	arg1	II					35:36	II	35:36	II	35:36	Removal of heavy metal ion cobalt (II) from wastewater via adsorption method using microcrystalline cellulose-magnesium hydroxide.
34450150	1	32	used	used	343:346	arg2	MH					308:309	MH	308:309	MH	308:309	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	1	32	used	used	343:346	arg2	hydroxide					297:305	a MCC-magnesium hydroxide	281:305	a MCC-magnesium hydroxide (MH)	281:310	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	4	33	theme	adsorption	871:880	arg1	capacity					882:889	the maximum adsorption capacity	859:889	the maximum adsorption capacity of MCC-MH	859:899	The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.
34450150	0	34	theme	heavy	11:15	arg1	cobalt					27:32	heavy metal ion cobalt	11:32	heavy metal ion cobalt (II)	11:37	Removal of heavy metal ion cobalt (II) from wastewater via adsorption method using microcrystalline cellulose-magnesium hydroxide.
34450150	0	34	theme	heavy	11:15	arg1	II					35:36	II	35:36	II	35:36	Removal of heavy metal ion cobalt (II) from wastewater via adsorption method using microcrystalline cellulose-magnesium hydroxide.
34450150	0	35	theme	cellulose-magnesium	100:118	arg1	hydroxide					120:128	microcrystalline cellulose-magnesium hydroxide	83:128	microcrystalline cellulose-magnesium hydroxide	83:128	Removal of heavy metal ion cobalt (II) from wastewater via adsorption method using microcrystalline cellulose-magnesium hydroxide.
34450150	4	36	theme	MCC-MH	894:899	arg1	capacity					882:889	the maximum adsorption capacity	859:889	the maximum adsorption capacity of MCC-MH	859:899	The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.
34450150	0	37	theme	cobalt	27:32	arg1	Removal					0:6	Removal	0:6	Removal of heavy metal ion cobalt (II) from wastewater via adsorption method using microcrystalline cellulose-magnesium hydroxide.	0:129	Removal of heavy metal ion cobalt (II) from wastewater via adsorption method using microcrystalline cellulose-magnesium hydroxide.
34450150	5	38	theme	Co	980:981	arg1	isotherm					968:975	The adsorption isotherm	953:975	The adsorption isotherm of Co(II)	953:985	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	2	39	theme	different	455:463	arg1	values					468:473	different pH values	455:473	different pH values	455:473	The method of using MCC-MH to adsorb and remove Co(II) was studied under different pH values, adsorbent dosages, contact times, initial Co(II) ion concentrations, and temperatures.
34450150	0	40	from	wastewater	44:53	arg1	Removal					0:6	Removal	0:6	Removal of heavy metal ion cobalt (II) from wastewater via adsorption method using microcrystalline cellulose-magnesium hydroxide.	0:129	Removal of heavy metal ion cobalt (II) from wastewater via adsorption method using microcrystalline cellulose-magnesium hydroxide.
34450150	6	41	theme	Co	1240:1241	arg1	adsorption					1247:1256	Co(II) adsorption	1240:1256	Co(II) adsorption on MCC-MH composites	1240:1277	Analytical studies showed that Co(II) adsorption on MCC-MH composites is affected by chemical adsorption and involves the influence of intraparticle diffusion to a certain extent.
34450150	1	42	theme	trisodium	200:208	arg1	citrate					210:216	trisodium citrate	200:216	trisodium citrate	200:216	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	0	43	theme	ion	23:25	arg1	cobalt					27:32	heavy metal ion cobalt	11:32	heavy metal ion cobalt (II)	11:37	Removal of heavy metal ion cobalt (II) from wastewater via adsorption method using microcrystalline cellulose-magnesium hydroxide.
34450150	0	43	theme	ion	23:25	arg1	II					35:36	II	35:36	II	35:36	Removal of heavy metal ion cobalt (II) from wastewater via adsorption method using microcrystalline cellulose-magnesium hydroxide.
34450150	1	44	theme	MCC-magnesium	283:295	arg1	hydroxide					297:305	a MCC-magnesium hydroxide	281:305	a MCC-magnesium hydroxide (MH)	281:310	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	1	44	theme	MCC-magnesium	283:295	arg1	MH					308:309	MH	308:309	MH	308:309	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	1	45	theme	metal	364:368	arg1	ion					377:379	heavy metal Co(II) ion	358:379	heavy metal Co(II) ion	358:379	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	5	46	theme	Co	1121:1122	arg1	adsorption					1107:1116	the adsorption	1103:1116	the adsorption of Co(II) by MCC-MH	1103:1136	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	5	46	theme	Co	1121:1122	arg1	reaction					1168:1175	a spontaneous endothermic reaction	1142:1175	a spontaneous endothermic reaction	1142:1175	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	4	47	theme	solution	813:820	arg1	rate					798:801	The removal rate	786:801	The removal rate of Co(II) solution by MCC-MH	786:830	The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.
34450150	4	47	theme	solution	813:820	arg1	high					839:842	high	839:842	high	839:842	The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.
34450150	3	48	theme	50 min	672:677	arg1	Co					682:683	a Co(II) solution pH of 6.0-8.0	680:710	a Co(II) solution pH of 6.0-8.0	680:710	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	48	theme	50 min	672:677	arg1	dosage					612:617	an MCC-MH dosage	602:617	an MCC-MH dosage of 2.5 mg/mL	602:630	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	48	theme	50 min	672:677	arg1	concentration					731:743	an initial Co(II) concentration	713:743	an initial Co(II) concentration of 300 mg/L	713:755	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	48	theme	50 min	672:677	arg1	time					664:667	a contact reaction equilibrium time	633:667	a contact reaction equilibrium time of 50 min	633:677	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	48	theme	50 min	672:677	arg1	temperature					764:774	a temperature	762:774	a temperature of 303 K	762:783	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	1	49	theme	Co	370:371	arg1	ion					377:379	heavy metal Co(II) ion	358:379	heavy metal Co(II) ion	358:379	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	3	50	theme	reaction	643:650	arg1	time					664:667	a contact reaction equilibrium time	633:667	a contact reaction equilibrium time of 50 min	633:677	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	51	theme	equilibrium	652:662	arg1	time					664:667	a contact reaction equilibrium time	633:667	a contact reaction equilibrium time of 50 min	633:677	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	6	52	theme	Analytical	1209:1218	arg1	studies					1220:1226	Analytical studies	1209:1226	Analytical studies	1209:1226	Analytical studies showed that Co(II) adsorption on MCC-MH composites is affected by chemical adsorption and involves the influence of intraparticle diffusion to a certain extent.
34450150	3	53	dep	Co	682:683	arg1	II					685:686	II	685:686	II	685:686	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	53	dep	Co	682:683	arg1	pH					698:699	solution pH	689:699	a Co(II) solution pH of 6.0-8.0	680:710	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	2	54	theme	adsorbent	476:484	arg1	dosages					486:492	adsorbent dosages	476:492	adsorbent dosages	476:492	The method of using MCC-MH to adsorb and remove Co(II) was studied under different pH values, adsorbent dosages, contact times, initial Co(II) ion concentrations, and temperatures.
34450150	3	55	theme	optimal	567:573	arg1	parameters					583:592	The optimal process parameters	563:592	The optimal process parameters	563:592	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	56	theme	303 K	779:783	arg1	Co					682:683	a Co(II) solution pH of 6.0-8.0	680:710	a Co(II) solution pH of 6.0-8.0	680:710	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	56	theme	303 K	779:783	arg1	dosage					612:617	an MCC-MH dosage	602:617	an MCC-MH dosage of 2.5 mg/mL	602:630	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	56	theme	303 K	779:783	arg1	concentration					731:743	an initial Co(II) concentration	713:743	an initial Co(II) concentration of 300 mg/L	713:755	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	56	theme	303 K	779:783	arg1	time					664:667	a contact reaction equilibrium time	633:667	a contact reaction equilibrium time of 50 min	633:677	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	56	theme	303 K	779:783	arg1	temperature					764:774	a temperature	762:774	a temperature of 303 K	762:783	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	5	57	theme	Co	1040:1041	arg1	data					1032:1035	the kinetic data	1020:1035	the kinetic data of Co(II)	1020:1045	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	6	58	theme	chemical	1294:1301	arg1	adsorption					1303:1312	chemical adsorption	1294:1312	chemical adsorption	1294:1312	Analytical studies showed that Co(II) adsorption on MCC-MH composites is affected by chemical adsorption and involves the influence of intraparticle diffusion to a certain extent.
34450150	1	59	theme	Microcrystalline	131:146	arg1	MCC					159:161	MCC	159:161	MCC	159:161	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	1	59	theme	Microcrystalline	131:146	arg1	cellulose					148:156	Microcrystalline cellulose	131:156	Microcrystalline cellulose (MCC)	131:162	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34450150	4	60	theme	maximum	863:869	arg1	capacity					882:889	the maximum adsorption capacity	859:889	the maximum adsorption capacity of MCC-MH	859:899	The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.
34450150	4	61	theme	optimal	933:939	arg1	conditions					941:950	these optimal conditions	927:950	these optimal conditions	927:950	The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.
34450150	3	62	theme	6.0-8.0	704:710	arg1	Co					682:683	a Co(II) solution pH of 6.0-8.0	680:710	a Co(II) solution pH of 6.0-8.0	680:710	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	62	theme	6.0-8.0	704:710	arg1	dosage					612:617	an MCC-MH dosage	602:617	an MCC-MH dosage of 2.5 mg/mL	602:630	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	62	theme	6.0-8.0	704:710	arg1	concentration					731:743	an initial Co(II) concentration	713:743	an initial Co(II) concentration of 300 mg/L	713:755	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	62	theme	6.0-8.0	704:710	arg1	time					664:667	a contact reaction equilibrium time	633:667	a contact reaction equilibrium time of 50 min	633:677	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	3	62	theme	6.0-8.0	704:710	arg1	temperature					764:774	a temperature	762:774	a temperature of 303 K	762:783	The optimal process parameters include an MCC-MH dosage of 2.5 mg/mL, a contact reaction equilibrium time of 50 min, a Co(II) solution pH of 6.0-8.0, an initial Co(II) concentration of 300 mg/L, and a temperature of 303 K.
34450150	5	63	theme	Langmuir	1004:1011	arg1	model					1013:1017	the Langmuir model	1000:1017	the Langmuir model	1000:1017	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	4	64	theme	removal	790:796	arg1	rate					798:801	The removal rate	786:801	The removal rate of Co(II) solution by MCC-MH	786:830	The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.
34450150	4	64	theme	removal	790:796	arg1	high					839:842	high	839:842	high	839:842	The removal rate of Co(II) solution by MCC-MH was as high as 97.67%, and the maximum adsorption capacity of MCC-MH reached 153.84 mg/g under these optimal conditions.
34450150	5	65	theme	kinetic	1084:1090	arg1	model					1092:1096	the pseudo-second-order kinetic model	1060:1096	the pseudo-second-order kinetic model	1060:1096	The adsorption isotherm of Co(II) conformed to the Langmuir model, the kinetic data of Co(II) conformed to the pseudo-second-order kinetic model, and the adsorption of Co(II) by MCC-MH was a spontaneous endothermic reaction under the optimized conditions.
34450150	6	66	theme	MCC-MH	1261:1266	arg1	composites					1268:1277	MCC-MH composites	1261:1277	MCC-MH composites	1261:1277	Analytical studies showed that Co(II) adsorption on MCC-MH composites is affected by chemical adsorption and involves the influence of intraparticle diffusion to a certain extent.
34450150	1	67	theme	ammonia	234:240	arg1	bath					242:245	ammonia bath	234:245	ammonia bath	234:245	Microcrystalline cellulose (MCC), magnesium sulfate hexahydrate, and trisodium citrate were reacted in ammonia bath in an aqueous solution to prepare a MCC-magnesium hydroxide (MH) composite adsorbent, which was used to adsorb heavy metal Co(II) ion.
34094453	4	0	theme	packing	873:879	arg1	component					791:799	the second component	780:799	the second component reflecting more restricted motion	780:833	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	4	0	theme	packing	873:879	arg1	reflective					836:845	reflective	836:845	reflective of increased crowding and packing within the glycocalyx	836:901	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	8	1	theme	results	1770:1776	arg1	interpretation					1748:1761	interpretation	1748:1761	interpretation of the results	1748:1776	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	3	2	theme	spin	483:486	arg1	labelling					488:496	spin labelling	483:496	spin labelling	483:496	Both sialic acid and N-acetylglucosamine (GlcNAc) were targeted for spin labelling.
34094453	1	3	theme	select	243:248	arg1	cancer					250:255	select cancer and normal cells	243:272	cancer	250:255	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	8	4	theme	glycocalyx	1903:1912	arg1	organization					1856:1867	local organization	1850:1867	local organization	1850:1867	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	8	4	theme	glycocalyx	1903:1912	arg1	heterogeneity					1873:1885	heterogeneity	1873:1885	heterogeneity	1873:1885	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	6	5	theme	sugar	1255:1259	arg1	moieties					1261:1268	sugar moieties	1255:1268	sugar moieties	1255:1268	These distinct environments are consistent with the organization of sugar moieties within cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile).
34094453	6	6	theme	cellular	1277:1284	arg1	glycans					1286:1292	cellular glycans	1277:1292	cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile)	1277:1447	These distinct environments are consistent with the organization of sugar moieties within cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile).
34094453	4	7	theme	heterogeneous	557:569	arg1	environment					578:588	a diverse and heterogeneous glycan environment	543:588	a diverse and heterogeneous glycan environment	543:588	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	7	8	theme	different	1462:1470	arg1	lines					1477:1481	different cell lines	1462:1481	different cell lines	1462:1481	Strikingly, different cell lines displayed varied relative populations of these two components, suggesting distinctive glycan packing, organization, and composition of different cells.
34094453	6	9	dep	restricted	1375:1384	arg1	i.e.					1365:1368	i.e.	1365:1368	i.e.	1365:1368	These distinct environments are consistent with the organization of sugar moieties within cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile).
34094453	4	10	theme	uncrowded	747:755	arg1	micro-environment					757:773	a highly mobile or uncrowded micro-environment	728:773	a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx	728:901	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	8	11	from	changes	1835:1841	arg1	organization					1856:1867	local organization	1850:1867	local organization	1850:1867	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	8	11	from	changes	1835:1841	arg1	heterogeneity					1873:1885	heterogeneity	1873:1885	heterogeneity	1873:1885	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	0	12	from	glycans	63:69	arg1	cells					74:78	cells	74:78	cells	74:78	A metabolically engineered spin-labeling approach for studying glycans on cells.
34094453	5	13	theme	relative	966:973	arg1	percentage					975:984	the relative percentage	962:984	the relative percentage of each component	962:1002	What differs among the spectra of the targeted glycans is the relative percentage of each component, with sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment.
34094453	4	14	theme	distinct	682:689	arg1	spectra					691:697	two distinct spectra	678:697	two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx	678:901	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	1	15	theme	nitroxide	129:137	arg1	SL					154:155	SL	154:155	SL	154:155	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	1	15	theme	nitroxide	129:137	arg1	spin-labeling					139:151	nitroxide spin-labeling	129:151	nitroxide spin-labeling (SL)	129:156	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	6	16	with	consistent	1219:1228	arg1	organization					1239:1250	the organization	1235:1250	the organization of sugar moieties within cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile)	1235:1447	These distinct environments are consistent with the organization of sugar moieties within cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile).
34094453	3	17	theme	sialic	420:425	arg1	acid					427:430	sialic acid	420:430	sialic acid	420:430	Both sialic acid and N-acetylglucosamine (GlcNAc) were targeted for spin labelling.
34094453	1	18	theme	normal	261:266	arg1	cells					268:272	select cancer and normal cells	243:272	cells	268:272	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	5	19	dep	average	1146:1152	arg1	environment					1174:1184	a ∼50% more crowded environment	1154:1184	average a ∼50% more crowded environment	1146:1184	What differs among the spectra of the targeted glycans is the relative percentage of each component, with sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment.
34094453	4	20	theme	glycan	571:576	arg1	environment					578:588	a diverse and heterogeneous glycan environment	543:588	a diverse and heterogeneous glycan environment	543:588	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	7	21	theme	distinctive	1557:1567	arg1	packing					1576:1582	distinctive glycan packing	1557:1582	distinctive glycan packing	1557:1582	Strikingly, different cell lines displayed varied relative populations of these two components, suggesting distinctive glycan packing, organization, and composition of different cells.
34094453	1	22	theme	Metabolic	81:89	arg1	engineering					98:108	Metabolic glycan engineering	81:108	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL)	81:156	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	1	22	theme	Metabolic	81:89	arg1	MGE					111:113	MGE	111:113	MGE	111:113	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	8	23	theme	local	1850:1854	arg1	organization					1856:1867	local organization	1850:1867	local organization	1850:1867	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	4	24	theme	diverse	545:551	arg1	environment					578:588	a diverse and heterogeneous glycan environment	543:588	a diverse and heterogeneous glycan environment	543:588	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	4	25	theme	crowding	860:867	arg1	component					791:799	the second component	780:799	the second component reflecting more restricted motion	780:833	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	4	25	theme	crowding	860:867	arg1	reflective					836:845	reflective	836:845	reflective of increased crowding and packing within the glycocalyx	836:901	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	1	26	theme	glycan	91:96	arg1	engineering					98:108	Metabolic glycan engineering	81:108	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL)	81:156	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	1	26	theme	glycan	91:96	arg1	MGE					111:113	MGE	111:113	MGE	111:113	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	6	27	dep	glycan	1423:1428	arg1	i.e.					1431:1434	i.e.	1431:1434	i.e. more mobile	1431:1446	These distinct environments are consistent with the organization of sugar moieties within cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile).
34094453	4	28	theme	linear	656:661	arg1	combination					663:673	a linear combination	654:673	a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx	654:901	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	4	28	theme	linear	656:661	arg1	spectra					601:607	their EPR spectra	591:607	their EPR spectra	591:607	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	4	28	theme	linear	656:661	arg1	mobility					619:626	mobility	619:626	mobility	619:626	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	6	29	theme	distinct	1193:1200	arg1	environments					1202:1213	These distinct environments	1187:1213	These distinct environments	1187:1213	These distinct environments are consistent with the organization of sugar moieties within cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile).
34094453	5	30	theme	more	1161:1164	arg1	environment					1174:1184	a ∼50% more crowded environment	1154:1184	average a ∼50% more crowded environment	1146:1184	What differs among the spectra of the targeted glycans is the relative percentage of each component, with sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment.
34094453	4	31	theme	increased	850:858	arg1	crowding					860:867	increased crowding	850:867	increased crowding	850:867	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	5	32	theme	targeted	942:949	arg1	glycans					951:957	the targeted glycans	938:957	the targeted glycans	938:957	What differs among the spectra of the targeted glycans is the relative percentage of each component, with sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment.
34094453	7	33	theme	relative	1500:1507	arg1	populations					1509:1519	varied relative populations	1493:1519	varied relative populations of these two components	1493:1543	Strikingly, different cell lines displayed varied relative populations of these two components, suggesting distinctive glycan packing, organization, and composition of different cells.
34094453	2	34	theme	click	367:371	arg1	reaction					373:380	a click reaction	365:380	a click reaction with a new nitroxide spin label	365:412	This approach exploited the incorporation of azides into cell surface glycans followed by a click reaction with a new nitroxide spin label.
34094453	0	35	theme	spin-labeling	27:39	arg1	approach					41:48	A metabolically engineered spin-labeling approach	0:48	A metabolically engineered spin-labeling approach for studying glycans on cells	0:78	A metabolically engineered spin-labeling approach for studying glycans on cells.
34094453	4	36	with	micro-environment	757:773	arg1	component					791:799	the second component	780:799	the second component reflecting more restricted motion	780:833	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	4	36	with	micro-environment	757:773	arg1	reflective					836:845	reflective	836:845	reflective of increased crowding and packing within the glycocalyx	836:901	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	4	37	theme	mobile	737:742	arg1	micro-environment					757:773	a highly mobile or uncrowded micro-environment	728:773	a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx	728:901	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	5	38	theme	sialic	1010:1015	arg1	moieties					1022:1029	sialic acid moieties	1010:1029	sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment	1010:1184	What differs among the spectra of the targeted glycans is the relative percentage of each component, with sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment.
34094453	0	39	theme	engineered	16:25	arg1	approach					41:48	A metabolically engineered spin-labeling approach	0:48	A metabolically engineered spin-labeling approach for studying glycans on cells	0:78	A metabolically engineered spin-labeling approach for studying glycans on cells.
34094453	7	40	theme	cells	1628:1632	arg1	organization					1585:1596	organization	1585:1596	organization	1585:1596	Strikingly, different cell lines displayed varied relative populations of these two components, suggesting distinctive glycan packing, organization, and composition of different cells.
34094453	7	40	theme	cells	1628:1632	arg1	composition					1603:1613	composition	1603:1613	composition	1603:1613	Strikingly, different cell lines displayed varied relative populations of these two components, suggesting distinctive glycan packing, organization, and composition of different cells.
34094453	7	40	theme	cells	1628:1632	arg1	packing					1576:1582	distinctive glycan packing	1557:1582	distinctive glycan packing	1557:1582	Strikingly, different cell lines displayed varied relative populations of these two components, suggesting distinctive glycan packing, organization, and composition of different cells.
34094453	6	41	theme	membrane/protein	1338:1353	arg1	backbone					1355:1362	the cell membrane/protein backbone	1329:1362	the cell membrane/protein backbone (i.e. more restricted)	1329:1385	These distinct environments are consistent with the organization of sugar moieties within cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile).
34094453	8	42	theme	useful	1701:1706	arg1	tool					1708:1711	a broadly useful tool	1691:1711	a broadly useful tool for studying glycans on cells	1691:1741	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	8	43	from	differences	1819:1829	arg1	organization					1856:1867	local organization	1850:1867	local organization	1850:1867	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	8	43	from	differences	1819:1829	arg1	heterogeneity					1873:1885	heterogeneity	1873:1885	heterogeneity	1873:1885	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	1	44	theme	heterogeneous	190:202	arg1	environment					204:214	the heterogeneous environment	186:214	the heterogeneous environment of cell surface glycans in select cancer and normal cells	186:272	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	5	45	with	percentage	975:984	arg1	moieties					1022:1029	sialic acid moieties	1010:1029	sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment	1010:1184	What differs among the spectra of the targeted glycans is the relative percentage of each component, with sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment.
34094453	4	46	theme	spectra	691:697	arg1	combination					663:673	a linear combination	654:673	a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx	654:901	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	4	46	theme	spectra	691:697	arg1	spectra					601:607	their EPR spectra	591:607	their EPR spectra	591:607	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	4	46	theme	spectra	691:697	arg1	mobility					619:626	mobility	619:626	mobility	619:626	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	6	47	theme	cell	1333:1336	arg1	backbone					1355:1362	the cell membrane/protein backbone	1329:1362	the cell membrane/protein backbone (i.e. more restricted)	1329:1385	These distinct environments are consistent with the organization of sugar moieties within cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile).
34094453	5	48	theme	less	1063:1066	arg1	environment					1076:1086	an ∼80% less crowded environment	1055:1086	an ∼80% less crowded environment	1055:1086	What differs among the spectra of the targeted glycans is the relative percentage of each component, with sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment.
34094453	4	49	theme	restricted	817:826	arg1	motion					828:833	more restricted motion	812:833	more restricted motion	812:833	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	2	50	theme	nitroxide	393:401	arg1	spin					403:406	a new nitroxide spin	387:406	a new nitroxide spin label	387:412	This approach exploited the incorporation of azides into cell surface glycans followed by a click reaction with a new nitroxide spin label.
34094453	6	51	theme	moieties	1261:1268	arg1	organization					1239:1250	the organization	1235:1250	the organization of sugar moieties within cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile)	1235:1447	These distinct environments are consistent with the organization of sugar moieties within cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile).
34094453	6	52	from	glycan	1423:1428	arg1	terminal					1407:1414	terminal	1407:1414	terminal	1407:1414	These distinct environments are consistent with the organization of sugar moieties within cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile).
34094453	7	53	theme	glycan	1569:1574	arg1	packing					1576:1582	distinctive glycan packing	1557:1582	distinctive glycan packing	1557:1582	Strikingly, different cell lines displayed varied relative populations of these two components, suggesting distinctive glycan packing, organization, and composition of different cells.
34094453	5	54	theme	crowded	1068:1074	arg1	environment					1076:1086	an ∼80% less crowded environment	1055:1086	an ∼80% less crowded environment	1055:1086	What differs among the spectra of the targeted glycans is the relative percentage of each component, with sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment.
34094453	5	55	theme	acid	1017:1020	arg1	moieties					1022:1029	sialic acid moieties	1010:1029	sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment	1010:1184	What differs among the spectra of the targeted glycans is the relative percentage of each component, with sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment.
34094453	1	56	from	environment	204:214	arg1	cancer					250:255	select cancer and normal cells	243:272	cancer	250:255	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	1	56	from	environment	204:214	arg1	cells					268:272	select cancer and normal cells	243:272	cells	268:272	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	2	57	theme	new	389:391	arg1	spin					403:406	a new nitroxide spin	387:406	a new nitroxide spin label	387:412	This approach exploited the incorporation of azides into cell surface glycans followed by a click reaction with a new nitroxide spin label.
34094453	7	58	theme	different	1618:1626	arg1	cells					1628:1632	different cells	1618:1632	different cells	1618:1632	Strikingly, different cell lines displayed varied relative populations of these two components, suggesting distinctive glycan packing, organization, and composition of different cells.
34094453	5	59	theme	crowded	1166:1172	arg1	environment					1174:1184	a ∼50% more crowded environment	1154:1184	average a ∼50% more crowded environment	1146:1184	What differs among the spectra of the targeted glycans is the relative percentage of each component, with sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment.
34094453	2	60	theme	surface	337:343	arg1	glycans					345:351	cell surface glycans	332:351	cell surface glycans followed by a click reaction with a new nitroxide spin label	332:412	This approach exploited the incorporation of azides into cell surface glycans followed by a click reaction with a new nitroxide spin label.
34094453	8	61	dep	organization	1856:1867	arg1	the					1846:1848	the	1846:1848	the	1846:1848	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	8	62	dep	differences	1819:1829	arg1	the					1815:1817	the	1815:1817	the	1815:1817	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	5	63	theme	labeled	1120:1126	arg1	sites					1128:1132	labeled sites	1120:1132	labeled sites reported on average a ∼50% more crowded environment	1120:1184	What differs among the spectra of the targeted glycans is the relative percentage of each component, with sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment.
34094453	6	64	from	terminal	1407:1414	arg1	glycan					1423:1428	the glycan	1419:1428	the glycan (i.e. more mobile)	1419:1447	These distinct environments are consistent with the organization of sugar moieties within cellular glycans where some residues occur close to the cell membrane/protein backbone (i.e. more restricted) and others are more terminal in the glycan (i.e. more mobile).
34094453	2	65	dep	spin	403:406	arg1	label					408:412	label	408:412	label	408:412	This approach exploited the incorporation of azides into cell surface glycans followed by a click reaction with a new nitroxide spin label.
34094453	8	66	theme	cellular	1894:1901	arg1	glycocalyx					1903:1912	the cellular glycocalyx	1890:1912	the cellular glycocalyx	1890:1912	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	2	67	theme	cell	332:335	arg1	glycans					345:351	cell surface glycans	332:351	cell surface glycans followed by a click reaction with a new nitroxide spin label	332:412	This approach exploited the incorporation of azides into cell surface glycans followed by a click reaction with a new nitroxide spin label.
34094453	7	68	theme	components	1534:1543	arg1	populations					1509:1519	varied relative populations	1493:1519	varied relative populations of these two components	1493:1543	Strikingly, different cell lines displayed varied relative populations of these two components, suggesting distinctive glycan packing, organization, and composition of different cells.
34094453	4	69	theme	second	784:789	arg1	component					791:799	the second component	780:799	the second component reflecting more restricted motion	780:833	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	4	69	theme	second	784:789	arg1	reflective					836:845	reflective	836:845	reflective of increased crowding and packing within the glycocalyx	836:901	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	5	70	theme	glycans	951:957	arg1	spectra					927:933	the spectra	923:933	the spectra of the targeted glycans	923:957	What differs among the spectra of the targeted glycans is the relative percentage of each component, with sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment.
34094453	1	71	theme	cell	219:222	arg1	glycans					232:238	cell surface glycans	219:238	cell surface glycans	219:238	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	5	72	theme	component	994:1002	arg1	percentage					975:984	the relative percentage	962:984	the relative percentage of each component	962:1002	What differs among the spectra of the targeted glycans is the relative percentage of each component, with sialic acid moieties experiencing on average an ∼80% less crowded environment, where conversely GlcNAc/GalNAz labeled sites reported on average a ∼50% more crowded environment.
34094453	2	73	theme	azides	320:325	arg1	incorporation					303:315	the incorporation	299:315	the incorporation of azides into cell surface glycans followed by a click reaction with a new nitroxide spin label	299:412	This approach exploited the incorporation of azides into cell surface glycans followed by a click reaction with a new nitroxide spin label.
34094453	1	74	theme	surface	224:230	arg1	glycans					232:238	cell surface glycans	219:238	cell surface glycans	219:238	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	7	75	theme	varied	1493:1498	arg1	populations					1509:1519	varied relative populations	1493:1519	varied relative populations of these two components	1493:1543	Strikingly, different cell lines displayed varied relative populations of these two components, suggesting distinctive glycan packing, organization, and composition of different cells.
34094453	1	76	used	utilized	162:169	arg2	MGE					111:113	MGE	111:113	MGE	111:113	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	1	76	used	utilized	162:169	arg2	engineering					98:108	Metabolic glycan engineering	81:108	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL)	81:156	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	8	77	theme	EPR	1681:1683	arg1	capability					1662:1671	the capability	1658:1671	the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells	1658:1741	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	1	78	theme	glycans	232:238	arg1	environment					204:214	the heterogeneous environment	186:214	the heterogeneous environment of cell surface glycans in select cancer and normal cells	186:272	Metabolic glycan engineering (MGE) coupled with nitroxide spin-labeling (SL) was utilized to investigate the heterogeneous environment of cell surface glycans in select cancer and normal cells.
34094453	8	79	from	glycans	1726:1732	arg1	cells					1737:1741	cells	1737:1741	cells	1737:1741	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	2	80	with	reaction	373:380	arg1	spin					403:406	a new nitroxide spin	387:406	a new nitroxide spin label	387:412	This approach exploited the incorporation of azides into cell surface glycans followed by a click reaction with a new nitroxide spin label.
34094453	4	81	dep	characterized	637:649	arg1	both					632:635	both	632:635	both	632:635	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	4	82	theme	EPR	597:599	arg1	combination					663:673	a linear combination	654:673	a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx	654:901	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	4	82	theme	EPR	597:599	arg1	spectra					601:607	their EPR spectra	591:607	their EPR spectra	591:607	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	4	82	theme	EPR	597:599	arg1	mobility					619:626	mobility	619:626	mobility	619:626	Although each of these moieties experiences a diverse and heterogeneous glycan environment, their EPR spectra and hence mobility are both characterized as a linear combination of two distinct spectra where one component reflects a highly mobile or uncrowded micro-environment with the second component reflecting more restricted motion, reflective of increased crowding and packing within the glycocalyx.
34094453	8	83	gly	heterogeneity	1873:1885	arg1	glycocalyx					1903:1912	the cellular glycocalyx	1890:1912	the cellular glycocalyx	1890:1912	This work demonstrates the capability of SDSL EPR to be a broadly useful tool for studying glycans on cells, and interpretation of the results provides insights for distinguishing the differences and changes in the local organization and heterogeneity of the cellular glycocalyx.
34094453	7	84	theme	cell	1472:1475	arg1	lines					1477:1481	different cell lines	1462:1481	different cell lines	1462:1481	Strikingly, different cell lines displayed varied relative populations of these two components, suggesting distinctive glycan packing, organization, and composition of different cells.
34665338	9	0	theme	food	1304:1307	arg1	packaging					1309:1317	potential food packaging and wound dressings	1294:1337	packaging	1309:1317	The present work introduces a facile green approach for BC/AgNP composite synthesis and its utility as potential food packaging and wound dressings, as well as sunlight indicator application.
34665338	9	1	theme	green	1228:1232	arg1	approach					1234:1241	a facile green approach	1219:1241	a facile green approach for BC/AgNP composite synthesis and its utility as potential food packaging and wound dressings, as well as sunlight indicator application	1219:1380	The present work introduces a facile green approach for BC/AgNP composite synthesis and its utility as potential food packaging and wound dressings, as well as sunlight indicator application.
34665338	2	2	dep	nanoparticles	438:450	arg1	Ago					453:455	Ago	453:455	Ago	453:455	The photochemical reduction of silver Ag + ions into silver nanoparticles (Ago) was confirmed using UV visible spectra; the surface plasmon resonance of synthesized AgNPs was localized around 425 nm.
34665338	3	3	theme	- 9.98 mV	673:681	arg1	value					664:668	a zeta potential value	647:668	a zeta potential value of - 9.98 mV	647:681	The mean diameter of AgNPs obtained by DLS analysis was 52.0 nm with a zeta potential value of - 9.98 mV.
34665338	6	4	from	structures	852:861	arg1	nanofibers					926:935	the BC crystalline nanofibers	907:935	the BC crystalline nanofibers	907:935	FESEM images for BC showed the 3D structures of BC nanofibers and the deposited AgNPs in the BC crystalline nanofibers.
34665338	1	5	theme	nanoparticles	224:236	arg1	synthesis					204:212	synthesis	204:212	synthesis of silver nanoparticles (AgNPs)	204:244	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34665338	2	6	theme	plasmon	510:516	arg1	resonance					518:526	the surface plasmon resonance	498:526	the surface plasmon resonance of synthesized AgNPs	498:547	The photochemical reduction of silver Ag + ions into silver nanoparticles (Ago) was confirmed using UV visible spectra; the surface plasmon resonance of synthesized AgNPs was localized around 425 nm.
34665338	9	7	theme	BC/AgNP	1247:1253	arg1	synthesis					1265:1273	BC/AgNP composite synthesis	1247:1273	BC/AgNP composite synthesis	1247:1273	The present work introduces a facile green approach for BC/AgNP composite synthesis and its utility as potential food packaging and wound dressings, as well as sunlight indicator application.
34665338	8	8	theme	Gram-positive	1149:1161	arg1	bacteria					1181:1188	both Gram-positive and Gram-negative bacteria	1144:1188	both Gram-positive and Gram-negative bacteria	1144:1188	BC/AgNP composite and AgNPs exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria.
34665338	9	9	theme	composite	1255:1263	arg1	synthesis					1265:1273	BC/AgNP composite synthesis	1247:1273	BC/AgNP composite synthesis	1247:1273	The present work introduces a facile green approach for BC/AgNP composite synthesis and its utility as potential food packaging and wound dressings, as well as sunlight indicator application.
34665338	7	10	theme	5.13	1037:1040	arg1	sizes					1028:1032	crystal sizes	1020:1032	crystal sizes of 5.13 and 5.6 nm	1020:1051	XRD measurements revealed the high crystallinity of BC and BC/AgNP composite with crystal sizes of 5.13 and 5.6 nm, respectively.
34665338	3	11	theme	zeta	649:652	arg1	value					664:668	a zeta potential value	647:668	a zeta potential value of - 9.98 mV	647:681	The mean diameter of AgNPs obtained by DLS analysis was 52.0 nm with a zeta potential value of - 9.98 mV.
34665338	9	12	theme	wound	1323:1327	arg1	dressings					1329:1337	potential food packaging and wound dressings	1294:1337	dressings	1329:1337	The present work introduces a facile green approach for BC/AgNP composite synthesis and its utility as potential food packaging and wound dressings, as well as sunlight indicator application.
34665338	9	13	theme	indicator	1360:1368	arg1	application					1370:1380	sunlight indicator application	1351:1380	sunlight indicator application	1351:1380	The present work introduces a facile green approach for BC/AgNP composite synthesis and its utility as potential food packaging and wound dressings, as well as sunlight indicator application.
34665338	8	14	theme	BC/AgNP	1068:1074	arg1	composite					1076:1084	BC/AgNP composite	1068:1084	BC/AgNP composite	1068:1084	BC/AgNP composite and AgNPs exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria.
34665338	1	15	theme	AgNO3	320:324	arg1	solution					326:333	AgNO3 solution	320:333	AgNO3 solution	320:333	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34665338	6	16	theme	crystalline	914:924	arg1	nanofibers					926:935	the BC crystalline nanofibers	907:935	the BC crystalline nanofibers	907:935	FESEM images for BC showed the 3D structures of BC nanofibers and the deposited AgNPs in the BC crystalline nanofibers.
34665338	2	17	theme	visible	481:487	arg1	spectra					489:495	UV visible spectra	478:495	UV visible spectra	478:495	The photochemical reduction of silver Ag + ions into silver nanoparticles (Ago) was confirmed using UV visible spectra; the surface plasmon resonance of synthesized AgNPs was localized around 425 nm.
34665338	6	18	theme	FESEM	818:822	arg1	images					824:829	FESEM images	818:829	FESEM images for BC	818:836	FESEM images for BC showed the 3D structures of BC nanofibers and the deposited AgNPs in the BC crystalline nanofibers.
34665338	5	19	theme	composite	755:763	arg1	formation					734:742	The formation	730:742	The formation of BC/AgNP composite	730:763	The formation of BC/AgNP composite was confirmed by FESEM, EDX, FTIR, and XRD analysis.
34665338	0	20	theme	reducing	111:118	arg1	agent					132:136	reducing and capping agent	111:136	agent	132:136	Solar radiation-induced synthesis of bacterial cellulose/silver nanoparticles (BC/AgNPs) composite using BC as reducing and capping agent.
34665338	6	21	theme	BC	911:912	arg1	nanofibers					926:935	the BC crystalline nanofibers	907:935	the BC crystalline nanofibers	907:935	FESEM images for BC showed the 3D structures of BC nanofibers and the deposited AgNPs in the BC crystalline nanofibers.
34665338	2	22	theme	Ag + ions	416:424	arg1	reduction					396:404	The photochemical reduction	378:404	The photochemical reduction of silver Ag + ions into silver nanoparticles (Ago)	378:456	The photochemical reduction of silver Ag + ions into silver nanoparticles (Ago) was confirmed using UV visible spectra; the surface plasmon resonance of synthesized AgNPs was localized around 425 nm.
34665338	3	23	with	52.0 nm	634:640	arg1	value					664:668	a zeta potential value	647:668	a zeta potential value of - 9.98 mV	647:681	The mean diameter of AgNPs obtained by DLS analysis was 52.0 nm with a zeta potential value of - 9.98 mV.
34665338	1	24	theme	simple	162:167	arg1	method					193:198	a simple, novel, and ecofriendly method	160:198	a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs)	160:244	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34665338	0	25	theme	radiation-induced	6:22	arg1	synthesis					24:32	Solar radiation-induced synthesis	0:32	Solar radiation-induced synthesis of bacterial cellulose/silver nanoparticles (BC/AgNPs)	0:87	Solar radiation-induced synthesis of bacterial cellulose/silver nanoparticles (BC/AgNPs) composite using BC as reducing and capping agent.
34665338	1	26	theme	induction	341:349	arg1	action					351:356	induction action	341:356	induction action of solar radiation	341:375	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34665338	7	27	theme	BC/AgNP	997:1003	arg1	composite					1005:1013	BC/AgNP composite	997:1013	BC/AgNP composite	997:1013	XRD measurements revealed the high crystallinity of BC and BC/AgNP composite with crystal sizes of 5.13 and 5.6 nm, respectively.
34665338	0	28	dep	using	99:103	arg1	composite					89:97	composite	89:97	composite	89:97	Solar radiation-induced synthesis of bacterial cellulose/silver nanoparticles (BC/AgNPs) composite using BC as reducing and capping agent.
34665338	7	29	theme	high	968:971	arg1	crystallinity					973:985	the high crystallinity	964:985	the high crystallinity of BC and BC/AgNP composite with crystal sizes of 5.13 and 5.6 nm	964:1051	XRD measurements revealed the high crystallinity of BC and BC/AgNP composite with crystal sizes of 5.13 and 5.6 nm, respectively.
34665338	0	30	theme	Solar	0:4	arg1	synthesis					24:32	Solar radiation-induced synthesis	0:32	Solar radiation-induced synthesis of bacterial cellulose/silver nanoparticles (BC/AgNPs)	0:87	Solar radiation-induced synthesis of bacterial cellulose/silver nanoparticles (BC/AgNPs) composite using BC as reducing and capping agent.
34665338	6	31	theme	deposited	888:896	arg1	AgNPs					898:902	the deposited AgNPs	884:902	the deposited AgNPs in the BC crystalline nanofibers	884:935	FESEM images for BC showed the 3D structures of BC nanofibers and the deposited AgNPs in the BC crystalline nanofibers.
34665338	7	32	theme	composite	1005:1013	arg1	crystallinity					973:985	the high crystallinity	964:985	the high crystallinity of BC and BC/AgNP composite with crystal sizes of 5.13 and 5.6 nm	964:1051	XRD measurements revealed the high crystallinity of BC and BC/AgNP composite with crystal sizes of 5.13 and 5.6 nm, respectively.
34665338	9	33	theme	facile	1221:1226	arg1	approach					1234:1241	a facile green approach	1219:1241	a facile green approach for BC/AgNP composite synthesis and its utility as potential food packaging and wound dressings, as well as sunlight indicator application	1219:1380	The present work introduces a facile green approach for BC/AgNP composite synthesis and its utility as potential food packaging and wound dressings, as well as sunlight indicator application.
34665338	1	34	theme	novel	170:174	arg1	method					193:198	a simple, novel, and ecofriendly method	160:198	a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs)	160:244	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34665338	2	35	theme	silver	409:414	arg1	Ag + ions					416:424	silver Ag + ions	409:424	silver Ag + ions	409:424	The photochemical reduction of silver Ag + ions into silver nanoparticles (Ago) was confirmed using UV visible spectra; the surface plasmon resonance of synthesized AgNPs was localized around 425 nm.
34665338	1	36	theme	BC/AgNP	250:256	arg1	composite					258:266	BC/AgNP composite	250:266	BC/AgNP composite	250:266	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34665338	7	37	theme	BC	990:991	arg1	crystallinity					973:985	the high crystallinity	964:985	the high crystallinity of BC and BC/AgNP composite with crystal sizes of 5.13 and 5.6 nm	964:1051	XRD measurements revealed the high crystallinity of BC and BC/AgNP composite with crystal sizes of 5.13 and 5.6 nm, respectively.
34665338	4	38	theme	spherical	704:712	arg1	shape					714:718	a spherical shape	702:718	a spherical shape of AgNPs	702:727	TEM images showed a spherical shape of AgNPs.
34665338	7	39	theme	crystal	1020:1026	arg1	sizes					1028:1032	crystal sizes	1020:1032	crystal sizes of 5.13 and 5.6 nm	1020:1051	XRD measurements revealed the high crystallinity of BC and BC/AgNP composite with crystal sizes of 5.13 and 5.6 nm, respectively.
34665338	7	40	with	crystallinity	973:985	arg1	sizes					1028:1032	crystal sizes	1020:1032	crystal sizes of 5.13 and 5.6 nm	1020:1051	XRD measurements revealed the high crystallinity of BC and BC/AgNP composite with crystal sizes of 5.13 and 5.6 nm, respectively.
34665338	8	41	theme	antibacterial	1113:1125	arg1	activity					1127:1134	strong antibacterial activity	1106:1134	strong antibacterial activity against both Gram-positive and Gram-negative bacteria	1106:1188	BC/AgNP composite and AgNPs exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria.
34665338	0	42	theme	capping	124:130	arg1	agent					132:136	reducing and capping agent	111:136	agent	132:136	Solar radiation-induced synthesis of bacterial cellulose/silver nanoparticles (BC/AgNPs) composite using BC as reducing and capping agent.
34665338	2	43	theme	photochemical	382:394	arg1	reduction					396:404	The photochemical reduction	378:404	The photochemical reduction of silver Ag + ions into silver nanoparticles (Ago)	378:456	The photochemical reduction of silver Ag + ions into silver nanoparticles (Ago) was confirmed using UV visible spectra; the surface plasmon resonance of synthesized AgNPs was localized around 425 nm.
34665338	0	44	theme	cellulose/silver	47:62	arg1	BC/AgNPs					79:86	BC/AgNPs	79:86	BC/AgNPs	79:86	Solar radiation-induced synthesis of bacterial cellulose/silver nanoparticles (BC/AgNPs) composite using BC as reducing and capping agent.
34665338	0	44	theme	cellulose/silver	47:62	arg1	nanoparticles					64:76	bacterial cellulose/silver nanoparticles	37:76	bacterial cellulose/silver nanoparticles (BC/AgNPs)	37:87	Solar radiation-induced synthesis of bacterial cellulose/silver nanoparticles (BC/AgNPs) composite using BC as reducing and capping agent.
34665338	1	45	dep	nanofibers	299:308	arg1	soaked					310:315	soaked	310:315	nanofibers soaked in AgNO3 solution under induction action of solar radiation	299:375	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34665338	2	46	theme	surface	502:508	arg1	resonance					518:526	the surface plasmon resonance	498:526	the surface plasmon resonance of synthesized AgNPs	498:547	The photochemical reduction of silver Ag + ions into silver nanoparticles (Ago) was confirmed using UV visible spectra; the surface plasmon resonance of synthesized AgNPs was localized around 425 nm.
34665338	3	47	theme	DLS	617:619	arg1	analysis					621:628	DLS analysis	617:628	DLS analysis	617:628	The mean diameter of AgNPs obtained by DLS analysis was 52.0 nm with a zeta potential value of - 9.98 mV.
34665338	6	48	theme	nanofibers	869:878	arg1	AgNPs					898:902	the deposited AgNPs	884:902	the deposited AgNPs in the BC crystalline nanofibers	884:935	FESEM images for BC showed the 3D structures of BC nanofibers and the deposited AgNPs in the BC crystalline nanofibers.
34665338	6	48	theme	nanofibers	869:878	arg1	structures					852:861	the 3D structures	845:861	the 3D structures of BC nanofibers	845:878	FESEM images for BC showed the 3D structures of BC nanofibers and the deposited AgNPs in the BC crystalline nanofibers.
34665338	5	49	theme	XRD	804:806	arg1	analysis					808:815	XRD analysis	804:815	XRD analysis	804:815	The formation of BC/AgNP composite was confirmed by FESEM, EDX, FTIR, and XRD analysis.
34665338	0	50	theme	bacterial	37:45	arg1	BC/AgNPs					79:86	BC/AgNPs	79:86	BC/AgNPs	79:86	Solar radiation-induced synthesis of bacterial cellulose/silver nanoparticles (BC/AgNPs) composite using BC as reducing and capping agent.
34665338	0	50	theme	bacterial	37:45	arg1	nanoparticles					64:76	bacterial cellulose/silver nanoparticles	37:76	bacterial cellulose/silver nanoparticles (BC/AgNPs)	37:87	Solar radiation-induced synthesis of bacterial cellulose/silver nanoparticles (BC/AgNPs) composite using BC as reducing and capping agent.
34665338	1	51	theme	bacterial	274:282	arg1	cellulose					284:292	bacterial cellulose	274:292	bacterial cellulose (BC)	274:297	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34665338	1	51	theme	bacterial	274:282	arg1	BC					295:296	BC	295:296	BC	295:296	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34665338	9	52	theme	sunlight	1351:1358	arg1	application					1370:1380	sunlight indicator application	1351:1380	sunlight indicator application	1351:1380	The present work introduces a facile green approach for BC/AgNP composite synthesis and its utility as potential food packaging and wound dressings, as well as sunlight indicator application.
34665338	1	53	theme	solar	361:365	arg1	radiation					367:375	solar radiation	361:375	solar radiation	361:375	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34665338	2	54	theme	UV	478:479	arg1	spectra					489:495	UV visible spectra	478:495	UV visible spectra	478:495	The photochemical reduction of silver Ag + ions into silver nanoparticles (Ago) was confirmed using UV visible spectra; the surface plasmon resonance of synthesized AgNPs was localized around 425 nm.
34665338	7	55	theme	5.6 nm	1046:1051	arg1	sizes					1028:1032	crystal sizes	1020:1032	crystal sizes of 5.13 and 5.6 nm	1020:1051	XRD measurements revealed the high crystallinity of BC and BC/AgNP composite with crystal sizes of 5.13 and 5.6 nm, respectively.
34665338	6	56	theme	BC	866:867	arg1	nanofibers					869:878	BC nanofibers	866:878	BC nanofibers	866:878	FESEM images for BC showed the 3D structures of BC nanofibers and the deposited AgNPs in the BC crystalline nanofibers.
34665338	5	57	theme	BC/AgNP	747:753	arg1	composite					755:763	BC/AgNP composite	747:763	BC/AgNP composite	747:763	The formation of BC/AgNP composite was confirmed by FESEM, EDX, FTIR, and XRD analysis.
34665338	1	58	theme	radiation	367:375	arg1	action					351:356	induction action	341:356	induction action of solar radiation	341:375	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34665338	7	59	theme	XRD	938:940	arg1	measurements					942:953	XRD measurements	938:953	XRD measurements	938:953	XRD measurements revealed the high crystallinity of BC and BC/AgNP composite with crystal sizes of 5.13 and 5.6 nm, respectively.
34665338	0	60	theme	nanoparticles	64:76	arg1	synthesis					24:32	Solar radiation-induced synthesis	0:32	Solar radiation-induced synthesis of bacterial cellulose/silver nanoparticles (BC/AgNPs)	0:87	Solar radiation-induced synthesis of bacterial cellulose/silver nanoparticles (BC/AgNPs) composite using BC as reducing and capping agent.
34665338	9	61	theme	present	1195:1201	arg1	work					1203:1206	The present work	1191:1206	The present work	1191:1206	The present work introduces a facile green approach for BC/AgNP composite synthesis and its utility as potential food packaging and wound dressings, as well as sunlight indicator application.
34665338	2	62	theme	AgNPs	543:547	arg1	resonance					518:526	the surface plasmon resonance	498:526	the surface plasmon resonance of synthesized AgNPs	498:547	The photochemical reduction of silver Ag + ions into silver nanoparticles (Ago) was confirmed using UV visible spectra; the surface plasmon resonance of synthesized AgNPs was localized around 425 nm.
34665338	2	63	theme	silver	431:436	arg1	nanoparticles					438:450	silver nanoparticles	431:450	silver nanoparticles (Ago)	431:456	The photochemical reduction of silver Ag + ions into silver nanoparticles (Ago) was confirmed using UV visible spectra; the surface plasmon resonance of synthesized AgNPs was localized around 425 nm.
34665338	6	64	from	AgNPs	898:902	arg1	nanofibers					926:935	the BC crystalline nanofibers	907:935	the BC crystalline nanofibers	907:935	FESEM images for BC showed the 3D structures of BC nanofibers and the deposited AgNPs in the BC crystalline nanofibers.
34665338	3	65	theme	AgNPs	599:603	arg1	52.0 nm					634:640	52.0 nm	634:640	52.0 nm	634:640	The mean diameter of AgNPs obtained by DLS analysis was 52.0 nm with a zeta potential value of - 9.98 mV.
34665338	3	65	theme	AgNPs	599:603	arg1	diameter					587:594	The mean diameter	578:594	The mean diameter of AgNPs obtained by DLS analysis	578:628	The mean diameter of AgNPs obtained by DLS analysis was 52.0 nm with a zeta potential value of - 9.98 mV.
34665338	6	66	theme	3D	849:850	arg1	structures					852:861	the 3D structures	845:861	the 3D structures of BC nanofibers	845:878	FESEM images for BC showed the 3D structures of BC nanofibers and the deposited AgNPs in the BC crystalline nanofibers.
34665338	2	67	theme	synthesized	531:541	arg1	AgNPs					543:547	synthesized AgNPs	531:547	synthesized AgNPs	531:547	The photochemical reduction of silver Ag + ions into silver nanoparticles (Ago) was confirmed using UV visible spectra; the surface plasmon resonance of synthesized AgNPs was localized around 425 nm.
34665338	9	68	theme	potential	1294:1302	arg1	packaging					1309:1317	potential food packaging and wound dressings	1294:1337	packaging	1309:1317	The present work introduces a facile green approach for BC/AgNP composite synthesis and its utility as potential food packaging and wound dressings, as well as sunlight indicator application.
34665338	4	69	theme	TEM	684:686	arg1	images					688:693	TEM images	684:693	TEM images	684:693	TEM images showed a spherical shape of AgNPs.
34665338	4	70	theme	AgNPs	723:727	arg1	shape					714:718	a spherical shape	702:718	a spherical shape of AgNPs	702:727	TEM images showed a spherical shape of AgNPs.
34665338	8	71	theme	strong	1106:1111	arg1	activity					1127:1134	strong antibacterial activity	1106:1134	strong antibacterial activity against both Gram-positive and Gram-negative bacteria	1106:1188	BC/AgNP composite and AgNPs exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria.
34665338	8	72	theme	Gram-negative	1167:1179	arg1	bacteria					1181:1188	both Gram-positive and Gram-negative bacteria	1144:1188	both Gram-positive and Gram-negative bacteria	1144:1188	BC/AgNP composite and AgNPs exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria.
34665338	3	73	theme	potential	654:662	arg1	value					664:668	a zeta potential value	647:668	a zeta potential value of - 9.98 mV	647:681	The mean diameter of AgNPs obtained by DLS analysis was 52.0 nm with a zeta potential value of - 9.98 mV.
34665338	3	74	theme	mean	582:585	arg1	52.0 nm					634:640	52.0 nm	634:640	52.0 nm	634:640	The mean diameter of AgNPs obtained by DLS analysis was 52.0 nm with a zeta potential value of - 9.98 mV.
34665338	3	74	theme	mean	582:585	arg1	diameter					587:594	The mean diameter	578:594	The mean diameter of AgNPs obtained by DLS analysis	578:628	The mean diameter of AgNPs obtained by DLS analysis was 52.0 nm with a zeta potential value of - 9.98 mV.
34665338	1	75	theme	present	146:152	arg1	work					154:157	the present work	142:157	the present work	142:157	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34665338	1	76	theme	silver	217:222	arg1	AgNPs					239:243	AgNPs	239:243	AgNPs	239:243	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34665338	1	76	theme	silver	217:222	arg1	nanoparticles					224:236	silver nanoparticles	217:236	silver nanoparticles (AgNPs)	217:244	In the present work, a simple, novel, and ecofriendly method for synthesis of silver nanoparticles (AgNPs) and BC/AgNP composite using bacterial cellulose (BC) nanofibers soaked in AgNO3 solution under induction action of solar radiation.
34730340	0	0	theme	Charcoal	96:103	arg1	Conditioner					110:120	a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner	56:120	a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner	56:120	Integrated Instillation Technology for the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner for Controlled Release of Humic Acid and Soil Remediation.
34730340	1	1	theme	composite	330:338	arg1	material					340:347	a composite material	328:347	a composite material of sodium alginate (SA)	328:371	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	6	2	contain	has	1077:1079	arg2	value					1099:1103	a great potential value	1081:1103	a great potential value for improving soil conditions and promoting crop growth in agricultural applications	1081:1188	Therefore, the prepared soil conditioner has a great potential value for improving soil conditions and promoting crop growth in agricultural applications.
34730340	6	2	contain	has	1077:1079	arg1	conditioner					1065:1075	the prepared soil conditioner	1047:1075	the prepared soil conditioner	1047:1075	Therefore, the prepared soil conditioner has a great potential value for improving soil conditions and promoting crop growth in agricultural applications.
34730340	1	3	theme	acid	253:256	arg1	release					236:242	controlled release	225:242	controlled release of humic acid (CSGCHs)	225:265	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	0	4	theme	Alginate/Biomass	79:94	arg1	Conditioner					110:120	a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner	56:120	a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner	56:120	Integrated Instillation Technology for the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner for Controlled Release of Humic Acid and Soil Remediation.
34730340	1	5	theme	material	340:347	arg1	carrier					414:420	a carrier	412:420	a carrier	412:420	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	1	5	theme	material	340:347	arg1	CAC					404:406	CAC	404:406	CAC	404:406	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	1	5	theme	material	340:347	arg1	carbon					396:401	a composite material of sodium alginate (SA) and charcoal activated carbon	328:401	a composite material of sodium alginate (SA) and charcoal activated carbon (CAC)	328:407	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	6	6	from	growth	1154:1159	arg1	applications					1177:1188	agricultural applications	1164:1188	agricultural applications	1164:1188	Therefore, the prepared soil conditioner has a great potential value for improving soil conditions and promoting crop growth in agricultural applications.
34730340	5	7	theme	crops	1029:1033	arg1	growth					1019:1024	the growth	1015:1024	the growth of crops	1015:1033	The plant experiment showed that CSGCH could effectively promote the growth of crops.
34730340	4	8	from	content	787:793	arg1	soil					834:837	the soil	830:837	the soil	830:837	After 50 days of remediation, the content of nutrients and organic matter in the soil increased significantly and the pH and salt content of saline soils decreased by 15.2 and 29.8%, respectively.
34730340	0	9	theme	Conditioner	110:120	arg1	Synthesis					43:51	the Synthesis	39:51	the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner	39:120	Integrated Instillation Technology for the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner for Controlled Release of Humic Acid and Soil Remediation.
34730340	0	10	theme	Soil	105:108	arg1	Conditioner					110:120	a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner	56:120	a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner	56:120	Integrated Instillation Technology for the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner for Controlled Release of Humic Acid and Soil Remediation.
34730340	1	11	theme	sodium	352:357	arg1	alginate					359:366	sodium alginate	352:366	sodium alginate (SA)	352:371	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	1	11	theme	sodium	352:357	arg1	SA					369:370	SA	369:370	SA	369:370	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	2	12	theme	prepared	564:571	arg1	CSGCH					573:577	the prepared CSGCH	560:577	the prepared CSGCH	560:577	The results showed that the prepared CSGCH was uniform in size with obvious base responsiveness.
34730340	6	13	theme	soil	1119:1122	arg1	conditions					1124:1133	soil conditions	1119:1133	soil conditions	1119:1133	Therefore, the prepared soil conditioner has a great potential value for improving soil conditions and promoting crop growth in agricultural applications.
34730340	6	14	theme	prepared	1051:1058	arg1	conditioner					1065:1075	the prepared soil conditioner	1047:1075	the prepared soil conditioner	1047:1075	Therefore, the prepared soil conditioner has a great potential value for improving soil conditions and promoting crop growth in agricultural applications.
34730340	0	15	theme	Controlled	126:135	arg1	Release					137:143	Controlled Release	126:143	Controlled Release of Humic Acid and Soil Remediation	126:178	Integrated Instillation Technology for the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner for Controlled Release of Humic Acid and Soil Remediation.
34730340	1	16	theme	alginate	359:366	arg1	material					340:347	a composite material	328:347	a composite material of sodium alginate (SA)	328:371	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	1	16	theme	alginate	359:366	arg1	charcoal					377:384	charcoal	377:384	charcoal	377:384	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	2	17	theme	obvious	604:610	arg1	responsiveness					617:630	obvious base responsiveness	604:630	obvious base responsiveness	604:630	The results showed that the prepared CSGCH was uniform in size with obvious base responsiveness.
34730340	2	18	theme	base	612:615	arg1	responsiveness					617:630	obvious base responsiveness	604:630	obvious base responsiveness	604:630	The results showed that the prepared CSGCH was uniform in size with obvious base responsiveness.
34730340	3	19	theme	good	695:698	arg1	role					700:703	a good role	693:703	a good role	693:703	Soil remediation experiments revealed that CSGCH could play a good role in the remediation of different types of soils.
34730340	4	20	theme	nutrients	798:806	arg1	content					787:793	the content	783:793	the content of nutrients and organic matter in the soil	783:837	After 50 days of remediation, the content of nutrients and organic matter in the soil increased significantly and the pH and salt content of saline soils decreased by 15.2 and 29.8%, respectively.
34730340	0	21	theme	Instillation	11:22	arg1	Technology					24:33	Instillation Technology	11:33	Instillation Technology for the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner for Controlled Release of Humic Acid and Soil Remediation	11:178	Integrated Instillation Technology for the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner for Controlled Release of Humic Acid and Soil Remediation.
34730340	4	22	theme	matter	820:825	arg1	content					787:793	the content	783:793	the content of nutrients and organic matter in the soil	783:837	After 50 days of remediation, the content of nutrients and organic matter in the soil increased significantly and the pH and salt content of saline soils decreased by 15.2 and 29.8%, respectively.
34730340	4	23	dep	pH	871:872	arg1	the					867:869	the	867:869	the	867:869	After 50 days of remediation, the content of nutrients and organic matter in the soil increased significantly and the pH and salt content of saline soils decreased by 15.2 and 29.8%, respectively.
34730340	4	24	theme	soils	901:905	arg1	content					883:889	the pH and salt content	867:889	the pH and salt content of saline soils	867:905	After 50 days of remediation, the content of nutrients and organic matter in the soil increased significantly and the pH and salt content of saline soils decreased by 15.2 and 29.8%, respectively.
34730340	3	25	theme	different	727:735	arg1	types					737:741	different types	727:741	different types of soils	727:750	Soil remediation experiments revealed that CSGCH could play a good role in the remediation of different types of soils.
34730340	4	26	theme	organic	812:818	arg1	matter					820:825	organic matter	812:825	organic matter	812:825	After 50 days of remediation, the content of nutrients and organic matter in the soil increased significantly and the pH and salt content of saline soils decreased by 15.2 and 29.8%, respectively.
34730340	1	27	theme	slow-release	433:444	arg1	performance					446:456	their slow-release performance	427:456	their slow-release performance	427:456	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	6	28	theme	potential	1089:1097	arg1	value					1099:1103	a great potential value	1081:1103	a great potential value for improving soil conditions and promoting crop growth in agricultural applications	1081:1188	Therefore, the prepared soil conditioner has a great potential value for improving soil conditions and promoting crop growth in agricultural applications.
34730340	3	29	theme	types	737:741	arg1	remediation					712:722	the remediation	708:722	the remediation of different types of soils	708:750	Soil remediation experiments revealed that CSGCH could play a good role in the remediation of different types of soils.
34730340	4	30	theme	salt	878:881	arg1	content					883:889	the pH and salt content	867:889	the pH and salt content of saline soils	867:905	After 50 days of remediation, the content of nutrients and organic matter in the soil increased significantly and the pH and salt content of saline soils decreased by 15.2 and 29.8%, respectively.
34730340	6	31	theme	great	1083:1087	arg1	value					1099:1103	a great potential value	1081:1103	a great potential value for improving soil conditions and promoting crop growth in agricultural applications	1081:1188	Therefore, the prepared soil conditioner has a great potential value for improving soil conditions and promoting crop growth in agricultural applications.
34730340	1	32	theme	pH-responsive	195:207	arg1	spheres					213:219	pH-responsive gel spheres	195:219	pH-responsive gel spheres for controlled release of humic acid (CSGCHs)	195:265	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	1	33	theme	gel	209:211	arg1	spheres					213:219	pH-responsive gel spheres	195:219	pH-responsive gel spheres for controlled release of humic acid (CSGCHs)	195:265	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	0	34	theme	Acid	154:157	arg1	Release					137:143	Controlled Release	126:143	Controlled Release of Humic Acid and Soil Remediation	126:178	Integrated Instillation Technology for the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner for Controlled Release of Humic Acid and Soil Remediation.
34730340	3	35	theme	Soil	633:636	arg1	experiments					650:660	Soil remediation experiments	633:660	Soil remediation experiments	633:660	Soil remediation experiments revealed that CSGCH could play a good role in the remediation of different types of soils.
34730340	5	36	theme	plant	954:958	arg1	experiment					960:969	The plant experiment	950:969	The plant experiment	950:969	The plant experiment showed that CSGCH could effectively promote the growth of crops.
34730340	1	37	theme	integrated	287:296	arg1	technology					311:320	an integrated instillation technology	284:320	an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier	284:420	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	0	38	theme	Humic	148:152	arg1	Acid					154:157	Humic Acid	148:157	Humic Acid	148:157	Integrated Instillation Technology for the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner for Controlled Release of Humic Acid and Soil Remediation.
34730340	1	39	theme	charcoal	377:384	arg1	carrier					414:420	a carrier	412:420	a carrier	412:420	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	1	39	theme	charcoal	377:384	arg1	CAC					404:406	CAC	404:406	CAC	404:406	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	1	39	theme	charcoal	377:384	arg1	carbon					396:401	a composite material of sodium alginate (SA) and charcoal activated carbon	328:401	a composite material of sodium alginate (SA) and charcoal activated carbon (CAC)	328:407	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	1	40	theme	instillation	298:309	arg1	technology					311:320	an integrated instillation technology	284:320	an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier	284:420	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	0	41	theme	Soil	163:166	arg1	Remediation					168:178	Soil Remediation	163:178	Soil Remediation	163:178	Integrated Instillation Technology for the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner for Controlled Release of Humic Acid and Soil Remediation.
34730340	1	42	theme	activated	386:394	arg1	carrier					414:420	a carrier	412:420	a carrier	412:420	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	1	42	theme	activated	386:394	arg1	CAC					404:406	CAC	404:406	CAC	404:406	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	1	42	theme	activated	386:394	arg1	carbon					396:401	a composite material of sodium alginate (SA) and charcoal activated carbon	328:401	a composite material of sodium alginate (SA) and charcoal activated carbon (CAC)	328:407	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	6	43	theme	agricultural	1164:1175	arg1	applications					1177:1188	agricultural applications	1164:1188	agricultural applications	1164:1188	Therefore, the prepared soil conditioner has a great potential value for improving soil conditions and promoting crop growth in agricultural applications.
34730340	1	44	theme	pH-responsive	459:471	arg1	performance					473:483	pH-responsive performance	459:483	pH-responsive performance	459:483	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	3	45	theme	soils	746:750	arg1	types					737:741	different types	727:741	different types of soils	727:750	Soil remediation experiments revealed that CSGCH could play a good role in the remediation of different types of soils.
34730340	4	46	theme	pH	871:872	arg1	content					883:889	the pH and salt content	867:889	the pH and salt content of saline soils	867:905	After 50 days of remediation, the content of nutrients and organic matter in the soil increased significantly and the pH and salt content of saline soils decreased by 15.2 and 29.8%, respectively.
34730340	6	47	theme	soil	1060:1063	arg1	conditioner					1065:1075	the prepared soil conditioner	1047:1075	the prepared soil conditioner	1047:1075	Therefore, the prepared soil conditioner has a great potential value for improving soil conditions and promoting crop growth in agricultural applications.
34730340	1	48	theme	controlled	225:234	arg1	release					236:242	controlled release	225:242	controlled release of humic acid (CSGCHs)	225:265	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	0	49	theme	Remediation	168:178	arg1	Release					137:143	Controlled Release	126:143	Controlled Release of Humic Acid and Soil Remediation	126:178	Integrated Instillation Technology for the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner for Controlled Release of Humic Acid and Soil Remediation.
34730340	3	50	theme	remediation	638:648	arg1	experiments					650:660	Soil remediation experiments	633:660	Soil remediation experiments	633:660	Soil remediation experiments revealed that CSGCH could play a good role in the remediation of different types of soils.
34730340	6	51	theme	crop	1149:1152	arg1	growth					1154:1159	crop growth	1149:1159	crop growth in agricultural applications	1149:1188	Therefore, the prepared soil conditioner has a great potential value for improving soil conditions and promoting crop growth in agricultural applications.
34730340	4	52	theme	saline	894:899	arg1	soils					901:905	saline soils	894:905	saline soils	894:905	After 50 days of remediation, the content of nutrients and organic matter in the soil increased significantly and the pH and salt content of saline soils decreased by 15.2 and 29.8%, respectively.
34730340	0	53	theme	Sodium	72:77	arg1	Conditioner					110:120	a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner	56:120	a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner	56:120	Integrated Instillation Technology for the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner for Controlled Release of Humic Acid and Soil Remediation.
34730340	4	54	theme	remediation	770:780	arg1	days					762:765	50 days	759:765	50 days of remediation	759:780	After 50 days of remediation, the content of nutrients and organic matter in the soil increased significantly and the pH and salt content of saline soils decreased by 15.2 and 29.8%, respectively.
34730340	1	55	theme	soil	490:493	arg1	performance					505:515	soil amendment performance	490:515	soil amendment performance	490:515	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	0	56	theme	pH-Responsive	58:70	arg1	Conditioner					110:120	a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner	56:120	a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner	56:120	Integrated Instillation Technology for the Synthesis of a pH-Responsive Sodium Alginate/Biomass Charcoal Soil Conditioner for Controlled Release of Humic Acid and Soil Remediation.
34730340	1	57	theme	amendment	495:503	arg1	performance					505:515	soil amendment performance	490:515	soil amendment performance	490:515	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	1	58	theme	humic	247:251	arg1	CSGCHs					259:264	CSGCHs	259:264	CSGCHs	259:264	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34730340	1	58	theme	humic	247:251	arg1	acid					253:256	humic acid	247:256	humic acid (CSGCHs)	247:265	In this work, pH-responsive gel spheres for controlled release of humic acid (CSGCHs) were prepared by an integrated instillation technology using a composite material of sodium alginate (SA) and charcoal activated carbon (CAC) as a carrier, and their slow-release performance, pH-responsive performance, and soil amendment performance were investigated.
34896419	2	0	theme	aqueous	423:429	arg1	solution					431:438	aqueous solution	423:438	aqueous solution	423:438	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	8	1	theme	CHKB	1348:1351	arg1	fantastic					1355:1363	CHKB a fantastic	1348:1363	CHKB a fantastic	1348:1363	Excellent adsorption performance, low cost, and environmental-friendliness made CHKB a fantastic adsorbent for the removal of Cd (II) in wastewater.
34896419	1	2	from	biochar	165:171	arg1	Production					93:102	Production	93:102	Production of cost-efficient composite materials from low-cost modified biochar for the removal of Cd (II) from wastewater	93:214	Production of cost-efficient composite materials from low-cost modified biochar for the removal of Cd (II) from wastewater is much needed to meet the growing needs of industrial wastewater treatments.
34896419	2	3	theme	branch	325:330	arg1	CHKB					341:344	CHKB	341:344	CHKB	341:344	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	2	3	theme	branch	325:330	arg1	biochar					332:338	A novel chitosan-modified kiwi branch biochar	294:338	A novel chitosan-modified kiwi branch biochar (CHKB)	294:345	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	2	3	theme	branch	325:330	arg1	biochar					383:389	low-cost modified biochar	365:389	low-cost modified biochar for the removal of Cd (II) from aqueous solution	365:438	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	1	4	theme	low-cost	147:154	arg1	biochar					165:171	low-cost modified biochar	147:171	low-cost modified biochar for the removal of Cd (II) from wastewater	147:214	Production of cost-efficient composite materials from low-cost modified biochar for the removal of Cd (II) from wastewater is much needed to meet the growing needs of industrial wastewater treatments.
34896419	0	5	theme	kiwi	72:75	arg1	biochar					84:90	kiwi branch biochar	72:90	kiwi branch biochar	72:90	Efficient removal of Cd (II) from aqueous solution by chitosan modified kiwi branch biochar.
34896419	1	6	dep	the	239:241	arg1	needs					251:255	needs	251:255	needs	251:255	Production of cost-efficient composite materials from low-cost modified biochar for the removal of Cd (II) from wastewater is much needed to meet the growing needs of industrial wastewater treatments.
34896419	4	7	theme	monolayer	806:814	arg1	process					816:822	a monolayer process	804:822	a monolayer process controlled by chemisorption	804:850	The results revealed that the adsorption isotherms can be best described by a Langmuir model and that a pseudo-second-order model fits the Cd (II) adsorption kinetics well, which indicates that it is a monolayer process controlled by chemisorption.
34896419	4	7	theme	monolayer	806:814	arg1	it					798:799	it	798:799	it	798:799	The results revealed that the adsorption isotherms can be best described by a Langmuir model and that a pseudo-second-order model fits the Cd (II) adsorption kinetics well, which indicates that it is a monolayer process controlled by chemisorption.
34896419	4	8	theme	pseudo-second-order	708:726	arg1	model					728:732	a pseudo-second-order model	706:732	a pseudo-second-order model	706:732	The results revealed that the adsorption isotherms can be best described by a Langmuir model and that a pseudo-second-order model fits the Cd (II) adsorption kinetics well, which indicates that it is a monolayer process controlled by chemisorption.
34896419	4	9	dep	fits	734:737	arg1	indicates					783:791	indicates	783:791	indicates that it is a monolayer process controlled by chemisorption	783:850	The results revealed that the adsorption isotherms can be best described by a Langmuir model and that a pseudo-second-order model fits the Cd (II) adsorption kinetics well, which indicates that it is a monolayer process controlled by chemisorption.
34896419	5	10	theme	Cd	910:911	arg1	capacity					898:905	a Langmuir maximum adsorption capacity	868:905	a Langmuir maximum adsorption capacity of Cd (II) (126.58 mg g-1)	868:932	CHKB exhibited a Langmuir maximum adsorption capacity of Cd (II) (126.58 mg g-1), whereas that of KB was only 4.26 mg g-1.
34896419	8	11	from	Cd	1394:1395	arg1	wastewater					1405:1414	wastewater	1405:1414	wastewater	1405:1414	Excellent adsorption performance, low cost, and environmental-friendliness made CHKB a fantastic adsorbent for the removal of Cd (II) in wastewater.
34896419	3	12	theme	Batch	441:445	arg1	experiments					479:489	Batch adsorption and characterization experiments	441:489	Batch adsorption and characterization experiments	441:489	Batch adsorption and characterization experiments indicated that the modification of kiwi biochar (KB) by chitosan remarkably improved its adsorption performance.
34896419	6	13	theme	surface	1038:1044	arg1	area					1046:1049	the surface area	1034:1049	the surface area	1034:1049	The adsorption ability of CHKB was improved by increasing the surface area and an abundance of surface functional groups (-OH, -NH, CO, etc.).
34896419	6	14	theme	CHKB	1002:1005	arg1	ability					991:997	The adsorption ability	976:997	The adsorption ability of CHKB	976:1005	The adsorption ability of CHKB was improved by increasing the surface area and an abundance of surface functional groups (-OH, -NH, CO, etc.).
34896419	6	15	theme	surface	1071:1077	arg1	groups					1090:1095	surface functional groups	1071:1095	surface functional groups (-OH, -NH, CO, etc.)	1071:1116	The adsorption ability of CHKB was improved by increasing the surface area and an abundance of surface functional groups (-OH, -NH, CO, etc.).
34896419	1	16	theme	modified	156:163	arg1	biochar					165:171	low-cost modified biochar	147:171	low-cost modified biochar for the removal of Cd (II) from wastewater	147:214	Production of cost-efficient composite materials from low-cost modified biochar for the removal of Cd (II) from wastewater is much needed to meet the growing needs of industrial wastewater treatments.
34896419	0	17	theme	branch	77:82	arg1	biochar					84:90	kiwi branch biochar	72:90	kiwi branch biochar	72:90	Efficient removal of Cd (II) from aqueous solution by chitosan modified kiwi branch biochar.
34896419	5	18	theme	Langmuir	870:877	arg1	adsorption					887:896	a Langmuir maximum adsorption	868:896	a Langmuir maximum adsorption capacity of Cd (II) (126.58 mg g-1)	868:932	CHKB exhibited a Langmuir maximum adsorption capacity of Cd (II) (126.58 mg g-1), whereas that of KB was only 4.26 mg g-1.
34896419	7	19	from	mechanisms	1221:1230	arg1	sorption					1239:1246	the sorption	1235:1246	the sorption of Cd (II) on CHKB	1235:1265	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	19	from	mechanisms	1221:1230	arg1	CHKB					1262:1265	CHKB	1262:1265	CHKB	1262:1265	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	6	20	theme	adsorption	980:989	arg1	ability					991:997	The adsorption ability	976:997	The adsorption ability of CHKB	976:1005	The adsorption ability of CHKB was improved by increasing the surface area and an abundance of surface functional groups (-OH, -NH, CO, etc.).
34896419	3	21	theme	characterization	462:477	arg1	experiments					479:489	Batch adsorption and characterization experiments	441:489	Batch adsorption and characterization experiments	441:489	Batch adsorption and characterization experiments indicated that the modification of kiwi biochar (KB) by chitosan remarkably improved its adsorption performance.
34896419	8	22	from	wastewater	1405:1414	arg1	removal					1383:1389	the removal	1379:1389	the removal of Cd (II) in wastewater	1379:1414	Excellent adsorption performance, low cost, and environmental-friendliness made CHKB a fantastic adsorbent for the removal of Cd (II) in wastewater.
34896419	3	23	theme	kiwi	526:529	arg1	KB					540:541	KB	540:541	KB	540:541	Batch adsorption and characterization experiments indicated that the modification of kiwi biochar (KB) by chitosan remarkably improved its adsorption performance.
34896419	3	23	theme	kiwi	526:529	arg1	biochar					531:537	kiwi biochar	526:537	kiwi biochar (KB)	526:542	Batch adsorption and characterization experiments indicated that the modification of kiwi biochar (KB) by chitosan remarkably improved its adsorption performance.
34896419	0	24	theme	Efficient	0:8	arg1	removal					10:16	Efficient removal	0:16	Efficient removal of Cd (II) from aqueous solution by chitosan	0:61	Efficient removal of Cd (II) from aqueous solution by chitosan modified kiwi branch biochar.
34896419	3	25	theme	biochar	531:537	arg1	modification					510:521	the modification	506:521	the modification of kiwi biochar (KB) by chitosan	506:554	Batch adsorption and characterization experiments indicated that the modification of kiwi biochar (KB) by chitosan remarkably improved its adsorption performance.
34896419	0	26	theme	Cd	21:22	arg1	removal					10:16	Efficient removal	0:16	Efficient removal of Cd (II) from aqueous solution by chitosan	0:61	Efficient removal of Cd (II) from aqueous solution by chitosan modified kiwi branch biochar.
34896419	8	27	theme	Cd	1394:1395	arg1	removal					1383:1389	the removal	1379:1389	the removal of Cd (II) in wastewater	1379:1414	Excellent adsorption performance, low cost, and environmental-friendliness made CHKB a fantastic adsorbent for the removal of Cd (II) in wastewater.
34896419	8	28	theme	low	1302:1304	arg1	cost					1306:1309	low cost	1302:1309	low cost	1302:1309	Excellent adsorption performance, low cost, and environmental-friendliness made CHKB a fantastic adsorbent for the removal of Cd (II) in wastewater.
34896419	5	29	theme	adsorption	887:896	arg1	capacity					898:905	a Langmuir maximum adsorption capacity	868:905	a Langmuir maximum adsorption capacity of Cd (II) (126.58 mg g-1)	868:932	CHKB exhibited a Langmuir maximum adsorption capacity of Cd (II) (126.58 mg g-1), whereas that of KB was only 4.26 mg g-1.
34896419	7	30	from	sorption	1239:1246	arg1	CHKB					1262:1265	CHKB	1262:1265	CHKB	1262:1265	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	31	theme	surface	1167:1173	arg1	mechanisms					1221:1230	the main mechanisms	1212:1230	the main mechanisms in the sorption of Cd (II) on CHKB	1212:1265	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	31	theme	surface	1167:1173	arg1	exchange					1130:1137	The cation exchange	1119:1137	The cation exchange	1119:1137	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	31	theme	surface	1167:1173	arg1	interaction					1154:1164	electrostatic interaction	1140:1164	electrostatic interaction	1140:1164	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	31	theme	surface	1167:1173	arg1	complexation					1175:1186	surface complexation	1167:1186	surface complexation	1167:1186	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	31	theme	surface	1167:1173	arg1	precipitation					1193:1205	precipitation	1193:1205	precipitation	1193:1205	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	4	32	theme	Langmuir	682:689	arg1	model					691:695	a Langmuir model	680:695	a Langmuir model	680:695	The results revealed that the adsorption isotherms can be best described by a Langmuir model and that a pseudo-second-order model fits the Cd (II) adsorption kinetics well, which indicates that it is a monolayer process controlled by chemisorption.
34896419	5	33	theme	maximum	879:885	arg1	adsorption					887:896	a Langmuir maximum adsorption	868:896	a Langmuir maximum adsorption capacity of Cd (II) (126.58 mg g-1)	868:932	CHKB exhibited a Langmuir maximum adsorption capacity of Cd (II) (126.58 mg g-1), whereas that of KB was only 4.26 mg g-1.
34896419	6	34	dep	groups	1090:1095	arg1	CO					1108:1109	CO	1108:1109	CO	1108:1109	The adsorption ability of CHKB was improved by increasing the surface area and an abundance of surface functional groups (-OH, -NH, CO, etc.).
34896419	6	34	dep	groups	1090:1095	arg1	-NH					1103:1105	-NH	1103:1105	-NH	1103:1105	The adsorption ability of CHKB was improved by increasing the surface area and an abundance of surface functional groups (-OH, -NH, CO, etc.).
34896419	6	34	dep	groups	1090:1095	arg1	-OH					1098:1100	-OH	1098:1100	-OH	1098:1100	The adsorption ability of CHKB was improved by increasing the surface area and an abundance of surface functional groups (-OH, -NH, CO, etc.).
34896419	6	34	dep	groups	1090:1095	arg1	etc					1112:1114	etc	1112:1114	etc	1112:1114	The adsorption ability of CHKB was improved by increasing the surface area and an abundance of surface functional groups (-OH, -NH, CO, etc.).
34896419	2	35	theme	kiwi	320:323	arg1	CHKB					341:344	CHKB	341:344	CHKB	341:344	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	2	35	theme	kiwi	320:323	arg1	biochar					332:338	A novel chitosan-modified kiwi branch biochar	294:338	A novel chitosan-modified kiwi branch biochar (CHKB)	294:345	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	2	35	theme	kiwi	320:323	arg1	biochar					383:389	low-cost modified biochar	365:389	low-cost modified biochar for the removal of Cd (II) from aqueous solution	365:438	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	3	36	theme	adsorption	580:589	arg1	performance					591:601	its adsorption performance	576:601	its adsorption performance	576:601	Batch adsorption and characterization experiments indicated that the modification of kiwi biochar (KB) by chitosan remarkably improved its adsorption performance.
34896419	2	37	theme	modified	374:381	arg1	biochar					332:338	A novel chitosan-modified kiwi branch biochar	294:338	A novel chitosan-modified kiwi branch biochar (CHKB)	294:345	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	2	37	theme	modified	374:381	arg1	biochar					383:389	low-cost modified biochar	365:389	low-cost modified biochar for the removal of Cd (II) from aqueous solution	365:438	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	7	38	theme	electrostatic	1140:1152	arg1	mechanisms					1221:1230	the main mechanisms	1212:1230	the main mechanisms in the sorption of Cd (II) on CHKB	1212:1265	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	38	theme	electrostatic	1140:1152	arg1	exchange					1130:1137	The cation exchange	1119:1137	The cation exchange	1119:1137	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	38	theme	electrostatic	1140:1152	arg1	interaction					1154:1164	electrostatic interaction	1140:1164	electrostatic interaction	1140:1164	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	38	theme	electrostatic	1140:1152	arg1	complexation					1175:1186	surface complexation	1167:1186	surface complexation	1167:1186	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	38	theme	electrostatic	1140:1152	arg1	precipitation					1193:1205	precipitation	1193:1205	precipitation	1193:1205	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	1	39	theme	Cd	192:193	arg1	removal					181:187	the removal	177:187	the removal of Cd (II) from wastewater	177:214	Production of cost-efficient composite materials from low-cost modified biochar for the removal of Cd (II) from wastewater is much needed to meet the growing needs of industrial wastewater treatments.
34896419	4	40	theme	adsorption	751:760	arg1	kinetics					762:769	the Cd (II) adsorption kinetics	739:769	the Cd (II) adsorption kinetics	739:769	The results revealed that the adsorption isotherms can be best described by a Langmuir model and that a pseudo-second-order model fits the Cd (II) adsorption kinetics well, which indicates that it is a monolayer process controlled by chemisorption.
34896419	2	41	theme	low-cost	365:372	arg1	biochar					332:338	A novel chitosan-modified kiwi branch biochar	294:338	A novel chitosan-modified kiwi branch biochar (CHKB)	294:345	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	2	41	theme	low-cost	365:372	arg1	biochar					383:389	low-cost modified biochar	365:389	low-cost modified biochar for the removal of Cd (II) from aqueous solution	365:438	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	8	42	from	removal	1383:1389	arg1	wastewater					1405:1414	wastewater	1405:1414	wastewater	1405:1414	Excellent adsorption performance, low cost, and environmental-friendliness made CHKB a fantastic adsorbent for the removal of Cd (II) in wastewater.
34896419	6	43	theme	functional	1079:1088	arg1	groups					1090:1095	surface functional groups	1071:1095	surface functional groups (-OH, -NH, CO, etc.)	1071:1116	The adsorption ability of CHKB was improved by increasing the surface area and an abundance of surface functional groups (-OH, -NH, CO, etc.).
34896419	0	44	from	solution	42:49	arg1	removal					10:16	Efficient removal	0:16	Efficient removal of Cd (II) from aqueous solution by chitosan	0:61	Efficient removal of Cd (II) from aqueous solution by chitosan modified kiwi branch biochar.
34896419	7	45	theme	Cd	1251:1252	arg1	sorption					1239:1246	the sorption	1235:1246	the sorption of Cd (II) on CHKB	1235:1265	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	1	46	theme	industrial	260:269	arg1	treatments					282:291	industrial wastewater treatments	260:291	industrial wastewater treatments	260:291	Production of cost-efficient composite materials from low-cost modified biochar for the removal of Cd (II) from wastewater is much needed to meet the growing needs of industrial wastewater treatments.
34896419	2	47	from	solution	431:438	arg1	removal					399:405	the removal	395:405	the removal of Cd (II) from aqueous solution	395:438	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	2	48	theme	chitosan-modified	302:318	arg1	CHKB					341:344	CHKB	341:344	CHKB	341:344	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	2	48	theme	chitosan-modified	302:318	arg1	biochar					332:338	A novel chitosan-modified kiwi branch biochar	294:338	A novel chitosan-modified kiwi branch biochar (CHKB)	294:345	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	2	48	theme	chitosan-modified	302:318	arg1	biochar					383:389	low-cost modified biochar	365:389	low-cost modified biochar for the removal of Cd (II) from aqueous solution	365:438	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	2	49	theme	Cd	410:411	arg1	removal					399:405	the removal	395:405	the removal of Cd (II) from aqueous solution	395:438	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	1	50	theme	wastewater	271:280	arg1	treatments					282:291	industrial wastewater treatments	260:291	industrial wastewater treatments	260:291	Production of cost-efficient composite materials from low-cost modified biochar for the removal of Cd (II) from wastewater is much needed to meet the growing needs of industrial wastewater treatments.
34896419	1	51	from	wastewater	205:214	arg1	removal					181:187	the removal	177:187	the removal of Cd (II) from wastewater	177:214	Production of cost-efficient composite materials from low-cost modified biochar for the removal of Cd (II) from wastewater is much needed to meet the growing needs of industrial wastewater treatments.
34896419	3	52	theme	adsorption	447:456	arg1	experiments					479:489	Batch adsorption and characterization experiments	441:489	Batch adsorption and characterization experiments	441:489	Batch adsorption and characterization experiments indicated that the modification of kiwi biochar (KB) by chitosan remarkably improved its adsorption performance.
34896419	2	53	theme	novel	296:300	arg1	CHKB					341:344	CHKB	341:344	CHKB	341:344	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	2	53	theme	novel	296:300	arg1	biochar					332:338	A novel chitosan-modified kiwi branch biochar	294:338	A novel chitosan-modified kiwi branch biochar (CHKB)	294:345	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	2	53	theme	novel	296:300	arg1	biochar					383:389	low-cost modified biochar	365:389	low-cost modified biochar for the removal of Cd (II) from aqueous solution	365:438	A novel chitosan-modified kiwi branch biochar (CHKB) was fabricated as low-cost modified biochar for the removal of Cd (II) from aqueous solution.
34896419	8	54	theme	Excellent	1268:1276	arg1	performance					1289:1299	Excellent adsorption performance	1268:1299	Excellent adsorption performance	1268:1299	Excellent adsorption performance, low cost, and environmental-friendliness made CHKB a fantastic adsorbent for the removal of Cd (II) in wastewater.
34896419	4	55	theme	Cd	743:744	arg1	kinetics					762:769	the Cd (II) adsorption kinetics	739:769	the Cd (II) adsorption kinetics	739:769	The results revealed that the adsorption isotherms can be best described by a Langmuir model and that a pseudo-second-order model fits the Cd (II) adsorption kinetics well, which indicates that it is a monolayer process controlled by chemisorption.
34896419	4	56	theme	adsorption	634:643	arg1	isotherms					645:653	the adsorption isotherms	630:653	the adsorption isotherms	630:653	The results revealed that the adsorption isotherms can be best described by a Langmuir model and that a pseudo-second-order model fits the Cd (II) adsorption kinetics well, which indicates that it is a monolayer process controlled by chemisorption.
34896419	7	57	theme	cation	1123:1128	arg1	mechanisms					1221:1230	the main mechanisms	1212:1230	the main mechanisms in the sorption of Cd (II) on CHKB	1212:1265	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	57	theme	cation	1123:1128	arg1	exchange					1130:1137	The cation exchange	1119:1137	The cation exchange	1119:1137	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	57	theme	cation	1123:1128	arg1	interaction					1154:1164	electrostatic interaction	1140:1164	electrostatic interaction	1140:1164	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	57	theme	cation	1123:1128	arg1	complexation					1175:1186	surface complexation	1167:1186	surface complexation	1167:1186	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	57	theme	cation	1123:1128	arg1	precipitation					1193:1205	precipitation	1193:1205	precipitation	1193:1205	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	6	58	theme	groups	1090:1095	arg1	area					1046:1049	the surface area	1034:1049	the surface area	1034:1049	The adsorption ability of CHKB was improved by increasing the surface area and an abundance of surface functional groups (-OH, -NH, CO, etc.).
34896419	6	58	theme	groups	1090:1095	arg1	abundance					1058:1066	an abundance	1055:1066	an abundance of surface functional groups (-OH, -NH, CO, etc.)	1055:1116	The adsorption ability of CHKB was improved by increasing the surface area and an abundance of surface functional groups (-OH, -NH, CO, etc.).
34896419	1	59	theme	cost-efficient	107:120	arg1	materials					132:140	cost-efficient composite materials	107:140	cost-efficient composite materials	107:140	Production of cost-efficient composite materials from low-cost modified biochar for the removal of Cd (II) from wastewater is much needed to meet the growing needs of industrial wastewater treatments.
34896419	8	60	theme	adsorption	1278:1287	arg1	performance					1289:1299	Excellent adsorption performance	1268:1299	Excellent adsorption performance	1268:1299	Excellent adsorption performance, low cost, and environmental-friendliness made CHKB a fantastic adsorbent for the removal of Cd (II) in wastewater.
34896419	1	61	theme	composite	122:130	arg1	materials					132:140	cost-efficient composite materials	107:140	cost-efficient composite materials	107:140	Production of cost-efficient composite materials from low-cost modified biochar for the removal of Cd (II) from wastewater is much needed to meet the growing needs of industrial wastewater treatments.
34896419	0	62	theme	aqueous	34:40	arg1	solution					42:49	aqueous solution	34:49	aqueous solution	34:49	Efficient removal of Cd (II) from aqueous solution by chitosan modified kiwi branch biochar.
34896419	8	63	theme	a	1353:1353	arg1	fantastic					1355:1363	CHKB a fantastic	1348:1363	CHKB a fantastic	1348:1363	Excellent adsorption performance, low cost, and environmental-friendliness made CHKB a fantastic adsorbent for the removal of Cd (II) in wastewater.
34896419	7	64	theme	main	1216:1219	arg1	mechanisms					1221:1230	the main mechanisms	1212:1230	the main mechanisms in the sorption of Cd (II) on CHKB	1212:1265	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	64	theme	main	1216:1219	arg1	exchange					1130:1137	The cation exchange	1119:1137	The cation exchange	1119:1137	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	64	theme	main	1216:1219	arg1	interaction					1154:1164	electrostatic interaction	1140:1164	electrostatic interaction	1140:1164	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	64	theme	main	1216:1219	arg1	complexation					1175:1186	surface complexation	1167:1186	surface complexation	1167:1186	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	64	theme	main	1216:1219	arg1	precipitation					1193:1205	precipitation	1193:1205	precipitation	1193:1205	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	1	65	theme	materials	132:140	arg1	Production					93:102	Production	93:102	Production of cost-efficient composite materials from low-cost modified biochar for the removal of Cd (II) from wastewater	93:214	Production of cost-efficient composite materials from low-cost modified biochar for the removal of Cd (II) from wastewater is much needed to meet the growing needs of industrial wastewater treatments.
34896419	7	66	from	CHKB	1262:1265	arg1	mechanisms					1221:1230	the main mechanisms	1212:1230	the main mechanisms in the sorption of Cd (II) on CHKB	1212:1265	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	66	from	CHKB	1262:1265	arg1	exchange					1130:1137	The cation exchange	1119:1137	The cation exchange	1119:1137	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	66	from	CHKB	1262:1265	arg1	interaction					1154:1164	electrostatic interaction	1140:1164	electrostatic interaction	1140:1164	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	66	from	CHKB	1262:1265	arg1	complexation					1175:1186	surface complexation	1167:1186	surface complexation	1167:1186	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34896419	7	66	from	CHKB	1262:1265	arg1	precipitation					1193:1205	precipitation	1193:1205	precipitation	1193:1205	The cation exchange, electrostatic interaction, surface complexation, and precipitation were the main mechanisms in the sorption of Cd (II) on CHKB.
34961941	11	0	theme	protein	1872:1878	arg1	activities					1933:1942	the metabolic activities	1919:1942	the metabolic activities of microorganisms that end in a short shelf life	1919:1991	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	11	0	theme	protein	1872:1878	arg1	oxidation					1848:1856	the oxidation	1844:1856	the oxidation of lipids and protein	1844:1878	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	11	0	theme	protein	1872:1878	arg1	action					1885:1890	the action	1881:1890	the action of endogenous enzymes	1881:1912	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	3	1	theme	meat	909:912	arg1	samples					914:920	all meat samples	905:920	all meat samples	905:920	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	14	2	theme	chemistry	2451:2459	arg1	quality					2473:2479	the chemistry and sensory quality	2447:2479	the chemistry and sensory quality of turkey breast fillets	2447:2504	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	0	3	theme	stored	178:183	arg1	fillets					199:205	chill stored turkey breast fillets	172:205	chill stored turkey breast fillets	172:205	Protective effect of chitosan-loaded nanoemulsion containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils as coating on lipid and protein oxidation in chill stored turkey breast fillets.
34961941	8	4	theme	chitosan	1471:1478	arg1	treatments					1480:1489	sonicated chitosan treatments	1461:1489	sonicated chitosan treatments	1461:1489	Chitosan and sonicated chitosan treatments had the highest color score and lowest odor score at zero time.
34961941	11	5	theme	lipids	1861:1866	arg1	activities					1933:1942	the metabolic activities	1919:1942	the metabolic activities of microorganisms that end in a short shelf life	1919:1991	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	11	5	theme	lipids	1861:1866	arg1	oxidation					1848:1856	the oxidation	1844:1856	the oxidation of lipids and protein	1844:1878	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	11	5	theme	lipids	1861:1866	arg1	action					1885:1890	the action	1881:1890	the action of endogenous enzymes	1881:1912	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	3	6	theme	highest	942:948	arg1	limit					961:965	the highest acceptable limit	938:965	the highest acceptable limit (28-29 mg N/100 g)	938:984	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	3	6	theme	highest	942:948	arg1	N/100 g					977:983	28-29 mg N/100 g	968:983	28-29 mg N/100 g	968:983	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	5	7	dep	1.97 ±	1174:1179	arg1	0.39					1196:1199	0.39	1196:1199	0.39	1196:1199	TBARs values of the samples (mg MDA/kg) ranged from 1.97 ± 0.04 to 4.48 ± 0.39 in CNE + ZEO 1% to 2.72 ± 0.32 to 6.66 ± 0.21 in CON at zero time and day 5, respectively.
34961941	5	7	dep	1.97 ±	1174:1179	arg1	to					1186:1187	to	1186:1187	to	1186:1187	TBARs values of the samples (mg MDA/kg) ranged from 1.97 ± 0.04 to 4.48 ± 0.39 in CNE + ZEO 1% to 2.72 ± 0.32 to 6.66 ± 0.21 in CON at zero time and day 5, respectively.
34961941	0	8	theme	breast	192:197	arg1	fillets					199:205	chill stored turkey breast fillets	172:205	chill stored turkey breast fillets	172:205	Protective effect of chitosan-loaded nanoemulsion containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils as coating on lipid and protein oxidation in chill stored turkey breast fillets.
34961941	1	9	theme	protein	266:272	arg1	responses					284:292	the lipid and protein oxidation responses	252:292	responses	284:292	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	10	10	theme	PRACTICAL	1698:1706	arg1	APPLICATION					1708:1718	PRACTICAL APPLICATION	1698:1718	PRACTICAL APPLICATION: The spoilage risk of fresh products is higher than other foods.	1698:1783	PRACTICAL APPLICATION: The spoilage risk of fresh products is higher than other foods.
34961941	9	11	with	fillets	1606:1612	arg1	BEO					1627:1629	BEO	1627:1629	BEO	1627:1629	The obtained results suggested coating turkey meat fillets with ZEO and BEO as an effective strategy to delay at their chemical deterioration.
34961941	9	11	with	fillets	1606:1612	arg1	ZEO					1619:1621	ZEO	1619:1621	ZEO	1619:1621	The obtained results suggested coating turkey meat fillets with ZEO and BEO as an effective strategy to delay at their chemical deterioration.
34961941	8	12	theme	highest	1499:1505	arg1	score					1513:1517	the highest color score	1495:1517	the highest color score	1495:1517	Chitosan and sonicated chitosan treatments had the highest color score and lowest odor score at zero time.
34961941	2	13	theme	free	610:613	arg1	FFA					628:630	FFA	628:630	FFA	628:630	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	13	theme	free	610:613	arg1	acids					621:625	free fatty acids	610:625	free fatty acids (FFA)	610:631	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	3	14	theme	28-29 mg	968:975	arg1	limit					961:965	the highest acceptable limit	938:965	the highest acceptable limit (28-29 mg N/100 g)	938:984	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	3	14	theme	28-29 mg	968:975	arg1	N/100 g					977:983	28-29 mg N/100 g	968:983	28-29 mg N/100 g	968:983	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	4	15	theme	PV	1010:1011	arg1	values					1023:1028	PV and TBARs values	1010:1028	PV and TBARs values	1010:1028	In all the treatments, PV and TBARs values were increased until day 10, and afterward a decrease was observed until day 20 of storage.
34961941	10	16	theme	spoilage	1725:1732	arg1	risk					1734:1737	The spoilage risk	1721:1737	The spoilage risk of fresh products	1721:1755	PRACTICAL APPLICATION: The spoilage risk of fresh products is higher than other foods.
34961941	10	16	theme	spoilage	1725:1732	arg1	higher					1760:1765	higher	1760:1765	higher	1760:1765	PRACTICAL APPLICATION: The spoilage risk of fresh products is higher than other foods.
34961941	8	17	theme	lowest	1523:1528	arg1	score					1535:1539	lowest odor score	1523:1539	lowest odor score at zero time	1523:1552	Chitosan and sonicated chitosan treatments had the highest color score and lowest odor score at zero time.
34961941	14	18	theme	poultry	2418:2424	arg1	industry					2426:2433	poultry industry	2418:2433	poultry industry	2418:2433	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	4	19	theme	TBARs	1017:1021	arg1	values					1023:1028	PV and TBARs values	1010:1028	PV and TBARs values	1010:1028	In all the treatments, PV and TBARs values were increased until day 10, and afterward a decrease was observed until day 20 of storage.
34961941	1	20	theme	plants	413:418	arg1	oils					392:395	the essential oils	378:395	the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss	378:479	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	11	21	theme	enzymes	1906:1912	arg1	activities					1933:1942	the metabolic activities	1919:1942	the metabolic activities of microorganisms that end in a short shelf life	1919:1991	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	11	21	theme	enzymes	1906:1912	arg1	oxidation					1848:1856	the oxidation	1844:1856	the oxidation of lipids and protein	1844:1878	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	11	21	theme	enzymes	1906:1912	arg1	action					1885:1890	the action	1881:1890	the action of endogenous enzymes	1881:1912	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	2	22	theme	reactive	581:588	arg1	TBARs					602:606	TBARs	602:606	TBARs	602:606	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	22	theme	reactive	581:588	arg1	substances					590:599	thiobarbituric reactive substances	566:599	thiobarbituric reactive substances (TBARs)	566:607	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	12	23	theme	edible	2068:2073	arg1	coatings					2075:2082	edible coatings	2068:2082	edible coatings	2068:2082	The oxidation of lipids not only reduces or retards, but also inhibits by edible coatings.
34961941	2	24	theme	total	665:669	arg1	carbonyl					671:678	total carbonyl	665:678	total carbonyl	665:678	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	24	theme	total	665:669	arg1	nitrogen					527:534	total volatile basic nitrogen (TVB-N)	506:542	total volatile basic nitrogen (TVB-N)	506:542	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	10	25	theme	products	1748:1755	arg1	risk					1734:1737	The spoilage risk	1721:1737	The spoilage risk of fresh products	1721:1755	PRACTICAL APPLICATION: The spoilage risk of fresh products is higher than other foods.
34961941	10	25	theme	products	1748:1755	arg1	higher					1760:1765	higher	1760:1765	higher	1760:1765	PRACTICAL APPLICATION: The spoilage risk of fresh products is higher than other foods.
34961941	0	26	theme	protein	151:157	arg1	oxidation					159:167	protein oxidation	151:167	protein oxidation	151:167	Protective effect of chitosan-loaded nanoemulsion containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils as coating on lipid and protein oxidation in chill stored turkey breast fillets.
34961941	14	27	theme	food	2389:2392	arg1	industry					2394:2401	food industry	2389:2401	food industry	2389:2401	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	13	28	theme	foods	2227:2231	arg1	surface					2196:2202	surface	2196:2202	surface of minimally processed foods	2196:2231	Edible coatings formed from bioactive compounds would effectively provide possibility of active compounds onto surface of minimally processed foods.
34961941	2	29	theme	samples	684:690	arg1	TBARs					602:606	TBARs	602:606	TBARs	602:606	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	29	theme	samples	684:690	arg1	FFA					628:630	FFA	628:630	FFA	628:630	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	29	theme	samples	684:690	arg1	TC					661:662	TC	661:662	TC	661:662	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	29	theme	samples	684:690	arg1	nitrogen					527:534	total volatile basic nitrogen (TVB-N)	506:542	total volatile basic nitrogen (TVB-N)	506:542	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	29	theme	samples	684:690	arg1	value					554:558	peroxide value	545:558	peroxide value (PV)	545:563	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	29	theme	samples	684:690	arg1	acids					621:625	free fatty acids	610:625	free fatty acids (FFA)	610:631	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	29	theme	samples	684:690	arg1	substances					590:599	thiobarbituric reactive substances	566:599	thiobarbituric reactive substances (TBARs)	566:607	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	29	theme	samples	684:690	arg1	PV					561:562	PV	561:562	PV	561:562	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	29	theme	samples	684:690	arg1	composition					645:655	fatty acid composition	634:655	fatty acid composition	634:655	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	29	theme	samples	684:690	arg1	carbonyl					671:678	total carbonyl	665:678	total carbonyl	665:678	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	10	30	theme	other	1772:1776	arg1	foods					1778:1782	other foods	1772:1782	other foods	1772:1782	PRACTICAL APPLICATION: The spoilage risk of fresh products is higher than other foods.
34961941	1	31	theme	chitosan-contained	327:344	arg1	nanoemulsions					346:358	chitosan-contained nanoemulsions	327:358	chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss	327:479	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	7	32	theme	efficient	1367:1375	arg1	CNE					1434:1436	CNE	1434:1436	CNE	1434:1436	The most efficient treatment against chemical deterioration was found to be CNE + ZEO 1%.
34961941	7	32	theme	efficient	1367:1375	arg1	treatment					1377:1385	The most efficient treatment	1358:1385	The most efficient treatment against chemical deterioration	1358:1416	The most efficient treatment against chemical deterioration was found to be CNE + ZEO 1%.
34961941	2	33	theme	volatile	512:519	arg1	nitrogen					527:534	total volatile basic nitrogen (TVB-N)	506:542	total volatile basic nitrogen (TVB-N)	506:542	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	33	theme	volatile	512:519	arg1	carbonyl					671:678	total carbonyl	665:678	total carbonyl	665:678	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	3	34	theme	initial	808:814	arg1	value					816:820	The initial value	804:820	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples	804:920	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	3	34	theme	initial	808:814	arg1	lower					927:931	lower	927:931	lower	927:931	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	14	35	theme	Boiss	2350:2354	arg1	oils					2366:2369	Zataria multiflora Boiss and Bunium persicum Boiss essential oils	2305:2369	Zataria multiflora Boiss and Bunium persicum Boiss essential oils	2305:2369	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	4	36	theme	storage	1113:1119	arg1	day					1103:1105	day 20	1103:1108	day 20 of storage	1103:1119	In all the treatments, PV and TBARs values were increased until day 10, and afterward a decrease was observed until day 20 of storage.
34961941	13	37	theme	compounds	2181:2189	arg1	possibility					2159:2169	possibility	2159:2169	possibility of active compounds	2159:2189	Edible coatings formed from bioactive compounds would effectively provide possibility of active compounds onto surface of minimally processed foods.
34961941	3	38	theme	2.24 mg	836:842	arg1	TVB-N					829:833	the TVB-N	825:833	the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values	825:890	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	3	38	theme	2.24 mg	836:842	arg1	N/100 g					844:850	2.24 mg N/100 g	836:850	2.24 mg N/100 g	836:850	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	11	39	theme	short	1976:1980	arg1	shelf					1982:1986	a short shelf	1974:1986	a short shelf life	1974:1991	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	3	40	theme	TVB-N	829:833	arg1	value					816:820	The initial value	804:820	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples	804:920	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	3	40	theme	TVB-N	829:833	arg1	lower					927:931	lower	927:931	lower	927:931	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	13	41	theme	processed	2217:2225	arg1	foods					2227:2231	minimally processed foods	2207:2231	minimally processed foods	2207:2231	Edible coatings formed from bioactive compounds would effectively provide possibility of active compounds onto surface of minimally processed foods.
34961941	0	42	theme	Protective	0:9	arg1	effect					11:16	Protective effect	0:16	Protective effect of chitosan-loaded nanoemulsion	0:48	Protective effect of chitosan-loaded nanoemulsion containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils as coating on lipid and protein oxidation in chill stored turkey breast fillets.
34961941	1	43	theme	oxidation	274:282	arg1	responses					284:292	the lipid and protein oxidation responses	252:292	responses	284:292	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	3	44	theme	20.81 mg	861:868	arg1	values					885:890	20.81 mg N/100 g. TVB-N values	861:890	20.81 mg N/100 g. TVB-N values	861:890	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	9	45	theme	coating	1586:1592	arg1	fillets					1606:1612	coating turkey meat fillets	1586:1612	coating turkey meat fillets with ZEO and BEO	1586:1629	The obtained results suggested coating turkey meat fillets with ZEO and BEO as an effective strategy to delay at their chemical deterioration.
34961941	9	45	theme	coating	1586:1592	arg1	strategy					1647:1654	an effective strategy	1634:1654	an effective strategy to delay at their chemical deterioration	1634:1695	The obtained results suggested coating turkey meat fillets with ZEO and BEO as an effective strategy to delay at their chemical deterioration.
34961941	2	46	theme	fatty	634:638	arg1	composition					645:655	fatty acid composition	634:655	fatty acid composition	634:655	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	0	47	dep	Boiss	80:84	arg1	oils					122:125	essential oils	112:125	essential oils	112:125	Protective effect of chitosan-loaded nanoemulsion containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils as coating on lipid and protein oxidation in chill stored turkey breast fillets.
34961941	7	48	theme	ZEO	1440:1442	arg1	%					1445:1445	ZEO 1%	1440:1445	ZEO 1%	1440:1445	The most efficient treatment against chemical deterioration was found to be CNE + ZEO 1%.
34961941	9	49	theme	meat	1601:1604	arg1	fillets					1606:1612	coating turkey meat fillets	1586:1612	coating turkey meat fillets with ZEO and BEO	1586:1629	The obtained results suggested coating turkey meat fillets with ZEO and BEO as an effective strategy to delay at their chemical deterioration.
34961941	9	49	theme	meat	1601:1604	arg1	strategy					1647:1654	an effective strategy	1634:1654	an effective strategy to delay at their chemical deterioration	1634:1695	The obtained results suggested coating turkey meat fillets with ZEO and BEO as an effective strategy to delay at their chemical deterioration.
34961941	10	50	dep	APPLICATION	1708:1718	arg1	risk					1734:1737	The spoilage risk	1721:1737	The spoilage risk of fresh products	1721:1755	PRACTICAL APPLICATION: The spoilage risk of fresh products is higher than other foods.
34961941	10	50	dep	APPLICATION	1708:1718	arg1	higher					1760:1765	higher	1760:1765	higher	1760:1765	PRACTICAL APPLICATION: The spoilage risk of fresh products is higher than other foods.
34961941	0	51	theme	nanoemulsion	37:48	arg1	effect					11:16	Protective effect	0:16	Protective effect of chitosan-loaded nanoemulsion	0:48	Protective effect of chitosan-loaded nanoemulsion containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils as coating on lipid and protein oxidation in chill stored turkey breast fillets.
34961941	1	52	theme	stored	302:307	arg1	meat					316:319	cold stored turkey meat	297:319	cold stored turkey meat	297:319	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	13	53	theme	bioactive	2113:2121	arg1	compounds					2123:2131	bioactive compounds	2113:2131	bioactive compounds	2113:2131	Edible coatings formed from bioactive compounds would effectively provide possibility of active compounds onto surface of minimally processed foods.
34961941	14	54	theme	fillets	2498:2504	arg1	quality					2473:2479	the chemistry and sensory quality	2447:2479	the chemistry and sensory quality of turkey breast fillets	2447:2504	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	11	55	theme	metabolic	1923:1931	arg1	activities					1933:1942	the metabolic activities	1919:1942	the metabolic activities of microorganisms that end in a short shelf life	1919:1991	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	1	56	theme	meat	316:319	arg1	lipid					256:260	the lipid and protein oxidation responses	252:292	lipid	256:260	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	1	56	theme	meat	316:319	arg1	responses					284:292	the lipid and protein oxidation responses	252:292	responses	284:292	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	11	57	theme	endogenous	1895:1904	arg1	enzymes					1906:1912	endogenous enzymes	1895:1912	endogenous enzymes	1895:1912	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	3	58	theme	TVB-N	879:883	arg1	values					885:890	20.81 mg N/100 g. TVB-N values	861:890	20.81 mg N/100 g. TVB-N values	861:890	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	14	59	theme	turkey	2484:2489	arg1	fillets					2498:2504	turkey breast fillets	2484:2504	turkey breast fillets	2484:2504	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	11	60	from	end	1967:1969	arg1	life					1988:1991	a short shelf life	1974:1991	a short shelf life	1974:1991	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	14	61	theme	nanoemulsion	2273:2284	arg1	coating					2286:2292	application chitosan-loaded nanoemulsion coating	2245:2292	application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils	2245:2369	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	13	62	theme	Edible	2085:2090	arg1	coatings					2092:2099	Edible coatings	2085:2099	Edible coatings formed from bioactive compounds	2085:2131	Edible coatings formed from bioactive compounds would effectively provide possibility of active compounds onto surface of minimally processed foods.
34961941	5	63	from	0.21	1242:1245	arg1	CON					1250:1252	CON	1250:1252	CON	1250:1252	TBARs values of the samples (mg MDA/kg) ranged from 1.97 ± 0.04 to 4.48 ± 0.39 in CNE + ZEO 1% to 2.72 ± 0.32 to 6.66 ± 0.21 in CON at zero time and day 5, respectively.
34961941	2	64	theme	sensory	740:746	arg1	properties					748:757	sensory properties	740:757	sensory properties	740:757	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	5	65	theme	ZEO	1210:1212	arg1	%					1215:1215	ZEO 1%	1210:1215	ZEO 1%	1210:1215	TBARs values of the samples (mg MDA/kg) ranged from 1.97 ± 0.04 to 4.48 ± 0.39 in CNE + ZEO 1% to 2.72 ± 0.32 to 6.66 ± 0.21 in CON at zero time and day 5, respectively.
34961941	5	66	theme	TBARs	1122:1126	arg1	values					1128:1133	TBARs values	1122:1133	TBARs values of the samples (mg MDA/kg)	1122:1160	TBARs values of the samples (mg MDA/kg) ranged from 1.97 ± 0.04 to 4.48 ± 0.39 in CNE + ZEO 1% to 2.72 ± 0.32 to 6.66 ± 0.21 in CON at zero time and day 5, respectively.
34961941	14	67	theme	application	2245:2255	arg1	coating					2286:2292	application chitosan-loaded nanoemulsion coating	2245:2292	application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils	2245:2369	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	9	68	theme	effective	1637:1645	arg1	strategy					1647:1654	an effective strategy	1634:1654	an effective strategy to delay at their chemical deterioration	1634:1695	The obtained results suggested coating turkey meat fillets with ZEO and BEO as an effective strategy to delay at their chemical deterioration.
34961941	9	68	theme	effective	1637:1645	arg1	fillets					1606:1612	coating turkey meat fillets	1586:1612	coating turkey meat fillets with ZEO and BEO	1586:1629	The obtained results suggested coating turkey meat fillets with ZEO and BEO as an effective strategy to delay at their chemical deterioration.
34961941	2	69	theme	same	787:790	arg1	conditions					792:801	the same conditions	783:801	the same conditions	783:801	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	0	70	theme	turkey	185:190	arg1	fillets					199:205	chill stored turkey breast fillets	172:205	chill stored turkey breast fillets	172:205	Protective effect of chitosan-loaded nanoemulsion containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils as coating on lipid and protein oxidation in chill stored turkey breast fillets.
34961941	8	71	theme	sonicated	1461:1469	arg1	treatments					1480:1489	sonicated chitosan treatments	1461:1489	sonicated chitosan treatments	1461:1489	Chitosan and sonicated chitosan treatments had the highest color score and lowest odor score at zero time.
34961941	2	72	theme	fatty	615:619	arg1	FFA					628:630	FFA	628:630	FFA	628:630	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	72	theme	fatty	615:619	arg1	acids					621:625	free fatty acids	610:625	free fatty acids (FFA)	610:631	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	9	73	theme	chemical	1674:1681	arg1	deterioration					1683:1695	their chemical deterioration	1668:1695	their chemical deterioration	1668:1695	The obtained results suggested coating turkey meat fillets with ZEO and BEO as an effective strategy to delay at their chemical deterioration.
34961941	6	74	theme	slower	1322:1327	arg1	rate					1329:1332	a slower rate	1320:1332	a slower rate in the treated samples	1320:1355	FFA and TC were enhanced at a slower rate in the treated samples.
34961941	3	75	theme	acceptable	950:959	arg1	limit					961:965	the highest acceptable limit	938:965	the highest acceptable limit (28-29 mg N/100 g)	938:984	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	3	75	theme	acceptable	950:959	arg1	N/100 g					977:983	28-29 mg N/100 g	968:983	28-29 mg N/100 g	968:983	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	11	76	theme	Turkey	1785:1790	arg1	meat					1792:1795	Turkey meat	1785:1795	Turkey meat	1785:1795	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	8	77	theme	color	1507:1511	arg1	score					1513:1517	the highest color score	1495:1517	the highest color score	1495:1517	Chitosan and sonicated chitosan treatments had the highest color score and lowest odor score at zero time.
34961941	11	78	theme	biological	1815:1824	arg1	reactions					1826:1834	biological reactions	1815:1834	biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life	1815:1991	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	11	78	theme	biological	1815:1824	arg1	action					1885:1890	the action	1881:1890	the action of endogenous enzymes	1881:1912	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	11	78	theme	biological	1815:1824	arg1	oxidation					1848:1856	the oxidation	1844:1856	the oxidation of lipids and protein	1844:1878	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	11	78	theme	biological	1815:1824	arg1	activities					1933:1942	the metabolic activities	1919:1942	the metabolic activities of microorganisms that end in a short shelf life	1919:1991	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	5	79	dep	6.66 ±	1235:1240	arg1	to					1232:1233	to	1232:1233	to	1232:1233	TBARs values of the samples (mg MDA/kg) ranged from 1.97 ± 0.04 to 4.48 ± 0.39 in CNE + ZEO 1% to 2.72 ± 0.32 to 6.66 ± 0.21 in CON at zero time and day 5, respectively.
34961941	1	80	theme	present	212:218	arg1	study					220:224	The present study	208:224	The present study	208:224	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	2	81	theme	peroxide	545:552	arg1	PV					561:562	PV	561:562	PV	561:562	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	81	theme	peroxide	545:552	arg1	value					554:558	peroxide value	545:558	peroxide value (PV)	545:563	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	8	82	from	time	1549:1552	arg1	score					1513:1517	the highest color score	1495:1517	the highest color score	1495:1517	Chitosan and sonicated chitosan treatments had the highest color score and lowest odor score at zero time.
34961941	8	82	from	time	1549:1552	arg1	score					1535:1539	lowest odor score	1523:1539	lowest odor score at zero time	1523:1552	Chitosan and sonicated chitosan treatments had the highest color score and lowest odor score at zero time.
34961941	8	83	theme	odor	1530:1533	arg1	score					1535:1539	lowest odor score	1523:1539	lowest odor score at zero time	1523:1552	Chitosan and sonicated chitosan treatments had the highest color score and lowest odor score at zero time.
34961941	7	84	theme	chemical	1395:1402	arg1	deterioration					1404:1416	chemical deterioration	1395:1416	chemical deterioration	1395:1416	The most efficient treatment against chemical deterioration was found to be CNE + ZEO 1%.
34961941	2	85	theme	thiobarbituric	566:579	arg1	TBARs					602:606	TBARs	602:606	TBARs	602:606	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	85	theme	thiobarbituric	566:579	arg1	substances					590:599	thiobarbituric reactive substances	566:599	thiobarbituric reactive substances (TBARs)	566:607	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	5	86	theme	mg	1151:1152	arg1	samples					1142:1148	the samples	1138:1148	the samples (mg MDA/kg)	1138:1160	TBARs values of the samples (mg MDA/kg) ranged from 1.97 ± 0.04 to 4.48 ± 0.39 in CNE + ZEO 1% to 2.72 ± 0.32 to 6.66 ± 0.21 in CON at zero time and day 5, respectively.
34961941	5	86	theme	mg	1151:1152	arg1	MDA/kg					1154:1159	mg MDA/kg	1151:1159	mg MDA/kg	1151:1159	TBARs values of the samples (mg MDA/kg) ranged from 1.97 ± 0.04 to 4.48 ± 0.39 in CNE + ZEO 1% to 2.72 ± 0.32 to 6.66 ± 0.21 in CON at zero time and day 5, respectively.
34961941	10	87	theme	fresh	1742:1746	arg1	products					1748:1755	fresh products	1742:1755	fresh products	1742:1755	PRACTICAL APPLICATION: The spoilage risk of fresh products is higher than other foods.
34961941	0	88	theme	chill	172:176	arg1	fillets					199:205	chill stored turkey breast fillets	172:205	chill stored turkey breast fillets	172:205	Protective effect of chitosan-loaded nanoemulsion containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils as coating on lipid and protein oxidation in chill stored turkey breast fillets.
34961941	13	89	theme	active	2174:2179	arg1	compounds					2181:2189	active compounds	2174:2189	active compounds	2174:2189	Edible coatings formed from bioactive compounds would effectively provide possibility of active compounds onto surface of minimally processed foods.
34961941	2	90	theme	basic	521:525	arg1	nitrogen					527:534	total volatile basic nitrogen (TVB-N)	506:542	total volatile basic nitrogen (TVB-N)	506:542	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	90	theme	basic	521:525	arg1	carbonyl					671:678	total carbonyl	665:678	total carbonyl	665:678	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	5	91	from	0.39	1196:1199	arg1	%					1215:1215	ZEO 1%	1210:1215	ZEO 1%	1210:1215	TBARs values of the samples (mg MDA/kg) ranged from 1.97 ± 0.04 to 4.48 ± 0.39 in CNE + ZEO 1% to 2.72 ± 0.32 to 6.66 ± 0.21 in CON at zero time and day 5, respectively.
34961941	5	91	from	0.39	1196:1199	arg1	CNE					1204:1206	CNE	1204:1206	CNE	1204:1206	TBARs values of the samples (mg MDA/kg) ranged from 1.97 ± 0.04 to 4.48 ± 0.39 in CNE + ZEO 1% to 2.72 ± 0.32 to 6.66 ± 0.21 in CON at zero time and day 5, respectively.
34961941	6	92	theme	treated	1341:1347	arg1	samples					1349:1355	the treated samples	1337:1355	the treated samples	1337:1355	FFA and TC were enhanced at a slower rate in the treated samples.
34961941	14	93	theme	essential	2356:2364	arg1	oils					2366:2369	Zataria multiflora Boiss and Bunium persicum Boiss essential oils	2305:2369	Zataria multiflora Boiss and Bunium persicum Boiss essential oils	2305:2369	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	2	94	theme	total	506:510	arg1	nitrogen					527:534	total volatile basic nitrogen (TVB-N)	506:542	total volatile basic nitrogen (TVB-N)	506:542	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	94	theme	total	506:510	arg1	carbonyl					671:678	total carbonyl	665:678	total carbonyl	665:678	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	5	95	theme	samples	1142:1148	arg1	values					1128:1133	TBARs values	1122:1133	TBARs values of the samples (mg MDA/kg)	1122:1160	TBARs values of the samples (mg MDA/kg) ranged from 1.97 ± 0.04 to 4.48 ± 0.39 in CNE + ZEO 1% to 2.72 ± 0.32 to 6.66 ± 0.21 in CON at zero time and day 5, respectively.
34961941	0	96	theme	essential	112:120	arg1	oils					122:125	essential oils	112:125	essential oils	112:125	Protective effect of chitosan-loaded nanoemulsion containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils as coating on lipid and protein oxidation in chill stored turkey breast fillets.
34961941	6	97	from	rate	1329:1332	arg1	samples					1349:1355	the treated samples	1337:1355	the treated samples	1337:1355	FFA and TC were enhanced at a slower rate in the treated samples.
34961941	1	98	theme	essential	382:390	arg1	oils					392:395	the essential oils	378:395	the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss	378:479	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	9	99	theme	obtained	1559:1566	arg1	results					1568:1574	The obtained results	1555:1574	The obtained results	1555:1574	The obtained results suggested coating turkey meat fillets with ZEO and BEO as an effective strategy to delay at their chemical deterioration.
34961941	12	100	theme	lipids	2011:2016	arg1	oxidation					1998:2006	The oxidation	1994:2006	The oxidation of lipids	1994:2016	The oxidation of lipids not only reduces or retards, but also inhibits by edible coatings.
34961941	8	101	contain	had	1491:1493	arg2	score					1513:1517	the highest color score	1495:1517	the highest color score	1495:1517	Chitosan and sonicated chitosan treatments had the highest color score and lowest odor score at zero time.
34961941	8	101	contain	had	1491:1493	arg2	score					1535:1539	lowest odor score	1523:1539	lowest odor score at zero time	1523:1552	Chitosan and sonicated chitosan treatments had the highest color score and lowest odor score at zero time.
34961941	8	101	contain	had	1491:1493	arg1	Chitosan					1448:1455	Chitosan	1448:1455	Chitosan	1448:1455	Chitosan and sonicated chitosan treatments had the highest color score and lowest odor score at zero time.
34961941	8	101	contain	had	1491:1493	arg1	treatments					1480:1489	sonicated chitosan treatments	1461:1489	sonicated chitosan treatments	1461:1489	Chitosan and sonicated chitosan treatments had the highest color score and lowest odor score at zero time.
34961941	2	102	theme	acid	640:643	arg1	composition					645:655	fatty acid composition	634:655	fatty acid composition	634:655	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	1	103	theme	aromatic	404:411	arg1	plants					413:418	two aromatic plants	400:418	two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss	400:479	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	1	103	theme	aromatic	404:411	arg1	Boiss					475:479	Boiss	475:479	Boiss	475:479	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	1	103	theme	aromatic	404:411	arg1	Boiss					449:453	Boiss	449:453	Boiss	449:453	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	0	104	theme	chitosan-loaded	21:35	arg1	nanoemulsion					37:48	chitosan-loaded nanoemulsion	21:48	chitosan-loaded nanoemulsion	21:48	Protective effect of chitosan-loaded nanoemulsion containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils as coating on lipid and protein oxidation in chill stored turkey breast fillets.
34961941	3	105	theme	N/100 g.	870:877	arg1	values					885:890	20.81 mg N/100 g. TVB-N values	861:890	20.81 mg N/100 g. TVB-N values	861:890	The initial value of the TVB-N (2.24 mg N/100 g) reached 20.81 mg N/100 g. TVB-N values achieved for all meat samples were lower than the highest acceptable limit (28-29 mg N/100 g).
34961941	9	106	theme	turkey	1594:1599	arg1	fillets					1606:1612	coating turkey meat fillets	1586:1612	coating turkey meat fillets with ZEO and BEO	1586:1629	The obtained results suggested coating turkey meat fillets with ZEO and BEO as an effective strategy to delay at their chemical deterioration.
34961941	9	106	theme	turkey	1594:1599	arg1	strategy					1647:1654	an effective strategy	1634:1654	an effective strategy to delay at their chemical deterioration	1634:1695	The obtained results suggested coating turkey meat fillets with ZEO and BEO as an effective strategy to delay at their chemical deterioration.
34961941	1	107	theme	cold	297:300	arg1	meat					316:319	cold stored turkey meat	297:319	cold stored turkey meat	297:319	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	14	108	theme	Boiss	2324:2328	arg1	oils					2366:2369	Zataria multiflora Boiss and Bunium persicum Boiss essential oils	2305:2369	Zataria multiflora Boiss and Bunium persicum Boiss essential oils	2305:2369	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	11	109	theme	microorganisms	1947:1960	arg1	activities					1933:1942	the metabolic activities	1919:1942	the metabolic activities of microorganisms that end in a short shelf life	1919:1991	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	11	109	theme	microorganisms	1947:1960	arg1	oxidation					1848:1856	the oxidation	1844:1856	the oxidation of lipids and protein	1844:1878	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	11	109	theme	microorganisms	1947:1960	arg1	action					1885:1890	the action	1881:1890	the action of endogenous enzymes	1881:1912	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	11	110	theme	shelf	1982:1986	arg1	life					1988:1991	a short shelf life	1974:1991	a short shelf life	1974:1991	Turkey meat spoils because of biological reactions such as the oxidation of lipids and protein, the action of endogenous enzymes, and the metabolic activities of microorganisms that end in a short shelf life.
34961941	1	111	theme	turkey	309:314	arg1	meat					316:319	cold stored turkey meat	297:319	cold stored turkey meat	297:319	The present study was conducted to evaluate the lipid and protein oxidation responses of cold stored turkey meat using chitosan-contained nanoemulsions supplemented with the essential oils of two aromatic plants including Zataria multiflora Boiss and Bunium persicum Boiss.
34961941	5	112	dep	CNE	1204:1206	arg1	2.72 ±					1220:1225	2.72 ±	1220:1225	to 2.72 ± 0.32 to 6.66 ± 0.21 in CON at zero time and day 5	1217:1275	TBARs values of the samples (mg MDA/kg) ranged from 1.97 ± 0.04 to 4.48 ± 0.39 in CNE + ZEO 1% to 2.72 ± 0.32 to 6.66 ± 0.21 in CON at zero time and day 5, respectively.
34961941	14	113	theme	breast	2491:2496	arg1	fillets					2498:2504	turkey breast fillets	2484:2504	turkey breast fillets	2484:2504	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	2	114	theme	Chemical	482:489	arg1	TC					661:662	TC	661:662	TC	661:662	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	114	theme	Chemical	482:489	arg1	nitrogen					527:534	total volatile basic nitrogen (TVB-N)	506:542	total volatile basic nitrogen (TVB-N)	506:542	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	114	theme	Chemical	482:489	arg1	value					554:558	peroxide value	545:558	peroxide value (PV)	545:563	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	114	theme	Chemical	482:489	arg1	acids					621:625	free fatty acids	610:625	free fatty acids (FFA)	610:631	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	114	theme	Chemical	482:489	arg1	traits					491:496	Chemical traits	482:496	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples	482:690	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	114	theme	Chemical	482:489	arg1	substances					590:599	thiobarbituric reactive substances	566:599	thiobarbituric reactive substances (TBARs)	566:607	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	2	114	theme	Chemical	482:489	arg1	composition					645:655	fatty acid composition	634:655	fatty acid composition	634:655	Chemical traits such as total volatile basic nitrogen (TVB-N), peroxide value (PV), thiobarbituric reactive substances (TBARs), free fatty acids (FFA), fatty acid composition and TC (total carbonyl) of samples were carried out at 4°C. Moreover, their pH and sensory properties were also determined at the same conditions.
34961941	14	115	contain	containing	2294:2303	arg1	coating					2286:2292	application chitosan-loaded nanoemulsion coating	2245:2292	application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils	2245:2369	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	14	115	contain	containing	2294:2303	arg2	oils					2366:2369	Zataria multiflora Boiss and Bunium persicum Boiss essential oils	2305:2369	Zataria multiflora Boiss and Bunium persicum Boiss essential oils	2305:2369	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	14	116	theme	chitosan-loaded	2257:2271	arg1	coating					2286:2292	application chitosan-loaded nanoemulsion coating	2245:2292	application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils	2245:2369	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	14	117	theme	sensory	2465:2471	arg1	quality					2473:2479	the chemistry and sensory quality	2447:2479	the chemistry and sensory quality of turkey breast fillets	2447:2504	Therefore, application chitosan-loaded nanoemulsion coating containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils is recommended in food industry especially for poultry industry to increase the chemistry and sensory quality of turkey breast fillets.
34961941	0	118	from	coating	130:136	arg1	lipid					141:145	lipid	141:145	lipid	141:145	Protective effect of chitosan-loaded nanoemulsion containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils as coating on lipid and protein oxidation in chill stored turkey breast fillets.
34961941	0	118	from	coating	130:136	arg1	oxidation					159:167	protein oxidation	151:167	protein oxidation	151:167	Protective effect of chitosan-loaded nanoemulsion containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils as coating on lipid and protein oxidation in chill stored turkey breast fillets.
34961941	0	118	from	coating	130:136	arg1	fillets					199:205	chill stored turkey breast fillets	172:205	chill stored turkey breast fillets	172:205	Protective effect of chitosan-loaded nanoemulsion containing Zataria multiflora Boiss and Bunium persicum Boiss essential oils as coating on lipid and protein oxidation in chill stored turkey breast fillets.
33455363	7	0	theme	osteosarcoma-affected	1235:1255	arg1	regeneration					1262:1273	osteosarcoma-affected bone regeneration	1235:1273	osteosarcoma-affected bone regeneration	1235:1273	As such, HAP/κ-CA-MA-CAS/DOX implants are viable prospects for osteosarcoma-affected bone regeneration.
33455363	1	1	theme	implant	183:189	arg1	fabrications					151:162	the fabrications	147:162	the fabrications of an osteosarcoma implant for bone repair	147:205	Here, we focus on the fabrications of an osteosarcoma implant for bone repair via the development of a hydroxyapatite/κ-carrageenan-maleic anhydride/casein with doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate.
33455363	0	2	theme	Implant	120:126	arg1	Assessment					8:17	In Vivo Assessment	0:17	In Vivo Assessment of a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant	0:126	In Vivo Assessment of a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant.
33455363	7	3	theme	bone	1257:1260	arg1	regeneration					1262:1273	osteosarcoma-affected bone regeneration	1235:1273	osteosarcoma-affected bone regeneration	1235:1273	As such, HAP/κ-CA-MA-CAS/DOX implants are viable prospects for osteosarcoma-affected bone regeneration.
33455363	2	4	theme	Ti	416:417	arg1	plate					419:423	the Ti plate	412:423	the Ti plate	412:423	The HAP/κ-CA-MA-CAS/DOX material was coated on the Ti plate through the EPD method (electrophoretic deposition), applying direct current (DC) signals to deposit the composite on the surface of the Ti plate.
33455363	2	5	theme	Ti	562:563	arg1	plate					565:569	the Ti plate	558:569	the Ti plate	558:569	The HAP/κ-CA-MA-CAS/DOX material was coated on the Ti plate through the EPD method (electrophoretic deposition), applying direct current (DC) signals to deposit the composite on the surface of the Ti plate.
33455363	3	6	theme	bone	752:755	arg1	regeneration					757:768	bone regeneration	752:768	bone regeneration	752:768	The physicochemical and morphological possessions and biocompatibility in vitro of the prepared nanocomposite were examined to assess its prospective effectiveness for purposes of bone regeneration.
33455363	4	7	theme	osteoblast-like	855:869	arg1	cells					871:875	MG63 osteoblast-like cells	850:875	MG63 osteoblast-like cells	850:875	Excellent biocompatibility and elevated osteoconductivity were confirmed using MG63 osteoblast-like cells.
33455363	1	8	theme	composite-deposited	324:342	arg1	plate					358:362	doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate	290:362	doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate	290:362	Here, we focus on the fabrications of an osteosarcoma implant for bone repair via the development of a hydroxyapatite/κ-carrageenan-maleic anhydride/casein with doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate.
33455363	5	9	located	detected	972:979	arg2	regeneration					955:966	rapid bone regeneration	944:966	rapid bone regeneration	944:966	In vivo studies were performed at tibia sites in Wistar rats, and rapid bone regeneration was detected at four weeks in defective bone.
33455363	5	9	located	detected	972:979	arg1	weeks					989:993	four weeks	984:993	four weeks	984:993	In vivo studies were performed at tibia sites in Wistar rats, and rapid bone regeneration was detected at four weeks in defective bone.
33455363	5	9	located	detected	972:979	arg1	bone					1008:1011	defective bone	998:1011	defective bone	998:1011	In vivo studies were performed at tibia sites in Wistar rats, and rapid bone regeneration was detected at four weeks in defective bone.
33455363	4	10	theme	MG63	850:853	arg1	cells					871:875	MG63 osteoblast-like cells	850:875	MG63 osteoblast-like cells	850:875	Excellent biocompatibility and elevated osteoconductivity were confirmed using MG63 osteoblast-like cells.
33455363	3	11	theme	physicochemical	576:590	arg1	possessions					610:620	The physicochemical and morphological possessions	572:620	The physicochemical and morphological possessions	572:620	The physicochemical and morphological possessions and biocompatibility in vitro of the prepared nanocomposite were examined to assess its prospective effectiveness for purposes of bone regeneration.
33455363	1	12	theme	titanium	344:351	arg1	plate					358:362	doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate	290:362	doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate	290:362	Here, we focus on the fabrications of an osteosarcoma implant for bone repair via the development of a hydroxyapatite/κ-carrageenan-maleic anhydride/casein with doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate.
33455363	5	13	from	sites	918:922	arg1	rats					934:937	Wistar rats	927:937	Wistar rats	927:937	In vivo studies were performed at tibia sites in Wistar rats, and rapid bone regeneration was detected at four weeks in defective bone.
33455363	6	14	theme	metallic	1153:1160	arg1	implants					1162:1169	Ti metallic implants	1150:1169	Ti metallic implants	1150:1169	Overall, the studies demonstrate that the HAP/κ-CA-MA-CAS/DOX composite enhances the biocompatible and cell-stimulating biointerface of Ti metallic implants.
33455363	1	15	theme	bone	195:198	arg1	repair					200:205	bone repair	195:205	bone repair	195:205	Here, we focus on the fabrications of an osteosarcoma implant for bone repair via the development of a hydroxyapatite/κ-carrageenan-maleic anhydride/casein with doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate.
33455363	6	16	theme	HAP/κ-CA-MA-CAS/DOX	1056:1074	arg1	composite					1076:1084	the HAP/κ-CA-MA-CAS/DOX composite	1052:1084	the HAP/κ-CA-MA-CAS/DOX composite	1052:1084	Overall, the studies demonstrate that the HAP/κ-CA-MA-CAS/DOX composite enhances the biocompatible and cell-stimulating biointerface of Ti metallic implants.
33455363	5	17	theme	In	878:879	arg1	studies					886:892	In vivo studies	878:892	In vivo studies	878:892	In vivo studies were performed at tibia sites in Wistar rats, and rapid bone regeneration was detected at four weeks in defective bone.
33455363	6	18	theme	cell-stimulating	1117:1132	arg1	biointerface					1134:1145	the biocompatible and cell-stimulating biointerface	1095:1145	the biocompatible and cell-stimulating biointerface of Ti metallic implants	1095:1169	Overall, the studies demonstrate that the HAP/κ-CA-MA-CAS/DOX composite enhances the biocompatible and cell-stimulating biointerface of Ti metallic implants.
33455363	5	19	theme	rapid	944:948	arg1	regeneration					955:966	rapid bone regeneration	944:966	rapid bone regeneration	944:966	In vivo studies were performed at tibia sites in Wistar rats, and rapid bone regeneration was detected at four weeks in defective bone.
33455363	5	20	dep	In	878:879	arg1	vivo					881:884	vivo	881:884	vivo	881:884	In vivo studies were performed at tibia sites in Wistar rats, and rapid bone regeneration was detected at four weeks in defective bone.
33455363	5	21	theme	bone	950:953	arg1	regeneration					955:966	rapid bone regeneration	944:966	rapid bone regeneration	944:966	In vivo studies were performed at tibia sites in Wistar rats, and rapid bone regeneration was detected at four weeks in defective bone.
33455363	0	22	theme	In	0:1	arg1	Assessment					8:17	In Vivo Assessment	0:17	In Vivo Assessment of a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant	0:126	In Vivo Assessment of a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant.
33455363	2	23	theme	HAP/κ-CA-MA-CAS/DOX	369:387	arg1	material					389:396	The HAP/κ-CA-MA-CAS/DOX material	365:396	The HAP/κ-CA-MA-CAS/DOX material	365:396	The HAP/κ-CA-MA-CAS/DOX material was coated on the Ti plate through the EPD method (electrophoretic deposition), applying direct current (DC) signals to deposit the composite on the surface of the Ti plate.
33455363	2	24	theme	EPD	437:439	arg1	method					441:446	the EPD method	433:446	the EPD method (electrophoretic deposition)	433:475	The HAP/κ-CA-MA-CAS/DOX material was coated on the Ti plate through the EPD method (electrophoretic deposition), applying direct current (DC) signals to deposit the composite on the surface of the Ti plate.
33455363	2	24	theme	EPD	437:439	arg1	deposition					465:474	electrophoretic deposition	449:474	electrophoretic deposition	449:474	The HAP/κ-CA-MA-CAS/DOX material was coated on the Ti plate through the EPD method (electrophoretic deposition), applying direct current (DC) signals to deposit the composite on the surface of the Ti plate.
33455363	5	25	theme	tibia	912:916	arg1	sites					918:922	tibia sites	912:922	tibia sites in Wistar rats	912:937	In vivo studies were performed at tibia sites in Wistar rats, and rapid bone regeneration was detected at four weeks in defective bone.
33455363	1	26	theme	Ti	354:355	arg1	plate					358:362	doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate	290:362	doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate	290:362	Here, we focus on the fabrications of an osteosarcoma implant for bone repair via the development of a hydroxyapatite/κ-carrageenan-maleic anhydride/casein with doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate.
33455363	6	27	theme	implants	1162:1169	arg1	biointerface					1134:1145	the biocompatible and cell-stimulating biointerface	1095:1145	the biocompatible and cell-stimulating biointerface of Ti metallic implants	1095:1169	Overall, the studies demonstrate that the HAP/κ-CA-MA-CAS/DOX composite enhances the biocompatible and cell-stimulating biointerface of Ti metallic implants.
33455363	2	28	theme	direct	487:492	arg1	DC					503:504	DC	503:504	DC	503:504	The HAP/κ-CA-MA-CAS/DOX material was coated on the Ti plate through the EPD method (electrophoretic deposition), applying direct current (DC) signals to deposit the composite on the surface of the Ti plate.
33455363	2	28	theme	direct	487:492	arg1	current					494:500	direct current	487:500	direct current (DC)	487:505	The HAP/κ-CA-MA-CAS/DOX material was coated on the Ti plate through the EPD method (electrophoretic deposition), applying direct current (DC) signals to deposit the composite on the surface of the Ti plate.
33455363	2	29	from	composite	530:538	arg1	surface					547:553	the surface	543:553	the surface of the Ti plate	543:569	The HAP/κ-CA-MA-CAS/DOX material was coated on the Ti plate through the EPD method (electrophoretic deposition), applying direct current (DC) signals to deposit the composite on the surface of the Ti plate.
33455363	3	30	theme	morphological	596:608	arg1	possessions					610:620	The physicochemical and morphological possessions	572:620	The physicochemical and morphological possessions	572:620	The physicochemical and morphological possessions and biocompatibility in vitro of the prepared nanocomposite were examined to assess its prospective effectiveness for purposes of bone regeneration.
33455363	5	31	theme	Wistar	927:932	arg1	rats					934:937	Wistar rats	927:937	Wistar rats	927:937	In vivo studies were performed at tibia sites in Wistar rats, and rapid bone regeneration was detected at four weeks in defective bone.
33455363	0	32	theme	Hydroxyapatite/κ-Carrageenan-Maleic	24:58	arg1	Implant					120:126	a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant	22:126	a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant	22:126	In Vivo Assessment of a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant.
33455363	6	33	theme	Ti	1150:1151	arg1	implants					1162:1169	Ti metallic implants	1150:1169	Ti metallic implants	1150:1169	Overall, the studies demonstrate that the HAP/κ-CA-MA-CAS/DOX composite enhances the biocompatible and cell-stimulating biointerface of Ti metallic implants.
33455363	2	34	theme	electrophoretic	449:463	arg1	method					441:446	the EPD method	433:446	the EPD method (electrophoretic deposition)	433:475	The HAP/κ-CA-MA-CAS/DOX material was coated on the Ti plate through the EPD method (electrophoretic deposition), applying direct current (DC) signals to deposit the composite on the surface of the Ti plate.
33455363	2	34	theme	electrophoretic	449:463	arg1	deposition					465:474	electrophoretic deposition	449:474	electrophoretic deposition	449:474	The HAP/κ-CA-MA-CAS/DOX material was coated on the Ti plate through the EPD method (electrophoretic deposition), applying direct current (DC) signals to deposit the composite on the surface of the Ti plate.
33455363	2	35	theme	plate	565:569	arg1	surface					547:553	the surface	543:553	the surface of the Ti plate	543:569	The HAP/κ-CA-MA-CAS/DOX material was coated on the Ti plate through the EPD method (electrophoretic deposition), applying direct current (DC) signals to deposit the composite on the surface of the Ti plate.
33455363	1	36	theme	hydroxyapatite/κ-carrageenan-maleic	232:266	arg1	anhydride/casein					268:283	a hydroxyapatite/κ-carrageenan-maleic anhydride/casein	230:283	a hydroxyapatite/κ-carrageenan-maleic anhydride/casein with doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate	230:362	Here, we focus on the fabrications of an osteosarcoma implant for bone repair via the development of a hydroxyapatite/κ-carrageenan-maleic anhydride/casein with doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate.
33455363	0	37	theme	Composite-Coated	89:104	arg1	Implant					120:126	a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant	22:126	a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant	22:126	In Vivo Assessment of a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant.
33455363	7	38	theme	HAP/κ-CA-MA-CAS/DOX	1181:1199	arg1	implants					1201:1208	HAP/κ-CA-MA-CAS/DOX implants	1181:1208	HAP/κ-CA-MA-CAS/DOX implants	1181:1208	As such, HAP/κ-CA-MA-CAS/DOX implants are viable prospects for osteosarcoma-affected bone regeneration.
33455363	7	38	theme	HAP/κ-CA-MA-CAS/DOX	1181:1199	arg1	prospects					1221:1229	viable prospects	1214:1229	viable prospects for osteosarcoma-affected bone regeneration	1214:1273	As such, HAP/κ-CA-MA-CAS/DOX implants are viable prospects for osteosarcoma-affected bone regeneration.
33455363	0	39	theme	Anhydride-Casein/Doxorubicin	60:87	arg1	Implant					120:126	a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant	22:126	a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant	22:126	In Vivo Assessment of a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant.
33455363	7	40	theme	viable	1214:1219	arg1	implants					1201:1208	HAP/κ-CA-MA-CAS/DOX implants	1181:1208	HAP/κ-CA-MA-CAS/DOX implants	1181:1208	As such, HAP/κ-CA-MA-CAS/DOX implants are viable prospects for osteosarcoma-affected bone regeneration.
33455363	7	40	theme	viable	1214:1219	arg1	prospects					1221:1229	viable prospects	1214:1229	viable prospects for osteosarcoma-affected bone regeneration	1214:1273	As such, HAP/κ-CA-MA-CAS/DOX implants are viable prospects for osteosarcoma-affected bone regeneration.
33455363	4	41	theme	Excellent	771:779	arg1	biocompatibility					781:796	Excellent biocompatibility	771:796	Excellent biocompatibility	771:796	Excellent biocompatibility and elevated osteoconductivity were confirmed using MG63 osteoblast-like cells.
33455363	3	42	theme	prepared	659:666	arg1	nanocomposite					668:680	the prepared nanocomposite	655:680	the prepared nanocomposite	655:680	The physicochemical and morphological possessions and biocompatibility in vitro of the prepared nanocomposite were examined to assess its prospective effectiveness for purposes of bone regeneration.
33455363	3	43	theme	nanocomposite	668:680	arg1	biocompatibility					626:641	biocompatibility	626:641	biocompatibility in vitro of the prepared nanocomposite	626:680	The physicochemical and morphological possessions and biocompatibility in vitro of the prepared nanocomposite were examined to assess its prospective effectiveness for purposes of bone regeneration.
33455363	3	43	theme	nanocomposite	668:680	arg1	possessions					610:620	The physicochemical and morphological possessions	572:620	The physicochemical and morphological possessions	572:620	The physicochemical and morphological possessions and biocompatibility in vitro of the prepared nanocomposite were examined to assess its prospective effectiveness for purposes of bone regeneration.
33455363	4	44	theme	elevated	802:809	arg1	osteoconductivity					811:827	elevated osteoconductivity	802:827	elevated osteoconductivity	802:827	Excellent biocompatibility and elevated osteoconductivity were confirmed using MG63 osteoblast-like cells.
33455363	1	45	theme	anhydride/casein	268:283	arg1	development					215:225	the development	211:225	the development of a hydroxyapatite/κ-carrageenan-maleic anhydride/casein with doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate	211:362	Here, we focus on the fabrications of an osteosarcoma implant for bone repair via the development of a hydroxyapatite/κ-carrageenan-maleic anhydride/casein with doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate.
33455363	3	46	theme	prospective	710:720	arg1	effectiveness					722:734	its prospective effectiveness	706:734	its prospective effectiveness for purposes of bone regeneration	706:768	The physicochemical and morphological possessions and biocompatibility in vitro of the prepared nanocomposite were examined to assess its prospective effectiveness for purposes of bone regeneration.
33455363	5	47	theme	defective	998:1006	arg1	bone					1008:1011	defective bone	998:1011	defective bone	998:1011	In vivo studies were performed at tibia sites in Wistar rats, and rapid bone regeneration was detected at four weeks in defective bone.
33455363	0	48	theme	Bone	115:118	arg1	Implant					120:126	a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant	22:126	a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant	22:126	In Vivo Assessment of a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant.
33455363	0	49	theme	Titanium	106:113	arg1	Implant					120:126	a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant	22:126	a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant	22:126	In Vivo Assessment of a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant.
33455363	3	50	theme	regeneration	757:768	arg1	purposes					740:747	purposes	740:747	purposes of bone regeneration	740:768	The physicochemical and morphological possessions and biocompatibility in vitro of the prepared nanocomposite were examined to assess its prospective effectiveness for purposes of bone regeneration.
33455363	0	51	dep	In	0:1	arg1	Vivo					3:6	Vivo	3:6	Vivo	3:6	In Vivo Assessment of a Hydroxyapatite/κ-Carrageenan-Maleic Anhydride-Casein/Doxorubicin Composite-Coated Titanium Bone Implant.
33455363	1	52	with	anhydride/casein	268:283	arg1	plate					358:362	doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate	290:362	doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate	290:362	Here, we focus on the fabrications of an osteosarcoma implant for bone repair via the development of a hydroxyapatite/κ-carrageenan-maleic anhydride/casein with doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate.
33455363	1	53	theme	osteosarcoma	170:181	arg1	implant					183:189	an osteosarcoma implant	167:189	an osteosarcoma implant for bone repair	167:205	Here, we focus on the fabrications of an osteosarcoma implant for bone repair via the development of a hydroxyapatite/κ-carrageenan-maleic anhydride/casein with doxorubicin (HAP/κ-CA-MA-CAS/DOX) composite-deposited titanium (Ti) plate.
33455363	6	54	theme	biocompatible	1099:1111	arg1	biointerface					1134:1145	the biocompatible and cell-stimulating biointerface	1095:1145	the biocompatible and cell-stimulating biointerface of Ti metallic implants	1095:1169	Overall, the studies demonstrate that the HAP/κ-CA-MA-CAS/DOX composite enhances the biocompatible and cell-stimulating biointerface of Ti metallic implants.
32440871	3	0	from	concentration	582:594	arg1	effects					523:529	the effects	519:529	the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal	519:651	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	6	1	theme	6.0	1048:1050	arg1	pH					1042:1043	pH	1042:1043	pH of 6.0	1042:1050	An optimized removal efficiency of 98.50% for Microcystis aeruginosa was reached at pH of 6.0.
32440871	5	2	with	HABs	912:915	arg1	dosage					950:955	an appropriate coal fly ash dosage	922:955	an appropriate coal fly ash dosage	922:955	However, the lower or higher ratios (0.1:4, 0.1:8, 0.1:16) result in microalgae reaching a zero-point charge too late or early, which failed to effectively remove HABs with an appropriate coal fly ash dosage.
32440871	2	3	theme	buoyant-bead	236:247	arg1	method					265:270	a novel buoyant-bead flotation (BBF) method	228:270	a novel buoyant-bead flotation (BBF) method using chitosan-coated fly ash cenospheres (CFACs)	228:320	In this study, a novel buoyant-bead flotation (BBF) method using chitosan-coated fly ash cenospheres (CFACs) was developed to remove HABs in freshwater.
32440871	1	4	theme	problem	157:163	arg1	worldwide					165:173	a growing problem worldwide	147:173	a growing problem worldwide	147:173	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	1	4	theme	problem	157:163	arg1	blooms					129:134	Harmful algal blooms	115:134	Harmful algal blooms (HABs)	115:141	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	5	5	theme	lower	762:766	arg1	ratios					778:783	the lower or higher ratios	758:783	the lower or higher ratios (0.1:4, 0.1:8, 0.1:16)	758:806	However, the lower or higher ratios (0.1:4, 0.1:8, 0.1:16) result in microalgae reaching a zero-point charge too late or early, which failed to effectively remove HABs with an appropriate coal fly ash dosage.
32440871	10	6	theme	algal	1489:1493	arg1	species					1495:1501	all three algal species	1479:1501	all three algal species	1479:1501	Meanwhile, at the optimized pH and concentration, the removal efficiency of all three algal species exceeded 90.00% in 5 min.
32440871	3	7	theme	ratios	551:556	arg1	effects					523:529	the effects	519:529	the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal	519:651	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	5	8	theme	higher	771:776	arg1	ratios					778:783	the lower or higher ratios	758:783	the lower or higher ratios (0.1:4, 0.1:8, 0.1:16)	758:806	However, the lower or higher ratios (0.1:4, 0.1:8, 0.1:16) result in microalgae reaching a zero-point charge too late or early, which failed to effectively remove HABs with an appropriate coal fly ash dosage.
32440871	5	9	theme	appropriate	925:935	arg1	dosage					950:955	an appropriate coal fly ash dosage	922:955	an appropriate coal fly ash dosage	922:955	However, the lower or higher ratios (0.1:4, 0.1:8, 0.1:16) result in microalgae reaching a zero-point charge too late or early, which failed to effectively remove HABs with an appropriate coal fly ash dosage.
32440871	3	10	theme	chitosan/fly	534:545	arg1	ratios					551:556	chitosan/fly ash ratios	534:556	chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values	534:625	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	1	11	theme	algal	123:127	arg1	blooms					129:134	Harmful algal blooms	115:134	Harmful algal blooms (HABs)	115:141	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	1	11	theme	algal	123:127	arg1	worldwide					165:173	a growing problem worldwide	147:173	a growing problem worldwide	147:173	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	1	11	theme	algal	123:127	arg1	HABs					137:140	HABs	137:140	HABs	137:140	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	4	12	theme	optimized	658:666	arg1	ratio					668:672	The optimized ratio	654:672	The optimized ratio of CFACs	654:681	The optimized ratio of CFACs is 0.1:12, and the optimized CFAC concentration is 0.3-0.7 g L-1.
32440871	4	12	theme	optimized	658:666	arg1	0.1:12					686:691	0.1:12	686:691	0.1:12	686:691	The optimized ratio of CFACs is 0.1:12, and the optimized CFAC concentration is 0.3-0.7 g L-1.
32440871	5	13	theme	fly	942:944	arg1	dosage					950:955	an appropriate coal fly ash dosage	922:955	an appropriate coal fly ash dosage	922:955	However, the lower or higher ratios (0.1:4, 0.1:8, 0.1:16) result in microalgae reaching a zero-point charge too late or early, which failed to effectively remove HABs with an appropriate coal fly ash dosage.
32440871	3	14	from	effects	523:529	arg1	removal					645:651	the microalgae removal	630:651	the microalgae removal	630:651	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	3	14	from	effects	523:529	arg1	values					620:625	pH values	617:625	pH values	617:625	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	3	14	from	effects	523:529	arg1	composite					566:574	CFAC composite	561:574	CFAC composite	561:574	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	3	14	from	effects	523:529	arg1	concentration					582:594	CFAC concentration	577:594	CFAC concentration	577:594	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	3	14	from	effects	523:529	arg1	time					607:610	flotation time	597:610	flotation time	597:610	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	7	15	theme	vulgaris	1119:1126	arg1	%					1137:1137	99.37%	1132:1137	99.37%	1132:1137	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris was 99.37% and 91.63%, respectively, at pH of 8.0.
32440871	7	15	theme	vulgaris	1119:1126	arg1	efficiency					1067:1076	The optimized efficiency	1053:1076	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris	1053:1126	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris was 99.37% and 91.63%, respectively, at pH of 8.0.
32440871	3	16	theme	CFAC	561:564	arg1	composite					566:574	CFAC composite	561:574	CFAC composite	561:574	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	8	17	theme	neutral	1182:1188	arg1	conditions					1193:1202	neutral pH conditions	1182:1202	neutral pH conditions	1182:1202	At neutral pH conditions, the surface charge of microalgae cells and CFACs are different, promoting aggregate formation.
32440871	11	18	theme	optimized	1620:1628	arg1	conditions					1642:1651	the optimized operational conditions	1616:1651	the optimized operational conditions	1616:1651	The study highlights an efficient and inexpensive method for removing HABs and obtains the optimized operational conditions.
32440871	0	19	from	Removal	0:6	arg1	freshwater					35:44	freshwater	35:44	freshwater	35:44	Removal of harmful algal blooms in freshwater by buoyant-bead flotation using chitosan-coated fly ash cenospheres.
32440871	7	20	theme	quadricauda	1093:1103	arg1	%					1137:1137	99.37%	1132:1137	99.37%	1132:1137	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris was 99.37% and 91.63%, respectively, at pH of 8.0.
32440871	7	20	theme	quadricauda	1093:1103	arg1	efficiency					1067:1076	The optimized efficiency	1053:1076	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris	1053:1126	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris was 99.37% and 91.63%, respectively, at pH of 8.0.
32440871	0	21	theme	fly	94:96	arg1	cenospheres					102:112	chitosan-coated fly ash cenospheres	78:112	chitosan-coated fly ash cenospheres	78:112	Removal of harmful algal blooms in freshwater by buoyant-bead flotation using chitosan-coated fly ash cenospheres.
32440871	0	22	from	freshwater	35:44	arg1	Removal					0:6	Removal	0:6	Removal of harmful algal blooms in freshwater by buoyant-bead flotation	0:70	Removal of harmful algal blooms in freshwater by buoyant-bead flotation using chitosan-coated fly ash cenospheres.
32440871	3	23	theme	removal	384:390	arg1	efficiency					392:401	a high removal efficiency	377:401	a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa)	377:492	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	9	24	used	used	1316:1319	arg2	CFACs					1305:1309	CFACs	1305:1309	CFACs	1305:1309	When CFACs were used to remove microalgae, aggregate size significantly influenced removal efficiency.
32440871	0	25	from	blooms	25:30	arg1	freshwater					35:44	freshwater	35:44	freshwater	35:44	Removal of harmful algal blooms in freshwater by buoyant-bead flotation using chitosan-coated fly ash cenospheres.
32440871	10	26	theme	species	1495:1501	arg1	efficiency					1465:1474	the removal efficiency	1453:1474	the removal efficiency of all three algal species	1453:1501	Meanwhile, at the optimized pH and concentration, the removal efficiency of all three algal species exceeded 90.00% in 5 min.
32440871	5	27	theme	zero-point	840:849	arg1	charge					851:856	a zero-point charge	838:856	a zero-point charge too late or early	838:874	However, the lower or higher ratios (0.1:4, 0.1:8, 0.1:16) result in microalgae reaching a zero-point charge too late or early, which failed to effectively remove HABs with an appropriate coal fly ash dosage.
32440871	8	28	theme	microalgae	1227:1236	arg1	cells					1238:1242	microalgae cells	1227:1242	microalgae cells	1227:1242	At neutral pH conditions, the surface charge of microalgae cells and CFACs are different, promoting aggregate formation.
32440871	3	29	theme	algae	414:418	arg1	efficiency					392:401	a high removal efficiency	377:401	a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa)	377:492	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	0	30	theme	harmful	11:17	arg1	blooms					25:30	harmful algal blooms	11:30	harmful algal blooms in freshwater	11:44	Removal of harmful algal blooms in freshwater by buoyant-bead flotation using chitosan-coated fly ash cenospheres.
32440871	3	31	theme	flotation	597:605	arg1	time					607:610	flotation time	597:610	flotation time	597:610	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	3	32	from	ratios	551:556	arg1	values					620:625	pH values	617:625	pH values	617:625	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	3	32	from	ratios	551:556	arg1	composite					566:574	CFAC composite	561:574	CFAC composite	561:574	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	3	32	from	ratios	551:556	arg1	concentration					582:594	CFAC concentration	577:594	CFAC concentration	577:594	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	3	32	from	ratios	551:556	arg1	time					607:610	flotation time	597:610	flotation time	597:610	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	0	33	theme	blooms	25:30	arg1	Removal					0:6	Removal	0:6	Removal of harmful algal blooms in freshwater by buoyant-bead flotation	0:70	Removal of harmful algal blooms in freshwater by buoyant-bead flotation using chitosan-coated fly ash cenospheres.
32440871	0	34	theme	buoyant-bead	49:60	arg1	flotation					62:70	buoyant-bead flotation	49:70	buoyant-bead flotation	49:70	Removal of harmful algal blooms in freshwater by buoyant-bead flotation using chitosan-coated fly ash cenospheres.
32440871	5	35	dep	ratios	778:783	arg1	0.1:16					800:805	0.1:16	800:805	0.1:16	800:805	However, the lower or higher ratios (0.1:4, 0.1:8, 0.1:16) result in microalgae reaching a zero-point charge too late or early, which failed to effectively remove HABs with an appropriate coal fly ash dosage.
32440871	5	35	dep	ratios	778:783	arg1	0.1:8					793:797	0.1:8	793:797	0.1:8	793:797	However, the lower or higher ratios (0.1:4, 0.1:8, 0.1:16) result in microalgae reaching a zero-point charge too late or early, which failed to effectively remove HABs with an appropriate coal fly ash dosage.
32440871	5	35	dep	ratios	778:783	arg1	0.1:4					786:790	0.1:4	786:790	0.1:4	786:790	However, the lower or higher ratios (0.1:4, 0.1:8, 0.1:16) result in microalgae reaching a zero-point charge too late or early, which failed to effectively remove HABs with an appropriate coal fly ash dosage.
32440871	7	36	from	pH	1168:1169	arg1	%					1137:1137	99.37%	1132:1137	99.37%	1132:1137	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris was 99.37% and 91.63%, respectively, at pH of 8.0.
32440871	7	36	from	pH	1168:1169	arg1	%					1148:1148	91.63%	1143:1148	91.63%	1143:1148	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris was 99.37% and 91.63%, respectively, at pH of 8.0.
32440871	7	36	from	pH	1168:1169	arg1	efficiency					1067:1076	The optimized efficiency	1053:1076	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris	1053:1126	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris was 99.37% and 91.63%, respectively, at pH of 8.0.
32440871	3	37	theme	pH	617:618	arg1	values					620:625	pH values	617:625	pH values	617:625	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	4	38	theme	CFAC	712:715	arg1	concentration					717:729	the optimized CFAC concentration	698:729	the optimized CFAC concentration	698:729	The optimized ratio of CFACs is 0.1:12, and the optimized CFAC concentration is 0.3-0.7 g L-1.
32440871	4	38	theme	CFAC	712:715	arg1	0.3-0.7 g L-1					734:746	0.3-0.7 g L-1	734:746	0.3-0.7 g L-1	734:746	The optimized ratio of CFACs is 0.1:12, and the optimized CFAC concentration is 0.3-0.7 g L-1.
32440871	2	39	theme	ash	298:300	arg1	cenospheres					302:312	chitosan-coated fly ash cenospheres	278:312	chitosan-coated fly ash cenospheres (CFACs)	278:320	In this study, a novel buoyant-bead flotation (BBF) method using chitosan-coated fly ash cenospheres (CFACs) was developed to remove HABs in freshwater.
32440871	2	39	theme	ash	298:300	arg1	CFACs					315:319	CFACs	315:319	CFACs	315:319	In this study, a novel buoyant-bead flotation (BBF) method using chitosan-coated fly ash cenospheres (CFACs) was developed to remove HABs in freshwater.
32440871	1	40	theme	health	205:210	arg1	worldwide					165:173	a growing problem worldwide	147:173	a growing problem worldwide	147:173	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	1	40	theme	health	205:210	arg1	blooms					129:134	Harmful algal blooms	115:134	Harmful algal blooms (HABs)	115:141	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	6	41	theme	%	998:998	arg1	efficiency					979:988	An optimized removal efficiency	958:988	An optimized removal efficiency of 98.50% for Microcystis aeruginosa	958:1025	An optimized removal efficiency of 98.50% for Microcystis aeruginosa was reached at pH of 6.0.
32440871	3	42	from	time	607:610	arg1	effects					523:529	the effects	519:529	the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal	519:651	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	8	43	theme	aggregate	1279:1287	arg1	formation					1289:1297	aggregate formation	1279:1297	aggregate formation	1279:1297	At neutral pH conditions, the surface charge of microalgae cells and CFACs are different, promoting aggregate formation.
32440871	11	44	theme	removing	1590:1597	arg1	HABs					1599:1602	removing HABs	1590:1602	removing HABs	1590:1602	The study highlights an efficient and inexpensive method for removing HABs and obtains the optimized operational conditions.
32440871	3	45	theme	microalgae	634:643	arg1	removal					645:651	the microalgae removal	630:651	the microalgae removal	630:651	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	6	46	theme	removal	971:977	arg1	efficiency					979:988	An optimized removal efficiency	958:988	An optimized removal efficiency of 98.50% for Microcystis aeruginosa	958:1025	An optimized removal efficiency of 98.50% for Microcystis aeruginosa was reached at pH of 6.0.
32440871	2	47	theme	BBF	260:262	arg1	method					265:270	a novel buoyant-bead flotation (BBF) method	228:270	a novel buoyant-bead flotation (BBF) method using chitosan-coated fly ash cenospheres (CFACs)	228:320	In this study, a novel buoyant-bead flotation (BBF) method using chitosan-coated fly ash cenospheres (CFACs) was developed to remove HABs in freshwater.
32440871	10	48	theme	optimized	1421:1429	arg1	pH					1431:1432	the optimized pH	1417:1432	the optimized pH	1417:1432	Meanwhile, at the optimized pH and concentration, the removal efficiency of all three algal species exceeded 90.00% in 5 min.
32440871	2	49	theme	flotation	249:257	arg1	method					265:270	a novel buoyant-bead flotation (BBF) method	228:270	a novel buoyant-bead flotation (BBF) method using chitosan-coated fly ash cenospheres (CFACs)	228:320	In this study, a novel buoyant-bead flotation (BBF) method using chitosan-coated fly ash cenospheres (CFACs) was developed to remove HABs in freshwater.
32440871	1	50	theme	growing	149:155	arg1	worldwide					165:173	a growing problem worldwide	147:173	a growing problem worldwide	147:173	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	1	50	theme	growing	149:155	arg1	blooms					129:134	Harmful algal blooms	115:134	Harmful algal blooms (HABs)	115:141	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	10	51	theme	removal	1457:1463	arg1	efficiency					1465:1474	the removal efficiency	1453:1474	the removal efficiency of all three algal species	1453:1501	Meanwhile, at the optimized pH and concentration, the removal efficiency of all three algal species exceeded 90.00% in 5 min.
32440871	2	52	theme	chitosan-coated	278:292	arg1	ash					298:300	chitosan-coated fly ash	278:300	chitosan-coated fly ash cenospheres (CFACs)	278:320	In this study, a novel buoyant-bead flotation (BBF) method using chitosan-coated fly ash cenospheres (CFACs) was developed to remove HABs in freshwater.
32440871	3	53	from	values	620:625	arg1	effects					523:529	the effects	519:529	the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal	519:651	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	3	54	theme	ash	547:549	arg1	ratios					551:556	chitosan/fly ash ratios	534:556	chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values	534:625	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	1	55	theme	Harmful	115:121	arg1	blooms					129:134	Harmful algal blooms	115:134	Harmful algal blooms (HABs)	115:141	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	1	55	theme	Harmful	115:121	arg1	worldwide					165:173	a growing problem worldwide	147:173	a growing problem worldwide	147:173	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	1	55	theme	Harmful	115:121	arg1	HABs					137:140	HABs	137:140	HABs	137:140	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	5	56	theme	coal	937:940	arg1	dosage					950:955	an appropriate coal fly ash dosage	922:955	an appropriate coal fly ash dosage	922:955	However, the lower or higher ratios (0.1:4, 0.1:8, 0.1:16) result in microalgae reaching a zero-point charge too late or early, which failed to effectively remove HABs with an appropriate coal fly ash dosage.
32440871	2	57	theme	novel	230:234	arg1	method					265:270	a novel buoyant-bead flotation (BBF) method	228:270	a novel buoyant-bead flotation (BBF) method using chitosan-coated fly ash cenospheres (CFACs)	228:320	In this study, a novel buoyant-bead flotation (BBF) method using chitosan-coated fly ash cenospheres (CFACs) was developed to remove HABs in freshwater.
32440871	9	58	theme	aggregate	1343:1351	arg1	size					1353:1356	aggregate size	1343:1356	aggregate size	1343:1356	When CFACs were used to remove microalgae, aggregate size significantly influenced removal efficiency.
32440871	7	59	theme	Chlorella	1109:1117	arg1	vulgaris					1119:1126	Chlorella vulgaris	1109:1126	Chlorella vulgaris	1109:1126	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris was 99.37% and 91.63%, respectively, at pH of 8.0.
32440871	5	60	theme	ash	946:948	arg1	dosage					950:955	an appropriate coal fly ash dosage	922:955	an appropriate coal fly ash dosage	922:955	However, the lower or higher ratios (0.1:4, 0.1:8, 0.1:16) result in microalgae reaching a zero-point charge too late or early, which failed to effectively remove HABs with an appropriate coal fly ash dosage.
32440871	7	61	theme	Scenedesmus	1081:1091	arg1	quadricauda					1093:1103	Scenedesmus quadricauda	1081:1103	Scenedesmus quadricauda	1081:1103	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris was 99.37% and 91.63%, respectively, at pH of 8.0.
32440871	0	62	theme	chitosan-coated	78:92	arg1	cenospheres					102:112	chitosan-coated fly ash cenospheres	78:112	chitosan-coated fly ash cenospheres	78:112	Removal of harmful algal blooms in freshwater by buoyant-bead flotation using chitosan-coated fly ash cenospheres.
32440871	9	63	theme	removal	1383:1389	arg1	efficiency					1391:1400	removal efficiency	1383:1400	removal efficiency	1383:1400	When CFACs were used to remove microalgae, aggregate size significantly influenced removal efficiency.
32440871	11	64	theme	operational	1630:1640	arg1	conditions					1642:1651	the optimized operational conditions	1616:1651	the optimized operational conditions	1616:1651	The study highlights an efficient and inexpensive method for removing HABs and obtains the optimized operational conditions.
32440871	0	65	theme	ash	98:100	arg1	cenospheres					102:112	chitosan-coated fly ash cenospheres	78:112	chitosan-coated fly ash cenospheres	78:112	Removal of harmful algal blooms in freshwater by buoyant-bead flotation using chitosan-coated fly ash cenospheres.
32440871	5	66	theme	late	862:865	arg1	charge					851:856	a zero-point charge	838:856	a zero-point charge too late or early	838:874	However, the lower or higher ratios (0.1:4, 0.1:8, 0.1:16) result in microalgae reaching a zero-point charge too late or early, which failed to effectively remove HABs with an appropriate coal fly ash dosage.
32440871	8	67	theme	pH	1190:1191	arg1	conditions					1193:1202	neutral pH conditions	1182:1202	neutral pH conditions	1182:1202	At neutral pH conditions, the surface charge of microalgae cells and CFACs are different, promoting aggregate formation.
32440871	7	68	theme	optimized	1057:1065	arg1	%					1137:1137	99.37%	1132:1137	99.37%	1132:1137	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris was 99.37% and 91.63%, respectively, at pH of 8.0.
32440871	7	68	theme	optimized	1057:1065	arg1	efficiency					1067:1076	The optimized efficiency	1053:1076	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris	1053:1126	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris was 99.37% and 91.63%, respectively, at pH of 8.0.
32440871	1	69	theme	human	185:189	arg1	worldwide					165:173	a growing problem worldwide	147:173	a growing problem worldwide	147:173	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	1	69	theme	human	185:189	arg1	blooms					129:134	Harmful algal blooms	115:134	Harmful algal blooms (HABs)	115:141	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	5	70	theme	early	870:874	arg1	charge					851:856	a zero-point charge	838:856	a zero-point charge too late or early	838:874	However, the lower or higher ratios (0.1:4, 0.1:8, 0.1:16) result in microalgae reaching a zero-point charge too late or early, which failed to effectively remove HABs with an appropriate coal fly ash dosage.
32440871	6	71	theme	optimized	961:969	arg1	efficiency					979:988	An optimized removal efficiency	958:988	An optimized removal efficiency of 98.50% for Microcystis aeruginosa	958:1025	An optimized removal efficiency of 98.50% for Microcystis aeruginosa was reached at pH of 6.0.
32440871	3	72	from	composite	566:574	arg1	effects					523:529	the effects	519:529	the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal	519:651	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	7	73	theme	8.0	1174:1176	arg1	pH					1168:1169	pH	1168:1169	pH of 8.0	1168:1176	The optimized efficiency of Scenedesmus quadricauda and Chlorella vulgaris was 99.37% and 91.63%, respectively, at pH of 8.0.
32440871	8	74	theme	surface	1209:1215	arg1	charge					1217:1222	the surface charge	1205:1222	the surface charge of microalgae cells and CFACs	1205:1252	At neutral pH conditions, the surface charge of microalgae cells and CFACs are different, promoting aggregate formation.
32440871	8	74	theme	surface	1209:1215	arg1	different					1258:1266	different	1258:1266	different	1258:1266	At neutral pH conditions, the surface charge of microalgae cells and CFACs are different, promoting aggregate formation.
32440871	3	75	theme	high	379:382	arg1	efficiency					392:401	a high removal efficiency	377:401	a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa)	377:492	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	0	76	theme	algal	19:23	arg1	blooms					25:30	harmful algal blooms	11:30	harmful algal blooms in freshwater	11:44	Removal of harmful algal blooms in freshwater by buoyant-bead flotation using chitosan-coated fly ash cenospheres.
32440871	4	77	theme	CFACs	677:681	arg1	ratio					668:672	The optimized ratio	654:672	The optimized ratio of CFACs	654:681	The optimized ratio of CFACs is 0.1:12, and the optimized CFAC concentration is 0.3-0.7 g L-1.
32440871	4	77	theme	CFACs	677:681	arg1	0.1:12					686:691	0.1:12	686:691	0.1:12	686:691	The optimized ratio of CFACs is 0.1:12, and the optimized CFAC concentration is 0.3-0.7 g L-1.
32440871	3	78	theme	CFAC	577:580	arg1	concentration					582:594	CFAC concentration	577:594	CFAC concentration	577:594	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	8	79	theme	cells	1238:1242	arg1	charge					1217:1222	the surface charge	1205:1222	the surface charge of microalgae cells and CFACs	1205:1252	At neutral pH conditions, the surface charge of microalgae cells and CFACs are different, promoting aggregate formation.
32440871	8	79	theme	cells	1238:1242	arg1	different					1258:1266	different	1258:1266	different	1258:1266	At neutral pH conditions, the surface charge of microalgae cells and CFACs are different, promoting aggregate formation.
32440871	3	80	theme	harmful	406:412	arg1	algae					414:418	harmful algae	406:418	harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa)	406:492	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	11	81	theme	inexpensive	1567:1577	arg1	method					1579:1584	an efficient and inexpensive method	1550:1584	an efficient and inexpensive method for removing HABs	1550:1602	The study highlights an efficient and inexpensive method for removing HABs and obtains the optimized operational conditions.
32440871	8	82	theme	CFACs	1248:1252	arg1	charge					1217:1222	the surface charge	1205:1222	the surface charge of microalgae cells and CFACs	1205:1252	At neutral pH conditions, the surface charge of microalgae cells and CFACs are different, promoting aggregate formation.
32440871	8	82	theme	CFACs	1248:1252	arg1	different					1258:1266	different	1258:1266	different	1258:1266	At neutral pH conditions, the surface charge of microalgae cells and CFACs are different, promoting aggregate formation.
32440871	3	83	theme	Scenedesmus	441:451	arg1	quadricauda					453:463	Scenedesmus quadricauda	441:463	Scenedesmus quadricauda	441:463	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	2	84	from	HABs	346:349	arg1	freshwater					354:363	freshwater	354:363	freshwater	354:363	In this study, a novel buoyant-bead flotation (BBF) method using chitosan-coated fly ash cenospheres (CFACs) was developed to remove HABs in freshwater.
32440871	11	85	theme	efficient	1553:1561	arg1	method					1579:1584	an efficient and inexpensive method	1550:1584	an efficient and inexpensive method for removing HABs	1550:1602	The study highlights an efficient and inexpensive method for removing HABs and obtains the optimized operational conditions.
32440871	4	86	theme	optimized	702:710	arg1	concentration					717:729	the optimized CFAC concentration	698:729	the optimized CFAC concentration	698:729	The optimized ratio of CFACs is 0.1:12, and the optimized CFAC concentration is 0.3-0.7 g L-1.
32440871	4	86	theme	optimized	702:710	arg1	0.3-0.7 g L-1					734:746	0.3-0.7 g L-1	734:746	0.3-0.7 g L-1	734:746	The optimized ratio of CFACs is 0.1:12, and the optimized CFAC concentration is 0.3-0.7 g L-1.
32440871	2	87	theme	fly	294:296	arg1	ash					298:300	chitosan-coated fly ash	278:300	chitosan-coated fly ash cenospheres (CFACs)	278:320	In this study, a novel buoyant-bead flotation (BBF) method using chitosan-coated fly ash cenospheres (CFACs) was developed to remove HABs in freshwater.
32440871	8	88	from	conditions	1193:1202	arg1	charge					1217:1222	the surface charge	1205:1222	the surface charge of microalgae cells and CFACs	1205:1252	At neutral pH conditions, the surface charge of microalgae cells and CFACs are different, promoting aggregate formation.
32440871	8	88	from	conditions	1193:1202	arg1	different					1258:1266	different	1258:1266	different	1258:1266	At neutral pH conditions, the surface charge of microalgae cells and CFACs are different, promoting aggregate formation.
32440871	1	89	theme	ecosystem	195:203	arg1	health					205:210	ecosystem health	195:210	ecosystem health	195:210	Harmful algal blooms (HABs) are a growing problem worldwide, damaging human and ecosystem health.
32440871	3	90	dep	algae	414:418	arg1	aeruginosa					482:491	Microcystis aeruginosa	470:491	Microcystis aeruginosa	470:491	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	3	90	dep	algae	414:418	arg1	vulgaris					431:438	Chlorella vulgaris	421:438	Chlorella vulgaris	421:438	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
32440871	3	90	dep	algae	414:418	arg1	quadricauda					453:463	Scenedesmus quadricauda	441:463	Scenedesmus quadricauda	441:463	To achieve a high removal efficiency of harmful algae (Chlorella vulgaris, Scenedesmus quadricauda, and Microcystis aeruginosa), this study investigated the effects of chitosan/fly ash ratios in CFAC composite, CFAC concentration, flotation time, and pH values on the microalgae removal.
33149234	4	0	theme	communities	660:670	arg1	compositions					629:640	altered taxonomic compositions	611:640	altered taxonomic compositions of gut microbiota communities	611:670	We observed altered taxonomic compositions of gut microbiota communities upon SIV infection and at different time points of ART.
33149234	2	1	theme	long-term	352:360	arg1	ART					386:388	ART	386:388	ART	386:388	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	2	1	theme	long-term	352:360	arg1	therapy					377:383	antiretroviral therapy	362:383	short or long-term antiretroviral therapy (ART)	343:389	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	6	2	theme	differential	972:983	arg1	abundance					999:1007	differential gut bacterial abundance	972:1007	differential gut bacterial abundance	972:1007	Animals undergoing ART for various lengths of time were observed to have differential gut bacterial abundance across different time points.
33149234	0	3	theme	SIV	68:70	arg1	infection					72:80	SIV infection	68:80	SIV infection	68:80	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.
33149234	7	4	theme	SIV	1107:1109	arg1	infection					1111:1119	SIV infection	1107:1119	SIV infection	1107:1119	In addition, increased blood lipopolysaccharide (LPS) levels during SIV infection were reduced to near normal upon ART, indicating that microbial translocation and immune activation can be improved during therapy.
33149234	1	5	theme	microbial	151:159	arg1	translocation					161:173	microbial translocation	151:173	microbial translocation	151:173	Gut dysbiosis and microbial translocation are associated with chronic systemic immune activation and inflammation in HIV-1 infection.
33149234	8	6	theme	microbiome	1353:1362	arg1	increase					1312:1319	transient increase	1302:1319	transient increase of certain pathogenic bacterial microbiome	1302:1362	In conclusion, while short ART may be related to transient increase of certain pathogenic bacterial microbiome, ART may promote microbiome diversity compromised by SIV infection, improve the gut microbiota towards the healthy compositions and alleviate immune activation.
33149234	0	7	from	Alterations	0:10	arg1	therapy					124:130	short- or long-term antiretroviral therapy	89:130	short- or long-term antiretroviral therapy	89:130	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.
33149234	0	7	from	Alterations	0:10	arg1	macaques					54:61	rhesus macaques	47:61	rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy	47:130	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.
33149234	8	8	theme	microbiome	1381:1390	arg1	diversity					1392:1400	microbiome diversity	1381:1400	microbiome diversity compromised by SIV infection	1381:1429	In conclusion, while short ART may be related to transient increase of certain pathogenic bacterial microbiome, ART may promote microbiome diversity compromised by SIV infection, improve the gut microbiota towards the healthy compositions and alleviate immune activation.
33149234	2	9	theme	restoration	290:300	arg1	extent					280:285	the extent	276:285	the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART)	276:389	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	2	9	theme	restoration	290:300	arg1	unclear					394:400	unclear	394:400	unclear	394:400	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	6	10	theme	time	1026:1029	arg1	points					1031:1036	different time points	1016:1036	different time points	1016:1036	Animals undergoing ART for various lengths of time were observed to have differential gut bacterial abundance across different time points.
33149234	6	11	theme	time	945:948	arg1	lengths					934:940	various lengths	926:940	various lengths of time	926:948	Animals undergoing ART for various lengths of time were observed to have differential gut bacterial abundance across different time points.
33149234	8	12	theme	transient	1302:1310	arg1	increase					1312:1319	transient increase	1302:1319	transient increase of certain pathogenic bacterial microbiome	1302:1362	In conclusion, while short ART may be related to transient increase of certain pathogenic bacterial microbiome, ART may promote microbiome diversity compromised by SIV infection, improve the gut microbiota towards the healthy compositions and alleviate immune activation.
33149234	4	13	theme	SIV	677:679	arg1	infection					681:689	SIV infection	677:689	SIV infection	677:689	We observed altered taxonomic compositions of gut microbiota communities upon SIV infection and at different time points of ART.
33149234	8	14	theme	short	1274:1278	arg1	ART					1280:1282	short ART	1274:1282	short ART	1274:1282	In conclusion, while short ART may be related to transient increase of certain pathogenic bacterial microbiome, ART may promote microbiome diversity compromised by SIV infection, improve the gut microbiota towards the healthy compositions and alleviate immune activation.
33149234	5	15	theme	healthy	882:888	arg1	control					890:896	the healthy control	878:896	the healthy control	878:896	SIV-infected animals showed decreased diversity of gut microbiome composition, while the ART group appeared to recover towards the diversity level of the healthy control.
33149234	5	16	theme	ART	817:819	arg1	group					821:825	the ART group	813:825	the ART group	813:825	SIV-infected animals showed decreased diversity of gut microbiome composition, while the ART group appeared to recover towards the diversity level of the healthy control.
33149234	0	17	with	macaques	54:61	arg1	infection					72:80	SIV infection	68:80	SIV infection	68:80	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.
33149234	3	18	theme	SIV	494:496	arg1	infection					498:506	SIV infection	494:506	SIV infection	494:506	To understand the impact of ART on the gut microbiota, we used the rhesus macaque model of SIV infection to characterize and compare the gut microbial community upon SIV infection and during ART.
33149234	0	19	theme	short-	89:94	arg1	therapy					124:130	short- or long-term antiretroviral therapy	89:130	short- or long-term antiretroviral therapy	89:130	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.
33149234	5	20	theme	decreased	756:764	arg1	diversity					766:774	decreased diversity	756:774	decreased diversity of gut microbiome composition	756:804	SIV-infected animals showed decreased diversity of gut microbiome composition, while the ART group appeared to recover towards the diversity level of the healthy control.
33149234	7	21	theme	increased	1052:1060	arg1	levels					1093:1098	increased blood lipopolysaccharide (LPS) levels	1052:1098	increased blood lipopolysaccharide (LPS) levels during SIV infection	1052:1119	In addition, increased blood lipopolysaccharide (LPS) levels during SIV infection were reduced to near normal upon ART, indicating that microbial translocation and immune activation can be improved during therapy.
33149234	3	22	theme	infection	498:506	arg1	model					485:489	the rhesus macaque model	466:489	the rhesus macaque model of SIV infection	466:506	To understand the impact of ART on the gut microbiota, we used the rhesus macaque model of SIV infection to characterize and compare the gut microbial community upon SIV infection and during ART.
33149234	3	23	theme	ART	431:433	arg1	impact					421:426	the impact	417:426	the impact of ART on the gut microbiota	417:455	To understand the impact of ART on the gut microbiota, we used the rhesus macaque model of SIV infection to characterize and compare the gut microbial community upon SIV infection and during ART.
33149234	5	24	theme	microbiome	783:792	arg1	composition					794:804	gut microbiome composition	779:804	gut microbiome composition	779:804	SIV-infected animals showed decreased diversity of gut microbiome composition, while the ART group appeared to recover towards the diversity level of the healthy control.
33149234	7	25	theme	blood	1062:1066	arg1	LPS					1088:1090	LPS	1088:1090	LPS	1088:1090	In addition, increased blood lipopolysaccharide (LPS) levels during SIV infection were reduced to near normal upon ART, indicating that microbial translocation and immune activation can be improved during therapy.
33149234	7	25	theme	blood	1062:1066	arg1	lipopolysaccharide					1068:1085	blood lipopolysaccharide	1062:1085	increased blood lipopolysaccharide (LPS) levels during SIV infection	1052:1119	In addition, increased blood lipopolysaccharide (LPS) levels during SIV infection were reduced to near normal upon ART, indicating that microbial translocation and immune activation can be improved during therapy.
33149234	8	26	theme	bacterial	1343:1351	arg1	microbiome					1353:1362	certain pathogenic bacterial microbiome	1324:1362	certain pathogenic bacterial microbiome	1324:1362	In conclusion, while short ART may be related to transient increase of certain pathogenic bacterial microbiome, ART may promote microbiome diversity compromised by SIV infection, improve the gut microbiota towards the healthy compositions and alleviate immune activation.
33149234	8	27	theme	immune	1506:1511	arg1	activation					1513:1522	immune activation	1506:1522	immune activation	1506:1522	In conclusion, while short ART may be related to transient increase of certain pathogenic bacterial microbiome, ART may promote microbiome diversity compromised by SIV infection, improve the gut microbiota towards the healthy compositions and alleviate immune activation.
33149234	4	28	theme	gut	645:647	arg1	communities					660:670	gut microbiota communities	645:670	gut microbiota communities	645:670	We observed altered taxonomic compositions of gut microbiota communities upon SIV infection and at different time points of ART.
33149234	5	29	theme	composition	794:804	arg1	diversity					766:774	decreased diversity	756:774	decreased diversity of gut microbiome composition	756:804	SIV-infected animals showed decreased diversity of gut microbiome composition, while the ART group appeared to recover towards the diversity level of the healthy control.
33149234	7	30	theme	lipopolysaccharide	1068:1085	arg1	levels					1093:1098	increased blood lipopolysaccharide (LPS) levels	1052:1098	increased blood lipopolysaccharide (LPS) levels during SIV infection	1052:1119	In addition, increased blood lipopolysaccharide (LPS) levels during SIV infection were reduced to near normal upon ART, indicating that microbial translocation and immune activation can be improved during therapy.
33149234	2	31	theme	microbiota	309:318	arg1	restoration					290:300	restoration	290:300	restoration of gut microbiota	290:318	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	8	32	theme	certain	1324:1330	arg1	microbiome					1353:1362	certain pathogenic bacterial microbiome	1324:1362	certain pathogenic bacterial microbiome	1324:1362	In conclusion, while short ART may be related to transient increase of certain pathogenic bacterial microbiome, ART may promote microbiome diversity compromised by SIV infection, improve the gut microbiota towards the healthy compositions and alleviate immune activation.
33149234	0	33	theme	gut	19:21	arg1	microbiota					33:42	the gut bacterial microbiota	15:42	the gut bacterial microbiota	15:42	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.
33149234	4	34	theme	time	708:711	arg1	points					713:718	different time points	698:718	different time points of ART	698:725	We observed altered taxonomic compositions of gut microbiota communities upon SIV infection and at different time points of ART.
33149234	0	35	theme	antiretroviral	109:122	arg1	therapy					124:130	short- or long-term antiretroviral therapy	89:130	short- or long-term antiretroviral therapy	89:130	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.
33149234	2	36	theme	gut	305:307	arg1	microbiota					309:318	gut microbiota	305:318	gut microbiota	305:318	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	1	37	theme	chronic	195:201	arg1	activation					219:228	chronic systemic immune activation	195:228	chronic systemic immune activation	195:228	Gut dysbiosis and microbial translocation are associated with chronic systemic immune activation and inflammation in HIV-1 infection.
33149234	3	38	theme	gut	540:542	arg1	community					554:562	the gut microbial community	536:562	the gut microbial community	536:562	To understand the impact of ART on the gut microbiota, we used the rhesus macaque model of SIV infection to characterize and compare the gut microbial community upon SIV infection and during ART.
33149234	0	39	theme	long-term	99:107	arg1	therapy					124:130	short- or long-term antiretroviral therapy	89:130	short- or long-term antiretroviral therapy	89:130	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.
33149234	2	40	with	patients	329:336	arg1	ART					386:388	ART	386:388	ART	386:388	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	2	40	with	patients	329:336	arg1	therapy					377:383	antiretroviral therapy	362:383	short or long-term antiretroviral therapy (ART)	343:389	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	3	41	theme	macaque	477:483	arg1	model					485:489	the rhesus macaque model	466:489	the rhesus macaque model of SIV infection	466:506	To understand the impact of ART on the gut microbiota, we used the rhesus macaque model of SIV infection to characterize and compare the gut microbial community upon SIV infection and during ART.
33149234	1	42	theme	systemic	203:210	arg1	activation					219:228	chronic systemic immune activation	195:228	chronic systemic immune activation	195:228	Gut dysbiosis and microbial translocation are associated with chronic systemic immune activation and inflammation in HIV-1 infection.
33149234	0	43	theme	microbiota	33:42	arg1	Alterations					0:10	Alterations	0:10	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.	0:131	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.
33149234	5	44	theme	control	890:896	arg1	level					869:873	the diversity level	855:873	the diversity level of the healthy control	855:896	SIV-infected animals showed decreased diversity of gut microbiome composition, while the ART group appeared to recover towards the diversity level of the healthy control.
33149234	4	45	theme	altered	611:617	arg1	compositions					629:640	altered taxonomic compositions	611:640	altered taxonomic compositions of gut microbiota communities	611:670	We observed altered taxonomic compositions of gut microbiota communities upon SIV infection and at different time points of ART.
33149234	1	46	theme	immune	212:217	arg1	activation					219:228	chronic systemic immune activation	195:228	chronic systemic immune activation	195:228	Gut dysbiosis and microbial translocation are associated with chronic systemic immune activation and inflammation in HIV-1 infection.
33149234	0	47	theme	bacterial	23:31	arg1	microbiota					33:42	the gut bacterial microbiota	15:42	the gut bacterial microbiota	15:42	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.
33149234	6	48	theme	various	926:932	arg1	lengths					934:940	various lengths	926:940	various lengths of time	926:948	Animals undergoing ART for various lengths of time were observed to have differential gut bacterial abundance across different time points.
33149234	3	49	theme	SIV	569:571	arg1	infection					573:581	SIV infection	569:581	SIV infection	569:581	To understand the impact of ART on the gut microbiota, we used the rhesus macaque model of SIV infection to characterize and compare the gut microbial community upon SIV infection and during ART.
33149234	6	50	theme	different	1016:1024	arg1	points					1031:1036	different time points	1016:1036	different time points	1016:1036	Animals undergoing ART for various lengths of time were observed to have differential gut bacterial abundance across different time points.
33149234	0	51	theme	rhesus	47:52	arg1	macaques					54:61	rhesus macaques	47:61	rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy	47:130	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.
33149234	5	52	theme	diversity	859:867	arg1	level					869:873	the diversity level	855:873	the diversity level of the healthy control	855:896	SIV-infected animals showed decreased diversity of gut microbiome composition, while the ART group appeared to recover towards the diversity level of the healthy control.
33149234	0	53	from	macaques	54:61	arg1	therapy					124:130	short- or long-term antiretroviral therapy	89:130	short- or long-term antiretroviral therapy	89:130	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.
33149234	3	54	theme	microbial	544:552	arg1	community					554:562	the gut microbial community	536:562	the gut microbial community	536:562	To understand the impact of ART on the gut microbiota, we used the rhesus macaque model of SIV infection to characterize and compare the gut microbial community upon SIV infection and during ART.
33149234	1	55	from	activation	219:228	arg1	infection					256:264	HIV-1 infection	250:264	HIV-1 infection	250:264	Gut dysbiosis and microbial translocation are associated with chronic systemic immune activation and inflammation in HIV-1 infection.
33149234	2	56	theme	short	343:347	arg1	ART					386:388	ART	386:388	ART	386:388	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	2	56	theme	short	343:347	arg1	therapy					377:383	antiretroviral therapy	362:383	short or long-term antiretroviral therapy (ART)	343:389	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	5	57	theme	gut	779:781	arg1	composition					794:804	gut microbiome composition	779:804	gut microbiome composition	779:804	SIV-infected animals showed decreased diversity of gut microbiome composition, while the ART group appeared to recover towards the diversity level of the healthy control.
33149234	3	58	used	used	461:464	arg2	we					458:459	we	458:459	we	458:459	To understand the impact of ART on the gut microbiota, we used the rhesus macaque model of SIV infection to characterize and compare the gut microbial community upon SIV infection and during ART.
33149234	7	59	theme	microbial	1175:1183	arg1	translocation					1185:1197	microbial translocation	1175:1197	microbial translocation	1175:1197	In addition, increased blood lipopolysaccharide (LPS) levels during SIV infection were reduced to near normal upon ART, indicating that microbial translocation and immune activation can be improved during therapy.
33149234	4	60	theme	different	698:706	arg1	points					713:718	different time points	698:718	different time points of ART	698:725	We observed altered taxonomic compositions of gut microbiota communities upon SIV infection and at different time points of ART.
33149234	2	61	from	extent	280:285	arg1	patients					329:336	HIV-1 patients	323:336	HIV-1 patients with short or long-term antiretroviral therapy (ART)	323:389	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	8	62	theme	gut	1444:1446	arg1	microbiota					1448:1457	the gut microbiota	1440:1457	the gut microbiota towards the healthy compositions	1440:1490	In conclusion, while short ART may be related to transient increase of certain pathogenic bacterial microbiome, ART may promote microbiome diversity compromised by SIV infection, improve the gut microbiota towards the healthy compositions and alleviate immune activation.
33149234	8	63	theme	pathogenic	1332:1341	arg1	microbiome					1353:1362	certain pathogenic bacterial microbiome	1324:1362	certain pathogenic bacterial microbiome	1324:1362	In conclusion, while short ART may be related to transient increase of certain pathogenic bacterial microbiome, ART may promote microbiome diversity compromised by SIV infection, improve the gut microbiota towards the healthy compositions and alleviate immune activation.
33149234	4	64	theme	microbiota	649:658	arg1	communities					660:670	gut microbiota communities	645:670	gut microbiota communities	645:670	We observed altered taxonomic compositions of gut microbiota communities upon SIV infection and at different time points of ART.
33149234	3	65	from	impact	421:426	arg1	microbiota					446:455	the gut microbiota	438:455	the gut microbiota	438:455	To understand the impact of ART on the gut microbiota, we used the rhesus macaque model of SIV infection to characterize and compare the gut microbial community upon SIV infection and during ART.
33149234	4	66	theme	ART	723:725	arg1	points					713:718	different time points	698:718	different time points of ART	698:725	We observed altered taxonomic compositions of gut microbiota communities upon SIV infection and at different time points of ART.
33149234	1	67	from	inflammation	234:245	arg1	infection					256:264	HIV-1 infection	250:264	HIV-1 infection	250:264	Gut dysbiosis and microbial translocation are associated with chronic systemic immune activation and inflammation in HIV-1 infection.
33149234	8	68	theme	healthy	1471:1477	arg1	compositions					1479:1490	the healthy compositions	1467:1490	the healthy compositions	1467:1490	In conclusion, while short ART may be related to transient increase of certain pathogenic bacterial microbiome, ART may promote microbiome diversity compromised by SIV infection, improve the gut microbiota towards the healthy compositions and alleviate immune activation.
33149234	2	69	theme	HIV-1	323:327	arg1	patients					329:336	HIV-1 patients	323:336	HIV-1 patients with short or long-term antiretroviral therapy (ART)	323:389	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	0	70	from	therapy	124:130	arg1	Alterations					0:10	Alterations	0:10	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.	0:131	Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.
33149234	7	71	theme	immune	1203:1208	arg1	activation					1210:1219	immune activation	1203:1219	immune activation	1203:1219	In addition, increased blood lipopolysaccharide (LPS) levels during SIV infection were reduced to near normal upon ART, indicating that microbial translocation and immune activation can be improved during therapy.
33149234	6	72	contain	have	967:970	arg2	abundance					999:1007	differential gut bacterial abundance	972:1007	differential gut bacterial abundance	972:1007	Animals undergoing ART for various lengths of time were observed to have differential gut bacterial abundance across different time points.
33149234	6	72	contain	have	967:970	arg1	Animals					899:905	Animals	899:905	Animals undergoing ART for various lengths of time	899:948	Animals undergoing ART for various lengths of time were observed to have differential gut bacterial abundance across different time points.
33149234	8	73	theme	SIV	1417:1419	arg1	infection					1421:1429	SIV infection	1417:1429	SIV infection	1417:1429	In conclusion, while short ART may be related to transient increase of certain pathogenic bacterial microbiome, ART may promote microbiome diversity compromised by SIV infection, improve the gut microbiota towards the healthy compositions and alleviate immune activation.
33149234	3	74	theme	gut	442:444	arg1	microbiota					446:455	the gut microbiota	438:455	the gut microbiota	438:455	To understand the impact of ART on the gut microbiota, we used the rhesus macaque model of SIV infection to characterize and compare the gut microbial community upon SIV infection and during ART.
33149234	1	75	theme	Gut	133:135	arg1	dysbiosis					137:145	Gut dysbiosis	133:145	Gut dysbiosis	133:145	Gut dysbiosis and microbial translocation are associated with chronic systemic immune activation and inflammation in HIV-1 infection.
33149234	4	76	theme	taxonomic	619:627	arg1	compositions					629:640	altered taxonomic compositions	611:640	altered taxonomic compositions of gut microbiota communities	611:670	We observed altered taxonomic compositions of gut microbiota communities upon SIV infection and at different time points of ART.
33149234	6	77	theme	bacterial	989:997	arg1	abundance					999:1007	differential gut bacterial abundance	972:1007	differential gut bacterial abundance	972:1007	Animals undergoing ART for various lengths of time were observed to have differential gut bacterial abundance across different time points.
33149234	5	78	theme	SIV-infected	728:739	arg1	animals					741:747	SIV-infected animals	728:747	SIV-infected animals	728:747	SIV-infected animals showed decreased diversity of gut microbiome composition, while the ART group appeared to recover towards the diversity level of the healthy control.
33149234	6	79	theme	gut	985:987	arg1	abundance					999:1007	differential gut bacterial abundance	972:1007	differential gut bacterial abundance	972:1007	Animals undergoing ART for various lengths of time were observed to have differential gut bacterial abundance across different time points.
33149234	2	80	theme	antiretroviral	362:375	arg1	ART					386:388	ART	386:388	ART	386:388	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	2	80	theme	antiretroviral	362:375	arg1	therapy					377:383	antiretroviral therapy	362:383	short or long-term antiretroviral therapy (ART)	343:389	However, the extent of restoration of gut microbiota in HIV-1 patients with short or long-term antiretroviral therapy (ART) is unclear.
33149234	1	81	theme	HIV-1	250:254	arg1	infection					256:264	HIV-1 infection	250:264	HIV-1 infection	250:264	Gut dysbiosis and microbial translocation are associated with chronic systemic immune activation and inflammation in HIV-1 infection.
33635635	6	0	with	morphology	1102:1111	arg1	contacts					1134:1141	close cell-cell contacts	1118:1141	close cell-cell contacts	1118:1141	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	3	1	theme	Culture-expanded	437:452	arg1	VFECs					454:458	Culture-expanded VFECs	437:458	Culture-expanded VFECs	437:458	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	1	2	theme	vocal	216:220	arg1	health					227:232	vocal fold health	216:232	vocal fold health	216:232	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	9	3	theme	native	1646:1651	arg1	tissue					1653:1658	native tissue	1646:1658	native tissue morphologically	1646:1674	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	7	4	theme	AG73	1405:1408	arg1	signals					1418:1424	both RGDSP and AG73 peptide signals	1390:1424	signals	1418:1424	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers requires the presence of both RGDSP and AG73 peptide signals.
33635635	6	5	theme	stress	1239:1244	arg1	fibers					1246:1251	extensive intracellular stress fibers	1215:1251	extensive intracellular stress fibers	1215:1251	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	3	6	theme	marker	496:501	arg1	cytokeratin					503:513	the suprabasal epithelial marker cytokeratin 13	470:516	the suprabasal epithelial marker cytokeratin 13	470:516	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	6	7	theme	softer	1161:1166	arg1	matrices					1168:1175	softer matrices	1161:1175	softer matrices (G' = 41 Pa)	1161:1188	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	6	7	theme	softer	1161:1166	arg1	Pa					1186:1187	G' = 41 Pa	1178:1187	G' = 41 Pa	1178:1187	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	4	8	theme	engineered	619:628	arg1	model					630:634	the engineered model	615:634	the engineered model	615:634	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	6	9	theme	extensive	1215:1223	arg1	fibers					1246:1251	extensive intracellular stress fibers	1215:1251	extensive intracellular stress fibers	1215:1251	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	3	10	theme	suprabasal	474:483	arg1	cytokeratin					503:513	the suprabasal epithelial marker cytokeratin 13	470:516	the suprabasal epithelial marker cytokeratin 13	470:516	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	1	11	theme	epithelium	151:160	arg1	model					127:131	an engineered model	113:131	an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options	113:298	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	3	12	theme	intercellular	522:534	arg1	occludin					556:563	occludin	556:563	occludin	556:563	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	3	12	theme	intercellular	522:534	arg1	occludens-1					589:599	zonula occludens-1	582:599	zonula occludens-1	582:599	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	3	12	theme	intercellular	522:534	arg1	proteins					547:554	intercellular junctional proteins	522:554	intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1	522:599	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	3	12	theme	intercellular	522:534	arg1	E-cadherin					566:575	E-cadherin	566:575	E-cadherin	566:575	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	5	13	theme	matrix	871:876	arg1	stiffness					878:886	matrix stiffness	871:886	matrix stiffness	871:886	Our results show that matrix stiffness and composition cooperatively regulate the adhesion, proliferation, and stratification of VFECs.
33635635	7	14	theme	additional	1330:1339	arg1	layers					1358:1363	additional (1-2) suprabasal layers	1330:1363	additional (1-2) suprabasal layers	1330:1363	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers requires the presence of both RGDSP and AG73 peptide signals.
33635635	1	15	from	health	227:232	arg1	understanding					187:199	understanding	187:199	understanding of its role in vocal fold health, disease,	187:242	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	7	16	theme	layers	1358:1363	arg1	development					1258:1268	The development	1254:1268	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers	1254:1363	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers requires the presence of both RGDSP and AG73 peptide signals.
33635635	11	17	from	health	2111:2116	arg1	investigations					2046:2059	investigations	2046:2059	investigations of genetic and molecular mechanisms in vocal fold health and disease	2046:2128	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	7	18	with	epithelium	1284:1293	arg1	cells					1320:1324	proliferating basal cells	1300:1324	proliferating basal cells	1300:1324	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers requires the presence of both RGDSP and AG73 peptide signals.
33635635	11	19	theme	vocal	2100:2104	arg1	health					2111:2116	vocal fold health	2100:2116	vocal fold health	2100:2116	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	1	20	used	used	174:177	arg2	epithelium					151:160	the vocal fold epithelium	136:160	the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options	136:298	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	11	21	theme	mechanisms	2086:2095	arg1	investigations					2046:2059	investigations	2046:2059	investigations of genetic and molecular mechanisms in vocal fold health and disease	2046:2128	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	4	22	theme	hyaluronic	660:669	arg1	membrane					703:710	a hyaluronic acid-derived synthetic basement membrane	658:710	a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT)	658:846	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	11	23	from	disease	2122:2128	arg1	investigations					2046:2059	investigations	2046:2059	investigations of genetic and molecular mechanisms in vocal fold health and disease	2046:2128	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	1	24	from	role	208:211	arg1	health					227:232	vocal fold health	216:232	vocal fold health	216:232	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	11	25	used	used	2017:2020	arg2	tool					2037:2040	a versatile tool	2025:2040	a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease	2025:2128	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	11	25	used	used	2017:2020	arg2	epithelium					1999:2008	The engineered epithelium	1984:2008	The engineered epithelium	1984:2008	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	9	26	theme	tight/adherens	1716:1729	arg1	markers					1740:1746	tight/adherens junction markers	1716:1746	tight/adherens junction markers	1716:1746	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	8	27	theme	cytokines	1446:1454	arg1	Supplementation					1427:1441	Supplementation	1427:1441	Supplementation of cytokines produced by vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture	1427:1543	Supplementation of cytokines produced by vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture led to the establishment of 4-5 distinct cell layers.
33635635	4	28	theme	synthetic	684:692	arg1	membrane					703:710	a hyaluronic acid-derived synthetic basement membrane	658:710	a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT)	658:846	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	11	29	from	mechanisms	2086:2095	arg1	disease					2122:2128	disease	2122:2128	disease	2122:2128	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	11	29	from	mechanisms	2086:2095	arg1	health					2111:2116	vocal fold health	2100:2116	vocal fold health	2100:2116	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	3	30	theme	zonula	582:587	arg1	occludens-1					589:599	zonula occludens-1	582:599	zonula occludens-1	582:599	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	3	30	theme	zonula	582:587	arg1	proteins					547:554	intercellular junctional proteins	522:554	intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1	522:599	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	1	31	theme	engineered	116:125	arg1	model					127:131	an engineered model	113:131	an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options	113:298	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	7	32	theme	stratified	1273:1282	arg1	epithelium					1284:1293	stratified epithelium	1273:1293	stratified epithelium with proliferating basal cells	1273:1324	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers requires the presence of both RGDSP and AG73 peptide signals.
33635635	1	33	theme	new	278:280	arg1	options					292:298	new treatment options	278:298	new treatment options	278:298	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	11	34	theme	engineered	1988:1997	arg1	tool					2037:2040	a versatile tool	2025:2040	a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease	2025:2128	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	11	34	theme	engineered	1988:1997	arg1	epithelium					1999:2008	The engineered epithelium	1984:2008	The engineered epithelium	1984:2008	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	6	35	theme	physiological	1018:1030	arg1	stiffness					1032:1040	physiological stiffness	1018:1040	physiological stiffness (elastic shear modulus, G' = 1828 Pa)	1018:1078	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	8	36	theme	positive	1477:1484	arg1	fibroblasts					1513:1523	vimentin positive primary porcine vocal fold fibroblasts	1468:1523	vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture	1468:1543	Supplementation of cytokines produced by vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture led to the establishment of 4-5 distinct cell layers.
33635635	1	37	theme	options	292:298	arg1	development					263:273	the development	259:273	the development of new treatment options	259:298	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	1	38	theme	vocal	140:144	arg1	epithelium					151:160	the vocal fold epithelium	136:160	the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options	136:298	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	9	39	theme	basement	1762:1769	arg1	laminin					1805:1811	laminin 5	1805:1813	laminin 5	1805:1813	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	9	39	theme	basement	1762:1769	arg1	proteins					1780:1787	secreted basement membrane proteins collagen IV and laminin 5	1753:1813	secreted basement membrane proteins collagen IV and laminin 5	1753:1813	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	9	39	theme	basement	1762:1769	arg1	collagen					1789:1796	collagen IV	1789:1799	collagen IV	1789:1799	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	8	40	theme	porcine	1494:1500	arg1	fibroblasts					1513:1523	vimentin positive primary porcine vocal fold fibroblasts	1468:1523	vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture	1468:1543	Supplementation of cytokines produced by vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture led to the establishment of 4-5 distinct cell layers.
33635635	5	41	dep	adhesion	931:938	arg1	the					927:929	the	927:929	the	927:929	Our results show that matrix stiffness and composition cooperatively regulate the adhesion, proliferation, and stratification of VFECs.
33635635	7	42	theme	peptide	1410:1416	arg1	signals					1418:1424	both RGDSP and AG73 peptide signals	1390:1424	signals	1418:1424	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers requires the presence of both RGDSP and AG73 peptide signals.
33635635	5	43	theme	VFECs	978:982	arg1	proliferation					941:953	proliferation	941:953	proliferation	941:953	Our results show that matrix stiffness and composition cooperatively regulate the adhesion, proliferation, and stratification of VFECs.
33635635	5	43	theme	VFECs	978:982	arg1	stratification					960:973	stratification	960:973	stratification	960:973	Our results show that matrix stiffness and composition cooperatively regulate the adhesion, proliferation, and stratification of VFECs.
33635635	5	43	theme	VFECs	978:982	arg1	adhesion					931:938	adhesion	931:938	adhesion	931:938	Our results show that matrix stiffness and composition cooperatively regulate the adhesion, proliferation, and stratification of VFECs.
33635635	6	44	dep	=	1181:1181	arg1	41					1183:1184	41	1183:1184	41	1183:1184	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	8	45	theme	fold	1508:1511	arg1	fibroblasts					1513:1523	vimentin positive primary porcine vocal fold fibroblasts	1468:1523	vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture	1468:1543	Supplementation of cytokines produced by vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture led to the establishment of 4-5 distinct cell layers.
33635635	2	46	theme	vocal	339:343	arg1	VFECs					368:372	VFECs	368:372	VFECs	368:372	Toward this goal, we isolated primary vocal fold epithelial cells (VFECs) from healthy porcine larynxes and used them within passage 3.
33635635	2	46	theme	vocal	339:343	arg1	cells					361:365	primary vocal fold epithelial cells	331:365	primary vocal fold epithelial cells (VFECs)	331:373	Toward this goal, we isolated primary vocal fold epithelial cells (VFECs) from healthy porcine larynxes and used them within passage 3.
33635635	2	47	theme	healthy	380:386	arg1	larynxes					396:403	healthy porcine larynxes	380:403	healthy porcine larynxes	380:403	Toward this goal, we isolated primary vocal fold epithelial cells (VFECs) from healthy porcine larynxes and used them within passage 3.
33635635	6	48	dep	=	1069:1069	arg1	Pa					1076:1077	1828 Pa	1071:1077	1828 Pa	1071:1077	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	7	49	theme	proliferating	1300:1312	arg1	cells					1320:1324	proliferating basal cells	1300:1324	proliferating basal cells	1300:1324	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers requires the presence of both RGDSP and AG73 peptide signals.
33635635	8	50	theme	VFEC	1532:1535	arg1	culture					1537:1543	the VFEC culture	1528:1543	the VFEC culture	1528:1543	Supplementation of cytokines produced by vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture led to the establishment of 4-5 distinct cell layers.
33635635	4	51	theme	fibronectin-derived	723:741	arg1	peptide					760:766	fibronectin-derived integrin-binding peptide	723:766	fibronectin-derived integrin-binding peptide (RGDSP)	723:774	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	4	51	theme	fibronectin-derived	723:741	arg1	RGDSP					769:773	RGDSP	769:773	RGDSP	769:773	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	7	52	theme	RGDSP	1395:1399	arg1	presence					1378:1385	the presence	1374:1385	the presence of both RGDSP and AG73 peptide signals	1374:1424	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers requires the presence of both RGDSP and AG73 peptide signals.
33635635	7	53	theme	epithelium	1284:1293	arg1	development					1258:1268	The development	1254:1268	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers	1254:1363	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers requires the presence of both RGDSP and AG73 peptide signals.
33635635	6	54	dep	adopted	1080:1086	arg1	whereas					1144:1150	whereas	1144:1150	whereas	1144:1150	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	2	55	theme	epithelial	350:359	arg1	VFECs					368:372	VFECs	368:372	VFECs	368:372	Toward this goal, we isolated primary vocal fold epithelial cells (VFECs) from healthy porcine larynxes and used them within passage 3.
33635635	2	55	theme	epithelial	350:359	arg1	cells					361:365	primary vocal fold epithelial cells	331:365	primary vocal fold epithelial cells (VFECs)	331:373	Toward this goal, we isolated primary vocal fold epithelial cells (VFECs) from healthy porcine larynxes and used them within passage 3.
33635635	6	56	theme	shear	1051:1055	arg1	G					1066:1066	G'	1066:1067	G'	1066:1067	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	6	56	theme	shear	1051:1055	arg1	modulus					1057:1063	elastic shear modulus	1043:1063	elastic shear modulus	1043:1063	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	0	57	theme	Fold	46:49	arg1	Epithelium					51:60	Vocal Fold Epithelium	40:60	Vocal Fold Epithelium	40:60	Hydrogel-Supported, Engineered Model of Vocal Fold Epithelium.
33635635	6	58	theme	close	1118:1122	arg1	contacts					1134:1141	close cell-cell contacts	1118:1141	close cell-cell contacts	1118:1141	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	6	59	theme	G	1178:1178	arg1	matrices					1168:1175	softer matrices	1161:1175	softer matrices (G' = 41 Pa)	1161:1188	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	6	59	theme	G	1178:1178	arg1	Pa					1186:1187	G' = 41 Pa	1178:1187	G' = 41 Pa	1178:1187	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	10	60	theme	cell-matrix	1879:1889	arg1	engagement					1891:1900	cell-matrix engagement	1879:1900	cell-matrix engagement	1879:1900	Collectively, our results demonstrate that stiffness matching, cell-matrix engagement, and paracrine signaling cooperatively contribute to the stratification of VFECs.
33635635	0	61	dep	Engineered	20:29	arg1	Hydrogel-Supported					0:17	Hydrogel-Supported	0:17	Hydrogel-Supported	0:17	Hydrogel-Supported, Engineered Model of Vocal Fold Epithelium.
33635635	8	62	theme	distinct	1577:1584	arg1	layers					1591:1596	4-5 distinct cell layers	1573:1596	4-5 distinct cell layers	1573:1596	Supplementation of cytokines produced by vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture led to the establishment of 4-5 distinct cell layers.
33635635	10	63	theme	matching	1869:1876	arg1	stiffness					1859:1867	stiffness matching	1859:1876	stiffness matching	1859:1876	Collectively, our results demonstrate that stiffness matching, cell-matrix engagement, and paracrine signaling cooperatively contribute to the stratification of VFECs.
33635635	4	64	theme	111-derived	791:801	arg1	peptide					820:826	laminin 111-derived syndecan-binding peptide AG73	783:831	laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT)	783:846	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	4	64	theme	111-derived	791:801	arg1	RKRLQVQLSIRT					834:845	RKRLQVQLSIRT	834:845	RKRLQVQLSIRT	834:845	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	3	65	dep	proteins	547:554	arg1	occludin					556:563	occludin	556:563	occludin	556:563	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	3	65	dep	proteins	547:554	arg1	occludens-1					589:599	zonula occludens-1	582:599	zonula occludens-1	582:599	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	3	65	dep	proteins	547:554	arg1	proteins					547:554	intercellular junctional proteins	522:554	intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1	522:599	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	3	65	dep	proteins	547:554	arg1	E-cadherin					566:575	E-cadherin	566:575	E-cadherin	566:575	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	8	66	from	fibroblasts	1513:1523	arg1	culture					1537:1543	the VFEC culture	1528:1543	the VFEC culture	1528:1543	Supplementation of cytokines produced by vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture led to the establishment of 4-5 distinct cell layers.
33635635	9	67	theme	fold	1620:1623	arg1	epithelium					1625:1634	The engineered vocal fold epithelium	1599:1634	The engineered vocal fold epithelium	1599:1634	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	8	68	theme	layers	1591:1596	arg1	establishment					1556:1568	the establishment	1552:1568	the establishment of 4-5 distinct cell layers	1552:1596	Supplementation of cytokines produced by vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture led to the establishment of 4-5 distinct cell layers.
33635635	10	69	theme	paracrine	1907:1915	arg1	signaling					1917:1925	paracrine signaling	1907:1925	paracrine signaling	1907:1925	Collectively, our results demonstrate that stiffness matching, cell-matrix engagement, and paracrine signaling cooperatively contribute to the stratification of VFECs.
33635635	6	70	with	shaped	1203:1208	arg1	fibers					1246:1251	extensive intracellular stress fibers	1215:1251	extensive intracellular stress fibers	1215:1251	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	2	71	used	used	409:412	arg2	we					319:320	we	319:320	we	319:320	Toward this goal, we isolated primary vocal fold epithelial cells (VFECs) from healthy porcine larynxes and used them within passage 3.
33635635	3	72	theme	epithelial	485:494	arg1	cytokeratin					503:513	the suprabasal epithelial marker cytokeratin 13	470:516	the suprabasal epithelial marker cytokeratin 13	470:516	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	1	73	theme	fold	222:225	arg1	health					227:232	vocal fold health	216:232	vocal fold health	216:232	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	4	74	link	acid-derived	671:682	arg1	membrane					703:710	a hyaluronic acid-derived synthetic basement membrane	658:710	a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT)	658:846	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	6	75	theme	intracellular	1225:1237	arg1	fibers					1246:1251	extensive intracellular stress fibers	1215:1251	extensive intracellular stress fibers	1215:1251	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	1	76	theme	fold	146:149	arg1	epithelium					151:160	the vocal fold epithelium	136:160	the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options	136:298	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	7	77	theme	signals	1418:1424	arg1	presence					1378:1385	the presence	1374:1385	the presence of both RGDSP and AG73 peptide signals	1374:1424	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers requires the presence of both RGDSP and AG73 peptide signals.
33635635	10	78	theme	VFECs	1977:1981	arg1	stratification					1959:1972	the stratification	1955:1972	the stratification of VFECs	1955:1981	Collectively, our results demonstrate that stiffness matching, cell-matrix engagement, and paracrine signaling cooperatively contribute to the stratification of VFECs.
33635635	11	79	theme	versatile	2027:2035	arg1	tool					2037:2040	a versatile tool	2025:2040	a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease	2025:2128	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	11	79	theme	versatile	2027:2035	arg1	epithelium					1999:2008	The engineered epithelium	1984:2008	The engineered epithelium	1984:2008	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	11	80	theme	molecular	2076:2084	arg1	mechanisms					2086:2095	genetic and molecular mechanisms	2064:2095	genetic and molecular mechanisms in vocal fold health and disease	2064:2128	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	11	81	theme	genetic	2064:2070	arg1	mechanisms					2086:2095	genetic and molecular mechanisms	2064:2095	genetic and molecular mechanisms in vocal fold health and disease	2064:2128	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	9	82	dep	proteins	1780:1787	arg1	laminin					1805:1811	laminin 5	1805:1813	laminin 5	1805:1813	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	9	82	dep	proteins	1780:1787	arg1	proteins					1780:1787	secreted basement membrane proteins collagen IV and laminin 5	1753:1813	secreted basement membrane proteins collagen IV and laminin 5	1753:1813	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	9	82	dep	proteins	1780:1787	arg1	collagen					1789:1796	collagen IV	1789:1799	collagen IV	1789:1799	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	3	83	theme	junctional	536:545	arg1	occludin					556:563	occludin	556:563	occludin	556:563	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	3	83	theme	junctional	536:545	arg1	occludens-1					589:599	zonula occludens-1	582:599	zonula occludens-1	582:599	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	3	83	theme	junctional	536:545	arg1	proteins					547:554	intercellular junctional proteins	522:554	intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1	522:599	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	3	83	theme	junctional	536:545	arg1	E-cadherin					566:575	E-cadherin	566:575	E-cadherin	566:575	Culture-expanded VFECs expressed the suprabasal epithelial marker cytokeratin 13 and intercellular junctional proteins occludin, E-cadherin, and zonula occludens-1.
33635635	11	84	theme	fold	2106:2109	arg1	health					2111:2116	vocal fold health	2100:2116	vocal fold health	2100:2116	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	7	85	theme	suprabasal	1347:1356	arg1	layers					1358:1363	additional (1-2) suprabasal layers	1330:1363	additional (1-2) suprabasal layers	1330:1363	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers requires the presence of both RGDSP and AG73 peptide signals.
33635635	1	86	from	understanding	187:199	arg1	health					227:232	vocal fold health	216:232	vocal fold health	216:232	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	6	87	theme	elastic	1043:1049	arg1	G					1066:1066	G'	1066:1067	G'	1066:1067	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	6	87	theme	elastic	1043:1049	arg1	modulus					1057:1063	elastic shear modulus	1043:1063	elastic shear modulus	1043:1063	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	9	88	theme	junction	1731:1738	arg1	markers					1740:1746	tight/adherens junction markers	1716:1746	tight/adherens junction markers	1716:1746	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	8	89	theme	vimentin	1468:1475	arg1	fibroblasts					1513:1523	vimentin positive primary porcine vocal fold fibroblasts	1468:1523	vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture	1468:1543	Supplementation of cytokines produced by vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture led to the establishment of 4-5 distinct cell layers.
33635635	6	90	theme	=	1181:1181	arg1	matrices					1168:1175	softer matrices	1161:1175	softer matrices (G' = 41 Pa)	1161:1188	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	6	90	theme	=	1181:1181	arg1	Pa					1186:1187	G' = 41 Pa	1178:1187	G' = 41 Pa	1178:1187	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	4	91	theme	acid-derived	671:682	arg1	membrane					703:710	a hyaluronic acid-derived synthetic basement membrane	658:710	a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT)	658:846	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	1	92	theme	model	127:131	arg1	establishment					96:108	the establishment	92:108	the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options	92:298	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	8	93	theme	primary	1486:1492	arg1	fibroblasts					1513:1523	vimentin positive primary porcine vocal fold fibroblasts	1468:1523	vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture	1468:1543	Supplementation of cytokines produced by vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture led to the establishment of 4-5 distinct cell layers.
33635635	6	94	with	hydrogels	1003:1011	arg1	stiffness					1032:1040	physiological stiffness	1018:1040	physiological stiffness (elastic shear modulus, G' = 1828 Pa)	1018:1078	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	1	95	theme	treatment	282:290	arg1	options					292:298	new treatment options	278:298	new treatment options	278:298	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	9	96	theme	secreted	1753:1760	arg1	laminin					1805:1811	laminin 5	1805:1813	laminin 5	1805:1813	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	9	96	theme	secreted	1753:1760	arg1	proteins					1780:1787	secreted basement membrane proteins collagen IV and laminin 5	1753:1813	secreted basement membrane proteins collagen IV and laminin 5	1753:1813	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	9	96	theme	secreted	1753:1760	arg1	collagen					1789:1796	collagen IV	1789:1799	collagen IV	1789:1799	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	8	97	theme	vocal	1502:1506	arg1	fibroblasts					1513:1523	vimentin positive primary porcine vocal fold fibroblasts	1468:1523	vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture	1468:1543	Supplementation of cytokines produced by vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture led to the establishment of 4-5 distinct cell layers.
33635635	9	98	theme	engineered	1603:1612	arg1	epithelium					1625:1634	The engineered vocal fold epithelium	1599:1634	The engineered vocal fold epithelium	1599:1634	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	9	99	theme	membrane	1771:1778	arg1	laminin					1805:1811	laminin 5	1805:1813	laminin 5	1805:1813	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	9	99	theme	membrane	1771:1778	arg1	proteins					1780:1787	secreted basement membrane proteins collagen IV and laminin 5	1753:1813	secreted basement membrane proteins collagen IV and laminin 5	1753:1813	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	9	99	theme	membrane	1771:1778	arg1	collagen					1789:1796	collagen IV	1789:1799	collagen IV	1789:1799	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	6	100	dep	stiffness	1032:1040	arg1	G					1066:1066	G'	1066:1067	G'	1066:1067	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	6	100	dep	stiffness	1032:1040	arg1	modulus					1057:1063	elastic shear modulus	1043:1063	elastic shear modulus	1043:1063	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	4	101	theme	integrin-binding	743:758	arg1	peptide					760:766	fibronectin-derived integrin-binding peptide	723:766	fibronectin-derived integrin-binding peptide (RGDSP)	723:774	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	4	101	theme	integrin-binding	743:758	arg1	RGDSP					769:773	RGDSP	769:773	RGDSP	769:773	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	7	102	with	layers	1358:1363	arg1	cells					1320:1324	proliferating basal cells	1300:1324	proliferating basal cells	1300:1324	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers requires the presence of both RGDSP and AG73 peptide signals.
33635635	7	103	theme	basal	1314:1318	arg1	cells					1320:1324	proliferating basal cells	1300:1324	proliferating basal cells	1300:1324	The development of stratified epithelium with proliferating basal cells and additional (1-2) suprabasal layers requires the presence of both RGDSP and AG73 peptide signals.
33635635	2	104	theme	primary	331:337	arg1	VFECs					368:372	VFECs	368:372	VFECs	368:372	Toward this goal, we isolated primary vocal fold epithelial cells (VFECs) from healthy porcine larynxes and used them within passage 3.
33635635	2	104	theme	primary	331:337	arg1	cells					361:365	primary vocal fold epithelial cells	331:365	primary vocal fold epithelial cells (VFECs)	331:373	Toward this goal, we isolated primary vocal fold epithelial cells (VFECs) from healthy porcine larynxes and used them within passage 3.
33635635	1	105	theme	critical	74:81	arg1	need					83:86	a critical need	72:86	a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options	72:298	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
33635635	6	106	theme	=	1069:1069	arg1	G					1066:1066	G'	1066:1067	G'	1066:1067	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	6	106	theme	=	1069:1069	arg1	modulus					1057:1063	elastic shear modulus	1043:1063	elastic shear modulus	1043:1063	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	4	107	theme	basement	694:701	arg1	membrane					703:710	a hyaluronic acid-derived synthetic basement membrane	658:710	a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT)	658:846	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	4	108	link	111-derived	791:801	arg1	peptide					820:826	laminin 111-derived syndecan-binding peptide AG73	783:831	laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT)	783:846	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	4	108	link	111-derived	791:801	arg1	RKRLQVQLSIRT					834:845	RKRLQVQLSIRT	834:845	RKRLQVQLSIRT	834:845	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	6	109	theme	cobblestone	1090:1100	arg1	morphology					1102:1111	a cobblestone morphology	1088:1111	a cobblestone morphology with close cell-cell contacts	1088:1141	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	0	110	theme	Vocal	40:44	arg1	Epithelium					51:60	Vocal Fold Epithelium	40:60	Vocal Fold Epithelium	40:60	Hydrogel-Supported, Engineered Model of Vocal Fold Epithelium.
33635635	4	111	theme	syndecan-binding	803:818	arg1	peptide					820:826	laminin 111-derived syndecan-binding peptide AG73	783:831	laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT)	783:846	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	4	111	theme	syndecan-binding	803:818	arg1	RKRLQVQLSIRT					834:845	RKRLQVQLSIRT	834:845	RKRLQVQLSIRT	834:845	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	2	112	theme	fold	345:348	arg1	VFECs					368:372	VFECs	368:372	VFECs	368:372	Toward this goal, we isolated primary vocal fold epithelial cells (VFECs) from healthy porcine larynxes and used them within passage 3.
33635635	2	112	theme	fold	345:348	arg1	cells					361:365	primary vocal fold epithelial cells	331:365	primary vocal fold epithelial cells (VFECs)	331:373	Toward this goal, we isolated primary vocal fold epithelial cells (VFECs) from healthy porcine larynxes and used them within passage 3.
33635635	0	113	theme	Epithelium	51:60	arg1	Model					31:35	Model	31:35	Model of Vocal Fold Epithelium	31:60	Hydrogel-Supported, Engineered Model of Vocal Fold Epithelium.
33635635	6	114	theme	cell-cell	1124:1132	arg1	contacts					1134:1141	close cell-cell contacts	1118:1141	close cell-cell contacts	1118:1141	Cells cultured on hydrogels with physiological stiffness (elastic shear modulus, G' = 1828 Pa) adopted a cobblestone morphology with close cell-cell contacts, whereas those on softer matrices (G' = 41 Pa) were spindle shaped with extensive intracellular stress fibers.
33635635	2	115	theme	porcine	388:394	arg1	larynxes					396:403	healthy porcine larynxes	380:403	healthy porcine larynxes	380:403	Toward this goal, we isolated primary vocal fold epithelial cells (VFECs) from healthy porcine larynxes and used them within passage 3.
33635635	8	116	theme	cell	1586:1589	arg1	layers					1591:1596	4-5 distinct cell layers	1573:1596	4-5 distinct cell layers	1573:1596	Supplementation of cytokines produced by vimentin positive primary porcine vocal fold fibroblasts in the VFEC culture led to the establishment of 4-5 distinct cell layers.
33635635	9	117	theme	vocal	1614:1618	arg1	epithelium					1625:1634	The engineered vocal fold epithelium	1599:1634	The engineered vocal fold epithelium	1599:1634	The engineered vocal fold epithelium resembled native tissue morphologically; expressed cytokeratin 13, mucin 1, and tight/adherens junction markers; and secreted basement membrane proteins collagen IV and laminin 5.
33635635	4	118	link	fibronectin-derived	723:741	arg1	peptide					760:766	fibronectin-derived integrin-binding peptide	723:766	fibronectin-derived integrin-binding peptide (RGDSP)	723:774	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	4	118	link	fibronectin-derived	723:741	arg1	RGDSP					769:773	RGDSP	769:773	RGDSP	769:773	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	11	119	from	investigations	2046:2059	arg1	disease					2122:2128	disease	2122:2128	disease	2122:2128	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	11	119	from	investigations	2046:2059	arg1	health					2111:2116	vocal fold health	2100:2116	vocal fold health	2100:2116	The engineered epithelium can be used as a versatile tool for investigations of genetic and molecular mechanisms in vocal fold health and disease.
33635635	4	120	theme	laminin	783:789	arg1	peptide					820:826	laminin 111-derived syndecan-binding peptide AG73	783:831	laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT)	783:846	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	4	120	theme	laminin	783:789	arg1	RKRLQVQLSIRT					834:845	RKRLQVQLSIRT	834:845	RKRLQVQLSIRT	834:845	To establish the engineered model, we cultured VFECs on a hyaluronic acid-derived synthetic basement membrane displaying fibronectin-derived integrin-binding peptide (RGDSP) and/or laminin 111-derived syndecan-binding peptide AG73 (RKRLQVQLSIRT).
33635635	1	121	theme	role	208:211	arg1	understanding					187:199	understanding	187:199	understanding of its role in vocal fold health, disease,	187:242	There is a critical need for the establishment of an engineered model of the vocal fold epithelium that can be used to gain understanding of its role in vocal fold health, disease, and facilitate the development of new treatment options.
32027992	2	0	theme	properties	360:369	arg1	terms					324:328	terms	324:328	terms of composition and mechanical properties	324:369	The selection of a suitable bioink, in terms of composition and mechanical properties, is crucial for the development of viable cartilage substitutes.
32027992	1	1	theme	cartilage	274:282	arg1	regeneration					248:259	regeneration	248:259	regeneration	248:259	Bioprinting is a promising tool to fabricate well-organized cell-laden constructs for repair and regeneration of articular cartilage.
32027992	1	1	theme	cartilage	274:282	arg1	repair					237:242	repair	237:242	repair	237:242	Bioprinting is a promising tool to fabricate well-organized cell-laden constructs for repair and regeneration of articular cartilage.
32027992	9	2	from	crucial	1520:1526	arg1	attempt					1416:1422	this attempt	1411:1422	this attempt	1411:1422	In this attempt, the selection of a suitable biomaterial, in terms of composition and mechanical properties, is crucial.
32027992	9	2	from	crucial	1520:1526	arg1	terms					1469:1473	terms	1469:1473	terms of composition and mechanical properties	1469:1514	In this attempt, the selection of a suitable biomaterial, in terms of composition and mechanical properties, is crucial.
32027992	7	3	theme	promising	1084:1092	arg1	it					1076:1077	it	1076:1077	it	1076:1077	These results indicate that it is a promising bioink candidate for cartilage tissue engineering based in 3D bioprinting.
32027992	7	3	theme	promising	1084:1092	arg1	candidate					1101:1109	a promising bioink candidate	1082:1109	a promising bioink candidate for cartilage tissue engineering based in 3D bioprinting	1082:1166	These results indicate that it is a promising bioink candidate for cartilage tissue engineering based in 3D bioprinting.
32027992	10	4	theme	toxic	1715:1719	arg1	procedure					1721:1729	toxic procedure	1715:1729	toxic procedure	1715:1729	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	5	5	with	constructs	759:768	arg1	properties					794:803	optimal mechanical properties	775:803	optimal mechanical properties	775:803	To produce cartilage constructs with optimal mechanical properties, HA-based bioink was co-printed with polylactic acid (PLA).
32027992	8	6	theme	3D	1221:1222	arg1	technology					1233:1242	3D printing technology	1221:1242	3D printing technology	1221:1242	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	3	7	theme	hyaluronic	514:523	arg1	acid					525:528	hyaluronic acid	514:528	hyaluronic acid (HA)	514:533	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
32027992	3	7	theme	hyaluronic	514:523	arg1	one					476:478	one	476:478	one	476:478	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
32027992	3	7	theme	hyaluronic	514:523	arg1	HA					531:532	HA	531:532	HA	531:532	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
32027992	3	7	theme	hyaluronic	514:523	arg1	components					502:511	the main cartilage components	483:511	the main cartilage components	483:511	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
32027992	8	8	theme	technology	1233:1242	arg1	appearance					1207:1216	The recent appearance	1196:1216	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology	1169:1242	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	9	9	theme	suitable	1444:1451	arg1	biomaterial					1453:1463	a suitable biomaterial	1442:1463	a suitable biomaterial	1442:1463	In this attempt, the selection of a suitable biomaterial, in terms of composition and mechanical properties, is crucial.
32027992	8	10	theme	SIGNIFICANCE	1182:1193	arg1	STATEMENT					1169:1177	STATEMENT	1169:1177	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology	1169:1242	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	10	11	theme	first	1560:1564	arg1	time					1566:1569	first time	1560:1569	first time	1560:1569	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	0	12	theme	articular	107:115	arg1	cartilage					117:125	articular cartilage	107:125	articular cartilage engineering constructs	107:148	Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs.
32027992	2	13	theme	bioink	313:318	arg1	selection					289:297	The selection	285:297	The selection	285:297	The selection of a suitable bioink, in terms of composition and mechanical properties, is crucial for the development of viable cartilage substitutes.
32027992	2	13	theme	bioink	313:318	arg1	crucial					375:381	crucial	375:381	crucial	375:381	The selection of a suitable bioink, in terms of composition and mechanical properties, is crucial for the development of viable cartilage substitutes.
32027992	1	14	theme	cell-laden	211:220	arg1	constructs					222:231	well-organized cell-laden constructs	196:231	well-organized cell-laden constructs	196:231	Bioprinting is a promising tool to fabricate well-organized cell-laden constructs for repair and regeneration of articular cartilage.
32027992	12	15	theme	clinical	2096:2103	arg1	arena					2105:2109	the clinical arena	2092:2109	the clinical arena	2092:2109	We highlight the translation potential of this HA-based bioink in the clinical arena.
32027992	10	16	theme	bioink	1592:1597	arg1	development					1575:1585	the development	1571:1585	the development of a bioink based on the main component of cartilage, HA	1571:1642	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	10	17	theme	tissue	1765:1770	arg1	bioprinting					1772:1782	cartilage tissue bioprinting	1755:1782	cartilage tissue bioprinting	1755:1782	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	5	18	theme	polylactic	842:851	arg1	PLA					859:861	PLA	859:861	PLA	859:861	To produce cartilage constructs with optimal mechanical properties, HA-based bioink was co-printed with polylactic acid (PLA).
32027992	5	18	theme	polylactic	842:851	arg1	acid					853:856	polylactic acid	842:856	polylactic acid (PLA)	842:862	To produce cartilage constructs with optimal mechanical properties, HA-based bioink was co-printed with polylactic acid (PLA).
32027992	9	19	theme	composition	1478:1488	arg1	terms					1469:1473	terms	1469:1473	terms of composition and mechanical properties	1469:1514	In this attempt, the selection of a suitable biomaterial, in terms of composition and mechanical properties, is crucial.
32027992	12	20	theme	HA-based	2073:2080	arg1	bioink					2082:2087	this HA-based bioink	2068:2087	this HA-based bioink	2068:2087	We highlight the translation potential of this HA-based bioink in the clinical arena.
32027992	3	21	theme	cartilage	577:585	arg1	bioprinting					597:607	cartilage tissue 3D bioprinting	577:607	cartilage tissue 3D bioprinting	577:607	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
32027992	8	22	from	advances	1262:1269	arg1	treatment					1278:1286	the treatment	1274:1286	the treatment of osteochondral disorders	1274:1313	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	9	23	theme	mechanical	1494:1503	arg1	properties					1505:1514	mechanical properties	1494:1514	mechanical properties	1494:1514	In this attempt, the selection of a suitable biomaterial, in terms of composition and mechanical properties, is crucial.
32027992	10	24	from	procedure	1721:1729	arg1	bioprinting					1772:1782	cartilage tissue bioprinting	1755:1782	cartilage tissue bioprinting	1755:1782	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	6	25	theme	deposition	1003:1012	arg1	expression					943:952	the expression	939:952	the expression of chondrogenic gene markers and specific matrix deposition	939:1012	HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation.
32027992	6	25	theme	deposition	1003:1012	arg1	formation					1037:1045	tissue formation	1030:1045	tissue formation	1030:1045	HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation.
32027992	8	26	theme	disorders	1305:1313	arg1	treatment					1278:1286	the treatment	1274:1286	the treatment of osteochondral disorders	1274:1313	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	6	27	theme	specific	987:994	arg1	deposition					1003:1012	specific matrix deposition	987:1012	specific matrix deposition	987:1012	HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation.
32027992	12	28	theme	translation	2043:2053	arg1	potential					2055:2063	the translation potential	2039:2063	the translation potential of this HA-based bioink in the clinical arena	2039:2109	We highlight the translation potential of this HA-based bioink in the clinical arena.
32027992	0	29	theme	potential	68:76	arg1	bioink					78:83	a potential bioink	66:83	a potential bioink for 3D bioprinting of articular cartilage engineering constructs	66:148	Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs.
32027992	10	30	from	application	1740:1750	arg1	bioprinting					1772:1782	cartilage tissue bioprinting	1755:1782	cartilage tissue bioprinting	1755:1782	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	6	31	theme	markers	975:981	arg1	expression					943:952	the expression	939:952	the expression of chondrogenic gene markers and specific matrix deposition	939:1012	HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation.
32027992	6	31	theme	markers	975:981	arg1	formation					1037:1045	tissue formation	1030:1045	tissue formation	1030:1045	HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation.
32027992	8	32	theme	cartilage	1333:1341	arg1	constructs					1350:1359	cartilage tissue constructs	1333:1359	cartilage tissue constructs that restore and/or regenerate damaged tissue	1333:1405	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	6	33	theme	chondrogenic	957:968	arg1	markers					975:981	chondrogenic gene markers	957:981	chondrogenic gene markers	957:981	HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation.
32027992	8	34	theme	constructs	1350:1359	arg1	fabrication					1318:1328	fabrication	1318:1328	fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue	1318:1405	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	11	35	theme	optimal	1881:1887	arg1	niche					1889:1893	an optimal niche	1878:1893	an optimal niche for chondrocyte growth and maintenance as well as mechanical properties necessary to support load forces exerted in native tissue	1878:2023	Hybrid constructs prepared by co-printing this bioink and thermoplastic polymer PLA provided an optimal niche for chondrocyte growth and maintenance as well as mechanical properties necessary to support load forces exerted in native tissue.
32027992	0	36	theme	Bio-inspired	0:11	arg1	hydrogel					13:20	Bio-inspired hydrogel	0:20	Bio-inspired hydrogel	0:20	Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs.
32027992	11	37	theme	mechanical	1945:1954	arg1	properties					1956:1965	mechanical properties	1945:1965	mechanical properties necessary to support load forces exerted in native tissue	1945:2023	Hybrid constructs prepared by co-printing this bioink and thermoplastic polymer PLA provided an optimal niche for chondrocyte growth and maintenance as well as mechanical properties necessary to support load forces exerted in native tissue.
32027992	2	38	theme	cartilage	413:421	arg1	development					391:401	the development	387:401	the development of viable cartilage substitutes	387:433	The selection of a suitable bioink, in terms of composition and mechanical properties, is crucial for the development of viable cartilage substitutes.
32027992	2	39	dep	cartilage	413:421	arg1	substitutes					423:433	substitutes	423:433	substitutes	423:433	The selection of a suitable bioink, in terms of composition and mechanical properties, is crucial for the development of viable cartilage substitutes.
32027992	10	40	theme	cartilage	1630:1638	arg1	component					1617:1625	the main component	1608:1625	the main component of cartilage	1608:1638	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	10	40	theme	cartilage	1630:1638	arg1	HA					1641:1642	HA	1641:1642	HA	1641:1642	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	0	41	theme	hyaluronic	34:43	arg1	acid					45:48	hyaluronic acid	34:48	hyaluronic acid	34:48	Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs.
32027992	9	42	from	attempt	1416:1422	arg1	selection					1429:1437	the selection	1425:1437	the selection of a suitable biomaterial	1425:1463	In this attempt, the selection of a suitable biomaterial, in terms of composition and mechanical properties, is crucial.
32027992	9	42	from	attempt	1416:1422	arg1	crucial					1520:1526	crucial	1520:1526	crucial	1520:1526	In this attempt, the selection of a suitable biomaterial, in terms of composition and mechanical properties, is crucial.
32027992	3	43	theme	3D	594:595	arg1	bioprinting					597:607	cartilage tissue 3D bioprinting	577:607	cartilage tissue 3D bioprinting	577:607	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
32027992	2	44	theme	mechanical	349:358	arg1	properties					360:369	mechanical properties	349:369	mechanical properties	349:369	The selection of a suitable bioink, in terms of composition and mechanical properties, is crucial for the development of viable cartilage substitutes.
32027992	3	45	theme	one	476:478	arg1	use					469:471	the use	465:471	the use of one of the main cartilage components, hyaluronic acid (HA), to design	465:544	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
32027992	7	46	theme	cartilage	1115:1123	arg1	engineering					1132:1142	cartilage tissue engineering	1115:1142	cartilage tissue engineering based in 3D bioprinting	1115:1166	These results indicate that it is a promising bioink candidate for cartilage tissue engineering based in 3D bioprinting.
32027992	8	47	dep	STATEMENT	1169:1177	arg1	appearance					1207:1216	The recent appearance	1196:1216	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology	1169:1242	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	2	48	theme	composition	333:343	arg1	terms					324:328	terms	324:328	terms of composition and mechanical properties	324:369	The selection of a suitable bioink, in terms of composition and mechanical properties, is crucial for the development of viable cartilage substitutes.
32027992	11	49	theme	load	1988:1991	arg1	forces					1993:1998	support load forces	1980:1998	support load forces exerted in native tissue	1980:2023	Hybrid constructs prepared by co-printing this bioink and thermoplastic polymer PLA provided an optimal niche for chondrocyte growth and maintenance as well as mechanical properties necessary to support load forces exerted in native tissue.
32027992	11	50	theme	chondrocyte	1899:1909	arg1	growth					1911:1916	growth	1911:1916	growth	1911:1916	Hybrid constructs prepared by co-printing this bioink and thermoplastic polymer PLA provided an optimal niche for chondrocyte growth and maintenance as well as mechanical properties necessary to support load forces exerted in native tissue.
32027992	3	51	theme	cartilage	492:500	arg1	components					502:511	the main cartilage components	483:511	the main cartilage components	483:511	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
32027992	6	52	theme	cell	902:905	arg1	functionality					907:919	cell functionality	902:919	cell functionality	902:919	HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation.
32027992	7	53	theme	bioink	1094:1099	arg1	it					1076:1077	it	1076:1077	it	1076:1077	These results indicate that it is a promising bioink candidate for cartilage tissue engineering based in 3D bioprinting.
32027992	7	53	theme	bioink	1094:1099	arg1	candidate					1101:1109	a promising bioink candidate	1082:1109	a promising bioink candidate for cartilage tissue engineering based in 3D bioprinting	1082:1166	These results indicate that it is a promising bioink candidate for cartilage tissue engineering based in 3D bioprinting.
32027992	10	54	theme	mechanical	1674:1683	arg1	properties					1685:1694	suitable biological and mechanical properties	1650:1694	suitable biological and mechanical properties	1650:1694	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	1	55	theme	articular	264:272	arg1	cartilage					274:282	articular cartilage	264:282	articular cartilage	264:282	Bioprinting is a promising tool to fabricate well-organized cell-laden constructs for repair and regeneration of articular cartilage.
32027992	2	56	theme	suitable	304:311	arg1	bioink					313:318	a suitable bioink	302:318	a suitable bioink	302:318	The selection of a suitable bioink, in terms of composition and mechanical properties, is crucial for the development of viable cartilage substitutes.
32027992	10	57	theme	biological	1659:1668	arg1	properties					1685:1694	suitable biological and mechanical properties	1650:1694	suitable biological and mechanical properties	1650:1694	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	11	58	theme	support	1980:1986	arg1	forces					1993:1998	support load forces	1980:1998	support load forces exerted in native tissue	1980:2023	Hybrid constructs prepared by co-printing this bioink and thermoplastic polymer PLA provided an optimal niche for chondrocyte growth and maintenance as well as mechanical properties necessary to support load forces exerted in native tissue.
32027992	1	59	theme	promising	168:176	arg1	Bioprinting					151:161	Bioprinting	151:161	Bioprinting	151:161	Bioprinting is a promising tool to fabricate well-organized cell-laden constructs for repair and regeneration of articular cartilage.
32027992	1	59	theme	promising	168:176	arg1	tool					178:181	a promising tool	166:181	a promising tool to fabricate well-organized cell-laden constructs for repair and regeneration of articular cartilage	166:282	Bioprinting is a promising tool to fabricate well-organized cell-laden constructs for repair and regeneration of articular cartilage.
32027992	5	60	theme	mechanical	783:792	arg1	properties					794:803	optimal mechanical properties	775:803	optimal mechanical properties	775:803	To produce cartilage constructs with optimal mechanical properties, HA-based bioink was co-printed with polylactic acid (PLA).
32027992	6	61	theme	HA-based	865:872	arg1	bioink					874:879	HA-based bioink	865:879	HA-based bioink	865:879	HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation.
32027992	4	62	theme	Major	610:614	arg1	characteristics					616:630	Major characteristics	610:630	Major characteristics required for this application such as printability, biocompatibility, and biodegradability	610:721	Major characteristics required for this application such as printability, biocompatibility, and biodegradability were analyzed.
32027992	5	63	theme	cartilage	749:757	arg1	constructs					759:768	cartilage constructs	749:768	cartilage constructs with optimal mechanical properties	749:803	To produce cartilage constructs with optimal mechanical properties, HA-based bioink was co-printed with polylactic acid (PLA).
32027992	8	64	theme	printing	1224:1231	arg1	technology					1233:1242	3D printing technology	1221:1242	3D printing technology	1221:1242	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	0	65	theme	cartilage	117:125	arg1	bioprinting					92:102	3D bioprinting	89:102	3D bioprinting of articular cartilage engineering constructs	89:148	Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs.
32027992	9	66	theme	biomaterial	1453:1463	arg1	selection					1429:1437	the selection	1425:1437	the selection of a suitable biomaterial	1425:1463	In this attempt, the selection of a suitable biomaterial, in terms of composition and mechanical properties, is crucial.
32027992	9	66	theme	biomaterial	1453:1463	arg1	crucial					1520:1526	crucial	1520:1526	crucial	1520:1526	In this attempt, the selection of a suitable biomaterial, in terms of composition and mechanical properties, is crucial.
32027992	12	67	theme	bioink	2082:2087	arg1	potential					2055:2063	the translation potential	2039:2063	the translation potential of this HA-based bioink in the clinical arena	2039:2109	We highlight the translation potential of this HA-based bioink in the clinical arena.
32027992	8	68	theme	great	1256:1260	arg1	advances					1262:1269	great advances	1256:1269	great advances in the treatment of osteochondral disorders	1256:1313	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	10	69	theme	cartilage	1755:1763	arg1	bioprinting					1772:1782	cartilage tissue bioprinting	1755:1782	cartilage tissue bioprinting	1755:1782	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	6	70	from	increase	927:934	arg1	expression					943:952	the expression	939:952	the expression of chondrogenic gene markers and specific matrix deposition	939:1012	HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation.
32027992	6	70	from	increase	927:934	arg1	formation					1037:1045	tissue formation	1030:1045	tissue formation	1030:1045	HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation.
32027992	8	71	theme	recent	1200:1205	arg1	appearance					1207:1216	The recent appearance	1196:1216	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology	1169:1242	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	11	72	theme	Hybrid	1785:1790	arg1	constructs					1792:1801	Hybrid constructs	1785:1801	Hybrid constructs prepared by co-printing this bioink and thermoplastic polymer PLA	1785:1867	Hybrid constructs prepared by co-printing this bioink and thermoplastic polymer PLA provided an optimal niche for chondrocyte growth and maintenance as well as mechanical properties necessary to support load forces exerted in native tissue.
32027992	11	73	theme	necessary	1967:1975	arg1	properties					1956:1965	mechanical properties	1945:1965	mechanical properties necessary to support load forces exerted in native tissue	1945:2023	Hybrid constructs prepared by co-printing this bioink and thermoplastic polymer PLA provided an optimal niche for chondrocyte growth and maintenance as well as mechanical properties necessary to support load forces exerted in native tissue.
32027992	12	74	from	potential	2055:2063	arg1	arena					2105:2109	the clinical arena	2092:2109	the clinical arena	2092:2109	We highlight the translation potential of this HA-based bioink in the clinical arena.
32027992	2	75	from	selection	289:297	arg1	terms					324:328	terms	324:328	terms of composition and mechanical properties	324:369	The selection of a suitable bioink, in terms of composition and mechanical properties, is crucial for the development of viable cartilage substitutes.
32027992	3	76	theme	new	562:564	arg1	bioink					566:571	a new bioink	560:571	a new bioink for cartilage tissue 3D bioprinting	560:607	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
32027992	1	77	theme	well-organized	196:209	arg1	constructs					222:231	well-organized cell-laden constructs	196:231	well-organized cell-laden constructs	196:231	Bioprinting is a promising tool to fabricate well-organized cell-laden constructs for repair and regeneration of articular cartilage.
32027992	9	78	theme	properties	1505:1514	arg1	terms					1469:1473	terms	1469:1473	terms of composition and mechanical properties	1469:1514	In this attempt, the selection of a suitable biomaterial, in terms of composition and mechanical properties, is crucial.
32027992	6	79	theme	matrix	996:1001	arg1	deposition					1003:1012	specific matrix deposition	987:1012	specific matrix deposition	987:1012	HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation.
32027992	8	80	theme	osteochondral	1291:1303	arg1	disorders					1305:1313	osteochondral disorders	1291:1313	osteochondral disorders	1291:1313	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	11	81	theme	thermoplastic	1843:1855	arg1	PLA					1865:1867	thermoplastic polymer PLA	1843:1867	thermoplastic polymer PLA	1843:1867	Hybrid constructs prepared by co-printing this bioink and thermoplastic polymer PLA provided an optimal niche for chondrocyte growth and maintenance as well as mechanical properties necessary to support load forces exerted in native tissue.
32027992	0	82	theme	3D	89:90	arg1	bioprinting					92:102	3D bioprinting	89:102	3D bioprinting of articular cartilage engineering constructs	89:148	Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs.
32027992	11	83	theme	native	2011:2016	arg1	tissue					2018:2023	native tissue	2011:2023	native tissue	2011:2023	Hybrid constructs prepared by co-printing this bioink and thermoplastic polymer PLA provided an optimal niche for chondrocyte growth and maintenance as well as mechanical properties necessary to support load forces exerted in native tissue.
32027992	6	84	theme	gene	970:973	arg1	markers					975:981	chondrogenic gene markers	957:981	chondrogenic gene markers	957:981	HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation.
32027992	8	85	theme	tissue	1343:1348	arg1	constructs					1350:1359	cartilage tissue constructs	1333:1359	cartilage tissue constructs that restore and/or regenerate damaged tissue	1333:1405	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	10	86	theme	main	1612:1615	arg1	component					1617:1625	the main component	1608:1625	the main component of cartilage	1608:1638	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	10	86	theme	main	1612:1615	arg1	HA					1641:1642	HA	1641:1642	HA	1641:1642	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	7	87	theme	3D	1153:1154	arg1	bioprinting					1156:1166	3D bioprinting	1153:1166	3D bioprinting	1153:1166	These results indicate that it is a promising bioink candidate for cartilage tissue engineering based in 3D bioprinting.
32027992	5	88	theme	HA-based	806:813	arg1	bioink					815:820	HA-based bioink	806:820	HA-based bioink	806:820	To produce cartilage constructs with optimal mechanical properties, HA-based bioink was co-printed with polylactic acid (PLA).
32027992	6	89	theme	tissue	1030:1035	arg1	formation					1037:1045	tissue formation	1030:1045	tissue formation	1030:1045	HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation.
32027992	11	90	theme	polymer	1857:1863	arg1	PLA					1865:1867	thermoplastic polymer PLA	1843:1867	thermoplastic polymer PLA	1843:1867	Hybrid constructs prepared by co-printing this bioink and thermoplastic polymer PLA provided an optimal niche for chondrocyte growth and maintenance as well as mechanical properties necessary to support load forces exerted in native tissue.
32027992	7	91	theme	tissue	1125:1130	arg1	engineering					1132:1142	cartilage tissue engineering	1115:1142	cartilage tissue engineering based in 3D bioprinting	1115:1166	These results indicate that it is a promising bioink candidate for cartilage tissue engineering based in 3D bioprinting.
32027992	3	92	theme	tissue	587:592	arg1	bioprinting					597:607	cartilage tissue 3D bioprinting	577:607	cartilage tissue 3D bioprinting	577:607	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
32027992	8	93	theme	damaged	1392:1398	arg1	tissue					1400:1405	damaged tissue	1392:1405	damaged tissue	1392:1405	STATEMENT OF SIGNIFICANCE: The recent appearance of 3D printing technology has enabled great advances in the treatment of osteochondral disorders by fabrication of cartilage tissue constructs that restore and/or regenerate damaged tissue.
32027992	2	94	theme	viable	406:411	arg1	cartilage					413:421	viable cartilage substitutes	406:433	viable cartilage substitutes	406:433	The selection of a suitable bioink, in terms of composition and mechanical properties, is crucial for the development of viable cartilage substitutes.
32027992	5	95	theme	optimal	775:781	arg1	properties					794:803	optimal mechanical properties	775:803	optimal mechanical properties	775:803	To produce cartilage constructs with optimal mechanical properties, HA-based bioink was co-printed with polylactic acid (PLA).
32027992	9	96	from	terms	1469:1473	arg1	selection					1429:1437	the selection	1425:1437	the selection of a suitable biomaterial	1425:1463	In this attempt, the selection of a suitable biomaterial, in terms of composition and mechanical properties, is crucial.
32027992	9	96	from	terms	1469:1473	arg1	crucial					1520:1526	crucial	1520:1526	crucial	1520:1526	In this attempt, the selection of a suitable biomaterial, in terms of composition and mechanical properties, is crucial.
32027992	3	97	theme	main	487:490	arg1	components					502:511	the main cartilage components	483:511	the main cartilage components	483:511	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
32027992	10	98	theme	suitable	1650:1657	arg1	properties					1685:1694	suitable biological and mechanical properties	1650:1694	suitable biological and mechanical properties	1650:1694	In this study, we describe for first time the development of a bioink based on the main component of cartilage, HA, with suitable biological and mechanical properties, without involving toxic procedure, and its application in cartilage tissue bioprinting.
32027992	11	99	theme	co-printing	1815:1825	arg1	bioink					1832:1837	this bioink	1827:1837	this bioink	1827:1837	Hybrid constructs prepared by co-printing this bioink and thermoplastic polymer PLA provided an optimal niche for chondrocyte growth and maintenance as well as mechanical properties necessary to support load forces exerted in native tissue.
32027992	3	100	theme	components	502:511	arg1	one					476:478	one	476:478	one	476:478	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
32027992	3	100	theme	components	502:511	arg1	acid					525:528	hyaluronic acid	514:528	hyaluronic acid (HA)	514:533	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
32027992	3	100	theme	components	502:511	arg1	components					502:511	the main cartilage components	483:511	the main cartilage components	483:511	In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting.
33823344	0	0	theme	continuous	68:77	arg1	removal					79:85	continuous removal	68:85	continuous removal of copper(Cu2+) from wastewater	68:117	Fabrication of cylindrical 3D cellulose nanofibril(CNF) aerogel for continuous removal of copper(Cu2+) from wastewater.
33823344	1	1	theme	metal	126:130	arg1	problem					173:179	a serious problem	163:179	a serious problem due to its high toxicity	163:204	Heavy metal contamination in wastewater is a serious problem due to its high toxicity.
33823344	1	1	theme	metal	126:130	arg1	contamination					132:144	Heavy metal contamination	120:144	Heavy metal contamination in wastewater	120:158	Heavy metal contamination in wastewater is a serious problem due to its high toxicity.
33823344	5	2	theme	elastic	850:856	arg1	matrix					858:863	a durable elastic matrix	840:863	a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel	840:976	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	2	3	theme	@	320:320	arg1	aerogel					325:331	PEI@CNF aerogel	317:331	PEI@CNF aerogel	317:331	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	3	theme	@	320:320	arg1	aerogel					308:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel	222:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel)	222:332	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	6	4	theme	@	1015:1015	arg1	aerogel					1020:1026	the PEI@CNF aerogel	1008:1026	the PEI@CNF aerogel	1008:1026	Finally, in the column test, the PEI@CNF aerogel treats 88 bed volumes of wastewater containing Cu2+(∼20 mg/L).
33823344	7	5	theme	wastewater	1216:1225	arg1	Cu2+					1238:1241	wastewater containing Cu2+	1216:1241	wastewater containing Cu2+	1216:1241	This result demonstrates that PEI@CNF aerogels are practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+.
33823344	1	6	from	contamination	132:144	arg1	wastewater					149:158	wastewater	149:158	wastewater	149:158	Heavy metal contamination in wastewater is a serious problem due to its high toxicity.
33823344	2	7	theme	flexible	251:258	arg1	biosorbent					371:380	a highly efficient biosorbent	352:380	a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+)	352:444	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	7	theme	flexible	251:258	arg1	aerogel					325:331	PEI@CNF aerogel	317:331	PEI@CNF aerogel	317:331	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	7	theme	flexible	251:258	arg1	aerogel					308:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel	222:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel)	222:332	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	5	8	theme	excellent	890:898	arg1	stability					904:912	excellent wet stability	890:912	excellent wet stability	890:912	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	4	9	theme	nanofibrils	684:694	arg1	scaffold					703:710	the porous cellulose nanofibrils (CNFs) scaffold	663:710	the porous cellulose nanofibrils (CNFs) scaffold	663:710	The amine groups in polyethylene imine (PEI) grafted onto the porous cellulose nanofibrils (CNFs) scaffold form chelates with Cu2+ thereby effectively adsorbing Cu2+.
33823344	6	10	theme	Cu2+	1075:1078	arg1	volumes					1042:1048	88 bed volumes	1035:1048	88 bed volumes of wastewater containing Cu2+(∼20 mg/L)	1035:1088	Finally, in the column test, the PEI@CNF aerogel treats 88 bed volumes of wastewater containing Cu2+(∼20 mg/L).
33823344	7	11	theme	CNF	1125:1127	arg1	aerogels					1129:1136	PEI@CNF aerogels	1121:1136	PEI@CNF aerogels	1121:1136	This result demonstrates that PEI@CNF aerogels are practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+.
33823344	7	11	theme	CNF	1125:1127	arg1	bio-sorbents					1182:1193	practically viable and highly efficient bio-sorbents	1142:1193	practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+	1142:1241	This result demonstrates that PEI@CNF aerogels are practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+.
33823344	2	12	theme	CNF	321:323	arg1	aerogel					325:331	PEI@CNF aerogel	317:331	PEI@CNF aerogel	317:331	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	12	theme	CNF	321:323	arg1	aerogel					308:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel	222:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel)	222:332	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	3	13	theme	outstanding	535:545	arg1	selectivity					547:557	outstanding selectivity	535:557	outstanding selectivity for Cu2+	535:566	The synthesized PEI@CNF aerogel efficiently separates Cu2+ from wastewater and exhibits outstanding selectivity for Cu2+ in the presence of other metal ions.
33823344	5	14	theme	durable	842:848	arg1	matrix					858:863	a durable elastic matrix	840:863	a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel	840:976	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	6	15	theme	column	995:1000	arg1	test					1002:1005	the column test	991:1005	the column test	991:1005	Finally, in the column test, the PEI@CNF aerogel treats 88 bed volumes of wastewater containing Cu2+(∼20 mg/L).
33823344	2	16	theme	porous	240:245	arg1	biosorbent					371:380	a highly efficient biosorbent	352:380	a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+)	352:444	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	16	theme	porous	240:245	arg1	aerogel					325:331	PEI@CNF aerogel	317:331	PEI@CNF aerogel	317:331	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	16	theme	porous	240:245	arg1	aerogel					308:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel	222:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel)	222:332	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	5	17	theme	CNF	802:804	arg1	scaffold					806:813	a flexible CNF scaffold	791:813	a flexible CNF scaffold	791:813	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	0	18	theme	copper	90:95	arg1	removal					79:85	continuous removal	68:85	continuous removal of copper(Cu2+) from wastewater	68:117	Fabrication of cylindrical 3D cellulose nanofibril(CNF) aerogel for continuous removal of copper(Cu2+) from wastewater.
33823344	6	19	theme	bed	1038:1040	arg1	volumes					1042:1048	88 bed volumes	1035:1048	88 bed volumes of wastewater containing Cu2+(∼20 mg/L)	1035:1088	Finally, in the column test, the PEI@CNF aerogel treats 88 bed volumes of wastewater containing Cu2+(∼20 mg/L).
33823344	2	20	contain	containing	421:430	arg2	Cu2+					440:443	Cu2+	440:443	Cu2+	440:443	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	20	contain	containing	421:430	arg2	copper					432:437	copper	432:437	copper (Cu2+)	432:444	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	20	contain	containing	421:430	arg1	wastewater					410:419	wastewater	410:419	wastewater containing copper (Cu2+)	410:444	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	21	theme	three-dimensional	222:238	arg1	biosorbent					371:380	a highly efficient biosorbent	352:380	a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+)	352:444	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	21	theme	three-dimensional	222:238	arg1	aerogel					325:331	PEI@CNF aerogel	317:331	PEI@CNF aerogel	317:331	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	21	theme	three-dimensional	222:238	arg1	aerogel					308:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel	222:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel)	222:332	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	4	22	from	groups	615:620	arg1	PEI					645:647	PEI	645:647	PEI	645:647	The amine groups in polyethylene imine (PEI) grafted onto the porous cellulose nanofibrils (CNFs) scaffold form chelates with Cu2+ thereby effectively adsorbing Cu2+.
33823344	4	22	from	groups	615:620	arg1	imine					638:642	polyethylene imine	625:642	polyethylene imine (PEI) grafted onto the porous cellulose nanofibrils (CNFs) scaffold	625:710	The amine groups in polyethylene imine (PEI) grafted onto the porous cellulose nanofibrils (CNFs) scaffold form chelates with Cu2+ thereby effectively adsorbing Cu2+.
33823344	4	23	theme	amine	609:613	arg1	groups					615:620	The amine groups	605:620	The amine groups in polyethylene imine (PEI) grafted onto the porous cellulose nanofibrils (CNFs) scaffold	605:710	The amine groups in polyethylene imine (PEI) grafted onto the porous cellulose nanofibrils (CNFs) scaffold form chelates with Cu2+ thereby effectively adsorbing Cu2+.
33823344	2	24	theme	wastewater	410:419	arg1	treatment					397:405	continuous treatment	386:405	continuous treatment of wastewater containing copper (Cu2+)	386:444	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	25	theme	cellulose	287:295	arg1	biosorbent					371:380	a highly efficient biosorbent	352:380	a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+)	352:444	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	25	theme	cellulose	287:295	arg1	aerogel					325:331	PEI@CNF aerogel	317:331	PEI@CNF aerogel	317:331	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	25	theme	cellulose	287:295	arg1	aerogel					308:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel	222:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel)	222:332	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	7	26	theme	viable	1154:1159	arg1	aerogels					1129:1136	PEI@CNF aerogels	1121:1136	PEI@CNF aerogels	1121:1136	This result demonstrates that PEI@CNF aerogels are practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+.
33823344	7	26	theme	viable	1154:1159	arg1	bio-sorbents					1182:1193	practically viable and highly efficient bio-sorbents	1142:1193	practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+	1142:1241	This result demonstrates that PEI@CNF aerogels are practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+.
33823344	4	27	theme	polyethylene	625:636	arg1	PEI					645:647	PEI	645:647	PEI	645:647	The amine groups in polyethylene imine (PEI) grafted onto the porous cellulose nanofibrils (CNFs) scaffold form chelates with Cu2+ thereby effectively adsorbing Cu2+.
33823344	4	27	theme	polyethylene	625:636	arg1	imine					638:642	polyethylene imine	625:642	polyethylene imine (PEI) grafted onto the porous cellulose nanofibrils (CNFs) scaffold	625:710	The amine groups in polyethylene imine (PEI) grafted onto the porous cellulose nanofibrils (CNFs) scaffold form chelates with Cu2+ thereby effectively adsorbing Cu2+.
33823344	2	28	theme	grafted	279:285	arg1	biosorbent					371:380	a highly efficient biosorbent	352:380	a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+)	352:444	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	28	theme	grafted	279:285	arg1	aerogel					325:331	PEI@CNF aerogel	317:331	PEI@CNF aerogel	317:331	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	28	theme	grafted	279:285	arg1	aerogel					308:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel	222:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel)	222:332	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	5	29	theme	rigid	819:823	arg1	PEI					825:827	rigid PEI	819:827	rigid PEI	819:827	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	0	30	theme	3D	27:28	arg1	nanofibril					40:49	cylindrical 3D cellulose nanofibril	15:49	cylindrical 3D cellulose nanofibril(CNF)	15:54	Fabrication of cylindrical 3D cellulose nanofibril(CNF) aerogel for continuous removal of copper(Cu2+) from wastewater.
33823344	0	30	theme	3D	27:28	arg1	CNF					51:53	CNF	51:53	CNF	51:53	Fabrication of cylindrical 3D cellulose nanofibril(CNF) aerogel for continuous removal of copper(Cu2+) from wastewater.
33823344	4	31	theme	cellulose	674:682	arg1	scaffold					703:710	the porous cellulose nanofibrils (CNFs) scaffold	663:710	the porous cellulose nanofibrils (CNFs) scaffold	663:710	The amine groups in polyethylene imine (PEI) grafted onto the porous cellulose nanofibrils (CNFs) scaffold form chelates with Cu2+ thereby effectively adsorbing Cu2+.
33823344	2	32	theme	imine	273:277	arg1	biosorbent					371:380	a highly efficient biosorbent	352:380	a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+)	352:444	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	32	theme	imine	273:277	arg1	aerogel					325:331	PEI@CNF aerogel	317:331	PEI@CNF aerogel	317:331	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	32	theme	imine	273:277	arg1	aerogel					308:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel	222:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel)	222:332	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	1	33	theme	serious	165:171	arg1	problem					173:179	a serious problem	163:179	a serious problem due to its high toxicity	163:204	Heavy metal contamination in wastewater is a serious problem due to its high toxicity.
33823344	1	33	theme	serious	165:171	arg1	contamination					132:144	Heavy metal contamination	120:144	Heavy metal contamination in wastewater	120:158	Heavy metal contamination in wastewater is a serious problem due to its high toxicity.
33823344	0	34	theme	cylindrical	15:25	arg1	nanofibril					40:49	cylindrical 3D cellulose nanofibril	15:49	cylindrical 3D cellulose nanofibril(CNF)	15:54	Fabrication of cylindrical 3D cellulose nanofibril(CNF) aerogel for continuous removal of copper(Cu2+) from wastewater.
33823344	0	34	theme	cylindrical	15:25	arg1	CNF					51:53	CNF	51:53	CNF	51:53	Fabrication of cylindrical 3D cellulose nanofibril(CNF) aerogel for continuous removal of copper(Cu2+) from wastewater.
33823344	5	35	theme	aerogel	872:878	arg1	matrix					858:863	a durable elastic matrix	840:863	a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel	840:976	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	2	36	theme	polyethylene	260:271	arg1	biosorbent					371:380	a highly efficient biosorbent	352:380	a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+)	352:444	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	36	theme	polyethylene	260:271	arg1	aerogel					325:331	PEI@CNF aerogel	317:331	PEI@CNF aerogel	317:331	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	36	theme	polyethylene	260:271	arg1	aerogel					308:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel	222:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel)	222:332	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	5	37	theme	PEI	825:827	arg1	combination					776:786	The combination	772:786	The combination of a flexible CNF scaffold and rigid PEI	772:827	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	0	38	theme	nanofibril	40:49	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of cylindrical 3D cellulose nanofibril(CNF)	0:54	Fabrication of cylindrical 3D cellulose nanofibril(CNF) aerogel for continuous removal of copper(Cu2+) from wastewater.
33823344	5	39	theme	wet	900:902	arg1	stability					904:912	excellent wet stability	890:912	excellent wet stability	890:912	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	7	40	theme	efficient	1172:1180	arg1	aerogels					1129:1136	PEI@CNF aerogels	1121:1136	PEI@CNF aerogels	1121:1136	This result demonstrates that PEI@CNF aerogels are practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+.
33823344	7	40	theme	efficient	1172:1180	arg1	bio-sorbents					1182:1193	practically viable and highly efficient bio-sorbents	1142:1193	practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+	1142:1241	This result demonstrates that PEI@CNF aerogels are practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+.
33823344	2	41	theme	efficient	361:369	arg1	biosorbent					371:380	a highly efficient biosorbent	352:380	a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+)	352:444	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	41	theme	efficient	361:369	arg1	aerogel					308:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel	222:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel)	222:332	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	0	42	theme	cellulose	30:38	arg1	nanofibril					40:49	cylindrical 3D cellulose nanofibril	15:49	cylindrical 3D cellulose nanofibril(CNF)	15:54	Fabrication of cylindrical 3D cellulose nanofibril(CNF) aerogel for continuous removal of copper(Cu2+) from wastewater.
33823344	0	42	theme	cellulose	30:38	arg1	CNF					51:53	CNF	51:53	CNF	51:53	Fabrication of cylindrical 3D cellulose nanofibril(CNF) aerogel for continuous removal of copper(Cu2+) from wastewater.
33823344	6	43	theme	CNF	1016:1018	arg1	aerogel					1020:1026	the PEI@CNF aerogel	1008:1026	the PEI@CNF aerogel	1008:1026	Finally, in the column test, the PEI@CNF aerogel treats 88 bed volumes of wastewater containing Cu2+(∼20 mg/L).
33823344	3	44	theme	metal	593:597	arg1	ions					599:602	other metal ions	587:602	other metal ions	587:602	The synthesized PEI@CNF aerogel efficiently separates Cu2+ from wastewater and exhibits outstanding selectivity for Cu2+ in the presence of other metal ions.
33823344	4	45	theme	adsorbing	756:764	arg1	Cu2+					766:769	adsorbing Cu2+	756:769	Cu2+ thereby effectively adsorbing Cu2+	731:769	The amine groups in polyethylene imine (PEI) grafted onto the porous cellulose nanofibrils (CNFs) scaffold form chelates with Cu2+ thereby effectively adsorbing Cu2+.
33823344	5	46	theme	flexible	793:800	arg1	scaffold					806:813	a flexible CNF scaffold	791:813	a flexible CNF scaffold	791:813	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	3	47	theme	PEI	463:465	arg1	aerogel					471:477	The synthesized PEI@CNF aerogel	447:477	The synthesized PEI@CNF aerogel	447:477	The synthesized PEI@CNF aerogel efficiently separates Cu2+ from wastewater and exhibits outstanding selectivity for Cu2+ in the presence of other metal ions.
33823344	3	48	theme	ions	599:602	arg1	presence					575:582	the presence	571:582	the presence of other metal ions	571:602	The synthesized PEI@CNF aerogel efficiently separates Cu2+ from wastewater and exhibits outstanding selectivity for Cu2+ in the presence of other metal ions.
33823344	5	49	theme	PEI	962:964	arg1	aerogel					970:976	PEI@CNF aerogel	962:976	PEI@CNF aerogel	962:976	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	6	50	theme	PEI	1012:1014	arg1	aerogel					1020:1026	the PEI@CNF aerogel	1008:1026	the PEI@CNF aerogel	1008:1026	Finally, in the column test, the PEI@CNF aerogel treats 88 bed volumes of wastewater containing Cu2+(∼20 mg/L).
33823344	2	51	theme	PEI	317:319	arg1	aerogel					325:331	PEI@CNF aerogel	317:331	PEI@CNF aerogel	317:331	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	51	theme	PEI	317:319	arg1	aerogel					308:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel	222:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel)	222:332	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	5	52	theme	CNF	966:968	arg1	aerogel					970:976	PEI@CNF aerogel	962:976	PEI@CNF aerogel	962:976	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	5	53	theme	@	965:965	arg1	aerogel					970:976	PEI@CNF aerogel	962:976	PEI@CNF aerogel	962:976	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	3	54	theme	@	466:466	arg1	aerogel					471:477	The synthesized PEI@CNF aerogel	447:477	The synthesized PEI@CNF aerogel	447:477	The synthesized PEI@CNF aerogel efficiently separates Cu2+ from wastewater and exhibits outstanding selectivity for Cu2+ in the presence of other metal ions.
33823344	3	55	theme	synthesized	451:461	arg1	aerogel					471:477	The synthesized PEI@CNF aerogel	447:477	The synthesized PEI@CNF aerogel	447:477	The synthesized PEI@CNF aerogel efficiently separates Cu2+ from wastewater and exhibits outstanding selectivity for Cu2+ in the presence of other metal ions.
33823344	5	56	theme	recycle	943:949	arg1	ability					951:957	recycle ability	943:957	recycle ability	943:957	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	5	57	theme	aerogel	970:976	arg1	stability					904:912	excellent wet stability	890:912	excellent wet stability	890:912	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	5	57	theme	aerogel	970:976	arg1	property					930:937	shape recovery property	915:937	shape recovery property	915:937	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	5	57	theme	aerogel	970:976	arg1	ability					951:957	recycle ability	943:957	recycle ability	943:957	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	5	58	theme	recovery	921:928	arg1	property					930:937	shape recovery property	915:937	shape recovery property	915:937	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	7	59	theme	containing	1227:1236	arg1	Cu2+					1238:1241	wastewater containing Cu2+	1216:1241	wastewater containing Cu2+	1216:1241	This result demonstrates that PEI@CNF aerogels are practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+.
33823344	4	60	theme	porous	667:672	arg1	scaffold					703:710	the porous cellulose nanofibrils (CNFs) scaffold	663:710	the porous cellulose nanofibrils (CNFs) scaffold	663:710	The amine groups in polyethylene imine (PEI) grafted onto the porous cellulose nanofibrils (CNFs) scaffold form chelates with Cu2+ thereby effectively adsorbing Cu2+.
33823344	4	61	theme	CNFs	697:700	arg1	scaffold					703:710	the porous cellulose nanofibrils (CNFs) scaffold	663:710	the porous cellulose nanofibrils (CNFs) scaffold	663:710	The amine groups in polyethylene imine (PEI) grafted onto the porous cellulose nanofibrils (CNFs) scaffold form chelates with Cu2+ thereby effectively adsorbing Cu2+.
33823344	0	62	from	wastewater	108:117	arg1	removal					79:85	continuous removal	68:85	continuous removal of copper(Cu2+) from wastewater	68:117	Fabrication of cylindrical 3D cellulose nanofibril(CNF) aerogel for continuous removal of copper(Cu2+) from wastewater.
33823344	5	63	theme	shape	915:919	arg1	property					930:937	shape recovery property	915:937	shape recovery property	915:937	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	3	64	theme	other	587:591	arg1	ions					599:602	other metal ions	587:602	other metal ions	587:602	The synthesized PEI@CNF aerogel efficiently separates Cu2+ from wastewater and exhibits outstanding selectivity for Cu2+ in the presence of other metal ions.
33823344	6	65	theme	containing	1064:1073	arg1	∼20 mg/L					1080:1087	∼20 mg/L	1080:1087	∼20 mg/L	1080:1087	Finally, in the column test, the PEI@CNF aerogel treats 88 bed volumes of wastewater containing Cu2+(∼20 mg/L).
33823344	6	65	theme	containing	1064:1073	arg1	Cu2+					1075:1078	wastewater containing Cu2+	1053:1078	wastewater containing Cu2+(∼20 mg/L)	1053:1088	Finally, in the column test, the PEI@CNF aerogel treats 88 bed volumes of wastewater containing Cu2+(∼20 mg/L).
33823344	2	66	theme	nanofibril	297:306	arg1	biosorbent					371:380	a highly efficient biosorbent	352:380	a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+)	352:444	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	66	theme	nanofibril	297:306	arg1	aerogel					325:331	PEI@CNF aerogel	317:331	PEI@CNF aerogel	317:331	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	2	66	theme	nanofibril	297:306	arg1	aerogel					308:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel	222:314	three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel)	222:332	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	1	67	theme	high	192:195	arg1	toxicity					197:204	its high toxicity	188:204	its high toxicity	188:204	Heavy metal contamination in wastewater is a serious problem due to its high toxicity.
33823344	7	68	theme	Cu2+	1238:1241	arg1	treatment					1203:1211	the treatment	1199:1211	the treatment of wastewater containing Cu2+	1199:1241	This result demonstrates that PEI@CNF aerogels are practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+.
33823344	6	69	theme	wastewater	1053:1062	arg1	∼20 mg/L					1080:1087	∼20 mg/L	1080:1087	∼20 mg/L	1080:1087	Finally, in the column test, the PEI@CNF aerogel treats 88 bed volumes of wastewater containing Cu2+(∼20 mg/L).
33823344	6	69	theme	wastewater	1053:1062	arg1	Cu2+					1075:1078	wastewater containing Cu2+	1053:1078	wastewater containing Cu2+(∼20 mg/L)	1053:1088	Finally, in the column test, the PEI@CNF aerogel treats 88 bed volumes of wastewater containing Cu2+(∼20 mg/L).
33823344	3	70	theme	CNF	467:469	arg1	aerogel					471:477	The synthesized PEI@CNF aerogel	447:477	The synthesized PEI@CNF aerogel	447:477	The synthesized PEI@CNF aerogel efficiently separates Cu2+ from wastewater and exhibits outstanding selectivity for Cu2+ in the presence of other metal ions.
33823344	5	71	theme	scaffold	806:813	arg1	combination					776:786	The combination	772:786	The combination of a flexible CNF scaffold and rigid PEI	772:827	The combination of a flexible CNF scaffold and rigid PEI results in a durable elastic matrix of the aerogel providing excellent wet stability, shape recovery property and recycle ability of PEI@CNF aerogel.
33823344	7	72	theme	PEI	1121:1123	arg1	aerogels					1129:1136	PEI@CNF aerogels	1121:1136	PEI@CNF aerogels	1121:1136	This result demonstrates that PEI@CNF aerogels are practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+.
33823344	7	72	theme	PEI	1121:1123	arg1	bio-sorbents					1182:1193	practically viable and highly efficient bio-sorbents	1142:1193	practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+	1142:1241	This result demonstrates that PEI@CNF aerogels are practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+.
33823344	2	73	theme	continuous	386:395	arg1	treatment					397:405	continuous treatment	386:405	continuous treatment of wastewater containing copper (Cu2+)	386:444	In this study, three-dimensional porous and flexible polyethylene imine grafted cellulose nanofibril aerogel (PEI@CNF aerogel) is synthesized as a highly efficient biosorbent for continuous treatment of wastewater containing copper (Cu2+).
33823344	1	74	theme	Heavy	120:124	arg1	problem					173:179	a serious problem	163:179	a serious problem due to its high toxicity	163:204	Heavy metal contamination in wastewater is a serious problem due to its high toxicity.
33823344	1	74	theme	Heavy	120:124	arg1	contamination					132:144	Heavy metal contamination	120:144	Heavy metal contamination in wastewater	120:158	Heavy metal contamination in wastewater is a serious problem due to its high toxicity.
33823344	7	75	theme	@	1124:1124	arg1	aerogels					1129:1136	PEI@CNF aerogels	1121:1136	PEI@CNF aerogels	1121:1136	This result demonstrates that PEI@CNF aerogels are practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+.
33823344	7	75	theme	@	1124:1124	arg1	bio-sorbents					1182:1193	practically viable and highly efficient bio-sorbents	1142:1193	practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+	1142:1241	This result demonstrates that PEI@CNF aerogels are practically viable and highly efficient bio-sorbents for the treatment of wastewater containing Cu2+.
32043864	7	0	theme	absorbency	1707:1716	arg1	g-1					1743:1745	60.2 g g-1	1736:1745	60.2 g g-1	1736:1745	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	7	0	theme	absorbency	1707:1716	arg1	efficiency					1718:1727	oil absorbency efficiency	1703:1727	oil absorbency efficiency (e.g., 60.2 g g-1)	1703:1746	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	8	1	theme	coassembly	1864:1873	arg1	strategy					1875:1882	This coassembly strategy	1859:1882	This coassembly strategy	1859:1882	This coassembly strategy offers the opportunities for the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings.
32043864	8	2	theme	materials	1938:1946	arg1	design					1917:1922	the design	1913:1922	the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings	1913:2092	This coassembly strategy offers the opportunities for the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings.
32043864	1	3	theme	huge	311:314	arg1	challenge					316:324	a huge challenge	309:324	a huge challenge	309:324	Creating a configurable and controllable surface for structure-integrated multifunctionality of ultralight aerogels is of significance but remains a huge challenge because of the critical limitations of mechanical vulnerability and structural processability.
32043864	8	4	from	demands	2021:2027	arg1	fields					2037:2042	many fields	2032:2042	many fields	2032:2042	This coassembly strategy offers the opportunities for the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings.
32043864	3	5	theme	structural	848:857	arg1	vulnerability					859:871	structural vulnerability	848:871	structural vulnerability	848:871	The in situ superimposed construction of bioinspired topography and intrinsic topology is for the first time performed for programmable binary architectures with multifunctionality without engendering structural vulnerability and functional disruption.
32043864	8	6	theme	topography-	1953:1963	arg1	features					1989:1996	topography- and function-tailorable features	1953:1996	topography- and function-tailorable features	1953:1996	This coassembly strategy offers the opportunities for the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings.
32043864	1	7	theme	controllable	190:201	arg1	surface					203:209	a configurable and controllable surface	171:209	a configurable and controllable surface for structure-integrated multifunctionality of ultralight aerogels	171:276	Creating a configurable and controllable surface for structure-integrated multifunctionality of ultralight aerogels is of significance but remains a huge challenge because of the critical limitations of mechanical vulnerability and structural processability.
32043864	7	8	theme	anti-icing	1680:1689	arg1	properties					1691:1700	anti-icing properties	1680:1700	anti-icing properties	1680:1700	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	5	9	dep	unity	1196:1200	arg1	the					1181:1183	the	1181:1183	the	1181:1183	The self-generated bioinspired surface with f-NC greatly maintains the structural unity and mechanical robustness, which enable self-adaptability and self-supporting of surface configurations.
32043864	8	10	theme	function-tailorable	1969:1987	arg1	features					1989:1996	topography- and function-tailorable features	1953:1996	topography- and function-tailorable features	1953:1996	This coassembly strategy offers the opportunities for the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings.
32043864	0	11	theme	Thermal	127:133	arg1	Insulation					135:144	Thermal Insulation	127:144	Thermal Insulation via Coassembly	127:159	Ultralight Programmable Bioinspired Aerogels with an Integrated Multifunctional Surface for Self-Cleaning, Oil Absorption, and Thermal Insulation via Coassembly.
32043864	7	12	dep	compress-recovery	1609:1625	arg1	e.g.					1580:1583	e.g.	1580:1583	e.g.	1580:1583	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	4	13	theme	multitasking	1095:1106	arg1	role					1108:1111	a multitasking role	1093:1111	a multitasking role	1093:1111	By introducing the binding groups for hydrophobicity tailoring, functionalized nanocellulose (f-NC) is prepared via mechanochemistry as a structural, functional, and topographical modifier for a multitasking role.
32043864	1	14	theme	ultralight	258:267	arg1	aerogels					269:276	ultralight aerogels	258:276	ultralight aerogels	258:276	Creating a configurable and controllable surface for structure-integrated multifunctionality of ultralight aerogels is of significance but remains a huge challenge because of the critical limitations of mechanical vulnerability and structural processability.
32043864	7	15	theme	overall	1838:1844	arg1	performance					1846:1856	the overall performance	1834:1856	the overall performance	1834:1856	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	5	16	with	surface	1145:1151	arg1	f-NC					1158:1161	f-NC	1158:1161	f-NC	1158:1161	The self-generated bioinspired surface with f-NC greatly maintains the structural unity and mechanical robustness, which enable self-adaptability and self-supporting of surface configurations.
32043864	3	17	theme	bioinspired	688:698	arg1	topography					700:709	bioinspired topography	688:709	bioinspired topography	688:709	The in situ superimposed construction of bioinspired topography and intrinsic topology is for the first time performed for programmable binary architectures with multifunctionality without engendering structural vulnerability and functional disruption.
32043864	4	18	theme	topographical	1066:1078	arg1	nanocellulose					979:991	functionalized nanocellulose	964:991	functionalized nanocellulose (f-NC)	964:998	By introducing the binding groups for hydrophobicity tailoring, functionalized nanocellulose (f-NC) is prepared via mechanochemistry as a structural, functional, and topographical modifier for a multitasking role.
32043864	4	18	theme	topographical	1066:1078	arg1	modifier					1080:1087	a structural, functional, and topographical modifier	1036:1087	a structural, functional, and topographical modifier for a multitasking role	1036:1111	By introducing the binding groups for hydrophobicity tailoring, functionalized nanocellulose (f-NC) is prepared via mechanochemistry as a structural, functional, and topographical modifier for a multitasking role.
32043864	6	19	theme	structure-adaptable	1410:1428	arg1	multifunctionalities					1430:1449	structure-adaptable multifunctionalities	1410:1449	structure-adaptable multifunctionalities	1410:1449	With fine-tuning of nucleation-driving, the binary microstructures can be controllably diversified for structure-adaptable multifunctionalities.
32043864	8	20	theme	many	2032:2035	arg1	fields					2037:2042	many fields	2032:2042	many fields	2032:2042	This coassembly strategy offers the opportunities for the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings.
32043864	7	21	theme	high-temperature	1592:1607	arg1	compress-recovery					1609:1625	90.7% high-temperature compress-recovery	1586:1625	90.7% high-temperature compress-recovery	1586:1625	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	1	22	theme	vulnerability	376:388	arg1	limitations					350:360	the critical limitations	337:360	the critical limitations of mechanical vulnerability and structural processability	337:418	Creating a configurable and controllable surface for structure-integrated multifunctionality of ultralight aerogels is of significance but remains a huge challenge because of the critical limitations of mechanical vulnerability and structural processability.
32043864	3	23	theme	topology	725:732	arg1	construction					672:683	The in situ superimposed construction	647:683	The in situ superimposed construction of bioinspired topography and intrinsic topology	647:732	The in situ superimposed construction of bioinspired topography and intrinsic topology is for the first time performed for programmable binary architectures with multifunctionality without engendering structural vulnerability and functional disruption.
32043864	7	24	theme	S.	1477:1478	arg1	g					1518:1518	0.054 g cm-3	1512:1523	0.054 g cm-3	1512:1523	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	7	24	theme	S.	1477:1478	arg1	aerogels					1496:1503	The resulting ultralight S. minima-inspired aerogels	1452:1503	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3)	1452:1524	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	1	25	theme	structural	394:403	arg1	processability					405:418	structural processability	394:418	structural processability	394:418	Creating a configurable and controllable surface for structure-integrated multifunctionality of ultralight aerogels is of significance but remains a huge challenge because of the critical limitations of mechanical vulnerability and structural processability.
32043864	8	26	theme	smart	2052:2056	arg1	surfaces					2058:2065	smart surfaces	2052:2065	smart surfaces	2052:2065	This coassembly strategy offers the opportunities for the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings.
32043864	1	27	theme	configurable	173:184	arg1	surface					203:209	a configurable and controllable surface	171:209	a configurable and controllable surface for structure-integrated multifunctionality of ultralight aerogels	171:276	Creating a configurable and controllable surface for structure-integrated multifunctionality of ultralight aerogels is of significance but remains a huge challenge because of the critical limitations of mechanical vulnerability and structural processability.
32043864	2	28	theme	function-adaptable	602:619	arg1	surfaces					621:628	function-adaptable surfaces	602:628	function-adaptable surfaces	602:628	Herein, inspired by Salvinia minima, the facile and one-step coassembly approach is developed to allow the structured aerogels to spontaneously replicate Salvinia-like textures for function-adaptable surfaces morphologically.
32043864	8	29	with	materials	1938:1946	arg1	features					1989:1996	topography- and function-tailorable features	1953:1996	topography- and function-tailorable features	1953:1996	This coassembly strategy offers the opportunities for the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings.
32043864	4	30	theme	binding	919:925	arg1	groups					927:932	the binding groups	915:932	the binding groups for hydrophobicity tailoring	915:961	By introducing the binding groups for hydrophobicity tailoring, functionalized nanocellulose (f-NC) is prepared via mechanochemistry as a structural, functional, and topographical modifier for a multitasking role.
32043864	0	31	theme	Oil	107:109	arg1	Absorption					111:120	Oil Absorption	107:120	Oil Absorption	107:120	Ultralight Programmable Bioinspired Aerogels with an Integrated Multifunctional Surface for Self-Cleaning, Oil Absorption, and Thermal Insulation via Coassembly.
32043864	5	32	theme	configurations	1291:1304	arg1	self-supporting					1264:1278	self-supporting	1264:1278	self-supporting	1264:1278	The self-generated bioinspired surface with f-NC greatly maintains the structural unity and mechanical robustness, which enable self-adaptability and self-supporting of surface configurations.
32043864	5	32	theme	configurations	1291:1304	arg1	self-adaptability					1242:1258	self-adaptability	1242:1258	self-adaptability	1242:1258	The self-generated bioinspired surface with f-NC greatly maintains the structural unity and mechanical robustness, which enable self-adaptability and self-supporting of surface configurations.
32043864	7	33	dep	presented	1526:1534	arg1	superior					1804:1811	superior	1804:1811	superior	1804:1811	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	7	34	theme	%	1590:1590	arg1	compress-recovery					1609:1625	90.7% high-temperature compress-recovery	1586:1625	90.7% high-temperature compress-recovery	1586:1625	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	2	35	theme	Salvinia	441:448	arg1	minima					450:455	Salvinia minima	441:455	Salvinia minima	441:455	Herein, inspired by Salvinia minima, the facile and one-step coassembly approach is developed to allow the structured aerogels to spontaneously replicate Salvinia-like textures for function-adaptable surfaces morphologically.
32043864	2	36	theme	one-step	473:480	arg1	approach					493:500	the facile and one-step coassembly approach	458:500	the facile and one-step coassembly approach	458:500	Herein, inspired by Salvinia minima, the facile and one-step coassembly approach is developed to allow the structured aerogels to spontaneously replicate Salvinia-like textures for function-adaptable surfaces morphologically.
32043864	5	37	theme	self-generated	1118:1131	arg1	surface					1145:1151	The self-generated bioinspired surface	1114:1151	The self-generated bioinspired surface with f-NC	1114:1161	The self-generated bioinspired surface with f-NC greatly maintains the structural unity and mechanical robustness, which enable self-adaptability and self-supporting of surface configurations.
32043864	2	38	theme	structured	528:537	arg1	aerogels					539:546	the structured aerogels	524:546	the structured aerogels	524:546	Herein, inspired by Salvinia minima, the facile and one-step coassembly approach is developed to allow the structured aerogels to spontaneously replicate Salvinia-like textures for function-adaptable surfaces morphologically.
32043864	2	39	theme	facile	462:467	arg1	approach					493:500	the facile and one-step coassembly approach	458:500	the facile and one-step coassembly approach	458:500	Herein, inspired by Salvinia minima, the facile and one-step coassembly approach is developed to allow the structured aerogels to spontaneously replicate Salvinia-like textures for function-adaptable surfaces morphologically.
32043864	1	40	theme	critical	341:348	arg1	limitations					350:360	the critical limitations	337:360	the critical limitations of mechanical vulnerability and structural processability	337:418	Creating a configurable and controllable surface for structure-integrated multifunctionality of ultralight aerogels is of significance but remains a huge challenge because of the critical limitations of mechanical vulnerability and structural processability.
32043864	7	41	theme	temperature-endured	1548:1566	arg1	elasticity					1568:1577	outstanding temperature-endured elasticity	1536:1577	outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles)	1536:1648	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	3	42	theme	first	745:749	arg1	time					751:754	the first time	741:754	the first time performed for programmable binary architectures with multifunctionality	741:826	The in situ superimposed construction of bioinspired topography and intrinsic topology is for the first time performed for programmable binary architectures with multifunctionality without engendering structural vulnerability and functional disruption.
32043864	0	43	theme	Integrated	53:62	arg1	Surface					80:86	an Integrated Multifunctional Surface	50:86	an Integrated Multifunctional Surface for Self-Cleaning, Oil Absorption, and Thermal Insulation via Coassembly	50:159	Ultralight Programmable Bioinspired Aerogels with an Integrated Multifunctional Surface for Self-Cleaning, Oil Absorption, and Thermal Insulation via Coassembly.
32043864	1	44	theme	aerogels	269:276	arg1	multifunctionality					236:253	structure-integrated multifunctionality	215:253	structure-integrated multifunctionality of ultralight aerogels	215:276	Creating a configurable and controllable surface for structure-integrated multifunctionality of ultralight aerogels is of significance but remains a huge challenge because of the critical limitations of mechanical vulnerability and structural processability.
32043864	3	45	theme	programmable	770:781	arg1	architectures					790:802	programmable binary architectures	770:802	programmable binary architectures with multifunctionality	770:826	The in situ superimposed construction of bioinspired topography and intrinsic topology is for the first time performed for programmable binary architectures with multifunctionality without engendering structural vulnerability and functional disruption.
32043864	4	46	theme	functionalized	964:977	arg1	f-NC					994:997	f-NC	994:997	f-NC	994:997	By introducing the binding groups for hydrophobicity tailoring, functionalized nanocellulose (f-NC) is prepared via mechanochemistry as a structural, functional, and topographical modifier for a multitasking role.
32043864	4	46	theme	functionalized	964:977	arg1	modifier					1080:1087	a structural, functional, and topographical modifier	1036:1087	a structural, functional, and topographical modifier for a multitasking role	1036:1111	By introducing the binding groups for hydrophobicity tailoring, functionalized nanocellulose (f-NC) is prepared via mechanochemistry as a structural, functional, and topographical modifier for a multitasking role.
32043864	4	46	theme	functionalized	964:977	arg1	nanocellulose					979:991	functionalized nanocellulose	964:991	functionalized nanocellulose (f-NC)	964:998	By introducing the binding groups for hydrophobicity tailoring, functionalized nanocellulose (f-NC) is prepared via mechanochemistry as a structural, functional, and topographical modifier for a multitasking role.
32043864	5	47	theme	structural	1185:1194	arg1	unity					1196:1200	structural unity	1185:1200	structural unity	1185:1200	The self-generated bioinspired surface with f-NC greatly maintains the structural unity and mechanical robustness, which enable self-adaptability and self-supporting of surface configurations.
32043864	7	48	theme	g	1741:1741	arg1	g-1					1743:1745	60.2 g g-1	1736:1745	60.2 g g-1	1736:1745	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	7	48	theme	g	1741:1741	arg1	efficiency					1718:1727	oil absorbency efficiency	1703:1727	oil absorbency efficiency (e.g., 60.2 g g-1)	1703:1746	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	4	49	theme	structural	1038:1047	arg1	nanocellulose					979:991	functionalized nanocellulose	964:991	functionalized nanocellulose (f-NC)	964:998	By introducing the binding groups for hydrophobicity tailoring, functionalized nanocellulose (f-NC) is prepared via mechanochemistry as a structural, functional, and topographical modifier for a multitasking role.
32043864	4	49	theme	structural	1038:1047	arg1	modifier					1080:1087	a structural, functional, and topographical modifier	1036:1087	a structural, functional, and topographical modifier for a multitasking role	1036:1111	By introducing the binding groups for hydrophobicity tailoring, functionalized nanocellulose (f-NC) is prepared via mechanochemistry as a structural, functional, and topographical modifier for a multitasking role.
32043864	3	50	theme	functional	877:886	arg1	disruption					888:897	functional disruption	877:897	functional disruption	877:897	The in situ superimposed construction of bioinspired topography and intrinsic topology is for the first time performed for programmable binary architectures with multifunctionality without engendering structural vulnerability and functional disruption.
32043864	8	51	theme	ultralight	1927:1936	arg1	materials					1938:1946	ultralight materials	1927:1946	ultralight materials with topography- and function-tailorable features	1927:1996	This coassembly strategy offers the opportunities for the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings.
32043864	7	52	theme	oil	1703:1705	arg1	g-1					1743:1745	60.2 g g-1	1736:1745	60.2 g g-1	1736:1745	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	7	52	theme	oil	1703:1705	arg1	efficiency					1718:1727	oil absorbency efficiency	1703:1727	oil absorbency efficiency (e.g., 60.2 g g-1)	1703:1746	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	3	53	theme	superimposed	659:670	arg1	construction					672:683	The in situ superimposed construction	647:683	The in situ superimposed construction of bioinspired topography and intrinsic topology	647:732	The in situ superimposed construction of bioinspired topography and intrinsic topology is for the first time performed for programmable binary architectures with multifunctionality without engendering structural vulnerability and functional disruption.
32043864	3	54	with	architectures	790:802	arg1	multifunctionality					809:826	multifunctionality	809:826	multifunctionality	809:826	The in situ superimposed construction of bioinspired topography and intrinsic topology is for the first time performed for programmable binary architectures with multifunctionality without engendering structural vulnerability and functional disruption.
32043864	6	55	with	diversified	1394:1404	arg1	fine-tuning					1312:1322	fine-tuning	1312:1322	fine-tuning of nucleation-driving	1312:1344	With fine-tuning of nucleation-driving, the binary microstructures can be controllably diversified for structure-adaptable multifunctionalities.
32043864	3	56	theme	in	651:652	arg1	construction					672:683	The in situ superimposed construction	647:683	The in situ superimposed construction of bioinspired topography and intrinsic topology	647:732	The in situ superimposed construction of bioinspired topography and intrinsic topology is for the first time performed for programmable binary architectures with multifunctionality without engendering structural vulnerability and functional disruption.
32043864	5	57	theme	bioinspired	1133:1143	arg1	surface					1145:1151	The self-generated bioinspired surface	1114:1151	The self-generated bioinspired surface with f-NC	1114:1161	The self-generated bioinspired surface with f-NC greatly maintains the structural unity and mechanical robustness, which enable self-adaptability and self-supporting of surface configurations.
32043864	6	58	theme	binary	1351:1356	arg1	diversified					1394:1404	diversified	1394:1404	diversified	1394:1404	With fine-tuning of nucleation-driving, the binary microstructures can be controllably diversified for structure-adaptable multifunctionalities.
32043864	6	58	theme	binary	1351:1356	arg1	microstructures					1358:1372	the binary microstructures	1347:1372	the binary microstructures	1347:1372	With fine-tuning of nucleation-driving, the binary microstructures can be controllably diversified for structure-adaptable multifunctionalities.
32043864	3	59	theme	topography	700:709	arg1	construction					672:683	The in situ superimposed construction	647:683	The in situ superimposed construction of bioinspired topography and intrinsic topology	647:732	The in situ superimposed construction of bioinspired topography and intrinsic topology is for the first time performed for programmable binary architectures with multifunctionality without engendering structural vulnerability and functional disruption.
32043864	7	60	theme	durable	1651:1657	arg1	superhydrophobicity					1659:1677	durable superhydrophobicity	1651:1677	durable superhydrophobicity	1651:1677	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	5	61	theme	surface	1283:1289	arg1	configurations					1291:1304	surface configurations	1283:1304	surface configurations	1283:1304	The self-generated bioinspired surface with f-NC greatly maintains the structural unity and mechanical robustness, which enable self-adaptability and self-supporting of surface configurations.
32043864	4	62	theme	functional	1050:1059	arg1	nanocellulose					979:991	functionalized nanocellulose	964:991	functionalized nanocellulose (f-NC)	964:998	By introducing the binding groups for hydrophobicity tailoring, functionalized nanocellulose (f-NC) is prepared via mechanochemistry as a structural, functional, and topographical modifier for a multitasking role.
32043864	4	62	theme	functional	1050:1059	arg1	modifier					1080:1087	a structural, functional, and topographical modifier	1036:1087	a structural, functional, and topographical modifier for a multitasking role	1036:1111	By introducing the binding groups for hydrophobicity tailoring, functionalized nanocellulose (f-NC) is prepared via mechanochemistry as a structural, functional, and topographical modifier for a multitasking role.
32043864	8	63	theme	increasing	2010:2019	arg1	surfaces					2058:2065	smart surfaces	2052:2065	smart surfaces	2052:2065	This coassembly strategy offers the opportunities for the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings.
32043864	8	63	theme	increasing	2010:2019	arg1	coatings					2085:2092	self-cleaning coatings	2071:2092	self-cleaning coatings	2071:2092	This coassembly strategy offers the opportunities for the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings.
32043864	8	63	theme	increasing	2010:2019	arg1	demands					2021:2027	the increasing demands	2006:2027	the increasing demands in many fields such as smart surfaces and self-cleaning coatings	2006:2092	This coassembly strategy offers the opportunities for the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings.
32043864	7	64	theme	multiple	1633:1640	arg1	cycles					1642:1647	multiple cycles	1633:1647	multiple cycles	1633:1647	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	7	65	theme	minima-inspired	1480:1494	arg1	g					1518:1518	0.054 g cm-3	1512:1523	0.054 g cm-3	1512:1523	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	7	65	theme	minima-inspired	1480:1494	arg1	aerogels					1496:1503	The resulting ultralight S. minima-inspired aerogels	1452:1503	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3)	1452:1524	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	3	66	theme	intrinsic	715:723	arg1	topology					725:732	intrinsic topology	715:732	intrinsic topology	715:732	The in situ superimposed construction of bioinspired topography and intrinsic topology is for the first time performed for programmable binary architectures with multifunctionality without engendering structural vulnerability and functional disruption.
32043864	1	67	theme	structure-integrated	215:234	arg1	multifunctionality					236:253	structure-integrated multifunctionality	215:253	structure-integrated multifunctionality of ultralight aerogels	215:276	Creating a configurable and controllable surface for structure-integrated multifunctionality of ultralight aerogels is of significance but remains a huge challenge because of the critical limitations of mechanical vulnerability and structural processability.
32043864	3	68	dep	in	651:652	arg1	situ					654:657	situ	654:657	situ	654:657	The in situ superimposed construction of bioinspired topography and intrinsic topology is for the first time performed for programmable binary architectures with multifunctionality without engendering structural vulnerability and functional disruption.
32043864	7	69	theme	resulting	1456:1464	arg1	g					1518:1518	0.054 g cm-3	1512:1523	0.054 g cm-3	1512:1523	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	7	69	theme	resulting	1456:1464	arg1	aerogels					1496:1503	The resulting ultralight S. minima-inspired aerogels	1452:1503	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3)	1452:1524	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	1	70	theme	processability	405:418	arg1	limitations					350:360	the critical limitations	337:360	the critical limitations of mechanical vulnerability and structural processability	337:418	Creating a configurable and controllable surface for structure-integrated multifunctionality of ultralight aerogels is of significance but remains a huge challenge because of the critical limitations of mechanical vulnerability and structural processability.
32043864	7	71	dep	g	1518:1518	arg1	e.g.					1506:1509	e.g.	1506:1509	e.g.	1506:1509	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	7	72	theme	90.7	1586:1589	arg1	%					1590:1590	%	1590:1590	%	1590:1590	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	2	73	theme	Salvinia-like	575:587	arg1	textures					589:596	Salvinia-like textures	575:596	Salvinia-like textures for function-adaptable surfaces	575:628	Herein, inspired by Salvinia minima, the facile and one-step coassembly approach is developed to allow the structured aerogels to spontaneously replicate Salvinia-like textures for function-adaptable surfaces morphologically.
32043864	8	74	theme	self-cleaning	2071:2083	arg1	coatings					2085:2092	self-cleaning coatings	2071:2092	self-cleaning coatings	2071:2092	This coassembly strategy offers the opportunities for the design of ultralight materials with topography- and function-tailorable features to meet the increasing demands in many fields such as smart surfaces and self-cleaning coatings.
32043864	7	75	dep	g-1	1743:1745	arg1	e.g.					1730:1733	e.g.	1730:1733	e.g.	1730:1733	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	2	76	theme	coassembly	482:491	arg1	approach					493:500	the facile and one-step coassembly approach	458:500	the facile and one-step coassembly approach	458:500	Herein, inspired by Salvinia minima, the facile and one-step coassembly approach is developed to allow the structured aerogels to spontaneously replicate Salvinia-like textures for function-adaptable surfaces morphologically.
32043864	7	77	theme	outstanding	1536:1546	arg1	elasticity					1568:1577	outstanding temperature-endured elasticity	1536:1577	outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles)	1536:1648	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	0	78	theme	Multifunctional	64:78	arg1	Surface					80:86	an Integrated Multifunctional Surface	50:86	an Integrated Multifunctional Surface for Self-Cleaning, Oil Absorption, and Thermal Insulation via Coassembly	50:159	Ultralight Programmable Bioinspired Aerogels with an Integrated Multifunctional Surface for Self-Cleaning, Oil Absorption, and Thermal Insulation via Coassembly.
32043864	5	79	theme	mechanical	1206:1215	arg1	robustness					1217:1226	mechanical robustness	1206:1226	mechanical robustness	1206:1226	The self-generated bioinspired surface with f-NC greatly maintains the structural unity and mechanical robustness, which enable self-adaptability and self-supporting of surface configurations.
32043864	3	80	theme	binary	783:788	arg1	architectures					790:802	programmable binary architectures	770:802	programmable binary architectures with multifunctionality	770:826	The in situ superimposed construction of bioinspired topography and intrinsic topology is for the first time performed for programmable binary architectures with multifunctionality without engendering structural vulnerability and functional disruption.
32043864	1	81	theme	mechanical	365:374	arg1	vulnerability					376:388	mechanical vulnerability	365:388	mechanical vulnerability	365:388	Creating a configurable and controllable surface for structure-integrated multifunctionality of ultralight aerogels is of significance but remains a huge challenge because of the critical limitations of mechanical vulnerability and structural processability.
32043864	6	82	theme	nucleation-driving	1327:1344	arg1	fine-tuning					1312:1322	fine-tuning	1312:1322	fine-tuning of nucleation-driving	1312:1344	With fine-tuning of nucleation-driving, the binary microstructures can be controllably diversified for structure-adaptable multifunctionalities.
32043864	4	83	theme	hydrophobicity	938:951	arg1	tailoring					953:961	hydrophobicity tailoring	938:961	hydrophobicity tailoring	938:961	By introducing the binding groups for hydrophobicity tailoring, functionalized nanocellulose (f-NC) is prepared via mechanochemistry as a structural, functional, and topographical modifier for a multitasking role.
32043864	7	84	theme	thermal	1753:1759	arg1	insulating					1761:1770	thermal insulating	1753:1770	thermal insulating (e.g., 0.075 W mK-1)	1753:1791	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	7	84	theme	thermal	1753:1759	arg1	W					1785:1785	0.075 W mK-1	1779:1790	0.075 W mK-1	1779:1790	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32043864	7	85	dep	W	1785:1785	arg1	e.g.					1773:1776	e.g.	1773:1776	e.g.	1773:1776	The resulting ultralight S. minima-inspired aerogels (e.g., 0.054 g cm-3) presented outstanding temperature-endured elasticity (e.g., 90.7% high-temperature compress-recovery after multiple cycles), durable superhydrophobicity, anti-icing properties, oil absorbency efficiency (e.g., 60.2 g g-1), and thermal insulating (e.g., 0.075 W mK-1), which are superior to these reported on the overall performance.
32653371	9	0	theme	growth	1191:1196	arg1	factor					1198:1203	fibroblast growth factor 1	1180:1205	fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2	1180:1254	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	9	0	theme	growth	1191:1196	arg1	FGF1					1208:1211	FGF1	1208:1211	FGF1	1208:1211	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	6	1	from	24 h	778:781	arg1	values					759:764	IC50 values	754:764	IC50 values at 12 h and 24 h	754:781	IC50 values at 12 h and 24 h were 2.70 mg/mL and 2.85 mg/mL, respectively.
32653371	7	2	theme	Western	829:835	arg1	blotting					837:844	Western blotting	829:844	Western blotting	829:844	Western blotting showed that TSC2 was up-regulated at an LAO concentration of 3.80 mg/mL.
32653371	1	3	theme	storage	135:141	arg1	glucan					143:148	a storage glucan	133:148	a storage glucan	133:148	Laminarin (LA), a storage glucan, was purified from the brown alga Sargassum thunbergii.
32653371	1	3	theme	storage	135:141	arg1	Laminarin					117:125	Laminarin	117:125	Laminarin (LA)	117:130	Laminarin (LA), a storage glucan, was purified from the brown alga Sargassum thunbergii.
32653371	0	4	theme	anti-lung	90:98	arg1	activity					107:114	its anti-lung cancer activity	86:114	its anti-lung cancer activity	86:114	Structural analysis of a glucoglucuronan derived from laminarin and the mechanisms of its anti-lung cancer activity.
32653371	9	5	theme	Surface	1056:1062	arg1	SPR					1083:1085	SPR	1083:1085	SPR	1083:1085	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	9	5	theme	Surface	1056:1062	arg1	resonance					1072:1080	Surface plasmon resonance	1056:1080	Surface plasmon resonance (SPR) studies	1056:1094	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	4	6	theme	-linked	634:640	arg1	β-D-Glcp					642:649	-linked β-D-Glcp	634:649	-linked β-D-Glcp	634:649	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
32653371	9	7	theme	heparin	1169:1175	arg1	binding					1158:1164	the binding	1154:1164	the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2	1154:1254	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	9	8	theme	plasmon	1064:1070	arg1	SPR					1083:1085	SPR	1083:1085	SPR	1083:1085	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	9	8	theme	plasmon	1064:1070	arg1	resonance					1072:1080	Surface plasmon resonance	1056:1080	Surface plasmon resonance (SPR) studies	1056:1094	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	5	9	theme	cancer	713:718	arg1	proliferation					730:742	human lung cancer A549 cell proliferation	702:742	human lung cancer A549 cell proliferation	702:742	LAO inhibited human lung cancer A549 cell proliferation in vitro.
32653371	0	10	theme	activity	107:114	arg1	mechanisms					72:81	the mechanisms	68:81	the mechanisms of its anti-lung cancer activity	68:114	Structural analysis of a glucoglucuronan derived from laminarin and the mechanisms of its anti-lung cancer activity.
32653371	0	10	theme	activity	107:114	arg1	laminarin					54:62	laminarin	54:62	laminarin	54:62	Structural analysis of a glucoglucuronan derived from laminarin and the mechanisms of its anti-lung cancer activity.
32653371	9	11	theme	A549	1317:1320	arg1	proliferation					1327:1339	A549 cell proliferation	1317:1339	A549 cell proliferation	1317:1339	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	5	12	theme	lung	708:711	arg1	proliferation					730:742	human lung cancer A549 cell proliferation	702:742	human lung cancer A549 cell proliferation	702:742	LAO inhibited human lung cancer A549 cell proliferation in vitro.
32653371	2	13	theme	nitroxyl	248:255	arg1	radical					257:263	the stable nitroxyl radical	237:263	the stable nitroxyl radical	237:263	After specific oxidation using the stable nitroxyl radical, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), together with NaBr and NaClO, glucoglucuronan (LAO) was obtained.
32653371	5	14	theme	cell	725:728	arg1	proliferation					730:742	human lung cancer A549 cell proliferation	702:742	human lung cancer A549 cell proliferation	702:742	LAO inhibited human lung cancer A549 cell proliferation in vitro.
32653371	0	15	theme	cancer	100:105	arg1	activity					107:114	its anti-lung cancer activity	86:114	its anti-lung cancer activity	86:114	Structural analysis of a glucoglucuronan derived from laminarin and the mechanisms of its anti-lung cancer activity.
32653371	6	16	theme	IC50	754:757	arg1	values					759:764	IC50 values	754:764	IC50 values at 12 h and 24 h	754:781	IC50 values at 12 h and 24 h were 2.70 mg/mL and 2.85 mg/mL, respectively.
32653371	2	17	theme	stable	241:246	arg1	radical					257:263	the stable nitroxyl radical	237:263	the stable nitroxyl radical	237:263	After specific oxidation using the stable nitroxyl radical, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), together with NaBr and NaClO, glucoglucuronan (LAO) was obtained.
32653371	9	18	dep	showed	1114:1119	arg1	fluctuated					1256:1265	fluctuated	1256:1265	fluctuated	1256:1265	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	8	19	theme	cell	998:1001	arg1	proliferation					1003:1015	cancer cell proliferation	991:1015	cancer cell proliferation	991:1015	FAK, PI3K, P-AKT and mTOR were down-regulated, indicating LAO inhibited cancer cell proliferation through the FAK/PI3K/AKT/mTOR pathway.
32653371	2	20	dep	together	312:319	arg1	with					321:324	with	321:324	with	321:324	After specific oxidation using the stable nitroxyl radical, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), together with NaBr and NaClO, glucoglucuronan (LAO) was obtained.
32653371	0	21	theme	Structural	0:9	arg1	analysis					11:18	Structural analysis	0:18	Structural analysis of a	0:23	Structural analysis of a glucoglucuronan derived from laminarin and the mechanisms of its anti-lung cancer activity.
32653371	9	22	theme	factor	1198:1203	arg1	inhibition					1218:1227	fibroblast growth factor 1 (FGF1) LAO inhibition	1180:1227	fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2	1180:1254	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	9	23	theme	0.07 mg/mL	1132:1141	arg1	IC50					1124:1127	an IC50	1121:1127	an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2	1121:1254	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	3	24	theme	LAO	404:406	arg1	analysis					392:399	Compositional analysis	378:399	Compositional analysis of LAO	378:406	Compositional analysis of LAO showed a molar ratio of glucuronic acid (GlcA) to glucose (Glc) of 12.7: 1.
32653371	0	25	theme	a	23:23	arg1	analysis					11:18	Structural analysis	0:18	Structural analysis of a	0:23	Structural analysis of a glucoglucuronan derived from laminarin and the mechanisms of its anti-lung cancer activity.
32653371	8	26	theme	FAK/PI3K/AKT/mTOR	1029:1045	arg1	pathway					1047:1053	the FAK/PI3K/AKT/mTOR pathway	1025:1053	the FAK/PI3K/AKT/mTOR pathway	1025:1053	FAK, PI3K, P-AKT and mTOR were down-regulated, indicating LAO inhibited cancer cell proliferation through the FAK/PI3K/AKT/mTOR pathway.
32653371	9	27	theme	resonance	1072:1080	arg1	studies					1088:1094	Surface plasmon resonance (SPR) studies	1056:1094	Surface plasmon resonance (SPR) studies	1056:1094	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	3	28	theme	1	481:481	arg1	glucose					458:464	glucose	458:464	glucose (Glc) of 12.7: 1	458:481	Compositional analysis of LAO showed a molar ratio of glucuronic acid (GlcA) to glucose (Glc) of 12.7: 1.
32653371	3	28	theme	1	481:481	arg1	Glc					467:469	Glc	467:469	Glc	467:469	Compositional analysis of LAO showed a molar ratio of glucuronic acid (GlcA) to glucose (Glc) of 12.7: 1.
32653371	5	29	theme	human	702:706	arg1	proliferation					730:742	human lung cancer A549 cell proliferation	702:742	human lung cancer A549 cell proliferation	702:742	LAO inhibited human lung cancer A549 cell proliferation in vitro.
32653371	4	30	theme	magnetic	492:499	arg1	NMR					512:514	NMR	512:514	NMR	512:514	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
32653371	4	30	theme	magnetic	492:499	arg1	resonance					501:509	Nuclear magnetic resonance	484:509	Nuclear magnetic resonance (NMR)	484:515	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
32653371	3	31	theme	glucuronic	432:441	arg1	GlcA					449:452	GlcA	449:452	GlcA	449:452	Compositional analysis of LAO showed a molar ratio of glucuronic acid (GlcA) to glucose (Glc) of 12.7: 1.
32653371	3	31	theme	glucuronic	432:441	arg1	acid					443:446	glucuronic acid	432:446	glucuronic acid (GlcA)	432:453	Compositional analysis of LAO showed a molar ratio of glucuronic acid (GlcA) to glucose (Glc) of 12.7: 1.
32653371	3	32	theme	Compositional	378:390	arg1	analysis					392:399	Compositional analysis	378:399	Compositional analysis of LAO	378:406	Compositional analysis of LAO showed a molar ratio of glucuronic acid (GlcA) to glucose (Glc) of 12.7: 1.
32653371	4	33	theme	Nuclear	484:490	arg1	NMR					512:514	NMR	512:514	NMR	512:514	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
32653371	4	33	theme	Nuclear	484:490	arg1	resonance					501:509	Nuclear magnetic resonance	484:509	Nuclear magnetic resonance (NMR)	484:515	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
32653371	3	34	theme	molar	417:421	arg1	ratio					423:427	a molar ratio	415:427	a molar ratio of glucuronic acid (GlcA) to glucose (Glc) of 12.7: 1	415:481	Compositional analysis of LAO showed a molar ratio of glucuronic acid (GlcA) to glucose (Glc) of 12.7: 1.
32653371	1	35	theme	brown	173:177	arg1	thunbergii					194:203	the brown alga Sargassum thunbergii	169:203	the brown alga Sargassum thunbergii	169:203	Laminarin (LA), a storage glucan, was purified from the brown alga Sargassum thunbergii.
32653371	9	36	theme	heparin	1232:1238	arg1	binding					1240:1246	heparin binding	1232:1246	heparin binding to FGF2	1232:1254	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	1	37	theme	alga	179:182	arg1	thunbergii					194:203	the brown alga Sargassum thunbergii	169:203	the brown alga Sargassum thunbergii	169:203	Laminarin (LA), a storage glucan, was purified from the brown alga Sargassum thunbergii.
32653371	9	38	theme	LAO	1214:1216	arg1	inhibition					1218:1227	fibroblast growth factor 1 (FGF1) LAO inhibition	1180:1227	fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2	1180:1254	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	7	39	theme	3.80 mg/mL	907:916	arg1	concentration					890:902	an LAO concentration	883:902	an LAO concentration of 3.80 mg/mL	883:916	Western blotting showed that TSC2 was up-regulated at an LAO concentration of 3.80 mg/mL.
32653371	7	40	theme	LAO	886:888	arg1	concentration					890:902	an LAO concentration	883:902	an LAO concentration of 3.80 mg/mL	883:916	Western blotting showed that TSC2 was up-regulated at an LAO concentration of 3.80 mg/mL.
32653371	4	41	theme	β-D-GlcpA	592:600	arg1	backbone					565:572	a backbone	563:572	a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA	563:685	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
32653371	9	42	theme	binding	1240:1246	arg1	inhibition					1218:1227	fibroblast growth factor 1 (FGF1) LAO inhibition	1180:1227	fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2	1180:1254	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	0	43	dep	glucoglucuronan	25:39	arg1	derived					41:47	derived	41:47	glucoglucuronan derived from laminarin and the mechanisms of its anti-lung cancer activity	25:114	Structural analysis of a glucoglucuronan derived from laminarin and the mechanisms of its anti-lung cancer activity.
32653371	4	44	theme	-linked	584:590	arg1	β-D-GlcpA					592:600	(1 → 3)-linked β-D-GlcpA	577:600	(1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA	577:685	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
32653371	9	45	theme	fibroblast	1180:1189	arg1	factor					1198:1203	fibroblast growth factor 1	1180:1205	fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2	1180:1254	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	9	45	theme	fibroblast	1180:1189	arg1	FGF1					1208:1211	FGF1	1208:1211	FGF1	1208:1211	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	4	46	link	-linked	634:640	arg1	β-D-Glcp					642:649	-linked β-D-Glcp	634:649	-linked β-D-Glcp	634:649	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
32653371	4	47	dep	β-D-GlcpA	592:600	arg1	1 → 3					578:582	1 → 3	578:582	1 → 3	578:582	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
32653371	1	48	theme	Sargassum	184:192	arg1	thunbergii					194:203	the brown alga Sargassum thunbergii	169:203	the brown alga Sargassum thunbergii	169:203	Laminarin (LA), a storage glucan, was purified from the brown alga Sargassum thunbergii.
32653371	4	49	link	-linked	584:590	arg1	β-D-GlcpA					592:600	(1 → 3)-linked β-D-GlcpA	577:600	(1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA	577:685	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
32653371	4	50	dep	β-D-Glcp	642:649	arg1	1 → 6					628:632	1 → 6	628:632	1 → 6	628:632	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
32653371	4	50	dep	β-D-Glcp	642:649	arg1	1 → 3					621:625	1 → 3	621:625	1 → 3	621:625	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
32653371	3	51	theme	acid	443:446	arg1	ratio					423:427	a molar ratio	415:427	a molar ratio of glucuronic acid (GlcA) to glucose (Glc) of 12.7: 1	415:481	Compositional analysis of LAO showed a molar ratio of glucuronic acid (GlcA) to glucose (Glc) of 12.7: 1.
32653371	8	52	theme	cancer	991:996	arg1	proliferation					1003:1015	cancer cell proliferation	991:1015	cancer cell proliferation	991:1015	FAK, PI3K, P-AKT and mTOR were down-regulated, indicating LAO inhibited cancer cell proliferation through the FAK/PI3K/AKT/mTOR pathway.
32653371	5	53	theme	A549	720:723	arg1	proliferation					730:742	human lung cancer A549 cell proliferation	702:742	human lung cancer A549 cell proliferation	702:742	LAO inhibited human lung cancer A549 cell proliferation in vitro.
32653371	9	54	theme	cell	1322:1325	arg1	proliferation					1327:1339	A549 cell proliferation	1317:1339	A549 cell proliferation	1317:1339	Surface plasmon resonance (SPR) studies revealed that LAO showed an IC50 of 0.07 mg/mL inhibiting the binding of heparin to fibroblast growth factor 1 (FGF1) LAO inhibition of heparin binding to FGF2 fluctuated between 15% and 28%, suggesting that LAO inhibits A549 cell proliferation by selectively interacting with FGF1.
32653371	6	55	from	12 h	769:772	arg1	values					759:764	IC50 values	754:764	IC50 values at 12 h and 24 h	754:781	IC50 values at 12 h and 24 h were 2.70 mg/mL and 2.85 mg/mL, respectively.
32653371	2	56	theme	specific	212:219	arg1	oxidation					221:229	specific oxidation	212:229	specific oxidation using the stable nitroxyl radical	212:263	After specific oxidation using the stable nitroxyl radical, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), together with NaBr and NaClO, glucoglucuronan (LAO) was obtained.
32653371	4	57	theme	mass	521:524	arg1	MS					540:541	MS	540:541	MS	540:541	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
32653371	4	57	theme	mass	521:524	arg1	spectroscopy					526:537	mass spectroscopy	521:537	mass spectroscopy (MS)	521:542	Nuclear magnetic resonance (NMR) and mass spectroscopy (MS) showed LAO to have a backbone of (1 → 3)-linked β-D-GlcpA interspersed with (1 → 3, 1 → 6)-linked β-D-Glcp, that was terminated with β-D-GlcpA.
31917215	0	0	theme	anionic	90:96	arg1	dye					102:104	anionic azo dye	90:104	anionic azo dye	90:104	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.
31917215	5	1	theme	adsorption	967:976	arg1	process					978:984	The adsorption process	963:984	The adsorption process	963:984	The adsorption process followed the pseudo-second order (PSO) kinetic, and Freundlich isotherm models.
31917215	3	2	from	environment	703:713	arg1	orange					673:678	reactive orange 16	664:681	reactive orange 16 (RO16) from aqueous environment	664:713	The effectiveness of Chi-Gly/FA/Fe3O4 as an adsorbent was evaluated for the removal anionic azo dye such as reactive orange 16 (RO16) from aqueous environment.
31917215	3	2	from	environment	703:713	arg1	RO16					684:687	RO16	684:687	RO16	684:687	The effectiveness of Chi-Gly/FA/Fe3O4 as an adsorbent was evaluated for the removal anionic azo dye such as reactive orange 16 (RO16) from aqueous environment.
31917215	5	3	theme	order	1013:1017	arg1	PSO					1020:1022	the pseudo-second order (PSO) kinetic, and Freundlich isotherm models	995:1063	PSO	1020:1022	The adsorption process followed the pseudo-second order (PSO) kinetic, and Freundlich isotherm models.
31917215	4	4	dep	B	812:812	arg1	4-10					815:818	4-10	815:818	4-10	815:818	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	3	5	theme	azo	648:650	arg1	dye					652:654	the removal anionic azo dye	628:654	the removal anionic azo dye such as reactive orange 16 (RO16) from aqueous environment	628:713	The effectiveness of Chi-Gly/FA/Fe3O4 as an adsorbent was evaluated for the removal anionic azo dye such as reactive orange 16 (RO16) from aqueous environment.
31917215	4	6	dep	D	867:867	arg1	5-20 min					870:877	5-20 min	870:877	D: 5-20 min	867:877	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	7	from	design	911:916	arg1	RSM					957:959	RSM	957:959	RSM	957:959	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	7	from	design	911:916	arg1	methodology					944:954	response surface methodology	927:954	response surface methodology (RSM)	927:960	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	8	theme	solution	799:806	arg1	parameters					749:758	adsorption process parameters	730:758	adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min)	730:878	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	8	theme	solution	799:806	arg1	pH					808:809	solution pH	799:809	solution pH (B: 4-10)	799:819	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	0	9	theme	dye	102:104	arg1	removal					79:85	the removal	75:85	the removal of anionic azo dye	75:104	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.
31917215	1	10	theme	direct	268:273	arg1	compositing					275:285	direct compositing	268:285	direct compositing of magnetic chitosan (Chi)	268:312	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	0	11	theme	azo	98:100	arg1	dye					102:104	anionic azo dye	90:104	anionic azo dye	90:104	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.
31917215	1	12	theme	powder	332:337	arg1	particles					339:347	fly ash (FA) powder particles	319:347	fly ash (FA) powder particles	319:347	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	2	13	theme	Chi-Gly/FA/Fe3O4	525:540	arg1	biocomposite					542:553	Chi-Gly/FA/Fe3O4 biocomposite	525:553	Chi-Gly/FA/Fe3O4 biocomposite	525:553	Various techniques such as BET, XRD, FTIR, and SEM-EDX were utilized to characterize of Chi-Gly/FA/Fe3O4 biocomposite.
31917215	4	14	dep	temperature	822:832	arg1	C					835:835	C	835:835	C: 30-50 °C	835:845	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	8	15	theme	high	1378:1381	arg1	ability					1383:1389	a high ability	1376:1389	a high ability to separate from the aqueous solution after adsorption process by external magnetic field	1376:1479	Furthermore, the Chi-Gly/FA/Fe3O4 biocomposite exhibited a high ability to separate from the aqueous solution after adsorption process by external magnetic field.
31917215	6	16	theme	biocomposite	1118:1129	arg1	capacity					1089:1096	The maximum adsorption capacity	1066:1096	The maximum adsorption capacity of Chi-Gly/FA/Fe3O4 biocomposite for RO16 dye	1066:1142	The maximum adsorption capacity of Chi-Gly/FA/Fe3O4 biocomposite for RO16 dye was recorded to be 112.5 mg/g at 40 °C.
31917215	4	17	dep	dose	777:780	arg1	A					783:783	A	783:783	A: 0.02-0.1 g	783:795	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	7	18	theme	RO16	1188:1191	arg1	mechanism					1208:1216	The RO16 dye adsorption mechanism	1184:1216	The RO16 dye adsorption mechanism	1184:1216	The RO16 dye adsorption mechanism was attributed to various interactions such as electrostatic, n-π, H-bonding, and Yoshida H-bonding.
31917215	1	19	theme	new	146:148	arg1	Chi-Gly/FA/Fe3O4					218:233	Chi-Gly/FA/Fe3O4	218:233	Chi-Gly/FA/Fe3O4	218:233	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	1	19	theme	new	146:148	arg1	biocomposite					204:215	a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite	144:215	a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4)	144:234	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	3	20	theme	reactive	664:671	arg1	orange					673:678	reactive orange 16	664:681	reactive orange 16 (RO16) from aqueous environment	664:713	The effectiveness of Chi-Gly/FA/Fe3O4 as an adsorbent was evaluated for the removal anionic azo dye such as reactive orange 16 (RO16) from aqueous environment.
31917215	3	20	theme	reactive	664:671	arg1	RO16					684:687	RO16	684:687	RO16	684:687	The effectiveness of Chi-Gly/FA/Fe3O4 as an adsorbent was evaluated for the removal anionic azo dye such as reactive orange 16 (RO16) from aqueous environment.
31917215	2	21	theme	Various	437:443	arg1	SEM-EDX					484:490	SEM-EDX	484:490	SEM-EDX	484:490	Various techniques such as BET, XRD, FTIR, and SEM-EDX were utilized to characterize of Chi-Gly/FA/Fe3O4 biocomposite.
31917215	2	21	theme	Various	437:443	arg1	XRD					469:471	XRD	469:471	XRD	469:471	Various techniques such as BET, XRD, FTIR, and SEM-EDX were utilized to characterize of Chi-Gly/FA/Fe3O4 biocomposite.
31917215	2	21	theme	Various	437:443	arg1	techniques					445:454	Various techniques	437:454	Various techniques such as BET, XRD, FTIR, and SEM-EDX	437:490	Various techniques such as BET, XRD, FTIR, and SEM-EDX were utilized to characterize of Chi-Gly/FA/Fe3O4 biocomposite.
31917215	2	21	theme	Various	437:443	arg1	BET					464:466	BET	464:466	BET	464:466	Various techniques such as BET, XRD, FTIR, and SEM-EDX were utilized to characterize of Chi-Gly/FA/Fe3O4 biocomposite.
31917215	2	21	theme	Various	437:443	arg1	FTIR					474:477	FTIR	474:477	FTIR	474:477	Various techniques such as BET, XRD, FTIR, and SEM-EDX were utilized to characterize of Chi-Gly/FA/Fe3O4 biocomposite.
31917215	8	22	theme	external	1457:1464	arg1	field					1475:1479	external magnetic field	1457:1479	external magnetic field	1457:1479	Furthermore, the Chi-Gly/FA/Fe3O4 biocomposite exhibited a high ability to separate from the aqueous solution after adsorption process by external magnetic field.
31917215	1	23	theme	magnetic	150:157	arg1	Chi-Gly/FA/Fe3O4					218:233	Chi-Gly/FA/Fe3O4	218:233	Chi-Gly/FA/Fe3O4	218:233	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	1	23	theme	magnetic	150:157	arg1	biocomposite					204:215	a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite	144:215	a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4)	144:234	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	0	24	theme	magnetic	4:11	arg1	biocomposite					58:69	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite	0:69	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.	0:127	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.
31917215	5	25	theme	kinetic	1025:1031	arg1	PSO					1020:1022	the pseudo-second order (PSO) kinetic, and Freundlich isotherm models	995:1063	PSO	1020:1022	The adsorption process followed the pseudo-second order (PSO) kinetic, and Freundlich isotherm models.
31917215	8	26	from	solution	1420:1427	arg1	separate					1394:1401	separate	1394:1401	separate	1394:1401	Furthermore, the Chi-Gly/FA/Fe3O4 biocomposite exhibited a high ability to separate from the aqueous solution after adsorption process by external magnetic field.
31917215	0	27	theme	New	0:2	arg1	biocomposite					58:69	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite	0:69	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.	0:127	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.
31917215	3	28	theme	removal	632:638	arg1	dye					652:654	the removal anionic azo dye	628:654	the removal anionic azo dye such as reactive orange 16 (RO16) from aqueous environment	628:713	The effectiveness of Chi-Gly/FA/Fe3O4 as an adsorbent was evaluated for the removal anionic azo dye such as reactive orange 16 (RO16) from aqueous environment.
31917215	4	29	theme	Box-Behnken	899:909	arg1	BBD					919:921	BBD	919:921	BBD	919:921	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	29	theme	Box-Behnken	899:909	arg1	design					911:916	Box-Behnken design	899:916	Box-Behnken design (BBD) in response surface methodology (RSM)	899:960	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	1	30	theme	magnetic	290:297	arg1	chitosan					299:306	magnetic chitosan	290:306	magnetic chitosan (Chi)	290:312	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	1	30	theme	magnetic	290:297	arg1	Chi					309:311	Chi	309:311	Chi	309:311	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	7	31	theme	dye	1193:1195	arg1	mechanism					1208:1216	The RO16 dye adsorption mechanism	1184:1216	The RO16 dye adsorption mechanism	1184:1216	The RO16 dye adsorption mechanism was attributed to various interactions such as electrostatic, n-π, H-bonding, and Yoshida H-bonding.
31917215	6	32	theme	adsorption	1078:1087	arg1	capacity					1089:1096	The maximum adsorption capacity	1066:1096	The maximum adsorption capacity of Chi-Gly/FA/Fe3O4 biocomposite for RO16 dye	1066:1142	The maximum adsorption capacity of Chi-Gly/FA/Fe3O4 biocomposite for RO16 dye was recorded to be 112.5 mg/g at 40 °C.
31917215	1	33	theme	base-chitosan-glyoxal/fly	168:192	arg1	Chi-Gly/FA/Fe3O4					218:233	Chi-Gly/FA/Fe3O4	218:233	Chi-Gly/FA/Fe3O4	218:233	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	1	33	theme	base-chitosan-glyoxal/fly	168:192	arg1	biocomposite					204:215	a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite	144:215	a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4)	144:234	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	4	34	dep	A	783:783	arg1	0.02-0.1 g					786:795	0.02-0.1 g	786:795	A: 0.02-0.1 g	783:795	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	1	35	theme	chitosan	299:306	arg1	compositing					275:285	direct compositing	268:285	direct compositing of magnetic chitosan (Chi)	268:312	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	0	36	theme	optimized	110:118	arg1	process					120:126	An optimized process	107:126	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.	0:127	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.
31917215	1	37	theme	ash/Fe3O4	194:202	arg1	Chi-Gly/FA/Fe3O4					218:233	Chi-Gly/FA/Fe3O4	218:233	Chi-Gly/FA/Fe3O4	218:233	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	1	37	theme	ash/Fe3O4	194:202	arg1	biocomposite					204:215	a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite	144:215	a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4)	144:234	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	0	38	theme	ash/Fe3O4	48:56	arg1	biocomposite					58:69	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite	0:69	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.	0:127	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.
31917215	8	39	theme	aqueous	1412:1418	arg1	solution					1420:1427	the aqueous solution	1408:1427	the aqueous solution after adsorption	1408:1444	Furthermore, the Chi-Gly/FA/Fe3O4 biocomposite exhibited a high ability to separate from the aqueous solution after adsorption process by external magnetic field.
31917215	4	40	theme	adsorbent	767:775	arg1	parameters					749:758	adsorption process parameters	730:758	adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min)	730:878	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	40	theme	adsorbent	767:775	arg1	dose					777:780	adsorbent dose	767:780	adsorbent dose (A: 0.02-0.1 g)	767:796	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	5	41	theme	Freundlich	1038:1047	arg1	models					1058:1063	the pseudo-second order (PSO) kinetic, and Freundlich isotherm models	995:1063	models	1058:1063	The adsorption process followed the pseudo-second order (PSO) kinetic, and Freundlich isotherm models.
31917215	0	42	theme	base-chitosan-glyoxal/fly	22:46	arg1	biocomposite					58:69	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite	0:69	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.	0:127	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.
31917215	4	43	dep	pH	808:809	arg1	B					812:812	B	812:812	B: 4-10	812:818	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	0	44	dep	biocomposite	58:69	arg1	process					120:126	An optimized process	107:126	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.	0:127	New magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite for the removal of anionic azo dye: An optimized process.
31917215	4	45	dep	C	835:835	arg1	30-50 °C					838:845	30-50 °C	838:845	C: 30-50 °C	835:845	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	3	46	theme	aqueous	695:701	arg1	environment					703:713	aqueous environment	695:713	aqueous environment	695:713	The effectiveness of Chi-Gly/FA/Fe3O4 as an adsorbent was evaluated for the removal anionic azo dye such as reactive orange 16 (RO16) from aqueous environment.
31917215	8	47	theme	Chi-Gly/FA/Fe3O4	1336:1351	arg1	biocomposite					1353:1364	the Chi-Gly/FA/Fe3O4 biocomposite	1332:1364	the Chi-Gly/FA/Fe3O4 biocomposite	1332:1364	Furthermore, the Chi-Gly/FA/Fe3O4 biocomposite exhibited a high ability to separate from the aqueous solution after adsorption process by external magnetic field.
31917215	8	48	theme	separate	1394:1401	arg1	process					1446:1452	separate from the aqueous solution after adsorption process	1394:1452	separate from the aqueous solution after adsorption process	1394:1452	Furthermore, the Chi-Gly/FA/Fe3O4 biocomposite exhibited a high ability to separate from the aqueous solution after adsorption process by external magnetic field.
31917215	4	49	dep	parameters	749:758	arg1	time					861:864	contact time	853:864	contact time (D: 5-20 min)	853:878	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	49	dep	parameters	749:758	arg1	dose					777:780	adsorbent dose	767:780	adsorbent dose (A: 0.02-0.1 g)	767:796	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	49	dep	parameters	749:758	arg1	parameters					749:758	adsorption process parameters	730:758	adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min)	730:878	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	49	dep	parameters	749:758	arg1	pH					808:809	solution pH	799:809	solution pH (B: 4-10)	799:819	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	49	dep	parameters	749:758	arg1	temperature					822:832	temperature	822:832	temperature (C: 30-50 °C)	822:846	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	1	50	with	reaction	408:415	arg1	glyoxal					422:428	glyoxal	422:428	glyoxal (Gly)	422:434	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	1	50	with	reaction	408:415	arg1	Gly					431:433	Gly	431:433	Gly	431:433	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	4	51	dep	time	861:864	arg1	D					867:867	D	867:867	D: 5-20 min	867:877	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	1	52	theme	base	375:378	arg1	formation					380:388	Schiff's base formation	366:388	Schiff's base formation	366:388	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	6	53	theme	Chi-Gly/FA/Fe3O4	1101:1116	arg1	biocomposite					1118:1129	Chi-Gly/FA/Fe3O4 biocomposite	1101:1129	Chi-Gly/FA/Fe3O4 biocomposite	1101:1129	The maximum adsorption capacity of Chi-Gly/FA/Fe3O4 biocomposite for RO16 dye was recorded to be 112.5 mg/g at 40 °C.
31917215	4	54	theme	response	927:934	arg1	RSM					957:959	RSM	957:959	RSM	957:959	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	54	theme	response	927:934	arg1	methodology					944:954	response surface methodology	927:954	response surface methodology (RSM)	927:960	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	1	55	theme	fly	319:321	arg1	FA					328:329	FA	328:329	FA	328:329	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	1	55	theme	fly	319:321	arg1	ash					323:325	fly ash	319:325	fly ash (FA) powder particles	319:347	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	3	56	theme	anionic	640:646	arg1	dye					652:654	the removal anionic azo dye	628:654	the removal anionic azo dye such as reactive orange 16 (RO16) from aqueous environment	628:713	The effectiveness of Chi-Gly/FA/Fe3O4 as an adsorbent was evaluated for the removal anionic azo dye such as reactive orange 16 (RO16) from aqueous environment.
31917215	3	57	theme	Chi-Gly/FA/Fe3O4	577:592	arg1	effectiveness					560:572	The effectiveness	556:572	The effectiveness of Chi-Gly/FA/Fe3O4 as an adsorbent	556:608	The effectiveness of Chi-Gly/FA/Fe3O4 as an adsorbent was evaluated for the removal anionic azo dye such as reactive orange 16 (RO16) from aqueous environment.
31917215	6	58	theme	maximum	1070:1076	arg1	capacity					1089:1096	The maximum adsorption capacity	1066:1096	The maximum adsorption capacity of Chi-Gly/FA/Fe3O4 biocomposite for RO16 dye	1066:1142	The maximum adsorption capacity of Chi-Gly/FA/Fe3O4 biocomposite for RO16 dye was recorded to be 112.5 mg/g at 40 °C.
31917215	2	59	used	utilized	497:504	arg2	FTIR					474:477	FTIR	474:477	FTIR	474:477	Various techniques such as BET, XRD, FTIR, and SEM-EDX were utilized to characterize of Chi-Gly/FA/Fe3O4 biocomposite.
31917215	2	59	used	utilized	497:504	arg2	techniques					445:454	Various techniques	437:454	Various techniques such as BET, XRD, FTIR, and SEM-EDX	437:490	Various techniques such as BET, XRD, FTIR, and SEM-EDX were utilized to characterize of Chi-Gly/FA/Fe3O4 biocomposite.
31917215	2	59	used	utilized	497:504	arg2	XRD					469:471	XRD	469:471	XRD	469:471	Various techniques such as BET, XRD, FTIR, and SEM-EDX were utilized to characterize of Chi-Gly/FA/Fe3O4 biocomposite.
31917215	2	59	used	utilized	497:504	arg2	BET					464:466	BET	464:466	BET	464:466	Various techniques such as BET, XRD, FTIR, and SEM-EDX were utilized to characterize of Chi-Gly/FA/Fe3O4 biocomposite.
31917215	2	59	used	utilized	497:504	arg2	SEM-EDX					484:490	SEM-EDX	484:490	SEM-EDX	484:490	Various techniques such as BET, XRD, FTIR, and SEM-EDX were utilized to characterize of Chi-Gly/FA/Fe3O4 biocomposite.
31917215	7	60	theme	adsorption	1197:1206	arg1	mechanism					1208:1216	The RO16 dye adsorption mechanism	1184:1216	The RO16 dye adsorption mechanism	1184:1216	The RO16 dye adsorption mechanism was attributed to various interactions such as electrostatic, n-π, H-bonding, and Yoshida H-bonding.
31917215	4	61	theme	adsorption	730:739	arg1	time					861:864	contact time	853:864	contact time (D: 5-20 min)	853:878	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	61	theme	adsorption	730:739	arg1	dose					777:780	adsorbent dose	767:780	adsorbent dose (A: 0.02-0.1 g)	767:796	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	61	theme	adsorption	730:739	arg1	parameters					749:758	adsorption process parameters	730:758	adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min)	730:878	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	61	theme	adsorption	730:739	arg1	pH					808:809	solution pH	799:809	solution pH (B: 4-10)	799:819	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	61	theme	adsorption	730:739	arg1	temperature					822:832	temperature	822:832	temperature (C: 30-50 °C)	822:846	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	62	theme	contact	853:859	arg1	parameters					749:758	adsorption process parameters	730:758	adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min)	730:878	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	62	theme	contact	853:859	arg1	time					861:864	contact time	853:864	contact time (D: 5-20 min)	853:878	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	1	63	theme	cross-linking	394:406	arg1	reaction					408:415	cross-linking reaction	394:415	cross-linking reaction with glyoxal (Gly)	394:434	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	4	64	theme	parameters	749:758	arg1	effect					720:725	The effect	716:725	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min)	716:878	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	65	theme	surface	936:942	arg1	RSM					957:959	RSM	957:959	RSM	957:959	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	65	theme	surface	936:942	arg1	methodology					944:954	response surface methodology	927:954	response surface methodology (RSM)	927:960	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	5	66	theme	isotherm	1049:1056	arg1	models					1058:1063	the pseudo-second order (PSO) kinetic, and Freundlich isotherm models	995:1063	models	1058:1063	The adsorption process followed the pseudo-second order (PSO) kinetic, and Freundlich isotherm models.
31917215	1	67	theme	ash	323:325	arg1	particles					339:347	fly ash (FA) powder particles	319:347	fly ash (FA) powder particles	319:347	In this study, a new magnetic Schiff's base-chitosan-glyoxal/fly ash/Fe3O4 biocomposite (Chi-Gly/FA/Fe3O4) was successfully synthesized by direct compositing of magnetic chitosan (Chi) with fly ash (FA) powder particles, and followed by Schiff's base formation via cross-linking reaction with glyoxal (Gly).
31917215	4	68	theme	process	741:747	arg1	time					861:864	contact time	853:864	contact time (D: 5-20 min)	853:878	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	68	theme	process	741:747	arg1	dose					777:780	adsorbent dose	767:780	adsorbent dose (A: 0.02-0.1 g)	767:796	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	68	theme	process	741:747	arg1	parameters					749:758	adsorption process parameters	730:758	adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min)	730:878	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	68	theme	process	741:747	arg1	pH					808:809	solution pH	799:809	solution pH (B: 4-10)	799:819	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	4	68	theme	process	741:747	arg1	temperature					822:832	temperature	822:832	temperature (C: 30-50 °C)	822:846	The effect of adsorption process parameters namely adsorbent dose (A: 0.02-0.1 g), solution pH (B: 4-10), temperature (C: 30-50 °C), and contact time (D: 5-20 min) were optimized via Box-Behnken design (BBD) in response surface methodology (RSM).
31917215	8	69	theme	magnetic	1466:1473	arg1	field					1475:1479	external magnetic field	1457:1479	external magnetic field	1457:1479	Furthermore, the Chi-Gly/FA/Fe3O4 biocomposite exhibited a high ability to separate from the aqueous solution after adsorption process by external magnetic field.
31917215	7	70	theme	various	1236:1242	arg1	Yoshida					1300:1306	Yoshida	1300:1306	Yoshida	1300:1306	The RO16 dye adsorption mechanism was attributed to various interactions such as electrostatic, n-π, H-bonding, and Yoshida H-bonding.
31917215	7	70	theme	various	1236:1242	arg1	n-π					1280:1282	n-π	1280:1282	n-π	1280:1282	The RO16 dye adsorption mechanism was attributed to various interactions such as electrostatic, n-π, H-bonding, and Yoshida H-bonding.
31917215	7	70	theme	various	1236:1242	arg1	interactions					1244:1255	various interactions	1236:1255	various interactions such as electrostatic, n-π, H-bonding, and Yoshida H-bonding	1236:1316	The RO16 dye adsorption mechanism was attributed to various interactions such as electrostatic, n-π, H-bonding, and Yoshida H-bonding.
31917215	7	70	theme	various	1236:1242	arg1	electrostatic					1265:1277	electrostatic	1265:1277	electrostatic	1265:1277	The RO16 dye adsorption mechanism was attributed to various interactions such as electrostatic, n-π, H-bonding, and Yoshida H-bonding.
31917215	7	70	theme	various	1236:1242	arg1	H-bonding					1285:1293	H-bonding	1285:1293	H-bonding	1285:1293	The RO16 dye adsorption mechanism was attributed to various interactions such as electrostatic, n-π, H-bonding, and Yoshida H-bonding.
31917215	5	71	theme	pseudo-second	999:1011	arg1	PSO					1020:1022	the pseudo-second order (PSO) kinetic, and Freundlich isotherm models	995:1063	PSO	1020:1022	The adsorption process followed the pseudo-second order (PSO) kinetic, and Freundlich isotherm models.
32184139	8	0	theme	formulations	1106:1117	arg1	potential					1082:1090	high potential	1077:1090	high potential of the tested formulations for application in wound healing	1077:1150	According to the obtained results, high potential of the tested formulations for application in wound healing was corroborated.
32184139	3	1	theme	gel	506:508	arg1	absorption					494:503	water absorption	488:503	water absorption	488:503	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	3	1	theme	gel	506:508	arg1	content					510:516	gel content	506:516	gel content	506:516	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	4	2	theme	FT-IR	578:582	arg1	spectra					584:590	FT-IR spectra	578:590	FT-IR spectra of the samples	578:605	FT-IR spectra of the samples showed no chemical reaction between the constituents.
32184139	0	3	theme	films	76:80	arg1	Physical					0:7	Physical	0:7	Physical	0:7	Physical, mechanical and wound healing properties of chitosan/gelatin blend films containing tannic acid and/or bacterial nanocellulose.
32184139	8	4	from	application	1123:1133	arg1	healing					1144:1150	wound healing	1138:1150	wound healing	1138:1150	According to the obtained results, high potential of the tested formulations for application in wound healing was corroborated.
32184139	7	5	theme	wound	1026:1030	arg1	dressing					1032:1039	any wound dressing	1022:1039	any wound dressing	1022:1039	Also, in-vivo tests on Wistar rats demonstrated that amount of contraction is at least 15% higher for the wounds treated using each of the films compared to those treated without any wound dressing.
32184139	7	6	theme	Wistar	866:871	arg1	rats					873:876	Wistar rats	866:876	Wistar rats	866:876	Also, in-vivo tests on Wistar rats demonstrated that amount of contraction is at least 15% higher for the wounds treated using each of the films compared to those treated without any wound dressing.
32184139	0	7	theme	tannic	93:98	arg1	acid					100:103	tannic acid	93:103	tannic acid	93:103	Physical, mechanical and wound healing properties of chitosan/gelatin blend films containing tannic acid and/or bacterial nanocellulose.
32184139	7	8	theme	in-vivo	849:855	arg1	tests					857:861	in-vivo tests	849:861	in-vivo tests on Wistar rats	849:876	Also, in-vivo tests on Wistar rats demonstrated that amount of contraction is at least 15% higher for the wounds treated using each of the films compared to those treated without any wound dressing.
32184139	3	9	theme	water	488:492	arg1	absorption					494:503	water absorption	488:503	water absorption	488:503	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	3	9	theme	water	488:492	arg1	content					510:516	gel content	506:516	gel content	506:516	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	3	9	theme	water	488:492	arg1	permeability					531:542	water vapor permeability	519:542	water vapor permeability	519:542	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	0	10	theme	bacterial	112:120	arg1	nanocellulose					122:134	bacterial nanocellulose	112:134	bacterial nanocellulose	112:134	Physical, mechanical and wound healing properties of chitosan/gelatin blend films containing tannic acid and/or bacterial nanocellulose.
32184139	3	11	theme	vapor	525:529	arg1	absorption					494:503	water absorption	488:503	water absorption	488:503	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	3	11	theme	vapor	525:529	arg1	permeability					531:542	water vapor permeability	519:542	water vapor permeability	519:542	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	1	12	theme	new	167:169	arg1	composition					171:181	a new composition	165:181	a new composition for wound dressing having desired properties using naturally occurring materials	165:262	This study aimed to prepare a new composition for wound dressing having desired properties using naturally occurring materials.
32184139	5	13	from	dispersion	701:710	arg1	matrix					736:741	the matrix	732:741	the matrix	732:741	Moreover, SEM images proved a desirable dispersion of nanocellulose in the matrix.
32184139	8	14	theme	wound	1138:1142	arg1	healing					1144:1150	wound healing	1138:1150	wound healing	1138:1150	According to the obtained results, high potential of the tested formulations for application in wound healing was corroborated.
32184139	8	15	theme	tested	1099:1104	arg1	formulations					1106:1117	the tested formulations	1095:1117	the tested formulations	1095:1117	According to the obtained results, high potential of the tested formulations for application in wound healing was corroborated.
32184139	2	16	theme	tannic	328:333	arg1	acid					335:338	tannic acid	328:338	tannic acid	328:338	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	3	17	theme	electron	441:448	arg1	SEM					462:464	SEM	462:464	SEM	462:464	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	3	17	theme	electron	441:448	arg1	microscopy					450:459	scanning electron microscopy	432:459	scanning electron microscopy (SEM)	432:465	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	6	18	theme	acid	789:792	arg1	Incorporation					744:756	Incorporation	744:756	Incorporation of nanocellulose and/or tannic acid into the films	744:807	Incorporation of nanocellulose and/or tannic acid into the films was shown to reinforce the films.
32184139	1	19	theme	wound	187:191	arg1	dressing					193:200	wound dressing	187:200	wound dressing having desired properties using naturally occurring materials	187:262	This study aimed to prepare a new composition for wound dressing having desired properties using naturally occurring materials.
32184139	5	20	theme	desirable	691:699	arg1	dispersion					701:710	a desirable dispersion	689:710	a desirable dispersion of nanocellulose in the matrix	689:741	Moreover, SEM images proved a desirable dispersion of nanocellulose in the matrix.
32184139	6	21	theme	tannic	782:787	arg1	acid					789:792	tannic acid	782:792	tannic acid	782:792	Incorporation of nanocellulose and/or tannic acid into the films was shown to reinforce the films.
32184139	3	22	theme	XRD	468:470	arg1	experiments					472:482	XRD experiments	468:482	XRD experiments	468:482	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	2	23	theme	various	309:315	arg1	amounts					317:323	various amounts	309:323	various amounts of tannic acid and/or bacterial nanocellulose	309:369	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	2	23	theme	various	309:315	arg1	acid					335:338	tannic acid	328:338	tannic acid	328:338	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	2	23	theme	various	309:315	arg1	nanocellulose					357:369	bacterial nanocellulose	347:369	bacterial nanocellulose	347:369	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	4	24	theme	chemical	617:624	arg1	reaction					626:633	no chemical reaction	614:633	no chemical reaction between the constituents	614:658	FT-IR spectra of the samples showed no chemical reaction between the constituents.
32184139	2	25	contain	containing	298:307	arg1	films					292:296	Chitosan/gelatin (1:2 w/w) films	265:296	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose	265:369	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	2	25	contain	containing	298:307	arg2	acid					335:338	tannic acid	328:338	tannic acid	328:338	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	2	25	contain	containing	298:307	arg2	amounts					317:323	various amounts	309:323	various amounts of tannic acid and/or bacterial nanocellulose	309:369	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	2	25	contain	containing	298:307	arg2	nanocellulose					357:369	bacterial nanocellulose	347:369	bacterial nanocellulose	347:369	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	8	26	theme	obtained	1059:1066	arg1	results					1068:1074	the obtained results	1055:1074	the obtained results	1055:1074	According to the obtained results, high potential of the tested formulations for application in wound healing was corroborated.
32184139	1	27	theme	desired	209:215	arg1	properties					217:226	desired properties	209:226	desired properties using naturally occurring materials	209:262	This study aimed to prepare a new composition for wound dressing having desired properties using naturally occurring materials.
32184139	0	28	theme	wound	25:29	arg1	healing					31:37	wound healing	25:37	wound healing	25:37	Physical, mechanical and wound healing properties of chitosan/gelatin blend films containing tannic acid and/or bacterial nanocellulose.
32184139	3	29	theme	scanning	432:439	arg1	SEM					462:464	SEM	462:464	SEM	462:464	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	3	29	theme	scanning	432:439	arg1	microscopy					450:459	scanning electron microscopy	432:459	scanning electron microscopy (SEM)	432:465	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	3	30	theme	FT-IR	412:416	arg1	spectroscopy					418:429	FT-IR spectroscopy	412:429	FT-IR spectroscopy	412:429	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	5	31	theme	SEM	671:673	arg1	images					675:680	SEM images	671:680	SEM images	671:680	Moreover, SEM images proved a desirable dispersion of nanocellulose in the matrix.
32184139	6	32	theme	nanocellulose	761:773	arg1	Incorporation					744:756	Incorporation	744:756	Incorporation of nanocellulose and/or tannic acid into the films	744:807	Incorporation of nanocellulose and/or tannic acid into the films was shown to reinforce the films.
32184139	2	33	theme	nanocellulose	357:369	arg1	amounts					317:323	various amounts	309:323	various amounts of tannic acid and/or bacterial nanocellulose	309:369	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	2	33	theme	nanocellulose	357:369	arg1	acid					335:338	tannic acid	328:338	tannic acid	328:338	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	2	33	theme	nanocellulose	357:369	arg1	nanocellulose					357:369	bacterial nanocellulose	347:369	bacterial nanocellulose	347:369	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	5	34	theme	nanocellulose	715:727	arg1	dispersion					701:710	a desirable dispersion	689:710	a desirable dispersion of nanocellulose in the matrix	689:741	Moreover, SEM images proved a desirable dispersion of nanocellulose in the matrix.
32184139	2	35	theme	bacterial	347:355	arg1	nanocellulose					357:369	bacterial nanocellulose	347:369	bacterial nanocellulose	347:369	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	3	36	theme	in-vivo	563:569	arg1	tests					571:575	in-vivo tests	563:575	in-vivo tests	563:575	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	7	37	from	tests	857:861	arg1	rats					873:876	Wistar rats	866:876	Wistar rats	866:876	Also, in-vivo tests on Wistar rats demonstrated that amount of contraction is at least 15% higher for the wounds treated using each of the films compared to those treated without any wound dressing.
32184139	7	38	theme	contraction	906:916	arg1	amount					896:901	amount	896:901	amount of contraction	896:916	Also, in-vivo tests on Wistar rats demonstrated that amount of contraction is at least 15% higher for the wounds treated using each of the films compared to those treated without any wound dressing.
32184139	7	38	theme	contraction	906:916	arg1	contraction					906:916	contraction	906:916	contraction	906:916	Also, in-vivo tests on Wistar rats demonstrated that amount of contraction is at least 15% higher for the wounds treated using each of the films compared to those treated without any wound dressing.
32184139	4	39	theme	samples	599:605	arg1	spectra					584:590	FT-IR spectra	578:590	FT-IR spectra of the samples	578:605	FT-IR spectra of the samples showed no chemical reaction between the constituents.
32184139	8	40	theme	high	1077:1080	arg1	potential					1082:1090	high potential	1077:1090	high potential of the tested formulations for application in wound healing	1077:1150	According to the obtained results, high potential of the tested formulations for application in wound healing was corroborated.
32184139	1	41	contain	having	202:207	arg2	properties					217:226	desired properties	209:226	desired properties using naturally occurring materials	209:262	This study aimed to prepare a new composition for wound dressing having desired properties using naturally occurring materials.
32184139	1	41	contain	having	202:207	arg1	dressing					193:200	wound dressing	187:200	wound dressing having desired properties using naturally occurring materials	187:262	This study aimed to prepare a new composition for wound dressing having desired properties using naturally occurring materials.
32184139	2	42	theme	acid	335:338	arg1	amounts					317:323	various amounts	309:323	various amounts of tannic acid and/or bacterial nanocellulose	309:369	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	2	42	theme	acid	335:338	arg1	acid					335:338	tannic acid	328:338	tannic acid	328:338	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	2	42	theme	acid	335:338	arg1	nanocellulose					357:369	bacterial nanocellulose	347:369	bacterial nanocellulose	347:369	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	0	43	theme	blend	70:74	arg1	films					76:80	chitosan/gelatin blend films	53:80	chitosan/gelatin blend films	53:80	Physical, mechanical and wound healing properties of chitosan/gelatin blend films containing tannic acid and/or bacterial nanocellulose.
32184139	2	44	theme	Chitosan/gelatin	265:280	arg1	films					292:296	Chitosan/gelatin (1:2 w/w) films	265:296	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose	265:369	Chitosan/gelatin (1:2 w/w) films containing various amounts of tannic acid and/or bacterial nanocellulose were prepared.
32184139	1	45	theme	occurring	244:252	arg1	materials					254:262	naturally occurring materials	234:262	naturally occurring materials	234:262	This study aimed to prepare a new composition for wound dressing having desired properties using naturally occurring materials.
32184139	0	46	theme	chitosan/gelatin	53:68	arg1	films					76:80	chitosan/gelatin blend films	53:80	chitosan/gelatin blend films	53:80	Physical, mechanical and wound healing properties of chitosan/gelatin blend films containing tannic acid and/or bacterial nanocellulose.
32184139	0	47	dep	Physical	0:7	arg1	properties					39:48	properties	39:48	properties	39:48	Physical, mechanical and wound healing properties of chitosan/gelatin blend films containing tannic acid and/or bacterial nanocellulose.
32184139	3	48	theme	water	519:523	arg1	absorption					494:503	water absorption	488:503	water absorption	488:503	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
32184139	3	48	theme	water	519:523	arg1	permeability					531:542	water vapor permeability	519:542	water vapor permeability	519:542	The films were studied by FT-IR spectroscopy, scanning electron microscopy (SEM), XRD experiments and water absorption, gel content, water vapor permeability, mechanical and in in-vivo tests.
34217291	13	0	theme	protoplast	2530:2539	arg1	formation					2541:2549	protoplast formation	2530:2549	protoplast formation	2530:2549	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	12	1	theme	environmental	2310:2322	arg1	changes					2324:2330	environmental changes	2310:2330	environmental changes	2310:2330	This new commercial endo-β(1,3)-D-glucanase will allow the study of the cell wall composition under different conditions, along the cell cycle, in response to environmental changes or in cell wall mutants.
34217291	8	2	theme	polymers	1558:1565	arg1	release					1541:1547	the release	1537:1547	the release of other polymers	1537:1565	We found that the GH16 endo-β(1,3)-D-glucanase PfLam16A from Pyrococcus furiosus was able to completely and reproducibly degrade β(1,3)-D-glucan without causing the release of other polymers.
34217291	11	3	theme	endo-β	1967:1972	arg1	-D-glucanase					1978:1989	a reliable and efficient recombinant endo-β(1,3)-D-glucanase	1930:1989	a reliable and efficient recombinant endo-β(1,3)-D-glucanase	1930:1989	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	6	4	theme	analysis	1150:1157	arg1	protocol					1120:1127	a fast and reliable protocol	1100:1127	a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall	1100:1188	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	13	5	theme	chromosomes	2485:2495	arg1	extraction					2497:2506	chromosomes extraction	2485:2506	chromosomes extraction	2485:2506	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	7	6	theme	1,6	1361:1363	arg1	-D-glucan					1365:1373	β(1,6)-D-glucan	1359:1373	β(1,6)-D-glucan	1359:1373	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	7	6	theme	1,6	1361:1363	arg1	polymers					1297:1304	the four main polymers	1283:1304	the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan	1283:1373	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	11	7	theme	capable	1992:1998	arg1	-D-glucanase					1978:1989	a reliable and efficient recombinant endo-β(1,3)-D-glucanase	1930:1989	a reliable and efficient recombinant endo-β(1,3)-D-glucanase	1930:1989	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	11	8	theme	cell	2124:2127	arg1	wall					2129:2132	the fungal cell wall	2113:2132	the fungal cell wall β(1,3)-D-glucan	2113:2148	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	6	9	theme	cell	1180:1183	arg1	wall					1185:1188	the fission yeast cell wall	1162:1188	the fission yeast cell wall	1162:1188	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	11	10	theme	mentioned	2028:2036	arg1	enzyme					2038:2043	the previously mentioned enzyme	2013:2043	the previously mentioned enzyme	2013:2043	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	7	11	dep	polymers	1297:1304	arg1	polymers					1297:1304	the four main polymers	1283:1304	the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan	1283:1373	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	7	11	dep	polymers	1297:1304	arg1	-D-glucan					1365:1373	β(1,6)-D-glucan	1359:1373	β(1,6)-D-glucan	1359:1373	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	7	11	dep	polymers	1297:1304	arg1	-D-glucan					1345:1353	β(1,3)-D-glucan	1339:1353	β(1,3)-D-glucan	1339:1353	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	7	11	dep	polymers	1297:1304	arg1	α-glucan					1329:1336	α-glucan	1329:1336	α-glucan	1329:1336	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	7	11	dep	polymers	1297:1304	arg1	galactomannoproteins					1307:1326	galactomannoproteins	1307:1326	galactomannoproteins	1307:1326	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	7	12	theme	β	1359:1359	arg1	-D-glucan					1365:1373	β(1,6)-D-glucan	1359:1373	β(1,6)-D-glucan	1359:1373	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	7	12	theme	β	1359:1359	arg1	polymers					1297:1304	the four main polymers	1283:1304	the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan	1283:1373	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	11	13	theme	-D-glucanase	1978:1989	arg1	useful					2054:2059	useful	2054:2059	useful	2054:2059	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	11	13	theme	-D-glucanase	1978:1989	arg1	discovery					1917:1925	The discovery	1913:1925	The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme,	1913:2044	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	8	14	from	furiosus	1448:1455	arg1	able					1461:1464	able	1461:1464	able	1461:1464	We found that the GH16 endo-β(1,3)-D-glucanase PfLam16A from Pyrococcus furiosus was able to completely and reproducibly degrade β(1,3)-D-glucan without causing the release of other polymers.
34217291	8	14	from	furiosus	1448:1455	arg1	PfLam16A					1423:1430	the GH16 endo-β(1,3)-D-glucanase PfLam16A	1390:1430	the GH16 endo-β(1,3)-D-glucanase PfLam16A from Pyrococcus furiosus	1390:1455	We found that the GH16 endo-β(1,3)-D-glucanase PfLam16A from Pyrococcus furiosus was able to completely and reproducibly degrade β(1,3)-D-glucan without causing the release of other polymers.
34217291	2	15	theme	different	277:285	arg1	functions					287:295	different functions	277:295	different functions	277:295	It is mainly composed of polysaccharides with different functions, some of which are necessary for cell integrity.
34217291	5	16	with	enzymes	879:885	arg1	activities					910:919	non-contaminating activities	892:919	non-contaminating activities	892:919	Nonetheless, for this method to be reliable, the availability of trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities is vital.
34217291	0	17	theme	cell	96:99	arg1	walls					101:105	fungal cell walls	89:105	fungal cell walls	89:105	Analysis and application of a suite of recombinant endo-β(1,3)-D-glucanases for studying fungal cell walls.
34217291	1	18	theme	external	167:174	arg1	structure					176:184	an essential and robust external structure	143:184	an essential and robust external structure that protects the cell from the environment	143:228	BACKGROUND The fungal cell wall is an essential and robust external structure that protects the cell from the environment.
34217291	1	18	theme	external	167:174	arg1	wall					135:138	The fungal cell wall	119:138	The fungal cell wall	119:138	BACKGROUND The fungal cell wall is an essential and robust external structure that protects the cell from the environment.
34217291	9	19	theme	cell	1572:1575	arg1	similar					1617:1623	similar	1617:1623	similar	1617:1623	The cell wall degradation caused by PfLam16A was similar to that of Quantazyme, a recombinant endo-β(1,3)-D-glucanase no longer commercially available.
34217291	9	19	theme	cell	1572:1575	arg1	degradation					1582:1592	The cell wall degradation	1568:1592	The cell wall degradation caused by PfLam16A	1568:1611	The cell wall degradation caused by PfLam16A was similar to that of Quantazyme, a recombinant endo-β(1,3)-D-glucanase no longer commercially available.
34217291	12	20	theme	new	2156:2158	arg1	-D-glucanase					2182:2193	This new commercial endo-β(1,3)-D-glucanase	2151:2193	This new commercial endo-β(1,3)-D-glucanase	2151:2193	This new commercial endo-β(1,3)-D-glucanase will allow the study of the cell wall composition under different conditions, along the cell cycle, in response to environmental changes or in cell wall mutants.
34217291	12	21	theme	cell	2283:2286	arg1	cycle					2288:2292	the cell cycle	2279:2292	the cell cycle	2279:2292	This new commercial endo-β(1,3)-D-glucanase will allow the study of the cell wall composition under different conditions, along the cell cycle, in response to environmental changes or in cell wall mutants.
34217291	12	22	theme	1,3	2178:2180	arg1	-D-glucanase					2182:2193	This new commercial endo-β(1,3)-D-glucanase	2151:2193	This new commercial endo-β(1,3)-D-glucanase	2151:2193	This new commercial endo-β(1,3)-D-glucanase will allow the study of the cell wall composition under different conditions, along the cell cycle, in response to environmental changes or in cell wall mutants.
34217291	11	23	theme	efficient	1945:1953	arg1	-D-glucanase					1978:1989	a reliable and efficient recombinant endo-β(1,3)-D-glucanase	1930:1989	a reliable and efficient recombinant endo-β(1,3)-D-glucanase	1930:1989	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	12	24	theme	endo-β	2171:2176	arg1	-D-glucanase					2182:2193	This new commercial endo-β(1,3)-D-glucanase	2151:2193	This new commercial endo-β(1,3)-D-glucanase	2151:2193	This new commercial endo-β(1,3)-D-glucanase will allow the study of the cell wall composition under different conditions, along the cell cycle, in response to environmental changes or in cell wall mutants.
34217291	7	25	theme	main	1292:1295	arg1	-D-glucan					1345:1353	β(1,3)-D-glucan	1339:1353	β(1,3)-D-glucan	1339:1353	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	7	25	theme	main	1292:1295	arg1	polymers					1297:1304	the four main polymers	1283:1304	the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan	1283:1373	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	7	25	theme	main	1292:1295	arg1	galactomannoproteins					1307:1326	galactomannoproteins	1307:1326	galactomannoproteins	1307:1326	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	7	25	theme	main	1292:1295	arg1	α-glucan					1329:1336	α-glucan	1329:1336	α-glucan	1329:1336	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	7	25	theme	main	1292:1295	arg1	-D-glucan					1365:1373	β(1,6)-D-glucan	1359:1373	β(1,6)-D-glucan	1359:1373	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	13	26	theme	wall	2664:2667	arg1	synthesis					2669:2677	cell wall synthesis	2659:2677	cell wall synthesis	2659:2677	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	5	27	theme	recombinant	847:857	arg1	enzymes					879:885	trustworthy commercial recombinant cell wall degrading enzymes	824:885	trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities	824:919	Nonetheless, for this method to be reliable, the availability of trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities is vital.
34217291	11	28	theme	reliable	1932:1939	arg1	-D-glucanase					1978:1989	a reliable and efficient recombinant endo-β(1,3)-D-glucanase	1930:1989	a reliable and efficient recombinant endo-β(1,3)-D-glucanase	1930:1989	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	6	29	theme	fractionation	1132:1144	arg1	protocol					1120:1127	a fast and reliable protocol	1100:1127	a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall	1100:1188	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	13	30	theme	new	2618:2620	arg1	antifungals					2622:2632	new antifungals	2618:2632	new antifungals that specifically target cell wall synthesis	2618:2677	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	5	31	theme	wall	864:867	arg1	enzymes					879:885	trustworthy commercial recombinant cell wall degrading enzymes	824:885	trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities	824:919	Nonetheless, for this method to be reliable, the availability of trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities is vital.
34217291	7	32	theme	chemical	1228:1235	arg1	degradation					1237:1247	enzymatic and chemical degradation	1214:1247	enzymatic and chemical degradation	1214:1247	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	0	33	theme	endo-β	51:56	arg1	suite					30:34	a suite	28:34	a suite of recombinant endo-β(1,3)	28:61	Analysis and application of a suite of recombinant endo-β(1,3)-D-glucanases for studying fungal cell walls.
34217291	3	34	theme	applications	561:572	arg1	applications					561:572	practical and commercial applications	536:572	practical and commercial applications	536:572	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	3	34	theme	applications	561:572	arg1	variety					525:531	a variety	523:531	a variety of practical and commercial applications	523:572	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	1	35	theme	fungal	123:128	arg1	structure					176:184	an essential and robust external structure	143:184	an essential and robust external structure that protects the cell from the environment	143:228	BACKGROUND The fungal cell wall is an essential and robust external structure that protects the cell from the environment.
34217291	1	35	theme	fungal	123:128	arg1	wall					135:138	The fungal cell wall	119:138	The fungal cell wall	119:138	BACKGROUND The fungal cell wall is an essential and robust external structure that protects the cell from the environment.
34217291	5	36	theme	trustworthy	824:834	arg1	enzymes					879:885	trustworthy commercial recombinant cell wall degrading enzymes	824:885	trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities	824:919	Nonetheless, for this method to be reliable, the availability of trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities is vital.
34217291	2	37	with	polysaccharides	256:270	arg1	functions					287:295	different functions	277:295	different functions	277:295	It is mainly composed of polysaccharides with different functions, some of which are necessary for cell integrity.
34217291	10	38	theme	polysaccharides	1884:1898	arg1	release					1867:1873	release	1867:1873	release of other polysaccharides	1867:1898	Moreover, other recombinant β(1,3)-D-glucanases caused either incomplete or excessive degradation, suggesting deficient access to the substrate or release of other polysaccharides.
34217291	10	38	theme	polysaccharides	1884:1898	arg1	access					1840:1845	deficient access	1830:1845	deficient access to the substrate	1830:1862	Moreover, other recombinant β(1,3)-D-glucanases caused either incomplete or excessive degradation, suggesting deficient access to the substrate or release of other polysaccharides.
34217291	4	39	dep	cell	637:640	arg1	morphogenesis					642:654	morphogenesis	642:654	morphogenesis	642:654	This method can be used to study the mechanisms that regulate cell morphogenesis and integrity, giving rise to information that could be applied in the design of new antifungal drugs.
34217291	13	40	theme	practical	2422:2430	arg1	fusion					2557:2562	cell fusion	2552:2562	cell fusion	2552:2562	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	40	theme	practical	2422:2430	arg1	processes					2593:2601	industrial processes	2582:2601	industrial processes	2582:2601	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	40	theme	practical	2422:2430	arg1	research					2475:2482	genome research	2468:2482	genome research	2468:2482	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	40	theme	practical	2422:2430	arg1	transformation					2514:2527	cell transformation	2509:2527	cell transformation	2509:2527	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	40	theme	practical	2422:2430	arg1	studies					2607:2613	studies	2607:2613	studies of new antifungals that specifically target cell wall synthesis	2607:2677	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	40	theme	practical	2422:2430	arg1	formation					2541:2549	protoplast formation	2530:2549	protoplast formation	2530:2549	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	40	theme	practical	2422:2430	arg1	applications					2447:2458	other practical and commercial applications	2416:2458	other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis	2416:2677	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	40	theme	practical	2422:2430	arg1	disruption					2570:2579	cell disruption	2565:2579	cell disruption	2565:2579	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	40	theme	practical	2422:2430	arg1	extraction					2497:2506	chromosomes extraction	2485:2506	chromosomes extraction	2485:2506	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	41	theme	cell	2565:2568	arg1	disruption					2570:2579	cell disruption	2565:2579	cell disruption	2565:2579	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	3	42	dep	function	450:457	arg1	the					446:448	the	446:448	the	446:448	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	7	43	theme	cell	1268:1271	arg1	wall					1273:1276	the cell wall	1264:1276	the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan	1264:1373	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	9	44	theme	recombinant	1650:1660	arg1	-D-glucanase					1673:1684	a recombinant endo-β(1,3)-D-glucanase	1648:1684	a recombinant endo-β(1,3)-D-glucanase no longer commercially available	1648:1717	The cell wall degradation caused by PfLam16A was similar to that of Quantazyme, a recombinant endo-β(1,3)-D-glucanase no longer commercially available.
34217291	9	44	theme	recombinant	1650:1660	arg1	Quantazyme					1636:1645	Quantazyme	1636:1645	Quantazyme	1636:1645	The cell wall degradation caused by PfLam16A was similar to that of Quantazyme, a recombinant endo-β(1,3)-D-glucanase no longer commercially available.
34217291	5	45	theme	enzymes	879:885	arg1	vital					924:928	vital	924:928	vital	924:928	Nonetheless, for this method to be reliable, the availability of trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities is vital.
34217291	5	45	theme	enzymes	879:885	arg1	availability					808:819	the availability	804:819	the availability of trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities	804:919	Nonetheless, for this method to be reliable, the availability of trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities is vital.
34217291	8	46	theme	-D-glucanase	1410:1421	arg1	able					1461:1464	able	1461:1464	able	1461:1464	We found that the GH16 endo-β(1,3)-D-glucanase PfLam16A from Pyrococcus furiosus was able to completely and reproducibly degrade β(1,3)-D-glucan without causing the release of other polymers.
34217291	8	46	theme	-D-glucanase	1410:1421	arg1	PfLam16A					1423:1430	the GH16 endo-β(1,3)-D-glucanase PfLam16A	1390:1430	the GH16 endo-β(1,3)-D-glucanase PfLam16A from Pyrococcus furiosus	1390:1455	We found that the GH16 endo-β(1,3)-D-glucanase PfLam16A from Pyrococcus furiosus was able to completely and reproducibly degrade β(1,3)-D-glucan without causing the release of other polymers.
34217291	13	47	theme	antifungals	2622:2632	arg1	fusion					2557:2562	cell fusion	2552:2562	cell fusion	2552:2562	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	47	theme	antifungals	2622:2632	arg1	processes					2593:2601	industrial processes	2582:2601	industrial processes	2582:2601	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	47	theme	antifungals	2622:2632	arg1	research					2475:2482	genome research	2468:2482	genome research	2468:2482	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	47	theme	antifungals	2622:2632	arg1	transformation					2514:2527	cell transformation	2509:2527	cell transformation	2509:2527	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	47	theme	antifungals	2622:2632	arg1	studies					2607:2613	studies	2607:2613	studies of new antifungals that specifically target cell wall synthesis	2607:2677	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	47	theme	antifungals	2622:2632	arg1	formation					2541:2549	protoplast formation	2530:2549	protoplast formation	2530:2549	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	47	theme	antifungals	2622:2632	arg1	disruption					2570:2579	cell disruption	2565:2579	cell disruption	2565:2579	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	47	theme	antifungals	2622:2632	arg1	extraction					2497:2506	chromosomes extraction	2485:2506	chromosomes extraction	2485:2506	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	5	48	theme	non-contaminating	892:908	arg1	activities					910:919	non-contaminating activities	892:919	non-contaminating activities	892:919	Nonetheless, for this method to be reliable, the availability of trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities is vital.
34217291	6	49	theme	recombinant	997:1007	arg1	-D-glucanases					1020:1032	12 recombinant endo-β(1,3)-D-glucanases	994:1032	12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan	994:1089	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	4	50	theme	drugs	752:756	arg1	design					727:732	the design	723:732	the design of new antifungal drugs	723:756	This method can be used to study the mechanisms that regulate cell morphogenesis and integrity, giving rise to information that could be applied in the design of new antifungal drugs.
34217291	3	51	theme	wall	402:405	arg1	polysaccharides					407:421	cell wall polysaccharides	397:421	cell wall polysaccharides	397:421	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	13	52	theme	commercial	2436:2445	arg1	fusion					2557:2562	cell fusion	2552:2562	cell fusion	2552:2562	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	52	theme	commercial	2436:2445	arg1	processes					2593:2601	industrial processes	2582:2601	industrial processes	2582:2601	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	52	theme	commercial	2436:2445	arg1	research					2475:2482	genome research	2468:2482	genome research	2468:2482	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	52	theme	commercial	2436:2445	arg1	transformation					2514:2527	cell transformation	2509:2527	cell transformation	2509:2527	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	52	theme	commercial	2436:2445	arg1	studies					2607:2613	studies	2607:2613	studies of new antifungals that specifically target cell wall synthesis	2607:2677	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	52	theme	commercial	2436:2445	arg1	formation					2541:2549	protoplast formation	2530:2549	protoplast formation	2530:2549	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	52	theme	commercial	2436:2445	arg1	applications					2447:2458	other practical and commercial applications	2416:2458	other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis	2416:2677	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	52	theme	commercial	2436:2445	arg1	disruption					2570:2579	cell disruption	2565:2579	cell disruption	2565:2579	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	52	theme	commercial	2436:2445	arg1	extraction					2497:2506	chromosomes extraction	2485:2506	chromosomes extraction	2485:2506	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	6	53	theme	β	1075:1075	arg1	-D-glucan					1081:1089	the cell wall β(1,3)-D-glucan	1061:1089	the cell wall β(1,3)-D-glucan	1061:1089	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	12	54	theme	wall	2343:2346	arg1	mutants					2348:2354	cell wall mutants	2338:2354	cell wall mutants	2338:2354	This new commercial endo-β(1,3)-D-glucanase will allow the study of the cell wall composition under different conditions, along the cell cycle, in response to environmental changes or in cell wall mutants.
34217291	12	55	theme	wall	2228:2231	arg1	composition					2233:2243	the cell wall composition	2219:2243	the cell wall composition	2219:2243	This new commercial endo-β(1,3)-D-glucanase will allow the study of the cell wall composition under different conditions, along the cell cycle, in response to environmental changes or in cell wall mutants.
34217291	10	56	theme	recombinant	1736:1746	arg1	1,3					1750:1752	1,3	1750:1752	1,3	1750:1752	Moreover, other recombinant β(1,3)-D-glucanases caused either incomplete or excessive degradation, suggesting deficient access to the substrate or release of other polysaccharides.
34217291	10	56	theme	recombinant	1736:1746	arg1	β					1748:1748	other recombinant β	1730:1748	other recombinant β(1,3)	1730:1753	Moreover, other recombinant β(1,3)-D-glucanases caused either incomplete or excessive degradation, suggesting deficient access to the substrate or release of other polysaccharides.
34217291	13	57	theme	cell	2552:2555	arg1	fusion					2557:2562	cell fusion	2552:2562	cell fusion	2552:2562	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	6	58	theme	cell	1065:1068	arg1	-D-glucan					1081:1089	the cell wall β(1,3)-D-glucan	1061:1089	the cell wall β(1,3)-D-glucan	1061:1089	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	4	59	theme	new	737:739	arg1	drugs					752:756	new antifungal drugs	737:756	new antifungal drugs	737:756	This method can be used to study the mechanisms that regulate cell morphogenesis and integrity, giving rise to information that could be applied in the design of new antifungal drugs.
34217291	2	60	theme	cell	330:333	arg1	integrity					335:343	cell integrity	330:343	cell integrity	330:343	It is mainly composed of polysaccharides with different functions, some of which are necessary for cell integrity.
34217291	3	61	dep	useful	426:431	arg1	process					356:362	the process	352:362	the process of fractionation and analysis of cell wall polysaccharides	352:421	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	3	61	dep	useful	426:431	arg1	developing					512:521	developing	512:521	developing a variety of practical and commercial applications	512:572	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	3	61	dep	useful	426:431	arg1	studying					437:444	studying	437:444	studying the function and relevance of each polysaccharide	437:494	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	3	61	dep	useful	426:431	arg1	useful					426:431	useful	426:431	useful	426:431	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	8	62	theme	β	1505:1505	arg1	-D-glucan					1511:1519	β(1,3)-D-glucan	1505:1519	β(1,3)-D-glucan	1505:1519	We found that the GH16 endo-β(1,3)-D-glucanase PfLam16A from Pyrococcus furiosus was able to completely and reproducibly degrade β(1,3)-D-glucan without causing the release of other polymers.
34217291	8	63	theme	other	1552:1556	arg1	polymers					1558:1565	other polymers	1552:1565	other polymers	1552:1565	We found that the GH16 endo-β(1,3)-D-glucanase PfLam16A from Pyrococcus furiosus was able to completely and reproducibly degrade β(1,3)-D-glucan without causing the release of other polymers.
34217291	6	64	theme	fast	1102:1105	arg1	protocol					1120:1127	a fast and reliable protocol	1100:1127	a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall	1100:1188	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	11	65	theme	fungal	2117:2122	arg1	wall					2129:2132	the fungal cell wall	2113:2132	the fungal cell wall β(1,3)-D-glucan	2113:2148	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	8	66	theme	1,3	1507:1509	arg1	-D-glucan					1511:1519	β(1,3)-D-glucan	1505:1519	β(1,3)-D-glucan	1505:1519	We found that the GH16 endo-β(1,3)-D-glucanase PfLam16A from Pyrococcus furiosus was able to completely and reproducibly degrade β(1,3)-D-glucan without causing the release of other polymers.
34217291	10	67	theme	incomplete	1782:1791	arg1	degradation					1806:1816	either incomplete or excessive degradation	1775:1816	either incomplete or excessive degradation	1775:1816	Moreover, other recombinant β(1,3)-D-glucanases caused either incomplete or excessive degradation, suggesting deficient access to the substrate or release of other polysaccharides.
34217291	6	68	theme	wall	1185:1188	arg1	analysis					1150:1157	analysis	1150:1157	analysis of the fission yeast cell wall	1150:1188	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	6	68	theme	wall	1185:1188	arg1	fractionation					1132:1144	fractionation	1132:1144	fractionation	1132:1144	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	3	69	theme	polysaccharide	481:494	arg1	relevance					463:471	relevance	463:471	relevance	463:471	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	3	69	theme	polysaccharide	481:494	arg1	function					450:457	function	450:457	function	450:457	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	7	70	theme	1,3	1341:1343	arg1	polymers					1297:1304	the four main polymers	1283:1304	the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan	1283:1373	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	7	70	theme	1,3	1341:1343	arg1	-D-glucan					1345:1353	β(1,3)-D-glucan	1339:1353	β(1,3)-D-glucan	1339:1353	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	12	71	theme	composition	2233:2243	arg1	study					2210:2214	the study	2206:2214	the study of the cell wall composition	2206:2243	This new commercial endo-β(1,3)-D-glucanase will allow the study of the cell wall composition under different conditions, along the cell cycle, in response to environmental changes or in cell wall mutants.
34217291	6	72	theme	yeast	1174:1178	arg1	wall					1185:1188	the fission yeast cell wall	1162:1188	the fission yeast cell wall	1162:1188	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	13	73	theme	cell	2509:2512	arg1	transformation					2514:2527	cell transformation	2509:2527	cell transformation	2509:2527	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	1	74	theme	essential	146:154	arg1	structure					176:184	an essential and robust external structure	143:184	an essential and robust external structure that protects the cell from the environment	143:228	BACKGROUND The fungal cell wall is an essential and robust external structure that protects the cell from the environment.
34217291	1	74	theme	essential	146:154	arg1	wall					135:138	The fungal cell wall	119:138	The fungal cell wall	119:138	BACKGROUND The fungal cell wall is an essential and robust external structure that protects the cell from the environment.
34217291	6	75	theme	fission	1166:1172	arg1	wall					1185:1188	the fission yeast cell wall	1162:1188	the fission yeast cell wall	1162:1188	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	7	76	theme	β	1339:1339	arg1	polymers					1297:1304	the four main polymers	1283:1304	the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan	1283:1373	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	7	76	theme	β	1339:1339	arg1	-D-glucan					1345:1353	β(1,3)-D-glucan	1339:1353	β(1,3)-D-glucan	1339:1353	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	13	77	theme	genome	2468:2473	arg1	research					2475:2482	genome research	2468:2482	genome research	2468:2482	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	1	78	theme	robust	160:165	arg1	structure					176:184	an essential and robust external structure	143:184	an essential and robust external structure that protects the cell from the environment	143:228	BACKGROUND The fungal cell wall is an essential and robust external structure that protects the cell from the environment.
34217291	1	78	theme	robust	160:165	arg1	wall					135:138	The fungal cell wall	119:138	The fungal cell wall	119:138	BACKGROUND The fungal cell wall is an essential and robust external structure that protects the cell from the environment.
34217291	12	79	theme	commercial	2160:2169	arg1	-D-glucanase					2182:2193	This new commercial endo-β(1,3)-D-glucanase	2151:2193	This new commercial endo-β(1,3)-D-glucanase	2151:2193	This new commercial endo-β(1,3)-D-glucanase will allow the study of the cell wall composition under different conditions, along the cell cycle, in response to environmental changes or in cell wall mutants.
34217291	6	80	theme	1,3	1077:1079	arg1	-D-glucan					1081:1089	the cell wall β(1,3)-D-glucan	1061:1089	the cell wall β(1,3)-D-glucan	1061:1089	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	11	81	theme	wall	2129:2132	arg1	digestion					2100:2108	the digestion	2096:2108	the digestion of the fungal cell wall β(1,3)-D-glucan	2096:2148	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	10	82	theme	excessive	1796:1804	arg1	degradation					1806:1816	either incomplete or excessive degradation	1775:1816	either incomplete or excessive degradation	1775:1816	Moreover, other recombinant β(1,3)-D-glucanases caused either incomplete or excessive degradation, suggesting deficient access to the substrate or release of other polysaccharides.
34217291	3	83	theme	practical	536:544	arg1	applications					561:572	practical and commercial applications	536:572	practical and commercial applications	536:572	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	9	84	theme	wall	1577:1580	arg1	similar					1617:1623	similar	1617:1623	similar	1617:1623	The cell wall degradation caused by PfLam16A was similar to that of Quantazyme, a recombinant endo-β(1,3)-D-glucanase no longer commercially available.
34217291	9	84	theme	wall	1577:1580	arg1	degradation					1582:1592	The cell wall degradation	1568:1592	The cell wall degradation caused by PfLam16A	1568:1611	The cell wall degradation caused by PfLam16A was similar to that of Quantazyme, a recombinant endo-β(1,3)-D-glucanase no longer commercially available.
34217291	13	85	theme	cell	2659:2662	arg1	synthesis					2669:2677	cell wall synthesis	2659:2677	cell wall synthesis	2659:2677	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	5	86	theme	commercial	836:845	arg1	enzymes					879:885	trustworthy commercial recombinant cell wall degrading enzymes	824:885	trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities	824:919	Nonetheless, for this method to be reliable, the availability of trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities is vital.
34217291	11	87	theme	recombinant	1955:1965	arg1	1,3					1974:1976	1,3	1974:1976	1,3	1974:1976	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	11	87	theme	recombinant	1955:1965	arg1	endo-β					1967:1972	recombinant endo-β	1955:1972	a reliable and efficient recombinant endo-β(1,3)-D-glucanase	1930:1989	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	10	88	theme	deficient	1830:1838	arg1	access					1840:1845	deficient access	1830:1845	deficient access to the substrate	1830:1862	Moreover, other recombinant β(1,3)-D-glucanases caused either incomplete or excessive degradation, suggesting deficient access to the substrate or release of other polysaccharides.
34217291	5	89	theme	cell	859:862	arg1	enzymes					879:885	trustworthy commercial recombinant cell wall degrading enzymes	824:885	trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities	824:919	Nonetheless, for this method to be reliable, the availability of trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities is vital.
34217291	3	90	theme	commercial	550:559	arg1	applications					561:572	practical and commercial applications	536:572	practical and commercial applications	536:572	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	4	91	used	used	594:597	arg2	method					580:585	This method	575:585	This method	575:585	This method can be used to study the mechanisms that regulate cell morphogenesis and integrity, giving rise to information that could be applied in the design of new antifungal drugs.
34217291	12	92	theme	cell	2338:2341	arg1	mutants					2348:2354	cell wall mutants	2338:2354	cell wall mutants	2338:2354	This new commercial endo-β(1,3)-D-glucanase will allow the study of the cell wall composition under different conditions, along the cell cycle, in response to environmental changes or in cell wall mutants.
34217291	13	93	theme	other	2416:2420	arg1	fusion					2557:2562	cell fusion	2552:2562	cell fusion	2552:2562	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	93	theme	other	2416:2420	arg1	processes					2593:2601	industrial processes	2582:2601	industrial processes	2582:2601	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	93	theme	other	2416:2420	arg1	research					2475:2482	genome research	2468:2482	genome research	2468:2482	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	93	theme	other	2416:2420	arg1	transformation					2514:2527	cell transformation	2509:2527	cell transformation	2509:2527	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	93	theme	other	2416:2420	arg1	studies					2607:2613	studies	2607:2613	studies of new antifungals that specifically target cell wall synthesis	2607:2677	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	93	theme	other	2416:2420	arg1	formation					2541:2549	protoplast formation	2530:2549	protoplast formation	2530:2549	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	93	theme	other	2416:2420	arg1	applications					2447:2458	other practical and commercial applications	2416:2458	other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis	2416:2677	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	93	theme	other	2416:2420	arg1	disruption					2570:2579	cell disruption	2565:2579	cell disruption	2565:2579	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	13	93	theme	other	2416:2420	arg1	extraction					2497:2506	chromosomes extraction	2485:2506	chromosomes extraction	2485:2506	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	6	94	theme	reliable	1111:1118	arg1	protocol					1120:1127	a fast and reliable protocol	1100:1127	a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall	1100:1188	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	1	95	theme	cell	130:133	arg1	structure					176:184	an essential and robust external structure	143:184	an essential and robust external structure that protects the cell from the environment	143:228	BACKGROUND The fungal cell wall is an essential and robust external structure that protects the cell from the environment.
34217291	1	95	theme	cell	130:133	arg1	wall					135:138	The fungal cell wall	119:138	The fungal cell wall	119:138	BACKGROUND The fungal cell wall is an essential and robust external structure that protects the cell from the environment.
34217291	6	96	dep	efficiency	960:969	arg1	the					956:958	the	956:958	the	956:958	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	1	97	dep	BACKGROUND	108:117	arg1	structure					176:184	an essential and robust external structure	143:184	an essential and robust external structure that protects the cell from the environment	143:228	BACKGROUND The fungal cell wall is an essential and robust external structure that protects the cell from the environment.
34217291	1	97	dep	BACKGROUND	108:117	arg1	wall					135:138	The fungal cell wall	119:138	The fungal cell wall	119:138	BACKGROUND The fungal cell wall is an essential and robust external structure that protects the cell from the environment.
34217291	10	98	theme	other	1878:1882	arg1	polysaccharides					1884:1898	other polysaccharides	1878:1898	other polysaccharides	1878:1898	Moreover, other recombinant β(1,3)-D-glucanases caused either incomplete or excessive degradation, suggesting deficient access to the substrate or release of other polysaccharides.
34217291	0	99	theme	fungal	89:94	arg1	walls					101:105	fungal cell walls	89:105	fungal cell walls	89:105	Analysis and application of a suite of recombinant endo-β(1,3)-D-glucanases for studying fungal cell walls.
34217291	6	100	theme	-D-glucanases	1020:1032	arg1	efficiency					960:969	efficiency	960:969	efficiency	960:969	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	6	100	theme	-D-glucanases	1020:1032	arg1	reproducibility					975:989	reproducibility	975:989	reproducibility	975:989	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	3	101	theme	cell	397:400	arg1	polysaccharides					407:421	cell wall polysaccharides	397:421	cell wall polysaccharides	397:421	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	5	102	theme	degrading	869:877	arg1	enzymes					879:885	trustworthy commercial recombinant cell wall degrading enzymes	824:885	trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities	824:919	Nonetheless, for this method to be reliable, the availability of trustworthy commercial recombinant cell wall degrading enzymes with non-contaminating activities is vital.
34217291	9	103	theme	endo-β	1662:1667	arg1	-D-glucanase					1673:1684	a recombinant endo-β(1,3)-D-glucanase	1648:1684	a recombinant endo-β(1,3)-D-glucanase no longer commercially available	1648:1717	The cell wall degradation caused by PfLam16A was similar to that of Quantazyme, a recombinant endo-β(1,3)-D-glucanase no longer commercially available.
34217291	9	103	theme	endo-β	1662:1667	arg1	Quantazyme					1636:1645	Quantazyme	1636:1645	Quantazyme	1636:1645	The cell wall degradation caused by PfLam16A was similar to that of Quantazyme, a recombinant endo-β(1,3)-D-glucanase no longer commercially available.
34217291	12	104	theme	different	2251:2259	arg1	conditions					2261:2270	different conditions	2251:2270	different conditions	2251:2270	This new commercial endo-β(1,3)-D-glucanase will allow the study of the cell wall composition under different conditions, along the cell cycle, in response to environmental changes or in cell wall mutants.
34217291	3	105	theme	analysis	385:392	arg1	process					356:362	the process	352:362	the process of fractionation and analysis of cell wall polysaccharides	352:421	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	3	105	theme	analysis	385:392	arg1	developing					512:521	developing	512:521	developing a variety of practical and commercial applications	512:572	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	3	105	theme	analysis	385:392	arg1	studying					437:444	studying	437:444	studying the function and relevance of each polysaccharide	437:494	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	3	105	theme	analysis	385:392	arg1	useful					426:431	useful	426:431	useful	426:431	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	13	106	theme	industrial	2582:2591	arg1	processes					2593:2601	industrial processes	2582:2601	industrial processes	2582:2601	Furthermore, this enzyme will also be greatly valuable for other practical and commercial applications such as genome research, chromosomes extraction, cell transformation, protoplast formation, cell fusion, cell disruption, industrial processes and studies of new antifungals that specifically target cell wall synthesis.
34217291	6	107	theme	endo-β	1009:1014	arg1	-D-glucanases					1020:1032	12 recombinant endo-β(1,3)-D-glucanases	994:1032	12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan	994:1089	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	9	108	theme	1,3	1669:1671	arg1	-D-glucanase					1673:1684	a recombinant endo-β(1,3)-D-glucanase	1648:1684	a recombinant endo-β(1,3)-D-glucanase no longer commercially available	1648:1717	The cell wall degradation caused by PfLam16A was similar to that of Quantazyme, a recombinant endo-β(1,3)-D-glucanase no longer commercially available.
34217291	9	108	theme	1,3	1669:1671	arg1	Quantazyme					1636:1645	Quantazyme	1636:1645	Quantazyme	1636:1645	The cell wall degradation caused by PfLam16A was similar to that of Quantazyme, a recombinant endo-β(1,3)-D-glucanase no longer commercially available.
34217291	8	109	theme	Pyrococcus	1437:1446	arg1	furiosus					1448:1455	Pyrococcus furiosus	1437:1455	Pyrococcus furiosus	1437:1455	We found that the GH16 endo-β(1,3)-D-glucanase PfLam16A from Pyrococcus furiosus was able to completely and reproducibly degrade β(1,3)-D-glucan without causing the release of other polymers.
34217291	11	110	dep	CONCLUSIONS	1901:1911	arg1	useful					2054:2059	useful	2054:2059	useful	2054:2059	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	11	110	dep	CONCLUSIONS	1901:1911	arg1	discovery					1917:1925	The discovery	1913:1925	The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme,	1913:2044	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
34217291	0	111	theme	suite	30:34	arg1	application					13:23	application	13:23	application	13:23	Analysis and application of a suite of recombinant endo-β(1,3)-D-glucanases for studying fungal cell walls.
34217291	0	111	theme	suite	30:34	arg1	Analysis					0:7	Analysis	0:7	Analysis	0:7	Analysis and application of a suite of recombinant endo-β(1,3)-D-glucanases for studying fungal cell walls.
34217291	7	112	theme	enzymatic	1214:1222	arg1	degradation					1237:1247	enzymatic and chemical degradation	1214:1247	enzymatic and chemical degradation	1214:1247	This protocol combines enzymatic and chemical degradation to fractionate the cell wall into the four main polymers: galactomannoproteins, α-glucan, β(1,3)-D-glucan and β(1,6)-D-glucan.
34217291	3	113	theme	fractionation	367:379	arg1	process					356:362	the process	352:362	the process of fractionation and analysis of cell wall polysaccharides	352:421	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	3	113	theme	fractionation	367:379	arg1	developing					512:521	developing	512:521	developing a variety of practical and commercial applications	512:572	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	3	113	theme	fractionation	367:379	arg1	studying					437:444	studying	437:444	studying the function and relevance of each polysaccharide	437:494	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	3	113	theme	fractionation	367:379	arg1	useful					426:431	useful	426:431	useful	426:431	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	12	114	theme	cell	2223:2226	arg1	composition					2233:2243	the cell wall composition	2219:2243	the cell wall composition	2219:2243	This new commercial endo-β(1,3)-D-glucanase will allow the study of the cell wall composition under different conditions, along the cell cycle, in response to environmental changes or in cell wall mutants.
34217291	4	115	theme	antifungal	741:750	arg1	drugs					752:756	new antifungal drugs	737:756	new antifungal drugs	737:756	This method can be used to study the mechanisms that regulate cell morphogenesis and integrity, giving rise to information that could be applied in the design of new antifungal drugs.
34217291	3	116	theme	polysaccharides	407:421	arg1	analysis					385:392	analysis	385:392	analysis	385:392	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	3	116	theme	polysaccharides	407:421	arg1	fractionation					367:379	fractionation	367:379	fractionation	367:379	Thus, the process of fractionation and analysis of cell wall polysaccharides is useful for studying the function and relevance of each polysaccharide, as well as for developing a variety of practical and commercial applications.
34217291	0	117	theme	recombinant	39:49	arg1	1,3					58:60	1,3	58:60	1,3	58:60	Analysis and application of a suite of recombinant endo-β(1,3)-D-glucanases for studying fungal cell walls.
34217291	0	117	theme	recombinant	39:49	arg1	endo-β					51:56	recombinant endo-β	39:56	recombinant endo-β(1,3)	39:61	Analysis and application of a suite of recombinant endo-β(1,3)-D-glucanases for studying fungal cell walls.
34217291	10	118	dep	-D-glucanases	1754:1766	arg1	caused					1768:1773	caused	1768:1773	caused either incomplete or excessive degradation	1768:1816	Moreover, other recombinant β(1,3)-D-glucanases caused either incomplete or excessive degradation, suggesting deficient access to the substrate or release of other polysaccharides.
34217291	6	119	theme	wall	1070:1073	arg1	-D-glucan					1081:1089	the cell wall β(1,3)-D-glucan	1061:1089	the cell wall β(1,3)-D-glucan	1061:1089	RESULTS Here we examined the efficiency and reproducibility of 12 recombinant endo-β(1,3)-D-glucanases for specifically degrading the cell wall β(1,3)-D-glucan by using a fast and reliable protocol of fractionation and analysis of the fission yeast cell wall.
34217291	9	120	theme	available	1709:1717	arg1	-D-glucanase					1673:1684	a recombinant endo-β(1,3)-D-glucanase	1648:1684	a recombinant endo-β(1,3)-D-glucanase no longer commercially available	1648:1717	The cell wall degradation caused by PfLam16A was similar to that of Quantazyme, a recombinant endo-β(1,3)-D-glucanase no longer commercially available.
34217291	9	120	theme	available	1709:1717	arg1	Quantazyme					1636:1645	Quantazyme	1636:1645	Quantazyme	1636:1645	The cell wall degradation caused by PfLam16A was similar to that of Quantazyme, a recombinant endo-β(1,3)-D-glucanase no longer commercially available.
34217291	10	121	theme	other	1730:1734	arg1	1,3					1750:1752	1,3	1750:1752	1,3	1750:1752	Moreover, other recombinant β(1,3)-D-glucanases caused either incomplete or excessive degradation, suggesting deficient access to the substrate or release of other polysaccharides.
34217291	10	121	theme	other	1730:1734	arg1	β					1748:1748	other recombinant β	1730:1748	other recombinant β(1,3)	1730:1753	Moreover, other recombinant β(1,3)-D-glucanases caused either incomplete or excessive degradation, suggesting deficient access to the substrate or release of other polysaccharides.
34217291	11	122	theme	-D-glucan	2140:2148	arg1	wall					2129:2132	the fungal cell wall	2113:2132	the fungal cell wall β(1,3)-D-glucan	2113:2148	CONCLUSIONS The discovery of a reliable and efficient recombinant endo-β(1,3)-D-glucanase, capable of replacing the previously mentioned enzyme, will be useful for carrying out studies requiring the digestion of the fungal cell wall β(1,3)-D-glucan.
32623912	6	0	dep	RESULTS	955:961	arg1	confirmed					1048:1056	confirmed	1048:1056	confirmed the thiolation process	1048:1079	RESULTS The results of the characterization of prepared sodium alginate l-cysteine conjugate confirmed the thiolation process.
32623912	1	1	from	optimization	300:311	arg1	permeation					380:389	permeation	380:389	permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation	380:477	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	0	2	from	TDDS	141:144	arg1	drug					131:134	BCS class III drug	117:134	BCS class III drug from TDDS	117:144	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	0	2	from	TDDS	141:144	arg1	activity					105:112	the permeation enhancing activity	80:112	the permeation enhancing activity of BCS class III drug from TDDS	80:144	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	10	3	theme	ropinirole	1586:1595	arg1	permeation					1611:1620	ropinirole hydrochloride permeation	1586:1620	ropinirole hydrochloride permeation	1586:1620	The increased target flux and maximum drug permeation from an optimized patch suggested that there was an effect of SACC on ropinirole hydrochloride permeation in the presence of IPM as a permeation enhancer.
32623912	0	4	theme	composite	171:179	arg1	design					181:186	central composite design	163:186	central composite design	163:186	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	1	5	theme	transdermal	455:465	arg1	formulation					467:477	the transdermal formulation	451:477	the transdermal formulation	451:477	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	1	6	theme	research	263:270	arg1	objective					238:246	The objective	234:246	The objective of the present research	234:270	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	10	7	theme	SACC	1578:1581	arg1	effect					1568:1573	an effect	1565:1573	an effect of SACC on ropinirole hydrochloride permeation	1565:1620	The increased target flux and maximum drug permeation from an optimized patch suggested that there was an effect of SACC on ropinirole hydrochloride permeation in the presence of IPM as a permeation enhancer.
32623912	9	8	theme	design	1269:1274	arg1	space					1276:1280	the design space	1265:1280	the design space	1265:1280	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	6	9	theme	alginate	1018:1025	arg1	conjugate					1038:1046	prepared sodium alginate l-cysteine conjugate	1002:1046	prepared sodium alginate l-cysteine conjugate	1002:1046	RESULTS The results of the characterization of prepared sodium alginate l-cysteine conjugate confirmed the thiolation process.
32623912	0	10	theme	BCS	117:119	arg1	class					121:125	BCS class III	117:129	BCS class III drug from TDDS	117:144	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	9	11	theme	optimized	1287:1295	arg1	formulation					1297:1307	the optimized formulation	1283:1307	the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight	1283:1383	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	6	12	theme	prepared	1002:1009	arg1	conjugate					1038:1046	prepared sodium alginate l-cysteine conjugate	1002:1046	prepared sodium alginate l-cysteine conjugate	1002:1046	RESULTS The results of the characterization of prepared sodium alginate l-cysteine conjugate confirmed the thiolation process.
32623912	9	13	theme	maximum	1437:1443	arg1	permeation					1450:1459	maximum drug permeation	1437:1459	maximum drug permeation	1437:1459	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	1	14	theme	high	394:397	arg1	hydrochloride					432:444	high soluble low permeable ropinirole hydrochloride	394:444	high soluble low permeable ropinirole hydrochloride from the transdermal formulation	394:477	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	7	15	theme	Stability	1082:1090	arg1	studies					1092:1098	Stability studies	1082:1098	Stability studies	1082:1098	Stability studies suggested that the drug was compatible with all the excipients.
32623912	6	16	theme	characterization	982:997	arg1	results					967:973	The results	963:973	The results of the characterization of prepared sodium alginate l-cysteine conjugate	963:1046	RESULTS The results of the characterization of prepared sodium alginate l-cysteine conjugate confirmed the thiolation process.
32623912	1	17	dep	OBJECTIVE	224:232	arg1	was					272:274	was	272:274	was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation	272:477	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	1	18	theme	low	407:409	arg1	hydrochloride					432:444	high soluble low permeable ropinirole hydrochloride	394:444	high soluble low permeable ropinirole hydrochloride from the transdermal formulation	394:477	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	2	19	theme	transdermal	586:596	arg1	formulation					598:608	a transdermal formulation	584:608	a transdermal formulation along with IPM as a permeation enhancer	584:648	METHODS Sodium alginate l-cysteine conjugate was prepared and characterized and the same was added into a transdermal formulation along with IPM as a permeation enhancer.
32623912	0	20	from	activity	105:112	arg1	TDDS					141:144	TDDS	141:144	TDDS	141:144	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	11	21	theme	oral	1787:1790	arg1	tablets					1792:1798	marketed oral tablets	1778:1798	marketed oral tablets	1778:1798	Pharmacokinetic studies in rabbits showed that the optimized patch improved bioavailability as compared to marketed oral tablets.
32623912	1	22	theme	ropinirole	421:430	arg1	hydrochloride					432:444	high soluble low permeable ropinirole hydrochloride	394:444	high soluble low permeable ropinirole hydrochloride from the transdermal formulation	394:477	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	12	23	from	formulation	1978:1988	arg1	permeation					1946:1955	ropinirole hydrochloride permeation	1921:1955	ropinirole hydrochloride permeation from the transdermal formulation	1921:1988	CONCLUSIONS The study was concluded that there was a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation.
32623912	1	24	theme	present	255:261	arg1	research					263:270	the present research	251:270	the present research	251:270	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	1	25	theme	sodium	316:321	arg1	conjugate					343:351	sodium alginate l-cysteine conjugate	316:351	sodium alginate l-cysteine conjugate	316:351	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	10	26	theme	target	1476:1481	arg1	flux					1483:1486	The increased target flux	1462:1486	The increased target flux	1462:1486	The increased target flux and maximum drug permeation from an optimized patch suggested that there was an effect of SACC on ropinirole hydrochloride permeation in the presence of IPM as a permeation enhancer.
32623912	1	27	theme	l-cysteine	332:341	arg1	conjugate					343:351	sodium alginate l-cysteine conjugate	316:351	sodium alginate l-cysteine conjugate	316:351	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	10	28	from	patch	1534:1538	arg1	permeation					1505:1514	maximum drug permeation	1492:1514	maximum drug permeation	1492:1514	The increased target flux and maximum drug permeation from an optimized patch suggested that there was an effect of SACC on ropinirole hydrochloride permeation in the presence of IPM as a permeation enhancer.
32623912	10	28	from	patch	1534:1538	arg1	flux					1483:1486	The increased target flux	1462:1486	The increased target flux	1462:1486	The increased target flux and maximum drug permeation from an optimized patch suggested that there was an effect of SACC on ropinirole hydrochloride permeation in the presence of IPM as a permeation enhancer.
32623912	4	29	theme	optimized	794:802	arg1	formulation					804:814	optimized formulation	794:814	optimized formulation	794:814	The results were fed into Design Expert® Software to obtain optimized formulation.
32623912	0	30	theme	permeation	84:93	arg1	activity					105:112	the permeation enhancing activity	80:112	the permeation enhancing activity of BCS class III drug from TDDS	80:144	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	6	31	theme	conjugate	1038:1046	arg1	characterization					982:997	the characterization	978:997	the characterization of prepared sodium alginate l-cysteine conjugate	978:1046	RESULTS The results of the characterization of prepared sodium alginate l-cysteine conjugate confirmed the thiolation process.
32623912	10	32	theme	drug	1500:1503	arg1	permeation					1505:1514	maximum drug permeation	1492:1514	maximum drug permeation	1492:1514	The increased target flux and maximum drug permeation from an optimized patch suggested that there was an effect of SACC on ropinirole hydrochloride permeation in the presence of IPM as a permeation enhancer.
32623912	1	33	theme	enhancer	368:375	arg1	optimization					300:311	optimization	300:311	optimization	300:311	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	1	33	theme	enhancer	368:375	arg1	effect					289:294	effect	289:294	effect	289:294	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	12	34	theme	ropinirole	1921:1930	arg1	permeation					1946:1955	ropinirole hydrochloride permeation	1921:1955	ropinirole hydrochloride permeation from the transdermal formulation	1921:1988	CONCLUSIONS The study was concluded that there was a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation.
32623912	11	35	from	studies	1687:1693	arg1	rabbits					1698:1704	rabbits	1698:1704	rabbits	1698:1704	Pharmacokinetic studies in rabbits showed that the optimized patch improved bioavailability as compared to marketed oral tablets.
32623912	4	36	theme	Expert®	767:773	arg1	Software					775:782	Design Expert® Software	760:782	Design Expert® Software	760:782	The results were fed into Design Expert® Software to obtain optimized formulation.
32623912	9	37	from	%	1361:1361	arg1	formulation					1297:1307	the optimized formulation	1283:1307	the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight	1283:1383	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	0	38	dep	enhance	72:78	arg1	optimization					147:158	optimization	147:158	optimization by central composite design and in vivo pharmacokinetics study	147:221	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	10	39	theme	optimized	1524:1532	arg1	patch					1534:1538	an optimized patch	1521:1538	an optimized patch	1521:1538	The increased target flux and maximum drug permeation from an optimized patch suggested that there was an effect of SACC on ropinirole hydrochloride permeation in the presence of IPM as a permeation enhancer.
32623912	0	40	theme	sodium	8:13	arg1	conjugate					35:43	sodium l-cysteine alginate conjugate	8:43	sodium l-cysteine alginate conjugate	8:43	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	12	41	theme	conjugate	1900:1908	arg1	effect					1863:1868	a positive effect	1852:1868	a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation	1852:1988	CONCLUSIONS The study was concluded that there was a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation.
32623912	7	42	with	compatible	1128:1137	arg1	excipients					1152:1161	all the excipients	1144:1161	all the excipients	1144:1161	Stability studies suggested that the drug was compatible with all the excipients.
32623912	2	43	theme	alginate	495:502	arg1	conjugate					515:523	METHODS Sodium alginate l-cysteine conjugate	480:523	METHODS Sodium alginate l-cysteine conjugate	480:523	METHODS Sodium alginate l-cysteine conjugate was prepared and characterized and the same was added into a transdermal formulation along with IPM as a permeation enhancer.
32623912	5	44	theme	optimized	821:829	arg1	formulation					831:841	The optimized formulation	817:841	The optimized formulation	817:841	The optimized formulation was evaluated for physicochemical, ex vivo permeation, stability, skin irritation, and pharmacokinetic studies.
32623912	9	45	theme	polymers	1369:1376	arg1	weight					1378:1383	polymers weight	1369:1383	polymers weight	1369:1383	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	0	46	theme	alginate	26:33	arg1	conjugate					35:43	sodium l-cysteine alginate conjugate	8:43	sodium l-cysteine alginate conjugate	8:43	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	2	47	theme	METHODS	480:486	arg1	conjugate					515:523	METHODS Sodium alginate l-cysteine conjugate	480:523	METHODS Sodium alginate l-cysteine conjugate	480:523	METHODS Sodium alginate l-cysteine conjugate was prepared and characterized and the same was added into a transdermal formulation along with IPM as a permeation enhancer.
32623912	0	48	theme	myristate	59:67	arg1	Role					0:3	Role	0:3	Role of sodium l-cysteine alginate conjugate and isopropyl myristate	0:67	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	12	49	theme	IPM	1914:1916	arg1	effect					1863:1868	a positive effect	1852:1868	a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation	1852:1988	CONCLUSIONS The study was concluded that there was a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation.
32623912	9	50	theme	steady	1399:1404	arg1	9.004 µg/cm2/h					1417:1430	target steady state flux 9.004 µg/cm2/h	1392:1430	target steady state flux 9.004 µg/cm2/h with maximum drug permeation	1392:1459	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	12	51	theme	alginate	1880:1887	arg1	conjugate					1900:1908	sodium alginate l-cysteine conjugate	1873:1908	sodium alginate l-cysteine conjugate	1873:1908	CONCLUSIONS The study was concluded that there was a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation.
32623912	3	52	theme	solvent	696:702	arg1	method					712:717	solvent casting method	696:717	solvent casting method	696:717	Twelve primary formulations were prepared by solvent casting method and evaluated.
32623912	5	53	dep	ex	878:879	arg1	vivo					881:884	vivo	881:884	vivo	881:884	The optimized formulation was evaluated for physicochemical, ex vivo permeation, stability, skin irritation, and pharmacokinetic studies.
32623912	9	54	with	9.004 µg/cm2/h	1417:1430	arg1	permeation					1450:1459	maximum drug permeation	1437:1459	maximum drug permeation	1437:1459	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	9	55	theme	flux	1412:1415	arg1	9.004 µg/cm2/h					1417:1430	target steady state flux 9.004 µg/cm2/h	1392:1430	target steady state flux 9.004 µg/cm2/h with maximum drug permeation	1392:1459	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	8	56	theme	patch	1194:1198	arg1	images					1168:1173	SEM images	1164:1173	SEM images of the transdermal patch	1164:1198	SEM images of the transdermal patch revealed that the amorphous drug was uniformly distributed.
32623912	1	57	from	formulation	467:477	arg1	permeation					380:389	permeation	380:389	permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation	380:477	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	1	57	from	formulation	467:477	arg1	hydrochloride					432:444	high soluble low permeable ropinirole hydrochloride	394:444	high soluble low permeable ropinirole hydrochloride from the transdermal formulation	394:477	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	11	58	theme	Pharmacokinetic	1671:1685	arg1	studies					1687:1693	Pharmacokinetic studies	1671:1693	Pharmacokinetic studies in rabbits	1671:1704	Pharmacokinetic studies in rabbits showed that the optimized patch improved bioavailability as compared to marketed oral tablets.
32623912	0	59	theme	central	163:169	arg1	design					181:186	central composite design	163:186	central composite design	163:186	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	10	60	theme	hydrochloride	1597:1609	arg1	permeation					1611:1620	ropinirole hydrochloride permeation	1586:1620	ropinirole hydrochloride permeation	1586:1620	The increased target flux and maximum drug permeation from an optimized patch suggested that there was an effect of SACC on ropinirole hydrochloride permeation in the presence of IPM as a permeation enhancer.
32623912	1	61	from	effect	289:294	arg1	permeation					380:389	permeation	380:389	permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation	380:477	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	9	62	theme	drug	1445:1448	arg1	permeation					1450:1459	maximum drug permeation	1437:1459	maximum drug permeation	1437:1459	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	8	63	theme	amorphous	1218:1226	arg1	drug					1228:1231	the amorphous drug	1214:1231	the amorphous drug	1214:1231	SEM images of the transdermal patch revealed that the amorphous drug was uniformly distributed.
32623912	0	64	theme	in vivo	192:198	arg1	pharmacokinetics					200:215	in vivo pharmacokinetics	192:215	in vivo pharmacokinetics	192:215	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	5	65	theme	skin	909:912	arg1	irritation					914:923	skin irritation	909:923	skin irritation	909:923	The optimized formulation was evaluated for physicochemical, ex vivo permeation, stability, skin irritation, and pharmacokinetic studies.
32623912	6	66	theme	l-cysteine	1027:1036	arg1	conjugate					1038:1046	prepared sodium alginate l-cysteine conjugate	1002:1046	prepared sodium alginate l-cysteine conjugate	1002:1046	RESULTS The results of the characterization of prepared sodium alginate l-cysteine conjugate confirmed the thiolation process.
32623912	2	67	theme	permeation	630:639	arg1	enhancer					641:648	a permeation enhancer	628:648	a permeation enhancer	628:648	METHODS Sodium alginate l-cysteine conjugate was prepared and characterized and the same was added into a transdermal formulation along with IPM as a permeation enhancer.
32623912	0	68	theme	class	121:125	arg1	drug					131:134	BCS class III drug	117:134	BCS class III drug from TDDS	117:144	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	0	69	dep	design	181:186	arg1	study					217:221	study	217:221	study	217:221	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	6	70	theme	sodium	1011:1016	arg1	conjugate					1038:1046	prepared sodium alginate l-cysteine conjugate	1002:1046	prepared sodium alginate l-cysteine conjugate	1002:1046	RESULTS The results of the characterization of prepared sodium alginate l-cysteine conjugate confirmed the thiolation process.
32623912	0	71	theme	drug	131:134	arg1	activity					105:112	the permeation enhancing activity	80:112	the permeation enhancing activity of BCS class III drug from TDDS	80:144	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	10	72	theme	IPM	1641:1643	arg1	presence					1629:1636	the presence	1625:1636	the presence of IPM as a permeation enhancer	1625:1668	The increased target flux and maximum drug permeation from an optimized patch suggested that there was an effect of SACC on ropinirole hydrochloride permeation in the presence of IPM as a permeation enhancer.
32623912	1	73	theme	soluble	399:405	arg1	hydrochloride					432:444	high soluble low permeable ropinirole hydrochloride	394:444	high soluble low permeable ropinirole hydrochloride from the transdermal formulation	394:477	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	12	74	theme	l-cysteine	1889:1898	arg1	conjugate					1900:1908	sodium alginate l-cysteine conjugate	1873:1908	sodium alginate l-cysteine conjugate	1873:1908	CONCLUSIONS The study was concluded that there was a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation.
32623912	1	75	theme	permeable	411:419	arg1	hydrochloride					432:444	high soluble low permeable ropinirole hydrochloride	394:444	high soluble low permeable ropinirole hydrochloride from the transdermal formulation	394:477	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	1	76	theme	hydrochloride	432:444	arg1	permeation					380:389	permeation	380:389	permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation	380:477	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	5	77	theme	ex	878:879	arg1	permeation					886:895	ex vivo permeation	878:895	ex vivo permeation	878:895	The optimized formulation was evaluated for physicochemical, ex vivo permeation, stability, skin irritation, and pharmacokinetic studies.
32623912	11	78	theme	marketed	1778:1785	arg1	tablets					1792:1798	marketed oral tablets	1778:1798	marketed oral tablets	1778:1798	Pharmacokinetic studies in rabbits showed that the optimized patch improved bioavailability as compared to marketed oral tablets.
32623912	1	79	theme	alginate	323:330	arg1	conjugate					343:351	sodium alginate l-cysteine conjugate	316:351	sodium alginate l-cysteine conjugate	316:351	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	12	80	theme	transdermal	1966:1976	arg1	formulation					1978:1988	the transdermal formulation	1962:1988	the transdermal formulation	1962:1988	CONCLUSIONS The study was concluded that there was a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation.
32623912	5	81	theme	pharmacokinetic	930:944	arg1	studies					946:952	pharmacokinetic studies	930:952	pharmacokinetic studies	930:952	The optimized formulation was evaluated for physicochemical, ex vivo permeation, stability, skin irritation, and pharmacokinetic studies.
32623912	6	82	theme	thiolation	1062:1071	arg1	process					1073:1079	the thiolation process	1058:1079	the thiolation process	1058:1079	RESULTS The results of the characterization of prepared sodium alginate l-cysteine conjugate confirmed the thiolation process.
32623912	2	83	theme	l-cysteine	504:513	arg1	conjugate					515:523	METHODS Sodium alginate l-cysteine conjugate	480:523	METHODS Sodium alginate l-cysteine conjugate	480:523	METHODS Sodium alginate l-cysteine conjugate was prepared and characterized and the same was added into a transdermal formulation along with IPM as a permeation enhancer.
32623912	10	84	theme	increased	1466:1474	arg1	flux					1483:1486	The increased target flux	1462:1486	The increased target flux	1462:1486	The increased target flux and maximum drug permeation from an optimized patch suggested that there was an effect of SACC on ropinirole hydrochloride permeation in the presence of IPM as a permeation enhancer.
32623912	12	85	dep	CONCLUSIONS	1801:1811	arg1	concluded					1827:1835	concluded	1827:1835	was concluded that there was a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation	1823:1988	CONCLUSIONS The study was concluded that there was a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation.
32623912	0	86	theme	enhancing	95:103	arg1	activity					105:112	the permeation enhancing activity	80:112	the permeation enhancing activity of BCS class III drug from TDDS	80:144	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	1	87	theme	conjugate	343:351	arg1	optimization					300:311	optimization	300:311	optimization	300:311	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	1	87	theme	conjugate	343:351	arg1	effect					289:294	effect	289:294	effect	289:294	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	1	88	from	permeation	380:389	arg1	formulation					467:477	the transdermal formulation	451:477	the transdermal formulation	451:477	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	1	89	theme	permeation	357:366	arg1	enhancer					368:375	permeation enhancer	357:375	permeation enhancer	357:375	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	12	90	theme	hydrochloride	1932:1944	arg1	permeation					1946:1955	ropinirole hydrochloride permeation	1921:1955	ropinirole hydrochloride permeation from the transdermal formulation	1921:1988	CONCLUSIONS The study was concluded that there was a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation.
32623912	1	91	dep	effect	289:294	arg1	the					285:287	the	285:287	the	285:287	OBJECTIVE The objective of the present research was to study the effect and optimization of sodium alginate l-cysteine conjugate and permeation enhancer on permeation of high soluble low permeable ropinirole hydrochloride from the transdermal formulation.
32623912	10	92	theme	maximum	1492:1498	arg1	permeation					1505:1514	maximum drug permeation	1492:1514	maximum drug permeation	1492:1514	The increased target flux and maximum drug permeation from an optimized patch suggested that there was an effect of SACC on ropinirole hydrochloride permeation in the presence of IPM as a permeation enhancer.
32623912	9	93	theme	IPM	1354:1356	arg1	weight					1378:1383	polymers weight	1369:1383	polymers weight	1369:1383	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	9	93	theme	IPM	1354:1356	arg1	%					1361:1361	IPM 9.5%w/w	1354:1364	IPM 9.5%w/w of polymers weight	1354:1383	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	4	94	theme	Design	760:765	arg1	Software					775:782	Design Expert® Software	760:782	Design Expert® Software	760:782	The results were fed into Design Expert® Software to obtain optimized formulation.
32623912	10	95	theme	permeation	1650:1659	arg1	enhancer					1661:1668	a permeation enhancer	1648:1668	a permeation enhancer	1648:1668	The increased target flux and maximum drug permeation from an optimized patch suggested that there was an effect of SACC on ropinirole hydrochloride permeation in the presence of IPM as a permeation enhancer.
32623912	0	96	theme	l-cysteine	15:24	arg1	conjugate					35:43	sodium l-cysteine alginate conjugate	8:43	sodium l-cysteine alginate conjugate	8:43	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	9	97	dep	SA	1335:1336	arg1	SACC					1339:1342	SACC	1339:1342	SA: SACC; 4:6	1335:1347	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	9	97	dep	SA	1335:1336	arg1	4:6					1345:1347	4:6	1345:1347	SA: SACC; 4:6	1335:1347	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	11	98	theme	optimized	1722:1730	arg1	patch					1732:1736	the optimized patch	1718:1736	the optimized patch	1718:1736	Pharmacokinetic studies in rabbits showed that the optimized patch improved bioavailability as compared to marketed oral tablets.
32623912	0	99	theme	conjugate	35:43	arg1	Role					0:3	Role	0:3	Role of sodium l-cysteine alginate conjugate and isopropyl myristate	0:67	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	8	100	theme	SEM	1164:1166	arg1	images					1168:1173	SEM images	1164:1173	SEM images of the transdermal patch	1164:1198	SEM images of the transdermal patch revealed that the amorphous drug was uniformly distributed.
32623912	2	101	theme	Sodium	488:493	arg1	conjugate					515:523	METHODS Sodium alginate l-cysteine conjugate	480:523	METHODS Sodium alginate l-cysteine conjugate	480:523	METHODS Sodium alginate l-cysteine conjugate was prepared and characterized and the same was added into a transdermal formulation along with IPM as a permeation enhancer.
32623912	3	102	theme	primary	658:664	arg1	formulations					666:677	Twelve primary formulations	651:677	Twelve primary formulations	651:677	Twelve primary formulations were prepared by solvent casting method and evaluated.
32623912	0	103	theme	isopropyl	49:57	arg1	myristate					59:67	isopropyl myristate	49:67	isopropyl myristate	49:67	Role of sodium l-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and in vivo pharmacokinetics study.
32623912	9	104	theme	weight	1378:1383	arg1	weight					1378:1383	polymers weight	1369:1383	polymers weight	1369:1383	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	9	104	theme	weight	1378:1383	arg1	SA					1335:1336	SA	1335:1336	SA: SACC; 4:6	1335:1347	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	9	104	theme	weight	1378:1383	arg1	ratio					1328:1332	the polymer's ratio	1314:1332	the polymer's ratio (SA: SACC; 4:6)	1314:1348	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	9	104	theme	weight	1378:1383	arg1	%					1361:1361	IPM 9.5%w/w	1354:1364	IPM 9.5%w/w of polymers weight	1354:1383	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	12	105	theme	sodium	1873:1878	arg1	conjugate					1900:1908	sodium alginate l-cysteine conjugate	1873:1908	sodium alginate l-cysteine conjugate	1873:1908	CONCLUSIONS The study was concluded that there was a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation.
32623912	10	106	from	effect	1568:1573	arg1	permeation					1611:1620	ropinirole hydrochloride permeation	1586:1620	ropinirole hydrochloride permeation	1586:1620	The increased target flux and maximum drug permeation from an optimized patch suggested that there was an effect of SACC on ropinirole hydrochloride permeation in the presence of IPM as a permeation enhancer.
32623912	12	107	from	effect	1863:1868	arg1	permeation					1946:1955	ropinirole hydrochloride permeation	1921:1955	ropinirole hydrochloride permeation from the transdermal formulation	1921:1988	CONCLUSIONS The study was concluded that there was a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation.
32623912	3	108	theme	casting	704:710	arg1	method					712:717	solvent casting method	696:717	solvent casting method	696:717	Twelve primary formulations were prepared by solvent casting method and evaluated.
32623912	9	109	theme	target	1392:1397	arg1	9.004 µg/cm2/h					1417:1430	target steady state flux 9.004 µg/cm2/h	1392:1430	target steady state flux 9.004 µg/cm2/h with maximum drug permeation	1392:1459	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	8	110	theme	transdermal	1182:1192	arg1	patch					1194:1198	the transdermal patch	1178:1198	the transdermal patch	1178:1198	SEM images of the transdermal patch revealed that the amorphous drug was uniformly distributed.
32623912	12	111	theme	positive	1854:1861	arg1	effect					1863:1868	a positive effect	1852:1868	a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation	1852:1988	CONCLUSIONS The study was concluded that there was a positive effect of sodium alginate l-cysteine conjugate and IPM on ropinirole hydrochloride permeation from the transdermal formulation.
32623912	9	112	theme	state	1406:1410	arg1	9.004 µg/cm2/h					1417:1430	target steady state flux 9.004 µg/cm2/h	1392:1430	target steady state flux 9.004 µg/cm2/h with maximum drug permeation	1392:1459	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
32623912	9	113	from	ratio	1328:1332	arg1	formulation					1297:1307	the optimized formulation	1283:1307	the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight	1283:1383	From the design space, the optimized formulation from the polymer's ratio (SA: SACC; 4:6) and IPM 9.5%w/w of polymers weight showed target steady state flux 9.004 µg/cm2/h with maximum drug permeation.
33815445	9	0	theme	helminth	1864:1871	arg1	N-glycans					1873:1881	tailor-made helminth N-glycans	1852:1881	tailor-made helminth N-glycans	1852:1881	Effective knockout of these enzymes could allow the production of therapeutically relevant glycoproteins with tailor-made helminth N-glycans in plants.
33815445	3	1	theme	helminth	560:567	arg1	glycoproteins					569:581	helminth glycoproteins	560:581	helminth glycoproteins	560:581	Recently, pioneering work has shown that helminth glycoproteins can be produced transiently in Nicotiana benthamiana plants while simultaneously mimicking their native helminth N-glycan composition by co-expression of desired glycosyltransferases.
33815445	4	2	theme	N-glycans	996:1004	arg1	synthesis					983:991	the synthesis	979:991	the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN)	979:1054	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	9	3	gly	glycoproteins	1833:1845	arg1	glycoproteins					1833:1845	therapeutically relevant glycoproteins	1808:1845	therapeutically relevant glycoproteins with tailor-made helminth N-glycans	1808:1881	Effective knockout of these enzymes could allow the production of therapeutically relevant glycoproteins with tailor-made helminth N-glycans in plants.
33815445	6	4	theme	GalNAc	1289:1294	arg1	N-glycans					1308:1316	N-glycans	1308:1316	N-glycans	1308:1316	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	6	4	theme	GalNAc	1289:1294	arg1	residues					1296:1303	antennary GalNAc residues	1279:1303	antennary GalNAc residues of N-glycans	1279:1316	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	6	5	gly	glycoprotein	1340:1351	arg1	glycoprotein					1340:1351	the model helminth glycoprotein kappa-5	1321:1359	the model helminth glycoprotein kappa-5	1321:1359	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	4	6	theme	efficient	776:784	arg1	"					802:802	efficient "helminthization"	776:802	efficient "helminthization" of N-glycans in plants by glyco-engineering	776:846	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	9	7	theme	relevant	1824:1831	arg1	glycoproteins					1833:1845	therapeutically relevant glycoproteins	1808:1845	therapeutically relevant glycoproteins with tailor-made helminth N-glycans	1808:1881	Effective knockout of these enzymes could allow the production of therapeutically relevant glycoproteins with tailor-made helminth N-glycans in plants.
33815445	0	8	theme	Recombinant	139:149	arg1	Glycoproteins					151:163	Recombinant Glycoproteins	139:163	Recombinant Glycoproteins	139:163	β-Hexosaminidases Along the Secretory Pathway of Nicotiana benthamiana Have Distinct Specificities Toward Engineered Helminth N-Glycans on Recombinant Glycoproteins.
33815445	3	9	theme	benthamiana	624:634	arg1	plants					636:641	Nicotiana benthamiana plants	614:641	Nicotiana benthamiana plants	614:641	Recently, pioneering work has shown that helminth glycoproteins can be produced transiently in Nicotiana benthamiana plants while simultaneously mimicking their native helminth N-glycan composition by co-expression of desired glycosyltransferases.
33815445	9	10	from	production	1794:1803	arg1	plants					1886:1891	plants	1886:1891	plants	1886:1891	Effective knockout of these enzymes could allow the production of therapeutically relevant glycoproteins with tailor-made helminth N-glycans in plants.
33815445	7	11	theme	strict	1489:1494	arg1	activity					1516:1523	strict β-galactosaminidase activity	1489:1523	strict β-galactosaminidase activity	1489:1523	Furthermore, we reveal that each member of the HEXO family has a distinct specificity for N-glycan substrates, where HEXO2 has strict β-galactosaminidase activity, whereas HEXO3 cleaves both GlcNAc and GalNAc.
33815445	7	12	theme	distinct	1427:1434	arg1	specificity					1436:1446	a distinct specificity	1425:1446	a distinct specificity	1425:1446	Furthermore, we reveal that each member of the HEXO family has a distinct specificity for N-glycan substrates, where HEXO2 has strict β-galactosaminidase activity, whereas HEXO3 cleaves both GlcNAc and GalNAc.
33815445	7	13	contain	has	1421:1423	arg2	specificity					1436:1446	a distinct specificity	1425:1446	a distinct specificity	1425:1446	Furthermore, we reveal that each member of the HEXO family has a distinct specificity for N-glycan substrates, where HEXO2 has strict β-galactosaminidase activity, whereas HEXO3 cleaves both GlcNAc and GalNAc.
33815445	7	13	contain	has	1421:1423	arg1	member					1395:1400	each member	1390:1400	each member of the HEXO family	1390:1419	Furthermore, we reveal that each member of the HEXO family has a distinct specificity for N-glycan substrates, where HEXO2 has strict β-galactosaminidase activity, whereas HEXO3 cleaves both GlcNAc and GalNAc.
33815445	3	14	theme	native	680:685	arg1	composition					705:715	their native helminth N-glycan composition	674:715	their native helminth N-glycan composition	674:715	Recently, pioneering work has shown that helminth glycoproteins can be produced transiently in Nicotiana benthamiana plants while simultaneously mimicking their native helminth N-glycan composition by co-expression of desired glycosyltransferases.
33815445	1	15	theme	immunomodulatory	237:252	arg1	glycoproteins					254:266	immunomodulatory glycoproteins	237:266	immunomodulatory glycoproteins with the potential to treat inflammatory disorders	237:317	Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
33815445	4	16	theme	antennary	1011:1019	arg1	GalNAcβ1-4GlcNAc					1021:1036	antennary GalNAcβ1-4GlcNAc	1011:1036	antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN)	1011:1054	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	6	17	theme	glycoprotein	1340:1351	arg1	kappa-5					1353:1359	the model helminth glycoprotein kappa-5	1321:1359	the model helminth glycoprotein kappa-5	1321:1359	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	4	18	with	N-glycans	996:1004	arg1	GalNAcβ1-4GlcNAc					1021:1036	antennary GalNAcβ1-4GlcNAc	1011:1036	antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN)	1011:1054	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	6	19	theme	model	1325:1329	arg1	kappa-5					1353:1359	the model helminth glycoprotein kappa-5	1321:1359	the model helminth glycoprotein kappa-5	1321:1359	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	5	20	theme	biochemical	1167:1177	arg1	activity					1179:1186	the biochemical activity	1163:1186	the biochemical activity of these enzymes	1163:1203	In this study, we cloned novel β-hexosaminidase open reading frames from N. benthamiana and characterized the biochemical activity of these enzymes.
33815445	7	21	theme	N-glycan	1452:1459	arg1	substrates					1461:1470	N-glycan substrates	1452:1470	N-glycan substrates	1452:1470	Furthermore, we reveal that each member of the HEXO family has a distinct specificity for N-glycan substrates, where HEXO2 has strict β-galactosaminidase activity, whereas HEXO3 cleaves both GlcNAc and GalNAc.
33815445	4	22	theme	helminthization	787:801	arg1	"					802:802	efficient "helminthization"	776:802	efficient "helminthization" of N-glycans in plants by glyco-engineering	776:846	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	4	23	dep	GalNAcβ1-4GlcNAc	1021:1036	arg1	LDN					1051:1053	LDN	1051:1053	LDN	1051:1053	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	4	23	dep	GalNAcβ1-4GlcNAc	1021:1036	arg1	LacdiNAc					1039:1046	LacdiNAc	1039:1046	LacdiNAc	1039:1046	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	3	24	theme	N-glycan	696:703	arg1	composition					705:715	their native helminth N-glycan composition	674:715	their native helminth N-glycan composition	674:715	Recently, pioneering work has shown that helminth glycoproteins can be produced transiently in Nicotiana benthamiana plants while simultaneously mimicking their native helminth N-glycan composition by co-expression of desired glycosyltransferases.
33815445	1	25	theme	parasitic	180:188	arg1	helminths					197:205	helminths	197:205	helminths	197:205	Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
33815445	1	25	theme	parasitic	180:188	arg1	worms					190:194	parasitic worms	180:194	parasitic worms (helminths)	180:206	Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
33815445	0	26	theme	Engineered	106:115	arg1	N-Glycans					126:134	Engineered Helminth N-Glycans	106:134	Engineered Helminth N-Glycans	106:134	β-Hexosaminidases Along the Secretory Pathway of Nicotiana benthamiana Have Distinct Specificities Toward Engineered Helminth N-Glycans on Recombinant Glycoproteins.
33815445	8	27	theme	LDN	1631:1633	arg1	cleavage					1635:1642	LDN cleavage	1631:1642	LDN cleavage	1631:1642	The identification of HEXO2 and HEXO3 as major targets for LDN cleavage will enable a targeted genome editing approach to reduce undesired processing of these N-glycans.
33815445	4	28	theme	undesired	876:884	arg1	truncation					886:895	the undesired truncation	872:895	the undesired truncation of complex N-glycans	872:916	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	5	29	theme	novel	1082:1086	arg1	frames					1118:1123	novel β-hexosaminidase open reading frames	1082:1123	novel β-hexosaminidase open reading frames	1082:1123	In this study, we cloned novel β-hexosaminidase open reading frames from N. benthamiana and characterized the biochemical activity of these enzymes.
33815445	2	30	theme	parasite-derived	492:507	arg1	proteins					509:516	native parasite-derived proteins	485:516	native parasite-derived proteins	485:516	Yet, the identification of single molecules that can be developed into novel biopharmaceuticals is hampered by the limited availability of native parasite-derived proteins.
33815445	2	31	theme	novel	417:421	arg1	biopharmaceuticals					423:440	novel biopharmaceuticals	417:440	novel biopharmaceuticals	417:440	Yet, the identification of single molecules that can be developed into novel biopharmaceuticals is hampered by the limited availability of native parasite-derived proteins.
33815445	1	32	contain	contain	208:214	arg2	collection					223:232	a wide collection	216:232	a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders	216:317	Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
33815445	1	32	contain	contain	208:214	arg1	Secretions					166:175	Secretions	166:175	Secretions of parasitic worms (helminths)	166:206	Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
33815445	2	33	theme	limited	461:467	arg1	availability					469:480	the limited availability	457:480	the limited availability of native parasite-derived proteins	457:516	Yet, the identification of single molecules that can be developed into novel biopharmaceuticals is hampered by the limited availability of native parasite-derived proteins.
33815445	1	34	theme	autoimmune	325:334	arg1	diseases					336:343	autoimmune diseases	325:343	autoimmune diseases	325:343	Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
33815445	8	35	theme	genome	1667:1672	arg1	approach					1682:1689	a targeted genome editing approach	1656:1689	a targeted genome editing approach to reduce undesired processing of these N-glycans	1656:1739	The identification of HEXO2 and HEXO3 as major targets for LDN cleavage will enable a targeted genome editing approach to reduce undesired processing of these N-glycans.
33815445	3	36	theme	glycosyltransferases	745:764	arg1	co-expression					720:732	co-expression	720:732	co-expression of desired glycosyltransferases	720:764	Recently, pioneering work has shown that helminth glycoproteins can be produced transiently in Nicotiana benthamiana plants while simultaneously mimicking their native helminth N-glycan composition by co-expression of desired glycosyltransferases.
33815445	6	37	from	cleavage	1267:1274	arg1	kappa-5					1353:1359	the model helminth glycoprotein kappa-5	1321:1359	the model helminth glycoprotein kappa-5	1321:1359	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	5	38	theme	N.	1130:1131	arg1	benthamiana					1133:1143	N. benthamiana	1130:1143	N. benthamiana	1130:1143	In this study, we cloned novel β-hexosaminidase open reading frames from N. benthamiana and characterized the biochemical activity of these enzymes.
33815445	7	39	theme	HEXO	1409:1412	arg1	family					1414:1419	the HEXO family	1405:1419	the HEXO family	1405:1419	Furthermore, we reveal that each member of the HEXO family has a distinct specificity for N-glycan substrates, where HEXO2 has strict β-galactosaminidase activity, whereas HEXO3 cleaves both GlcNAc and GalNAc.
33815445	2	40	theme	molecules	380:388	arg1	identification					355:368	the identification	351:368	the identification of single molecules that can be developed into novel biopharmaceuticals	351:440	Yet, the identification of single molecules that can be developed into novel biopharmaceuticals is hampered by the limited availability of native parasite-derived proteins.
33815445	0	41	theme	Nicotiana	49:57	arg1	benthamiana					59:69	Nicotiana benthamiana	49:69	Nicotiana benthamiana	49:69	β-Hexosaminidases Along the Secretory Pathway of Nicotiana benthamiana Have Distinct Specificities Toward Engineered Helminth N-Glycans on Recombinant Glycoproteins.
33815445	3	42	theme	pioneering	529:538	arg1	work					540:543	pioneering work	529:543	pioneering work	529:543	Recently, pioneering work has shown that helminth glycoproteins can be produced transiently in Nicotiana benthamiana plants while simultaneously mimicking their native helminth N-glycan composition by co-expression of desired glycosyltransferases.
33815445	4	43	from	plants	820:825	arg1	"					802:802	efficient "helminthization"	776:802	efficient "helminthization" of N-glycans in plants by glyco-engineering	776:846	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	1	44	theme	glycoproteins	254:266	arg1	collection					223:232	a wide collection	216:232	a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders	216:317	Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
33815445	5	45	theme	open	1105:1108	arg1	frames					1118:1123	novel β-hexosaminidase open reading frames	1082:1123	novel β-hexosaminidase open reading frames	1082:1123	In this study, we cloned novel β-hexosaminidase open reading frames from N. benthamiana and characterized the biochemical activity of these enzymes.
33815445	4	46	theme	N-glycans	908:916	arg1	truncation					886:895	the undesired truncation	872:895	the undesired truncation of complex N-glycans	872:916	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	4	47	from	N-glycans	807:815	arg1	plants					820:825	plants	820:825	plants	820:825	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	1	48	with	glycoproteins	254:266	arg1	potential					277:285	the potential to treat inflammatory disorders	273:317	the potential to treat inflammatory disorders	273:317	Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
33815445	4	49	from	"	802:802	arg1	plants					820:825	plants	820:825	plants	820:825	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	7	50	contain	has	1485:1487	arg2	activity					1516:1523	strict β-galactosaminidase activity	1489:1523	strict β-galactosaminidase activity	1489:1523	Furthermore, we reveal that each member of the HEXO family has a distinct specificity for N-glycan substrates, where HEXO2 has strict β-galactosaminidase activity, whereas HEXO3 cleaves both GlcNAc and GalNAc.
33815445	7	50	contain	has	1485:1487	arg1	HEXO2					1479:1483	HEXO2	1479:1483	HEXO2	1479:1483	Furthermore, we reveal that each member of the HEXO family has a distinct specificity for N-glycan substrates, where HEXO2 has strict β-galactosaminidase activity, whereas HEXO3 cleaves both GlcNAc and GalNAc.
33815445	9	51	theme	enzymes	1770:1776	arg1	knockout					1752:1759	knockout	1752:1759	knockout	1752:1759	Effective knockout of these enzymes could allow the production of therapeutically relevant glycoproteins with tailor-made helminth N-glycans in plants.
33815445	1	52	theme	inflammatory	296:307	arg1	disorders					309:317	inflammatory disorders	296:317	inflammatory disorders	296:317	Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
33815445	6	53	theme	residues	1296:1303	arg1	cleavage					1267:1274	the cleavage	1263:1274	the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5	1263:1359	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	6	54	theme	antennary	1279:1287	arg1	N-glycans					1308:1316	N-glycans	1308:1316	N-glycans	1308:1316	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	6	54	theme	antennary	1279:1287	arg1	residues					1296:1303	antennary GalNAc residues	1279:1303	antennary GalNAc residues of N-glycans	1279:1316	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	3	55	theme	Nicotiana	614:622	arg1	plants					636:641	Nicotiana benthamiana plants	614:641	Nicotiana benthamiana plants	614:641	Recently, pioneering work has shown that helminth glycoproteins can be produced transiently in Nicotiana benthamiana plants while simultaneously mimicking their native helminth N-glycan composition by co-expression of desired glycosyltransferases.
33815445	1	56	theme	wide	218:221	arg1	collection					223:232	a wide collection	216:232	a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders	216:317	Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
33815445	9	57	theme	glycoproteins	1833:1845	arg1	production					1794:1803	the production	1790:1803	the production of therapeutically relevant glycoproteins with tailor-made helminth N-glycans in plants	1790:1891	Effective knockout of these enzymes could allow the production of therapeutically relevant glycoproteins with tailor-made helminth N-glycans in plants.
33815445	2	58	theme	single	373:378	arg1	molecules					380:388	single molecules	373:388	single molecules that can be developed into novel biopharmaceuticals	373:440	Yet, the identification of single molecules that can be developed into novel biopharmaceuticals is hampered by the limited availability of native parasite-derived proteins.
33815445	9	59	theme	tailor-made	1852:1862	arg1	N-glycans					1873:1881	tailor-made helminth N-glycans	1852:1881	tailor-made helminth N-glycans	1852:1881	Effective knockout of these enzymes could allow the production of therapeutically relevant glycoproteins with tailor-made helminth N-glycans in plants.
33815445	7	60	theme	β-galactosaminidase	1496:1514	arg1	activity					1516:1523	strict β-galactosaminidase activity	1489:1523	strict β-galactosaminidase activity	1489:1523	Furthermore, we reveal that each member of the HEXO family has a distinct specificity for N-glycan substrates, where HEXO2 has strict β-galactosaminidase activity, whereas HEXO3 cleaves both GlcNAc and GalNAc.
33815445	8	61	theme	HEXO2	1594:1598	arg1	identification					1576:1589	The identification	1572:1589	The identification of HEXO2 and HEXO3 as major targets for LDN cleavage	1572:1642	The identification of HEXO2 and HEXO3 as major targets for LDN cleavage will enable a targeted genome editing approach to reduce undesired processing of these N-glycans.
33815445	6	62	theme	helminth	1331:1338	arg1	kappa-5					1353:1359	the model helminth glycoprotein kappa-5	1321:1359	the model helminth glycoprotein kappa-5	1321:1359	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	4	63	theme	N-glycans	807:815	arg1	"					802:802	efficient "helminthization"	776:802	efficient "helminthization" of N-glycans in plants by glyco-engineering	776:846	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	8	64	theme	HEXO3	1604:1608	arg1	identification					1576:1589	The identification	1572:1589	The identification of HEXO2 and HEXO3 as major targets for LDN cleavage	1572:1642	The identification of HEXO2 and HEXO3 as major targets for LDN cleavage will enable a targeted genome editing approach to reduce undesired processing of these N-glycans.
33815445	0	65	theme	Distinct	76:83	arg1	Specificities					85:97	Distinct Specificities	76:97	Distinct Specificities Toward Engineered Helminth N-Glycans	76:134	β-Hexosaminidases Along the Secretory Pathway of Nicotiana benthamiana Have Distinct Specificities Toward Engineered Helminth N-Glycans on Recombinant Glycoproteins.
33815445	3	66	theme	helminth	687:694	arg1	composition					705:715	their native helminth N-glycan composition	674:715	their native helminth N-glycan composition	674:715	Recently, pioneering work has shown that helminth glycoproteins can be produced transiently in Nicotiana benthamiana plants while simultaneously mimicking their native helminth N-glycan composition by co-expression of desired glycosyltransferases.
33815445	8	67	theme	major	1613:1617	arg1	targets					1619:1625	major targets	1613:1625	major targets for LDN cleavage	1613:1642	The identification of HEXO2 and HEXO3 as major targets for LDN cleavage will enable a targeted genome editing approach to reduce undesired processing of these N-glycans.
33815445	6	68	theme	N-glycans	1308:1316	arg1	N-glycans					1308:1316	N-glycans	1308:1316	N-glycans	1308:1316	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	6	68	theme	N-glycans	1308:1316	arg1	residues					1296:1303	antennary GalNAc residues	1279:1303	antennary GalNAc residues of N-glycans	1279:1316	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	1	69	theme	worms	190:194	arg1	Secretions					166:175	Secretions	166:175	Secretions of parasitic worms (helminths)	166:206	Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
33815445	0	70	theme	Helminth	117:124	arg1	N-Glycans					126:134	Engineered Helminth N-Glycans	106:134	Engineered Helminth N-Glycans	106:134	β-Hexosaminidases Along the Secretory Pathway of Nicotiana benthamiana Have Distinct Specificities Toward Engineered Helminth N-Glycans on Recombinant Glycoproteins.
33815445	1	71	gly	glycoproteins	254:266	arg1	glycoproteins					254:266	immunomodulatory glycoproteins	237:266	immunomodulatory glycoproteins with the potential to treat inflammatory disorders	237:317	Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
33815445	2	72	link	parasite-derived	492:507	arg1	proteins					509:516	native parasite-derived proteins	485:516	native parasite-derived proteins	485:516	Yet, the identification of single molecules that can be developed into novel biopharmaceuticals is hampered by the limited availability of native parasite-derived proteins.
33815445	3	73	gly	glycoproteins	569:581	arg1	glycoproteins					569:581	helminth glycoproteins	560:581	helminth glycoproteins	560:581	Recently, pioneering work has shown that helminth glycoproteins can be produced transiently in Nicotiana benthamiana plants while simultaneously mimicking their native helminth N-glycan composition by co-expression of desired glycosyltransferases.
33815445	2	74	theme	native	485:490	arg1	proteins					509:516	native parasite-derived proteins	485:516	native parasite-derived proteins	485:516	Yet, the identification of single molecules that can be developed into novel biopharmaceuticals is hampered by the limited availability of native parasite-derived proteins.
33815445	8	75	theme	targeted	1658:1665	arg1	approach					1682:1689	a targeted genome editing approach	1656:1689	a targeted genome editing approach to reduce undesired processing of these N-glycans	1656:1739	The identification of HEXO2 and HEXO3 as major targets for LDN cleavage will enable a targeted genome editing approach to reduce undesired processing of these N-glycans.
33815445	0	76	theme	Secretory	28:36	arg1	Pathway					38:44	the Secretory Pathway	24:44	the Secretory Pathway of Nicotiana benthamiana	24:69	β-Hexosaminidases Along the Secretory Pathway of Nicotiana benthamiana Have Distinct Specificities Toward Engineered Helminth N-Glycans on Recombinant Glycoproteins.
33815445	7	77	theme	family	1414:1419	arg1	member					1395:1400	each member	1390:1400	each member of the HEXO family	1390:1419	Furthermore, we reveal that each member of the HEXO family has a distinct specificity for N-glycan substrates, where HEXO2 has strict β-galactosaminidase activity, whereas HEXO3 cleaves both GlcNAc and GalNAc.
33815445	8	78	theme	editing	1674:1680	arg1	approach					1682:1689	a targeted genome editing approach	1656:1689	a targeted genome editing approach to reduce undesired processing of these N-glycans	1656:1739	The identification of HEXO2 and HEXO3 as major targets for LDN cleavage will enable a targeted genome editing approach to reduce undesired processing of these N-glycans.
33815445	3	79	theme	desired	737:743	arg1	glycosyltransferases					745:764	desired glycosyltransferases	737:764	desired glycosyltransferases	737:764	Recently, pioneering work has shown that helminth glycoproteins can be produced transiently in Nicotiana benthamiana plants while simultaneously mimicking their native helminth N-glycan composition by co-expression of desired glycosyltransferases.
33815445	9	80	with	glycoproteins	1833:1845	arg1	N-glycans					1873:1881	tailor-made helminth N-glycans	1852:1881	tailor-made helminth N-glycans	1852:1881	Effective knockout of these enzymes could allow the production of therapeutically relevant glycoproteins with tailor-made helminth N-glycans in plants.
33815445	0	81	theme	benthamiana	59:69	arg1	Pathway					38:44	the Secretory Pathway	24:44	the Secretory Pathway of Nicotiana benthamiana	24:69	β-Hexosaminidases Along the Secretory Pathway of Nicotiana benthamiana Have Distinct Specificities Toward Engineered Helminth N-Glycans on Recombinant Glycoproteins.
33815445	6	82	theme	responsible	1247:1257	arg1	HEXO2					1220:1224	HEXO2	1220:1224	HEXO2	1220:1224	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	6	82	theme	responsible	1247:1257	arg1	enzymes					1239:1245	enzymes	1239:1245	enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5	1239:1359	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	6	82	theme	responsible	1247:1257	arg1	HEXO3					1230:1234	HEXO3	1230:1234	HEXO3	1230:1234	We identified HEXO2 and HEXO3 as enzymes responsible for the cleavage of antennary GalNAc residues of N-glycans on the model helminth glycoprotein kappa-5.
33815445	2	83	theme	proteins	509:516	arg1	availability					469:480	the limited availability	457:480	the limited availability of native parasite-derived proteins	457:516	Yet, the identification of single molecules that can be developed into novel biopharmaceuticals is hampered by the limited availability of native parasite-derived proteins.
33815445	8	84	theme	undesired	1701:1709	arg1	processing					1711:1720	undesired processing	1701:1720	undesired processing of these N-glycans	1701:1739	The identification of HEXO2 and HEXO3 as major targets for LDN cleavage will enable a targeted genome editing approach to reduce undesired processing of these N-glycans.
33815445	5	85	theme	enzymes	1197:1203	arg1	activity					1179:1186	the biochemical activity	1163:1186	the biochemical activity of these enzymes	1163:1203	In this study, we cloned novel β-hexosaminidase open reading frames from N. benthamiana and characterized the biochemical activity of these enzymes.
33815445	5	86	theme	β-hexosaminidase	1088:1103	arg1	frames					1118:1123	novel β-hexosaminidase open reading frames	1082:1123	novel β-hexosaminidase open reading frames	1082:1123	In this study, we cloned novel β-hexosaminidase open reading frames from N. benthamiana and characterized the biochemical activity of these enzymes.
33815445	5	87	theme	reading	1110:1116	arg1	frames					1118:1123	novel β-hexosaminidase open reading frames	1082:1123	novel β-hexosaminidase open reading frames	1082:1123	In this study, we cloned novel β-hexosaminidase open reading frames from N. benthamiana and characterized the biochemical activity of these enzymes.
33815445	8	88	theme	N-glycans	1731:1739	arg1	processing					1711:1720	undesired processing	1701:1720	undesired processing of these N-glycans	1701:1739	The identification of HEXO2 and HEXO3 as major targets for LDN cleavage will enable a targeted genome editing approach to reduce undesired processing of these N-glycans.
33815445	4	89	theme	complex	900:906	arg1	N-glycans					908:916	complex N-glycans	900:916	complex N-glycans	900:916	However, efficient "helminthization" of N-glycans in plants by glyco-engineering seems to be hampered by the undesired truncation of complex N-glycans by β-N-acetyl-hexosaminidases, in particular when aiming for the synthesis of N-glycans with antennary GalNAcβ1-4GlcNAc (LacdiNAc or LDN).
33815445	0	90	contain	Have	71:74	arg1	β-Hexosaminidases					0:16	β-Hexosaminidases	0:16	β-Hexosaminidases Along the Secretory Pathway of Nicotiana benthamiana	0:69	β-Hexosaminidases Along the Secretory Pathway of Nicotiana benthamiana Have Distinct Specificities Toward Engineered Helminth N-Glycans on Recombinant Glycoproteins.
33815445	0	90	contain	Have	71:74	arg2	Specificities					85:97	Distinct Specificities	76:97	Distinct Specificities Toward Engineered Helminth N-Glycans	76:134	β-Hexosaminidases Along the Secretory Pathway of Nicotiana benthamiana Have Distinct Specificities Toward Engineered Helminth N-Glycans on Recombinant Glycoproteins.
34893270	2	0	from	application	416:426	arg1	engineering					478:488	the tendon tissue engineering	460:488	the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility	460:561	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	1	1	theme	diseases	184:191	arg1	one					145:147	one	145:147	one	145:147	Tendon injury is one of the most common musculoskeletal diseases in the world, severely challenging the public health care system.
34893270	1	1	theme	diseases	184:191	arg1	diseases					184:191	the most common musculoskeletal diseases	152:191	the most common musculoskeletal diseases in the world	152:204	Tendon injury is one of the most common musculoskeletal diseases in the world, severely challenging the public health care system.
34893270	0	2	theme	tendon	107:112	arg1	regeneration					114:125	tendon regeneration	107:125	tendon regeneration	107:125	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds loaded with melatonin facilitate tendon regeneration.
34893270	1	3	from	diseases	184:191	arg1	world					200:204	the world	196:204	the world	196:204	Tendon injury is one of the most common musculoskeletal diseases in the world, severely challenging the public health care system.
34893270	2	4	dep	polycaprolactone	315:330	arg1	i.e.					310:313	i.e.	310:313	i.e.	310:313	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	2	5	from	scaffolds	447:455	arg1	engineering					478:488	the tendon tissue engineering	460:488	the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility	460:561	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	3	6	theme	potential	569:577	arg1	potential					631:639	the potential to promote tendon repair	627:664	the potential to promote tendon repair	627:664	As a potential natural antioxidant, melatonin (MLT) represents the potential to promote tendon repair.
34893270	3	6	theme	potential	569:577	arg1	antioxidant					587:597	a potential natural antioxidant	567:597	a potential natural antioxidant	567:597	As a potential natural antioxidant, melatonin (MLT) represents the potential to promote tendon repair.
34893270	3	7	theme	natural	579:585	arg1	potential					631:639	the potential to promote tendon repair	627:664	the potential to promote tendon repair	627:664	As a potential natural antioxidant, melatonin (MLT) represents the potential to promote tendon repair.
34893270	3	7	theme	natural	579:585	arg1	antioxidant					587:597	a potential natural antioxidant	567:597	a potential natural antioxidant	567:597	As a potential natural antioxidant, melatonin (MLT) represents the potential to promote tendon repair.
34893270	2	8	dep	alginate	366:373	arg1	i.e.					354:357	i.e.	354:357	i.e.	354:357	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	4	9	theme	tendon	751:756	arg1	repair					765:770	tendon injury repair	751:770	tendon injury repair	751:770	Here, we develop an MLT-loaded PCL/ALG composite scaffold that effectively promotes tendon injury repair in vivo and in vitro via a controlled release of MLT, possibly mechanically relying on an antioxidant stress pathway.
34893270	4	10	theme	MLT-loaded	687:696	arg1	scaffold					716:723	an MLT-loaded PCL/ALG composite scaffold	684:723	an MLT-loaded PCL/ALG composite scaffold that effectively promotes tendon injury repair in vivo and in vitro via a controlled release of MLT, possibly mechanically relying on an antioxidant stress pathway	684:887	Here, we develop an MLT-loaded PCL/ALG composite scaffold that effectively promotes tendon injury repair in vivo and in vitro via a controlled release of MLT, possibly mechanically relying on an antioxidant stress pathway.
34893270	2	11	from	engineering	478:488	arg1	application					416:426	application	416:426	application	416:426	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	2	11	from	engineering	478:488	arg1	development					400:410	development	400:410	development	400:410	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	5	12	from	significance	942:953	arg1	engineering					976:986	the tendon tissue engineering	958:986	the tendon tissue engineering	958:986	This biomimetic composite scaffold will be of great significance in the tendon tissue engineering.
34893270	0	13	theme	Biomimetic	0:9	arg1	scaffolds					64:72	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds	0:72	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds loaded with melatonin	0:94	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds loaded with melatonin facilitate tendon regeneration.
34893270	4	14	theme	controlled	799:808	arg1	release					810:816	a controlled release	797:816	a controlled release of MLT	797:823	Here, we develop an MLT-loaded PCL/ALG composite scaffold that effectively promotes tendon injury repair in vivo and in vitro via a controlled release of MLT, possibly mechanically relying on an antioxidant stress pathway.
34893270	0	15	theme	multilayer	11:20	arg1	scaffolds					64:72	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds	0:72	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds loaded with melatonin	0:94	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds loaded with melatonin facilitate tendon regeneration.
34893270	4	16	theme	stress	874:879	arg1	pathway					881:887	an antioxidant stress pathway	859:887	an antioxidant stress pathway	859:887	Here, we develop an MLT-loaded PCL/ALG composite scaffold that effectively promotes tendon injury repair in vivo and in vitro via a controlled release of MLT, possibly mechanically relying on an antioxidant stress pathway.
34893270	2	17	dep	materials	299:307	arg1	polycaprolactone					315:330	polycaprolactone	315:330	polycaprolactone (PCL)	315:336	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	2	17	dep	materials	299:307	arg1	PCL					333:335	PCL	333:335	PCL	333:335	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	2	18	theme	scaffolds	447:455	arg1	application					416:426	application	416:426	application	416:426	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	2	18	theme	scaffolds	447:455	arg1	development					400:410	development	400:410	development	400:410	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	4	19	theme	antioxidant	862:872	arg1	pathway					881:887	an antioxidant stress pathway	859:887	an antioxidant stress pathway	859:887	Here, we develop an MLT-loaded PCL/ALG composite scaffold that effectively promotes tendon injury repair in vivo and in vitro via a controlled release of MLT, possibly mechanically relying on an antioxidant stress pathway.
34893270	1	20	theme	Tendon	128:133	arg1	injury					135:140	Tendon injury	128:140	Tendon injury	128:140	Tendon injury is one of the most common musculoskeletal diseases in the world, severely challenging the public health care system.
34893270	5	21	theme	biomimetic	895:904	arg1	scaffold					916:923	This biomimetic composite scaffold	890:923	This biomimetic composite scaffold	890:923	This biomimetic composite scaffold will be of great significance in the tendon tissue engineering.
34893270	2	22	theme	composite	437:445	arg1	scaffolds					447:455	smart composite scaffolds	431:455	smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility	431:561	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	5	23	theme	tissue	969:974	arg1	engineering					976:986	the tendon tissue engineering	958:986	the tendon tissue engineering	958:986	This biomimetic composite scaffold will be of great significance in the tendon tissue engineering.
34893270	2	24	theme	smart	431:435	arg1	scaffolds					447:455	smart composite scaffolds	431:455	smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility	431:561	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	5	25	theme	tendon	962:967	arg1	engineering					976:986	the tendon tissue engineering	958:986	the tendon tissue engineering	958:986	This biomimetic composite scaffold will be of great significance in the tendon tissue engineering.
34893270	4	26	theme	composite	706:714	arg1	scaffold					716:723	an MLT-loaded PCL/ALG composite scaffold	684:723	an MLT-loaded PCL/ALG composite scaffold that effectively promotes tendon injury repair in vivo and in vitro via a controlled release of MLT, possibly mechanically relying on an antioxidant stress pathway	684:887	Here, we develop an MLT-loaded PCL/ALG composite scaffold that effectively promotes tendon injury repair in vivo and in vitro via a controlled release of MLT, possibly mechanically relying on an antioxidant stress pathway.
34893270	2	27	theme	Electrospinning	259:273	arg1	technique					275:283	Electrospinning technique	259:283	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG))	259:380	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	1	28	theme	public	232:237	arg1	system					251:256	the public health care system	228:256	the public health care system	228:256	Tendon injury is one of the most common musculoskeletal diseases in the world, severely challenging the public health care system.
34893270	2	29	theme	tissue	471:476	arg1	engineering					478:488	the tendon tissue engineering	460:488	the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility	460:561	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	0	30	theme	hydrogel	55:62	arg1	scaffolds					64:72	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds	0:72	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds loaded with melatonin	0:94	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds loaded with melatonin facilitate tendon regeneration.
34893270	0	31	theme	alginate	46:53	arg1	scaffolds					64:72	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds	0:72	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds loaded with melatonin	0:94	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds loaded with melatonin facilitate tendon regeneration.
34893270	1	32	theme	health	239:244	arg1	system					251:256	the public health care system	228:256	the public health care system	228:256	Tendon injury is one of the most common musculoskeletal diseases in the world, severely challenging the public health care system.
34893270	2	33	theme	tendon	464:469	arg1	engineering					478:488	the tendon tissue engineering	460:488	the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility	460:561	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	5	34	theme	composite	906:914	arg1	scaffold					916:923	This biomimetic composite scaffold	890:923	This biomimetic composite scaffold	890:923	This biomimetic composite scaffold will be of great significance in the tendon tissue engineering.
34893270	3	35	theme	tendon	652:657	arg1	repair					659:664	tendon repair	652:664	tendon repair	652:664	As a potential natural antioxidant, melatonin (MLT) represents the potential to promote tendon repair.
34893270	2	36	theme	sodium	359:364	arg1	ALG					376:378	ALG	376:378	ALG	376:378	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	2	36	theme	sodium	359:364	arg1	alginate					366:373	sodium alginate	359:373	sodium alginate (ALG)	359:379	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	5	37	theme	great	936:940	arg1	significance					942:953	great significance	936:953	great significance	936:953	This biomimetic composite scaffold will be of great significance in the tendon tissue engineering.
34893270	2	38	dep	development	400:410	arg1	the					396:398	the	396:398	the	396:398	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	4	39	theme	injury	758:763	arg1	repair					765:770	tendon injury repair	751:770	tendon injury repair	751:770	Here, we develop an MLT-loaded PCL/ALG composite scaffold that effectively promotes tendon injury repair in vivo and in vitro via a controlled release of MLT, possibly mechanically relying on an antioxidant stress pathway.
34893270	1	40	theme	care	246:249	arg1	system					251:256	the public health care system	228:256	the public health care system	228:256	Tendon injury is one of the most common musculoskeletal diseases in the world, severely challenging the public health care system.
34893270	2	41	theme	polymer	291:297	arg1	materials					299:307	polymer materials	291:307	polymer materials (i.e. polycaprolactone (PCL))	291:337	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	4	42	theme	PCL/ALG	698:704	arg1	scaffold					716:723	an MLT-loaded PCL/ALG composite scaffold	684:723	an MLT-loaded PCL/ALG composite scaffold that effectively promotes tendon injury repair in vivo and in vitro via a controlled release of MLT, possibly mechanically relying on an antioxidant stress pathway	684:887	Here, we develop an MLT-loaded PCL/ALG composite scaffold that effectively promotes tendon injury repair in vivo and in vitro via a controlled release of MLT, possibly mechanically relying on an antioxidant stress pathway.
34893270	2	43	theme	mechanical	520:529	arg1	properties					531:540	mechanical properties	520:540	mechanical properties	520:540	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	4	44	theme	MLT	821:823	arg1	release					810:816	a controlled release	797:816	a controlled release of MLT	797:823	Here, we develop an MLT-loaded PCL/ALG composite scaffold that effectively promotes tendon injury repair in vivo and in vitro via a controlled release of MLT, possibly mechanically relying on an antioxidant stress pathway.
34893270	2	45	from	development	400:410	arg1	engineering					478:488	the tendon tissue engineering	460:488	the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility	460:561	Electrospinning technique using polymer materials (i.e. polycaprolactone (PCL)) and hydrogels (i.e. sodium alginate (ALG)) contribute to the development and application of smart composite scaffolds in the tendon tissue engineering by advantageously integrating mechanical properties and biocompatibility.
34893270	1	46	theme	common	161:166	arg1	diseases					184:191	the most common musculoskeletal diseases	152:191	the most common musculoskeletal diseases in the world	152:204	Tendon injury is one of the most common musculoskeletal diseases in the world, severely challenging the public health care system.
34893270	0	47	theme	polycaprolactone/sodium	22:44	arg1	scaffolds					64:72	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds	0:72	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds loaded with melatonin	0:94	Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds loaded with melatonin facilitate tendon regeneration.
34893270	1	48	theme	musculoskeletal	168:182	arg1	diseases					184:191	the most common musculoskeletal diseases	152:191	the most common musculoskeletal diseases in the world	152:204	Tendon injury is one of the most common musculoskeletal diseases in the world, severely challenging the public health care system.
32218143	5	0	theme	DON-polluted	845:856	arg1	CSL					858:860	DON-polluted CSL	845:860	DON-polluted CSL	845:860	Results showed that 5 g of microspheres reacted with 5 mL of DON-polluted CSL for 5 min, the microspheres can be recycled 155 times, and the maximum DON adsorption for the microspheres was 2.34 μg/mL.
32218143	7	1	theme	hydrogen	1237:1244	arg1	bonding					1246:1252	hydrogen bonding	1237:1252	hydrogen bonding	1237:1252	The mechanism for physical adsorption and hydrogen bonding was analyzed by scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR).
32218143	2	2	theme	contaminated	307:318	arg1	feed					320:323	contaminated feed	307:323	contaminated feed	307:323	Approaches using mycotoxin adsorbents are key to decreasing mycotoxin carryover from contaminated feed to animals.
32218143	0	3	from	Adsorption	0:9	arg1	CSL					59:61	CSL	59:61	CSL	59:61	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC Loaded with Calcium.
32218143	0	3	from	Adsorption	0:9	arg1	Liquor					51:56	Corn Steep Liquor	40:56	Corn Steep Liquor (CSL)	40:62	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC Loaded with Calcium.
32218143	9	4	theme	microsphere	1507:1517	arg1	absorbents					1519:1528	microsphere absorbents	1507:1528	microsphere absorbents	1507:1528	Therefore, we suggest that using microsphere absorbents would be a possible way to address DON-contaminated CSL issues in animal feed.
32218143	1	5	from	occurrence	125:134	arg1	feed					170:173	animal feed	163:173	animal feed	163:173	The occurrence of deoxynivalenol (DON) in animal feed is a serious issue for the livestock industry.
32218143	3	6	theme	emulsification	508:521	arg1	process					523:529	an emulsification process	505:529	an emulsification process	505:529	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	7	7	theme	electron	1279:1286	arg1	microscopy					1288:1297	scanning electron microscopy	1270:1297	scanning electron microscopy (SEM)	1270:1303	The mechanism for physical adsorption and hydrogen bonding was analyzed by scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR).
32218143	7	7	theme	electron	1279:1286	arg1	SEM					1300:1302	SEM	1300:1302	SEM	1300:1302	The mechanism for physical adsorption and hydrogen bonding was analyzed by scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR).
32218143	1	8	theme	livestock	202:210	arg1	industry					212:219	the livestock industry	198:219	the livestock industry	198:219	The occurrence of deoxynivalenol (DON) in animal feed is a serious issue for the livestock industry.
32218143	4	9	theme	reaction	719:726	arg1	times					728:732	reaction times	719:732	reaction times	719:732	Batch experiments were conducted under different experimental conditions: CSL volumes, reaction times, desorption times, and microsphere recyclability.
32218143	7	10	dep	Fourier	1309:1315	arg1	transform					1317:1325	transform	1317:1325	transform infrared spectrometry (FTIR)	1317:1354	The mechanism for physical adsorption and hydrogen bonding was analyzed by scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR).
32218143	0	11	theme	Microsphere	71:81	arg1	SA/CMC					93:98	the Microsphere Adsorbent SA/CMC	67:98	the Microsphere Adsorbent SA/CMC	67:98	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC Loaded with Calcium.
32218143	4	12	theme	desorption	735:744	arg1	times					746:750	desorption times	735:750	desorption times	735:750	Batch experiments were conducted under different experimental conditions: CSL volumes, reaction times, desorption times, and microsphere recyclability.
32218143	7	13	theme	physical	1213:1220	arg1	adsorption					1222:1231	physical adsorption	1213:1231	physical adsorption	1213:1231	The mechanism for physical adsorption and hydrogen bonding was analyzed by scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR).
32218143	5	14	theme	microspheres	811:822	arg1	g					806:806	5 g	804:806	5 g of microspheres	804:822	Results showed that 5 g of microspheres reacted with 5 mL of DON-polluted CSL for 5 min, the microspheres can be recycled 155 times, and the maximum DON adsorption for the microspheres was 2.34 μg/mL.
32218143	2	15	from	feed	320:323	arg1	carryover					292:300	mycotoxin carryover	282:300	mycotoxin carryover from contaminated feed to animals	282:334	Approaches using mycotoxin adsorbents are key to decreasing mycotoxin carryover from contaminated feed to animals.
32218143	1	16	theme	deoxynivalenol	139:152	arg1	issue					188:192	a serious issue	178:192	a serious issue for the livestock industry	178:219	The occurrence of deoxynivalenol (DON) in animal feed is a serious issue for the livestock industry.
32218143	1	16	theme	deoxynivalenol	139:152	arg1	occurrence					125:134	The occurrence	121:134	The occurrence of deoxynivalenol (DON) in animal feed	121:173	The occurrence of deoxynivalenol (DON) in animal feed is a serious issue for the livestock industry.
32218143	4	17	theme	CSL	706:708	arg1	volumes					710:716	CSL volumes	706:716	CSL volumes	706:716	Batch experiments were conducted under different experimental conditions: CSL volumes, reaction times, desorption times, and microsphere recyclability.
32218143	6	18	from	DON	1101:1103	arg1	water					1122:1126	the deionized water	1108:1126	the deionized water	1108:1126	During recycling, microspheres were regenerated by deionized water every time; after the microspheres were cleaned, DON in the deionized water was degraded by sodium hydroxide (NaOH) at 70 °C for 1 h at pH 12.
32218143	6	19	theme	deionized	1112:1120	arg1	water					1122:1126	the deionized water	1108:1126	the deionized water	1108:1126	During recycling, microspheres were regenerated by deionized water every time; after the microspheres were cleaned, DON in the deionized water was degraded by sodium hydroxide (NaOH) at 70 °C for 1 h at pH 12.
32218143	8	20	theme	first	1399:1403	arg1	report					1405:1410	the first report	1395:1410	the first report showing that the microsphere adsorbent SA/CMC-Ca adsorbs DON	1395:1471	To the best of our knowledge, this is the first report showing that the microsphere adsorbent SA/CMC-Ca adsorbs DON.
32218143	8	20	theme	first	1399:1403	arg1	this					1387:1390	this	1387:1390	this	1387:1390	To the best of our knowledge, this is the first report showing that the microsphere adsorbent SA/CMC-Ca adsorbs DON.
32218143	9	21	theme	possible	1541:1548	arg1	way					1550:1552	a possible way	1539:1552	a possible way to address DON-contaminated CSL issues in animal feed	1539:1606	Therefore, we suggest that using microsphere absorbents would be a possible way to address DON-contaminated CSL issues in animal feed.
32218143	3	22	theme	adsorbent	383:391	arg1	microsphere					371:381	a novel functional microsphere adsorbent	352:391	a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca)	352:487	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	5	23	theme	maximum	925:931	arg1	μg/mL					978:982	2.34 μg/mL	973:982	2.34 μg/mL	973:982	Results showed that 5 g of microspheres reacted with 5 mL of DON-polluted CSL for 5 min, the microspheres can be recycled 155 times, and the maximum DON adsorption for the microspheres was 2.34 μg/mL.
32218143	5	23	theme	maximum	925:931	arg1	adsorption					937:946	the maximum DON adsorption	921:946	the maximum DON adsorption for the microspheres	921:967	Results showed that 5 g of microspheres reacted with 5 mL of DON-polluted CSL for 5 min, the microspheres can be recycled 155 times, and the maximum DON adsorption for the microspheres was 2.34 μg/mL.
32218143	7	24	theme	scanning	1270:1277	arg1	microscopy					1288:1297	scanning electron microscopy	1270:1297	scanning electron microscopy (SEM)	1270:1303	The mechanism for physical adsorption and hydrogen bonding was analyzed by scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR).
32218143	7	24	theme	scanning	1270:1277	arg1	SEM					1300:1302	SEM	1300:1302	SEM	1300:1302	The mechanism for physical adsorption and hydrogen bonding was analyzed by scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR).
32218143	3	25	theme	sodium	440:445	arg1	composite					447:455	an alginate/carboxymethyl cellulose sodium composite	404:455	an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca)	404:487	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	0	26	theme	Deoxynivalenol	14:27	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC	0:98	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC Loaded with Calcium.
32218143	0	27	theme	Adsorbent	83:91	arg1	SA/CMC					93:98	the Microsphere Adsorbent SA/CMC	67:98	the Microsphere Adsorbent SA/CMC	67:98	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC Loaded with Calcium.
32218143	5	28	theme	CSL	858:860	arg1	mL					839:840	5 mL	837:840	5 mL of DON-polluted CSL for 5 min	837:870	Results showed that 5 g of microspheres reacted with 5 mL of DON-polluted CSL for 5 min, the microspheres can be recycled 155 times, and the maximum DON adsorption for the microspheres was 2.34 μg/mL.
32218143	3	29	theme	novel	354:358	arg1	microsphere					371:381	a novel functional microsphere adsorbent	352:391	a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca)	352:487	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	8	30	theme	microsphere	1429:1439	arg1	SA/CMC-Ca					1451:1459	the microsphere adsorbent SA/CMC-Ca	1425:1459	the microsphere adsorbent SA/CMC-Ca	1425:1459	To the best of our knowledge, this is the first report showing that the microsphere adsorbent SA/CMC-Ca adsorbs DON.
32218143	3	31	theme	alginate/carboxymethyl	407:428	arg1	composite					447:455	an alginate/carboxymethyl cellulose sodium composite	404:455	an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca)	404:487	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	3	32	theme	steep	564:568	arg1	CSL					578:580	CSL	578:580	CSL	578:580	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	3	32	theme	steep	564:568	arg1	liquor					570:575	polluted corn steep liquor	550:575	polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL	550:629	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	3	33	from	liquor	570:575	arg1	DON					541:543	DON	541:543	DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL	541:629	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	1	34	theme	animal	163:168	arg1	feed					170:173	animal feed	163:173	animal feed	163:173	The occurrence of deoxynivalenol (DON) in animal feed is a serious issue for the livestock industry.
32218143	3	35	theme	functional	360:369	arg1	microsphere					371:381	a novel functional microsphere adsorbent	352:391	a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca)	352:487	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	7	36	dep	transform	1317:1325	arg1	infrared					1327:1334	infrared	1327:1334	transform infrared spectrometry (FTIR)	1317:1354	The mechanism for physical adsorption and hydrogen bonding was analyzed by scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR).
32218143	9	37	theme	DON-contaminated	1565:1580	arg1	issues					1586:1591	DON-contaminated CSL issues	1565:1591	DON-contaminated CSL issues in animal feed	1565:1606	Therefore, we suggest that using microsphere absorbents would be a possible way to address DON-contaminated CSL issues in animal feed.
32218143	0	38	from	Liquor	51:56	arg1	Deoxynivalenol					14:27	Deoxynivalenol	14:27	Deoxynivalenol (DON) from Corn Steep Liquor (CSL)	14:62	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC Loaded with Calcium.
32218143	0	38	from	Liquor	51:56	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC	0:98	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC Loaded with Calcium.
32218143	0	38	from	Liquor	51:56	arg1	DON					30:32	DON	30:32	DON	30:32	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC Loaded with Calcium.
32218143	1	39	theme	serious	180:186	arg1	issue					188:192	a serious issue	178:192	a serious issue for the livestock industry	178:219	The occurrence of deoxynivalenol (DON) in animal feed is a serious issue for the livestock industry.
32218143	1	39	theme	serious	180:186	arg1	occurrence					125:134	The occurrence	121:134	The occurrence of deoxynivalenol (DON) in animal feed	121:173	The occurrence of deoxynivalenol (DON) in animal feed is a serious issue for the livestock industry.
32218143	6	40	dep	water	1046:1050	arg1	time					1058:1061	every time	1052:1061	deionized water every time	1036:1061	During recycling, microspheres were regenerated by deionized water every time; after the microspheres were cleaned, DON in the deionized water was degraded by sodium hydroxide (NaOH) at 70 °C for 1 h at pH 12.
32218143	3	41	theme	cellulose	430:438	arg1	composite					447:455	an alginate/carboxymethyl cellulose sodium composite	404:455	an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca)	404:487	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	0	42	theme	Corn	40:43	arg1	CSL					59:61	CSL	59:61	CSL	59:61	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC Loaded with Calcium.
32218143	0	42	theme	Corn	40:43	arg1	Liquor					51:56	Corn Steep Liquor	40:56	Corn Steep Liquor (CSL)	40:62	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC Loaded with Calcium.
32218143	9	43	theme	CSL	1582:1584	arg1	issues					1586:1591	DON-contaminated CSL issues	1565:1591	DON-contaminated CSL issues in animal feed	1565:1606	Therefore, we suggest that using microsphere absorbents would be a possible way to address DON-contaminated CSL issues in animal feed.
32218143	3	44	theme	polluted	550:557	arg1	CSL					578:580	CSL	578:580	CSL	578:580	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	3	44	theme	polluted	550:557	arg1	liquor					570:575	polluted corn steep liquor	550:575	polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL	550:629	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	4	45	theme	different	671:679	arg1	conditions					694:703	different experimental conditions	671:703	different experimental conditions	671:703	Batch experiments were conducted under different experimental conditions: CSL volumes, reaction times, desorption times, and microsphere recyclability.
32218143	8	46	theme	adsorbent	1441:1449	arg1	SA/CMC-Ca					1451:1459	the microsphere adsorbent SA/CMC-Ca	1425:1459	the microsphere adsorbent SA/CMC-Ca	1425:1459	To the best of our knowledge, this is the first report showing that the microsphere adsorbent SA/CMC-Ca adsorbs DON.
32218143	3	47	theme	μg/mL	625:629	arg1	concentration					603:615	a concentration	601:615	a concentration of 3.60 μg/mL	601:629	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	3	48	theme	corn	559:562	arg1	CSL					578:580	CSL	578:580	CSL	578:580	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	3	48	theme	corn	559:562	arg1	liquor					570:575	polluted corn steep liquor	550:575	polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL	550:629	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	6	49	from	pH	1188:1189	arg1	h					1183:1183	1 h	1181:1183	1 h at pH 12	1181:1192	During recycling, microspheres were regenerated by deionized water every time; after the microspheres were cleaned, DON in the deionized water was degraded by sodium hydroxide (NaOH) at 70 °C for 1 h at pH 12.
32218143	6	50	theme	sodium	1144:1149	arg1	NaOH					1162:1165	NaOH	1162:1165	NaOH	1162:1165	During recycling, microspheres were regenerated by deionized water every time; after the microspheres were cleaned, DON in the deionized water was degraded by sodium hydroxide (NaOH) at 70 °C for 1 h at pH 12.
32218143	6	50	theme	sodium	1144:1149	arg1	hydroxide					1151:1159	sodium hydroxide	1144:1159	sodium hydroxide (NaOH) at 70 °C for 1 h at pH 12	1144:1192	During recycling, microspheres were regenerated by deionized water every time; after the microspheres were cleaned, DON in the deionized water was degraded by sodium hydroxide (NaOH) at 70 °C for 1 h at pH 12.
32218143	2	51	theme	mycotoxin	282:290	arg1	carryover					292:300	mycotoxin carryover	282:300	mycotoxin carryover from contaminated feed to animals	282:334	Approaches using mycotoxin adsorbents are key to decreasing mycotoxin carryover from contaminated feed to animals.
32218143	6	52	from	°C	1174:1175	arg1	NaOH					1162:1165	NaOH	1162:1165	NaOH	1162:1165	During recycling, microspheres were regenerated by deionized water every time; after the microspheres were cleaned, DON in the deionized water was degraded by sodium hydroxide (NaOH) at 70 °C for 1 h at pH 12.
32218143	6	52	from	°C	1174:1175	arg1	hydroxide					1151:1159	sodium hydroxide	1144:1159	sodium hydroxide (NaOH) at 70 °C for 1 h at pH 12	1144:1192	During recycling, microspheres were regenerated by deionized water every time; after the microspheres were cleaned, DON in the deionized water was degraded by sodium hydroxide (NaOH) at 70 °C for 1 h at pH 12.
32218143	9	53	theme	animal	1596:1601	arg1	feed					1603:1606	animal feed	1596:1606	animal feed	1596:1606	Therefore, we suggest that using microsphere absorbents would be a possible way to address DON-contaminated CSL issues in animal feed.
32218143	2	54	theme	mycotoxin	239:247	arg1	adsorbents					249:258	mycotoxin adsorbents	239:258	mycotoxin adsorbents	239:258	Approaches using mycotoxin adsorbents are key to decreasing mycotoxin carryover from contaminated feed to animals.
32218143	4	55	theme	experimental	681:692	arg1	conditions					694:703	different experimental conditions	671:703	different experimental conditions	671:703	Batch experiments were conducted under different experimental conditions: CSL volumes, reaction times, desorption times, and microsphere recyclability.
32218143	4	56	theme	microsphere	757:767	arg1	recyclability					769:781	microsphere recyclability	757:781	microsphere recyclability	757:781	Batch experiments were conducted under different experimental conditions: CSL volumes, reaction times, desorption times, and microsphere recyclability.
32218143	6	57	theme	deionized	1036:1044	arg1	water					1046:1050	deionized water every time	1036:1061	deionized water every time	1036:1061	During recycling, microspheres were regenerated by deionized water every time; after the microspheres were cleaned, DON in the deionized water was degraded by sodium hydroxide (NaOH) at 70 °C for 1 h at pH 12.
32218143	3	58	contain	containing	583:592	arg2	DON					594:596	DON	594:596	DON	594:596	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	3	58	contain	containing	583:592	arg1	liquor					570:575	polluted corn steep liquor	550:575	polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL	550:629	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	3	58	contain	containing	583:592	arg1	CSL					578:580	CSL	578:580	CSL	578:580	In this paper, a novel functional microsphere adsorbent comprising an alginate/carboxymethyl cellulose sodium composite loaded with calcium (SA/CMC-Ca) was prepared by an emulsification process to adsorb DON from polluted corn steep liquor (CSL) containing DON at a concentration of 3.60 μg/mL.
32218143	0	59	theme	Steep	45:49	arg1	CSL					59:61	CSL	59:61	CSL	59:61	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC Loaded with Calcium.
32218143	0	59	theme	Steep	45:49	arg1	Liquor					51:56	Corn Steep Liquor	40:56	Corn Steep Liquor (CSL)	40:62	Adsorption of Deoxynivalenol (DON) from Corn Steep Liquor (CSL) by the Microsphere Adsorbent SA/CMC Loaded with Calcium.
32218143	5	60	theme	DON	933:935	arg1	μg/mL					978:982	2.34 μg/mL	973:982	2.34 μg/mL	973:982	Results showed that 5 g of microspheres reacted with 5 mL of DON-polluted CSL for 5 min, the microspheres can be recycled 155 times, and the maximum DON adsorption for the microspheres was 2.34 μg/mL.
32218143	5	60	theme	DON	933:935	arg1	adsorption					937:946	the maximum DON adsorption	921:946	the maximum DON adsorption for the microspheres	921:967	Results showed that 5 g of microspheres reacted with 5 mL of DON-polluted CSL for 5 min, the microspheres can be recycled 155 times, and the maximum DON adsorption for the microspheres was 2.34 μg/mL.
32218143	4	61	theme	Batch	632:636	arg1	experiments					638:648	Batch experiments	632:648	Batch experiments	632:648	Batch experiments were conducted under different experimental conditions: CSL volumes, reaction times, desorption times, and microsphere recyclability.
32218143	9	62	from	issues	1586:1591	arg1	feed					1603:1606	animal feed	1596:1606	animal feed	1596:1606	Therefore, we suggest that using microsphere absorbents would be a possible way to address DON-contaminated CSL issues in animal feed.
33385446	8	0	theme	drug-loaded	1514:1524	arg1	hydrogels					1526:1534	the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels	1464:1534	the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels	1464:1534	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	4	1	theme	molecular	779:787	arg1	weight					789:794	molecular weight	779:794	molecular weight	779:794	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	8	2	theme	antibacterial	1491:1503	arg1	efficacy					1505:1512	high antibacterial efficacy	1486:1512	high antibacterial efficacy	1486:1512	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	4	3	from	influence	857:865	arg1	morphologies					913:924	morphologies	913:924	morphologies	913:924	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	4	3	from	influence	857:865	arg1	yield					883:887	gel fraction yield	870:887	gel fraction yield	870:887	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	4	3	from	influence	857:865	arg1	properties					898:907	thermal properties	890:907	thermal properties	890:907	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	3	4	theme	reduced	715:721	arg1	pressure					723:730	reduced pressure	715:730	reduced pressure	715:730	For this purpose, the simultaneous partial crosslinking and functionalization of dextran with phosphoric acid in a urea melt under reduced pressure were studied.
33385446	1	5	theme	chemical	293:300	arg1	carriers					335:342	great candidate carriers	319:342	great candidate carriers for drug delivery	319:360	Polyelectrolyte complexes (PECs) are spontaneously formed by mixing oppositely charged polyelectrolyte solutions without the use of organic solvents and chemical crosslinkers are great candidate carriers for drug delivery.
33385446	1	5	theme	chemical	293:300	arg1	crosslinkers					302:313	chemical crosslinkers	293:313	chemical crosslinkers	293:313	Polyelectrolyte complexes (PECs) are spontaneously formed by mixing oppositely charged polyelectrolyte solutions without the use of organic solvents and chemical crosslinkers are great candidate carriers for drug delivery.
33385446	0	6	theme	biomedical	115:124	arg1	applications					126:137	biomedical applications	115:137	biomedical applications	115:137	Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications.
33385446	3	7	theme	simultaneous	606:617	arg1	crosslinking					627:638	simultaneous partial crosslinking	606:638	simultaneous partial crosslinking	606:638	For this purpose, the simultaneous partial crosslinking and functionalization of dextran with phosphoric acid in a urea melt under reduced pressure were studied.
33385446	7	8	theme	drug-loaded	1228:1238	arg1	hydrogels					1240:1248	The drug-loaded hydrogels	1224:1248	The drug-loaded hydrogels	1224:1248	The drug-loaded hydrogels showed antimicrobial activity against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus.
33385446	3	9	theme	partial	619:625	arg1	crosslinking					627:638	simultaneous partial crosslinking	606:638	simultaneous partial crosslinking	606:638	For this purpose, the simultaneous partial crosslinking and functionalization of dextran with phosphoric acid in a urea melt under reduced pressure were studied.
33385446	4	10	theme	dextran	799:805	arg1	phosphate					807:815	dextran phosphate	799:815	dextran phosphate	799:815	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	2	11	theme	polyelectrolyte	399:413	arg1	complexes					415:423	biodegradable antimicrobial polyelectrolyte complexes	371:423	biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin	371:483	Herein, biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin were developed and characterized in order to assess their suitability for biomedical applications.
33385446	6	12	theme	sustained-release	1200:1216	arg1	time					1218:1221	long sustained-release time	1195:1221	long sustained-release time	1195:1221	The release of drug from cefazolin-loaded DPCS hydrogels was through non-Fickian diffusion and displayed long sustained-release time.
33385446	4	13	dep	content	767:773	arg1	The					746:748	The	746:748	The	746:748	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	4	14	theme	functional	750:759	arg1	content					767:773	functional group content	750:773	functional group content	750:773	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	8	15	theme	hydrogels	1526:1534	arg1	biocompatibility					1444:1459	biocompatibility	1444:1459	biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels	1444:1534	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	5	16	theme	good	983:986	arg1	biocompatibility					997:1012	good in vitro biocompatibility	983:1012	good in vitro biocompatibility	983:1012	The stoichiometric PECs of DPCS showed good in vitro biocompatibility, pH sensitivity and biodegradability depending on the hydrogel composition.
33385446	0	17	link	crosslinked	66:76	arg1	phosphate					86:94	partially crosslinked dextran phosphate	56:94	partially crosslinked dextran phosphate	56:94	Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications.
33385446	5	18	theme	hydrogel	1068:1075	arg1	composition					1077:1087	the hydrogel composition	1064:1087	the hydrogel composition	1064:1087	The stoichiometric PECs of DPCS showed good in vitro biocompatibility, pH sensitivity and biodegradability depending on the hydrogel composition.
33385446	6	19	theme	long	1195:1198	arg1	time					1218:1221	long sustained-release time	1195:1221	long sustained-release time	1195:1221	The release of drug from cefazolin-loaded DPCS hydrogels was through non-Fickian diffusion and displayed long sustained-release time.
33385446	8	20	theme	physiological	1399:1411	arg1	conditions					1413:1422	physiological conditions	1399:1422	physiological conditions	1399:1422	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	0	21	theme	polyelectrolyte	14:28	arg1	complexes					30:38	Biodegradable polyelectrolyte complexes	0:38	Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications	0:137	Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications.
33385446	4	22	theme	hydrogels	933:941	arg1	influence					857:865	their influence	851:865	their influence on gel fraction yield, thermal properties and morphologies of the hydrogels	851:941	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	5	23	theme	pH	1015:1016	arg1	sensitivity					1018:1028	pH sensitivity	1015:1028	pH sensitivity	1015:1028	The stoichiometric PECs of DPCS showed good in vitro biocompatibility, pH sensitivity and biodegradability depending on the hydrogel composition.
33385446	3	24	with	crosslinking	627:638	arg1	acid					689:692	phosphoric acid	678:692	phosphoric acid in a urea melt under reduced pressure	678:730	For this purpose, the simultaneous partial crosslinking and functionalization of dextran with phosphoric acid in a urea melt under reduced pressure were studied.
33385446	2	25	theme	phosphate	447:455	arg1	complexes					415:423	biodegradable antimicrobial polyelectrolyte complexes	371:423	biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin	371:483	Herein, biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin were developed and characterized in order to assess their suitability for biomedical applications.
33385446	0	26	theme	Biodegradable	0:12	arg1	complexes					30:38	Biodegradable polyelectrolyte complexes	0:38	Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications	0:137	Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications.
33385446	1	27	theme	great	319:323	arg1	carriers					335:342	great candidate carriers	319:342	great candidate carriers for drug delivery	319:360	Polyelectrolyte complexes (PECs) are spontaneously formed by mixing oppositely charged polyelectrolyte solutions without the use of organic solvents and chemical crosslinkers are great candidate carriers for drug delivery.
33385446	1	27	theme	great	319:323	arg1	crosslinkers					302:313	chemical crosslinkers	293:313	chemical crosslinkers	293:313	Polyelectrolyte complexes (PECs) are spontaneously formed by mixing oppositely charged polyelectrolyte solutions without the use of organic solvents and chemical crosslinkers are great candidate carriers for drug delivery.
33385446	8	28	theme	presented	1551:1559	arg1	materials					1561:1569	the presented materials	1547:1569	the presented materials	1547:1569	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	1	29	theme	charged	219:225	arg1	solutions					243:251	oppositely charged polyelectrolyte solutions	208:251	oppositely charged polyelectrolyte solutions	208:251	Polyelectrolyte complexes (PECs) are spontaneously formed by mixing oppositely charged polyelectrolyte solutions without the use of organic solvents and chemical crosslinkers are great candidate carriers for drug delivery.
33385446	3	30	with	functionalization	644:660	arg1	acid					689:692	phosphoric acid	678:692	phosphoric acid in a urea melt under reduced pressure	678:730	For this purpose, the simultaneous partial crosslinking and functionalization of dextran with phosphoric acid in a urea melt under reduced pressure were studied.
33385446	1	31	theme	candidate	325:333	arg1	carriers					335:342	great candidate carriers	319:342	great candidate carriers for drug delivery	319:360	Polyelectrolyte complexes (PECs) are spontaneously formed by mixing oppositely charged polyelectrolyte solutions without the use of organic solvents and chemical crosslinkers are great candidate carriers for drug delivery.
33385446	1	31	theme	candidate	325:333	arg1	crosslinkers					302:313	chemical crosslinkers	293:313	chemical crosslinkers	293:313	Polyelectrolyte complexes (PECs) are spontaneously formed by mixing oppositely charged polyelectrolyte solutions without the use of organic solvents and chemical crosslinkers are great candidate carriers for drug delivery.
33385446	8	32	theme	DPCS	1477:1480	arg1	hydrogels					1526:1534	the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels	1464:1534	the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels	1464:1534	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	8	33	theme	biomedical	1587:1596	arg1	applications					1598:1609	biomedical applications	1587:1609	biomedical applications	1587:1609	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	4	34	theme	thermal	890:896	arg1	yield					883:887	gel fraction yield	870:887	gel fraction yield	870:887	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	4	34	theme	thermal	890:896	arg1	properties					898:907	thermal properties	890:907	thermal properties	890:907	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	1	35	theme	polyelectrolyte	227:241	arg1	solutions					243:251	oppositely charged polyelectrolyte solutions	208:251	oppositely charged polyelectrolyte solutions	208:251	Polyelectrolyte complexes (PECs) are spontaneously formed by mixing oppositely charged polyelectrolyte solutions without the use of organic solvents and chemical crosslinkers are great candidate carriers for drug delivery.
33385446	5	36	dep	in	988:989	arg1	vitro					991:995	vitro	991:995	vitro	991:995	The stoichiometric PECs of DPCS showed good in vitro biocompatibility, pH sensitivity and biodegradability depending on the hydrogel composition.
33385446	3	37	from	acid	689:692	arg1	melt					704:707	a urea melt	697:707	a urea melt under reduced pressure	697:730	For this purpose, the simultaneous partial crosslinking and functionalization of dextran with phosphoric acid in a urea melt under reduced pressure were studied.
33385446	8	38	theme	efficacy	1505:1512	arg1	hydrogels					1526:1534	the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels	1464:1534	the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels	1464:1534	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	8	39	theme	degradation	1372:1382	arg1	behavior					1384:1391	The tunable degradation behavior	1360:1391	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels	1360:1534	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	8	40	theme	pristine	1468:1475	arg1	DPCS					1477:1480	the pristine DPCS	1464:1480	the pristine DPCS	1464:1480	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	3	41	theme	phosphoric	678:687	arg1	acid					689:692	phosphoric acid	678:692	phosphoric acid in a urea melt under reduced pressure	678:730	For this purpose, the simultaneous partial crosslinking and functionalization of dextran with phosphoric acid in a urea melt under reduced pressure were studied.
33385446	2	42	theme	dextran	439:445	arg1	phosphate					447:455	dextran phosphate	439:455	dextran phosphate	439:455	Herein, biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin were developed and characterized in order to assess their suitability for biomedical applications.
33385446	7	43	theme	antimicrobial	1257:1269	arg1	activity					1271:1278	antimicrobial activity	1257:1278	antimicrobial activity against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus	1257:1357	The drug-loaded hydrogels showed antimicrobial activity against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus.
33385446	0	44	theme	chitosan	43:50	arg1	complexes					30:38	Biodegradable polyelectrolyte complexes	0:38	Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications	0:137	Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications.
33385446	1	45	theme	drug	348:351	arg1	delivery					353:360	drug delivery	348:360	drug delivery	348:360	Polyelectrolyte complexes (PECs) are spontaneously formed by mixing oppositely charged polyelectrolyte solutions without the use of organic solvents and chemical crosslinkers are great candidate carriers for drug delivery.
33385446	5	46	theme	stoichiometric	948:961	arg1	PECs					963:966	The stoichiometric PECs	944:966	The stoichiometric PECs of DPCS	944:974	The stoichiometric PECs of DPCS showed good in vitro biocompatibility, pH sensitivity and biodegradability depending on the hydrogel composition.
33385446	6	47	theme	drug	1105:1108	arg1	release					1094:1100	The release	1090:1100	The release of drug from cefazolin-loaded DPCS hydrogels	1090:1145	The release of drug from cefazolin-loaded DPCS hydrogels was through non-Fickian diffusion and displayed long sustained-release time.
33385446	6	48	theme	DPCS	1132:1135	arg1	hydrogels					1137:1145	cefazolin-loaded DPCS hydrogels	1115:1145	cefazolin-loaded DPCS hydrogels	1115:1145	The release of drug from cefazolin-loaded DPCS hydrogels was through non-Fickian diffusion and displayed long sustained-release time.
33385446	0	49	theme	crosslinked	66:76	arg1	phosphate					86:94	partially crosslinked dextran phosphate	56:94	partially crosslinked dextran phosphate	56:94	Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications.
33385446	8	50	theme	tunable	1364:1370	arg1	behavior					1384:1391	The tunable degradation behavior	1360:1391	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels	1360:1534	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	2	51	theme	biomedical	559:568	arg1	applications					570:581	biomedical applications	559:581	biomedical applications	559:581	Herein, biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin were developed and characterized in order to assess their suitability for biomedical applications.
33385446	3	52	theme	dextran	665:671	arg1	functionalization					644:660	functionalization	644:660	functionalization	644:660	For this purpose, the simultaneous partial crosslinking and functionalization of dextran with phosphoric acid in a urea melt under reduced pressure were studied.
33385446	3	52	theme	dextran	665:671	arg1	crosslinking					627:638	simultaneous partial crosslinking	606:638	simultaneous partial crosslinking	606:638	For this purpose, the simultaneous partial crosslinking and functionalization of dextran with phosphoric acid in a urea melt under reduced pressure were studied.
33385446	0	53	with	complexes	30:38	arg1	potential					101:109	potential	101:109	potential for biomedical applications	101:137	Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications.
33385446	1	54	theme	Polyelectrolyte	140:154	arg1	PECs					167:170	PECs	167:170	PECs	167:170	Polyelectrolyte complexes (PECs) are spontaneously formed by mixing oppositely charged polyelectrolyte solutions without the use of organic solvents and chemical crosslinkers are great candidate carriers for drug delivery.
33385446	1	54	theme	Polyelectrolyte	140:154	arg1	complexes					156:164	Polyelectrolyte complexes	140:164	Polyelectrolyte complexes (PECs)	140:171	Polyelectrolyte complexes (PECs) are spontaneously formed by mixing oppositely charged polyelectrolyte solutions without the use of organic solvents and chemical crosslinkers are great candidate carriers for drug delivery.
33385446	6	55	theme	non-Fickian	1159:1169	arg1	diffusion					1171:1179	non-Fickian diffusion	1159:1179	non-Fickian diffusion	1159:1179	The release of drug from cefazolin-loaded DPCS hydrogels was through non-Fickian diffusion and displayed long sustained-release time.
33385446	2	56	theme	antimicrobial	385:397	arg1	complexes					415:423	biodegradable antimicrobial polyelectrolyte complexes	371:423	biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin	371:483	Herein, biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin were developed and characterized in order to assess their suitability for biomedical applications.
33385446	8	57	from	behavior	1384:1391	arg1	combination					1427:1437	combination	1427:1437	combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels	1427:1534	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	2	58	contain	containing	464:473	arg2	cefazolin					475:483	cefazolin	475:483	cefazolin	475:483	Herein, biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin were developed and characterized in order to assess their suitability for biomedical applications.
33385446	2	58	contain	containing	464:473	arg1	complexes					415:423	biodegradable antimicrobial polyelectrolyte complexes	371:423	biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin	371:483	Herein, biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin were developed and characterized in order to assess their suitability for biomedical applications.
33385446	3	59	theme	urea	699:702	arg1	melt					704:707	a urea melt	697:707	a urea melt under reduced pressure	697:730	For this purpose, the simultaneous partial crosslinking and functionalization of dextran with phosphoric acid in a urea melt under reduced pressure were studied.
33385446	2	60	theme	biodegradable	371:383	arg1	complexes					415:423	biodegradable antimicrobial polyelectrolyte complexes	371:423	biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin	371:483	Herein, biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin were developed and characterized in order to assess their suitability for biomedical applications.
33385446	6	61	theme	cefazolin-loaded	1115:1130	arg1	hydrogels					1137:1145	cefazolin-loaded DPCS hydrogels	1115:1145	cefazolin-loaded DPCS hydrogels	1115:1145	The release of drug from cefazolin-loaded DPCS hydrogels was through non-Fickian diffusion and displayed long sustained-release time.
33385446	5	62	theme	in	988:989	arg1	biocompatibility					997:1012	good in vitro biocompatibility	983:1012	good in vitro biocompatibility	983:1012	The stoichiometric PECs of DPCS showed good in vitro biocompatibility, pH sensitivity and biodegradability depending on the hydrogel composition.
33385446	4	63	theme	phosphate	807:815	arg1	content					767:773	functional group content	750:773	functional group content	750:773	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	4	63	theme	phosphate	807:815	arg1	weight					789:794	molecular weight	779:794	molecular weight	779:794	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	4	64	theme	group	761:765	arg1	content					767:773	functional group content	750:773	functional group content	750:773	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	6	65	from	hydrogels	1137:1145	arg1	release					1094:1100	The release	1090:1100	The release of drug from cefazolin-loaded DPCS hydrogels	1090:1145	The release of drug from cefazolin-loaded DPCS hydrogels was through non-Fickian diffusion and displayed long sustained-release time.
33385446	4	66	theme	gel	870:872	arg1	morphologies					913:924	morphologies	913:924	morphologies	913:924	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	4	66	theme	gel	870:872	arg1	yield					883:887	gel fraction yield	870:887	gel fraction yield	870:887	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	4	66	theme	gel	870:872	arg1	properties					898:907	thermal properties	890:907	thermal properties	890:907	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	0	67	theme	phosphate	86:94	arg1	complexes					30:38	Biodegradable polyelectrolyte complexes	0:38	Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications	0:137	Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications.
33385446	5	68	theme	DPCS	971:974	arg1	PECs					963:966	The stoichiometric PECs	944:966	The stoichiometric PECs of DPCS	944:974	The stoichiometric PECs of DPCS showed good in vitro biocompatibility, pH sensitivity and biodegradability depending on the hydrogel composition.
33385446	3	69	dep	crosslinking	627:638	arg1	the					602:604	the	602:604	the	602:604	For this purpose, the simultaneous partial crosslinking and functionalization of dextran with phosphoric acid in a urea melt under reduced pressure were studied.
33385446	8	70	theme	high	1486:1489	arg1	efficacy					1505:1512	high antibacterial efficacy	1486:1512	high antibacterial efficacy	1486:1512	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	1	71	theme	organic	272:278	arg1	solvents					280:287	organic solvents	272:287	organic solvents	272:287	Polyelectrolyte complexes (PECs) are spontaneously formed by mixing oppositely charged polyelectrolyte solutions without the use of organic solvents and chemical crosslinkers are great candidate carriers for drug delivery.
33385446	0	72	theme	dextran	78:84	arg1	phosphate					86:94	partially crosslinked dextran phosphate	56:94	partially crosslinked dextran phosphate	56:94	Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications.
33385446	8	73	with	combination	1427:1437	arg1	biocompatibility					1444:1459	biocompatibility	1444:1459	biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels	1444:1534	The tunable degradation behavior under physiological conditions in combination with biocompatibility of the pristine DPCS and high antibacterial efficacy drug-loaded hydrogels may render the presented materials interesting for biomedical applications.
33385446	4	74	theme	fraction	874:881	arg1	morphologies					913:924	morphologies	913:924	morphologies	913:924	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	4	74	theme	fraction	874:881	arg1	yield					883:887	gel fraction yield	870:887	gel fraction yield	870:887	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	4	74	theme	fraction	874:881	arg1	properties					898:907	thermal properties	890:907	thermal properties	890:907	The functional group content and molecular weight of dextran phosphate were varied in order to establish their influence on gel fraction yield, thermal properties and morphologies of the hydrogels.
33385446	2	75	theme	chitosan	428:435	arg1	complexes					415:423	biodegradable antimicrobial polyelectrolyte complexes	371:423	biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin	371:483	Herein, biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin were developed and characterized in order to assess their suitability for biomedical applications.
33385446	1	76	theme	solvents	280:287	arg1	use					265:267	the use	261:267	the use of organic solvents	261:287	Polyelectrolyte complexes (PECs) are spontaneously formed by mixing oppositely charged polyelectrolyte solutions without the use of organic solvents and chemical crosslinkers are great candidate carriers for drug delivery.
34973753	0	0	theme	durable	87:93	arg1	fabrics					120:126	durable and antimicrobial cotton fabrics	87:126	durable and antimicrobial cotton fabrics	87:126	Preparation of quaternized chitosan/Ag composite nanogels in inverse miniemulsions for durable and antimicrobial cotton fabrics.
34973753	6	1	theme	urgent	1104:1109	arg1	need					1111:1114	the urgent need	1100:1114	the urgent need for antibacterial agents/fabrics	1100:1147	Our study provides a facile and controllable method to construct polymer/inorganic CNGs to address the urgent need for antibacterial agents/fabrics.
34973753	2	2	theme	miniemulsion	372:383	arg1	technique					385:393	inverse miniemulsion technique	364:393	inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs)	364:460	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	6	3	theme	controllable	1033:1044	arg1	method					1046:1051	a facile and controllable method	1020:1051	a facile and controllable method to construct polymer/inorganic CNGs to address the urgent need for antibacterial agents/fabrics	1020:1147	Our study provides a facile and controllable method to construct polymer/inorganic CNGs to address the urgent need for antibacterial agents/fabrics.
34973753	0	4	theme	cotton	113:118	arg1	fabrics					120:126	durable and antimicrobial cotton fabrics	87:126	durable and antimicrobial cotton fabrics	87:126	Preparation of quaternized chitosan/Ag composite nanogels in inverse miniemulsions for durable and antimicrobial cotton fabrics.
34973753	3	5	theme	Ag	588:589	arg1	NPs					591:593	Ag NPs	588:593	Ag NPs	588:593	The QCS/Ag CNGs possess superior broad-spectrum antimicrobial activity and low biotoxicity, via synergistic sterilization of Ag NPs and QCS.
34973753	3	6	theme	QCS	599:601	arg1	sterilization					571:583	synergistic sterilization	559:583	synergistic sterilization of Ag NPs and QCS	559:601	The QCS/Ag CNGs possess superior broad-spectrum antimicrobial activity and low biotoxicity, via synergistic sterilization of Ag NPs and QCS.
34973753	0	7	theme	antimicrobial	99:111	arg1	fabrics					120:126	durable and antimicrobial cotton fabrics	87:126	durable and antimicrobial cotton fabrics	87:126	Preparation of quaternized chitosan/Ag composite nanogels in inverse miniemulsions for durable and antimicrobial cotton fabrics.
34973753	3	8	theme	NPs	591:593	arg1	sterilization					571:583	synergistic sterilization	559:583	synergistic sterilization of Ag NPs and QCS	559:601	The QCS/Ag CNGs possess superior broad-spectrum antimicrobial activity and low biotoxicity, via synergistic sterilization of Ag NPs and QCS.
34973753	2	9	theme	QCS/Ag	303:308	arg1	nanogels					293:300	antimicrobial quaternized chitosan/Ag composite nanogels	245:300	antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties	245:338	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	2	9	theme	QCS/Ag	303:308	arg1	CNGs					310:313	QCS/Ag CNGs	303:313	QCS/Ag CNGs	303:313	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	4	10	theme	NH2-Ag	621:626	arg1	NPs					628:630	the NH2-Ag NPs	617:630	the NH2-Ag NPs	617:630	Furthermore, the NH2-Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics.
34973753	4	11	theme	QCS/Ag	712:717	arg1	CNGs					719:722	the QCS/Ag CNGs	708:722	the QCS/Ag CNGs	708:722	Furthermore, the NH2-Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics.
34973753	4	12	theme	reactive	729:736	arg1	groups					738:743	reactive groups	729:743	reactive groups	729:743	Furthermore, the NH2-Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics.
34973753	5	13	theme	antimicrobial	890:902	arg1	effect					904:909	antimicrobial effect	890:909	antimicrobial effect	890:909	Thus, QCS/Ag CNGs modified cotton fabrics exhibited laundering durability of antimicrobial effect after 100 washing cycles without sacrificing other inherent properties of cotton fabrics.
34973753	4	14	theme	cotton	797:802	arg1	fabrics					804:810	durable antibacterial cotton fabrics	775:810	durable antibacterial cotton fabrics	775:810	Furthermore, the NH2-Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics.
34973753	5	15	theme	effect	904:909	arg1	durability					876:885	laundering durability	865:885	laundering durability of antimicrobial effect	865:909	Thus, QCS/Ag CNGs modified cotton fabrics exhibited laundering durability of antimicrobial effect after 100 washing cycles without sacrificing other inherent properties of cotton fabrics.
34973753	1	16	theme	antimicrobial	171:183	arg1	agents					185:190	effective antimicrobial agents	161:190	effective antimicrobial agents	161:190	It is an urgent task to exploit effective antimicrobial agents due to the rise of drug-resistant pathogens.
34973753	6	17	theme	facile	1022:1027	arg1	method					1046:1051	a facile and controllable method	1020:1051	a facile and controllable method to construct polymer/inorganic CNGs to address the urgent need for antibacterial agents/fabrics	1020:1147	Our study provides a facile and controllable method to construct polymer/inorganic CNGs to address the urgent need for antibacterial agents/fabrics.
34973753	4	18	contain	have	724:727	arg2	groups					738:743	reactive groups	729:743	reactive groups	729:743	Furthermore, the NH2-Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics.
34973753	4	18	contain	have	724:727	arg1	CNGs					719:722	the QCS/Ag CNGs	708:722	the QCS/Ag CNGs	708:722	Furthermore, the NH2-Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics.
34973753	4	19	theme	antibacterial	783:795	arg1	fabrics					804:810	durable antibacterial cotton fabrics	775:810	durable antibacterial cotton fabrics	775:810	Furthermore, the NH2-Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics.
34973753	3	20	theme	QCS/Ag	467:472	arg1	CNGs					474:477	The QCS/Ag CNGs	463:477	The QCS/Ag CNGs	463:477	The QCS/Ag CNGs possess superior broad-spectrum antimicrobial activity and low biotoxicity, via synergistic sterilization of Ag NPs and QCS.
34973753	5	21	theme	QCS/Ag	819:824	arg1	fabrics					847:853	QCS/Ag CNGs modified cotton fabrics	819:853	QCS/Ag CNGs modified cotton fabrics	819:853	Thus, QCS/Ag CNGs modified cotton fabrics exhibited laundering durability of antimicrobial effect after 100 washing cycles without sacrificing other inherent properties of cotton fabrics.
34973753	2	22	theme	encapsulation	407:419	arg1	efficiency					421:430	a high encapsulation efficiency	400:430	a high encapsulation efficiency of NH2-Ag nanoparticles (NPs)	400:460	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	5	23	theme	CNGs	826:829	arg1	fabrics					847:853	QCS/Ag CNGs modified cotton fabrics	819:853	QCS/Ag CNGs modified cotton fabrics	819:853	Thus, QCS/Ag CNGs modified cotton fabrics exhibited laundering durability of antimicrobial effect after 100 washing cycles without sacrificing other inherent properties of cotton fabrics.
34973753	4	24	theme	base	688:691	arg1	reactions					693:701	Schiff base reactions	681:701	Schiff base reactions	681:701	Furthermore, the NH2-Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics.
34973753	2	25	theme	tunable	321:327	arg1	properties					329:338	tunable properties	321:338	tunable properties	321:338	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	4	26	theme	durable	775:781	arg1	fabrics					804:810	durable antibacterial cotton fabrics	775:810	durable antibacterial cotton fabrics	775:810	Furthermore, the NH2-Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics.
34973753	2	27	theme	high	402:405	arg1	efficiency					421:430	a high encapsulation efficiency	400:430	a high encapsulation efficiency of NH2-Ag nanoparticles (NPs)	400:460	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	0	28	theme	chitosan/Ag	27:37	arg1	composite					39:47	quaternized chitosan/Ag composite	15:47	quaternized chitosan/Ag composite	15:47	Preparation of quaternized chitosan/Ag composite nanogels in inverse miniemulsions for durable and antimicrobial cotton fabrics.
34973753	6	29	theme	antibacterial	1120:1132	arg1	agents/fabrics					1134:1147	antibacterial agents/fabrics	1120:1147	antibacterial agents/fabrics	1120:1147	Our study provides a facile and controllable method to construct polymer/inorganic CNGs to address the urgent need for antibacterial agents/fabrics.
34973753	5	30	theme	fabrics	992:998	arg1	properties					971:980	other inherent properties	956:980	other inherent properties of cotton fabrics	956:998	Thus, QCS/Ag CNGs modified cotton fabrics exhibited laundering durability of antimicrobial effect after 100 washing cycles without sacrificing other inherent properties of cotton fabrics.
34973753	3	31	theme	superior	487:494	arg1	activity					525:532	superior broad-spectrum antimicrobial activity	487:532	superior broad-spectrum antimicrobial activity	487:532	The QCS/Ag CNGs possess superior broad-spectrum antimicrobial activity and low biotoxicity, via synergistic sterilization of Ag NPs and QCS.
34973753	0	32	theme	quaternized	15:25	arg1	composite					39:47	quaternized chitosan/Ag composite	15:47	quaternized chitosan/Ag composite	15:47	Preparation of quaternized chitosan/Ag composite nanogels in inverse miniemulsions for durable and antimicrobial cotton fabrics.
34973753	5	33	theme	cotton	985:990	arg1	fabrics					992:998	cotton fabrics	985:998	cotton fabrics	985:998	Thus, QCS/Ag CNGs modified cotton fabrics exhibited laundering durability of antimicrobial effect after 100 washing cycles without sacrificing other inherent properties of cotton fabrics.
34973753	3	34	contain	possess	479:485	arg2	activity					525:532	superior broad-spectrum antimicrobial activity	487:532	superior broad-spectrum antimicrobial activity	487:532	The QCS/Ag CNGs possess superior broad-spectrum antimicrobial activity and low biotoxicity, via synergistic sterilization of Ag NPs and QCS.
34973753	3	34	contain	possess	479:485	arg1	CNGs					474:477	The QCS/Ag CNGs	463:477	The QCS/Ag CNGs	463:477	The QCS/Ag CNGs possess superior broad-spectrum antimicrobial activity and low biotoxicity, via synergistic sterilization of Ag NPs and QCS.
34973753	3	34	contain	possess	479:485	arg2	biotoxicity					542:552	low biotoxicity	538:552	low biotoxicity	538:552	The QCS/Ag CNGs possess superior broad-spectrum antimicrobial activity and low biotoxicity, via synergistic sterilization of Ag NPs and QCS.
34973753	1	35	theme	effective	161:169	arg1	agents					185:190	effective antimicrobial agents	161:190	effective antimicrobial agents	161:190	It is an urgent task to exploit effective antimicrobial agents due to the rise of drug-resistant pathogens.
34973753	3	36	theme	broad-spectrum	496:509	arg1	activity					525:532	superior broad-spectrum antimicrobial activity	487:532	superior broad-spectrum antimicrobial activity	487:532	The QCS/Ag CNGs possess superior broad-spectrum antimicrobial activity and low biotoxicity, via synergistic sterilization of Ag NPs and QCS.
34973753	5	37	theme	other	956:960	arg1	properties					971:980	other inherent properties	956:980	other inherent properties of cotton fabrics	956:998	Thus, QCS/Ag CNGs modified cotton fabrics exhibited laundering durability of antimicrobial effect after 100 washing cycles without sacrificing other inherent properties of cotton fabrics.
34973753	5	38	theme	laundering	865:874	arg1	durability					876:885	laundering durability	865:885	laundering durability of antimicrobial effect	865:909	Thus, QCS/Ag CNGs modified cotton fabrics exhibited laundering durability of antimicrobial effect after 100 washing cycles without sacrificing other inherent properties of cotton fabrics.
34973753	2	39	theme	nanoparticles	442:454	arg1	efficiency					421:430	a high encapsulation efficiency	400:430	a high encapsulation efficiency of NH2-Ag nanoparticles (NPs)	400:460	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	0	40	theme	composite	39:47	arg1	Preparation					0:10	Preparation	0:10	Preparation of quaternized chitosan/Ag composite	0:47	Preparation of quaternized chitosan/Ag composite nanogels in inverse miniemulsions for durable and antimicrobial cotton fabrics.
34973753	5	41	theme	modified	831:838	arg1	fabrics					847:853	QCS/Ag CNGs modified cotton fabrics	819:853	QCS/Ag CNGs modified cotton fabrics	819:853	Thus, QCS/Ag CNGs modified cotton fabrics exhibited laundering durability of antimicrobial effect after 100 washing cycles without sacrificing other inherent properties of cotton fabrics.
34973753	1	42	theme	drug-resistant	211:224	arg1	pathogens					226:234	drug-resistant pathogens	211:234	drug-resistant pathogens	211:234	It is an urgent task to exploit effective antimicrobial agents due to the rise of drug-resistant pathogens.
34973753	0	43	theme	inverse	61:67	arg1	miniemulsions					69:81	inverse miniemulsions	61:81	inverse miniemulsions for durable and antimicrobial cotton fabrics	61:126	Preparation of quaternized chitosan/Ag composite nanogels in inverse miniemulsions for durable and antimicrobial cotton fabrics.
34973753	5	44	theme	cotton	840:845	arg1	fabrics					847:853	QCS/Ag CNGs modified cotton fabrics	819:853	QCS/Ag CNGs modified cotton fabrics	819:853	Thus, QCS/Ag CNGs modified cotton fabrics exhibited laundering durability of antimicrobial effect after 100 washing cycles without sacrificing other inherent properties of cotton fabrics.
34973753	4	45	attach	linked	648:653	arg1	matrix					666:671	the QCS matrix	658:671	the QCS matrix	658:671	Furthermore, the NH2-Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics.
34973753	4	45	attach	linked	648:653	arg2	NPs					628:630	the NH2-Ag NPs	617:630	the NH2-Ag NPs	617:630	Furthermore, the NH2-Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics.
34973753	2	46	theme	inverse	364:370	arg1	technique					385:393	inverse miniemulsion technique	364:393	inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs)	364:460	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	2	47	with	technique	385:393	arg1	efficiency					421:430	a high encapsulation efficiency	400:430	a high encapsulation efficiency of NH2-Ag nanoparticles (NPs)	400:460	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	3	48	theme	low	538:540	arg1	biotoxicity					542:552	low biotoxicity	538:552	low biotoxicity	538:552	The QCS/Ag CNGs possess superior broad-spectrum antimicrobial activity and low biotoxicity, via synergistic sterilization of Ag NPs and QCS.
34973753	2	49	theme	composite	283:291	arg1	nanogels					293:300	antimicrobial quaternized chitosan/Ag composite nanogels	245:300	antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties	245:338	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	2	49	theme	composite	283:291	arg1	CNGs					310:313	QCS/Ag CNGs	303:313	QCS/Ag CNGs	303:313	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	6	50	theme	polymer/inorganic	1066:1082	arg1	CNGs					1084:1087	polymer/inorganic CNGs	1066:1087	polymer/inorganic CNGs	1066:1087	Our study provides a facile and controllable method to construct polymer/inorganic CNGs to address the urgent need for antibacterial agents/fabrics.
34973753	3	51	theme	antimicrobial	511:523	arg1	activity					525:532	superior broad-spectrum antimicrobial activity	487:532	superior broad-spectrum antimicrobial activity	487:532	The QCS/Ag CNGs possess superior broad-spectrum antimicrobial activity and low biotoxicity, via synergistic sterilization of Ag NPs and QCS.
34973753	1	52	theme	pathogens	226:234	arg1	rise					203:206	the rise	199:206	the rise of drug-resistant pathogens	199:234	It is an urgent task to exploit effective antimicrobial agents due to the rise of drug-resistant pathogens.
34973753	5	53	theme	inherent	962:969	arg1	properties					971:980	other inherent properties	956:980	other inherent properties of cotton fabrics	956:998	Thus, QCS/Ag CNGs modified cotton fabrics exhibited laundering durability of antimicrobial effect after 100 washing cycles without sacrificing other inherent properties of cotton fabrics.
34973753	2	54	theme	chitosan/Ag	271:281	arg1	nanogels					293:300	antimicrobial quaternized chitosan/Ag composite nanogels	245:300	antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties	245:338	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	2	54	theme	chitosan/Ag	271:281	arg1	CNGs					310:313	QCS/Ag CNGs	303:313	QCS/Ag CNGs	303:313	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	1	55	theme	urgent	138:143	arg1	It					129:130	It	129:130	It	129:130	It is an urgent task to exploit effective antimicrobial agents due to the rise of drug-resistant pathogens.
34973753	1	55	theme	urgent	138:143	arg1	task					145:148	an urgent task	135:148	an urgent task to exploit effective antimicrobial agents due to the rise of drug-resistant pathogens	135:234	It is an urgent task to exploit effective antimicrobial agents due to the rise of drug-resistant pathogens.
34973753	2	56	with	nanogels	293:300	arg1	properties					329:338	tunable properties	321:338	tunable properties	321:338	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	2	57	theme	NH2-Ag	435:440	arg1	nanoparticles					442:454	NH2-Ag nanoparticles	435:454	NH2-Ag nanoparticles (NPs)	435:460	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	2	57	theme	NH2-Ag	435:440	arg1	NPs					457:459	NPs	457:459	NPs	457:459	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	2	58	theme	quaternized	259:269	arg1	nanogels					293:300	antimicrobial quaternized chitosan/Ag composite nanogels	245:300	antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties	245:338	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	2	58	theme	quaternized	259:269	arg1	CNGs					310:313	QCS/Ag CNGs	303:313	QCS/Ag CNGs	303:313	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	4	59	theme	QCS	662:664	arg1	matrix					666:671	the QCS matrix	658:671	the QCS matrix	658:671	Furthermore, the NH2-Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics.
34973753	5	60	theme	washing	921:927	arg1	cycles					929:934	100 washing cycles	917:934	100 washing cycles	917:934	Thus, QCS/Ag CNGs modified cotton fabrics exhibited laundering durability of antimicrobial effect after 100 washing cycles without sacrificing other inherent properties of cotton fabrics.
34973753	4	61	theme	Schiff	681:686	arg1	reactions					693:701	Schiff base reactions	681:701	Schiff base reactions	681:701	Furthermore, the NH2-Ag NPs were chemically linked to the QCS matrix through Schiff base reactions, and the QCS/Ag CNGs have reactive groups, making it possible to obtain durable antibacterial cotton fabrics.
34973753	2	62	theme	antimicrobial	245:257	arg1	nanogels					293:300	antimicrobial quaternized chitosan/Ag composite nanogels	245:300	antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties	245:338	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	2	62	theme	antimicrobial	245:257	arg1	CNGs					310:313	QCS/Ag CNGs	303:313	QCS/Ag CNGs	303:313	Herein, antimicrobial quaternized chitosan/Ag composite nanogels (QCS/Ag CNGs) with tunable properties were fabricated through inverse miniemulsion technique with a high encapsulation efficiency of NH2-Ag nanoparticles (NPs).
34973753	3	63	theme	synergistic	559:569	arg1	sterilization					571:583	synergistic sterilization	559:583	synergistic sterilization of Ag NPs and QCS	559:601	The QCS/Ag CNGs possess superior broad-spectrum antimicrobial activity and low biotoxicity, via synergistic sterilization of Ag NPs and QCS.
34146415	2	0	theme	molecular	522:530	arg1	Mw					540:541	Mw	540:541	Mw	540:541	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	0	theme	molecular	522:530	arg1	weight					532:537	the molecular weight	518:537	the molecular weight (Mw ) distributions	518:557	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	1	from	Changes	281:287	arg1	characteristics					292:306	characteristics	292:306	characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	292:638	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	6	2	theme	crucial	1013:1019	arg1	compositions					1021:1032	the crucial compositions	1009:1032	the crucial compositions in three pectins	1009:1049	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	6	2	theme	crucial	1013:1019	arg1	glucose					990:996	glucose	990:996	glucose (Glc)	990:1002	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	6	2	theme	crucial	1013:1019	arg1	arabinose					970:978	arabinose	970:978	arabinose (Ara)	970:984	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	6	2	theme	crucial	1013:1019	arg1	Rhamnose					954:961	Rhamnose	954:961	Rhamnose (Rha)	954:967	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	16	3	theme	jujube	2621:2626	arg1	softening					2628:2636	jujube softening	2621:2636	jujube softening	2621:2636	This study would elucidate the mechanism of jujube softening and help to regulate the postharvest quality during cold storage.
34146415	11	4	theme	jujube	1786:1791	arg1	fruits					1793:1798	jujube fruits	1786:1798	jujube fruits	1786:1798	WSP and SSP were more contributed to the softening of jujubes compared to CSP, and they played the critical role for regulating the softening of jujube fruits during cold storage.
34146415	7	5	theme	rhamnogalacturonan-I	1261:1280	arg1	chains					1251:1256	the branch chains	1240:1256	the branch chains of rhamnogalacturonan-I in three pectins	1240:1297	Changes in the ratio of (galactose (Gal)+Ara)/Rha and Ara/Gal represented that the branch chains of rhamnogalacturonan-I in three pectins depolymerized after storage.
34146415	2	6	from	characteristics	292:306	arg1	JS					636:637	JS	636:637	JS	636:637	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	6	from	characteristics	292:306	arg1	Dongzao					605:611	Dongzao	605:611	Dongzao	605:611	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	6	from	characteristics	292:306	arg1	fruits					595:600	two jujube fruits	584:600	two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	584:638	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	7	7	theme	Ara/Gal	1215:1221	arg1	ratio					1176:1180	the ratio	1172:1180	the ratio of (galactose (Gal)+Ara)/Rha and Ara/Gal	1172:1221	Changes in the ratio of (galactose (Gal)+Ara)/Rha and Ara/Gal represented that the branch chains of rhamnogalacturonan-I in three pectins depolymerized after storage.
34146415	1	8	theme	factors	133:139	arg1	one					117:119	one	117:119	one	117:119	Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	1	8	theme	factors	133:139	arg1	factors					133:139	the main factors	124:139	the main factors affecting market value and consumer preferences for jujubes	124:199	Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	7	9	theme	/Rha	1206:1209	arg1	ratio					1176:1180	the ratio	1172:1180	the ratio of (galactose (Gal)+Ara)/Rha and Ara/Gal	1172:1221	Changes in the ratio of (galactose (Gal)+Ara)/Rha and Ara/Gal represented that the branch chains of rhamnogalacturonan-I in three pectins depolymerized after storage.
34146415	12	10	theme	consumer	1908:1915	arg1	preferences					1917:1927	consumer preferences	1908:1927	consumer preferences	1908:1927	PRACTICAL APPLICATION: Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	6	11	theme	sugar	1069:1073	arg1	compositions					1075:1086	most neutral sugar compositions	1056:1086	most neutral sugar compositions	1056:1086	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	1	12	theme	market	151:156	arg1	value					158:162	market value	151:162	market value	151:162	Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	4	13	theme	firmness	803:810	arg1	reduction					790:798	The reduction	786:798	The reduction of firmness	786:810	The reduction of firmness corresponded to a conversion of water-insoluble pectin to WSP during cold storage.
34146415	15	14	theme	cold	2563:2566	arg1	storage					2568:2574	cold storage	2563:2574	cold storage	2563:2574	WSP and SSP were more contributed to the softening of jujubes compared to CSP, and they played the critical role for regulating the softening of jujube fruits during cold storage.
34146415	12	15	theme	main	1868:1871	arg1	factors					1873:1879	the main factors	1864:1879	the main factors affecting market value and consumer preferences for jujubes	1864:1939	PRACTICAL APPLICATION: Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	0	16	theme	cold	90:93	arg1	storage					95:101	cold storage	90:101	cold storage	90:101	Changes in pectin characteristics of jujube fruits cv "Dongzao" and "Jinsixiaozao" during cold storage.
34146415	5	17	theme	late	940:943	arg1	storage					945:951	the late storage	936:951	the late storage	936:951	DM of WSP presented an increase trend in the late storage.
34146415	9	18	from	increase	1475:1482	arg1	chains					1493:1498	short chains	1487:1498	short chains	1487:1498	AFM images showed an increase in short chains and branch structures of three pectins after storage.
34146415	9	19	theme	branch	1504:1509	arg1	structures					1511:1520	branch structures	1504:1520	branch structures of three pectins	1504:1537	AFM images showed an increase in short chains and branch structures of three pectins after storage.
34146415	6	20	theme	neutral	1061:1067	arg1	compositions					1075:1086	most neutral sugar compositions	1056:1086	most neutral sugar compositions	1056:1086	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	15	21	theme	jujube	2542:2547	arg1	fruits					2549:2554	jujube fruits	2542:2554	jujube fruits	2542:2554	WSP and SSP were more contributed to the softening of jujubes compared to CSP, and they played the critical role for regulating the softening of jujube fruits during cold storage.
34146415	2	22	theme	sugar	498:502	arg1	compositions					504:515	neutral sugar compositions	490:515	neutral sugar compositions	490:515	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	7	23	theme	galactose	1186:1194	arg1	/Rha					1206:1209	/Rha	1206:1209	/Rha	1206:1209	Changes in the ratio of (galactose (Gal)+Ara)/Rha and Ara/Gal represented that the branch chains of rhamnogalacturonan-I in three pectins depolymerized after storage.
34146415	7	23	theme	galactose	1186:1194	arg1	+Ara					1201:1204	galactose (Gal)+Ara	1186:1204	galactose (Gal)+Ara	1186:1204	Changes in the ratio of (galactose (Gal)+Ara)/Rha and Ara/Gal represented that the branch chains of rhamnogalacturonan-I in three pectins depolymerized after storage.
34146415	5	24	theme	increase	918:925	arg1	trend					927:931	an increase trend	915:931	an increase trend	915:931	DM of WSP presented an increase trend in the late storage.
34146415	9	25	theme	pectins	1531:1537	arg1	increase					1475:1482	an increase	1472:1482	an increase in short chains	1472:1498	AFM images showed an increase in short chains and branch structures of three pectins after storage.
34146415	9	25	theme	pectins	1531:1537	arg1	structures					1511:1520	branch structures	1504:1520	branch structures of three pectins	1504:1537	AFM images showed an increase in short chains and branch structures of three pectins after storage.
34146415	2	26	theme	weight	532:537	arg1	distributions					545:557	the molecular weight (Mw ) distributions	518:557	the molecular weight (Mw ) distributions	518:557	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	10	27	theme	cold	1627:1630	arg1	storage					1632:1638	cold storage	1627:1638	cold storage	1627:1638	Overall, three pectins in DZ and JS depolymerized and solubilized during cold storage.
34146415	2	28	dep	fruits	595:600	arg1	JS					636:637	JS	636:637	JS	636:637	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	28	dep	fruits	595:600	arg1	DZ					614:615	DZ	614:615	DZ	614:615	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	28	dep	fruits	595:600	arg1	Dongzao					605:611	Dongzao	605:611	Dongzao	605:611	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	28	dep	fruits	595:600	arg1	fruits					595:600	two jujube fruits	584:600	two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	584:638	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	12	29	theme	PRACTICAL	1821:1829	arg1	APPLICATION					1831:1841	PRACTICAL APPLICATION	1821:1841	PRACTICAL APPLICATION: Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.	1821:2019	PRACTICAL APPLICATION: Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	15	30	theme	jujubes	2451:2457	arg1	softening					2438:2446	the softening	2434:2446	the softening of jujubes	2434:2457	WSP and SSP were more contributed to the softening of jujubes compared to CSP, and they played the critical role for regulating the softening of jujube fruits during cold storage.
34146415	10	31	from	pectins	1569:1575	arg1	JS					1587:1588	JS	1587:1588	JS	1587:1588	Overall, three pectins in DZ and JS depolymerized and solubilized during cold storage.
34146415	10	31	from	pectins	1569:1575	arg1	DZ					1580:1581	DZ	1580:1581	DZ	1580:1581	Overall, three pectins in DZ and JS depolymerized and solubilized during cold storage.
34146415	5	32	attach	presented	905:913	arg1	storage					945:951	the late storage	936:951	the late storage	936:951	DM of WSP presented an increase trend in the late storage.
34146415	5	32	attach	presented	905:913	arg2	DM					895:896	DM	895:896	DM of WSP	895:903	DM of WSP presented an increase trend in the late storage.
34146415	2	33	from	fruits	595:600	arg1	distributions					545:557	the molecular weight (Mw ) distributions	518:557	the molecular weight (Mw ) distributions	518:557	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	33	from	fruits	595:600	arg1	degree					453:458	degree	453:458	degree of methylesterification (DM)	453:487	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	33	from	fruits	595:600	arg1	nanostructures					563:576	nanostructures	563:576	nanostructures	563:576	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	33	from	fruits	595:600	arg1	pectins					317:323	three pectins	311:323	three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP))	311:424	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	33	from	fruits	595:600	arg1	pectin					379:384	sodium carbonate-soluble pectin	354:384	sodium carbonate-soluble pectin (SSP)	354:390	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	33	from	fruits	595:600	arg1	characteristics					292:306	characteristics	292:306	characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	292:638	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	33	from	fruits	595:600	arg1	pectin					412:417	chelate-soluble pectin	396:417	chelate-soluble pectin	396:417	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	33	from	fruits	595:600	arg1	compositions					504:515	neutral sugar compositions	490:515	neutral sugar compositions	490:515	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	33	from	fruits	595:600	arg1	pectin					340:345	water-soluble pectin	326:345	water-soluble pectin (WSP)	326:351	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	6	34	from	compositions	1021:1032	arg1	pectins					1043:1049	three pectins	1037:1049	three pectins	1037:1049	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	6	34	from	compositions	1021:1032	arg1	pectins					1097:1103	three pectins	1091:1103	three pectins	1091:1103	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	3	35	theme	pectin	712:717	arg1	characteristics					719:733	pectin characteristics	712:733	pectin characteristics	712:733	The results showed that variation in pectin characteristics during cold storage was similar between DZ and JS.
34146415	9	36	from	structures	1511:1520	arg1	chains					1493:1498	short chains	1487:1498	short chains	1487:1498	AFM images showed an increase in short chains and branch structures of three pectins after storage.
34146415	2	37	theme	degree	453:458	arg1	characteristics					292:306	characteristics	292:306	characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	292:638	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	0	38	from	Changes	0:6	arg1	characteristics					18:32	pectin characteristics	11:32	pectin characteristics of jujube fruits	11:49	Changes in pectin characteristics of jujube fruits cv "Dongzao" and "Jinsixiaozao" during cold storage.
34146415	2	39	theme	nanostructures	563:576	arg1	characteristics					292:306	characteristics	292:306	characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	292:638	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	40	dep	pectins	317:323	arg1	WSP					348:350	WSP	348:350	WSP	348:350	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	40	dep	pectins	317:323	arg1	SSP					387:389	SSP	387:389	SSP	387:389	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	40	dep	pectins	317:323	arg1	pectins					317:323	three pectins	311:323	three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP))	311:424	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	40	dep	pectins	317:323	arg1	pectin					379:384	sodium carbonate-soluble pectin	354:384	sodium carbonate-soluble pectin (SSP)	354:390	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	40	dep	pectins	317:323	arg1	pectin					412:417	chelate-soluble pectin	396:417	chelate-soluble pectin	396:417	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	40	dep	pectins	317:323	arg1	pectin					340:345	water-soluble pectin	326:345	water-soluble pectin (WSP)	326:351	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	40	dep	pectins	317:323	arg1	CSP					420:422	CSP	420:422	CSP	420:422	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	12	41	dep	APPLICATION	1831:1841	arg1	factors					1873:1879	the main factors	1864:1879	the main factors affecting market value and consumer preferences for jujubes	1864:1939	PRACTICAL APPLICATION: Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	12	41	dep	APPLICATION	1831:1841	arg1	related					1961:1967	related	1961:1967	related	1961:1967	PRACTICAL APPLICATION: Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	12	41	dep	APPLICATION	1831:1841	arg1	one					1857:1859	one	1857:1859	one	1857:1859	PRACTICAL APPLICATION: Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	13	42	from	fruits	2239:2244	arg1	nanostructures					2207:2220	nanostructures	2207:2220	nanostructures	2207:2220	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	42	from	fruits	2239:2244	arg1	characteristics					2032:2046	characteristics	2032:2046	characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	2032:2282	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	42	from	fruits	2239:2244	arg1	distributions					2189:2201	the molecular weight distributions	2168:2201	the molecular weight distributions	2168:2201	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	42	from	fruits	2239:2244	arg1	contents					2098:2105	their contents	2092:2105	their contents	2092:2105	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	42	from	fruits	2239:2244	arg1	degree					2108:2113	degree	2108:2113	degree of methylesterification	2108:2137	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	42	from	fruits	2239:2244	arg1	pectins					2057:2063	three pectins	2051:2063	three pectins (WSP, SSP, CSP)	2051:2079	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	42	from	fruits	2239:2244	arg1	compositions					2154:2165	neutral sugar compositions	2140:2165	neutral sugar compositions	2140:2165	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	4	43	theme	water-insoluble	844:858	arg1	pectin					860:865	water-insoluble pectin	844:865	water-insoluble pectin	844:865	The reduction of firmness corresponded to a conversion of water-insoluble pectin to WSP during cold storage.
34146415	8	44	theme	high	1332:1335	arg1	Mw					1337:1338	The high Mw	1328:1338	The high Mw in WSP and SSP of jujubes	1328:1364	The high Mw in WSP and SSP of jujubes were solubilized and extensively depolymerized into pectin with lower Mw after storage.
34146415	2	45	theme	distributions	545:557	arg1	characteristics					292:306	characteristics	292:306	characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	292:638	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	12	46	theme	pectin	2013:2018	arg1	depolymerization					1993:2008	depolymerization	1993:2008	depolymerization	1993:2008	PRACTICAL APPLICATION: Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	12	46	theme	pectin	2013:2018	arg1	modification					1976:1987	modification	1976:1987	modification	1976:1987	PRACTICAL APPLICATION: Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	2	47	theme	jujube	588:593	arg1	JS					636:637	JS	636:637	JS	636:637	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	47	theme	jujube	588:593	arg1	Dongzao					605:611	Dongzao	605:611	Dongzao	605:611	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	47	theme	jujube	588:593	arg1	fruits					595:600	two jujube fruits	584:600	two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	584:638	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	3	48	from	variation	699:707	arg1	characteristics					719:733	pectin characteristics	712:733	pectin characteristics	712:733	The results showed that variation in pectin characteristics during cold storage was similar between DZ and JS.
34146415	0	49	theme	pectin	11:16	arg1	characteristics					18:32	pectin characteristics	11:32	pectin characteristics of jujube fruits	11:49	Changes in pectin characteristics of jujube fruits cv "Dongzao" and "Jinsixiaozao" during cold storage.
34146415	2	50	theme	sodium	354:359	arg1	pectins					317:323	three pectins	311:323	three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP))	311:424	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	50	theme	sodium	354:359	arg1	SSP					387:389	SSP	387:389	SSP	387:389	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	50	theme	sodium	354:359	arg1	pectin					379:384	sodium carbonate-soluble pectin	354:384	sodium carbonate-soluble pectin (SSP)	354:390	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	51	theme	cold	2291:2294	arg1	storage					2296:2302	cold storage	2291:2302	cold storage	2291:2302	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	16	52	theme	cold	2690:2693	arg1	storage					2695:2701	cold storage	2690:2701	cold storage	2690:2701	This study would elucidate the mechanism of jujube softening and help to regulate the postharvest quality during cold storage.
34146415	5	53	theme	WSP	901:903	arg1	DM					895:896	DM	895:896	DM of WSP	895:903	DM of WSP presented an increase trend in the late storage.
34146415	0	54	theme	fruits	44:49	arg1	characteristics					18:32	pectin characteristics	11:32	pectin characteristics of jujube fruits	11:49	Changes in pectin characteristics of jujube fruits cv "Dongzao" and "Jinsixiaozao" during cold storage.
34146415	1	55	theme	pectin	273:278	arg1	modification					236:247	modification	236:247	modification	236:247	Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	1	55	theme	pectin	273:278	arg1	depolymerization					253:268	depolymerization	253:268	depolymerization	253:268	Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	13	56	theme	neutral	2140:2146	arg1	compositions					2154:2165	neutral sugar compositions	2140:2165	neutral sugar compositions	2140:2165	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	57	theme	methylesterification	2118:2137	arg1	nanostructures					2207:2220	nanostructures	2207:2220	nanostructures	2207:2220	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	57	theme	methylesterification	2118:2137	arg1	degree					2108:2113	degree	2108:2113	degree of methylesterification	2108:2137	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	57	theme	methylesterification	2118:2137	arg1	distributions					2189:2201	the molecular weight distributions	2168:2201	the molecular weight distributions	2168:2201	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	57	theme	methylesterification	2118:2137	arg1	contents					2098:2105	their contents	2092:2105	their contents	2092:2105	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	57	theme	methylesterification	2118:2137	arg1	compositions					2154:2165	neutral sugar compositions	2140:2165	neutral sugar compositions	2140:2165	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	58	theme	water-soluble	326:338	arg1	WSP					348:350	WSP	348:350	WSP	348:350	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	58	theme	water-soluble	326:338	arg1	pectins					317:323	three pectins	311:323	three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP))	311:424	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	58	theme	water-soluble	326:338	arg1	pectin					340:345	water-soluble pectin	326:345	water-soluble pectin (WSP)	326:351	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	58	theme	water-soluble	326:338	arg1	CSP					420:422	CSP	420:422	CSP	420:422	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	15	59	theme	fruits	2549:2554	arg1	softening					2529:2537	the softening	2525:2537	the softening of jujube fruits	2525:2554	WSP and SSP were more contributed to the softening of jujubes compared to CSP, and they played the critical role for regulating the softening of jujube fruits during cold storage.
34146415	7	60	from	Changes	1161:1167	arg1	ratio					1176:1180	the ratio	1172:1180	the ratio of (galactose (Gal)+Ara)/Rha and Ara/Gal	1172:1221	Changes in the ratio of (galactose (Gal)+Ara)/Rha and Ara/Gal represented that the branch chains of rhamnogalacturonan-I in three pectins depolymerized after storage.
34146415	14	61	from	pectins	2325:2331	arg1	JS					2343:2344	JS	2343:2344	JS	2343:2344	Three pectins in DZ and JS depolymerized and solubilized during cold storage.
34146415	14	61	from	pectins	2325:2331	arg1	DZ					2336:2337	DZ	2336:2337	DZ	2336:2337	Three pectins in DZ and JS depolymerized and solubilized during cold storage.
34146415	15	62	theme	critical	2496:2503	arg1	role					2505:2508	the critical role	2492:2508	the critical role for regulating the softening of jujube fruits	2492:2554	WSP and SSP were more contributed to the softening of jujubes compared to CSP, and they played the critical role for regulating the softening of jujube fruits during cold storage.
34146415	2	63	theme	pectins	317:323	arg1	characteristics					292:306	characteristics	292:306	characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	292:638	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	6	64	from	compositions	1075:1086	arg1	pectins					1043:1049	three pectins	1037:1049	three pectins	1037:1049	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	6	64	from	compositions	1075:1086	arg1	pectins					1097:1103	three pectins	1091:1103	three pectins	1091:1103	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	9	65	theme	AFM	1454:1456	arg1	images					1458:1463	AFM images	1454:1463	AFM images	1454:1463	AFM images showed an increase in short chains and branch structures of three pectins after storage.
34146415	14	66	theme	cold	2383:2386	arg1	storage					2388:2394	cold storage	2383:2394	cold storage	2383:2394	Three pectins in DZ and JS depolymerized and solubilized during cold storage.
34146415	8	67	theme	lower	1430:1434	arg1	Mw					1436:1437	lower Mw	1430:1437	lower Mw	1430:1437	The high Mw in WSP and SSP of jujubes were solubilized and extensively depolymerized into pectin with lower Mw after storage.
34146415	16	68	theme	softening	2628:2636	arg1	mechanism					2608:2616	the mechanism	2604:2616	the mechanism of jujube softening	2604:2636	This study would elucidate the mechanism of jujube softening and help to regulate the postharvest quality during cold storage.
34146415	13	69	from	characteristics	2032:2046	arg1	fruits					2239:2244	two jujube fruits	2228:2244	two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	2228:2282	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	69	from	characteristics	2032:2046	arg1	JS					2280:2281	JS	2280:2281	JS	2280:2281	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	69	from	characteristics	2032:2046	arg1	Dongzao					2249:2255	Dongzao	2249:2255	Dongzao	2249:2255	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	70	theme	compositions	504:515	arg1	characteristics					292:306	characteristics	292:306	characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	292:638	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	71	theme	cold	647:650	arg1	storage					652:658	cold storage	647:658	cold storage	647:658	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	72	from	Changes	2021:2027	arg1	characteristics					2032:2046	characteristics	2032:2046	characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	2032:2282	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	1	73	theme	main	128:131	arg1	factors					133:139	the main factors	124:139	the main factors affecting market value and consumer preferences for jujubes	124:199	Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	7	74	theme	branch	1244:1249	arg1	chains					1251:1256	the branch chains	1240:1256	the branch chains of rhamnogalacturonan-I in three pectins	1240:1297	Changes in the ratio of (galactose (Gal)+Ara)/Rha and Ara/Gal represented that the branch chains of rhamnogalacturonan-I in three pectins depolymerized after storage.
34146415	12	75	theme	market	1891:1896	arg1	value					1898:1902	market value	1891:1902	market value	1891:1902	PRACTICAL APPLICATION: Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	11	76	theme	cold	1807:1810	arg1	storage					1812:1818	cold storage	1807:1818	cold storage	1807:1818	WSP and SSP were more contributed to the softening of jujubes compared to CSP, and they played the critical role for regulating the softening of jujube fruits during cold storage.
34146415	7	77	from	chains	1251:1256	arg1	pectins					1291:1297	three pectins	1285:1297	three pectins	1285:1297	Changes in the ratio of (galactose (Gal)+Ara)/Rha and Ara/Gal represented that the branch chains of rhamnogalacturonan-I in three pectins depolymerized after storage.
34146415	9	78	theme	short	1487:1491	arg1	chains					1493:1498	short chains	1487:1498	short chains	1487:1498	AFM images showed an increase in short chains and branch structures of three pectins after storage.
34146415	13	79	theme	jujube	2232:2237	arg1	fruits					2239:2244	two jujube fruits	2228:2244	two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	2228:2282	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	79	theme	jujube	2232:2237	arg1	JS					2280:2281	JS	2280:2281	JS	2280:2281	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	79	theme	jujube	2232:2237	arg1	Dongzao					2249:2255	Dongzao	2249:2255	Dongzao	2249:2255	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	11	80	theme	fruits	1793:1798	arg1	softening					1773:1781	the softening	1769:1781	the softening of jujube fruits	1769:1798	WSP and SSP were more contributed to the softening of jujubes compared to CSP, and they played the critical role for regulating the softening of jujube fruits during cold storage.
34146415	1	81	theme	consumer	168:175	arg1	preferences					177:187	consumer preferences	168:187	consumer preferences	168:187	Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	6	82	theme	most	1056:1059	arg1	compositions					1075:1086	most neutral sugar compositions	1056:1086	most neutral sugar compositions	1056:1086	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	12	83	theme	factors	1873:1879	arg1	factors					1873:1879	the main factors	1864:1879	the main factors affecting market value and consumer preferences for jujubes	1864:1939	PRACTICAL APPLICATION: Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	12	83	theme	factors	1873:1879	arg1	one					1857:1859	one	1857:1859	one	1857:1859	PRACTICAL APPLICATION: Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	6	84	theme	cold	1147:1150	arg1	storage					1152:1158	cold storage	1147:1158	cold storage	1147:1158	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	12	85	dep	modification	1976:1987	arg1	the					1972:1974	the	1972:1974	the	1972:1974	PRACTICAL APPLICATION: Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	2	86	theme	neutral	490:496	arg1	compositions					504:515	neutral sugar compositions	490:515	neutral sugar compositions	490:515	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	6	87	dep	compositions	1021:1032	arg1	increased					1111:1119	increased	1111:1119	increased	1111:1119	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	6	87	dep	compositions	1021:1032	arg1	decreased					1130:1138	decreased	1130:1138	decreased during cold storage	1130:1158	Rhamnose (Rha), arabinose (Ara) and glucose (Glc) were the crucial compositions in three pectins, and most neutral sugar compositions in three pectins first increased and then decreased during cold storage.
34146415	13	88	theme	pectins	2057:2063	arg1	characteristics					2032:2046	characteristics	2032:2046	characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	2032:2282	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	89	dep	pectins	2057:2063	arg1	SSP					2071:2073	SSP	2071:2073	SSP	2071:2073	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	89	dep	pectins	2057:2063	arg1	WSP					2066:2068	WSP	2066:2068	WSP	2066:2068	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	89	dep	pectins	2057:2063	arg1	CSP					2076:2078	CSP	2076:2078	CSP	2076:2078	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	0	90	theme	Dongzao	55:61	arg1	"					62:62	"Dongzao"	54:62	"Dongzao"	54:62	Changes in pectin characteristics of jujube fruits cv "Dongzao" and "Jinsixiaozao" during cold storage.
34146415	11	91	theme	critical	1740:1747	arg1	role					1749:1752	the critical role	1736:1752	the critical role for regulating the softening of jujube fruits	1736:1798	WSP and SSP were more contributed to the softening of jujubes compared to CSP, and they played the critical role for regulating the softening of jujube fruits during cold storage.
34146415	3	92	theme	cold	742:745	arg1	storage					747:753	cold storage	742:753	cold storage	742:753	The results showed that variation in pectin characteristics during cold storage was similar between DZ and JS.
34146415	4	93	theme	pectin	860:865	arg1	conversion					830:839	a conversion	828:839	a conversion of water-insoluble pectin to WSP	828:872	The reduction of firmness corresponded to a conversion of water-insoluble pectin to WSP during cold storage.
34146415	1	94	dep	modification	236:247	arg1	the					232:234	the	232:234	the	232:234	Softening is one of the main factors affecting market value and consumer preferences for jujubes, and it was closely related to the modification and depolymerization of pectin.
34146415	13	95	dep	fruits	2239:2244	arg1	fruits					2239:2244	two jujube fruits	2228:2244	two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS)	2228:2282	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	95	dep	fruits	2239:2244	arg1	JS					2280:2281	JS	2280:2281	JS	2280:2281	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	95	dep	fruits	2239:2244	arg1	DZ					2258:2259	DZ	2258:2259	DZ	2258:2259	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	95	dep	fruits	2239:2244	arg1	Dongzao					2249:2255	Dongzao	2249:2255	Dongzao	2249:2255	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	0	96	theme	Jinsixiaozao	69:80	arg1	"					81:81	"Jinsixiaozao"	68:81	"Jinsixiaozao"	68:81	Changes in pectin characteristics of jujube fruits cv "Dongzao" and "Jinsixiaozao" during cold storage.
34146415	13	97	theme	molecular	2172:2180	arg1	distributions					2189:2201	the molecular weight distributions	2168:2201	the molecular weight distributions	2168:2201	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	13	98	theme	weight	2182:2187	arg1	distributions					2189:2201	the molecular weight distributions	2168:2201	the molecular weight distributions	2168:2201	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	11	99	theme	jujubes	1695:1701	arg1	softening					1682:1690	the softening	1678:1690	the softening of jujubes	1678:1701	WSP and SSP were more contributed to the softening of jujubes compared to CSP, and they played the critical role for regulating the softening of jujube fruits during cold storage.
34146415	16	100	theme	postharvest	2663:2673	arg1	quality					2675:2681	the postharvest quality	2659:2681	the postharvest quality	2659:2681	This study would elucidate the mechanism of jujube softening and help to regulate the postharvest quality during cold storage.
34146415	13	101	theme	sugar	2148:2152	arg1	compositions					2154:2165	neutral sugar compositions	2140:2165	neutral sugar compositions	2140:2165	Changes in characteristics of three pectins (WSP, SSP, CSP), including their contents, degree of methylesterification, neutral sugar compositions, the molecular weight distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	102	theme	methylesterification	463:482	arg1	distributions					545:557	the molecular weight (Mw ) distributions	518:557	the molecular weight (Mw ) distributions	518:557	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	102	theme	methylesterification	463:482	arg1	degree					453:458	degree	453:458	degree of methylesterification (DM)	453:487	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	102	theme	methylesterification	463:482	arg1	nanostructures					563:576	nanostructures	563:576	nanostructures	563:576	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	102	theme	methylesterification	463:482	arg1	pectins					317:323	three pectins	311:323	three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP))	311:424	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	102	theme	methylesterification	463:482	arg1	pectin					379:384	sodium carbonate-soluble pectin	354:384	sodium carbonate-soluble pectin (SSP)	354:390	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	102	theme	methylesterification	463:482	arg1	pectin					412:417	chelate-soluble pectin	396:417	chelate-soluble pectin	396:417	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	102	theme	methylesterification	463:482	arg1	compositions					504:515	neutral sugar compositions	490:515	neutral sugar compositions	490:515	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	102	theme	methylesterification	463:482	arg1	pectin					340:345	water-soluble pectin	326:345	water-soluble pectin (WSP)	326:351	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	8	103	theme	jujubes	1358:1364	arg1	SSP					1351:1353	SSP	1351:1353	SSP	1351:1353	The high Mw in WSP and SSP of jujubes were solubilized and extensively depolymerized into pectin with lower Mw after storage.
34146415	8	103	theme	jujubes	1358:1364	arg1	WSP					1343:1345	WSP	1343:1345	WSP	1343:1345	The high Mw in WSP and SSP of jujubes were solubilized and extensively depolymerized into pectin with lower Mw after storage.
34146415	2	104	theme	carbonate-soluble	361:377	arg1	pectins					317:323	three pectins	311:323	three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP))	311:424	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	104	theme	carbonate-soluble	361:377	arg1	SSP					387:389	SSP	387:389	SSP	387:389	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	104	theme	carbonate-soluble	361:377	arg1	pectin					379:384	sodium carbonate-soluble pectin	354:384	sodium carbonate-soluble pectin (SSP)	354:390	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	0	105	theme	jujube	37:42	arg1	fruits					44:49	jujube fruits	37:49	jujube fruits	37:49	Changes in pectin characteristics of jujube fruits cv "Dongzao" and "Jinsixiaozao" during cold storage.
34146415	4	106	theme	cold	881:884	arg1	storage					886:892	cold storage	881:892	cold storage	881:892	The reduction of firmness corresponded to a conversion of water-insoluble pectin to WSP during cold storage.
34146415	8	107	from	Mw	1337:1338	arg1	SSP					1351:1353	SSP	1351:1353	SSP	1351:1353	The high Mw in WSP and SSP of jujubes were solubilized and extensively depolymerized into pectin with lower Mw after storage.
34146415	8	107	from	Mw	1337:1338	arg1	WSP					1343:1345	WSP	1343:1345	WSP	1343:1345	The high Mw in WSP and SSP of jujubes were solubilized and extensively depolymerized into pectin with lower Mw after storage.
34146415	2	108	theme	chelate-soluble	396:410	arg1	pectin					412:417	chelate-soluble pectin	396:417	chelate-soluble pectin	396:417	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	2	108	theme	chelate-soluble	396:410	arg1	pectins					317:323	three pectins	311:323	three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP))	311:424	Changes in characteristics of three pectins (water-soluble pectin (WSP), sodium carbonate-soluble pectin (SSP) and chelate-soluble pectin (CSP)), including their contents, degree of methylesterification (DM), neutral sugar compositions, the molecular weight (Mw ) distributions and nanostructures, from two jujube fruits cv Dongzao (DZ) and Jinsixiaozao (JS) during cold storage were assessed.
34146415	10	109	dep	depolymerized	1590:1602	arg1	solubilized					1608:1618	solubilized	1608:1618	solubilized during cold storage	1608:1638	Overall, three pectins in DZ and JS depolymerized and solubilized during cold storage.
34906282	5	0	theme	HA-CeO₂	765:771	arg1	higher					777:782	higher	777:782	higher	777:782	The infiltration efficiency of HA-CeO₂ was higher than that of PEI-CeO₂.
34906282	5	0	theme	HA-CeO₂	765:771	arg1	efficiency					751:760	The infiltration efficiency	734:760	The infiltration efficiency of HA-CeO₂	734:771	The infiltration efficiency of HA-CeO₂ was higher than that of PEI-CeO₂.
34906282	7	1	theme	HA-CeO₂	972:978	arg1	superior					1113:1120	superior	1113:1120	superior	1113:1120	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	7	1	theme	HA-CeO₂	972:978	arg1	efficacy					960:967	The clinical efficacy	947:967	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations	947:1107	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	3	2	theme	cell	489:492	arg1	infiltration					494:505	immune cell infiltration	482:505	immune cell infiltration	482:505	We investigated the transport performance, histolysis, immune cell infiltration, angiogenesis, and hyperemia induced by the transport system.
34906282	3	2	theme	cell	489:492	arg1	performance					457:467	the transport performance	443:467	the transport performance	443:467	We investigated the transport performance, histolysis, immune cell infiltration, angiogenesis, and hyperemia induced by the transport system.
34906282	8	3	theme	injury	1212:1217	arg1	capacity					1219:1226	significant antioxidation and anti-vascular injury capacity	1168:1226	capacity	1219:1226	HA-CeO₂ was shown to have significant antioxidation and anti-vascular injury capacity in a mouse model, and may be a potential compound nanodrug for DR treatment in the future.
34906282	6	4	theme	cell	899:902	arg1	infiltration					904:915	immune cell infiltration	892:915	immune cell infiltration	892:915	Lower levels of foreign body reaction were evident for HA-CeO₂ with less histolysis, immune cell infiltration, angiogenesis, and hyperemia.
34906282	7	5	theme	clinical	951:958	arg1	superior					1113:1120	superior	1113:1120	superior	1113:1120	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	7	5	theme	clinical	951:958	arg1	efficacy					960:967	The clinical efficacy	947:967	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations	947:1107	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	1	6	theme	diabetic	205:212	arg1	-CeO₂					252:256	hyaluronic acid (HA)-CeO₂	232:256	hyaluronic acid (HA)-CeO₂	232:256	We developed an effective nanoparticle-biomaterial in alleviating diabetic retinopathy (DR), hyaluronic acid (HA)-CeO₂, composed mainly of CeO₂ and HA.
34906282	1	6	theme	diabetic	205:212	arg1	DR					227:228	DR	227:228	DR	227:228	We developed an effective nanoparticle-biomaterial in alleviating diabetic retinopathy (DR), hyaluronic acid (HA)-CeO₂, composed mainly of CeO₂ and HA.
34906282	1	6	theme	diabetic	205:212	arg1	retinopathy					214:224	diabetic retinopathy	205:224	diabetic retinopathy (DR)	205:229	We developed an effective nanoparticle-biomaterial in alleviating diabetic retinopathy (DR), hyaluronic acid (HA)-CeO₂, composed mainly of CeO₂ and HA.
34906282	0	7	theme	Retinopathy	114:124	arg1	Alleviation					126:136	Diabetic Retinopathy Alleviation	105:136	Diabetic Retinopathy Alleviation	105:136	Construction of Hyaluronic Acid-CeO₂ Conjugated Composite Nanoparticles and Their Activity Efficiency in Diabetic Retinopathy Alleviation.
34906282	6	8	theme	immune	892:897	arg1	infiltration					904:915	immune cell infiltration	892:915	immune cell infiltration	892:915	Lower levels of foreign body reaction were evident for HA-CeO₂ with less histolysis, immune cell infiltration, angiogenesis, and hyperemia.
34906282	6	9	theme	Lower	807:811	arg1	levels					813:818	Lower levels	807:818	Lower levels of foreign body reaction	807:843	Lower levels of foreign body reaction were evident for HA-CeO₂ with less histolysis, immune cell infiltration, angiogenesis, and hyperemia.
34906282	0	10	theme	Diabetic	105:112	arg1	Retinopathy					114:124	Diabetic Retinopathy	105:124	Diabetic Retinopathy Alleviation	105:136	Construction of Hyaluronic Acid-CeO₂ Conjugated Composite Nanoparticles and Their Activity Efficiency in Diabetic Retinopathy Alleviation.
34906282	2	11	theme	B6/J	349:352	arg1	model					360:364	a B6/J mouse model	347:364	a B6/J mouse model	347:364	To demonstrate its anti-DR capacity, retinal cells from a B6/J mouse model were used to compare the efficiency of PEI-CeO₂ and HA-CeO₂.
34906282	4	12	theme	structural	573:582	arg1	integrity					584:592	structural integrity	573:592	structural integrity	573:592	The structural integrity, microvascular apoptosis, and superoxide and peroxide concentrations in the retina were measured to evaluate the clinical efficacy of CeO₂.
34906282	8	13	theme	significant	1168:1178	arg1	antioxidation					1180:1192	significant antioxidation and anti-vascular injury capacity	1168:1226	antioxidation	1180:1192	HA-CeO₂ was shown to have significant antioxidation and anti-vascular injury capacity in a mouse model, and may be a potential compound nanodrug for DR treatment in the future.
34906282	0	14	from	Nanoparticles	58:70	arg1	Alleviation					126:136	Diabetic Retinopathy Alleviation	105:136	Diabetic Retinopathy Alleviation	105:136	Construction of Hyaluronic Acid-CeO₂ Conjugated Composite Nanoparticles and Their Activity Efficiency in Diabetic Retinopathy Alleviation.
34906282	7	15	theme	concentrations	1094:1107	arg1	lowering					1030:1037	lowering	1030:1037	lowering of microvascular apoptosis and superoxide and peroxide concentrations	1030:1107	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	7	15	theme	concentrations	1094:1107	arg1	structure					1016:1024	retinal structure	1008:1024	retinal structure	1008:1024	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	8	16	from	nanodrug	1278:1285	arg1	future					1311:1316	future	1311:1316	future	1311:1316	HA-CeO₂ was shown to have significant antioxidation and anti-vascular injury capacity in a mouse model, and may be a potential compound nanodrug for DR treatment in the future.
34906282	8	17	theme	anti-vascular	1198:1210	arg1	capacity					1219:1226	significant antioxidation and anti-vascular injury capacity	1168:1226	capacity	1219:1226	HA-CeO₂ was shown to have significant antioxidation and anti-vascular injury capacity in a mouse model, and may be a potential compound nanodrug for DR treatment in the future.
34906282	6	18	with	evident	850:856	arg1	histolysis					880:889	histolysis	880:889	histolysis	880:889	Lower levels of foreign body reaction were evident for HA-CeO₂ with less histolysis, immune cell infiltration, angiogenesis, and hyperemia.
34906282	6	18	with	evident	850:856	arg1	angiogenesis					918:929	angiogenesis	918:929	angiogenesis	918:929	Lower levels of foreign body reaction were evident for HA-CeO₂ with less histolysis, immune cell infiltration, angiogenesis, and hyperemia.
34906282	6	18	with	evident	850:856	arg1	hyperemia					936:944	hyperemia	936:944	hyperemia	936:944	Lower levels of foreign body reaction were evident for HA-CeO₂ with less histolysis, immune cell infiltration, angiogenesis, and hyperemia.
34906282	6	18	with	evident	850:856	arg1	infiltration					904:915	immune cell infiltration	892:915	immune cell infiltration	892:915	Lower levels of foreign body reaction were evident for HA-CeO₂ with less histolysis, immune cell infiltration, angiogenesis, and hyperemia.
34906282	5	19	theme	infiltration	738:749	arg1	higher					777:782	higher	777:782	higher	777:782	The infiltration efficiency of HA-CeO₂ was higher than that of PEI-CeO₂.
34906282	5	19	theme	infiltration	738:749	arg1	efficiency					751:760	The infiltration efficiency	734:760	The infiltration efficiency of HA-CeO₂	734:771	The infiltration efficiency of HA-CeO₂ was higher than that of PEI-CeO₂.
34906282	3	20	theme	transport	551:559	arg1	system					561:566	the transport system	547:566	the transport system	547:566	We investigated the transport performance, histolysis, immune cell infiltration, angiogenesis, and hyperemia induced by the transport system.
34906282	4	21	from	concentrations	648:661	arg1	retina					670:675	the retina	666:675	the retina	666:675	The structural integrity, microvascular apoptosis, and superoxide and peroxide concentrations in the retina were measured to evaluate the clinical efficacy of CeO₂.
34906282	4	22	theme	peroxide	639:646	arg1	concentrations					648:661	superoxide and peroxide concentrations	624:661	superoxide and peroxide concentrations	624:661	The structural integrity, microvascular apoptosis, and superoxide and peroxide concentrations in the retina were measured to evaluate the clinical efficacy of CeO₂.
34906282	7	23	theme	peroxide	1085:1092	arg1	concentrations					1094:1107	superoxide and peroxide concentrations	1070:1107	superoxide and peroxide concentrations	1070:1107	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	2	24	from	model	360:364	arg1	cells					336:340	retinal cells	328:340	retinal cells from a B6/J mouse model	328:364	To demonstrate its anti-DR capacity, retinal cells from a B6/J mouse model were used to compare the efficiency of PEI-CeO₂ and HA-CeO₂.
34906282	2	25	theme	anti-DR	310:316	arg1	capacity					318:325	its anti-DR capacity	306:325	its anti-DR capacity	306:325	To demonstrate its anti-DR capacity, retinal cells from a B6/J mouse model were used to compare the efficiency of PEI-CeO₂ and HA-CeO₂.
34906282	2	26	theme	HA-CeO₂	418:424	arg1	efficiency					391:400	the efficiency	387:400	the efficiency of PEI-CeO₂ and HA-CeO₂	387:424	To demonstrate its anti-DR capacity, retinal cells from a B6/J mouse model were used to compare the efficiency of PEI-CeO₂ and HA-CeO₂.
34906282	4	27	theme	CeO₂	728:731	arg1	efficacy					716:723	the clinical efficacy	703:723	the clinical efficacy of CeO₂	703:731	The structural integrity, microvascular apoptosis, and superoxide and peroxide concentrations in the retina were measured to evaluate the clinical efficacy of CeO₂.
34906282	3	28	theme	transport	447:455	arg1	hyperemia					526:534	hyperemia	526:534	hyperemia	526:534	We investigated the transport performance, histolysis, immune cell infiltration, angiogenesis, and hyperemia induced by the transport system.
34906282	3	28	theme	transport	447:455	arg1	infiltration					494:505	immune cell infiltration	482:505	immune cell infiltration	482:505	We investigated the transport performance, histolysis, immune cell infiltration, angiogenesis, and hyperemia induced by the transport system.
34906282	3	28	theme	transport	447:455	arg1	angiogenesis					508:519	angiogenesis	508:519	angiogenesis	508:519	We investigated the transport performance, histolysis, immune cell infiltration, angiogenesis, and hyperemia induced by the transport system.
34906282	3	28	theme	transport	447:455	arg1	histolysis					470:479	histolysis	470:479	histolysis	470:479	We investigated the transport performance, histolysis, immune cell infiltration, angiogenesis, and hyperemia induced by the transport system.
34906282	3	28	theme	transport	447:455	arg1	performance					457:467	the transport performance	443:467	the transport performance	443:467	We investigated the transport performance, histolysis, immune cell infiltration, angiogenesis, and hyperemia induced by the transport system.
34906282	0	29	theme	Hyaluronic	16:25	arg1	Acid-CeO₂					27:35	Hyaluronic Acid-CeO₂	16:35	Hyaluronic Acid-CeO₂	16:35	Construction of Hyaluronic Acid-CeO₂ Conjugated Composite Nanoparticles and Their Activity Efficiency in Diabetic Retinopathy Alleviation.
34906282	7	30	theme	superoxide	1070:1079	arg1	concentrations					1094:1107	superoxide and peroxide concentrations	1070:1107	superoxide and peroxide concentrations	1070:1107	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	4	31	dep	integrity	584:592	arg1	The					569:571	The	569:571	The	569:571	The structural integrity, microvascular apoptosis, and superoxide and peroxide concentrations in the retina were measured to evaluate the clinical efficacy of CeO₂.
34906282	7	32	from	efficacy	960:967	arg1	terms					983:987	terms	983:987	terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations	983:1107	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	1	33	theme	hyaluronic	232:241	arg1	HA					249:250	HA	249:250	HA	249:250	We developed an effective nanoparticle-biomaterial in alleviating diabetic retinopathy (DR), hyaluronic acid (HA)-CeO₂, composed mainly of CeO₂ and HA.
34906282	1	33	theme	hyaluronic	232:241	arg1	acid					243:246	hyaluronic acid	232:246	hyaluronic acid (HA)-CeO₂	232:256	We developed an effective nanoparticle-biomaterial in alleviating diabetic retinopathy (DR), hyaluronic acid (HA)-CeO₂, composed mainly of CeO₂ and HA.
34906282	0	34	theme	Composite	48:56	arg1	Nanoparticles					58:70	Composite Nanoparticles	48:70	Composite Nanoparticles	48:70	Construction of Hyaluronic Acid-CeO₂ Conjugated Composite Nanoparticles and Their Activity Efficiency in Diabetic Retinopathy Alleviation.
34906282	7	35	theme	microvascular	1042:1054	arg1	apoptosis					1056:1064	microvascular apoptosis	1042:1064	microvascular apoptosis	1042:1064	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	0	36	from	Efficiency	91:100	arg1	Alleviation					126:136	Diabetic Retinopathy Alleviation	105:136	Diabetic Retinopathy Alleviation	105:136	Construction of Hyaluronic Acid-CeO₂ Conjugated Composite Nanoparticles and Their Activity Efficiency in Diabetic Retinopathy Alleviation.
34906282	1	37	theme	acid	243:246	arg1	-CeO₂					252:256	hyaluronic acid (HA)-CeO₂	232:256	hyaluronic acid (HA)-CeO₂	232:256	We developed an effective nanoparticle-biomaterial in alleviating diabetic retinopathy (DR), hyaluronic acid (HA)-CeO₂, composed mainly of CeO₂ and HA.
34906282	1	37	theme	acid	243:246	arg1	retinopathy					214:224	diabetic retinopathy	205:224	diabetic retinopathy (DR)	205:229	We developed an effective nanoparticle-biomaterial in alleviating diabetic retinopathy (DR), hyaluronic acid (HA)-CeO₂, composed mainly of CeO₂ and HA.
34906282	7	38	theme	apoptosis	1056:1064	arg1	lowering					1030:1037	lowering	1030:1037	lowering of microvascular apoptosis and superoxide and peroxide concentrations	1030:1107	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	7	38	theme	apoptosis	1056:1064	arg1	structure					1016:1024	retinal structure	1008:1024	retinal structure	1008:1024	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	8	39	theme	compound	1269:1276	arg1	nanodrug					1278:1285	a potential compound nanodrug	1257:1285	a potential compound nanodrug for DR treatment	1257:1302	HA-CeO₂ was shown to have significant antioxidation and anti-vascular injury capacity in a mouse model, and may be a potential compound nanodrug for DR treatment in the future.
34906282	0	40	theme	Acid-CeO₂	27:35	arg1	Construction					0:11	Construction	0:11	Construction of Hyaluronic Acid-CeO₂	0:35	Construction of Hyaluronic Acid-CeO₂ Conjugated Composite Nanoparticles and Their Activity Efficiency in Diabetic Retinopathy Alleviation.
34906282	8	41	theme	DR	1291:1292	arg1	treatment					1294:1302	DR treatment	1291:1302	DR treatment	1291:1302	HA-CeO₂ was shown to have significant antioxidation and anti-vascular injury capacity in a mouse model, and may be a potential compound nanodrug for DR treatment in the future.
34906282	8	42	theme	mouse	1233:1237	arg1	model					1239:1243	a mouse model	1231:1243	a mouse model	1231:1243	HA-CeO₂ was shown to have significant antioxidation and anti-vascular injury capacity in a mouse model, and may be a potential compound nanodrug for DR treatment in the future.
34906282	4	43	from	integrity	584:592	arg1	retina					670:675	the retina	666:675	the retina	666:675	The structural integrity, microvascular apoptosis, and superoxide and peroxide concentrations in the retina were measured to evaluate the clinical efficacy of CeO₂.
34906282	7	44	theme	lowering	1030:1037	arg1	preservation					992:1003	preservation	992:1003	preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations	992:1107	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	7	45	theme	retinal	1008:1014	arg1	structure					1016:1024	retinal structure	1008:1024	retinal structure	1008:1024	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	4	46	theme	clinical	707:714	arg1	efficacy					716:723	the clinical efficacy	703:723	the clinical efficacy of CeO₂	703:731	The structural integrity, microvascular apoptosis, and superoxide and peroxide concentrations in the retina were measured to evaluate the clinical efficacy of CeO₂.
34906282	6	47	theme	reaction	836:843	arg1	levels					813:818	Lower levels	807:818	Lower levels of foreign body reaction	807:843	Lower levels of foreign body reaction were evident for HA-CeO₂ with less histolysis, immune cell infiltration, angiogenesis, and hyperemia.
34906282	3	48	theme	immune	482:487	arg1	infiltration					494:505	immune cell infiltration	482:505	immune cell infiltration	482:505	We investigated the transport performance, histolysis, immune cell infiltration, angiogenesis, and hyperemia induced by the transport system.
34906282	3	48	theme	immune	482:487	arg1	performance					457:467	the transport performance	443:467	the transport performance	443:467	We investigated the transport performance, histolysis, immune cell infiltration, angiogenesis, and hyperemia induced by the transport system.
34906282	7	49	theme	structure	1016:1024	arg1	preservation					992:1003	preservation	992:1003	preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations	992:1107	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	6	50	theme	body	831:834	arg1	reaction					836:843	foreign body reaction	823:843	foreign body reaction	823:843	Lower levels of foreign body reaction were evident for HA-CeO₂ with less histolysis, immune cell infiltration, angiogenesis, and hyperemia.
34906282	7	51	theme	preservation	992:1003	arg1	terms					983:987	terms	983:987	terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations	983:1107	The clinical efficacy of HA-CeO₂ in terms of preservation of retinal structure and lowering of microvascular apoptosis and superoxide and peroxide concentrations was superior to those of PEI-CP.
34906282	2	52	theme	retinal	328:334	arg1	cells					336:340	retinal cells	328:340	retinal cells from a B6/J mouse model	328:364	To demonstrate its anti-DR capacity, retinal cells from a B6/J mouse model were used to compare the efficiency of PEI-CeO₂ and HA-CeO₂.
34906282	4	53	theme	microvascular	595:607	arg1	apoptosis					609:617	microvascular apoptosis	595:617	microvascular apoptosis	595:617	The structural integrity, microvascular apoptosis, and superoxide and peroxide concentrations in the retina were measured to evaluate the clinical efficacy of CeO₂.
34906282	6	54	theme	foreign	823:829	arg1	reaction					836:843	foreign body reaction	823:843	foreign body reaction	823:843	Lower levels of foreign body reaction were evident for HA-CeO₂ with less histolysis, immune cell infiltration, angiogenesis, and hyperemia.
34906282	2	55	theme	PEI-CeO₂	405:412	arg1	efficiency					391:400	the efficiency	387:400	the efficiency of PEI-CeO₂ and HA-CeO₂	387:424	To demonstrate its anti-DR capacity, retinal cells from a B6/J mouse model were used to compare the efficiency of PEI-CeO₂ and HA-CeO₂.
34906282	1	56	theme	effective	155:163	arg1	nanoparticle-biomaterial					165:188	an effective nanoparticle-biomaterial	152:188	an effective nanoparticle-biomaterial	152:188	We developed an effective nanoparticle-biomaterial in alleviating diabetic retinopathy (DR), hyaluronic acid (HA)-CeO₂, composed mainly of CeO₂ and HA.
34906282	0	57	theme	Activity	82:89	arg1	Efficiency					91:100	Their Activity Efficiency	76:100	Their Activity Efficiency	76:100	Construction of Hyaluronic Acid-CeO₂ Conjugated Composite Nanoparticles and Their Activity Efficiency in Diabetic Retinopathy Alleviation.
34906282	8	58	theme	potential	1259:1267	arg1	nanodrug					1278:1285	a potential compound nanodrug	1257:1285	a potential compound nanodrug for DR treatment	1257:1302	HA-CeO₂ was shown to have significant antioxidation and anti-vascular injury capacity in a mouse model, and may be a potential compound nanodrug for DR treatment in the future.
34906282	2	59	used	used	371:374	arg2	cells					336:340	retinal cells	328:340	retinal cells from a B6/J mouse model	328:364	To demonstrate its anti-DR capacity, retinal cells from a B6/J mouse model were used to compare the efficiency of PEI-CeO₂ and HA-CeO₂.
34906282	4	60	from	apoptosis	609:617	arg1	retina					670:675	the retina	666:675	the retina	666:675	The structural integrity, microvascular apoptosis, and superoxide and peroxide concentrations in the retina were measured to evaluate the clinical efficacy of CeO₂.
34906282	4	61	theme	superoxide	624:633	arg1	concentrations					648:661	superoxide and peroxide concentrations	624:661	superoxide and peroxide concentrations	624:661	The structural integrity, microvascular apoptosis, and superoxide and peroxide concentrations in the retina were measured to evaluate the clinical efficacy of CeO₂.
34906282	2	62	theme	mouse	354:358	arg1	model					360:364	a B6/J mouse model	347:364	a B6/J mouse model	347:364	To demonstrate its anti-DR capacity, retinal cells from a B6/J mouse model were used to compare the efficiency of PEI-CeO₂ and HA-CeO₂.
33191212	3	0	from	microflora	505:514	arg1	mice					519:522	mice	519:522	mice	519:522	In this study, ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods were combined to explore the prebiotic-like effects of CS on the intestinal microflora in mice.
33191212	2	1	contain	possesses	224:232	arg1	CS					220:221	CS	220:221	CS	220:221	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	2	1	contain	possesses	224:232	arg1	Chitosan					210:217	Chitosan	210:217	Chitosan (CS)	210:222	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	2	1	contain	possesses	224:232	arg1	source					308:313	a new source	302:313	a new source of prebiotic	302:326	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	2	1	contain	possesses	224:232	arg2	effects					273:279	diverse biological and pharmacological effects	234:279	diverse biological and pharmacological effects	234:279	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	8	2	theme	intestinal	1248:1257	arg1	microflora					1259:1268	intestinal microflora	1248:1268	intestinal microflora	1248:1268	Together, our results demonstrated that CS could be regarded as a potential food supplement for protecting intestinal microflora and regulate imbalance.
33191212	0	3	from	effects	15:21	arg1	microflora					53:62	the intestinal microflora	38:62	the intestinal microflora in mice	38:70	Prebiotic-like effects of chitosan on the intestinal microflora in mice.
33191212	3	4	dep	ERIC	344:347	arg1	Consensus					388:396	Enterobacterial Repetitive Intergenic Consensus	350:396	Enterobacterial Repetitive Intergenic Consensus	350:396	In this study, ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods were combined to explore the prebiotic-like effects of CS on the intestinal microflora in mice.
33191212	3	5	theme	CS	484:485	arg1	effects					473:479	the prebiotic-like effects	454:479	the prebiotic-like effects of CS on the intestinal microflora in mice	454:522	In this study, ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods were combined to explore the prebiotic-like effects of CS on the intestinal microflora in mice.
33191212	3	6	theme	Enterobacterial	350:364	arg1	Consensus					388:396	Enterobacterial Repetitive Intergenic Consensus	350:396	Enterobacterial Repetitive Intergenic Consensus	350:396	In this study, ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods were combined to explore the prebiotic-like effects of CS on the intestinal microflora in mice.
33191212	0	7	from	microflora	53:62	arg1	mice					67:70	mice	67:70	mice	67:70	Prebiotic-like effects of chitosan on the intestinal microflora in mice.
33191212	6	8	theme	Viable	718:723	arg1	counts					725:730	Viable counts	718:730	Viable counts method	718:737	Viable counts method indicated the growth of Lactobacillus was promoted with CS treatment while at the same time Enterobacteria and Enterococcus were inhibited.
33191212	2	9	theme	new	304:306	arg1	Chitosan					210:217	Chitosan	210:217	Chitosan (CS)	210:222	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	2	9	theme	new	304:306	arg1	source					308:313	a new source	302:313	a new source of prebiotic	302:326	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	7	10	theme	CS-treated	1122:1131	arg1	groups					1133:1138	the control and long-term CS-treated groups	1096:1138	the control and long-term CS-treated groups	1096:1138	ERIC-PCR fingerprint, UPGMA dendrogram, PCA and diversity analysis showed that the intestinal microflora composition was changed with antibiotics treatment, and that samples were significantly separated from those of the control and long-term CS-treated groups.
33191212	3	11	theme	prebiotic-like	458:471	arg1	effects					473:479	the prebiotic-like effects	454:479	the prebiotic-like effects of CS on the intestinal microflora in mice	454:522	In this study, ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods were combined to explore the prebiotic-like effects of CS on the intestinal microflora in mice.
33191212	7	12	theme	ERIC-PCR	879:886	arg1	fingerprint					888:898	ERIC-PCR fingerprint	879:898	ERIC-PCR fingerprint	879:898	ERIC-PCR fingerprint, UPGMA dendrogram, PCA and diversity analysis showed that the intestinal microflora composition was changed with antibiotics treatment, and that samples were significantly separated from those of the control and long-term CS-treated groups.
33191212	3	13	theme	intestinal	494:503	arg1	microflora					505:514	the intestinal microflora	490:514	the intestinal microflora in mice	490:522	In this study, ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods were combined to explore the prebiotic-like effects of CS on the intestinal microflora in mice.
33191212	1	14	theme	potential	161:169	arg1	capacity					171:178	the potential capacity	157:178	the potential capacity of improving the host health	157:207	Food supplements can modulate the composition of human intestinal microflora due to the potential capacity of improving the host health.
33191212	0	15	theme	intestinal	42:51	arg1	microflora					53:62	the intestinal microflora	38:62	the intestinal microflora in mice	38:70	Prebiotic-like effects of chitosan on the intestinal microflora in mice.
33191212	6	16	theme	Lactobacillus	763:775	arg1	growth					753:758	the growth	749:758	the growth of Lactobacillus	749:775	Viable counts method indicated the growth of Lactobacillus was promoted with CS treatment while at the same time Enterobacteria and Enterococcus were inhibited.
33191212	1	17	theme	Food	73:76	arg1	supplements					78:88	Food supplements	73:88	Food supplements	73:88	Food supplements can modulate the composition of human intestinal microflora due to the potential capacity of improving the host health.
33191212	3	18	theme	counts	414:419	arg1	methods					421:427	ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods	344:427	ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods	344:427	In this study, ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods were combined to explore the prebiotic-like effects of CS on the intestinal microflora in mice.
33191212	6	19	theme	CS	795:796	arg1	treatment					798:806	CS treatment	795:806	CS treatment	795:806	Viable counts method indicated the growth of Lactobacillus was promoted with CS treatment while at the same time Enterobacteria and Enterococcus were inhibited.
33191212	7	20	theme	antibiotics	1013:1023	arg1	treatment					1025:1033	antibiotics treatment	1013:1033	antibiotics treatment	1013:1033	ERIC-PCR fingerprint, UPGMA dendrogram, PCA and diversity analysis showed that the intestinal microflora composition was changed with antibiotics treatment, and that samples were significantly separated from those of the control and long-term CS-treated groups.
33191212	3	21	theme	-PCR	398:401	arg1	methods					421:427	ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods	344:427	ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods	344:427	In this study, ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods were combined to explore the prebiotic-like effects of CS on the intestinal microflora in mice.
33191212	0	22	theme	Prebiotic-like	0:13	arg1	effects					15:21	Prebiotic-like effects	0:21	Prebiotic-like effects of chitosan on the intestinal microflora in mice	0:70	Prebiotic-like effects of chitosan on the intestinal microflora in mice.
33191212	0	23	theme	chitosan	26:33	arg1	effects					15:21	Prebiotic-like effects	0:21	Prebiotic-like effects of chitosan on the intestinal microflora in mice	0:70	Prebiotic-like effects of chitosan on the intestinal microflora in mice.
33191212	3	24	from	effects	473:479	arg1	microflora					505:514	the intestinal microflora	490:514	the intestinal microflora in mice	490:522	In this study, ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods were combined to explore the prebiotic-like effects of CS on the intestinal microflora in mice.
33191212	3	25	theme	ERIC	344:347	arg1	-PCR					398:401	ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR	344:401	ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR	344:401	In this study, ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods were combined to explore the prebiotic-like effects of CS on the intestinal microflora in mice.
33191212	1	26	theme	host	197:200	arg1	health					202:207	the host health	193:207	the host health	193:207	Food supplements can modulate the composition of human intestinal microflora due to the potential capacity of improving the host health.
33191212	6	27	dep	time	826:829	arg1	Enterococcus					850:861	Enterococcus	850:861	Enterococcus	850:861	Viable counts method indicated the growth of Lactobacillus was promoted with CS treatment while at the same time Enterobacteria and Enterococcus were inhibited.
33191212	6	27	dep	time	826:829	arg1	Enterobacteria					831:844	Enterobacteria	831:844	Enterobacteria	831:844	Viable counts method indicated the growth of Lactobacillus was promoted with CS treatment while at the same time Enterobacteria and Enterococcus were inhibited.
33191212	7	28	theme	long-term	1112:1120	arg1	groups					1133:1138	the control and long-term CS-treated groups	1096:1138	the control and long-term CS-treated groups	1096:1138	ERIC-PCR fingerprint, UPGMA dendrogram, PCA and diversity analysis showed that the intestinal microflora composition was changed with antibiotics treatment, and that samples were significantly separated from those of the control and long-term CS-treated groups.
33191212	8	29	theme	potential	1207:1215	arg1	supplement					1222:1231	a potential food supplement	1205:1231	a potential food supplement for protecting intestinal microflora and regulate imbalance	1205:1291	Together, our results demonstrated that CS could be regarded as a potential food supplement for protecting intestinal microflora and regulate imbalance.
33191212	8	29	theme	potential	1207:1215	arg1	CS					1181:1182	CS	1181:1182	CS	1181:1182	Together, our results demonstrated that CS could be regarded as a potential food supplement for protecting intestinal microflora and regulate imbalance.
33191212	2	30	dep	diverse	234:240	arg1	biological					242:251	biological	242:251	biological	242:251	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	3	31	theme	Repetitive	366:375	arg1	Consensus					388:396	Enterobacterial Repetitive Intergenic Consensus	350:396	Enterobacterial Repetitive Intergenic Consensus	350:396	In this study, ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods were combined to explore the prebiotic-like effects of CS on the intestinal microflora in mice.
33191212	7	32	theme	intestinal	962:971	arg1	microflora					973:982	the intestinal microflora	958:982	the intestinal microflora composition	958:994	ERIC-PCR fingerprint, UPGMA dendrogram, PCA and diversity analysis showed that the intestinal microflora composition was changed with antibiotics treatment, and that samples were significantly separated from those of the control and long-term CS-treated groups.
33191212	3	33	theme	viable	407:412	arg1	counts					414:419	viable counts	407:419	viable counts	407:419	In this study, ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods were combined to explore the prebiotic-like effects of CS on the intestinal microflora in mice.
33191212	2	34	theme	prebiotic	318:326	arg1	Chitosan					210:217	Chitosan	210:217	Chitosan (CS)	210:222	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	2	34	theme	prebiotic	318:326	arg1	source					308:313	a new source	302:313	a new source of prebiotic	302:326	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	3	35	theme	Intergenic	377:386	arg1	Consensus					388:396	Enterobacterial Repetitive Intergenic Consensus	350:396	Enterobacterial Repetitive Intergenic Consensus	350:396	In this study, ERIC (Enterobacterial Repetitive Intergenic Consensus)-PCR and viable counts methods were combined to explore the prebiotic-like effects of CS on the intestinal microflora in mice.
33191212	7	36	theme	microflora	973:982	arg1	composition					984:994	the intestinal microflora composition	958:994	the intestinal microflora composition	958:994	ERIC-PCR fingerprint, UPGMA dendrogram, PCA and diversity analysis showed that the intestinal microflora composition was changed with antibiotics treatment, and that samples were significantly separated from those of the control and long-term CS-treated groups.
33191212	6	37	theme	same	821:824	arg1	time					826:829	the same time Enterobacteria and Enterococcus	817:861	the same time Enterobacteria and Enterococcus	817:861	Viable counts method indicated the growth of Lactobacillus was promoted with CS treatment while at the same time Enterobacteria and Enterococcus were inhibited.
33191212	8	38	theme	food	1217:1220	arg1	supplement					1222:1231	a potential food supplement	1205:1231	a potential food supplement for protecting intestinal microflora and regulate imbalance	1205:1291	Together, our results demonstrated that CS could be regarded as a potential food supplement for protecting intestinal microflora and regulate imbalance.
33191212	8	38	theme	food	1217:1220	arg1	CS					1181:1182	CS	1181:1182	CS	1181:1182	Together, our results demonstrated that CS could be regarded as a potential food supplement for protecting intestinal microflora and regulate imbalance.
33191212	6	39	dep	promoted	781:788	arg1	indicated					739:747	indicated	739:747	indicated	739:747	Viable counts method indicated the growth of Lactobacillus was promoted with CS treatment while at the same time Enterobacteria and Enterococcus were inhibited.
33191212	6	40	theme	counts	725:730	arg1	method					732:737	Viable counts method	718:737	Viable counts method	718:737	Viable counts method indicated the growth of Lactobacillus was promoted with CS treatment while at the same time Enterobacteria and Enterococcus were inhibited.
33191212	1	41	theme	human	122:126	arg1	microflora					139:148	human intestinal microflora	122:148	human intestinal microflora	122:148	Food supplements can modulate the composition of human intestinal microflora due to the potential capacity of improving the host health.
33191212	2	42	used	used	294:297	arg2	Chitosan					210:217	Chitosan	210:217	Chitosan (CS)	210:222	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	2	42	used	used	294:297	arg2	source					308:313	a new source	302:313	a new source of prebiotic	302:326	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	2	42	used	used	294:297	arg2	CS					220:221	CS	220:221	CS	220:221	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	2	43	theme	pharmacological	257:271	arg1	effects					273:279	diverse biological and pharmacological effects	234:279	diverse biological and pharmacological effects	234:279	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	1	44	theme	intestinal	128:137	arg1	microflora					139:148	human intestinal microflora	122:148	human intestinal microflora	122:148	Food supplements can modulate the composition of human intestinal microflora due to the potential capacity of improving the host health.
33191212	7	45	theme	diversity	927:935	arg1	analysis					937:944	diversity analysis	927:944	diversity analysis	927:944	ERIC-PCR fingerprint, UPGMA dendrogram, PCA and diversity analysis showed that the intestinal microflora composition was changed with antibiotics treatment, and that samples were significantly separated from those of the control and long-term CS-treated groups.
33191212	2	46	theme	diverse	234:240	arg1	effects					273:279	diverse biological and pharmacological effects	234:279	diverse biological and pharmacological effects	234:279	Chitosan (CS) possesses diverse biological and pharmacological effects and has been used as a new source of prebiotic.
33191212	1	47	theme	microflora	139:148	arg1	composition					107:117	the composition	103:117	the composition of human intestinal microflora	103:148	Food supplements can modulate the composition of human intestinal microflora due to the potential capacity of improving the host health.
33191212	4	48	theme	CS	600:601	arg1	1g/kg					591:595	1g/kg	591:595	1g/kg of CS	591:601	Mice were divided into 3 groups randomly, and treated with water, 1g/kg of CS, 0.25g/kg of CS, respectively for 24 days.
33191212	4	48	theme	CS	600:601	arg1	water					584:588	water	584:588	water	584:588	Mice were divided into 3 groups randomly, and treated with water, 1g/kg of CS, 0.25g/kg of CS, respectively for 24 days.
33191212	7	49	theme	control	1100:1106	arg1	groups					1133:1138	the control and long-term CS-treated groups	1096:1138	the control and long-term CS-treated groups	1096:1138	ERIC-PCR fingerprint, UPGMA dendrogram, PCA and diversity analysis showed that the intestinal microflora composition was changed with antibiotics treatment, and that samples were significantly separated from those of the control and long-term CS-treated groups.
33191212	7	50	theme	UPGMA	901:905	arg1	dendrogram					907:916	UPGMA dendrogram	901:916	UPGMA dendrogram	901:916	ERIC-PCR fingerprint, UPGMA dendrogram, PCA and diversity analysis showed that the intestinal microflora composition was changed with antibiotics treatment, and that samples were significantly separated from those of the control and long-term CS-treated groups.
33191212	4	51	theme	CS	616:617	arg1	water					584:588	water	584:588	water	584:588	Mice were divided into 3 groups randomly, and treated with water, 1g/kg of CS, 0.25g/kg of CS, respectively for 24 days.
33191212	4	51	theme	CS	616:617	arg1	0.25g/kg					604:611	0.25g/kg	604:611	0.25g/kg of CS	604:617	Mice were divided into 3 groups randomly, and treated with water, 1g/kg of CS, 0.25g/kg of CS, respectively for 24 days.
32825647	4	0	theme	mg/kg	754:758	arg1	mg/kg					768:772	424.6 mg/kg to 39.4 mg/kg	748:772	424.6 mg/kg to 39.4 mg/kg	748:772	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	3	1	theme	@	620:620	arg1	MMT-FeS					621:627	0.5 CMC@MMT-FeS	613:627	0.5 CMC@MMT-FeS	613:627	We tested the efficacy of CMC@MMT-FeS at three concentrations of FeS: 0.2, 0.5, and 1 mmol/g, hereafter referred to as 0.2 CMC@MMT-FeS, 0.5 CMC@MMT-FeS, and 1.0 CMC@MMT-FeS, respectively.
32825647	3	2	theme	@	506:506	arg1	MMT-FeS					507:513	CMC@MMT-FeS	503:513	CMC@MMT-FeS	503:513	We tested the efficacy of CMC@MMT-FeS at three concentrations of FeS: 0.2, 0.5, and 1 mmol/g, hereafter referred to as 0.2 CMC@MMT-FeS, 0.5 CMC@MMT-FeS, and 1.0 CMC@MMT-FeS, respectively.
32825647	6	3	theme	main	1211:1214	arg1	fractions					1219:1227	the main Cr fractions	1207:1227	the main Cr fractions in the soil samples	1207:1247	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	3	4	theme	@	641:641	arg1	MMT-FeS					642:648	1.0 CMC@MMT-FeS	634:648	1.0 CMC@MMT-FeS	634:648	We tested the efficacy of CMC@MMT-FeS at three concentrations of FeS: 0.2, 0.5, and 1 mmol/g, hereafter referred to as 0.2 CMC@MMT-FeS, 0.5 CMC@MMT-FeS, and 1.0 CMC@MMT-FeS, respectively.
32825647	3	5	theme	FeS	542:544	arg1	concentrations					524:537	three concentrations	518:537	three concentrations of FeS	518:544	We tested the efficacy of CMC@MMT-FeS at three concentrations of FeS: 0.2, 0.5, and 1 mmol/g, hereafter referred to as 0.2 CMC@MMT-FeS, 0.5 CMC@MMT-FeS, and 1.0 CMC@MMT-FeS, respectively.
32825647	9	6	dep	Cr	1686:1687	arg1	VI					1689:1690	VI	1689:1690	VI	1689:1690	Our results indicate that CMC@MMT-FeS effectively immobilizes Cr(VI), with widespread potential application in Cr(VI)-contaminated soil remediation.
32825647	4	7	theme	initial	723:729	arg1	concentration					731:743	an initial concentration	720:743	an initial concentration of 424.6 mg/kg to 39.4 mg/kg	720:772	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	5	8	dep	%	1058:1058	arg1	VI					935:936	VI	935:936	VI	935:936	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	5	8	dep	%	1058:1058	arg1	measured					962:969	measured	962:969	measured in the leaching solution using the toxicity characteristic leaching procedure	962:1047	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	6	9	theme	oxidable	1293:1300	arg1	fractions					1302:1310	oxidable fractions	1293:1310	oxidable fractions	1293:1310	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	4	10	dep	decreased	695:703	arg1	VI					677:678	VI	677:678	VI	677:678	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	7	11	theme	photoelectron	1484:1496	arg1	spectroscopy					1498:1509	X-ray photoelectron spectroscopy	1478:1509	X-ray photoelectron spectroscopy	1478:1509	Moreover, the main complex formed during remediation was Fe(III)-Cr(III), based on BCR and X-ray photoelectron spectroscopy analyses.
32825647	1	12	theme	carboxymethyl	215:227	arg1	MMT-FeS					278:284	CMC@MMT-FeS	274:284	CMC@MMT-FeS	274:284	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	1	12	theme	carboxymethyl	215:227	arg1	sulfide					265:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide	189:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS)	189:285	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	7	13	theme	main	1401:1404	arg1	complex					1406:1412	the main complex	1397:1412	the main complex formed during remediation	1397:1438	Moreover, the main complex formed during remediation was Fe(III)-Cr(III), based on BCR and X-ray photoelectron spectroscopy analyses.
32825647	7	13	theme	main	1401:1404	arg1	-Cr					1451:1453	Fe(III)-Cr(III)	1444:1458	Fe(III)-Cr(III)	1444:1458	Moreover, the main complex formed during remediation was Fe(III)-Cr(III), based on BCR and X-ray photoelectron spectroscopy analyses.
32825647	9	14	theme	CMC	1650:1652	arg1	MMT-FeS					1654:1660	CMC@MMT-FeS	1650:1660	CMC@MMT-FeS	1650:1660	Our results indicate that CMC@MMT-FeS effectively immobilizes Cr(VI), with widespread potential application in Cr(VI)-contaminated soil remediation.
32825647	1	15	theme	-contaminated	385:397	arg1	soil					399:402	hexavalent chromium (Cr(VI))-contaminated soil	357:402	hexavalent chromium (Cr(VI))-contaminated soil	357:402	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	1	16	theme	nanoscale	250:258	arg1	MMT-FeS					278:284	CMC@MMT-FeS	274:284	CMC@MMT-FeS	274:284	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	1	16	theme	nanoscale	250:258	arg1	sulfide					265:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide	189:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS)	189:285	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	9	17	dep	Cr	1735:1736	arg1	remediation					1760:1770	-contaminated soil remediation	1741:1770	Cr(VI)-contaminated soil remediation	1735:1770	Our results indicate that CMC@MMT-FeS effectively immobilizes Cr(VI), with widespread potential application in Cr(VI)-contaminated soil remediation.
32825647	9	17	dep	Cr	1735:1736	arg1	VI					1738:1739	VI	1738:1739	VI	1738:1739	Our results indicate that CMC@MMT-FeS effectively immobilizes Cr(VI), with widespread potential application in Cr(VI)-contaminated soil remediation.
32825647	6	18	theme	remediation	1357:1367	arg1	days					1344:1347	30 days	1341:1347	30 days of soil remediation by the composite	1341:1384	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	1	19	theme	sulfide	265:271	arg1	composite					176:184	A novel composite	168:184	A novel composite	168:184	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	1	19	theme	sulfide	265:271	arg1	sulfide					265:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide	189:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS)	189:285	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	4	20	dep	mg/kg	768:772	arg1	to					760:761	to	760:761	to	760:761	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	5	21	theme	0.5	873:875	arg1	%					871:871	%	871:871	%	871:871	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	5	22	theme	@	880:880	arg1	MMT-FeS					881:887	2% 0.5 CMC@MMT-FeS	870:887	2% 0.5 CMC@MMT-FeS	870:887	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	1	23	theme	@	277:277	arg1	MMT-FeS					278:284	CMC@MMT-FeS	274:284	CMC@MMT-FeS	274:284	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	1	23	theme	@	277:277	arg1	sulfide					265:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide	189:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS)	189:285	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	4	24	theme	mass	831:834	arg1	%					813:813	5%	812:813	5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS	812:862	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	4	24	theme	mass	831:834	arg1	proportion					836:845	composite-soil mass proportion	816:845	composite-soil mass proportion	816:845	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	6	25	theme	Community	1151:1159	arg1	test					1187:1190	The European Community Bureau of Reference (BCR) test	1138:1190	The European Community Bureau of Reference (BCR) test	1138:1190	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	1	26	theme	hexavalent	357:366	arg1	Cr					378:379	Cr(VI)	378:383	Cr(VI)	378:383	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	1	26	theme	hexavalent	357:366	arg1	chromium					368:375	hexavalent chromium	357:375	hexavalent chromium (Cr(VI))-contaminated soil	357:402	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	3	27	from	concentrations	524:537	arg1	efficacy					491:498	the efficacy	487:498	the efficacy of CMC@MMT-FeS at three concentrations of FeS	487:544	We tested the efficacy of CMC@MMT-FeS at three concentrations of FeS: 0.2, 0.5, and 1 mmol/g, hereafter referred to as 0.2 CMC@MMT-FeS, 0.5 CMC@MMT-FeS, and 1.0 CMC@MMT-FeS, respectively.
32825647	0	28	theme	Montmorillonite-Supported	41:65	arg1	Composite					115:123	a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite	39:123	a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite	39:123	Immobilization of Cr(VI) in Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite: Effectiveness and Biotoxicity Assessment.
32825647	1	29	theme	novel	170:174	arg1	composite					176:184	A novel composite	168:184	A novel composite	168:184	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	1	29	theme	novel	170:174	arg1	sulfide					265:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide	189:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS)	189:285	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	0	30	from	Immobilization	0:13	arg1	Soil					28:31	Soil	28:31	Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite	28:123	Immobilization of Cr(VI) in Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite: Effectiveness and Biotoxicity Assessment.
32825647	9	31	theme	potential	1710:1718	arg1	application					1720:1730	widespread potential application	1699:1730	widespread potential application in Cr(VI)-contaminated soil remediation	1699:1770	Our results indicate that CMC@MMT-FeS effectively immobilizes Cr(VI), with widespread potential application in Cr(VI)-contaminated soil remediation.
32825647	0	32	theme	Cellulose-Stabilized	81:100	arg1	Composite					115:123	a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite	39:123	a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite	39:123	Immobilization of Cr(VI) in Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite: Effectiveness and Biotoxicity Assessment.
32825647	8	33	theme	soils	1551:1555	arg1	Biotoxicity					1521:1531	Biotoxicity	1521:1531	Biotoxicity	1521:1531	Biotoxicity of the remediated soils, using Vicia faba and Eisenia foetida, was analyzed and evaluated.
32825647	5	34	theme	hazardous	1111:1119	arg1	waste					1121:1125	hazardous waste	1111:1125	hazardous waste (5 mg/kg)	1111:1135	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	5	34	theme	hazardous	1111:1119	arg1	mg/kg					1130:1134	5 mg/kg	1128:1134	5 mg/kg	1128:1134	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	0	35	theme	Sulfide	107:113	arg1	Composite					115:123	a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite	39:123	a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite	39:123	Immobilization of Cr(VI) in Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite: Effectiveness and Biotoxicity Assessment.
32825647	9	36	theme	soil	1755:1758	arg1	remediation					1760:1770	-contaminated soil remediation	1741:1770	Cr(VI)-contaminated soil remediation	1735:1770	Our results indicate that CMC@MMT-FeS effectively immobilizes Cr(VI), with widespread potential application in Cr(VI)-contaminated soil remediation.
32825647	1	37	dep	Cr	378:379	arg1	VI					381:382	VI	381:382	VI	381:382	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	5	38	theme	environmental	1073:1085	arg1	protection					1087:1096	the environmental protection	1069:1096	the environmental protection standard for hazardous waste (5 mg/kg)	1069:1135	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	2	39	theme	-removal	411:418	arg1	capacity					420:427	-removal capacity	411:427	-removal capacity	411:427	Cr(VI)-removal capacity increased with increasing FeS-particle loading.
32825647	0	40	theme	Cr	18:19	arg1	Immobilization					0:13	Immobilization	0:13	Immobilization of Cr(VI) in Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite: Effectiveness and Biotoxicity Assessment.	0:166	Immobilization of Cr(VI) in Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite: Effectiveness and Biotoxicity Assessment.
32825647	4	41	theme	CMC	852:854	arg1	MMT-FeS					856:862	5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS	812:862	5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS	812:862	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	3	42	theme	@	603:603	arg1	MMT-FeS					604:610	as 0.2 CMC@MMT-FeS	593:610	as 0.2 CMC@MMT-FeS	593:610	We tested the efficacy of CMC@MMT-FeS at three concentrations of FeS: 0.2, 0.5, and 1 mmol/g, hereafter referred to as 0.2 CMC@MMT-FeS, 0.5 CMC@MMT-FeS, and 1.0 CMC@MMT-FeS, respectively.
32825647	5	43	theme	standard	1098:1105	arg1	protection					1087:1096	the environmental protection	1069:1096	the environmental protection standard for hazardous waste (5 mg/kg)	1069:1135	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	4	44	theme	MMT-FeS	856:862	arg1	addition					800:807	addition	800:807	addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS	800:862	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	6	45	theme	of	1168:1169	arg1	test					1187:1190	The European Community Bureau of Reference (BCR) test	1138:1190	The European Community Bureau of Reference (BCR) test	1138:1190	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	3	46	theme	CMC	617:619	arg1	MMT-FeS					621:627	0.5 CMC@MMT-FeS	613:627	0.5 CMC@MMT-FeS	613:627	We tested the efficacy of CMC@MMT-FeS at three concentrations of FeS: 0.2, 0.5, and 1 mmol/g, hereafter referred to as 0.2 CMC@MMT-FeS, 0.5 CMC@MMT-FeS, and 1.0 CMC@MMT-FeS, respectively.
32825647	6	47	theme	soil	1236:1239	arg1	samples					1241:1247	the soil samples	1232:1247	the soil samples	1232:1247	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	0	48	dep	Cr	18:19	arg1	VI					21:22	VI	21:22	VI	21:22	Immobilization of Cr(VI) in Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite: Effectiveness and Biotoxicity Assessment.
32825647	5	49	dep	Cr	902:903	arg1	VI					905:906	VI	905:906	VI	905:906	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	5	49	dep	Cr	902:903	arg1	soil					922:925	-contaminated soil	908:925	Cr(VI)-contaminated soil	902:925	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	3	50	theme	MMT-FeS	507:513	arg1	efficacy					491:498	the efficacy	487:498	the efficacy of CMC@MMT-FeS at three concentrations of FeS	487:544	We tested the efficacy of CMC@MMT-FeS at three concentrations of FeS: 0.2, 0.5, and 1 mmol/g, hereafter referred to as 0.2 CMC@MMT-FeS, 0.5 CMC@MMT-FeS, and 1.0 CMC@MMT-FeS, respectively.
32825647	5	51	theme	toxicity	1006:1013	arg1	procedure					1039:1047	the toxicity characteristic leaching procedure	1002:1047	the toxicity characteristic leaching procedure	1002:1047	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	0	52	dep	Immobilization	0:13	arg1	Effectiveness					126:138	Effectiveness	126:138	Effectiveness	126:138	Immobilization of Cr(VI) in Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite: Effectiveness and Biotoxicity Assessment.
32825647	0	52	dep	Immobilization	0:13	arg1	Assessment					156:165	Biotoxicity Assessment	144:165	Biotoxicity Assessment	144:165	Immobilization of Cr(VI) in Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite: Effectiveness and Biotoxicity Assessment.
32825647	6	53	theme	European	1142:1149	arg1	test					1187:1190	The European Community Bureau of Reference (BCR) test	1138:1190	The European Community Bureau of Reference (BCR) test	1138:1190	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	8	54	theme	Eisenia	1579:1585	arg1	foetida					1587:1593	Eisenia foetida	1579:1593	Eisenia foetida	1579:1593	Biotoxicity of the remediated soils, using Vicia faba and Eisenia foetida, was analyzed and evaluated.
32825647	3	55	theme	CMC	503:505	arg1	MMT-FeS					507:513	CMC@MMT-FeS	503:513	CMC@MMT-FeS	503:513	We tested the efficacy of CMC@MMT-FeS at three concentrations of FeS: 0.2, 0.5, and 1 mmol/g, hereafter referred to as 0.2 CMC@MMT-FeS, 0.5 CMC@MMT-FeS, and 1.0 CMC@MMT-FeS, respectively.
32825647	6	56	theme	Cr	1216:1217	arg1	fractions					1219:1227	the main Cr fractions	1207:1227	the main Cr fractions in the soil samples	1207:1247	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	3	57	dep	MMT-FeS	604:610	arg1	CMC					600:602	CMC	600:602	CMC	600:602	We tested the efficacy of CMC@MMT-FeS at three concentrations of FeS: 0.2, 0.5, and 1 mmol/g, hereafter referred to as 0.2 CMC@MMT-FeS, 0.5 CMC@MMT-FeS, and 1.0 CMC@MMT-FeS, respectively.
32825647	5	58	theme	leaching	978:985	arg1	solution					987:994	the leaching solution	974:994	the leaching solution using the toxicity characteristic leaching procedure	974:1047	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	7	59	theme	spectroscopy	1498:1509	arg1	analyses					1511:1518	BCR and X-ray photoelectron spectroscopy analyses	1470:1518	BCR and X-ray photoelectron spectroscopy analyses	1470:1518	Moreover, the main complex formed during remediation was Fe(III)-Cr(III), based on BCR and X-ray photoelectron spectroscopy analyses.
32825647	2	60	theme	FeS-particle	455:466	arg1	loading					468:474	FeS-particle loading	455:474	FeS-particle loading	455:474	Cr(VI)-removal capacity increased with increasing FeS-particle loading.
32825647	7	61	theme	X-ray	1478:1482	arg1	spectroscopy					1498:1509	X-ray photoelectron spectroscopy	1478:1509	X-ray photoelectron spectroscopy	1478:1509	Moreover, the main complex formed during remediation was Fe(III)-Cr(III), based on BCR and X-ray photoelectron spectroscopy analyses.
32825647	3	62	theme	CMC	638:640	arg1	MMT-FeS					642:648	1.0 CMC@MMT-FeS	634:648	1.0 CMC@MMT-FeS	634:648	We tested the efficacy of CMC@MMT-FeS at three concentrations of FeS: 0.2, 0.5, and 1 mmol/g, hereafter referred to as 0.2 CMC@MMT-FeS, 0.5 CMC@MMT-FeS, and 1.0 CMC@MMT-FeS, respectively.
32825647	1	63	theme	montmorillonite-supported	189:213	arg1	MMT-FeS					278:284	CMC@MMT-FeS	274:284	CMC@MMT-FeS	274:284	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	1	63	theme	montmorillonite-supported	189:213	arg1	sulfide					265:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide	189:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS)	189:285	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	7	64	theme	BCR	1470:1472	arg1	analyses					1511:1518	BCR and X-ray photoelectron spectroscopy analyses	1470:1518	BCR and X-ray photoelectron spectroscopy analyses	1470:1518	Moreover, the main complex formed during remediation was Fe(III)-Cr(III), based on BCR and X-ray photoelectron spectroscopy analyses.
32825647	6	65	theme	acid-exchangeable	1262:1278	arg1	fractions					1280:1288	acid-exchangeable fractions	1262:1288	acid-exchangeable fractions	1262:1288	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	1	66	theme	cellulose-stabilized	229:248	arg1	MMT-FeS					278:284	CMC@MMT-FeS	274:284	CMC@MMT-FeS	274:284	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	1	66	theme	cellulose-stabilized	229:248	arg1	sulfide					265:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide	189:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS)	189:285	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	9	67	theme	@	1653:1653	arg1	MMT-FeS					1654:1660	CMC@MMT-FeS	1650:1660	CMC@MMT-FeS	1650:1660	Our results indicate that CMC@MMT-FeS effectively immobilizes Cr(VI), with widespread potential application in Cr(VI)-contaminated soil remediation.
32825647	0	68	theme	Biotoxicity	144:154	arg1	Assessment					156:165	Biotoxicity Assessment	144:165	Biotoxicity Assessment	144:165	Immobilization of Cr(VI) in Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite: Effectiveness and Biotoxicity Assessment.
32825647	1	69	theme	iron	260:263	arg1	MMT-FeS					278:284	CMC@MMT-FeS	274:284	CMC@MMT-FeS	274:284	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	1	69	theme	iron	260:263	arg1	sulfide					265:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide	189:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS)	189:285	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	6	70	theme	soil	1352:1355	arg1	remediation					1357:1367	soil remediation	1352:1367	soil remediation by the composite	1352:1384	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	4	71	theme	mg/kg	768:772	arg1	concentration					731:743	an initial concentration	720:743	an initial concentration of 424.6 mg/kg to 39.4 mg/kg	720:772	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	5	72	theme	CMC	877:879	arg1	MMT-FeS					881:887	2% 0.5 CMC@MMT-FeS	870:887	2% 0.5 CMC@MMT-FeS	870:887	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	6	73	theme	Bureau	1161:1166	arg1	test					1187:1190	The European Community Bureau of Reference (BCR) test	1138:1190	The European Community Bureau of Reference (BCR) test	1138:1190	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	4	74	theme	composite-soil	816:829	arg1	%					813:813	5%	812:813	5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS	812:862	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	4	74	theme	composite-soil	816:829	arg1	proportion					836:845	composite-soil mass proportion	816:845	composite-soil mass proportion	816:845	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	5	75	theme	leaching	1030:1037	arg1	procedure					1039:1047	the toxicity characteristic leaching procedure	1002:1047	the toxicity characteristic leaching procedure	1002:1047	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	0	76	theme	Carboxymethyl	67:79	arg1	Composite					115:123	a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite	39:123	a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite	39:123	Immobilization of Cr(VI) in Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite: Effectiveness and Biotoxicity Assessment.
32825647	1	77	theme	chromium	368:375	arg1	soil					399:402	hexavalent chromium (Cr(VI))-contaminated soil	357:402	hexavalent chromium (Cr(VI))-contaminated soil	357:402	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	6	78	theme	residual	1316:1323	arg1	fractions					1325:1333	residual fractions	1316:1333	residual fractions	1316:1333	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	9	79	theme	widespread	1699:1708	arg1	application					1720:1730	widespread potential application	1699:1730	widespread potential application in Cr(VI)-contaminated soil remediation	1699:1770	Our results indicate that CMC@MMT-FeS effectively immobilizes Cr(VI), with widespread potential application in Cr(VI)-contaminated soil remediation.
32825647	0	80	theme	Iron	102:105	arg1	Composite					115:123	a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite	39:123	a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite	39:123	Immobilization of Cr(VI) in Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite: Effectiveness and Biotoxicity Assessment.
32825647	4	81	theme	soil	669:672	arg1	Cr					674:675	The soil Cr	665:675	The soil Cr	665:675	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	4	82	from	concentration	731:743	arg1	%					712:712	90.7%	708:712	90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg)	708:773	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	2	83	dep	increased	429:437	arg1	VI					408:409	VI	408:409	VI	408:409	Cr(VI)-removal capacity increased with increasing FeS-particle loading.
32825647	8	84	theme	remediated	1540:1549	arg1	soils					1551:1555	the remediated soils	1536:1555	the remediated soils	1536:1555	Biotoxicity of the remediated soils, using Vicia faba and Eisenia foetida, was analyzed and evaluated.
32825647	4	85	theme	%	813:813	arg1	MMT-FeS					856:862	5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS	812:862	5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS	812:862	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	5	86	theme	-contaminated	908:920	arg1	soil					922:925	-contaminated soil	908:925	Cr(VI)-contaminated soil	902:925	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	7	87	theme	Fe	1444:1445	arg1	complex					1406:1412	the main complex	1397:1412	the main complex formed during remediation	1397:1438	Moreover, the main complex formed during remediation was Fe(III)-Cr(III), based on BCR and X-ray photoelectron spectroscopy analyses.
32825647	7	87	theme	Fe	1444:1445	arg1	-Cr					1451:1453	Fe(III)-Cr(III)	1444:1458	Fe(III)-Cr(III)	1444:1458	Moreover, the main complex formed during remediation was Fe(III)-Cr(III), based on BCR and X-ray photoelectron spectroscopy analyses.
32825647	1	88	theme	co-precipitation	307:322	arg1	method					324:329	the co-precipitation method	303:329	the co-precipitation method	303:329	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	8	89	theme	Vicia	1564:1568	arg1	faba					1570:1573	Vicia faba	1564:1573	Vicia faba	1564:1573	Biotoxicity of the remediated soils, using Vicia faba and Eisenia foetida, was analyzed and evaluated.
32825647	9	90	theme	-contaminated	1741:1753	arg1	remediation					1760:1770	-contaminated soil remediation	1741:1770	Cr(VI)-contaminated soil remediation	1735:1770	Our results indicate that CMC@MMT-FeS effectively immobilizes Cr(VI), with widespread potential application in Cr(VI)-contaminated soil remediation.
32825647	6	91	theme	BCR	1182:1184	arg1	test					1187:1190	The European Community Bureau of Reference (BCR) test	1138:1190	The European Community Bureau of Reference (BCR) test	1138:1190	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	3	92	dep	CMC	600:602	arg1	0.2					596:598	0.2	596:598	0.2	596:598	We tested the efficacy of CMC@MMT-FeS at three concentrations of FeS: 0.2, 0.5, and 1 mmol/g, hereafter referred to as 0.2 CMC@MMT-FeS, 0.5 CMC@MMT-FeS, and 1.0 CMC@MMT-FeS, respectively.
32825647	6	93	theme	Reference	1171:1179	arg1	test					1187:1190	The European Community Bureau of Reference (BCR) test	1138:1190	The European Community Bureau of Reference (BCR) test	1138:1190	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	5	94	theme	2	870:870	arg1	%					871:871	%	871:871	%	871:871	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	4	95	theme	@	855:855	arg1	MMT-FeS					856:862	5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS	812:862	5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS	812:862	The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 mg/kg to 39.4 mg/kg) after 30 days, following addition of 5% (composite-soil mass proportion) 1.0 CMC@MMT-FeS.
32825647	5	96	theme	removal	939:945	arg1	efficiency					947:956	removal efficiency	939:956	removal efficiency	939:956	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
32825647	1	97	theme	CMC	274:276	arg1	MMT-FeS					278:284	CMC@MMT-FeS	274:284	CMC@MMT-FeS	274:284	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	1	97	theme	CMC	274:276	arg1	sulfide					265:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide	189:271	montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS)	189:285	A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil.
32825647	6	98	from	fractions	1219:1227	arg1	samples					1241:1247	the soil samples	1232:1247	the soil samples	1232:1247	The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite.
32825647	9	99	from	application	1720:1730	arg1	Cr					1735:1736	Cr(VI)-contaminated soil remediation	1735:1770	Cr(VI)-contaminated soil remediation	1735:1770	Our results indicate that CMC@MMT-FeS effectively immobilizes Cr(VI), with widespread potential application in Cr(VI)-contaminated soil remediation.
32825647	5	100	theme	characteristic	1015:1028	arg1	procedure					1039:1047	the toxicity characteristic leaching procedure	1002:1047	the toxicity characteristic leaching procedure	1002:1047	When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg).
33766362	0	0	theme	wound	117:121	arg1	dressing					123:130	wound dressing	117:130	wound dressing	117:130	Preparation and properties of polyvinyl alcohol/N-succinyl chitosan/lincomycin composite antibacterial hydrogels for wound dressing.
33766362	1	1	theme	large	205:209	arg1	water					222:226	water	222:226	water	222:226	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	1	1	theme	large	205:209	arg1	fluids					242:247	biological fluids	231:247	biological fluids	231:247	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	1	1	theme	large	205:209	arg1	amounts					211:217	large amounts	205:217	large amounts of water or biological fluids	205:247	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	5	2	theme	remarkable	950:959	arg1	activity					975:982	a remarkable antibacterial activity	948:982	a remarkable antibacterial activity against both Escherichia coli and Staphylococcus aureus	948:1038	The optimal compression strength of 0.75 MPa was achieved with 30 % NSCS content.Additionally, the incorporation of lincomycin brought a remarkable antibacterial activity against both Escherichia coli and Staphylococcus aureus.
33766362	5	3	theme	lincomycin	929:938	arg1	incorporation					912:924	the incorporation	908:924	the incorporation of lincomycin	908:938	The optimal compression strength of 0.75 MPa was achieved with 30 % NSCS content.Additionally, the incorporation of lincomycin brought a remarkable antibacterial activity against both Escherichia coli and Staphylococcus aureus.
33766362	2	4	theme	wound	388:392	arg1	dressing					394:401	wound dressing	388:401	wound dressing	388:401	Herein, polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing were prepared by the freezing/thawing method, then characterized by FTIR, SEM, and TGA.
33766362	7	5	theme	promising	1262:1270	arg1	potential					1272:1280	promising potential	1262:1280	promising potential for wound dressing	1262:1299	In summary, this PVA/NSCS/lincomycin hydrogel showed promising potential for wound dressing.
33766362	4	6	from	water	806:810	arg1	ratio					774:778	the maximum swelling ratio	753:778	the maximum swelling ratio of 19.68 g/g in deionized water	753:810	The results showed that the introduction of NSCS remarkably enhanced the swelling capacity, leading to the maximum swelling ratio of 19.68 g/g in deionized water.
33766362	3	7	theme	antibacterial	562:574	arg1	activity					576:583	antibacterial activity	562:583	antibacterial activity	562:583	The compression strength, swelling behavior, water retention capacity, antibacterial activity, drug release and cytotoxicity were systematically investigated.
33766362	3	8	theme	drug	586:589	arg1	release					591:597	drug release	586:597	drug release	586:597	The compression strength, swelling behavior, water retention capacity, antibacterial activity, drug release and cytotoxicity were systematically investigated.
33766362	4	9	theme	swelling	765:772	arg1	ratio					774:778	the maximum swelling ratio	753:778	the maximum swelling ratio of 19.68 g/g in deionized water	753:810	The results showed that the introduction of NSCS remarkably enhanced the swelling capacity, leading to the maximum swelling ratio of 19.68 g/g in deionized water.
33766362	4	10	theme	maximum	757:763	arg1	ratio					774:778	the maximum swelling ratio	753:778	the maximum swelling ratio of 19.68 g/g in deionized water	753:810	The results showed that the introduction of NSCS remarkably enhanced the swelling capacity, leading to the maximum swelling ratio of 19.68 g/g in deionized water.
33766362	5	11	theme	antibacterial	961:973	arg1	activity					975:982	a remarkable antibacterial activity	948:982	a remarkable antibacterial activity against both Escherichia coli and Staphylococcus aureus	948:1038	The optimal compression strength of 0.75 MPa was achieved with 30 % NSCS content.Additionally, the incorporation of lincomycin brought a remarkable antibacterial activity against both Escherichia coli and Staphylococcus aureus.
33766362	4	12	from	g/g	789:791	arg1	water					806:810	deionized water	796:810	deionized water	796:810	The results showed that the introduction of NSCS remarkably enhanced the swelling capacity, leading to the maximum swelling ratio of 19.68 g/g in deionized water.
33766362	2	13	theme	alcohol	322:328	arg1	hydrogels					374:382	polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels	312:382	polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing	312:401	Herein, polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing were prepared by the freezing/thawing method, then characterized by FTIR, SEM, and TGA.
33766362	6	14	theme	MTT	1138:1140	arg1	assay					1142:1146	the MTT assay	1134:1146	the MTT assay	1134:1146	Specifically, 77.71 % of Staphylococcus aureus was inhibited with 75 μg/mL lincomycin, while the MTT assay demonstrated the nontoxic nature of the composite hydrogels.
33766362	1	15	theme	water	222:226	arg1	water					222:226	water	222:226	water	222:226	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	1	15	theme	water	222:226	arg1	fluids					242:247	biological fluids	231:247	biological fluids	231:247	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	1	15	theme	water	222:226	arg1	amounts					211:217	large amounts	205:217	large amounts of water or biological fluids	205:247	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	7	16	theme	wound	1286:1290	arg1	dressing					1292:1299	wound dressing	1286:1299	wound dressing	1286:1299	In summary, this PVA/NSCS/lincomycin hydrogel showed promising potential for wound dressing.
33766362	4	17	theme	NSCS	694:697	arg1	introduction					678:689	the introduction	674:689	the introduction of NSCS	674:697	The results showed that the introduction of NSCS remarkably enhanced the swelling capacity, leading to the maximum swelling ratio of 19.68 g/g in deionized water.
33766362	2	18	theme	NSCS	357:360	arg1	hydrogels					374:382	polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels	312:382	polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing	312:401	Herein, polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing were prepared by the freezing/thawing method, then characterized by FTIR, SEM, and TGA.
33766362	6	19	theme	aureus	1081:1086	arg1	%					1061:1061	77.71 %	1055:1061	77.71 % of Staphylococcus aureus	1055:1086	Specifically, 77.71 % of Staphylococcus aureus was inhibited with 75 μg/mL lincomycin, while the MTT assay demonstrated the nontoxic nature of the composite hydrogels.
33766362	6	19	theme	aureus	1081:1086	arg1	aureus					1081:1086	Staphylococcus aureus	1066:1086	Staphylococcus aureus	1066:1086	Specifically, 77.71 % of Staphylococcus aureus was inhibited with 75 μg/mL lincomycin, while the MTT assay demonstrated the nontoxic nature of the composite hydrogels.
33766362	1	20	theme	biological	231:240	arg1	fluids					242:247	biological fluids	231:247	biological fluids	231:247	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	5	21	theme	MPa	854:856	arg1	strength					837:844	The optimal compression strength	813:844	The optimal compression strength of 0.75 MPa	813:856	The optimal compression strength of 0.75 MPa was achieved with 30 % NSCS content.Additionally, the incorporation of lincomycin brought a remarkable antibacterial activity against both Escherichia coli and Staphylococcus aureus.
33766362	4	22	from	ratio	774:778	arg1	water					806:810	deionized water	796:810	deionized water	796:810	The results showed that the introduction of NSCS remarkably enhanced the swelling capacity, leading to the maximum swelling ratio of 19.68 g/g in deionized water.
33766362	2	23	theme	chitosan	347:354	arg1	hydrogels					374:382	polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels	312:382	polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing	312:401	Herein, polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing were prepared by the freezing/thawing method, then characterized by FTIR, SEM, and TGA.
33766362	1	24	theme	fluids	242:247	arg1	water					222:226	water	222:226	water	222:226	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	1	24	theme	fluids	242:247	arg1	fluids					242:247	biological fluids	231:247	biological fluids	231:247	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	1	24	theme	fluids	242:247	arg1	amounts					211:217	large amounts	205:217	large amounts of water or biological fluids	205:247	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	6	25	theme	nontoxic	1165:1172	arg1	nature					1174:1179	the nontoxic nature	1161:1179	the nontoxic nature of the composite hydrogels	1161:1206	Specifically, 77.71 % of Staphylococcus aureus was inhibited with 75 μg/mL lincomycin, while the MTT assay demonstrated the nontoxic nature of the composite hydrogels.
33766362	2	26	theme	/N-succinyl	335:345	arg1	hydrogels					374:382	polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels	312:382	polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing	312:401	Herein, polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing were prepared by the freezing/thawing method, then characterized by FTIR, SEM, and TGA.
33766362	0	27	theme	alcohol/N-succinyl	40:57	arg1	properties					16:25	properties	16:25	properties	16:25	Preparation and properties of polyvinyl alcohol/N-succinyl chitosan/lincomycin composite antibacterial hydrogels for wound dressing.
33766362	0	27	theme	alcohol/N-succinyl	40:57	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and properties of polyvinyl alcohol/N-succinyl chitosan/lincomycin composite antibacterial hydrogels for wound dressing.
33766362	3	28	theme	swelling	517:524	arg1	behavior					526:533	swelling behavior	517:533	swelling behavior	517:533	The compression strength, swelling behavior, water retention capacity, antibacterial activity, drug release and cytotoxicity were systematically investigated.
33766362	7	29	theme	PVA/NSCS/lincomycin	1226:1244	arg1	hydrogel					1246:1253	this PVA/NSCS/lincomycin hydrogel	1221:1253	this PVA/NSCS/lincomycin hydrogel	1221:1253	In summary, this PVA/NSCS/lincomycin hydrogel showed promising potential for wound dressing.
33766362	5	30	theme	30	876:877	arg1	%					879:879	%	879:879	%	879:879	The optimal compression strength of 0.75 MPa was achieved with 30 % NSCS content.Additionally, the incorporation of lincomycin brought a remarkable antibacterial activity against both Escherichia coli and Staphylococcus aureus.
33766362	0	31	theme	polyvinyl	30:38	arg1	alcohol/N-succinyl					40:57	polyvinyl alcohol/N-succinyl	30:57	polyvinyl alcohol/N-succinyl	30:57	Preparation and properties of polyvinyl alcohol/N-succinyl chitosan/lincomycin composite antibacterial hydrogels for wound dressing.
33766362	5	32	theme	optimal	817:823	arg1	strength					837:844	The optimal compression strength	813:844	The optimal compression strength of 0.75 MPa	813:856	The optimal compression strength of 0.75 MPa was achieved with 30 % NSCS content.Additionally, the incorporation of lincomycin brought a remarkable antibacterial activity against both Escherichia coli and Staphylococcus aureus.
33766362	5	33	theme	%	879:879	arg1	NSCS					881:884	30 % NSCS	876:884	30 % NSCS	876:884	The optimal compression strength of 0.75 MPa was achieved with 30 % NSCS content.Additionally, the incorporation of lincomycin brought a remarkable antibacterial activity against both Escherichia coli and Staphylococcus aureus.
33766362	0	34	theme	composite	79:87	arg1	hydrogels					103:111	composite antibacterial hydrogels	79:111	composite antibacterial hydrogels for wound dressing	79:130	Preparation and properties of polyvinyl alcohol/N-succinyl chitosan/lincomycin composite antibacterial hydrogels for wound dressing.
33766362	1	35	theme	three-dimensional	147:163	arg1	networks					175:182	three-dimensional polymeric networks	147:182	three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues	147:301	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	1	35	theme	three-dimensional	147:163	arg1	Hydrogels					133:141	Hydrogels	133:141	Hydrogels	133:141	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	3	36	theme	compression	495:505	arg1	strength					507:514	The compression strength	491:514	The compression strength	491:514	The compression strength, swelling behavior, water retention capacity, antibacterial activity, drug release and cytotoxicity were systematically investigated.
33766362	6	37	theme	hydrogels	1198:1206	arg1	nature					1174:1179	the nontoxic nature	1161:1179	the nontoxic nature of the composite hydrogels	1161:1206	Specifically, 77.71 % of Staphylococcus aureus was inhibited with 75 μg/mL lincomycin, while the MTT assay demonstrated the nontoxic nature of the composite hydrogels.
33766362	1	38	theme	polymeric	165:173	arg1	networks					175:182	three-dimensional polymeric networks	147:182	three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues	147:301	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	1	38	theme	polymeric	165:173	arg1	Hydrogels					133:141	Hydrogels	133:141	Hydrogels	133:141	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	5	39	theme	compression	825:835	arg1	strength					837:844	The optimal compression strength	813:844	The optimal compression strength of 0.75 MPa	813:856	The optimal compression strength of 0.75 MPa was achieved with 30 % NSCS content.Additionally, the incorporation of lincomycin brought a remarkable antibacterial activity against both Escherichia coli and Staphylococcus aureus.
33766362	2	40	theme	polyvinyl	312:320	arg1	PVA					331:333	PVA	331:333	PVA	331:333	Herein, polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing were prepared by the freezing/thawing method, then characterized by FTIR, SEM, and TGA.
33766362	2	40	theme	polyvinyl	312:320	arg1	alcohol					322:328	polyvinyl alcohol	312:328	polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing	312:401	Herein, polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing were prepared by the freezing/thawing method, then characterized by FTIR, SEM, and TGA.
33766362	4	41	theme	swelling	723:730	arg1	capacity					732:739	the swelling capacity	719:739	the swelling capacity	719:739	The results showed that the introduction of NSCS remarkably enhanced the swelling capacity, leading to the maximum swelling ratio of 19.68 g/g in deionized water.
33766362	2	42	theme	/lincomycin	362:372	arg1	hydrogels					374:382	polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels	312:382	polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing	312:401	Herein, polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing were prepared by the freezing/thawing method, then characterized by FTIR, SEM, and TGA.
33766362	4	43	theme	g/g	789:791	arg1	ratio					774:778	the maximum swelling ratio	753:778	the maximum swelling ratio of 19.68 g/g in deionized water	753:810	The results showed that the introduction of NSCS remarkably enhanced the swelling capacity, leading to the maximum swelling ratio of 19.68 g/g in deionized water.
33766362	4	44	theme	deionized	796:804	arg1	water					806:810	deionized water	796:810	deionized water	796:810	The results showed that the introduction of NSCS remarkably enhanced the swelling capacity, leading to the maximum swelling ratio of 19.68 g/g in deionized water.
33766362	1	45	theme	capable	184:190	arg1	networks					175:182	three-dimensional polymeric networks	147:182	three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues	147:301	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	1	45	theme	capable	184:190	arg1	Hydrogels					133:141	Hydrogels	133:141	Hydrogels	133:141	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	1	46	theme	natural	280:286	arg1	tissues					295:301	natural living tissues	280:301	natural living tissues	280:301	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	6	47	theme	μg/mL	1110:1114	arg1	lincomycin					1116:1125	75 μg/mL lincomycin	1107:1125	75 μg/mL lincomycin	1107:1125	Specifically, 77.71 % of Staphylococcus aureus was inhibited with 75 μg/mL lincomycin, while the MTT assay demonstrated the nontoxic nature of the composite hydrogels.
33766362	3	48	theme	water	536:540	arg1	capacity					552:559	water retention capacity	536:559	water retention capacity	536:559	The compression strength, swelling behavior, water retention capacity, antibacterial activity, drug release and cytotoxicity were systematically investigated.
33766362	2	49	theme	freezing/thawing	424:439	arg1	method					441:446	the freezing/thawing method	420:446	the freezing/thawing method	420:446	Herein, polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing were prepared by the freezing/thawing method, then characterized by FTIR, SEM, and TGA.
33766362	1	50	theme	living	288:293	arg1	tissues					295:301	natural living tissues	280:301	natural living tissues	280:301	Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues.
33766362	0	51	theme	antibacterial	89:101	arg1	hydrogels					103:111	composite antibacterial hydrogels	79:111	composite antibacterial hydrogels for wound dressing	79:130	Preparation and properties of polyvinyl alcohol/N-succinyl chitosan/lincomycin composite antibacterial hydrogels for wound dressing.
33766362	6	52	theme	composite	1188:1196	arg1	hydrogels					1198:1206	the composite hydrogels	1184:1206	the composite hydrogels	1184:1206	Specifically, 77.71 % of Staphylococcus aureus was inhibited with 75 μg/mL lincomycin, while the MTT assay demonstrated the nontoxic nature of the composite hydrogels.
33766362	3	53	theme	retention	542:550	arg1	capacity					552:559	water retention capacity	536:559	water retention capacity	536:559	The compression strength, swelling behavior, water retention capacity, antibacterial activity, drug release and cytotoxicity were systematically investigated.
33199119	0	0	theme	-inhibiting	80:90	arg1	rice					123:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	Compositional differences in hybrids between protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice and weedy rice accessions.
33199119	5	1	theme	F2	858:859	arg1	progeny					861:867	the F2 progeny	854:867	the F2 progeny	854:867	However, levels of galactopyranose, trehalose, xylofuranose, mannitol, and benzoic acid were higher in the F2 progeny.
33199119	3	2	theme	progeny	544:550	arg1	profiles					529:536	the metabolite profiles	514:536	the metabolite profiles of F2 progeny	514:550	Although the metabolite profiles of F2 progeny were partially separated from their parents, zygosity did not affect the profiles.
33199119	5	3	theme	mannitol	812:819	arg1	levels					760:765	levels	760:765	levels of galactopyranose, trehalose, xylofuranose, mannitol, and benzoic acid	760:837	However, levels of galactopyranose, trehalose, xylofuranose, mannitol, and benzoic acid were higher in the F2 progeny.
33199119	0	4	from	differences	14:24	arg1	hybrids					29:35	hybrids	29:35	hybrids	29:35	Compositional differences in hybrids between protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice and weedy rice accessions.
33199119	0	5	theme	transgenic	112:121	arg1	rice					123:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	Compositional differences in hybrids between protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice and weedy rice accessions.
33199119	6	6	theme	quantitative	927:938	arg1	differences					940:950	prominent quantitative differences	917:950	prominent quantitative differences between the F2 progeny and the parents	917:989	Some fatty acids and organic acids also showed prominent quantitative differences between the F2 progeny and the parents.
33199119	7	7	theme	hybrids	1143:1149	arg1	quality					1177:1183	the nutritional quality	1161:1183	the nutritional quality	1161:1183	Changes in the metabolite levels of transgenic crop-weed hybrids compared to their parents might influence not only the ecological consequences of the hybrids, but also the nutritional quality and food safety.
33199119	7	7	theme	hybrids	1143:1149	arg1	safety					1194:1199	food safety	1189:1199	food safety	1189:1199	Changes in the metabolite levels of transgenic crop-weed hybrids compared to their parents might influence not only the ecological consequences of the hybrids, but also the nutritional quality and food safety.
33199119	7	7	theme	hybrids	1143:1149	arg1	consequences					1123:1134	the ecological consequences	1108:1134	the ecological consequences of the hybrids	1108:1149	Changes in the metabolite levels of transgenic crop-weed hybrids compared to their parents might influence not only the ecological consequences of the hybrids, but also the nutritional quality and food safety.
33199119	1	8	from	metabolites	176:186	arg1	grains					191:196	grains	191:196	grains	191:196	We characterized the metabolites in grains of transgenic protoporphyrinogen IX oxidase-inhibiting herbicide-resistant rice and weedy accessions using GC-MS and examined whether the chemical composition of their hybrids differed from that of the parents.
33199119	7	9	theme	metabolite	1007:1016	arg1	levels					1018:1023	the metabolite levels	1003:1023	the metabolite levels of transgenic crop-weed hybrids	1003:1055	Changes in the metabolite levels of transgenic crop-weed hybrids compared to their parents might influence not only the ecological consequences of the hybrids, but also the nutritional quality and food safety.
33199119	0	10	theme	herbicide-resistant	92:110	arg1	rice					123:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	Compositional differences in hybrids between protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice and weedy rice accessions.
33199119	6	11	theme	prominent	917:925	arg1	differences					940:950	prominent quantitative differences	917:950	prominent quantitative differences between the F2 progeny and the parents	917:989	Some fatty acids and organic acids also showed prominent quantitative differences between the F2 progeny and the parents.
33199119	7	12	from	Changes	992:998	arg1	levels					1018:1023	the metabolite levels	1003:1023	the metabolite levels of transgenic crop-weed hybrids	1003:1055	Changes in the metabolite levels of transgenic crop-weed hybrids compared to their parents might influence not only the ecological consequences of the hybrids, but also the nutritional quality and food safety.
33199119	2	13	theme	rice	461:464	arg1	profiles					438:445	the metabolite profiles	423:445	the metabolite profiles of transgenic rice and weedy rice	423:479	We found that the metabolite profiles of transgenic rice and weedy rice were clearly separated.
33199119	4	14	theme	major	693:697	arg1	components					711:720	most major nutritional components	688:720	most major nutritional components	688:720	The F2 progeny had similar or intermediate levels of most major nutritional components compared with their parents.
33199119	5	15	theme	trehalose	787:795	arg1	levels					760:765	levels	760:765	levels of galactopyranose, trehalose, xylofuranose, mannitol, and benzoic acid	760:837	However, levels of galactopyranose, trehalose, xylofuranose, mannitol, and benzoic acid were higher in the F2 progeny.
33199119	2	16	theme	metabolite	427:436	arg1	profiles					438:445	the metabolite profiles	423:445	the metabolite profiles of transgenic rice and weedy rice	423:479	We found that the metabolite profiles of transgenic rice and weedy rice were clearly separated.
33199119	7	17	theme	ecological	1112:1121	arg1	consequences					1123:1134	the ecological consequences	1108:1134	the ecological consequences of the hybrids	1108:1149	Changes in the metabolite levels of transgenic crop-weed hybrids compared to their parents might influence not only the ecological consequences of the hybrids, but also the nutritional quality and food safety.
33199119	4	18	theme	components	711:720	arg1	levels					678:683	similar or intermediate levels	654:683	similar or intermediate levels of most major nutritional components	654:720	The F2 progeny had similar or intermediate levels of most major nutritional components compared with their parents.
33199119	0	19	theme	Compositional	0:12	arg1	differences					14:24	Compositional differences	0:24	Compositional differences in hybrids between protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice and weedy rice accessions.	0:153	Compositional differences in hybrids between protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice and weedy rice accessions.
33199119	1	20	theme	transgenic	201:210	arg1	IX					231:232	transgenic protoporphyrinogen IX	201:232	transgenic protoporphyrinogen IX oxidase-inhibiting herbicide-resistant rice and weedy accessions	201:297	We characterized the metabolites in grains of transgenic protoporphyrinogen IX oxidase-inhibiting herbicide-resistant rice and weedy accessions using GC-MS and examined whether the chemical composition of their hybrids differed from that of the parents.
33199119	2	21	theme	rice	476:479	arg1	profiles					438:445	the metabolite profiles	423:445	the metabolite profiles of transgenic rice and weedy rice	423:479	We found that the metabolite profiles of transgenic rice and weedy rice were clearly separated.
33199119	0	22	theme	rice	138:141	arg1	accessions					143:152	weedy rice accessions	132:152	weedy rice accessions	132:152	Compositional differences in hybrids between protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice and weedy rice accessions.
33199119	5	23	theme	benzoic	826:832	arg1	acid					834:837	benzoic acid	826:837	benzoic acid	826:837	However, levels of galactopyranose, trehalose, xylofuranose, mannitol, and benzoic acid were higher in the F2 progeny.
33199119	1	24	theme	protoporphyrinogen	212:229	arg1	IX					231:232	transgenic protoporphyrinogen IX	201:232	transgenic protoporphyrinogen IX oxidase-inhibiting herbicide-resistant rice and weedy accessions	201:297	We characterized the metabolites in grains of transgenic protoporphyrinogen IX oxidase-inhibiting herbicide-resistant rice and weedy accessions using GC-MS and examined whether the chemical composition of their hybrids differed from that of the parents.
33199119	2	25	theme	weedy	470:474	arg1	rice					476:479	weedy rice	470:479	weedy rice	470:479	We found that the metabolite profiles of transgenic rice and weedy rice were clearly separated.
33199119	1	26	theme	chemical	336:343	arg1	composition					345:355	the chemical composition	332:355	the chemical composition of their hybrids	332:372	We characterized the metabolites in grains of transgenic protoporphyrinogen IX oxidase-inhibiting herbicide-resistant rice and weedy accessions using GC-MS and examined whether the chemical composition of their hybrids differed from that of the parents.
33199119	0	27	theme	weedy	132:136	arg1	accessions					143:152	weedy rice accessions	132:152	weedy rice accessions	132:152	Compositional differences in hybrids between protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice and weedy rice accessions.
33199119	6	28	theme	organic	891:897	arg1	acids					899:903	organic acids	891:903	organic acids	891:903	Some fatty acids and organic acids also showed prominent quantitative differences between the F2 progeny and the parents.
33199119	1	29	theme	IX	231:232	arg1	metabolites					176:186	the metabolites	172:186	the metabolites in grains of transgenic protoporphyrinogen IX oxidase-inhibiting herbicide-resistant rice and weedy accessions	172:297	We characterized the metabolites in grains of transgenic protoporphyrinogen IX oxidase-inhibiting herbicide-resistant rice and weedy accessions using GC-MS and examined whether the chemical composition of their hybrids differed from that of the parents.
33199119	0	30	theme	protoporphyrinogen	45:62	arg1	rice					123:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	Compositional differences in hybrids between protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice and weedy rice accessions.
33199119	4	31	theme	nutritional	699:709	arg1	components					711:720	most major nutritional components	688:720	most major nutritional components	688:720	The F2 progeny had similar or intermediate levels of most major nutritional components compared with their parents.
33199119	2	32	theme	transgenic	450:459	arg1	rice					461:464	transgenic rice	450:464	transgenic rice	450:464	We found that the metabolite profiles of transgenic rice and weedy rice were clearly separated.
33199119	4	33	theme	similar	654:660	arg1	levels					678:683	similar or intermediate levels	654:683	similar or intermediate levels of most major nutritional components	654:720	The F2 progeny had similar or intermediate levels of most major nutritional components compared with their parents.
33199119	7	34	theme	hybrids	1049:1055	arg1	levels					1018:1023	the metabolite levels	1003:1023	the metabolite levels of transgenic crop-weed hybrids	1003:1055	Changes in the metabolite levels of transgenic crop-weed hybrids compared to their parents might influence not only the ecological consequences of the hybrids, but also the nutritional quality and food safety.
33199119	1	35	theme	herbicide-resistant	253:271	arg1	rice					273:276	herbicide-resistant rice and weedy accessions	253:297	rice	273:276	We characterized the metabolites in grains of transgenic protoporphyrinogen IX oxidase-inhibiting herbicide-resistant rice and weedy accessions using GC-MS and examined whether the chemical composition of their hybrids differed from that of the parents.
33199119	0	36	theme	oxidase	67:73	arg1	rice					123:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	Compositional differences in hybrids between protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice and weedy rice accessions.
33199119	5	37	theme	acid	834:837	arg1	levels					760:765	levels	760:765	levels of galactopyranose, trehalose, xylofuranose, mannitol, and benzoic acid	760:837	However, levels of galactopyranose, trehalose, xylofuranose, mannitol, and benzoic acid were higher in the F2 progeny.
33199119	6	38	theme	fatty	875:879	arg1	acids					881:885	Some fatty acids	870:885	Some fatty acids	870:885	Some fatty acids and organic acids also showed prominent quantitative differences between the F2 progeny and the parents.
33199119	0	39	theme	IX	64:65	arg1	rice					123:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	Compositional differences in hybrids between protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice and weedy rice accessions.
33199119	1	40	theme	hybrids	366:372	arg1	composition					345:355	the chemical composition	332:355	the chemical composition of their hybrids	332:372	We characterized the metabolites in grains of transgenic protoporphyrinogen IX oxidase-inhibiting herbicide-resistant rice and weedy accessions using GC-MS and examined whether the chemical composition of their hybrids differed from that of the parents.
33199119	7	41	theme	transgenic	1028:1037	arg1	hybrids					1049:1055	transgenic crop-weed hybrids	1028:1055	transgenic crop-weed hybrids	1028:1055	Changes in the metabolite levels of transgenic crop-weed hybrids compared to their parents might influence not only the ecological consequences of the hybrids, but also the nutritional quality and food safety.
33199119	3	42	theme	F2	541:542	arg1	progeny					544:550	F2 progeny	541:550	F2 progeny	541:550	Although the metabolite profiles of F2 progeny were partially separated from their parents, zygosity did not affect the profiles.
33199119	6	43	theme	F2	964:965	arg1	progeny					967:973	the F2 progeny	960:973	the F2 progeny	960:973	Some fatty acids and organic acids also showed prominent quantitative differences between the F2 progeny and the parents.
33199119	7	44	theme	nutritional	1165:1175	arg1	quality					1177:1183	the nutritional quality	1161:1183	the nutritional quality	1161:1183	Changes in the metabolite levels of transgenic crop-weed hybrids compared to their parents might influence not only the ecological consequences of the hybrids, but also the nutritional quality and food safety.
33199119	4	45	contain	had	650:652	arg1	progeny					642:648	The F2 progeny	635:648	The F2 progeny	635:648	The F2 progeny had similar or intermediate levels of most major nutritional components compared with their parents.
33199119	4	45	contain	had	650:652	arg2	levels					678:683	similar or intermediate levels	654:683	similar or intermediate levels of most major nutritional components	654:720	The F2 progeny had similar or intermediate levels of most major nutritional components compared with their parents.
33199119	7	46	theme	crop-weed	1039:1047	arg1	hybrids					1049:1055	transgenic crop-weed hybrids	1028:1055	transgenic crop-weed hybrids	1028:1055	Changes in the metabolite levels of transgenic crop-weed hybrids compared to their parents might influence not only the ecological consequences of the hybrids, but also the nutritional quality and food safety.
33199119	3	47	theme	metabolite	518:527	arg1	profiles					529:536	the metabolite profiles	514:536	the metabolite profiles of F2 progeny	514:550	Although the metabolite profiles of F2 progeny were partially separated from their parents, zygosity did not affect the profiles.
33199119	7	48	theme	food	1189:1192	arg1	safety					1194:1199	food safety	1189:1199	food safety	1189:1199	Changes in the metabolite levels of transgenic crop-weed hybrids compared to their parents might influence not only the ecological consequences of the hybrids, but also the nutritional quality and food safety.
33199119	4	49	theme	F2	639:640	arg1	progeny					642:648	The F2 progeny	635:648	The F2 progeny	635:648	The F2 progeny had similar or intermediate levels of most major nutritional components compared with their parents.
33199119	0	50	theme	PPO	76:78	arg1	rice					123:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice	45:126	Compositional differences in hybrids between protoporphyrinogen IX oxidase (PPO)-inhibiting herbicide-resistant transgenic rice and weedy rice accessions.
33199119	4	51	theme	intermediate	665:676	arg1	levels					678:683	similar or intermediate levels	654:683	similar or intermediate levels of most major nutritional components	654:720	The F2 progeny had similar or intermediate levels of most major nutritional components compared with their parents.
33199119	4	52	theme	most	688:691	arg1	components					711:720	most major nutritional components	688:720	most major nutritional components	688:720	The F2 progeny had similar or intermediate levels of most major nutritional components compared with their parents.
33199119	1	53	theme	weedy	282:286	arg1	accessions					288:297	herbicide-resistant rice and weedy accessions	253:297	accessions	288:297	We characterized the metabolites in grains of transgenic protoporphyrinogen IX oxidase-inhibiting herbicide-resistant rice and weedy accessions using GC-MS and examined whether the chemical composition of their hybrids differed from that of the parents.
33199119	5	54	theme	xylofuranose	798:809	arg1	levels					760:765	levels	760:765	levels of galactopyranose, trehalose, xylofuranose, mannitol, and benzoic acid	760:837	However, levels of galactopyranose, trehalose, xylofuranose, mannitol, and benzoic acid were higher in the F2 progeny.
33199119	5	55	theme	galactopyranose	770:784	arg1	levels					760:765	levels	760:765	levels of galactopyranose, trehalose, xylofuranose, mannitol, and benzoic acid	760:837	However, levels of galactopyranose, trehalose, xylofuranose, mannitol, and benzoic acid were higher in the F2 progeny.
34186224	8	0	theme	practical	1386:1394	arg1	method					1396:1401	an innovative and practical method	1368:1401	an innovative and practical method for MF	1368:1408	It also provides an innovative and practical method for MF to remediate contaminants in the magnetically enhanced adsorption system.
34186224	1	1	theme	strong	173:178	arg1	applicability					180:192	simple and strong applicability	162:192	simple and strong applicability	162:192	Improving the adsorption performance with simple and strong applicability has always been a research hotspot in water treatment.
34186224	5	2	theme	Cu2+	930:933	arg1	rates					913:917	the adsorption rates	898:917	the adsorption rates of CIP and Cu2+	898:933	The magnetic effect of the adsorption capacity of Cu2+ is not obvious, which indicated the selectivity for adsorption; however, the adsorption rates of CIP and Cu2+ are greatly improved by 359.76% and 371% respectively.
34186224	7	3	theme	external	1204:1211	arg1	field					1222:1226	the external magnetic field	1200:1226	the external magnetic field	1200:1226	The combination of the external magnetic field and the inherent magnetic properties of the adsorbent can adjust the adsorption process and the selectivity of pollutants.
34186224	6	4	theme	surface	1056:1062	arg1	rate					1019:1022	Promoting materials transfer rate	990:1022	Promoting materials transfer rate	990:1022	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	4	theme	surface	1056:1062	arg1	reactivity					1081:1090	surface functional group reactivity	1056:1090	surface functional group reactivity	1056:1090	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	4	theme	surface	1056:1062	arg1	key					1099:1101	key	1099:1101	key	1099:1101	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	4	theme	surface	1056:1062	arg1	changing					1025:1032	changing	1025:1032	changing	1025:1032	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	8	5	theme	adsorption	1465:1474	arg1	system					1476:1481	the magnetically enhanced adsorption system	1439:1481	the magnetically enhanced adsorption system	1439:1481	It also provides an innovative and practical method for MF to remediate contaminants in the magnetically enhanced adsorption system.
34186224	2	6	theme	functional	316:325	arg1	materials					337:345	functional composite materials	316:345	functional composite materials	316:345	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	2	6	theme	functional	316:325	arg1	alginate/MXene/CoFe2O4					278:299	sodium alginate/MXene/CoFe2O4	271:299	sodium alginate/MXene/CoFe2O4 (SA/MX/CFO)	271:311	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	1	7	theme	Improving	120:128	arg1	performance					145:155	the adsorption performance	130:155	Improving the adsorption performance with simple and strong applicability	120:192	Improving the adsorption performance with simple and strong applicability has always been a research hotspot in water treatment.
34186224	1	7	theme	Improving	120:128	arg1	hotspot					221:227	a research hotspot	210:227	a research hotspot	210:227	Improving the adsorption performance with simple and strong applicability has always been a research hotspot in water treatment.
34186224	4	8	theme	isotherm	611:618	arg1	fitting					620:626	The isotherm fitting	607:626	The isotherm fitting	607:626	The isotherm fitting chose Cu2+ and CIP as the model pollutants, the isotherm fitting shows that the adsorption capacity of CIP is significantly improved by 24.2%.
34186224	0	9	theme	magnetic	104:111	arg1	field					113:117	magnetic field	104:117	magnetic field	104:117	Enhanced adsorption performance of alginate/MXene/CoFe2O4 for antibiotic and heavy metal under rotating magnetic field.
34186224	6	10	theme	group	1075:1079	arg1	rate					1019:1022	Promoting materials transfer rate	990:1022	Promoting materials transfer rate	990:1022	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	10	theme	group	1075:1079	arg1	reactivity					1081:1090	surface functional group reactivity	1056:1090	surface functional group reactivity	1056:1090	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	10	theme	group	1075:1079	arg1	key					1099:1101	key	1099:1101	key	1099:1101	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	10	theme	group	1075:1079	arg1	changing					1025:1032	changing	1025:1032	changing	1025:1032	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	8	11	from	contaminants	1423:1434	arg1	system					1476:1481	the magnetically enhanced adsorption system	1439:1481	the magnetically enhanced adsorption system	1439:1481	It also provides an innovative and practical method for MF to remediate contaminants in the magnetically enhanced adsorption system.
34186224	1	12	with	performance	145:155	arg1	applicability					180:192	simple and strong applicability	162:192	simple and strong applicability	162:192	Improving the adsorption performance with simple and strong applicability has always been a research hotspot in water treatment.
34186224	3	13	theme	mechanical	505:514	arg1	properties					516:525	excellent mechanical properties	495:525	excellent mechanical properties	495:525	SA/MX/CFO beads exhibited excellent mechanical properties, with fracture stress of 1.64 MPa at 73.4%, and an elastic modulus of 2.23 MPa.
34186224	4	14	theme	isotherm	676:683	arg1	fitting					685:691	the isotherm fitting	672:691	the isotherm fitting	672:691	The isotherm fitting chose Cu2+ and CIP as the model pollutants, the isotherm fitting shows that the adsorption capacity of CIP is significantly improved by 24.2%.
34186224	6	15	theme	adsorption	1120:1129	arg1	enhancement					1131:1141	the adsorption enhancement	1116:1141	the adsorption enhancement	1116:1141	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	3	16	theme	SA/MX/CFO	469:477	arg1	beads					479:483	SA/MX/CFO beads	469:483	SA/MX/CFO beads	469:483	SA/MX/CFO beads exhibited excellent mechanical properties, with fracture stress of 1.64 MPa at 73.4%, and an elastic modulus of 2.23 MPa.
34186224	0	17	theme	adsorption	9:18	arg1	performance					20:30	adsorption performance	9:30	adsorption performance of alginate/MXene/CoFe2O4 for antibiotic and heavy metal	9:87	Enhanced adsorption performance of alginate/MXene/CoFe2O4 for antibiotic and heavy metal under rotating magnetic field.
34186224	7	18	theme	inherent	1236:1243	arg1	properties					1254:1263	the inherent magnetic properties	1232:1263	the inherent magnetic properties of the adsorbent	1232:1280	The combination of the external magnetic field and the inherent magnetic properties of the adsorbent can adjust the adsorption process and the selectivity of pollutants.
34186224	2	19	from	adsorbents	387:396	arg1	removal					405:411	the removal	401:411	the removal of contaminations with an external magnetic field (MF)	401:466	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	2	20	theme	sodium	350:355	arg1	cross-linking					366:378	sodium alginate cross-linking	350:378	sodium alginate cross-linking	350:378	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	7	21	theme	field	1222:1226	arg1	properties					1254:1263	the inherent magnetic properties	1232:1263	the inherent magnetic properties of the adsorbent	1232:1280	The combination of the external magnetic field and the inherent magnetic properties of the adsorbent can adjust the adsorption process and the selectivity of pollutants.
34186224	7	21	theme	field	1222:1226	arg1	combination					1185:1195	The combination	1181:1195	The combination of the external magnetic field	1181:1226	The combination of the external magnetic field and the inherent magnetic properties of the adsorbent can adjust the adsorption process and the selectivity of pollutants.
34186224	2	22	theme	contaminations	416:429	arg1	removal					405:411	the removal	401:411	the removal of contaminations with an external magnetic field (MF)	401:466	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	5	23	theme	capacity	808:815	arg1	obvious					832:838	obvious	832:838	obvious	832:838	The magnetic effect of the adsorption capacity of Cu2+ is not obvious, which indicated the selectivity for adsorption; however, the adsorption rates of CIP and Cu2+ are greatly improved by 359.76% and 371% respectively.
34186224	5	23	theme	capacity	808:815	arg1	effect					783:788	The magnetic effect	770:788	The magnetic effect of the adsorption capacity of Cu2+	770:823	The magnetic effect of the adsorption capacity of Cu2+ is not obvious, which indicated the selectivity for adsorption; however, the adsorption rates of CIP and Cu2+ are greatly improved by 359.76% and 371% respectively.
34186224	3	24	theme	elastic	578:584	arg1	modulus					586:592	an elastic modulus	575:592	an elastic modulus of 2.23 MPa	575:604	SA/MX/CFO beads exhibited excellent mechanical properties, with fracture stress of 1.64 MPa at 73.4%, and an elastic modulus of 2.23 MPa.
34186224	5	25	theme	CIP	922:924	arg1	rates					913:917	the adsorption rates	898:917	the adsorption rates of CIP and Cu2+	898:933	The magnetic effect of the adsorption capacity of Cu2+ is not obvious, which indicated the selectivity for adsorption; however, the adsorption rates of CIP and Cu2+ are greatly improved by 359.76% and 371% respectively.
34186224	7	26	theme	adsorbent	1272:1280	arg1	properties					1254:1263	the inherent magnetic properties	1232:1263	the inherent magnetic properties of the adsorbent	1232:1280	The combination of the external magnetic field and the inherent magnetic properties of the adsorbent can adjust the adsorption process and the selectivity of pollutants.
34186224	7	26	theme	adsorbent	1272:1280	arg1	combination					1185:1195	The combination	1181:1195	The combination of the external magnetic field	1181:1226	The combination of the external magnetic field and the inherent magnetic properties of the adsorbent can adjust the adsorption process and the selectivity of pollutants.
34186224	6	27	theme	magnetic	1159:1166	arg1	field					1168:1172	a rotating magnetic field	1148:1172	a rotating magnetic field (RMF)	1148:1178	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	27	theme	magnetic	1159:1166	arg1	RMF					1175:1177	RMF	1175:1177	RMF	1175:1177	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	28	theme	transfer	1010:1017	arg1	rate					1019:1022	Promoting materials transfer rate	990:1022	Promoting materials transfer rate	990:1022	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	28	theme	transfer	1010:1017	arg1	reactivity					1081:1090	surface functional group reactivity	1056:1090	surface functional group reactivity	1056:1090	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	28	theme	transfer	1010:1017	arg1	key					1099:1101	key	1099:1101	key	1099:1101	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	28	theme	transfer	1010:1017	arg1	changing					1025:1032	changing	1025:1032	changing	1025:1032	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	1	29	theme	research	212:219	arg1	performance					145:155	the adsorption performance	130:155	Improving the adsorption performance with simple and strong applicability	120:192	Improving the adsorption performance with simple and strong applicability has always been a research hotspot in water treatment.
34186224	1	29	theme	research	212:219	arg1	hotspot					221:227	a research hotspot	210:227	a research hotspot	210:227	Improving the adsorption performance with simple and strong applicability has always been a research hotspot in water treatment.
34186224	5	30	theme	Cu2+	820:823	arg1	capacity					808:815	the adsorption capacity	793:815	the adsorption capacity of Cu2+	793:823	The magnetic effect of the adsorption capacity of Cu2+ is not obvious, which indicated the selectivity for adsorption; however, the adsorption rates of CIP and Cu2+ are greatly improved by 359.76% and 371% respectively.
34186224	2	31	theme	composite	327:335	arg1	materials					337:345	functional composite materials	316:345	functional composite materials	316:345	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	2	31	theme	composite	327:335	arg1	alginate/MXene/CoFe2O4					278:299	sodium alginate/MXene/CoFe2O4	271:299	sodium alginate/MXene/CoFe2O4 (SA/MX/CFO)	271:311	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	3	32	theme	1.64 MPa	552:559	arg1	stress					542:547	fracture stress	533:547	fracture stress of 1.64 MPa	533:559	SA/MX/CFO beads exhibited excellent mechanical properties, with fracture stress of 1.64 MPa at 73.4%, and an elastic modulus of 2.23 MPa.
34186224	5	33	theme	magnetic	774:781	arg1	obvious					832:838	obvious	832:838	obvious	832:838	The magnetic effect of the adsorption capacity of Cu2+ is not obvious, which indicated the selectivity for adsorption; however, the adsorption rates of CIP and Cu2+ are greatly improved by 359.76% and 371% respectively.
34186224	5	33	theme	magnetic	774:781	arg1	effect					783:788	The magnetic effect	770:788	The magnetic effect of the adsorption capacity of Cu2+	770:823	The magnetic effect of the adsorption capacity of Cu2+ is not obvious, which indicated the selectivity for adsorption; however, the adsorption rates of CIP and Cu2+ are greatly improved by 359.76% and 371% respectively.
34186224	1	34	theme	adsorption	134:143	arg1	performance					145:155	the adsorption performance	130:155	Improving the adsorption performance with simple and strong applicability	120:192	Improving the adsorption performance with simple and strong applicability has always been a research hotspot in water treatment.
34186224	1	34	theme	adsorption	134:143	arg1	hotspot					221:227	a research hotspot	210:227	a research hotspot	210:227	Improving the adsorption performance with simple and strong applicability has always been a research hotspot in water treatment.
34186224	4	35	theme	model	654:658	arg1	CIP					643:645	CIP	643:645	CIP	643:645	The isotherm fitting chose Cu2+ and CIP as the model pollutants, the isotherm fitting shows that the adsorption capacity of CIP is significantly improved by 24.2%.
34186224	4	35	theme	model	654:658	arg1	Cu2+					634:637	Cu2+	634:637	Cu2+	634:637	The isotherm fitting chose Cu2+ and CIP as the model pollutants, the isotherm fitting shows that the adsorption capacity of CIP is significantly improved by 24.2%.
34186224	4	35	theme	model	654:658	arg1	pollutants					660:669	the model pollutants	650:669	the model pollutants	650:669	The isotherm fitting chose Cu2+ and CIP as the model pollutants, the isotherm fitting shows that the adsorption capacity of CIP is significantly improved by 24.2%.
34186224	7	36	theme	magnetic	1245:1252	arg1	properties					1254:1263	the inherent magnetic properties	1232:1263	the inherent magnetic properties of the adsorbent	1232:1280	The combination of the external magnetic field and the inherent magnetic properties of the adsorbent can adjust the adsorption process and the selectivity of pollutants.
34186224	2	37	theme	magnetic	448:455	arg1	MF					464:465	MF	464:465	MF	464:465	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	2	37	theme	magnetic	448:455	arg1	field					457:461	an external magnetic field	436:461	an external magnetic field (MF)	436:466	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	0	38	theme	alginate/MXene/CoFe2O4	35:56	arg1	performance					20:30	adsorption performance	9:30	adsorption performance of alginate/MXene/CoFe2O4 for antibiotic and heavy metal	9:87	Enhanced adsorption performance of alginate/MXene/CoFe2O4 for antibiotic and heavy metal under rotating magnetic field.
34186224	7	39	theme	pollutants	1339:1348	arg1	process					1308:1314	the adsorption process	1293:1314	the adsorption process	1293:1314	The combination of the external magnetic field and the inherent magnetic properties of the adsorbent can adjust the adsorption process and the selectivity of pollutants.
34186224	7	39	theme	pollutants	1339:1348	arg1	selectivity					1324:1334	the selectivity	1320:1334	the selectivity of pollutants	1320:1348	The combination of the external magnetic field and the inherent magnetic properties of the adsorbent can adjust the adsorption process and the selectivity of pollutants.
34186224	2	40	theme	external	439:446	arg1	MF					464:465	MF	464:465	MF	464:465	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	2	40	theme	external	439:446	arg1	field					457:461	an external magnetic field	436:461	an external magnetic field (MF)	436:466	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	6	41	theme	materials	1000:1008	arg1	rate					1019:1022	Promoting materials transfer rate	990:1022	Promoting materials transfer rate	990:1022	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	41	theme	materials	1000:1008	arg1	reactivity					1081:1090	surface functional group reactivity	1056:1090	surface functional group reactivity	1056:1090	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	41	theme	materials	1000:1008	arg1	key					1099:1101	key	1099:1101	key	1099:1101	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	41	theme	materials	1000:1008	arg1	changing					1025:1032	changing	1025:1032	changing	1025:1032	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	3	42	theme	2.23 MPa	597:604	arg1	2.23 MPa					597:604	2.23 MPa	597:604	2.23 MPa	597:604	SA/MX/CFO beads exhibited excellent mechanical properties, with fracture stress of 1.64 MPa at 73.4%, and an elastic modulus of 2.23 MPa.
34186224	3	42	theme	2.23 MPa	597:604	arg1	modulus					586:592	an elastic modulus	575:592	an elastic modulus of 2.23 MPa	575:604	SA/MX/CFO beads exhibited excellent mechanical properties, with fracture stress of 1.64 MPa at 73.4%, and an elastic modulus of 2.23 MPa.
34186224	3	42	theme	2.23 MPa	597:604	arg1	%					568:568	73.4%	564:568	73.4%	564:568	SA/MX/CFO beads exhibited excellent mechanical properties, with fracture stress of 1.64 MPa at 73.4%, and an elastic modulus of 2.23 MPa.
34186224	6	43	theme	functional	1064:1073	arg1	rate					1019:1022	Promoting materials transfer rate	990:1022	Promoting materials transfer rate	990:1022	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	43	theme	functional	1064:1073	arg1	reactivity					1081:1090	surface functional group reactivity	1056:1090	surface functional group reactivity	1056:1090	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	43	theme	functional	1064:1073	arg1	key					1099:1101	key	1099:1101	key	1099:1101	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	43	theme	functional	1064:1073	arg1	changing					1025:1032	changing	1025:1032	changing	1025:1032	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	8	44	theme	enhanced	1456:1463	arg1	system					1476:1481	the magnetically enhanced adsorption system	1439:1481	the magnetically enhanced adsorption system	1439:1481	It also provides an innovative and practical method for MF to remediate contaminants in the magnetically enhanced adsorption system.
34186224	3	45	theme	fracture	533:540	arg1	stress					542:547	fracture stress	533:547	fracture stress of 1.64 MPa	533:559	SA/MX/CFO beads exhibited excellent mechanical properties, with fracture stress of 1.64 MPa at 73.4%, and an elastic modulus of 2.23 MPa.
34186224	7	46	theme	adsorption	1297:1306	arg1	process					1308:1314	the adsorption process	1293:1314	the adsorption process	1293:1314	The combination of the external magnetic field and the inherent magnetic properties of the adsorbent can adjust the adsorption process and the selectivity of pollutants.
34186224	8	47	theme	innovative	1371:1380	arg1	method					1396:1401	an innovative and practical method	1368:1401	an innovative and practical method for MF	1368:1408	It also provides an innovative and practical method for MF to remediate contaminants in the magnetically enhanced adsorption system.
34186224	1	48	from	hotspot	221:227	arg1	treatment					238:246	water treatment	232:246	water treatment	232:246	Improving the adsorption performance with simple and strong applicability has always been a research hotspot in water treatment.
34186224	4	49	theme	CIP	731:733	arg1	capacity					719:726	the adsorption capacity	704:726	the adsorption capacity of CIP	704:733	The isotherm fitting chose Cu2+ and CIP as the model pollutants, the isotherm fitting shows that the adsorption capacity of CIP is significantly improved by 24.2%.
34186224	6	50	theme	Promoting	990:998	arg1	rate					1019:1022	Promoting materials transfer rate	990:1022	Promoting materials transfer rate	990:1022	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	50	theme	Promoting	990:998	arg1	reactivity					1081:1090	surface functional group reactivity	1056:1090	surface functional group reactivity	1056:1090	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	50	theme	Promoting	990:998	arg1	key					1099:1101	key	1099:1101	key	1099:1101	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	50	theme	Promoting	990:998	arg1	changing					1025:1032	changing	1025:1032	changing	1025:1032	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	2	51	theme	alginate	357:364	arg1	cross-linking					366:378	sodium alginate cross-linking	350:378	sodium alginate cross-linking	350:378	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	5	52	theme	adsorption	902:911	arg1	rates					913:917	the adsorption rates	898:917	the adsorption rates of CIP and Cu2+	898:933	The magnetic effect of the adsorption capacity of Cu2+ is not obvious, which indicated the selectivity for adsorption; however, the adsorption rates of CIP and Cu2+ are greatly improved by 359.76% and 371% respectively.
34186224	1	53	theme	water	232:236	arg1	treatment					238:246	water treatment	232:246	water treatment	232:246	Improving the adsorption performance with simple and strong applicability has always been a research hotspot in water treatment.
34186224	2	54	theme	sodium	271:276	arg1	materials					337:345	functional composite materials	316:345	functional composite materials	316:345	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	2	54	theme	sodium	271:276	arg1	SA/MX/CFO					302:310	SA/MX/CFO	302:310	SA/MX/CFO	302:310	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	2	54	theme	sodium	271:276	arg1	alginate/MXene/CoFe2O4					278:299	sodium alginate/MXene/CoFe2O4	271:299	sodium alginate/MXene/CoFe2O4 (SA/MX/CFO)	271:311	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	3	55	theme	excellent	495:503	arg1	properties					516:525	excellent mechanical properties	495:525	excellent mechanical properties	495:525	SA/MX/CFO beads exhibited excellent mechanical properties, with fracture stress of 1.64 MPa at 73.4%, and an elastic modulus of 2.23 MPa.
34186224	1	56	theme	simple	162:167	arg1	applicability					180:192	simple and strong applicability	162:192	simple and strong applicability	162:192	Improving the adsorption performance with simple and strong applicability has always been a research hotspot in water treatment.
34186224	6	57	theme	hydrogen	1037:1044	arg1	bond					1046:1049	hydrogen bond	1037:1049	hydrogen bond	1037:1049	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	2	58	with	contaminations	416:429	arg1	MF					464:465	MF	464:465	MF	464:465	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	2	58	with	contaminations	416:429	arg1	field					457:461	an external magnetic field	436:461	an external magnetic field (MF)	436:466	This study introduces sodium alginate/MXene/CoFe2O4 (SA/MX/CFO) as functional composite materials by sodium alginate cross-linking and as adsorbents in the removal of contaminations with an external magnetic field (MF).
34186224	6	59	theme	rotating	1150:1157	arg1	field					1168:1172	a rotating magnetic field	1148:1172	a rotating magnetic field (RMF)	1148:1178	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	6	59	theme	rotating	1150:1157	arg1	RMF					1175:1177	RMF	1175:1177	RMF	1175:1177	Promoting materials transfer rate, changing of hydrogen bond, and surface functional group reactivity is the key to determine the adsorption enhancement with a rotating magnetic field (RMF).
34186224	7	60	theme	magnetic	1213:1220	arg1	field					1222:1226	the external magnetic field	1200:1226	the external magnetic field	1200:1226	The combination of the external magnetic field and the inherent magnetic properties of the adsorbent can adjust the adsorption process and the selectivity of pollutants.
34186224	5	61	theme	adsorption	797:806	arg1	capacity					808:815	the adsorption capacity	793:815	the adsorption capacity of Cu2+	793:823	The magnetic effect of the adsorption capacity of Cu2+ is not obvious, which indicated the selectivity for adsorption; however, the adsorption rates of CIP and Cu2+ are greatly improved by 359.76% and 371% respectively.
34186224	4	62	theme	adsorption	708:717	arg1	capacity					719:726	the adsorption capacity	704:726	the adsorption capacity of CIP	704:733	The isotherm fitting chose Cu2+ and CIP as the model pollutants, the isotherm fitting shows that the adsorption capacity of CIP is significantly improved by 24.2%.
32825916	0	0	theme	real-time	91:99	arg1	monitoring					101:110	real-time monitoring	91:110	real-time monitoring of H2O2 released from living cells	91:145	A novel Fe-hemin-metal organic frameworks supported on chitosan-reduced graphene oxide for real-time monitoring of H2O2 released from living cells.
32825916	6	1	theme	MOFs-based	940:949	arg1	sensors					951:957	MOFs-based sensors	940:957	MOFs-based sensors	940:957	Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells.
32825916	0	2	attach	released	120:127	arg1	cells					141:145	living cells	134:145	living cells	134:145	A novel Fe-hemin-metal organic frameworks supported on chitosan-reduced graphene oxide for real-time monitoring of H2O2 released from living cells.
32825916	0	2	attach	released	120:127	arg2	H2O2					115:118	H2O2	115:118	H2O2 released from living cells	115:145	A novel Fe-hemin-metal organic frameworks supported on chitosan-reduced graphene oxide for real-time monitoring of H2O2 released from living cells.
32825916	4	3	theme	Fe-hemin-MOFs/CS-rGO	535:554	arg1	composite					556:564	The Fe-hemin-MOFs/CS-rGO composite	531:564	The Fe-hemin-MOFs/CS-rGO composite	531:564	The Fe-hemin-MOFs/CS-rGO composite was used to construct a novel H2O2 electrochemical sensor.
32825916	1	4	with	kind	158:161	arg1	bioactivity					253:263	unique peroxidase-like bioactivity	230:263	unique peroxidase-like bioactivity	230:263	Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time.
32825916	5	5	theme	electrocatalytic	629:644	arg1	reduction					646:654	The electrocatalytic reduction	625:654	The electrocatalytic reduction of H2O2	625:662	The electrocatalytic reduction of H2O2 displayed two segments linearity range from 1 to 61 μM and 61-1311 μM, as well as a low detection limit of 0.57 μM.
32825916	2	6	theme	hydrogen	378:385	arg1	peroxide					387:394	hydrogen peroxide	378:394	hydrogen peroxide (H2O2)	378:401	The synthesized Fe-hemin-MOFs exhibited satisfactory catalytic activity toward hydrogen peroxide (H2O2).
32825916	2	6	theme	hydrogen	378:385	arg1	H2O2					397:400	H2O2	397:400	H2O2	397:400	The synthesized Fe-hemin-MOFs exhibited satisfactory catalytic activity toward hydrogen peroxide (H2O2).
32825916	4	7	theme	electrochemical	601:615	arg1	sensor					617:622	a novel H2O2 electrochemical sensor	588:622	a novel H2O2 electrochemical sensor	588:622	The Fe-hemin-MOFs/CS-rGO composite was used to construct a novel H2O2 electrochemical sensor.
32825916	5	8	theme	low	748:750	arg1	limit					762:766	a low detection limit	746:766	a low detection limit of 0.57 μM	746:777	The electrocatalytic reduction of H2O2 displayed two segments linearity range from 1 to 61 μM and 61-1311 μM, as well as a low detection limit of 0.57 μM.
32825916	5	9	theme	detection	752:760	arg1	limit					762:766	a low detection limit	746:766	a low detection limit of 0.57 μM	746:777	The electrocatalytic reduction of H2O2 displayed two segments linearity range from 1 to 61 μM and 61-1311 μM, as well as a low detection limit of 0.57 μM.
32825916	6	10	theme	practical	915:923	arg1	application					925:935	the practical application	911:935	the practical application of MOFs-based sensors	911:957	Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells.
32825916	5	11	dep	61 μM	713:717	arg1	to					710:711	to	710:711	to	710:711	The electrocatalytic reduction of H2O2 displayed two segments linearity range from 1 to 61 μM and 61-1311 μM, as well as a low detection limit of 0.57 μM.
32825916	4	12	used	used	570:573	arg2	composite					556:564	The Fe-hemin-MOFs/CS-rGO composite	531:564	The Fe-hemin-MOFs/CS-rGO composite	531:564	The Fe-hemin-MOFs/CS-rGO composite was used to construct a novel H2O2 electrochemical sensor.
32825916	3	13	theme	amplified	479:487	arg1	signal					505:510	amplified electrochemical signal	479:510	amplified electrochemical signal	479:510	When it was further supported on Chitosan-reduced graphene oxide (CS-rGO), amplified electrochemical signal could be obtained.
32825916	3	14	theme	Chitosan-reduced	437:452	arg1	oxide					463:467	Chitosan-reduced graphene oxide	437:467	Chitosan-reduced graphene oxide (CS-rGO)	437:476	When it was further supported on Chitosan-reduced graphene oxide (CS-rGO), amplified electrochemical signal could be obtained.
32825916	3	14	theme	Chitosan-reduced	437:452	arg1	CS-rGO					470:475	CS-rGO	470:475	CS-rGO	470:475	When it was further supported on Chitosan-reduced graphene oxide (CS-rGO), amplified electrochemical signal could be obtained.
32825916	0	15	theme	H2O2	115:118	arg1	monitoring					101:110	real-time monitoring	91:110	real-time monitoring of H2O2 released from living cells	91:145	A novel Fe-hemin-metal organic frameworks supported on chitosan-reduced graphene oxide for real-time monitoring of H2O2 released from living cells.
32825916	1	16	theme	novel	166:170	arg1	frameworks					198:207	novel hemin-based metal organic frameworks	166:207	novel hemin-based metal organic frameworks (Fe-hemin-MOFs)	166:223	Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time.
32825916	1	16	theme	novel	166:170	arg1	Fe-hemin-MOFs					210:222	Fe-hemin-MOFs	210:222	Fe-hemin-MOFs	210:222	Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time.
32825916	0	17	theme	novel	2:6	arg1	frameworks					31:40	A novel Fe-hemin-metal organic frameworks	0:40	A novel Fe-hemin-metal organic frameworks	0:40	A novel Fe-hemin-metal organic frameworks supported on chitosan-reduced graphene oxide for real-time monitoring of H2O2 released from living cells.
32825916	5	18	theme	segments	678:685	arg1	range					697:701	two segments linearity range	674:701	two segments linearity range from 1 to 61 μM and 61-1311 μM	674:732	The electrocatalytic reduction of H2O2 displayed two segments linearity range from 1 to 61 μM and 61-1311 μM, as well as a low detection limit of 0.57 μM.
32825916	1	19	theme	hemin-based	172:182	arg1	frameworks					198:207	novel hemin-based metal organic frameworks	166:207	novel hemin-based metal organic frameworks (Fe-hemin-MOFs)	166:223	Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time.
32825916	1	19	theme	hemin-based	172:182	arg1	Fe-hemin-MOFs					210:222	Fe-hemin-MOFs	210:222	Fe-hemin-MOFs	210:222	Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time.
32825916	5	20	theme	linearity	687:695	arg1	range					697:701	two segments linearity range	674:701	two segments linearity range from 1 to 61 μM and 61-1311 μM	674:732	The electrocatalytic reduction of H2O2 displayed two segments linearity range from 1 to 61 μM and 61-1311 μM, as well as a low detection limit of 0.57 μM.
32825916	6	21	theme	proposed	797:804	arg1	sensor					806:811	the proposed sensor	793:811	the proposed sensor	793:811	Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells.
32825916	1	22	theme	metal	184:188	arg1	frameworks					198:207	novel hemin-based metal organic frameworks	166:207	novel hemin-based metal organic frameworks (Fe-hemin-MOFs)	166:223	Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time.
32825916	1	22	theme	metal	184:188	arg1	Fe-hemin-MOFs					210:222	Fe-hemin-MOFs	210:222	Fe-hemin-MOFs	210:222	Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time.
32825916	0	23	theme	organic	23:29	arg1	frameworks					31:40	A novel Fe-hemin-metal organic frameworks	0:40	A novel Fe-hemin-metal organic frameworks	0:40	A novel Fe-hemin-metal organic frameworks supported on chitosan-reduced graphene oxide for real-time monitoring of H2O2 released from living cells.
32825916	1	24	theme	first	287:291	arg1	time					293:296	the first time	283:296	the first time	283:296	Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time.
32825916	0	25	theme	living	134:139	arg1	cells					141:145	living cells	134:145	living cells	134:145	A novel Fe-hemin-metal organic frameworks supported on chitosan-reduced graphene oxide for real-time monitoring of H2O2 released from living cells.
32825916	5	26	theme	H2O2	659:662	arg1	reduction					646:654	The electrocatalytic reduction	625:654	The electrocatalytic reduction of H2O2	625:662	The electrocatalytic reduction of H2O2 displayed two segments linearity range from 1 to 61 μM and 61-1311 μM, as well as a low detection limit of 0.57 μM.
32825916	2	27	theme	synthesized	303:313	arg1	Fe-hemin-MOFs					315:327	The synthesized Fe-hemin-MOFs	299:327	The synthesized Fe-hemin-MOFs	299:327	The synthesized Fe-hemin-MOFs exhibited satisfactory catalytic activity toward hydrogen peroxide (H2O2).
32825916	6	28	theme	real-time	839:847	arg1	monitoring					849:858	real-time monitoring	839:858	real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells	839:1012	Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells.
32825916	1	29	theme	organic	190:196	arg1	frameworks					198:207	novel hemin-based metal organic frameworks	166:207	novel hemin-based metal organic frameworks (Fe-hemin-MOFs)	166:223	Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time.
32825916	1	29	theme	organic	190:196	arg1	Fe-hemin-MOFs					210:222	Fe-hemin-MOFs	210:222	Fe-hemin-MOFs	210:222	Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time.
32825916	0	30	theme	Fe-hemin-metal	8:21	arg1	frameworks					31:40	A novel Fe-hemin-metal organic frameworks	0:40	A novel Fe-hemin-metal organic frameworks	0:40	A novel Fe-hemin-metal organic frameworks supported on chitosan-reduced graphene oxide for real-time monitoring of H2O2 released from living cells.
32825916	4	31	theme	H2O2	596:599	arg1	sensor					617:622	a novel H2O2 electrochemical sensor	588:622	a novel H2O2 electrochemical sensor	588:622	The Fe-hemin-MOFs/CS-rGO composite was used to construct a novel H2O2 electrochemical sensor.
32825916	6	32	from	process	990:996	arg1	cells					1008:1012	living cells	1001:1012	living cells	1001:1012	Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells.
32825916	1	33	theme	frameworks	198:207	arg1	kind					158:161	a kind	156:161	a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity	156:263	Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time.
32825916	4	34	theme	novel	590:594	arg1	sensor					617:622	a novel H2O2 electrochemical sensor	588:622	a novel H2O2 electrochemical sensor	588:622	The Fe-hemin-MOFs/CS-rGO composite was used to construct a novel H2O2 electrochemical sensor.
32825916	3	35	theme	graphene	454:461	arg1	oxide					463:467	Chitosan-reduced graphene oxide	437:467	Chitosan-reduced graphene oxide (CS-rGO)	437:476	When it was further supported on Chitosan-reduced graphene oxide (CS-rGO), amplified electrochemical signal could be obtained.
32825916	3	35	theme	graphene	454:461	arg1	CS-rGO					470:475	CS-rGO	470:475	CS-rGO	470:475	When it was further supported on Chitosan-reduced graphene oxide (CS-rGO), amplified electrochemical signal could be obtained.
32825916	6	36	theme	pathological	977:988	arg1	process					990:996	the pathological process	973:996	the pathological process in living cells	973:1012	Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells.
32825916	6	37	theme	living	882:887	arg1	cells					889:893	living cells	882:893	living cells	882:893	Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells.
32825916	5	38	from	61 μM	713:717	arg1	range					697:701	two segments linearity range	674:701	two segments linearity range from 1 to 61 μM and 61-1311 μM	674:732	The electrocatalytic reduction of H2O2 displayed two segments linearity range from 1 to 61 μM and 61-1311 μM, as well as a low detection limit of 0.57 μM.
32825916	0	39	theme	chitosan-reduced	55:70	arg1	oxide					81:85	chitosan-reduced graphene oxide	55:85	chitosan-reduced graphene oxide for real-time monitoring of H2O2 released from living cells	55:145	A novel Fe-hemin-metal organic frameworks supported on chitosan-reduced graphene oxide for real-time monitoring of H2O2 released from living cells.
32825916	6	40	theme	living	1001:1006	arg1	cells					1008:1012	living cells	1001:1012	living cells	1001:1012	Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells.
32825916	6	41	attach	released	868:875	arg1	cells					889:893	living cells	882:893	living cells	882:893	Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells.
32825916	6	41	attach	released	868:875	arg2	H2O2					863:866	H2O2	863:866	H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells	863:1012	Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells.
32825916	6	42	theme	H2O2	863:866	arg1	monitoring					849:858	real-time monitoring	839:858	real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells	839:1012	Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells.
32825916	2	43	theme	catalytic	352:360	arg1	activity					362:369	satisfactory catalytic activity	339:369	satisfactory catalytic activity toward hydrogen peroxide (H2O2)	339:401	The synthesized Fe-hemin-MOFs exhibited satisfactory catalytic activity toward hydrogen peroxide (H2O2).
32825916	5	44	from	61-1311 μM	723:732	arg1	range					697:701	two segments linearity range	674:701	two segments linearity range from 1 to 61 μM and 61-1311 μM	674:732	The electrocatalytic reduction of H2O2 displayed two segments linearity range from 1 to 61 μM and 61-1311 μM, as well as a low detection limit of 0.57 μM.
32825916	6	45	used	used	830:833	arg2	sensor					806:811	the proposed sensor	793:811	the proposed sensor	793:811	Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells.
32825916	2	46	theme	satisfactory	339:350	arg1	activity					362:369	satisfactory catalytic activity	339:369	satisfactory catalytic activity toward hydrogen peroxide (H2O2)	339:401	The synthesized Fe-hemin-MOFs exhibited satisfactory catalytic activity toward hydrogen peroxide (H2O2).
32825916	3	47	theme	electrochemical	489:503	arg1	signal					505:510	amplified electrochemical signal	479:510	amplified electrochemical signal	479:510	When it was further supported on Chitosan-reduced graphene oxide (CS-rGO), amplified electrochemical signal could be obtained.
32825916	5	48	theme	0.57 μM	771:777	arg1	limit					762:766	a low detection limit	746:766	a low detection limit of 0.57 μM	746:777	The electrocatalytic reduction of H2O2 displayed two segments linearity range from 1 to 61 μM and 61-1311 μM, as well as a low detection limit of 0.57 μM.
32825916	1	49	theme	unique	230:235	arg1	bioactivity					253:263	unique peroxidase-like bioactivity	230:263	unique peroxidase-like bioactivity	230:263	Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time.
32825916	0	50	theme	graphene	72:79	arg1	oxide					81:85	chitosan-reduced graphene oxide	55:85	chitosan-reduced graphene oxide for real-time monitoring of H2O2 released from living cells	55:145	A novel Fe-hemin-metal organic frameworks supported on chitosan-reduced graphene oxide for real-time monitoring of H2O2 released from living cells.
32825916	6	51	theme	sensors	951:957	arg1	application					925:935	the practical application	911:935	the practical application of MOFs-based sensors	911:957	Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells.
32825916	1	52	theme	peroxidase-like	237:251	arg1	bioactivity					253:263	unique peroxidase-like bioactivity	230:263	unique peroxidase-like bioactivity	230:263	Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time.
33712136	0	0	theme	osteoinductive	90:103	arg1	properties					105:114	enhanced osteoinductive properties	81:114	enhanced osteoinductive properties	81:114	Hyaluronic acid oligosaccharides modified mineralized collagen and chitosan with enhanced osteoinductive properties for bone tissue engineering.
33712136	3	1	theme	compressive	787:797	arg1	strength					799:806	compressive strength	787:806	compressive strength	787:806	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	2	2	dep	then	541:544	arg1	distributed					556:566	distributed	556:566	uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration	546:740	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	1	3	theme	bone	263:266	arg1	scaffold					286:293	a bone tissue-engineered scaffold	261:293	a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization	261:345	In this study, we prepared a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization.
33712136	0	4	theme	bone	120:123	arg1	engineering					132:142	bone tissue engineering	120:142	bone tissue engineering	120:142	Hyaluronic acid oligosaccharides modified mineralized collagen and chitosan with enhanced osteoinductive properties for bone tissue engineering.
33712136	2	5	theme	interconnected	672:685	arg1	scaffolds					687:695	three-dimensional interconnected scaffolds	654:695	three-dimensional interconnected scaffolds as temporary templates for bone regeneration	654:740	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	4	6	theme	MC3T3-E1	1173:1180	arg1	differentiation					1154:1168	the osteogenic differentiation	1139:1168	the osteogenic differentiation of MC3T3-E1 and BMSCs	1139:1190	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	1	7	theme	tissue-engineered	268:284	arg1	scaffold					286:293	a bone tissue-engineered scaffold	261:293	a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization	261:345	In this study, we prepared a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization.
33712136	2	8	theme	three-dimensional	654:670	arg1	scaffolds					687:695	three-dimensional interconnected scaffolds	654:695	three-dimensional interconnected scaffolds as temporary templates for bone regeneration	654:740	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	3	9	theme	bone	1002:1005	arg1	engineering					1014:1024	bone tissue engineering	1002:1024	bone tissue engineering	1002:1024	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	4	10	theme	oHAs-based	1058:1067	arg1	scaffolds					1069:1077	the oHAs-based scaffolds	1054:1077	the oHAs-based scaffolds	1054:1077	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	2	11	theme	bone	724:727	arg1	regeneration					729:740	bone regeneration	724:740	bone regeneration	724:740	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	2	12	theme	chitosan/hyaluronic	483:501	arg1	CTS/oHAs					526:533	CTS/oHAs	526:533	CTS/oHAs	526:533	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	2	12	theme	chitosan/hyaluronic	483:501	arg1	oligosaccharides					508:523	chitosan/hyaluronic acid oligosaccharides	483:523	chitosan/hyaluronic acid oligosaccharides (CTS/oHAs)	483:534	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	2	12	theme	chitosan/hyaluronic	483:501	arg1	oligosaccharides/hydroxyapatite					435:465	namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite	403:465	namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP)	403:480	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	3	13	theme	tissue	1007:1012	arg1	engineering					1014:1024	bone tissue engineering	1002:1024	bone tissue engineering	1002:1024	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	1	14	theme	biomimetic	174:183	arg1	scaffold					241:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold	172:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization	172:345	In this study, we prepared a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization.
33712136	0	15	theme	tissue	125:130	arg1	engineering					132:142	bone tissue engineering	120:142	bone tissue engineering	120:142	Hyaluronic acid oligosaccharides modified mineralized collagen and chitosan with enhanced osteoinductive properties for bone tissue engineering.
33712136	3	16	theme	degradation	813:823	arg1	behavior					825:832	degradation behavior	813:832	degradation behavior of the fabricated scaffolds	813:860	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	4	17	contain	have	1197:1200	arg2	capacity					1249:1256	ideal biocompatibility and tissue regenerative capacity	1202:1256	capacity	1249:1256	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	4	17	contain	have	1197:1200	arg2	biocompatibility					1208:1223	ideal biocompatibility and tissue regenerative capacity	1202:1256	biocompatibility	1208:1223	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	4	17	contain	have	1197:1200	arg1	scaffolds					1069:1077	the oHAs-based scaffolds	1054:1077	the oHAs-based scaffolds	1054:1077	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	4	18	theme	tissue	1330:1335	arg1	applications					1349:1360	bone tissue engineering applications	1325:1360	bone tissue engineering applications	1325:1360	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	1	19	theme	hyaluronic	185:194	arg1	scaffold					241:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold	172:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization	172:345	In this study, we prepared a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization.
33712136	3	20	dep	in	928:929	arg1	vivo					931:934	vivo	931:934	vivo	931:934	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	4	21	theme	bone	1325:1328	arg1	applications					1349:1360	bone tissue engineering applications	1325:1360	bone tissue engineering applications	1325:1360	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	2	22	theme	functional	352:361	arg1	products					368:375	The functional oHAs products	348:375	The functional oHAs products	348:375	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	1	23	theme	acid	196:199	arg1	scaffold					241:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold	172:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization	172:345	In this study, we prepared a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization.
33712136	0	24	theme	Hyaluronic	0:9	arg1	acid					11:14	Hyaluronic acid	0:14	Hyaluronic acid	0:14	Hyaluronic acid oligosaccharides modified mineralized collagen and chitosan with enhanced osteoinductive properties for bone tissue engineering.
33712136	2	25	theme	temporary	700:708	arg1	templates					710:718	temporary templates	700:718	temporary templates for bone regeneration	700:740	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	2	26	theme	acid	430:433	arg1	oligosaccharides					508:523	chitosan/hyaluronic acid oligosaccharides	483:523	chitosan/hyaluronic acid oligosaccharides (CTS/oHAs)	483:534	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	2	26	theme	acid	430:433	arg1	Col/oHAs/HAP					468:479	Col/oHAs/HAP	468:479	Col/oHAs/HAP	468:479	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	2	26	theme	acid	430:433	arg1	oligosaccharides/hydroxyapatite					435:465	namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite	403:465	namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP)	403:480	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	0	27	theme	modified	33:40	arg1	collagen					54:61	modified mineralized collagen	33:61	modified mineralized collagen	33:61	Hyaluronic acid oligosaccharides modified mineralized collagen and chitosan with enhanced osteoinductive properties for bone tissue engineering.
33712136	4	28	theme	engineering	1337:1347	arg1	applications					1349:1360	bone tissue engineering applications	1325:1360	bone tissue engineering applications	1325:1360	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	4	29	theme	ideal	1202:1206	arg1	biocompatibility					1208:1223	ideal biocompatibility and tissue regenerative capacity	1202:1256	biocompatibility	1208:1223	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	2	30	theme	acid	503:506	arg1	CTS/oHAs					526:533	CTS/oHAs	526:533	CTS/oHAs	526:533	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	2	30	theme	acid	503:506	arg1	oligosaccharides					508:523	chitosan/hyaluronic acid oligosaccharides	483:523	chitosan/hyaluronic acid oligosaccharides (CTS/oHAs)	483:534	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	2	30	theme	acid	503:506	arg1	oligosaccharides/hydroxyapatite					435:465	namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite	403:465	namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP)	403:480	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	3	31	theme	fabricated	841:850	arg1	scaffolds					852:860	the fabricated scaffolds	837:860	the fabricated scaffolds	837:860	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	4	32	theme	tissue	1229:1234	arg1	capacity					1249:1256	ideal biocompatibility and tissue regenerative capacity	1202:1256	capacity	1249:1256	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	1	33	theme	oHAs	219:222	arg1	scaffold					241:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold	172:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization	172:345	In this study, we prepared a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization.
33712136	3	34	theme	scaffolds	852:860	arg1	behavior					825:832	degradation behavior	813:832	degradation behavior of the fabricated scaffolds	813:860	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	3	34	theme	scaffolds	852:860	arg1	morphology					747:756	The morphology	743:756	The morphology	743:756	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	3	34	theme	scaffolds	852:860	arg1	properties					775:784	physicochemical properties	759:784	physicochemical properties	759:784	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	3	34	theme	scaffolds	852:860	arg1	responses					888:896	in vitro cell responses	874:896	in vitro cell responses seeded on these scaffolds and in vivo biocompatibility	874:951	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	3	34	theme	scaffolds	852:860	arg1	strength					799:806	compressive strength	787:806	compressive strength	787:806	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	1	35	theme	oligosaccharides	201:216	arg1	scaffold					241:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold	172:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization	172:345	In this study, we prepared a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization.
33712136	0	36	theme	mineralized	42:52	arg1	collagen					54:61	modified mineralized collagen	33:61	modified mineralized collagen	33:61	Hyaluronic acid oligosaccharides modified mineralized collagen and chitosan with enhanced osteoinductive properties for bone tissue engineering.
33712136	3	37	theme	in	874:875	arg1	responses					888:896	in vitro cell responses	874:896	in vitro cell responses seeded on these scaffolds and in vivo biocompatibility	874:951	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	3	38	theme	in	928:929	arg1	biocompatibility					936:951	in vivo biocompatibility	928:951	in vivo biocompatibility	928:951	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	4	39	theme	osteogenic	1143:1152	arg1	differentiation					1154:1168	the osteogenic differentiation	1139:1168	the osteogenic differentiation of MC3T3-E1 and BMSCs	1139:1190	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	4	40	theme	alternative	1298:1308	arg1	candidates					1310:1319	alternative candidates	1298:1319	alternative candidates for bone tissue engineering applications	1298:1360	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	1	41	theme	-based	224:229	arg1	scaffold					241:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold	172:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization	172:345	In this study, we prepared a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization.
33712136	4	42	theme	cells	1121:1125	arg1	attachment					1095:1104	the attachment	1091:1104	the attachment of endothelial cells	1091:1125	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	4	43	theme	regenerative	1236:1247	arg1	capacity					1249:1256	ideal biocompatibility and tissue regenerative capacity	1202:1256	capacity	1249:1256	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	3	44	dep	in	874:875	arg1	vitro					877:881	vitro	877:881	vitro	877:881	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	4	45	theme	endothelial	1109:1119	arg1	cells					1121:1125	endothelial cells	1109:1125	endothelial cells	1109:1125	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	2	46	theme	lactic-co-glycolic	577:594	arg1	poly					571:574	poly	571:574	poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration	571:740	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	2	46	theme	lactic-co-glycolic	577:594	arg1	acid					596:599	lactic-co-glycolic acid	577:599	lactic-co-glycolic acid	577:599	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	1	47	theme	composite	231:239	arg1	scaffold					241:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold	172:248	a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization	172:345	In this study, we prepared a biomimetic hyaluronic acid oligosaccharides (oHAs)-based composite scaffold to develop a bone tissue-engineered scaffold for stimulating osteogenesis and endothelialization.
33712136	0	48	with	chitosan	67:74	arg1	properties					105:114	enhanced osteoinductive properties	81:114	enhanced osteoinductive properties	81:114	Hyaluronic acid oligosaccharides modified mineralized collagen and chitosan with enhanced osteoinductive properties for bone tissue engineering.
33712136	2	49	theme	oHAs	363:366	arg1	products					368:375	The functional oHAs products	348:375	The functional oHAs products	348:375	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	0	50	theme	enhanced	81:88	arg1	properties					105:114	enhanced osteoinductive properties	81:114	enhanced osteoinductive properties	81:114	Hyaluronic acid oligosaccharides modified mineralized collagen and chitosan with enhanced osteoinductive properties for bone tissue engineering.
33712136	3	51	theme	physicochemical	759:773	arg1	properties					775:784	physicochemical properties	759:784	physicochemical properties	759:784	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	2	52	theme	collagen/hyaluronic	410:428	arg1	oligosaccharides					508:523	chitosan/hyaluronic acid oligosaccharides	483:523	chitosan/hyaluronic acid oligosaccharides (CTS/oHAs)	483:534	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	2	52	theme	collagen/hyaluronic	410:428	arg1	Col/oHAs/HAP					468:479	Col/oHAs/HAP	468:479	Col/oHAs/HAP	468:479	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	2	52	theme	collagen/hyaluronic	410:428	arg1	oligosaccharides/hydroxyapatite					435:465	namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite	403:465	namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP)	403:480	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	4	53	theme	BMSCs	1186:1190	arg1	differentiation					1154:1168	the osteogenic differentiation	1139:1168	the osteogenic differentiation of MC3T3-E1 and BMSCs	1139:1190	The results indicated that the oHAs-based scaffolds can promote the attachment of endothelial cells, facilitate the osteogenic differentiation of MC3T3-E1 and BMSCs, and have ideal biocompatibility and tissue regenerative capacity, suggesting their potential to serve as alternative candidates for bone tissue engineering applications.
33712136	3	54	theme	cell	883:886	arg1	responses					888:896	in vitro cell responses	874:896	in vitro cell responses seeded on these scaffolds and in vivo biocompatibility	874:951	The morphology, physicochemical properties, compressive strength, and degradation behavior of the fabricated scaffolds, as well as in vitro cell responses seeded on these scaffolds and in vivo biocompatibility, were investigated to evaluate the potential for bone tissue engineering.
33712136	2	55	theme	poly	571:574	arg1	solution					609:616	poly (lactic-co-glycolic acid) (PLGA) solution	571:616	poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration	571:740	The functional oHAs products were firstly synthesized, namely collagen/hyaluronic acid oligosaccharides/hydroxyapatite (Col/oHAs/HAP), chitosan/hyaluronic acid oligosaccharides (CTS/oHAs), and then uniformly distributed in poly (lactic-co-glycolic acid) (PLGA) solution followed by freeze-drying to obtain three-dimensional interconnected scaffolds as temporary templates for bone regeneration.
33712136	0	56	with	collagen	54:61	arg1	properties					105:114	enhanced osteoinductive properties	81:114	enhanced osteoinductive properties	81:114	Hyaluronic acid oligosaccharides modified mineralized collagen and chitosan with enhanced osteoinductive properties for bone tissue engineering.
33393184	3	0	theme	proteomic	318:326	arg1	analysis					328:335	high-resolution proteomic analysis	302:335	high-resolution proteomic analysis	302:335	This study takes the advantage of high-resolution proteomic analysis to unveil the protein compositions.
33393184	6	1	theme	biosynthetic	578:589	arg1	approach					591:598	A biosynthetic approach	576:598	A biosynthetic approach	576:598	A biosynthetic approach is used to fabricate a glue protein by a modified Escherichia coli recombinant system.
33393184	8	2	theme	cellular	906:913	arg1	viability					915:923	cellular viability	906:923	cellular viability	906:923	It is found that the purified recombinant protein shows enhanced performance to cellular viability.
33393184	8	3	theme	purified	847:854	arg1	protein					868:874	the purified recombinant protein	843:874	the purified recombinant protein	843:874	It is found that the purified recombinant protein shows enhanced performance to cellular viability.
33393184	3	4	theme	analysis	328:335	arg1	advantage					289:297	the advantage	285:297	the advantage of high-resolution proteomic analysis	285:335	This study takes the advantage of high-resolution proteomic analysis to unveil the protein compositions.
33393184	6	5	theme	Escherichia	650:660	arg1	system					679:684	a modified Escherichia coli recombinant system	639:684	a modified Escherichia coli recombinant system	639:684	A biosynthetic approach is used to fabricate a glue protein by a modified Escherichia coli recombinant system.
33393184	6	6	theme	modified	641:648	arg1	system					679:684	a modified Escherichia coli recombinant system	639:684	a modified Escherichia coli recombinant system	639:684	A biosynthetic approach is used to fabricate a glue protein by a modified Escherichia coli recombinant system.
33393184	4	7	theme	chitin-binding	411:424	arg1	motifs					426:431	chitin-binding motifs	411:431	chitin-binding motifs	411:431	A glue protein group is identified as chitin-binding motifs by bioinformatic analysis.
33393184	4	7	theme	chitin-binding	411:424	arg1	group					388:392	A glue protein group	373:392	A glue protein group	373:392	A glue protein group is identified as chitin-binding motifs by bioinformatic analysis.
33393184	1	8	theme	Glue	61:64	arg1	protein					66:72	Glue protein	61:72	Glue protein as secretion from fruit fly larva	61:106	Glue protein as secretion from fruit fly larva plays a significant role in metamorphosis as cementing material for pupation sites.
33393184	8	9	theme	recombinant	856:866	arg1	protein					868:874	the purified recombinant protein	843:874	the purified recombinant protein	843:874	It is found that the purified recombinant protein shows enhanced performance to cellular viability.
33393184	5	10	theme	binding	535:541	arg1	site					543:546	the binding site	531:546	the binding site between protein and chitin	531:573	Computational modeling analysis of representative proteins illustrates the binding site between protein and chitin.
33393184	1	11	theme	cementing	153:161	arg1	material					163:170	cementing material	153:170	cementing material for pupation sites	153:189	Glue protein as secretion from fruit fly larva plays a significant role in metamorphosis as cementing material for pupation sites.
33393184	3	12	theme	protein	351:357	arg1	compositions					359:370	the protein compositions	347:370	the protein compositions	347:370	This study takes the advantage of high-resolution proteomic analysis to unveil the protein compositions.
33393184	4	13	theme	glue	375:378	arg1	motifs					426:431	chitin-binding motifs	411:431	chitin-binding motifs	411:431	A glue protein group is identified as chitin-binding motifs by bioinformatic analysis.
33393184	4	13	theme	glue	375:378	arg1	group					388:392	A glue protein group	373:392	A glue protein group	373:392	A glue protein group is identified as chitin-binding motifs by bioinformatic analysis.
33393184	0	14	theme	Biomimetic	2:11	arg1	Protein					18:24	A Biomimetic Glue Protein	0:24	A Biomimetic Glue Protein	0:24	A Biomimetic Glue Protein Modulates Hepatic Gene Expression.
33393184	9	15	theme	cell	1018:1021	arg1	culture					1023:1029	cell culture	1018:1029	cell culture	1018:1029	This finding provides a potential biomacromolecule candidate as an extracellular matrix for cell culture.
33393184	7	16	theme	glue	720:723	arg1	protein					725:731	The as-biosynthesized biomimetic glue protein	687:731	The as-biosynthesized biomimetic glue protein	687:731	The as-biosynthesized biomimetic glue protein is applied as an extracellular matrix to investigate its biocompatibility and functionality.
33393184	7	16	theme	glue	720:723	arg1	matrix					764:769	an extracellular matrix	747:769	an extracellular matrix	747:769	The as-biosynthesized biomimetic glue protein is applied as an extracellular matrix to investigate its biocompatibility and functionality.
33393184	1	17	from	larva	102:106	arg1	secretion					77:85	secretion	77:85	secretion from fruit fly larva	77:106	Glue protein as secretion from fruit fly larva plays a significant role in metamorphosis as cementing material for pupation sites.
33393184	1	18	theme	pupation	176:183	arg1	sites					185:189	pupation sites	176:189	pupation sites	176:189	Glue protein as secretion from fruit fly larva plays a significant role in metamorphosis as cementing material for pupation sites.
33393184	4	19	theme	protein	380:386	arg1	motifs					426:431	chitin-binding motifs	411:431	chitin-binding motifs	411:431	A glue protein group is identified as chitin-binding motifs by bioinformatic analysis.
33393184	4	19	theme	protein	380:386	arg1	group					388:392	A glue protein group	373:392	A glue protein group	373:392	A glue protein group is identified as chitin-binding motifs by bioinformatic analysis.
33393184	1	20	theme	fruit	92:96	arg1	fly					98:100	fruit fly	92:100	fruit fly larva	92:106	Glue protein as secretion from fruit fly larva plays a significant role in metamorphosis as cementing material for pupation sites.
33393184	5	21	theme	representative	495:508	arg1	proteins					510:517	representative proteins	495:517	representative proteins	495:517	Computational modeling analysis of representative proteins illustrates the binding site between protein and chitin.
33393184	0	22	theme	Glue	13:16	arg1	Protein					18:24	A Biomimetic Glue Protein	0:24	A Biomimetic Glue Protein	0:24	A Biomimetic Glue Protein Modulates Hepatic Gene Expression.
33393184	6	23	used	used	603:606	arg2	approach					591:598	A biosynthetic approach	576:598	A biosynthetic approach	576:598	A biosynthetic approach is used to fabricate a glue protein by a modified Escherichia coli recombinant system.
33393184	1	24	theme	fly	98:100	arg1	larva					102:106	fruit fly larva	92:106	fruit fly larva	92:106	Glue protein as secretion from fruit fly larva plays a significant role in metamorphosis as cementing material for pupation sites.
33393184	5	25	theme	proteins	510:517	arg1	analysis					483:490	Computational modeling analysis	460:490	Computational modeling analysis of representative proteins	460:517	Computational modeling analysis of representative proteins illustrates the binding site between protein and chitin.
33393184	0	26	theme	Hepatic	36:42	arg1	Expression					49:58	Hepatic Gene Expression	36:58	Hepatic Gene Expression	36:58	A Biomimetic Glue Protein Modulates Hepatic Gene Expression.
33393184	7	27	theme	extracellular	750:762	arg1	protein					725:731	The as-biosynthesized biomimetic glue protein	687:731	The as-biosynthesized biomimetic glue protein	687:731	The as-biosynthesized biomimetic glue protein is applied as an extracellular matrix to investigate its biocompatibility and functionality.
33393184	7	27	theme	extracellular	750:762	arg1	matrix					764:769	an extracellular matrix	747:769	an extracellular matrix	747:769	The as-biosynthesized biomimetic glue protein is applied as an extracellular matrix to investigate its biocompatibility and functionality.
33393184	9	28	theme	potential	950:958	arg1	candidate					977:985	a potential biomacromolecule candidate	948:985	a potential biomacromolecule candidate as an extracellular matrix for cell culture	948:1029	This finding provides a potential biomacromolecule candidate as an extracellular matrix for cell culture.
33393184	7	29	theme	as-biosynthesized	691:707	arg1	protein					725:731	The as-biosynthesized biomimetic glue protein	687:731	The as-biosynthesized biomimetic glue protein	687:731	The as-biosynthesized biomimetic glue protein is applied as an extracellular matrix to investigate its biocompatibility and functionality.
33393184	7	29	theme	as-biosynthesized	691:707	arg1	matrix					764:769	an extracellular matrix	747:769	an extracellular matrix	747:769	The as-biosynthesized biomimetic glue protein is applied as an extracellular matrix to investigate its biocompatibility and functionality.
33393184	6	30	dep	Escherichia	650:660	arg1	coli					662:665	coli	662:665	coli	662:665	A biosynthetic approach is used to fabricate a glue protein by a modified Escherichia coli recombinant system.
33393184	9	31	theme	biomacromolecule	960:975	arg1	candidate					977:985	a potential biomacromolecule candidate	948:985	a potential biomacromolecule candidate as an extracellular matrix for cell culture	948:1029	This finding provides a potential biomacromolecule candidate as an extracellular matrix for cell culture.
33393184	2	32	theme	biochemical	205:215	arg1	composition					217:227	the biochemical composition	201:227	the biochemical composition of this macromolecule	201:249	However, the biochemical composition of this macromolecule remains obscure.
33393184	0	33	theme	Gene	44:47	arg1	Expression					49:58	Hepatic Gene Expression	36:58	Hepatic Gene Expression	36:58	A Biomimetic Glue Protein Modulates Hepatic Gene Expression.
33393184	3	34	theme	high-resolution	302:316	arg1	analysis					328:335	high-resolution proteomic analysis	302:335	high-resolution proteomic analysis	302:335	This study takes the advantage of high-resolution proteomic analysis to unveil the protein compositions.
33393184	8	35	theme	enhanced	882:889	arg1	performance					891:901	enhanced performance	882:901	enhanced performance	882:901	It is found that the purified recombinant protein shows enhanced performance to cellular viability.
33393184	5	36	theme	Computational	460:472	arg1	analysis					483:490	Computational modeling analysis	460:490	Computational modeling analysis of representative proteins	460:517	Computational modeling analysis of representative proteins illustrates the binding site between protein and chitin.
33393184	7	37	theme	biomimetic	709:718	arg1	protein					725:731	The as-biosynthesized biomimetic glue protein	687:731	The as-biosynthesized biomimetic glue protein	687:731	The as-biosynthesized biomimetic glue protein is applied as an extracellular matrix to investigate its biocompatibility and functionality.
33393184	7	37	theme	biomimetic	709:718	arg1	matrix					764:769	an extracellular matrix	747:769	an extracellular matrix	747:769	The as-biosynthesized biomimetic glue protein is applied as an extracellular matrix to investigate its biocompatibility and functionality.
33393184	1	38	theme	significant	116:126	arg1	role					128:131	a significant role	114:131	a significant role	114:131	Glue protein as secretion from fruit fly larva plays a significant role in metamorphosis as cementing material for pupation sites.
33393184	5	39	theme	modeling	474:481	arg1	analysis					483:490	Computational modeling analysis	460:490	Computational modeling analysis of representative proteins	460:517	Computational modeling analysis of representative proteins illustrates the binding site between protein and chitin.
33393184	9	40	theme	extracellular	993:1005	arg1	matrix					1007:1012	an extracellular matrix	990:1012	an extracellular matrix for cell culture	990:1029	This finding provides a potential biomacromolecule candidate as an extracellular matrix for cell culture.
33393184	4	41	theme	bioinformatic	436:448	arg1	analysis					450:457	bioinformatic analysis	436:457	bioinformatic analysis	436:457	A glue protein group is identified as chitin-binding motifs by bioinformatic analysis.
33393184	2	42	theme	macromolecule	237:249	arg1	composition					217:227	the biochemical composition	201:227	the biochemical composition of this macromolecule	201:249	However, the biochemical composition of this macromolecule remains obscure.
33393184	6	43	theme	glue	623:626	arg1	protein					628:634	a glue protein	621:634	a glue protein	621:634	A biosynthetic approach is used to fabricate a glue protein by a modified Escherichia coli recombinant system.
33393184	6	44	theme	recombinant	667:677	arg1	system					679:684	a modified Escherichia coli recombinant system	639:684	a modified Escherichia coli recombinant system	639:684	A biosynthetic approach is used to fabricate a glue protein by a modified Escherichia coli recombinant system.
32570929	2	0	theme	microcrystalline	323:338	arg1	MCC					351:353	MCC	351:353	MCC	351:353	In this study, the extraction of microcrystalline cellulose (MCC) was performed using bamboo fibers through acid hydrolysis and subsequently different characterizations were carried out using various advanced techniques.
32570929	2	0	theme	microcrystalline	323:338	arg1	cellulose					340:348	microcrystalline cellulose	323:348	microcrystalline cellulose (MCC)	323:354	In this study, the extraction of microcrystalline cellulose (MCC) was performed using bamboo fibers through acid hydrolysis and subsequently different characterizations were carried out using various advanced techniques.
32570929	5	1	theme	Pure	734:737	arg1	MCC					739:741	Pure MCC	734:741	Pure MCC	734:741	Pure MCC, albeit with small quantities of impurities and residues, was obtained, as revealed by Energy Dispersive X-ray (EDX) analysis.
32570929	6	2	theme	82.6	948:951	arg1	%					943:943	%	943:943	%	943:943	X-ray diffraction (XRD) indicates the increase in crystallinity from 62.5% to 82.6%.
32570929	6	3	theme	X-ray	870:874	arg1	XRD					889:891	XRD	889:891	XRD	889:891	X-ray diffraction (XRD) indicates the increase in crystallinity from 62.5% to 82.6%.
32570929	6	3	theme	X-ray	870:874	arg1	diffraction					876:886	X-ray diffraction	870:886	X-ray diffraction (XRD)	870:892	X-ray diffraction (XRD) indicates the increase in crystallinity from 62.5% to 82.6%.
32570929	8	4	theme	analysis	1098:1105	arg1	results					1067:1073	The results	1063:1073	The results of thermal gravimetric analysis (TGA)	1063:1111	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	4	5	theme	rough	684:688	arg1	surface					690:696	rough surface	684:696	rough surface	684:696	Scanning Electron Microscopy (SEM) revealed rough surface and minor agglomeration of the MCC.
32570929	8	6	theme	MCC	1162:1164	arg1	stability					1140:1148	better thermal stability	1125:1148	better thermal stability of isolated MCC compared to its starting material (Bamboo fibers)	1125:1214	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	8	7	theme	gravimetric	1086:1096	arg1	TGA					1108:1110	TGA	1108:1110	TGA	1108:1110	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	8	7	theme	gravimetric	1086:1096	arg1	analysis					1098:1105	thermal gravimetric analysis	1078:1105	thermal gravimetric analysis (TGA)	1078:1111	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	8	8	theme	thermal	1078:1084	arg1	TGA					1108:1110	TGA	1108:1110	TGA	1108:1110	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	8	8	theme	thermal	1078:1084	arg1	analysis					1098:1105	thermal gravimetric analysis	1078:1105	thermal gravimetric analysis (TGA)	1078:1111	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	9	9	theme	crystalline	1391:1401	arg1	nanocellulose					1403:1415	crystalline nanocellulose	1391:1415	crystalline nanocellulose	1391:1415	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	6	10	theme	62.5	939:942	arg1	%					943:943	%	943:943	%	943:943	X-ray diffraction (XRD) indicates the increase in crystallinity from 62.5% to 82.6%.
32570929	4	11	theme	minor	702:706	arg1	agglomeration					708:720	minor agglomeration	702:720	minor agglomeration	702:720	Scanning Electron Microscopy (SEM) revealed rough surface and minor agglomeration of the MCC.
32570929	7	12	theme	available	1042:1050	arg1	MCC					1052:1054	commercial available MCC	1031:1054	commercial available MCC (74%)	1031:1060	Furthermore, the isolated MCC has slightly higher crystallinity compared to commercial available MCC (74%).
32570929	7	12	theme	available	1042:1050	arg1	%					1059:1059	74%	1057:1059	74%	1057:1059	Furthermore, the isolated MCC has slightly higher crystallinity compared to commercial available MCC (74%).
32570929	8	13	theme	starting	1182:1189	arg1	material					1191:1198	its starting material	1178:1198	its starting material	1178:1198	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	3	14	from	MCC	608:610	arg1	removal					585:591	the removal	581:591	the removal of lignin from MCC extracted from bamboo pulp	581:637	Fourier transform infrared (FTIR) spectroscopy analysis has indicated the removal of lignin from MCC extracted from bamboo pulp.
32570929	0	15	theme	Bamboo	104:109	arg1	Fiber					111:115	Bamboo Fiber	104:115	Bamboo Fiber	104:115	Morphological, Physiochemical and Thermal Properties of Microcrystalline Cellulose (MCC) Extracted from Bamboo Fiber.
32570929	9	16	theme	isolated	1227:1234	arg1	element					1271:1277	a reinforcing element	1257:1277	a reinforcing element for the production of green composites	1257:1316	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	9	16	theme	isolated	1227:1234	arg1	MCC					1236:1238	the isolated MCC	1223:1238	the isolated MCC	1223:1238	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	9	17	theme	composites	1307:1316	arg1	production					1287:1296	the production	1283:1296	the production of green composites	1283:1316	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	1	18	used	utilized	136:143	arg2	fibers					125:130	Bamboo fibers	118:130	Bamboo fibers	118:130	Bamboo fibers are utilized for the production of various structures, building materials, etc. and is of great significance all over the world especially in southeast Asia.
32570929	7	19	contain	has	985:987	arg1	MCC					981:983	the isolated MCC	968:983	the isolated MCC	968:983	Furthermore, the isolated MCC has slightly higher crystallinity compared to commercial available MCC (74%).
32570929	7	19	contain	has	985:987	arg2	crystallinity					1005:1017	slightly higher crystallinity	989:1017	slightly higher crystallinity	989:1017	Furthermore, the isolated MCC has slightly higher crystallinity compared to commercial available MCC (74%).
32570929	1	20	theme	various	167:173	arg1	structures					175:184	various structures	167:184	various structures	167:184	Bamboo fibers are utilized for the production of various structures, building materials, etc. and is of great significance all over the world especially in southeast Asia.
32570929	4	21	theme	MCC	729:731	arg1	surface					690:696	rough surface	684:696	rough surface	684:696	Scanning Electron Microscopy (SEM) revealed rough surface and minor agglomeration of the MCC.
32570929	4	21	theme	MCC	729:731	arg1	agglomeration					708:720	minor agglomeration	702:720	minor agglomeration	702:720	Scanning Electron Microscopy (SEM) revealed rough surface and minor agglomeration of the MCC.
32570929	1	22	theme	structures	175:184	arg1	production					153:162	the production	149:162	the production of various structures, building materials, etc. and is of great significance all over the world	149:258	Bamboo fibers are utilized for the production of various structures, building materials, etc. and is of great significance all over the world especially in southeast Asia.
32570929	0	23	theme	Morphological	0:12	arg1	Properties					42:51	Morphological, Physiochemical and Thermal Properties	0:51	Morphological, Physiochemical and Thermal Properties of Microcrystalline Cellulose (MCC)	0:87	Morphological, Physiochemical and Thermal Properties of Microcrystalline Cellulose (MCC) Extracted from Bamboo Fiber.
32570929	7	24	theme	commercial	1031:1040	arg1	MCC					1052:1054	commercial available MCC	1031:1054	commercial available MCC (74%)	1031:1060	Furthermore, the isolated MCC has slightly higher crystallinity compared to commercial available MCC (74%).
32570929	7	24	theme	commercial	1031:1040	arg1	%					1059:1059	74%	1057:1059	74%	1057:1059	Furthermore, the isolated MCC has slightly higher crystallinity compared to commercial available MCC (74%).
32570929	7	25	theme	higher	998:1003	arg1	crystallinity					1005:1017	slightly higher crystallinity	989:1017	slightly higher crystallinity	989:1017	Furthermore, the isolated MCC has slightly higher crystallinity compared to commercial available MCC (74%).
32570929	5	26	theme	Energy	830:835	arg1	analysis					860:867	Energy Dispersive X-ray (EDX) analysis	830:867	Energy Dispersive X-ray (EDX) analysis	830:867	Pure MCC, albeit with small quantities of impurities and residues, was obtained, as revealed by Energy Dispersive X-ray (EDX) analysis.
32570929	5	27	theme	X-ray	848:852	arg1	analysis					860:867	Energy Dispersive X-ray (EDX) analysis	830:867	Energy Dispersive X-ray (EDX) analysis	830:867	Pure MCC, albeit with small quantities of impurities and residues, was obtained, as revealed by Energy Dispersive X-ray (EDX) analysis.
32570929	8	28	theme	better	1125:1130	arg1	stability					1140:1148	better thermal stability	1125:1148	better thermal stability of isolated MCC compared to its starting material (Bamboo fibers)	1125:1214	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	5	29	theme	residues	791:798	arg1	quantities					762:771	small quantities	756:771	small quantities of impurities and residues	756:798	Pure MCC, albeit with small quantities of impurities and residues, was obtained, as revealed by Energy Dispersive X-ray (EDX) analysis.
32570929	5	30	dep	albeit	744:749	arg1	with					751:754	with	751:754	with	751:754	Pure MCC, albeit with small quantities of impurities and residues, was obtained, as revealed by Energy Dispersive X-ray (EDX) analysis.
32570929	9	31	from	production	1377:1386	arg1	future					1420:1425	future	1420:1425	future	1420:1425	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	3	32	theme	spectroscopy	545:556	arg1	analysis					558:565	spectroscopy analysis	545:565	spectroscopy analysis	545:565	Fourier transform infrared (FTIR) spectroscopy analysis has indicated the removal of lignin from MCC extracted from bamboo pulp.
32570929	9	33	used	utilized	1337:1344	arg2	it					1322:1323	it	1322:1323	it	1322:1323	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	9	33	used	utilized	1337:1344	arg2	material					1360:1367	a starting material	1349:1367	a starting material for the production of crystalline nanocellulose in future	1349:1425	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	1	34	theme	building	187:194	arg1	materials					196:204	building materials	187:204	building materials	187:204	Bamboo fibers are utilized for the production of various structures, building materials, etc. and is of great significance all over the world especially in southeast Asia.
32570929	2	35	theme	acid	398:401	arg1	hydrolysis					403:412	acid hydrolysis	398:412	acid hydrolysis	398:412	In this study, the extraction of microcrystalline cellulose (MCC) was performed using bamboo fibers through acid hydrolysis and subsequently different characterizations were carried out using various advanced techniques.
32570929	6	36	from	increase	908:915	arg1	crystallinity					920:932	crystallinity	920:932	crystallinity	920:932	X-ray diffraction (XRD) indicates the increase in crystallinity from 62.5% to 82.6%.
32570929	1	37	theme	materials	196:204	arg1	production					153:162	the production	149:162	the production of various structures, building materials, etc. and is of great significance all over the world	149:258	Bamboo fibers are utilized for the production of various structures, building materials, etc. and is of great significance all over the world especially in southeast Asia.
32570929	5	38	theme	small	756:760	arg1	quantities					762:771	small quantities	756:771	small quantities of impurities and residues	756:798	Pure MCC, albeit with small quantities of impurities and residues, was obtained, as revealed by Energy Dispersive X-ray (EDX) analysis.
32570929	1	39	theme	southeast	274:282	arg1	Asia					284:287	southeast Asia	274:287	southeast Asia	274:287	Bamboo fibers are utilized for the production of various structures, building materials, etc. and is of great significance all over the world especially in southeast Asia.
32570929	4	40	theme	Scanning	640:647	arg1	Microscopy					658:667	Scanning Electron Microscopy	640:667	Scanning Electron Microscopy (SEM)	640:673	Scanning Electron Microscopy (SEM) revealed rough surface and minor agglomeration of the MCC.
32570929	4	40	theme	Scanning	640:647	arg1	SEM					670:672	SEM	670:672	SEM	670:672	Scanning Electron Microscopy (SEM) revealed rough surface and minor agglomeration of the MCC.
32570929	1	41	dep	structures	175:184	arg1	all					241:243	all	241:243	all	241:243	Bamboo fibers are utilized for the production of various structures, building materials, etc. and is of great significance all over the world especially in southeast Asia.
32570929	2	42	theme	bamboo	376:381	arg1	fibers					383:388	bamboo fibers	376:388	bamboo fibers	376:388	In this study, the extraction of microcrystalline cellulose (MCC) was performed using bamboo fibers through acid hydrolysis and subsequently different characterizations were carried out using various advanced techniques.
32570929	0	43	theme	Thermal	34:40	arg1	Properties					42:51	Morphological, Physiochemical and Thermal Properties	0:51	Morphological, Physiochemical and Thermal Properties of Microcrystalline Cellulose (MCC)	0:87	Morphological, Physiochemical and Thermal Properties of Microcrystalline Cellulose (MCC) Extracted from Bamboo Fiber.
32570929	5	44	theme	Dispersive	837:846	arg1	analysis					860:867	Energy Dispersive X-ray (EDX) analysis	830:867	Energy Dispersive X-ray (EDX) analysis	830:867	Pure MCC, albeit with small quantities of impurities and residues, was obtained, as revealed by Energy Dispersive X-ray (EDX) analysis.
32570929	3	45	theme	bamboo	627:632	arg1	pulp					634:637	bamboo pulp	627:637	bamboo pulp	627:637	Fourier transform infrared (FTIR) spectroscopy analysis has indicated the removal of lignin from MCC extracted from bamboo pulp.
32570929	3	46	theme	lignin	596:601	arg1	removal					585:591	the removal	581:591	the removal of lignin from MCC extracted from bamboo pulp	581:637	Fourier transform infrared (FTIR) spectroscopy analysis has indicated the removal of lignin from MCC extracted from bamboo pulp.
32570929	1	47	theme	etc.	207:210	arg1	production					153:162	the production	149:162	the production of various structures, building materials, etc. and is of great significance all over the world	149:258	Bamboo fibers are utilized for the production of various structures, building materials, etc. and is of great significance all over the world especially in southeast Asia.
32570929	0	48	theme	Microcrystalline	56:71	arg1	MCC					84:86	MCC	84:86	MCC	84:86	Morphological, Physiochemical and Thermal Properties of Microcrystalline Cellulose (MCC) Extracted from Bamboo Fiber.
32570929	0	48	theme	Microcrystalline	56:71	arg1	Cellulose					73:81	Microcrystalline Cellulose	56:81	Microcrystalline Cellulose (MCC)	56:87	Morphological, Physiochemical and Thermal Properties of Microcrystalline Cellulose (MCC) Extracted from Bamboo Fiber.
32570929	9	49	theme	reinforcing	1259:1269	arg1	element					1271:1277	a reinforcing element	1257:1277	a reinforcing element for the production of green composites	1257:1316	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	9	49	theme	reinforcing	1259:1269	arg1	MCC					1236:1238	the isolated MCC	1223:1238	the isolated MCC	1223:1238	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	5	50	theme	impurities	776:785	arg1	quantities					762:771	small quantities	756:771	small quantities of impurities and residues	756:798	Pure MCC, albeit with small quantities of impurities and residues, was obtained, as revealed by Energy Dispersive X-ray (EDX) analysis.
32570929	0	51	theme	Cellulose	73:81	arg1	Properties					42:51	Morphological, Physiochemical and Thermal Properties	0:51	Morphological, Physiochemical and Thermal Properties of Microcrystalline Cellulose (MCC)	0:87	Morphological, Physiochemical and Thermal Properties of Microcrystalline Cellulose (MCC) Extracted from Bamboo Fiber.
32570929	3	52	dep	infrared	529:536	arg1	FTIR					539:542	FTIR	539:542	FTIR	539:542	Fourier transform infrared (FTIR) spectroscopy analysis has indicated the removal of lignin from MCC extracted from bamboo pulp.
32570929	2	53	theme	different	431:439	arg1	characterizations					441:457	different characterizations	431:457	different characterizations	431:457	In this study, the extraction of microcrystalline cellulose (MCC) was performed using bamboo fibers through acid hydrolysis and subsequently different characterizations were carried out using various advanced techniques.
32570929	8	54	theme	thermal	1132:1138	arg1	stability					1140:1148	better thermal stability	1125:1148	better thermal stability of isolated MCC compared to its starting material (Bamboo fibers)	1125:1214	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	1	55	theme	Bamboo	118:123	arg1	fibers					125:130	Bamboo fibers	118:130	Bamboo fibers	118:130	Bamboo fibers are utilized for the production of various structures, building materials, etc. and is of great significance all over the world especially in southeast Asia.
32570929	8	56	theme	Bamboo	1201:1206	arg1	fibers					1208:1213	Bamboo fibers	1201:1213	Bamboo fibers	1201:1213	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	8	56	theme	Bamboo	1201:1206	arg1	MCC					1162:1164	isolated MCC	1153:1164	isolated MCC compared to its starting material (Bamboo fibers)	1153:1214	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	8	57	dep	compared	1166:1173	arg1	fibers					1208:1213	Bamboo fibers	1201:1213	Bamboo fibers	1201:1213	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	8	57	dep	compared	1166:1173	arg1	MCC					1162:1164	isolated MCC	1153:1164	isolated MCC compared to its starting material (Bamboo fibers)	1153:1214	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	9	58	theme	starting	1351:1358	arg1	it					1322:1323	it	1322:1323	it	1322:1323	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	9	58	theme	starting	1351:1358	arg1	material					1360:1367	a starting material	1349:1367	a starting material for the production of crystalline nanocellulose in future	1349:1425	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	7	59	theme	isolated	972:979	arg1	MCC					981:983	the isolated MCC	968:983	the isolated MCC	968:983	Furthermore, the isolated MCC has slightly higher crystallinity compared to commercial available MCC (74%).
32570929	5	60	theme	EDX	855:857	arg1	analysis					860:867	Energy Dispersive X-ray (EDX) analysis	830:867	Energy Dispersive X-ray (EDX) analysis	830:867	Pure MCC, albeit with small quantities of impurities and residues, was obtained, as revealed by Energy Dispersive X-ray (EDX) analysis.
32570929	8	61	theme	isolated	1153:1160	arg1	MCC					1162:1164	isolated MCC	1153:1164	isolated MCC compared to its starting material (Bamboo fibers)	1153:1214	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	8	61	theme	isolated	1153:1160	arg1	fibers					1208:1213	Bamboo fibers	1201:1213	Bamboo fibers	1201:1213	The results of thermal gravimetric analysis (TGA) demonstrate better thermal stability of isolated MCC compared to its starting material (Bamboo fibers).
32570929	1	62	theme	is	216:217	arg1	production					153:162	the production	149:162	the production of various structures, building materials, etc. and is of great significance all over the world	149:258	Bamboo fibers are utilized for the production of various structures, building materials, etc. and is of great significance all over the world especially in southeast Asia.
32570929	2	63	theme	advanced	490:497	arg1	techniques					499:508	various advanced techniques	482:508	various advanced techniques	482:508	In this study, the extraction of microcrystalline cellulose (MCC) was performed using bamboo fibers through acid hydrolysis and subsequently different characterizations were carried out using various advanced techniques.
32570929	9	64	theme	nanocellulose	1403:1415	arg1	production					1377:1386	the production	1373:1386	the production of crystalline nanocellulose in future	1373:1425	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	9	65	used	used	1249:1252	arg2	MCC					1236:1238	the isolated MCC	1223:1238	the isolated MCC	1223:1238	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	9	65	used	used	1249:1252	arg2	element					1271:1277	a reinforcing element	1257:1277	a reinforcing element for the production of green composites	1257:1316	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	4	66	theme	Electron	649:656	arg1	Microscopy					658:667	Scanning Electron Microscopy	640:667	Scanning Electron Microscopy (SEM)	640:673	Scanning Electron Microscopy (SEM) revealed rough surface and minor agglomeration of the MCC.
32570929	4	66	theme	Electron	649:656	arg1	SEM					670:672	SEM	670:672	SEM	670:672	Scanning Electron Microscopy (SEM) revealed rough surface and minor agglomeration of the MCC.
32570929	2	67	theme	various	482:488	arg1	techniques					499:508	various advanced techniques	482:508	various advanced techniques	482:508	In this study, the extraction of microcrystalline cellulose (MCC) was performed using bamboo fibers through acid hydrolysis and subsequently different characterizations were carried out using various advanced techniques.
32570929	6	68	dep	%	943:943	arg1	to					945:946	to	945:946	to	945:946	X-ray diffraction (XRD) indicates the increase in crystallinity from 62.5% to 82.6%.
32570929	0	69	theme	Physiochemical	15:28	arg1	Properties					42:51	Morphological, Physiochemical and Thermal Properties	0:51	Morphological, Physiochemical and Thermal Properties of Microcrystalline Cellulose (MCC)	0:87	Morphological, Physiochemical and Thermal Properties of Microcrystalline Cellulose (MCC) Extracted from Bamboo Fiber.
32570929	2	70	theme	cellulose	340:348	arg1	extraction					309:318	the extraction	305:318	the extraction of microcrystalline cellulose (MCC)	305:354	In this study, the extraction of microcrystalline cellulose (MCC) was performed using bamboo fibers through acid hydrolysis and subsequently different characterizations were carried out using various advanced techniques.
32570929	9	71	theme	green	1301:1305	arg1	composites					1307:1316	green composites	1301:1316	green composites	1301:1316	Thus, the isolated MCC might be used as a reinforcing element for the production of green composites and it can also be utilized as a starting material for the production of crystalline nanocellulose in future.
32570929	1	72	theme	great	222:226	arg1	significance					228:239	great significance	222:239	great significance	222:239	Bamboo fibers are utilized for the production of various structures, building materials, etc. and is of great significance all over the world especially in southeast Asia.
34731804	0	0	theme	de	83:84	arg1	plastic					91:97	novel corn starch/nata de coco plastic film	60:102	novel corn starch/nata de coco plastic film	60:102	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	3	1	theme	hybrid	660:665	arg1	ratio					667:671	0.5:0.5 wt hybrid ratio	649:671	0.5:0.5 wt hybrid ratio	649:671	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	4	2	theme	high	783:786	arg1	CS					811:812	0.3:0.7 wt CS	800:812	0.3:0.7 wt CS:NDC	800:816	The properties of the films were highly affected by the homogeneity of the sample during hybridization, with high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties.
34731804	4	2	theme	high	783:786	arg1	amount					792:797	high NDC amount	783:797	high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties	783:884	The properties of the films were highly affected by the homogeneity of the sample during hybridization, with high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties.
34731804	2	3	from	ratio	404:408	arg1	plasticizer					372:382	plasticizer	372:382	plasticizer at different weight ratio and weight percent, respectively	372:441	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	2	3	from	ratio	404:408	arg1	coco					316:319	Corn starch (CS)/nata de coco	291:319	Corn starch (CS)/nata de coco (NDC)	291:325	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	2	4	theme	/nata	307:311	arg1	plasticizer					372:382	plasticizer	372:382	plasticizer at different weight ratio and weight percent, respectively	372:441	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	2	4	theme	/nata	307:311	arg1	NDC					322:324	NDC	322:324	NDC	322:324	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	2	4	theme	/nata	307:311	arg1	coco					316:319	Corn starch (CS)/nata de coco	291:319	Corn starch (CS)/nata de coco (NDC)	291:325	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	4	5	theme	0.3:0.7 wt	800:809	arg1	CS					811:812	0.3:0.7 wt CS	800:812	0.3:0.7 wt CS:NDC	800:816	The properties of the films were highly affected by the homogeneity of the sample during hybridization, with high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties.
34731804	4	5	theme	0.3:0.7 wt	800:809	arg1	amount					792:797	high NDC amount	783:797	high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties	783:884	The properties of the films were highly affected by the homogeneity of the sample during hybridization, with high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties.
34731804	1	6	theme	food	211:214	arg1	sources					216:222	food sources	211:222	food sources	211:222	The objective of this work was to develop a plastic film from food sources with excellent thermal, mechanical, and degradability performance.
34731804	0	7	theme	starch/nata	71:81	arg1	plastic					91:97	novel corn starch/nata de coco plastic film	60:102	novel corn starch/nata de coco plastic film	60:102	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	6	8	with	Hybridization	1030:1042	arg1	glycerin					1076:1083	2 phr glycerin	1070:1083	2 phr glycerin	1070:1083	Hybridization of 0.5:0.5 wt CS/NDC with 2 phr glycerin provided the optimum Young's modulus (15.67 MPa) and tensile strength (1.67 MPa) properties.
34731804	0	9	dep	Thermal	105:111	arg1	mechanical					114:123	mechanical	114:123	mechanical	114:123	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	0	10	from	Effect	0:5	arg1	plastic					91:97	novel corn starch/nata de coco plastic film	60:102	novel corn starch/nata de coco plastic film	60:102	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	5	11	theme	glycerin	891:898	arg1	content					900:906	The glycerin content	887:906	The glycerin content	887:906	The glycerin content, however, did not significantly affect the hydrophobicity, water solubility, and degradability properties of CS/NDC film.
34731804	0	12	theme	coco	86:89	arg1	plastic					91:97	novel corn starch/nata de coco plastic film	60:102	novel corn starch/nata de coco plastic film	60:102	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	4	13	theme	NDC	788:790	arg1	CS					811:812	0.3:0.7 wt CS	800:812	0.3:0.7 wt CS:NDC	800:816	The properties of the films were highly affected by the homogeneity of the sample during hybridization, with high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties.
34731804	4	13	theme	NDC	788:790	arg1	amount					792:797	high NDC amount	783:797	high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties	783:884	The properties of the films were highly affected by the homogeneity of the sample during hybridization, with high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties.
34731804	1	14	theme	excellent	229:237	arg1	performance					278:288	excellent thermal, mechanical, and degradability performance	229:288	excellent thermal, mechanical, and degradability performance	229:288	The objective of this work was to develop a plastic film from food sources with excellent thermal, mechanical, and degradability performance.
34731804	4	15	theme	mechanical	852:861	arg1	properties					875:884	mechanical and thermal properties	852:884	mechanical and thermal properties	852:884	The properties of the films were highly affected by the homogeneity of the sample during hybridization, with high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties.
34731804	3	16	theme	0.5:0.5 wt	649:658	arg1	ratio					667:671	0.5:0.5 wt hybrid ratio	649:671	0.5:0.5 wt hybrid ratio	649:671	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	4	17	theme	films	696:700	arg1	properties					678:687	The properties	674:687	The properties of the films	674:700	The properties of the films were highly affected by the homogeneity of the sample during hybridization, with high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties.
34731804	6	18	theme	Young	1106:1110	arg1	15.67 MPa					1123:1131	15.67 MPa	1123:1131	15.67 MPa	1123:1131	Hybridization of 0.5:0.5 wt CS/NDC with 2 phr glycerin provided the optimum Young's modulus (15.67 MPa) and tensile strength (1.67 MPa) properties.
34731804	6	18	theme	Young	1106:1110	arg1	modulus					1114:1120	the optimum Young's modulus	1094:1120	the optimum Young's modulus (15.67 MPa)	1094:1132	Hybridization of 0.5:0.5 wt CS/NDC with 2 phr glycerin provided the optimum Young's modulus (15.67 MPa) and tensile strength (1.67 MPa) properties.
34731804	2	19	theme	different	387:395	arg1	ratio					404:408	different weight ratio	387:408	different weight ratio	387:408	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	3	20	theme	film	638:641	arg1	properties					578:587	degradation properties	566:587	degradation properties	566:587	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	3	20	theme	film	638:641	arg1	properties					530:539	the film forming properties	513:539	the film forming properties	513:539	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	3	20	theme	film	638:641	arg1	solubility					620:629	solubility	620:629	solubility	620:629	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	3	20	theme	film	638:641	arg1	hydrophobicity					601:614	hydrophobicity	601:614	hydrophobicity	601:614	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	4	21	theme	sample	749:754	arg1	homogeneity					730:740	the homogeneity	726:740	the homogeneity of the sample during hybridization	726:775	The properties of the films were highly affected by the homogeneity of the sample during hybridization, with high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties.
34731804	4	22	dep	CS	811:812	arg1	NDC					814:816	NDC	814:816	0.3:0.7 wt CS:NDC	800:816	The properties of the films were highly affected by the homogeneity of the sample during hybridization, with high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties.
34731804	2	23	theme	weight	414:419	arg1	percent					421:427	weight percent	414:427	weight percent	414:427	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	6	24	theme	tensile	1138:1144	arg1	strength					1146:1153	tensile strength	1138:1153	tensile strength (1.67 MPa)	1138:1164	Hybridization of 0.5:0.5 wt CS/NDC with 2 phr glycerin provided the optimum Young's modulus (15.67 MPa) and tensile strength (1.67 MPa) properties.
34731804	6	24	theme	tensile	1138:1144	arg1	1.67 MPa					1156:1163	1.67 MPa	1156:1163	1.67 MPa	1156:1163	Hybridization of 0.5:0.5 wt CS/NDC with 2 phr glycerin provided the optimum Young's modulus (15.67 MPa) and tensile strength (1.67 MPa) properties.
34731804	4	25	theme	thermal	867:873	arg1	properties					875:884	mechanical and thermal properties	852:884	mechanical and thermal properties	852:884	The properties of the films were highly affected by the homogeneity of the sample during hybridization, with high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties.
34731804	5	26	theme	degradability	989:1001	arg1	properties					1003:1012	the hydrophobicity, water solubility, and degradability properties	947:1012	the hydrophobicity, water solubility, and degradability properties of CS/NDC film	947:1027	The glycerin content, however, did not significantly affect the hydrophobicity, water solubility, and degradability properties of CS/NDC film.
34731804	4	27	gly	homogeneity	730:740	arg1	sample					749:754	the sample	745:754	the sample during hybridization	745:775	The properties of the films were highly affected by the homogeneity of the sample during hybridization, with high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties.
34731804	1	28	theme	thermal	239:245	arg1	performance					278:288	excellent thermal, mechanical, and degradability performance	229:288	excellent thermal, mechanical, and degradability performance	229:288	The objective of this work was to develop a plastic film from food sources with excellent thermal, mechanical, and degradability performance.
34731804	6	29	theme	CS/NDC	1058:1063	arg1	Hybridization					1030:1042	Hybridization	1030:1042	Hybridization of 0.5:0.5 wt CS/NDC with 2 phr glycerin	1030:1083	Hybridization of 0.5:0.5 wt CS/NDC with 2 phr glycerin provided the optimum Young's modulus (15.67 MPa) and tensile strength (1.67 MPa) properties.
34731804	0	30	theme	composition	24:34	arg1	Effect					0:5	Effect	0:5	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.	0:147	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	6	31	dep	modulus	1114:1120	arg1	properties					1166:1175	properties	1166:1175	properties	1166:1175	Hybridization of 0.5:0.5 wt CS/NDC with 2 phr glycerin provided the optimum Young's modulus (15.67 MPa) and tensile strength (1.67 MPa) properties.
34731804	3	32	theme	CS	492:493	arg1	hybridization					475:487	the hybridization	471:487	the hybridization of CS with NDC	471:502	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	1	33	theme	work	171:174	arg1	objective					153:161	The objective	149:161	The objective of this work	149:174	The objective of this work was to develop a plastic film from food sources with excellent thermal, mechanical, and degradability performance.
34731804	0	34	theme	hybridization	10:22	arg1	composition					24:34	hybridization composition	10:34	hybridization composition	10:34	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	1	35	theme	mechanical	248:257	arg1	performance					278:288	excellent thermal, mechanical, and degradability performance	229:288	excellent thermal, mechanical, and degradability performance	229:288	The objective of this work was to develop a plastic film from food sources with excellent thermal, mechanical, and degradability performance.
34731804	6	36	theme	phr	1072:1074	arg1	glycerin					1076:1083	2 phr glycerin	1070:1083	2 phr glycerin	1070:1083	Hybridization of 0.5:0.5 wt CS/NDC with 2 phr glycerin provided the optimum Young's modulus (15.67 MPa) and tensile strength (1.67 MPa) properties.
34731804	2	37	from	percent	421:427	arg1	plasticizer					372:382	plasticizer	372:382	plasticizer at different weight ratio and weight percent, respectively	372:441	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	2	37	from	percent	421:427	arg1	coco					316:319	Corn starch (CS)/nata de coco	291:319	Corn starch (CS)/nata de coco (NDC)	291:325	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	3	38	theme	Sample	444:449	arg1	analysis					451:458	Sample analysis	444:458	Sample analysis	444:458	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	0	39	theme	glycerin	40:47	arg1	content					49:55	glycerin content	40:55	glycerin content	40:55	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	4	40	theme	poor	827:830	arg1	hydrophobicity					832:845	poor hydrophobicity	827:845	poor hydrophobicity	827:845	The properties of the films were highly affected by the homogeneity of the sample during hybridization, with high NDC amount (0.3:0.7 wt CS:NDC) showing poor hydrophobicity, and mechanical and thermal properties.
34731804	5	41	theme	water	967:971	arg1	solubility					973:982	water solubility	967:982	water solubility	967:982	The glycerin content, however, did not significantly affect the hydrophobicity, water solubility, and degradability properties of CS/NDC film.
34731804	3	42	theme	forming	522:528	arg1	properties					530:539	the film forming properties	513:539	the film forming properties	513:539	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	3	43	with	hybridization	475:487	arg1	NDC					500:502	NDC	500:502	NDC	500:502	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	1	44	from	sources	216:222	arg1	film					201:204	a plastic film	191:204	a plastic film from food sources with excellent thermal, mechanical, and degradability performance	191:288	The objective of this work was to develop a plastic film from food sources with excellent thermal, mechanical, and degradability performance.
34731804	5	45	theme	solubility	973:982	arg1	properties					1003:1012	the hydrophobicity, water solubility, and degradability properties	947:1012	the hydrophobicity, water solubility, and degradability properties of CS/NDC film	947:1027	The glycerin content, however, did not significantly affect the hydrophobicity, water solubility, and degradability properties of CS/NDC film.
34731804	2	46	theme	weight	397:402	arg1	ratio					404:408	different weight ratio	387:408	different weight ratio	387:408	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	1	47	theme	degradability	264:276	arg1	performance					278:288	excellent thermal, mechanical, and degradability performance	229:288	excellent thermal, mechanical, and degradability performance	229:288	The objective of this work was to develop a plastic film from food sources with excellent thermal, mechanical, and degradability performance.
34731804	0	48	theme	degradation	130:140	arg1	study					142:146	Thermal, mechanical, and degradation study	105:146	study	142:146	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	3	49	theme	degradation	566:576	arg1	properties					578:587	degradation properties	566:587	degradation properties	566:587	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	0	50	theme	content	49:55	arg1	Effect					0:5	Effect	0:5	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.	0:147	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	3	51	theme	film	517:520	arg1	properties					530:539	the film forming properties	513:539	the film forming properties	513:539	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	3	52	theme	mechanical	542:551	arg1	properties					530:539	the film forming properties	513:539	the film forming properties	513:539	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	2	53	theme	starch	296:301	arg1	plasticizer					372:382	plasticizer	372:382	plasticizer at different weight ratio and weight percent, respectively	372:441	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	2	53	theme	starch	296:301	arg1	NDC					322:324	NDC	322:324	NDC	322:324	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	2	53	theme	starch	296:301	arg1	coco					316:319	Corn starch (CS)/nata de coco	291:319	Corn starch (CS)/nata de coco (NDC)	291:325	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	6	54	theme	0.5:0.5 wt	1047:1056	arg1	CS/NDC					1058:1063	0.5:0.5 wt CS/NDC	1047:1063	0.5:0.5 wt CS/NDC	1047:1063	Hybridization of 0.5:0.5 wt CS/NDC with 2 phr glycerin provided the optimum Young's modulus (15.67 MPa) and tensile strength (1.67 MPa) properties.
34731804	3	55	theme	thermal	557:563	arg1	properties					530:539	the film forming properties	513:539	the film forming properties	513:539	Sample analysis found that the hybridization of CS with NDC improved the film forming properties, mechanical and thermal, degradation properties, as well as hydrophobicity and solubility of the film up to 0.5:0.5 wt hybrid ratio.
34731804	1	56	with	film	201:204	arg1	performance					278:288	excellent thermal, mechanical, and degradability performance	229:288	excellent thermal, mechanical, and degradability performance	229:288	The objective of this work was to develop a plastic film from food sources with excellent thermal, mechanical, and degradability performance.
34731804	2	57	theme	Corn	291:294	arg1	CS					304:305	CS	304:305	CS	304:305	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	2	57	theme	Corn	291:294	arg1	starch					296:301	Corn starch	291:301	Corn starch (CS)/nata de coco (NDC)	291:325	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	1	58	theme	plastic	193:199	arg1	film					201:204	a plastic film	191:204	a plastic film from food sources with excellent thermal, mechanical, and degradability performance	191:288	The objective of this work was to develop a plastic film from food sources with excellent thermal, mechanical, and degradability performance.
34731804	0	59	theme	corn	66:69	arg1	plastic					91:97	novel corn starch/nata de coco plastic film	60:102	novel corn starch/nata de coco plastic film	60:102	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	5	60	theme	hydrophobicity	951:964	arg1	properties					1003:1012	the hydrophobicity, water solubility, and degradability properties	947:1012	the hydrophobicity, water solubility, and degradability properties of CS/NDC film	947:1027	The glycerin content, however, did not significantly affect the hydrophobicity, water solubility, and degradability properties of CS/NDC film.
34731804	6	61	theme	optimum	1098:1104	arg1	15.67 MPa					1123:1131	15.67 MPa	1123:1131	15.67 MPa	1123:1131	Hybridization of 0.5:0.5 wt CS/NDC with 2 phr glycerin provided the optimum Young's modulus (15.67 MPa) and tensile strength (1.67 MPa) properties.
34731804	6	61	theme	optimum	1098:1104	arg1	modulus					1114:1120	the optimum Young's modulus	1094:1120	the optimum Young's modulus (15.67 MPa)	1094:1132	Hybridization of 0.5:0.5 wt CS/NDC with 2 phr glycerin provided the optimum Young's modulus (15.67 MPa) and tensile strength (1.67 MPa) properties.
34731804	2	62	theme	glycerin	360:367	arg1	addition					348:355	addition	348:355	addition of glycerin	348:367	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	5	63	theme	film	1024:1027	arg1	properties					1003:1012	the hydrophobicity, water solubility, and degradability properties	947:1012	the hydrophobicity, water solubility, and degradability properties of CS/NDC film	947:1027	The glycerin content, however, did not significantly affect the hydrophobicity, water solubility, and degradability properties of CS/NDC film.
34731804	0	64	theme	novel	60:64	arg1	plastic					91:97	novel corn starch/nata de coco plastic film	60:102	novel corn starch/nata de coco plastic film	60:102	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	5	65	theme	CS/NDC	1017:1022	arg1	film					1024:1027	CS/NDC film	1017:1027	CS/NDC film	1017:1027	The glycerin content, however, did not significantly affect the hydrophobicity, water solubility, and degradability properties of CS/NDC film.
34731804	0	66	dep	Effect	0:5	arg1	Thermal					105:111	Thermal	105:111	Thermal	105:111	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	0	66	dep	Effect	0:5	arg1	study					142:146	Thermal, mechanical, and degradation study	105:146	study	142:146	Effect of hybridization composition and glycerin content on novel corn starch/nata de coco plastic film: Thermal, mechanical, and degradation study.
34731804	2	67	theme	de	313:314	arg1	plasticizer					372:382	plasticizer	372:382	plasticizer at different weight ratio and weight percent, respectively	372:441	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	2	67	theme	de	313:314	arg1	NDC					322:324	NDC	322:324	NDC	322:324	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
34731804	2	67	theme	de	313:314	arg1	coco					316:319	Corn starch (CS)/nata de coco	291:319	Corn starch (CS)/nata de coco (NDC)	291:325	Corn starch (CS)/nata de coco (NDC) were hybridized with addition of glycerin as plasticizer at different weight ratio and weight percent, respectively.
32645579	8	0	theme	BPA	1884:1886	arg1	efficiency					1896:1905	BPA removal efficiency	1884:1905	BPA removal efficiency in secondary effluent after four 3-h cycles	1884:1949	Photocatalytic treatment using CDP-TiO2 only showed a small decrease in BPA removal efficiency in secondary effluent after four 3-h cycles, from 80.2% to 71.7%.
32645579	6	1	theme	adsorption	1468:1477	arg1	capacity					1479:1486	a BPA adsorption capacity	1462:1486	a BPA adsorption capacity of 36.9 ± 1.0 mg g-1	1462:1507	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	1	2	contain	has	194:196	arg1	treatment					184:192	Photocatalytic water treatment	163:192	Photocatalytic water treatment	163:192	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	1	2	contain	has	194:196	arg2	potential					210:218	significant potential	198:218	significant potential to disinfect and degrade recalcitrant organic pollutants	198:275	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	10	3	theme	CDP-TiO2	2083:2090	arg1	microspheres					2092:2103	the CDP-TiO2 microspheres	2079:2103	the CDP-TiO2 microspheres	2079:2103	Altogether, the CDP-TiO2 microspheres represent promising materials for potential use in photocatalytic water treatment.
32645579	10	4	from	use	2149:2151	arg1	treatment					2177:2185	photocatalytic water treatment	2156:2185	photocatalytic water treatment	2156:2185	Altogether, the CDP-TiO2 microspheres represent promising materials for potential use in photocatalytic water treatment.
32645579	3	5	theme	CD	730:731	arg1	polymer					733:739	an ROS-resistant fluorinated CD polymer	701:739	an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment	701:880	Here, we report an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment.
32645579	3	5	theme	CD	730:731	arg1	CDP					742:744	CDP	742:744	CDP	742:744	Here, we report an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment.
32645579	8	6	theme	secondary	1910:1918	arg1	effluent					1920:1927	secondary effluent	1910:1927	secondary effluent after four 3-h cycles	1910:1949	Photocatalytic treatment using CDP-TiO2 only showed a small decrease in BPA removal efficiency in secondary effluent after four 3-h cycles, from 80.2% to 71.7%.
32645579	0	7	theme	TiO2	0:3	arg1	microspheres					5:16	TiO2 microspheres	0:16	TiO2 microspheres with cross-linked cyclodextrin coating	0:55	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	7	8	theme	DI	1685:1686	arg1	water					1688:1692	DI water	1685:1692	DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1)	1685:1745	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	2	9	theme	photocatalyst	565:577	arg1	surface					579:585	the photocatalyst surface	561:585	the photocatalyst surface	561:585	Organic coatings such as cyclodextrin (CD) can adsorb target contaminants and bring them close to the photocatalyst surface to enhance ROS utilization efficiency, but the coatings themselves are susceptible to ROS attack.
32645579	8	10	theme	3-h	1940:1942	arg1	cycles					1944:1949	four 3-h cycles	1935:1949	four 3-h cycles	1935:1949	Photocatalytic treatment using CDP-TiO2 only showed a small decrease in BPA removal efficiency in secondary effluent after four 3-h cycles, from 80.2% to 71.7%.
32645579	1	11	contain	have	344:347	arg2	efficiency					361:370	poor energy efficiency	349:370	poor energy efficiency	349:370	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	1	11	contain	have	344:347	arg1	approaches					333:342	current approaches	325:342	current approaches	325:342	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	6	12	theme	CD-coated	1545:1553	arg1	TiO2					1555:1558	CD-coated TiO2	1545:1558	CD-coated TiO2 (CD-TiO2)	1545:1568	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	6	12	theme	CD-coated	1545:1553	arg1	CD-TiO2					1561:1567	CD-TiO2	1561:1567	CD-TiO2	1561:1567	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	7	13	theme	use	1678:1680	arg1	1000 h					1659:1664	1000 h	1659:1664	1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1)	1659:1745	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	4	14	theme	condensation	911:922	arg1	polymerization					924:937	condensation polymerization	911:937	condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile	911:989	We produced the CDP through condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile, resulting in a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption.
32645579	7	15	from	water	1688:1692	arg1	1000 h					1659:1664	1000 h	1659:1664	1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1)	1659:1745	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	1	16	theme	reactive	432:439	arg1	ROS					457:459	ROS	457:459	ROS	457:459	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	1	16	theme	reactive	432:439	arg1	species					448:454	photo-generated reactive oxygen species	416:454	photo-generated reactive oxygen species (ROS)	416:460	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	1	17	theme	organic	258:264	arg1	pollutants					266:275	recalcitrant organic pollutants	245:275	recalcitrant organic pollutants	245:275	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	2	18	theme	ROS	598:600	arg1	efficiency					614:623	ROS utilization efficiency	598:623	ROS utilization efficiency	598:623	Organic coatings such as cyclodextrin (CD) can adsorb target contaminants and bring them close to the photocatalyst surface to enhance ROS utilization efficiency, but the coatings themselves are susceptible to ROS attack.
32645579	0	19	from	stability	74:82	arg1	effluent					153:160	secondary effluent	143:160	secondary effluent	143:160	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	1	20	theme	species	448:454	arg1	utilization					401:411	inefficient utilization	389:411	inefficient utilization of photo-generated reactive oxygen species (ROS)	389:460	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	7	21	theme	organic	1766:1772	arg1	carbon					1774:1779	organic carbon	1766:1779	organic carbon	1766:1779	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	10	22	theme	potential	2139:2147	arg1	use					2149:2151	potential use	2139:2151	potential use in photocatalytic water treatment	2139:2185	Altogether, the CDP-TiO2 microspheres represent promising materials for potential use in photocatalytic water treatment.
32645579	7	23	theme	photoactivity	1634:1646	arg1	loss					1648:1651	minimal photoactivity loss	1626:1651	minimal photoactivity loss	1626:1651	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	2	24	theme	target	517:522	arg1	contaminants					524:535	target contaminants	517:535	target contaminants	517:535	Organic coatings such as cyclodextrin (CD) can adsorb target contaminants and bring them close to the photocatalyst surface to enhance ROS utilization efficiency, but the coatings themselves are susceptible to ROS attack.
32645579	0	25	from	degradation	113:123	arg1	effluent					153:160	secondary effluent	143:160	secondary effluent	143:160	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	3	26	theme	trap	852:855	arg1	treatment					872:880	"trap and zap" water treatment	851:880	"trap and zap" water treatment	851:880	Here, we report an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment.
32645579	6	27	theme	bare	1596:1599	arg1	TiO2					1601:1604	bare TiO2	1596:1604	bare TiO2	1596:1604	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	1	28	theme	water	178:182	arg1	treatment					184:192	Photocatalytic water treatment	163:192	Photocatalytic water treatment	163:192	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	3	29	theme	"	864:864	arg1	treatment					872:880	"trap and zap" water treatment	851:880	"trap and zap" water treatment	851:880	Here, we report an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment.
32645579	7	30	dep	irradiation	1704:1714	arg1	365 nm					1717:1722	365 nm	1717:1722	365 nm	1717:1722	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	7	30	dep	irradiation	1704:1714	arg1	3.83 × 10-6 E L-1s-1					1725:1744	3.83 × 10-6 E L-1s-1	1725:1744	3.83 × 10-6 E L-1s-1	1725:1744	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	0	31	theme	sustained	88:96	arg1	degradation					113:123	sustained photocatalytic degradation	88:123	sustained photocatalytic degradation of bisphenol A in secondary effluent	88:160	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	2	32	theme	ROS	673:675	arg1	attack					677:682	ROS attack	673:682	ROS attack	673:682	Organic coatings such as cyclodextrin (CD) can adsorb target contaminants and bring them close to the photocatalyst surface to enhance ROS utilization efficiency, but the coatings themselves are susceptible to ROS attack.
32645579	6	33	theme	CDP	1398:1400	arg1	%					1407:1407	5%	1406:1407	5%	1406:1407	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	6	33	theme	CDP	1398:1400	arg1	content					1387:1393	The optimum content	1375:1393	The optimum content of CDP	1375:1400	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	0	34	theme	bisphenol	128:136	arg1	A					138:138	bisphenol A	128:138	bisphenol A	128:138	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	1	35	theme	inefficient	389:399	arg1	utilization					401:411	inefficient utilization	389:411	inefficient utilization of photo-generated reactive oxygen species (ROS)	389:460	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	6	36	theme	optimal	1429:1435	arg1	composition					1446:1456	this optimal CDP-TiO2 composition	1424:1456	this optimal CDP-TiO2 composition	1424:1456	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	8	37	theme	small	1866:1870	arg1	decrease					1872:1879	a small decrease	1864:1879	a small decrease in BPA removal efficiency in secondary effluent after four 3-h cycles	1864:1949	Photocatalytic treatment using CDP-TiO2 only showed a small decrease in BPA removal efficiency in secondary effluent after four 3-h cycles, from 80.2% to 71.7%.
32645579	4	38	theme	CD	1038:1039	arg1	stable					1064:1069	stable	1064:1069	stable	1064:1069	We produced the CDP through condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile, resulting in a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption.
32645579	4	38	theme	CD	1038:1039	arg1	film					1041:1044	a cross-linked, covalently bound CD film	1005:1044	a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption	1005:1116	We produced the CDP through condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile, resulting in a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption.
32645579	4	39	link	cross-linked	1007:1018	arg1	stable					1064:1069	stable	1064:1069	stable	1064:1069	We produced the CDP through condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile, resulting in a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption.
32645579	4	39	link	cross-linked	1007:1018	arg1	film					1041:1044	a cross-linked, covalently bound CD film	1005:1044	a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption	1005:1116	We produced the CDP through condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile, resulting in a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption.
32645579	1	40	from	utilization	401:411	arg1	part					380:383	part	380:383	part	380:383	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	7	41	theme	UVA	1700:1702	arg1	irradiation					1704:1714	UVA irradiation	1700:1714	UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1)	1700:1745	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	2	42	theme	Organic	463:469	arg1	coatings					471:478	Organic coatings	463:478	Organic coatings such as cyclodextrin (CD)	463:504	Organic coatings such as cyclodextrin (CD) can adsorb target contaminants and bring them close to the photocatalyst surface to enhance ROS utilization efficiency, but the coatings themselves are susceptible to ROS attack.
32645579	2	42	theme	Organic	463:469	arg1	cyclodextrin					488:499	cyclodextrin	488:499	cyclodextrin (CD)	488:504	Organic coatings such as cyclodextrin (CD) can adsorb target contaminants and bring them close to the photocatalyst surface to enhance ROS utilization efficiency, but the coatings themselves are susceptible to ROS attack.
32645579	8	43	from	efficiency	1896:1905	arg1	effluent					1920:1927	secondary effluent	1910:1927	secondary effluent after four 3-h cycles	1910:1949	Photocatalytic treatment using CDP-TiO2 only showed a small decrease in BPA removal efficiency in secondary effluent after four 3-h cycles, from 80.2% to 71.7%.
32645579	6	44	theme	CDP-TiO2	1437:1444	arg1	composition					1446:1456	this optimal CDP-TiO2 composition	1424:1456	this optimal CDP-TiO2 composition	1424:1456	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	1	45	theme	current	325:331	arg1	approaches					333:342	current approaches	325:342	current approaches	325:342	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	4	46	theme	cross-linked	1007:1018	arg1	stable					1064:1069	stable	1064:1069	stable	1064:1069	We produced the CDP through condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile, resulting in a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption.
32645579	4	46	theme	cross-linked	1007:1018	arg1	film					1041:1044	a cross-linked, covalently bound CD film	1005:1044	a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption	1005:1116	We produced the CDP through condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile, resulting in a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption.
32645579	5	47	theme	photocatalytic	1347:1360	arg1	degradation					1362:1372	photocatalytic degradation	1347:1372	photocatalytic degradation	1347:1372	We optimized the coating thickness on TiO2 microspheres to improve the efficiency of contaminant degradation, and found that increasing the CDP content enhanced BPA adsorption but also occluded photocatalytic sites and hindered photocatalytic degradation.
32645579	0	48	theme	cyclodextrin	36:47	arg1	coating					49:55	cross-linked cyclodextrin coating	23:55	cross-linked cyclodextrin coating	23:55	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	5	49	theme	TiO2	1157:1160	arg1	microspheres					1162:1173	TiO2 microspheres	1157:1173	TiO2 microspheres	1157:1173	We optimized the coating thickness on TiO2 microspheres to improve the efficiency of contaminant degradation, and found that increasing the CDP content enhanced BPA adsorption but also occluded photocatalytic sites and hindered photocatalytic degradation.
32645579	10	50	theme	water	2171:2175	arg1	treatment					2177:2185	photocatalytic water treatment	2156:2185	photocatalytic water treatment	2156:2185	Altogether, the CDP-TiO2 microspheres represent promising materials for potential use in photocatalytic water treatment.
32645579	5	51	theme	photocatalytic	1313:1326	arg1	sites					1328:1332	occluded photocatalytic sites	1304:1332	BPA adsorption but also occluded photocatalytic sites	1280:1332	We optimized the coating thickness on TiO2 microspheres to improve the efficiency of contaminant degradation, and found that increasing the CDP content enhanced BPA adsorption but also occluded photocatalytic sites and hindered photocatalytic degradation.
32645579	1	52	theme	energy	354:359	arg1	efficiency					361:370	poor energy efficiency	349:370	poor energy efficiency	349:370	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	6	53	contain	had	1458:1460	arg1	composition					1446:1456	this optimal CDP-TiO2 composition	1424:1456	this optimal CDP-TiO2 composition	1424:1456	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	6	53	contain	had	1458:1460	arg2	capacity					1479:1486	a BPA adsorption capacity	1462:1486	a BPA adsorption capacity of 36.9 ± 1.0 mg g-1	1462:1507	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	4	54	theme	prior	1076:1080	arg1	approaches					1082:1091	prior approaches	1076:1091	prior approaches involving physi-sorption	1076:1116	We produced the CDP through condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile, resulting in a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption.
32645579	6	55	theme	36.9 ± 1.0 mg g-1	1491:1507	arg1	capacity					1479:1486	a BPA adsorption capacity	1462:1486	a BPA adsorption capacity of 36.9 ± 1.0 mg g-1	1462:1507	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	3	56	theme	fluorinated	718:728	arg1	polymer					733:739	an ROS-resistant fluorinated CD polymer	701:739	an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment	701:880	Here, we report an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment.
32645579	3	56	theme	fluorinated	718:728	arg1	CDP					742:744	CDP	742:744	CDP	742:744	Here, we report an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment.
32645579	8	57	theme	removal	1888:1894	arg1	efficiency					1896:1905	BPA removal efficiency	1884:1905	BPA removal efficiency in secondary effluent after four 3-h cycles	1884:1949	Photocatalytic treatment using CDP-TiO2 only showed a small decrease in BPA removal efficiency in secondary effluent after four 3-h cycles, from 80.2% to 71.7%.
32645579	5	58	theme	degradation	1216:1226	arg1	efficiency					1190:1199	the efficiency	1186:1199	the efficiency of contaminant degradation	1186:1226	We optimized the coating thickness on TiO2 microspheres to improve the efficiency of contaminant degradation, and found that increasing the CDP content enhanced BPA adsorption but also occluded photocatalytic sites and hindered photocatalytic degradation.
32645579	0	59	link	cross-linked	23:34	arg1	coating					49:55	cross-linked cyclodextrin coating	23:55	cross-linked cyclodextrin coating	23:55	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	4	60	dep	cross-linked	1007:1018	arg1	bound					1032:1036	bound	1032:1036	bound	1032:1036	We produced the CDP through condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile, resulting in a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption.
32645579	6	61	theme	BPA	1464:1466	arg1	capacity					1479:1486	a BPA adsorption capacity	1462:1486	a BPA adsorption capacity of 36.9 ± 1.0 mg g-1	1462:1507	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	2	62	theme	utilization	602:612	arg1	efficiency					614:623	ROS utilization efficiency	598:623	ROS utilization efficiency	598:623	Organic coatings such as cyclodextrin (CD) can adsorb target contaminants and bring them close to the photocatalyst surface to enhance ROS utilization efficiency, but the coatings themselves are susceptible to ROS attack.
32645579	1	63	theme	significant	198:208	arg1	potential					210:218	significant potential	198:218	significant potential to disinfect and degrade recalcitrant organic pollutants	198:275	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	8	64	dep	%	1970:1970	arg1	to					1963:1964	to	1963:1964	to	1963:1964	Photocatalytic treatment using CDP-TiO2 only showed a small decrease in BPA removal efficiency in secondary effluent after four 3-h cycles, from 80.2% to 71.7%.
32645579	6	65	theme	optimum	1379:1385	arg1	%					1407:1407	5%	1406:1407	5%	1406:1407	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	6	65	theme	optimum	1379:1385	arg1	content					1387:1393	The optimum content	1375:1393	The optimum content of CDP	1375:1400	The optimum content of CDP was 5% by weight, and this optimal CDP-TiO2 composition had a BPA adsorption capacity of 36.9 ± 1.0 mg g-1 compared with 24.1 ± 1.1 mg g-1 for CD-coated TiO2 (CD-TiO2) and 21.9 ± 1.5 mg g-1 for bare TiO2.
32645579	1	66	dep	potential	210:218	arg1	degrade					237:243	degrade	237:243	degrade recalcitrant organic pollutants	237:275	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	1	66	dep	potential	210:218	arg1	disinfect					223:231	disinfect	223:231	disinfect	223:231	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	7	67	theme	repeated	1669:1676	arg1	use					1678:1680	repeated use	1669:1680	repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1)	1669:1745	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	10	68	theme	promising	2115:2123	arg1	materials					2125:2133	promising materials	2115:2133	promising materials for potential use in photocatalytic water treatment	2115:2185	Altogether, the CDP-TiO2 microspheres represent promising materials for potential use in photocatalytic water treatment.
32645579	1	69	theme	photo-generated	416:430	arg1	ROS					457:459	ROS	457:459	ROS	457:459	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	1	69	theme	photo-generated	416:430	arg1	species					448:454	photo-generated reactive oxygen species	416:454	photo-generated reactive oxygen species (ROS)	416:460	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	1	70	theme	recalcitrant	245:256	arg1	pollutants					266:275	recalcitrant organic pollutants	245:275	recalcitrant organic pollutants	245:275	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	10	71	theme	photocatalytic	2156:2169	arg1	treatment					2177:2185	photocatalytic water treatment	2156:2185	photocatalytic water treatment	2156:2185	Altogether, the CDP-TiO2 microspheres represent promising materials for potential use in photocatalytic water treatment.
32645579	8	72	theme	%	1961:1961	arg1	%					1970:1970	80.2% to 71.7%	1957:1970	80.2% to 71.7%	1957:1970	Photocatalytic treatment using CDP-TiO2 only showed a small decrease in BPA removal efficiency in secondary effluent after four 3-h cycles, from 80.2% to 71.7%.
32645579	1	73	theme	oxygen	441:446	arg1	ROS					457:459	ROS	457:459	ROS	457:459	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	1	73	theme	oxygen	441:446	arg1	species					448:454	photo-generated reactive oxygen species	416:454	photo-generated reactive oxygen species (ROS)	416:460	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	0	74	theme	secondary	143:151	arg1	effluent					153:160	secondary effluent	143:160	secondary effluent	143:160	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	7	75	theme	carbon	1774:1779	arg1	release					1755:1761	no release	1752:1761	no release of organic carbon from the coating	1752:1796	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	7	76	theme	minimal	1626:1632	arg1	loss					1648:1651	minimal photoactivity loss	1626:1651	minimal photoactivity loss	1626:1651	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	5	77	theme	occluded	1304:1311	arg1	sites					1328:1332	occluded photocatalytic sites	1304:1332	BPA adsorption but also occluded photocatalytic sites	1280:1332	We optimized the coating thickness on TiO2 microspheres to improve the efficiency of contaminant degradation, and found that increasing the CDP content enhanced BPA adsorption but also occluded photocatalytic sites and hindered photocatalytic degradation.
32645579	1	78	theme	Photocatalytic	163:176	arg1	treatment					184:192	Photocatalytic water treatment	163:192	Photocatalytic water treatment	163:192	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	4	79	theme	tetrafluoroterephthalonitrile	961:989	arg1	polymerization					924:937	condensation polymerization	911:937	condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile	911:989	We produced the CDP through condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile, resulting in a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption.
32645579	8	80	from	decrease	1872:1879	arg1	efficiency					1896:1905	BPA removal efficiency	1884:1905	BPA removal efficiency in secondary effluent after four 3-h cycles	1884:1949	Photocatalytic treatment using CDP-TiO2 only showed a small decrease in BPA removal efficiency in secondary effluent after four 3-h cycles, from 80.2% to 71.7%.
32645579	0	81	theme	photocatalytic	98:111	arg1	degradation					113:123	sustained photocatalytic degradation	88:123	sustained photocatalytic degradation of bisphenol A in secondary effluent	88:160	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	5	82	theme	coating	1136:1142	arg1	thickness					1144:1152	the coating thickness	1132:1152	the coating thickness on TiO2 microspheres	1132:1173	We optimized the coating thickness on TiO2 microspheres to improve the efficiency of contaminant degradation, and found that increasing the CDP content enhanced BPA adsorption but also occluded photocatalytic sites and hindered photocatalytic degradation.
32645579	8	83	theme	Photocatalytic	1812:1825	arg1	treatment					1827:1835	Photocatalytic treatment	1812:1835	Photocatalytic treatment using CDP-TiO2	1812:1850	Photocatalytic treatment using CDP-TiO2 only showed a small decrease in BPA removal efficiency in secondary effluent after four 3-h cycles, from 80.2% to 71.7%.
32645579	3	84	theme	water	866:870	arg1	treatment					872:880	"trap and zap" water treatment	851:880	"trap and zap" water treatment	851:880	Here, we report an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment.
32645579	5	85	theme	BPA	1280:1282	arg1	adsorption					1284:1293	BPA adsorption	1280:1293	BPA adsorption but also occluded photocatalytic sites	1280:1332	We optimized the coating thickness on TiO2 microspheres to improve the efficiency of contaminant degradation, and found that increasing the CDP content enhanced BPA adsorption but also occluded photocatalytic sites and hindered photocatalytic degradation.
32645579	3	86	theme	efficient	828:836	arg1	material					838:845	a more efficient material	821:845	a more efficient material for "trap and zap" water treatment	821:880	Here, we report an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment.
32645579	7	87	from	1000 h	1659:1664	arg1	water					1688:1692	DI water	1685:1692	DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1)	1685:1745	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	3	88	theme	zap	861:863	arg1	treatment					872:880	"trap and zap" water treatment	851:880	"trap and zap" water treatment	851:880	Here, we report an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment.
32645579	0	89	theme	A	138:138	arg1	stability					74:82	improved stability	65:82	improved stability	65:82	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	0	89	theme	A	138:138	arg1	degradation					113:123	sustained photocatalytic degradation	88:123	sustained photocatalytic degradation of bisphenol A in secondary effluent	88:160	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	4	90	theme	β-cyclodextrin	942:955	arg1	polymerization					924:937	condensation polymerization	911:937	condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile	911:989	We produced the CDP through condensation polymerization of β-cyclodextrin and tetrafluoroterephthalonitrile, resulting in a cross-linked, covalently bound CD film that is much more stable than prior approaches involving physi-sorption.
32645579	0	91	theme	cross-linked	23:34	arg1	coating					49:55	cross-linked cyclodextrin coating	23:55	cross-linked cyclodextrin coating	23:55	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	9	92	theme	BPA	2033:2035	arg1	BPA					2033:2035	BPA	2033:2035	BPA	2033:2035	In contrast, CD-TiO2 and P25 removed only 29.8% and 6.2% of BPA after 4 cycles, respectively.
32645579	9	92	theme	BPA	2033:2035	arg1	%					2019:2019	only 29.8%	2010:2019	only 29.8%	2010:2019	In contrast, CD-TiO2 and P25 removed only 29.8% and 6.2% of BPA after 4 cycles, respectively.
32645579	9	92	theme	BPA	2033:2035	arg1	%					2028:2028	6.2%	2025:2028	6.2% of BPA	2025:2035	In contrast, CD-TiO2 and P25 removed only 29.8% and 6.2% of BPA after 4 cycles, respectively.
32645579	5	93	from	thickness	1144:1152	arg1	microspheres					1162:1173	TiO2 microspheres	1157:1173	TiO2 microspheres	1157:1173	We optimized the coating thickness on TiO2 microspheres to improve the efficiency of contaminant degradation, and found that increasing the CDP content enhanced BPA adsorption but also occluded photocatalytic sites and hindered photocatalytic degradation.
32645579	5	94	theme	contaminant	1204:1214	arg1	degradation					1216:1226	contaminant degradation	1204:1226	contaminant degradation	1204:1226	We optimized the coating thickness on TiO2 microspheres to improve the efficiency of contaminant degradation, and found that increasing the CDP content enhanced BPA adsorption but also occluded photocatalytic sites and hindered photocatalytic degradation.
32645579	0	95	theme	improved	65:72	arg1	stability					74:82	improved stability	65:82	improved stability	65:82	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	1	96	theme	poor	349:352	arg1	efficiency					361:370	poor energy efficiency	349:370	poor energy efficiency	349:370	Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS).
32645579	7	97	from	use	1678:1680	arg1	water					1688:1692	DI water	1685:1692	DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1)	1685:1745	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	0	98	with	microspheres	5:16	arg1	coating					49:55	cross-linked cyclodextrin coating	23:55	cross-linked cyclodextrin coating	23:55	TiO2 microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.
32645579	7	99	from	coating	1790:1796	arg1	release					1755:1761	no release	1752:1761	no release of organic carbon from the coating	1752:1796	CDP-TiO2 exhibited minimal photoactivity loss after 1000 h of repeated use in DI water under UVA irradiation (365 nm, 3.83 × 10-6 E L-1s-1), and no release of organic carbon from the coating was detected.
32645579	3	100	theme	ROS-resistant	704:716	arg1	polymer					733:739	an ROS-resistant fluorinated CD polymer	701:739	an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment	701:880	Here, we report an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment.
32645579	3	100	theme	ROS-resistant	704:716	arg1	CDP					742:744	CDP	742:744	CDP	742:744	Here, we report an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment.
32645579	5	101	theme	CDP	1259:1261	arg1	content					1263:1269	the CDP content	1255:1269	the CDP content	1255:1269	We optimized the coating thickness on TiO2 microspheres to improve the efficiency of contaminant degradation, and found that increasing the CDP content enhanced BPA adsorption but also occluded photocatalytic sites and hindered photocatalytic degradation.
33453408	8	0	theme	placenta-derived	1225:1240	arg1	hydrogel					1257:1264	placenta-derived dECM (PL-dECM) hydrogel	1225:1264	placenta-derived dECM (PL-dECM) hydrogel	1225:1264	Our results revealed that placenta-derived dECM (PL-dECM) hydrogel has higher contents of chondroitin sulfate (CS) and heparan sulfate (HS).
33453408	3	1	theme	perinatal	556:564	arg1	tissues					566:572	perinatal tissues	556:572	perinatal tissues	556:572	However, the dECM is organ specific, and the glycosaminoglycanomics of dECMs from perinatal tissues and the regulatory function of GAGs have been poorly investigated.
33453408	9	2	theme	wound	1477:1481	arg1	healing					1483:1489	the skin wound healing	1468:1489	the skin wound healing model	1468:1495	In addition, molecular imaging showed that the PL-dECM hydrogel exerted the best anti-inflammatory and proangiogenic effects in the skin wound healing model.
33453408	6	3	theme	perinatal	895:903	arg1	tissues					905:911	perinatal tissues	895:911	perinatal tissues	895:911	Hydrogels of dECM derived from perinatal tissues were generated, and glycosaminoglycanomics analysis was employed to identify the cues that promote tissue repair and regeneration in a murine cutaneous wound-healing model.
33453408	6	4	attach	derived	882:888	arg2	dECM					877:880	dECM	877:880	dECM derived from perinatal tissues	877:911	Hydrogels of dECM derived from perinatal tissues were generated, and glycosaminoglycanomics analysis was employed to identify the cues that promote tissue repair and regeneration in a murine cutaneous wound-healing model.
33453408	6	4	attach	derived	882:888	arg1	tissues					905:911	perinatal tissues	895:911	perinatal tissues	895:911	Hydrogels of dECM derived from perinatal tissues were generated, and glycosaminoglycanomics analysis was employed to identify the cues that promote tissue repair and regeneration in a murine cutaneous wound-healing model.
33453408	7	5	theme	mass	1144:1147	arg1	spectrometry					1149:1160	highly sensitive liquid chromatography-tandem mass spectrometry	1098:1160	highly sensitive liquid chromatography-tandem mass spectrometry	1098:1160	We utilized highly sensitive liquid chromatography-tandem mass spectrometry for glycosaminoglycanomics analysis.
33453408	3	6	theme	dECMs	545:549	arg1	function					593:600	the regulatory function	578:600	the regulatory function of GAGs	578:608	However, the dECM is organ specific, and the glycosaminoglycanomics of dECMs from perinatal tissues and the regulatory function of GAGs have been poorly investigated.
33453408	3	6	theme	dECMs	545:549	arg1	glycosaminoglycanomics					519:540	the glycosaminoglycanomics	515:540	the glycosaminoglycanomics of dECMs from perinatal tissues	515:572	However, the dECM is organ specific, and the glycosaminoglycanomics of dECMs from perinatal tissues and the regulatory function of GAGs have been poorly investigated.
33453408	7	7	theme	liquid	1115:1120	arg1	spectrometry					1149:1160	highly sensitive liquid chromatography-tandem mass spectrometry	1098:1160	highly sensitive liquid chromatography-tandem mass spectrometry	1098:1160	We utilized highly sensitive liquid chromatography-tandem mass spectrometry for glycosaminoglycanomics analysis.
33453408	3	8	theme	regulatory	582:591	arg1	function					593:600	the regulatory function	578:600	the regulatory function of GAGs	578:608	However, the dECM is organ specific, and the glycosaminoglycanomics of dECMs from perinatal tissues and the regulatory function of GAGs have been poorly investigated.
33453408	10	9	with	HS	1613:1614	arg1	HS-6S					1638:1642	HS-6S	1638:1642	HS-6S	1638:1642	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	10	9	with	HS	1613:1614	arg1	group					1631:1635	6-O-sulfo group	1621:1635	6-O-sulfo group (HS-6S)	1621:1643	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	8	10	theme	heparan	1318:1324	arg1	HS					1335:1336	HS	1335:1336	HS	1335:1336	Our results revealed that placenta-derived dECM (PL-dECM) hydrogel has higher contents of chondroitin sulfate (CS) and heparan sulfate (HS).
33453408	8	10	theme	heparan	1318:1324	arg1	sulfate					1326:1332	heparan sulfate	1318:1332	heparan sulfate (HS)	1318:1337	Our results revealed that placenta-derived dECM (PL-dECM) hydrogel has higher contents of chondroitin sulfate (CS) and heparan sulfate (HS).
33453408	10	11	theme	6-O-sulfo	1621:1629	arg1	HS-6S					1638:1642	HS-6S	1638:1642	HS-6S	1638:1642	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	10	11	theme	6-O-sulfo	1621:1629	arg1	group					1631:1635	6-O-sulfo group	1621:1635	6-O-sulfo group (HS-6S)	1621:1643	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	5	12	theme	GAGs	858:861	arg1	composition					843:853	the detailed composition	830:853	the detailed composition of GAGs	830:861	We hypothesized that the therapeutic effects of dECMs are related to the detailed composition of GAGs.
33453408	8	13	theme	chondroitin	1289:1299	arg1	CS					1310:1311	CS	1310:1311	CS	1310:1311	Our results revealed that placenta-derived dECM (PL-dECM) hydrogel has higher contents of chondroitin sulfate (CS) and heparan sulfate (HS).
33453408	8	13	theme	chondroitin	1289:1299	arg1	sulfate					1301:1307	chondroitin sulfate	1289:1307	chondroitin sulfate (CS)	1289:1312	Our results revealed that placenta-derived dECM (PL-dECM) hydrogel has higher contents of chondroitin sulfate (CS) and heparan sulfate (HS).
33453408	10	14	with	CS	1542:1543	arg1	CS-6S					1567:1571	CS-6S	1567:1571	CS-6S	1567:1571	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	10	14	with	CS	1542:1543	arg1	group					1560:1564	6-O-sulfo group	1550:1564	6-O-sulfo group (CS-6S)	1550:1572	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	6	15	theme	glycosaminoglycanomics	933:954	arg1	analysis					956:963	glycosaminoglycanomics analysis	933:963	glycosaminoglycanomics analysis	933:963	Hydrogels of dECM derived from perinatal tissues were generated, and glycosaminoglycanomics analysis was employed to identify the cues that promote tissue repair and regeneration in a murine cutaneous wound-healing model.
33453408	8	16	contain	has	1266:1268	arg1	hydrogel					1257:1264	placenta-derived dECM (PL-dECM) hydrogel	1225:1264	placenta-derived dECM (PL-dECM) hydrogel	1225:1264	Our results revealed that placenta-derived dECM (PL-dECM) hydrogel has higher contents of chondroitin sulfate (CS) and heparan sulfate (HS).
33453408	8	16	contain	has	1266:1268	arg2	contents					1277:1284	higher contents	1270:1284	higher contents of chondroitin sulfate (CS) and heparan sulfate (HS)	1270:1337	Our results revealed that placenta-derived dECM (PL-dECM) hydrogel has higher contents of chondroitin sulfate (CS) and heparan sulfate (HS).
33453408	11	17	from	roles	1733:1737	arg1	dECMs					1775:1779	perinatal tissue-derived dECMs	1750:1779	perinatal tissue-derived dECMs	1750:1779	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	11	18	theme	drug	1982:1985	arg1	delivery					1987:1994	drug delivery	1982:1994	drug delivery	1982:1994	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	4	19	theme	dECMs	698:702	arg1	glycosaminoglycanomics					672:693	the glycosaminoglycanomics	668:693	the glycosaminoglycanomics of dECMs from the placenta, umbilical cord and amniotic membrane	668:758	In this study, we explored the glycosaminoglycanomics of dECMs from the placenta, umbilical cord and amniotic membrane.
33453408	11	20	theme	perinatal	1750:1758	arg1	dECMs					1775:1779	perinatal tissue-derived dECMs	1750:1779	perinatal tissue-derived dECMs	1750:1779	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	8	21	link	placenta-derived	1225:1240	arg1	hydrogel					1257:1264	placenta-derived dECM (PL-dECM) hydrogel	1225:1264	placenta-derived dECM (PL-dECM) hydrogel	1225:1264	Our results revealed that placenta-derived dECM (PL-dECM) hydrogel has higher contents of chondroitin sulfate (CS) and heparan sulfate (HS).
33453408	10	22	theme	Further	1498:1504	arg1	analyses					1515:1522	Further in vitro analyses	1498:1522	Further in vitro analyses	1498:1522	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	0	23	theme	cutaneous	89:97	arg1	healing					105:111	cutaneous wound healing	89:111	cutaneous wound healing	89:111	Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing.
33453408	6	24	theme	tissue	1012:1017	arg1	repair					1019:1024	tissue repair	1012:1024	tissue repair	1012:1024	Hydrogels of dECM derived from perinatal tissues were generated, and glycosaminoglycanomics analysis was employed to identify the cues that promote tissue repair and regeneration in a murine cutaneous wound-healing model.
33453408	9	25	theme	molecular	1353:1361	arg1	imaging					1363:1369	molecular imaging	1353:1369	molecular imaging	1353:1369	In addition, molecular imaging showed that the PL-dECM hydrogel exerted the best anti-inflammatory and proangiogenic effects in the skin wound healing model.
33453408	10	26	dep	in	1506:1507	arg1	vitro					1509:1513	vitro	1509:1513	vitro	1509:1513	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	9	27	theme	PL-dECM	1387:1393	arg1	hydrogel					1395:1402	the PL-dECM hydrogel	1383:1402	the PL-dECM hydrogel	1383:1402	In addition, molecular imaging showed that the PL-dECM hydrogel exerted the best anti-inflammatory and proangiogenic effects in the skin wound healing model.
33453408	11	28	link	tissue-derived	1760:1773	arg1	dECMs					1775:1779	perinatal tissue-derived dECMs	1750:1779	perinatal tissue-derived dECMs	1750:1779	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	4	29	theme	amniotic	742:749	arg1	membrane					751:758	amniotic membrane	742:758	amniotic membrane	742:758	In this study, we explored the glycosaminoglycanomics of dECMs from the placenta, umbilical cord and amniotic membrane.
33453408	11	30	theme	attractive	1934:1943	arg1	hydrogel					1919:1926	6-sulfated GAG-enriched placental dECM hydrogel	1880:1926	6-sulfated GAG-enriched placental dECM hydrogel	1880:1926	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	11	30	theme	attractive	1934:1943	arg1	candidate					1945:1953	an attractive candidate	1931:1953	an attractive candidate for tissue engineering and drug delivery	1931:1994	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	0	31	theme	Sulfated	0:7	arg1	glycosaminoglycans					9:26	Sulfated glycosaminoglycans	0:26	Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing.	0:112	Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing.
33453408	1	32	theme	alternative	286:296	arg1	attention					273:281	attention	273:281	attention	273:281	Perinatal-related tissues, such as the placenta, umbilical cord, and amniotic membrane, are generally discarded after delivery and are increasingly attracting attention as alternative sources for decellularized extracellular matrix (dECM) isolation.
33453408	1	32	theme	alternative	286:296	arg1	sources					298:304	alternative sources	286:304	alternative sources for decellularized extracellular matrix (dECM) isolation	286:361	Perinatal-related tissues, such as the placenta, umbilical cord, and amniotic membrane, are generally discarded after delivery and are increasingly attracting attention as alternative sources for decellularized extracellular matrix (dECM) isolation.
33453408	10	33	theme	6-O-sulfo	1550:1558	arg1	CS-6S					1567:1571	CS-6S	1567:1571	CS-6S	1567:1571	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	10	33	theme	6-O-sulfo	1550:1558	arg1	group					1560:1564	6-O-sulfo group	1550:1564	6-O-sulfo group (CS-6S)	1550:1572	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	2	34	theme	key	436:438	arg1	roles					440:444	key roles	436:444	key roles	436:444	Recent studies indicate that glycosaminoglycans (GAGs) in the dECM play key roles during tissue regeneration.
33453408	6	35	theme	dECM	877:880	arg1	Hydrogels					864:872	Hydrogels	864:872	Hydrogels of dECM derived from perinatal tissues	864:911	Hydrogels of dECM derived from perinatal tissues were generated, and glycosaminoglycanomics analysis was employed to identify the cues that promote tissue repair and regeneration in a murine cutaneous wound-healing model.
33453408	6	36	theme	wound-healing	1065:1077	arg1	model					1079:1083	a murine cutaneous wound-healing model	1046:1083	a murine cutaneous wound-healing model	1046:1083	Hydrogels of dECM derived from perinatal tissues were generated, and glycosaminoglycanomics analysis was employed to identify the cues that promote tissue repair and regeneration in a murine cutaneous wound-healing model.
33453408	11	37	theme	critical	1724:1731	arg1	roles					1733:1737	the critical roles	1720:1737	the critical roles of GAGs in perinatal tissue-derived dECMs	1720:1779	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	0	38	theme	placenta	46:53	arg1	matrix					55:60	decellularized placenta matrix	31:60	decellularized placenta matrix	31:60	Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing.
33453408	1	39	theme	extracellular	325:337	arg1	matrix					339:344	extracellular matrix	325:344	decellularized extracellular matrix (dECM) isolation	310:361	Perinatal-related tissues, such as the placenta, umbilical cord, and amniotic membrane, are generally discarded after delivery and are increasingly attracting attention as alternative sources for decellularized extracellular matrix (dECM) isolation.
33453408	1	39	theme	extracellular	325:337	arg1	dECM					347:350	dECM	347:350	dECM	347:350	Perinatal-related tissues, such as the placenta, umbilical cord, and amniotic membrane, are generally discarded after delivery and are increasingly attracting attention as alternative sources for decellularized extracellular matrix (dECM) isolation.
33453408	6	40	theme	murine	1048:1053	arg1	model					1079:1083	a murine cutaneous wound-healing model	1046:1083	a murine cutaneous wound-healing model	1046:1083	Hydrogels of dECM derived from perinatal tissues were generated, and glycosaminoglycanomics analysis was employed to identify the cues that promote tissue repair and regeneration in a murine cutaneous wound-healing model.
33453408	2	41	theme	Recent	364:369	arg1	studies					371:377	Recent studies	364:377	Recent studies	364:377	Recent studies indicate that glycosaminoglycans (GAGs) in the dECM play key roles during tissue regeneration.
33453408	5	42	theme	dECMs	809:813	arg1	related					819:825	related	819:825	related	819:825	We hypothesized that the therapeutic effects of dECMs are related to the detailed composition of GAGs.
33453408	5	42	theme	dECMs	809:813	arg1	effects					798:804	the therapeutic effects	782:804	the therapeutic effects of dECMs	782:813	We hypothesized that the therapeutic effects of dECMs are related to the detailed composition of GAGs.
33453408	9	43	theme	anti-inflammatory	1421:1437	arg1	effects					1457:1463	the best anti-inflammatory and proangiogenic effects	1412:1463	the best anti-inflammatory and proangiogenic effects	1412:1463	In addition, molecular imaging showed that the PL-dECM hydrogel exerted the best anti-inflammatory and proangiogenic effects in the skin wound healing model.
33453408	4	44	from	placenta	713:720	arg1	glycosaminoglycanomics					672:693	the glycosaminoglycanomics	668:693	the glycosaminoglycanomics of dECMs from the placenta, umbilical cord and amniotic membrane	668:758	In this study, we explored the glycosaminoglycanomics of dECMs from the placenta, umbilical cord and amniotic membrane.
33453408	9	45	theme	proangiogenic	1443:1455	arg1	effects					1457:1463	the best anti-inflammatory and proangiogenic effects	1412:1463	the best anti-inflammatory and proangiogenic effects	1412:1463	In addition, molecular imaging showed that the PL-dECM hydrogel exerted the best anti-inflammatory and proangiogenic effects in the skin wound healing model.
33453408	7	46	theme	glycosaminoglycanomics	1166:1187	arg1	analysis					1189:1196	glycosaminoglycanomics analysis	1166:1196	glycosaminoglycanomics analysis	1166:1196	We utilized highly sensitive liquid chromatography-tandem mass spectrometry for glycosaminoglycanomics analysis.
33453408	11	47	theme	dECM	1914:1917	arg1	hydrogel					1919:1926	6-sulfated GAG-enriched placental dECM hydrogel	1880:1926	6-sulfated GAG-enriched placental dECM hydrogel	1880:1926	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	11	47	theme	dECM	1914:1917	arg1	candidate					1945:1953	an attractive candidate	1931:1953	an attractive candidate for tissue engineering and drug delivery	1931:1994	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	9	48	theme	skin	1472:1475	arg1	healing					1483:1489	the skin wound healing	1468:1489	the skin wound healing model	1468:1495	In addition, molecular imaging showed that the PL-dECM hydrogel exerted the best anti-inflammatory and proangiogenic effects in the skin wound healing model.
33453408	11	49	theme	GAG-enriched	1891:1902	arg1	hydrogel					1919:1926	6-sulfated GAG-enriched placental dECM hydrogel	1880:1926	6-sulfated GAG-enriched placental dECM hydrogel	1880:1926	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	11	49	theme	GAG-enriched	1891:1902	arg1	candidate					1945:1953	an attractive candidate	1931:1953	an attractive candidate for tissue engineering and drug delivery	1931:1994	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	7	50	theme	chromatography-tandem	1122:1142	arg1	spectrometry					1149:1160	highly sensitive liquid chromatography-tandem mass spectrometry	1098:1160	highly sensitive liquid chromatography-tandem mass spectrometry	1098:1160	We utilized highly sensitive liquid chromatography-tandem mass spectrometry for glycosaminoglycanomics analysis.
33453408	3	51	from	glycosaminoglycanomics	519:540	arg1	tissues					566:572	perinatal tissues	556:572	perinatal tissues	556:572	However, the dECM is organ specific, and the glycosaminoglycanomics of dECMs from perinatal tissues and the regulatory function of GAGs have been poorly investigated.
33453408	9	52	theme	healing	1483:1489	arg1	model					1491:1495	the skin wound healing model	1468:1495	the skin wound healing model	1468:1495	In addition, molecular imaging showed that the PL-dECM hydrogel exerted the best anti-inflammatory and proangiogenic effects in the skin wound healing model.
33453408	8	53	theme	dECM	1242:1245	arg1	hydrogel					1257:1264	placenta-derived dECM (PL-dECM) hydrogel	1225:1264	placenta-derived dECM (PL-dECM) hydrogel	1225:1264	Our results revealed that placenta-derived dECM (PL-dECM) hydrogel has higher contents of chondroitin sulfate (CS) and heparan sulfate (HS).
33453408	8	54	theme	sulfate	1301:1307	arg1	contents					1277:1284	higher contents	1270:1284	higher contents of chondroitin sulfate (CS) and heparan sulfate (HS)	1270:1337	Our results revealed that placenta-derived dECM (PL-dECM) hydrogel has higher contents of chondroitin sulfate (CS) and heparan sulfate (HS).
33453408	7	55	theme	sensitive	1105:1113	arg1	spectrometry					1149:1160	highly sensitive liquid chromatography-tandem mass spectrometry	1098:1160	highly sensitive liquid chromatography-tandem mass spectrometry	1098:1160	We utilized highly sensitive liquid chromatography-tandem mass spectrometry for glycosaminoglycanomics analysis.
33453408	1	56	theme	amniotic	183:190	arg1	membrane					192:199	amniotic membrane	183:199	amniotic membrane	183:199	Perinatal-related tissues, such as the placenta, umbilical cord, and amniotic membrane, are generally discarded after delivery and are increasingly attracting attention as alternative sources for decellularized extracellular matrix (dECM) isolation.
33453408	8	57	theme	PL-dECM	1248:1254	arg1	hydrogel					1257:1264	placenta-derived dECM (PL-dECM) hydrogel	1225:1264	placenta-derived dECM (PL-dECM) hydrogel	1225:1264	Our results revealed that placenta-derived dECM (PL-dECM) hydrogel has higher contents of chondroitin sulfate (CS) and heparan sulfate (HS).
33453408	2	58	from	glycosaminoglycans	393:410	arg1	dECM					426:429	the dECM	422:429	the dECM	422:429	Recent studies indicate that glycosaminoglycans (GAGs) in the dECM play key roles during tissue regeneration.
33453408	5	59	theme	detailed	834:841	arg1	composition					843:853	the detailed composition	830:853	the detailed composition of GAGs	830:861	We hypothesized that the therapeutic effects of dECMs are related to the detailed composition of GAGs.
33453408	7	60	used	utilized	1089:1096	arg2	We					1086:1087	We	1086:1087	We	1086:1087	We utilized highly sensitive liquid chromatography-tandem mass spectrometry for glycosaminoglycanomics analysis.
33453408	10	61	theme	crucial	1653:1659	arg1	role					1661:1664	a crucial role	1651:1664	a crucial role	1651:1664	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	3	62	theme	GAGs	605:608	arg1	function					593:600	the regulatory function	578:600	the regulatory function of GAGs	578:608	However, the dECM is organ specific, and the glycosaminoglycanomics of dECMs from perinatal tissues and the regulatory function of GAGs have been poorly investigated.
33453408	3	62	theme	GAGs	605:608	arg1	glycosaminoglycanomics					519:540	the glycosaminoglycanomics	515:540	the glycosaminoglycanomics of dECMs from perinatal tissues	515:572	However, the dECM is organ specific, and the glycosaminoglycanomics of dECMs from perinatal tissues and the regulatory function of GAGs have been poorly investigated.
33453408	8	63	theme	higher	1270:1275	arg1	contents					1277:1284	higher contents	1270:1284	higher contents of chondroitin sulfate (CS) and heparan sulfate (HS)	1270:1337	Our results revealed that placenta-derived dECM (PL-dECM) hydrogel has higher contents of chondroitin sulfate (CS) and heparan sulfate (HS).
33453408	8	64	theme	sulfate	1326:1332	arg1	contents					1277:1284	higher contents	1270:1284	higher contents of chondroitin sulfate (CS) and heparan sulfate (HS)	1270:1337	Our results revealed that placenta-derived dECM (PL-dECM) hydrogel has higher contents of chondroitin sulfate (CS) and heparan sulfate (HS).
33453408	3	65	from	tissues	566:572	arg1	function					593:600	the regulatory function	578:600	the regulatory function of GAGs	578:608	However, the dECM is organ specific, and the glycosaminoglycanomics of dECMs from perinatal tissues and the regulatory function of GAGs have been poorly investigated.
33453408	3	65	from	tissues	566:572	arg1	dECMs					545:549	dECMs	545:549	dECMs from perinatal tissues	545:572	However, the dECM is organ specific, and the glycosaminoglycanomics of dECMs from perinatal tissues and the regulatory function of GAGs have been poorly investigated.
33453408	3	65	from	tissues	566:572	arg1	glycosaminoglycanomics					519:540	the glycosaminoglycanomics	515:540	the glycosaminoglycanomics of dECMs from perinatal tissues	515:572	However, the dECM is organ specific, and the glycosaminoglycanomics of dECMs from perinatal tissues and the regulatory function of GAGs have been poorly investigated.
33453408	4	66	theme	umbilical	723:731	arg1	cord					733:736	umbilical cord	723:736	umbilical cord	723:736	In this study, we explored the glycosaminoglycanomics of dECMs from the placenta, umbilical cord and amniotic membrane.
33453408	11	67	theme	tissue-derived	1760:1773	arg1	dECMs					1775:1779	perinatal tissue-derived dECMs	1750:1779	perinatal tissue-derived dECMs	1750:1779	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	0	68	theme	wound	99:103	arg1	healing					105:111	cutaneous wound healing	89:111	cutaneous wound healing	89:111	Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing.
33453408	1	69	theme	umbilical	163:171	arg1	cord					173:176	umbilical cord	163:176	umbilical cord	163:176	Perinatal-related tissues, such as the placenta, umbilical cord, and amniotic membrane, are generally discarded after delivery and are increasingly attracting attention as alternative sources for decellularized extracellular matrix (dECM) isolation.
33453408	0	70	from	glycosaminoglycans	9:26	arg1	matrix					55:60	decellularized placenta matrix	31:60	decellularized placenta matrix	31:60	Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing.
33453408	10	71	contain	has	1574:1576	arg2	effect					1599:1604	an anti-inflammatory effect	1578:1604	an anti-inflammatory effect	1578:1604	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	10	71	contain	has	1574:1576	arg1	CS					1542:1543	CS	1542:1543	CS with 6-O-sulfo group (CS-6S)	1542:1572	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	11	72	theme	tissue	1959:1964	arg1	engineering					1966:1976	tissue engineering	1959:1976	tissue engineering	1959:1976	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	4	73	from	membrane	751:758	arg1	glycosaminoglycanomics					672:693	the glycosaminoglycanomics	668:693	the glycosaminoglycanomics of dECMs from the placenta, umbilical cord and amniotic membrane	668:758	In this study, we explored the glycosaminoglycanomics of dECMs from the placenta, umbilical cord and amniotic membrane.
33453408	2	74	theme	tissue	453:458	arg1	regeneration					460:471	tissue regeneration	453:471	tissue regeneration	453:471	Recent studies indicate that glycosaminoglycans (GAGs) in the dECM play key roles during tissue regeneration.
33453408	10	75	theme	in	1506:1507	arg1	analyses					1515:1522	Further in vitro analyses	1498:1522	Further in vitro analyses	1498:1522	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
33453408	3	76	from	function	593:600	arg1	tissues					566:572	perinatal tissues	556:572	perinatal tissues	556:572	However, the dECM is organ specific, and the glycosaminoglycanomics of dECMs from perinatal tissues and the regulatory function of GAGs have been poorly investigated.
33453408	0	77	theme	decellularized	31:44	arg1	matrix					55:60	decellularized placenta matrix	31:60	decellularized placenta matrix	31:60	Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing.
33453408	1	78	theme	Perinatal-related	114:130	arg1	cord					173:176	umbilical cord	163:176	umbilical cord	163:176	Perinatal-related tissues, such as the placenta, umbilical cord, and amniotic membrane, are generally discarded after delivery and are increasingly attracting attention as alternative sources for decellularized extracellular matrix (dECM) isolation.
33453408	1	78	theme	Perinatal-related	114:130	arg1	membrane					192:199	amniotic membrane	183:199	amniotic membrane	183:199	Perinatal-related tissues, such as the placenta, umbilical cord, and amniotic membrane, are generally discarded after delivery and are increasingly attracting attention as alternative sources for decellularized extracellular matrix (dECM) isolation.
33453408	1	78	theme	Perinatal-related	114:130	arg1	placenta					153:160	the placenta	149:160	the placenta	149:160	Perinatal-related tissues, such as the placenta, umbilical cord, and amniotic membrane, are generally discarded after delivery and are increasingly attracting attention as alternative sources for decellularized extracellular matrix (dECM) isolation.
33453408	1	78	theme	Perinatal-related	114:130	arg1	tissues					132:138	Perinatal-related tissues	114:138	Perinatal-related tissues	114:138	Perinatal-related tissues, such as the placenta, umbilical cord, and amniotic membrane, are generally discarded after delivery and are increasingly attracting attention as alternative sources for decellularized extracellular matrix (dECM) isolation.
33453408	5	79	theme	therapeutic	786:796	arg1	related					819:825	related	819:825	related	819:825	We hypothesized that the therapeutic effects of dECMs are related to the detailed composition of GAGs.
33453408	5	79	theme	therapeutic	786:796	arg1	effects					798:804	the therapeutic effects	782:804	the therapeutic effects of dECMs	782:813	We hypothesized that the therapeutic effects of dECMs are related to the detailed composition of GAGs.
33453408	1	80	theme	decellularized	310:323	arg1	isolation					353:361	decellularized extracellular matrix (dECM) isolation	310:361	decellularized extracellular matrix (dECM) isolation	310:361	Perinatal-related tissues, such as the placenta, umbilical cord, and amniotic membrane, are generally discarded after delivery and are increasingly attracting attention as alternative sources for decellularized extracellular matrix (dECM) isolation.
33453408	6	81	theme	cutaneous	1055:1063	arg1	model					1079:1083	a murine cutaneous wound-healing model	1046:1083	a murine cutaneous wound-healing model	1046:1083	Hydrogels of dECM derived from perinatal tissues were generated, and glycosaminoglycanomics analysis was employed to identify the cues that promote tissue repair and regeneration in a murine cutaneous wound-healing model.
33453408	0	82	theme	critical	65:72	arg1	regulators					74:83	critical regulators	65:83	critical regulators for cutaneous wound healing	65:111	Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing.
33453408	1	83	theme	matrix	339:344	arg1	isolation					353:361	decellularized extracellular matrix (dECM) isolation	310:361	decellularized extracellular matrix (dECM) isolation	310:361	Perinatal-related tissues, such as the placenta, umbilical cord, and amniotic membrane, are generally discarded after delivery and are increasingly attracting attention as alternative sources for decellularized extracellular matrix (dECM) isolation.
33453408	11	84	theme	GAGs	1742:1745	arg1	roles					1733:1737	the critical roles	1720:1737	the critical roles of GAGs in perinatal tissue-derived dECMs	1720:1779	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	11	85	theme	placental	1904:1912	arg1	hydrogel					1919:1926	6-sulfated GAG-enriched placental dECM hydrogel	1880:1926	6-sulfated GAG-enriched placental dECM hydrogel	1880:1926	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	11	85	theme	placental	1904:1912	arg1	candidate					1945:1953	an attractive candidate	1931:1953	an attractive candidate for tissue engineering and drug delivery	1931:1994	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	4	86	from	cord	733:736	arg1	glycosaminoglycanomics					672:693	the glycosaminoglycanomics	668:693	the glycosaminoglycanomics of dECMs from the placenta, umbilical cord and amniotic membrane	668:758	In this study, we explored the glycosaminoglycanomics of dECMs from the placenta, umbilical cord and amniotic membrane.
33453408	11	87	theme	6-sulfated	1880:1889	arg1	hydrogel					1919:1926	6-sulfated GAG-enriched placental dECM hydrogel	1880:1926	6-sulfated GAG-enriched placental dECM hydrogel	1880:1926	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	11	87	theme	6-sulfated	1880:1889	arg1	candidate					1945:1953	an attractive candidate	1931:1953	an attractive candidate for tissue engineering and drug delivery	1931:1994	In conclusion, this study highlights the critical roles of GAGs in perinatal tissue-derived dECMs by promoting angiogenesis and inhibiting inflammation and indicates that it is feasible to utilize 6-sulfated GAG-enriched placental dECM hydrogel as an attractive candidate for tissue engineering and drug delivery.
33453408	10	88	theme	anti-inflammatory	1581:1597	arg1	effect					1599:1604	an anti-inflammatory effect	1578:1604	an anti-inflammatory effect	1578:1604	Further in vitro analyses demonstrated that CS with 6-O-sulfo group (CS-6S) has an anti-inflammatory effect, while HS with 6-O-sulfo group (HS-6S) plays a crucial role in angiogenesis.
34143163	9	0	from	perspective	1520:1530	arg1	media					1556:1560	porous media	1549:1560	porous media combined with the adsorption factor	1549:1596	In all, the proposed simulation method enabled the coagulation mechanism of PVA-CS to be revealed from the perspective of blood flow in porous media combined with the adsorption factor.
34143163	3	1	theme	porous	532:537	arg1	medium					539:544	a porous medium	530:544	a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	530:676	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	9	2	theme	simulation	1434:1443	arg1	method					1445:1450	the proposed simulation method	1421:1450	the proposed simulation method	1421:1450	In all, the proposed simulation method enabled the coagulation mechanism of PVA-CS to be revealed from the perspective of blood flow in porous media combined with the adsorption factor.
34143163	7	3	dep	pressure	1231:1238	arg1	distribution					1253:1264	distribution	1253:1264	distribution	1253:1264	Besides, simulation can provide the pressure and velocity distribution varying in the coagulation process of hemostatic materials.
34143163	7	3	dep	pressure	1231:1238	arg1	the					1227:1229	the	1227:1229	the	1227:1229	Besides, simulation can provide the pressure and velocity distribution varying in the coagulation process of hemostatic materials.
34143163	2	4	theme	porosity	384:391	arg1	generation					393:402	porosity generation	384:402	porosity generation	384:402	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	3	5	theme	PVA-CS	640:645	arg1	material					669:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	4	6	from	material	788:795	arg1	simulated					692:700	simulated	692:700	simulated	692:700	Moreover, we simulated the dynamic blood flow process and blood coagulation process in the PVA-CS hemostatic material by introducing the physical model.
34143163	3	7	theme	fluid	576:580	arg1	model					582:586	the power-law fluid model	562:586	the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	562:676	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	4	8	from	simulated	692:700	arg1	material					788:795	the PVA-CS hemostatic material	766:795	the PVA-CS hemostatic material	766:795	Moreover, we simulated the dynamic blood flow process and blood coagulation process in the PVA-CS hemostatic material by introducing the physical model.
34143163	5	9	theme	blood-containing	947:962	arg1	area					964:967	the blood-containing area	943:967	the blood-containing area	943:967	The simulation results show that the blood begins to coagulate, which affects the porosity and permeability of the blood-containing area, resulting in changing the porosity after blood flowed into the hemostatic material.
34143163	9	10	theme	blood	1535:1539	arg1	flow					1541:1544	blood flow	1535:1544	blood flow	1535:1544	In all, the proposed simulation method enabled the coagulation mechanism of PVA-CS to be revealed from the perspective of blood flow in porous media combined with the adsorption factor.
34143163	4	11	theme	PVA-CS	770:775	arg1	material					788:795	the PVA-CS hemostatic material	766:795	the PVA-CS hemostatic material	766:795	Moreover, we simulated the dynamic blood flow process and blood coagulation process in the PVA-CS hemostatic material by introducing the physical model.
34143163	4	12	theme	blood	714:718	arg1	process					725:731	the dynamic blood flow process	702:731	the dynamic blood flow process	702:731	Moreover, we simulated the dynamic blood flow process and blood coagulation process in the PVA-CS hemostatic material by introducing the physical model.
34143163	3	13	theme	coagulation	515:525	arg1	model					500:504	a physical model	489:504	a physical model of blood coagulation	489:525	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	2	14	theme	fluid	316:320	arg1	characteristics					281:295	characteristics	281:295	characteristics of a non-Newtonian fluid	281:320	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	2	14	theme	fluid	316:320	arg1	theory					254:259	the theory	250:259	the theory of porous media	250:275	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	2	15	theme	hemostatic	437:446	arg1	materials					448:456	hemostatic materials	437:456	hemostatic materials	437:456	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	9	16	theme	flow	1541:1544	arg1	perspective					1520:1530	the perspective	1516:1530	the perspective of blood flow in porous media combined with the adsorption factor	1516:1596	In all, the proposed simulation method enabled the coagulation mechanism of PVA-CS to be revealed from the perspective of blood flow in porous media combined with the adsorption factor.
34143163	2	17	theme	non-Newtonian	302:314	arg1	fluid					316:320	a non-Newtonian fluid	300:320	a non-Newtonian fluid	300:320	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	6	18	theme	blood	1086:1090	arg1	rate					1097:1100	The porosity, permeability, and blood flow rate	1054:1100	The porosity, permeability, and blood flow rate	1054:1100	The porosity, permeability, and blood flow rate will approach zero until the generated blood coagulation entirely blocked the porous medium.
34143163	5	19	theme	hemostatic	1033:1042	arg1	material					1044:1051	the hemostatic material	1029:1051	the hemostatic material	1029:1051	The simulation results show that the blood begins to coagulate, which affects the porosity and permeability of the blood-containing area, resulting in changing the porosity after blood flowed into the hemostatic material.
34143163	9	20	theme	porous	1549:1554	arg1	media					1556:1560	porous media	1549:1560	porous media combined with the adsorption factor	1549:1596	In all, the proposed simulation method enabled the coagulation mechanism of PVA-CS to be revealed from the perspective of blood flow in porous media combined with the adsorption factor.
34143163	9	21	theme	adsorption	1580:1589	arg1	factor					1591:1596	the adsorption factor	1576:1596	the adsorption factor	1576:1596	In all, the proposed simulation method enabled the coagulation mechanism of PVA-CS to be revealed from the perspective of blood flow in porous media combined with the adsorption factor.
34143163	2	22	theme	adsorption	346:355	arg1	factor					357:362	an adsorption factor	343:362	an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials	343:456	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	1	23	theme	actual	221:226	arg1	application					228:238	actual application	221:238	actual application	221:238	The blood-clotting performance and characteristics of hemostatic materials are critical for their development and actual application.
34143163	0	24	theme	Blood-clotting	0:13	arg1	model					15:19	Blood-clotting model and simulation analysis	0:43	model	15:19	Blood-clotting model and simulation analysis of polyvinyl alcohol-chitosan composite hemostatic materials.
34143163	1	25	theme	blood-clotting	111:124	arg1	critical					186:193	critical	186:193	critical	186:193	The blood-clotting performance and characteristics of hemostatic materials are critical for their development and actual application.
34143163	1	25	theme	blood-clotting	111:124	arg1	performance					126:136	The blood-clotting performance and characteristics	107:156	performance	126:136	The blood-clotting performance and characteristics of hemostatic materials are critical for their development and actual application.
34143163	4	26	theme	hemostatic	777:786	arg1	material					788:795	the PVA-CS hemostatic material	766:795	the PVA-CS hemostatic material	766:795	Moreover, we simulated the dynamic blood flow process and blood coagulation process in the PVA-CS hemostatic material by introducing the physical model.
34143163	2	27	theme	coagulation	414:424	arg1	process					426:432	blood coagulation process	408:432	blood coagulation process	408:432	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	0	28	theme	simulation	25:34	arg1	analysis					36:43	Blood-clotting model and simulation analysis	0:43	analysis	36:43	Blood-clotting model and simulation analysis of polyvinyl alcohol-chitosan composite hemostatic materials.
34143163	4	29	theme	coagulation	743:753	arg1	process					755:761	blood coagulation process	737:761	blood coagulation process	737:761	Moreover, we simulated the dynamic blood flow process and blood coagulation process in the PVA-CS hemostatic material by introducing the physical model.
34143163	9	30	theme	coagulation	1464:1474	arg1	mechanism					1476:1484	the coagulation mechanism	1460:1484	the coagulation mechanism of PVA-CS	1460:1494	In all, the proposed simulation method enabled the coagulation mechanism of PVA-CS to be revealed from the perspective of blood flow in porous media combined with the adsorption factor.
34143163	3	31	theme	vinyl	615:619	arg1	material					669:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	6	32	theme	permeability	1068:1079	arg1	rate					1097:1100	The porosity, permeability, and blood flow rate	1054:1100	The porosity, permeability, and blood flow rate	1054:1100	The porosity, permeability, and blood flow rate will approach zero until the generated blood coagulation entirely blocked the porous medium.
34143163	3	33	theme	proposed	601:608	arg1	material					669:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	5	34	theme	area	964:967	arg1	permeability					927:938	permeability	927:938	permeability	927:938	The simulation results show that the blood begins to coagulate, which affects the porosity and permeability of the blood-containing area, resulting in changing the porosity after blood flowed into the hemostatic material.
34143163	5	34	theme	area	964:967	arg1	porosity					914:921	porosity	914:921	porosity	914:921	The simulation results show that the blood begins to coagulate, which affects the porosity and permeability of the blood-containing area, resulting in changing the porosity after blood flowed into the hemostatic material.
34143163	3	35	theme	hemostatic	658:667	arg1	material					669:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	4	36	theme	dynamic	706:712	arg1	process					725:731	the dynamic blood flow process	702:731	the dynamic blood flow process	702:731	Moreover, we simulated the dynamic blood flow process and blood coagulation process in the PVA-CS hemostatic material by introducing the physical model.
34143163	5	37	theme	simulation	836:845	arg1	results					847:853	The simulation results	832:853	The simulation results	832:853	The simulation results show that the blood begins to coagulate, which affects the porosity and permeability of the blood-containing area, resulting in changing the porosity after blood flowed into the hemostatic material.
34143163	6	38	theme	generated	1131:1139	arg1	coagulation					1147:1157	the generated blood coagulation	1127:1157	the generated blood coagulation	1127:1157	The porosity, permeability, and blood flow rate will approach zero until the generated blood coagulation entirely blocked the porous medium.
34143163	7	39	theme	materials	1315:1323	arg1	process					1293:1299	the coagulation process	1277:1299	the coagulation process of hemostatic materials	1277:1323	Besides, simulation can provide the pressure and velocity distribution varying in the coagulation process of hemostatic materials.
34143163	2	40	theme	media	271:275	arg1	characteristics					281:295	characteristics	281:295	characteristics of a non-Newtonian fluid	281:320	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	2	40	theme	media	271:275	arg1	theory					254:259	the theory	250:259	the theory of porous media	250:275	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	9	41	theme	PVA-CS	1489:1494	arg1	mechanism					1476:1484	the coagulation mechanism	1460:1484	the coagulation mechanism of PVA-CS	1460:1494	In all, the proposed simulation method enabled the coagulation mechanism of PVA-CS to be revealed from the perspective of blood flow in porous media combined with the adsorption factor.
34143163	6	42	theme	porosity	1058:1065	arg1	rate					1097:1100	The porosity, permeability, and blood flow rate	1054:1100	The porosity, permeability, and blood flow rate	1054:1100	The porosity, permeability, and blood flow rate will approach zero until the generated blood coagulation entirely blocked the porous medium.
34143163	6	43	theme	flow	1092:1095	arg1	rate					1097:1100	The porosity, permeability, and blood flow rate	1054:1100	The porosity, permeability, and blood flow rate	1054:1100	The porosity, permeability, and blood flow rate will approach zero until the generated blood coagulation entirely blocked the porous medium.
34143163	2	44	theme	porous	264:269	arg1	media					271:275	porous media	264:275	porous media	264:275	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	2	45	theme	materials	448:456	arg1	generation					393:402	porosity generation	384:402	porosity generation	384:402	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	2	45	theme	materials	448:456	arg1	process					426:432	blood coagulation process	408:432	blood coagulation process	408:432	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	8	46	theme	material	1403:1410	arg1	performance					1377:1387	the hemostatic performance	1362:1387	the hemostatic performance of the PVA-CS material	1362:1410	The temperature will also influence the hemostatic performance of the PVA-CS material.
34143163	3	47	theme	composite	648:656	arg1	material					669:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	3	48	theme	poly	610:613	arg1	material					669:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	5	49	dep	porosity	914:921	arg1	the					910:912	the	910:912	the	910:912	The simulation results show that the blood begins to coagulate, which affects the porosity and permeability of the blood-containing area, resulting in changing the porosity after blood flowed into the hemostatic material.
34143163	6	50	theme	blood	1141:1145	arg1	coagulation					1147:1157	the generated blood coagulation	1127:1157	the generated blood coagulation	1127:1157	The porosity, permeability, and blood flow rate will approach zero until the generated blood coagulation entirely blocked the porous medium.
34143163	0	51	theme	polyvinyl	48:56	arg1	model					15:19	Blood-clotting model and simulation analysis	0:43	model	15:19	Blood-clotting model and simulation analysis of polyvinyl alcohol-chitosan composite hemostatic materials.
34143163	0	51	theme	polyvinyl	48:56	arg1	analysis					36:43	Blood-clotting model and simulation analysis	0:43	analysis	36:43	Blood-clotting model and simulation analysis of polyvinyl alcohol-chitosan composite hemostatic materials.
34143163	4	52	theme	flow	720:723	arg1	process					725:731	the dynamic blood flow process	702:731	the dynamic blood flow process	702:731	Moreover, we simulated the dynamic blood flow process and blood coagulation process in the PVA-CS hemostatic material by introducing the physical model.
34143163	4	53	theme	blood	737:741	arg1	process					755:761	blood coagulation process	737:761	blood coagulation process	737:761	Moreover, we simulated the dynamic blood flow process and blood coagulation process in the PVA-CS hemostatic material by introducing the physical model.
34143163	4	54	theme	physical	816:823	arg1	model					825:829	the physical model	812:829	the physical model	812:829	Moreover, we simulated the dynamic blood flow process and blood coagulation process in the PVA-CS hemostatic material by introducing the physical model.
34143163	8	55	theme	PVA-CS	1396:1401	arg1	material					1403:1410	the PVA-CS material	1392:1410	the PVA-CS material	1392:1410	The temperature will also influence the hemostatic performance of the PVA-CS material.
34143163	3	56	theme	alcohol	621:627	arg1	material					669:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	1	57	theme	hemostatic	161:170	arg1	materials					172:180	hemostatic materials	161:180	hemostatic materials	161:180	The blood-clotting performance and characteristics of hemostatic materials are critical for their development and actual application.
34143163	3	58	theme	power-law	566:574	arg1	model					582:586	the power-law fluid model	562:586	the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	562:676	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	7	59	theme	hemostatic	1304:1313	arg1	materials					1315:1323	hemostatic materials	1304:1323	hemostatic materials	1304:1323	Besides, simulation can provide the pressure and velocity distribution varying in the coagulation process of hemostatic materials.
34143163	2	60	dep	generation	393:402	arg1	the					380:382	the	380:382	the	380:382	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	1	61	theme	materials	172:180	arg1	critical					186:193	critical	186:193	critical	186:193	The blood-clotting performance and characteristics of hemostatic materials are critical for their development and actual application.
34143163	1	61	theme	materials	172:180	arg1	characteristics					142:156	The blood-clotting performance and characteristics	107:156	characteristics	142:156	The blood-clotting performance and characteristics of hemostatic materials are critical for their development and actual application.
34143163	1	61	theme	materials	172:180	arg1	performance					126:136	The blood-clotting performance and characteristics	107:156	performance	126:136	The blood-clotting performance and characteristics of hemostatic materials are critical for their development and actual application.
34143163	8	62	theme	hemostatic	1366:1375	arg1	performance					1377:1387	the hemostatic performance	1362:1387	the hemostatic performance of the PVA-CS material	1362:1410	The temperature will also influence the hemostatic performance of the PVA-CS material.
34143163	3	63	theme	blood	509:513	arg1	coagulation					515:525	blood coagulation	509:525	blood coagulation	509:525	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	0	64	theme	hemostatic	85:94	arg1	materials					96:104	composite hemostatic materials	75:104	composite hemostatic materials	75:104	Blood-clotting model and simulation analysis of polyvinyl alcohol-chitosan composite hemostatic materials.
34143163	3	65	theme	physical	491:498	arg1	model					500:504	a physical model	489:504	a physical model of blood coagulation	489:525	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	6	66	theme	porous	1180:1185	arg1	medium					1187:1192	the porous medium	1176:1192	the porous medium	1176:1192	The porosity, permeability, and blood flow rate will approach zero until the generated blood coagulation entirely blocked the porous medium.
34143163	2	67	theme	blood	408:412	arg1	process					426:432	blood coagulation process	408:432	blood coagulation process	408:432	Based on the theory of porous media and characteristics of a non-Newtonian fluid, this study proposed an adsorption factor to characterize the porosity generation and blood coagulation process of hemostatic materials.
34143163	0	68	theme	composite	75:83	arg1	materials					96:104	composite hemostatic materials	75:104	composite hemostatic materials	75:104	Blood-clotting model and simulation analysis of polyvinyl alcohol-chitosan composite hemostatic materials.
34143163	3	69	theme	-chitosan	629:637	arg1	material					669:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material	597:676	On this basis, we constructed a physical model of blood coagulation in a porous medium integrated with the power-law fluid model to study the proposed poly(vinyl alcohol)-chitosan (PVA-CS) composite hemostatic material.
34143163	7	70	theme	coagulation	1281:1291	arg1	process					1293:1299	the coagulation process	1277:1299	the coagulation process of hemostatic materials	1277:1323	Besides, simulation can provide the pressure and velocity distribution varying in the coagulation process of hemostatic materials.
34143163	9	71	theme	proposed	1425:1432	arg1	method					1445:1450	the proposed simulation method	1421:1450	the proposed simulation method	1421:1450	In all, the proposed simulation method enabled the coagulation mechanism of PVA-CS to be revealed from the perspective of blood flow in porous media combined with the adsorption factor.
34942326	8	0	theme	low	1101:1103	arg1	device					1185:1190	a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device	1099:1190	a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device	1099:1190	The formulations were evaluated in vitro using a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device, the Handihaler®.
34942326	8	0	theme	low	1101:1103	arg1	Handihaler®					1197:1207	the Handihaler®	1193:1207	the Handihaler®	1193:1207	The formulations were evaluated in vitro using a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device, the Handihaler®.
34942326	4	1	theme	applications	546:557	arg1	robustness					518:527	robustness	518:527	robustness	518:527	The aim of the current study was to test the robustness and the range of applications of the two measurements, among other rheological measurements.
34942326	4	1	theme	applications	546:557	arg1	range					537:541	the range	533:541	the range of applications	533:557	The aim of the current study was to test the robustness and the range of applications of the two measurements, among other rheological measurements.
34942326	6	2	theme	α-lactose	787:795	arg1	blends					810:815	coarse-fine excipient (α-lactose monohydrate) blends	764:815	coarse-fine excipient (α-lactose monohydrate) blends	764:815	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	8	3	theme	inhalation	1116:1125	arg1	device					1127:1132	resistance inhalation device	1105:1132	resistance inhalation device	1105:1132	The formulations were evaluated in vitro using a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device, the Handihaler®.
34942326	6	4	theme	w/w	875:877	arg1	concentrations					848:861	different fine excipient concentrations	823:861	different fine excipient concentrations (0.0-15.0 % w/w)	823:878	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	6	4	theme	w/w	875:877	arg1	%					873:873	0.0-15.0 % w/w	864:877	0.0-15.0 % w/w	864:877	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	12	5	theme	specific	1748:1755	arg1	energy					1757:1762	the specific energy	1744:1762	the specific energy	1744:1762	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	12	5	theme	specific	1748:1755	arg1	measurements					1687:1698	dynamic rheological measurements	1667:1698	dynamic rheological measurements	1667:1698	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	11	6	theme	powder	1587:1592	arg1	formulations					1605:1616	carrier-based dry powder inhalation formulations	1569:1616	carrier-based dry powder inhalation formulations	1569:1616	They hold a potential for use as critical material attributes to aid monitoring and optimization of carrier-based dry powder inhalation formulations in quality-by-design systems.
34942326	6	7	theme	excipient	776:784	arg1	blends					810:815	coarse-fine excipient (α-lactose monohydrate) blends	764:815	coarse-fine excipient (α-lactose monohydrate) blends	764:815	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	2	8	theme	different	264:272	arg1	aspects					274:280	different aspects	264:280	different aspects of powder flow and packing	264:307	Various static (bulk) and dynamic rheological measurements are used to study different aspects of powder flow and packing.
34942326	6	9	with	material	929:936	arg1	concentrations					848:861	different fine excipient concentrations	823:861	different fine excipient concentrations (0.0-15.0 % w/w)	823:878	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	6	9	with	material	929:936	arg1	%					873:873	0.0-15.0 % w/w	864:877	0.0-15.0 % w/w	864:877	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	10	10	theme	satisfactory	1379:1390	arg1	precision					1392:1400	satisfactory precision	1379:1400	satisfactory precision	1379:1400	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	1	11	theme	powder	155:160	arg1	formulations					173:184	dry powder inhalation formulations	151:184	dry powder inhalation formulations	151:184	Study of flow is a key to development of dry powder inhalation formulations.
34942326	8	12	theme	Cyclohaler®	1139:1149	arg1	device					1185:1190	a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device	1099:1190	a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device	1099:1190	The formulations were evaluated in vitro using a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device, the Handihaler®.
34942326	8	12	theme	Cyclohaler®	1139:1149	arg1	Handihaler®					1197:1207	the Handihaler®	1193:1207	the Handihaler®	1193:1207	The formulations were evaluated in vitro using a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device, the Handihaler®.
34942326	12	13	theme	flowability	1724:1734	arg1	measurements					1687:1698	dynamic rheological measurements	1667:1698	dynamic rheological measurements	1667:1698	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	12	13	theme	flowability	1724:1734	arg1	energy					1736:1741	the basic flowability energy	1714:1741	the basic flowability energy	1714:1741	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	2	14	used	used	250:253	arg2	measurements					233:244	Various static (bulk) and dynamic rheological measurements	187:244	Various static (bulk) and dynamic rheological measurements	187:244	Various static (bulk) and dynamic rheological measurements are used to study different aspects of powder flow and packing.
34942326	7	15	theme	properties	1040:1049	arg1	terms					982:986	terms	982:986	terms of morphology, size, crystallinity, and rheological properties	982:1049	The excipient blends were characterized in terms of morphology, size, crystallinity, and rheological properties.
34942326	2	16	theme	flow	292:295	arg1	aspects					274:280	different aspects	264:280	different aspects of powder flow and packing	264:307	Various static (bulk) and dynamic rheological measurements are used to study different aspects of powder flow and packing.
34942326	1	17	theme	formulations	173:184	arg1	development					136:146	development	136:146	development of dry powder inhalation formulations	136:184	Study of flow is a key to development of dry powder inhalation formulations.
34942326	11	18	theme	critical	1502:1509	arg1	attributes					1520:1529	critical material attributes	1502:1529	critical material attributes	1502:1529	They hold a potential for use as critical material attributes to aid monitoring and optimization of carrier-based dry powder inhalation formulations in quality-by-design systems.
34942326	4	19	theme	rheological	596:606	arg1	measurements					608:619	other rheological measurements	590:619	other rheological measurements	590:619	The aim of the current study was to test the robustness and the range of applications of the two measurements, among other rheological measurements.
34942326	11	20	from	optimization	1553:1564	arg1	systems					1639:1645	quality-by-design systems	1621:1645	quality-by-design systems	1621:1645	They hold a potential for use as critical material attributes to aid monitoring and optimization of carrier-based dry powder inhalation formulations in quality-by-design systems.
34942326	8	21	theme	high	1158:1161	arg1	inhalation					1174:1183	a high resistance inhalation	1156:1183	a high resistance inhalation	1156:1183	The formulations were evaluated in vitro using a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device, the Handihaler®.
34942326	6	22	theme	fluticasone	905:915	arg1	drug					899:902	a spray-dried drug	885:902	a spray-dried drug (fluticasone propionate) material	885:936	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	6	22	theme	fluticasone	905:915	arg1	propionate					917:926	fluticasone propionate	905:926	fluticasone propionate	905:926	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	5	23	theme	ternary	671:677	arg1	formulations					716:727	ternary, carrier-based dry powder inhalation formulations	671:727	ternary, carrier-based dry powder inhalation formulations	671:727	To this end, we prepared and studied a series of ternary, carrier-based dry powder inhalation formulations.
34942326	8	24	theme	inhalation	1174:1183	arg1	device					1185:1190	a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device	1099:1190	a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device	1099:1190	The formulations were evaluated in vitro using a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device, the Handihaler®.
34942326	8	24	theme	inhalation	1174:1183	arg1	Handihaler®					1197:1207	the Handihaler®	1193:1207	the Handihaler®	1193:1207	The formulations were evaluated in vitro using a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device, the Handihaler®.
34942326	10	25	from	changes	1424:1430	arg1	structure					1458:1466	structure	1458:1466	structure	1458:1466	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	10	25	from	changes	1424:1430	arg1	composition					1442:1452	powder composition	1435:1452	powder composition	1435:1452	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	0	26	from	development	59:69	arg1	potential					18:26	the potential	14:26	the potential of rheological measurements in development of dry powder inhalation formulations	14:107	Insights into the potential of rheological measurements in development of dry powder inhalation formulations.
34942326	7	27	theme	size	1003:1006	arg1	terms					982:986	terms	982:986	terms of morphology, size, crystallinity, and rheological properties	982:1049	The excipient blends were characterized in terms of morphology, size, crystallinity, and rheological properties.
34942326	1	28	theme	flow	119:122	arg1	key					129:131	key	129:131	key	129:131	Study of flow is a key to development of dry powder inhalation formulations.
34942326	1	28	theme	flow	119:122	arg1	Study					110:114	Study	110:114	Study of flow	110:122	Study of flow is a key to development of dry powder inhalation formulations.
34942326	13	29	theme	structural	1979:1988	arg1	changes					1990:1996	structural changes	1979:1996	structural changes taking place during powder fluidization	1979:2036	The fluidization energy could, nevertheless, convey structural changes taking place during powder fluidization.
34942326	7	30	theme	morphology	991:1000	arg1	terms					982:986	terms	982:986	terms of morphology, size, crystallinity, and rheological properties	982:1049	The excipient blends were characterized in terms of morphology, size, crystallinity, and rheological properties.
34942326	9	31	theme	study	1214:1218	arg1	design					1220:1225	The study design	1210:1225	The study design	1210:1225	The study design aimed to complement literature data.
34942326	7	32	theme	excipient	943:951	arg1	blends					953:958	The excipient blends	939:958	The excipient blends	939:958	The excipient blends were characterized in terms of morphology, size, crystallinity, and rheological properties.
34942326	11	33	from	monitoring	1538:1547	arg1	systems					1639:1645	quality-by-design systems	1621:1645	quality-by-design systems	1621:1645	They hold a potential for use as critical material attributes to aid monitoring and optimization of carrier-based dry powder inhalation formulations in quality-by-design systems.
34942326	12	34	theme	basic	1718:1722	arg1	measurements					1687:1698	dynamic rheological measurements	1667:1698	dynamic rheological measurements	1667:1698	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	12	34	theme	basic	1718:1722	arg1	energy					1736:1741	the basic flowability energy	1714:1741	the basic flowability energy	1714:1741	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	5	35	theme	formulations	716:727	arg1	series					661:666	a series	659:666	a series of ternary, carrier-based dry powder inhalation formulations	659:727	To this end, we prepared and studied a series of ternary, carrier-based dry powder inhalation formulations.
34942326	2	36	theme	rheological	221:231	arg1	measurements					233:244	Various static (bulk) and dynamic rheological measurements	187:244	Various static (bulk) and dynamic rheological measurements	187:244	Various static (bulk) and dynamic rheological measurements are used to study different aspects of powder flow and packing.
34942326	12	37	theme	dynamic	1667:1673	arg1	energy					1786:1791	the fluidization energy	1769:1791	the fluidization energy	1769:1791	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	12	37	theme	dynamic	1667:1673	arg1	energy					1757:1762	the specific energy	1744:1762	the specific energy	1744:1762	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	12	37	theme	dynamic	1667:1673	arg1	measurements					1687:1698	dynamic rheological measurements	1667:1698	dynamic rheological measurements	1667:1698	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	12	37	theme	dynamic	1667:1673	arg1	energy					1736:1741	the basic flowability energy	1714:1741	the basic flowability energy	1714:1741	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	0	38	theme	dry	74:76	arg1	formulations					96:107	dry powder inhalation formulations	74:107	dry powder inhalation formulations	74:107	Insights into the potential of rheological measurements in development of dry powder inhalation formulations.
34942326	4	39	theme	current	488:494	arg1	study					496:500	the current study	484:500	the current study	484:500	The aim of the current study was to test the robustness and the range of applications of the two measurements, among other rheological measurements.
34942326	0	40	theme	inhalation	85:94	arg1	formulations					96:107	dry powder inhalation formulations	74:107	dry powder inhalation formulations	74:107	Insights into the potential of rheological measurements in development of dry powder inhalation formulations.
34942326	0	41	from	measurements	43:54	arg1	development					59:69	development	59:69	development of dry powder inhalation formulations	59:107	Insights into the potential of rheological measurements in development of dry powder inhalation formulations.
34942326	5	42	theme	powder	698:703	arg1	formulations					716:727	ternary, carrier-based dry powder inhalation formulations	671:727	ternary, carrier-based dry powder inhalation formulations	671:727	To this end, we prepared and studied a series of ternary, carrier-based dry powder inhalation formulations.
34942326	3	43	theme	fluidization	367:378	arg1	energy					380:385	the fluidization energy	363:385	the fluidization energy	363:385	Among rheological measurements, the permeability and the fluidization energy are, conceptually, most relevant to dispersion of dry powder inhalation formulations.
34942326	3	43	theme	fluidization	367:378	arg1	relevant					411:418	relevant	411:418	relevant	411:418	Among rheological measurements, the permeability and the fluidization energy are, conceptually, most relevant to dispersion of dry powder inhalation formulations.
34942326	12	44	theme	powder	1908:1913	arg1	structures					1915:1924	heterogeneous powder structures	1894:1924	heterogeneous powder structures	1894:1924	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	10	45	theme	Bulk	1264:1267	arg1	density					1317:1323	the bulk density	1308:1323	the bulk density	1308:1323	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	10	45	theme	Bulk	1264:1267	arg1	measurements					1281:1292	Bulk rheological measurements	1264:1292	Bulk rheological measurements	1264:1292	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	10	45	theme	Bulk	1264:1267	arg1	compressibility					1330:1344	the compressibility	1326:1344	the compressibility	1326:1344	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	10	45	theme	Bulk	1264:1267	arg1	permeability					1355:1366	the permeability	1351:1366	the permeability	1351:1366	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	3	46	theme	powder	441:446	arg1	formulations					459:470	dry powder inhalation formulations	437:470	dry powder inhalation formulations	437:470	Among rheological measurements, the permeability and the fluidization energy are, conceptually, most relevant to dispersion of dry powder inhalation formulations.
34942326	6	47	theme	excipient	838:846	arg1	concentrations					848:861	different fine excipient concentrations	823:861	different fine excipient concentrations (0.0-15.0 % w/w)	823:878	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	6	47	theme	excipient	838:846	arg1	%					873:873	0.0-15.0 % w/w	864:877	0.0-15.0 % w/w	864:877	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	12	48	theme	measurements	1869:1880	arg1	interpretation					1847:1860	interpretation	1847:1860	interpretation of the measurements	1847:1880	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	6	49	theme	different	823:831	arg1	concentrations					848:861	different fine excipient concentrations	823:861	different fine excipient concentrations (0.0-15.0 % w/w)	823:878	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	6	49	theme	different	823:831	arg1	%					873:873	0.0-15.0 % w/w	864:877	0.0-15.0 % w/w	864:877	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	6	50	with	blends	810:815	arg1	concentrations					848:861	different fine excipient concentrations	823:861	different fine excipient concentrations (0.0-15.0 % w/w)	823:878	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	6	50	with	blends	810:815	arg1	%					873:873	0.0-15.0 % w/w	864:877	0.0-15.0 % w/w	864:877	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	3	51	theme	rheological	316:326	arg1	measurements					328:339	rheological measurements	316:339	rheological measurements	316:339	Among rheological measurements, the permeability and the fluidization energy are, conceptually, most relevant to dispersion of dry powder inhalation formulations.
34942326	11	52	theme	carrier-based	1569:1581	arg1	formulations					1605:1616	carrier-based dry powder inhalation formulations	1569:1616	carrier-based dry powder inhalation formulations	1569:1616	They hold a potential for use as critical material attributes to aid monitoring and optimization of carrier-based dry powder inhalation formulations in quality-by-design systems.
34942326	0	53	theme	measurements	43:54	arg1	potential					18:26	the potential	14:26	the potential of rheological measurements in development of dry powder inhalation formulations	14:107	Insights into the potential of rheological measurements in development of dry powder inhalation formulations.
34942326	2	54	theme	static	195:200	arg1	measurements					233:244	Various static (bulk) and dynamic rheological measurements	187:244	Various static (bulk) and dynamic rheological measurements	187:244	Various static (bulk) and dynamic rheological measurements are used to study different aspects of powder flow and packing.
34942326	3	55	theme	formulations	459:470	arg1	dispersion					423:432	dispersion	423:432	dispersion of dry powder inhalation formulations	423:470	Among rheological measurements, the permeability and the fluidization energy are, conceptually, most relevant to dispersion of dry powder inhalation formulations.
34942326	12	56	theme	fluidization	1773:1784	arg1	energy					1786:1791	the fluidization energy	1769:1791	the fluidization energy	1769:1791	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	12	56	theme	fluidization	1773:1784	arg1	measurements					1687:1698	dynamic rheological measurements	1667:1698	dynamic rheological measurements	1667:1698	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	11	57	theme	formulations	1605:1616	arg1	optimization					1553:1564	optimization	1553:1564	optimization	1553:1564	They hold a potential for use as critical material attributes to aid monitoring and optimization of carrier-based dry powder inhalation formulations in quality-by-design systems.
34942326	11	57	theme	formulations	1605:1616	arg1	monitoring					1538:1547	monitoring	1538:1547	monitoring	1538:1547	They hold a potential for use as critical material attributes to aid monitoring and optimization of carrier-based dry powder inhalation formulations in quality-by-design systems.
34942326	2	58	dep	static	195:200	arg1	bulk					203:206	bulk	203:206	bulk	203:206	Various static (bulk) and dynamic rheological measurements are used to study different aspects of powder flow and packing.
34942326	10	59	theme	bulk	1312:1315	arg1	density					1317:1323	the bulk density	1308:1323	the bulk density	1308:1323	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	10	59	theme	bulk	1312:1315	arg1	measurements					1281:1292	Bulk rheological measurements	1264:1292	Bulk rheological measurements	1264:1292	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	11	60	theme	quality-by-design	1621:1637	arg1	systems					1639:1645	quality-by-design systems	1621:1645	quality-by-design systems	1621:1645	They hold a potential for use as critical material attributes to aid monitoring and optimization of carrier-based dry powder inhalation formulations in quality-by-design systems.
34942326	11	61	theme	material	1511:1518	arg1	attributes					1520:1529	critical material attributes	1502:1529	critical material attributes	1502:1529	They hold a potential for use as critical material attributes to aid monitoring and optimization of carrier-based dry powder inhalation formulations in quality-by-design systems.
34942326	8	62	theme	resistance	1105:1114	arg1	device					1127:1132	resistance inhalation device	1105:1132	resistance inhalation device	1105:1132	The formulations were evaluated in vitro using a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device, the Handihaler®.
34942326	6	63	theme	coarse-fine	764:774	arg1	blends					810:815	coarse-fine excipient (α-lactose monohydrate) blends	764:815	coarse-fine excipient (α-lactose monohydrate) blends	764:815	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	1	64	theme	dry	151:153	arg1	formulations					173:184	dry powder inhalation formulations	151:184	dry powder inhalation formulations	151:184	Study of flow is a key to development of dry powder inhalation formulations.
34942326	8	65	theme	device	1127:1132	arg1	device					1185:1190	a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device	1099:1190	a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device	1099:1190	The formulations were evaluated in vitro using a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device, the Handihaler®.
34942326	8	65	theme	device	1127:1132	arg1	Handihaler®					1197:1207	the Handihaler®	1193:1207	the Handihaler®	1193:1207	The formulations were evaluated in vitro using a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device, the Handihaler®.
34942326	7	66	theme	rheological	1028:1038	arg1	properties					1040:1049	rheological properties	1028:1049	rheological properties	1028:1049	The excipient blends were characterized in terms of morphology, size, crystallinity, and rheological properties.
34942326	1	67	theme	inhalation	162:171	arg1	formulations					173:184	dry powder inhalation formulations	151:184	dry powder inhalation formulations	151:184	Study of flow is a key to development of dry powder inhalation formulations.
34942326	6	68	theme	material	929:936	arg1	mixtures					752:759	mixtures	752:759	mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material	752:936	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	6	68	theme	material	929:936	arg1	formulations					734:745	The formulations	730:745	The formulations	730:745	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	2	69	theme	powder	285:290	arg1	flow					292:295	powder flow	285:295	powder flow	285:295	Various static (bulk) and dynamic rheological measurements are used to study different aspects of powder flow and packing.
34942326	4	70	theme	other	590:594	arg1	measurements					608:619	other rheological measurements	590:619	other rheological measurements	590:619	The aim of the current study was to test the robustness and the range of applications of the two measurements, among other rheological measurements.
34942326	2	71	theme	dynamic	213:219	arg1	measurements					233:244	Various static (bulk) and dynamic rheological measurements	187:244	Various static (bulk) and dynamic rheological measurements	187:244	Various static (bulk) and dynamic rheological measurements are used to study different aspects of powder flow and packing.
34942326	8	72	theme	resistance	1163:1172	arg1	inhalation					1174:1183	a high resistance inhalation	1156:1183	a high resistance inhalation	1156:1183	The formulations were evaluated in vitro using a low resistance inhalation device, the Cyclohaler®, and a high resistance inhalation device, the Handihaler®.
34942326	6	73	theme	spray-dried	887:897	arg1	drug					899:902	a spray-dried drug	885:902	a spray-dried drug (fluticasone propionate) material	885:936	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	6	73	theme	spray-dried	887:897	arg1	propionate					917:926	fluticasone propionate	905:926	fluticasone propionate	905:926	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	13	74	theme	fluidization	1931:1942	arg1	energy					1944:1949	The fluidization energy	1927:1949	The fluidization energy	1927:1949	The fluidization energy could, nevertheless, convey structural changes taking place during powder fluidization.
34942326	5	75	theme	inhalation	705:714	arg1	formulations					716:727	ternary, carrier-based dry powder inhalation formulations	671:727	ternary, carrier-based dry powder inhalation formulations	671:727	To this end, we prepared and studied a series of ternary, carrier-based dry powder inhalation formulations.
34942326	5	76	dep	ternary	671:677	arg1	carrier-based					680:692	carrier-based	680:692	carrier-based	680:692	To this end, we prepared and studied a series of ternary, carrier-based dry powder inhalation formulations.
34942326	0	77	from	potential	18:26	arg1	development					59:69	development	59:69	development of dry powder inhalation formulations	59:107	Insights into the potential of rheological measurements in development of dry powder inhalation formulations.
34942326	0	78	theme	powder	78:83	arg1	formulations					96:107	dry powder inhalation formulations	74:107	dry powder inhalation formulations	74:107	Insights into the potential of rheological measurements in development of dry powder inhalation formulations.
34942326	4	79	theme	study	496:500	arg1	aim					477:479	The aim	473:479	The aim of the current study	473:500	The aim of the current study was to test the robustness and the range of applications of the two measurements, among other rheological measurements.
34942326	0	80	theme	formulations	96:107	arg1	development					59:69	development	59:69	development of dry powder inhalation formulations	59:107	Insights into the potential of rheological measurements in development of dry powder inhalation formulations.
34942326	9	81	theme	literature	1247:1256	arg1	data					1258:1261	literature data	1247:1261	literature data	1247:1261	The study design aimed to complement literature data.
34942326	12	82	theme	rheological	1675:1685	arg1	energy					1786:1791	the fluidization energy	1769:1791	the fluidization energy	1769:1791	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	12	82	theme	rheological	1675:1685	arg1	energy					1757:1762	the specific energy	1744:1762	the specific energy	1744:1762	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	12	82	theme	rheological	1675:1685	arg1	measurements					1687:1698	dynamic rheological measurements	1667:1698	dynamic rheological measurements	1667:1698	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	12	82	theme	rheological	1675:1685	arg1	energy					1736:1741	the basic flowability energy	1714:1741	the basic flowability energy	1714:1741	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	5	83	theme	dry	694:696	arg1	formulations					716:727	ternary, carrier-based dry powder inhalation formulations	671:727	ternary, carrier-based dry powder inhalation formulations	671:727	To this end, we prepared and studied a series of ternary, carrier-based dry powder inhalation formulations.
34942326	12	84	theme	heterogeneous	1894:1906	arg1	structures					1915:1924	heterogeneous powder structures	1894:1924	heterogeneous powder structures	1894:1924	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	10	85	theme	powder	1435:1440	arg1	composition					1442:1452	powder composition	1435:1452	powder composition	1435:1452	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	4	86	dep	robustness	518:527	arg1	the					514:516	the	514:516	the	514:516	The aim of the current study was to test the robustness and the range of applications of the two measurements, among other rheological measurements.
34942326	12	87	theme	other	1655:1659	arg1	hand					1661:1664	the other hand	1651:1664	the other hand	1651:1664	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	10	88	theme	rheological	1269:1279	arg1	density					1317:1323	the bulk density	1308:1323	the bulk density	1308:1323	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	10	88	theme	rheological	1269:1279	arg1	measurements					1281:1292	Bulk rheological measurements	1264:1292	Bulk rheological measurements	1264:1292	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	10	88	theme	rheological	1269:1279	arg1	compressibility					1330:1344	the compressibility	1326:1344	the compressibility	1326:1344	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	10	88	theme	rheological	1269:1279	arg1	permeability					1355:1366	the permeability	1351:1366	the permeability	1351:1366	Bulk rheological measurements, specifically the bulk density, the compressibility, and the permeability, exhibited satisfactory precision and could demonstrate changes in powder composition and structure.
34942326	3	89	theme	inhalation	448:457	arg1	formulations					459:470	dry powder inhalation formulations	437:470	dry powder inhalation formulations	437:470	Among rheological measurements, the permeability and the fluidization energy are, conceptually, most relevant to dispersion of dry powder inhalation formulations.
34942326	0	90	theme	rheological	31:41	arg1	measurements					43:54	rheological measurements	31:54	rheological measurements in development of dry powder inhalation formulations	31:107	Insights into the potential of rheological measurements in development of dry powder inhalation formulations.
34942326	6	91	theme	fine	833:836	arg1	concentrations					848:861	different fine excipient concentrations	823:861	different fine excipient concentrations (0.0-15.0 % w/w)	823:878	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	6	91	theme	fine	833:836	arg1	%					873:873	0.0-15.0 % w/w	864:877	0.0-15.0 % w/w	864:877	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	3	92	theme	dry	437:439	arg1	formulations					459:470	dry powder inhalation formulations	437:470	dry powder inhalation formulations	437:470	Among rheological measurements, the permeability and the fluidization energy are, conceptually, most relevant to dispersion of dry powder inhalation formulations.
34942326	7	93	theme	crystallinity	1009:1021	arg1	terms					982:986	terms	982:986	terms of morphology, size, crystallinity, and rheological properties	982:1049	The excipient blends were characterized in terms of morphology, size, crystallinity, and rheological properties.
34942326	6	94	theme	blends	810:815	arg1	mixtures					752:759	mixtures	752:759	mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material	752:936	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	6	94	theme	blends	810:815	arg1	formulations					734:745	The formulations	730:745	The formulations	730:745	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	12	95	theme	high	1814:1817	arg1	variability					1819:1829	high variability	1814:1829	high variability	1814:1829	On the other hand, dynamic rheological measurements, specifically the basic flowability energy, the specific energy, and the fluidization energy, generally exhibited high variability, which obscured interpretation of the measurements and implied heterogeneous powder structures.
34942326	13	96	theme	powder	2018:2023	arg1	fluidization					2025:2036	powder fluidization	2018:2036	powder fluidization	2018:2036	The fluidization energy could, nevertheless, convey structural changes taking place during powder fluidization.
34942326	4	97	theme	measurements	570:581	arg1	robustness					518:527	robustness	518:527	robustness	518:527	The aim of the current study was to test the robustness and the range of applications of the two measurements, among other rheological measurements.
34942326	4	97	theme	measurements	570:581	arg1	range					537:541	the range	533:541	the range of applications	533:557	The aim of the current study was to test the robustness and the range of applications of the two measurements, among other rheological measurements.
34942326	2	98	theme	Various	187:193	arg1	measurements					233:244	Various static (bulk) and dynamic rheological measurements	187:244	Various static (bulk) and dynamic rheological measurements	187:244	Various static (bulk) and dynamic rheological measurements are used to study different aspects of powder flow and packing.
34942326	11	99	theme	inhalation	1594:1603	arg1	formulations					1605:1616	carrier-based dry powder inhalation formulations	1569:1616	carrier-based dry powder inhalation formulations	1569:1616	They hold a potential for use as critical material attributes to aid monitoring and optimization of carrier-based dry powder inhalation formulations in quality-by-design systems.
34942326	2	100	theme	packing	301:307	arg1	aspects					274:280	different aspects	264:280	different aspects of powder flow and packing	264:307	Various static (bulk) and dynamic rheological measurements are used to study different aspects of powder flow and packing.
34942326	6	101	theme	monohydrate	797:807	arg1	blends					810:815	coarse-fine excipient (α-lactose monohydrate) blends	764:815	coarse-fine excipient (α-lactose monohydrate) blends	764:815	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34942326	11	102	theme	dry	1583:1585	arg1	formulations					1605:1616	carrier-based dry powder inhalation formulations	1569:1616	carrier-based dry powder inhalation formulations	1569:1616	They hold a potential for use as critical material attributes to aid monitoring and optimization of carrier-based dry powder inhalation formulations in quality-by-design systems.
34942326	6	103	theme	drug	899:902	arg1	material					929:936	a spray-dried drug (fluticasone propionate) material	885:936	a spray-dried drug (fluticasone propionate) material	885:936	The formulations were mixtures of coarse-fine excipient (α-lactose monohydrate) blends, with different fine excipient concentrations (0.0-15.0 % w/w), and a spray-dried drug (fluticasone propionate) material.
34363222	6	0	theme	quality	725:731	arg1	characteristics					733:747	the quality characteristics	721:747	the quality characteristics of the tubers	721:761	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	2	1	theme	esculenta	134:142	arg1	cv					144:145	esculenta cv	134:145	BACKGROUND Taro (Colocasia esculenta cv.	107:146	BACKGROUND Taro (Colocasia esculenta cv.
34363222	3	2	theme	crops	213:217	arg1	one					176:178	one	176:178	one	176:178	Daikichi) is believed to be one of the earliest cultivated tuber crops and it is a staple food in many parts of the world.
34363222	3	2	theme	crops	213:217	arg1	crops					213:217	the earliest cultivated tuber crops	183:217	the earliest cultivated tuber crops	183:217	Daikichi) is believed to be one of the earliest cultivated tuber crops and it is a staple food in many parts of the world.
34363222	10	3	theme	paste	1418:1422	arg1	hardness					1371:1378	hardness	1371:1378	hardness	1371:1378	Flooding cultivation also reduced the harshness and increased the hardness and stickiness of steamed mother corm paste, generally discarded under unflooded cultivation, thus rendering it suitable for consumption.
34363222	10	3	theme	paste	1418:1422	arg1	stickiness					1384:1393	stickiness	1384:1393	stickiness	1384:1393	Flooding cultivation also reduced the harshness and increased the hardness and stickiness of steamed mother corm paste, generally discarded under unflooded cultivation, thus rendering it suitable for consumption.
34363222	11	4	theme	Controlled	1529:1538	arg1	cultivation					1549:1559	CONCLUSION Controlled flooding cultivation	1518:1559	CONCLUSION Controlled flooding cultivation	1518:1559	CONCLUSION Controlled flooding cultivation has economic advantages and the potential to improve the quality of cultivated taro.
34363222	9	5	theme	AG/AGP	1290:1295	arg1	levels					1297:1302	oxalate, nitrate ion, GABA, and AG/AGP levels	1258:1302	oxalate, nitrate ion, GABA, and AG/AGP levels	1258:1302	RESULTS Flooding cultivation increased polyphenol levels and antioxidant activity and decreased oxalate, nitrate ion, GABA, and AG/AGP levels.
34363222	3	6	theme	cultivated	196:205	arg1	crops					213:217	the earliest cultivated tuber crops	183:217	the earliest cultivated tuber crops	183:217	Daikichi) is believed to be one of the earliest cultivated tuber crops and it is a staple food in many parts of the world.
34363222	4	7	theme	side	291:294	arg1	cormels					296:302	side cormels	291:302	side cormels (daughter and granddaughter tubers)	291:338	The mother corm and side cormels (daughter and granddaughter tubers) form the major consumed parts; however, the former is rarely preferred.
34363222	6	8	theme	diseases	632:639	arg1	risk					624:627	lower risk	618:627	lower risk of diseases, weeds, and insect pests	618:664	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	8	9	theme	total	1084:1088	arg1	content					1101:1107	total polyphenol content	1084:1107	total polyphenol content	1084:1107	Their taste, color, physical properties, antioxidant activity, and starch, oxalic acid, nitrate ion, arabinogalactan (AG)/AG protein (AGP), γ-aminobutyric acid (GABA), and total polyphenol content was compared with those under unflooded cultivation.
34363222	7	10	theme	flooding	825:832	arg1	cultivation					834:844	controlled flooding cultivation	814:844	controlled flooding cultivation	814:844	In this study, the effects of controlled flooding cultivation on the quality of mother corm and side cormels were investigated.
34363222	6	11	contain	has	586:588	arg1	cultivation					574:584	flooding cultivation	565:584	flooding cultivation	565:584	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	6	11	contain	has	586:588	arg2	risk					624:627	lower risk	618:627	lower risk of diseases, weeds, and insect pests	618:664	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	6	11	contain	has	586:588	arg2	advantages					598:607	several advantages	590:607	several advantages	590:607	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	12	12	theme	©	1646:1646	arg1	2021					1648:1651	© 2021	1646:1651	© 2021	1646:1651	© 2021 The Authors.
34363222	3	13	theme	many	246:249	arg1	parts					251:255	many parts	246:255	many parts of the world	246:268	Daikichi) is believed to be one of the earliest cultivated tuber crops and it is a staple food in many parts of the world.
34363222	8	14	theme	unflooded	1139:1147	arg1	cultivation					1149:1159	unflooded cultivation	1139:1159	unflooded cultivation	1139:1159	Their taste, color, physical properties, antioxidant activity, and starch, oxalic acid, nitrate ion, arabinogalactan (AG)/AG protein (AGP), γ-aminobutyric acid (GABA), and total polyphenol content was compared with those under unflooded cultivation.
34363222	11	15	theme	cultivated	1629:1638	arg1	taro					1640:1643	cultivated taro	1629:1643	cultivated taro	1629:1643	CONCLUSION Controlled flooding cultivation has economic advantages and the potential to improve the quality of cultivated taro.
34363222	7	16	theme	cormels	885:891	arg1	quality					853:859	the quality	849:859	the quality of mother corm and side cormels	849:891	In this study, the effects of controlled flooding cultivation on the quality of mother corm and side cormels were investigated.
34363222	3	17	theme	world	264:268	arg1	parts					251:255	many parts	246:255	many parts of the world	246:268	Daikichi) is believed to be one of the earliest cultivated tuber crops and it is a staple food in many parts of the world.
34363222	4	18	theme	major	349:353	arg1	parts					364:368	the major consumed parts	345:368	the major consumed parts	345:368	The mother corm and side cormels (daughter and granddaughter tubers) form the major consumed parts; however, the former is rarely preferred.
34363222	4	19	dep	cormels	296:302	arg1	daughter					305:312	daughter	305:312	daughter	305:312	The mother corm and side cormels (daughter and granddaughter tubers) form the major consumed parts; however, the former is rarely preferred.
34363222	4	19	dep	cormels	296:302	arg1	tubers					332:337	granddaughter tubers	318:337	granddaughter tubers	318:337	The mother corm and side cormels (daughter and granddaughter tubers) form the major consumed parts; however, the former is rarely preferred.
34363222	6	20	theme	flooding	565:572	arg1	cultivation					574:584	flooding cultivation	565:584	flooding cultivation	565:584	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	0	21	theme	taro	66:69	arg1	cv					92:93	taro (Colocasia esculenta cv	66:93	taro (Colocasia esculenta cv	66:93	Effects of flooding cultivation on the composition and quality of taro (Colocasia esculenta cv.
34363222	5	22	theme	wetland-irrigated	512:528	arg1	conditions					530:539	dryland-rainfed and wetland-irrigated conditions	492:539	dryland-rainfed and wetland-irrigated conditions	492:539	Taro is mainly cultivated using either unflooded or flooding cultivation, under dryland-rainfed and wetland-irrigated conditions, respectively.
34363222	0	23	from	Effects	0:6	arg1	quality					55:61	quality	55:61	quality	55:61	Effects of flooding cultivation on the composition and quality of taro (Colocasia esculenta cv.
34363222	0	23	from	Effects	0:6	arg1	composition					39:49	composition	39:49	composition	39:49	Effects of flooding cultivation on the composition and quality of taro (Colocasia esculenta cv.
34363222	0	24	theme	Colocasia	72:80	arg1	cv					92:93	taro (Colocasia esculenta cv	66:93	taro (Colocasia esculenta cv	66:93	Effects of flooding cultivation on the composition and quality of taro (Colocasia esculenta cv.
34363222	13	25	theme	Wiley	1731:1735	arg1	Sons					1739:1742	John Wiley & Sons Ltd	1726:1746	John Wiley & Sons Ltd on behalf of Society of Chemical Industry	1726:1788	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
34363222	0	26	theme	cv	92:93	arg1	quality					55:61	quality	55:61	quality	55:61	Effects of flooding cultivation on the composition and quality of taro (Colocasia esculenta cv.
34363222	0	26	theme	cv	92:93	arg1	composition					39:49	composition	39:49	composition	39:49	Effects of flooding cultivation on the composition and quality of taro (Colocasia esculenta cv.
34363222	9	27	theme	RESULTS	1162:1168	arg1	cultivation					1179:1189	RESULTS Flooding cultivation	1162:1189	RESULTS Flooding cultivation	1162:1189	RESULTS Flooding cultivation increased polyphenol levels and antioxidant activity and decreased oxalate, nitrate ion, GABA, and AG/AGP levels.
34363222	11	28	contain	has	1561:1563	arg1	cultivation					1549:1559	CONCLUSION Controlled flooding cultivation	1518:1559	CONCLUSION Controlled flooding cultivation	1518:1559	CONCLUSION Controlled flooding cultivation has economic advantages and the potential to improve the quality of cultivated taro.
34363222	11	28	contain	has	1561:1563	arg2	potential					1593:1601	the potential to improve the quality of cultivated taro	1589:1643	the potential to improve the quality of cultivated taro	1589:1643	CONCLUSION Controlled flooding cultivation has economic advantages and the potential to improve the quality of cultivated taro.
34363222	11	28	contain	has	1561:1563	arg2	advantages					1574:1583	economic advantages	1565:1583	economic advantages	1565:1583	CONCLUSION Controlled flooding cultivation has economic advantages and the potential to improve the quality of cultivated taro.
34363222	6	29	from	effects	710:716	arg1	characteristics					733:747	the quality characteristics	721:747	the quality characteristics of the tubers	721:761	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	12	30	dep	Authors	1657:1663	arg1	2021					1648:1651	© 2021	1646:1651	© 2021	1646:1651	© 2021 The Authors.
34363222	8	31	theme	antioxidant	953:963	arg1	activity					965:972	antioxidant activity	953:972	antioxidant activity	953:972	Their taste, color, physical properties, antioxidant activity, and starch, oxalic acid, nitrate ion, arabinogalactan (AG)/AG protein (AGP), γ-aminobutyric acid (GABA), and total polyphenol content was compared with those under unflooded cultivation.
34363222	5	32	theme	dryland-rainfed	492:506	arg1	conditions					530:539	dryland-rainfed and wetland-irrigated conditions	492:539	dryland-rainfed and wetland-irrigated conditions	492:539	Taro is mainly cultivated using either unflooded or flooding cultivation, under dryland-rainfed and wetland-irrigated conditions, respectively.
34363222	6	33	theme	lower	618:622	arg1	risk					624:627	lower risk	618:627	lower risk of diseases, weeds, and insect pests	618:664	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	0	34	theme	flooding	11:18	arg1	cultivation					20:30	flooding cultivation	11:30	flooding cultivation	11:30	Effects of flooding cultivation on the composition and quality of taro (Colocasia esculenta cv.
34363222	9	35	theme	polyphenol	1201:1210	arg1	levels					1212:1217	polyphenol levels	1201:1217	polyphenol levels	1201:1217	RESULTS Flooding cultivation increased polyphenol levels and antioxidant activity and decreased oxalate, nitrate ion, GABA, and AG/AGP levels.
34363222	0	36	dep	composition	39:49	arg1	the					35:37	the	35:37	the	35:37	Effects of flooding cultivation on the composition and quality of taro (Colocasia esculenta cv.
34363222	4	37	theme	mother	275:280	arg1	corm					282:285	The mother corm	271:285	The mother corm	271:285	The mother corm and side cormels (daughter and granddaughter tubers) form the major consumed parts; however, the former is rarely preferred.
34363222	8	38	theme	oxalic	987:992	arg1	acid					994:997	oxalic acid	987:997	oxalic acid	987:997	Their taste, color, physical properties, antioxidant activity, and starch, oxalic acid, nitrate ion, arabinogalactan (AG)/AG protein (AGP), γ-aminobutyric acid (GABA), and total polyphenol content was compared with those under unflooded cultivation.
34363222	6	39	theme	tubers	756:761	arg1	characteristics					733:747	the quality characteristics	721:747	the quality characteristics of the tubers	721:761	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	7	40	theme	controlled	814:823	arg1	cultivation					834:844	controlled flooding cultivation	814:844	controlled flooding cultivation	814:844	In this study, the effects of controlled flooding cultivation on the quality of mother corm and side cormels were investigated.
34363222	3	41	from	food	238:241	arg1	parts					251:255	many parts	246:255	many parts of the world	246:268	Daikichi) is believed to be one of the earliest cultivated tuber crops and it is a staple food in many parts of the world.
34363222	10	42	theme	corm	1413:1416	arg1	paste					1418:1422	steamed mother corm paste	1398:1422	steamed mother corm paste	1398:1422	Flooding cultivation also reduced the harshness and increased the hardness and stickiness of steamed mother corm paste, generally discarded under unflooded cultivation, thus rendering it suitable for consumption.
34363222	6	43	theme	insect	653:658	arg1	pests					660:664	insect pests	653:664	insect pests	653:664	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	10	44	theme	steamed	1398:1404	arg1	paste					1418:1422	steamed mother corm paste	1398:1422	steamed mother corm paste	1398:1422	Flooding cultivation also reduced the harshness and increased the hardness and stickiness of steamed mother corm paste, generally discarded under unflooded cultivation, thus rendering it suitable for consumption.
34363222	11	45	theme	CONCLUSION	1518:1527	arg1	cultivation					1549:1559	CONCLUSION Controlled flooding cultivation	1518:1559	CONCLUSION Controlled flooding cultivation	1518:1559	CONCLUSION Controlled flooding cultivation has economic advantages and the potential to improve the quality of cultivated taro.
34363222	9	46	theme	ion	1275:1277	arg1	levels					1297:1302	oxalate, nitrate ion, GABA, and AG/AGP levels	1258:1302	oxalate, nitrate ion, GABA, and AG/AGP levels	1258:1302	RESULTS Flooding cultivation increased polyphenol levels and antioxidant activity and decreased oxalate, nitrate ion, GABA, and AG/AGP levels.
34363222	8	47	theme	arabinogalactan	1013:1027	arg1	AGP					1046:1048	AGP	1046:1048	AGP	1046:1048	Their taste, color, physical properties, antioxidant activity, and starch, oxalic acid, nitrate ion, arabinogalactan (AG)/AG protein (AGP), γ-aminobutyric acid (GABA), and total polyphenol content was compared with those under unflooded cultivation.
34363222	8	47	theme	arabinogalactan	1013:1027	arg1	protein					1037:1043	arabinogalactan (AG)/AG protein	1013:1043	arabinogalactan (AG)/AG protein (AGP)	1013:1049	Their taste, color, physical properties, antioxidant activity, and starch, oxalic acid, nitrate ion, arabinogalactan (AG)/AG protein (AGP), γ-aminobutyric acid (GABA), and total polyphenol content was compared with those under unflooded cultivation.
34363222	3	48	theme	earliest	187:194	arg1	crops					213:217	the earliest cultivated tuber crops	183:217	the earliest cultivated tuber crops	183:217	Daikichi) is believed to be one of the earliest cultivated tuber crops and it is a staple food in many parts of the world.
34363222	4	49	theme	granddaughter	318:330	arg1	tubers					332:337	granddaughter tubers	318:337	granddaughter tubers	318:337	The mother corm and side cormels (daughter and granddaughter tubers) form the major consumed parts; however, the former is rarely preferred.
34363222	9	50	theme	GABA	1280:1283	arg1	levels					1297:1302	oxalate, nitrate ion, GABA, and AG/AGP levels	1258:1302	oxalate, nitrate ion, GABA, and AG/AGP levels	1258:1302	RESULTS Flooding cultivation increased polyphenol levels and antioxidant activity and decreased oxalate, nitrate ion, GABA, and AG/AGP levels.
34363222	8	51	theme	/AG	1033:1035	arg1	AGP					1046:1048	AGP	1046:1048	AGP	1046:1048	Their taste, color, physical properties, antioxidant activity, and starch, oxalic acid, nitrate ion, arabinogalactan (AG)/AG protein (AGP), γ-aminobutyric acid (GABA), and total polyphenol content was compared with those under unflooded cultivation.
34363222	8	51	theme	/AG	1033:1035	arg1	protein					1037:1043	arabinogalactan (AG)/AG protein	1013:1043	arabinogalactan (AG)/AG protein (AGP)	1013:1049	Their taste, color, physical properties, antioxidant activity, and starch, oxalic acid, nitrate ion, arabinogalactan (AG)/AG protein (AGP), γ-aminobutyric acid (GABA), and total polyphenol content was compared with those under unflooded cultivation.
34363222	5	52	dep	unflooded	451:459	arg1	cultivation					473:483	cultivation	473:483	cultivation	473:483	Taro is mainly cultivated using either unflooded or flooding cultivation, under dryland-rainfed and wetland-irrigated conditions, respectively.
34363222	11	53	theme	flooding	1540:1547	arg1	cultivation					1549:1559	CONCLUSION Controlled flooding cultivation	1518:1559	CONCLUSION Controlled flooding cultivation	1518:1559	CONCLUSION Controlled flooding cultivation has economic advantages and the potential to improve the quality of cultivated taro.
34363222	3	54	theme	tuber	207:211	arg1	crops					213:217	the earliest cultivated tuber crops	183:217	the earliest cultivated tuber crops	183:217	Daikichi) is believed to be one of the earliest cultivated tuber crops and it is a staple food in many parts of the world.
34363222	10	55	theme	unflooded	1451:1459	arg1	cultivation					1461:1471	unflooded cultivation	1451:1471	unflooded cultivation	1451:1471	Flooding cultivation also reduced the harshness and increased the hardness and stickiness of steamed mother corm paste, generally discarded under unflooded cultivation, thus rendering it suitable for consumption.
34363222	6	56	theme	tuber	693:697	arg1	yield					699:703	increased tuber yield	683:703	increased tuber yield	683:703	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	7	57	theme	mother	864:869	arg1	corm					871:874	mother corm	864:874	mother corm	864:874	In this study, the effects of controlled flooding cultivation on the quality of mother corm and side cormels were investigated.
34363222	3	58	theme	staple	231:236	arg1	it					223:224	it	223:224	it	223:224	Daikichi) is believed to be one of the earliest cultivated tuber crops and it is a staple food in many parts of the world.
34363222	3	58	theme	staple	231:236	arg1	food					238:241	a staple food	229:241	a staple food in many parts of the world	229:268	Daikichi) is believed to be one of the earliest cultivated tuber crops and it is a staple food in many parts of the world.
34363222	8	59	theme	polyphenol	1090:1099	arg1	content					1101:1107	total polyphenol content	1084:1107	total polyphenol content	1084:1107	Their taste, color, physical properties, antioxidant activity, and starch, oxalic acid, nitrate ion, arabinogalactan (AG)/AG protein (AGP), γ-aminobutyric acid (GABA), and total polyphenol content was compared with those under unflooded cultivation.
34363222	8	60	theme	γ-aminobutyric	1052:1065	arg1	acid					1067:1070	γ-aminobutyric acid	1052:1070	γ-aminobutyric acid (GABA)	1052:1077	Their taste, color, physical properties, antioxidant activity, and starch, oxalic acid, nitrate ion, arabinogalactan (AG)/AG protein (AGP), γ-aminobutyric acid (GABA), and total polyphenol content was compared with those under unflooded cultivation.
34363222	8	60	theme	γ-aminobutyric	1052:1065	arg1	GABA					1073:1076	GABA	1073:1076	GABA	1073:1076	Their taste, color, physical properties, antioxidant activity, and starch, oxalic acid, nitrate ion, arabinogalactan (AG)/AG protein (AGP), γ-aminobutyric acid (GABA), and total polyphenol content was compared with those under unflooded cultivation.
34363222	4	61	theme	consumed	355:362	arg1	parts					364:368	the major consumed parts	345:368	the major consumed parts	345:368	The mother corm and side cormels (daughter and granddaughter tubers) form the major consumed parts; however, the former is rarely preferred.
34363222	6	62	theme	several	590:596	arg1	risk					624:627	lower risk	618:627	lower risk of diseases, weeds, and insect pests	618:664	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	6	62	theme	several	590:596	arg1	advantages					598:607	several advantages	590:607	several advantages	590:607	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	11	63	theme	taro	1640:1643	arg1	quality					1618:1624	the quality	1614:1624	the quality of cultivated taro	1614:1643	CONCLUSION Controlled flooding cultivation has economic advantages and the potential to improve the quality of cultivated taro.
34363222	10	64	dep	hardness	1371:1378	arg1	the					1367:1369	the	1367:1369	the	1367:1369	Flooding cultivation also reduced the harshness and increased the hardness and stickiness of steamed mother corm paste, generally discarded under unflooded cultivation, thus rendering it suitable for consumption.
34363222	7	65	theme	side	880:883	arg1	cormels					885:891	side cormels	880:891	side cormels	880:891	In this study, the effects of controlled flooding cultivation on the quality of mother corm and side cormels were investigated.
34363222	0	66	theme	esculenta	82:90	arg1	cv					92:93	taro (Colocasia esculenta cv	66:93	taro (Colocasia esculenta cv	66:93	Effects of flooding cultivation on the composition and quality of taro (Colocasia esculenta cv.
34363222	8	67	theme	physical	932:939	arg1	properties					941:950	physical properties	932:950	physical properties	932:950	Their taste, color, physical properties, antioxidant activity, and starch, oxalic acid, nitrate ion, arabinogalactan (AG)/AG protein (AGP), γ-aminobutyric acid (GABA), and total polyphenol content was compared with those under unflooded cultivation.
34363222	7	68	theme	corm	871:874	arg1	quality					853:859	the quality	849:859	the quality of mother corm and side cormels	849:891	In this study, the effects of controlled flooding cultivation on the quality of mother corm and side cormels were investigated.
34363222	6	69	theme	weeds	642:646	arg1	risk					624:627	lower risk	618:627	lower risk of diseases, weeds, and insect pests	618:664	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	13	70	theme	John	1726:1729	arg1	Sons					1739:1742	John Wiley & Sons Ltd	1726:1746	John Wiley & Sons Ltd on behalf of Society of Chemical Industry	1726:1788	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
34363222	13	71	theme	&	1737:1737	arg1	Sons					1739:1742	John Wiley & Sons Ltd	1726:1746	John Wiley & Sons Ltd on behalf of Society of Chemical Industry	1726:1788	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
34363222	9	72	theme	Flooding	1170:1177	arg1	cultivation					1179:1189	RESULTS Flooding cultivation	1162:1189	RESULTS Flooding cultivation	1162:1189	RESULTS Flooding cultivation increased polyphenol levels and antioxidant activity and decreased oxalate, nitrate ion, GABA, and AG/AGP levels.
34363222	10	73	theme	Flooding	1305:1312	arg1	cultivation					1314:1324	Flooding cultivation	1305:1324	Flooding cultivation	1305:1324	Flooding cultivation also reduced the harshness and increased the hardness and stickiness of steamed mother corm paste, generally discarded under unflooded cultivation, thus rendering it suitable for consumption.
34363222	7	74	from	effects	803:809	arg1	quality					853:859	the quality	849:859	the quality of mother corm and side cormels	849:891	In this study, the effects of controlled flooding cultivation on the quality of mother corm and side cormels were investigated.
34363222	0	75	theme	cultivation	20:30	arg1	Effects					0:6	Effects	0:6	Effects of flooding cultivation on the composition and quality of taro (Colocasia esculenta cv	0:93	Effects of flooding cultivation on the composition and quality of taro (Colocasia esculenta cv.
34363222	7	76	theme	cultivation	834:844	arg1	effects					803:809	the effects	799:809	the effects of controlled flooding cultivation on the quality of mother corm and side cormels	799:891	In this study, the effects of controlled flooding cultivation on the quality of mother corm and side cormels were investigated.
34363222	11	77	theme	economic	1565:1572	arg1	advantages					1574:1583	economic advantages	1565:1583	economic advantages	1565:1583	CONCLUSION Controlled flooding cultivation has economic advantages and the potential to improve the quality of cultivated taro.
34363222	13	78	theme	Chemical	1772:1779	arg1	Industry					1781:1788	Chemical Industry	1772:1788	Chemical Industry	1772:1788	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
34363222	6	79	theme	increased	683:691	arg1	yield					699:703	increased tuber yield	683:703	increased tuber yield	683:703	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	9	80	theme	antioxidant	1223:1233	arg1	activity					1235:1242	antioxidant activity	1223:1242	antioxidant activity	1223:1242	RESULTS Flooding cultivation increased polyphenol levels and antioxidant activity and decreased oxalate, nitrate ion, GABA, and AG/AGP levels.
34363222	13	81	theme	Science	1681:1687	arg1	Journal					1666:1672	Journal	1666:1672	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.	1666:1789	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
34363222	13	82	dep	Sons	1739:1742	arg1	Ltd					1744:1746	Ltd	1744:1746	Ltd	1744:1746	Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
34363222	2	83	dep	BACKGROUND	107:116	arg1	cv					144:145	esculenta cv	134:145	BACKGROUND Taro (Colocasia esculenta cv.	107:146	BACKGROUND Taro (Colocasia esculenta cv.
34363222	2	83	dep	BACKGROUND	107:116	arg1	Colocasia					124:132	Colocasia	124:132	Colocasia	124:132	BACKGROUND Taro (Colocasia esculenta cv.
34363222	8	84	theme	nitrate	1000:1006	arg1	ion					1008:1010	nitrate ion	1000:1010	nitrate ion	1000:1010	Their taste, color, physical properties, antioxidant activity, and starch, oxalic acid, nitrate ion, arabinogalactan (AG)/AG protein (AGP), γ-aminobutyric acid (GABA), and total polyphenol content was compared with those under unflooded cultivation.
34363222	6	85	theme	pests	660:664	arg1	risk					624:627	lower risk	618:627	lower risk of diseases, weeds, and insect pests	618:664	Although flooding cultivation has several advantages, such as lower risk of diseases, weeds, and insect pests, contributing to increased tuber yield, its effects on the quality characteristics of the tubers are largely unknown.
34363222	9	86	theme	oxalate	1258:1264	arg1	levels					1297:1302	oxalate, nitrate ion, GABA, and AG/AGP levels	1258:1302	oxalate, nitrate ion, GABA, and AG/AGP levels	1258:1302	RESULTS Flooding cultivation increased polyphenol levels and antioxidant activity and decreased oxalate, nitrate ion, GABA, and AG/AGP levels.
34363222	10	87	theme	mother	1406:1411	arg1	paste					1418:1422	steamed mother corm paste	1398:1422	steamed mother corm paste	1398:1422	Flooding cultivation also reduced the harshness and increased the hardness and stickiness of steamed mother corm paste, generally discarded under unflooded cultivation, thus rendering it suitable for consumption.
34363222	9	88	theme	nitrate	1267:1273	arg1	ion					1275:1277	nitrate ion	1267:1277	nitrate ion	1267:1277	RESULTS Flooding cultivation increased polyphenol levels and antioxidant activity and decreased oxalate, nitrate ion, GABA, and AG/AGP levels.
33415632	2	0	from	increase	420:427	arg1	pollution					446:454	environmental pollution	432:454	environmental pollution with major consequences	432:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	12	1	theme	millet	2027:2032	arg1	briquettes					2034:2043	The sorghum panicle-pearl millet briquettes	2001:2043	The sorghum panicle-pearl millet briquettes	2001:2043	The sorghum panicle-pearl millet briquettes have better calorific value than pongamia-tamarind shells, and they produce better heating values.
33415632	13	2	theme	agro	2228:2231	arg1	wastes					2233:2238	agro wastes	2228:2238	agro wastes	2228:2238	Hence, the prepared biomass briquettes are potentially good fuels that derived from agro wastes.
33415632	11	3	theme	fixed	1936:1940	arg1	composition					1949:1959	more fixed carbon composition	1931:1959	more fixed carbon composition	1931:1959	By the cause of more fixed carbon composition, there exists lack in hydrogen content.
33415632	2	4	theme	increased	315:323	arg1	problems					355:362	increased manifold causing twin serious problems	315:362	increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences	315:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	2	4	theme	increased	315:323	arg1	depletion					372:380	depletion	372:380	depletion of limited source of fossil fuels and increase in environmental pollution with major consequences	372:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	4	5	theme	water	833:837	arg1	content					839:845	water content	833:845	water content	833:845	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	13	6	theme	prepared	2155:2162	arg1	fuels					2204:2208	potentially good fuels that derived from agro wastes	2187:2238	potentially good fuels that derived from agro wastes	2187:2238	Hence, the prepared biomass briquettes are potentially good fuels that derived from agro wastes.
33415632	13	6	theme	prepared	2155:2162	arg1	briquettes					2172:2181	the prepared biomass briquettes	2151:2181	the prepared biomass briquettes	2151:2181	Hence, the prepared biomass briquettes are potentially good fuels that derived from agro wastes.
33415632	2	7	theme	fuels	305:309	arg1	Now-a-days					273:282	Now-a-days	273:282	Now-a-days	273:282	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	2	7	theme	fuels	305:309	arg1	usage					289:293	the usage	285:293	the usage of fossil fuels	285:309	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	14	8	theme	biomass	2305:2311	arg1	briquettes					2313:2322	the other biomass briquettes	2295:2322	the other biomass briquettes	2295:2322	Likewise, the determined parameters are compared with the other biomass briquettes.
33415632	11	9	theme	composition	1949:1959	arg1	cause					1922:1926	the cause	1918:1926	the cause of more fixed carbon composition	1918:1959	By the cause of more fixed carbon composition, there exists lack in hydrogen content.
33415632	2	10	with	pollution	446:454	arg1	consequences					467:478	major consequences	461:478	major consequences	461:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	4	11	theme	proximate	804:812	arg1	parameters					814:823	The proximate parameters	800:823	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter	800:893	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	4	11	theme	proximate	804:812	arg1	ash					871:873	ash	871:873	ash	871:873	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	4	11	theme	proximate	804:812	arg1	matter					888:893	volatile matter	879:893	volatile matter	879:893	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	4	11	theme	proximate	804:812	arg1	content					839:845	water content	833:845	water content	833:845	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	4	11	theme	proximate	804:812	arg1	level					848:852	level	848:852	level of fixed carbon	848:868	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	0	12	from	millets	73:79	arg1	characteristics					11:25	Combustion characteristics	0:25	Combustion characteristics of briquette fuels from sorghum panicle-pearl millets using cassava starch binder.	0:108	Combustion characteristics of briquette fuels from sorghum panicle-pearl millets using cassava starch binder.
33415632	10	13	theme	nitrogen	1835:1842	arg1	absence					1844:1850	nitrogen absence	1835:1850	nitrogen absence	1835:1850	The occurrence of nitrogen absence is due to non-availability of NOx emissions during combustion.
33415632	3	14	theme	cassava	680:686	arg1	starch					688:693	cassava starch	680:693	cassava starch	680:693	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	3	14	theme	cassava	680:686	arg1	binder					700:705	a binder	698:705	a binder with a planned compacting pressure level (200 kN)	698:755	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	1	15	theme	agricultural	129:140	arg1	wastes					142:147	agricultural wastes	129:147	agricultural wastes	129:147	The utilization of agricultural wastes is an attractive and viable option to reduce the environmental pollution and reverse the over-exploitation of fossil fuels.
33415632	3	16	with	binder	700:705	arg1	200 kN					749:754	200 kN	749:754	200 kN	749:754	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	3	16	with	binder	700:705	arg1	level					742:746	a planned compacting pressure level	712:746	a planned compacting pressure level (200 kN)	712:755	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	6	17	theme	optimum	1290:1296	arg1	values					1306:1311	optimum heating values	1290:1311	optimum heating values	1290:1311	Weight loss and optimum heating values of the samples were measured by adopting differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) respectively.
33415632	8	18	theme	sorghum	1595:1601	arg1	briquettes					1624:1633	sorghum panicle-pearl millet briquettes	1595:1633	sorghum panicle-pearl millet briquettes	1595:1633	In comparison with pongamia-tamarind shell, sorghum panicle-pearl millet briquettes have better fuel properties.
33415632	1	19	theme	attractive	155:164	arg1	option					177:182	an attractive and viable option	152:182	an attractive and viable option to reduce the environmental pollution and reverse the over-exploitation of fossil fuels	152:270	The utilization of agricultural wastes is an attractive and viable option to reduce the environmental pollution and reverse the over-exploitation of fossil fuels.
33415632	1	19	theme	attractive	155:164	arg1	utilization					114:124	The utilization	110:124	The utilization of agricultural wastes	110:147	The utilization of agricultural wastes is an attractive and viable option to reduce the environmental pollution and reverse the over-exploitation of fossil fuels.
33415632	4	20	theme	volatile	879:886	arg1	matter					888:893	volatile matter	879:893	volatile matter	879:893	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	0	21	theme	cassava	87:93	arg1	binder					102:107	cassava starch binder	87:107	cassava starch binder	87:107	Combustion characteristics of briquette fuels from sorghum panicle-pearl millets using cassava starch binder.
33415632	1	22	theme	viable	170:175	arg1	option					177:182	an attractive and viable option	152:182	an attractive and viable option to reduce the environmental pollution and reverse the over-exploitation of fossil fuels	152:270	The utilization of agricultural wastes is an attractive and viable option to reduce the environmental pollution and reverse the over-exploitation of fossil fuels.
33415632	1	22	theme	viable	170:175	arg1	utilization					114:124	The utilization	110:124	The utilization of agricultural wastes	110:147	The utilization of agricultural wastes is an attractive and viable option to reduce the environmental pollution and reverse the over-exploitation of fossil fuels.
33415632	3	23	theme	hydraulic	770:778	arg1	method					792:797	hydraulic compression method	770:797	hydraulic compression method	770:797	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	10	24	theme	emissions	1886:1894	arg1	non-availability					1862:1877	non-availability	1862:1877	non-availability of NOx emissions during combustion	1862:1912	The occurrence of nitrogen absence is due to non-availability of NOx emissions during combustion.
33415632	3	25	theme	compacting	722:731	arg1	200 kN					749:754	200 kN	749:754	200 kN	749:754	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	3	25	theme	compacting	722:731	arg1	level					742:746	a planned compacting pressure level	712:746	a planned compacting pressure level (200 kN)	712:755	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	6	26	theme	Weight	1274:1279	arg1	loss					1281:1284	Weight loss	1274:1284	Weight loss	1274:1284	Weight loss and optimum heating values of the samples were measured by adopting differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) respectively.
33415632	4	27	theme	carbon	863:868	arg1	ash					871:873	ash	871:873	ash	871:873	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	4	27	theme	carbon	863:868	arg1	level					848:852	level	848:852	level of fixed carbon	848:868	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	4	27	theme	carbon	863:868	arg1	content					839:845	water content	833:845	water content	833:845	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	4	27	theme	carbon	863:868	arg1	matter					888:893	volatile matter	879:893	volatile matter	879:893	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	6	28	theme	differential	1354:1365	arg1	DSC					1389:1391	DSC	1389:1391	DSC	1389:1391	Weight loss and optimum heating values of the samples were measured by adopting differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) respectively.
33415632	6	28	theme	differential	1354:1365	arg1	calorimetry					1376:1386	differential scanning calorimetry	1354:1386	differential scanning calorimetry (DSC)	1354:1392	Weight loss and optimum heating values of the samples were measured by adopting differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) respectively.
33415632	9	29	theme	shell	1686:1690	arg1	fuel					1692:1695	The pongamia-tamarind shell fuel	1664:1695	The pongamia-tamarind shell fuel	1664:1695	The pongamia-tamarind shell fuel has nitrogen and hydrogen whereas sorghum panicle-pearl millet has no identities on both nitrogen and hydrogen content.
33415632	2	30	theme	fossil	403:408	arg1	fuels					410:414	fossil fuels	403:414	fossil fuels	403:414	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	8	31	theme	fuel	1647:1650	arg1	properties					1652:1661	better fuel properties	1640:1661	better fuel properties	1640:1661	In comparison with pongamia-tamarind shell, sorghum panicle-pearl millet briquettes have better fuel properties.
33415632	2	32	theme	major	461:465	arg1	consequences					467:478	major consequences	461:478	major consequences	461:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	2	33	theme	source	393:398	arg1	depletion					372:380	depletion	372:380	depletion of limited source of fossil fuels and increase in environmental pollution with major consequences	372:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	0	34	theme	Combustion	0:9	arg1	characteristics					11:25	Combustion characteristics	0:25	Combustion characteristics of briquette fuels from sorghum panicle-pearl millets using cassava starch binder.	0:108	Combustion characteristics of briquette fuels from sorghum panicle-pearl millets using cassava starch binder.
33415632	12	35	theme	better	2121:2126	arg1	values					2136:2141	better heating values	2121:2141	better heating values	2121:2141	The sorghum panicle-pearl millet briquettes have better calorific value than pongamia-tamarind shells, and they produce better heating values.
33415632	0	36	theme	fuels	40:44	arg1	characteristics					11:25	Combustion characteristics	0:25	Combustion characteristics of briquette fuels from sorghum panicle-pearl millets using cassava starch binder.	0:108	Combustion characteristics of briquette fuels from sorghum panicle-pearl millets using cassava starch binder.
33415632	7	37	theme	produced	1514:1521	arg1	briquettes					1523:1532	all the produced briquettes	1506:1532	all the produced briquettes	1506:1532	In addition to that, the density and compressive strength of all the produced briquettes were determined.
33415632	2	38	from	source	393:398	arg1	pollution					446:454	environmental pollution	432:454	environmental pollution with major consequences	432:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	12	39	theme	pongamia-tamarind	2078:2094	arg1	shells					2096:2101	pongamia-tamarind shells	2078:2101	pongamia-tamarind shells	2078:2101	The sorghum panicle-pearl millet briquettes have better calorific value than pongamia-tamarind shells, and they produce better heating values.
33415632	9	40	theme	panicle-pearl	1739:1751	arg1	millet					1753:1758	sorghum panicle-pearl millet	1731:1758	sorghum panicle-pearl millet	1731:1758	The pongamia-tamarind shell fuel has nitrogen and hydrogen whereas sorghum panicle-pearl millet has no identities on both nitrogen and hydrogen content.
33415632	0	41	theme	sorghum	51:57	arg1	millets					73:79	sorghum panicle-pearl millets	51:79	sorghum panicle-pearl millets using cassava starch binder	51:107	Combustion characteristics of briquette fuels from sorghum panicle-pearl millets using cassava starch binder.
33415632	4	42	theme	standard	967:974	arg1	procedures					976:985	standard procedures	967:985	standard procedures	967:985	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	2	43	theme	twin	342:345	arg1	problems					355:362	increased manifold causing twin serious problems	315:362	increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences	315:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	2	43	theme	twin	342:345	arg1	depletion					372:380	depletion	372:380	depletion of limited source of fossil fuels and increase in environmental pollution with major consequences	372:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	12	44	theme	better	2050:2055	arg1	value					2067:2071	better calorific value	2050:2071	better calorific value	2050:2071	The sorghum panicle-pearl millet briquettes have better calorific value than pongamia-tamarind shells, and they produce better heating values.
33415632	3	45	theme	sorghum	527:533	arg1	SP					545:546	SP	545:546	SP	545:546	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	3	45	theme	sorghum	527:533	arg1	panicles					535:542	sorghum panicles	527:542	sorghum panicles (SP)	527:547	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	1	46	theme	fuels	266:270	arg1	over-exploitation					238:254	the over-exploitation	234:254	the over-exploitation of fossil fuels	234:270	The utilization of agricultural wastes is an attractive and viable option to reduce the environmental pollution and reverse the over-exploitation of fossil fuels.
33415632	13	47	theme	good	2199:2202	arg1	fuels					2204:2208	potentially good fuels that derived from agro wastes	2187:2238	potentially good fuels that derived from agro wastes	2187:2238	Hence, the prepared biomass briquettes are potentially good fuels that derived from agro wastes.
33415632	13	47	theme	good	2199:2202	arg1	briquettes					2172:2181	the prepared biomass briquettes	2151:2181	the prepared biomass briquettes	2151:2181	Hence, the prepared biomass briquettes are potentially good fuels that derived from agro wastes.
33415632	9	48	contain	has	1760:1762	arg2	identities					1767:1776	no identities	1764:1776	no identities	1764:1776	The pongamia-tamarind shell fuel has nitrogen and hydrogen whereas sorghum panicle-pearl millet has no identities on both nitrogen and hydrogen content.
33415632	9	48	contain	has	1760:1762	arg1	millet					1753:1758	sorghum panicle-pearl millet	1731:1758	sorghum panicle-pearl millet	1731:1758	The pongamia-tamarind shell fuel has nitrogen and hydrogen whereas sorghum panicle-pearl millet has no identities on both nitrogen and hydrogen content.
33415632	12	49	theme	panicle-pearl	2013:2025	arg1	briquettes					2034:2043	The sorghum panicle-pearl millet briquettes	2001:2043	The sorghum panicle-pearl millet briquettes	2001:2043	The sorghum panicle-pearl millet briquettes have better calorific value than pongamia-tamarind shells, and they produce better heating values.
33415632	2	50	theme	fossil	298:303	arg1	fuels					305:309	fossil fuels	298:309	fossil fuels	298:309	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	7	51	dep	density	1470:1476	arg1	the					1466:1468	the	1466:1468	the	1466:1468	In addition to that, the density and compressive strength of all the produced briquettes were determined.
33415632	8	52	theme	millet	1617:1622	arg1	briquettes					1624:1633	sorghum panicle-pearl millet briquettes	1595:1633	sorghum panicle-pearl millet briquettes	1595:1633	In comparison with pongamia-tamarind shell, sorghum panicle-pearl millet briquettes have better fuel properties.
33415632	4	53	dep	Society	926:932	arg1	procedures					976:985	standard procedures	967:985	standard procedures	967:985	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	2	54	theme	manifold	325:332	arg1	problems					355:362	increased manifold causing twin serious problems	315:362	increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences	315:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	2	54	theme	manifold	325:332	arg1	depletion					372:380	depletion	372:380	depletion of limited source of fossil fuels and increase in environmental pollution with major consequences	372:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	9	55	dep	nitrogen	1786:1793	arg1	content					1808:1814	content	1808:1814	content	1808:1814	The pongamia-tamarind shell fuel has nitrogen and hydrogen whereas sorghum panicle-pearl millet has no identities on both nitrogen and hydrogen content.
33415632	3	56	theme	pearl	553:557	arg1	millet					559:564	pearl millet	553:564	pearl millet (PM)	553:569	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	3	56	theme	pearl	553:557	arg1	PM					567:568	PM	567:568	PM	567:568	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	1	57	theme	environmental	198:210	arg1	pollution					212:220	the environmental pollution	194:220	the environmental pollution	194:220	The utilization of agricultural wastes is an attractive and viable option to reduce the environmental pollution and reverse the over-exploitation of fossil fuels.
33415632	11	58	from	lack	1975:1978	arg1	content					1992:1998	hydrogen content	1983:1998	hydrogen content	1983:1998	By the cause of more fixed carbon composition, there exists lack in hydrogen content.
33415632	11	59	theme	carbon	1942:1947	arg1	composition					1949:1959	more fixed carbon composition	1931:1959	more fixed carbon composition	1931:1959	By the cause of more fixed carbon composition, there exists lack in hydrogen content.
33415632	13	60	theme	biomass	2164:2170	arg1	fuels					2204:2208	potentially good fuels that derived from agro wastes	2187:2238	potentially good fuels that derived from agro wastes	2187:2238	Hence, the prepared biomass briquettes are potentially good fuels that derived from agro wastes.
33415632	13	60	theme	biomass	2164:2170	arg1	briquettes					2172:2181	the prepared biomass briquettes	2151:2181	the prepared biomass briquettes	2151:2181	Hence, the prepared biomass briquettes are potentially good fuels that derived from agro wastes.
33415632	3	61	theme	different	576:584	arg1	100:0					594:598	100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100	594:671	100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100	594:671	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	3	61	theme	different	576:584	arg1	ratios					586:591	different ratios	576:591	different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100)	576:672	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	14	62	theme	other	2299:2303	arg1	briquettes					2313:2322	the other biomass briquettes	2295:2322	the other biomass briquettes	2295:2322	Likewise, the determined parameters are compared with the other biomass briquettes.
33415632	6	63	theme	samples	1320:1326	arg1	values					1306:1311	optimum heating values	1290:1311	optimum heating values	1290:1311	Weight loss and optimum heating values of the samples were measured by adopting differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) respectively.
33415632	6	63	theme	samples	1320:1326	arg1	loss					1281:1284	Weight loss	1274:1284	Weight loss	1274:1284	Weight loss and optimum heating values of the samples were measured by adopting differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) respectively.
33415632	10	64	theme	absence	1844:1850	arg1	due					1855:1857	due	1855:1857	due	1855:1857	The occurrence of nitrogen absence is due to non-availability of NOx emissions during combustion.
33415632	10	64	theme	absence	1844:1850	arg1	occurrence					1821:1830	The occurrence	1817:1830	The occurrence of nitrogen absence	1817:1850	The occurrence of nitrogen absence is due to non-availability of NOx emissions during combustion.
33415632	5	65	theme	briquette	1255:1263	arg1	samples					1265:1271	all the briquette samples	1247:1271	all the briquette samples	1247:1271	The elemental analyses (SEM/EDAX) which include carbon (C), oxygen (O), potassium (K), calcium (Ca), chlorine (Cl), sulphur (S), phosphorus (P), aluminium (Al), silicon (Si), magnesium (Mg), cobalt (Co), iron (Fe), zinc (Zn) and sodium (K) were determined in all the briquette samples.
33415632	8	66	theme	pongamia-tamarind	1570:1586	arg1	shell					1588:1592	pongamia-tamarind shell	1570:1592	pongamia-tamarind shell	1570:1592	In comparison with pongamia-tamarind shell, sorghum panicle-pearl millet briquettes have better fuel properties.
33415632	8	67	with	comparison	1554:1563	arg1	shell					1588:1592	pongamia-tamarind shell	1570:1592	pongamia-tamarind shell	1570:1592	In comparison with pongamia-tamarind shell, sorghum panicle-pearl millet briquettes have better fuel properties.
33415632	12	68	contain	have	2045:2048	arg1	briquettes					2034:2043	The sorghum panicle-pearl millet briquettes	2001:2043	The sorghum panicle-pearl millet briquettes	2001:2043	The sorghum panicle-pearl millet briquettes have better calorific value than pongamia-tamarind shells, and they produce better heating values.
33415632	12	68	contain	have	2045:2048	arg2	value					2067:2071	better calorific value	2050:2071	better calorific value	2050:2071	The sorghum panicle-pearl millet briquettes have better calorific value than pongamia-tamarind shells, and they produce better heating values.
33415632	1	69	theme	wastes	142:147	arg1	option					177:182	an attractive and viable option	152:182	an attractive and viable option to reduce the environmental pollution and reverse the over-exploitation of fossil fuels	152:270	The utilization of agricultural wastes is an attractive and viable option to reduce the environmental pollution and reverse the over-exploitation of fossil fuels.
33415632	1	69	theme	wastes	142:147	arg1	utilization					114:124	The utilization	110:124	The utilization of agricultural wastes	110:147	The utilization of agricultural wastes is an attractive and viable option to reduce the environmental pollution and reverse the over-exploitation of fossil fuels.
33415632	6	70	theme	heating	1298:1304	arg1	values					1306:1311	optimum heating values	1290:1311	optimum heating values	1290:1311	Weight loss and optimum heating values of the samples were measured by adopting differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) respectively.
33415632	3	71	theme	planned	714:720	arg1	200 kN					749:754	200 kN	749:754	200 kN	749:754	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	3	71	theme	planned	714:720	arg1	level					742:746	a planned compacting pressure level	712:746	a planned compacting pressure level (200 kN)	712:755	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	8	72	theme	panicle-pearl	1603:1615	arg1	briquettes					1624:1633	sorghum panicle-pearl millet briquettes	1595:1633	sorghum panicle-pearl millet briquettes	1595:1633	In comparison with pongamia-tamarind shell, sorghum panicle-pearl millet briquettes have better fuel properties.
33415632	14	73	theme	determined	2255:2264	arg1	parameters					2266:2275	the determined parameters	2251:2275	the determined parameters	2251:2275	Likewise, the determined parameters are compared with the other biomass briquettes.
33415632	9	74	contain	has	1697:1699	arg2	hydrogen					1714:1721	hydrogen	1714:1721	hydrogen	1714:1721	The pongamia-tamarind shell fuel has nitrogen and hydrogen whereas sorghum panicle-pearl millet has no identities on both nitrogen and hydrogen content.
33415632	9	74	contain	has	1697:1699	arg2	nitrogen					1701:1708	nitrogen	1701:1708	nitrogen	1701:1708	The pongamia-tamarind shell fuel has nitrogen and hydrogen whereas sorghum panicle-pearl millet has no identities on both nitrogen and hydrogen content.
33415632	9	74	contain	has	1697:1699	arg1	fuel					1692:1695	The pongamia-tamarind shell fuel	1664:1695	The pongamia-tamarind shell fuel	1664:1695	The pongamia-tamarind shell fuel has nitrogen and hydrogen whereas sorghum panicle-pearl millet has no identities on both nitrogen and hydrogen content.
33415632	2	75	from	pollution	446:454	arg1	source					393:398	limited source	385:398	limited source of fossil fuels and increase in environmental pollution with major consequences	385:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	0	76	theme	starch	95:100	arg1	binder					102:107	cassava starch binder	87:107	cassava starch binder	87:107	Combustion characteristics of briquette fuels from sorghum panicle-pearl millets using cassava starch binder.
33415632	8	77	theme	better	1640:1645	arg1	properties					1652:1661	better fuel properties	1640:1661	better fuel properties	1640:1661	In comparison with pongamia-tamarind shell, sorghum panicle-pearl millet briquettes have better fuel properties.
33415632	10	78	theme	NOx	1882:1884	arg1	emissions					1886:1894	NOx emissions	1882:1894	NOx emissions	1882:1894	The occurrence of nitrogen absence is due to non-availability of NOx emissions during combustion.
33415632	3	79	theme	compression	780:790	arg1	method					792:797	hydraulic compression method	770:797	hydraulic compression method	770:797	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	6	80	theme	scanning	1367:1374	arg1	DSC					1389:1391	DSC	1389:1391	DSC	1389:1391	Weight loss and optimum heating values of the samples were measured by adopting differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) respectively.
33415632	6	80	theme	scanning	1367:1374	arg1	calorimetry					1376:1386	differential scanning calorimetry	1354:1386	differential scanning calorimetry (DSC)	1354:1392	Weight loss and optimum heating values of the samples were measured by adopting differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) respectively.
33415632	9	81	theme	pongamia-tamarind	1668:1684	arg1	fuel					1692:1695	The pongamia-tamarind shell fuel	1664:1695	The pongamia-tamarind shell fuel	1664:1695	The pongamia-tamarind shell fuel has nitrogen and hydrogen whereas sorghum panicle-pearl millet has no identities on both nitrogen and hydrogen content.
33415632	3	82	theme	pressure	733:740	arg1	200 kN					749:754	200 kN	749:754	200 kN	749:754	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	3	82	theme	pressure	733:740	arg1	level					742:746	a planned compacting pressure level	712:746	a planned compacting pressure level (200 kN)	712:755	In this study, briquettes were produced using sorghum panicles (SP) and pearl millet (PM) with different ratios (100:0, 10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, 90:10 and 0:100) using cassava starch as a binder with a planned compacting pressure level (200 kN) by exploring hydraulic compression method.
33415632	5	83	theme	elemental	992:1000	arg1	analyses					1002:1009	The elemental analyses	988:1009	The elemental analyses (SEM/EDAX) which include carbon (C), oxygen (O), potassium (K), calcium (Ca), chlorine (Cl), sulphur (S), phosphorus (P), aluminium (Al), silicon (Si), magnesium (Mg), cobalt (Co), iron (Fe), zinc (Zn) and sodium (K)	988:1226	The elemental analyses (SEM/EDAX) which include carbon (C), oxygen (O), potassium (K), calcium (Ca), chlorine (Cl), sulphur (S), phosphorus (P), aluminium (Al), silicon (Si), magnesium (Mg), cobalt (Co), iron (Fe), zinc (Zn) and sodium (K) were determined in all the briquette samples.
33415632	5	83	theme	elemental	992:1000	arg1	SEM/EDAX					1012:1019	SEM/EDAX	1012:1019	SEM/EDAX	1012:1019	The elemental analyses (SEM/EDAX) which include carbon (C), oxygen (O), potassium (K), calcium (Ca), chlorine (Cl), sulphur (S), phosphorus (P), aluminium (Al), silicon (Si), magnesium (Mg), cobalt (Co), iron (Fe), zinc (Zn) and sodium (K) were determined in all the briquette samples.
33415632	8	84	contain	have	1635:1638	arg2	properties					1652:1661	better fuel properties	1640:1661	better fuel properties	1640:1661	In comparison with pongamia-tamarind shell, sorghum panicle-pearl millet briquettes have better fuel properties.
33415632	8	84	contain	have	1635:1638	arg1	briquettes					1624:1633	sorghum panicle-pearl millet briquettes	1595:1633	sorghum panicle-pearl millet briquettes	1595:1633	In comparison with pongamia-tamarind shell, sorghum panicle-pearl millet briquettes have better fuel properties.
33415632	4	85	theme	fixed	857:861	arg1	carbon					863:868	fixed carbon	857:868	fixed carbon	857:868	The proximate parameters such as water content, level of fixed carbon, ash and volatile matter were determined using American Society for Testing and Materials (ASTM) standard procedures.
33415632	2	86	theme	limited	385:391	arg1	source					393:398	limited source	385:398	limited source of fossil fuels and increase in environmental pollution with major consequences	385:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	0	87	theme	briquette	30:38	arg1	fuels					40:44	briquette fuels	30:44	briquette fuels	30:44	Combustion characteristics of briquette fuels from sorghum panicle-pearl millets using cassava starch binder.
33415632	7	88	theme	briquettes	1523:1532	arg1	density					1470:1476	density	1470:1476	density	1470:1476	In addition to that, the density and compressive strength of all the produced briquettes were determined.
33415632	7	88	theme	briquettes	1523:1532	arg1	strength					1494:1501	compressive strength	1482:1501	compressive strength	1482:1501	In addition to that, the density and compressive strength of all the produced briquettes were determined.
33415632	2	89	theme	environmental	432:444	arg1	pollution					446:454	environmental pollution	432:454	environmental pollution with major consequences	432:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	12	90	theme	heating	2128:2134	arg1	values					2136:2141	better heating values	2121:2141	better heating values	2121:2141	The sorghum panicle-pearl millet briquettes have better calorific value than pongamia-tamarind shells, and they produce better heating values.
33415632	2	91	theme	increase	420:427	arg1	source					393:398	limited source	385:398	limited source of fossil fuels and increase in environmental pollution with major consequences	385:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	14	92	dep	briquettes	2313:2322	arg1	are					2277:2279	are	2277:2279	are compared with the other biomass briquettes	2277:2322	Likewise, the determined parameters are compared with the other biomass briquettes.
33415632	9	93	theme	sorghum	1731:1737	arg1	millet					1753:1758	sorghum panicle-pearl millet	1731:1758	sorghum panicle-pearl millet	1731:1758	The pongamia-tamarind shell fuel has nitrogen and hydrogen whereas sorghum panicle-pearl millet has no identities on both nitrogen and hydrogen content.
33415632	2	94	theme	fuels	410:414	arg1	source					393:398	limited source	385:398	limited source of fossil fuels and increase in environmental pollution with major consequences	385:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	0	95	theme	panicle-pearl	59:71	arg1	millets					73:79	sorghum panicle-pearl millets	51:79	sorghum panicle-pearl millets using cassava starch binder	51:107	Combustion characteristics of briquette fuels from sorghum panicle-pearl millets using cassava starch binder.
33415632	2	96	contain	has	311:313	arg2	problems					355:362	increased manifold causing twin serious problems	315:362	increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences	315:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	2	96	contain	has	311:313	arg2	depletion					372:380	depletion	372:380	depletion of limited source of fossil fuels and increase in environmental pollution with major consequences	372:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	2	96	contain	has	311:313	arg1	Now-a-days					273:282	Now-a-days	273:282	Now-a-days	273:282	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	2	96	contain	has	311:313	arg1	usage					289:293	the usage	285:293	the usage of fossil fuels	285:309	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	6	97	theme	thermogravimetric	1398:1414	arg1	analysis					1416:1423	thermogravimetric analysis	1398:1423	thermogravimetric analysis (TGA)	1398:1429	Weight loss and optimum heating values of the samples were measured by adopting differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) respectively.
33415632	6	97	theme	thermogravimetric	1398:1414	arg1	TGA					1426:1428	TGA	1426:1428	TGA	1426:1428	Weight loss and optimum heating values of the samples were measured by adopting differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) respectively.
33415632	12	98	theme	sorghum	2005:2011	arg1	briquettes					2034:2043	The sorghum panicle-pearl millet briquettes	2001:2043	The sorghum panicle-pearl millet briquettes	2001:2043	The sorghum panicle-pearl millet briquettes have better calorific value than pongamia-tamarind shells, and they produce better heating values.
33415632	2	99	theme	serious	347:353	arg1	problems					355:362	increased manifold causing twin serious problems	315:362	increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences	315:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	2	99	theme	serious	347:353	arg1	depletion					372:380	depletion	372:380	depletion of limited source of fossil fuels and increase in environmental pollution with major consequences	372:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	7	100	theme	compressive	1482:1492	arg1	strength					1494:1501	compressive strength	1482:1501	compressive strength	1482:1501	In addition to that, the density and compressive strength of all the produced briquettes were determined.
33415632	11	101	theme	hydrogen	1983:1990	arg1	content					1992:1998	hydrogen content	1983:1998	hydrogen content	1983:1998	By the cause of more fixed carbon composition, there exists lack in hydrogen content.
33415632	12	102	theme	calorific	2057:2065	arg1	value					2067:2071	better calorific value	2050:2071	better calorific value	2050:2071	The sorghum panicle-pearl millet briquettes have better calorific value than pongamia-tamarind shells, and they produce better heating values.
33415632	2	103	theme	causing	334:340	arg1	problems					355:362	increased manifold causing twin serious problems	315:362	increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences	315:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	2	103	theme	causing	334:340	arg1	depletion					372:380	depletion	372:380	depletion of limited source of fossil fuels and increase in environmental pollution with major consequences	372:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	2	104	from	fuels	410:414	arg1	pollution					446:454	environmental pollution	432:454	environmental pollution with major consequences	432:478	Now-a-days, the usage of fossil fuels has increased manifold causing twin serious problems such as depletion of limited source of fossil fuels and increase in environmental pollution with major consequences.
33415632	1	105	theme	fossil	259:264	arg1	fuels					266:270	fossil fuels	259:270	fossil fuels	259:270	The utilization of agricultural wastes is an attractive and viable option to reduce the environmental pollution and reverse the over-exploitation of fossil fuels.
33579488	0	0	theme	polycaprolactone	98:113	arg1	kinetics					48:55	crystallization kinetics	32:55	crystallization kinetics	32:55	Cellulose nanocrystal effect on crystallization kinetics and biological properties of electrospun polycaprolactone.
33579488	0	0	theme	polycaprolactone	98:113	arg1	properties					72:81	biological properties	61:81	biological properties of electrospun polycaprolactone	61:113	Cellulose nanocrystal effect on crystallization kinetics and biological properties of electrospun polycaprolactone.
33579488	0	1	from	effect	22:27	arg1	kinetics					48:55	crystallization kinetics	32:55	crystallization kinetics	32:55	Cellulose nanocrystal effect on crystallization kinetics and biological properties of electrospun polycaprolactone.
33579488	0	1	from	effect	22:27	arg1	properties					72:81	biological properties	61:81	biological properties of electrospun polycaprolactone	61:113	Cellulose nanocrystal effect on crystallization kinetics and biological properties of electrospun polycaprolactone.
33579488	5	2	theme	CNC	807:809	arg1	incorporation					811:823	CNC incorporation	807:823	CNC incorporation up to 1%	807:832	Results showed that CNC incorporation up to 1% increases the crystallization activation energy and reduces the crystal volume, while these factors remain constant above this critical concentration.
33579488	10	3	theme	better	1546:1551	arg1	regeneration					1553:1564	better regeneration	1546:1564	better regeneration	1546:1564	H&E and Masson's trichrome staining showed better regeneration and more developed tissues in wounds treated with PCL-CNC1% nanofibers.
33579488	4	4	theme	PCL	730:732	arg1	structure					746:754	PCL crystalline structure	730:754	PCL crystalline structure	730:754	Ozawa-Flynn-Wall (OFW) methodology and X-ray diffraction were used to investigate the effect of CNC incorporation on PCL crystalline structure and its biological properties.
33579488	4	5	theme	Ozawa-Flynn-Wall	613:628	arg1	methodology					636:646	Ozawa-Flynn-Wall (OFW) methodology	613:646	Ozawa-Flynn-Wall (OFW) methodology	613:646	Ozawa-Flynn-Wall (OFW) methodology and X-ray diffraction were used to investigate the effect of CNC incorporation on PCL crystalline structure and its biological properties.
33579488	0	6	theme	electrospun	86:96	arg1	polycaprolactone					98:113	electrospun polycaprolactone	86:113	electrospun polycaprolactone	86:113	Cellulose nanocrystal effect on crystallization kinetics and biological properties of electrospun polycaprolactone.
33579488	7	7	theme	dynamic	1292:1298	arg1	studies					1321:1327	dynamic vapor sorption (DVS) studies	1292:1327	dynamic vapor sorption (DVS) studies	1292:1327	This behavior could be attributed to their greater hydrophilicity, which was confirmed using parallel exponential kinetics (PEK) model fitting to results obtained from dynamic vapor sorption (DVS) studies.
33579488	8	8	from	implantation	1407:1418	arg1	wounds					1438:1443	full-thickness wounds	1423:1443	full-thickness wounds	1423:1443	Superior performance of CNC containing samples was also confirmed by in vivo implantation on full-thickness wounds.
33579488	7	9	theme	greater	1167:1173	arg1	hydrophilicity					1175:1188	their greater hydrophilicity	1161:1188	their greater hydrophilicity	1161:1188	This behavior could be attributed to their greater hydrophilicity, which was confirmed using parallel exponential kinetics (PEK) model fitting to results obtained from dynamic vapor sorption (DVS) studies.
33579488	10	10	theme	%	1624:1624	arg1	nanofibers					1626:1635	PCL-CNC1% nanofibers	1616:1635	PCL-CNC1% nanofibers	1616:1635	H&E and Masson's trichrome staining showed better regeneration and more developed tissues in wounds treated with PCL-CNC1% nanofibers.
33579488	4	11	theme	OFW	631:633	arg1	methodology					636:646	Ozawa-Flynn-Wall (OFW) methodology	613:646	Ozawa-Flynn-Wall (OFW) methodology	613:646	Ozawa-Flynn-Wall (OFW) methodology and X-ray diffraction were used to investigate the effect of CNC incorporation on PCL crystalline structure and its biological properties.
33579488	10	12	theme	PCL-CNC1	1616:1623	arg1	nanofibers					1626:1635	PCL-CNC1% nanofibers	1616:1635	PCL-CNC1% nanofibers	1616:1635	H&E and Masson's trichrome staining showed better regeneration and more developed tissues in wounds treated with PCL-CNC1% nanofibers.
33579488	6	13	theme	cells	1028:1032	arg1	assay					989:993	MTT assay	985:993	MTT assay	985:993	MTT assay and microscopic images of seeded cells on the nanofiber scaffolds indicated increased cell growth on the samples containing CNC.
33579488	6	13	theme	cells	1028:1032	arg1	images					1011:1016	microscopic images	999:1016	microscopic images	999:1016	MTT assay and microscopic images of seeded cells on the nanofiber scaffolds indicated increased cell growth on the samples containing CNC.
33579488	1	14	theme	tissue	141:146	arg1	scaffolds					172:180	tissue engineering nanofibrous scaffolds	141:180	tissue engineering nanofibrous scaffolds	141:180	Mechanical properties of tissue engineering nanofibrous scaffolds are of importance because they not only determine their ease of application, but also influence the environment for cell growth and proliferation.
33579488	5	15	dep	1	831:831	arg1	to					828:829	to	828:829	to	828:829	Results showed that CNC incorporation up to 1% increases the crystallization activation energy and reduces the crystal volume, while these factors remain constant above this critical concentration.
33579488	8	16	theme	in	1399:1400	arg1	implantation					1407:1418	in vivo implantation	1399:1418	in vivo implantation on full-thickness wounds	1399:1443	Superior performance of CNC containing samples was also confirmed by in vivo implantation on full-thickness wounds.
33579488	4	17	from	effect	699:704	arg1	structure					746:754	PCL crystalline structure	730:754	PCL crystalline structure	730:754	Ozawa-Flynn-Wall (OFW) methodology and X-ray diffraction were used to investigate the effect of CNC incorporation on PCL crystalline structure and its biological properties.
33579488	4	17	from	effect	699:704	arg1	properties					775:784	its biological properties	760:784	its biological properties	760:784	Ozawa-Flynn-Wall (OFW) methodology and X-ray diffraction were used to investigate the effect of CNC incorporation on PCL crystalline structure and its biological properties.
33579488	5	18	theme	crystal	898:904	arg1	volume					906:911	the crystal volume	894:911	the crystal volume	894:911	Results showed that CNC incorporation up to 1% increases the crystallization activation energy and reduces the crystal volume, while these factors remain constant above this critical concentration.
33579488	5	19	dep	%	832:832	arg1	1					831:831	1	831:831	1	831:831	Results showed that CNC incorporation up to 1% increases the crystallization activation energy and reduces the crystal volume, while these factors remain constant above this critical concentration.
33579488	8	20	theme	Superior	1330:1337	arg1	performance					1339:1349	Superior performance	1330:1349	Superior performance of CNC containing samples	1330:1375	Superior performance of CNC containing samples was also confirmed by in vivo implantation on full-thickness wounds.
33579488	6	21	theme	increased	1071:1079	arg1	growth					1086:1091	increased cell growth	1071:1091	increased cell growth	1071:1091	MTT assay and microscopic images of seeded cells on the nanofiber scaffolds indicated increased cell growth on the samples containing CNC.
33579488	7	22	theme	exponential	1226:1236	arg1	PEK					1248:1250	PEK	1248:1250	PEK	1248:1250	This behavior could be attributed to their greater hydrophilicity, which was confirmed using parallel exponential kinetics (PEK) model fitting to results obtained from dynamic vapor sorption (DVS) studies.
33579488	7	22	theme	exponential	1226:1236	arg1	kinetics					1238:1245	parallel exponential kinetics	1217:1245	parallel exponential kinetics (PEK) model fitting to results obtained from dynamic vapor sorption (DVS) studies	1217:1327	This behavior could be attributed to their greater hydrophilicity, which was confirmed using parallel exponential kinetics (PEK) model fitting to results obtained from dynamic vapor sorption (DVS) studies.
33579488	6	23	theme	microscopic	999:1009	arg1	images					1011:1016	microscopic images	999:1016	microscopic images	999:1016	MTT assay and microscopic images of seeded cells on the nanofiber scaffolds indicated increased cell growth on the samples containing CNC.
33579488	7	24	theme	DVS	1316:1318	arg1	studies					1321:1327	dynamic vapor sorption (DVS) studies	1292:1327	dynamic vapor sorption (DVS) studies	1292:1327	This behavior could be attributed to their greater hydrophilicity, which was confirmed using parallel exponential kinetics (PEK) model fitting to results obtained from dynamic vapor sorption (DVS) studies.
33579488	7	25	theme	kinetics	1238:1245	arg1	model					1253:1257	parallel exponential kinetics (PEK) model	1217:1257	parallel exponential kinetics (PEK) model fitting to results obtained from dynamic vapor sorption (DVS) studies	1217:1327	This behavior could be attributed to their greater hydrophilicity, which was confirmed using parallel exponential kinetics (PEK) model fitting to results obtained from dynamic vapor sorption (DVS) studies.
33579488	6	26	theme	seeded	1021:1026	arg1	cells					1028:1032	seeded cells	1021:1032	seeded cells	1021:1032	MTT assay and microscopic images of seeded cells on the nanofiber scaffolds indicated increased cell growth on the samples containing CNC.
33579488	1	27	theme	Mechanical	116:125	arg1	properties					127:136	Mechanical properties	116:136	Mechanical properties of tissue engineering nanofibrous scaffolds	116:180	Mechanical properties of tissue engineering nanofibrous scaffolds are of importance because they not only determine their ease of application, but also influence the environment for cell growth and proliferation.
33579488	6	28	theme	nanofiber	1041:1049	arg1	scaffolds					1051:1059	the nanofiber scaffolds	1037:1059	the nanofiber scaffolds	1037:1059	MTT assay and microscopic images of seeded cells on the nanofiber scaffolds indicated increased cell growth on the samples containing CNC.
33579488	9	29	theme	wound	1450:1454	arg1	area					1456:1459	The wound area	1446:1459	The wound area	1446:1459	The wound area faded away more rapidly in these samples.
33579488	5	30	theme	crystallization	848:862	arg1	energy					875:880	the crystallization activation energy	844:880	the crystallization activation energy	844:880	Results showed that CNC incorporation up to 1% increases the crystallization activation energy and reduces the crystal volume, while these factors remain constant above this critical concentration.
33579488	6	31	from	images	1011:1016	arg1	scaffolds					1051:1059	the nanofiber scaffolds	1037:1059	the nanofiber scaffolds	1037:1059	MTT assay and microscopic images of seeded cells on the nanofiber scaffolds indicated increased cell growth on the samples containing CNC.
33579488	3	32	theme	composite	577:585	arg1	nanofibers					587:596	composite nanofibers	577:596	composite nanofibers	577:596	In this article, cellulose nanoparticles were incorporated into poly(caprolactone) (PCL) solution, and composite nanofibers were produced.
33579488	8	33	dep	in	1399:1400	arg1	vivo					1402:1405	vivo	1402:1405	vivo	1402:1405	Superior performance of CNC containing samples was also confirmed by in vivo implantation on full-thickness wounds.
33579488	4	34	theme	biological	764:773	arg1	properties					775:784	its biological properties	760:784	its biological properties	760:784	Ozawa-Flynn-Wall (OFW) methodology and X-ray diffraction were used to investigate the effect of CNC incorporation on PCL crystalline structure and its biological properties.
33579488	5	35	dep	incorporation	811:823	arg1	%					832:832	%	832:832	%	832:832	Results showed that CNC incorporation up to 1% increases the crystallization activation energy and reduces the crystal volume, while these factors remain constant above this critical concentration.
33579488	2	36	theme	Cellulose	329:337	arg1	nanocrystals					339:350	Cellulose nanocrystals	329:350	Cellulose nanocrystals (CNCs)	329:357	Cellulose nanocrystals (CNCs) are natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties.
33579488	2	36	theme	Cellulose	329:337	arg1	nanoparticles					381:393	natural renewable nanoparticles	363:393	natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties	363:471	Cellulose nanocrystals (CNCs) are natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties.
33579488	2	36	theme	Cellulose	329:337	arg1	CNCs					353:356	CNCs	353:356	CNCs	353:356	Cellulose nanocrystals (CNCs) are natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties.
33579488	2	37	theme	mechanical	451:460	arg1	properties					462:471	nanofibers' mechanical properties	439:471	nanofibers' mechanical properties	439:471	Cellulose nanocrystals (CNCs) are natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties.
33579488	10	38	theme	developed	1575:1583	arg1	tissues					1585:1591	more developed tissues	1570:1591	more developed tissues	1570:1591	H&E and Masson's trichrome staining showed better regeneration and more developed tissues in wounds treated with PCL-CNC1% nanofibers.
33579488	2	39	theme	natural	363:369	arg1	nanocrystals					339:350	Cellulose nanocrystals	329:350	Cellulose nanocrystals (CNCs)	329:357	Cellulose nanocrystals (CNCs) are natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties.
33579488	2	39	theme	natural	363:369	arg1	nanoparticles					381:393	natural renewable nanoparticles	363:393	natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties	363:471	Cellulose nanocrystals (CNCs) are natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties.
33579488	10	40	theme	trichrome	1520:1528	arg1	staining					1530:1537	H&E and Masson's trichrome staining	1503:1537	staining	1530:1537	H&E and Masson's trichrome staining showed better regeneration and more developed tissues in wounds treated with PCL-CNC1% nanofibers.
33579488	7	41	theme	vapor	1300:1304	arg1	studies					1321:1327	dynamic vapor sorption (DVS) studies	1292:1327	dynamic vapor sorption (DVS) studies	1292:1327	This behavior could be attributed to their greater hydrophilicity, which was confirmed using parallel exponential kinetics (PEK) model fitting to results obtained from dynamic vapor sorption (DVS) studies.
33579488	0	42	theme	crystallization	32:46	arg1	kinetics					48:55	crystallization kinetics	32:55	crystallization kinetics	32:55	Cellulose nanocrystal effect on crystallization kinetics and biological properties of electrospun polycaprolactone.
33579488	8	43	theme	CNC	1354:1356	arg1	samples					1369:1375	CNC containing samples	1354:1375	CNC containing samples	1354:1375	Superior performance of CNC containing samples was also confirmed by in vivo implantation on full-thickness wounds.
33579488	3	44	theme	cellulose	491:499	arg1	nanoparticles					501:513	cellulose nanoparticles	491:513	cellulose nanoparticles	491:513	In this article, cellulose nanoparticles were incorporated into poly(caprolactone) (PCL) solution, and composite nanofibers were produced.
33579488	0	45	theme	biological	61:70	arg1	properties					72:81	biological properties	61:81	biological properties of electrospun polycaprolactone	61:113	Cellulose nanocrystal effect on crystallization kinetics and biological properties of electrospun polycaprolactone.
33579488	2	46	theme	renewable	371:379	arg1	nanocrystals					339:350	Cellulose nanocrystals	329:350	Cellulose nanocrystals (CNCs)	329:357	Cellulose nanocrystals (CNCs) are natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties.
33579488	2	46	theme	renewable	371:379	arg1	nanoparticles					381:393	natural renewable nanoparticles	363:393	natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties	363:471	Cellulose nanocrystals (CNCs) are natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties.
33579488	3	47	theme	poly	538:541	arg1	solution					563:570	poly(caprolactone) (PCL) solution	538:570	poly(caprolactone) (PCL) solution	538:570	In this article, cellulose nanoparticles were incorporated into poly(caprolactone) (PCL) solution, and composite nanofibers were produced.
33579488	6	48	theme	MTT	985:987	arg1	assay					989:993	MTT assay	985:993	MTT assay	985:993	MTT assay and microscopic images of seeded cells on the nanofiber scaffolds indicated increased cell growth on the samples containing CNC.
33579488	8	49	theme	samples	1369:1375	arg1	performance					1339:1349	Superior performance	1330:1349	Superior performance of CNC containing samples	1330:1375	Superior performance of CNC containing samples was also confirmed by in vivo implantation on full-thickness wounds.
33579488	7	50	theme	parallel	1217:1224	arg1	PEK					1248:1250	PEK	1248:1250	PEK	1248:1250	This behavior could be attributed to their greater hydrophilicity, which was confirmed using parallel exponential kinetics (PEK) model fitting to results obtained from dynamic vapor sorption (DVS) studies.
33579488	7	50	theme	parallel	1217:1224	arg1	kinetics					1238:1245	parallel exponential kinetics	1217:1245	parallel exponential kinetics (PEK) model fitting to results obtained from dynamic vapor sorption (DVS) studies	1217:1327	This behavior could be attributed to their greater hydrophilicity, which was confirmed using parallel exponential kinetics (PEK) model fitting to results obtained from dynamic vapor sorption (DVS) studies.
33579488	1	51	theme	engineering	148:158	arg1	scaffolds					172:180	tissue engineering nanofibrous scaffolds	141:180	tissue engineering nanofibrous scaffolds	141:180	Mechanical properties of tissue engineering nanofibrous scaffolds are of importance because they not only determine their ease of application, but also influence the environment for cell growth and proliferation.
33579488	7	52	theme	sorption	1306:1313	arg1	studies					1321:1327	dynamic vapor sorption (DVS) studies	1292:1327	dynamic vapor sorption (DVS) studies	1292:1327	This behavior could be attributed to their greater hydrophilicity, which was confirmed using parallel exponential kinetics (PEK) model fitting to results obtained from dynamic vapor sorption (DVS) studies.
33579488	1	53	dep	cell	298:301	arg1	proliferation					314:326	proliferation	314:326	proliferation	314:326	Mechanical properties of tissue engineering nanofibrous scaffolds are of importance because they not only determine their ease of application, but also influence the environment for cell growth and proliferation.
33579488	1	53	dep	cell	298:301	arg1	growth					303:308	growth	303:308	growth	303:308	Mechanical properties of tissue engineering nanofibrous scaffolds are of importance because they not only determine their ease of application, but also influence the environment for cell growth and proliferation.
33579488	1	54	theme	nanofibrous	160:170	arg1	scaffolds					172:180	tissue engineering nanofibrous scaffolds	141:180	tissue engineering nanofibrous scaffolds	141:180	Mechanical properties of tissue engineering nanofibrous scaffolds are of importance because they not only determine their ease of application, but also influence the environment for cell growth and proliferation.
33579488	8	55	theme	full-thickness	1423:1436	arg1	wounds					1438:1443	full-thickness wounds	1423:1443	full-thickness wounds	1423:1443	Superior performance of CNC containing samples was also confirmed by in vivo implantation on full-thickness wounds.
33579488	6	56	theme	cell	1081:1084	arg1	growth					1086:1091	increased cell growth	1071:1091	increased cell growth	1071:1091	MTT assay and microscopic images of seeded cells on the nanofiber scaffolds indicated increased cell growth on the samples containing CNC.
33579488	6	57	from	assay	989:993	arg1	scaffolds					1051:1059	the nanofiber scaffolds	1037:1059	the nanofiber scaffolds	1037:1059	MTT assay and microscopic images of seeded cells on the nanofiber scaffolds indicated increased cell growth on the samples containing CNC.
33579488	8	58	theme	containing	1358:1367	arg1	samples					1369:1375	CNC containing samples	1354:1375	CNC containing samples	1354:1375	Superior performance of CNC containing samples was also confirmed by in vivo implantation on full-thickness wounds.
33579488	4	59	used	used	675:678	arg2	diffraction					658:668	X-ray diffraction	652:668	X-ray diffraction	652:668	Ozawa-Flynn-Wall (OFW) methodology and X-ray diffraction were used to investigate the effect of CNC incorporation on PCL crystalline structure and its biological properties.
33579488	4	59	used	used	675:678	arg2	methodology					636:646	Ozawa-Flynn-Wall (OFW) methodology	613:646	Ozawa-Flynn-Wall (OFW) methodology	613:646	Ozawa-Flynn-Wall (OFW) methodology and X-ray diffraction were used to investigate the effect of CNC incorporation on PCL crystalline structure and its biological properties.
33579488	1	60	theme	scaffolds	172:180	arg1	properties					127:136	Mechanical properties	116:136	Mechanical properties of tissue engineering nanofibrous scaffolds	116:180	Mechanical properties of tissue engineering nanofibrous scaffolds are of importance because they not only determine their ease of application, but also influence the environment for cell growth and proliferation.
33579488	5	61	theme	critical	961:968	arg1	concentration					970:982	this critical concentration	956:982	this critical concentration	956:982	Results showed that CNC incorporation up to 1% increases the crystallization activation energy and reduces the crystal volume, while these factors remain constant above this critical concentration.
33579488	1	62	theme	application	246:256	arg1	ease					238:241	their ease	232:241	their ease of application	232:256	Mechanical properties of tissue engineering nanofibrous scaffolds are of importance because they not only determine their ease of application, but also influence the environment for cell growth and proliferation.
33579488	2	63	used	used	417:420	arg2	nanocrystals					339:350	Cellulose nanocrystals	329:350	Cellulose nanocrystals (CNCs)	329:357	Cellulose nanocrystals (CNCs) are natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties.
33579488	2	63	used	used	417:420	arg2	nanoparticles					381:393	natural renewable nanoparticles	363:393	natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties	363:471	Cellulose nanocrystals (CNCs) are natural renewable nanoparticles that have been widely used for manipulating nanofibers' mechanical properties.
33579488	4	64	theme	incorporation	713:725	arg1	effect					699:704	the effect	695:704	the effect of CNC incorporation on PCL crystalline structure and its biological properties	695:784	Ozawa-Flynn-Wall (OFW) methodology and X-ray diffraction were used to investigate the effect of CNC incorporation on PCL crystalline structure and its biological properties.
33579488	4	65	theme	X-ray	652:656	arg1	diffraction					658:668	X-ray diffraction	652:668	X-ray diffraction	652:668	Ozawa-Flynn-Wall (OFW) methodology and X-ray diffraction were used to investigate the effect of CNC incorporation on PCL crystalline structure and its biological properties.
33579488	6	66	contain	containing	1108:1117	arg2	CNC					1119:1121	CNC	1119:1121	CNC	1119:1121	MTT assay and microscopic images of seeded cells on the nanofiber scaffolds indicated increased cell growth on the samples containing CNC.
33579488	6	66	contain	containing	1108:1117	arg1	samples					1100:1106	the samples	1096:1106	the samples containing CNC	1096:1121	MTT assay and microscopic images of seeded cells on the nanofiber scaffolds indicated increased cell growth on the samples containing CNC.
33579488	5	67	theme	activation	864:873	arg1	energy					875:880	the crystallization activation energy	844:880	the crystallization activation energy	844:880	Results showed that CNC incorporation up to 1% increases the crystallization activation energy and reduces the crystal volume, while these factors remain constant above this critical concentration.
33579488	4	68	theme	CNC	709:711	arg1	incorporation					713:725	CNC incorporation	709:725	CNC incorporation	709:725	Ozawa-Flynn-Wall (OFW) methodology and X-ray diffraction were used to investigate the effect of CNC incorporation on PCL crystalline structure and its biological properties.
33579488	4	69	theme	crystalline	734:744	arg1	structure					746:754	PCL crystalline structure	730:754	PCL crystalline structure	730:754	Ozawa-Flynn-Wall (OFW) methodology and X-ray diffraction were used to investigate the effect of CNC incorporation on PCL crystalline structure and its biological properties.
33220374	1	0	theme	drugs	262:266	arg1	drawback					163:170	A major drawback	155:170	A major drawback of oral treatment of inflammatory bowel disease (IBD)	155:224	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	1	0	theme	drugs	262:266	arg1	distribution					246:257	the non-specific distribution	229:257	the non-specific distribution of drugs during long-term treatment	229:293	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	1	1	theme	long-term	275:283	arg1	treatment					285:293	long-term treatment	275:293	long-term treatment	275:293	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	9	2	theme	effective	1648:1656	arg1	delivery					1658:1665	the effective delivery	1644:1665	the effective delivery of CUR in the treatment of colitis	1644:1700	The composite gel delivery system has potential for the effective delivery of CUR in the treatment of colitis.
33220374	4	3	theme	system	667:672	arg1	structure					640:648	structure	640:648	structure	640:648	The composition and structure of the composite system were optimized and the physicochemical properties were characterized using infrared spectroscopy, X-ray diffraction, swelling, and release behavior studies.
33220374	4	3	theme	system	667:672	arg1	composition					624:634	composition	624:634	composition	624:634	The composition and structure of the composite system were optimized and the physicochemical properties were characterized using infrared spectroscopy, X-ray diffraction, swelling, and release behavior studies.
33220374	10	4	with	system	1799:1804	arg1	behavior					1830:1837	controlled release behavior	1811:1837	controlled release behavior	1811:1837	This study also provides a reference for the design and preparation of a new oral drug delivery system with controlled release behavior.
33220374	1	5	theme	bowel	206:210	arg1	IBD					221:223	IBD	221:223	IBD	221:223	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	1	5	theme	bowel	206:210	arg1	disease					212:218	inflammatory bowel disease	193:218	inflammatory bowel disease (IBD)	193:224	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	0	6	theme	bowel	140:144	arg1	disease					146:152	inflammatory bowel disease	127:152	inflammatory bowel disease	127:152	Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease.
33220374	9	7	from	delivery	1658:1665	arg1	treatment					1681:1689	the treatment	1677:1689	the treatment of colitis	1677:1700	The composite gel delivery system has potential for the effective delivery of CUR in the treatment of colitis.
33220374	7	8	theme	necrosis	1381:1388	arg1	cytokines					1337:1345	the main pro-inflammatory cytokines	1311:1345	the main pro-inflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secreted by macrophages	1311:1429	Additionally, the formulation substantially inhibited the level of the main pro-inflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secreted by macrophages, compared to the control group.
33220374	3	9	theme	IBD	605:607	arg1	treatment					609:617	IBD treatment	605:617	IBD treatment	605:617	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33220374	5	10	theme	sustained	872:880	arg1	property					890:897	good sustained release property	867:897	good sustained release property	867:897	In vitro, the formulation exhibited good sustained release property and the drug release rate was 65% for 50 h.
33220374	9	11	theme	colitis	1694:1700	arg1	treatment					1681:1689	the treatment	1677:1689	the treatment of colitis	1677:1700	The composite gel delivery system has potential for the effective delivery of CUR in the treatment of colitis.
33220374	4	12	dep	composition	624:634	arg1	The					620:622	The	620:622	The	620:622	The composition and structure of the composite system were optimized and the physicochemical properties were characterized using infrared spectroscopy, X-ray diffraction, swelling, and release behavior studies.
33220374	4	13	theme	infrared	749:756	arg1	spectroscopy					758:769	infrared spectroscopy	749:769	infrared spectroscopy	749:769	The composition and structure of the composite system were optimized and the physicochemical properties were characterized using infrared spectroscopy, X-ray diffraction, swelling, and release behavior studies.
33220374	10	14	theme	delivery	1790:1797	arg1	system					1799:1804	a new oral drug delivery system	1774:1804	a new oral drug delivery system with controlled release behavior	1774:1837	This study also provides a reference for the design and preparation of a new oral drug delivery system with controlled release behavior.
33220374	8	15	theme	pharmacodynamic	1467:1481	arg1	experiment					1483:1492	The pharmacodynamic experiment	1463:1492	The pharmacodynamic experiment	1463:1492	The pharmacodynamic experiment showed that the formulation group of CUR@gels had the best therapeutic effect on colitis in mice.
33220374	7	16	theme	interleukin-6	1350:1362	arg1	cytokines					1337:1345	the main pro-inflammatory cytokines	1311:1345	the main pro-inflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secreted by macrophages	1311:1429	Additionally, the formulation substantially inhibited the level of the main pro-inflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secreted by macrophages, compared to the control group.
33220374	0	17	theme	controlled	81:90	arg1	delivery					97:104	controlled drug delivery	81:104	controlled drug delivery	81:104	Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease.
33220374	10	18	theme	oral	1780:1783	arg1	system					1799:1804	a new oral drug delivery system	1774:1804	a new oral drug delivery system with controlled release behavior	1774:1837	This study also provides a reference for the design and preparation of a new oral drug delivery system with controlled release behavior.
33220374	5	19	theme	release	912:918	arg1	rate					920:923	the drug release rate	903:923	the drug release rate	903:923	In vitro, the formulation exhibited good sustained release property and the drug release rate was 65% for 50 h.
33220374	5	19	theme	release	912:918	arg1	%					931:931	65%	929:931	65% for 50 h	929:940	In vitro, the formulation exhibited good sustained release property and the drug release rate was 65% for 50 h.
33220374	8	20	contain	had	1540:1542	arg2	effect					1565:1570	the best therapeutic effect	1544:1570	the best therapeutic effect on colitis in mice	1544:1589	The pharmacodynamic experiment showed that the formulation group of CUR@gels had the best therapeutic effect on colitis in mice.
33220374	8	20	contain	had	1540:1542	arg1	gels					1535:1538	CUR@gels	1531:1538	CUR@gels	1531:1538	The pharmacodynamic experiment showed that the formulation group of CUR@gels had the best therapeutic effect on colitis in mice.
33220374	8	20	contain	had	1540:1542	arg1	group					1522:1526	the formulation group	1506:1526	the formulation group of CUR@gels	1506:1538	The pharmacodynamic experiment showed that the formulation group of CUR@gels had the best therapeutic effect on colitis in mice.
33220374	1	21	theme	oral	175:178	arg1	treatment					180:188	oral treatment	175:188	oral treatment of inflammatory bowel disease (IBD)	175:224	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	6	22	theme	CUR	1008:1010	arg1	level					999:1003	high level	994:1003	high level of CUR	994:1010	In vivo pharmacokinetic experiments indicated that high level of CUR was maintained in the colon tissue for more than 24 h; it also played an anti-inflammatory role by evaluating the histopathological changes through hematoxylin and eosin (H&E), myeloperoxidase (MPO), and immunofluorescent staining.
33220374	3	23	contain	containing	518:527	arg1	system					511:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system	431:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR	431:584	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33220374	3	23	contain	containing	518:527	arg2	microspheres					557:568	carboxymethyl chitosan (CC) microspheres	529:568	carboxymethyl chitosan (CC) microspheres loaded with CUR	529:584	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33220374	8	24	theme	CUR	1531:1533	arg1	gels					1535:1538	CUR@gels	1531:1538	CUR@gels	1531:1538	The pharmacodynamic experiment showed that the formulation group of CUR@gels had the best therapeutic effect on colitis in mice.
33220374	0	25	theme	Carboxymethyl	0:12	arg1	microspheres					23:34	Carboxymethyl chitosan microspheres	0:34	Carboxymethyl chitosan microspheres	0:34	Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease.
33220374	7	26	theme	pro-inflammatory	1320:1335	arg1	cytokines					1337:1345	the main pro-inflammatory cytokines	1311:1345	the main pro-inflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secreted by macrophages	1311:1429	Additionally, the formulation substantially inhibited the level of the main pro-inflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secreted by macrophages, compared to the control group.
33220374	8	27	theme	gels	1535:1538	arg1	gels					1535:1538	CUR@gels	1531:1538	CUR@gels	1531:1538	The pharmacodynamic experiment showed that the formulation group of CUR@gels had the best therapeutic effect on colitis in mice.
33220374	8	27	theme	gels	1535:1538	arg1	group					1522:1526	the formulation group	1506:1526	the formulation group of CUR@gels	1506:1538	The pharmacodynamic experiment showed that the formulation group of CUR@gels had the best therapeutic effect on colitis in mice.
33220374	3	28	theme	acid/gelatin	467:478	arg1	system					511:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system	431:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR	431:584	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33220374	1	29	theme	major	157:161	arg1	drawback					163:170	A major drawback	155:170	A major drawback of oral treatment of inflammatory bowel disease (IBD)	155:224	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	1	29	theme	major	157:161	arg1	distribution					246:257	the non-specific distribution	229:257	the non-specific distribution of drugs during long-term treatment	229:293	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	2	30	theme	IBD	408:410	arg1	treatment					412:420	IBD treatment	408:420	IBD treatment	408:420	Despite its effectiveness as an anti-inflammatory drug, curcumin (CUR) is limited by its low bioavailability in IBD treatment.
33220374	3	31	theme	composite	446:454	arg1	system					511:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system	431:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR	431:584	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33220374	5	32	theme	release	882:888	arg1	property					890:897	good sustained release property	867:897	good sustained release property	867:897	In vitro, the formulation exhibited good sustained release property and the drug release rate was 65% for 50 h.
33220374	0	33	theme	hyaluronic	43:52	arg1	hydrogels					67:75	hyaluronic acid/gelatin hydrogels	43:75	hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease	43:152	Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease.
33220374	8	34	theme	therapeutic	1553:1563	arg1	effect					1565:1570	the best therapeutic effect	1544:1570	the best therapeutic effect on colitis in mice	1544:1589	The pharmacodynamic experiment showed that the formulation group of CUR@gels had the best therapeutic effect on colitis in mice.
33220374	3	35	theme	hydrogel	488:495	arg1	system					511:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system	431:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR	431:584	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33220374	2	36	from	bioavailability	389:403	arg1	treatment					412:420	IBD treatment	408:420	IBD treatment	408:420	Despite its effectiveness as an anti-inflammatory drug, curcumin (CUR) is limited by its low bioavailability in IBD treatment.
33220374	4	37	theme	behavior	813:820	arg1	studies					822:828	release behavior studies	805:828	release behavior studies	805:828	The composition and structure of the composite system were optimized and the physicochemical properties were characterized using infrared spectroscopy, X-ray diffraction, swelling, and release behavior studies.
33220374	3	38	theme	HA/GE	481:485	arg1	system					511:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system	431:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR	431:584	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33220374	9	39	theme	gel	1606:1608	arg1	system					1619:1624	The composite gel delivery system	1592:1624	The composite gel delivery system	1592:1624	The composite gel delivery system has potential for the effective delivery of CUR in the treatment of colitis.
33220374	1	40	theme	non-specific	233:244	arg1	drawback					163:170	A major drawback	155:170	A major drawback of oral treatment of inflammatory bowel disease (IBD)	155:224	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	1	40	theme	non-specific	233:244	arg1	distribution					246:257	the non-specific distribution	229:257	the non-specific distribution of drugs during long-term treatment	229:293	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	6	41	theme	anti-inflammatory	1085:1101	arg1	role					1103:1106	an anti-inflammatory role	1082:1106	an anti-inflammatory role	1082:1106	In vivo pharmacokinetic experiments indicated that high level of CUR was maintained in the colon tissue for more than 24 h; it also played an anti-inflammatory role by evaluating the histopathological changes through hematoxylin and eosin (H&E), myeloperoxidase (MPO), and immunofluorescent staining.
33220374	3	42	theme	delivery	502:509	arg1	system					511:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system	431:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR	431:584	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33220374	7	43	theme	control	1448:1454	arg1	group					1456:1460	the control group	1444:1460	the control group	1444:1460	Additionally, the formulation substantially inhibited the level of the main pro-inflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secreted by macrophages, compared to the control group.
33220374	3	44	theme	chitosan	543:550	arg1	microspheres					557:568	carboxymethyl chitosan (CC) microspheres	529:568	carboxymethyl chitosan (CC) microspheres loaded with CUR	529:584	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33220374	1	45	theme	treatment	180:188	arg1	drawback					163:170	A major drawback	155:170	A major drawback of oral treatment of inflammatory bowel disease (IBD)	155:224	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	1	45	theme	treatment	180:188	arg1	distribution					246:257	the non-specific distribution	229:257	the non-specific distribution of drugs during long-term treatment	229:293	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	4	46	theme	composite	657:665	arg1	system					667:672	the composite system	653:672	the composite system	653:672	The composition and structure of the composite system were optimized and the physicochemical properties were characterized using infrared spectroscopy, X-ray diffraction, swelling, and release behavior studies.
33220374	8	47	from	effect	1565:1570	arg1	mice					1586:1589	mice	1586:1589	mice	1586:1589	The pharmacodynamic experiment showed that the formulation group of CUR@gels had the best therapeutic effect on colitis in mice.
33220374	8	47	from	effect	1565:1570	arg1	colitis					1575:1581	colitis	1575:1581	colitis	1575:1581	The pharmacodynamic experiment showed that the formulation group of CUR@gels had the best therapeutic effect on colitis in mice.
33220374	2	48	theme	anti-inflammatory	328:344	arg1	drug					346:349	an anti-inflammatory drug	325:349	an anti-inflammatory drug	325:349	Despite its effectiveness as an anti-inflammatory drug, curcumin (CUR) is limited by its low bioavailability in IBD treatment.
33220374	1	49	theme	inflammatory	193:204	arg1	IBD					221:223	IBD	221:223	IBD	221:223	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	1	49	theme	inflammatory	193:204	arg1	disease					212:218	inflammatory bowel disease	193:218	inflammatory bowel disease (IBD)	193:224	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	6	50	theme	high	994:997	arg1	level					999:1003	high level	994:1003	high level of CUR	994:1010	In vivo pharmacokinetic experiments indicated that high level of CUR was maintained in the colon tissue for more than 24 h; it also played an anti-inflammatory role by evaluating the histopathological changes through hematoxylin and eosin (H&E), myeloperoxidase (MPO), and immunofluorescent staining.
33220374	9	51	theme	CUR	1670:1672	arg1	delivery					1658:1665	the effective delivery	1644:1665	the effective delivery of CUR in the treatment of colitis	1644:1700	The composite gel delivery system has potential for the effective delivery of CUR in the treatment of colitis.
33220374	0	52	theme	disease	146:152	arg1	delivery					97:104	controlled drug delivery	81:104	controlled drug delivery	81:104	Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease.
33220374	0	52	theme	disease	146:152	arg1	treatment					114:122	the treatment	110:122	the treatment of inflammatory bowel disease	110:152	Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease.
33220374	1	53	theme	disease	212:218	arg1	treatment					180:188	oral treatment	175:188	oral treatment of inflammatory bowel disease (IBD)	175:224	A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment.
33220374	6	54	dep	In	943:944	arg1	vivo					946:949	vivo	946:949	vivo	946:949	In vivo pharmacokinetic experiments indicated that high level of CUR was maintained in the colon tissue for more than 24 h; it also played an anti-inflammatory role by evaluating the histopathological changes through hematoxylin and eosin (H&E), myeloperoxidase (MPO), and immunofluorescent staining.
33220374	10	55	theme	new	1776:1778	arg1	system					1799:1804	a new oral drug delivery system	1774:1804	a new oral drug delivery system with controlled release behavior	1774:1837	This study also provides a reference for the design and preparation of a new oral drug delivery system with controlled release behavior.
33220374	5	56	theme	good	867:870	arg1	property					890:897	good sustained release property	867:897	good sustained release property	867:897	In vitro, the formulation exhibited good sustained release property and the drug release rate was 65% for 50 h.
33220374	6	57	theme	pharmacokinetic	951:965	arg1	experiments					967:977	In vivo pharmacokinetic experiments	943:977	In vivo pharmacokinetic experiments	943:977	In vivo pharmacokinetic experiments indicated that high level of CUR was maintained in the colon tissue for more than 24 h; it also played an anti-inflammatory role by evaluating the histopathological changes through hematoxylin and eosin (H&E), myeloperoxidase (MPO), and immunofluorescent staining.
33220374	6	58	theme	In	943:944	arg1	experiments					967:977	In vivo pharmacokinetic experiments	943:977	In vivo pharmacokinetic experiments	943:977	In vivo pharmacokinetic experiments indicated that high level of CUR was maintained in the colon tissue for more than 24 h; it also played an anti-inflammatory role by evaluating the histopathological changes through hematoxylin and eosin (H&E), myeloperoxidase (MPO), and immunofluorescent staining.
33220374	10	59	theme	release	1822:1828	arg1	behavior					1830:1837	controlled release behavior	1811:1837	controlled release behavior	1811:1837	This study also provides a reference for the design and preparation of a new oral drug delivery system with controlled release behavior.
33220374	7	60	theme	tumor	1375:1379	arg1	necrosis					1381:1388	tumor necrosis factor-α	1375:1397	tumor necrosis factor-α (TNF-α)	1375:1405	Additionally, the formulation substantially inhibited the level of the main pro-inflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secreted by macrophages, compared to the control group.
33220374	7	60	theme	tumor	1375:1379	arg1	TNF-α					1400:1404	TNF-α	1400:1404	TNF-α	1400:1404	Additionally, the formulation substantially inhibited the level of the main pro-inflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secreted by macrophages, compared to the control group.
33220374	10	61	theme	system	1799:1804	arg1	preparation					1759:1769	preparation	1759:1769	preparation	1759:1769	This study also provides a reference for the design and preparation of a new oral drug delivery system with controlled release behavior.
33220374	10	61	theme	system	1799:1804	arg1	design					1748:1753	design	1748:1753	design	1748:1753	This study also provides a reference for the design and preparation of a new oral drug delivery system with controlled release behavior.
33220374	6	62	theme	colon	1034:1038	arg1	tissue					1040:1045	the colon tissue	1030:1045	the colon tissue	1030:1045	In vivo pharmacokinetic experiments indicated that high level of CUR was maintained in the colon tissue for more than 24 h; it also played an anti-inflammatory role by evaluating the histopathological changes through hematoxylin and eosin (H&E), myeloperoxidase (MPO), and immunofluorescent staining.
33220374	10	63	dep	design	1748:1753	arg1	the					1744:1746	the	1744:1746	the	1744:1746	This study also provides a reference for the design and preparation of a new oral drug delivery system with controlled release behavior.
33220374	0	64	theme	drug	92:95	arg1	delivery					97:104	controlled drug delivery	81:104	controlled drug delivery	81:104	Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease.
33220374	10	65	theme	drug	1785:1788	arg1	system					1799:1804	a new oral drug delivery system	1774:1804	a new oral drug delivery system with controlled release behavior	1774:1837	This study also provides a reference for the design and preparation of a new oral drug delivery system with controlled release behavior.
33220374	5	66	theme	drug	907:910	arg1	rate					920:923	the drug release rate	903:923	the drug release rate	903:923	In vitro, the formulation exhibited good sustained release property and the drug release rate was 65% for 50 h.
33220374	5	66	theme	drug	907:910	arg1	%					931:931	65%	929:931	65% for 50 h	929:940	In vitro, the formulation exhibited good sustained release property and the drug release rate was 65% for 50 h.
33220374	8	67	theme	formulation	1510:1520	arg1	gels					1535:1538	CUR@gels	1531:1538	CUR@gels	1531:1538	The pharmacodynamic experiment showed that the formulation group of CUR@gels had the best therapeutic effect on colitis in mice.
33220374	8	67	theme	formulation	1510:1520	arg1	group					1522:1526	the formulation group	1506:1526	the formulation group of CUR@gels	1506:1538	The pharmacodynamic experiment showed that the formulation group of CUR@gels had the best therapeutic effect on colitis in mice.
33220374	4	68	theme	physicochemical	697:711	arg1	properties					713:722	the physicochemical properties	693:722	the physicochemical properties	693:722	The composition and structure of the composite system were optimized and the physicochemical properties were characterized using infrared spectroscopy, X-ray diffraction, swelling, and release behavior studies.
33220374	0	69	theme	inflammatory	127:138	arg1	disease					146:152	inflammatory bowel disease	127:152	inflammatory bowel disease	127:152	Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease.
33220374	7	70	theme	cytokines	1337:1345	arg1	level					1302:1306	the level	1298:1306	the level of the main pro-inflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secreted by macrophages	1298:1429	Additionally, the formulation substantially inhibited the level of the main pro-inflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secreted by macrophages, compared to the control group.
33220374	8	71	theme	@	1534:1534	arg1	gels					1535:1538	CUR@gels	1531:1538	CUR@gels	1531:1538	The pharmacodynamic experiment showed that the formulation group of CUR@gels had the best therapeutic effect on colitis in mice.
33220374	2	72	theme	low	385:387	arg1	bioavailability					389:403	its low bioavailability	381:403	its low bioavailability in IBD treatment	381:420	Despite its effectiveness as an anti-inflammatory drug, curcumin (CUR) is limited by its low bioavailability in IBD treatment.
33220374	0	73	theme	chitosan	14:21	arg1	microspheres					23:34	Carboxymethyl chitosan microspheres	0:34	Carboxymethyl chitosan microspheres	0:34	Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease.
33220374	7	74	theme	main	1315:1318	arg1	cytokines					1337:1345	the main pro-inflammatory cytokines	1311:1345	the main pro-inflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secreted by macrophages	1311:1429	Additionally, the formulation substantially inhibited the level of the main pro-inflammatory cytokines of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) secreted by macrophages, compared to the control group.
33220374	9	75	contain	has	1626:1628	arg2	potential					1630:1638	potential	1630:1638	potential for the effective delivery of CUR in the treatment of colitis	1630:1700	The composite gel delivery system has potential for the effective delivery of CUR in the treatment of colitis.
33220374	9	75	contain	has	1626:1628	arg1	system					1619:1624	The composite gel delivery system	1592:1624	The composite gel delivery system	1592:1624	The composite gel delivery system has potential for the effective delivery of CUR in the treatment of colitis.
33220374	6	76	theme	immunofluorescent	1216:1232	arg1	staining					1234:1241	immunofluorescent staining	1216:1241	immunofluorescent staining	1216:1241	In vivo pharmacokinetic experiments indicated that high level of CUR was maintained in the colon tissue for more than 24 h; it also played an anti-inflammatory role by evaluating the histopathological changes through hematoxylin and eosin (H&E), myeloperoxidase (MPO), and immunofluorescent staining.
33220374	4	77	theme	X-ray	772:776	arg1	diffraction					778:788	X-ray diffraction	772:788	X-ray diffraction	772:788	The composition and structure of the composite system were optimized and the physicochemical properties were characterized using infrared spectroscopy, X-ray diffraction, swelling, and release behavior studies.
33220374	0	78	theme	acid/gelatin	54:65	arg1	hydrogels					67:75	hyaluronic acid/gelatin hydrogels	43:75	hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease	43:152	Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease.
33220374	10	79	theme	controlled	1811:1820	arg1	behavior					1830:1837	controlled release behavior	1811:1837	controlled release behavior	1811:1837	This study also provides a reference for the design and preparation of a new oral drug delivery system with controlled release behavior.
33220374	3	80	theme	hyaluronic	456:465	arg1	system					511:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system	431:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR	431:584	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33220374	6	81	theme	histopathological	1126:1142	arg1	changes					1144:1150	the histopathological changes	1122:1150	the histopathological changes	1122:1150	In vivo pharmacokinetic experiments indicated that high level of CUR was maintained in the colon tissue for more than 24 h; it also played an anti-inflammatory role by evaluating the histopathological changes through hematoxylin and eosin (H&E), myeloperoxidase (MPO), and immunofluorescent staining.
33220374	3	82	theme	drug	497:500	arg1	system					511:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system	431:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR	431:584	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33220374	9	83	theme	composite	1596:1604	arg1	system					1619:1624	The composite gel delivery system	1592:1624	The composite gel delivery system	1592:1624	The composite gel delivery system has potential for the effective delivery of CUR in the treatment of colitis.
33220374	4	84	theme	release	805:811	arg1	studies					822:828	release behavior studies	805:828	release behavior studies	805:828	The composition and structure of the composite system were optimized and the physicochemical properties were characterized using infrared spectroscopy, X-ray diffraction, swelling, and release behavior studies.
33220374	9	85	theme	delivery	1610:1617	arg1	system					1619:1624	The composite gel delivery system	1592:1624	The composite gel delivery system	1592:1624	The composite gel delivery system has potential for the effective delivery of CUR in the treatment of colitis.
33220374	3	86	theme	pH-sensitive	433:444	arg1	system					511:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system	431:516	a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR	431:584	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33220374	3	87	theme	carboxymethyl	529:541	arg1	CC					553:554	CC	553:554	CC	553:554	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33220374	3	87	theme	carboxymethyl	529:541	arg1	chitosan					543:550	carboxymethyl chitosan	529:550	carboxymethyl chitosan (CC) microspheres loaded with CUR	529:584	Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment.
33999754	0	0	theme	soil	92:95	arg1	studies					105:111	soil release studies	92:111	soil release studies	92:111	Silica-coated calcium pectinate formulations for controlling carbendazim release: water and soil release studies.
33999754	9	1	theme	sustained	1379:1387	arg1	systems					1423:1429	sustained and economical pesticide delivery systems	1379:1429	sustained and economical pesticide delivery systems	1379:1429	Finally, the biodegradability of the pectin, and the release profile make such systems promising candidates for sustained and economical pesticide delivery systems.
33999754	4	2	dep	morphology	479:488	arg1	The					475:477	The	475:477	The	475:477	The morphology, composition and structure of both beads were characterized and the controlled release assays of the fungicide were studied in both water and soil columns.
33999754	2	3	theme	ionotropic	273:282	arg1	gelation					284:291	ionotropic gelation	273:291	ionotropic gelation	273:291	First, we have obtained calcium pectinate beads (CPG-Carb) by ionotropic gelation using calcium ions as a crosslinking agent.
33999754	0	4	theme	release	97:103	arg1	studies					105:111	soil release studies	92:111	soil release studies	92:111	Silica-coated calcium pectinate formulations for controlling carbendazim release: water and soil release studies.
33999754	7	5	theme	CPG-Carb-SG	1026:1036	arg1	release					1015:1021	the release	1011:1021	the release of CPG-Carb-SG	1011:1036	Moreover, the release of CPG-Carb-SG is due to the erosion of the silica layer during the first two weeks.
33999754	7	5	theme	CPG-Carb-SG	1026:1036	arg1	due					1041:1043	due	1041:1043	due	1041:1043	Moreover, the release of CPG-Carb-SG is due to the erosion of the silica layer during the first two weeks.
33999754	9	6	theme	pesticide	1404:1412	arg1	systems					1423:1429	sustained and economical pesticide delivery systems	1379:1429	sustained and economical pesticide delivery systems	1379:1429	Finally, the biodegradability of the pectin, and the release profile make such systems promising candidates for sustained and economical pesticide delivery systems.
33999754	9	7	theme	promising	1354:1362	arg1	candidates					1364:1373	promising candidates	1354:1373	promising candidates for sustained and economical pesticide delivery systems	1354:1429	Finally, the biodegradability of the pectin, and the release profile make such systems promising candidates for sustained and economical pesticide delivery systems.
33999754	6	8	from	rate	828:831	arg1	water					836:840	water	836:840	water	836:840	The release rate in water and soil columns was about 4 times lower for CPG-Carb-SG than CPG-Carb demonstrating the efficiency of the silica coating to delay the release of carbendazim.
33999754	6	8	from	rate	828:831	arg1	columns					851:857	soil columns	846:857	soil columns	846:857	The release rate in water and soil columns was about 4 times lower for CPG-Carb-SG than CPG-Carb demonstrating the efficiency of the silica coating to delay the release of carbendazim.
33999754	6	9	theme	release	820:826	arg1	rate					828:831	The release rate	816:831	The release rate in water and soil columns	816:857	The release rate in water and soil columns was about 4 times lower for CPG-Carb-SG than CPG-Carb demonstrating the efficiency of the silica coating to delay the release of carbendazim.
33999754	6	9	theme	release	820:826	arg1	times					871:875	times	871:875	times	871:875	The release rate in water and soil columns was about 4 times lower for CPG-Carb-SG than CPG-Carb demonstrating the efficiency of the silica coating to delay the release of carbendazim.
33999754	7	10	theme	silica	1067:1072	arg1	layer					1074:1078	the silica layer	1063:1078	the silica layer	1063:1078	Moreover, the release of CPG-Carb-SG is due to the erosion of the silica layer during the first two weeks.
33999754	8	11	theme	part	1224:1227	arg1	swelling					1200:1207	the swelling	1196:1207	the swelling of the organic part of the bead as observed for CPG-Carb	1196:1264	After this period, the silica layer was degraded, and the release is then controlled by the swelling of the organic part of the bead as observed for CPG-Carb.
33999754	9	12	theme	pectin	1304:1309	arg1	profile					1328:1334	the release profile	1316:1334	the release profile	1316:1334	Finally, the biodegradability of the pectin, and the release profile make such systems promising candidates for sustained and economical pesticide delivery systems.
33999754	9	12	theme	pectin	1304:1309	arg1	biodegradability					1280:1295	the biodegradability	1276:1295	the biodegradability of the pectin	1276:1309	Finally, the biodegradability of the pectin, and the release profile make such systems promising candidates for sustained and economical pesticide delivery systems.
33999754	7	13	theme	first	1091:1095	arg1	weeks					1101:1105	the first two weeks	1087:1105	the first two weeks	1087:1105	Moreover, the release of CPG-Carb-SG is due to the erosion of the silica layer during the first two weeks.
33999754	8	14	theme	organic	1216:1222	arg1	part					1224:1227	the organic part	1212:1227	the organic part of the bead as observed for CPG-Carb	1212:1264	After this period, the silica layer was degraded, and the release is then controlled by the swelling of the organic part of the bead as observed for CPG-Carb.
33999754	1	15	theme	biodegradable	179:191	arg1	polymer					193:199	a biodegradable polymer	177:199	a biodegradable polymer (pectin)	177:208	This study aims to encapsulate the fungicide carbendazim using a biodegradable polymer (pectin).
33999754	1	15	theme	biodegradable	179:191	arg1	pectin					202:207	pectin	202:207	pectin	202:207	This study aims to encapsulate the fungicide carbendazim using a biodegradable polymer (pectin).
33999754	0	16	theme	calcium	14:20	arg1	formulations					32:43	Silica-coated calcium pectinate formulations	0:43	Silica-coated calcium pectinate formulations for controlling carbendazim release	0:79	Silica-coated calcium pectinate formulations for controlling carbendazim release: water and soil release studies.
33999754	7	17	theme	layer	1074:1078	arg1	erosion					1052:1058	the erosion	1048:1058	the erosion of the silica layer during the first two weeks	1048:1105	Moreover, the release of CPG-Carb-SG is due to the erosion of the silica layer during the first two weeks.
33999754	5	18	theme	condensation	796:807	arg1	steps					809:813	condensation steps	796:813	condensation steps	796:813	The encapsulation efficiency for CPG-Carb was slightly higher (75%) compared to CPG-Carb-SG (67%) due to carbendazim loss during the impregnation and condensation steps.
33999754	0	19	theme	Silica-coated	0:12	arg1	formulations					32:43	Silica-coated calcium pectinate formulations	0:43	Silica-coated calcium pectinate formulations for controlling carbendazim release	0:79	Silica-coated calcium pectinate formulations for controlling carbendazim release: water and soil release studies.
33999754	2	20	theme	calcium	299:305	arg1	agent					330:334	a crosslinking agent	315:334	a crosslinking agent	315:334	First, we have obtained calcium pectinate beads (CPG-Carb) by ionotropic gelation using calcium ions as a crosslinking agent.
33999754	2	20	theme	calcium	299:305	arg1	ions					307:310	calcium ions	299:310	calcium ions	299:310	First, we have obtained calcium pectinate beads (CPG-Carb) by ionotropic gelation using calcium ions as a crosslinking agent.
33999754	8	21	theme	silica	1131:1136	arg1	layer					1138:1142	the silica layer	1127:1142	the silica layer	1127:1142	After this period, the silica layer was degraded, and the release is then controlled by the swelling of the organic part of the bead as observed for CPG-Carb.
33999754	5	22	theme	due	744:746	arg1	CPG-Carb-SG					726:736	CPG-Carb-SG	726:736	CPG-Carb-SG (67%) due to carbendazim loss during the impregnation and condensation steps	726:813	The encapsulation efficiency for CPG-Carb was slightly higher (75%) compared to CPG-Carb-SG (67%) due to carbendazim loss during the impregnation and condensation steps.
33999754	5	22	theme	due	744:746	arg1	%					741:741	67%	739:741	67%	739:741	The encapsulation efficiency for CPG-Carb was slightly higher (75%) compared to CPG-Carb-SG (67%) due to carbendazim loss during the impregnation and condensation steps.
33999754	5	23	theme	encapsulation	650:662	arg1	higher					701:706	higher	701:706	higher	701:706	The encapsulation efficiency for CPG-Carb was slightly higher (75%) compared to CPG-Carb-SG (67%) due to carbendazim loss during the impregnation and condensation steps.
33999754	5	23	theme	encapsulation	650:662	arg1	efficiency					664:673	The encapsulation efficiency	646:673	The encapsulation efficiency for CPG-Carb	646:686	The encapsulation efficiency for CPG-Carb was slightly higher (75%) compared to CPG-Carb-SG (67%) due to carbendazim loss during the impregnation and condensation steps.
33999754	0	24	dep	water	82:86	arg1	formulations					32:43	Silica-coated calcium pectinate formulations	0:43	Silica-coated calcium pectinate formulations for controlling carbendazim release	0:79	Silica-coated calcium pectinate formulations for controlling carbendazim release: water and soil release studies.
33999754	4	25	theme	fungicide	591:599	arg1	assays					577:582	the controlled release assays	554:582	the controlled release assays of the fungicide	554:599	The morphology, composition and structure of both beads were characterized and the controlled release assays of the fungicide were studied in both water and soil columns.
33999754	0	26	theme	pectinate	22:30	arg1	formulations					32:43	Silica-coated calcium pectinate formulations	0:43	Silica-coated calcium pectinate formulations for controlling carbendazim release	0:79	Silica-coated calcium pectinate formulations for controlling carbendazim release: water and soil release studies.
33999754	4	27	theme	beads	525:529	arg1	composition					491:501	composition	491:501	composition	491:501	The morphology, composition and structure of both beads were characterized and the controlled release assays of the fungicide were studied in both water and soil columns.
33999754	4	27	theme	beads	525:529	arg1	morphology					479:488	morphology	479:488	morphology	479:488	The morphology, composition and structure of both beads were characterized and the controlled release assays of the fungicide were studied in both water and soil columns.
33999754	4	27	theme	beads	525:529	arg1	structure					507:515	structure	507:515	structure	507:515	The morphology, composition and structure of both beads were characterized and the controlled release assays of the fungicide were studied in both water and soil columns.
33999754	9	28	theme	delivery	1414:1421	arg1	systems					1423:1429	sustained and economical pesticide delivery systems	1379:1429	sustained and economical pesticide delivery systems	1379:1429	Finally, the biodegradability of the pectin, and the release profile make such systems promising candidates for sustained and economical pesticide delivery systems.
33999754	8	29	theme	bead	1236:1239	arg1	part					1224:1227	the organic part	1212:1227	the organic part of the bead as observed for CPG-Carb	1212:1264	After this period, the silica layer was degraded, and the release is then controlled by the swelling of the organic part of the bead as observed for CPG-Carb.
33999754	9	30	theme	such	1341:1344	arg1	systems					1346:1352	such systems	1341:1352	such systems	1341:1352	Finally, the biodegradability of the pectin, and the release profile make such systems promising candidates for sustained and economical pesticide delivery systems.
33999754	9	31	theme	release	1320:1326	arg1	profile					1328:1334	the release profile	1316:1334	the release profile	1316:1334	Finally, the biodegradability of the pectin, and the release profile make such systems promising candidates for sustained and economical pesticide delivery systems.
33999754	6	32	theme	silica	949:954	arg1	coating					956:962	the silica coating	945:962	the silica coating	945:962	The release rate in water and soil columns was about 4 times lower for CPG-Carb-SG than CPG-Carb demonstrating the efficiency of the silica coating to delay the release of carbendazim.
33999754	6	33	theme	4	869:869	arg1	rate					828:831	The release rate	816:831	The release rate in water and soil columns	816:857	The release rate in water and soil columns was about 4 times lower for CPG-Carb-SG than CPG-Carb demonstrating the efficiency of the silica coating to delay the release of carbendazim.
33999754	6	33	theme	4	869:869	arg1	times					871:875	times	871:875	times	871:875	The release rate in water and soil columns was about 4 times lower for CPG-Carb-SG than CPG-Carb demonstrating the efficiency of the silica coating to delay the release of carbendazim.
33999754	3	34	theme	sol-gel	423:429	arg1	process					431:437	a sol-gel process	421:437	a sol-gel process to form hybrid beads (CPG-Carb-SG)	421:472	These beads were then coated with silica starting from tetraethoxysilane (TEOS), by a sol-gel process to form hybrid beads (CPG-Carb-SG).
33999754	5	35	dep	higher	701:706	arg1	%					711:711	75%	709:711	75%	709:711	The encapsulation efficiency for CPG-Carb was slightly higher (75%) compared to CPG-Carb-SG (67%) due to carbendazim loss during the impregnation and condensation steps.
33999754	5	35	dep	higher	701:706	arg1	compared					714:721	compared	714:721	compared to CPG-Carb-SG (67%) due to carbendazim loss during the impregnation and condensation steps	714:813	The encapsulation efficiency for CPG-Carb was slightly higher (75%) compared to CPG-Carb-SG (67%) due to carbendazim loss during the impregnation and condensation steps.
33999754	5	36	dep	impregnation	779:790	arg1	the					775:777	the	775:777	the	775:777	The encapsulation efficiency for CPG-Carb was slightly higher (75%) compared to CPG-Carb-SG (67%) due to carbendazim loss during the impregnation and condensation steps.
33999754	0	37	theme	carbendazim	61:71	arg1	release					73:79	carbendazim release	61:79	carbendazim release	61:79	Silica-coated calcium pectinate formulations for controlling carbendazim release: water and soil release studies.
33999754	1	38	theme	fungicide	149:157	arg1	carbendazim					159:169	the fungicide carbendazim	145:169	the fungicide carbendazim using a biodegradable polymer (pectin)	145:208	This study aims to encapsulate the fungicide carbendazim using a biodegradable polymer (pectin).
33999754	2	39	theme	crosslinking	317:328	arg1	agent					330:334	a crosslinking agent	315:334	a crosslinking agent	315:334	First, we have obtained calcium pectinate beads (CPG-Carb) by ionotropic gelation using calcium ions as a crosslinking agent.
33999754	2	39	theme	crosslinking	317:328	arg1	ions					307:310	calcium ions	299:310	calcium ions	299:310	First, we have obtained calcium pectinate beads (CPG-Carb) by ionotropic gelation using calcium ions as a crosslinking agent.
33999754	6	40	dep	times	871:875	arg1	lower					877:881	lower	877:881	lower	877:881	The release rate in water and soil columns was about 4 times lower for CPG-Carb-SG than CPG-Carb demonstrating the efficiency of the silica coating to delay the release of carbendazim.
33999754	4	41	theme	release	569:575	arg1	assays					577:582	the controlled release assays	554:582	the controlled release assays of the fungicide	554:599	The morphology, composition and structure of both beads were characterized and the controlled release assays of the fungicide were studied in both water and soil columns.
33999754	9	42	theme	economical	1393:1402	arg1	systems					1423:1429	sustained and economical pesticide delivery systems	1379:1429	sustained and economical pesticide delivery systems	1379:1429	Finally, the biodegradability of the pectin, and the release profile make such systems promising candidates for sustained and economical pesticide delivery systems.
33999754	3	43	theme	hybrid	447:452	arg1	beads					454:458	hybrid beads	447:458	hybrid beads (CPG-Carb-SG)	447:472	These beads were then coated with silica starting from tetraethoxysilane (TEOS), by a sol-gel process to form hybrid beads (CPG-Carb-SG).
33999754	3	43	theme	hybrid	447:452	arg1	CPG-Carb-SG					461:471	CPG-Carb-SG	461:471	CPG-Carb-SG	461:471	These beads were then coated with silica starting from tetraethoxysilane (TEOS), by a sol-gel process to form hybrid beads (CPG-Carb-SG).
33999754	4	44	theme	controlled	558:567	arg1	assays					577:582	the controlled release assays	554:582	the controlled release assays of the fungicide	554:599	The morphology, composition and structure of both beads were characterized and the controlled release assays of the fungicide were studied in both water and soil columns.
33999754	6	45	theme	coating	956:962	arg1	efficiency					931:940	the efficiency	927:940	the efficiency of the silica coating to delay the release of carbendazim	927:998	The release rate in water and soil columns was about 4 times lower for CPG-Carb-SG than CPG-Carb demonstrating the efficiency of the silica coating to delay the release of carbendazim.
33999754	2	46	theme	pectinate	243:251	arg1	CPG-Carb					260:267	CPG-Carb	260:267	CPG-Carb	260:267	First, we have obtained calcium pectinate beads (CPG-Carb) by ionotropic gelation using calcium ions as a crosslinking agent.
33999754	2	46	theme	pectinate	243:251	arg1	beads					253:257	calcium pectinate beads	235:257	calcium pectinate beads (CPG-Carb)	235:268	First, we have obtained calcium pectinate beads (CPG-Carb) by ionotropic gelation using calcium ions as a crosslinking agent.
33999754	5	47	theme	carbendazim	751:761	arg1	loss					763:766	carbendazim loss	751:766	carbendazim loss during the impregnation and condensation steps	751:813	The encapsulation efficiency for CPG-Carb was slightly higher (75%) compared to CPG-Carb-SG (67%) due to carbendazim loss during the impregnation and condensation steps.
33999754	6	48	theme	carbendazim	988:998	arg1	release					977:983	the release	973:983	the release of carbendazim	973:998	The release rate in water and soil columns was about 4 times lower for CPG-Carb-SG than CPG-Carb demonstrating the efficiency of the silica coating to delay the release of carbendazim.
33999754	6	49	theme	soil	846:849	arg1	columns					851:857	soil columns	846:857	soil columns	846:857	The release rate in water and soil columns was about 4 times lower for CPG-Carb-SG than CPG-Carb demonstrating the efficiency of the silica coating to delay the release of carbendazim.
33999754	2	50	theme	calcium	235:241	arg1	CPG-Carb					260:267	CPG-Carb	260:267	CPG-Carb	260:267	First, we have obtained calcium pectinate beads (CPG-Carb) by ionotropic gelation using calcium ions as a crosslinking agent.
33999754	2	50	theme	calcium	235:241	arg1	beads					253:257	calcium pectinate beads	235:257	calcium pectinate beads (CPG-Carb)	235:268	First, we have obtained calcium pectinate beads (CPG-Carb) by ionotropic gelation using calcium ions as a crosslinking agent.
33999754	4	51	theme	soil	632:635	arg1	columns					637:643	soil columns	632:643	soil columns	632:643	The morphology, composition and structure of both beads were characterized and the controlled release assays of the fungicide were studied in both water and soil columns.
34507185	3	0	theme	15:1	748:751	arg1	ratio					739:743	a catalyst/cellulose mass ratio	713:743	a catalyst/cellulose mass ratio of 15:1	713:751	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	6	1	theme	hydrocarbons	1328:1339	arg1	production					1290:1299	the production	1286:1299	the production of aromatics and aliphatic hydrocarbons	1286:1339	From another aspect, the composite metal oxides with better porous structures contributed to deoxygenation conversion for the production of aromatics and aliphatic hydrocarbons.
34507185	3	2	theme	mass	734:737	arg1	ratio					739:743	a catalyst/cellulose mass ratio	713:743	a catalyst/cellulose mass ratio of 15:1	713:751	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	3	3	theme	acidity-to-basicity	499:517	arg1	ratios					519:524	Higher acidity-to-basicity ratios	492:524	Higher acidity-to-basicity ratios	492:524	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	3	4	with	750 °C	701:706	arg1	ratio					739:743	a catalyst/cellulose mass ratio	713:743	a catalyst/cellulose mass ratio of 15:1	713:751	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	1	5	theme	site	211:214	arg1	role					186:189	the role	182:189	the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS	182:307	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	0	6	theme	pyrolysis	56:64	arg1	kinetics					66:73	fast pyrolysis kinetics	51:73	fast pyrolysis kinetics	51:73	Insight into the role of varied acid-base sites on fast pyrolysis kinetics and mechanism of cellulose.
34507185	4	7	theme	%	882:882	arg1	ketones					884:890	70% ketones	880:890	70% ketones	880:890	In comparison, lowering acidity-to-basicity ratios mainly facilitated the ketonization and aldol condensation, therefore over 70% ketones was attained in the case of CaO catalysis.
34507185	8	8	theme	good	1461:1464	arg1	reference					1466:1474	a good reference	1459:1474	a good reference	1459:1474	This work would provide a good reference for the realization of product regulation from cellulose pyrolysis via adjusting acid-base sites in metal oxides.
34507185	8	9	theme	product	1499:1505	arg1	regulation					1507:1516	product regulation	1499:1516	product regulation	1499:1516	This work would provide a good reference for the realization of product regulation from cellulose pyrolysis via adjusting acid-base sites in metal oxides.
34507185	8	10	from	sites	1567:1571	arg1	oxides					1582:1587	metal oxides	1576:1587	metal oxides	1576:1587	This work would provide a good reference for the realization of product regulation from cellulose pyrolysis via adjusting acid-base sites in metal oxides.
34507185	6	11	theme	porous	1224:1229	arg1	structures					1231:1240	better porous structures	1217:1240	better porous structures	1217:1240	From another aspect, the composite metal oxides with better porous structures contributed to deoxygenation conversion for the production of aromatics and aliphatic hydrocarbons.
34507185	6	12	with	oxides	1205:1210	arg1	structures					1231:1240	better porous structures	1217:1240	better porous structures	1217:1240	From another aspect, the composite metal oxides with better porous structures contributed to deoxygenation conversion for the production of aromatics and aliphatic hydrocarbons.
34507185	3	13	theme	deoxygenation	556:568	arg1	process					570:576	deoxygenation process	556:576	deoxygenation process	556:576	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	5	14	from	role	988:991	arg1	pyrolysis					1025:1033	cellulose pyrolysis	1015:1033	cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol	1015:1088	The kinetic studies further verified the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol, in comparison with that of cellulose pyrolysis without adding catalysts.
34507185	5	15	theme	promotional	976:986	arg1	role					988:991	the promotional role	972:991	the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol	972:1088	The kinetic studies further verified the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol, in comparison with that of cellulose pyrolysis without adding catalysts.
34507185	8	16	from	pyrolysis	1533:1541	arg1	realization					1484:1494	the realization	1480:1494	the realization of product regulation from cellulose pyrolysis	1480:1541	This work would provide a good reference for the realization of product regulation from cellulose pyrolysis via adjusting acid-base sites in metal oxides.
34507185	6	17	theme	aromatics	1304:1312	arg1	production					1290:1299	the production	1286:1299	the production of aromatics and aliphatic hydrocarbons	1286:1339	From another aspect, the composite metal oxides with better porous structures contributed to deoxygenation conversion for the production of aromatics and aliphatic hydrocarbons.
34507185	3	18	theme	process	570:576	arg1	proceeding					542:551	the proceeding	538:551	the proceeding of deoxygenation process	538:576	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	5	19	theme	kinetic	939:945	arg1	studies					947:953	The kinetic studies	935:953	The kinetic studies	935:953	The kinetic studies further verified the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol, in comparison with that of cellulose pyrolysis without adding catalysts.
34507185	0	20	theme	cellulose	92:100	arg1	mechanism					79:87	mechanism	79:87	mechanism of cellulose	79:100	Insight into the role of varied acid-base sites on fast pyrolysis kinetics and mechanism of cellulose.
34507185	0	20	theme	cellulose	92:100	arg1	kinetics					66:73	fast pyrolysis kinetics	51:73	fast pyrolysis kinetics	51:73	Insight into the role of varied acid-base sites on fast pyrolysis kinetics and mechanism of cellulose.
34507185	8	21	theme	metal	1576:1580	arg1	oxides					1582:1587	metal oxides	1576:1587	metal oxides	1576:1587	This work would provide a good reference for the realization of product regulation from cellulose pyrolysis via adjusting acid-base sites in metal oxides.
34507185	8	22	theme	cellulose	1523:1531	arg1	pyrolysis					1533:1541	cellulose pyrolysis	1523:1541	cellulose pyrolysis	1523:1541	This work would provide a good reference for the realization of product regulation from cellulose pyrolysis via adjusting acid-base sites in metal oxides.
34507185	6	23	theme	composite	1189:1197	arg1	oxides					1205:1210	the composite metal oxides	1185:1210	the composite metal oxides with better porous structures	1185:1240	From another aspect, the composite metal oxides with better porous structures contributed to deoxygenation conversion for the production of aromatics and aliphatic hydrocarbons.
34507185	7	24	theme	reaction	1362:1369	arg1	pathway					1371:1377	plausible reaction pathway	1352:1377	plausible reaction pathway for cellulose pyrolysis over metal oxides	1352:1419	Moreover, plausible reaction pathway for cellulose pyrolysis over metal oxides was proposed.
34507185	2	25	theme	acidity-to-basicity	352:370	arg1	value					372:376	acidity-to-basicity value	352:376	acidity-to-basicity value	352:376	The results showed that the modulation of acidity-to-basicity value via altering metal oxides constituents significantly affected the transformation pathway for cellulose pyrolysis.
34507185	3	26	theme	catalyst/cellulose	715:732	arg1	ratio					739:743	a catalyst/cellulose mass ratio	713:743	a catalyst/cellulose mass ratio of 15:1	713:751	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	4	27	theme	acidity-to-basicity	778:796	arg1	ratios					798:803	lowering acidity-to-basicity ratios	769:803	lowering acidity-to-basicity ratios mainly facilitated the ketonization and aldol condensation, therefore over 70% ketones	769:890	In comparison, lowering acidity-to-basicity ratios mainly facilitated the ketonization and aldol condensation, therefore over 70% ketones was attained in the case of CaO catalysis.
34507185	1	28	theme	metal	140:144	arg1	oxides					146:151	metal oxides	140:151	metal oxides	140:151	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	2	29	theme	cellulose	471:479	arg1	pyrolysis					481:489	cellulose pyrolysis	471:489	cellulose pyrolysis	471:489	The results showed that the modulation of acidity-to-basicity value via altering metal oxides constituents significantly affected the transformation pathway for cellulose pyrolysis.
34507185	1	30	from	mechanism	232:240	arg1	role					186:189	the role	182:189	the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS	182:307	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	1	31	theme	oxides	146:151	arg1	series					130:135	a series	128:135	a series of metal oxides	128:151	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	6	32	theme	better	1217:1222	arg1	structures					1231:1240	better porous structures	1217:1240	better porous structures	1217:1240	From another aspect, the composite metal oxides with better porous structures contributed to deoxygenation conversion for the production of aromatics and aliphatic hydrocarbons.
34507185	4	33	theme	70	880:881	arg1	%					882:882	%	882:882	%	882:882	In comparison, lowering acidity-to-basicity ratios mainly facilitated the ketonization and aldol condensation, therefore over 70% ketones was attained in the case of CaO catalysis.
34507185	3	34	theme	%	591:591	arg1	aromatics					593:601	wherein 39.4% aromatics and 34.7%	579:611	aromatics	593:601	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	5	35	with	comparison	1094:1103	arg1	that					1110:1113	that	1110:1113	that	1110:1113	The kinetic studies further verified the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol, in comparison with that of cellulose pyrolysis without adding catalysts.
34507185	6	36	theme	aliphatic	1318:1326	arg1	hydrocarbons					1328:1339	aliphatic hydrocarbons	1318:1339	aliphatic hydrocarbons	1318:1339	From another aspect, the composite metal oxides with better porous structures contributed to deoxygenation conversion for the production of aromatics and aliphatic hydrocarbons.
34507185	8	37	theme	regulation	1507:1516	arg1	realization					1484:1494	the realization	1480:1494	the realization of product regulation from cellulose pyrolysis	1480:1541	This work would provide a good reference for the realization of product regulation from cellulose pyrolysis via adjusting acid-base sites in metal oxides.
34507185	5	38	theme	cellulose	1015:1023	arg1	pyrolysis					1025:1033	cellulose pyrolysis	1015:1033	cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol	1015:1088	The kinetic studies further verified the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol, in comparison with that of cellulose pyrolysis without adding catalysts.
34507185	1	39	from	kinetics	219:226	arg1	role					186:189	the role	182:189	the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS	182:307	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	2	40	theme	metal	391:395	arg1	constituents					404:415	metal oxides constituents	391:415	metal oxides constituents	391:415	The results showed that the modulation of acidity-to-basicity value via altering metal oxides constituents significantly affected the transformation pathway for cellulose pyrolysis.
34507185	2	41	theme	oxides	397:402	arg1	constituents					404:415	metal oxides constituents	391:415	metal oxides constituents	391:415	The results showed that the modulation of acidity-to-basicity value via altering metal oxides constituents significantly affected the transformation pathway for cellulose pyrolysis.
34507185	1	42	theme	catalytic	246:254	arg1	pyrolysis					261:269	catalytic fast pyrolysis	246:269	catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS	246:307	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	4	43	theme	catalysis	924:932	arg1	case					912:915	the case	908:915	the case of CaO catalysis	908:932	In comparison, lowering acidity-to-basicity ratios mainly facilitated the ketonization and aldol condensation, therefore over 70% ketones was attained in the case of CaO catalysis.
34507185	3	44	theme	wherein	579:585	arg1	aromatics					593:601	wherein 39.4% aromatics and 34.7%	579:611	aromatics	593:601	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	7	45	theme	plausible	1352:1360	arg1	pathway					1371:1377	plausible reaction pathway	1352:1377	plausible reaction pathway for cellulose pyrolysis over metal oxides	1352:1419	Moreover, plausible reaction pathway for cellulose pyrolysis over metal oxides was proposed.
34507185	0	46	theme	varied	25:30	arg1	sites					42:46	varied acid-base sites	25:46	varied acid-base sites	25:46	Insight into the role of varied acid-base sites on fast pyrolysis kinetics and mechanism of cellulose.
34507185	1	47	theme	fast	256:259	arg1	pyrolysis					261:269	catalytic fast pyrolysis	246:269	catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS	246:307	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	1	48	from	site	211:214	arg1	mechanism					232:240	mechanism	232:240	mechanism	232:240	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	1	48	from	site	211:214	arg1	kinetics					219:226	kinetics	219:226	kinetics	219:226	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	3	49	theme	acidity-to-basicity	663:681	arg1	value					683:687	acidity-to-basicity value	663:687	acidity-to-basicity value of 1.38	663:695	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	4	50	theme	aldol	845:849	arg1	condensation					851:862	aldol condensation	845:862	aldol condensation	845:862	In comparison, lowering acidity-to-basicity ratios mainly facilitated the ketonization and aldol condensation, therefore over 70% ketones was attained in the case of CaO catalysis.
34507185	6	51	theme	metal	1199:1203	arg1	oxides					1205:1210	the composite metal oxides	1185:1210	the composite metal oxides with better porous structures	1185:1240	From another aspect, the composite metal oxides with better porous structures contributed to deoxygenation conversion for the production of aromatics and aliphatic hydrocarbons.
34507185	5	52	theme	apparent	1040:1047	arg1	energy					1060:1065	apparent activation energy	1040:1065	apparent activation energy as low as 33.72 kJ/mol	1040:1088	The kinetic studies further verified the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol, in comparison with that of cellulose pyrolysis without adding catalysts.
34507185	2	53	theme	value	372:376	arg1	modulation					338:347	the modulation	334:347	the modulation of acidity-to-basicity value via altering metal oxides constituents	334:415	The results showed that the modulation of acidity-to-basicity value via altering metal oxides constituents significantly affected the transformation pathway for cellulose pyrolysis.
34507185	0	54	theme	sites	42:46	arg1	role					17:20	the role	13:20	the role of varied acid-base sites on fast pyrolysis kinetics and mechanism of cellulose	13:100	Insight into the role of varied acid-base sites on fast pyrolysis kinetics and mechanism of cellulose.
34507185	7	55	theme	metal	1408:1412	arg1	oxides					1414:1419	metal oxides	1408:1419	metal oxides	1408:1419	Moreover, plausible reaction pathway for cellulose pyrolysis over metal oxides was proposed.
34507185	5	56	with	pyrolysis	1025:1033	arg1	energy					1060:1065	apparent activation energy	1040:1065	apparent activation energy as low as 33.72 kJ/mol	1040:1088	The kinetic studies further verified the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol, in comparison with that of cellulose pyrolysis without adding catalysts.
34507185	5	57	theme	activation	1049:1058	arg1	energy					1060:1065	apparent activation energy	1040:1065	apparent activation energy as low as 33.72 kJ/mol	1040:1088	The kinetic studies further verified the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol, in comparison with that of cellulose pyrolysis without adding catalysts.
34507185	4	58	theme	CaO	920:922	arg1	catalysis					924:932	CaO catalysis	920:932	CaO catalysis	920:932	In comparison, lowering acidity-to-basicity ratios mainly facilitated the ketonization and aldol condensation, therefore over 70% ketones was attained in the case of CaO catalysis.
34507185	0	59	theme	acid-base	32:40	arg1	sites					42:46	varied acid-base sites	25:46	varied acid-base sites	25:46	Insight into the role of varied acid-base sites on fast pyrolysis kinetics and mechanism of cellulose.
34507185	1	60	theme	cellulose	274:282	arg1	pyrolysis					261:269	catalytic fast pyrolysis	246:269	catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS	246:307	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	8	61	theme	acid-base	1557:1565	arg1	sites					1567:1571	acid-base sites	1557:1571	acid-base sites in metal oxides	1557:1587	This work would provide a good reference for the realization of product regulation from cellulose pyrolysis via adjusting acid-base sites in metal oxides.
34507185	3	62	theme	1.38	692:695	arg1	value					683:687	acidity-to-basicity value	663:687	acidity-to-basicity value of 1.38	663:695	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	3	63	theme	Higher	492:497	arg1	ratios					519:524	Higher acidity-to-basicity ratios	492:524	Higher acidity-to-basicity ratios	492:524	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	1	64	from	role	186:189	arg1	mechanism					232:240	mechanism	232:240	mechanism	232:240	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	1	64	from	role	186:189	arg1	kinetics					219:226	kinetics	219:226	kinetics	219:226	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	5	65	theme	low	1070:1072	arg1	energy					1060:1065	apparent activation energy	1040:1065	apparent activation energy as low as 33.72 kJ/mol	1040:1088	The kinetic studies further verified the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol, in comparison with that of cellulose pyrolysis without adding catalysts.
34507185	5	66	theme	sites	1006:1010	arg1	role					988:991	the promotional role	972:991	the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol	972:1088	The kinetic studies further verified the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol, in comparison with that of cellulose pyrolysis without adding catalysts.
34507185	6	67	theme	deoxygenation	1257:1269	arg1	conversion					1271:1280	deoxygenation conversion	1257:1280	deoxygenation conversion	1257:1280	From another aspect, the composite metal oxides with better porous structures contributed to deoxygenation conversion for the production of aromatics and aliphatic hydrocarbons.
34507185	5	68	theme	acid-base	996:1004	arg1	sites					1006:1010	acid-base sites	996:1010	acid-base sites	996:1010	The kinetic studies further verified the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol, in comparison with that of cellulose pyrolysis without adding catalysts.
34507185	4	69	theme	lowering	769:776	arg1	ratios					798:803	lowering acidity-to-basicity ratios	769:803	lowering acidity-to-basicity ratios mainly facilitated the ketonization and aldol condensation, therefore over 70% ketones	769:890	In comparison, lowering acidity-to-basicity ratios mainly facilitated the ketonization and aldol condensation, therefore over 70% ketones was attained in the case of CaO catalysis.
34507185	1	70	theme	present	110:116	arg1	research					118:125	the present research	106:125	the present research	106:125	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	3	71	dep	Al2O3	656:660	arg1	value					683:687	acidity-to-basicity value	663:687	acidity-to-basicity value of 1.38	663:695	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	0	72	theme	fast	51:54	arg1	kinetics					66:73	fast pyrolysis kinetics	51:73	fast pyrolysis kinetics	51:73	Insight into the role of varied acid-base sites on fast pyrolysis kinetics and mechanism of cellulose.
34507185	3	73	theme	aliphatic	613:621	arg1	hydrocarbons					623:634	wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons	579:634	wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons	579:634	Higher acidity-to-basicity ratios accelerated the proceeding of deoxygenation process, wherein 39.4% aromatics and 34.7% aliphatic hydrocarbons were achieved using Al2O3 (acidity-to-basicity value of 1.38) at 750 °C with a catalyst/cellulose mass ratio of 15:1.
34507185	7	74	theme	cellulose	1383:1391	arg1	pyrolysis					1393:1401	cellulose pyrolysis	1383:1401	cellulose pyrolysis over metal oxides	1383:1419	Moreover, plausible reaction pathway for cellulose pyrolysis over metal oxides was proposed.
34507185	1	75	theme	varied	194:199	arg1	site					211:214	varied acid-base site	194:214	varied acid-base site on kinetics and mechanism	194:240	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34507185	2	76	theme	transformation	444:457	arg1	pathway					459:465	the transformation pathway	440:465	the transformation pathway for cellulose pyrolysis	440:489	The results showed that the modulation of acidity-to-basicity value via altering metal oxides constituents significantly affected the transformation pathway for cellulose pyrolysis.
34507185	0	77	from	role	17:20	arg1	mechanism					79:87	mechanism	79:87	mechanism of cellulose	79:100	Insight into the role of varied acid-base sites on fast pyrolysis kinetics and mechanism of cellulose.
34507185	0	77	from	role	17:20	arg1	kinetics					66:73	fast pyrolysis kinetics	51:73	fast pyrolysis kinetics	51:73	Insight into the role of varied acid-base sites on fast pyrolysis kinetics and mechanism of cellulose.
34507185	5	78	theme	cellulose	1118:1126	arg1	pyrolysis					1128:1136	cellulose pyrolysis	1118:1136	cellulose pyrolysis without adding catalysts	1118:1161	The kinetic studies further verified the promotional role of acid-base sites on cellulose pyrolysis with apparent activation energy as low as 33.72 kJ/mol, in comparison with that of cellulose pyrolysis without adding catalysts.
34507185	1	79	theme	acid-base	201:209	arg1	site					211:214	varied acid-base site	194:214	varied acid-base site on kinetics and mechanism	194:240	In the present research, a series of metal oxides were employed to investigate the role of varied acid-base site on kinetics and mechanism for catalytic fast pyrolysis of cellulose using TG-MS and Py-GC/MS.
34096938	1	0	dep	in	326:327	arg1	vivo					329:332	vivo	329:332	vivo	329:332	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	4	1	theme	T2	869:870	arg1	MRI					882:884	T2*-weighted MRI	869:884	T2*-weighted MRI	869:884	Composite scaffolds containing up to 0.3 weight % USPIOs were 3D printed by MEW and could be sensitively detected in vitro using T2- and T2*-weighted MRI.
34096938	8	2	theme	grafts	1420:1425	arg1	monitoring					1402:1411	longitudinal monitoring	1389:1411	longitudinal monitoring of MEW grafts	1389:1425	This work contributes to the materials library for MEW and opens the possibility of using MRI for longitudinal monitoring of MEW grafts.
34096938	2	3	theme	constructs	383:392	arg1	translation					363:373	The clinical translation	350:373	The clinical translation of such constructs to the patient	350:407	The clinical translation of such constructs to the patient requires the capability to visualize them upon implantation with clinically accepted methods such as magnetic resonance imaging (MRI).
34096938	2	4	theme	resonance	519:527	arg1	MRI					538:540	MRI	538:540	MRI	538:540	The clinical translation of such constructs to the patient requires the capability to visualize them upon implantation with clinically accepted methods such as magnetic resonance imaging (MRI).
34096938	2	4	theme	resonance	519:527	arg1	imaging					529:535	magnetic resonance imaging	510:535	magnetic resonance imaging (MRI)	510:541	The clinical translation of such constructs to the patient requires the capability to visualize them upon implantation with clinically accepted methods such as magnetic resonance imaging (MRI).
34096938	1	5	dep	in	313:314	arg1	vitro					316:320	vitro	316:320	vitro	316:320	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	1	6	theme	digital	185:191	arg1	fabrication					193:203	the digital fabrication	181:203	the digital fabrication of complex micro-structured scaffolds for tissue engineering	181:264	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	5	7	theme	tissue	965:970	arg1	applications					984:995	tissue engineering applications	965:995	tissue engineering applications	965:995	At the same time, USPIO incorporation did not affect the usability of PCL for tissue engineering applications as demonstrated by the mechanical and cytocompatibility evaluation.
34096938	4	8	theme	-weighted	872:880	arg1	MRI					882:884	T2*-weighted MRI	869:884	T2*-weighted MRI	869:884	Composite scaffolds containing up to 0.3 weight % USPIOs were 3D printed by MEW and could be sensitively detected in vitro using T2- and T2*-weighted MRI.
34096938	8	9	theme	longitudinal	1389:1400	arg1	monitoring					1402:1411	longitudinal monitoring	1389:1411	longitudinal monitoring of MEW grafts	1389:1425	This work contributes to the materials library for MEW and opens the possibility of using MRI for longitudinal monitoring of MEW grafts.
34096938	4	10	theme	0.3	769:771	arg1	weight					773:778	weight	773:778	weight	773:778	Composite scaffolds containing up to 0.3 weight % USPIOs were 3D printed by MEW and could be sensitively detected in vitro using T2- and T2*-weighted MRI.
34096938	7	11	theme	adhering	1260:1267	arg1	cells					1254:1258	proliferating cells	1240:1258	proliferating cells adhering to all the scaffolds	1240:1288	Cytocompatibility tests resulted in excellent cell viability, with proliferating cells adhering to all the scaffolds.
34096938	4	12	theme	*	871:871	arg1	MRI					882:884	T2*-weighted MRI	869:884	T2*-weighted MRI	869:884	Composite scaffolds containing up to 0.3 weight % USPIOs were 3D printed by MEW and could be sensitively detected in vitro using T2- and T2*-weighted MRI.
34096938	4	13	dep	USPIOs	782:787	arg1	%					780:780	%	780:780	%	780:780	Composite scaffolds containing up to 0.3 weight % USPIOs were 3D printed by MEW and could be sensitively detected in vitro using T2- and T2*-weighted MRI.
34096938	5	14	theme	USPIO	905:909	arg1	incorporation					911:923	USPIO incorporation	905:923	USPIO incorporation	905:923	At the same time, USPIO incorporation did not affect the usability of PCL for tissue engineering applications as demonstrated by the mechanical and cytocompatibility evaluation.
34096938	4	15	contain	containing	752:761	arg2	USPIOs					782:787	up to 0.3 weight % USPIOs	763:787	up to 0.3 weight % USPIOs	763:787	Composite scaffolds containing up to 0.3 weight % USPIOs were 3D printed by MEW and could be sensitively detected in vitro using T2- and T2*-weighted MRI.
34096938	4	15	contain	containing	752:761	arg1	scaffolds					742:750	Composite scaffolds	732:750	Composite scaffolds containing up to 0.3 weight % USPIOs	732:787	Composite scaffolds containing up to 0.3 weight % USPIOs were 3D printed by MEW and could be sensitively detected in vitro using T2- and T2*-weighted MRI.
34096938	6	16	theme	Young	1156:1160	arg1	modulus					1164:1170	Young's modulus	1156:1170	Young's modulus	1156:1170	Concentrations up to 0.2% caused small to no decrease in the ultimate tensile strength and Young's modulus.
34096938	8	17	theme	materials	1320:1328	arg1	library					1330:1336	the materials library	1316:1336	the materials library for MEW	1316:1344	This work contributes to the materials library for MEW and opens the possibility of using MRI for longitudinal monitoring of MEW grafts.
34096938	7	18	theme	Cytocompatibility	1173:1189	arg1	tests					1191:1195	Cytocompatibility tests	1173:1195	Cytocompatibility tests	1173:1195	Cytocompatibility tests resulted in excellent cell viability, with proliferating cells adhering to all the scaffolds.
34096938	1	19	theme	Melt	105:108	arg1	MEW					126:128	MEW	126:128	MEW	126:128	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	1	19	theme	Melt	105:108	arg1	technology					166:175	a high-resolution fiber-forming technology	134:175	a high-resolution fiber-forming technology	134:175	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	1	19	theme	Melt	105:108	arg1	electrowriting					110:123	Melt electrowriting	105:123	Melt electrowriting (MEW)	105:129	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	2	20	theme	accepted	485:492	arg1	imaging					529:535	magnetic resonance imaging	510:535	magnetic resonance imaging (MRI)	510:541	The clinical translation of such constructs to the patient requires the capability to visualize them upon implantation with clinically accepted methods such as magnetic resonance imaging (MRI).
34096938	2	20	theme	accepted	485:492	arg1	methods					494:500	clinically accepted methods	474:500	clinically accepted methods such as magnetic resonance imaging (MRI)	474:541	The clinical translation of such constructs to the patient requires the capability to visualize them upon implantation with clinically accepted methods such as magnetic resonance imaging (MRI).
34096938	7	21	theme	excellent	1209:1217	arg1	viability					1224:1232	excellent cell viability	1209:1232	excellent cell viability	1209:1232	Cytocompatibility tests resulted in excellent cell viability, with proliferating cells adhering to all the scaffolds.
34096938	4	22	dep	weight	773:778	arg1	to					766:767	to	766:767	to	766:767	Composite scaffolds containing up to 0.3 weight % USPIOs were 3D printed by MEW and could be sensitively detected in vitro using T2- and T2*-weighted MRI.
34096938	7	23	theme	cell	1219:1222	arg1	viability					1224:1232	excellent cell viability	1209:1232	excellent cell viability	1209:1232	Cytocompatibility tests resulted in excellent cell viability, with proliferating cells adhering to all the scaffolds.
34096938	6	24	dep	Concentrations	1065:1078	arg1	%					1089:1089	%	1089:1089	%	1089:1089	Concentrations up to 0.2% caused small to no decrease in the ultimate tensile strength and Young's modulus.
34096938	1	25	theme	complex	208:214	arg1	scaffolds					233:241	complex micro-structured scaffolds	208:241	complex micro-structured scaffolds	208:241	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	1	26	theme	in	313:314	arg1	studies					341:347	in vitro and in vivo animal studies	313:347	in vitro and in vivo animal studies	313:347	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	6	27	theme	tensile	1135:1141	arg1	strength					1143:1150	the ultimate tensile strength	1122:1150	the ultimate tensile strength	1122:1150	Concentrations up to 0.2% caused small to no decrease in the ultimate tensile strength and Young's modulus.
34096938	1	28	theme	micro-structured	216:231	arg1	scaffolds					233:241	complex micro-structured scaffolds	208:241	complex micro-structured scaffolds	208:241	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	0	29	theme	melt-electrowritten	31:49	arg1	scaffolds					51:59	USPIO-labeled melt-electrowritten scaffolds	17:59	USPIO-labeled melt-electrowritten scaffolds	17:59	Visualization of USPIO-labeled melt-electrowritten scaffolds by non-invasive magnetic resonance imaging.
34096938	5	30	theme	engineering	972:982	arg1	applications					984:995	tissue engineering applications	965:995	tissue engineering applications	965:995	At the same time, USPIO incorporation did not affect the usability of PCL for tissue engineering applications as demonstrated by the mechanical and cytocompatibility evaluation.
34096938	1	31	from	potential	300:308	arg1	studies					341:347	in vitro and in vivo animal studies	313:347	in vitro and in vivo animal studies	313:347	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	5	32	theme	same	894:897	arg1	time					899:902	the same time	890:902	the same time	890:902	At the same time, USPIO incorporation did not affect the usability of PCL for tissue engineering applications as demonstrated by the mechanical and cytocompatibility evaluation.
34096938	6	33	theme	ultimate	1126:1133	arg1	strength					1143:1150	the ultimate tensile strength	1122:1150	the ultimate tensile strength	1122:1150	Concentrations up to 0.2% caused small to no decrease in the ultimate tensile strength and Young's modulus.
34096938	1	34	theme	scaffolds	233:241	arg1	fabrication					193:203	the digital fabrication	181:203	the digital fabrication of complex micro-structured scaffolds for tissue engineering	181:264	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	0	35	theme	USPIO-labeled	17:29	arg1	scaffolds					51:59	USPIO-labeled melt-electrowritten scaffolds	17:59	USPIO-labeled melt-electrowritten scaffolds	17:59	Visualization of USPIO-labeled melt-electrowritten scaffolds by non-invasive magnetic resonance imaging.
34096938	2	36	theme	such	378:381	arg1	constructs					383:392	such constructs	378:392	such constructs	378:392	The clinical translation of such constructs to the patient requires the capability to visualize them upon implantation with clinically accepted methods such as magnetic resonance imaging (MRI).
34096938	7	37	theme	proliferating	1240:1252	arg1	cells					1254:1258	proliferating cells	1240:1258	proliferating cells adhering to all the scaffolds	1240:1288	Cytocompatibility tests resulted in excellent cell viability, with proliferating cells adhering to all the scaffolds.
34096938	2	38	theme	magnetic	510:517	arg1	MRI					538:540	MRI	538:540	MRI	538:540	The clinical translation of such constructs to the patient requires the capability to visualize them upon implantation with clinically accepted methods such as magnetic resonance imaging (MRI).
34096938	2	38	theme	magnetic	510:517	arg1	imaging					529:535	magnetic resonance imaging	510:535	magnetic resonance imaging (MRI)	510:541	The clinical translation of such constructs to the patient requires the capability to visualize them upon implantation with clinically accepted methods such as magnetic resonance imaging (MRI).
34096938	1	39	theme	in	326:327	arg1	studies					341:347	in vitro and in vivo animal studies	313:347	in vitro and in vivo animal studies	313:347	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	6	40	dep	%	1089:1089	arg1	0.2					1086:1088	0.2	1086:1088	0.2	1086:1088	Concentrations up to 0.2% caused small to no decrease in the ultimate tensile strength and Young's modulus.
34096938	1	41	theme	tissue	247:252	arg1	engineering					254:264	tissue engineering	247:264	tissue engineering	247:264	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	0	42	theme	scaffolds	51:59	arg1	Visualization					0:12	Visualization	0:12	Visualization of USPIO-labeled melt-electrowritten scaffolds by non-invasive magnetic resonance imaging.	0:103	Visualization of USPIO-labeled melt-electrowritten scaffolds by non-invasive magnetic resonance imaging.
34096938	3	43	theme	iron	663:666	arg1	USPIO					675:679	USPIO	675:679	USPIO	675:679	To this end, this work presents the modification of polycaprolactone (PCL) scaffolds with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to render them visualizable by MRI.
34096938	3	43	theme	iron	663:666	arg1	oxide					668:672	ultrasmall superparamagnetic iron oxide	634:672	ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles	634:694	To this end, this work presents the modification of polycaprolactone (PCL) scaffolds with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to render them visualizable by MRI.
34096938	6	44	dep	0.2	1086:1088	arg1	to					1083:1084	to	1083:1084	to	1083:1084	Concentrations up to 0.2% caused small to no decrease in the ultimate tensile strength and Young's modulus.
34096938	0	45	theme	magnetic	77:84	arg1	imaging					96:102	non-invasive magnetic resonance imaging	64:102	non-invasive magnetic resonance imaging	64:102	Visualization of USPIO-labeled melt-electrowritten scaffolds by non-invasive magnetic resonance imaging.
34096938	1	46	theme	animal	334:339	arg1	studies					341:347	in vitro and in vivo animal studies	313:347	in vitro and in vivo animal studies	313:347	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	3	47	theme	oxide	668:672	arg1	nanoparticles					682:694	ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles	634:694	ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles	634:694	To this end, this work presents the modification of polycaprolactone (PCL) scaffolds with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to render them visualizable by MRI.
34096938	3	48	theme	polycaprolactone	596:611	arg1	scaffolds					619:627	polycaprolactone (PCL) scaffolds	596:627	polycaprolactone (PCL) scaffolds with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles	596:694	To this end, this work presents the modification of polycaprolactone (PCL) scaffolds with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to render them visualizable by MRI.
34096938	2	49	with	implantation	456:467	arg1	imaging					529:535	magnetic resonance imaging	510:535	magnetic resonance imaging (MRI)	510:541	The clinical translation of such constructs to the patient requires the capability to visualize them upon implantation with clinically accepted methods such as magnetic resonance imaging (MRI).
34096938	2	49	with	implantation	456:467	arg1	methods					494:500	clinically accepted methods	474:500	clinically accepted methods such as magnetic resonance imaging (MRI)	474:541	The clinical translation of such constructs to the patient requires the capability to visualize them upon implantation with clinically accepted methods such as magnetic resonance imaging (MRI).
34096938	4	50	theme	Composite	732:740	arg1	scaffolds					742:750	Composite scaffolds	732:750	Composite scaffolds containing up to 0.3 weight % USPIOs	732:787	Composite scaffolds containing up to 0.3 weight % USPIOs were 3D printed by MEW and could be sensitively detected in vitro using T2- and T2*-weighted MRI.
34096938	0	51	theme	non-invasive	64:75	arg1	imaging					96:102	non-invasive magnetic resonance imaging	64:102	non-invasive magnetic resonance imaging	64:102	Visualization of USPIO-labeled melt-electrowritten scaffolds by non-invasive magnetic resonance imaging.
34096938	5	52	theme	mechanical	1020:1029	arg1	evaluation					1053:1062	the mechanical and cytocompatibility evaluation	1016:1062	the mechanical and cytocompatibility evaluation	1016:1062	At the same time, USPIO incorporation did not affect the usability of PCL for tissue engineering applications as demonstrated by the mechanical and cytocompatibility evaluation.
34096938	4	53	dep	%	780:780	arg1	weight					773:778	weight	773:778	weight	773:778	Composite scaffolds containing up to 0.3 weight % USPIOs were 3D printed by MEW and could be sensitively detected in vitro using T2- and T2*-weighted MRI.
34096938	3	54	theme	ultrasmall	634:643	arg1	USPIO					675:679	USPIO	675:679	USPIO	675:679	To this end, this work presents the modification of polycaprolactone (PCL) scaffolds with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to render them visualizable by MRI.
34096938	3	54	theme	ultrasmall	634:643	arg1	oxide					668:672	ultrasmall superparamagnetic iron oxide	634:672	ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles	634:694	To this end, this work presents the modification of polycaprolactone (PCL) scaffolds with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to render them visualizable by MRI.
34096938	6	55	from	decrease	1110:1117	arg1	strength					1143:1150	the ultimate tensile strength	1122:1150	the ultimate tensile strength	1122:1150	Concentrations up to 0.2% caused small to no decrease in the ultimate tensile strength and Young's modulus.
34096938	1	56	theme	high-resolution	136:150	arg1	electrowriting					110:123	Melt electrowriting	105:123	Melt electrowriting (MEW)	105:129	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	1	56	theme	high-resolution	136:150	arg1	technology					166:175	a high-resolution fiber-forming technology	134:175	a high-resolution fiber-forming technology	134:175	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	5	57	theme	PCL	957:959	arg1	usability					944:952	the usability	940:952	the usability of PCL for tissue engineering applications	940:995	At the same time, USPIO incorporation did not affect the usability of PCL for tissue engineering applications as demonstrated by the mechanical and cytocompatibility evaluation.
34096938	5	58	theme	cytocompatibility	1035:1051	arg1	evaluation					1053:1062	the mechanical and cytocompatibility evaluation	1016:1062	the mechanical and cytocompatibility evaluation	1016:1062	At the same time, USPIO incorporation did not affect the usability of PCL for tissue engineering applications as demonstrated by the mechanical and cytocompatibility evaluation.
34096938	3	59	theme	superparamagnetic	645:661	arg1	USPIO					675:679	USPIO	675:679	USPIO	675:679	To this end, this work presents the modification of polycaprolactone (PCL) scaffolds with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to render them visualizable by MRI.
34096938	3	59	theme	superparamagnetic	645:661	arg1	oxide					668:672	ultrasmall superparamagnetic iron oxide	634:672	ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles	634:694	To this end, this work presents the modification of polycaprolactone (PCL) scaffolds with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to render them visualizable by MRI.
34096938	1	60	theme	fiber-forming	152:164	arg1	electrowriting					110:123	Melt electrowriting	105:123	Melt electrowriting (MEW)	105:129	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	1	60	theme	fiber-forming	152:164	arg1	technology					166:175	a high-resolution fiber-forming technology	134:175	a high-resolution fiber-forming technology	134:175	Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in vivo animal studies.
34096938	2	61	theme	clinical	354:361	arg1	translation					363:373	The clinical translation	350:373	The clinical translation of such constructs to the patient	350:407	The clinical translation of such constructs to the patient requires the capability to visualize them upon implantation with clinically accepted methods such as magnetic resonance imaging (MRI).
34096938	3	62	with	scaffolds	619:627	arg1	nanoparticles					682:694	ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles	634:694	ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles	634:694	To this end, this work presents the modification of polycaprolactone (PCL) scaffolds with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to render them visualizable by MRI.
34096938	3	63	theme	scaffolds	619:627	arg1	modification					580:591	the modification	576:591	the modification of polycaprolactone (PCL) scaffolds with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to render them visualizable by MRI	576:729	To this end, this work presents the modification of polycaprolactone (PCL) scaffolds with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to render them visualizable by MRI.
34096938	6	64	theme	small	1098:1102	arg1	decrease					1110:1117	small to no decrease	1098:1117	small to no decrease in the ultimate tensile strength and Young's modulus	1098:1170	Concentrations up to 0.2% caused small to no decrease in the ultimate tensile strength and Young's modulus.
34096938	0	65	theme	resonance	86:94	arg1	imaging					96:102	non-invasive magnetic resonance imaging	64:102	non-invasive magnetic resonance imaging	64:102	Visualization of USPIO-labeled melt-electrowritten scaffolds by non-invasive magnetic resonance imaging.
34096938	8	66	theme	MEW	1416:1418	arg1	grafts					1420:1425	MEW grafts	1416:1425	MEW grafts	1416:1425	This work contributes to the materials library for MEW and opens the possibility of using MRI for longitudinal monitoring of MEW grafts.
33872616	5	0	theme	cellulose-TiO2/REC	767:784	arg1	mats					808:811	cellulose-TiO2/REC composite nanofibrous mats	767:811	cellulose-TiO2/REC composite nanofibrous mats in multiple systems	767:831	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	7	1	theme	composite	1030:1038	arg1	nanofibrous					1040:1050	The composite nanofibrous	1026:1050	The composite nanofibrous	1026:1050	The composite nanofibrous mats successfully trapped TiO2 nanoparticles, and the obtained cellulose-TiO2/REC nanofibrous mats could be used to remove heavy metals from acidic wastewater.
33872616	2	2	dep	adsorbents	320:329	arg1	rectorite					361:369	rectorite	361:369	rectorite (REC)	361:375	Recoverable and efficient adsorption materials could be obtained by trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC)), in a natural polymer matrix.
33872616	2	2	dep	adsorbents	320:329	arg1	nanoparticles					343:355	nanoparticles	343:355	nanoparticles	343:355	Recoverable and efficient adsorption materials could be obtained by trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC)), in a natural polymer matrix.
33872616	2	2	dep	adsorbents	320:329	arg1	REC					372:374	REC	372:374	REC	372:374	Recoverable and efficient adsorption materials could be obtained by trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC)), in a natural polymer matrix.
33872616	5	3	theme	composite	786:794	arg1	mats					808:811	cellulose-TiO2/REC composite nanofibrous mats	767:811	cellulose-TiO2/REC composite nanofibrous mats in multiple systems	767:831	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	7	4	theme	acidic	1193:1198	arg1	wastewater					1200:1209	acidic wastewater	1193:1209	acidic wastewater	1193:1209	The composite nanofibrous mats successfully trapped TiO2 nanoparticles, and the obtained cellulose-TiO2/REC nanofibrous mats could be used to remove heavy metals from acidic wastewater.
33872616	7	5	theme	nanofibrous	1134:1144	arg1	mats					1146:1149	the obtained cellulose-TiO2/REC nanofibrous mats	1102:1149	the obtained cellulose-TiO2/REC nanofibrous mats	1102:1149	The composite nanofibrous mats successfully trapped TiO2 nanoparticles, and the obtained cellulose-TiO2/REC nanofibrous mats could be used to remove heavy metals from acidic wastewater.
33872616	4	6	theme	thermal	601:607	arg1	stability					609:617	thermal stability	601:617	thermal stability	601:617	The interactions between inorganic adsorbents and cellulose molecules improved the thermal stability, surface area, tensile strength and adsorption capacity of the mats.
33872616	7	7	used	used	1160:1163	arg2	mats					1146:1149	the obtained cellulose-TiO2/REC nanofibrous mats	1102:1149	the obtained cellulose-TiO2/REC nanofibrous mats	1102:1149	The composite nanofibrous mats successfully trapped TiO2 nanoparticles, and the obtained cellulose-TiO2/REC nanofibrous mats could be used to remove heavy metals from acidic wastewater.
33872616	5	8	from	mats	808:811	arg1	systems					825:831	multiple systems	816:831	multiple systems	816:831	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	7	9	theme	heavy	1175:1179	arg1	metals					1181:1186	heavy metals	1175:1186	heavy metals	1175:1186	The composite nanofibrous mats successfully trapped TiO2 nanoparticles, and the obtained cellulose-TiO2/REC nanofibrous mats could be used to remove heavy metals from acidic wastewater.
33872616	4	10	theme	mats	682:685	arg1	capacity					666:673	adsorption capacity	655:673	adsorption capacity	655:673	The interactions between inorganic adsorbents and cellulose molecules improved the thermal stability, surface area, tensile strength and adsorption capacity of the mats.
33872616	4	10	theme	mats	682:685	arg1	stability					609:617	thermal stability	601:617	thermal stability	601:617	The interactions between inorganic adsorbents and cellulose molecules improved the thermal stability, surface area, tensile strength and adsorption capacity of the mats.
33872616	4	10	theme	mats	682:685	arg1	area					628:631	surface area	620:631	surface area	620:631	The interactions between inorganic adsorbents and cellulose molecules improved the thermal stability, surface area, tensile strength and adsorption capacity of the mats.
33872616	4	10	theme	mats	682:685	arg1	strength					642:649	tensile strength	634:649	tensile strength	634:649	The interactions between inorganic adsorbents and cellulose molecules improved the thermal stability, surface area, tensile strength and adsorption capacity of the mats.
33872616	4	11	theme	surface	620:626	arg1	area					628:631	surface area	620:631	surface area	620:631	The interactions between inorganic adsorbents and cellulose molecules improved the thermal stability, surface area, tensile strength and adsorption capacity of the mats.
33872616	5	12	theme	Cd2+	735:738	arg1	adsorption					706:715	the adsorption	702:715	the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems	702:831	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	6	13	theme	total	930:934	arg1	capacity					947:954	The maximum total adsorption capacity	918:954	The maximum total adsorption capacity of 69.81 mg/g	918:968	The maximum total adsorption capacity of 69.81 mg/g was obtained by Cellulose-TiO2/REC2:1 nanofibrous mats.
33872616	2	14	theme	inorganic	310:318	arg1	adsorbents					320:329	inorganic adsorbents	310:329	trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC))	301:376	Recoverable and efficient adsorption materials could be obtained by trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC)), in a natural polymer matrix.
33872616	5	15	from	magnitudes	845:854	arg1	wastewater					889:898	wastewater	889:898	wastewater	889:898	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	5	16	theme	heavy	859:863	arg1	concentrations					871:884	heavy metal concentrations	859:884	heavy metal concentrations	859:884	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	1	17	theme	huge	184:187	arg1	challenge					189:197	a huge challenge	182:197	a huge challenge for ecosystems and human society	182:230	The anthropogenic release of highly toxic heavy metals into the environment presents a huge challenge for ecosystems and human society.
33872616	5	18	theme	acidic	745:750	arg1	solutions					752:760	acidic solutions	745:760	acidic solutions	745:760	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	5	19	from	adsorption	706:715	arg1	solutions					752:760	acidic solutions	745:760	acidic solutions	745:760	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	2	20	theme	natural	384:390	arg1	matrix					400:405	a natural polymer matrix	382:405	a natural polymer matrix	382:405	Recoverable and efficient adsorption materials could be obtained by trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC)), in a natural polymer matrix.
33872616	0	21	theme	cellulose	23:31	arg1	nanofibrous					43:53	TiO2/rectorite-trapped cellulose composite nanofibrous	0:53	TiO2/rectorite-trapped cellulose composite nanofibrous	0:53	TiO2/rectorite-trapped cellulose composite nanofibrous mats for multiple heavy metal adsorption.
33872616	7	22	theme	obtained	1106:1113	arg1	mats					1146:1149	the obtained cellulose-TiO2/REC nanofibrous mats	1102:1149	the obtained cellulose-TiO2/REC nanofibrous mats	1102:1149	The composite nanofibrous mats successfully trapped TiO2 nanoparticles, and the obtained cellulose-TiO2/REC nanofibrous mats could be used to remove heavy metals from acidic wastewater.
33872616	1	23	theme	anthropogenic	101:113	arg1	release					115:121	The anthropogenic release	97:121	The anthropogenic release of highly toxic heavy metals into the environment	97:171	The anthropogenic release of highly toxic heavy metals into the environment presents a huge challenge for ecosystems and human society.
33872616	6	24	theme	maximum	922:928	arg1	capacity					947:954	The maximum total adsorption capacity	918:954	The maximum total adsorption capacity of 69.81 mg/g	918:968	The maximum total adsorption capacity of 69.81 mg/g was obtained by Cellulose-TiO2/REC2:1 nanofibrous mats.
33872616	0	25	theme	TiO2/rectorite-trapped	0:21	arg1	nanofibrous					43:53	TiO2/rectorite-trapped cellulose composite nanofibrous	0:53	TiO2/rectorite-trapped cellulose composite nanofibrous	0:53	TiO2/rectorite-trapped cellulose composite nanofibrous mats for multiple heavy metal adsorption.
33872616	4	26	theme	cellulose	568:576	arg1	molecules					578:586	cellulose molecules	568:586	cellulose molecules	568:586	The interactions between inorganic adsorbents and cellulose molecules improved the thermal stability, surface area, tensile strength and adsorption capacity of the mats.
33872616	3	27	theme	composite	454:462	arg1	mats					476:479	cellulose-TiO2/REC composite nanofibrous mats	435:479	cellulose-TiO2/REC composite nanofibrous mats	435:479	In this study, a series of cellulose-TiO2/REC composite nanofibrous mats were fabricated via electrospinning.
33872616	0	28	theme	composite	33:41	arg1	nanofibrous					43:53	TiO2/rectorite-trapped cellulose composite nanofibrous	0:53	TiO2/rectorite-trapped cellulose composite nanofibrous	0:53	TiO2/rectorite-trapped cellulose composite nanofibrous mats for multiple heavy metal adsorption.
33872616	6	29	theme	nanofibrous	1008:1018	arg1	mats					1020:1023	Cellulose-TiO2/REC2:1 nanofibrous mats	986:1023	Cellulose-TiO2/REC2:1 nanofibrous mats	986:1023	The maximum total adsorption capacity of 69.81 mg/g was obtained by Cellulose-TiO2/REC2:1 nanofibrous mats.
33872616	5	30	theme	Pb2+	720:723	arg1	adsorption					706:715	the adsorption	702:715	the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems	702:831	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	3	31	theme	nanofibrous	464:474	arg1	mats					476:479	cellulose-TiO2/REC composite nanofibrous mats	435:479	cellulose-TiO2/REC composite nanofibrous mats	435:479	In this study, a series of cellulose-TiO2/REC composite nanofibrous mats were fabricated via electrospinning.
33872616	5	32	theme	nanofibrous	796:806	arg1	mats					808:811	cellulose-TiO2/REC composite nanofibrous mats	767:811	cellulose-TiO2/REC composite nanofibrous mats in multiple systems	767:831	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	6	33	theme	Cellulose-TiO2/REC2:1	986:1006	arg1	mats					1020:1023	Cellulose-TiO2/REC2:1 nanofibrous mats	986:1023	Cellulose-TiO2/REC2:1 nanofibrous mats	986:1023	The maximum total adsorption capacity of 69.81 mg/g was obtained by Cellulose-TiO2/REC2:1 nanofibrous mats.
33872616	7	34	theme	cellulose-TiO2/REC	1115:1132	arg1	mats					1146:1149	the obtained cellulose-TiO2/REC nanofibrous mats	1102:1149	the obtained cellulose-TiO2/REC nanofibrous mats	1102:1149	The composite nanofibrous mats successfully trapped TiO2 nanoparticles, and the obtained cellulose-TiO2/REC nanofibrous mats could be used to remove heavy metals from acidic wastewater.
33872616	2	35	theme	adsorption	259:268	arg1	materials					270:278	Recoverable and efficient adsorption materials	233:278	Recoverable and efficient adsorption materials	233:278	Recoverable and efficient adsorption materials could be obtained by trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC)), in a natural polymer matrix.
33872616	7	36	dep	mats	1052:1055	arg1	trapped					1070:1076	trapped	1070:1076	mats successfully trapped TiO2 nanoparticles	1052:1095	The composite nanofibrous mats successfully trapped TiO2 nanoparticles, and the obtained cellulose-TiO2/REC nanofibrous mats could be used to remove heavy metals from acidic wastewater.
33872616	5	37	theme	metal	865:869	arg1	concentrations					871:884	heavy metal concentrations	859:884	heavy metal concentrations	859:884	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	2	38	theme	polymer	392:398	arg1	matrix					400:405	a natural polymer matrix	382:405	a natural polymer matrix	382:405	Recoverable and efficient adsorption materials could be obtained by trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC)), in a natural polymer matrix.
33872616	4	39	theme	inorganic	543:551	arg1	adsorbents					553:562	inorganic adsorbents	543:562	inorganic adsorbents	543:562	The interactions between inorganic adsorbents and cellulose molecules improved the thermal stability, surface area, tensile strength and adsorption capacity of the mats.
33872616	5	40	theme	Cu2+	726:729	arg1	adsorption					706:715	the adsorption	702:715	the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems	702:831	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	4	41	dep	stability	609:617	arg1	the					597:599	the	597:599	the	597:599	The interactions between inorganic adsorbents and cellulose molecules improved the thermal stability, surface area, tensile strength and adsorption capacity of the mats.
33872616	2	42	theme	efficient	249:257	arg1	materials					270:278	Recoverable and efficient adsorption materials	233:278	Recoverable and efficient adsorption materials	233:278	Recoverable and efficient adsorption materials could be obtained by trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC)), in a natural polymer matrix.
33872616	7	43	theme	TiO2	1078:1081	arg1	nanoparticles					1083:1095	TiO2 nanoparticles	1078:1095	TiO2 nanoparticles	1078:1095	The composite nanofibrous mats successfully trapped TiO2 nanoparticles, and the obtained cellulose-TiO2/REC nanofibrous mats could be used to remove heavy metals from acidic wastewater.
33872616	3	44	theme	cellulose-TiO2/REC	435:452	arg1	mats					476:479	cellulose-TiO2/REC composite nanofibrous mats	435:479	cellulose-TiO2/REC composite nanofibrous mats	435:479	In this study, a series of cellulose-TiO2/REC composite nanofibrous mats were fabricated via electrospinning.
33872616	0	45	theme	heavy	73:77	arg1	adsorption					85:94	multiple heavy metal adsorption	64:94	multiple heavy metal adsorption	64:94	TiO2/rectorite-trapped cellulose composite nanofibrous mats for multiple heavy metal adsorption.
33872616	5	46	theme	multiple	816:823	arg1	systems					825:831	multiple systems	816:831	multiple systems	816:831	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	1	47	theme	toxic	133:137	arg1	metals					145:150	highly toxic heavy metals	126:150	highly toxic heavy metals	126:150	The anthropogenic release of highly toxic heavy metals into the environment presents a huge challenge for ecosystems and human society.
33872616	0	48	theme	multiple	64:71	arg1	adsorption					85:94	multiple heavy metal adsorption	64:94	multiple heavy metal adsorption	64:94	TiO2/rectorite-trapped cellulose composite nanofibrous mats for multiple heavy metal adsorption.
33872616	3	49	theme	mats	476:479	arg1	series					425:430	a series	423:430	a series of cellulose-TiO2/REC composite nanofibrous mats	423:479	In this study, a series of cellulose-TiO2/REC composite nanofibrous mats were fabricated via electrospinning.
33872616	2	50	theme	Recoverable	233:243	arg1	materials					270:278	Recoverable and efficient adsorption materials	233:278	Recoverable and efficient adsorption materials	233:278	Recoverable and efficient adsorption materials could be obtained by trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC)), in a natural polymer matrix.
33872616	1	51	theme	heavy	139:143	arg1	metals					145:150	highly toxic heavy metals	126:150	highly toxic heavy metals	126:150	The anthropogenic release of highly toxic heavy metals into the environment presents a huge challenge for ecosystems and human society.
33872616	6	52	theme	mg/g	965:968	arg1	capacity					947:954	The maximum total adsorption capacity	918:954	The maximum total adsorption capacity of 69.81 mg/g	918:968	The maximum total adsorption capacity of 69.81 mg/g was obtained by Cellulose-TiO2/REC2:1 nanofibrous mats.
33872616	1	53	theme	metals	145:150	arg1	release					115:121	The anthropogenic release	97:121	The anthropogenic release of highly toxic heavy metals into the environment	97:171	The anthropogenic release of highly toxic heavy metals into the environment presents a huge challenge for ecosystems and human society.
33872616	5	54	from	solutions	752:760	arg1	Pb2+					720:723	Pb2+	720:723	Pb2+	720:723	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	5	54	from	solutions	752:760	arg1	adsorption					706:715	the adsorption	702:715	the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems	702:831	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	5	54	from	solutions	752:760	arg1	Cd2+					735:738	Cd2+	735:738	Cd2+	735:738	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	5	54	from	solutions	752:760	arg1	Cu2+					726:729	Cu2+	726:729	Cu2+	726:729	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	2	55	dep	TiO2	338:341	arg1	e.g.					332:335	e.g.	332:335	e.g.	332:335	Recoverable and efficient adsorption materials could be obtained by trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC)), in a natural polymer matrix.
33872616	5	56	theme	concentrations	871:884	arg1	magnitudes					845:854	the magnitudes	841:854	the magnitudes of heavy metal concentrations in wastewater	841:898	We focused on the adsorption of Pb2+, Cu2+ and Cd2+ from acidic solutions onto cellulose-TiO2/REC composite nanofibrous mats in multiple systems because the magnitudes of heavy metal concentrations in wastewater typically varied.
33872616	4	57	theme	adsorption	655:664	arg1	capacity					666:673	adsorption capacity	655:673	adsorption capacity	655:673	The interactions between inorganic adsorbents and cellulose molecules improved the thermal stability, surface area, tensile strength and adsorption capacity of the mats.
33872616	2	58	dep	trapping	301:308	arg1	adsorbents					320:329	inorganic adsorbents	310:329	trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC))	301:376	Recoverable and efficient adsorption materials could be obtained by trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC)), in a natural polymer matrix.
33872616	6	59	theme	adsorption	936:945	arg1	capacity					947:954	The maximum total adsorption capacity	918:954	The maximum total adsorption capacity of 69.81 mg/g	918:968	The maximum total adsorption capacity of 69.81 mg/g was obtained by Cellulose-TiO2/REC2:1 nanofibrous mats.
33872616	0	60	theme	metal	79:83	arg1	adsorption					85:94	multiple heavy metal adsorption	64:94	multiple heavy metal adsorption	64:94	TiO2/rectorite-trapped cellulose composite nanofibrous mats for multiple heavy metal adsorption.
33872616	4	61	theme	tensile	634:640	arg1	strength					642:649	tensile strength	634:649	tensile strength	634:649	The interactions between inorganic adsorbents and cellulose molecules improved the thermal stability, surface area, tensile strength and adsorption capacity of the mats.
32335108	3	0	theme	acid	716:719	arg1	hydrolysis					721:730	acid hydrolysis	716:730	acid hydrolysis	716:730	Firstly, CHWs with different chemical structure, including positively charged whiskers (CHWs and CHWs-D/60 min) and negatively charged whiskers (mCHWs), were designed via acid hydrolysis, deacetylation, and maleation, respectively.
32335108	0	1	with	properties	35:44	arg1	chargeability					104:116	chargeability	104:116	chargeability	104:116	Liquid crystalline and rheological properties of chitin whiskers with different chemical structures and chargeability.
32335108	0	1	with	properties	35:44	arg1	structures					89:98	different chemical structures	70:98	different chemical structures	70:98	Liquid crystalline and rheological properties of chitin whiskers with different chemical structures and chargeability.
32335108	1	2	theme	chitin	172:177	arg1	CHWs					189:192	CHWs	189:192	CHWs	189:192	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	1	2	theme	chitin	172:177	arg1	whiskers					179:186	chitin whiskers	172:186	chitin whiskers (CHWs)	172:193	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	1	3	theme	ordered	258:264	arg1	materials					276:284	composite materials	266:284	composite materials	266:284	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	0	4	theme	chemical	80:87	arg1	structures					89:98	different chemical structures	70:98	different chemical structures	70:98	Liquid crystalline and rheological properties of chitin whiskers with different chemical structures and chargeability.
32335108	5	5	theme	high	923:926	arg1	potential					933:941	high zeta potential	923:941	high zeta potential	923:941	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	1	6	theme	whiskers	179:186	arg1	significant					199:209	significant	199:209	significant	199:209	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	1	6	theme	whiskers	179:186	arg1	crystalline					130:140	The liquid crystalline and rheological properties	119:167	crystalline	130:140	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	1	6	theme	whiskers	179:186	arg1	properties					158:167	The liquid crystalline and rheological properties	119:167	properties	158:167	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	1	7	theme	composite	266:274	arg1	materials					276:284	composite materials	266:284	composite materials	266:284	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	8	8	dep	structure	1638:1646	arg1	the					1625:1627	the	1625:1627	the	1625:1627	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	8	9	theme	rheological	1535:1545	arg1	properties					1547:1556	rheological properties	1535:1556	rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions	1535:1610	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	5	10	with	suspensions	906:916	arg1	potential					933:941	high zeta potential	923:941	high zeta potential	923:941	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	6	11	theme	suspensions	1161:1171	arg1	values					1116:1121	The viscosity, G', and G" values	1090:1121	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation	1090:1196	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	6	11	theme	suspensions	1161:1171	arg1	lower					1203:1207	lower	1203:1207	lower	1203:1207	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	5	12	theme	nematic	988:994	arg1	crystals					1003:1010	chiral nematic liquid crystals	981:1010	chiral nematic liquid crystals	981:1010	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	5	13	theme	chiral	981:986	arg1	crystals					1003:1010	chiral nematic liquid crystals	981:1010	chiral nematic liquid crystals	981:1010	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	1	14	theme	materials	276:284	arg1	fabrication					236:246	fabrication	236:246	fabrication of highly ordered composite materials and optical components	236:307	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	5	15	theme	liquid	962:967	arg1	crystals					969:976	nematic liquid crystals	954:976	nematic liquid crystals	954:976	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	8	16	theme	CHWs	1561:1564	arg1	properties					1547:1556	rheological properties	1535:1556	rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions	1535:1610	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	8	16	theme	CHWs	1561:1564	arg1	effects					1472:1478	the effects	1468:1478	the effects of ionic strength and pH on the liquid crystalline	1468:1529	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	5	17	theme	liquid	996:1001	arg1	crystals					1003:1010	chiral nematic liquid crystals	981:1010	chiral nematic liquid crystals	981:1010	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	3	18	theme	different	564:572	arg1	structure					583:591	different chemical structure	564:591	different chemical structure	564:591	Firstly, CHWs with different chemical structure, including positively charged whiskers (CHWs and CHWs-D/60 min) and negatively charged whiskers (mCHWs), were designed via acid hydrolysis, deacetylation, and maleation, respectively.
32335108	5	19	theme	nematic	954:960	arg1	crystals					969:976	nematic liquid crystals	954:976	nematic liquid crystals	954:976	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	2	20	theme	CHWs	539:542	arg1	crystalline					497:507	the liquid crystalline	486:507	the liquid crystalline	486:507	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	2	20	theme	CHWs	539:542	arg1	properties					525:534	rheological properties	513:534	rheological properties of CHWs	513:542	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	6	21	theme	G	1105:1105	arg1	values					1116:1121	The viscosity, G', and G" values	1090:1121	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation	1090:1196	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	6	21	theme	G	1105:1105	arg1	lower					1203:1207	lower	1203:1207	lower	1203:1207	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	3	22	dep	whiskers	623:630	arg1	whiskers					623:630	positively charged whiskers	604:630	positively charged whiskers (CHWs and CHWs-D/60 min)	604:655	Firstly, CHWs with different chemical structure, including positively charged whiskers (CHWs and CHWs-D/60 min) and negatively charged whiskers (mCHWs), were designed via acid hydrolysis, deacetylation, and maleation, respectively.
32335108	3	22	dep	whiskers	623:630	arg1	CHWs-D/60 min					642:654	CHWs-D/60 min	642:654	CHWs-D/60 min	642:654	Firstly, CHWs with different chemical structure, including positively charged whiskers (CHWs and CHWs-D/60 min) and negatively charged whiskers (mCHWs), were designed via acid hydrolysis, deacetylation, and maleation, respectively.
32335108	3	22	dep	whiskers	623:630	arg1	CHWs					633:636	CHWs	633:636	CHWs	633:636	Firstly, CHWs with different chemical structure, including positively charged whiskers (CHWs and CHWs-D/60 min) and negatively charged whiskers (mCHWs), were designed via acid hydrolysis, deacetylation, and maleation, respectively.
32335108	2	23	theme	zeta	403:406	arg1	potential					408:416	zeta potential	403:416	zeta potential	403:416	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	8	24	theme	CHWs-D/60 min	1567:1579	arg1	properties					1547:1556	rheological properties	1535:1556	rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions	1535:1610	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	8	24	theme	CHWs-D/60 min	1567:1579	arg1	effects					1472:1478	the effects	1468:1478	the effects of ionic strength and pH on the liquid crystalline	1468:1529	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	8	25	theme	whiskers	1669:1676	arg1	chargeability					1652:1664	chargeability	1652:1664	chargeability	1652:1664	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	8	25	theme	whiskers	1669:1676	arg1	structure					1638:1646	chemical structure	1629:1646	chemical structure	1629:1646	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	2	26	theme	zwitterionic	459:470	arg1	character					472:480	zwitterionic character	459:480	zwitterionic character	459:480	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	8	27	theme	pH	1502:1503	arg1	properties					1547:1556	rheological properties	1535:1556	rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions	1535:1610	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	8	27	theme	pH	1502:1503	arg1	effects					1472:1478	the effects	1468:1478	the effects of ionic strength and pH on the liquid crystalline	1468:1529	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	6	28	dep	CHWs	1130:1133	arg1	the					1126:1128	the	1126:1128	the	1126:1128	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	8	29	from	properties	1547:1556	arg1	crystalline					1519:1529	the liquid crystalline	1508:1529	the liquid crystalline	1508:1529	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	6	30	theme	aqueous	1153:1159	arg1	suspensions					1161:1171	CHWs-D/60 min aqueous suspensions	1139:1171	CHWs-D/60 min aqueous suspensions	1139:1171	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	2	31	from	influence	352:360	arg1	crystalline					497:507	the liquid crystalline	486:507	the liquid crystalline	486:507	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	2	31	from	influence	352:360	arg1	properties					525:534	rheological properties	513:534	rheological properties of CHWs	513:542	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	2	32	theme	work	326:329	arg1	aim					314:316	The aim	310:316	The aim of this work	310:329	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	2	33	theme	chargeability	388:400	arg1	influence					352:360	the influence	348:360	the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs	348:542	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	0	34	theme	Liquid	0:5	arg1	crystalline					7:17	Liquid crystalline	0:17	Liquid crystalline	0:17	Liquid crystalline and rheological properties of chitin whiskers with different chemical structures and chargeability.
32335108	1	35	theme	optical	290:296	arg1	components					298:307	optical components	290:307	optical components	290:307	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	7	36	dep	electronegativity	1403:1419	arg1	the					1399:1401	the	1399:1401	the	1399:1401	However, the mCHWs exhibited different changes in their rheological properties under protonation or deprotonation due to the electronegativity and zwitterionic characteristics.
32335108	6	37	theme	CHWs-D/60 min	1139:1151	arg1	suspensions					1161:1171	CHWs-D/60 min aqueous suspensions	1139:1171	CHWs-D/60 min aqueous suspensions	1139:1171	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	8	38	from	effects	1472:1478	arg1	crystalline					1519:1529	the liquid crystalline	1508:1529	the liquid crystalline	1508:1529	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	5	39	theme	aqueous	898:904	arg1	suspensions					906:916	The whisker aqueous suspensions	886:916	The whisker aqueous suspensions with high zeta potential	886:941	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	0	40	theme	rheological	23:33	arg1	properties					35:44	rheological properties	23:44	rheological properties	23:44	Liquid crystalline and rheological properties of chitin whiskers with different chemical structures and chargeability.
32335108	1	41	theme	components	298:307	arg1	fabrication					236:246	fabrication	236:246	fabrication of highly ordered composite materials and optical components	236:307	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	3	42	theme	chemical	574:581	arg1	structure					583:591	different chemical structure	564:591	different chemical structure	564:591	Firstly, CHWs with different chemical structure, including positively charged whiskers (CHWs and CHWs-D/60 min) and negatively charged whiskers (mCHWs), were designed via acid hydrolysis, deacetylation, and maleation, respectively.
32335108	6	43	theme	"	1114:1114	arg1	values					1116:1121	The viscosity, G', and G" values	1090:1121	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation	1090:1196	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	6	43	theme	"	1114:1114	arg1	lower					1203:1207	lower	1203:1207	lower	1203:1207	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	8	44	theme	aqueous	1592:1598	arg1	suspensions					1600:1610	mCHWs aqueous suspensions	1586:1610	mCHWs aqueous suspensions	1586:1610	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	7	45	from	changes	1317:1323	arg1	properties					1346:1355	their rheological properties	1328:1355	their rheological properties	1328:1355	However, the mCHWs exhibited different changes in their rheological properties under protonation or deprotonation due to the electronegativity and zwitterionic characteristics.
32335108	3	46	theme	charged	672:678	arg1	mCHWs					690:694	mCHWs	690:694	mCHWs	690:694	Firstly, CHWs with different chemical structure, including positively charged whiskers (CHWs and CHWs-D/60 min) and negatively charged whiskers (mCHWs), were designed via acid hydrolysis, deacetylation, and maleation, respectively.
32335108	3	46	theme	charged	672:678	arg1	whiskers					680:687	negatively charged whiskers	661:687	negatively charged whiskers (mCHWs)	661:695	Firstly, CHWs with different chemical structure, including positively charged whiskers (CHWs and CHWs-D/60 min) and negatively charged whiskers (mCHWs), were designed via acid hydrolysis, deacetylation, and maleation, respectively.
32335108	5	47	theme	zeta	928:931	arg1	potential					933:941	high zeta potential	923:941	high zeta potential	923:941	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	6	48	theme	G	1113:1113	arg1	"					1114:1114	G"	1113:1114	G"	1113:1114	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	2	49	theme	liquid	490:495	arg1	crystalline					497:507	the liquid crystalline	486:507	the liquid crystalline	486:507	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	8	50	theme	mCHWs	1586:1590	arg1	suspensions					1600:1610	mCHWs aqueous suspensions	1586:1610	mCHWs aqueous suspensions	1586:1610	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	5	51	theme	zeta	1036:1039	arg1	potential					1041:1049	low zeta potential	1032:1049	low zeta potential	1032:1049	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	7	52	theme	zwitterionic	1425:1436	arg1	characteristics					1438:1452	zwitterionic characteristics	1425:1452	zwitterionic characteristics	1425:1452	However, the mCHWs exhibited different changes in their rheological properties under protonation or deprotonation due to the electronegativity and zwitterionic characteristics.
32335108	3	53	with	CHWs	554:557	arg1	structure					583:591	different chemical structure	564:591	different chemical structure	564:591	Firstly, CHWs with different chemical structure, including positively charged whiskers (CHWs and CHWs-D/60 min) and negatively charged whiskers (mCHWs), were designed via acid hydrolysis, deacetylation, and maleation, respectively.
32335108	5	54	theme	whisker	890:896	arg1	suspensions					906:916	The whisker aqueous suspensions	886:916	The whisker aqueous suspensions with high zeta potential	886:941	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	4	55	theme	whiskers	822:829	arg1	chargeability					795:807	the chargeability	791:807	the chargeability of the above whiskers	791:829	Subsequently, the chargeability of the above whiskers was further regulated by protonation or deprotonation.
32335108	8	56	theme	ionic	1483:1487	arg1	strength					1489:1496	ionic strength	1483:1496	ionic strength	1483:1496	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	6	57	theme	viscosity	1094:1102	arg1	values					1116:1121	The viscosity, G', and G" values	1090:1121	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation	1090:1196	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	6	57	theme	viscosity	1094:1102	arg1	lower					1203:1207	lower	1203:1207	lower	1203:1207	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	0	58	theme	whiskers	56:63	arg1	crystalline					7:17	Liquid crystalline	0:17	Liquid crystalline	0:17	Liquid crystalline and rheological properties of chitin whiskers with different chemical structures and chargeability.
32335108	0	58	theme	whiskers	56:63	arg1	properties					35:44	rheological properties	23:44	rheological properties	23:44	Liquid crystalline and rheological properties of chitin whiskers with different chemical structures and chargeability.
32335108	8	59	theme	suspensions	1600:1610	arg1	properties					1547:1556	rheological properties	1535:1556	rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions	1535:1610	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	8	59	theme	suspensions	1600:1610	arg1	effects					1472:1478	the effects	1468:1478	the effects of ionic strength and pH on the liquid crystalline	1468:1529	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	8	60	theme	strength	1489:1496	arg1	properties					1547:1556	rheological properties	1535:1556	rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions	1535:1610	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	8	60	theme	strength	1489:1496	arg1	effects					1472:1478	the effects	1468:1478	the effects of ionic strength and pH on the liquid crystalline	1468:1529	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	1	61	from	application	221:231	arg1	fabrication					236:246	fabrication	236:246	fabrication of highly ordered composite materials and optical components	236:307	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	1	62	theme	liquid	123:128	arg1	crystalline					130:140	The liquid crystalline and rheological properties	119:167	crystalline	130:140	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	1	62	theme	liquid	123:128	arg1	significant					199:209	significant	199:209	significant	199:209	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	0	63	theme	chitin	49:54	arg1	whiskers					56:63	chitin whiskers	49:63	chitin whiskers	49:63	Liquid crystalline and rheological properties of chitin whiskers with different chemical structures and chargeability.
32335108	7	64	theme	rheological	1334:1344	arg1	properties					1346:1355	their rheological properties	1328:1355	their rheological properties	1328:1355	However, the mCHWs exhibited different changes in their rheological properties under protonation or deprotonation due to the electronegativity and zwitterionic characteristics.
32335108	5	65	theme	liquid	1058:1063	arg1	characteristics					1073:1087	no liquid crystal characteristics	1055:1087	no liquid crystal characteristics	1055:1087	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	3	66	theme	charged	615:621	arg1	whiskers					623:630	positively charged whiskers	604:630	positively charged whiskers (CHWs and CHWs-D/60 min)	604:655	Firstly, CHWs with different chemical structure, including positively charged whiskers (CHWs and CHWs-D/60 min) and negatively charged whiskers (mCHWs), were designed via acid hydrolysis, deacetylation, and maleation, respectively.
32335108	3	66	theme	charged	615:621	arg1	CHWs-D/60 min					642:654	CHWs-D/60 min	642:654	CHWs-D/60 min	642:654	Firstly, CHWs with different chemical structure, including positively charged whiskers (CHWs and CHWs-D/60 min) and negatively charged whiskers (mCHWs), were designed via acid hydrolysis, deacetylation, and maleation, respectively.
32335108	3	66	theme	charged	615:621	arg1	CHWs					633:636	CHWs	633:636	CHWs	633:636	Firstly, CHWs with different chemical structure, including positively charged whiskers (CHWs and CHWs-D/60 min) and negatively charged whiskers (mCHWs), were designed via acid hydrolysis, deacetylation, and maleation, respectively.
32335108	0	67	with	crystalline	7:17	arg1	chargeability					104:116	chargeability	104:116	chargeability	104:116	Liquid crystalline and rheological properties of chitin whiskers with different chemical structures and chargeability.
32335108	0	67	with	crystalline	7:17	arg1	structures					89:98	different chemical structures	70:98	different chemical structures	70:98	Liquid crystalline and rheological properties of chitin whiskers with different chemical structures and chargeability.
32335108	5	68	theme	crystal	1065:1071	arg1	characteristics					1073:1087	no liquid crystal characteristics	1055:1087	no liquid crystal characteristics	1055:1087	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	2	69	dep	chargeability	388:400	arg1	electronegativity					438:454	electronegativity	438:454	electronegativity	438:454	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	2	69	dep	chargeability	388:400	arg1	character					472:480	zwitterionic character	459:480	zwitterionic character	459:480	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	2	69	dep	chargeability	388:400	arg1	electropositivity					419:435	electropositivity	419:435	electropositivity	419:435	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	2	69	dep	chargeability	388:400	arg1	potential					408:416	zeta potential	403:416	zeta potential	403:416	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	6	70	theme	corresponding	1227:1239	arg1	whiskers					1241:1248	the corresponding whiskers	1223:1248	the corresponding whiskers treated with deprotonation	1223:1275	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	5	71	contain	had	1051:1053	arg1	those					1021:1025	those	1021:1025	those	1021:1025	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	5	71	contain	had	1051:1053	arg2	characteristics					1073:1087	no liquid crystal characteristics	1055:1087	no liquid crystal characteristics	1055:1087	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	5	72	dep	behaved	943:949	arg1	whereas					1013:1019	whereas	1013:1019	whereas	1013:1019	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	8	73	theme	liquid	1512:1517	arg1	crystalline					1519:1529	the liquid crystalline	1508:1529	the liquid crystalline	1508:1529	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	1	74	theme	rheological	146:156	arg1	properties					158:167	The liquid crystalline and rheological properties	119:167	properties	158:167	The liquid crystalline and rheological properties of chitin whiskers (CHWs) are significant for their application in fabrication of highly ordered composite materials and optical components.
32335108	8	75	theme	chemical	1629:1636	arg1	structure					1638:1646	chemical structure	1629:1646	chemical structure	1629:1646	In addition, the effects of ionic strength and pH on the liquid crystalline and rheological properties of CHWs, CHWs-D/60 min, and mCHWs aqueous suspensions varied since the chemical structure and chargeability of whiskers differ.
32335108	0	76	theme	different	70:78	arg1	structures					89:98	different chemical structures	70:98	different chemical structures	70:98	Liquid crystalline and rheological properties of chitin whiskers with different chemical structures and chargeability.
32335108	7	77	theme	different	1307:1315	arg1	changes					1317:1323	different changes	1307:1323	different changes in their rheological properties	1307:1355	However, the mCHWs exhibited different changes in their rheological properties under protonation or deprotonation due to the electronegativity and zwitterionic characteristics.
32335108	4	78	theme	above	816:820	arg1	whiskers					822:829	the above whiskers	812:829	the above whiskers	812:829	Subsequently, the chargeability of the above whiskers was further regulated by protonation or deprotonation.
32335108	2	79	theme	structure	374:382	arg1	influence					352:360	the influence	348:360	the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs	348:542	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	2	80	theme	rheological	513:523	arg1	properties					525:534	rheological properties	513:534	rheological properties of CHWs	513:542	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
32335108	6	81	theme	CHWs	1130:1133	arg1	values					1116:1121	The viscosity, G', and G" values	1090:1121	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation	1090:1196	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	6	81	theme	CHWs	1130:1133	arg1	lower					1203:1207	lower	1203:1207	lower	1203:1207	The viscosity, G', and G" values of the CHWs and CHWs-D/60 min aqueous suspensions treated with protonation were lower than those of the corresponding whiskers treated with deprotonation.
32335108	5	82	theme	low	1032:1034	arg1	potential					1041:1049	low zeta potential	1032:1049	low zeta potential	1032:1049	The whisker aqueous suspensions with high zeta potential behaved as nematic liquid crystals or chiral nematic liquid crystals, whereas those with low zeta potential had no liquid crystal characteristics.
32335108	2	83	theme	chemical	365:372	arg1	structure					374:382	chemical structure	365:382	chemical structure	365:382	The aim of this work was to elucidate the influence of chemical structure and chargeability (zeta potential, electropositivity, electronegativity or zwitterionic character) on the liquid crystalline and rheological properties of CHWs.
33922254	4	0	theme	lactic	479:484	arg1	acids					513:517	lactic, acetic, malic, and formic acids	479:517	lactic, acetic, malic, and formic acids	479:517	Solutions of lactic, acetic, malic, and formic acids in concentrations of 3% wt.
33922254	8	1	theme	spectroscopy	928:939	arg1	analysis					941:948	1H-NMR spectroscopy analysis	921:948	1H-NMR spectroscopy analysis	921:948	The chemical structure and DDA of the initial chitosan were analyzed using 1H-NMR spectroscopy analysis.
33922254	6	2	theme	chromatographic	672:686	arg1	analysis					688:695	GPC/SEC chromatographic analysis	664:695	GPC/SEC chromatographic analysis	664:695	The progress of degradation was determined based on the intrinsic viscosity measurement, GPC/SEC chromatographic analysis, and their correlation.
33922254	10	3	theme	appropriate	1282:1292	arg1	medium					1294:1299	an appropriate medium	1279:1299	an appropriate medium	1279:1299	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	4	4	theme	%	541:541	arg1	wt					543:544	3% wt	540:544	3% wt	540:544	Solutions of lactic, acetic, malic, and formic acids in concentrations of 3% wt.
33922254	8	5	theme	1H-NMR	921:926	arg1	analysis					941:948	1H-NMR spectroscopy analysis	921:948	1H-NMR spectroscopy analysis	921:948	The chemical structure and DDA of the initial chitosan were analyzed using 1H-NMR spectroscopy analysis.
33922254	10	6	theme	medium	1294:1299	arg1	selection					1266:1274	the selection	1262:1274	the selection of an appropriate medium	1262:1299	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	2	7	theme	dissociation	339:350	arg1	constants					352:360	the different acid dissociation constants	320:360	the different acid dissociation constants (pKa values)	320:373	More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values).
33922254	2	7	theme	dissociation	339:350	arg1	values					367:372	pKa values	363:372	pKa values	363:372	More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values).
33922254	4	8	theme	3	540:540	arg1	%					541:541	%	541:541	%	541:541	Solutions of lactic, acetic, malic, and formic acids in concentrations of 3% wt.
33922254	4	9	theme	acetic	487:492	arg1	acids					513:517	lactic, acetic, malic, and formic acids	479:517	lactic, acetic, malic, and formic acids	479:517	Solutions of lactic, acetic, malic, and formic acids in concentrations of 3% wt.
33922254	10	10	theme	stable	1328:1333	arg1	process					1344:1350	an effective and stable spinning process	1311:1350	an effective and stable spinning process	1311:1350	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	7	11	dep	168	830:832	arg1	to					827:828	to	827:828	to	827:828	Changes in the viscosity parameters were performed at a temperature of 20 °C ± 1 °C and a timeframe of up to 168 h (7 days).
33922254	9	12	theme	micro-	1064:1069	arg1	production					1050:1059	production	1050:1059	production of micro- and nano-capsules for drug delivery	1050:1105	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	9	12	theme	micro-	1064:1069	arg1	types					1118:1122	other types	1112:1122	other types of processing	1112:1136	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	9	12	theme	micro-	1064:1069	arg1	electrospinning					1033:1047	electrospinning	1033:1047	electrospinning	1033:1047	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	8	13	theme	initial	884:890	arg1	chitosan					892:899	the initial chitosan	880:899	the initial chitosan	880:899	The chemical structure and DDA of the initial chitosan were analyzed using 1H-NMR spectroscopy analysis.
33922254	6	14	theme	GPC/SEC	664:670	arg1	analysis					688:695	GPC/SEC chromatographic analysis	664:695	GPC/SEC chromatographic analysis	664:695	The progress of degradation was determined based on the intrinsic viscosity measurement, GPC/SEC chromatographic analysis, and their correlation.
33922254	4	15	theme	wt	543:544	arg1	concentrations					522:535	concentrations	522:535	concentrations of 3% wt	522:544	Solutions of lactic, acetic, malic, and formic acids in concentrations of 3% wt.
33922254	7	16	theme	°C	802:803	arg1	temperature					777:787	a temperature	775:787	a temperature of 20 °C ± 1 °C	775:803	Changes in the viscosity parameters were performed at a temperature of 20 °C ± 1 °C and a timeframe of up to 168 h (7 days).
33922254	7	16	theme	°C	802:803	arg1	timeframe					811:819	a timeframe	809:819	a timeframe of up to 168 h (7 days)	809:843	Changes in the viscosity parameters were performed at a temperature of 20 °C ± 1 °C and a timeframe of up to 168 h (7 days).
33922254	3	17	theme	acid	450:453	arg1	solutions					455:463	acetic acid solutions	443:463	acetic acid solutions	443:463	The scientists involved in chitosan to date have focused mainly on acetic acid solutions.
33922254	10	18	theme	spinning	1335:1342	arg1	process					1344:1350	an effective and stable spinning process	1311:1350	an effective and stable spinning process	1311:1350	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	10	19	theme	constant	1187:1194	arg1	influence					1157:1165	the influence	1153:1165	the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation	1153:1249	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	4	20	from	Solutions	466:474	arg1	concentrations					522:535	concentrations	522:535	concentrations of 3% wt	522:544	Solutions of lactic, acetic, malic, and formic acids in concentrations of 3% wt.
33922254	1	21	from	degradation	116:126	arg1	solutions					144:152	organic acid solutions	131:152	organic acid solutions according to their different dissociation characteristics	131:210	This paper presents a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics.
33922254	7	22	theme	±	798:798	arg1	°C					802:803	20 °C ± 1 °C	792:803	20 °C ± 1 °C	792:803	Changes in the viscosity parameters were performed at a temperature of 20 °C ± 1 °C and a timeframe of up to 168 h (7 days).
33922254	0	23	from	Degradation	25:35	arg1	Solutions					53:61	Organic Acid Solutions	40:61	Organic Acid Solutions	40:61	The Kinetics of Chitosan Degradation in Organic Acid Solutions.
33922254	8	24	theme	chitosan	892:899	arg1	DDA					873:875	DDA	873:875	DDA	873:875	The chemical structure and DDA of the initial chitosan were analyzed using 1H-NMR spectroscopy analysis.
33922254	8	24	theme	chitosan	892:899	arg1	structure					859:867	chemical structure	850:867	chemical structure	850:867	The chemical structure and DDA of the initial chitosan were analyzed using 1H-NMR spectroscopy analysis.
33922254	6	25	theme	viscosity	641:649	arg1	measurement					651:661	the intrinsic viscosity measurement	627:661	the intrinsic viscosity measurement	627:661	The progress of degradation was determined based on the intrinsic viscosity measurement, GPC/SEC chromatographic analysis, and their correlation.
33922254	1	26	theme	different	173:181	arg1	characteristics					196:210	their different dissociation characteristics	167:210	their different dissociation characteristics	167:210	This paper presents a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics.
33922254	9	27	theme	nano-capsules	1075:1087	arg1	production					1050:1059	production	1050:1059	production of micro- and nano-capsules for drug delivery	1050:1105	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	9	27	theme	nano-capsules	1075:1087	arg1	types					1118:1122	other types	1112:1122	other types of processing	1112:1136	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	9	27	theme	nano-capsules	1075:1087	arg1	electrospinning					1033:1047	electrospinning	1033:1047	electrospinning	1033:1047	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	2	28	theme	process	299:305	arg1	kinetics					271:278	the kinetics	267:278	the kinetics of the degradation process depending on the different acid dissociation constants (pKa values)	267:373	More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values).
33922254	6	29	theme	intrinsic	631:639	arg1	measurement					651:661	the intrinsic viscosity measurement	627:661	the intrinsic viscosity measurement	627:661	The progress of degradation was determined based on the intrinsic viscosity measurement, GPC/SEC chromatographic analysis, and their correlation.
33922254	1	30	theme	dissociation	183:194	arg1	characteristics					196:210	their different dissociation characteristics	167:210	their different dissociation characteristics	167:210	This paper presents a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics.
33922254	0	31	theme	Chitosan	16:23	arg1	Kinetics					4:11	The Kinetics	0:11	The Kinetics of Chitosan	0:23	The Kinetics of Chitosan Degradation in Organic Acid Solutions.
33922254	4	32	theme	acids	513:517	arg1	Solutions					466:474	Solutions	466:474	Solutions of lactic, acetic, malic, and formic acids in concentrations of 3% wt	466:544	Solutions of lactic, acetic, malic, and formic acids in concentrations of 3% wt.
33922254	10	33	theme	degradation	1388:1398	arg1	unfavorable					1403:1413	unfavorable	1403:1413	unfavorable	1403:1413	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	10	33	theme	degradation	1388:1398	arg1	occurrence					1366:1375	the occurrence	1362:1375	the occurrence of polymer degradation	1362:1398	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	9	34	theme	drug	1093:1096	arg1	delivery					1098:1105	drug delivery	1093:1105	drug delivery	1093:1105	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	2	35	theme	degradation	287:297	arg1	process					299:305	the degradation process	283:305	the degradation process	283:305	More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values).
33922254	7	36	theme	°C	795:796	arg1	°C					802:803	20 °C ± 1 °C	792:803	20 °C ± 1 °C	792:803	Changes in the viscosity parameters were performed at a temperature of 20 °C ± 1 °C and a timeframe of up to 168 h (7 days).
33922254	3	37	theme	acetic	443:448	arg1	solutions					455:463	acetic acid solutions	443:463	acetic acid solutions	443:463	The scientists involved in chitosan to date have focused mainly on acetic acid solutions.
33922254	10	38	from	process	1344:1350	arg1	unfavorable					1403:1413	unfavorable	1403:1413	unfavorable	1403:1413	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	10	38	from	process	1344:1350	arg1	occurrence					1366:1375	the occurrence	1362:1375	the occurrence of polymer degradation	1362:1398	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	10	39	theme	polymer	1380:1386	arg1	degradation					1388:1398	polymer degradation	1380:1398	polymer degradation	1380:1398	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	9	40	theme	types	1118:1122	arg1	purpose					1022:1028	the purpose	1018:1028	the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing	1018:1136	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	10	41	from	influence	1157:1165	arg1	kinetics					1218:1225	the kinetics	1214:1225	the kinetics of chitosan degradation	1214:1249	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	10	42	theme	solvent	1203:1209	arg1	constant					1187:1194	the dissociation constant	1170:1194	the dissociation constant of the solvent	1170:1209	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	1	43	theme	organic	131:137	arg1	solutions					144:152	organic acid solutions	131:152	organic acid solutions according to their different dissociation characteristics	131:210	This paper presents a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics.
33922254	10	44	from	unfavorable	1403:1413	arg1	process					1344:1350	an effective and stable spinning process	1311:1350	an effective and stable spinning process	1311:1350	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	2	45	theme	different	324:332	arg1	constants					352:360	the different acid dissociation constants	320:360	the different acid dissociation constants (pKa values)	320:373	More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values).
33922254	2	45	theme	different	324:332	arg1	values					367:372	pKa values	363:372	pKa values	363:372	More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values).
33922254	1	46	theme	comparative	86:96	arg1	study					98:102	a comparative study	84:102	a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics	84:210	This paper presents a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics.
33922254	7	47	theme	viscosity	736:744	arg1	parameters					746:755	the viscosity parameters	732:755	the viscosity parameters	732:755	Changes in the viscosity parameters were performed at a temperature of 20 °C ± 1 °C and a timeframe of up to 168 h (7 days).
33922254	9	48	theme	processing	1127:1136	arg1	production					1050:1059	production	1050:1059	production of micro- and nano-capsules for drug delivery	1050:1105	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	9	48	theme	processing	1127:1136	arg1	types					1118:1122	other types	1112:1122	other types of processing	1112:1136	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	9	48	theme	processing	1127:1136	arg1	electrospinning					1033:1047	electrospinning	1033:1047	electrospinning	1033:1047	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	10	49	theme	degradation	1239:1249	arg1	kinetics					1218:1225	the kinetics	1214:1225	the kinetics of chitosan degradation	1214:1249	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	0	50	theme	Acid	48:51	arg1	Solutions					53:61	Organic Acid Solutions	40:61	Organic Acid Solutions	40:61	The Kinetics of Chitosan Degradation in Organic Acid Solutions.
33922254	4	51	theme	malic	495:499	arg1	acids					513:517	lactic, acetic, malic, and formic acids	479:517	lactic, acetic, malic, and formic acids	479:517	Solutions of lactic, acetic, malic, and formic acids in concentrations of 3% wt.
33922254	8	52	dep	structure	859:867	arg1	The					846:848	The	846:848	The	846:848	The chemical structure and DDA of the initial chitosan were analyzed using 1H-NMR spectroscopy analysis.
33922254	10	53	theme	chitosan	1230:1237	arg1	degradation					1239:1249	chitosan degradation	1230:1249	chitosan degradation	1230:1249	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	2	54	theme	acid	334:337	arg1	constants					352:360	the different acid dissociation constants	320:360	the different acid dissociation constants (pKa values)	320:373	More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values).
33922254	2	54	theme	acid	334:337	arg1	values					367:372	pKa values	363:372	pKa values	363:372	More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values).
33922254	0	55	theme	Organic	40:46	arg1	Solutions					53:61	Organic Acid Solutions	40:61	Organic Acid Solutions	40:61	The Kinetics of Chitosan Degradation in Organic Acid Solutions.
33922254	4	56	theme	formic	506:511	arg1	acids					513:517	lactic, acetic, malic, and formic acids	479:517	lactic, acetic, malic, and formic acids	479:517	Solutions of lactic, acetic, malic, and formic acids in concentrations of 3% wt.
33922254	1	57	theme	chitosan	107:114	arg1	degradation					116:126	chitosan degradation	107:126	chitosan degradation in organic acid solutions according to their different dissociation characteristics	107:210	This paper presents a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics.
33922254	7	58	theme	h	834:834	arg1	temperature					777:787	a temperature	775:787	a temperature of 20 °C ± 1 °C	775:803	Changes in the viscosity parameters were performed at a temperature of 20 °C ± 1 °C and a timeframe of up to 168 h (7 days).
33922254	7	58	theme	h	834:834	arg1	timeframe					811:819	a timeframe	809:819	a timeframe of up to 168 h (7 days)	809:843	Changes in the viscosity parameters were performed at a temperature of 20 °C ± 1 °C and a timeframe of up to 168 h (7 days).
33922254	9	59	theme	other	1112:1116	arg1	types					1118:1122	other types	1112:1122	other types of processing	1112:1136	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	10	60	theme	effective	1314:1322	arg1	process					1344:1350	an effective and stable spinning process	1311:1350	an effective and stable spinning process	1311:1350	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	9	61	theme	electrospinning	1033:1047	arg1	purpose					1022:1028	the purpose	1018:1028	the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing	1018:1136	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	1	62	from	study	98:102	arg1	degradation					116:126	chitosan degradation	107:126	chitosan degradation in organic acid solutions according to their different dissociation characteristics	107:210	This paper presents a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics.
33922254	7	63	from	Changes	721:727	arg1	parameters					746:755	the viscosity parameters	732:755	the viscosity parameters	732:755	Changes in the viscosity parameters were performed at a temperature of 20 °C ± 1 °C and a timeframe of up to 168 h (7 days).
33922254	8	64	theme	chemical	850:857	arg1	structure					859:867	chemical structure	850:867	chemical structure	850:867	The chemical structure and DDA of the initial chitosan were analyzed using 1H-NMR spectroscopy analysis.
33922254	9	65	theme	high	998:1001	arg1	importance					1003:1012	high importance	998:1012	high importance	998:1012	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	6	66	theme	degradation	591:601	arg1	progress					579:586	The progress	575:586	The progress of degradation	575:601	The progress of degradation was determined based on the intrinsic viscosity measurement, GPC/SEC chromatographic analysis, and their correlation.
33922254	10	67	theme	dissociation	1174:1185	arg1	constant					1187:1194	the dissociation constant	1170:1194	the dissociation constant of the solvent	1170:1209	Understanding the influence of the dissociation constant of the solvent on the kinetics of chitosan degradation will allow the selection of an appropriate medium, ensuring an effective and stable spinning process, in which the occurrence of polymer degradation is unfavorable.
33922254	2	68	theme	study	244:248	arg1	aim					233:235	the aim	229:235	the aim of the study	229:248	More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values).
33922254	9	69	theme	production	1050:1059	arg1	purpose					1022:1028	the purpose	1018:1028	the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing	1018:1136	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
33922254	2	70	theme	pKa	363:365	arg1	constants					352:360	the different acid dissociation constants	320:360	the different acid dissociation constants (pKa values)	320:373	More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values).
33922254	2	70	theme	pKa	363:365	arg1	values					367:372	pKa values	363:372	pKa values	363:372	More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values).
33922254	2	71	from	kinetics	271:278	arg1	constants					352:360	the different acid dissociation constants	320:360	the different acid dissociation constants (pKa values)	320:373	More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values).
33922254	2	71	from	kinetics	271:278	arg1	values					367:372	pKa values	363:372	pKa values	363:372	More precisely, the aim of the study was to determine the kinetics of the degradation process depending on the different acid dissociation constants (pKa values).
33922254	1	72	theme	acid	139:142	arg1	solutions					144:152	organic acid solutions	131:152	organic acid solutions according to their different dissociation characteristics	131:210	This paper presents a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics.
33922254	9	73	theme	study	971:975	arg1	results					955:961	The results	951:961	The results of this study	951:975	The results of this study can be considered of high importance for the purpose of electrospinning, production of micro- and nano-capsules for drug delivery, and other types of processing.
32419444	5	0	from	blue	850:853	arg1	change					838:843	a macroscopic color change	818:843	a macroscopic color change from blue to yellow	818:863	The color of the film could be regulated repeatedly under the stimulus of cyclohexanone with an obvious red shift up to 107 nm, corresponding to a macroscopic color change from blue to yellow.
32419444	7	1	theme	bionics	1103:1109	arg1	principle					1111:1119	the bionics principle	1099:1119	the bionics principle	1099:1119	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	1	2	theme	natural	169:175	arg1	world					177:181	the natural world	165:181	the natural world	165:181	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	4	3	theme	reflectance	655:665	arg1	peak					667:670	the reflectance peak	651:670	the reflectance peak	651:670	PEG-PPG-PEG triblock copolymers (PPPTCs) were blended with CNCs, giving rise to the organic-solvent-responsive structural color and wider red-shift window of the reflectance peak.
32419444	5	4	theme	macroscopic	820:830	arg1	change					838:843	a macroscopic color change	818:843	a macroscopic color change from blue to yellow	818:863	The color of the film could be regulated repeatedly under the stimulus of cyclohexanone with an obvious red shift up to 107 nm, corresponding to a macroscopic color change from blue to yellow.
32419444	6	5	theme	one-step	971:978	arg1	method					980:985	a one-step method	969:985	a one-step method to introduce hydrophobicity, successfully preventing the effect of water on the ordered nanostructure	969:1087	Low-surface-energy compound hexadecyltrimethoxysilane (HDTMS) was covalently grafted on the surface in a one-step method to introduce hydrophobicity, successfully preventing the effect of water on the ordered nanostructure.
32419444	6	6	theme	Low-surface-energy	866:883	arg1	HDTMS					921:925	HDTMS	921:925	HDTMS	921:925	Low-surface-energy compound hexadecyltrimethoxysilane (HDTMS) was covalently grafted on the surface in a one-step method to introduce hydrophobicity, successfully preventing the effect of water on the ordered nanostructure.
32419444	6	6	theme	Low-surface-energy	866:883	arg1	hexadecyltrimethoxysilane					894:918	Low-surface-energy compound hexadecyltrimethoxysilane	866:918	Low-surface-energy compound hexadecyltrimethoxysilane (HDTMS)	866:926	Low-surface-energy compound hexadecyltrimethoxysilane (HDTMS) was covalently grafted on the surface in a one-step method to introduce hydrophobicity, successfully preventing the effect of water on the ordered nanostructure.
32419444	7	7	theme	CNC/PPPTC	1138:1146	arg1	films					1162:1166	the as-prepared CNC/PPPTC nanocomposite films	1122:1166	the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity	1122:1217	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	7	theme	CNC/PPPTC	1138:1146	arg1	beneficial					1223:1232	beneficial	1223:1232	beneficial	1223:1232	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	8	theme	hydrophobic	1299:1309	arg1	paper					1337:1341	rewritable hydrophobic structural-color-changing paper	1288:1341	rewritable hydrophobic structural-color-changing paper	1288:1341	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	8	theme	hydrophobic	1299:1309	arg1	screens					1279:1285	display screens	1271:1285	display screens	1271:1285	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	3	9	with	color	460:464	arg1	helicity					483:490	left-handed helicity	471:490	left-handed helicity	471:490	Cellulose nanocrystals (CNCs) provided structural color with left-handed helicity.
32419444	7	10	theme	rewritable	1288:1297	arg1	paper					1337:1341	rewritable hydrophobic structural-color-changing paper	1288:1341	rewritable hydrophobic structural-color-changing paper	1288:1341	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	10	theme	rewritable	1288:1297	arg1	screens					1279:1285	display screens	1271:1285	display screens	1271:1285	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	11	from	applications	1255:1266	arg1	sensors					1355:1361	biomimetic sensors	1344:1361	biomimetic sensors	1344:1361	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	11	from	applications	1255:1266	arg1	paper					1337:1341	rewritable hydrophobic structural-color-changing paper	1288:1341	rewritable hydrophobic structural-color-changing paper	1288:1341	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	11	from	applications	1255:1266	arg1	screens					1279:1285	display screens	1271:1285	display screens	1271:1285	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	6	12	theme	water	1054:1058	arg1	effect					1044:1049	the effect	1040:1049	the effect of water on the ordered nanostructure	1040:1087	Low-surface-energy compound hexadecyltrimethoxysilane (HDTMS) was covalently grafted on the surface in a one-step method to introduce hydrophobicity, successfully preventing the effect of water on the ordered nanostructure.
32419444	2	13	theme	structural-color	309:324	arg1	film					326:329	a novel bioinspired variable structural-color film	280:329	a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity	280:392	Herein, a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity was fabricated.
32419444	2	14	theme	surface	371:377	arg1	hydrophobicity					379:392	surface hydrophobicity	371:392	surface hydrophobicity	371:392	Herein, a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity was fabricated.
32419444	7	15	with	films	1162:1166	arg1	hydrophobicity					1204:1217	hydrophobicity	1204:1217	hydrophobicity	1204:1217	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	15	with	films	1162:1166	arg1	colors					1193:1198	variable structural colors	1173:1198	variable structural colors	1173:1198	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	5	16	theme	film	690:693	arg1	color					677:681	The color	673:681	The color of the film	673:693	The color of the film could be regulated repeatedly under the stimulus of cyclohexanone with an obvious red shift up to 107 nm, corresponding to a macroscopic color change from blue to yellow.
32419444	4	17	theme	peak	667:670	arg1	color					615:619	the organic-solvent-responsive structural color	573:619	the organic-solvent-responsive structural color	573:619	PEG-PPG-PEG triblock copolymers (PPPTCs) were blended with CNCs, giving rise to the organic-solvent-responsive structural color and wider red-shift window of the reflectance peak.
32419444	4	17	theme	peak	667:670	arg1	window					641:646	wider red-shift window	625:646	wider red-shift window	625:646	PEG-PPG-PEG triblock copolymers (PPPTCs) were blended with CNCs, giving rise to the organic-solvent-responsive structural color and wider red-shift window of the reflectance peak.
32419444	2	18	theme	variable	300:307	arg1	film					326:329	a novel bioinspired variable structural-color film	280:329	a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity	280:392	Herein, a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity was fabricated.
32419444	3	19	theme	Cellulose	410:418	arg1	CNCs					434:437	CNCs	434:437	CNCs	434:437	Cellulose nanocrystals (CNCs) provided structural color with left-handed helicity.
32419444	3	19	theme	Cellulose	410:418	arg1	nanocrystals					420:431	Cellulose nanocrystals	410:431	Cellulose nanocrystals (CNCs)	410:438	Cellulose nanocrystals (CNCs) provided structural color with left-handed helicity.
32419444	5	20	theme	color	832:836	arg1	change					838:843	a macroscopic color change	818:843	a macroscopic color change from blue to yellow	818:863	The color of the film could be regulated repeatedly under the stimulus of cyclohexanone with an obvious red shift up to 107 nm, corresponding to a macroscopic color change from blue to yellow.
32419444	7	21	theme	nanocomposite	1148:1160	arg1	films					1162:1166	the as-prepared CNC/PPPTC nanocomposite films	1122:1166	the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity	1122:1217	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	21	theme	nanocomposite	1148:1160	arg1	beneficial					1223:1232	beneficial	1223:1232	beneficial	1223:1232	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	2	22	theme	bioinspired	288:298	arg1	film					326:329	a novel bioinspired variable structural-color film	280:329	a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity	280:392	Herein, a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity was fabricated.
32419444	1	23	theme	stunning	191:198	arg1	colors					218:223	stunning unique structural colors	191:223	stunning unique structural colors as well as excellent hydrophobic performances	191:269	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	0	24	theme	Hydrophobic	12:22	arg1	Papers					120:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	0	24	theme	Hydrophobic	12:22	arg1	Films					56:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	5	25	dep	shift	781:785	arg1	nm					797:798	nm	797:798	nm	797:798	The color of the film could be regulated repeatedly under the stimulus of cyclohexanone with an obvious red shift up to 107 nm, corresponding to a macroscopic color change from blue to yellow.
32419444	1	26	theme	unique	200:205	arg1	colors					218:223	stunning unique structural colors	191:223	stunning unique structural colors as well as excellent hydrophobic performances	191:269	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	3	27	theme	structural	449:458	arg1	color					460:464	structural color	449:464	structural color with left-handed helicity	449:490	Cellulose nanocrystals (CNCs) provided structural color with left-handed helicity.
32419444	4	28	theme	red-shift	631:639	arg1	window					641:646	wider red-shift window	625:646	wider red-shift window	625:646	PEG-PPG-PEG triblock copolymers (PPPTCs) were blended with CNCs, giving rise to the organic-solvent-responsive structural color and wider red-shift window of the reflectance peak.
32419444	6	29	theme	compound	885:892	arg1	HDTMS					921:925	HDTMS	921:925	HDTMS	921:925	Low-surface-energy compound hexadecyltrimethoxysilane (HDTMS) was covalently grafted on the surface in a one-step method to introduce hydrophobicity, successfully preventing the effect of water on the ordered nanostructure.
32419444	6	29	theme	compound	885:892	arg1	hexadecyltrimethoxysilane					894:918	Low-surface-energy compound hexadecyltrimethoxysilane	866:918	Low-surface-energy compound hexadecyltrimethoxysilane (HDTMS)	866:926	Low-surface-energy compound hexadecyltrimethoxysilane (HDTMS) was covalently grafted on the surface in a one-step method to introduce hydrophobicity, successfully preventing the effect of water on the ordered nanostructure.
32419444	7	30	theme	variable	1173:1180	arg1	colors					1193:1198	variable structural colors	1173:1198	variable structural colors	1173:1198	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	6	31	theme	ordered	1067:1073	arg1	nanostructure					1075:1087	the ordered nanostructure	1063:1087	the ordered nanostructure	1063:1087	Low-surface-energy compound hexadecyltrimethoxysilane (HDTMS) was covalently grafted on the surface in a one-step method to introduce hydrophobicity, successfully preventing the effect of water on the ordered nanostructure.
32419444	1	32	theme	structural	207:216	arg1	colors					218:223	stunning unique structural colors	191:223	stunning unique structural colors as well as excellent hydrophobic performances	191:269	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	0	33	theme	Nanocrystal	34:44	arg1	Papers					120:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	0	33	theme	Nanocrystal	34:44	arg1	Films					56:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	4	34	theme	wider	625:629	arg1	window					641:646	wider red-shift window	625:646	wider red-shift window	625:646	PEG-PPG-PEG triblock copolymers (PPPTCs) were blended with CNCs, giving rise to the organic-solvent-responsive structural color and wider red-shift window of the reflectance peak.
32419444	5	35	theme	obvious	769:775	arg1	shift					781:785	an obvious red shift	766:785	an obvious red shift up to 107 nm	766:798	The color of the film could be regulated repeatedly under the stimulus of cyclohexanone with an obvious red shift up to 107 nm, corresponding to a macroscopic color change from blue to yellow.
32419444	1	36	theme	beetles	136:142	arg1	moths					145:149	moths	145:149	moths	145:149	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	1	36	theme	beetles	136:142	arg1	birds					156:160	birds	156:160	birds	156:160	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	1	36	theme	beetles	136:142	arg1	beetles					136:142	beetles	136:142	beetles	136:142	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	1	36	theme	beetles	136:142	arg1	Lots					128:131	Lots	128:131	Lots of beetles, moths, and birds in the natural world	128:181	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	7	37	theme	structural	1182:1191	arg1	colors					1193:1198	variable structural colors	1173:1198	variable structural colors	1173:1198	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	0	38	theme	Cellulose	24:32	arg1	Papers					120:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	0	38	theme	Cellulose	24:32	arg1	Films					56:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	5	39	theme	red	777:779	arg1	shift					781:785	an obvious red shift	766:785	an obvious red shift up to 107 nm	766:798	The color of the film could be regulated repeatedly under the stimulus of cyclohexanone with an obvious red shift up to 107 nm, corresponding to a macroscopic color change from blue to yellow.
32419444	7	40	theme	prospective	1243:1253	arg1	applications					1255:1266	their prospective applications	1237:1266	their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth	1237:1375	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	3	41	theme	left-handed	471:481	arg1	helicity					483:490	left-handed helicity	471:490	left-handed helicity	471:490	Cellulose nanocrystals (CNCs) provided structural color with left-handed helicity.
32419444	5	42	with	cyclohexanone	747:759	arg1	shift					781:785	an obvious red shift	766:785	an obvious red shift up to 107 nm	766:798	The color of the film could be regulated repeatedly under the stimulus of cyclohexanone with an obvious red shift up to 107 nm, corresponding to a macroscopic color change from blue to yellow.
32419444	0	43	theme	Composite	46:54	arg1	Papers					120:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	0	43	theme	Composite	46:54	arg1	Films					56:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	4	44	theme	structural	604:613	arg1	color					615:619	the organic-solvent-responsive structural color	573:619	the organic-solvent-responsive structural color	573:619	PEG-PPG-PEG triblock copolymers (PPPTCs) were blended with CNCs, giving rise to the organic-solvent-responsive structural color and wider red-shift window of the reflectance peak.
32419444	6	45	from	effect	1044:1049	arg1	nanostructure					1075:1087	the ordered nanostructure	1063:1087	the ordered nanostructure	1063:1087	Low-surface-energy compound hexadecyltrimethoxysilane (HDTMS) was covalently grafted on the surface in a one-step method to introduce hydrophobicity, successfully preventing the effect of water on the ordered nanostructure.
32419444	6	46	from	surface	958:964	arg1	method					980:985	a one-step method	969:985	a one-step method to introduce hydrophobicity, successfully preventing the effect of water on the ordered nanostructure	969:1087	Low-surface-energy compound hexadecyltrimethoxysilane (HDTMS) was covalently grafted on the surface in a one-step method to introduce hydrophobicity, successfully preventing the effect of water on the ordered nanostructure.
32419444	0	47	theme	Organic-Solvent-Responsive	65:90	arg1	Papers					120:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	0	47	theme	Organic-Solvent-Responsive	65:90	arg1	Films					56:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	4	48	theme	organic-solvent-responsive	577:602	arg1	color					615:619	the organic-solvent-responsive structural color	573:619	the organic-solvent-responsive structural color	573:619	PEG-PPG-PEG triblock copolymers (PPPTCs) were blended with CNCs, giving rise to the organic-solvent-responsive structural color and wider red-shift window of the reflectance peak.
32419444	5	49	dep	nm	797:798	arg1	107					793:795	107	793:795	107	793:795	The color of the film could be regulated repeatedly under the stimulus of cyclohexanone with an obvious red shift up to 107 nm, corresponding to a macroscopic color change from blue to yellow.
32419444	1	50	theme	moths	145:149	arg1	moths					145:149	moths	145:149	moths	145:149	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	1	50	theme	moths	145:149	arg1	birds					156:160	birds	156:160	birds	156:160	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	1	50	theme	moths	145:149	arg1	beetles					136:142	beetles	136:142	beetles	136:142	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	1	50	theme	moths	145:149	arg1	Lots					128:131	Lots	128:131	Lots of beetles, moths, and birds in the natural world	128:181	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	7	51	theme	as-prepared	1126:1136	arg1	films					1162:1166	the as-prepared CNC/PPPTC nanocomposite films	1122:1166	the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity	1122:1217	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	51	theme	as-prepared	1126:1136	arg1	beneficial					1223:1232	beneficial	1223:1232	beneficial	1223:1232	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	5	52	theme	cyclohexanone	747:759	arg1	stimulus					735:742	the stimulus	731:742	the stimulus of cyclohexanone with an obvious red shift up to 107 nm	731:798	The color of the film could be regulated repeatedly under the stimulus of cyclohexanone with an obvious red shift up to 107 nm, corresponding to a macroscopic color change from blue to yellow.
32419444	4	53	theme	PEG-PPG-PEG	493:503	arg1	PPPTCs					526:531	PPPTCs	526:531	PPPTCs	526:531	PEG-PPG-PEG triblock copolymers (PPPTCs) were blended with CNCs, giving rise to the organic-solvent-responsive structural color and wider red-shift window of the reflectance peak.
32419444	4	53	theme	PEG-PPG-PEG	493:503	arg1	copolymers					514:523	PEG-PPG-PEG triblock copolymers	493:523	PEG-PPG-PEG triblock copolymers (PPPTCs)	493:532	PEG-PPG-PEG triblock copolymers (PPPTCs) were blended with CNCs, giving rise to the organic-solvent-responsive structural color and wider red-shift window of the reflectance peak.
32419444	5	54	dep	blue	850:853	arg1	yellow					858:863	yellow	858:863	yellow	858:863	The color of the film could be regulated repeatedly under the stimulus of cyclohexanone with an obvious red shift up to 107 nm, corresponding to a macroscopic color change from blue to yellow.
32419444	5	54	dep	blue	850:853	arg1	to					855:856	to	855:856	to	855:856	The color of the film could be regulated repeatedly under the stimulus of cyclohexanone with an obvious red shift up to 107 nm, corresponding to a macroscopic color change from blue to yellow.
32419444	7	55	theme	biomimetic	1344:1353	arg1	screens					1279:1285	display screens	1271:1285	display screens	1271:1285	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	55	theme	biomimetic	1344:1353	arg1	sensors					1355:1361	biomimetic sensors	1344:1361	biomimetic sensors	1344:1361	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	2	56	theme	novel	282:286	arg1	film					326:329	a novel bioinspired variable structural-color film	280:329	a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity	280:392	Herein, a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity was fabricated.
32419444	2	57	theme	organic-solvent	336:350	arg1	responsiveness					352:365	organic-solvent responsiveness	336:365	organic-solvent responsiveness	336:365	Herein, a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity was fabricated.
32419444	1	58	theme	excellent	236:244	arg1	performances					258:269	excellent hydrophobic performances	236:269	stunning unique structural colors as well as excellent hydrophobic performances	191:269	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	5	59	dep	107	793:795	arg1	to					790:791	to	790:791	to	790:791	The color of the film could be regulated repeatedly under the stimulus of cyclohexanone with an obvious red shift up to 107 nm, corresponding to a macroscopic color change from blue to yellow.
32419444	1	60	theme	birds	156:160	arg1	moths					145:149	moths	145:149	moths	145:149	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	1	60	theme	birds	156:160	arg1	birds					156:160	birds	156:160	birds	156:160	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	1	60	theme	birds	156:160	arg1	beetles					136:142	beetles	136:142	beetles	136:142	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	1	60	theme	birds	156:160	arg1	Lots					128:131	Lots	128:131	Lots of beetles, moths, and birds in the natural world	128:181	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	1	61	from	Lots	128:131	arg1	world					177:181	the natural world	165:181	the natural world	165:181	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	1	62	theme	hydrophobic	246:256	arg1	performances					258:269	excellent hydrophobic performances	236:269	stunning unique structural colors as well as excellent hydrophobic performances	191:269	Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances.
32419444	0	63	theme	Rewritable	109:118	arg1	Papers					120:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	0	63	theme	Rewritable	109:118	arg1	Films					56:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	4	64	theme	triblock	505:512	arg1	PPPTCs					526:531	PPPTCs	526:531	PPPTCs	526:531	PEG-PPG-PEG triblock copolymers (PPPTCs) were blended with CNCs, giving rise to the organic-solvent-responsive structural color and wider red-shift window of the reflectance peak.
32419444	4	64	theme	triblock	505:512	arg1	copolymers					514:523	PEG-PPG-PEG triblock copolymers	493:523	PEG-PPG-PEG triblock copolymers (PPPTCs)	493:532	PEG-PPG-PEG triblock copolymers (PPPTCs) were blended with CNCs, giving rise to the organic-solvent-responsive structural color and wider red-shift window of the reflectance peak.
32419444	2	65	with	film	326:329	arg1	responsiveness					352:365	organic-solvent responsiveness	336:365	organic-solvent responsiveness	336:365	Herein, a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity was fabricated.
32419444	2	65	with	film	326:329	arg1	hydrophobicity					379:392	surface hydrophobicity	371:392	surface hydrophobicity	371:392	Herein, a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity was fabricated.
32419444	0	66	theme	Structural-Color	92:107	arg1	Papers					120:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Organic-Solvent-Responsive Structural-Color Rewritable Papers	65:125	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	0	66	theme	Structural-Color	92:107	arg1	Films					56:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Hydrophobic Cellulose Nanocrystal Composite Films	12:60	Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.
32419444	7	67	theme	display	1271:1277	arg1	sensors					1355:1361	biomimetic sensors	1344:1361	biomimetic sensors	1344:1361	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	67	theme	display	1271:1277	arg1	paper					1337:1341	rewritable hydrophobic structural-color-changing paper	1288:1341	rewritable hydrophobic structural-color-changing paper	1288:1341	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	67	theme	display	1271:1277	arg1	screens					1279:1285	display screens	1271:1285	display screens	1271:1285	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	68	theme	structural-color-changing	1311:1335	arg1	paper					1337:1341	rewritable hydrophobic structural-color-changing paper	1288:1341	rewritable hydrophobic structural-color-changing paper	1288:1341	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
32419444	7	68	theme	structural-color-changing	1311:1335	arg1	screens					1279:1285	display screens	1271:1285	display screens	1271:1285	Based on the bionics principle, the as-prepared CNC/PPPTC nanocomposite films with variable structural colors and hydrophobicity are beneficial to their prospective applications in display screens, rewritable hydrophobic structural-color-changing paper, biomimetic sensors, and so forth.
34407490	0	0	theme	amaranth	77:84	arg1	flour					86:90	amaranth flour	77:90	amaranth flour	77:90	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.
34407490	8	1	theme	amaranth	981:988	arg1	aroma					990:994	amaranth aroma	981:994	amaranth aroma	981:994	Quinoa and corn-starch sausages were compared and amaranth aroma was disliked.
34407490	9	2	theme	sausage	1099:1105	arg1	production					1107:1116	sausage production	1099:1116	sausage production	1099:1116	As such, it was concluded that quinoa and amaranth can be used as alternative binders in sausage production.
34407490	2	3	theme	alternative	313:323	arg1	binders					325:331	alternative binders	313:331	alternative binders to corn-starch	313:346	Amaranth and quinoa flours were evaluated for use as alternative binders to corn-starch.
34407490	1	4	from	increase	143:150	arg1	demand					155:160	demand	155:160	demand for sausages in developing countries	155:197	There is an increase in demand for sausages in developing countries, however, accessibility and cost of binders are a challenge.
34407490	2	5	theme	Amaranth	260:267	arg1	flours					280:285	Amaranth and quinoa flours	260:285	Amaranth and quinoa flours	260:285	Amaranth and quinoa flours were evaluated for use as alternative binders to corn-starch.
34407490	7	6	theme	emulsion	829:836	arg1	stability					838:846	emulsion stability	829:846	emulsion stability	829:846	There were also significantly different on functional properties except emulsion stability and pH. Thermal properties of flours also had a significant difference (p < 0.05).
34407490	1	7	theme	binders	235:241	arg1	accessibility					209:221	accessibility	209:221	accessibility	209:221	There is an increase in demand for sausages in developing countries, however, accessibility and cost of binders are a challenge.
34407490	1	7	theme	binders	235:241	arg1	challenge					249:257	a challenge	247:257	a challenge	247:257	There is an increase in demand for sausages in developing countries, however, accessibility and cost of binders are a challenge.
34407490	1	7	theme	binders	235:241	arg1	cost					227:230	cost	227:230	cost	227:230	There is an increase in demand for sausages in developing countries, however, accessibility and cost of binders are a challenge.
34407490	0	8	theme	flour	86:90	arg1	properties					52:61	Proximate, physico-chemical, functional and sensory properties	0:61	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.	0:129	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.
34407490	5	9	theme	9-point	625:631	arg1	scale					641:645	a 9-point hedonic scale	623:645	a 9-point hedonic scale	623:645	To determine acceptability, sensory evaluation was carried out using a 9-point hedonic scale.
34407490	6	10	theme	fat	744:746	arg1	content					748:754	fat content	744:754	fat content	744:754	Flours showed a significant difference (p < 0.05) on protein, carbohydrates, moisture, ash, and fat content.
34407490	7	11	theme	functional	800:809	arg1	properties					811:820	functional properties	800:820	functional properties	800:820	There were also significantly different on functional properties except emulsion stability and pH. Thermal properties of flours also had a significant difference (p < 0.05).
34407490	5	12	theme	sensory	582:588	arg1	evaluation					590:599	sensory evaluation	582:599	sensory evaluation	582:599	To determine acceptability, sensory evaluation was carried out using a 9-point hedonic scale.
34407490	8	13	theme	Quinoa	931:936	arg1	sausages					954:961	Quinoa and corn-starch sausages	931:961	Quinoa and corn-starch sausages	931:961	Quinoa and corn-starch sausages were compared and amaranth aroma was disliked.
34407490	6	14	theme	significant	664:674	arg1	p < 0.05					688:695	p < 0.05	688:695	p < 0.05	688:695	Flours showed a significant difference (p < 0.05) on protein, carbohydrates, moisture, ash, and fat content.
34407490	6	14	theme	significant	664:674	arg1	difference					676:685	a significant difference	662:685	a significant difference (p < 0.05)	662:696	Flours showed a significant difference (p < 0.05) on protein, carbohydrates, moisture, ash, and fat content.
34407490	3	15	theme	flours	413:418	arg1	composition					359:369	Proximate composition	349:369	Proximate composition	349:369	Proximate composition, functional and thermal properties of the flours were determined.
34407490	3	15	theme	flours	413:418	arg1	properties					395:404	thermal properties	387:404	thermal properties	387:404	Proximate composition, functional and thermal properties of the flours were determined.
34407490	0	16	theme	potential	95:103	arg1	binders					105:111	potential binders	95:111	potential binders in beef sausages	95:128	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.
34407490	7	17	theme	significant	896:906	arg1	difference					908:917	a significant difference	894:917	a significant difference (p < 0.05)	894:928	There were also significantly different on functional properties except emulsion stability and pH. Thermal properties of flours also had a significant difference (p < 0.05).
34407490	7	17	theme	significant	896:906	arg1	p < 0.05					920:927	p < 0.05	920:927	p < 0.05	920:927	There were also significantly different on functional properties except emulsion stability and pH. Thermal properties of flours also had a significant difference (p < 0.05).
34407490	8	18	theme	corn-starch	942:952	arg1	sausages					954:961	Quinoa and corn-starch sausages	931:961	Quinoa and corn-starch sausages	931:961	Quinoa and corn-starch sausages were compared and amaranth aroma was disliked.
34407490	0	19	theme	Proximate	0:8	arg1	properties					52:61	Proximate, physico-chemical, functional and sensory properties	0:61	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.	0:129	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.
34407490	7	20	theme	flours	878:883	arg1	stability					838:846	emulsion stability	829:846	emulsion stability	829:846	There were also significantly different on functional properties except emulsion stability and pH. Thermal properties of flours also had a significant difference (p < 0.05).
34407490	7	20	theme	flours	878:883	arg1	properties					864:873	pH. Thermal properties	852:873	pH. Thermal properties	852:873	There were also significantly different on functional properties except emulsion stability and pH. Thermal properties of flours also had a significant difference (p < 0.05).
34407490	9	21	from	binders	1088:1094	arg1	production					1107:1116	sausage production	1099:1116	sausage production	1099:1116	As such, it was concluded that quinoa and amaranth can be used as alternative binders in sausage production.
34407490	0	22	theme	beef	116:119	arg1	sausages					121:128	beef sausages	116:128	beef sausages	116:128	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.
34407490	2	23	theme	quinoa	273:278	arg1	flours					280:285	Amaranth and quinoa flours	260:285	Amaranth and quinoa flours	260:285	Amaranth and quinoa flours were evaluated for use as alternative binders to corn-starch.
34407490	3	24	theme	Proximate	349:357	arg1	composition					359:369	Proximate composition	349:369	Proximate composition	349:369	Proximate composition, functional and thermal properties of the flours were determined.
34407490	1	25	theme	developing	178:187	arg1	countries					189:197	developing countries	178:197	developing countries	178:197	There is an increase in demand for sausages in developing countries, however, accessibility and cost of binders are a challenge.
34407490	3	26	theme	thermal	387:393	arg1	properties					395:404	thermal properties	387:404	thermal properties	387:404	Proximate composition, functional and thermal properties of the flours were determined.
34407490	0	27	theme	functional	29:38	arg1	properties					52:61	Proximate, physico-chemical, functional and sensory properties	0:61	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.	0:129	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.
34407490	4	28	theme	sausages	492:499	arg1	WHC					461:463	WHC	461:463	WHC	461:463	Water holding capacity (WHC) and cooking losses of the sausages made with the flours as binders were also evaluated.
34407490	4	28	theme	sausages	492:499	arg1	capacity					451:458	Water holding capacity	437:458	Water holding capacity (WHC)	437:464	Water holding capacity (WHC) and cooking losses of the sausages made with the flours as binders were also evaluated.
34407490	4	28	theme	sausages	492:499	arg1	losses					478:483	cooking losses	470:483	cooking losses of the sausages made with the flours as binders	470:531	Water holding capacity (WHC) and cooking losses of the sausages made with the flours as binders were also evaluated.
34407490	4	29	theme	holding	443:449	arg1	WHC					461:463	WHC	461:463	WHC	461:463	Water holding capacity (WHC) and cooking losses of the sausages made with the flours as binders were also evaluated.
34407490	4	29	theme	holding	443:449	arg1	capacity					451:458	Water holding capacity	437:458	Water holding capacity (WHC)	437:464	Water holding capacity (WHC) and cooking losses of the sausages made with the flours as binders were also evaluated.
34407490	5	30	theme	hedonic	633:639	arg1	scale					641:645	a 9-point hedonic scale	623:645	a 9-point hedonic scale	623:645	To determine acceptability, sensory evaluation was carried out using a 9-point hedonic scale.
34407490	4	31	theme	Water	437:441	arg1	WHC					461:463	WHC	461:463	WHC	461:463	Water holding capacity (WHC) and cooking losses of the sausages made with the flours as binders were also evaluated.
34407490	4	31	theme	Water	437:441	arg1	capacity					451:458	Water holding capacity	437:458	Water holding capacity (WHC)	437:464	Water holding capacity (WHC) and cooking losses of the sausages made with the flours as binders were also evaluated.
34407490	7	32	contain	had	890:892	arg1	stability					838:846	emulsion stability	829:846	emulsion stability	829:846	There were also significantly different on functional properties except emulsion stability and pH. Thermal properties of flours also had a significant difference (p < 0.05).
34407490	7	32	contain	had	890:892	arg2	p < 0.05					920:927	p < 0.05	920:927	p < 0.05	920:927	There were also significantly different on functional properties except emulsion stability and pH. Thermal properties of flours also had a significant difference (p < 0.05).
34407490	7	32	contain	had	890:892	arg2	difference					908:917	a significant difference	894:917	a significant difference (p < 0.05)	894:928	There were also significantly different on functional properties except emulsion stability and pH. Thermal properties of flours also had a significant difference (p < 0.05).
34407490	7	32	contain	had	890:892	arg1	properties					864:873	pH. Thermal properties	852:873	pH. Thermal properties	852:873	There were also significantly different on functional properties except emulsion stability and pH. Thermal properties of flours also had a significant difference (p < 0.05).
34407490	0	33	theme	sensory	44:50	arg1	properties					52:61	Proximate, physico-chemical, functional and sensory properties	0:61	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.	0:129	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.
34407490	0	34	from	binders	105:111	arg1	sausages					121:128	beef sausages	116:128	beef sausages	116:128	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.
34407490	9	35	used	used	1068:1071	arg2	amaranth					1052:1059	amaranth	1052:1059	amaranth	1052:1059	As such, it was concluded that quinoa and amaranth can be used as alternative binders in sausage production.
34407490	9	35	used	used	1068:1071	arg2	quinoa					1041:1046	quinoa	1041:1046	quinoa	1041:1046	As such, it was concluded that quinoa and amaranth can be used as alternative binders in sausage production.
34407490	9	35	used	used	1068:1071	arg2	binders					1088:1094	alternative binders	1076:1094	alternative binders in sausage production	1076:1116	As such, it was concluded that quinoa and amaranth can be used as alternative binders in sausage production.
34407490	9	36	theme	alternative	1076:1086	arg1	binders					1088:1094	alternative binders	1076:1094	alternative binders in sausage production	1076:1116	As such, it was concluded that quinoa and amaranth can be used as alternative binders in sausage production.
34407490	9	36	theme	alternative	1076:1086	arg1	amaranth					1052:1059	amaranth	1052:1059	amaranth	1052:1059	As such, it was concluded that quinoa and amaranth can be used as alternative binders in sausage production.
34407490	9	36	theme	alternative	1076:1086	arg1	quinoa					1041:1046	quinoa	1041:1046	quinoa	1041:1046	As such, it was concluded that quinoa and amaranth can be used as alternative binders in sausage production.
34407490	7	37	theme	pH.	852:854	arg1	properties					864:873	pH. Thermal properties	852:873	pH. Thermal properties	852:873	There were also significantly different on functional properties except emulsion stability and pH. Thermal properties of flours also had a significant difference (p < 0.05).
34407490	0	38	theme	quinoa	66:71	arg1	properties					52:61	Proximate, physico-chemical, functional and sensory properties	0:61	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.	0:129	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.
34407490	1	39	from	sausages	166:173	arg1	countries					189:197	developing countries	178:197	developing countries	178:197	There is an increase in demand for sausages in developing countries, however, accessibility and cost of binders are a challenge.
34407490	7	40	theme	Thermal	856:862	arg1	properties					864:873	pH. Thermal properties	852:873	pH. Thermal properties	852:873	There were also significantly different on functional properties except emulsion stability and pH. Thermal properties of flours also had a significant difference (p < 0.05).
34407490	4	41	theme	cooking	470:476	arg1	losses					478:483	cooking losses	470:483	cooking losses of the sausages made with the flours as binders	470:531	Water holding capacity (WHC) and cooking losses of the sausages made with the flours as binders were also evaluated.
34407490	0	42	theme	physico-chemical	11:26	arg1	properties					52:61	Proximate, physico-chemical, functional and sensory properties	0:61	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.	0:129	Proximate, physico-chemical, functional and sensory properties OF quinoa and amaranth flour AS potential binders in beef sausages.
33666608	2	0	theme	mechanical	494:503	arg1	properties					505:514	the resulting mechanical properties	480:514	the resulting mechanical properties of hydrogels	480:527	However, commonly, only the mechanical properties of the bioinks or matrix materials are assessed, while the detailed influence of cells on the resulting mechanical properties of hydrogels remains insufficiently understood.
33666608	5	1	theme	soft	1067:1070	arg1	materials					1082:1090	soft composite materials	1067:1090	soft composite materials	1067:1090	Through material modeling, we quantify parameters that describe the highly nonlinear mechanical response of soft composite materials.
33666608	2	2	theme	mechanical	368:377	arg1	properties					379:388	only the mechanical properties	359:388	only the mechanical properties of the bioinks or matrix materials	359:423	However, commonly, only the mechanical properties of the bioinks or matrix materials are assessed, while the detailed influence of cells on the resulting mechanical properties of hydrogels remains insufficiently understood.
33666608	1	3	theme	cell	266:269	arg1	differentiation					271:285	cell differentiation	266:285	cell differentiation	266:285	3D-printing technologies, such as biofabrication, capitalize on the homogeneous distribution and growth of cells inside biomaterial hydrogels, ultimately aiming to allow for cell differentiation, matrix remodeling, and functional tissue analogues.
33666608	2	4	theme	resulting	484:492	arg1	properties					505:514	the resulting mechanical properties	480:514	the resulting mechanical properties of hydrogels	480:527	However, commonly, only the mechanical properties of the bioinks or matrix materials are assessed, while the detailed influence of cells on the resulting mechanical properties of hydrogels remains insufficiently understood.
33666608	2	5	from	influence	458:466	arg1	properties					505:514	the resulting mechanical properties	480:514	the resulting mechanical properties of hydrogels	480:527	However, commonly, only the mechanical properties of the bioinks or matrix materials are assessed, while the detailed influence of cells on the resulting mechanical properties of hydrogels remains insufficiently understood.
33666608	5	6	theme	material	967:974	arg1	modeling					976:983	material modeling	967:983	material modeling	967:983	Through material modeling, we quantify parameters that describe the highly nonlinear mechanical response of soft composite materials.
33666608	3	7	theme	multi-modal	672:682	arg1	analyses					703:710	multi-modal complex mechanical analyses	672:710	multi-modal complex mechanical analyses in the small- and large-strain regimes	672:749	Here, we investigate the properties of hydrogels containing cells and spherical PAAm microgel beads through multi-modal complex mechanical analyses in the small- and large-strain regimes.
33666608	8	8	theme	hydrogel	1477:1484	arg1	mechanics					1486:1494	the final hydrogel mechanics	1467:1494	the final hydrogel mechanics	1467:1494	Our findings highlight cell concentration as a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering.
33666608	7	9	theme	mio	1288:1290	arg1	ml-1					1292:1295	≥6 mio ml-1	1285:1295	≥6 mio ml-1	1285:1295	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	7	9	theme	mio	1288:1290	arg1	concentrations					1269:1282	high cell concentrations	1259:1282	high cell concentrations (≥6 mio ml-1)	1259:1296	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	3	10	theme	large-strain	730:741	arg1	regimes					743:749	the small- and large-strain regimes	715:749	the small- and large-strain regimes	715:749	Here, we investigate the properties of hydrogels containing cells and spherical PAAm microgel beads through multi-modal complex mechanical analyses in the small- and large-strain regimes.
33666608	4	11	theme	mechanical	903:912	arg1	behavior					914:921	the overall mechanical behavior	891:921	the overall mechanical behavior in compression, tension, and shear	891:956	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	5	12	theme	nonlinear	1034:1042	arg1	response					1055:1062	the highly nonlinear mechanical response	1023:1062	the highly nonlinear mechanical response of soft composite materials	1023:1090	Through material modeling, we quantify parameters that describe the highly nonlinear mechanical response of soft composite materials.
33666608	5	13	theme	composite	1072:1080	arg1	materials					1082:1090	soft composite materials	1067:1090	soft composite materials	1067:1090	Through material modeling, we quantify parameters that describe the highly nonlinear mechanical response of soft composite materials.
33666608	7	14	theme	≥6	1285:1286	arg1	ml-1					1292:1295	≥6 mio ml-1	1285:1295	≥6 mio ml-1	1285:1295	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	7	14	theme	≥6	1285:1286	arg1	concentrations					1269:1282	high cell concentrations	1259:1282	high cell concentrations (≥6 mio ml-1)	1259:1296	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	4	15	theme	concentrations	813:826	arg1	contributions					779:791	the individual contributions	764:791	the individual contributions of different filler concentrations	764:826	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	4	15	theme	concentrations	813:826	arg1	matrix					881:886	a non-fibrous oxidized alginate-gelatin hydrogel matrix	832:886	a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear	832:956	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	0	16	theme	Mechanical	0:9	arg1	properties					11:20	Mechanical properties	0:20	Mechanical properties of cell- and microgel	0:42	Mechanical properties of cell- and microgel bead-laden oxidized alginate-gelatin hydrogels.
33666608	1	17	theme	matrix	288:293	arg1	remodeling					295:304	matrix remodeling	288:304	matrix remodeling	288:304	3D-printing technologies, such as biofabrication, capitalize on the homogeneous distribution and growth of cells inside biomaterial hydrogels, ultimately aiming to allow for cell differentiation, matrix remodeling, and functional tissue analogues.
33666608	8	18	with	mechanics	1486:1494	arg1	implications					1502:1513	implications	1502:1513	implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering	1502:1600	Our findings highlight cell concentration as a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering.
33666608	6	19	theme	bead	1163:1166	arg1	concentrations					1168:1181	cell- and bead concentrations	1153:1181	cell- and bead concentrations exceeding four million per milliliter hydrogel	1153:1228	Our results show that the stiffness significantly drops for cell- and bead concentrations exceeding four million per milliliter hydrogel.
33666608	4	20	theme	non-fibrous	834:844	arg1	matrix					881:886	a non-fibrous oxidized alginate-gelatin hydrogel matrix	832:886	a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear	832:956	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	1	21	theme	cells	199:203	arg1	growth					189:194	growth	189:194	growth	189:194	3D-printing technologies, such as biofabrication, capitalize on the homogeneous distribution and growth of cells inside biomaterial hydrogels, ultimately aiming to allow for cell differentiation, matrix remodeling, and functional tissue analogues.
33666608	1	21	theme	cells	199:203	arg1	distribution					172:183	homogeneous distribution	160:183	homogeneous distribution	160:183	3D-printing technologies, such as biofabrication, capitalize on the homogeneous distribution and growth of cells inside biomaterial hydrogels, ultimately aiming to allow for cell differentiation, matrix remodeling, and functional tissue analogues.
33666608	2	22	theme	matrix	408:413	arg1	materials					415:423	the bioinks or matrix materials	393:423	materials	415:423	However, commonly, only the mechanical properties of the bioinks or matrix materials are assessed, while the detailed influence of cells on the resulting mechanical properties of hydrogels remains insufficiently understood.
33666608	2	23	theme	hydrogels	519:527	arg1	properties					505:514	the resulting mechanical properties	480:514	the resulting mechanical properties of hydrogels	480:527	However, commonly, only the mechanical properties of the bioinks or matrix materials are assessed, while the detailed influence of cells on the resulting mechanical properties of hydrogels remains insufficiently understood.
33666608	3	24	contain	containing	613:622	arg1	hydrogels					603:611	hydrogels	603:611	hydrogels containing cells	603:628	Here, we investigate the properties of hydrogels containing cells and spherical PAAm microgel beads through multi-modal complex mechanical analyses in the small- and large-strain regimes.
33666608	3	24	contain	containing	613:622	arg2	cells					624:628	cells	624:628	cells	624:628	Here, we investigate the properties of hydrogels containing cells and spherical PAAm microgel beads through multi-modal complex mechanical analyses in the small- and large-strain regimes.
33666608	1	25	theme	3D-printing	92:102	arg1	biofabrication					126:139	biofabrication	126:139	biofabrication	126:139	3D-printing technologies, such as biofabrication, capitalize on the homogeneous distribution and growth of cells inside biomaterial hydrogels, ultimately aiming to allow for cell differentiation, matrix remodeling, and functional tissue analogues.
33666608	1	25	theme	3D-printing	92:102	arg1	technologies					104:115	3D-printing technologies	92:115	3D-printing technologies	92:115	3D-printing technologies, such as biofabrication, capitalize on the homogeneous distribution and growth of cells inside biomaterial hydrogels, ultimately aiming to allow for cell differentiation, matrix remodeling, and functional tissue analogues.
33666608	4	26	theme	oxidized	846:853	arg1	matrix					881:886	a non-fibrous oxidized alginate-gelatin hydrogel matrix	832:886	a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear	832:956	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	7	27	theme	cell	1264:1267	arg1	ml-1					1292:1295	≥6 mio ml-1	1285:1295	≥6 mio ml-1	1285:1295	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	7	27	theme	cell	1264:1267	arg1	concentrations					1269:1282	high cell concentrations	1259:1282	high cell concentrations (≥6 mio ml-1)	1259:1296	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	4	28	from	behavior	914:921	arg1	compression					926:936	compression	926:936	compression	926:936	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	4	28	from	behavior	914:921	arg1	tension					939:945	tension	939:945	tension	939:945	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	4	28	from	behavior	914:921	arg1	shear					952:956	shear	952:956	shear	952:956	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	1	29	dep	distribution	172:183	arg1	the					156:158	the	156:158	the	156:158	3D-printing technologies, such as biofabrication, capitalize on the homogeneous distribution and growth of cells inside biomaterial hydrogels, ultimately aiming to allow for cell differentiation, matrix remodeling, and functional tissue analogues.
33666608	2	30	theme	bioinks	397:403	arg1	materials					415:423	the bioinks or matrix materials	393:423	materials	415:423	However, commonly, only the mechanical properties of the bioinks or matrix materials are assessed, while the detailed influence of cells on the resulting mechanical properties of hydrogels remains insufficiently understood.
33666608	2	31	theme	detailed	449:456	arg1	influence					458:466	the detailed influence	445:466	the detailed influence of cells on the resulting mechanical properties of hydrogels	445:527	However, commonly, only the mechanical properties of the bioinks or matrix materials are assessed, while the detailed influence of cells on the resulting mechanical properties of hydrogels remains insufficiently understood.
33666608	8	32	theme	microgel	1519:1526	arg1	hydrogels					1552:1560	microgel bead drug carrier-laden hydrogels	1519:1560	microgel bead drug carrier-laden hydrogels	1519:1560	Our findings highlight cell concentration as a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering.
33666608	0	33	theme	cell-	25:29	arg1	properties					11:20	Mechanical properties	0:20	Mechanical properties of cell- and microgel	0:42	Mechanical properties of cell- and microgel bead-laden oxidized alginate-gelatin hydrogels.
33666608	5	34	theme	materials	1082:1090	arg1	response					1055:1062	the highly nonlinear mechanical response	1023:1062	the highly nonlinear mechanical response of soft composite materials	1023:1090	Through material modeling, we quantify parameters that describe the highly nonlinear mechanical response of soft composite materials.
33666608	4	35	from	contributions	779:791	arg1	behavior					914:921	the overall mechanical behavior	891:921	the overall mechanical behavior in compression, tension, and shear	891:956	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	4	36	theme	filler	806:811	arg1	concentrations					813:826	different filler concentrations	796:826	different filler concentrations	796:826	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	1	37	theme	biomaterial	212:222	arg1	hydrogels					224:232	biomaterial hydrogels	212:232	biomaterial hydrogels	212:232	3D-printing technologies, such as biofabrication, capitalize on the homogeneous distribution and growth of cells inside biomaterial hydrogels, ultimately aiming to allow for cell differentiation, matrix remodeling, and functional tissue analogues.
33666608	7	38	theme	high	1259:1262	arg1	ml-1					1292:1295	≥6 mio ml-1	1285:1295	≥6 mio ml-1	1285:1295	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	7	38	theme	high	1259:1262	arg1	concentrations					1269:1282	high cell concentrations	1259:1282	high cell concentrations (≥6 mio ml-1)	1259:1296	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	8	39	theme	carrier-laden	1538:1550	arg1	hydrogels					1552:1560	microgel bead drug carrier-laden hydrogels	1519:1560	microgel bead drug carrier-laden hydrogels	1519:1560	Our findings highlight cell concentration as a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering.
33666608	3	40	theme	complex	684:690	arg1	analyses					703:710	multi-modal complex mechanical analyses	672:710	multi-modal complex mechanical analyses in the small- and large-strain regimes	672:749	Here, we investigate the properties of hydrogels containing cells and spherical PAAm microgel beads through multi-modal complex mechanical analyses in the small- and large-strain regimes.
33666608	4	41	theme	different	796:804	arg1	concentrations					813:826	different filler concentrations	796:826	different filler concentrations	796:826	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	8	42	theme	final	1471:1475	arg1	mechanics					1486:1494	the final hydrogel mechanics	1467:1494	the final hydrogel mechanics	1467:1494	Our findings highlight cell concentration as a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering.
33666608	5	43	theme	mechanical	1044:1053	arg1	response					1055:1062	the highly nonlinear mechanical response	1023:1062	the highly nonlinear mechanical response of soft composite materials	1023:1090	Through material modeling, we quantify parameters that describe the highly nonlinear mechanical response of soft composite materials.
33666608	0	44	theme	microgel	35:42	arg1	properties					11:20	Mechanical properties	0:20	Mechanical properties of cell- and microgel	0:42	Mechanical properties of cell- and microgel bead-laden oxidized alginate-gelatin hydrogels.
33666608	1	45	theme	functional	311:320	arg1	analogues					329:337	functional tissue analogues	311:337	functional tissue analogues	311:337	3D-printing technologies, such as biofabrication, capitalize on the homogeneous distribution and growth of cells inside biomaterial hydrogels, ultimately aiming to allow for cell differentiation, matrix remodeling, and functional tissue analogues.
33666608	3	46	theme	mechanical	692:701	arg1	analyses					703:710	multi-modal complex mechanical analyses	672:710	multi-modal complex mechanical analyses in the small- and large-strain regimes	672:749	Here, we investigate the properties of hydrogels containing cells and spherical PAAm microgel beads through multi-modal complex mechanical analyses in the small- and large-strain regimes.
33666608	6	47	theme	cell-	1153:1157	arg1	concentrations					1168:1181	cell- and bead concentrations	1153:1181	cell- and bead concentrations exceeding four million per milliliter hydrogel	1153:1228	Our results show that the stiffness significantly drops for cell- and bead concentrations exceeding four million per milliliter hydrogel.
33666608	1	48	theme	tissue	322:327	arg1	analogues					329:337	functional tissue analogues	311:337	functional tissue analogues	311:337	3D-printing technologies, such as biofabrication, capitalize on the homogeneous distribution and growth of cells inside biomaterial hydrogels, ultimately aiming to allow for cell differentiation, matrix remodeling, and functional tissue analogues.
33666608	2	49	theme	materials	415:423	arg1	properties					379:388	only the mechanical properties	359:388	only the mechanical properties of the bioinks or matrix materials	359:423	However, commonly, only the mechanical properties of the bioinks or matrix materials are assessed, while the detailed influence of cells on the resulting mechanical properties of hydrogels remains insufficiently understood.
33666608	2	50	theme	cells	471:475	arg1	influence					458:466	the detailed influence	445:466	the detailed influence of cells on the resulting mechanical properties of hydrogels	445:527	However, commonly, only the mechanical properties of the bioinks or matrix materials are assessed, while the detailed influence of cells on the resulting mechanical properties of hydrogels remains insufficiently understood.
33666608	8	51	theme	crucial	1437:1443	arg1	parameter					1445:1453	a crucial parameter	1435:1453	a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering	1435:1600	Our findings highlight cell concentration as a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering.
33666608	8	51	theme	crucial	1437:1443	arg1	concentration					1418:1430	cell concentration	1413:1430	cell concentration	1413:1430	Our findings highlight cell concentration as a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering.
33666608	0	52	theme	alginate-gelatin	64:79	arg1	hydrogels					81:89	oxidized alginate-gelatin hydrogels	55:89	oxidized alginate-gelatin hydrogels	55:89	Mechanical properties of cell- and microgel bead-laden oxidized alginate-gelatin hydrogels.
33666608	3	53	theme	hydrogels	603:611	arg1	properties					589:598	the properties	585:598	the properties of hydrogels containing cells and spherical PAAm microgel beads	585:662	Here, we investigate the properties of hydrogels containing cells and spherical PAAm microgel beads through multi-modal complex mechanical analyses in the small- and large-strain regimes.
33666608	6	54	theme	milliliter	1210:1219	arg1	hydrogel					1221:1228	milliliter hydrogel	1210:1228	milliliter hydrogel	1210:1228	Our results show that the stiffness significantly drops for cell- and bead concentrations exceeding four million per milliliter hydrogel.
33666608	7	55	theme	faster	1364:1369	arg1	relaxation					1378:1387	faster stress relaxation	1364:1387	faster stress relaxation	1364:1387	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	8	56	theme	drug	1533:1536	arg1	hydrogels					1552:1560	microgel bead drug carrier-laden hydrogels	1519:1560	microgel bead drug carrier-laden hydrogels	1519:1560	Our findings highlight cell concentration as a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering.
33666608	8	57	theme	tissue	1583:1588	arg1	engineering					1590:1600	tissue engineering	1583:1600	tissue engineering	1583:1600	Our findings highlight cell concentration as a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering.
33666608	4	58	theme	overall	895:901	arg1	behavior					914:921	the overall mechanical behavior	891:921	the overall mechanical behavior in compression, tension, and shear	891:956	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	7	59	theme	stress	1371:1376	arg1	relaxation					1378:1387	faster stress relaxation	1364:1387	faster stress relaxation	1364:1387	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	8	60	theme	bead	1528:1531	arg1	hydrogels					1552:1560	microgel bead drug carrier-laden hydrogels	1519:1560	microgel bead drug carrier-laden hydrogels	1519:1560	Our findings highlight cell concentration as a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering.
33666608	4	61	theme	hydrogel	872:879	arg1	matrix					881:886	a non-fibrous oxidized alginate-gelatin hydrogel matrix	832:886	a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear	832:956	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	3	62	theme	small-	719:724	arg1	regimes					743:749	the small- and large-strain regimes	715:749	the small- and large-strain regimes	715:749	Here, we investigate the properties of hydrogels containing cells and spherical PAAm microgel beads through multi-modal complex mechanical analyses in the small- and large-strain regimes.
33666608	3	63	theme	microgel	649:656	arg1	beads					658:662	spherical PAAm microgel beads	634:662	spherical PAAm microgel beads	634:662	Here, we investigate the properties of hydrogels containing cells and spherical PAAm microgel beads through multi-modal complex mechanical analyses in the small- and large-strain regimes.
33666608	4	64	theme	individual	768:777	arg1	contributions					779:791	the individual contributions	764:791	the individual contributions of different filler concentrations	764:826	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	7	65	with	hydrogels	1244:1252	arg1	ml-1					1292:1295	≥6 mio ml-1	1285:1295	≥6 mio ml-1	1285:1295	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	7	65	with	hydrogels	1244:1252	arg1	concentrations					1269:1282	high cell concentrations	1259:1282	high cell concentrations (≥6 mio ml-1)	1259:1296	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	3	66	theme	beads	658:662	arg1	properties					589:598	the properties	585:598	the properties of hydrogels containing cells and spherical PAAm microgel beads	585:662	Here, we investigate the properties of hydrogels containing cells and spherical PAAm microgel beads through multi-modal complex mechanical analyses in the small- and large-strain regimes.
33666608	4	67	from	matrix	881:886	arg1	behavior					914:921	the overall mechanical behavior	891:921	the overall mechanical behavior in compression, tension, and shear	891:956	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	7	68	theme	larger	1345:1350	arg1	strains					1352:1358	larger strains	1345:1358	larger strains	1345:1358	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	4	69	theme	alginate-gelatin	855:870	arg1	matrix					881:886	a non-fibrous oxidized alginate-gelatin hydrogel matrix	832:886	a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear	832:956	We evaluate the individual contributions of different filler concentrations and a non-fibrous oxidized alginate-gelatin hydrogel matrix on the overall mechanical behavior in compression, tension, and shear.
33666608	3	70	from	analyses	703:710	arg1	regimes					743:749	the small- and large-strain regimes	715:749	the small- and large-strain regimes	715:749	Here, we investigate the properties of hydrogels containing cells and spherical PAAm microgel beads through multi-modal complex mechanical analyses in the small- and large-strain regimes.
33666608	3	71	theme	spherical	634:642	arg1	beads					658:662	spherical PAAm microgel beads	634:662	spherical PAAm microgel beads	634:662	Here, we investigate the properties of hydrogels containing cells and spherical PAAm microgel beads through multi-modal complex mechanical analyses in the small- and large-strain regimes.
33666608	8	72	theme	cell	1413:1416	arg1	parameter					1445:1453	a crucial parameter	1435:1453	a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering	1435:1600	Our findings highlight cell concentration as a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering.
33666608	8	72	theme	cell	1413:1416	arg1	concentration					1418:1430	cell concentration	1413:1430	cell concentration	1413:1430	Our findings highlight cell concentration as a crucial parameter influencing the final hydrogel mechanics, with implications for microgel bead drug carrier-laden hydrogels, biofabrication, and tissue engineering.
33666608	7	73	theme	pronounced	1308:1317	arg1	nonlinearity					1328:1339	more pronounced material nonlinearity	1303:1339	more pronounced material nonlinearity for larger strains and faster stress relaxation	1303:1387	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33666608	0	74	theme	oxidized	55:62	arg1	hydrogels					81:89	oxidized alginate-gelatin hydrogels	55:89	oxidized alginate-gelatin hydrogels	55:89	Mechanical properties of cell- and microgel bead-laden oxidized alginate-gelatin hydrogels.
33666608	3	75	theme	PAAm	644:647	arg1	beads					658:662	spherical PAAm microgel beads	634:662	spherical PAAm microgel beads	634:662	Here, we investigate the properties of hydrogels containing cells and spherical PAAm microgel beads through multi-modal complex mechanical analyses in the small- and large-strain regimes.
33666608	1	76	theme	homogeneous	160:170	arg1	distribution					172:183	homogeneous distribution	160:183	homogeneous distribution	160:183	3D-printing technologies, such as biofabrication, capitalize on the homogeneous distribution and growth of cells inside biomaterial hydrogels, ultimately aiming to allow for cell differentiation, matrix remodeling, and functional tissue analogues.
33666608	7	77	theme	material	1319:1326	arg1	nonlinearity					1328:1339	more pronounced material nonlinearity	1303:1339	more pronounced material nonlinearity for larger strains and faster stress relaxation	1303:1387	In addition, hydrogels with high cell concentrations (≥6 mio ml-1) show more pronounced material nonlinearity for larger strains and faster stress relaxation.
33035694	5	0	theme	matrix	757:762	arg1	capacity					774:781	their high matrix synthesis capacity	746:781	their high matrix synthesis capacity potential post-expansion	746:806	Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair.
33035694	6	1	dep	derived	988:994	arg1	disc					983:986	disc	983:986	disc	983:986	The overall goal of this study was to assess the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs.
33035694	2	2	theme	extracellular	364:376	arg1	components					391:400	key extracellular matrix (ECM) components	360:400	key extracellular matrix (ECM) components	360:400	The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components.
33035694	6	3	theme	incorporation	964:976	arg1	effects					950:956	the effects	946:956	the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs	946:1055	The overall goal of this study was to assess the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs.
33035694	0	4	theme	Disc	96:99	arg1	Regeneration					101:112	Intervertebral Disc Regeneration	81:112	Intervertebral Disc Regeneration	81:112	Injectable Disc-Derived ECM Hydrogel Functionalised with Chondroitin Sulfate for Intervertebral Disc Regeneration.
33035694	7	5	theme	sGAG	1086:1089	arg1	production					1091:1100	an increased sGAG production	1073:1100	an increased sGAG production with higher amounts of CS in the gel composition	1073:1149	Results showed an increased sGAG production with higher amounts of CS in the gel composition and that its presence was found to be critical for the synthesis of collagen type II.
33035694	2	6	theme	key	360:362	arg1	components					391:400	key extracellular matrix (ECM) components	360:400	key extracellular matrix (ECM) components	360:400	The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components.
33035694	6	7	theme	CS	961:962	arg1	incorporation					964:976	CS incorporation	961:976	CS incorporation into disc derived self-assembled ECM hydrogels	961:1023	The overall goal of this study was to assess the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs.
33035694	7	8	with	production	1091:1100	arg1	CS					1125:1126	CS	1125:1126	CS	1125:1126	Results showed an increased sGAG production with higher amounts of CS in the gel composition and that its presence was found to be critical for the synthesis of collagen type II.
33035694	7	8	with	production	1091:1100	arg1	amounts					1114:1120	higher amounts	1107:1120	higher amounts of CS	1107:1126	Results showed an increased sGAG production with higher amounts of CS in the gel composition and that its presence was found to be critical for the synthesis of collagen type II.
33035694	7	9	theme	collagen	1219:1226	arg1	type					1228:1231	collagen type II	1219:1234	collagen type II	1219:1234	Results showed an increased sGAG production with higher amounts of CS in the gel composition and that its presence was found to be critical for the synthesis of collagen type II.
33035694	7	10	theme	increased	1076:1084	arg1	production					1091:1100	an increased sGAG production	1073:1100	an increased sGAG production with higher amounts of CS in the gel composition	1073:1149	Results showed an increased sGAG production with higher amounts of CS in the gel composition and that its presence was found to be critical for the synthesis of collagen type II.
33035694	2	11	theme	pulposus	305:312	arg1	alteration					279:288	the alteration	275:288	the alteration of the nucleus pulposus (NP)	275:317	The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components.
33035694	8	12	theme	3D	1400:1401	arg1	culture					1403:1409	3D culture	1400:1409	3D culture	1400:1409	Taken together, our results demonstrate how the inclusion of CS into the composition of the material aids the preservation of a rounded cell morphology for NCs in 3D culture and enhances their ability to synthesise NP-like matrix.
33035694	8	13	theme	NP-like	1452:1458	arg1	matrix					1460:1465	NP-like matrix	1452:1465	NP-like matrix	1452:1465	Taken together, our results demonstrate how the inclusion of CS into the composition of the material aids the preservation of a rounded cell morphology for NCs in 3D culture and enhances their ability to synthesise NP-like matrix.
33035694	3	14	theme	IVD	563:565	arg1	repair					567:572	IVD repair	563:572	IVD repair	563:572	Thus, the development of injectable and biomimetic biomaterials that can instruct the regenerative cell component to produce tissue-specific ECM is pivotal for IVD repair.
33035694	2	15	theme	nucleus	297:303	arg1	NP					315:316	NP	315:316	NP	315:316	The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components.
33035694	2	15	theme	nucleus	297:303	arg1	pulposus					305:312	the nucleus pulposus	293:312	the nucleus pulposus (NP)	293:317	The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components.
33035694	2	16	theme	cell-mediated	323:335	arg1	breakdown					347:355	cell-mediated enzymatic breakdown	323:355	cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components	323:400	The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components.
33035694	7	17	theme	type	1228:1231	arg1	synthesis					1206:1214	the synthesis	1202:1214	the synthesis of collagen type II	1202:1234	Results showed an increased sGAG production with higher amounts of CS in the gel composition and that its presence was found to be critical for the synthesis of collagen type II.
33035694	3	18	theme	regenerative	489:500	arg1	component					507:515	the regenerative cell component	485:515	the regenerative cell component to produce tissue-specific ECM	485:546	Thus, the development of injectable and biomimetic biomaterials that can instruct the regenerative cell component to produce tissue-specific ECM is pivotal for IVD repair.
33035694	6	19	theme	self-assembled	996:1009	arg1	hydrogels					1015:1023	disc derived self-assembled ECM hydrogels	983:1023	disc derived self-assembled ECM hydrogels	983:1023	The overall goal of this study was to assess the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs.
33035694	5	20	theme	potential	857:865	arg1	chondrocytes					815:826	nasal chondrocytes	809:826	nasal chondrocytes (NC)	809:831	Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair.
33035694	5	20	theme	potential	857:865	arg1	source					872:877	a potential cell source	855:877	a potential cell source to promote NP repair	855:898	Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair.
33035694	4	21	theme	tissue	654:659	arg1	components					637:646	the primary components	625:646	the primary components of NP tissue	625:659	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	4	21	theme	tissue	654:659	arg1	collagen					612:619	type II collagen	604:619	type II collagen	604:619	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	4	21	theme	tissue	654:659	arg1	sulfate					587:593	Chondroitin sulfate	575:593	Chondroitin sulfate (CS)	575:598	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	5	22	theme	NP	890:891	arg1	repair					893:898	NP repair	890:898	NP repair	890:898	Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair.
33035694	3	23	theme	injectable	428:437	arg1	biomaterials					454:465	injectable and biomimetic biomaterials	428:465	injectable and biomimetic biomaterials that can instruct the regenerative cell component to produce tissue-specific ECM	428:546	Thus, the development of injectable and biomimetic biomaterials that can instruct the regenerative cell component to produce tissue-specific ECM is pivotal for IVD repair.
33035694	4	24	theme	type	604:607	arg1	components					637:646	the primary components	625:646	the primary components of NP tissue	625:659	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	4	24	theme	type	604:607	arg1	collagen					612:619	type II collagen	604:619	type II collagen	604:619	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	4	24	theme	type	604:607	arg1	sulfate					587:593	Chondroitin sulfate	575:593	Chondroitin sulfate (CS)	575:598	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	2	25	theme	components	391:400	arg1	breakdown					347:355	cell-mediated enzymatic breakdown	323:355	cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components	323:400	The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components.
33035694	0	26	theme	Disc-Derived	11:22	arg1	Hydrogel					28:35	Injectable Disc-Derived ECM Hydrogel	0:35	Injectable Disc-Derived ECM Hydrogel	0:35	Injectable Disc-Derived ECM Hydrogel Functionalised with Chondroitin Sulfate for Intervertebral Disc Regeneration.
33035694	5	27	theme	synthesis	764:772	arg1	capacity					774:781	their high matrix synthesis capacity	746:781	their high matrix synthesis capacity potential post-expansion	746:806	Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair.
33035694	6	28	theme	NCs	1053:1055	arg1	deposition					1039:1048	the matrix deposition	1028:1048	the matrix deposition of NCs	1028:1055	The overall goal of this study was to assess the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs.
33035694	4	29	theme	NP	651:652	arg1	tissue					654:659	NP tissue	651:659	NP tissue	651:659	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	7	30	theme	gel	1135:1137	arg1	composition					1139:1149	the gel composition	1131:1149	the gel composition	1131:1149	Results showed an increased sGAG production with higher amounts of CS in the gel composition and that its presence was found to be critical for the synthesis of collagen type II.
33035694	1	31	theme	significant	188:198	arg1	burden					214:219	a significant socioeconomic burden	186:219	a significant socioeconomic burden	186:219	Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden.
33035694	1	31	theme	significant	188:198	arg1	pain					124:127	Low back pain	115:127	Low back pain resulting from intervertebral disc (IVD) degeneration	115:181	Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden.
33035694	0	32	theme	Injectable	0:9	arg1	Hydrogel					28:35	Injectable Disc-Derived ECM Hydrogel	0:35	Injectable Disc-Derived ECM Hydrogel	0:35	Injectable Disc-Derived ECM Hydrogel Functionalised with Chondroitin Sulfate for Intervertebral Disc Regeneration.
33035694	1	33	theme	Low	115:117	arg1	burden					214:219	a significant socioeconomic burden	186:219	a significant socioeconomic burden	186:219	Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden.
33035694	1	33	theme	Low	115:117	arg1	pain					124:127	Low back pain	115:127	Low back pain resulting from intervertebral disc (IVD) degeneration	115:181	Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden.
33035694	2	34	theme	ECM	386:388	arg1	components					391:400	key extracellular matrix (ECM) components	360:400	key extracellular matrix (ECM) components	360:400	The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components.
33035694	4	35	theme	de-novo	724:730	arg1	matrix					732:737	de-novo matrix	724:737	de-novo matrix	724:737	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	8	36	theme	material	1329:1336	arg1	composition					1310:1320	the composition	1306:1320	the composition of the material	1306:1336	Taken together, our results demonstrate how the inclusion of CS into the composition of the material aids the preservation of a rounded cell morphology for NCs in 3D culture and enhances their ability to synthesise NP-like matrix.
33035694	4	37	theme	primary	629:635	arg1	components					637:646	the primary components	625:646	the primary components of NP tissue	625:659	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	4	37	theme	primary	629:635	arg1	collagen					612:619	type II collagen	604:619	type II collagen	604:619	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	4	37	theme	primary	629:635	arg1	sulfate					587:593	Chondroitin sulfate	575:593	Chondroitin sulfate (CS)	575:598	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	0	38	theme	ECM	24:26	arg1	Hydrogel					28:35	Injectable Disc-Derived ECM Hydrogel	0:35	Injectable Disc-Derived ECM Hydrogel	0:35	Injectable Disc-Derived ECM Hydrogel Functionalised with Chondroitin Sulfate for Intervertebral Disc Regeneration.
33035694	8	39	from	NCs	1393:1395	arg1	culture					1403:1409	3D culture	1400:1409	3D culture	1400:1409	Taken together, our results demonstrate how the inclusion of CS into the composition of the material aids the preservation of a rounded cell morphology for NCs in 3D culture and enhances their ability to synthesise NP-like matrix.
33035694	8	40	theme	CS	1298:1299	arg1	inclusion					1285:1293	the inclusion	1281:1293	the inclusion of CS into the composition of the material	1281:1336	Taken together, our results demonstrate how the inclusion of CS into the composition of the material aids the preservation of a rounded cell morphology for NCs in 3D culture and enhances their ability to synthesise NP-like matrix.
33035694	8	41	theme	morphology	1378:1387	arg1	preservation					1347:1358	the preservation	1343:1358	the preservation of a rounded cell morphology for NCs in 3D culture	1343:1409	Taken together, our results demonstrate how the inclusion of CS into the composition of the material aids the preservation of a rounded cell morphology for NCs in 3D culture and enhances their ability to synthesise NP-like matrix.
33035694	4	42	theme	ideal	685:689	arg1	environment					691:701	the ideal environment	681:701	the ideal environment for cells to deposit de-novo matrix	681:737	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	5	43	theme	capacity	774:781	arg1	post-expansion					793:806	their high matrix synthesis capacity potential post-expansion	746:806	their high matrix synthesis capacity potential post-expansion	746:806	Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair.
33035694	4	44	theme	Chondroitin	575:585	arg1	components					637:646	the primary components	625:646	the primary components of NP tissue	625:659	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	4	44	theme	Chondroitin	575:585	arg1	collagen					612:619	type II collagen	604:619	type II collagen	604:619	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	4	44	theme	Chondroitin	575:585	arg1	CS					596:597	CS	596:597	CS	596:597	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	4	44	theme	Chondroitin	575:585	arg1	sulfate					587:593	Chondroitin sulfate	575:593	Chondroitin sulfate (CS)	575:598	Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix.
33035694	8	45	theme	cell	1373:1376	arg1	morphology					1378:1387	a rounded cell morphology	1363:1387	a rounded cell morphology for NCs in 3D culture	1363:1409	Taken together, our results demonstrate how the inclusion of CS into the composition of the material aids the preservation of a rounded cell morphology for NCs in 3D culture and enhances their ability to synthesise NP-like matrix.
33035694	2	46	theme	degeneration	245:256	arg1	process					258:264	the degeneration process	241:264	the degeneration process	241:264	The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components.
33035694	1	47	theme	socioeconomic	200:212	arg1	burden					214:219	a significant socioeconomic burden	186:219	a significant socioeconomic burden	186:219	Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden.
33035694	1	47	theme	socioeconomic	200:212	arg1	pain					124:127	Low back pain	115:127	Low back pain resulting from intervertebral disc (IVD) degeneration	115:181	Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden.
33035694	3	48	theme	biomaterials	454:465	arg1	pivotal					551:557	pivotal	551:557	pivotal	551:557	Thus, the development of injectable and biomimetic biomaterials that can instruct the regenerative cell component to produce tissue-specific ECM is pivotal for IVD repair.
33035694	3	48	theme	biomaterials	454:465	arg1	development					413:423	the development	409:423	the development of injectable and biomimetic biomaterials that can instruct the regenerative cell component to produce tissue-specific ECM	409:546	Thus, the development of injectable and biomimetic biomaterials that can instruct the regenerative cell component to produce tissue-specific ECM is pivotal for IVD repair.
33035694	5	49	theme	potential	783:791	arg1	post-expansion					793:806	their high matrix synthesis capacity potential post-expansion	746:806	their high matrix synthesis capacity potential post-expansion	746:806	Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair.
33035694	6	50	theme	study	926:930	arg1	goal					913:916	The overall goal	901:916	The overall goal of this study	901:930	The overall goal of this study was to assess the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs.
33035694	7	51	theme	CS	1125:1126	arg1	CS					1125:1126	CS	1125:1126	CS	1125:1126	Results showed an increased sGAG production with higher amounts of CS in the gel composition and that its presence was found to be critical for the synthesis of collagen type II.
33035694	7	51	theme	CS	1125:1126	arg1	amounts					1114:1120	higher amounts	1107:1120	higher amounts of CS	1107:1126	Results showed an increased sGAG production with higher amounts of CS in the gel composition and that its presence was found to be critical for the synthesis of collagen type II.
33035694	6	52	theme	ECM	1011:1013	arg1	hydrogels					1015:1023	disc derived self-assembled ECM hydrogels	983:1023	disc derived self-assembled ECM hydrogels	983:1023	The overall goal of this study was to assess the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs.
33035694	7	53	theme	higher	1107:1112	arg1	CS					1125:1126	CS	1125:1126	CS	1125:1126	Results showed an increased sGAG production with higher amounts of CS in the gel composition and that its presence was found to be critical for the synthesis of collagen type II.
33035694	7	53	theme	higher	1107:1112	arg1	amounts					1114:1120	higher amounts	1107:1120	higher amounts of CS	1107:1126	Results showed an increased sGAG production with higher amounts of CS in the gel composition and that its presence was found to be critical for the synthesis of collagen type II.
33035694	3	54	theme	cell	502:505	arg1	component					507:515	the regenerative cell component	485:515	the regenerative cell component to produce tissue-specific ECM	485:546	Thus, the development of injectable and biomimetic biomaterials that can instruct the regenerative cell component to produce tissue-specific ECM is pivotal for IVD repair.
33035694	0	55	theme	Chondroitin	57:67	arg1	Sulfate					69:75	Chondroitin Sulfate	57:75	Chondroitin Sulfate	57:75	Injectable Disc-Derived ECM Hydrogel Functionalised with Chondroitin Sulfate for Intervertebral Disc Regeneration.
33035694	7	56	from	production	1091:1100	arg1	composition					1139:1149	the gel composition	1131:1149	the gel composition	1131:1149	Results showed an increased sGAG production with higher amounts of CS in the gel composition and that its presence was found to be critical for the synthesis of collagen type II.
33035694	2	57	theme	main	226:229	arg1	effect					231:236	The main effect	222:236	The main effect of the degeneration process	222:264	The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components.
33035694	1	58	theme	IVD	165:167	arg1	degeneration					170:181	intervertebral disc (IVD) degeneration	144:181	intervertebral disc (IVD) degeneration	144:181	Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden.
33035694	6	59	theme	derived	988:994	arg1	hydrogels					1015:1023	disc derived self-assembled ECM hydrogels	983:1023	disc derived self-assembled ECM hydrogels	983:1023	The overall goal of this study was to assess the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs.
33035694	1	60	theme	intervertebral	144:157	arg1	degeneration					170:181	intervertebral disc (IVD) degeneration	144:181	intervertebral disc (IVD) degeneration	144:181	Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden.
33035694	5	61	theme	cell	867:870	arg1	chondrocytes					815:826	nasal chondrocytes	809:826	nasal chondrocytes (NC)	809:831	Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair.
33035694	5	61	theme	cell	867:870	arg1	source					872:877	a potential cell source	855:877	a potential cell source to promote NP repair	855:898	Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair.
33035694	5	62	theme	nasal	809:813	arg1	chondrocytes					815:826	nasal chondrocytes	809:826	nasal chondrocytes (NC)	809:831	Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair.
33035694	5	62	theme	nasal	809:813	arg1	source					872:877	a potential cell source	855:877	a potential cell source to promote NP repair	855:898	Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair.
33035694	5	62	theme	nasal	809:813	arg1	NC					829:830	NC	829:830	NC	829:830	Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair.
33035694	6	63	link	derived	988:994	arg1	hydrogels					1015:1023	disc derived self-assembled ECM hydrogels	983:1023	disc derived self-assembled ECM hydrogels	983:1023	The overall goal of this study was to assess the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs.
33035694	6	64	from	effects	950:956	arg1	deposition					1039:1048	the matrix deposition	1028:1048	the matrix deposition of NCs	1028:1055	The overall goal of this study was to assess the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs.
33035694	6	65	theme	matrix	1032:1037	arg1	deposition					1039:1048	the matrix deposition	1028:1048	the matrix deposition of NCs	1028:1055	The overall goal of this study was to assess the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs.
33035694	1	66	theme	disc	159:162	arg1	degeneration					170:181	intervertebral disc (IVD) degeneration	144:181	intervertebral disc (IVD) degeneration	144:181	Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden.
33035694	2	67	theme	enzymatic	337:345	arg1	breakdown					347:355	cell-mediated enzymatic breakdown	323:355	cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components	323:400	The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components.
33035694	0	68	theme	Intervertebral	81:94	arg1	Regeneration					101:112	Intervertebral Disc Regeneration	81:112	Intervertebral Disc Regeneration	81:112	Injectable Disc-Derived ECM Hydrogel Functionalised with Chondroitin Sulfate for Intervertebral Disc Regeneration.
33035694	8	69	theme	rounded	1365:1371	arg1	morphology					1378:1387	a rounded cell morphology	1363:1387	a rounded cell morphology for NCs in 3D culture	1363:1409	Taken together, our results demonstrate how the inclusion of CS into the composition of the material aids the preservation of a rounded cell morphology for NCs in 3D culture and enhances their ability to synthesise NP-like matrix.
33035694	3	70	theme	tissue-specific	528:542	arg1	ECM					544:546	tissue-specific ECM	528:546	tissue-specific ECM	528:546	Thus, the development of injectable and biomimetic biomaterials that can instruct the regenerative cell component to produce tissue-specific ECM is pivotal for IVD repair.
33035694	3	71	theme	biomimetic	443:452	arg1	biomaterials					454:465	injectable and biomimetic biomaterials	428:465	injectable and biomimetic biomaterials that can instruct the regenerative cell component to produce tissue-specific ECM	428:546	Thus, the development of injectable and biomimetic biomaterials that can instruct the regenerative cell component to produce tissue-specific ECM is pivotal for IVD repair.
33035694	5	72	theme	high	752:755	arg1	capacity					774:781	their high matrix synthesis capacity	746:781	their high matrix synthesis capacity potential post-expansion	746:806	Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair.
33035694	6	73	theme	overall	905:911	arg1	goal					913:916	The overall goal	901:916	The overall goal of this study	901:930	The overall goal of this study was to assess the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs.
33035694	2	74	theme	process	258:264	arg1	effect					231:236	The main effect	222:236	The main effect of the degeneration process	222:264	The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components.
33035694	2	75	theme	matrix	378:383	arg1	components					391:400	key extracellular matrix (ECM) components	360:400	key extracellular matrix (ECM) components	360:400	The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components.
34289441	0	0	theme	sensitive	100:108	arg1	determination					110:122	sensitive determination	100:122	sensitive determination of niclosamide	100:137	Three-dimensional hierarchical porous carbon coupled with chitosan based electrochemical sensor for sensitive determination of niclosamide.
34289441	2	1	theme	self-generated	529:542	arg1	groups					573:578	self-generated oxygen-containing functional groups	529:578	self-generated oxygen-containing functional groups	529:578	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	2	2	theme	LiBr/KBr	673:680	arg1	source					642:647	carbon source	635:647	carbon source	635:647	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	2	2	theme	LiBr/KBr	673:680	arg1	mixture					662:668	eutectic mixture	653:668	eutectic mixture	653:668	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	7	3	theme	niclosamide	1582:1592	arg1	determination					1565:1577	the sensitive determination	1551:1577	the sensitive determination of niclosamide in food samples	1551:1608	This work provides a very valuable reference for the sensitive determination of niclosamide in food samples.
34289441	3	4	with	chitosan	767:774	arg1	dispersibility					845:858	good dispersibility	840:858	good dispersibility	840:858	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	3	4	with	chitosan	767:774	arg1	ability					827:833	strong adsorption ability	809:833	strong adsorption ability	809:833	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	3	4	with	chitosan	767:774	arg1	property					799:806	excellent filming property	781:806	excellent filming property	781:806	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	3	5	theme	excellent	781:789	arg1	property					799:806	excellent filming property	781:806	excellent filming property	781:806	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	7	6	from	niclosamide	1582:1592	arg1	samples					1602:1608	food samples	1597:1608	food samples	1597:1608	This work provides a very valuable reference for the sensitive determination of niclosamide in food samples.
34289441	4	7	theme	concentration	1174:1186	arg1	range					1188:1192	the linear concentration range	1163:1192	the linear concentration range from 0.01 to 10 µM	1163:1211	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	1	8	theme	chitosan	288:295	arg1	chitosan					288:295	chitosan	288:295	chitosan	288:295	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	1	8	theme	chitosan	288:295	arg1	carbon					277:282	three-dimensional hierarchical porous carbon	239:282	three-dimensional hierarchical porous carbon	239:282	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	1	8	theme	chitosan	288:295	arg1	composite					226:234	the composite	222:234	the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide	222:427	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	1	9	theme	electrochemical	369:383	arg1	sensor					385:390	an electrochemical sensor	366:390	an electrochemical sensor for the determination of niclosamide	366:427	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	6	10	theme	niclosamide	1385:1395	arg1	detection					1372:1380	the detection	1368:1380	the detection of niclosamide	1368:1395	Most important, the decent practicability for the detection of niclosamide was obtained in different food samples with low relative standard deviation and satisfactory recoveries.
34289441	7	11	theme	sensitive	1555:1563	arg1	determination					1565:1577	the sensitive determination	1551:1577	the sensitive determination of niclosamide in food samples	1551:1608	This work provides a very valuable reference for the sensitive determination of niclosamide in food samples.
34289441	3	12	theme	niclosamide	969:979	arg1	performance					954:964	the determination performance	936:964	the determination performance of niclosamide	936:979	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	3	13	theme	porous	903:908	arg1	carbon					910:915	the obtained porous carbon	890:915	the obtained porous carbon to further enhance the determination performance of niclosamide	890:979	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	4	14	theme	carbon	1073:1078	arg1	integration					1020:1030	the multi-functional integration	999:1030	the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan	999:1091	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	2	15	theme	eutectic	653:660	arg1	mixture					662:668	eutectic mixture	653:668	eutectic mixture	653:668	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	1	16	dep	simple	150:155	arg1	low-cost					158:165	low-cost	158:165	low-cost	158:165	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	1	16	dep	simple	150:155	arg1	environment-friendly					168:187	environment-friendly	168:187	environment-friendly	168:187	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	6	17	theme	standard	1454:1461	arg1	deviation					1463:1471	low relative standard deviation	1441:1471	low relative standard deviation	1441:1471	Most important, the decent practicability for the detection of niclosamide was obtained in different food samples with low relative standard deviation and satisfactory recoveries.
34289441	3	18	theme	strong	809:814	arg1	ability					827:833	strong adsorption ability	809:833	strong adsorption ability	809:833	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	2	19	theme	pore-forming	705:716	arg1	agent					718:722	both activating and pore-forming agent	685:722	both activating and pore-forming agent	685:722	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	4	20	theme	linear	1167:1172	arg1	range					1188:1192	the linear concentration range	1163:1192	the linear concentration range from 0.01 to 10 µM	1163:1211	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	0	21	theme	niclosamide	127:137	arg1	determination					110:122	sensitive determination	100:122	sensitive determination of niclosamide	100:137	Three-dimensional hierarchical porous carbon coupled with chitosan based electrochemical sensor for sensitive determination of niclosamide.
34289441	3	22	theme	filming	791:797	arg1	property					799:806	excellent filming property	781:806	excellent filming property	781:806	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	2	23	theme	activating	690:699	arg1	agent					718:722	both activating and pore-forming agent	685:722	both activating and pore-forming agent	685:722	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	3	24	theme	obtained	894:901	arg1	carbon					910:915	the obtained porous carbon	890:915	the obtained porous carbon to further enhance the determination performance of niclosamide	890:979	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	3	25	theme	good	840:843	arg1	dispersibility					845:858	good dispersibility	840:858	good dispersibility	840:858	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	0	26	theme	hierarchical	18:29	arg1	carbon					38:43	Three-dimensional hierarchical porous carbon	0:43	Three-dimensional hierarchical porous carbon coupled with chitosan	0:65	Three-dimensional hierarchical porous carbon coupled with chitosan based electrochemical sensor for sensitive determination of niclosamide.
34289441	2	27	with	carbon	459:464	arg1	network					497:503	interconnected conductive network	471:503	interconnected conductive network	471:503	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	2	27	with	carbon	459:464	arg1	area					519:522	high surface area	506:522	high surface area	506:522	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	2	27	with	carbon	459:464	arg1	groups					573:578	self-generated oxygen-containing functional groups	529:578	self-generated oxygen-containing functional groups	529:578	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	7	28	from	samples	1602:1608	arg1	determination					1565:1577	the sensitive determination	1551:1577	the sensitive determination of niclosamide in food samples	1551:1608	This work provides a very valuable reference for the sensitive determination of niclosamide in food samples.
34289441	4	29	theme	fabricated	1098:1107	arg1	sensor					1109:1114	the fabricated sensor	1094:1114	the fabricated sensor	1094:1114	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	7	30	theme	valuable	1528:1535	arg1	reference					1537:1545	a very valuable reference	1521:1545	a very valuable reference for the sensitive determination of niclosamide in food samples	1521:1608	This work provides a very valuable reference for the sensitive determination of niclosamide in food samples.
34289441	7	31	theme	food	1597:1600	arg1	samples					1602:1608	food samples	1597:1608	food samples	1597:1608	This work provides a very valuable reference for the sensitive determination of niclosamide in food samples.
34289441	0	32	theme	Three-dimensional	0:16	arg1	carbon					38:43	Three-dimensional hierarchical porous carbon	0:43	Three-dimensional hierarchical porous carbon coupled with chitosan	0:65	Three-dimensional hierarchical porous carbon coupled with chitosan based electrochemical sensor for sensitive determination of niclosamide.
34289441	4	33	theme	detection	1141:1149	arg1	limit					1132:1136	a low limit	1126:1136	a low limit of detection (6.7 nM)	1126:1158	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	2	34	theme	conductive	486:495	arg1	network					497:503	interconnected conductive network	471:503	interconnected conductive network	471:503	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	6	35	theme	different	1413:1421	arg1	samples					1428:1434	different food samples	1413:1434	different food samples with low relative standard deviation and satisfactory recoveries	1413:1499	Most important, the decent practicability for the detection of niclosamide was obtained in different food samples with low relative standard deviation and satisfactory recoveries.
34289441	4	36	theme	three-dimensional	1035:1051	arg1	carbon					1073:1078	three-dimensional hierarchical porous carbon	1035:1078	three-dimensional hierarchical porous carbon	1035:1078	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	0	37	theme	porous	31:36	arg1	carbon					38:43	Three-dimensional hierarchical porous carbon	0:43	Three-dimensional hierarchical porous carbon coupled with chitosan	0:65	Three-dimensional hierarchical porous carbon coupled with chitosan based electrochemical sensor for sensitive determination of niclosamide.
34289441	3	38	theme	adsorption	816:825	arg1	ability					827:833	strong adsorption ability	809:833	strong adsorption ability	809:833	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	6	39	theme	relative	1445:1452	arg1	deviation					1463:1471	low relative standard deviation	1441:1471	low relative standard deviation	1441:1471	Most important, the decent practicability for the detection of niclosamide was obtained in different food samples with low relative standard deviation and satisfactory recoveries.
34289441	6	40	with	samples	1428:1434	arg1	deviation					1463:1471	low relative standard deviation	1441:1471	low relative standard deviation	1441:1471	Most important, the decent practicability for the detection of niclosamide was obtained in different food samples with low relative standard deviation and satisfactory recoveries.
34289441	6	40	with	samples	1428:1434	arg1	recoveries					1490:1499	satisfactory recoveries	1477:1499	satisfactory recoveries	1477:1499	Most important, the decent practicability for the detection of niclosamide was obtained in different food samples with low relative standard deviation and satisfactory recoveries.
34289441	4	41	theme	low	1128:1130	arg1	limit					1132:1136	a low limit	1126:1136	a low limit of detection (6.7 nM)	1126:1158	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	4	42	theme	porous	1066:1071	arg1	carbon					1073:1078	three-dimensional hierarchical porous carbon	1035:1078	three-dimensional hierarchical porous carbon	1035:1078	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	1	43	theme	niclosamide	417:427	arg1	determination					400:412	the determination	396:412	the determination of niclosamide	396:427	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	6	44	theme	decent	1342:1347	arg1	practicability					1349:1362	the decent practicability	1338:1362	the decent practicability for the detection of niclosamide	1338:1395	Most important, the decent practicability for the detection of niclosamide was obtained in different food samples with low relative standard deviation and satisfactory recoveries.
34289441	2	45	theme	porous	452:457	arg1	carbon					459:464	The three-dimensional porous carbon	430:464	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups	430:578	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	3	46	theme	determination	940:952	arg1	performance					954:964	the determination performance	936:964	the determination performance of niclosamide	936:979	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	4	47	theme	hierarchical	1053:1064	arg1	carbon					1073:1078	three-dimensional hierarchical porous carbon	1035:1078	three-dimensional hierarchical porous carbon	1035:1078	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	6	48	theme	low	1441:1443	arg1	deviation					1463:1471	low relative standard deviation	1441:1471	low relative standard deviation	1441:1471	Most important, the decent practicability for the detection of niclosamide was obtained in different food samples with low relative standard deviation and satisfactory recoveries.
34289441	4	49	from	10 µM	1207:1211	arg1	range					1188:1192	the linear concentration range	1163:1192	the linear concentration range from 0.01 to 10 µM	1163:1211	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	2	50	theme	three-dimensional	434:450	arg1	carbon					459:464	The three-dimensional porous carbon	430:464	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups	430:578	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	2	51	theme	surface	511:517	arg1	area					519:522	high surface area	506:522	high surface area	506:522	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	1	52	theme	glass	330:334	arg1	electrode					343:351	the glass carbon electrode	326:351	the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide	326:427	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	2	53	theme	oxygen-containing	544:560	arg1	groups					573:578	self-generated oxygen-containing functional groups	529:578	self-generated oxygen-containing functional groups	529:578	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	4	54	dep	10 µM	1207:1211	arg1	to					1204:1205	to	1204:1205	to	1204:1205	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	2	55	theme	high	506:509	arg1	area					519:522	high surface area	506:522	high surface area	506:522	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	1	56	theme	carbon	336:341	arg1	electrode					343:351	the glass carbon electrode	326:351	the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide	326:427	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	6	57	theme	food	1423:1426	arg1	samples					1428:1434	different food samples	1413:1434	different food samples with low relative standard deviation and satisfactory recoveries	1413:1499	Most important, the decent practicability for the detection of niclosamide was obtained in different food samples with low relative standard deviation and satisfactory recoveries.
34289441	3	58	theme	ultrasonic	747:756	arg1	process					758:764	the subsequent ultrasonic process	732:764	the subsequent ultrasonic process	732:764	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	2	59	with	method	612:617	arg1	glucose					624:630	glucose	624:630	glucose	624:630	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	2	60	theme	carbon	635:640	arg1	source					642:647	carbon source	635:647	carbon source	635:647	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	4	61	attach	presented	1116:1124	arg2	sensor					1109:1114	the fabricated sensor	1094:1114	the fabricated sensor	1094:1114	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	4	61	attach	presented	1116:1124	arg1	range					1188:1192	the linear concentration range	1163:1192	the linear concentration range from 0.01 to 10 µM	1163:1211	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	1	62	theme	three-dimensional	239:255	arg1	carbon					277:282	three-dimensional hierarchical porous carbon	239:282	three-dimensional hierarchical porous carbon	239:282	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	4	63	theme	multi-functional	1003:1018	arg1	integration					1020:1030	the multi-functional integration	999:1030	the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan	999:1091	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	7	64	from	determination	1565:1577	arg1	samples					1602:1608	food samples	1597:1608	food samples	1597:1608	This work provides a very valuable reference for the sensitive determination of niclosamide in food samples.
34289441	1	65	theme	simple	150:155	arg1	strategy					189:196	a simple, low-cost, environment-friendly strategy	148:196	a simple, low-cost, environment-friendly strategy	148:196	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	6	66	theme	satisfactory	1477:1488	arg1	recoveries					1490:1499	satisfactory recoveries	1477:1499	satisfactory recoveries	1477:1499	Most important, the decent practicability for the detection of niclosamide was obtained in different food samples with low relative standard deviation and satisfactory recoveries.
34289441	1	67	theme	hierarchical	257:268	arg1	carbon					277:282	three-dimensional hierarchical porous carbon	239:282	three-dimensional hierarchical porous carbon	239:282	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	2	68	theme	functional	562:571	arg1	groups					573:578	self-generated oxygen-containing functional groups	529:578	self-generated oxygen-containing functional groups	529:578	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	3	69	theme	subsequent	736:745	arg1	process					758:764	the subsequent ultrasonic process	732:764	the subsequent ultrasonic process	732:764	During the subsequent ultrasonic process, chitosan with excellent filming property, strong adsorption ability, and good dispersibility was successfully decorated on the obtained porous carbon to further enhance the determination performance of niclosamide.
34289441	5	70	theme	fabricated	1228:1237	arg1	sensor					1239:1244	the fabricated sensor	1224:1244	the fabricated sensor	1224:1244	Moreover, the fabricated sensor could show good repeatability, reproducibility, stability, and selectivity.
34289441	1	71	theme	porous	270:275	arg1	carbon					277:282	three-dimensional hierarchical porous carbon	239:282	three-dimensional hierarchical porous carbon	239:282	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	0	72	theme	electrochemical	73:87	arg1	sensor					89:94	electrochemical sensor	73:94	electrochemical sensor	73:94	Three-dimensional hierarchical porous carbon coupled with chitosan based electrochemical sensor for sensitive determination of niclosamide.
34289441	5	73	theme	good	1257:1260	arg1	repeatability					1262:1274	good repeatability	1257:1274	good repeatability	1257:1274	Moreover, the fabricated sensor could show good repeatability, reproducibility, stability, and selectivity.
34289441	2	74	theme	interconnected	471:484	arg1	network					497:503	interconnected conductive network	471:503	interconnected conductive network	471:503	The three-dimensional porous carbon with interconnected conductive network, high surface area, and self-generated oxygen-containing functional groups was prepared by salt-templating method with glucose as carbon source and eutectic mixture of LiBr/KBr as both activating and pore-forming agent.
34289441	4	75	theme	chitosan	1084:1091	arg1	integration					1020:1030	the multi-functional integration	999:1030	the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan	999:1091	Benefitting from the multi-functional integration of three-dimensional hierarchical porous carbon and chitosan, the fabricated sensor presented a low limit of detection (6.7 nM) in the linear concentration range from 0.01 to 10 µM.
34289441	1	76	theme	carbon	277:282	arg1	chitosan					288:295	chitosan	288:295	chitosan	288:295	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	1	76	theme	carbon	277:282	arg1	carbon					277:282	three-dimensional hierarchical porous carbon	239:282	three-dimensional hierarchical porous carbon	239:282	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
34289441	1	76	theme	carbon	277:282	arg1	composite					226:234	the composite	222:234	the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide	222:427	Herein, a simple, low-cost, environment-friendly strategy was proposed to prepare the composite of three-dimensional hierarchical porous carbon and chitosan, which was applied to modify the glass carbon electrode to fabricate an electrochemical sensor for the determination of niclosamide.
32599485	8	0	theme	normal	1119:1124	arg1	model					1112:1116	PLS-R model	1106:1116	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1	1106:1183	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	8	0	theme	normal	1119:1124	arg1	spectra					1126:1132	normal spectra	1119:1132	normal spectra	1119:1132	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	9	1	theme	0.5	1425:1427	arg1	%					1428:1428	%	1428:1428	%	1428:1428	This method has a detection level of 0.5% w/v sucrose adulteration.
32599485	5	2	theme	Principal	674:682	arg1	PCA					704:706	PCA	704:706	PCA	704:706	Principal component analysis (PCA) was used for the discrimination of pure milk and adulterated milk.
32599485	5	2	theme	Principal	674:682	arg1	analysis					694:701	Principal component analysis	674:701	Principal component analysis (PCA)	674:707	Principal component analysis (PCA) was used for the discrimination of pure milk and adulterated milk.
32599485	2	3	theme	total	372:376	arg1	contents					384:391	the total solid contents	368:391	the total solid contents	368:391	Sucrose is illegally added in milk to reconstitute its compositional requirement by improving the total solid contents.
32599485	6	4	theme	%	901:901	arg1	efficiency					884:893	a classification efficiency	867:893	a classification efficiency of 100%	867:901	Soft independent modelling of class analogy (SIMCA) was able to classify test samples with a classification efficiency of 100%.
32599485	9	5	theme	w/v	1430:1432	arg1	adulteration					1442:1453	0.5% w/v sucrose adulteration	1425:1453	0.5% w/v sucrose adulteration	1425:1453	This method has a detection level of 0.5% w/v sucrose adulteration.
32599485	9	6	theme	adulteration	1442:1453	arg1	level					1416:1420	a detection level	1404:1420	a detection level of 0.5% w/v sucrose adulteration	1404:1453	This method has a detection level of 0.5% w/v sucrose adulteration.
32599485	6	7	theme	class	806:810	arg1	SIMCA					821:825	SIMCA	821:825	SIMCA	821:825	Soft independent modelling of class analogy (SIMCA) was able to classify test samples with a classification efficiency of 100%.
32599485	6	7	theme	class	806:810	arg1	analogy					812:818	class analogy	806:818	class analogy (SIMCA)	806:826	Soft independent modelling of class analogy (SIMCA) was able to classify test samples with a classification efficiency of 100%.
32599485	8	8	theme	wavenumber	1151:1160	arg1	range					1162:1166	the combined wavenumber range	1138:1166	the combined wavenumber range of 1070-980 cm-1	1138:1183	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	6	9	theme	classification	869:882	arg1	efficiency					884:893	a classification efficiency	867:893	a classification efficiency of 100%	867:901	Soft independent modelling of class analogy (SIMCA) was able to classify test samples with a classification efficiency of 100%.
32599485	1	10	theme	economic	211:218	arg1	benefit					220:226	economic benefit	211:226	economic benefit	211:226	Adulteration of milk to gain economic benefit has become a common practice in recent years.
32599485	4	11	theme	spectral	643:650	arg1	4000-400 cm-1					659:671	the spectral region 4000-400 cm-1	639:671	the spectral region 4000-400 cm-1	639:671	Pure milk and adulterated milk spectra (0.5-7.5% w/v) were observed in the spectral region 4000-400 cm-1.
32599485	3	12	theme	sucrose	547:553	arg1	quantification					529:542	quantification	529:542	quantification	529:542	The present study is aimed to use FTIR spectroscopy in combination with multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk.
32599485	3	12	theme	sucrose	547:553	arg1	differentiation					509:523	differentiation	509:523	differentiation	509:523	The present study is aimed to use FTIR spectroscopy in combination with multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk.
32599485	8	13	theme	%	1328:1328	arg1	w/v					1330:1332	0.20% w/v	1324:1332	Cal: 0.15% w/v; Val: 0.20% w/v	1303:1332	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	8	14	theme	determination	1252:1264	arg1	coefficient					1237:1247	coefficient	1237:1247	coefficient of determination (R2) (Cal: 0.996; Val: 0.993)	1237:1294	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	8	15	theme	best	1196:1199	arg1	prediction					1201:1210	the best prediction	1192:1210	the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993)	1192:1294	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	3	16	with	combination	449:459	arg1	modelling					491:499	multivariate chemometric modelling	466:499	multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk	466:565	The present study is aimed to use FTIR spectroscopy in combination with multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk.
32599485	7	17	theme	1st	1029:1031	arg1	spectra					1020:1026	normal spectra	1013:1026	normal spectra	1013:1026	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	7	17	theme	1st	1029:1031	arg1	derivative					1033:1042	1st derivative	1029:1042	1st derivative	1029:1042	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	7	18	theme	sucrose	1089:1095	arg1	quantification					1071:1084	the quantification	1067:1084	the quantification of sucrose in milk	1067:1103	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	8	19	theme	RE	1336:1337	arg1	%					1338:1338	RE%	1336:1338	RE% (Cal: 4.9% w/v; Val: 5.1% w/v)	1336:1369	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	8	19	theme	RE	1336:1337	arg1	w/v					1351:1353	Cal: 4.9% w/v	1341:1353	Cal: 4.9% w/v	1341:1353	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	1	20	from	practice	248:255	arg1	years					267:271	recent years	260:271	recent years	260:271	Adulteration of milk to gain economic benefit has become a common practice in recent years.
32599485	7	21	theme	PCR	980:982	arg1	models					985:990	principle component regression (PCR) models	948:990	principle component regression (PCR) models	948:990	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	5	22	theme	milk	770:773	arg1	discrimination					726:739	the discrimination	722:739	the discrimination of pure milk and adulterated milk	722:773	Principal component analysis (PCA) was used for the discrimination of pure milk and adulterated milk.
32599485	7	23	theme	regression	968:977	arg1	models					985:990	principle component regression (PCR) models	948:990	principle component regression (PCR) models	948:990	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	7	24	theme	principle	948:956	arg1	models					985:990	principle component regression (PCR) models	948:990	principle component regression (PCR) models	948:990	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	8	25	theme	%	1349:1349	arg1	%					1338:1338	RE%	1336:1338	RE% (Cal: 4.9% w/v; Val: 5.1% w/v)	1336:1369	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	8	25	theme	%	1349:1349	arg1	w/v					1351:1353	Cal: 4.9% w/v	1341:1353	Cal: 4.9% w/v	1341:1353	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	0	26	theme	total	88:92	arg1	reflectance-Fourier					94:112	Attenuated total reflectance-Fourier	77:112	Attenuated total reflectance-Fourier	77:112	Rapid detection and quantification of sucrose adulteration in cow milk using Attenuated total reflectance-Fourier transform infrared spectroscopy coupled with multivariate analysis.
32599485	3	27	dep	differentiation	509:523	arg1	the					505:507	the	505:507	the	505:507	The present study is aimed to use FTIR spectroscopy in combination with multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk.
32599485	0	28	theme	Rapid	0:4	arg1	detection					6:14	detection	6:14	detection	6:14	Rapid detection and quantification of sucrose adulteration in cow milk using Attenuated total reflectance-Fourier transform infrared spectroscopy coupled with multivariate analysis.
32599485	7	29	theme	square	918:923	arg1	PLS-R					937:941	PLS-R	937:941	PLS-R	937:941	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	7	29	theme	square	918:923	arg1	regression					925:934	Partial least square regression	904:934	Partial least square regression (PLS-R)	904:942	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	8	30	theme	%	1364:1364	arg1	w/v					1366:1368	Val: 5.1% w/v	1356:1368	Val: 5.1% w/v	1356:1368	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	4	31	theme	milk	594:597	arg1	spectra					599:605	adulterated milk spectra	582:605	adulterated milk spectra	582:605	Pure milk and adulterated milk spectra (0.5-7.5% w/v) were observed in the spectral region 4000-400 cm-1.
32599485	8	32	theme	0.15	1308:1311	arg1	w/v					1314:1316	0.15% w/v	1308:1316	Cal: 0.15% w/v; Val: 0.20% w/v	1303:1332	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	3	33	theme	multivariate	466:477	arg1	modelling					491:499	multivariate chemometric modelling	466:499	multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk	466:565	The present study is aimed to use FTIR spectroscopy in combination with multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk.
32599485	8	34	dep	Cal	1303:1305	arg1	Val					1319:1321	Val	1319:1321	Cal: 0.15% w/v; Val: 0.20% w/v	1303:1332	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	8	34	dep	Cal	1303:1305	arg1	w/v					1314:1316	0.15% w/v	1308:1316	Cal: 0.15% w/v; Val: 0.20% w/v	1303:1332	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	8	34	dep	Cal	1303:1305	arg1	w/v					1330:1332	0.20% w/v	1324:1332	Cal: 0.15% w/v; Val: 0.20% w/v	1303:1332	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	8	35	from	model	1112:1116	arg1	range					1162:1166	the combined wavenumber range	1138:1166	the combined wavenumber range of 1070-980 cm-1	1138:1183	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	0	36	theme	cow	62:64	arg1	milk					66:69	cow milk	62:69	cow milk using Attenuated total reflectance-Fourier	62:112	Rapid detection and quantification of sucrose adulteration in cow milk using Attenuated total reflectance-Fourier transform infrared spectroscopy coupled with multivariate analysis.
32599485	4	37	located	observed	627:634	arg2	spectra					599:605	adulterated milk spectra	582:605	adulterated milk spectra	582:605	Pure milk and adulterated milk spectra (0.5-7.5% w/v) were observed in the spectral region 4000-400 cm-1.
32599485	4	37	located	observed	627:634	arg2	w/v					617:619	0.5-7.5% w/v	608:619	0.5-7.5% w/v	608:619	Pure milk and adulterated milk spectra (0.5-7.5% w/v) were observed in the spectral region 4000-400 cm-1.
32599485	4	37	located	observed	627:634	arg1	4000-400 cm-1					659:671	the spectral region 4000-400 cm-1	639:671	the spectral region 4000-400 cm-1	639:671	Pure milk and adulterated milk spectra (0.5-7.5% w/v) were observed in the spectral region 4000-400 cm-1.
32599485	4	37	located	observed	627:634	arg2	milk					573:576	Pure milk	568:576	Pure milk	568:576	Pure milk and adulterated milk spectra (0.5-7.5% w/v) were observed in the spectral region 4000-400 cm-1.
32599485	0	38	theme	adulteration	46:57	arg1	quantification					20:33	quantification	20:33	quantification	20:33	Rapid detection and quantification of sucrose adulteration in cow milk using Attenuated total reflectance-Fourier transform infrared spectroscopy coupled with multivariate analysis.
32599485	0	38	theme	adulteration	46:57	arg1	detection					6:14	detection	6:14	detection	6:14	Rapid detection and quantification of sucrose adulteration in cow milk using Attenuated total reflectance-Fourier transform infrared spectroscopy coupled with multivariate analysis.
32599485	8	39	dep	Cal	1272:1274	arg1	0.993					1289:1293	0.993	1289:1293	0.993	1289:1293	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	8	39	dep	Cal	1272:1274	arg1	Val					1284:1286	Val	1284:1286	Cal: 0.996; Val: 0.993	1272:1293	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	8	39	dep	Cal	1272:1274	arg1	0.996					1277:1281	0.996	1277:1281	0.996	1277:1281	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	4	40	theme	Pure	568:571	arg1	w/v					617:619	0.5-7.5% w/v	608:619	0.5-7.5% w/v	608:619	Pure milk and adulterated milk spectra (0.5-7.5% w/v) were observed in the spectral region 4000-400 cm-1.
32599485	4	40	theme	Pure	568:571	arg1	milk					573:576	Pure milk	568:576	Pure milk	568:576	Pure milk and adulterated milk spectra (0.5-7.5% w/v) were observed in the spectral region 4000-400 cm-1.
32599485	7	41	theme	least	912:916	arg1	PLS-R					937:941	PLS-R	937:941	PLS-R	937:941	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	7	41	theme	least	912:916	arg1	regression					925:934	Partial least square regression	904:934	Partial least square regression (PLS-R)	904:942	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	1	42	theme	common	241:246	arg1	practice					248:255	a common practice	239:255	a common practice in recent years	239:271	Adulteration of milk to gain economic benefit has become a common practice in recent years.
32599485	9	43	theme	detection	1406:1414	arg1	level					1416:1420	a detection level	1404:1420	a detection level of 0.5% w/v sucrose adulteration	1404:1453	This method has a detection level of 0.5% w/v sucrose adulteration.
32599485	8	44	theme	PLS-R	1106:1110	arg1	model					1112:1116	PLS-R model	1106:1116	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1	1106:1183	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	8	44	theme	PLS-R	1106:1110	arg1	spectra					1126:1132	normal spectra	1119:1132	normal spectra	1119:1132	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	2	45	theme	solid	378:382	arg1	contents					384:391	the total solid contents	368:391	the total solid contents	368:391	Sucrose is illegally added in milk to reconstitute its compositional requirement by improving the total solid contents.
32599485	8	46	dep	w/v	1351:1353	arg1	w/v					1366:1368	Val: 5.1% w/v	1356:1368	Val: 5.1% w/v	1356:1368	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	9	47	theme	%	1428:1428	arg1	adulteration					1442:1453	0.5% w/v sucrose adulteration	1425:1453	0.5% w/v sucrose adulteration	1425:1453	This method has a detection level of 0.5% w/v sucrose adulteration.
32599485	5	48	theme	component	684:692	arg1	PCA					704:706	PCA	704:706	PCA	704:706	Principal component analysis (PCA) was used for the discrimination of pure milk and adulterated milk.
32599485	5	48	theme	component	684:692	arg1	analysis					694:701	Principal component analysis	674:701	Principal component analysis (PCA)	674:707	Principal component analysis (PCA) was used for the discrimination of pure milk and adulterated milk.
32599485	9	49	theme	sucrose	1434:1440	arg1	adulteration					1442:1453	0.5% w/v sucrose adulteration	1425:1453	0.5% w/v sucrose adulteration	1425:1453	This method has a detection level of 0.5% w/v sucrose adulteration.
32599485	4	50	theme	%	615:615	arg1	milk					573:576	Pure milk	568:576	Pure milk	568:576	Pure milk and adulterated milk spectra (0.5-7.5% w/v) were observed in the spectral region 4000-400 cm-1.
32599485	4	50	theme	%	615:615	arg1	w/v					617:619	0.5-7.5% w/v	608:619	0.5-7.5% w/v	608:619	Pure milk and adulterated milk spectra (0.5-7.5% w/v) were observed in the spectral region 4000-400 cm-1.
32599485	6	51	theme	analogy	812:818	arg1	modelling					793:801	Soft independent modelling	776:801	Soft independent modelling of class analogy (SIMCA)	776:826	Soft independent modelling of class analogy (SIMCA) was able to classify test samples with a classification efficiency of 100%.
32599485	1	52	theme	milk	198:201	arg1	Adulteration					182:193	Adulteration	182:193	Adulteration of milk to gain economic benefit	182:226	Adulteration of milk to gain economic benefit has become a common practice in recent years.
32599485	9	53	contain	has	1400:1402	arg1	method					1393:1398	This method	1388:1398	This method	1388:1398	This method has a detection level of 0.5% w/v sucrose adulteration.
32599485	9	53	contain	has	1400:1402	arg2	level					1416:1420	a detection level	1404:1420	a detection level of 0.5% w/v sucrose adulteration	1404:1453	This method has a detection level of 0.5% w/v sucrose adulteration.
32599485	3	54	from	differentiation	509:523	arg1	milk					562:565	cow milk	558:565	cow milk	558:565	The present study is aimed to use FTIR spectroscopy in combination with multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk.
32599485	2	55	theme	compositional	329:341	arg1	requirement					343:353	its compositional requirement	325:353	its compositional requirement	325:353	Sucrose is illegally added in milk to reconstitute its compositional requirement by improving the total solid contents.
32599485	8	56	dep	RMSE	1297:1300	arg1	Cal					1303:1305	Cal	1303:1305	Cal: 0.15% w/v; Val: 0.20% w/v	1303:1332	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	8	57	theme	combined	1142:1149	arg1	range					1162:1166	the combined wavenumber range	1138:1166	the combined wavenumber range of 1070-980 cm-1	1138:1183	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	7	58	theme	2nd	1048:1050	arg1	spectra					1020:1026	normal spectra	1013:1026	normal spectra	1013:1026	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	7	58	theme	2nd	1048:1050	arg1	derivative					1052:1061	2nd derivative	1048:1061	2nd derivative	1048:1061	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	3	59	from	quantification	529:542	arg1	milk					562:565	cow milk	558:565	cow milk	558:565	The present study is aimed to use FTIR spectroscopy in combination with multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk.
32599485	0	60	theme	multivariate	159:170	arg1	analysis					172:179	multivariate analysis	159:179	multivariate analysis	159:179	Rapid detection and quantification of sucrose adulteration in cow milk using Attenuated total reflectance-Fourier transform infrared spectroscopy coupled with multivariate analysis.
32599485	8	61	theme	1070-980 cm-1	1171:1183	arg1	range					1162:1166	the combined wavenumber range	1138:1166	the combined wavenumber range of 1070-980 cm-1	1138:1183	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	4	62	theme	region	652:657	arg1	4000-400 cm-1					659:671	the spectral region 4000-400 cm-1	639:671	the spectral region 4000-400 cm-1	639:671	Pure milk and adulterated milk spectra (0.5-7.5% w/v) were observed in the spectral region 4000-400 cm-1.
32599485	5	63	used	used	713:716	arg2	analysis					694:701	Principal component analysis	674:701	Principal component analysis (PCA)	674:707	Principal component analysis (PCA) was used for the discrimination of pure milk and adulterated milk.
32599485	5	63	used	used	713:716	arg2	PCA					704:706	PCA	704:706	PCA	704:706	Principal component analysis (PCA) was used for the discrimination of pure milk and adulterated milk.
32599485	6	64	theme	independent	781:791	arg1	modelling					793:801	Soft independent modelling	776:801	Soft independent modelling of class analogy (SIMCA)	776:826	Soft independent modelling of class analogy (SIMCA) was able to classify test samples with a classification efficiency of 100%.
32599485	7	65	theme	normal	1013:1018	arg1	spectra					1020:1026	normal spectra	1013:1026	normal spectra	1013:1026	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	7	65	theme	normal	1013:1018	arg1	derivative					1033:1042	1st derivative	1029:1042	1st derivative	1029:1042	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	7	65	theme	normal	1013:1018	arg1	derivative					1052:1061	2nd derivative	1048:1061	2nd derivative	1048:1061	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	8	66	theme	Cal	1341:1343	arg1	%					1338:1338	RE%	1336:1338	RE% (Cal: 4.9% w/v; Val: 5.1% w/v)	1336:1369	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	8	66	theme	Cal	1341:1343	arg1	w/v					1351:1353	Cal: 4.9% w/v	1341:1353	Cal: 4.9% w/v	1341:1353	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	5	67	theme	adulterated	758:768	arg1	milk					770:773	adulterated milk	758:773	adulterated milk	758:773	Principal component analysis (PCA) was used for the discrimination of pure milk and adulterated milk.
32599485	0	68	from	quantification	20:33	arg1	milk					66:69	cow milk	62:69	cow milk using Attenuated total reflectance-Fourier	62:112	Rapid detection and quantification of sucrose adulteration in cow milk using Attenuated total reflectance-Fourier transform infrared spectroscopy coupled with multivariate analysis.
32599485	5	69	theme	pure	744:747	arg1	milk					749:752	pure milk	744:752	pure milk	744:752	Principal component analysis (PCA) was used for the discrimination of pure milk and adulterated milk.
32599485	0	70	theme	Attenuated	77:86	arg1	reflectance-Fourier					94:112	Attenuated total reflectance-Fourier	77:112	Attenuated total reflectance-Fourier	77:112	Rapid detection and quantification of sucrose adulteration in cow milk using Attenuated total reflectance-Fourier transform infrared spectroscopy coupled with multivariate analysis.
32599485	0	71	from	detection	6:14	arg1	milk					66:69	cow milk	62:69	cow milk using Attenuated total reflectance-Fourier	62:112	Rapid detection and quantification of sucrose adulteration in cow milk using Attenuated total reflectance-Fourier transform infrared spectroscopy coupled with multivariate analysis.
32599485	7	72	theme	component	958:966	arg1	models					985:990	principle component regression (PCR) models	948:990	principle component regression (PCR) models	948:990	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	8	73	theme	Val	1356:1358	arg1	w/v					1366:1368	Val: 5.1% w/v	1356:1368	Val: 5.1% w/v	1356:1368	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	0	74	theme	infrared	124:131	arg1	spectroscopy					133:144	infrared spectroscopy	124:144	infrared spectroscopy coupled with multivariate analysis	124:179	Rapid detection and quantification of sucrose adulteration in cow milk using Attenuated total reflectance-Fourier transform infrared spectroscopy coupled with multivariate analysis.
32599485	8	75	dep	coefficient	1237:1247	arg1	Cal					1272:1274	Cal	1272:1274	Cal: 0.996; Val: 0.993	1272:1293	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	5	76	theme	milk	749:752	arg1	discrimination					726:739	the discrimination	722:739	the discrimination of pure milk and adulterated milk	722:773	Principal component analysis (PCA) was used for the discrimination of pure milk and adulterated milk.
32599485	4	77	theme	adulterated	582:592	arg1	spectra					599:605	adulterated milk spectra	582:605	adulterated milk spectra	582:605	Pure milk and adulterated milk spectra (0.5-7.5% w/v) were observed in the spectral region 4000-400 cm-1.
32599485	3	78	theme	present	398:404	arg1	study					406:410	The present study	394:410	The present study	394:410	The present study is aimed to use FTIR spectroscopy in combination with multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk.
32599485	7	79	from	quantification	1071:1084	arg1	milk					1100:1103	milk	1100:1103	milk	1100:1103	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	0	80	theme	sucrose	38:44	arg1	adulteration					46:57	sucrose adulteration	38:57	sucrose adulteration	38:57	Rapid detection and quantification of sucrose adulteration in cow milk using Attenuated total reflectance-Fourier transform infrared spectroscopy coupled with multivariate analysis.
32599485	3	81	theme	FTIR	428:431	arg1	spectroscopy					433:444	FTIR spectroscopy	428:444	FTIR spectroscopy	428:444	The present study is aimed to use FTIR spectroscopy in combination with multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk.
32599485	7	82	from	sucrose	1089:1095	arg1	milk					1100:1103	milk	1100:1103	milk	1100:1103	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	6	83	theme	Soft	776:779	arg1	modelling					793:801	Soft independent modelling	776:801	Soft independent modelling of class analogy (SIMCA)	776:826	Soft independent modelling of class analogy (SIMCA) was able to classify test samples with a classification efficiency of 100%.
32599485	3	84	theme	chemometric	479:489	arg1	modelling					491:499	multivariate chemometric modelling	466:499	multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk	466:565	The present study is aimed to use FTIR spectroscopy in combination with multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk.
32599485	6	85	theme	test	849:852	arg1	samples					854:860	test samples	849:860	test samples	849:860	Soft independent modelling of class analogy (SIMCA) was able to classify test samples with a classification efficiency of 100%.
32599485	7	86	from	milk	1100:1103	arg1	quantification					1071:1084	the quantification	1067:1084	the quantification of sucrose in milk	1067:1103	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	8	87	theme	%	1312:1312	arg1	w/v					1314:1316	0.15% w/v	1308:1316	Cal: 0.15% w/v; Val: 0.20% w/v	1303:1332	PLS-R model (normal spectra) in the combined wavenumber range of 1070-980 cm-1 showed the best prediction based on parameters like coefficient of determination (R2) (Cal: 0.996; Val: 0.993), RMSE (Cal: 0.15% w/v; Val: 0.20% w/v), RE% (Cal: 4.9% w/v; Val: 5.1% w/v) and RPD (13.40).
32599485	7	88	theme	Partial	904:910	arg1	PLS-R					937:941	PLS-R	937:941	PLS-R	937:941	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	7	88	theme	Partial	904:910	arg1	regression					925:934	Partial least square regression	904:934	Partial least square regression (PLS-R)	904:942	Partial least square regression (PLS-R) and principle component regression (PCR) models were established for normal spectra, 1st derivative and 2nd derivative for the quantification of sucrose in milk.
32599485	3	89	theme	cow	558:560	arg1	milk					562:565	cow milk	558:565	cow milk	558:565	The present study is aimed to use FTIR spectroscopy in combination with multivariate chemometric modelling for the differentiation and quantification of sucrose in cow milk.
32599485	1	90	theme	recent	260:265	arg1	years					267:271	recent years	260:271	recent years	260:271	Adulteration of milk to gain economic benefit has become a common practice in recent years.
31985373	12	0	theme	microspheres	1751:1762	arg1	roughness					1707:1715	the roughness	1703:1715	the roughness of sodium alginate/water hyacinth microspheres	1703:1762	SEM indicated further deformation in the morphology with the roughness of sodium alginate/water hyacinth microspheres, while FTIR confirmed the uniform matrices of the microspheres.
31985373	3	1	theme	green	501:505	arg1	route					507:511	a cost-effective green route	484:511	a cost-effective green route through composites of sodium alginate and dried water hyacinth	484:574	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	9	2	theme	hydrogen	1358:1365	arg1	bonds					1367:1371	hydrogen bonds	1358:1371	hydrogen bonds	1358:1371	RESULTS Molecular modeling indicated that the blending of such structures enhances their ability to bind with surrounding molecules owing to their ability to form hydrogen bonds.
31985373	4	3	from	B3LYP/6-31g	621:631	arg1	modeling					609:616	MATERIALS AND METHODS Molecular modeling	577:616	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p)	577:636	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p) was utilized to study sodium alginate, cellulose and chitosan.
31985373	1	4	theme	environmental	156:168	arg1	impact					183:188	a great environmental and economic impact	148:188	a great environmental and economic impact	148:188	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	12	5	dep	indicated	1650:1658	arg1	while					1765:1769	while	1765:1769	while	1765:1769	SEM indicated further deformation in the morphology with the roughness of sodium alginate/water hyacinth microspheres, while FTIR confirmed the uniform matrices of the microspheres.
31985373	1	6	theme	economic	174:181	arg1	impact					183:188	a great environmental and economic impact	148:188	a great environmental and economic impact	148:188	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	8	7	theme	Atomic	1128:1133	arg1	spectroscopy					1146:1157	Atomic absorption spectroscopy	1128:1157	Atomic absorption spectroscopy	1128:1157	Atomic absorption spectroscopy was used to study the levels of Pb.
31985373	6	8	theme	plant	921:925	arg1	water					927:931	the aquatic plant water hyacinth	909:940	the aquatic plant water hyacinth in dry form	909:952	The roots of the aquatic plant water hyacinth in dry form were added to the cross-linked sodium alginate for up to 70%.
31985373	8	9	theme	Pb	1191:1192	arg1	levels					1181:1186	the levels	1177:1186	the levels of Pb	1177:1192	Atomic absorption spectroscopy was used to study the levels of Pb.
31985373	10	10	theme	proper	1521:1526	arg1	formation					1528:1536	the proper formation	1517:1536	the proper formation of the desired blends	1517:1558	SEM results indicated that homogeneous structures of cellulose and chitosan are deformed when blended with sodium alginate, and FTIR confirmed the proper formation of the desired blends.
31985373	2	11	theme	sources	280:286	arg1	pollutants					256:265	pollutants	256:265	pollutants of different sources from wastewater	256:302	Therefore, it is crucial to innovate different methods to remove pollutants of different sources from wastewater.
31985373	3	12	theme	dried	555:559	arg1	water					561:565	dried water hyacinth	555:574	dried water hyacinth	555:574	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	5	13	theme	sodium	788:793	arg1	50/50					868:872	50/50	868:872	50/50	868:872	Sodium alginate was cross-linked with calcium chloride to form microspheres, then both sodium alginate/cellulose and sodium alginate/chitosan were also crosslinked as 50/50 to form microspheres.
31985373	5	13	theme	sodium	788:793	arg1	alginate/cellulose					795:812	sodium alginate/cellulose	788:812	sodium alginate/cellulose	788:812	Sodium alginate was cross-linked with calcium chloride to form microspheres, then both sodium alginate/cellulose and sodium alginate/chitosan were also crosslinked as 50/50 to form microspheres.
31985373	5	13	theme	sodium	788:793	arg1	alginate/chitosan					825:841	sodium alginate/chitosan	818:841	sodium alginate/chitosan	818:841	Sodium alginate was cross-linked with calcium chloride to form microspheres, then both sodium alginate/cellulose and sodium alginate/chitosan were also crosslinked as 50/50 to form microspheres.
31985373	10	14	theme	desired	1545:1551	arg1	blends					1553:1558	the desired blends	1541:1558	the desired blends	1541:1558	SEM results indicated that homogeneous structures of cellulose and chitosan are deformed when blended with sodium alginate, and FTIR confirmed the proper formation of the desired blends.
31985373	3	15	theme	alginate	542:549	arg1	composites					521:530	composites	521:530	composites of sodium alginate and dried water hyacinth	521:574	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	15	theme	alginate	542:549	arg1	alginate					542:549	sodium alginate	535:549	sodium alginate	535:549	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	15	theme	alginate	542:549	arg1	water					561:565	dried water hyacinth	555:574	dried water hyacinth	555:574	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	2	16	from	pollutants	256:265	arg1	wastewater					293:302	wastewater	293:302	wastewater	293:302	Therefore, it is crucial to innovate different methods to remove pollutants of different sources from wastewater.
31985373	4	17	theme	sodium	660:665	arg1	cellulose					677:685	cellulose	677:685	cellulose	677:685	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p) was utilized to study sodium alginate, cellulose and chitosan.
31985373	4	17	theme	sodium	660:665	arg1	alginate					667:674	sodium alginate	660:674	sodium alginate	660:674	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p) was utilized to study sodium alginate, cellulose and chitosan.
31985373	4	17	theme	sodium	660:665	arg1	chitosan					691:698	chitosan	691:698	chitosan	691:698	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p) was utilized to study sodium alginate, cellulose and chitosan.
31985373	3	18	theme	cost-effective	486:499	arg1	route					507:511	a cost-effective green route	484:511	a cost-effective green route through composites of sodium alginate and dried water hyacinth	484:574	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	1	19	theme	important	121:129	arg1	AIM					60:62	AIM	60:62	AIM	60:62	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	1	19	theme	important	121:129	arg1	process					131:137	a very important process	114:137	a very important process that has a great environmental and economic impact	114:188	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	1	19	theme	important	121:129	arg1	treatment/remediation					89:109	OBJECTIVE Wastewater treatment/remediation	68:109	OBJECTIVE Wastewater treatment/remediation	68:109	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	0	20	theme	Aquatic	39:45	arg1	Environment					47:57	Aquatic Environment	39:57	Aquatic Environment	39:57	Green Route for the Removal of Pb from Aquatic Environment.
31985373	9	21	theme	Molecular	1203:1211	arg1	modeling					1213:1220	Molecular modeling	1203:1220	Molecular modeling	1203:1220	RESULTS Molecular modeling indicated that the blending of such structures enhances their ability to bind with surrounding molecules owing to their ability to form hydrogen bonds.
31985373	12	22	with	morphology	1687:1696	arg1	roughness					1707:1715	the roughness	1703:1715	the roughness of sodium alginate/water hyacinth microspheres	1703:1762	SEM indicated further deformation in the morphology with the roughness of sodium alginate/water hyacinth microspheres, while FTIR confirmed the uniform matrices of the microspheres.
31985373	13	23	theme	Pb+2	1843:1846	arg1	removal					1832:1838	The removal	1828:1838	The removal of Pb+2	1828:1846	The removal of Pb+2 was enhanced because of the addition of dried water hyacinth's roots.
31985373	6	24	theme	dry	945:947	arg1	form					949:952	dry form	945:952	dry form	945:952	The roots of the aquatic plant water hyacinth in dry form were added to the cross-linked sodium alginate for up to 70%.
31985373	4	25	used	utilized	642:649	arg2	B3LYP/6-31g					621:631	B3LYP/6-31g	621:631	B3LYP/6-31g(d,p)	621:636	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p) was utilized to study sodium alginate, cellulose and chitosan.
31985373	4	25	used	utilized	642:649	arg2	modeling					609:616	MATERIALS AND METHODS Molecular modeling	577:616	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p)	577:636	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p) was utilized to study sodium alginate, cellulose and chitosan.
31985373	14	26	theme	green	2020:2024	arg1	root					2010:2013	sodium alginate/water hyacinth root	1979:2013	sodium alginate/water hyacinth root	1979:2013	CONCLUSION Modeling, experimental and kinetic data highlight sodium alginate/water hyacinth root as a green route to remediate Pb+2 from wastewater.
31985373	14	26	theme	green	2020:2024	arg1	route					2026:2030	a green route	2018:2030	a green route to remediate Pb+2 from wastewater	2018:2064	CONCLUSION Modeling, experimental and kinetic data highlight sodium alginate/water hyacinth root as a green route to remediate Pb+2 from wastewater.
31985373	14	27	theme	kinetic	1956:1962	arg1	data					1964:1967	experimental and kinetic data	1939:1967	data	1964:1967	CONCLUSION Modeling, experimental and kinetic data highlight sodium alginate/water hyacinth root as a green route to remediate Pb+2 from wastewater.
31985373	6	28	from	form	949:952	arg1	roots					900:904	The roots	896:904	The roots of the aquatic plant water hyacinth in dry form	896:952	The roots of the aquatic plant water hyacinth in dry form were added to the cross-linked sodium alginate for up to 70%.
31985373	6	29	link	cross-linked	972:983	arg1	alginate					992:999	the cross-linked sodium alginate	968:999	the cross-linked sodium alginate for up to 70%	968:1013	The roots of the aquatic plant water hyacinth in dry form were added to the cross-linked sodium alginate for up to 70%.
31985373	6	30	from	water	927:931	arg1	form					949:952	dry form	945:952	dry form	945:952	The roots of the aquatic plant water hyacinth in dry form were added to the cross-linked sodium alginate for up to 70%.
31985373	9	31	theme	structures	1258:1267	arg1	blending					1241:1248	the blending	1237:1248	the blending of such structures	1237:1267	RESULTS Molecular modeling indicated that the blending of such structures enhances their ability to bind with surrounding molecules owing to their ability to form hydrogen bonds.
31985373	1	32	theme	OBJECTIVE	68:76	arg1	AIM					60:62	AIM	60:62	AIM	60:62	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	1	32	theme	OBJECTIVE	68:76	arg1	process					131:137	a very important process	114:137	a very important process that has a great environmental and economic impact	114:188	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	1	32	theme	OBJECTIVE	68:76	arg1	treatment/remediation					89:109	OBJECTIVE Wastewater treatment/remediation	68:109	OBJECTIVE Wastewater treatment/remediation	68:109	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	2	33	theme	different	228:236	arg1	methods					238:244	different methods	228:244	different methods	228:244	Therefore, it is crucial to innovate different methods to remove pollutants of different sources from wastewater.
31985373	10	34	theme	chitosan	1441:1448	arg1	structures					1413:1422	homogeneous structures	1401:1422	homogeneous structures of cellulose and chitosan	1401:1448	SEM results indicated that homogeneous structures of cellulose and chitosan are deformed when blended with sodium alginate, and FTIR confirmed the proper formation of the desired blends.
31985373	3	35	theme	sodium	426:431	arg1	alginate					433:440	sodium alginate	426:440	sodium alginate	426:440	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	7	36	theme	microspheres	1080:1091	arg1	surface					1056:1062	the surface	1052:1062	the surface of the prepared microspheres and their structures	1052:1112	SEM and FTIR were employed to study the surface of the prepared microspheres and their structures respectively.
31985373	12	37	theme	microspheres	1814:1825	arg1	matrices					1798:1805	the uniform matrices	1786:1805	the uniform matrices of the microspheres	1786:1825	SEM indicated further deformation in the morphology with the roughness of sodium alginate/water hyacinth microspheres, while FTIR confirmed the uniform matrices of the microspheres.
31985373	10	38	theme	cellulose	1427:1435	arg1	structures					1413:1422	homogeneous structures	1401:1422	homogeneous structures of cellulose and chitosan	1401:1448	SEM results indicated that homogeneous structures of cellulose and chitosan are deformed when blended with sodium alginate, and FTIR confirmed the proper formation of the desired blends.
31985373	3	39	theme	composites	412:421	arg1	microspheres					396:407	microspheres	396:407	microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth	396:574	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	6	40	theme	cross-linked	972:983	arg1	alginate					992:999	the cross-linked sodium alginate	968:999	the cross-linked sodium alginate for up to 70%	968:1013	The roots of the aquatic plant water hyacinth in dry form were added to the cross-linked sodium alginate for up to 70%.
31985373	11	41	from	alginate	1586:1593	arg1	Microspheres					1561:1572	Microspheres	1561:1572	Microspheres from sodium alginate	1561:1593	Microspheres from sodium alginate showed the ability to remove Pb+2 from wastewater.
31985373	5	42	theme	calcium	739:745	arg1	chloride					747:754	calcium chloride	739:754	calcium chloride	739:754	Sodium alginate was cross-linked with calcium chloride to form microspheres, then both sodium alginate/cellulose and sodium alginate/chitosan were also crosslinked as 50/50 to form microspheres.
31985373	12	43	theme	uniform	1790:1796	arg1	matrices					1798:1805	the uniform matrices	1786:1805	the uniform matrices of the microspheres	1786:1825	SEM indicated further deformation in the morphology with the roughness of sodium alginate/water hyacinth microspheres, while FTIR confirmed the uniform matrices of the microspheres.
31985373	10	44	theme	sodium	1481:1486	arg1	alginate					1488:1495	sodium alginate	1481:1495	sodium alginate	1481:1495	SEM results indicated that homogeneous structures of cellulose and chitosan are deformed when blended with sodium alginate, and FTIR confirmed the proper formation of the desired blends.
31985373	9	45	dep	RESULTS	1195:1201	arg1	indicated					1222:1230	indicated	1222:1230	indicated that the blending of such structures enhances their ability to bind with surrounding molecules owing to their ability to form hydrogen bonds	1222:1371	RESULTS Molecular modeling indicated that the blending of such structures enhances their ability to bind with surrounding molecules owing to their ability to form hydrogen bonds.
31985373	11	46	theme	sodium	1579:1584	arg1	alginate					1586:1593	sodium alginate	1579:1593	sodium alginate	1579:1593	Microspheres from sodium alginate showed the ability to remove Pb+2 from wastewater.
31985373	14	47	theme	experimental	1939:1950	arg1	data					1964:1967	experimental and kinetic data	1939:1967	data	1964:1967	CONCLUSION Modeling, experimental and kinetic data highlight sodium alginate/water hyacinth root as a green route to remediate Pb+2 from wastewater.
31985373	2	48	theme	different	270:278	arg1	sources					280:286	different sources	270:286	different sources from wastewater	270:302	Therefore, it is crucial to innovate different methods to remove pollutants of different sources from wastewater.
31985373	12	49	theme	sodium	1720:1725	arg1	microspheres					1751:1762	sodium alginate/water hyacinth microspheres	1720:1762	sodium alginate/water hyacinth microspheres	1720:1762	SEM indicated further deformation in the morphology with the roughness of sodium alginate/water hyacinth microspheres, while FTIR confirmed the uniform matrices of the microspheres.
31985373	1	50	contain	has	144:146	arg1	AIM					60:62	AIM	60:62	AIM	60:62	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	1	50	contain	has	144:146	arg2	impact					183:188	a great environmental and economic impact	148:188	a great environmental and economic impact	148:188	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	1	50	contain	has	144:146	arg1	process					131:137	a very important process	114:137	a very important process that has a great environmental and economic impact	114:188	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	1	50	contain	has	144:146	arg1	treatment/remediation					89:109	OBJECTIVE Wastewater treatment/remediation	68:109	OBJECTIVE Wastewater treatment/remediation	68:109	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	1	51	theme	great	150:154	arg1	impact					183:188	a great environmental and economic impact	148:188	a great environmental and economic impact	148:188	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	0	52	theme	Pb	31:32	arg1	Removal					20:26	the Removal	16:26	the Removal of Pb from Aquatic Environment	16:57	Green Route for the Removal of Pb from Aquatic Environment.
31985373	13	53	theme	dried	1888:1892	arg1	roots					1911:1915	dried water hyacinth's roots	1888:1915	dried water hyacinth's roots	1888:1915	The removal of Pb+2 was enhanced because of the addition of dried water hyacinth's roots.
31985373	5	54	theme	sodium	818:823	arg1	alginate/cellulose					795:812	sodium alginate/cellulose	788:812	sodium alginate/cellulose	788:812	Sodium alginate was cross-linked with calcium chloride to form microspheres, then both sodium alginate/cellulose and sodium alginate/chitosan were also crosslinked as 50/50 to form microspheres.
31985373	5	54	theme	sodium	818:823	arg1	50/50					868:872	50/50	868:872	50/50	868:872	Sodium alginate was cross-linked with calcium chloride to form microspheres, then both sodium alginate/cellulose and sodium alginate/chitosan were also crosslinked as 50/50 to form microspheres.
31985373	5	54	theme	sodium	818:823	arg1	alginate/chitosan					825:841	sodium alginate/chitosan	818:841	sodium alginate/chitosan	818:841	Sodium alginate was cross-linked with calcium chloride to form microspheres, then both sodium alginate/cellulose and sodium alginate/chitosan were also crosslinked as 50/50 to form microspheres.
31985373	6	55	theme	water	927:931	arg1	roots					900:904	The roots	896:904	The roots of the aquatic plant water hyacinth in dry form	896:952	The roots of the aquatic plant water hyacinth in dry form were added to the cross-linked sodium alginate for up to 70%.
31985373	13	56	theme	water	1894:1898	arg1	roots					1911:1915	dried water hyacinth's roots	1888:1915	dried water hyacinth's roots	1888:1915	The removal of Pb+2 was enhanced because of the addition of dried water hyacinth's roots.
31985373	6	57	theme	aquatic	913:919	arg1	water					927:931	the aquatic plant water hyacinth	909:940	the aquatic plant water hyacinth in dry form	909:952	The roots of the aquatic plant water hyacinth in dry form were added to the cross-linked sodium alginate for up to 70%.
31985373	8	58	theme	absorption	1135:1144	arg1	spectroscopy					1146:1157	Atomic absorption spectroscopy	1128:1157	Atomic absorption spectroscopy	1128:1157	Atomic absorption spectroscopy was used to study the levels of Pb.
31985373	0	59	from	Environment	47:57	arg1	Removal					20:26	the Removal	16:26	the Removal of Pb from Aquatic Environment	16:57	Green Route for the Removal of Pb from Aquatic Environment.
31985373	4	60	theme	Molecular	599:607	arg1	modeling					609:616	MATERIALS AND METHODS Molecular modeling	577:616	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p)	577:636	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p) was utilized to study sodium alginate, cellulose and chitosan.
31985373	10	61	theme	blends	1553:1558	arg1	formation					1528:1536	the proper formation	1517:1536	the proper formation of the desired blends	1517:1558	SEM results indicated that homogeneous structures of cellulose and chitosan are deformed when blended with sodium alginate, and FTIR confirmed the proper formation of the desired blends.
31985373	3	62	theme	sodium	535:540	arg1	alginate					542:549	sodium alginate	535:549	sodium alginate	535:549	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	8	63	used	used	1163:1166	arg2	spectroscopy					1146:1157	Atomic absorption spectroscopy	1128:1157	Atomic absorption spectroscopy	1128:1157	Atomic absorption spectroscopy was used to study the levels of Pb.
31985373	14	64	dep	CONCLUSION	1918:1927	arg1	Modeling					1929:1936	Modeling	1929:1936	CONCLUSION Modeling	1918:1936	CONCLUSION Modeling, experimental and kinetic data highlight sodium alginate/water hyacinth root as a green route to remediate Pb+2 from wastewater.
31985373	3	65	theme	water	561:565	arg1	composites					521:530	composites	521:530	composites of sodium alginate and dried water hyacinth	521:574	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	65	theme	water	561:565	arg1	alginate					542:549	sodium alginate	535:549	sodium alginate	535:549	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	65	theme	water	561:565	arg1	water					561:565	dried water hyacinth	555:574	dried water hyacinth	555:574	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	4	66	theme	METHODS	591:597	arg1	modeling					609:616	MATERIALS AND METHODS Molecular modeling	577:616	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p)	577:636	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p) was utilized to study sodium alginate, cellulose and chitosan.
31985373	12	67	theme	further	1660:1666	arg1	deformation					1668:1678	further deformation	1660:1678	further deformation	1660:1678	SEM indicated further deformation in the morphology with the roughness of sodium alginate/water hyacinth microspheres, while FTIR confirmed the uniform matrices of the microspheres.
31985373	5	68	theme	Sodium	701:706	arg1	alginate					708:715	Sodium alginate	701:715	Sodium alginate	701:715	Sodium alginate was cross-linked with calcium chloride to form microspheres, then both sodium alginate/cellulose and sodium alginate/chitosan were also crosslinked as 50/50 to form microspheres.
31985373	14	69	theme	alginate/water	1986:1999	arg1	root					2010:2013	sodium alginate/water hyacinth root	1979:2013	sodium alginate/water hyacinth root	1979:2013	CONCLUSION Modeling, experimental and kinetic data highlight sodium alginate/water hyacinth root as a green route to remediate Pb+2 from wastewater.
31985373	14	69	theme	alginate/water	1986:1999	arg1	route					2026:2030	a green route	2018:2030	a green route to remediate Pb+2 from wastewater	2018:2064	CONCLUSION Modeling, experimental and kinetic data highlight sodium alginate/water hyacinth root as a green route to remediate Pb+2 from wastewater.
31985373	10	70	theme	SEM	1374:1376	arg1	results					1378:1384	SEM results	1374:1384	SEM results	1374:1384	SEM results indicated that homogeneous structures of cellulose and chitosan are deformed when blended with sodium alginate, and FTIR confirmed the proper formation of the desired blends.
31985373	14	71	theme	sodium	1979:1984	arg1	root					2010:2013	sodium alginate/water hyacinth root	1979:2013	sodium alginate/water hyacinth root	1979:2013	CONCLUSION Modeling, experimental and kinetic data highlight sodium alginate/water hyacinth root as a green route to remediate Pb+2 from wastewater.
31985373	14	71	theme	sodium	1979:1984	arg1	route					2026:2030	a green route	2018:2030	a green route to remediate Pb+2 from wastewater	2018:2064	CONCLUSION Modeling, experimental and kinetic data highlight sodium alginate/water hyacinth root as a green route to remediate Pb+2 from wastewater.
31985373	2	72	from	wastewater	293:302	arg1	pollutants					256:265	pollutants	256:265	pollutants of different sources from wastewater	256:302	Therefore, it is crucial to innovate different methods to remove pollutants of different sources from wastewater.
31985373	2	72	from	wastewater	293:302	arg1	sources					280:286	different sources	270:286	different sources from wastewater	270:302	Therefore, it is crucial to innovate different methods to remove pollutants of different sources from wastewater.
31985373	7	73	theme	structures	1103:1112	arg1	surface					1056:1062	the surface	1052:1062	the surface of the prepared microspheres and their structures	1052:1112	SEM and FTIR were employed to study the surface of the prepared microspheres and their structures respectively.
31985373	10	74	theme	homogeneous	1401:1411	arg1	structures					1413:1422	homogeneous structures	1401:1422	homogeneous structures of cellulose and chitosan	1401:1448	SEM results indicated that homogeneous structures of cellulose and chitosan are deformed when blended with sodium alginate, and FTIR confirmed the proper formation of the desired blends.
31985373	9	75	theme	such	1253:1256	arg1	structures					1258:1267	such structures	1253:1267	such structures	1253:1267	RESULTS Molecular modeling indicated that the blending of such structures enhances their ability to bind with surrounding molecules owing to their ability to form hydrogen bonds.
31985373	3	76	theme	lead	362:365	arg1	removal					351:357	the removal	347:357	the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth	347:574	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	7	77	theme	prepared	1071:1078	arg1	microspheres					1080:1091	the prepared microspheres	1067:1091	the prepared microspheres	1067:1091	SEM and FTIR were employed to study the surface of the prepared microspheres and their structures respectively.
31985373	1	78	theme	Wastewater	78:87	arg1	AIM					60:62	AIM	60:62	AIM	60:62	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	1	78	theme	Wastewater	78:87	arg1	process					131:137	a very important process	114:137	a very important process that has a great environmental and economic impact	114:188	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	1	78	theme	Wastewater	78:87	arg1	treatment/remediation					89:109	OBJECTIVE Wastewater treatment/remediation	68:109	OBJECTIVE Wastewater treatment/remediation	68:109	AIM AND OBJECTIVE Wastewater treatment/remediation is a very important process that has a great environmental and economic impact.
31985373	6	79	dep	70	1011:1012	arg1	to					1008:1009	to	1008:1009	to	1008:1009	The roots of the aquatic plant water hyacinth in dry form were added to the cross-linked sodium alginate for up to 70%.
31985373	3	80	theme	alginate	433:440	arg1	chitosan					457:464	chitosan	457:464	chitosan	457:464	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	80	theme	alginate	433:440	arg1	cellulose					443:451	cellulose	443:451	cellulose	443:451	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	80	theme	alginate	433:440	arg1	composites					412:421	composites	412:421	composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth	412:574	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	80	theme	alginate	433:440	arg1	alginate					433:440	sodium alginate	426:440	sodium alginate	426:440	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	6	81	theme	sodium	985:990	arg1	alginate					992:999	the cross-linked sodium alginate	968:999	the cross-linked sodium alginate for up to 70%	968:1013	The roots of the aquatic plant water hyacinth in dry form were added to the cross-linked sodium alginate for up to 70%.
31985373	3	82	theme	chitosan	457:464	arg1	chitosan					457:464	chitosan	457:464	chitosan	457:464	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	82	theme	chitosan	457:464	arg1	cellulose					443:451	cellulose	443:451	cellulose	443:451	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	82	theme	chitosan	457:464	arg1	composites					412:421	composites	412:421	composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth	412:574	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	82	theme	chitosan	457:464	arg1	alginate					433:440	sodium alginate	426:440	sodium alginate	426:440	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	11	83	attach	remove	1617:1622	arg1	wastewater					1634:1643	wastewater	1634:1643	wastewater	1634:1643	Microspheres from sodium alginate showed the ability to remove Pb+2 from wastewater.
31985373	11	83	attach	remove	1617:1622	arg2	ability					1606:1612	the ability to remove Pb+2 from wastewater	1602:1643	the ability to remove Pb+2 from wastewater	1602:1643	Microspheres from sodium alginate showed the ability to remove Pb+2 from wastewater.
31985373	9	84	theme	surrounding	1305:1315	arg1	molecules					1317:1325	surrounding molecules	1305:1325	surrounding molecules owing to their ability to form hydrogen bonds	1305:1371	RESULTS Molecular modeling indicated that the blending of such structures enhances their ability to bind with surrounding molecules owing to their ability to form hydrogen bonds.
31985373	6	85	from	roots	900:904	arg1	form					949:952	dry form	945:952	dry form	945:952	The roots of the aquatic plant water hyacinth in dry form were added to the cross-linked sodium alginate for up to 70%.
31985373	3	86	from	wastewater	379:388	arg1	removal					351:357	the removal	347:357	the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth	347:574	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	87	theme	cellulose	443:451	arg1	chitosan					457:464	chitosan	457:464	chitosan	457:464	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	87	theme	cellulose	443:451	arg1	cellulose					443:451	cellulose	443:451	cellulose	443:451	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	87	theme	cellulose	443:451	arg1	composites					412:421	composites	412:421	composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth	412:574	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	3	87	theme	cellulose	443:451	arg1	alginate					433:440	sodium alginate	426:440	sodium alginate	426:440	This work was conducted in order to study the removal of lead (Pb+2) from wastewater using microspheres of composites of sodium alginate, cellulose and chitosan, as well as using a cost-effective green route through composites of sodium alginate and dried water hyacinth.
31985373	4	88	dep	B3LYP/6-31g	621:631	arg1	p					635:635	p	635:635	p	635:635	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p) was utilized to study sodium alginate, cellulose and chitosan.
31985373	4	88	dep	B3LYP/6-31g	621:631	arg1	d					633:633	d	633:633	d	633:633	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p) was utilized to study sodium alginate, cellulose and chitosan.
31985373	12	89	theme	alginate/water	1727:1740	arg1	microspheres					1751:1762	sodium alginate/water hyacinth microspheres	1720:1762	sodium alginate/water hyacinth microspheres	1720:1762	SEM indicated further deformation in the morphology with the roughness of sodium alginate/water hyacinth microspheres, while FTIR confirmed the uniform matrices of the microspheres.
31985373	4	90	theme	MATERIALS	577:585	arg1	modeling					609:616	MATERIALS AND METHODS Molecular modeling	577:616	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p)	577:636	MATERIALS AND METHODS Molecular modeling at B3LYP/6-31g(d,p) was utilized to study sodium alginate, cellulose and chitosan.
32126200	0	0	theme	azo	106:108	arg1	dyes					110:113	azo dyes	106:113	azo dyes	106:113	Chitosan‑zinc sulfide nanoparticles, characterization and their photocatalytic degradation efficiency for azo dyes.
32126200	6	1	theme	Black	738:742	arg1	dyes					709:712	two carcinogenic azo dyes	688:712	two carcinogenic azo dyes	688:712	The photocatalytic efficiency of CS-ZnS-NPs was evaluated using two carcinogenic azo dyes, Acid Brown 98 and Acid Black 234.
32126200	6	1	theme	Black	738:742	arg1	Acid					733:736	Acid Black 234	733:746	Acid Black 234	733:746	The photocatalytic efficiency of CS-ZnS-NPs was evaluated using two carcinogenic azo dyes, Acid Brown 98 and Acid Black 234.
32126200	8	2	from	Brown	977:981	arg1	165 min					989:995	165 min	989:995	165 min	989:995	At the optimum conditions, the synthesized CS-ZnS-NPs showed 96.7% degradation for Acid Black 234 in 100 min and 92.6% for Acid Brown 98 in 165 min.
32126200	6	3	theme	CS-ZnS-NPs	657:666	arg1	efficiency					643:652	The photocatalytic efficiency	624:652	The photocatalytic efficiency of CS-ZnS-NPs	624:666	The photocatalytic efficiency of CS-ZnS-NPs was evaluated using two carcinogenic azo dyes, Acid Brown 98 and Acid Black 234.
32126200	12	4	from	photocatalyst	1414:1426	arg1	cycles					1475:1480	several consecutive cycles	1455:1480	several consecutive cycles	1455:1480	The results showed that CS-ZnS-NPs are considered as highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles.
32126200	12	4	from	photocatalyst	1414:1426	arg1	pollutants					1441:1450	degrading pollutants	1431:1450	degrading pollutants	1431:1450	The results showed that CS-ZnS-NPs are considered as highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles.
32126200	4	5	theme	nanocomposite	515:527	arg1	analysis					499:506	the compositional analysis	481:506	the compositional analysis of the nanocomposite	481:527	The SEM envisaged the average particle size as 40 nm, whereas EDS interpreted the compositional analysis of the nanocomposite.
32126200	5	6	theme	CS-ZnS-NPs	612:621	arg1	crystallinity					559:571	crystallinity	559:571	crystallinity	559:571	XRD analysis illustrated the crystallinity and hexagonal crystal structure of the CS-ZnS-NPs.
32126200	5	6	theme	CS-ZnS-NPs	612:621	arg1	structure					595:603	hexagonal crystal structure	577:603	hexagonal crystal structure	577:603	XRD analysis illustrated the crystallinity and hexagonal crystal structure of the CS-ZnS-NPs.
32126200	9	7	theme	pseudo-first-order	1033:1050	arg1	kinetics					1052:1059	pseudo-first-order kinetics	1033:1059	pseudo-first-order kinetics	1033:1059	The degradation phenomena followed pseudo-first-order kinetics.
32126200	3	8	theme	CS-ZnS-NPs	353:362	arg1	CS-ZnS-NPs					353:362	CS-ZnS-NPs	353:362	CS-ZnS-NPs	353:362	The functional groups of CS-ZnS-NPs were validated with FTIR spectroscopy.
32126200	3	8	theme	CS-ZnS-NPs	353:362	arg1	groups					343:348	The functional groups	328:348	The functional groups of CS-ZnS-NPs	328:362	The functional groups of CS-ZnS-NPs were validated with FTIR spectroscopy.
32126200	12	9	theme	degrading	1431:1439	arg1	pollutants					1441:1450	degrading pollutants	1431:1450	degrading pollutants	1431:1450	The results showed that CS-ZnS-NPs are considered as highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles.
32126200	12	10	theme	cost-effective	1385:1398	arg1	CS-ZnS-NPs					1337:1346	CS-ZnS-NPs	1337:1346	CS-ZnS-NPs	1337:1346	The results showed that CS-ZnS-NPs are considered as highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles.
32126200	12	10	theme	cost-effective	1385:1398	arg1	photocatalyst					1414:1426	highly productive, cost-effective and promising photocatalyst	1366:1426	highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles	1366:1480	The results showed that CS-ZnS-NPs are considered as highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles.
32126200	6	11	theme	Brown	720:724	arg1	Acid					715:718	Acid Brown 98	715:727	Acid Brown 98	715:727	The photocatalytic efficiency of CS-ZnS-NPs was evaluated using two carcinogenic azo dyes, Acid Brown 98 and Acid Black 234.
32126200	6	11	theme	Brown	720:724	arg1	dyes					709:712	two carcinogenic azo dyes	688:712	two carcinogenic azo dyes	688:712	The photocatalytic efficiency of CS-ZnS-NPs was evaluated using two carcinogenic azo dyes, Acid Brown 98 and Acid Black 234.
32126200	12	12	theme	productive	1373:1382	arg1	CS-ZnS-NPs					1337:1346	CS-ZnS-NPs	1337:1346	CS-ZnS-NPs	1337:1346	The results showed that CS-ZnS-NPs are considered as highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles.
32126200	12	12	theme	productive	1373:1382	arg1	photocatalyst					1414:1426	highly productive, cost-effective and promising photocatalyst	1366:1426	highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles	1366:1480	The results showed that CS-ZnS-NPs are considered as highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles.
32126200	8	13	theme	optimum	856:862	arg1	conditions					864:873	the optimum conditions	852:873	the optimum conditions	852:873	At the optimum conditions, the synthesized CS-ZnS-NPs showed 96.7% degradation for Acid Black 234 in 100 min and 92.6% for Acid Brown 98 in 165 min.
32126200	8	14	from	Acid	932:935	arg1	100 min					950:956	100 min	950:956	100 min	950:956	At the optimum conditions, the synthesized CS-ZnS-NPs showed 96.7% degradation for Acid Black 234 in 100 min and 92.6% for Acid Brown 98 in 165 min.
32126200	10	15	theme	0.98891	1162:1168	arg1	R2					1155:1156	R2	1155:1156	R2	1155:1156	The values of rate constant (k) were 0.01464 and 0.04096 min-1 with correlation coefficient (R2) of 0.98891 and 0.99406 for Acid Brown 98 and Acid Black 234, respectively.
32126200	10	15	theme	0.98891	1162:1168	arg1	coefficient					1142:1152	correlation coefficient	1130:1152	correlation coefficient (R2) of 0.98891	1130:1168	The values of rate constant (k) were 0.01464 and 0.04096 min-1 with correlation coefficient (R2) of 0.98891 and 0.99406 for Acid Brown 98 and Acid Black 234, respectively.
32126200	4	16	theme	compositional	485:497	arg1	analysis					499:506	the compositional analysis	481:506	the compositional analysis of the nanocomposite	481:527	The SEM envisaged the average particle size as 40 nm, whereas EDS interpreted the compositional analysis of the nanocomposite.
32126200	5	17	theme	crystal	587:593	arg1	structure					595:603	hexagonal crystal structure	577:603	hexagonal crystal structure	577:603	XRD analysis illustrated the crystallinity and hexagonal crystal structure of the CS-ZnS-NPs.
32126200	11	18	theme	successive	1293:1302	arg1	batches					1304:1310	four successive batches	1288:1310	four successive batches	1288:1310	The CS-ZnS-NPs were easily recovered and recycled for four successive batches.
32126200	7	19	theme	dyes	843:846	arg1	degradation					828:838	the photocatalytic degradation	809:838	the photocatalytic degradation of dyes	809:846	A UV lamp (254 nm) was used as an irradiation source during the photocatalytic degradation of dyes.
32126200	3	20	theme	FTIR	384:387	arg1	spectroscopy					389:400	FTIR spectroscopy	384:400	FTIR spectroscopy	384:400	The functional groups of CS-ZnS-NPs were validated with FTIR spectroscopy.
32126200	10	21	theme	rate	1076:1079	arg1	constant					1081:1088	rate constant	1076:1088	rate constant (k)	1076:1092	The values of rate constant (k) were 0.01464 and 0.04096 min-1 with correlation coefficient (R2) of 0.98891 and 0.99406 for Acid Brown 98 and Acid Black 234, respectively.
32126200	10	21	theme	rate	1076:1079	arg1	k					1091:1091	k	1091:1091	k	1091:1091	The values of rate constant (k) were 0.01464 and 0.04096 min-1 with correlation coefficient (R2) of 0.98891 and 0.99406 for Acid Brown 98 and Acid Black 234, respectively.
32126200	8	22	theme	Acid	972:975	arg1	Brown					977:981	Acid Brown 98	972:984	Acid Brown 98 in 165 min	972:995	At the optimum conditions, the synthesized CS-ZnS-NPs showed 96.7% degradation for Acid Black 234 in 100 min and 92.6% for Acid Brown 98 in 165 min.
32126200	5	23	dep	crystallinity	559:571	arg1	the					555:557	the	555:557	the	555:557	XRD analysis illustrated the crystallinity and hexagonal crystal structure of the CS-ZnS-NPs.
32126200	1	24	theme	efficient	194:202	arg1	nanoparticles					146:158	chitosan‑zinc sulfide nanoparticles	124:158	chitosan‑zinc sulfide nanoparticles (CS-ZnS-NPs)	124:171	Herein, chitosan‑zinc sulfide nanoparticles (CS-ZnS-NPs) were developed as an efficient photocatalyst for the degradation of toxic dyes.
32126200	1	24	theme	efficient	194:202	arg1	photocatalyst					204:216	an efficient photocatalyst	191:216	an efficient photocatalyst for the degradation of toxic dyes	191:250	Herein, chitosan‑zinc sulfide nanoparticles (CS-ZnS-NPs) were developed as an efficient photocatalyst for the degradation of toxic dyes.
32126200	0	25	theme	Chitosan‑zinc	0:12	arg1	sulfide					14:20	Chitosan‑zinc sulfide	0:20	Chitosan‑zinc sulfide	0:20	Chitosan‑zinc sulfide nanoparticles, characterization and their photocatalytic degradation efficiency for azo dyes.
32126200	7	26	used	used	772:775	arg2	254 nm					760:765	254 nm	760:765	254 nm	760:765	A UV lamp (254 nm) was used as an irradiation source during the photocatalytic degradation of dyes.
32126200	7	26	used	used	772:775	arg2	lamp					754:757	A UV lamp	749:757	A UV lamp (254 nm)	749:766	A UV lamp (254 nm) was used as an irradiation source during the photocatalytic degradation of dyes.
32126200	7	26	used	used	772:775	arg2	source					795:800	an irradiation source	780:800	an irradiation source	780:800	A UV lamp (254 nm) was used as an irradiation source during the photocatalytic degradation of dyes.
32126200	12	27	theme	several	1455:1461	arg1	cycles					1475:1480	several consecutive cycles	1455:1480	several consecutive cycles	1455:1480	The results showed that CS-ZnS-NPs are considered as highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles.
32126200	12	28	theme	promising	1404:1412	arg1	CS-ZnS-NPs					1337:1346	CS-ZnS-NPs	1337:1346	CS-ZnS-NPs	1337:1346	The results showed that CS-ZnS-NPs are considered as highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles.
32126200	12	28	theme	promising	1404:1412	arg1	photocatalyst					1414:1426	highly productive, cost-effective and promising photocatalyst	1366:1426	highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles	1366:1480	The results showed that CS-ZnS-NPs are considered as highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles.
32126200	8	29	theme	synthesized	880:890	arg1	CS-ZnS-NPs					892:901	the synthesized CS-ZnS-NPs	876:901	the synthesized CS-ZnS-NPs	876:901	At the optimum conditions, the synthesized CS-ZnS-NPs showed 96.7% degradation for Acid Black 234 in 100 min and 92.6% for Acid Brown 98 in 165 min.
32126200	8	30	theme	Black	937:941	arg1	Acid					932:935	Acid Black 234	932:945	Acid Black 234 in 100 min	932:956	At the optimum conditions, the synthesized CS-ZnS-NPs showed 96.7% degradation for Acid Black 234 in 100 min and 92.6% for Acid Brown 98 in 165 min.
32126200	7	31	theme	photocatalytic	813:826	arg1	degradation					828:838	the photocatalytic degradation	809:838	the photocatalytic degradation of dyes	809:846	A UV lamp (254 nm) was used as an irradiation source during the photocatalytic degradation of dyes.
32126200	8	32	theme	96.7	910:913	arg1	%					914:914	%	914:914	%	914:914	At the optimum conditions, the synthesized CS-ZnS-NPs showed 96.7% degradation for Acid Black 234 in 100 min and 92.6% for Acid Brown 98 in 165 min.
32126200	10	33	theme	constant	1081:1088	arg1	values					1066:1071	The values	1062:1071	The values of rate constant (k)	1062:1092	The values of rate constant (k) were 0.01464 and 0.04096 min-1 with correlation coefficient (R2) of 0.98891 and 0.99406 for Acid Brown 98 and Acid Black 234, respectively.
32126200	10	33	theme	constant	1081:1088	arg1	0.01464					1099:1105	0.01464	1099:1105	0.01464	1099:1105	The values of rate constant (k) were 0.01464 and 0.04096 min-1 with correlation coefficient (R2) of 0.98891 and 0.99406 for Acid Brown 98 and Acid Black 234, respectively.
32126200	7	34	theme	irradiation	783:793	arg1	lamp					754:757	A UV lamp	749:757	A UV lamp (254 nm)	749:766	A UV lamp (254 nm) was used as an irradiation source during the photocatalytic degradation of dyes.
32126200	7	34	theme	irradiation	783:793	arg1	source					795:800	an irradiation source	780:800	an irradiation source	780:800	A UV lamp (254 nm) was used as an irradiation source during the photocatalytic degradation of dyes.
32126200	10	35	theme	Black	1209:1213	arg1	Acid					1204:1207	Acid Black 234	1204:1217	Acid Black 234	1204:1217	The values of rate constant (k) were 0.01464 and 0.04096 min-1 with correlation coefficient (R2) of 0.98891 and 0.99406 for Acid Brown 98 and Acid Black 234, respectively.
32126200	6	36	theme	azo	705:707	arg1	Acid					715:718	Acid Brown 98	715:727	Acid Brown 98	715:727	The photocatalytic efficiency of CS-ZnS-NPs was evaluated using two carcinogenic azo dyes, Acid Brown 98 and Acid Black 234.
32126200	6	36	theme	azo	705:707	arg1	dyes					709:712	two carcinogenic azo dyes	688:712	two carcinogenic azo dyes	688:712	The photocatalytic efficiency of CS-ZnS-NPs was evaluated using two carcinogenic azo dyes, Acid Brown 98 and Acid Black 234.
32126200	6	36	theme	azo	705:707	arg1	Acid					733:736	Acid Black 234	733:746	Acid Black 234	733:746	The photocatalytic efficiency of CS-ZnS-NPs was evaluated using two carcinogenic azo dyes, Acid Brown 98 and Acid Black 234.
32126200	0	37	theme	photocatalytic	64:77	arg1	efficiency					91:100	their photocatalytic degradation efficiency	58:100	their photocatalytic degradation efficiency for azo dyes	58:113	Chitosan‑zinc sulfide nanoparticles, characterization and their photocatalytic degradation efficiency for azo dyes.
32126200	10	38	theme	correlation	1130:1140	arg1	R2					1155:1156	R2	1155:1156	R2	1155:1156	The values of rate constant (k) were 0.01464 and 0.04096 min-1 with correlation coefficient (R2) of 0.98891 and 0.99406 for Acid Brown 98 and Acid Black 234, respectively.
32126200	10	38	theme	correlation	1130:1140	arg1	coefficient					1142:1152	correlation coefficient	1130:1152	correlation coefficient (R2) of 0.98891	1130:1168	The values of rate constant (k) were 0.01464 and 0.04096 min-1 with correlation coefficient (R2) of 0.98891 and 0.99406 for Acid Brown 98 and Acid Black 234, respectively.
32126200	0	39	theme	degradation	79:89	arg1	efficiency					91:100	their photocatalytic degradation efficiency	58:100	their photocatalytic degradation efficiency for azo dyes	58:113	Chitosan‑zinc sulfide nanoparticles, characterization and their photocatalytic degradation efficiency for azo dyes.
32126200	8	40	theme	%	914:914	arg1	degradation					916:926	96.7% degradation	910:926	96.7% degradation for Acid Black 234 in 100 min	910:956	At the optimum conditions, the synthesized CS-ZnS-NPs showed 96.7% degradation for Acid Black 234 in 100 min and 92.6% for Acid Brown 98 in 165 min.
32126200	1	41	theme	chitosan‑zinc	124:136	arg1	nanoparticles					146:158	chitosan‑zinc sulfide nanoparticles	124:158	chitosan‑zinc sulfide nanoparticles (CS-ZnS-NPs)	124:171	Herein, chitosan‑zinc sulfide nanoparticles (CS-ZnS-NPs) were developed as an efficient photocatalyst for the degradation of toxic dyes.
32126200	1	41	theme	chitosan‑zinc	124:136	arg1	photocatalyst					204:216	an efficient photocatalyst	191:216	an efficient photocatalyst for the degradation of toxic dyes	191:250	Herein, chitosan‑zinc sulfide nanoparticles (CS-ZnS-NPs) were developed as an efficient photocatalyst for the degradation of toxic dyes.
32126200	1	41	theme	chitosan‑zinc	124:136	arg1	CS-ZnS-NPs					161:170	CS-ZnS-NPs	161:170	CS-ZnS-NPs	161:170	Herein, chitosan‑zinc sulfide nanoparticles (CS-ZnS-NPs) were developed as an efficient photocatalyst for the degradation of toxic dyes.
32126200	4	42	theme	average	425:431	arg1	size					442:445	the average particle size	421:445	the average particle size as 40 nm	421:454	The SEM envisaged the average particle size as 40 nm, whereas EDS interpreted the compositional analysis of the nanocomposite.
32126200	1	43	theme	sulfide	138:144	arg1	nanoparticles					146:158	chitosan‑zinc sulfide nanoparticles	124:158	chitosan‑zinc sulfide nanoparticles (CS-ZnS-NPs)	124:171	Herein, chitosan‑zinc sulfide nanoparticles (CS-ZnS-NPs) were developed as an efficient photocatalyst for the degradation of toxic dyes.
32126200	1	43	theme	sulfide	138:144	arg1	photocatalyst					204:216	an efficient photocatalyst	191:216	an efficient photocatalyst for the degradation of toxic dyes	191:250	Herein, chitosan‑zinc sulfide nanoparticles (CS-ZnS-NPs) were developed as an efficient photocatalyst for the degradation of toxic dyes.
32126200	1	43	theme	sulfide	138:144	arg1	CS-ZnS-NPs					161:170	CS-ZnS-NPs	161:170	CS-ZnS-NPs	161:170	Herein, chitosan‑zinc sulfide nanoparticles (CS-ZnS-NPs) were developed as an efficient photocatalyst for the degradation of toxic dyes.
32126200	6	44	theme	carcinogenic	692:703	arg1	Acid					715:718	Acid Brown 98	715:727	Acid Brown 98	715:727	The photocatalytic efficiency of CS-ZnS-NPs was evaluated using two carcinogenic azo dyes, Acid Brown 98 and Acid Black 234.
32126200	6	44	theme	carcinogenic	692:703	arg1	dyes					709:712	two carcinogenic azo dyes	688:712	two carcinogenic azo dyes	688:712	The photocatalytic efficiency of CS-ZnS-NPs was evaluated using two carcinogenic azo dyes, Acid Brown 98 and Acid Black 234.
32126200	6	44	theme	carcinogenic	692:703	arg1	Acid					733:736	Acid Black 234	733:746	Acid Black 234	733:746	The photocatalytic efficiency of CS-ZnS-NPs was evaluated using two carcinogenic azo dyes, Acid Brown 98 and Acid Black 234.
32126200	5	45	theme	hexagonal	577:585	arg1	structure					595:603	hexagonal crystal structure	577:603	hexagonal crystal structure	577:603	XRD analysis illustrated the crystallinity and hexagonal crystal structure of the CS-ZnS-NPs.
32126200	1	46	theme	toxic	241:245	arg1	dyes					247:250	toxic dyes	241:250	toxic dyes	241:250	Herein, chitosan‑zinc sulfide nanoparticles (CS-ZnS-NPs) were developed as an efficient photocatalyst for the degradation of toxic dyes.
32126200	10	47	theme	Brown	1191:1195	arg1	Acid					1186:1189	Acid Brown 98	1186:1198	Acid Brown 98	1186:1198	The values of rate constant (k) were 0.01464 and 0.04096 min-1 with correlation coefficient (R2) of 0.98891 and 0.99406 for Acid Brown 98 and Acid Black 234, respectively.
32126200	1	48	theme	dyes	247:250	arg1	degradation					226:236	the degradation	222:236	the degradation of toxic dyes	222:250	Herein, chitosan‑zinc sulfide nanoparticles (CS-ZnS-NPs) were developed as an efficient photocatalyst for the degradation of toxic dyes.
32126200	4	49	theme	particle	433:440	arg1	size					442:445	the average particle size	421:445	the average particle size as 40 nm	421:454	The SEM envisaged the average particle size as 40 nm, whereas EDS interpreted the compositional analysis of the nanocomposite.
32126200	5	50	theme	XRD	530:532	arg1	analysis					534:541	XRD analysis	530:541	XRD analysis	530:541	XRD analysis illustrated the crystallinity and hexagonal crystal structure of the CS-ZnS-NPs.
32126200	9	51	theme	degradation	1002:1012	arg1	phenomena					1014:1022	The degradation phenomena	998:1022	The degradation phenomena	998:1022	The degradation phenomena followed pseudo-first-order kinetics.
32126200	7	52	theme	UV	751:752	arg1	lamp					754:757	A UV lamp	749:757	A UV lamp (254 nm)	749:766	A UV lamp (254 nm) was used as an irradiation source during the photocatalytic degradation of dyes.
32126200	7	52	theme	UV	751:752	arg1	source					795:800	an irradiation source	780:800	an irradiation source	780:800	A UV lamp (254 nm) was used as an irradiation source during the photocatalytic degradation of dyes.
32126200	7	52	theme	UV	751:752	arg1	254 nm					760:765	254 nm	760:765	254 nm	760:765	A UV lamp (254 nm) was used as an irradiation source during the photocatalytic degradation of dyes.
32126200	3	53	theme	functional	332:341	arg1	CS-ZnS-NPs					353:362	CS-ZnS-NPs	353:362	CS-ZnS-NPs	353:362	The functional groups of CS-ZnS-NPs were validated with FTIR spectroscopy.
32126200	3	53	theme	functional	332:341	arg1	groups					343:348	The functional groups	328:348	The functional groups of CS-ZnS-NPs	328:362	The functional groups of CS-ZnS-NPs were validated with FTIR spectroscopy.
32126200	2	54	theme	as-synthesized	257:270	arg1	CS-ZnS-NPs					272:281	The as-synthesized CS-ZnS-NPs	253:281	The as-synthesized CS-ZnS-NPs	253:281	The as-synthesized CS-ZnS-NPs were analyzed using XRD, FTIR, SEM, and EDS.
32126200	6	55	theme	photocatalytic	628:641	arg1	efficiency					643:652	The photocatalytic efficiency	624:652	The photocatalytic efficiency of CS-ZnS-NPs	624:666	The photocatalytic efficiency of CS-ZnS-NPs was evaluated using two carcinogenic azo dyes, Acid Brown 98 and Acid Black 234.
32126200	4	56	dep	envisaged	411:419	arg1	whereas					457:463	whereas	457:463	whereas	457:463	The SEM envisaged the average particle size as 40 nm, whereas EDS interpreted the compositional analysis of the nanocomposite.
32126200	12	57	theme	consecutive	1463:1473	arg1	cycles					1475:1480	several consecutive cycles	1455:1480	several consecutive cycles	1455:1480	The results showed that CS-ZnS-NPs are considered as highly productive, cost-effective and promising photocatalyst in degrading pollutants in several consecutive cycles.
34933002	0	0	theme	Pilot	162:166	arg1	studies					168:174	Pilot studies	162:174	Pilot studies	162:174	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	1	1	theme	black	374:378	arg1	B					392:392	B	392:392	B	392:392	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	1	1	theme	black	374:378	arg1	population					380:389	the black population	370:389	the black population (B)	370:393	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	4	2	theme	Bradford	830:837	arg1	assay					847:851	Bradford protein assay	830:851	Bradford protein assay	830:851	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	3	3	theme	healthy	663:669	arg1	subjects					671:678	healthy subjects	663:678	healthy subjects	663:678	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	6	4	theme	-oxalate	1207:1214	arg1	deposition					1216:1225	[14C]-oxalate deposition	1202:1225	[14C]-oxalate deposition	1202:1225	Nucleation, growth and aggregation were measured by Coulter particle counting, spectrophotometric assay and [14C]-oxalate deposition.
34933002	0	5	with	groups	105:110	arg1	rates					138:142	different occurrence rates	117:142	different occurrence rates of kidney stones	117:159	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	4	6	theme	liquid	871:876	arg1	chromatography					878:891	high performance liquid chromatography	854:891	high performance liquid chromatography	854:891	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	9	7	theme	occurrence	1621:1630	arg1	rate					1632:1635	the lower stone occurrence rate	1605:1635	the lower stone occurrence rate in B	1605:1640	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	6	8	theme	spectrophotometric	1173:1190	arg1	assay					1192:1196	spectrophotometric assay	1173:1196	spectrophotometric assay	1173:1196	Nucleation, growth and aggregation were measured by Coulter particle counting, spectrophotometric assay and [14C]-oxalate deposition.
34933002	0	9	theme	occurrence	127:136	arg1	rates					138:142	different occurrence rates	117:142	different occurrence rates of kidney stones	117:159	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	9	10	theme	inhibitory	1415:1424	arg1	effect					1426:1431	the stronger inhibitory effect	1402:1431	the stronger inhibitory effect of PGB to its higher content of CS	1402:1466	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	9	11	theme	contributory	1567:1578	arg1	factor					1580:1585	a contributory factor	1565:1585	a contributory factor	1565:1585	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	9	11	theme	contributory	1567:1578	arg1	inhibition					1498:1507	the superior inhibition	1485:1507	the superior inhibition of CaOx crystallization by PGB relative to PGW	1485:1554	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	4	12	theme	high	854:857	arg1	chromatography					878:891	high performance liquid chromatography	854:891	high performance liquid chromatography	854:891	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	6	13	dep	Coulter	1146:1152	arg1	counting					1163:1170	particle counting	1154:1170	particle counting	1154:1170	Nucleation, growth and aggregation were measured by Coulter particle counting, spectrophotometric assay and [14C]-oxalate deposition.
34933002	0	14	theme	stones	154:159	arg1	rates					138:142	different occurrence rates	117:142	different occurrence rates of kidney stones	117:159	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	5	15	theme	purified	1029:1036	arg1	PG					1044:1045	PG	1044:1045	PG	1044:1045	CaOx crystal inhibition was determined in ultrafiltered urinary fractions to which purified GAGS (PG) from each group (PGB and PGW) had been added.
34933002	5	15	theme	purified	1029:1036	arg1	GAGS					1038:1041	purified GAGS	1029:1041	purified GAGS (PG) from each group (PGB and PGW)	1029:1076	CaOx crystal inhibition was determined in ultrafiltered urinary fractions to which purified GAGS (PG) from each group (PGB and PGW) had been added.
34933002	2	16	theme	urinary	428:434	arg1	GAGs					456:459	GAGs	456:459	GAGs	456:459	The possible role of endogenous urinary glycosaminoglycans (GAGs) has not been previously investigated in this context.
34933002	2	16	theme	urinary	428:434	arg1	glycosaminoglycans					436:453	endogenous urinary glycosaminoglycans	417:453	endogenous urinary glycosaminoglycans (GAGs)	417:460	The possible role of endogenous urinary glycosaminoglycans (GAGs) has not been previously investigated in this context.
34933002	1	17	theme	stone	303:307	arg1	disease					309:315	BACKGROUND Calcium oxalate (CaOx) kidney stone disease	262:315	BACKGROUND Calcium oxalate (CaOx) kidney stone disease	262:315	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	5	18	from	group	1058:1062	arg1	PG					1044:1045	PG	1044:1045	PG	1044:1045	CaOx crystal inhibition was determined in ultrafiltered urinary fractions to which purified GAGS (PG) from each group (PGB and PGW) had been added.
34933002	5	18	from	group	1058:1062	arg1	GAGS					1038:1041	purified GAGS	1029:1041	purified GAGS (PG) from each group (PGB and PGW)	1029:1076	CaOx crystal inhibition was determined in ultrafiltered urinary fractions to which purified GAGS (PG) from each group (PGB and PGW) had been added.
34933002	9	19	theme	higher	1447:1452	arg1	content					1454:1460	its higher content	1443:1460	its higher content of CS	1443:1466	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	1	20	from	rare	362:365	arg1	B					392:392	B	392:392	B	392:392	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	1	20	from	rare	362:365	arg1	population					380:389	the black population	370:389	the black population (B)	370:393	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	0	21	theme	inhibitory	217:226	arg1	role					228:231	an inhibitory role	214:231	an inhibitory role for this group of compounds	214:259	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	4	22	dep	MATERIALS	698:706	arg1	GAGS					720:723	GAGS	720:723	GAGS	720:723	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	9	23	from	rate	1632:1635	arg1	B					1640:1640	B	1640:1640	B	1640:1640	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	4	24	theme	anion	898:902	arg1	exchange					904:911	anion exchange	898:911	anion exchange	898:911	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	4	25	theme	high	913:916	arg1	chromatography					930:943	high performance chromatography	913:943	high performance chromatography	913:943	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	0	26	theme	race	100:103	arg1	groups					105:110	two race groups	96:110	two race groups with different occurrence rates of kidney stones	96:159	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	1	27	theme	African	336:342	arg1	W					352:352	W	352:352	W	352:352	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	1	27	theme	African	336:342	arg1	whites					344:349	South African whites	330:349	South African whites (W)	330:353	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	5	28	theme	CaOx	946:949	arg1	inhibition					959:968	CaOx crystal inhibition	946:968	CaOx crystal inhibition	946:968	CaOx crystal inhibition was determined in ultrafiltered urinary fractions to which purified GAGS (PG) from each group (PGB and PGW) had been added.
34933002	3	29	from	groups	690:695	arg1	CaOx					575:578	CaOx	575:578	CaOx	575:578	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	29	from	groups	690:695	arg1	structure					561:569	structure	561:569	structure	561:569	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	29	from	groups	690:695	arg1	composition					548:558	composition	548:558	composition	548:558	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	29	from	groups	690:695	arg1	urine					654:658	ultrafiltered urine	640:658	ultrafiltered urine of healthy subjects from both groups	640:695	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	29	from	groups	690:695	arg1	concentration					533:545	concentration	533:545	concentration	533:545	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	1	30	from	whites	344:349	arg1	common					320:325	common	320:325	common	320:325	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	0	31	theme	compounds	251:259	arg1	group					242:246	this group	237:246	this group of compounds	237:259	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	0	31	theme	compounds	251:259	arg1	compounds					251:259	compounds	251:259	compounds	251:259	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	9	32	theme	superior	1489:1496	arg1	factor					1580:1585	a contributory factor	1565:1585	a contributory factor	1565:1585	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	9	32	theme	superior	1489:1496	arg1	inhibition					1498:1507	the superior inhibition	1485:1507	the superior inhibition of CaOx crystallization by PGB relative to PGW	1485:1554	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	0	33	theme	inhibitory	16:25	arg1	properties					27:36	inhibitory properties	16:36	inhibitory properties	16:36	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	1	34	theme	Calcium	273:279	arg1	CaOx					290:293	CaOx	290:293	CaOx	290:293	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	1	34	theme	Calcium	273:279	arg1	oxalate					281:287	BACKGROUND Calcium oxalate	262:287	BACKGROUND Calcium oxalate (CaOx) kidney stone disease	262:315	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	7	35	theme	chondroitin	1261:1271	arg1	CS					1282:1283	CS	1282:1283	CS	1282:1283	RESULTS Higher concentrations of chondroitin sulfate (CS) were found in PGB than in PGW.
34933002	7	35	theme	chondroitin	1261:1271	arg1	sulfate					1273:1279	chondroitin sulfate	1261:1279	chondroitin sulfate (CS)	1261:1284	RESULTS Higher concentrations of chondroitin sulfate (CS) were found in PGB than in PGW.
34933002	2	36	theme	possible	400:407	arg1	role					409:412	The possible role	396:412	The possible role of endogenous urinary glycosaminoglycans (GAGs)	396:460	The possible role of endogenous urinary glycosaminoglycans (GAGs) has not been previously investigated in this context.
34933002	3	37	theme	crystal-inhibiting	580:597	arg1	properties					599:608	crystal-inhibiting properties	580:608	crystal-inhibiting properties	580:608	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	9	38	dep	CONCLUSIONS	1377:1387	arg1	suggest					1472:1478	suggest	1472:1478	suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B	1472:1640	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	9	38	dep	CONCLUSIONS	1377:1387	arg1	attribute					1392:1400	attribute	1392:1400	attribute the stronger inhibitory effect of PGB to its higher content of CS	1392:1466	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	1	39	from	common	320:325	arg1	W					352:352	W	352:352	W	352:352	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	1	39	from	common	320:325	arg1	whites					344:349	South African whites	330:349	South African whites (W)	330:353	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	9	40	theme	crystallization	1517:1531	arg1	factor					1580:1585	a contributory factor	1565:1585	a contributory factor	1565:1585	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	9	40	theme	crystallization	1517:1531	arg1	inhibition					1498:1507	the superior inhibition	1485:1507	the superior inhibition of CaOx crystallization by PGB relative to PGW	1485:1554	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	2	41	theme	endogenous	417:426	arg1	GAGs					456:459	GAGs	456:459	GAGs	456:459	The possible role of endogenous urinary glycosaminoglycans (GAGs) has not been previously investigated in this context.
34933002	2	41	theme	endogenous	417:426	arg1	glycosaminoglycans					436:453	endogenous urinary glycosaminoglycans	417:453	endogenous urinary glycosaminoglycans (GAGs)	417:460	The possible role of endogenous urinary glycosaminoglycans (GAGs) has not been previously investigated in this context.
34933002	0	42	theme	urinary	52:58	arg1	GAGS					60:63	endogenous urinary GAGS	41:63	endogenous urinary GAGS	41:63	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	5	43	dep	group	1058:1062	arg1	PGW					1073:1075	PGW	1073:1075	PGW	1073:1075	CaOx crystal inhibition was determined in ultrafiltered urinary fractions to which purified GAGS (PG) from each group (PGB and PGW) had been added.
34933002	5	43	dep	group	1058:1062	arg1	PGB					1065:1067	PGB	1065:1067	PGB	1065:1067	CaOx crystal inhibition was determined in ultrafiltered urinary fractions to which purified GAGS (PG) from each group (PGB and PGW) had been added.
34933002	3	44	theme	group	618:622	arg1	CaOx					575:578	CaOx	575:578	CaOx	575:578	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	44	theme	group	618:622	arg1	structure					561:569	structure	561:569	structure	561:569	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	44	theme	group	618:622	arg1	composition					548:558	composition	548:558	composition	548:558	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	44	theme	group	618:622	arg1	concentration					533:545	concentration	533:545	concentration	533:545	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	8	45	theme	greater	1352:1358	arg1	extent					1360:1365	a greater extent	1350:1365	a greater extent than PGW	1350:1374	PGB inhibited crystallization to a greater extent than PGW.
34933002	5	46	theme	ultrafiltered	988:1000	arg1	fractions					1010:1018	ultrafiltered urinary fractions	988:1018	ultrafiltered urinary fractions to which purified GAGS (PG) from each group (PGB and PGW) had been added	988:1091	CaOx crystal inhibition was determined in ultrafiltered urinary fractions to which purified GAGS (PG) from each group (PGB and PGW) had been added.
34933002	4	47	theme	24 h	744:747	arg1	samples					755:761	24 h urine samples	744:761	24 h urine samples	744:761	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	7	48	located	found	1291:1295	arg1	PGB					1300:1302	PGB	1300:1302	PGB	1300:1302	RESULTS Higher concentrations of chondroitin sulfate (CS) were found in PGB than in PGW.
34933002	7	48	located	found	1291:1295	arg1	PGW					1312:1314	PGW	1312:1314	PGW	1312:1314	RESULTS Higher concentrations of chondroitin sulfate (CS) were found in PGB than in PGW.
34933002	7	48	located	found	1291:1295	arg2	concentrations					1243:1256	Higher concentrations	1236:1256	Higher concentrations of chondroitin sulfate (CS)	1236:1284	RESULTS Higher concentrations of chondroitin sulfate (CS) were found in PGB than in PGW.
34933002	4	49	dep	precipitation	815:827	arg1	chromatography					930:943	high performance chromatography	913:943	high performance chromatography	913:943	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	3	50	theme	ultrafiltered	640:652	arg1	urine					654:658	ultrafiltered urine	640:658	ultrafiltered urine of healthy subjects from both groups	640:695	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	4	51	theme	sequential	804:813	arg1	precipitation					815:827	sequential precipitation	804:827	sequential precipitation	804:827	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	1	52	from	population	380:389	arg1	rare					362:365	rare	362:365	rare	362:365	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	3	53	from	structure	561:569	arg1	groups					690:695	both groups	685:695	both groups	685:695	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	53	from	structure	561:569	arg1	urine					654:658	ultrafiltered urine	640:658	ultrafiltered urine of healthy subjects from both groups	640:695	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	54	theme	compounds	627:635	arg1	compounds					627:635	compounds	627:635	compounds	627:635	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	54	theme	compounds	627:635	arg1	group					618:622	this group	613:622	this group of compounds	613:635	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	0	55	theme	unique	184:189	arg1	evidence					191:198	unique evidence	184:198	unique evidence in support of an inhibitory role for this group of compounds	184:259	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	3	56	from	CaOx	575:578	arg1	groups					690:695	both groups	685:695	both groups	685:695	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	56	from	CaOx	575:578	arg1	urine					654:658	ultrafiltered urine	640:658	ultrafiltered urine of healthy subjects from both groups	640:695	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	57	theme	subjects	671:678	arg1	urine					654:658	ultrafiltered urine	640:658	ultrafiltered urine of healthy subjects from both groups	640:695	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	0	58	theme	different	117:125	arg1	rates					138:142	different occurrence rates	117:142	different occurrence rates of kidney stones	117:159	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	3	59	dep	concentration	533:545	arg1	properties					599:608	crystal-inhibiting properties	580:608	crystal-inhibiting properties	580:608	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	4	60	theme	performance	859:869	arg1	chromatography					878:891	high performance liquid chromatography	854:891	high performance liquid chromatography	854:891	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	0	61	from	subjects	82:89	arg1	different					69:77	different	69:77	different	69:77	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	9	62	theme	stronger	1406:1413	arg1	effect					1426:1431	the stronger inhibitory effect	1402:1431	the stronger inhibitory effect of PGB to its higher content of CS	1402:1466	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	0	63	from	different	69:77	arg1	subjects					82:89	subjects	82:89	subjects from two race groups with different occurrence rates of kidney stones	82:159	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	0	64	from	evidence	191:198	arg1	support					203:209	support	203:209	support of an inhibitory role for this group of compounds	203:259	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	0	65	theme	kidney	147:152	arg1	stones					154:159	kidney stones	147:159	kidney stones	147:159	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	9	66	theme	lower	1609:1613	arg1	rate					1632:1635	the lower stone occurrence rate	1605:1635	the lower stone occurrence rate in B	1605:1640	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	4	67	theme	protein	839:845	arg1	assay					847:851	Bradford protein assay	830:851	Bradford protein assay	830:851	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	0	68	from	groups	105:110	arg1	subjects					82:89	subjects	82:89	subjects from two race groups with different occurrence rates of kidney stones	82:159	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	6	69	theme	particle	1154:1161	arg1	counting					1163:1170	particle counting	1154:1170	particle counting	1154:1170	Nucleation, growth and aggregation were measured by Coulter particle counting, spectrophotometric assay and [14C]-oxalate deposition.
34933002	9	70	theme	relative	1540:1547	arg1	PGB					1536:1538	PGB	1536:1538	PGB relative to PGW	1536:1554	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	9	71	theme	PGB	1436:1438	arg1	effect					1426:1431	the stronger inhibitory effect	1402:1431	the stronger inhibitory effect of PGB to its higher content of CS	1402:1466	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	4	72	theme	performance	918:928	arg1	chromatography					930:943	high performance chromatography	913:943	high performance chromatography	913:943	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	9	73	theme	stone	1615:1619	arg1	rate					1632:1635	the lower stone occurrence rate	1605:1635	the lower stone occurrence rate in B	1605:1640	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	4	74	attach	isolated	730:737	arg1	samples					755:761	24 h urine samples	744:761	24 h urine samples	744:761	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	4	74	attach	isolated	730:737	arg2	METHODS					712:718	METHODS	712:718	METHODS	712:718	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	4	74	attach	isolated	730:737	arg2	MATERIALS					698:706	MATERIALS	698:706	MATERIALS	698:706	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	9	75	theme	CS	1465:1466	arg1	content					1454:1460	its higher content	1443:1460	its higher content of CS	1443:1466	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	3	76	from	concentration	533:545	arg1	groups					690:695	both groups	685:695	both groups	685:695	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	76	from	concentration	533:545	arg1	urine					654:658	ultrafiltered urine	640:658	ultrafiltered urine of healthy subjects from both groups	640:695	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	0	77	theme	role	228:231	arg1	support					203:209	support	203:209	support of an inhibitory role for this group of compounds	203:259	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	2	78	theme	glycosaminoglycans	436:453	arg1	role					409:412	The possible role	396:412	The possible role of endogenous urinary glycosaminoglycans (GAGs)	396:460	The possible role of endogenous urinary glycosaminoglycans (GAGs) has not been previously investigated in this context.
34933002	3	79	from	composition	548:558	arg1	groups					690:695	both groups	685:695	both groups	685:695	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	3	79	from	composition	548:558	arg1	urine					654:658	ultrafiltered urine	640:658	ultrafiltered urine of healthy subjects from both groups	640:695	AIM To determine concentration, composition, structure and CaOx crystal-inhibiting properties of this group of compounds in ultrafiltered urine of healthy subjects from both groups.
34933002	7	80	theme	sulfate	1273:1279	arg1	concentrations					1243:1256	Higher concentrations	1236:1256	Higher concentrations of chondroitin sulfate (CS)	1236:1284	RESULTS Higher concentrations of chondroitin sulfate (CS) were found in PGB than in PGW.
34933002	1	81	theme	BACKGROUND	262:271	arg1	CaOx					290:293	CaOx	290:293	CaOx	290:293	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	1	81	theme	BACKGROUND	262:271	arg1	oxalate					281:287	BACKGROUND Calcium oxalate	262:287	BACKGROUND Calcium oxalate (CaOx) kidney stone disease	262:315	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	0	82	theme	endogenous	41:50	arg1	GAGS					60:63	endogenous urinary GAGS	41:63	endogenous urinary GAGS	41:63	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	1	83	theme	oxalate	281:287	arg1	disease					309:315	BACKGROUND Calcium oxalate (CaOx) kidney stone disease	262:315	BACKGROUND Calcium oxalate (CaOx) kidney stone disease	262:315	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	9	84	theme	CaOx	1512:1515	arg1	crystallization					1517:1531	CaOx crystallization	1512:1531	CaOx crystallization	1512:1531	CONCLUSIONS We attribute the stronger inhibitory effect of PGB to its higher content of CS and suggest that the superior inhibition of CaOx crystallization by PGB relative to PGW might be a contributory factor in accounting for the lower stone occurrence rate in B.
34933002	7	85	theme	Higher	1236:1241	arg1	concentrations					1243:1256	Higher concentrations	1236:1256	Higher concentrations of chondroitin sulfate (CS)	1236:1284	RESULTS Higher concentrations of chondroitin sulfate (CS) were found in PGB than in PGW.
34933002	4	86	theme	urine	749:753	arg1	samples					755:761	24 h urine samples	744:761	24 h urine samples	744:761	MATERIALS AND METHODS GAGS were isolated from 24 h urine samples and were quantified and characterized by sequential precipitation, Bradford protein assay, high performance liquid chromatography, and anion exchange high performance chromatography.
34933002	0	87	theme	GAGS	60:63	arg1	Composition					0:10	Composition	0:10	Composition	0:10	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	0	87	theme	GAGS	60:63	arg1	properties					27:36	inhibitory properties	16:36	inhibitory properties	16:36	Composition and inhibitory properties of endogenous urinary GAGS are different in subjects from two race groups with different occurrence rates of kidney stones: Pilot studies provide unique evidence in support of an inhibitory role for this group of compounds.
34933002	5	88	theme	urinary	1002:1008	arg1	fractions					1010:1018	ultrafiltered urinary fractions	988:1018	ultrafiltered urinary fractions to which purified GAGS (PG) from each group (PGB and PGW) had been added	988:1091	CaOx crystal inhibition was determined in ultrafiltered urinary fractions to which purified GAGS (PG) from each group (PGB and PGW) had been added.
34933002	1	89	theme	kidney	296:301	arg1	disease					309:315	BACKGROUND Calcium oxalate (CaOx) kidney stone disease	262:315	BACKGROUND Calcium oxalate (CaOx) kidney stone disease	262:315	BACKGROUND Calcium oxalate (CaOx) kidney stone disease is common in South African whites (W) but is rare in the black population (B).
34933002	5	90	theme	crystal	951:957	arg1	inhibition					959:968	CaOx crystal inhibition	946:968	CaOx crystal inhibition	946:968	CaOx crystal inhibition was determined in ultrafiltered urinary fractions to which purified GAGS (PG) from each group (PGB and PGW) had been added.
34933002	7	91	dep	RESULTS	1228:1234	arg1	found					1291:1295	found	1291:1295	were found in PGB than in PGW	1286:1314	RESULTS Higher concentrations of chondroitin sulfate (CS) were found in PGB than in PGW.
32339591	3	0	from	decrease	377:384	arg1	size					398:401	pore size	393:401	pore size	393:401	SEM micrographs showed a decrease in the pore size and porosity of chitosan/pectin/ZnO films when increasing the content of ZnO NPs.
32339591	3	0	from	decrease	377:384	arg1	porosity					407:414	porosity	407:414	porosity	407:414	SEM micrographs showed a decrease in the pore size and porosity of chitosan/pectin/ZnO films when increasing the content of ZnO NPs.
32339591	3	1	theme	ZnO	476:478	arg1	NPs					480:482	ZnO NPs	476:482	ZnO NPs	476:482	SEM micrographs showed a decrease in the pore size and porosity of chitosan/pectin/ZnO films when increasing the content of ZnO NPs.
32339591	4	2	theme	water	539:543	arg1	retention					545:553	water retention	539:553	water retention	539:553	The developed films presented the swelling degree and water retention ability in the range of 189-465 and 230-390%, respectively.
32339591	7	3	theme	CPZnO-2	937:943	arg1	films					945:949	CPZnO-2 films	937:949	CPZnO-2 films	937:949	Among the developed chitosan/pectin/ZnO films, CPZnO-2 films presented the increased rate of cell proliferation and migration.
32339591	8	4	theme	antimicrobial	1038:1050	arg1	activity					1052:1059	antimicrobial activity	1038:1059	antimicrobial activity against the gram-positive and gram-negative bacteria and fungi	1038:1122	Also, they exhibited antimicrobial activity against the gram-positive and gram-negative bacteria and fungi.
32339591	7	5	theme	increased	965:973	arg1	rate					975:978	the increased rate	961:978	the increased rate of cell proliferation and migration	961:1014	Among the developed chitosan/pectin/ZnO films, CPZnO-2 films presented the increased rate of cell proliferation and migration.
32339591	2	6	theme	films	291:295	arg1	morphology					271:280	morphology	271:280	morphology	271:280	The chemical nature, composition and morphology of these films were revealed by FTIR, XRD, EDX, SEM and BET analysis.
32339591	2	6	theme	films	291:295	arg1	composition					255:265	composition	255:265	composition	255:265	The chemical nature, composition and morphology of these films were revealed by FTIR, XRD, EDX, SEM and BET analysis.
32339591	2	6	theme	films	291:295	arg1	nature					247:252	The chemical nature	234:252	The chemical nature	234:252	The chemical nature, composition and morphology of these films were revealed by FTIR, XRD, EDX, SEM and BET analysis.
32339591	4	7	attach	presented	505:513	arg1	range					570:574	the range	566:574	the range of 189-465 and 230-390%	566:598	The developed films presented the swelling degree and water retention ability in the range of 189-465 and 230-390%, respectively.
32339591	4	7	attach	presented	505:513	arg2	films					499:503	The developed films	485:503	The developed films	485:503	The developed films presented the swelling degree and water retention ability in the range of 189-465 and 230-390%, respectively.
32339591	4	8	dep	degree	528:533	arg1	ability					555:561	ability	555:561	ability	555:561	The developed films presented the swelling degree and water retention ability in the range of 189-465 and 230-390%, respectively.
32339591	5	9	theme	lysozyme-containing	704:722	arg1	medium					724:729	the lysozyme-containing medium	700:729	the lysozyme-containing medium	700:729	Moreover, they showed an improved compression strength and controlled degradation in the lysozyme-containing medium in comparison with control.
32339591	9	10	theme	wound	1224:1228	arg1	healing					1230:1236	wound healing	1224:1236	wound healing	1224:1236	These results suggested that chitosan/pectin/ZnO films could be safe, convenient and effective for wound healing.
32339591	1	11	theme	Three-dimensional	88:104	arg1	films					118:122	Three-dimensional (3D) porous films	88:122	Three-dimensional (3D) porous films based on chitosan/pectin/ZnO nanoparticles (NPs)	88:171	Three-dimensional (3D) porous films based on chitosan/pectin/ZnO nanoparticles (NPs) were prepared for wound healing by the freeze-drying method.
32339591	3	12	theme	SEM	352:354	arg1	micrographs					356:366	SEM micrographs	352:366	SEM micrographs	352:366	SEM micrographs showed a decrease in the pore size and porosity of chitosan/pectin/ZnO films when increasing the content of ZnO NPs.
32339591	8	13	theme	gram-positive	1073:1085	arg1	bacteria					1105:1112	bacteria	1105:1112	bacteria	1105:1112	Also, they exhibited antimicrobial activity against the gram-positive and gram-negative bacteria and fungi.
32339591	6	14	theme	MTT	759:761	arg1	assay					763:767	MTT assay	759:767	MTT assay	759:767	MTT assay demonstrated the biocompatibility of chitosan/pectin/ZnO films against the primary human dermal fibroblast cells (HFCs).
32339591	4	15	theme	swelling	519:526	arg1	degree					528:533	the swelling degree	515:533	the swelling degree	515:533	The developed films presented the swelling degree and water retention ability in the range of 189-465 and 230-390%, respectively.
32339591	6	16	theme	chitosan/pectin/ZnO	806:824	arg1	films					826:830	chitosan/pectin/ZnO films	806:830	chitosan/pectin/ZnO films against the primary human dermal fibroblast cells (HFCs)	806:887	MTT assay demonstrated the biocompatibility of chitosan/pectin/ZnO films against the primary human dermal fibroblast cells (HFCs).
32339591	7	17	theme	chitosan/pectin/ZnO	910:928	arg1	films					930:934	the developed chitosan/pectin/ZnO films	896:934	the developed chitosan/pectin/ZnO films	896:934	Among the developed chitosan/pectin/ZnO films, CPZnO-2 films presented the increased rate of cell proliferation and migration.
32339591	3	18	theme	pore	393:396	arg1	size					398:401	pore size	393:401	pore size	393:401	SEM micrographs showed a decrease in the pore size and porosity of chitosan/pectin/ZnO films when increasing the content of ZnO NPs.
32339591	5	19	theme	compression	649:659	arg1	strength					661:668	an improved compression strength	637:668	an improved compression strength	637:668	Moreover, they showed an improved compression strength and controlled degradation in the lysozyme-containing medium in comparison with control.
32339591	8	20	dep	bacteria	1105:1112	arg1	the					1069:1071	the	1069:1071	the	1069:1071	Also, they exhibited antimicrobial activity against the gram-positive and gram-negative bacteria and fungi.
32339591	3	21	theme	chitosan/pectin/ZnO	419:437	arg1	films					439:443	chitosan/pectin/ZnO films	419:443	chitosan/pectin/ZnO films	419:443	SEM micrographs showed a decrease in the pore size and porosity of chitosan/pectin/ZnO films when increasing the content of ZnO NPs.
32339591	2	22	theme	BET	338:340	arg1	analysis					342:349	BET analysis	338:349	BET analysis	338:349	The chemical nature, composition and morphology of these films were revealed by FTIR, XRD, EDX, SEM and BET analysis.
32339591	6	23	theme	fibroblast	865:874	arg1	HFCs					883:886	HFCs	883:886	HFCs	883:886	MTT assay demonstrated the biocompatibility of chitosan/pectin/ZnO films against the primary human dermal fibroblast cells (HFCs).
32339591	6	23	theme	fibroblast	865:874	arg1	cells					876:880	the primary human dermal fibroblast cells	840:880	the primary human dermal fibroblast cells (HFCs)	840:887	MTT assay demonstrated the biocompatibility of chitosan/pectin/ZnO films against the primary human dermal fibroblast cells (HFCs).
32339591	1	24	theme	porous	111:116	arg1	films					118:122	Three-dimensional (3D) porous films	88:122	Three-dimensional (3D) porous films based on chitosan/pectin/ZnO nanoparticles (NPs)	88:171	Three-dimensional (3D) porous films based on chitosan/pectin/ZnO nanoparticles (NPs) were prepared for wound healing by the freeze-drying method.
32339591	7	25	dep	cell	983:986	arg1	migration					1006:1014	migration	1006:1014	migration	1006:1014	Among the developed chitosan/pectin/ZnO films, CPZnO-2 films presented the increased rate of cell proliferation and migration.
32339591	7	25	dep	cell	983:986	arg1	proliferation					988:1000	proliferation	988:1000	proliferation	988:1000	Among the developed chitosan/pectin/ZnO films, CPZnO-2 films presented the increased rate of cell proliferation and migration.
32339591	3	26	theme	films	439:443	arg1	size					398:401	pore size	393:401	pore size	393:401	SEM micrographs showed a decrease in the pore size and porosity of chitosan/pectin/ZnO films when increasing the content of ZnO NPs.
32339591	3	26	theme	films	439:443	arg1	porosity					407:414	porosity	407:414	porosity	407:414	SEM micrographs showed a decrease in the pore size and porosity of chitosan/pectin/ZnO films when increasing the content of ZnO NPs.
32339591	0	27	theme	porous	56:61	arg1	films					63:67	chitosan/pectin/ZnO porous films	36:67	chitosan/pectin/ZnO porous films	36:67	Preparation and characterization of chitosan/pectin/ZnO porous films for wound healing.
32339591	6	28	theme	dermal	858:863	arg1	HFCs					883:886	HFCs	883:886	HFCs	883:886	MTT assay demonstrated the biocompatibility of chitosan/pectin/ZnO films against the primary human dermal fibroblast cells (HFCs).
32339591	6	28	theme	dermal	858:863	arg1	cells					876:880	the primary human dermal fibroblast cells	840:880	the primary human dermal fibroblast cells (HFCs)	840:887	MTT assay demonstrated the biocompatibility of chitosan/pectin/ZnO films against the primary human dermal fibroblast cells (HFCs).
32339591	2	29	theme	chemical	238:245	arg1	nature					247:252	The chemical nature	234:252	The chemical nature	234:252	The chemical nature, composition and morphology of these films were revealed by FTIR, XRD, EDX, SEM and BET analysis.
32339591	1	30	theme	wound	191:195	arg1	healing					197:203	wound healing	191:203	wound healing	191:203	Three-dimensional (3D) porous films based on chitosan/pectin/ZnO nanoparticles (NPs) were prepared for wound healing by the freeze-drying method.
32339591	0	31	theme	chitosan/pectin/ZnO	36:54	arg1	films					63:67	chitosan/pectin/ZnO porous films	36:67	chitosan/pectin/ZnO porous films	36:67	Preparation and characterization of chitosan/pectin/ZnO porous films for wound healing.
32339591	4	32	theme	developed	489:497	arg1	films					499:503	The developed films	485:503	The developed films	485:503	The developed films presented the swelling degree and water retention ability in the range of 189-465 and 230-390%, respectively.
32339591	5	33	theme	controlled	674:683	arg1	degradation					685:695	controlled degradation	674:695	controlled degradation	674:695	Moreover, they showed an improved compression strength and controlled degradation in the lysozyme-containing medium in comparison with control.
32339591	6	34	theme	human	852:856	arg1	HFCs					883:886	HFCs	883:886	HFCs	883:886	MTT assay demonstrated the biocompatibility of chitosan/pectin/ZnO films against the primary human dermal fibroblast cells (HFCs).
32339591	6	34	theme	human	852:856	arg1	cells					876:880	the primary human dermal fibroblast cells	840:880	the primary human dermal fibroblast cells (HFCs)	840:887	MTT assay demonstrated the biocompatibility of chitosan/pectin/ZnO films against the primary human dermal fibroblast cells (HFCs).
32339591	1	35	theme	freeze-drying	212:224	arg1	method					226:231	the freeze-drying method	208:231	the freeze-drying method	208:231	Three-dimensional (3D) porous films based on chitosan/pectin/ZnO nanoparticles (NPs) were prepared for wound healing by the freeze-drying method.
32339591	6	36	theme	primary	844:850	arg1	HFCs					883:886	HFCs	883:886	HFCs	883:886	MTT assay demonstrated the biocompatibility of chitosan/pectin/ZnO films against the primary human dermal fibroblast cells (HFCs).
32339591	6	36	theme	primary	844:850	arg1	cells					876:880	the primary human dermal fibroblast cells	840:880	the primary human dermal fibroblast cells (HFCs)	840:887	MTT assay demonstrated the biocompatibility of chitosan/pectin/ZnO films against the primary human dermal fibroblast cells (HFCs).
32339591	3	37	dep	size	398:401	arg1	the					389:391	the	389:391	the	389:391	SEM micrographs showed a decrease in the pore size and porosity of chitosan/pectin/ZnO films when increasing the content of ZnO NPs.
32339591	0	38	theme	films	63:67	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of chitosan/pectin/ZnO porous films for wound healing.
32339591	0	38	theme	films	63:67	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of chitosan/pectin/ZnO porous films for wound healing.
32339591	8	39	theme	gram-negative	1091:1103	arg1	bacteria					1105:1112	bacteria	1105:1112	bacteria	1105:1112	Also, they exhibited antimicrobial activity against the gram-positive and gram-negative bacteria and fungi.
32339591	9	40	theme	chitosan/pectin/ZnO	1154:1172	arg1	films					1174:1178	chitosan/pectin/ZnO films	1154:1178	chitosan/pectin/ZnO films	1154:1178	These results suggested that chitosan/pectin/ZnO films could be safe, convenient and effective for wound healing.
32339591	1	41	dep	Three-dimensional	88:104	arg1	3D					107:108	3D	107:108	3D	107:108	Three-dimensional (3D) porous films based on chitosan/pectin/ZnO nanoparticles (NPs) were prepared for wound healing by the freeze-drying method.
32339591	5	42	with	comparison	734:743	arg1	control					750:756	control	750:756	control	750:756	Moreover, they showed an improved compression strength and controlled degradation in the lysozyme-containing medium in comparison with control.
32339591	7	43	theme	developed	900:908	arg1	films					930:934	the developed chitosan/pectin/ZnO films	896:934	the developed chitosan/pectin/ZnO films	896:934	Among the developed chitosan/pectin/ZnO films, CPZnO-2 films presented the increased rate of cell proliferation and migration.
32339591	5	44	theme	improved	640:647	arg1	strength					661:668	an improved compression strength	637:668	an improved compression strength	637:668	Moreover, they showed an improved compression strength and controlled degradation in the lysozyme-containing medium in comparison with control.
32339591	6	45	theme	films	826:830	arg1	biocompatibility					786:801	the biocompatibility	782:801	the biocompatibility of chitosan/pectin/ZnO films against the primary human dermal fibroblast cells (HFCs)	782:887	MTT assay demonstrated the biocompatibility of chitosan/pectin/ZnO films against the primary human dermal fibroblast cells (HFCs).
32339591	7	46	theme	cell	983:986	arg1	rate					975:978	the increased rate	961:978	the increased rate of cell proliferation and migration	961:1014	Among the developed chitosan/pectin/ZnO films, CPZnO-2 films presented the increased rate of cell proliferation and migration.
32339591	1	47	theme	chitosan/pectin/ZnO	133:151	arg1	NPs					168:170	NPs	168:170	NPs	168:170	Three-dimensional (3D) porous films based on chitosan/pectin/ZnO nanoparticles (NPs) were prepared for wound healing by the freeze-drying method.
32339591	1	47	theme	chitosan/pectin/ZnO	133:151	arg1	nanoparticles					153:165	chitosan/pectin/ZnO nanoparticles	133:165	chitosan/pectin/ZnO nanoparticles (NPs)	133:171	Three-dimensional (3D) porous films based on chitosan/pectin/ZnO nanoparticles (NPs) were prepared for wound healing by the freeze-drying method.
32339591	4	48	theme	%	598:598	arg1	range					570:574	the range	566:574	the range of 189-465 and 230-390%	566:598	The developed films presented the swelling degree and water retention ability in the range of 189-465 and 230-390%, respectively.
32339591	3	49	theme	NPs	480:482	arg1	content					465:471	the content	461:471	the content of ZnO NPs	461:482	SEM micrographs showed a decrease in the pore size and porosity of chitosan/pectin/ZnO films when increasing the content of ZnO NPs.
32339591	0	50	theme	wound	73:77	arg1	healing					79:85	wound healing	73:85	wound healing	73:85	Preparation and characterization of chitosan/pectin/ZnO porous films for wound healing.
34272488	8	0	theme	early	933:937	arg1	loss					946:949	very early memory loss	928:949	very early memory loss	928:949	These animals showed very early memory loss at 11 weeks old.
34272488	7	1	theme	permissive	867:876	arg1	C6S					878:880	permissive C6S	867:880	permissive C6S	867:880	Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains.
34272488	1	2	theme	neuronal	169:176	arg1	surface					178:184	the neuronal surface	165:184	the neuronal surface	165:184	Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
34272488	0	3	from	memory	59:64	arg1	ageing					69:74	ageing	69:74	ageing	69:74	Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing.
34272488	5	4	theme	cognitive	653:661	arg1	ability					663:669	their cognitive ability	647:669	their cognitive ability	647:669	They were able to retain or regain their cognitive ability when CSs were digested or PNNs were attenuated.
34272488	1	5	from	structures	151:160	arg1	surface					178:184	the neuronal surface	165:184	the neuronal surface	165:184	Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
34272488	9	6	theme	memory	1030:1035	arg1	deficits					1037:1044	the memory deficits	1026:1044	the memory deficits	1026:1044	Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.
34272488	4	7	theme	memory	580:585	arg1	deficits					602:609	memory and plasticity deficits	580:609	memory and plasticity deficits	580:609	We first confirmed that aged mice (20-months) showed memory and plasticity deficits.
34272488	2	8	theme	6-sulphates	295:305	arg1	reduction					270:278	Age-related reduction	258:278	Age-related reduction of chondroitin 6-sulphates (C6S)	258:311	Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory.
34272488	0	9	from	neuroplasticity	39:53	arg1	ageing					69:74	ageing	69:74	ageing	69:74	Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing.
34272488	1	10	theme	Perineuronal	77:88	arg1	PNNs					96:99	PNNs	96:99	PNNs	96:99	Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
34272488	1	10	theme	Perineuronal	77:88	arg1	structures					151:160	chondroitin sulphate proteoglycan-containing structures	106:160	chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory	106:255	Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
34272488	1	10	theme	Perineuronal	77:88	arg1	nets					90:93	Perineuronal nets	77:93	Perineuronal nets (PNNs)	77:100	Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
34272488	8	11	theme	old	963:965	arg1	weeks					957:961	11 weeks old	954:965	11 weeks old	954:965	These animals showed very early memory loss at 11 weeks old.
34272488	0	12	theme	Chondroitin	0:10	arg1	6-sulphate					12:21	Chondroitin 6-sulphate	0:21	Chondroitin 6-sulphate	0:21	Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing.
34272488	7	13	theme	Transgenic	783:792	arg1	deletion					794:801	Transgenic deletion	783:801	Transgenic deletion of chondroitin 6-sulfotransferase (chst3)	783:843	Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains.
34272488	6	14	from	role	740:743	arg1	memory					755:760	memory	755:760	memory	755:760	We then explored the role of C6S in memory and neuroplasticity.
34272488	6	14	from	role	740:743	arg1	neuroplasticity					766:780	neuroplasticity	766:780	neuroplasticity	766:780	We then explored the role of C6S in memory and neuroplasticity.
34272488	7	15	theme	6-sulfotransferase	818:835	arg1	deletion					794:801	Transgenic deletion	783:801	Transgenic deletion of chondroitin 6-sulfotransferase (chst3)	783:843	Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains.
34272488	3	16	theme	composition	429:439	arg1	manipulation					383:394	manipulation	383:394	manipulation of the chondroitin sulphate (CS) composition of the PNNs	383:451	Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice.
34272488	4	17	theme	plasticity	591:600	arg1	deficits					602:609	memory and plasticity deficits	580:609	memory and plasticity deficits	580:609	We first confirmed that aged mice (20-months) showed memory and plasticity deficits.
34272488	4	18	theme	aged	551:554	arg1	mice					556:559	aged mice	551:559	aged mice (20-months)	551:571	We first confirmed that aged mice (20-months) showed memory and plasticity deficits.
34272488	4	18	theme	aged	551:554	arg1	20-months					562:570	20-months	562:570	20-months	562:570	We first confirmed that aged mice (20-months) showed memory and plasticity deficits.
34272488	3	19	from	deficits	504:511	arg1	mice					521:524	aged mice	516:524	aged mice	516:524	Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice.
34272488	9	20	theme	long-term	1068:1076	arg1	potentiation					1078:1089	cortical long-term potentiation	1059:1089	cortical long-term potentiation	1059:1089	Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.
34272488	3	21	theme	aged	516:519	arg1	mice					521:524	aged mice	516:524	aged mice	516:524	Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice.
34272488	9	22	theme	cortical	1059:1066	arg1	potentiation					1078:1089	cortical long-term potentiation	1059:1089	cortical long-term potentiation	1059:1089	Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.
34272488	7	23	theme	chondroitin	806:816	arg1	6-sulfotransferase					818:835	chondroitin 6-sulfotransferase	806:835	chondroitin 6-sulfotransferase (chst3)	806:843	Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains.
34272488	7	23	theme	chondroitin	806:816	arg1	chst3					838:842	chst3	838:842	chst3	838:842	Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains.
34272488	3	24	theme	PNNs	448:451	arg1	composition					429:439	the chondroitin sulphate (CS) composition	399:439	the chondroitin sulphate (CS) composition of the PNNs	399:451	Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice.
34272488	3	25	theme	chondroitin	403:413	arg1	sulphate					415:422	chondroitin sulphate	403:422	the chondroitin sulphate (CS) composition of the PNNs	399:451	Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice.
34272488	3	25	theme	chondroitin	403:413	arg1	CS					425:426	CS	425:426	CS	425:426	Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice.
34272488	3	26	theme	memory	497:502	arg1	deficits					504:511	memory deficits	497:511	memory deficits in aged mice	497:524	Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice.
34272488	3	27	theme	sulphate	415:422	arg1	composition					429:439	the chondroitin sulphate (CS) composition	399:439	the chondroitin sulphate (CS) composition of the PNNs	399:451	Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice.
34272488	1	28	theme	chondroitin	106:116	arg1	nets					90:93	Perineuronal nets	77:93	Perineuronal nets (PNNs)	77:100	Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
34272488	1	28	theme	chondroitin	106:116	arg1	structures					151:160	chondroitin sulphate proteoglycan-containing structures	106:160	chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory	106:255	Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
34272488	6	29	theme	C6S	748:750	arg1	role					740:743	the role	736:743	the role of C6S in memory and neuroplasticity	736:780	We then explored the role of C6S in memory and neuroplasticity.
34272488	1	30	theme	sulphate	118:125	arg1	nets					90:93	Perineuronal nets	77:93	Perineuronal nets (PNNs)	77:100	Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
34272488	1	30	theme	sulphate	118:125	arg1	structures					151:160	chondroitin sulphate proteoglycan-containing structures	106:160	chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory	106:255	Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
34272488	7	31	theme	aged	894:897	arg1	brains					899:904	aged brains	894:904	aged brains	894:904	Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains.
34272488	2	32	theme	chondroitin	283:293	arg1	C6S					308:310	C6S	308:310	C6S	308:310	Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory.
34272488	2	32	theme	chondroitin	283:293	arg1	6-sulphates					295:305	chondroitin 6-sulphates	283:305	chondroitin 6-sulphates (C6S)	283:311	Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory.
34272488	9	33	theme	memory	1137:1142	arg1	impairment					1144:1153	age-related memory impairment	1125:1153	age-related memory impairment	1125:1153	Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.
34272488	1	34	theme	proteoglycan-containing	127:149	arg1	nets					90:93	Perineuronal nets	77:93	Perineuronal nets (PNNs)	77:100	Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
34272488	1	34	theme	proteoglycan-containing	127:149	arg1	structures					151:160	chondroitin sulphate proteoglycan-containing structures	106:160	chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory	106:255	Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
34272488	7	35	theme	C6S	878:880	arg1	reduction					854:862	a reduction	852:862	a reduction of permissive C6S	852:880	Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains.
34272488	1	36	theme	neuroplasticity	230:244	arg1	control					219:225	the control	215:225	the control of neuroplasticity and memory	215:255	Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
34272488	2	37	theme	Age-related	258:268	arg1	reduction					270:278	Age-related reduction	258:278	Age-related reduction of chondroitin 6-sulphates (C6S)	258:311	Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory.
34272488	9	38	theme	age-related	1125:1135	arg1	impairment					1144:1153	age-related memory impairment	1125:1153	age-related memory impairment	1125:1153	Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.
34272488	9	39	theme	C6S	991:993	arg1	levels					995:1000	C6S levels	991:1000	C6S levels	991:1000	Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.
34272488	8	40	theme	memory	939:944	arg1	loss					946:949	very early memory loss	928:949	very early memory loss	928:949	These animals showed very early memory loss at 11 weeks old.
34272488	9	41	theme	aged	1005:1008	arg1	animals					1010:1016	aged animals	1005:1016	aged animals	1005:1016	Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.
34272488	1	42	theme	memory	250:255	arg1	control					219:225	the control	215:225	the control of neuroplasticity and memory	215:255	Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory.
33394084	0	0	theme	Capable	78:84	arg1	Enzyme					137:142	Capable of Producing Galacto-oligosaccharides Synthesising Enzyme	78:142	Capable of Producing Galacto-oligosaccharides Synthesising Enzyme	78:142	Draft Genome Sequence of a Highly Pigmented Bacterium Paracoccus marcusii KGP Capable of Producing Galacto-oligosaccharides Synthesising Enzyme.
33394084	6	1	theme	genome	1001:1006	arg1	sequence					1008:1015	The genome sequence	997:1015	The genome sequence of P. marcusii KGP	997:1034	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	5	2	theme	high	862:865	arg1	concentration					867:879	a high concentration	860:879	a high concentration of lactose	860:890	When the β-galactosidase extracted from P. marcusii KGP was mixed with a high concentration of lactose, galacto-oligosaccharides were produced, which revealed the transgalactosylation property of the enzyme.
33394084	1	3	theme	Bay	250:252	arg1	coast					237:241	the coast	233:241	the coast of the Bay of Bengal	233:262	The genome of Paracoccus marcusii KGP, isolated from the marine sediment collected from the coast of the Bay of Bengal, was sequenced using Oxford Nanopore sequencing technology.
33394084	2	4	theme	%	471:471	arg1	content					456:462	a G+C content	450:462	a G+C content of 66.7%	450:471	The assembled genome sequence consists of seven contigs and has a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%.
33394084	2	4	theme	%	471:471	arg1	genes					440:444	1647 coding genes	428:444	1647 coding genes	428:444	The assembled genome sequence consists of seven contigs and has a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%.
33394084	6	5	contain	have	1049:1052	arg2	value					1085:1089	an average nucleotide identity value	1054:1089	an average nucleotide identity value of 96.16	1054:1098	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	6	5	contain	have	1049:1052	arg1	sequence					1008:1015	The genome sequence	997:1015	The genome sequence of P. marcusii KGP	997:1034	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	6	5	contain	have	1049:1052	arg2	value					1136:1140	a digital DNA-DNA hybridisation value	1104:1140	a digital DNA-DNA hybridisation value of 73.90%	1104:1150	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	7	6	theme	strain-specific	1349:1363	arg1	genes					1365:1369	strain-specific genes	1349:1369	strain-specific genes	1349:1369	Furthermore, by comparing the genome sequences of both strains, it was found that the size of the KGP genome was large, indicating the possibility of strain-specific genes in addition to core genes.
33394084	6	7	theme	identity	1076:1083	arg1	value					1085:1089	an average nucleotide identity value	1054:1089	an average nucleotide identity value of 96.16	1054:1098	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	1	8	theme	KGP	179:181	arg1	genome					149:154	The genome	145:154	The genome of Paracoccus marcusii KGP, isolated from the marine sediment collected from the coast of the Bay of Bengal,	145:263	The genome of Paracoccus marcusii KGP, isolated from the marine sediment collected from the coast of the Bay of Bengal, was sequenced using Oxford Nanopore sequencing technology.
33394084	6	9	theme	nucleotide	1065:1074	arg1	value					1085:1089	an average nucleotide identity value	1054:1089	an average nucleotide identity value of 96.16	1054:1098	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	6	10	theme	marcusii	1183:1190	arg1	CGMCC					1192:1196	P. marcusii CGMCC	1180:1196	P. marcusii CGMCC	1180:1196	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	4	11	theme	biosynthesis	731:742	arg1	clusters					744:751	carotenoid biosynthesis clusters	720:751	carotenoid biosynthesis clusters	720:751	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	6	12	theme	marcusii	1023:1030	arg1	KGP					1032:1034	P. marcusii KGP	1020:1034	P. marcusii KGP	1020:1034	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	1	13	theme	Bengal	257:262	arg1	Bay					250:252	the Bay	246:252	the Bay of Bengal	246:262	The genome of Paracoccus marcusii KGP, isolated from the marine sediment collected from the coast of the Bay of Bengal, was sequenced using Oxford Nanopore sequencing technology.
33394084	2	14	with	chromosome	412:421	arg1	content					456:462	a G+C content	450:462	a G+C content of 66.7%	450:471	The assembled genome sequence consists of seven contigs and has a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%.
33394084	2	14	with	chromosome	412:421	arg1	genes					440:444	1647 coding genes	428:444	1647 coding genes	428:444	The assembled genome sequence consists of seven contigs and has a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%.
33394084	6	15	theme	%	1150:1150	arg1	value					1136:1140	a digital DNA-DNA hybridisation value	1104:1140	a digital DNA-DNA hybridisation value of 73.90%	1104:1150	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	6	15	theme	%	1150:1150	arg1	value					1085:1089	an average nucleotide identity value	1054:1089	an average nucleotide identity value of 96.16	1054:1098	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	4	16	theme	carotenoid	720:729	arg1	clusters					744:751	carotenoid biosynthesis clusters	720:751	carotenoid biosynthesis clusters	720:751	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	7	17	theme	genome	1229:1234	arg1	sequences					1236:1244	the genome sequences	1225:1244	the genome sequences of both strains	1225:1260	Furthermore, by comparing the genome sequences of both strains, it was found that the size of the KGP genome was large, indicating the possibility of strain-specific genes in addition to core genes.
33394084	0	18	theme	Synthesising	124:135	arg1	Enzyme					137:142	Capable of Producing Galacto-oligosaccharides Synthesising Enzyme	78:142	Capable of Producing Galacto-oligosaccharides Synthesising Enzyme	78:142	Draft Genome Sequence of a Highly Pigmented Bacterium Paracoccus marcusii KGP Capable of Producing Galacto-oligosaccharides Synthesising Enzyme.
33394084	6	19	theme	KGP	1032:1034	arg1	sequence					1008:1015	The genome sequence	997:1015	The genome sequence of P. marcusii KGP	997:1034	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	3	20	theme	marcusii	500:507	arg1	KGP					509:511	P. marcusii KGP	497:511	P. marcusii KGP	497:511	Besides, the genome of P. marcusii KGP contains three copies of the rrn operon.
33394084	2	21	theme	4,085,678 bp	390:401	arg1	chromosome					412:421	a 4,085,678 bp circular chromosome	388:421	a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%	388:471	The assembled genome sequence consists of seven contigs and has a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%.
33394084	0	22	theme	Pigmented	34:42	arg1	Bacterium					44:52	a Highly Pigmented Bacterium	25:52	a Highly Pigmented Bacterium Paracoccus marcusii	25:72	Draft Genome Sequence of a Highly Pigmented Bacterium Paracoccus marcusii KGP Capable of Producing Galacto-oligosaccharides Synthesising Enzyme.
33394084	3	23	theme	KGP	509:511	arg1	genome					487:492	the genome	483:492	the genome of P. marcusii KGP	483:511	Besides, the genome of P. marcusii KGP contains three copies of the rrn operon.
33394084	6	24	theme	average	1057:1063	arg1	value					1085:1089	an average nucleotide identity value	1054:1089	an average nucleotide identity value of 96.16	1054:1098	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	0	25	theme	Genome	6:11	arg1	Sequence					13:20	Draft Genome Sequence	0:20	Draft Genome Sequence of a Highly Pigmented Bacterium Paracoccus marcusii	0:72	Draft Genome Sequence of a Highly Pigmented Bacterium Paracoccus marcusii KGP Capable of Producing Galacto-oligosaccharides Synthesising Enzyme.
33394084	7	26	theme	core	1386:1389	arg1	genes					1391:1395	core genes	1386:1395	core genes	1386:1395	Furthermore, by comparing the genome sequences of both strains, it was found that the size of the KGP genome was large, indicating the possibility of strain-specific genes in addition to core genes.
33394084	0	27	theme	Draft	0:4	arg1	Sequence					13:20	Draft Genome Sequence	0:20	Draft Genome Sequence of a Highly Pigmented Bacterium Paracoccus marcusii	0:72	Draft Genome Sequence of a Highly Pigmented Bacterium Paracoccus marcusii KGP Capable of Producing Galacto-oligosaccharides Synthesising Enzyme.
33394084	3	28	theme	rrn	542:544	arg1	operon					546:551	the rrn operon	538:551	the rrn operon	538:551	Besides, the genome of P. marcusii KGP contains three copies of the rrn operon.
33394084	7	29	theme	genome	1301:1306	arg1	size					1285:1288	the size	1281:1288	the size of the KGP genome	1281:1306	Furthermore, by comparing the genome sequences of both strains, it was found that the size of the KGP genome was large, indicating the possibility of strain-specific genes in addition to core genes.
33394084	7	29	theme	genome	1301:1306	arg1	large					1312:1316	large	1312:1316	large	1312:1316	Furthermore, by comparing the genome sequences of both strains, it was found that the size of the KGP genome was large, indicating the possibility of strain-specific genes in addition to core genes.
33394084	6	30	theme	genome	1161:1166	arg1	sequence					1168:1175	the genome sequence	1157:1175	the genome sequence of P. marcusii CGMCC	1157:1196	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	6	31	theme	DNA-DNA	1114:1120	arg1	value					1136:1140	a digital DNA-DNA hybridisation value	1104:1140	a digital DNA-DNA hybridisation value of 73.90%	1104:1150	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	2	32	theme	1647	428:431	arg1	genes					440:444	1647 coding genes	428:444	1647 coding genes	428:444	The assembled genome sequence consists of seven contigs and has a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%.
33394084	2	33	theme	coding	433:438	arg1	genes					440:444	1647 coding genes	428:444	1647 coding genes	428:444	The assembled genome sequence consists of seven contigs and has a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%.
33394084	5	34	theme	transgalactosylation	952:971	arg1	property					973:980	the transgalactosylation property	948:980	the transgalactosylation property of the enzyme	948:994	When the β-galactosidase extracted from P. marcusii KGP was mixed with a high concentration of lactose, galacto-oligosaccharides were produced, which revealed the transgalactosylation property of the enzyme.
33394084	1	35	attach	isolated	184:191	arg2	KGP					179:181	Paracoccus marcusii KGP	159:181	Paracoccus marcusii KGP	159:181	The genome of Paracoccus marcusii KGP, isolated from the marine sediment collected from the coast of the Bay of Bengal, was sequenced using Oxford Nanopore sequencing technology.
33394084	1	35	attach	isolated	184:191	arg1	sediment					209:216	the marine sediment	198:216	the marine sediment collected from the coast of the Bay of Bengal	198:262	The genome of Paracoccus marcusii KGP, isolated from the marine sediment collected from the coast of the Bay of Bengal, was sequenced using Oxford Nanopore sequencing technology.
33394084	1	36	dep	Paracoccus	159:168	arg1	marcusii					170:177	marcusii	170:177	marcusii	170:177	The genome of Paracoccus marcusii KGP, isolated from the marine sediment collected from the coast of the Bay of Bengal, was sequenced using Oxford Nanopore sequencing technology.
33394084	4	37	theme	relevant	592:599	arg1	β-glucosidase					679:691	β-glucosidase	679:691	β-glucosidase	679:691	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	37	theme	relevant	592:599	arg1	enzymes					601:607	the industrially relevant enzymes	575:607	the industrially relevant enzymes	575:607	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	37	theme	relevant	592:599	arg1	ectoine					694:700	ectoine	694:700	ectoine	694:700	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	37	theme	relevant	592:599	arg1	clusters					744:751	carotenoid biosynthesis clusters	720:751	carotenoid biosynthesis clusters	720:751	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	37	theme	relevant	592:599	arg1	protease					660:667	protease	660:667	protease	660:667	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	37	theme	relevant	592:599	arg1	amylase					670:676	amylase	670:676	amylase	670:676	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	37	theme	relevant	592:599	arg1	indigoidine					703:713	indigoidine	703:713	indigoidine	703:713	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	37	theme	relevant	592:599	arg1	β-galactosidase					643:657	β-galactosidase	643:657	β-galactosidase	643:657	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	7	38	theme	strains	1254:1260	arg1	sequences					1236:1244	the genome sequences	1225:1244	the genome sequences of both strains	1225:1260	Furthermore, by comparing the genome sequences of both strains, it was found that the size of the KGP genome was large, indicating the possibility of strain-specific genes in addition to core genes.
33394084	1	39	theme	Oxford	285:290	arg1	technology					312:321	Oxford Nanopore sequencing technology	285:321	Oxford Nanopore sequencing technology	285:321	The genome of Paracoccus marcusii KGP, isolated from the marine sediment collected from the coast of the Bay of Bengal, was sequenced using Oxford Nanopore sequencing technology.
33394084	2	40	contain	has	384:386	arg2	chromosome					412:421	a 4,085,678 bp circular chromosome	388:421	a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%	388:471	The assembled genome sequence consists of seven contigs and has a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%.
33394084	2	40	contain	has	384:386	arg1	sequence					345:352	The assembled genome sequence	324:352	The assembled genome sequence	324:352	The assembled genome sequence consists of seven contigs and has a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%.
33394084	4	41	theme	secondary	613:621	arg1	β-glucosidase					679:691	β-glucosidase	679:691	β-glucosidase	679:691	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	41	theme	secondary	613:621	arg1	ectoine					694:700	ectoine	694:700	ectoine	694:700	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	41	theme	secondary	613:621	arg1	clusters					744:751	carotenoid biosynthesis clusters	720:751	carotenoid biosynthesis clusters	720:751	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	41	theme	secondary	613:621	arg1	protease					660:667	protease	660:667	protease	660:667	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	41	theme	secondary	613:621	arg1	amylase					670:676	amylase	670:676	amylase	670:676	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	41	theme	secondary	613:621	arg1	indigoidine					703:713	indigoidine	703:713	indigoidine	703:713	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	41	theme	secondary	613:621	arg1	metabolites					623:633	secondary metabolites	613:633	secondary metabolites	613:633	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	4	41	theme	secondary	613:621	arg1	β-galactosidase					643:657	β-galactosidase	643:657	β-galactosidase	643:657	The genes coding for the industrially relevant enzymes and secondary metabolites such as β-galactosidase, protease, amylase, β-glucosidase, ectoine, indigoidine, and carotenoid biosynthesis clusters were also identified in the genome.
33394084	5	42	theme	marcusii	832:839	arg1	KGP					841:843	P. marcusii KGP	829:843	P. marcusii KGP	829:843	When the β-galactosidase extracted from P. marcusii KGP was mixed with a high concentration of lactose, galacto-oligosaccharides were produced, which revealed the transgalactosylation property of the enzyme.
33394084	1	43	theme	Nanopore	292:299	arg1	technology					312:321	Oxford Nanopore sequencing technology	285:321	Oxford Nanopore sequencing technology	285:321	The genome of Paracoccus marcusii KGP, isolated from the marine sediment collected from the coast of the Bay of Bengal, was sequenced using Oxford Nanopore sequencing technology.
33394084	5	44	theme	lactose	884:890	arg1	concentration					867:879	a high concentration	860:879	a high concentration of lactose	860:890	When the β-galactosidase extracted from P. marcusii KGP was mixed with a high concentration of lactose, galacto-oligosaccharides were produced, which revealed the transgalactosylation property of the enzyme.
33394084	2	45	theme	circular	403:410	arg1	chromosome					412:421	a 4,085,678 bp circular chromosome	388:421	a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%	388:471	The assembled genome sequence consists of seven contigs and has a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%.
33394084	0	46	theme	Bacterium	44:52	arg1	Sequence					13:20	Draft Genome Sequence	0:20	Draft Genome Sequence of a Highly Pigmented Bacterium Paracoccus marcusii	0:72	Draft Genome Sequence of a Highly Pigmented Bacterium Paracoccus marcusii KGP Capable of Producing Galacto-oligosaccharides Synthesising Enzyme.
33394084	1	47	theme	sequencing	301:310	arg1	technology					312:321	Oxford Nanopore sequencing technology	285:321	Oxford Nanopore sequencing technology	285:321	The genome of Paracoccus marcusii KGP, isolated from the marine sediment collected from the coast of the Bay of Bengal, was sequenced using Oxford Nanopore sequencing technology.
33394084	6	48	theme	P.	1020:1021	arg1	KGP					1032:1034	P. marcusii KGP	1020:1034	P. marcusii KGP	1020:1034	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	3	49	theme	operon	546:551	arg1	copies					528:533	three copies	522:533	three copies of the rrn operon	522:551	Besides, the genome of P. marcusii KGP contains three copies of the rrn operon.
33394084	2	50	theme	G+C	452:454	arg1	content					456:462	a G+C content	450:462	a G+C content of 66.7%	450:471	The assembled genome sequence consists of seven contigs and has a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%.
33394084	6	51	theme	P.	1180:1181	arg1	CGMCC					1192:1196	P. marcusii CGMCC	1180:1196	P. marcusii CGMCC	1180:1196	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	2	52	theme	genome	338:343	arg1	sequence					345:352	The assembled genome sequence	324:352	The assembled genome sequence	324:352	The assembled genome sequence consists of seven contigs and has a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%.
33394084	3	53	contain	contains	513:520	arg1	genome					487:492	the genome	483:492	the genome of P. marcusii KGP	483:511	Besides, the genome of P. marcusii KGP contains three copies of the rrn operon.
33394084	3	53	contain	contains	513:520	arg2	copies					528:533	three copies	522:533	three copies of the rrn operon	522:551	Besides, the genome of P. marcusii KGP contains three copies of the rrn operon.
33394084	6	54	theme	CGMCC	1192:1196	arg1	sequence					1168:1175	the genome sequence	1157:1175	the genome sequence of P. marcusii CGMCC	1157:1196	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	2	55	theme	assembled	328:336	arg1	sequence					345:352	The assembled genome sequence	324:352	The assembled genome sequence	324:352	The assembled genome sequence consists of seven contigs and has a 4,085,678 bp circular chromosome with 1647 coding genes and a G+C content of 66.7%.
33394084	7	56	theme	genes	1365:1369	arg1	possibility					1334:1344	the possibility	1330:1344	the possibility of strain-specific genes	1330:1369	Furthermore, by comparing the genome sequences of both strains, it was found that the size of the KGP genome was large, indicating the possibility of strain-specific genes in addition to core genes.
33394084	7	57	theme	KGP	1297:1299	arg1	genome					1301:1306	the KGP genome	1293:1306	the KGP genome	1293:1306	Furthermore, by comparing the genome sequences of both strains, it was found that the size of the KGP genome was large, indicating the possibility of strain-specific genes in addition to core genes.
33394084	3	58	theme	P.	497:498	arg1	KGP					509:511	P. marcusii KGP	497:511	P. marcusii KGP	497:511	Besides, the genome of P. marcusii KGP contains three copies of the rrn operon.
33394084	6	59	theme	96.16	1094:1098	arg1	value					1136:1140	a digital DNA-DNA hybridisation value	1104:1140	a digital DNA-DNA hybridisation value of 73.90%	1104:1150	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	6	59	theme	96.16	1094:1098	arg1	value					1085:1089	an average nucleotide identity value	1054:1089	an average nucleotide identity value of 96.16	1054:1098	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	5	60	theme	P.	829:830	arg1	KGP					841:843	P. marcusii KGP	829:843	P. marcusii KGP	829:843	When the β-galactosidase extracted from P. marcusii KGP was mixed with a high concentration of lactose, galacto-oligosaccharides were produced, which revealed the transgalactosylation property of the enzyme.
33394084	5	61	theme	enzyme	989:994	arg1	property					973:980	the transgalactosylation property	948:980	the transgalactosylation property of the enzyme	948:994	When the β-galactosidase extracted from P. marcusii KGP was mixed with a high concentration of lactose, galacto-oligosaccharides were produced, which revealed the transgalactosylation property of the enzyme.
33394084	1	62	theme	marine	202:207	arg1	sediment					209:216	the marine sediment	198:216	the marine sediment collected from the coast of the Bay of Bengal	198:262	The genome of Paracoccus marcusii KGP, isolated from the marine sediment collected from the coast of the Bay of Bengal, was sequenced using Oxford Nanopore sequencing technology.
33394084	6	63	theme	hybridisation	1122:1134	arg1	value					1136:1140	a digital DNA-DNA hybridisation value	1104:1140	a digital DNA-DNA hybridisation value of 73.90%	1104:1150	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	6	64	theme	digital	1106:1112	arg1	value					1136:1140	a digital DNA-DNA hybridisation value	1104:1140	a digital DNA-DNA hybridisation value of 73.90%	1104:1150	The genome sequence of P. marcusii KGP was found to have an average nucleotide identity value of 96.16 and a digital DNA-DNA hybridisation value of 73.90% with the genome sequence of P. marcusii CGMCC.
33394084	1	65	theme	Paracoccus	159:168	arg1	KGP					179:181	Paracoccus marcusii KGP	159:181	Paracoccus marcusii KGP	159:181	The genome of Paracoccus marcusii KGP, isolated from the marine sediment collected from the coast of the Bay of Bengal, was sequenced using Oxford Nanopore sequencing technology.
34980351	0	0	theme	CNF	90:92	arg1	matrix					95:100	cellulose nanofibril (CNF) matrix	68:100	cellulose nanofibril (CNF) matrix	68:100	Recyclable nanocomposites of well-dispersed 2D layered silicates in cellulose nanofibril (CNF) matrix.
34980351	4	1	theme	X-ray	719:723	arg1	diffraction					725:735	X-ray diffraction	719:735	X-ray diffraction	719:735	X-ray diffraction and transmission electron micrographs show almost monolayer dispersion of saponite and montmorillonite and high orientation parallel to the film surface.
34980351	3	2	theme	force	506:510	arg1	filtration					556:565	vacuum-assisted filtration	540:565	vacuum-assisted filtration	540:565	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	2	theme	force	506:510	arg1	assembly					530:537	capillary force assisted physical assembly	496:537	capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica	496:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	4	3	theme	saponite	811:818	arg1	orientation					849:859	high orientation	844:859	high orientation parallel to the film surface	844:888	X-ray diffraction and transmission electron micrographs show almost monolayer dispersion of saponite and montmorillonite and high orientation parallel to the film surface.
34980351	4	3	theme	saponite	811:818	arg1	dispersion					797:806	almost monolayer dispersion	780:806	almost monolayer dispersion of saponite and montmorillonite	780:838	X-ray diffraction and transmission electron micrographs show almost monolayer dispersion of saponite and montmorillonite and high orientation parallel to the film surface.
34980351	3	4	theme	assisted	512:519	arg1	filtration					556:565	vacuum-assisted filtration	540:565	vacuum-assisted filtration	540:565	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	4	theme	assisted	512:519	arg1	assembly					530:537	capillary force assisted physical assembly	496:537	capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica	496:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	4	5	theme	film	877:880	arg1	surface					882:888	the film surface	873:888	the film surface	873:888	X-ray diffraction and transmission electron micrographs show almost monolayer dispersion of saponite and montmorillonite and high orientation parallel to the film surface.
34980351	2	6	theme	hybrids	283:289	arg1	properties					254:263	properties	254:263	properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets	254:327	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	1	7	from	nature	143:148	arg1	components					127:136	components	127:136	components from nature	127:148	Nanocomposites based on components from nature, which can be recycled are of great interest in new materials for sustainable development.
34980351	2	8	theme	nacre-inspired	268:281	arg1	hybrids					283:289	nacre-inspired hybrids	268:289	nacre-inspired hybrids of 1D cellulose and 2D clay platelets	268:327	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	4	9	theme	transmission	741:752	arg1	micrographs					763:773	transmission electron micrographs	741:773	transmission electron micrographs	741:773	X-ray diffraction and transmission electron micrographs show almost monolayer dispersion of saponite and montmorillonite and high orientation parallel to the film surface.
34980351	0	10	from	silicates	55:63	arg1	matrix					95:100	cellulose nanofibril (CNF) matrix	68:100	cellulose nanofibril (CNF) matrix	68:100	Recyclable nanocomposites of well-dispersed 2D layered silicates in cellulose nanofibril (CNF) matrix.
34980351	3	11	theme	compositions	467:478	arg1	range					458:462	a wide range	451:462	a wide range of compositions	451:478	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	5	12	theme	ultimate	905:912	arg1	strength					914:921	ultimate strength	905:921	ultimate strength up to 573 MPa	905:935	Films exhibit ultimate strength up to 573 MPa.
34980351	2	13	theme	properties	254:263	arg1	range					245:249	The range	241:249	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets	241:327	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	3	14	theme	vacuum-assisted	540:554	arg1	filtration					556:565	vacuum-assisted filtration	540:565	vacuum-assisted filtration	540:565	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	14	theme	vacuum-assisted	540:554	arg1	assembly					530:537	capillary force assisted physical assembly	496:537	capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica	496:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	15	theme	cellulose	586:594	arg1	TOCN					608:611	TOCN	608:611	TOCN	608:611	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	15	theme	cellulose	586:594	arg1	nanofibers					596:605	TEMPO-oxidized cellulose nanofibers	571:605	TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica	571:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	6	16	theme	Young	938:942	arg1	modulus					946:952	Young's modulus	938:952	Young's modulus	938:952	Young's modulus exceeds 38 GPa even at high MTM contents (40-80 vol%).
34980351	2	17	theme	nanoparticle	378:389	arg1	dispersion					391:400	improved nanoparticle dispersion	369:400	improved nanoparticle dispersion in the starting hydrocolloid mixture	369:437	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	0	18	theme	Recyclable	0:9	arg1	nanocomposites					11:24	Recyclable nanocomposites	0:24	Recyclable nanocomposites of well-dispersed 2D	0:45	Recyclable nanocomposites of well-dispersed 2D layered silicates in cellulose nanofibril (CNF) matrix.
34980351	0	18	theme	Recyclable	0:9	arg1	2D					44:45	well-dispersed 2D	29:45	well-dispersed 2D	29:45	Recyclable nanocomposites of well-dispersed 2D layered silicates in cellulose nanofibril (CNF) matrix.
34980351	2	19	theme	cellulose	297:305	arg1	platelets					319:327	1D cellulose and 2D clay platelets	294:327	1D cellulose and 2D clay platelets	294:327	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	2	20	theme	improved	369:376	arg1	dispersion					391:400	improved nanoparticle dispersion	369:400	improved nanoparticle dispersion in the starting hydrocolloid mixture	369:437	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	0	21	theme	well-dispersed	29:42	arg1	2D					44:45	well-dispersed 2D	29:45	well-dispersed 2D	29:45	Recyclable nanocomposites of well-dispersed 2D layered silicates in cellulose nanofibril (CNF) matrix.
34980351	6	22	theme	vol	1002:1004	arg1	contents					986:993	high MTM contents	977:993	high MTM contents (40-80 vol%)	977:1006	Young's modulus exceeds 38 GPa even at high MTM contents (40-80 vol%).
34980351	6	22	theme	vol	1002:1004	arg1	%					1005:1005	40-80 vol%	996:1005	40-80 vol%	996:1005	Young's modulus exceeds 38 GPa even at high MTM contents (40-80 vol%).
34980351	2	23	theme	1D	294:295	arg1	cellulose					297:305	1D cellulose	294:305	1D cellulose	294:305	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	1	24	theme	great	180:184	arg1	interest					186:193	great interest	180:193	great interest	180:193	Nanocomposites based on components from nature, which can be recycled are of great interest in new materials for sustainable development.
34980351	3	25	theme	nanofibers	596:605	arg1	filtration					556:565	vacuum-assisted filtration	540:565	vacuum-assisted filtration	540:565	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	25	theme	nanofibers	596:605	arg1	assembly					530:537	capillary force assisted physical assembly	496:537	capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica	496:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	26	theme	aspect	668:673	arg1	ratios					675:680	three different aspect ratios	652:680	three different aspect ratios	652:680	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	27	theme	TEMPO-oxidized	571:584	arg1	TOCN					608:611	TOCN	608:611	TOCN	608:611	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	27	theme	TEMPO-oxidized	571:584	arg1	nanofibers					596:605	TEMPO-oxidized cellulose nanofibers	571:605	TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica	571:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	2	28	theme	hydrocolloid	418:429	arg1	mixture					431:437	the starting hydrocolloid mixture	405:437	the starting hydrocolloid mixture	405:437	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	7	29	theme	nanoplatelet	1158:1169	arg1	dispersion					1171:1180	the 2D nanoplatelet dispersion	1151:1180	the 2D nanoplatelet dispersion	1151:1180	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties are measured, found to be very good and are sensitive to the 2D nanoplatelet dispersion.
34980351	3	30	theme	capillary	496:504	arg1	filtration					556:565	vacuum-assisted filtration	540:565	vacuum-assisted filtration	540:565	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	30	theme	capillary	496:504	arg1	assembly					530:537	capillary force assisted physical assembly	496:537	capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica	496:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	31	theme	ratios	675:680	arg1	saponite					683:690	saponite	683:690	saponite	683:690	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	31	theme	ratios	675:680	arg1	nanoclays					639:647	exfoliated nanoclays	628:647	exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica	628:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	31	theme	ratios	675:680	arg1	mica					713:716	mica	713:716	mica	713:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	31	theme	ratios	675:680	arg1	montmorillonite					693:707	montmorillonite	693:707	montmorillonite	693:707	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	2	32	theme	starting	409:416	arg1	mixture					431:437	the starting hydrocolloid mixture	405:437	the starting hydrocolloid mixture	405:437	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	0	33	theme	2D	44:45	arg1	nanocomposites					11:24	Recyclable nanocomposites	0:24	Recyclable nanocomposites of well-dispersed 2D	0:45	Recyclable nanocomposites of well-dispersed 2D layered silicates in cellulose nanofibril (CNF) matrix.
34980351	0	33	theme	2D	44:45	arg1	2D					44:45	well-dispersed 2D	29:45	well-dispersed 2D	29:45	Recyclable nanocomposites of well-dispersed 2D layered silicates in cellulose nanofibril (CNF) matrix.
34980351	4	34	theme	parallel	861:868	arg1	orientation					849:859	high orientation	844:859	high orientation parallel to the film surface	844:888	X-ray diffraction and transmission electron micrographs show almost monolayer dispersion of saponite and montmorillonite and high orientation parallel to the film surface.
34980351	1	35	theme	new	198:200	arg1	materials					202:210	new materials	198:210	new materials for sustainable development	198:238	Nanocomposites based on components from nature, which can be recycled are of great interest in new materials for sustainable development.
34980351	6	36	theme	MTM	982:984	arg1	contents					986:993	high MTM contents	977:993	high MTM contents (40-80 vol%)	977:1006	Young's modulus exceeds 38 GPa even at high MTM contents (40-80 vol%).
34980351	6	36	theme	MTM	982:984	arg1	%					1005:1005	40-80 vol%	996:1005	40-80 vol%	996:1005	Young's modulus exceeds 38 GPa even at high MTM contents (40-80 vol%).
34980351	7	37	theme	fire-retardant	1068:1081	arg1	properties					1083:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties	1009:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties	1009:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties are measured, found to be very good and are sensitive to the 2D nanoplatelet dispersion.
34980351	3	38	theme	different	658:666	arg1	ratios					675:680	three different aspect ratios	652:680	three different aspect ratios	652:680	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	39	dep	nanoclays	639:647	arg1	saponite					683:690	saponite	683:690	saponite	683:690	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	39	dep	nanoclays	639:647	arg1	nanoclays					639:647	exfoliated nanoclays	628:647	exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica	628:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	39	dep	nanoclays	639:647	arg1	mica					713:716	mica	713:716	mica	713:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	39	dep	nanoclays	639:647	arg1	montmorillonite					693:707	montmorillonite	693:707	montmorillonite	693:707	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	7	40	theme	2D	1155:1156	arg1	dispersion					1171:1180	the 2D nanoplatelet dispersion	1151:1180	the 2D nanoplatelet dispersion	1151:1180	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties are measured, found to be very good and are sensitive to the 2D nanoplatelet dispersion.
34980351	6	41	theme	high	977:980	arg1	contents					986:993	high MTM contents	977:993	high MTM contents (40-80 vol%)	977:1006	Young's modulus exceeds 38 GPa even at high MTM contents (40-80 vol%).
34980351	6	41	theme	high	977:980	arg1	%					1005:1005	40-80 vol%	996:1005	40-80 vol%	996:1005	Young's modulus exceeds 38 GPa even at high MTM contents (40-80 vol%).
34980351	3	42	with	Films	440:444	arg1	range					458:462	a wide range	451:462	a wide range of compositions	451:478	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	7	43	theme	UV-shielding	1032:1043	arg1	properties					1083:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties	1009:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties	1009:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties are measured, found to be very good and are sensitive to the 2D nanoplatelet dispersion.
34980351	2	44	theme	platelets	319:327	arg1	hybrids					283:289	nacre-inspired hybrids	268:289	nacre-inspired hybrids of 1D cellulose and 2D clay platelets	268:327	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	4	45	theme	high	844:847	arg1	orientation					849:859	high orientation	844:859	high orientation parallel to the film surface	844:888	X-ray diffraction and transmission electron micrographs show almost monolayer dispersion of saponite and montmorillonite and high orientation parallel to the film surface.
34980351	7	46	theme	shielding	1054:1062	arg1	properties					1083:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties	1009:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties	1009:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties are measured, found to be very good and are sensitive to the 2D nanoplatelet dispersion.
34980351	1	47	from	interest	186:193	arg1	materials					202:210	new materials	198:210	new materials for sustainable development	198:238	Nanocomposites based on components from nature, which can be recycled are of great interest in new materials for sustainable development.
34980351	2	48	theme	clay	314:317	arg1	platelets					319:327	1D cellulose and 2D clay platelets	294:327	1D cellulose and 2D clay platelets	294:327	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	4	49	theme	monolayer	787:795	arg1	dispersion					797:806	almost monolayer dispersion	780:806	almost monolayer dispersion of saponite and montmorillonite	780:838	X-ray diffraction and transmission electron micrographs show almost monolayer dispersion of saponite and montmorillonite and high orientation parallel to the film surface.
34980351	2	50	from	dispersion	391:400	arg1	mixture					431:437	the starting hydrocolloid mixture	405:437	the starting hydrocolloid mixture	405:437	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	4	51	theme	montmorillonite	824:838	arg1	orientation					849:859	high orientation	844:859	high orientation parallel to the film surface	844:888	X-ray diffraction and transmission electron micrographs show almost monolayer dispersion of saponite and montmorillonite and high orientation parallel to the film surface.
34980351	4	51	theme	montmorillonite	824:838	arg1	dispersion					797:806	almost monolayer dispersion	780:806	almost monolayer dispersion of saponite and montmorillonite	780:838	X-ray diffraction and transmission electron micrographs show almost monolayer dispersion of saponite and montmorillonite and high orientation parallel to the film surface.
34980351	7	52	theme	Optical	1009:1015	arg1	properties					1083:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties	1009:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties	1009:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties are measured, found to be very good and are sensitive to the 2D nanoplatelet dispersion.
34980351	2	53	theme	2D	311:312	arg1	clay					314:317	2D clay	311:317	2D clay	311:317	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	4	54	theme	electron	754:761	arg1	micrographs					763:773	transmission electron micrographs	741:773	transmission electron micrographs	741:773	X-ray diffraction and transmission electron micrographs show almost monolayer dispersion of saponite and montmorillonite and high orientation parallel to the film surface.
34980351	0	55	theme	nanofibril	78:87	arg1	matrix					95:100	cellulose nanofibril (CNF) matrix	68:100	cellulose nanofibril (CNF) matrix	68:100	Recyclable nanocomposites of well-dispersed 2D layered silicates in cellulose nanofibril (CNF) matrix.
34980351	2	56	with	nanocomposites	349:362	arg1	dispersion					391:400	improved nanoparticle dispersion	369:400	improved nanoparticle dispersion in the starting hydrocolloid mixture	369:437	The range of properties of nacre-inspired hybrids of 1D cellulose and 2D clay platelets are investigated in nanocomposites with improved nanoparticle dispersion in the starting hydrocolloid mixture.
34980351	3	57	theme	wide	453:456	arg1	range					458:462	a wide range	451:462	a wide range of compositions	451:478	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	7	58	theme	transmittance	1017:1029	arg1	properties					1083:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties	1009:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties	1009:1092	Optical transmittance, UV-shielding, thermal shielding and fire-retardant properties are measured, found to be very good and are sensitive to the 2D nanoplatelet dispersion.
34980351	3	59	theme	physical	521:528	arg1	filtration					556:565	vacuum-assisted filtration	540:565	vacuum-assisted filtration	540:565	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	59	theme	physical	521:528	arg1	assembly					530:537	capillary force assisted physical assembly	496:537	capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica	496:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	1	60	theme	sustainable	216:226	arg1	development					228:238	sustainable development	216:238	sustainable development	216:238	Nanocomposites based on components from nature, which can be recycled are of great interest in new materials for sustainable development.
34980351	0	61	theme	cellulose	68:76	arg1	matrix					95:100	cellulose nanofibril (CNF) matrix	68:100	cellulose nanofibril (CNF) matrix	68:100	Recyclable nanocomposites of well-dispersed 2D layered silicates in cellulose nanofibril (CNF) matrix.
34980351	3	62	theme	exfoliated	628:637	arg1	saponite					683:690	saponite	683:690	saponite	683:690	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	62	theme	exfoliated	628:637	arg1	nanoclays					639:647	exfoliated nanoclays	628:647	exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica	628:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	62	theme	exfoliated	628:637	arg1	mica					713:716	mica	713:716	mica	713:716	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
34980351	3	62	theme	exfoliated	628:637	arg1	montmorillonite					693:707	montmorillonite	693:707	montmorillonite	693:707	Films with a wide range of compositions are prepared by capillary force assisted physical assembly (vacuum-assisted filtration) of TEMPO-oxidized cellulose nanofibers (TOCN) reinforced by exfoliated nanoclays of three different aspect ratios: saponite, montmorillonite and mica.
32234446	0	0	theme	surface	85:91	arg1	methodology					93:103	A response surface methodology	74:103	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.	0:129	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.
32234446	2	1	theme	full	502:505	arg1	design					517:522	full factorial design	502:522	full factorial design	502:522	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	4	2	theme	excessive	884:892	arg1	crosslinking					894:905	excessive crosslinking	884:905	excessive crosslinking	884:905	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	2	3	theme	chloride	372:379	arg1	concentration					381:393	calcium chloride concentration	364:393	calcium chloride concentration	364:393	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	2	4	with	composition	582:592	arg1	capacity					618:625	highest adsorption capacity	599:625	highest adsorption capacity	599:625	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	1	5	theme	heavy	260:264	arg1	metals					266:271	heavy metals	260:271	heavy metals	260:271	Different interpenetrating polymeric networks (IPN) based on sodium alginate, carrageenan and bentonite were developed to remove heavy metals and dyes from contaminated water.
32234446	0	6	theme	response	76:83	arg1	methodology					93:103	A response surface methodology	74:103	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.	0:129	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.
32234446	4	7	theme	dyes	832:835	arg1	removal					837:843	dyes removal	832:843	dyes removal	832:843	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	7	8	from	formulations	1246:1257	arg1	waters					1280:1285	real contaminated waters	1262:1285	real contaminated waters from tannery plant and oasis groundwater	1262:1326	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	2	9	theme	calcium	364:370	arg1	concentration					381:393	calcium chloride concentration	364:393	calcium chloride concentration	364:393	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	7	10	from	groundwater	1316:1326	arg1	waters					1280:1285	real contaminated waters	1262:1285	real contaminated waters from tannery plant and oasis groundwater	1262:1326	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	3	11	theme	dye	725:727	arg1	type					702:705	the type	698:705	the type of heavy metal or dye to be removed	698:741	Different optimal conditions and combinations were found depending on the type of heavy metal or dye to be removed.
32234446	7	12	theme	original	1405:1412	arg1	contaminants					1427:1438	the original heavy metals contaminants	1401:1438	the original heavy metals contaminants	1401:1438	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	2	13	theme	surface	537:543	arg1	methodology					545:555	response surface methodology	528:555	response surface methodology	528:555	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	4	14	from	effect	874:879	arg1	percentage					922:931	the removal percentage	910:931	the removal percentage	910:931	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	4	15	theme	crosslinking	894:905	arg1	effect					874:879	the negative effect	861:879	the negative effect of excessive crosslinking on the removal percentage	861:931	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	4	16	from	factor	792:797	arg1	cases					806:810	all cases	802:810	all cases of heavy metals and dyes removal	802:843	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	4	17	theme	calcium	748:754	arg1	factor					792:797	a common factor	783:797	a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage	783:931	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	4	17	theme	calcium	748:754	arg1	concentration					765:777	Low calcium chloride concentration	744:777	Low calcium chloride concentration	744:777	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	6	18	from	drop	1178:1181	arg1	efficiency					1200:1209	their removal efficiency	1186:1209	their removal efficiency	1186:1209	Reusability tests confirmed that the optimized formulations can be reused five successive times without significant drop in their removal efficiency.
32234446	4	19	theme	Low	744:746	arg1	factor					792:797	a common factor	783:797	a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage	783:931	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	4	19	theme	Low	744:746	arg1	concentration					765:777	Low calcium chloride concentration	744:777	Low calcium chloride concentration	744:777	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	2	20	theme	response	528:535	arg1	methodology					545:555	response surface methodology	528:555	response surface methodology	528:555	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	4	21	theme	chloride	756:763	arg1	factor					792:797	a common factor	783:797	a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage	783:931	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	4	21	theme	chloride	756:763	arg1	concentration					765:777	Low calcium chloride concentration	744:777	Low calcium chloride concentration	744:777	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	7	22	theme	metals	1420:1425	arg1	contaminants					1427:1438	the original heavy metals contaminants	1401:1438	the original heavy metals contaminants	1401:1438	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	7	23	theme	contaminants	1427:1438	arg1	%					1396:1396	above 95%	1388:1396	above 95% of the original heavy metals contaminants	1388:1438	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	7	23	theme	contaminants	1427:1438	arg1	content					1466:1472	the acidic dye content	1451:1472	the acidic dye content	1451:1472	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	7	23	theme	contaminants	1427:1438	arg1	contaminants					1427:1438	the original heavy metals contaminants	1401:1438	the original heavy metals contaminants	1401:1438	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	7	23	theme	contaminants	1427:1438	arg1	%					1446:1446	40%	1444:1446	40% of the acidic dye content	1444:1472	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	2	24	theme	mass	420:423	arg1	ratio					425:429	carrageenan mass ratio	408:429	carrageenan mass ratio	408:429	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	0	25	theme	optimization	111:122	arg1	study					124:128	optimization study	111:128	optimization study	111:128	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.
32234446	7	26	from	waters	1280:1285	arg1	utilization					1217:1227	utilization	1217:1227	utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater	1217:1326	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	2	27	theme	mass	460:463	arg1	ratio					465:469	carrageenan mass ratio	448:469	carrageenan mass ratio	448:469	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	2	28	theme	carrageenan	408:418	arg1	ratio					425:429	carrageenan mass ratio	408:429	carrageenan mass ratio	408:429	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	0	29	theme	alginate-based	4:17	arg1	networks					44:51	New alginate-based interpenetrating polymer networks	0:51	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.	0:129	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.
32234446	5	30	theme	methylene	961:969	arg1	adsorbent					1037:1045	adsorbent	1037:1045	adsorbent	1037:1045	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions is 1271, 1550, 1500 and 1540 mg/g adsorbent, respectively.
32234446	5	30	theme	methylene	961:969	arg1	capacity					949:956	The adsorption capacity	934:956	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions	934:1001	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions is 1271, 1550, 1500 and 1540 mg/g adsorbent, respectively.
32234446	7	31	theme	dye	1462:1464	arg1	content					1466:1472	the acidic dye content	1451:1472	the acidic dye content	1451:1472	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	1	32	theme	sodium	192:197	arg1	alginate					199:206	sodium alginate	192:206	sodium alginate	192:206	Different interpenetrating polymeric networks (IPN) based on sodium alginate, carrageenan and bentonite were developed to remove heavy metals and dyes from contaminated water.
32234446	0	33	theme	New	0:2	arg1	networks					44:51	New alginate-based interpenetrating polymer networks	0:51	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.	0:129	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.
32234446	4	34	theme	negative	865:872	arg1	effect					874:879	the negative effect	861:879	the negative effect of excessive crosslinking on the removal percentage	861:931	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	2	35	theme	preparation	324:334	arg1	factors					336:342	Four significant preparation factors	307:342	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.	307:626	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	7	36	from	plant	1300:1304	arg1	waters					1280:1285	real contaminated waters	1262:1285	real contaminated waters from tannery plant and oasis groundwater	1262:1326	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	0	37	theme	polymer	36:42	arg1	networks					44:51	New alginate-based interpenetrating polymer networks	0:51	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.	0:129	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.
32234446	1	38	theme	contaminated	287:298	arg1	water					300:304	contaminated water	287:304	contaminated water	287:304	Different interpenetrating polymeric networks (IPN) based on sodium alginate, carrageenan and bentonite were developed to remove heavy metals and dyes from contaminated water.
32234446	2	39	theme	optimum	574:580	arg1	composition					582:592	the optimum composition	570:592	the optimum composition with highest adsorption capacity	570:625	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	4	40	theme	removal	837:843	arg1	cases					806:810	all cases	802:810	all cases of heavy metals and dyes removal	802:843	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	2	41	theme	significant	312:322	arg1	factors					336:342	Four significant preparation factors	307:342	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.	307:626	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	2	42	dep	factors	336:342	arg1	studied					476:482	studied	476:482	studied	476:482	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	2	42	dep	factors	336:342	arg1	optimized					488:496	optimized	488:496	optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity	488:625	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	0	43	theme	interpenetrating	19:34	arg1	networks					44:51	New alginate-based interpenetrating polymer networks	0:51	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.	0:129	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.
32234446	5	44	theme	blue	971:974	arg1	methylene					961:969	methylene blue	961:974	methylene blue	961:974	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions is 1271, 1550, 1500 and 1540 mg/g adsorbent, respectively.
32234446	5	45	theme	Fe3+	977:980	arg1	adsorbent					1037:1045	adsorbent	1037:1045	adsorbent	1037:1045	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions is 1271, 1550, 1500 and 1540 mg/g adsorbent, respectively.
32234446	5	45	theme	Fe3+	977:980	arg1	capacity					949:956	The adsorption capacity	934:956	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions	934:1001	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions is 1271, 1550, 1500 and 1540 mg/g adsorbent, respectively.
32234446	7	46	theme	heavy	1414:1418	arg1	contaminants					1427:1438	the original heavy metals contaminants	1401:1438	the original heavy metals contaminants	1401:1438	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	7	47	theme	real	1262:1265	arg1	waters					1280:1285	real contaminated waters	1262:1285	real contaminated waters from tannery plant and oasis groundwater	1262:1326	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	5	48	theme	adsorption	938:947	arg1	adsorbent					1037:1045	adsorbent	1037:1045	adsorbent	1037:1045	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions is 1271, 1550, 1500 and 1540 mg/g adsorbent, respectively.
32234446	5	48	theme	adsorption	938:947	arg1	capacity					949:956	The adsorption capacity	934:956	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions	934:1001	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions is 1271, 1550, 1500 and 1540 mg/g adsorbent, respectively.
32234446	3	49	theme	Different	628:636	arg1	conditions					646:655	Different optimal conditions	628:655	Different optimal conditions	628:655	Different optimal conditions and combinations were found depending on the type of heavy metal or dye to be removed.
32234446	7	50	theme	content	1466:1472	arg1	%					1396:1396	above 95%	1388:1396	above 95% of the original heavy metals contaminants	1388:1438	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	7	50	theme	content	1466:1472	arg1	content					1466:1472	the acidic dye content	1451:1472	the acidic dye content	1451:1472	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	7	50	theme	content	1466:1472	arg1	contaminants					1427:1438	the original heavy metals contaminants	1401:1438	the original heavy metals contaminants	1401:1438	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	7	50	theme	content	1466:1472	arg1	%					1446:1446	40%	1444:1446	40% of the acidic dye content	1444:1472	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	4	51	theme	common	785:790	arg1	factor					792:797	a common factor	783:797	a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage	783:931	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	4	51	theme	common	785:790	arg1	concentration					765:777	Low calcium chloride concentration	744:777	Low calcium chloride concentration	744:777	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	2	52	theme	carrageenan	448:458	arg1	ratio					465:469	carrageenan mass ratio	448:469	carrageenan mass ratio	448:469	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	7	53	theme	oasis	1310:1314	arg1	groundwater					1316:1326	oasis groundwater	1310:1326	oasis groundwater	1310:1326	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	2	54	theme	adsorption	607:616	arg1	capacity					618:625	highest adsorption capacity	599:625	highest adsorption capacity	599:625	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	7	55	theme	optimized	1236:1244	arg1	formulations					1246:1257	the optimized formulations	1232:1257	the optimized formulations on real contaminated waters from tannery plant and oasis groundwater	1232:1326	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	5	56	theme	Ni2+	983:986	arg1	adsorbent					1037:1045	adsorbent	1037:1045	adsorbent	1037:1045	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions is 1271, 1550, 1500 and 1540 mg/g adsorbent, respectively.
32234446	5	56	theme	Ni2+	983:986	arg1	capacity					949:956	The adsorption capacity	934:956	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions	934:1001	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions is 1271, 1550, 1500 and 1540 mg/g adsorbent, respectively.
32234446	7	57	theme	tannery	1292:1298	arg1	plant					1300:1304	tannery plant	1292:1304	tannery plant	1292:1304	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	0	58	theme	water	57:61	arg1	treatment					63:71	water treatment	57:71	water treatment	57:71	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.
32234446	4	59	theme	removal	914:920	arg1	percentage					922:931	the removal percentage	910:931	the removal percentage	910:931	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	2	60	theme	highest	599:605	arg1	capacity					618:625	highest adsorption capacity	599:625	highest adsorption capacity	599:625	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	7	61	from	utilization	1217:1227	arg1	waters					1280:1285	real contaminated waters	1262:1285	real contaminated waters from tannery plant and oasis groundwater	1262:1326	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	0	62	dep	networks	44:51	arg1	methodology					93:103	A response surface methodology	74:103	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.	0:129	New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.
32234446	7	63	theme	excellent	1350:1358	arg1	performance					1360:1370	an excellent performance	1347:1370	an excellent performance	1347:1370	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	1	64	theme	Different	131:139	arg1	IPN					178:180	IPN	178:180	IPN	178:180	Different interpenetrating polymeric networks (IPN) based on sodium alginate, carrageenan and bentonite were developed to remove heavy metals and dyes from contaminated water.
32234446	1	64	theme	Different	131:139	arg1	networks					168:175	Different interpenetrating polymeric networks	131:175	Different interpenetrating polymeric networks (IPN) based on sodium alginate, carrageenan and bentonite	131:233	Different interpenetrating polymeric networks (IPN) based on sodium alginate, carrageenan and bentonite were developed to remove heavy metals and dyes from contaminated water.
32234446	6	65	theme	removal	1192:1198	arg1	efficiency					1200:1209	their removal efficiency	1186:1209	their removal efficiency	1186:1209	Reusability tests confirmed that the optimized formulations can be reused five successive times without significant drop in their removal efficiency.
32234446	3	66	theme	metal	716:720	arg1	type					702:705	the type	698:705	the type of heavy metal or dye to be removed	698:741	Different optimal conditions and combinations were found depending on the type of heavy metal or dye to be removed.
32234446	5	67	theme	Cr3+	993:996	arg1	ions					998:1001	Cr3+ ions	993:1001	Cr3+ ions	993:1001	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions is 1271, 1550, 1500 and 1540 mg/g adsorbent, respectively.
32234446	3	68	theme	optimal	638:644	arg1	conditions					646:655	Different optimal conditions	628:655	Different optimal conditions	628:655	Different optimal conditions and combinations were found depending on the type of heavy metal or dye to be removed.
32234446	1	69	theme	interpenetrating	141:156	arg1	IPN					178:180	IPN	178:180	IPN	178:180	Different interpenetrating polymeric networks (IPN) based on sodium alginate, carrageenan and bentonite were developed to remove heavy metals and dyes from contaminated water.
32234446	1	69	theme	interpenetrating	141:156	arg1	networks					168:175	Different interpenetrating polymeric networks	131:175	Different interpenetrating polymeric networks (IPN) based on sodium alginate, carrageenan and bentonite	131:233	Different interpenetrating polymeric networks (IPN) based on sodium alginate, carrageenan and bentonite were developed to remove heavy metals and dyes from contaminated water.
32234446	6	70	theme	successive	1141:1150	arg1	times					1152:1156	five successive times	1136:1156	five successive times	1136:1156	Reusability tests confirmed that the optimized formulations can be reused five successive times without significant drop in their removal efficiency.
32234446	6	71	theme	significant	1166:1176	arg1	drop					1178:1181	significant drop	1166:1181	significant drop in their removal efficiency	1166:1209	Reusability tests confirmed that the optimized formulations can be reused five successive times without significant drop in their removal efficiency.
32234446	5	72	theme	ions	998:1001	arg1	adsorbent					1037:1045	adsorbent	1037:1045	adsorbent	1037:1045	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions is 1271, 1550, 1500 and 1540 mg/g adsorbent, respectively.
32234446	5	72	theme	ions	998:1001	arg1	capacity					949:956	The adsorption capacity	934:956	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions	934:1001	The adsorption capacity of methylene blue, Fe3+, Ni2+, and Cr3+ ions is 1271, 1550, 1500 and 1540 mg/g adsorbent, respectively.
32234446	1	73	theme	polymeric	158:166	arg1	IPN					178:180	IPN	178:180	IPN	178:180	Different interpenetrating polymeric networks (IPN) based on sodium alginate, carrageenan and bentonite were developed to remove heavy metals and dyes from contaminated water.
32234446	1	73	theme	polymeric	158:166	arg1	networks					168:175	Different interpenetrating polymeric networks	131:175	Different interpenetrating polymeric networks (IPN) based on sodium alginate, carrageenan and bentonite	131:233	Different interpenetrating polymeric networks (IPN) based on sodium alginate, carrageenan and bentonite were developed to remove heavy metals and dyes from contaminated water.
32234446	2	74	theme	crosslinking	345:356	arg1	time					358:361	crosslinking time	345:361	crosslinking time	345:361	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	7	75	theme	acidic	1455:1460	arg1	content					1466:1472	the acidic dye content	1451:1472	the acidic dye content	1451:1472	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	4	76	theme	metals	821:826	arg1	cases					806:810	all cases	802:810	all cases of heavy metals and dyes removal	802:843	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	6	77	theme	optimized	1099:1107	arg1	formulations					1109:1120	the optimized formulations	1095:1120	the optimized formulations	1095:1120	Reusability tests confirmed that the optimized formulations can be reused five successive times without significant drop in their removal efficiency.
32234446	6	78	theme	Reusability	1062:1072	arg1	tests					1074:1078	Reusability tests	1062:1078	Reusability tests	1062:1078	Reusability tests confirmed that the optimized formulations can be reused five successive times without significant drop in their removal efficiency.
32234446	2	79	theme	factorial	507:515	arg1	design					517:522	full factorial design	502:522	full factorial design	502:522	Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity.
32234446	4	80	theme	heavy	815:819	arg1	metals					821:826	heavy metals	815:826	heavy metals	815:826	Low calcium chloride concentration was a common factor in all cases of heavy metals and dyes removal which indicates the negative effect of excessive crosslinking on the removal percentage.
32234446	7	81	theme	contaminated	1267:1278	arg1	waters					1280:1285	real contaminated waters	1262:1285	real contaminated waters from tannery plant and oasis groundwater	1262:1326	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
32234446	7	82	theme	formulations	1246:1257	arg1	utilization					1217:1227	utilization	1217:1227	utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater	1217:1326	Upon utilization of the optimized formulations on real contaminated waters from tannery plant and oasis groundwater, they demonstrated an excellent performance as they removed above 95% of the original heavy metals contaminants and 40% of the acidic dye content.
34202759	0	0	theme	Scaffolds	125:133	arg1	Biomineralization					44:60	Biomineralization	44:60	Biomineralization	44:60	Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration.
34202759	0	0	theme	Scaffolds	125:133	arg1	Effect					0:5	Effect	0:5	Effect of Morphological Characteristics	0:38	Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration.
34202759	2	1	theme	/hydroxyapatite	510:524	arg1	printing					470:477	a simple 3D printing	458:477	a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration	458:601	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	3	2	theme	homogeneous	660:670	arg1	distribution					677:688	homogeneous pore distribution	660:688	homogeneous pore distribution	660:688	The resulting scaffolds exhibited uniform structure and homogeneous pore distribution.
34202759	5	3	theme	cell	996:999	arg1	proliferation					1001:1013	cell proliferation	996:1013	cell proliferation	996:1013	The results of bioactivity assays proved that the morphological characteristics and biomineralization of the composite scaffolds influenced cell proliferation and osteogenic differentiation.
34202759	0	4	theme	Composite	115:123	arg1	Scaffolds					125:133	3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds	65:133	3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds	65:133	Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration.
34202759	4	5	with	structure	773:781	arg1	surface					808:814	a wrinkled internal surface	788:814	a wrinkled internal surface	788:814	In addition, the microstructures of the composite scaffolds showed an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture.
34202759	4	5	with	structure	773:781	arg1	architecture					842:853	a porous hierarchical architecture	820:853	a porous hierarchical architecture	820:853	In addition, the microstructures of the composite scaffolds showed an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture.
34202759	6	6	theme	staggered	1134:1142	arg1	GEHA20-ZZS					1156:1165	GEHA20-ZZS	1156:1165	GEHA20-ZZS	1156:1165	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	6	6	theme	staggered	1134:1142	arg1	orthogonal					1144:1153	double-layer staggered orthogonal	1121:1153	double-layer staggered orthogonal (GEHA20-ZZS)	1121:1166	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	0	7	theme	Bone	138:141	arg1	Regeneration					150:161	Bone Tissue Regeneration	138:161	Bone Tissue Regeneration	138:161	Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration.
34202759	0	8	from	Effect	0:5	arg1	Regeneration					150:161	Bone Tissue Regeneration	138:161	Bone Tissue Regeneration	138:161	Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration.
34202759	8	9	from	scaffolds	1443:1451	arg1	regeneration					1461:1472	bone regeneration	1456:1472	bone regeneration	1456:1472	Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.
34202759	4	10	theme	porous	822:827	arg1	architecture					842:853	a porous hierarchical architecture	820:853	a porous hierarchical architecture	820:853	In addition, the microstructures of the composite scaffolds showed an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture.
34202759	6	11	theme	double-layer	1121:1132	arg1	GEHA20-ZZS					1156:1165	GEHA20-ZZS	1156:1165	GEHA20-ZZS	1156:1165	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	6	11	theme	double-layer	1121:1132	arg1	orthogonal					1144:1153	double-layer staggered orthogonal	1121:1153	double-layer staggered orthogonal (GEHA20-ZZS)	1121:1166	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	2	12	theme	subsequent	536:545	arg1	biomineralization					547:563	subsequent biomineralization	536:563	subsequent biomineralization for improved bone tissue regeneration	536:601	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	1	13	theme	bone	389:392	arg1	ECM					381:383	ECM	381:383	ECM	381:383	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	1	13	theme	bone	389:392	arg1	matrix					373:378	the natural extracellular matrix	347:378	the natural extracellular matrix (ECM) of bone	347:392	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	7	14	contain	has	1314:1316	arg1	biomineralization					1296:1312	biomineralization	1296:1312	biomineralization	1296:1312	According to these results, biomineralization has a great influence on the biological activity of cells.
34202759	7	14	contain	has	1314:1316	arg2	influence					1326:1334	a great influence	1318:1334	a great influence on the biological activity of cells	1318:1370	According to these results, biomineralization has a great influence on the biological activity of cells.
34202759	8	15	used	used	1426:1429	arg2	scaffolds					1409:1417	the biomineralized composite scaffolds	1380:1417	the biomineralized composite scaffolds	1380:1417	Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.
34202759	8	15	used	used	1426:1429	arg2	scaffolds					1443:1451	new bone scaffolds	1434:1451	new bone scaffolds in bone regeneration	1434:1472	Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.
34202759	4	16	theme	wrinkled	790:797	arg1	surface					808:814	a wrinkled internal surface	788:814	a wrinkled internal surface	788:814	In addition, the microstructures of the composite scaffolds showed an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture.
34202759	7	17	theme	great	1320:1324	arg1	influence					1326:1334	a great influence	1318:1334	a great influence on the biological activity of cells	1318:1370	According to these results, biomineralization has a great influence on the biological activity of cells.
34202759	5	18	theme	morphological	906:918	arg1	characteristics					920:934	the morphological characteristics	902:934	the morphological characteristics	902:934	The results of bioactivity assays proved that the morphological characteristics and biomineralization of the composite scaffolds influenced cell proliferation and osteogenic differentiation.
34202759	6	19	with	scaffolds	1106:1114	arg1	structure					1197:1205	double-layer alternative structure	1172:1205	double-layer alternative structure (GEHA20-45S)	1172:1218	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	6	19	with	scaffolds	1106:1114	arg1	GEHA20-ZZS					1156:1165	GEHA20-ZZS	1156:1165	GEHA20-ZZS	1156:1165	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	6	19	with	scaffolds	1106:1114	arg1	orthogonal					1144:1153	double-layer staggered orthogonal	1121:1153	double-layer staggered orthogonal (GEHA20-ZZS)	1121:1166	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	6	19	with	scaffolds	1106:1114	arg1	GEHA20-45S					1208:1217	GEHA20-45S	1208:1217	GEHA20-45S	1208:1217	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	2	20	theme	biomimetic	423:432	arg1	scaffolds					444:452	biomimetic composite scaffolds	423:452	biomimetic composite scaffolds	423:452	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	0	21	theme	Tissue	143:148	arg1	Regeneration					150:161	Bone Tissue Regeneration	138:161	Bone Tissue Regeneration	138:161	Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration.
34202759	0	22	from	Biomineralization	44:60	arg1	Regeneration					150:161	Bone Tissue Regeneration	138:161	Bone Tissue Regeneration	138:161	Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration.
34202759	4	23	theme	hierarchical	829:840	arg1	architecture					842:853	a porous hierarchical architecture	820:853	a porous hierarchical architecture	820:853	In addition, the microstructures of the composite scaffolds showed an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture.
34202759	1	24	theme	composite	205:213	arg1	scaffolds					215:223	porous three-dimensional (3D) composite scaffolds	175:223	porous three-dimensional (3D) composite scaffolds	175:223	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	5	25	theme	bioactivity	871:881	arg1	assays					883:888	bioactivity assays	871:888	bioactivity assays	871:888	The results of bioactivity assays proved that the morphological characteristics and biomineralization of the composite scaffolds influenced cell proliferation and osteogenic differentiation.
34202759	6	26	theme	biomineralized	1066:1079	arg1	scaffolds					1106:1114	the biomineralized gelatin/HA/HAp composite scaffolds	1062:1114	the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S)	1062:1218	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	6	27	theme	higher	1227:1232	arg1	bioactivity					1234:1244	higher bioactivity	1227:1244	higher bioactivity	1227:1244	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	4	28	theme	internal	799:806	arg1	surface					808:814	a wrinkled internal surface	788:814	a wrinkled internal surface	788:814	In addition, the microstructures of the composite scaffolds showed an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture.
34202759	1	29	theme	scaffolds	215:223	arg1	use					168:170	The use	164:170	The use of porous three-dimensional (3D) composite scaffolds	164:223	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	5	30	theme	assays	883:888	arg1	results					860:866	The results	856:866	The results of bioactivity assays	856:888	The results of bioactivity assays proved that the morphological characteristics and biomineralization of the composite scaffolds influenced cell proliferation and osteogenic differentiation.
34202759	8	31	theme	biomineralized	1384:1397	arg1	scaffolds					1443:1451	new bone scaffolds	1434:1451	new bone scaffolds in bone regeneration	1434:1472	Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.
34202759	8	31	theme	biomineralized	1384:1397	arg1	scaffolds					1409:1417	the biomineralized composite scaffolds	1380:1417	the biomineralized composite scaffolds	1380:1417	Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.
34202759	3	32	theme	resulting	608:616	arg1	scaffolds					618:626	The resulting scaffolds	604:626	The resulting scaffolds	604:626	The resulting scaffolds exhibited uniform structure and homogeneous pore distribution.
34202759	5	33	theme	composite	965:973	arg1	scaffolds					975:983	the composite scaffolds	961:983	the composite scaffolds	961:983	The results of bioactivity assays proved that the morphological characteristics and biomineralization of the composite scaffolds influenced cell proliferation and osteogenic differentiation.
34202759	0	34	theme	Characteristics	24:38	arg1	Biomineralization					44:60	Biomineralization	44:60	Biomineralization	44:60	Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration.
34202759	0	34	theme	Characteristics	24:38	arg1	Effect					0:5	Effect	0:5	Effect of Morphological Characteristics	0:38	Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration.
34202759	1	35	theme	major	329:333	arg1	features					335:342	the major features	325:342	the major features of the natural extracellular matrix (ECM) of bone	325:392	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	2	36	theme	tissue	583:588	arg1	regeneration					590:601	improved bone tissue regeneration	569:601	improved bone tissue regeneration	569:601	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	2	37	theme	biomineralization	547:563	arg1	printing					470:477	a simple 3D printing	458:477	a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration	458:601	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	0	38	theme	Morphological	10:22	arg1	Characteristics					24:38	Morphological Characteristics	10:38	Morphological Characteristics	10:38	Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration.
34202759	6	39	theme	gelatin/HA/HAp	1081:1094	arg1	scaffolds					1106:1114	the biomineralized gelatin/HA/HAp composite scaffolds	1062:1114	the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S)	1062:1218	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	2	40	theme	bone	578:581	arg1	regeneration					590:601	improved bone tissue regeneration	569:601	improved bone tissue regeneration	569:601	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	1	41	dep	three-dimensional	182:198	arg1	3D					201:202	3D	201:202	3D	201:202	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	2	42	theme	acid	501:504	arg1	HAp					527:529	HAp	527:529	HAp	527:529	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	2	42	theme	acid	501:504	arg1	/hydroxyapatite					510:524	gelatin/hyaluronic acid (HA)/hydroxyapatite	482:524	gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp)	482:530	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	1	43	theme	great	239:243	arg1	attention					245:253	great attention	239:253	great attention in bone tissue engineering applications	239:293	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	5	44	theme	osteogenic	1019:1028	arg1	differentiation					1030:1044	osteogenic differentiation	1019:1044	osteogenic differentiation	1019:1044	The results of bioactivity assays proved that the morphological characteristics and biomineralization of the composite scaffolds influenced cell proliferation and osteogenic differentiation.
34202759	2	45	theme	improved	569:576	arg1	regeneration					590:601	improved bone tissue regeneration	569:601	improved bone tissue regeneration	569:601	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	3	46	theme	uniform	638:644	arg1	structure					646:654	uniform structure	638:654	uniform structure	638:654	The resulting scaffolds exhibited uniform structure and homogeneous pore distribution.
34202759	8	47	theme	composite	1399:1407	arg1	scaffolds					1443:1451	new bone scaffolds	1434:1451	new bone scaffolds in bone regeneration	1434:1472	Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.
34202759	8	47	theme	composite	1399:1407	arg1	scaffolds					1409:1417	the biomineralized composite scaffolds	1380:1417	the biomineralized composite scaffolds	1380:1417	Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.
34202759	6	48	theme	alternative	1185:1195	arg1	structure					1197:1205	double-layer alternative structure	1172:1205	double-layer alternative structure (GEHA20-45S)	1172:1218	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	6	48	theme	alternative	1185:1195	arg1	GEHA20-45S					1208:1217	GEHA20-45S	1208:1217	GEHA20-45S	1208:1217	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	4	49	theme	scaffolds	741:749	arg1	microstructures					708:722	the microstructures	704:722	the microstructures of the composite scaffolds	704:749	In addition, the microstructures of the composite scaffolds showed an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture.
34202759	8	50	theme	bone	1456:1459	arg1	regeneration					1461:1472	bone regeneration	1456:1472	bone regeneration	1456:1472	Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.
34202759	2	51	theme	3D	467:468	arg1	printing					470:477	a simple 3D printing	458:477	a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration	458:601	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	1	52	from	attention	245:253	arg1	applications					282:293	bone tissue engineering applications	258:293	bone tissue engineering applications	258:293	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	2	53	theme	composite	434:442	arg1	scaffolds					444:452	biomimetic composite scaffolds	423:452	biomimetic composite scaffolds	423:452	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	0	54	theme	3D-Printed	65:74	arg1	Scaffolds					125:133	3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds	65:133	3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds	65:133	Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration.
34202759	1	55	theme	natural	351:357	arg1	ECM					381:383	ECM	381:383	ECM	381:383	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	1	55	theme	natural	351:357	arg1	matrix					373:378	the natural extracellular matrix	347:378	the natural extracellular matrix (ECM) of bone	347:392	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	6	56	theme	double-layer	1172:1183	arg1	structure					1197:1205	double-layer alternative structure	1172:1205	double-layer alternative structure (GEHA20-45S)	1172:1218	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	6	56	theme	double-layer	1172:1183	arg1	GEHA20-45S					1208:1217	GEHA20-45S	1208:1217	GEHA20-45S	1208:1217	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	6	57	theme	composite	1096:1104	arg1	scaffolds					1106:1114	the biomineralized gelatin/HA/HAp composite scaffolds	1062:1114	the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S)	1062:1218	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	7	58	from	influence	1326:1334	arg1	activity					1354:1361	the biological activity	1339:1361	the biological activity of cells	1339:1370	According to these results, biomineralization has a great influence on the biological activity of cells.
34202759	8	59	theme	bone	1438:1441	arg1	scaffolds					1443:1451	new bone scaffolds	1434:1451	new bone scaffolds in bone regeneration	1434:1472	Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.
34202759	8	59	theme	bone	1438:1441	arg1	scaffolds					1409:1417	the biomineralized composite scaffolds	1380:1417	the biomineralized composite scaffolds	1380:1417	Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.
34202759	2	60	theme	gelatin/hyaluronic	482:499	arg1	acid					501:504	gelatin/hyaluronic acid	482:504	gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp)	482:530	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	2	60	theme	gelatin/hyaluronic	482:499	arg1	HA					507:508	HA	507:508	HA	507:508	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	1	61	theme	extracellular	359:371	arg1	ECM					381:383	ECM	381:383	ECM	381:383	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	1	61	theme	extracellular	359:371	arg1	matrix					373:378	the natural extracellular matrix	347:378	the natural extracellular matrix (ECM) of bone	347:392	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	7	62	theme	biological	1343:1352	arg1	activity					1354:1361	the biological activity	1339:1361	the biological activity of cells	1339:1370	According to these results, biomineralization has a great influence on the biological activity of cells.
34202759	4	63	theme	ECM-mimetic	761:771	arg1	structure					773:781	an ECM-mimetic structure	758:781	an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture	758:853	In addition, the microstructures of the composite scaffolds showed an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture.
34202759	1	64	theme	matrix	373:378	arg1	features					335:342	the major features	325:342	the major features of the natural extracellular matrix (ECM) of bone	325:392	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	3	65	theme	pore	672:675	arg1	distribution					677:688	homogeneous pore distribution	660:688	homogeneous pore distribution	660:688	The resulting scaffolds exhibited uniform structure and homogeneous pore distribution.
34202759	1	66	theme	bone	258:261	arg1	applications					282:293	bone tissue engineering applications	258:293	bone tissue engineering applications	258:293	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	7	67	theme	cells	1366:1370	arg1	activity					1354:1361	the biological activity	1339:1361	the biological activity of cells	1339:1370	According to these results, biomineralization has a great influence on the biological activity of cells.
34202759	4	68	theme	composite	731:739	arg1	scaffolds					741:749	the composite scaffolds	727:749	the composite scaffolds	727:749	In addition, the microstructures of the composite scaffolds showed an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture.
34202759	1	69	theme	tissue	263:268	arg1	applications					282:293	bone tissue engineering applications	258:293	bone tissue engineering applications	258:293	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	0	70	theme	Acid/Hydroxyapatite	95:113	arg1	Scaffolds					125:133	3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds	65:133	3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds	65:133	Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration.
34202759	6	71	theme	other	1251:1255	arg1	scaffolds					1257:1265	other scaffolds	1251:1265	other scaffolds	1251:1265	In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds.
34202759	1	72	theme	porous	175:180	arg1	scaffolds					215:223	porous three-dimensional (3D) composite scaffolds	175:223	porous three-dimensional (3D) composite scaffolds	175:223	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	1	73	theme	engineering	270:280	arg1	applications					282:293	bone tissue engineering applications	258:293	bone tissue engineering applications	258:293	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	0	74	theme	Gelatin/Hyaluronic	76:93	arg1	Scaffolds					125:133	3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds	65:133	3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds	65:133	Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration.
34202759	5	75	theme	scaffolds	975:983	arg1	characteristics					920:934	the morphological characteristics	902:934	the morphological characteristics	902:934	The results of bioactivity assays proved that the morphological characteristics and biomineralization of the composite scaffolds influenced cell proliferation and osteogenic differentiation.
34202759	5	75	theme	scaffolds	975:983	arg1	biomineralization					940:956	biomineralization	940:956	biomineralization	940:956	The results of bioactivity assays proved that the morphological characteristics and biomineralization of the composite scaffolds influenced cell proliferation and osteogenic differentiation.
34202759	2	76	theme	simple	460:465	arg1	printing					470:477	a simple 3D printing	458:477	a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration	458:601	This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration.
34202759	1	77	theme	three-dimensional	182:198	arg1	scaffolds					215:223	porous three-dimensional (3D) composite scaffolds	175:223	porous three-dimensional (3D) composite scaffolds	175:223	The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone.
34202759	8	78	theme	new	1434:1436	arg1	scaffolds					1443:1451	new bone scaffolds	1434:1451	new bone scaffolds in bone regeneration	1434:1472	Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.
34202759	8	78	theme	new	1434:1436	arg1	scaffolds					1409:1417	the biomineralized composite scaffolds	1380:1417	the biomineralized composite scaffolds	1380:1417	Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.
33600890	0	0	theme	immobilization	70:83	arg1	interference					30:41	the interference	26:41	the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads	26:119	Effect of amine length in the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads.
33600890	4	1	theme	hindrances	1027:1036	arg1	generation					1006:1015	the generation	1002:1015	the generation of steric hindrances	1002:1036	This way, it seems that the most important effect of the presence of aminated compounds came from the generation of steric hindrances to the enzyme/support multi-reaction promoted by the ammines that are interacting with the aldehyde groups.
33600890	3	2	theme	10 mM	802:806	arg1	amine					814:818	10 mM octyl amine	802:818	10 mM octyl amine	802:818	However, it is clear that this effect is higher using octyl amine for all enzymes (in some cases the enzyme immobilized in the presence of 10 mM octyl amine was almost inactivated while the reference kept over 50 % of the initial activity).
33600890	0	3	theme	covalent	61:68	arg1	immobilization					70:83	the multipoint covalent immobilization	46:83	the multipoint covalent immobilization of enzymes on glyoxyl agarose beads	46:119	Effect of amine length in the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads.
33600890	2	4	theme	enzyme-support	580:593	arg1	attachment					615:624	the enzyme-support multipoint covalent attachment	576:624	the enzyme-support multipoint covalent attachment	576:624	As expected, the presence of amines reduced the intensity of the enzyme-support multipoint covalent attachment, and therefore the enzyme stability.
33600890	1	5	theme	penicillin	145:154	arg1	acylase					158:164	penicillin G acylase	145:164	penicillin G acylase	145:164	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	0	6	theme	enzymes	88:94	arg1	immobilization					70:83	the multipoint covalent immobilization	46:83	the multipoint covalent immobilization of enzymes on glyoxyl agarose beads	46:119	Effect of amine length in the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads.
33600890	1	7	theme	ethyl	337:341	arg1	compounds					270:278	different aliphatic compounds	250:278	different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM)	250:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	7	theme	ethyl	337:341	arg1	amine					343:347	ethyl amine	337:347	ethyl amine	337:347	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	3	8	theme	initial	885:891	arg1	activity					893:900	the initial activity	881:900	the initial activity	881:900	However, it is clear that this effect is higher using octyl amine for all enzymes (in some cases the enzyme immobilized in the presence of 10 mM octyl amine was almost inactivated while the reference kept over 50 % of the initial activity).
33600890	5	9	theme	aminated	1178:1185	arg1	compounds					1187:1195	aminated compounds	1178:1195	aminated compounds	1178:1195	In some instances, just 1 mM of aminated compounds is enough to greatly decrease enzyme stability.
33600890	3	10	theme	octyl	808:812	arg1	amine					814:818	10 mM octyl amine	802:818	10 mM octyl amine	802:818	However, it is clear that this effect is higher using octyl amine for all enzymes (in some cases the enzyme immobilized in the presence of 10 mM octyl amine was almost inactivated while the reference kept over 50 % of the initial activity).
33600890	1	11	theme	different	250:258	arg1	amine					369:373	hexyl amine	363:373	hexyl amine (at concentrations ranging from 0 to 20 mM)	363:417	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	11	theme	different	250:258	arg1	amine					429:433	octyl amine	423:433	octyl amine (from 0 to 10 mM)	423:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	11	theme	different	250:258	arg1	compounds					270:278	different aliphatic compounds	250:278	different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM)	250:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	11	theme	different	250:258	arg1	amine					343:347	ethyl amine	337:347	ethyl amine	337:347	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	11	theme	different	250:258	arg1	amine					356:360	butyl amine	350:360	butyl amine	350:360	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	0	12	theme	glyoxyl	99:105	arg1	beads					115:119	glyoxyl agarose beads	99:119	glyoxyl agarose beads	99:119	Effect of amine length in the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads.
33600890	0	13	from	interference	30:41	arg1	beads					115:119	glyoxyl agarose beads	99:119	glyoxyl agarose beads	99:119	Effect of amine length in the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads.
33600890	3	14	theme	activity	893:900	arg1	%					876:876	50 %	873:876	50 % of the initial activity	873:900	However, it is clear that this effect is higher using octyl amine for all enzymes (in some cases the enzyme immobilized in the presence of 10 mM octyl amine was almost inactivated while the reference kept over 50 % of the initial activity).
33600890	3	14	theme	activity	893:900	arg1	activity					893:900	the initial activity	881:900	the initial activity	881:900	However, it is clear that this effect is higher using octyl amine for all enzymes (in some cases the enzyme immobilized in the presence of 10 mM octyl amine was almost inactivated while the reference kept over 50 % of the initial activity).
33600890	3	15	theme	higher	704:709	arg1	amine					723:727	higher using octyl amine	704:727	higher using octyl amine for all enzymes	704:743	However, it is clear that this effect is higher using octyl amine for all enzymes (in some cases the enzyme immobilized in the presence of 10 mM octyl amine was almost inactivated while the reference kept over 50 % of the initial activity).
33600890	1	16	dep	10 mM	446:450	arg1	to					443:444	to	443:444	to	443:444	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	17	theme	G	156:156	arg1	acylase					158:164	penicillin G acylase	145:164	penicillin G acylase	145:164	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	18	theme	butyl	350:354	arg1	compounds					270:278	different aliphatic compounds	250:278	different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM)	250:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	18	theme	butyl	350:354	arg1	amine					356:360	butyl amine	350:360	butyl amine	350:360	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	6	19	theme	extract	1306:1312	arg1	composition					1280:1290	the composition	1276:1290	the composition of the enzyme extract	1276:1312	The results suggested that, if the composition of the enzyme extract is unknown, to eliminate small aminated compounds may be necessary to maximize the enzyme-support reaction.
33600890	6	19	theme	extract	1306:1312	arg1	unknown					1317:1323	unknown	1317:1323	unknown	1317:1323	The results suggested that, if the composition of the enzyme extract is unknown, to eliminate small aminated compounds may be necessary to maximize the enzyme-support reaction.
33600890	1	20	from	concentrations	379:392	arg1	amine					369:373	hexyl amine	363:373	hexyl amine (at concentrations ranging from 0 to 20 mM)	363:417	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	20	from	concentrations	379:392	arg1	amine					429:433	octyl amine	423:433	octyl amine (from 0 to 10 mM)	423:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	20	from	concentrations	379:392	arg1	compounds					270:278	different aliphatic compounds	250:278	different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM)	250:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	20	from	concentrations	379:392	arg1	amine					343:347	ethyl amine	337:347	ethyl amine	337:347	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	20	from	concentrations	379:392	arg1	amine					356:360	butyl amine	350:360	butyl amine	350:360	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	2	21	theme	amines	544:549	arg1	presence					532:539	the presence	528:539	the presence of amines	528:549	As expected, the presence of amines reduced the intensity of the enzyme-support multipoint covalent attachment, and therefore the enzyme stability.
33600890	1	22	theme	octyl	423:427	arg1	amine					429:433	octyl amine	423:433	octyl amine (from 0 to 10 mM)	423:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	22	theme	octyl	423:427	arg1	compounds					270:278	different aliphatic compounds	250:278	different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM)	250:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	23	theme	immobilized	485:495	arg1	stability					504:512	the immobilized enzyme stability	481:512	the immobilized enzyme stability	481:512	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	6	24	theme	enzyme	1299:1304	arg1	extract					1306:1312	the enzyme extract	1295:1312	the enzyme extract	1295:1312	The results suggested that, if the composition of the enzyme extract is unknown, to eliminate small aminated compounds may be necessary to maximize the enzyme-support reaction.
33600890	1	25	theme	aliphatic	260:268	arg1	amine					369:373	hexyl amine	363:373	hexyl amine (at concentrations ranging from 0 to 20 mM)	363:417	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	25	theme	aliphatic	260:268	arg1	amine					429:433	octyl amine	423:433	octyl amine (from 0 to 10 mM)	423:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	25	theme	aliphatic	260:268	arg1	compounds					270:278	different aliphatic compounds	250:278	different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM)	250:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	25	theme	aliphatic	260:268	arg1	amine					343:347	ethyl amine	337:347	ethyl amine	337:347	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	25	theme	aliphatic	260:268	arg1	amine					356:360	butyl amine	350:360	butyl amine	350:360	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	2	26	theme	covalent	606:613	arg1	attachment					615:624	the enzyme-support multipoint covalent attachment	576:624	the enzyme-support multipoint covalent attachment	576:624	As expected, the presence of amines reduced the intensity of the enzyme-support multipoint covalent attachment, and therefore the enzyme stability.
33600890	1	27	theme	enzyme	497:502	arg1	stability					504:512	the immobilized enzyme stability	481:512	the immobilized enzyme stability	481:512	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	28	theme	ficin	170:174	arg1	extract					176:182	ficin extract	170:182	ficin extract	170:182	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	0	29	theme	length	16:21	arg1	Effect					0:5	Effect	0:5	Effect of amine length in the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads.	0:120	Effect of amine length in the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads.
33600890	2	30	theme	multipoint	595:604	arg1	attachment					615:624	the enzyme-support multipoint covalent attachment	576:624	the enzyme-support multipoint covalent attachment	576:624	As expected, the presence of amines reduced the intensity of the enzyme-support multipoint covalent attachment, and therefore the enzyme stability.
33600890	4	31	theme	presence	961:968	arg1	effect					947:952	the most important effect	928:952	the most important effect of the presence of aminated compounds	928:990	This way, it seems that the most important effect of the presence of aminated compounds came from the generation of steric hindrances to the enzyme/support multi-reaction promoted by the ammines that are interacting with the aldehyde groups.
33600890	0	32	theme	amine	10:14	arg1	length					16:21	amine length	10:21	amine length	10:21	Effect of amine length in the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads.
33600890	0	33	theme	agarose	107:113	arg1	beads					115:119	glyoxyl agarose beads	99:119	glyoxyl agarose beads	99:119	Effect of amine length in the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads.
33600890	0	34	from	immobilization	70:83	arg1	beads					115:119	glyoxyl agarose beads	99:119	glyoxyl agarose beads	99:119	Effect of amine length in the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads.
33600890	5	35	theme	compounds	1187:1195	arg1	1 mM					1170:1173	just 1 mM	1165:1173	just 1 mM of aminated compounds	1165:1195	In some instances, just 1 mM of aminated compounds is enough to greatly decrease enzyme stability.
33600890	4	36	theme	compounds	982:990	arg1	presence					961:968	the presence	957:968	the presence of aminated compounds	957:990	This way, it seems that the most important effect of the presence of aminated compounds came from the generation of steric hindrances to the enzyme/support multi-reaction promoted by the ammines that are interacting with the aldehyde groups.
33600890	1	37	from	10 mM	446:450	arg1	amine					369:373	hexyl amine	363:373	hexyl amine (at concentrations ranging from 0 to 20 mM)	363:417	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	37	from	10 mM	446:450	arg1	amine					429:433	octyl amine	423:433	octyl amine (from 0 to 10 mM)	423:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	37	from	10 mM	446:450	arg1	compounds					270:278	different aliphatic compounds	250:278	different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM)	250:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	37	from	10 mM	446:450	arg1	amine					343:347	ethyl amine	337:347	ethyl amine	337:347	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	37	from	10 mM	446:450	arg1	amine					356:360	butyl amine	350:360	butyl amine	350:360	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	3	38	theme	amine	814:818	arg1	presence					790:797	the presence	786:797	the presence of 10 mM octyl amine	786:818	However, it is clear that this effect is higher using octyl amine for all enzymes (in some cases the enzyme immobilized in the presence of 10 mM octyl amine was almost inactivated while the reference kept over 50 % of the initial activity).
33600890	1	39	theme	hexyl	363:367	arg1	amine					369:373	hexyl amine	363:373	hexyl amine (at concentrations ranging from 0 to 20 mM)	363:417	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	39	theme	hexyl	363:367	arg1	compounds					270:278	different aliphatic compounds	250:278	different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM)	250:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	4	40	theme	aminated	973:980	arg1	compounds					982:990	aminated compounds	973:990	aminated compounds	973:990	This way, it seems that the most important effect of the presence of aminated compounds came from the generation of steric hindrances to the enzyme/support multi-reaction promoted by the ammines that are interacting with the aldehyde groups.
33600890	1	41	theme	primary	290:296	arg1	group					304:308	a primary amine group	288:308	a primary amine group during the immobilization	288:334	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	3	42	theme	using	711:715	arg1	amine					723:727	higher using octyl amine	704:727	higher using octyl amine for all enzymes	704:743	However, it is clear that this effect is higher using octyl amine for all enzymes (in some cases the enzyme immobilized in the presence of 10 mM octyl amine was almost inactivated while the reference kept over 50 % of the initial activity).
33600890	2	43	theme	enzyme	645:650	arg1	stability					652:660	the enzyme stability	641:660	the enzyme stability	641:660	As expected, the presence of amines reduced the intensity of the enzyme-support multipoint covalent attachment, and therefore the enzyme stability.
33600890	1	44	theme	amine	298:302	arg1	group					304:308	a primary amine group	288:308	a primary amine group during the immobilization	288:334	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	0	45	from	Effect	0:5	arg1	interference					30:41	the interference	26:41	the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads	26:119	Effect of amine length in the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads.
33600890	1	46	dep	compounds	270:278	arg1	amine					369:373	hexyl amine	363:373	hexyl amine (at concentrations ranging from 0 to 20 mM)	363:417	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	46	dep	compounds	270:278	arg1	amine					429:433	octyl amine	423:433	octyl amine (from 0 to 10 mM)	423:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	46	dep	compounds	270:278	arg1	compounds					270:278	different aliphatic compounds	250:278	different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM)	250:451	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	46	dep	compounds	270:278	arg1	amine					343:347	ethyl amine	337:347	ethyl amine	337:347	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	46	dep	compounds	270:278	arg1	amine					356:360	butyl amine	350:360	butyl amine	350:360	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	1	47	dep	20 mM	412:416	arg1	to					409:410	to	409:410	to	409:410	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	4	48	theme	aldehyde	1129:1136	arg1	groups					1138:1143	the aldehyde groups	1125:1143	the aldehyde groups	1125:1143	This way, it seems that the most important effect of the presence of aminated compounds came from the generation of steric hindrances to the enzyme/support multi-reaction promoted by the ammines that are interacting with the aldehyde groups.
33600890	4	49	theme	important	937:945	arg1	effect					947:952	the most important effect	928:952	the most important effect of the presence of aminated compounds	928:990	This way, it seems that the most important effect of the presence of aminated compounds came from the generation of steric hindrances to the enzyme/support multi-reaction promoted by the ammines that are interacting with the aldehyde groups.
33600890	1	50	from	immobilization	208:221	arg1	agarose					234:240	glyoxyl agarose	226:240	glyoxyl agarose	226:240	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	4	51	theme	enzyme/support	1045:1058	arg1	multi-reaction					1060:1073	the enzyme/support multi-reaction	1041:1073	the enzyme/support multi-reaction promoted by the ammines that are interacting with the aldehyde groups	1041:1143	This way, it seems that the most important effect of the presence of aminated compounds came from the generation of steric hindrances to the enzyme/support multi-reaction promoted by the ammines that are interacting with the aldehyde groups.
33600890	4	52	theme	steric	1020:1025	arg1	hindrances					1027:1036	steric hindrances	1020:1036	steric hindrances	1020:1036	This way, it seems that the most important effect of the presence of aminated compounds came from the generation of steric hindrances to the enzyme/support multi-reaction promoted by the ammines that are interacting with the aldehyde groups.
33600890	6	53	theme	small	1339:1343	arg1	compounds					1354:1362	small aminated compounds	1339:1362	small aminated compounds	1339:1362	The results suggested that, if the composition of the enzyme extract is unknown, to eliminate small aminated compounds may be necessary to maximize the enzyme-support reaction.
33600890	2	54	theme	attachment	615:624	arg1	intensity					563:571	the intensity	559:571	the intensity of the enzyme-support multipoint covalent attachment	559:624	As expected, the presence of amines reduced the intensity of the enzyme-support multipoint covalent attachment, and therefore the enzyme stability.
33600890	2	54	theme	attachment	615:624	arg1	stability					652:660	the enzyme stability	641:660	the enzyme stability	641:660	As expected, the presence of amines reduced the intensity of the enzyme-support multipoint covalent attachment, and therefore the enzyme stability.
33600890	0	55	theme	multipoint	50:59	arg1	immobilization					70:83	the multipoint covalent immobilization	46:83	the multipoint covalent immobilization of enzymes on glyoxyl agarose beads	46:119	Effect of amine length in the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads.
33600890	1	56	from	effects	470:476	arg1	stability					504:512	the immobilized enzyme stability	481:512	the immobilized enzyme stability	481:512	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
33600890	5	57	theme	enzyme	1227:1232	arg1	stability					1234:1242	enzyme stability	1227:1242	enzyme stability	1227:1242	In some instances, just 1 mM of aminated compounds is enough to greatly decrease enzyme stability.
33600890	6	58	theme	aminated	1345:1352	arg1	compounds					1354:1362	small aminated compounds	1339:1362	small aminated compounds	1339:1362	The results suggested that, if the composition of the enzyme extract is unknown, to eliminate small aminated compounds may be necessary to maximize the enzyme-support reaction.
33600890	0	59	from	beads	115:119	arg1	interference					30:41	the interference	26:41	the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads	26:119	Effect of amine length in the interference of the multipoint covalent immobilization of enzymes on glyoxyl agarose beads.
33600890	3	60	theme	octyl	717:721	arg1	amine					723:727	higher using octyl amine	704:727	higher using octyl amine for all enzymes	704:743	However, it is clear that this effect is higher using octyl amine for all enzymes (in some cases the enzyme immobilized in the presence of 10 mM octyl amine was almost inactivated while the reference kept over 50 % of the initial activity).
33600890	6	61	theme	enzyme-support	1397:1410	arg1	reaction					1412:1419	the enzyme-support reaction	1393:1419	the enzyme-support reaction	1393:1419	The results suggested that, if the composition of the enzyme extract is unknown, to eliminate small aminated compounds may be necessary to maximize the enzyme-support reaction.
33600890	1	62	theme	glyoxyl	226:232	arg1	agarose					234:240	glyoxyl agarose	226:240	glyoxyl agarose	226:240	Trypsin, chymotrypsin, penicillin G acylase and ficin extract have been stabilized by immobilization on glyoxyl agarose, adding different aliphatic compounds bearing a primary amine group during the immobilization: ethyl amine, butyl amine, hexyl amine (at concentrations ranging from 0 to 20 mM) and octyl amine (from 0 to 10 mM) to analyze their effects on the immobilized enzyme stability.
34801624	4	0	theme	EDTA	982:985	arg1	EDTA					982:985	EDTA	982:985	EDTA	982:985	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	0	theme	EDTA	982:985	arg1	chitosan					950:957	chitosan	950:957	chitosan	950:957	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	0	theme	EDTA	982:985	arg1	groups					972:977	carboxyl groups	963:977	carboxyl groups of EDTA	963:985	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	0	theme	EDTA	982:985	arg1	groups					940:945	amino groups	934:945	amino groups of chitosan	934:957	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	3	1	theme	magnetic	508:515	arg1	ECMBB					543:547	ECMBB	543:547	ECMBB	543:547	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	3	1	theme	magnetic	508:515	arg1	biochar					524:530	chitosan bi-functionalized magnetic bamboo biochar adsorbent	481:540	chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB)	481:548	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	6	2	theme	saturated	1175:1183	arg1	ECMBB					1204:1208	ECMBB	1204:1208	ECMBB at 25 °C	1204:1217	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	2	theme	saturated	1175:1183	arg1	amounts					1193:1199	The saturated capture amounts	1171:1199	The saturated capture amounts of ECMBB at 25 °C	1171:1217	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	2	theme	saturated	1175:1183	arg1	305.4 mg g-1					1223:1234	305.4 mg g-1	1223:1234	305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively	1223:1492	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	1	3	theme	considerable	259:270	arg1	concern					272:278	considerable concern	259:278	considerable concern	259:278	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	9	4	theme	organic	1924:1930	arg1	pollutants					1945:1954	organic and metallic pollutants	1924:1954	organic and metallic pollutants from complex wastewater	1924:1978	This study lays the foundation for fabricating desired integrative biochar adsorbents in the simultaneous purification of organic and metallic pollutants from complex wastewater.
34801624	9	5	theme	metallic	1936:1943	arg1	pollutants					1945:1954	organic and metallic pollutants	1924:1954	organic and metallic pollutants from complex wastewater	1924:1978	This study lays the foundation for fabricating desired integrative biochar adsorbents in the simultaneous purification of organic and metallic pollutants from complex wastewater.
34801624	3	6	theme	coinstantaneous	570:584	arg1	adsorption					586:595	coinstantaneous adsorption	570:595	coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II))	570:654	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	6	7	dep	times	1350:1354	arg1	those					1356:1360	those	1356:1360	those	1356:1360	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	0	8	theme	heavy	118:122	arg1	metals					124:129	heavy metals	118:129	heavy metals	118:129	A versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar for simultaneous removal of methyl orange and heavy metals from complex wastewater.
34801624	5	9	theme	unitary	995:1001	arg1	system					1003:1008	the unitary system	991:1008	the unitary system	991:1008	In the unitary system, the removal of MO, Cd(II) and Zn(II) by three as-prepared adsorbents can be well illuminated by pseudo-second-order kinetic model and Langmuir isotherm theory.
34801624	1	10	theme	organic	196:202	arg1	dyes					204:207	organic dyes	196:207	organic dyes	196:207	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	7	11	contain	had	1632:1634	arg1	metals					1625:1630	coexisting heavy metals	1608:1630	coexisting heavy metals	1608:1630	Remarkably, in MO-metal binary system, coexisting MO visibly enhanced the adsorption of Cd(II) and Zn(II), while coexisting heavy metals had no significant impact on MO adsorption.
34801624	7	11	contain	had	1632:1634	arg2	impact					1651:1656	no significant impact	1636:1656	no significant impact	1636:1656	Remarkably, in MO-metal binary system, coexisting MO visibly enhanced the adsorption of Cd(II) and Zn(II), while coexisting heavy metals had no significant impact on MO adsorption.
34801624	3	12	theme	orange	607:612	arg1	adsorption					586:595	coinstantaneous adsorption	570:595	coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II))	570:654	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	4	13	theme	hydrogen	836:843	arg1	bonding					845:851	hydrogen bonding	836:851	hydrogen bonding	836:851	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	13	theme	hydrogen	836:843	arg1	attraction					824:833	electrostatic attraction	810:833	electrostatic attraction	810:833	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	7	14	theme	binary	1519:1524	arg1	system					1526:1531	MO-metal binary system	1510:1531	MO-metal binary system	1510:1531	Remarkably, in MO-metal binary system, coexisting MO visibly enhanced the adsorption of Cd(II) and Zn(II), while coexisting heavy metals had no significant impact on MO adsorption.
34801624	6	15	theme	bamboo	1459:1464	arg1	MBB					1475:1477	MBB	1475:1477	MBB	1475:1477	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	15	theme	bamboo	1459:1464	arg1	biochar					1466:1472	magnetic bamboo biochar	1450:1472	magnetic bamboo biochar (MBB)	1450:1478	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	16	theme	capture	1185:1191	arg1	ECMBB					1204:1208	ECMBB	1204:1208	ECMBB at 25 °C	1204:1217	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	16	theme	capture	1185:1191	arg1	amounts					1193:1199	The saturated capture amounts	1171:1199	The saturated capture amounts of ECMBB at 25 °C	1171:1217	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	16	theme	capture	1185:1191	arg1	305.4 mg g-1					1223:1234	305.4 mg g-1	1223:1234	305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively	1223:1492	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	17	theme	bamboo	1392:1397	arg1	CMBB					1408:1411	CMBB	1408:1411	CMBB	1408:1411	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	17	theme	bamboo	1392:1397	arg1	biochar					1399:1405	chitosan-modified magnetic bamboo biochar	1365:1405	chitosan-modified magnetic bamboo biochar (CMBB)	1365:1412	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	4	18	theme	metals	912:917	arg1	binding					892:898	the binding	888:898	the binding of cationic metals	888:917	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	8	19	from	loss	1720:1723	arg1	efficiency					1739:1748	adsorption efficiency	1728:1748	adsorption efficiency	1728:1748	Furthermore, ECMBB exhibited no significant loss in adsorption efficiency even after eight adsorption-desorption experiments.
34801624	1	20	theme	physicochemical	320:334	arg1	properties					336:345	physicochemical properties	320:345	physicochemical properties	320:345	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	6	21	theme	chitosan-modified	1365:1381	arg1	CMBB					1408:1411	CMBB	1408:1411	CMBB	1408:1411	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	21	theme	chitosan-modified	1365:1381	arg1	biochar					1399:1405	chitosan-modified magnetic bamboo biochar	1365:1405	chitosan-modified magnetic bamboo biochar (CMBB)	1365:1412	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	0	22	theme	simultaneous	76:87	arg1	removal					89:95	simultaneous removal	76:95	simultaneous removal of methyl orange and heavy metals from complex wastewater	76:153	A versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar for simultaneous removal of methyl orange and heavy metals from complex wastewater.
34801624	5	23	theme	isotherm	1154:1161	arg1	theory					1163:1168	Langmuir isotherm theory	1145:1168	Langmuir isotherm theory	1145:1168	In the unitary system, the removal of MO, Cd(II) and Zn(II) by three as-prepared adsorbents can be well illuminated by pseudo-second-order kinetic model and Langmuir isotherm theory.
34801624	4	24	theme	favorable	717:725	arg1	performance					746:756	favorable anionic MO removal performance	717:756	favorable anionic MO removal performance	717:756	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	2	25	theme	methods	386:392	arg1	methods					386:392	the few removal methods	370:392	the few removal methods	370:392	Adsorption, as one of the few removal methods, has attracted extensive attention and gained popularity.
34801624	2	25	theme	methods	386:392	arg1	one					363:365	one	363:365	one	363:365	Adsorption, as one of the few removal methods, has attracted extensive attention and gained popularity.
34801624	0	26	theme	orange	107:112	arg1	removal					89:95	simultaneous removal	76:95	simultaneous removal of methyl orange and heavy metals from complex wastewater	76:153	A versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar for simultaneous removal of methyl orange and heavy metals from complex wastewater.
34801624	5	27	theme	MO	1026:1027	arg1	removal					1015:1021	the removal	1011:1021	the removal of MO, Cd(II) and Zn(II) by three as-prepared adsorbents	1011:1078	In the unitary system, the removal of MO, Cd(II) and Zn(II) by three as-prepared adsorbents can be well illuminated by pseudo-second-order kinetic model and Langmuir isotherm theory.
34801624	7	28	theme	MO	1661:1662	arg1	adsorption					1664:1673	MO adsorption	1661:1673	MO adsorption	1661:1673	Remarkably, in MO-metal binary system, coexisting MO visibly enhanced the adsorption of Cd(II) and Zn(II), while coexisting heavy metals had no significant impact on MO adsorption.
34801624	4	29	theme	carboxyl	963:970	arg1	EDTA					982:985	EDTA	982:985	EDTA	982:985	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	29	theme	carboxyl	963:970	arg1	chitosan					950:957	chitosan	950:957	chitosan	950:957	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	29	theme	carboxyl	963:970	arg1	groups					972:977	carboxyl groups	963:977	carboxyl groups of EDTA	963:985	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	2	30	theme	few	374:376	arg1	methods					386:392	the few removal methods	370:392	the few removal methods	370:392	Adsorption, as one of the few removal methods, has attracted extensive attention and gained popularity.
34801624	6	31	from	25 °C	1213:1217	arg1	ECMBB					1204:1208	ECMBB	1204:1208	ECMBB at 25 °C	1204:1217	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	31	from	25 °C	1213:1217	arg1	amounts					1193:1199	The saturated capture amounts	1171:1199	The saturated capture amounts of ECMBB at 25 °C	1171:1217	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	31	from	25 °C	1213:1217	arg1	305.4 mg g-1					1223:1234	305.4 mg g-1	1223:1234	305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively	1223:1492	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	4	32	theme	as-synthesized	675:688	arg1	composites					696:705	the as-synthesized ECMBB composites	671:705	the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction,	671:872	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	2	33	theme	extensive	409:417	arg1	attention					419:427	extensive attention	409:427	extensive attention	409:427	Adsorption, as one of the few removal methods, has attracted extensive attention and gained popularity.
34801624	1	34	from	removal	185:191	arg1	wastewater					237:246	complex wastewater	229:246	complex wastewater	229:246	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	4	35	theme	bamboo	763:768	arg1	BB					779:780	BB	779:780	BB	779:780	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	35	theme	bamboo	763:768	arg1	biochar					770:776	bamboo biochar	763:776	bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction,	763:872	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	6	36	from	amounts	1193:1199	arg1	25 °C					1213:1217	25 °C	1213:1217	25 °C	1213:1217	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	4	37	theme	chitosan	950:957	arg1	EDTA					982:985	EDTA	982:985	EDTA	982:985	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	37	theme	chitosan	950:957	arg1	chitosan					950:957	chitosan	950:957	chitosan	950:957	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	37	theme	chitosan	950:957	arg1	groups					972:977	carboxyl groups	963:977	carboxyl groups of EDTA	963:985	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	37	theme	chitosan	950:957	arg1	groups					940:945	amino groups	934:945	amino groups of chitosan	934:957	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	3	38	theme	metals	629:634	arg1	adsorption					586:595	coinstantaneous adsorption	570:595	coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II))	570:654	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	0	39	theme	magnetic	48:55	arg1	biochar					64:70	magnetic bamboo biochar	48:70	magnetic bamboo biochar for simultaneous removal of methyl orange and heavy metals from complex wastewater	48:153	A versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar for simultaneous removal of methyl orange and heavy metals from complex wastewater.
34801624	7	40	theme	coexisting	1608:1617	arg1	metals					1625:1630	coexisting heavy metals	1608:1630	coexisting heavy metals	1608:1630	Remarkably, in MO-metal binary system, coexisting MO visibly enhanced the adsorption of Cd(II) and Zn(II), while coexisting heavy metals had no significant impact on MO adsorption.
34801624	3	41	theme	heavy	623:627	arg1	Zn					648:649	Zn	648:649	Zn(II)	648:653	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	3	41	theme	heavy	623:627	arg1	Cd					637:638	Cd(II)	637:642	Cd(II)	637:642	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	3	41	theme	heavy	623:627	arg1	metals					629:634	heavy metals	623:634	heavy metals (Cd(II) and Zn(II))	623:654	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	9	42	theme	desired	1849:1855	arg1	adsorbents					1877:1886	desired integrative biochar adsorbents	1849:1886	desired integrative biochar adsorbents	1849:1886	This study lays the foundation for fabricating desired integrative biochar adsorbents in the simultaneous purification of organic and metallic pollutants from complex wastewater.
34801624	4	43	theme	MO	735:736	arg1	performance					746:756	favorable anionic MO removal performance	717:756	favorable anionic MO removal performance	717:756	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	3	44	theme	versatile	462:470	arg1	EDTA					472:475	a versatile EDTA	460:475	a versatile EDTA	460:475	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	1	45	theme	heavy	213:217	arg1	metals					219:224	heavy metals	213:224	heavy metals	213:224	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	9	46	theme	biochar	1869:1875	arg1	adsorbents					1877:1886	desired integrative biochar adsorbents	1849:1886	desired integrative biochar adsorbents	1849:1886	This study lays the foundation for fabricating desired integrative biochar adsorbents in the simultaneous purification of organic and metallic pollutants from complex wastewater.
34801624	3	47	theme	bamboo	517:522	arg1	ECMBB					543:547	ECMBB	543:547	ECMBB	543:547	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	3	47	theme	bamboo	517:522	arg1	biochar					524:530	chitosan bi-functionalized magnetic bamboo biochar adsorbent	481:540	chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB)	481:548	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	5	48	theme	pseudo-second-order	1107:1125	arg1	model					1135:1139	pseudo-second-order kinetic model	1107:1139	pseudo-second-order kinetic model	1107:1139	In the unitary system, the removal of MO, Cd(II) and Zn(II) by three as-prepared adsorbents can be well illuminated by pseudo-second-order kinetic model and Langmuir isotherm theory.
34801624	7	49	theme	Cd	1583:1584	arg1	adsorption					1569:1578	the adsorption	1565:1578	the adsorption of Cd(II) and Zn(II)	1565:1599	Remarkably, in MO-metal binary system, coexisting MO visibly enhanced the adsorption of Cd(II) and Zn(II), while coexisting heavy metals had no significant impact on MO adsorption.
34801624	1	50	from	differences	305:315	arg1	properties					336:345	physicochemical properties	320:345	physicochemical properties	320:345	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	9	51	from	purification	1908:1919	arg1	wastewater					1969:1978	complex wastewater	1961:1978	complex wastewater	1961:1978	This study lays the foundation for fabricating desired integrative biochar adsorbents in the simultaneous purification of organic and metallic pollutants from complex wastewater.
34801624	3	52	theme	bi-functionalized	490:506	arg1	ECMBB					543:547	ECMBB	543:547	ECMBB	543:547	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	3	52	theme	bi-functionalized	490:506	arg1	biochar					524:530	chitosan bi-functionalized magnetic bamboo biochar adsorbent	481:540	chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB)	481:548	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	1	53	theme	complex	229:235	arg1	wastewater					237:246	complex wastewater	229:246	complex wastewater	229:246	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	9	54	theme	simultaneous	1895:1906	arg1	purification					1908:1919	the simultaneous purification	1891:1919	the simultaneous purification of organic and metallic pollutants from complex wastewater	1891:1978	This study lays the foundation for fabricating desired integrative biochar adsorbents in the simultaneous purification of organic and metallic pollutants from complex wastewater.
34801624	9	55	from	wastewater	1969:1978	arg1	pollutants					1945:1954	organic and metallic pollutants	1924:1954	organic and metallic pollutants from complex wastewater	1924:1978	This study lays the foundation for fabricating desired integrative biochar adsorbents in the simultaneous purification of organic and metallic pollutants from complex wastewater.
34801624	9	55	from	wastewater	1969:1978	arg1	purification					1908:1919	the simultaneous purification	1891:1919	the simultaneous purification of organic and metallic pollutants from complex wastewater	1891:1978	This study lays the foundation for fabricating desired integrative biochar adsorbents in the simultaneous purification of organic and metallic pollutants from complex wastewater.
34801624	4	56	theme	electrostatic	810:822	arg1	bonding					845:851	hydrogen bonding	836:851	hydrogen bonding	836:851	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	56	theme	electrostatic	810:822	arg1	interaction					861:871	π-π interaction	857:871	π-π interaction	857:871	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	56	theme	electrostatic	810:822	arg1	attraction					824:833	electrostatic attraction	810:833	electrostatic attraction	810:833	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	0	57	from	wastewater	144:153	arg1	removal					89:95	simultaneous removal	76:95	simultaneous removal of methyl orange and heavy metals from complex wastewater	76:153	A versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar for simultaneous removal of methyl orange and heavy metals from complex wastewater.
34801624	3	58	theme	adsorbent	532:540	arg1	ECMBB					543:547	ECMBB	543:547	ECMBB	543:547	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	3	58	theme	adsorbent	532:540	arg1	biochar					524:530	chitosan bi-functionalized magnetic bamboo biochar adsorbent	481:540	chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB)	481:548	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	1	59	theme	simultaneous	172:183	arg1	removal					185:191	the simultaneous removal	168:191	the simultaneous removal of organic dyes and heavy metals in complex wastewater	168:246	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	9	60	theme	pollutants	1945:1954	arg1	purification					1908:1919	the simultaneous purification	1891:1919	the simultaneous purification of organic and metallic pollutants from complex wastewater	1891:1978	This study lays the foundation for fabricating desired integrative biochar adsorbents in the simultaneous purification of organic and metallic pollutants from complex wastewater.
34801624	0	61	theme	metals	124:129	arg1	removal					89:95	simultaneous removal	76:95	simultaneous removal of methyl orange and heavy metals from complex wastewater	76:153	A versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar for simultaneous removal of methyl orange and heavy metals from complex wastewater.
34801624	4	62	theme	π-π	857:859	arg1	interaction					861:871	π-π interaction	857:871	π-π interaction	857:871	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	62	theme	π-π	857:859	arg1	attraction					824:833	electrostatic attraction	810:833	electrostatic attraction	810:833	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	9	63	theme	complex	1961:1967	arg1	wastewater					1969:1978	complex wastewater	1961:1978	complex wastewater	1961:1978	This study lays the foundation for fabricating desired integrative biochar adsorbents in the simultaneous purification of organic and metallic pollutants from complex wastewater.
34801624	0	64	theme	complex	136:142	arg1	wastewater					144:153	complex wastewater	136:153	complex wastewater	136:153	A versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar for simultaneous removal of methyl orange and heavy metals from complex wastewater.
34801624	3	65	theme	methyl	600:605	arg1	MO					615:616	MO	615:616	MO	615:616	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	3	65	theme	methyl	600:605	arg1	orange					607:612	methyl orange	600:612	methyl orange (MO)	600:617	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	1	66	theme	dyes	204:207	arg1	removal					185:191	the simultaneous removal	168:191	the simultaneous removal of organic dyes and heavy metals in complex wastewater	168:246	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	6	67	theme	ECMBB	1204:1208	arg1	ECMBB					1204:1208	ECMBB	1204:1208	ECMBB at 25 °C	1204:1217	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	67	theme	ECMBB	1204:1208	arg1	amounts					1193:1199	The saturated capture amounts	1171:1199	The saturated capture amounts of ECMBB at 25 °C	1171:1217	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	67	theme	ECMBB	1204:1208	arg1	305.4 mg g-1					1223:1234	305.4 mg g-1	1223:1234	305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively	1223:1492	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	7	68	theme	coexisting	1534:1543	arg1	MO					1545:1546	coexisting MO	1534:1546	coexisting MO	1534:1546	Remarkably, in MO-metal binary system, coexisting MO visibly enhanced the adsorption of Cd(II) and Zn(II), while coexisting heavy metals had no significant impact on MO adsorption.
34801624	6	69	theme	biochar	1399:1405	arg1	times					1435:1439	1.9, 6.1 and 5.4 times	1418:1439	1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB)	1418:1478	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	69	theme	biochar	1399:1405	arg1	times					1350:1354	1.3, 2.6 and 2.5 times	1333:1354	1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB)	1333:1412	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	69	theme	biochar	1399:1405	arg1	Zn					1287:1288	Zn(II)	1287:1292	Zn(II)	1287:1292	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	70	theme	magnetic	1450:1457	arg1	MBB					1475:1477	MBB	1475:1477	MBB	1475:1477	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	70	theme	magnetic	1450:1457	arg1	biochar					1466:1472	magnetic bamboo biochar	1450:1472	magnetic bamboo biochar (MBB)	1450:1478	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	71	theme	magnetic	1383:1390	arg1	CMBB					1408:1411	CMBB	1408:1411	CMBB	1408:1411	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	6	71	theme	magnetic	1383:1390	arg1	biochar					1399:1405	chitosan-modified magnetic bamboo biochar	1365:1405	chitosan-modified magnetic bamboo biochar (CMBB)	1365:1412	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	7	72	theme	MO-metal	1510:1517	arg1	system					1526:1531	MO-metal binary system	1510:1531	MO-metal binary system	1510:1531	Remarkably, in MO-metal binary system, coexisting MO visibly enhanced the adsorption of Cd(II) and Zn(II), while coexisting heavy metals had no significant impact on MO adsorption.
34801624	4	73	theme	cationic	903:910	arg1	metals					912:917	cationic metals	903:917	cationic metals	903:917	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	8	74	theme	significant	1708:1718	arg1	loss					1720:1723	no significant loss	1705:1723	no significant loss in adsorption efficiency	1705:1748	Furthermore, ECMBB exhibited no significant loss in adsorption efficiency even after eight adsorption-desorption experiments.
34801624	5	75	theme	Langmuir	1145:1152	arg1	theory					1163:1168	Langmuir isotherm theory	1145:1168	Langmuir isotherm theory	1145:1168	In the unitary system, the removal of MO, Cd(II) and Zn(II) by three as-prepared adsorbents can be well illuminated by pseudo-second-order kinetic model and Langmuir isotherm theory.
34801624	0	76	theme	methyl	100:105	arg1	orange					107:112	methyl orange	100:112	methyl orange	100:112	A versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar for simultaneous removal of methyl orange and heavy metals from complex wastewater.
34801624	4	77	theme	ECMBB	690:694	arg1	composites					696:705	the as-synthesized ECMBB composites	671:705	the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction,	671:872	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	1	78	theme	metals	219:224	arg1	removal					185:191	the simultaneous removal	168:191	the simultaneous removal of organic dyes and heavy metals in complex wastewater	168:246	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	2	79	theme	removal	378:384	arg1	methods					386:392	the few removal methods	370:392	the few removal methods	370:392	Adsorption, as one of the few removal methods, has attracted extensive attention and gained popularity.
34801624	0	80	theme	versatile	2:10	arg1	EDTA					12:15	A versatile EDTA	0:15	A versatile EDTA	0:15	A versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar for simultaneous removal of methyl orange and heavy metals from complex wastewater.
34801624	7	81	theme	significant	1639:1649	arg1	impact					1651:1656	no significant impact	1636:1656	no significant impact	1636:1656	Remarkably, in MO-metal binary system, coexisting MO visibly enhanced the adsorption of Cd(II) and Zn(II), while coexisting heavy metals had no significant impact on MO adsorption.
34801624	8	82	theme	adsorption-desorption	1767:1787	arg1	experiments					1789:1799	eight adsorption-desorption experiments	1761:1799	eight adsorption-desorption experiments	1761:1799	Furthermore, ECMBB exhibited no significant loss in adsorption efficiency even after eight adsorption-desorption experiments.
34801624	5	83	theme	as-prepared	1057:1067	arg1	adsorbents					1069:1078	three as-prepared adsorbents	1051:1078	three as-prepared adsorbents	1051:1078	In the unitary system, the removal of MO, Cd(II) and Zn(II) by three as-prepared adsorbents can be well illuminated by pseudo-second-order kinetic model and Langmuir isotherm theory.
34801624	7	84	theme	heavy	1619:1623	arg1	metals					1625:1630	coexisting heavy metals	1608:1630	coexisting heavy metals	1608:1630	Remarkably, in MO-metal binary system, coexisting MO visibly enhanced the adsorption of Cd(II) and Zn(II), while coexisting heavy metals had no significant impact on MO adsorption.
34801624	6	85	dep	times	1435:1439	arg1	those					1441:1445	those	1441:1445	those	1441:1445	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	4	86	theme	amino	934:938	arg1	EDTA					982:985	EDTA	982:985	EDTA	982:985	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	86	theme	amino	934:938	arg1	chitosan					950:957	chitosan	950:957	chitosan	950:957	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	4	86	theme	amino	934:938	arg1	groups					940:945	amino groups	934:945	amino groups of chitosan	934:957	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	1	87	attach	removal	185:191	arg2	dyes					204:207	organic dyes	196:207	organic dyes	196:207	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	1	87	attach	removal	185:191	arg3	wastewater					237:246	complex wastewater	229:246	complex wastewater	229:246	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	1	87	attach	removal	185:191	arg2	metals					219:224	heavy metals	213:224	heavy metals	213:224	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	8	88	theme	adsorption	1728:1737	arg1	efficiency					1739:1748	adsorption efficiency	1728:1748	adsorption efficiency	1728:1748	Furthermore, ECMBB exhibited no significant loss in adsorption efficiency even after eight adsorption-desorption experiments.
34801624	0	89	theme	bamboo	57:62	arg1	biochar					64:70	magnetic bamboo biochar	48:70	magnetic bamboo biochar for simultaneous removal of methyl orange and heavy metals from complex wastewater	48:153	A versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar for simultaneous removal of methyl orange and heavy metals from complex wastewater.
34801624	1	90	theme	striking	296:303	arg1	differences					305:315	their striking differences	290:315	their striking differences in physicochemical properties	290:345	At present, the simultaneous removal of organic dyes and heavy metals in complex wastewater has raised considerable concern, owing to their striking differences in physicochemical properties.
34801624	3	91	theme	chitosan	481:488	arg1	ECMBB					543:547	ECMBB	543:547	ECMBB	543:547	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	3	91	theme	chitosan	481:488	arg1	biochar					524:530	chitosan bi-functionalized magnetic bamboo biochar adsorbent	481:540	chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB)	481:548	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	7	92	theme	Zn	1594:1595	arg1	adsorption					1569:1578	the adsorption	1565:1578	the adsorption of Cd(II) and Zn(II)	1565:1599	Remarkably, in MO-metal binary system, coexisting MO visibly enhanced the adsorption of Cd(II) and Zn(II), while coexisting heavy metals had no significant impact on MO adsorption.
34801624	9	93	theme	integrative	1857:1867	arg1	adsorbents					1877:1886	desired integrative biochar adsorbents	1849:1886	desired integrative biochar adsorbents	1849:1886	This study lays the foundation for fabricating desired integrative biochar adsorbents in the simultaneous purification of organic and metallic pollutants from complex wastewater.
34801624	4	94	theme	anionic	727:733	arg1	performance					746:756	favorable anionic MO removal performance	717:756	favorable anionic MO removal performance	717:756	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	6	95	theme	same	1312:1315	arg1	conditions					1317:1326	the same conditions	1308:1326	the same conditions	1308:1326	The saturated capture amounts of ECMBB at 25 °C are 305.4 mg g-1 for MO, 63.2 mg g-1 for Cd(II) and 50.8 mg g-1 for Zn(II), which, under the same conditions, are 1.3, 2.6 and 2.5 times those of chitosan-modified magnetic bamboo biochar (CMBB) and 1.9, 6.1 and 5.4 times those of magnetic bamboo biochar (MBB), respectively.
34801624	3	96	dep	metals	629:634	arg1	II					651:652	II	651:652	II	651:652	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	3	96	dep	metals	629:634	arg1	Zn					648:649	Zn	648:649	Zn(II)	648:653	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	3	96	dep	metals	629:634	arg1	Cd					637:638	Cd(II)	637:642	Cd(II)	637:642	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	3	96	dep	metals	629:634	arg1	metals					629:634	heavy metals	623:634	heavy metals (Cd(II) and Zn(II))	623:654	Herein, a versatile EDTA and chitosan bi-functionalized magnetic bamboo biochar adsorbent (ECMBB) was synthesized for coinstantaneous adsorption of methyl orange (MO) and heavy metals (Cd(II) and Zn(II)).
34801624	4	97	theme	removal	738:744	arg1	performance					746:756	favorable anionic MO removal performance	717:756	favorable anionic MO removal performance	717:756	In this case, the as-synthesized ECMBB composites inherited favorable anionic MO removal performance from bamboo biochar (BB) obtained at 700 °C through electrostatic attraction, hydrogen bonding and π-π interaction, also enhanced the binding of cationic metals by introducing amino groups of chitosan and carboxyl groups of EDTA.
34801624	5	98	theme	kinetic	1127:1133	arg1	model					1135:1139	pseudo-second-order kinetic model	1107:1139	pseudo-second-order kinetic model	1107:1139	In the unitary system, the removal of MO, Cd(II) and Zn(II) by three as-prepared adsorbents can be well illuminated by pseudo-second-order kinetic model and Langmuir isotherm theory.
33529630	2	0	theme	trihydrate	533:542	arg1	performance					503:513	the performance	499:513	the performance of sodium acetate trihydrate (SAT)	499:548	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	9	1	theme	satisfying	1402:1411	arg1	reliability					1421:1431	satisfying thermal reliability	1402:1431	satisfying thermal reliability	1402:1431	The enthalpy of this composite decreased only around 2% after 100 melting/freezing cycles, showing satisfying thermal reliability.
33529630	6	2	theme	@	929:929	arg1	composite					945:953	the prepared PCM@CNF/AgNPs 0.02 composite	913:953	the prepared PCM@CNF/AgNPs 0.02 composite	913:953	Differential scanning calorimetry results indicated that the prepared PCM@CNF/AgNPs 0.02 composite showed a similar melting point (57.4 °C) and enthalpy (269 kJ/kg), compared to those of pure SAT.
33529630	2	3	theme	acetate	525:531	arg1	SAT					545:547	SAT	545:547	SAT	545:547	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	2	3	theme	acetate	525:531	arg1	trihydrate					533:542	sodium acetate trihydrate	518:542	sodium acetate trihydrate (SAT)	518:548	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	4	4	dep	CNF/AgNPs	675:683	arg1	dodecahydrate					717:729	dibasic dodecahydrate	709:729	dibasic dodecahydrate	709:729	Through the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate, a low supercooling degree of 1.2 °C was achieved.
33529630	1	5	theme	supercooling	217:228	arg1	challenge					204:212	the challenge	200:212	the challenge of supercooling, which must be addressed to allow more efficient energy storage and utilisation	200:308	Salt hydrate phase change materials (PCMs) possess the challenge of supercooling, which must be addressed to allow more efficient energy storage and utilisation.
33529630	2	6	theme	synthesised	447:457	arg1	composite					469:477	the synthesised CNF/AgNPs composite	443:477	the synthesised CNF/AgNPs composite	443:477	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	2	7	theme	sodium	518:523	arg1	SAT					545:547	SAT	545:547	SAT	545:547	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	2	7	theme	sodium	518:523	arg1	trihydrate					533:542	sodium acetate trihydrate	518:542	sodium acetate trihydrate (SAT)	518:548	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	4	8	theme	supercooling	738:749	arg1	degree					751:756	a low supercooling degree	732:756	a low supercooling degree of 1.2 °C	732:766	Through the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate, a low supercooling degree of 1.2 °C was achieved.
33529630	8	9	theme	@	1242:1242	arg1	composite					1258:1266	PCM@CNF/AgNPs 0.02 composite	1239:1266	PCM@CNF/AgNPs 0.02 composite	1239:1266	The thermal conductivity of PCM@CNF/AgNPs 0.02 composite was 31.6% higher than that of SAT.
33529630	6	10	theme	prepared	917:924	arg1	composite					945:953	the prepared PCM@CNF/AgNPs 0.02 composite	913:953	the prepared PCM@CNF/AgNPs 0.02 composite	913:953	Differential scanning calorimetry results indicated that the prepared PCM@CNF/AgNPs 0.02 composite showed a similar melting point (57.4 °C) and enthalpy (269 kJ/kg), compared to those of pure SAT.
33529630	0	11	theme	composite	63:71	arg1	AgNPs					56:60	AgNPs	56:60	AgNPs	56:60	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	0	11	theme	composite	63:71	arg1	nanoparticles					41:53	nanoparticles	41:53	nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage	41:146	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	10	12	used	used	1466:1469	arg2	composite					1439:1447	This composite	1434:1447	This composite	1434:1447	This composite can therefore be used to fabricate high-performance TES systems with negligible supercooling and improved thermal properties.
33529630	8	13	theme	PCM	1239:1241	arg1	composite					1258:1266	PCM@CNF/AgNPs 0.02 composite	1239:1266	PCM@CNF/AgNPs 0.02 composite	1239:1266	The thermal conductivity of PCM@CNF/AgNPs 0.02 composite was 31.6% higher than that of SAT.
33529630	4	14	theme	CNF/AgNPs	675:683	arg1	effect					662:667	the synergistic effect	646:667	the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate	646:729	Through the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate, a low supercooling degree of 1.2 °C was achieved.
33529630	2	15	used	used	483:486	arg2	composite					469:477	the synthesised CNF/AgNPs composite	443:477	the synthesised CNF/AgNPs composite	443:477	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	0	16	theme	hydrate	81:87	arg1	material					102:109	salt hydrate phase change material	76:109	salt hydrate phase change material for efficient thermal energy storage	76:146	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	6	17	theme	melting	972:978	arg1	57.4 °C					987:993	57.4 °C	987:993	57.4 °C	987:993	Differential scanning calorimetry results indicated that the prepared PCM@CNF/AgNPs 0.02 composite showed a similar melting point (57.4 °C) and enthalpy (269 kJ/kg), compared to those of pure SAT.
33529630	6	17	theme	melting	972:978	arg1	point					980:984	a similar melting point	962:984	a similar melting point (57.4 °C)	962:994	Differential scanning calorimetry results indicated that the prepared PCM@CNF/AgNPs 0.02 composite showed a similar melting point (57.4 °C) and enthalpy (269 kJ/kg), compared to those of pure SAT.
33529630	4	18	theme	%	690:690	arg1	phosphate					699:707	2% sodium phosphate	689:707	2% sodium phosphate	689:707	Through the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate, a low supercooling degree of 1.2 °C was achieved.
33529630	5	19	theme	prepared	832:839	arg1	composite					845:853	the prepared PCM composite	828:853	the prepared PCM composite	828:853	Moreover, AgNPs were uniformly distributed in the prepared PCM composite.
33529630	0	20	theme	salt	76:79	arg1	material					102:109	salt hydrate phase change material	76:109	salt hydrate phase change material for efficient thermal energy storage	76:146	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	2	21	used	used	380:383	arg2	biopolymer					365:374	a versatile biopolymer	353:374	a versatile biopolymer	353:374	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	2	21	used	used	380:383	arg2	CNF					347:349	CNF	347:349	CNF	347:349	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	2	21	used	used	380:383	arg2	nanofibril					335:344	cellulose nanofibril	325:344	cellulose nanofibril (CNF)	325:350	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	8	22	theme	CNF/AgNPs	1243:1251	arg1	composite					1258:1266	PCM@CNF/AgNPs 0.02 composite	1239:1266	PCM@CNF/AgNPs 0.02 composite	1239:1266	The thermal conductivity of PCM@CNF/AgNPs 0.02 composite was 31.6% higher than that of SAT.
33529630	4	23	theme	2	689:689	arg1	%					690:690	%	690:690	%	690:690	Through the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate, a low supercooling degree of 1.2 °C was achieved.
33529630	1	24	theme	Salt	149:152	arg1	PCMs					186:189	Salt hydrate phase change materials (PCMs)	149:190	Salt hydrate phase change materials (PCMs)	149:190	Salt hydrate phase change materials (PCMs) possess the challenge of supercooling, which must be addressed to allow more efficient energy storage and utilisation.
33529630	10	25	theme	TES	1501:1503	arg1	systems					1505:1511	high-performance TES systems	1484:1511	high-performance TES systems	1484:1511	This composite can therefore be used to fabricate high-performance TES systems with negligible supercooling and improved thermal properties.
33529630	7	26	theme	160 °C	1167:1172	arg1	temperature					1152:1162	a heating temperature	1142:1162	a heating temperature of 160 °C	1142:1172	Thermogravimetric analysis showed that the PCM composite did not lose all moisture until a heating temperature of 160 °C, showing improved thermal stability.
33529630	1	27	theme	hydrate	154:160	arg1	PCMs					186:189	Salt hydrate phase change materials (PCMs)	149:190	Salt hydrate phase change materials (PCMs)	149:190	Salt hydrate phase change materials (PCMs) possess the challenge of supercooling, which must be addressed to allow more efficient energy storage and utilisation.
33529630	10	28	theme	high-performance	1484:1499	arg1	systems					1505:1511	high-performance TES systems	1484:1511	high-performance TES systems	1484:1511	This composite can therefore be used to fabricate high-performance TES systems with negligible supercooling and improved thermal properties.
33529630	9	29	theme	melting/freezing	1369:1384	arg1	cycles					1386:1391	100 melting/freezing cycles	1365:1391	100 melting/freezing cycles	1365:1391	The enthalpy of this composite decreased only around 2% after 100 melting/freezing cycles, showing satisfying thermal reliability.
33529630	4	30	theme	1.2 °C	761:766	arg1	degree					751:756	a low supercooling degree	732:756	a low supercooling degree of 1.2 °C	732:766	Through the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate, a low supercooling degree of 1.2 °C was achieved.
33529630	8	31	theme	composite	1258:1266	arg1	higher					1278:1283	higher	1278:1283	higher	1278:1283	The thermal conductivity of PCM@CNF/AgNPs 0.02 composite was 31.6% higher than that of SAT.
33529630	8	31	theme	composite	1258:1266	arg1	conductivity					1223:1234	The thermal conductivity	1211:1234	The thermal conductivity of PCM@CNF/AgNPs 0.02 composite	1211:1266	The thermal conductivity of PCM@CNF/AgNPs 0.02 composite was 31.6% higher than that of SAT.
33529630	7	32	theme	thermal	1192:1198	arg1	stability					1200:1208	improved thermal stability	1183:1208	improved thermal stability	1183:1208	Thermogravimetric analysis showed that the PCM composite did not lose all moisture until a heating temperature of 160 °C, showing improved thermal stability.
33529630	1	33	theme	phase	162:166	arg1	PCMs					186:189	Salt hydrate phase change materials (PCMs)	149:190	Salt hydrate phase change materials (PCMs)	149:190	Salt hydrate phase change materials (PCMs) possess the challenge of supercooling, which must be addressed to allow more efficient energy storage and utilisation.
33529630	0	34	theme	nanofibril	17:26	arg1	Use					0:2	Use	0:2	Use of cellulose nanofibril (CNF)	0:32	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	0	35	theme	change	95:100	arg1	material					102:109	salt hydrate phase change material	76:109	salt hydrate phase change material for efficient thermal energy storage	76:146	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	10	36	theme	improved	1546:1553	arg1	properties					1563:1572	improved thermal properties	1546:1572	improved thermal properties	1546:1572	This composite can therefore be used to fabricate high-performance TES systems with negligible supercooling and improved thermal properties.
33529630	4	37	theme	%	673:673	arg1	CNF/AgNPs					675:683	1% CNF/AgNPs	672:683	1% CNF/AgNPs	672:683	Through the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate, a low supercooling degree of 1.2 °C was achieved.
33529630	1	38	theme	change	168:173	arg1	PCMs					186:189	Salt hydrate phase change materials (PCMs)	149:190	Salt hydrate phase change materials (PCMs)	149:190	Salt hydrate phase change materials (PCMs) possess the challenge of supercooling, which must be addressed to allow more efficient energy storage and utilisation.
33529630	0	39	theme	cellulose	7:15	arg1	CNF					29:31	CNF	29:31	CNF	29:31	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	0	39	theme	cellulose	7:15	arg1	nanofibril					17:26	cellulose nanofibril	7:26	cellulose nanofibril (CNF)	7:32	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	0	40	theme	phase	89:93	arg1	material					102:109	salt hydrate phase change material	76:109	salt hydrate phase change material for efficient thermal energy storage	76:146	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	4	41	theme	1	672:672	arg1	%					673:673	%	673:673	%	673:673	Through the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate, a low supercooling degree of 1.2 °C was achieved.
33529630	9	42	theme	thermal	1413:1419	arg1	reliability					1421:1431	satisfying thermal reliability	1402:1431	satisfying thermal reliability	1402:1431	The enthalpy of this composite decreased only around 2% after 100 melting/freezing cycles, showing satisfying thermal reliability.
33529630	1	43	theme	materials	175:183	arg1	PCMs					186:189	Salt hydrate phase change materials (PCMs)	149:190	Salt hydrate phase change materials (PCMs)	149:190	Salt hydrate phase change materials (PCMs) possess the challenge of supercooling, which must be addressed to allow more efficient energy storage and utilisation.
33529630	2	44	theme	silver	409:414	arg1	AgNPs					431:435	AgNPs	431:435	AgNPs	431:435	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	2	44	theme	silver	409:414	arg1	nanoparticles					416:428	silver nanoparticles	409:428	silver nanoparticles (AgNPs)	409:436	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	6	45	theme	calorimetry	878:888	arg1	results					890:896	Differential scanning calorimetry results	856:896	Differential scanning calorimetry results	856:896	Differential scanning calorimetry results indicated that the prepared PCM@CNF/AgNPs 0.02 composite showed a similar melting point (57.4 °C) and enthalpy (269 kJ/kg), compared to those of pure SAT.
33529630	7	46	theme	improved	1183:1190	arg1	stability					1200:1208	improved thermal stability	1183:1208	improved thermal stability	1183:1208	Thermogravimetric analysis showed that the PCM composite did not lose all moisture until a heating temperature of 160 °C, showing improved thermal stability.
33529630	8	47	theme	thermal	1215:1221	arg1	higher					1278:1283	higher	1278:1283	higher	1278:1283	The thermal conductivity of PCM@CNF/AgNPs 0.02 composite was 31.6% higher than that of SAT.
33529630	8	47	theme	thermal	1215:1221	arg1	conductivity					1223:1234	The thermal conductivity	1211:1234	The thermal conductivity of PCM@CNF/AgNPs 0.02 composite	1211:1266	The thermal conductivity of PCM@CNF/AgNPs 0.02 composite was 31.6% higher than that of SAT.
33529630	2	48	theme	cellulose	325:333	arg1	biopolymer					365:374	a versatile biopolymer	353:374	a versatile biopolymer	353:374	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	2	48	theme	cellulose	325:333	arg1	CNF					347:349	CNF	347:349	CNF	347:349	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	2	48	theme	cellulose	325:333	arg1	nanofibril					335:344	cellulose nanofibril	325:344	cellulose nanofibril (CNF)	325:350	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	6	49	theme	similar	964:970	arg1	57.4 °C					987:993	57.4 °C	987:993	57.4 °C	987:993	Differential scanning calorimetry results indicated that the prepared PCM@CNF/AgNPs 0.02 composite showed a similar melting point (57.4 °C) and enthalpy (269 kJ/kg), compared to those of pure SAT.
33529630	6	49	theme	similar	964:970	arg1	point					980:984	a similar melting point	962:984	a similar melting point (57.4 °C)	962:994	Differential scanning calorimetry results indicated that the prepared PCM@CNF/AgNPs 0.02 composite showed a similar melting point (57.4 °C) and enthalpy (269 kJ/kg), compared to those of pure SAT.
33529630	10	50	theme	negligible	1518:1527	arg1	supercooling					1529:1540	negligible supercooling	1518:1540	negligible supercooling	1518:1540	This composite can therefore be used to fabricate high-performance TES systems with negligible supercooling and improved thermal properties.
33529630	6	51	theme	scanning	869:876	arg1	calorimetry					878:888	Differential scanning calorimetry	856:888	Differential scanning calorimetry results	856:896	Differential scanning calorimetry results indicated that the prepared PCM@CNF/AgNPs 0.02 composite showed a similar melting point (57.4 °C) and enthalpy (269 kJ/kg), compared to those of pure SAT.
33529630	2	52	theme	CNF/AgNPs	459:467	arg1	composite					469:477	the synthesised CNF/AgNPs composite	443:477	the synthesised CNF/AgNPs composite	443:477	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	6	53	theme	PCM	926:928	arg1	composite					945:953	the prepared PCM@CNF/AgNPs 0.02 composite	913:953	the prepared PCM@CNF/AgNPs 0.02 composite	913:953	Differential scanning calorimetry results indicated that the prepared PCM@CNF/AgNPs 0.02 composite showed a similar melting point (57.4 °C) and enthalpy (269 kJ/kg), compared to those of pure SAT.
33529630	7	54	theme	Thermogravimetric	1053:1069	arg1	analysis					1071:1078	Thermogravimetric analysis	1053:1078	Thermogravimetric analysis	1053:1078	Thermogravimetric analysis showed that the PCM composite did not lose all moisture until a heating temperature of 160 °C, showing improved thermal stability.
33529630	7	55	theme	PCM	1096:1098	arg1	composite					1100:1108	the PCM composite	1092:1108	the PCM composite	1092:1108	Thermogravimetric analysis showed that the PCM composite did not lose all moisture until a heating temperature of 160 °C, showing improved thermal stability.
33529630	6	56	theme	Differential	856:867	arg1	calorimetry					878:888	Differential scanning calorimetry	856:888	Differential scanning calorimetry results	856:896	Differential scanning calorimetry results indicated that the prepared PCM@CNF/AgNPs 0.02 composite showed a similar melting point (57.4 °C) and enthalpy (269 kJ/kg), compared to those of pure SAT.
33529630	0	57	theme	thermal	125:131	arg1	storage					140:146	efficient thermal energy storage	115:146	efficient thermal energy storage	115:146	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	1	58	contain	possess	192:198	arg2	challenge					204:212	the challenge	200:212	the challenge of supercooling, which must be addressed to allow more efficient energy storage and utilisation	200:308	Salt hydrate phase change materials (PCMs) possess the challenge of supercooling, which must be addressed to allow more efficient energy storage and utilisation.
33529630	1	58	contain	possess	192:198	arg1	PCMs					186:189	Salt hydrate phase change materials (PCMs)	149:190	Salt hydrate phase change materials (PCMs)	149:190	Salt hydrate phase change materials (PCMs) possess the challenge of supercooling, which must be addressed to allow more efficient energy storage and utilisation.
33529630	1	59	theme	efficient	269:277	arg1	storage					286:292	more efficient energy storage	264:292	more efficient energy storage	264:292	Salt hydrate phase change materials (PCMs) possess the challenge of supercooling, which must be addressed to allow more efficient energy storage and utilisation.
33529630	0	60	theme	efficient	115:123	arg1	storage					140:146	efficient thermal energy storage	115:146	efficient thermal energy storage	115:146	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	4	61	theme	low	734:736	arg1	degree					751:756	a low supercooling degree	732:756	a low supercooling degree of 1.2 °C	732:766	Through the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate, a low supercooling degree of 1.2 °C was achieved.
33529630	1	62	theme	energy	279:284	arg1	storage					286:292	more efficient energy storage	264:292	more efficient energy storage	264:292	Salt hydrate phase change materials (PCMs) possess the challenge of supercooling, which must be addressed to allow more efficient energy storage and utilisation.
33529630	4	63	theme	phosphate	699:707	arg1	effect					662:667	the synergistic effect	646:667	the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate	646:729	Through the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate, a low supercooling degree of 1.2 °C was achieved.
33529630	4	64	theme	synergistic	650:660	arg1	effect					662:667	the synergistic effect	646:667	the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate	646:729	Through the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate, a low supercooling degree of 1.2 °C was achieved.
33529630	6	65	theme	pure	1043:1046	arg1	SAT					1048:1050	pure SAT	1043:1050	pure SAT	1043:1050	Differential scanning calorimetry results indicated that the prepared PCM@CNF/AgNPs 0.02 composite showed a similar melting point (57.4 °C) and enthalpy (269 kJ/kg), compared to those of pure SAT.
33529630	0	66	theme	energy	133:138	arg1	storage					140:146	efficient thermal energy storage	115:146	efficient thermal energy storage	115:146	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	4	67	theme	sodium	692:697	arg1	phosphate					699:707	2% sodium phosphate	689:707	2% sodium phosphate	689:707	Through the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate, a low supercooling degree of 1.2 °C was achieved.
33529630	5	68	theme	PCM	841:843	arg1	composite					845:853	the prepared PCM composite	828:853	the prepared PCM composite	828:853	Moreover, AgNPs were uniformly distributed in the prepared PCM composite.
33529630	0	69	from	material	102:109	arg1	composite					63:71	composite	63:71	composite	63:71	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	0	70	from	composite	63:71	arg1	material					102:109	salt hydrate phase change material	76:109	salt hydrate phase change material for efficient thermal energy storage	76:146	Use of cellulose nanofibril (CNF)/silver nanoparticles (AgNPs) composite in salt hydrate phase change material for efficient thermal energy storage.
33529630	2	71	theme	versatile	355:363	arg1	biopolymer					365:374	a versatile biopolymer	353:374	a versatile biopolymer	353:374	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	2	71	theme	versatile	355:363	arg1	nanofibril					335:344	cellulose nanofibril	325:344	cellulose nanofibril (CNF)	325:350	In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs composite was used to improve the performance of sodium acetate trihydrate (SAT).
33529630	7	72	theme	heating	1144:1150	arg1	temperature					1152:1162	a heating temperature	1142:1162	a heating temperature of 160 °C	1142:1172	Thermogravimetric analysis showed that the PCM composite did not lose all moisture until a heating temperature of 160 °C, showing improved thermal stability.
33529630	10	73	theme	thermal	1555:1561	arg1	properties					1563:1572	improved thermal properties	1546:1572	improved thermal properties	1546:1572	This composite can therefore be used to fabricate high-performance TES systems with negligible supercooling and improved thermal properties.
33529630	9	74	theme	composite	1324:1332	arg1	enthalpy					1307:1314	The enthalpy	1303:1314	The enthalpy of this composite	1303:1332	The enthalpy of this composite decreased only around 2% after 100 melting/freezing cycles, showing satisfying thermal reliability.
33529630	4	75	theme	dibasic	709:715	arg1	dodecahydrate					717:729	dibasic dodecahydrate	709:729	dibasic dodecahydrate	709:729	Through the synergistic effect of 1% CNF/AgNPs and 2% sodium phosphate dibasic dodecahydrate, a low supercooling degree of 1.2 °C was achieved.
33529630	6	76	theme	CNF/AgNPs	930:938	arg1	composite					945:953	the prepared PCM@CNF/AgNPs 0.02 composite	913:953	the prepared PCM@CNF/AgNPs 0.02 composite	913:953	Differential scanning calorimetry results indicated that the prepared PCM@CNF/AgNPs 0.02 composite showed a similar melting point (57.4 °C) and enthalpy (269 kJ/kg), compared to those of pure SAT.
33507748	4	0	theme	particles	576:584	arg1	size					558:561	size	558:561	size	558:561	The size and shape of particles were monitored via scanning electron microscopy and X-ray micro-computed tomography.
33507748	4	0	theme	particles	576:584	arg1	shape					567:571	shape	567:571	shape	567:571	The size and shape of particles were monitored via scanning electron microscopy and X-ray micro-computed tomography.
33507748	8	1	theme	ink	1156:1158	arg1	application					1136:1146	application	1136:1146	application of this ink	1136:1158	With application of this ink, cytocompatibility was proven in indirect cell culture and bioplotting experiments using a human mesenchymal stem cell line.
33507748	9	2	theme	cell-laden	1311:1320	arg1	scaffolds					1322:1330	cell-laden scaffolds	1311:1330	cell-laden scaffolds	1311:1330	Toward the deformation of cell-laden scaffolds to support cell differentiation in the future, radiography allowed the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field.
33507748	5	3	theme	Shear-thinning	671:684	arg1	properties					686:695	Shear-thinning properties	671:695	Shear-thinning properties of the algMC ink	671:712	Shear-thinning properties of the algMC ink were maintained after the addition of different concentrations of magnetite microparticles to the ink.
33507748	7	4	theme	w/w	1105:1107	arg1	%					1103:1103	25% w/w	1101:1107	25% w/w	1101:1107	The printability and shape fidelity of various shapes were evaluated, so that the final composition of algMC + 25% w/w magnetite was chosen.
33507748	1	5	theme	chondrogenic	171:182	arg1	differentiation					184:198	differentiation	184:198	differentiation	184:198	Mechanical stimulation of cells embedded in scaffolds is known to increase the cellular performance toward osteogenic or chondrogenic differentiation and tissue development.
33507748	6	6	theme	magnetization	927:939	arg1	level					907:911	the level	903:911	the level of saturation magnetization	903:939	Its viscosity proportionally increased with the added amount of magnetite, and so did the level of saturation magnetization as determined via vibrating sample magnetometry.
33507748	2	7	theme	scaffold	360:367	arg1	regions					369:375	magnetically inducible scaffold regions	337:375	magnetically inducible scaffold regions	337:375	Three-dimensional bioplotting of magnetically deformable scaffolds enables the spatially defined distribution of magnetically inducible scaffold regions.
33507748	9	8	theme	scaffolds	1463:1471	arg1	deformation					1448:1458	magnetically induced deformation	1427:1458	magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations	1427:1529	Toward the deformation of cell-laden scaffolds to support cell differentiation in the future, radiography allowed the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field.
33507748	5	9	theme	different	752:760	arg1	concentrations					762:775	different concentrations	752:775	different concentrations of magnetite microparticles	752:803	Shear-thinning properties of the algMC ink were maintained after the addition of different concentrations of magnetite microparticles to the ink.
33507748	6	10	theme	saturation	916:925	arg1	magnetization					927:939	saturation magnetization	916:939	saturation magnetization	916:939	Its viscosity proportionally increased with the added amount of magnetite, and so did the level of saturation magnetization as determined via vibrating sample magnetometry.
33507748	1	11	theme	cells	76:80	arg1	stimulation					61:71	Mechanical stimulation	50:71	Mechanical stimulation of cells embedded in scaffolds	50:102	Mechanical stimulation of cells embedded in scaffolds is known to increase the cellular performance toward osteogenic or chondrogenic differentiation and tissue development.
33507748	2	12	theme	inducible	350:358	arg1	regions					369:375	magnetically inducible scaffold regions	337:375	magnetically inducible scaffold regions	337:375	Three-dimensional bioplotting of magnetically deformable scaffolds enables the spatially defined distribution of magnetically inducible scaffold regions.
33507748	5	13	theme	concentrations	762:775	arg1	addition					740:747	the addition	736:747	the addition of different concentrations of magnetite microparticles to the ink	736:814	Shear-thinning properties of the algMC ink were maintained after the addition of different concentrations of magnetite microparticles to the ink.
33507748	7	14	theme	magnetite	1109:1117	arg1	composition					1078:1088	the final composition	1068:1088	the final composition of algMC + 25% w/w magnetite	1068:1117	The printability and shape fidelity of various shapes were evaluated, so that the final composition of algMC + 25% w/w magnetite was chosen.
33507748	9	15	theme	orientations	1518:1529	arg1	scaffolds					1463:1471	scaffolds	1463:1471	scaffolds of different pore architectures and scaffold orientations	1463:1529	Toward the deformation of cell-laden scaffolds to support cell differentiation in the future, radiography allowed the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field.
33507748	1	16	theme	embedded	82:89	arg1	cells					76:80	cells	76:80	cells embedded in scaffolds	76:102	Mechanical stimulation of cells embedded in scaffolds is known to increase the cellular performance toward osteogenic or chondrogenic differentiation and tissue development.
33507748	8	17	theme	cell	1274:1277	arg1	line					1279:1282	a human mesenchymal stem cell line	1249:1282	a human mesenchymal stem cell line	1249:1282	With application of this ink, cytocompatibility was proven in indirect cell culture and bioplotting experiments using a human mesenchymal stem cell line.
33507748	8	18	theme	mesenchymal	1257:1267	arg1	line					1279:1282	a human mesenchymal stem cell line	1249:1282	a human mesenchymal stem cell line	1249:1282	With application of this ink, cytocompatibility was proven in indirect cell culture and bioplotting experiments using a human mesenchymal stem cell line.
33507748	9	19	theme	scaffold	1509:1516	arg1	orientations					1518:1529	scaffold orientations	1509:1529	scaffold orientations	1509:1529	Toward the deformation of cell-laden scaffolds to support cell differentiation in the future, radiography allowed the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field.
33507748	4	20	dep	size	558:561	arg1	The					554:556	The	554:556	The	554:556	The size and shape of particles were monitored via scanning electron microscopy and X-ray micro-computed tomography.
33507748	9	21	theme	deformation	1448:1458	arg1	monitoring					1413:1422	the real-time monitoring	1399:1422	the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field	1399:1555	Toward the deformation of cell-laden scaffolds to support cell differentiation in the future, radiography allowed the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field.
33507748	10	22	theme	stimulatory	1658:1668	arg1	experiments					1670:1680	stimulatory experiments	1658:1680	stimulatory experiments	1658:1680	Varying the strand distance and scaffold design will allow fine-tuning the degree of deformation in stimulatory experiments.
33507748	8	23	theme	human	1251:1255	arg1	line					1279:1282	a human mesenchymal stem cell line	1249:1282	a human mesenchymal stem cell line	1249:1282	With application of this ink, cytocompatibility was proven in indirect cell culture and bioplotting experiments using a human mesenchymal stem cell line.
33507748	8	24	theme	cell	1202:1205	arg1	culture					1207:1213	indirect cell culture	1193:1213	indirect cell culture	1193:1213	With application of this ink, cytocompatibility was proven in indirect cell culture and bioplotting experiments using a human mesenchymal stem cell line.
33507748	10	25	theme	scaffold	1590:1597	arg1	design					1599:1604	scaffold design	1590:1604	scaffold design	1590:1604	Varying the strand distance and scaffold design will allow fine-tuning the degree of deformation in stimulatory experiments.
33507748	7	26	theme	%	1103:1103	arg1	magnetite					1109:1117	algMC + 25% w/w magnetite	1093:1117	algMC + 25% w/w magnetite	1093:1117	The printability and shape fidelity of various shapes were evaluated, so that the final composition of algMC + 25% w/w magnetite was chosen.
33507748	1	27	theme	tissue	204:209	arg1	development					211:221	tissue development	204:221	tissue development	204:221	Mechanical stimulation of cells embedded in scaffolds is known to increase the cellular performance toward osteogenic or chondrogenic differentiation and tissue development.
33507748	8	28	theme	indirect	1193:1200	arg1	culture					1207:1213	indirect cell culture	1193:1213	indirect cell culture	1193:1213	With application of this ink, cytocompatibility was proven in indirect cell culture and bioplotting experiments using a human mesenchymal stem cell line.
33507748	3	29	dep	methylcellulose	443:457	arg1	MC					460:461	MC	460:461	MC	460:461	In this study, a magnetic bioink based on alginate (alg, 3%) and methylcellulose (MC, 9%) with incorporated magnetite microparticles (25% w/w) was developed and characterized.
33507748	3	29	dep	methylcellulose	443:457	arg1	%					465:465	9%	464:465	9%	464:465	In this study, a magnetic bioink based on alginate (alg, 3%) and methylcellulose (MC, 9%) with incorporated magnetite microparticles (25% w/w) was developed and characterized.
33507748	8	30	theme	bioplotting	1219:1229	arg1	experiments					1231:1241	bioplotting experiments	1219:1241	bioplotting experiments using a human mesenchymal stem cell line	1219:1282	With application of this ink, cytocompatibility was proven in indirect cell culture and bioplotting experiments using a human mesenchymal stem cell line.
33507748	8	31	theme	stem	1269:1272	arg1	line					1279:1282	a human mesenchymal stem cell line	1249:1282	a human mesenchymal stem cell line	1249:1282	With application of this ink, cytocompatibility was proven in indirect cell culture and bioplotting experiments using a human mesenchymal stem cell line.
33507748	0	32	theme	Deformable	28:37	arg1	Scaffolds					39:47	Magnetically Deformable Scaffolds	15:47	Magnetically Deformable Scaffolds	15:47	Bioprinting of Magnetically Deformable Scaffolds.
33507748	9	33	theme	different	1476:1484	arg1	architectures					1491:1503	different pore architectures	1476:1503	different pore architectures	1476:1503	Toward the deformation of cell-laden scaffolds to support cell differentiation in the future, radiography allowed the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field.
33507748	9	34	theme	real-time	1403:1411	arg1	monitoring					1413:1422	the real-time monitoring	1399:1422	the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field	1399:1555	Toward the deformation of cell-laden scaffolds to support cell differentiation in the future, radiography allowed the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field.
33507748	4	35	theme	X-ray	638:642	arg1	tomography					659:668	X-ray micro-computed tomography	638:668	X-ray micro-computed tomography	638:668	The size and shape of particles were monitored via scanning electron microscopy and X-ray micro-computed tomography.
33507748	10	36	theme	deformation	1643:1653	arg1	degree					1633:1638	the degree	1629:1638	the degree of deformation	1629:1653	Varying the strand distance and scaffold design will allow fine-tuning the degree of deformation in stimulatory experiments.
33507748	2	37	theme	regions	369:375	arg1	distribution					321:332	the spatially defined distribution	299:332	the spatially defined distribution of magnetically inducible scaffold regions	299:375	Three-dimensional bioplotting of magnetically deformable scaffolds enables the spatially defined distribution of magnetically inducible scaffold regions.
33507748	3	38	theme	incorporated	473:484	arg1	microparticles					496:509	magnetite microparticles	486:509	incorporated magnetite microparticles (25% w/w)	473:519	In this study, a magnetic bioink based on alginate (alg, 3%) and methylcellulose (MC, 9%) with incorporated magnetite microparticles (25% w/w) was developed and characterized.
33507748	3	38	theme	incorporated	473:484	arg1	%					514:514	25% w/w	512:518	25% w/w	512:518	In this study, a magnetic bioink based on alginate (alg, 3%) and methylcellulose (MC, 9%) with incorporated magnetite microparticles (25% w/w) was developed and characterized.
33507748	0	39	theme	Scaffolds	39:47	arg1	Bioprinting					0:10	Bioprinting	0:10	Bioprinting of Magnetically Deformable Scaffolds	0:47	Bioprinting of Magnetically Deformable Scaffolds.
33507748	7	40	theme	algMC	1093:1097	arg1	magnetite					1109:1117	algMC + 25% w/w magnetite	1093:1117	algMC + 25% w/w magnetite	1093:1117	The printability and shape fidelity of various shapes were evaluated, so that the final composition of algMC + 25% w/w magnetite was chosen.
33507748	2	41	theme	scaffolds	281:289	arg1	bioplotting					242:252	Three-dimensional bioplotting	224:252	Three-dimensional bioplotting of magnetically deformable scaffolds	224:289	Three-dimensional bioplotting of magnetically deformable scaffolds enables the spatially defined distribution of magnetically inducible scaffold regions.
33507748	4	42	theme	micro-computed	644:657	arg1	tomography					659:668	X-ray micro-computed tomography	638:668	X-ray micro-computed tomography	638:668	The size and shape of particles were monitored via scanning electron microscopy and X-ray micro-computed tomography.
33507748	10	43	theme	strand	1570:1575	arg1	distance					1577:1584	the strand distance	1566:1584	the strand distance	1566:1584	Varying the strand distance and scaffold design will allow fine-tuning the degree of deformation in stimulatory experiments.
33507748	7	44	theme	final	1072:1076	arg1	composition					1078:1088	the final composition	1068:1088	the final composition of algMC + 25% w/w magnetite	1068:1117	The printability and shape fidelity of various shapes were evaluated, so that the final composition of algMC + 25% w/w magnetite was chosen.
33507748	5	45	theme	microparticles	790:803	arg1	concentrations					762:775	different concentrations	752:775	different concentrations of magnetite microparticles	752:803	Shear-thinning properties of the algMC ink were maintained after the addition of different concentrations of magnetite microparticles to the ink.
33507748	2	46	theme	deformable	270:279	arg1	scaffolds					281:289	magnetically deformable scaffolds	257:289	magnetically deformable scaffolds	257:289	Three-dimensional bioplotting of magnetically deformable scaffolds enables the spatially defined distribution of magnetically inducible scaffold regions.
33507748	9	47	theme	cell	1343:1346	arg1	differentiation					1348:1362	cell differentiation	1343:1362	cell differentiation	1343:1362	Toward the deformation of cell-laden scaffolds to support cell differentiation in the future, radiography allowed the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field.
33507748	9	48	theme	magnetic	1542:1549	arg1	field					1551:1555	the magnetic field	1538:1555	the magnetic field	1538:1555	Toward the deformation of cell-laden scaffolds to support cell differentiation in the future, radiography allowed the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field.
33507748	9	49	theme	scaffolds	1322:1330	arg1	deformation					1296:1306	the deformation	1292:1306	the deformation of cell-laden scaffolds to support cell differentiation in the future	1292:1376	Toward the deformation of cell-laden scaffolds to support cell differentiation in the future, radiography allowed the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field.
33507748	6	50	theme	sample	969:974	arg1	magnetometry					976:987	vibrating sample magnetometry	959:987	vibrating sample magnetometry	959:987	Its viscosity proportionally increased with the added amount of magnetite, and so did the level of saturation magnetization as determined via vibrating sample magnetometry.
33507748	5	51	theme	algMC	704:708	arg1	ink					710:712	the algMC ink	700:712	the algMC ink	700:712	Shear-thinning properties of the algMC ink were maintained after the addition of different concentrations of magnetite microparticles to the ink.
33507748	6	52	theme	magnetite	881:889	arg1	magnetite					881:889	magnetite	881:889	magnetite	881:889	Its viscosity proportionally increased with the added amount of magnetite, and so did the level of saturation magnetization as determined via vibrating sample magnetometry.
33507748	6	52	theme	magnetite	881:889	arg1	amount					871:876	the added amount	861:876	the added amount of magnetite	861:889	Its viscosity proportionally increased with the added amount of magnetite, and so did the level of saturation magnetization as determined via vibrating sample magnetometry.
33507748	3	53	theme	w/w	516:518	arg1	microparticles					496:509	magnetite microparticles	486:509	incorporated magnetite microparticles (25% w/w)	473:519	In this study, a magnetic bioink based on alginate (alg, 3%) and methylcellulose (MC, 9%) with incorporated magnetite microparticles (25% w/w) was developed and characterized.
33507748	3	53	theme	w/w	516:518	arg1	%					514:514	25% w/w	512:518	25% w/w	512:518	In this study, a magnetic bioink based on alginate (alg, 3%) and methylcellulose (MC, 9%) with incorporated magnetite microparticles (25% w/w) was developed and characterized.
33507748	6	54	theme	vibrating	959:967	arg1	magnetometry					976:987	vibrating sample magnetometry	959:987	vibrating sample magnetometry	959:987	Its viscosity proportionally increased with the added amount of magnetite, and so did the level of saturation magnetization as determined via vibrating sample magnetometry.
33507748	5	55	theme	ink	710:712	arg1	properties					686:695	Shear-thinning properties	671:695	Shear-thinning properties of the algMC ink	671:712	Shear-thinning properties of the algMC ink were maintained after the addition of different concentrations of magnetite microparticles to the ink.
33507748	3	56	theme	magnetite	486:494	arg1	microparticles					496:509	magnetite microparticles	486:509	incorporated magnetite microparticles (25% w/w)	473:519	In this study, a magnetic bioink based on alginate (alg, 3%) and methylcellulose (MC, 9%) with incorporated magnetite microparticles (25% w/w) was developed and characterized.
33507748	3	56	theme	magnetite	486:494	arg1	%					514:514	25% w/w	512:518	25% w/w	512:518	In this study, a magnetic bioink based on alginate (alg, 3%) and methylcellulose (MC, 9%) with incorporated magnetite microparticles (25% w/w) was developed and characterized.
33507748	7	57	dep	printability	994:1005	arg1	fidelity					1017:1024	fidelity	1017:1024	fidelity	1017:1024	The printability and shape fidelity of various shapes were evaluated, so that the final composition of algMC + 25% w/w magnetite was chosen.
33507748	7	57	dep	printability	994:1005	arg1	The					990:992	The	990:992	The	990:992	The printability and shape fidelity of various shapes were evaluated, so that the final composition of algMC + 25% w/w magnetite was chosen.
33507748	4	58	theme	scanning	605:612	arg1	microscopy					623:632	scanning electron microscopy	605:632	scanning electron microscopy	605:632	The size and shape of particles were monitored via scanning electron microscopy and X-ray micro-computed tomography.
33507748	3	59	dep	alginate	420:427	arg1	alg					430:432	alg	430:432	alg	430:432	In this study, a magnetic bioink based on alginate (alg, 3%) and methylcellulose (MC, 9%) with incorporated magnetite microparticles (25% w/w) was developed and characterized.
33507748	3	59	dep	alginate	420:427	arg1	%					436:436	3%	435:436	3%	435:436	In this study, a magnetic bioink based on alginate (alg, 3%) and methylcellulose (MC, 9%) with incorporated magnetite microparticles (25% w/w) was developed and characterized.
33507748	2	60	theme	Three-dimensional	224:240	arg1	bioplotting					242:252	Three-dimensional bioplotting	224:252	Three-dimensional bioplotting of magnetically deformable scaffolds	224:289	Three-dimensional bioplotting of magnetically deformable scaffolds enables the spatially defined distribution of magnetically inducible scaffold regions.
33507748	2	61	theme	defined	313:319	arg1	distribution					321:332	the spatially defined distribution	299:332	the spatially defined distribution of magnetically inducible scaffold regions	299:375	Three-dimensional bioplotting of magnetically deformable scaffolds enables the spatially defined distribution of magnetically inducible scaffold regions.
33507748	7	62	theme	various	1029:1035	arg1	shapes					1037:1042	various shapes	1029:1042	various shapes	1029:1042	The printability and shape fidelity of various shapes were evaluated, so that the final composition of algMC + 25% w/w magnetite was chosen.
33507748	9	63	theme	architectures	1491:1503	arg1	scaffolds					1463:1471	scaffolds	1463:1471	scaffolds of different pore architectures and scaffold orientations	1463:1529	Toward the deformation of cell-laden scaffolds to support cell differentiation in the future, radiography allowed the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field.
33507748	1	64	from	scaffolds	94:102	arg1	embedded					82:89	embedded	82:89	embedded	82:89	Mechanical stimulation of cells embedded in scaffolds is known to increase the cellular performance toward osteogenic or chondrogenic differentiation and tissue development.
33507748	1	65	theme	cellular	129:136	arg1	performance					138:148	the cellular performance	125:148	the cellular performance	125:148	Mechanical stimulation of cells embedded in scaffolds is known to increase the cellular performance toward osteogenic or chondrogenic differentiation and tissue development.
33507748	5	66	theme	magnetite	780:788	arg1	microparticles					790:803	magnetite microparticles	780:803	magnetite microparticles	780:803	Shear-thinning properties of the algMC ink were maintained after the addition of different concentrations of magnetite microparticles to the ink.
33507748	6	67	theme	added	865:869	arg1	magnetite					881:889	magnetite	881:889	magnetite	881:889	Its viscosity proportionally increased with the added amount of magnetite, and so did the level of saturation magnetization as determined via vibrating sample magnetometry.
33507748	6	67	theme	added	865:869	arg1	amount					871:876	the added amount	861:876	the added amount of magnetite	861:889	Its viscosity proportionally increased with the added amount of magnetite, and so did the level of saturation magnetization as determined via vibrating sample magnetometry.
33507748	1	68	theme	Mechanical	50:59	arg1	stimulation					61:71	Mechanical stimulation	50:71	Mechanical stimulation of cells embedded in scaffolds	50:102	Mechanical stimulation of cells embedded in scaffolds is known to increase the cellular performance toward osteogenic or chondrogenic differentiation and tissue development.
33507748	7	69	theme	shapes	1037:1042	arg1	printability					994:1005	printability	994:1005	printability	994:1005	The printability and shape fidelity of various shapes were evaluated, so that the final composition of algMC + 25% w/w magnetite was chosen.
33507748	7	69	theme	shapes	1037:1042	arg1	shape					1011:1015	shape	1011:1015	shape	1011:1015	The printability and shape fidelity of various shapes were evaluated, so that the final composition of algMC + 25% w/w magnetite was chosen.
33507748	9	70	theme	pore	1486:1489	arg1	architectures					1491:1503	different pore architectures	1476:1503	different pore architectures	1476:1503	Toward the deformation of cell-laden scaffolds to support cell differentiation in the future, radiography allowed the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field.
33507748	3	71	theme	magnetic	395:402	arg1	bioink					404:409	a magnetic bioink	393:409	a magnetic bioink based on alginate (alg, 3%) and methylcellulose (MC, 9%) with incorporated magnetite microparticles (25% w/w)	393:519	In this study, a magnetic bioink based on alginate (alg, 3%) and methylcellulose (MC, 9%) with incorporated magnetite microparticles (25% w/w) was developed and characterized.
33507748	9	72	theme	induced	1440:1446	arg1	deformation					1448:1458	magnetically induced deformation	1427:1458	magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations	1427:1529	Toward the deformation of cell-laden scaffolds to support cell differentiation in the future, radiography allowed the real-time monitoring of magnetically induced deformation of scaffolds of different pore architectures and scaffold orientations inside the magnetic field.
33507748	10	73	dep	Varying	1558:1564	arg1	allow					1611:1615	allow	1611:1615	Varying the strand distance and scaffold design will allow fine-tuning the degree of deformation in stimulatory experiments	1558:1680	Varying the strand distance and scaffold design will allow fine-tuning the degree of deformation in stimulatory experiments.
33507748	1	74	theme	osteogenic	157:166	arg1	differentiation					184:198	differentiation	184:198	differentiation	184:198	Mechanical stimulation of cells embedded in scaffolds is known to increase the cellular performance toward osteogenic or chondrogenic differentiation and tissue development.
33507748	1	75	from	embedded	82:89	arg1	scaffolds					94:102	scaffolds	94:102	scaffolds	94:102	Mechanical stimulation of cells embedded in scaffolds is known to increase the cellular performance toward osteogenic or chondrogenic differentiation and tissue development.
33507748	4	76	theme	electron	614:621	arg1	microscopy					623:632	scanning electron microscopy	605:632	scanning electron microscopy	605:632	The size and shape of particles were monitored via scanning electron microscopy and X-ray micro-computed tomography.
34171252	2	0	theme	structural	470:479	arg1	properties					496:505	physical, mechanical, structural and functional properties	448:505	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films	391:521	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films were investigated.
34171252	6	1	theme	antioxidant	929:939	arg1	capacity					941:948	The antioxidant capacity	925:948	The antioxidant capacity of composite films	925:967	The antioxidant capacity of composite films was related to the level of RE and demonstrated by the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay.
34171252	7	2	theme	Chilled	1092:1098	arg1	carp					1106:1109	Chilled grass carp	1092:1109	Chilled grass carp	1092:1109	Chilled grass carp fillets wrapped with different films to evaluate the preservative effect.
34171252	6	3	theme	free	1061:1064	arg1	scavenging					1074:1083	the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging	1020:1083	the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay	1020:1089	The antioxidant capacity of composite films was related to the level of RE and demonstrated by the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay.
34171252	9	4	theme	chain	1542:1546	arg1	transportation					1548:1561	food cold chain transportation	1532:1561	food cold chain transportation	1532:1561	The developed FMP/CS/RE composite films possess the potential to be applied as edible films in the food packaging industry and food cold chain transportation.
34171252	8	5	theme	basic	1282:1286	arg1	nitrogen					1288:1295	total volatile basic nitrogen	1267:1295	total volatile basic nitrogen	1267:1295	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	5	theme	basic	1282:1286	arg1	substances					1225:1234	thiobarbituric acid reactive substances	1196:1234	thiobarbituric acid reactive substances	1196:1234	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	7	6	theme	grass	1100:1104	arg1	carp					1106:1109	Chilled grass carp	1092:1109	Chilled grass carp	1092:1109	Chilled grass carp fillets wrapped with different films to evaluate the preservative effect.
34171252	8	7	theme	thiobarbituric	1196:1209	arg1	nitrogen					1288:1295	total volatile basic nitrogen	1267:1295	total volatile basic nitrogen	1267:1295	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	7	theme	thiobarbituric	1196:1209	arg1	acid					1258:1261	Free amino acid	1247:1261	Free amino acid	1247:1261	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	7	theme	thiobarbituric	1196:1209	arg1	substances					1225:1234	thiobarbituric acid reactive substances	1196:1234	thiobarbituric acid reactive substances	1196:1234	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	7	theme	thiobarbituric	1196:1209	arg1	value					1240:1244	pH value	1237:1244	pH value	1237:1244	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	4	8	theme	good	698:701	arg1	compatibility					703:715	good compatibility	698:715	good compatibility of the components	698:733	Results also showed good compatibility of the components and good dispersion of RE in the matrix.
34171252	9	9	contain	possess	1445:1451	arg1	films					1439:1443	The developed FMP/CS/RE composite films	1405:1443	The developed FMP/CS/RE composite films	1405:1443	The developed FMP/CS/RE composite films possess the potential to be applied as edible films in the food packaging industry and food cold chain transportation.
34171252	9	9	contain	possess	1445:1451	arg2	potential					1457:1465	the potential to be applied as edible films in the food packaging industry and food cold chain transportation	1453:1561	the potential to be applied as edible films in the food packaging industry and food cold chain transportation	1453:1561	The developed FMP/CS/RE composite films possess the potential to be applied as edible films in the food packaging industry and food cold chain transportation.
34171252	0	10	theme	improvement	119:129	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	0	10	theme	improvement	119:129	arg1	Development					0:10	Development	0:10	Development	0:10	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	9	11	theme	FMP/CS/RE	1419:1427	arg1	films					1439:1443	The developed FMP/CS/RE composite films	1405:1443	The developed FMP/CS/RE composite films	1405:1443	The developed FMP/CS/RE composite films possess the potential to be applied as edible films in the food packaging industry and food cold chain transportation.
34171252	8	12	theme	composite	1322:1330	arg1	film					1332:1335	FMP/CS/RE composite film	1312:1335	FMP/CS/RE composite film	1312:1335	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	6	13	theme	films	963:967	arg1	capacity					941:948	The antioxidant capacity	925:948	The antioxidant capacity of composite films	925:967	The antioxidant capacity of composite films was related to the level of RE and demonstrated by the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay.
34171252	2	14	theme	FMP/CS	510:515	arg1	films					517:521	FMP/CS films	510:521	FMP/CS films	510:521	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films were investigated.
34171252	9	15	theme	edible	1484:1489	arg1	films					1491:1495	edible films	1484:1495	edible films in the food packaging industry and food cold chain transportation	1484:1561	The developed FMP/CS/RE composite films possess the potential to be applied as edible films in the food packaging industry and food cold chain transportation.
34171252	8	16	theme	FMP/CS/RE	1312:1320	arg1	film					1332:1335	FMP/CS/RE composite film	1312:1335	FMP/CS/RE composite film	1312:1335	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	9	17	from	films	1491:1495	arg1	transportation					1548:1561	food cold chain transportation	1532:1561	food cold chain transportation	1532:1561	The developed FMP/CS/RE composite films possess the potential to be applied as edible films in the food packaging industry and food cold chain transportation.
34171252	9	17	from	films	1491:1495	arg1	industry					1519:1526	the food packaging industry	1500:1526	the food packaging industry	1500:1526	The developed FMP/CS/RE composite films possess the potential to be applied as edible films in the food packaging industry and food cold chain transportation.
34171252	7	18	dep	fillets	1111:1117	arg1	wrapped					1119:1125	wrapped	1119:1125	fillets wrapped with different films to evaluate the preservative effect	1111:1182	Chilled grass carp fillets wrapped with different films to evaluate the preservative effect.
34171252	6	19	theme	composite	953:961	arg1	films					963:967	composite films	953:967	composite films	953:967	The antioxidant capacity of composite films was related to the level of RE and demonstrated by the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay.
34171252	0	20	theme	lipid	134:138	arg1	oxidation					140:148	lipid oxidation	134:148	lipid oxidation	134:148	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	5	21	theme	film-forming	900:911	arg1	properties					913:922	their film-forming properties	894:922	their film-forming properties	894:922	However, the content of RE (0.2%, v/v) added in the composite films produced aggregations and had negative effects on their film-forming properties.
34171252	2	22	theme	different	406:414	arg1	concentrations					416:429	different concentrations	406:429	different concentrations of RE	406:435	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films were investigated.
34171252	8	23	theme	pH	1237:1238	arg1	substances					1225:1234	thiobarbituric acid reactive substances	1196:1234	thiobarbituric acid reactive substances	1196:1234	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	23	theme	pH	1237:1238	arg1	value					1240:1244	pH value	1237:1244	pH value	1237:1244	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	6	24	theme	2,2-diphenyl-1-picrylhydrazyl	1030:1058	arg1	scavenging					1074:1083	the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging	1020:1083	the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay	1020:1089	The antioxidant capacity of composite films was related to the level of RE and demonstrated by the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay.
34171252	7	25	theme	preservative	1164:1175	arg1	effect					1177:1182	the preservative effect	1160:1182	the preservative effect	1160:1182	Chilled grass carp fillets wrapped with different films to evaluate the preservative effect.
34171252	2	26	theme	mechanical	458:467	arg1	properties					496:505	physical, mechanical, structural and functional properties	448:505	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films	391:521	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films were investigated.
34171252	9	27	theme	food	1532:1535	arg1	transportation					1548:1561	food cold chain transportation	1532:1561	food cold chain transportation	1532:1561	The developed FMP/CS/RE composite films possess the potential to be applied as edible films in the food packaging industry and food cold chain transportation.
34171252	1	28	theme	Biofilm	199:205	arg1	composition					207:217	Biofilm composition	199:217	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE)	199:321	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE) was developed and applied to monitor the freshness of fish fillets.
34171252	2	29	theme	functional	485:494	arg1	properties					496:505	physical, mechanical, structural and functional properties	448:505	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films	391:521	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films were investigated.
34171252	9	30	theme	cold	1537:1540	arg1	transportation					1548:1561	food cold chain transportation	1532:1561	food cold chain transportation	1532:1561	The developed FMP/CS/RE composite films possess the potential to be applied as edible films in the food packaging industry and food cold chain transportation.
34171252	6	31	theme	DPPH	1024:1027	arg1	scavenging					1074:1083	the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging	1020:1083	the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay	1020:1089	The antioxidant capacity of composite films was related to the level of RE and demonstrated by the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay.
34171252	5	32	theme	RE	800:801	arg1	content					789:795	the content	785:795	the content of RE (0.2%, v/v) added in the composite films	785:842	However, the content of RE (0.2%, v/v) added in the composite films produced aggregations and had negative effects on their film-forming properties.
34171252	8	33	theme	substances	1225:1234	arg1	Results					1185:1191	Results	1185:1191	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen	1185:1295	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	3	34	theme	reduced	569:575	arg1	solubility					583:592	reduced water solubility	569:592	reduced water solubility	569:592	Films containing RE showed reduced water solubility and water vapor permeability and enhanced tensile strength and elongation at break.
34171252	5	35	theme	composite	828:836	arg1	films					838:842	the composite films	824:842	the composite films	824:842	However, the content of RE (0.2%, v/v) added in the composite films produced aggregations and had negative effects on their film-forming properties.
34171252	2	36	theme	RE	434:435	arg1	concentrations					416:429	different concentrations	406:429	different concentrations of RE	406:435	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films were investigated.
34171252	3	37	contain	containing	548:557	arg2	RE					559:560	RE	559:560	RE	559:560	Films containing RE showed reduced water solubility and water vapor permeability and enhanced tensile strength and elongation at break.
34171252	3	37	contain	containing	548:557	arg1	Films					542:546	Films	542:546	Films containing RE	542:560	Films containing RE showed reduced water solubility and water vapor permeability and enhanced tensile strength and elongation at break.
34171252	8	38	theme	total	1267:1271	arg1	nitrogen					1288:1295	total volatile basic nitrogen	1267:1295	total volatile basic nitrogen	1267:1295	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	38	theme	total	1267:1271	arg1	substances					1225:1234	thiobarbituric acid reactive substances	1196:1234	thiobarbituric acid reactive substances	1196:1234	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	9	39	theme	developed	1409:1417	arg1	films					1439:1443	The developed FMP/CS/RE composite films	1405:1443	The developed FMP/CS/RE composite films	1405:1443	The developed FMP/CS/RE composite films possess the potential to be applied as edible films in the food packaging industry and food cold chain transportation.
34171252	4	40	theme	RE	758:759	arg1	compatibility					703:715	good compatibility	698:715	good compatibility of the components	698:733	Results also showed good compatibility of the components and good dispersion of RE in the matrix.
34171252	4	40	theme	RE	758:759	arg1	dispersion					744:753	good dispersion	739:753	good dispersion of RE	739:759	Results also showed good compatibility of the components and good dispersion of RE in the matrix.
34171252	2	41	theme	concentrations	416:429	arg1	properties					496:505	physical, mechanical, structural and functional properties	448:505	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films	391:521	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films were investigated.
34171252	2	41	theme	concentrations	416:429	arg1	effects					395:401	The effects	391:401	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films	391:521	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films were investigated.
34171252	4	42	theme	good	739:742	arg1	dispersion					744:753	good dispersion	739:753	good dispersion of RE	739:759	Results also showed good compatibility of the components and good dispersion of RE in the matrix.
34171252	1	43	theme	rosemary	301:308	arg1	RE					319:320	RE	319:320	RE	319:320	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE) was developed and applied to monitor the freshness of fish fillets.
34171252	1	43	theme	rosemary	301:308	arg1	extract					310:316	rosemary extract	301:316	rosemary extract (RE)	301:321	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE) was developed and applied to monitor the freshness of fish fillets.
34171252	0	44	theme	oxidation	140:148	arg1	improvement					119:129	the improvement	115:129	the improvement of lipid oxidation	115:148	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	0	44	theme	oxidation	140:148	arg1	extract					80:86	fish myofibrillar protein/chitosan/rosemary extract	36:86	fish myofibrillar protein/chitosan/rosemary extract	36:86	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	1	45	theme	fish	377:380	arg1	fillets					382:388	fish fillets	377:388	fish fillets	377:388	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE) was developed and applied to monitor the freshness of fish fillets.
34171252	8	46	theme	fish	1355:1358	arg1	fillet					1360:1365	the fish fillet	1351:1365	the fish fillet	1351:1365	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	2	47	theme	physical	448:455	arg1	properties					496:505	physical, mechanical, structural and functional properties	448:505	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films	391:521	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films were investigated.
34171252	1	48	theme	myofibrillar	229:240	arg1	FMP					251:253	FMP	251:253	FMP	251:253	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE) was developed and applied to monitor the freshness of fish fillets.
34171252	1	48	theme	myofibrillar	229:240	arg1	protein					242:248	fish myofibrillar protein	224:248	fish myofibrillar protein (FMP)	224:254	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE) was developed and applied to monitor the freshness of fish fillets.
34171252	0	49	theme	myofibrillar	41:52	arg1	extract					80:86	fish myofibrillar protein/chitosan/rosemary extract	36:86	fish myofibrillar protein/chitosan/rosemary extract	36:86	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	1	50	from	solution	269:276	arg1	composition					207:217	Biofilm composition	199:217	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE)	199:321	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE) was developed and applied to monitor the freshness of fish fillets.
34171252	1	51	theme	fillets	382:388	arg1	freshness					364:372	the freshness	360:372	the freshness of fish fillets	360:388	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE) was developed and applied to monitor the freshness of fish fillets.
34171252	0	52	dep	extract	80:86	arg1	films					105:109	composite edible films	88:109	composite edible films	88:109	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	0	52	dep	extract	80:86	arg1	stability					150:158	stability	150:158	stability	150:158	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	8	53	theme	amino	1252:1256	arg1	acid					1258:1261	Free amino acid	1247:1261	Free amino acid	1247:1261	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	53	theme	amino	1252:1256	arg1	substances					1225:1234	thiobarbituric acid reactive substances	1196:1234	thiobarbituric acid reactive substances	1196:1234	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	0	54	theme	fish	36:39	arg1	extract					80:86	fish myofibrillar protein/chitosan/rosemary extract	36:86	fish myofibrillar protein/chitosan/rosemary extract	36:86	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	3	55	theme	water	598:602	arg1	permeability					610:621	water vapor permeability	598:621	water vapor permeability	598:621	Films containing RE showed reduced water solubility and water vapor permeability and enhanced tensile strength and elongation at break.
34171252	1	56	from	protein	242:248	arg1	composition					207:217	Biofilm composition	199:217	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE)	199:321	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE) was developed and applied to monitor the freshness of fish fillets.
34171252	6	57	theme	RE	997:998	arg1	level					988:992	the level	984:992	the level of RE	984:998	The antioxidant capacity of composite films was related to the level of RE and demonstrated by the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay.
34171252	0	58	theme	extract	80:86	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	0	58	theme	extract	80:86	arg1	Development					0:10	Development	0:10	Development	0:10	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	2	59	theme	films	517:521	arg1	properties					496:505	physical, mechanical, structural and functional properties	448:505	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films	391:521	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films were investigated.
34171252	2	59	theme	films	517:521	arg1	effects					395:401	The effects	391:401	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films	391:521	The effects of different concentrations of RE as well as physical, mechanical, structural and functional properties of FMP/CS films were investigated.
34171252	3	60	theme	water	577:581	arg1	solubility					583:592	reduced water solubility	569:592	reduced water solubility	569:592	Films containing RE showed reduced water solubility and water vapor permeability and enhanced tensile strength and elongation at break.
34171252	0	61	theme	protein/chitosan/rosemary	54:78	arg1	extract					80:86	fish myofibrillar protein/chitosan/rosemary extract	36:86	fish myofibrillar protein/chitosan/rosemary extract	36:86	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	9	62	theme	food	1504:1507	arg1	industry					1519:1526	the food packaging industry	1500:1526	the food packaging industry	1500:1526	The developed FMP/CS/RE composite films possess the potential to be applied as edible films in the food packaging industry and food cold chain transportation.
34171252	0	63	theme	grass	171:175	arg1	carp					177:180	the grass carp	167:180	the grass carp	167:180	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	9	64	theme	packaging	1509:1517	arg1	industry					1519:1526	the food packaging industry	1500:1526	the food packaging industry	1500:1526	The developed FMP/CS/RE composite films possess the potential to be applied as edible films in the food packaging industry and food cold chain transportation.
34171252	5	65	dep	%	807:807	arg1	v/v					810:812	v/v	810:812	v/v	810:812	However, the content of RE (0.2%, v/v) added in the composite films produced aggregations and had negative effects on their film-forming properties.
34171252	5	66	theme	negative	874:881	arg1	effects					883:889	negative effects	874:889	negative effects	874:889	However, the content of RE (0.2%, v/v) added in the composite films produced aggregations and had negative effects on their film-forming properties.
34171252	7	67	theme	different	1132:1140	arg1	films					1142:1146	different films	1132:1146	different films	1132:1146	Chilled grass carp fillets wrapped with different films to evaluate the preservative effect.
34171252	5	68	contain	had	870:872	arg1	content					789:795	the content	785:795	the content of RE (0.2%, v/v) added in the composite films	785:842	However, the content of RE (0.2%, v/v) added in the composite films produced aggregations and had negative effects on their film-forming properties.
34171252	5	68	contain	had	870:872	arg2	effects					883:889	negative effects	874:889	negative effects	874:889	However, the content of RE (0.2%, v/v) added in the composite films produced aggregations and had negative effects on their film-forming properties.
34171252	8	69	theme	volatile	1273:1280	arg1	nitrogen					1288:1295	total volatile basic nitrogen	1267:1295	total volatile basic nitrogen	1267:1295	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	69	theme	volatile	1273:1280	arg1	substances					1225:1234	thiobarbituric acid reactive substances	1196:1234	thiobarbituric acid reactive substances	1196:1234	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	3	70	dep	tensile	636:642	arg1	strength					644:651	strength	644:651	strength	644:651	Films containing RE showed reduced water solubility and water vapor permeability and enhanced tensile strength and elongation at break.
34171252	8	71	theme	lipid	1388:1392	arg1	oxidation					1394:1402	the lipid oxidation	1384:1402	the lipid oxidation	1384:1402	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	4	72	theme	components	724:733	arg1	compatibility					703:715	good compatibility	698:715	good compatibility of the components	698:733	Results also showed good compatibility of the components and good dispersion of RE in the matrix.
34171252	4	72	theme	components	724:733	arg1	dispersion					744:753	good dispersion	739:753	good dispersion of RE	739:759	Results also showed good compatibility of the components and good dispersion of RE in the matrix.
34171252	8	73	theme	acid	1211:1214	arg1	nitrogen					1288:1295	total volatile basic nitrogen	1267:1295	total volatile basic nitrogen	1267:1295	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	73	theme	acid	1211:1214	arg1	acid					1258:1261	Free amino acid	1247:1261	Free amino acid	1247:1261	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	73	theme	acid	1211:1214	arg1	substances					1225:1234	thiobarbituric acid reactive substances	1196:1234	thiobarbituric acid reactive substances	1196:1234	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	73	theme	acid	1211:1214	arg1	value					1240:1244	pH value	1237:1244	pH value	1237:1244	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	0	74	theme	edible	98:103	arg1	films					105:109	composite edible films	88:109	composite edible films	88:109	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	8	75	theme	Free	1247:1250	arg1	acid					1258:1261	Free amino acid	1247:1261	Free amino acid	1247:1261	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	75	theme	Free	1247:1250	arg1	substances					1225:1234	thiobarbituric acid reactive substances	1196:1234	thiobarbituric acid reactive substances	1196:1234	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	3	76	theme	vapor	604:608	arg1	permeability					610:621	water vapor permeability	598:621	water vapor permeability	598:621	Films containing RE showed reduced water solubility and water vapor permeability and enhanced tensile strength and elongation at break.
34171252	1	77	theme	fish	224:227	arg1	FMP					251:253	FMP	251:253	FMP	251:253	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE) was developed and applied to monitor the freshness of fish fillets.
34171252	1	77	theme	fish	224:227	arg1	protein					242:248	fish myofibrillar protein	224:248	fish myofibrillar protein (FMP)	224:254	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE) was developed and applied to monitor the freshness of fish fillets.
34171252	6	78	theme	scavenging	1074:1083	arg1	assay					1085:1089	the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay	1020:1089	the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay	1020:1089	The antioxidant capacity of composite films was related to the level of RE and demonstrated by the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay.
34171252	8	79	theme	reactive	1216:1223	arg1	nitrogen					1288:1295	total volatile basic nitrogen	1267:1295	total volatile basic nitrogen	1267:1295	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	79	theme	reactive	1216:1223	arg1	acid					1258:1261	Free amino acid	1247:1261	Free amino acid	1247:1261	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	79	theme	reactive	1216:1223	arg1	substances					1225:1234	thiobarbituric acid reactive substances	1196:1234	thiobarbituric acid reactive substances	1196:1234	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	8	79	theme	reactive	1216:1223	arg1	value					1240:1244	pH value	1237:1244	pH value	1237:1244	Results of thiobarbituric acid reactive substances, pH value, Free amino acid and total volatile basic nitrogen indicated that FMP/CS/RE composite film could protect the fish fillet well and inhibit the lipid oxidation.
34171252	0	80	theme	composite	88:96	arg1	films					105:109	composite edible films	88:109	composite edible films	88:109	Development and characterization of fish myofibrillar protein/chitosan/rosemary extract composite edible films and the improvement of lipid oxidation stability during the grass carp fillets storage.
34171252	9	81	theme	composite	1429:1437	arg1	films					1439:1443	The developed FMP/CS/RE composite films	1405:1443	The developed FMP/CS/RE composite films	1405:1443	The developed FMP/CS/RE composite films possess the potential to be applied as edible films in the food packaging industry and food cold chain transportation.
34171252	6	82	theme	radical	1066:1072	arg1	scavenging					1074:1083	the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging	1020:1083	the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay	1020:1089	The antioxidant capacity of composite films was related to the level of RE and demonstrated by the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay.
34171252	1	83	theme	chitosan	260:267	arg1	CS					279:280	CS	279:280	CS	279:280	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE) was developed and applied to monitor the freshness of fish fillets.
34171252	1	83	theme	chitosan	260:267	arg1	solution					269:276	chitosan solution	260:276	chitosan solution (CS)	260:281	Biofilm composition from fish myofibrillar protein (FMP) and chitosan solution (CS) incorporated with rosemary extract (RE) was developed and applied to monitor the freshness of fish fillets.
34254865	1	0	theme	gastric	410:416	arg1	conditions					418:427	postprandial gastric conditions	397:427	postprandial gastric conditions	397:427	OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, a system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions.
34254865	10	1	theme	in	1606:1607	arg1	events					1614:1619	in vivo events	1606:1619	in vivo events	1606:1619	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	4	2	theme	sodium	718:723	arg1	alginate					725:732	sodium alginate	718:732	sodium alginate	718:732	METHODS Dispersions of sodium alginate, calcium carbonate, and sodium bicarbonate were prepared with levels similar to commercial formulations.
34254865	10	3	theme	strong	1627:1632	arg1	effect					1641:1646	a strong matrix effect	1625:1646	a strong matrix effect	1625:1646	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	10	4	dep	CONCLUSIONS	1491:1501	arg1	testing					1512:1518	In vitro testing	1503:1518	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH	1491:1570	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	1	5	theme	raft-forming	197:208	arg1	alginates					210:218	raft-forming alginates	197:218	raft-forming alginates	197:218	OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, a system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions.
34254865	2	6	theme	raft-forming	510:521	arg1	alginates					523:531	raft-forming alginates	510:531	raft-forming alginates	510:531	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates may aid in formulation optimization.
34254865	10	7	theme	forming	1528:1534	arg1	alginates					1536:1544	raft forming alginates	1523:1544	raft forming alginates in HCl solution at low pH	1523:1570	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	0	8	theme	postprandial	138:149	arg1	conditions					151:160	gastric postprandial conditions	130:160	gastric postprandial conditions	130:160	Characterization of raft-forming alginate suspensions formed in HCl or model food systems at varying pH levels to better simulate gastric postprandial conditions.
34254865	1	9	theme	accurate	370:377	arg1	representation					379:392	a more accurate representation	363:392	a more accurate representation of postprandial gastric conditions	363:427	OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, a system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions.
34254865	5	10	theme	protein-rich	893:904	arg1	beverage					906:913	a protein-rich beverage	891:913	a protein-rich beverage at pH 1-4 to assess raft properties	891:949	Rafts were formed in HCl solution, tomato soup, and a protein-rich beverage at pH 1-4 to assess raft properties.
34254865	2	11	theme	system	479:484	arg1	impact					460:465	the impact	456:465	the impact of the food system and pH on properties of raft-forming alginates	456:531	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates may aid in formulation optimization.
34254865	7	12	theme	tomato	1161:1166	arg1	48.5 ± 9.8 g					1174:1185	48.5 ± 9.8 g	1174:1185	48.5 ± 9.8 g	1174:1185	The highest mass was obtained in tomato soup (48.5 ± 9.8 g) compared to the protein-rich beverage and HCl solution (32.5 ± 4.5 g and 23.4 ± 4.8 g, respectively) at pH 1.
34254865	7	12	theme	tomato	1161:1166	arg1	soup					1168:1171	tomato soup	1161:1171	tomato soup (48.5 ± 9.8 g) compared to the protein-rich beverage	1161:1224	The highest mass was obtained in tomato soup (48.5 ± 9.8 g) compared to the protein-rich beverage and HCl solution (32.5 ± 4.5 g and 23.4 ± 4.8 g, respectively) at pH 1.
34254865	10	13	theme	model	1687:1691	arg1	systems					1698:1704	model meal systems	1687:1704	model meal systems	1687:1704	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	0	14	theme	food	77:80	arg1	systems					82:88	model food systems	71:88	model food systems	71:88	Characterization of raft-forming alginate suspensions formed in HCl or model food systems at varying pH levels to better simulate gastric postprandial conditions.
34254865	1	15	theme	protein-rich	321:332	arg1	beverage					334:341	protein-rich beverage	321:341	HCl solution; tomato soup; protein-rich beverage	294:341	OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, a system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions.
34254865	6	16	theme	Significant	960:970	arg1	p < 0.05					985:992	p < 0.05	985:992	p < 0.05	985:992	RESULTS Significant differences (p < 0.05) in raft mass, strength, resilience, and ability to buffer acid were observed depending on the system in which the rafts were formed.
34254865	6	16	theme	Significant	960:970	arg1	differences					972:982	Significant differences	960:982	Significant differences (p < 0.05) in raft mass, strength, resilience, and ability to buffer acid	960:1056	RESULTS Significant differences (p < 0.05) in raft mass, strength, resilience, and ability to buffer acid were observed depending on the system in which the rafts were formed.
34254865	4	17	theme	carbonate	743:751	arg1	Dispersions					703:713	METHODS Dispersions	695:713	METHODS Dispersions of sodium alginate, calcium carbonate, and sodium bicarbonate	695:775	METHODS Dispersions of sodium alginate, calcium carbonate, and sodium bicarbonate were prepared with levels similar to commercial formulations.
34254865	2	18	theme	pH	490:491	arg1	impact					460:465	the impact	456:465	the impact of the food system and pH on properties of raft-forming alginates	456:531	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates may aid in formulation optimization.
34254865	2	19	from	Knowledge	443:451	arg1	properties					496:505	properties	496:505	properties of raft-forming alginates	496:531	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates may aid in formulation optimization.
34254865	0	20	theme	pH	101:102	arg1	levels					104:109	varying pH levels	93:109	varying pH levels	93:109	Characterization of raft-forming alginate suspensions formed in HCl or model food systems at varying pH levels to better simulate gastric postprandial conditions.
34254865	2	21	theme	SIGNIFICANCE	430:441	arg1	Knowledge					443:451	SIGNIFICANCE Knowledge	430:451	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates	430:531	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates may aid in formulation optimization.
34254865	1	22	dep	solution	298:305	arg1	soup					315:318	tomato soup	308:318	HCl solution; tomato soup; protein-rich beverage	294:341	OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, a system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions.
34254865	1	22	dep	solution	298:305	arg1	beverage					334:341	protein-rich beverage	321:341	HCl solution; tomato soup; protein-rich beverage	294:341	OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, a system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions.
34254865	6	23	from	differences	972:982	arg1	resilience					1019:1028	resilience	1019:1028	resilience	1019:1028	RESULTS Significant differences (p < 0.05) in raft mass, strength, resilience, and ability to buffer acid were observed depending on the system in which the rafts were formed.
34254865	6	23	from	differences	972:982	arg1	ability					1035:1041	ability	1035:1041	ability to buffer acid	1035:1056	RESULTS Significant differences (p < 0.05) in raft mass, strength, resilience, and ability to buffer acid were observed depending on the system in which the rafts were formed.
34254865	6	23	from	differences	972:982	arg1	strength					1009:1016	strength	1009:1016	strength	1009:1016	RESULTS Significant differences (p < 0.05) in raft mass, strength, resilience, and ability to buffer acid were observed depending on the system in which the rafts were formed.
34254865	6	23	from	differences	972:982	arg1	mass					1003:1006	raft mass	998:1006	raft mass	998:1006	RESULTS Significant differences (p < 0.05) in raft mass, strength, resilience, and ability to buffer acid were observed depending on the system in which the rafts were formed.
34254865	9	24	dep	added	1438:1442	arg1	buffer					1431:1436	buffer	1431:1436	buffer	1431:1436	Rafts formed in both food systems had a greater ability to buffer added acid compared to rafts formed in HCl solution.
34254865	10	25	theme	HCl	1549:1551	arg1	solution					1553:1560	HCl solution	1549:1560	HCl solution at low pH	1549:1570	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	9	26	theme	HCl	1477:1479	arg1	solution					1481:1488	HCl solution	1477:1488	HCl solution	1477:1488	Rafts formed in both food systems had a greater ability to buffer added acid compared to rafts formed in HCl solution.
34254865	0	27	theme	raft-forming	20:31	arg1	suspensions					42:52	raft-forming alginate suspensions	20:52	raft-forming alginate suspensions	20:52	Characterization of raft-forming alginate suspensions formed in HCl or model food systems at varying pH levels to better simulate gastric postprandial conditions.
34254865	2	28	theme	impact	460:465	arg1	Knowledge					443:451	SIGNIFICANCE Knowledge	430:451	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates	430:531	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates may aid in formulation optimization.
34254865	10	29	theme	pH	1737:1738	arg1	levels					1740:1745	representative postprandial pH levels	1709:1745	representative postprandial pH levels	1709:1745	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	0	30	theme	suspensions	42:52	arg1	Characterization					0:15	Characterization	0:15	Characterization of raft-forming alginate suspensions	0:52	Characterization of raft-forming alginate suspensions formed in HCl or model food systems at varying pH levels to better simulate gastric postprandial conditions.
34254865	1	31	theme	HCl	294:296	arg1	solution					298:305	HCl solution	294:305	HCl solution; tomato soup; protein-rich beverage	294:341	OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, a system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions.
34254865	6	32	theme	raft	998:1001	arg1	mass					1003:1006	raft mass	998:1006	raft mass	998:1006	RESULTS Significant differences (p < 0.05) in raft mass, strength, resilience, and ability to buffer acid were observed depending on the system in which the rafts were formed.
34254865	10	33	theme	representative	1709:1722	arg1	levels					1740:1745	representative postprandial pH levels	1709:1745	representative postprandial pH levels	1709:1745	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	8	34	theme	protein-rich	1318:1329	arg1	beverage					1331:1338	the protein-rich beverage	1314:1338	the protein-rich beverage	1314:1338	Rafts formed in the protein-rich beverage exhibited the highest strength.
34254865	1	35	dep	formed	286:291	arg1	solution					298:305	HCl solution	294:305	HCl solution; tomato soup; protein-rich beverage	294:341	OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, a system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions.
34254865	7	36	theme	protein-rich	1204:1215	arg1	beverage					1217:1224	the protein-rich beverage	1200:1224	the protein-rich beverage	1200:1224	The highest mass was obtained in tomato soup (48.5 ± 9.8 g) compared to the protein-rich beverage and HCl solution (32.5 ± 4.5 g and 23.4 ± 4.8 g, respectively) at pH 1.
34254865	4	37	theme	bicarbonate	765:775	arg1	Dispersions					703:713	METHODS Dispersions	695:713	METHODS Dispersions of sodium alginate, calcium carbonate, and sodium bicarbonate	695:775	METHODS Dispersions of sodium alginate, calcium carbonate, and sodium bicarbonate were prepared with levels similar to commercial formulations.
34254865	10	38	from	pH	1569:1570	arg1	solution					1553:1560	HCl solution	1549:1560	HCl solution at low pH	1549:1570	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	10	38	from	pH	1569:1570	arg1	alginates					1536:1544	raft forming alginates	1523:1544	raft forming alginates in HCl solution at low pH	1523:1570	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	8	39	theme	highest	1354:1360	arg1	strength					1362:1369	the highest strength	1350:1369	the highest strength	1350:1369	Rafts formed in the protein-rich beverage exhibited the highest strength.
34254865	7	40	dep	solution	1234:1241	arg1	32.5 ± 4.5 g					1244:1255	32.5 ± 4.5 g	1244:1255	32.5 ± 4.5 g	1244:1255	The highest mass was obtained in tomato soup (48.5 ± 9.8 g) compared to the protein-rich beverage and HCl solution (32.5 ± 4.5 g and 23.4 ± 4.8 g, respectively) at pH 1.
34254865	7	40	dep	solution	1234:1241	arg1	23.4 ± 4.8 g					1261:1272	23.4 ± 4.8 g	1261:1272	23.4 ± 4.8 g	1261:1272	The highest mass was obtained in tomato soup (48.5 ± 9.8 g) compared to the protein-rich beverage and HCl solution (32.5 ± 4.5 g and 23.4 ± 4.8 g, respectively) at pH 1.
34254865	6	41	theme	buffer	1046:1051	arg1	acid					1053:1056	buffer acid	1046:1056	buffer acid	1046:1056	RESULTS Significant differences (p < 0.05) in raft mass, strength, resilience, and ability to buffer acid were observed depending on the system in which the rafts were formed.
34254865	3	42	theme	therapeutic	676:686	arg1	efficacy					662:669	efficacy	662:669	efficacy	662:669	Recommendations may be made on food that is consumed prior to their consumption to optimize efficacy as a therapeutic agent.
34254865	3	42	theme	therapeutic	676:686	arg1	agent					688:692	a therapeutic agent	674:692	a therapeutic agent	674:692	Recommendations may be made on food that is consumed prior to their consumption to optimize efficacy as a therapeutic agent.
34254865	10	43	from	testing	1512:1518	arg1	solution					1553:1560	HCl solution	1549:1560	HCl solution at low pH	1549:1570	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	1	44	theme	conditions	418:427	arg1	representation					379:392	a more accurate representation	363:392	a more accurate representation of postprandial gastric conditions	363:427	OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, a system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions.
34254865	10	45	theme	matrix	1634:1639	arg1	effect					1641:1646	a strong matrix effect	1625:1646	a strong matrix effect	1625:1646	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	9	46	theme	added	1438:1442	arg1	acid					1444:1447	buffer added acid	1431:1447	buffer added acid	1431:1447	Rafts formed in both food systems had a greater ability to buffer added acid compared to rafts formed in HCl solution.
34254865	10	47	dep	In	1503:1504	arg1	vitro					1506:1510	vitro	1506:1510	vitro	1506:1510	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	10	48	from	alginates	1536:1544	arg1	solution					1553:1560	HCl solution	1549:1560	HCl solution at low pH	1549:1570	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	10	48	from	alginates	1536:1544	arg1	pH					1569:1570	low pH	1565:1570	low pH	1565:1570	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	4	49	theme	commercial	814:823	arg1	formulations					825:836	commercial formulations	814:836	commercial formulations	814:836	METHODS Dispersions of sodium alginate, calcium carbonate, and sodium bicarbonate were prepared with levels similar to commercial formulations.
34254865	10	50	theme	In	1503:1504	arg1	testing					1512:1518	In vitro testing	1503:1518	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH	1491:1570	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	1	51	theme	alginates	210:218	arg1	properties					183:192	properties	183:192	properties of raft-forming alginates	183:218	OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, a system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions.
34254865	2	52	theme	alginates	523:531	arg1	properties					496:505	properties	496:505	properties of raft-forming alginates	496:531	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates may aid in formulation optimization.
34254865	10	53	theme	alginates	1536:1544	arg1	testing					1512:1518	In vitro testing	1503:1518	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH	1491:1570	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	0	54	theme	gastric	130:136	arg1	conditions					151:160	gastric postprandial conditions	130:160	gastric postprandial conditions	130:160	Characterization of raft-forming alginate suspensions formed in HCl or model food systems at varying pH levels to better simulate gastric postprandial conditions.
34254865	5	55	theme	HCl	860:862	arg1	solution					864:871	HCl solution	860:871	HCl solution	860:871	Rafts were formed in HCl solution, tomato soup, and a protein-rich beverage at pH 1-4 to assess raft properties.
34254865	9	56	theme	food	1393:1396	arg1	systems					1398:1404	both food systems	1388:1404	both food systems	1388:1404	Rafts formed in both food systems had a greater ability to buffer added acid compared to rafts formed in HCl solution.
34254865	10	57	theme	raft	1523:1526	arg1	alginates					1536:1544	raft forming alginates	1523:1544	raft forming alginates in HCl solution at low pH	1523:1570	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	7	58	theme	highest	1132:1138	arg1	mass					1140:1143	The highest mass	1128:1143	The highest mass	1128:1143	The highest mass was obtained in tomato soup (48.5 ± 9.8 g) compared to the protein-rich beverage and HCl solution (32.5 ± 4.5 g and 23.4 ± 4.8 g, respectively) at pH 1.
34254865	2	59	theme	formulation	544:554	arg1	optimization					556:567	formulation optimization	544:567	formulation optimization	544:567	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates may aid in formulation optimization.
34254865	9	60	theme	greater	1412:1418	arg1	ability					1420:1426	a greater ability	1410:1426	a greater ability to buffer added acid	1410:1447	Rafts formed in both food systems had a greater ability to buffer added acid compared to rafts formed in HCl solution.
34254865	2	61	from	properties	496:505	arg1	Knowledge					443:451	SIGNIFICANCE Knowledge	430:451	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates	430:531	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates may aid in formulation optimization.
34254865	4	62	theme	METHODS	695:701	arg1	Dispersions					703:713	METHODS Dispersions	695:713	METHODS Dispersions of sodium alginate, calcium carbonate, and sodium bicarbonate	695:775	METHODS Dispersions of sodium alginate, calcium carbonate, and sodium bicarbonate were prepared with levels similar to commercial formulations.
34254865	0	63	theme	model	71:75	arg1	systems					82:88	model food systems	71:88	model food systems	71:88	Characterization of raft-forming alginate suspensions formed in HCl or model food systems at varying pH levels to better simulate gastric postprandial conditions.
34254865	1	64	theme	postprandial	397:408	arg1	conditions					418:427	postprandial gastric conditions	397:427	postprandial gastric conditions	397:427	OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, a system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions.
34254865	10	65	theme	meal	1693:1696	arg1	systems					1698:1704	model meal systems	1687:1704	model meal systems	1687:1704	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	2	66	theme	food	474:477	arg1	system					479:484	the food system	470:484	the food system	470:484	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates may aid in formulation optimization.
34254865	6	67	dep	RESULTS	952:958	arg1	observed					1063:1070	observed	1063:1070	were observed depending on the system in which the rafts were formed	1058:1125	RESULTS Significant differences (p < 0.05) in raft mass, strength, resilience, and ability to buffer acid were observed depending on the system in which the rafts were formed.
34254865	5	68	theme	tomato	874:879	arg1	soup					881:884	tomato soup	874:884	tomato soup	874:884	Rafts were formed in HCl solution, tomato soup, and a protein-rich beverage at pH 1-4 to assess raft properties.
34254865	0	69	theme	varying	93:99	arg1	levels					104:109	varying pH levels	93:109	varying pH levels	93:109	Characterization of raft-forming alginate suspensions formed in HCl or model food systems at varying pH levels to better simulate gastric postprandial conditions.
34254865	10	70	dep	in	1606:1607	arg1	vivo					1609:1612	vivo	1609:1612	vivo	1609:1612	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	4	71	theme	calcium	735:741	arg1	carbonate					743:751	calcium carbonate	735:751	calcium carbonate	735:751	METHODS Dispersions of sodium alginate, calcium carbonate, and sodium bicarbonate were prepared with levels similar to commercial formulations.
34254865	5	72	theme	raft	935:938	arg1	properties					940:949	raft properties	935:949	raft properties	935:949	Rafts were formed in HCl solution, tomato soup, and a protein-rich beverage at pH 1-4 to assess raft properties.
34254865	2	73	from	impact	460:465	arg1	properties					496:505	properties	496:505	properties of raft-forming alginates	496:531	SIGNIFICANCE Knowledge of the impact of the food system and pH on properties of raft-forming alginates may aid in formulation optimization.
34254865	1	74	theme	pH	349:350	arg1	levels					352:357	pH levels	349:357	pH levels	349:357	OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, a system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions.
34254865	0	75	theme	alginate	33:40	arg1	suspensions					42:52	raft-forming alginate suspensions	20:52	raft-forming alginate suspensions	20:52	Characterization of raft-forming alginate suspensions formed in HCl or model food systems at varying pH levels to better simulate gastric postprandial conditions.
34254865	7	76	theme	HCl	1230:1232	arg1	solution					1234:1241	HCl solution	1230:1241	HCl solution (32.5 ± 4.5 g and 23.4 ± 4.8 g, respectively)	1230:1287	The highest mass was obtained in tomato soup (48.5 ± 9.8 g) compared to the protein-rich beverage and HCl solution (32.5 ± 4.5 g and 23.4 ± 4.8 g, respectively) at pH 1.
34254865	4	77	theme	alginate	725:732	arg1	Dispersions					703:713	METHODS Dispersions	695:713	METHODS Dispersions of sodium alginate, calcium carbonate, and sodium bicarbonate	695:775	METHODS Dispersions of sodium alginate, calcium carbonate, and sodium bicarbonate were prepared with levels similar to commercial formulations.
34254865	9	78	contain	had	1406:1408	arg1	Rafts					1372:1376	Rafts	1372:1376	Rafts formed in both food systems	1372:1404	Rafts formed in both food systems had a greater ability to buffer added acid compared to rafts formed in HCl solution.
34254865	9	78	contain	had	1406:1408	arg2	ability					1420:1426	a greater ability	1410:1426	a greater ability to buffer added acid	1410:1447	Rafts formed in both food systems had a greater ability to buffer added acid compared to rafts formed in HCl solution.
34254865	10	79	theme	postprandial	1724:1735	arg1	levels					1740:1745	representative postprandial pH levels	1709:1745	representative postprandial pH levels	1709:1745	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	10	80	theme	low	1565:1567	arg1	pH					1569:1570	low pH	1565:1570	low pH	1565:1570	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	4	81	theme	similar	803:809	arg1	levels					796:801	levels	796:801	levels similar to commercial formulations	796:836	METHODS Dispersions of sodium alginate, calcium carbonate, and sodium bicarbonate were prepared with levels similar to commercial formulations.
34254865	5	82	from	pH	918:919	arg1	solution					864:871	HCl solution	860:871	HCl solution	860:871	Rafts were formed in HCl solution, tomato soup, and a protein-rich beverage at pH 1-4 to assess raft properties.
34254865	5	82	from	pH	918:919	arg1	soup					881:884	tomato soup	874:884	tomato soup	874:884	Rafts were formed in HCl solution, tomato soup, and a protein-rich beverage at pH 1-4 to assess raft properties.
34254865	5	82	from	pH	918:919	arg1	beverage					906:913	a protein-rich beverage	891:913	a protein-rich beverage at pH 1-4 to assess raft properties	891:949	Rafts were formed in HCl solution, tomato soup, and a protein-rich beverage at pH 1-4 to assess raft properties.
34254865	1	83	theme	tomato	308:313	arg1	soup					315:318	tomato soup	308:318	HCl solution; tomato soup; protein-rich beverage	294:341	OBJECTIVE Elucidate properties of raft-forming alginates in vitro with varying composition, a system in which the raft was formed (HCl solution; tomato soup; protein-rich beverage), and pH levels for a more accurate representation of postprandial gastric conditions.
34254865	10	84	from	solution	1553:1560	arg1	testing					1512:1518	In vitro testing	1503:1518	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH	1491:1570	CONCLUSIONS In vitro testing of raft forming alginates in HCl solution at low pH may not be sufficient to describe in vivo events, as a strong matrix effect was observed when rafts were formed in model meal systems at representative postprandial pH levels.
34254865	4	85	theme	sodium	758:763	arg1	bicarbonate					765:775	sodium bicarbonate	758:775	sodium bicarbonate	758:775	METHODS Dispersions of sodium alginate, calcium carbonate, and sodium bicarbonate were prepared with levels similar to commercial formulations.
32248158	8	0	theme	polyfunctional	1370:1383	arg1	%					1412:1412	the polyfunctional infusion solution HAES-LX-5%	1366:1412	the polyfunctional infusion solution HAES-LX-5%	1366:1412	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	3	1	theme	%	446:446	arg1	NaCl					416:419	isosmolar 0.9% NaCl	401:419	isosmolar 0.9% NaCl	401:419	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	3	1	theme	%	446:446	arg1	mannitol					435:442	hyperosmolar mannitol	422:442	hyperosmolar mannitol 15%	422:446	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	6	2	theme	volume	798:803	arg1	velocity					805:812	specific volume velocity	789:812	specific volume velocity of blood flow per 100 grams of brain substance	789:859	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	8	3	theme	solution	1394:1401	arg1	%					1412:1412	the polyfunctional infusion solution HAES-LX-5%	1366:1412	the polyfunctional infusion solution HAES-LX-5%	1366:1412	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	8	4	theme	0.9	1454:1456	arg1	%					1457:1457	%	1457:1457	%	1457:1457	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	1	5	with	patients	255:262	arg1	AIS					269:271	AIS	269:271	AIS	269:271	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
32248158	6	6	theme	treatment	998:1006	arg1	days					990:993	7 days	988:993	7 days of treatment	988:1006	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	1	7	from	hemodynamics	239:250	arg1	patients					255:262	patients	255:262	patients with AIS	255:271	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
32248158	8	8	theme	NaCl+mannitol	1459:1471	arg1	NaCl+mannitol					1459:1471	0.9% NaCl+mannitol	1454:1471	0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain	1454:1579	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	8	8	theme	NaCl+mannitol	1459:1471	arg1	group					1445:1449	group	1445:1449	group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain	1445:1579	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	8	8	theme	NaCl+mannitol	1459:1471	arg1	group					1435:1439	the 0.9% NaCl group	1421:1439	the 0.9% NaCl group	1421:1439	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	1	9	theme	%	182:182	arg1	NaCl					184:187	0.9% NaCl	179:187	0.9% NaCl	179:187	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
32248158	6	10	theme	substance	851:859	arg1	grams					836:840	100 grams	832:840	100 grams of brain substance	832:859	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	5	11	dep	hemodynamic	650:660	arg1	indexes					663:669	indexes	663:669	indexes of cerebral blood flow	663:692	Evaluation of cerebral hemodynamic (indexes of cerebral blood flow) was performed using doppler ultrasound of cerebral arteries.
32248158	0	12	from	hemodynamics	81:92	arg1	patients					97:104	patients	97:104	patients with acute ischemic stroke	97:131	Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke.
32248158	5	13	theme	arteries	746:753	arg1	ultrasound					723:732	doppler ultrasound	715:732	doppler ultrasound of cerebral arteries	715:753	Evaluation of cerebral hemodynamic (indexes of cerebral blood flow) was performed using doppler ultrasound of cerebral arteries.
32248158	4	14	theme	NaCl+mannitol	608:620	arg1	%					565:565	0.9%	562:565	0.9% NaCl+HES 130	562:578	The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%.
32248158	4	14	theme	NaCl+mannitol	608:620	arg1	%					624:624	0.9% NaCl+mannitol 15%	603:624	0.9% NaCl+mannitol 15%	603:624	The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%.
32248158	2	15	with	patients	341:348	arg1	AIS					355:357	AIS	355:357	AIS	355:357	PATIENTS AND METHODS Materials and methods: The study included 100 patients with AIS.
32248158	8	16	dep	Conclusions	1203:1213	arg1	showed					1276:1281	showed	1276:1281	showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain	1276:1579	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	6	17	theme	flow	823:826	arg1	velocity					805:812	specific volume velocity	789:812	specific volume velocity of blood flow per 100 grams of brain substance	789:859	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	8	18	theme	data	1236:1239	arg1	analysis					1220:1227	The analysis	1216:1227	The analysis of the data of treatment the patients with AIS	1216:1274	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	4	19	dep	%	545:545	arg1	0.9					542:544	0.9	542:544	0.9	542:544	The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%.
32248158	6	20	theme	%	895:895	arg1	NaCl					897:900	0.9% NaCl	892:900	0.9% NaCl	892:900	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	8	21	theme	treatment	1244:1252	arg1	data					1236:1239	the data	1232:1239	the data of treatment the patients with AIS	1232:1274	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	7	22	with	patients	1041:1048	arg1	HES					1055:1057	HES 130	1055:1061	HES 130	1055:1061	In patients with HES 130 solution cerebral blood flow increases by 14.2%, whereas when applied HAES-LX-5% during 7 days, it increases by 43.2% (p=0.004).
32248158	5	23	theme	doppler	715:721	arg1	ultrasound					723:732	doppler ultrasound	715:732	doppler ultrasound of cerebral arteries	715:753	Evaluation of cerebral hemodynamic (indexes of cerebral blood flow) was performed using doppler ultrasound of cerebral arteries.
32248158	8	24	theme	blood	1522:1526	arg1	flow					1528:1531	cerebral blood flow	1513:1531	cerebral blood flow	1513:1531	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	0	25	from	Influence	0:8	arg1	hemodynamics					81:92	cerebral hemodynamics	72:92	cerebral hemodynamics in patients with acute ischemic stroke	72:131	Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke.
32248158	3	26	used	used	395:398	arg2	solutions					380:388	the investigated solutions	363:388	the investigated solutions	363:388	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	0	27	theme	acute	111:115	arg1	stroke					126:131	acute ischemic stroke	111:131	acute ischemic stroke	111:131	Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke.
32248158	0	28	theme	cerebral	72:79	arg1	hemodynamics					81:92	cerebral hemodynamics	72:92	cerebral hemodynamics in patients with acute ischemic stroke	72:131	Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke.
32248158	3	29	theme	investigated	367:378	arg1	solutions					380:388	the investigated solutions	363:388	the investigated solutions	363:388	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	1	30	theme	cerebral	230:237	arg1	hemodynamics					239:250	cerebral hemodynamics	230:250	cerebral hemodynamics in patients with AIS	230:271	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
32248158	1	31	dep	aim	148:150	arg1	Investigate					153:163	Investigate	153:163	Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS	153:271	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
32248158	3	32	theme	0.9	411:413	arg1	%					414:414	%	414:414	%	414:414	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	0	33	theme	different	13:21	arg1	composition					35:45	different qualitative composition	13:45	different qualitative composition of infusion solutions	13:67	Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke.
32248158	6	34	theme	%	909:909	arg1	NaCl+mannitol					911:923	0.9% NaCl+mannitol	906:923	0.9% NaCl+mannitol	906:923	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	0	35	theme	composition	35:45	arg1	Influence					0:8	Influence	0:8	Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke.	0:132	Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke.
32248158	5	36	theme	blood	683:687	arg1	flow					689:692	cerebral blood flow	674:692	cerebral blood flow	674:692	Evaluation of cerebral hemodynamic (indexes of cerebral blood flow) was performed using doppler ultrasound of cerebral arteries.
32248158	4	37	dep	%	565:565	arg1	NaCl+HES					567:574	NaCl+HES	567:574	NaCl+HES	567:574	The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%.
32248158	3	38	theme	hyperosmolar	422:433	arg1	NaCl					416:419	isosmolar 0.9% NaCl	401:419	isosmolar 0.9% NaCl	401:419	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	3	38	theme	hyperosmolar	422:433	arg1	mannitol					435:442	hyperosmolar mannitol	422:442	hyperosmolar mannitol 15%	422:446	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	0	39	theme	infusion	50:57	arg1	solutions					59:67	infusion solutions	50:67	infusion solutions	50:67	Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke.
32248158	6	40	theme	brain	975:979	arg1	flow					963:966	the blood flow	953:966	the blood flow of the brain	953:979	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	8	41	theme	cerebral	1331:1338	arg1	circulation					1340:1350	the cerebral circulation	1327:1350	the cerebral circulation	1327:1350	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	8	42	theme	CONCLUSION	1192:1201	arg1	Conclusions					1203:1213	CONCLUSION Conclusions	1192:1213	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.	1192:1580	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	2	43	theme	METHODS	287:293	arg1	Materials					295:303	PATIENTS AND METHODS Materials	274:303	PATIENTS AND METHODS Materials	274:303	PATIENTS AND METHODS Materials and methods: The study included 100 patients with AIS.
32248158	1	44	from	effect	169:174	arg1	hemodynamics					239:250	cerebral hemodynamics	230:250	cerebral hemodynamics in patients with AIS	230:271	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
32248158	1	45	dep	NaCl	184:187	arg1	%					225:225	15%	223:225	15%	223:225	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
32248158	1	46	theme	%	208:208	arg1	effect					169:174	the effect	165:174	the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS	165:271	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
32248158	5	47	theme	flow	689:692	arg1	indexes					663:669	indexes	663:669	indexes of cerebral blood flow	663:692	Evaluation of cerebral hemodynamic (indexes of cerebral blood flow) was performed using doppler ultrasound of cerebral arteries.
32248158	6	48	theme	blood	817:821	arg1	flow					823:826	blood flow	817:826	blood flow per 100 grams of brain substance	817:859	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	7	49	theme	cerebral	1072:1079	arg1	flow					1087:1090	solution cerebral blood flow	1063:1090	solution cerebral blood flow	1063:1090	In patients with HES 130 solution cerebral blood flow increases by 14.2%, whereas when applied HAES-LX-5% during 7 days, it increases by 43.2% (p=0.004).
32248158	8	50	theme	brain	1575:1579	arg1	hypoperfusion					1554:1566	hypoperfusion	1554:1566	hypoperfusion of the brain	1554:1579	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	3	51	theme	15	444:445	arg1	%					446:446	%	446:446	%	446:446	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	8	52	theme	0.9	1425:1427	arg1	%					1428:1428	%	1428:1428	%	1428:1428	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	1	53	theme	mannitol	214:221	arg1	effect					169:174	the effect	165:174	the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS	165:271	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
32248158	6	54	theme	velocity	805:812	arg1	dynamics					777:784	The dynamics	773:784	The dynamics of specific volume velocity of blood flow per 100 grams of brain substance	773:859	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	4	55	theme	control	514:520	arg1	group					522:526	The control group	510:526	The control group	510:526	The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%.
32248158	8	56	theme	NaCl	1430:1433	arg1	NaCl+mannitol					1459:1471	0.9% NaCl+mannitol	1454:1471	0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain	1454:1579	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	8	56	theme	NaCl	1430:1433	arg1	group					1435:1439	the 0.9% NaCl group	1421:1439	the 0.9% NaCl group	1421:1439	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	6	57	theme	specific	789:796	arg1	velocity					805:812	specific volume velocity	789:812	specific volume velocity of blood flow per 100 grams of brain substance	789:859	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	8	58	theme	infusion	1385:1392	arg1	%					1412:1412	the polyfunctional infusion solution HAES-LX-5%	1366:1412	the polyfunctional infusion solution HAES-LX-5%	1366:1412	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	6	59	from	tendency	932:939	arg1	group					883:887	the group	879:887	the group of 0.9% NaCl and 0.9% NaCl+mannitol	879:923	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	6	59	from	tendency	932:939	arg1	NaCl+mannitol					911:923	0.9% NaCl+mannitol	906:923	0.9% NaCl+mannitol	906:923	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	6	59	from	tendency	932:939	arg1	NaCl					897:900	0.9% NaCl	892:900	0.9% NaCl	892:900	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	2	60	theme	PATIENTS	274:281	arg1	Materials					295:303	PATIENTS AND METHODS Materials	274:303	PATIENTS AND METHODS Materials	274:303	PATIENTS AND METHODS Materials and methods: The study included 100 patients with AIS.
32248158	1	61	theme	0.9	179:181	arg1	%					182:182	%	182:182	%	182:182	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
32248158	0	62	with	patients	97:104	arg1	stroke					126:131	acute ischemic stroke	111:131	acute ischemic stroke	111:131	Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke.
32248158	8	63	theme	%	1457:1457	arg1	NaCl+mannitol					1459:1471	0.9% NaCl+mannitol	1454:1471	0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain	1454:1579	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	1	64	theme	NaCl	184:187	arg1	effect					169:174	the effect	165:174	the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS	165:271	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
32248158	6	65	theme	brain	845:849	arg1	substance					851:859	brain substance	845:859	brain substance	845:859	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	4	66	dep	received	528:535	arg1	compared					552:559	compared	552:559	compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%	552:624	The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%.
32248158	5	67	theme	cerebral	737:744	arg1	arteries					746:753	cerebral arteries	737:753	cerebral arteries	737:753	Evaluation of cerebral hemodynamic (indexes of cerebral blood flow) was performed using doppler ultrasound of cerebral arteries.
32248158	4	68	theme	%	606:606	arg1	%					565:565	0.9%	562:565	0.9% NaCl+HES 130	562:578	The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%.
32248158	4	68	theme	%	606:606	arg1	%					624:624	0.9% NaCl+mannitol 15%	603:624	0.9% NaCl+mannitol 15%	603:624	The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%.
32248158	4	69	dep	NaCl	547:550	arg1	%					545:545	%	545:545	%	545:545	The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%.
32248158	1	70	theme	OBJECTIVE	134:142	arg1	aim					148:150	OBJECTIVE The aim	134:150	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.	134:272	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
32248158	6	71	theme	NaCl	897:900	arg1	group					883:887	the group	879:887	the group of 0.9% NaCl and 0.9% NaCl+mannitol	879:923	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	6	71	theme	NaCl	897:900	arg1	NaCl+mannitol					911:923	0.9% NaCl+mannitol	906:923	0.9% NaCl+mannitol	906:923	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	6	71	theme	NaCl	897:900	arg1	NaCl					897:900	0.9% NaCl	892:900	0.9% NaCl	892:900	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	5	72	theme	hemodynamic	650:660	arg1	Evaluation					627:636	Evaluation	627:636	Evaluation of cerebral hemodynamic (indexes of cerebral blood flow)	627:693	Evaluation of cerebral hemodynamic (indexes of cerebral blood flow) was performed using doppler ultrasound of cerebral arteries.
32248158	8	73	theme	dynamics	1501:1508	arg1	decrease					1485:1492	a decrease	1483:1492	a decrease	1483:1492	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	6	74	theme	0.9	892:894	arg1	%					895:895	%	895:895	%	895:895	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	8	75	theme	cerebral	1513:1520	arg1	flow					1528:1531	cerebral blood flow	1513:1531	cerebral blood flow	1513:1531	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	8	76	theme	flow	1528:1531	arg1	dynamics					1501:1508	the dynamics	1497:1508	the dynamics of cerebral blood flow	1497:1531	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	8	77	theme	best	1287:1290	arg1	p=0.004					1300:1306	p=0.004	1300:1306	p=0.004	1300:1306	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	8	77	theme	best	1287:1290	arg1	effect					1292:1297	the best effect	1283:1297	the best effect (p=0.004) of improvement of the cerebral circulation	1283:1350	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	0	78	theme	ischemic	117:124	arg1	stroke					126:131	acute ischemic stroke	111:131	acute ischemic stroke	111:131	Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke.
32248158	7	79	dep	increases	1092:1100	arg1	whereas					1112:1118	whereas	1112:1118	whereas	1112:1118	In patients with HES 130 solution cerebral blood flow increases by 14.2%, whereas when applied HAES-LX-5% during 7 days, it increases by 43.2% (p=0.004).
32248158	8	80	with	patients	1258:1265	arg1	AIS					1272:1274	AIS	1272:1274	AIS	1272:1274	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	0	81	theme	qualitative	23:33	arg1	composition					35:45	different qualitative composition	13:45	different qualitative composition of infusion solutions	13:67	Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke.
32248158	8	82	dep	treatment	1244:1252	arg1	patients					1258:1265	the patients	1254:1265	treatment the patients with AIS	1244:1274	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	6	83	theme	NaCl+mannitol	911:923	arg1	group					883:887	the group	879:887	the group of 0.9% NaCl and 0.9% NaCl+mannitol	879:923	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	6	83	theme	NaCl+mannitol	911:923	arg1	NaCl+mannitol					911:923	0.9% NaCl+mannitol	906:923	0.9% NaCl+mannitol	906:923	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	6	83	theme	NaCl+mannitol	911:923	arg1	NaCl					897:900	0.9% NaCl	892:900	0.9% NaCl	892:900	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	8	84	theme	improvement	1312:1322	arg1	p=0.004					1300:1306	p=0.004	1300:1306	p=0.004	1300:1306	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	8	84	theme	improvement	1312:1322	arg1	effect					1292:1297	the best effect	1283:1297	the best effect (p=0.004) of improvement of the cerebral circulation	1283:1350	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	2	85	dep	Materials	295:303	arg1	included					328:335	included	328:335	included 100 patients with AIS	328:357	PATIENTS AND METHODS Materials and methods: The study included 100 patients with AIS.
32248158	3	86	theme	%	414:414	arg1	NaCl					416:419	isosmolar 0.9% NaCl	401:419	isosmolar 0.9% NaCl	401:419	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	3	86	theme	%	414:414	arg1	mannitol					435:442	hyperosmolar mannitol	422:442	hyperosmolar mannitol 15%	422:446	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	3	86	theme	%	414:414	arg1	HES					468:470	colloid-isoosmolar HES 130	449:474	colloid-isoosmolar HES 130	449:474	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	5	87	theme	cerebral	674:681	arg1	flow					689:692	cerebral blood flow	674:692	cerebral blood flow	674:692	Evaluation of cerebral hemodynamic (indexes of cerebral blood flow) was performed using doppler ultrasound of cerebral arteries.
32248158	1	88	theme	HES	190:192	arg1	effect					169:174	the effect	165:174	the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS	165:271	OBJECTIVE The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
32248158	6	89	theme	0.9	906:908	arg1	%					909:909	%	909:909	%	909:909	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	6	90	dep	RESULTS	756:762	arg1	%					1026:1026	2.8%	1023:1026	2.8%	1023:1026	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	6	90	dep	RESULTS	756:762	arg1	%					1035:1035	7.5%	1032:1035	7.5%	1032:1035	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	6	90	dep	RESULTS	756:762	arg1	Results					764:770	Results	764:770	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.	756:1036	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	6	90	dep	RESULTS	756:762	arg1	indicates					861:869	indicates	861:869	indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively	861:1020	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	3	91	theme	isosmolar	401:409	arg1	NaCl					416:419	isosmolar 0.9% NaCl	401:419	isosmolar 0.9% NaCl	401:419	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	3	91	theme	isosmolar	401:409	arg1	mannitol					435:442	hyperosmolar mannitol	422:442	hyperosmolar mannitol 15%	422:446	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	3	91	theme	isosmolar	401:409	arg1	HES					468:470	colloid-isoosmolar HES 130	449:474	colloid-isoosmolar HES 130	449:474	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	0	92	theme	solutions	59:67	arg1	composition					35:45	different qualitative composition	13:45	different qualitative composition of infusion solutions	13:67	Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke.
32248158	8	93	theme	circulation	1340:1350	arg1	p=0.004					1300:1306	p=0.004	1300:1306	p=0.004	1300:1306	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	8	93	theme	circulation	1340:1350	arg1	effect					1292:1297	the best effect	1283:1297	the best effect (p=0.004) of improvement of the cerebral circulation	1283:1350	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	8	94	theme	%	1412:1412	arg1	use					1359:1361	the use	1355:1361	the use of the polyfunctional infusion solution HAES-LX-5%	1355:1412	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	4	95	dep	%	584:584	arg1	%					600:600	NaCl+HAES-LX-5%	586:600	0.9% NaCl+HAES-LX-5%	581:600	The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%.
32248158	7	96	theme	blood	1081:1085	arg1	flow					1087:1090	solution cerebral blood flow	1063:1090	solution cerebral blood flow	1063:1090	In patients with HES 130 solution cerebral blood flow increases by 14.2%, whereas when applied HAES-LX-5% during 7 days, it increases by 43.2% (p=0.004).
32248158	6	97	theme	blood	957:961	arg1	flow					963:966	the blood flow	953:966	the blood flow of the brain	953:979	RESULTS Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%.
32248158	7	98	theme	solution	1063:1070	arg1	flow					1087:1090	solution cerebral blood flow	1063:1090	solution cerebral blood flow	1063:1090	In patients with HES 130 solution cerebral blood flow increases by 14.2%, whereas when applied HAES-LX-5% during 7 days, it increases by 43.2% (p=0.004).
32248158	3	99	theme	colloid-isoosmolar	449:466	arg1	HES					468:470	colloid-isoosmolar HES 130	449:474	colloid-isoosmolar HES 130	449:474	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	3	99	theme	colloid-isoosmolar	449:466	arg1	NaCl					416:419	isosmolar 0.9% NaCl	401:419	isosmolar 0.9% NaCl	401:419	As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%.
32248158	8	100	theme	%	1428:1428	arg1	NaCl+mannitol					1459:1471	0.9% NaCl+mannitol	1454:1471	0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain	1454:1579	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32248158	8	100	theme	%	1428:1428	arg1	group					1435:1439	the 0.9% NaCl group	1421:1439	the 0.9% NaCl group	1421:1439	CONCLUSION Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
32259407	10	0	theme	initial	1480:1486	arg1	environment					1504:1514	the initial caries-inducing environment	1476:1514	the initial caries-inducing environment	1476:1514	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment may lead to the development of materials and procedures for the prevention of dental caries.
32259407	4	1	theme	%	737:737	arg1	sucrose					739:745	0.2% sucrose	734:745	0.2% sucrose	734:745	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	6	2	theme	Total	941:945	arg1	counts					956:961	Total bacteria counts	941:961	Total bacteria counts	941:961	Total bacteria counts were determined by Q-PCR.
32259407	9	3	theme	other	1209:1213	arg1	groups					1215:1220	the other groups	1205:1220	the other groups	1205:1220	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	1	4	theme	supply	199:204	arg1	duration					159:166	duration	159:166	duration of culture	159:177	PURPOSE To analyze changes in pH and bacterial flora with duration of culture and timing of sugar supply using a polymicrobial biofilm model.
32259407	1	4	theme	supply	199:204	arg1	timing					183:188	timing	183:188	timing of sugar supply	183:204	PURPOSE To analyze changes in pH and bacterial flora with duration of culture and timing of sugar supply using a polymicrobial biofilm model.
32259407	10	5	theme	environment	1504:1514	arg1	model					1467:1471	a biofilm model	1457:1471	a biofilm model of the initial caries-inducing environment	1457:1514	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment may lead to the development of materials and procedures for the prevention of dental caries.
32259407	3	6	contain	containing	414:423	arg2	sucrose					430:436	0.2% sucrose	425:436	0.2% sucrose	425:436	Stimulated saliva from an adult was collected on a glass slide and added to unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours.
32259407	3	6	contain	containing	414:423	arg1	medium					407:412	unbuffered McBain medium	389:412	unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours	389:491	Stimulated saliva from an adult was collected on a glass slide and added to unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours.
32259407	3	6	contain	containing	414:423	arg2	cultivated					442:451	cultivated	442:451	cultivated	442:451	Stimulated saliva from an adult was collected on a glass slide and added to unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours.
32259407	9	7	dep	Groups	1365:1370	arg1	B					1372:1372	B	1372:1372	B	1372:1372	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	9	7	dep	Groups	1365:1370	arg1	E					1381:1381	E	1381:1381	E	1381:1381	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	9	7	dep	Groups	1365:1370	arg1	Groups					1365:1370	Groups B, D and E	1365:1381	Groups B, D and E	1365:1381	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	9	7	dep	Groups	1365:1370	arg1	D					1375:1375	D	1375:1375	D	1375:1375	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	8	8	dep	presence	1120:1127	arg1	the					1116:1118	the	1116:1118	the	1116:1118	RESULTS The pH of spent medium depended on the presence or absence of sucrose.
32259407	8	9	theme	spent	1091:1095	arg1	medium					1097:1102	spent medium	1091:1102	spent medium	1091:1102	RESULTS The pH of spent medium depended on the presence or absence of sucrose.
32259407	9	10	theme	E.	1251:1252	arg1	components					1264:1273	E. Principal components	1251:1273	Group E. Principal components	1245:1273	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	9	11	from	variation	1318:1326	arg1	B					1372:1372	B	1372:1372	B	1372:1372	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	9	11	from	variation	1318:1326	arg1	E					1381:1381	E	1381:1381	E	1381:1381	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	9	11	from	variation	1318:1326	arg1	Groups					1365:1370	Groups B, D and E	1365:1381	Groups B, D and E	1365:1381	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	9	11	from	variation	1318:1326	arg1	D					1375:1375	D	1375:1375	D	1375:1375	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	2	12	dep	Exterkate	296:304	arg1	al					309:310	Exterkate et al	296:310	Exterkate et al	296:310	METHODS The biofilm was prepared using the method of Exterkate et al.
32259407	0	13	from	environment	88:98	arg1	analysis					14:21	Comprehensive analysis	0:21	Comprehensive analysis of bacterial flora of a biofilm model in initial caries-inducing environment.	0:99	Comprehensive analysis of bacterial flora of a biofilm model in initial caries-inducing environment.
32259407	10	14	theme	SIGNIFICANCE	1411:1422	arg1	Inspection					1424:1433	CLINICAL SIGNIFICANCE Inspection	1402:1433	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment	1402:1514	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment may lead to the development of materials and procedures for the prevention of dental caries.
32259407	0	15	theme	model	55:59	arg1	flora					36:40	bacterial flora	26:40	bacterial flora of a biofilm model in initial caries-inducing environment	26:98	Comprehensive analysis of bacterial flora of a biofilm model in initial caries-inducing environment.
32259407	1	16	theme	bacterial	138:146	arg1	flora					148:152	bacterial flora	138:152	bacterial flora	138:152	PURPOSE To analyze changes in pH and bacterial flora with duration of culture and timing of sugar supply using a polymicrobial biofilm model.
32259407	0	17	theme	initial	64:70	arg1	environment					88:98	initial caries-inducing environment	64:98	initial caries-inducing environment	64:98	Comprehensive analysis of bacterial flora of a biofilm model in initial caries-inducing environment.
32259407	5	18	theme	spent	914:918	arg1	medium					920:925	all spent medium	910:925	all spent medium	910:925	The pH of all spent medium was measured.
32259407	9	19	dep	Group	1245:1249	arg1	components					1264:1273	E. Principal components	1251:1273	Group E. Principal components	1245:1273	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	4	20	theme	%	659:659	arg1	sucrose					661:667	0.2% sucrose	656:667	0.2% sucrose for 96, 192 and 288 hours	656:693	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	3	21	theme	McBain	400:405	arg1	medium					407:412	unbuffered McBain medium	389:412	unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours	389:491	Stimulated saliva from an adult was collected on a glass slide and added to unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours.
32259407	9	22	theme	wider	1312:1316	arg1	variation					1318:1326	wider variation	1312:1326	wider variation of bacterial flora of the biofilm in Groups B, D and E	1312:1381	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	0	23	from	flora	36:40	arg1	environment					88:98	initial caries-inducing environment	64:98	initial caries-inducing environment	64:98	Comprehensive analysis of bacterial flora of a biofilm model in initial caries-inducing environment.
32259407	0	24	theme	Comprehensive	0:12	arg1	analysis					14:21	Comprehensive analysis	0:21	Comprehensive analysis of bacterial flora of a biofilm model in initial caries-inducing environment.	0:99	Comprehensive analysis of bacterial flora of a biofilm model in initial caries-inducing environment.
32259407	1	25	with	changes	120:126	arg1	duration					159:166	duration	159:166	duration of culture	159:177	PURPOSE To analyze changes in pH and bacterial flora with duration of culture and timing of sugar supply using a polymicrobial biofilm model.
32259407	1	25	with	changes	120:126	arg1	timing					183:188	timing	183:188	timing of sugar supply	183:204	PURPOSE To analyze changes in pH and bacterial flora with duration of culture and timing of sugar supply using a polymicrobial biofilm model.
32259407	3	26	theme	%	428:428	arg1	sucrose					430:436	0.2% sucrose	425:436	0.2% sucrose	425:436	Stimulated saliva from an adult was collected on a glass slide and added to unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours.
32259407	9	27	theme	flora	1341:1345	arg1	variation					1318:1326	wider variation	1312:1326	wider variation of bacterial flora of the biofilm in Groups B, D and E	1312:1381	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	4	28	theme	%	830:830	arg1	sucrose					832:838	0.2% sucrose	827:838	0.2% sucrose for 96 hours	827:851	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	10	29	theme	dental	1594:1599	arg1	caries					1601:1606	dental caries	1594:1606	dental caries	1594:1606	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment may lead to the development of materials and procedures for the prevention of dental caries.
32259407	0	30	theme	flora	36:40	arg1	analysis					14:21	Comprehensive analysis	0:21	Comprehensive analysis of bacterial flora of a biofilm model in initial caries-inducing environment.	0:99	Comprehensive analysis of bacterial flora of a biofilm model in initial caries-inducing environment.
32259407	3	31	theme	glass	364:368	arg1	slide					370:374	a glass slide	362:374	a glass slide	362:374	Stimulated saliva from an adult was collected on a glass slide and added to unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours.
32259407	4	32	theme	Group	813:817	arg1	D					819:819	Group D	813:819	Group D	813:819	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	10	33	theme	flora	1448:1452	arg1	Inspection					1424:1433	CLINICAL SIGNIFICANCE Inspection	1402:1433	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment	1402:1514	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment may lead to the development of materials and procedures for the prevention of dental caries.
32259407	9	34	theme	Total	1152:1156	arg1	counts					1167:1172	Total bacteria counts	1152:1172	Total bacteria counts	1152:1172	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	4	35	dep	Control	623:629	arg1	C					648:648	C	648:648	C	648:648	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	4	35	dep	Control	623:629	arg1	A					642:642	A	642:642	A	642:642	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	7	36	theme	rDNA	1067:1070	arg1	sequencing					1049:1058	next-generation sequencing	1033:1058	next-generation sequencing of 16S rDNA	1033:1070	The bacterial composition was determined by next-generation sequencing of 16S rDNA.
32259407	10	37	theme	model	1467:1471	arg1	flora					1448:1452	bacterial flora	1438:1452	bacterial flora of a biofilm model of the initial caries-inducing environment	1438:1514	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment may lead to the development of materials and procedures for the prevention of dental caries.
32259407	1	38	theme	polymicrobial	214:226	arg1	model					236:240	a polymicrobial biofilm model	212:240	a polymicrobial biofilm model	212:240	PURPOSE To analyze changes in pH and bacterial flora with duration of culture and timing of sugar supply using a polymicrobial biofilm model.
32259407	7	39	theme	bacterial	993:1001	arg1	composition					1003:1013	The bacterial composition	989:1013	The bacterial composition	989:1013	The bacterial composition was determined by next-generation sequencing of 16S rDNA.
32259407	7	40	theme	next-generation	1033:1047	arg1	sequencing					1049:1058	next-generation sequencing	1033:1058	next-generation sequencing of 16S rDNA	1033:1070	The bacterial composition was determined by next-generation sequencing of 16S rDNA.
32259407	10	41	theme	caries-inducing	1488:1502	arg1	environment					1504:1514	the initial caries-inducing environment	1476:1514	the initial caries-inducing environment	1476:1514	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment may lead to the development of materials and procedures for the prevention of dental caries.
32259407	4	42	from	Groups	635:640	arg1	B					720:720	B	720:720	B	720:720	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	4	42	from	Groups	635:640	arg1	Groups					713:718	Groups B and E	713:726	Groups B and E	713:726	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	4	42	from	Groups	635:640	arg1	E					726:726	E	726:726	E	726:726	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	4	43	from	hours	803:807	arg1	D					819:819	Group D	813:819	Group D	813:819	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	9	44	theme	other	1388:1392	arg1	groups					1394:1399	other groups	1388:1399	other groups	1388:1399	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	4	45	from	Control	623:629	arg1	B					720:720	B	720:720	B	720:720	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	4	45	from	Control	623:629	arg1	Groups					713:718	Groups B and E	713:726	Groups B and E	713:726	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	4	45	from	Control	623:629	arg1	E					726:726	E	726:726	E	726:726	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	6	46	theme	bacteria	947:954	arg1	counts					956:961	Total bacteria counts	941:961	Total bacteria counts	941:961	Total bacteria counts were determined by Q-PCR.
32259407	2	47	theme	Exterkate	296:304	arg1	method					286:291	the method	282:291	the method of Exterkate et al	282:310	METHODS The biofilm was prepared using the method of Exterkate et al.
32259407	1	48	theme	culture	171:177	arg1	duration					159:166	duration	159:166	duration of culture	159:177	PURPOSE To analyze changes in pH and bacterial flora with duration of culture and timing of sugar supply using a polymicrobial biofilm model.
32259407	1	48	theme	culture	171:177	arg1	timing					183:188	timing	183:188	timing of sugar supply	183:204	PURPOSE To analyze changes in pH and bacterial flora with duration of culture and timing of sugar supply using a polymicrobial biofilm model.
32259407	4	49	theme	0.2	734:736	arg1	%					737:737	%	737:737	%	737:737	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	2	50	dep	METHODS	243:249	arg1	prepared					267:274	prepared	267:274	was prepared using the method of Exterkate et al	263:310	METHODS The biofilm was prepared using the method of Exterkate et al.
32259407	4	51	from	groups	608:613	arg1	Groups					635:640	Groups	635:640	Groups	635:640	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	4	51	from	groups	608:613	arg1	Control					623:629	the Control	619:629	the Control	619:629	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	3	52	theme	anaerobic	459:467	arg1	conditions					469:478	anaerobic conditions	459:478	anaerobic conditions for 10 hours	459:491	Stimulated saliva from an adult was collected on a glass slide and added to unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours.
32259407	10	53	theme	materials	1547:1555	arg1	development					1532:1542	the development	1528:1542	the development of materials and procedures for the prevention of dental caries	1528:1606	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment may lead to the development of materials and procedures for the prevention of dental caries.
32259407	1	54	theme	sugar	193:197	arg1	supply					199:204	sugar supply	193:204	sugar supply	193:204	PURPOSE To analyze changes in pH and bacterial flora with duration of culture and timing of sugar supply using a polymicrobial biofilm model.
32259407	3	55	from	adult	339:343	arg1	saliva					324:329	Stimulated saliva	313:329	Stimulated saliva from an adult	313:343	Stimulated saliva from an adult was collected on a glass slide and added to unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours.
32259407	9	56	theme	lower	1236:1240	arg1	analysis					1275:1282	markedly lower in Group E. Principal components analysis	1227:1282	markedly lower in Group E. Principal components analysis	1227:1282	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	4	57	theme	0.2	656:658	arg1	%					659:659	%	659:659	%	659:659	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	10	58	theme	procedures	1561:1570	arg1	development					1532:1542	the development	1528:1542	the development of materials and procedures for the prevention of dental caries	1528:1606	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment may lead to the development of materials and procedures for the prevention of dental caries.
32259407	9	59	theme	Principal	1254:1262	arg1	components					1264:1273	E. Principal components	1251:1273	Group E. Principal components	1245:1273	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	3	60	theme	Stimulated	313:322	arg1	saliva					324:329	Stimulated saliva	313:329	Stimulated saliva from an adult	313:343	Stimulated saliva from an adult was collected on a glass slide and added to unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours.
32259407	8	61	theme	medium	1097:1102	arg1	pH					1085:1086	RESULTS The pH	1073:1086	RESULTS The pH of spent medium	1073:1102	RESULTS The pH of spent medium depended on the presence or absence of sucrose.
32259407	0	62	theme	caries-inducing	72:86	arg1	environment					88:98	initial caries-inducing environment	64:98	initial caries-inducing environment	64:98	Comprehensive analysis of bacterial flora of a biofilm model in initial caries-inducing environment.
32259407	0	63	from	analysis	14:21	arg1	environment					88:98	initial caries-inducing environment	64:98	initial caries-inducing environment	64:98	Comprehensive analysis of bacterial flora of a biofilm model in initial caries-inducing environment.
32259407	5	64	theme	medium	920:925	arg1	pH					904:905	The pH	900:905	The pH of all spent medium	900:925	The pH of all spent medium was measured.
32259407	9	65	theme	cluster	1288:1294	arg1	analysis					1296:1303	cluster analysis	1288:1303	cluster analysis	1288:1303	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	4	66	theme	288	685:687	arg1	hours					689:693	96, 192 and 288 hours	673:693	hours	689:693	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	4	67	theme	saliva-free	533:543	arg1	medium					545:550	saliva-free medium	533:550	saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose	533:745	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	8	68	theme	sucrose	1143:1149	arg1	absence					1132:1138	absence	1132:1138	absence	1132:1138	RESULTS The pH of spent medium depended on the presence or absence of sucrose.
32259407	8	68	theme	sucrose	1143:1149	arg1	presence					1120:1127	presence	1120:1127	presence	1120:1127	RESULTS The pH of spent medium depended on the presence or absence of sucrose.
32259407	3	69	theme	unbuffered	389:398	arg1	medium					407:412	unbuffered McBain medium	389:412	unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours	389:491	Stimulated saliva from an adult was collected on a glass slide and added to unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours.
32259407	0	70	theme	bacterial	26:34	arg1	flora					36:40	bacterial flora	26:40	bacterial flora of a biofilm model in initial caries-inducing environment	26:98	Comprehensive analysis of bacterial flora of a biofilm model in initial caries-inducing environment.
32259407	1	71	from	changes	120:126	arg1	pH					131:132	pH	131:132	pH	131:132	PURPOSE To analyze changes in pH and bacterial flora with duration of culture and timing of sugar supply using a polymicrobial biofilm model.
32259407	1	71	from	changes	120:126	arg1	flora					148:152	bacterial flora	138:152	bacterial flora	138:152	PURPOSE To analyze changes in pH and bacterial flora with duration of culture and timing of sugar supply using a polymicrobial biofilm model.
32259407	9	72	theme	bacterial	1331:1339	arg1	flora					1341:1345	bacterial flora	1331:1345	bacterial flora of the biofilm	1331:1360	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	10	73	theme	caries	1601:1606	arg1	prevention					1580:1589	the prevention	1576:1589	the prevention of dental caries	1576:1606	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment may lead to the development of materials and procedures for the prevention of dental caries.
32259407	4	74	theme	96	673:674	arg1	hours					689:693	96, 192 and 288 hours	673:693	hours	689:693	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	10	75	theme	CLINICAL	1402:1409	arg1	Inspection					1424:1433	CLINICAL SIGNIFICANCE Inspection	1402:1433	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment	1402:1514	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment may lead to the development of materials and procedures for the prevention of dental caries.
32259407	8	76	theme	RESULTS	1073:1079	arg1	pH					1085:1086	RESULTS The pH	1073:1086	RESULTS The pH of spent medium	1073:1102	RESULTS The pH of spent medium depended on the presence or absence of sucrose.
32259407	4	77	theme	0.2	827:829	arg1	%					830:830	%	830:830	%	830:830	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	3	78	theme	0.2	425:427	arg1	%					428:428	%	428:428	%	428:428	Stimulated saliva from an adult was collected on a glass slide and added to unbuffered McBain medium containing 0.2% sucrose and cultivated under anaerobic conditions for 10 hours.
32259407	0	79	theme	biofilm	47:53	arg1	model					55:59	a biofilm model	45:59	a biofilm model	45:59	Comprehensive analysis of bacterial flora of a biofilm model in initial caries-inducing environment.
32259407	9	80	theme	biofilm	1354:1360	arg1	flora					1341:1345	bacterial flora	1331:1345	bacterial flora of the biofilm	1331:1360	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	10	81	theme	bacterial	1438:1446	arg1	flora					1448:1452	bacterial flora	1438:1452	bacterial flora of a biofilm model of the initial caries-inducing environment	1438:1514	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment may lead to the development of materials and procedures for the prevention of dental caries.
32259407	9	82	theme	bacteria	1158:1165	arg1	counts					1167:1172	Total bacteria counts	1152:1172	Total bacteria counts	1152:1172	Total bacteria counts were higher in A, C and D than the other groups, and markedly lower in Group E. Principal components analysis and cluster analysis showed wider variation of bacterial flora of the biofilm in Groups B, D and E than other groups.
32259407	7	83	theme	16S	1063:1065	arg1	rDNA					1067:1070	16S rDNA	1063:1070	16S rDNA	1063:1070	The bacterial composition was determined by next-generation sequencing of 16S rDNA.
32259407	4	84	dep	Groups	713:718	arg1	B					720:720	B	720:720	B	720:720	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	4	84	dep	Groups	713:718	arg1	Groups					713:718	Groups B and E	713:726	Groups B and E	713:726	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	4	84	dep	Groups	713:718	arg1	E					726:726	E	726:726	E	726:726	Cultivation continued anaerobically in saliva-free medium refreshed twice daily, with or without sucrose, in five groups: in the Control and Groups A and C, with 0.2% sucrose for 96, 192 and 288 hours, respectively; in Groups B and E, with 0.2% sucrose for 96 hours then, respectively, without for 96 and 192 hours; in Group D, with 0.2% sucrose for 96 hours, without for 96 hours, then with for 96 hours.
32259407	10	85	theme	biofilm	1459:1465	arg1	model					1467:1471	a biofilm model	1457:1471	a biofilm model of the initial caries-inducing environment	1457:1514	CLINICAL SIGNIFICANCE Inspection of bacterial flora of a biofilm model of the initial caries-inducing environment may lead to the development of materials and procedures for the prevention of dental caries.
32259407	1	86	theme	biofilm	228:234	arg1	model					236:240	a polymicrobial biofilm model	212:240	a polymicrobial biofilm model	212:240	PURPOSE To analyze changes in pH and bacterial flora with duration of culture and timing of sugar supply using a polymicrobial biofilm model.
34294330	0	0	theme	branched	82:89	arg1	arabinoxylans					91:103	densely branched arabinoxylans	74:103	densely branched arabinoxylans from Plantago ovata	74:123	Viscoelastic behaviour of rapid and slow self-healing hydrogels formed by densely branched arabinoxylans from Plantago ovata seed mucilage.
34294330	4	1	theme	fast'-dissociating	736:753	arg1	junctions					755:763	'slow'- and 'fast'-dissociating junctions	723:763	'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds	723:792	Differences in rheology and gelation of the two hydrogels are found to be associated with the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds, with the 'fast'-dissociating junctions playing an important role in rapid self-healing of the gel.
34294330	2	2	theme	distinct	392:399	arg1	properties					413:422	distinct rheological properties	392:422	distinct rheological properties	392:422	Two arabinoxlyan fractions with similar molecular weight and linkage compositions are chosen to form gels with distinct rheological properties but a similar network structure.
34294330	5	3	theme	slow	1154:1157	arg1	types					1180:1184	the 'slow' and 'fast' junction types	1149:1184	the 'slow' and 'fast' junction types	1149:1184	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	5	4	theme	time-temperature	953:968	arg1	principle					984:992	time-temperature superposition principle	953:992	time-temperature superposition principle	953:992	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	5	5	theme	modulus	941:947	arg1	dependence					919:928	the temperature dependence	903:928	the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation	903:1035	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	5	6	theme	junction	1065:1072	arg1	dissociation					1079:1090	junction zone dissociation	1065:1090	junction zone dissociation	1065:1090	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	3	7	theme	concentration	590:602	arg1	transition					546:555	the sol-gel transition	534:555	the sol-gel transition	534:555	Small and large amplitude oscillatory shear rheology is used to characterise the sol-gel transition as a function of temperature and concentration.
34294330	3	7	theme	concentration	590:602	arg1	function					562:569	a function	560:569	a function of temperature and concentration	560:602	Small and large amplitude oscillatory shear rheology is used to characterise the sol-gel transition as a function of temperature and concentration.
34294330	2	8	theme	molecular	321:329	arg1	weight					331:336	similar molecular weight	313:336	similar molecular weight	313:336	Two arabinoxlyan fractions with similar molecular weight and linkage compositions are chosen to form gels with distinct rheological properties but a similar network structure.
34294330	5	9	theme	superposition	970:982	arg1	principle					984:992	time-temperature superposition principle	953:992	time-temperature superposition principle	953:992	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	2	10	theme	similar	313:319	arg1	weight					331:336	similar molecular weight	313:336	similar molecular weight	313:336	Two arabinoxlyan fractions with similar molecular weight and linkage compositions are chosen to form gels with distinct rheological properties but a similar network structure.
34294330	1	11	theme	hydrogels	182:190	arg1	characterisation					162:177	rheological characterisation	150:177	rheological characterisation of hydrogels formed by highly substituted brush-like arabinoxylans from Plantago ovata seed mucilage	150:278	We report rheological characterisation of hydrogels formed by highly substituted brush-like arabinoxylans from Plantago ovata seed mucilage.
34294330	5	12	theme	fast	1165:1168	arg1	types					1180:1184	the 'slow' and 'fast' junction types	1149:1184	the 'slow' and 'fast' junction types	1149:1184	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	3	13	theme	Small	457:461	arg1	rheology					501:508	Small and large amplitude oscillatory shear rheology	457:508	Small and large amplitude oscillatory shear rheology	457:508	Small and large amplitude oscillatory shear rheology is used to characterise the sol-gel transition as a function of temperature and concentration.
34294330	2	14	theme	similar	430:436	arg1	structure					446:454	a similar network structure	428:454	a similar network structure	428:454	Two arabinoxlyan fractions with similar molecular weight and linkage compositions are chosen to form gels with distinct rheological properties but a similar network structure.
34294330	4	15	theme	different	699:707	arg1	proportion					709:718	the different proportion	695:718	the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds	695:792	Differences in rheology and gelation of the two hydrogels are found to be associated with the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds, with the 'fast'-dissociating junctions playing an important role in rapid self-healing of the gel.
34294330	3	16	theme	large	467:471	arg1	rheology					501:508	Small and large amplitude oscillatory shear rheology	457:508	Small and large amplitude oscillatory shear rheology	457:508	Small and large amplitude oscillatory shear rheology is used to characterise the sol-gel transition as a function of temperature and concentration.
34294330	0	17	theme	Viscoelastic	0:11	arg1	behaviour					13:21	Viscoelastic behaviour	0:21	Viscoelastic behaviour of rapid and slow self-healing hydrogels formed by densely branched arabinoxylans from Plantago ovata	0:123	Viscoelastic behaviour of rapid and slow self-healing hydrogels formed by densely branched arabinoxylans from Plantago ovata seed mucilage.
34294330	5	18	theme	temperature	907:917	arg1	dependence					919:928	the temperature dependence	903:928	the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation	903:1035	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	4	19	theme	fast'-dissociating	805:822	arg1	junctions					824:832	the 'fast'-dissociating junctions	800:832	the 'fast'-dissociating junctions	800:832	Differences in rheology and gelation of the two hydrogels are found to be associated with the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds, with the 'fast'-dissociating junctions playing an important role in rapid self-healing of the gel.
34294330	3	20	theme	amplitude	473:481	arg1	rheology					501:508	Small and large amplitude oscillatory shear rheology	457:508	Small and large amplitude oscillatory shear rheology	457:508	Small and large amplitude oscillatory shear rheology is used to characterise the sol-gel transition as a function of temperature and concentration.
34294330	0	21	theme	rapid	26:30	arg1	hydrogels					54:62	rapid and slow self-healing hydrogels	26:62	rapid and slow self-healing hydrogels formed by densely branched arabinoxylans from Plantago ovata	26:123	Viscoelastic behaviour of rapid and slow self-healing hydrogels formed by densely branched arabinoxylans from Plantago ovata seed mucilage.
34294330	2	22	theme	linkage	342:348	arg1	compositions					350:361	linkage compositions	342:361	linkage compositions	342:361	Two arabinoxlyan fractions with similar molecular weight and linkage compositions are chosen to form gels with distinct rheological properties but a similar network structure.
34294330	1	23	theme	substituted	209:219	arg1	arabinoxylans					232:244	highly substituted brush-like arabinoxylans	202:244	highly substituted brush-like arabinoxylans from Plantago ovata seed mucilage	202:278	We report rheological characterisation of hydrogels formed by highly substituted brush-like arabinoxylans from Plantago ovata seed mucilage.
34294330	4	24	from	Differences	605:615	arg1	gelation					633:640	gelation	633:640	gelation	633:640	Differences in rheology and gelation of the two hydrogels are found to be associated with the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds, with the 'fast'-dissociating junctions playing an important role in rapid self-healing of the gel.
34294330	4	24	from	Differences	605:615	arg1	rheology					620:627	rheology	620:627	rheology	620:627	Differences in rheology and gelation of the two hydrogels are found to be associated with the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds, with the 'fast'-dissociating junctions playing an important role in rapid self-healing of the gel.
34294330	5	25	with	combination	997:1007	arg1	equation					1028:1035	the Arrhenius equation	1014:1035	the Arrhenius equation	1014:1035	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	3	26	theme	temperature	574:584	arg1	transition					546:555	the sol-gel transition	534:555	the sol-gel transition	534:555	Small and large amplitude oscillatory shear rheology is used to characterise the sol-gel transition as a function of temperature and concentration.
34294330	3	26	theme	temperature	574:584	arg1	function					562:569	a function	560:569	a function of temperature and concentration	560:602	Small and large amplitude oscillatory shear rheology is used to characterise the sol-gel transition as a function of temperature and concentration.
34294330	3	27	used	used	513:516	arg2	rheology					501:508	Small and large amplitude oscillatory shear rheology	457:508	Small and large amplitude oscillatory shear rheology	457:508	Small and large amplitude oscillatory shear rheology is used to characterise the sol-gel transition as a function of temperature and concentration.
34294330	1	28	theme	brush-like	221:230	arg1	arabinoxylans					232:244	highly substituted brush-like arabinoxylans	202:244	highly substituted brush-like arabinoxylans from Plantago ovata seed mucilage	202:278	We report rheological characterisation of hydrogels formed by highly substituted brush-like arabinoxylans from Plantago ovata seed mucilage.
34294330	0	29	theme	slow	36:39	arg1	hydrogels					54:62	rapid and slow self-healing hydrogels	26:62	rapid and slow self-healing hydrogels formed by densely branched arabinoxylans from Plantago ovata	26:123	Viscoelastic behaviour of rapid and slow self-healing hydrogels formed by densely branched arabinoxylans from Plantago ovata seed mucilage.
34294330	5	30	theme	principle	984:992	arg1	dependence					919:928	the temperature dependence	903:928	the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation	903:1035	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	2	31	theme	network	438:444	arg1	structure					446:454	a similar network structure	428:454	a similar network structure	428:454	Two arabinoxlyan fractions with similar molecular weight and linkage compositions are chosen to form gels with distinct rheological properties but a similar network structure.
34294330	1	32	dep	Plantago	251:258	arg1	mucilage					271:278	seed mucilage	266:278	Plantago ovata seed mucilage	251:278	We report rheological characterisation of hydrogels formed by highly substituted brush-like arabinoxylans from Plantago ovata seed mucilage.
34294330	1	32	dep	Plantago	251:258	arg1	ovata					260:264	Plantago ovata seed mucilage	251:278	Plantago ovata seed mucilage	251:278	We report rheological characterisation of hydrogels formed by highly substituted brush-like arabinoxylans from Plantago ovata seed mucilage.
34294330	4	33	theme	rapid	863:867	arg1	self-healing					869:880	rapid self-healing	863:880	rapid self-healing of the gel	863:891	Differences in rheology and gelation of the two hydrogels are found to be associated with the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds, with the 'fast'-dissociating junctions playing an important role in rapid self-healing of the gel.
34294330	0	34	theme	hydrogels	54:62	arg1	behaviour					13:21	Viscoelastic behaviour	0:21	Viscoelastic behaviour of rapid and slow self-healing hydrogels formed by densely branched arabinoxylans from Plantago ovata	0:123	Viscoelastic behaviour of rapid and slow self-healing hydrogels formed by densely branched arabinoxylans from Plantago ovata seed mucilage.
34294330	3	35	theme	oscillatory	483:493	arg1	rheology					501:508	Small and large amplitude oscillatory shear rheology	457:508	Small and large amplitude oscillatory shear rheology	457:508	Small and large amplitude oscillatory shear rheology is used to characterise the sol-gel transition as a function of temperature and concentration.
34294330	3	36	theme	sol-gel	538:544	arg1	transition					546:555	the sol-gel transition	534:555	the sol-gel transition	534:555	Small and large amplitude oscillatory shear rheology is used to characterise the sol-gel transition as a function of temperature and concentration.
34294330	3	36	theme	sol-gel	538:544	arg1	function					562:569	a function	560:569	a function of temperature and concentration	560:602	Small and large amplitude oscillatory shear rheology is used to characterise the sol-gel transition as a function of temperature and concentration.
34294330	0	37	theme	self-healing	41:52	arg1	hydrogels					54:62	rapid and slow self-healing hydrogels	26:62	rapid and slow self-healing hydrogels formed by densely branched arabinoxylans from Plantago ovata	26:123	Viscoelastic behaviour of rapid and slow self-healing hydrogels formed by densely branched arabinoxylans from Plantago ovata seed mucilage.
34294330	2	38	with	fractions	298:306	arg1	weight					331:336	similar molecular weight	313:336	similar molecular weight	313:336	Two arabinoxlyan fractions with similar molecular weight and linkage compositions are chosen to form gels with distinct rheological properties but a similar network structure.
34294330	2	38	with	fractions	298:306	arg1	compositions					350:361	linkage compositions	342:361	linkage compositions	342:361	Two arabinoxlyan fractions with similar molecular weight and linkage compositions are chosen to form gels with distinct rheological properties but a similar network structure.
34294330	0	39	from	ovata	119:123	arg1	arabinoxylans					91:103	densely branched arabinoxylans	74:103	densely branched arabinoxylans from Plantago ovata	74:123	Viscoelastic behaviour of rapid and slow self-healing hydrogels formed by densely branched arabinoxylans from Plantago ovata seed mucilage.
34294330	4	40	theme	gel	889:891	arg1	self-healing					869:880	rapid self-healing	863:880	rapid self-healing of the gel	863:891	Differences in rheology and gelation of the two hydrogels are found to be associated with the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds, with the 'fast'-dissociating junctions playing an important role in rapid self-healing of the gel.
34294330	4	41	theme	junctions	755:763	arg1	proportion					709:718	the different proportion	695:718	the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds	695:792	Differences in rheology and gelation of the two hydrogels are found to be associated with the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds, with the 'fast'-dissociating junctions playing an important role in rapid self-healing of the gel.
34294330	1	42	from	Plantago	251:258	arg1	arabinoxylans					232:244	highly substituted brush-like arabinoxylans	202:244	highly substituted brush-like arabinoxylans from Plantago ovata seed mucilage	202:278	We report rheological characterisation of hydrogels formed by highly substituted brush-like arabinoxylans from Plantago ovata seed mucilage.
34294330	4	43	theme	important	845:853	arg1	role					855:858	an important role	842:858	an important role	842:858	Differences in rheology and gelation of the two hydrogels are found to be associated with the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds, with the 'fast'-dissociating junctions playing an important role in rapid self-healing of the gel.
34294330	4	44	theme	slow'-	724:729	arg1	junctions					755:763	'slow'- and 'fast'-dissociating junctions	723:763	'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds	723:792	Differences in rheology and gelation of the two hydrogels are found to be associated with the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds, with the 'fast'-dissociating junctions playing an important role in rapid self-healing of the gel.
34294330	4	45	theme	hydrogen	779:786	arg1	bonds					788:792	hydrogen bonds	779:792	hydrogen bonds	779:792	Differences in rheology and gelation of the two hydrogels are found to be associated with the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds, with the 'fast'-dissociating junctions playing an important role in rapid self-healing of the gel.
34294330	5	46	theme	Arrhenius	1018:1026	arg1	equation					1028:1035	the Arrhenius equation	1014:1035	the Arrhenius equation	1014:1035	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	2	47	theme	arabinoxlyan	285:296	arg1	fractions					298:306	Two arabinoxlyan fractions	281:306	Two arabinoxlyan fractions with similar molecular weight and linkage compositions	281:361	Two arabinoxlyan fractions with similar molecular weight and linkage compositions are chosen to form gels with distinct rheological properties but a similar network structure.
34294330	5	48	from	dependence	919:928	arg1	combination					997:1007	combination	997:1007	combination with the Arrhenius equation	997:1035	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	1	49	theme	rheological	150:160	arg1	characterisation					162:177	rheological characterisation	150:177	rheological characterisation of hydrogels formed by highly substituted brush-like arabinoxylans from Plantago ovata seed mucilage	150:278	We report rheological characterisation of hydrogels formed by highly substituted brush-like arabinoxylans from Plantago ovata seed mucilage.
34294330	4	50	theme	hydrogels	653:661	arg1	gelation					633:640	gelation	633:640	gelation	633:640	Differences in rheology and gelation of the two hydrogels are found to be associated with the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds, with the 'fast'-dissociating junctions playing an important role in rapid self-healing of the gel.
34294330	4	50	theme	hydrogels	653:661	arg1	rheology					620:627	rheology	620:627	rheology	620:627	Differences in rheology and gelation of the two hydrogels are found to be associated with the different proportion of 'slow'- and 'fast'-dissociating junctions stabilised by hydrogen bonds, with the 'fast'-dissociating junctions playing an important role in rapid self-healing of the gel.
34294330	5	51	theme	activation	1042:1051	arg1	402-480 kJ/mol					1112:1125	402-480 kJ/mol	1112:1125	402-480 kJ/mol	1112:1125	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	5	51	theme	activation	1042:1051	arg1	energies					1053:1060	the activation energies	1038:1060	the activation energies of junction zone dissociation	1038:1090	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	5	52	theme	zone	1074:1077	arg1	dissociation					1079:1090	junction zone dissociation	1065:1090	junction zone dissociation	1065:1090	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	5	53	theme	storage	933:939	arg1	modulus					941:947	storage modulus	933:947	storage modulus	933:947	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	3	54	theme	shear	495:499	arg1	rheology					501:508	Small and large amplitude oscillatory shear rheology	457:508	Small and large amplitude oscillatory shear rheology	457:508	Small and large amplitude oscillatory shear rheology is used to characterise the sol-gel transition as a function of temperature and concentration.
34294330	1	55	theme	seed	266:269	arg1	mucilage					271:278	seed mucilage	266:278	Plantago ovata seed mucilage	251:278	We report rheological characterisation of hydrogels formed by highly substituted brush-like arabinoxylans from Plantago ovata seed mucilage.
34294330	5	56	theme	junction	1171:1178	arg1	types					1180:1184	the 'slow' and 'fast' junction types	1149:1184	the 'slow' and 'fast' junction types	1149:1184	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	5	57	theme	dissociation	1079:1090	arg1	402-480 kJ/mol					1112:1125	402-480 kJ/mol	1112:1125	402-480 kJ/mol	1112:1125	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	5	57	theme	dissociation	1079:1090	arg1	energies					1053:1060	the activation energies	1038:1060	the activation energies of junction zone dissociation	1038:1090	Based on the temperature dependence of storage modulus and time-temperature superposition principle in combination with the Arrhenius equation, the activation energies of junction zone dissociation are estimated to be 402-480 kJ/mol and 97-144 kJ/mol for the 'slow' and 'fast' junction types, respectively.
34294330	2	58	theme	rheological	401:411	arg1	properties					413:422	distinct rheological properties	392:422	distinct rheological properties	392:422	Two arabinoxlyan fractions with similar molecular weight and linkage compositions are chosen to form gels with distinct rheological properties but a similar network structure.
34778959	7	0	theme	microbial	1124:1132	arg1	diversity					1134:1142	the microbial diversity	1120:1142	the microbial diversity	1120:1142	Through the analysis of high-throughput sequencing (HTS), the microbial diversity was changed respectively.
34778959	7	1	theme	high-throughput	1086:1100	arg1	HTS					1114:1116	HTS	1114:1116	HTS	1114:1116	Through the analysis of high-throughput sequencing (HTS), the microbial diversity was changed respectively.
34778959	7	1	theme	high-throughput	1086:1100	arg1	sequencing					1102:1111	high-throughput sequencing	1086:1111	high-throughput sequencing (HTS)	1086:1117	Through the analysis of high-throughput sequencing (HTS), the microbial diversity was changed respectively.
34778959	10	2	dep	combined	1529:1536	arg1	CONCLUSIONS					1514:1524	CONCLUSIONS	1514:1524	CONCLUSIONS CS combined with AP coating	1514:1552	CONCLUSIONS CS combined with AP coating may be considered a promising method to delay the biochemical changes of ice stored large yellow croaker and extend its shelf life.
34778959	10	2	dep	combined	1529:1536	arg1	CS					1526:1527	CS	1526:1527	CS	1526:1527	CONCLUSIONS CS combined with AP coating may be considered a promising method to delay the biochemical changes of ice stored large yellow croaker and extend its shelf life.
34778959	4	3	theme	1.0 g L-1	658:666	arg1	coating					671:677	1.0 g L-1 AP coating	658:677	1.0 g L-1 AP coating	658:677	The effects of 10.0 and 20.0 g L-1 CS combined with 1.0 g L-1 AP coating on the quality and microbial composition of large yellow croaker during ice storage were investigated respectively.
34778959	9	4	theme	yellow	1479:1484	arg1	croaker					1486:1492	large yellow croaker	1473:1492	large yellow croaker	1473:1492	Compared with the shelf-life of the control group (8 days), 20.0 g L-1 CS combined with 1.0 g L-1 AP coating treatment could extend the shelf-life of large yellow croaker for another 8 days.
34778959	0	5	theme	microbial	64:72	arg1	composition					74:84	microbial composition	64:84	microbial composition	64:84	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	10	6	theme	ice	1627:1629	arg1	croaker					1651:1657	ice stored large yellow croaker	1627:1657	ice stored large yellow croaker	1627:1657	CONCLUSIONS CS combined with AP coating may be considered a promising method to delay the biochemical changes of ice stored large yellow croaker and extend its shelf life.
34778959	7	7	theme	sequencing	1102:1111	arg1	analysis					1074:1081	the analysis	1070:1081	the analysis of high-throughput sequencing (HTS)	1070:1117	Through the analysis of high-throughput sequencing (HTS), the microbial diversity was changed respectively.
34778959	8	8	theme	Shewanella	1188:1197	arg1	proportion					1174:1183	The proportion	1170:1183	The proportion of Shewanella	1170:1197	The proportion of Shewanella was significantly decreased by CS + AP coating treatment and Pseudomonas was the dominant microorganism in spoiled samples.
34778959	5	9	theme	TVB-N	877:881	arg1	increase					834:841	the increase	830:841	the increase of total volatile basic nitrogen (TVB-N) and biogenic amines	830:902	RESULTS CS + AP coating restrained the increase of total volatile basic nitrogen (TVB-N) and biogenic amines, slowed down the rise of K-value and retarded the growth of microorganisms.
34778959	10	10	theme	AP	1543:1544	arg1	coating					1546:1552	AP coating	1543:1552	AP coating	1543:1552	CONCLUSIONS CS combined with AP coating may be considered a promising method to delay the biochemical changes of ice stored large yellow croaker and extend its shelf life.
34778959	0	11	theme	large	89:93	arg1	crocea					125:130	Pseudosciaena crocea	111:130	Pseudosciaena crocea	111:130	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	0	11	theme	large	89:93	arg1	croaker					102:108	large yellow croaker	89:108	large yellow croaker (Pseudosciaena crocea) during ice storage	89:150	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	0	12	from	Effects	0:6	arg1	quality					52:58	quality	52:58	quality	52:58	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	0	12	from	Effects	0:6	arg1	composition					74:84	microbial composition	64:84	microbial composition	64:84	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	4	13	theme	large	723:727	arg1	croaker					736:742	large yellow croaker	723:742	large yellow croaker during ice storage	723:761	The effects of 10.0 and 20.0 g L-1 CS combined with 1.0 g L-1 AP coating on the quality and microbial composition of large yellow croaker during ice storage were investigated respectively.
34778959	10	14	theme	stored	1631:1636	arg1	croaker					1651:1657	ice stored large yellow croaker	1627:1657	ice stored large yellow croaker	1627:1657	CONCLUSIONS CS combined with AP coating may be considered a promising method to delay the biochemical changes of ice stored large yellow croaker and extend its shelf life.
34778959	9	15	theme	croaker	1486:1492	arg1	shelf-life					1459:1468	the shelf-life	1455:1468	the shelf-life of large yellow croaker for another 8 days	1455:1511	Compared with the shelf-life of the control group (8 days), 20.0 g L-1 CS combined with 1.0 g L-1 AP coating treatment could extend the shelf-life of large yellow croaker for another 8 days.
34778959	1	16	theme	high	254:257	arg1	value					271:275	its high nutritional value	250:275	its high nutritional value	250:275	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	0	17	theme	croaker	102:108	arg1	quality					52:58	quality	52:58	quality	52:58	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	0	17	theme	croaker	102:108	arg1	composition					74:84	microbial composition	64:84	microbial composition	64:84	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	4	18	dep	quality	686:692	arg1	the					682:684	the	682:684	the	682:684	The effects of 10.0 and 20.0 g L-1 CS combined with 1.0 g L-1 AP coating on the quality and microbial composition of large yellow croaker during ice storage were investigated respectively.
34778959	8	19	theme	coating	1238:1244	arg1	treatment					1246:1254	CS + AP coating treatment	1230:1254	CS + AP coating treatment	1230:1254	The proportion of Shewanella was significantly decreased by CS + AP coating treatment and Pseudomonas was the dominant microorganism in spoiled samples.
34778959	4	20	theme	croaker	736:742	arg1	quality					686:692	quality	686:692	quality	686:692	The effects of 10.0 and 20.0 g L-1 CS combined with 1.0 g L-1 AP coating on the quality and microbial composition of large yellow croaker during ice storage were investigated respectively.
34778959	4	20	theme	croaker	736:742	arg1	composition					708:718	microbial composition	698:718	microbial composition	698:718	The effects of 10.0 and 20.0 g L-1 CS combined with 1.0 g L-1 AP coating on the quality and microbial composition of large yellow croaker during ice storage were investigated respectively.
34778959	5	21	theme	total	846:850	arg1	TVB-N					877:881	total volatile basic nitrogen (TVB-N) and biogenic amines	846:902	TVB-N	877:881	RESULTS CS + AP coating restrained the increase of total volatile basic nitrogen (TVB-N) and biogenic amines, slowed down the rise of K-value and retarded the growth of microorganisms.
34778959	1	22	theme	BACKGROUND	153:162	arg1	croaker					177:183	BACKGROUND Large yellow croaker	153:183	BACKGROUND Large yellow croaker (Pseudosciaena crocea)	153:206	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	1	22	theme	BACKGROUND	153:162	arg1	crocea					200:205	Pseudosciaena crocea	186:205	Pseudosciaena crocea	186:205	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	0	23	theme	yellow	95:100	arg1	crocea					125:130	Pseudosciaena crocea	111:130	Pseudosciaena crocea	111:130	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	0	23	theme	yellow	95:100	arg1	croaker					102:108	large yellow croaker	89:108	large yellow croaker (Pseudosciaena crocea) during ice storage	89:150	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	8	24	theme	spoiled	1306:1312	arg1	samples					1314:1320	spoiled samples	1306:1320	spoiled samples	1306:1320	The proportion of Shewanella was significantly decreased by CS + AP coating treatment and Pseudomonas was the dominant microorganism in spoiled samples.
34778959	9	25	theme	20.0 g L-1	1383:1392	arg1	CS					1394:1395	20.0 g L-1 CS	1383:1395	20.0 g L-1 CS combined with 1.0 g L-1 AP coating treatment	1383:1440	Compared with the shelf-life of the control group (8 days), 20.0 g L-1 CS combined with 1.0 g L-1 AP coating treatment could extend the shelf-life of large yellow croaker for another 8 days.
34778959	4	26	theme	yellow	729:734	arg1	croaker					736:742	large yellow croaker	723:742	large yellow croaker during ice storage	723:761	The effects of 10.0 and 20.0 g L-1 CS combined with 1.0 g L-1 AP coating on the quality and microbial composition of large yellow croaker during ice storage were investigated respectively.
34778959	6	27	theme	CS	1058:1059	arg1	concentration					1041:1053	the concentration	1037:1053	the concentration of CS	1037:1059	The bacteriostatic effect was positively correlated with the concentration of CS.
34778959	1	28	theme	Large	164:168	arg1	croaker					177:183	BACKGROUND Large yellow croaker	153:183	BACKGROUND Large yellow croaker (Pseudosciaena crocea)	153:206	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	1	28	theme	Large	164:168	arg1	crocea					200:205	Pseudosciaena crocea	186:205	Pseudosciaena crocea	186:205	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	1	29	theme	yellow	170:175	arg1	croaker					177:183	BACKGROUND Large yellow croaker	153:183	BACKGROUND Large yellow croaker (Pseudosciaena crocea)	153:206	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	1	29	theme	yellow	170:175	arg1	crocea					200:205	Pseudosciaena crocea	186:205	Pseudosciaena crocea	186:205	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	10	30	theme	promising	1574:1582	arg1	method					1584:1589	a promising method	1572:1589	a promising method to delay the biochemical changes of ice stored large yellow croaker and extend its shelf life	1572:1683	CONCLUSIONS CS combined with AP coating may be considered a promising method to delay the biochemical changes of ice stored large yellow croaker and extend its shelf life.
34778959	1	31	theme	nutritional	259:269	arg1	value					271:275	its high nutritional value	250:275	its high nutritional value	250:275	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	4	32	from	effects	610:616	arg1	quality					686:692	quality	686:692	quality	686:692	The effects of 10.0 and 20.0 g L-1 CS combined with 1.0 g L-1 AP coating on the quality and microbial composition of large yellow croaker during ice storage were investigated respectively.
34778959	4	32	from	effects	610:616	arg1	composition					708:718	microbial composition	698:718	microbial composition	698:718	The effects of 10.0 and 20.0 g L-1 CS combined with 1.0 g L-1 AP coating on the quality and microbial composition of large yellow croaker during ice storage were investigated respectively.
34778959	5	33	theme	volatile	852:859	arg1	TVB-N					877:881	total volatile basic nitrogen (TVB-N) and biogenic amines	846:902	TVB-N	877:881	RESULTS CS + AP coating restrained the increase of total volatile basic nitrogen (TVB-N) and biogenic amines, slowed down the rise of K-value and retarded the growth of microorganisms.
34778959	2	34	theme	tissue	420:425	arg1	corruption					399:408	the corruption	395:408	the corruption of muscle tissue	395:425	However, large yellow croaker is readily affected by microorganisms during storage, which causes the corruption of muscle tissue.
34778959	0	35	theme	Pseudosciaena	111:123	arg1	crocea					125:130	Pseudosciaena crocea	111:130	Pseudosciaena crocea	111:130	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	0	35	theme	Pseudosciaena	111:123	arg1	croaker					102:108	large yellow croaker	89:108	large yellow croaker (Pseudosciaena crocea) during ice storage	89:150	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	5	36	theme	amines	897:902	arg1	increase					834:841	the increase	830:841	the increase of total volatile basic nitrogen (TVB-N) and biogenic amines	830:902	RESULTS CS + AP coating restrained the increase of total volatile basic nitrogen (TVB-N) and biogenic amines, slowed down the rise of K-value and retarded the growth of microorganisms.
34778959	8	37	from	microorganism	1289:1301	arg1	samples					1314:1320	spoiled samples	1306:1320	spoiled samples	1306:1320	The proportion of Shewanella was significantly decreased by CS + AP coating treatment and Pseudomonas was the dominant microorganism in spoiled samples.
34778959	10	38	theme	large	1638:1642	arg1	croaker					1651:1657	ice stored large yellow croaker	1627:1657	ice stored large yellow croaker	1627:1657	CONCLUSIONS CS combined with AP coating may be considered a promising method to delay the biochemical changes of ice stored large yellow croaker and extend its shelf life.
34778959	0	39	theme	chitosan	11:18	arg1	coating					41:47	chitosan and apple polyphenol coating	11:47	chitosan and apple polyphenol coating	11:47	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	5	40	theme	K-value	929:935	arg1	rise					921:924	the rise	917:924	the rise of K-value	917:935	RESULTS CS + AP coating restrained the increase of total volatile basic nitrogen (TVB-N) and biogenic amines, slowed down the rise of K-value and retarded the growth of microorganisms.
34778959	4	41	theme	microbial	698:706	arg1	composition					708:718	microbial composition	698:718	microbial composition	698:718	The effects of 10.0 and 20.0 g L-1 CS combined with 1.0 g L-1 AP coating on the quality and microbial composition of large yellow croaker during ice storage were investigated respectively.
34778959	1	42	theme	Pseudosciaena	186:198	arg1	croaker					177:183	BACKGROUND Large yellow croaker	153:183	BACKGROUND Large yellow croaker (Pseudosciaena crocea)	153:206	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	1	42	theme	Pseudosciaena	186:198	arg1	crocea					200:205	Pseudosciaena crocea	186:205	Pseudosciaena crocea	186:205	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	0	43	theme	polyphenol	30:39	arg1	coating					41:47	chitosan and apple polyphenol coating	11:47	chitosan and apple polyphenol coating	11:47	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	1	44	theme	delicious	281:289	arg1	taste					291:295	delicious taste	281:295	delicious taste	281:295	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	9	45	theme	large	1473:1477	arg1	croaker					1486:1492	large yellow croaker	1473:1492	large yellow croaker	1473:1492	Compared with the shelf-life of the control group (8 days), 20.0 g L-1 CS combined with 1.0 g L-1 AP coating treatment could extend the shelf-life of large yellow croaker for another 8 days.
34778959	5	46	theme	microorganisms	964:977	arg1	growth					954:959	the growth	950:959	the growth of microorganisms	950:977	RESULTS CS + AP coating restrained the increase of total volatile basic nitrogen (TVB-N) and biogenic amines, slowed down the rise of K-value and retarded the growth of microorganisms.
34778959	10	47	theme	yellow	1644:1649	arg1	croaker					1651:1657	ice stored large yellow croaker	1627:1657	ice stored large yellow croaker	1627:1657	CONCLUSIONS CS combined with AP coating may be considered a promising method to delay the biochemical changes of ice stored large yellow croaker and extend its shelf life.
34778959	0	48	theme	apple	24:28	arg1	coating					41:47	chitosan and apple polyphenol coating	11:47	chitosan and apple polyphenol coating	11:47	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	10	49	theme	croaker	1651:1657	arg1	changes					1616:1622	the biochemical changes	1600:1622	the biochemical changes of ice stored large yellow croaker	1600:1657	CONCLUSIONS CS combined with AP coating may be considered a promising method to delay the biochemical changes of ice stored large yellow croaker and extend its shelf life.
34778959	9	50	theme	group	1367:1371	arg1	shelf-life					1341:1350	the shelf-life	1337:1350	the shelf-life of the control group (8 days)	1337:1380	Compared with the shelf-life of the control group (8 days), 20.0 g L-1 CS combined with 1.0 g L-1 AP coating treatment could extend the shelf-life of large yellow croaker for another 8 days.
34778959	3	51	theme	croaker	597:603	arg1	quality					573:579	the quality	569:579	the quality of large yellow croaker	569:603	Both chitosan (CS) and apple polyphenols (APs) are bio-preservatives, which can effectively inhibit the growth of microorganisms and improve the quality of large yellow croaker.
34778959	8	52	theme	dominant	1280:1287	arg1	microorganism					1289:1301	the dominant microorganism	1276:1301	the dominant microorganism in spoiled samples	1276:1320	The proportion of Shewanella was significantly decreased by CS + AP coating treatment and Pseudomonas was the dominant microorganism in spoiled samples.
34778959	8	52	theme	dominant	1280:1287	arg1	Pseudomonas					1260:1270	Pseudomonas	1260:1270	Pseudomonas	1260:1270	The proportion of Shewanella was significantly decreased by CS + AP coating treatment and Pseudomonas was the dominant microorganism in spoiled samples.
34778959	5	53	theme	basic	861:865	arg1	TVB-N					877:881	total volatile basic nitrogen (TVB-N) and biogenic amines	846:902	TVB-N	877:881	RESULTS CS + AP coating restrained the increase of total volatile basic nitrogen (TVB-N) and biogenic amines, slowed down the rise of K-value and retarded the growth of microorganisms.
34778959	0	54	theme	ice	140:142	arg1	storage					144:150	ice storage	140:150	ice storage	140:150	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	3	55	theme	microorganisms	542:555	arg1	growth					532:537	the growth	528:537	the growth of microorganisms	528:555	Both chitosan (CS) and apple polyphenols (APs) are bio-preservatives, which can effectively inhibit the growth of microorganisms and improve the quality of large yellow croaker.
34778959	9	56	theme	1.0 g L-1	1411:1419	arg1	AP					1421:1422	1.0 g L-1 AP	1411:1422	1.0 g L-1 AP coating treatment	1411:1440	Compared with the shelf-life of the control group (8 days), 20.0 g L-1 CS combined with 1.0 g L-1 AP coating treatment could extend the shelf-life of large yellow croaker for another 8 days.
34778959	0	57	theme	coating	41:47	arg1	Effects					0:6	Effects	0:6	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.	0:151	Effects of chitosan and apple polyphenol coating on quality and microbial composition of large yellow croaker (Pseudosciaena crocea) during ice storage.
34778959	9	58	theme	control	1359:1365	arg1	8 days					1374:1379	8 days	1374:1379	8 days	1374:1379	Compared with the shelf-life of the control group (8 days), 20.0 g L-1 CS combined with 1.0 g L-1 AP coating treatment could extend the shelf-life of large yellow croaker for another 8 days.
34778959	9	58	theme	control	1359:1365	arg1	group					1367:1371	the control group	1355:1371	the control group (8 days)	1355:1380	Compared with the shelf-life of the control group (8 days), 20.0 g L-1 CS combined with 1.0 g L-1 AP coating treatment could extend the shelf-life of large yellow croaker for another 8 days.
34778959	1	59	contain	has	208:210	arg1	crocea					200:205	Pseudosciaena crocea	186:205	Pseudosciaena crocea	186:205	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	1	59	contain	has	208:210	arg1	croaker					177:183	BACKGROUND Large yellow croaker	153:183	BACKGROUND Large yellow croaker (Pseudosciaena crocea)	153:206	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	1	59	contain	has	208:210	arg2	value					233:237	important commercial value	212:237	important commercial value	212:237	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	4	60	theme	AP	668:669	arg1	coating					671:677	1.0 g L-1 AP coating	658:677	1.0 g L-1 AP coating	658:677	The effects of 10.0 and 20.0 g L-1 CS combined with 1.0 g L-1 AP coating on the quality and microbial composition of large yellow croaker during ice storage were investigated respectively.
34778959	5	61	dep	coating	811:817	arg1	restrained					819:828	restrained	819:828	restrained the increase of total volatile basic nitrogen (TVB-N) and biogenic amines	819:902	RESULTS CS + AP coating restrained the increase of total volatile basic nitrogen (TVB-N) and biogenic amines, slowed down the rise of K-value and retarded the growth of microorganisms.
34778959	5	61	dep	coating	811:817	arg1	retarded					941:948	retarded	941:948	retarded the growth of microorganisms	941:977	RESULTS CS + AP coating restrained the increase of total volatile basic nitrogen (TVB-N) and biogenic amines, slowed down the rise of K-value and retarded the growth of microorganisms.
34778959	5	61	dep	coating	811:817	arg1	slowed					905:910	slowed	905:910	slowed down the rise of K-value	905:935	RESULTS CS + AP coating restrained the increase of total volatile basic nitrogen (TVB-N) and biogenic amines, slowed down the rise of K-value and retarded the growth of microorganisms.
34778959	10	62	theme	biochemical	1604:1614	arg1	changes					1616:1622	the biochemical changes	1600:1622	the biochemical changes of ice stored large yellow croaker	1600:1657	CONCLUSIONS CS combined with AP coating may be considered a promising method to delay the biochemical changes of ice stored large yellow croaker and extend its shelf life.
34778959	4	63	theme	ice	751:753	arg1	storage					755:761	ice storage	751:761	ice storage	751:761	The effects of 10.0 and 20.0 g L-1 CS combined with 1.0 g L-1 AP coating on the quality and microbial composition of large yellow croaker during ice storage were investigated respectively.
34778959	3	64	theme	large	584:588	arg1	croaker					597:603	large yellow croaker	584:603	large yellow croaker	584:603	Both chitosan (CS) and apple polyphenols (APs) are bio-preservatives, which can effectively inhibit the growth of microorganisms and improve the quality of large yellow croaker.
34778959	8	65	theme	CS + AP	1230:1236	arg1	treatment					1246:1254	CS + AP coating treatment	1230:1254	CS + AP coating treatment	1230:1254	The proportion of Shewanella was significantly decreased by CS + AP coating treatment and Pseudomonas was the dominant microorganism in spoiled samples.
34778959	2	66	theme	yellow	313:318	arg1	croaker					320:326	large yellow croaker	307:326	large yellow croaker	307:326	However, large yellow croaker is readily affected by microorganisms during storage, which causes the corruption of muscle tissue.
34778959	6	67	theme	bacteriostatic	984:997	arg1	effect					999:1004	The bacteriostatic effect	980:1004	The bacteriostatic effect	980:1004	The bacteriostatic effect was positively correlated with the concentration of CS.
34778959	5	68	theme	biogenic	888:895	arg1	amines					897:902	total volatile basic nitrogen (TVB-N) and biogenic amines	846:902	amines	897:902	RESULTS CS + AP coating restrained the increase of total volatile basic nitrogen (TVB-N) and biogenic amines, slowed down the rise of K-value and retarded the growth of microorganisms.
34778959	3	69	theme	yellow	590:595	arg1	croaker					597:603	large yellow croaker	584:603	large yellow croaker	584:603	Both chitosan (CS) and apple polyphenols (APs) are bio-preservatives, which can effectively inhibit the growth of microorganisms and improve the quality of large yellow croaker.
34778959	2	70	theme	large	307:311	arg1	croaker					320:326	large yellow croaker	307:326	large yellow croaker	307:326	However, large yellow croaker is readily affected by microorganisms during storage, which causes the corruption of muscle tissue.
34778959	1	71	theme	important	212:220	arg1	value					233:237	important commercial value	212:237	important commercial value	212:237	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	10	72	theme	shelf	1674:1678	arg1	life					1680:1683	its shelf life	1670:1683	its shelf life	1670:1683	CONCLUSIONS CS combined with AP coating may be considered a promising method to delay the biochemical changes of ice stored large yellow croaker and extend its shelf life.
34778959	5	73	theme	nitrogen	867:874	arg1	TVB-N					877:881	total volatile basic nitrogen (TVB-N) and biogenic amines	846:902	TVB-N	877:881	RESULTS CS + AP coating restrained the increase of total volatile basic nitrogen (TVB-N) and biogenic amines, slowed down the rise of K-value and retarded the growth of microorganisms.
34778959	3	74	theme	apple	451:455	arg1	polyphenols					457:467	apple polyphenols	451:467	apple polyphenols (APs)	451:473	Both chitosan (CS) and apple polyphenols (APs) are bio-preservatives, which can effectively inhibit the growth of microorganisms and improve the quality of large yellow croaker.
34778959	3	74	theme	apple	451:455	arg1	chitosan					433:440	chitosan	433:440	chitosan (CS)	433:445	Both chitosan (CS) and apple polyphenols (APs) are bio-preservatives, which can effectively inhibit the growth of microorganisms and improve the quality of large yellow croaker.
34778959	3	74	theme	apple	451:455	arg1	APs					470:472	APs	470:472	APs	470:472	Both chitosan (CS) and apple polyphenols (APs) are bio-preservatives, which can effectively inhibit the growth of microorganisms and improve the quality of large yellow croaker.
34778959	3	74	theme	apple	451:455	arg1	bio-preservatives					479:495	bio-preservatives	479:495	bio-preservatives	479:495	Both chitosan (CS) and apple polyphenols (APs) are bio-preservatives, which can effectively inhibit the growth of microorganisms and improve the quality of large yellow croaker.
34778959	1	75	theme	commercial	222:231	arg1	value					233:237	important commercial value	212:237	important commercial value	212:237	BACKGROUND Large yellow croaker (Pseudosciaena crocea) has important commercial value because of its high nutritional value and delicious taste.
34778959	2	76	theme	muscle	413:418	arg1	tissue					420:425	muscle tissue	413:425	muscle tissue	413:425	However, large yellow croaker is readily affected by microorganisms during storage, which causes the corruption of muscle tissue.
34778959	4	77	theme	CS	641:642	arg1	effects					610:616	The effects	606:616	The effects of 10.0 and 20.0 g L-1 CS combined with 1.0 g L-1 AP coating on the quality and microbial composition of large yellow croaker during ice storage	606:761	The effects of 10.0 and 20.0 g L-1 CS combined with 1.0 g L-1 AP coating on the quality and microbial composition of large yellow croaker during ice storage were investigated respectively.
34778959	11	78	theme	Chemical	1704:1711	arg1	Industry					1713:1720	Chemical Industry	1704:1720	Chemical Industry	1704:1720	© 2021 Society of Chemical Industry.
32032761	7	0	theme	notable	1226:1232	arg1	activity					1234:1241	notable activity	1226:1241	notable activity of the different extracts	1226:1267	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	0	1	theme	leucocyte	118:126	arg1	activities					128:137	leucocyte activities	118:137	leucocyte activities	118:137	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	5	2	dep	leucocytes	795:804	arg1	activities					853:862	viability, phagocytosis and respiratory burst activities	807:862	viability, phagocytosis and respiratory burst activities	807:862	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	5	2	dep	leucocytes	795:804	arg1	content					879:885	peroxidase content	868:885	peroxidase content	868:885	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	10	3	from	important	1673:1681	arg1	terms					1686:1690	terms	1686:1690	terms of any positive results	1686:1714	The concentration and nature of the extracts were very important in terms of any positive results.
32032761	7	4	theme	bactericidal	1089:1100	arg1	activity					1102:1109	the bactericidal activity	1085:1109	the bactericidal activity	1085:1109	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	6	5	from	effect	1056:1061	arg1	PLHC-1 cells					1066:1077	PLHC-1 cells	1066:1077	PLHC-1 cells	1066:1077	Furthermore, the ethanolic extracts used at 0.5, 0.75 and 1 mg mL-1 and aqueous extracts at 1 g mL-1 had a cytotoxic effect on PLHC-1 cells.
32032761	3	6	theme	antibacterial	513:525	arg1	activities					527:536	immunostimulant and antibacterial activities	493:536	immunostimulant and antibacterial activities	493:536	Aqueous and ethanolic extracts obtained from carob leaves were characterized in terms of biochemical composition, antiradical and cytotoxic effects and immunostimulant and antibacterial activities.
32032761	9	7	used	used	1555:1558	arg2	alternative					1566:1576	an alternative	1563:1576	an alternative to chemical compounds with farmed fish	1563:1615	This work demonstrates interesting in vitro effects of carob leaf extracts and suggests it could be used as an alternative to chemical compounds with farmed fish.
32032761	9	7	used	used	1555:1558	arg2	it					1543:1544	it	1543:1544	it	1543:1544	This work demonstrates interesting in vitro effects of carob leaf extracts and suggests it could be used as an alternative to chemical compounds with farmed fish.
32032761	4	8	theme	higher	639:644	arg1	activity					658:665	higher antioxidant activity	639:665	higher antioxidant activity	639:665	The ethanolic extract showed higher levels of total phenolics, flavonoids and condensed tannins and higher antioxidant activity than the aqueous extract.
32032761	3	9	theme	immunostimulant	493:507	arg1	activities					527:536	immunostimulant and antibacterial activities	493:536	immunostimulant and antibacterial activities	493:536	Aqueous and ethanolic extracts obtained from carob leaves were characterized in terms of biochemical composition, antiradical and cytotoxic effects and immunostimulant and antibacterial activities.
32032761	6	10	from	mL-1	1035:1038	arg1	extracts					966:973	the ethanolic extracts	952:973	the ethanolic extracts used at 0.5, 0.75 and 1 mg mL-1	952:1005	Furthermore, the ethanolic extracts used at 0.5, 0.75 and 1 mg mL-1 and aqueous extracts at 1 g mL-1 had a cytotoxic effect on PLHC-1 cells.
32032761	6	10	from	mL-1	1035:1038	arg1	extracts					1019:1026	aqueous extracts	1011:1026	aqueous extracts at 1 g mL-1	1011:1038	Furthermore, the ethanolic extracts used at 0.5, 0.75 and 1 mg mL-1 and aqueous extracts at 1 g mL-1 had a cytotoxic effect on PLHC-1 cells.
32032761	1	11	theme	Antioxidant	140:150	arg1	properties					180:189	Antioxidant, cytotoxic and bactericidal properties	140:189	Antioxidant, cytotoxic and bactericidal properties	140:189	Antioxidant, cytotoxic and bactericidal properties.
32032761	1	12	theme	cytotoxic	153:161	arg1	properties					180:189	Antioxidant, cytotoxic and bactericidal properties	140:189	Antioxidant, cytotoxic and bactericidal properties	140:189	Antioxidant, cytotoxic and bactericidal properties.
32032761	6	13	theme	ethanolic	956:964	arg1	extracts					966:973	the ethanolic extracts	952:973	the ethanolic extracts used at 0.5, 0.75 and 1 mg mL-1	952:1005	Furthermore, the ethanolic extracts used at 0.5, 0.75 and 1 mg mL-1 and aqueous extracts at 1 g mL-1 had a cytotoxic effect on PLHC-1 cells.
32032761	4	14	theme	tannins	627:633	arg1	levels					575:580	higher levels	568:580	higher levels of total phenolics, flavonoids and condensed tannins	568:633	The ethanolic extract showed higher levels of total phenolics, flavonoids and condensed tannins and higher antioxidant activity than the aqueous extract.
32032761	4	14	theme	tannins	627:633	arg1	activity					658:665	higher antioxidant activity	639:665	higher antioxidant activity	639:665	The ethanolic extract showed higher levels of total phenolics, flavonoids and condensed tannins and higher antioxidant activity than the aqueous extract.
32032761	5	15	theme	immunostimulant	708:722	arg1	effects					724:730	No significant immunostimulant effects	693:730	No significant immunostimulant effects	693:730	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	7	16	theme	pathogenic	1141:1150	arg1	bacteria					1152:1159	three fish pathogenic bacteria	1130:1159	three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae)	1130:1224	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	7	16	theme	pathogenic	1141:1150	arg1	harveyi					1169:1175	Vibrio harveyi	1162:1175	Vibrio harveyi	1162:1175	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	7	16	theme	pathogenic	1141:1150	arg1	anguillarum					1185:1195	Vibrio anguillarum	1178:1195	Vibrio anguillarum	1178:1195	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	7	16	theme	pathogenic	1141:1150	arg1	damselae					1216:1223	Photobacterium damselae	1201:1223	Photobacterium damselae	1201:1223	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	5	17	theme	burst	847:851	arg1	activities					853:862	viability, phagocytosis and respiratory burst activities	807:862	viability, phagocytosis and respiratory burst activities	807:862	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	8	18	theme	concentrations	1439:1452	arg1	range					1430:1434	the same range	1421:1434	the same range of concentrations	1421:1452	A similar effect was demonstrated against V. haryeri when ethanolic extracts were used in the same range of concentrations.
32032761	2	19	dep	Carob	192:196	arg1	leaves					198:203	leaves	198:203	leaves	198:203	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	0	20	theme	Sparus	100:105	arg1	aurata					107:112	Sparus aurata L.	100:115	Sparus aurata L.	100:115	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	0	20	theme	Sparus	100:105	arg1	study					12:16	An in vitro study	0:16	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.)	0:116	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	2	21	theme	main	210:213	arg1	Carob					192:196	Carob	192:196	Carob leaves	192:203	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	2	21	theme	main	210:213	arg1	tree					237:240	the carob tree	227:240	the carob tree	227:240	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	2	21	theme	main	210:213	arg1	residues					215:222	the main residues	206:222	the main residues of the carob tree	206:240	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	6	22	theme	aqueous	1011:1017	arg1	extracts					1019:1026	aqueous extracts	1011:1026	aqueous extracts at 1 g mL-1	1011:1038	Furthermore, the ethanolic extracts used at 0.5, 0.75 and 1 mg mL-1 and aqueous extracts at 1 g mL-1 had a cytotoxic effect on PLHC-1 cells.
32032761	9	23	theme	interesting	1478:1488	arg1	effects					1499:1505	interesting in vitro effects	1478:1505	interesting in vitro effects of carob leaf extracts	1478:1528	This work demonstrates interesting in vitro effects of carob leaf extracts and suggests it could be used as an alternative to chemical compounds with farmed fish.
32032761	0	24	theme	carob	35:39	arg1	extracts					69:76	carob (Ceratonia siliqua L.) leaf extracts	35:76	carob (Ceratonia siliqua L.) leaf extracts	35:76	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	9	25	theme	leaf	1516:1519	arg1	extracts					1521:1528	carob leaf extracts	1510:1528	carob leaf extracts	1510:1528	This work demonstrates interesting in vitro effects of carob leaf extracts and suggests it could be used as an alternative to chemical compounds with farmed fish.
32032761	5	26	with	incubation	894:903	arg1	extracts					929:936	different extracts	919:936	different extracts	919:936	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	5	27	theme	Sparus	768:773	arg1	seabream					758:765	gilthead seabream	749:765	gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content)	749:886	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	5	27	theme	Sparus	768:773	arg1	aurata					775:780	Sparus aurata	768:780	Sparus aurata	768:780	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	8	28	theme	similar	1333:1339	arg1	effect					1341:1346	A similar effect	1331:1346	A similar effect	1331:1346	A similar effect was demonstrated against V. haryeri when ethanolic extracts were used in the same range of concentrations.
32032761	7	29	located	detected	1273:1280	arg1	concentrations					1315:1328	all three concentrations	1305:1328	all three concentrations	1305:1328	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	7	29	located	detected	1273:1280	arg2	activity					1234:1241	notable activity	1226:1241	notable activity of the different extracts	1226:1267	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	2	30	theme	carob	231:235	arg1	tree					237:240	the carob tree	227:240	the carob tree	227:240	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	0	31	from	effect	25:30	arg1	seabream					90:97	gilthead seabream	81:97	gilthead seabream	81:97	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	9	32	dep	in	1490:1491	arg1	vitro					1493:1497	vitro	1493:1497	vitro	1493:1497	This work demonstrates interesting in vitro effects of carob leaf extracts and suggests it could be used as an alternative to chemical compounds with farmed fish.
32032761	0	33	theme	leaf	64:67	arg1	extracts					69:76	carob (Ceratonia siliqua L.) leaf extracts	35:76	carob (Ceratonia siliqua L.) leaf extracts	35:76	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	6	34	theme	cytotoxic	1046:1054	arg1	effect					1056:1061	a cytotoxic effect	1044:1061	a cytotoxic effect on PLHC-1 cells	1044:1077	Furthermore, the ethanolic extracts used at 0.5, 0.75 and 1 mg mL-1 and aqueous extracts at 1 g mL-1 had a cytotoxic effect on PLHC-1 cells.
32032761	2	35	theme	fish	323:326	arg1	aquaculture					328:338	fish aquaculture	323:338	fish aquaculture	323:338	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	7	36	theme	Vibrio	1162:1167	arg1	bacteria					1152:1159	three fish pathogenic bacteria	1130:1159	three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae)	1130:1224	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	7	36	theme	Vibrio	1162:1167	arg1	harveyi					1169:1175	Vibrio harveyi	1162:1175	Vibrio harveyi	1162:1175	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	10	37	from	terms	1686:1690	arg1	important					1673:1681	important	1673:1681	important	1673:1681	The concentration and nature of the extracts were very important in terms of any positive results.
32032761	6	38	theme	g	1033:1033	arg1	mL-1					1035:1038	1 g mL-1	1031:1038	1 g mL-1	1031:1038	Furthermore, the ethanolic extracts used at 0.5, 0.75 and 1 mg mL-1 and aqueous extracts at 1 g mL-1 had a cytotoxic effect on PLHC-1 cells.
32032761	3	39	theme	ethanolic	353:361	arg1	extracts					363:370	Aqueous and ethanolic extracts	341:370	Aqueous and ethanolic extracts obtained from carob	341:390	Aqueous and ethanolic extracts obtained from carob leaves were characterized in terms of biochemical composition, antiradical and cytotoxic effects and immunostimulant and antibacterial activities.
32032761	8	40	theme	ethanolic	1389:1397	arg1	extracts					1399:1406	ethanolic extracts	1389:1406	ethanolic extracts	1389:1406	A similar effect was demonstrated against V. haryeri when ethanolic extracts were used in the same range of concentrations.
32032761	10	41	theme	extracts	1654:1661	arg1	nature					1640:1645	nature	1640:1645	nature	1640:1645	The concentration and nature of the extracts were very important in terms of any positive results.
32032761	10	41	theme	extracts	1654:1661	arg1	concentration					1622:1634	concentration	1622:1634	concentration	1622:1634	The concentration and nature of the extracts were very important in terms of any positive results.
32032761	7	42	theme	fish	1136:1139	arg1	bacteria					1152:1159	three fish pathogenic bacteria	1130:1159	three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae)	1130:1224	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	7	42	theme	fish	1136:1139	arg1	harveyi					1169:1175	Vibrio harveyi	1162:1175	Vibrio harveyi	1162:1175	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	7	42	theme	fish	1136:1139	arg1	anguillarum					1185:1195	Vibrio anguillarum	1178:1195	Vibrio anguillarum	1178:1195	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	7	42	theme	fish	1136:1139	arg1	damselae					1216:1223	Photobacterium damselae	1201:1223	Photobacterium damselae	1201:1223	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	9	43	theme	chemical	1581:1588	arg1	compounds					1590:1598	chemical compounds	1581:1598	chemical compounds with farmed fish	1581:1615	This work demonstrates interesting in vitro effects of carob leaf extracts and suggests it could be used as an alternative to chemical compounds with farmed fish.
32032761	3	44	theme	Aqueous	341:347	arg1	extracts					363:370	Aqueous and ethanolic extracts	341:370	Aqueous and ethanolic extracts obtained from carob	341:390	Aqueous and ethanolic extracts obtained from carob leaves were characterized in terms of biochemical composition, antiradical and cytotoxic effects and immunostimulant and antibacterial activities.
32032761	3	45	theme	composition	442:452	arg1	terms					421:425	terms	421:425	terms of biochemical composition, antiradical and cytotoxic effects and immunostimulant and antibacterial activities	421:536	Aqueous and ethanolic extracts obtained from carob leaves were characterized in terms of biochemical composition, antiradical and cytotoxic effects and immunostimulant and antibacterial activities.
32032761	5	46	theme	kidney	788:793	arg1	leucocytes					795:804	head kidney leucocytes	783:804	gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content)	749:886	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	0	47	from	study	12:16	arg1	seabream					90:97	gilthead seabream	81:97	gilthead seabream	81:97	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	2	48	theme	renewable	266:274	arg1	Carob					192:196	Carob	192:196	Carob leaves	192:203	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	2	48	theme	renewable	266:274	arg1	source					289:294	a renewable and abundant source	264:294	a renewable and abundant source of bioactive compounds for fish aquaculture	264:338	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	7	49	theme	extracts	1260:1267	arg1	activity					1234:1241	notable activity	1226:1241	notable activity of the different extracts	1226:1267	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	0	50	from	seabream	90:97	arg1	aurata					107:112	Sparus aurata L.	100:115	Sparus aurata L.	100:115	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	0	50	from	seabream	90:97	arg1	study					12:16	An in vitro study	0:16	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.)	0:116	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	8	51	theme	same	1425:1428	arg1	range					1430:1434	the same range	1421:1434	the same range of concentrations	1421:1452	A similar effect was demonstrated against V. haryeri when ethanolic extracts were used in the same range of concentrations.
32032761	3	52	theme	cytotoxic	471:479	arg1	effects					481:487	antiradical and cytotoxic effects	455:487	antiradical and cytotoxic effects	455:487	Aqueous and ethanolic extracts obtained from carob leaves were characterized in terms of biochemical composition, antiradical and cytotoxic effects and immunostimulant and antibacterial activities.
32032761	4	53	theme	phenolics	591:599	arg1	levels					575:580	higher levels	568:580	higher levels of total phenolics, flavonoids and condensed tannins	568:633	The ethanolic extract showed higher levels of total phenolics, flavonoids and condensed tannins and higher antioxidant activity than the aqueous extract.
32032761	4	53	theme	phenolics	591:599	arg1	activity					658:665	higher antioxidant activity	639:665	higher antioxidant activity	639:665	The ethanolic extract showed higher levels of total phenolics, flavonoids and condensed tannins and higher antioxidant activity than the aqueous extract.
32032761	3	54	theme	antiradical	455:465	arg1	effects					481:487	antiradical and cytotoxic effects	455:487	antiradical and cytotoxic effects	455:487	Aqueous and ethanolic extracts obtained from carob leaves were characterized in terms of biochemical composition, antiradical and cytotoxic effects and immunostimulant and antibacterial activities.
32032761	9	55	with	compounds	1590:1598	arg1	fish					1612:1615	farmed fish	1605:1615	farmed fish	1605:1615	This work demonstrates interesting in vitro effects of carob leaf extracts and suggests it could be used as an alternative to chemical compounds with farmed fish.
32032761	2	56	theme	tree	237:240	arg1	Carob					192:196	Carob	192:196	Carob leaves	192:203	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	2	56	theme	tree	237:240	arg1	tree					237:240	the carob tree	227:240	the carob tree	227:240	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	2	56	theme	tree	237:240	arg1	residues					215:222	the main residues	206:222	the main residues of the carob tree	206:240	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	4	57	theme	higher	568:573	arg1	levels					575:580	higher levels	568:580	higher levels of total phenolics, flavonoids and condensed tannins	568:633	The ethanolic extract showed higher levels of total phenolics, flavonoids and condensed tannins and higher antioxidant activity than the aqueous extract.
32032761	2	58	theme	abundant	280:287	arg1	Carob					192:196	Carob	192:196	Carob leaves	192:203	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	2	58	theme	abundant	280:287	arg1	source					289:294	a renewable and abundant source	264:294	a renewable and abundant source of bioactive compounds for fish aquaculture	264:338	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	0	59	theme	effect	25:30	arg1	aurata					107:112	Sparus aurata L.	100:115	Sparus aurata L.	100:115	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	0	59	theme	effect	25:30	arg1	study					12:16	An in vitro study	0:16	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.)	0:116	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	7	60	theme	Photobacterium	1201:1214	arg1	bacteria					1152:1159	three fish pathogenic bacteria	1130:1159	three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae)	1130:1224	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	7	60	theme	Photobacterium	1201:1214	arg1	damselae					1216:1223	Photobacterium damselae	1201:1223	Photobacterium damselae	1201:1223	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	5	61	theme	peroxidase	868:877	arg1	content					879:885	peroxidase content	868:885	peroxidase content	868:885	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	4	62	theme	antioxidant	646:656	arg1	activity					658:665	higher antioxidant activity	639:665	higher antioxidant activity	639:665	The ethanolic extract showed higher levels of total phenolics, flavonoids and condensed tannins and higher antioxidant activity than the aqueous extract.
32032761	0	63	theme	gilthead	81:88	arg1	seabream					90:97	gilthead seabream	81:97	gilthead seabream	81:97	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	3	64	theme	activities	527:536	arg1	terms					421:425	terms	421:425	terms of biochemical composition, antiradical and cytotoxic effects and immunostimulant and antibacterial activities	421:536	Aqueous and ethanolic extracts obtained from carob leaves were characterized in terms of biochemical composition, antiradical and cytotoxic effects and immunostimulant and antibacterial activities.
32032761	5	65	theme	phagocytosis	818:829	arg1	activities					853:862	viability, phagocytosis and respiratory burst activities	807:862	viability, phagocytosis and respiratory burst activities	807:862	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	4	66	theme	flavonoids	602:611	arg1	levels					575:580	higher levels	568:580	higher levels of total phenolics, flavonoids and condensed tannins	568:633	The ethanolic extract showed higher levels of total phenolics, flavonoids and condensed tannins and higher antioxidant activity than the aqueous extract.
32032761	4	66	theme	flavonoids	602:611	arg1	activity					658:665	higher antioxidant activity	639:665	higher antioxidant activity	639:665	The ethanolic extract showed higher levels of total phenolics, flavonoids and condensed tannins and higher antioxidant activity than the aqueous extract.
32032761	5	67	theme	significant	696:706	arg1	effects					724:730	No significant immunostimulant effects	693:730	No significant immunostimulant effects	693:730	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	5	68	theme	respiratory	835:845	arg1	burst					847:851	respiratory burst	835:851	respiratory burst	835:851	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	5	69	dep	seabream	758:765	arg1	leucocytes					795:804	head kidney leucocytes	783:804	gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content)	749:886	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	4	70	theme	condensed	617:625	arg1	tannins					627:633	condensed tannins	617:633	condensed tannins	617:633	The ethanolic extract showed higher levels of total phenolics, flavonoids and condensed tannins and higher antioxidant activity than the aqueous extract.
32032761	9	71	theme	in	1490:1491	arg1	effects					1499:1505	interesting in vitro effects	1478:1505	interesting in vitro effects of carob leaf extracts	1478:1528	This work demonstrates interesting in vitro effects of carob leaf extracts and suggests it could be used as an alternative to chemical compounds with farmed fish.
32032761	10	72	theme	results	1708:1714	arg1	terms					1686:1690	terms	1686:1690	terms of any positive results	1686:1714	The concentration and nature of the extracts were very important in terms of any positive results.
32032761	5	73	theme	different	919:927	arg1	extracts					929:936	different extracts	919:936	different extracts	919:936	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	5	74	theme	gilthead	749:756	arg1	seabream					758:765	gilthead seabream	749:765	gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content)	749:886	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	5	74	theme	gilthead	749:756	arg1	aurata					775:780	Sparus aurata	768:780	Sparus aurata	768:780	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	9	75	theme	carob	1510:1514	arg1	extracts					1521:1528	carob leaf extracts	1510:1528	carob leaf extracts	1510:1528	This work demonstrates interesting in vitro effects of carob leaf extracts and suggests it could be used as an alternative to chemical compounds with farmed fish.
32032761	6	76	contain	had	1040:1042	arg2	effect					1056:1061	a cytotoxic effect	1044:1061	a cytotoxic effect on PLHC-1 cells	1044:1077	Furthermore, the ethanolic extracts used at 0.5, 0.75 and 1 mg mL-1 and aqueous extracts at 1 g mL-1 had a cytotoxic effect on PLHC-1 cells.
32032761	6	76	contain	had	1040:1042	arg1	extracts					966:973	the ethanolic extracts	952:973	the ethanolic extracts used at 0.5, 0.75 and 1 mg mL-1	952:1005	Furthermore, the ethanolic extracts used at 0.5, 0.75 and 1 mg mL-1 and aqueous extracts at 1 g mL-1 had a cytotoxic effect on PLHC-1 cells.
32032761	6	76	contain	had	1040:1042	arg1	extracts					1019:1026	aqueous extracts	1011:1026	aqueous extracts at 1 g mL-1	1011:1038	Furthermore, the ethanolic extracts used at 0.5, 0.75 and 1 mg mL-1 and aqueous extracts at 1 g mL-1 had a cytotoxic effect on PLHC-1 cells.
32032761	5	77	located	observed	737:744	arg1	seabream					758:765	gilthead seabream	749:765	gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content)	749:886	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	5	77	located	observed	737:744	arg1	aurata					775:780	Sparus aurata	768:780	Sparus aurata	768:780	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	5	77	located	observed	737:744	arg2	effects					724:730	No significant immunostimulant effects	693:730	No significant immunostimulant effects	693:730	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	9	78	theme	extracts	1521:1528	arg1	effects					1499:1505	interesting in vitro effects	1478:1505	interesting in vitro effects of carob leaf extracts	1478:1528	This work demonstrates interesting in vitro effects of carob leaf extracts and suggests it could be used as an alternative to chemical compounds with farmed fish.
32032761	7	79	dep	bacteria	1152:1159	arg1	bacteria					1152:1159	three fish pathogenic bacteria	1130:1159	three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae)	1130:1224	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	7	79	dep	bacteria	1152:1159	arg1	harveyi					1169:1175	Vibrio harveyi	1162:1175	Vibrio harveyi	1162:1175	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	7	79	dep	bacteria	1152:1159	arg1	anguillarum					1185:1195	Vibrio anguillarum	1178:1195	Vibrio anguillarum	1178:1195	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	7	79	dep	bacteria	1152:1159	arg1	damselae					1216:1223	Photobacterium damselae	1201:1223	Photobacterium damselae	1201:1223	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	4	80	theme	aqueous	676:682	arg1	extract					684:690	the aqueous extract	672:690	the aqueous extract	672:690	The ethanolic extract showed higher levels of total phenolics, flavonoids and condensed tannins and higher antioxidant activity than the aqueous extract.
32032761	7	81	theme	Vibrio	1178:1183	arg1	bacteria					1152:1159	three fish pathogenic bacteria	1130:1159	three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae)	1130:1224	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	7	81	theme	Vibrio	1178:1183	arg1	anguillarum					1185:1195	Vibrio anguillarum	1178:1195	Vibrio anguillarum	1178:1195	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	0	82	theme	extracts	69:76	arg1	effect					25:30	the effect	21:30	the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream	21:97	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	8	83	used	used	1413:1416	arg2	extracts					1399:1406	ethanolic extracts	1389:1406	ethanolic extracts	1389:1406	A similar effect was demonstrated against V. haryeri when ethanolic extracts were used in the same range of concentrations.
32032761	0	84	theme	in	3:4	arg1	aurata					107:112	Sparus aurata L.	100:115	Sparus aurata L.	100:115	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	0	84	theme	in	3:4	arg1	study					12:16	An in vitro study	0:16	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.)	0:116	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	5	85	theme	viability	807:815	arg1	activities					853:862	viability, phagocytosis and respiratory burst activities	807:862	viability, phagocytosis and respiratory burst activities	807:862	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	4	86	theme	ethanolic	543:551	arg1	extract					553:559	The ethanolic extract	539:559	The ethanolic extract	539:559	The ethanolic extract showed higher levels of total phenolics, flavonoids and condensed tannins and higher antioxidant activity than the aqueous extract.
32032761	8	87	theme	V.	1373:1374	arg1	haryeri					1376:1382	V. haryeri	1373:1382	V. haryeri	1373:1382	A similar effect was demonstrated against V. haryeri when ethanolic extracts were used in the same range of concentrations.
32032761	2	88	theme	compounds	309:317	arg1	Carob					192:196	Carob	192:196	Carob leaves	192:203	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	2	88	theme	compounds	309:317	arg1	source					289:294	a renewable and abundant source	264:294	a renewable and abundant source of bioactive compounds for fish aquaculture	264:338	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	0	89	dep	activities	128:137	arg1	aurata					107:112	Sparus aurata L.	100:115	Sparus aurata L.	100:115	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	0	89	dep	activities	128:137	arg1	study					12:16	An in vitro study	0:16	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.)	0:116	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	5	90	theme	head	783:786	arg1	leucocytes					795:804	head kidney leucocytes	783:804	gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content)	749:886	No significant immunostimulant effects were observed on gilthead seabream (Sparus aurata) head kidney leucocytes (viability, phagocytosis and respiratory burst activities and peroxidase content) after incubation for 24 h with different extracts.
32032761	0	91	dep	aurata	107:112	arg1	L.					114:115	Sparus aurata L.	100:115	Sparus aurata L.	100:115	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	2	92	theme	bioactive	299:307	arg1	compounds					309:317	bioactive compounds	299:317	bioactive compounds	299:317	Carob leaves, the main residues of the carob tree, were investigated as a renewable and abundant source of bioactive compounds for fish aquaculture.
32032761	9	93	theme	farmed	1605:1610	arg1	fish					1612:1615	farmed fish	1605:1615	farmed fish	1605:1615	This work demonstrates interesting in vitro effects of carob leaf extracts and suggests it could be used as an alternative to chemical compounds with farmed fish.
32032761	7	94	theme	different	1250:1258	arg1	extracts					1260:1267	the different extracts	1246:1267	the different extracts	1246:1267	When the bactericidal activity was tested against three fish pathogenic bacteria (Vibrio harveyi, Vibrio anguillarum and Photobacterium damselae) notable activity of the different extracts was detected against P. damselae at all three concentrations.
32032761	4	95	theme	total	585:589	arg1	phenolics					591:599	total phenolics	585:599	total phenolics	585:599	The ethanolic extract showed higher levels of total phenolics, flavonoids and condensed tannins and higher antioxidant activity than the aqueous extract.
32032761	10	96	dep	concentration	1622:1634	arg1	The					1618:1620	The	1618:1620	The	1618:1620	The concentration and nature of the extracts were very important in terms of any positive results.
32032761	3	97	theme	biochemical	430:440	arg1	composition					442:452	biochemical composition	430:452	biochemical composition	430:452	Aqueous and ethanolic extracts obtained from carob leaves were characterized in terms of biochemical composition, antiradical and cytotoxic effects and immunostimulant and antibacterial activities.
32032761	1	98	theme	bactericidal	167:178	arg1	properties					180:189	Antioxidant, cytotoxic and bactericidal properties	140:189	Antioxidant, cytotoxic and bactericidal properties	140:189	Antioxidant, cytotoxic and bactericidal properties.
32032761	0	99	dep	in	3:4	arg1	vitro					6:10	vitro	6:10	vitro	6:10	An in vitro study of the effect of carob (Ceratonia siliqua L.) leaf extracts on gilthead seabream (Sparus aurata L.) leucocyte activities.
32032761	10	100	theme	positive	1699:1706	arg1	results					1708:1714	any positive results	1695:1714	any positive results	1695:1714	The concentration and nature of the extracts were very important in terms of any positive results.
32032761	3	101	theme	effects	481:487	arg1	terms					421:425	terms	421:425	terms of biochemical composition, antiradical and cytotoxic effects and immunostimulant and antibacterial activities	421:536	Aqueous and ethanolic extracts obtained from carob leaves were characterized in terms of biochemical composition, antiradical and cytotoxic effects and immunostimulant and antibacterial activities.
33154467	3	0	from	use	420:422	arg1	applications					435:446	broader applications	427:446	broader applications	427:446	Scaling the production capacity of W-CNCs isolation has led to their use in broader applications and captured the interest of researchers, industries and governments alike.
33154467	3	1	theme	researchers	477:487	arg1	interest					465:472	the interest	461:472	the interest of researchers, industries and governments alike	461:521	Scaling the production capacity of W-CNCs isolation has led to their use in broader applications and captured the interest of researchers, industries and governments alike.
33154467	9	2	theme	potential	1382:1390	arg1	solution					1392:1399	a potential solution	1380:1399	a potential solution to the numerous challenges which invasive tunicates pose to global aquaculture communities	1380:1490	Demonstrating a significant step towards commercial scale isolation of T-CNCs, and offering a potential solution to the numerous challenges which invasive tunicates pose to global aquaculture communities.
33154467	5	3	theme	available	731:739	arg1	W-CNCs					741:746	commercially available W-CNCs	718:746	commercially available W-CNCs	718:746	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	7	4	theme	pilot	1106:1110	arg1	scale					1112:1116	pilot scale	1106:1116	pilot scale	1106:1116	The reported procedure utilizes scalable CNC processing techniques and is based on our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation.
33154467	5	5	theme	derived	646:652	arg1	T-CNCs					660:665	T-CNCs	660:665	T-CNCs	660:665	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	5	5	theme	derived	646:652	arg1	CNCs					654:657	Tunicate derived CNCs	637:657	Tunicate derived CNCs (T-CNCs)	637:666	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	5	5	theme	derived	646:652	arg1	CNC					692:694	a high aspect ratio CNC	672:694	a high aspect ratio CNC	672:694	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	6	6	theme	aquaculture	940:950	arg1	communities					952:962	local aquaculture communities	934:962	local aquaculture communities	934:962	Herein we report the isolation and characterization of T-CNCs from the tunicate Styela clava, an invasive species currently causing significant harm to local aquaculture communities.
33154467	5	7	theme	ratio	686:690	arg1	CNCs					654:657	Tunicate derived CNCs	637:657	Tunicate derived CNCs (T-CNCs)	637:666	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	5	7	theme	ratio	686:690	arg1	CNC					692:694	a high aspect ratio CNC	672:694	a high aspect ratio CNC	672:694	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	6	8	theme	Styela	862:867	arg1	clava					869:873	the tunicate Styela clava	849:873	the tunicate Styela clava	849:873	Herein we report the isolation and characterization of T-CNCs from the tunicate Styela clava, an invasive species currently causing significant harm to local aquaculture communities.
33154467	5	9	theme	Tunicate	637:644	arg1	T-CNCs					660:665	T-CNCs	660:665	T-CNCs	660:665	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	5	9	theme	Tunicate	637:644	arg1	CNCs					654:657	Tunicate derived CNCs	637:657	Tunicate derived CNCs (T-CNCs)	637:666	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	5	9	theme	Tunicate	637:644	arg1	CNC					692:694	a high aspect ratio CNC	672:694	a high aspect ratio CNC	672:694	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	2	10	from	scale	307:311	arg1	available					272:280	available	272:280	available	272:280	Currently the only CNCs available commercially in kilogram scale are obtained from wood pulp (W-CNCs).
33154467	4	11	theme	scale	577:581	arg1	production					583:592	commercial scale production	566:592	commercial scale production	566:592	Another source of CNCs with potential for commercial scale production are tunicates, a species of marine animal.
33154467	6	12	theme	tunicate	853:860	arg1	clava					869:873	the tunicate Styela clava	849:873	the tunicate Styela clava	849:873	Herein we report the isolation and characterization of T-CNCs from the tunicate Styela clava, an invasive species currently causing significant harm to local aquaculture communities.
33154467	4	13	with	CNCs	542:545	arg1	potential					552:560	potential	552:560	potential for commercial scale production	552:592	Another source of CNCs with potential for commercial scale production are tunicates, a species of marine animal.
33154467	2	14	theme	available	272:280	arg1	CNCs					267:270	Currently the only CNCs	248:270	Currently the only CNCs available commercially in kilogram scale	248:311	Currently the only CNCs available commercially in kilogram scale are obtained from wood pulp (W-CNCs).
33154467	4	15	theme	commercial	566:575	arg1	production					583:592	commercial scale production	566:592	commercial scale production	566:592	Another source of CNCs with potential for commercial scale production are tunicates, a species of marine animal.
33154467	7	16	theme	laboratory	1069:1078	arg1	scale					1080:1084	laboratory scale T-CNC isolation and pilot scale W-CNC isolation	1069:1132	scale	1080:1084	The reported procedure utilizes scalable CNC processing techniques and is based on our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation.
33154467	9	17	theme	commercial	1329:1338	arg1	isolation					1346:1354	commercial scale isolation	1329:1354	commercial scale isolation of T-CNCs	1329:1364	Demonstrating a significant step towards commercial scale isolation of T-CNCs, and offering a potential solution to the numerous challenges which invasive tunicates pose to global aquaculture communities.
33154467	3	18	theme	governments	505:515	arg1	alike					517:521	governments alike	505:521	governments alike	505:521	Scaling the production capacity of W-CNCs isolation has led to their use in broader applications and captured the interest of researchers, industries and governments alike.
33154467	9	19	theme	numerous	1408:1415	arg1	challenges					1417:1426	the numerous challenges	1404:1426	the numerous challenges which invasive tunicates pose to global aquaculture communities	1404:1490	Demonstrating a significant step towards commercial scale isolation of T-CNCs, and offering a potential solution to the numerous challenges which invasive tunicates pose to global aquaculture communities.
33154467	0	20	theme	nanocrystals	44:55	arg1	isolation					21:29	the scalable isolation	8:29	the scalable isolation of cellulose nanocrystals from tunicates	8:70	Towards the scalable isolation of cellulose nanocrystals from tunicates.
33154467	3	21	theme	isolation	393:401	arg1	capacity					374:381	the production capacity	359:381	Scaling the production capacity of W-CNCs isolation	351:401	Scaling the production capacity of W-CNCs isolation has led to their use in broader applications and captured the interest of researchers, industries and governments alike.
33154467	3	22	theme	alike	517:521	arg1	interest					465:472	the interest	461:472	the interest of researchers, industries and governments alike	461:521	Scaling the production capacity of W-CNCs isolation has led to their use in broader applications and captured the interest of researchers, industries and governments alike.
33154467	4	23	theme	animal	629:634	arg1	tunicates					598:606	tunicates	598:606	tunicates	598:606	Another source of CNCs with potential for commercial scale production are tunicates, a species of marine animal.
33154467	4	23	theme	animal	629:634	arg1	species					611:617	a species	609:617	a species of marine animal	609:634	Another source of CNCs with potential for commercial scale production are tunicates, a species of marine animal.
33154467	3	24	theme	production	363:372	arg1	capacity					374:381	the production capacity	359:381	Scaling the production capacity of W-CNCs isolation	351:401	Scaling the production capacity of W-CNCs isolation has led to their use in broader applications and captured the interest of researchers, industries and governments alike.
33154467	4	25	theme	CNCs	542:545	arg1	tunicates					598:606	tunicates	598:606	tunicates	598:606	Another source of CNCs with potential for commercial scale production are tunicates, a species of marine animal.
33154467	4	25	theme	CNCs	542:545	arg1	source					532:537	Another source	524:537	Another source of CNCs with potential for commercial scale production	524:592	Another source of CNCs with potential for commercial scale production are tunicates, a species of marine animal.
33154467	9	26	theme	significant	1304:1314	arg1	step					1316:1319	a significant step	1302:1319	a significant step towards commercial scale isolation of T-CNCs	1302:1364	Demonstrating a significant step towards commercial scale isolation of T-CNCs, and offering a potential solution to the numerous challenges which invasive tunicates pose to global aquaculture communities.
33154467	1	27	theme	industrial	168:177	arg1	applications					179:190	industrial applications	168:190	industrial applications	168:190	In order for sustainable nanomaterials such as cellulose nanocrystals (CNCs) to be utilized in industrial applications, a large-scale production capacity for CNCs must exist.
33154467	5	28	theme	CNC	770:772	arg1	market					774:779	the growing global CNC market	751:779	the growing global CNC market	751:779	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	6	29	theme	local	934:938	arg1	communities					952:962	local aquaculture communities	934:962	local aquaculture communities	934:962	Herein we report the isolation and characterization of T-CNCs from the tunicate Styela clava, an invasive species currently causing significant harm to local aquaculture communities.
33154467	8	30	theme	largest	1184:1190	arg1	scale					1192:1196	the largest scale	1180:1196	the largest scale where T-CNCs have been isolated from any tunicate species, under any reaction conditions	1180:1285	To our best knowledge, this study represents the largest scale where T-CNCs have been isolated from any tunicate species, under any reaction conditions.
33154467	1	31	theme	sustainable	86:96	arg1	nanocrystals					130:141	cellulose nanocrystals	120:141	cellulose nanocrystals (CNCs)	120:148	In order for sustainable nanomaterials such as cellulose nanocrystals (CNCs) to be utilized in industrial applications, a large-scale production capacity for CNCs must exist.
33154467	1	31	theme	sustainable	86:96	arg1	nanomaterials					98:110	sustainable nanomaterials	86:110	sustainable nanomaterials such as cellulose nanocrystals (CNCs)	86:148	In order for sustainable nanomaterials such as cellulose nanocrystals (CNCs) to be utilized in industrial applications, a large-scale production capacity for CNCs must exist.
33154467	9	32	theme	invasive	1434:1441	arg1	tunicates					1443:1451	invasive tunicates	1434:1451	invasive tunicates	1434:1451	Demonstrating a significant step towards commercial scale isolation of T-CNCs, and offering a potential solution to the numerous challenges which invasive tunicates pose to global aquaculture communities.
33154467	3	33	theme	Scaling	351:357	arg1	capacity					374:381	the production capacity	359:381	Scaling the production capacity of W-CNCs isolation	351:401	Scaling the production capacity of W-CNCs isolation has led to their use in broader applications and captured the interest of researchers, industries and governments alike.
33154467	8	34	theme	best	1142:1145	arg1	knowledge					1147:1155	best knowledge	1142:1155	our best knowledge	1138:1155	To our best knowledge, this study represents the largest scale where T-CNCs have been isolated from any tunicate species, under any reaction conditions.
33154467	2	35	theme	kilogram	298:305	arg1	scale					307:311	kilogram scale	298:311	kilogram scale	298:311	Currently the only CNCs available commercially in kilogram scale are obtained from wood pulp (W-CNCs).
33154467	9	36	theme	T-CNCs	1359:1364	arg1	isolation					1346:1354	commercial scale isolation	1329:1354	commercial scale isolation of T-CNCs	1329:1364	Demonstrating a significant step towards commercial scale isolation of T-CNCs, and offering a potential solution to the numerous challenges which invasive tunicates pose to global aquaculture communities.
33154467	0	37	theme	scalable	12:19	arg1	isolation					21:29	the scalable isolation	8:29	the scalable isolation of cellulose nanocrystals from tunicates	8:70	Towards the scalable isolation of cellulose nanocrystals from tunicates.
33154467	7	38	dep	scale	1080:1084	arg1	isolation					1124:1132	W-CNC isolation	1118:1132	W-CNC isolation	1118:1132	The reported procedure utilizes scalable CNC processing techniques and is based on our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation.
33154467	7	38	dep	scale	1080:1084	arg1	isolation					1092:1100	T-CNC isolation	1086:1100	T-CNC isolation	1086:1100	The reported procedure utilizes scalable CNC processing techniques and is based on our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation.
33154467	7	39	theme	processing	1010:1019	arg1	techniques					1021:1030	scalable CNC processing techniques	997:1030	scalable CNC processing techniques	997:1030	The reported procedure utilizes scalable CNC processing techniques and is based on our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation.
33154467	5	40	link	derived	646:652	arg1	T-CNCs					660:665	T-CNCs	660:665	T-CNCs	660:665	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	5	40	link	derived	646:652	arg1	CNCs					654:657	Tunicate derived CNCs	637:657	Tunicate derived CNCs (T-CNCs)	637:666	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	5	40	link	derived	646:652	arg1	CNC					692:694	a high aspect ratio CNC	672:694	a high aspect ratio CNC	672:694	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	0	41	theme	cellulose	34:42	arg1	nanocrystals					44:55	cellulose nanocrystals	34:55	cellulose nanocrystals from tunicates	34:70	Towards the scalable isolation of cellulose nanocrystals from tunicates.
33154467	2	42	theme	wood	331:334	arg1	W-CNCs					342:347	W-CNCs	342:347	W-CNCs	342:347	Currently the only CNCs available commercially in kilogram scale are obtained from wood pulp (W-CNCs).
33154467	2	42	theme	wood	331:334	arg1	pulp					336:339	wood pulp	331:339	wood pulp (W-CNCs)	331:348	Currently the only CNCs available commercially in kilogram scale are obtained from wood pulp (W-CNCs).
33154467	5	43	theme	high	674:677	arg1	CNCs					654:657	Tunicate derived CNCs	637:657	Tunicate derived CNCs (T-CNCs)	637:666	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	5	43	theme	high	674:677	arg1	CNC					692:694	a high aspect ratio CNC	672:694	a high aspect ratio CNC	672:694	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	4	44	theme	marine	622:627	arg1	animal					629:634	marine animal	622:634	marine animal	622:634	Another source of CNCs with potential for commercial scale production are tunicates, a species of marine animal.
33154467	6	45	theme	significant	914:924	arg1	harm					926:929	significant harm	914:929	significant harm	914:929	Herein we report the isolation and characterization of T-CNCs from the tunicate Styela clava, an invasive species currently causing significant harm to local aquaculture communities.
33154467	1	46	theme	large-scale	195:205	arg1	capacity					218:225	a large-scale production capacity	193:225	a large-scale production capacity for CNCs	193:234	In order for sustainable nanomaterials such as cellulose nanocrystals (CNCs) to be utilized in industrial applications, a large-scale production capacity for CNCs must exist.
33154467	9	47	theme	scale	1340:1344	arg1	isolation					1346:1354	commercial scale isolation	1329:1354	commercial scale isolation of T-CNCs	1329:1364	Demonstrating a significant step towards commercial scale isolation of T-CNCs, and offering a potential solution to the numerous challenges which invasive tunicates pose to global aquaculture communities.
33154467	5	48	theme	aspect	679:684	arg1	CNCs					654:657	Tunicate derived CNCs	637:657	Tunicate derived CNCs (T-CNCs)	637:666	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	5	48	theme	aspect	679:684	arg1	CNC					692:694	a high aspect ratio CNC	672:694	a high aspect ratio CNC	672:694	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	9	49	theme	global	1461:1466	arg1	communities					1480:1490	global aquaculture communities	1461:1490	global aquaculture communities	1461:1490	Demonstrating a significant step towards commercial scale isolation of T-CNCs, and offering a potential solution to the numerous challenges which invasive tunicates pose to global aquaculture communities.
33154467	1	50	theme	production	207:216	arg1	capacity					218:225	a large-scale production capacity	193:225	a large-scale production capacity for CNCs	193:234	In order for sustainable nanomaterials such as cellulose nanocrystals (CNCs) to be utilized in industrial applications, a large-scale production capacity for CNCs must exist.
33154467	5	51	theme	growing	755:761	arg1	market					774:779	the growing global CNC market	751:779	the growing global CNC market	751:779	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
33154467	0	52	from	tunicates	62:70	arg1	isolation					21:29	the scalable isolation	8:29	the scalable isolation of cellulose nanocrystals from tunicates	8:70	Towards the scalable isolation of cellulose nanocrystals from tunicates.
33154467	0	52	from	tunicates	62:70	arg1	nanocrystals					44:55	cellulose nanocrystals	34:55	cellulose nanocrystals from tunicates	34:70	Towards the scalable isolation of cellulose nanocrystals from tunicates.
33154467	7	53	theme	scalable	997:1004	arg1	techniques					1021:1030	scalable CNC processing techniques	997:1030	scalable CNC processing techniques	997:1030	The reported procedure utilizes scalable CNC processing techniques and is based on our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation.
33154467	9	54	theme	aquaculture	1468:1478	arg1	communities					1480:1490	global aquaculture communities	1461:1490	global aquaculture communities	1461:1490	Demonstrating a significant step towards commercial scale isolation of T-CNCs, and offering a potential solution to the numerous challenges which invasive tunicates pose to global aquaculture communities.
33154467	3	55	theme	W-CNCs	386:391	arg1	isolation					393:401	W-CNCs isolation	386:401	W-CNCs isolation	386:401	Scaling the production capacity of W-CNCs isolation has led to their use in broader applications and captured the interest of researchers, industries and governments alike.
33154467	7	56	from	scale	1112:1116	arg1	experiences					1052:1062	our experiences	1048:1062	our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation	1048:1132	The reported procedure utilizes scalable CNC processing techniques and is based on our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation.
33154467	7	57	from	scale	1080:1084	arg1	experiences					1052:1062	our experiences	1048:1062	our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation	1048:1132	The reported procedure utilizes scalable CNC processing techniques and is based on our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation.
33154467	7	58	theme	reported	969:976	arg1	procedure					978:986	The reported procedure	965:986	The reported procedure	965:986	The reported procedure utilizes scalable CNC processing techniques and is based on our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation.
33154467	1	59	theme	cellulose	120:128	arg1	nanocrystals					130:141	cellulose nanocrystals	120:141	cellulose nanocrystals (CNCs)	120:148	In order for sustainable nanomaterials such as cellulose nanocrystals (CNCs) to be utilized in industrial applications, a large-scale production capacity for CNCs must exist.
33154467	1	59	theme	cellulose	120:128	arg1	CNCs					144:147	CNCs	144:147	CNCs	144:147	In order for sustainable nanomaterials such as cellulose nanocrystals (CNCs) to be utilized in industrial applications, a large-scale production capacity for CNCs must exist.
33154467	6	60	theme	invasive	879:886	arg1	species					888:894	an invasive species	876:894	an invasive species	876:894	Herein we report the isolation and characterization of T-CNCs from the tunicate Styela clava, an invasive species currently causing significant harm to local aquaculture communities.
33154467	7	61	theme	CNC	1006:1008	arg1	techniques					1021:1030	scalable CNC processing techniques	997:1030	scalable CNC processing techniques	997:1030	The reported procedure utilizes scalable CNC processing techniques and is based on our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation.
33154467	6	62	theme	T-CNCs	837:842	arg1	characterization					817:832	characterization	817:832	characterization	817:832	Herein we report the isolation and characterization of T-CNCs from the tunicate Styela clava, an invasive species currently causing significant harm to local aquaculture communities.
33154467	6	62	theme	T-CNCs	837:842	arg1	isolation					803:811	isolation	803:811	isolation	803:811	Herein we report the isolation and characterization of T-CNCs from the tunicate Styela clava, an invasive species currently causing significant harm to local aquaculture communities.
33154467	7	63	theme	W-CNC	1118:1122	arg1	isolation					1124:1132	W-CNC isolation	1118:1132	W-CNC isolation	1118:1132	The reported procedure utilizes scalable CNC processing techniques and is based on our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation.
33154467	8	64	attach	isolated	1221:1228	arg2	T-CNCs					1204:1209	T-CNCs	1204:1209	T-CNCs	1204:1209	To our best knowledge, this study represents the largest scale where T-CNCs have been isolated from any tunicate species, under any reaction conditions.
33154467	8	64	attach	isolated	1221:1228	arg1	species					1248:1254	any tunicate species	1235:1254	any tunicate species	1235:1254	To our best knowledge, this study represents the largest scale where T-CNCs have been isolated from any tunicate species, under any reaction conditions.
33154467	8	65	theme	tunicate	1239:1246	arg1	species					1248:1254	any tunicate species	1235:1254	any tunicate species	1235:1254	To our best knowledge, this study represents the largest scale where T-CNCs have been isolated from any tunicate species, under any reaction conditions.
33154467	2	66	theme	only	262:265	arg1	CNCs					267:270	Currently the only CNCs	248:270	Currently the only CNCs available commercially in kilogram scale	248:311	Currently the only CNCs available commercially in kilogram scale are obtained from wood pulp (W-CNCs).
33154467	7	67	theme	T-CNC	1086:1090	arg1	isolation					1092:1100	T-CNC isolation	1086:1100	T-CNC isolation	1086:1100	The reported procedure utilizes scalable CNC processing techniques and is based on our experiences from laboratory scale T-CNC isolation and pilot scale W-CNC isolation.
33154467	8	68	theme	reaction	1267:1274	arg1	conditions					1276:1285	any reaction conditions	1263:1285	any reaction conditions	1263:1285	To our best knowledge, this study represents the largest scale where T-CNCs have been isolated from any tunicate species, under any reaction conditions.
33154467	6	69	from	clava	869:873	arg1	characterization					817:832	characterization	817:832	characterization	817:832	Herein we report the isolation and characterization of T-CNCs from the tunicate Styela clava, an invasive species currently causing significant harm to local aquaculture communities.
33154467	6	69	from	clava	869:873	arg1	isolation					803:811	isolation	803:811	isolation	803:811	Herein we report the isolation and characterization of T-CNCs from the tunicate Styela clava, an invasive species currently causing significant harm to local aquaculture communities.
33154467	3	70	theme	broader	427:433	arg1	applications					435:446	broader applications	427:446	broader applications	427:446	Scaling the production capacity of W-CNCs isolation has led to their use in broader applications and captured the interest of researchers, industries and governments alike.
33154467	3	71	theme	industries	490:499	arg1	interest					465:472	the interest	461:472	the interest of researchers, industries and governments alike	461:521	Scaling the production capacity of W-CNCs isolation has led to their use in broader applications and captured the interest of researchers, industries and governments alike.
33154467	2	72	from	available	272:280	arg1	scale					307:311	kilogram scale	298:311	kilogram scale	298:311	Currently the only CNCs available commercially in kilogram scale are obtained from wood pulp (W-CNCs).
33154467	0	73	from	isolation	21:29	arg1	tunicates					62:70	tunicates	62:70	tunicates	62:70	Towards the scalable isolation of cellulose nanocrystals from tunicates.
33154467	5	74	theme	global	763:768	arg1	market					774:779	the growing global CNC market	751:779	the growing global CNC market	751:779	Tunicate derived CNCs (T-CNCs) are a high aspect ratio CNC, which can complement commercially available W-CNCs in the growing global CNC market.
34922964	8	0	theme	highest	1464:1470	arg1	level					1472:1476	the highest level	1460:1476	the highest level in 2 h	1460:1483	Further, the Pb2+ (10 mg/L) adsorption capacity of CMC-Fe3O4-RB reached the highest level in 2 h at the dosage of 0.01 g/L, and remained stable at 52.987 mg/g after five cycles of adsorption and desorption.
34922964	3	1	theme	bioactive	507:515	arg1	compounds					517:525	the bioactive compounds	503:525	the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS	503:591	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	4	2	theme	magnetic	847:854	arg1	Fe3O4					856:860	magnetic Fe3O4	847:860	magnetic Fe3O4	847:860	Fourier Transform Infrared and X-Ray Diffraction analysis showed that carboxymethyl cellulose (CMC) and magnetic Fe3O4 were successfully incorporated into raw biochar (RB) to form CMC-Fe3O4-RB nanomaterial.
34922964	3	3	theme	Vitamin	691:697	arg1	C					699:699	Vitamin C	691:699	Vitamin C used as an antioxidant in food additives	691:740	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	3	4	from	compounds	517:525	arg1	10 mg/mL					547:554	10 mg/mL	547:554	10 mg/mL	547:554	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	3	4	from	compounds	517:525	arg1	extract					538:544	acetone extract	530:544	acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS	530:591	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	4	5	theme	carboxymethyl	813:825	arg1	cellulose					827:835	carboxymethyl cellulose	813:835	carboxymethyl cellulose (CMC)	813:841	Fourier Transform Infrared and X-Ray Diffraction analysis showed that carboxymethyl cellulose (CMC) and magnetic Fe3O4 were successfully incorporated into raw biochar (RB) to form CMC-Fe3O4-RB nanomaterial.
34922964	4	5	theme	carboxymethyl	813:825	arg1	CMC					838:840	CMC	838:840	CMC	838:840	Fourier Transform Infrared and X-Ray Diffraction analysis showed that carboxymethyl cellulose (CMC) and magnetic Fe3O4 were successfully incorporated into raw biochar (RB) to form CMC-Fe3O4-RB nanomaterial.
34922964	6	6	theme	surface	1130:1136	arg1	area					1138:1141	a larger specific surface area	1112:1141	a larger specific surface area	1112:1141	Compared with RB, CMC-Fe3O4-RB had a larger specific surface area, pore volume and pore size.
34922964	6	7	theme	larger	1114:1119	arg1	area					1138:1141	a larger specific surface area	1112:1141	a larger specific surface area	1112:1141	Compared with RB, CMC-Fe3O4-RB had a larger specific surface area, pore volume and pore size.
34922964	9	8	theme	environment	1812:1822	arg1	fields					1784:1789	the fields	1780:1789	the fields of food industry and environment improvement	1780:1834	This research aided in the creation of a strategy for GBBs zero waste multistage usage and a circular economic model for GBBs industry development, which can be promoted and applied to the fields of food industry and environment improvement.
34922964	1	9	theme	bioactive	176:184	arg1	preparation					252:262	preparation	252:262	preparation	252:262	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	9	theme	bioactive	176:184	arg1	analysis					198:205	analysis	198:205	analysis of antioxidant and antibacterial activities	198:249	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	9	theme	bioactive	176:184	arg1	components					186:195	bioactive components	176:195	bioactive components	176:195	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	9	theme	bioactive	176:184	arg1	composition					268:278	composition	268:278	composition	268:278	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	4	10	theme	raw	898:900	arg1	RB					911:912	RB	911:912	RB	911:912	Fourier Transform Infrared and X-Ray Diffraction analysis showed that carboxymethyl cellulose (CMC) and magnetic Fe3O4 were successfully incorporated into raw biochar (RB) to form CMC-Fe3O4-RB nanomaterial.
34922964	4	10	theme	raw	898:900	arg1	biochar					902:908	raw biochar	898:908	raw biochar (RB)	898:913	Fourier Transform Infrared and X-Ray Diffraction analysis showed that carboxymethyl cellulose (CMC) and magnetic Fe3O4 were successfully incorporated into raw biochar (RB) to form CMC-Fe3O4-RB nanomaterial.
34922964	2	11	from	biomedicine	478:488	arg1	industry					433:440	the industry	429:440	the industry	429:440	The results showed that GBBs had abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine.
34922964	9	12	dep	food	1794:1797	arg1	industry					1799:1806	industry	1799:1806	industry	1799:1806	This research aided in the creation of a strategy for GBBs zero waste multistage usage and a circular economic model for GBBs industry development, which can be promoted and applied to the fields of food industry and environment improvement.
34922964	9	12	dep	food	1794:1797	arg1	improvement					1824:1834	improvement	1824:1834	improvement	1824:1834	This research aided in the creation of a strategy for GBBs zero waste multistage usage and a circular economic model for GBBs industry development, which can be promoted and applied to the fields of food industry and environment improvement.
34922964	8	13	theme	Pb2+	1401:1404	arg1	capacity					1427:1434	the Pb2+ (10 mg/L) adsorption capacity	1397:1434	the Pb2+ (10 mg/L) adsorption capacity of CMC-Fe3O4-RB	1397:1450	Further, the Pb2+ (10 mg/L) adsorption capacity of CMC-Fe3O4-RB reached the highest level in 2 h at the dosage of 0.01 g/L, and remained stable at 52.987 mg/g after five cycles of adsorption and desorption.
34922964	6	14	theme	pore	1160:1163	arg1	size					1165:1168	pore size	1160:1168	pore size	1160:1168	Compared with RB, CMC-Fe3O4-RB had a larger specific surface area, pore volume and pore size.
34922964	3	15	theme	scavenging	610:619	arg1	abilities					621:629	free radical scavenging abilities	597:629	free radical scavenging abilities of 92.28% and 98.18%, respectively	597:664	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	7	16	theme	adsorption	1307:1316	arg1	capacity					1318:1325	the adsorption capacity	1303:1325	the adsorption capacity of Pb2+, which was 29.90% higher than that of RB by ICP-OES	1303:1385	Meanwhile, nanomagnetic CMC-Fe3O4-RB solved the problem of agglomeration in traditional magnetized biochar production, and improved the adsorption capacity of Pb2+, which was 29.90% higher than that of RB by ICP-OES.
34922964	1	17	theme	biochar	328:334	arg1	reuse					310:314	reuse	310:314	reuse	310:314	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	17	theme	biochar	328:334	arg1	adsorption					295:304	adsorption	295:304	adsorption	295:304	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	17	theme	biochar	328:334	arg1	pyrolyzate					283:292	pyrolyzate	283:292	pyrolyzate	283:292	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	3	18	theme	free	597:600	arg1	scavenging					610:619	free radical scavenging	597:619	free radical scavenging abilities of 92.28% and 98.18%, respectively	597:664	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	9	19	theme	multistage	1665:1674	arg1	usage					1676:1680	GBBs zero waste multistage usage	1649:1680	GBBs zero waste multistage usage	1649:1680	This research aided in the creation of a strategy for GBBs zero waste multistage usage and a circular economic model for GBBs industry development, which can be promoted and applied to the fields of food industry and environment improvement.
34922964	8	20	theme	adsorption	1416:1425	arg1	capacity					1427:1434	the Pb2+ (10 mg/L) adsorption capacity	1397:1434	the Pb2+ (10 mg/L) adsorption capacity of CMC-Fe3O4-RB	1397:1450	Further, the Pb2+ (10 mg/L) adsorption capacity of CMC-Fe3O4-RB reached the highest level in 2 h at the dosage of 0.01 g/L, and remained stable at 52.987 mg/g after five cycles of adsorption and desorption.
34922964	9	21	theme	circular	1688:1695	arg1	model					1706:1710	a circular economic model	1686:1710	a circular economic model	1686:1710	This research aided in the creation of a strategy for GBBs zero waste multistage usage and a circular economic model for GBBs industry development, which can be promoted and applied to the fields of food industry and environment improvement.
34922964	1	22	dep	Ginkgo	111:116	arg1	branches					125:132	Ginkgo biloba branches	111:132	Ginkgo biloba branches (GBBs)	111:139	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	5	23	theme	CMC-Fe3O4-RB	1063:1074	arg1	surface					1052:1058	the surface	1048:1058	the surface of CMC-Fe3O4-RB	1048:1074	Scanning electron microscopy and X-Ray Diffraction spectroscopy displayed Fe, C, and O existed on the surface of CMC-Fe3O4-RB.
34922964	0	24	theme	Ginkgo	37:42	arg1	branches					51:58	Ginkgo biloba branches	37:58	Ginkgo biloba branches	37:58	Zero waste multistage utilization of Ginkgo biloba branches.
34922964	5	25	theme	Scanning	950:957	arg1	microscopy					968:977	Scanning electron microscopy	950:977	Scanning electron microscopy	950:977	Scanning electron microscopy and X-Ray Diffraction spectroscopy displayed Fe, C, and O existed on the surface of CMC-Fe3O4-RB.
34922964	2	26	from	materials	464:472	arg1	industry					433:440	the industry	429:440	the industry	429:440	The results showed that GBBs had abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine.
34922964	2	27	theme	bioactive	379:387	arg1	components					389:398	abundant bioactive components	370:398	abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine	370:488	The results showed that GBBs had abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine.
34922964	1	28	from	Ginkgo	111:116	arg1	utilization					83:93	Zero waste multistage utilization	61:93	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs)	61:139	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	9	29	theme	GBBs	1716:1719	arg1	development					1730:1740	GBBs industry development	1716:1740	GBBs industry development	1716:1740	This research aided in the creation of a strategy for GBBs zero waste multistage usage and a circular economic model for GBBs industry development, which can be promoted and applied to the fields of food industry and environment improvement.
34922964	0	30	theme	multistage	11:20	arg1	utilization					22:32	Zero waste multistage utilization	0:32	Zero waste multistage utilization of Ginkgo biloba branches.	0:59	Zero waste multistage utilization of Ginkgo biloba branches.
34922964	7	31	dep	Meanwhile	1171:1179	arg1	nanomagnetic					1182:1193	nanomagnetic	1182:1193	nanomagnetic	1182:1193	Meanwhile, nanomagnetic CMC-Fe3O4-RB solved the problem of agglomeration in traditional magnetized biochar production, and improved the adsorption capacity of Pb2+, which was 29.90% higher than that of RB by ICP-OES.
34922964	3	32	theme	%	639:639	arg1	abilities					621:629	free radical scavenging abilities	597:629	free radical scavenging abilities of 92.28% and 98.18%, respectively	597:664	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	4	33	theme	Diffraction	780:790	arg1	analysis					792:799	X-Ray Diffraction analysis	774:799	X-Ray Diffraction analysis	774:799	Fourier Transform Infrared and X-Ray Diffraction analysis showed that carboxymethyl cellulose (CMC) and magnetic Fe3O4 were successfully incorporated into raw biochar (RB) to form CMC-Fe3O4-RB nanomaterial.
34922964	7	34	theme	magnetized	1259:1268	arg1	production					1278:1287	traditional magnetized biochar production	1247:1287	traditional magnetized biochar production	1247:1287	Meanwhile, nanomagnetic CMC-Fe3O4-RB solved the problem of agglomeration in traditional magnetized biochar production, and improved the adsorption capacity of Pb2+, which was 29.90% higher than that of RB by ICP-OES.
34922964	2	35	theme	raw	460:462	arg1	materials					464:472	chemical raw materials	451:472	chemical raw materials	451:472	The results showed that GBBs had abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine.
34922964	9	36	theme	waste	1659:1663	arg1	usage					1676:1680	GBBs zero waste multistage usage	1649:1680	GBBs zero waste multistage usage	1649:1680	This research aided in the creation of a strategy for GBBs zero waste multistage usage and a circular economic model for GBBs industry development, which can be promoted and applied to the fields of food industry and environment improvement.
34922964	0	37	theme	biloba	44:49	arg1	branches					51:58	Ginkgo biloba branches	37:58	Ginkgo biloba branches	37:58	Zero waste multistage utilization of Ginkgo biloba branches.
34922964	8	38	theme	0.01 g/L	1502:1509	arg1	dosage					1492:1497	the dosage	1488:1497	the dosage of 0.01 g/L	1488:1509	Further, the Pb2+ (10 mg/L) adsorption capacity of CMC-Fe3O4-RB reached the highest level in 2 h at the dosage of 0.01 g/L, and remained stable at 52.987 mg/g after five cycles of adsorption and desorption.
34922964	1	39	theme	antioxidant	210:220	arg1	analysis					198:205	analysis	198:205	analysis of antioxidant and antibacterial activities	198:249	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	39	theme	antioxidant	210:220	arg1	components					186:195	bioactive components	176:195	bioactive components	176:195	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	5	40	theme	microscopy	968:977	arg1	spectroscopy					1001:1012	Scanning electron microscopy and X-Ray Diffraction spectroscopy	950:1012	Scanning electron microscopy and X-Ray Diffraction spectroscopy	950:1012	Scanning electron microscopy and X-Ray Diffraction spectroscopy displayed Fe, C, and O existed on the surface of CMC-Fe3O4-RB.
34922964	2	41	from	application	414:424	arg1	industry					433:440	the industry	429:440	the industry	429:440	The results showed that GBBs had abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine.
34922964	3	42	contain	had	593:595	arg2	abilities					621:629	free radical scavenging abilities	597:629	free radical scavenging abilities of 92.28% and 98.18%, respectively	597:664	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	3	42	contain	had	593:595	arg1	compounds					517:525	the bioactive compounds	503:525	the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS	503:591	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	1	43	theme	antibacterial	226:238	arg1	activities					240:249	antibacterial activities	226:249	antibacterial activities	226:249	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	5	44	theme	X-Ray	983:987	arg1	Diffraction					989:999	X-Ray Diffraction	983:999	X-Ray Diffraction	983:999	Scanning electron microscopy and X-Ray Diffraction spectroscopy displayed Fe, C, and O existed on the surface of CMC-Fe3O4-RB.
34922964	6	45	contain	had	1108:1110	arg1	CMC-Fe3O4-RB					1095:1106	CMC-Fe3O4-RB	1095:1106	CMC-Fe3O4-RB	1095:1106	Compared with RB, CMC-Fe3O4-RB had a larger specific surface area, pore volume and pore size.
34922964	6	45	contain	had	1108:1110	arg2	area					1138:1141	a larger specific surface area	1112:1141	a larger specific surface area	1112:1141	Compared with RB, CMC-Fe3O4-RB had a larger specific surface area, pore volume and pore size.
34922964	6	45	contain	had	1108:1110	arg2	size					1165:1168	pore size	1160:1168	pore size	1160:1168	Compared with RB, CMC-Fe3O4-RB had a larger specific surface area, pore volume and pore size.
34922964	6	45	contain	had	1108:1110	arg2	volume					1149:1154	pore volume	1144:1154	pore volume	1144:1154	Compared with RB, CMC-Fe3O4-RB had a larger specific surface area, pore volume and pore size.
34922964	9	46	theme	food	1794:1797	arg1	fields					1784:1789	the fields	1780:1789	the fields of food industry and environment improvement	1780:1834	This research aided in the creation of a strategy for GBBs zero waste multistage usage and a circular economic model for GBBs industry development, which can be promoted and applied to the fields of food industry and environment improvement.
34922964	3	47	theme	acetone	530:536	arg1	10 mg/mL					547:554	10 mg/mL	547:554	10 mg/mL	547:554	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	3	47	theme	acetone	530:536	arg1	extract					538:544	acetone extract	530:544	acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS	530:591	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	7	48	from	problem	1219:1225	arg1	production					1278:1287	traditional magnetized biochar production	1247:1287	traditional magnetized biochar production	1247:1287	Meanwhile, nanomagnetic CMC-Fe3O4-RB solved the problem of agglomeration in traditional magnetized biochar production, and improved the adsorption capacity of Pb2+, which was 29.90% higher than that of RB by ICP-OES.
34922964	6	49	theme	specific	1121:1128	arg1	area					1138:1141	a larger specific surface area	1112:1141	a larger specific surface area	1112:1141	Compared with RB, CMC-Fe3O4-RB had a larger specific surface area, pore volume and pore size.
34922964	3	50	theme	GBBs	560:563	arg1	10 mg/mL					547:554	10 mg/mL	547:554	10 mg/mL	547:554	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	3	50	theme	GBBs	560:563	arg1	extract					538:544	acetone extract	530:544	acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS	530:591	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	1	51	theme	components	186:195	arg1	extraction					162:171	extraction	162:171	extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar	162:334	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	9	52	theme	strategy	1636:1643	arg1	creation					1622:1629	the creation	1618:1629	the creation of a strategy for GBBs zero waste multistage usage and a circular economic model for GBBs industry development, which can be promoted and applied to the fields of food industry and environment improvement	1618:1834	This research aided in the creation of a strategy for GBBs zero waste multistage usage and a circular economic model for GBBs industry development, which can be promoted and applied to the fields of food industry and environment improvement.
34922964	3	53	theme	food	727:730	arg1	additives					732:740	food additives	727:740	food additives	727:740	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	3	54	theme	radical	602:608	arg1	scavenging					610:619	free radical scavenging	597:619	free radical scavenging abilities of 92.28% and 98.18%, respectively	597:664	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	9	55	theme	GBBs	1649:1652	arg1	usage					1676:1680	GBBs zero waste multistage usage	1649:1680	GBBs zero waste multistage usage	1649:1680	This research aided in the creation of a strategy for GBBs zero waste multistage usage and a circular economic model for GBBs industry development, which can be promoted and applied to the fields of food industry and environment improvement.
34922964	7	56	theme	Pb2+	1330:1333	arg1	capacity					1318:1325	the adsorption capacity	1303:1325	the adsorption capacity of Pb2+, which was 29.90% higher than that of RB by ICP-OES	1303:1385	Meanwhile, nanomagnetic CMC-Fe3O4-RB solved the problem of agglomeration in traditional magnetized biochar production, and improved the adsorption capacity of Pb2+, which was 29.90% higher than that of RB by ICP-OES.
34922964	7	57	theme	Meanwhile	1171:1179	arg1	CMC-Fe3O4-RB					1195:1206	Meanwhile, nanomagnetic CMC-Fe3O4-RB	1171:1206	Meanwhile, nanomagnetic CMC-Fe3O4-RB	1171:1206	Meanwhile, nanomagnetic CMC-Fe3O4-RB solved the problem of agglomeration in traditional magnetized biochar production, and improved the adsorption capacity of Pb2+, which was 29.90% higher than that of RB by ICP-OES.
34922964	3	58	dep	had	593:595	arg1	equivalent					677:686	equivalent	677:686	equivalent	677:686	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	4	59	theme	CMC-Fe3O4-RB	923:934	arg1	nanomaterial					936:947	CMC-Fe3O4-RB nanomaterial	923:947	CMC-Fe3O4-RB nanomaterial	923:947	Fourier Transform Infrared and X-Ray Diffraction analysis showed that carboxymethyl cellulose (CMC) and magnetic Fe3O4 were successfully incorporated into raw biochar (RB) to form CMC-Fe3O4-RB nanomaterial.
34922964	6	60	theme	pore	1144:1147	arg1	volume					1149:1154	pore volume	1144:1154	pore volume	1144:1154	Compared with RB, CMC-Fe3O4-RB had a larger specific surface area, pore volume and pore size.
34922964	8	61	theme	CMC-Fe3O4-RB	1439:1450	arg1	capacity					1427:1434	the Pb2+ (10 mg/L) adsorption capacity	1397:1434	the Pb2+ (10 mg/L) adsorption capacity of CMC-Fe3O4-RB	1397:1450	Further, the Pb2+ (10 mg/L) adsorption capacity of CMC-Fe3O4-RB reached the highest level in 2 h at the dosage of 0.01 g/L, and remained stable at 52.987 mg/g after five cycles of adsorption and desorption.
34922964	1	62	theme	waste	66:70	arg1	utilization					83:93	Zero waste multistage utilization	61:93	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs)	61:139	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	9	63	theme	economic	1697:1704	arg1	model					1706:1710	a circular economic model	1686:1710	a circular economic model	1686:1710	This research aided in the creation of a strategy for GBBs zero waste multistage usage and a circular economic model for GBBs industry development, which can be promoted and applied to the fields of food industry and environment improvement.
34922964	0	64	theme	waste	5:9	arg1	utilization					22:32	Zero waste multistage utilization	0:32	Zero waste multistage utilization of Ginkgo biloba branches.	0:59	Zero waste multistage utilization of Ginkgo biloba branches.
34922964	2	65	contain	had	366:368	arg1	GBBs					361:364	GBBs	361:364	GBBs	361:364	The results showed that GBBs had abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine.
34922964	2	65	contain	had	366:368	arg2	components					389:398	abundant bioactive components	370:398	abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine	370:488	The results showed that GBBs had abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine.
34922964	2	66	theme	food	445:448	arg1	application					414:424	potential application	404:424	potential application in the industry of food	404:448	The results showed that GBBs had abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine.
34922964	2	66	theme	food	445:448	arg1	biomedicine					478:488	biomedicine	478:488	biomedicine	478:488	The results showed that GBBs had abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine.
34922964	2	66	theme	food	445:448	arg1	materials					464:472	chemical raw materials	451:472	chemical raw materials	451:472	The results showed that GBBs had abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine.
34922964	3	67	from	antioxidant	712:722	arg1	additives					732:740	food additives	727:740	food additives	727:740	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	2	68	theme	abundant	370:377	arg1	components					389:398	abundant bioactive components	370:398	abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine	370:488	The results showed that GBBs had abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine.
34922964	1	69	theme	pyrolyzate	283:292	arg1	preparation					252:262	preparation	252:262	preparation	252:262	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	69	theme	pyrolyzate	283:292	arg1	components					186:195	bioactive components	176:195	bioactive components	176:195	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	69	theme	pyrolyzate	283:292	arg1	composition					268:278	composition	268:278	composition	268:278	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	70	theme	biomass	98:104	arg1	utilization					83:93	Zero waste multistage utilization	61:93	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs)	61:139	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	7	71	theme	biochar	1270:1276	arg1	production					1278:1287	traditional magnetized biochar production	1247:1287	traditional magnetized biochar production	1247:1287	Meanwhile, nanomagnetic CMC-Fe3O4-RB solved the problem of agglomeration in traditional magnetized biochar production, and improved the adsorption capacity of Pb2+, which was 29.90% higher than that of RB by ICP-OES.
34922964	9	72	theme	industry	1721:1728	arg1	development					1730:1740	GBBs industry development	1716:1740	GBBs industry development	1716:1740	This research aided in the creation of a strategy for GBBs zero waste multistage usage and a circular economic model for GBBs industry development, which can be promoted and applied to the fields of food industry and environment improvement.
34922964	8	73	from	level	1472:1476	arg1	2 h					1481:1483	2 h	1481:1483	2 h	1481:1483	Further, the Pb2+ (10 mg/L) adsorption capacity of CMC-Fe3O4-RB reached the highest level in 2 h at the dosage of 0.01 g/L, and remained stable at 52.987 mg/g after five cycles of adsorption and desorption.
34922964	1	74	theme	adsorption	295:304	arg1	preparation					252:262	preparation	252:262	preparation	252:262	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	74	theme	adsorption	295:304	arg1	components					186:195	bioactive components	176:195	bioactive components	176:195	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	74	theme	adsorption	295:304	arg1	composition					268:278	composition	268:278	composition	268:278	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	5	75	theme	Diffraction	989:999	arg1	spectroscopy					1001:1012	Scanning electron microscopy and X-Ray Diffraction spectroscopy	950:1012	Scanning electron microscopy and X-Ray Diffraction spectroscopy	950:1012	Scanning electron microscopy and X-Ray Diffraction spectroscopy displayed Fe, C, and O existed on the surface of CMC-Fe3O4-RB.
34922964	7	76	theme	traditional	1247:1257	arg1	production					1278:1287	traditional magnetized biochar production	1247:1287	traditional magnetized biochar production	1247:1287	Meanwhile, nanomagnetic CMC-Fe3O4-RB solved the problem of agglomeration in traditional magnetized biochar production, and improved the adsorption capacity of Pb2+, which was 29.90% higher than that of RB by ICP-OES.
34922964	4	77	theme	X-Ray	774:778	arg1	analysis					792:799	X-Ray Diffraction analysis	774:799	X-Ray Diffraction analysis	774:799	Fourier Transform Infrared and X-Ray Diffraction analysis showed that carboxymethyl cellulose (CMC) and magnetic Fe3O4 were successfully incorporated into raw biochar (RB) to form CMC-Fe3O4-RB nanomaterial.
34922964	2	78	theme	potential	404:412	arg1	application					414:424	potential application	404:424	potential application in the industry of food	404:448	The results showed that GBBs had abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine.
34922964	0	79	theme	branches	51:58	arg1	utilization					22:32	Zero waste multistage utilization	0:32	Zero waste multistage utilization of Ginkgo biloba branches.	0:59	Zero waste multistage utilization of Ginkgo biloba branches.
34922964	1	80	theme	reuse	310:314	arg1	preparation					252:262	preparation	252:262	preparation	252:262	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	80	theme	reuse	310:314	arg1	components					186:195	bioactive components	176:195	bioactive components	176:195	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	80	theme	reuse	310:314	arg1	composition					268:278	composition	268:278	composition	268:278	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	7	81	theme	agglomeration	1230:1242	arg1	problem					1219:1225	the problem	1215:1225	the problem of agglomeration in traditional magnetized biochar production	1215:1287	Meanwhile, nanomagnetic CMC-Fe3O4-RB solved the problem of agglomeration in traditional magnetized biochar production, and improved the adsorption capacity of Pb2+, which was 29.90% higher than that of RB by ICP-OES.
34922964	2	82	theme	chemical	451:458	arg1	materials					464:472	chemical raw materials	451:472	chemical raw materials	451:472	The results showed that GBBs had abundant bioactive components for potential application in the industry of food, chemical raw materials and biomedicine.
34922964	3	83	theme	%	650:650	arg1	abilities					621:629	free radical scavenging abilities	597:629	free radical scavenging abilities of 92.28% and 98.18%, respectively	597:664	Especially, the bioactive compounds in acetone extract (10 mg/mL) of GBBs identified by DPPH and ABTS had free radical scavenging abilities of 92.28% and 98.18%, respectively, which are equivalent to Vitamin C used as an antioxidant in food additives.
34922964	8	84	theme	adsorption	1568:1577	arg1	cycles					1558:1563	five cycles	1553:1563	five cycles of adsorption and desorption	1553:1592	Further, the Pb2+ (10 mg/L) adsorption capacity of CMC-Fe3O4-RB reached the highest level in 2 h at the dosage of 0.01 g/L, and remained stable at 52.987 mg/g after five cycles of adsorption and desorption.
34922964	1	85	theme	modified	319:326	arg1	biochar					328:334	modified biochar	319:334	modified biochar	319:334	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	5	86	theme	electron	959:966	arg1	microscopy					968:977	Scanning electron microscopy	950:977	Scanning electron microscopy	950:977	Scanning electron microscopy and X-Ray Diffraction spectroscopy displayed Fe, C, and O existed on the surface of CMC-Fe3O4-RB.
34922964	1	87	theme	multistage	72:81	arg1	utilization					83:93	Zero waste multistage utilization	61:93	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs)	61:139	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	8	88	theme	desorption	1583:1592	arg1	cycles					1558:1563	five cycles	1553:1563	five cycles of adsorption and desorption	1553:1592	Further, the Pb2+ (10 mg/L) adsorption capacity of CMC-Fe3O4-RB reached the highest level in 2 h at the dosage of 0.01 g/L, and remained stable at 52.987 mg/g after five cycles of adsorption and desorption.
34922964	1	89	theme	activities	240:249	arg1	analysis					198:205	analysis	198:205	analysis of antioxidant and antibacterial activities	198:249	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
34922964	1	89	theme	activities	240:249	arg1	components					186:195	bioactive components	176:195	bioactive components	176:195	Zero waste multistage utilization of biomass from Ginkgo biloba branches (GBBs) was achieved through extraction of bioactive components, analysis of antioxidant and antibacterial activities, preparation and composition of pyrolyzate, adsorption and reuse of modified biochar.
33321615	7	0	theme	increased	1108:1116	arg1	activities					1148:1157	increased antioxidant and antimicrobial activities	1108:1157	increased antioxidant and antimicrobial activities	1108:1157	Both formulations improved the bioaccessibility of different phenolics following in vitro GI digestion, leading to increased antioxidant and antimicrobial activities.
33321615	9	1	theme	Caco-2	1400:1405	arg1	cells					1420:1424	Caco-2 and HT29-MTX cells	1400:1424	Caco-2 and HT29-MTX cells	1400:1424	Cy5.5 was used for tracking the CS NPs, which did not affect the metabolic activity of Caco-2 and HT29-MTX cells.
33321615	7	2	theme	antioxidant	1118:1128	arg1	activities					1148:1157	increased antioxidant and antimicrobial activities	1108:1157	increased antioxidant and antimicrobial activities	1108:1157	Both formulations improved the bioaccessibility of different phenolics following in vitro GI digestion, leading to increased antioxidant and antimicrobial activities.
33321615	10	3	theme	junction	1547:1554	arg1	occludin					1564:1571	the tight junction protein occludin	1537:1571	the tight junction protein occludin	1537:1571	Confocal microscopy images confirmed the adsorption of NPs to the cellular layer and suggested a reduction of the tight junction protein occludin when cells were incubated with Cy5.5-CS in solution.
33321615	7	4	dep	in	1074:1075	arg1	vitro					1077:1081	vitro	1077:1081	vitro	1077:1081	Both formulations improved the bioaccessibility of different phenolics following in vitro GI digestion, leading to increased antioxidant and antimicrobial activities.
33321615	11	5	theme	oral	1784:1787	arg1	applications					1798:1809	oral delivery applications	1784:1809	oral delivery applications	1784:1809	This study suggests that encapsulation of GPE can offer protection against along the GI tract and improve its biological activity with significant impact for oral delivery applications, including functional foods.
33321615	11	5	theme	oral	1784:1787	arg1	foods					1833:1837	functional foods	1822:1837	functional foods	1822:1837	This study suggests that encapsulation of GPE can offer protection against along the GI tract and improve its biological activity with significant impact for oral delivery applications, including functional foods.
33321615	3	6	theme	alginate	440:447	arg1	NPs					470:472	NPs	470:472	NPs	470:472	This work aimed to encapsulate bioactive GP extract (GPE) into chitosan (CS) and alginate (Alg) nanoparticles (NPs) to mitigate degradation in the GI tract.
33321615	3	6	theme	alginate	440:447	arg1	nanoparticles					455:467	chitosan (CS) and alginate (Alg) nanoparticles	422:467	chitosan (CS) and alginate (Alg) nanoparticles (NPs)	422:473	This work aimed to encapsulate bioactive GP extract (GPE) into chitosan (CS) and alginate (Alg) nanoparticles (NPs) to mitigate degradation in the GI tract.
33321615	9	7	used	used	1323:1326	arg2	Cy5.5					1313:1317	Cy5.5	1313:1317	Cy5.5	1313:1317	Cy5.5 was used for tracking the CS NPs, which did not affect the metabolic activity of Caco-2 and HT29-MTX cells.
33321615	1	8	dep	gastrointestinal	246:261	arg1	GI					264:265	GI	264:265	GI	264:265	Grape pomace (GP) is a major by-product from the wine industry, known for its bioactive compounds and their impact upon gastrointestinal (GI) health.
33321615	11	9	theme	functional	1822:1831	arg1	foods					1833:1837	functional foods	1822:1837	functional foods	1822:1837	This study suggests that encapsulation of GPE can offer protection against along the GI tract and improve its biological activity with significant impact for oral delivery applications, including functional foods.
33321615	4	10	theme	rotatable	554:562	arg1	design					582:587	a rotatable central composite design	552:587	a rotatable central composite design	552:587	Alg and CS NPs were optimized using a rotatable central composite design and NPs were characterized for their size, polydispersity, zeta potential and total phenolics (TP) association efficiency.
33321615	11	11	theme	GPE	1668:1670	arg1	encapsulation					1651:1663	encapsulation	1651:1663	encapsulation of GPE	1651:1670	This study suggests that encapsulation of GPE can offer protection against along the GI tract and improve its biological activity with significant impact for oral delivery applications, including functional foods.
33321615	5	12	theme	TP	840:841	arg1	efficiencies					855:866	TP association efficiencies	840:866	TP association efficiencies of 68 and 65%	840:880	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	9	13	theme	CS	1345:1346	arg1	NPs					1348:1350	the CS NPs	1341:1350	the CS NPs	1341:1350	Cy5.5 was used for tracking the CS NPs, which did not affect the metabolic activity of Caco-2 and HT29-MTX cells.
33321615	0	14	theme	biological	103:112	arg1	activities					114:123	biological activities	103:123	biological activities	103:123	Polymeric nanoparticles as oral delivery systems for a grape pomace extract towards the improvement of biological activities.
33321615	6	15	theme	chemical	933:940	arg1	groups					942:947	new chemical groups	929:947	new chemical groups	929:947	FTIR confirmed that there was no formation of new chemical groups after association of the polymers with GPE.
33321615	8	16	theme	residence	1280:1288	arg1	time					1290:1293	a higher residence time	1271:1293	a higher residence time in the intestine	1271:1310	Moreover, the permeability of bioactive compounds through a Caco-2/HT29-MTX co-culture was reduced, suggesting a higher residence time in the intestine.
33321615	5	17	theme	polydispersity	767:780	arg1	indexes					782:788	polydispersity indexes	767:788	polydispersity indexes of 0.11-0.36	767:801	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	3	18	theme	GP	400:401	arg1	GPE					412:414	GPE	412:414	GPE	412:414	This work aimed to encapsulate bioactive GP extract (GPE) into chitosan (CS) and alginate (Alg) nanoparticles (NPs) to mitigate degradation in the GI tract.
33321615	3	18	theme	GP	400:401	arg1	extract					403:409	bioactive GP extract	390:409	bioactive GP extract (GPE)	390:415	This work aimed to encapsulate bioactive GP extract (GPE) into chitosan (CS) and alginate (Alg) nanoparticles (NPs) to mitigate degradation in the GI tract.
33321615	8	19	theme	higher	1273:1278	arg1	time					1290:1293	a higher residence time	1271:1293	a higher residence time in the intestine	1271:1310	Moreover, the permeability of bioactive compounds through a Caco-2/HT29-MTX co-culture was reduced, suggesting a higher residence time in the intestine.
33321615	4	20	theme	total	667:671	arg1	TP					684:685	TP	684:685	TP	684:685	Alg and CS NPs were optimized using a rotatable central composite design and NPs were characterized for their size, polydispersity, zeta potential and total phenolics (TP) association efficiency.
33321615	4	20	theme	total	667:671	arg1	phenolics					673:681	total phenolics	667:681	total phenolics (TP)	667:686	Alg and CS NPs were optimized using a rotatable central composite design and NPs were characterized for their size, polydispersity, zeta potential and total phenolics (TP) association efficiency.
33321615	6	21	theme	polymers	974:981	arg1	association					955:965	association	955:965	association of the polymers with GPE	955:990	FTIR confirmed that there was no formation of new chemical groups after association of the polymers with GPE.
33321615	1	22	theme	major	149:153	arg1	by-product					155:164	a major by-product	147:164	a major by-product	147:164	Grape pomace (GP) is a major by-product from the wine industry, known for its bioactive compounds and their impact upon gastrointestinal (GI) health.
33321615	1	22	theme	major	149:153	arg1	pomace					132:137	Grape pomace	126:137	Grape pomace (GP)	126:142	Grape pomace (GP) is a major by-product from the wine industry, known for its bioactive compounds and their impact upon gastrointestinal (GI) health.
33321615	8	23	theme	Caco-2/HT29-MTX	1220:1234	arg1	co-culture					1236:1245	a Caco-2/HT29-MTX co-culture	1218:1245	a Caco-2/HT29-MTX co-culture	1218:1245	Moreover, the permeability of bioactive compounds through a Caco-2/HT29-MTX co-culture was reduced, suggesting a higher residence time in the intestine.
33321615	10	24	theme	microscopy	1436:1445	arg1	images					1447:1452	Confocal microscopy images	1427:1452	Confocal microscopy images	1427:1452	Confocal microscopy images confirmed the adsorption of NPs to the cellular layer and suggested a reduction of the tight junction protein occludin when cells were incubated with Cy5.5-CS in solution.
33321615	10	25	theme	NPs	1482:1484	arg1	adsorption					1468:1477	the adsorption	1464:1477	the adsorption of NPs to the cellular layer	1464:1506	Confocal microscopy images confirmed the adsorption of NPs to the cellular layer and suggested a reduction of the tight junction protein occludin when cells were incubated with Cy5.5-CS in solution.
33321615	4	26	dep	size	626:629	arg1	efficiency					700:709	association efficiency	688:709	association efficiency	688:709	Alg and CS NPs were optimized using a rotatable central composite design and NPs were characterized for their size, polydispersity, zeta potential and total phenolics (TP) association efficiency.
33321615	4	27	theme	composite	572:580	arg1	design					582:587	a rotatable central composite design	552:587	a rotatable central composite design	552:587	Alg and CS NPs were optimized using a rotatable central composite design and NPs were characterized for their size, polydispersity, zeta potential and total phenolics (TP) association efficiency.
33321615	7	28	theme	GI	1083:1084	arg1	digestion					1086:1094	in vitro GI digestion	1074:1094	in vitro GI digestion	1074:1094	Both formulations improved the bioaccessibility of different phenolics following in vitro GI digestion, leading to increased antioxidant and antimicrobial activities.
33321615	5	29	theme	association	843:853	arg1	efficiencies					855:866	TP association efficiencies	840:866	TP association efficiencies of 68 and 65%	840:880	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	3	30	theme	bioactive	390:398	arg1	GPE					412:414	GPE	412:414	GPE	412:414	This work aimed to encapsulate bioactive GP extract (GPE) into chitosan (CS) and alginate (Alg) nanoparticles (NPs) to mitigate degradation in the GI tract.
33321615	3	30	theme	bioactive	390:398	arg1	extract					403:409	bioactive GP extract	390:409	bioactive GP extract (GPE)	390:415	This work aimed to encapsulate bioactive GP extract (GPE) into chitosan (CS) and alginate (Alg) nanoparticles (NPs) to mitigate degradation in the GI tract.
33321615	0	31	theme	oral	27:30	arg1	systems					41:47	oral delivery systems	27:47	oral delivery systems for a grape pomace extract	27:74	Polymeric nanoparticles as oral delivery systems for a grape pomace extract towards the improvement of biological activities.
33321615	1	32	theme	gastrointestinal	246:261	arg1	health					268:273	gastrointestinal (GI) health	246:273	gastrointestinal (GI) health	246:273	Grape pomace (GP) is a major by-product from the wine industry, known for its bioactive compounds and their impact upon gastrointestinal (GI) health.
33321615	10	33	theme	tight	1541:1545	arg1	occludin					1564:1571	the tight junction protein occludin	1537:1571	the tight junction protein occludin	1537:1571	Confocal microscopy images confirmed the adsorption of NPs to the cellular layer and suggested a reduction of the tight junction protein occludin when cells were incubated with Cy5.5-CS in solution.
33321615	4	34	theme	zeta	648:651	arg1	potential					653:661	zeta potential	648:661	zeta potential	648:661	Alg and CS NPs were optimized using a rotatable central composite design and NPs were characterized for their size, polydispersity, zeta potential and total phenolics (TP) association efficiency.
33321615	6	35	theme	groups	942:947	arg1	formation					916:924	no formation	913:924	no formation of new chemical groups	913:947	FTIR confirmed that there was no formation of new chemical groups after association of the polymers with GPE.
33321615	5	36	theme	best	716:719	arg1	formulations					721:732	The best formulations	712:732	The best formulations	712:732	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	0	37	theme	activities	114:123	arg1	improvement					88:98	the improvement	84:98	the improvement of biological activities	84:123	Polymeric nanoparticles as oral delivery systems for a grape pomace extract towards the improvement of biological activities.
33321615	6	38	with	association	955:965	arg1	GPE					988:990	GPE	988:990	GPE	988:990	FTIR confirmed that there was no formation of new chemical groups after association of the polymers with GPE.
33321615	5	39	theme	zeta	804:807	arg1	potential					809:817	zeta potential	804:817	zeta potential of -15.0-14.9 mV	804:834	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	1	40	theme	wine	175:178	arg1	industry					180:187	the wine industry	171:187	the wine industry	171:187	Grape pomace (GP) is a major by-product from the wine industry, known for its bioactive compounds and their impact upon gastrointestinal (GI) health.
33321615	7	41	theme	different	1044:1052	arg1	phenolics					1054:1062	different phenolics	1044:1062	different phenolics	1044:1062	Both formulations improved the bioaccessibility of different phenolics following in vitro GI digestion, leading to increased antioxidant and antimicrobial activities.
33321615	8	42	theme	compounds	1200:1208	arg1	permeability					1174:1185	the permeability	1170:1185	the permeability of bioactive compounds through a Caco-2/HT29-MTX co-culture	1170:1245	Moreover, the permeability of bioactive compounds through a Caco-2/HT29-MTX co-culture was reduced, suggesting a higher residence time in the intestine.
33321615	8	43	theme	bioactive	1190:1198	arg1	compounds					1200:1208	bioactive compounds	1190:1208	bioactive compounds	1190:1208	Moreover, the permeability of bioactive compounds through a Caco-2/HT29-MTX co-culture was reduced, suggesting a higher residence time in the intestine.
33321615	3	44	theme	GI	506:507	arg1	tract					509:513	the GI tract	502:513	the GI tract	502:513	This work aimed to encapsulate bioactive GP extract (GPE) into chitosan (CS) and alginate (Alg) nanoparticles (NPs) to mitigate degradation in the GI tract.
33321615	4	45	theme	central	564:570	arg1	design					582:587	a rotatable central composite design	552:587	a rotatable central composite design	552:587	Alg and CS NPs were optimized using a rotatable central composite design and NPs were characterized for their size, polydispersity, zeta potential and total phenolics (TP) association efficiency.
33321615	6	46	theme	new	929:931	arg1	groups					942:947	new chemical groups	929:947	new chemical groups	929:947	FTIR confirmed that there was no formation of new chemical groups after association of the polymers with GPE.
33321615	0	47	theme	delivery	32:39	arg1	systems					41:47	oral delivery systems	27:47	oral delivery systems for a grape pomace extract	27:74	Polymeric nanoparticles as oral delivery systems for a grape pomace extract towards the improvement of biological activities.
33321615	7	48	theme	phenolics	1054:1062	arg1	bioaccessibility					1024:1039	the bioaccessibility	1020:1039	the bioaccessibility of different phenolics	1020:1062	Both formulations improved the bioaccessibility of different phenolics following in vitro GI digestion, leading to increased antioxidant and antimicrobial activities.
33321615	10	49	theme	cellular	1493:1500	arg1	layer					1502:1506	the cellular layer	1489:1506	the cellular layer	1489:1506	Confocal microscopy images confirmed the adsorption of NPs to the cellular layer and suggested a reduction of the tight junction protein occludin when cells were incubated with Cy5.5-CS in solution.
33321615	1	50	from	industry	180:187	arg1	by-product					155:164	a major by-product	147:164	a major by-product	147:164	Grape pomace (GP) is a major by-product from the wine industry, known for its bioactive compounds and their impact upon gastrointestinal (GI) health.
33321615	1	50	from	industry	180:187	arg1	pomace					132:137	Grape pomace	126:137	Grape pomace (GP)	126:142	Grape pomace (GP) is a major by-product from the wine industry, known for its bioactive compounds and their impact upon gastrointestinal (GI) health.
33321615	9	51	theme	metabolic	1378:1386	arg1	activity					1388:1395	the metabolic activity	1374:1395	the metabolic activity of Caco-2 and HT29-MTX cells	1374:1424	Cy5.5 was used for tracking the CS NPs, which did not affect the metabolic activity of Caco-2 and HT29-MTX cells.
33321615	10	52	theme	Confocal	1427:1434	arg1	microscopy					1436:1445	Confocal microscopy	1427:1445	Confocal microscopy images	1427:1452	Confocal microscopy images confirmed the adsorption of NPs to the cellular layer and suggested a reduction of the tight junction protein occludin when cells were incubated with Cy5.5-CS in solution.
33321615	7	53	theme	antimicrobial	1134:1146	arg1	activities					1148:1157	increased antioxidant and antimicrobial activities	1108:1157	increased antioxidant and antimicrobial activities	1108:1157	Both formulations improved the bioaccessibility of different phenolics following in vitro GI digestion, leading to increased antioxidant and antimicrobial activities.
33321615	11	54	theme	delivery	1789:1796	arg1	applications					1798:1809	oral delivery applications	1784:1809	oral delivery applications	1784:1809	This study suggests that encapsulation of GPE can offer protection against along the GI tract and improve its biological activity with significant impact for oral delivery applications, including functional foods.
33321615	11	54	theme	delivery	1789:1796	arg1	foods					1833:1837	functional foods	1822:1837	functional foods	1822:1837	This study suggests that encapsulation of GPE can offer protection against along the GI tract and improve its biological activity with significant impact for oral delivery applications, including functional foods.
33321615	11	55	with	activity	1747:1754	arg1	impact					1773:1778	significant impact	1761:1778	significant impact for oral delivery applications, including functional foods	1761:1837	This study suggests that encapsulation of GPE can offer protection against along the GI tract and improve its biological activity with significant impact for oral delivery applications, including functional foods.
33321615	10	56	theme	protein	1556:1562	arg1	occludin					1564:1571	the tight junction protein occludin	1537:1571	the tight junction protein occludin	1537:1571	Confocal microscopy images confirmed the adsorption of NPs to the cellular layer and suggested a reduction of the tight junction protein occludin when cells were incubated with Cy5.5-CS in solution.
33321615	5	57	theme	-15.0-14.9 mV	822:834	arg1	sizes					741:745	sizes	741:745	sizes ranging 523-853 nm	741:764	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	5	57	theme	-15.0-14.9 mV	822:834	arg1	efficiencies					855:866	TP association efficiencies	840:866	TP association efficiencies of 68 and 65%	840:880	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	5	57	theme	-15.0-14.9 mV	822:834	arg1	potential					809:817	zeta potential	804:817	zeta potential of -15.0-14.9 mV	804:834	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	5	57	theme	-15.0-14.9 mV	822:834	arg1	indexes					782:788	polydispersity indexes	767:788	polydispersity indexes of 0.11-0.36	767:801	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	11	58	theme	significant	1761:1771	arg1	impact					1773:1778	significant impact	1761:1778	significant impact for oral delivery applications, including functional foods	1761:1837	This study suggests that encapsulation of GPE can offer protection against along the GI tract and improve its biological activity with significant impact for oral delivery applications, including functional foods.
33321615	1	59	theme	Grape	126:130	arg1	by-product					155:164	a major by-product	147:164	a major by-product	147:164	Grape pomace (GP) is a major by-product from the wine industry, known for its bioactive compounds and their impact upon gastrointestinal (GI) health.
33321615	1	59	theme	Grape	126:130	arg1	GP					140:141	GP	140:141	GP	140:141	Grape pomace (GP) is a major by-product from the wine industry, known for its bioactive compounds and their impact upon gastrointestinal (GI) health.
33321615	1	59	theme	Grape	126:130	arg1	pomace					132:137	Grape pomace	126:137	Grape pomace (GP)	126:142	Grape pomace (GP) is a major by-product from the wine industry, known for its bioactive compounds and their impact upon gastrointestinal (GI) health.
33321615	4	60	theme	Alg	516:518	arg1	NPs					527:529	Alg and CS NPs	516:529	Alg and CS NPs	516:529	Alg and CS NPs were optimized using a rotatable central composite design and NPs were characterized for their size, polydispersity, zeta potential and total phenolics (TP) association efficiency.
33321615	5	61	theme	%	880:880	arg1	sizes					741:745	sizes	741:745	sizes ranging 523-853 nm	741:764	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	5	61	theme	%	880:880	arg1	efficiencies					855:866	TP association efficiencies	840:866	TP association efficiencies of 68 and 65%	840:880	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	5	61	theme	%	880:880	arg1	potential					809:817	zeta potential	804:817	zeta potential of -15.0-14.9 mV	804:834	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	5	61	theme	%	880:880	arg1	indexes					782:788	polydispersity indexes	767:788	polydispersity indexes of 0.11-0.36	767:801	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	11	62	theme	GI	1711:1712	arg1	tract					1714:1718	the GI tract	1707:1718	the GI tract	1707:1718	This study suggests that encapsulation of GPE can offer protection against along the GI tract and improve its biological activity with significant impact for oral delivery applications, including functional foods.
33321615	10	63	theme	occludin	1564:1571	arg1	reduction					1524:1532	a reduction	1522:1532	a reduction of the tight junction protein occludin when cells were incubated with Cy5.5-CS in solution	1522:1623	Confocal microscopy images confirmed the adsorption of NPs to the cellular layer and suggested a reduction of the tight junction protein occludin when cells were incubated with Cy5.5-CS in solution.
33321615	9	64	theme	cells	1420:1424	arg1	activity					1388:1395	the metabolic activity	1374:1395	the metabolic activity of Caco-2 and HT29-MTX cells	1374:1424	Cy5.5 was used for tracking the CS NPs, which did not affect the metabolic activity of Caco-2 and HT29-MTX cells.
33321615	3	65	theme	chitosan	422:429	arg1	NPs					470:472	NPs	470:472	NPs	470:472	This work aimed to encapsulate bioactive GP extract (GPE) into chitosan (CS) and alginate (Alg) nanoparticles (NPs) to mitigate degradation in the GI tract.
33321615	3	65	theme	chitosan	422:429	arg1	nanoparticles					455:467	chitosan (CS) and alginate (Alg) nanoparticles	422:467	chitosan (CS) and alginate (Alg) nanoparticles (NPs)	422:473	This work aimed to encapsulate bioactive GP extract (GPE) into chitosan (CS) and alginate (Alg) nanoparticles (NPs) to mitigate degradation in the GI tract.
33321615	0	66	theme	pomace	61:66	arg1	extract					68:74	a grape pomace extract	53:74	a grape pomace extract	53:74	Polymeric nanoparticles as oral delivery systems for a grape pomace extract towards the improvement of biological activities.
33321615	8	67	from	time	1290:1293	arg1	intestine					1302:1310	the intestine	1298:1310	the intestine	1298:1310	Moreover, the permeability of bioactive compounds through a Caco-2/HT29-MTX co-culture was reduced, suggesting a higher residence time in the intestine.
33321615	4	68	theme	association	688:698	arg1	efficiency					700:709	association efficiency	688:709	association efficiency	688:709	Alg and CS NPs were optimized using a rotatable central composite design and NPs were characterized for their size, polydispersity, zeta potential and total phenolics (TP) association efficiency.
33321615	9	69	theme	HT29-MTX	1411:1418	arg1	cells					1420:1424	Caco-2 and HT29-MTX cells	1400:1424	Caco-2 and HT29-MTX cells	1400:1424	Cy5.5 was used for tracking the CS NPs, which did not affect the metabolic activity of Caco-2 and HT29-MTX cells.
33321615	3	70	from	degradation	487:497	arg1	tract					509:513	the GI tract	502:513	the GI tract	502:513	This work aimed to encapsulate bioactive GP extract (GPE) into chitosan (CS) and alginate (Alg) nanoparticles (NPs) to mitigate degradation in the GI tract.
33321615	4	71	theme	CS	524:525	arg1	NPs					527:529	Alg and CS NPs	516:529	Alg and CS NPs	516:529	Alg and CS NPs were optimized using a rotatable central composite design and NPs were characterized for their size, polydispersity, zeta potential and total phenolics (TP) association efficiency.
33321615	0	72	theme	grape	55:59	arg1	extract					68:74	a grape pomace extract	53:74	a grape pomace extract	53:74	Polymeric nanoparticles as oral delivery systems for a grape pomace extract towards the improvement of biological activities.
33321615	7	73	theme	in	1074:1075	arg1	digestion					1086:1094	in vitro GI digestion	1074:1094	in vitro GI digestion	1074:1094	Both formulations improved the bioaccessibility of different phenolics following in vitro GI digestion, leading to increased antioxidant and antimicrobial activities.
33321615	5	74	theme	0.11-0.36	793:801	arg1	sizes					741:745	sizes	741:745	sizes ranging 523-853 nm	741:764	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	5	74	theme	0.11-0.36	793:801	arg1	efficiencies					855:866	TP association efficiencies	840:866	TP association efficiencies of 68 and 65%	840:880	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	5	74	theme	0.11-0.36	793:801	arg1	potential					809:817	zeta potential	804:817	zeta potential of -15.0-14.9 mV	804:834	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	5	74	theme	0.11-0.36	793:801	arg1	indexes					782:788	polydispersity indexes	767:788	polydispersity indexes of 0.11-0.36	767:801	The best formulations showed sizes ranging 523-853 nm, polydispersity indexes of 0.11-0.36, zeta potential of -15.0-14.9 mV and TP association efficiencies of 68 and 65%.
33321615	11	75	theme	biological	1736:1745	arg1	activity					1747:1754	its biological activity	1732:1754	its biological activity with significant impact for oral delivery applications, including functional foods	1732:1837	This study suggests that encapsulation of GPE can offer protection against along the GI tract and improve its biological activity with significant impact for oral delivery applications, including functional foods.
33321615	1	76	theme	bioactive	204:212	arg1	compounds					214:222	its bioactive compounds	200:222	its bioactive compounds	200:222	Grape pomace (GP) is a major by-product from the wine industry, known for its bioactive compounds and their impact upon gastrointestinal (GI) health.
32980603	9	0	theme	simultaneous	1581:1592	arg1	removal/recovery					1596:1611	simultaneous P removal/recovery	1581:1611	simultaneous P removal/recovery	1581:1611	As the P-loaded CTS-Fe particles can be easily separated and recovered from the AD system and further reutilized in agriculture, this study could provide a new approach for simultaneous P removal/recovery and enhanced methane production from AD of WAS.
32980603	1	1	theme	anaerobic	290:298	arg1	digestion					300:308	anaerobic digestion	290:308	anaerobic digestion (AD)	290:313	Fe(III)-loaded chitosan (CTS-Fe) composite was used for the first time to remove and recover phosphorus (P) from waste activated sludge (WAS) via anaerobic digestion (AD).
32980603	1	1	theme	anaerobic	290:298	arg1	AD					311:312	AD	311:312	AD	311:312	Fe(III)-loaded chitosan (CTS-Fe) composite was used for the first time to remove and recover phosphorus (P) from waste activated sludge (WAS) via anaerobic digestion (AD).
32980603	6	2	from	Fe	936:937	arg1	CTS-Fe					951:956	the CTS-Fe	947:956	the CTS-Fe	947:956	Notably, partial Fe(III) on the CTS-Fe was reduced and effectively combined with P to form vivianite crystals on the CTS-Fe surface during the AD process.
32980603	1	3	theme	chitosan	159:166	arg1	composite					177:185	Fe(III)-loaded chitosan (CTS-Fe) composite	144:185	Fe(III)-loaded chitosan (CTS-Fe) composite	144:185	Fe(III)-loaded chitosan (CTS-Fe) composite was used for the first time to remove and recover phosphorus (P) from waste activated sludge (WAS) via anaerobic digestion (AD).
32980603	9	4	from	AD	1650:1651	arg1	production					1634:1643	enhanced methane production	1617:1643	enhanced methane production from AD of WAS	1617:1658	As the P-loaded CTS-Fe particles can be easily separated and recovered from the AD system and further reutilized in agriculture, this study could provide a new approach for simultaneous P removal/recovery and enhanced methane production from AD of WAS.
32980603	9	4	from	AD	1650:1651	arg1	removal/recovery					1596:1611	simultaneous P removal/recovery	1581:1611	simultaneous P removal/recovery	1581:1611	As the P-loaded CTS-Fe particles can be easily separated and recovered from the AD system and further reutilized in agriculture, this study could provide a new approach for simultaneous P removal/recovery and enhanced methane production from AD of WAS.
32980603	0	5	theme	waste	87:91	arg1	production					73:82	enhanced methane production	56:82	enhanced methane production of waste	56:91	Insight into efficient phosphorus removal/recovery from enhanced methane production of waste activated sludge with chitosan-Fe supplementation.
32980603	4	6	from	reduction	751:759	arg1	sludge					791:796	the sludge	787:796	the sludge with phosphate released into the liquid phase	787:842	This is probably brought about by the added CTS-Fe enhanced the reduction of Fe(III)-P compounds in the sludge with phosphate released into the liquid phase.
32980603	5	7	theme	liquid	894:899	arg1	digestate					901:909	the liquid digestate	890:909	the liquid digestate of WAS	890:916	CTS-Fe can efficiently recover 95% of P from the liquid digestate of WAS.
32980603	3	8	theme	fractionation	446:458	arg1	results					460:466	The P fractionation results	440:466	The P fractionation results	440:466	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	8	9	theme	attributable	1331:1342	arg1	conditions					1312:1321	the tested conditions	1301:1321	the tested conditions	1301:1321	Furthermore, the addition of CTS-Fe increased methane production by 11.9 - 32.2% under the tested conditions, likely attributable to the enhanced hydrolysis of WAS under CTS-Fe supplementation.
32980603	3	10	from	g/L	567:569	arg1	sludge					554:559	sludge	554:559	sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS)	554:603	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	3	10	from	g/L	567:569	arg1	phase					545:549	the solid phase	535:549	the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS)	535:603	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	3	11	theme	2.4	609:611	arg1	times					613:617	times	613:617	times	613:617	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	1	12	from	sludge	273:278	arg1	phosphorus					237:246	phosphorus	237:246	phosphorus (P) from waste activated sludge	237:278	Fe(III)-loaded chitosan (CTS-Fe) composite was used for the first time to remove and recover phosphorus (P) from waste activated sludge (WAS) via anaerobic digestion (AD).
32980603	1	12	from	sludge	273:278	arg1	P					249:249	P	249:249	P	249:249	Fe(III)-loaded chitosan (CTS-Fe) composite was used for the first time to remove and recover phosphorus (P) from waste activated sludge (WAS) via anaerobic digestion (AD).
32980603	3	13	theme	inorganic	494:502	arg1	NAIP					516:519	NAIP	516:519	NAIP	516:519	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	3	13	theme	inorganic	494:502	arg1	phosphorus					504:513	inorganic phosphorus	494:513	non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS)	482:603	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	8	14	theme	enhanced	1351:1358	arg1	hydrolysis					1360:1369	the enhanced hydrolysis	1347:1369	the enhanced hydrolysis of WAS under CTS-Fe supplementation	1347:1405	Furthermore, the addition of CTS-Fe increased methane production by 11.9 - 32.2% under the tested conditions, likely attributable to the enhanced hydrolysis of WAS under CTS-Fe supplementation.
32980603	3	15	theme	phosphorus	504:513	arg1	reduction					522:530	non-apatite inorganic phosphorus (NAIP) reduction	482:530	non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS)	482:603	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	4	16	with	sludge	791:796	arg1	phosphate					803:811	phosphate	803:811	phosphate released into the liquid phase	803:842	This is probably brought about by the added CTS-Fe enhanced the reduction of Fe(III)-P compounds in the sludge with phosphate released into the liquid phase.
32980603	9	17	theme	enhanced	1617:1624	arg1	production					1634:1643	enhanced methane production	1617:1643	enhanced methane production from AD of WAS	1617:1658	As the P-loaded CTS-Fe particles can be easily separated and recovered from the AD system and further reutilized in agriculture, this study could provide a new approach for simultaneous P removal/recovery and enhanced methane production from AD of WAS.
32980603	4	18	theme	added	725:729	arg1	CTS-Fe					731:736	the added CTS-Fe	721:736	the added CTS-Fe	721:736	This is probably brought about by the added CTS-Fe enhanced the reduction of Fe(III)-P compounds in the sludge with phosphate released into the liquid phase.
32980603	6	19	theme	partial	928:934	arg1	Fe					936:937	partial Fe	928:937	partial Fe(III) on the CTS-Fe	928:956	Notably, partial Fe(III) on the CTS-Fe was reduced and effectively combined with P to form vivianite crystals on the CTS-Fe surface during the AD process.
32980603	6	19	theme	partial	928:934	arg1	III					939:941	III	939:941	III	939:941	Notably, partial Fe(III) on the CTS-Fe was reduced and effectively combined with P to form vivianite crystals on the CTS-Fe surface during the AD process.
32980603	7	20	theme	chemical	1138:1145	arg1	exchange					1125:1132	ligand exchange	1118:1132	ligand exchange	1118:1132	Characterization analysis demonstrated that ligand exchange and chemical precipitation were the dominant mechanisms for P removal/recovery.
32980603	7	20	theme	chemical	1138:1145	arg1	precipitation					1147:1159	chemical precipitation	1138:1159	chemical precipitation	1138:1159	Characterization analysis demonstrated that ligand exchange and chemical precipitation were the dominant mechanisms for P removal/recovery.
32980603	7	20	theme	chemical	1138:1145	arg1	mechanisms					1179:1188	the dominant mechanisms	1166:1188	the dominant mechanisms for P removal/recovery	1166:1211	Characterization analysis demonstrated that ligand exchange and chemical precipitation were the dominant mechanisms for P removal/recovery.
32980603	1	21	theme	CTS-Fe	169:174	arg1	composite					177:185	Fe(III)-loaded chitosan (CTS-Fe) composite	144:185	Fe(III)-loaded chitosan (CTS-Fe) composite	144:185	Fe(III)-loaded chitosan (CTS-Fe) composite was used for the first time to remove and recover phosphorus (P) from waste activated sludge (WAS) via anaerobic digestion (AD).
32980603	0	22	theme	chitosan-Fe	115:125	arg1	supplementation					127:141	chitosan-Fe supplementation	115:141	chitosan-Fe supplementation	115:141	Insight into efficient phosphorus removal/recovery from enhanced methane production of waste activated sludge with chitosan-Fe supplementation.
32980603	6	23	theme	AD	1062:1063	arg1	process					1065:1071	the AD process	1058:1071	the AD process	1058:1071	Notably, partial Fe(III) on the CTS-Fe was reduced and effectively combined with P to form vivianite crystals on the CTS-Fe surface during the AD process.
32980603	3	24	theme	non-apatite	482:492	arg1	reduction					522:530	non-apatite inorganic phosphorus (NAIP) reduction	482:530	non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS)	482:603	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	2	25	theme	AD	386:387	arg1	process					389:395	the AD process	382:395	the AD process	382:395	The P transformation pathway and the effect of CTS-Fe addition on the AD process were investigated using batch experiments.
32980603	2	26	theme	batch	421:425	arg1	experiments					427:437	batch experiments	421:437	batch experiments	421:437	The P transformation pathway and the effect of CTS-Fe addition on the AD process were investigated using batch experiments.
32980603	2	27	theme	transformation	322:335	arg1	pathway					337:343	The P transformation pathway	316:343	The P transformation pathway	316:343	The P transformation pathway and the effect of CTS-Fe addition on the AD process were investigated using batch experiments.
32980603	8	28	theme	tested	1305:1310	arg1	conditions					1312:1321	the tested conditions	1301:1321	the tested conditions	1301:1321	Furthermore, the addition of CTS-Fe increased methane production by 11.9 - 32.2% under the tested conditions, likely attributable to the enhanced hydrolysis of WAS under CTS-Fe supplementation.
32980603	5	29	theme	WAS	914:916	arg1	digestate					901:909	the liquid digestate	890:909	the liquid digestate of WAS	890:916	CTS-Fe can efficiently recover 95% of P from the liquid digestate of WAS.
32980603	9	30	theme	WAS	1656:1658	arg1	production					1634:1643	enhanced methane production	1617:1643	enhanced methane production from AD of WAS	1617:1658	As the P-loaded CTS-Fe particles can be easily separated and recovered from the AD system and further reutilized in agriculture, this study could provide a new approach for simultaneous P removal/recovery and enhanced methane production from AD of WAS.
32980603	9	30	theme	WAS	1656:1658	arg1	removal/recovery					1596:1611	simultaneous P removal/recovery	1581:1611	simultaneous P removal/recovery	1581:1611	As the P-loaded CTS-Fe particles can be easily separated and recovered from the AD system and further reutilized in agriculture, this study could provide a new approach for simultaneous P removal/recovery and enhanced methane production from AD of WAS.
32980603	2	31	theme	P	320:320	arg1	pathway					337:343	The P transformation pathway	316:343	The P transformation pathway	316:343	The P transformation pathway and the effect of CTS-Fe addition on the AD process were investigated using batch experiments.
32980603	0	32	theme	phosphorus	23:32	arg1	removal/recovery					34:49	efficient phosphorus removal/recovery	13:49	efficient phosphorus removal/recovery from enhanced methane production of waste	13:91	Insight into efficient phosphorus removal/recovery from enhanced methane production of waste activated sludge with chitosan-Fe supplementation.
32980603	9	33	theme	P	1594:1594	arg1	removal/recovery					1596:1611	simultaneous P removal/recovery	1581:1611	simultaneous P removal/recovery	1581:1611	As the P-loaded CTS-Fe particles can be easily separated and recovered from the AD system and further reutilized in agriculture, this study could provide a new approach for simultaneous P removal/recovery and enhanced methane production from AD of WAS.
32980603	5	34	theme	P	883:883	arg1	%					878:878	95%	876:878	95% of P	876:883	CTS-Fe can efficiently recover 95% of P from the liquid digestate of WAS.
32980603	5	34	theme	P	883:883	arg1	P					883:883	P	883:883	P	883:883	CTS-Fe can efficiently recover 95% of P from the liquid digestate of WAS.
32980603	9	35	theme	CTS-Fe	1424:1429	arg1	particles					1431:1439	the P-loaded CTS-Fe particles	1411:1439	the P-loaded CTS-Fe particles	1411:1439	As the P-loaded CTS-Fe particles can be easily separated and recovered from the AD system and further reutilized in agriculture, this study could provide a new approach for simultaneous P removal/recovery and enhanced methane production from AD of WAS.
32980603	2	36	theme	CTS-Fe	363:368	arg1	addition					370:377	CTS-Fe addition	363:377	CTS-Fe addition	363:377	The P transformation pathway and the effect of CTS-Fe addition on the AD process were investigated using batch experiments.
32980603	0	37	theme	efficient	13:21	arg1	removal/recovery					34:49	efficient phosphorus removal/recovery	13:49	efficient phosphorus removal/recovery from enhanced methane production of waste	13:91	Insight into efficient phosphorus removal/recovery from enhanced methane production of waste activated sludge with chitosan-Fe supplementation.
32980603	1	38	theme	waste	257:261	arg1	sludge					273:278	waste activated sludge	257:278	waste activated sludge	257:278	Fe(III)-loaded chitosan (CTS-Fe) composite was used for the first time to remove and recover phosphorus (P) from waste activated sludge (WAS) via anaerobic digestion (AD).
32980603	4	39	theme	compounds	774:782	arg1	reduction					751:759	the reduction	747:759	the reduction of Fe(III)-P compounds in the sludge with phosphate released into the liquid phase	747:842	This is probably brought about by the added CTS-Fe enhanced the reduction of Fe(III)-P compounds in the sludge with phosphate released into the liquid phase.
32980603	3	40	theme	CTS-Fe	574:579	arg1	addition					581:588	CTS-Fe addition	574:588	CTS-Fe addition (6.72 mg/g-SS)	574:603	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	3	40	theme	CTS-Fe	574:579	arg1	mg/g-SS					596:602	6.72 mg/g-SS	591:602	6.72 mg/g-SS	591:602	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	9	41	theme	P-loaded	1415:1422	arg1	particles					1431:1439	the P-loaded CTS-Fe particles	1411:1439	the P-loaded CTS-Fe particles	1411:1439	As the P-loaded CTS-Fe particles can be easily separated and recovered from the AD system and further reutilized in agriculture, this study could provide a new approach for simultaneous P removal/recovery and enhanced methane production from AD of WAS.
32980603	7	42	theme	P	1194:1194	arg1	removal/recovery					1196:1211	P removal/recovery	1194:1211	P removal/recovery	1194:1211	Characterization analysis demonstrated that ligand exchange and chemical precipitation were the dominant mechanisms for P removal/recovery.
32980603	3	43	theme	P	444:444	arg1	results					460:466	The P fractionation results	440:466	The P fractionation results	440:466	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	1	44	theme	activated	263:271	arg1	sludge					273:278	waste activated sludge	257:278	waste activated sludge	257:278	Fe(III)-loaded chitosan (CTS-Fe) composite was used for the first time to remove and recover phosphorus (P) from waste activated sludge (WAS) via anaerobic digestion (AD).
32980603	3	45	theme	addition	581:588	arg1	sludge					554:559	sludge	554:559	sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS)	554:603	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	3	46	theme	solid	539:543	arg1	phase					545:549	the solid phase	535:549	the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS)	535:603	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	3	47	from	phase	545:549	arg1	g/L					567:569	20 g/L	564:569	20 g/L	564:569	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	3	48	dep	times	613:617	arg1	higher					619:624	higher	619:624	higher	619:624	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	3	49	theme	CTS-Fe	669:674	arg1	mg/g-SS					657:663	2.77 mg/g-SS	652:663	2.77 mg/g-SS	652:663	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	3	49	theme	CTS-Fe	669:674	arg1	addition					676:683	no CTS-Fe addition	666:683	no CTS-Fe addition	666:683	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	6	50	theme	CTS-Fe	1036:1041	arg1	surface					1043:1049	the CTS-Fe surface	1032:1049	the CTS-Fe surface during the AD process	1032:1071	Notably, partial Fe(III) on the CTS-Fe was reduced and effectively combined with P to form vivianite crystals on the CTS-Fe surface during the AD process.
32980603	1	51	theme	first	204:208	arg1	time					210:213	the first time	200:213	the first time	200:213	Fe(III)-loaded chitosan (CTS-Fe) composite was used for the first time to remove and recover phosphorus (P) from waste activated sludge (WAS) via anaerobic digestion (AD).
32980603	0	52	theme	methane	65:71	arg1	production					73:82	enhanced methane production	56:82	enhanced methane production of waste	56:91	Insight into efficient phosphorus removal/recovery from enhanced methane production of waste activated sludge with chitosan-Fe supplementation.
32980603	4	53	theme	Fe	764:765	arg1	compounds					774:782	Fe(III)-P compounds	764:782	Fe(III)-P compounds	764:782	This is probably brought about by the added CTS-Fe enhanced the reduction of Fe(III)-P compounds in the sludge with phosphate released into the liquid phase.
32980603	0	54	from	production	73:82	arg1	removal/recovery					34:49	efficient phosphorus removal/recovery	13:49	efficient phosphorus removal/recovery from enhanced methane production of waste	13:91	Insight into efficient phosphorus removal/recovery from enhanced methane production of waste activated sludge with chitosan-Fe supplementation.
32980603	8	55	theme	CTS-Fe	1243:1248	arg1	addition					1231:1238	the addition	1227:1238	the addition of CTS-Fe	1227:1248	Furthermore, the addition of CTS-Fe increased methane production by 11.9 - 32.2% under the tested conditions, likely attributable to the enhanced hydrolysis of WAS under CTS-Fe supplementation.
32980603	0	56	theme	enhanced	56:63	arg1	production					73:82	enhanced methane production	56:82	enhanced methane production of waste	56:91	Insight into efficient phosphorus removal/recovery from enhanced methane production of waste activated sludge with chitosan-Fe supplementation.
32980603	8	57	theme	CTS-Fe	1384:1389	arg1	supplementation					1391:1405	CTS-Fe supplementation	1384:1405	CTS-Fe supplementation	1384:1405	Furthermore, the addition of CTS-Fe increased methane production by 11.9 - 32.2% under the tested conditions, likely attributable to the enhanced hydrolysis of WAS under CTS-Fe supplementation.
32980603	1	58	used	used	191:194	arg2	composite					177:185	Fe(III)-loaded chitosan (CTS-Fe) composite	144:185	Fe(III)-loaded chitosan (CTS-Fe) composite	144:185	Fe(III)-loaded chitosan (CTS-Fe) composite was used for the first time to remove and recover phosphorus (P) from waste activated sludge (WAS) via anaerobic digestion (AD).
32980603	9	59	theme	methane	1626:1632	arg1	production					1634:1643	enhanced methane production	1617:1643	enhanced methane production from AD of WAS	1617:1658	As the P-loaded CTS-Fe particles can be easily separated and recovered from the AD system and further reutilized in agriculture, this study could provide a new approach for simultaneous P removal/recovery and enhanced methane production from AD of WAS.
32980603	1	60	theme	Fe	144:145	arg1	composite					177:185	Fe(III)-loaded chitosan (CTS-Fe) composite	144:185	Fe(III)-loaded chitosan (CTS-Fe) composite	144:185	Fe(III)-loaded chitosan (CTS-Fe) composite was used for the first time to remove and recover phosphorus (P) from waste activated sludge (WAS) via anaerobic digestion (AD).
32980603	3	61	theme	sludge	554:559	arg1	phase					545:549	the solid phase	535:549	the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS)	535:603	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	4	62	theme	-P	771:772	arg1	compounds					774:782	Fe(III)-P compounds	764:782	Fe(III)-P compounds	764:782	This is probably brought about by the added CTS-Fe enhanced the reduction of Fe(III)-P compounds in the sludge with phosphate released into the liquid phase.
32980603	8	63	theme	methane	1260:1266	arg1	production					1268:1277	methane production	1260:1277	methane production	1260:1277	Furthermore, the addition of CTS-Fe increased methane production by 11.9 - 32.2% under the tested conditions, likely attributable to the enhanced hydrolysis of WAS under CTS-Fe supplementation.
32980603	2	64	from	pathway	337:343	arg1	process					389:395	the AD process	382:395	the AD process	382:395	The P transformation pathway and the effect of CTS-Fe addition on the AD process were investigated using batch experiments.
32980603	9	65	theme	new	1564:1566	arg1	approach					1568:1575	a new approach	1562:1575	a new approach for simultaneous P removal/recovery and enhanced methane production from AD of WAS	1562:1658	As the P-loaded CTS-Fe particles can be easily separated and recovered from the AD system and further reutilized in agriculture, this study could provide a new approach for simultaneous P removal/recovery and enhanced methane production from AD of WAS.
32980603	1	66	dep	recover	229:235	arg1	WAS					281:283	WAS	281:283	WAS	281:283	Fe(III)-loaded chitosan (CTS-Fe) composite was used for the first time to remove and recover phosphorus (P) from waste activated sludge (WAS) via anaerobic digestion (AD).
32980603	6	67	theme	vivianite	1010:1018	arg1	crystals					1020:1027	vivianite crystals	1010:1027	vivianite crystals	1010:1027	Notably, partial Fe(III) on the CTS-Fe was reduced and effectively combined with P to form vivianite crystals on the CTS-Fe surface during the AD process.
32980603	2	68	from	effect	353:358	arg1	process					389:395	the AD process	382:395	the AD process	382:395	The P transformation pathway and the effect of CTS-Fe addition on the AD process were investigated using batch experiments.
32980603	7	69	theme	Characterization	1074:1089	arg1	analysis					1091:1098	Characterization analysis	1074:1098	Characterization analysis	1074:1098	Characterization analysis demonstrated that ligand exchange and chemical precipitation were the dominant mechanisms for P removal/recovery.
32980603	9	70	theme	AD	1488:1489	arg1	system					1491:1496	the AD system	1484:1496	the AD system	1484:1496	As the P-loaded CTS-Fe particles can be easily separated and recovered from the AD system and further reutilized in agriculture, this study could provide a new approach for simultaneous P removal/recovery and enhanced methane production from AD of WAS.
32980603	4	71	theme	liquid	831:836	arg1	phase					838:842	the liquid phase	827:842	the liquid phase	827:842	This is probably brought about by the added CTS-Fe enhanced the reduction of Fe(III)-P compounds in the sludge with phosphate released into the liquid phase.
32980603	7	72	theme	ligand	1118:1123	arg1	exchange					1125:1132	ligand exchange	1118:1132	ligand exchange	1118:1132	Characterization analysis demonstrated that ligand exchange and chemical precipitation were the dominant mechanisms for P removal/recovery.
32980603	7	72	theme	ligand	1118:1123	arg1	precipitation					1147:1159	chemical precipitation	1138:1159	chemical precipitation	1138:1159	Characterization analysis demonstrated that ligand exchange and chemical precipitation were the dominant mechanisms for P removal/recovery.
32980603	7	72	theme	ligand	1118:1123	arg1	mechanisms					1179:1188	the dominant mechanisms	1166:1188	the dominant mechanisms for P removal/recovery	1166:1211	Characterization analysis demonstrated that ligand exchange and chemical precipitation were the dominant mechanisms for P removal/recovery.
32980603	7	73	theme	dominant	1170:1177	arg1	exchange					1125:1132	ligand exchange	1118:1132	ligand exchange	1118:1132	Characterization analysis demonstrated that ligand exchange and chemical precipitation were the dominant mechanisms for P removal/recovery.
32980603	7	73	theme	dominant	1170:1177	arg1	precipitation					1147:1159	chemical precipitation	1138:1159	chemical precipitation	1138:1159	Characterization analysis demonstrated that ligand exchange and chemical precipitation were the dominant mechanisms for P removal/recovery.
32980603	7	73	theme	dominant	1170:1177	arg1	mechanisms					1179:1188	the dominant mechanisms	1166:1188	the dominant mechanisms for P removal/recovery	1166:1211	Characterization analysis demonstrated that ligand exchange and chemical precipitation were the dominant mechanisms for P removal/recovery.
32980603	3	74	from	reduction	522:530	arg1	phase					545:549	the solid phase	535:549	the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS)	535:603	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	3	75	dep	control	643:649	arg1	mg/g-SS					657:663	2.77 mg/g-SS	652:663	2.77 mg/g-SS	652:663	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	3	75	dep	control	643:649	arg1	addition					676:683	no CTS-Fe addition	666:683	no CTS-Fe addition	666:683	The P fractionation results indicate that non-apatite inorganic phosphorus (NAIP) reduction in the solid phase of sludge at 20 g/L of CTS-Fe addition (6.72 mg/g-SS) was 2.4 times higher than that in the control (2.77 mg/g-SS, no CTS-Fe addition).
32980603	2	76	theme	addition	370:377	arg1	pathway					337:343	The P transformation pathway	316:343	The P transformation pathway	316:343	The P transformation pathway and the effect of CTS-Fe addition on the AD process were investigated using batch experiments.
32980603	2	76	theme	addition	370:377	arg1	effect					353:358	the effect	349:358	the effect of CTS-Fe addition on the AD process	349:395	The P transformation pathway and the effect of CTS-Fe addition on the AD process were investigated using batch experiments.
32980603	1	77	theme	-loaded	151:157	arg1	composite					177:185	Fe(III)-loaded chitosan (CTS-Fe) composite	144:185	Fe(III)-loaded chitosan (CTS-Fe) composite	144:185	Fe(III)-loaded chitosan (CTS-Fe) composite was used for the first time to remove and recover phosphorus (P) from waste activated sludge (WAS) via anaerobic digestion (AD).
33321677	10	0	theme	cell	1820:1823	arg1	morphology					1825:1834	cell morphology	1820:1834	cell morphology	1820:1834	Cell viability was evaluated by MTT assay as well as double staining and visualized under fluorescence microscopy, while cell morphology was analyzed through scanning electron microscopy.
33321677	2	1	theme	hydrogels	392:400	arg1	synthesis					357:365	the synthesis	353:365	the synthesis of hybrid hydroxyapatite hydrogels, which were subsequently printed to form 3D scaffolds for bone tissue engineering applications	353:495	In this work, a bioinspired approach is adopted for the synthesis of hybrid hydroxyapatite hydrogels, which were subsequently printed to form 3D scaffolds for bone tissue engineering applications.
33321677	1	2	theme	tissue	293:298	arg1	regeneration					269:280	the guided regeneration	258:280	the guided regeneration of natural tissue	258:298	Additive manufacturing holds promise for the fabrication of three-dimensional scaffolds with precise geometry, to serve as substrates for the guided regeneration of natural tissue.
33321677	8	3	theme	characterization	1397:1412	arg1	techniques					1414:1423	both characterization techniques	1392:1423	both characterization techniques	1392:1423	Results of both characterization techniques, showed that the scaffolds' porosity as well as their modulus values, fall within the corresponding range of the respective values of cancellous bone.
33321677	2	4	theme	hydroxyapatite	377:390	arg1	hydrogels					392:400	hybrid hydroxyapatite hydrogels	370:400	hybrid hydroxyapatite hydrogels	370:400	In this work, a bioinspired approach is adopted for the synthesis of hybrid hydroxyapatite hydrogels, which were subsequently printed to form 3D scaffolds for bone tissue engineering applications.
33321677	2	5	theme	bioinspired	317:327	arg1	approach					329:336	a bioinspired approach	315:336	a bioinspired approach	315:336	In this work, a bioinspired approach is adopted for the synthesis of hybrid hydroxyapatite hydrogels, which were subsequently printed to form 3D scaffolds for bone tissue engineering applications.
33321677	3	6	theme	l-arginine	618:627	arg1	presence					588:595	the presence	584:595	the presence of both chitosan and l-arginine	584:627	These hydrogels consist of hydroxyapatite nanocrystals, biomimetically synthesized in the presence of both chitosan and l-arginine.
33321677	7	7	theme	porosity	1257:1264	arg1	Evaluation					1243:1252	Evaluation	1243:1252	Evaluation of porosity	1243:1264	Evaluation of porosity was performed using micro-computed tomography and nanomechanical properties were assessed through nanoindentation.
33321677	5	8	dep	parameters	873:882	arg1	parameters					873:882	several parameters	865:882	several parameters (flow, infill and perimeter speed)	865:917	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	5	8	dep	parameters	873:882	arg1	infill					891:896	infill	891:896	infill	891:896	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	5	8	dep	parameters	873:882	arg1	speed					912:916	perimeter speed	902:916	perimeter speed	902:916	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	5	8	dep	parameters	873:882	arg1	flow					885:888	flow	885:888	flow	885:888	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	3	9	theme	chitosan	605:612	arg1	presence					588:595	the presence	584:595	the presence of both chitosan and l-arginine	584:627	These hydrogels consist of hydroxyapatite nanocrystals, biomimetically synthesized in the presence of both chitosan and l-arginine.
33321677	4	10	theme	mechanical	647:656	arg1	properties					658:667	their mechanical properties	641:667	their mechanical properties	641:667	To improve their mechanical properties, chemical crosslinking was performed using a natural crosslinking agent (genipin), and their rheology was modified by employing an acetic acid/gelatin solution.
33321677	10	11	theme	fluorescence	1789:1800	arg1	microscopy					1802:1811	fluorescence microscopy	1789:1811	fluorescence microscopy	1789:1811	Cell viability was evaluated by MTT assay as well as double staining and visualized under fluorescence microscopy, while cell morphology was analyzed through scanning electron microscopy.
33321677	1	12	with	fabrication	165:175	arg1	geometry					221:228	precise geometry	213:228	precise geometry	213:228	Additive manufacturing holds promise for the fabrication of three-dimensional scaffolds with precise geometry, to serve as substrates for the guided regeneration of natural tissue.
33321677	10	13	theme	double	1752:1757	arg1	staining					1759:1766	double staining	1752:1766	MTT assay as well as double staining	1731:1766	Cell viability was evaluated by MTT assay as well as double staining and visualized under fluorescence microscopy, while cell morphology was analyzed through scanning electron microscopy.
33321677	6	14	theme	porous	1212:1217	arg1	network					1234:1240	a porous interconnected network	1210:1240	a porous interconnected network	1210:1240	Following the printing procedure, the 3D scaffolds were freeze dried in order to remove the entrapped solvents and therefore, obtain a porous interconnected network.
33321677	8	15	theme	cancellous	1559:1568	arg1	bone					1570:1573	cancellous bone	1559:1573	cancellous bone	1559:1573	Results of both characterization techniques, showed that the scaffolds' porosity as well as their modulus values, fall within the corresponding range of the respective values of cancellous bone.
33321677	5	16	theme	3D	844:845	arg1	process					856:862	the 3D printing process	840:862	the 3D printing process	840:862	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	0	17	theme	Additive	0:7	arg1	manufacturing					9:21	Additive manufacturing	0:21	Additive manufacturing of hydroxyapatite-chitosan-genipin composite scaffolds for bone tissue engineering applications.	0:118	Additive manufacturing of hydroxyapatite-chitosan-genipin composite scaffolds for bone tissue engineering applications.
33321677	4	18	theme	crosslinking	722:733	arg1	agent					735:739	a natural crosslinking agent	712:739	a natural crosslinking agent (genipin)	712:749	To improve their mechanical properties, chemical crosslinking was performed using a natural crosslinking agent (genipin), and their rheology was modified by employing an acetic acid/gelatin solution.
33321677	4	18	theme	crosslinking	722:733	arg1	genipin					742:748	genipin	742:748	genipin	742:748	To improve their mechanical properties, chemical crosslinking was performed using a natural crosslinking agent (genipin), and their rheology was modified by employing an acetic acid/gelatin solution.
33321677	5	19	theme	several	865:871	arg1	parameters					873:882	several parameters	865:882	several parameters (flow, infill and perimeter speed)	865:917	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	5	19	theme	several	865:871	arg1	infill					891:896	infill	891:896	infill	891:896	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	5	19	theme	several	865:871	arg1	speed					912:916	perimeter speed	902:916	perimeter speed	902:916	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	5	19	theme	several	865:871	arg1	flow					885:888	flow	885:888	flow	885:888	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	11	20	theme	cell-friendly	1952:1964	arg1	environment					1966:1976	a cell-friendly environment	1950:1976	a cell-friendly environment	1950:1976	Biocompatibility tests, revealed that the scaffolds constitute a cell-friendly environment, allowed them to adhere on the scaffolds' surface, increase their population and maintain high levels of viability.
33321677	9	21	theme	printed	1607:1613	arg1	scaffolds					1615:1623	the 3D printed scaffolds	1600:1623	the 3D printed scaffolds	1600:1623	The biocompatibility of the 3D printed scaffolds was assessed using MG63 human osteosarcoma cells for 7 days of culturing.
33321677	9	22	theme	MG63	1644:1647	arg1	cells					1668:1672	MG63 human osteosarcoma cells	1644:1672	MG63 human osteosarcoma cells	1644:1672	The biocompatibility of the 3D printed scaffolds was assessed using MG63 human osteosarcoma cells for 7 days of culturing.
33321677	1	23	theme	Additive	120:127	arg1	manufacturing					129:141	Additive manufacturing	120:141	Additive manufacturing	120:141	Additive manufacturing holds promise for the fabrication of three-dimensional scaffolds with precise geometry, to serve as substrates for the guided regeneration of natural tissue.
33321677	1	23	theme	Additive	120:127	arg1	substrates					243:252	substrates	243:252	substrates for the guided regeneration of natural tissue	243:298	Additive manufacturing holds promise for the fabrication of three-dimensional scaffolds with precise geometry, to serve as substrates for the guided regeneration of natural tissue.
33321677	10	24	theme	MTT	1731:1733	arg1	assay					1735:1739	MTT assay	1731:1739	MTT assay as well as double staining	1731:1766	Cell viability was evaluated by MTT assay as well as double staining and visualized under fluorescence microscopy, while cell morphology was analyzed through scanning electron microscopy.
33321677	2	25	theme	engineering	472:482	arg1	applications					484:495	bone tissue engineering applications	460:495	bone tissue engineering applications	460:495	In this work, a bioinspired approach is adopted for the synthesis of hybrid hydroxyapatite hydrogels, which were subsequently printed to form 3D scaffolds for bone tissue engineering applications.
33321677	5	26	with	scaffolds	963:971	arg1	micro-architecture					1003:1020	micro-architecture	1003:1020	micro-architecture	1003:1020	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	5	26	with	scaffolds	963:971	arg1	geometry					990:997	predesigned geometry	978:997	predesigned geometry	978:997	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	9	27	theme	osteosarcoma	1655:1666	arg1	cells					1668:1672	MG63 human osteosarcoma cells	1644:1672	MG63 human osteosarcoma cells	1644:1672	The biocompatibility of the 3D printed scaffolds was assessed using MG63 human osteosarcoma cells for 7 days of culturing.
33321677	6	28	theme	3D	1115:1116	arg1	scaffolds					1118:1126	the 3D scaffolds	1111:1126	the 3D scaffolds	1111:1126	Following the printing procedure, the 3D scaffolds were freeze dried in order to remove the entrapped solvents and therefore, obtain a porous interconnected network.
33321677	2	29	theme	tissue	465:470	arg1	applications					484:495	bone tissue engineering applications	460:495	bone tissue engineering applications	460:495	In this work, a bioinspired approach is adopted for the synthesis of hybrid hydroxyapatite hydrogels, which were subsequently printed to form 3D scaffolds for bone tissue engineering applications.
33321677	5	30	theme	predesigned	978:988	arg1	geometry					990:997	predesigned geometry	978:997	predesigned geometry	978:997	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	4	31	theme	acid/gelatin	807:818	arg1	solution					820:827	an acetic acid/gelatin solution	797:827	an acetic acid/gelatin solution	797:827	To improve their mechanical properties, chemical crosslinking was performed using a natural crosslinking agent (genipin), and their rheology was modified by employing an acetic acid/gelatin solution.
33321677	8	32	theme	modulus	1479:1485	arg1	values					1487:1492	their modulus values	1473:1492	their modulus values	1473:1492	Results of both characterization techniques, showed that the scaffolds' porosity as well as their modulus values, fall within the corresponding range of the respective values of cancellous bone.
33321677	2	33	theme	bone	460:463	arg1	applications					484:495	bone tissue engineering applications	460:495	bone tissue engineering applications	460:495	In this work, a bioinspired approach is adopted for the synthesis of hybrid hydroxyapatite hydrogels, which were subsequently printed to form 3D scaffolds for bone tissue engineering applications.
33321677	11	34	theme	Biocompatibility	1887:1902	arg1	tests					1904:1908	Biocompatibility tests	1887:1908	Biocompatibility tests	1887:1908	Biocompatibility tests, revealed that the scaffolds constitute a cell-friendly environment, allowed them to adhere on the scaffolds' surface, increase their population and maintain high levels of viability.
33321677	4	35	theme	chemical	670:677	arg1	crosslinking					679:690	chemical crosslinking	670:690	chemical crosslinking	670:690	To improve their mechanical properties, chemical crosslinking was performed using a natural crosslinking agent (genipin), and their rheology was modified by employing an acetic acid/gelatin solution.
33321677	1	36	theme	precise	213:219	arg1	geometry					221:228	precise geometry	213:228	precise geometry	213:228	Additive manufacturing holds promise for the fabrication of three-dimensional scaffolds with precise geometry, to serve as substrates for the guided regeneration of natural tissue.
33321677	9	37	theme	scaffolds	1615:1623	arg1	biocompatibility					1580:1595	The biocompatibility	1576:1595	The biocompatibility of the 3D printed scaffolds	1576:1623	The biocompatibility of the 3D printed scaffolds was assessed using MG63 human osteosarcoma cells for 7 days of culturing.
33321677	7	38	theme	nanomechanical	1316:1329	arg1	properties					1331:1340	nanomechanical properties	1316:1340	nanomechanical properties	1316:1340	Evaluation of porosity was performed using micro-computed tomography and nanomechanical properties were assessed through nanoindentation.
33321677	0	39	theme	scaffolds	68:76	arg1	manufacturing					9:21	Additive manufacturing	0:21	Additive manufacturing of hydroxyapatite-chitosan-genipin composite scaffolds for bone tissue engineering applications.	0:118	Additive manufacturing of hydroxyapatite-chitosan-genipin composite scaffolds for bone tissue engineering applications.
33321677	9	40	theme	human	1649:1653	arg1	cells					1668:1672	MG63 human osteosarcoma cells	1644:1672	MG63 human osteosarcoma cells	1644:1672	The biocompatibility of the 3D printed scaffolds was assessed using MG63 human osteosarcoma cells for 7 days of culturing.
33321677	4	41	theme	natural	714:720	arg1	agent					735:739	a natural crosslinking agent	712:739	a natural crosslinking agent (genipin)	712:749	To improve their mechanical properties, chemical crosslinking was performed using a natural crosslinking agent (genipin), and their rheology was modified by employing an acetic acid/gelatin solution.
33321677	4	41	theme	natural	714:720	arg1	genipin					742:748	genipin	742:748	genipin	742:748	To improve their mechanical properties, chemical crosslinking was performed using a natural crosslinking agent (genipin), and their rheology was modified by employing an acetic acid/gelatin solution.
33321677	8	42	theme	techniques	1414:1423	arg1	Results					1381:1387	Results	1381:1387	Results	1381:1387	Results of both characterization techniques, showed that the scaffolds' porosity as well as their modulus values, fall within the corresponding range of the respective values of cancellous bone.
33321677	2	43	theme	3D	443:444	arg1	scaffolds					446:454	3D scaffolds	443:454	3D scaffolds for bone tissue engineering applications	443:495	In this work, a bioinspired approach is adopted for the synthesis of hybrid hydroxyapatite hydrogels, which were subsequently printed to form 3D scaffolds for bone tissue engineering applications.
33321677	0	44	theme	composite	58:66	arg1	scaffolds					68:76	hydroxyapatite-chitosan-genipin composite scaffolds	26:76	hydroxyapatite-chitosan-genipin composite scaffolds	26:76	Additive manufacturing of hydroxyapatite-chitosan-genipin composite scaffolds for bone tissue engineering applications.
33321677	5	45	theme	printing	847:854	arg1	process					856:862	the 3D printing process	840:862	the 3D printing process	840:862	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	8	46	theme	respective	1538:1547	arg1	values					1549:1554	the respective values	1534:1554	the respective values of cancellous bone	1534:1573	Results of both characterization techniques, showed that the scaffolds' porosity as well as their modulus values, fall within the corresponding range of the respective values of cancellous bone.
33321677	0	47	theme	hydroxyapatite-chitosan-genipin	26:56	arg1	scaffolds					68:76	hydroxyapatite-chitosan-genipin composite scaffolds	26:76	hydroxyapatite-chitosan-genipin composite scaffolds	26:76	Additive manufacturing of hydroxyapatite-chitosan-genipin composite scaffolds for bone tissue engineering applications.
33321677	5	48	theme	perimeter	902:910	arg1	parameters					873:882	several parameters	865:882	several parameters (flow, infill and perimeter speed)	865:917	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	5	48	theme	perimeter	902:910	arg1	speed					912:916	perimeter speed	902:916	perimeter speed	902:916	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	0	49	theme	bone	82:85	arg1	applications					106:117	bone tissue engineering applications	82:117	bone tissue engineering applications	82:117	Additive manufacturing of hydroxyapatite-chitosan-genipin composite scaffolds for bone tissue engineering applications.
33321677	11	50	theme	viability	2083:2091	arg1	levels					2073:2078	high levels	2068:2078	high levels of viability	2068:2091	Biocompatibility tests, revealed that the scaffolds constitute a cell-friendly environment, allowed them to adhere on the scaffolds' surface, increase their population and maintain high levels of viability.
33321677	7	51	theme	micro-computed	1286:1299	arg1	tomography					1301:1310	micro-computed tomography	1286:1310	micro-computed tomography	1286:1310	Evaluation of porosity was performed using micro-computed tomography and nanomechanical properties were assessed through nanoindentation.
33321677	9	52	theme	culturing	1688:1696	arg1	7 days					1678:1683	7 days	1678:1683	7 days of culturing	1678:1696	The biocompatibility of the 3D printed scaffolds was assessed using MG63 human osteosarcoma cells for 7 days of culturing.
33321677	2	53	theme	hybrid	370:375	arg1	hydrogels					392:400	hybrid hydroxyapatite hydrogels	370:400	hybrid hydroxyapatite hydrogels	370:400	In this work, a bioinspired approach is adopted for the synthesis of hybrid hydroxyapatite hydrogels, which were subsequently printed to form 3D scaffolds for bone tissue engineering applications.
33321677	10	54	theme	Cell	1699:1702	arg1	viability					1704:1712	Cell viability	1699:1712	Cell viability	1699:1712	Cell viability was evaluated by MTT assay as well as double staining and visualized under fluorescence microscopy, while cell morphology was analyzed through scanning electron microscopy.
33321677	6	55	theme	interconnected	1219:1232	arg1	network					1234:1240	a porous interconnected network	1210:1240	a porous interconnected network	1210:1240	Following the printing procedure, the 3D scaffolds were freeze dried in order to remove the entrapped solvents and therefore, obtain a porous interconnected network.
33321677	6	56	theme	entrapped	1169:1177	arg1	solvents					1179:1186	the entrapped solvents	1165:1186	the entrapped solvents	1165:1186	Following the printing procedure, the 3D scaffolds were freeze dried in order to remove the entrapped solvents and therefore, obtain a porous interconnected network.
33321677	10	57	theme	scanning	1857:1864	arg1	microscopy					1875:1884	scanning electron microscopy	1857:1884	scanning electron microscopy	1857:1884	Cell viability was evaluated by MTT assay as well as double staining and visualized under fluorescence microscopy, while cell morphology was analyzed through scanning electron microscopy.
33321677	8	58	theme	values	1549:1554	arg1	range					1525:1529	the corresponding range	1507:1529	the corresponding range of the respective values of cancellous bone	1507:1573	Results of both characterization techniques, showed that the scaffolds' porosity as well as their modulus values, fall within the corresponding range of the respective values of cancellous bone.
33321677	5	59	theme	printing	1047:1054	arg1	15 °C					1069:1073	15 °C	1069:1073	15 °C	1069:1073	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	5	59	theme	printing	1047:1054	arg1	temperature					1056:1066	low printing temperature	1043:1066	low printing temperature (15 °C)	1043:1074	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	11	60	theme	high	2068:2071	arg1	levels					2073:2078	high levels	2068:2078	high levels of viability	2068:2091	Biocompatibility tests, revealed that the scaffolds constitute a cell-friendly environment, allowed them to adhere on the scaffolds' surface, increase their population and maintain high levels of viability.
33321677	6	61	dep	freeze	1133:1138	arg1	dried					1140:1144	dried	1140:1144	were freeze dried in order to remove the entrapped solvents and therefore, obtain a porous interconnected network	1128:1240	Following the printing procedure, the 3D scaffolds were freeze dried in order to remove the entrapped solvents and therefore, obtain a porous interconnected network.
33321677	1	62	theme	guided	262:267	arg1	regeneration					269:280	the guided regeneration	258:280	the guided regeneration of natural tissue	258:298	Additive manufacturing holds promise for the fabrication of three-dimensional scaffolds with precise geometry, to serve as substrates for the guided regeneration of natural tissue.
33321677	5	63	theme	low	1043:1045	arg1	15 °C					1069:1073	15 °C	1069:1073	15 °C	1069:1073	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	5	63	theme	low	1043:1045	arg1	temperature					1056:1066	low printing temperature	1043:1066	low printing temperature (15 °C)	1043:1074	Regarding the 3D printing process, several parameters (flow, infill and perimeter speed) were studied in order to accurately produce scaffolds with predesigned geometry and micro-architecture, while also applying low printing temperature (15 °C).
33321677	8	64	theme	bone	1570:1573	arg1	values					1549:1554	the respective values	1534:1554	the respective values of cancellous bone	1534:1573	Results of both characterization techniques, showed that the scaffolds' porosity as well as their modulus values, fall within the corresponding range of the respective values of cancellous bone.
33321677	6	65	dep	remove	1158:1163	arg1	obtain					1203:1208	obtain	1203:1208	obtain a porous interconnected network	1203:1240	Following the printing procedure, the 3D scaffolds were freeze dried in order to remove the entrapped solvents and therefore, obtain a porous interconnected network.
33321677	4	66	theme	acetic	800:805	arg1	solution					820:827	an acetic acid/gelatin solution	797:827	an acetic acid/gelatin solution	797:827	To improve their mechanical properties, chemical crosslinking was performed using a natural crosslinking agent (genipin), and their rheology was modified by employing an acetic acid/gelatin solution.
33321677	3	67	theme	hydroxyapatite	525:538	arg1	nanocrystals					540:551	hydroxyapatite nanocrystals	525:551	hydroxyapatite nanocrystals	525:551	These hydrogels consist of hydroxyapatite nanocrystals, biomimetically synthesized in the presence of both chitosan and l-arginine.
33321677	10	68	theme	electron	1866:1873	arg1	microscopy					1875:1884	scanning electron microscopy	1857:1884	scanning electron microscopy	1857:1884	Cell viability was evaluated by MTT assay as well as double staining and visualized under fluorescence microscopy, while cell morphology was analyzed through scanning electron microscopy.
33321677	0	69	theme	engineering	94:104	arg1	applications					106:117	bone tissue engineering applications	82:117	bone tissue engineering applications	82:117	Additive manufacturing of hydroxyapatite-chitosan-genipin composite scaffolds for bone tissue engineering applications.
33321677	6	70	theme	printing	1091:1098	arg1	procedure					1100:1108	the printing procedure	1087:1108	the printing procedure	1087:1108	Following the printing procedure, the 3D scaffolds were freeze dried in order to remove the entrapped solvents and therefore, obtain a porous interconnected network.
33321677	8	71	theme	corresponding	1511:1523	arg1	range					1525:1529	the corresponding range	1507:1529	the corresponding range of the respective values of cancellous bone	1507:1573	Results of both characterization techniques, showed that the scaffolds' porosity as well as their modulus values, fall within the corresponding range of the respective values of cancellous bone.
33321677	1	72	theme	three-dimensional	180:196	arg1	scaffolds					198:206	three-dimensional scaffolds	180:206	three-dimensional scaffolds	180:206	Additive manufacturing holds promise for the fabrication of three-dimensional scaffolds with precise geometry, to serve as substrates for the guided regeneration of natural tissue.
33321677	0	73	theme	tissue	87:92	arg1	applications					106:117	bone tissue engineering applications	82:117	bone tissue engineering applications	82:117	Additive manufacturing of hydroxyapatite-chitosan-genipin composite scaffolds for bone tissue engineering applications.
33321677	3	74	dep	consist	514:520	arg1	synthesized					569:579	synthesized	569:579	synthesized in the presence of both chitosan and l-arginine	569:627	These hydrogels consist of hydroxyapatite nanocrystals, biomimetically synthesized in the presence of both chitosan and l-arginine.
33321677	1	75	theme	scaffolds	198:206	arg1	fabrication					165:175	the fabrication	161:175	the fabrication of three-dimensional scaffolds with precise geometry	161:228	Additive manufacturing holds promise for the fabrication of three-dimensional scaffolds with precise geometry, to serve as substrates for the guided regeneration of natural tissue.
33321677	1	76	theme	natural	285:291	arg1	tissue					293:298	natural tissue	285:298	natural tissue	285:298	Additive manufacturing holds promise for the fabrication of three-dimensional scaffolds with precise geometry, to serve as substrates for the guided regeneration of natural tissue.
31940189	0	0	theme	Addition	86:93	arg1	Effect					58:63	Effect	58:63	Multifunctional Bioplastics Inspired by Wood Composition: Effect of Hydrolyzed Lignin Addition to Xylan-Cellulose Matrices.	0:122	Multifunctional Bioplastics Inspired by Wood Composition: Effect of Hydrolyzed Lignin Addition to Xylan-Cellulose Matrices.
31940189	7	1	theme	polymeric	1035:1043	arg1	materials					1045:1053	Such new polymeric materials	1026:1053	Such new polymeric materials	1026:1053	Such new polymeric materials are presented as alternatives to common man-made petroleum-based plastics used for food packaging.
31940189	7	1	theme	polymeric	1035:1043	arg1	alternatives					1072:1083	alternatives	1072:1083	alternatives to common man-made petroleum-based plastics used for food packaging	1072:1151	Such new polymeric materials are presented as alternatives to common man-made petroleum-based plastics used for food packaging.
31940189	1	2	theme	amorphous	174:182	arg1	reassembly					184:193	amorphous reassembly	174:193	amorphous reassembly of cellulose, hemicelluloses (xylan), and hydrolyzed lignin	174:253	Multifunctional bioplastics have been prepared by amorphous reassembly of cellulose, hemicelluloses (xylan), and hydrolyzed lignin.
31940189	0	3	theme	Lignin	79:84	arg1	Addition					86:93	Hydrolyzed Lignin Addition	68:93	Hydrolyzed Lignin Addition	68:93	Multifunctional Bioplastics Inspired by Wood Composition: Effect of Hydrolyzed Lignin Addition to Xylan-Cellulose Matrices.
31940189	2	4	theme	different	372:380	arg1	percentages					382:392	different percentages	372:392	different percentages	372:392	For this, the biopolymers were dissolved in a trifluoroacetic acid-trifluoroacetic anhydride mixture and blended in different percentages, simulating those found in natural woods.
31940189	0	5	theme	Xylan-Cellulose	98:112	arg1	Matrices					114:121	Xylan-Cellulose Matrices	98:121	Xylan-Cellulose Matrices	98:121	Multifunctional Bioplastics Inspired by Wood Composition: Effect of Hydrolyzed Lignin Addition to Xylan-Cellulose Matrices.
31940189	5	6	theme	oxygen	702:707	arg1	hydrodynamics					687:699	hydrodynamics	687:699	hydrodynamics	687:699	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	5	6	theme	oxygen	702:707	arg1	barrier					709:715	oxygen barrier	702:715	oxygen barrier	702:715	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	7	7	theme	Such	1026:1029	arg1	materials					1045:1053	Such new polymeric materials	1026:1053	Such new polymeric materials	1026:1053	Such new polymeric materials are presented as alternatives to common man-made petroleum-based plastics used for food packaging.
31940189	7	7	theme	Such	1026:1029	arg1	alternatives					1072:1083	alternatives	1072:1083	alternatives to common man-made petroleum-based plastics used for food packaging	1072:1151	Such new polymeric materials are presented as alternatives to common man-made petroleum-based plastics used for food packaging.
31940189	5	8	theme	higher	638:643	arg1	proportions					645:655	higher proportions	638:655	higher proportions of hydrolyzed lignin	638:676	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	3	9	theme	solvents	521:528	arg1	evaporation					502:512	the complete evaporation	489:512	the complete evaporation of the solvents	489:528	Free-standing and flexible films were obtained after the complete evaporation of the solvents.
31940189	5	10	theme	synthetic	874:882	arg1	polymers					898:905	synthetic and bio-based polymers	874:905	synthetic and bio-based polymers commonly used for packaging applications	874:946	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	2	11	theme	natural	421:427	arg1	woods					429:433	natural woods	421:433	natural woods	421:433	For this, the biopolymers were dissolved in a trifluoroacetic acid-trifluoroacetic anhydride mixture and blended in different percentages, simulating those found in natural woods.
31940189	5	12	theme	hydrolyzed	660:669	arg1	lignin					671:676	hydrolyzed lignin	660:676	hydrolyzed lignin	660:676	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	1	13	theme	cellulose	198:206	arg1	reassembly					184:193	amorphous reassembly	174:193	amorphous reassembly of cellulose, hemicelluloses (xylan), and hydrolyzed lignin	174:253	Multifunctional bioplastics have been prepared by amorphous reassembly of cellulose, hemicelluloses (xylan), and hydrolyzed lignin.
31940189	0	14	theme	Bioplastics	16:26	arg1	Inspired					28:35	Multifunctional Bioplastics Inspired	0:35	Multifunctional Bioplastics Inspired by Wood Composition: Effect of Hydrolyzed Lignin Addition to Xylan-Cellulose Matrices.	0:122	Multifunctional Bioplastics Inspired by Wood Composition: Effect of Hydrolyzed Lignin Addition to Xylan-Cellulose Matrices.
31940189	5	15	theme	lignin	671:676	arg1	proportions					645:655	higher proportions	638:655	higher proportions of hydrolyzed lignin	638:676	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	5	16	theme	higher	790:795	arg1	related					815:821	related	815:821	related	815:821	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	5	16	theme	higher	790:795	arg1	content					803:809	a higher xylan content	788:809	a higher xylan content	788:809	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	2	17	theme	anhydride	339:347	arg1	mixture					349:355	a trifluoroacetic acid-trifluoroacetic anhydride mixture	300:355	a trifluoroacetic acid-trifluoroacetic anhydride mixture	300:355	For this, the biopolymers were dissolved in a trifluoroacetic acid-trifluoroacetic anhydride mixture and blended in different percentages, simulating those found in natural woods.
31940189	3	18	theme	flexible	454:461	arg1	films					463:467	Free-standing and flexible films	436:467	Free-standing and flexible films	436:467	Free-standing and flexible films were obtained after the complete evaporation of the solvents.
31940189	0	19	theme	Multifunctional	0:14	arg1	Inspired					28:35	Multifunctional Bioplastics Inspired	0:35	Multifunctional Bioplastics Inspired by Wood Composition: Effect of Hydrolyzed Lignin Addition to Xylan-Cellulose Matrices.	0:122	Multifunctional Bioplastics Inspired by Wood Composition: Effect of Hydrolyzed Lignin Addition to Xylan-Cellulose Matrices.
31940189	4	20	theme	physical	584:591	arg1	properties					593:602	the physical properties	580:602	the physical properties	580:602	By varying xylan and hydrolyzed lignin contents, the physical properties were easily tuned.
31940189	2	21	theme	acid-trifluoroacetic	318:337	arg1	mixture					349:355	a trifluoroacetic acid-trifluoroacetic anhydride mixture	300:355	a trifluoroacetic acid-trifluoroacetic anhydride mixture	300:355	For this, the biopolymers were dissolved in a trifluoroacetic acid-trifluoroacetic anhydride mixture and blended in different percentages, simulating those found in natural woods.
31940189	1	22	theme	hemicelluloses	209:222	arg1	xylan					225:229	hemicelluloses (xylan)	209:230	hemicelluloses (xylan)	209:230	Multifunctional bioplastics have been prepared by amorphous reassembly of cellulose, hemicelluloses (xylan), and hydrolyzed lignin.
31940189	7	23	theme	food	1138:1141	arg1	packaging					1143:1151	food packaging	1138:1151	food packaging	1138:1151	Such new polymeric materials are presented as alternatives to common man-made petroleum-based plastics used for food packaging.
31940189	2	24	theme	trifluoroacetic	302:316	arg1	mixture					349:355	a trifluoroacetic acid-trifluoroacetic anhydride mixture	300:355	a trifluoroacetic acid-trifluoroacetic anhydride mixture	300:355	For this, the biopolymers were dissolved in a trifluoroacetic acid-trifluoroacetic anhydride mixture and blended in different percentages, simulating those found in natural woods.
31940189	3	25	theme	complete	493:500	arg1	evaporation					502:512	the complete evaporation	489:512	the complete evaporation of the solvents	489:528	Free-standing and flexible films were obtained after the complete evaporation of the solvents.
31940189	5	26	theme	comparable	860:869	arg1	behavior					850:857	more ductile mechanical behavior	826:857	more ductile mechanical behavior	826:857	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	1	27	theme	xylan	225:229	arg1	reassembly					184:193	amorphous reassembly	174:193	amorphous reassembly of cellulose, hemicelluloses (xylan), and hydrolyzed lignin	174:253	Multifunctional bioplastics have been prepared by amorphous reassembly of cellulose, hemicelluloses (xylan), and hydrolyzed lignin.
31940189	3	28	theme	Free-standing	436:448	arg1	films					463:467	Free-standing and flexible films	436:467	Free-standing and flexible films	436:467	Free-standing and flexible films were obtained after the complete evaporation of the solvents.
31940189	0	29	theme	Wood	40:43	arg1	Composition					45:55	Wood Composition	40:55	Wood Composition	40:55	Multifunctional Bioplastics Inspired by Wood Composition: Effect of Hydrolyzed Lignin Addition to Xylan-Cellulose Matrices.
31940189	4	30	theme	lignin	563:568	arg1	contents					570:577	hydrolyzed lignin contents	552:577	hydrolyzed lignin contents	552:577	By varying xylan and hydrolyzed lignin contents, the physical properties were easily tuned.
31940189	5	31	theme	antibacterial	754:766	arg1	properties					768:777	antibacterial properties	754:777	antibacterial properties	754:777	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	5	31	theme	antibacterial	754:766	arg1	hydrodynamics					687:699	hydrodynamics	687:699	hydrodynamics	687:699	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	5	32	theme	bio-based	888:896	arg1	polymers					898:905	synthetic and bio-based polymers	874:905	synthetic and bio-based polymers commonly used for packaging applications	874:946	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	4	33	theme	hydrolyzed	552:561	arg1	contents					570:577	hydrolyzed lignin contents	552:577	hydrolyzed lignin contents	552:577	By varying xylan and hydrolyzed lignin contents, the physical properties were easily tuned.
31940189	7	34	theme	petroleum-based	1104:1118	arg1	plastics					1120:1127	common man-made petroleum-based plastics	1088:1127	common man-made petroleum-based plastics used for food packaging	1088:1151	Such new polymeric materials are presented as alternatives to common man-made petroleum-based plastics used for food packaging.
31940189	7	35	theme	common	1088:1093	arg1	plastics					1120:1127	common man-made petroleum-based plastics	1088:1127	common man-made petroleum-based plastics used for food packaging	1088:1151	Such new polymeric materials are presented as alternatives to common man-made petroleum-based plastics used for food packaging.
31940189	1	36	theme	Multifunctional	124:138	arg1	bioplastics					140:150	Multifunctional bioplastics	124:150	Multifunctional bioplastics	124:150	Multifunctional bioplastics have been prepared by amorphous reassembly of cellulose, hemicelluloses (xylan), and hydrolyzed lignin.
31940189	5	37	theme	ductile	831:837	arg1	behavior					850:857	more ductile mechanical behavior	826:857	more ductile mechanical behavior	826:857	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	6	38	theme	high	987:990	arg1	rates					1007:1011	high biodegradation rates	987:1011	high biodegradation rates in seawater	987:1023	In addition, these bioplastics showed high biodegradation rates in seawater.
31940189	5	39	theme	grease	718:723	arg1	resistance					725:734	grease resistance	718:734	grease resistance	718:734	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	5	39	theme	grease	718:723	arg1	hydrodynamics					687:699	hydrodynamics	687:699	hydrodynamics	687:699	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	6	40	from	rates	1007:1011	arg1	seawater					1016:1023	seawater	1016:1023	seawater	1016:1023	In addition, these bioplastics showed high biodegradation rates in seawater.
31940189	7	41	theme	man-made	1095:1102	arg1	plastics					1120:1127	common man-made petroleum-based plastics	1088:1127	common man-made petroleum-based plastics used for food packaging	1088:1151	Such new polymeric materials are presented as alternatives to common man-made petroleum-based plastics used for food packaging.
31940189	0	42	dep	Inspired	28:35	arg1	Effect					58:63	Effect	58:63	Multifunctional Bioplastics Inspired by Wood Composition: Effect of Hydrolyzed Lignin Addition to Xylan-Cellulose Matrices.	0:122	Multifunctional Bioplastics Inspired by Wood Composition: Effect of Hydrolyzed Lignin Addition to Xylan-Cellulose Matrices.
31940189	1	43	theme	hydrolyzed	237:246	arg1	lignin					248:253	hydrolyzed lignin	237:253	hydrolyzed lignin	237:253	Multifunctional bioplastics have been prepared by amorphous reassembly of cellulose, hemicelluloses (xylan), and hydrolyzed lignin.
31940189	0	44	theme	Hydrolyzed	68:77	arg1	Addition					86:93	Hydrolyzed Lignin Addition	68:93	Hydrolyzed Lignin Addition	68:93	Multifunctional Bioplastics Inspired by Wood Composition: Effect of Hydrolyzed Lignin Addition to Xylan-Cellulose Matrices.
31940189	2	45	located	found	412:416	arg2	those					406:410	those	406:410	those	406:410	For this, the biopolymers were dissolved in a trifluoroacetic acid-trifluoroacetic anhydride mixture and blended in different percentages, simulating those found in natural woods.
31940189	2	45	located	found	412:416	arg1	woods					429:433	natural woods	421:433	natural woods	421:433	For this, the biopolymers were dissolved in a trifluoroacetic acid-trifluoroacetic anhydride mixture and blended in different percentages, simulating those found in natural woods.
31940189	5	46	theme	packaging	925:933	arg1	applications					935:946	packaging applications	925:946	packaging applications	925:946	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	1	47	theme	lignin	248:253	arg1	reassembly					184:193	amorphous reassembly	174:193	amorphous reassembly of cellulose, hemicelluloses (xylan), and hydrolyzed lignin	174:253	Multifunctional bioplastics have been prepared by amorphous reassembly of cellulose, hemicelluloses (xylan), and hydrolyzed lignin.
31940189	5	48	theme	xylan	797:801	arg1	related					815:821	related	815:821	related	815:821	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	5	48	theme	xylan	797:801	arg1	content					803:809	a higher xylan content	788:809	a higher xylan content	788:809	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	7	49	theme	new	1031:1033	arg1	materials					1045:1053	Such new polymeric materials	1026:1053	Such new polymeric materials	1026:1053	Such new polymeric materials are presented as alternatives to common man-made petroleum-based plastics used for food packaging.
31940189	7	49	theme	new	1031:1033	arg1	alternatives					1072:1083	alternatives	1072:1083	alternatives to common man-made petroleum-based plastics used for food packaging	1072:1151	Such new polymeric materials are presented as alternatives to common man-made petroleum-based plastics used for food packaging.
31940189	5	50	theme	mechanical	839:848	arg1	behavior					850:857	more ductile mechanical behavior	826:857	more ductile mechanical behavior	826:857	In particular, higher proportions of hydrolyzed lignin improved hydrodynamics, oxygen barrier, grease resistance, antioxidant, and antibacterial properties, whereas a higher xylan content was related to more ductile mechanical behavior, comparable to synthetic and bio-based polymers commonly used for packaging applications.
31940189	6	51	theme	biodegradation	992:1005	arg1	rates					1007:1011	high biodegradation rates	987:1011	high biodegradation rates in seawater	987:1023	In addition, these bioplastics showed high biodegradation rates in seawater.
32434157	4	0	theme	Fe	644:645	arg1	nanocomposites					667:680	Au and Fe nanoparticle-loaded nanocomposites	637:680	Au and Fe nanoparticle-loaded nanocomposites based on thermoplastic polyurethane (TPU) and alginate	637:735	Laser ablation in macromolecule solutions was employed for synthesizing Au and Fe nanoparticle-loaded nanocomposites based on thermoplastic polyurethane (TPU) and alginate.
32434157	9	1	theme	global	1946:1951	arg1	charge					1961:1966	the global surface charge	1942:1966	the global surface charge	1942:1966	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	7	2	located	found	1148:1152	arg1	system					1173:1178	the Fe-alginate system	1157:1178	the Fe-alginate system	1157:1178	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	7	2	located	found	1148:1152	arg1	system					1229:1234	the Cu/Zn-alginate and Fe-TPU control system	1191:1234	the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load)	1191:1298	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	7	2	located	found	1148:1152	arg2	phenomenon					1132:1141	a phenomenon	1130:1141	a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load)	1130:1298	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	7	2	located	found	1148:1152	arg2	loadings					1120:1127	mass loadings	1115:1127	mass loadings	1115:1127	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	2	3	theme	protein	312:318	arg1	capacity					331:338	protein adsorption capacity	312:338	the release of metal ions as well as protein adsorption capacity	275:338	In this context, the release of metal ions as well as protein adsorption capacity are hypothesized to be two key processes directing nanocomposite-cell interactions.
32434157	9	4	theme	charge	1961:1966	arg1	collagen					1681:1688	collagen I	1681:1690	collagen I	1681:1690	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	4	theme	charge	1961:1966	arg1	albumin					1663:1669	adsorbed bovine serum albumin	1641:1669	adsorbed bovine serum albumin (BSA)	1641:1675	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	4	theme	charge	1961:1966	arg1	amount					1631:1636	The amount	1627:1636	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites	1627:1745	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	4	theme	charge	1961:1966	arg1	independent					1927:1937	independent	1927:1937	independent	1927:1937	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	3	5	with	relations	530:538	arg1	adsorption					553:562	protein adsorption	545:562	protein adsorption	545:562	The objective of this study is to understand the polymer-matrix effects on ion release kinetics and their relations with protein adsorption.
32434157	9	6	theme	released	1870:1877	arg1	ions					1882:1885	released Fe ions	1870:1885	released Fe ions	1870:1885	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	8	7	theme	detailed	1303:1310	arg1	examination					1324:1334	A detailed mechanistic examination	1301:1334	A detailed mechanistic examination of iron the ion release process	1301:1366	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	9	8	theme	composites	1736:1745	arg1	surface					1699:1705	the surface	1695:1705	the surface of both the alginate and TPU composites	1695:1745	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	7	9	theme	Fe-TPU	1214:1219	arg1	system					1229:1234	the Cu/Zn-alginate and Fe-TPU control system	1191:1234	the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load)	1191:1298	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	6	10	theme	pronounced	901:910	arg1	dependence					912:921	a pronounced dependence	899:921	a pronounced dependence upon embedding of Fe and Au nanoparticles in both polymer matrices	899:988	The physicochemical properties revealed a pronounced dependence upon embedding of Fe and Au nanoparticles in both polymer matrices.
32434157	1	11	theme	tissue-engineering	225:242	arg1	applications					244:255	tissue-engineering applications	225:255	tissue-engineering applications	225:255	Nanocomposites have been widely applied in medical device fabrication and tissue-engineering applications.
32434157	7	12	theme	Cu/Zn-alginate	1195:1208	arg1	system					1229:1234	the Cu/Zn-alginate and Fe-TPU control system	1191:1234	the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load)	1191:1298	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	8	13	theme	iron	1339:1342	arg1	examination					1324:1334	A detailed mechanistic examination	1301:1334	A detailed mechanistic examination of iron the ion release process	1301:1366	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	0	14	from	composites	99:108	arg1	release					36:42	Fe ion release	29:42	Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties	29:148	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	0	14	from	composites	99:108	arg1	mechanism					16:24	Matrix-specific mechanism	0:24	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.	0:149	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	11	15	theme	3D	2205:2206	arg1	printing					2208:2215	3D printing	2205:2215	3D printing	2205:2215	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	10	16	theme	Fe	2053:2054	arg1	nanoparticles					2056:2068	Fe nanoparticles	2053:2068	Fe nanoparticles down to 200 ppm	2053:2084	Interestingly, these effects were already highly pronounced at minute loadings with Fe nanoparticles down to 200 ppm.
32434157	5	17	theme	nanoparticles	829:841	arg1	dispersion					799:808	a three-dimensional homogeneous dispersion	767:808	a three-dimensional homogeneous dispersion of laser-generated nanoparticles in the polymer	767:856	Confocal microscopy revealed a three-dimensional homogeneous dispersion of laser-generated nanoparticles in the polymer.
32434157	7	18	theme	nanoparticle	1281:1292	arg1	load					1294:1297	the nanoparticle load	1277:1297	the nanoparticle load	1277:1297	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	8	19	theme	ion	1348:1350	arg1	process					1360:1366	the ion release process	1344:1366	iron the ion release process	1339:1366	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	11	20	theme	alginate	2146:2153	arg1	Fe					2117:2118	the laser-generated Fe or Au nanoparticle-loaded alginate composites	2097:2164	Fe	2117:2118	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	11	20	theme	alginate	2146:2153	arg1	bioink					2194:2199	a suitable bioink	2183:2199	a suitable bioink for 3D printing	2183:2215	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	11	20	theme	alginate	2146:2153	arg1	composites					2155:2164	the laser-generated Fe or Au nanoparticle-loaded alginate composites	2097:2164	composites	2155:2164	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	11	21	theme	Au	2123:2124	arg1	Fe					2117:2118	the laser-generated Fe or Au nanoparticle-loaded alginate composites	2097:2164	Fe	2117:2118	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	11	21	theme	Au	2123:2124	arg1	bioink					2194:2199	a suitable bioink	2183:2199	a suitable bioink for 3D printing	2183:2215	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	11	21	theme	Au	2123:2124	arg1	composites					2155:2164	the laser-generated Fe or Au nanoparticle-loaded alginate composites	2097:2164	composites	2155:2164	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	8	22	theme	redox	1405:1409	arg1	potential					1411:1419	the redox potential	1401:1419	the redox potential of metals and diffusion of metal ions alone	1401:1463	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	22	theme	redox	1405:1409	arg1	it					1382:1383	it	1382:1383	it	1382:1383	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	7	23	dep	system	1229:1234	arg1	proportioonal					1260:1272	proportioonal	1260:1272	proportioonal	1260:1272	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	7	23	dep	system	1229:1234	arg1	effects					1247:1253	the effects	1243:1253	the effects	1243:1253	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	9	24	theme	unloaded	1794:1801	arg1	polymers					1811:1818	the unloaded control polymers	1790:1818	the unloaded control polymers	1790:1818	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	10	25	with	loadings	2039:2046	arg1	nanoparticles					2056:2068	Fe nanoparticles	2053:2068	Fe nanoparticles down to 200 ppm	2053:2084	Interestingly, these effects were already highly pronounced at minute loadings with Fe nanoparticles down to 200 ppm.
32434157	7	26	theme	Fe-alginate	1161:1171	arg1	system					1173:1178	the Fe-alginate system	1157:1178	the Fe-alginate system	1157:1178	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	2	27	theme	ions	296:299	arg1	release					279:285	the release	275:285	the release of metal ions as well as protein adsorption capacity	275:338	In this context, the release of metal ions as well as protein adsorption capacity are hypothesized to be two key processes directing nanocomposite-cell interactions.
32434157	2	27	theme	ions	296:299	arg1	processes					371:379	two key processes	363:379	two key processes directing nanocomposite-cell interactions	363:421	In this context, the release of metal ions as well as protein adsorption capacity are hypothesized to be two key processes directing nanocomposite-cell interactions.
32434157	2	27	theme	ions	296:299	arg1	capacity					331:338	protein adsorption capacity	312:338	the release of metal ions as well as protein adsorption capacity	275:338	In this context, the release of metal ions as well as protein adsorption capacity are hypothesized to be two key processes directing nanocomposite-cell interactions.
32434157	8	28	theme	special	1568:1574	arg1	behaviors					1584:1592	the special release behaviors	1564:1592	the special release behaviors of iron ions from alginate gels	1564:1624	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	10	29	theme	down	2070:2073	arg1	nanoparticles					2056:2068	Fe nanoparticles	2053:2068	Fe nanoparticles down to 200 ppm	2053:2084	Interestingly, these effects were already highly pronounced at minute loadings with Fe nanoparticles down to 200 ppm.
32434157	0	30	theme	3D-printable	65:76	arg1	composites					99:108	laser-generated 3D-printable nanoparticle-polymer composites	49:108	laser-generated 3D-printable nanoparticle-polymer composites	49:108	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	7	31	theme	mass	1115:1118	arg1	loadings					1120:1127	mass loadings	1115:1127	mass loadings	1115:1127	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	7	31	theme	mass	1115:1118	arg1	phenomenon					1132:1141	a phenomenon	1130:1141	a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load)	1130:1298	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	12	32	theme	wound	2352:2356	arg1	healing					2358:2364	wound healing	2352:2364	wound healing	2352:2364	These findings are potentially relevant for ion-sensitive bio-responses in cell differentiation, endothelisation, vascularisation, or wound healing.
32434157	5	33	theme	homogeneous	787:797	arg1	dispersion					799:808	a three-dimensional homogeneous dispersion	767:808	a three-dimensional homogeneous dispersion of laser-generated nanoparticles in the polymer	767:856	Confocal microscopy revealed a three-dimensional homogeneous dispersion of laser-generated nanoparticles in the polymer.
32434157	1	34	theme	medical	194:200	arg1	fabrication					209:219	medical device fabrication	194:219	medical device fabrication	194:219	Nanocomposites have been widely applied in medical device fabrication and tissue-engineering applications.
32434157	8	35	theme	iron	1597:1600	arg1	ions					1602:1605	iron ions	1597:1605	iron ions from alginate gels	1597:1624	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	36	theme	ions	1454:1457	arg1	diffusion					1435:1443	diffusion	1435:1443	diffusion of metal ions alone	1435:1463	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	36	theme	ions	1454:1457	arg1	metals					1424:1429	metals	1424:1429	metals	1424:1429	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	0	37	theme	adsorption	128:137	arg1	properties					139:148	their protein adsorption properties	114:148	their protein adsorption properties	114:148	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	9	38	theme	adsorbed	1641:1648	arg1	BSA					1672:1674	BSA	1672:1674	BSA	1672:1674	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	38	theme	adsorbed	1641:1648	arg1	albumin					1663:1669	adsorbed bovine serum albumin	1641:1669	adsorbed bovine serum albumin (BSA)	1641:1675	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	6	39	from	embedding	928:936	arg1	matrices					981:988	both polymer matrices	968:988	both polymer matrices	968:988	The physicochemical properties revealed a pronounced dependence upon embedding of Fe and Au nanoparticles in both polymer matrices.
32434157	12	40	theme	ion-sensitive	2262:2274	arg1	bio-responses					2276:2288	ion-sensitive bio-responses	2262:2288	ion-sensitive bio-responses in cell differentiation, endothelisation, vascularisation, or wound healing	2262:2364	These findings are potentially relevant for ion-sensitive bio-responses in cell differentiation, endothelisation, vascularisation, or wound healing.
32434157	0	41	theme	Matrix-specific	0:14	arg1	mechanism					16:24	Matrix-specific mechanism	0:24	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.	0:149	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	7	42	theme	alginate	1051:1058	arg1	gels					1060:1063	alginate gels	1051:1063	alginate gels	1051:1063	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	9	43	theme	serum	1657:1661	arg1	BSA					1672:1674	BSA	1672:1674	BSA	1672:1674	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	43	theme	serum	1657:1661	arg1	albumin					1663:1669	adsorbed bovine serum albumin	1641:1669	adsorbed bovine serum albumin (BSA)	1641:1675	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	44	theme	Fe	1879:1880	arg1	ions					1882:1885	released Fe ions	1870:1885	released Fe ions	1870:1885	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	8	45	from	behaviors	1584:1592	arg1	gels					1621:1624	alginate gels	1612:1624	alginate gels	1612:1624	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	46	dep	iron	1339:1342	arg1	process					1360:1366	the ion release process	1344:1366	iron the ion release process	1339:1366	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	47	theme	nano-metal	1493:1502	arg1	oxides					1504:1509	nano-metal oxides	1493:1509	nano-metal oxides	1493:1509	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	3	48	theme	ion	499:501	arg1	kinetics					511:518	ion release kinetics	499:518	ion release kinetics	499:518	The objective of this study is to understand the polymer-matrix effects on ion release kinetics and their relations with protein adsorption.
32434157	8	49	from	gels	1621:1624	arg1	behaviors					1584:1592	the special release behaviors	1564:1592	the special release behaviors of iron ions from alginate gels	1564:1624	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	49	from	gels	1621:1624	arg1	ions					1602:1605	iron ions	1597:1605	iron ions from alginate gels	1597:1624	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	0	50	theme	ion	32:34	arg1	release					36:42	Fe ion release	29:42	Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties	29:148	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	3	51	theme	study	446:450	arg1	objective					428:436	The objective	424:436	The objective of this study	424:450	The objective of this study is to understand the polymer-matrix effects on ion release kinetics and their relations with protein adsorption.
32434157	9	52	dep	alginate	1719:1726	arg1	the					1715:1717	the	1715:1717	the	1715:1717	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	53	theme	TPU	1732:1734	arg1	composites					1736:1745	both the alginate and TPU composites	1710:1745	both the alginate and TPU composites	1710:1745	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	54	theme	composites	1907:1916	arg1	ions					1882:1885	released Fe ions	1870:1885	released Fe ions	1870:1885	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	54	theme	composites	1907:1916	arg1	porosity					1895:1902	the porosity	1891:1902	the porosity of composites	1891:1916	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	6	55	theme	nanoparticles	951:963	arg1	embedding					928:936	embedding	928:936	embedding of Fe and Au nanoparticles in both polymer matrices	928:988	The physicochemical properties revealed a pronounced dependence upon embedding of Fe and Au nanoparticles in both polymer matrices.
32434157	8	56	theme	ions	1533:1536	arg1	oxides					1504:1509	nano-metal oxides	1493:1509	nano-metal oxides	1493:1509	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	56	theme	ions	1533:1536	arg1	affinity					1515:1522	affinity	1515:1522	affinity of metal ions for alginate	1515:1549	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	9	57	theme	porosity	1895:1902	arg1	concentration					1853:1865	the concentration	1849:1865	the concentration of released Fe ions and the porosity of composites	1849:1916	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	4	58	theme	thermoplastic	691:703	arg1	TPU					719:721	TPU	719:721	TPU	719:721	Laser ablation in macromolecule solutions was employed for synthesizing Au and Fe nanoparticle-loaded nanocomposites based on thermoplastic polyurethane (TPU) and alginate.
32434157	4	58	theme	thermoplastic	691:703	arg1	polyurethane					705:716	thermoplastic polyurethane	691:716	thermoplastic polyurethane (TPU)	691:722	Laser ablation in macromolecule solutions was employed for synthesizing Au and Fe nanoparticle-loaded nanocomposites based on thermoplastic polyurethane (TPU) and alginate.
32434157	4	59	from	ablation	571:578	arg1	solutions					597:605	macromolecule solutions	583:605	macromolecule solutions	583:605	Laser ablation in macromolecule solutions was employed for synthesizing Au and Fe nanoparticle-loaded nanocomposites based on thermoplastic polyurethane (TPU) and alginate.
32434157	2	60	theme	nanocomposite-cell	391:408	arg1	interactions					410:421	nanocomposite-cell interactions	391:421	nanocomposite-cell interactions	391:421	In this context, the release of metal ions as well as protein adsorption capacity are hypothesized to be two key processes directing nanocomposite-cell interactions.
32434157	7	61	theme	Fe	1016:1017	arg1	concentration					1023:1035	the total Fe ion concentration	1006:1035	the total Fe ion concentration released from alginate gels under static conditions	1006:1087	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	5	62	theme	Confocal	738:745	arg1	microscopy					747:756	Confocal microscopy	738:756	Confocal microscopy	738:756	Confocal microscopy revealed a three-dimensional homogeneous dispersion of laser-generated nanoparticles in the polymer.
32434157	6	63	theme	Fe	941:942	arg1	nanoparticles					951:963	Fe and Au nanoparticles	941:963	Fe and Au nanoparticles in both polymer matrices	941:988	The physicochemical properties revealed a pronounced dependence upon embedding of Fe and Au nanoparticles in both polymer matrices.
32434157	2	64	theme	adsorption	320:329	arg1	capacity					331:338	protein adsorption capacity	312:338	the release of metal ions as well as protein adsorption capacity	275:338	In this context, the release of metal ions as well as protein adsorption capacity are hypothesized to be two key processes directing nanocomposite-cell interactions.
32434157	5	65	from	dispersion	799:808	arg1	polymer					850:856	the polymer	846:856	the polymer	846:856	Confocal microscopy revealed a three-dimensional homogeneous dispersion of laser-generated nanoparticles in the polymer.
32434157	9	66	theme	alginate	1719:1726	arg1	composites					1736:1745	both the alginate and TPU composites	1710:1745	both the alginate and TPU composites	1710:1745	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	67	theme	surface	1953:1959	arg1	charge					1961:1966	the global surface charge	1942:1966	the global surface charge	1942:1966	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	4	68	theme	nanoparticle-loaded	647:665	arg1	nanocomposites					667:680	Au and Fe nanoparticle-loaded nanocomposites	637:680	Au and Fe nanoparticle-loaded nanocomposites based on thermoplastic polyurethane (TPU) and alginate	637:735	Laser ablation in macromolecule solutions was employed for synthesizing Au and Fe nanoparticle-loaded nanocomposites based on thermoplastic polyurethane (TPU) and alginate.
32434157	7	69	theme	control	1221:1227	arg1	system					1229:1234	the Cu/Zn-alginate and Fe-TPU control system	1191:1234	the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load)	1191:1298	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	1	70	theme	device	202:207	arg1	fabrication					209:219	medical device fabrication	194:219	medical device fabrication	194:219	Nanocomposites have been widely applied in medical device fabrication and tissue-engineering applications.
32434157	7	71	attach	released	1037:1044	arg2	concentration					1023:1035	the total Fe ion concentration	1006:1035	the total Fe ion concentration released from alginate gels under static conditions	1006:1087	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	7	71	attach	released	1037:1044	arg1	gels					1060:1063	alginate gels	1051:1063	alginate gels	1051:1063	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	8	72	theme	release	1352:1358	arg1	process					1360:1366	the ion release process	1344:1366	iron the ion release process	1339:1366	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	6	73	from	matrices	981:988	arg1	embedding					928:936	embedding	928:936	embedding of Fe and Au nanoparticles in both polymer matrices	928:988	The physicochemical properties revealed a pronounced dependence upon embedding of Fe and Au nanoparticles in both polymer matrices.
32434157	8	74	theme	ions	1602:1605	arg1	behaviors					1584:1592	the special release behaviors	1564:1592	the special release behaviors of iron ions from alginate gels	1564:1624	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	11	75	theme	suitable	2185:2192	arg1	Fe					2117:2118	the laser-generated Fe or Au nanoparticle-loaded alginate composites	2097:2164	Fe	2117:2118	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	11	75	theme	suitable	2185:2192	arg1	bioink					2194:2199	a suitable bioink	2183:2199	a suitable bioink for 3D printing	2183:2215	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	11	75	theme	suitable	2185:2192	arg1	composites					2155:2164	the laser-generated Fe or Au nanoparticle-loaded alginate composites	2097:2164	composites	2155:2164	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	9	76	theme	collagen	1681:1688	arg1	BSA					1672:1674	BSA	1672:1674	BSA	1672:1674	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	76	theme	collagen	1681:1688	arg1	collagen					1681:1688	collagen I	1681:1690	collagen I	1681:1690	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	76	theme	collagen	1681:1688	arg1	albumin					1663:1669	adsorbed bovine serum albumin	1641:1669	adsorbed bovine serum albumin (BSA)	1641:1675	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	76	theme	collagen	1681:1688	arg1	amount					1631:1636	The amount	1627:1636	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites	1627:1745	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	76	theme	collagen	1681:1688	arg1	independent					1927:1937	independent	1927:1937	independent	1927:1937	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	12	77	from	bio-responses	2276:2288	arg1	healing					2358:2364	wound healing	2352:2364	wound healing	2352:2364	These findings are potentially relevant for ion-sensitive bio-responses in cell differentiation, endothelisation, vascularisation, or wound healing.
32434157	12	77	from	bio-responses	2276:2288	arg1	endothelisation					2315:2329	endothelisation	2315:2329	endothelisation	2315:2329	These findings are potentially relevant for ion-sensitive bio-responses in cell differentiation, endothelisation, vascularisation, or wound healing.
32434157	12	77	from	bio-responses	2276:2288	arg1	vascularisation					2332:2346	vascularisation	2332:2346	vascularisation	2332:2346	These findings are potentially relevant for ion-sensitive bio-responses in cell differentiation, endothelisation, vascularisation, or wound healing.
32434157	12	77	from	bio-responses	2276:2288	arg1	differentiation					2298:2312	cell differentiation	2293:2312	cell differentiation	2293:2312	These findings are potentially relevant for ion-sensitive bio-responses in cell differentiation, endothelisation, vascularisation, or wound healing.
32434157	8	78	theme	mechanistic	1312:1322	arg1	examination					1324:1334	A detailed mechanistic examination	1301:1334	A detailed mechanistic examination of iron the ion release process	1301:1366	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	6	79	from	nanoparticles	951:963	arg1	matrices					981:988	both polymer matrices	968:988	both polymer matrices	968:988	The physicochemical properties revealed a pronounced dependence upon embedding of Fe and Au nanoparticles in both polymer matrices.
32434157	2	80	theme	key	367:369	arg1	processes					371:379	two key processes	363:379	two key processes directing nanocomposite-cell interactions	363:421	In this context, the release of metal ions as well as protein adsorption capacity are hypothesized to be two key processes directing nanocomposite-cell interactions.
32434157	2	80	theme	key	367:369	arg1	release					279:285	the release	275:285	the release of metal ions as well as protein adsorption capacity	275:338	In this context, the release of metal ions as well as protein adsorption capacity are hypothesized to be two key processes directing nanocomposite-cell interactions.
32434157	5	81	theme	laser-generated	813:827	arg1	nanoparticles					829:841	laser-generated nanoparticles	813:841	laser-generated nanoparticles	813:841	Confocal microscopy revealed a three-dimensional homogeneous dispersion of laser-generated nanoparticles in the polymer.
32434157	11	82	theme	laser-generated	2101:2115	arg1	Fe					2117:2118	the laser-generated Fe or Au nanoparticle-loaded alginate composites	2097:2164	Fe	2117:2118	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	11	82	theme	laser-generated	2101:2115	arg1	bioink					2194:2199	a suitable bioink	2183:2199	a suitable bioink for 3D printing	2183:2215	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	11	82	theme	laser-generated	2101:2115	arg1	composites					2155:2164	the laser-generated Fe or Au nanoparticle-loaded alginate composites	2097:2164	composites	2155:2164	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	4	83	theme	Laser	565:569	arg1	ablation					571:578	Laser ablation	565:578	Laser ablation in macromolecule solutions	565:605	Laser ablation in macromolecule solutions was employed for synthesizing Au and Fe nanoparticle-loaded nanocomposites based on thermoplastic polyurethane (TPU) and alginate.
32434157	0	84	from	properties	139:148	arg1	release					36:42	Fe ion release	29:42	Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties	29:148	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	0	84	from	properties	139:148	arg1	mechanism					16:24	Matrix-specific mechanism	0:24	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.	0:149	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	10	85	theme	minute	2032:2037	arg1	loadings					2039:2046	minute loadings	2032:2046	minute loadings with Fe nanoparticles down to 200 ppm	2032:2084	Interestingly, these effects were already highly pronounced at minute loadings with Fe nanoparticles down to 200 ppm.
32434157	5	86	theme	three-dimensional	769:785	arg1	dispersion					799:808	a three-dimensional homogeneous dispersion	767:808	a three-dimensional homogeneous dispersion of laser-generated nanoparticles in the polymer	767:856	Confocal microscopy revealed a three-dimensional homogeneous dispersion of laser-generated nanoparticles in the polymer.
32434157	9	87	theme	control	1803:1809	arg1	polymers					1811:1818	the unloaded control polymers	1790:1818	the unloaded control polymers	1790:1818	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	8	88	theme	release	1576:1582	arg1	behaviors					1584:1592	the special release behaviors	1564:1592	the special release behaviors of iron ions from alginate gels	1564:1624	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	0	89	theme	nanoparticle-polymer	78:97	arg1	composites					99:108	laser-generated 3D-printable nanoparticle-polymer composites	49:108	laser-generated 3D-printable nanoparticle-polymer composites	49:108	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	2	90	theme	metal	290:294	arg1	ions					296:299	metal ions	290:299	metal ions	290:299	In this context, the release of metal ions as well as protein adsorption capacity are hypothesized to be two key processes directing nanocomposite-cell interactions.
32434157	8	91	theme	metals	1424:1429	arg1	potential					1411:1419	the redox potential	1401:1419	the redox potential of metals and diffusion of metal ions alone	1401:1463	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	91	theme	metals	1424:1429	arg1	it					1382:1383	it	1382:1383	it	1382:1383	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	91	theme	metals	1424:1429	arg1	solubility					1479:1488	the solubility	1475:1488	the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels	1475:1624	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	0	92	from	mechanism	16:24	arg1	composites					99:108	laser-generated 3D-printable nanoparticle-polymer composites	49:108	laser-generated 3D-printable nanoparticle-polymer composites	49:108	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	0	92	from	mechanism	16:24	arg1	properties					139:148	their protein adsorption properties	114:148	their protein adsorption properties	114:148	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	8	93	theme	diffusion	1435:1443	arg1	potential					1411:1419	the redox potential	1401:1419	the redox potential of metals and diffusion of metal ions alone	1401:1463	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	93	theme	diffusion	1435:1443	arg1	it					1382:1383	it	1382:1383	it	1382:1383	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	93	theme	diffusion	1435:1443	arg1	solubility					1479:1488	the solubility	1475:1488	the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels	1475:1624	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	0	94	theme	protein	120:126	arg1	properties					139:148	their protein adsorption properties	114:148	their protein adsorption properties	114:148	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	9	95	from	amount	1631:1636	arg1	surface					1699:1705	the surface	1695:1705	the surface of both the alginate and TPU composites	1695:1745	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	8	96	theme	alginate	1612:1619	arg1	gels					1621:1624	alginate gels	1612:1624	alginate gels	1612:1624	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	12	97	theme	cell	2293:2296	arg1	differentiation					2298:2312	cell differentiation	2293:2312	cell differentiation	2293:2312	These findings are potentially relevant for ion-sensitive bio-responses in cell differentiation, endothelisation, vascularisation, or wound healing.
32434157	8	98	theme	metal	1448:1452	arg1	ions					1454:1457	metal ions	1448:1457	metal ions alone	1448:1463	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	10	99	from	loadings	2039:2046	arg1	pronounced					2018:2027	pronounced	2018:2027	pronounced	2018:2027	Interestingly, these effects were already highly pronounced at minute loadings with Fe nanoparticles down to 200 ppm.
32434157	11	100	theme	nanoparticle-loaded	2126:2144	arg1	Fe					2117:2118	the laser-generated Fe or Au nanoparticle-loaded alginate composites	2097:2164	Fe	2117:2118	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	11	100	theme	nanoparticle-loaded	2126:2144	arg1	bioink					2194:2199	a suitable bioink	2183:2199	a suitable bioink for 3D printing	2183:2215	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	11	100	theme	nanoparticle-loaded	2126:2144	arg1	composites					2155:2164	the laser-generated Fe or Au nanoparticle-loaded alginate composites	2097:2164	composites	2155:2164	Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing.
32434157	7	101	theme	static	1071:1076	arg1	conditions					1078:1087	static conditions	1071:1087	static conditions	1071:1087	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	9	102	theme	bovine	1650:1655	arg1	BSA					1672:1674	BSA	1672:1674	BSA	1672:1674	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	102	theme	bovine	1650:1655	arg1	albumin					1663:1669	adsorbed bovine serum albumin	1641:1669	adsorbed bovine serum albumin (BSA)	1641:1675	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	3	103	with	kinetics	511:518	arg1	adsorption					553:562	protein adsorption	545:562	protein adsorption	545:562	The objective of this study is to understand the polymer-matrix effects on ion release kinetics and their relations with protein adsorption.
32434157	3	104	theme	polymer-matrix	473:486	arg1	effects					488:494	the polymer-matrix effects	469:494	the polymer-matrix effects on ion release kinetics and their relations with protein adsorption	469:562	The objective of this study is to understand the polymer-matrix effects on ion release kinetics and their relations with protein adsorption.
32434157	0	105	theme	Fe	29:30	arg1	release					36:42	Fe ion release	29:42	Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties	29:148	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	9	106	theme	albumin	1663:1669	arg1	BSA					1672:1674	BSA	1672:1674	BSA	1672:1674	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	106	theme	albumin	1663:1669	arg1	collagen					1681:1688	collagen I	1681:1690	collagen I	1681:1690	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	106	theme	albumin	1663:1669	arg1	albumin					1663:1669	adsorbed bovine serum albumin	1641:1669	adsorbed bovine serum albumin (BSA)	1641:1675	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	106	theme	albumin	1663:1669	arg1	amount					1631:1636	The amount	1627:1636	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites	1627:1745	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	106	theme	albumin	1663:1669	arg1	independent					1927:1937	independent	1927:1937	independent	1927:1937	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	9	107	theme	ions	1882:1885	arg1	concentration					1853:1865	the concentration	1849:1865	the concentration of released Fe ions and the porosity of composites	1849:1916	The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge.
32434157	4	108	theme	Au	637:638	arg1	nanocomposites					667:680	Au and Fe nanoparticle-loaded nanocomposites	637:680	Au and Fe nanoparticle-loaded nanocomposites based on thermoplastic polyurethane (TPU) and alginate	637:735	Laser ablation in macromolecule solutions was employed for synthesizing Au and Fe nanoparticle-loaded nanocomposites based on thermoplastic polyurethane (TPU) and alginate.
32434157	0	109	theme	release	36:42	arg1	mechanism					16:24	Matrix-specific mechanism	0:24	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.	0:149	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	4	110	theme	macromolecule	583:595	arg1	solutions					597:605	macromolecule solutions	583:605	macromolecule solutions	583:605	Laser ablation in macromolecule solutions was employed for synthesizing Au and Fe nanoparticle-loaded nanocomposites based on thermoplastic polyurethane (TPU) and alginate.
32434157	3	111	theme	release	503:509	arg1	kinetics					511:518	ion release kinetics	499:518	ion release kinetics	499:518	The objective of this study is to understand the polymer-matrix effects on ion release kinetics and their relations with protein adsorption.
32434157	0	112	theme	laser-generated	49:63	arg1	composites					99:108	laser-generated 3D-printable nanoparticle-polymer composites	49:108	laser-generated 3D-printable nanoparticle-polymer composites	49:108	Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties.
32434157	6	113	theme	polymer	973:979	arg1	matrices					981:988	both polymer matrices	968:988	both polymer matrices	968:988	The physicochemical properties revealed a pronounced dependence upon embedding of Fe and Au nanoparticles in both polymer matrices.
32434157	8	114	theme	oxides	1504:1509	arg1	potential					1411:1419	the redox potential	1401:1419	the redox potential of metals and diffusion of metal ions alone	1401:1463	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	114	theme	oxides	1504:1509	arg1	it					1382:1383	it	1382:1383	it	1382:1383	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	114	theme	oxides	1504:1509	arg1	solubility					1479:1488	the solubility	1475:1488	the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels	1475:1624	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	6	115	theme	physicochemical	863:877	arg1	properties					879:888	The physicochemical properties	859:888	The physicochemical properties	859:888	The physicochemical properties revealed a pronounced dependence upon embedding of Fe and Au nanoparticles in both polymer matrices.
32434157	3	116	theme	protein	545:551	arg1	adsorption					553:562	protein adsorption	545:562	protein adsorption	545:562	The objective of this study is to understand the polymer-matrix effects on ion release kinetics and their relations with protein adsorption.
32434157	8	117	theme	affinity	1515:1522	arg1	potential					1411:1419	the redox potential	1401:1419	the redox potential of metals and diffusion of metal ions alone	1401:1463	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	117	theme	affinity	1515:1522	arg1	it					1382:1383	it	1382:1383	it	1382:1383	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	8	117	theme	affinity	1515:1522	arg1	solubility					1479:1488	the solubility	1475:1488	the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels	1475:1624	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	7	118	theme	ion	1019:1021	arg1	concentration					1023:1035	the total Fe ion concentration	1006:1035	the total Fe ion concentration released from alginate gels under static conditions	1006:1087	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
32434157	6	119	theme	Au	948:949	arg1	nanoparticles					951:963	Fe and Au nanoparticles	941:963	Fe and Au nanoparticles in both polymer matrices	941:988	The physicochemical properties revealed a pronounced dependence upon embedding of Fe and Au nanoparticles in both polymer matrices.
32434157	8	120	theme	metal	1527:1531	arg1	ions					1533:1536	metal ions	1527:1536	metal ions	1527:1536	A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels.
32434157	3	121	from	effects	488:494	arg1	kinetics					511:518	ion release kinetics	499:518	ion release kinetics	499:518	The objective of this study is to understand the polymer-matrix effects on ion release kinetics and their relations with protein adsorption.
32434157	3	121	from	effects	488:494	arg1	relations					530:538	their relations	524:538	their relations with protein adsorption	524:562	The objective of this study is to understand the polymer-matrix effects on ion release kinetics and their relations with protein adsorption.
32434157	7	122	theme	total	1010:1014	arg1	concentration					1023:1035	the total Fe ion concentration	1006:1035	the total Fe ion concentration released from alginate gels under static conditions	1006:1087	Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load).
33953277	3	0	theme	Antimicrobial	546:558	arg1	activity					560:567	Antimicrobial activity	546:567	Antimicrobial activity	546:567	Antimicrobial activity was tested for both Cs-NP's and Cs-CuO-NP's via minimum inhibition concentration and zone analysis against fungus, gram-positive and gram-negative.
33953277	1	1	theme	biological	271:280	arg1	activity					282:289	the biological activity	267:289	the biological activity	267:289	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	7	2	theme	hypercholesteremia	1527:1544	arg1	samples					1552:1558	hypercholesteremia blood samples	1527:1558	hypercholesteremia blood samples	1527:1558	Cs-NP's success in decreasing the clotting time for healthy and diabetic blood acting as a procoagulant agent while adding biogenic CuO-NP's to Cs-NP's increased clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples.
33953277	4	3	theme	high	755:758	arg1	sensitivity					760:770	high sensitivity	755:770	high sensitivity of Cs-CuO-NP's to all microorganisms tested in a concentration less than 20,000 mg/L	755:855	The antimicrobial test results showed high sensitivity of Cs-CuO-NP's to all microorganisms tested in a concentration less than 20,000 mg/L, while the sensitivity of Cs-NP's against all microorganisms under the test started from a concentration of 20,000-40,000 mg/L except for the C. albicans species.
33953277	4	4	dep	C.	999:1000	arg1	albicans					1002:1009	albicans	1002:1009	albicans	1002:1009	The antimicrobial test results showed high sensitivity of Cs-CuO-NP's to all microorganisms tested in a concentration less than 20,000 mg/L, while the sensitivity of Cs-NP's against all microorganisms under the test started from a concentration of 20,000-40,000 mg/L except for the C. albicans species.
33953277	7	5	theme	anti-coagulant	1502:1515	arg1	agent					1517:1521	an anti-coagulant agent	1499:1521	an anti-coagulant agent for hypercholesteremia blood samples	1499:1558	Cs-NP's success in decreasing the clotting time for healthy and diabetic blood acting as a procoagulant agent while adding biogenic CuO-NP's to Cs-NP's increased clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples.
33953277	5	6	theme	platelet	1087:1094	arg1	count					1096:1100	platelet count	1087:1100	platelet count	1087:1100	The hematological activity was also tested via measuring the RBCs, platelet count, and clotting time against healthy, diabetic, and hypercholesteremia blood samples.
33953277	5	7	theme	hematological	1024:1036	arg1	activity					1038:1045	The hematological activity	1020:1045	The hematological activity	1020:1045	The hematological activity was also tested via measuring the RBCs, platelet count, and clotting time against healthy, diabetic, and hypercholesteremia blood samples.
33953277	7	8	theme	biogenic	1431:1438	arg1	CuO-NP					1440:1445	biogenic CuO-NP's	1431:1447	biogenic CuO-NP's	1431:1447	Cs-NP's success in decreasing the clotting time for healthy and diabetic blood acting as a procoagulant agent while adding biogenic CuO-NP's to Cs-NP's increased clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples.
33953277	0	9	theme	nano-copper	95:105	arg1	composite					107:115	its nano-copper composite	91:115	its nano-copper composite	91:115	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	0	9	theme	nano-copper	95:105	arg1	activity					35:42	antimicrobial activity	21:42	antimicrobial activity	21:42	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	0	9	theme	nano-copper	95:105	arg1	pattern					62:68	hematological pattern	48:68	hematological pattern	48:68	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	6	10	theme	platelet	1232:1239	arg1	count					1241:1245	platelet count	1232:1245	platelet count	1232:1245	The measurement showed a decrease in RBCs and platelet count by adding Cs-NP's or Cs-CuO-NP's to the three blood samples.
33953277	1	11	theme	Cs-NP	294:298	arg1	's					299:300	Cs-NP's	294:300	Cs-NP's	294:300	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	4	12	theme	test	735:738	arg1	results					740:746	The antimicrobial test results	717:746	The antimicrobial test results	717:746	The antimicrobial test results showed high sensitivity of Cs-CuO-NP's to all microorganisms tested in a concentration less than 20,000 mg/L, while the sensitivity of Cs-NP's against all microorganisms under the test started from a concentration of 20,000-40,000 mg/L except for the C. albicans species.
33953277	5	13	theme	diabetic	1138:1145	arg1	samples					1177:1183	healthy, diabetic, and hypercholesteremia blood samples	1129:1183	healthy, diabetic, and hypercholesteremia blood samples	1129:1183	The hematological activity was also tested via measuring the RBCs, platelet count, and clotting time against healthy, diabetic, and hypercholesteremia blood samples.
33953277	5	14	theme	hypercholesteremia	1152:1169	arg1	samples					1177:1183	healthy, diabetic, and hypercholesteremia blood samples	1129:1183	healthy, diabetic, and hypercholesteremia blood samples	1129:1183	The hematological activity was also tested via measuring the RBCs, platelet count, and clotting time against healthy, diabetic, and hypercholesteremia blood samples.
33953277	6	15	theme	blood	1293:1297	arg1	samples					1299:1305	the three blood samples	1283:1305	the three blood samples	1283:1305	The measurement showed a decrease in RBCs and platelet count by adding Cs-NP's or Cs-CuO-NP's to the three blood samples.
33953277	4	16	theme	less	835:838	arg1	concentration					821:833	a concentration	819:833	a concentration less than 20,000 mg/L	819:855	The antimicrobial test results showed high sensitivity of Cs-CuO-NP's to all microorganisms tested in a concentration less than 20,000 mg/L, while the sensitivity of Cs-NP's against all microorganisms under the test started from a concentration of 20,000-40,000 mg/L except for the C. albicans species.
33953277	5	17	theme	blood	1171:1175	arg1	samples					1177:1183	healthy, diabetic, and hypercholesteremia blood samples	1129:1183	healthy, diabetic, and hypercholesteremia blood samples	1129:1183	The hematological activity was also tested via measuring the RBCs, platelet count, and clotting time against healthy, diabetic, and hypercholesteremia blood samples.
33953277	1	18	theme	pomegranate	200:210	arg1	agents					249:254	green precipitating agents	229:254	green precipitating agents	229:254	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	1	18	theme	pomegranate	200:210	arg1	extract					218:224	pomegranate peels extract	200:224	pomegranate peels extract	200:224	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	1	19	theme	's	299:300	arg1	activity					282:289	the biological activity	267:289	the biological activity	267:289	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	1	20	theme	peels	212:216	arg1	agents					249:254	green precipitating agents	229:254	green precipitating agents	229:254	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	1	20	theme	peels	212:216	arg1	extract					218:224	pomegranate peels extract	200:224	pomegranate peels extract	200:224	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	0	21	theme	antimicrobial	21:33	arg1	activity					35:42	antimicrobial activity	21:42	antimicrobial activity	21:42	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	7	22	theme	diabetic	1372:1379	arg1	blood					1381:1385	healthy and diabetic blood	1360:1385	healthy and diabetic blood acting as a procoagulant agent	1360:1416	Cs-NP's success in decreasing the clotting time for healthy and diabetic blood acting as a procoagulant agent while adding biogenic CuO-NP's to Cs-NP's increased clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples.
33953277	3	23	theme	inhibition	625:634	arg1	concentration					636:648	minimum inhibition concentration	617:648	minimum inhibition concentration	617:648	Antimicrobial activity was tested for both Cs-NP's and Cs-CuO-NP's via minimum inhibition concentration and zone analysis against fungus, gram-positive and gram-negative.
33953277	1	24	theme	Novel	118:122	arg1	Cs-CuO					173:178	Cs-CuO	173:178	Cs-CuO	173:178	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	1	24	theme	Novel	118:122	arg1	nanocomposite					158:170	Novel synthesized Chitosan-Copper oxide nanocomposite	118:170	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO)	118:179	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	6	25	from	decrease	1211:1218	arg1	RBCs					1223:1226	RBCs	1223:1226	RBCs	1223:1226	The measurement showed a decrease in RBCs and platelet count by adding Cs-NP's or Cs-CuO-NP's to the three blood samples.
33953277	6	25	from	decrease	1211:1218	arg1	count					1241:1245	platelet count	1232:1245	platelet count	1232:1245	The measurement showed a decrease in RBCs and platelet count by adding Cs-NP's or Cs-CuO-NP's to the three blood samples.
33953277	7	26	theme	clotting	1342:1349	arg1	time					1351:1354	the clotting time	1338:1354	the clotting time for healthy and diabetic blood acting as a procoagulant agent	1338:1416	Cs-NP's success in decreasing the clotting time for healthy and diabetic blood acting as a procoagulant agent while adding biogenic CuO-NP's to Cs-NP's increased clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples.
33953277	4	27	theme	C.	999:1000	arg1	species					1011:1017	the C. albicans species	995:1017	the C. albicans species	995:1017	The antimicrobial test results showed high sensitivity of Cs-CuO-NP's to all microorganisms tested in a concentration less than 20,000 mg/L, while the sensitivity of Cs-NP's against all microorganisms under the test started from a concentration of 20,000-40,000 mg/L except for the C. albicans species.
33953277	3	28	theme	gram-negative	702:714	arg1	fungus					676:681	fungus	676:681	fungus	676:681	Antimicrobial activity was tested for both Cs-NP's and Cs-CuO-NP's via minimum inhibition concentration and zone analysis against fungus, gram-positive and gram-negative.
33953277	4	29	theme	antimicrobial	721:733	arg1	results					740:746	The antimicrobial test results	717:746	The antimicrobial test results	717:746	The antimicrobial test results showed high sensitivity of Cs-CuO-NP's to all microorganisms tested in a concentration less than 20,000 mg/L, while the sensitivity of Cs-NP's against all microorganisms under the test started from a concentration of 20,000-40,000 mg/L except for the C. albicans species.
33953277	1	30	theme	green	229:233	arg1	agents					249:254	green precipitating agents	229:254	green precipitating agents	229:254	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	1	30	theme	green	229:233	arg1	extract					218:224	pomegranate peels extract	200:224	pomegranate peels extract	200:224	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	0	31	theme	activity	35:42	arg1	composite					107:115	its nano-copper composite	91:115	its nano-copper composite	91:115	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	0	31	theme	activity	35:42	arg1	Investigation					0:12	Investigation	0:12	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan	0:85	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	0	31	theme	activity	35:42	arg1	activity					35:42	antimicrobial activity	21:42	antimicrobial activity	21:42	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	0	31	theme	activity	35:42	arg1	pattern					62:68	hematological pattern	48:68	hematological pattern	48:68	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	2	32	theme	significant	499:509	arg1	characters					511:520	all the significant characters	491:520	all the significant characters of those nanoparticles	491:543	The characterization of biogenic nanoparticles Cs-NP's and Cs-CuO-NP's was investigated structurally, morphologically to determine all the significant characters of those nanoparticles.
33953277	7	33	theme	healthy	1360:1366	arg1	blood					1381:1385	healthy and diabetic blood	1360:1385	healthy and diabetic blood acting as a procoagulant agent	1360:1416	Cs-NP's success in decreasing the clotting time for healthy and diabetic blood acting as a procoagulant agent while adding biogenic CuO-NP's to Cs-NP's increased clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples.
33953277	7	34	theme	procoagulant	1399:1410	arg1	agent					1412:1416	a procoagulant agent	1397:1416	a procoagulant agent	1397:1416	Cs-NP's success in decreasing the clotting time for healthy and diabetic blood acting as a procoagulant agent while adding biogenic CuO-NP's to Cs-NP's increased clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples.
33953277	1	35	theme	precipitating	235:247	arg1	agents					249:254	green precipitating agents	229:254	green precipitating agents	229:254	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	1	35	theme	precipitating	235:247	arg1	extract					218:224	pomegranate peels extract	200:224	pomegranate peels extract	200:224	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	0	36	theme	pattern	62:68	arg1	composite					107:115	its nano-copper composite	91:115	its nano-copper composite	91:115	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	0	36	theme	pattern	62:68	arg1	Investigation					0:12	Investigation	0:12	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan	0:85	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	0	36	theme	pattern	62:68	arg1	activity					35:42	antimicrobial activity	21:42	antimicrobial activity	21:42	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	0	36	theme	pattern	62:68	arg1	pattern					62:68	hematological pattern	48:68	hematological pattern	48:68	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	3	37	theme	gram-positive	684:696	arg1	fungus					676:681	fungus	676:681	fungus	676:681	Antimicrobial activity was tested for both Cs-NP's and Cs-CuO-NP's via minimum inhibition concentration and zone analysis against fungus, gram-positive and gram-negative.
33953277	3	38	theme	minimum	617:623	arg1	concentration					636:648	minimum inhibition concentration	617:648	minimum inhibition concentration	617:648	Antimicrobial activity was tested for both Cs-NP's and Cs-CuO-NP's via minimum inhibition concentration and zone analysis against fungus, gram-positive and gram-negative.
33953277	7	39	theme	clotting	1470:1477	arg1	time					1479:1482	clotting time	1470:1482	clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples	1470:1558	Cs-NP's success in decreasing the clotting time for healthy and diabetic blood acting as a procoagulant agent while adding biogenic CuO-NP's to Cs-NP's increased clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples.
33953277	1	40	theme	synthesized	124:134	arg1	Cs-CuO					173:178	Cs-CuO	173:178	Cs-CuO	173:178	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	1	40	theme	synthesized	124:134	arg1	nanocomposite					158:170	Novel synthesized Chitosan-Copper oxide nanocomposite	118:170	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO)	118:179	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	0	41	theme	hematological	48:60	arg1	pattern					62:68	hematological pattern	48:68	hematological pattern	48:68	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	0	42	dep	activity	35:42	arg1	the					17:19	the	17:19	the	17:19	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	1	43	theme	Chitosan-Copper	136:150	arg1	Cs-CuO					173:178	Cs-CuO	173:178	Cs-CuO	173:178	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	1	43	theme	Chitosan-Copper	136:150	arg1	nanocomposite					158:170	Novel synthesized Chitosan-Copper oxide nanocomposite	118:170	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO)	118:179	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	1	44	theme	ionic	337:341	arg1	method					352:357	the ionic gelation method	333:357	the ionic gelation method	333:357	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	4	45	theme	20,000-40,000 mg/L	965:982	arg1	concentration					948:960	a concentration	946:960	a concentration of 20,000-40,000 mg/L	946:982	The antimicrobial test results showed high sensitivity of Cs-CuO-NP's to all microorganisms tested in a concentration less than 20,000 mg/L, while the sensitivity of Cs-NP's against all microorganisms under the test started from a concentration of 20,000-40,000 mg/L except for the C. albicans species.
33953277	1	46	theme	oxide	152:156	arg1	Cs-CuO					173:178	Cs-CuO	173:178	Cs-CuO	173:178	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	1	46	theme	oxide	152:156	arg1	nanocomposite					158:170	Novel synthesized Chitosan-Copper oxide nanocomposite	118:170	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO)	118:179	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	7	47	theme	Cs-NP	1452:1456	arg1	's					1457:1458	Cs-NP's	1452:1458	Cs-NP's	1452:1458	Cs-NP's success in decreasing the clotting time for healthy and diabetic blood acting as a procoagulant agent while adding biogenic CuO-NP's to Cs-NP's increased clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples.
33953277	5	48	theme	clotting	1107:1114	arg1	time					1116:1119	clotting time	1107:1119	clotting time	1107:1119	The hematological activity was also tested via measuring the RBCs, platelet count, and clotting time against healthy, diabetic, and hypercholesteremia blood samples.
33953277	5	49	theme	healthy	1129:1135	arg1	samples					1177:1183	healthy, diabetic, and hypercholesteremia blood samples	1129:1183	healthy, diabetic, and hypercholesteremia blood samples	1129:1183	The hematological activity was also tested via measuring the RBCs, platelet count, and clotting time against healthy, diabetic, and hypercholesteremia blood samples.
33953277	0	50	theme	nano-chitosan	73:85	arg1	activity					35:42	antimicrobial activity	21:42	antimicrobial activity	21:42	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	0	50	theme	nano-chitosan	73:85	arg1	pattern					62:68	hematological pattern	48:68	hematological pattern	48:68	Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.
33953277	7	51	theme	blood	1546:1550	arg1	samples					1552:1558	hypercholesteremia blood samples	1527:1558	hypercholesteremia blood samples	1527:1558	Cs-NP's success in decreasing the clotting time for healthy and diabetic blood acting as a procoagulant agent while adding biogenic CuO-NP's to Cs-NP's increased clotting time considering as an anti-coagulant agent for hypercholesteremia blood samples.
33953277	3	52	theme	zone	654:657	arg1	analysis					659:666	zone analysis	654:666	zone analysis	654:666	Antimicrobial activity was tested for both Cs-NP's and Cs-CuO-NP's via minimum inhibition concentration and zone analysis against fungus, gram-positive and gram-negative.
33953277	2	53	theme	nanoparticles	393:405	arg1	characterization					364:379	The characterization	360:379	The characterization of biogenic nanoparticles Cs-NP's and Cs-CuO-NP's	360:429	The characterization of biogenic nanoparticles Cs-NP's and Cs-CuO-NP's was investigated structurally, morphologically to determine all the significant characters of those nanoparticles.
33953277	2	54	theme	nanoparticles	531:543	arg1	characters					511:520	all the significant characters	491:520	all the significant characters of those nanoparticles	491:543	The characterization of biogenic nanoparticles Cs-NP's and Cs-CuO-NP's was investigated structurally, morphologically to determine all the significant characters of those nanoparticles.
33953277	1	55	theme	gelation	343:350	arg1	method					352:357	the ionic gelation method	333:357	the ionic gelation method	333:357	Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method.
33953277	2	56	theme	biogenic	384:391	arg1	nanoparticles					393:405	biogenic nanoparticles Cs-NP's and Cs-CuO-NP's	384:429	biogenic nanoparticles Cs-NP's and Cs-CuO-NP's	384:429	The characterization of biogenic nanoparticles Cs-NP's and Cs-CuO-NP's was investigated structurally, morphologically to determine all the significant characters of those nanoparticles.
33735338	8	0	theme	Verrucomicrobia	1054:1068	arg1	abundance					1006:1014	the abundance	1002:1014	the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level)	1002:1083	Among fecal bacteria, the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level) increased and Ruminococcacere (phylum level) decreased in the feces of allergic mice.
33735338	6	1	theme	AhR-A	849:853	arg1	mice					855:858	AhR-A mice	849:858	AhR-A mice	849:858	This protective effect disappeared in AhR-A mice.
33735338	17	2	theme	FA	2466:2467	arg1	treatment					2453:2461	the treatment	2449:2461	the treatment of FA	2449:2467	FOS may serve as an effective tool for the treatment of FA by regulating immune and gut microbiota.
33735338	10	3	from	increase	1306:1313	arg1	abundance					1322:1330	the abundance	1318:1330	the abundance of Ruminococcacere (phylum level)	1318:1364	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	10	3	from	increase	1306:1313	arg1	abundance					1388:1396	the abundance	1384:1396	the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level)	1384:1465	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	10	4	theme	Akkermansiaceae	1401:1415	arg1	abundance					1388:1396	the abundance	1384:1396	the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level)	1384:1465	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	8	5	theme	phylum	1071:1076	arg1	Verrucomicrobia					1054:1068	Verrucomicrobia	1054:1068	Verrucomicrobia (phylum level)	1054:1083	Among fecal bacteria, the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level) increased and Ruminococcacere (phylum level) decreased in the feces of allergic mice.
33735338	8	5	theme	phylum	1071:1076	arg1	level					1078:1082	phylum level	1071:1082	phylum level	1071:1082	Among fecal bacteria, the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level) increased and Ruminococcacere (phylum level) decreased in the feces of allergic mice.
33735338	13	6	theme	relative	1844:1851	arg1	abundance					1853:1861	the relative abundance	1840:1861	the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn	1840:1939	Correlation analysis revealed a negative relationship between the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn, and a positive relationship with 5-HT.
33735338	4	7	theme	FA	549:550	arg1	model					540:544	a mouse model	532:544	a mouse model of FA supplemented with FOS	532:572	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	10	8	theme	Verrucomicrobia	1436:1450	arg1	abundance					1388:1396	the abundance	1384:1396	the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level)	1384:1465	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	11	9	theme	metabolites	1542:1552	arg1	analysis					1526:1533	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis	1468:1533	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites	1468:1552	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	10	10	theme	OVA	1280:1282	arg1	mice					1284:1287	OVA mice	1280:1287	OVA mice	1280:1287	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	2	11	theme	protective	276:285	arg1	mechanism					287:295	the protective mechanism	272:295	the protective mechanism of FOS against FA	272:313	Furthermore, the protective mechanism of FOS against FA is unclear.
33735338	2	11	theme	protective	276:285	arg1	unclear					318:324	unclear	318:324	unclear	318:324	Furthermore, the protective mechanism of FOS against FA is unclear.
33735338	6	12	theme	protective	816:825	arg1	effect					827:832	This protective effect	811:832	This protective effect	811:832	This protective effect disappeared in AhR-A mice.
33735338	1	13	theme	microbiota	187:196	arg1	composition					198:208	gut microbiota composition	183:208	gut microbiota composition	183:208	Fructooligosaccharides (FOS) can change gut microbiota composition and play a protective role in food allergy (FA).
33735338	14	14	theme	acid-associated	2045:2059	arg1	RORγt					2089:2093	RORγt	2089:2093	RORγt	2089:2093	FOS significantly reduced interleukin-17A (IL-17A) and retinoic acid-associated nuclear orphan receptor-γt (RORγt) in FOS mice but not in AhR-A mice.
33735338	14	14	theme	acid-associated	2045:2059	arg1	receptor-γt					2076:2086	retinoic acid-associated nuclear orphan receptor-γt	2036:2086	retinoic acid-associated nuclear orphan receptor-γt (RORγt)	2036:2094	FOS significantly reduced interleukin-17A (IL-17A) and retinoic acid-associated nuclear orphan receptor-γt (RORγt) in FOS mice but not in AhR-A mice.
33735338	8	15	theme	mice	1165:1168	arg1	feces					1147:1151	the feces	1143:1151	the feces of allergic mice	1143:1168	Among fecal bacteria, the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level) increased and Ruminococcacere (phylum level) decreased in the feces of allergic mice.
33735338	10	16	theme	phylum	1453:1458	arg1	Akkermansiaceae					1401:1415	Akkermansiaceae	1401:1415	Akkermansiaceae (family level)	1401:1430	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	10	16	theme	phylum	1453:1458	arg1	level					1460:1464	phylum level	1453:1464	phylum level	1453:1464	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	15	17	theme	Forkhead	2185:2192	arg1	Foxp3					2202:2206	Foxp3	2202:2206	Foxp3	2202:2206	FOS increased the level of interleukin-10 (IL-10) and Forkhead box P3 (Foxp3) in FOS mice but not in AhR-A mice.
33735338	15	17	theme	Forkhead	2185:2192	arg1	P3					2198:2199	Forkhead box P3	2185:2199	Forkhead box P3 (Foxp3)	2185:2207	FOS increased the level of interleukin-10 (IL-10) and Forkhead box P3 (Foxp3) in FOS mice but not in AhR-A mice.
33735338	16	18	theme	Trp	2393:2395	arg1	metabolites					2397:2407	Trp metabolites	2393:2407	Trp metabolites	2393:2407	These findings suggest that FOS ameliorates allergic symptoms and impacts Th17/Treg balance in mice by modulating the gut microbiota composition and Trp metabolites.
33735338	17	19	theme	effective	2430:2438	arg1	FOS					2410:2412	FOS	2410:2412	FOS	2410:2412	FOS may serve as an effective tool for the treatment of FA by regulating immune and gut microbiota.
33735338	17	19	theme	effective	2430:2438	arg1	tool					2440:2443	an effective tool	2427:2443	an effective tool for the treatment of FA	2427:2467	FOS may serve as an effective tool for the treatment of FA by regulating immune and gut microbiota.
33735338	4	20	theme	helper	599:604	arg1	Th					612:613	Th	612:613	Th	612:613	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	4	20	theme	helper	599:604	arg1	cell					606:609	T helper cell	597:609	T helper cell (Th) 17/regulatory T (Treg) cell balance	597:650	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	11	21	theme	FOS	1665:1667	arg1	mice					1669:1672	FOS mice	1665:1672	FOS mice	1665:1672	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	16	22	from	balance	2328:2334	arg1	mice					2339:2342	mice	2339:2342	mice	2339:2342	These findings suggest that FOS ameliorates allergic symptoms and impacts Th17/Treg balance in mice by modulating the gut microbiota composition and Trp metabolites.
33735338	13	23	theme	positive	1948:1955	arg1	relationship					1957:1968	a positive relationship	1946:1968	a positive relationship with 5-HT	1946:1978	Correlation analysis revealed a negative relationship between the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn, and a positive relationship with 5-HT.
33735338	4	24	theme	cell	639:642	arg1	balance					644:650	T helper cell (Th) 17/regulatory T (Treg) cell balance	597:650	T helper cell (Th) 17/regulatory T (Treg) cell balance	597:650	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	15	25	theme	AhR-A	2232:2236	arg1	mice					2238:2241	AhR-A mice	2232:2241	AhR-A mice	2232:2241	FOS increased the level of interleukin-10 (IL-10) and Forkhead box P3 (Foxp3) in FOS mice but not in AhR-A mice.
33735338	4	26	theme	T	630:630	arg1	balance					644:650	T helper cell (Th) 17/regulatory T (Treg) cell balance	597:650	T helper cell (Th) 17/regulatory T (Treg) cell balance	597:650	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	13	27	theme	Akkermansiaceae	1901:1915	arg1	abundance					1853:1861	the relative abundance	1840:1861	the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn	1840:1939	Correlation analysis revealed a negative relationship between the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn, and a positive relationship with 5-HT.
33735338	7	28	theme	bacterial	913:921	arg1	richness					923:930	significantly lower bacterial richness	893:930	significantly lower bacterial richness	893:930	The OVA mice manifestations had significantly lower bacterial richness, when compared to the normal control (NC) mice.
33735338	4	29	theme	Treg	633:636	arg1	balance					644:650	T helper cell (Th) 17/regulatory T (Treg) cell balance	597:650	T helper cell (Th) 17/regulatory T (Treg) cell balance	597:650	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	11	30	theme	OVA	1633:1635	arg1	mice					1637:1640	OVA mice	1633:1640	OVA mice	1633:1640	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	5	31	theme	dietary	699:705	arg1	intake					707:712	dietary intake	699:712	dietary intake of FOS	699:719	Our research studies showed that dietary intake of FOS provided moderate protection from the intestinal inflammation induced by ovalbumin (OVA).
33735338	13	32	theme	family	1918:1923	arg1	Akkermansiaceae					1901:1915	Akkermansiaceae	1901:1915	Akkermansiaceae (family level)	1901:1930	Correlation analysis revealed a negative relationship between the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn, and a positive relationship with 5-HT.
33735338	13	32	theme	family	1918:1923	arg1	level					1925:1929	family level	1918:1929	family level	1918:1929	Correlation analysis revealed a negative relationship between the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn, and a positive relationship with 5-HT.
33735338	0	33	theme	cell	100:103	arg1	balance					105:111	the Th17/Treg cell balance	86:111	the Th17/Treg cell balance using tryptophan metabolites	86:140	Fructooligosaccharides protect against OVA-induced food allergy in mice by regulating the Th17/Treg cell balance using tryptophan metabolites.
33735338	9	34	theme	FOS	1202:1204	arg1	treatment					1206:1214	FOS treatment	1202:1214	FOS treatment	1202:1214	These changes were reversed by FOS treatment.
33735338	16	35	theme	gut	2362:2364	arg1	composition					2377:2387	the gut microbiota composition	2358:2387	the gut microbiota composition	2358:2387	These findings suggest that FOS ameliorates allergic symptoms and impacts Th17/Treg balance in mice by modulating the gut microbiota composition and Trp metabolites.
33735338	5	36	theme	research	670:677	arg1	studies					679:685	Our research studies	666:685	Our research studies	666:685	Our research studies showed that dietary intake of FOS provided moderate protection from the intestinal inflammation induced by ovalbumin (OVA).
33735338	15	37	theme	P3	2198:2199	arg1	level					2149:2153	the level	2145:2153	the level of interleukin-10 (IL-10) and Forkhead box P3 (Foxp3)	2145:2207	FOS increased the level of interleukin-10 (IL-10) and Forkhead box P3 (Foxp3) in FOS mice but not in AhR-A mice.
33735338	12	38	theme	5-hydroxytryptamine	1709:1727	arg1	levels					1691:1696	the levels	1687:1696	the levels of Trp and 5-hydroxytryptamine (5-HT)	1687:1734	Conversely, the levels of Trp and 5-hydroxytryptamine (5-HT) were significantly increased in OVA mice.
33735338	7	39	theme	OVA	865:867	arg1	manifestations					874:887	The OVA mice manifestations	861:887	The OVA mice manifestations	861:887	The OVA mice manifestations had significantly lower bacterial richness, when compared to the normal control (NC) mice.
33735338	3	40	theme	tryptophan	363:372	arg1	metabolites					380:390	intestinal flora and tryptophan (Trp) metabolites	342:390	intestinal flora and tryptophan (Trp) metabolites	342:390	In this study, intestinal flora and tryptophan (Trp) metabolites were investigated in a mouse model with FA supplemented with FOS.
33735338	14	41	theme	FOS	2099:2101	arg1	mice					2103:2106	FOS mice	2099:2106	FOS mice	2099:2106	FOS significantly reduced interleukin-17A (IL-17A) and retinoic acid-associated nuclear orphan receptor-γt (RORγt) in FOS mice but not in AhR-A mice.
33735338	3	42	theme	flora	353:357	arg1	metabolites					380:390	intestinal flora and tryptophan (Trp) metabolites	342:390	intestinal flora and tryptophan (Trp) metabolites	342:390	In this study, intestinal flora and tryptophan (Trp) metabolites were investigated in a mouse model with FA supplemented with FOS.
33735338	0	43	theme	food	51:54	arg1	allergy					56:62	OVA-induced food allergy	39:62	OVA-induced food allergy in mice	39:70	Fructooligosaccharides protect against OVA-induced food allergy in mice by regulating the Th17/Treg cell balance using tryptophan metabolites.
33735338	12	44	theme	Trp	1701:1703	arg1	levels					1691:1696	the levels	1687:1696	the levels of Trp and 5-hydroxytryptamine (5-HT)	1687:1734	Conversely, the levels of Trp and 5-hydroxytryptamine (5-HT) were significantly increased in OVA mice.
33735338	16	45	theme	allergic	2288:2295	arg1	symptoms					2297:2304	allergic symptoms	2288:2304	allergic symptoms	2288:2304	These findings suggest that FOS ameliorates allergic symptoms and impacts Th17/Treg balance in mice by modulating the gut microbiota composition and Trp metabolites.
33735338	4	46	theme	hydrocarbon	486:496	arg1	receptor					498:505	aryl hydrocarbon receptor	481:505	aryl hydrocarbon receptor antagonists (AhR-A)	481:525	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	10	47	theme	gut	1235:1237	arg1	profiles					1250:1257	the gut microbiome profiles	1231:1257	the gut microbiome profiles that were altered in OVA mice	1231:1287	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	16	48	theme	Th17/Treg	2318:2326	arg1	balance					2328:2334	Th17/Treg balance	2318:2334	Th17/Treg balance in mice	2318:2342	These findings suggest that FOS ameliorates allergic symptoms and impacts Th17/Treg balance in mice by modulating the gut microbiota composition and Trp metabolites.
33735338	11	49	theme	spectrometry	1502:1513	arg1	analysis					1526:1533	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis	1468:1533	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites	1468:1552	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	14	50	theme	nuclear	2061:2067	arg1	RORγt					2089:2093	RORγt	2089:2093	RORγt	2089:2093	FOS significantly reduced interleukin-17A (IL-17A) and retinoic acid-associated nuclear orphan receptor-γt (RORγt) in FOS mice but not in AhR-A mice.
33735338	14	50	theme	nuclear	2061:2067	arg1	receptor-γt					2076:2086	retinoic acid-associated nuclear orphan receptor-γt	2036:2086	retinoic acid-associated nuclear orphan receptor-γt (RORγt)	2036:2094	FOS significantly reduced interleukin-17A (IL-17A) and retinoic acid-associated nuclear orphan receptor-γt (RORγt) in FOS mice but not in AhR-A mice.
33735338	11	51	theme	chromatography/tandem	1475:1495	arg1	LC-MS/MS					1516:1523	LC-MS/MS	1516:1523	LC-MS/MS	1516:1523	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	11	51	theme	chromatography/tandem	1475:1495	arg1	spectrometry					1502:1513	Liquid chromatography/tandem mass spectrometry	1468:1513	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites	1468:1552	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	4	52	theme	mouse	534:538	arg1	model					540:544	a mouse model	532:544	a mouse model of FA supplemented with FOS	532:572	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	14	53	theme	retinoic	2036:2043	arg1	RORγt					2089:2093	RORγt	2089:2093	RORγt	2089:2093	FOS significantly reduced interleukin-17A (IL-17A) and retinoic acid-associated nuclear orphan receptor-γt (RORγt) in FOS mice but not in AhR-A mice.
33735338	14	53	theme	retinoic	2036:2043	arg1	receptor-γt					2076:2086	retinoic acid-associated nuclear orphan receptor-γt	2036:2086	retinoic acid-associated nuclear orphan receptor-γt (RORγt)	2036:2094	FOS significantly reduced interleukin-17A (IL-17A) and retinoic acid-associated nuclear orphan receptor-γt (RORγt) in FOS mice but not in AhR-A mice.
33735338	17	54	theme	immune	2483:2488	arg1	microbiota					2498:2507	immune and gut microbiota	2483:2507	microbiota	2498:2507	FOS may serve as an effective tool for the treatment of FA by regulating immune and gut microbiota.
33735338	13	55	theme	negative	1810:1817	arg1	relationship					1819:1830	a negative relationship	1808:1830	a negative relationship between the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn	1808:1939	Correlation analysis revealed a negative relationship between the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn, and a positive relationship with 5-HT.
33735338	1	56	theme	gut	183:185	arg1	composition					198:208	gut microbiota composition	183:208	gut microbiota composition	183:208	Fructooligosaccharides (FOS) can change gut microbiota composition and play a protective role in food allergy (FA).
33735338	17	57	theme	gut	2494:2496	arg1	microbiota					2498:2507	immune and gut microbiota	2483:2507	microbiota	2498:2507	FOS may serve as an effective tool for the treatment of FA by regulating immune and gut microbiota.
33735338	4	58	theme	cell	606:609	arg1	balance					644:650	T helper cell (Th) 17/regulatory T (Treg) cell balance	597:650	T helper cell (Th) 17/regulatory T (Treg) cell balance	597:650	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	11	59	theme	Trp	1538:1540	arg1	metabolites					1542:1552	Trp metabolites	1538:1552	Trp metabolites	1538:1552	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	3	60	with	model	421:425	arg1	FA					432:433	FA	432:433	FA supplemented with FOS	432:455	In this study, intestinal flora and tryptophan (Trp) metabolites were investigated in a mouse model with FA supplemented with FOS.
33735338	13	61	theme	Correlation	1778:1788	arg1	analysis					1790:1797	Correlation analysis	1778:1797	Correlation analysis	1778:1797	Correlation analysis revealed a negative relationship between the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn, and a positive relationship with 5-HT.
33735338	2	62	theme	FOS	300:302	arg1	mechanism					287:295	the protective mechanism	272:295	the protective mechanism of FOS against FA	272:313	Furthermore, the protective mechanism of FOS against FA is unclear.
33735338	2	62	theme	FOS	300:302	arg1	unclear					318:324	unclear	318:324	unclear	318:324	Furthermore, the protective mechanism of FOS against FA is unclear.
33735338	10	63	dep	modulated	1221:1229	arg1	showed					1296:1301	showed	1296:1301	showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level)	1296:1465	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	5	64	theme	intestinal	759:768	arg1	inflammation					770:781	the intestinal inflammation	755:781	the intestinal inflammation induced by ovalbumin (OVA)	755:808	Our research studies showed that dietary intake of FOS provided moderate protection from the intestinal inflammation induced by ovalbumin (OVA).
33735338	8	65	theme	allergic	1156:1163	arg1	mice					1165:1168	allergic mice	1156:1168	allergic mice	1156:1168	Among fecal bacteria, the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level) increased and Ruminococcacere (phylum level) decreased in the feces of allergic mice.
33735338	7	66	contain	had	889:891	arg2	richness					923:930	significantly lower bacterial richness	893:930	significantly lower bacterial richness	893:930	The OVA mice manifestations had significantly lower bacterial richness, when compared to the normal control (NC) mice.
33735338	7	66	contain	had	889:891	arg1	manifestations					874:887	The OVA mice manifestations	861:887	The OVA mice manifestations	861:887	The OVA mice manifestations had significantly lower bacterial richness, when compared to the normal control (NC) mice.
33735338	15	67	theme	box	2194:2196	arg1	Foxp3					2202:2206	Foxp3	2202:2206	Foxp3	2202:2206	FOS increased the level of interleukin-10 (IL-10) and Forkhead box P3 (Foxp3) in FOS mice but not in AhR-A mice.
33735338	15	67	theme	box	2194:2196	arg1	P3					2198:2199	Forkhead box P3	2185:2199	Forkhead box P3 (Foxp3)	2185:2207	FOS increased the level of interleukin-10 (IL-10) and Forkhead box P3 (Foxp3) in FOS mice but not in AhR-A mice.
33735338	1	68	theme	protective	221:230	arg1	role					232:235	a protective role	219:235	a protective role	219:235	Fructooligosaccharides (FOS) can change gut microbiota composition and play a protective role in food allergy (FA).
33735338	8	69	theme	phylum	1116:1121	arg1	Ruminococcacere					1099:1113	Ruminococcacere	1099:1113	Ruminococcacere (phylum level)	1099:1128	Among fecal bacteria, the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level) increased and Ruminococcacere (phylum level) decreased in the feces of allergic mice.
33735338	8	69	theme	phylum	1116:1121	arg1	level					1123:1127	phylum level	1116:1127	phylum level	1116:1127	Among fecal bacteria, the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level) increased and Ruminococcacere (phylum level) decreased in the feces of allergic mice.
33735338	4	70	theme	T	597:597	arg1	Th					612:613	Th	612:613	Th	612:613	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	4	70	theme	T	597:597	arg1	cell					606:609	T helper cell	597:609	T helper cell (Th) 17/regulatory T (Treg) cell balance	597:650	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	7	71	theme	NC	970:971	arg1	mice					974:977	the normal control (NC) mice	950:977	the normal control (NC) mice	950:977	The OVA mice manifestations had significantly lower bacterial richness, when compared to the normal control (NC) mice.
33735338	7	72	theme	normal	954:959	arg1	mice					974:977	the normal control (NC) mice	950:977	the normal control (NC) mice	950:977	The OVA mice manifestations had significantly lower bacterial richness, when compared to the normal control (NC) mice.
33735338	7	73	theme	control	961:967	arg1	mice					974:977	the normal control (NC) mice	950:977	the normal control (NC) mice	950:977	The OVA mice manifestations had significantly lower bacterial richness, when compared to the normal control (NC) mice.
33735338	5	74	from	inflammation	770:781	arg1	protection					739:748	moderate protection	730:748	moderate protection from the intestinal inflammation induced by ovalbumin (OVA)	730:808	Our research studies showed that dietary intake of FOS provided moderate protection from the intestinal inflammation induced by ovalbumin (OVA).
33735338	15	75	theme	interleukin-10	2158:2171	arg1	level					2149:2153	the level	2145:2153	the level of interleukin-10 (IL-10) and Forkhead box P3 (Foxp3)	2145:2207	FOS increased the level of interleukin-10 (IL-10) and Forkhead box P3 (Foxp3) in FOS mice but not in AhR-A mice.
33735338	10	76	from	decrease	1372:1379	arg1	abundance					1322:1330	the abundance	1318:1330	the abundance of Ruminococcacere (phylum level)	1318:1364	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	10	76	from	decrease	1372:1379	arg1	abundance					1388:1396	the abundance	1384:1396	the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level)	1384:1465	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	4	77	theme	17/regulatory	616:628	arg1	balance					644:650	T helper cell (Th) 17/regulatory T (Treg) cell balance	597:650	T helper cell (Th) 17/regulatory T (Treg) cell balance	597:650	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	3	78	theme	intestinal	342:351	arg1	flora					353:357	intestinal flora	342:357	intestinal flora	342:357	In this study, intestinal flora and tryptophan (Trp) metabolites were investigated in a mouse model with FA supplemented with FOS.
33735338	0	79	theme	Th17/Treg	90:98	arg1	balance					105:111	the Th17/Treg cell balance	86:111	the Th17/Treg cell balance using tryptophan metabolites	86:140	Fructooligosaccharides protect against OVA-induced food allergy in mice by regulating the Th17/Treg cell balance using tryptophan metabolites.
33735338	13	80	theme	class	1884:1888	arg1	Verrucomicrobiae					1866:1881	Verrucomicrobiae	1866:1881	Verrucomicrobiae (class level)	1866:1895	Correlation analysis revealed a negative relationship between the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn, and a positive relationship with 5-HT.
33735338	13	80	theme	class	1884:1888	arg1	level					1890:1894	class level	1884:1894	class level	1884:1894	Correlation analysis revealed a negative relationship between the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn, and a positive relationship with 5-HT.
33735338	4	81	theme	aryl	481:484	arg1	receptor					498:505	aryl hydrocarbon receptor	481:505	aryl hydrocarbon receptor antagonists (AhR-A)	481:525	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	14	82	theme	AhR-A	2119:2123	arg1	mice					2125:2128	AhR-A mice	2119:2128	AhR-A mice	2119:2128	FOS significantly reduced interleukin-17A (IL-17A) and retinoic acid-associated nuclear orphan receptor-γt (RORγt) in FOS mice but not in AhR-A mice.
33735338	11	83	theme	mice	1637:1640	arg1	serum					1624:1628	the serum	1620:1628	the serum of OVA mice	1620:1640	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	15	84	theme	FOS	2212:2214	arg1	mice					2216:2219	FOS mice	2212:2219	FOS mice	2212:2219	FOS increased the level of interleukin-10 (IL-10) and Forkhead box P3 (Foxp3) in FOS mice but not in AhR-A mice.
33735338	7	85	theme	lower	907:911	arg1	richness					923:930	significantly lower bacterial richness	893:930	significantly lower bacterial richness	893:930	The OVA mice manifestations had significantly lower bacterial richness, when compared to the normal control (NC) mice.
33735338	16	86	theme	microbiota	2366:2375	arg1	composition					2377:2387	the gut microbiota composition	2358:2387	the gut microbiota composition	2358:2387	These findings suggest that FOS ameliorates allergic symptoms and impacts Th17/Treg balance in mice by modulating the gut microbiota composition and Trp metabolites.
33735338	11	87	from	reductions	1573:1582	arg1	level					1591:1595	the level	1587:1595	the level of kynurenine (kyn)	1587:1615	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	0	88	theme	tryptophan	119:128	arg1	metabolites					130:140	tryptophan metabolites	119:140	tryptophan metabolites	119:140	Fructooligosaccharides protect against OVA-induced food allergy in mice by regulating the Th17/Treg cell balance using tryptophan metabolites.
33735338	0	89	from	allergy	56:62	arg1	mice					67:70	mice	67:70	mice	67:70	Fructooligosaccharides protect against OVA-induced food allergy in mice by regulating the Th17/Treg cell balance using tryptophan metabolites.
33735338	10	90	theme	phylum	1352:1357	arg1	Ruminococcacere					1335:1349	Ruminococcacere	1335:1349	Ruminococcacere (phylum level)	1335:1364	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	10	90	theme	phylum	1352:1357	arg1	level					1359:1363	phylum level	1352:1363	phylum level	1352:1363	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	3	91	theme	mouse	415:419	arg1	model					421:425	a mouse model	413:425	a mouse model with FA supplemented with FOS	413:455	In this study, intestinal flora and tryptophan (Trp) metabolites were investigated in a mouse model with FA supplemented with FOS.
33735338	5	92	theme	moderate	730:737	arg1	protection					739:748	moderate protection	730:748	moderate protection from the intestinal inflammation induced by ovalbumin (OVA)	730:808	Our research studies showed that dietary intake of FOS provided moderate protection from the intestinal inflammation induced by ovalbumin (OVA).
33735338	8	93	theme	fecal	986:990	arg1	bacteria					992:999	fecal bacteria	986:999	fecal bacteria	986:999	Among fecal bacteria, the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level) increased and Ruminococcacere (phylum level) decreased in the feces of allergic mice.
33735338	7	94	theme	mice	869:872	arg1	manifestations					874:887	The OVA mice manifestations	861:887	The OVA mice manifestations	861:887	The OVA mice manifestations had significantly lower bacterial richness, when compared to the normal control (NC) mice.
33735338	10	95	theme	Ruminococcacere	1335:1349	arg1	abundance					1322:1330	the abundance	1318:1330	the abundance of Ruminococcacere (phylum level)	1318:1364	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	0	96	theme	OVA-induced	39:49	arg1	allergy					56:62	OVA-induced food allergy	39:62	OVA-induced food allergy in mice	39:70	Fructooligosaccharides protect against OVA-induced food allergy in mice by regulating the Th17/Treg cell balance using tryptophan metabolites.
33735338	13	97	with	relationship	1957:1968	arg1	5-HT					1975:1978	5-HT	1975:1978	5-HT	1975:1978	Correlation analysis revealed a negative relationship between the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn, and a positive relationship with 5-HT.
33735338	4	98	theme	receptor	498:505	arg1	antagonists					507:517	aryl hydrocarbon receptor antagonists	481:517	aryl hydrocarbon receptor antagonists (AhR-A)	481:525	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	4	98	theme	receptor	498:505	arg1	AhR-A					520:524	AhR-A	520:524	AhR-A	520:524	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	12	99	theme	OVA	1768:1770	arg1	mice					1772:1775	OVA mice	1768:1775	OVA mice	1768:1775	Conversely, the levels of Trp and 5-hydroxytryptamine (5-HT) were significantly increased in OVA mice.
33735338	11	100	theme	significant	1561:1571	arg1	reductions					1573:1582	significant reductions	1561:1582	significant reductions in the level of kynurenine (kyn)	1561:1615	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	10	101	theme	microbiome	1239:1248	arg1	profiles					1250:1257	the gut microbiome profiles	1231:1257	the gut microbiome profiles that were altered in OVA mice	1231:1287	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	5	102	theme	FOS	717:719	arg1	intake					707:712	dietary intake	699:712	dietary intake of FOS	699:719	Our research studies showed that dietary intake of FOS provided moderate protection from the intestinal inflammation induced by ovalbumin (OVA).
33735338	4	103	dep	injected	472:479	arg1	Meanwhile					458:466	Meanwhile	458:466	Meanwhile	458:466	Meanwhile, we injected aryl hydrocarbon receptor antagonists (AhR-A) into a mouse model of FA supplemented with FOS to investigate whether T helper cell (Th) 17/regulatory T (Treg) cell balance was affected.
33735338	8	104	theme	Akkermansiaceae	1019:1033	arg1	abundance					1006:1014	the abundance	1002:1014	the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level)	1002:1083	Among fecal bacteria, the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level) increased and Ruminococcacere (phylum level) decreased in the feces of allergic mice.
33735338	14	105	theme	orphan	2069:2074	arg1	RORγt					2089:2093	RORγt	2089:2093	RORγt	2089:2093	FOS significantly reduced interleukin-17A (IL-17A) and retinoic acid-associated nuclear orphan receptor-γt (RORγt) in FOS mice but not in AhR-A mice.
33735338	14	105	theme	orphan	2069:2074	arg1	receptor-γt					2076:2086	retinoic acid-associated nuclear orphan receptor-γt	2036:2086	retinoic acid-associated nuclear orphan receptor-γt (RORγt)	2036:2094	FOS significantly reduced interleukin-17A (IL-17A) and retinoic acid-associated nuclear orphan receptor-γt (RORγt) in FOS mice but not in AhR-A mice.
33735338	11	106	theme	kynurenine	1600:1609	arg1	level					1591:1595	the level	1587:1595	the level of kynurenine (kyn)	1587:1615	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	13	107	theme	Verrucomicrobiae	1866:1881	arg1	abundance					1853:1861	the relative abundance	1840:1861	the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn	1840:1939	Correlation analysis revealed a negative relationship between the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn, and a positive relationship with 5-HT.
33735338	8	108	theme	family	1036:1041	arg1	Akkermansiaceae					1019:1033	Akkermansiaceae	1019:1033	Akkermansiaceae (family level)	1019:1048	Among fecal bacteria, the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level) increased and Ruminococcacere (phylum level) decreased in the feces of allergic mice.
33735338	8	108	theme	family	1036:1041	arg1	level					1043:1047	family level	1036:1047	family level	1036:1047	Among fecal bacteria, the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level) increased and Ruminococcacere (phylum level) decreased in the feces of allergic mice.
33735338	11	109	theme	mass	1497:1500	arg1	LC-MS/MS					1516:1523	LC-MS/MS	1516:1523	LC-MS/MS	1516:1523	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	11	109	theme	mass	1497:1500	arg1	spectrometry					1502:1513	Liquid chromatography/tandem mass spectrometry	1468:1513	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites	1468:1552	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	1	110	theme	food	240:243	arg1	allergy					245:251	food allergy	240:251	food allergy (FA)	240:256	Fructooligosaccharides (FOS) can change gut microbiota composition and play a protective role in food allergy (FA).
33735338	1	110	theme	food	240:243	arg1	FA					254:255	FA	254:255	FA	254:255	Fructooligosaccharides (FOS) can change gut microbiota composition and play a protective role in food allergy (FA).
33735338	13	111	with	relationship	1819:1830	arg1	5-HT					1975:1978	5-HT	1975:1978	5-HT	1975:1978	Correlation analysis revealed a negative relationship between the relative abundance of Verrucomicrobiae (class level) and Akkermansiaceae (family level) with kyn, and a positive relationship with 5-HT.
33735338	10	112	theme	family	1418:1423	arg1	Akkermansiaceae					1401:1415	Akkermansiaceae	1401:1415	Akkermansiaceae (family level)	1401:1430	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	10	112	theme	family	1418:1423	arg1	level					1425:1429	family level	1418:1429	family level	1418:1429	FOS modulated the gut microbiome profiles that were altered in OVA mice, which showed an increase in the abundance of Ruminococcacere (phylum level) and a decrease in the abundance of Akkermansiaceae (family level) and Verrucomicrobia (phylum level).
33735338	11	113	theme	Liquid	1468:1473	arg1	LC-MS/MS					1516:1523	LC-MS/MS	1516:1523	LC-MS/MS	1516:1523	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
33735338	11	113	theme	Liquid	1468:1473	arg1	spectrometry					1502:1513	Liquid chromatography/tandem mass spectrometry	1468:1513	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites	1468:1552	Liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of Trp metabolites showed significant reductions in the level of kynurenine (kyn) in the serum of OVA mice, as compared to NC and FOS mice.
32227885	7	0	theme	sialic	1226:1231	arg1	acids					1233:1237	sialic acids	1226:1237	sialic acids	1226:1237	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	7	1	theme	components	1124:1133	arg1	finding					1107:1113	The finding	1103:1113	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria	1103:1207	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	1	2	theme	anaerobic	154:162	arg1	oxidation					173:181	anaerobic ammonium oxidation	154:181	anaerobic ammonium oxidation	154:181	Anammox (anaerobic ammonium oxidation) bacteria are important for the nitrogen cycle in both natural environments and wastewater treatment plants.
32227885	1	2	theme	anaerobic	154:162	arg1	Anammox					145:151	Anammox	145:151	Anammox (anaerobic ammonium oxidation) bacteria	145:191	Anammox (anaerobic ammonium oxidation) bacteria are important for the nitrogen cycle in both natural environments and wastewater treatment plants.
32227885	5	3	theme	%	909:909	arg1	equivalents					911:921	2.4% equivalents	906:921	2.4% equivalents of sulfated glycosaminoglycans	906:952	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	5	4	theme	acids	896:900	arg1	equivalents					911:921	2.4% equivalents	906:921	2.4% equivalents of sulfated glycosaminoglycans	906:952	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	5	4	theme	acids	896:900	arg1	equivalents					874:884	1.6% equivalents	869:884	1.6% equivalents of sialic acids	869:900	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	1	5	theme	ammonium	164:171	arg1	oxidation					173:181	anaerobic ammonium oxidation	154:181	anaerobic ammonium oxidation	154:181	Anammox (anaerobic ammonium oxidation) bacteria are important for the nitrogen cycle in both natural environments and wastewater treatment plants.
32227885	1	5	theme	ammonium	164:171	arg1	Anammox					145:151	Anammox	145:151	Anammox (anaerobic ammonium oxidation) bacteria	145:191	Anammox (anaerobic ammonium oxidation) bacteria are important for the nitrogen cycle in both natural environments and wastewater treatment plants.
32227885	7	6	from	function	1323:1330	arg1	communities					1345:1355	microbial communities	1335:1355	microbial communities	1335:1355	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	0	7	theme	Polymeric	96:104	arg1	Substances					106:115	the Extracellular Polymeric Substances	78:115	the Extracellular Polymeric Substances of Anammox Granular Sludge	78:142	Decorating the Anammox House: Sialic Acids and Sulfated Glycosaminoglycans in the Extracellular Polymeric Substances of Anammox Granular Sludge.
32227885	5	8	located	present	841:847	arg2	glycosaminoglycans					817:834	sulfated glycosaminoglycans	808:834	sulfated glycosaminoglycans	808:834	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	5	8	located	present	841:847	arg1	EPS					864:866	the anammox EPS	852:866	the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans)	852:953	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	5	8	located	present	841:847	arg2	acids					798:802	sialic acids	791:802	sialic acids	791:802	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	1	9	theme	wastewater	263:272	arg1	plants					284:289	wastewater treatment plants	263:289	wastewater treatment plants	263:289	Anammox (anaerobic ammonium oxidation) bacteria are important for the nitrogen cycle in both natural environments and wastewater treatment plants.
32227885	0	10	theme	Extracellular	82:94	arg1	Substances					106:115	the Extracellular Polymeric Substances	78:115	the Extracellular Polymeric Substances of Anammox Granular Sludge	78:142	Decorating the Anammox House: Sialic Acids and Sulfated Glycosaminoglycans in the Extracellular Polymeric Substances of Anammox Granular Sludge.
32227885	5	11	attach	present	841:847	arg2	glycosaminoglycans					817:834	sulfated glycosaminoglycans	808:834	sulfated glycosaminoglycans	808:834	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	5	11	attach	present	841:847	arg1	EPS					864:866	the anammox EPS	852:866	the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans)	852:953	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	5	11	attach	present	841:847	arg2	acids					798:802	sialic acids	791:802	sialic acids	791:802	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	3	12	theme	polymeric	501:509	arg1	substances					511:520	the extracellular polymeric substances	483:520	the extracellular polymeric substances (EPS)	483:526	To understand the formation of anammox aggregates, it is required to unravel the composition of the extracellular polymeric substances (EPS), which are produced by the bacteria to develop into aggregates and granules.
32227885	3	12	theme	polymeric	501:509	arg1	EPS					523:525	EPS	523:525	EPS	523:525	To understand the formation of anammox aggregates, it is required to unravel the composition of the extracellular polymeric substances (EPS), which are produced by the bacteria to develop into aggregates and granules.
32227885	7	13	from	systems	1369:1375	arg1	general					1380:1386	general	1380:1386	general	1380:1386	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	7	13	from	systems	1369:1375	arg1	communities					1345:1355	microbial communities	1335:1355	microbial communities	1335:1355	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	1	14	theme	treatment	274:282	arg1	plants					284:289	wastewater treatment plants	263:289	wastewater treatment plants	263:289	Anammox (anaerobic ammonium oxidation) bacteria are important for the nitrogen cycle in both natural environments and wastewater treatment plants.
32227885	5	15	theme	Quantification	731:744	arg1	assays					746:751	Quantification assays	731:751	Quantification assays	731:751	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	0	16	from	Acids	37:41	arg1	Substances					106:115	the Extracellular Polymeric Substances	78:115	the Extracellular Polymeric Substances of Anammox Granular Sludge	78:142	Decorating the Anammox House: Sialic Acids and Sulfated Glycosaminoglycans in the Extracellular Polymeric Substances of Anammox Granular Sludge.
32227885	5	17	theme	glycosaminoglycans	935:952	arg1	equivalents					911:921	2.4% equivalents	906:921	2.4% equivalents of sulfated glycosaminoglycans	906:952	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	5	17	theme	glycosaminoglycans	935:952	arg1	equivalents					874:884	1.6% equivalents	869:884	1.6% equivalents of sialic acids	869:900	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	6	18	theme	draft	1088:1092	arg1	genomes					1094:1100	the anammox draft genomes	1076:1100	the anammox draft genomes	1076:1100	Additionally, the potential genes for the biosynthesis of sialic acids and sulfated glycosaminoglycans were analyzed in the anammox draft genomes.
32227885	4	19	theme	granular	655:662	arg1	sludge					664:669	anammox granular sludge	647:669	anammox granular sludge	647:669	Here, we investigated anionic polymers in anammox granular sludge, focussing on sialic acids and sulfated glycosaminoglycans.
32227885	5	20	theme	sialic	791:796	arg1	acids					798:802	sialic acids	791:802	sialic acids	791:802	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	7	21	theme	nonpathogenic	1186:1198	arg1	bacteria					1200:1207	other nonpathogenic bacteria	1180:1207	other nonpathogenic bacteria	1180:1207	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	5	22	theme	1.6	869:871	arg1	%					872:872	%	872:872	%	872:872	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	5	23	theme	sulfated	808:815	arg1	glycosaminoglycans					817:834	sulfated glycosaminoglycans	808:834	sulfated glycosaminoglycans	808:834	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	7	24	from	finding	1107:1113	arg1	sludge					1155:1160	anammox granular sludge	1138:1160	anammox granular sludge	1138:1160	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	7	24	from	finding	1107:1113	arg1	bacteria					1200:1207	other nonpathogenic bacteria	1180:1207	other nonpathogenic bacteria	1180:1207	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	5	25	theme	sulfated	926:933	arg1	glycosaminoglycans					935:952	sulfated glycosaminoglycans	926:952	sulfated glycosaminoglycans	926:952	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	5	26	from	present	841:847	arg1	EPS					864:866	the anammox EPS	852:866	the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans)	852:953	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	3	27	theme	aggregates	426:435	arg1	formation					405:413	the formation	401:413	the formation of anammox aggregates	401:435	To understand the formation of anammox aggregates, it is required to unravel the composition of the extracellular polymeric substances (EPS), which are produced by the bacteria to develop into aggregates and granules.
32227885	7	28	theme	other	1180:1184	arg1	bacteria					1200:1207	other nonpathogenic bacteria	1180:1207	other nonpathogenic bacteria	1180:1207	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	6	29	theme	potential	974:982	arg1	genes					984:988	the potential genes	970:988	the potential genes for the biosynthesis of sialic acids and sulfated glycosaminoglycans	970:1057	Additionally, the potential genes for the biosynthesis of sialic acids and sulfated glycosaminoglycans were analyzed in the anammox draft genomes.
32227885	7	30	from	context	1302:1308	arg1	general					1380:1386	general	1380:1386	general	1380:1386	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	7	30	from	context	1302:1308	arg1	communities					1345:1355	microbial communities	1335:1355	microbial communities	1335:1355	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	2	31	theme	strong	314:319	arg1	tendency					321:328	a strong tendency	312:328	a strong tendency to grow in aggregates like biofilms and granular sludge	312:384	These bacteria have a strong tendency to grow in aggregates like biofilms and granular sludge.
32227885	4	32	theme	anammox	647:653	arg1	sludge					664:669	anammox granular sludge	647:669	anammox granular sludge	647:669	Here, we investigated anionic polymers in anammox granular sludge, focussing on sialic acids and sulfated glycosaminoglycans.
32227885	0	33	theme	Granular	128:135	arg1	Sludge					137:142	Anammox Granular Sludge	120:142	Anammox Granular Sludge	120:142	Decorating the Anammox House: Sialic Acids and Sulfated Glycosaminoglycans in the Extracellular Polymeric Substances of Anammox Granular Sludge.
32227885	6	34	theme	glycosaminoglycans	1040:1057	arg1	biosynthesis					998:1009	the biosynthesis	994:1009	the biosynthesis of sialic acids and sulfated glycosaminoglycans	994:1057	Additionally, the potential genes for the biosynthesis of sialic acids and sulfated glycosaminoglycans were analyzed in the anammox draft genomes.
32227885	7	35	theme	function	1323:1330	arg1	systems					1369:1375	biofilm systems	1361:1375	biofilm systems in general	1361:1386	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	7	35	theme	function	1323:1330	arg1	context					1302:1308	the context	1298:1308	the context of a broader function in microbial communities	1298:1355	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	0	36	theme	Anammox	15:21	arg1	House					23:27	the Anammox House	11:27	the Anammox House	11:27	Decorating the Anammox House: Sialic Acids and Sulfated Glycosaminoglycans in the Extracellular Polymeric Substances of Anammox Granular Sludge.
32227885	0	37	theme	Anammox	120:126	arg1	Sludge					137:142	Anammox Granular Sludge	120:142	Anammox Granular Sludge	120:142	Decorating the Anammox House: Sialic Acids and Sulfated Glycosaminoglycans in the Extracellular Polymeric Substances of Anammox Granular Sludge.
32227885	3	38	theme	substances	511:520	arg1	composition					468:478	the composition	464:478	the composition of the extracellular polymeric substances (EPS), which are produced by the bacteria to develop into aggregates and granules	464:602	To understand the formation of anammox aggregates, it is required to unravel the composition of the extracellular polymeric substances (EPS), which are produced by the bacteria to develop into aggregates and granules.
32227885	1	39	theme	Anammox	145:151	arg1	bacteria					184:191	Anammox (anaerobic ammonium oxidation) bacteria	145:191	Anammox (anaerobic ammonium oxidation) bacteria	145:191	Anammox (anaerobic ammonium oxidation) bacteria are important for the nitrogen cycle in both natural environments and wastewater treatment plants.
32227885	0	40	theme	Sialic	30:35	arg1	Acids					37:41	Sialic Acids	30:41	Sialic Acids	30:41	Decorating the Anammox House: Sialic Acids and Sulfated Glycosaminoglycans in the Extracellular Polymeric Substances of Anammox Granular Sludge.
32227885	4	41	theme	sialic	685:690	arg1	acids					692:696	sialic acids	685:696	sialic acids	685:696	Here, we investigated anionic polymers in anammox granular sludge, focussing on sialic acids and sulfated glycosaminoglycans.
32227885	5	42	theme	anammox	856:862	arg1	EPS					864:866	the anammox EPS	852:866	the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans)	852:953	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	7	43	theme	broader	1315:1321	arg1	function					1323:1330	a broader function	1313:1330	a broader function in microbial communities	1313:1355	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	4	44	theme	anionic	627:633	arg1	polymers					635:642	anionic polymers	627:642	anionic polymers	627:642	Here, we investigated anionic polymers in anammox granular sludge, focussing on sialic acids and sulfated glycosaminoglycans.
32227885	3	45	theme	anammox	418:424	arg1	aggregates					426:435	anammox aggregates	418:435	anammox aggregates	418:435	To understand the formation of anammox aggregates, it is required to unravel the composition of the extracellular polymeric substances (EPS), which are produced by the bacteria to develop into aggregates and granules.
32227885	2	46	contain	have	307:310	arg2	tendency					321:328	a strong tendency	312:328	a strong tendency to grow in aggregates like biofilms and granular sludge	312:384	These bacteria have a strong tendency to grow in aggregates like biofilms and granular sludge.
32227885	2	46	contain	have	307:310	arg1	bacteria					298:305	These bacteria	292:305	These bacteria	292:305	These bacteria have a strong tendency to grow in aggregates like biofilms and granular sludge.
32227885	0	47	theme	Sludge	137:142	arg1	Substances					106:115	the Extracellular Polymeric Substances	78:115	the Extracellular Polymeric Substances of Anammox Granular Sludge	78:142	Decorating the Anammox House: Sialic Acids and Sulfated Glycosaminoglycans in the Extracellular Polymeric Substances of Anammox Granular Sludge.
32227885	0	48	from	Glycosaminoglycans	56:73	arg1	Substances					106:115	the Extracellular Polymeric Substances	78:115	the Extracellular Polymeric Substances of Anammox Granular Sludge	78:142	Decorating the Anammox House: Sialic Acids and Sulfated Glycosaminoglycans in the Extracellular Polymeric Substances of Anammox Granular Sludge.
32227885	1	49	theme	nitrogen	215:222	arg1	cycle					224:228	the nitrogen cycle	211:228	the nitrogen cycle in both natural environments and wastewater treatment plants	211:289	Anammox (anaerobic ammonium oxidation) bacteria are important for the nitrogen cycle in both natural environments and wastewater treatment plants.
32227885	7	50	theme	anammox	1138:1144	arg1	sludge					1155:1160	anammox granular sludge	1138:1160	anammox granular sludge	1138:1160	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	5	51	theme	%	872:872	arg1	equivalents					874:884	1.6% equivalents	869:884	1.6% equivalents of sialic acids	869:900	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	5	52	theme	fluorescent	757:767	arg1	stains					769:774	fluorescent stains	757:774	fluorescent stains	757:774	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	5	53	from	EPS	864:866	arg1	present					841:847	present	841:847	present	841:847	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	5	54	theme	2.4	906:908	arg1	%					909:909	%	909:909	%	909:909	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	7	55	theme	granular	1146:1153	arg1	sludge					1155:1160	anammox granular sludge	1138:1160	anammox granular sludge	1138:1160	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	7	56	dep	pointed	1209:1215	arg1	out					1217:1219	out	1217:1219	out	1217:1219	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	7	57	theme	biofilm	1361:1367	arg1	systems					1369:1375	biofilm systems	1361:1375	biofilm systems in general	1361:1386	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	3	58	theme	extracellular	487:499	arg1	substances					511:520	the extracellular polymeric substances	483:520	the extracellular polymeric substances (EPS)	483:526	To understand the formation of anammox aggregates, it is required to unravel the composition of the extracellular polymeric substances (EPS), which are produced by the bacteria to develop into aggregates and granules.
32227885	3	58	theme	extracellular	487:499	arg1	EPS					523:525	EPS	523:525	EPS	523:525	To understand the formation of anammox aggregates, it is required to unravel the composition of the extracellular polymeric substances (EPS), which are produced by the bacteria to develop into aggregates and granules.
32227885	1	59	from	cycle	224:228	arg1	plants					284:289	wastewater treatment plants	263:289	wastewater treatment plants	263:289	Anammox (anaerobic ammonium oxidation) bacteria are important for the nitrogen cycle in both natural environments and wastewater treatment plants.
32227885	1	59	from	cycle	224:228	arg1	environments					246:257	natural environments	238:257	natural environments	238:257	Anammox (anaerobic ammonium oxidation) bacteria are important for the nitrogen cycle in both natural environments and wastewater treatment plants.
32227885	4	60	theme	sulfated	702:709	arg1	glycosaminoglycans					711:728	sulfated glycosaminoglycans	702:728	sulfated glycosaminoglycans	702:728	Here, we investigated anionic polymers in anammox granular sludge, focussing on sialic acids and sulfated glycosaminoglycans.
32227885	5	61	dep	EPS	864:866	arg1	equivalents					911:921	2.4% equivalents	906:921	2.4% equivalents of sulfated glycosaminoglycans	906:952	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	5	61	dep	EPS	864:866	arg1	equivalents					874:884	1.6% equivalents	869:884	1.6% equivalents of sialic acids	869:900	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	7	62	theme	microbial	1335:1343	arg1	communities					1345:1355	microbial communities	1335:1355	microbial communities	1335:1355	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	6	63	theme	acids	1021:1025	arg1	biosynthesis					998:1009	the biosynthesis	994:1009	the biosynthesis of sialic acids and sulfated glycosaminoglycans	994:1057	Additionally, the potential genes for the biosynthesis of sialic acids and sulfated glycosaminoglycans were analyzed in the anammox draft genomes.
32227885	7	64	theme	sulfated	1243:1250	arg1	glycosaminoglycans					1252:1269	sulfated glycosaminoglycans	1243:1269	sulfated glycosaminoglycans	1243:1269	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	6	65	theme	sulfated	1031:1038	arg1	glycosaminoglycans					1040:1057	sulfated glycosaminoglycans	1031:1057	sulfated glycosaminoglycans	1031:1057	Additionally, the potential genes for the biosynthesis of sialic acids and sulfated glycosaminoglycans were analyzed in the anammox draft genomes.
32227885	7	66	from	communities	1345:1355	arg1	systems					1369:1375	biofilm systems	1361:1375	biofilm systems in general	1361:1386	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	7	66	from	communities	1345:1355	arg1	context					1302:1308	the context	1298:1308	the context of a broader function in microbial communities	1298:1355	The finding of these components in anammox granular sludge and previously in other nonpathogenic bacteria pointed out that sialic acids and sulfated glycosaminoglycans are worth investigating in the context of a broader function in microbial communities and biofilm systems in general.
32227885	2	67	theme	granular	370:377	arg1	sludge					379:384	granular sludge	370:384	granular sludge	370:384	These bacteria have a strong tendency to grow in aggregates like biofilms and granular sludge.
32227885	6	68	theme	anammox	1080:1086	arg1	genomes					1094:1100	the anammox draft genomes	1076:1100	the anammox draft genomes	1076:1100	Additionally, the potential genes for the biosynthesis of sialic acids and sulfated glycosaminoglycans were analyzed in the anammox draft genomes.
32227885	6	69	theme	sialic	1014:1019	arg1	acids					1021:1025	sialic acids	1014:1025	sialic acids	1014:1025	Additionally, the potential genes for the biosynthesis of sialic acids and sulfated glycosaminoglycans were analyzed in the anammox draft genomes.
32227885	0	70	theme	Sulfated	47:54	arg1	Glycosaminoglycans					56:73	Sulfated Glycosaminoglycans	47:73	Sulfated Glycosaminoglycans	47:73	Decorating the Anammox House: Sialic Acids and Sulfated Glycosaminoglycans in the Extracellular Polymeric Substances of Anammox Granular Sludge.
32227885	0	71	dep	Decorating	0:9	arg1	Acids					37:41	Sialic Acids	30:41	Sialic Acids	30:41	Decorating the Anammox House: Sialic Acids and Sulfated Glycosaminoglycans in the Extracellular Polymeric Substances of Anammox Granular Sludge.
32227885	0	71	dep	Decorating	0:9	arg1	Glycosaminoglycans					56:73	Sulfated Glycosaminoglycans	47:73	Sulfated Glycosaminoglycans	47:73	Decorating the Anammox House: Sialic Acids and Sulfated Glycosaminoglycans in the Extracellular Polymeric Substances of Anammox Granular Sludge.
32227885	5	72	theme	sialic	889:894	arg1	acids					896:900	sialic acids	889:900	sialic acids	889:900	Quantification assays and fluorescent stains indicated that sialic acids and sulfated glycosaminoglycans were present in the anammox EPS (1.6% equivalents of sialic acids and 2.4% equivalents of sulfated glycosaminoglycans).
32227885	1	73	theme	natural	238:244	arg1	environments					246:257	natural environments	238:257	natural environments	238:257	Anammox (anaerobic ammonium oxidation) bacteria are important for the nitrogen cycle in both natural environments and wastewater treatment plants.
34022546	4	0	theme	Primer	591:596	arg1	application					554:564	application	554:564	: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	549:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	0	theme	Primer	591:596	arg1	groups					538:543	The experimental groups	521:543	The experimental groups	521:543	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	12	1	theme	present	1851:1857	arg1	MMPs					1846:1849	MMPs	1846:1849	MMPs present in dentin	1846:1867	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	6	2	with	primer	878:883	arg1	nanoparticles					899:911	cationic nanoparticles	890:911	cationic nanoparticles	890:911	The effect of experimental primer with cationic nanoparticles in the inhibition of matrix metalloproteinase (MMP) activity was carrying out by in situ zymography.
34022546	12	3	dep	CONCLUSION	1704:1713	arg1	alter					1800:1804	alter	1800:1804	does not alter the adhesive resistance	1791:1828	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	12	3	dep	CONCLUSION	1704:1713	arg1	has					1763:1765	has	1763:1765	has antimicrobial activity	1763:1788	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	12	3	dep	CONCLUSION	1704:1713	arg1	inactivates					1834:1844	inactivates	1834:1844	inactivates MMPs present in dentin	1834:1867	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	5	4	used	used	774:777	arg2	plateau					762:768	A composite resin plateau	744:768	A composite resin plateau	744:768	A composite resin plateau was used for the analysis, where sections were made for making the dentin beams.
34022546	1	5	theme	cationic	290:297	arg1	NPL-chitosan					320:331	NPL-chitosan	320:331	NPL-chitosan	320:331	OBJECTIVE The aim of this study was to synthesize and characterize an experimental primer containing cationic lipid nanoparticles (NPL-chitosan) and to evaluate its properties.
34022546	1	5	theme	cationic	290:297	arg1	nanoparticles					305:317	cationic lipid nanoparticles	290:317	cationic lipid nanoparticles (NPL-chitosan)	290:332	OBJECTIVE The aim of this study was to synthesize and characterize an experimental primer containing cationic lipid nanoparticles (NPL-chitosan) and to evaluate its properties.
34022546	4	6	theme	2	651:651	arg1	%					652:652	%	652:652	%	652:652	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	11	7	theme	MMPs	1658:1661	arg1	activity					1646:1653	higher inactivation activity	1626:1653	higher inactivation activity of MMPs	1626:1661	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34022546	12	8	attach	present	1851:1857	arg2	MMPs					1846:1849	MMPs	1846:1849	MMPs present in dentin	1846:1867	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	12	8	attach	present	1851:1857	arg1	dentin					1862:1867	dentin	1862:1867	dentin	1862:1867	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	0	9	theme	metalloproteinases	123:140	arg1	inactivation					107:118	the inactivation	103:118	the inactivation of metalloproteinases	103:140	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	1	10	theme	study	215:219	arg1	aim					203:205	The aim	199:205	The aim of this study	199:219	OBJECTIVE The aim of this study was to synthesize and characterize an experimental primer containing cationic lipid nanoparticles (NPL-chitosan) and to evaluate its properties.
34022546	6	11	theme	experimental	865:876	arg1	primer					878:883	experimental primer	865:883	experimental primer with cationic nanoparticles	865:911	The effect of experimental primer with cationic nanoparticles in the inhibition of matrix metalloproteinase (MMP) activity was carrying out by in situ zymography.
34022546	11	12	theme	other	1679:1683	arg1	<					1695:1695	p < 0.05	1693:1700	p < 0.05	1693:1700	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34022546	11	12	theme	other	1679:1683	arg1	groups					1685:1690	the other groups	1675:1690	the other groups (p < 0.05)	1675:1701	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34022546	0	13	theme	antimicrobial	143:155	arg1	activity					157:164	antimicrobial activity	143:164	antimicrobial activity	143:164	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	4	14	dep	Primer	591:596	arg1	2					588:588	2	588:588	2	588:588	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	15	theme	Primer	671:676	arg1	NPL-chitosan					692:703	NPL-chitosan 5)	692:706	NPL-chitosan 5)	692:706	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	15	theme	Primer	671:676	arg1	%					687:687	Primer with 0.6 %	671:687	2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	609:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	6	16	dep	in	994:995	arg1	situ					997:1000	situ	997:1000	situ	997:1000	The effect of experimental primer with cationic nanoparticles in the inhibition of matrix metalloproteinase (MMP) activity was carrying out by in situ zymography.
34022546	1	17	contain	containing	279:288	arg1	primer					272:277	an experimental primer	256:277	an experimental primer containing cationic lipid nanoparticles (NPL-chitosan)	256:332	OBJECTIVE The aim of this study was to synthesize and characterize an experimental primer containing cationic lipid nanoparticles (NPL-chitosan) and to evaluate its properties.
34022546	1	17	contain	containing	279:288	arg2	NPL-chitosan					320:331	NPL-chitosan	320:331	NPL-chitosan	320:331	OBJECTIVE The aim of this study was to synthesize and characterize an experimental primer containing cationic lipid nanoparticles (NPL-chitosan) and to evaluate its properties.
34022546	1	17	contain	containing	279:288	arg2	nanoparticles					305:317	cationic lipid nanoparticles	290:317	cationic lipid nanoparticles (NPL-chitosan)	290:332	OBJECTIVE The aim of this study was to synthesize and characterize an experimental primer containing cationic lipid nanoparticles (NPL-chitosan) and to evaluate its properties.
34022546	6	18	theme	metalloproteinase	941:957	arg1	activity					965:972	matrix metalloproteinase (MMP) activity	934:972	matrix metalloproteinase (MMP) activity	934:972	The effect of experimental primer with cationic nanoparticles in the inhibition of matrix metalloproteinase (MMP) activity was carrying out by in situ zymography.
34022546	0	19	theme	chitosan	68:75	arg1	nanoparticles					77:89	chitosan nanoparticles	68:89	chitosan nanoparticles	68:89	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	4	20	theme	experimental	525:536	arg1	application					554:564	application	554:564	: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	549:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	20	theme	experimental	525:536	arg1	groups					538:543	The experimental groups	521:543	The experimental groups	521:543	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	11	21	theme	higher	1626:1631	arg1	activity					1646:1653	higher inactivation activity	1626:1653	higher inactivation activity of MMPs	1626:1661	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34022546	11	22	theme	NPL-chitosan	1603:1614	arg1	%					1598:1598	2%	1597:1598	2% of NPL-chitosan	1597:1614	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34022546	11	22	theme	NPL-chitosan	1603:1614	arg1	NPL-chitosan					1603:1614	NPL-chitosan	1603:1614	NPL-chitosan	1603:1614	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34022546	9	23	theme	%	1423:1423	arg1	MIC					1390:1392	MIC	1390:1392	MIC of the 0.4 %	1390:1405	These nanoparticles showed antibacterial activity agsainst S. mutans with MIC of the 0.4 % and MBC of 0.67 %.
34022546	9	23	theme	%	1423:1423	arg1	MBC					1411:1413	MBC	1411:1413	MBC of 0.67 %	1411:1423	These nanoparticles showed antibacterial activity agsainst S. mutans with MIC of the 0.4 % and MBC of 0.67 %.
34022546	4	24	theme	with	716:719	arg1	NPL-chitosan					730:741	NPL-chitosan	730:741	NPL-chitosan	730:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	24	theme	with	716:719	arg1	%					725:725	Primer with 0.4 %	709:725	2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	609:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	10	25	theme	=	1530:1530	arg1	p					1528:1528	p = 0.9054	1528:1537	p = 0.9054	1528:1537	In the Microtensile Strength, no statistical difference was observed between the experimental groups (p = 0.9054).
34022546	10	25	theme	=	1530:1530	arg1	groups					1520:1525	the experimental groups	1503:1525	the experimental groups (p = 0.9054)	1503:1538	In the Microtensile Strength, no statistical difference was observed between the experimental groups (p = 0.9054).
34022546	7	26	theme	One-way	1099:1105	arg1	analysis					1107:1114	the One-way analysis	1095:1114	the One-way analysis of variance (ANOVA)	1095:1134	For the Resin-Dentin Adhesive Strength and in situ Zymography analysis, was used the One-way analysis of variance (ANOVA) with significance level of 95 %.
34022546	12	27	theme	experimental	1719:1730	arg1	NPL-chitosan					1750:1761	The experimental primer containing NPL-chitosan	1715:1761	The experimental primer containing NPL-chitosan	1715:1761	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	8	28	theme	zeta	1263:1266	arg1	potential					1268:1276	zeta potential positive	1263:1285	zeta potential positive	1263:1285	RESULTS Spherical NPL-chitosan presented size below 220 nm, polydispersity index of 0.179 and zeta potential positive and was stable over 75 days.
34022546	2	29	theme	emulsion	410:417	arg1	method					434:439	emulsion and sonication method	410:439	emulsion and sonication method	410:439	DESIGN The NPL-chitosan were synthesized by emulsion and sonication method.
34022546	1	30	theme	lipid	299:303	arg1	NPL-chitosan					320:331	NPL-chitosan	320:331	NPL-chitosan	320:331	OBJECTIVE The aim of this study was to synthesize and characterize an experimental primer containing cationic lipid nanoparticles (NPL-chitosan) and to evaluate its properties.
34022546	1	30	theme	lipid	299:303	arg1	nanoparticles					305:317	cationic lipid nanoparticles	290:317	cationic lipid nanoparticles (NPL-chitosan)	290:332	OBJECTIVE The aim of this study was to synthesize and characterize an experimental primer containing cationic lipid nanoparticles (NPL-chitosan) and to evaluate its properties.
34022546	12	31	theme	containing	1739:1748	arg1	NPL-chitosan					1750:1761	The experimental primer containing NPL-chitosan	1715:1761	The experimental primer containing NPL-chitosan	1715:1761	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	4	32	theme	commercial	569:578	arg1	Primer					591:596	commercial primer; 2) Primer	569:596	commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	569:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	2	33	dep	DESIGN	366:371	arg1	NPL-chitosan					377:388	The NPL-chitosan	373:388	DESIGN The NPL-chitosan	366:388	DESIGN The NPL-chitosan were synthesized by emulsion and sonication method.
34022546	5	34	theme	resin	756:760	arg1	plateau					762:768	A composite resin plateau	744:768	A composite resin plateau	744:768	A composite resin plateau was used for the analysis, where sections were made for making the dentin beams.
34022546	6	35	theme	activity	965:972	arg1	inhibition					920:929	the inhibition	916:929	the inhibition of matrix metalloproteinase (MMP) activity	916:972	The effect of experimental primer with cationic nanoparticles in the inhibition of matrix metalloproteinase (MMP) activity was carrying out by in situ zymography.
34022546	12	36	contain	has	1763:1765	arg1	NPL-chitosan					1750:1761	The experimental primer containing NPL-chitosan	1715:1761	The experimental primer containing NPL-chitosan	1715:1761	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	12	36	contain	has	1763:1765	arg2	activity					1781:1788	antimicrobial activity	1767:1788	antimicrobial activity	1767:1788	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	3	37	theme	dentin	483:488	arg1	surface					490:496	dentin surface	483:496	dentin surface of fifty human molars	483:518	The experimental primers were applied in dentin surface of fifty human molars.
34022546	7	38	theme	Zymography	1065:1074	arg1	analysis					1076:1083	in situ Zymography analysis	1057:1083	in situ Zymography analysis	1057:1083	For the Resin-Dentin Adhesive Strength and in situ Zymography analysis, was used the One-way analysis of variance (ANOVA) with significance level of 95 %.
34022546	3	39	theme	experimental	446:457	arg1	primers					459:465	The experimental primers	442:465	The experimental primers	442:465	The experimental primers were applied in dentin surface of fifty human molars.
34022546	10	40	located	observed	1486:1493	arg1	Strength					1446:1453	the Microtensile Strength	1429:1453	the Microtensile Strength	1429:1453	In the Microtensile Strength, no statistical difference was observed between the experimental groups (p = 0.9054).
34022546	10	40	located	observed	1486:1493	arg2	difference					1471:1480	no statistical difference	1456:1480	no statistical difference	1456:1480	In the Microtensile Strength, no statistical difference was observed between the experimental groups (p = 0.9054).
34022546	0	41	theme	primer	50:55	arg1	characterization					14:29	characterization	14:29	characterization	14:29	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	0	41	theme	primer	50:55	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	11	42	theme	in	1545:1546	arg1	assay					1564:1568	The in situ zymography assay	1541:1568	The in situ zymography assay	1541:1568	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34022546	3	43	theme	human	507:511	arg1	molars					513:518	fifty human molars	501:518	fifty human molars	501:518	The experimental primers were applied in dentin surface of fifty human molars.
34022546	11	44	dep	in	1545:1546	arg1	situ					1548:1551	situ	1548:1551	situ	1548:1551	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34022546	7	45	theme	%	1166:1166	arg1	level					1154:1158	significance level	1141:1158	significance level of 95 %	1141:1166	For the Resin-Dentin Adhesive Strength and in situ Zymography analysis, was used the One-way analysis of variance (ANOVA) with significance level of 95 %.
34022546	8	46	theme	positive	1278:1285	arg1	potential					1268:1276	zeta potential positive	1263:1285	zeta potential positive	1263:1285	RESULTS Spherical NPL-chitosan presented size below 220 nm, polydispersity index of 0.179 and zeta potential positive and was stable over 75 days.
34022546	9	47	dep	agsainst	1366:1373	arg1	mutans					1378:1383	S. mutans	1375:1383	S. mutans	1375:1383	These nanoparticles showed antibacterial activity agsainst S. mutans with MIC of the 0.4 % and MBC of 0.67 %.
34022546	0	48	dep	Synthesis	0:8	arg1	activity					157:164	antimicrobial activity	143:164	antimicrobial activity	143:164	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	0	48	dep	Synthesis	0:8	arg1	strength					179:186	adhesive strength	170:186	adhesive strength	170:186	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	0	48	dep	Synthesis	0:8	arg1	Effect					93:98	Effect	93:98	Effect on the inactivation of metalloproteinases	93:140	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	4	49	theme	Chlorhexidine	615:627	arg1	CHX					630:632	Chlorhexidine (CHX) 3)	615:636	Chlorhexidine (CHX) 3)	615:636	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	7	50	theme	Adhesive	1035:1042	arg1	Strength					1044:1051	Adhesive Strength	1035:1051	Adhesive Strength	1035:1051	For the Resin-Dentin Adhesive Strength and in situ Zymography analysis, was used the One-way analysis of variance (ANOVA) with significance level of 95 %.
34022546	1	51	theme	experimental	259:270	arg1	primer					272:277	an experimental primer	256:277	an experimental primer containing cationic lipid nanoparticles (NPL-chitosan)	256:332	OBJECTIVE The aim of this study was to synthesize and characterize an experimental primer containing cationic lipid nanoparticles (NPL-chitosan) and to evaluate its properties.
34022546	7	52	theme	significance	1141:1152	arg1	level					1154:1158	significance level	1141:1158	significance level of 95 %	1141:1166	For the Resin-Dentin Adhesive Strength and in situ Zymography analysis, was used the One-way analysis of variance (ANOVA) with significance level of 95 %.
34022546	0	53	from	strength	179:186	arg1	inactivation					107:118	the inactivation	103:118	the inactivation of metalloproteinases	103:140	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	0	54	contain	containing	57:66	arg1	primer					50:55	an experimental primer	34:55	an experimental primer containing chitosan nanoparticles	34:89	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	0	54	contain	containing	57:66	arg2	nanoparticles					77:89	chitosan nanoparticles	68:89	chitosan nanoparticles	68:89	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	12	55	from	dentin	1862:1867	arg1	present					1851:1857	present	1851:1857	present	1851:1857	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	10	56	theme	Microtensile	1433:1444	arg1	Strength					1446:1453	the Microtensile Strength	1429:1453	the Microtensile Strength	1429:1453	In the Microtensile Strength, no statistical difference was observed between the experimental groups (p = 0.9054).
34022546	7	57	theme	in	1057:1058	arg1	analysis					1076:1083	in situ Zymography analysis	1057:1083	in situ Zymography analysis	1057:1083	For the Resin-Dentin Adhesive Strength and in situ Zymography analysis, was used the One-way analysis of variance (ANOVA) with significance level of 95 %.
34022546	12	58	from	present	1851:1857	arg1	dentin					1862:1867	dentin	1862:1867	dentin	1862:1867	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	11	59	with	group	1586:1590	arg1	%					1598:1598	2%	1597:1598	2% of NPL-chitosan	1597:1614	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34022546	11	59	with	group	1586:1590	arg1	NPL-chitosan					1603:1614	NPL-chitosan	1603:1614	NPL-chitosan	1603:1614	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34022546	9	60	theme	antibacterial	1343:1355	arg1	activity					1357:1364	antibacterial activity	1343:1364	antibacterial activity agsainst S. mutans	1343:1383	These nanoparticles showed antibacterial activity agsainst S. mutans with MIC of the 0.4 % and MBC of 0.67 %.
34022546	12	61	theme	adhesive	1810:1817	arg1	resistance					1819:1828	the adhesive resistance	1806:1828	the adhesive resistance	1806:1828	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	6	62	theme	cationic	890:897	arg1	nanoparticles					899:911	cationic nanoparticles	890:911	cationic nanoparticles	890:911	The effect of experimental primer with cationic nanoparticles in the inhibition of matrix metalloproteinase (MMP) activity was carrying out by in situ zymography.
34022546	10	63	theme	statistical	1459:1469	arg1	difference					1471:1480	no statistical difference	1456:1480	no statistical difference	1456:1480	In the Microtensile Strength, no statistical difference was observed between the experimental groups (p = 0.9054).
34022546	9	64	theme	agsainst	1366:1373	arg1	activity					1357:1364	antibacterial activity	1343:1364	antibacterial activity agsainst S. mutans	1343:1383	These nanoparticles showed antibacterial activity agsainst S. mutans with MIC of the 0.4 % and MBC of 0.67 %.
34022546	6	65	theme	primer	878:883	arg1	effect					855:860	The effect	851:860	The effect of experimental primer with cationic nanoparticles in the inhibition of matrix metalloproteinase (MMP) activity	851:972	The effect of experimental primer with cationic nanoparticles in the inhibition of matrix metalloproteinase (MMP) activity was carrying out by in situ zymography.
34022546	0	66	from	Effect	93:98	arg1	inactivation					107:118	the inactivation	103:118	the inactivation of metalloproteinases	103:140	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	4	67	theme	CHX	630:632	arg1	CHX					630:632	Chlorhexidine (CHX) 3)	615:636	Chlorhexidine (CHX) 3)	615:636	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	67	theme	CHX	630:632	arg1	%					610:610	2%	609:610	2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	609:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	10	68	theme	experimental	1507:1518	arg1	p					1528:1528	p = 0.9054	1528:1537	p = 0.9054	1528:1537	In the Microtensile Strength, no statistical difference was observed between the experimental groups (p = 0.9054).
34022546	10	68	theme	experimental	1507:1518	arg1	groups					1520:1525	the experimental groups	1503:1525	the experimental groups (p = 0.9054)	1503:1538	In the Microtensile Strength, no statistical difference was observed between the experimental groups (p = 0.9054).
34022546	4	69	contain	containing	598:607	arg2	CHX					630:632	Chlorhexidine (CHX) 3)	615:636	Chlorhexidine (CHX) 3)	615:636	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	69	contain	containing	598:607	arg1	Primer					591:596	commercial primer; 2) Primer	569:596	commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	569:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	69	contain	containing	598:607	arg2	%					610:610	2%	609:610	2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	609:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	0	70	theme	adhesive	170:177	arg1	strength					179:186	adhesive strength	170:186	adhesive strength	170:186	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	8	71	theme	Spherical	1177:1185	arg1	NPL-chitosan					1187:1198	Spherical NPL-chitosan	1177:1198	Spherical NPL-chitosan	1177:1198	RESULTS Spherical NPL-chitosan presented size below 220 nm, polydispersity index of 0.179 and zeta potential positive and was stable over 75 days.
34022546	5	72	theme	dentin	837:842	arg1	beams					844:848	the dentin beams	833:848	the dentin beams	833:848	A composite resin plateau was used for the analysis, where sections were made for making the dentin beams.
34022546	4	73	theme	with	678:681	arg1	NPL-chitosan					692:703	NPL-chitosan 5)	692:706	NPL-chitosan 5)	692:706	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	73	theme	with	678:681	arg1	%					687:687	Primer with 0.6 %	671:687	2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	609:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	74	dep	%	610:610	arg1	NPL-chitosan					692:703	NPL-chitosan 5)	692:706	NPL-chitosan 5)	692:706	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	74	dep	%	610:610	arg1	Primer					639:644	Primer	639:644	2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	609:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	74	dep	%	610:610	arg1	%					687:687	Primer with 0.6 %	671:687	2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	609:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	74	dep	%	610:610	arg1	NPL-chitosan					730:741	NPL-chitosan	730:741	NPL-chitosan	730:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	74	dep	%	610:610	arg1	%					725:725	Primer with 0.4 %	709:725	2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	609:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	9	75	theme	%	1405:1405	arg1	MIC					1390:1392	MIC	1390:1392	MIC of the 0.4 %	1390:1405	These nanoparticles showed antibacterial activity agsainst S. mutans with MIC of the 0.4 % and MBC of 0.67 %.
34022546	9	75	theme	%	1405:1405	arg1	MBC					1411:1413	MBC	1411:1413	MBC of 0.67 %	1411:1423	These nanoparticles showed antibacterial activity agsainst S. mutans with MIC of the 0.4 % and MBC of 0.67 %.
34022546	6	76	theme	matrix	934:939	arg1	MMP					960:962	MMP	960:962	MMP	960:962	The effect of experimental primer with cationic nanoparticles in the inhibition of matrix metalloproteinase (MMP) activity was carrying out by in situ zymography.
34022546	6	76	theme	matrix	934:939	arg1	metalloproteinase					941:957	matrix metalloproteinase	934:957	matrix metalloproteinase (MMP) activity	934:972	The effect of experimental primer with cationic nanoparticles in the inhibition of matrix metalloproteinase (MMP) activity was carrying out by in situ zymography.
34022546	4	77	theme	%	652:652	arg1	NPL-chitosan					654:665	2% NPL-chitosan	651:665	2% NPL-chitosan 4)	651:668	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	7	78	theme	variance	1119:1126	arg1	analysis					1107:1114	the One-way analysis	1095:1114	the One-way analysis of variance (ANOVA)	1095:1134	For the Resin-Dentin Adhesive Strength and in situ Zymography analysis, was used the One-way analysis of variance (ANOVA) with significance level of 95 %.
34022546	4	79	dep	application	554:564	arg1	1					551:551	1	551:551	1	551:551	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	12	80	theme	antimicrobial	1767:1779	arg1	activity					1781:1788	antimicrobial activity	1767:1788	antimicrobial activity	1767:1788	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	11	81	theme	inactivation	1633:1644	arg1	activity					1646:1653	higher inactivation activity	1626:1653	higher inactivation activity of MMPs	1626:1661	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34022546	8	82	dep	RESULTS	1169:1175	arg1	presented					1200:1208	presented	1200:1208	presented size below 220 nm, polydispersity index of 0.179 and zeta potential positive	1200:1285	RESULTS Spherical NPL-chitosan presented size below 220 nm, polydispersity index of 0.179 and zeta potential positive and was stable over 75 days.
34022546	8	82	dep	RESULTS	1169:1175	arg1	stable					1295:1300	stable	1295:1300	stable	1295:1300	RESULTS Spherical NPL-chitosan presented size below 220 nm, polydispersity index of 0.179 and zeta potential positive and was stable over 75 days.
34022546	8	83	theme	polydispersity	1229:1242	arg1	index					1244:1248	polydispersity index	1229:1248	polydispersity index of 0.179	1229:1257	RESULTS Spherical NPL-chitosan presented size below 220 nm, polydispersity index of 0.179 and zeta potential positive and was stable over 75 days.
34022546	3	84	theme	molars	513:518	arg1	surface					490:496	dentin surface	483:496	dentin surface of fifty human molars	483:518	The experimental primers were applied in dentin surface of fifty human molars.
34022546	12	85	theme	primer	1732:1737	arg1	NPL-chitosan					1750:1761	The experimental primer containing NPL-chitosan	1715:1761	The experimental primer containing NPL-chitosan	1715:1761	CONCLUSION The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
34022546	6	86	theme	in	994:995	arg1	zymography					1002:1011	in situ zymography	994:1011	in situ zymography	994:1011	The effect of experimental primer with cationic nanoparticles in the inhibition of matrix metalloproteinase (MMP) activity was carrying out by in situ zymography.
34022546	7	87	dep	in	1057:1058	arg1	situ					1060:1063	situ	1060:1063	situ	1060:1063	For the Resin-Dentin Adhesive Strength and in situ Zymography analysis, was used the One-way analysis of variance (ANOVA) with significance level of 95 %.
34022546	4	88	theme	Primer	709:714	arg1	NPL-chitosan					730:741	NPL-chitosan	730:741	NPL-chitosan	730:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	88	theme	Primer	709:714	arg1	%					725:725	Primer with 0.4 %	709:725	2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	609:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	1	89	dep	OBJECTIVE	189:197	arg1	was					221:223	was	221:223	was to synthesize and characterize an experimental primer containing cationic lipid nanoparticles (NPL-chitosan) and to evaluate its properties	221:363	OBJECTIVE The aim of this study was to synthesize and characterize an experimental primer containing cationic lipid nanoparticles (NPL-chitosan) and to evaluate its properties.
34022546	4	90	theme	primer	580:585	arg1	Primer					591:596	commercial primer; 2) Primer	569:596	commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	569:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	5	91	theme	composite	746:754	arg1	plateau					762:768	A composite resin plateau	744:768	A composite resin plateau	744:768	A composite resin plateau was used for the analysis, where sections were made for making the dentin beams.
34022546	4	92	theme	NPL-chitosan	730:741	arg1	NPL-chitosan					730:741	NPL-chitosan	730:741	NPL-chitosan	730:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	92	theme	NPL-chitosan	730:741	arg1	%					725:725	Primer with 0.4 %	709:725	2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	609:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	8	93	theme	0.179	1253:1257	arg1	potential					1268:1276	zeta potential positive	1263:1285	zeta potential positive	1263:1285	RESULTS Spherical NPL-chitosan presented size below 220 nm, polydispersity index of 0.179 and zeta potential positive and was stable over 75 days.
34022546	8	93	theme	0.179	1253:1257	arg1	nm					1225:1226	220 nm	1221:1226	220 nm	1221:1226	RESULTS Spherical NPL-chitosan presented size below 220 nm, polydispersity index of 0.179 and zeta potential positive and was stable over 75 days.
34022546	8	93	theme	0.179	1253:1257	arg1	index					1244:1248	polydispersity index	1229:1248	polydispersity index of 0.179	1229:1257	RESULTS Spherical NPL-chitosan presented size below 220 nm, polydispersity index of 0.179 and zeta potential positive and was stable over 75 days.
34022546	11	94	theme	zymography	1553:1562	arg1	assay					1564:1568	The in situ zymography assay	1541:1568	The in situ zymography assay	1541:1568	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34022546	4	95	theme	NPL-chitosan	692:703	arg1	NPL-chitosan					692:703	NPL-chitosan 5)	692:706	NPL-chitosan 5)	692:706	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	4	95	theme	NPL-chitosan	692:703	arg1	%					687:687	Primer with 0.6 %	671:687	2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan	609:741	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	0	96	theme	experimental	37:48	arg1	primer					50:55	an experimental primer	34:55	an experimental primer containing chitosan nanoparticles	34:89	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	7	97	used	used	1090:1093	arg2	Strength					1044:1051	Adhesive Strength	1035:1051	Adhesive Strength	1035:1051	For the Resin-Dentin Adhesive Strength and in situ Zymography analysis, was used the One-way analysis of variance (ANOVA) with significance level of 95 %.
34022546	7	97	used	used	1090:1093	arg2	analysis					1076:1083	in situ Zymography analysis	1057:1083	in situ Zymography analysis	1057:1083	For the Resin-Dentin Adhesive Strength and in situ Zymography analysis, was used the One-way analysis of variance (ANOVA) with significance level of 95 %.
34022546	2	98	theme	sonication	423:432	arg1	method					434:439	emulsion and sonication method	410:439	emulsion and sonication method	410:439	DESIGN The NPL-chitosan were synthesized by emulsion and sonication method.
34022546	4	99	with	Primer	639:644	arg1	NPL-chitosan					654:665	2% NPL-chitosan	651:665	2% NPL-chitosan 4)	651:668	The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan.
34022546	0	100	from	activity	157:164	arg1	inactivation					107:118	the inactivation	103:118	the inactivation of metalloproteinases	103:140	Synthesis and characterization of an experimental primer containing chitosan nanoparticles - Effect on the inactivation of metalloproteinases, antimicrobial activity and adhesive strength.
34022546	6	101	from	effect	855:860	arg1	inhibition					920:929	the inhibition	916:929	the inhibition of matrix metalloproteinase (MMP) activity	916:972	The effect of experimental primer with cationic nanoparticles in the inhibition of matrix metalloproteinase (MMP) activity was carrying out by in situ zymography.
34022546	11	102	theme	p	1693:1693	arg1	<					1695:1695	p < 0.05	1693:1700	p < 0.05	1693:1700	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34022546	11	102	theme	p	1693:1693	arg1	groups					1685:1690	the other groups	1675:1690	the other groups (p < 0.05)	1675:1701	The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
34652130	6	0	theme	coli	1030:1033	arg1	biofilms					1035:1042	E. coli biofilms	1027:1042	E. coli biofilms	1027:1042	Cellulose and curli are the major extracellular-matrix components in E. coli biofilms.
34652130	10	1	theme	biofilm	1691:1697	arg1	phenotypes					1710:1719	biofilm resistance phenotypes	1691:1719	biofilm resistance phenotypes	1691:1719	In contrast, initial spatial distribution of bacterial density or curli-producing cells does not have an effect on biofilm resistance phenotypes.
34652130	13	2	theme	emergent	2167:2174	arg1	behavior					2176:2183	the emergent behavior	2163:2183	the emergent behavior of bacterial biofilms	2163:2205	This new understanding of the emergent behavior of bacterial biofilms could aid in the development of novel engineered living materials using synthetic biology and materials science approaches.
34652130	2	3	theme	emergent	319:326	arg1	resistance					359:368	resistance	359:368	resistance to antimicrobials and disinfectants that the individual planktonic cells lack	359:446	Bacteria in biofilms display emergent biological properties, such as resistance to antimicrobials and disinfectants that the individual planktonic cells lack.
34652130	2	3	theme	emergent	319:326	arg1	properties					339:348	emergent biological properties	319:348	emergent biological properties	319:348	Bacteria in biofilms display emergent biological properties, such as resistance to antimicrobials and disinfectants that the individual planktonic cells lack.
34652130	8	4	theme	3D-printed	1311:1320	arg1	biofilms					1322:1329	The 3D-printed biofilms	1307:1329	The 3D-printed biofilms expressing cellulose and/or curli	1307:1363	The 3D-printed biofilms expressing cellulose and/or curli also show thicker anaerobic zones than nonbiofilm-forming E. coli 3D prints.
34652130	6	5	theme	extracellular-matrix	992:1011	arg1	components					1013:1022	the major extracellular-matrix components	982:1022	the major extracellular-matrix components in E. coli biofilms	982:1042	Cellulose and curli are the major extracellular-matrix components in E. coli biofilms.
34652130	6	5	theme	extracellular-matrix	992:1011	arg1	curli					972:976	curli	972:976	curli	972:976	Cellulose and curli are the major extracellular-matrix components in E. coli biofilms.
34652130	6	5	theme	extracellular-matrix	992:1011	arg1	Cellulose					958:966	Cellulose	958:966	Cellulose	958:966	Cellulose and curli are the major extracellular-matrix components in E. coli biofilms.
34652130	5	6	dep	Escherichia	895:905	arg1	coli					907:910	coli	907:910	coli	907:910	Here, we report a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture.
34652130	3	7	contain	possess	468:474	arg1	biofilms					459:466	Bacterial biofilms	449:466	Bacterial biofilms	449:466	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	3	7	contain	possess	468:474	arg2	compositions					549:560	unique extracellular matrix compositions	521:560	unique extracellular matrix compositions	521:560	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	3	7	contain	possess	468:474	arg2	arrangement					597:607	a distinct spatially patterned arrangement	566:607	a distinct spatially patterned arrangement of cells and matrix components within the biofilm	566:657	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	3	7	contain	possess	468:474	arg2	features					502:509	specialized architectural features	476:509	specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm	476:657	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	7	8	from	curli	1096:1100	arg1	matrices					1159:1166	their extracellular matrices	1139:1166	their extracellular matrices	1139:1166	We show that 3D-printed biofilms expressing either curli alone or both curli and cellulose in their extracellular matrices show higher resistance to exposure against disinfectants than 3D prints expressing either cellulose alone or no biofilm-matrix components.
34652130	9	9	theme	biofilms	1566:1573	arg1	patterning					1516:1525	emergent spatial patterning	1499:1525	emergent spatial patterning	1499:1525	Thus, the matrix composition plays a crucial role in the emergent spatial patterning and biological endurance of 3D-printed biofilms.
34652130	9	9	theme	biofilms	1566:1573	arg1	endurance					1542:1550	biological endurance	1531:1550	biological endurance	1531:1550	Thus, the matrix composition plays a crucial role in the emergent spatial patterning and biological endurance of 3D-printed biofilms.
34652130	3	10	theme	components	629:638	arg1	compositions					549:560	unique extracellular matrix compositions	521:560	unique extracellular matrix compositions	521:560	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	3	10	theme	components	629:638	arg1	arrangement					597:607	a distinct spatially patterned arrangement	566:607	a distinct spatially patterned arrangement of cells and matrix components within the biofilm	566:657	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	4	11	theme	emergent	767:774	arg1	properties					787:796	their emergent biological properties	761:796	their emergent biological properties	761:796	It is unclear which of these architectural elements of bacterial biofilms lead to the development of their emergent biological properties.
34652130	13	12	theme	new	2142:2144	arg1	understanding					2146:2158	This new understanding	2137:2158	This new understanding of the emergent behavior of bacterial biofilms	2137:2205	This new understanding of the emergent behavior of bacterial biofilms could aid in the development of novel engineered living materials using synthetic biology and materials science approaches.
34652130	1	13	theme	self-organized	212:225	arg1	nature					227:232	a highly self-organized nature	203:232	a highly self-organized nature in terms of their composition and complex architecture	203:287	Biofilms are three-dimensional (3D) bacterial communities that exhibit a highly self-organized nature in terms of their composition and complex architecture.
34652130	7	14	from	curli	1116:1120	arg1	matrices					1159:1166	their extracellular matrices	1139:1166	their extracellular matrices	1139:1166	We show that 3D-printed biofilms expressing either curli alone or both curli and cellulose in their extracellular matrices show higher resistance to exposure against disinfectants than 3D prints expressing either cellulose alone or no biofilm-matrix components.
34652130	11	15	dep	surfaces	1799:1806	arg1	cellulose					1819:1827	bacterial cellulose	1809:1827	bacterial cellulose	1809:1827	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	11	15	dep	surfaces	1799:1806	arg1	surfaces					1799:1806	different surfaces	1789:1806	different surfaces (bacterial cellulose, glass, and polystyrene)	1789:1852	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	11	15	dep	surfaces	1799:1806	arg1	glass					1830:1834	glass	1830:1834	glass	1830:1834	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	11	15	dep	surfaces	1799:1806	arg1	polystyrene					1841:1851	polystyrene	1841:1851	polystyrene	1841:1851	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	7	16	from	cellulose	1126:1134	arg1	matrices					1159:1166	their extracellular matrices	1139:1166	their extracellular matrices	1139:1166	We show that 3D-printed biofilms expressing either curli alone or both curli and cellulose in their extracellular matrices show higher resistance to exposure against disinfectants than 3D prints expressing either cellulose alone or no biofilm-matrix components.
34652130	8	17	theme	thicker	1375:1381	arg1	zones					1393:1397	thicker anaerobic zones	1375:1397	thicker anaerobic zones than nonbiofilm-forming E. coli 3D prints	1375:1439	The 3D-printed biofilms expressing cellulose and/or curli also show thicker anaerobic zones than nonbiofilm-forming E. coli 3D prints.
34652130	12	18	from	coatings	2046:2053	arg1	devices					2084:2090	medical devices	2076:2090	medical devices	2076:2090	This physical robustness highlights their potential in applications including bioremediation, protective coatings against pathogens on medical devices, or wastewater treatment, among many others.
34652130	1	19	from	nature	227:232	arg1	terms					237:241	terms	237:241	terms of their composition and complex architecture	237:287	Biofilms are three-dimensional (3D) bacterial communities that exhibit a highly self-organized nature in terms of their composition and complex architecture.
34652130	1	20	theme	three-dimensional	145:161	arg1	communities					178:188	three-dimensional (3D) bacterial communities	145:188	three-dimensional (3D) bacterial communities that exhibit a highly self-organized nature in terms of their composition and complex architecture	145:287	Biofilms are three-dimensional (3D) bacterial communities that exhibit a highly self-organized nature in terms of their composition and complex architecture.
34652130	1	20	theme	three-dimensional	145:161	arg1	Biofilms					132:139	Biofilms	132:139	Biofilms	132:139	Biofilms are three-dimensional (3D) bacterial communities that exhibit a highly self-organized nature in terms of their composition and complex architecture.
34652130	7	21	theme	extracellular	1145:1157	arg1	matrices					1159:1166	their extracellular matrices	1139:1166	their extracellular matrices	1139:1166	We show that 3D-printed biofilms expressing either curli alone or both curli and cellulose in their extracellular matrices show higher resistance to exposure against disinfectants than 3D prints expressing either cellulose alone or no biofilm-matrix components.
34652130	4	22	theme	properties	787:796	arg1	development					746:756	the development	742:756	the development of their emergent biological properties	742:796	It is unclear which of these architectural elements of bacterial biofilms lead to the development of their emergent biological properties.
34652130	13	23	theme	materials	2263:2271	arg1	development					2224:2234	the development	2220:2234	the development of novel engineered living materials using synthetic biology and materials science approaches	2220:2328	This new understanding of the emergent behavior of bacterial biofilms could aid in the development of novel engineered living materials using synthetic biology and materials science approaches.
34652130	1	24	theme	bacterial	168:176	arg1	communities					178:188	three-dimensional (3D) bacterial communities	145:188	three-dimensional (3D) bacterial communities that exhibit a highly self-organized nature in terms of their composition and complex architecture	145:287	Biofilms are three-dimensional (3D) bacterial communities that exhibit a highly self-organized nature in terms of their composition and complex architecture.
34652130	1	24	theme	bacterial	168:176	arg1	Biofilms					132:139	Biofilms	132:139	Biofilms	132:139	Biofilms are three-dimensional (3D) bacterial communities that exhibit a highly self-organized nature in terms of their composition and complex architecture.
34652130	0	25	theme	Printed	97:103	arg1	Biofilms					122:129	Three-Dimensionally Printed Escherichia coli Biofilms	77:129	Three-Dimensionally Printed Escherichia coli Biofilms	77:129	Emergent Biological Endurance Depends on Extracellular Matrix Composition of Three-Dimensionally Printed Escherichia coli Biofilms.
34652130	13	26	theme	synthetic	2279:2287	arg1	biology					2289:2295	synthetic biology	2279:2295	synthetic biology	2279:2295	This new understanding of the emergent behavior of bacterial biofilms could aid in the development of novel engineered living materials using synthetic biology and materials science approaches.
34652130	10	27	theme	initial	1589:1595	arg1	distribution					1605:1616	initial spatial distribution	1589:1616	initial spatial distribution of bacterial density or curli-producing cells	1589:1662	In contrast, initial spatial distribution of bacterial density or curli-producing cells does not have an effect on biofilm resistance phenotypes.
34652130	5	28	theme	printing-based	820:833	arg1	technique					835:843	a 3D printing-based technique	815:843	a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture	815:955	Here, we report a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture.
34652130	9	29	theme	matrix	1452:1457	arg1	composition					1459:1469	the matrix composition	1448:1469	the matrix composition	1448:1469	Thus, the matrix composition plays a crucial role in the emergent spatial patterning and biological endurance of 3D-printed biofilms.
34652130	12	30	theme	many	2124:2127	arg1	others					2129:2134	many others	2124:2134	many others	2124:2134	This physical robustness highlights their potential in applications including bioremediation, protective coatings against pathogens on medical devices, or wastewater treatment, among many others.
34652130	7	31	theme	3D-printed	1058:1067	arg1	biofilms					1069:1076	3D-printed biofilms	1058:1076	3D-printed biofilms expressing either curli alone or both curli and cellulose in their extracellular matrices	1058:1166	We show that 3D-printed biofilms expressing either curli alone or both curli and cellulose in their extracellular matrices show higher resistance to exposure against disinfectants than 3D prints expressing either cellulose alone or no biofilm-matrix components.
34652130	13	32	theme	engineered	2245:2254	arg1	materials					2263:2271	novel engineered living materials	2239:2271	novel engineered living materials using synthetic biology and materials science approaches	2239:2328	This new understanding of the emergent behavior of bacterial biofilms could aid in the development of novel engineered living materials using synthetic biology and materials science approaches.
34652130	8	33	dep	E.	1423:1424	arg1	coli					1426:1429	coli	1426:1429	coli	1426:1429	The 3D-printed biofilms expressing cellulose and/or curli also show thicker anaerobic zones than nonbiofilm-forming E. coli 3D prints.
34652130	10	34	theme	bacterial	1621:1629	arg1	density					1631:1637	bacterial density	1621:1637	bacterial density	1621:1637	In contrast, initial spatial distribution of bacterial density or curli-producing cells does not have an effect on biofilm resistance phenotypes.
34652130	3	35	theme	architectural	488:500	arg1	compositions					549:560	unique extracellular matrix compositions	521:560	unique extracellular matrix compositions	521:560	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	3	35	theme	architectural	488:500	arg1	features					502:509	specialized architectural features	476:509	specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm	476:657	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	3	35	theme	architectural	488:500	arg1	arrangement					597:607	a distinct spatially patterned arrangement	566:607	a distinct spatially patterned arrangement of cells and matrix components within the biofilm	566:657	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	0	36	theme	Emergent	0:7	arg1	Endurance					20:28	Emergent Biological Endurance	0:28	Emergent Biological Endurance	0:28	Emergent Biological Endurance Depends on Extracellular Matrix Composition of Three-Dimensionally Printed Escherichia coli Biofilms.
34652130	9	37	theme	crucial	1479:1485	arg1	role					1487:1490	a crucial role	1477:1490	a crucial role	1477:1490	Thus, the matrix composition plays a crucial role in the emergent spatial patterning and biological endurance of 3D-printed biofilms.
34652130	12	38	theme	wastewater	2096:2105	arg1	treatment					2107:2115	wastewater treatment	2096:2115	wastewater treatment	2096:2115	This physical robustness highlights their potential in applications including bioremediation, protective coatings against pathogens on medical devices, or wastewater treatment, among many others.
34652130	0	39	dep	Printed	97:103	arg1	Escherichia					105:115	Escherichia	105:115	Escherichia	105:115	Emergent Biological Endurance Depends on Extracellular Matrix Composition of Three-Dimensionally Printed Escherichia coli Biofilms.
34652130	13	40	dep	biology	2289:2295	arg1	science					2311:2317	science	2311:2317	science	2311:2317	This new understanding of the emergent behavior of bacterial biofilms could aid in the development of novel engineered living materials using synthetic biology and materials science approaches.
34652130	10	41	theme	cells	1658:1662	arg1	distribution					1605:1616	initial spatial distribution	1589:1616	initial spatial distribution of bacterial density or curli-producing cells	1589:1662	In contrast, initial spatial distribution of bacterial density or curli-producing cells does not have an effect on biofilm resistance phenotypes.
34652130	3	42	theme	extracellular	528:540	arg1	compositions					549:560	unique extracellular matrix compositions	521:560	unique extracellular matrix compositions	521:560	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	7	43	theme	biofilm-matrix	1280:1293	arg1	components					1295:1304	no biofilm-matrix components	1277:1304	no biofilm-matrix components	1277:1304	We show that 3D-printed biofilms expressing either curli alone or both curli and cellulose in their extracellular matrices show higher resistance to exposure against disinfectants than 3D prints expressing either cellulose alone or no biofilm-matrix components.
34652130	9	44	theme	emergent	1499:1506	arg1	patterning					1516:1525	emergent spatial patterning	1499:1525	emergent spatial patterning	1499:1525	Thus, the matrix composition plays a crucial role in the emergent spatial patterning and biological endurance of 3D-printed biofilms.
34652130	12	45	theme	medical	2076:2082	arg1	devices					2084:2090	medical devices	2076:2090	medical devices	2076:2090	This physical robustness highlights their potential in applications including bioremediation, protective coatings against pathogens on medical devices, or wastewater treatment, among many others.
34652130	3	46	theme	Bacterial	449:457	arg1	biofilms					459:466	Bacterial biofilms	449:466	Bacterial biofilms	449:466	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	0	47	theme	Matrix	55:60	arg1	Composition					62:72	Extracellular Matrix Composition	41:72	Extracellular Matrix Composition of Three-Dimensionally Printed Escherichia coli Biofilms	41:129	Emergent Biological Endurance Depends on Extracellular Matrix Composition of Three-Dimensionally Printed Escherichia coli Biofilms.
34652130	7	48	theme	3D	1230:1231	arg1	prints					1233:1238	3D prints	1230:1238	3D prints expressing either cellulose alone or no biofilm-matrix components	1230:1304	We show that 3D-printed biofilms expressing either curli alone or both curli and cellulose in their extracellular matrices show higher resistance to exposure against disinfectants than 3D prints expressing either cellulose alone or no biofilm-matrix components.
34652130	9	49	theme	biological	1531:1540	arg1	endurance					1542:1550	biological endurance	1531:1550	biological endurance	1531:1550	Thus, the matrix composition plays a crucial role in the emergent spatial patterning and biological endurance of 3D-printed biofilms.
34652130	4	50	theme	architectural	689:701	arg1	elements					703:710	these architectural elements	683:710	these architectural elements of bacterial biofilms	683:732	It is unclear which of these architectural elements of bacterial biofilms lead to the development of their emergent biological properties.
34652130	11	51	theme	physical	1880:1887	arg1	distortions					1889:1899	physical distortions	1880:1899	physical distortions	1880:1899	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	13	52	theme	bacterial	2188:2196	arg1	biofilms					2198:2205	bacterial biofilms	2188:2205	bacterial biofilms	2188:2205	This new understanding of the emergent behavior of bacterial biofilms could aid in the development of novel engineered living materials using synthetic biology and materials science approaches.
34652130	3	53	theme	cells	612:616	arg1	compositions					549:560	unique extracellular matrix compositions	521:560	unique extracellular matrix compositions	521:560	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	3	53	theme	cells	612:616	arg1	arrangement					597:607	a distinct spatially patterned arrangement	566:607	a distinct spatially patterned arrangement of cells and matrix components within the biofilm	566:657	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	11	54	attach	attached	1777:1784	arg1	cellulose					1819:1827	bacterial cellulose	1809:1827	bacterial cellulose	1809:1827	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	11	54	attach	attached	1777:1784	arg2	biofilms					1748:1755	these 3D-printed biofilms	1731:1755	these 3D-printed biofilms	1731:1755	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	11	54	attach	attached	1777:1784	arg1	polystyrene					1841:1851	polystyrene	1841:1851	polystyrene	1841:1851	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	11	54	attach	attached	1777:1784	arg1	glass					1830:1834	glass	1830:1834	glass	1830:1834	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	11	54	attach	attached	1777:1784	arg1	surfaces					1799:1806	different surfaces	1789:1806	different surfaces (bacterial cellulose, glass, and polystyrene)	1789:1852	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	10	55	theme	resistance	1699:1708	arg1	phenotypes					1710:1719	biofilm resistance phenotypes	1691:1719	biofilm resistance phenotypes	1691:1719	In contrast, initial spatial distribution of bacterial density or curli-producing cells does not have an effect on biofilm resistance phenotypes.
34652130	1	56	theme	architecture	276:287	arg1	terms					237:241	terms	237:241	terms of their composition and complex architecture	237:287	Biofilms are three-dimensional (3D) bacterial communities that exhibit a highly self-organized nature in terms of their composition and complex architecture.
34652130	6	57	theme	E.	1027:1028	arg1	biofilms					1035:1042	E. coli biofilms	1027:1042	E. coli biofilms	1027:1042	Cellulose and curli are the major extracellular-matrix components in E. coli biofilms.
34652130	11	58	theme	bacterial	1809:1817	arg1	cellulose					1819:1827	bacterial cellulose	1809:1827	bacterial cellulose	1809:1827	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	11	58	theme	bacterial	1809:1817	arg1	surfaces					1799:1806	different surfaces	1789:1806	different surfaces (bacterial cellulose, glass, and polystyrene)	1789:1852	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	2	59	theme	biological	328:337	arg1	resistance					359:368	resistance	359:368	resistance to antimicrobials and disinfectants that the individual planktonic cells lack	359:446	Bacteria in biofilms display emergent biological properties, such as resistance to antimicrobials and disinfectants that the individual planktonic cells lack.
34652130	2	59	theme	biological	328:337	arg1	properties					339:348	emergent biological properties	319:348	emergent biological properties	319:348	Bacteria in biofilms display emergent biological properties, such as resistance to antimicrobials and disinfectants that the individual planktonic cells lack.
34652130	12	60	theme	physical	1946:1953	arg1	robustness					1955:1964	This physical robustness	1941:1964	This physical robustness	1941:1964	This physical robustness highlights their potential in applications including bioremediation, protective coatings against pathogens on medical devices, or wastewater treatment, among many others.
34652130	6	61	from	components	1013:1022	arg1	biofilms					1035:1042	E. coli biofilms	1027:1042	E. coli biofilms	1027:1042	Cellulose and curli are the major extracellular-matrix components in E. coli biofilms.
34652130	13	62	theme	behavior	2176:2183	arg1	understanding					2146:2158	This new understanding	2137:2158	This new understanding of the emergent behavior of bacterial biofilms	2137:2205	This new understanding of the emergent behavior of bacterial biofilms could aid in the development of novel engineered living materials using synthetic biology and materials science approaches.
34652130	3	63	theme	matrix	622:627	arg1	components					629:638	matrix components	622:638	matrix components	622:638	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	8	64	theme	nonbiofilm-forming	1404:1421	arg1	prints					1434:1439	nonbiofilm-forming E. coli 3D prints	1404:1439	nonbiofilm-forming E. coli 3D prints	1404:1439	The 3D-printed biofilms expressing cellulose and/or curli also show thicker anaerobic zones than nonbiofilm-forming E. coli 3D prints.
34652130	6	65	theme	major	986:990	arg1	components					1013:1022	the major extracellular-matrix components	982:1022	the major extracellular-matrix components in E. coli biofilms	982:1042	Cellulose and curli are the major extracellular-matrix components in E. coli biofilms.
34652130	6	65	theme	major	986:990	arg1	curli					972:976	curli	972:976	curli	972:976	Cellulose and curli are the major extracellular-matrix components in E. coli biofilms.
34652130	6	65	theme	major	986:990	arg1	Cellulose					958:966	Cellulose	958:966	Cellulose	958:966	Cellulose and curli are the major extracellular-matrix components in E. coli biofilms.
34652130	8	66	theme	anaerobic	1383:1391	arg1	zones					1393:1397	thicker anaerobic zones	1375:1397	thicker anaerobic zones than nonbiofilm-forming E. coli 3D prints	1375:1439	The 3D-printed biofilms expressing cellulose and/or curli also show thicker anaerobic zones than nonbiofilm-forming E. coli 3D prints.
34652130	5	67	theme	resistance	871:880	arg1	behaviors					882:890	the emergent resistance behaviors	858:890	the emergent resistance behaviors of Escherichia coli biofilms	858:919	Here, we report a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture.
34652130	5	67	theme	resistance	871:880	arg1	function					926:933	a function	924:933	a function of their architecture	924:955	Here, we report a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture.
34652130	11	68	theme	3D-printed	1737:1746	arg1	biofilms					1748:1755	these 3D-printed biofilms	1731:1755	these 3D-printed biofilms	1731:1755	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	4	69	theme	biofilms	725:732	arg1	elements					703:710	these architectural elements	683:710	these architectural elements of bacterial biofilms	683:732	It is unclear which of these architectural elements of bacterial biofilms lead to the development of their emergent biological properties.
34652130	7	70	theme	higher	1173:1178	arg1	resistance					1180:1189	higher resistance	1173:1189	higher resistance to exposure against disinfectants than 3D prints expressing either cellulose alone or no biofilm-matrix components	1173:1304	We show that 3D-printed biofilms expressing either curli alone or both curli and cellulose in their extracellular matrices show higher resistance to exposure against disinfectants than 3D prints expressing either cellulose alone or no biofilm-matrix components.
34652130	5	71	theme	architecture	944:955	arg1	behaviors					882:890	the emergent resistance behaviors	858:890	the emergent resistance behaviors of Escherichia coli biofilms	858:919	Here, we report a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture.
34652130	5	71	theme	architecture	944:955	arg1	function					926:933	a function	924:933	a function of their architecture	924:955	Here, we report a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture.
34652130	8	72	theme	3D	1431:1432	arg1	prints					1434:1439	nonbiofilm-forming E. coli 3D prints	1404:1439	nonbiofilm-forming E. coli 3D prints	1404:1439	The 3D-printed biofilms expressing cellulose and/or curli also show thicker anaerobic zones than nonbiofilm-forming E. coli 3D prints.
34652130	5	73	theme	3D	817:818	arg1	technique					835:843	a 3D printing-based technique	815:843	a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture	815:955	Here, we report a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture.
34652130	13	74	theme	materials	2301:2309	arg1	approaches					2319:2328	synthetic biology and materials science approaches	2279:2328	synthetic biology and materials science approaches	2279:2328	This new understanding of the emergent behavior of bacterial biofilms could aid in the development of novel engineered living materials using synthetic biology and materials science approaches.
34652130	10	75	contain	have	1673:1676	arg1	distribution					1605:1616	initial spatial distribution	1589:1616	initial spatial distribution of bacterial density or curli-producing cells	1589:1662	In contrast, initial spatial distribution of bacterial density or curli-producing cells does not have an effect on biofilm resistance phenotypes.
34652130	10	75	contain	have	1673:1676	arg2	effect					1681:1686	an effect	1678:1686	an effect	1678:1686	In contrast, initial spatial distribution of bacterial density or curli-producing cells does not have an effect on biofilm resistance phenotypes.
34652130	4	76	theme	biological	776:785	arg1	properties					787:796	their emergent biological properties	761:796	their emergent biological properties	761:796	It is unclear which of these architectural elements of bacterial biofilms lead to the development of their emergent biological properties.
34652130	5	77	theme	emergent	862:869	arg1	behaviors					882:890	the emergent resistance behaviors	858:890	the emergent resistance behaviors of Escherichia coli biofilms	858:919	Here, we report a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture.
34652130	5	77	theme	emergent	862:869	arg1	function					926:933	a function	924:933	a function of their architecture	924:955	Here, we report a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture.
34652130	12	78	from	treatment	2107:2115	arg1	devices					2084:2090	medical devices	2076:2090	medical devices	2076:2090	This physical robustness highlights their potential in applications including bioremediation, protective coatings against pathogens on medical devices, or wastewater treatment, among many others.
34652130	10	79	theme	spatial	1597:1603	arg1	distribution					1605:1616	initial spatial distribution	1589:1616	initial spatial distribution of bacterial density or curli-producing cells	1589:1662	In contrast, initial spatial distribution of bacterial density or curli-producing cells does not have an effect on biofilm resistance phenotypes.
34652130	0	80	theme	Biofilms	122:129	arg1	Composition					62:72	Extracellular Matrix Composition	41:72	Extracellular Matrix Composition of Three-Dimensionally Printed Escherichia coli Biofilms	41:129	Emergent Biological Endurance Depends on Extracellular Matrix Composition of Three-Dimensionally Printed Escherichia coli Biofilms.
34652130	13	81	theme	biology	2289:2295	arg1	approaches					2319:2328	synthetic biology and materials science approaches	2279:2328	synthetic biology and materials science approaches	2279:2328	This new understanding of the emergent behavior of bacterial biofilms could aid in the development of novel engineered living materials using synthetic biology and materials science approaches.
34652130	9	82	dep	patterning	1516:1525	arg1	the					1495:1497	the	1495:1497	the	1495:1497	Thus, the matrix composition plays a crucial role in the emergent spatial patterning and biological endurance of 3D-printed biofilms.
34652130	13	83	theme	novel	2239:2243	arg1	materials					2263:2271	novel engineered living materials	2239:2271	novel engineered living materials using synthetic biology and materials science approaches	2239:2328	This new understanding of the emergent behavior of bacterial biofilms could aid in the development of novel engineered living materials using synthetic biology and materials science approaches.
34652130	8	84	theme	E.	1423:1424	arg1	prints					1434:1439	nonbiofilm-forming E. coli 3D prints	1404:1439	nonbiofilm-forming E. coli 3D prints	1404:1439	The 3D-printed biofilms expressing cellulose and/or curli also show thicker anaerobic zones than nonbiofilm-forming E. coli 3D prints.
34652130	10	85	theme	density	1631:1637	arg1	distribution					1605:1616	initial spatial distribution	1589:1616	initial spatial distribution of bacterial density or curli-producing cells	1589:1662	In contrast, initial spatial distribution of bacterial density or curli-producing cells does not have an effect on biofilm resistance phenotypes.
34652130	1	86	dep	three-dimensional	145:161	arg1	3D					164:165	3D	164:165	3D	164:165	Biofilms are three-dimensional (3D) bacterial communities that exhibit a highly self-organized nature in terms of their composition and complex architecture.
34652130	3	87	theme	unique	521:526	arg1	compositions					549:560	unique extracellular matrix compositions	521:560	unique extracellular matrix compositions	521:560	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	5	88	theme	biofilms	912:919	arg1	behaviors					882:890	the emergent resistance behaviors	858:890	the emergent resistance behaviors of Escherichia coli biofilms	858:919	Here, we report a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture.
34652130	5	88	theme	biofilms	912:919	arg1	function					926:933	a function	924:933	a function of their architecture	924:955	Here, we report a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture.
34652130	13	89	theme	living	2256:2261	arg1	materials					2263:2271	novel engineered living materials	2239:2271	novel engineered living materials using synthetic biology and materials science approaches	2239:2328	This new understanding of the emergent behavior of bacterial biofilms could aid in the development of novel engineered living materials using synthetic biology and materials science approaches.
34652130	0	90	dep	Escherichia	105:115	arg1	coli					117:120	coli	117:120	coli	117:120	Emergent Biological Endurance Depends on Extracellular Matrix Composition of Three-Dimensionally Printed Escherichia coli Biofilms.
34652130	2	91	theme	planktonic	426:435	arg1	cells					437:441	the individual planktonic cells	411:441	the individual planktonic cells	411:441	Bacteria in biofilms display emergent biological properties, such as resistance to antimicrobials and disinfectants that the individual planktonic cells lack.
34652130	2	92	theme	individual	415:424	arg1	cells					437:441	the individual planktonic cells	411:441	the individual planktonic cells	411:441	Bacteria in biofilms display emergent biological properties, such as resistance to antimicrobials and disinfectants that the individual planktonic cells lack.
34652130	0	93	theme	Extracellular	41:53	arg1	Composition					62:72	Extracellular Matrix Composition	41:72	Extracellular Matrix Composition of Three-Dimensionally Printed Escherichia coli Biofilms	41:129	Emergent Biological Endurance Depends on Extracellular Matrix Composition of Three-Dimensionally Printed Escherichia coli Biofilms.
34652130	2	94	from	Bacteria	290:297	arg1	biofilms					302:309	biofilms	302:309	biofilms	302:309	Bacteria in biofilms display emergent biological properties, such as resistance to antimicrobials and disinfectants that the individual planktonic cells lack.
34652130	3	95	theme	specialized	476:486	arg1	compositions					549:560	unique extracellular matrix compositions	521:560	unique extracellular matrix compositions	521:560	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	3	95	theme	specialized	476:486	arg1	features					502:509	specialized architectural features	476:509	specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm	476:657	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	3	95	theme	specialized	476:486	arg1	arrangement					597:607	a distinct spatially patterned arrangement	566:607	a distinct spatially patterned arrangement of cells and matrix components within the biofilm	566:657	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	10	96	theme	curli-producing	1642:1656	arg1	cells					1658:1662	curli-producing cells	1642:1662	curli-producing cells	1642:1662	In contrast, initial spatial distribution of bacterial density or curli-producing cells does not have an effect on biofilm resistance phenotypes.
34652130	3	97	theme	matrix	542:547	arg1	compositions					549:560	unique extracellular matrix compositions	521:560	unique extracellular matrix compositions	521:560	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	5	98	theme	Escherichia	895:905	arg1	biofilms					912:919	Escherichia coli biofilms	895:919	Escherichia coli biofilms	895:919	Here, we report a 3D printing-based technique for studying the emergent resistance behaviors of Escherichia coli biofilms as a function of their architecture.
34652130	9	99	theme	spatial	1508:1514	arg1	patterning					1516:1525	emergent spatial patterning	1499:1525	emergent spatial patterning	1499:1525	Thus, the matrix composition plays a crucial role in the emergent spatial patterning and biological endurance of 3D-printed biofilms.
34652130	12	100	theme	protective	2035:2044	arg1	coatings					2046:2053	protective coatings	2035:2053	protective coatings against pathogens on medical devices	2035:2090	This physical robustness highlights their potential in applications including bioremediation, protective coatings against pathogens on medical devices, or wastewater treatment, among many others.
34652130	12	101	from	bioremediation	2019:2032	arg1	devices					2084:2090	medical devices	2076:2090	medical devices	2076:2090	This physical robustness highlights their potential in applications including bioremediation, protective coatings against pathogens on medical devices, or wastewater treatment, among many others.
34652130	3	102	theme	patterned	587:595	arg1	arrangement					597:607	a distinct spatially patterned arrangement	566:607	a distinct spatially patterned arrangement of cells and matrix components within the biofilm	566:657	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	11	103	theme	different	1789:1797	arg1	cellulose					1819:1827	bacterial cellulose	1809:1827	bacterial cellulose	1809:1827	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	11	103	theme	different	1789:1797	arg1	polystyrene					1841:1851	polystyrene	1841:1851	polystyrene	1841:1851	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	11	103	theme	different	1789:1797	arg1	glass					1830:1834	glass	1830:1834	glass	1830:1834	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	11	103	theme	different	1789:1797	arg1	surfaces					1799:1806	different surfaces	1789:1806	different surfaces (bacterial cellulose, glass, and polystyrene)	1789:1852	Further, these 3D-printed biofilms could be reversibly attached to different surfaces (bacterial cellulose, glass, and polystyrene) and display resistance to physical distortions by retaining their shape and structure.
34652130	3	104	theme	distinct	568:575	arg1	arrangement					597:607	a distinct spatially patterned arrangement	566:607	a distinct spatially patterned arrangement of cells and matrix components within the biofilm	566:657	Bacterial biofilms possess specialized architectural features including unique extracellular matrix compositions and a distinct spatially patterned arrangement of cells and matrix components within the biofilm.
34652130	1	105	theme	composition	252:262	arg1	terms					237:241	terms	237:241	terms of their composition and complex architecture	237:287	Biofilms are three-dimensional (3D) bacterial communities that exhibit a highly self-organized nature in terms of their composition and complex architecture.
34652130	12	106	from	potential	1983:1991	arg1	coatings					2046:2053	protective coatings	2035:2053	protective coatings against pathogens on medical devices	2035:2090	This physical robustness highlights their potential in applications including bioremediation, protective coatings against pathogens on medical devices, or wastewater treatment, among many others.
34652130	12	106	from	potential	1983:1991	arg1	applications					1996:2007	applications	1996:2007	applications including bioremediation, protective coatings against pathogens on medical devices, or wastewater treatment	1996:2115	This physical robustness highlights their potential in applications including bioremediation, protective coatings against pathogens on medical devices, or wastewater treatment, among many others.
34652130	12	106	from	potential	1983:1991	arg1	treatment					2107:2115	wastewater treatment	2096:2115	wastewater treatment	2096:2115	This physical robustness highlights their potential in applications including bioremediation, protective coatings against pathogens on medical devices, or wastewater treatment, among many others.
34652130	12	106	from	potential	1983:1991	arg1	bioremediation					2019:2032	bioremediation	2019:2032	bioremediation	2019:2032	This physical robustness highlights their potential in applications including bioremediation, protective coatings against pathogens on medical devices, or wastewater treatment, among many others.
34652130	4	107	theme	bacterial	715:723	arg1	biofilms					725:732	bacterial biofilms	715:732	bacterial biofilms	715:732	It is unclear which of these architectural elements of bacterial biofilms lead to the development of their emergent biological properties.
34652130	1	108	theme	complex	268:274	arg1	architecture					276:287	complex architecture	268:287	complex architecture	268:287	Biofilms are three-dimensional (3D) bacterial communities that exhibit a highly self-organized nature in terms of their composition and complex architecture.
34652130	13	109	theme	biofilms	2198:2205	arg1	behavior					2176:2183	the emergent behavior	2163:2183	the emergent behavior of bacterial biofilms	2163:2205	This new understanding of the emergent behavior of bacterial biofilms could aid in the development of novel engineered living materials using synthetic biology and materials science approaches.
34652130	0	110	theme	Biological	9:18	arg1	Endurance					20:28	Emergent Biological Endurance	0:28	Emergent Biological Endurance	0:28	Emergent Biological Endurance Depends on Extracellular Matrix Composition of Three-Dimensionally Printed Escherichia coli Biofilms.
34652130	9	111	theme	3D-printed	1555:1564	arg1	biofilms					1566:1573	3D-printed biofilms	1555:1573	3D-printed biofilms	1555:1573	Thus, the matrix composition plays a crucial role in the emergent spatial patterning and biological endurance of 3D-printed biofilms.
32919539	1	0	theme	pickled	305:311	arg1	water					313:317	a pickled water	303:317	a pickled water	303:317	In this study, two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield were selected from a pickled water.
32919539	7	1	theme	shelf	1094:1098	arg1	life					1100:1103	Banana shelf life	1087:1103	Banana shelf life	1087:1103	Banana shelf life has qualitatively improved with 2% LAB added composite film and its application in food packaging has been affirmed.
32919539	0	2	with	embedded	51:58	arg1	bacteria					77:84	lactic acid bacteria	65:84	lactic acid bacteria	65:84	Cassava starch/carboxymethylcellulose edible films embedded with lactic acid bacteria to extend the shelf life of banana.
32919539	1	3	theme	different	141:149	arg1	species					151:157	two different species	137:157	two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield	137:282	In this study, two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield were selected from a pickled water.
32919539	5	4	theme	denser	725:730	arg1	structure					732:740	a denser structure	723:740	a denser structure	723:740	Moreover, L. plantarum showed uniform distribution in the CS/CMC matrix, forming a denser structure, which effectively blocked the penetration of water molecules and exhibited ultraviolet protection.
32919539	6	5	theme	transmission	957:968	arg1	rates					970:974	the water vapor and light transmission rates	931:974	the water vapor and light transmission rates	931:974	Finally, due to the intermolecular interaction between probiotics and the CS/CMC matrix, the water vapor and light transmission rates were reduced, effectively blocking water and light to prevent lipid oxidation deterioration in food packaging.
32919539	6	6	theme	intermolecular	862:875	arg1	interaction					877:887	the intermolecular interaction	858:887	the intermolecular interaction between probiotics and the CS/CMC matrix	858:928	Finally, due to the intermolecular interaction between probiotics and the CS/CMC matrix, the water vapor and light transmission rates were reduced, effectively blocking water and light to prevent lipid oxidation deterioration in food packaging.
32919539	6	7	theme	light	951:955	arg1	transmission					957:968	light transmission	951:968	light transmission	951:968	Finally, due to the intermolecular interaction between probiotics and the CS/CMC matrix, the water vapor and light transmission rates were reduced, effectively blocking water and light to prevent lipid oxidation deterioration in food packaging.
32919539	0	8	theme	shelf	100:104	arg1	life					106:109	the shelf life	96:109	the shelf life of banana	96:119	Cassava starch/carboxymethylcellulose edible films embedded with lactic acid bacteria to extend the shelf life of banana.
32919539	7	9	theme	Banana	1087:1092	arg1	life					1100:1103	Banana shelf life	1087:1103	Banana shelf life	1087:1103	Banana shelf life has qualitatively improved with 2% LAB added composite film and its application in food packaging has been affirmed.
32919539	1	10	theme	high	249:252	arg1	EPS					273:275	EPS	273:275	EPS	273:275	In this study, two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield were selected from a pickled water.
32919539	1	10	theme	high	249:252	arg1	exopolysaccharide					254:270	high exopolysaccharide	249:270	high exopolysaccharide (EPS) yield	249:282	In this study, two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield were selected from a pickled water.
32919539	0	11	theme	banana	114:119	arg1	life					106:109	the shelf life	96:109	the shelf life of banana	96:119	Cassava starch/carboxymethylcellulose edible films embedded with lactic acid bacteria to extend the shelf life of banana.
32919539	7	12	theme	%	1138:1138	arg1	film					1160:1163	2% LAB added composite film	1137:1163	2% LAB added composite film	1137:1163	Banana shelf life has qualitatively improved with 2% LAB added composite film and its application in food packaging has been affirmed.
32919539	6	13	theme	oxidation	1044:1052	arg1	deterioration					1054:1066	lipid oxidation deterioration	1038:1066	lipid oxidation deterioration in food packaging	1038:1084	Finally, due to the intermolecular interaction between probiotics and the CS/CMC matrix, the water vapor and light transmission rates were reduced, effectively blocking water and light to prevent lipid oxidation deterioration in food packaging.
32919539	5	14	theme	ultraviolet	818:828	arg1	protection					830:839	ultraviolet protection	818:839	ultraviolet protection	818:839	Moreover, L. plantarum showed uniform distribution in the CS/CMC matrix, forming a denser structure, which effectively blocked the penetration of water molecules and exhibited ultraviolet protection.
32919539	3	15	theme	antioxidant	477:487	arg1	activity					489:496	the antioxidant activity	473:496	the antioxidant activity of the composite film	473:518	After addition of probiotics, the antioxidant activity of the composite film was significantly enhanced.
32919539	1	16	theme	lactic	162:167	arg1	LAB					184:186	LAB	184:186	LAB	184:186	In this study, two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield were selected from a pickled water.
32919539	1	16	theme	lactic	162:167	arg1	bacteria					174:181	lactic acid bacteria	162:181	lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield	162:282	In this study, two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield were selected from a pickled water.
32919539	7	17	theme	LAB	1140:1142	arg1	film					1160:1163	2% LAB added composite film	1137:1163	2% LAB added composite film	1137:1163	Banana shelf life has qualitatively improved with 2% LAB added composite film and its application in food packaging has been affirmed.
32919539	4	18	theme	antioxidant	597:607	arg1	activity					609:616	the antioxidant activity	593:616	the antioxidant activity	593:616	Further, as the probiotic content increased, the antioxidant activity continuously increased.
32919539	3	19	theme	film	515:518	arg1	activity					489:496	the antioxidant activity	473:496	the antioxidant activity of the composite film	473:518	After addition of probiotics, the antioxidant activity of the composite film was significantly enhanced.
32919539	1	20	theme	acid	169:172	arg1	LAB					184:186	LAB	184:186	LAB	184:186	In this study, two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield were selected from a pickled water.
32919539	1	20	theme	acid	169:172	arg1	bacteria					174:181	lactic acid bacteria	162:181	lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield	162:282	In this study, two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield were selected from a pickled water.
32919539	7	21	theme	added	1144:1148	arg1	film					1160:1163	2% LAB added composite film	1137:1163	2% LAB added composite film	1137:1163	Banana shelf life has qualitatively improved with 2% LAB added composite film and its application in food packaging has been affirmed.
32919539	1	22	theme	exopolysaccharide	254:270	arg1	yield					278:282	high exopolysaccharide (EPS) yield	249:282	high exopolysaccharide (EPS) yield	249:282	In this study, two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield were selected from a pickled water.
32919539	1	23	theme	bacteria	174:181	arg1	species					151:157	two different species	137:157	two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield	137:282	In this study, two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield were selected from a pickled water.
32919539	7	24	theme	2	1137:1137	arg1	%					1138:1138	%	1138:1138	%	1138:1138	Banana shelf life has qualitatively improved with 2% LAB added composite film and its application in food packaging has been affirmed.
32919539	6	25	theme	lipid	1038:1042	arg1	deterioration					1054:1066	lipid oxidation deterioration	1038:1066	lipid oxidation deterioration in food packaging	1038:1084	Finally, due to the intermolecular interaction between probiotics and the CS/CMC matrix, the water vapor and light transmission rates were reduced, effectively blocking water and light to prevent lipid oxidation deterioration in food packaging.
32919539	5	26	theme	water	788:792	arg1	molecules					794:802	water molecules	788:802	water molecules	788:802	Moreover, L. plantarum showed uniform distribution in the CS/CMC matrix, forming a denser structure, which effectively blocked the penetration of water molecules and exhibited ultraviolet protection.
32919539	0	27	theme	edible	38:43	arg1	films					45:49	edible films	38:49	edible films embedded with lactic acid bacteria	38:84	Cassava starch/carboxymethylcellulose edible films embedded with lactic acid bacteria to extend the shelf life of banana.
32919539	3	28	theme	composite	505:513	arg1	film					515:518	the composite film	501:518	the composite film	501:518	After addition of probiotics, the antioxidant activity of the composite film was significantly enhanced.
32919539	5	29	theme	molecules	794:802	arg1	penetration					773:783	the penetration	769:783	the penetration of water molecules	769:802	Moreover, L. plantarum showed uniform distribution in the CS/CMC matrix, forming a denser structure, which effectively blocked the penetration of water molecules and exhibited ultraviolet protection.
32919539	5	30	theme	uniform	672:678	arg1	distribution					680:691	uniform distribution	672:691	uniform distribution	672:691	Moreover, L. plantarum showed uniform distribution in the CS/CMC matrix, forming a denser structure, which effectively blocked the penetration of water molecules and exhibited ultraviolet protection.
32919539	0	31	theme	embedded	51:58	arg1	films					45:49	edible films	38:49	edible films embedded with lactic acid bacteria	38:84	Cassava starch/carboxymethylcellulose edible films embedded with lactic acid bacteria to extend the shelf life of banana.
32919539	1	32	dep	bacteria	174:181	arg1	plantarum					204:212	Lactobacillus plantarum	190:212	Lactobacillus plantarum	190:212	In this study, two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield were selected from a pickled water.
32919539	1	32	dep	bacteria	174:181	arg1	pentosaceus					231:241	Pedocococcus pentosaceus	218:241	Pedocococcus pentosaceus	218:241	In this study, two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield were selected from a pickled water.
32919539	0	33	theme	acid	72:75	arg1	bacteria					77:84	lactic acid bacteria	65:84	lactic acid bacteria	65:84	Cassava starch/carboxymethylcellulose edible films embedded with lactic acid bacteria to extend the shelf life of banana.
32919539	6	34	theme	CS/CMC	916:921	arg1	matrix					923:928	the CS/CMC matrix	912:928	the CS/CMC matrix	912:928	Finally, due to the intermolecular interaction between probiotics and the CS/CMC matrix, the water vapor and light transmission rates were reduced, effectively blocking water and light to prevent lipid oxidation deterioration in food packaging.
32919539	6	35	theme	water	935:939	arg1	vapor					941:945	water vapor	935:945	water vapor	935:945	Finally, due to the intermolecular interaction between probiotics and the CS/CMC matrix, the water vapor and light transmission rates were reduced, effectively blocking water and light to prevent lipid oxidation deterioration in food packaging.
32919539	0	36	theme	lactic	65:70	arg1	bacteria					77:84	lactic acid bacteria	65:84	lactic acid bacteria	65:84	Cassava starch/carboxymethylcellulose edible films embedded with lactic acid bacteria to extend the shelf life of banana.
32919539	1	37	with	bacteria	174:181	arg1	yield					278:282	high exopolysaccharide (EPS) yield	249:282	high exopolysaccharide (EPS) yield	249:282	In this study, two different species of lactic acid bacteria (LAB) (Lactobacillus plantarum and Pedocococcus pentosaceus) with high exopolysaccharide (EPS) yield were selected from a pickled water.
32919539	7	38	from	application	1173:1183	arg1	packaging					1193:1201	food packaging	1188:1201	food packaging	1188:1201	Banana shelf life has qualitatively improved with 2% LAB added composite film and its application in food packaging has been affirmed.
32919539	5	39	theme	CS/CMC	700:705	arg1	matrix					707:712	the CS/CMC matrix	696:712	the CS/CMC matrix	696:712	Moreover, L. plantarum showed uniform distribution in the CS/CMC matrix, forming a denser structure, which effectively blocked the penetration of water molecules and exhibited ultraviolet protection.
32919539	6	40	theme	food	1071:1074	arg1	packaging					1076:1084	food packaging	1071:1084	food packaging	1071:1084	Finally, due to the intermolecular interaction between probiotics and the CS/CMC matrix, the water vapor and light transmission rates were reduced, effectively blocking water and light to prevent lipid oxidation deterioration in food packaging.
32919539	7	41	theme	food	1188:1191	arg1	packaging					1193:1201	food packaging	1188:1201	food packaging	1188:1201	Banana shelf life has qualitatively improved with 2% LAB added composite film and its application in food packaging has been affirmed.
32919539	6	42	from	deterioration	1054:1066	arg1	packaging					1076:1084	food packaging	1071:1084	food packaging	1071:1084	Finally, due to the intermolecular interaction between probiotics and the CS/CMC matrix, the water vapor and light transmission rates were reduced, effectively blocking water and light to prevent lipid oxidation deterioration in food packaging.
32919539	3	43	theme	probiotics	461:470	arg1	addition					449:456	addition	449:456	addition of probiotics	449:470	After addition of probiotics, the antioxidant activity of the composite film was significantly enhanced.
32919539	2	44	theme	cassava	351:357	arg1	CS					367:368	CS	367:368	CS	367:368	Further, edible films based on cassava starch (CS) were developed containing LAB, and sodium carboxymethylcellulose (CMC).
32919539	2	44	theme	cassava	351:357	arg1	starch					359:364	cassava starch	351:364	cassava starch (CS)	351:369	Further, edible films based on cassava starch (CS) were developed containing LAB, and sodium carboxymethylcellulose (CMC).
32919539	4	45	theme	probiotic	564:572	arg1	content					574:580	the probiotic content	560:580	the probiotic content	560:580	Further, as the probiotic content increased, the antioxidant activity continuously increased.
32919539	2	46	theme	sodium	406:411	arg1	CMC					437:439	CMC	437:439	CMC	437:439	Further, edible films based on cassava starch (CS) were developed containing LAB, and sodium carboxymethylcellulose (CMC).
32919539	2	46	theme	sodium	406:411	arg1	carboxymethylcellulose					413:434	sodium carboxymethylcellulose	406:434	sodium carboxymethylcellulose (CMC)	406:440	Further, edible films based on cassava starch (CS) were developed containing LAB, and sodium carboxymethylcellulose (CMC).
32919539	7	47	theme	composite	1150:1158	arg1	film					1160:1163	2% LAB added composite film	1137:1163	2% LAB added composite film	1137:1163	Banana shelf life has qualitatively improved with 2% LAB added composite film and its application in food packaging has been affirmed.
32919539	6	48	theme	vapor	941:945	arg1	rates					970:974	the water vapor and light transmission rates	931:974	the water vapor and light transmission rates	931:974	Finally, due to the intermolecular interaction between probiotics and the CS/CMC matrix, the water vapor and light transmission rates were reduced, effectively blocking water and light to prevent lipid oxidation deterioration in food packaging.
32919539	2	49	theme	edible	329:334	arg1	films					336:340	edible films	329:340	edible films based on cassava starch (CS)	329:369	Further, edible films based on cassava starch (CS) were developed containing LAB, and sodium carboxymethylcellulose (CMC).
33823405	3	0	theme	EndoS2	727:732	arg1	mutant					734:739	EndoS2 mutant	727:739	EndoS2 mutant	727:739	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	3	1	gly	deglycosylated	958:971	arg1	intermediate					982:993	deglycosylated antibody intermediate	958:993	deglycosylated antibody intermediate	958:993	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	1	2	theme	glycan	196:201	arg1	structure					203:211	well-defined glycan structure	183:211	well-defined glycan structure	183:211	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	5	3	theme	large-scale	1266:1276	arg1	production					1278:1287	large-scale production	1266:1287	large-scale production	1266:1287	We used Trastuzumab as a model to demonstrate both approaches were reliable for the large-scale production and isolation of antibodies without the residual contamination of endoglycosidase to avoid deglycosylation over storage time.
33823405	3	4	theme	type	711:714	arg1	EndoS2					716:721	the biotinylated wild type EndoS2	689:721	the biotinylated wild type EndoS2	689:721	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	2	5	theme	purification	616:627	arg1	step					629:632	additional purification step	605:632	additional purification step to remove endoglycosidase and fucosidase	605:673	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	1	6	attach	derived	383:389	arg1	culture					405:411	CHO cell culture	396:411	CHO cell culture	396:411	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	1	6	attach	derived	383:389	arg2	glycans					375:381	the non-human glycans	361:381	the non-human glycans derived from CHO cell culture	361:411	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	0	7	theme	antibodies	115:124	arg1	isolation					102:110	isolation	102:110	isolation	102:110	Development of biotinylated and magnetic bead-immobilized enzymes for efficient glyco-engineering and isolation of antibodies.
33823405	0	7	theme	antibodies	115:124	arg1	glyco-engineering					80:96	glyco-engineering	80:96	glyco-engineering	80:96	Development of biotinylated and magnetic bead-immobilized enzymes for efficient glyco-engineering and isolation of antibodies.
33823405	2	8	theme	additional	605:614	arg1	step					629:632	additional purification step	605:632	additional purification step to remove endoglycosidase and fucosidase	605:673	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	3	9	theme	antibodies	929:938	arg1	isolation					916:924	isolation	916:924	isolation	916:924	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	3	9	theme	antibodies	929:938	arg1	glyco-engineering					894:910	efficient glyco-engineering	884:910	efficient glyco-engineering	884:910	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	3	10	theme	endoglycosidases	848:863	arg1	removal					837:843	the sequential removal	822:843	the sequential removal of endoglycosidases	822:863	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	3	10	theme	endoglycosidases	848:863	arg1	fucosidase					869:878	fucosidase	869:878	fucosidase	869:878	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	4	11	theme	expensive	1020:1028	arg1	fucosidase					1030:1039	the relatively expensive fucosidase	1005:1039	the relatively expensive fucosidase	1005:1039	Notably, the relatively expensive fucosidase can be recovered to reduce the cost, and the strong affinity of streptavidin to biotin would complete the isolation of biotinylated enzymes.
33823405	1	12	theme	non-human	365:373	arg1	glycans					375:381	the non-human glycans	361:381	the non-human glycans derived from CHO cell culture	361:411	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	2	13	theme	magnetic	509:516	arg1	beads					518:522	magnetic beads	509:522	magnetic beads	509:522	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	2	14	from	EndoS	468:472	arg1	beads					518:522	magnetic beads	509:522	magnetic beads	509:522	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	3	15	with	combination	744:754	arg1	fucosidase					784:793	covalently immobilized fucosidase	761:793	covalently immobilized fucosidase	761:793	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	2	16	from	fucosidase	476:485	arg1	beads					518:522	magnetic beads	509:522	magnetic beads	509:522	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	1	17	with	antidodies	167:176	arg1	structure					203:211	well-defined glycan structure	183:211	well-defined glycan structure	183:211	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	4	18	theme	strong	1086:1091	arg1	affinity					1093:1100	the strong affinity	1082:1100	the strong affinity of streptavidin to biotin	1082:1126	Notably, the relatively expensive fucosidase can be recovered to reduce the cost, and the strong affinity of streptavidin to biotin would complete the isolation of biotinylated enzymes.
33823405	3	19	theme	deglycosylated	958:971	arg1	intermediate					982:993	deglycosylated antibody intermediate	958:993	deglycosylated antibody intermediate	958:993	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	3	20	theme	magnetic	798:805	arg1	beads					807:811	magnetic beads	798:811	magnetic beads	798:811	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	3	21	from	mutant	734:739	arg1	beads					807:811	magnetic beads	798:811	magnetic beads	798:811	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	3	21	from	mutant	734:739	arg1	combination					744:754	combination	744:754	combination with covalently immobilized fucosidase	744:793	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	3	22	theme	immobilized	772:782	arg1	fucosidase					784:793	covalently immobilized fucosidase	761:793	covalently immobilized fucosidase	761:793	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	3	23	theme	antibody	973:980	arg1	intermediate					982:993	deglycosylated antibody intermediate	958:993	deglycosylated antibody intermediate	958:993	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	1	24	theme	Fc	220:221	arg1	domain					223:228	the Fc domain	216:228	the Fc domain	216:228	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	2	25	theme	S	465:465	arg1	EndoS					468:472	wild type endoglycosidase S (EndoS)	439:473	wild type endoglycosidase S (EndoS)	439:473	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	5	26	dep	production	1278:1287	arg1	the					1262:1264	the	1262:1264	the	1262:1264	We used Trastuzumab as a model to demonstrate both approaches were reliable for the large-scale production and isolation of antibodies without the residual contamination of endoglycosidase to avoid deglycosylation over storage time.
33823405	5	27	theme	storage	1401:1407	arg1	time					1409:1412	storage time	1401:1412	storage time	1401:1412	We used Trastuzumab as a model to demonstrate both approaches were reliable for the large-scale production and isolation of antibodies without the residual contamination of endoglycosidase to avoid deglycosylation over storage time.
33823405	2	28	theme	endoglycosidase	449:463	arg1	EndoS					468:472	wild type endoglycosidase S (EndoS)	439:473	wild type endoglycosidase S (EndoS)	439:473	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	4	29	theme	enzymes	1173:1179	arg1	isolation					1147:1155	the isolation	1143:1155	the isolation of biotinylated enzymes	1143:1179	Notably, the relatively expensive fucosidase can be recovered to reduce the cost, and the strong affinity of streptavidin to biotin would complete the isolation of biotinylated enzymes.
33823405	2	30	theme	wild	439:442	arg1	EndoS					468:472	wild type endoglycosidase S (EndoS)	439:473	wild type endoglycosidase S (EndoS)	439:473	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	0	31	theme	biotinylated	15:26	arg1	Development					0:10	Development	0:10	Development of biotinylated and magnetic bead-immobilized enzymes for efficient glyco-engineering and isolation of antibodies.	0:125	Development of biotinylated and magnetic bead-immobilized enzymes for efficient glyco-engineering and isolation of antibodies.
33823405	1	32	theme	CHO	396:398	arg1	culture					405:411	CHO cell culture	396:411	CHO cell culture	396:411	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	1	33	theme	improved	238:245	arg1	ADCP					287:290	ADCP	287:290	ADCP	287:290	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	1	33	theme	improved	238:245	arg1	ADCC					278:281	ADCC	278:281	ADCC	278:281	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	1	33	theme	improved	238:245	arg1	activities					258:267	improved biological activities	238:267	improved biological activities	238:267	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	0	34	theme	bead-immobilized	41:56	arg1	enzymes					58:64	magnetic bead-immobilized enzymes	32:64	magnetic bead-immobilized enzymes	32:64	Development of biotinylated and magnetic bead-immobilized enzymes for efficient glyco-engineering and isolation of antibodies.
33823405	2	35	gly	glycoforms	586:595	arg1	antibody					577:584	homogeneous antibody glycoforms	565:595	homogeneous antibody glycoforms	565:595	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	1	36	theme	cell	400:403	arg1	culture					405:411	CHO cell culture	396:411	CHO cell culture	396:411	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	1	37	theme	biological	247:256	arg1	ADCP					287:290	ADCP	287:290	ADCP	287:290	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	1	37	theme	biological	247:256	arg1	ADCC					278:281	ADCC	278:281	ADCC	278:281	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	1	37	theme	biological	247:256	arg1	activities					258:267	improved biological activities	238:267	improved biological activities	238:267	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	0	38	theme	magnetic	32:39	arg1	enzymes					58:64	magnetic bead-immobilized enzymes	32:64	magnetic bead-immobilized enzymes	32:64	Development of biotinylated and magnetic bead-immobilized enzymes for efficient glyco-engineering and isolation of antibodies.
33823405	3	39	from	EndoS2	716:721	arg1	beads					807:811	magnetic beads	798:811	magnetic beads	798:811	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	3	39	from	EndoS2	716:721	arg1	combination					744:754	combination	744:754	combination with covalently immobilized fucosidase	744:793	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	2	40	from	mutant	499:504	arg1	beads					518:522	magnetic beads	509:522	magnetic beads	509:522	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	4	41	theme	streptavidin	1105:1116	arg1	affinity					1093:1100	the strong affinity	1082:1100	the strong affinity of streptavidin to biotin	1082:1126	Notably, the relatively expensive fucosidase can be recovered to reduce the cost, and the strong affinity of streptavidin to biotin would complete the isolation of biotinylated enzymes.
33823405	3	42	used	used	684:687	arg2	We					676:677	We	676:677	We	676:677	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	2	43	theme	EndoS2	492:497	arg1	mutant					499:504	EndoS2 mutant	492:504	EndoS2 mutant	492:504	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	1	44	theme	chemoenzymatic	131:144	arg1	likely					306:311	likely	306:311	likely	306:311	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	1	44	theme	chemoenzymatic	131:144	arg1	antidodies					167:176	The chemoenzymatic remodeled monoclonal antidodies	127:176	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain	127:228	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	0	45	theme	enzymes	58:64	arg1	Development					0:10	Development	0:10	Development of biotinylated and magnetic bead-immobilized enzymes for efficient glyco-engineering and isolation of antibodies.	0:125	Development of biotinylated and magnetic bead-immobilized enzymes for efficient glyco-engineering and isolation of antibodies.
33823405	1	46	theme	better	324:329	arg1	profile					338:344	a better safety profile	322:344	a better safety profile	322:344	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	2	47	theme	antibody	577:584	arg1	glycoforms					586:595	homogeneous antibody glycoforms	565:595	homogeneous antibody glycoforms	565:595	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	3	48	theme	biotinylated	693:704	arg1	EndoS2					716:721	the biotinylated wild type EndoS2	689:721	the biotinylated wild type EndoS2	689:721	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	1	49	theme	remodeled	146:154	arg1	likely					306:311	likely	306:311	likely	306:311	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	1	49	theme	remodeled	146:154	arg1	antidodies					167:176	The chemoenzymatic remodeled monoclonal antidodies	127:176	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain	127:228	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	1	50	theme	safety	331:336	arg1	profile					338:344	a better safety profile	322:344	a better safety profile	322:344	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	2	51	theme	homogeneous	565:575	arg1	glycoforms					586:595	homogeneous antibody glycoforms	565:595	homogeneous antibody glycoforms	565:595	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	3	52	theme	wild	706:709	arg1	EndoS2					716:721	the biotinylated wild type EndoS2	689:721	the biotinylated wild type EndoS2	689:721	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	1	53	theme	monoclonal	156:165	arg1	likely					306:311	likely	306:311	likely	306:311	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	1	53	theme	monoclonal	156:165	arg1	antidodies					167:176	The chemoenzymatic remodeled monoclonal antidodies	127:176	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain	127:228	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	5	54	used	used	1185:1188	arg2	We					1182:1183	We	1182:1183	We	1182:1183	We used Trastuzumab as a model to demonstrate both approaches were reliable for the large-scale production and isolation of antibodies without the residual contamination of endoglycosidase to avoid deglycosylation over storage time.
33823405	4	55	theme	biotinylated	1160:1171	arg1	enzymes					1173:1179	biotinylated enzymes	1160:1179	biotinylated enzymes	1160:1179	Notably, the relatively expensive fucosidase can be recovered to reduce the cost, and the strong affinity of streptavidin to biotin would complete the isolation of biotinylated enzymes.
33823405	3	56	theme	efficient	884:892	arg1	glyco-engineering					894:910	efficient glyco-engineering	884:910	efficient glyco-engineering	884:910	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
33823405	5	57	theme	antibodies	1306:1315	arg1	isolation					1293:1301	isolation	1293:1301	isolation	1293:1301	We used Trastuzumab as a model to demonstrate both approaches were reliable for the large-scale production and isolation of antibodies without the residual contamination of endoglycosidase to avoid deglycosylation over storage time.
33823405	5	57	theme	antibodies	1306:1315	arg1	production					1278:1287	large-scale production	1266:1287	large-scale production	1266:1287	We used Trastuzumab as a model to demonstrate both approaches were reliable for the large-scale production and isolation of antibodies without the residual contamination of endoglycosidase to avoid deglycosylation over storage time.
33823405	5	58	theme	endoglycosidase	1355:1369	arg1	contamination					1338:1350	the residual contamination	1325:1350	the residual contamination of endoglycosidase to avoid deglycosylation over storage time	1325:1412	We used Trastuzumab as a model to demonstrate both approaches were reliable for the large-scale production and isolation of antibodies without the residual contamination of endoglycosidase to avoid deglycosylation over storage time.
33823405	1	59	from	domain	223:228	arg1	likely					306:311	likely	306:311	likely	306:311	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	1	59	from	domain	223:228	arg1	antidodies					167:176	The chemoenzymatic remodeled monoclonal antidodies	127:176	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain	127:228	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	0	60	theme	efficient	70:78	arg1	glyco-engineering					80:96	glyco-engineering	80:96	glyco-engineering	80:96	Development of biotinylated and magnetic bead-immobilized enzymes for efficient glyco-engineering and isolation of antibodies.
33823405	2	61	theme	type	444:447	arg1	EndoS					468:472	wild type endoglycosidase S (EndoS)	439:473	wild type endoglycosidase S (EndoS)	439:473	We covalently immobilize wild type endoglycosidase S (EndoS), fucosidase, and EndoS2 mutant on magnetic beads through a linker to efficiently generate homogeneous antibody glycoforms without additional purification step to remove endoglycosidase and fucosidase.
33823405	1	62	theme	well-defined	183:194	arg1	structure					203:211	well-defined glycan structure	183:211	well-defined glycan structure	183:211	The chemoenzymatic remodeled monoclonal antidodies with well-defined glycan structure at the Fc domain display improved biological activities, such as ADCC and ADCP, and are more likely to yield a better safety profile by eliminating the non-human glycans derived from CHO cell culture.
33823405	5	63	theme	residual	1329:1336	arg1	contamination					1338:1350	the residual contamination	1325:1350	the residual contamination of endoglycosidase to avoid deglycosylation over storage time	1325:1412	We used Trastuzumab as a model to demonstrate both approaches were reliable for the large-scale production and isolation of antibodies without the residual contamination of endoglycosidase to avoid deglycosylation over storage time.
33823405	3	64	theme	sequential	826:835	arg1	removal					837:843	the sequential removal	822:843	the sequential removal of endoglycosidases	822:863	We also used the biotinylated wild type EndoS2 and EndoS2 mutant in combination with covalently immobilized fucosidase on magnetic beads to allow the sequential removal of endoglycosidases and fucosidase for efficient glyco-engineering and isolation of antibodies without purifying deglycosylated antibody intermediate.
31995003	0	0	theme	Fermentation	77:88	arg1	Condition					90:98	its Fermentation Condition	73:98	its Fermentation Condition	73:98	Screening of an Alkaline CMCase-Producing Strain and the Optimization of its Fermentation Condition.
31995003	4	1	theme	CMCase	540:545	arg1	reaction					547:554	CMCase reaction	540:554	CMCase reaction	540:554	RESULTS The optimum pH and temperature for CMCase reaction were 8.0 and 55°C, respectively.
31995003	1	2	from	conditions	301:310	arg1	activity					280:287	sufficient activity	269:287	sufficient activity at alkaline conditions	269:310	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	7	3	theme	response	930:937	arg1	methodologies					947:959	response surface methodologies	930:959	response surface methodologies based on a central composite design	930:995	To improve the alkaline CMCase production of SX9-4, fermentation parameters were selected through onefactor- at-a-time and further carried out by response surface methodologies based on a central composite design.
31995003	2	4	theme	bacterial	354:362	arg1	SX9-4					373:377	SX9-4	373:377	SX9-4	373:377	METHODS High CMCase-producing bacterial isolate, SX9-4, was screened out from soil bacteria, which was identified as Flavobacterium sp.
31995003	2	4	theme	bacterial	354:362	arg1	isolate					364:370	METHODS High CMCase-producing bacterial isolate	324:370	METHODS High CMCase-producing bacterial isolate	324:370	METHODS High CMCase-producing bacterial isolate, SX9-4, was screened out from soil bacteria, which was identified as Flavobacterium sp.
31995003	7	5	theme	SX9-4	829:833	arg1	production					815:824	the alkaline CMCase production	795:824	the alkaline CMCase production of SX9-4	795:833	To improve the alkaline CMCase production of SX9-4, fermentation parameters were selected through onefactor- at-a-time and further carried out by response surface methodologies based on a central composite design.
31995003	8	6	theme	10.53	1088:1092	arg1	conditions					1076:1085	the optimal conditions	1064:1085	the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate	1064:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	6	theme	10.53	1088:1092	arg1	glucose					1138:1144	10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose	1088:1144	glucose	1138:1144	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	5	7	theme	wide	621:624	arg1	3.0-10.6					630:637	3.0-10.6	630:637	3.0-10.6	630:637	Alkaline CMCase was stable over wide pH (3.0-10.6) and temperature (25-55°C) ranges.
31995003	5	7	theme	wide	621:624	arg1	pH					626:627	wide pH	621:627	wide pH (3.0-10.6)	621:638	Alkaline CMCase was stable over wide pH (3.0-10.6) and temperature (25-55°C) ranges.
31995003	1	8	theme	attractive	159:168	arg1	enzyme					170:175	an attractive enzyme	156:175	an attractive enzyme for the textile, laundry, pulp, and paper industries	156:228	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	1	8	theme	attractive	159:168	arg1	Cellulase					134:142	OBJECTIVE Alkaline Carboxymethyl Cellulase	101:142	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase)	101:151	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	7	9	theme	CMCase	808:813	arg1	production					815:824	the alkaline CMCase production	795:824	the alkaline CMCase production of SX9-4	795:833	To improve the alkaline CMCase production of SX9-4, fermentation parameters were selected through onefactor- at-a-time and further carried out by response surface methodologies based on a central composite design.
31995003	8	10	theme	sodium	1121:1126	arg1	conditions					1076:1085	the optimal conditions	1064:1085	the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate	1064:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	10	theme	sodium	1121:1126	arg1	glucose					1138:1144	10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose	1088:1144	glucose	1138:1144	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	4	11	dep	RESULTS	497:503	arg1	8.0					561:563	8.0	561:563	8.0	561:563	RESULTS The optimum pH and temperature for CMCase reaction were 8.0 and 55°C, respectively.
31995003	4	11	dep	RESULTS	497:503	arg1	pH					517:518	The optimum pH	505:518	The optimum pH	505:518	RESULTS The optimum pH and temperature for CMCase reaction were 8.0 and 55°C, respectively.
31995003	4	11	dep	RESULTS	497:503	arg1	55°C					569:572	55°C	569:572	55°C	569:572	RESULTS The optimum pH and temperature for CMCase reaction were 8.0 and 55°C, respectively.
31995003	2	12	theme	CMCase-producing	337:352	arg1	SX9-4					373:377	SX9-4	373:377	SX9-4	373:377	METHODS High CMCase-producing bacterial isolate, SX9-4, was screened out from soil bacteria, which was identified as Flavobacterium sp.
31995003	2	12	theme	CMCase-producing	337:352	arg1	isolate					364:370	METHODS High CMCase-producing bacterial isolate	324:370	METHODS High CMCase-producing bacterial isolate	324:370	METHODS High CMCase-producing bacterial isolate, SX9-4, was screened out from soil bacteria, which was identified as Flavobacterium sp.
31995003	0	13	theme	Condition	90:98	arg1	Screening					0:8	Screening	0:8	Screening of an Alkaline CMCase-Producing Strain	0:47	Screening of an Alkaline CMCase-Producing Strain and the Optimization of its Fermentation Condition.
31995003	0	13	theme	Condition	90:98	arg1	Optimization					57:68	the Optimization	53:68	the Optimization of its Fermentation Condition	53:98	Screening of an Alkaline CMCase-Producing Strain and the Optimization of its Fermentation Condition.
31995003	3	14	theme	16S	476:478	arg1	sequencing					485:494	16S rDNA sequencing	476:494	16S rDNA sequencing	476:494	on the basis of 16S rDNA sequencing.
31995003	6	15	dep	cations	734:740	arg1	Mn2+					742:745	Mn2+	742:745	Mn2+	742:745	Enzyme activity was significantly inhibited by the bivalent cations Mn2+ and Cu2+, and was activated by Fe2+.
31995003	6	15	dep	cations	734:740	arg1	cations					734:740	the bivalent cations Mn2+ and Cu2+	721:754	the bivalent cations Mn2+ and Cu2+	721:754	Enzyme activity was significantly inhibited by the bivalent cations Mn2+ and Cu2+, and was activated by Fe2+.
31995003	6	15	dep	cations	734:740	arg1	Cu2+					751:754	Cu2+	751:754	Cu2+	751:754	Enzyme activity was significantly inhibited by the bivalent cations Mn2+ and Cu2+, and was activated by Fe2+.
31995003	1	16	theme	commercial	240:249	arg1	preparations					251:262	commercial preparations	240:262	commercial preparations with sufficient activity at alkaline conditions	240:310	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	1	16	theme	commercial	240:249	arg1	scarce					316:321	scarce	316:321	scarce	316:321	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	2	17	theme	High	332:335	arg1	SX9-4					373:377	SX9-4	373:377	SX9-4	373:377	METHODS High CMCase-producing bacterial isolate, SX9-4, was screened out from soil bacteria, which was identified as Flavobacterium sp.
31995003	2	17	theme	High	332:335	arg1	isolate					364:370	METHODS High CMCase-producing bacterial isolate	324:370	METHODS High CMCase-producing bacterial isolate	324:370	METHODS High CMCase-producing bacterial isolate, SX9-4, was screened out from soil bacteria, which was identified as Flavobacterium sp.
31995003	5	18	theme	Alkaline	589:596	arg1	CMCase					598:603	Alkaline CMCase	589:603	Alkaline CMCase	589:603	Alkaline CMCase was stable over wide pH (3.0-10.6) and temperature (25-55°C) ranges.
31995003	2	19	theme	soil	402:405	arg1	sp					456:457	Flavobacterium sp	441:457	Flavobacterium sp	441:457	METHODS High CMCase-producing bacterial isolate, SX9-4, was screened out from soil bacteria, which was identified as Flavobacterium sp.
31995003	2	19	theme	soil	402:405	arg1	bacteria					407:414	soil bacteria	402:414	soil bacteria	402:414	METHODS High CMCase-producing bacterial isolate, SX9-4, was screened out from soil bacteria, which was identified as Flavobacterium sp.
31995003	7	20	theme	alkaline	799:806	arg1	production					815:824	the alkaline CMCase production	795:824	the alkaline CMCase production of SX9-4	795:833	To improve the alkaline CMCase production of SX9-4, fermentation parameters were selected through onefactor- at-a-time and further carried out by response surface methodologies based on a central composite design.
31995003	8	21	theme	g/L	1175:1177	arg1	conditions					1076:1085	the optimal conditions	1064:1085	the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate	1064:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	21	theme	g/L	1175:1177	arg1	oxalate					1188:1194	5.27 g/L ammonium oxalate	1170:1194	5.27 g/L ammonium oxalate	1170:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	22	theme	High	1009:1012	arg1	production					1021:1030	High CMCase production	1009:1030	CONCLUSION High CMCase production (57.18 U/mL)	998:1043	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	22	theme	High	1009:1012	arg1	U/mL					1039:1042	57.18 U/mL	1033:1042	57.18 U/mL	1033:1042	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	7	23	theme	onefactor-	882:891	arg1	at-a-time					893:901	onefactor- at-a-time	882:901	onefactor- at-a-time	882:901	To improve the alkaline CMCase production of SX9-4, fermentation parameters were selected through onefactor- at-a-time and further carried out by response surface methodologies based on a central composite design.
31995003	8	24	theme	5.27	1170:1173	arg1	conditions					1076:1085	the optimal conditions	1064:1085	the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate	1064:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	24	theme	5.27	1170:1173	arg1	oxalate					1188:1194	5.27 g/L ammonium oxalate	1170:1194	5.27 g/L ammonium oxalate	1170:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	25	theme	g/L	1134:1136	arg1	conditions					1076:1085	the optimal conditions	1064:1085	the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate	1064:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	25	theme	g/L	1134:1136	arg1	glucose					1138:1144	10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose	1088:1144	glucose	1138:1144	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	26	dep	conditions	1076:1085	arg1	peptone					1157:1163	13.71 g/L peptone	1147:1163	13.71 g/L peptone	1147:1163	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	26	dep	conditions	1076:1085	arg1	conditions					1076:1085	the optimal conditions	1064:1085	the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate	1064:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	26	dep	conditions	1076:1085	arg1	oxalate					1188:1194	5.27 g/L ammonium oxalate	1170:1194	5.27 g/L ammonium oxalate	1170:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	26	dep	conditions	1076:1085	arg1	glucose					1138:1144	10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose	1088:1144	glucose	1138:1144	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	1	27	with	preparations	251:262	arg1	activity					280:287	sufficient activity	269:287	sufficient activity at alkaline conditions	269:310	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	8	28	theme	CMCase	1014:1019	arg1	production					1021:1030	High CMCase production	1009:1030	CONCLUSION High CMCase production (57.18 U/mL)	998:1043	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	28	theme	CMCase	1014:1019	arg1	U/mL					1039:1042	57.18 U/mL	1033:1042	57.18 U/mL	1033:1042	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	29	theme	g/L	1094:1096	arg1	conditions					1076:1085	the optimal conditions	1064:1085	the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate	1064:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	29	theme	g/L	1094:1096	arg1	glucose					1138:1144	10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose	1088:1144	glucose	1138:1144	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	1	30	theme	textile	185:191	arg1	pulp					203:206	pulp	203:206	pulp	203:206	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	0	31	theme	Alkaline	16:23	arg1	Strain					42:47	an Alkaline CMCase-Producing Strain	13:47	an Alkaline CMCase-Producing Strain	13:47	Screening of an Alkaline CMCase-Producing Strain and the Optimization of its Fermentation Condition.
31995003	6	32	theme	bivalent	725:732	arg1	Mn2+					742:745	Mn2+	742:745	Mn2+	742:745	Enzyme activity was significantly inhibited by the bivalent cations Mn2+ and Cu2+, and was activated by Fe2+.
31995003	6	32	theme	bivalent	725:732	arg1	cations					734:740	the bivalent cations Mn2+ and Cu2+	721:754	the bivalent cations Mn2+ and Cu2+	721:754	Enzyme activity was significantly inhibited by the bivalent cations Mn2+ and Cu2+, and was activated by Fe2+.
31995003	6	32	theme	bivalent	725:732	arg1	Cu2+					751:754	Cu2+	751:754	Cu2+	751:754	Enzyme activity was significantly inhibited by the bivalent cations Mn2+ and Cu2+, and was activated by Fe2+.
31995003	1	33	theme	OBJECTIVE	101:109	arg1	enzyme					170:175	an attractive enzyme	156:175	an attractive enzyme for the textile, laundry, pulp, and paper industries	156:228	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	1	33	theme	OBJECTIVE	101:109	arg1	CMCase					145:150	CMCase	145:150	CMCase	145:150	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	1	33	theme	OBJECTIVE	101:109	arg1	Cellulase					134:142	OBJECTIVE Alkaline Carboxymethyl Cellulase	101:142	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase)	101:151	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	1	34	theme	sufficient	269:278	arg1	activity					280:287	sufficient activity	269:287	sufficient activity at alkaline conditions	269:310	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	1	35	theme	Alkaline	111:118	arg1	enzyme					170:175	an attractive enzyme	156:175	an attractive enzyme for the textile, laundry, pulp, and paper industries	156:228	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	1	35	theme	Alkaline	111:118	arg1	CMCase					145:150	CMCase	145:150	CMCase	145:150	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	1	35	theme	Alkaline	111:118	arg1	Cellulase					134:142	OBJECTIVE Alkaline Carboxymethyl Cellulase	101:142	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase)	101:151	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	1	36	theme	laundry	194:200	arg1	pulp					203:206	pulp	203:206	pulp	203:206	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	0	37	theme	Strain	42:47	arg1	Screening					0:8	Screening	0:8	Screening of an Alkaline CMCase-Producing Strain	0:47	Screening of an Alkaline CMCase-Producing Strain and the Optimization of its Fermentation Condition.
31995003	0	37	theme	Strain	42:47	arg1	Optimization					57:68	the Optimization	53:68	the Optimization of its Fermentation Condition	53:98	Screening of an Alkaline CMCase-Producing Strain and the Optimization of its Fermentation Condition.
31995003	8	38	theme	ammonium	1179:1186	arg1	conditions					1076:1085	the optimal conditions	1064:1085	the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate	1064:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	38	theme	ammonium	1179:1186	arg1	oxalate					1188:1194	5.27 g/L ammonium oxalate	1170:1194	5.27 g/L ammonium oxalate	1170:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	0	39	theme	CMCase-Producing	25:40	arg1	Strain					42:47	an Alkaline CMCase-Producing Strain	13:47	an Alkaline CMCase-Producing Strain	13:47	Screening of an Alkaline CMCase-Producing Strain and the Optimization of its Fermentation Condition.
31995003	8	40	theme	g/L	1153:1155	arg1	peptone					1157:1163	13.71 g/L peptone	1147:1163	13.71 g/L peptone	1147:1163	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	40	theme	g/L	1153:1155	arg1	conditions					1076:1085	the optimal conditions	1064:1085	the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate	1064:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	41	dep	CONCLUSION	998:1007	arg1	production					1021:1030	High CMCase production	1009:1030	CONCLUSION High CMCase production (57.18 U/mL)	998:1043	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	41	dep	CONCLUSION	998:1007	arg1	U/mL					1039:1042	57.18 U/mL	1033:1042	57.18 U/mL	1033:1042	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	1	42	theme	pulp	203:206	arg1	industries					219:228	the textile, laundry, pulp, and paper industries	181:228	the textile, laundry, pulp, and paper industries	181:228	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	2	43	theme	Flavobacterium	441:454	arg1	sp					456:457	Flavobacterium sp	441:457	Flavobacterium sp	441:457	METHODS High CMCase-producing bacterial isolate, SX9-4, was screened out from soil bacteria, which was identified as Flavobacterium sp.
31995003	2	43	theme	Flavobacterium	441:454	arg1	bacteria					407:414	soil bacteria	402:414	soil bacteria	402:414	METHODS High CMCase-producing bacterial isolate, SX9-4, was screened out from soil bacteria, which was identified as Flavobacterium sp.
31995003	1	44	theme	alkaline	292:299	arg1	conditions					301:310	alkaline conditions	292:310	alkaline conditions	292:310	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	7	45	theme	central	972:978	arg1	design					990:995	a central composite design	970:995	a central composite design	970:995	To improve the alkaline CMCase production of SX9-4, fermentation parameters were selected through onefactor- at-a-time and further carried out by response surface methodologies based on a central composite design.
31995003	1	46	theme	Carboxymethyl	120:132	arg1	enzyme					170:175	an attractive enzyme	156:175	an attractive enzyme for the textile, laundry, pulp, and paper industries	156:228	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	1	46	theme	Carboxymethyl	120:132	arg1	CMCase					145:150	CMCase	145:150	CMCase	145:150	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	1	46	theme	Carboxymethyl	120:132	arg1	Cellulase					134:142	OBJECTIVE Alkaline Carboxymethyl Cellulase	101:142	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase)	101:151	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	5	47	theme	pH	626:627	arg1	ranges					666:671	wide pH (3.0-10.6) and temperature (25-55°C) ranges	621:671	wide pH (3.0-10.6) and temperature (25-55°C) ranges	621:671	Alkaline CMCase was stable over wide pH (3.0-10.6) and temperature (25-55°C) ranges.
31995003	3	48	theme	rDNA	480:483	arg1	sequencing					485:494	16S rDNA sequencing	476:494	16S rDNA sequencing	476:494	on the basis of 16S rDNA sequencing.
31995003	2	49	theme	METHODS	324:330	arg1	SX9-4					373:377	SX9-4	373:377	SX9-4	373:377	METHODS High CMCase-producing bacterial isolate, SX9-4, was screened out from soil bacteria, which was identified as Flavobacterium sp.
31995003	2	49	theme	METHODS	324:330	arg1	isolate					364:370	METHODS High CMCase-producing bacterial isolate	324:370	METHODS High CMCase-producing bacterial isolate	324:370	METHODS High CMCase-producing bacterial isolate, SX9-4, was screened out from soil bacteria, which was identified as Flavobacterium sp.
31995003	4	50	theme	optimum	509:515	arg1	8.0					561:563	8.0	561:563	8.0	561:563	RESULTS The optimum pH and temperature for CMCase reaction were 8.0 and 55°C, respectively.
31995003	4	50	theme	optimum	509:515	arg1	pH					517:518	The optimum pH	505:518	The optimum pH	505:518	RESULTS The optimum pH and temperature for CMCase reaction were 8.0 and 55°C, respectively.
31995003	7	51	theme	composite	980:988	arg1	design					990:995	a central composite design	970:995	a central composite design	970:995	To improve the alkaline CMCase production of SX9-4, fermentation parameters were selected through onefactor- at-a-time and further carried out by response surface methodologies based on a central composite design.
31995003	8	52	theme	optimal	1068:1074	arg1	peptone					1157:1163	13.71 g/L peptone	1147:1163	13.71 g/L peptone	1147:1163	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	52	theme	optimal	1068:1074	arg1	conditions					1076:1085	the optimal conditions	1064:1085	the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate	1064:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	52	theme	optimal	1068:1074	arg1	oxalate					1188:1194	5.27 g/L ammonium oxalate	1170:1194	5.27 g/L ammonium oxalate	1170:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	52	theme	optimal	1068:1074	arg1	glucose					1138:1144	10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose	1088:1144	glucose	1138:1144	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	3	53	dep	sequencing	485:494	arg1	basis					467:471	basis	467:471	basis	467:471	on the basis of 16S rDNA sequencing.
31995003	3	53	dep	sequencing	485:494	arg1	the					463:465	the	463:465	the	463:465	on the basis of 16S rDNA sequencing.
31995003	5	54	theme	temperature	644:654	arg1	ranges					666:671	wide pH (3.0-10.6) and temperature (25-55°C) ranges	621:671	wide pH (3.0-10.6) and temperature (25-55°C) ranges	621:671	Alkaline CMCase was stable over wide pH (3.0-10.6) and temperature (25-55°C) ranges.
31995003	1	55	dep	pulp	203:206	arg1	the					181:183	the	181:183	the	181:183	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	7	56	theme	surface	939:945	arg1	methodologies					947:959	response surface methodologies	930:959	response surface methodologies based on a central composite design	930:995	To improve the alkaline CMCase production of SX9-4, fermentation parameters were selected through onefactor- at-a-time and further carried out by response surface methodologies based on a central composite design.
31995003	7	57	theme	fermentation	836:847	arg1	parameters					849:858	fermentation parameters	836:858	fermentation parameters	836:858	To improve the alkaline CMCase production of SX9-4, fermentation parameters were selected through onefactor- at-a-time and further carried out by response surface methodologies based on a central composite design.
31995003	1	58	theme	paper	213:217	arg1	industries					219:228	the textile, laundry, pulp, and paper industries	181:228	the textile, laundry, pulp, and paper industries	181:228	OBJECTIVE Alkaline Carboxymethyl Cellulase (CMCase) is an attractive enzyme for the textile, laundry, pulp, and paper industries; however, commercial preparations with sufficient activity at alkaline conditions are scarce.
31995003	6	59	theme	Enzyme	674:679	arg1	activity					681:688	Enzyme activity	674:688	Enzyme activity	674:688	Enzyme activity was significantly inhibited by the bivalent cations Mn2+ and Cu2+, and was activated by Fe2+.
31995003	8	60	theme	carboxymethylcellulose	1098:1119	arg1	conditions					1076:1085	the optimal conditions	1064:1085	the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate	1064:1194	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
31995003	8	60	theme	carboxymethylcellulose	1098:1119	arg1	glucose					1138:1144	10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose	1088:1144	glucose	1138:1144	CONCLUSION High CMCase production (57.18 U/mL) was achieved under the optimal conditions: 10.53 g/L carboxymethylcellulose sodium, 7.74 g/L glucose, 13.71 g/L peptone, and 5.27 g/L ammonium oxalate.
33049876	6	0	theme	solution	596:603	arg1	concentration					566:578	concentration	566:578	concentration of the alginate solution	566:603	Stage 3: effect of concentration of the alginate solution.
33049876	9	1	theme	high	932:935	arg1	ratios					946:951	high catalyst ratios	932:951	high catalyst ratios	932:951	High alginate amounts increase the storage modulus of synthesized hybrids, and high catalyst ratios reduce their stability.
33049876	6	2	theme	alginate	587:594	arg1	solution					596:603	the alginate solution	583:603	the alginate solution	583:603	Stage 3: effect of concentration of the alginate solution.
33049876	7	3	theme	silica	719:724	arg1	nature					736:741	the silica precursor nature	715:741	the silica precursor nature	715:741	The hydrolysis-condensation reactions of the silica precursors were regulated by the alginate concentration, the silica precursor nature, and the HCl/inorganic/H2O ratio.
33049876	2	4	from	synthesis	183:191	arg1	tetraethoxysilane					217:233	tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors	217:290	tetraethoxysilane	217:233	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	2	4	from	synthesis	183:191	arg1	precursors					281:290	tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors	217:290	precursors	281:290	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	2	4	from	synthesis	183:191	arg1	APTES					274:278	APTES	274:278	APTES	274:278	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	2	4	from	synthesis	183:191	arg1	TEOS					236:239	TEOS	236:239	TEOS	236:239	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	2	4	from	synthesis	183:191	arg1	matrix					307:312	an alginate matrix	295:312	an alginate matrix	295:312	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	7	5	theme	hydrolysis-condensation	610:632	arg1	reactions					634:642	The hydrolysis-condensation reactions	606:642	The hydrolysis-condensation reactions of the silica precursors	606:667	The hydrolysis-condensation reactions of the silica precursors were regulated by the alginate concentration, the silica precursor nature, and the HCl/inorganic/H2O ratio.
33049876	10	6	from	application	1124:1134	arg1	engineering					1146:1156	tissue engineering	1139:1156	tissue engineering	1139:1156	Compositions with alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26, and without catalyst are suitable to evaluation for their application in tissue engineering.
33049876	4	7	theme	water	468:472	arg1	effect					458:463	effect	458:463	Stage 1: effect of water and catalyst ratios.	449:493	Stage 1: effect of water and catalyst ratios.
33049876	4	8	dep	Stage	449:453	arg1	effect					458:463	effect	458:463	Stage 1: effect of water and catalyst ratios.	449:493	Stage 1: effect of water and catalyst ratios.
33049876	3	9	theme	experimental	330:341	arg1	parameters					343:352	The experimental parameters	326:352	The experimental parameters	326:352	The experimental parameters were analyzed in three consecutive stages to obtain hybrid materials with specific properties.
33049876	9	10	theme	High	853:856	arg1	amounts					867:873	High alginate amounts	853:873	High alginate amounts	853:873	High alginate amounts increase the storage modulus of synthesized hybrids, and high catalyst ratios reduce their stability.
33049876	8	11	theme	silica	838:843	arg1	chains					845:850	longer silica chains	831:850	longer silica chains	831:850	Hybrids prepared with both silica precursors generate longer silica chains.
33049876	8	12	theme	longer	831:836	arg1	chains					845:850	longer silica chains	831:850	longer silica chains	831:850	Hybrids prepared with both silica precursors generate longer silica chains.
33049876	4	13	theme	catalyst	478:485	arg1	effect					458:463	effect	458:463	Stage 1: effect of water and catalyst ratios.	449:493	Stage 1: effect of water and catalyst ratios.
33049876	3	14	with	materials	413:421	arg1	properties					437:446	specific properties	428:446	specific properties	428:446	The experimental parameters were analyzed in three consecutive stages to obtain hybrid materials with specific properties.
33049876	3	15	theme	consecutive	377:387	arg1	stages					389:394	three consecutive stages	371:394	three consecutive stages	371:394	The experimental parameters were analyzed in three consecutive stages to obtain hybrid materials with specific properties.
33049876	2	16	from	tetraethoxysilane	217:233	arg1	synthesis					183:191	The in-situ synthesis	171:191	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix	171:312	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	2	16	from	tetraethoxysilane	217:233	arg1	networks					203:210	silica networks	196:210	silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors	196:290	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	10	17	dep	5	1015:1015	arg1	wt/v					1024:1027	wt/v	1024:1027	wt/v	1024:1027	Compositions with alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26, and without catalyst are suitable to evaluation for their application in tissue engineering.
33049876	6	18	theme	concentration	566:578	arg1	effect					556:561	effect	556:561	Stage 3: effect of concentration of the alginate solution.	547:604	Stage 3: effect of concentration of the alginate solution.
33049876	7	19	theme	silica	651:656	arg1	precursors					658:667	the silica precursors	647:667	the silica precursors	647:667	The hydrolysis-condensation reactions of the silica precursors were regulated by the alginate concentration, the silica precursor nature, and the HCl/inorganic/H2O ratio.
33049876	2	20	theme	alginate	298:305	arg1	matrix					307:312	an alginate matrix	295:312	an alginate matrix	295:312	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	3	21	theme	specific	428:435	arg1	properties					437:446	specific properties	428:446	specific properties	428:446	The experimental parameters were analyzed in three consecutive stages to obtain hybrid materials with specific properties.
33049876	0	22	theme	SILICA-ALGINATE	21:35	arg1	HYBRID					37:42	IN-SITU SILICA-ALGINATE HYBRID	13:42	IN-SITU SILICA-ALGINATE HYBRID	13:42	SYNTHESIS OF IN-SITU SILICA-ALGINATE HYBRID HYDROGELS BY A SOL-GEL ROUTE.
33049876	6	23	dep	Stage	547:551	arg1	effect					556:561	effect	556:561	Stage 3: effect of concentration of the alginate solution.	547:604	Stage 3: effect of concentration of the alginate solution.
33049876	1	24	theme	silica-alginate	93:107	arg1	hydrogels					116:124	silica-alginate hybrid hydrogels	93:124	silica-alginate hybrid hydrogels	93:124	The preparation of silica-alginate hybrid hydrogels by a sol-gel route is proposed in this work.
33049876	0	25	theme	IN-SITU	13:19	arg1	HYBRID					37:42	IN-SITU SILICA-ALGINATE HYBRID	13:42	IN-SITU SILICA-ALGINATE HYBRID	13:42	SYNTHESIS OF IN-SITU SILICA-ALGINATE HYBRID HYDROGELS BY A SOL-GEL ROUTE.
33049876	4	26	dep	water	468:472	arg1	ratios					487:492	ratios	487:492	ratios	487:492	Stage 1: effect of water and catalyst ratios.
33049876	1	27	theme	hybrid	109:114	arg1	hydrogels					116:124	silica-alginate hybrid hydrogels	93:124	silica-alginate hybrid hydrogels	93:124	The preparation of silica-alginate hybrid hydrogels by a sol-gel route is proposed in this work.
33049876	3	28	theme	hybrid	406:411	arg1	materials					413:421	hybrid materials	406:421	hybrid materials with specific properties	406:446	The experimental parameters were analyzed in three consecutive stages to obtain hybrid materials with specific properties.
33049876	10	29	with	Compositions	977:988	arg1	content					1004:1010	alginate content	995:1010	alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26,	995:1064	Compositions with alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26, and without catalyst are suitable to evaluation for their application in tissue engineering.
33049876	7	30	theme	alginate	691:698	arg1	concentration					700:712	the alginate concentration	687:712	the alginate concentration	687:712	The hydrolysis-condensation reactions of the silica precursors were regulated by the alginate concentration, the silica precursor nature, and the HCl/inorganic/H2O ratio.
33049876	7	31	theme	precursors	658:667	arg1	reactions					634:642	The hydrolysis-condensation reactions	606:642	The hydrolysis-condensation reactions of the silica precursors	606:667	The hydrolysis-condensation reactions of the silica precursors were regulated by the alginate concentration, the silica precursor nature, and the HCl/inorganic/H2O ratio.
33049876	0	32	theme	HYBRID	37:42	arg1	SYNTHESIS					0:8	SYNTHESIS	0:8	SYNTHESIS OF IN-SITU SILICA-ALGINATE HYBRID	0:42	SYNTHESIS OF IN-SITU SILICA-ALGINATE HYBRID HYDROGELS BY A SOL-GEL ROUTE.
33049876	5	33	theme	inorganic	518:526	arg1	ratio					540:544	the inorganic precursor's ratio	514:544	the inorganic precursor's ratio	514:544	Stage 2: effect of the inorganic precursor's ratio.
33049876	9	34	theme	catalyst	937:944	arg1	ratios					946:951	high catalyst ratios	932:951	high catalyst ratios	932:951	High alginate amounts increase the storage modulus of synthesized hybrids, and high catalyst ratios reduce their stability.
33049876	9	35	theme	storage	888:894	arg1	modulus					896:902	the storage modulus	884:902	the storage modulus of synthesized hybrids	884:925	High alginate amounts increase the storage modulus of synthesized hybrids, and high catalyst ratios reduce their stability.
33049876	1	36	theme	hydrogels	116:124	arg1	preparation					78:88	The preparation	74:88	The preparation of silica-alginate hybrid hydrogels by a sol-gel route	74:143	The preparation of silica-alginate hybrid hydrogels by a sol-gel route is proposed in this work.
33049876	10	37	theme	weight	1043:1048	arg1	%					1029:1029	5 and 8 (wt/v)%	1015:1029	5 and 8 (wt/v)%	1015:1029	Compositions with alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26, and without catalyst are suitable to evaluation for their application in tissue engineering.
33049876	10	37	theme	weight	1043:1048	arg1	ratio					1050:1054	TEOS/APTES weight ratio	1032:1054	TEOS/APTES weight ratio of 74/26	1032:1063	Compositions with alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26, and without catalyst are suitable to evaluation for their application in tissue engineering.
33049876	9	38	theme	alginate	858:865	arg1	amounts					867:873	High alginate amounts	853:873	High alginate amounts	853:873	High alginate amounts increase the storage modulus of synthesized hybrids, and high catalyst ratios reduce their stability.
33049876	2	39	theme	silica	196:201	arg1	networks					203:210	silica networks	196:210	silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors	196:290	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	2	40	theme	networks	203:210	arg1	synthesis					183:191	The in-situ synthesis	171:191	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix	171:312	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	7	41	theme	HCl/inorganic/H2O	752:768	arg1	ratio					770:774	the HCl/inorganic/H2O ratio	748:774	the HCl/inorganic/H2O ratio	748:774	The hydrolysis-condensation reactions of the silica precursors were regulated by the alginate concentration, the silica precursor nature, and the HCl/inorganic/H2O ratio.
33049876	2	42	theme	aminopropyltriethoxysilane	246:271	arg1	precursors					281:290	tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors	217:290	precursors	281:290	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	2	42	theme	aminopropyltriethoxysilane	246:271	arg1	APTES					274:278	APTES	274:278	APTES	274:278	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	8	43	theme	silica	804:809	arg1	precursors					811:820	both silica precursors	799:820	both silica precursors	799:820	Hybrids prepared with both silica precursors generate longer silica chains.
33049876	9	44	theme	synthesized	907:917	arg1	hybrids					919:925	synthesized hybrids	907:925	synthesized hybrids	907:925	High alginate amounts increase the storage modulus of synthesized hybrids, and high catalyst ratios reduce their stability.
33049876	10	45	theme	%	1029:1029	arg1	content					1004:1010	alginate content	995:1010	alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26,	995:1064	Compositions with alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26, and without catalyst are suitable to evaluation for their application in tissue engineering.
33049876	5	46	dep	Stage	495:499	arg1	effect					504:509	effect	504:509	Stage 2: effect of the inorganic precursor's ratio.	495:545	Stage 2: effect of the inorganic precursor's ratio.
33049876	1	47	theme	sol-gel	131:137	arg1	route					139:143	a sol-gel route	129:143	a sol-gel route	129:143	The preparation of silica-alginate hybrid hydrogels by a sol-gel route is proposed in this work.
33049876	2	48	from	precursors	281:290	arg1	synthesis					183:191	The in-situ synthesis	171:191	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix	171:312	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	2	48	from	precursors	281:290	arg1	networks					203:210	silica networks	196:210	silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors	196:290	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	9	49	theme	hybrids	919:925	arg1	modulus					896:902	the storage modulus	884:902	the storage modulus of synthesized hybrids	884:925	High alginate amounts increase the storage modulus of synthesized hybrids, and high catalyst ratios reduce their stability.
33049876	2	50	theme	in-situ	175:181	arg1	synthesis					183:191	The in-situ synthesis	171:191	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix	171:312	The in-situ synthesis of silica networks from tetraethoxysilane (TEOS) and aminopropyltriethoxysilane (APTES) precursors in an alginate matrix is assayed.
33049876	7	51	theme	precursor	726:734	arg1	nature					736:741	the silica precursor nature	715:741	the silica precursor nature	715:741	The hydrolysis-condensation reactions of the silica precursors were regulated by the alginate concentration, the silica precursor nature, and the HCl/inorganic/H2O ratio.
33049876	0	52	theme	SOL-GEL	59:65	arg1	ROUTE					67:71	A SOL-GEL ROUTE	57:71	A SOL-GEL ROUTE	57:71	SYNTHESIS OF IN-SITU SILICA-ALGINATE HYBRID HYDROGELS BY A SOL-GEL ROUTE.
33049876	10	53	theme	74/26	1059:1063	arg1	%					1029:1029	5 and 8 (wt/v)%	1015:1029	5 and 8 (wt/v)%	1015:1029	Compositions with alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26, and without catalyst are suitable to evaluation for their application in tissue engineering.
33049876	10	53	theme	74/26	1059:1063	arg1	ratio					1050:1054	TEOS/APTES weight ratio	1032:1054	TEOS/APTES weight ratio of 74/26	1032:1063	Compositions with alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26, and without catalyst are suitable to evaluation for their application in tissue engineering.
33049876	10	54	theme	alginate	995:1002	arg1	content					1004:1010	alginate content	995:1010	alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26,	995:1064	Compositions with alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26, and without catalyst are suitable to evaluation for their application in tissue engineering.
33049876	10	55	theme	TEOS/APTES	1032:1041	arg1	%					1029:1029	5 and 8 (wt/v)%	1015:1029	5 and 8 (wt/v)%	1015:1029	Compositions with alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26, and without catalyst are suitable to evaluation for their application in tissue engineering.
33049876	10	55	theme	TEOS/APTES	1032:1041	arg1	ratio					1050:1054	TEOS/APTES weight ratio	1032:1054	TEOS/APTES weight ratio of 74/26	1032:1063	Compositions with alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26, and without catalyst are suitable to evaluation for their application in tissue engineering.
33049876	10	56	theme	tissue	1139:1144	arg1	engineering					1146:1156	tissue engineering	1139:1156	tissue engineering	1139:1156	Compositions with alginate content of 5 and 8 (wt/v)%, TEOS/APTES weight ratio of 74/26, and without catalyst are suitable to evaluation for their application in tissue engineering.
33245048	4	0	theme	biocompatible	892:904	arg1	scaffolds					924:932	biocompatible composite bilayer scaffolds	892:932	biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation)	892:1157	Therefore, we developed a procedure to obtain biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation).
33245048	8	1	theme	adipose-derived	1874:1888	arg1	cells					1898:1902	subcutaneous adipose-derived stromal cells	1861:1902	subcutaneous adipose-derived stromal cells	1861:1902	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	5	2	theme	base	1234:1237	arg1	component					1239:1247	a base component	1232:1247	a base component for these scaffolds	1232:1267	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	2	theme	base	1234:1237	arg1	alginate					1171:1178	The sodium alginate	1160:1178	The sodium alginate (SA)	1160:1183	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	7	3	theme	SA/CL/FG	1501:1508	arg1	ratio					1510:1514	the SA/CL/FG ratio	1497:1514	the SA/CL/FG ratio	1497:1514	By manipulating the SA/CL/FG ratio we managed to obtain sponge scaffolds with highly interconnected porous structures, with an average pore size ranging from 60 to 300 μm, and sufficient tensile strength (3.12-5.26 MPa).
33245048	4	4	theme	bilayer	916:922	arg1	scaffolds					924:932	biocompatible composite bilayer scaffolds	892:932	biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation)	892:1157	Therefore, we developed a procedure to obtain biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation).
33245048	9	5	theme	subcutaneous	2199:2210	arg1	model					2225:2229	the subcutaneous implantation model	2195:2229	the subcutaneous implantation model in laboratory mice	2195:2248	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	8	6	theme	scaffolds	1706:1714	arg1	biocompatibility					1716:1731	The scaffolds biocompatibility	1702:1731	The scaffolds biocompatibility with the major human skin cell types	1702:1768	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	3	7	theme	reasonable	710:719	arg1	approach					721:728	a reasonable approach	708:728	a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment	708:843	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	3	7	theme	reasonable	710:719	arg1	sufficient					652:661	sufficient	652:661	sufficient	652:661	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	3	7	theme	reasonable	710:719	arg1	development					529:539	the development	525:539	the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane	525:645	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	3	8	theme	clinically-relevant	751:769	arg1	skin					771:774	clinically-relevant skin	751:774	clinically-relevant skin	751:774	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	8	9	theme	side	1919:1922	arg1	biocompatibility					1924:1939	the film side biocompatibility	1910:1939	the film side biocompatibility	1910:1939	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	8	10	theme	major	1742:1746	arg1	types					1764:1768	the major human skin cell types	1738:1768	the major human skin cell types	1738:1768	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	3	11	theme	porous	566:571	arg1	scaffold					573:580	a fibroblast-friendly porous scaffold	544:580	a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane	544:645	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	8	12	theme	skin	1754:1757	arg1	types					1764:1768	the major human skin cell types	1738:1768	the major human skin cell types	1738:1768	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	2	13	theme	skin	217:220	arg1	epidermis					227:235	the epidermis	223:235	the epidermis	223:235	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	2	13	theme	skin	217:220	arg1	layer					204:208	The outer protective layer	183:208	The outer protective layer of the skin	183:220	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	8	14	theme	human	1966:1970	arg1	keratinocytes					1972:1984	primary human keratinocytes	1958:1984	primary human keratinocytes	1958:1984	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	4	15	theme	spongy	947:952	arg1	body					966:969	a spongy dermis-like body	945:969	a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation)	945:1157	Therefore, we developed a procedure to obtain biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation).
33245048	3	16	theme	burn	830:833	arg1	treatment					835:843	reconstructive dermatology and burn treatment	799:843	treatment	835:843	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	3	17	theme	basement	629:636	arg1	membrane					638:645	the basement membrane	625:645	the basement membrane	625:645	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	1	18	theme	types	126:130	arg1	skin					87:90	The skin	83:90	The skin	83:90	The skin is a combination of two different types of tissue-epithelial and connective (mesenchymal).
33245048	1	18	theme	types	126:130	arg1	combination					97:107	a combination	95:107	a combination of two different types of tissue-epithelial and connective (mesenchymal)	95:180	The skin is a combination of two different types of tissue-epithelial and connective (mesenchymal).
33245048	4	19	theme	multipotent	1030:1040	arg1	cell					1050:1053	multipotent stromal cell	1030:1053	multipotent stromal cell	1030:1053	Therefore, we developed a procedure to obtain biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation).
33245048	5	20	from	additives	1328:1336	arg1	concentrations					1350:1363	variable concentrations	1341:1363	variable concentrations	1341:1363	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	9	21	theme	bilayer	2024:2030	arg1	scaffolds					2047:2055	bilayer alginate-based scaffolds	2024:2055	bilayer alginate-based scaffolds	2024:2055	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	6	22	theme	SA-based	1394:1401	arg1	biodegradation					1412:1425	composite SA-based scaffold biodegradation	1384:1425	composite SA-based scaffold biodegradation	1384:1425	The slow rates of composite SA-based scaffold biodegradation were achieved by using Ba2+ as cross-linking cations.
33245048	7	23	dep	300	1645:1647	arg1	to					1642:1643	to	1642:1643	to	1642:1643	By manipulating the SA/CL/FG ratio we managed to obtain sponge scaffolds with highly interconnected porous structures, with an average pore size ranging from 60 to 300 μm, and sufficient tensile strength (3.12-5.26 MPa).
33245048	8	24	theme	scaffold	1799:1806	arg1	compartment					1815:1825	the scaffold sponge compartment	1795:1825	the scaffold sponge compartment	1795:1825	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	1	25	theme	tissue-epithelial	135:151	arg1	types					126:130	two different types	112:130	two different types of tissue-epithelial and connective (mesenchymal)	112:180	The skin is a combination of two different types of tissue-epithelial and connective (mesenchymal).
33245048	7	26	theme	average	1608:1614	arg1	size					1621:1624	an average pore size	1605:1624	an average pore size ranging from 60 to 300 μm, and sufficient tensile strength (3.12-5.26 MPa)	1605:1699	By manipulating the SA/CL/FG ratio we managed to obtain sponge scaffolds with highly interconnected porous structures, with an average pore size ranging from 60 to 300 μm, and sufficient tensile strength (3.12-5.26 MPa).
33245048	4	27	theme	cell	1050:1053	arg1	activity					1055:1062	appropriate fibroblast and multipotent stromal cell activity	1003:1062	appropriate fibroblast and multipotent stromal cell activity	1003:1062	Therefore, we developed a procedure to obtain biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation).
33245048	1	28	theme	connective	157:166	arg1	types					126:130	two different types	112:130	two different types of tissue-epithelial and connective (mesenchymal)	112:180	The skin is a combination of two different types of tissue-epithelial and connective (mesenchymal).
33245048	9	29	theme	biological	2062:2071	arg1	properties					2088:2097	biological and mechanical properties	2062:2097	biological and mechanical properties comparable with CL scaffolds	2062:2126	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	6	30	theme	slow	1370:1373	arg1	rates					1375:1379	The slow rates	1366:1379	The slow rates of composite SA-based scaffold biodegradation	1366:1425	The slow rates of composite SA-based scaffold biodegradation were achieved by using Ba2+ as cross-linking cations.
33245048	8	31	theme	primary	1832:1838	arg1	fibroblasts					1845:1855	primary skin fibroblasts	1832:1855	primary skin fibroblasts	1832:1855	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	4	32	theme	fibroblast	1015:1024	arg1	activity					1055:1062	appropriate fibroblast and multipotent stromal cell activity	1003:1062	appropriate fibroblast and multipotent stromal cell activity	1003:1062	Therefore, we developed a procedure to obtain biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation).
33245048	9	33	theme	mechanical	2077:2086	arg1	properties					2088:2097	biological and mechanical properties	2062:2097	biological and mechanical properties comparable with CL scaffolds	2062:2126	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	9	34	theme	cost	2148:2151	arg1	efficiency					2153:2162	cost efficiency	2148:2162	cost efficiency	2148:2162	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	5	35	theme	sodium	1164:1169	arg1	component					1239:1247	a base component	1232:1247	a base component for these scaffolds	1232:1267	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	35	theme	sodium	1164:1169	arg1	SA					1181:1182	SA	1181:1182	SA	1181:1182	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	35	theme	sodium	1164:1169	arg1	alginate					1171:1178	The sodium alginate	1160:1178	The sodium alginate (SA)	1160:1183	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	35	theme	sodium	1164:1169	arg1	biopolymer					1203:1212	an algae-derived biopolymer	1186:1212	an algae-derived biopolymer	1186:1212	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	9	36	theme	comparable	2099:2108	arg1	properties					2088:2097	biological and mechanical properties	2062:2097	biological and mechanical properties comparable with CL scaffolds	2062:2126	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	0	37	theme	Sodium	0:5	arg1	composites					22:31	Sodium alginate-based composites	0:31	Sodium alginate-based composites as a collagen	0:45	Sodium alginate-based composites as a collagen substitute for skin bioengineering.
33245048	8	38	theme	subcutaneous	1861:1872	arg1	cells					1898:1902	subcutaneous adipose-derived stromal cells	1861:1902	subcutaneous adipose-derived stromal cells	1861:1902	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	9	39	theme	CL	2115:2116	arg1	scaffolds					2118:2126	CL scaffolds	2115:2126	CL scaffolds	2115:2126	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	2	40	theme	fibrous	403:409	arg1	matrix					425:430	a well-vascularized fibrous extracellular matrix	383:430	a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells	383:489	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	7	41	theme	sufficient	1657:1666	arg1	strength					1676:1683	sufficient tensile strength	1657:1683	sufficient tensile strength (3.12-5.26 MPa)	1657:1699	By manipulating the SA/CL/FG ratio we managed to obtain sponge scaffolds with highly interconnected porous structures, with an average pore size ranging from 60 to 300 μm, and sufficient tensile strength (3.12-5.26 MPa).
33245048	7	41	theme	sufficient	1657:1666	arg1	MPa					1696:1698	3.12-5.26 MPa	1686:1698	3.12-5.26 MPa	1686:1698	By manipulating the SA/CL/FG ratio we managed to obtain sponge scaffolds with highly interconnected porous structures, with an average pore size ranging from 60 to 300 μm, and sufficient tensile strength (3.12-5.26 MPa).
33245048	2	42	theme	mesenchymal	465:475	arg1	cells					485:489	mesenchymal stromal cells	465:489	mesenchymal stromal cells	465:489	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	5	43	theme	minor	1322:1326	arg1	fibrinogen					1293:1302	fibrinogen	1293:1302	fibrinogen (FG)	1293:1307	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	43	theme	minor	1322:1326	arg1	additives					1328:1336	minor additives	1322:1336	minor additives in variable concentrations	1322:1363	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	43	theme	minor	1322:1326	arg1	collagen					1275:1282	collagen	1275:1282	collagen (CL)	1275:1287	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	0	44	theme	skin	62:65	arg1	bioengineering					67:80	skin bioengineering	62:80	skin bioengineering	62:80	Sodium alginate-based composites as a collagen substitute for skin bioengineering.
33245048	6	45	theme	biodegradation	1412:1425	arg1	rates					1375:1379	The slow rates	1366:1379	The slow rates of composite SA-based scaffold biodegradation	1366:1425	The slow rates of composite SA-based scaffold biodegradation were achieved by using Ba2+ as cross-linking cations.
33245048	5	46	used	used	1224:1227	arg2	SA					1181:1182	SA	1181:1182	SA	1181:1182	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	46	used	used	1224:1227	arg2	biopolymer					1203:1212	an algae-derived biopolymer	1186:1212	an algae-derived biopolymer	1186:1212	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	46	used	used	1224:1227	arg2	alginate					1171:1178	The sodium alginate	1160:1178	The sodium alginate (SA)	1160:1183	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	46	used	used	1224:1227	arg2	component					1239:1247	a base component	1232:1247	a base component for these scaffolds	1232:1267	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	2	47	theme	underlying	346:355	arg1	dermis					357:362	the underlying dermis	342:362	the underlying dermis	342:362	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	4	48	theme	keratinocyte	1106:1117	arg1	attachment					1119:1128	keratinocyte attachment	1106:1128	keratinocyte attachment	1106:1128	Therefore, we developed a procedure to obtain biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation).
33245048	8	49	theme	stromal	1890:1896	arg1	cells					1898:1902	subcutaneous adipose-derived stromal cells	1861:1902	subcutaneous adipose-derived stromal cells	1861:1902	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	3	50	theme	skin	498:501	arg1	features					503:510	These skin features	492:510	These skin features	492:510	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	4	51	theme	composite	906:914	arg1	scaffolds					924:932	biocompatible composite bilayer scaffolds	892:932	biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation)	892:1157	Therefore, we developed a procedure to obtain biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation).
33245048	9	52	theme	implantation	2212:2223	arg1	model					2225:2229	the subcutaneous implantation model	2195:2229	the subcutaneous implantation model in laboratory mice	2195:2248	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	8	53	theme	film	1914:1917	arg1	biocompatibility					1924:1939	the film side biocompatibility	1910:1939	the film side biocompatibility	1910:1939	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	2	54	theme	multiple	250:257	arg1	layers					259:264	multiple layers	250:264	multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells	250:489	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	4	55	theme	stromal	1042:1048	arg1	cell					1050:1053	multipotent stromal cell	1030:1053	multipotent stromal cell	1030:1053	Therefore, we developed a procedure to obtain biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation).
33245048	4	56	dep	film-like	1078:1086	arg1	cover					1088:1092	cover	1088:1092	cover	1088:1092	Therefore, we developed a procedure to obtain biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation).
33245048	9	57	theme	laboratory	2234:2243	arg1	mice					2245:2248	laboratory mice	2234:2248	laboratory mice	2234:2248	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	3	58	theme	scaffold	573:580	arg1	approach					721:728	a reasonable approach	708:728	a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment	708:843	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	3	58	theme	scaffold	573:580	arg1	sufficient					652:661	sufficient	652:661	sufficient	652:661	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	3	58	theme	scaffold	573:580	arg1	development					529:539	the development	525:539	the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane	525:645	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	3	59	theme	skin	771:774	arg1	generation					737:746	the generation	733:746	the generation of clinically-relevant skin	733:774	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	3	60	theme	fibroblast-friendly	546:564	arg1	scaffold					573:580	a fibroblast-friendly porous scaffold	544:580	a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane	544:645	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	4	61	theme	dermis-like	954:964	arg1	body					966:969	a spongy dermis-like body	945:969	a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation)	945:1157	Therefore, we developed a procedure to obtain biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation).
33245048	9	62	with	comparable	2099:2108	arg1	scaffolds					2118:2126	CL scaffolds	2115:2126	CL scaffolds	2115:2126	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	8	63	theme	primary	1958:1964	arg1	keratinocytes					1972:1984	primary human keratinocytes	1958:1984	primary human keratinocytes	1958:1984	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	3	64	theme	flat	597:600	arg1	sheath					608:613	a flat dense sheath	595:613	a flat dense sheath mimicking the basement membrane	595:645	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	8	65	theme	human	1748:1752	arg1	types					1764:1768	the major human skin cell types	1738:1768	the major human skin cell types	1738:1768	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	9	66	theme	obtained	1991:1998	arg1	results					2000:2006	The obtained results	1987:2006	The obtained results	1987:2006	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	3	67	theme	reconstructive	799:812	arg1	dermatology					814:824	reconstructive dermatology and burn treatment	799:843	dermatology	814:824	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	8	68	theme	cell	1759:1762	arg1	types					1764:1768	the major human skin cell types	1738:1768	the major human skin cell types	1738:1768	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	2	69	theme	protective	193:202	arg1	epidermis					227:235	the epidermis	223:235	the epidermis	223:235	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	2	69	theme	protective	193:202	arg1	layer					204:208	The outer protective layer	183:208	The outer protective layer of the skin	183:220	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	1	70	theme	different	116:124	arg1	types					126:130	two different types	112:130	two different types of tissue-epithelial and connective (mesenchymal)	112:180	The skin is a combination of two different types of tissue-epithelial and connective (mesenchymal).
33245048	7	71	theme	pore	1616:1619	arg1	size					1621:1624	an average pore size	1605:1624	an average pore size ranging from 60 to 300 μm, and sufficient tensile strength (3.12-5.26 MPa)	1605:1699	By manipulating the SA/CL/FG ratio we managed to obtain sponge scaffolds with highly interconnected porous structures, with an average pore size ranging from 60 to 300 μm, and sufficient tensile strength (3.12-5.26 MPa).
33245048	5	72	link	algae-derived	1189:1201	arg1	biopolymer					1203:1212	an algae-derived biopolymer	1186:1212	an algae-derived biopolymer	1186:1212	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	72	link	algae-derived	1189:1201	arg1	alginate					1171:1178	The sodium alginate	1160:1178	The sodium alginate (SA)	1160:1183	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	6	73	theme	scaffold	1403:1410	arg1	biodegradation					1412:1425	composite SA-based scaffold biodegradation	1384:1425	composite SA-based scaffold biodegradation	1384:1425	The slow rates of composite SA-based scaffold biodegradation were achieved by using Ba2+ as cross-linking cations.
33245048	8	74	link	adipose-derived	1874:1888	arg1	cells					1898:1902	subcutaneous adipose-derived stromal cells	1861:1902	subcutaneous adipose-derived stromal cells	1861:1902	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	9	75	theme	alginate-based	2032:2045	arg1	scaffolds					2047:2055	bilayer alginate-based scaffolds	2024:2055	bilayer alginate-based scaffolds	2024:2055	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	9	76	contain	have	2057:2060	arg2	properties					2088:2097	biological and mechanical properties	2062:2097	biological and mechanical properties comparable with CL scaffolds	2062:2126	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	9	76	contain	have	2057:2060	arg1	scaffolds					2047:2055	bilayer alginate-based scaffolds	2024:2055	bilayer alginate-based scaffolds	2024:2055	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	6	77	theme	composite	1384:1392	arg1	biodegradation					1412:1425	composite SA-based scaffold biodegradation	1384:1425	composite SA-based scaffold biodegradation	1384:1425	The slow rates of composite SA-based scaffold biodegradation were achieved by using Ba2+ as cross-linking cations.
33245048	2	78	theme	stromal	477:483	arg1	cells					485:489	mesenchymal stromal cells	465:489	mesenchymal stromal cells	465:489	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	8	79	with	biocompatibility	1716:1731	arg1	types					1764:1768	the major human skin cell types	1738:1768	the major human skin cell types	1738:1768	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	8	80	theme	sponge	1808:1813	arg1	compartment					1815:1825	the scaffold sponge compartment	1795:1825	the scaffold sponge compartment	1795:1825	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	2	81	theme	keratinocytes	269:281	arg1	layers					259:264	multiple layers	250:264	multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells	250:489	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	7	82	theme	porous	1581:1586	arg1	structures					1588:1597	highly interconnected porous structures	1559:1597	highly interconnected porous structures	1559:1597	By manipulating the SA/CL/FG ratio we managed to obtain sponge scaffolds with highly interconnected porous structures, with an average pore size ranging from 60 to 300 μm, and sufficient tensile strength (3.12-5.26 MPa).
33245048	5	83	used	used	1314:1317	arg2	collagen					1275:1282	collagen	1275:1282	collagen (CL)	1275:1287	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	83	used	used	1314:1317	arg2	FG					1305:1306	FG	1305:1306	FG	1305:1306	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	83	used	used	1314:1317	arg2	fibrinogen					1293:1302	fibrinogen	1293:1302	fibrinogen (FG)	1293:1307	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	83	used	used	1314:1317	arg2	CL					1285:1286	CL	1285:1286	CL	1285:1286	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	83	used	used	1314:1317	arg2	additives					1328:1336	minor additives	1322:1336	minor additives in variable concentrations	1322:1363	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	4	84	theme	appropriate	1003:1013	arg1	fibroblast					1015:1024	appropriate fibroblast	1003:1024	appropriate fibroblast	1003:1024	Therefore, we developed a procedure to obtain biocompatible composite bilayer scaffolds comprising a spongy dermis-like body (supporting vascularization and appropriate fibroblast and multipotent stromal cell activity) fused with a film-like cover (supporting keratinocyte attachment, growth and differentiation).
33245048	5	85	theme	variable	1341:1348	arg1	concentrations					1350:1363	variable concentrations	1341:1363	variable concentrations	1341:1363	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	0	86	theme	alginate-based	7:20	arg1	composites					22:31	Sodium alginate-based composites	0:31	Sodium alginate-based composites as a collagen	0:45	Sodium alginate-based composites as a collagen substitute for skin bioengineering.
33245048	8	87	theme	skin	1840:1843	arg1	fibroblasts					1845:1855	primary skin fibroblasts	1832:1855	primary skin fibroblasts	1832:1855	The scaffolds biocompatibility with the major human skin cell types was confirmed by seeding the scaffold sponge compartment with primary skin fibroblasts and subcutaneous adipose-derived stromal cells while the film side biocompatibility was tested using primary human keratinocytes.
33245048	2	88	theme	extracellular	411:423	arg1	matrix					425:430	a well-vascularized fibrous extracellular matrix	383:430	a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells	383:489	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	1	89	dep	tissue-epithelial	135:151	arg1	mesenchymal					169:179	mesenchymal	169:179	mesenchymal	169:179	The skin is a combination of two different types of tissue-epithelial and connective (mesenchymal).
33245048	2	90	theme	well-vascularized	385:401	arg1	matrix					425:430	a well-vascularized fibrous extracellular matrix	383:430	a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells	383:489	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	7	91	theme	interconnected	1566:1579	arg1	structures					1588:1597	highly interconnected porous structures	1559:1597	highly interconnected porous structures	1559:1597	By manipulating the SA/CL/FG ratio we managed to obtain sponge scaffolds with highly interconnected porous structures, with an average pore size ranging from 60 to 300 μm, and sufficient tensile strength (3.12-5.26 MPa).
33245048	7	92	theme	tensile	1668:1674	arg1	strength					1676:1683	sufficient tensile strength	1657:1683	sufficient tensile strength (3.12-5.26 MPa)	1657:1699	By manipulating the SA/CL/FG ratio we managed to obtain sponge scaffolds with highly interconnected porous structures, with an average pore size ranging from 60 to 300 μm, and sufficient tensile strength (3.12-5.26 MPa).
33245048	7	92	theme	tensile	1668:1674	arg1	MPa					1696:1698	3.12-5.26 MPa	1686:1698	3.12-5.26 MPa	1686:1698	By manipulating the SA/CL/FG ratio we managed to obtain sponge scaffolds with highly interconnected porous structures, with an average pore size ranging from 60 to 300 μm, and sufficient tensile strength (3.12-5.26 MPa).
33245048	9	93	from	model	2225:2229	arg1	mice					2245:2248	laboratory mice	2234:2248	laboratory mice	2234:2248	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	5	94	theme	algae-derived	1189:1201	arg1	biopolymer					1203:1212	an algae-derived biopolymer	1186:1212	an algae-derived biopolymer	1186:1212	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	5	94	theme	algae-derived	1189:1201	arg1	alginate					1171:1178	The sodium alginate	1160:1178	The sodium alginate (SA)	1160:1183	The sodium alginate (SA), an algae-derived biopolymer, has been used as a base component for these scaffolds while collagen (CL) and fibrinogen (FG) were used as minor additives in variable concentrations.
33245048	3	95	theme	keratinocyte	674:685	arg1	attachment					687:696	keratinocyte attachment	674:696	keratinocyte attachment	674:696	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	7	96	theme	sponge	1537:1542	arg1	scaffolds					1544:1552	sponge scaffolds	1537:1552	sponge scaffolds	1537:1552	By manipulating the SA/CL/FG ratio we managed to obtain sponge scaffolds with highly interconnected porous structures, with an average pore size ranging from 60 to 300 μm, and sufficient tensile strength (3.12-5.26 MPa).
33245048	3	97	theme	dense	602:606	arg1	sheath					608:613	a flat dense sheath	595:613	a flat dense sheath mimicking the basement membrane	595:645	These skin features suggest that the development of a fibroblast-friendly porous scaffold covered with a flat dense sheath mimicking the basement membrane, and sufficient to support keratinocyte attachment, would be a reasonable approach in the generation of clinically-relevant skin substitutes useful for reconstructive dermatology and burn treatment.
33245048	2	98	theme	outer	187:191	arg1	epidermis					227:235	the epidermis	223:235	the epidermis	223:235	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	2	98	theme	outer	187:191	arg1	layer					204:208	The outer protective layer	183:208	The outer protective layer of the skin	183:220	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	2	99	theme	basement	299:306	arg1	membrane					308:315	the basement membrane	295:315	the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells	295:489	The outer protective layer of the skin, the epidermis, consists of multiple layers of keratinocytes residing on the basement membrane that separates them from the underlying dermis, which consists of a well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts and mesenchymal stromal cells.
33245048	9	100	theme	vascularization	2168:2182	arg1	ability					2184:2190	vascularization ability	2168:2190	vascularization ability	2168:2190	The obtained results have shown that bilayer alginate-based scaffolds have biological and mechanical properties comparable with CL scaffolds but surpass them in cost efficiency and vascularization ability in the subcutaneous implantation model in laboratory mice.
33245048	6	101	theme	cross-linking	1458:1470	arg1	Ba2+					1450:1453	Ba2+	1450:1453	Ba2+	1450:1453	The slow rates of composite SA-based scaffold biodegradation were achieved by using Ba2+ as cross-linking cations.
33245048	6	101	theme	cross-linking	1458:1470	arg1	cations					1472:1478	cross-linking cations	1458:1478	cross-linking cations	1458:1478	The slow rates of composite SA-based scaffold biodegradation were achieved by using Ba2+ as cross-linking cations.
32182495	1	0	theme	atom	699:702	arg1	%					703:703	4.3 atom% and 10.66 atom%	695:719	%	703:703	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	3	1	theme	apparent	926:933	arg1	constant					948:955	the apparent kinetic rate constant	922:955	the apparent kinetic rate constant	922:955	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	3	1	theme	apparent	926:933	arg1	0.0394 min-1					975:986	0.0394 min-1	975:986	0.0394 min-1	975:986	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	1	2	dep	800 °C	490:495	arg1	applied					583:589	applied	583:589	have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively	573:733	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	5	3	theme	new	1165:1167	arg1	possibilities					1169:1181	new possibilities	1165:1181	new possibilities of valorization for cellulose-based by-product and treatment of p-NP-based wastewater	1165:1267	These findings open up new possibilities of valorization for cellulose-based by-product and treatment of p-NP-based wastewater.
32182495	1	4	theme	%	703:703	arg1	levels					685:690	doping levels	678:690	doping levels of 4.3 atom% and 10.66 atom%, respectively	678:733	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	5	dep	nitrogen	271:278	arg1	catalysts					328:336	co-doped carbon-based metal-free catalysts	295:336	co-doped carbon-based metal-free catalysts	295:336	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	6	dep	N	670:670	arg1	levels					685:690	doping levels	678:690	doping levels of 4.3 atom% and 10.66 atom%, respectively	678:733	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	4	7	theme	experimental	1120:1131	arg1	results					1133:1139	the experimental results	1116:1139	the experimental results	1116:1139	The catalytic mechanism is proposed by combining the density functional theory calculation and analysis of the experimental results.
32182495	1	8	theme	abundant	156:163	arg1	by-products					171:181	the most abundant solid by-products	147:181	the most abundant solid by-products of agriculture and forestry industry	147:218	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	2	9	theme	p-nitrophenol	803:815	arg1	reduction					790:798	the reduction	786:798	the reduction of p-nitrophenol (p-NP)	786:822	The NPC exhibits excellent catalytic activity for the reduction of p-nitrophenol (p-NP).
32182495	4	10	theme	results	1133:1139	arg1	analysis					1104:1111	analysis	1104:1111	analysis of the experimental results	1104:1139	The catalytic mechanism is proposed by combining the density functional theory calculation and analysis of the experimental results.
32182495	4	10	theme	results	1133:1139	arg1	calculation					1088:1098	the density functional theory calculation	1058:1098	the density functional theory calculation	1058:1098	The catalytic mechanism is proposed by combining the density functional theory calculation and analysis of the experimental results.
32182495	0	11	theme	p-nitrophenol	101:113	arg1	reduction					88:96	catalytic reduction	78:96	catalytic reduction of p-nitrophenol	78:113	Cellulose derived nitrogen and phosphorus co-doped carbon-based catalysts for catalytic reduction of p-nitrophenol.
32182495	1	12	theme	hydrogel	452:459	arg1	annealing					435:443	annealing	435:443	annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively	435:733	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	4	13	theme	theory	1081:1086	arg1	calculation					1088:1098	the density functional theory calculation	1058:1098	the density functional theory calculation	1058:1098	The catalytic mechanism is proposed by combining the density functional theory calculation and analysis of the experimental results.
32182495	3	14	theme	reduction	861:869	arg1	TOF					849:851	TOF	849:851	TOF	849:851	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	3	14	theme	reduction	861:869	arg1	frequency					838:846	The turnover frequency	825:846	The turnover frequency (TOF) of the reduction of p-NP	825:877	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	3	14	theme	reduction	861:869	arg1	high					885:888	high	885:888	high	885:888	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	5	15	theme	valorization	1186:1197	arg1	possibilities					1169:1181	new possibilities	1165:1181	new possibilities of valorization for cellulose-based by-product and treatment of p-NP-based wastewater	1165:1267	These findings open up new possibilities of valorization for cellulose-based by-product and treatment of p-NP-based wastewater.
32182495	1	16	theme	atom	715:718	arg1	%					719:719	4.3 atom% and 10.66 atom%	695:719	%	719:719	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	5	17	theme	wastewater	1258:1267	arg1	treatment					1234:1242	treatment	1234:1242	treatment	1234:1242	These findings open up new possibilities of valorization for cellulose-based by-product and treatment of p-NP-based wastewater.
32182495	5	17	theme	wastewater	1258:1267	arg1	by-product					1219:1228	cellulose-based by-product	1203:1228	cellulose-based by-product	1203:1228	These findings open up new possibilities of valorization for cellulose-based by-product and treatment of p-NP-based wastewater.
32182495	1	18	theme	FTIR	547:550	arg1	TEM					537:539	TEM	537:539	TEM	537:539	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	18	theme	FTIR	547:550	arg1	spectroscopy					560:571	FTIR and XPS spectroscopy	547:571	spectroscopy	560:571	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	19	theme	solid	165:169	arg1	by-products					171:181	the most abundant solid by-products	147:181	the most abundant solid by-products of agriculture and forestry industry	147:218	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	20	theme	%	719:719	arg1	levels					685:690	doping levels	678:690	doping levels of 4.3 atom% and 10.66 atom%, respectively	678:733	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	21	theme	nitrogen	467:474	arg1	atmosphere					476:485	nitrogen atmosphere	467:485	nitrogen atmosphere	467:485	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	22	theme	by-products	171:181	arg1	one					140:142	one	140:142	one	140:142	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	22	theme	by-products	171:181	arg1	by-products					171:181	the most abundant solid by-products	147:181	the most abundant solid by-products of agriculture and forestry industry	147:218	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	22	theme	by-products	171:181	arg1	cellulose					120:128	The cellulose	116:128	The cellulose	116:128	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	23	theme	flake-like	643:652	arg1	morphology					654:663	flake-like morphology	643:663	flake-like morphology	643:663	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	24	theme	cellulose	377:385	arg1	crystallite					387:397	cellulose crystallite	377:397	cellulose crystallite	377:397	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	25	theme	XPS	556:558	arg1	TEM					537:539	TEM	537:539	TEM	537:539	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	25	theme	XPS	556:558	arg1	spectroscopy					560:571	FTIR and XPS spectroscopy	547:571	spectroscopy	560:571	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	26	theme	nitrogen	271:278	arg1	synthesis					258:266	the synthesis	254:266	the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively	254:733	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	2	27	theme	catalytic	763:771	arg1	activity					773:780	excellent catalytic activity	753:780	excellent catalytic activity for the reduction of p-nitrophenol (p-NP)	753:822	The NPC exhibits excellent catalytic activity for the reduction of p-nitrophenol (p-NP).
32182495	1	28	theme	agriculture	186:196	arg1	by-products					171:181	the most abundant solid by-products	147:181	the most abundant solid by-products of agriculture and forestry industry	147:218	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	2	29	theme	excellent	753:761	arg1	activity					773:780	excellent catalytic activity	753:780	excellent catalytic activity for the reduction of p-nitrophenol (p-NP)	753:822	The NPC exhibits excellent catalytic activity for the reduction of p-nitrophenol (p-NP).
32182495	0	30	theme	nitrogen	18:25	arg1	catalysts					64:72	nitrogen and phosphorus co-doped carbon-based catalysts	18:72	nitrogen and phosphorus co-doped carbon-based catalysts	18:72	Cellulose derived nitrogen and phosphorus co-doped carbon-based catalysts for catalytic reduction of p-nitrophenol.
32182495	1	31	theme	phosphorus	284:293	arg1	synthesis					258:266	the synthesis	254:266	the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively	254:733	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	32	theme	crystallite	387:397	arg1	mixture					366:372	the mixture	362:372	the mixture	362:372	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	3	33	theme	p-NP	874:877	arg1	reduction					861:869	the reduction	857:869	the reduction of p-NP	857:877	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	1	34	theme	forestry	202:209	arg1	industry					211:218	forestry industry	202:218	forestry industry	202:218	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	0	35	theme	co-doped	42:49	arg1	catalysts					64:72	nitrogen and phosphorus co-doped carbon-based catalysts	18:72	nitrogen and phosphorus co-doped carbon-based catalysts	18:72	Cellulose derived nitrogen and phosphorus co-doped carbon-based catalysts for catalytic reduction of p-nitrophenol.
32182495	1	36	theme	co-doped	295:302	arg1	catalysts					328:336	co-doped carbon-based metal-free catalysts	295:336	co-doped carbon-based metal-free catalysts	295:336	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	5	37	theme	p-NP-based	1247:1256	arg1	wastewater					1258:1267	p-NP-based wastewater	1247:1267	p-NP-based wastewater	1247:1267	These findings open up new possibilities of valorization for cellulose-based by-product and treatment of p-NP-based wastewater.
32182495	4	38	theme	functional	1070:1079	arg1	calculation					1088:1098	the density functional theory calculation	1058:1098	the density functional theory calculation	1058:1098	The catalytic mechanism is proposed by combining the density functional theory calculation and analysis of the experimental results.
32182495	1	39	theme	industry	211:218	arg1	by-products					171:181	the most abundant solid by-products	147:181	the most abundant solid by-products of agriculture and forestry industry	147:218	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	0	40	theme	phosphorus	31:40	arg1	catalysts					64:72	nitrogen and phosphorus co-doped carbon-based catalysts	18:72	nitrogen and phosphorus co-doped carbon-based catalysts	18:72	Cellulose derived nitrogen and phosphorus co-doped carbon-based catalysts for catalytic reduction of p-nitrophenol.
32182495	1	41	theme	carbon-based	304:315	arg1	catalysts					328:336	co-doped carbon-based metal-free catalysts	295:336	co-doped carbon-based metal-free catalysts	295:336	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	42	theme	ammonium	403:410	arg1	phosphate					412:420	ammonium phosphate	403:420	ammonium phosphate	403:420	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	43	theme	doping	678:683	arg1	levels					685:690	doping levels	678:690	doping levels of 4.3 atom% and 10.66 atom%, respectively	678:733	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	44	theme	metal-free	317:326	arg1	catalysts					328:336	co-doped carbon-based metal-free catalysts	295:336	co-doped carbon-based metal-free catalysts	295:336	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	45	theme	phosphate	412:420	arg1	mixture					366:372	the mixture	362:372	the mixture	362:372	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	46	theme	2 h.	501:504	arg1	TEM					537:539	TEM	537:539	TEM	537:539	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	46	theme	2 h.	501:504	arg1	techniques					516:525	2 h. Different techniques	501:525	2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy	501:571	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	0	47	theme	carbon-based	51:62	arg1	catalysts					64:72	nitrogen and phosphorus co-doped carbon-based catalysts	18:72	nitrogen and phosphorus co-doped carbon-based catalysts	18:72	Cellulose derived nitrogen and phosphorus co-doped carbon-based catalysts for catalytic reduction of p-nitrophenol.
32182495	1	48	theme	Different	506:514	arg1	TEM					537:539	TEM	537:539	TEM	537:539	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	48	theme	Different	506:514	arg1	techniques					516:525	2 h. Different techniques	501:525	2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy	501:571	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	49	from	800 °C	490:495	arg1	hydrogel					452:459	the hydrogel	448:459	the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively	448:733	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	49	from	800 °C	490:495	arg1	annealing					435:443	annealing	435:443	annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively	435:733	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	3	50	theme	room	991:994	arg1	temperature					996:1006	room temperature	991:1006	room temperature	991:1006	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	3	51	theme	turnover	829:836	arg1	TOF					849:851	TOF	849:851	TOF	849:851	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	3	51	theme	turnover	829:836	arg1	frequency					838:846	The turnover frequency	825:846	The turnover frequency (TOF) of the reduction of p-NP	825:877	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	3	51	theme	turnover	829:836	arg1	high					885:888	high	885:888	high	885:888	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	3	52	theme	kinetic	935:941	arg1	constant					948:955	the apparent kinetic rate constant	922:955	the apparent kinetic rate constant	922:955	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	3	52	theme	kinetic	935:941	arg1	0.0394 min-1					975:986	0.0394 min-1	975:986	0.0394 min-1	975:986	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	5	53	theme	cellulose-based	1203:1217	arg1	by-product					1219:1228	cellulose-based by-product	1203:1228	cellulose-based by-product	1203:1228	These findings open up new possibilities of valorization for cellulose-based by-product and treatment of p-NP-based wastewater.
32182495	0	54	theme	catalytic	78:86	arg1	reduction					88:96	catalytic reduction	78:96	catalytic reduction of p-nitrophenol	78:113	Cellulose derived nitrogen and phosphorus co-doped carbon-based catalysts for catalytic reduction of p-nitrophenol.
32182495	4	55	theme	catalytic	1013:1021	arg1	mechanism					1023:1031	The catalytic mechanism	1009:1031	The catalytic mechanism	1009:1031	The catalytic mechanism is proposed by combining the density functional theory calculation and analysis of the experimental results.
32182495	3	56	theme	rate	943:946	arg1	constant					948:955	the apparent kinetic rate constant	922:955	the apparent kinetic rate constant	922:955	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	3	56	theme	rate	943:946	arg1	0.0394 min-1					975:986	0.0394 min-1	975:986	0.0394 min-1	975:986	The turnover frequency (TOF) of the reduction of p-NP is as high as 2 × 10-5 mmol·mg-1·min-1 and the apparent kinetic rate constant was calculated as 0.0394 min-1 at room temperature.
32182495	1	57	theme	as-prepared	611:621	arg1	NPC					623:625	the as-prepared NPC	607:625	the as-prepared NPC	607:625	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	1	58	from	annealing	435:443	arg1	800 °C					490:495	800 °C	490:495	800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively	490:733	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
32182495	4	59	theme	density	1062:1068	arg1	calculation					1088:1098	the density functional theory calculation	1058:1098	the density functional theory calculation	1058:1098	The catalytic mechanism is proposed by combining the density functional theory calculation and analysis of the experimental results.
32182495	1	60	theme	10.66	709:713	arg1	%					719:719	4.3 atom% and 10.66 atom%	695:719	%	719:719	The cellulose, which is one of the most abundant solid by-products of agriculture and forestry industry, has been successfully tested for the synthesis of nitrogen and phosphorus co-doped carbon-based metal-free catalysts (NPC) via freeze-drying the mixture of cellulose crystallite and ammonium phosphate, followed by annealing of the hydrogel under nitrogen atmosphere at 800 °C for 2 h. Different techniques including TEM, SEM, FTIR and XPS spectroscopy have been applied to characterize the as-prepared NPC, which presents flake-like morphology with N and P doping levels of 4.3 atom% and 10.66 atom%, respectively.
33656347	0	0	theme	Enhanced	85:92	arg1	Systems					103:109	Enhanced Delivery Systems	85:109	Enhanced Delivery Systems	85:109	In-Depth Study of Cyclodextrin Complexation with Carotenoids toward the Formation of Enhanced Delivery Systems.
33656347	5	1	with	βCD	874:876	arg1	contents					905:912	three different water contents	883:912	three different water contents	883:912	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	8	2	theme	studied	1352:1358	arg1	similar					1403:1409	similar	1403:1409	similar	1403:1409	This is due to the fact that all the CD faces are exhibiting similar chemical compositions, the three studied carotenoid molecules are rather chemically similar, and last, the water-carotenoid interactions appear to be weak compared to the CD-carotenoid interactions.
33656347	8	2	theme	studied	1352:1358	arg1	molecules					1371:1379	the three studied carotenoid molecules	1342:1379	the three studied carotenoid molecules	1342:1379	This is due to the fact that all the CD faces are exhibiting similar chemical compositions, the three studied carotenoid molecules are rather chemically similar, and last, the water-carotenoid interactions appear to be weak compared to the CD-carotenoid interactions.
33656347	5	3	theme	different	889:897	arg1	contents					905:912	three different water contents	883:912	three different water contents	883:912	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	8	4	theme	water-carotenoid	1426:1441	arg1	weak					1469:1472	weak	1469:1472	weak	1469:1472	This is due to the fact that all the CD faces are exhibiting similar chemical compositions, the three studied carotenoid molecules are rather chemically similar, and last, the water-carotenoid interactions appear to be weak compared to the CD-carotenoid interactions.
33656347	8	4	theme	water-carotenoid	1426:1441	arg1	interactions					1443:1454	the water-carotenoid interactions	1422:1454	the water-carotenoid interactions	1422:1454	This is due to the fact that all the CD faces are exhibiting similar chemical compositions, the three studied carotenoid molecules are rather chemically similar, and last, the water-carotenoid interactions appear to be weak compared to the CD-carotenoid interactions.
33656347	3	5	from	molecules	506:514	arg1	complexes					478:486	complexes	478:486	complexes from dispersed CD molecules	478:514	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	5	from	molecules	506:514	arg1	formation					465:473	the formation	461:473	the formation of complexes from dispersed CD molecules	461:514	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	6	dep	CDs	560:562	arg1	hydroxypropyl-βCD					587:603	hydroxypropyl-βCD	587:603	hydroxypropyl-βCD	587:603	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	6	dep	CDs	560:562	arg1	αCD					565:567	αCD	565:567	αCD	565:567	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	6	dep	CDs	560:562	arg1	βCD					570:572	βCD	570:572	βCD	570:572	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	6	dep	CDs	560:562	arg1	γCD					610:612	γCD	610:612	γCD	610:612	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	6	dep	CDs	560:562	arg1	CDs					560:562	five different CDs	545:562	five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD)	545:613	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	6	dep	CDs	560:562	arg1	methyl-βCD					575:584	methyl-βCD	575:584	methyl-βCD	575:584	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	0	7	theme	Systems	103:109	arg1	Formation					72:80	the Formation	68:80	the Formation of Enhanced Delivery Systems	68:109	In-Depth Study of Cyclodextrin Complexation with Carotenoids toward the Formation of Enhanced Delivery Systems.
33656347	0	8	theme	Delivery	94:101	arg1	Systems					103:109	Enhanced Delivery Systems	85:109	Enhanced Delivery Systems	85:109	In-Depth Study of Cyclodextrin Complexation with Carotenoids toward the Formation of Enhanced Delivery Systems.
33656347	5	9	theme	carotenoid	940:949	arg1	lycopene					970:977	lycopene	970:977	lycopene	970:977	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	5	9	theme	carotenoid	940:949	arg1	β-carotene					984:993	β-carotene	984:993	β-carotene	984:993	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	5	9	theme	carotenoid	940:949	arg1	lutein					962:967	lutein	962:967	lutein	962:967	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	5	9	theme	carotenoid	940:949	arg1	molecules					951:959	three carotenoid molecules	934:959	three carotenoid molecules (lutein, lycopene, and β-carotene)	934:994	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	6	10	theme	different	1079:1087	arg1	faces					1089:1093	the different faces	1075:1093	the different faces of the CD crystals	1075:1112	The docking/adsorption of the carotenoid molecules was modeled on the different faces of the CD crystals.
33656347	5	11	dep	molecules	951:959	arg1	lycopene					970:977	lycopene	970:977	lycopene	970:977	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	5	11	dep	molecules	951:959	arg1	β-carotene					984:993	β-carotene	984:993	β-carotene	984:993	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	5	11	dep	molecules	951:959	arg1	lutein					962:967	lutein	962:967	lutein	962:967	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	5	11	dep	molecules	951:959	arg1	molecules					951:959	three carotenoid molecules	934:959	three carotenoid molecules (lutein, lycopene, and β-carotene)	934:994	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	2	12	theme	complex	418:424	arg1	process					436:442	the complex formation process	414:442	the complex formation process pathways	414:451	Distinction was made between complexes resulting from interactions between carotenoids and either molecularly dispersed CDs or solid crystalline CDs, considering that both cases can occur depending on the complex formation process pathways.
33656347	5	13	theme	water	899:903	arg1	contents					905:912	three different water contents	883:912	three different water contents	883:912	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	1	14	theme	cyclodextrin	161:172	arg1	goal					116:119	The goal	112:119	The goal of this study	112:133	The goal of this study was molecular modeling of cyclodextrin (CD) and carotenoid complex formation.
33656347	1	14	theme	cyclodextrin	161:172	arg1	modeling					149:156	molecular modeling	139:156	molecular modeling of cyclodextrin (CD)	139:177	The goal of this study was molecular modeling of cyclodextrin (CD) and carotenoid complex formation.
33656347	1	14	theme	cyclodextrin	161:172	arg1	formation					202:210	carotenoid complex formation	183:210	carotenoid complex formation	183:210	The goal of this study was molecular modeling of cyclodextrin (CD) and carotenoid complex formation.
33656347	7	15	theme	CD	1151:1152	arg1	faces					1154:1158	all the CD faces	1143:1158	all the CD faces	1143:1158	The findings highlight that all the CD faces, and thus their growth rates, were equally impacted by the adsorption of the carotenoids.
33656347	3	16	theme	different	550:558	arg1	hydroxypropyl-βCD					587:603	hydroxypropyl-βCD	587:603	hydroxypropyl-βCD	587:603	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	16	theme	different	550:558	arg1	lutein					619:624	lutein	619:624	lutein	619:624	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	16	theme	different	550:558	arg1	αCD					565:567	αCD	565:567	αCD	565:567	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	16	theme	different	550:558	arg1	βCD					570:572	βCD	570:572	βCD	570:572	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	16	theme	different	550:558	arg1	γCD					610:612	γCD	610:612	γCD	610:612	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	16	theme	different	550:558	arg1	CDs					560:562	five different CDs	545:562	five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD)	545:613	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	16	theme	different	550:558	arg1	methyl-βCD					575:584	methyl-βCD	575:584	methyl-βCD	575:584	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	16	theme	different	550:558	arg1	molecule					649:656	a model carotenoid molecule	630:656	a model carotenoid molecule	630:656	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	6	17	theme	carotenoid	1039:1048	arg1	molecules					1050:1058	the carotenoid molecules	1035:1058	the carotenoid molecules	1035:1058	The docking/adsorption of the carotenoid molecules was modeled on the different faces of the CD crystals.
33656347	6	18	theme	molecules	1050:1058	arg1	docking/adsorption					1013:1030	The docking/adsorption	1009:1030	The docking/adsorption of the carotenoid molecules	1009:1058	The docking/adsorption of the carotenoid molecules was modeled on the different faces of the CD crystals.
33656347	4	19	theme	complexes	720:728	arg1	stability					693:701	the stability	689:701	the stability of the different complexes formed	689:735	The interactions involved and the stability of the different complexes formed were evaluated according to the CD size and steric hindrance.
33656347	4	19	theme	complexes	720:728	arg1	interactions					663:674	The interactions	659:674	The interactions involved	659:683	The interactions involved and the stability of the different complexes formed were evaluated according to the CD size and steric hindrance.
33656347	5	20	theme	different	847:855	arg1	βCD					874:876	βCD	874:876	βCD with three different water contents	874:912	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	5	20	theme	different	847:855	arg1	CDs					869:871	four different crystalline CDs	842:871	four different crystalline CDs (βCD with three different water contents and methyl-βCD)	842:928	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	5	20	theme	different	847:855	arg1	methyl-βCD					918:927	methyl-βCD	918:927	methyl-βCD	918:927	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	0	21	theme	In-Depth	0:7	arg1	Study					9:13	In-Depth Study	0:13	In-Depth Study of Cyclodextrin Complexation with Carotenoids toward the Formation of Enhanced Delivery Systems.	0:110	In-Depth Study of Cyclodextrin Complexation with Carotenoids toward the Formation of Enhanced Delivery Systems.
33656347	2	22	theme	dispersed	323:331	arg1	CDs					333:335	molecularly dispersed CDs	311:335	molecularly dispersed CDs	311:335	Distinction was made between complexes resulting from interactions between carotenoids and either molecularly dispersed CDs or solid crystalline CDs, considering that both cases can occur depending on the complex formation process pathways.
33656347	5	23	theme	crystalline	857:867	arg1	βCD					874:876	βCD	874:876	βCD with three different water contents	874:912	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	5	23	theme	crystalline	857:867	arg1	CDs					869:871	four different crystalline CDs	842:871	four different crystalline CDs (βCD with three different water contents and methyl-βCD)	842:928	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	5	23	theme	crystalline	857:867	arg1	methyl-βCD					918:927	methyl-βCD	918:927	methyl-βCD	918:927	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	0	24	theme	Cyclodextrin	18:29	arg1	Complexation					31:42	Cyclodextrin Complexation	18:42	Cyclodextrin Complexation	18:42	In-Depth Study of Cyclodextrin Complexation with Carotenoids toward the Formation of Enhanced Delivery Systems.
33656347	4	25	theme	different	710:718	arg1	complexes					720:728	the different complexes	706:728	the different complexes formed	706:735	The interactions involved and the stability of the different complexes formed were evaluated according to the CD size and steric hindrance.
33656347	5	26	dep	CDs	869:871	arg1	βCD					874:876	βCD	874:876	βCD with three different water contents	874:912	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	5	26	dep	CDs	869:871	arg1	CDs					869:871	four different crystalline CDs	842:871	four different crystalline CDs (βCD with three different water contents and methyl-βCD)	842:928	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	5	26	dep	CDs	869:871	arg1	methyl-βCD					918:927	methyl-βCD	918:927	methyl-βCD	918:927	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	2	27	theme	formation	426:434	arg1	process					436:442	the complex formation process	414:442	the complex formation process pathways	414:451	Distinction was made between complexes resulting from interactions between carotenoids and either molecularly dispersed CDs or solid crystalline CDs, considering that both cases can occur depending on the complex formation process pathways.
33656347	2	28	theme	process	436:442	arg1	pathways					444:451	the complex formation process pathways	414:451	the complex formation process pathways	414:451	Distinction was made between complexes resulting from interactions between carotenoids and either molecularly dispersed CDs or solid crystalline CDs, considering that both cases can occur depending on the complex formation process pathways.
33656347	3	29	from	formation	465:473	arg1	molecules					506:514	dispersed CD molecules	493:514	dispersed CD molecules	493:514	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	6	30	theme	CD	1102:1103	arg1	crystals					1105:1112	the CD crystals	1098:1112	the CD crystals	1098:1112	The docking/adsorption of the carotenoid molecules was modeled on the different faces of the CD crystals.
33656347	1	31	theme	carotenoid	183:192	arg1	formation					202:210	carotenoid complex formation	183:210	carotenoid complex formation	183:210	The goal of this study was molecular modeling of cyclodextrin (CD) and carotenoid complex formation.
33656347	2	32	theme	crystalline	346:356	arg1	CDs					358:360	solid crystalline CDs	340:360	solid crystalline CDs	340:360	Distinction was made between complexes resulting from interactions between carotenoids and either molecularly dispersed CDs or solid crystalline CDs, considering that both cases can occur depending on the complex formation process pathways.
33656347	8	33	theme	carotenoid	1360:1369	arg1	similar					1403:1409	similar	1403:1409	similar	1403:1409	This is due to the fact that all the CD faces are exhibiting similar chemical compositions, the three studied carotenoid molecules are rather chemically similar, and last, the water-carotenoid interactions appear to be weak compared to the CD-carotenoid interactions.
33656347	8	33	theme	carotenoid	1360:1369	arg1	molecules					1371:1379	the three studied carotenoid molecules	1342:1379	the three studied carotenoid molecules	1342:1379	This is due to the fact that all the CD faces are exhibiting similar chemical compositions, the three studied carotenoid molecules are rather chemically similar, and last, the water-carotenoid interactions appear to be weak compared to the CD-carotenoid interactions.
33656347	8	34	theme	similar	1311:1317	arg1	compositions					1328:1339	similar chemical compositions	1311:1339	similar chemical compositions	1311:1339	This is due to the fact that all the CD faces are exhibiting similar chemical compositions, the three studied carotenoid molecules are rather chemically similar, and last, the water-carotenoid interactions appear to be weak compared to the CD-carotenoid interactions.
33656347	1	35	theme	complex	194:200	arg1	formation					202:210	carotenoid complex formation	183:210	carotenoid complex formation	183:210	The goal of this study was molecular modeling of cyclodextrin (CD) and carotenoid complex formation.
33656347	0	36	theme	Complexation	31:42	arg1	Study					9:13	In-Depth Study	0:13	In-Depth Study of Cyclodextrin Complexation with Carotenoids toward the Formation of Enhanced Delivery Systems.	0:110	In-Depth Study of Cyclodextrin Complexation with Carotenoids toward the Formation of Enhanced Delivery Systems.
33656347	5	37	theme	complexes	824:832	arg1	formation					811:819	the formation	807:819	the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene)	807:994	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	8	38	theme	CD-carotenoid	1490:1502	arg1	interactions					1504:1515	the CD-carotenoid interactions	1486:1515	the CD-carotenoid interactions	1486:1515	This is due to the fact that all the CD faces are exhibiting similar chemical compositions, the three studied carotenoid molecules are rather chemically similar, and last, the water-carotenoid interactions appear to be weak compared to the CD-carotenoid interactions.
33656347	8	39	theme	CD	1287:1288	arg1	faces					1290:1294	all the CD faces	1279:1294	all the CD faces	1279:1294	This is due to the fact that all the CD faces are exhibiting similar chemical compositions, the three studied carotenoid molecules are rather chemically similar, and last, the water-carotenoid interactions appear to be weak compared to the CD-carotenoid interactions.
33656347	3	40	theme	dispersed	493:501	arg1	molecules					506:514	dispersed CD molecules	493:514	dispersed CD molecules	493:514	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	8	41	theme	chemical	1319:1326	arg1	compositions					1328:1339	similar chemical compositions	1311:1339	similar chemical compositions	1311:1339	This is due to the fact that all the CD faces are exhibiting similar chemical compositions, the three studied carotenoid molecules are rather chemically similar, and last, the water-carotenoid interactions appear to be weak compared to the CD-carotenoid interactions.
33656347	0	42	with	Study	9:13	arg1	Carotenoids					49:59	Carotenoids	49:59	Carotenoids toward the Formation of Enhanced Delivery Systems	49:109	In-Depth Study of Cyclodextrin Complexation with Carotenoids toward the Formation of Enhanced Delivery Systems.
33656347	3	43	theme	CD	503:504	arg1	molecules					506:514	dispersed CD molecules	493:514	dispersed CD molecules	493:514	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	2	44	theme	solid	340:344	arg1	CDs					358:360	solid crystalline CDs	340:360	solid crystalline CDs	340:360	Distinction was made between complexes resulting from interactions between carotenoids and either molecularly dispersed CDs or solid crystalline CDs, considering that both cases can occur depending on the complex formation process pathways.
33656347	6	45	theme	crystals	1105:1112	arg1	faces					1089:1093	the different faces	1075:1093	the different faces of the CD crystals	1075:1112	The docking/adsorption of the carotenoid molecules was modeled on the different faces of the CD crystals.
33656347	3	46	theme	model	632:636	arg1	CDs					560:562	five different CDs	545:562	five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD)	545:613	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	46	theme	model	632:636	arg1	lutein					619:624	lutein	619:624	lutein	619:624	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	46	theme	model	632:636	arg1	molecule					649:656	a model carotenoid molecule	630:656	a model carotenoid molecule	630:656	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	4	47	theme	CD	769:770	arg1	size					772:775	the CD size	765:775	the CD size	765:775	The interactions involved and the stability of the different complexes formed were evaluated according to the CD size and steric hindrance.
33656347	1	48	theme	study	129:133	arg1	goal					116:119	The goal	112:119	The goal of this study	112:133	The goal of this study was molecular modeling of cyclodextrin (CD) and carotenoid complex formation.
33656347	1	48	theme	study	129:133	arg1	modeling					149:156	molecular modeling	139:156	molecular modeling of cyclodextrin (CD)	139:177	The goal of this study was molecular modeling of cyclodextrin (CD) and carotenoid complex formation.
33656347	3	49	theme	complexes	478:486	arg1	formation					465:473	the formation	461:473	the formation of complexes from dispersed CD molecules	461:514	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	50	theme	carotenoid	638:647	arg1	CDs					560:562	five different CDs	545:562	five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD)	545:613	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	50	theme	carotenoid	638:647	arg1	lutein					619:624	lutein	619:624	lutein	619:624	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	3	50	theme	carotenoid	638:647	arg1	molecule					649:656	a model carotenoid molecule	630:656	a model carotenoid molecule	630:656	First, the formation of complexes from dispersed CD molecules was investigated considering five different CDs (αCD, βCD, methyl-βCD, hydroxypropyl-βCD, and γCD) and lutein, as a model carotenoid molecule.
33656347	4	51	theme	steric	781:786	arg1	hindrance					788:796	steric hindrance	781:796	steric hindrance	781:796	The interactions involved and the stability of the different complexes formed were evaluated according to the CD size and steric hindrance.
33656347	7	52	theme	carotenoids	1237:1247	arg1	adsorption					1219:1228	the adsorption	1215:1228	the adsorption of the carotenoids	1215:1247	The findings highlight that all the CD faces, and thus their growth rates, were equally impacted by the adsorption of the carotenoids.
33656347	7	53	theme	growth	1176:1181	arg1	rates					1183:1187	their growth rates	1170:1187	their growth rates	1170:1187	The findings highlight that all the CD faces, and thus their growth rates, were equally impacted by the adsorption of the carotenoids.
33656347	5	54	with	methyl-βCD	918:927	arg1	contents					905:912	three different water contents	883:912	three different water contents	883:912	Second, the formation of complexes between four different crystalline CDs (βCD with three different water contents and methyl-βCD) and three carotenoid molecules (lutein, lycopene, and β-carotene) was studied.
33656347	1	55	theme	molecular	139:147	arg1	goal					116:119	The goal	112:119	The goal of this study	112:133	The goal of this study was molecular modeling of cyclodextrin (CD) and carotenoid complex formation.
33656347	1	55	theme	molecular	139:147	arg1	modeling					149:156	molecular modeling	139:156	molecular modeling of cyclodextrin (CD)	139:177	The goal of this study was molecular modeling of cyclodextrin (CD) and carotenoid complex formation.
33448622	17	0	theme	membrane	1963:1970	arg1	proteins					1972:1979	platelet membrane proteins	1954:1979	platelet membrane proteins	1954:1979	CONCLUSION The polyanionic proteoglycan SRGN influences α-granule packaging, cargo release, and shedding of platelet membrane proteins.
33448622	4	1	theme	sulfated	590:597	arg1	macromolecule					599:611	a major sulfated macromolecule	582:611	a major sulfated macromolecule in megakaryocytes	582:629	RESULTS Metabolic, 35 SO4 labeling identified SRGN as a major sulfated macromolecule in megakaryocytes.
33448622	4	1	theme	sulfated	590:597	arg1	SRGN					574:577	SRGN	574:577	SRGN	574:577	RESULTS Metabolic, 35 SO4 labeling identified SRGN as a major sulfated macromolecule in megakaryocytes.
33448622	6	2	theme	Platelet	808:815	arg1	composition					827:837	Platelet α-granule composition	808:837	Platelet α-granule composition	808:837	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	6	3	theme	pI	888:889	arg1	≥8					891:892	pI ≥8	888:892	pI ≥8	888:892	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	11	4	theme	Ultrastructural	1353:1367	arg1	studies					1369:1375	Ultrastructural studies	1353:1375	Ultrastructural studies	1353:1375	Ultrastructural studies showed distinct morphologies in activated platelets.
33448622	9	5	theme	PF4	1142:1144	arg1	exocytosis					1128:1137	Thrombin-induced exocytosis	1111:1137	Thrombin-induced exocytosis of PF4 from platelets	1111:1159	Thrombin-induced exocytosis of PF4 from platelets was defective; however, release of RANTES/CCL5 was normal and osteopontin secretion was more rapid.
33448622	2	6	theme	platelet	282:289	arg1	packaging					299:307	platelet granule packaging	282:307	platelet granule packaging	282:307	OBJECTIVE To understand how SRGN affects platelet granule packaging, cargo release, and extra-platelet microenvironments.
33448622	6	7	dep	≥8	891:892	arg1	angiogenin					913:922	angiogenin	913:922	angiogenin	913:922	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	6	7	dep	≥8	891:892	arg1	SDF-1					906:910	SDF-1	906:910	SDF-1	906:910	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	6	7	dep	≥8	891:892	arg1	PF4					901:903	PF4	901:903	PF4	901:903	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	6	7	dep	≥8	891:892	arg1	e.g.					895:898	e.g.	895:898	e.g.	895:898	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	13	8	theme	α-Granule	1573:1581	arg1	swelling					1583:1590	α-Granule swelling	1573:1590	α-Granule swelling	1573:1590	α-Granule swelling and decondensation were reduced in SRGN-/- platelets.
33448622	17	9	theme	α-granule	1902:1910	arg1	packaging					1912:1920	α-granule packaging	1902:1920	α-granule packaging	1902:1920	CONCLUSION The polyanionic proteoglycan SRGN influences α-granule packaging, cargo release, and shedding of platelet membrane proteins.
33448622	2	10	theme	cargo	310:314	arg1	release					316:322	cargo release	310:322	cargo release	310:322	OBJECTIVE To understand how SRGN affects platelet granule packaging, cargo release, and extra-platelet microenvironments.
33448622	1	11	theme	hematopoietic	174:186	arg1	cells					188:192	hematopoietic cells	174:192	hematopoietic cells	174:192	BACKGROUND Serglycin (SRGN) is an intragranular, sulfated proteoglycan in hematopoietic cells that affects granule composition and function.
33448622	14	12	theme	SRGN/PF4	1679:1686	arg1	complex					1688:1694	a SRGN/PF4 complex	1677:1694	a SRGN/PF4 complex	1677:1694	Upon stimulation of platelets, a SRGN/PF4 complex was released in a time- and agonist-dependent manner.
33448622	1	13	theme	granule	207:213	arg1	composition					215:225	granule composition	207:225	granule composition	207:225	BACKGROUND Serglycin (SRGN) is an intragranular, sulfated proteoglycan in hematopoietic cells that affects granule composition and function.
33448622	9	14	theme	RANTES/CCL5	1196:1206	arg1	release					1185:1191	release	1185:1191	release of RANTES/CCL5	1185:1206	Thrombin-induced exocytosis of PF4 from platelets was defective; however, release of RANTES/CCL5 was normal and osteopontin secretion was more rapid.
33448622	9	15	from	platelets	1151:1159	arg1	exocytosis					1128:1137	Thrombin-induced exocytosis	1111:1137	Thrombin-induced exocytosis of PF4 from platelets	1111:1159	Thrombin-induced exocytosis of PF4 from platelets was defective; however, release of RANTES/CCL5 was normal and osteopontin secretion was more rapid.
33448622	5	16	theme	Willebrand	702:711	arg1	markers					664:670	α-granule markers	654:670	α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin)	654:741	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	5	16	theme	Willebrand	702:711	arg1	factor					713:718	von Willebrand factor [VWF]	698:724	von Willebrand factor [VWF]	698:724	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	9	17	theme	osteopontin	1223:1233	arg1	secretion					1235:1243	osteopontin secretion	1223:1243	osteopontin secretion	1223:1243	Thrombin-induced exocytosis of PF4 from platelets was defective; however, release of RANTES/CCL5 was normal and osteopontin secretion was more rapid.
33448622	15	18	from	platelets	1780:1788	arg1	Shedding					1750:1757	Shedding	1750:1757	Shedding of GPVI from SRGN-/- platelets	1750:1788	Shedding of GPVI from SRGN-/- platelets was modestly enhanced.
33448622	0	19	theme	luminal	67:73	arg1	serglycin					89:97	serglycin	89:97	serglycin	89:97	Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin.
33448622	0	19	theme	luminal	67:73	arg1	proteoglycan					75:86	the luminal proteoglycan	63:86	the luminal proteoglycan	63:86	Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin.
33448622	16	20	theme	GP1b	1825:1828	arg1	Shedding					1813:1820	Shedding	1813:1820	Shedding of GP1b	1813:1828	Shedding of GP1b was unaffected.
33448622	12	21	theme	grainy	1476:1481	arg1	pattern					1492:1498	a grainy staining pattern	1474:1498	a grainy staining pattern	1474:1498	The α-granule lumen of SRGN-/- platelet had a grainy staining pattern, whereas that of wild-type granules had only fibrous material remaining.
33448622	4	22	from	macromolecule	599:611	arg1	megakaryocytes					616:629	megakaryocytes	616:629	megakaryocytes	616:629	RESULTS Metabolic, 35 SO4 labeling identified SRGN as a major sulfated macromolecule in megakaryocytes.
33448622	6	23	theme	constitutive	929:940	arg1	release					942:948	constitutive release	929:948	constitutive release of PF4 from SRGN-/- megakaryocytes	929:983	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	6	24	from	release	942:948	arg1	proteins					878:885	basic proteins	872:885	basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin)	872:923	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	3	25	theme	cargo	455:459	arg1	levels					461:466	cargo levels	455:466	cargo levels	455:466	METHODS Platelets and megakaryocytes from SRGN-/- mice were assayed for secretion kinetics, cargo levels, granule morphology upon activation, and receptor shedding.
33448622	17	26	theme	proteoglycan	1873:1884	arg1	SRGN					1886:1889	The polyanionic proteoglycan SRGN	1857:1889	The polyanionic proteoglycan SRGN	1857:1889	CONCLUSION The polyanionic proteoglycan SRGN influences α-granule packaging, cargo release, and shedding of platelet membrane proteins.
33448622	3	27	theme	SRGN-/-	405:411	arg1	mice					413:416	SRGN-/- mice	405:416	SRGN-/- mice	405:416	METHODS Platelets and megakaryocytes from SRGN-/- mice were assayed for secretion kinetics, cargo levels, granule morphology upon activation, and receptor shedding.
33448622	1	28	dep	intragranular	134:146	arg1	sulfated					149:156	sulfated	149:156	sulfated	149:156	BACKGROUND Serglycin (SRGN) is an intragranular, sulfated proteoglycan in hematopoietic cells that affects granule composition and function.
33448622	0	29	theme	Platelet	0:7	arg1	packaging					25:33	Platelet α-granule cargo packaging	0:33	Platelet α-granule cargo packaging	0:33	Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin.
33448622	0	30	theme	cargo	19:23	arg1	packaging					25:33	Platelet α-granule cargo packaging	0:33	Platelet α-granule cargo packaging	0:33	Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin.
33448622	12	31	theme	platelet	1461:1468	arg1	lumen					1444:1448	The α-granule lumen	1430:1448	The α-granule lumen of SRGN-/- platelet	1430:1468	The α-granule lumen of SRGN-/- platelet had a grainy staining pattern, whereas that of wild-type granules had only fibrous material remaining.
33448622	1	32	theme	BACKGROUND	100:109	arg1	SRGN					122:125	SRGN	122:125	SRGN	122:125	BACKGROUND Serglycin (SRGN) is an intragranular, sulfated proteoglycan in hematopoietic cells that affects granule composition and function.
33448622	1	32	theme	BACKGROUND	100:109	arg1	Serglycin					111:119	BACKGROUND Serglycin	100:119	BACKGROUND Serglycin (SRGN)	100:126	BACKGROUND Serglycin (SRGN) is an intragranular, sulfated proteoglycan in hematopoietic cells that affects granule composition and function.
33448622	1	32	theme	BACKGROUND	100:109	arg1	proteoglycan					158:169	an intragranular, sulfated proteoglycan	131:169	an intragranular, sulfated proteoglycan in hematopoietic cells that affects granule composition and function	131:238	BACKGROUND Serglycin (SRGN) is an intragranular, sulfated proteoglycan in hematopoietic cells that affects granule composition and function.
33448622	5	33	dep	markers	664:670	arg1	markers					664:670	α-granule markers	654:670	α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin)	654:741	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	5	33	dep	markers	664:670	arg1	factor					682:687	platelet factor 4	673:689	platelet factor 4 [PF4]	673:695	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	5	33	dep	markers	664:670	arg1	P-selectin					731:740	P-selectin	731:740	P-selectin	731:740	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	5	33	dep	markers	664:670	arg1	factor					713:718	von Willebrand factor [VWF]	698:724	von Willebrand factor [VWF]	698:724	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	13	34	theme	SRGN-/-	1627:1633	arg1	platelets					1635:1643	SRGN-/- platelets	1627:1643	SRGN-/- platelets	1627:1643	α-Granule swelling and decondensation were reduced in SRGN-/- platelets.
33448622	11	35	theme	activated	1409:1417	arg1	platelets					1419:1427	activated platelets	1409:1427	activated platelets	1409:1427	Ultrastructural studies showed distinct morphologies in activated platelets.
33448622	4	36	dep	Metabolic	536:544	arg1	labeling					554:561	labeling	554:561	labeling	554:561	RESULTS Metabolic, 35 SO4 labeling identified SRGN as a major sulfated macromolecule in megakaryocytes.
33448622	6	37	theme	SRGN-/-	962:968	arg1	megakaryocytes					970:983	SRGN-/- megakaryocytes	962:983	SRGN-/- megakaryocytes	962:983	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	10	38	theme	HEXB	1281:1284	arg1	Release					1261:1267	Release	1261:1267	Release of 5-HT and HEXB (from dense granules and lysosomes, respectively)	1261:1334	Release of 5-HT and HEXB (from dense granules and lysosomes, respectively) were unaffected.
33448622	12	39	theme	α-granule	1434:1442	arg1	lumen					1444:1448	The α-granule lumen	1430:1448	The α-granule lumen of SRGN-/- platelet	1430:1468	The α-granule lumen of SRGN-/- platelet had a grainy staining pattern, whereas that of wild-type granules had only fibrous material remaining.
33448622	5	40	theme	α-granule	654:662	arg1	markers					664:670	α-granule markers	654:670	α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin)	654:741	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	5	40	theme	α-granule	654:662	arg1	factor					682:687	platelet factor 4	673:689	platelet factor 4 [PF4]	673:695	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	5	40	theme	α-granule	654:662	arg1	P-selectin					731:740	P-selectin	731:740	P-selectin	731:740	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	5	40	theme	α-granule	654:662	arg1	factor					713:718	von Willebrand factor [VWF]	698:724	von Willebrand factor [VWF]	698:724	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	4	41	theme	SO4	550:552	arg1	labeling					554:561	labeling	554:561	labeling	554:561	RESULTS Metabolic, 35 SO4 labeling identified SRGN as a major sulfated macromolecule in megakaryocytes.
33448622	12	42	contain	had	1536:1538	arg1	that					1509:1512	that	1509:1512	that	1509:1512	The α-granule lumen of SRGN-/- platelet had a grainy staining pattern, whereas that of wild-type granules had only fibrous material remaining.
33448622	12	42	contain	had	1536:1538	arg2	material					1553:1560	only fibrous material remaining	1540:1570	only fibrous material remaining	1540:1570	The α-granule lumen of SRGN-/- platelet had a grainy staining pattern, whereas that of wild-type granules had only fibrous material remaining.
33448622	14	43	theme	agonist-dependent	1724:1740	arg1	manner					1742:1747	agonist-dependent manner	1724:1747	agonist-dependent manner	1724:1747	Upon stimulation of platelets, a SRGN/PF4 complex was released in a time- and agonist-dependent manner.
33448622	17	44	theme	platelet	1954:1961	arg1	proteins					1972:1979	platelet membrane proteins	1954:1979	platelet membrane proteins	1954:1979	CONCLUSION The polyanionic proteoglycan SRGN influences α-granule packaging, cargo release, and shedding of platelet membrane proteins.
33448622	11	45	from	morphologies	1393:1404	arg1	platelets					1419:1427	activated platelets	1409:1427	activated platelets	1409:1427	Ultrastructural studies showed distinct morphologies in activated platelets.
33448622	6	46	dep	proteins	878:885	arg1	≥8					891:892	pI ≥8	888:892	pI ≥8	888:892	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	5	47	theme	platelet	673:680	arg1	markers					664:670	α-granule markers	654:670	α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin)	654:741	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	5	47	theme	platelet	673:680	arg1	factor					682:687	platelet factor 4	673:689	platelet factor 4 [PF4]	673:695	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	9	48	theme	Thrombin-induced	1111:1126	arg1	exocytosis					1128:1137	Thrombin-induced exocytosis	1111:1137	Thrombin-induced exocytosis of PF4 from platelets	1111:1159	Thrombin-induced exocytosis of PF4 from platelets was defective; however, release of RANTES/CCL5 was normal and osteopontin secretion was more rapid.
33448622	17	49	theme	proteins	1972:1979	arg1	packaging					1912:1920	α-granule packaging	1902:1920	α-granule packaging	1902:1920	CONCLUSION The polyanionic proteoglycan SRGN influences α-granule packaging, cargo release, and shedding of platelet membrane proteins.
33448622	17	49	theme	proteins	1972:1979	arg1	release					1929:1935	cargo release	1923:1935	cargo release	1923:1935	CONCLUSION The polyanionic proteoglycan SRGN influences α-granule packaging, cargo release, and shedding of platelet membrane proteins.
33448622	17	49	theme	proteins	1972:1979	arg1	shedding					1942:1949	shedding	1942:1949	shedding of platelet membrane proteins	1942:1979	CONCLUSION The polyanionic proteoglycan SRGN influences α-granule packaging, cargo release, and shedding of platelet membrane proteins.
33448622	4	50	theme	major	584:588	arg1	macromolecule					599:611	a major sulfated macromolecule	582:611	a major sulfated macromolecule in megakaryocytes	582:629	RESULTS Metabolic, 35 SO4 labeling identified SRGN as a major sulfated macromolecule in megakaryocytes.
33448622	4	50	theme	major	584:588	arg1	SRGN					574:577	SRGN	574:577	SRGN	574:577	RESULTS Metabolic, 35 SO4 labeling identified SRGN as a major sulfated macromolecule in megakaryocytes.
33448622	2	51	theme	granule	291:297	arg1	packaging					299:307	platelet granule packaging	282:307	platelet granule packaging	282:307	OBJECTIVE To understand how SRGN affects platelet granule packaging, cargo release, and extra-platelet microenvironments.
33448622	6	52	theme	basic	872:876	arg1	proteins					878:885	basic proteins	872:885	basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin)	872:923	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	6	53	theme	PF4	953:955	arg1	release					942:948	constitutive release	929:948	constitutive release of PF4 from SRGN-/- megakaryocytes	929:983	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	6	53	theme	PF4	953:955	arg1	reduction					859:867	a reduction	857:867	a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin)	857:923	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	12	54	theme	remaining	1562:1570	arg1	material					1553:1560	only fibrous material remaining	1540:1570	only fibrous material remaining	1540:1570	The α-granule lumen of SRGN-/- platelet had a grainy staining pattern, whereas that of wild-type granules had only fibrous material remaining.
33448622	6	55	from	reduction	859:867	arg1	proteins					878:885	basic proteins	872:885	basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin)	872:923	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	17	56	theme	cargo	1923:1927	arg1	release					1929:1935	cargo release	1923:1935	cargo release	1923:1935	CONCLUSION The polyanionic proteoglycan SRGN influences α-granule packaging, cargo release, and shedding of platelet membrane proteins.
33448622	2	57	theme	extra-platelet	329:342	arg1	microenvironments					344:360	extra-platelet microenvironments	329:360	extra-platelet microenvironments	329:360	OBJECTIVE To understand how SRGN affects platelet granule packaging, cargo release, and extra-platelet microenvironments.
33448622	14	58	theme	platelets	1666:1674	arg1	stimulation					1651:1661	stimulation	1651:1661	stimulation of platelets	1651:1674	Upon stimulation of platelets, a SRGN/PF4 complex was released in a time- and agonist-dependent manner.
33448622	12	59	theme	fibrous	1545:1551	arg1	material					1553:1560	only fibrous material remaining	1540:1570	only fibrous material remaining	1540:1570	The α-granule lumen of SRGN-/- platelet had a grainy staining pattern, whereas that of wild-type granules had only fibrous material remaining.
33448622	5	60	theme	von	698:700	arg1	markers					664:670	α-granule markers	654:670	α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin)	654:741	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	5	60	theme	von	698:700	arg1	factor					713:718	von Willebrand factor [VWF]	698:724	von Willebrand factor [VWF]	698:724	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	10	61	theme	5-HT	1272:1275	arg1	Release					1261:1267	Release	1261:1267	Release of 5-HT and HEXB (from dense granules and lysosomes, respectively)	1261:1334	Release of 5-HT and HEXB (from dense granules and lysosomes, respectively) were unaffected.
33448622	12	62	theme	wild-type	1517:1525	arg1	granules					1527:1534	wild-type granules	1517:1534	wild-type granules	1517:1534	The α-granule lumen of SRGN-/- platelet had a grainy staining pattern, whereas that of wild-type granules had only fibrous material remaining.
33448622	12	63	contain	had	1470:1472	arg1	lumen					1444:1448	The α-granule lumen	1430:1448	The α-granule lumen of SRGN-/- platelet	1430:1468	The α-granule lumen of SRGN-/- platelet had a grainy staining pattern, whereas that of wild-type granules had only fibrous material remaining.
33448622	12	63	contain	had	1470:1472	arg2	pattern					1492:1498	a grainy staining pattern	1474:1498	a grainy staining pattern	1474:1498	The α-granule lumen of SRGN-/- platelet had a grainy staining pattern, whereas that of wild-type granules had only fibrous material remaining.
33448622	1	64	from	proteoglycan	158:169	arg1	cells					188:192	hematopoietic cells	174:192	hematopoietic cells	174:192	BACKGROUND Serglycin (SRGN) is an intragranular, sulfated proteoglycan in hematopoietic cells that affects granule composition and function.
33448622	1	65	theme	intragranular	134:146	arg1	Serglycin					111:119	BACKGROUND Serglycin	100:119	BACKGROUND Serglycin (SRGN)	100:126	BACKGROUND Serglycin (SRGN) is an intragranular, sulfated proteoglycan in hematopoietic cells that affects granule composition and function.
33448622	1	65	theme	intragranular	134:146	arg1	proteoglycan					158:169	an intragranular, sulfated proteoglycan	131:169	an intragranular, sulfated proteoglycan in hematopoietic cells that affects granule composition and function	131:238	BACKGROUND Serglycin (SRGN) is an intragranular, sulfated proteoglycan in hematopoietic cells that affects granule composition and function.
33448622	12	66	theme	staining	1483:1490	arg1	pattern					1492:1498	a grainy staining pattern	1474:1498	a grainy staining pattern	1474:1498	The α-granule lumen of SRGN-/- platelet had a grainy staining pattern, whereas that of wild-type granules had only fibrous material remaining.
33448622	4	67	theme	Metabolic	536:544	arg1	RESULTS					528:534	RESULTS	528:534	RESULTS Metabolic, 35 SO4 labeling	528:561	RESULTS Metabolic, 35 SO4 labeling identified SRGN as a major sulfated macromolecule in megakaryocytes.
33448622	6	68	from	megakaryocytes	970:983	arg1	release					942:948	constitutive release	929:948	constitutive release of PF4 from SRGN-/- megakaryocytes	929:983	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	6	68	from	megakaryocytes	970:983	arg1	reduction					859:867	a reduction	857:867	a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin)	857:923	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	11	69	theme	distinct	1384:1391	arg1	morphologies					1393:1404	distinct morphologies	1384:1404	distinct morphologies in activated platelets	1384:1427	Ultrastructural studies showed distinct morphologies in activated platelets.
33448622	15	70	theme	SRGN-/-	1772:1778	arg1	platelets					1780:1788	SRGN-/- platelets	1772:1788	SRGN-/- platelets	1772:1788	Shedding of GPVI from SRGN-/- platelets was modestly enhanced.
33448622	17	71	theme	polyanionic	1861:1871	arg1	SRGN					1886:1889	The polyanionic proteoglycan SRGN	1857:1889	The polyanionic proteoglycan SRGN	1857:1889	CONCLUSION The polyanionic proteoglycan SRGN influences α-granule packaging, cargo release, and shedding of platelet membrane proteins.
33448622	15	72	theme	GPVI	1762:1765	arg1	Shedding					1750:1757	Shedding	1750:1757	Shedding of GPVI from SRGN-/- platelets	1750:1788	Shedding of GPVI from SRGN-/- platelets was modestly enhanced.
33448622	0	73	theme	α-granule	9:17	arg1	packaging					25:33	Platelet α-granule cargo packaging	0:33	Platelet α-granule cargo packaging	0:33	Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin.
33448622	3	74	from	mice	413:416	arg1	megakaryocytes					385:398	megakaryocytes	385:398	megakaryocytes	385:398	METHODS Platelets and megakaryocytes from SRGN-/- mice were assayed for secretion kinetics, cargo levels, granule morphology upon activation, and receptor shedding.
33448622	3	74	from	mice	413:416	arg1	Platelets					371:379	Platelets	371:379	Platelets	371:379	METHODS Platelets and megakaryocytes from SRGN-/- mice were assayed for secretion kinetics, cargo levels, granule morphology upon activation, and receptor shedding.
33448622	8	75	theme	Serotonin	1035:1043	arg1	uptake					1052:1057	Serotonin (5-HT) uptake	1035:1057	Serotonin (5-HT) uptake	1035:1057	Serotonin (5-HT) uptake and β-hexosaminidase (HEXB) were slightly elevated.
33448622	5	76	dep	factor	682:687	arg1	[PF4					691:694	[PF4	691:694	[PF4	691:694	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	12	77	theme	SRGN-/-	1453:1459	arg1	platelet					1461:1468	SRGN-/- platelet	1453:1468	SRGN-/- platelet	1453:1468	The α-granule lumen of SRGN-/- platelet had a grainy staining pattern, whereas that of wild-type granules had only fibrous material remaining.
33448622	3	78	theme	secretion	435:443	arg1	kinetics					445:452	secretion kinetics	435:452	secretion kinetics	435:452	METHODS Platelets and megakaryocytes from SRGN-/- mice were assayed for secretion kinetics, cargo levels, granule morphology upon activation, and receptor shedding.
33448622	4	79	theme	35	547:548	arg1	labeling					554:561	labeling	554:561	labeling	554:561	RESULTS Metabolic, 35 SO4 labeling identified SRGN as a major sulfated macromolecule in megakaryocytes.
33448622	3	80	theme	granule	469:475	arg1	morphology					477:486	granule morphology	469:486	granule morphology upon activation	469:502	METHODS Platelets and megakaryocytes from SRGN-/- mice were assayed for secretion kinetics, cargo levels, granule morphology upon activation, and receptor shedding.
33448622	5	81	theme	α-granule	776:784	arg1	morphology					786:795	α-granule morphology	776:795	α-granule morphology	776:795	SRGN colocalized with α-granule markers (platelet factor 4 [PF4], von Willebrand factor [VWF], and P-selectin), but its deletion did not affect α-granule morphology or number.
33448622	3	82	dep	METHODS	363:369	arg1	megakaryocytes					385:398	megakaryocytes	385:398	megakaryocytes	385:398	METHODS Platelets and megakaryocytes from SRGN-/- mice were assayed for secretion kinetics, cargo levels, granule morphology upon activation, and receptor shedding.
33448622	3	82	dep	METHODS	363:369	arg1	Platelets					371:379	Platelets	371:379	Platelets	371:379	METHODS Platelets and megakaryocytes from SRGN-/- mice were assayed for secretion kinetics, cargo levels, granule morphology upon activation, and receptor shedding.
33448622	3	83	theme	receptor	509:516	arg1	shedding					518:525	receptor shedding	509:525	receptor shedding	509:525	METHODS Platelets and megakaryocytes from SRGN-/- mice were assayed for secretion kinetics, cargo levels, granule morphology upon activation, and receptor shedding.
33448622	6	84	theme	α-granule	817:825	arg1	composition					827:837	Platelet α-granule composition	808:837	Platelet α-granule composition	808:837	Platelet α-granule composition was altered, with a reduction in basic proteins (pI ≥8; e.g., PF4, SDF-1, angiogenin) and constitutive release of PF4 from SRGN-/- megakaryocytes.
33448622	10	85	theme	dense	1292:1296	arg1	granules					1298:1305	dense granules	1292:1305	dense granules	1292:1305	Release of 5-HT and HEXB (from dense granules and lysosomes, respectively) were unaffected.
33448622	17	86	dep	CONCLUSION	1846:1855	arg1	influences					1891:1900	influences	1891:1900	influences α-granule packaging, cargo release, and shedding of platelet membrane proteins	1891:1979	CONCLUSION The polyanionic proteoglycan SRGN influences α-granule packaging, cargo release, and shedding of platelet membrane proteins.
33453250	6	0	dep	ions	1065:1068	arg1	NO3-					1076:1079	NO3-	1076:1079	NO3-	1076:1079	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	6	0	dep	ions	1065:1068	arg1	SO42-					1082:1086	SO42-	1082:1086	SO42-	1082:1086	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	6	0	dep	ions	1065:1068	arg1	Fe					1100:1101	Fe	1100:1101	Fe	1100:1101	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	6	0	dep	ions	1065:1068	arg1	ions					1065:1068	The coexisting ions	1050:1068	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb)	1050:1110	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	6	0	dep	ions	1065:1068	arg1	Cl-					1071:1073	Cl-	1071:1073	Cl-	1071:1073	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	6	0	dep	ions	1065:1068	arg1	PO43-					1089:1093	PO43-	1089:1093	PO43-	1089:1093	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	6	0	dep	ions	1065:1068	arg1	Pb					1108:1109	Pb	1108:1109	Pb	1108:1109	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	6	0	dep	ions	1065:1068	arg1	As					1096:1097	As	1096:1097	As	1096:1097	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	3	1	theme	adsorption	613:622	arg1	experiments					624:634	batch adsorption experiments	607:634	batch adsorption experiments	607:634	Fe2O3-GO/CS as the only eco-friendly composite for enhanced Cr(VI) removal is further used for batch adsorption experiments, characterization, kinetics, isotherms, and thermodynamic studies.
33453250	5	2	theme	initial	917:923	arg1	concentration					932:944	the increasing initial Cr(VI) concentration	902:944	the increasing initial Cr(VI) concentration	902:944	Qe increases with the increasing initial Cr(VI) concentration, contact time, and temperature, while decreases with the increasing pH and mass and volume ratio (m/v).
33453250	5	3	theme	volume	1030:1035	arg1	ratio					1037:1041	volume ratio	1030:1041	volume ratio (m/v)	1030:1047	Qe increases with the increasing initial Cr(VI) concentration, contact time, and temperature, while decreases with the increasing pH and mass and volume ratio (m/v).
33453250	5	3	theme	volume	1030:1035	arg1	m/v					1044:1046	m/v	1044:1046	m/v	1044:1046	Qe increases with the increasing initial Cr(VI) concentration, contact time, and temperature, while decreases with the increasing pH and mass and volume ratio (m/v).
33453250	1	4	theme	decoration	201:210	arg1	effects					153:159	the effects	149:159	the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution	149:321	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	4	5	dep	includes	742:749	arg1	VI					723:724	VI	723:724	VI	723:724	It is found that Cr(VI) removal mainly includes electrostatic attraction between Cr(VI) oxyanions and surface -NH3+ and -OH2+, and the adsorbed Cr(VI) partially reduces to Cr(III).
33453250	4	6	dep	Cr	847:848	arg1	VI					850:851	VI	850:851	VI	850:851	It is found that Cr(VI) removal mainly includes electrostatic attraction between Cr(VI) oxyanions and surface -NH3+ and -OH2+, and the adsorbed Cr(VI) partially reduces to Cr(III).
33453250	7	7	theme	optimal	1232:1238	arg1	conditions					1240:1249	the optimal conditions	1228:1249	the optimal conditions	1228:1249	The removal efficiency (Re) and Qe are 94.3% and 83.8 mg/g, respectively under the optimal conditions.
33453250	6	8	theme	Qe	1145:1146	arg1	decrease					1133:1140	an obvious decrease	1122:1140	an obvious decrease of Qe	1122:1146	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	1	9	theme	graphene	215:222	arg1	composites					247:256	graphene oxide/chitosan (GO/CS) composites	215:256	graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution	215:321	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	9	10	dep	adsorption	1345:1354	arg1	VI					1341:1342	VI	1341:1342	VI	1341:1342	Cr(VI) adsorption is spontaneous and endothermic, which is best fitted with the Sips model, and the fitted maximum Qe is 131.33 mg/g.
33453250	1	11	theme	oxide/chitosan	224:237	arg1	composites					247:256	graphene oxide/chitosan (GO/CS) composites	215:256	graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution	215:321	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	0	12	theme	aqueous	95:101	arg1	solution					103:110	aqueous solution	95:110	aqueous solution	95:110	Iron oxides decorated graphene oxide/chitosan composite beads for enhanced Cr(VI) removal from aqueous solution.
33453250	7	13	theme	removal	1153:1159	arg1	Re					1173:1174	Re	1173:1174	Re	1173:1174	The removal efficiency (Re) and Qe are 94.3% and 83.8 mg/g, respectively under the optimal conditions.
33453250	7	13	theme	removal	1153:1159	arg1	%					1192:1192	94.3%	1188:1192	94.3%	1188:1192	The removal efficiency (Re) and Qe are 94.3% and 83.8 mg/g, respectively under the optimal conditions.
33453250	7	13	theme	removal	1153:1159	arg1	efficiency					1161:1170	The removal efficiency	1149:1170	The removal efficiency (Re)	1149:1175	The removal efficiency (Re) and Qe are 94.3% and 83.8 mg/g, respectively under the optimal conditions.
33453250	7	13	theme	removal	1153:1159	arg1	Qe					1181:1182	Qe	1181:1182	Qe	1181:1182	The removal efficiency (Re) and Qe are 94.3% and 83.8 mg/g, respectively under the optimal conditions.
33453250	4	14	dep	reduces	864:870	arg1	to					872:873	to	872:873	to	872:873	It is found that Cr(VI) removal mainly includes electrostatic attraction between Cr(VI) oxyanions and surface -NH3+ and -OH2+, and the adsorbed Cr(VI) partially reduces to Cr(III).
33453250	0	15	dep	removal	82:88	arg1	VI					78:79	VI	78:79	VI	78:79	Iron oxides decorated graphene oxide/chitosan composite beads for enhanced Cr(VI) removal from aqueous solution.
33453250	3	16	used	used	598:601	arg2	Fe2O3-GO/CS					512:522	Fe2O3-GO/CS	512:522	Fe2O3-GO/CS as the only eco-friendly composite for enhanced Cr(VI) removal	512:585	Fe2O3-GO/CS as the only eco-friendly composite for enhanced Cr(VI) removal is further used for batch adsorption experiments, characterization, kinetics, isotherms, and thermodynamic studies.
33453250	1	17	theme	Fe	300:301	arg1	pollution					313:321	Fe secondary pollution	300:321	Fe secondary pollution	300:321	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	4	18	theme	adsorbed	838:845	arg1	Cr					847:848	the adsorbed Cr	834:848	the adsorbed Cr(VI)	834:852	It is found that Cr(VI) removal mainly includes electrostatic attraction between Cr(VI) oxyanions and surface -NH3+ and -OH2+, and the adsorbed Cr(VI) partially reduces to Cr(III).
33453250	3	19	theme	thermodynamic	680:692	arg1	studies					694:700	thermodynamic studies	680:700	thermodynamic studies	680:700	Fe2O3-GO/CS as the only eco-friendly composite for enhanced Cr(VI) removal is further used for batch adsorption experiments, characterization, kinetics, isotherms, and thermodynamic studies.
33453250	2	20	theme	better	355:360	arg1	Fe					342:343	Fe(III)	342:348	Fe(III)	342:348	Results show that Fe(III) is a better decoration material than Fe(II) and decoration through immersion-evaporation shows a higher adsorption capacity of Cr(VI) (Qe) than co-precipitation.
33453250	2	20	theme	better	355:360	arg1	decoration					362:371	a better decoration	353:371	a better decoration material than Fe(II)	353:392	Results show that Fe(III) is a better decoration material than Fe(II) and decoration through immersion-evaporation shows a higher adsorption capacity of Cr(VI) (Qe) than co-precipitation.
33453250	1	21	theme	secondary	303:311	arg1	pollution					313:321	Fe secondary pollution	300:321	Fe secondary pollution	300:321	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	2	22	dep	Cr	477:478	arg1	VI					480:481	VI	480:481	VI	480:481	Results show that Fe(III) is a better decoration material than Fe(II) and decoration through immersion-evaporation shows a higher adsorption capacity of Cr(VI) (Qe) than co-precipitation.
33453250	0	23	theme	Iron	0:3	arg1	oxides					5:10	Iron oxides	0:10	Iron oxides	0:10	Iron oxides decorated graphene oxide/chitosan composite beads for enhanced Cr(VI) removal from aqueous solution.
33453250	0	24	theme	graphene	22:29	arg1	beads					56:60	graphene oxide/chitosan composite beads	22:60	graphene oxide/chitosan composite beads	22:60	Iron oxides decorated graphene oxide/chitosan composite beads for enhanced Cr(VI) removal from aqueous solution.
33453250	1	25	theme	GO/CS	240:244	arg1	composites					247:256	graphene oxide/chitosan (GO/CS) composites	215:256	graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution	215:321	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	1	26	theme	Iron	164:167	arg1	species					183:189	Iron oxides (FeOx) species	164:189	Iron oxides (FeOx) species	164:189	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	9	27	theme	Sips	1418:1421	arg1	model					1423:1427	the Sips model	1414:1427	the Sips model	1414:1427	Cr(VI) adsorption is spontaneous and endothermic, which is best fitted with the Sips model, and the fitted maximum Qe is 131.33 mg/g.
33453250	3	28	theme	batch	607:611	arg1	experiments					624:634	batch adsorption experiments	607:634	batch adsorption experiments	607:634	Fe2O3-GO/CS as the only eco-friendly composite for enhanced Cr(VI) removal is further used for batch adsorption experiments, characterization, kinetics, isotherms, and thermodynamic studies.
33453250	2	29	theme	adsorption	454:463	arg1	capacity					465:472	a higher adsorption capacity	445:472	a higher adsorption capacity of Cr(VI) (Qe) than co-precipitation	445:509	Results show that Fe(III) is a better decoration material than Fe(II) and decoration through immersion-evaporation shows a higher adsorption capacity of Cr(VI) (Qe) than co-precipitation.
33453250	1	30	theme	pollution	313:321	arg1	removal					269:275	Cr(VI) removal	262:275	Cr(VI) removal	262:275	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	1	30	theme	pollution	313:321	arg1	possibility					285:295	the possibility	281:295	the possibility of Fe secondary pollution	281:321	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	1	31	theme	oxides	169:174	arg1	species					183:189	Iron oxides (FeOx) species	164:189	Iron oxides (FeOx) species	164:189	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	0	32	theme	composite	46:54	arg1	beads					56:60	graphene oxide/chitosan composite beads	22:60	graphene oxide/chitosan composite beads	22:60	Iron oxides decorated graphene oxide/chitosan composite beads for enhanced Cr(VI) removal from aqueous solution.
33453250	1	33	dep	removal	269:275	arg1	VI					265:266	VI	265:266	VI	265:266	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	2	34	theme	higher	447:452	arg1	capacity					465:472	a higher adsorption capacity	445:472	a higher adsorption capacity of Cr(VI) (Qe) than co-precipitation	445:509	Results show that Fe(III) is a better decoration material than Fe(II) and decoration through immersion-evaporation shows a higher adsorption capacity of Cr(VI) (Qe) than co-precipitation.
33453250	3	35	theme	eco-friendly	536:547	arg1	composite					549:557	the only eco-friendly composite	527:557	the only eco-friendly composite for enhanced Cr(VI) removal	527:585	Fe2O3-GO/CS as the only eco-friendly composite for enhanced Cr(VI) removal is further used for batch adsorption experiments, characterization, kinetics, isotherms, and thermodynamic studies.
33453250	0	36	theme	oxide/chitosan	31:44	arg1	beads					56:60	graphene oxide/chitosan composite beads	22:60	graphene oxide/chitosan composite beads	22:60	Iron oxides decorated graphene oxide/chitosan composite beads for enhanced Cr(VI) removal from aqueous solution.
33453250	9	37	theme	Cr	1338:1339	arg1	adsorption					1345:1354	Cr(VI) adsorption	1338:1354	Cr(VI) adsorption	1338:1354	Cr(VI) adsorption is spontaneous and endothermic, which is best fitted with the Sips model, and the fitted maximum Qe is 131.33 mg/g.
33453250	6	38	theme	obvious	1125:1131	arg1	decrease					1133:1140	an obvious decrease	1122:1140	an obvious decrease of Qe	1122:1146	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	1	39	theme	FeOx	177:180	arg1	species					183:189	Iron oxides (FeOx) species	164:189	Iron oxides (FeOx) species	164:189	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	2	40	theme	material	373:380	arg1	Fe					342:343	Fe(III)	342:348	Fe(III)	342:348	Results show that Fe(III) is a better decoration material than Fe(II) and decoration through immersion-evaporation shows a higher adsorption capacity of Cr(VI) (Qe) than co-precipitation.
33453250	2	40	theme	material	373:380	arg1	decoration					362:371	a better decoration	353:371	a better decoration material than Fe(II)	353:392	Results show that Fe(III) is a better decoration material than Fe(II) and decoration through immersion-evaporation shows a higher adsorption capacity of Cr(VI) (Qe) than co-precipitation.
33453250	1	41	theme	Cr	262:263	arg1	removal					269:275	Cr(VI) removal	262:275	Cr(VI) removal	262:275	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	4	42	theme	electrostatic	751:763	arg1	attraction					765:774	electrostatic attraction	751:774	electrostatic attraction between Cr(VI) oxyanions and surface -NH3+ and -OH2+	751:827	It is found that Cr(VI) removal mainly includes electrostatic attraction between Cr(VI) oxyanions and surface -NH3+ and -OH2+, and the adsorbed Cr(VI) partially reduces to Cr(III).
33453250	5	43	theme	increasing	906:915	arg1	concentration					932:944	the increasing initial Cr(VI) concentration	902:944	the increasing initial Cr(VI) concentration	902:944	Qe increases with the increasing initial Cr(VI) concentration, contact time, and temperature, while decreases with the increasing pH and mass and volume ratio (m/v).
33453250	5	44	dep	concentration	932:944	arg1	VI					928:929	VI	928:929	VI	928:929	Qe increases with the increasing initial Cr(VI) concentration, contact time, and temperature, while decreases with the increasing pH and mass and volume ratio (m/v).
33453250	5	45	theme	contact	947:953	arg1	time					955:958	contact time	947:958	contact time	947:958	Qe increases with the increasing initial Cr(VI) concentration, contact time, and temperature, while decreases with the increasing pH and mass and volume ratio (m/v).
33453250	3	46	theme	enhanced	563:570	arg1	removal					579:585	enhanced Cr(VI) removal	563:585	enhanced Cr(VI) removal	563:585	Fe2O3-GO/CS as the only eco-friendly composite for enhanced Cr(VI) removal is further used for batch adsorption experiments, characterization, kinetics, isotherms, and thermodynamic studies.
33453250	9	47	theme	fitted	1438:1443	arg1	Qe					1453:1454	the fitted maximum Qe	1434:1454	the fitted maximum Qe	1434:1454	Cr(VI) adsorption is spontaneous and endothermic, which is best fitted with the Sips model, and the fitted maximum Qe is 131.33 mg/g.
33453250	9	47	theme	fitted	1438:1443	arg1	131.33 mg/g					1459:1469	131.33 mg/g	1459:1469	131.33 mg/g	1459:1469	Cr(VI) adsorption is spontaneous and endothermic, which is best fitted with the Sips model, and the fitted maximum Qe is 131.33 mg/g.
33453250	2	48	theme	Cr	477:478	arg1	capacity					465:472	a higher adsorption capacity	445:472	a higher adsorption capacity of Cr(VI) (Qe) than co-precipitation	445:509	Results show that Fe(III) is a better decoration material than Fe(II) and decoration through immersion-evaporation shows a higher adsorption capacity of Cr(VI) (Qe) than co-precipitation.
33453250	3	49	theme	Cr	572:573	arg1	removal					579:585	enhanced Cr(VI) removal	563:585	enhanced Cr(VI) removal	563:585	Fe2O3-GO/CS as the only eco-friendly composite for enhanced Cr(VI) removal is further used for batch adsorption experiments, characterization, kinetics, isotherms, and thermodynamic studies.
33453250	3	50	dep	removal	579:585	arg1	VI					575:576	VI	575:576	VI	575:576	Fe2O3-GO/CS as the only eco-friendly composite for enhanced Cr(VI) removal is further used for batch adsorption experiments, characterization, kinetics, isotherms, and thermodynamic studies.
33453250	4	51	dep	Cr	784:785	arg1	oxyanions					791:799	oxyanions	791:799	oxyanions	791:799	It is found that Cr(VI) removal mainly includes electrostatic attraction between Cr(VI) oxyanions and surface -NH3+ and -OH2+, and the adsorbed Cr(VI) partially reduces to Cr(III).
33453250	4	51	dep	Cr	784:785	arg1	VI					787:788	VI	787:788	VI	787:788	It is found that Cr(VI) removal mainly includes electrostatic attraction between Cr(VI) oxyanions and surface -NH3+ and -OH2+, and the adsorbed Cr(VI) partially reduces to Cr(III).
33453250	9	52	theme	maximum	1445:1451	arg1	Qe					1453:1454	the fitted maximum Qe	1434:1454	the fitted maximum Qe	1434:1454	Cr(VI) adsorption is spontaneous and endothermic, which is best fitted with the Sips model, and the fitted maximum Qe is 131.33 mg/g.
33453250	9	52	theme	maximum	1445:1451	arg1	131.33 mg/g					1459:1469	131.33 mg/g	1459:1469	131.33 mg/g	1459:1469	Cr(VI) adsorption is spontaneous and endothermic, which is best fitted with the Sips model, and the fitted maximum Qe is 131.33 mg/g.
33453250	5	53	theme	increasing	1003:1012	arg1	pH					1014:1015	pH	1014:1015	pH	1014:1015	Qe increases with the increasing initial Cr(VI) concentration, contact time, and temperature, while decreases with the increasing pH and mass and volume ratio (m/v).
33453250	6	54	theme	coexisting	1054:1063	arg1	NO3-					1076:1079	NO3-	1076:1079	NO3-	1076:1079	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	6	54	theme	coexisting	1054:1063	arg1	SO42-					1082:1086	SO42-	1082:1086	SO42-	1082:1086	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	6	54	theme	coexisting	1054:1063	arg1	Fe					1100:1101	Fe	1100:1101	Fe	1100:1101	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	6	54	theme	coexisting	1054:1063	arg1	ions					1065:1068	The coexisting ions	1050:1068	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb)	1050:1110	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	6	54	theme	coexisting	1054:1063	arg1	Cl-					1071:1073	Cl-	1071:1073	Cl-	1071:1073	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	6	54	theme	coexisting	1054:1063	arg1	PO43-					1089:1093	PO43-	1089:1093	PO43-	1089:1093	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	6	54	theme	coexisting	1054:1063	arg1	Pb					1108:1109	Pb	1108:1109	Pb	1108:1109	The coexisting ions (Cl-, NO3-, SO42-, PO43-, As, Fe, and Pb) can cause an obvious decrease of Qe.
33453250	1	55	from	effects	153:159	arg1	composites					247:256	graphene oxide/chitosan (GO/CS) composites	215:256	graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution	215:321	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	1	56	theme	species	183:189	arg1	effects					153:159	the effects	149:159	the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution	149:321	This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution.
33453250	0	57	theme	Cr	75:76	arg1	removal					82:88	enhanced Cr(VI) removal	66:88	enhanced Cr(VI) removal from aqueous solution	66:110	Iron oxides decorated graphene oxide/chitosan composite beads for enhanced Cr(VI) removal from aqueous solution.
33453250	0	58	theme	enhanced	66:73	arg1	removal					82:88	enhanced Cr(VI) removal	66:88	enhanced Cr(VI) removal from aqueous solution	66:110	Iron oxides decorated graphene oxide/chitosan composite beads for enhanced Cr(VI) removal from aqueous solution.
33453250	5	59	theme	Cr	925:926	arg1	concentration					932:944	the increasing initial Cr(VI) concentration	902:944	the increasing initial Cr(VI) concentration	902:944	Qe increases with the increasing initial Cr(VI) concentration, contact time, and temperature, while decreases with the increasing pH and mass and volume ratio (m/v).
33453250	8	60	theme	regeneration	1272:1283	arg1	times					1263:1267	five times	1258:1267	five times of regeneration	1258:1283	After five times of regeneration, Re is still as high as 84% and Qe drops about 2.6%.
33453250	4	61	theme	surface	805:811	arg1	-NH3+					813:817	surface -NH3+	805:817	surface -NH3+	805:817	It is found that Cr(VI) removal mainly includes electrostatic attraction between Cr(VI) oxyanions and surface -NH3+ and -OH2+, and the adsorbed Cr(VI) partially reduces to Cr(III).
33453250	8	62	theme	Qe	1317:1318	arg1	drops					1320:1324	Qe drops	1317:1324	Qe drops	1317:1324	After five times of regeneration, Re is still as high as 84% and Qe drops about 2.6%.
33453250	0	63	from	solution	103:110	arg1	removal					82:88	enhanced Cr(VI) removal	66:88	enhanced Cr(VI) removal from aqueous solution	66:110	Iron oxides decorated graphene oxide/chitosan composite beads for enhanced Cr(VI) removal from aqueous solution.
33636644	0	0	theme	major	133:137	arg1	study					16:20	A comprehensive study	0:20	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B	0:112	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	0	0	theme	major	133:137	arg1	component					149:157	a major bioactive component	131:157	a major bioactive component form Oroxylum indicum (L.) Vent	131:189	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	6	1	theme	other	927:931	arg1	conjugation					1039:1049	glycine conjugation	1031:1049	glycine conjugation	1031:1049	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	1	theme	other	927:931	arg1	reactions					1096:1104	their composite reactions	1080:1104	their composite reactions	1080:1104	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	1	theme	other	927:931	arg1	hydrolysis					985:994	internal hydrolysis	976:994	internal hydrolysis	976:994	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	1	theme	other	927:931	arg1	ketone					1023:1028	ketone	1023:1028	ketone	1023:1028	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	1	theme	other	927:931	arg1	oxidation					952:960	oxidation	952:960	oxidation	952:960	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	1	theme	other	927:931	arg1	conjugation					1064:1074	glucuronide conjugation	1052:1074	glucuronide conjugation	1052:1074	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	1	theme	other	927:931	arg1	hydrogenation					997:1009	hydrogenation	997:1009	hydrogenation	997:1009	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	1	theme	other	927:931	arg1	methylation					963:973	methylation	963:973	methylation	963:973	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	1	theme	other	927:931	arg1	loss					1012:1015	loss	1012:1015	loss of O	1012:1020	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	1	theme	other	927:931	arg1	reactions					933:941	some other reactions	922:941	some other reactions	922:941	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	2	theme	O	1020:1020	arg1	conjugation					1039:1049	glycine conjugation	1031:1049	glycine conjugation	1031:1049	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	2	theme	O	1020:1020	arg1	reactions					1096:1104	their composite reactions	1080:1104	their composite reactions	1080:1104	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	2	theme	O	1020:1020	arg1	hydrolysis					985:994	internal hydrolysis	976:994	internal hydrolysis	976:994	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	2	theme	O	1020:1020	arg1	ketone					1023:1028	ketone	1023:1028	ketone	1023:1028	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	2	theme	O	1020:1020	arg1	oxidation					952:960	oxidation	952:960	oxidation	952:960	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	2	theme	O	1020:1020	arg1	conjugation					1064:1074	glucuronide conjugation	1052:1074	glucuronide conjugation	1052:1074	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	2	theme	O	1020:1020	arg1	hydrogenation					997:1009	hydrogenation	997:1009	hydrogenation	997:1009	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	2	theme	O	1020:1020	arg1	methylation					963:973	methylation	963:973	methylation	963:973	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	2	theme	O	1020:1020	arg1	loss					1012:1015	loss	1012:1015	loss of O	1012:1020	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	1	3	theme	enormous	197:204	arg1	effects					220:226	enormous anti-hepatoma effects	197:226	enormous anti-hepatoma effects	197:226	with enormous anti-hepatoma effects.
33636644	5	4	theme	biotransformation	697:713	arg1	processes					715:723	The biotransformation processes	693:723	The biotransformation processes	693:723	The biotransformation processes involved ketone, acetylation, loss of C12H20O10, and loss of C6H10O5.
33636644	1	5	theme	anti-hepatoma	206:218	arg1	effects					220:226	enormous anti-hepatoma effects	197:226	enormous anti-hepatoma effects	197:226	with enormous anti-hepatoma effects.
33636644	6	6	theme	composite	1086:1094	arg1	reactions					1096:1104	their composite reactions	1080:1104	their composite reactions	1080:1104	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	4	7	with	comparison	666:675	arg1	standards					682:690	standards	682:690	standards	682:690	Consequently, 30 metabolites in rats, 8 metabolites in liver microsomes and 18 metabolites in intestinal bacteria were identified, and 9 metabolites were recognized by comparison with standards.
33636644	0	8	theme	bioactive	139:147	arg1	study					16:20	A comprehensive study	0:20	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B	0:112	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	0	8	theme	bioactive	139:147	arg1	component					149:157	a major bioactive component	131:157	a major bioactive component form Oroxylum indicum (L.) Vent	131:189	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	4	9	theme	liver	553:557	arg1	microsomes					559:568	liver microsomes	553:568	liver microsomes	553:568	Consequently, 30 metabolites in rats, 8 metabolites in liver microsomes and 18 metabolites in intestinal bacteria were identified, and 9 metabolites were recognized by comparison with standards.
33636644	6	10	theme	glucuronide	1052:1062	arg1	conjugation					1064:1074	glucuronide conjugation	1052:1074	glucuronide conjugation	1052:1074	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	7	11	theme	further	1257:1263	arg1	efficacy					1303:1310	efficacy	1303:1310	efficacy	1303:1310	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	7	11	theme	further	1257:1263	arg1	safety					1292:1297	safety	1292:1297	safety	1292:1297	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	7	11	theme	further	1257:1263	arg1	investigations					1265:1278	further investigations	1257:1278	further investigations of oroxin B safety and efficacy	1257:1310	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	7	12	theme	oroxin	1283:1288	arg1	B					1290:1290	oroxin B	1283:1290	oroxin B	1283:1290	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	4	13	from	metabolites	538:548	arg1	rats					530:533	rats	530:533	rats	530:533	Consequently, 30 metabolites in rats, 8 metabolites in liver microsomes and 18 metabolites in intestinal bacteria were identified, and 9 metabolites were recognized by comparison with standards.
33636644	4	13	from	metabolites	538:548	arg1	microsomes					559:568	liver microsomes	553:568	liver microsomes	553:568	Consequently, 30 metabolites in rats, 8 metabolites in liver microsomes and 18 metabolites in intestinal bacteria were identified, and 9 metabolites were recognized by comparison with standards.
33636644	4	13	from	metabolites	538:548	arg1	bacteria					603:610	intestinal bacteria	592:610	intestinal bacteria	592:610	Consequently, 30 metabolites in rats, 8 metabolites in liver microsomes and 18 metabolites in intestinal bacteria were identified, and 9 metabolites were recognized by comparison with standards.
33636644	4	14	from	metabolites	515:525	arg1	rats					530:533	rats	530:533	rats	530:533	Consequently, 30 metabolites in rats, 8 metabolites in liver microsomes and 18 metabolites in intestinal bacteria were identified, and 9 metabolites were recognized by comparison with standards.
33636644	4	14	from	metabolites	515:525	arg1	microsomes					559:568	liver microsomes	553:568	liver microsomes	553:568	Consequently, 30 metabolites in rats, 8 metabolites in liver microsomes and 18 metabolites in intestinal bacteria were identified, and 9 metabolites were recognized by comparison with standards.
33636644	4	14	from	metabolites	515:525	arg1	bacteria					603:610	intestinal bacteria	592:610	intestinal bacteria	592:610	Consequently, 30 metabolites in rats, 8 metabolites in liver microsomes and 18 metabolites in intestinal bacteria were identified, and 9 metabolites were recognized by comparison with standards.
33636644	3	15	theme	ultrahigh-performance	376:396	arg1	chromatography					405:418	ultrahigh-performance liquid chromatography	376:418	ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS)	376:495	This study was designed to characterize oroxin B metabolism in vivo and in vitro by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS).
33636644	0	16	theme	comprehensive	2:14	arg1	study					16:20	A comprehensive study	0:20	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B	0:112	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	0	16	theme	comprehensive	2:14	arg1	flavonoid					117:125	a flavonoid	115:125	a flavonoid	115:125	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	0	16	theme	comprehensive	2:14	arg1	component					149:157	a major bioactive component	131:157	a major bioactive component form Oroxylum indicum (L.) Vent	131:189	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	7	17	theme	reasonable	1231:1240	arg1	guidelines					1242:1251	reasonable guidelines	1231:1251	reasonable guidelines for further investigations of oroxin B safety and efficacy	1231:1310	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	7	18	theme	potential	1165:1173	arg1	mechanism					1175:1183	the potential mechanism	1161:1183	elucidation the potential mechanism of oroxin B pharmacological action	1149:1218	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	2	19	theme	metabolism	251:260	arg1	studies					262:268	the oroxin B metabolism studies	238:268	the oroxin B metabolism studies	238:268	To data, the oroxin B metabolism studies remain underexplored.
33636644	6	20	theme	C12H20O10	851:859	arg1	loss					866:869	loss	866:869	loss of C6H10O5	866:880	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	20	theme	C12H20O10	851:859	arg1	loss					843:846	loss	843:846	loss of C12H20O10	843:859	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	3	21	theme	B	339:339	arg1	metabolism					341:350	oroxin B metabolism	332:350	oroxin B metabolism	332:350	This study was designed to characterize oroxin B metabolism in vivo and in vitro by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS).
33636644	0	22	theme	indicum	173:179	arg1	Vent					186:189	Oroxylum indicum (L.) Vent	164:189	Oroxylum indicum (L.) Vent	164:189	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	2	23	theme	B	249:249	arg1	studies					262:268	the oroxin B metabolism studies	238:268	the oroxin B metabolism studies	238:268	To data, the oroxin B metabolism studies remain underexplored.
33636644	5	24	theme	C6H10O5	786:792	arg1	acetylation					742:752	acetylation	742:752	acetylation	742:752	The biotransformation processes involved ketone, acetylation, loss of C12H20O10, and loss of C6H10O5.
33636644	5	24	theme	C6H10O5	786:792	arg1	ketone					734:739	ketone	734:739	ketone	734:739	The biotransformation processes involved ketone, acetylation, loss of C12H20O10, and loss of C6H10O5.
33636644	5	24	theme	C6H10O5	786:792	arg1	loss					778:781	loss	778:781	loss of C6H10O5	778:792	The biotransformation processes involved ketone, acetylation, loss of C12H20O10, and loss of C6H10O5.
33636644	5	24	theme	C6H10O5	786:792	arg1	loss					755:758	loss	755:758	loss of C12H20O10	755:771	The biotransformation processes involved ketone, acetylation, loss of C12H20O10, and loss of C6H10O5.
33636644	0	25	theme	Oroxin	105:110	arg1	B					112:112	UHPLC-Q-TOF-MS/MS. Oroxin B	86:112	UHPLC-Q-TOF-MS/MS. Oroxin B	86:112	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	2	26	theme	oroxin	242:247	arg1	studies					262:268	the oroxin B metabolism studies	238:268	the oroxin B metabolism studies	238:268	To data, the oroxin B metabolism studies remain underexplored.
33636644	6	27	theme	glycine	1031:1037	arg1	conjugation					1039:1049	glycine conjugation	1031:1049	glycine conjugation	1031:1049	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	0	28	theme	UHPLC-Q-TOF-MS/MS.	86:103	arg1	B					112:112	UHPLC-Q-TOF-MS/MS. Oroxin B	86:112	UHPLC-Q-TOF-MS/MS. Oroxin B	86:112	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	7	29	theme	oroxin	1188:1193	arg1	B					1195:1195	oroxin B	1188:1195	oroxin B pharmacological action	1188:1218	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	4	30	theme	intestinal	592:601	arg1	bacteria					603:610	intestinal bacteria	592:610	intestinal bacteria	592:610	Consequently, 30 metabolites in rats, 8 metabolites in liver microsomes and 18 metabolites in intestinal bacteria were identified, and 9 metabolites were recognized by comparison with standards.
33636644	0	31	theme	metabolism	29:38	arg1	study					16:20	A comprehensive study	0:20	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B	0:112	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	0	31	theme	metabolism	29:38	arg1	flavonoid					117:125	a flavonoid	115:125	a flavonoid	115:125	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	0	31	theme	metabolism	29:38	arg1	component					149:157	a major bioactive component	131:157	a major bioactive component form Oroxylum indicum (L.) Vent	131:189	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	6	32	theme	internal	976:983	arg1	hydrolysis					985:994	internal hydrolysis	976:994	internal hydrolysis	976:994	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	7	33	dep	investigations	1265:1278	arg1	efficacy					1303:1310	efficacy	1303:1310	efficacy	1303:1310	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	7	33	dep	investigations	1265:1278	arg1	safety					1292:1297	safety	1292:1297	safety	1292:1297	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	7	33	dep	investigations	1265:1278	arg1	investigations					1265:1278	further investigations	1257:1278	further investigations of oroxin B safety and efficacy	1257:1310	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	3	34	theme	liquid	398:403	arg1	chromatography					405:418	ultrahigh-performance liquid chromatography	376:418	ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS)	376:495	This study was designed to characterize oroxin B metabolism in vivo and in vitro by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS).
33636644	5	35	theme	C12H20O10	763:771	arg1	acetylation					742:752	acetylation	742:752	acetylation	742:752	The biotransformation processes involved ketone, acetylation, loss of C12H20O10, and loss of C6H10O5.
33636644	5	35	theme	C12H20O10	763:771	arg1	ketone					734:739	ketone	734:739	ketone	734:739	The biotransformation processes involved ketone, acetylation, loss of C12H20O10, and loss of C6H10O5.
33636644	5	35	theme	C12H20O10	763:771	arg1	loss					778:781	loss	778:781	loss of C6H10O5	778:792	The biotransformation processes involved ketone, acetylation, loss of C12H20O10, and loss of C6H10O5.
33636644	5	35	theme	C12H20O10	763:771	arg1	loss					755:758	loss	755:758	loss of C12H20O10	755:771	The biotransformation processes involved ketone, acetylation, loss of C12H20O10, and loss of C6H10O5.
33636644	7	36	theme	valuable	1127:1134	arg1	evidence					1136:1143	valuable evidence	1127:1143	valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action	1127:1218	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	0	37	theme	flavonoid	43:51	arg1	B					60:60	flavonoid oroxin B	43:60	flavonoid oroxin B	43:60	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	4	38	from	metabolites	577:587	arg1	rats					530:533	rats	530:533	rats	530:533	Consequently, 30 metabolites in rats, 8 metabolites in liver microsomes and 18 metabolites in intestinal bacteria were identified, and 9 metabolites were recognized by comparison with standards.
33636644	4	38	from	metabolites	577:587	arg1	microsomes					559:568	liver microsomes	553:568	liver microsomes	553:568	Consequently, 30 metabolites in rats, 8 metabolites in liver microsomes and 18 metabolites in intestinal bacteria were identified, and 9 metabolites were recognized by comparison with standards.
33636644	4	38	from	metabolites	577:587	arg1	bacteria					603:610	intestinal bacteria	592:610	intestinal bacteria	592:610	Consequently, 30 metabolites in rats, 8 metabolites in liver microsomes and 18 metabolites in intestinal bacteria were identified, and 9 metabolites were recognized by comparison with standards.
33636644	3	39	theme	mass	459:462	arg1	UHPLC-Q-TOF-MS/MS					478:494	UHPLC-Q-TOF-MS/MS	478:494	UHPLC-Q-TOF-MS/MS	478:494	This study was designed to characterize oroxin B metabolism in vivo and in vitro by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS).
33636644	3	39	theme	mass	459:462	arg1	spectrometry					464:475	quadrupole time-of-flight mass spectrometry	433:475	quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS)	433:495	This study was designed to characterize oroxin B metabolism in vivo and in vitro by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS).
33636644	7	40	dep	elucidation	1149:1159	arg1	mechanism					1175:1183	the potential mechanism	1161:1183	elucidation the potential mechanism of oroxin B pharmacological action	1149:1218	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	6	41	theme	oroxin	813:818	arg1	A					820:820	oroxin A	813:820	oroxin A	813:820	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	7	42	theme	B	1290:1290	arg1	efficacy					1303:1310	efficacy	1303:1310	efficacy	1303:1310	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	7	42	theme	B	1290:1290	arg1	safety					1292:1297	safety	1292:1297	safety	1292:1297	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	7	42	theme	B	1290:1290	arg1	investigations					1265:1278	further investigations	1257:1278	further investigations of oroxin B safety and efficacy	1257:1310	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	7	43	theme	pharmacological	1197:1211	arg1	action					1213:1218	oroxin B pharmacological action	1188:1218	oroxin B pharmacological action	1188:1218	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	3	44	theme	quadrupole	433:442	arg1	UHPLC-Q-TOF-MS/MS					478:494	UHPLC-Q-TOF-MS/MS	478:494	UHPLC-Q-TOF-MS/MS	478:494	This study was designed to characterize oroxin B metabolism in vivo and in vitro by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS).
33636644	3	44	theme	quadrupole	433:442	arg1	spectrometry					464:475	quadrupole time-of-flight mass spectrometry	433:475	quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS)	433:495	This study was designed to characterize oroxin B metabolism in vivo and in vitro by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS).
33636644	3	45	theme	time-of-flight	444:457	arg1	UHPLC-Q-TOF-MS/MS					478:494	UHPLC-Q-TOF-MS/MS	478:494	UHPLC-Q-TOF-MS/MS	478:494	This study was designed to characterize oroxin B metabolism in vivo and in vitro by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS).
33636644	3	45	theme	time-of-flight	444:457	arg1	spectrometry					464:475	quadrupole time-of-flight mass spectrometry	433:475	quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS)	433:495	This study was designed to characterize oroxin B metabolism in vivo and in vitro by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS).
33636644	7	46	theme	action	1213:1218	arg1	mechanism					1175:1183	the potential mechanism	1161:1183	elucidation the potential mechanism of oroxin B pharmacological action	1149:1218	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	0	47	theme	B	60:60	arg1	metabolism					29:38	the metabolism	25:38	the metabolism of flavonoid oroxin B	25:60	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	7	48	theme	B	1195:1195	arg1	action					1213:1218	oroxin B pharmacological action	1188:1218	oroxin B pharmacological action	1188:1218	The results provide valuable evidence for elucidation the potential mechanism of oroxin B pharmacological action, and offer reasonable guidelines for further investigations of oroxin B safety and efficacy.
33636644	0	49	dep	indicum	173:179	arg1	L.					182:183	L.	182:183	L.	182:183	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	0	50	theme	oroxin	53:58	arg1	B					60:60	flavonoid oroxin B	43:60	flavonoid oroxin B	43:60	A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS. Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent.
33636644	6	51	theme	C6H10O5	874:880	arg1	loss					866:869	loss	866:869	loss of C6H10O5	866:880	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	6	51	theme	C6H10O5	874:880	arg1	loss					843:846	loss	843:846	loss of C12H20O10	843:859	And baicalein and oroxin A were generated after loss of C12H20O10, and loss of C6H10O5, respectively, and further went through some other reactions, such as oxidation, methylation, internal hydrolysis, hydrogenation, loss of O, ketone, glycine conjugation, glucuronide conjugation and their composite reactions.
33636644	3	52	theme	oroxin	332:337	arg1	metabolism					341:350	oroxin B metabolism	332:350	oroxin B metabolism	332:350	This study was designed to characterize oroxin B metabolism in vivo and in vitro by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS).
31996289	7	0	theme	average	1257:1263	arg1	reduction					1282:1290	viscosity average molecular weight reduction	1247:1290	viscosity average molecular weight reduction	1247:1290	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	12	1	theme	small-diameter	1818:1831	arg1	vessels					1839:1845	biodegradable small-diameter blood vessels	1804:1845	biodegradable small-diameter blood vessels	1804:1845	In conclusion, we successfully obtained biodegradable small-diameter blood vessels through electrospinning PLLA/PVP and modifying this blend's surface using ESA.
31996289	4	2	theme	PLLA/PVP	621:628	arg1	films					630:634	PLLA/PVP films	621:634	PLLA/PVP films	621:634	The characteristics of PLLA/PVP films were investigated by scanning electron microscopy (SEM), contact angle measurement and mechanical property testing.
31996289	7	3	from	reduction	1282:1290	arg1	solutions					1322:1330	the testing solutions	1310:1330	the testing solutions	1310:1330	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	13	4	theme	improved	2018:2025	arg1	properties					2057:2066	improved hydrophilic and anticoagulant properties	2018:2066	improved hydrophilic and anticoagulant properties	2018:2066	The study provided a feasible method for making small-diameter synthetic blood vessels with improved hydrophilic and anticoagulant properties.
31996289	5	5	theme	smooth	856:861	arg1	VSMCs					877:881	VSMCs	877:881	VSMCs	877:881	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	5	5	theme	smooth	856:861	arg1	cells					870:874	vascular smooth muscle cells	847:874	vascular smooth muscle cells (VSMCs) proliferation	847:896	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	1	6	theme	blood	209:213	arg1	vessels					215:221	Large (> 6 mm) artificial blood vessels	183:221	Large (> 6 mm) artificial blood vessels	183:221	Large (> 6 mm) artificial blood vessels have been successfully employed in clinic practice.
31996289	1	6	theme	blood	209:213	arg1	mm					194:195	> 6 mm	190:195	> 6 mm	190:195	Large (> 6 mm) artificial blood vessels have been successfully employed in clinic practice.
31996289	4	7	theme	contact	693:699	arg1	measurement					707:717	contact angle measurement	693:717	contact angle measurement	693:717	The characteristics of PLLA/PVP films were investigated by scanning electron microscopy (SEM), contact angle measurement and mechanical property testing.
31996289	5	8	theme	platelet	902:909	arg1	adhesion					911:918	platelet adhesion	902:918	platelet adhesion	902:918	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	9	9	theme	electrospun	1475:1485	arg1	films					1487:1491	electrospun films	1475:1491	electrospun films with PVP	1475:1500	The results of these experiments showed that electrospun films with PVP possessed a good structure and improved hydrophilicity.
31996289	7	10	from	change	1300:1305	arg1	solutions					1322:1330	the testing solutions	1310:1330	the testing solutions	1310:1330	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	4	11	theme	electron	666:673	arg1	microscopy					675:684	scanning electron microscopy	657:684	scanning electron microscopy (SEM)	657:690	The characteristics of PLLA/PVP films were investigated by scanning electron microscopy (SEM), contact angle measurement and mechanical property testing.
31996289	4	11	theme	electron	666:673	arg1	SEM					687:689	SEM	687:689	SEM	687:689	The characteristics of PLLA/PVP films were investigated by scanning electron microscopy (SEM), contact angle measurement and mechanical property testing.
31996289	10	12	theme	blood	1659:1663	arg1	compatibilities					1665:1679	excellent blood compatibilities	1649:1679	excellent blood compatibilities	1649:1679	The films assembled with chitosan/heparin by ESA were beneficial to VSMCs survival and had excellent blood compatibilities.
31996289	5	13	theme	muscle	863:868	arg1	VSMCs					877:881	VSMCs	877:881	VSMCs	877:881	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	5	13	theme	muscle	863:868	arg1	cells					870:874	vascular smooth muscle cells	847:874	vascular smooth muscle cells (VSMCs) proliferation	847:896	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	9	14	theme	good	1514:1517	arg1	structure					1519:1527	a good structure	1512:1527	a good structure	1512:1527	The results of these experiments showed that electrospun films with PVP possessed a good structure and improved hydrophilicity.
31996289	5	15	dep	cytocompatiblility	756:773	arg1	The					752:754	The	752:754	The	752:754	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	7	16	from	loss	1241:1244	arg1	solutions					1322:1330	the testing solutions	1310:1330	the testing solutions	1310:1330	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	13	17	theme	blood	1999:2003	arg1	vessels					2005:2011	small-diameter synthetic blood vessels	1974:2011	small-diameter synthetic blood vessels	1974:2011	The study provided a feasible method for making small-diameter synthetic blood vessels with improved hydrophilic and anticoagulant properties.
31996289	3	18	theme	electrostatic	563:575	arg1	ESA					592:594	ESA	592:594	ESA	592:594	In this study, poly-vinylpyrrolidone (PVP) was introduced into poly-L-lactic acid (PLLA) to prepare biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA).
31996289	3	18	theme	electrostatic	563:575	arg1	self-assembly					577:589	electrostatic self-assembly	563:589	electrostatic self-assembly (ESA)	563:595	In this study, poly-vinylpyrrolidone (PVP) was introduced into poly-L-lactic acid (PLLA) to prepare biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA).
31996289	6	19	theme	fiber	1069:1073	arg1	films					1075:1079	ESA-modified electrospun fiber films	1044:1079	ESA-modified electrospun fiber films	1044:1079	Next, the surface of ESA-modified electrospun fiber films was analyzed through SEM and photoelectron spectroscopy (XPS).
31996289	7	20	theme	viscosity	1247:1255	arg1	reduction					1282:1290	viscosity average molecular weight reduction	1247:1290	viscosity average molecular weight reduction	1247:1290	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	7	21	theme	films	1185:1189	arg1	characteristics					1160:1174	The degradation characteristics	1144:1174	The degradation characteristics of these films	1144:1189	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	7	21	theme	films	1185:1189	arg1	well					1335:1338	well	1335:1338	well	1335:1338	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	4	22	theme	mechanical	723:732	arg1	testing					743:749	mechanical property testing	723:749	mechanical property testing	723:749	The characteristics of PLLA/PVP films were investigated by scanning electron microscopy (SEM), contact angle measurement and mechanical property testing.
31996289	0	23	theme	Potential	116:124	arg1	Applications					126:137	Its Potential Applications	112:137	Its Potential Applications in Small-Diameter Artificial Blood Vessels	112:180	Electrostatic Self-Assemble Modified Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer and Its Potential Applications in Small-Diameter Artificial Blood Vessels.
31996289	5	24	from	morphology	929:938	arg1	films					952:956	films	952:956	films	952:956	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	13	25	theme	small-diameter	1974:1987	arg1	vessels					2005:2011	small-diameter synthetic blood vessels	1974:2011	small-diameter synthetic blood vessels	1974:2011	The study provided a feasible method for making small-diameter synthetic blood vessels with improved hydrophilic and anticoagulant properties.
31996289	9	26	contain	possessed	1502:1510	arg1	films					1487:1491	electrospun films	1475:1491	electrospun films with PVP	1475:1500	The results of these experiments showed that electrospun films with PVP possessed a good structure and improved hydrophilicity.
31996289	9	26	contain	possessed	1502:1510	arg2	structure					1519:1527	a good structure	1512:1527	a good structure	1512:1527	The results of these experiments showed that electrospun films with PVP possessed a good structure and improved hydrophilicity.
31996289	0	27	theme	Artificial	157:166	arg1	Vessels					174:180	Small-Diameter Artificial Blood Vessels	142:180	Small-Diameter Artificial Blood Vessels	142:180	Electrostatic Self-Assemble Modified Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer and Its Potential Applications in Small-Diameter Artificial Blood Vessels.
31996289	13	28	theme	feasible	1947:1954	arg1	method					1956:1961	a feasible method	1945:1961	a feasible method for making small-diameter synthetic blood vessels with improved hydrophilic and anticoagulant properties	1945:2066	The study provided a feasible method for making small-diameter synthetic blood vessels with improved hydrophilic and anticoagulant properties.
31996289	0	29	theme	Electrostatic	0:12	arg1	Self-Assemble					14:26	Electrostatic Self-Assemble	0:26	Electrostatic Self-Assemble	0:26	Electrostatic Self-Assemble Modified Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer and Its Potential Applications in Small-Diameter Artificial Blood Vessels.
31996289	6	30	theme	films	1075:1079	arg1	surface					1033:1039	the surface	1029:1039	the surface of ESA-modified electrospun fiber films	1029:1079	Next, the surface of ESA-modified electrospun fiber films was analyzed through SEM and photoelectron spectroscopy (XPS).
31996289	5	31	theme	cells	870:874	arg1	proliferation					884:896	vascular smooth muscle cells (VSMCs) proliferation	847:896	vascular smooth muscle cells (VSMCs) proliferation	847:896	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	5	32	theme	scanning	978:985	arg1	microscopy					996:1005	laser scanning confocal microscopy	972:1005	laser scanning confocal microscopy (LSCM)	972:1012	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	5	32	theme	scanning	978:985	arg1	LSCM					1008:1011	LSCM	1008:1011	LSCM	1008:1011	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	6	33	theme	electrospun	1057:1067	arg1	films					1075:1079	ESA-modified electrospun fiber films	1044:1079	ESA-modified electrospun fiber films	1044:1079	Next, the surface of ESA-modified electrospun fiber films was analyzed through SEM and photoelectron spectroscopy (XPS).
31996289	9	34	with	films	1487:1491	arg1	PVP					1498:1500	PVP	1498:1500	PVP	1498:1500	The results of these experiments showed that electrospun films with PVP possessed a good structure and improved hydrophilicity.
31996289	0	35	theme	Poly-L-Lactic	49:61	arg1	Polymer					100:106	Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer	37:106	Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer	37:106	Electrostatic Self-Assemble Modified Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer and Its Potential Applications in Small-Diameter Artificial Blood Vessels.
31996289	11	36	theme	good	1737:1740	arg1	compatibility					1749:1761	good tissue compatibility	1737:1761	good tissue compatibility	1737:1761	The data indicated these films were biodegradable with good tissue compatibility.
31996289	3	37	theme	electrospun	505:515	arg1	vessels					523:529	biodegradable small-diameter electrospun blood vessels	476:529	biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA)	476:595	In this study, poly-vinylpyrrolidone (PVP) was introduced into poly-L-lactic acid (PLLA) to prepare biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA).
31996289	7	38	theme	degradation	1148:1158	arg1	characteristics					1160:1174	The degradation characteristics	1144:1174	The degradation characteristics of these films	1144:1189	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	7	38	theme	degradation	1148:1158	arg1	well					1335:1338	well	1335:1338	well	1335:1338	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	3	39	theme	biodegradable	476:488	arg1	vessels					523:529	biodegradable small-diameter electrospun blood vessels	476:529	biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA)	476:595	In this study, poly-vinylpyrrolidone (PVP) was introduced into poly-L-lactic acid (PLLA) to prepare biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA).
31996289	1	40	theme	clinic	258:263	arg1	practice					265:272	clinic practice	258:272	clinic practice	258:272	Large (> 6 mm) artificial blood vessels have been successfully employed in clinic practice.
31996289	4	41	theme	films	630:634	arg1	characteristics					602:616	The characteristics	598:616	The characteristics of PLLA/PVP films	598:634	The characteristics of PLLA/PVP films were investigated by scanning electron microscopy (SEM), contact angle measurement and mechanical property testing.
31996289	11	42	with	biodegradable	1718:1730	arg1	compatibility					1749:1761	good tissue compatibility	1737:1761	good tissue compatibility	1737:1761	The data indicated these films were biodegradable with good tissue compatibility.
31996289	6	43	theme	photoelectron	1110:1122	arg1	XPS					1138:1140	XPS	1138:1140	XPS	1138:1140	Next, the surface of ESA-modified electrospun fiber films was analyzed through SEM and photoelectron spectroscopy (XPS).
31996289	6	43	theme	photoelectron	1110:1122	arg1	spectroscopy					1124:1135	photoelectron spectroscopy	1110:1135	photoelectron spectroscopy (XPS)	1110:1141	Next, the surface of ESA-modified electrospun fiber films was analyzed through SEM and photoelectron spectroscopy (XPS).
31996289	7	44	theme	weight	1234:1239	arg1	loss					1241:1244	weight loss	1234:1244	weight loss	1234:1244	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	12	45	theme	blood	1833:1837	arg1	vessels					1839:1845	biodegradable small-diameter blood vessels	1804:1845	biodegradable small-diameter blood vessels	1804:1845	In conclusion, we successfully obtained biodegradable small-diameter blood vessels through electrospinning PLLA/PVP and modifying this blend's surface using ESA.
31996289	7	46	theme	molecular	1265:1273	arg1	reduction					1282:1290	viscosity average molecular weight reduction	1247:1290	viscosity average molecular weight reduction	1247:1290	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	10	47	theme	beneficial	1612:1621	arg1	survival					1632:1639	beneficial to VSMCs survival	1612:1639	beneficial to VSMCs survival	1612:1639	The films assembled with chitosan/heparin by ESA were beneficial to VSMCs survival and had excellent blood compatibilities.
31996289	10	47	theme	beneficial	1612:1621	arg1	films					1562:1566	The films	1558:1566	The films assembled with chitosan/heparin by ESA	1558:1605	The films assembled with chitosan/heparin by ESA were beneficial to VSMCs survival and had excellent blood compatibilities.
31996289	2	48	theme	synthetic	308:316	arg1	grafts					318:323	small-diameter (< 6 mm) synthetic grafts	284:323	small-diameter (< 6 mm) synthetic grafts	284:323	However, small-diameter (< 6 mm) synthetic grafts have not been applied due to their hydrophobicity.
31996289	1	49	theme	artificial	198:207	arg1	vessels					215:221	Large (> 6 mm) artificial blood vessels	183:221	Large (> 6 mm) artificial blood vessels	183:221	Large (> 6 mm) artificial blood vessels have been successfully employed in clinic practice.
31996289	1	49	theme	artificial	198:207	arg1	mm					194:195	> 6 mm	190:195	> 6 mm	190:195	Large (> 6 mm) artificial blood vessels have been successfully employed in clinic practice.
31996289	0	50	theme	Composite	90:98	arg1	Polymer					100:106	Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer	37:106	Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer	37:106	Electrostatic Self-Assemble Modified Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer and Its Potential Applications in Small-Diameter Artificial Blood Vessels.
31996289	5	51	theme	films	812:816	arg1	cytocompatiblility					756:773	cytocompatiblility	756:773	cytocompatiblility	756:773	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	5	51	theme	films	812:816	arg1	compatibility					785:797	blood compatibility	779:797	blood compatibility	779:797	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	13	52	theme	hydrophilic	2027:2037	arg1	properties					2057:2066	improved hydrophilic and anticoagulant properties	2018:2066	improved hydrophilic and anticoagulant properties	2018:2066	The study provided a feasible method for making small-diameter synthetic blood vessels with improved hydrophilic and anticoagulant properties.
31996289	12	53	theme	biodegradable	1804:1816	arg1	vessels					1839:1845	biodegradable small-diameter blood vessels	1804:1845	biodegradable small-diameter blood vessels	1804:1845	In conclusion, we successfully obtained biodegradable small-diameter blood vessels through electrospinning PLLA/PVP and modifying this blend's surface using ESA.
31996289	13	54	theme	anticoagulant	2043:2055	arg1	properties					2057:2066	improved hydrophilic and anticoagulant properties	2018:2066	improved hydrophilic and anticoagulant properties	2018:2066	The study provided a feasible method for making small-diameter synthetic blood vessels with improved hydrophilic and anticoagulant properties.
31996289	0	55	from	Applications	126:137	arg1	Vessels					174:180	Small-Diameter Artificial Blood Vessels	142:180	Small-Diameter Artificial Blood Vessels	142:180	Electrostatic Self-Assemble Modified Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer and Its Potential Applications in Small-Diameter Artificial Blood Vessels.
31996289	4	56	theme	scanning	657:664	arg1	microscopy					675:684	scanning electron microscopy	657:684	scanning electron microscopy (SEM)	657:690	The characteristics of PLLA/PVP films were investigated by scanning electron microscopy (SEM), contact angle measurement and mechanical property testing.
31996289	4	56	theme	scanning	657:664	arg1	SEM					687:689	SEM	687:689	SEM	687:689	The characteristics of PLLA/PVP films were investigated by scanning electron microscopy (SEM), contact angle measurement and mechanical property testing.
31996289	7	57	from	observation	1221:1231	arg1	solutions					1322:1330	the testing solutions	1310:1330	the testing solutions	1310:1330	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	10	58	theme	excellent	1649:1657	arg1	compatibilities					1665:1679	excellent blood compatibilities	1649:1679	excellent blood compatibilities	1649:1679	The films assembled with chitosan/heparin by ESA were beneficial to VSMCs survival and had excellent blood compatibilities.
31996289	9	59	theme	experiments	1451:1461	arg1	results					1434:1440	The results	1430:1440	The results of these experiments	1430:1461	The results of these experiments showed that electrospun films with PVP possessed a good structure and improved hydrophilicity.
31996289	5	60	theme	cells	943:947	arg1	morphology					929:938	the morphology	925:938	the morphology of cells on films	925:956	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	4	61	theme	property	734:741	arg1	testing					743:749	mechanical property testing	723:749	mechanical property testing	723:749	The characteristics of PLLA/PVP films were investigated by scanning electron microscopy (SEM), contact angle measurement and mechanical property testing.
31996289	13	62	theme	synthetic	1989:1997	arg1	vessels					2005:2011	small-diameter synthetic blood vessels	1974:2011	small-diameter synthetic blood vessels	1974:2011	The study provided a feasible method for making small-diameter synthetic blood vessels with improved hydrophilic and anticoagulant properties.
31996289	2	63	theme	<	300:300	arg1	small-diameter					284:297	small-diameter	284:297	small-diameter (< 6 mm) synthetic grafts	284:323	However, small-diameter (< 6 mm) synthetic grafts have not been applied due to their hydrophobicity.
31996289	2	63	theme	<	300:300	arg1	mm					304:305	< 6 mm	300:305	< 6 mm	300:305	However, small-diameter (< 6 mm) synthetic grafts have not been applied due to their hydrophobicity.
31996289	1	64	theme	Large	183:187	arg1	vessels					215:221	Large (> 6 mm) artificial blood vessels	183:221	Large (> 6 mm) artificial blood vessels	183:221	Large (> 6 mm) artificial blood vessels have been successfully employed in clinic practice.
31996289	1	64	theme	Large	183:187	arg1	mm					194:195	> 6 mm	190:195	> 6 mm	190:195	Large (> 6 mm) artificial blood vessels have been successfully employed in clinic practice.
31996289	2	65	theme	small-diameter	284:297	arg1	grafts					318:323	small-diameter (< 6 mm) synthetic grafts	284:323	small-diameter (< 6 mm) synthetic grafts	284:323	However, small-diameter (< 6 mm) synthetic grafts have not been applied due to their hydrophobicity.
31996289	1	66	theme	>	190:190	arg1	vessels					215:221	Large (> 6 mm) artificial blood vessels	183:221	Large (> 6 mm) artificial blood vessels	183:221	Large (> 6 mm) artificial blood vessels have been successfully employed in clinic practice.
31996289	1	66	theme	>	190:190	arg1	mm					194:195	> 6 mm	190:195	> 6 mm	190:195	Large (> 6 mm) artificial blood vessels have been successfully employed in clinic practice.
31996289	4	67	theme	angle	701:705	arg1	measurement					707:717	contact angle measurement	693:717	contact angle measurement	693:717	The characteristics of PLLA/PVP films were investigated by scanning electron microscopy (SEM), contact angle measurement and mechanical property testing.
31996289	5	68	theme	fiber	806:810	arg1	films					812:816	the fiber films	802:816	the fiber films	802:816	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	0	69	theme	Small-Diameter	142:155	arg1	Vessels					174:180	Small-Diameter Artificial Blood Vessels	142:180	Small-Diameter Artificial Blood Vessels	142:180	Electrostatic Self-Assemble Modified Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer and Its Potential Applications in Small-Diameter Artificial Blood Vessels.
31996289	5	70	theme	confocal	987:994	arg1	microscopy					996:1005	laser scanning confocal microscopy	972:1005	laser scanning confocal microscopy (LSCM)	972:1012	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	5	70	theme	confocal	987:994	arg1	LSCM					1008:1011	LSCM	1008:1011	LSCM	1008:1011	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	0	71	from	Polymer	100:106	arg1	Vessels					174:180	Small-Diameter Artificial Blood Vessels	142:180	Small-Diameter Artificial Blood Vessels	142:180	Electrostatic Self-Assemble Modified Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer and Its Potential Applications in Small-Diameter Artificial Blood Vessels.
31996289	0	72	theme	Blood	168:172	arg1	Vessels					174:180	Small-Diameter Artificial Blood Vessels	142:180	Small-Diameter Artificial Blood Vessels	142:180	Electrostatic Self-Assemble Modified Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer and Its Potential Applications in Small-Diameter Artificial Blood Vessels.
31996289	5	73	theme	blood	779:783	arg1	compatibility					785:797	blood compatibility	779:797	blood compatibility	779:797	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	5	74	theme	vascular	847:854	arg1	VSMCs					877:881	VSMCs	877:881	VSMCs	877:881	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	5	74	theme	vascular	847:854	arg1	cells					870:874	vascular smooth muscle cells	847:874	vascular smooth muscle cells (VSMCs) proliferation	847:896	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	3	75	theme	poly-L-lactic	439:451	arg1	acid					453:456	poly-L-lactic acid	439:456	poly-L-lactic acid (PLLA)	439:463	In this study, poly-vinylpyrrolidone (PVP) was introduced into poly-L-lactic acid (PLLA) to prepare biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA).
31996289	3	75	theme	poly-L-lactic	439:451	arg1	PLLA					459:462	PLLA	459:462	PLLA	459:462	In this study, poly-vinylpyrrolidone (PVP) was introduced into poly-L-lactic acid (PLLA) to prepare biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA).
31996289	0	76	theme	Electrospun	37:47	arg1	Polymer					100:106	Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer	37:106	Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer	37:106	Electrostatic Self-Assemble Modified Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer and Its Potential Applications in Small-Diameter Artificial Blood Vessels.
31996289	5	77	theme	laser	972:976	arg1	microscopy					996:1005	laser scanning confocal microscopy	972:1005	laser scanning confocal microscopy (LSCM)	972:1012	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	5	77	theme	laser	972:976	arg1	LSCM					1008:1011	LSCM	1008:1011	LSCM	1008:1011	The cytocompatiblility and blood compatibility of the fiber films were further studied through vascular smooth muscle cells (VSMCs) proliferation and platelet adhesion, and the morphology of cells on films was viewed by laser scanning confocal microscopy (LSCM) and SEM.
31996289	7	78	theme	testing	1314:1320	arg1	solutions					1322:1330	the testing solutions	1310:1330	the testing solutions	1310:1330	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	11	79	theme	tissue	1742:1747	arg1	compatibility					1749:1761	good tissue compatibility	1737:1761	good tissue compatibility	1737:1761	The data indicated these films were biodegradable with good tissue compatibility.
31996289	0	80	theme	Acid/Poly-Vinylpyrrolidone	63:88	arg1	Polymer					100:106	Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer	37:106	Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer	37:106	Electrostatic Self-Assemble Modified Electrospun Poly-L-Lactic Acid/Poly-Vinylpyrrolidone Composite Polymer and Its Potential Applications in Small-Diameter Artificial Blood Vessels.
31996289	6	81	theme	ESA-modified	1044:1055	arg1	films					1075:1079	ESA-modified electrospun fiber films	1044:1079	ESA-modified electrospun fiber films	1044:1079	Next, the surface of ESA-modified electrospun fiber films was analyzed through SEM and photoelectron spectroscopy (XPS).
31996289	7	82	theme	SEM	1217:1219	arg1	observation					1221:1231	SEM observation	1217:1231	SEM observation	1217:1231	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	7	83	theme	pH	1297:1298	arg1	change					1300:1305	pH change	1297:1305	pH change in the testing solutions	1297:1330	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
31996289	3	84	theme	blood	517:521	arg1	vessels					523:529	biodegradable small-diameter electrospun blood vessels	476:529	biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA)	476:595	In this study, poly-vinylpyrrolidone (PVP) was introduced into poly-L-lactic acid (PLLA) to prepare biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA).
31996289	10	85	contain	had	1645:1647	arg2	compatibilities					1665:1679	excellent blood compatibilities	1649:1679	excellent blood compatibilities	1649:1679	The films assembled with chitosan/heparin by ESA were beneficial to VSMCs survival and had excellent blood compatibilities.
31996289	10	85	contain	had	1645:1647	arg1	survival					1632:1639	beneficial to VSMCs survival	1612:1639	beneficial to VSMCs survival	1612:1639	The films assembled with chitosan/heparin by ESA were beneficial to VSMCs survival and had excellent blood compatibilities.
31996289	10	85	contain	had	1645:1647	arg1	films					1562:1566	The films	1558:1566	The films assembled with chitosan/heparin by ESA	1558:1605	The films assembled with chitosan/heparin by ESA were beneficial to VSMCs survival and had excellent blood compatibilities.
31996289	3	86	theme	small-diameter	490:503	arg1	vessels					523:529	biodegradable small-diameter electrospun blood vessels	476:529	biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA)	476:595	In this study, poly-vinylpyrrolidone (PVP) was introduced into poly-L-lactic acid (PLLA) to prepare biodegradable small-diameter electrospun blood vessels which were further modified via electrostatic self-assembly (ESA).
31996289	7	87	theme	weight	1275:1280	arg1	reduction					1282:1290	viscosity average molecular weight reduction	1247:1290	viscosity average molecular weight reduction	1247:1290	The degradation characteristics of these films were investigated through SEM observation, weight loss, viscosity average molecular weight reduction, and pH change in the testing solutions as well.
34942215	8	0	theme	carboxyl/hydroxyl	1703:1719	arg1	groups					1721:1726	carboxyl/hydroxyl groups	1703:1726	carboxyl/hydroxyl groups	1703:1726	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	2	1	link	manganese-crosslinked	349:369	arg1	alginate					378:385	a new carbonized manganese-crosslinked sodium alginate	332:385	a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C)	332:395	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	2	1	link	manganese-crosslinked	349:369	arg1	Mn/SA-C					388:394	Mn/SA-C	388:394	Mn/SA-C	388:394	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	2	2	theme	sodium	371:376	arg1	alginate					378:385	a new carbonized manganese-crosslinked sodium alginate	332:385	a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C)	332:395	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	2	2	theme	sodium	371:376	arg1	Mn/SA-C					388:394	Mn/SA-C	388:394	Mn/SA-C	388:394	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	3	3	with	adsorption	611:620	arg1	efficiency					664:673	the removal efficiency	652:673	the removal efficiency of >98%	652:681	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	1	4	theme	toxic	261:265	arg1	oxoanions					267:275	toxic oxoanions	261:275	toxic oxoanions	261:275	The preparation of easily synthesized and cheap composite materials for the efficient removal of toxic oxoanions still remains challenging in sewage treatment.
34942215	8	5	with	Cr	1739:1740	arg1	MnO					1695:1697	MnO	1695:1697	MnO	1695:1697	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	7	6	theme	valence	1585:1591	arg1	cycle					1593:1597	Mn valence cycle	1582:1597	Mn valence cycle	1582:1597	The adsorption removal of arsenic (As) was primarily ascribed to surface complexation with MnO and precipitation by MnS2, and oxidative adsorption because of Mn valence cycle.
34942215	4	7	theme	As	894:895	arg1	efficiency					880:889	The removal efficiency	868:889	The removal efficiency of As(III), As(V), and Cr(VI)	868:919	The removal efficiency of As(III), As(V), and Cr(VI) could be further significantly enhanced by coupling a photocatalytic process.
34942215	8	8	dep	contained	1640:1648	arg1	VI					1629:1630	VI	1629:1630	VI	1629:1630	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	3	9	theme	104.50 mg/g	813:823	arg1	value					784:788	the maximum value	772:788	the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively	772:865	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	4	10	dep	Cr	914:915	arg1	VI					917:918	VI	917:918	VI	917:918	The removal efficiency of As(III), As(V), and Cr(VI) could be further significantly enhanced by coupling a photocatalytic process.
34942215	1	11	theme	synthesized	190:200	arg1	materials					222:230	easily synthesized and cheap composite materials	183:230	easily synthesized and cheap composite materials	183:230	The preparation of easily synthesized and cheap composite materials for the efficient removal of toxic oxoanions still remains challenging in sewage treatment.
34942215	0	12	theme	carbonized	101:110	arg1	alginate					154:161	manganese-crosslinked sodium alginate	125:161	manganese-crosslinked sodium alginate	125:161	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	0	12	theme	carbonized	101:110	arg1	composite					112:120	the carbonized composite	97:120	the carbonized composite of manganese-crosslinked sodium alginate	97:161	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	8	13	with	complexation	1677:1688	arg1	MnO					1695:1697	MnO	1695:1697	MnO	1695:1697	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	1	14	theme	cheap	206:210	arg1	materials					222:230	easily synthesized and cheap composite materials	183:230	easily synthesized and cheap composite materials	183:230	The preparation of easily synthesized and cheap composite materials for the efficient removal of toxic oxoanions still remains challenging in sewage treatment.
34942215	3	15	with	Cr	760:761	arg1	value					784:788	the maximum value	772:788	the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively	772:865	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	9	16	from	removal	1839:1845	arg1	water					1893:1897	contaminated water	1880:1897	contaminated water through an adsorption-photocatalysis synergistic strategy	1880:1955	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	1	17	theme	materials	222:230	arg1	preparation					168:178	The preparation	164:178	The preparation of easily synthesized and cheap composite materials for the efficient removal of toxic oxoanions	164:275	The preparation of easily synthesized and cheap composite materials for the efficient removal of toxic oxoanions still remains challenging in sewage treatment.
34942215	6	18	dep	Cr	1329:1330	arg1	reduction					1336:1344	reduction	1336:1344	reduction	1336:1344	This was primarily attributed to the Mn-catalyzed production of the photocatalytic excitons for Cr(VI) reduction, and the superoxide (•O2-) and hydroxyl (•OH) radicals for As(III) oxidation.
34942215	6	18	dep	Cr	1329:1330	arg1	VI					1332:1333	VI	1332:1333	VI	1332:1333	This was primarily attributed to the Mn-catalyzed production of the photocatalytic excitons for Cr(VI) reduction, and the superoxide (•O2-) and hydroxyl (•OH) radicals for As(III) oxidation.
34942215	9	19	theme	Cr	1870:1871	arg1	removal					1839:1845	rapid and efficient removal	1819:1845	rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy	1819:1955	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	0	20	theme	sodium	147:152	arg1	alginate					154:161	manganese-crosslinked sodium alginate	125:161	manganese-crosslinked sodium alginate	125:161	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	3	21	theme	high	708:711	arg1	capacity					724:731	a high adsorption capacity	706:731	a high adsorption capacity	706:731	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	6	22	theme	excitons	1316:1323	arg1	production					1283:1292	the Mn-catalyzed production	1266:1292	the Mn-catalyzed production of the photocatalytic excitons for Cr(VI) reduction, and the superoxide (•O2-) and hydroxyl (•OH) radicals for As(III) oxidation	1266:1421	This was primarily attributed to the Mn-catalyzed production of the photocatalytic excitons for Cr(VI) reduction, and the superoxide (•O2-) and hydroxyl (•OH) radicals for As(III) oxidation.
34942215	7	23	with	complexation	1497:1508	arg1	precipitation					1523:1535	precipitation	1523:1535	precipitation	1523:1535	The adsorption removal of arsenic (As) was primarily ascribed to surface complexation with MnO and precipitation by MnS2, and oxidative adsorption because of Mn valence cycle.
34942215	7	23	with	complexation	1497:1508	arg1	MnO					1515:1517	MnO	1515:1517	MnO	1515:1517	The adsorption removal of arsenic (As) was primarily ascribed to surface complexation with MnO and precipitation by MnS2, and oxidative adsorption because of Mn valence cycle.
34942215	9	24	theme	synergistic	1936:1946	arg1	strategy					1948:1955	an adsorption-photocatalysis synergistic strategy	1907:1955	an adsorption-photocatalysis synergistic strategy	1907:1955	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	0	25	theme	hexavalent	65:74	arg1	chromium					76:83	hexavalent chromium	65:83	hexavalent chromium	65:83	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	3	26	theme	Langmuir	838:845	arg1	model					847:851	the Langmuir model	834:851	the Langmuir model	834:851	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	2	27	theme	hexavalent	472:481	arg1	chromium					483:490	hexavalent chromium	472:490	hexavalent chromium (Cr(VI))	472:499	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	0	28	from	Adsorption	0:9	arg1	water					88:92	water	88:92	water	88:92	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	8	29	contain	contained	1640:1648	arg2	reduction					1650:1658	reduction	1650:1658	reduction by MnO and MnS2	1650:1674	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	8	29	contain	contained	1640:1648	arg2	complexation					1677:1688	complexation	1677:1688	complexation with MnO	1677:1697	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	8	29	contain	contained	1640:1648	arg2	groups					1721:1726	carboxyl/hydroxyl groups	1703:1726	carboxyl/hydroxyl groups	1703:1726	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	8	29	contain	contained	1640:1648	arg1	mechanisms					1612:1621	The removal mechanisms	1600:1621	The removal mechanisms of Cr	1600:1627	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	8	29	contain	contained	1640:1648	arg2	Cr					1739:1740	Cr	1739:1740	Cr(OH)	1739:1744	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	8	29	contain	contained	1640:1648	arg2	OH					1742:1743	OH	1742:1743	OH	1742:1743	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	6	30	theme	Mn-catalyzed	1270:1281	arg1	production					1283:1292	the Mn-catalyzed production	1266:1292	the Mn-catalyzed production of the photocatalytic excitons for Cr(VI) reduction, and the superoxide (•O2-) and hydroxyl (•OH) radicals for As(III) oxidation	1266:1421	This was primarily attributed to the Mn-catalyzed production of the photocatalytic excitons for Cr(VI) reduction, and the superoxide (•O2-) and hydroxyl (•OH) radicals for As(III) oxidation.
34942215	0	31	link	manganese-crosslinked	125:145	arg1	alginate					154:161	manganese-crosslinked sodium alginate	125:161	manganese-crosslinked sodium alginate	125:161	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	9	32	theme	Mn/SA-C-S	1796:1804	arg1	material					1806:1813	a promising Mn/SA-C-S material	1784:1813	a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy	1784:1955	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	8	33	with	reduction	1650:1658	arg1	MnO					1695:1697	MnO	1695:1697	MnO	1695:1697	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	7	34	theme	surface	1489:1495	arg1	complexation					1497:1508	surface complexation	1489:1508	surface complexation with MnO and precipitation by MnS2, and oxidative adsorption because of Mn valence cycle	1489:1597	The adsorption removal of arsenic (As) was primarily ascribed to surface complexation with MnO and precipitation by MnS2, and oxidative adsorption because of Mn valence cycle.
34942215	2	35	theme	arsenite	431:438	arg1	removal					420:426	the removal	416:426	the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI))	416:499	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	0	36	theme	photocatalysis	15:28	arg1	removal					30:36	photocatalysis removal	15:36	photocatalysis removal	15:36	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	5	37	dep	Cr	1038:1039	arg1	VI					1041:1042	VI	1041:1042	VI	1041:1042	For example, the time in which >98% of Cr(VI) (10 mg/L) was removed dramatically shortened from 360 min (adsorption) to 45 min (adsorption-photocatalysis), and the removal efficiency of As(III) increased by ∼10% within initial 5 min.
34942215	2	38	theme	arsenate	451:458	arg1	removal					420:426	the removal	416:426	the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI))	416:499	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	8	39	theme	removal	1604:1610	arg1	mechanisms					1612:1621	The removal mechanisms	1600:1621	The removal mechanisms of Cr	1600:1627	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	7	40	theme	adsorption	1428:1437	arg1	removal					1439:1445	The adsorption removal	1424:1445	The adsorption removal of arsenic (As)	1424:1461	The adsorption removal of arsenic (As) was primarily ascribed to surface complexation with MnO and precipitation by MnS2, and oxidative adsorption because of Mn valence cycle.
34942215	7	41	theme	cycle	1593:1597	arg1	precipitation					1523:1535	precipitation	1523:1535	precipitation	1523:1535	The adsorption removal of arsenic (As) was primarily ascribed to surface complexation with MnO and precipitation by MnS2, and oxidative adsorption because of Mn valence cycle.
34942215	7	41	theme	cycle	1593:1597	arg1	MnO					1515:1517	MnO	1515:1517	MnO	1515:1517	The adsorption removal of arsenic (As) was primarily ascribed to surface complexation with MnO and precipitation by MnS2, and oxidative adsorption because of Mn valence cycle.
34942215	5	42	theme	removal	1163:1169	arg1	efficiency					1171:1180	the removal efficiency	1159:1180	the removal efficiency of As(III)	1159:1191	For example, the time in which >98% of Cr(VI) (10 mg/L) was removed dramatically shortened from 360 min (adsorption) to 45 min (adsorption-photocatalysis), and the removal efficiency of As(III) increased by ∼10% within initial 5 min.
34942215	2	43	dep	arsenite	431:438	arg1	As					441:442	As	441:442	As	441:442	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	2	44	theme	manganese-crosslinked	349:369	arg1	alginate					378:385	a new carbonized manganese-crosslinked sodium alginate	332:385	a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C)	332:395	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	2	44	theme	manganese-crosslinked	349:369	arg1	Mn/SA-C					388:394	Mn/SA-C	388:394	Mn/SA-C	388:394	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	9	45	dep	Cr	1870:1871	arg1	VI					1873:1874	VI	1873:1874	VI	1873:1874	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	2	46	theme	new	334:336	arg1	alginate					378:385	a new carbonized manganese-crosslinked sodium alginate	332:385	a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C)	332:395	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	2	46	theme	new	334:336	arg1	Mn/SA-C					388:394	Mn/SA-C	388:394	Mn/SA-C	388:394	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	7	47	theme	arsenic	1450:1456	arg1	removal					1439:1445	The adsorption removal	1424:1445	The adsorption removal of arsenic (As)	1424:1461	The adsorption removal of arsenic (As) was primarily ascribed to surface complexation with MnO and precipitation by MnS2, and oxidative adsorption because of Mn valence cycle.
34942215	5	48	theme	initial	1218:1224	arg1	5 min					1226:1230	initial 5 min	1218:1230	initial 5 min	1218:1230	For example, the time in which >98% of Cr(VI) (10 mg/L) was removed dramatically shortened from 360 min (adsorption) to 45 min (adsorption-photocatalysis), and the removal efficiency of As(III) increased by ∼10% within initial 5 min.
34942215	1	49	theme	efficient	240:248	arg1	removal					250:256	the efficient removal	236:256	the efficient removal of toxic oxoanions	236:275	The preparation of easily synthesized and cheap composite materials for the efficient removal of toxic oxoanions still remains challenging in sewage treatment.
34942215	0	50	theme	arsenate	51:58	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption	0:9	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	0	50	theme	arsenate	51:58	arg1	removal					30:36	photocatalysis removal	15:36	photocatalysis removal	15:36	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	6	51	dep	oxidation	1413:1421	arg1	III					1408:1410	III	1408:1410	III	1408:1410	This was primarily attributed to the Mn-catalyzed production of the photocatalytic excitons for Cr(VI) reduction, and the superoxide (•O2-) and hydroxyl (•OH) radicals for As(III) oxidation.
34942215	3	52	theme	189.29	793:798	arg1	value					784:788	the maximum value	772:788	the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively	772:865	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	3	53	theme	rapid	605:609	arg1	adsorption					611:620	a rapid adsorption	603:620	a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98%	603:681	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	1	54	theme	oxoanions	267:275	arg1	removal					250:256	the efficient removal	236:256	the efficient removal of toxic oxoanions	236:275	The preparation of easily synthesized and cheap composite materials for the efficient removal of toxic oxoanions still remains challenging in sewage treatment.
34942215	2	55	dep	chromium	483:490	arg1	Cr					493:494	Cr	493:494	Cr	493:494	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	9	56	theme	As	1850:1851	arg1	removal					1839:1845	rapid and efficient removal	1819:1845	rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy	1819:1955	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	8	57	dep	reduction	1650:1658	arg1	precipitation					1747:1759	3 precipitation	1745:1759	3 precipitation	1745:1759	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	3	58	dep	Cr	760:761	arg1	VI					763:764	VI	763:764	VI	763:764	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	2	59	dep	Cr	493:494	arg1	VI					496:497	VI	496:497	VI	496:497	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	3	60	contain	had	702:704	arg2	capacity					724:731	a high adsorption capacity	706:731	a high adsorption capacity	706:731	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	3	60	contain	had	702:704	arg1	Mn/SA-C					542:548	the Mn/SA-C	538:548	the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S)	538:591	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	7	61	theme	Mn	1582:1583	arg1	cycle					1593:1597	Mn valence cycle	1582:1597	Mn valence cycle	1582:1597	The adsorption removal of arsenic (As) was primarily ascribed to surface complexation with MnO and precipitation by MnS2, and oxidative adsorption because of Mn valence cycle.
34942215	9	62	attach	removal	1839:1845	arg2	As					1850:1851	As	1850:1851	As	1850:1851	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	9	62	attach	removal	1839:1845	arg2	III					1853:1855	III	1853:1855	III	1853:1855	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	9	62	attach	removal	1839:1845	arg2	As					1859:1860	As	1859:1860	As	1859:1860	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	9	62	attach	removal	1839:1845	arg2	Cr					1870:1871	Cr	1870:1871	Cr(VI)	1870:1875	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	9	62	attach	removal	1839:1845	arg2	V					1862:1862	V	1862:1862	V	1862:1862	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	9	62	attach	removal	1839:1845	arg3	water					1893:1897	contaminated water	1880:1897	contaminated water through an adsorption-photocatalysis synergistic strategy	1880:1955	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	3	63	theme	193.29	801:806	arg1	value					784:788	the maximum value	772:788	the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively	772:865	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	4	64	theme	removal	872:878	arg1	efficiency					880:889	The removal efficiency	868:889	The removal efficiency of As(III), As(V), and Cr(VI)	868:919	The removal efficiency of As(III), As(V), and Cr(VI) could be further significantly enhanced by coupling a photocatalytic process.
34942215	0	65	from	chromium	76:83	arg1	water					88:92	water	88:92	water	88:92	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	0	66	theme	manganese-crosslinked	125:145	arg1	alginate					154:161	manganese-crosslinked sodium alginate	125:161	manganese-crosslinked sodium alginate	125:161	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	9	67	theme	contaminated	1880:1891	arg1	water					1893:1897	contaminated water	1880:1897	contaminated water through an adsorption-photocatalysis synergistic strategy	1880:1955	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	1	68	theme	composite	212:220	arg1	materials					222:230	easily synthesized and cheap composite materials	183:230	easily synthesized and cheap composite materials	183:230	The preparation of easily synthesized and cheap composite materials for the efficient removal of toxic oxoanions still remains challenging in sewage treatment.
34942215	7	69	theme	oxidative	1550:1558	arg1	adsorption					1560:1569	oxidative adsorption	1550:1569	oxidative adsorption	1550:1569	The adsorption removal of arsenic (As) was primarily ascribed to surface complexation with MnO and precipitation by MnS2, and oxidative adsorption because of Mn valence cycle.
34942215	2	70	theme	chromium	483:490	arg1	removal					420:426	the removal	416:426	the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI))	416:499	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	3	71	theme	removal	656:662	arg1	efficiency					664:673	the removal efficiency	652:673	the removal efficiency of >98%	652:681	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	0	72	theme	alginate	154:161	arg1	alginate					154:161	manganese-crosslinked sodium alginate	125:161	manganese-crosslinked sodium alginate	125:161	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	0	72	theme	alginate	154:161	arg1	composite					112:120	the carbonized composite	97:120	the carbonized composite of manganese-crosslinked sodium alginate	97:161	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	4	73	theme	Cr	914:915	arg1	efficiency					880:889	The removal efficiency	868:889	The removal efficiency of As(III), As(V), and Cr(VI)	868:919	The removal efficiency of As(III), As(V), and Cr(VI) could be further significantly enhanced by coupling a photocatalytic process.
34942215	9	74	theme	adsorption-photocatalysis	1910:1934	arg1	strategy					1948:1955	an adsorption-photocatalysis synergistic strategy	1907:1955	an adsorption-photocatalysis synergistic strategy	1907:1955	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	3	75	theme	adsorption	713:722	arg1	capacity					724:731	a high adsorption capacity	706:731	a high adsorption capacity	706:731	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	6	76	theme	photocatalytic	1301:1314	arg1	excitons					1316:1323	the photocatalytic excitons	1297:1323	the photocatalytic excitons for Cr(VI) reduction, and the superoxide (•O2-) and hydroxyl (•OH) radicals for As(III) oxidation	1297:1421	This was primarily attributed to the Mn-catalyzed production of the photocatalytic excitons for Cr(VI) reduction, and the superoxide (•O2-) and hydroxyl (•OH) radicals for As(III) oxidation.
34942215	4	77	theme	As	903:904	arg1	efficiency					880:889	The removal efficiency	868:889	The removal efficiency of As(III), As(V), and Cr(VI)	868:919	The removal efficiency of As(III), As(V), and Cr(VI) could be further significantly enhanced by coupling a photocatalytic process.
34942215	3	78	theme	%	681:681	arg1	efficiency					664:673	the removal efficiency	652:673	the removal efficiency of >98%	652:681	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	0	79	from	water	88:92	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption	0:9	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	0	79	from	water	88:92	arg1	removal					30:36	photocatalysis removal	15:36	photocatalysis removal	15:36	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	0	80	from	removal	30:36	arg1	water					88:92	water	88:92	water	88:92	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	0	81	theme	chromium	76:83	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption	0:9	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	0	81	theme	chromium	76:83	arg1	removal					30:36	photocatalysis removal	15:36	photocatalysis removal	15:36	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	2	82	dep	arsenate	451:458	arg1	As					461:462	As	461:462	As	461:462	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	7	83	dep	arsenic	1450:1456	arg1	As					1459:1460	As	1459:1460	As	1459:1460	The adsorption removal of arsenic (As) was primarily ascribed to surface complexation with MnO and precipitation by MnS2, and oxidative adsorption because of Mn valence cycle.
34942215	0	84	from	arsenate	51:58	arg1	water					88:92	water	88:92	water	88:92	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	9	85	theme	promising	1786:1794	arg1	material					1806:1813	a promising Mn/SA-C-S material	1784:1813	a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy	1784:1955	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	2	86	dep	As	441:442	arg1	III					444:446	III	444:446	III	444:446	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	0	87	from	arsenite	41:48	arg1	water					88:92	water	88:92	water	88:92	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	6	88	theme	As	1405:1406	arg1	oxidation					1413:1421	As(III) oxidation	1405:1421	As(III) oxidation	1405:1421	This was primarily attributed to the Mn-catalyzed production of the photocatalytic excitons for Cr(VI) reduction, and the superoxide (•O2-) and hydroxyl (•OH) radicals for As(III) oxidation.
34942215	9	89	theme	rapid	1819:1823	arg1	removal					1839:1845	rapid and efficient removal	1819:1845	rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy	1819:1955	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	5	90	theme	III	1188:1190	arg1	efficiency					1171:1180	the removal efficiency	1159:1180	the removal efficiency of As(III)	1159:1191	For example, the time in which >98% of Cr(VI) (10 mg/L) was removed dramatically shortened from 360 min (adsorption) to 45 min (adsorption-photocatalysis), and the removal efficiency of As(III) increased by ∼10% within initial 5 min.
34942215	3	91	theme	MnSO4	566:570	arg1	Mn/SA-C-S					582:590	Mn/SA-C-S	582:590	Mn/SA-C-S	582:590	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	3	91	theme	MnSO4	566:570	arg1	solution					572:579	MnSO4 solution	566:579	MnSO4 solution (Mn/SA-C-S)	566:591	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	9	92	theme	efficient	1829:1837	arg1	removal					1839:1845	rapid and efficient removal	1819:1845	rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy	1819:1955	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	0	93	theme	arsenite	41:48	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption	0:9	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	0	93	theme	arsenite	41:48	arg1	removal					30:36	photocatalysis removal	15:36	photocatalysis removal	15:36	Adsorption and photocatalysis removal of arsenite, arsenate, and hexavalent chromium in water by the carbonized composite of manganese-crosslinked sodium alginate.
34942215	1	94	theme	sewage	306:311	arg1	treatment					313:321	sewage treatment	306:321	sewage treatment	306:321	The preparation of easily synthesized and cheap composite materials for the efficient removal of toxic oxoanions still remains challenging in sewage treatment.
34942215	8	95	theme	Cr	1626:1627	arg1	mechanisms					1612:1621	The removal mechanisms	1600:1621	The removal mechanisms of Cr	1600:1627	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
34942215	2	96	dep	As	461:462	arg1	V					464:464	V	464:464	V	464:464	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	6	97	theme	hydroxyl	1377:1384	arg1	radicals					1392:1399	the superoxide (•O2-) and hydroxyl (•OH) radicals	1351:1399	radicals	1392:1399	This was primarily attributed to the Mn-catalyzed production of the photocatalytic excitons for Cr(VI) reduction, and the superoxide (•O2-) and hydroxyl (•OH) radicals for As(III) oxidation.
34942215	6	97	theme	hydroxyl	1377:1384	arg1	•OH					1387:1389	•OH	1387:1389	•OH	1387:1389	This was primarily attributed to the Mn-catalyzed production of the photocatalytic excitons for Cr(VI) reduction, and the superoxide (•O2-) and hydroxyl (•OH) radicals for As(III) oxidation.
34942215	2	98	theme	carbonized	338:347	arg1	alginate					378:385	a new carbonized manganese-crosslinked sodium alginate	332:385	a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C)	332:395	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	2	98	theme	carbonized	338:347	arg1	Mn/SA-C					388:394	Mn/SA-C	388:394	Mn/SA-C	388:394	Herein, a new carbonized manganese-crosslinked sodium alginate (Mn/SA-C) was fabricated for the removal of arsenite (As(III)), arsenate (As(V)) and hexavalent chromium (Cr(VI)) in water.
34942215	4	99	theme	photocatalytic	975:988	arg1	process					990:996	a photocatalytic process	973:996	a photocatalytic process	973:996	The removal efficiency of As(III), As(V), and Cr(VI) could be further significantly enhanced by coupling a photocatalytic process.
34942215	5	100	theme	Cr	1038:1039	arg1	10 mg/L					1046:1052	10 mg/L	1046:1052	10 mg/L	1046:1052	For example, the time in which >98% of Cr(VI) (10 mg/L) was removed dramatically shortened from 360 min (adsorption) to 45 min (adsorption-photocatalysis), and the removal efficiency of As(III) increased by ∼10% within initial 5 min.
34942215	5	100	theme	Cr	1038:1039	arg1	Cr					1038:1039	Cr	1038:1039	Cr(VI) (10 mg/L)	1038:1053	For example, the time in which >98% of Cr(VI) (10 mg/L) was removed dramatically shortened from 360 min (adsorption) to 45 min (adsorption-photocatalysis), and the removal efficiency of As(III) increased by ∼10% within initial 5 min.
34942215	5	100	theme	Cr	1038:1039	arg1	%					1033:1033	>98%	1030:1033	>98% of Cr(VI) (10 mg/L)	1030:1053	For example, the time in which >98% of Cr(VI) (10 mg/L) was removed dramatically shortened from 360 min (adsorption) to 45 min (adsorption-photocatalysis), and the removal efficiency of As(III) increased by ∼10% within initial 5 min.
34942215	3	101	theme	maximum	776:782	arg1	value					784:788	the maximum value	772:788	the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively	772:865	The results indicated that the Mn/SA-C pretreated with MnSO4 solution (Mn/SA-C-S) exhibited a rapid adsorption toward As(III) and As(V) with the removal efficiency of >98% within 10 min, and had a high adsorption capacity toward As(III), As(V), and Cr(VI) with the maximum value of 189.29, 193.29, and 104.50 mg/g based on the Langmuir model, respectively.
34942215	9	102	theme	As	1859:1860	arg1	removal					1839:1845	rapid and efficient removal	1819:1845	rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy	1819:1955	Our research provides a promising Mn/SA-C-S material for rapid and efficient removal of As(III), As(V), and Cr(VI) in contaminated water through an adsorption-photocatalysis synergistic strategy.
34942215	8	103	with	groups	1721:1726	arg1	MnO					1695:1697	MnO	1695:1697	MnO	1695:1697	The removal mechanisms of Cr(VI) mainly contained reduction by MnO and MnS2, complexation with MnO and carboxyl/hydroxyl groups as well as Cr(OH)3 precipitation.
33945881	10	0	theme	wrinkling	2495:2503	arg1	processes					2505:2513	the electrospinning and thermal wrinkling processes	2463:2513	the electrospinning and thermal wrinkling processes respectively	2463:2526	Fiber orientation/density and wrinkle geometry can be independently controlled during the electrospinning and thermal wrinkling processes respectively, demonstrating the flexibility of this technique for creating well-defined multiscale hydrogel structures.
33945881	10	1	theme	well-defined	2590:2601	arg1	structures					2623:2632	well-defined multiscale hydrogel structures	2590:2632	well-defined multiscale hydrogel structures	2590:2632	Fiber orientation/density and wrinkle geometry can be independently controlled during the electrospinning and thermal wrinkling processes respectively, demonstrating the flexibility of this technique for creating well-defined multiscale hydrogel structures.
33945881	8	2	theme	secondary	1976:1984	arg1	morphologies					1986:1997	secondary morphologies	1976:1997	secondary morphologies within individual hydrogels	1976:2025	Furthermore, the incorporation of secondary morphologies within individual hydrogels via simple manufacturing techniques would represent a significant advancement in the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions.
33945881	1	3	theme	controlling	278:288	arg1	morphology					294:303	the morphology	290:303	controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues	278:396	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	2	4	theme	wrinkled	660:667	arg1	micro					670:674	a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	631:705	micro	670:674	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	8	5	from	advancement	2093:2103	arg1	field					2112:2116	the field	2108:2116	the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions	2108:2209	Furthermore, the incorporation of secondary morphologies within individual hydrogels via simple manufacturing techniques would represent a significant advancement in the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions.
33945881	9	6	theme	structured	2309:2318	arg1	hydrogels					2320:2328	structured hydrogels	2309:2328	structured hydrogels with microscale wrinkles and nanoscale fibers	2309:2374	Herein, we leverage a two-step process based on electrospinning and thermal wrinkling to prepare structured hydrogels with microscale wrinkles and nanoscale fibers.
33945881	5	7	theme	improved	1257:1264	arg1	alignment					1271:1279	improved cell alignment	1257:1279	improved cell alignment along the wrinkle direction	1257:1307	While the nanofiber orientation had a smaller effect on cell alignment, parallel nanofibers promoted improved cell alignment along the wrinkle direction while perpendicular nanofibers disrupted alignment.
33945881	7	8	theme	multiple	1898:1905	arg1	scales					1914:1919	multiple length scales	1898:1919	multiple length scales	1898:1919	STATEMENT OF SIGNIFICANCE: While structured hydrogels can mimic the morphology of natural tissues, controlling this morphology over multiple length scales remains challenging.
33945881	8	9	theme	significant	2081:2091	arg1	advancement					2093:2103	a significant advancement	2079:2103	a significant advancement in the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions	2079:2209	Furthermore, the incorporation of secondary morphologies within individual hydrogels via simple manufacturing techniques would represent a significant advancement in the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions.
33945881	8	10	theme	simple	2031:2036	arg1	techniques					2052:2061	simple manufacturing techniques	2031:2061	simple manufacturing techniques	2031:2061	Furthermore, the incorporation of secondary morphologies within individual hydrogels via simple manufacturing techniques would represent a significant advancement in the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions.
33945881	2	11	theme	nanocrystal	598:608	arg1	sheets					619:624	nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets	534:624	nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	534:705	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	4	12	theme	uniaxially	1128:1137	arg1	sheets					1148:1153	uniaxially wrinkled sheets	1128:1153	uniaxially wrinkled sheets	1128:1153	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	9	13	theme	nanoscale	2359:2367	arg1	fibers					2369:2374	nanoscale fibers	2359:2374	nanoscale fibers	2359:2374	Herein, we leverage a two-step process based on electrospinning and thermal wrinkling to prepare structured hydrogels with microscale wrinkles and nanoscale fibers.
33945881	6	14	theme	2.5D	1621:1624	arg1	"					1625:1625	a "2.5D"	1618:1625	a "2.5D" environment	1618:1637	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	1	15	theme	native	234:239	arg1	environments					246:257	native cell environments	234:257	native cell environments	234:257	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	4	16	theme	C2C12	961:965	arg1	cells					989:993	Adhered C2C12 mouse myoblast muscle cells	953:993	Adhered C2C12 mouse myoblast muscle cells	953:993	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	7	17	theme	natural	1848:1854	arg1	tissues					1856:1862	natural tissues	1848:1862	natural tissues	1848:1862	STATEMENT OF SIGNIFICANCE: While structured hydrogels can mimic the morphology of natural tissues, controlling this morphology over multiple length scales remains challenging.
33945881	3	18	theme	wrinkling	809:817	arg1	process					819:825	the thermal wrinkling process	797:825	the thermal wrinkling process	797:825	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	1	19	theme	environments	246:257	arg1	morphology					220:229	morphology	220:229	morphology	220:229	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	1	19	theme	environments	246:257	arg1	mechanics					206:214	mechanics	206:214	mechanics	206:214	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	2	20	theme	tunable	640:646	arg1	micro					670:674	a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	631:705	micro	670:674	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	5	21	theme	cell	1212:1215	arg1	alignment					1217:1225	cell alignment	1212:1225	cell alignment	1212:1225	While the nanofiber orientation had a smaller effect on cell alignment, parallel nanofibers promoted improved cell alignment along the wrinkle direction while perpendicular nanofibers disrupted alignment.
33945881	6	22	theme	tunable	1372:1378	arg1	structures					1380:1389	The highly tunable structures	1361:1389	The highly tunable structures demonstrated	1361:1402	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	6	22	theme	tunable	1372:1378	arg1	some					1408:1411	some	1408:1411	some	1408:1411	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	6	22	theme	tunable	1372:1378	arg1	morphologies					1433:1444	the most complex morphologies	1416:1444	the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches	1416:1539	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	3	23	dep	density	851:857	arg1	biaxial					899:905	biaxial	899:905	biaxial	899:905	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	3	23	dep	density	851:857	arg1	uniaxial					910:917	uniaxial	910:917	uniaxial	910:917	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	1	24	theme	hydrogel	157:164	arg1	sheets					166:171	Structured hydrogel sheets	146:171	Structured hydrogel sheets	146:171	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	3	25	theme	wrinkle	881:887	arg1	geometry					889:896	wrinkle geometry	881:896	wrinkle geometry	881:896	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	3	26	theme	hydrogel	832:839	arg1	density					851:857	the hydrogel nanofiber density	828:857	the hydrogel nanofiber density	828:857	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	2	27	theme	nanocomposite	534:546	arg1	poly					548:551	nanocomposite poly	534:551	nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	534:705	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	2	27	theme	nanocomposite	534:546	arg1	methacrylate					574:585	oligoethylene glycol methacrylate	553:585	oligoethylene glycol methacrylate	553:585	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	10	28	theme	technique	2567:2575	arg1	flexibility					2547:2557	the flexibility	2543:2557	the flexibility of this technique for creating well-defined multiscale hydrogel structures	2543:2632	Fiber orientation/density and wrinkle geometry can be independently controlled during the electrospinning and thermal wrinkling processes respectively, demonstrating the flexibility of this technique for creating well-defined multiscale hydrogel structures.
33945881	3	29	theme	fiber	860:864	arg1	alignment					866:874	fiber alignment	860:874	fiber alignment	860:874	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	0	30	theme	sequential	96:105	arg1	electrospinning					107:121	sequential electrospinning	96:121	sequential electrospinning	96:121	Multi-scale structuring of cell-instructive cellulose nanocrystal composite hydrogel sheets via sequential electrospinning and thermal wrinkling.
33945881	1	31	theme	consistent	364:373	arg1	cues					393:396	cells consistent multi-dimensional cues	358:396	cells consistent multi-dimensional cues	358:396	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	6	32	theme	tissue	1745:1750	arg1	regeneration					1752:1763	in vivo tissue regeneration	1737:1763	in vivo tissue regeneration	1737:1763	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	10	33	theme	electrospinning	2467:2481	arg1	processes					2505:2513	the electrospinning and thermal wrinkling processes	2463:2513	the electrospinning and thermal wrinkling processes respectively	2463:2526	Fiber orientation/density and wrinkle geometry can be independently controlled during the electrospinning and thermal wrinkling processes respectively, demonstrating the flexibility of this technique for creating well-defined multiscale hydrogel structures.
33945881	4	34	theme	myoblast	973:980	arg1	cells					989:993	Adhered C2C12 mouse myoblast muscle cells	953:993	Adhered C2C12 mouse myoblast muscle cells	953:993	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	11	35	theme	cell	2708:2711	arg1	alignment					2713:2721	cell alignment	2708:2721	cell alignment	2708:2721	Finally, we show that while wrinkle geometry is the major determinant of cell alignment, nanofiber orientation also plays a role in this process.
33945881	5	36	theme	perpendicular	1315:1327	arg1	nanofibers					1329:1338	perpendicular nanofibers	1315:1338	perpendicular nanofibers	1315:1338	While the nanofiber orientation had a smaller effect on cell alignment, parallel nanofibers promoted improved cell alignment along the wrinkle direction while perpendicular nanofibers disrupted alignment.
33945881	6	37	theme	complex	1425:1431	arg1	morphologies					1433:1444	the most complex morphologies	1416:1444	the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches	1416:1539	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	6	38	theme	in	1737:1738	arg1	regeneration					1752:1763	in vivo tissue regeneration	1737:1763	in vivo tissue regeneration	1737:1763	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	2	39	theme	glycol	567:572	arg1	poly					548:551	nanocomposite poly	534:551	nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	534:705	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	2	39	theme	glycol	567:572	arg1	methacrylate					574:585	oligoethylene glycol methacrylate	553:585	oligoethylene glycol methacrylate	553:585	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	2	40	theme	nano	690:693	arg1	morphology					696:705	a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	631:705	morphology	696:705	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	8	41	theme	opportunity	2152:2162	arg1	field					2112:2116	the field	2108:2116	the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions	2108:2209	Furthermore, the incorporation of secondary morphologies within individual hydrogels via simple manufacturing techniques would represent a significant advancement in the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions.
33945881	7	42	theme	SIGNIFICANCE	1779:1790	arg1	STATEMENT					1766:1774	STATEMENT	1766:1774	STATEMENT OF SIGNIFICANCE: While structured hydrogels can mimic the morphology of natural tissues, controlling this morphology over multiple length scales remains challenging.	1766:1940	STATEMENT OF SIGNIFICANCE: While structured hydrogels can mimic the morphology of natural tissues, controlling this morphology over multiple length scales remains challenging.
33945881	10	43	theme	hydrogel	2614:2621	arg1	structures					2623:2632	well-defined multiscale hydrogel structures	2590:2632	well-defined multiscale hydrogel structures	2590:2632	Fiber orientation/density and wrinkle geometry can be independently controlled during the electrospinning and thermal wrinkling processes respectively, demonstrating the flexibility of this technique for creating well-defined multiscale hydrogel structures.
33945881	0	44	theme	Multi-scale	0:10	arg1	structuring					12:22	Multi-scale structuring	0:22	Multi-scale structuring of cell-instructive cellulose	0:52	Multi-scale structuring of cell-instructive cellulose nanocrystal composite hydrogel sheets via sequential electrospinning and thermal wrinkling.
33945881	6	45	dep	in	1737:1738	arg1	vivo					1740:1743	vivo	1740:1743	vivo	1740:1743	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	8	46	theme	cell-biomaterial	2181:2196	arg1	interactions					2198:2209	complex cell-biomaterial interactions	2173:2209	complex cell-biomaterial interactions	2173:2209	Furthermore, the incorporation of secondary morphologies within individual hydrogels via simple manufacturing techniques would represent a significant advancement in the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions.
33945881	1	47	theme	sheets	313:318	arg1	morphology					294:303	the morphology	290:303	controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues	278:396	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	4	48	theme	biaxially	1027:1035	arg1	sheets					1046:1051	biaxially wrinkled sheets	1027:1051	biaxially wrinkled sheets	1027:1051	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	2	49	theme	simple	442:447	arg1	process					458:464	a simple two-step process	440:464	a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	440:705	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	6	50	theme	intensive	1498:1506	arg1	approaches					1530:1539	intensive micro/nanofabrication approaches	1498:1539	intensive micro/nanofabrication approaches	1498:1539	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	1	51	theme	multiple	327:334	arg1	scales					343:348	multiple length scales	327:348	multiple length scales	327:348	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	0	52	theme	cellulose	44:52	arg1	structuring					12:22	Multi-scale structuring	0:22	Multi-scale structuring of cell-instructive cellulose	0:52	Multi-scale structuring of cell-instructive cellulose nanocrystal composite hydrogel sheets via sequential electrospinning and thermal wrinkling.
33945881	2	53	theme	/cellulose	587:596	arg1	sheets					619:624	nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets	534:624	nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	534:705	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	2	54	theme	thermal	506:512	arg1	wrinkling					514:522	thermal wrinkling	506:522	thermal wrinkling	506:522	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	0	55	theme	composite	66:74	arg1	sheets					85:90	composite hydrogel sheets	66:90	composite hydrogel sheets	66:90	Multi-scale structuring of cell-instructive cellulose nanocrystal composite hydrogel sheets via sequential electrospinning and thermal wrinkling.
33945881	5	56	theme	smaller	1194:1200	arg1	effect					1202:1207	a smaller effect	1192:1207	a smaller effect	1192:1207	While the nanofiber orientation had a smaller effect on cell alignment, parallel nanofibers promoted improved cell alignment along the wrinkle direction while perpendicular nanofibers disrupted alignment.
33945881	6	57	dep	regulate	1578:1585	arg1	surface					1647:1653	a surface	1645:1653	a surface	1645:1653	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	10	58	theme	Fiber	2377:2381	arg1	orientation/density					2383:2401	Fiber orientation/density	2377:2401	Fiber orientation/density	2377:2401	Fiber orientation/density and wrinkle geometry can be independently controlled during the electrospinning and thermal wrinkling processes respectively, demonstrating the flexibility of this technique for creating well-defined multiscale hydrogel structures.
33945881	5	59	theme	cell	1266:1269	arg1	alignment					1271:1279	improved cell alignment	1257:1279	improved cell alignment along the wrinkle direction	1257:1307	While the nanofiber orientation had a smaller effect on cell alignment, parallel nanofibers promoted improved cell alignment along the wrinkle direction while perpendicular nanofibers disrupted alignment.
33945881	6	60	theme	cell-substrate	1587:1600	arg1	interactions					1602:1613	cell-substrate interactions	1587:1613	cell-substrate interactions	1587:1613	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	3	61	theme	rotation	748:755	arg1	speed					757:761	rotation speed	748:761	rotation speed of the collector	748:778	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	8	62	theme	morphologies	1986:1997	arg1	incorporation					1959:1971	the incorporation	1955:1971	the incorporation of secondary morphologies within individual hydrogels via simple manufacturing techniques	1955:2061	Furthermore, the incorporation of secondary morphologies within individual hydrogels via simple manufacturing techniques would represent a significant advancement in the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions.
33945881	9	63	theme	microscale	2335:2344	arg1	wrinkles					2346:2353	microscale wrinkles	2335:2353	microscale wrinkles	2335:2353	Herein, we leverage a two-step process based on electrospinning and thermal wrinkling to prepare structured hydrogels with microscale wrinkles and nanoscale fibers.
33945881	5	64	theme	parallel	1228:1235	arg1	nanofibers					1237:1246	parallel nanofibers	1228:1246	parallel nanofibers	1228:1246	While the nanofiber orientation had a smaller effect on cell alignment, parallel nanofibers promoted improved cell alignment along the wrinkle direction while perpendicular nanofibers disrupted alignment.
33945881	10	65	theme	thermal	2487:2493	arg1	processes					2505:2513	the electrospinning and thermal wrinkling processes	2463:2513	the electrospinning and thermal wrinkling processes respectively	2463:2526	Fiber orientation/density and wrinkle geometry can be independently controlled during the electrospinning and thermal wrinkling processes respectively, demonstrating the flexibility of this technique for creating well-defined multiscale hydrogel structures.
33945881	7	66	theme	length	1907:1912	arg1	scales					1914:1919	multiple length scales	1898:1919	multiple length scales	1898:1919	STATEMENT OF SIGNIFICANCE: While structured hydrogels can mimic the morphology of natural tissues, controlling this morphology over multiple length scales remains challenging.
33945881	3	67	theme	electrospinning	731:745	arg1	geometry					785:792	geometry	785:792	geometry of the thermal wrinkling process	785:825	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	3	67	theme	electrospinning	731:745	arg1	speed					757:761	rotation speed	748:761	rotation speed of the collector	748:778	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	3	67	theme	electrospinning	731:745	arg1	time					723:726	the time	719:726	the time of electrospinning	719:745	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	8	68	theme	individual	2006:2015	arg1	hydrogels					2017:2025	individual hydrogels	2006:2025	individual hydrogels	2006:2025	Furthermore, the incorporation of secondary morphologies within individual hydrogels via simple manufacturing techniques would represent a significant advancement in the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions.
33945881	2	69	theme	multi-scale	648:658	arg1	micro					670:674	a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	631:705	micro	670:674	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	3	70	theme	collector	770:778	arg1	geometry					785:792	geometry	785:792	geometry of the thermal wrinkling process	785:825	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	3	70	theme	collector	770:778	arg1	speed					757:761	rotation speed	748:761	rotation speed of the collector	748:778	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	3	70	theme	collector	770:778	arg1	time					723:726	the time	719:726	the time of electrospinning	719:745	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	4	71	dep	morphology	1069:1078	arg1	directed					1081:1088	directed	1081:1088	directed preferentially along the wrinkles	1081:1122	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	10	72	theme	multiscale	2603:2612	arg1	structures					2623:2632	well-defined multiscale hydrogel structures	2590:2632	well-defined multiscale hydrogel structures	2590:2632	Fiber orientation/density and wrinkle geometry can be independently controlled during the electrospinning and thermal wrinkling processes respectively, demonstrating the flexibility of this technique for creating well-defined multiscale hydrogel structures.
33945881	2	73	theme	fibrous	681:687	arg1	morphology					696:705	a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	631:705	morphology	696:705	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	8	74	theme	structured	2121:2130	arg1	biomaterials					2132:2143	structured biomaterials	2121:2143	structured biomaterials	2121:2143	Furthermore, the incorporation of secondary morphologies within individual hydrogels via simple manufacturing techniques would represent a significant advancement in the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions.
33945881	8	75	theme	manufacturing	2038:2050	arg1	techniques					2052:2061	simple manufacturing techniques	2031:2061	simple manufacturing techniques	2031:2061	Furthermore, the incorporation of secondary morphologies within individual hydrogels via simple manufacturing techniques would represent a significant advancement in the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions.
33945881	5	76	theme	nanofiber	1166:1174	arg1	orientation					1176:1186	the nanofiber orientation	1162:1186	the nanofiber orientation	1162:1186	While the nanofiber orientation had a smaller effect on cell alignment, parallel nanofibers promoted improved cell alignment along the wrinkle direction while perpendicular nanofibers disrupted alignment.
33945881	6	77	dep	surface	1647:1653	arg1	i.e.					1640:1643	i.e.	1640:1643	i.e.	1640:1643	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	4	78	theme	wrinkled	1139:1146	arg1	sheets					1148:1153	uniaxially wrinkled sheets	1128:1153	uniaxially wrinkled sheets	1128:1153	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	10	79	theme	wrinkle	2407:2413	arg1	geometry					2415:2422	wrinkle geometry	2407:2422	wrinkle geometry	2407:2422	Fiber orientation/density and wrinkle geometry can be independently controlled during the electrospinning and thermal wrinkling processes respectively, demonstrating the flexibility of this technique for creating well-defined multiscale hydrogel structures.
33945881	6	80	theme	"	1625:1625	arg1	environment					1627:1637	a "2.5D" environment	1618:1637	a "2.5D" environment	1618:1637	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	2	81	theme	hydrogel	610:617	arg1	sheets					619:624	nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets	534:624	nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	534:705	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	6	82	with	surface	1647:1653	arg1	topographies					1692:1703	both micro- and nano-structured topographies	1660:1703	both micro- and nano-structured topographies	1660:1703	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	1	83	theme	cell	241:244	arg1	environments					246:257	native cell environments	234:257	native cell environments	234:257	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	4	84	theme	Adhered	953:959	arg1	cells					989:993	Adhered C2C12 mouse myoblast muscle cells	953:993	Adhered C2C12 mouse myoblast muscle cells	953:993	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	11	85	theme	wrinkle	2663:2669	arg1	geometry					2671:2678	wrinkle geometry	2663:2678	wrinkle geometry	2663:2678	Finally, we show that while wrinkle geometry is the major determinant of cell alignment, nanofiber orientation also plays a role in this process.
33945881	11	85	theme	wrinkle	2663:2669	arg1	determinant					2693:2703	the major determinant	2683:2703	the major determinant of cell alignment	2683:2721	Finally, we show that while wrinkle geometry is the major determinant of cell alignment, nanofiber orientation also plays a role in this process.
33945881	3	86	theme	process	819:825	arg1	geometry					785:792	geometry	785:792	geometry of the thermal wrinkling process	785:825	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	3	86	theme	process	819:825	arg1	speed					757:761	rotation speed	748:761	rotation speed of the collector	748:778	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	3	86	theme	process	819:825	arg1	time					723:726	the time	719:726	the time of electrospinning	719:745	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	1	87	theme	Structured	146:155	arg1	sheets					166:171	Structured hydrogel sheets	146:171	Structured hydrogel sheets	146:171	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	3	88	theme	thermal	801:807	arg1	process					819:825	the thermal wrinkling process	797:825	the thermal wrinkling process	797:825	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	6	89	theme	nano-structured	1676:1690	arg1	topographies					1692:1703	both micro- and nano-structured topographies	1660:1703	both micro- and nano-structured topographies	1660:1703	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	7	90	theme	tissues	1856:1862	arg1	morphology					1834:1843	the morphology	1830:1843	the morphology of natural tissues	1830:1862	STATEMENT OF SIGNIFICANCE: While structured hydrogels can mimic the morphology of natural tissues, controlling this morphology over multiple length scales remains challenging.
33945881	5	91	contain	had	1188:1190	arg2	effect					1202:1207	a smaller effect	1192:1207	a smaller effect	1192:1207	While the nanofiber orientation had a smaller effect on cell alignment, parallel nanofibers promoted improved cell alignment along the wrinkle direction while perpendicular nanofibers disrupted alignment.
33945881	5	91	contain	had	1188:1190	arg1	orientation					1176:1186	the nanofiber orientation	1162:1186	the nanofiber orientation	1162:1186	While the nanofiber orientation had a smaller effect on cell alignment, parallel nanofibers promoted improved cell alignment along the wrinkle direction while perpendicular nanofibers disrupted alignment.
33945881	11	92	theme	major	2687:2691	arg1	geometry					2671:2678	wrinkle geometry	2663:2678	wrinkle geometry	2663:2678	Finally, we show that while wrinkle geometry is the major determinant of cell alignment, nanofiber orientation also plays a role in this process.
33945881	11	92	theme	major	2687:2691	arg1	determinant					2693:2703	the major determinant	2683:2703	the major determinant of cell alignment	2683:2721	Finally, we show that while wrinkle geometry is the major determinant of cell alignment, nanofiber orientation also plays a role in this process.
33945881	3	93	theme	nanofiber	841:849	arg1	density					851:857	the hydrogel nanofiber density	828:857	the hydrogel nanofiber density	828:857	By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled.
33945881	6	94	theme	to-date	1472:1478	arg1	hydrogels					1462:1470	hydrogels	1462:1470	hydrogels to-date without requiring intensive micro/nanofabrication approaches	1462:1539	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	6	95	theme	micro-	1665:1670	arg1	topographies					1692:1703	both micro- and nano-structured topographies	1660:1703	both micro- and nano-structured topographies	1660:1703	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	2	96	theme	poly	548:551	arg1	sheets					619:624	nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets	534:624	nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	534:705	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	11	97	theme	alignment	2713:2721	arg1	geometry					2671:2678	wrinkle geometry	2663:2678	wrinkle geometry	2663:2678	Finally, we show that while wrinkle geometry is the major determinant of cell alignment, nanofiber orientation also plays a role in this process.
33945881	11	97	theme	alignment	2713:2721	arg1	determinant					2693:2703	the major determinant	2683:2703	the major determinant of cell alignment	2683:2721	Finally, we show that while wrinkle geometry is the major determinant of cell alignment, nanofiber orientation also plays a role in this process.
33945881	7	98	dep	STATEMENT	1766:1774	arg1	remains					1921:1927	remains	1921:1927	remains challenging	1921:1939	STATEMENT OF SIGNIFICANCE: While structured hydrogels can mimic the morphology of natural tissues, controlling this morphology over multiple length scales remains challenging.
33945881	4	99	from	orientation	1012:1022	arg1	sheets					1148:1153	uniaxially wrinkled sheets	1128:1153	uniaxially wrinkled sheets	1128:1153	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	4	99	from	orientation	1012:1022	arg1	sheets					1046:1051	biaxially wrinkled sheets	1027:1051	biaxially wrinkled sheets	1027:1051	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	4	99	from	orientation	1012:1022	arg1	morphology					1069:1078	an extended morphology	1057:1078	an extended morphology (directed preferentially along the wrinkles)	1057:1123	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	5	100	theme	wrinkle	1291:1297	arg1	direction					1299:1307	the wrinkle direction	1287:1307	the wrinkle direction	1287:1307	While the nanofiber orientation had a smaller effect on cell alignment, parallel nanofibers promoted improved cell alignment along the wrinkle direction while perpendicular nanofibers disrupted alignment.
33945881	8	101	theme	biomaterials	2132:2143	arg1	field					2112:2116	the field	2108:2116	the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions	2108:2209	Furthermore, the incorporation of secondary morphologies within individual hydrogels via simple manufacturing techniques would represent a significant advancement in the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions.
33945881	4	102	theme	random	1005:1010	arg1	orientation					1012:1022	a random orientation	1003:1022	a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets	1003:1153	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	0	103	theme	thermal	127:133	arg1	wrinkling					135:143	thermal wrinkling	127:143	thermal wrinkling	127:143	Multi-scale structuring of cell-instructive cellulose nanocrystal composite hydrogel sheets via sequential electrospinning and thermal wrinkling.
33945881	1	104	theme	multi-dimensional	375:391	arg1	cues					393:396	cells consistent multi-dimensional cues	358:396	cells consistent multi-dimensional cues	358:396	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	4	105	theme	mouse	967:971	arg1	cells					989:993	Adhered C2C12 mouse myoblast muscle cells	953:993	Adhered C2C12 mouse myoblast muscle cells	953:993	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	6	106	dep	in	1710:1711	arg1	vitro					1713:1717	vitro	1713:1717	vitro	1713:1717	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	2	107	theme	oligoethylene	553:565	arg1	poly					548:551	nanocomposite poly	534:551	nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	534:705	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	2	107	theme	oligoethylene	553:565	arg1	methacrylate					574:585	oligoethylene glycol methacrylate	553:585	oligoethylene glycol methacrylate	553:585	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	11	108	theme	nanofiber	2724:2732	arg1	orientation					2734:2744	nanofiber orientation	2724:2744	nanofiber orientation	2724:2744	Finally, we show that while wrinkle geometry is the major determinant of cell alignment, nanofiber orientation also plays a role in this process.
33945881	8	109	theme	complex	2173:2179	arg1	interactions					2198:2209	complex cell-biomaterial interactions	2173:2209	complex cell-biomaterial interactions	2173:2209	Furthermore, the incorporation of secondary morphologies within individual hydrogels via simple manufacturing techniques would represent a significant advancement in the field of structured biomaterials and an opportunity to study complex cell-biomaterial interactions.
33945881	6	110	theme	cell	1719:1722	arg1	screening					1724:1732	in vitro cell screening	1710:1732	in vitro cell screening	1710:1732	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	2	111	theme	sequential	475:484	arg1	electrospinning					486:500	sequential electrospinning	475:500	sequential electrospinning	475:500	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	1	112	dep	consistent	364:373	arg1	cells					358:362	cells	358:362	cells	358:362	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	0	113	theme	cell-instructive	27:42	arg1	cellulose					44:52	cell-instructive cellulose	27:52	cell-instructive cellulose	27:52	Multi-scale structuring of cell-instructive cellulose nanocrystal composite hydrogel sheets via sequential electrospinning and thermal wrinkling.
33945881	1	114	theme	such	308:311	arg1	sheets					313:318	such sheets	308:318	such sheets across multiple length scales to give cells consistent multi-dimensional cues	308:396	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	6	115	theme	in	1710:1711	arg1	screening					1724:1732	in vitro cell screening	1710:1732	in vitro cell screening	1710:1732	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	4	116	theme	extended	1060:1067	arg1	morphology					1069:1078	an extended morphology	1057:1078	an extended morphology (directed preferentially along the wrinkles)	1057:1123	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	2	117	theme	two-step	449:456	arg1	process					458:464	a simple two-step process	440:464	a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	440:705	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	6	118	theme	micro/nanofabrication	1508:1528	arg1	approaches					1530:1539	intensive micro/nanofabrication approaches	1498:1539	intensive micro/nanofabrication approaches	1498:1539	The highly tunable structures demonstrated are some of the most complex morphologies engineered into hydrogels to-date without requiring intensive micro/nanofabrication approaches and offer the potential to precisely regulate cell-substrate interactions in a "2.5D" environment (i.e. a surface with both micro- and nano-structured topographies) for in vitro cell screening or in vivo tissue regeneration.
33945881	7	119	theme	structured	1799:1808	arg1	hydrogels					1810:1818	structured hydrogels	1799:1818	structured hydrogels	1799:1818	STATEMENT OF SIGNIFICANCE: While structured hydrogels can mimic the morphology of natural tissues, controlling this morphology over multiple length scales remains challenging.
33945881	9	120	theme	two-step	2234:2241	arg1	process					2243:2249	a two-step process	2232:2249	a two-step process based on electrospinning and thermal wrinkling to prepare structured hydrogels with microscale wrinkles and nanoscale fibers	2232:2374	Herein, we leverage a two-step process based on electrospinning and thermal wrinkling to prepare structured hydrogels with microscale wrinkles and nanoscale fibers.
33945881	4	121	theme	muscle	982:987	arg1	cells					989:993	Adhered C2C12 mouse myoblast muscle cells	953:993	Adhered C2C12 mouse myoblast muscle cells	953:993	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	0	122	theme	hydrogel	76:83	arg1	sheets					85:90	composite hydrogel sheets	66:90	composite hydrogel sheets	66:90	Multi-scale structuring of cell-instructive cellulose nanocrystal composite hydrogel sheets via sequential electrospinning and thermal wrinkling.
33945881	1	123	theme	length	336:341	arg1	scales					343:348	multiple length scales	327:348	multiple length scales	327:348	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	4	124	theme	wrinkled	1037:1044	arg1	sheets					1046:1051	biaxially wrinkled sheets	1027:1051	biaxially wrinkled sheets	1027:1051	Adhered C2C12 mouse myoblast muscle cells display a random orientation on biaxially wrinkled sheets but an extended morphology (directed preferentially along the wrinkles) on uniaxially wrinkled sheets.
33945881	1	125	dep	mechanics	206:214	arg1	the					202:204	the	202:204	the	202:204	Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging.
33945881	2	126	with	sheets	619:624	arg1	morphology					696:705	a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	631:705	morphology	696:705	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	2	126	with	sheets	619:624	arg1	micro					670:674	a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology	631:705	micro	670:674	Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology.
33945881	9	127	with	hydrogels	2320:2328	arg1	wrinkles					2346:2353	microscale wrinkles	2335:2353	microscale wrinkles	2335:2353	Herein, we leverage a two-step process based on electrospinning and thermal wrinkling to prepare structured hydrogels with microscale wrinkles and nanoscale fibers.
33945881	9	127	with	hydrogels	2320:2328	arg1	fibers					2369:2374	nanoscale fibers	2359:2374	nanoscale fibers	2359:2374	Herein, we leverage a two-step process based on electrospinning and thermal wrinkling to prepare structured hydrogels with microscale wrinkles and nanoscale fibers.
33945881	9	128	theme	thermal	2280:2286	arg1	wrinkling					2288:2296	thermal wrinkling	2280:2296	thermal wrinkling	2280:2296	Herein, we leverage a two-step process based on electrospinning and thermal wrinkling to prepare structured hydrogels with microscale wrinkles and nanoscale fibers.
32194841	8	0	dep	in	1163:1164	arg1	vivo					1166:1169	vivo	1166:1169	vivo	1166:1169	Both the in vitro and in vivo experiments showed that GM-HPCH + TGFβ1 shifted the recruited macrophages from M1 to M2 and promoted chondrogenic gene expression.
32194841	6	1	theme	composite	1018:1026	arg1	hydrogel					1028:1035	the composite hydrogel	1014:1035	the composite hydrogel	1014:1035	The macrophage immunomodulation, MSC recruitment and chondrogenesis of the composite hydrogel were evaluated.
32194841	11	2	theme	cartilage	1703:1711	arg1	healing					1713:1719	superior cartilage healing	1694:1719	superior cartilage healing	1694:1719	The macroscopic evaluation and histological results at 6 weeks and 12 weeks postsurgery showed that GM-HPCH + TGFβ1 can achieve superior cartilage healing.
32194841	1	3	theme	thermosensitive	199:213	arg1	hydrogels					215:223	thermosensitive hydrogels	199:223	thermosensitive hydrogels	199:223	Repairing cartilage defects using thermosensitive hydrogels is an attractive treatment strategy, but the poor mechanical properties and limited understanding of the interactions between hydrogels and cells limit their application.
32194841	1	4	theme	limited	301:307	arg1	understanding					309:321	limited understanding	301:321	limited understanding	301:321	Repairing cartilage defects using thermosensitive hydrogels is an attractive treatment strategy, but the poor mechanical properties and limited understanding of the interactions between hydrogels and cells limit their application.
32194841	2	5	theme	methacrylate-modified	561:581	arg1	GM-HPCH					589:595	GM-HPCH	589:595	GM-HPCH	589:595	Methods: In this study, a thermosensitive hydroxypropyl chitin hydrogel (HPCH) was functionalized with methacrylate groups to synthesize photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH).
32194841	2	5	theme	methacrylate-modified	561:581	arg1	HPCH					583:586	photocrosslinkable glycidyl methacrylate-modified HPCH	533:586	photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH)	533:596	Methods: In this study, a thermosensitive hydroxypropyl chitin hydrogel (HPCH) was functionalized with methacrylate groups to synthesize photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH).
32194841	7	6	theme	high	1067:1070	arg1	biocompatibility					1072:1087	high biocompatibility	1067:1087	high biocompatibility	1067:1087	Results: With high biocompatibility, GM-HPCH could protect chondrocytes from apoptosis.
32194841	10	7	theme	chondral	1524:1531	arg1	defect					1533:1538	the rat chondral defect	1516:1538	the rat chondral defect	1516:1538	The fluorescent tracking of MSCs confirmed MSC homing in the rat chondral defect with the help of GM-HPCH.
32194841	11	8	theme	histological	1597:1608	arg1	results					1610:1616	histological results	1597:1616	histological results	1597:1616	The macroscopic evaluation and histological results at 6 weeks and 12 weeks postsurgery showed that GM-HPCH + TGFβ1 can achieve superior cartilage healing.
32194841	3	9	theme	UV	726:727	arg1	irradiation					729:739	UV irradiation	726:739	UV irradiation	726:739	GM-HPCH could form a gel in situ through a thermosensitive sol-gel transition and its mechanical properties can be improved by UV irradiation.
32194841	11	10	dep	evaluation	1582:1591	arg1	The					1566:1568	The	1566:1568	The	1566:1568	The macroscopic evaluation and histological results at 6 weeks and 12 weeks postsurgery showed that GM-HPCH + TGFβ1 can achieve superior cartilage healing.
32194841	12	11	theme	injectable	1905:1914	arg1	hydrogel					1916:1923	a promising injectable hydrogel	1893:1923	a promising injectable hydrogel for cartilage regeneration	1893:1950	Conclusions: The GM-HPCH + TGFβ1 hydrogel effectively promoted cartilage repair via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis; thus it is a promising injectable hydrogel for cartilage regeneration.
32194841	12	11	theme	injectable	1905:1914	arg1	it					1887:1888	it	1887:1888	it	1887:1888	Conclusions: The GM-HPCH + TGFβ1 hydrogel effectively promoted cartilage repair via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis; thus it is a promising injectable hydrogel for cartilage regeneration.
32194841	8	12	dep	in	1150:1151	arg1	vitro					1153:1157	vitro	1153:1157	vitro	1153:1157	Both the in vitro and in vivo experiments showed that GM-HPCH + TGFβ1 shifted the recruited macrophages from M1 to M2 and promoted chondrogenic gene expression.
32194841	8	13	theme	in	1150:1151	arg1	experiments					1171:1181	Both the in vitro and in vivo experiments	1141:1181	experiments	1171:1181	Both the in vitro and in vivo experiments showed that GM-HPCH + TGFβ1 shifted the recruited macrophages from M1 to M2 and promoted chondrogenic gene expression.
32194841	10	14	theme	MSCs	1487:1490	arg1	tracking					1475:1482	The fluorescent tracking	1459:1482	The fluorescent tracking of MSCs	1459:1490	The fluorescent tracking of MSCs confirmed MSC homing in the rat chondral defect with the help of GM-HPCH.
32194841	4	15	theme	anti-apoptosis	776:789	arg1	activity					791:798	anti-apoptosis activity	776:798	anti-apoptosis activity	776:798	Cell viability, cell adhesion and anti-apoptosis activity of GM-HPCH were evaluated.
32194841	12	16	theme	TGFβ1	1749:1753	arg1	hydrogel					1755:1762	The GM-HPCH + TGFβ1 hydrogel	1735:1762	The GM-HPCH + TGFβ1 hydrogel	1735:1762	Conclusions: The GM-HPCH + TGFβ1 hydrogel effectively promoted cartilage repair via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis; thus it is a promising injectable hydrogel for cartilage regeneration.
32194841	4	17	theme	GM-HPCH	803:809	arg1	viability					747:755	Cell viability	742:755	Cell viability	742:755	Cell viability, cell adhesion and anti-apoptosis activity of GM-HPCH were evaluated.
32194841	4	17	theme	GM-HPCH	803:809	arg1	adhesion					763:770	cell adhesion	758:770	cell adhesion	758:770	Cell viability, cell adhesion and anti-apoptosis activity of GM-HPCH were evaluated.
32194841	4	17	theme	GM-HPCH	803:809	arg1	activity					791:798	anti-apoptosis activity	776:798	anti-apoptosis activity	776:798	Cell viability, cell adhesion and anti-apoptosis activity of GM-HPCH were evaluated.
32194841	5	18	theme	Transforming	827:838	arg1	TGFβ1					858:862	TGFβ1	858:862	TGFβ1	858:862	Transforming growth factor-β1 (TGFβ1) was introduced into the GM-HPCH hydrogel to fabricate the composite hydrogel.
32194841	5	18	theme	Transforming	827:838	arg1	factor-β1					847:855	Transforming growth factor-β1	827:855	Transforming growth factor-β1 (TGFβ1)	827:863	Transforming growth factor-β1 (TGFβ1) was introduced into the GM-HPCH hydrogel to fabricate the composite hydrogel.
32194841	9	19	theme	Transwell	1405:1413	arg1	test					1415:1418	the Transwell test	1401:1418	the Transwell test	1401:1418	Additionally, the composite hydrogel could promote the migration of marrow stromal cells (MSCs) in the Transwell test and increase migrated gene expression.
32194841	8	20	theme	chondrogenic	1272:1283	arg1	expression					1290:1299	chondrogenic gene expression	1272:1299	chondrogenic gene expression	1272:1299	Both the in vitro and in vivo experiments showed that GM-HPCH + TGFβ1 shifted the recruited macrophages from M1 to M2 and promoted chondrogenic gene expression.
32194841	11	21	theme	postsurgery	1642:1652	arg1	weeks					1636:1640	12 weeks postsurgery	1633:1652	12 weeks postsurgery	1633:1652	The macroscopic evaluation and histological results at 6 weeks and 12 weeks postsurgery showed that GM-HPCH + TGFβ1 can achieve superior cartilage healing.
32194841	1	22	theme	attractive	231:240	arg1	strategy					252:259	an attractive treatment strategy	228:259	an attractive treatment strategy	228:259	Repairing cartilage defects using thermosensitive hydrogels is an attractive treatment strategy, but the poor mechanical properties and limited understanding of the interactions between hydrogels and cells limit their application.
32194841	4	23	theme	Cell	742:745	arg1	viability					747:755	Cell viability	742:755	Cell viability	742:755	Cell viability, cell adhesion and anti-apoptosis activity of GM-HPCH were evaluated.
32194841	5	24	theme	growth	840:845	arg1	TGFβ1					858:862	TGFβ1	858:862	TGFβ1	858:862	Transforming growth factor-β1 (TGFβ1) was introduced into the GM-HPCH hydrogel to fabricate the composite hydrogel.
32194841	5	24	theme	growth	840:845	arg1	factor-β1					847:855	Transforming growth factor-β1	827:855	Transforming growth factor-β1 (TGFβ1)	827:863	Transforming growth factor-β1 (TGFβ1) was introduced into the GM-HPCH hydrogel to fabricate the composite hydrogel.
32194841	2	25	theme	glycidyl	552:559	arg1	GM-HPCH					589:595	GM-HPCH	589:595	GM-HPCH	589:595	Methods: In this study, a thermosensitive hydroxypropyl chitin hydrogel (HPCH) was functionalized with methacrylate groups to synthesize photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH).
32194841	2	25	theme	glycidyl	552:559	arg1	HPCH					583:586	photocrosslinkable glycidyl methacrylate-modified HPCH	533:586	photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH)	533:596	Methods: In this study, a thermosensitive hydroxypropyl chitin hydrogel (HPCH) was functionalized with methacrylate groups to synthesize photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH).
32194841	10	26	theme	rat	1520:1522	arg1	defect					1533:1538	the rat chondral defect	1516:1538	the rat chondral defect	1516:1538	The fluorescent tracking of MSCs confirmed MSC homing in the rat chondral defect with the help of GM-HPCH.
32194841	2	27	theme	methacrylate	499:510	arg1	groups					512:517	methacrylate groups	499:517	methacrylate groups	499:517	Methods: In this study, a thermosensitive hydroxypropyl chitin hydrogel (HPCH) was functionalized with methacrylate groups to synthesize photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH).
32194841	2	28	theme	chitin	452:457	arg1	HPCH					469:472	HPCH	469:472	HPCH	469:472	Methods: In this study, a thermosensitive hydroxypropyl chitin hydrogel (HPCH) was functionalized with methacrylate groups to synthesize photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH).
32194841	2	28	theme	chitin	452:457	arg1	hydrogel					459:466	a thermosensitive hydroxypropyl chitin hydrogel	420:466	a thermosensitive hydroxypropyl chitin hydrogel (HPCH)	420:473	Methods: In this study, a thermosensitive hydroxypropyl chitin hydrogel (HPCH) was functionalized with methacrylate groups to synthesize photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH).
32194841	5	29	theme	GM-HPCH	889:895	arg1	hydrogel					897:904	the GM-HPCH hydrogel	885:904	the GM-HPCH hydrogel to fabricate the composite hydrogel	885:940	Transforming growth factor-β1 (TGFβ1) was introduced into the GM-HPCH hydrogel to fabricate the composite hydrogel.
32194841	6	30	theme	MSC	976:978	arg1	recruitment					980:990	MSC recruitment	976:990	MSC recruitment	976:990	The macrophage immunomodulation, MSC recruitment and chondrogenesis of the composite hydrogel were evaluated.
32194841	8	31	dep	experiments	1171:1181	arg1	Both					1141:1144	Both	1141:1144	Both	1141:1144	Both the in vitro and in vivo experiments showed that GM-HPCH + TGFβ1 shifted the recruited macrophages from M1 to M2 and promoted chondrogenic gene expression.
32194841	2	32	theme	hydroxypropyl	438:450	arg1	HPCH					469:472	HPCH	469:472	HPCH	469:472	Methods: In this study, a thermosensitive hydroxypropyl chitin hydrogel (HPCH) was functionalized with methacrylate groups to synthesize photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH).
32194841	2	32	theme	hydroxypropyl	438:450	arg1	hydrogel					459:466	a thermosensitive hydroxypropyl chitin hydrogel	420:466	a thermosensitive hydroxypropyl chitin hydrogel (HPCH)	420:473	Methods: In this study, a thermosensitive hydroxypropyl chitin hydrogel (HPCH) was functionalized with methacrylate groups to synthesize photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH).
32194841	0	33	theme	Cartilage	0:8	arg1	repair					10:15	Cartilage repair	0:15	Cartilage repair	0:15	Cartilage repair mediated by thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis.
32194841	1	34	theme	interactions	330:341	arg1	properties					286:295	poor mechanical properties	270:295	poor mechanical properties	270:295	Repairing cartilage defects using thermosensitive hydrogels is an attractive treatment strategy, but the poor mechanical properties and limited understanding of the interactions between hydrogels and cells limit their application.
32194841	1	34	theme	interactions	330:341	arg1	understanding					309:321	limited understanding	301:321	limited understanding	301:321	Repairing cartilage defects using thermosensitive hydrogels is an attractive treatment strategy, but the poor mechanical properties and limited understanding of the interactions between hydrogels and cells limit their application.
32194841	9	35	theme	composite	1320:1328	arg1	hydrogel					1330:1337	the composite hydrogel	1316:1337	the composite hydrogel	1316:1337	Additionally, the composite hydrogel could promote the migration of marrow stromal cells (MSCs) in the Transwell test and increase migrated gene expression.
32194841	3	36	theme	thermosensitive	642:656	arg1	transition					666:675	a thermosensitive sol-gel transition	640:675	a thermosensitive sol-gel transition	640:675	GM-HPCH could form a gel in situ through a thermosensitive sol-gel transition and its mechanical properties can be improved by UV irradiation.
32194841	2	37	theme	thermosensitive	422:436	arg1	HPCH					469:472	HPCH	469:472	HPCH	469:472	Methods: In this study, a thermosensitive hydroxypropyl chitin hydrogel (HPCH) was functionalized with methacrylate groups to synthesize photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH).
32194841	2	37	theme	thermosensitive	422:436	arg1	hydrogel					459:466	a thermosensitive hydroxypropyl chitin hydrogel	420:466	a thermosensitive hydroxypropyl chitin hydrogel (HPCH)	420:473	Methods: In this study, a thermosensitive hydroxypropyl chitin hydrogel (HPCH) was functionalized with methacrylate groups to synthesize photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH).
32194841	9	38	theme	migrated	1433:1440	arg1	expression					1447:1456	migrated gene expression	1433:1456	migrated gene expression	1433:1456	Additionally, the composite hydrogel could promote the migration of marrow stromal cells (MSCs) in the Transwell test and increase migrated gene expression.
32194841	12	39	dep	promoted	1776:1783	arg1	promoting					1856:1864	promoting	1856:1864	promoting chondrogenesis	1856:1879	Conclusions: The GM-HPCH + TGFβ1 hydrogel effectively promoted cartilage repair via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis; thus it is a promising injectable hydrogel for cartilage regeneration.
32194841	12	39	dep	promoted	1776:1783	arg1	recruiting					1836:1845	recruiting	1836:1845	recruiting MSCs	1836:1850	Conclusions: The GM-HPCH + TGFβ1 hydrogel effectively promoted cartilage repair via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis; thus it is a promising injectable hydrogel for cartilage regeneration.
32194841	8	40	theme	in	1163:1164	arg1	experiments					1171:1181	Both the in vitro and in vivo experiments	1141:1181	experiments	1171:1181	Both the in vitro and in vivo experiments showed that GM-HPCH + TGFβ1 shifted the recruited macrophages from M1 to M2 and promoted chondrogenic gene expression.
32194841	10	41	theme	MSC	1502:1504	arg1	homing					1506:1511	MSC homing	1502:1511	MSC homing	1502:1511	The fluorescent tracking of MSCs confirmed MSC homing in the rat chondral defect with the help of GM-HPCH.
32194841	9	42	theme	gene	1442:1445	arg1	expression					1447:1456	migrated gene expression	1433:1456	migrated gene expression	1433:1456	Additionally, the composite hydrogel could promote the migration of marrow stromal cells (MSCs) in the Transwell test and increase migrated gene expression.
32194841	1	43	dep	properties	286:295	arg1	the					266:268	the	266:268	the	266:268	Repairing cartilage defects using thermosensitive hydrogels is an attractive treatment strategy, but the poor mechanical properties and limited understanding of the interactions between hydrogels and cells limit their application.
32194841	11	44	from	weeks	1636:1640	arg1	evaluation					1582:1591	macroscopic evaluation	1570:1591	macroscopic evaluation	1570:1591	The macroscopic evaluation and histological results at 6 weeks and 12 weeks postsurgery showed that GM-HPCH + TGFβ1 can achieve superior cartilage healing.
32194841	11	44	from	weeks	1636:1640	arg1	results					1610:1616	histological results	1597:1616	histological results	1597:1616	The macroscopic evaluation and histological results at 6 weeks and 12 weeks postsurgery showed that GM-HPCH + TGFβ1 can achieve superior cartilage healing.
32194841	12	45	theme	GM-HPCH	1739:1745	arg1	hydrogel					1755:1762	The GM-HPCH + TGFβ1 hydrogel	1735:1762	The GM-HPCH + TGFβ1 hydrogel	1735:1762	Conclusions: The GM-HPCH + TGFβ1 hydrogel effectively promoted cartilage repair via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis; thus it is a promising injectable hydrogel for cartilage regeneration.
32194841	5	46	theme	composite	923:931	arg1	hydrogel					933:940	the composite hydrogel	919:940	the composite hydrogel	919:940	Transforming growth factor-β1 (TGFβ1) was introduced into the GM-HPCH hydrogel to fabricate the composite hydrogel.
32194841	0	47	theme	photocrosslinkable	45:62	arg1	GM-HPCH					77:83	thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH	29:83	thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages	29:116	Cartilage repair mediated by thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis.
32194841	8	48	from	M1	1250:1251	arg1	macrophages					1233:1243	the recruited macrophages	1219:1243	the recruited macrophages from M1	1219:1251	Both the in vitro and in vivo experiments showed that GM-HPCH + TGFβ1 shifted the recruited macrophages from M1 to M2 and promoted chondrogenic gene expression.
32194841	1	49	theme	treatment	242:250	arg1	strategy					252:259	an attractive treatment strategy	228:259	an attractive treatment strategy	228:259	Repairing cartilage defects using thermosensitive hydrogels is an attractive treatment strategy, but the poor mechanical properties and limited understanding of the interactions between hydrogels and cells limit their application.
32194841	2	50	theme	photocrosslinkable	533:550	arg1	GM-HPCH					589:595	GM-HPCH	589:595	GM-HPCH	589:595	Methods: In this study, a thermosensitive hydroxypropyl chitin hydrogel (HPCH) was functionalized with methacrylate groups to synthesize photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH).
32194841	2	50	theme	photocrosslinkable	533:550	arg1	HPCH					583:586	photocrosslinkable glycidyl methacrylate-modified HPCH	533:586	photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH)	533:596	Methods: In this study, a thermosensitive hydroxypropyl chitin hydrogel (HPCH) was functionalized with methacrylate groups to synthesize photocrosslinkable glycidyl methacrylate-modified HPCH (GM-HPCH).
32194841	0	51	theme	thermosensitive	29:43	arg1	GM-HPCH					77:83	thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH	29:83	thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages	29:116	Cartilage repair mediated by thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis.
32194841	6	52	theme	macrophage	947:956	arg1	immunomodulation					958:973	macrophage immunomodulation	947:973	macrophage immunomodulation	947:973	The macrophage immunomodulation, MSC recruitment and chondrogenesis of the composite hydrogel were evaluated.
32194841	12	53	theme	cartilage	1929:1937	arg1	regeneration					1939:1950	cartilage regeneration	1929:1950	cartilage regeneration	1929:1950	Conclusions: The GM-HPCH + TGFβ1 hydrogel effectively promoted cartilage repair via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis; thus it is a promising injectable hydrogel for cartilage regeneration.
32194841	10	54	dep	the	1545:1547	arg1	help					1549:1552	help	1549:1552	help	1549:1552	The fluorescent tracking of MSCs confirmed MSC homing in the rat chondral defect with the help of GM-HPCH.
32194841	3	55	theme	sol-gel	658:664	arg1	transition					666:675	a thermosensitive sol-gel transition	640:675	a thermosensitive sol-gel transition	640:675	GM-HPCH could form a gel in situ through a thermosensitive sol-gel transition and its mechanical properties can be improved by UV irradiation.
32194841	0	56	theme	TGFβ1-loaded	64:75	arg1	GM-HPCH					77:83	thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH	29:83	thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages	29:116	Cartilage repair mediated by thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis.
32194841	8	57	theme	recruited	1223:1231	arg1	macrophages					1233:1243	the recruited macrophages	1219:1243	the recruited macrophages from M1	1219:1251	Both the in vitro and in vivo experiments showed that GM-HPCH + TGFβ1 shifted the recruited macrophages from M1 to M2 and promoted chondrogenic gene expression.
32194841	9	58	theme	marrow	1370:1375	arg1	MSCs					1392:1395	MSCs	1392:1395	MSCs	1392:1395	Additionally, the composite hydrogel could promote the migration of marrow stromal cells (MSCs) in the Transwell test and increase migrated gene expression.
32194841	9	58	theme	marrow	1370:1375	arg1	cells					1385:1389	marrow stromal cells	1370:1389	marrow stromal cells (MSCs)	1370:1396	Additionally, the composite hydrogel could promote the migration of marrow stromal cells (MSCs) in the Transwell test and increase migrated gene expression.
32194841	12	59	theme	immunomodulating	1806:1821	arg1	macrophages					1823:1833	immunomodulating macrophages	1806:1833	immunomodulating macrophages	1806:1833	Conclusions: The GM-HPCH + TGFβ1 hydrogel effectively promoted cartilage repair via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis; thus it is a promising injectable hydrogel for cartilage regeneration.
32194841	1	60	theme	poor	270:273	arg1	properties					286:295	poor mechanical properties	270:295	poor mechanical properties	270:295	Repairing cartilage defects using thermosensitive hydrogels is an attractive treatment strategy, but the poor mechanical properties and limited understanding of the interactions between hydrogels and cells limit their application.
32194841	9	61	theme	stromal	1377:1383	arg1	MSCs					1392:1395	MSCs	1392:1395	MSCs	1392:1395	Additionally, the composite hydrogel could promote the migration of marrow stromal cells (MSCs) in the Transwell test and increase migrated gene expression.
32194841	9	61	theme	stromal	1377:1383	arg1	cells					1385:1389	marrow stromal cells	1370:1389	marrow stromal cells (MSCs)	1370:1396	Additionally, the composite hydrogel could promote the migration of marrow stromal cells (MSCs) in the Transwell test and increase migrated gene expression.
32194841	8	62	theme	gene	1285:1288	arg1	expression					1290:1299	chondrogenic gene expression	1272:1299	chondrogenic gene expression	1272:1299	Both the in vitro and in vivo experiments showed that GM-HPCH + TGFβ1 shifted the recruited macrophages from M1 to M2 and promoted chondrogenic gene expression.
32194841	12	63	theme	promising	1895:1903	arg1	hydrogel					1916:1923	a promising injectable hydrogel	1893:1923	a promising injectable hydrogel for cartilage regeneration	1893:1950	Conclusions: The GM-HPCH + TGFβ1 hydrogel effectively promoted cartilage repair via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis; thus it is a promising injectable hydrogel for cartilage regeneration.
32194841	12	63	theme	promising	1895:1903	arg1	it					1887:1888	it	1887:1888	it	1887:1888	Conclusions: The GM-HPCH + TGFβ1 hydrogel effectively promoted cartilage repair via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis; thus it is a promising injectable hydrogel for cartilage regeneration.
32194841	1	64	theme	cartilage	175:183	arg1	defects					185:191	cartilage defects	175:191	cartilage defects using thermosensitive hydrogels	175:223	Repairing cartilage defects using thermosensitive hydrogels is an attractive treatment strategy, but the poor mechanical properties and limited understanding of the interactions between hydrogels and cells limit their application.
32194841	1	65	theme	mechanical	275:284	arg1	properties					286:295	poor mechanical properties	270:295	poor mechanical properties	270:295	Repairing cartilage defects using thermosensitive hydrogels is an attractive treatment strategy, but the poor mechanical properties and limited understanding of the interactions between hydrogels and cells limit their application.
32194841	0	66	theme	immunomodulating	89:104	arg1	macrophages					106:116	immunomodulating macrophages	89:116	immunomodulating macrophages	89:116	Cartilage repair mediated by thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis.
32194841	9	67	theme	cells	1385:1389	arg1	migration					1357:1365	the migration	1353:1365	the migration of marrow stromal cells (MSCs) in the Transwell test	1353:1418	Additionally, the composite hydrogel could promote the migration of marrow stromal cells (MSCs) in the Transwell test and increase migrated gene expression.
32194841	3	68	theme	mechanical	685:694	arg1	properties					696:705	its mechanical properties	681:705	its mechanical properties	681:705	GM-HPCH could form a gel in situ through a thermosensitive sol-gel transition and its mechanical properties can be improved by UV irradiation.
32194841	10	69	theme	fluorescent	1463:1473	arg1	tracking					1475:1482	The fluorescent tracking	1459:1482	The fluorescent tracking of MSCs	1459:1490	The fluorescent tracking of MSCs confirmed MSC homing in the rat chondral defect with the help of GM-HPCH.
32194841	11	70	from	weeks	1623:1627	arg1	evaluation					1582:1591	macroscopic evaluation	1570:1591	macroscopic evaluation	1570:1591	The macroscopic evaluation and histological results at 6 weeks and 12 weeks postsurgery showed that GM-HPCH + TGFβ1 can achieve superior cartilage healing.
32194841	11	70	from	weeks	1623:1627	arg1	results					1610:1616	histological results	1597:1616	histological results	1597:1616	The macroscopic evaluation and histological results at 6 weeks and 12 weeks postsurgery showed that GM-HPCH + TGFβ1 can achieve superior cartilage healing.
32194841	11	71	theme	macroscopic	1570:1580	arg1	evaluation					1582:1591	macroscopic evaluation	1570:1591	macroscopic evaluation	1570:1591	The macroscopic evaluation and histological results at 6 weeks and 12 weeks postsurgery showed that GM-HPCH + TGFβ1 can achieve superior cartilage healing.
32194841	6	72	theme	hydrogel	1028:1035	arg1	chondrogenesis					996:1009	chondrogenesis	996:1009	chondrogenesis	996:1009	The macrophage immunomodulation, MSC recruitment and chondrogenesis of the composite hydrogel were evaluated.
32194841	6	72	theme	hydrogel	1028:1035	arg1	immunomodulation					958:973	macrophage immunomodulation	947:973	macrophage immunomodulation	947:973	The macrophage immunomodulation, MSC recruitment and chondrogenesis of the composite hydrogel were evaluated.
32194841	6	72	theme	hydrogel	1028:1035	arg1	recruitment					980:990	MSC recruitment	976:990	MSC recruitment	976:990	The macrophage immunomodulation, MSC recruitment and chondrogenesis of the composite hydrogel were evaluated.
32194841	11	73	theme	superior	1694:1701	arg1	healing					1713:1719	superior cartilage healing	1694:1719	superior cartilage healing	1694:1719	The macroscopic evaluation and histological results at 6 weeks and 12 weeks postsurgery showed that GM-HPCH + TGFβ1 can achieve superior cartilage healing.
32194841	4	74	theme	cell	758:761	arg1	adhesion					763:770	cell adhesion	758:770	cell adhesion	758:770	Cell viability, cell adhesion and anti-apoptosis activity of GM-HPCH were evaluated.
32194841	12	75	theme	cartilage	1785:1793	arg1	repair					1795:1800	cartilage repair	1785:1800	cartilage repair	1785:1800	Conclusions: The GM-HPCH + TGFβ1 hydrogel effectively promoted cartilage repair via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis; thus it is a promising injectable hydrogel for cartilage regeneration.
32194841	9	76	from	migration	1357:1365	arg1	test					1415:1418	the Transwell test	1401:1418	the Transwell test	1401:1418	Additionally, the composite hydrogel could promote the migration of marrow stromal cells (MSCs) in the Transwell test and increase migrated gene expression.
33901028	0	0	theme	starch/OMMT	78:88	arg1	composite					90:98	starch/OMMT composite	78:98	starch/OMMT composite	78:98	Nature of sorption of trivalent arsenic on novel iron oxyhydroxide stabilized starch/OMMT composite: A mechanistic approach.
33901028	0	1	from	sorption	10:17	arg1	oxyhydroxide					54:65	novel iron oxyhydroxide	43:65	novel iron oxyhydroxide	43:65	Nature of sorption of trivalent arsenic on novel iron oxyhydroxide stabilized starch/OMMT composite: A mechanistic approach.
33901028	5	2	theme	above	768:772	arg1	findings					774:781	the above findings	764:781	the above findings	764:781	A molecular modeling on the basis of density functional theory was carried out to verify the above findings.
33901028	9	3	theme	monolayer	1237:1245	arg1	pattern					1261:1267	a monolayer chemisorption pattern	1235:1267	a monolayer chemisorption pattern	1235:1267	The sorption followed a monolayer chemisorption pattern as determined by the Langmuir model (R2 = 0.973, R L = 0.081) with a qmax = 2.04 at 303 K.
33901028	2	4	theme	clay	338:341	arg1	SICC					282:285	SICC	282:285	SICC	282:285	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	2	4	theme	clay	338:341	arg1	material					272:279	a hybrid material	263:279	a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay	263:341	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	10	5	theme	III	1378:1380	arg1	binding					1364:1370	The binding	1360:1370	The binding of As(III) on the material	1360:1397	The binding of As(III) on the material was governed by a pseudo second order kinetic model.
33901028	6	6	theme	sorption	896:903	arg1	extent					886:891	extent	886:891	extent of sorption	886:903	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	2	7	theme	OMMT	333:336	arg1	clay					338:341	OMMT clay	333:341	OMMT clay	333:341	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	6	8	theme	varying	855:861	arg1	temperatures					863:874	varying temperatures	855:874	varying temperatures	855:874	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	6	8	theme	varying	855:861	arg1	dose					806:809	material dose	797:809	material dose	797:809	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	4	9	theme	arsenic	580:586	arg1	sorption					588:595	arsenic sorption	580:595	arsenic sorption	580:595	All binding interactions during material preparation and arsenic sorption were exclusively characterized with FT-IR, XRD and other spectroscopic tools.
33901028	0	10	from	Nature	0:5	arg1	oxyhydroxide					54:65	novel iron oxyhydroxide	43:65	novel iron oxyhydroxide	43:65	Nature of sorption of trivalent arsenic on novel iron oxyhydroxide stabilized starch/OMMT composite: A mechanistic approach.
33901028	6	11	theme	treatment	812:820	arg1	dose					806:809	material dose	797:809	material dose	797:809	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	6	11	theme	treatment	812:820	arg1	time					822:825	treatment time	812:825	treatment time	812:825	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	5	12	theme	molecular	677:685	arg1	modeling					687:694	A molecular modeling	675:694	A molecular modeling on the basis of density functional theory	675:736	A molecular modeling on the basis of density functional theory was carried out to verify the above findings.
33901028	7	13	theme	thermodynamic	932:944	arg1	parameters					946:955	The thermodynamic parameters	928:955	The thermodynamic parameters	928:955	The thermodynamic parameters viz.
33901028	9	14	theme	=	1343:1343	arg1	2.04					1345:1348	a qmax = 2.04	1336:1348	a qmax = 2.04 at 303 K	1336:1357	The sorption followed a monolayer chemisorption pattern as determined by the Langmuir model (R2 = 0.973, R L = 0.081) with a qmax = 2.04 at 303 K.
33901028	0	15	theme	mechanistic	103:113	arg1	approach					115:122	A mechanistic approach	101:122	A mechanistic approach	101:122	Nature of sorption of trivalent arsenic on novel iron oxyhydroxide stabilized starch/OMMT composite: A mechanistic approach.
33901028	9	16	dep	model	1299:1303	arg1	=					1322:1322	=	1322:1322	=	1322:1322	The sorption followed a monolayer chemisorption pattern as determined by the Langmuir model (R2 = 0.973, R L = 0.081) with a qmax = 2.04 at 303 K.
33901028	6	17	theme	dose	806:809	arg1	Influence					784:792	Influence	784:792	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption	784:903	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	8	18	theme	process	1078:1084	arg1	behavior					1103:1110	its endothermic behavior	1087:1110	its endothermic behavior	1087:1110	ΔG (>-11 kJ/mol), ΔH (42.48 kJ/mol), ΔS (177.6 JK-1 mol-1) and E a (59.16 kJ/mol) determined the feasibility of the process, its endothermic behavior and most importantly the chemical nature of the sorption accompanied by ion-exchange to some extent.
33901028	8	18	theme	process	1078:1084	arg1	nature					1146:1151	the chemical nature	1133:1151	the chemical nature of the sorption accompanied by ion-exchange to some extent	1133:1210	ΔG (>-11 kJ/mol), ΔH (42.48 kJ/mol), ΔS (177.6 JK-1 mol-1) and E a (59.16 kJ/mol) determined the feasibility of the process, its endothermic behavior and most importantly the chemical nature of the sorption accompanied by ion-exchange to some extent.
33901028	8	18	theme	process	1078:1084	arg1	feasibility					1059:1069	the feasibility	1055:1069	the feasibility of the process	1055:1084	ΔG (>-11 kJ/mol), ΔH (42.48 kJ/mol), ΔS (177.6 JK-1 mol-1) and E a (59.16 kJ/mol) determined the feasibility of the process, its endothermic behavior and most importantly the chemical nature of the sorption accompanied by ion-exchange to some extent.
33901028	9	19	theme	R	1318:1318	arg1	L					1320:1320	R L	1318:1320	R L	1318:1320	The sorption followed a monolayer chemisorption pattern as determined by the Langmuir model (R2 = 0.973, R L = 0.081) with a qmax = 2.04 at 303 K.
33901028	3	20	theme	new	393:395	arg1	material					397:404	This new material	388:404	This new material	388:404	This new material was highly efficient in arsenic water treatment which could reduce arsenic concentration far below detection limits.
33901028	6	21	theme	material	797:804	arg1	etc.					877:880	etc.	877:880	etc.	877:880	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	6	21	theme	material	797:804	arg1	concentration					840:852	initial ion concentration	828:852	initial ion concentration	828:852	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	6	21	theme	material	797:804	arg1	temperatures					863:874	varying temperatures	855:874	varying temperatures	855:874	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	6	21	theme	material	797:804	arg1	dose					806:809	material dose	797:809	material dose	797:809	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	6	21	theme	material	797:804	arg1	time					822:825	treatment time	812:825	treatment time	812:825	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	10	22	theme	second	1424:1429	arg1	model					1445:1449	a pseudo second order kinetic model	1415:1449	a pseudo second order kinetic model	1415:1449	The binding of As(III) on the material was governed by a pseudo second order kinetic model.
33901028	2	23	theme	arsenic	369:375	arg1	treatment					377:385	arsenic treatment	369:385	arsenic treatment	369:385	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	8	24	theme	endothermic	1091:1101	arg1	behavior					1103:1110	its endothermic behavior	1087:1110	its endothermic behavior	1087:1110	ΔG (>-11 kJ/mol), ΔH (42.48 kJ/mol), ΔS (177.6 JK-1 mol-1) and E a (59.16 kJ/mol) determined the feasibility of the process, its endothermic behavior and most importantly the chemical nature of the sorption accompanied by ion-exchange to some extent.
33901028	8	25	theme	chemical	1137:1144	arg1	nature					1146:1151	the chemical nature	1133:1151	the chemical nature of the sorption accompanied by ion-exchange to some extent	1133:1210	ΔG (>-11 kJ/mol), ΔH (42.48 kJ/mol), ΔS (177.6 JK-1 mol-1) and E a (59.16 kJ/mol) determined the feasibility of the process, its endothermic behavior and most importantly the chemical nature of the sorption accompanied by ion-exchange to some extent.
33901028	8	26	theme	JK-1	1009:1012	arg1	mol-1					1014:1018	177.6 JK-1 mol-1	1003:1018	177.6 JK-1 mol-1	1003:1018	ΔG (>-11 kJ/mol), ΔH (42.48 kJ/mol), ΔS (177.6 JK-1 mol-1) and E a (59.16 kJ/mol) determined the feasibility of the process, its endothermic behavior and most importantly the chemical nature of the sorption accompanied by ion-exchange to some extent.
33901028	8	26	theme	JK-1	1009:1012	arg1	ΔS					999:1000	ΔS	999:1000	ΔS (177.6 JK-1 mol-1)	999:1019	ΔG (>-11 kJ/mol), ΔH (42.48 kJ/mol), ΔS (177.6 JK-1 mol-1) and E a (59.16 kJ/mol) determined the feasibility of the process, its endothermic behavior and most importantly the chemical nature of the sorption accompanied by ion-exchange to some extent.
33901028	9	27	theme	chemisorption	1247:1259	arg1	pattern					1261:1267	a monolayer chemisorption pattern	1235:1267	a monolayer chemisorption pattern	1235:1267	The sorption followed a monolayer chemisorption pattern as determined by the Langmuir model (R2 = 0.973, R L = 0.081) with a qmax = 2.04 at 303 K.
33901028	8	28	theme	sorption	1160:1167	arg1	behavior					1103:1110	its endothermic behavior	1087:1110	its endothermic behavior	1087:1110	ΔG (>-11 kJ/mol), ΔH (42.48 kJ/mol), ΔS (177.6 JK-1 mol-1) and E a (59.16 kJ/mol) determined the feasibility of the process, its endothermic behavior and most importantly the chemical nature of the sorption accompanied by ion-exchange to some extent.
33901028	8	28	theme	sorption	1160:1167	arg1	nature					1146:1151	the chemical nature	1133:1151	the chemical nature of the sorption accompanied by ion-exchange to some extent	1133:1210	ΔG (>-11 kJ/mol), ΔH (42.48 kJ/mol), ΔS (177.6 JK-1 mol-1) and E a (59.16 kJ/mol) determined the feasibility of the process, its endothermic behavior and most importantly the chemical nature of the sorption accompanied by ion-exchange to some extent.
33901028	8	28	theme	sorption	1160:1167	arg1	feasibility					1059:1069	the feasibility	1055:1069	the feasibility of the process	1055:1084	ΔG (>-11 kJ/mol), ΔH (42.48 kJ/mol), ΔS (177.6 JK-1 mol-1) and E a (59.16 kJ/mol) determined the feasibility of the process, its endothermic behavior and most importantly the chemical nature of the sorption accompanied by ion-exchange to some extent.
33901028	8	29	theme	E	1025:1025	arg1	a					1027:1027	E a	1025:1027	E a (59.16 kJ/mol)	1025:1042	ΔG (>-11 kJ/mol), ΔH (42.48 kJ/mol), ΔS (177.6 JK-1 mol-1) and E a (59.16 kJ/mol) determined the feasibility of the process, its endothermic behavior and most importantly the chemical nature of the sorption accompanied by ion-exchange to some extent.
33901028	8	29	theme	E	1025:1025	arg1	kJ/mol					1036:1041	59.16 kJ/mol	1030:1041	59.16 kJ/mol	1030:1041	ΔG (>-11 kJ/mol), ΔH (42.48 kJ/mol), ΔS (177.6 JK-1 mol-1) and E a (59.16 kJ/mol) determined the feasibility of the process, its endothermic behavior and most importantly the chemical nature of the sorption accompanied by ion-exchange to some extent.
33901028	4	30	theme	material	555:562	arg1	preparation					564:574	material preparation	555:574	material preparation	555:574	All binding interactions during material preparation and arsenic sorption were exclusively characterized with FT-IR, XRD and other spectroscopic tools.
33901028	2	31	theme	starch	300:305	arg1	SICC					282:285	SICC	282:285	SICC	282:285	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	2	31	theme	starch	300:305	arg1	material					272:279	a hybrid material	263:279	a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay	263:341	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	10	32	from	binding	1364:1370	arg1	material					1390:1397	the material	1386:1397	the material	1386:1397	The binding of As(III) on the material was governed by a pseudo second order kinetic model.
33901028	10	33	theme	pseudo	1417:1422	arg1	model					1445:1449	a pseudo second order kinetic model	1415:1449	a pseudo second order kinetic model	1415:1449	The binding of As(III) on the material was governed by a pseudo second order kinetic model.
33901028	9	34	from	K	1357:1357	arg1	2.04					1345:1348	a qmax = 2.04	1336:1348	a qmax = 2.04 at 303 K	1336:1357	The sorption followed a monolayer chemisorption pattern as determined by the Langmuir model (R2 = 0.973, R L = 0.081) with a qmax = 2.04 at 303 K.
33901028	2	35	theme	aminated	291:298	arg1	starch					300:305	aminated starch	291:305	aminated starch	291:305	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	1	36	theme	arsenic	204:210	arg1	treatment					218:226	arsenic water treatment	204:226	arsenic water treatment	204:226	Materials which are chemically, energetically and operationally acceptable for arsenic water treatment are highly required.
33901028	0	37	theme	sorption	10:17	arg1	Nature					0:5	Nature	0:5	Nature of sorption of trivalent arsenic on novel iron oxyhydroxide	0:65	Nature of sorption of trivalent arsenic on novel iron oxyhydroxide stabilized starch/OMMT composite: A mechanistic approach.
33901028	5	38	theme	density	712:718	arg1	theory					731:736	density functional theory	712:736	density functional theory	712:736	A molecular modeling on the basis of density functional theory was carried out to verify the above findings.
33901028	9	39	dep	=	1309:1309	arg1	0.973					1311:1315	0.973	1311:1315	0.973	1311:1315	The sorption followed a monolayer chemisorption pattern as determined by the Langmuir model (R2 = 0.973, R L = 0.081) with a qmax = 2.04 at 303 K.
33901028	1	40	theme	water	212:216	arg1	treatment					218:226	arsenic water treatment	204:226	arsenic water treatment	204:226	Materials which are chemically, energetically and operationally acceptable for arsenic water treatment are highly required.
33901028	0	41	theme	arsenic	32:38	arg1	sorption					10:17	sorption	10:17	sorption of trivalent arsenic on novel iron oxyhydroxide	10:65	Nature of sorption of trivalent arsenic on novel iron oxyhydroxide stabilized starch/OMMT composite: A mechanistic approach.
33901028	5	42	theme	functional	720:729	arg1	theory					731:736	density functional theory	712:736	density functional theory	712:736	A molecular modeling on the basis of density functional theory was carried out to verify the above findings.
33901028	4	43	theme	spectroscopic	654:666	arg1	tools					668:672	other spectroscopic tools	648:672	other spectroscopic tools	648:672	All binding interactions during material preparation and arsenic sorption were exclusively characterized with FT-IR, XRD and other spectroscopic tools.
33901028	3	44	theme	arsenic	430:436	arg1	treatment					444:452	arsenic water treatment	430:452	arsenic water treatment which could reduce arsenic concentration far below detection limits	430:520	This new material was highly efficient in arsenic water treatment which could reduce arsenic concentration far below detection limits.
33901028	0	45	theme	trivalent	22:30	arg1	arsenic					32:38	trivalent arsenic	22:38	trivalent arsenic	22:38	Nature of sorption of trivalent arsenic on novel iron oxyhydroxide stabilized starch/OMMT composite: A mechanistic approach.
33901028	5	46	theme	theory	731:736	arg1	basis					703:707	the basis	699:707	the basis of density functional theory	699:736	A molecular modeling on the basis of density functional theory was carried out to verify the above findings.
33901028	0	47	from	oxyhydroxide	54:65	arg1	Nature					0:5	Nature	0:5	Nature of sorption of trivalent arsenic on novel iron oxyhydroxide	0:65	Nature of sorption of trivalent arsenic on novel iron oxyhydroxide stabilized starch/OMMT composite: A mechanistic approach.
33901028	9	48	theme	=	1309:1309	arg1	R2					1306:1307	R2	1306:1307	R2 = 0.973	1306:1315	The sorption followed a monolayer chemisorption pattern as determined by the Langmuir model (R2 = 0.973, R L = 0.081) with a qmax = 2.04 at 303 K.
33901028	3	49	theme	water	438:442	arg1	treatment					444:452	arsenic water treatment	430:452	arsenic water treatment which could reduce arsenic concentration far below detection limits	430:520	This new material was highly efficient in arsenic water treatment which could reduce arsenic concentration far below detection limits.
33901028	0	50	theme	novel	43:47	arg1	oxyhydroxide					54:65	novel iron oxyhydroxide	43:65	novel iron oxyhydroxide	43:65	Nature of sorption of trivalent arsenic on novel iron oxyhydroxide stabilized starch/OMMT composite: A mechanistic approach.
33901028	3	51	theme	arsenic	473:479	arg1	concentration					481:493	arsenic concentration	473:493	arsenic concentration	473:493	This new material was highly efficient in arsenic water treatment which could reduce arsenic concentration far below detection limits.
33901028	10	52	theme	kinetic	1437:1443	arg1	model					1445:1449	a pseudo second order kinetic model	1415:1449	a pseudo second order kinetic model	1415:1449	The binding of As(III) on the material was governed by a pseudo second order kinetic model.
33901028	9	53	theme	Langmuir	1290:1297	arg1	model					1299:1303	the Langmuir model	1286:1303	the Langmuir model (R2 = 0.973, R L = 0.081) with a qmax = 2.04 at 303 K	1286:1357	The sorption followed a monolayer chemisorption pattern as determined by the Langmuir model (R2 = 0.973, R L = 0.081) with a qmax = 2.04 at 303 K.
33901028	9	54	dep	=	1322:1322	arg1	R2					1306:1307	R2	1306:1307	R2 = 0.973	1306:1315	The sorption followed a monolayer chemisorption pattern as determined by the Langmuir model (R2 = 0.973, R L = 0.081) with a qmax = 2.04 at 303 K.
33901028	3	55	from	treatment	444:452	arg1	efficient					417:425	efficient	417:425	efficient	417:425	This new material was highly efficient in arsenic water treatment which could reduce arsenic concentration far below detection limits.
33901028	2	56	theme	iron	324:327	arg1	clay					338:341	OMMT clay	333:341	OMMT clay	333:341	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	2	56	theme	iron	324:327	arg1	oxyhydroxide					308:319	oxyhydroxide	308:319	oxyhydroxide of iron	308:327	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	2	56	theme	iron	324:327	arg1	starch					300:305	aminated starch	291:305	aminated starch	291:305	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	4	57	theme	binding	527:533	arg1	interactions					535:546	All binding interactions	523:546	All binding interactions during material preparation and arsenic sorption	523:595	All binding interactions during material preparation and arsenic sorption were exclusively characterized with FT-IR, XRD and other spectroscopic tools.
33901028	6	58	theme	ion	836:838	arg1	concentration					840:852	initial ion concentration	828:852	initial ion concentration	828:852	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	6	58	theme	ion	836:838	arg1	dose					806:809	material dose	797:809	material dose	797:809	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	2	59	theme	hybrid	265:270	arg1	SICC					282:285	SICC	282:285	SICC	282:285	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	2	59	theme	hybrid	265:270	arg1	material					272:279	a hybrid material	263:279	a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay	263:341	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	9	60	with	model	1299:1303	arg1	2.04					1345:1348	a qmax = 2.04	1336:1348	a qmax = 2.04 at 303 K	1336:1357	The sorption followed a monolayer chemisorption pattern as determined by the Langmuir model (R2 = 0.973, R L = 0.081) with a qmax = 2.04 at 303 K.
33901028	6	61	theme	initial	828:834	arg1	concentration					840:852	initial ion concentration	828:852	initial ion concentration	828:852	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	6	61	theme	initial	828:834	arg1	dose					806:809	material dose	797:809	material dose	797:809	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	2	62	theme	oxyhydroxide	308:319	arg1	SICC					282:285	SICC	282:285	SICC	282:285	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	2	62	theme	oxyhydroxide	308:319	arg1	material					272:279	a hybrid material	263:279	a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay	263:341	In this study a hybrid material (SICC) of aminated starch, oxyhydroxide of iron and OMMT clay has been demonstrated for arsenic treatment.
33901028	7	63	dep	viz	957:959	arg1	parameters					946:955	The thermodynamic parameters	928:955	The thermodynamic parameters	928:955	The thermodynamic parameters viz.
33901028	4	64	theme	other	648:652	arg1	tools					668:672	other spectroscopic tools	648:672	other spectroscopic tools	648:672	All binding interactions during material preparation and arsenic sorption were exclusively characterized with FT-IR, XRD and other spectroscopic tools.
33901028	6	65	from	Influence	784:792	arg1	extent					886:891	extent	886:891	extent of sorption	886:903	Influence of material dose, treatment time, initial ion concentration, varying temperatures, etc., on extent of sorption was studied in detail.
33901028	3	66	theme	detection	505:513	arg1	limits					515:520	detection limits	505:520	detection limits	505:520	This new material was highly efficient in arsenic water treatment which could reduce arsenic concentration far below detection limits.
33901028	5	67	from	modeling	687:694	arg1	basis					703:707	the basis	699:707	the basis of density functional theory	699:736	A molecular modeling on the basis of density functional theory was carried out to verify the above findings.
33901028	0	68	theme	iron	49:52	arg1	oxyhydroxide					54:65	novel iron oxyhydroxide	43:65	novel iron oxyhydroxide	43:65	Nature of sorption of trivalent arsenic on novel iron oxyhydroxide stabilized starch/OMMT composite: A mechanistic approach.
33901028	3	69	from	efficient	417:425	arg1	treatment					444:452	arsenic water treatment	430:452	arsenic water treatment which could reduce arsenic concentration far below detection limits	430:520	This new material was highly efficient in arsenic water treatment which could reduce arsenic concentration far below detection limits.
33901028	10	70	theme	order	1431:1435	arg1	model					1445:1449	a pseudo second order kinetic model	1415:1449	a pseudo second order kinetic model	1415:1449	The binding of As(III) on the material was governed by a pseudo second order kinetic model.
32720364	3	0	theme	CFU	806:808	arg1	BFD					810:812	106 CFU BFD	802:812	106 CFU BFD per g of feed compared to BMD and control birds	802:860	Significantly (P < 0·01) better growth performance and efficiency was observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to BMD and control birds.
32720364	5	1	theme	0·2	1378:1380	arg1	%					1381:1381	%	1381:1381	%	1381:1381	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	1	2	theme	production	247:256	arg1	performance					258:268	production performance	247:268	production performance	247:268	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	2	3	theme	g	667:667	arg1	feed					669:672	g feed	667:672	g feed	667:672	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	6	4	theme	health	1573:1578	arg1	indices					1580:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices	1471:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices	1471:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	5	5	theme	serum	1213:1217	arg1	glucose					1219:1225	lower serum glucose	1207:1225	lower serum glucose	1207:1225	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	2	6	theme	%	560:560	arg1	BFD					576:578	0·1% MOS + 107 CFU BFD	557:578	0·1% MOS + 107 CFU BFD per g feed	557:589	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	6	7	theme	CFU	1656:1658	arg1	BFD					1660:1662	106 CFU BFD	1652:1662	106 CFU BFD	1652:1662	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	3	8	theme	control	848:854	arg1	g					818:818	g	818:818	g of feed compared to BMD and control birds	818:860	Significantly (P < 0·01) better growth performance and efficiency was observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to BMD and control birds.
32720364	2	9	theme	g	624:624	arg1	feed					626:629	g feed	624:629	g feed	624:629	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	5	10	theme	CFU	1402:1404	arg1	BFD					1406:1408	106 CFU BFD	1398:1408	106 CFU BFD per g of feed compared to control or BMD supplemented birds	1398:1468	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	11	theme	HDL	1187:1189	arg1	cholesterol					1191:1201	serum HDL cholesterol	1181:1201	serum HDL cholesterol	1181:1201	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	2	12	theme	%	520:520	arg1	BFD					536:538	0·1% MOS + 106 CFU BFD	517:538	0·1% MOS + 106 CFU BFD per g feed	517:549	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	2	13	theme	0·2	640:642	arg1	BFD					659:661	0·2% MOS + 107 CFU BFD	640:661	0·2% MOS + 107 CFU BFD per g feed	640:672	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	6	14	theme	%	1642:1642	arg1	MOS					1644:1646	0·2% MOS	1639:1646	0·2% MOS	1639:1646	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	2	15	theme	0·2	597:599	arg1	%					600:600	%	600:600	%	600:600	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	2	16	theme	CFU	532:534	arg1	BFD					536:538	0·1% MOS + 106 CFU BFD	517:538	0·1% MOS + 106 CFU BFD per g feed	517:549	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	2	17	dep	T5	593:594	arg1	BFD					616:618	0·2% MOS + 106 CFU BFD	597:618	0·2% MOS + 106 CFU BFD per g feed	597:629	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	4	18	dep	Clostridium	1019:1029	arg1	perfringens					1031:1041	perfringens	1031:1041	perfringens	1031:1041	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	2	19	theme	bacitracin	477:486	arg1	disalicylate					498:509	bacitracin methylene disalicylate	477:509	positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate	423:509	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	4	20	theme	g	934:934	arg1	feed					936:939	g feed	934:939	g feed	934:939	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	0	21	theme	bifidum	85:91	arg1	effects					58:64	the beneficial effects	43:64	the beneficial effects of Bifidobacterium bifidum in broiler chicken	43:110	Dietary Mannan-oligosaccharides potentiate the beneficial effects of Bifidobacterium bifidum in broiler chicken.
32720364	4	22	dep	CFU	922:924	arg1	106					911:913	106	911:913	106	911:913	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	4	22	dep	CFU	922:924	arg1	107					918:920	107	918:920	107	918:920	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	1	23	theme	bifidum	176:182	arg1	effects					141:147	the effects	137:147	the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS)	137:221	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	1	23	theme	bifidum	176:182	arg1	synbiotic					229:237	synbiotic	229:237	synbiotic	229:237	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	2	24	theme	MOS + 106	602:610	arg1	BFD					616:618	0·2% MOS + 106 CFU BFD	597:618	0·2% MOS + 106 CFU BFD per g feed	597:629	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	0	25	theme	broiler	96:102	arg1	chicken					104:110	broiler chicken	96:110	broiler chicken	96:110	Dietary Mannan-oligosaccharides potentiate the beneficial effects of Bifidobacterium bifidum in broiler chicken.
32720364	2	26	dep	control-20 mg	432:444	arg1	disalicylate					498:509	bacitracin methylene disalicylate	477:509	positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate	423:509	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	2	26	dep	control-20 mg	432:444	arg1	BMD					472:474	BMD	472:474	positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate	423:509	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	2	26	dep	control-20 mg	432:444	arg1	diet					466:469	antibiotic BMD kg-1 diet	446:469	positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate	423:509	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	3	27	theme	better	701:706	arg1	performance					715:725	Significantly (P < 0·01) better growth performance	676:725	Significantly (P < 0·01) better growth performance	676:725	Significantly (P < 0·01) better growth performance and efficiency was observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to BMD and control birds.
32720364	6	28	theme	production	1478:1487	arg1	performance					1489:1499	Better production performance	1471:1499	Better production performance	1471:1499	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	5	29	theme	cardiac	1261:1267	arg1	ratio					1274:1278	cardiac risk ratio	1261:1278	cardiac risk ratio	1261:1278	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	1	30	theme	broiler	351:357	arg1	chicken					359:365	broiler chicken	351:365	broiler chicken	351:365	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	1	31	theme	dietary	152:158	arg1	bifidum					176:182	dietary Bifidobacterium bifidum	152:182	dietary Bifidobacterium bifidum (BFD)	152:188	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	1	31	theme	dietary	152:158	arg1	BFD					185:187	BFD	185:187	BFD	185:187	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	4	32	theme	plate	1002:1006	arg1	count					1008:1012	total plate count	996:1012	total plate count	996:1012	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	4	33	with	Supplementation	863:877	arg1	MOS					889:891	0·2% MOS	884:891	0·2% MOS along with either 106 or 107 CFU BFD per g feed	884:939	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	3	34	dep	better	701:706	arg1	P < 0·01					691:698	P < 0·01	691:698	P < 0·01	691:698	Significantly (P < 0·01) better growth performance and efficiency was observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to BMD and control birds.
32720364	2	35	theme	positive	423:430	arg1	T2					419:420	T2	419:420	T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate)	419:510	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	2	35	theme	positive	423:430	arg1	control-20 mg					432:444	positive control-20 mg	423:444	positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate	423:509	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	0	36	theme	Dietary	0:6	arg1	Mannan-oligosaccharides					8:30	Dietary Mannan-oligosaccharides	0:30	Dietary Mannan-oligosaccharides	0:30	Dietary Mannan-oligosaccharides potentiate the beneficial effects of Bifidobacterium bifidum in broiler chicken.
32720364	1	37	theme	gut	271:273	arg1	microbiology					275:286	gut microbiology	271:286	gut microbiology	271:286	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	3	38	located	observed	746:753	arg2	efficiency					731:740	efficiency	731:740	efficiency	731:740	Significantly (P < 0·01) better growth performance and efficiency was observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to BMD and control birds.
32720364	3	38	located	observed	746:753	arg2	performance					715:725	Significantly (P < 0·01) better growth performance	676:725	Significantly (P < 0·01) better growth performance	676:725	Significantly (P < 0·01) better growth performance and efficiency was observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to BMD and control birds.
32720364	3	38	located	observed	746:753	arg1	birds					758:762	birds	758:762	birds supplemented with 0·2% MOS	758:789	Significantly (P < 0·01) better growth performance and efficiency was observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to BMD and control birds.
32720364	5	39	dep	serum	1140:1144	arg1	pool					1175:1178	antioxidant enzyme pool	1156:1178	antioxidant enzyme pool	1156:1178	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	6	40	theme	antioxidant	1549:1559	arg1	profile					1561:1567	antioxidant profile	1549:1567	antioxidant profile	1549:1567	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	2	41	theme	g	584:584	arg1	feed					586:589	g feed	584:589	g feed	584:589	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	6	42	theme	biochemistry	1535:1546	arg1	indices					1580:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices	1471:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices	1471:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	2	43	theme	negative	400:407	arg1	T1					396:397	T1	396:397	T1 (negative control)	396:416	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	2	43	theme	negative	400:407	arg1	control					409:415	negative control	400:415	negative control	400:415	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	5	44	theme	feed	1419:1422	arg1	g					1414:1414	g	1414:1414	g of feed	1414:1422	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	0	45	theme	beneficial	47:56	arg1	effects					58:64	the beneficial effects	43:64	the beneficial effects of Bifidobacterium bifidum in broiler chicken	43:110	Dietary Mannan-oligosaccharides potentiate the beneficial effects of Bifidobacterium bifidum in broiler chicken.
32720364	2	46	theme	antibiotic	446:455	arg1	diet					466:469	antibiotic BMD kg-1 diet	446:469	positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate	423:509	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	5	47	theme	antioxidant	1156:1166	arg1	pool					1175:1178	antioxidant enzyme pool	1156:1178	antioxidant enzyme pool	1156:1178	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	1	48	theme	antioxidant	309:319	arg1	profile					321:327	antioxidant profile	309:327	antioxidant profile	309:327	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	3	49	theme	%	785:785	arg1	MOS					787:789	0·2% MOS	782:789	0·2% MOS	782:789	Significantly (P < 0·01) better growth performance and efficiency was observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to BMD and control birds.
32720364	4	50	theme	%	887:887	arg1	MOS					889:891	0·2% MOS	884:891	0·2% MOS along with either 106 or 107 CFU BFD per g feed	884:939	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	6	51	theme	microbial	1506:1514	arg1	composition					1516:1526	gut microbial composition	1502:1526	gut microbial composition	1502:1526	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	5	52	theme	atherogenic	1281:1291	arg1	coefficient					1293:1303	atherogenic coefficient	1281:1303	atherogenic coefficient	1281:1303	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	2	53	theme	CFU	655:657	arg1	BFD					659:661	0·2% MOS + 107 CFU BFD	640:661	0·2% MOS + 107 CFU BFD per g feed	640:672	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	6	54	theme	broiler	1605:1611	arg1	chicken					1613:1619	broiler chicken	1605:1619	broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed	1605:1676	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	4	55	theme	Clostridium	1019:1029	arg1	count					1043:1047	Clostridium perfringens count	1019:1047	Clostridium perfringens count	1019:1047	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	5	56	theme	higher	1133:1138	arg1	serum					1140:1144	serum	1140:1144	serum	1140:1144	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	57	theme	supplemented	1451:1462	arg1	birds					1464:1468	supplemented birds	1451:1468	supplemented birds	1451:1468	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	3	58	theme	106	802:804	arg1	CFU					806:808	CFU	806:808	CFU	806:808	Significantly (P < 0·01) better growth performance and efficiency was observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to BMD and control birds.
32720364	5	59	located	observed	1342:1349	arg2	glucose					1219:1225	lower serum glucose	1207:1225	lower serum glucose	1207:1225	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	59	located	observed	1342:1349	arg2	cholesterol					1191:1201	serum HDL cholesterol	1181:1201	serum HDL cholesterol	1181:1201	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	59	located	observed	1342:1349	arg2	liver					1150:1154	liver	1150:1154	liver	1150:1154	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	59	located	observed	1342:1349	arg1	birds					1354:1358	birds	1354:1358	birds supplemented with 0·2% MOS	1354:1385	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	59	located	observed	1342:1349	arg2	serum					1140:1144	serum	1140:1144	serum	1140:1144	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	3	60	theme	feed	823:826	arg1	g					818:818	g	818:818	g of feed compared to BMD and control birds	818:860	Significantly (P < 0·01) better growth performance and efficiency was observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to BMD and control birds.
32720364	5	61	theme	plasma	1330:1335	arg1	cholesterol					1191:1201	serum HDL cholesterol	1181:1201	serum HDL cholesterol	1181:1201	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	61	theme	plasma	1330:1335	arg1	index					1321:1325	atherogenic index	1309:1325	atherogenic index	1309:1325	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	61	theme	plasma	1330:1335	arg1	triglyceride					1228:1239	triglyceride	1228:1239	triglyceride	1228:1239	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	61	theme	plasma	1330:1335	arg1	liver					1150:1154	liver	1150:1154	liver	1150:1154	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	61	theme	plasma	1330:1335	arg1	ratio					1274:1278	cardiac risk ratio	1261:1278	cardiac risk ratio	1261:1278	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	61	theme	plasma	1330:1335	arg1	coefficient					1293:1303	atherogenic coefficient	1281:1303	atherogenic coefficient	1281:1303	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	61	theme	plasma	1330:1335	arg1	cholesterol					1248:1258	total cholesterol	1242:1258	total cholesterol	1242:1258	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	61	theme	plasma	1330:1335	arg1	glucose					1219:1225	lower serum glucose	1207:1225	lower serum glucose	1207:1225	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	61	theme	plasma	1330:1335	arg1	serum					1140:1144	serum	1140:1144	serum	1140:1144	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	5	62	theme	lower	1207:1211	arg1	glucose					1219:1225	lower serum glucose	1207:1225	lower serum glucose	1207:1225	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	2	63	dep	T3	513:514	arg1	BFD					536:538	0·1% MOS + 106 CFU BFD	517:538	0·1% MOS + 106 CFU BFD per g feed	517:549	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	2	64	theme	g	544:544	arg1	feed					546:549	g feed	544:549	g feed	544:549	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	4	65	theme	Lactobacillus	1067:1079	arg1	count					1101:1105	the Lactobacillus and Bifidobacterium count	1063:1105	count	1101:1105	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	2	66	theme	0·1	557:559	arg1	BFD					576:578	0·1% MOS + 107 CFU BFD	557:578	0·1% MOS + 107 CFU BFD per g feed	557:589	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	6	67	theme	106	1652:1654	arg1	CFU					1656:1658	CFU	1656:1658	CFU	1656:1658	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	5	68	theme	106	1398:1400	arg1	CFU					1402:1404	CFU	1402:1404	CFU	1402:1404	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	4	69	theme	Bifidobacterium	1085:1099	arg1	count					1101:1105	the Lactobacillus and Bifidobacterium count	1063:1105	count	1101:1105	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	5	70	theme	serum	1181:1185	arg1	cholesterol					1191:1201	serum HDL cholesterol	1181:1201	serum HDL cholesterol	1181:1201	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	1	71	theme	mannan-oligosaccharide	194:215	arg1	effects					141:147	the effects	137:147	the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS)	137:221	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	1	71	theme	mannan-oligosaccharide	194:215	arg1	synbiotic					229:237	synbiotic	229:237	synbiotic	229:237	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	2	72	dep	T4	553:554	arg1	BFD					576:578	0·1% MOS + 107 CFU BFD	557:578	0·1% MOS + 107 CFU BFD per g feed	557:589	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	2	73	theme	%	643:643	arg1	BFD					659:661	0·2% MOS + 107 CFU BFD	640:661	0·2% MOS + 107 CFU BFD per g feed	640:672	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	2	74	theme	0·1	517:519	arg1	BFD					536:538	0·1% MOS + 106 CFU BFD	517:538	0·1% MOS + 106 CFU BFD per g feed	517:549	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	6	75	theme	0·2	1639:1641	arg1	%					1642:1642	%	1642:1642	%	1642:1642	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	5	76	theme	%	1381:1381	arg1	MOS					1383:1385	0·2% MOS	1378:1385	0·2% MOS	1378:1385	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	2	77	theme	%	600:600	arg1	BFD					616:618	0·2% MOS + 106 CFU BFD	597:618	0·2% MOS + 106 CFU BFD per g feed	597:629	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	1	78	dep	performance	258:268	arg1	the					243:245	the	243:245	the	243:245	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	5	79	dep	control	1436:1442	arg1	birds					1464:1468	supplemented birds	1451:1468	supplemented birds	1451:1468	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	4	80	theme	gut	964:966	arg1	coliform					968:975	the gut coliform	960:975	the gut coliform	960:975	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	4	80	theme	gut	964:966	arg1	P < 0·01					950:957	P < 0·01	950:957	P < 0·01	950:957	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	6	81	theme	feed	1673:1676	arg1	g					1668:1668	g	1668:1668	g of feed	1668:1676	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	4	82	dep	BFD	926:928	arg1	CFU					922:924	CFU	922:924	CFU	922:924	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	1	83	theme	Bifidobacterium	160:174	arg1	bifidum					176:182	dietary Bifidobacterium bifidum	152:182	dietary Bifidobacterium bifidum (BFD)	152:188	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	1	83	theme	Bifidobacterium	160:174	arg1	BFD					185:187	BFD	185:187	BFD	185:187	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	6	84	theme	gut	1502:1504	arg1	composition					1516:1526	gut microbial composition	1502:1526	gut microbial composition	1502:1526	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	2	85	theme	CFU	612:614	arg1	BFD					616:618	0·2% MOS + 106 CFU BFD	597:618	0·2% MOS + 106 CFU BFD per g feed	597:629	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	1	86	theme	health	333:338	arg1	indices					340:346	health indices	333:346	health indices	333:346	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	6	87	theme	performance	1489:1499	arg1	indices					1580:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices	1471:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices	1471:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	4	88	theme	total	996:1000	arg1	count					1008:1012	total plate count	996:1012	total plate count	996:1012	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	3	89	theme	growth	708:713	arg1	performance					715:725	Significantly (P < 0·01) better growth performance	676:725	Significantly (P < 0·01) better growth performance	676:725	Significantly (P < 0·01) better growth performance and efficiency was observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to BMD and control birds.
32720364	6	90	theme	Better	1471:1476	arg1	performance					1489:1499	Better production performance	1471:1499	Better production performance	1471:1499	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	5	91	theme	risk	1269:1272	arg1	ratio					1274:1278	cardiac risk ratio	1261:1278	cardiac risk ratio	1261:1278	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	2	92	theme	CFU	572:574	arg1	BFD					576:578	0·1% MOS + 107 CFU BFD	557:578	0·1% MOS + 107 CFU BFD per g feed	557:589	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	1	93	theme	chicken	359:365	arg1	indices					340:346	health indices	333:346	health indices	333:346	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	1	93	theme	chicken	359:365	arg1	performance					258:268	production performance	247:268	production performance	247:268	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	1	93	theme	chicken	359:365	arg1	microbiology					275:286	gut microbiology	271:286	gut microbiology	271:286	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	1	93	theme	chicken	359:365	arg1	biochemistry					295:306	serum biochemistry	289:306	serum biochemistry	289:306	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	1	93	theme	chicken	359:365	arg1	profile					321:327	antioxidant profile	309:327	antioxidant profile	309:327	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	2	94	theme	methylene	488:496	arg1	disalicylate					498:509	bacitracin methylene disalicylate	477:509	positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate	423:509	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	0	95	from	effects	58:64	arg1	chicken					104:110	broiler chicken	96:110	broiler chicken	96:110	Dietary Mannan-oligosaccharides potentiate the beneficial effects of Bifidobacterium bifidum in broiler chicken.
32720364	6	96	theme	profile	1561:1567	arg1	indices					1580:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices	1471:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices	1471:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	5	97	theme	total	1242:1246	arg1	cholesterol					1248:1258	total cholesterol	1242:1258	total cholesterol	1242:1258	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	2	98	theme	dietary	372:378	arg1	treatments					380:389	Six dietary treatments	368:389	Six dietary treatments	368:389	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	3	99	theme	0·2	782:784	arg1	%					785:785	%	785:785	%	785:785	Significantly (P < 0·01) better growth performance and efficiency was observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to BMD and control birds.
32720364	5	100	theme	atherogenic	1309:1319	arg1	index					1321:1325	atherogenic index	1309:1325	atherogenic index	1309:1325	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	1	101	theme	serum	289:293	arg1	biochemistry					295:306	serum biochemistry	289:306	serum biochemistry	289:306	This study investigated the effects of dietary Bifidobacterium bifidum (BFD) and mannan-oligosaccharide (MOS), as a synbiotic, on the production performance, gut microbiology, serum biochemistry, antioxidant profile and health indices of broiler chicken.
32720364	5	102	dep	higher	1133:1138	arg1	P < 0·01					1123:1130	P < 0·01	1123:1130	P < 0·01	1123:1130	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	2	103	theme	BMD kg-1	457:464	arg1	diet					466:469	antibiotic BMD kg-1 diet	446:469	positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate	423:509	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	6	104	theme	serum	1529:1533	arg1	biochemistry					1535:1546	serum biochemistry	1529:1546	serum biochemistry	1529:1546	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	0	105	theme	Bifidobacterium	69:83	arg1	bifidum					85:91	Bifidobacterium bifidum	69:91	Bifidobacterium bifidum	69:91	Dietary Mannan-oligosaccharides potentiate the beneficial effects of Bifidobacterium bifidum in broiler chicken.
32720364	2	106	dep	T6	636:637	arg1	BFD					659:661	0·2% MOS + 107 CFU BFD	640:661	0·2% MOS + 107 CFU BFD per g feed	640:672	Six dietary treatments were T1 (negative control), T2 (positive control-20 mg antibiotic BMD kg-1 diet; BMD: bacitracin methylene disalicylate), T3 (0·1% MOS + 106 CFU BFD per g feed), T4 (0·1% MOS + 107 CFU BFD per g feed), T5 (0·2% MOS + 106 CFU BFD per g feed) and T6 (0·2% MOS + 107 CFU BFD per g feed).
32720364	6	107	theme	composition	1516:1526	arg1	indices					1580:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices	1471:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices	1471:1586	Better production performance, gut microbial composition, serum biochemistry, antioxidant profile and health indices were depicted by broiler chicken supplemented with 0·2% MOS and 106 CFU BFD per g of feed.
32720364	5	108	theme	enzyme	1168:1173	arg1	pool					1175:1178	antioxidant enzyme pool	1156:1178	antioxidant enzyme pool	1156:1178	Significantly (P < 0·01) higher serum and liver antioxidant enzyme pool, serum HDL cholesterol and lower serum glucose, triglyceride, total cholesterol, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma were observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to control or BMD supplemented birds.
32720364	4	109	theme	0·2	884:886	arg1	MOS					889:891	0·2% MOS	884:891	0·2% MOS along with either 106 or 107 CFU BFD per g feed	884:939	Supplementation with 0·2% MOS along with either 106 or 107 CFU BFD per g feed reduced (P < 0·01) the gut coliform, Escherichia coli, total plate count, and Clostridium perfringens count and increased the Lactobacillus and Bifidobacterium count.
32720364	3	110	dep	feed	823:826	arg1	birds					856:860	birds	856:860	birds	856:860	Significantly (P < 0·01) better growth performance and efficiency was observed in birds supplemented with 0·2% MOS along with 106 CFU BFD per g of feed compared to BMD and control birds.
34416333	6	0	theme	entire	1159:1164	arg1	period					1180:1185	the entire 7-day testing period	1155:1185	the entire 7-day testing period	1155:1185	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	4	1	theme	NPs-SAIB-PLGA	834:846	arg1	rate					822:825	the drug release rate	805:825	the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS)	805:876	The results showed that different solvent and PLGA contents could affect the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS).
34416333	3	2	theme	Assisted	692:699	arg1	ART					726:728	ART	726:728	ART	726:728	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	3	2	theme	Assisted	692:699	arg1	Technology					714:723	Assisted Reproductive Technology	692:723	Assisted Reproductive Technology (ART)	692:729	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	8	3	theme	PRG	1456:1458	arg1	NPs					1460:1462	PRG NPs	1456:1462	PRG NPs	1456:1462	The results demonstrate that PRG NPs could successfully achieve both reduced administered dosage and burst release, and therefore that PSPIDS is a promising long-acting composite system for hydrophobic drugs.
34416333	6	4	theme	such	1073:1076	arg1	PSPIDS					1078:1083	such PSPIDS	1073:1083	such PSPIDS	1073:1083	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	4	5	theme	PRG	830:832	arg1	NPs-SAIB-PLGA					834:846	PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS)	830:876	PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS)	830:876	The results showed that different solvent and PLGA contents could affect the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS).
34416333	2	6	theme	grand	338:342	arg1	challenge					344:352	a grand challenge	336:352	a grand challenge to simultaneously achieve low-dose drugs, stable and prolonged drug release, and long-term retention circumventing uptake by macrophages	336:489	However, it is currently a grand challenge to simultaneously achieve low-dose drugs, stable and prolonged drug release, and long-term retention circumventing uptake by macrophages.
34416333	2	6	theme	grand	338:342	arg1	it					320:321	it	320:321	it	320:321	However, it is currently a grand challenge to simultaneously achieve low-dose drugs, stable and prolonged drug release, and long-term retention circumventing uptake by macrophages.
34416333	6	7	theme	commercial	1205:1214	arg1	1914.5 ± 180.7 μg/L·h					1268:1288	1914.5 ± 180.7 μg/L·h	1268:1288	1914.5 ± 180.7 μg/L·h	1268:1288	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	6	7	theme	commercial	1205:1214	arg1	solution					1258:1265	the commercial multiple-day-dosing intramuscular PRG-oil solution	1201:1265	the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h)	1201:1289	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	0	8	theme	drug	108:111	arg1	release					113:119	sustained drug release	98:119	sustained drug release	98:119	Novel injectable progesterone-loaded nanoparticles embedded in SAIB-PLGA in situ depot system for sustained drug release.
34416333	3	9	theme	long	669:672	arg1	treatment					679:687	the long term treatment	665:687	the long term treatment of Assisted Reproductive Technology (ART)	665:729	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	4	10	theme	depot	856:860	arg1	PSPIDS					870:875	PSPIDS	870:875	PSPIDS	870:875	The results showed that different solvent and PLGA contents could affect the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS).
34416333	4	10	theme	depot	856:860	arg1	system					862:867	in-situ depot system	848:867	PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS)	830:876	The results showed that different solvent and PLGA contents could affect the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS).
34416333	6	11	theme	drug	1099:1102	arg1	concentration					1104:1116	higher drug concentration	1092:1116	higher drug concentration	1092:1116	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	5	12	theme	PLGA	933:936	arg1	addition					918:925	the addition	914:925	the addition of 8% PLGA to the depot	914:949	When DMSO was used as solvent with the addition of 8% PLGA to the depot, PSPIDS could achieve a constant drug release with no burst for 2 weeks in vitro.
34416333	1	13	theme	sustained-release	247:263	arg1	system					279:284	a sustained-release drug delivery system	245:284	a sustained-release drug delivery system for localized treatment	245:308	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	1	13	theme	sustained-release	247:263	arg1	interest					208:215	considerable interest	195:215	considerable interest in the medical community	195:240	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	0	14	theme	sustained	98:106	arg1	release					113:119	sustained drug release	98:119	sustained drug release	98:119	Novel injectable progesterone-loaded nanoparticles embedded in SAIB-PLGA in situ depot system for sustained drug release.
34416333	3	15	theme	Reproductive	701:712	arg1	ART					726:728	ART	726:728	ART	726:728	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	3	15	theme	Reproductive	701:712	arg1	Technology					714:723	Assisted Reproductive Technology	692:723	Assisted Reproductive Technology (ART)	692:729	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	4	16	theme	in-situ	848:854	arg1	PSPIDS					870:875	PSPIDS	870:875	PSPIDS	870:875	The results showed that different solvent and PLGA contents could affect the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS).
34416333	4	16	theme	in-situ	848:854	arg1	system					862:867	in-situ depot system	848:867	PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS)	830:876	The results showed that different solvent and PLGA contents could affect the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS).
34416333	6	17	theme	higher	1092:1097	arg1	concentration					1104:1116	higher drug concentration	1092:1116	higher drug concentration	1092:1116	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	1	18	theme	drug	265:268	arg1	system					279:284	a sustained-release drug delivery system	245:284	a sustained-release drug delivery system for localized treatment	245:308	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	1	18	theme	drug	265:268	arg1	interest					208:215	considerable interest	195:215	considerable interest in the medical community	195:240	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	3	19	theme	Technology	714:723	arg1	treatment					679:687	the long term treatment	665:687	the long term treatment of Assisted Reproductive Technology (ART)	665:729	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	4	20	theme	release	814:820	arg1	rate					822:825	the drug release rate	805:825	the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS)	805:876	The results showed that different solvent and PLGA contents could affect the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS).
34416333	3	21	theme	in-situ	530:536	arg1	system					544:549	a solvent-exchange in-situ depot system	511:549	a solvent-exchange in-situ depot system	511:549	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	4	22	theme	drug	809:812	arg1	rate					822:825	the drug release rate	805:825	the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS)	805:876	The results showed that different solvent and PLGA contents could affect the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS).
34416333	3	23	theme	depot	538:542	arg1	system					544:549	a solvent-exchange in-situ depot system	511:549	a solvent-exchange in-situ depot system	511:549	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	4	24	theme	different	756:764	arg1	solvent					766:772	different solvent and PLGA contents	756:790	solvent	766:772	The results showed that different solvent and PLGA contents could affect the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS).
34416333	0	25	theme	injectable	6:15	arg1	progesterone-loaded					17:35	Novel injectable progesterone-loaded	0:35	Novel injectable progesterone-loaded	0:35	Novel injectable progesterone-loaded nanoparticles embedded in SAIB-PLGA in situ depot system for sustained drug release.
34416333	0	26	from	embedded	51:58	arg1	system					87:92	SAIB-PLGA in situ depot system	63:92	SAIB-PLGA in situ depot system for sustained drug release	63:119	Novel injectable progesterone-loaded nanoparticles embedded in SAIB-PLGA in situ depot system for sustained drug release.
34416333	6	27	theme	7-day	1166:1170	arg1	period					1180:1185	the entire 7-day testing period	1155:1185	the entire 7-day testing period	1155:1185	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	6	28	theme	multiple-day-dosing	1216:1234	arg1	1914.5 ± 180.7 μg/L·h					1268:1288	1914.5 ± 180.7 μg/L·h	1268:1288	1914.5 ± 180.7 μg/L·h	1268:1288	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	6	28	theme	multiple-day-dosing	1216:1234	arg1	solution					1258:1265	the commercial multiple-day-dosing intramuscular PRG-oil solution	1201:1265	the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h)	1201:1289	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	7	29	theme	dose	1391:1394	arg1	dose					1347:1350	a dose	1345:1350	a dose	1345:1350	Importantly, PSPIDS could be administered at a dose of 3.65 mg/kg, which was one fourth of dose required for PRG-oil solution.
34416333	7	29	theme	dose	1391:1394	arg1	fourth					1381:1386	fourth	1381:1386	fourth	1381:1386	Importantly, PSPIDS could be administered at a dose of 3.65 mg/kg, which was one fourth of dose required for PRG-oil solution.
34416333	2	30	theme	low-dose	380:387	arg1	drugs					389:393	low-dose drugs	380:393	low-dose drugs	380:393	However, it is currently a grand challenge to simultaneously achieve low-dose drugs, stable and prolonged drug release, and long-term retention circumventing uptake by macrophages.
34416333	0	31	theme	Novel	0:4	arg1	progesterone-loaded					17:35	Novel injectable progesterone-loaded	0:35	Novel injectable progesterone-loaded	0:35	Novel injectable progesterone-loaded nanoparticles embedded in SAIB-PLGA in situ depot system for sustained drug release.
34416333	1	32	theme	delivery	270:277	arg1	system					279:284	a sustained-release drug delivery system	245:284	a sustained-release drug delivery system for localized treatment	245:308	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	1	32	theme	delivery	270:277	arg1	interest					208:215	considerable interest	195:215	considerable interest in the medical community	195:240	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	5	33	theme	drug	984:987	arg1	release					989:995	a constant drug release	973:995	a constant drug release	973:995	When DMSO was used as solvent with the addition of 8% PLGA to the depot, PSPIDS could achieve a constant drug release with no burst for 2 weeks in vitro.
34416333	5	34	used	used	893:896	arg2	DMSO					884:887	DMSO	884:887	DMSO	884:887	When DMSO was used as solvent with the addition of 8% PLGA to the depot, PSPIDS could achieve a constant drug release with no burst for 2 weeks in vitro.
34416333	5	34	used	used	893:896	arg2	solvent					901:907	solvent	901:907	solvent	901:907	When DMSO was used as solvent with the addition of 8% PLGA to the depot, PSPIDS could achieve a constant drug release with no burst for 2 weeks in vitro.
34416333	6	35	theme	intramuscular	1048:1060	arg1	injection					1062:1070	a single intramuscular injection	1039:1070	a single intramuscular injection	1039:1070	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	3	36	theme	PLGA	594:597	arg1	NPs					599:601	progesterone (PRG) loaded PLGA NPs	568:601	progesterone (PRG) loaded PLGA NPs	568:601	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	2	37	theme	drug	417:420	arg1	release					422:428	stable and prolonged drug release	396:428	stable and prolonged drug release	396:428	However, it is currently a grand challenge to simultaneously achieve low-dose drugs, stable and prolonged drug release, and long-term retention circumventing uptake by macrophages.
34416333	8	38	theme	reduced	1496:1502	arg1	dosage					1517:1522	reduced administered dosage	1496:1522	reduced administered dosage	1496:1522	The results demonstrate that PRG NPs could successfully achieve both reduced administered dosage and burst release, and therefore that PSPIDS is a promising long-acting composite system for hydrophobic drugs.
34416333	7	39	theme	3.65 mg/kg	1355:1364	arg1	dose					1347:1350	a dose	1345:1350	a dose	1345:1350	Importantly, PSPIDS could be administered at a dose of 3.65 mg/kg, which was one fourth of dose required for PRG-oil solution.
34416333	7	39	theme	3.65 mg/kg	1355:1364	arg1	fourth					1381:1386	fourth	1381:1386	fourth	1381:1386	Importantly, PSPIDS could be administered at a dose of 3.65 mg/kg, which was one fourth of dose required for PRG-oil solution.
34416333	3	40	theme	progesterone	568:579	arg1	NPs					599:601	progesterone (PRG) loaded PLGA NPs	568:601	progesterone (PRG) loaded PLGA NPs	568:601	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	2	41	theme	prolonged	407:415	arg1	release					422:428	stable and prolonged drug release	396:428	stable and prolonged drug release	396:428	However, it is currently a grand challenge to simultaneously achieve low-dose drugs, stable and prolonged drug release, and long-term retention circumventing uptake by macrophages.
34416333	1	42	theme	localized	290:298	arg1	treatment					300:308	localized treatment	290:308	localized treatment	290:308	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	0	43	from	system	87:92	arg1	embedded					51:58	embedded	51:58	embedded	51:58	Novel injectable progesterone-loaded nanoparticles embedded in SAIB-PLGA in situ depot system for sustained drug release.
34416333	0	44	dep	in	73:74	arg1	situ					76:79	situ	76:79	situ	76:79	Novel injectable progesterone-loaded nanoparticles embedded in SAIB-PLGA in situ depot system for sustained drug release.
34416333	1	45	theme	considerable	195:206	arg1	system					279:284	a sustained-release drug delivery system	245:284	a sustained-release drug delivery system for localized treatment	245:308	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	1	45	theme	considerable	195:206	arg1	interest					208:215	considerable interest	195:215	considerable interest in the medical community	195:240	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	6	46	theme	testing	1172:1178	arg1	period					1180:1185	the entire 7-day testing period	1155:1185	the entire 7-day testing period	1155:1185	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	2	47	theme	stable	396:401	arg1	release					422:428	stable and prolonged drug release	396:428	stable and prolonged drug release	396:428	However, it is currently a grand challenge to simultaneously achieve low-dose drugs, stable and prolonged drug release, and long-term retention circumventing uptake by macrophages.
34416333	0	48	theme	in	73:74	arg1	system					87:92	SAIB-PLGA in situ depot system	63:92	SAIB-PLGA in situ depot system for sustained drug release	63:119	Novel injectable progesterone-loaded nanoparticles embedded in SAIB-PLGA in situ depot system for sustained drug release.
34416333	8	49	theme	administered	1504:1515	arg1	dosage					1517:1522	reduced administered dosage	1496:1522	reduced administered dosage	1496:1522	The results demonstrate that PRG NPs could successfully achieve both reduced administered dosage and burst release, and therefore that PSPIDS is a promising long-acting composite system for hydrophobic drugs.
34416333	1	50	from	interest	208:215	arg1	community					232:240	the medical community	220:240	the medical community	220:240	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	1	51	theme	Poly	122:125	arg1	NPs					175:177	NPs	175:177	NPs	175:177	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	1	51	theme	Poly	122:125	arg1	nanoparticles					160:172	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles	122:172	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs)	122:178	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	0	52	theme	SAIB-PLGA	63:71	arg1	system					87:92	SAIB-PLGA in situ depot system	63:92	SAIB-PLGA in situ depot system for sustained drug release	63:119	Novel injectable progesterone-loaded nanoparticles embedded in SAIB-PLGA in situ depot system for sustained drug release.
34416333	8	53	theme	burst	1528:1532	arg1	release					1534:1540	burst release	1528:1540	burst release	1528:1540	The results demonstrate that PRG NPs could successfully achieve both reduced administered dosage and burst release, and therefore that PSPIDS is a promising long-acting composite system for hydrophobic drugs.
34416333	6	54	theme	PRG-oil	1250:1256	arg1	1914.5 ± 180.7 μg/L·h					1268:1288	1914.5 ± 180.7 μg/L·h	1268:1288	1914.5 ± 180.7 μg/L·h	1268:1288	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	6	54	theme	PRG-oil	1250:1256	arg1	solution					1258:1265	the commercial multiple-day-dosing intramuscular PRG-oil solution	1201:1265	the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h)	1201:1289	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	3	55	theme	loaded	587:592	arg1	NPs					599:601	progesterone (PRG) loaded PLGA NPs	568:601	progesterone (PRG) loaded PLGA NPs	568:601	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	8	56	theme	long-acting	1584:1594	arg1	PSPIDS					1562:1567	PSPIDS	1562:1567	PSPIDS	1562:1567	The results demonstrate that PRG NPs could successfully achieve both reduced administered dosage and burst release, and therefore that PSPIDS is a promising long-acting composite system for hydrophobic drugs.
34416333	8	56	theme	long-acting	1584:1594	arg1	system					1606:1611	a promising long-acting composite system	1572:1611	a promising long-acting composite system for hydrophobic drugs	1572:1633	The results demonstrate that PRG NPs could successfully achieve both reduced administered dosage and burst release, and therefore that PSPIDS is a promising long-acting composite system for hydrophobic drugs.
34416333	6	57	theme	intramuscular	1236:1248	arg1	1914.5 ± 180.7 μg/L·h					1268:1288	1914.5 ± 180.7 μg/L·h	1268:1288	1914.5 ± 180.7 μg/L·h	1268:1288	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	6	57	theme	intramuscular	1236:1248	arg1	solution					1258:1265	the commercial multiple-day-dosing intramuscular PRG-oil solution	1201:1265	the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h)	1201:1289	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	5	58	theme	%	931:931	arg1	PLGA					933:936	8% PLGA	930:936	8% PLGA	930:936	When DMSO was used as solvent with the addition of 8% PLGA to the depot, PSPIDS could achieve a constant drug release with no burst for 2 weeks in vitro.
34416333	3	59	theme	sucrose	610:616	arg1	SAIB					639:642	SAIB	639:642	SAIB	639:642	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	3	59	theme	sucrose	610:616	arg1	isobutyrate					626:636	a sucrose acetate isobutyrate	608:636	a sucrose acetate isobutyrate (SAIB)	608:643	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	1	60	theme	lactic-co-glycolic	128:145	arg1	Poly					122:125	Poly	122:125	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs)	122:178	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	1	60	theme	lactic-co-glycolic	128:145	arg1	acid					147:150	lactic-co-glycolic acid	128:150	lactic-co-glycolic acid	128:150	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	8	61	theme	promising	1574:1582	arg1	PSPIDS					1562:1567	PSPIDS	1562:1567	PSPIDS	1562:1567	The results demonstrate that PRG NPs could successfully achieve both reduced administered dosage and burst release, and therefore that PSPIDS is a promising long-acting composite system for hydrophobic drugs.
34416333	8	61	theme	promising	1574:1582	arg1	system					1606:1611	a promising long-acting composite system	1572:1611	a promising long-acting composite system for hydrophobic drugs	1572:1633	The results demonstrate that PRG NPs could successfully achieve both reduced administered dosage and burst release, and therefore that PSPIDS is a promising long-acting composite system for hydrophobic drugs.
34416333	7	62	theme	PRG-oil	1409:1415	arg1	solution					1417:1424	PRG-oil solution	1409:1424	PRG-oil solution	1409:1424	Importantly, PSPIDS could be administered at a dose of 3.65 mg/kg, which was one fourth of dose required for PRG-oil solution.
34416333	5	63	theme	8	930:930	arg1	%					931:931	%	931:931	%	931:931	When DMSO was used as solvent with the addition of 8% PLGA to the depot, PSPIDS could achieve a constant drug release with no burst for 2 weeks in vitro.
34416333	5	64	theme	constant	975:982	arg1	release					989:995	a constant drug release	973:995	a constant drug release	973:995	When DMSO was used as solvent with the addition of 8% PLGA to the depot, PSPIDS could achieve a constant drug release with no burst for 2 weeks in vitro.
34416333	3	65	theme	acetate	618:624	arg1	SAIB					639:642	SAIB	639:642	SAIB	639:642	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	3	65	theme	acetate	618:624	arg1	isobutyrate					626:636	a sucrose acetate isobutyrate	608:636	a sucrose acetate isobutyrate (SAIB)	608:643	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	3	66	theme	solvent-exchange	513:528	arg1	system					544:549	a solvent-exchange in-situ depot system	511:549	a solvent-exchange in-situ depot system	511:549	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	6	67	theme	single	1041:1046	arg1	injection					1062:1070	a single intramuscular injection	1039:1070	a single intramuscular injection	1039:1070	After a single intramuscular injection, such PSPIDS showed higher drug concentration and AUC (6773.0 ± 348.8 μg/L·h) over the entire 7-day testing period compared with the commercial multiple-day-dosing intramuscular PRG-oil solution (1914.5 ± 180.7 μg/L·h) in vivo.
34416333	0	68	theme	depot	81:85	arg1	system					87:92	SAIB-PLGA in situ depot system	63:92	SAIB-PLGA in situ depot system for sustained drug release	63:119	Novel injectable progesterone-loaded nanoparticles embedded in SAIB-PLGA in situ depot system for sustained drug release.
34416333	3	69	theme	PLGA	649:652	arg1	matrix					654:659	PLGA matrix	649:659	PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART)	649:729	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	4	70	theme	PLGA	778:781	arg1	contents					783:790	different solvent and PLGA contents	756:790	contents	783:790	The results showed that different solvent and PLGA contents could affect the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS).
34416333	8	71	theme	composite	1596:1604	arg1	PSPIDS					1562:1567	PSPIDS	1562:1567	PSPIDS	1562:1567	The results demonstrate that PRG NPs could successfully achieve both reduced administered dosage and burst release, and therefore that PSPIDS is a promising long-acting composite system for hydrophobic drugs.
34416333	8	71	theme	composite	1596:1604	arg1	system					1606:1611	a promising long-acting composite system	1572:1611	a promising long-acting composite system for hydrophobic drugs	1572:1633	The results demonstrate that PRG NPs could successfully achieve both reduced administered dosage and burst release, and therefore that PSPIDS is a promising long-acting composite system for hydrophobic drugs.
34416333	1	72	theme	medical	224:230	arg1	community					232:240	the medical community	220:240	the medical community	220:240	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have attracted considerable interest in the medical community as a sustained-release drug delivery system for localized treatment.
34416333	4	73	dep	NPs-SAIB-PLGA	834:846	arg1	PSPIDS					870:875	PSPIDS	870:875	PSPIDS	870:875	The results showed that different solvent and PLGA contents could affect the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS).
34416333	4	73	dep	NPs-SAIB-PLGA	834:846	arg1	system					862:867	in-situ depot system	848:867	PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS)	830:876	The results showed that different solvent and PLGA contents could affect the drug release rate of PRG NPs-SAIB-PLGA in-situ depot system (PSPIDS).
34416333	3	74	theme	term	674:677	arg1	treatment					679:687	the long term treatment	665:687	the long term treatment of Assisted Reproductive Technology (ART)	665:729	Here, we construct a solvent-exchange in-situ depot system by incorporating progesterone (PRG) loaded PLGA NPs into a sucrose acetate isobutyrate (SAIB) and PLGA matrix for the long term treatment of Assisted Reproductive Technology (ART).
34416333	2	75	theme	long-term	435:443	arg1	retention					445:453	long-term retention	435:453	long-term retention circumventing uptake by macrophages	435:489	However, it is currently a grand challenge to simultaneously achieve low-dose drugs, stable and prolonged drug release, and long-term retention circumventing uptake by macrophages.
34416333	8	76	theme	hydrophobic	1617:1627	arg1	drugs					1629:1633	hydrophobic drugs	1617:1633	hydrophobic drugs	1617:1633	The results demonstrate that PRG NPs could successfully achieve both reduced administered dosage and burst release, and therefore that PSPIDS is a promising long-acting composite system for hydrophobic drugs.
32446452	3	0	theme	inhibitory	673:682	arg1	effect					684:689	little inhibitory effect	666:689	little inhibitory effect	666:689	The results showed that SA in low concentrations (≤400 mg/L) had little inhibitory effect on the phosphorus recovery rate.
32446452	2	1	theme	synthetic	579:587	arg1	wastewater					589:598	synthetic wastewater	579:598	synthetic wastewater	579:598	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	6	2	theme	inhibitory	991:1000	arg1	effect					1002:1007	the inhibitory effect	987:1007	the inhibitory effect of SA on vivianite precipitation	987:1040	It was worth noting that the inhibitory effect of SA on vivianite precipitation decreased with increasing initial pH and Fe/P molar ratios.
32446452	1	3	theme	vivianite	148:156	arg1	crystallization					158:172	vivianite crystallization	148:172	vivianite crystallization	148:172	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	7	4	from	rods	1260:1263	arg1	sizes					1275:1279	uneven sizes	1268:1279	uneven sizes	1268:1279	Additionally, SA has no obvious influence on the composition of products, but the morphology of harvested crystals was transformed from branches to plates or rods in uneven sizes.
32446452	5	5	theme	inhibition	880:889	arg1	times					923:927	about 3 times	915:927	about 3 times as large as that of 400 mg/L SA	915:959	The inhibition rate of 800 mg/L SA was about 3 times as large as that of 400 mg/L SA.
32446452	5	5	theme	inhibition	880:889	arg1	rate					891:894	The inhibition rate	876:894	The inhibition rate of 800 mg/L SA	876:909	The inhibition rate of 800 mg/L SA was about 3 times as large as that of 400 mg/L SA.
32446452	7	6	theme	crystals	1208:1215	arg1	morphology					1184:1193	the morphology	1180:1193	the morphology of harvested crystals	1180:1215	Additionally, SA has no obvious influence on the composition of products, but the morphology of harvested crystals was transformed from branches to plates or rods in uneven sizes.
32446452	0	7	from	Effect	0:5	arg1	recovery					40:47	phosphorus recovery	29:47	phosphorus recovery by vivianite precipitation	29:74	Effect of sodium alginate on phosphorus recovery by vivianite precipitation.
32446452	4	8	theme	SA	857:858	arg1	concentrations					860:873	SA concentrations	857:873	SA concentrations	857:873	However, when the concentration of SA was larger than 400 mg/L, the phosphorus recovery rate decreased significantly with increasing SA concentrations.
32446452	1	9	theme	vivianite	263:271	arg1	precipitation					273:285	vivianite precipitation	263:285	vivianite precipitation	263:285	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	7	10	theme	harvested	1198:1206	arg1	crystals					1208:1215	harvested crystals	1198:1215	harvested crystals	1198:1215	Additionally, SA has no obvious influence on the composition of products, but the morphology of harvested crystals was transformed from branches to plates or rods in uneven sizes.
32446452	1	11	from	sludge	138:143	arg1	recovery					117:124	phosphorus recovery	106:124	phosphorus recovery from excess sludge by vivianite crystallization	106:172	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	5	12	theme	large	932:936	arg1	times					923:927	about 3 times	915:927	about 3 times as large as that of 400 mg/L SA	915:959	The inhibition rate of 800 mg/L SA was about 3 times as large as that of 400 mg/L SA.
32446452	5	12	theme	large	932:936	arg1	rate					891:894	The inhibition rate	876:894	The inhibition rate of 800 mg/L SA	876:909	The inhibition rate of 800 mg/L SA was about 3 times as large as that of 400 mg/L SA.
32446452	5	13	theme	SA	908:909	arg1	times					923:927	about 3 times	915:927	about 3 times as large as that of 400 mg/L SA	915:959	The inhibition rate of 800 mg/L SA was about 3 times as large as that of 400 mg/L SA.
32446452	5	13	theme	SA	908:909	arg1	rate					891:894	The inhibition rate	876:894	The inhibition rate of 800 mg/L SA	876:909	The inhibition rate of 800 mg/L SA was about 3 times as large as that of 400 mg/L SA.
32446452	3	14	from	SA	625:626	arg1	concentrations					635:648	low concentrations	631:648	low concentrations (≤400 mg/L)	631:660	The results showed that SA in low concentrations (≤400 mg/L) had little inhibitory effect on the phosphorus recovery rate.
32446452	3	14	from	SA	625:626	arg1	≤400 mg/L					651:659	≤400 mg/L	651:659	≤400 mg/L	651:659	The results showed that SA in low concentrations (≤400 mg/L) had little inhibitory effect on the phosphorus recovery rate.
32446452	2	15	theme	substance	350:358	arg1	effect					365:370	the effect	361:370	the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1)	361:554	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	15	theme	substance	350:358	arg1	representative					308:321	a representative	306:321	a representative of extracellular polymeric substance	306:358	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	4	16	theme	recovery	803:810	arg1	rate					812:815	the phosphorus recovery rate	788:815	the phosphorus recovery rate	788:815	However, when the concentration of SA was larger than 400 mg/L, the phosphorus recovery rate decreased significantly with increasing SA concentrations.
32446452	2	17	theme	phosphorus	399:408	arg1	recovery					410:417	phosphorus recovery	399:417	phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1)	399:554	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	18	theme	alginate	382:389	arg1	effect					365:370	the effect	361:370	the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1)	361:554	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	18	theme	alginate	382:389	arg1	representative					308:321	a representative	306:321	a representative of extracellular polymeric substance	306:358	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	6	19	theme	vivianite	1018:1026	arg1	precipitation					1028:1040	vivianite precipitation	1018:1040	vivianite precipitation	1018:1040	It was worth noting that the inhibitory effect of SA on vivianite precipitation decreased with increasing initial pH and Fe/P molar ratios.
32446452	2	20	theme	pH	502:503	arg1	values					505:510	pH values	502:510	pH values (6.5-9.0)	502:520	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	20	theme	pH	502:503	arg1	6.5-9.0					513:519	6.5-9.0	513:519	6.5-9.0	513:519	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	4	21	theme	phosphorus	792:801	arg1	rate					812:815	the phosphorus recovery rate	788:815	the phosphorus recovery rate	788:815	However, when the concentration of SA was larger than 400 mg/L, the phosphorus recovery rate decreased significantly with increasing SA concentrations.
32446452	7	22	theme	obvious	1126:1132	arg1	influence					1134:1142	no obvious influence	1123:1142	no obvious influence	1123:1142	Additionally, SA has no obvious influence on the composition of products, but the morphology of harvested crystals was transformed from branches to plates or rods in uneven sizes.
32446452	3	23	theme	phosphorus	698:707	arg1	rate					718:721	the phosphorus recovery rate	694:721	the phosphorus recovery rate	694:721	The results showed that SA in low concentrations (≤400 mg/L) had little inhibitory effect on the phosphorus recovery rate.
32446452	1	24	theme	large	182:186	arg1	number					188:193	a large number	180:193	a large number of extracellular polymeric substances in sludge	180:241	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	6	25	from	effect	1002:1007	arg1	precipitation					1028:1040	vivianite precipitation	1018:1040	vivianite precipitation	1018:1040	It was worth noting that the inhibitory effect of SA on vivianite precipitation decreased with increasing initial pH and Fe/P molar ratios.
32446452	1	26	theme	good	87:90	arg1	prospects					92:100	good prospects	87:100	good prospects for phosphorus recovery from excess sludge by vivianite crystallization	87:172	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	2	27	theme	sodium	375:380	arg1	SA					392:393	SA	392:393	SA	392:393	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	27	theme	sodium	375:380	arg1	alginate					382:389	sodium alginate	375:389	sodium alginate (SA)	375:394	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	28	theme	vivianite	422:430	arg1	precipitation					432:444	vivianite precipitation	422:444	vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1)	422:554	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	29	theme	molar	531:535	arg1	1:1-2.4:1					545:553	1:1-2.4:1	545:553	1:1-2.4:1	545:553	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	29	theme	molar	531:535	arg1	ratios					537:542	Fe/P molar ratios	526:542	Fe/P molar ratios (1:1-2.4:1)	526:554	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	30	from	effect	365:370	arg1	recovery					410:417	phosphorus recovery	399:417	phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1)	399:554	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	0	31	theme	sodium	10:15	arg1	alginate					17:24	sodium alginate	10:24	sodium alginate	10:24	Effect of sodium alginate on phosphorus recovery by vivianite precipitation.
32446452	3	32	theme	recovery	709:716	arg1	rate					718:721	the phosphorus recovery rate	694:721	the phosphorus recovery rate	694:721	The results showed that SA in low concentrations (≤400 mg/L) had little inhibitory effect on the phosphorus recovery rate.
32446452	2	33	theme	Fe/P	526:529	arg1	1:1-2.4:1					545:553	1:1-2.4:1	545:553	1:1-2.4:1	545:553	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	33	theme	Fe/P	526:529	arg1	ratios					537:542	Fe/P molar ratios	526:542	Fe/P molar ratios (1:1-2.4:1)	526:554	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	6	34	theme	molar	1088:1092	arg1	ratios					1094:1099	Fe/P molar ratios	1083:1099	Fe/P molar ratios	1083:1099	It was worth noting that the inhibitory effect of SA on vivianite precipitation decreased with increasing initial pH and Fe/P molar ratios.
32446452	1	35	theme	extracellular	198:210	arg1	substances					222:231	extracellular polymeric substances	198:231	extracellular polymeric substances in sludge	198:241	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	0	36	theme	phosphorus	29:38	arg1	recovery					40:47	phosphorus recovery	29:47	phosphorus recovery by vivianite precipitation	29:74	Effect of sodium alginate on phosphorus recovery by vivianite precipitation.
32446452	1	37	contain	have	248:251	arg1	number					188:193	a large number	180:193	a large number of extracellular polymeric substances in sludge	180:241	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	1	37	contain	have	248:251	arg2	impact					253:258	impact	253:258	impact	253:258	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	1	38	theme	polymeric	212:220	arg1	substances					222:231	extracellular polymeric substances	198:231	extracellular polymeric substances in sludge	198:241	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	2	39	theme	SA	470:471	arg1	0-800 mg/L					489:498	0-800 mg/L	489:498	0-800 mg/L	489:498	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	39	theme	SA	470:471	arg1	concentrations					473:486	different initial SA concentrations	452:486	different initial SA concentrations (0-800 mg/L)	452:499	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	0	40	theme	alginate	17:24	arg1	Effect					0:5	Effect	0:5	Effect of sodium alginate on phosphorus recovery by vivianite precipitation.	0:75	Effect of sodium alginate on phosphorus recovery by vivianite precipitation.
32446452	1	41	theme	substances	222:231	arg1	number					188:193	a large number	180:193	a large number of extracellular polymeric substances in sludge	180:241	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	2	42	theme	initial	462:468	arg1	0-800 mg/L					489:498	0-800 mg/L	489:498	0-800 mg/L	489:498	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	42	theme	initial	462:468	arg1	concentrations					473:486	different initial SA concentrations	452:486	different initial SA concentrations (0-800 mg/L)	452:499	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	1	43	from	substances	222:231	arg1	sludge					236:241	sludge	236:241	sludge	236:241	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	1	44	theme	phosphorus	106:115	arg1	recovery					117:124	phosphorus recovery	106:124	phosphorus recovery from excess sludge by vivianite crystallization	106:172	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	2	45	theme	different	452:460	arg1	0-800 mg/L					489:498	0-800 mg/L	489:498	0-800 mg/L	489:498	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	45	theme	different	452:460	arg1	concentrations					473:486	different initial SA concentrations	452:486	different initial SA concentrations (0-800 mg/L)	452:499	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	2	46	theme	polymeric	340:348	arg1	substance					350:358	extracellular polymeric substance	326:358	extracellular polymeric substance	326:358	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	7	47	contain	has	1119:1121	arg1	SA					1116:1117	SA	1116:1117	SA	1116:1117	Additionally, SA has no obvious influence on the composition of products, but the morphology of harvested crystals was transformed from branches to plates or rods in uneven sizes.
32446452	7	47	contain	has	1119:1121	arg2	influence					1134:1142	no obvious influence	1123:1142	no obvious influence	1123:1142	Additionally, SA has no obvious influence on the composition of products, but the morphology of harvested crystals was transformed from branches to plates or rods in uneven sizes.
32446452	4	48	theme	SA	759:760	arg1	larger					766:771	larger	766:771	larger	766:771	However, when the concentration of SA was larger than 400 mg/L, the phosphorus recovery rate decreased significantly with increasing SA concentrations.
32446452	4	48	theme	SA	759:760	arg1	concentration					742:754	the concentration	738:754	the concentration of SA	738:760	However, when the concentration of SA was larger than 400 mg/L, the phosphorus recovery rate decreased significantly with increasing SA concentrations.
32446452	7	49	from	plates	1250:1255	arg1	sizes					1275:1279	uneven sizes	1268:1279	uneven sizes	1268:1279	Additionally, SA has no obvious influence on the composition of products, but the morphology of harvested crystals was transformed from branches to plates or rods in uneven sizes.
32446452	2	50	theme	extracellular	326:338	arg1	substance					350:358	extracellular polymeric substance	326:358	extracellular polymeric substance	326:358	In this study, as a representative of extracellular polymeric substance, the effect of sodium alginate (SA) on phosphorus recovery by vivianite precipitation under different initial SA concentrations (0-800 mg/L), pH values (6.5-9.0) and Fe/P molar ratios (1:1-2.4:1) was investigated using synthetic wastewater.
32446452	6	51	theme	initial	1068:1074	arg1	pH					1076:1077	initial pH	1068:1077	initial pH	1068:1077	It was worth noting that the inhibitory effect of SA on vivianite precipitation decreased with increasing initial pH and Fe/P molar ratios.
32446452	6	52	theme	SA	1012:1013	arg1	effect					1002:1007	the inhibitory effect	987:1007	the inhibitory effect of SA on vivianite precipitation	987:1040	It was worth noting that the inhibitory effect of SA on vivianite precipitation decreased with increasing initial pH and Fe/P molar ratios.
32446452	1	53	from	sludge	236:241	arg1	number					188:193	a large number	180:193	a large number of extracellular polymeric substances in sludge	180:241	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	3	54	theme	low	631:633	arg1	concentrations					635:648	low concentrations	631:648	low concentrations (≤400 mg/L)	631:660	The results showed that SA in low concentrations (≤400 mg/L) had little inhibitory effect on the phosphorus recovery rate.
32446452	3	54	theme	low	631:633	arg1	≤400 mg/L					651:659	≤400 mg/L	651:659	≤400 mg/L	651:659	The results showed that SA in low concentrations (≤400 mg/L) had little inhibitory effect on the phosphorus recovery rate.
32446452	5	55	theme	400 mg/L	949:956	arg1	SA					958:959	400 mg/L SA	949:959	400 mg/L SA	949:959	The inhibition rate of 800 mg/L SA was about 3 times as large as that of 400 mg/L SA.
32446452	1	56	theme	excess	131:136	arg1	sludge					138:143	excess sludge	131:143	excess sludge	131:143	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	6	57	theme	Fe/P	1083:1086	arg1	ratios					1094:1099	Fe/P molar ratios	1083:1099	Fe/P molar ratios	1083:1099	It was worth noting that the inhibitory effect of SA on vivianite precipitation decreased with increasing initial pH and Fe/P molar ratios.
32446452	5	58	theme	800 mg/L	899:906	arg1	SA					908:909	800 mg/L SA	899:909	800 mg/L SA	899:909	The inhibition rate of 800 mg/L SA was about 3 times as large as that of 400 mg/L SA.
32446452	7	59	theme	products	1166:1173	arg1	composition					1151:1161	the composition	1147:1161	the composition of products	1147:1173	Additionally, SA has no obvious influence on the composition of products, but the morphology of harvested crystals was transformed from branches to plates or rods in uneven sizes.
32446452	1	60	from	number	188:193	arg1	sludge					236:241	sludge	236:241	sludge	236:241	There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.
32446452	3	61	contain	had	662:664	arg1	SA					625:626	SA	625:626	SA in low concentrations (≤400 mg/L)	625:660	The results showed that SA in low concentrations (≤400 mg/L) had little inhibitory effect on the phosphorus recovery rate.
32446452	3	61	contain	had	662:664	arg2	effect					684:689	little inhibitory effect	666:689	little inhibitory effect	666:689	The results showed that SA in low concentrations (≤400 mg/L) had little inhibitory effect on the phosphorus recovery rate.
32446452	7	62	theme	uneven	1268:1273	arg1	sizes					1275:1279	uneven sizes	1268:1279	uneven sizes	1268:1279	Additionally, SA has no obvious influence on the composition of products, but the morphology of harvested crystals was transformed from branches to plates or rods in uneven sizes.
32446452	0	63	theme	vivianite	52:60	arg1	precipitation					62:74	vivianite precipitation	52:74	vivianite precipitation	52:74	Effect of sodium alginate on phosphorus recovery by vivianite precipitation.
32446452	3	64	theme	little	666:671	arg1	effect					684:689	little inhibitory effect	666:689	little inhibitory effect	666:689	The results showed that SA in low concentrations (≤400 mg/L) had little inhibitory effect on the phosphorus recovery rate.
33481586	9	0	with	consistent	1292:1301	arg1	requirements					1320:1331	the end-use requirements	1308:1331	the end-use requirements of barley grain	1308:1347	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	1	theme	grain	1343:1347	arg1	requirements					1320:1331	the end-use requirements	1308:1331	the end-use requirements of barley grain	1308:1347	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	2	from	low	1187:1189	arg1	5/24					1223:1226	5/24	1223:1226	5/24	1223:1226	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	2	from	low	1187:1189	arg1	46/74					1284:1288	46/74	1284:1288	46/74	1284:1288	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	2	from	low	1187:1189	arg1	cultivars					1212:1220	Australian barley cultivars	1194:1220	Australian barley cultivars (5/24)	1194:1227	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	2	from	low	1187:1189	arg1	cultivars					1273:1281	much higher in Tibetan hull-less barley cultivars	1233:1281	much higher in Tibetan hull-less barley cultivars (46/74)	1233:1289	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	4	3	from	association	441:451	arg1	barley					486:491	barley	486:491	barley	486:491	However, there are few reports on the association of natural variation of SSIIa in barley and grain composition and characteristics.
33481586	4	3	from	association	441:451	arg1	composition					503:513	grain composition	497:513	grain composition	497:513	However, there are few reports on the association of natural variation of SSIIa in barley and grain composition and characteristics.
33481586	8	4	theme	Chinese	1113:1119	arg1	cultivars					1128:1136	SSIIa Chinese barley cultivars	1107:1136	SSIIa Chinese barley cultivars	1107:1136	Kernel hardness of SSIIa genotypes was significantly higher than that of SSIIa Chinese barley cultivars.
33481586	6	5	theme	SSIIa	756:760	arg1	gene					762:765	the SSIIa gene	752:765	the SSIIa gene	752:765	Sequence analysis of the SSIIa gene demonstrated that a 33 bp insertion coding a peptide of APPSSVVPAKK caused different SSIIa, e.g., SSIIaH and SSIIaL.
33481586	2	6	from	important	297:305	arg1	biosynthesis					322:333	amylopectin biosynthesis	310:333	amylopectin biosynthesis	310:333	Starch synthase IIa (SSIIa) is well-known to be one of the major starch synthases and is very important in amylopectin biosynthesis.
33481586	9	7	theme	SSIIa	1157:1161	arg1	genotypes					1163:1171	SSIIa genotypes	1157:1171	SSIIa genotypes	1157:1171	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	2	8	theme	major	262:266	arg1	synthases					275:283	the major starch synthases	258:283	the major starch synthases	258:283	Starch synthase IIa (SSIIa) is well-known to be one of the major starch synthases and is very important in amylopectin biosynthesis.
33481586	3	9	contain	has	339:341	arg1	It					336:337	It	336:337	It	336:337	It has significant effects on grain composition and kernel traits.
33481586	3	9	contain	has	339:341	arg2	effects					355:361	significant effects	343:361	significant effects	343:361	It has significant effects on grain composition and kernel traits.
33481586	10	10	theme	end-use	1516:1522	arg1	requirements					1524:1535	the end-use requirements	1512:1535	the end-use requirements	1512:1535	This study provided new information in barley endosperm starch synthesis and indicated that it is valuable for choosing the preferred SSIIa genotype according to the end-use requirements.
33481586	7	11	theme	SSIIa	1010:1014	arg1	genotypes					1016:1024	different SSIIa genotypes	1000:1024	different SSIIa genotypes	1000:1024	Based on this molecular difference, a polymerase chain reaction marker was developed, which could be used to screen different SSIIa genotypes easily.
33481586	1	12	theme	starch	177:182	arg1	enzymes					194:200	multiple starch synthetic enzymes	168:200	multiple starch synthetic enzymes	168:200	Starch biosynthesis in cereal crops is a complex pathway regulated by multiple starch synthetic enzymes.
33481586	2	13	theme	synthase	210:217	arg1	SSIIa					224:228	SSIIa	224:228	SSIIa	224:228	Starch synthase IIa (SSIIa) is well-known to be one of the major starch synthases and is very important in amylopectin biosynthesis.
33481586	2	13	theme	synthase	210:217	arg1	IIa					219:221	Starch synthase IIa	203:221	Starch synthase IIa (SSIIa)	203:229	Starch synthase IIa (SSIIa) is well-known to be one of the major starch synthases and is very important in amylopectin biosynthesis.
33481586	7	14	used	used	985:988	arg2	which					970:974	which	970:974	which	970:974	Based on this molecular difference, a polymerase chain reaction marker was developed, which could be used to screen different SSIIa genotypes easily.
33481586	5	15	theme	one-dimensional	615:629	arg1	electrophoresis					673:687	one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis	615:687	one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis	615:687	In this work, two SSIIa isoforms were first identified as SSIIaH and SSIIaL by one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis, mass spectrometry, and Western blotting.
33481586	9	16	theme	Australian	1194:1203	arg1	5/24					1223:1226	5/24	1223:1226	5/24	1223:1226	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	16	theme	Australian	1194:1203	arg1	cultivars					1212:1220	Australian barley cultivars	1194:1220	Australian barley cultivars (5/24)	1194:1227	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	1	17	theme	Starch	98:103	arg1	biosynthesis					105:116	Starch biosynthesis	98:116	Starch biosynthesis in cereal crops	98:132	Starch biosynthesis in cereal crops is a complex pathway regulated by multiple starch synthetic enzymes.
33481586	1	17	theme	Starch	98:103	arg1	pathway					147:153	a complex pathway	137:153	a complex pathway regulated by multiple starch synthetic enzymes	137:200	Starch biosynthesis in cereal crops is a complex pathway regulated by multiple starch synthetic enzymes.
33481586	7	18	theme	chain	933:937	arg1	reaction					939:946	a polymerase chain reaction	920:946	a polymerase chain reaction marker	920:953	Based on this molecular difference, a polymerase chain reaction marker was developed, which could be used to screen different SSIIa genotypes easily.
33481586	0	19	theme	Grain	47:51	arg1	Components					53:62	Grain Components	47:62	Grain Components	47:62	Effects of Two Starch Synthase IIa Isoforms on Grain Components and Other Grain Traits in Barley.
33481586	0	20	from	Effects	0:6	arg1	Traits					80:85	Other Grain Traits	68:85	Other Grain Traits in Barley	68:95	Effects of Two Starch Synthase IIa Isoforms on Grain Components and Other Grain Traits in Barley.
33481586	0	20	from	Effects	0:6	arg1	Components					53:62	Grain Components	47:62	Grain Components	47:62	Effects of Two Starch Synthase IIa Isoforms on Grain Components and Other Grain Traits in Barley.
33481586	0	21	theme	Grain	74:78	arg1	Traits					80:85	Other Grain Traits	68:85	Other Grain Traits in Barley	68:95	Effects of Two Starch Synthase IIa Isoforms on Grain Components and Other Grain Traits in Barley.
33481586	9	22	theme	higher	1238:1243	arg1	46/74					1284:1288	46/74	1284:1288	46/74	1284:1288	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	22	theme	higher	1238:1243	arg1	cultivars					1273:1281	much higher in Tibetan hull-less barley cultivars	1233:1281	much higher in Tibetan hull-less barley cultivars (46/74)	1233:1289	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	4	23	theme	few	422:424	arg1	reports					426:432	few reports	422:432	few reports on the association of natural variation of SSIIa in barley and grain composition and characteristics	422:533	However, there are few reports on the association of natural variation of SSIIa in barley and grain composition and characteristics.
33481586	10	24	theme	starch	1406:1411	arg1	synthesis					1413:1421	barley endosperm starch synthesis	1389:1421	barley endosperm starch synthesis	1389:1421	This study provided new information in barley endosperm starch synthesis and indicated that it is valuable for choosing the preferred SSIIa genotype according to the end-use requirements.
33481586	0	25	theme	IIa	31:33	arg1	Isoforms					35:42	Two Starch Synthase IIa Isoforms	11:42	Two Starch Synthase IIa Isoforms	11:42	Effects of Two Starch Synthase IIa Isoforms on Grain Components and Other Grain Traits in Barley.
33481586	1	26	from	biosynthesis	105:116	arg1	crops					128:132	cereal crops	121:132	cereal crops	121:132	Starch biosynthesis in cereal crops is a complex pathway regulated by multiple starch synthetic enzymes.
33481586	10	27	theme	barley	1389:1394	arg1	synthesis					1413:1421	barley endosperm starch synthesis	1389:1421	barley endosperm starch synthesis	1389:1421	This study provided new information in barley endosperm starch synthesis and indicated that it is valuable for choosing the preferred SSIIa genotype according to the end-use requirements.
33481586	4	28	from	composition	503:513	arg1	association					441:451	the association	437:451	the association of natural variation of SSIIa in barley and grain composition and characteristics	437:533	However, there are few reports on the association of natural variation of SSIIa in barley and grain composition and characteristics.
33481586	9	29	theme	barley	1266:1271	arg1	46/74					1284:1288	46/74	1284:1288	46/74	1284:1288	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	29	theme	barley	1266:1271	arg1	cultivars					1273:1281	much higher in Tibetan hull-less barley cultivars	1233:1281	much higher in Tibetan hull-less barley cultivars (46/74)	1233:1289	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	30	from	cultivars	1273:1281	arg1	low					1187:1189	low	1187:1189	low	1187:1189	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	30	from	cultivars	1273:1281	arg1	proportion					1143:1152	The proportion	1139:1152	The proportion of SSIIa genotypes	1139:1171	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	6	31	theme	APPSSVVPAKK	823:833	arg1	peptide					812:818	a peptide	810:818	a peptide of APPSSVVPAKK	810:833	Sequence analysis of the SSIIa gene demonstrated that a 33 bp insertion coding a peptide of APPSSVVPAKK caused different SSIIa, e.g., SSIIaH and SSIIaL.
33481586	3	32	theme	grain	366:370	arg1	composition					372:382	grain composition	366:382	grain composition	366:382	It has significant effects on grain composition and kernel traits.
33481586	0	33	theme	Synthase	22:29	arg1	Isoforms					35:42	Two Starch Synthase IIa Isoforms	11:42	Two Starch Synthase IIa Isoforms	11:42	Effects of Two Starch Synthase IIa Isoforms on Grain Components and Other Grain Traits in Barley.
33481586	0	34	theme	Isoforms	35:42	arg1	Effects					0:6	Effects	0:6	Effects of Two Starch Synthase IIa Isoforms on Grain Components and Other Grain Traits in Barley	0:95	Effects of Two Starch Synthase IIa Isoforms on Grain Components and Other Grain Traits in Barley.
33481586	8	35	theme	SSIIa	1053:1057	arg1	genotypes					1059:1067	SSIIa genotypes	1053:1067	SSIIa genotypes	1053:1067	Kernel hardness of SSIIa genotypes was significantly higher than that of SSIIa Chinese barley cultivars.
33481586	6	36	theme	bp	790:791	arg1	insertion					793:801	a 33 bp insertion	785:801	a 33 bp insertion coding a peptide of APPSSVVPAKK	785:833	Sequence analysis of the SSIIa gene demonstrated that a 33 bp insertion coding a peptide of APPSSVVPAKK caused different SSIIa, e.g., SSIIaH and SSIIaL.
33481586	10	37	theme	SSIIa	1484:1488	arg1	genotype					1490:1497	the preferred SSIIa genotype	1470:1497	the preferred SSIIa genotype	1470:1497	This study provided new information in barley endosperm starch synthesis and indicated that it is valuable for choosing the preferred SSIIa genotype according to the end-use requirements.
33481586	4	38	from	variation	464:472	arg1	barley					486:491	barley	486:491	barley	486:491	However, there are few reports on the association of natural variation of SSIIa in barley and grain composition and characteristics.
33481586	4	38	from	variation	464:472	arg1	composition					503:513	grain composition	497:513	grain composition	497:513	However, there are few reports on the association of natural variation of SSIIa in barley and grain composition and characteristics.
33481586	9	39	theme	barley	1336:1341	arg1	grain					1343:1347	barley grain	1336:1347	barley grain	1336:1347	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	6	40	dep	SSIIaH	865:870	arg1	e.g.					859:862	e.g.	859:862	e.g.	859:862	Sequence analysis of the SSIIa gene demonstrated that a 33 bp insertion coding a peptide of APPSSVVPAKK caused different SSIIa, e.g., SSIIaH and SSIIaL.
33481586	6	41	theme	gene	762:765	arg1	analysis					740:747	Sequence analysis	731:747	Sequence analysis of the SSIIa gene	731:765	Sequence analysis of the SSIIa gene demonstrated that a 33 bp insertion coding a peptide of APPSSVVPAKK caused different SSIIa, e.g., SSIIaH and SSIIaL.
33481586	1	42	theme	complex	139:145	arg1	biosynthesis					105:116	Starch biosynthesis	98:116	Starch biosynthesis in cereal crops	98:132	Starch biosynthesis in cereal crops is a complex pathway regulated by multiple starch synthetic enzymes.
33481586	1	42	theme	complex	139:145	arg1	pathway					147:153	a complex pathway	137:153	a complex pathway regulated by multiple starch synthetic enzymes	137:200	Starch biosynthesis in cereal crops is a complex pathway regulated by multiple starch synthetic enzymes.
33481586	8	43	theme	SSIIa	1107:1111	arg1	cultivars					1128:1136	SSIIa Chinese barley cultivars	1107:1136	SSIIa Chinese barley cultivars	1107:1136	Kernel hardness of SSIIa genotypes was significantly higher than that of SSIIa Chinese barley cultivars.
33481586	6	44	theme	different	842:850	arg1	SSIIa					852:856	different SSIIa	842:856	different SSIIa	842:856	Sequence analysis of the SSIIa gene demonstrated that a 33 bp insertion coding a peptide of APPSSVVPAKK caused different SSIIa, e.g., SSIIaH and SSIIaL.
33481586	4	45	from	reports	426:432	arg1	association					441:451	the association	437:451	the association of natural variation of SSIIa in barley and grain composition and characteristics	437:533	However, there are few reports on the association of natural variation of SSIIa in barley and grain composition and characteristics.
33481586	2	46	theme	starch	268:273	arg1	synthases					275:283	the major starch synthases	258:283	the major starch synthases	258:283	Starch synthase IIa (SSIIa) is well-known to be one of the major starch synthases and is very important in amylopectin biosynthesis.
33481586	8	47	theme	barley	1121:1126	arg1	cultivars					1128:1136	SSIIa Chinese barley cultivars	1107:1136	SSIIa Chinese barley cultivars	1107:1136	Kernel hardness of SSIIa genotypes was significantly higher than that of SSIIa Chinese barley cultivars.
33481586	2	48	from	biosynthesis	322:333	arg1	important					297:305	important	297:305	important	297:305	Starch synthase IIa (SSIIa) is well-known to be one of the major starch synthases and is very important in amylopectin biosynthesis.
33481586	7	49	theme	different	1000:1008	arg1	genotypes					1016:1024	different SSIIa genotypes	1000:1024	different SSIIa genotypes	1000:1024	Based on this molecular difference, a polymerase chain reaction marker was developed, which could be used to screen different SSIIa genotypes easily.
33481586	9	50	theme	genotypes	1163:1171	arg1	low					1187:1189	low	1187:1189	low	1187:1189	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	50	theme	genotypes	1163:1171	arg1	proportion					1143:1152	The proportion	1139:1152	The proportion of SSIIa genotypes	1139:1171	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	1	51	theme	multiple	168:175	arg1	enzymes					194:200	multiple starch synthetic enzymes	168:200	multiple starch synthetic enzymes	168:200	Starch biosynthesis in cereal crops is a complex pathway regulated by multiple starch synthetic enzymes.
33481586	10	52	from	information	1374:1384	arg1	synthesis					1413:1421	barley endosperm starch synthesis	1389:1421	barley endosperm starch synthesis	1389:1421	This study provided new information in barley endosperm starch synthesis and indicated that it is valuable for choosing the preferred SSIIa genotype according to the end-use requirements.
33481586	1	53	theme	synthetic	184:192	arg1	enzymes					194:200	multiple starch synthetic enzymes	168:200	multiple starch synthetic enzymes	168:200	Starch biosynthesis in cereal crops is a complex pathway regulated by multiple starch synthetic enzymes.
33481586	0	54	from	Components	53:62	arg1	Barley					90:95	Barley	90:95	Barley	90:95	Effects of Two Starch Synthase IIa Isoforms on Grain Components and Other Grain Traits in Barley.
33481586	2	55	theme	Starch	203:208	arg1	SSIIa					224:228	SSIIa	224:228	SSIIa	224:228	Starch synthase IIa (SSIIa) is well-known to be one of the major starch synthases and is very important in amylopectin biosynthesis.
33481586	2	55	theme	Starch	203:208	arg1	IIa					219:221	Starch synthase IIa	203:221	Starch synthase IIa (SSIIa)	203:229	Starch synthase IIa (SSIIa) is well-known to be one of the major starch synthases and is very important in amylopectin biosynthesis.
33481586	4	56	theme	natural	456:462	arg1	variation					464:472	natural variation	456:472	natural variation of SSIIa in barley and grain composition and characteristics	456:533	However, there are few reports on the association of natural variation of SSIIa in barley and grain composition and characteristics.
33481586	5	57	theme	sulfate-polyacrylamide	646:667	arg1	electrophoresis					673:687	one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis	615:687	one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis	615:687	In this work, two SSIIa isoforms were first identified as SSIIaH and SSIIaL by one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis, mass spectrometry, and Western blotting.
33481586	9	58	theme	barley	1205:1210	arg1	5/24					1223:1226	5/24	1223:1226	5/24	1223:1226	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	58	theme	barley	1205:1210	arg1	cultivars					1212:1220	Australian barley cultivars	1194:1220	Australian barley cultivars (5/24)	1194:1227	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	0	59	from	Traits	80:85	arg1	Barley					90:95	Barley	90:95	Barley	90:95	Effects of Two Starch Synthase IIa Isoforms on Grain Components and Other Grain Traits in Barley.
33481586	5	60	theme	Western	713:719	arg1	blotting					721:728	Western blotting	713:728	Western blotting	713:728	In this work, two SSIIa isoforms were first identified as SSIIaH and SSIIaL by one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis, mass spectrometry, and Western blotting.
33481586	7	61	theme	reaction	939:946	arg1	marker					948:953	a polymerase chain reaction marker	920:953	a polymerase chain reaction marker	920:953	Based on this molecular difference, a polymerase chain reaction marker was developed, which could be used to screen different SSIIa genotypes easily.
33481586	1	62	theme	cereal	121:126	arg1	crops					128:132	cereal crops	121:132	cereal crops	121:132	Starch biosynthesis in cereal crops is a complex pathway regulated by multiple starch synthetic enzymes.
33481586	0	63	theme	Other	68:72	arg1	Traits					80:85	Other Grain Traits	68:85	Other Grain Traits in Barley	68:95	Effects of Two Starch Synthase IIa Isoforms on Grain Components and Other Grain Traits in Barley.
33481586	7	64	theme	polymerase	922:931	arg1	reaction					939:946	a polymerase chain reaction	920:946	a polymerase chain reaction marker	920:953	Based on this molecular difference, a polymerase chain reaction marker was developed, which could be used to screen different SSIIa genotypes easily.
33481586	5	65	theme	gel	669:671	arg1	electrophoresis					673:687	one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis	615:687	one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis	615:687	In this work, two SSIIa isoforms were first identified as SSIIaH and SSIIaL by one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis, mass spectrometry, and Western blotting.
33481586	4	66	theme	variation	464:472	arg1	association					441:451	the association	437:451	the association of natural variation of SSIIa in barley and grain composition and characteristics	437:533	However, there are few reports on the association of natural variation of SSIIa in barley and grain composition and characteristics.
33481586	10	67	theme	new	1370:1372	arg1	information					1374:1384	new information	1370:1384	new information in barley endosperm starch synthesis	1370:1421	This study provided new information in barley endosperm starch synthesis and indicated that it is valuable for choosing the preferred SSIIa genotype according to the end-use requirements.
33481586	5	68	theme	mass	690:693	arg1	spectrometry					695:706	mass spectrometry	690:706	mass spectrometry	690:706	In this work, two SSIIa isoforms were first identified as SSIIaH and SSIIaL by one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis, mass spectrometry, and Western blotting.
33481586	5	69	theme	SSIIa	554:558	arg1	SSIIaH					594:599	SSIIaH	594:599	SSIIaH	594:599	In this work, two SSIIa isoforms were first identified as SSIIaH and SSIIaL by one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis, mass spectrometry, and Western blotting.
33481586	5	69	theme	SSIIa	554:558	arg1	isoforms					560:567	two SSIIa isoforms	550:567	two SSIIa isoforms	550:567	In this work, two SSIIa isoforms were first identified as SSIIaH and SSIIaL by one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis, mass spectrometry, and Western blotting.
33481586	5	69	theme	SSIIa	554:558	arg1	SSIIaL					605:610	SSIIaL	605:610	SSIIaL	605:610	In this work, two SSIIa isoforms were first identified as SSIIaH and SSIIaL by one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis, mass spectrometry, and Western blotting.
33481586	10	70	theme	endosperm	1396:1404	arg1	synthesis					1413:1421	barley endosperm starch synthesis	1389:1421	barley endosperm starch synthesis	1389:1421	This study provided new information in barley endosperm starch synthesis and indicated that it is valuable for choosing the preferred SSIIa genotype according to the end-use requirements.
33481586	9	71	theme	hull-less	1256:1264	arg1	46/74					1284:1288	46/74	1284:1288	46/74	1284:1288	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	71	theme	hull-less	1256:1264	arg1	cultivars					1273:1281	much higher in Tibetan hull-less barley cultivars	1233:1281	much higher in Tibetan hull-less barley cultivars (46/74)	1233:1289	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	3	72	theme	significant	343:353	arg1	effects					355:361	significant effects	343:361	significant effects	343:361	It has significant effects on grain composition and kernel traits.
33481586	4	73	theme	grain	497:501	arg1	composition					503:513	grain composition	497:513	grain composition	497:513	However, there are few reports on the association of natural variation of SSIIa in barley and grain composition and characteristics.
33481586	3	74	theme	kernel	388:393	arg1	traits					395:400	kernel traits	388:400	kernel traits	388:400	It has significant effects on grain composition and kernel traits.
33481586	0	75	theme	Starch	15:20	arg1	Isoforms					35:42	Two Starch Synthase IIa Isoforms	11:42	Two Starch Synthase IIa Isoforms	11:42	Effects of Two Starch Synthase IIa Isoforms on Grain Components and Other Grain Traits in Barley.
33481586	7	76	theme	molecular	898:906	arg1	difference					908:917	this molecular difference	893:917	this molecular difference	893:917	Based on this molecular difference, a polymerase chain reaction marker was developed, which could be used to screen different SSIIa genotypes easily.
33481586	4	77	from	barley	486:491	arg1	association					441:451	the association	437:451	the association of natural variation of SSIIa in barley and grain composition and characteristics	437:533	However, there are few reports on the association of natural variation of SSIIa in barley and grain composition and characteristics.
33481586	8	78	theme	Kernel	1034:1039	arg1	hardness					1041:1048	Kernel hardness	1034:1048	Kernel hardness of SSIIa genotypes	1034:1067	Kernel hardness of SSIIa genotypes was significantly higher than that of SSIIa Chinese barley cultivars.
33481586	4	79	theme	SSIIa	477:481	arg1	variation					464:472	natural variation	456:472	natural variation of SSIIa in barley and grain composition and characteristics	456:533	However, there are few reports on the association of natural variation of SSIIa in barley and grain composition and characteristics.
33481586	6	80	theme	Sequence	731:738	arg1	analysis					740:747	Sequence analysis	731:747	Sequence analysis of the SSIIa gene	731:765	Sequence analysis of the SSIIa gene demonstrated that a 33 bp insertion coding a peptide of APPSSVVPAKK caused different SSIIa, e.g., SSIIaH and SSIIaL.
33481586	8	81	theme	genotypes	1059:1067	arg1	hardness					1041:1048	Kernel hardness	1034:1048	Kernel hardness of SSIIa genotypes	1034:1067	Kernel hardness of SSIIa genotypes was significantly higher than that of SSIIa Chinese barley cultivars.
33481586	2	82	theme	synthases	275:283	arg1	synthases					275:283	the major starch synthases	258:283	the major starch synthases	258:283	Starch synthase IIa (SSIIa) is well-known to be one of the major starch synthases and is very important in amylopectin biosynthesis.
33481586	2	82	theme	synthases	275:283	arg1	one					251:253	one	251:253	one	251:253	Starch synthase IIa (SSIIa) is well-known to be one of the major starch synthases and is very important in amylopectin biosynthesis.
33481586	9	83	theme	end-use	1312:1318	arg1	requirements					1320:1331	the end-use requirements	1308:1331	the end-use requirements of barley grain	1308:1347	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	84	from	cultivars	1212:1220	arg1	low					1187:1189	low	1187:1189	low	1187:1189	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	9	84	from	cultivars	1212:1220	arg1	proportion					1143:1152	The proportion	1139:1152	The proportion of SSIIa genotypes	1139:1171	The proportion of SSIIa genotypes was extremely low in Australian barley cultivars (5/24) and much higher in Tibetan hull-less barley cultivars (46/74), consistent with the end-use requirements of barley grain.
33481586	6	85	theme	33	787:788	arg1	bp					790:791	bp	790:791	bp	790:791	Sequence analysis of the SSIIa gene demonstrated that a 33 bp insertion coding a peptide of APPSSVVPAKK caused different SSIIa, e.g., SSIIaH and SSIIaL.
33481586	10	86	theme	preferred	1474:1482	arg1	genotype					1490:1497	the preferred SSIIa genotype	1470:1497	the preferred SSIIa genotype	1470:1497	This study provided new information in barley endosperm starch synthesis and indicated that it is valuable for choosing the preferred SSIIa genotype according to the end-use requirements.
33481586	2	87	theme	amylopectin	310:320	arg1	biosynthesis					322:333	amylopectin biosynthesis	310:333	amylopectin biosynthesis	310:333	Starch synthase IIa (SSIIa) is well-known to be one of the major starch synthases and is very important in amylopectin biosynthesis.
32438355	11	0	from	terms	1896:1900	arg1	superior					1884:1891	superior	1884:1891	superior	1884:1891	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d were superior in terms of their mechanical properties and achieved a compressive strength and modulus of 272 kPa and 4.9 MPa, respectively, which is 400% greater than CH-AL scaffolds.
32438355	12	1	theme	bioactive	2227:2235	arg1	reinforcement					2237:2249	the bioactive reinforcement	2223:2249	the bioactive reinforcement of composite scaffolds for bone tissue engineering	2223:2300	The results indicate that the addition of Si into biphasic fibers, leading to the formation of silicocarnotite, makes silicocarnotite a potential candidate for the bioactive reinforcement of composite scaffolds for bone tissue engineering.
32438355	7	2	theme	mechanical	1013:1022	arg1	properties					1040:1049	The physicochemical, mechanical, and biological properties	992:1049	The physicochemical, mechanical, and biological properties of composite scaffolds fabricated by adding different fiber contents and types	992:1128	The physicochemical, mechanical, and biological properties of composite scaffolds fabricated by adding different fiber contents and types were investigated.
32438355	3	3	theme	d	522:522	arg1	times					511:515	two different reaction times	488:515	two different reaction times of 4 d and 8 d	488:530	Fibers produced with no Si incorporation using two different reaction times of 4 d and 8 d comprised two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP).
32438355	10	4	theme	better	1701:1706	arg1	properties					1719:1728	better mechanical properties	1701:1728	better mechanical properties	1701:1728	Scaffolds reinforced with silicocarnotite fibers also exhibited better mechanical properties and water uptake, compared to ones containing incorporated fibers made of Si.
32438355	9	5	theme	layer	1477:1481	arg1	characterization					1445:1460	characterization	1445:1460	characterization	1445:1460	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	9	5	theme	layer	1477:1481	arg1	testing					1433:1439	SBF testing	1429:1439	SBF testing	1429:1439	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	7	6	theme	physicochemical	996:1010	arg1	properties					1040:1049	The physicochemical, mechanical, and biological properties	992:1049	The physicochemical, mechanical, and biological properties of composite scaffolds fabricated by adding different fiber contents and types	992:1128	The physicochemical, mechanical, and biological properties of composite scaffolds fabricated by adding different fiber contents and types were investigated.
32438355	8	7	theme	high	1206:1209	arg1	porosity					1211:1218	a high porosity	1204:1218	a high porosity (66-88%)	1204:1227	The scaffolds exhibited favorable microstructures with a high porosity (66-88%) and the interconnected pores varied in size between 40 and 250 µm.
32438355	8	7	theme	high	1206:1209	arg1	%					1226:1226	66-88%	1221:1226	66-88%	1221:1226	The scaffolds exhibited favorable microstructures with a high porosity (66-88%) and the interconnected pores varied in size between 40 and 250 µm.
32438355	9	8	theme	cells	1570:1574	arg1	improvement					1354:1364	a significant improvement	1340:1364	a significant improvement in their mechanical properties	1340:1395	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	9	8	theme	cells	1570:1574	arg1	bioactivity					1410:1420	in vitro bioactivity	1401:1420	in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS)	1401:1506	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	9	8	theme	cells	1570:1574	arg1	mineralization					1534:1547	mineralization	1534:1547	mineralization	1534:1547	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	9	8	theme	cells	1570:1574	arg1	adhesion					1553:1560	adhesion	1553:1560	adhesion	1553:1560	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	9	8	theme	cells	1570:1574	arg1	proliferation					1519:1531	proliferation	1519:1531	proliferation	1519:1531	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	9	9	theme	significant	1342:1352	arg1	improvement					1354:1364	a significant improvement	1340:1364	a significant improvement in their mechanical properties	1340:1395	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	11	10	from	superior	1884:1891	arg1	terms					1896:1900	terms	1896:1900	terms of their mechanical properties	1896:1931	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d were superior in terms of their mechanical properties and achieved a compressive strength and modulus of 272 kPa and 4.9 MPa, respectively, which is 400% greater than CH-AL scaffolds.
32438355	6	11	from	µm	956:957	arg1	width					985:989	width	985:989	width	985:989	The whisker-like fibers were 10-200 µm in length and 0.2-5 µm in width.
32438355	6	11	from	µm	956:957	arg1	length					962:967	length	962:967	length	962:967	The whisker-like fibers were 10-200 µm in length and 0.2-5 µm in width.
32438355	6	11	from	µm	956:957	arg1	µm					979:980	0.2-5 µm	973:980	0.2-5 µm	973:980	The whisker-like fibers were 10-200 µm in length and 0.2-5 µm in width.
32438355	8	12	theme	favorable	1173:1181	arg1	microstructures					1183:1197	favorable microstructures	1173:1197	favorable microstructures with a high porosity (66-88%)	1173:1227	The scaffolds exhibited favorable microstructures with a high porosity (66-88%) and the interconnected pores varied in size between 40 and 250 µm.
32438355	3	13	theme	hydroxyapatite	556:569	arg1	phases					546:551	two phases	542:551	two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP)	542:617	Fibers produced with no Si incorporation using two different reaction times of 4 d and 8 d comprised two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP).
32438355	5	14	theme	reflux	768:773	arg1	conditions					775:784	reflux conditions	768:784	reflux conditions	768:784	However, the addition of Si to fibers synthesized within 8 d under reflux conditions produced biphasic fibers with 1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase.
32438355	4	15	theme	new	623:625	arg1	phases					627:632	No new phases	620:632	No new phases	620:632	No new phases were observed by adding 0.8 wt% of Si during 4 d of precipitation.
32438355	10	16	theme	mechanical	1708:1717	arg1	properties					1719:1728	better mechanical properties	1701:1728	better mechanical properties	1701:1728	Scaffolds reinforced with silicocarnotite fibers also exhibited better mechanical properties and water uptake, compared to ones containing incorporated fibers made of Si.
32438355	11	17	theme	properties	1922:1931	arg1	terms					1896:1900	terms	1896:1900	terms of their mechanical properties	1896:1931	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d were superior in terms of their mechanical properties and achieved a compressive strength and modulus of 272 kPa and 4.9 MPa, respectively, which is 400% greater than CH-AL scaffolds.
32438355	9	18	theme	alkaline	1606:1613	arg1	phosphatase					1615:1625	alkaline phosphatase	1606:1625	alkaline phosphatase	1606:1625	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	4	19	theme	Si	669:670	arg1	Si					669:670	Si	669:670	Si	669:670	No new phases were observed by adding 0.8 wt% of Si during 4 d of precipitation.
32438355	4	19	theme	Si	669:670	arg1	%					664:664	0.8 wt%	658:664	0.8 wt% of Si	658:670	No new phases were observed by adding 0.8 wt% of Si during 4 d of precipitation.
32438355	9	20	from	adhesion	1553:1560	arg1	properties					1386:1395	their mechanical properties	1369:1395	their mechanical properties	1369:1395	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	12	21	theme	silicocarnotite	2158:2172	arg1	formation					2145:2153	the formation	2141:2153	the formation of silicocarnotite	2141:2172	The results indicate that the addition of Si into biphasic fibers, leading to the formation of silicocarnotite, makes silicocarnotite a potential candidate for the bioactive reinforcement of composite scaffolds for bone tissue engineering.
32438355	5	22	theme	new	848:850	arg1	phase					852:856	a new phase	846:856	a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase	846:917	However, the addition of Si to fibers synthesized within 8 d under reflux conditions produced biphasic fibers with 1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase.
32438355	0	23	theme	osteogenic	15:24	arg1	chitosan/alginate					26:42	osteogenic chitosan/alginate	15:42	osteogenic chitosan/alginate	15:42	Development of osteogenic chitosan/alginate scaffolds reinforced with silicocarnotite containing apatitic fibers.
32438355	9	24	theme	SBF	1429:1431	arg1	testing					1433:1439	SBF testing	1429:1439	SBF testing	1429:1439	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	3	25	theme	wt	579:580	arg1	hydroxyapatite					556:569	hydroxyapatite	556:569	hydroxyapatite (∼93-96 wt%)	556:582	Fibers produced with no Si incorporation using two different reaction times of 4 d and 8 d comprised two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP).
32438355	3	25	theme	wt	579:580	arg1	%					581:581	∼93-96 wt%	572:581	∼93-96 wt%	572:581	Fibers produced with no Si incorporation using two different reaction times of 4 d and 8 d comprised two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP).
32438355	1	26	theme	calcium	193:199	arg1	fibers					211:216	biphasic calcium phosphate fibers	184:216	biphasic calcium phosphate fibers containing silicon (Si)	184:240	Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si) were prepared using the freeze-drying method.
32438355	8	27	theme	interconnected	1237:1250	arg1	pores					1252:1256	the interconnected pores	1233:1256	the interconnected pores	1233:1256	The scaffolds exhibited favorable microstructures with a high porosity (66-88%) and the interconnected pores varied in size between 40 and 250 µm.
32438355	7	28	theme	fiber	1105:1109	arg1	contents					1111:1118	different fiber contents	1095:1118	different fiber contents	1095:1118	The physicochemical, mechanical, and biological properties of composite scaffolds fabricated by adding different fiber contents and types were investigated.
32438355	5	29	theme	wt	882:883	arg1	silicocarnotite					861:875	silicocarnotite	861:875	silicocarnotite (∼94 wt%) associated with the β-TCP phase	861:917	However, the addition of Si to fibers synthesized within 8 d under reflux conditions produced biphasic fibers with 1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase.
32438355	5	29	theme	wt	882:883	arg1	%					884:884	∼94 wt%	878:884	∼94 wt%	878:884	However, the addition of Si to fibers synthesized within 8 d under reflux conditions produced biphasic fibers with 1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase.
32438355	12	30	theme	biphasic	2113:2120	arg1	fibers					2122:2127	biphasic fibers	2113:2127	biphasic fibers	2113:2127	The results indicate that the addition of Si into biphasic fibers, leading to the formation of silicocarnotite, makes silicocarnotite a potential candidate for the bioactive reinforcement of composite scaffolds for bone tissue engineering.
32438355	9	31	dep	in	1401:1402	arg1	vitro					1404:1408	vitro	1404:1408	vitro	1404:1408	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	11	32	theme	Composite	1808:1816	arg1	scaffolds					1818:1826	Composite scaffolds	1808:1826	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d	1808:1877	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d were superior in terms of their mechanical properties and achieved a compressive strength and modulus of 272 kPa and 4.9 MPa, respectively, which is 400% greater than CH-AL scaffolds.
32438355	9	33	theme	apatite	1469:1475	arg1	layer					1477:1481	the apatite layer	1465:1481	the apatite layer	1465:1481	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	1	34	theme	composite	121:129	arg1	scaffolds					131:139	Porous composite scaffolds	114:139	Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si)	114:240	Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si) were prepared using the freeze-drying method.
32438355	3	35	theme	β-tricalcium	588:599	arg1	phosphate					601:609	β-tricalcium phosphate	588:609	β-tricalcium phosphate (β-TCP)	588:617	Fibers produced with no Si incorporation using two different reaction times of 4 d and 8 d comprised two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP).
32438355	3	35	theme	β-tricalcium	588:599	arg1	β-TCP					612:616	β-TCP	612:616	β-TCP	612:616	Fibers produced with no Si incorporation using two different reaction times of 4 d and 8 d comprised two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP).
32438355	7	36	theme	composite	1054:1062	arg1	scaffolds					1064:1072	composite scaffolds	1054:1072	composite scaffolds fabricated by adding different fiber contents and types	1054:1128	The physicochemical, mechanical, and biological properties of composite scaffolds fabricated by adding different fiber contents and types were investigated.
32438355	10	37	theme	silicocarnotite	1663:1677	arg1	fibers					1679:1684	silicocarnotite fibers	1663:1684	silicocarnotite fibers	1663:1684	Scaffolds reinforced with silicocarnotite fibers also exhibited better mechanical properties and water uptake, compared to ones containing incorporated fibers made of Si.
32438355	1	38	contain	containing	218:227	arg2	Si					238:239	Si	238:239	Si	238:239	Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si) were prepared using the freeze-drying method.
32438355	1	38	contain	containing	218:227	arg2	silicon					229:235	silicon	229:235	silicon (Si)	229:240	Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si) were prepared using the freeze-drying method.
32438355	1	38	contain	containing	218:227	arg1	fibers					211:216	biphasic calcium phosphate fibers	184:216	biphasic calcium phosphate fibers containing silicon (Si)	184:240	Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si) were prepared using the freeze-drying method.
32438355	3	39	theme	Si	465:466	arg1	incorporation					468:480	no Si incorporation	462:480	no Si incorporation using two different reaction times of 4 d and 8 d	462:530	Fibers produced with no Si incorporation using two different reaction times of 4 d and 8 d comprised two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP).
32438355	1	40	theme	phosphate	201:209	arg1	fibers					211:216	biphasic calcium phosphate fibers	184:216	biphasic calcium phosphate fibers containing silicon (Si)	184:240	Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si) were prepared using the freeze-drying method.
32438355	5	41	theme	Si	726:727	arg1	addition					714:721	the addition	710:721	the addition of Si to fibers synthesized within 8 d under reflux conditions	710:784	However, the addition of Si to fibers synthesized within 8 d under reflux conditions produced biphasic fibers with 1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase.
32438355	11	42	theme	CH-AL	2046:2050	arg1	scaffolds					2052:2060	CH-AL scaffolds	2046:2060	CH-AL scaffolds	2046:2060	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d were superior in terms of their mechanical properties and achieved a compressive strength and modulus of 272 kPa and 4.9 MPa, respectively, which is 400% greater than CH-AL scaffolds.
32438355	12	43	theme	tissue	2283:2288	arg1	engineering					2290:2300	bone tissue engineering	2278:2300	bone tissue engineering	2278:2300	The results indicate that the addition of Si into biphasic fibers, leading to the formation of silicocarnotite, makes silicocarnotite a potential candidate for the bioactive reinforcement of composite scaffolds for bone tissue engineering.
32438355	1	44	theme	chitosan-alginate	144:160	arg1	scaffolds					131:139	Porous composite scaffolds	114:139	Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si)	114:240	Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si) were prepared using the freeze-drying method.
32438355	0	45	dep	scaffolds	44:52	arg1	reinforced					54:63	reinforced	54:63	scaffolds reinforced with silicocarnotite containing apatitic fibers	44:111	Development of osteogenic chitosan/alginate scaffolds reinforced with silicocarnotite containing apatitic fibers.
32438355	3	46	theme	phosphate	601:609	arg1	phases					546:551	two phases	542:551	two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP)	542:617	Fibers produced with no Si incorporation using two different reaction times of 4 d and 8 d comprised two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP).
32438355	2	47	theme	reaction	371:378	arg1	times					380:384	reaction times	371:384	reaction times	371:384	The fibers were synthesized using a homogenous precipitation method with differing reaction times and were characterized by XRD, FTIR, SEM, and ICP-OES.
32438355	9	48	from	improvement	1354:1364	arg1	properties					1386:1395	their mechanical properties	1369:1395	their mechanical properties	1369:1395	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	5	49	theme	%	822:822	arg1	Si					824:825	1.9 wt% Si	816:825	1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase	816:917	However, the addition of Si to fibers synthesized within 8 d under reflux conditions produced biphasic fibers with 1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase.
32438355	12	50	theme	composite	2254:2262	arg1	scaffolds					2264:2272	composite scaffolds	2254:2272	composite scaffolds for bone tissue engineering	2254:2300	The results indicate that the addition of Si into biphasic fibers, leading to the formation of silicocarnotite, makes silicocarnotite a potential candidate for the bioactive reinforcement of composite scaffolds for bone tissue engineering.
32438355	10	51	theme	incorporated	1776:1787	arg1	fibers					1789:1794	incorporated fibers	1776:1794	incorporated fibers made of Si	1776:1805	Scaffolds reinforced with silicocarnotite fibers also exhibited better mechanical properties and water uptake, compared to ones containing incorporated fibers made of Si.
32438355	5	52	theme	β-TCP	907:911	arg1	phase					913:917	the β-TCP phase	903:917	the β-TCP phase	903:917	However, the addition of Si to fibers synthesized within 8 d under reflux conditions produced biphasic fibers with 1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase.
32438355	11	53	dep	strength	1960:1967	arg1	a					1946:1946	a	1946:1946	a	1946:1946	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d were superior in terms of their mechanical properties and achieved a compressive strength and modulus of 272 kPa and 4.9 MPa, respectively, which is 400% greater than CH-AL scaffolds.
32438355	9	54	theme	MG63	1565:1568	arg1	cells					1570:1574	MG63 cells	1565:1574	MG63 cells	1565:1574	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	8	55	with	microstructures	1183:1197	arg1	porosity					1211:1218	a high porosity	1204:1218	a high porosity (66-88%)	1204:1227	The scaffolds exhibited favorable microstructures with a high porosity (66-88%) and the interconnected pores varied in size between 40 and 250 µm.
32438355	8	55	with	microstructures	1183:1197	arg1	%					1226:1226	66-88%	1221:1226	66-88%	1221:1226	The scaffolds exhibited favorable microstructures with a high porosity (66-88%) and the interconnected pores varied in size between 40 and 250 µm.
32438355	3	56	theme	d	530:530	arg1	times					511:515	two different reaction times	488:515	two different reaction times of 4 d and 8 d	488:530	Fibers produced with no Si incorporation using two different reaction times of 4 d and 8 d comprised two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP).
32438355	5	57	theme	biphasic	795:802	arg1	fibers					804:809	biphasic fibers	795:809	biphasic fibers with 1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase	795:917	However, the addition of Si to fibers synthesized within 8 d under reflux conditions produced biphasic fibers with 1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase.
32438355	9	58	from	bioactivity	1410:1420	arg1	properties					1386:1395	their mechanical properties	1369:1395	their mechanical properties	1369:1395	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	9	59	contain	containing	1306:1315	arg2	silicocarnotite					1317:1331	silicocarnotite	1317:1331	silicocarnotite	1317:1331	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	9	59	contain	containing	1306:1315	arg1	Scaffolds					1296:1304	Scaffolds	1296:1304	Scaffolds containing silicocarnotite	1296:1331	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	2	60	theme	precipitation	335:347	arg1	method					349:354	a homogenous precipitation method	322:354	a homogenous precipitation method	322:354	The fibers were synthesized using a homogenous precipitation method with differing reaction times and were characterized by XRD, FTIR, SEM, and ICP-OES.
32438355	9	61	theme	MTT	1595:1597	arg1	assay					1599:1603	MTT assay	1595:1603	MTT assay	1595:1603	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	12	62	theme	potential	2199:2207	arg1	candidate					2209:2217	a potential candidate	2197:2217	a potential candidate for the bioactive reinforcement of composite scaffolds for bone tissue engineering	2197:2300	The results indicate that the addition of Si into biphasic fibers, leading to the formation of silicocarnotite, makes silicocarnotite a potential candidate for the bioactive reinforcement of composite scaffolds for bone tissue engineering.
32438355	11	63	theme	compressive	1948:1958	arg1	strength					1960:1967	compressive strength	1948:1967	compressive strength	1948:1967	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d were superior in terms of their mechanical properties and achieved a compressive strength and modulus of 272 kPa and 4.9 MPa, respectively, which is 400% greater than CH-AL scaffolds.
32438355	11	64	theme	%	1847:1847	arg1	fibers					1849:1854	50 wt% fibers	1842:1854	50 wt% fibers precipitated after 8 d	1842:1877	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d were superior in terms of their mechanical properties and achieved a compressive strength and modulus of 272 kPa and 4.9 MPa, respectively, which is 400% greater than CH-AL scaffolds.
32438355	9	65	theme	in	1401:1402	arg1	bioactivity					1410:1420	in vitro bioactivity	1401:1420	in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS)	1401:1506	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	11	66	theme	kPa	1988:1990	arg1	strength					1960:1967	compressive strength	1948:1967	compressive strength	1948:1967	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d were superior in terms of their mechanical properties and achieved a compressive strength and modulus of 272 kPa and 4.9 MPa, respectively, which is 400% greater than CH-AL scaffolds.
32438355	11	66	theme	kPa	1988:1990	arg1	MPa					2000:2002	4.9 MPa	1996:2002	4.9 MPa	1996:2002	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d were superior in terms of their mechanical properties and achieved a compressive strength and modulus of 272 kPa and 4.9 MPa, respectively, which is 400% greater than CH-AL scaffolds.
32438355	11	66	theme	kPa	1988:1990	arg1	modulus					1973:1979	modulus	1973:1979	modulus	1973:1979	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d were superior in terms of their mechanical properties and achieved a compressive strength and modulus of 272 kPa and 4.9 MPa, respectively, which is 400% greater than CH-AL scaffolds.
32438355	11	67	theme	mechanical	1911:1920	arg1	properties					1922:1931	their mechanical properties	1905:1931	their mechanical properties	1905:1931	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d were superior in terms of their mechanical properties and achieved a compressive strength and modulus of 272 kPa and 4.9 MPa, respectively, which is 400% greater than CH-AL scaffolds.
32438355	6	68	theme	whisker-like	924:935	arg1	fibers					937:942	The whisker-like fibers	920:942	The whisker-like fibers	920:942	The whisker-like fibers were 10-200 µm in length and 0.2-5 µm in width.
32438355	6	68	theme	whisker-like	924:935	arg1	µm					956:957	10-200 µm	949:957	10-200 µm	949:957	The whisker-like fibers were 10-200 µm in length and 0.2-5 µm in width.
32438355	3	69	theme	different	492:500	arg1	times					511:515	two different reaction times	488:515	two different reaction times of 4 d and 8 d	488:530	Fibers produced with no Si incorporation using two different reaction times of 4 d and 8 d comprised two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP).
32438355	0	70	theme	apatitic	97:104	arg1	fibers					106:111	apatitic fibers	97:111	apatitic fibers	97:111	Development of osteogenic chitosan/alginate scaffolds reinforced with silicocarnotite containing apatitic fibers.
32438355	10	71	theme	water	1734:1738	arg1	uptake					1740:1745	water uptake	1734:1745	water uptake	1734:1745	Scaffolds reinforced with silicocarnotite fibers also exhibited better mechanical properties and water uptake, compared to ones containing incorporated fibers made of Si.
32438355	5	72	theme	wt	820:821	arg1	Si					824:825	1.9 wt% Si	816:825	1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase	816:917	However, the addition of Si to fibers synthesized within 8 d under reflux conditions produced biphasic fibers with 1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase.
32438355	1	73	theme	biphasic	184:191	arg1	fibers					211:216	biphasic calcium phosphate fibers	184:216	biphasic calcium phosphate fibers containing silicon (Si)	184:240	Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si) were prepared using the freeze-drying method.
32438355	4	74	theme	wt	662:663	arg1	Si					669:670	Si	669:670	Si	669:670	No new phases were observed by adding 0.8 wt% of Si during 4 d of precipitation.
32438355	4	74	theme	wt	662:663	arg1	%					664:664	0.8 wt%	658:664	0.8 wt% of Si	658:670	No new phases were observed by adding 0.8 wt% of Si during 4 d of precipitation.
32438355	7	75	theme	different	1095:1103	arg1	contents					1111:1118	different fiber contents	1095:1118	different fiber contents	1095:1118	The physicochemical, mechanical, and biological properties of composite scaffolds fabricated by adding different fiber contents and types were investigated.
32438355	2	76	theme	homogenous	324:333	arg1	method					349:354	a homogenous precipitation method	322:354	a homogenous precipitation method	322:354	The fibers were synthesized using a homogenous precipitation method with differing reaction times and were characterized by XRD, FTIR, SEM, and ICP-OES.
32438355	9	77	theme	mechanical	1375:1384	arg1	properties					1386:1395	their mechanical properties	1369:1395	their mechanical properties	1369:1395	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	9	78	from	mineralization	1534:1547	arg1	properties					1386:1395	their mechanical properties	1369:1395	their mechanical properties	1369:1395	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	6	79	theme	0.2-5	973:977	arg1	µm					979:980	0.2-5 µm	973:980	0.2-5 µm	973:980	The whisker-like fibers were 10-200 µm in length and 0.2-5 µm in width.
32438355	12	80	theme	Si	2105:2106	arg1	addition					2093:2100	the addition	2089:2100	the addition	2089:2100	The results indicate that the addition of Si into biphasic fibers, leading to the formation of silicocarnotite, makes silicocarnotite a potential candidate for the bioactive reinforcement of composite scaffolds for bone tissue engineering.
32438355	7	81	theme	scaffolds	1064:1072	arg1	properties					1040:1049	The physicochemical, mechanical, and biological properties	992:1049	The physicochemical, mechanical, and biological properties of composite scaffolds fabricated by adding different fiber contents and types	992:1128	The physicochemical, mechanical, and biological properties of composite scaffolds fabricated by adding different fiber contents and types were investigated.
32438355	1	82	theme	Porous	114:119	arg1	scaffolds					131:139	Porous composite scaffolds	114:139	Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si)	114:240	Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si) were prepared using the freeze-drying method.
32438355	9	83	from	proliferation	1519:1531	arg1	properties					1386:1395	their mechanical properties	1369:1395	their mechanical properties	1369:1395	Scaffolds containing silicocarnotite showed a significant improvement in their mechanical properties and in vitro bioactivity (using SBF testing and characterization of the apatite layer by ATR-FTIR and SEM/EDS) as well as proliferation, mineralization and adhesion of MG63 cells, when evaluated by MTT assay, alkaline phosphatase, and SEM.
32438355	0	84	theme	chitosan/alginate	26:42	arg1	Development					0:10	Development	0:10	Development of osteogenic chitosan/alginate	0:42	Development of osteogenic chitosan/alginate scaffolds reinforced with silicocarnotite containing apatitic fibers.
32438355	5	85	theme	silicocarnotite	861:875	arg1	phase					852:856	a new phase	846:856	a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase	846:917	However, the addition of Si to fibers synthesized within 8 d under reflux conditions produced biphasic fibers with 1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase.
32438355	4	86	theme	precipitation	686:698	arg1	d					681:681	4 d	679:681	4 d of precipitation	679:698	No new phases were observed by adding 0.8 wt% of Si during 4 d of precipitation.
32438355	11	87	theme	wt	1845:1846	arg1	fibers					1849:1854	50 wt% fibers	1842:1854	50 wt% fibers precipitated after 8 d	1842:1877	Composite scaffolds reinforced by 50 wt% fibers precipitated after 8 d were superior in terms of their mechanical properties and achieved a compressive strength and modulus of 272 kPa and 4.9 MPa, respectively, which is 400% greater than CH-AL scaffolds.
32438355	7	88	theme	biological	1029:1038	arg1	properties					1040:1049	The physicochemical, mechanical, and biological properties	992:1049	The physicochemical, mechanical, and biological properties of composite scaffolds fabricated by adding different fiber contents and types	992:1128	The physicochemical, mechanical, and biological properties of composite scaffolds fabricated by adding different fiber contents and types were investigated.
32438355	12	89	theme	scaffolds	2264:2272	arg1	reinforcement					2237:2249	the bioactive reinforcement	2223:2249	the bioactive reinforcement of composite scaffolds for bone tissue engineering	2223:2300	The results indicate that the addition of Si into biphasic fibers, leading to the formation of silicocarnotite, makes silicocarnotite a potential candidate for the bioactive reinforcement of composite scaffolds for bone tissue engineering.
32438355	5	90	with	fibers	804:809	arg1	Si					824:825	1.9 wt% Si	816:825	1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase	816:917	However, the addition of Si to fibers synthesized within 8 d under reflux conditions produced biphasic fibers with 1.9 wt% Si which consisted of a new phase of silicocarnotite (∼94 wt%) associated with the β-TCP phase.
32438355	3	91	theme	reaction	502:509	arg1	times					511:515	two different reaction times	488:515	two different reaction times of 4 d and 8 d	488:530	Fibers produced with no Si incorporation using two different reaction times of 4 d and 8 d comprised two phases of hydroxyapatite (∼93-96 wt%) and β-tricalcium phosphate (β-TCP).
32438355	10	92	contain	containing	1765:1774	arg1	ones					1760:1763	ones	1760:1763	ones containing incorporated fibers made of Si	1760:1805	Scaffolds reinforced with silicocarnotite fibers also exhibited better mechanical properties and water uptake, compared to ones containing incorporated fibers made of Si.
32438355	10	92	contain	containing	1765:1774	arg2	fibers					1789:1794	incorporated fibers	1776:1794	incorporated fibers made of Si	1776:1805	Scaffolds reinforced with silicocarnotite fibers also exhibited better mechanical properties and water uptake, compared to ones containing incorporated fibers made of Si.
32438355	12	93	theme	bone	2278:2281	arg1	engineering					2290:2300	bone tissue engineering	2278:2300	bone tissue engineering	2278:2300	The results indicate that the addition of Si into biphasic fibers, leading to the formation of silicocarnotite, makes silicocarnotite a potential candidate for the bioactive reinforcement of composite scaffolds for bone tissue engineering.
32438355	0	94	contain	containing	86:95	arg2	fibers					106:111	apatitic fibers	97:111	apatitic fibers	97:111	Development of osteogenic chitosan/alginate scaffolds reinforced with silicocarnotite containing apatitic fibers.
32438355	0	94	contain	containing	86:95	arg1	silicocarnotite					70:84	silicocarnotite	70:84	silicocarnotite containing apatitic fibers	70:111	Development of osteogenic chitosan/alginate scaffolds reinforced with silicocarnotite containing apatitic fibers.
32438355	1	95	theme	freeze-drying	266:278	arg1	method					280:285	the freeze-drying method	262:285	the freeze-drying method	262:285	Porous composite scaffolds of chitosan-alginate (CH-AL) reinforced by biphasic calcium phosphate fibers containing silicon (Si) were prepared using the freeze-drying method.
34572560	5	0	attach	presence	856:863	arg2	peaks					877:881	carbonyl peaks	868:881	carbonyl peaks	868:881	FTIR spectra of the modified CNF revealed the presence of carbonyl peaks at 1720 cm-1, suggesting that the esterification reaction was successful.
34572560	5	0	attach	presence	856:863	arg1	cm-1					891:894	1720 cm-1	886:894	1720 cm-1	886:894	FTIR spectra of the modified CNF revealed the presence of carbonyl peaks at 1720 cm-1, suggesting that the esterification reaction was successful.
34572560	7	1	theme	water	1169:1173	arg1	vapor					1175:1179	water vapor and oxygen permeability	1169:1203	vapor	1175:1179	Additionally, films made from modified CNF had lower water absorption, as well as water vapor and oxygen permeability, relative to their counterparts with unmodified CNFs.
34572560	1	2	theme	catalyzed	235:243	arg1	acid					252:255	catalyzed lactic acid	235:255	catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst	235:316	In this study, cellulose nanofibrils (CNFs) were modified by catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst.
34572560	9	3	contain	containing	1523:1532	arg1	composites					1512:1521	composites	1512:1521	composites containing ungrafted CNF	1512:1546	However, the addition of lactic acid-grafted CNF to PLA improved the water vapor permeability relative to composites containing ungrafted CNF.
34572560	9	3	contain	containing	1523:1532	arg2	CNF					1544:1546	ungrafted CNF	1534:1546	ungrafted CNF	1534:1546	However, the addition of lactic acid-grafted CNF to PLA improved the water vapor permeability relative to composites containing ungrafted CNF.
34572560	3	4	theme	lactic	524:529	arg1	poly					519:522	poly	519:522	poly(lactic acid) (PLA)	519:541	Ungrafted and lactic acid-grafted CNF was also compounded with poly(lactic acid) (PLA) to produce composites.
34572560	3	4	theme	lactic	524:529	arg1	acid					531:534	lactic acid	524:534	lactic acid	524:534	Ungrafted and lactic acid-grafted CNF was also compounded with poly(lactic acid) (PLA) to produce composites.
34572560	1	5	theme	acid	252:255	arg1	esterification					257:270	catalyzed lactic acid esterification	235:270	catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst	235:316	In this study, cellulose nanofibrils (CNFs) were modified by catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst.
34572560	10	6	theme	CNFs	1688:1691	arg1	chemistry					1675:1683	the surface chemistry	1663:1683	the surface chemistry of CNFs	1663:1691	Therefore, the esterification of CNFs in an aqueous medium may provide an environmentally benign way of modifying the surface chemistry of CNFs to improve the barrier properties of CNF films and PLA/CNF composites.
34572560	7	7	with	counterparts	1224:1235	arg1	CNFs					1253:1256	unmodified CNFs	1242:1256	unmodified CNFs	1242:1256	Additionally, films made from modified CNF had lower water absorption, as well as water vapor and oxygen permeability, relative to their counterparts with unmodified CNFs.
34572560	10	8	theme	barrier	1708:1714	arg1	properties					1716:1725	the barrier properties	1704:1725	the barrier properties of CNF films and PLA/CNF composites	1704:1761	Therefore, the esterification of CNFs in an aqueous medium may provide an environmentally benign way of modifying the surface chemistry of CNFs to improve the barrier properties of CNF films and PLA/CNF composites.
34572560	1	9	theme	cellulose	189:197	arg1	CNFs					212:215	CNFs	212:215	CNFs	212:215	In this study, cellulose nanofibrils (CNFs) were modified by catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst.
34572560	1	9	theme	cellulose	189:197	arg1	nanofibrils					199:209	cellulose nanofibrils	189:209	cellulose nanofibrils (CNFs)	189:216	In this study, cellulose nanofibrils (CNFs) were modified by catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst.
34572560	4	10	theme	barrier	600:606	arg1	properties					608:617	barrier properties	600:617	barrier properties	600:617	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	0	11	theme	Nanofibril-Poly	133:147	arg1	Composites					162:171	Cellulose Nanofibril-Poly(lactic acid) Composites	123:171	Cellulose Nanofibril-Poly(lactic acid) Composites	123:171	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	10	12	theme	PLA/CNF	1744:1750	arg1	composites					1752:1761	PLA/CNF composites	1744:1761	PLA/CNF composites	1744:1761	Therefore, the esterification of CNFs in an aqueous medium may provide an environmentally benign way of modifying the surface chemistry of CNFs to improve the barrier properties of CNF films and PLA/CNF composites.
34572560	4	13	theme	CNF	673:675	arg1	films					677:681	lactic acid-grafted CNF films	653:681	lactic acid-grafted CNF films	653:681	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	0	14	theme	lactic	149:154	arg1	Nanofibril-Poly					133:147	Cellulose Nanofibril-Poly	123:147	Cellulose Nanofibril-Poly(lactic acid) Composites	123:171	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	0	14	theme	lactic	149:154	arg1	acid					156:159	lactic acid	149:159	lactic acid	149:159	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	10	15	theme	films	1734:1738	arg1	properties					1716:1725	the barrier properties	1704:1725	the barrier properties of CNF films and PLA/CNF composites	1704:1761	Therefore, the esterification of CNFs in an aqueous medium may provide an environmentally benign way of modifying the surface chemistry of CNFs to improve the barrier properties of CNF films and PLA/CNF composites.
34572560	9	16	theme	lactic	1431:1436	arg1	CNF					1451:1453	lactic acid-grafted CNF	1431:1453	lactic acid-grafted CNF	1431:1453	However, the addition of lactic acid-grafted CNF to PLA improved the water vapor permeability relative to composites containing ungrafted CNF.
34572560	9	17	theme	CNF	1451:1453	arg1	addition					1419:1426	the addition	1415:1426	the addition of lactic acid-grafted CNF to PLA	1415:1460	However, the addition of lactic acid-grafted CNF to PLA improved the water vapor permeability relative to composites containing ungrafted CNF.
34572560	5	18	theme	carbonyl	868:875	arg1	peaks					877:881	carbonyl peaks	868:881	carbonyl peaks	868:881	FTIR spectra of the modified CNF revealed the presence of carbonyl peaks at 1720 cm-1, suggesting that the esterification reaction was successful.
34572560	0	19	theme	Nanofibrils	59:69	arg1	Modification					33:44	Lactic Acid Surface Modification	13:44	Lactic Acid Surface Modification of Cellulose Nanofibrils	13:69	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	5	20	theme	CNF	839:841	arg1	spectra					815:821	FTIR spectra	810:821	FTIR spectra of the modified CNF	810:841	FTIR spectra of the modified CNF revealed the presence of carbonyl peaks at 1720 cm-1, suggesting that the esterification reaction was successful.
34572560	4	21	theme	lactic	653:658	arg1	films					677:681	lactic acid-grafted CNF films	653:681	lactic acid-grafted CNF films	653:681	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	0	22	from	Influence	0:8	arg1	Properties					78:87	the Properties	74:87	the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites	74:171	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	9	23	theme	vapor	1481:1485	arg1	permeability					1487:1498	the water vapor permeability	1471:1498	the water vapor permeability relative to composites containing ungrafted CNF	1471:1546	However, the addition of lactic acid-grafted CNF to PLA improved the water vapor permeability relative to composites containing ungrafted CNF.
34572560	5	24	theme	peaks	877:881	arg1	presence					856:863	the presence	852:863	the presence of carbonyl peaks at 1720 cm-1	852:894	FTIR spectra of the modified CNF revealed the presence of carbonyl peaks at 1720 cm-1, suggesting that the esterification reaction was successful.
34572560	8	25	theme	composites	1296:1305	arg1	properties					1274:1283	The mechanical properties	1259:1283	The mechanical properties of PLA/CNF composites made from lactic acid-grafted CNFs	1259:1340	The mechanical properties of PLA/CNF composites made from lactic acid-grafted CNFs did not significantly change with respect to the ungrafted CNF.
34572560	0	26	theme	Nanofibril	102:111	arg1	Films					113:117	Cellulose Nanofibril Films	92:117	Cellulose Nanofibril Films	92:117	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	5	27	theme	esterification	917:930	arg1	successful					945:954	successful	945:954	successful	945:954	FTIR spectra of the modified CNF revealed the presence of carbonyl peaks at 1720 cm-1, suggesting that the esterification reaction was successful.
34572560	5	27	theme	esterification	917:930	arg1	reaction					932:939	the esterification reaction	913:939	the esterification reaction	913:939	FTIR spectra of the modified CNF revealed the presence of carbonyl peaks at 1720 cm-1, suggesting that the esterification reaction was successful.
34572560	4	28	theme	PLA/CNF	688:694	arg1	composites					696:705	PLA/CNF composites	688:705	PLA/CNF composites	688:705	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	2	29	theme	lactic	355:360	arg1	CNF					376:378	unmodified and lactic acid-modified CNF	340:378	unmodified and lactic acid-modified CNF without a polymer matrix	340:403	Films were made from unmodified and lactic acid-modified CNF without a polymer matrix to evaluate the effectiveness of the modification.
34572560	8	30	theme	acid-grafted	1324:1335	arg1	CNFs					1337:1340	lactic acid-grafted CNFs	1317:1340	lactic acid-grafted CNFs	1317:1340	The mechanical properties of PLA/CNF composites made from lactic acid-grafted CNFs did not significantly change with respect to the ungrafted CNF.
34572560	0	31	theme	Lactic	13:18	arg1	Modification					33:44	Lactic Acid Surface Modification	13:44	Lactic Acid Surface Modification of Cellulose Nanofibrils	13:69	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	9	32	theme	ungrafted	1534:1542	arg1	CNF					1544:1546	ungrafted CNF	1534:1546	ungrafted CNF	1534:1546	However, the addition of lactic acid-grafted CNF to PLA improved the water vapor permeability relative to composites containing ungrafted CNF.
34572560	7	33	theme	unmodified	1242:1251	arg1	CNFs					1253:1256	unmodified CNFs	1242:1256	unmodified CNFs	1242:1256	Additionally, films made from modified CNF had lower water absorption, as well as water vapor and oxygen permeability, relative to their counterparts with unmodified CNFs.
34572560	0	34	mod	Modification	33:44	arg1	Nanofibrils					59:69	Cellulose Nanofibrils	49:69	Cellulose Nanofibrils	49:69	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	0	34	mod	Modification	33:44	arg3	Surface					25:31	Lactic Acid Surface Modification	13:44	Lactic Acid Surface Modification of Cellulose Nanofibrils	13:69	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	0	34	mod	Modification	33:44	arg3	Acid					20:23	Lactic Acid Surface Modification	13:44	Lactic Acid Surface Modification of Cellulose Nanofibrils	13:69	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	0	35	theme	Surface	25:31	arg1	Modification					33:44	Lactic Acid Surface Modification	13:44	Lactic Acid Surface Modification of Cellulose Nanofibrils	13:69	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	7	36	contain	had	1130:1132	arg1	films					1101:1105	films	1101:1105	films made from modified CNF	1101:1128	Additionally, films made from modified CNF had lower water absorption, as well as water vapor and oxygen permeability, relative to their counterparts with unmodified CNFs.
34572560	7	36	contain	had	1130:1132	arg2	absorption					1146:1155	lower water absorption	1134:1155	lower water absorption	1134:1155	Additionally, films made from modified CNF had lower water absorption, as well as water vapor and oxygen permeability, relative to their counterparts with unmodified CNFs.
34572560	7	36	contain	had	1130:1132	arg2	vapor					1175:1179	water vapor and oxygen permeability	1169:1203	vapor	1175:1179	Additionally, films made from modified CNF had lower water absorption, as well as water vapor and oxygen permeability, relative to their counterparts with unmodified CNFs.
34572560	3	37	theme	lactic	470:475	arg1	CNF					490:492	lactic acid-grafted CNF	470:492	lactic acid-grafted CNF	470:492	Ungrafted and lactic acid-grafted CNF was also compounded with poly(lactic acid) (PLA) to produce composites.
34572560	4	38	theme	acid	741:744	arg1	modification					746:757	lactic acid modification	734:757	lactic acid modification	734:757	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	6	39	theme	CNF	973:975	arg1	Modification					957:968	Modification	957:968	Modification of CNF with LA	957:983	Modification of CNF with LA improved the tensile modulus of the produced films but the tensile strength and elongation decreased.
34572560	2	40	theme	unmodified	340:349	arg1	CNF					376:378	unmodified and lactic acid-modified CNF	340:378	unmodified and lactic acid-modified CNF without a polymer matrix	340:403	Films were made from unmodified and lactic acid-modified CNF without a polymer matrix to evaluate the effectiveness of the modification.
34572560	7	41	theme	oxygen	1185:1190	arg1	permeability					1192:1203	water vapor and oxygen permeability	1169:1203	permeability	1192:1203	Additionally, films made from modified CNF had lower water absorption, as well as water vapor and oxygen permeability, relative to their counterparts with unmodified CNFs.
34572560	10	42	theme	surface	1667:1673	arg1	chemistry					1675:1683	the surface chemistry	1663:1683	the surface chemistry of CNFs	1663:1691	Therefore, the esterification of CNFs in an aqueous medium may provide an environmentally benign way of modifying the surface chemistry of CNFs to improve the barrier properties of CNF films and PLA/CNF composites.
34572560	6	43	theme	films	1030:1034	arg1	modulus					1006:1012	the tensile modulus	994:1012	the tensile modulus of the produced films	994:1034	Modification of CNF with LA improved the tensile modulus of the produced films but the tensile strength and elongation decreased.
34572560	1	44	theme	lactic	245:250	arg1	acid					252:255	catalyzed lactic acid	235:255	catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst	235:316	In this study, cellulose nanofibrils (CNFs) were modified by catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst.
34572560	10	45	from	esterification	1564:1577	arg1	medium					1601:1606	an aqueous medium	1590:1606	an aqueous medium	1590:1606	Therefore, the esterification of CNFs in an aqueous medium may provide an environmentally benign way of modifying the surface chemistry of CNFs to improve the barrier properties of CNF films and PLA/CNF composites.
34572560	1	46	with	medium	286:291	arg1	SnCl2					298:302	SnCl2	298:302	SnCl2 as a catalyst	298:316	In this study, cellulose nanofibrils (CNFs) were modified by catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst.
34572560	8	47	theme	mechanical	1263:1272	arg1	properties					1274:1283	The mechanical properties	1259:1283	The mechanical properties of PLA/CNF composites made from lactic acid-grafted CNFs	1259:1340	The mechanical properties of PLA/CNF composites made from lactic acid-grafted CNFs did not significantly change with respect to the ungrafted CNF.
34572560	5	48	theme	FTIR	810:813	arg1	spectra					815:821	FTIR spectra	810:821	FTIR spectra of the modified CNF	810:841	FTIR spectra of the modified CNF revealed the presence of carbonyl peaks at 1720 cm-1, suggesting that the esterification reaction was successful.
34572560	4	49	theme	films	784:788	arg1	nanocomposites					794:807	nanocomposites	794:807	nanocomposites	794:807	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	4	49	theme	films	784:788	arg1	properties					766:775	the properties	762:775	the properties of the films	762:788	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	4	49	theme	films	784:788	arg1	films					784:788	the films	780:788	the films	780:788	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	1	50	from	esterification	257:270	arg1	medium					286:291	an aqueous medium	275:291	an aqueous medium with SnCl2 as a catalyst	275:316	In this study, cellulose nanofibrils (CNFs) were modified by catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst.
34572560	10	51	theme	CNF	1730:1732	arg1	films					1734:1738	CNF films	1730:1738	CNF films	1730:1738	Therefore, the esterification of CNFs in an aqueous medium may provide an environmentally benign way of modifying the surface chemistry of CNFs to improve the barrier properties of CNF films and PLA/CNF composites.
34572560	1	52	mod	modified	223:230	arg3	esterification					257:270	catalyzed lactic acid esterification	235:270	catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst	235:316	In this study, cellulose nanofibrils (CNFs) were modified by catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst.
34572560	1	52	mod	modified	223:230	arg1	CNFs					212:215	CNFs	212:215	CNFs	212:215	In this study, cellulose nanofibrils (CNFs) were modified by catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst.
34572560	1	52	mod	modified	223:230	arg1	nanofibrils					199:209	cellulose nanofibrils	189:209	cellulose nanofibrils (CNFs)	189:216	In this study, cellulose nanofibrils (CNFs) were modified by catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst.
34572560	0	53	theme	Cellulose	123:131	arg1	Nanofibril-Poly					133:147	Cellulose Nanofibril-Poly	123:147	Cellulose Nanofibril-Poly(lactic acid) Composites	123:171	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	0	53	theme	Cellulose	123:131	arg1	acid					156:159	lactic acid	149:159	lactic acid	149:159	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	8	54	theme	ungrafted	1391:1399	arg1	CNF					1401:1403	the ungrafted CNF	1387:1403	the ungrafted CNF	1387:1403	The mechanical properties of PLA/CNF composites made from lactic acid-grafted CNFs did not significantly change with respect to the ungrafted CNF.
34572560	10	55	theme	CNFs	1582:1585	arg1	esterification					1564:1577	the esterification	1560:1577	the esterification of CNFs in an aqueous medium	1560:1606	Therefore, the esterification of CNFs in an aqueous medium may provide an environmentally benign way of modifying the surface chemistry of CNFs to improve the barrier properties of CNF films and PLA/CNF composites.
34572560	10	56	theme	composites	1752:1761	arg1	properties					1716:1725	the barrier properties	1704:1725	the barrier properties of CNF films and PLA/CNF composites	1704:1761	Therefore, the esterification of CNFs in an aqueous medium may provide an environmentally benign way of modifying the surface chemistry of CNFs to improve the barrier properties of CNF films and PLA/CNF composites.
34572560	6	57	with	Modification	957:968	arg1	LA					982:983	LA	982:983	LA	982:983	Modification of CNF with LA improved the tensile modulus of the produced films but the tensile strength and elongation decreased.
34572560	7	58	theme	water	1140:1144	arg1	absorption					1146:1155	lower water absorption	1134:1155	lower water absorption	1134:1155	Additionally, films made from modified CNF had lower water absorption, as well as water vapor and oxygen permeability, relative to their counterparts with unmodified CNFs.
34572560	4	59	theme	acid-grafted	660:671	arg1	films					677:681	lactic acid-grafted CNF films	653:681	lactic acid-grafted CNF films	653:681	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	0	60	theme	Composites	162:171	arg1	Properties					78:87	the Properties	74:87	the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites	74:171	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	9	61	theme	acid-grafted	1438:1449	arg1	CNF					1451:1453	lactic acid-grafted CNF	1431:1453	lactic acid-grafted CNF	1431:1453	However, the addition of lactic acid-grafted CNF to PLA improved the water vapor permeability relative to composites containing ungrafted CNF.
34572560	5	62	theme	modified	830:837	arg1	CNF					839:841	the modified CNF	826:841	the modified CNF	826:841	FTIR spectra of the modified CNF revealed the presence of carbonyl peaks at 1720 cm-1, suggesting that the esterification reaction was successful.
34572560	4	63	theme	ungrafted	638:646	arg1	CNF					648:650	ungrafted CNF	638:650	ungrafted CNF	638:650	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	0	64	theme	Cellulose	92:100	arg1	Films					113:117	Cellulose Nanofibril Films	92:117	Cellulose Nanofibril Films	92:117	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	4	65	from	effect	724:729	arg1	nanocomposites					794:807	nanocomposites	794:807	nanocomposites	794:807	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	4	65	from	effect	724:729	arg1	properties					766:775	the properties	762:775	the properties of the films	762:788	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	4	65	from	effect	724:729	arg1	films					784:788	the films	780:788	the films	780:788	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	9	66	theme	water	1475:1479	arg1	permeability					1487:1498	the water vapor permeability	1471:1498	the water vapor permeability relative to composites containing ungrafted CNF	1471:1546	However, the addition of lactic acid-grafted CNF to PLA improved the water vapor permeability relative to composites containing ungrafted CNF.
34572560	0	67	theme	Films	113:117	arg1	Properties					78:87	the Properties	74:87	the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites	74:171	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	6	68	theme	produced	1021:1028	arg1	films					1030:1034	the produced films	1017:1034	the produced films	1017:1034	Modification of CNF with LA improved the tensile modulus of the produced films but the tensile strength and elongation decreased.
34572560	8	69	theme	PLA/CNF	1288:1294	arg1	composites					1296:1305	PLA/CNF composites	1288:1305	PLA/CNF composites made from lactic acid-grafted CNFs	1288:1340	The mechanical properties of PLA/CNF composites made from lactic acid-grafted CNFs did not significantly change with respect to the ungrafted CNF.
34572560	2	70	theme	acid-modified	362:374	arg1	CNF					376:378	unmodified and lactic acid-modified CNF	340:378	unmodified and lactic acid-modified CNF without a polymer matrix	340:403	Films were made from unmodified and lactic acid-modified CNF without a polymer matrix to evaluate the effectiveness of the modification.
34572560	7	71	theme	modified	1117:1124	arg1	CNF					1126:1128	modified CNF	1117:1128	modified CNF	1117:1128	Additionally, films made from modified CNF had lower water absorption, as well as water vapor and oxygen permeability, relative to their counterparts with unmodified CNFs.
34572560	0	72	theme	Acid	20:23	arg1	Modification					33:44	Lactic Acid Surface Modification	13:44	Lactic Acid Surface Modification of Cellulose Nanofibrils	13:69	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	6	73	theme	tensile	998:1004	arg1	modulus					1006:1012	the tensile modulus	994:1012	the tensile modulus of the produced films	994:1034	Modification of CNF with LA improved the tensile modulus of the produced films but the tensile strength and elongation decreased.
34572560	8	74	theme	lactic	1317:1322	arg1	CNFs					1337:1340	lactic acid-grafted CNFs	1317:1340	lactic acid-grafted CNFs	1317:1340	The mechanical properties of PLA/CNF composites made from lactic acid-grafted CNFs did not significantly change with respect to the ungrafted CNF.
34572560	2	75	theme	polymer	390:396	arg1	matrix					398:403	a polymer matrix	388:403	a polymer matrix	388:403	Films were made from unmodified and lactic acid-modified CNF without a polymer matrix to evaluate the effectiveness of the modification.
34572560	0	76	theme	Modification	33:44	arg1	Influence					0:8	Influence	0:8	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.	0:172	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	1	77	theme	aqueous	278:284	arg1	medium					286:291	an aqueous medium	275:291	an aqueous medium with SnCl2 as a catalyst	275:316	In this study, cellulose nanofibrils (CNFs) were modified by catalyzed lactic acid esterification in an aqueous medium with SnCl2 as a catalyst.
34572560	2	78	theme	modification	442:453	arg1	effectiveness					421:433	the effectiveness	417:433	the effectiveness of the modification	417:453	Films were made from unmodified and lactic acid-modified CNF without a polymer matrix to evaluate the effectiveness of the modification.
34572560	7	79	theme	lower	1134:1138	arg1	absorption					1146:1155	lower water absorption	1134:1155	lower water absorption	1134:1155	Additionally, films made from modified CNF had lower water absorption, as well as water vapor and oxygen permeability, relative to their counterparts with unmodified CNFs.
34572560	0	80	theme	Cellulose	49:57	arg1	Nanofibrils					59:69	Cellulose Nanofibrils	49:69	Cellulose Nanofibrils	49:69	Influence of Lactic Acid Surface Modification of Cellulose Nanofibrils on the Properties of Cellulose Nanofibril Films and Cellulose Nanofibril-Poly(lactic acid) Composites.
34572560	3	81	theme	acid-grafted	477:488	arg1	CNF					490:492	lactic acid-grafted CNF	470:492	lactic acid-grafted CNF	470:492	Ungrafted and lactic acid-grafted CNF was also compounded with poly(lactic acid) (PLA) to produce composites.
34572560	5	82	from	cm-1	891:894	arg1	presence					856:863	the presence	852:863	the presence of carbonyl peaks at 1720 cm-1	852:894	FTIR spectra of the modified CNF revealed the presence of carbonyl peaks at 1720 cm-1, suggesting that the esterification reaction was successful.
34572560	9	83	theme	relative	1500:1507	arg1	permeability					1487:1498	the water vapor permeability	1471:1498	the water vapor permeability relative to composites containing ungrafted CNF	1471:1546	However, the addition of lactic acid-grafted CNF to PLA improved the water vapor permeability relative to composites containing ungrafted CNF.
34572560	4	84	theme	lactic	734:739	arg1	modification					746:757	lactic acid modification	734:757	lactic acid modification	734:757	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	10	85	theme	benign	1639:1644	arg1	way					1646:1648	an environmentally benign way	1620:1648	an environmentally benign way of modifying the surface chemistry of CNFs to improve the barrier properties of CNF films and PLA/CNF composites	1620:1761	Therefore, the esterification of CNFs in an aqueous medium may provide an environmentally benign way of modifying the surface chemistry of CNFs to improve the barrier properties of CNF films and PLA/CNF composites.
34572560	6	86	theme	tensile	1044:1050	arg1	strength					1052:1059	the tensile strength	1040:1059	the tensile strength	1040:1059	Modification of CNF with LA improved the tensile modulus of the produced films but the tensile strength and elongation decreased.
34572560	10	87	theme	aqueous	1593:1599	arg1	medium					1601:1606	an aqueous medium	1590:1606	an aqueous medium	1590:1606	Therefore, the esterification of CNFs in an aqueous medium may provide an environmentally benign way of modifying the surface chemistry of CNFs to improve the barrier properties of CNF films and PLA/CNF composites.
34572560	4	88	theme	water	578:582	arg1	absorption					584:593	water absorption	578:593	water absorption	578:593	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34572560	4	89	theme	modification	746:757	arg1	effect					724:729	the effect	720:729	the effect of lactic acid modification on the properties of the films and nanocomposites	720:807	Mechanical, water absorption, and barrier properties were evaluated for ungrafted CNF, lactic acid-grafted CNF films, and PLA/CNF composites to ascertain the effect of lactic acid modification on the properties of the films and nanocomposites.
34129712	6	0	theme	pectin	869:874	arg1	different					910:918	different	910:918	different	910:918	Results showed that the flocculation performance of pectin arising from different fruits was different, which was associated with the various preparation processes.
34129712	6	0	theme	pectin	869:874	arg1	performance					854:864	the flocculation performance	837:864	the flocculation performance of pectin arising from different fruits	837:904	Results showed that the flocculation performance of pectin arising from different fruits was different, which was associated with the various preparation processes.
34129712	13	1	theme	influencing	1680:1690	arg1	factors					1692:1698	different influencing factors	1670:1698	different influencing factors	1670:1698	Response surface method to study the interaction of different influencing factors.
34129712	9	2	theme	amidated	1271:1278	arg1	pectin					1280:1285	The optimized amidated pectin	1257:1285	The optimized amidated pectin	1257:1285	The optimized amidated pectin was obtained by the amidation experiment, the turbidity reduction in wastewater was 99.63%.
34129712	9	3	from	reduction	1343:1351	arg1	wastewater					1356:1365	wastewater	1356:1365	wastewater	1356:1365	The optimized amidated pectin was obtained by the amidation experiment, the turbidity reduction in wastewater was 99.63%.
34129712	4	4	theme	pectin	552:557	arg1	values					542:547	The DE/DA values	532:547	The DE/DA values of pectin	532:557	The DE/DA values of pectin were obtained through FTIR, elemental analyses, H-NMR, and titration measurements.
34129712	5	5	theme	NTU	727:729	arg1	removal					716:722	the removal	712:722	the removal of NTU (Nephelometric Turbidity Unit)	712:760	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	5	5	theme	NTU	727:729	arg1	index					778:782	the index	774:782	the index of the flocculation performance	774:814	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	13	6	theme	factors	1692:1698	arg1	interaction					1655:1665	the interaction	1651:1665	the interaction of different influencing factors	1651:1698	Response surface method to study the interaction of different influencing factors.
34129712	14	7	theme	synthetic	1720:1728	arg1	flocculants					1730:1740	synthetic flocculants	1720:1740	synthetic flocculants	1720:1740	Pectin may replace synthetic flocculants in water treatment.
34129712	5	8	theme	jar	697:699	arg1	tests					701:705	the coagulation jar tests	681:705	the coagulation jar tests	681:705	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	0	9	from	Study	0:4	arg1	factors					25:31	the influencing factors	9:31	the influencing factors of natural pectin's flocculation: Their sources, modification, and optimization	9:111	Study on the influencing factors of natural pectin's flocculation: Their sources, modification, and optimization.
34129712	10	10	theme	PRACTITIONER	1379:1390	arg1	POINTS					1392:1397	PRACTITIONER POINTS	1379:1397	PRACTITIONER POINTS: The internal influencing factors of pectin as a flocculant were investigated.	1379:1476	PRACTITIONER POINTS: The internal influencing factors of pectin as a flocculant were investigated.
34129712	11	11	theme	pectin	1499:1504	arg1	sources					1488:1494	Different sources	1478:1494	Different sources of pectin	1478:1504	Different sources of pectin show different flocculation ability.
34129712	3	12	theme	flocculation	506:517	arg1	performance					519:529	flocculation performance	506:529	flocculation performance	506:529	In this study, degree of esterification (DE), degree of amidation (DA) were used as the internal factors affecting flocculation performance.
34129712	6	13	theme	flocculation	841:852	arg1	different					910:918	different	910:918	different	910:918	Results showed that the flocculation performance of pectin arising from different fruits was different, which was associated with the various preparation processes.
34129712	6	13	theme	flocculation	841:852	arg1	performance					854:864	the flocculation performance	837:864	the flocculation performance of pectin arising from different fruits	837:904	Results showed that the flocculation performance of pectin arising from different fruits was different, which was associated with the various preparation processes.
34129712	11	14	theme	Different	1478:1486	arg1	sources					1488:1494	Different sources	1478:1494	Different sources of pectin	1478:1504	Different sources of pectin show different flocculation ability.
34129712	14	15	theme	water	1745:1749	arg1	treatment					1751:1759	water treatment	1745:1759	water treatment	1745:1759	Pectin may replace synthetic flocculants in water treatment.
34129712	5	16	theme	flocculation	791:802	arg1	performance					804:814	the flocculation performance	787:814	the flocculation performance	787:814	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	13	17	theme	surface	1627:1633	arg1	method					1635:1640	Response surface method	1618:1640	Response surface method	1618:1640	Response surface method to study the interaction of different influencing factors.
34129712	3	18	theme	amidation	447:455	arg1	degree					437:442	degree	437:442	degree of amidation (DA)	437:460	In this study, degree of esterification (DE), degree of amidation (DA) were used as the internal factors affecting flocculation performance.
34129712	3	18	theme	amidation	447:455	arg1	esterification					416:429	esterification	416:429	esterification (DE)	416:434	In this study, degree of esterification (DE), degree of amidation (DA) were used as the internal factors affecting flocculation performance.
34129712	3	18	theme	amidation	447:455	arg1	DA					458:459	DA	458:459	DA	458:459	In this study, degree of esterification (DE), degree of amidation (DA) were used as the internal factors affecting flocculation performance.
34129712	2	19	theme	extraction	248:257	arg1	process					237:243	the process	233:243	the process of extraction and treatment	233:271	However, the process of extraction and treatment affected the flocculation performance considering the uncontrollable chemical composition and the molecule structure.
34129712	1	20	theme	fruit	143:147	arg1	residue					149:155	fruit residue	143:155	fruit residue	143:155	Natural pectin, derived from fruit residue, presented a certain flocculation performance in previous studies.
34129712	10	21	dep	POINTS	1392:1397	arg1	investigated					1464:1475	investigated	1464:1475	were investigated	1459:1475	PRACTITIONER POINTS: The internal influencing factors of pectin as a flocculant were investigated.
34129712	9	22	theme	optimized	1261:1269	arg1	pectin					1280:1285	The optimized amidated pectin	1257:1285	The optimized amidated pectin	1257:1285	The optimized amidated pectin was obtained by the amidation experiment, the turbidity reduction in wastewater was 99.63%.
34129712	6	23	theme	various	951:957	arg1	processes					971:979	the various preparation processes	947:979	the various preparation processes	947:979	Results showed that the flocculation performance of pectin arising from different fruits was different, which was associated with the various preparation processes.
34129712	11	24	theme	flocculation	1521:1532	arg1	ability					1534:1540	different flocculation ability	1511:1540	different flocculation ability	1511:1540	Different sources of pectin show different flocculation ability.
34129712	9	25	theme	turbidity	1333:1341	arg1	reduction					1343:1351	the turbidity reduction	1329:1351	the turbidity reduction in wastewater	1329:1365	The optimized amidated pectin was obtained by the amidation experiment, the turbidity reduction in wastewater was 99.63%.
34129712	9	25	theme	turbidity	1333:1341	arg1	%					1376:1376	99.63%	1371:1376	99.63%	1371:1376	The optimized amidated pectin was obtained by the amidation experiment, the turbidity reduction in wastewater was 99.63%.
34129712	5	26	theme	performance	804:814	arg1	removal					716:722	the removal	712:722	the removal of NTU (Nephelometric Turbidity Unit)	712:760	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	5	26	theme	performance	804:814	arg1	index					778:782	the index	774:782	the index of the flocculation performance	774:814	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	2	27	theme	treatment	263:271	arg1	process					237:243	the process	233:243	the process of extraction and treatment	233:271	However, the process of extraction and treatment affected the flocculation performance considering the uncontrollable chemical composition and the molecule structure.
34129712	1	28	attach	derived	130:136	arg2	pectin					122:127	Natural pectin	114:127	Natural pectin	114:127	Natural pectin, derived from fruit residue, presented a certain flocculation performance in previous studies.
34129712	1	28	attach	derived	130:136	arg1	residue					149:155	fruit residue	143:155	fruit residue	143:155	Natural pectin, derived from fruit residue, presented a certain flocculation performance in previous studies.
34129712	10	29	theme	internal	1404:1411	arg1	factors					1425:1431	The internal influencing factors	1400:1431	The internal influencing factors of pectin as a flocculant	1400:1457	PRACTITIONER POINTS: The internal influencing factors of pectin as a flocculant were investigated.
34129712	5	30	theme	kaolin	646:651	arg1	suspension					653:662	The kaolin suspension	642:662	The kaolin suspension	642:662	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	3	31	theme	esterification	416:429	arg1	factors					488:494	the internal factors	475:494	the internal factors affecting flocculation performance	475:529	In this study, degree of esterification (DE), degree of amidation (DA) were used as the internal factors affecting flocculation performance.
34129712	3	31	theme	esterification	416:429	arg1	degree					406:411	degree	406:411	degree of esterification (DE), degree of amidation (DA)	406:460	In this study, degree of esterification (DE), degree of amidation (DA) were used as the internal factors affecting flocculation performance.
34129712	7	32	theme	charge	1093:1098	arg1	neutralization					1100:1113	charge neutralization	1093:1113	charge neutralization	1093:1113	By introducing polar groups into pectin, the flocculation was found to be related to bridging, adsorption, and charge neutralization.
34129712	13	33	theme	different	1670:1678	arg1	factors					1692:1698	different influencing factors	1670:1698	different influencing factors	1670:1698	Response surface method to study the interaction of different influencing factors.
34129712	2	34	theme	flocculation	286:297	arg1	performance					299:309	the flocculation performance	282:309	the flocculation performance considering the uncontrollable chemical composition and the molecule structure	282:388	However, the process of extraction and treatment affected the flocculation performance considering the uncontrollable chemical composition and the molecule structure.
34129712	12	35	theme	pectin	1610:1615	arg1	performance					1595:1605	the flocculation performance	1578:1605	the flocculation performance of pectin	1578:1615	Amidation modification can improve the flocculation performance of pectin.
34129712	0	36	theme	influencing	13:23	arg1	factors					25:31	the influencing factors	9:31	the influencing factors of natural pectin's flocculation: Their sources, modification, and optimization	9:111	Study on the influencing factors of natural pectin's flocculation: Their sources, modification, and optimization.
34129712	13	37	theme	Response	1618:1625	arg1	method					1635:1640	Response surface method	1618:1640	Response surface method	1618:1640	Response surface method to study the interaction of different influencing factors.
34129712	8	38	theme	increased	1243:1251	arg1	DA					1253:1254	the increased DA	1239:1254	the increased DA	1239:1254	Based on the trends of three-dimensional response surfaces, the flocculation effect was improved with the decreased DE and the increased DA.
34129712	11	39	theme	different	1511:1519	arg1	ability					1534:1540	different flocculation ability	1511:1540	different flocculation ability	1511:1540	Different sources of pectin show different flocculation ability.
34129712	1	40	theme	certain	170:176	arg1	performance					191:201	a certain flocculation performance	168:201	a certain flocculation performance	168:201	Natural pectin, derived from fruit residue, presented a certain flocculation performance in previous studies.
34129712	8	41	theme	surfaces	1166:1173	arg1	trends					1129:1134	the trends	1125:1134	the trends of three-dimensional response surfaces	1125:1173	Based on the trends of three-dimensional response surfaces, the flocculation effect was improved with the decreased DE and the increased DA.
34129712	4	42	theme	DE/DA	536:540	arg1	values					542:547	The DE/DA values	532:547	The DE/DA values of pectin	532:557	The DE/DA values of pectin were obtained through FTIR, elemental analyses, H-NMR, and titration measurements.
34129712	10	43	theme	pectin	1436:1441	arg1	factors					1425:1431	The internal influencing factors	1400:1431	The internal influencing factors of pectin as a flocculant	1400:1457	PRACTITIONER POINTS: The internal influencing factors of pectin as a flocculant were investigated.
34129712	12	44	theme	flocculation	1582:1593	arg1	performance					1595:1605	the flocculation performance	1578:1605	the flocculation performance of pectin	1578:1615	Amidation modification can improve the flocculation performance of pectin.
34129712	1	45	theme	flocculation	178:189	arg1	performance					191:201	a certain flocculation performance	168:201	a certain flocculation performance	168:201	Natural pectin, derived from fruit residue, presented a certain flocculation performance in previous studies.
34129712	4	46	theme	titration	618:626	arg1	measurements					628:639	titration measurements	618:639	titration measurements	618:639	The DE/DA values of pectin were obtained through FTIR, elemental analyses, H-NMR, and titration measurements.
34129712	12	47	theme	Amidation	1543:1551	arg1	modification					1553:1564	Amidation modification	1543:1564	Amidation modification	1543:1564	Amidation modification can improve the flocculation performance of pectin.
34129712	5	48	theme	coagulation	685:695	arg1	tests					701:705	the coagulation jar tests	681:705	the coagulation jar tests	681:705	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	1	49	attach	presented	158:166	arg1	studies					215:221	previous studies	206:221	previous studies	206:221	Natural pectin, derived from fruit residue, presented a certain flocculation performance in previous studies.
34129712	1	49	attach	presented	158:166	arg2	pectin					122:127	Natural pectin	114:127	Natural pectin	114:127	Natural pectin, derived from fruit residue, presented a certain flocculation performance in previous studies.
34129712	8	50	theme	three-dimensional	1139:1155	arg1	surfaces					1166:1173	three-dimensional response surfaces	1139:1173	three-dimensional response surfaces	1139:1173	Based on the trends of three-dimensional response surfaces, the flocculation effect was improved with the decreased DE and the increased DA.
34129712	8	51	theme	decreased	1222:1230	arg1	DE					1232:1233	the decreased DE	1218:1233	the decreased DE	1218:1233	Based on the trends of three-dimensional response surfaces, the flocculation effect was improved with the decreased DE and the increased DA.
34129712	5	52	theme	Turbidity	746:754	arg1	Unit					756:759	Nephelometric Turbidity Unit	732:759	Nephelometric Turbidity Unit	732:759	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	5	52	theme	Turbidity	746:754	arg1	NTU					727:729	NTU	727:729	NTU (Nephelometric Turbidity Unit)	727:760	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	9	53	theme	amidation	1307:1315	arg1	experiment					1317:1326	the amidation experiment	1303:1326	the amidation experiment	1303:1326	The optimized amidated pectin was obtained by the amidation experiment, the turbidity reduction in wastewater was 99.63%.
34129712	8	54	theme	response	1157:1164	arg1	surfaces					1166:1173	three-dimensional response surfaces	1139:1173	three-dimensional response surfaces	1139:1173	Based on the trends of three-dimensional response surfaces, the flocculation effect was improved with the decreased DE and the increased DA.
34129712	2	55	theme	chemical	342:349	arg1	composition					351:361	the uncontrollable chemical composition	323:361	the uncontrollable chemical composition	323:361	However, the process of extraction and treatment affected the flocculation performance considering the uncontrollable chemical composition and the molecule structure.
34129712	0	56	theme	natural	36:42	arg1	flocculation					53:64	natural pectin's flocculation	36:64	natural pectin's flocculation	36:64	Study on the influencing factors of natural pectin's flocculation: Their sources, modification, and optimization.
34129712	6	57	theme	different	889:897	arg1	fruits					899:904	different fruits	889:904	different fruits	889:904	Results showed that the flocculation performance of pectin arising from different fruits was different, which was associated with the various preparation processes.
34129712	5	58	used	used	766:769	arg2	removal					716:722	the removal	712:722	the removal of NTU (Nephelometric Turbidity Unit)	712:760	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	5	58	used	used	766:769	arg2	index					778:782	the index	774:782	the index of the flocculation performance	774:814	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	10	59	theme	influencing	1413:1423	arg1	factors					1425:1431	The internal influencing factors	1400:1431	The internal influencing factors of pectin as a flocculant	1400:1457	PRACTITIONER POINTS: The internal influencing factors of pectin as a flocculant were investigated.
34129712	2	60	theme	uncontrollable	327:340	arg1	composition					351:361	the uncontrollable chemical composition	323:361	the uncontrollable chemical composition	323:361	However, the process of extraction and treatment affected the flocculation performance considering the uncontrollable chemical composition and the molecule structure.
34129712	7	61	theme	polar	997:1001	arg1	groups					1003:1008	polar groups	997:1008	polar groups	997:1008	By introducing polar groups into pectin, the flocculation was found to be related to bridging, adsorption, and charge neutralization.
34129712	3	62	used	used	467:470	arg2	factors					488:494	the internal factors	475:494	the internal factors affecting flocculation performance	475:529	In this study, degree of esterification (DE), degree of amidation (DA) were used as the internal factors affecting flocculation performance.
34129712	3	62	used	used	467:470	arg2	degree					406:411	degree	406:411	degree of esterification (DE), degree of amidation (DA)	406:460	In this study, degree of esterification (DE), degree of amidation (DA) were used as the internal factors affecting flocculation performance.
34129712	1	63	theme	Natural	114:120	arg1	pectin					122:127	Natural pectin	114:127	Natural pectin	114:127	Natural pectin, derived from fruit residue, presented a certain flocculation performance in previous studies.
34129712	1	64	theme	previous	206:213	arg1	studies					215:221	previous studies	206:221	previous studies	206:221	Natural pectin, derived from fruit residue, presented a certain flocculation performance in previous studies.
34129712	2	65	theme	molecule	371:378	arg1	structure					380:388	the molecule structure	367:388	the molecule structure	367:388	However, the process of extraction and treatment affected the flocculation performance considering the uncontrollable chemical composition and the molecule structure.
34129712	8	66	theme	flocculation	1180:1191	arg1	effect					1193:1198	the flocculation effect	1176:1198	the flocculation effect	1176:1198	Based on the trends of three-dimensional response surfaces, the flocculation effect was improved with the decreased DE and the increased DA.
34129712	4	67	theme	elemental	587:595	arg1	analyses					597:604	elemental analyses	587:604	elemental analyses	587:604	The DE/DA values of pectin were obtained through FTIR, elemental analyses, H-NMR, and titration measurements.
34129712	5	68	theme	Nephelometric	732:744	arg1	Unit					756:759	Nephelometric Turbidity Unit	732:759	Nephelometric Turbidity Unit	732:759	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	5	68	theme	Nephelometric	732:744	arg1	NTU					727:729	NTU	727:729	NTU (Nephelometric Turbidity Unit)	727:760	The kaolin suspension was employed for the coagulation jar tests, and the removal of NTU (Nephelometric Turbidity Unit) was used as the index of the flocculation performance.
34129712	3	69	theme	internal	479:486	arg1	factors					488:494	the internal factors	475:494	the internal factors affecting flocculation performance	475:529	In this study, degree of esterification (DE), degree of amidation (DA) were used as the internal factors affecting flocculation performance.
34129712	3	69	theme	internal	479:486	arg1	degree					406:411	degree	406:411	degree of esterification (DE), degree of amidation (DA)	406:460	In this study, degree of esterification (DE), degree of amidation (DA) were used as the internal factors affecting flocculation performance.
34129712	6	70	theme	preparation	959:969	arg1	processes					971:979	the various preparation processes	947:979	the various preparation processes	947:979	Results showed that the flocculation performance of pectin arising from different fruits was different, which was associated with the various preparation processes.
34284052	0	0	theme	cellulose	66:74	arg1	nanocrystals					76:87	acetylated cellulose nanocrystals	55:87	acetylated cellulose nanocrystals	55:87	Poly(lactic acid)-based composite film reinforced with acetylated cellulose nanocrystals and ZnO nanoparticles for active food packaging.
34284052	0	1	theme	acetylated	55:64	arg1	nanocrystals					76:87	acetylated cellulose nanocrystals	55:87	acetylated cellulose nanocrystals	55:87	Poly(lactic acid)-based composite film reinforced with acetylated cellulose nanocrystals and ZnO nanoparticles for active food packaging.
34284052	8	2	theme	resulting	1119:1127	arg1	film					1160:1163	the resulting PLA/ACNC/ZnO ternary composite film	1115:1163	the resulting PLA/ACNC/ZnO ternary composite film	1115:1163	Overall, the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film highlighted the potential application as a promising option for active food packaging materials.
34284052	1	3	theme	lactic	143:148	arg1	Poly					138:141	Poly	138:141	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%)	138:247	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	1	3	theme	lactic	143:148	arg1	acid					150:153	lactic acid	143:153	lactic acid	143:153	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	8	4	theme	active	1229:1234	arg1	materials					1251:1259	active food packaging materials	1229:1259	active food packaging materials	1229:1259	Overall, the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film highlighted the potential application as a promising option for active food packaging materials.
34284052	4	5	theme	homogenous	677:686	arg1	film					688:691	homogenous film	677:691	homogenous film	677:691	SEM images showed that ACNC and ZnO were evenly distributed in the PLA matrix to form homogenous film when the content of ZnO was ≤5 wt%.
34284052	3	6	theme	optical	465:471	arg1	morphologies					451:462	The morphologies	447:462	The morphologies	447:462	The morphologies, optical, mechanical, barrier, thermal and antibacterial properties of PLA/ACNC/ZnO ternary composite films were investigated.
34284052	6	7	theme	antibacterial	892:904	arg1	activity					906:913	excellent antibacterial activity	882:913	excellent antibacterial activity against E. coli and S. aureus	882:943	This ternary composite also exhibited excellent antibacterial activity against E. coli and S. aureus.
34284052	2	8	theme	PLA	435:437	arg1	matrix					439:444	the PLA matrix	431:444	the PLA matrix	431:444	The surface acetylation of cellulose nanocrystals improved its dispersion in the PLA matrix.
34284052	8	9	theme	promising	1208:1216	arg1	option					1218:1223	a promising option	1206:1223	a promising option for active food packaging materials	1206:1259	Overall, the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film highlighted the potential application as a promising option for active food packaging materials.
34284052	8	9	theme	promising	1208:1216	arg1	application					1191:1201	the potential application	1177:1201	the potential application	1177:1201	Overall, the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film highlighted the potential application as a promising option for active food packaging materials.
34284052	5	10	theme	PLA/ACNC/ZnO	733:744	arg1	films					756:760	The PLA/ACNC/ZnO composite films	729:760	The PLA/ACNC/ZnO composite films	729:760	The PLA/ACNC/ZnO composite films showed improved UV blocking, mechanical strength, oxygen and water vapor barrier.
34284052	4	11	theme	SEM	591:593	arg1	images					595:600	SEM images	591:600	SEM images	591:600	SEM images showed that ACNC and ZnO were evenly distributed in the PLA matrix to form homogenous film when the content of ZnO was ≤5 wt%.
34284052	0	12	theme	ZnO	93:95	arg1	nanoparticles					97:109	ZnO nanoparticles	93:109	ZnO nanoparticles	93:109	Poly(lactic acid)-based composite film reinforced with acetylated cellulose nanocrystals and ZnO nanoparticles for active food packaging.
34284052	2	13	theme	nanocrystals	391:402	arg1	acetylation					366:376	The surface acetylation	354:376	The surface acetylation of cellulose nanocrystals	354:402	The surface acetylation of cellulose nanocrystals improved its dispersion in the PLA matrix.
34284052	5	14	theme	improved	769:776	arg1	blocking					781:788	improved UV blocking	769:788	improved UV blocking	769:788	The PLA/ACNC/ZnO composite films showed improved UV blocking, mechanical strength, oxygen and water vapor barrier.
34284052	2	15	theme	surface	358:364	arg1	acetylation					366:376	The surface acetylation	354:376	The surface acetylation of cellulose nanocrystals	354:402	The surface acetylation of cellulose nanocrystals improved its dispersion in the PLA matrix.
34284052	7	16	theme	composite	994:1002	arg1	film					1004:1007	PLA/ACNC/ZnO composite film	981:1007	PLA/ACNC/ZnO composite film to food simulants	981:1025	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants were below the specific migration limit (5 mg/kg).
34284052	4	17	theme	PLA	658:660	arg1	matrix					662:667	the PLA matrix	654:667	the PLA matrix	654:667	SEM images showed that ACNC and ZnO were evenly distributed in the PLA matrix to form homogenous film when the content of ZnO was ≤5 wt%.
34284052	5	18	theme	UV	778:779	arg1	blocking					781:788	improved UV blocking	769:788	improved UV blocking	769:788	The PLA/ACNC/ZnO composite films showed improved UV blocking, mechanical strength, oxygen and water vapor barrier.
34284052	6	19	theme	excellent	882:890	arg1	activity					906:913	excellent antibacterial activity	882:913	excellent antibacterial activity against E. coli and S. aureus	882:943	This ternary composite also exhibited excellent antibacterial activity against E. coli and S. aureus.
34284052	8	20	theme	composite	1150:1158	arg1	film					1160:1163	the resulting PLA/ACNC/ZnO ternary composite film	1115:1163	the resulting PLA/ACNC/ZnO ternary composite film	1115:1163	Overall, the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film highlighted the potential application as a promising option for active food packaging materials.
34284052	0	21	theme	composite	24:32	arg1	film					34:37	Poly(lactic acid)-based composite film	0:37	Poly(lactic acid)-based composite film	0:37	Poly(lactic acid)-based composite film reinforced with acetylated cellulose nanocrystals and ZnO nanoparticles for active food packaging.
34284052	8	22	theme	film	1160:1163	arg1	properties					1101:1110	the desirable properties	1087:1110	the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film	1087:1163	Overall, the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film highlighted the potential application as a promising option for active food packaging materials.
34284052	5	23	theme	composite	746:754	arg1	films					756:760	The PLA/ACNC/ZnO composite films	729:760	The PLA/ACNC/ZnO composite films	729:760	The PLA/ACNC/ZnO composite films showed improved UV blocking, mechanical strength, oxygen and water vapor barrier.
34284052	1	24	theme	1 wt	242:245	arg1	%					246:246	1 wt%	242:246	1 wt%	242:246	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	1	24	theme	1 wt	242:245	arg1	Poly					138:141	Poly	138:141	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%)	138:247	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	0	25	theme	active	115:120	arg1	packaging					127:135	active food packaging	115:135	active food packaging	115:135	Poly(lactic acid)-based composite film reinforced with acetylated cellulose nanocrystals and ZnO nanoparticles for active food packaging.
34284052	8	26	theme	packaging	1241:1249	arg1	materials					1251:1259	active food packaging materials	1229:1259	active food packaging materials	1229:1259	Overall, the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film highlighted the potential application as a promising option for active food packaging materials.
34284052	8	27	theme	potential	1181:1189	arg1	option					1218:1223	a promising option	1206:1223	a promising option for active food packaging materials	1206:1259	Overall, the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film highlighted the potential application as a promising option for active food packaging materials.
34284052	8	27	theme	potential	1181:1189	arg1	application					1191:1201	the potential application	1177:1201	the potential application	1177:1201	Overall, the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film highlighted the potential application as a promising option for active food packaging materials.
34284052	0	28	theme	lactic	5:10	arg1	acid					12:15	lactic acid	5:15	lactic acid	5:15	Poly(lactic acid)-based composite film reinforced with acetylated cellulose nanocrystals and ZnO nanoparticles for active food packaging.
34284052	7	29	theme	PLA/ACNC/ZnO	981:992	arg1	film					1004:1007	PLA/ACNC/ZnO composite film	981:1007	PLA/ACNC/ZnO composite film to food simulants	981:1025	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants were below the specific migration limit (5 mg/kg).
34284052	1	30	dep	Poly	138:141	arg1	films					178:182	-based composite films	161:182	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%)	138:247	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	1	31	theme	-based	161:166	arg1	films					178:182	-based composite films	161:182	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%)	138:247	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	0	32	theme	-based	17:22	arg1	film					34:37	Poly(lactic acid)-based composite film	0:37	Poly(lactic acid)-based composite film	0:37	Poly(lactic acid)-based composite film reinforced with acetylated cellulose nanocrystals and ZnO nanoparticles for active food packaging.
34284052	1	33	theme	7 wt	305:308	arg1	%					309:309	1, 3, 5 and 7 wt%	293:309	1, 3, 5 and 7 wt%	293:309	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	1	33	theme	7 wt	305:308	arg1	content					284:290	different content	274:290	different content (1, 3, 5 and 7 wt%)	274:310	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	8	34	theme	food	1236:1239	arg1	materials					1251:1259	active food packaging materials	1229:1259	active food packaging materials	1229:1259	Overall, the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film highlighted the potential application as a promising option for active food packaging materials.
34284052	1	35	theme	composite	168:176	arg1	films					178:182	-based composite films	161:182	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%)	138:247	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	2	36	theme	cellulose	381:389	arg1	nanocrystals					391:402	cellulose nanocrystals	381:402	cellulose nanocrystals	381:402	The surface acetylation of cellulose nanocrystals improved its dispersion in the PLA matrix.
34284052	6	37	theme	ternary	849:855	arg1	composite					857:865	This ternary composite	844:865	This ternary composite	844:865	This ternary composite also exhibited excellent antibacterial activity against E. coli and S. aureus.
34284052	0	38	theme	food	122:125	arg1	packaging					127:135	active food packaging	115:135	active food packaging	115:135	Poly(lactic acid)-based composite film reinforced with acetylated cellulose nanocrystals and ZnO nanoparticles for active food packaging.
34284052	3	39	theme	composite	556:564	arg1	films					566:570	PLA/ACNC/ZnO ternary composite films	535:570	PLA/ACNC/ZnO ternary composite films	535:570	The morphologies, optical, mechanical, barrier, thermal and antibacterial properties of PLA/ACNC/ZnO ternary composite films were investigated.
34284052	3	40	theme	antibacterial	507:519	arg1	properties					521:530	antibacterial properties	507:530	antibacterial properties of PLA/ACNC/ZnO ternary composite films	507:570	The morphologies, optical, mechanical, barrier, thermal and antibacterial properties of PLA/ACNC/ZnO ternary composite films were investigated.
34284052	7	41	theme	specific	1042:1049	arg1	limit					1061:1065	the specific migration limit	1038:1065	the specific migration limit (5 mg/kg)	1038:1075	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants were below the specific migration limit (5 mg/kg).
34284052	7	41	theme	specific	1042:1049	arg1	5 mg/kg					1068:1074	5 mg/kg	1068:1074	5 mg/kg	1068:1074	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants were below the specific migration limit (5 mg/kg).
34284052	1	42	theme	ZnO	253:255	arg1	nanoparticles					257:269	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles	138:269	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%)	138:310	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	7	43	theme	migration	950:958	arg1	Zn2+					971:974	Zn2+	971:974	Zn2+	971:974	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants were below the specific migration limit (5 mg/kg).
34284052	7	43	theme	migration	950:958	arg1	amounts					960:966	The migration amounts	946:966	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants	946:1025	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants were below the specific migration limit (5 mg/kg).
34284052	2	44	from	dispersion	417:426	arg1	matrix					439:444	the PLA matrix	431:444	the PLA matrix	431:444	The surface acetylation of cellulose nanocrystals improved its dispersion in the PLA matrix.
34284052	0	45	dep	-based	17:22	arg1	acid					12:15	lactic acid	5:15	lactic acid	5:15	Poly(lactic acid)-based composite film reinforced with acetylated cellulose nanocrystals and ZnO nanoparticles for active food packaging.
34284052	7	46	theme	Zn2+	971:974	arg1	Zn2+					971:974	Zn2+	971:974	Zn2+	971:974	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants were below the specific migration limit (5 mg/kg).
34284052	7	46	theme	Zn2+	971:974	arg1	amounts					960:966	The migration amounts	946:966	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants	946:1025	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants were below the specific migration limit (5 mg/kg).
34284052	1	47	from	content	284:290	arg1	nanoparticles					257:269	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles	138:269	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%)	138:310	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	3	48	theme	films	566:570	arg1	morphologies					451:462	The morphologies	447:462	The morphologies	447:462	The morphologies, optical, mechanical, barrier, thermal and antibacterial properties of PLA/ACNC/ZnO ternary composite films were investigated.
34284052	3	48	theme	films	566:570	arg1	properties					521:530	antibacterial properties	507:530	antibacterial properties of PLA/ACNC/ZnO ternary composite films	507:570	The morphologies, optical, mechanical, barrier, thermal and antibacterial properties of PLA/ACNC/ZnO ternary composite films were investigated.
34284052	7	49	theme	food	1012:1015	arg1	simulants					1017:1025	food simulants	1012:1025	food simulants	1012:1025	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants were below the specific migration limit (5 mg/kg).
34284052	7	50	theme	migration	1051:1059	arg1	limit					1061:1065	the specific migration limit	1038:1065	the specific migration limit (5 mg/kg)	1038:1075	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants were below the specific migration limit (5 mg/kg).
34284052	7	50	theme	migration	1051:1059	arg1	5 mg/kg					1068:1074	5 mg/kg	1068:1074	5 mg/kg	1068:1074	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants were below the specific migration limit (5 mg/kg).
34284052	3	51	theme	PLA/ACNC/ZnO	535:546	arg1	films					566:570	PLA/ACNC/ZnO ternary composite films	535:570	PLA/ACNC/ZnO ternary composite films	535:570	The morphologies, optical, mechanical, barrier, thermal and antibacterial properties of PLA/ACNC/ZnO ternary composite films were investigated.
34284052	5	52	dep	blocking	781:788	arg1	barrier					835:841	barrier	835:841	barrier	835:841	The PLA/ACNC/ZnO composite films showed improved UV blocking, mechanical strength, oxygen and water vapor barrier.
34284052	5	53	theme	water	823:827	arg1	vapor					829:833	water vapor	823:833	water vapor	823:833	The PLA/ACNC/ZnO composite films showed improved UV blocking, mechanical strength, oxygen and water vapor barrier.
34284052	3	54	theme	ternary	548:554	arg1	films					566:570	PLA/ACNC/ZnO ternary composite films	535:570	PLA/ACNC/ZnO ternary composite films	535:570	The morphologies, optical, mechanical, barrier, thermal and antibacterial properties of PLA/ACNC/ZnO ternary composite films were investigated.
34284052	7	55	from	film	1004:1007	arg1	Zn2+					971:974	Zn2+	971:974	Zn2+	971:974	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants were below the specific migration limit (5 mg/kg).
34284052	7	55	from	film	1004:1007	arg1	amounts					960:966	The migration amounts	946:966	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants	946:1025	The migration amounts of Zn2+ from PLA/ACNC/ZnO composite film to food simulants were below the specific migration limit (5 mg/kg).
34284052	3	56	dep	optical	465:471	arg1	mechanical					474:483	mechanical	474:483	mechanical	474:483	The morphologies, optical, mechanical, barrier, thermal and antibacterial properties of PLA/ACNC/ZnO ternary composite films were investigated.
34284052	3	56	dep	optical	465:471	arg1	thermal					495:501	thermal	495:501	thermal	495:501	The morphologies, optical, mechanical, barrier, thermal and antibacterial properties of PLA/ACNC/ZnO ternary composite films were investigated.
34284052	3	56	dep	optical	465:471	arg1	barrier					486:492	barrier	486:492	barrier	486:492	The morphologies, optical, mechanical, barrier, thermal and antibacterial properties of PLA/ACNC/ZnO ternary composite films were investigated.
34284052	1	57	theme	solution-casting	329:344	arg1	method					346:351	solution-casting method	329:351	solution-casting method	329:351	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	4	58	theme	ZnO	713:715	arg1	%					726:726	≤5 wt%	721:726	≤5 wt%	721:726	SEM images showed that ACNC and ZnO were evenly distributed in the PLA matrix to form homogenous film when the content of ZnO was ≤5 wt%.
34284052	4	58	theme	ZnO	713:715	arg1	content					702:708	the content	698:708	the content of ZnO	698:715	SEM images showed that ACNC and ZnO were evenly distributed in the PLA matrix to form homogenous film when the content of ZnO was ≤5 wt%.
34284052	5	59	theme	mechanical	791:800	arg1	strength					802:809	mechanical strength	791:809	mechanical strength	791:809	The PLA/ACNC/ZnO composite films showed improved UV blocking, mechanical strength, oxygen and water vapor barrier.
34284052	8	60	theme	ternary	1142:1148	arg1	film					1160:1163	the resulting PLA/ACNC/ZnO ternary composite film	1115:1163	the resulting PLA/ACNC/ZnO ternary composite film	1115:1163	Overall, the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film highlighted the potential application as a promising option for active food packaging materials.
34284052	1	61	theme	acetylated	200:209	arg1	nanocrystals					221:232	acetylated cellulose nanocrystals	200:232	acetylated cellulose nanocrystals	200:232	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	8	62	theme	PLA/ACNC/ZnO	1129:1140	arg1	film					1160:1163	the resulting PLA/ACNC/ZnO ternary composite film	1115:1163	the resulting PLA/ACNC/ZnO ternary composite film	1115:1163	Overall, the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film highlighted the potential application as a promising option for active food packaging materials.
34284052	1	63	theme	different	274:282	arg1	%					309:309	1, 3, 5 and 7 wt%	293:309	1, 3, 5 and 7 wt%	293:309	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	1	63	theme	different	274:282	arg1	content					284:290	different content	274:290	different content (1, 3, 5 and 7 wt%)	274:310	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	8	64	theme	desirable	1091:1099	arg1	properties					1101:1110	the desirable properties	1087:1110	the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film	1087:1163	Overall, the desirable properties of the resulting PLA/ACNC/ZnO ternary composite film highlighted the potential application as a promising option for active food packaging materials.
34284052	1	65	theme	Poly	138:141	arg1	nanoparticles					257:269	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles	138:269	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%)	138:310	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
34284052	1	66	theme	cellulose	211:219	arg1	nanocrystals					221:232	acetylated cellulose nanocrystals	200:232	acetylated cellulose nanocrystals	200:232	Poly(lactic acid) (PLA)-based composite films reinforced with acetylated cellulose nanocrystals (ACNC) (1 wt%) and ZnO nanoparticles at different content (1, 3, 5 and 7 wt%) were prepared by solution-casting method.
33977873	1	0	theme	engineering	281:291	arg1	field					265:269	the field	261:269	the field of tissue engineering	261:291	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	7	1	theme	good	2000:2003	arg1	biocompatibility					2005:2020	a good biocompatibility	1998:2020	a good biocompatibility for cell adhesion and proliferation	1998:2056	Moreover, the in vitro studies revealed that the as-developed scaffolds possessed a good biocompatibility for cell adhesion and proliferation and an improved bioactivity to induce apatite formation.
33977873	4	2	theme	Scanning	1182:1189	arg1	SEM					1212:1214	SEM	1212:1214	SEM	1212:1214	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	4	2	theme	Scanning	1182:1189	arg1	microscopy					1200:1209	Scanning electron microscopy	1182:1209	Scanning electron microscopy (SEM) observation	1182:1227	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	5	3	theme	photothermal	1712:1723	arg1	efficiency					1736:1745	significantly high photothermal conversion efficiency	1693:1745	significantly high photothermal conversion efficiency	1693:1745	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	3	4	theme	multifunctional	760:774	arg1	scaffold					814:821	a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold	758:821	a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity	758:970	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	5	5	theme	light	1575:1579	arg1	NIR					1570:1572	NIR	1570:1572	NIR	1570:1572	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	5	5	theme	light	1575:1579	arg1	irradiation					1581:1591	near-infrared (NIR) light irradiation	1555:1591	near-infrared (NIR) light irradiation	1555:1591	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	3	6	theme	PLLA	1132:1135	arg1	network					1147:1153	aminated modified PLLA nanofiber network	1114:1153	aminated modified PLLA nanofiber network	1114:1153	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	4	7	theme	BP + IBU	1245:1252	arg1	microspheres					1257:1268	the BP + IBU@SA microspheres	1241:1268	the BP + IBU@SA microspheres	1241:1268	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	7	8	theme	as-developed	1965:1976	arg1	scaffolds					1978:1986	the as-developed scaffolds	1961:1986	the as-developed scaffolds	1961:1986	Moreover, the in vitro studies revealed that the as-developed scaffolds possessed a good biocompatibility for cell adhesion and proliferation and an improved bioactivity to induce apatite formation.
33977873	4	9	theme	SA	1254:1255	arg1	microspheres					1257:1268	the BP + IBU@SA microspheres	1241:1268	the BP + IBU@SA microspheres	1241:1268	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	3	10	theme	acid	796:799	arg1	scaffold					814:821	a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold	758:821	a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity	758:970	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	5	11	theme	near-infrared	1555:1567	arg1	NIR					1570:1572	NIR	1570:1572	NIR	1570:1572	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	5	11	theme	near-infrared	1555:1567	arg1	irradiation					1581:1591	near-infrared (NIR) light irradiation	1555:1591	near-infrared (NIR) light irradiation	1555:1591	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	2	12	theme	nucleation	585:594	arg1	biomineralization					617:633	the in vivo biomineralization	605:633	the in vivo biomineralization	605:633	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	2	12	theme	nucleation	585:594	arg1	sites					571:575	cell recognition sites	554:575	cell recognition sites	554:575	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	2	12	theme	nucleation	585:594	arg1	sites					596:600	the nucleation sites	581:600	the nucleation sites of the in vivo biomineralization	581:633	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	7	13	theme	in vitro	1930:1937	arg1	studies					1939:1945	the in vitro studies	1926:1945	the in vitro studies	1926:1945	Moreover, the in vitro studies revealed that the as-developed scaffolds possessed a good biocompatibility for cell adhesion and proliferation and an improved bioactivity to induce apatite formation.
33977873	0	14	theme	tissue	160:165	arg1	engineering					167:177	bone tissue engineering	155:177	bone tissue engineering	155:177	Multifunctional modified polylactic acid nanofibrous scaffold incorporating sodium alginate microspheres decorated with strontium and black phosphorus for bone tissue engineering.
33977873	2	15	theme	in vivo	609:615	arg1	biomineralization					617:633	the in vivo biomineralization	605:633	the in vivo biomineralization	605:633	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	6	16	theme	release	1869:1875	arg1	performance					1877:1887	an excellent photothermal-responsive intelligent drug release performance	1815:1887	an excellent photothermal-responsive intelligent drug release performance	1815:1887	Meanwhile, the scaffold also displayed an excellent photothermal-responsive intelligent drug release performance toward Sr2+ and ibuprofen.
33977873	3	17	theme	nanofibrous	802:812	arg1	scaffold					814:821	a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold	758:821	a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity	758:970	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	3	18	theme	anti-inflammatory	945:961	arg1	activity					963:970	anti-inflammatory activity	945:970	anti-inflammatory activity	945:970	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	6	19	theme	intelligent	1852:1862	arg1	performance					1877:1887	an excellent photothermal-responsive intelligent drug release performance	1815:1887	an excellent photothermal-responsive intelligent drug release performance	1815:1887	Meanwhile, the scaffold also displayed an excellent photothermal-responsive intelligent drug release performance toward Sr2+ and ibuprofen.
33977873	4	20	theme	PLLA	1317:1320	arg1	matrix					1322:1327	the modified PLLA matrix	1304:1327	the modified PLLA matrix with uniform nanofiber structure	1304:1360	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	6	21	theme	excellent	1818:1826	arg1	performance					1877:1887	an excellent photothermal-responsive intelligent drug release performance	1815:1887	an excellent photothermal-responsive intelligent drug release performance	1815:1887	Meanwhile, the scaffold also displayed an excellent photothermal-responsive intelligent drug release performance toward Sr2+ and ibuprofen.
33977873	0	22	theme	alginate	83:90	arg1	microspheres					92:103	sodium alginate microspheres	76:103	sodium alginate microspheres decorated with strontium and black phosphorus for bone tissue engineering	76:177	Multifunctional modified polylactic acid nanofibrous scaffold incorporating sodium alginate microspheres decorated with strontium and black phosphorus for bone tissue engineering.
33977873	1	23	theme	extracellular	367:379	arg1	ECM					389:391	ECM	389:391	ECM	389:391	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	1	23	theme	extracellular	367:379	arg1	matrix					381:386	the biomimetic extracellular matrix	352:386	the biomimetic extracellular matrix (ECM)	352:392	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	3	24	theme	anti-inflammatory	659:675	arg1	activity					677:684	effective anti-inflammatory activity	649:684	effective anti-inflammatory activity for the in vivo scaffold	649:709	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	1	25	theme	Polylactic	180:189	arg1	PLA					197:199	PLA	197:199	PLA	197:199	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	1	25	theme	Polylactic	180:189	arg1	acid					191:194	Polylactic acid	180:194	Polylactic acid (PLA) nanofibrous scaffolds	180:222	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	3	26	theme	sodium	990:995	arg1	microspheres					1006:1017	sodium alginate microspheres	990:1017	sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres)	990:1107	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	3	27	theme	drug	919:922	arg1	capacity					932:939	excellent near-infrared photothermal-responsive drug release capacity	871:939	excellent near-infrared photothermal-responsive drug release capacity	871:939	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	8	28	theme	tissue	2188:2193	arg1	applications					2207:2218	tissue engineering applications	2188:2218	tissue engineering applications	2188:2218	All these results indicated the potential of the fabricated scaffolds in tissue engineering applications.
33977873	5	29	dep	assessed	1540:1547	arg1	manifested					1606:1615	manifested	1606:1615	manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability	1606:1773	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	2	30	theme	recognition	559:569	arg1	sites					571:575	cell recognition sites	554:575	cell recognition sites	554:575	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	3	31	theme	near-infrared	881:893	arg1	capacity					932:939	excellent near-infrared photothermal-responsive drug release capacity	871:939	excellent near-infrared photothermal-responsive drug release capacity	871:939	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	4	32	theme	chemical	1370:1377	arg1	composition					1379:1389	the chemical composition	1366:1389	the chemical composition of the as-prepared scaffolds	1366:1418	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	0	33	theme	black	134:138	arg1	phosphorus					140:149	black phosphorus	134:149	black phosphorus	134:149	Multifunctional modified polylactic acid nanofibrous scaffold incorporating sodium alginate microspheres decorated with strontium and black phosphorus for bone tissue engineering.
33977873	4	34	theme	diffraction	1443:1453	arg1	XRD					1465:1467	XRD	1465:1467	XRD	1465:1467	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	4	34	theme	diffraction	1443:1453	arg1	analysis					1455:1462	X-ray diffraction analysis	1437:1462	X-ray diffraction analysis (XRD)	1437:1468	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	0	35	theme	Multifunctional	0:14	arg1	scaffold					53:60	Multifunctional modified polylactic acid nanofibrous scaffold	0:60	Multifunctional modified polylactic acid nanofibrous scaffold	0:60	Multifunctional modified polylactic acid nanofibrous scaffold incorporating sodium alginate microspheres decorated with strontium and black phosphorus for bone tissue engineering.
33977873	3	36	theme	black	1065:1069	arg1	microspheres					1095:1106	BP + IBU@SA microspheres	1083:1106	BP + IBU@SA microspheres	1083:1106	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	3	36	theme	black	1065:1069	arg1	phosphorus					1071:1080	ibuprofen-loaded black phosphorus	1048:1080	ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres)	1048:1107	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	2	37	theme	scaffolds	466:474	arg1	affinity					426:433	cell affinity	421:433	cell affinity	421:433	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	2	37	theme	scaffolds	466:474	arg1	activity					450:457	osteogenic activity	439:457	osteogenic activity	439:457	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	4	38	theme	nanofiber	1342:1350	arg1	structure					1352:1360	uniform nanofiber structure	1334:1360	uniform nanofiber structure	1334:1360	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	0	39	theme	polylactic	25:34	arg1	scaffold					53:60	Multifunctional modified polylactic acid nanofibrous scaffold	0:60	Multifunctional modified polylactic acid nanofibrous scaffold	0:60	Multifunctional modified polylactic acid nanofibrous scaffold incorporating sodium alginate microspheres decorated with strontium and black phosphorus for bone tissue engineering.
33977873	3	40	dep	strategy	738:745	arg1	develop					750:756	develop	750:756	to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network	747:1153	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	7	41	contain	possessed	1988:1996	arg2	biocompatibility					2005:2020	a good biocompatibility	1998:2020	a good biocompatibility for cell adhesion and proliferation	1998:2056	Moreover, the in vitro studies revealed that the as-developed scaffolds possessed a good biocompatibility for cell adhesion and proliferation and an improved bioactivity to induce apatite formation.
33977873	7	41	contain	possessed	1988:1996	arg2	bioactivity					2074:2084	an improved bioactivity	2062:2084	an improved bioactivity to induce apatite formation	2062:2112	Moreover, the in vitro studies revealed that the as-developed scaffolds possessed a good biocompatibility for cell adhesion and proliferation and an improved bioactivity to induce apatite formation.
33977873	7	41	contain	possessed	1988:1996	arg1	scaffolds					1978:1986	the as-developed scaffolds	1961:1986	the as-developed scaffolds	1961:1986	Moreover, the in vitro studies revealed that the as-developed scaffolds possessed a good biocompatibility for cell adhesion and proliferation and an improved bioactivity to induce apatite formation.
33977873	2	42	theme	osteogenic	439:448	arg1	activity					450:457	osteogenic activity	439:457	osteogenic activity	439:457	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	0	43	theme	nanofibrous	41:51	arg1	scaffold					53:60	Multifunctional modified polylactic acid nanofibrous scaffold	0:60	Multifunctional modified polylactic acid nanofibrous scaffold	0:60	Multifunctional modified polylactic acid nanofibrous scaffold incorporating sodium alginate microspheres decorated with strontium and black phosphorus for bone tissue engineering.
33977873	3	44	theme	@	1091:1091	arg1	microspheres					1095:1106	BP + IBU@SA microspheres	1083:1106	BP + IBU@SA microspheres	1083:1106	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	3	44	theme	@	1091:1091	arg1	phosphorus					1071:1080	ibuprofen-loaded black phosphorus	1048:1080	ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres)	1048:1107	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	5	45	theme	BP	1640:1641	arg1	entrapment					1626:1635	the entrapment	1622:1635	the entrapment of BP	1622:1641	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	3	46	theme	in vivo	694:700	arg1	scaffold					702:709	the in vivo scaffold	690:709	the in vivo scaffold	690:709	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	7	47	theme	cell	2026:2029	arg1	adhesion					2031:2038	cell adhesion	2026:2038	cell adhesion	2026:2038	Moreover, the in vitro studies revealed that the as-developed scaffolds possessed a good biocompatibility for cell adhesion and proliferation and an improved bioactivity to induce apatite formation.
33977873	4	48	theme	as-prepared	1398:1408	arg1	scaffolds					1410:1418	the as-prepared scaffolds	1394:1418	the as-prepared scaffolds	1394:1418	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	2	49	dep	affinity	426:433	arg1	the					417:419	the	417:419	the	417:419	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	5	50	theme	cycle	1759:1763	arg1	stability					1765:1773	optical cycle stability	1751:1773	optical cycle stability	1751:1773	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	1	51	theme	tissue	274:279	arg1	engineering					281:291	tissue engineering	274:291	tissue engineering	274:291	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	3	52	theme	nanofiber	1137:1145	arg1	network					1147:1153	aminated modified PLLA nanofiber network	1114:1153	aminated modified PLLA nanofiber network	1114:1153	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	4	53	theme	electron	1191:1198	arg1	SEM					1212:1214	SEM	1212:1214	SEM	1212:1214	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	4	53	theme	electron	1191:1198	arg1	microscopy					1200:1209	Scanning electron microscopy	1182:1209	Scanning electron microscopy (SEM) observation	1182:1227	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	5	54	theme	high	1707:1710	arg1	efficiency					1736:1745	significantly high photothermal conversion efficiency	1693:1745	significantly high photothermal conversion efficiency	1693:1745	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	4	55	theme	elemental	1474:1482	arg1	mapping					1484:1490	elemental mapping	1474:1490	elemental mapping	1474:1490	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	5	56	dep	PLLA	1662:1665	arg1	nanofibrous					1667:1677	nanofibrous	1667:1677	nanofibrous	1667:1677	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	2	57	theme	biomineralization	617:633	arg1	biomineralization					617:633	the in vivo biomineralization	605:633	the in vivo biomineralization	605:633	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	2	57	theme	biomineralization	617:633	arg1	absence					543:549	the absence	539:549	the absence of cell recognition sites	539:575	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	2	57	theme	biomineralization	617:633	arg1	hydrophobicity					523:536	their intrinsic hydrophobicity	507:536	their intrinsic hydrophobicity	507:536	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	2	57	theme	biomineralization	617:633	arg1	sites					596:600	the nucleation sites	581:600	the nucleation sites of the in vivo biomineralization	581:633	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	2	57	theme	biomineralization	617:633	arg1	sites					571:575	cell recognition sites	554:575	cell recognition sites	554:575	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	3	58	theme	modified	1123:1130	arg1	network					1147:1153	aminated modified PLLA nanofiber network	1114:1153	aminated modified PLLA nanofiber network	1114:1153	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	4	59	theme	@	1253:1253	arg1	microspheres					1257:1268	the BP + IBU@SA microspheres	1241:1268	the BP + IBU@SA microspheres	1241:1268	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	8	60	from	potential	2147:2155	arg1	applications					2207:2218	tissue engineering applications	2188:2218	tissue engineering applications	2188:2218	All these results indicated the potential of the fabricated scaffolds in tissue engineering applications.
33977873	5	61	theme	conversion	1725:1734	arg1	efficiency					1736:1745	significantly high photothermal conversion efficiency	1693:1745	significantly high photothermal conversion efficiency	1693:1745	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	3	62	theme	PLLA	776:779	arg1	scaffold					814:821	a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold	758:821	a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity	758:970	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	5	63	with	endowed	1654:1660	arg1	efficiency					1736:1745	significantly high photothermal conversion efficiency	1693:1745	significantly high photothermal conversion efficiency	1693:1745	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	5	63	with	endowed	1654:1660	arg1	stability					1765:1773	optical cycle stability	1751:1773	optical cycle stability	1751:1773	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	5	64	dep	nanosheets	1643:1652	arg1	endowed					1654:1660	endowed	1654:1660	endowed	1654:1660	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	1	65	theme	nanofibrous	202:212	arg1	scaffolds					214:222	Polylactic acid (PLA) nanofibrous scaffolds	180:222	Polylactic acid (PLA) nanofibrous scaffolds	180:222	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	8	66	theme	scaffolds	2175:2183	arg1	potential					2147:2155	the potential	2143:2155	the potential of the fabricated scaffolds in tissue engineering applications	2143:2218	All these results indicated the potential of the fabricated scaffolds in tissue engineering applications.
33977873	0	67	theme	bone	155:158	arg1	engineering					167:177	bone tissue engineering	155:177	bone tissue engineering	155:177	Multifunctional modified polylactic acid nanofibrous scaffold incorporating sodium alginate microspheres decorated with strontium and black phosphorus for bone tissue engineering.
33977873	3	68	theme	poly-L-lactic	782:794	arg1	scaffold					814:821	a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold	758:821	a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity	758:970	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	1	69	theme	extensive	238:246	arg1	attention					248:256	extensive attention	238:256	extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies	238:405	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	2	70	theme	sites	571:575	arg1	biomineralization					617:633	the in vivo biomineralization	605:633	the in vivo biomineralization	605:633	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	2	70	theme	sites	571:575	arg1	absence					543:549	the absence	539:549	the absence of cell recognition sites	539:575	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	2	70	theme	sites	571:575	arg1	hydrophobicity					523:536	their intrinsic hydrophobicity	507:536	their intrinsic hydrophobicity	507:536	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	2	70	theme	sites	571:575	arg1	sites					596:600	the nucleation sites	581:600	the nucleation sites of the in vivo biomineralization	581:633	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	2	70	theme	sites	571:575	arg1	sites					571:575	cell recognition sites	554:575	cell recognition sites	554:575	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	4	71	theme	modified	1308:1315	arg1	matrix					1322:1327	the modified PLLA matrix	1304:1327	the modified PLLA matrix with uniform nanofiber structure	1304:1360	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	1	72	from	attention	248:256	arg1	field					265:269	the field	261:269	the field of tissue engineering	261:291	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	6	73	theme	drug	1864:1867	arg1	performance					1877:1887	an excellent photothermal-responsive intelligent drug release performance	1815:1887	an excellent photothermal-responsive intelligent drug release performance	1815:1887	Meanwhile, the scaffold also displayed an excellent photothermal-responsive intelligent drug release performance toward Sr2+ and ibuprofen.
33977873	8	74	theme	fabricated	2164:2173	arg1	scaffolds					2175:2183	the fabricated scaffolds	2160:2183	the fabricated scaffolds	2160:2183	All these results indicated the potential of the fabricated scaffolds in tissue engineering applications.
33977873	6	75	theme	photothermal-responsive	1828:1850	arg1	performance					1877:1887	an excellent photothermal-responsive intelligent drug release performance	1815:1887	an excellent photothermal-responsive intelligent drug release performance	1815:1887	Meanwhile, the scaffold also displayed an excellent photothermal-responsive intelligent drug release performance toward Sr2+ and ibuprofen.
33977873	3	76	theme	excellent	871:879	arg1	capacity					932:939	excellent near-infrared photothermal-responsive drug release capacity	871:939	excellent near-infrared photothermal-responsive drug release capacity	871:939	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	3	77	theme	effective	649:657	arg1	activity					677:684	effective anti-inflammatory activity	649:684	effective anti-inflammatory activity for the in vivo scaffold	649:709	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	1	78	dep	degradability	316:328	arg1	topographies					394:405	topographies	394:405	topographies	394:405	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	8	79	theme	engineering	2195:2205	arg1	applications					2207:2218	tissue engineering applications	2188:2218	tissue engineering applications	2188:2218	All these results indicated the potential of the fabricated scaffolds in tissue engineering applications.
33977873	1	80	theme	acid	191:194	arg1	scaffolds					214:222	Polylactic acid (PLA) nanofibrous scaffolds	180:222	Polylactic acid (PLA) nanofibrous scaffolds	180:222	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	3	81	theme	alginate	997:1004	arg1	microspheres					1006:1017	sodium alginate microspheres	990:1017	sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres)	990:1107	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	2	82	theme	intrinsic	513:521	arg1	hydrophobicity					523:536	their intrinsic hydrophobicity	507:536	their intrinsic hydrophobicity	507:536	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	3	83	theme	release	924:930	arg1	capacity					932:939	excellent near-infrared photothermal-responsive drug release capacity	871:939	excellent near-infrared photothermal-responsive drug release capacity	871:939	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	3	84	with	scaffold	814:821	arg1	capacity					932:939	excellent near-infrared photothermal-responsive drug release capacity	871:939	excellent near-infrared photothermal-responsive drug release capacity	871:939	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	3	84	with	scaffold	814:821	arg1	activity					963:970	anti-inflammatory activity	945:970	anti-inflammatory activity	945:970	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	3	84	with	scaffold	814:821	arg1	osteoinductivity					853:868	osteoinductivity	853:868	osteoinductivity	853:868	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	3	84	with	scaffold	814:821	arg1	improved hydrophilicity					828:850	improved hydrophilicity	828:850	improved hydrophilicity	828:850	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	2	85	theme	cell	554:557	arg1	sites					571:575	cell recognition sites	554:575	cell recognition sites	554:575	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	3	86	theme	photothermal-responsive	895:917	arg1	capacity					932:939	excellent near-infrared photothermal-responsive drug release capacity	871:939	excellent near-infrared photothermal-responsive drug release capacity	871:939	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	4	87	theme	uniform	1334:1340	arg1	structure					1352:1360	uniform nanofiber structure	1334:1360	uniform nanofiber structure	1334:1360	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	2	88	theme	cell	421:424	arg1	affinity					426:433	cell affinity	421:433	cell affinity	421:433	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	0	89	theme	modified	16:23	arg1	scaffold					53:60	Multifunctional modified polylactic acid nanofibrous scaffold	0:60	Multifunctional modified polylactic acid nanofibrous scaffold	0:60	Multifunctional modified polylactic acid nanofibrous scaffold incorporating sodium alginate microspheres decorated with strontium and black phosphorus for bone tissue engineering.
33977873	0	90	theme	acid	36:39	arg1	scaffold					53:60	Multifunctional modified polylactic acid nanofibrous scaffold	0:60	Multifunctional modified polylactic acid nanofibrous scaffold	0:60	Multifunctional modified polylactic acid nanofibrous scaffold incorporating sodium alginate microspheres decorated with strontium and black phosphorus for bone tissue engineering.
33977873	1	91	theme	excellent	306:314	arg1	degradability					316:328	their excellent degradability	300:328	their excellent degradability	300:328	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	2	92	theme	PLA	462:464	arg1	scaffolds					466:474	PLA scaffolds	462:474	PLA scaffolds	462:474	However, the cell affinity and osteogenic activity of PLA scaffolds is not satisfactory because of their intrinsic hydrophobicity, the absence of cell recognition sites and the nucleation sites of the in vivo biomineralization.
33977873	7	93	theme	apatite	2096:2102	arg1	formation					2104:2112	apatite formation	2096:2112	apatite formation	2096:2112	Moreover, the in vitro studies revealed that the as-developed scaffolds possessed a good biocompatibility for cell adhesion and proliferation and an improved bioactivity to induce apatite formation.
33977873	3	94	theme	ibuprofen-loaded	1048:1063	arg1	microspheres					1095:1106	BP + IBU@SA microspheres	1083:1106	BP + IBU@SA microspheres	1083:1106	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	3	94	theme	ibuprofen-loaded	1048:1063	arg1	phosphorus					1071:1080	ibuprofen-loaded black phosphorus	1048:1080	ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres)	1048:1107	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	4	95	theme	X-ray	1437:1441	arg1	XRD					1465:1467	XRD	1465:1467	XRD	1465:1467	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	4	95	theme	X-ray	1437:1441	arg1	analysis					1455:1462	X-ray diffraction analysis	1437:1462	X-ray diffraction analysis (XRD)	1437:1468	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	0	96	theme	sodium	76:81	arg1	microspheres					92:103	sodium alginate microspheres	76:103	sodium alginate microspheres decorated with strontium and black phosphorus for bone tissue engineering	76:177	Multifunctional modified polylactic acid nanofibrous scaffold incorporating sodium alginate microspheres decorated with strontium and black phosphorus for bone tissue engineering.
33977873	3	97	theme	SA	1092:1093	arg1	microspheres					1095:1106	BP + IBU@SA microspheres	1083:1106	BP + IBU@SA microspheres	1083:1106	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	3	97	theme	SA	1092:1093	arg1	phosphorus					1071:1080	ibuprofen-loaded black phosphorus	1048:1080	ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres)	1048:1107	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	5	98	theme	scaffolds	1526:1534	arg1	property					1510:1517	The photothermal property	1493:1517	The photothermal property of the scaffolds	1493:1534	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	1	99	theme	biomimetic	356:365	arg1	ECM					389:391	ECM	389:391	ECM	389:391	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	1	99	theme	biomimetic	356:365	arg1	matrix					381:386	the biomimetic extracellular matrix	352:386	the biomimetic extracellular matrix (ECM)	352:392	Polylactic acid (PLA) nanofibrous scaffolds have received extensive attention in the field of tissue engineering due to their excellent degradability, biocompatibility and the biomimetic extracellular matrix (ECM) topographies.
33977873	7	100	theme	improved	2065:2072	arg1	bioactivity					2074:2084	an improved bioactivity	2062:2084	an improved bioactivity to induce apatite formation	2062:2112	Moreover, the in vitro studies revealed that the as-developed scaffolds possessed a good biocompatibility for cell adhesion and proliferation and an improved bioactivity to induce apatite formation.
33977873	3	101	theme	BP + IBU	1083:1090	arg1	microspheres					1095:1106	BP + IBU@SA microspheres	1083:1106	BP + IBU@SA microspheres	1083:1106	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	3	101	theme	BP + IBU	1083:1090	arg1	phosphorus					1071:1080	ibuprofen-loaded black phosphorus	1048:1080	ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres)	1048:1107	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	4	102	theme	microscopy	1200:1209	arg1	observation					1217:1227	Scanning electron microscopy (SEM) observation	1182:1227	Scanning electron microscopy (SEM) observation	1182:1227	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	5	103	theme	PLLA	1662:1665	arg1	scaffold					1679:1686	PLLA nanofibrous scaffold	1662:1686	PLLA nanofibrous scaffold	1662:1686	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	4	104	theme	scaffolds	1410:1418	arg1	composition					1379:1389	the chemical composition	1366:1389	the chemical composition of the as-prepared scaffolds	1366:1418	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	4	105	with	matrix	1322:1327	arg1	structure					1352:1360	uniform nanofiber structure	1334:1360	uniform nanofiber structure	1334:1360	Scanning electron microscopy (SEM) observation showed that the BP + IBU@SA microspheres were homogeneously dispersed into the modified PLLA matrix with uniform nanofiber structure and the chemical composition of the as-prepared scaffolds was confirmed by X-ray diffraction analysis (XRD) and elemental mapping.
33977873	3	106	theme	aminated	1114:1121	arg1	network					1147:1153	aminated modified PLLA nanofiber network	1114:1153	aminated modified PLLA nanofiber network	1114:1153	Furthermore, effective anti-inflammatory activity for the in vivo scaffold could not be ignored, so a strategy to develop a multifunctional PLLA (poly-L-lactic acid) nanofibrous scaffold with improved hydrophilicity, osteoinductivity, excellent near-infrared photothermal-responsive drug release capacity and anti-inflammatory activity via incorporating sodium alginate microspheres decorated with strontium and ibuprofen-loaded black phosphorus (BP + IBU@SA microspheres) into aminated modified PLLA nanofiber network is proposed in this study.
33977873	5	107	theme	optical	1751:1757	arg1	stability					1765:1773	optical cycle stability	1751:1773	optical cycle stability	1751:1773	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
33977873	5	108	theme	photothermal	1497:1508	arg1	property					1510:1517	The photothermal property	1493:1517	The photothermal property of the scaffolds	1493:1534	The photothermal property of the scaffolds was assessed under near-infrared (NIR) light irradiation, the results manifested that the entrapment of BP nanosheets endowed PLLA nanofibrous scaffold with significantly high photothermal conversion efficiency and optical cycle stability.
32396152	2	0	theme	ratios	374:379	arg1	conditions					321:330	varied acidic conditions	307:330	varied acidic conditions of sol-gel reaction and inorganic/organic ratios	307:379	The effects of varied acidic conditions of sol-gel reaction and inorganic/organic ratios on the performance of the hybrid were investigated.
32396152	5	1	theme	latter	923:928	arg1	conditions					930:939	the latter conditions	919:939	the latter conditions	919:939	Under the latter conditions, the interactions between silica and chitosan were weak.
32396152	2	2	theme	inorganic/organic	356:372	arg1	ratios					374:379	inorganic/organic ratios	356:379	inorganic/organic ratios	356:379	The effects of varied acidic conditions of sol-gel reaction and inorganic/organic ratios on the performance of the hybrid were investigated.
32396152	8	3	theme	chitosan-silica	1327:1341	arg1	hybrids					1343:1349	chitosan-silica hybrids	1327:1349	chitosan-silica hybrids	1327:1349	These results suggested that the weak acidic sol-gel process were essential for fabricating chitosan-silica hybrids with high mechanical strength, which had potential to be applied as a bone substitute.
32396152	3	4	from	MPa	615:617	arg1	forms					634:638	wet and dry forms	622:638	wet and dry forms	622:638	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	3	5	theme	homogeneous	510:520	arg1	nanostructure					522:534	a homogeneous nanostructure	508:534	a homogeneous nanostructure	508:534	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	6	6	theme	mechanical	1012:1021	arg1	properties					1023:1032	the mechanical properties	1008:1032	the mechanical properties of the CSHs	1008:1044	Moreover, the mechanical properties of the CSHs could be tuned in a wide range by conveniently varying the inorganic/organic composition ratio between 50% and 70%.
32396152	4	7	theme	compressive	853:863	arg1	strength					865:872	compressive strength	853:872	compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8	853:909	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	3	8	theme	maximum	557:563	arg1	strength					577:584	maximum compressive strength	557:584	maximum compressive strength	557:584	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	3	9	dep	strength	577:584	arg1	MPa					615:617	271 ± 31 MPa	606:617	271 ± 31 MPa	606:617	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	3	9	dep	strength	577:584	arg1	MPa					598:600	42.6 ± 3.3 MPa	587:600	42.6 ± 3.3 MPa	587:600	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	6	10	theme	CSHs	1041:1044	arg1	properties					1023:1032	the mechanical properties	1008:1032	the mechanical properties of the CSHs	1008:1044	Moreover, the mechanical properties of the CSHs could be tuned in a wide range by conveniently varying the inorganic/organic composition ratio between 50% and 70%.
32396152	1	11	theme	bone	273:276	arg1	regeneration					278:289	bone regeneration	273:289	bone regeneration	273:289	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
32396152	4	12	theme	6.3	875:877	arg1	±					879:879	±	879:879	±	879:879	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	8	13	theme	acidic	1273:1278	arg1	essential					1301:1309	essential	1301:1309	essential	1301:1309	These results suggested that the weak acidic sol-gel process were essential for fabricating chitosan-silica hybrids with high mechanical strength, which had potential to be applied as a bone substitute.
32396152	8	13	theme	acidic	1273:1278	arg1	process					1288:1294	the weak acidic sol-gel process	1264:1294	the weak acidic sol-gel process	1264:1294	These results suggested that the weak acidic sol-gel process were essential for fabricating chitosan-silica hybrids with high mechanical strength, which had potential to be applied as a bone substitute.
32396152	4	14	theme	acidic	698:703	arg1	condition					705:713	the strong acidic condition	687:713	the strong acidic condition (HCl, pH 4.0)	687:727	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	1	15	theme	homogeneous	163:173	arg1	dispersion					175:184	homogeneous dispersion	163:184	homogeneous dispersion	163:184	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
32396152	0	16	theme	Robust	0:5	arg1	hybrids					42:48	Robust and nanostructured chitosan-silica hybrids	0:48	Robust and nanostructured chitosan-silica hybrids	0:48	Robust and nanostructured chitosan-silica hybrids for bone repair application.
32396152	3	17	theme	acidic	461:466	arg1	conditions					468:477	weak acidic conditions	456:477	weak acidic conditions (acetic acid, pH 4.0)	456:499	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	6	18	theme	composition	1123:1133	arg1	ratio					1135:1139	the inorganic/organic composition ratio	1101:1139	the inorganic/organic composition ratio	1101:1139	Moreover, the mechanical properties of the CSHs could be tuned in a wide range by conveniently varying the inorganic/organic composition ratio between 50% and 70%.
32396152	4	19	dep	exhibited	811:819	arg1	strength					865:872	compressive strength	853:872	compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8	853:909	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	2	20	theme	conditions	321:330	arg1	effects					296:302	The effects	292:302	The effects of varied acidic conditions of sol-gel reaction and inorganic/organic ratios on the performance of the hybrid	292:412	The effects of varied acidic conditions of sol-gel reaction and inorganic/organic ratios on the performance of the hybrid were investigated.
32396152	7	21	theme	cytocompatibility	1171:1187	arg1	study					1189:1193	In vitro cytocompatibility study	1162:1193	In vitro cytocompatibility study	1162:1193	In vitro cytocompatibility study indicated that CSHs were non-cytotoxic.
32396152	1	22	with	hybrids	110:116	arg1	strength					150:157	superior mechanical strength	130:157	superior mechanical strength	130:157	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
32396152	1	22	with	hybrids	110:116	arg1	dispersion					175:184	homogeneous dispersion	163:184	homogeneous dispersion	163:184	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
32396152	8	23	theme	substitute	1426:1435	arg1	bone					1421:1424	a bone	1419:1424	a bone substitute	1419:1435	These results suggested that the weak acidic sol-gel process were essential for fabricating chitosan-silica hybrids with high mechanical strength, which had potential to be applied as a bone substitute.
32396152	6	24	theme	inorganic/organic	1105:1121	arg1	ratio					1135:1139	the inorganic/organic composition ratio	1101:1139	the inorganic/organic composition ratio	1101:1139	Moreover, the mechanical properties of the CSHs could be tuned in a wide range by conveniently varying the inorganic/organic composition ratio between 50% and 70%.
32396152	2	25	theme	acidic	314:319	arg1	conditions					321:330	varied acidic conditions	307:330	varied acidic conditions of sol-gel reaction and inorganic/organic ratios	307:379	The effects of varied acidic conditions of sol-gel reaction and inorganic/organic ratios on the performance of the hybrid were investigated.
32396152	1	26	theme	nano-sized	189:198	arg1	particles					207:215	nano-sized silica particles	189:215	nano-sized silica particles	189:215	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
32396152	0	27	theme	chitosan-silica	26:40	arg1	hybrids					42:48	Robust and nanostructured chitosan-silica hybrids	0:48	Robust and nanostructured chitosan-silica hybrids	0:48	Robust and nanostructured chitosan-silica hybrids for bone repair application.
32396152	4	28	theme	strong	691:696	arg1	condition					705:713	the strong acidic condition	687:713	the strong acidic condition (HCl, pH 4.0)	687:727	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	4	29	theme	mechanical	830:839	arg1	properties					841:850	inferior mechanical properties	821:850	inferior mechanical properties	821:850	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	3	30	theme	±	592:592	arg1	MPa					598:600	42.6 ± 3.3 MPa	587:600	42.6 ± 3.3 MPa	587:600	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	2	31	theme	varied	307:312	arg1	conditions					321:330	varied acidic conditions	307:330	varied acidic conditions of sol-gel reaction and inorganic/organic ratios	307:379	The effects of varied acidic conditions of sol-gel reaction and inorganic/organic ratios on the performance of the hybrid were investigated.
32396152	1	32	theme	silica	200:205	arg1	particles					207:215	nano-sized silica particles	189:215	nano-sized silica particles	189:215	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
32396152	0	33	theme	nanostructured	11:24	arg1	hybrids					42:48	Robust and nanostructured chitosan-silica hybrids	0:48	Robust and nanostructured chitosan-silica hybrids	0:48	Robust and nanostructured chitosan-silica hybrids for bone repair application.
32396152	4	34	theme	inferior	821:828	arg1	properties					841:850	inferior mechanical properties	821:850	inferior mechanical properties	821:850	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	3	35	theme	wet	622:624	arg1	forms					634:638	wet and dry forms	622:638	wet and dry forms	622:638	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	3	36	theme	compressive	565:575	arg1	strength					577:584	maximum compressive strength	557:584	maximum compressive strength	557:584	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	1	37	theme	particles	207:215	arg1	strength					150:157	superior mechanical strength	130:157	superior mechanical strength	130:157	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
32396152	1	37	theme	particles	207:215	arg1	dispersion					175:184	homogeneous dispersion	163:184	homogeneous dispersion	163:184	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
32396152	4	38	dep	condition	705:713	arg1	pH					721:722	pH 4.0	721:726	pH 4.0	721:726	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	4	38	dep	condition	705:713	arg1	HCl					716:718	HCl	716:718	HCl	716:718	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	4	39	dep	strength	865:872	arg1	MPa					885:887	6.3 ± 0.3 MPa	875:887	compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8	853:909	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	8	40	theme	weak	1268:1271	arg1	essential					1301:1309	essential	1301:1309	essential	1301:1309	These results suggested that the weak acidic sol-gel process were essential for fabricating chitosan-silica hybrids with high mechanical strength, which had potential to be applied as a bone substitute.
32396152	8	40	theme	weak	1268:1271	arg1	process					1288:1294	the weak acidic sol-gel process	1264:1294	the weak acidic sol-gel process	1264:1294	These results suggested that the weak acidic sol-gel process were essential for fabricating chitosan-silica hybrids with high mechanical strength, which had potential to be applied as a bone substitute.
32396152	3	41	from	MPa	598:600	arg1	forms					634:638	wet and dry forms	622:638	wet and dry forms	622:638	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	2	42	theme	hybrid	407:412	arg1	performance					388:398	the performance	384:398	the performance of the hybrid	384:412	The effects of varied acidic conditions of sol-gel reaction and inorganic/organic ratios on the performance of the hybrid were investigated.
32396152	4	43	from	pH	904:905	arg1	MPa					885:887	6.3 ± 0.3 MPa	875:887	compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8	853:909	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	4	44	theme	wet	892:894	arg1	form					896:899	wet form	892:899	wet form	892:899	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	4	45	theme	acid	744:747	arg1	condition					749:757	the strong acid condition	733:757	the strong acid condition	733:757	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	8	46	contain	had	1388:1390	arg1	strength					1372:1379	high mechanical strength	1356:1379	high mechanical strength	1356:1379	These results suggested that the weak acidic sol-gel process were essential for fabricating chitosan-silica hybrids with high mechanical strength, which had potential to be applied as a bone substitute.
32396152	8	46	contain	had	1388:1390	arg2	potential					1392:1400	potential	1392:1400	potential to be applied as a bone substitute	1392:1435	These results suggested that the weak acidic sol-gel process were essential for fabricating chitosan-silica hybrids with high mechanical strength, which had potential to be applied as a bone substitute.
32396152	0	47	theme	repair	59:64	arg1	application					66:76	bone repair application	54:76	bone repair application	54:76	Robust and nanostructured chitosan-silica hybrids for bone repair application.
32396152	3	48	theme	weak	456:459	arg1	conditions					468:477	weak acidic conditions	456:477	weak acidic conditions (acetic acid, pH 4.0)	456:499	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	4	49	theme	lower	764:768	arg1	HCl					774:776	HCl	774:776	HCl	774:776	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	4	49	theme	lower	764:768	arg1	pH					770:771	lower pH	764:771	lower pH (HCl, pH 2.8)	764:785	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	0	50	theme	bone	54:57	arg1	application					66:76	bone repair application	54:76	bone repair application	54:76	Robust and nanostructured chitosan-silica hybrids for bone repair application.
32396152	8	51	theme	sol-gel	1280:1286	arg1	essential					1301:1309	essential	1301:1309	essential	1301:1309	These results suggested that the weak acidic sol-gel process were essential for fabricating chitosan-silica hybrids with high mechanical strength, which had potential to be applied as a bone substitute.
32396152	8	51	theme	sol-gel	1280:1286	arg1	process					1288:1294	the weak acidic sol-gel process	1264:1294	the weak acidic sol-gel process	1264:1294	These results suggested that the weak acidic sol-gel process were essential for fabricating chitosan-silica hybrids with high mechanical strength, which had potential to be applied as a bone substitute.
32396152	7	52	dep	In	1162:1163	arg1	vitro					1165:1169	vitro	1165:1169	vitro	1165:1169	In vitro cytocompatibility study indicated that CSHs were non-cytotoxic.
32396152	0	53	dep	hybrids	42:48	arg1	application					66:76	bone repair application	54:76	bone repair application	54:76	Robust and nanostructured chitosan-silica hybrids for bone repair application.
32396152	2	54	theme	reaction	343:350	arg1	conditions					321:330	varied acidic conditions	307:330	varied acidic conditions of sol-gel reaction and inorganic/organic ratios	307:379	The effects of varied acidic conditions of sol-gel reaction and inorganic/organic ratios on the performance of the hybrid were investigated.
32396152	4	55	from	MPa	885:887	arg1	form					896:899	wet form	892:899	wet form	892:899	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	3	56	dep	conditions	468:477	arg1	pH					493:494	pH 4.0	493:498	pH 4.0	493:498	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	3	56	dep	conditions	468:477	arg1	acid					487:490	acetic acid	480:490	acetic acid	480:490	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	3	57	theme	±	610:610	arg1	MPa					615:617	271 ± 31 MPa	606:617	271 ± 31 MPa	606:617	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	8	58	theme	mechanical	1361:1370	arg1	strength					1372:1379	high mechanical strength	1356:1379	high mechanical strength	1356:1379	These results suggested that the weak acidic sol-gel process were essential for fabricating chitosan-silica hybrids with high mechanical strength, which had potential to be applied as a bone substitute.
32396152	2	59	theme	sol-gel	335:341	arg1	reaction					343:350	sol-gel reaction	335:350	sol-gel reaction	335:350	The effects of varied acidic conditions of sol-gel reaction and inorganic/organic ratios on the performance of the hybrid were investigated.
32396152	1	60	theme	chitosan-silica	94:108	arg1	CSHs					119:122	CSHs	119:122	CSHs	119:122	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
32396152	1	60	theme	chitosan-silica	94:108	arg1	hybrids					110:116	chitosan-silica hybrids	94:116	chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles	94:215	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
32396152	3	61	theme	robust	540:545	arg1	strength					547:554	robust strength	540:554	robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively)	540:653	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	3	62	theme	dry	630:632	arg1	forms					634:638	wet and dry forms	622:638	wet and dry forms	622:638	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	6	63	theme	wide	1066:1069	arg1	range					1071:1075	a wide range	1064:1075	a wide range by conveniently varying the inorganic/organic composition ratio between 50% and 70%	1064:1159	Moreover, the mechanical properties of the CSHs could be tuned in a wide range by conveniently varying the inorganic/organic composition ratio between 50% and 70%.
32396152	8	64	theme	high	1356:1359	arg1	strength					1372:1379	high mechanical strength	1356:1379	high mechanical strength	1356:1379	These results suggested that the weak acidic sol-gel process were essential for fabricating chitosan-silica hybrids with high mechanical strength, which had potential to be applied as a bone substitute.
32396152	2	65	from	effects	296:302	arg1	performance					388:398	the performance	384:398	the performance of the hybrid	384:412	The effects of varied acidic conditions of sol-gel reaction and inorganic/organic ratios on the performance of the hybrid were investigated.
32396152	3	66	dep	strength	547:554	arg1	strength					577:584	maximum compressive strength	557:584	maximum compressive strength	557:584	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	4	67	theme	0.3	881:883	arg1	±					879:879	±	879:879	±	879:879	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	4	68	theme	strong	737:742	arg1	condition					749:757	the strong acid condition	733:757	the strong acid condition	733:757	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	3	69	theme	acetic	480:485	arg1	pH					493:494	pH 4.0	493:498	pH 4.0	493:498	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	3	69	theme	acetic	480:485	arg1	acid					487:490	acetic acid	480:490	acetic acid	480:490	CSHs synthesized under weak acidic conditions (acetic acid, pH 4.0) showed a homogeneous nanostructure and robust strength (maximum compressive strength: 42.6 ± 3.3 MPa and 271 ± 31 MPa in wet and dry forms, respectively).
32396152	1	70	theme	superior	130:137	arg1	strength					150:157	superior mechanical strength	130:157	superior mechanical strength	130:157	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
32396152	7	71	theme	In	1162:1163	arg1	study					1189:1193	In vitro cytocompatibility study	1162:1193	In vitro cytocompatibility study	1162:1193	In vitro cytocompatibility study indicated that CSHs were non-cytotoxic.
32396152	1	72	theme	facile	240:245	arg1	method					255:260	a facile sol-gel method	238:260	a facile sol-gel method aiming for bone regeneration	238:289	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
32396152	4	73	dep	HCl	774:776	arg1	pH					779:780	pH 2.8	779:784	pH 2.8	779:784	However, those developed under the strong acidic condition (HCl, pH 4.0) and the strong acid condition plus lower pH (HCl, pH 2.8) tended to aggregate and exhibited inferior mechanical properties (compressive strength: 6.3 ± 0.3 MPa in wet form at pH 2.8).
32396152	1	74	theme	mechanical	139:148	arg1	strength					150:157	superior mechanical strength	130:157	superior mechanical strength	130:157	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
32396152	1	75	theme	sol-gel	247:253	arg1	method					255:260	a facile sol-gel method	238:260	a facile sol-gel method aiming for bone regeneration	238:289	In this study, chitosan-silica hybrids (CSHs) with superior mechanical strength and homogeneous dispersion of nano-sized silica particles were synthesized via a facile sol-gel method aiming for bone regeneration.
33527931	8	0	theme	Cell	1156:1159	arg1	experiments					1161:1171	Cell experiments	1156:1171	Cell experiments	1156:1171	Cell experiments showed that scaffolds with PDA under irradiation could suppress the tumor effectively.
33527931	6	1	theme	osteogenic	913:922	arg1	differentiation					924:938	more osteogenic differentiation	908:938	more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs)	908:982	HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process.
33527931	10	2	theme	tumor	1495:1499	arg1	proliferation					1506:1518	tumor cell proliferation	1495:1518	tumor cell proliferation	1495:1518	Vascular injury was developed subsequently, which lead to the suppression of tumor cell proliferation due to hypoxia-ischemia.
33527931	11	3	theme	multiple	1582:1589	arg1	effects					1591:1597	multiple effects	1582:1597	multiple effects	1582:1597	HA/PDA/CMCS composite scaffolds with multiple effects have great potential application in bone tumor therapy.
33527931	1	4	theme	bone	270:273	arg1	defects					275:281	large bone defects	264:281	large bone defects	264:281	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
33527931	5	5	theme	anti-tumor	771:780	arg1	effects					782:788	anti-tumor effects	771:788	anti-tumor effects	771:788	The photothermal properties and anti-tumor effects of the scaffolds in vivo were assessed by the tumor model in nude mice.
33527931	7	6	theme	excellent	1121:1129	arg1	properties					1144:1153	excellent photothermal properties	1121:1153	excellent photothermal properties	1121:1153	The PDA-modified composite scaffold had excellent photothermal properties.
33527931	11	7	theme	great	1604:1608	arg1	application					1620:1630	great potential application	1604:1630	great potential application	1604:1630	HA/PDA/CMCS composite scaffolds with multiple effects have great potential application in bone tumor therapy.
33527931	1	8	theme	bone	192:195	arg1	properties					204:213	anti-tumor and bone repair properties	177:213	properties	204:213	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
33527931	11	9	theme	composite	1557:1565	arg1	scaffolds					1567:1575	HA/PDA/CMCS composite scaffolds	1545:1575	HA/PDA/CMCS composite scaffolds with multiple effects	1545:1597	HA/PDA/CMCS composite scaffolds with multiple effects have great potential application in bone tumor therapy.
33527931	5	10	dep	in	807:808	arg1	vivo					810:813	vivo	810:813	vivo	810:813	The photothermal properties and anti-tumor effects of the scaffolds in vivo were assessed by the tumor model in nude mice.
33527931	11	11	theme	potential	1610:1618	arg1	application					1620:1630	great potential application	1604:1630	great potential application	1604:1630	HA/PDA/CMCS composite scaffolds with multiple effects have great potential application in bone tumor therapy.
33527931	3	12	theme	mechanical	534:543	arg1	properties					545:554	mechanical properties	534:554	mechanical properties	534:554	PDA significantly improved the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds.
33527931	11	13	with	scaffolds	1567:1575	arg1	effects					1591:1597	multiple effects	1582:1597	multiple effects	1582:1597	HA/PDA/CMCS composite scaffolds with multiple effects have great potential application in bone tumor therapy.
33527931	9	14	theme	HA/PDA/CMCS	1319:1329	arg1	scaffold					1341:1348	the HA/PDA/CMCS composite scaffold	1315:1348	the HA/PDA/CMCS composite scaffold	1315:1348	In vivo anti-tumor effects in nude mice indicated that the HA/PDA/CMCS composite scaffold promoted cell apoptosis/necrosis by the direct photothermal effect.
33527931	9	15	theme	photothermal	1397:1408	arg1	effect					1410:1415	the direct photothermal effect	1386:1415	the direct photothermal effect	1386:1415	In vivo anti-tumor effects in nude mice indicated that the HA/PDA/CMCS composite scaffold promoted cell apoptosis/necrosis by the direct photothermal effect.
33527931	9	16	theme	composite	1331:1339	arg1	scaffold					1341:1348	the HA/PDA/CMCS composite scaffold	1315:1348	the HA/PDA/CMCS composite scaffold	1315:1348	In vivo anti-tumor effects in nude mice indicated that the HA/PDA/CMCS composite scaffold promoted cell apoptosis/necrosis by the direct photothermal effect.
33527931	6	17	theme	photothermal	1059:1070	arg1	process					1072:1078	the photothermal process	1055:1078	the photothermal process	1055:1078	HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process.
33527931	1	18	theme	repair	197:202	arg1	properties					204:213	anti-tumor and bone repair properties	177:213	properties	204:213	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
33527931	7	19	theme	photothermal	1131:1142	arg1	properties					1144:1153	excellent photothermal properties	1121:1153	excellent photothermal properties	1121:1153	The PDA-modified composite scaffold had excellent photothermal properties.
33527931	6	20	theme	composite	874:882	arg1	scaffolds					884:892	HA/PDA/CMCS composite scaffolds	862:892	HA/PDA/CMCS composite scaffolds	862:892	HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process.
33527931	1	21	with	scaffold	163:170	arg1	properties					204:213	anti-tumor and bone repair properties	177:213	properties	204:213	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
33527931	8	22	with	scaffolds	1185:1193	arg1	PDA					1200:1202	PDA	1200:1202	PDA	1200:1202	Cell experiments showed that scaffolds with PDA under irradiation could suppress the tumor effectively.
33527931	3	23	theme	slurry	514:519	arg1	properties					496:505	the rheological properties	480:505	the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds	480:627	PDA significantly improved the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds.
33527931	9	24	theme	In	1260:1261	arg1	effects					1279:1285	In vivo anti-tumor effects	1260:1285	In vivo anti-tumor effects in nude mice	1260:1298	In vivo anti-tumor effects in nude mice indicated that the HA/PDA/CMCS composite scaffold promoted cell apoptosis/necrosis by the direct photothermal effect.
33527931	4	25	theme	osteogenic	634:643	arg1	properties					645:654	The osteogenic properties	630:654	The osteogenic properties of HA/PDA/CMCS composite scaffolds	630:689	The osteogenic properties of HA/PDA/CMCS composite scaffolds were evaluated by the cell experiment in vitro.
33527931	5	26	theme	in	807:808	arg1	scaffolds					797:805	the scaffolds	793:805	the scaffolds in vivo	793:813	The photothermal properties and anti-tumor effects of the scaffolds in vivo were assessed by the tumor model in nude mice.
33527931	6	27	theme	HA/PDA/CMCS	862:872	arg1	scaffolds					884:892	HA/PDA/CMCS composite scaffolds	862:892	HA/PDA/CMCS composite scaffolds	862:892	HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process.
33527931	10	28	theme	cell	1501:1504	arg1	proliferation					1506:1518	tumor cell proliferation	1495:1518	tumor cell proliferation	1495:1518	Vascular injury was developed subsequently, which lead to the suppression of tumor cell proliferation due to hypoxia-ischemia.
33527931	11	29	theme	tumor	1640:1644	arg1	therapy					1646:1652	bone tumor therapy	1635:1652	bone tumor therapy	1635:1652	HA/PDA/CMCS composite scaffolds with multiple effects have great potential application in bone tumor therapy.
33527931	4	30	theme	HA/PDA/CMCS	659:669	arg1	scaffolds					681:689	HA/PDA/CMCS composite scaffolds	659:689	HA/PDA/CMCS composite scaffolds	659:689	The osteogenic properties of HA/PDA/CMCS composite scaffolds were evaluated by the cell experiment in vitro.
33527931	0	31	theme	Bifunctional	0:11	arg1	scaffolds					13:21	Bifunctional scaffolds	0:21	Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect.	0:125	Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect.
33527931	9	32	theme	cell	1359:1362	arg1	apoptosis/necrosis					1364:1381	cell apoptosis/necrosis	1359:1381	cell apoptosis/necrosis	1359:1381	In vivo anti-tumor effects in nude mice indicated that the HA/PDA/CMCS composite scaffold promoted cell apoptosis/necrosis by the direct photothermal effect.
33527931	9	33	theme	nude	1290:1293	arg1	mice					1295:1298	nude mice	1290:1298	nude mice	1290:1298	In vivo anti-tumor effects in nude mice indicated that the HA/PDA/CMCS composite scaffold promoted cell apoptosis/necrosis by the direct photothermal effect.
33527931	0	34	dep	osteogenesis	84:95	arg1	effect					119:124	effect	119:124	effect	119:124	Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect.
33527931	11	35	contain	have	1599:1602	arg1	scaffolds					1567:1575	HA/PDA/CMCS composite scaffolds	1545:1575	HA/PDA/CMCS composite scaffolds with multiple effects	1545:1597	HA/PDA/CMCS composite scaffolds with multiple effects have great potential application in bone tumor therapy.
33527931	11	35	contain	have	1599:1602	arg2	application					1620:1630	great potential application	1604:1630	great potential application	1604:1630	HA/PDA/CMCS composite scaffolds with multiple effects have great potential application in bone tumor therapy.
33527931	0	36	theme	hydroxyapatite/poly	26:44	arg1	chitosan					70:77	hydroxyapatite/poly(dopamine)/carboxymethyl chitosan	26:77	hydroxyapatite/poly(dopamine)/carboxymethyl chitosan	26:77	Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect.
33527931	10	37	theme	Vascular	1418:1425	arg1	injury					1427:1432	Vascular injury	1418:1432	Vascular injury	1418:1432	Vascular injury was developed subsequently, which lead to the suppression of tumor cell proliferation due to hypoxia-ischemia.
33527931	2	38	theme	hydroxyapatite	311:324	arg1	scaffolds					398:406	hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds	311:406	hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds	311:406	In this study, hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds were prepared by the 3D-printing technology.
33527931	7	39	theme	PDA-modified	1085:1096	arg1	scaffold					1108:1115	The PDA-modified composite scaffold	1081:1115	The PDA-modified composite scaffold	1081:1115	The PDA-modified composite scaffold had excellent photothermal properties.
33527931	2	40	theme	composite	388:396	arg1	scaffolds					398:406	hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds	311:406	hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds	311:406	In this study, hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds were prepared by the 3D-printing technology.
33527931	6	41	theme	cells	969:973	arg1	differentiation					924:938	more osteogenic differentiation	908:938	more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs)	908:982	HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process.
33527931	9	42	from	effects	1279:1285	arg1	mice					1295:1298	nude mice	1290:1298	nude mice	1290:1298	In vivo anti-tumor effects in nude mice indicated that the HA/PDA/CMCS composite scaffold promoted cell apoptosis/necrosis by the direct photothermal effect.
33527931	3	43	theme	rheological	484:494	arg1	properties					496:505	the rheological properties	480:505	the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds	480:627	PDA significantly improved the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds.
33527931	0	44	theme	dopamine	46:53	arg1	chitosan					70:77	hydroxyapatite/poly(dopamine)/carboxymethyl chitosan	26:77	hydroxyapatite/poly(dopamine)/carboxymethyl chitosan	26:77	Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect.
33527931	2	45	theme	poly	332:335	arg1	scaffolds					398:406	hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds	311:406	hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds	311:406	In this study, hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds were prepared by the 3D-printing technology.
33527931	6	46	theme	stromal	961:967	arg1	cells					969:973	mouse bone marrow stromal cells	943:973	mouse bone marrow stromal cells (mBMSCs)	943:982	HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process.
33527931	6	46	theme	stromal	961:967	arg1	mBMSCs					976:981	mBMSCs	976:981	mBMSCs	976:981	HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process.
33527931	10	47	theme	proliferation	1506:1518	arg1	suppression					1480:1490	the suppression	1476:1490	the suppression of tumor cell proliferation due to hypoxia-ischemia	1476:1542	Vascular injury was developed subsequently, which lead to the suppression of tumor cell proliferation due to hypoxia-ischemia.
33527931	5	48	theme	tumor	836:840	arg1	model					842:846	the tumor model	832:846	the tumor model in nude mice	832:859	The photothermal properties and anti-tumor effects of the scaffolds in vivo were assessed by the tumor model in nude mice.
33527931	2	49	theme	carboxymethyl	358:370	arg1	CMCS					382:385	CMCS	382:385	CMCS	382:385	In this study, hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds were prepared by the 3D-printing technology.
33527931	2	49	theme	carboxymethyl	358:370	arg1	chitosan					372:379	carboxymethyl chitosan	358:379	carboxymethyl chitosan (CMCS)	358:386	In this study, hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds were prepared by the 3D-printing technology.
33527931	6	50	theme	marrow	954:959	arg1	cells					969:973	mouse bone marrow stromal cells	943:973	mouse bone marrow stromal cells (mBMSCs)	943:982	HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process.
33527931	6	50	theme	marrow	954:959	arg1	mBMSCs					976:981	mBMSCs	976:981	mBMSCs	976:981	HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process.
33527931	2	51	theme	3D-printing	429:439	arg1	technology					441:450	the 3D-printing technology	425:450	the 3D-printing technology	425:450	In this study, hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds were prepared by the 3D-printing technology.
33527931	3	52	theme	composite	609:617	arg1	scaffolds					619:627	composite scaffolds	609:627	composite scaffolds	609:627	PDA significantly improved the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds.
33527931	9	53	dep	In	1260:1261	arg1	vivo					1263:1266	vivo	1263:1266	vivo	1263:1266	In vivo anti-tumor effects in nude mice indicated that the HA/PDA/CMCS composite scaffold promoted cell apoptosis/necrosis by the direct photothermal effect.
33527931	2	54	theme	chitosan	372:379	arg1	scaffolds					398:406	hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds	311:406	hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds	311:406	In this study, hydroxyapatite (HA), poly(dopamine) (PDA), and carboxymethyl chitosan (CMCS) composite scaffolds were prepared by the 3D-printing technology.
33527931	0	55	theme	/carboxymethyl	55:68	arg1	chitosan					70:77	hydroxyapatite/poly(dopamine)/carboxymethyl chitosan	26:77	hydroxyapatite/poly(dopamine)/carboxymethyl chitosan	26:77	Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect.
33527931	6	56	theme	bone	949:952	arg1	cells					969:973	mouse bone marrow stromal cells	943:973	mouse bone marrow stromal cells (mBMSCs)	943:982	HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process.
33527931	6	56	theme	bone	949:952	arg1	mBMSCs					976:981	mBMSCs	976:981	mBMSCs	976:981	HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process.
33527931	3	57	theme	scaffolds	619:627	arg1	potential					574:582	surface relative potential	557:582	surface relative potential	557:582	PDA significantly improved the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds.
33527931	3	57	theme	scaffolds	619:627	arg1	absorption					595:604	water absorption	589:604	water absorption	589:604	PDA significantly improved the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds.
33527931	3	57	theme	scaffolds	619:627	arg1	molding					525:531	molding	525:531	molding	525:531	PDA significantly improved the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds.
33527931	3	57	theme	scaffolds	619:627	arg1	properties					545:554	mechanical properties	534:554	mechanical properties	534:554	PDA significantly improved the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds.
33527931	3	58	theme	surface	557:563	arg1	potential					574:582	surface relative potential	557:582	surface relative potential	557:582	PDA significantly improved the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds.
33527931	5	59	from	model	842:846	arg1	mice					856:859	nude mice	851:859	nude mice	851:859	The photothermal properties and anti-tumor effects of the scaffolds in vivo were assessed by the tumor model in nude mice.
33527931	1	60	theme	bifunctional	131:142	arg1	scaffold					163:170	The bifunctional tissue engineering scaffold	127:170	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties	127:213	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
33527931	1	60	theme	bifunctional	131:142	arg1	promising					218:226	promising	218:226	promising	218:226	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
33527931	5	61	theme	scaffolds	797:805	arg1	properties					756:765	photothermal properties	743:765	photothermal properties	743:765	The photothermal properties and anti-tumor effects of the scaffolds in vivo were assessed by the tumor model in nude mice.
33527931	5	61	theme	scaffolds	797:805	arg1	effects					782:788	anti-tumor effects	771:788	anti-tumor effects	771:788	The photothermal properties and anti-tumor effects of the scaffolds in vivo were assessed by the tumor model in nude mice.
33527931	6	62	theme	mouse	943:947	arg1	cells					969:973	mouse bone marrow stromal cells	943:973	mouse bone marrow stromal cells (mBMSCs)	943:982	HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process.
33527931	6	62	theme	mouse	943:947	arg1	mBMSCs					976:981	mBMSCs	976:981	mBMSCs	976:981	HA/PDA/CMCS composite scaffolds could promote more osteogenic differentiation of mouse bone marrow stromal cells (mBMSCs) than scaffolds without PDA in vitro and the effect was not hindered by the photothermal process.
33527931	9	63	theme	anti-tumor	1268:1277	arg1	effects					1279:1285	In vivo anti-tumor effects	1260:1285	In vivo anti-tumor effects in nude mice	1260:1298	In vivo anti-tumor effects in nude mice indicated that the HA/PDA/CMCS composite scaffold promoted cell apoptosis/necrosis by the direct photothermal effect.
33527931	3	64	theme	relative	565:572	arg1	potential					574:582	surface relative potential	557:582	surface relative potential	557:582	PDA significantly improved the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds.
33527931	0	65	with	scaffolds	13:21	arg1	osteogenesis					84:95	osteogenesis	84:95	osteogenesis	84:95	Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect.
33527931	0	65	with	scaffolds	13:21	arg1	anti-osteosarcoma					101:117	anti-osteosarcoma	101:117	anti-osteosarcoma	101:117	Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect.
33527931	1	66	theme	tissue	144:149	arg1	scaffold					163:170	The bifunctional tissue engineering scaffold	127:170	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties	127:213	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
33527931	1	66	theme	tissue	144:149	arg1	promising					218:226	promising	218:226	promising	218:226	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
33527931	5	67	dep	properties	756:765	arg1	The					739:741	The	739:741	The	739:741	The photothermal properties and anti-tumor effects of the scaffolds in vivo were assessed by the tumor model in nude mice.
33527931	11	68	theme	bone	1635:1638	arg1	therapy					1646:1652	bone tumor therapy	1635:1652	bone tumor therapy	1635:1652	HA/PDA/CMCS composite scaffolds with multiple effects have great potential application in bone tumor therapy.
33527931	4	69	theme	composite	671:679	arg1	scaffolds					681:689	HA/PDA/CMCS composite scaffolds	659:689	HA/PDA/CMCS composite scaffolds	659:689	The osteogenic properties of HA/PDA/CMCS composite scaffolds were evaluated by the cell experiment in vitro.
33527931	1	70	theme	engineering	151:161	arg1	scaffold					163:170	The bifunctional tissue engineering scaffold	127:170	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties	127:213	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
33527931	1	70	theme	engineering	151:161	arg1	promising					218:226	promising	218:226	promising	218:226	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
33527931	11	71	theme	HA/PDA/CMCS	1545:1555	arg1	scaffolds					1567:1575	HA/PDA/CMCS composite scaffolds	1545:1575	HA/PDA/CMCS composite scaffolds with multiple effects	1545:1597	HA/PDA/CMCS composite scaffolds with multiple effects have great potential application in bone tumor therapy.
33527931	1	72	theme	bone	247:250	arg1	tumor					252:256	bone tumor	247:256	bone tumor where large bone defects often occur	247:293	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
33527931	7	73	theme	composite	1098:1106	arg1	scaffold					1108:1115	The PDA-modified composite scaffold	1081:1115	The PDA-modified composite scaffold	1081:1115	The PDA-modified composite scaffold had excellent photothermal properties.
33527931	4	74	theme	cell	713:716	arg1	experiment					718:727	the cell experiment	709:727	the cell experiment	709:727	The osteogenic properties of HA/PDA/CMCS composite scaffolds were evaluated by the cell experiment in vitro.
33527931	9	75	theme	direct	1390:1395	arg1	effect					1410:1415	the direct photothermal effect	1386:1415	the direct photothermal effect	1386:1415	In vivo anti-tumor effects in nude mice indicated that the HA/PDA/CMCS composite scaffold promoted cell apoptosis/necrosis by the direct photothermal effect.
33527931	1	76	theme	tumor	252:256	arg1	therapy					236:242	the therapy	232:242	the therapy of bone tumor where large bone defects often occur	232:293	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
33527931	5	77	theme	photothermal	743:754	arg1	properties					756:765	photothermal properties	743:765	photothermal properties	743:765	The photothermal properties and anti-tumor effects of the scaffolds in vivo were assessed by the tumor model in nude mice.
33527931	7	78	contain	had	1117:1119	arg1	scaffold					1108:1115	The PDA-modified composite scaffold	1081:1115	The PDA-modified composite scaffold	1081:1115	The PDA-modified composite scaffold had excellent photothermal properties.
33527931	7	78	contain	had	1117:1119	arg2	properties					1144:1153	excellent photothermal properties	1121:1153	excellent photothermal properties	1121:1153	The PDA-modified composite scaffold had excellent photothermal properties.
33527931	4	79	theme	scaffolds	681:689	arg1	properties					645:654	The osteogenic properties	630:654	The osteogenic properties of HA/PDA/CMCS composite scaffolds	630:689	The osteogenic properties of HA/PDA/CMCS composite scaffolds were evaluated by the cell experiment in vitro.
33527931	5	80	theme	nude	851:854	arg1	mice					856:859	nude mice	851:859	nude mice	851:859	The photothermal properties and anti-tumor effects of the scaffolds in vivo were assessed by the tumor model in nude mice.
33527931	0	81	theme	chitosan	70:77	arg1	scaffolds					13:21	Bifunctional scaffolds	0:21	Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect.	0:125	Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect.
33527931	3	82	theme	water	589:593	arg1	absorption					595:604	water absorption	589:604	water absorption	589:604	PDA significantly improved the rheological properties of the slurry for molding, mechanical properties, surface relative potential, and water absorption of composite scaffolds.
33527931	1	83	theme	anti-tumor	177:186	arg1	properties					204:213	anti-tumor and bone repair properties	177:213	properties	204:213	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
33527931	1	84	theme	large	264:268	arg1	defects					275:281	large bone defects	264:281	large bone defects	264:281	The bifunctional tissue engineering scaffold with anti-tumor and bone repair properties is promising for the therapy of bone tumor where large bone defects often occur.
34537654	1	0	theme	material	239:246	arg1	reuse					217:221	the reuse	213:221	the reuse of waste cotton material	213:246	In this work, a porous multi-functional biomass carbon was prepared by acid-base modification method, which realized the reuse of waste cotton material.
34537654	3	1	theme	adsorption	517:526	arg1	performance					528:538	the adsorption performance	513:538	the adsorption performance of the adsorbent	513:555	This not only increases the adsorption performance of the adsorbent but also improves the stability of hydrogel.
34537654	5	2	theme	selective	973:981	arg1	adsorption					983:992	stronger selective adsorption	964:992	stronger selective adsorption	964:992	Meanwhile, the adsorbent would have a strong chemical interaction with Pb2+ and Cu2+, can form a stable chelating structure, and showed stronger selective adsorption.
34537654	7	3	theme	adsorption	1345:1354	arg1	reaction					1356:1363	the adsorption reaction	1341:1363	the adsorption reaction	1341:1363	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	4	4	dep	pollutants	672:681	arg1	1105.78 mg g-1					684:697	1105.78 mg g-1	684:697	1105.78 mg g-1 for Pb2+, 678.04 mg g-1 for Cu2+, and 590.72 mg g-1 for methylene blue (MB)	684:773	These characteristics provide high-efficiency adsorption capacity for pollutants (1105.78 mg g-1 for Pb2+, 678.04 mg g-1 for Cu2+, and 590.72 mg g-1 for methylene blue (MB)), which is far superior to most reported adsorbents.
34537654	6	5	theme	rate-limiting	1184:1196	arg1	reaction					1227:1234	a chemical chelation reaction	1206:1234	a chemical chelation reaction	1206:1234	The adsorption process is more suitable for the Langmuir isotherm and follows a pseudo-second-order kinetic model, which indicates that the adsorption is a single-layer adsorption, and the rate-limiting step is a chemical chelation reaction.
34537654	6	5	theme	rate-limiting	1184:1196	arg1	step					1198:1201	the rate-limiting step	1180:1201	the rate-limiting step	1180:1201	The adsorption process is more suitable for the Langmuir isotherm and follows a pseudo-second-order kinetic model, which indicates that the adsorption is a single-layer adsorption, and the rate-limiting step is a chemical chelation reaction.
34537654	8	6	theme	adsorption	1389:1398	arg1	capacity					1400:1407	the adsorption capacity	1385:1407	the adsorption capacity of the adsorbent	1385:1424	After five cycles, the adsorption capacity of the adsorbent and the recovery of heavy metal ions remained at a high level.
34537654	5	7	theme	stable	925:930	arg1	structure					942:950	a stable chelating structure	923:950	a stable chelating structure	923:950	Meanwhile, the adsorbent would have a strong chemical interaction with Pb2+ and Cu2+, can form a stable chelating structure, and showed stronger selective adsorption.
34537654	2	8	with	composite	401:409	arg1	acid					457:460	ethylenediamine tetraacetic acid	429:460	ethylenediamine tetraacetic acid	429:460	Then, the modified biochar was combined with the acrylic-based hydrogel by radical polymerization, and the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid was successfully prepared.
34537654	2	8	with	composite	401:409	arg1	chitosan					416:423	chitosan	416:423	chitosan	416:423	Then, the modified biochar was combined with the acrylic-based hydrogel by radical polymerization, and the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid was successfully prepared.
34537654	6	9	theme	Langmuir	1043:1050	arg1	isotherm					1052:1059	the Langmuir isotherm	1039:1059	the Langmuir isotherm	1039:1059	The adsorption process is more suitable for the Langmuir isotherm and follows a pseudo-second-order kinetic model, which indicates that the adsorption is a single-layer adsorption, and the rate-limiting step is a chemical chelation reaction.
34537654	2	10	theme	modified	259:266	arg1	biochar					268:274	the modified biochar	255:274	the modified biochar	255:274	Then, the modified biochar was combined with the acrylic-based hydrogel by radical polymerization, and the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid was successfully prepared.
34537654	2	11	theme	hydrogel	378:385	arg1	composite					401:409	the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite	352:409	the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid	352:460	Then, the modified biochar was combined with the acrylic-based hydrogel by radical polymerization, and the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid was successfully prepared.
34537654	2	12	theme	CS/EDTA/CBC	388:398	arg1	composite					401:409	the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite	352:409	the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid	352:460	Then, the modified biochar was combined with the acrylic-based hydrogel by radical polymerization, and the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid was successfully prepared.
34537654	6	13	theme	adsorption	999:1008	arg1	process					1010:1016	The adsorption process	995:1016	The adsorption process	995:1016	The adsorption process is more suitable for the Langmuir isotherm and follows a pseudo-second-order kinetic model, which indicates that the adsorption is a single-layer adsorption, and the rate-limiting step is a chemical chelation reaction.
34537654	6	13	theme	adsorption	999:1008	arg1	suitable					1026:1033	suitable	1026:1033	suitable	1026:1033	The adsorption process is more suitable for the Langmuir isotherm and follows a pseudo-second-order kinetic model, which indicates that the adsorption is a single-layer adsorption, and the rate-limiting step is a chemical chelation reaction.
34537654	5	14	contain	have	859:862	arg2	interaction					882:892	a strong chemical interaction	864:892	a strong chemical interaction with Pb2+ and Cu2+	864:911	Meanwhile, the adsorbent would have a strong chemical interaction with Pb2+ and Cu2+, can form a stable chelating structure, and showed stronger selective adsorption.
34537654	5	14	contain	have	859:862	arg1	Meanwhile					828:836	Meanwhile	828:836	Meanwhile	828:836	Meanwhile, the adsorbent would have a strong chemical interaction with Pb2+ and Cu2+, can form a stable chelating structure, and showed stronger selective adsorption.
34537654	5	14	contain	have	859:862	arg1	adsorbent					843:851	adsorbent	843:851	adsorbent	843:851	Meanwhile, the adsorbent would have a strong chemical interaction with Pb2+ and Cu2+, can form a stable chelating structure, and showed stronger selective adsorption.
34537654	0	15	theme	Functionalized	0:13	arg1	charcoal/chitosan					22:38	Functionalized cotton charcoal/chitosan	0:38	Functionalized cotton charcoal/chitosan	0:38	Functionalized cotton charcoal/chitosan biomass-based hydrogel for capturing Pb2+, Cu2+ and MB.
34537654	1	16	theme	acid-base	167:175	arg1	method					190:195	acid-base modification method	167:195	acid-base modification method	167:195	In this work, a porous multi-functional biomass carbon was prepared by acid-base modification method, which realized the reuse of waste cotton material.
34537654	0	17	theme	cotton	15:20	arg1	charcoal/chitosan					22:38	Functionalized cotton charcoal/chitosan	0:38	Functionalized cotton charcoal/chitosan	0:38	Functionalized cotton charcoal/chitosan biomass-based hydrogel for capturing Pb2+, Cu2+ and MB.
34537654	2	18	theme	acrylic-based	298:310	arg1	hydrogel					312:319	the acrylic-based hydrogel	294:319	the acrylic-based hydrogel by radical polymerization	294:345	Then, the modified biochar was combined with the acrylic-based hydrogel by radical polymerization, and the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid was successfully prepared.
34537654	1	19	theme	modification	177:188	arg1	method					190:195	acid-base modification method	167:195	acid-base modification method	167:195	In this work, a porous multi-functional biomass carbon was prepared by acid-base modification method, which realized the reuse of waste cotton material.
34537654	2	20	theme	tetraacetic	445:455	arg1	acid					457:460	ethylenediamine tetraacetic acid	429:460	ethylenediamine tetraacetic acid	429:460	Then, the modified biochar was combined with the acrylic-based hydrogel by radical polymerization, and the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid was successfully prepared.
34537654	5	21	theme	chelating	932:940	arg1	structure					942:950	a stable chelating structure	923:950	a stable chelating structure	923:950	Meanwhile, the adsorbent would have a strong chemical interaction with Pb2+ and Cu2+, can form a stable chelating structure, and showed stronger selective adsorption.
34537654	2	22	theme	acrylic-based	364:376	arg1	composite					401:409	the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite	352:409	the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid	352:460	Then, the modified biochar was combined with the acrylic-based hydrogel by radical polymerization, and the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid was successfully prepared.
34537654	2	23	theme	ethylenediamine	429:443	arg1	acid					457:460	ethylenediamine tetraacetic acid	429:460	ethylenediamine tetraacetic acid	429:460	Then, the modified biochar was combined with the acrylic-based hydrogel by radical polymerization, and the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid was successfully prepared.
34537654	8	24	theme	heavy	1446:1450	arg1	ions					1458:1461	heavy metal ions	1446:1461	heavy metal ions	1446:1461	After five cycles, the adsorption capacity of the adsorbent and the recovery of heavy metal ions remained at a high level.
34537654	8	25	theme	adsorbent	1416:1424	arg1	recovery					1434:1441	the recovery	1430:1441	the recovery of heavy metal ions	1430:1461	After five cycles, the adsorption capacity of the adsorbent and the recovery of heavy metal ions remained at a high level.
34537654	8	25	theme	adsorbent	1416:1424	arg1	capacity					1400:1407	the adsorption capacity	1385:1407	the adsorption capacity of the adsorbent	1385:1424	After five cycles, the adsorption capacity of the adsorbent and the recovery of heavy metal ions remained at a high level.
34537654	7	26	theme	main	1322:1325	arg1	mechanisms					1327:1336	the main mechanisms	1318:1336	the main mechanisms of the adsorption reaction	1318:1363	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	7	26	theme	main	1322:1325	arg1	complexation					1272:1283	surface complexation	1264:1283	surface complexation	1264:1283	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	7	26	theme	main	1322:1325	arg1	attraction					1303:1312	electrostatic attraction	1289:1312	electrostatic attraction	1289:1312	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	6	27	theme	single-layer	1151:1162	arg1	adsorption					1164:1173	a single-layer adsorption	1149:1173	a single-layer adsorption	1149:1173	The adsorption process is more suitable for the Langmuir isotherm and follows a pseudo-second-order kinetic model, which indicates that the adsorption is a single-layer adsorption, and the rate-limiting step is a chemical chelation reaction.
34537654	6	27	theme	single-layer	1151:1162	arg1	adsorption					1135:1144	the adsorption	1131:1144	the adsorption	1131:1144	The adsorption process is more suitable for the Langmuir isotherm and follows a pseudo-second-order kinetic model, which indicates that the adsorption is a single-layer adsorption, and the rate-limiting step is a chemical chelation reaction.
34537654	5	28	theme	stronger	964:971	arg1	adsorption					983:992	stronger selective adsorption	964:992	stronger selective adsorption	964:992	Meanwhile, the adsorbent would have a strong chemical interaction with Pb2+ and Cu2+, can form a stable chelating structure, and showed stronger selective adsorption.
34537654	8	29	theme	ions	1458:1461	arg1	recovery					1434:1441	the recovery	1430:1441	the recovery of heavy metal ions	1430:1461	After five cycles, the adsorption capacity of the adsorbent and the recovery of heavy metal ions remained at a high level.
34537654	8	29	theme	ions	1458:1461	arg1	capacity					1400:1407	the adsorption capacity	1385:1407	the adsorption capacity of the adsorbent	1385:1424	After five cycles, the adsorption capacity of the adsorbent and the recovery of heavy metal ions remained at a high level.
34537654	6	30	theme	kinetic	1095:1101	arg1	model					1103:1107	a pseudo-second-order kinetic model	1073:1107	a pseudo-second-order kinetic model	1073:1107	The adsorption process is more suitable for the Langmuir isotherm and follows a pseudo-second-order kinetic model, which indicates that the adsorption is a single-layer adsorption, and the rate-limiting step is a chemical chelation reaction.
34537654	1	31	theme	biomass	136:142	arg1	carbon					144:149	a porous multi-functional biomass carbon	110:149	a porous multi-functional biomass carbon	110:149	In this work, a porous multi-functional biomass carbon was prepared by acid-base modification method, which realized the reuse of waste cotton material.
34537654	8	32	theme	metal	1452:1456	arg1	ions					1458:1461	heavy metal ions	1446:1461	heavy metal ions	1446:1461	After five cycles, the adsorption capacity of the adsorbent and the recovery of heavy metal ions remained at a high level.
34537654	6	33	theme	pseudo-second-order	1075:1093	arg1	model					1103:1107	a pseudo-second-order kinetic model	1073:1107	a pseudo-second-order kinetic model	1073:1107	The adsorption process is more suitable for the Langmuir isotherm and follows a pseudo-second-order kinetic model, which indicates that the adsorption is a single-layer adsorption, and the rate-limiting step is a chemical chelation reaction.
34537654	5	34	theme	chemical	873:880	arg1	interaction					882:892	a strong chemical interaction	864:892	a strong chemical interaction with Pb2+ and Cu2+	864:911	Meanwhile, the adsorbent would have a strong chemical interaction with Pb2+ and Cu2+, can form a stable chelating structure, and showed stronger selective adsorption.
34537654	3	35	theme	hydrogel	592:599	arg1	stability					579:587	the stability	575:587	the stability of hydrogel	575:599	This not only increases the adsorption performance of the adsorbent but also improves the stability of hydrogel.
34537654	7	36	theme	electrostatic	1289:1301	arg1	mechanisms					1327:1336	the main mechanisms	1318:1336	the main mechanisms of the adsorption reaction	1318:1363	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	7	36	theme	electrostatic	1289:1301	arg1	complexation					1272:1283	surface complexation	1264:1283	surface complexation	1264:1283	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	7	36	theme	electrostatic	1289:1301	arg1	attraction					1303:1312	electrostatic attraction	1289:1312	electrostatic attraction	1289:1312	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	5	37	with	interaction	882:892	arg1	Cu2+					908:911	Cu2+	908:911	Cu2+	908:911	Meanwhile, the adsorbent would have a strong chemical interaction with Pb2+ and Cu2+, can form a stable chelating structure, and showed stronger selective adsorption.
34537654	5	37	with	interaction	882:892	arg1	Pb2+					899:902	Pb2+	899:902	Pb2+	899:902	Meanwhile, the adsorbent would have a strong chemical interaction with Pb2+ and Cu2+, can form a stable chelating structure, and showed stronger selective adsorption.
34537654	8	38	theme	high	1477:1480	arg1	level					1482:1486	a high level	1475:1486	a high level	1475:1486	After five cycles, the adsorption capacity of the adsorbent and the recovery of heavy metal ions remained at a high level.
34537654	6	39	theme	chelation	1217:1225	arg1	reaction					1227:1234	a chemical chelation reaction	1206:1234	a chemical chelation reaction	1206:1234	The adsorption process is more suitable for the Langmuir isotherm and follows a pseudo-second-order kinetic model, which indicates that the adsorption is a single-layer adsorption, and the rate-limiting step is a chemical chelation reaction.
34537654	6	39	theme	chelation	1217:1225	arg1	step					1198:1201	the rate-limiting step	1180:1201	the rate-limiting step	1180:1201	The adsorption process is more suitable for the Langmuir isotherm and follows a pseudo-second-order kinetic model, which indicates that the adsorption is a single-layer adsorption, and the rate-limiting step is a chemical chelation reaction.
34537654	7	40	theme	reaction	1356:1363	arg1	mechanisms					1327:1336	the main mechanisms	1318:1336	the main mechanisms of the adsorption reaction	1318:1363	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	7	40	theme	reaction	1356:1363	arg1	complexation					1272:1283	surface complexation	1264:1283	surface complexation	1264:1283	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	7	40	theme	reaction	1356:1363	arg1	attraction					1303:1312	electrostatic attraction	1289:1312	electrostatic attraction	1289:1312	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	2	41	theme	radical	324:330	arg1	polymerization					332:345	radical polymerization	324:345	radical polymerization	324:345	Then, the modified biochar was combined with the acrylic-based hydrogel by radical polymerization, and the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid was successfully prepared.
34537654	6	42	theme	chemical	1208:1215	arg1	reaction					1227:1234	a chemical chelation reaction	1206:1234	a chemical chelation reaction	1206:1234	The adsorption process is more suitable for the Langmuir isotherm and follows a pseudo-second-order kinetic model, which indicates that the adsorption is a single-layer adsorption, and the rate-limiting step is a chemical chelation reaction.
34537654	6	42	theme	chemical	1208:1215	arg1	step					1198:1201	the rate-limiting step	1180:1201	the rate-limiting step	1180:1201	The adsorption process is more suitable for the Langmuir isotherm and follows a pseudo-second-order kinetic model, which indicates that the adsorption is a single-layer adsorption, and the rate-limiting step is a chemical chelation reaction.
34537654	1	43	theme	porous	112:117	arg1	carbon					144:149	a porous multi-functional biomass carbon	110:149	a porous multi-functional biomass carbon	110:149	In this work, a porous multi-functional biomass carbon was prepared by acid-base modification method, which realized the reuse of waste cotton material.
34537654	4	44	theme	high-efficiency	632:646	arg1	capacity					659:666	high-efficiency adsorption capacity	632:666	high-efficiency adsorption capacity	632:666	These characteristics provide high-efficiency adsorption capacity for pollutants (1105.78 mg g-1 for Pb2+, 678.04 mg g-1 for Cu2+, and 590.72 mg g-1 for methylene blue (MB)), which is far superior to most reported adsorbents.
34537654	3	45	theme	adsorbent	547:555	arg1	performance					528:538	the adsorption performance	513:538	the adsorption performance of the adsorbent	513:555	This not only increases the adsorption performance of the adsorbent but also improves the stability of hydrogel.
34537654	1	46	theme	multi-functional	119:134	arg1	carbon					144:149	a porous multi-functional biomass carbon	110:149	a porous multi-functional biomass carbon	110:149	In this work, a porous multi-functional biomass carbon was prepared by acid-base modification method, which realized the reuse of waste cotton material.
34537654	4	47	theme	blue	765:768	arg1	methylene					755:763	methylene blue	755:768	methylene blue (MB)	755:773	These characteristics provide high-efficiency adsorption capacity for pollutants (1105.78 mg g-1 for Pb2+, 678.04 mg g-1 for Cu2+, and 590.72 mg g-1 for methylene blue (MB)), which is far superior to most reported adsorbents.
34537654	4	47	theme	blue	765:768	arg1	MB					771:772	MB	771:772	MB	771:772	These characteristics provide high-efficiency adsorption capacity for pollutants (1105.78 mg g-1 for Pb2+, 678.04 mg g-1 for Cu2+, and 590.72 mg g-1 for methylene blue (MB)), which is far superior to most reported adsorbents.
34537654	4	48	theme	reported	807:814	arg1	adsorbents					816:825	most reported adsorbents	802:825	most reported adsorbents	802:825	These characteristics provide high-efficiency adsorption capacity for pollutants (1105.78 mg g-1 for Pb2+, 678.04 mg g-1 for Cu2+, and 590.72 mg g-1 for methylene blue (MB)), which is far superior to most reported adsorbents.
34537654	2	49	theme	biochar	356:362	arg1	composite					401:409	the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite	352:409	the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid	352:460	Then, the modified biochar was combined with the acrylic-based hydrogel by radical polymerization, and the biochar acrylic-based hydrogel (CS/EDTA/CBC) composite with chitosan and ethylenediamine tetraacetic acid was successfully prepared.
34537654	5	50	theme	strong	866:871	arg1	interaction					882:892	a strong chemical interaction	864:892	a strong chemical interaction with Pb2+ and Cu2+	864:911	Meanwhile, the adsorbent would have a strong chemical interaction with Pb2+ and Cu2+, can form a stable chelating structure, and showed stronger selective adsorption.
34537654	1	51	theme	waste	226:230	arg1	material					239:246	waste cotton material	226:246	waste cotton material	226:246	In this work, a porous multi-functional biomass carbon was prepared by acid-base modification method, which realized the reuse of waste cotton material.
34537654	7	52	theme	XPS	1237:1239	arg1	results					1241:1247	XPS results	1237:1247	XPS results	1237:1247	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	4	53	theme	adsorption	648:657	arg1	capacity					659:666	high-efficiency adsorption capacity	632:666	high-efficiency adsorption capacity	632:666	These characteristics provide high-efficiency adsorption capacity for pollutants (1105.78 mg g-1 for Pb2+, 678.04 mg g-1 for Cu2+, and 590.72 mg g-1 for methylene blue (MB)), which is far superior to most reported adsorbents.
34537654	7	54	theme	surface	1264:1270	arg1	mechanisms					1327:1336	the main mechanisms	1318:1336	the main mechanisms of the adsorption reaction	1318:1363	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	7	54	theme	surface	1264:1270	arg1	complexation					1272:1283	surface complexation	1264:1283	surface complexation	1264:1283	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	7	54	theme	surface	1264:1270	arg1	attraction					1303:1312	electrostatic attraction	1289:1312	electrostatic attraction	1289:1312	XPS results confirmed that surface complexation and electrostatic attraction are the main mechanisms of the adsorption reaction.
34537654	1	55	theme	cotton	232:237	arg1	material					239:246	waste cotton material	226:246	waste cotton material	226:246	In this work, a porous multi-functional biomass carbon was prepared by acid-base modification method, which realized the reuse of waste cotton material.
33545825	1	0	from	coatings	179:186	arg1	polymer					196:202	PEEK polymer	191:202	PEEK polymer	191:202	In this paper, we propose a method of obtaining multi-component surface coatings on PEEK polymer, which is becoming increasingly interested in a very wide branch of medicine - orthopedics.
33545825	0	1	theme	PEEK	93:96	arg1	polymer					98:104	PEEK polymer	93:104	PEEK polymer	93:104	Characteristics of hybrid chitosan/phospholipid-sterol, peptide coatings on plasma activated PEEK polymer.
33545825	4	2	theme	angle	823:827	arg1	microscope					829:838	a Brewster angle microscope	812:838	a Brewster angle microscope	812:838	The physico-chemical properties of the ternary Langmuir films obtained on the water subphase were tested exploiting Langmuir trough and a Brewster angle microscope.
33545825	1	3	theme	multi-component	155:169	arg1	coatings					179:186	multi-component surface coatings	155:186	multi-component surface coatings on PEEK polymer, which is becoming increasingly interested in a very wide branch of medicine - orthopedics	155:293	In this paper, we propose a method of obtaining multi-component surface coatings on PEEK polymer, which is becoming increasingly interested in a very wide branch of medicine - orthopedics.
33545825	2	4	from	tissues	522:528	arg1	need					533:536	need	533:536	need	533:536	Thanks to the plasma techniques used and due to the presence of chitosan, the materials obtained are characterized by sterility, antisepticity, can accelerate wound healing, and serve as a drug delivery system directly to the tissues in need.
33545825	2	5	theme	delivery	490:497	arg1	system					499:504	a drug delivery system	483:504	a drug delivery system	483:504	Thanks to the plasma techniques used and due to the presence of chitosan, the materials obtained are characterized by sterility, antisepticity, can accelerate wound healing, and serve as a drug delivery system directly to the tissues in need.
33545825	2	5	theme	delivery	490:497	arg1	materials					374:382	the materials	370:382	the materials obtained	370:391	Thanks to the plasma techniques used and due to the presence of chitosan, the materials obtained are characterized by sterility, antisepticity, can accelerate wound healing, and serve as a drug delivery system directly to the tissues in need.
33545825	0	6	from	Characteristics	0:14	arg1	plasma					76:81	plasma	76:81	plasma	76:81	Characteristics of hybrid chitosan/phospholipid-sterol, peptide coatings on plasma activated PEEK polymer.
33545825	4	7	theme	Langmuir	723:730	arg1	films					732:736	the ternary Langmuir films	711:736	the ternary Langmuir films obtained on the water subphase	711:767	The physico-chemical properties of the ternary Langmuir films obtained on the water subphase were tested exploiting Langmuir trough and a Brewster angle microscope.
33545825	1	8	theme	wide	257:260	arg1	branch					262:267	a very wide branch	250:267	a very wide branch of medicine - orthopedics	250:293	In this paper, we propose a method of obtaining multi-component surface coatings on PEEK polymer, which is becoming increasingly interested in a very wide branch of medicine - orthopedics.
33545825	2	9	theme	drug	485:488	arg1	system					499:504	a drug delivery system	483:504	a drug delivery system	483:504	Thanks to the plasma techniques used and due to the presence of chitosan, the materials obtained are characterized by sterility, antisepticity, can accelerate wound healing, and serve as a drug delivery system directly to the tissues in need.
33545825	2	9	theme	drug	485:488	arg1	materials					374:382	the materials	370:382	the materials obtained	370:391	Thanks to the plasma techniques used and due to the presence of chitosan, the materials obtained are characterized by sterility, antisepticity, can accelerate wound healing, and serve as a drug delivery system directly to the tissues in need.
33545825	5	10	theme	hybrid	1037:1042	arg1	composition					1044:1054	the hybrid composition	1033:1054	the hybrid composition	1033:1054	Then they were transferred to the modified surfaces of the solid PEEK polymer, where changes in wettability as well as surface free energy were determined by the type of substrate/coating and the hybrid composition.
33545825	6	11	theme	ion	1135:1137	arg1	spectrometry					1144:1155	flight secondary ion mass spectrometry	1118:1155	flight secondary ion mass spectrometry	1118:1155	Additionally, surface chemistry was studied applying time of flight secondary ion mass spectrometry.
33545825	4	12	theme	ternary	715:721	arg1	films					732:736	the ternary Langmuir films	711:736	the ternary Langmuir films obtained on the water subphase	711:767	The physico-chemical properties of the ternary Langmuir films obtained on the water subphase were tested exploiting Langmuir trough and a Brewster angle microscope.
33545825	5	13	theme	solid	900:904	arg1	polymer					911:917	the solid PEEK polymer	896:917	the solid PEEK polymer	896:917	Then they were transferred to the modified surfaces of the solid PEEK polymer, where changes in wettability as well as surface free energy were determined by the type of substrate/coating and the hybrid composition.
33545825	6	14	theme	secondary	1125:1133	arg1	spectrometry					1144:1155	flight secondary ion mass spectrometry	1118:1155	flight secondary ion mass spectrometry	1118:1155	Additionally, surface chemistry was studied applying time of flight secondary ion mass spectrometry.
33545825	1	15	theme	surface	171:177	arg1	coatings					179:186	multi-component surface coatings	155:186	multi-component surface coatings on PEEK polymer, which is becoming increasingly interested in a very wide branch of medicine - orthopedics	155:293	In this paper, we propose a method of obtaining multi-component surface coatings on PEEK polymer, which is becoming increasingly interested in a very wide branch of medicine - orthopedics.
33545825	3	16	theme	surfaces	657:664	arg1	polarity					666:673	surfaces polarity	657:673	surfaces polarity	657:673	In addition, the use of ternary Langmuir-Blodgett (lipid-sterol, peptide) films has resulted in significant change of surfaces polarity.
33545825	0	17	theme	peptide	56:62	arg1	chitosan/phospholipid-sterol					26:53	hybrid chitosan/phospholipid-sterol	19:53	hybrid chitosan/phospholipid-sterol	19:53	Characteristics of hybrid chitosan/phospholipid-sterol, peptide coatings on plasma activated PEEK polymer.
33545825	0	17	theme	peptide	56:62	arg1	coatings					64:71	peptide coatings	56:71	peptide coatings	56:71	Characteristics of hybrid chitosan/phospholipid-sterol, peptide coatings on plasma activated PEEK polymer.
33545825	4	18	theme	films	732:736	arg1	properties					697:706	The physico-chemical properties	676:706	The physico-chemical properties of the ternary Langmuir films obtained on the water subphase	676:767	The physico-chemical properties of the ternary Langmuir films obtained on the water subphase were tested exploiting Langmuir trough and a Brewster angle microscope.
33545825	3	19	theme	polarity	666:673	arg1	change					647:652	significant change	635:652	significant change of surfaces polarity	635:673	In addition, the use of ternary Langmuir-Blodgett (lipid-sterol, peptide) films has resulted in significant change of surfaces polarity.
33545825	4	20	theme	Brewster	814:821	arg1	microscope					829:838	a Brewster angle microscope	812:838	a Brewster angle microscope	812:838	The physico-chemical properties of the ternary Langmuir films obtained on the water subphase were tested exploiting Langmuir trough and a Brewster angle microscope.
33545825	2	21	theme	chitosan	360:367	arg1	presence					348:355	the presence	344:355	the presence of chitosan	344:367	Thanks to the plasma techniques used and due to the presence of chitosan, the materials obtained are characterized by sterility, antisepticity, can accelerate wound healing, and serve as a drug delivery system directly to the tissues in need.
33545825	4	22	theme	physico-chemical	680:695	arg1	properties					697:706	The physico-chemical properties	676:706	The physico-chemical properties of the ternary Langmuir films obtained on the water subphase	676:767	The physico-chemical properties of the ternary Langmuir films obtained on the water subphase were tested exploiting Langmuir trough and a Brewster angle microscope.
33545825	5	23	from	energy	973:978	arg1	wettability					937:947	wettability	937:947	wettability	937:947	Then they were transferred to the modified surfaces of the solid PEEK polymer, where changes in wettability as well as surface free energy were determined by the type of substrate/coating and the hybrid composition.
33545825	1	24	theme	PEEK	191:194	arg1	polymer					196:202	PEEK polymer	191:202	PEEK polymer	191:202	In this paper, we propose a method of obtaining multi-component surface coatings on PEEK polymer, which is becoming increasingly interested in a very wide branch of medicine - orthopedics.
33545825	0	25	theme	chitosan/phospholipid-sterol	26:53	arg1	Characteristics					0:14	Characteristics	0:14	Characteristics of hybrid chitosan/phospholipid-sterol, peptide coatings on plasma	0:81	Characteristics of hybrid chitosan/phospholipid-sterol, peptide coatings on plasma activated PEEK polymer.
33545825	1	26	theme	medicine	272:279	arg1	branch					262:267	a very wide branch	250:267	a very wide branch of medicine - orthopedics	250:293	In this paper, we propose a method of obtaining multi-component surface coatings on PEEK polymer, which is becoming increasingly interested in a very wide branch of medicine - orthopedics.
33545825	5	27	theme	PEEK	906:909	arg1	polymer					911:917	the solid PEEK polymer	896:917	the solid PEEK polymer	896:917	Then they were transferred to the modified surfaces of the solid PEEK polymer, where changes in wettability as well as surface free energy were determined by the type of substrate/coating and the hybrid composition.
33545825	0	28	theme	hybrid	19:24	arg1	chitosan/phospholipid-sterol					26:53	hybrid chitosan/phospholipid-sterol	19:53	hybrid chitosan/phospholipid-sterol	19:53	Characteristics of hybrid chitosan/phospholipid-sterol, peptide coatings on plasma activated PEEK polymer.
33545825	0	28	theme	hybrid	19:24	arg1	coatings					64:71	peptide coatings	56:71	peptide coatings	56:71	Characteristics of hybrid chitosan/phospholipid-sterol, peptide coatings on plasma activated PEEK polymer.
33545825	1	29	from	branch	262:267	arg1	interested					236:245	interested	236:245	interested	236:245	In this paper, we propose a method of obtaining multi-component surface coatings on PEEK polymer, which is becoming increasingly interested in a very wide branch of medicine - orthopedics.
33545825	6	30	theme	mass	1139:1142	arg1	spectrometry					1144:1155	flight secondary ion mass spectrometry	1118:1155	flight secondary ion mass spectrometry	1118:1155	Additionally, surface chemistry was studied applying time of flight secondary ion mass spectrometry.
33545825	5	31	theme	polymer	911:917	arg1	surfaces					884:891	the modified surfaces	871:891	the modified surfaces of the solid PEEK polymer, where changes in wettability as well as surface free energy were determined by the type of substrate/coating and the hybrid composition	871:1054	Then they were transferred to the modified surfaces of the solid PEEK polymer, where changes in wettability as well as surface free energy were determined by the type of substrate/coating and the hybrid composition.
33545825	2	32	theme	wound	455:459	arg1	healing					461:467	wound healing	455:467	wound healing	455:467	Thanks to the plasma techniques used and due to the presence of chitosan, the materials obtained are characterized by sterility, antisepticity, can accelerate wound healing, and serve as a drug delivery system directly to the tissues in need.
33545825	1	33	theme	orthopedics	283:293	arg1	branch					262:267	a very wide branch	250:267	a very wide branch of medicine - orthopedics	250:293	In this paper, we propose a method of obtaining multi-component surface coatings on PEEK polymer, which is becoming increasingly interested in a very wide branch of medicine - orthopedics.
33545825	5	34	theme	substrate/coating	1011:1027	arg1	type					1003:1006	the type	999:1006	the type of substrate/coating	999:1027	Then they were transferred to the modified surfaces of the solid PEEK polymer, where changes in wettability as well as surface free energy were determined by the type of substrate/coating and the hybrid composition.
33545825	5	34	theme	substrate/coating	1011:1027	arg1	composition					1044:1054	the hybrid composition	1033:1054	the hybrid composition	1033:1054	Then they were transferred to the modified surfaces of the solid PEEK polymer, where changes in wettability as well as surface free energy were determined by the type of substrate/coating and the hybrid composition.
33545825	5	35	theme	surface	960:966	arg1	energy					973:978	surface free energy	960:978	changes in wettability as well as surface free energy	926:978	Then they were transferred to the modified surfaces of the solid PEEK polymer, where changes in wettability as well as surface free energy were determined by the type of substrate/coating and the hybrid composition.
33545825	5	36	theme	free	968:971	arg1	energy					973:978	surface free energy	960:978	changes in wettability as well as surface free energy	926:978	Then they were transferred to the modified surfaces of the solid PEEK polymer, where changes in wettability as well as surface free energy were determined by the type of substrate/coating and the hybrid composition.
33545825	3	37	dep	Langmuir-Blodgett	571:587	arg1	peptide					604:610	peptide	604:610	peptide	604:610	In addition, the use of ternary Langmuir-Blodgett (lipid-sterol, peptide) films has resulted in significant change of surfaces polarity.
33545825	3	37	dep	Langmuir-Blodgett	571:587	arg1	lipid-sterol					590:601	lipid-sterol	590:601	lipid-sterol	590:601	In addition, the use of ternary Langmuir-Blodgett (lipid-sterol, peptide) films has resulted in significant change of surfaces polarity.
33545825	1	38	from	interested	236:245	arg1	branch					262:267	a very wide branch	250:267	a very wide branch of medicine - orthopedics	250:293	In this paper, we propose a method of obtaining multi-component surface coatings on PEEK polymer, which is becoming increasingly interested in a very wide branch of medicine - orthopedics.
33545825	4	39	theme	Langmuir	792:799	arg1	trough					801:806	Langmuir trough	792:806	Langmuir trough	792:806	The physico-chemical properties of the ternary Langmuir films obtained on the water subphase were tested exploiting Langmuir trough and a Brewster angle microscope.
33545825	3	40	theme	significant	635:645	arg1	change					647:652	significant change	635:652	significant change of surfaces polarity	635:673	In addition, the use of ternary Langmuir-Blodgett (lipid-sterol, peptide) films has resulted in significant change of surfaces polarity.
33545825	5	41	theme	modified	875:882	arg1	surfaces					884:891	the modified surfaces	871:891	the modified surfaces of the solid PEEK polymer, where changes in wettability as well as surface free energy were determined by the type of substrate/coating and the hybrid composition	871:1054	Then they were transferred to the modified surfaces of the solid PEEK polymer, where changes in wettability as well as surface free energy were determined by the type of substrate/coating and the hybrid composition.
33545825	6	42	theme	spectrometry	1144:1155	arg1	time					1110:1113	time	1110:1113	time of flight secondary ion mass spectrometry	1110:1155	Additionally, surface chemistry was studied applying time of flight secondary ion mass spectrometry.
33545825	3	43	theme	ternary	563:569	arg1	Langmuir-Blodgett					571:587	ternary Langmuir-Blodgett	563:587	ternary Langmuir-Blodgett (lipid-sterol, peptide) films	563:617	In addition, the use of ternary Langmuir-Blodgett (lipid-sterol, peptide) films has resulted in significant change of surfaces polarity.
33545825	6	44	theme	surface	1071:1077	arg1	chemistry					1079:1087	surface chemistry	1071:1087	surface chemistry	1071:1087	Additionally, surface chemistry was studied applying time of flight secondary ion mass spectrometry.
33545825	6	45	theme	flight	1118:1123	arg1	spectrometry					1144:1155	flight secondary ion mass spectrometry	1118:1155	flight secondary ion mass spectrometry	1118:1155	Additionally, surface chemistry was studied applying time of flight secondary ion mass spectrometry.
33545825	3	46	theme	Langmuir-Blodgett	571:587	arg1	films					613:617	ternary Langmuir-Blodgett (lipid-sterol, peptide) films	563:617	ternary Langmuir-Blodgett (lipid-sterol, peptide) films	563:617	In addition, the use of ternary Langmuir-Blodgett (lipid-sterol, peptide) films has resulted in significant change of surfaces polarity.
33545825	2	47	theme	plasma	310:315	arg1	techniques					317:326	the plasma techniques	306:326	the plasma techniques used and due to the presence of chitosan	306:367	Thanks to the plasma techniques used and due to the presence of chitosan, the materials obtained are characterized by sterility, antisepticity, can accelerate wound healing, and serve as a drug delivery system directly to the tissues in need.
33545825	3	48	theme	films	613:617	arg1	use					556:558	the use	552:558	the use of ternary Langmuir-Blodgett (lipid-sterol, peptide) films	552:617	In addition, the use of ternary Langmuir-Blodgett (lipid-sterol, peptide) films has resulted in significant change of surfaces polarity.
33545825	4	49	theme	water	754:758	arg1	subphase					760:767	the water subphase	750:767	the water subphase	750:767	The physico-chemical properties of the ternary Langmuir films obtained on the water subphase were tested exploiting Langmuir trough and a Brewster angle microscope.
33545825	5	50	from	changes	926:932	arg1	wettability					937:947	wettability	937:947	wettability	937:947	Then they were transferred to the modified surfaces of the solid PEEK polymer, where changes in wettability as well as surface free energy were determined by the type of substrate/coating and the hybrid composition.
32272315	0	0	theme	alginate-hydroxyapatite	102:124	arg1	nanoparticles					126:138	sodium alginate-hydroxyapatite nanoparticles	95:138	sodium alginate-hydroxyapatite nanoparticles	95:138	Development and characterisation of bilayered periosteum-inspired composite membranes based on sodium alginate-hydroxyapatite nanoparticles.
32272315	10	1	theme	regeneration	1600:1611	arg1	applications					1613:1624	guided tissue regeneration applications	1586:1624	guided tissue regeneration applications	1586:1624	These periosteum-inspired membranes are promising biomaterials for guided tissue regeneration applications.
32272315	9	2	theme	fibroblasts-like	1450:1465	arg1	cells					1467:1471	fibroblasts-like cells	1450:1471	fibroblasts-like cells	1450:1471	Finally, it was proved that osteoblast-like cells proliferated and differentiated on the mineral-rich side, specially when a higher amount of nanohydroxyapatite was used, whereas fibroblasts-like cells were able to proliferate on the fibrous side.
32272315	0	3	theme	sodium	95:100	arg1	nanoparticles					126:138	sodium alginate-hydroxyapatite nanoparticles	95:138	sodium alginate-hydroxyapatite nanoparticles	95:138	Development and characterisation of bilayered periosteum-inspired composite membranes based on sodium alginate-hydroxyapatite nanoparticles.
32272315	9	4	theme	nanohydroxyapatite	1413:1430	arg1	nanohydroxyapatite					1413:1430	nanohydroxyapatite	1413:1430	nanohydroxyapatite	1413:1430	Finally, it was proved that osteoblast-like cells proliferated and differentiated on the mineral-rich side, specially when a higher amount of nanohydroxyapatite was used, whereas fibroblasts-like cells were able to proliferate on the fibrous side.
32272315	9	4	theme	nanohydroxyapatite	1413:1430	arg1	amount					1403:1408	a higher amount	1394:1408	a higher amount of nanohydroxyapatite	1394:1430	Finally, it was proved that osteoblast-like cells proliferated and differentiated on the mineral-rich side, specially when a higher amount of nanohydroxyapatite was used, whereas fibroblasts-like cells were able to proliferate on the fibrous side.
32272315	8	5	theme	amount	1147:1152	arg1	effect					1137:1142	the effect	1133:1142	the effect of amount of nanohydroxyapatite	1133:1174	Moreover, the effect of amount of nanohydroxyapatite was reflected in a decrease of the membranes' plasticity and an increment of degradation rate.
32272315	10	6	theme	periosteum-inspired	1525:1543	arg1	membranes					1545:1553	These periosteum-inspired membranes	1519:1553	These periosteum-inspired membranes	1519:1553	These periosteum-inspired membranes are promising biomaterials for guided tissue regeneration applications.
32272315	10	6	theme	periosteum-inspired	1525:1543	arg1	biomaterials					1569:1580	promising biomaterials	1559:1580	promising biomaterials for guided tissue regeneration applications	1559:1624	These periosteum-inspired membranes are promising biomaterials for guided tissue regeneration applications.
32272315	9	7	used	used	1436:1439	arg2	amount					1403:1408	a higher amount	1394:1408	a higher amount of nanohydroxyapatite	1394:1430	Finally, it was proved that osteoblast-like cells proliferated and differentiated on the mineral-rich side, specially when a higher amount of nanohydroxyapatite was used, whereas fibroblasts-like cells were able to proliferate on the fibrous side.
32272315	9	7	used	used	1436:1439	arg2	nanohydroxyapatite					1413:1430	nanohydroxyapatite	1413:1430	nanohydroxyapatite	1413:1430	Finally, it was proved that osteoblast-like cells proliferated and differentiated on the mineral-rich side, specially when a higher amount of nanohydroxyapatite was used, whereas fibroblasts-like cells were able to proliferate on the fibrous side.
32272315	10	8	theme	guided	1586:1591	arg1	applications					1613:1624	guided tissue regeneration applications	1586:1624	guided tissue regeneration applications	1586:1624	These periosteum-inspired membranes are promising biomaterials for guided tissue regeneration applications.
32272315	7	9	dep	porous	1037:1042	arg1	fibrous					1044:1050	fibrous	1044:1050	fibrous	1044:1050	Distinct surface characteristics were achieved on each side of the membranes, resulting in a highly porous fibrous side and a mineral-rich side with higher roughness and lower porosity.
32272315	6	10	dep	strength	891:898	arg1	the					887:889	the	887:889	the	887:889	FINDINGS The ionic bonding between alginate polysaccharide networks and nanohydroxyapatite was proven, and had a clear effect in the strength and microstructure of the hydrogels.
32272315	1	11	contain	have	206:209	arg2	composition					249:259	a chemical composition	238:259	a chemical composition	238:259	BACKGROUND AND AIM Membranes for guided bone regeneration should have a mechanical structure and a chemical composition suitable for mimicking biological structures.
32272315	1	11	contain	have	206:209	arg1	Membranes					160:168	BACKGROUND AND AIM Membranes	141:168	BACKGROUND AND AIM Membranes for guided bone regeneration	141:197	BACKGROUND AND AIM Membranes for guided bone regeneration should have a mechanical structure and a chemical composition suitable for mimicking biological structures.
32272315	1	11	contain	have	206:209	arg2	structure					224:232	mechanical structure	213:232	mechanical structure	213:232	BACKGROUND AND AIM Membranes for guided bone regeneration should have a mechanical structure and a chemical composition suitable for mimicking biological structures.
32272315	8	12	theme	nanohydroxyapatite	1157:1174	arg1	nanohydroxyapatite					1157:1174	nanohydroxyapatite	1157:1174	nanohydroxyapatite	1157:1174	Moreover, the effect of amount of nanohydroxyapatite was reflected in a decrease of the membranes' plasticity and an increment of degradation rate.
32272315	8	12	theme	nanohydroxyapatite	1157:1174	arg1	amount					1147:1152	amount	1147:1152	amount of nanohydroxyapatite	1147:1174	Moreover, the effect of amount of nanohydroxyapatite was reflected in a decrease of the membranes' plasticity and an increment of degradation rate.
32272315	9	13	theme	osteoblast-like	1299:1313	arg1	cells					1315:1319	osteoblast-like cells	1299:1319	osteoblast-like cells	1299:1319	Finally, it was proved that osteoblast-like cells proliferated and differentiated on the mineral-rich side, specially when a higher amount of nanohydroxyapatite was used, whereas fibroblasts-like cells were able to proliferate on the fibrous side.
32272315	1	14	theme	guided	174:179	arg1	regeneration					186:197	guided bone regeneration	174:197	guided bone regeneration	174:197	BACKGROUND AND AIM Membranes for guided bone regeneration should have a mechanical structure and a chemical composition suitable for mimicking biological structures.
32272315	5	15	theme	membranes	747:755	arg1	side					735:738	each side	730:738	each side of the membranes	730:755	Finally, cell cultures were performed on each side of the membranes.
32272315	7	16	theme	higher	1086:1091	arg1	roughness					1093:1101	higher roughness	1086:1101	higher roughness	1086:1101	Distinct surface characteristics were achieved on each side of the membranes, resulting in a highly porous fibrous side and a mineral-rich side with higher roughness and lower porosity.
32272315	7	17	theme	membranes	1004:1012	arg1	side					992:995	each side	987:995	each side of the membranes	987:1012	Distinct surface characteristics were achieved on each side of the membranes, resulting in a highly porous fibrous side and a mineral-rich side with higher roughness and lower porosity.
32272315	6	18	theme	hydrogels	926:934	arg1	microstructure					904:917	microstructure	904:917	microstructure	904:917	FINDINGS The ionic bonding between alginate polysaccharide networks and nanohydroxyapatite was proven, and had a clear effect in the strength and microstructure of the hydrogels.
32272315	6	18	theme	hydrogels	926:934	arg1	strength					891:898	strength	891:898	strength	891:898	FINDINGS The ionic bonding between alginate polysaccharide networks and nanohydroxyapatite was proven, and had a clear effect in the strength and microstructure of the hydrogels.
32272315	1	19	theme	mechanical	213:222	arg1	structure					224:232	mechanical structure	213:232	mechanical structure	213:232	BACKGROUND AND AIM Membranes for guided bone regeneration should have a mechanical structure and a chemical composition suitable for mimicking biological structures.
32272315	7	20	with	side	1052:1055	arg1	roughness					1093:1101	higher roughness	1086:1101	higher roughness	1086:1101	Distinct surface characteristics were achieved on each side of the membranes, resulting in a highly porous fibrous side and a mineral-rich side with higher roughness and lower porosity.
32272315	7	20	with	side	1052:1055	arg1	porosity					1113:1120	lower porosity	1107:1120	lower porosity	1107:1120	Distinct surface characteristics were achieved on each side of the membranes, resulting in a highly porous fibrous side and a mineral-rich side with higher roughness and lower porosity.
32272315	10	21	theme	promising	1559:1567	arg1	membranes					1545:1553	These periosteum-inspired membranes	1519:1553	These periosteum-inspired membranes	1519:1553	These periosteum-inspired membranes are promising biomaterials for guided tissue regeneration applications.
32272315	10	21	theme	promising	1559:1567	arg1	biomaterials					1569:1580	promising biomaterials	1559:1580	promising biomaterials for guided tissue regeneration applications	1559:1624	These periosteum-inspired membranes are promising biomaterials for guided tissue regeneration applications.
32272315	2	22	theme	bilayered	370:378	arg1	membranes					380:388	periosteum-inspired bilayered membranes	350:388	periosteum-inspired bilayered membranes obtained by crosslinking alginate with different amounts of nanohydroxyapatite	350:467	In this work, we pursue the development of periosteum-inspired bilayered membranes obtained by crosslinking alginate with different amounts of nanohydroxyapatite.
32272315	2	23	theme	nanohydroxyapatite	450:467	arg1	nanohydroxyapatite					450:467	nanohydroxyapatite	450:467	nanohydroxyapatite	450:467	In this work, we pursue the development of periosteum-inspired bilayered membranes obtained by crosslinking alginate with different amounts of nanohydroxyapatite.
32272315	2	23	theme	nanohydroxyapatite	450:467	arg1	amounts					439:445	different amounts	429:445	different amounts of nanohydroxyapatite	429:467	In this work, we pursue the development of periosteum-inspired bilayered membranes obtained by crosslinking alginate with different amounts of nanohydroxyapatite.
32272315	3	24	theme	EXPERIMENTS	470:480	arg1	interaction					510:520	EXPERIMENTS Alginate-nanohydroxyapatite interaction	470:520	EXPERIMENTS Alginate-nanohydroxyapatite interaction	470:520	EXPERIMENTS Alginate-nanohydroxyapatite interaction was studied by rheology and infrared spectroscopy measurements.
32272315	7	25	theme	surface	946:952	arg1	characteristics					954:968	Distinct surface characteristics	937:968	Distinct surface characteristics	937:968	Distinct surface characteristics were achieved on each side of the membranes, resulting in a highly porous fibrous side and a mineral-rich side with higher roughness and lower porosity.
32272315	2	26	theme	periosteum-inspired	350:368	arg1	membranes					380:388	periosteum-inspired bilayered membranes	350:388	periosteum-inspired bilayered membranes obtained by crosslinking alginate with different amounts of nanohydroxyapatite	350:467	In this work, we pursue the development of periosteum-inspired bilayered membranes obtained by crosslinking alginate with different amounts of nanohydroxyapatite.
32272315	10	27	theme	tissue	1593:1598	arg1	applications					1613:1624	guided tissue regeneration applications	1586:1624	guided tissue regeneration applications	1586:1624	These periosteum-inspired membranes are promising biomaterials for guided tissue regeneration applications.
32272315	1	28	theme	BACKGROUND	141:150	arg1	Membranes					160:168	BACKGROUND AND AIM Membranes	141:168	BACKGROUND AND AIM Membranes for guided bone regeneration	141:197	BACKGROUND AND AIM Membranes for guided bone regeneration should have a mechanical structure and a chemical composition suitable for mimicking biological structures.
32272315	9	29	theme	fibrous	1505:1511	arg1	side					1513:1516	the fibrous side	1501:1516	the fibrous side	1501:1516	Finally, it was proved that osteoblast-like cells proliferated and differentiated on the mineral-rich side, specially when a higher amount of nanohydroxyapatite was used, whereas fibroblasts-like cells were able to proliferate on the fibrous side.
32272315	7	30	with	side	1076:1079	arg1	roughness					1093:1101	higher roughness	1086:1101	higher roughness	1086:1101	Distinct surface characteristics were achieved on each side of the membranes, resulting in a highly porous fibrous side and a mineral-rich side with higher roughness and lower porosity.
32272315	7	30	with	side	1076:1079	arg1	porosity					1113:1120	lower porosity	1107:1120	lower porosity	1107:1120	Distinct surface characteristics were achieved on each side of the membranes, resulting in a highly porous fibrous side and a mineral-rich side with higher roughness and lower porosity.
32272315	1	31	theme	chemical	240:247	arg1	composition					249:259	a chemical composition	238:259	a chemical composition	238:259	BACKGROUND AND AIM Membranes for guided bone regeneration should have a mechanical structure and a chemical composition suitable for mimicking biological structures.
32272315	0	32	theme	periosteum-inspired	46:64	arg1	membranes					76:84	bilayered periosteum-inspired composite membranes	36:84	bilayered periosteum-inspired composite membranes	36:84	Development and characterisation of bilayered periosteum-inspired composite membranes based on sodium alginate-hydroxyapatite nanoparticles.
32272315	7	33	theme	Distinct	937:944	arg1	characteristics					954:968	Distinct surface characteristics	937:968	Distinct surface characteristics	937:968	Distinct surface characteristics were achieved on each side of the membranes, resulting in a highly porous fibrous side and a mineral-rich side with higher roughness and lower porosity.
32272315	9	34	theme	mineral-rich	1360:1371	arg1	side					1373:1376	the mineral-rich side	1356:1376	the mineral-rich side	1356:1376	Finally, it was proved that osteoblast-like cells proliferated and differentiated on the mineral-rich side, specially when a higher amount of nanohydroxyapatite was used, whereas fibroblasts-like cells were able to proliferate on the fibrous side.
32272315	1	35	dep	structure	224:232	arg1	a					211:211	a	211:211	a	211:211	BACKGROUND AND AIM Membranes for guided bone regeneration should have a mechanical structure and a chemical composition suitable for mimicking biological structures.
32272315	6	36	theme	polysaccharide	802:815	arg1	networks					817:824	alginate polysaccharide networks	793:824	alginate polysaccharide networks	793:824	FINDINGS The ionic bonding between alginate polysaccharide networks and nanohydroxyapatite was proven, and had a clear effect in the strength and microstructure of the hydrogels.
32272315	3	37	theme	spectroscopy	559:570	arg1	measurements					572:583	infrared spectroscopy measurements	550:583	infrared spectroscopy measurements	550:583	EXPERIMENTS Alginate-nanohydroxyapatite interaction was studied by rheology and infrared spectroscopy measurements.
32272315	0	38	theme	bilayered	36:44	arg1	membranes					76:84	bilayered periosteum-inspired composite membranes	36:84	bilayered periosteum-inspired composite membranes	36:84	Development and characterisation of bilayered periosteum-inspired composite membranes based on sodium alginate-hydroxyapatite nanoparticles.
32272315	7	39	theme	porous	1037:1042	arg1	side					1052:1055	a highly porous fibrous side	1028:1055	a highly porous fibrous side	1028:1055	Distinct surface characteristics were achieved on each side of the membranes, resulting in a highly porous fibrous side and a mineral-rich side with higher roughness and lower porosity.
32272315	8	40	theme	rate	1265:1268	arg1	increment					1240:1248	an increment	1237:1248	an increment of degradation rate	1237:1268	Moreover, the effect of amount of nanohydroxyapatite was reflected in a decrease of the membranes' plasticity and an increment of degradation rate.
32272315	8	40	theme	rate	1265:1268	arg1	decrease					1195:1202	a decrease	1193:1202	a decrease of the membranes' plasticity	1193:1231	Moreover, the effect of amount of nanohydroxyapatite was reflected in a decrease of the membranes' plasticity and an increment of degradation rate.
32272315	1	41	theme	suitable	261:268	arg1	structure					224:232	mechanical structure	213:232	mechanical structure	213:232	BACKGROUND AND AIM Membranes for guided bone regeneration should have a mechanical structure and a chemical composition suitable for mimicking biological structures.
32272315	0	42	theme	membranes	76:84	arg1	characterisation					16:31	characterisation	16:31	characterisation	16:31	Development and characterisation of bilayered periosteum-inspired composite membranes based on sodium alginate-hydroxyapatite nanoparticles.
32272315	0	42	theme	membranes	76:84	arg1	Development					0:10	Development	0:10	Development	0:10	Development and characterisation of bilayered periosteum-inspired composite membranes based on sodium alginate-hydroxyapatite nanoparticles.
32272315	1	43	theme	AIM	156:158	arg1	Membranes					160:168	BACKGROUND AND AIM Membranes	141:168	BACKGROUND AND AIM Membranes for guided bone regeneration	141:197	BACKGROUND AND AIM Membranes for guided bone regeneration should have a mechanical structure and a chemical composition suitable for mimicking biological structures.
32272315	0	44	theme	composite	66:74	arg1	membranes					76:84	bilayered periosteum-inspired composite membranes	36:84	bilayered periosteum-inspired composite membranes	36:84	Development and characterisation of bilayered periosteum-inspired composite membranes based on sodium alginate-hydroxyapatite nanoparticles.
32272315	8	45	theme	plasticity	1222:1231	arg1	increment					1240:1248	an increment	1237:1248	an increment of degradation rate	1237:1268	Moreover, the effect of amount of nanohydroxyapatite was reflected in a decrease of the membranes' plasticity and an increment of degradation rate.
32272315	8	45	theme	plasticity	1222:1231	arg1	decrease					1195:1202	a decrease	1193:1202	a decrease of the membranes' plasticity	1193:1231	Moreover, the effect of amount of nanohydroxyapatite was reflected in a decrease of the membranes' plasticity and an increment of degradation rate.
32272315	6	46	theme	alginate	793:800	arg1	networks					817:824	alginate polysaccharide networks	793:824	alginate polysaccharide networks	793:824	FINDINGS The ionic bonding between alginate polysaccharide networks and nanohydroxyapatite was proven, and had a clear effect in the strength and microstructure of the hydrogels.
32272315	4	47	theme	surface	669:675	arg1	morphology					677:686	surface morphology	669:686	surface morphology	669:686	The membranes were characterized regarding their tensile strength, degradation and surface morphology.
32272315	7	48	theme	mineral-rich	1063:1074	arg1	side					1076:1079	a mineral-rich side	1061:1079	a mineral-rich side with higher roughness and lower porosity	1061:1120	Distinct surface characteristics were achieved on each side of the membranes, resulting in a highly porous fibrous side and a mineral-rich side with higher roughness and lower porosity.
32272315	5	49	theme	cell	698:701	arg1	cultures					703:710	cell cultures	698:710	cell cultures	698:710	Finally, cell cultures were performed on each side of the membranes.
32272315	2	50	theme	membranes	380:388	arg1	development					335:345	the development	331:345	the development of periosteum-inspired bilayered membranes obtained by crosslinking alginate with different amounts of nanohydroxyapatite	331:467	In this work, we pursue the development of periosteum-inspired bilayered membranes obtained by crosslinking alginate with different amounts of nanohydroxyapatite.
32272315	8	51	theme	degradation	1253:1263	arg1	rate					1265:1268	degradation rate	1253:1268	degradation rate	1253:1268	Moreover, the effect of amount of nanohydroxyapatite was reflected in a decrease of the membranes' plasticity and an increment of degradation rate.
32272315	9	52	theme	higher	1396:1401	arg1	nanohydroxyapatite					1413:1430	nanohydroxyapatite	1413:1430	nanohydroxyapatite	1413:1430	Finally, it was proved that osteoblast-like cells proliferated and differentiated on the mineral-rich side, specially when a higher amount of nanohydroxyapatite was used, whereas fibroblasts-like cells were able to proliferate on the fibrous side.
32272315	9	52	theme	higher	1396:1401	arg1	amount					1403:1408	a higher amount	1394:1408	a higher amount of nanohydroxyapatite	1394:1430	Finally, it was proved that osteoblast-like cells proliferated and differentiated on the mineral-rich side, specially when a higher amount of nanohydroxyapatite was used, whereas fibroblasts-like cells were able to proliferate on the fibrous side.
32272315	6	53	theme	clear	871:875	arg1	effect					877:882	a clear effect	869:882	a clear effect	869:882	FINDINGS The ionic bonding between alginate polysaccharide networks and nanohydroxyapatite was proven, and had a clear effect in the strength and microstructure of the hydrogels.
32272315	1	54	theme	bone	181:184	arg1	regeneration					186:197	guided bone regeneration	174:197	guided bone regeneration	174:197	BACKGROUND AND AIM Membranes for guided bone regeneration should have a mechanical structure and a chemical composition suitable for mimicking biological structures.
32272315	3	55	theme	infrared	550:557	arg1	measurements					572:583	infrared spectroscopy measurements	550:583	infrared spectroscopy measurements	550:583	EXPERIMENTS Alginate-nanohydroxyapatite interaction was studied by rheology and infrared spectroscopy measurements.
32272315	1	56	theme	biological	284:293	arg1	structures					295:304	biological structures	284:304	biological structures	284:304	BACKGROUND AND AIM Membranes for guided bone regeneration should have a mechanical structure and a chemical composition suitable for mimicking biological structures.
32272315	3	57	theme	Alginate-nanohydroxyapatite	482:508	arg1	interaction					510:520	EXPERIMENTS Alginate-nanohydroxyapatite interaction	470:520	EXPERIMENTS Alginate-nanohydroxyapatite interaction	470:520	EXPERIMENTS Alginate-nanohydroxyapatite interaction was studied by rheology and infrared spectroscopy measurements.
32272315	4	58	theme	tensile	635:641	arg1	strength					643:650	their tensile strength	629:650	their tensile strength	629:650	The membranes were characterized regarding their tensile strength, degradation and surface morphology.
32272315	6	59	theme	ionic	771:775	arg1	bonding					777:783	The ionic bonding	767:783	The ionic bonding between alginate polysaccharide networks	767:824	FINDINGS The ionic bonding between alginate polysaccharide networks and nanohydroxyapatite was proven, and had a clear effect in the strength and microstructure of the hydrogels.
32272315	7	60	theme	lower	1107:1111	arg1	porosity					1113:1120	lower porosity	1107:1120	lower porosity	1107:1120	Distinct surface characteristics were achieved on each side of the membranes, resulting in a highly porous fibrous side and a mineral-rich side with higher roughness and lower porosity.
32272315	2	61	theme	different	429:437	arg1	nanohydroxyapatite					450:467	nanohydroxyapatite	450:467	nanohydroxyapatite	450:467	In this work, we pursue the development of periosteum-inspired bilayered membranes obtained by crosslinking alginate with different amounts of nanohydroxyapatite.
32272315	2	61	theme	different	429:437	arg1	amounts					439:445	different amounts	429:445	different amounts of nanohydroxyapatite	429:467	In this work, we pursue the development of periosteum-inspired bilayered membranes obtained by crosslinking alginate with different amounts of nanohydroxyapatite.
33034858	10	0	theme	water	1468:1472	arg1	filtration					1441:1450	filtration	1441:1450	filtration of contaminated water and air purification	1441:1493	Hence, the developed simple and sustainable process could be highly suitable for filtration of contaminated water and air purification.
33034858	1	1	theme	Environmental	152:164	arg1	process					183:189	Environmental benign catalytic process	152:189	Environmental benign catalytic process	152:189	Environmental benign catalytic process was developed for the valorisation of sugarcane bagasse into functional nanomaterials.
33034858	6	2	theme	lignin	893:898	arg1	nanomaterials					900:912	Obtained silica and lignin nanomaterials	873:912	Obtained silica and lignin nanomaterials	873:912	Obtained silica and lignin nanomaterials were used in the fabrication of strong as well as flexible functional membrane for purification of solute particles and gases.
33034858	10	3	theme	contaminated	1455:1466	arg1	water					1468:1472	contaminated water	1455:1472	contaminated water	1455:1472	Hence, the developed simple and sustainable process could be highly suitable for filtration of contaminated water and air purification.
33034858	3	4	theme	%	609:609	arg1	yield					611:615	10.15% yield	604:615	10.15% yield	604:615	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	10	5	theme	simple	1381:1386	arg1	process					1404:1410	the developed simple and sustainable process	1367:1410	the developed simple and sustainable process	1367:1410	Hence, the developed simple and sustainable process could be highly suitable for filtration of contaminated water and air purification.
33034858	10	5	theme	simple	1381:1386	arg1	suitable					1428:1435	suitable	1428:1435	suitable	1428:1435	Hence, the developed simple and sustainable process could be highly suitable for filtration of contaminated water and air purification.
33034858	1	6	theme	benign	166:171	arg1	process					183:189	Environmental benign catalytic process	152:189	Environmental benign catalytic process	152:189	Environmental benign catalytic process was developed for the valorisation of sugarcane bagasse into functional nanomaterials.
33034858	10	7	theme	purification	1482:1493	arg1	filtration					1441:1450	filtration	1441:1450	filtration of contaminated water and air purification	1441:1493	Hence, the developed simple and sustainable process could be highly suitable for filtration of contaminated water and air purification.
33034858	3	8	theme	peroxide	456:463	arg1	combination					441:451	a combination	439:451	a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt)	439:510	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	2	9	with	pre-treatment	386:398	arg1	ethanol					416:422	ethanol	416:422	ethanol	416:422	Bagasse saccharification was carried out with an acid catalyst (H2SO4 0.5%, wt/wt) to separate sugars after pre-treatment of biomass with ethanol.
33034858	6	10	theme	gases	1034:1038	arg1	purification					997:1008	purification	997:1008	purification of solute particles and gases	997:1038	Obtained silica and lignin nanomaterials were used in the fabrication of strong as well as flexible functional membrane for purification of solute particles and gases.
33034858	6	11	theme	silica	882:887	arg1	nanomaterials					900:912	Obtained silica and lignin nanomaterials	873:912	Obtained silica and lignin nanomaterials	873:912	Obtained silica and lignin nanomaterials were used in the fabrication of strong as well as flexible functional membrane for purification of solute particles and gases.
33034858	7	12	theme	type	1117:1120	arg1	isotherm					1125:1132	type II isotherm	1117:1132	type II isotherm	1117:1132	The adsorption/desorption curve of the developed functional membrane showed type II isotherm with a H3 hysteresis loop.
33034858	7	13	theme	hysteresis	1144:1153	arg1	loop					1155:1158	a H3 hysteresis loop	1139:1158	a H3 hysteresis loop	1139:1158	The adsorption/desorption curve of the developed functional membrane showed type II isotherm with a H3 hysteresis loop.
33034858	5	14	theme	synthesised	790:800	arg1	materials					802:810	the synthesised materials	786:810	the synthesised materials	786:810	Zeta potential (ζ) of the synthesised materials was found to be - 35.6 mV for SiO2 and - 13.1 mV for lignin.
33034858	3	15	theme	0.5	475:477	arg1	%					478:478	%	478:478	%	478:478	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	7	16	theme	functional	1090:1099	arg1	membrane					1101:1108	the developed functional membrane	1076:1108	the developed functional membrane	1076:1108	The adsorption/desorption curve of the developed functional membrane showed type II isotherm with a H3 hysteresis loop.
33034858	10	17	theme	sustainable	1392:1402	arg1	process					1404:1410	the developed simple and sustainable process	1367:1410	the developed simple and sustainable process	1367:1410	Hence, the developed simple and sustainable process could be highly suitable for filtration of contaminated water and air purification.
33034858	10	17	theme	sustainable	1392:1402	arg1	suitable					1428:1435	suitable	1428:1435	suitable	1428:1435	Hence, the developed simple and sustainable process could be highly suitable for filtration of contaminated water and air purification.
33034858	6	18	theme	membrane	984:991	arg1	fabrication					931:941	the fabrication	927:941	the fabrication of strong as well as flexible functional membrane	927:991	Obtained silica and lignin nanomaterials were used in the fabrication of strong as well as flexible functional membrane for purification of solute particles and gases.
33034858	3	19	theme	%	497:497	arg1	wt/wt					505:509	wt/wt	505:509	wt/wt	505:509	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	3	19	theme	%	497:497	arg1	NaOH					499:502	1% NaOH	496:502	1% NaOH	496:502	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	3	19	theme	%	497:497	arg1	H2O2					480:483	0.5% H2O2	475:483	0.5% H2O2	475:483	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	3	20	with	20 nm	593:597	arg1	yield					611:615	10.15% yield	604:615	10.15% yield	604:615	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	1	21	theme	catalytic	173:181	arg1	process					183:189	Environmental benign catalytic process	152:189	Environmental benign catalytic process	152:189	Environmental benign catalytic process was developed for the valorisation of sugarcane bagasse into functional nanomaterials.
33034858	6	22	theme	Obtained	873:880	arg1	nanomaterials					900:912	Obtained silica and lignin nanomaterials	873:912	Obtained silica and lignin nanomaterials	873:912	Obtained silica and lignin nanomaterials were used in the fabrication of strong as well as flexible functional membrane for purification of solute particles and gases.
33034858	3	23	theme	bagasse	623:629	arg1	slurry					631:636	bagasse slurry	623:636	bagasse slurry	623:636	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	4	24	theme	powdered	749:756	arg1	form					758:761	powdered form	749:761	powdered form	749:761	In the final step, precipitation using catalyst was completed to separate highly pure functional materials in powdered form.
33034858	6	25	theme	functional	973:982	arg1	membrane					984:991	strong as well as flexible functional membrane	946:991	strong as well as flexible functional membrane	946:991	Obtained silica and lignin nanomaterials were used in the fabrication of strong as well as flexible functional membrane for purification of solute particles and gases.
33034858	10	26	theme	air	1478:1480	arg1	purification					1482:1493	air purification	1478:1493	air purification	1478:1493	Hence, the developed simple and sustainable process could be highly suitable for filtration of contaminated water and air purification.
33034858	9	27	theme	pore	1260:1263	arg1	volume					1265:1270	pore volume	1260:1270	pore volume	1260:1270	The pore size and pore volume as recorded by Barrett-Joyner-Halenda method was 25.5 nm and 0.624 cm3/g, respectively.
33034858	6	28	used	used	919:922	arg2	nanomaterials					900:912	Obtained silica and lignin nanomaterials	873:912	Obtained silica and lignin nanomaterials	873:912	Obtained silica and lignin nanomaterials were used in the fabrication of strong as well as flexible functional membrane for purification of solute particles and gases.
33034858	9	29	theme	pore	1246:1249	arg1	25.5 nm					1321:1327	25.5 nm	1321:1327	25.5 nm	1321:1327	The pore size and pore volume as recorded by Barrett-Joyner-Halenda method was 25.5 nm and 0.624 cm3/g, respectively.
33034858	9	29	theme	pore	1246:1249	arg1	size					1251:1254	pore size	1246:1254	pore size	1246:1254	The pore size and pore volume as recorded by Barrett-Joyner-Halenda method was 25.5 nm and 0.624 cm3/g, respectively.
33034858	4	30	theme	final	646:650	arg1	step					652:655	the final step	642:655	the final step	642:655	In the final step, precipitation using catalyst was completed to separate highly pure functional materials in powdered form.
33034858	3	31	dep	SiO2	551:554	arg1	35 nm					557:561	35 nm	557:561	35 nm	557:561	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	7	32	theme	developed	1080:1088	arg1	membrane					1101:1108	the developed functional membrane	1076:1108	the developed functional membrane	1076:1108	The adsorption/desorption curve of the developed functional membrane showed type II isotherm with a H3 hysteresis loop.
33034858	7	33	theme	adsorption/desorption	1045:1065	arg1	curve					1067:1071	The adsorption/desorption curve	1041:1071	The adsorption/desorption curve of the developed functional membrane	1041:1108	The adsorption/desorption curve of the developed functional membrane showed type II isotherm with a H3 hysteresis loop.
33034858	3	34	dep	peroxide	456:463	arg1	wt/wt					486:490	wt/wt	486:490	wt/wt	486:490	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	3	34	dep	peroxide	456:463	arg1	H2O2					480:483	0.5% H2O2	475:483	0.5% H2O2	475:483	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	3	34	dep	peroxide	456:463	arg1	NaOH					499:502	1% NaOH	496:502	1% NaOH	496:502	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	0	35	theme	silica	22:27	arg1	Recovery					0:7	Recovery	0:7	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.	0:150	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.
33034858	8	36	theme	membrane	1217:1224	arg1	400.3 m2/g					1230:1239	400.3 m2/g	1230:1239	400.3 m2/g	1230:1239	The observed Brunauer-Emmett-Teller surface area of the membrane was 400.3 m2/g.
33034858	8	36	theme	membrane	1217:1224	arg1	area					1205:1208	The observed Brunauer-Emmett-Teller surface area	1161:1208	The observed Brunauer-Emmett-Teller surface area of the membrane	1161:1224	The observed Brunauer-Emmett-Teller surface area of the membrane was 400.3 m2/g.
33034858	0	37	theme	membrane	119:126	arg1	fabrication					94:104	fabrication	94:104	fabrication of composite membrane for water purification	94:149	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.
33034858	2	38	theme	acid	327:330	arg1	catalyst					332:339	an acid catalyst	324:339	an acid catalyst (H2SO4 0.5%, wt/wt) to separate sugars after pre-treatment of biomass with ethanol	324:422	Bagasse saccharification was carried out with an acid catalyst (H2SO4 0.5%, wt/wt) to separate sugars after pre-treatment of biomass with ethanol.
33034858	2	38	theme	acid	327:330	arg1	wt/wt					354:358	H2SO4 0.5%, wt/wt	342:358	wt/wt	354:358	Bagasse saccharification was carried out with an acid catalyst (H2SO4 0.5%, wt/wt) to separate sugars after pre-treatment of biomass with ethanol.
33034858	10	39	theme	developed	1371:1379	arg1	process					1404:1410	the developed simple and sustainable process	1367:1410	the developed simple and sustainable process	1367:1410	Hence, the developed simple and sustainable process could be highly suitable for filtration of contaminated water and air purification.
33034858	10	39	theme	developed	1371:1379	arg1	suitable					1428:1435	suitable	1428:1435	suitable	1428:1435	Hence, the developed simple and sustainable process could be highly suitable for filtration of contaminated water and air purification.
33034858	6	40	theme	strong	946:951	arg1	membrane					984:991	strong as well as flexible functional membrane	946:991	strong as well as flexible functional membrane	946:991	Obtained silica and lignin nanomaterials were used in the fabrication of strong as well as flexible functional membrane for purification of solute particles and gases.
33034858	0	41	theme	nanosized	12:20	arg1	silica					22:27	nanosized silica	12:27	nanosized silica	12:27	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.
33034858	0	42	theme	composite	109:117	arg1	membrane					119:126	composite membrane	109:126	composite membrane	109:126	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.
33034858	5	43	theme	materials	802:810	arg1	ζ					780:780	ζ	780:780	ζ	780:780	Zeta potential (ζ) of the synthesised materials was found to be - 35.6 mV for SiO2 and - 13.1 mV for lignin.
33034858	5	43	theme	materials	802:810	arg1	potential					769:777	Zeta potential	764:777	Zeta potential (ζ) of the synthesised materials	764:810	Zeta potential (ζ) of the synthesised materials was found to be - 35.6 mV for SiO2 and - 13.1 mV for lignin.
33034858	3	44	theme	base	469:472	arg1	combination					441:451	a combination	439:451	a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt)	439:510	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	0	45	theme	lignin	33:38	arg1	Recovery					0:7	Recovery	0:7	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.	0:150	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.
33034858	6	46	theme	particles	1020:1028	arg1	purification					997:1008	purification	997:1008	purification of solute particles and gases	997:1038	Obtained silica and lignin nanomaterials were used in the fabrication of strong as well as flexible functional membrane for purification of solute particles and gases.
33034858	0	47	theme	water	132:136	arg1	purification					138:149	water purification	132:149	water purification	132:149	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.
33034858	4	48	theme	functional	725:734	arg1	materials					736:744	highly pure functional materials	713:744	highly pure functional materials	713:744	In the final step, precipitation using catalyst was completed to separate highly pure functional materials in powdered form.
33034858	8	49	theme	surface	1197:1203	arg1	400.3 m2/g					1230:1239	400.3 m2/g	1230:1239	400.3 m2/g	1230:1239	The observed Brunauer-Emmett-Teller surface area of the membrane was 400.3 m2/g.
33034858	8	49	theme	surface	1197:1203	arg1	area					1205:1208	The observed Brunauer-Emmett-Teller surface area	1161:1208	The observed Brunauer-Emmett-Teller surface area of the membrane	1161:1224	The observed Brunauer-Emmett-Teller surface area of the membrane was 400.3 m2/g.
33034858	6	50	theme	flexible	964:971	arg1	membrane					984:991	strong as well as flexible functional membrane	946:991	strong as well as flexible functional membrane	946:991	Obtained silica and lignin nanomaterials were used in the fabrication of strong as well as flexible functional membrane for purification of solute particles and gases.
33034858	3	51	theme	%	572:572	arg1	yield					574:578	5.65% yield	568:578	5.65% yield	568:578	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	0	52	from	waste	63:67	arg1	Recovery					0:7	Recovery	0:7	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.	0:150	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.
33034858	0	52	from	waste	63:67	arg1	fabrication					94:104	fabrication	94:104	fabrication of composite membrane for water purification	94:149	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.
33034858	4	53	theme	pure	720:723	arg1	materials					736:744	highly pure functional materials	713:744	highly pure functional materials	713:744	In the final step, precipitation using catalyst was completed to separate highly pure functional materials in powdered form.
33034858	5	54	theme	Zeta	764:767	arg1	ζ					780:780	ζ	780:780	ζ	780:780	Zeta potential (ζ) of the synthesised materials was found to be - 35.6 mV for SiO2 and - 13.1 mV for lignin.
33034858	5	54	theme	Zeta	764:767	arg1	potential					769:777	Zeta potential	764:777	Zeta potential (ζ) of the synthesised materials	764:810	Zeta potential (ζ) of the synthesised materials was found to be - 35.6 mV for SiO2 and - 13.1 mV for lignin.
33034858	2	55	theme	biomass	403:409	arg1	pre-treatment					386:398	pre-treatment	386:398	pre-treatment of biomass with ethanol	386:422	Bagasse saccharification was carried out with an acid catalyst (H2SO4 0.5%, wt/wt) to separate sugars after pre-treatment of biomass with ethanol.
33034858	0	56	theme	sugarcane	45:53	arg1	waste					63:67	sugarcane bagasse waste	45:67	sugarcane bagasse waste	45:67	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.
33034858	8	57	theme	observed	1165:1172	arg1	400.3 m2/g					1230:1239	400.3 m2/g	1230:1239	400.3 m2/g	1230:1239	The observed Brunauer-Emmett-Teller surface area of the membrane was 400.3 m2/g.
33034858	8	57	theme	observed	1165:1172	arg1	area					1205:1208	The observed Brunauer-Emmett-Teller surface area	1161:1208	The observed Brunauer-Emmett-Teller surface area of the membrane	1161:1224	The observed Brunauer-Emmett-Teller surface area of the membrane was 400.3 m2/g.
33034858	4	58	from	form	758:761	arg1	separate					704:711	separate	704:711	separate	704:711	In the final step, precipitation using catalyst was completed to separate highly pure functional materials in powdered form.
33034858	3	59	theme	%	478:478	arg1	wt/wt					486:490	wt/wt	486:490	wt/wt	486:490	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	3	59	theme	%	478:478	arg1	H2O2					480:483	0.5% H2O2	475:483	0.5% H2O2	475:483	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	3	59	theme	%	478:478	arg1	NaOH					499:502	1% NaOH	496:502	1% NaOH	496:502	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	9	60	dep	size	1251:1254	arg1	recorded					1275:1282	recorded	1275:1282	recorded by Barrett-Joyner-Halenda method	1275:1315	The pore size and pore volume as recorded by Barrett-Joyner-Halenda method was 25.5 nm and 0.624 cm3/g, respectively.
33034858	7	61	theme	membrane	1101:1108	arg1	curve					1067:1071	The adsorption/desorption curve	1041:1071	The adsorption/desorption curve of the developed functional membrane	1041:1108	The adsorption/desorption curve of the developed functional membrane showed type II isotherm with a H3 hysteresis loop.
33034858	2	62	theme	%	351:351	arg1	catalyst					332:339	an acid catalyst	324:339	an acid catalyst (H2SO4 0.5%, wt/wt) to separate sugars after pre-treatment of biomass with ethanol	324:422	Bagasse saccharification was carried out with an acid catalyst (H2SO4 0.5%, wt/wt) to separate sugars after pre-treatment of biomass with ethanol.
33034858	2	62	theme	%	351:351	arg1	wt/wt					354:358	H2SO4 0.5%, wt/wt	342:358	wt/wt	354:358	Bagasse saccharification was carried out with an acid catalyst (H2SO4 0.5%, wt/wt) to separate sugars after pre-treatment of biomass with ethanol.
33034858	3	63	theme	10.15	604:608	arg1	%					609:609	%	609:609	%	609:609	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	3	64	theme	5.65	568:571	arg1	%					572:572	%	572:572	%	572:572	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	6	65	theme	solute	1013:1018	arg1	particles					1020:1028	solute particles	1013:1028	solute particles	1013:1028	Obtained silica and lignin nanomaterials were used in the fabrication of strong as well as flexible functional membrane for purification of solute particles and gases.
33034858	9	66	theme	Barrett-Joyner-Halenda	1287:1308	arg1	method					1310:1315	Barrett-Joyner-Halenda method	1287:1315	Barrett-Joyner-Halenda method	1287:1315	The pore size and pore volume as recorded by Barrett-Joyner-Halenda method was 25.5 nm and 0.624 cm3/g, respectively.
33034858	1	67	theme	sugarcane	229:237	arg1	bagasse					239:245	sugarcane bagasse	229:245	sugarcane bagasse	229:245	Environmental benign catalytic process was developed for the valorisation of sugarcane bagasse into functional nanomaterials.
33034858	2	68	theme	Bagasse	278:284	arg1	saccharification					286:301	Bagasse saccharification	278:301	Bagasse saccharification	278:301	Bagasse saccharification was carried out with an acid catalyst (H2SO4 0.5%, wt/wt) to separate sugars after pre-treatment of biomass with ethanol.
33034858	2	69	theme	H2SO4	342:346	arg1	catalyst					332:339	an acid catalyst	324:339	an acid catalyst (H2SO4 0.5%, wt/wt) to separate sugars after pre-treatment of biomass with ethanol	324:422	Bagasse saccharification was carried out with an acid catalyst (H2SO4 0.5%, wt/wt) to separate sugars after pre-treatment of biomass with ethanol.
33034858	2	69	theme	H2SO4	342:346	arg1	wt/wt					354:358	H2SO4 0.5%, wt/wt	342:358	wt/wt	354:358	Bagasse saccharification was carried out with an acid catalyst (H2SO4 0.5%, wt/wt) to separate sugars after pre-treatment of biomass with ethanol.
33034858	1	70	theme	bagasse	239:245	arg1	valorisation					213:224	the valorisation	209:224	the valorisation of sugarcane bagasse into functional nanomaterials	209:275	Environmental benign catalytic process was developed for the valorisation of sugarcane bagasse into functional nanomaterials.
33034858	3	71	with	35 nm	557:561	arg1	yield					574:578	5.65% yield	568:578	5.65% yield	568:578	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	0	72	from	engineering	79:89	arg1	Recovery					0:7	Recovery	0:7	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.	0:150	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.
33034858	0	72	from	engineering	79:89	arg1	fabrication					94:104	fabrication	94:104	fabrication of composite membrane for water purification	94:149	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.
33034858	8	73	theme	Brunauer-Emmett-Teller	1174:1195	arg1	400.3 m2/g					1230:1239	400.3 m2/g	1230:1239	400.3 m2/g	1230:1239	The observed Brunauer-Emmett-Teller surface area of the membrane was 400.3 m2/g.
33034858	8	73	theme	Brunauer-Emmett-Teller	1174:1195	arg1	area					1205:1208	The observed Brunauer-Emmett-Teller surface area	1161:1208	The observed Brunauer-Emmett-Teller surface area of the membrane	1161:1224	The observed Brunauer-Emmett-Teller surface area of the membrane was 400.3 m2/g.
33034858	4	74	from	separate	704:711	arg1	form					758:761	powdered form	749:761	powdered form	749:761	In the final step, precipitation using catalyst was completed to separate highly pure functional materials in powdered form.
33034858	2	75	theme	separate	364:371	arg1	sugars					373:378	separate sugars	364:378	separate sugars	364:378	Bagasse saccharification was carried out with an acid catalyst (H2SO4 0.5%, wt/wt) to separate sugars after pre-treatment of biomass with ethanol.
33034858	0	76	theme	bagasse	55:61	arg1	waste					63:67	sugarcane bagasse waste	45:67	sugarcane bagasse waste	45:67	Recovery of nanosized silica and lignin from sugarcane bagasse waste and their engineering in fabrication of composite membrane for water purification.
33034858	3	77	dep	lignin	585:590	arg1	20 nm					593:597	20 nm	593:597	20 nm	593:597	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	3	78	theme	1	496:496	arg1	%					497:497	%	497:497	%	497:497	Subsequently, a combination of peroxide and base (0.5% H2O2, wt/wt and 1% NaOH, wt/wt) was stacked to concurrently synthesise SiO2 (35 nm with 5.65% yield) and lignin (20 nm with 10.15% yield) from bagasse slurry.
33034858	7	79	theme	H3	1141:1142	arg1	loop					1155:1158	a H3 hysteresis loop	1139:1158	a H3 hysteresis loop	1139:1158	The adsorption/desorption curve of the developed functional membrane showed type II isotherm with a H3 hysteresis loop.
33034858	1	80	theme	functional	252:261	arg1	nanomaterials					263:275	functional nanomaterials	252:275	functional nanomaterials	252:275	Environmental benign catalytic process was developed for the valorisation of sugarcane bagasse into functional nanomaterials.
32623092	9	0	theme	A-type	1560:1565	arg1	chains					1574:1579	short A-type glucan chains	1554:1579	short A-type glucan chains (<10 DP)	1554:1588	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	9	0	theme	A-type	1560:1565	arg1	DP					1586:1587	<10 DP	1582:1587	<10 DP	1582:1587	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	5	1	theme	single-nucleotide	647:663	arg1	substitution					671:682	a single-nucleotide A > G substitution	645:682	a single-nucleotide A > G substitution at the position 2612	645:703	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	9	2	theme	fine	1455:1458	arg1	structure					1460:1468	amylopectin fine structure	1443:1468	amylopectin fine structure	1443:1468	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	9	3	theme	chains	1574:1579	arg1	fraction					1542:1549	an increased fraction	1529:1549	an increased fraction of short A-type glucan chains (<10 DP)	1529:1588	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	9	3	theme	chains	1574:1579	arg1	fraction					1604:1611	decreased fraction	1594:1611	decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation	1594:1676	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	2	4	theme	uzu	288:290	arg1	mutation					292:299	the uzu mutation	284:299	the uzu mutation	284:299	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	9	5	theme	BRI-1	1415:1419	arg1	mutation					1421:1428	The BRI-1 mutation	1411:1428	The BRI-1 mutation	1411:1428	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	2	6	theme	starch	319:324	arg1	distribution					339:350	altered starch granule size distribution	311:350	altered starch granule size distribution	311:350	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	5	7	theme	kinase	819:824	arg1	domain					826:831	the kinase domain	815:831	the kinase domain of the respective polypeptide	815:861	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	5	7	theme	kinase	819:824	arg1	polypeptide					851:861	the respective polypeptide	836:861	the respective polypeptide	836:861	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	6	8	theme	grain	911:915	arg1	development					889:899	the development	885:899	the development of barley grain	885:915	The study focused on the development of barley grain, accumulation of starch and composition influenced by defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168).
32623092	8	9	contain	carrying	1235:1242	arg1	lines					1212:1216	The barley breeding lines 116, 144 and 168	1192:1233	The barley breeding lines 116, 144 and 168	1192:1233	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	8	9	contain	carrying	1235:1242	arg2	BRI-1					1257:1261	the aberrant BRI-1	1244:1261	the aberrant BRI-1	1244:1261	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	3	10	with	KK-2	365:368	arg1	Kendall					397:403	a barley genotype CDC Kendall	375:403	a barley genotype CDC Kendall	375:403	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules produced progeny lines (116, 144 and 168) with almost uni-modal starch granules.
32623092	3	10	with	KK-2	365:368	arg1	granules					426:433	bi-modal starch granules	410:433	bi-modal starch granules	410:433	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules produced progeny lines (116, 144 and 168) with almost uni-modal starch granules.
32623092	8	11	theme	breeding	1203:1210	arg1	lines					1212:1216	The barley breeding lines 116, 144 and 168	1192:1233	The barley breeding lines 116, 144 and 168	1192:1233	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	2	12	theme	genotype	240:247	arg1	KK-2					269:272	KK-2	269:272	KK-2	269:272	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	2	12	theme	genotype	240:247	arg1	Kyoshinkai-2					255:266	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2	210:266	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation	210:299	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	2	12	theme	genotype	240:247	arg1	vulgare					228:234	Hordeum vulgare L.	220:237	Hordeum vulgare L.	220:237	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	5	13	theme	subdomain	799:807	arg1	IV					809:810	subdomain IV	799:810	subdomain IV of the kinase domain of the respective polypeptide	799:861	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	9	14	theme	chains	1619:1624	arg1	fraction					1542:1549	an increased fraction	1529:1549	an increased fraction of short A-type glucan chains (<10 DP)	1529:1588	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	9	14	theme	chains	1619:1624	arg1	fraction					1604:1611	decreased fraction	1594:1611	decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation	1594:1676	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	5	15	from	residue	784:790	arg1	CGC					776:778	CGC	776:778	CGC	776:778	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	5	15	from	residue	784:790	arg1	Arg					771:773	Arg	771:773	Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide	771:861	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	1	16	theme	plant-based	122:132	arg1	steroids					134:141	plant-based steroids	122:141	plant-based steroids which influence several morphogenetic and developmental processes	122:207	Brassinosteroids (BR) are plant-based steroids which influence several morphogenetic and developmental processes.
32623092	1	16	theme	plant-based	122:132	arg1	Brassinosteroids					96:111	Brassinosteroids	96:111	Brassinosteroids (BR)	96:116	Brassinosteroids (BR) are plant-based steroids which influence several morphogenetic and developmental processes.
32623092	8	17	theme	amylose	1388:1394	arg1	concentration					1396:1408	amylose concentration	1388:1408	amylose concentration	1388:1408	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	10	18	theme	BR	1713:1714	arg1	influence					1700:1708	the influence	1696:1708	the influence of BR on barley grain development, starch accumulation, granule size distribution and amylopectin structure	1696:1816	The results show the influence of BR on barley grain development, starch accumulation, granule size distribution and amylopectin structure.
32623092	8	19	from	differences	1373:1383	arg1	concentration					1396:1408	amylose concentration	1388:1408	amylose concentration	1388:1408	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	1	20	theme	several	159:165	arg1	processes					199:207	several morphogenetic and developmental processes	159:207	several morphogenetic and developmental processes	159:207	Brassinosteroids (BR) are plant-based steroids which influence several morphogenetic and developmental processes.
32623092	6	21	theme	composition	945:955	arg1	accumulation					918:929	accumulation	918:929	accumulation of starch and composition	918:955	The study focused on the development of barley grain, accumulation of starch and composition influenced by defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168).
32623092	5	22	theme	respective	840:849	arg1	polypeptide					851:861	the respective polypeptide	836:861	the respective polypeptide	836:861	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	6	23	theme	starch	934:939	arg1	accumulation					918:929	accumulation	918:929	accumulation of starch and composition	918:955	The study focused on the development of barley grain, accumulation of starch and composition influenced by defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168).
32623092	5	24	theme	receptor-1	612:621	arg1	gene					631:634	the BR receptor-1 (BRI-1) gene	605:634	the BR receptor-1 (BRI-1) gene	605:634	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	9	25	from	fraction	1604:1611	arg1	genotypes					1640:1648	genotypes	1640:1648	genotypes carrying the BRI-1 mutation	1640:1676	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	7	26	theme	grain	1113:1117	arg1	development					1119:1129	grain development	1113:1129	grain development	1113:1129	Aberrant BRI-1 delayed grain development, amylose synthesis and starch accumulation in the endosperm.
32623092	5	27	theme	DNA	580:582	arg1	analysis					593:600	DNA sequence analysis	580:600	DNA sequence analysis of the BR receptor-1 (BRI-1) gene	580:634	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	8	28	theme	granule	1282:1288	arg1	distribution					1295:1306	altered granule size distribution	1274:1306	altered granule size distribution	1274:1306	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	3	29	theme	progeny	444:450	arg1	lines					452:456	progeny lines	444:456	progeny lines (116, 144 and 168)	444:475	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules produced progeny lines (116, 144 and 168) with almost uni-modal starch granules.
32623092	0	30	theme	Brassinosteroid	0:14	arg1	mutation					25:32	Brassinosteroid receptor mutation	0:32	Brassinosteroid receptor mutation	0:32	Brassinosteroid receptor mutation influences starch granule size distribution in barley grains.
32623092	2	31	contain	carrying	275:282	arg1	KK-2					269:272	KK-2	269:272	KK-2	269:272	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	2	31	contain	carrying	275:282	arg2	mutation					292:299	the uzu mutation	284:299	the uzu mutation	284:299	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	2	31	contain	carrying	275:282	arg1	Kyoshinkai-2					255:266	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2	210:266	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation	210:299	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	2	31	contain	carrying	275:282	arg1	vulgare					228:234	Hordeum vulgare L.	220:237	Hordeum vulgare L.	220:237	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	9	32	theme	small	1493:1497	arg1	granules					1506:1513	type small starch granules	1488:1513	type small starch granules	1488:1513	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	3	33	theme	genotype	384:391	arg1	Kendall					397:403	a barley genotype CDC Kendall	375:403	a barley genotype CDC Kendall	375:403	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules produced progeny lines (116, 144 and 168) with almost uni-modal starch granules.
32623092	4	34	theme	defective	555:563	arg1	perception					568:577	defective BR perception	555:577	defective BR perception	555:577	Bioassays correlated uzu mutation with defective BR perception.
32623092	5	35	theme	domain	826:831	arg1	IV					809:810	subdomain IV	799:810	subdomain IV of the kinase domain of the respective polypeptide	799:861	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	8	36	theme	significant	1313:1323	arg1	shift					1325:1329	significant shift	1313:1329	significant shift in the diameter maxima, but insignificant differences in amylose concentration	1313:1408	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	0	37	theme	starch	45:50	arg1	distribution					65:76	starch granule size distribution	45:76	starch granule size distribution in barley grains	45:93	Brassinosteroid receptor mutation influences starch granule size distribution in barley grains.
32623092	3	38	dep	lines	452:456	arg1	144					464:466	144	464:466	144	464:466	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules produced progeny lines (116, 144 and 168) with almost uni-modal starch granules.
32623092	3	38	dep	lines	452:456	arg1	168					472:474	168	472:474	168	472:474	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules produced progeny lines (116, 144 and 168) with almost uni-modal starch granules.
32623092	6	39	theme	BR	981:982	arg1	perception					984:993	defective BR perception	971:993	defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168)	971:1087	The study focused on the development of barley grain, accumulation of starch and composition influenced by defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168).
32623092	3	40	theme	bi-modal	410:417	arg1	granules					426:433	bi-modal starch granules	410:433	bi-modal starch granules	410:433	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules produced progeny lines (116, 144 and 168) with almost uni-modal starch granules.
32623092	7	41	theme	starch	1154:1159	arg1	accumulation					1161:1172	starch accumulation	1154:1172	starch accumulation	1154:1172	Aberrant BRI-1 delayed grain development, amylose synthesis and starch accumulation in the endosperm.
32623092	0	42	theme	size	60:63	arg1	distribution					65:76	starch granule size distribution	45:76	starch granule size distribution in barley grains	45:93	Brassinosteroid receptor mutation influences starch granule size distribution in barley grains.
32623092	9	43	from	genotypes	1640:1648	arg1	fraction					1542:1549	an increased fraction	1529:1549	an increased fraction of short A-type glucan chains (<10 DP)	1529:1588	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	9	43	from	genotypes	1640:1648	arg1	fraction					1604:1611	decreased fraction	1594:1611	decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation	1594:1676	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	2	44	theme	Hordeum	220:226	arg1	Kyoshinkai-2					255:266	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2	210:266	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation	210:299	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	2	44	theme	Hordeum	220:226	arg1	vulgare					228:234	Hordeum vulgare L.	220:237	Hordeum vulgare L.	220:237	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	8	45	theme	diameter	1338:1345	arg1	maxima					1347:1352	the diameter maxima	1334:1352	the diameter maxima	1334:1352	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	6	46	theme	barley-breeding	1048:1062	arg1	lines					1064:1068	three other barley-breeding lines	1036:1068	three other barley-breeding lines (116, 144 and 168)	1036:1087	The study focused on the development of barley grain, accumulation of starch and composition influenced by defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168).
32623092	2	47	theme	barley	212:217	arg1	KK-2					269:272	KK-2	269:272	KK-2	269:272	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	2	47	theme	barley	212:217	arg1	Kyoshinkai-2					255:266	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2	210:266	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation	210:299	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	2	47	theme	barley	212:217	arg1	vulgare					228:234	Hordeum vulgare L.	220:237	Hordeum vulgare L.	220:237	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	9	48	theme	short	1554:1558	arg1	chains					1574:1579	short A-type glucan chains	1554:1579	short A-type glucan chains (<10 DP)	1554:1588	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	9	48	theme	short	1554:1558	arg1	DP					1586:1587	<10 DP	1582:1587	<10 DP	1582:1587	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	7	49	theme	amylose	1132:1138	arg1	synthesis					1140:1148	amylose synthesis	1132:1148	amylose synthesis	1132:1148	Aberrant BRI-1 delayed grain development, amylose synthesis and starch accumulation in the endosperm.
32623092	3	50	theme	starch	499:504	arg1	granules					506:513	almost uni-modal starch granules	482:513	almost uni-modal starch granules	482:513	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules produced progeny lines (116, 144 and 168) with almost uni-modal starch granules.
32623092	9	51	theme	glucan	1567:1572	arg1	chains					1574:1579	short A-type glucan chains	1554:1579	short A-type glucan chains (<10 DP)	1554:1588	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	9	51	theme	glucan	1567:1572	arg1	DP					1586:1587	<10 DP	1582:1587	<10 DP	1582:1587	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	10	52	theme	barley	1719:1724	arg1	development					1732:1742	barley grain development	1719:1742	barley grain development	1719:1742	The results show the influence of BR on barley grain development, starch accumulation, granule size distribution and amylopectin structure.
32623092	10	53	theme	size	1774:1777	arg1	distribution					1779:1790	granule size distribution	1766:1790	granule size distribution	1766:1790	The results show the influence of BR on barley grain development, starch accumulation, granule size distribution and amylopectin structure.
32623092	5	54	theme	A > G	665:669	arg1	substitution					671:682	a single-nucleotide A > G substitution	645:682	a single-nucleotide A > G substitution at the position 2612	645:703	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	9	55	contain	carrying	1650:1657	arg1	genotypes					1640:1648	genotypes	1640:1648	genotypes carrying the BRI-1 mutation	1640:1676	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	9	55	contain	carrying	1650:1657	arg2	mutation					1669:1676	the BRI-1 mutation	1659:1676	the BRI-1 mutation	1659:1676	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	5	56	theme	BRI-1	624:628	arg1	gene					631:634	the BR receptor-1 (BRI-1) gene	605:634	the BR receptor-1 (BRI-1) gene	605:634	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	8	57	from	shift	1325:1329	arg1	differences					1373:1383	insignificant differences	1359:1383	insignificant differences in amylose concentration	1359:1408	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	8	57	from	shift	1325:1329	arg1	maxima					1347:1352	the diameter maxima	1334:1352	the diameter maxima	1334:1352	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	1	58	theme	developmental	185:197	arg1	processes					199:207	several morphogenetic and developmental processes	159:207	several morphogenetic and developmental processes	159:207	Brassinosteroids (BR) are plant-based steroids which influence several morphogenetic and developmental processes.
32623092	5	59	theme	gene	631:634	arg1	analysis					593:600	DNA sequence analysis	580:600	DNA sequence analysis of the BR receptor-1 (BRI-1) gene	580:634	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	2	60	theme	granule	326:332	arg1	distribution					339:350	altered starch granule size distribution	311:350	altered starch granule size distribution	311:350	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	2	61	theme	altered	311:317	arg1	distribution					339:350	altered starch granule size distribution	311:350	altered starch granule size distribution	311:350	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	6	62	theme	barley	904:909	arg1	grain					911:915	barley grain	904:915	barley grain	904:915	The study focused on the development of barley grain, accumulation of starch and composition influenced by defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168).
32623092	8	63	theme	insignificant	1359:1371	arg1	differences					1373:1383	insignificant differences	1359:1383	insignificant differences in amylose concentration	1359:1408	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	5	64	theme	kinase	712:717	arg1	domain					719:724	the kinase domain	708:724	the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide	708:861	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	2	65	theme	Kinai	249:253	arg1	KK-2					269:272	KK-2	269:272	KK-2	269:272	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	2	65	theme	Kinai	249:253	arg1	Kyoshinkai-2					255:266	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2	210:266	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation	210:299	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	2	65	theme	Kinai	249:253	arg1	vulgare					228:234	Hordeum vulgare L.	220:237	Hordeum vulgare L.	220:237	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	9	66	theme	B2	1616:1617	arg1	chains					1619:1624	B2 chains	1616:1624	B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation	1616:1676	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	9	66	theme	B2	1616:1617	arg1	DP					1633:1634	25-36 DP	1627:1634	25-36 DP	1627:1634	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	8	67	theme	barley	1196:1201	arg1	lines					1212:1216	The barley breeding lines 116, 144 and 168	1192:1233	The barley breeding lines 116, 144 and 168	1192:1233	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	5	68	theme	polypeptide	851:861	arg1	domain					826:831	the kinase domain	815:831	the kinase domain of the respective polypeptide	815:861	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	5	68	theme	polypeptide	851:861	arg1	polypeptide					851:861	the respective polypeptide	836:861	the respective polypeptide	836:861	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	9	69	theme	decreased	1594:1602	arg1	fraction					1604:1611	decreased fraction	1594:1611	decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation	1594:1676	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	5	70	theme	position	691:698	arg1	2612					700:703	the position 2612	687:703	the position 2612	687:703	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	6	71	dep	lines	1064:1068	arg1	168					1084:1086	168	1084:1086	168	1084:1086	The study focused on the development of barley grain, accumulation of starch and composition influenced by defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168).
32623092	6	71	dep	lines	1064:1068	arg1	144					1076:1078	144	1076:1078	144	1076:1078	The study focused on the development of barley grain, accumulation of starch and composition influenced by defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168).
32623092	6	72	theme	defective	971:979	arg1	perception					984:993	defective BR perception	971:993	defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168)	971:1087	The study focused on the development of barley grain, accumulation of starch and composition influenced by defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168).
32623092	9	73	dep	B-	1478:1479	arg1	granules					1506:1513	type small starch granules	1488:1513	type small starch granules	1488:1513	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	0	74	theme	barley	81:86	arg1	grains					88:93	barley grains	81:93	barley grains	81:93	Brassinosteroid receptor mutation influences starch granule size distribution in barley grains.
32623092	9	75	theme	amylopectin	1443:1453	arg1	structure					1460:1468	amylopectin fine structure	1443:1468	amylopectin fine structure	1443:1468	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	9	76	from	chains	1619:1624	arg1	genotypes					1640:1648	genotypes	1640:1648	genotypes carrying the BRI-1 mutation	1640:1676	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	3	77	theme	Hybridizing	353:363	arg1	KK-2					365:368	Hybridizing KK-2	353:368	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules	353:433	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules produced progeny lines (116, 144 and 168) with almost uni-modal starch granules.
32623092	9	78	theme	BRI-1	1663:1667	arg1	mutation					1669:1676	the BRI-1 mutation	1659:1676	the BRI-1 mutation	1659:1676	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	5	79	theme	His	758:760	arg1	change					748:753	the change	744:753	the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide	744:861	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	5	80	from	Arg	771:773	arg1	IV					809:810	subdomain IV	799:810	subdomain IV of the kinase domain of the respective polypeptide	799:861	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	1	81	theme	morphogenetic	167:179	arg1	processes					199:207	several morphogenetic and developmental processes	159:207	several morphogenetic and developmental processes	159:207	Brassinosteroids (BR) are plant-based steroids which influence several morphogenetic and developmental processes.
32623092	0	82	from	distribution	65:76	arg1	grains					88:93	barley grains	81:93	barley grains	81:93	Brassinosteroid receptor mutation influences starch granule size distribution in barley grains.
32623092	5	83	theme	BR	609:610	arg1	gene					631:634	the BR receptor-1 (BRI-1) gene	605:634	the BR receptor-1 (BRI-1) gene	605:634	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	3	84	theme	barley	377:382	arg1	Kendall					397:403	a barley genotype CDC Kendall	375:403	a barley genotype CDC Kendall	375:403	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules produced progeny lines (116, 144 and 168) with almost uni-modal starch granules.
32623092	6	85	located	detected	1015:1022	arg1	lines					1064:1068	three other barley-breeding lines	1036:1068	three other barley-breeding lines (116, 144 and 168)	1036:1087	The study focused on the development of barley grain, accumulation of starch and composition influenced by defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168).
32623092	6	85	located	detected	1015:1022	arg2	mutation					1006:1013	the mutation	1002:1013	the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168)	1002:1087	The study focused on the development of barley grain, accumulation of starch and composition influenced by defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168).
32623092	6	85	located	detected	1015:1022	arg1	KK-2					1027:1030	KK-2	1027:1030	KK-2	1027:1030	The study focused on the development of barley grain, accumulation of starch and composition influenced by defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168).
32623092	8	86	theme	aberrant	1248:1255	arg1	BRI-1					1257:1261	the aberrant BRI-1	1244:1261	the aberrant BRI-1	1244:1261	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	0	87	theme	receptor	16:23	arg1	mutation					25:32	Brassinosteroid receptor mutation	0:32	Brassinosteroid receptor mutation	0:32	Brassinosteroid receptor mutation influences starch granule size distribution in barley grains.
32623092	5	88	theme	sequence	584:591	arg1	analysis					593:600	DNA sequence analysis	580:600	DNA sequence analysis of the BR receptor-1 (BRI-1) gene	580:634	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	9	89	theme	type	1488:1491	arg1	granules					1506:1513	type small starch granules	1488:1513	type small starch granules	1488:1513	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	9	90	from	fraction	1542:1549	arg1	genotypes					1640:1648	genotypes	1640:1648	genotypes carrying the BRI-1 mutation	1640:1676	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	4	91	theme	BR	565:566	arg1	perception					568:577	defective BR perception	555:577	defective BR perception	555:577	Bioassays correlated uzu mutation with defective BR perception.
32623092	10	92	theme	starch	1745:1750	arg1	accumulation					1752:1763	starch accumulation	1745:1763	starch accumulation	1745:1763	The results show the influence of BR on barley grain development, starch accumulation, granule size distribution and amylopectin structure.
32623092	8	93	theme	altered	1274:1280	arg1	distribution					1295:1306	altered granule size distribution	1274:1306	altered granule size distribution	1274:1306	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	9	94	theme	starch	1499:1504	arg1	granules					1506:1513	type small starch granules	1488:1513	type small starch granules	1488:1513	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	10	95	from	influence	1700:1708	arg1	development					1732:1742	barley grain development	1719:1742	barley grain development	1719:1742	The results show the influence of BR on barley grain development, starch accumulation, granule size distribution and amylopectin structure.
32623092	10	95	from	influence	1700:1708	arg1	accumulation					1752:1763	starch accumulation	1745:1763	starch accumulation	1745:1763	The results show the influence of BR on barley grain development, starch accumulation, granule size distribution and amylopectin structure.
32623092	10	95	from	influence	1700:1708	arg1	distribution					1779:1790	granule size distribution	1766:1790	granule size distribution	1766:1790	The results show the influence of BR on barley grain development, starch accumulation, granule size distribution and amylopectin structure.
32623092	10	95	from	influence	1700:1708	arg1	structure					1808:1816	amylopectin structure	1796:1816	amylopectin structure	1796:1816	The results show the influence of BR on barley grain development, starch accumulation, granule size distribution and amylopectin structure.
32623092	3	96	theme	CDC	393:395	arg1	Kendall					397:403	a barley genotype CDC Kendall	375:403	a barley genotype CDC Kendall	375:403	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules produced progeny lines (116, 144 and 168) with almost uni-modal starch granules.
32623092	8	97	theme	size	1290:1293	arg1	distribution					1295:1306	altered granule size distribution	1274:1306	altered granule size distribution	1274:1306	The barley breeding lines 116, 144 and 168 carrying the aberrant BRI-1, exhibited altered granule size distribution with significant shift in the diameter maxima, but insignificant differences in amylose concentration.
32623092	0	98	theme	granule	52:58	arg1	distribution					65:76	starch granule size distribution	45:76	starch granule size distribution in barley grains	45:93	Brassinosteroid receptor mutation influences starch granule size distribution in barley grains.
32623092	4	99	theme	uzu	537:539	arg1	mutation					541:548	uzu mutation	537:548	uzu mutation	537:548	Bioassays correlated uzu mutation with defective BR perception.
32623092	10	100	theme	grain	1726:1730	arg1	development					1732:1742	barley grain development	1719:1742	barley grain development	1719:1742	The results show the influence of BR on barley grain development, starch accumulation, granule size distribution and amylopectin structure.
32623092	3	101	theme	starch	419:424	arg1	granules					426:433	bi-modal starch granules	410:433	bi-modal starch granules	410:433	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules produced progeny lines (116, 144 and 168) with almost uni-modal starch granules.
32623092	10	102	theme	granule	1766:1772	arg1	distribution					1779:1790	granule size distribution	1766:1790	granule size distribution	1766:1790	The results show the influence of BR on barley grain development, starch accumulation, granule size distribution and amylopectin structure.
32623092	3	103	theme	uni-modal	489:497	arg1	granules					506:513	almost uni-modal starch granules	482:513	almost uni-modal starch granules	482:513	Hybridizing KK-2 with a barley genotype CDC Kendall with bi-modal starch granules produced progeny lines (116, 144 and 168) with almost uni-modal starch granules.
32623092	9	104	theme	increased	1532:1540	arg1	fraction					1542:1549	an increased fraction	1529:1549	an increased fraction of short A-type glucan chains (<10 DP)	1529:1588	The BRI-1 mutation also altered amylopectin fine structure in both B- and C- type small starch granules, resulting in an increased fraction of short A-type glucan chains (<10 DP) and decreased fraction of B2 chains (25-36 DP) in genotypes carrying the BRI-1 mutation.
32623092	2	105	theme	size	334:337	arg1	distribution					339:350	altered starch granule size distribution	311:350	altered starch granule size distribution	311:350	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	5	106	from	2612	700:703	arg1	substitution					671:682	a single-nucleotide A > G substitution	645:682	a single-nucleotide A > G substitution at the position 2612	645:703	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.
32623092	6	107	theme	other	1042:1046	arg1	lines					1064:1068	three other barley-breeding lines	1036:1068	three other barley-breeding lines (116, 144 and 168)	1036:1087	The study focused on the development of barley grain, accumulation of starch and composition influenced by defective BR perception due to the mutation detected in KK-2 and three other barley-breeding lines (116, 144 and 168).
32623092	2	108	dep	vulgare	228:234	arg1	L.					236:237	L.	236:237	L.	236:237	A barley (Hordeum vulgare L.) genotype Kinai Kyoshinkai-2 (KK-2) carrying the uzu mutation exhibited altered starch granule size distribution.
32623092	10	109	theme	amylopectin	1796:1806	arg1	structure					1808:1816	amylopectin structure	1796:1816	amylopectin structure	1796:1816	The results show the influence of BR on barley grain development, starch accumulation, granule size distribution and amylopectin structure.
32623092	7	110	theme	Aberrant	1090:1097	arg1	BRI-1					1099:1103	Aberrant BRI-1	1090:1103	Aberrant BRI-1	1090:1103	Aberrant BRI-1 delayed grain development, amylose synthesis and starch accumulation in the endosperm.
32234599	6	0	theme	yield	1187:1191	arg1	values					1193:1198	their quantum yield values	1173:1198	their quantum yield values	1173:1198	Their reaction kinetic rates were estimated as 8.15 × 10-2 and 0.21 mmol/g/h, respectively (at the initial concentration of 10 mg/L), while their quantum yield values were 1.56 × 10-6 and 3.83 × 10-6 molecules per photon, respectively.
32234599	0	1	theme	pyrolysis	153:161	arg1	temperature					163:173	cellulose pyrolysis temperature	143:173	cellulose pyrolysis temperature	143:173	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	4	2	theme	temperature	637:647	arg1	effect					613:618	The effect	609:618	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF	609:774	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	1	3	theme	carbon	244:249	arg1	nanofibers					251:260	biomass cellulose-derived carbon nanofibers	218:260	biomass cellulose-derived carbon nanofibers (CCNF)	218:267	A series of biomass cellulose-derived carbon nanofibers (CCNF) were prepared at different pyrolysis temperatures in this study.
32234599	1	3	theme	carbon	244:249	arg1	CCNF					263:266	CCNF	263:266	CCNF	263:266	A series of biomass cellulose-derived carbon nanofibers (CCNF) were prepared at different pyrolysis temperatures in this study.
32234599	7	4	theme	oxygen	1409:1414	arg1	species					1416:1422	active oxidative and reductive oxygen species	1378:1422	active oxidative and reductive oxygen species	1378:1422	BiOBr/CCNF catalysts were efficient enough to simultaneously remove RhB and Cr(VI) through the generation of active oxidative and reductive oxygen species, respectively.
32234599	0	5	theme	cellulose	143:151	arg1	temperature					163:173	cellulose pyrolysis temperature	143:173	cellulose pyrolysis temperature	143:173	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	1	6	from	temperatures	306:317	arg1	study					327:331	this study	322:331	this study	322:331	A series of biomass cellulose-derived carbon nanofibers (CCNF) were prepared at different pyrolysis temperatures in this study.
32234599	0	7	dep	incorporated	91:102	arg1	effect					133:138	The effect	129:138	The effect of cellulose pyrolysis temperature on photocatalytic performance	129:203	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	1	8	theme	nanofibers	251:260	arg1	series					208:213	A series	206:213	A series of biomass cellulose-derived carbon nanofibers (CCNF)	206:267	A series of biomass cellulose-derived carbon nanofibers (CCNF) were prepared at different pyrolysis temperatures in this study.
32234599	0	9	theme	cellulose	64:72	arg1	nanofiber					81:89	cellulose carbon nanofiber	64:89	cellulose carbon nanofiber	64:89	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	7	10	theme	species	1416:1422	arg1	generation					1364:1373	the generation	1360:1373	the generation of active oxidative and reductive oxygen species	1360:1422	BiOBr/CCNF catalysts were efficient enough to simultaneously remove RhB and Cr(VI) through the generation of active oxidative and reductive oxygen species, respectively.
32234599	4	11	theme	photocatalytic	812:825	arg1	performance					827:837	its photocatalytic performance	808:837	its photocatalytic performance	808:837	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	8	12	link	derived	1550:1556	arg1	materials					1571:1579	biomass derived carbonaceous materials	1542:1579	biomass derived carbonaceous materials	1542:1579	The strategies used in this study offer a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water.
32234599	4	13	theme	functional	697:706	arg1	properties					656:665	the properties	652:665	the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF	652:774	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	13	theme	functional	697:706	arg1	distribution					714:725	functional group distribution	697:725	functional group distribution	697:725	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	5	14	theme	higher	898:903	arg1	degrees					905:911	higher degrees	898:911	higher degrees of graphitization which was accompanied by a better photocatalytic performance of its composite against RhB and Cr(VI)	898:1030	A pyrolysis temperature over 800 °C resulted in CCNF with higher degrees of graphitization which was accompanied by a better photocatalytic performance of its composite against RhB and Cr(VI).
32234599	0	15	theme	temperature	163:173	arg1	effect					133:138	The effect	129:138	The effect of cellulose pyrolysis temperature on photocatalytic performance	129:203	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	3	16	theme	rhodamine	536:544	arg1	RhB					549:551	RhB	549:551	RhB	549:551	The feasibility of BiOBr/CCNF as photocatalyst was investigated for the treatment against organic dye, rhodamine B (RhB) and inorganic metal ion, hexavalent chromium (Cr(VI)).
32234599	3	16	theme	rhodamine	536:544	arg1	B					546:546	rhodamine B	536:546	rhodamine B (RhB)	536:552	The feasibility of BiOBr/CCNF as photocatalyst was investigated for the treatment against organic dye, rhodamine B (RhB) and inorganic metal ion, hexavalent chromium (Cr(VI)).
32234599	2	17	theme	BiOBr/CCNF	411:420	arg1	composite					422:430	BiOBr/CCNF composite	411:430	BiOBr/CCNF composite	411:430	Subsequently, this CCNF was combined with bismuth oxybromide (BiOBr) to form BiOBr/CCNF composite.
32234599	8	18	theme	efficient	1589:1597	arg1	removal					1599:1605	the efficient removal	1585:1605	the efficient removal of multicomponent contaminants in water	1585:1645	The strategies used in this study offer a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water.
32234599	4	19	theme	pyrolysis	627:635	arg1	temperature					637:647	the pyrolysis temperature	623:647	the pyrolysis temperature	623:647	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	20	from	effect	613:618	arg1	degree					747:752	graphitization degree	732:752	graphitization degree	732:752	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	20	from	effect	613:618	arg1	properties					656:665	the properties	652:665	the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF	652:774	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	20	from	effect	613:618	arg1	structure					686:694	crystalline structure	674:694	crystalline structure	674:694	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	20	from	effect	613:618	arg1	distribution					714:725	functional group distribution	697:725	functional group distribution	697:725	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	7	21	dep	efficient	1295:1303	arg1	remove					1330:1335	remove	1330:1335	remove	1330:1335	BiOBr/CCNF catalysts were efficient enough to simultaneously remove RhB and Cr(VI) through the generation of active oxidative and reductive oxygen species, respectively.
32234599	3	22	theme	organic	523:529	arg1	chromium					590:597	hexavalent chromium	579:597	hexavalent chromium (Cr(VI))	579:606	The feasibility of BiOBr/CCNF as photocatalyst was investigated for the treatment against organic dye, rhodamine B (RhB) and inorganic metal ion, hexavalent chromium (Cr(VI)).
32234599	3	22	theme	organic	523:529	arg1	dye					531:533	organic dye	523:533	organic dye	523:533	The feasibility of BiOBr/CCNF as photocatalyst was investigated for the treatment against organic dye, rhodamine B (RhB) and inorganic metal ion, hexavalent chromium (Cr(VI)).
32234599	7	23	theme	BiOBr/CCNF	1269:1278	arg1	catalysts					1280:1288	BiOBr/CCNF catalysts	1269:1288	BiOBr/CCNF catalysts	1269:1288	BiOBr/CCNF catalysts were efficient enough to simultaneously remove RhB and Cr(VI) through the generation of active oxidative and reductive oxygen species, respectively.
32234599	0	24	theme	carbon	74:79	arg1	nanofiber					81:89	cellulose carbon nanofiber	64:89	cellulose carbon nanofiber	64:89	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	5	25	theme	pyrolysis	842:850	arg1	temperature					852:862	A pyrolysis temperature	840:862	A pyrolysis temperature over 800 °C	840:874	A pyrolysis temperature over 800 °C resulted in CCNF with higher degrees of graphitization which was accompanied by a better photocatalytic performance of its composite against RhB and Cr(VI).
32234599	0	26	theme	photocatalytic	178:191	arg1	performance					193:203	photocatalytic performance	178:203	photocatalytic performance	178:203	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	4	27	theme	group	708:712	arg1	properties					656:665	the properties	652:665	the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF	652:774	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	27	theme	group	708:712	arg1	distribution					714:725	functional group distribution	697:725	functional group distribution	697:725	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	2	28	theme	bismuth	376:382	arg1	BiOBr					396:400	BiOBr	396:400	BiOBr	396:400	Subsequently, this CCNF was combined with bismuth oxybromide (BiOBr) to form BiOBr/CCNF composite.
32234599	2	28	theme	bismuth	376:382	arg1	oxybromide					384:393	bismuth oxybromide	376:393	bismuth oxybromide (BiOBr)	376:401	Subsequently, this CCNF was combined with bismuth oxybromide (BiOBr) to form BiOBr/CCNF composite.
32234599	7	29	theme	oxidative	1385:1393	arg1	species					1416:1422	active oxidative and reductive oxygen species	1378:1422	active oxidative and reductive oxygen species	1378:1422	BiOBr/CCNF catalysts were efficient enough to simultaneously remove RhB and Cr(VI) through the generation of active oxidative and reductive oxygen species, respectively.
32234599	6	30	theme	quantum	1179:1185	arg1	yield					1187:1191	their quantum yield	1173:1191	their quantum yield values	1173:1198	Their reaction kinetic rates were estimated as 8.15 × 10-2 and 0.21 mmol/g/h, respectively (at the initial concentration of 10 mg/L), while their quantum yield values were 1.56 × 10-6 and 3.83 × 10-6 molecules per photon, respectively.
32234599	1	31	link	cellulose-derived	226:242	arg1	nanofibers					251:260	biomass cellulose-derived carbon nanofibers	218:260	biomass cellulose-derived carbon nanofibers (CCNF)	218:267	A series of biomass cellulose-derived carbon nanofibers (CCNF) were prepared at different pyrolysis temperatures in this study.
32234599	1	31	link	cellulose-derived	226:242	arg1	CCNF					263:266	CCNF	263:266	CCNF	263:266	A series of biomass cellulose-derived carbon nanofibers (CCNF) were prepared at different pyrolysis temperatures in this study.
32234599	5	32	dep	Cr	1025:1026	arg1	VI					1028:1029	VI	1028:1029	VI	1028:1029	A pyrolysis temperature over 800 °C resulted in CCNF with higher degrees of graphitization which was accompanied by a better photocatalytic performance of its composite against RhB and Cr(VI).
32234599	7	33	dep	Cr	1345:1346	arg1	VI					1348:1349	VI	1348:1349	VI	1348:1349	BiOBr/CCNF catalysts were efficient enough to simultaneously remove RhB and Cr(VI) through the generation of active oxidative and reductive oxygen species, respectively.
32234599	0	34	theme	Simultaneous	0:11	arg1	removal					13:19	Simultaneous removal	0:19	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber	0:89	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	7	35	theme	reductive	1399:1407	arg1	species					1416:1422	active oxidative and reductive oxygen species	1378:1422	active oxidative and reductive oxygen species	1378:1422	BiOBr/CCNF catalysts were efficient enough to simultaneously remove RhB and Cr(VI) through the generation of active oxidative and reductive oxygen species, respectively.
32234599	4	36	dep	properties	656:665	arg1	degree					747:752	graphitization degree	732:752	graphitization degree	732:752	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	36	dep	properties	656:665	arg1	properties					656:665	the properties	652:665	the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF	652:774	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	36	dep	properties	656:665	arg1	structure					686:694	crystalline structure	674:694	crystalline structure	674:694	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	36	dep	properties	656:665	arg1	distribution					714:725	functional group distribution	697:725	functional group distribution	697:725	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	0	37	theme	rhodamine	24:32	arg1	B					34:34	rhodamine B	24:34	rhodamine B	24:34	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	6	38	theme	10 mg/L	1157:1163	arg1	concentration					1140:1152	the initial concentration	1128:1152	the initial concentration of 10 mg/L	1128:1163	Their reaction kinetic rates were estimated as 8.15 × 10-2 and 0.21 mmol/g/h, respectively (at the initial concentration of 10 mg/L), while their quantum yield values were 1.56 × 10-6 and 3.83 × 10-6 molecules per photon, respectively.
32234599	5	39	theme	better	958:963	arg1	performance					980:990	a better photocatalytic performance	956:990	a better photocatalytic performance of its composite against RhB and Cr(VI)	956:1030	A pyrolysis temperature over 800 °C resulted in CCNF with higher degrees of graphitization which was accompanied by a better photocatalytic performance of its composite against RhB and Cr(VI).
32234599	5	40	with	CCNF	888:891	arg1	degrees					905:911	higher degrees	898:911	higher degrees of graphitization which was accompanied by a better photocatalytic performance of its composite against RhB and Cr(VI)	898:1030	A pyrolysis temperature over 800 °C resulted in CCNF with higher degrees of graphitization which was accompanied by a better photocatalytic performance of its composite against RhB and Cr(VI).
32234599	8	41	from	contaminants	1625:1636	arg1	water					1641:1645	water	1641:1645	water	1641:1645	The strategies used in this study offer a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water.
32234599	5	42	theme	graphitization	916:929	arg1	degrees					905:911	higher degrees	898:911	higher degrees of graphitization which was accompanied by a better photocatalytic performance of its composite against RhB and Cr(VI)	898:1030	A pyrolysis temperature over 800 °C resulted in CCNF with higher degrees of graphitization which was accompanied by a better photocatalytic performance of its composite against RhB and Cr(VI).
32234599	0	43	from	water	52:56	arg1	removal					13:19	Simultaneous removal	0:19	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber	0:89	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	4	44	theme	crystalline	674:684	arg1	structure					686:694	crystalline structure	674:694	crystalline structure	674:694	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	44	theme	crystalline	674:684	arg1	properties					656:665	the properties	652:665	the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF	652:774	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	3	45	theme	BiOBr/CCNF	452:461	arg1	feasibility					437:447	The feasibility	433:447	The feasibility of BiOBr/CCNF as photocatalyst	433:478	The feasibility of BiOBr/CCNF as photocatalyst was investigated for the treatment against organic dye, rhodamine B (RhB) and inorganic metal ion, hexavalent chromium (Cr(VI)).
32234599	8	46	from	water	1641:1645	arg1	removal					1599:1605	the efficient removal	1585:1605	the efficient removal of multicomponent contaminants in water	1585:1645	The strategies used in this study offer a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water.
32234599	3	47	theme	metal	568:572	arg1	ion					574:576	inorganic metal ion	558:576	inorganic metal ion	558:576	The feasibility of BiOBr/CCNF as photocatalyst was investigated for the treatment against organic dye, rhodamine B (RhB) and inorganic metal ion, hexavalent chromium (Cr(VI)).
32234599	0	48	theme	B	34:34	arg1	removal					13:19	Simultaneous removal	0:19	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber	0:89	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	1	49	theme	different	286:294	arg1	temperatures					306:317	different pyrolysis temperatures	286:317	different pyrolysis temperatures in this study	286:331	A series of biomass cellulose-derived carbon nanofibers (CCNF) were prepared at different pyrolysis temperatures in this study.
32234599	0	50	theme	bismuth	109:115	arg1	oxybromide					117:126	bismuth oxybromide	109:126	bismuth oxybromide	109:126	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	0	51	dep	Cr	40:41	arg1	VI					43:44	VI	43:44	VI	43:44	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	0	52	from	effect	133:138	arg1	performance					193:203	photocatalytic performance	178:203	photocatalytic performance	178:203	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	1	53	theme	pyrolysis	296:304	arg1	temperatures					306:317	different pyrolysis temperatures	286:317	different pyrolysis temperatures in this study	286:331	A series of biomass cellulose-derived carbon nanofibers (CCNF) were prepared at different pyrolysis temperatures in this study.
32234599	8	54	from	removal	1599:1605	arg1	water					1641:1645	water	1641:1645	water	1641:1645	The strategies used in this study offer a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water.
32234599	4	55	theme	prepared	762:769	arg1	CCNF					771:774	the prepared CCNF	758:774	the prepared CCNF	758:774	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	7	56	theme	active	1378:1383	arg1	species					1416:1422	active oxidative and reductive oxygen species	1378:1422	active oxidative and reductive oxygen species	1378:1422	BiOBr/CCNF catalysts were efficient enough to simultaneously remove RhB and Cr(VI) through the generation of active oxidative and reductive oxygen species, respectively.
32234599	4	57	dep	structure	686:694	arg1	e.g.					668:671	e.g., crystalline structure, functional group distribution, and graphitization degree	668:752	e.g.	668:671	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	0	58	theme	Cr	40:41	arg1	removal					13:19	Simultaneous removal	0:19	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber	0:89	Simultaneous removal of rhodamine B and Cr(VI) from water using cellulose carbon nanofiber incorporated with bismuth oxybromide: The effect of cellulose pyrolysis temperature on photocatalytic performance.
32234599	4	59	theme	CCNF	771:774	arg1	degree					747:752	graphitization degree	732:752	graphitization degree	732:752	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	59	theme	CCNF	771:774	arg1	properties					656:665	the properties	652:665	the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF	652:774	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	59	theme	CCNF	771:774	arg1	structure					686:694	crystalline structure	674:694	crystalline structure	674:694	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	59	theme	CCNF	771:774	arg1	distribution					714:725	functional group distribution	697:725	functional group distribution	697:725	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	8	60	theme	cost-effective	1507:1520	arg1	photocatalysts					1522:1535	cost-effective photocatalysts	1507:1535	cost-effective photocatalysts with biomass derived carbonaceous materials	1507:1579	The strategies used in this study offer a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water.
32234599	3	61	theme	inorganic	558:566	arg1	ion					574:576	inorganic metal ion	558:576	inorganic metal ion	558:576	The feasibility of BiOBr/CCNF as photocatalyst was investigated for the treatment against organic dye, rhodamine B (RhB) and inorganic metal ion, hexavalent chromium (Cr(VI)).
32234599	8	62	theme	multicomponent	1610:1623	arg1	contaminants					1625:1636	multicomponent contaminants	1610:1636	multicomponent contaminants in water	1610:1645	The strategies used in this study offer a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water.
32234599	4	63	theme	graphitization	732:745	arg1	degree					747:752	graphitization degree	732:752	graphitization degree	732:752	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	4	63	theme	graphitization	732:745	arg1	properties					656:665	the properties	652:665	the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF	652:774	The effect of the pyrolysis temperature on the properties (e.g., crystalline structure, functional group distribution, and graphitization degree) of the prepared CCNF was investigated in relation to its photocatalytic performance.
32234599	5	64	theme	composite	999:1007	arg1	performance					980:990	a better photocatalytic performance	956:990	a better photocatalytic performance of its composite against RhB and Cr(VI)	956:1030	A pyrolysis temperature over 800 °C resulted in CCNF with higher degrees of graphitization which was accompanied by a better photocatalytic performance of its composite against RhB and Cr(VI).
32234599	5	65	theme	photocatalytic	965:978	arg1	performance					980:990	a better photocatalytic performance	956:990	a better photocatalytic performance of its composite against RhB and Cr(VI)	956:1030	A pyrolysis temperature over 800 °C resulted in CCNF with higher degrees of graphitization which was accompanied by a better photocatalytic performance of its composite against RhB and Cr(VI).
32234599	3	66	dep	Cr	600:601	arg1	VI					603:604	VI	603:604	VI	603:604	The feasibility of BiOBr/CCNF as photocatalyst was investigated for the treatment against organic dye, rhodamine B (RhB) and inorganic metal ion, hexavalent chromium (Cr(VI)).
32234599	8	67	theme	new	1481:1483	arg1	pathway					1485:1491	a new pathway	1479:1491	a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water	1479:1645	The strategies used in this study offer a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water.
32234599	8	68	with	photocatalysts	1522:1535	arg1	materials					1571:1579	biomass derived carbonaceous materials	1542:1579	biomass derived carbonaceous materials	1542:1579	The strategies used in this study offer a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water.
32234599	6	69	theme	kinetic	1048:1054	arg1	rates					1056:1060	Their reaction kinetic rates	1033:1060	Their reaction kinetic rates	1033:1060	Their reaction kinetic rates were estimated as 8.15 × 10-2 and 0.21 mmol/g/h, respectively (at the initial concentration of 10 mg/L), while their quantum yield values were 1.56 × 10-6 and 3.83 × 10-6 molecules per photon, respectively.
32234599	6	69	theme	kinetic	1048:1054	arg1	0.21 mmol/g/h					1096:1108	0.21 mmol/g/h	1096:1108	0.21 mmol/g/h	1096:1108	Their reaction kinetic rates were estimated as 8.15 × 10-2 and 0.21 mmol/g/h, respectively (at the initial concentration of 10 mg/L), while their quantum yield values were 1.56 × 10-6 and 3.83 × 10-6 molecules per photon, respectively.
32234599	6	69	theme	kinetic	1048:1054	arg1	8.15 × 10-2					1080:1090	8.15 × 10-2	1080:1090	8.15 × 10-2	1080:1090	Their reaction kinetic rates were estimated as 8.15 × 10-2 and 0.21 mmol/g/h, respectively (at the initial concentration of 10 mg/L), while their quantum yield values were 1.56 × 10-6 and 3.83 × 10-6 molecules per photon, respectively.
32234599	8	70	theme	biomass	1542:1548	arg1	materials					1571:1579	biomass derived carbonaceous materials	1542:1579	biomass derived carbonaceous materials	1542:1579	The strategies used in this study offer a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water.
32234599	6	71	theme	initial	1132:1138	arg1	concentration					1140:1152	the initial concentration	1128:1152	the initial concentration of 10 mg/L	1128:1163	Their reaction kinetic rates were estimated as 8.15 × 10-2 and 0.21 mmol/g/h, respectively (at the initial concentration of 10 mg/L), while their quantum yield values were 1.56 × 10-6 and 3.83 × 10-6 molecules per photon, respectively.
32234599	6	72	theme	reaction	1039:1046	arg1	rates					1056:1060	Their reaction kinetic rates	1033:1060	Their reaction kinetic rates	1033:1060	Their reaction kinetic rates were estimated as 8.15 × 10-2 and 0.21 mmol/g/h, respectively (at the initial concentration of 10 mg/L), while their quantum yield values were 1.56 × 10-6 and 3.83 × 10-6 molecules per photon, respectively.
32234599	6	72	theme	reaction	1039:1046	arg1	0.21 mmol/g/h					1096:1108	0.21 mmol/g/h	1096:1108	0.21 mmol/g/h	1096:1108	Their reaction kinetic rates were estimated as 8.15 × 10-2 and 0.21 mmol/g/h, respectively (at the initial concentration of 10 mg/L), while their quantum yield values were 1.56 × 10-6 and 3.83 × 10-6 molecules per photon, respectively.
32234599	6	72	theme	reaction	1039:1046	arg1	8.15 × 10-2					1080:1090	8.15 × 10-2	1080:1090	8.15 × 10-2	1080:1090	Their reaction kinetic rates were estimated as 8.15 × 10-2 and 0.21 mmol/g/h, respectively (at the initial concentration of 10 mg/L), while their quantum yield values were 1.56 × 10-6 and 3.83 × 10-6 molecules per photon, respectively.
32234599	8	73	theme	contaminants	1625:1636	arg1	removal					1599:1605	the efficient removal	1585:1605	the efficient removal of multicomponent contaminants in water	1585:1645	The strategies used in this study offer a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water.
32234599	1	74	theme	biomass	218:224	arg1	nanofibers					251:260	biomass cellulose-derived carbon nanofibers	218:260	biomass cellulose-derived carbon nanofibers (CCNF)	218:267	A series of biomass cellulose-derived carbon nanofibers (CCNF) were prepared at different pyrolysis temperatures in this study.
32234599	1	74	theme	biomass	218:224	arg1	CCNF					263:266	CCNF	263:266	CCNF	263:266	A series of biomass cellulose-derived carbon nanofibers (CCNF) were prepared at different pyrolysis temperatures in this study.
32234599	3	75	theme	hexavalent	579:588	arg1	Cr					600:601	Cr(VI)	600:605	Cr(VI)	600:605	The feasibility of BiOBr/CCNF as photocatalyst was investigated for the treatment against organic dye, rhodamine B (RhB) and inorganic metal ion, hexavalent chromium (Cr(VI)).
32234599	3	75	theme	hexavalent	579:588	arg1	chromium					590:597	hexavalent chromium	579:597	hexavalent chromium (Cr(VI))	579:606	The feasibility of BiOBr/CCNF as photocatalyst was investigated for the treatment against organic dye, rhodamine B (RhB) and inorganic metal ion, hexavalent chromium (Cr(VI)).
32234599	3	75	theme	hexavalent	579:588	arg1	dye					531:533	organic dye	523:533	organic dye	523:533	The feasibility of BiOBr/CCNF as photocatalyst was investigated for the treatment against organic dye, rhodamine B (RhB) and inorganic metal ion, hexavalent chromium (Cr(VI)).
32234599	8	76	theme	derived	1550:1556	arg1	materials					1571:1579	biomass derived carbonaceous materials	1542:1579	biomass derived carbonaceous materials	1542:1579	The strategies used in this study offer a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water.
32234599	8	77	theme	carbonaceous	1558:1569	arg1	materials					1571:1579	biomass derived carbonaceous materials	1542:1579	biomass derived carbonaceous materials	1542:1579	The strategies used in this study offer a new pathway for preparing cost-effective photocatalysts with biomass derived carbonaceous materials for the efficient removal of multicomponent contaminants in water.
32234599	1	78	theme	cellulose-derived	226:242	arg1	nanofibers					251:260	biomass cellulose-derived carbon nanofibers	218:260	biomass cellulose-derived carbon nanofibers (CCNF)	218:267	A series of biomass cellulose-derived carbon nanofibers (CCNF) were prepared at different pyrolysis temperatures in this study.
32234599	1	78	theme	cellulose-derived	226:242	arg1	CCNF					263:266	CCNF	263:266	CCNF	263:266	A series of biomass cellulose-derived carbon nanofibers (CCNF) were prepared at different pyrolysis temperatures in this study.
32338465	0	0	theme	Inflammation	96:107	arg1	Microenvironment					109:124	Inflammation Microenvironment	96:124	Inflammation Microenvironment	96:124	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing.
32338465	4	1	theme	hyaluronic	574:583	arg1	FHHA-S/Fe					602:610	FHHA-S/Fe	602:610	FHHA-S/Fe	602:610	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	4	1	theme	hyaluronic	574:583	arg1	able					617:620	able	617:620	able	617:620	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	4	1	theme	hyaluronic	574:583	arg1	nanofibers					590:599	The electrospun thioether grafted hyaluronic acid nanofibers	540:599	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe)	540:611	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	8	2	theme	average	1173:1179	arg1	area					1197:1200	the average remaining wound area	1169:1200	the average remaining wound area after FHHA-S/Fe treatment	1169:1226	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	8	2	theme	average	1173:1179	arg1	smaller					1236:1242	smaller	1236:1242	smaller	1236:1242	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	9	3	theme	microenvironment	1474:1489	arg1	mechanisms					1437:1446	intrinsic dual modulation mechanisms	1411:1446	intrinsic dual modulation mechanisms of the wound inflammation microenvironment	1411:1489	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	8	4	theme	chronic	1139:1145	arg1	model					1162:1166	the chronic diabetic wound model	1135:1166	the chronic diabetic wound model	1135:1166	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	6	5	theme	inflammation	869:880	arg1	reactions					882:890	the inflammation reactions	865:890	the inflammation reactions	865:890	The grafted thioethers on HHA can scavenge the reactive oxygen species quickly in the early inflammation phase to relieve the inflammation reactions.
32338465	1	6	theme	care	192:195	arg1	dressings					197:205	care dressings	192:205	care dressings	192:205	Current standard of care dressings are unsatisfactorily inefficacious for the treatment of chronic wounds.
32338465	3	7	theme	nanofibrous	396:406	arg1	hydrogel					408:415	an absorbable nanofibrous hydrogel	382:415	an absorbable nanofibrous hydrogel	382:415	Herein, an absorbable nanofibrous hydrogel is developed for synergistic modulation of the inflammation microenvironment to accelerate chronic diabetic wound healing.
32338465	8	8	theme	grafted	1278:1284	arg1	thioethers					1286:1295	grafted thioethers	1278:1295	grafted thioethers	1278:1295	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	2	9	theme	long-term	328:336	arg1	nature					348:353	the long-term incurable nature	324:353	the long-term incurable nature of chronic wounds	324:371	Chronic inflammation is the primary cause of the long-term incurable nature of chronic wounds.
32338465	0	10	theme	Microenvironment	109:124	arg1	Modulation					82:91	Synergistic Modulation	70:91	Synergistic Modulation of Inflammation Microenvironment	70:124	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing.
32338465	4	11	theme	electrospun	544:554	arg1	FHHA-S/Fe					602:610	FHHA-S/Fe	602:610	FHHA-S/Fe	602:610	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	4	11	theme	electrospun	544:554	arg1	able					617:620	able	617:620	able	617:620	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	4	11	theme	electrospun	544:554	arg1	nanofibers					590:599	The electrospun thioether grafted hyaluronic acid nanofibers	540:599	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe)	540:611	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	7	12	theme	M2	998:999	arg1	phenotype					1001:1009	the M2 phenotype	994:1009	the M2 phenotype	994:1009	Additionally, the HHA itself is able to promote the transformation of the gathered M1 macrophages to the M2 phenotype, thus synergistically accelerating the wound healing phase transition from inflammation to proliferation and remodeling.
32338465	8	13	theme	healing	1350:1356	arg1	stage					1358:1362	the early wound healing stage	1334:1362	the early wound healing stage	1334:1362	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	0	14	theme	Chronic	140:146	arg1	Healing					163:169	Chronic Diabetic Wound Healing	140:169	Chronic Diabetic Wound Healing	140:169	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing.
32338465	9	15	theme	wound	1555:1559	arg1	management					1561:1570	chronic wound management	1547:1570	chronic wound management	1547:1570	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	1	16	theme	dressings	197:205	arg1	standard					180:187	standard	180:187	standard	180:187	Current standard of care dressings are unsatisfactorily inefficacious for the treatment of chronic wounds.
32338465	3	17	theme	absorbable	385:394	arg1	hydrogel					408:415	an absorbable nanofibrous hydrogel	382:415	an absorbable nanofibrous hydrogel	382:415	Herein, an absorbable nanofibrous hydrogel is developed for synergistic modulation of the inflammation microenvironment to accelerate chronic diabetic wound healing.
32338465	4	18	theme	grafted	566:572	arg1	FHHA-S/Fe					602:610	FHHA-S/Fe	602:610	FHHA-S/Fe	602:610	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	4	18	theme	grafted	566:572	arg1	able					617:620	able	617:620	able	617:620	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	4	18	theme	grafted	566:572	arg1	nanofibers					590:599	The electrospun thioether grafted hyaluronic acid nanofibers	540:599	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe)	540:611	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	9	19	with	strategy	1397:1404	arg1	mechanisms					1437:1446	intrinsic dual modulation mechanisms	1411:1446	intrinsic dual modulation mechanisms of the wound inflammation microenvironment	1411:1489	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	3	20	theme	synergistic	434:444	arg1	modulation					446:455	synergistic modulation	434:455	synergistic modulation of the inflammation microenvironment to accelerate chronic diabetic wound healing	434:537	Herein, an absorbable nanofibrous hydrogel is developed for synergistic modulation of the inflammation microenvironment to accelerate chronic diabetic wound healing.
32338465	3	21	theme	chronic	508:514	arg1	healing					531:537	chronic diabetic wound healing	508:537	chronic diabetic wound healing	508:537	Herein, an absorbable nanofibrous hydrogel is developed for synergistic modulation of the inflammation microenvironment to accelerate chronic diabetic wound healing.
32338465	0	22	theme	Thioether	11:19	arg1	Hydrogel					57:64	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel	0:64	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment	0:124	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing.
32338465	4	23	theme	thioether	556:564	arg1	FHHA-S/Fe					602:610	FHHA-S/Fe	602:610	FHHA-S/Fe	602:610	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	4	23	theme	thioether	556:564	arg1	able					617:620	able	617:620	able	617:620	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	4	23	theme	thioether	556:564	arg1	nanofibers					590:599	The electrospun thioether grafted hyaluronic acid nanofibers	540:599	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe)	540:611	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	6	24	theme	inflammation	835:846	arg1	phase					848:852	the early inflammation phase	825:852	the early inflammation phase	825:852	The grafted thioethers on HHA can scavenge the reactive oxygen species quickly in the early inflammation phase to relieve the inflammation reactions.
32338465	2	25	theme	chronic	358:364	arg1	wounds					366:371	chronic wounds	358:371	chronic wounds	358:371	Chronic inflammation is the primary cause of the long-term incurable nature of chronic wounds.
32338465	6	26	theme	grafted	747:753	arg1	thioethers					755:764	The grafted thioethers	743:764	The grafted thioethers on HHA	743:771	The grafted thioethers on HHA can scavenge the reactive oxygen species quickly in the early inflammation phase to relieve the inflammation reactions.
32338465	3	27	theme	microenvironment	477:492	arg1	modulation					446:455	synergistic modulation	434:455	synergistic modulation of the inflammation microenvironment to accelerate chronic diabetic wound healing	434:537	Herein, an absorbable nanofibrous hydrogel is developed for synergistic modulation of the inflammation microenvironment to accelerate chronic diabetic wound healing.
32338465	0	28	theme	Absorbable	0:9	arg1	Hydrogel					57:64	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel	0:64	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment	0:124	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing.
32338465	9	29	theme	facile	1381:1386	arg1	strategy					1397:1404	this facile dressing strategy	1376:1404	this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment	1376:1489	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	9	29	theme	facile	1381:1386	arg1	strategy					1534:1541	an effective and safe treatment strategy	1502:1541	an effective and safe treatment strategy for chronic wound management	1502:1570	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	6	30	theme	early	829:833	arg1	phase					848:852	the early inflammation phase	825:852	the early inflammation phase	825:852	The grafted thioethers on HHA can scavenge the reactive oxygen species quickly in the early inflammation phase to relieve the inflammation reactions.
32338465	8	31	theme	FHHA-S/Fe	1208:1216	arg1	treatment					1218:1226	FHHA-S/Fe treatment	1208:1226	FHHA-S/Fe treatment	1208:1226	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	8	32	theme	control	1305:1311	arg1	group					1313:1317	the control group	1301:1317	the control group	1301:1317	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	0	33	theme	Hyaluronic	29:38	arg1	Hydrogel					57:64	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel	0:64	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment	0:124	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing.
32338465	7	34	theme	M1	976:977	arg1	macrophages					979:989	the gathered M1 macrophages	963:989	the gathered M1 macrophages	963:989	Additionally, the HHA itself is able to promote the transformation of the gathered M1 macrophages to the M2 phenotype, thus synergistically accelerating the wound healing phase transition from inflammation to proliferation and remodeling.
32338465	0	35	theme	Wound	157:161	arg1	Healing					163:169	Chronic Diabetic Wound Healing	140:169	Chronic Diabetic Wound Healing	140:169	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing.
32338465	7	36	theme	macrophages	979:989	arg1	transformation					945:958	the transformation	941:958	the transformation of the gathered M1 macrophages to the M2 phenotype	941:1009	Additionally, the HHA itself is able to promote the transformation of the gathered M1 macrophages to the M2 phenotype, thus synergistically accelerating the wound healing phase transition from inflammation to proliferation and remodeling.
32338465	2	37	theme	nature	348:353	arg1	cause					315:319	the primary cause	303:319	the primary cause of the long-term incurable nature of chronic wounds	303:371	Chronic inflammation is the primary cause of the long-term incurable nature of chronic wounds.
32338465	2	37	theme	nature	348:353	arg1	inflammation					287:298	Chronic inflammation	279:298	Chronic inflammation	279:298	Chronic inflammation is the primary cause of the long-term incurable nature of chronic wounds.
32338465	9	38	theme	treatment	1524:1532	arg1	strategy					1397:1404	this facile dressing strategy	1376:1404	this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment	1376:1489	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	9	38	theme	treatment	1524:1532	arg1	strategy					1534:1541	an effective and safe treatment strategy	1502:1541	an effective and safe treatment strategy for chronic wound management	1502:1570	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	0	39	theme	Grafted	21:27	arg1	Hydrogel					57:64	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel	0:64	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment	0:124	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing.
32338465	4	40	theme	nanofibrous	632:642	arg1	hydrogel					644:651	a nanofibrous hydrogel	630:651	a nanofibrous hydrogel	630:651	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	0	41	theme	Diabetic	148:155	arg1	Healing					163:169	Chronic Diabetic Wound Healing	140:169	Chronic Diabetic Wound Healing	140:169	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing.
32338465	2	42	theme	incurable	338:346	arg1	nature					348:353	the long-term incurable nature	324:353	the long-term incurable nature of chronic wounds	324:371	Chronic inflammation is the primary cause of the long-term incurable nature of chronic wounds.
32338465	0	43	theme	Nanofibrous	45:55	arg1	Hydrogel					57:64	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel	0:64	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment	0:124	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing.
32338465	9	44	theme	wound	1455:1459	arg1	microenvironment					1474:1489	the wound inflammation microenvironment	1451:1489	the wound inflammation microenvironment	1451:1489	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	2	45	theme	Chronic	279:285	arg1	cause					315:319	the primary cause	303:319	the primary cause of the long-term incurable nature of chronic wounds	303:371	Chronic inflammation is the primary cause of the long-term incurable nature of chronic wounds.
32338465	2	45	theme	Chronic	279:285	arg1	inflammation					287:298	Chronic inflammation	279:298	Chronic inflammation	279:298	Chronic inflammation is the primary cause of the long-term incurable nature of chronic wounds.
32338465	9	46	theme	safe	1519:1522	arg1	strategy					1397:1404	this facile dressing strategy	1376:1404	this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment	1376:1489	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	9	46	theme	safe	1519:1522	arg1	strategy					1534:1541	an effective and safe treatment strategy	1502:1541	an effective and safe treatment strategy for chronic wound management	1502:1570	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	3	47	theme	diabetic	516:523	arg1	healing					531:537	chronic diabetic wound healing	508:537	chronic diabetic wound healing	508:537	Herein, an absorbable nanofibrous hydrogel is developed for synergistic modulation of the inflammation microenvironment to accelerate chronic diabetic wound healing.
32338465	0	48	theme	Acid	40:43	arg1	Hydrogel					57:64	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel	0:64	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment	0:124	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing.
32338465	9	49	theme	intrinsic	1411:1419	arg1	mechanisms					1437:1446	intrinsic dual modulation mechanisms	1411:1446	intrinsic dual modulation mechanisms of the wound inflammation microenvironment	1411:1489	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	3	50	theme	inflammation	464:475	arg1	microenvironment					477:492	the inflammation microenvironment	460:492	the inflammation microenvironment	460:492	Herein, an absorbable nanofibrous hydrogel is developed for synergistic modulation of the inflammation microenvironment to accelerate chronic diabetic wound healing.
32338465	9	51	theme	dressing	1388:1395	arg1	strategy					1397:1404	this facile dressing strategy	1376:1404	this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment	1376:1489	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	9	51	theme	dressing	1388:1395	arg1	strategy					1534:1541	an effective and safe treatment strategy	1502:1541	an effective and safe treatment strategy for chronic wound management	1502:1570	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	3	52	theme	wound	525:529	arg1	healing					531:537	chronic diabetic wound healing	508:537	chronic diabetic wound healing	508:537	Herein, an absorbable nanofibrous hydrogel is developed for synergistic modulation of the inflammation microenvironment to accelerate chronic diabetic wound healing.
32338465	9	53	theme	dual	1421:1424	arg1	mechanisms					1437:1446	intrinsic dual modulation mechanisms	1411:1446	intrinsic dual modulation mechanisms of the wound inflammation microenvironment	1411:1489	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	8	54	theme	wound	1191:1195	arg1	area					1197:1200	the average remaining wound area	1169:1200	the average remaining wound area after FHHA-S/Fe treatment	1169:1226	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	8	54	theme	wound	1191:1195	arg1	smaller					1236:1242	smaller	1236:1242	smaller	1236:1242	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	8	55	theme	wound	1344:1348	arg1	stage					1358:1362	the early wound healing stage	1334:1362	the early wound healing stage	1334:1362	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	8	56	theme	wound	1156:1160	arg1	model					1162:1166	the chronic diabetic wound model	1135:1166	the chronic diabetic wound model	1135:1166	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	9	57	theme	modulation	1426:1435	arg1	mechanisms					1437:1446	intrinsic dual modulation mechanisms	1411:1446	intrinsic dual modulation mechanisms of the wound inflammation microenvironment	1411:1489	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	8	58	theme	diabetic	1147:1154	arg1	model					1162:1166	the chronic diabetic wound model	1135:1166	the chronic diabetic wound model	1135:1166	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	7	59	theme	healing	1056:1062	arg1	transition					1070:1079	the wound healing phase transition	1046:1079	the wound healing phase transition from inflammation to proliferation and remodeling	1046:1129	Additionally, the HHA itself is able to promote the transformation of the gathered M1 macrophages to the M2 phenotype, thus synergistically accelerating the wound healing phase transition from inflammation to proliferation and remodeling.
32338465	8	60	theme	early	1338:1342	arg1	stage					1358:1362	the early wound healing stage	1334:1362	the early wound healing stage	1334:1362	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	8	61	theme	remaining	1181:1189	arg1	area					1197:1200	the average remaining wound area	1169:1200	the average remaining wound area after FHHA-S/Fe treatment	1169:1226	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	8	61	theme	remaining	1181:1189	arg1	smaller					1236:1242	smaller	1236:1242	smaller	1236:1242	On the chronic diabetic wound model, the average remaining wound area after FHHA-S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage.
32338465	2	62	theme	primary	307:313	arg1	cause					315:319	the primary cause	303:319	the primary cause of the long-term incurable nature of chronic wounds	303:371	Chronic inflammation is the primary cause of the long-term incurable nature of chronic wounds.
32338465	2	62	theme	primary	307:313	arg1	inflammation					287:298	Chronic inflammation	279:298	Chronic inflammation	279:298	Chronic inflammation is the primary cause of the long-term incurable nature of chronic wounds.
32338465	6	63	theme	oxygen	799:804	arg1	species					806:812	the reactive oxygen species	786:812	the reactive oxygen species	786:812	The grafted thioethers on HHA can scavenge the reactive oxygen species quickly in the early inflammation phase to relieve the inflammation reactions.
32338465	7	64	theme	gathered	967:974	arg1	macrophages					979:989	the gathered M1 macrophages	963:989	the gathered M1 macrophages	963:989	Additionally, the HHA itself is able to promote the transformation of the gathered M1 macrophages to the M2 phenotype, thus synergistically accelerating the wound healing phase transition from inflammation to proliferation and remodeling.
32338465	1	65	theme	chronic	263:269	arg1	wounds					271:276	chronic wounds	263:276	chronic wounds	263:276	Current standard of care dressings are unsatisfactorily inefficacious for the treatment of chronic wounds.
32338465	7	66	theme	phase	1064:1068	arg1	transition					1070:1079	the wound healing phase transition	1046:1079	the wound healing phase transition from inflammation to proliferation and remodeling	1046:1129	Additionally, the HHA itself is able to promote the transformation of the gathered M1 macrophages to the M2 phenotype, thus synergistically accelerating the wound healing phase transition from inflammation to proliferation and remodeling.
32338465	6	67	from	thioethers	755:764	arg1	HHA					769:771	HHA	769:771	HHA	769:771	The grafted thioethers on HHA can scavenge the reactive oxygen species quickly in the early inflammation phase to relieve the inflammation reactions.
32338465	6	68	theme	reactive	790:797	arg1	species					806:812	the reactive oxygen species	786:812	the reactive oxygen species	786:812	The grafted thioethers on HHA can scavenge the reactive oxygen species quickly in the early inflammation phase to relieve the inflammation reactions.
32338465	2	69	theme	wounds	366:371	arg1	nature					348:353	the long-term incurable nature	324:353	the long-term incurable nature of chronic wounds	324:371	Chronic inflammation is the primary cause of the long-term incurable nature of chronic wounds.
32338465	1	70	theme	wounds	271:276	arg1	treatment					250:258	the treatment	246:258	the treatment of chronic wounds	246:276	Current standard of care dressings are unsatisfactorily inefficacious for the treatment of chronic wounds.
32338465	9	71	theme	chronic	1547:1553	arg1	management					1561:1570	chronic wound management	1547:1570	chronic wound management	1547:1570	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	7	72	theme	wound	1050:1054	arg1	healing					1056:1062	wound healing	1050:1062	the wound healing phase transition from inflammation to proliferation and remodeling	1046:1129	Additionally, the HHA itself is able to promote the transformation of the gathered M1 macrophages to the M2 phenotype, thus synergistically accelerating the wound healing phase transition from inflammation to proliferation and remodeling.
32338465	9	73	theme	effective	1505:1513	arg1	strategy					1397:1404	this facile dressing strategy	1376:1404	this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment	1376:1489	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	9	73	theme	effective	1505:1513	arg1	strategy					1534:1541	an effective and safe treatment strategy	1502:1541	an effective and safe treatment strategy for chronic wound management	1502:1570	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32338465	7	74	from	inflammation	1086:1097	arg1	transition					1070:1079	the wound healing phase transition	1046:1079	the wound healing phase transition from inflammation to proliferation and remodeling	1046:1129	Additionally, the HHA itself is able to promote the transformation of the gathered M1 macrophages to the M2 phenotype, thus synergistically accelerating the wound healing phase transition from inflammation to proliferation and remodeling.
32338465	0	75	theme	Synergistic	70:80	arg1	Modulation					82:91	Synergistic Modulation	70:91	Synergistic Modulation of Inflammation Microenvironment	70:124	Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing.
32338465	4	76	theme	acid	585:588	arg1	FHHA-S/Fe					602:610	FHHA-S/Fe	602:610	FHHA-S/Fe	602:610	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	4	76	theme	acid	585:588	arg1	able					617:620	able	617:620	able	617:620	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	4	76	theme	acid	585:588	arg1	nanofibers					590:599	The electrospun thioether grafted hyaluronic acid nanofibers	540:599	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe)	540:611	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	4	77	theme	wound	668:672	arg1	bed					674:676	the wound bed	664:676	the wound bed	664:676	The electrospun thioether grafted hyaluronic acid nanofibers (FHHA-S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed.
32338465	9	78	theme	inflammation	1461:1472	arg1	microenvironment					1474:1489	the wound inflammation microenvironment	1451:1489	the wound inflammation microenvironment	1451:1489	Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.
32211690	8	0	theme	appropriate	1102:1112	arg1	method					1128:1133	the appropriate normalization method	1098:1133	the appropriate normalization method applied to glycomics data	1098:1159	Until now, there is no clear consensus on the appropriate normalization method applied to glycomics data.
32211690	13	1	theme	sample-wise	1737:1747	arg1	differences					1749:1759	sample-wise differences	1737:1759	sample-wise differences	1737:1759	We show that when sample-wise differences are not large row-wise normalization (like TA) can have deleterious effects on variable selection and prediction.
32211690	12	2	theme	additive	1669:1676	arg1	glycans					1660:1666	glycans	1660:1666	glycans: additive, multiplicative	1660:1692	We also address the effect of various types of measurement error in glycans: additive, multiplicative and two-component error.
32211690	6	3	dep	lead	881:884	arg1	Ignoring					820:827	Ignoring	820:827	Ignoring the compositional nature of the data	820:864	Ignoring the compositional nature of the data, moreover, may lead to spurious results.
32211690	0	4	theme	biomarkers	74:83	arg1	discovery					47:55	discovery	47:55	discovery of sparse glycan biomarkers	47:83	Choosing proper normalization is essential for discovery of sparse glycan biomarkers.
32211690	9	5	theme	TA	1268:1269	arg1	choice					1258:1263	the choice	1254:1263	the choice of TA	1254:1269	Nor is systematic investigation of impact of TA on downstream analysis available to justify the choice of TA.
32211690	10	6	theme	model	1424:1428	arg1	prediction					1378:1387	accurate prediction	1369:1387	accurate prediction as well as interpretability of the model chosen	1369:1435	Our motivation lies in efficient variable selection to identify glycan biomarkers with regard to accurate prediction as well as interpretability of the model chosen.
32211690	10	6	theme	model	1424:1428	arg1	interpretability					1400:1415	interpretability	1400:1415	accurate prediction as well as interpretability of the model chosen	1369:1435	Our motivation lies in efficient variable selection to identify glycan biomarkers with regard to accurate prediction as well as interpretability of the model chosen.
32211690	11	7	theme	variable	1541:1548	arg1	selection					1550:1558	variable selection	1541:1558	variable selection	1541:1558	Via extensive simulations we investigate how different normalization methods affect the performance of variable selection, and compare their performance.
32211690	1	8	theme	large	174:178	arg1	studies					187:193	large sample studies	174:193	large sample studies	174:193	Rapid progress in high-throughput glycomics analysis enables the researchers to conduct large sample studies.
32211690	11	9	theme	normalization	1493:1505	arg1	methods					1507:1513	different normalization methods	1483:1513	different normalization methods	1483:1513	Via extensive simulations we investigate how different normalization methods affect the performance of variable selection, and compare their performance.
32211690	8	10	from	consensus	1085:1093	arg1	method					1128:1133	the appropriate normalization method	1098:1133	the appropriate normalization method applied to glycomics data	1098:1159	Until now, there is no clear consensus on the appropriate normalization method applied to glycomics data.
32211690	13	11	theme	row-wise	1775:1782	arg1	normalization					1784:1796	row-wise normalization	1775:1796	row-wise normalization (like TA)	1775:1806	We show that when sample-wise differences are not large row-wise normalization (like TA) can have deleterious effects on variable selection and prediction.
32211690	3	12	dep	Essentially	390:400	arg1	there					402:406	there	402:406	there	402:406	Essentially there are two ways to approach this issue: row-wise and column-wise normalization.
32211690	10	13	theme	accurate	1369:1376	arg1	prediction					1378:1387	accurate prediction	1369:1387	accurate prediction as well as interpretability of the model chosen	1369:1435	Our motivation lies in efficient variable selection to identify glycan biomarkers with regard to accurate prediction as well as interpretability of the model chosen.
32211690	9	14	from	analysis	1224:1231	arg1	investigation					1180:1192	systematic investigation	1169:1192	systematic investigation of impact of TA on downstream analysis available to justify the choice of TA	1169:1269	Nor is systematic investigation of impact of TA on downstream analysis available to justify the choice of TA.
32211690	13	15	theme	deleterious	1817:1827	arg1	effects					1829:1835	deleterious effects	1817:1835	deleterious effects	1817:1835	We show that when sample-wise differences are not large row-wise normalization (like TA) can have deleterious effects on variable selection and prediction.
32211690	12	16	from	glycans	1660:1666	arg1	types					1630:1634	various types	1622:1634	various types of measurement error in glycans: additive, multiplicative and two-component error	1622:1716	We also address the effect of various types of measurement error in glycans: additive, multiplicative and two-component error.
32211690	2	17	from	differences	227:237	arg1	abundance					248:256	total abundance	242:256	total abundance of raw glycomics data	242:278	Typically, the between-subject differences in total abundance of raw glycomics data are very large, and it is necessary to reduce the differences, making measurements comparable across samples.
32211690	9	18	from	impact	1197:1202	arg1	analysis					1224:1231	downstream analysis	1213:1231	downstream analysis available to justify the choice of TA	1213:1269	Nor is systematic investigation of impact of TA on downstream analysis available to justify the choice of TA.
32211690	5	19	theme	statistical	769:779	arg1	methods					781:787	many standard multivariate statistical methods	742:787	many standard multivariate statistical methods	742:787	This total area (row-wise) normalization (TA) results in so-called compositional data, rendering many standard multivariate statistical methods inappropriate or inapplicable.
32211690	12	20	theme	error	1651:1655	arg1	types					1630:1634	various types	1622:1634	various types of measurement error in glycans: additive, multiplicative and two-component error	1622:1716	We also address the effect of various types of measurement error in glycans: additive, multiplicative and two-component error.
32211690	1	21	theme	sample	180:185	arg1	studies					187:193	large sample studies	174:193	large sample studies	174:193	Rapid progress in high-throughput glycomics analysis enables the researchers to conduct large sample studies.
32211690	8	22	theme	glycomics	1146:1154	arg1	data					1156:1159	glycomics data	1146:1159	glycomics data	1146:1159	Until now, there is no clear consensus on the appropriate normalization method applied to glycomics data.
32211690	6	23	theme	compositional	833:845	arg1	nature					847:852	the compositional nature	829:852	the compositional nature of the data	829:864	Ignoring the compositional nature of the data, moreover, may lead to spurious results.
32211690	12	24	from	error	1651:1655	arg1	glycans					1660:1666	glycans	1660:1666	glycans: additive, multiplicative	1660:1692	We also address the effect of various types of measurement error in glycans: additive, multiplicative and two-component error.
32211690	12	25	dep	additive	1669:1676	arg1	multiplicative					1679:1692	multiplicative	1679:1692	multiplicative	1679:1692	We also address the effect of various types of measurement error in glycans: additive, multiplicative and two-component error.
32211690	0	26	theme	proper	9:14	arg1	normalization					16:28	Choosing proper normalization	0:28	Choosing proper normalization	0:28	Choosing proper normalization is essential for discovery of sparse glycan biomarkers.
32211690	6	27	theme	data	861:864	arg1	nature					847:852	the compositional nature	829:852	the compositional nature of the data	829:864	Ignoring the compositional nature of the data, moreover, may lead to spurious results.
32211690	3	28	dep	ways	416:419	arg1	ways					416:419	two ways	412:419	two ways to approach this issue: row-wise and column-wise normalization	412:482	Essentially there are two ways to approach this issue: row-wise and column-wise normalization.
32211690	3	28	dep	ways	416:419	arg1	row-wise					445:452	row-wise	445:452	row-wise	445:452	Essentially there are two ways to approach this issue: row-wise and column-wise normalization.
32211690	3	28	dep	ways	416:419	arg1	normalization					470:482	column-wise normalization	458:482	column-wise normalization	458:482	Essentially there are two ways to approach this issue: row-wise and column-wise normalization.
32211690	5	29	theme	so-called	702:710	arg1	data					726:729	so-called compositional data	702:729	so-called compositional data	702:729	This total area (row-wise) normalization (TA) results in so-called compositional data, rendering many standard multivariate statistical methods inappropriate or inapplicable.
32211690	1	30	theme	Rapid	86:90	arg1	progress					92:99	Rapid progress	86:99	Rapid progress in high-throughput glycomics analysis	86:137	Rapid progress in high-throughput glycomics analysis enables the researchers to conduct large sample studies.
32211690	7	31	theme	standard	1028:1035	arg1	tools					1049:1053	standard statistical tools	1028:1053	standard statistical tools	1028:1053	Alternatively, a log-transformation to the raw data can be performed prior to column-wise normalization and implementing standard statistical tools.
32211690	0	32	theme	Choosing	0:7	arg1	normalization					16:28	Choosing proper normalization	0:28	Choosing proper normalization	0:28	Choosing proper normalization is essential for discovery of sparse glycan biomarkers.
32211690	9	33	theme	impact	1197:1202	arg1	investigation					1180:1192	systematic investigation	1169:1192	systematic investigation of impact of TA on downstream analysis available to justify the choice of TA	1169:1269	Nor is systematic investigation of impact of TA on downstream analysis available to justify the choice of TA.
32211690	11	34	theme	extensive	1442:1450	arg1	simulations					1452:1462	extensive simulations	1442:1462	extensive simulations	1442:1462	Via extensive simulations we investigate how different normalization methods affect the performance of variable selection, and compare their performance.
32211690	2	35	theme	glycomics	265:273	arg1	data					275:278	raw glycomics data	261:278	raw glycomics data	261:278	Typically, the between-subject differences in total abundance of raw glycomics data are very large, and it is necessary to reduce the differences, making measurements comparable across samples.
32211690	5	36	theme	row-wise	662:669	arg1	TA					687:688	TA	687:688	TA	687:688	This total area (row-wise) normalization (TA) results in so-called compositional data, rendering many standard multivariate statistical methods inappropriate or inapplicable.
32211690	5	36	theme	row-wise	662:669	arg1	normalization					672:684	This total area (row-wise) normalization	645:684	This total area (row-wise) normalization (TA)	645:689	This total area (row-wise) normalization (TA) results in so-called compositional data, rendering many standard multivariate statistical methods inappropriate or inapplicable.
32211690	9	37	theme	systematic	1169:1178	arg1	investigation					1180:1192	systematic investigation	1169:1192	systematic investigation of impact of TA on downstream analysis available to justify the choice of TA	1169:1269	Nor is systematic investigation of impact of TA on downstream analysis available to justify the choice of TA.
32211690	12	38	from	types	1630:1634	arg1	glycans					1660:1666	glycans	1660:1666	glycans: additive, multiplicative	1660:1692	We also address the effect of various types of measurement error in glycans: additive, multiplicative and two-component error.
32211690	12	39	theme	various	1622:1628	arg1	types					1630:1634	various types	1622:1634	various types of measurement error in glycans: additive, multiplicative and two-component error	1622:1716	We also address the effect of various types of measurement error in glycans: additive, multiplicative and two-component error.
32211690	3	40	theme	column-wise	458:468	arg1	ways					416:419	two ways	412:419	two ways to approach this issue: row-wise and column-wise normalization	412:482	Essentially there are two ways to approach this issue: row-wise and column-wise normalization.
32211690	3	40	theme	column-wise	458:468	arg1	normalization					470:482	column-wise normalization	458:482	column-wise normalization	458:482	Essentially there are two ways to approach this issue: row-wise and column-wise normalization.
32211690	11	41	theme	different	1483:1491	arg1	methods					1507:1513	different normalization methods	1483:1513	different normalization methods	1483:1513	Via extensive simulations we investigate how different normalization methods affect the performance of variable selection, and compare their performance.
32211690	9	42	theme	TA	1207:1208	arg1	impact					1197:1202	impact	1197:1202	impact of TA on downstream analysis available to justify the choice of TA	1197:1269	Nor is systematic investigation of impact of TA on downstream analysis available to justify the choice of TA.
32211690	1	43	theme	high-throughput	104:118	arg1	analysis					130:137	high-throughput glycomics analysis	104:137	high-throughput glycomics analysis	104:137	Rapid progress in high-throughput glycomics analysis enables the researchers to conduct large sample studies.
32211690	12	44	theme	measurement	1639:1649	arg1	error					1651:1655	measurement error	1639:1655	measurement error in glycans: additive, multiplicative	1639:1692	We also address the effect of various types of measurement error in glycans: additive, multiplicative and two-component error.
32211690	12	45	theme	types	1630:1634	arg1	effect					1612:1617	the effect	1608:1617	the effect of various types of measurement error in glycans: additive, multiplicative and two-component error	1608:1716	We also address the effect of various types of measurement error in glycans: additive, multiplicative and two-component error.
32211690	7	46	theme	statistical	1037:1047	arg1	tools					1049:1053	standard statistical tools	1028:1053	standard statistical tools	1028:1053	Alternatively, a log-transformation to the raw data can be performed prior to column-wise normalization and implementing standard statistical tools.
32211690	13	47	contain	have	1812:1815	arg1	normalization					1784:1796	row-wise normalization	1775:1796	row-wise normalization (like TA)	1775:1806	We show that when sample-wise differences are not large row-wise normalization (like TA) can have deleterious effects on variable selection and prediction.
32211690	13	47	contain	have	1812:1815	arg2	effects					1829:1835	deleterious effects	1817:1835	deleterious effects	1817:1835	We show that when sample-wise differences are not large row-wise normalization (like TA) can have deleterious effects on variable selection and prediction.
32211690	13	48	theme	variable	1840:1847	arg1	selection					1849:1857	variable selection	1840:1857	variable selection	1840:1857	We show that when sample-wise differences are not large row-wise normalization (like TA) can have deleterious effects on variable selection and prediction.
32211690	4	49	theme	equal	630:634	arg1	intensities					618:628	all glycan intensities	607:628	all glycan intensities equal to 100%	607:642	In glycomics, the differences per subject are usually forced to be exactly zero, by scaling each sample having the sum of all glycan intensities equal to 100%.
32211690	5	50	theme	many	742:745	arg1	methods					781:787	many standard multivariate statistical methods	742:787	many standard multivariate statistical methods	742:787	This total area (row-wise) normalization (TA) results in so-called compositional data, rendering many standard multivariate statistical methods inappropriate or inapplicable.
32211690	8	51	theme	normalization	1114:1126	arg1	method					1128:1133	the appropriate normalization method	1098:1133	the appropriate normalization method applied to glycomics data	1098:1159	Until now, there is no clear consensus on the appropriate normalization method applied to glycomics data.
32211690	4	52	theme	intensities	618:628	arg1	sum					600:602	the sum	596:602	the sum of all glycan intensities equal to 100%	596:642	In glycomics, the differences per subject are usually forced to be exactly zero, by scaling each sample having the sum of all glycan intensities equal to 100%.
32211690	5	53	theme	standard	747:754	arg1	methods					781:787	many standard multivariate statistical methods	742:787	many standard multivariate statistical methods	742:787	This total area (row-wise) normalization (TA) results in so-called compositional data, rendering many standard multivariate statistical methods inappropriate or inapplicable.
32211690	8	54	theme	clear	1079:1083	arg1	consensus					1085:1093	no clear consensus	1076:1093	no clear consensus on the appropriate normalization method applied to glycomics data	1076:1159	Until now, there is no clear consensus on the appropriate normalization method applied to glycomics data.
32211690	5	55	theme	compositional	712:724	arg1	data					726:729	so-called compositional data	702:729	so-called compositional data	702:729	This total area (row-wise) normalization (TA) results in so-called compositional data, rendering many standard multivariate statistical methods inappropriate or inapplicable.
32211690	2	56	theme	total	242:246	arg1	abundance					248:256	total abundance	242:256	total abundance of raw glycomics data	242:278	Typically, the between-subject differences in total abundance of raw glycomics data are very large, and it is necessary to reduce the differences, making measurements comparable across samples.
32211690	7	57	theme	column-wise	985:995	arg1	normalization					997:1009	column-wise normalization	985:1009	column-wise normalization	985:1009	Alternatively, a log-transformation to the raw data can be performed prior to column-wise normalization and implementing standard statistical tools.
32211690	1	58	theme	glycomics	120:128	arg1	analysis					130:137	high-throughput glycomics analysis	104:137	high-throughput glycomics analysis	104:137	Rapid progress in high-throughput glycomics analysis enables the researchers to conduct large sample studies.
32211690	5	59	theme	multivariate	756:767	arg1	methods					781:787	many standard multivariate statistical methods	742:787	many standard multivariate statistical methods	742:787	This total area (row-wise) normalization (TA) results in so-called compositional data, rendering many standard multivariate statistical methods inappropriate or inapplicable.
32211690	5	60	theme	total	650:654	arg1	TA					687:688	TA	687:688	TA	687:688	This total area (row-wise) normalization (TA) results in so-called compositional data, rendering many standard multivariate statistical methods inappropriate or inapplicable.
32211690	5	60	theme	total	650:654	arg1	normalization					672:684	This total area (row-wise) normalization	645:684	This total area (row-wise) normalization (TA)	645:689	This total area (row-wise) normalization (TA) results in so-called compositional data, rendering many standard multivariate statistical methods inappropriate or inapplicable.
32211690	9	61	theme	available	1233:1241	arg1	analysis					1224:1231	downstream analysis	1213:1231	downstream analysis available to justify the choice of TA	1213:1269	Nor is systematic investigation of impact of TA on downstream analysis available to justify the choice of TA.
32211690	11	62	theme	selection	1550:1558	arg1	performance					1526:1536	the performance	1522:1536	the performance of variable selection	1522:1558	Via extensive simulations we investigate how different normalization methods affect the performance of variable selection, and compare their performance.
32211690	10	63	theme	variable	1305:1312	arg1	selection					1314:1322	efficient variable selection	1295:1322	efficient variable selection	1295:1322	Our motivation lies in efficient variable selection to identify glycan biomarkers with regard to accurate prediction as well as interpretability of the model chosen.
32211690	9	64	theme	downstream	1213:1222	arg1	analysis					1224:1231	downstream analysis	1213:1231	downstream analysis available to justify the choice of TA	1213:1269	Nor is systematic investigation of impact of TA on downstream analysis available to justify the choice of TA.
32211690	12	65	theme	error	1712:1716	arg1	types					1630:1634	various types	1622:1634	various types of measurement error in glycans: additive, multiplicative and two-component error	1622:1716	We also address the effect of various types of measurement error in glycans: additive, multiplicative and two-component error.
32211690	5	66	theme	area	656:659	arg1	TA					687:688	TA	687:688	TA	687:688	This total area (row-wise) normalization (TA) results in so-called compositional data, rendering many standard multivariate statistical methods inappropriate or inapplicable.
32211690	5	66	theme	area	656:659	arg1	normalization					672:684	This total area (row-wise) normalization	645:684	This total area (row-wise) normalization (TA)	645:689	This total area (row-wise) normalization (TA) results in so-called compositional data, rendering many standard multivariate statistical methods inappropriate or inapplicable.
32211690	2	67	theme	between-subject	211:225	arg1	large					289:293	large	289:293	large	289:293	Typically, the between-subject differences in total abundance of raw glycomics data are very large, and it is necessary to reduce the differences, making measurements comparable across samples.
32211690	2	67	theme	between-subject	211:225	arg1	differences					227:237	the between-subject differences	207:237	the between-subject differences in total abundance of raw glycomics data	207:278	Typically, the between-subject differences in total abundance of raw glycomics data are very large, and it is necessary to reduce the differences, making measurements comparable across samples.
32211690	10	68	theme	efficient	1295:1303	arg1	selection					1314:1322	efficient variable selection	1295:1322	efficient variable selection	1295:1322	Our motivation lies in efficient variable selection to identify glycan biomarkers with regard to accurate prediction as well as interpretability of the model chosen.
32211690	9	69	from	investigation	1180:1192	arg1	analysis					1224:1231	downstream analysis	1213:1231	downstream analysis available to justify the choice of TA	1213:1269	Nor is systematic investigation of impact of TA on downstream analysis available to justify the choice of TA.
32211690	10	70	theme	glycan	1336:1341	arg1	biomarkers					1343:1352	glycan biomarkers	1336:1352	glycan biomarkers with regard to accurate prediction as well as interpretability of the model chosen	1336:1435	Our motivation lies in efficient variable selection to identify glycan biomarkers with regard to accurate prediction as well as interpretability of the model chosen.
32211690	2	71	theme	data	275:278	arg1	abundance					248:256	total abundance	242:256	total abundance of raw glycomics data	242:278	Typically, the between-subject differences in total abundance of raw glycomics data are very large, and it is necessary to reduce the differences, making measurements comparable across samples.
32211690	0	72	theme	glycan	67:72	arg1	biomarkers					74:83	sparse glycan biomarkers	60:83	sparse glycan biomarkers	60:83	Choosing proper normalization is essential for discovery of sparse glycan biomarkers.
32211690	4	73	contain	having	589:594	arg1	sample					582:587	each sample	577:587	each sample having the sum of all glycan intensities equal to 100%	577:642	In glycomics, the differences per subject are usually forced to be exactly zero, by scaling each sample having the sum of all glycan intensities equal to 100%.
32211690	4	73	contain	having	589:594	arg2	sum					600:602	the sum	596:602	the sum of all glycan intensities equal to 100%	596:642	In glycomics, the differences per subject are usually forced to be exactly zero, by scaling each sample having the sum of all glycan intensities equal to 100%.
32211690	4	74	theme	glycan	611:616	arg1	intensities					618:628	all glycan intensities	607:628	all glycan intensities equal to 100%	607:642	In glycomics, the differences per subject are usually forced to be exactly zero, by scaling each sample having the sum of all glycan intensities equal to 100%.
32211690	1	75	from	progress	92:99	arg1	analysis					130:137	high-throughput glycomics analysis	104:137	high-throughput glycomics analysis	104:137	Rapid progress in high-throughput glycomics analysis enables the researchers to conduct large sample studies.
32211690	12	76	from	error	1712:1716	arg1	glycans					1660:1666	glycans	1660:1666	glycans: additive, multiplicative	1660:1692	We also address the effect of various types of measurement error in glycans: additive, multiplicative and two-component error.
32211690	0	77	theme	sparse	60:65	arg1	biomarkers					74:83	sparse glycan biomarkers	60:83	sparse glycan biomarkers	60:83	Choosing proper normalization is essential for discovery of sparse glycan biomarkers.
32211690	6	78	theme	spurious	889:896	arg1	results					898:904	spurious results	889:904	spurious results	889:904	Ignoring the compositional nature of the data, moreover, may lead to spurious results.
32211690	2	79	theme	raw	261:263	arg1	data					275:278	raw glycomics data	261:278	raw glycomics data	261:278	Typically, the between-subject differences in total abundance of raw glycomics data are very large, and it is necessary to reduce the differences, making measurements comparable across samples.
32211690	7	80	theme	raw	950:952	arg1	data					954:957	the raw data	946:957	the raw data	946:957	Alternatively, a log-transformation to the raw data can be performed prior to column-wise normalization and implementing standard statistical tools.
32211690	2	81	theme	comparable	363:372	arg1	measurements					350:361	measurements	350:361	measurements comparable across samples	350:387	Typically, the between-subject differences in total abundance of raw glycomics data are very large, and it is necessary to reduce the differences, making measurements comparable across samples.
32211690	12	82	theme	two-component	1698:1710	arg1	error					1712:1716	two-component error	1698:1716	two-component error	1698:1716	We also address the effect of various types of measurement error in glycans: additive, multiplicative and two-component error.
32241428	3	0	theme	amino	536:540	arg1	HPPy					558:561	HPPy	558:561	HPPy	558:561	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	3	0	theme	amino	536:540	arg1	-pyrrole					548:555	hyperbranched poly(amino ester)-pyrrole	517:555	hyperbranched poly(amino ester)-pyrrole (HPPy)	517:562	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	0	1	theme	hyperbranched	98:110	arg1	copolymer					112:120	template-directed hyperbranched copolymer	80:120	template-directed hyperbranched copolymer	80:120	Development of conductive protein-based film reinforced by cellulose nanofibril template-directed hyperbranched copolymer.
32241428	5	2	theme	SP-based	884:891	arg1	film					893:896	the modified SP-based film	871:896	the modified SP-based film	871:896	The tensile stress and toughness of the modified SP-based film increased by 362.1 % and 718.8 %, respectively superior to those of previously reported reinforcing approaches.
32241428	3	3	theme	ester	542:546	arg1	HPPy					558:561	HPPy	558:561	HPPy	558:561	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	3	3	theme	ester	542:546	arg1	-pyrrole					548:555	hyperbranched poly(amino ester)-pyrrole	517:555	hyperbranched poly(amino ester)-pyrrole (HPPy)	517:562	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	6	4	theme	water	1102:1106	arg1	resistance					1108:1117	water resistance	1102:1117	water resistance	1102:1117	Moreover, this biopolymer film exhibited significantly improved electrochemical properties, water resistance, and thermal stability.
32241428	5	5	dep	stress	847:852	arg1	The					835:837	The	835:837	The	835:837	The tensile stress and toughness of the modified SP-based film increased by 362.1 % and 718.8 %, respectively superior to those of previously reported reinforcing approaches.
32241428	5	6	theme	modified	875:882	arg1	film					893:896	the modified SP-based film	871:896	the modified SP-based film	871:896	The tensile stress and toughness of the modified SP-based film increased by 362.1 % and 718.8 %, respectively superior to those of previously reported reinforcing approaches.
32241428	2	7	theme	conductivity	360:371	arg1	properties					295:304	the synergistic properties	279:304	the synergistic properties of high biocompatibility, mechanical performance, and conductivity	279:371	However, achieving the synergistic properties of high biocompatibility, mechanical performance, and conductivity remains a key challenge.
32241428	1	8	theme	ever-increasing	199:213	arg1	attention					215:223	ever-increasing attention	199:223	ever-increasing attention	199:223	Smart conductive soft materials prepared from natural polymers are arousing ever-increasing attention in numerous advanced applications.
32241428	3	9	theme	green	418:422	arg1	strategy					424:431	a novel and green strategy	406:431	a novel and green strategy	406:431	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	5	10	theme	superior	945:952	arg1	%					917:917	362.1 %	911:917	362.1 %	911:917	The tensile stress and toughness of the modified SP-based film increased by 362.1 % and 718.8 %, respectively superior to those of previously reported reinforcing approaches.
32241428	4	11	theme	stable	746:751	arg1	network					753:759	a strong and stable network	733:759	a strong and stable network	733:759	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	3	12	theme	hyperbranched	517:529	arg1	HPPy					558:561	HPPy	558:561	HPPy	558:561	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	3	12	theme	hyperbranched	517:529	arg1	-pyrrole					548:555	hyperbranched poly(amino ester)-pyrrole	517:555	hyperbranched poly(amino ester)-pyrrole (HPPy)	517:562	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	4	13	theme	cross-linking	700:712	arg1	ability					802:808	a remarkable conductive ability	778:808	a remarkable conductive ability to biopolymer materials	778:832	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	13	theme	cross-linking	700:712	arg1	sites					714:718	dynamic cross-linking sites	692:718	dynamic cross-linking sites	692:718	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	13	theme	cross-linking	700:712	arg1	nanohybrids					662:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	2	14	theme	performance	343:353	arg1	properties					295:304	the synergistic properties	279:304	the synergistic properties of high biocompatibility, mechanical performance, and conductivity	279:371	However, achieving the synergistic properties of high biocompatibility, mechanical performance, and conductivity remains a key challenge.
32241428	6	15	theme	improved	1065:1072	arg1	properties					1090:1099	significantly improved electrochemical properties	1051:1099	significantly improved electrochemical properties	1051:1099	Moreover, this biopolymer film exhibited significantly improved electrochemical properties, water resistance, and thermal stability.
32241428	4	16	theme	@	657:657	arg1	ability					802:808	a remarkable conductive ability	778:808	a remarkable conductive ability to biopolymer materials	778:832	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	16	theme	@	657:657	arg1	sites					714:718	dynamic cross-linking sites	692:718	dynamic cross-linking sites	692:718	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	16	theme	@	657:657	arg1	nanohybrids					662:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	3	17	theme	novel	408:412	arg1	strategy					424:431	a novel and green strategy	406:431	a novel and green strategy	406:431	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	5	18	theme	film	893:896	arg1	toughness					858:866	toughness	858:866	toughness	858:866	The tensile stress and toughness of the modified SP-based film increased by 362.1 % and 718.8 %, respectively superior to those of previously reported reinforcing approaches.
32241428	5	18	theme	film	893:896	arg1	stress					847:852	tensile stress	839:852	tensile stress	839:852	The tensile stress and toughness of the modified SP-based film increased by 362.1 % and 718.8 %, respectively superior to those of previously reported reinforcing approaches.
32241428	4	19	theme	remarkable	780:789	arg1	ability					802:808	a remarkable conductive ability	778:808	a remarkable conductive ability to biopolymer materials	778:832	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	19	theme	remarkable	780:789	arg1	sites					714:718	dynamic cross-linking sites	692:718	dynamic cross-linking sites	692:718	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	19	theme	remarkable	780:789	arg1	nanohybrids					662:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	2	20	theme	mechanical	332:341	arg1	performance					343:353	mechanical performance	332:353	mechanical performance	332:353	However, achieving the synergistic properties of high biocompatibility, mechanical performance, and conductivity remains a key challenge.
32241428	3	21	theme	-based	476:481	arg1	composite					483:491	a soy protein (SP)-based composite	458:491	a soy protein (SP)-based composite	458:491	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	7	22	theme	other	1224:1228	arg1	systems					1239:1245	other material systems	1224:1245	other material systems	1224:1245	This synthesis strategy is facile and eco-friendly and can be easily extended to other material systems.
32241428	5	23	theme	reported	977:984	arg1	approaches					998:1007	previously reported reinforcing approaches	966:1007	previously reported reinforcing approaches	966:1007	The tensile stress and toughness of the modified SP-based film increased by 362.1 % and 718.8 %, respectively superior to those of previously reported reinforcing approaches.
32241428	2	24	theme	key	383:385	arg1	challenge					387:395	a key challenge	381:395	a key challenge	381:395	However, achieving the synergistic properties of high biocompatibility, mechanical performance, and conductivity remains a key challenge.
32241428	1	25	theme	numerous	228:235	arg1	applications					246:257	numerous advanced applications	228:257	numerous advanced applications	228:257	Smart conductive soft materials prepared from natural polymers are arousing ever-increasing attention in numerous advanced applications.
32241428	1	26	theme	Smart	123:127	arg1	materials					145:153	Smart conductive soft materials	123:153	Smart conductive soft materials prepared from natural polymers	123:184	Smart conductive soft materials prepared from natural polymers are arousing ever-increasing attention in numerous advanced applications.
32241428	1	27	theme	advanced	237:244	arg1	applications					246:257	numerous advanced applications	228:257	numerous advanced applications	228:257	Smart conductive soft materials prepared from natural polymers are arousing ever-increasing attention in numerous advanced applications.
32241428	0	28	theme	protein-based	26:38	arg1	film					40:43	conductive protein-based film	15:43	conductive protein-based film reinforced by cellulose	15:67	Development of conductive protein-based film reinforced by cellulose nanofibril template-directed hyperbranched copolymer.
32241428	3	29	theme	cellulose	614:622	arg1	nanofibril					624:633	cellulose nanofibril	614:633	cellulose nanofibril (CNF)	614:639	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	3	29	theme	cellulose	614:622	arg1	CNF					636:638	CNF	636:638	CNF	636:638	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	1	30	theme	conductive	129:138	arg1	materials					145:153	Smart conductive soft materials	123:153	Smart conductive soft materials prepared from natural polymers	123:184	Smart conductive soft materials prepared from natural polymers are arousing ever-increasing attention in numerous advanced applications.
32241428	6	31	theme	electrochemical	1074:1088	arg1	properties					1090:1099	significantly improved electrochemical properties	1051:1099	significantly improved electrochemical properties	1051:1099	Moreover, this biopolymer film exhibited significantly improved electrochemical properties, water resistance, and thermal stability.
32241428	0	32	theme	conductive	15:24	arg1	film					40:43	conductive protein-based film	15:43	conductive protein-based film reinforced by cellulose	15:67	Development of conductive protein-based film reinforced by cellulose nanofibril template-directed hyperbranched copolymer.
32241428	1	33	theme	soft	140:143	arg1	materials					145:153	Smart conductive soft materials	123:153	Smart conductive soft materials prepared from natural polymers	123:184	Smart conductive soft materials prepared from natural polymers are arousing ever-increasing attention in numerous advanced applications.
32241428	6	34	theme	biopolymer	1025:1034	arg1	film					1036:1039	this biopolymer film	1020:1039	this biopolymer film	1020:1039	Moreover, this biopolymer film exhibited significantly improved electrochemical properties, water resistance, and thermal stability.
32241428	4	35	theme	CNF	658:660	arg1	ability					802:808	a remarkable conductive ability	778:808	a remarkable conductive ability to biopolymer materials	778:832	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	35	theme	CNF	658:660	arg1	sites					714:718	dynamic cross-linking sites	692:718	dynamic cross-linking sites	692:718	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	35	theme	CNF	658:660	arg1	nanohybrids					662:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	36	theme	formed	646:651	arg1	ability					802:808	a remarkable conductive ability	778:808	a remarkable conductive ability to biopolymer materials	778:832	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	36	theme	formed	646:651	arg1	sites					714:718	dynamic cross-linking sites	692:718	dynamic cross-linking sites	692:718	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	36	theme	formed	646:651	arg1	nanohybrids					662:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	0	37	theme	film	40:43	arg1	Development					0:10	Development	0:10	Development of conductive protein-based film reinforced by cellulose	0:67	Development of conductive protein-based film reinforced by cellulose nanofibril template-directed hyperbranched copolymer.
32241428	2	38	theme	synergistic	283:293	arg1	properties					295:304	the synergistic properties	279:304	the synergistic properties of high biocompatibility, mechanical performance, and conductivity	279:371	However, achieving the synergistic properties of high biocompatibility, mechanical performance, and conductivity remains a key challenge.
32241428	5	39	theme	tensile	839:845	arg1	stress					847:852	tensile stress	839:852	tensile stress	839:852	The tensile stress and toughness of the modified SP-based film increased by 362.1 % and 718.8 %, respectively superior to those of previously reported reinforcing approaches.
32241428	4	40	theme	biopolymer	813:822	arg1	materials					824:832	biopolymer materials	813:832	biopolymer materials	813:832	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	3	41	theme	poly	531:534	arg1	HPPy					558:561	HPPy	558:561	HPPy	558:561	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	3	41	theme	poly	531:534	arg1	-pyrrole					548:555	hyperbranched poly(amino ester)-pyrrole	517:555	hyperbranched poly(amino ester)-pyrrole (HPPy)	517:562	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	7	42	theme	synthesis	1148:1156	arg1	strategy					1158:1165	This synthesis strategy	1143:1165	This synthesis strategy	1143:1165	This synthesis strategy is facile and eco-friendly and can be easily extended to other material systems.
32241428	7	43	theme	material	1230:1237	arg1	systems					1239:1245	other material systems	1224:1245	other material systems	1224:1245	This synthesis strategy is facile and eco-friendly and can be easily extended to other material systems.
32241428	3	44	theme	bio	598:600	arg1	template					602:609	a bio template	596:609	a bio template of cellulose nanofibril (CNF)	596:639	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	4	45	theme	dynamic	692:698	arg1	ability					802:808	a remarkable conductive ability	778:808	a remarkable conductive ability to biopolymer materials	778:832	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	45	theme	dynamic	692:698	arg1	sites					714:718	dynamic cross-linking sites	692:718	dynamic cross-linking sites	692:718	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	45	theme	dynamic	692:698	arg1	nanohybrids					662:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	5	46	theme	reinforcing	986:996	arg1	approaches					998:1007	previously reported reinforcing approaches	966:1007	previously reported reinforcing approaches	966:1007	The tensile stress and toughness of the modified SP-based film increased by 362.1 % and 718.8 %, respectively superior to those of previously reported reinforcing approaches.
32241428	4	47	theme	conductive	791:800	arg1	ability					802:808	a remarkable conductive ability	778:808	a remarkable conductive ability to biopolymer materials	778:832	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	47	theme	conductive	791:800	arg1	sites					714:718	dynamic cross-linking sites	692:718	dynamic cross-linking sites	692:718	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	47	theme	conductive	791:800	arg1	nanohybrids					662:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	6	48	theme	thermal	1124:1130	arg1	stability					1132:1140	thermal stability	1124:1140	thermal stability	1124:1140	Moreover, this biopolymer film exhibited significantly improved electrochemical properties, water resistance, and thermal stability.
32241428	3	49	theme	in	568:569	arg1	polymerization					576:589	in situ polymerization	568:589	in situ polymerization into a bio template of cellulose nanofibril (CNF)	568:639	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	2	50	theme	biocompatibility	314:329	arg1	properties					295:304	the synergistic properties	279:304	the synergistic properties of high biocompatibility, mechanical performance, and conductivity	279:371	However, achieving the synergistic properties of high biocompatibility, mechanical performance, and conductivity remains a key challenge.
32241428	4	51	theme	strong	735:740	arg1	network					753:759	a strong and stable network	733:759	a strong and stable network	733:759	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	1	52	theme	natural	169:175	arg1	polymers					177:184	natural polymers	169:184	natural polymers	169:184	Smart conductive soft materials prepared from natural polymers are arousing ever-increasing attention in numerous advanced applications.
32241428	0	53	theme	template-directed	80:96	arg1	copolymer					112:120	template-directed hyperbranched copolymer	80:120	template-directed hyperbranched copolymer	80:120	Development of conductive protein-based film reinforced by cellulose nanofibril template-directed hyperbranched copolymer.
32241428	2	54	theme	high	309:312	arg1	biocompatibility					314:329	high biocompatibility	309:329	high biocompatibility	309:329	However, achieving the synergistic properties of high biocompatibility, mechanical performance, and conductivity remains a key challenge.
32241428	3	55	dep	in	568:569	arg1	situ					571:574	situ	571:574	situ	571:574	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	4	56	theme	HPPy	653:656	arg1	ability					802:808	a remarkable conductive ability	778:808	a remarkable conductive ability to biopolymer materials	778:832	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	56	theme	HPPy	653:656	arg1	sites					714:718	dynamic cross-linking sites	692:718	dynamic cross-linking sites	692:718	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	4	56	theme	HPPy	653:656	arg1	nanohybrids					662:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids	642:672	The formed HPPy@CNF nanohybrids not only serve as dynamic cross-linking sites to construct a strong and stable network, but also impart a remarkable conductive ability to biopolymer materials.
32241428	3	57	theme	nanofibril	624:633	arg1	template					602:609	a bio template	596:609	a bio template of cellulose nanofibril (CNF)	596:639	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32241428	3	58	theme	-pyrrole	548:555	arg1	incorporation					500:512	the incorporation	496:512	the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy)	496:562	Herein, a novel and green strategy is proposed to fabricate a soy protein (SP)-based composite by the incorporation of hyperbranched poly(amino ester)-pyrrole (HPPy) via in situ polymerization into a bio template of cellulose nanofibril (CNF).
32078304	2	0	theme	slow	362:365	arg1	rate					383:386	its inherent slow crystallization rate	349:386	its inherent slow crystallization rate	349:386	However, its inherent slow crystallization rate limits its thermomechanical properties and therefore its applications.
32078304	0	1	theme	Mechanical	101:110	arg1	Properties					124:133	Mechanical and Thermal Properties	101:133	Mechanical and Thermal Properties	101:133	Interphase Design of Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites for Mechanical and Thermal Properties Tuning.
32078304	2	2	theme	inherent	353:360	arg1	rate					383:386	its inherent slow crystallization rate	349:386	its inherent slow crystallization rate	349:386	However, its inherent slow crystallization rate limits its thermomechanical properties and therefore its applications.
32078304	6	3	theme	properties	1078:1087	arg1	enhancement					1037:1047	an enhancement	1034:1047	an enhancement of the PHBV thermomechanical properties	1034:1087	The results demonstrate that butyrate-modified CNCs, mimicking the PHBV chemical structure, brought a considerable improvement toward the CNCs/matrix interface, leading to an enhancement of the PHBV thermomechanical properties via a more efficient stress transfer, especially above its glass transition.
32078304	5	4	theme	CNCs	772:775	arg1	esterification					785:798	the CNCs surface esterification	768:798	the CNCs surface esterification	768:798	Beyond the improved dispersion, the CNCs surface esterification affected the thermal and thermomechanical properties of PHBV.
32078304	4	5	theme	ester	627:631	arg1	moieties					633:640	Different ester moieties	617:640	Different ester moieties from the CNCs	617:654	Different ester moieties from the CNCs were thereby produced through a green one-pot hydrolysis/Fisher esterification.
32078304	0	6	theme	Thermal	116:122	arg1	Properties					124:133	Mechanical and Thermal Properties	101:133	Mechanical and Thermal Properties	101:133	Interphase Design of Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites for Mechanical and Thermal Properties Tuning.
32078304	6	7	theme	considerable	964:975	arg1	improvement					977:987	a considerable improvement	962:987	a considerable improvement	962:987	The results demonstrate that butyrate-modified CNCs, mimicking the PHBV chemical structure, brought a considerable improvement toward the CNCs/matrix interface, leading to an enhancement of the PHBV thermomechanical properties via a more efficient stress transfer, especially above its glass transition.
32078304	4	8	theme	Different	617:625	arg1	moieties					633:640	Different ester moieties	617:640	Different ester moieties from the CNCs	617:654	Different ester moieties from the CNCs were thereby produced through a green one-pot hydrolysis/Fisher esterification.
32078304	6	9	theme	glass	1148:1152	arg1	transition					1154:1163	its glass transition	1144:1163	its glass transition	1144:1163	The results demonstrate that butyrate-modified CNCs, mimicking the PHBV chemical structure, brought a considerable improvement toward the CNCs/matrix interface, leading to an enhancement of the PHBV thermomechanical properties via a more efficient stress transfer, especially above its glass transition.
32078304	4	10	theme	green	688:692	arg1	esterification					720:733	a green one-pot hydrolysis/Fisher esterification	686:733	a green one-pot hydrolysis/Fisher esterification	686:733	Different ester moieties from the CNCs were thereby produced through a green one-pot hydrolysis/Fisher esterification.
32078304	3	11	theme	biosourced	556:565	arg1	nucleating					567:576	green and biosourced nucleating and reinforcing agent	546:598	nucleating	567:576	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	3	11	theme	biosourced	556:565	arg1	nanocrystals					500:511	surface-modified cellulose nanocrystals	473:511	surface-modified cellulose nanocrystals (CNCs)	473:518	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	2	12	theme	thermomechanical	399:414	arg1	properties					416:425	its thermomechanical properties	395:425	its thermomechanical properties	395:425	However, its inherent slow crystallization rate limits its thermomechanical properties and therefore its applications.
32078304	5	13	theme	thermomechanical	825:840	arg1	properties					842:851	the thermal and thermomechanical properties	809:851	the thermal and thermomechanical properties of PHBV	809:859	Beyond the improved dispersion, the CNCs surface esterification affected the thermal and thermomechanical properties of PHBV.
32078304	4	14	theme	hydrolysis/Fisher	702:718	arg1	esterification					720:733	a green one-pot hydrolysis/Fisher esterification	686:733	a green one-pot hydrolysis/Fisher esterification	686:733	Different ester moieties from the CNCs were thereby produced through a green one-pot hydrolysis/Fisher esterification.
32078304	0	15	theme	Interphase	0:9	arg1	Design					11:16	Interphase Design	0:16	Interphase Design of Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites for Mechanical and Thermal Properties Tuning.	0:141	Interphase Design of Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites for Mechanical and Thermal Properties Tuning.
32078304	1	16	theme	oil-based	269:277	arg1	thermoplastics					279:292	oil-based thermoplastics	269:292	oil-based thermoplastics due to its biodegradability and renewability	269:337	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	6	17	theme	butyrate-modified	891:907	arg1	CNCs					909:912	butyrate-modified CNCs	891:912	butyrate-modified CNCs	891:912	The results demonstrate that butyrate-modified CNCs, mimicking the PHBV chemical structure, brought a considerable improvement toward the CNCs/matrix interface, leading to an enhancement of the PHBV thermomechanical properties via a more efficient stress transfer, especially above its glass transition.
32078304	3	18	theme	PHBV	604:607	arg1	matrix					609:614	PHBV matrix	604:614	PHBV matrix	604:614	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	4	19	theme	one-pot	694:700	arg1	esterification					720:733	a green one-pot hydrolysis/Fisher esterification	686:733	a green one-pot hydrolysis/Fisher esterification	686:733	Different ester moieties from the CNCs were thereby produced through a green one-pot hydrolysis/Fisher esterification.
32078304	0	20	theme	Cellulose	21:29	arg1	Bionanocomposites					79:95	Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites	21:95	Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites	21:95	Interphase Design of Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites for Mechanical and Thermal Properties Tuning.
32078304	5	21	theme	improved	747:754	arg1	dispersion					756:765	the improved dispersion	743:765	the improved dispersion	743:765	Beyond the improved dispersion, the CNCs surface esterification affected the thermal and thermomechanical properties of PHBV.
32078304	3	22	theme	reinforcing	582:592	arg1	agent					594:598	green and biosourced nucleating and reinforcing agent	546:598	agent	594:598	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	3	22	theme	reinforcing	582:592	arg1	nanocrystals					500:511	surface-modified cellulose nanocrystals	473:511	surface-modified cellulose nanocrystals (CNCs)	473:518	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	3	23	theme	cellulose	490:498	arg1	nucleating					567:576	green and biosourced nucleating and reinforcing agent	546:598	nucleating	567:576	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	3	23	theme	cellulose	490:498	arg1	agent					594:598	green and biosourced nucleating and reinforcing agent	546:598	agent	594:598	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	3	23	theme	cellulose	490:498	arg1	CNCs					514:517	CNCs	514:517	CNCs	514:517	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	3	23	theme	cellulose	490:498	arg1	nanocrystals					500:511	surface-modified cellulose nanocrystals	473:511	surface-modified cellulose nanocrystals (CNCs)	473:518	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	1	24	theme	due	294:296	arg1	thermoplastics					279:292	oil-based thermoplastics	269:292	oil-based thermoplastics due to its biodegradability and renewability	269:337	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	1	25	with	polyester	215:223	arg1	potential					239:247	a strong potential	230:247	a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability	230:337	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	6	26	theme	chemical	934:941	arg1	structure					943:951	the PHBV chemical structure	925:951	the PHBV chemical structure	925:951	The results demonstrate that butyrate-modified CNCs, mimicking the PHBV chemical structure, brought a considerable improvement toward the CNCs/matrix interface, leading to an enhancement of the PHBV thermomechanical properties via a more efficient stress transfer, especially above its glass transition.
32078304	1	27	theme	bacterial	205:213	arg1	-ran-					167:171	Poly[(3-hydroxybutyrate)-ran-	143:171	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV)	143:198	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	1	27	theme	bacterial	205:213	arg1	polyester					215:223	a bacterial polyester	203:223	a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability	203:337	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	0	28	theme	Nanocrystals/Poly	31:47	arg1	Bionanocomposites					79:95	Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites	21:95	Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites	21:95	Interphase Design of Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites for Mechanical and Thermal Properties Tuning.
32078304	6	29	theme	PHBV	929:932	arg1	structure					943:951	the PHBV chemical structure	925:951	the PHBV chemical structure	925:951	The results demonstrate that butyrate-modified CNCs, mimicking the PHBV chemical structure, brought a considerable improvement toward the CNCs/matrix interface, leading to an enhancement of the PHBV thermomechanical properties via a more efficient stress transfer, especially above its glass transition.
32078304	3	30	theme	surface-modified	473:488	arg1	nucleating					567:576	green and biosourced nucleating and reinforcing agent	546:598	nucleating	567:576	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	3	30	theme	surface-modified	473:488	arg1	agent					594:598	green and biosourced nucleating and reinforcing agent	546:598	agent	594:598	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	3	30	theme	surface-modified	473:488	arg1	CNCs					514:517	CNCs	514:517	CNCs	514:517	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	3	30	theme	surface-modified	473:488	arg1	nanocrystals					500:511	surface-modified cellulose nanocrystals	473:511	surface-modified cellulose nanocrystals (CNCs)	473:518	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	5	31	theme	PHBV	856:859	arg1	properties					842:851	the thermal and thermomechanical properties	809:851	the thermal and thermomechanical properties of PHBV	809:859	Beyond the improved dispersion, the CNCs surface esterification affected the thermal and thermomechanical properties of PHBV.
32078304	5	32	theme	thermal	813:819	arg1	properties					842:851	the thermal and thermomechanical properties	809:851	the thermal and thermomechanical properties of PHBV	809:859	Beyond the improved dispersion, the CNCs surface esterification affected the thermal and thermomechanical properties of PHBV.
32078304	1	33	theme	Poly[	143:147	arg1	PHBV					194:197	PHBV	194:197	PHBV	194:197	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	1	33	theme	Poly[	143:147	arg1	3-hydroxyvalerate					173:189	3-hydroxyvalerate	173:189	3-hydroxyvalerate	173:189	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	1	33	theme	Poly[	143:147	arg1	-ran-					167:171	Poly[(3-hydroxybutyrate)-ran-	143:171	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV)	143:198	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	1	33	theme	Poly[	143:147	arg1	polyester					215:223	a bacterial polyester	203:223	a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability	203:337	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	0	34	theme	hydroxybutyrate-ran-valerate	49:76	arg1	Bionanocomposites					79:95	Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites	21:95	Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites	21:95	Interphase Design of Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites for Mechanical and Thermal Properties Tuning.
32078304	6	35	theme	thermomechanical	1061:1076	arg1	properties					1078:1087	the PHBV thermomechanical properties	1052:1087	the PHBV thermomechanical properties	1052:1087	The results demonstrate that butyrate-modified CNCs, mimicking the PHBV chemical structure, brought a considerable improvement toward the CNCs/matrix interface, leading to an enhancement of the PHBV thermomechanical properties via a more efficient stress transfer, especially above its glass transition.
32078304	1	36	theme	3-hydroxybutyrate	149:165	arg1	PHBV					194:197	PHBV	194:197	PHBV	194:197	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	1	36	theme	3-hydroxybutyrate	149:165	arg1	3-hydroxyvalerate					173:189	3-hydroxyvalerate	173:189	3-hydroxyvalerate	173:189	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	1	36	theme	3-hydroxybutyrate	149:165	arg1	-ran-					167:171	Poly[(3-hydroxybutyrate)-ran-	143:171	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV)	143:198	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	1	36	theme	3-hydroxybutyrate	149:165	arg1	polyester					215:223	a bacterial polyester	203:223	a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability	203:337	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	6	37	theme	stress	1110:1115	arg1	transfer					1117:1124	a more efficient stress transfer	1093:1124	a more efficient stress transfer	1093:1124	The results demonstrate that butyrate-modified CNCs, mimicking the PHBV chemical structure, brought a considerable improvement toward the CNCs/matrix interface, leading to an enhancement of the PHBV thermomechanical properties via a more efficient stress transfer, especially above its glass transition.
32078304	3	38	theme	green	546:550	arg1	nucleating					567:576	green and biosourced nucleating and reinforcing agent	546:598	nucleating	567:576	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	3	38	theme	green	546:550	arg1	nanocrystals					500:511	surface-modified cellulose nanocrystals	473:511	surface-modified cellulose nanocrystals (CNCs)	473:518	In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix.
32078304	6	39	theme	efficient	1100:1108	arg1	transfer					1117:1124	a more efficient stress transfer	1093:1124	a more efficient stress transfer	1093:1124	The results demonstrate that butyrate-modified CNCs, mimicking the PHBV chemical structure, brought a considerable improvement toward the CNCs/matrix interface, leading to an enhancement of the PHBV thermomechanical properties via a more efficient stress transfer, especially above its glass transition.
32078304	4	40	from	CNCs	651:654	arg1	moieties					633:640	Different ester moieties	617:640	Different ester moieties from the CNCs	617:654	Different ester moieties from the CNCs were thereby produced through a green one-pot hydrolysis/Fisher esterification.
32078304	1	41	dep	a	252:252	arg1	substitute					254:263	substitute	254:263	substitute for oil-based thermoplastics due to its biodegradability and renewability	254:337	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	0	42	dep	Design	11:16	arg1	Tuning					135:140	Tuning	135:140	Interphase Design of Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites for Mechanical and Thermal Properties Tuning.	0:141	Interphase Design of Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites for Mechanical and Thermal Properties Tuning.
32078304	1	43	theme	strong	232:237	arg1	potential					239:247	a strong potential	230:247	a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability	230:337	Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability.
32078304	0	44	theme	Bionanocomposites	79:95	arg1	Design					11:16	Interphase Design	0:16	Interphase Design of Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites for Mechanical and Thermal Properties Tuning.	0:141	Interphase Design of Cellulose Nanocrystals/Poly(hydroxybutyrate-ran-valerate) Bionanocomposites for Mechanical and Thermal Properties Tuning.
32078304	6	45	theme	CNCs/matrix	1000:1010	arg1	interface					1012:1020	the CNCs/matrix interface	996:1020	the CNCs/matrix interface	996:1020	The results demonstrate that butyrate-modified CNCs, mimicking the PHBV chemical structure, brought a considerable improvement toward the CNCs/matrix interface, leading to an enhancement of the PHBV thermomechanical properties via a more efficient stress transfer, especially above its glass transition.
32078304	2	46	theme	crystallization	367:381	arg1	rate					383:386	its inherent slow crystallization rate	349:386	its inherent slow crystallization rate	349:386	However, its inherent slow crystallization rate limits its thermomechanical properties and therefore its applications.
32078304	5	47	theme	surface	777:783	arg1	esterification					785:798	the CNCs surface esterification	768:798	the CNCs surface esterification	768:798	Beyond the improved dispersion, the CNCs surface esterification affected the thermal and thermomechanical properties of PHBV.
33142614	4	0	theme	1.5	446:448	arg1	%					450:450	%	450:450	%	450:450	The film with 1.5 % L. lactis showed the best performance and the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.
33142614	4	1	theme	transmission	517:528	arg1	rate					530:533	the lowest water vapor transmission rate	494:533	the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.	494:557	The film with 1.5 % L. lactis showed the best performance and the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.
33142614	0	2	theme	edible	98:103	arg1	films					105:109	starch/carboxymethyl cellulose edible films	67:109	starch/carboxymethyl cellulose edible films	67:109	Improving nisin production by encapsulated Lactococcus lactis with starch/carboxymethyl cellulose edible films.
33142614	7	3	theme	low	971:973	arg1	content					984:990	low moisture content	971:990	low moisture content	971:990	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	2	4	theme	composite	286:294	arg1	film					296:299	the composite film	282:299	the composite film	282:299	At a CMC:NS ratio of 5:5, the composite film had the best comprehensive properties.
33142614	4	5	theme	vapor	511:515	arg1	rate					530:533	the lowest water vapor transmission rate	494:533	the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.	494:557	The film with 1.5 % L. lactis showed the best performance and the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.
33142614	4	6	theme	L.	452:453	arg1	lactis					455:460	1.5 % L. lactis	446:460	1.5 % L. lactis	446:460	The film with 1.5 % L. lactis showed the best performance and the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.
33142614	5	7	theme	edible	576:581	arg1	film					583:586	the edible film	572:586	the edible film	572:586	In addition, the edible film retained a viable count of 5.64 log CFU/g of L. lactis when stored at 4 °C for 30 days.
33142614	1	8	from	film	164:167	arg1	embedded					150:157	embedded	150:157	embedded	150:157	In this study, Lactococcus lactis was embedded in a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method.
33142614	7	9	contain	containing	960:969	arg1	foods					954:958	foods	954:958	foods containing low moisture content	954:990	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	7	9	contain	containing	960:969	arg2	content					984:990	low moisture content	971:990	low moisture content	971:990	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	5	10	theme	L.	633:634	arg1	lactis					636:641	L. lactis	633:641	L. lactis	633:641	In addition, the edible film retained a viable count of 5.64 log CFU/g of L. lactis when stored at 4 °C for 30 days.
33142614	7	11	theme	foods	954:958	arg1	packaging					941:949	the active packaging	930:949	the active packaging of foods containing low moisture content	930:990	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	1	12	from	embedded	150:157	arg1	film					164:167	a film	162:167	a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method	162:253	In this study, Lactococcus lactis was embedded in a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method.
33142614	1	12	from	embedded	150:157	arg1	study					120:124	this study	115:124	this study	115:124	In this study, Lactococcus lactis was embedded in a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method.
33142614	1	13	theme	casting	240:246	arg1	method					248:253	a casting method	238:253	a casting method	238:253	In this study, Lactococcus lactis was embedded in a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method.
33142614	5	14	theme	lactis	636:641	arg1	CFU/g					624:628	5.64 log CFU/g	615:628	5.64 log CFU/g of L. lactis	615:641	In addition, the edible film retained a viable count of 5.64 log CFU/g of L. lactis when stored at 4 °C for 30 days.
33142614	7	15	theme	active	934:939	arg1	packaging					941:949	the active packaging	930:949	the active packaging of foods containing low moisture content	930:990	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	2	16	theme	comprehensive	314:326	arg1	properties					328:337	the best comprehensive properties	305:337	the best comprehensive properties	305:337	At a CMC:NS ratio of 5:5, the composite film had the best comprehensive properties.
33142614	2	17	contain	had	301:303	arg1	film					296:299	the composite film	282:299	the composite film	282:299	At a CMC:NS ratio of 5:5, the composite film had the best comprehensive properties.
33142614	2	17	contain	had	301:303	arg2	properties					328:337	the best comprehensive properties	305:337	the best comprehensive properties	305:337	At a CMC:NS ratio of 5:5, the composite film had the best comprehensive properties.
33142614	3	18	theme	microscopy	358:367	arg1	images					369:374	Scanning electron microscopy images	340:374	Scanning electron microscopy images	340:374	Scanning electron microscopy images clearly showed that L. lactis was effectively embedded.
33142614	1	19	theme	corn	172:175	arg1	starch					177:182	corn starch	172:182	corn starch (NS)	172:187	In this study, Lactococcus lactis was embedded in a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method.
33142614	1	19	theme	corn	172:175	arg1	CMC					218:220	CMC	218:220	CMC	218:220	In this study, Lactococcus lactis was embedded in a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method.
33142614	1	19	theme	corn	172:175	arg1	NS					185:186	NS	185:186	NS	185:186	In this study, Lactococcus lactis was embedded in a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method.
33142614	0	20	theme	nisin	10:14	arg1	production					16:25	nisin production	10:25	nisin production	10:25	Improving nisin production by encapsulated Lactococcus lactis with starch/carboxymethyl cellulose edible films.
33142614	6	21	theme	highest	727:733	arg1	release					735:741	the highest release	723:741	the highest release of nisin (3.35 mg/mL)	723:763	The composite film with 1.5 % L. lactis showed the highest release of nisin (3.35 mg/mL) and good antibacterial activity against Staphylococcus aureus (53.53 %) after 8 days.
33142614	1	22	theme	starch	177:182	arg1	film					164:167	a film	162:167	a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method	162:253	In this study, Lactococcus lactis was embedded in a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method.
33142614	7	23	theme	viable	884:889	arg1	film					874:877	this edible film	862:877	this edible film	862:877	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	7	23	theme	viable	884:889	arg1	strategy					917:924	a viable alternative antimicrobial strategy	882:924	a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content	882:990	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	6	24	theme	antibacterial	774:786	arg1	activity					788:795	good antibacterial activity	769:795	good antibacterial activity against Staphylococcus aureus (53.53 %)	769:835	The composite film with 1.5 % L. lactis showed the highest release of nisin (3.35 mg/mL) and good antibacterial activity against Staphylococcus aureus (53.53 %) after 8 days.
33142614	2	25	theme	NS	265:266	arg1	ratio					268:272	a CMC:NS ratio	259:272	a CMC:NS ratio of 5:5	259:279	At a CMC:NS ratio of 5:5, the composite film had the best comprehensive properties.
33142614	2	26	theme	best	309:312	arg1	properties					328:337	the best comprehensive properties	305:337	the best comprehensive properties	305:337	At a CMC:NS ratio of 5:5, the composite film had the best comprehensive properties.
33142614	7	27	theme	antimicrobial	903:915	arg1	film					874:877	this edible film	862:877	this edible film	862:877	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	7	27	theme	antimicrobial	903:915	arg1	strategy					917:924	a viable alternative antimicrobial strategy	882:924	a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content	882:990	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	6	28	with	film	690:693	arg1	lactis					709:714	1.5 % L. lactis	700:714	1.5 % L. lactis	700:714	The composite film with 1.5 % L. lactis showed the highest release of nisin (3.35 mg/mL) and good antibacterial activity against Staphylococcus aureus (53.53 %) after 8 days.
33142614	4	29	theme	water	505:509	arg1	rate					530:533	the lowest water vapor transmission rate	494:533	the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.	494:557	The film with 1.5 % L. lactis showed the best performance and the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.
33142614	5	30	theme	5.64	615:618	arg1	CFU/g					624:628	5.64 log CFU/g	615:628	5.64 log CFU/g of L. lactis	615:641	In addition, the edible film retained a viable count of 5.64 log CFU/g of L. lactis when stored at 4 °C for 30 days.
33142614	2	31	theme	CMC	261:263	arg1	ratio					268:272	a CMC:NS ratio	259:272	a CMC:NS ratio of 5:5	259:279	At a CMC:NS ratio of 5:5, the composite film had the best comprehensive properties.
33142614	0	32	theme	Lactococcus	43:53	arg1	lactis					55:60	encapsulated Lactococcus lactis	30:60	encapsulated Lactococcus lactis with starch/carboxymethyl cellulose edible films	30:109	Improving nisin production by encapsulated Lactococcus lactis with starch/carboxymethyl cellulose edible films.
33142614	4	33	theme	lowest	498:503	arg1	rate					530:533	the lowest water vapor transmission rate	494:533	the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.	494:557	The film with 1.5 % L. lactis showed the best performance and the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.
33142614	5	34	theme	log	620:622	arg1	CFU/g					624:628	5.64 log CFU/g	615:628	5.64 log CFU/g of L. lactis	615:641	In addition, the edible film retained a viable count of 5.64 log CFU/g of L. lactis when stored at 4 °C for 30 days.
33142614	4	35	dep	rate	530:533	arg1	Pa.					555:557	Pa.	555:557	Pa.	555:557	The film with 1.5 % L. lactis showed the best performance and the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.
33142614	7	36	theme	moisture	975:982	arg1	content					984:990	low moisture content	971:990	low moisture content	971:990	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	0	37	theme	encapsulated	30:41	arg1	lactis					55:60	encapsulated Lactococcus lactis	30:60	encapsulated Lactococcus lactis with starch/carboxymethyl cellulose edible films	30:109	Improving nisin production by encapsulated Lactococcus lactis with starch/carboxymethyl cellulose edible films.
33142614	5	38	theme	CFU/g	624:628	arg1	count					606:610	a viable count	597:610	a viable count of 5.64 log CFU/g of L. lactis	597:641	In addition, the edible film retained a viable count of 5.64 log CFU/g of L. lactis when stored at 4 °C for 30 days.
33142614	1	39	theme	carboxymethyl	193:205	arg1	cellulose					207:215	carboxymethyl cellulose	193:215	carboxymethyl cellulose	193:215	In this study, Lactococcus lactis was embedded in a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method.
33142614	3	40	theme	Scanning	340:347	arg1	microscopy					358:367	Scanning electron microscopy	340:367	Scanning electron microscopy images	340:374	Scanning electron microscopy images clearly showed that L. lactis was effectively embedded.
33142614	6	41	theme	composite	680:688	arg1	film					690:693	The composite film	676:693	The composite film with 1.5 % L. lactis	676:714	The composite film with 1.5 % L. lactis showed the highest release of nisin (3.35 mg/mL) and good antibacterial activity against Staphylococcus aureus (53.53 %) after 8 days.
33142614	6	42	theme	nisin	746:750	arg1	activity					788:795	good antibacterial activity	769:795	good antibacterial activity against Staphylococcus aureus (53.53 %)	769:835	The composite film with 1.5 % L. lactis showed the highest release of nisin (3.35 mg/mL) and good antibacterial activity against Staphylococcus aureus (53.53 %) after 8 days.
33142614	6	42	theme	nisin	746:750	arg1	release					735:741	the highest release	723:741	the highest release of nisin (3.35 mg/mL)	723:763	The composite film with 1.5 % L. lactis showed the highest release of nisin (3.35 mg/mL) and good antibacterial activity against Staphylococcus aureus (53.53 %) after 8 days.
33142614	7	43	theme	alternative	891:901	arg1	film					874:877	this edible film	862:877	this edible film	862:877	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	7	43	theme	alternative	891:901	arg1	strategy					917:924	a viable alternative antimicrobial strategy	882:924	a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content	882:990	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	3	44	theme	electron	349:356	arg1	microscopy					358:367	Scanning electron microscopy	340:367	Scanning electron microscopy images	340:374	Scanning electron microscopy images clearly showed that L. lactis was effectively embedded.
33142614	6	45	theme	good	769:772	arg1	activity					788:795	good antibacterial activity	769:795	good antibacterial activity against Staphylococcus aureus (53.53 %)	769:835	The composite film with 1.5 % L. lactis showed the highest release of nisin (3.35 mg/mL) and good antibacterial activity against Staphylococcus aureus (53.53 %) after 8 days.
33142614	7	46	theme	edible	867:872	arg1	film					874:877	this edible film	862:877	this edible film	862:877	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	7	46	theme	edible	867:872	arg1	strategy					917:924	a viable alternative antimicrobial strategy	882:924	a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content	882:990	Therefore, this edible film is a viable alternative antimicrobial strategy for the active packaging of foods containing low moisture content.
33142614	1	47	theme	Lactococcus	127:137	arg1	lactis					139:144	Lactococcus lactis	127:144	Lactococcus lactis	127:144	In this study, Lactococcus lactis was embedded in a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method.
33142614	4	48	theme	best	473:476	arg1	performance					478:488	the best performance	469:488	the best performance	469:488	The film with 1.5 % L. lactis showed the best performance and the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.
33142614	5	49	theme	viable	599:604	arg1	count					606:610	a viable count	597:610	a viable count of 5.64 log CFU/g of L. lactis	597:641	In addition, the edible film retained a viable count of 5.64 log CFU/g of L. lactis when stored at 4 °C for 30 days.
33142614	6	50	theme	L.	706:707	arg1	lactis					709:714	1.5 % L. lactis	700:714	1.5 % L. lactis	700:714	The composite film with 1.5 % L. lactis showed the highest release of nisin (3.35 mg/mL) and good antibacterial activity against Staphylococcus aureus (53.53 %) after 8 days.
33142614	2	51	theme	5:5	277:279	arg1	ratio					268:272	a CMC:NS ratio	259:272	a CMC:NS ratio of 5:5	259:279	At a CMC:NS ratio of 5:5, the composite film had the best comprehensive properties.
33142614	1	52	from	study	120:124	arg1	embedded					150:157	embedded	150:157	embedded	150:157	In this study, Lactococcus lactis was embedded in a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method.
33142614	1	53	theme	cellulose	207:215	arg1	film					164:167	a film	162:167	a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method	162:253	In this study, Lactococcus lactis was embedded in a film of corn starch (NS) and carboxymethyl cellulose (CMC) prepared using a casting method.
33142614	6	54	theme	%	704:704	arg1	lactis					709:714	1.5 % L. lactis	700:714	1.5 % L. lactis	700:714	The composite film with 1.5 % L. lactis showed the highest release of nisin (3.35 mg/mL) and good antibacterial activity against Staphylococcus aureus (53.53 %) after 8 days.
33142614	0	55	theme	cellulose	88:96	arg1	films					105:109	starch/carboxymethyl cellulose edible films	67:109	starch/carboxymethyl cellulose edible films	67:109	Improving nisin production by encapsulated Lactococcus lactis with starch/carboxymethyl cellulose edible films.
33142614	6	56	theme	1.5	700:702	arg1	%					704:704	%	704:704	%	704:704	The composite film with 1.5 % L. lactis showed the highest release of nisin (3.35 mg/mL) and good antibacterial activity against Staphylococcus aureus (53.53 %) after 8 days.
33142614	0	57	with	lactis	55:60	arg1	films					105:109	starch/carboxymethyl cellulose edible films	67:109	starch/carboxymethyl cellulose edible films	67:109	Improving nisin production by encapsulated Lactococcus lactis with starch/carboxymethyl cellulose edible films.
33142614	3	58	theme	L.	396:397	arg1	lactis					399:404	L. lactis	396:404	L. lactis	396:404	Scanning electron microscopy images clearly showed that L. lactis was effectively embedded.
33142614	0	59	theme	starch/carboxymethyl	67:86	arg1	films					105:109	starch/carboxymethyl cellulose edible films	67:109	starch/carboxymethyl cellulose edible films	67:109	Improving nisin production by encapsulated Lactococcus lactis with starch/carboxymethyl cellulose edible films.
33142614	4	60	theme	%	450:450	arg1	lactis					455:460	1.5 % L. lactis	446:460	1.5 % L. lactis	446:460	The film with 1.5 % L. lactis showed the best performance and the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.
33142614	4	61	with	film	436:439	arg1	lactis					455:460	1.5 % L. lactis	446:460	1.5 % L. lactis	446:460	The film with 1.5 % L. lactis showed the best performance and the lowest water vapor transmission rate (5.54 × 10-11 g/m s Pa.
33524562	8	0	theme	infections	1729:1738	arg1	treatment					1708:1716	the treatment	1704:1716	the treatment of topical infections, including severe and hard-to-heal chronic wounds	1704:1788	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	3	1	theme	confocal	532:539	arg1	microscopy					554:563	confocal fluorescence microscopy	532:563	confocal fluorescence microscopy	532:563	This composite biomaterial was in-depth characterized by Gram stain, scanning electron microscopy (SEM) and confocal fluorescence microscopy.
33524562	4	2	theme	cellulose	639:647	arg1	nanofibers					649:658	cellulose nanofibers	639:658	cellulose nanofibers	639:658	Results demonstrated that probiotic cellulose consists of dense films of cellulose nanofibers, free of cellulose-producing bacteria, completely invaded by live probiotics (Lactobacillus fermentum or Lactobacillus gasseri).
33524562	6	3	theme	skin	1350:1353	arg1	infections					1355:1364	severe skin infections	1343:1364	severe skin infections	1343:1364	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	7	4	theme	probiotic	1396:1404	arg1	cellulose					1406:1414	probiotic cellulose	1396:1414	probiotic cellulose	1396:1414	Likewise, probiotic cellulose was also found to be effective to inhibit the proliferation of methicillin-resistant SA (MRSA).
33524562	7	5	theme	SA	1501:1502	arg1	proliferation					1462:1474	the proliferation	1458:1474	the proliferation of methicillin-resistant SA (MRSA)	1458:1509	Likewise, probiotic cellulose was also found to be effective to inhibit the proliferation of methicillin-resistant SA (MRSA).
33524562	6	6	theme	active	1323:1328	arg1	aureus					1269:1274	Staphylococcus aureus	1254:1274	Staphylococcus aureus (SA)	1254:1279	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	6	6	theme	active	1323:1328	arg1	pathogens					1330:1338	the most active pathogens	1314:1338	the most active pathogens	1314:1338	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	4	7	theme	bacteria	689:696	arg1	free					661:664	free	661:664	free	661:664	Results demonstrated that probiotic cellulose consists of dense films of cellulose nanofibers, free of cellulose-producing bacteria, completely invaded by live probiotics (Lactobacillus fermentum or Lactobacillus gasseri).
33524562	8	8	theme	topical	1721:1727	arg1	infections					1729:1738	topical infections	1721:1738	topical infections	1721:1738	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	8	8	theme	topical	1721:1727	arg1	wounds					1783:1788	severe and hard-to-heal chronic wounds	1751:1788	severe and hard-to-heal chronic wounds	1751:1788	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	8	9	theme	probiotics	1633:1642	arg1	combination					1516:1526	The combination	1512:1526	The combination of the properties of bacterial cellulose as wound dressing biomaterial	1512:1597	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	8	9	theme	probiotics	1633:1642	arg1	activity					1621:1628	the antibacterial activity	1603:1628	the antibacterial activity of probiotics	1603:1642	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	6	10	theme	Antibacterial	1100:1112	arg1	scenario					1172:1179	a real-life infection scenario	1150:1179	a real-life infection scenario	1150:1179	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	6	10	theme	Antibacterial	1100:1112	arg1	assays					1114:1119	Antibacterial assays	1100:1119	Antibacterial assays in pathogen-favorable media	1100:1147	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	9	11	theme	synthetic	1850:1858	arg1	approach					1860:1867	a one-pot synthetic approach	1840:1867	a one-pot synthetic approach	1840:1867	In addition, probiotic cellulose was obtained by a one-pot synthetic approach under mild conditions, not requiring the long and expensive chemical treatments to purify the genuine bacterial cellulose.
33524562	8	12	theme	cellulose	1559:1567	arg1	properties					1535:1544	the properties	1531:1544	the properties of bacterial cellulose as wound dressing biomaterial	1531:1597	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	6	13	theme	aeruginosa	1297:1306	arg1	viability					1241:1249	the viability	1237:1249	the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens	1237:1338	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	1	14	theme	bacterial	179:187	arg1	infections					189:198	bacterial infections	179:198	bacterial infections	179:198	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	9	15	theme	probiotic	1804:1812	arg1	cellulose					1814:1822	probiotic cellulose	1804:1822	probiotic cellulose	1804:1822	In addition, probiotic cellulose was obtained by a one-pot synthetic approach under mild conditions, not requiring the long and expensive chemical treatments to purify the genuine bacterial cellulose.
33524562	8	16	theme	wound	1572:1576	arg1	biomaterial					1587:1597	wound dressing biomaterial	1572:1597	wound dressing biomaterial	1572:1597	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	1	17	dep	increase	101:108	arg1	causing					144:150	causing	144:150	causing conventional treatments of bacterial infections to become increasingly inefficient	144:233	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	5	18	theme	pH	835:836	arg1	evolution					822:830	time evolution	817:830	time evolution of pH and reducing capacity against electrochromic polyoxometalate	817:897	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	6	19	from	assays	1114:1119	arg1	media					1143:1147	pathogen-favorable media	1124:1147	pathogen-favorable media	1124:1147	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	1	20	theme	alarming	92:99	arg1	one					239:241	one	239:241	one	239:241	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	1	20	theme	alarming	92:99	arg1	threats					258:264	the biggest threats	246:264	the biggest threats to global health	246:281	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	1	20	theme	alarming	92:99	arg1	increase					101:108	The alarming increase	88:108	The alarming increase	88:108	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	6	21	theme	infection	1162:1170	arg1	assays					1114:1119	Antibacterial assays	1100:1119	Antibacterial assays in pathogen-favorable media	1100:1147	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	6	21	theme	infection	1162:1170	arg1	scenario					1172:1179	a real-life infection scenario	1150:1179	a real-life infection scenario	1150:1179	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	2	22	theme	chronic	408:414	arg1	wounds					416:421	chronic wounds	408:421	chronic wounds	408:421	Here, we have developed probiotic cellulose, an antibiotic-free biomaterial for the treatment of severe skin infections and chronic wounds.
33524562	0	23	theme	Probiotic	0:8	arg1	cellulose					10:18	Probiotic cellulose	0:18	Probiotic cellulose: Antibiotic-free biomaterials with enhanced antibacterial activity.	0:86	Probiotic cellulose: Antibiotic-free biomaterials with enhanced antibacterial activity.
33524562	4	24	theme	probiotic	592:600	arg1	cellulose					602:610	probiotic cellulose	592:610	probiotic cellulose	592:610	Results demonstrated that probiotic cellulose consists of dense films of cellulose nanofibers, free of cellulose-producing bacteria, completely invaded by live probiotics (Lactobacillus fermentum or Lactobacillus gasseri).
33524562	3	25	theme	scanning	493:500	arg1	SEM					523:525	SEM	523:525	SEM	523:525	This composite biomaterial was in-depth characterized by Gram stain, scanning electron microscopy (SEM) and confocal fluorescence microscopy.
33524562	3	25	theme	scanning	493:500	arg1	microscopy					511:520	scanning electron microscopy	493:520	scanning electron microscopy (SEM)	493:526	This composite biomaterial was in-depth characterized by Gram stain, scanning electron microscopy (SEM) and confocal fluorescence microscopy.
33524562	1	26	theme	bacteria	134:141	arg1	one					239:241	one	239:241	one	239:241	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	1	26	theme	bacteria	134:141	arg1	threats					258:264	the biggest threats	246:264	the biggest threats to global health	246:281	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	1	26	theme	bacteria	134:141	arg1	increase					101:108	The alarming increase	88:108	The alarming increase	88:108	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	9	27	theme	chemical	1929:1936	arg1	treatments					1938:1947	the long and expensive chemical treatments	1906:1947	the long and expensive chemical treatments	1906:1947	In addition, probiotic cellulose was obtained by a one-pot synthetic approach under mild conditions, not requiring the long and expensive chemical treatments to purify the genuine bacterial cellulose.
33524562	8	28	theme	probiotic	1650:1658	arg1	cellulose					1660:1668	probiotic cellulose	1650:1668	probiotic cellulose	1650:1668	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	5	29	theme	reducing	842:849	arg1	capacity					851:858	reducing capacity	842:858	reducing capacity	842:858	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	0	30	theme	enhanced	55:62	arg1	activity					78:85	enhanced antibacterial activity	55:85	enhanced antibacterial activity	55:85	Probiotic cellulose: Antibiotic-free biomaterials with enhanced antibacterial activity.
33524562	8	31	theme	severe	1751:1756	arg1	wounds					1783:1788	severe and hard-to-heal chronic wounds	1751:1788	severe and hard-to-heal chronic wounds	1751:1788	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	1	32	theme	biggest	250:256	arg1	threats					258:264	the biggest threats	246:264	the biggest threats to global health	246:281	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	9	33	theme	bacterial	1971:1979	arg1	cellulose					1981:1989	the genuine bacterial cellulose	1959:1989	the genuine bacterial cellulose	1959:1989	In addition, probiotic cellulose was obtained by a one-pot synthetic approach under mild conditions, not requiring the long and expensive chemical treatments to purify the genuine bacterial cellulose.
33524562	4	34	theme	nanofibers	649:658	arg1	films					630:634	dense films	624:634	dense films of cellulose nanofibers, free of cellulose-producing bacteria, completely invaded by live probiotics (Lactobacillus fermentum or Lactobacillus gasseri)	624:786	Results demonstrated that probiotic cellulose consists of dense films of cellulose nanofibers, free of cellulose-producing bacteria, completely invaded by live probiotics (Lactobacillus fermentum or Lactobacillus gasseri).
33524562	3	35	theme	fluorescence	541:552	arg1	microscopy					554:563	confocal fluorescence microscopy	532:563	confocal fluorescence microscopy	532:563	This composite biomaterial was in-depth characterized by Gram stain, scanning electron microscopy (SEM) and confocal fluorescence microscopy.
33524562	8	36	theme	hard-to-heal	1762:1773	arg1	wounds					1783:1788	severe and hard-to-heal chronic wounds	1751:1788	severe and hard-to-heal chronic wounds	1751:1788	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	5	37	theme	capacity	851:858	arg1	evolution					822:830	time evolution	817:830	time evolution of pH and reducing capacity against electrochromic polyoxometalate	817:897	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	5	38	theme	antibacterial	1073:1085	arg1	biomaterial					1087:1097	an antibiotic-free antibacterial biomaterial	1054:1097	an antibiotic-free antibacterial biomaterial	1054:1097	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	4	39	theme	free	661:664	arg1	nanofibers					649:658	cellulose nanofibers	639:658	cellulose nanofibers	639:658	Results demonstrated that probiotic cellulose consists of dense films of cellulose nanofibers, free of cellulose-producing bacteria, completely invaded by live probiotics (Lactobacillus fermentum or Lactobacillus gasseri).
33524562	6	40	theme	chronic	1370:1376	arg1	wounds					1378:1383	chronic wounds	1370:1383	chronic wounds	1370:1383	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	0	41	with	biomaterials	37:48	arg1	activity					78:85	enhanced antibacterial activity	55:85	enhanced antibacterial activity	55:85	Probiotic cellulose: Antibiotic-free biomaterials with enhanced antibacterial activity.
33524562	2	42	theme	severe	381:386	arg1	infections					393:402	severe skin infections	381:402	severe skin infections	381:402	Here, we have developed probiotic cellulose, an antibiotic-free biomaterial for the treatment of severe skin infections and chronic wounds.
33524562	4	43	theme	dense	624:628	arg1	films					630:634	dense films	624:634	dense films of cellulose nanofibers, free of cellulose-producing bacteria, completely invaded by live probiotics (Lactobacillus fermentum or Lactobacillus gasseri)	624:786	Results demonstrated that probiotic cellulose consists of dense films of cellulose nanofibers, free of cellulose-producing bacteria, completely invaded by live probiotics (Lactobacillus fermentum or Lactobacillus gasseri).
33524562	2	44	theme	probiotic	308:316	arg1	biomaterial					348:358	an antibiotic-free biomaterial	329:358	an antibiotic-free biomaterial for the treatment of severe skin infections and chronic wounds	329:421	Here, we have developed probiotic cellulose, an antibiotic-free biomaterial for the treatment of severe skin infections and chronic wounds.
33524562	2	44	theme	probiotic	308:316	arg1	cellulose					318:326	probiotic cellulose	308:326	probiotic cellulose	308:326	Here, we have developed probiotic cellulose, an antibiotic-free biomaterial for the treatment of severe skin infections and chronic wounds.
33524562	6	45	theme	aureus	1269:1274	arg1	viability					1241:1249	the viability	1237:1249	the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens	1237:1338	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	6	46	theme	severe	1343:1348	arg1	infections					1355:1364	severe skin infections	1343:1364	severe skin infections	1343:1364	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	5	47	theme	cellulose	937:945	arg1	matrix					947:952	the cellulose matrix	933:952	the cellulose matrix	933:952	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	2	48	theme	antibiotic-free	332:346	arg1	biomaterial					348:358	an antibiotic-free biomaterial	329:358	an antibiotic-free biomaterial for the treatment of severe skin infections and chronic wounds	329:421	Here, we have developed probiotic cellulose, an antibiotic-free biomaterial for the treatment of severe skin infections and chronic wounds.
33524562	2	48	theme	antibiotic-free	332:346	arg1	cellulose					318:326	probiotic cellulose	308:326	probiotic cellulose	308:326	Here, we have developed probiotic cellulose, an antibiotic-free biomaterial for the treatment of severe skin infections and chronic wounds.
33524562	4	49	theme	live	721:724	arg1	probiotics					726:735	live probiotics	721:735	live probiotics (Lactobacillus fermentum or Lactobacillus gasseri)	721:786	Results demonstrated that probiotic cellulose consists of dense films of cellulose nanofibers, free of cellulose-producing bacteria, completely invaded by live probiotics (Lactobacillus fermentum or Lactobacillus gasseri).
33524562	2	50	theme	infections	393:402	arg1	treatment					368:376	the treatment	364:376	the treatment of severe skin infections and chronic wounds	364:421	Here, we have developed probiotic cellulose, an antibiotic-free biomaterial for the treatment of severe skin infections and chronic wounds.
33524562	7	51	theme	methicillin-resistant	1479:1499	arg1	SA					1501:1502	methicillin-resistant SA	1479:1502	methicillin-resistant SA (MRSA)	1479:1509	Likewise, probiotic cellulose was also found to be effective to inhibit the proliferation of methicillin-resistant SA (MRSA).
33524562	7	51	theme	methicillin-resistant	1479:1499	arg1	MRSA					1505:1508	MRSA	1505:1508	MRSA	1505:1508	Likewise, probiotic cellulose was also found to be effective to inhibit the proliferation of methicillin-resistant SA (MRSA).
33524562	4	52	theme	cellulose-producing	669:687	arg1	bacteria					689:696	cellulose-producing bacteria	669:696	cellulose-producing bacteria	669:696	Results demonstrated that probiotic cellulose consists of dense films of cellulose nanofibers, free of cellulose-producing bacteria, completely invaded by live probiotics (Lactobacillus fermentum or Lactobacillus gasseri).
33524562	8	53	theme	properties	1535:1544	arg1	combination					1516:1526	The combination	1512:1526	The combination of the properties of bacterial cellulose as wound dressing biomaterial	1512:1597	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	8	53	theme	properties	1535:1544	arg1	activity					1621:1628	the antibacterial activity	1603:1628	the antibacterial activity of probiotics	1603:1642	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	8	54	theme	bacterial	1549:1557	arg1	cellulose					1559:1567	bacterial cellulose	1549:1567	bacterial cellulose as wound dressing biomaterial	1549:1597	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	1	55	theme	conventional	152:163	arg1	treatments					165:174	conventional treatments	152:174	conventional treatments of bacterial infections	152:198	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	9	56	theme	one-pot	1842:1848	arg1	approach					1860:1867	a one-pot synthetic approach	1840:1867	a one-pot synthetic approach	1840:1867	In addition, probiotic cellulose was obtained by a one-pot synthetic approach under mild conditions, not requiring the long and expensive chemical treatments to purify the genuine bacterial cellulose.
33524562	5	57	theme	time	817:820	arg1	evolution					822:830	time evolution	817:830	time evolution of pH and reducing capacity against electrochromic polyoxometalate	817:897	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	8	58	theme	dressing	1578:1585	arg1	biomaterial					1587:1597	wound dressing biomaterial	1572:1597	wound dressing biomaterial	1572:1597	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	1	59	theme	infections	189:198	arg1	treatments					165:174	conventional treatments	152:174	conventional treatments of bacterial infections	152:198	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	9	60	theme	mild	1875:1878	arg1	conditions					1880:1889	mild conditions	1875:1889	mild conditions	1875:1889	In addition, probiotic cellulose was obtained by a one-pot synthetic approach under mild conditions, not requiring the long and expensive chemical treatments to purify the genuine bacterial cellulose.
33524562	5	61	theme	Viability	789:797	arg1	evolution					822:830	time evolution	817:830	time evolution of pH and reducing capacity against electrochromic polyoxometalate	817:897	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	5	61	theme	Viability	789:797	arg1	assays					799:804	Viability assays	789:804	Viability assays	789:804	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	8	62	theme	antibacterial	1607:1619	arg1	activity					1621:1628	the antibacterial activity	1603:1628	the antibacterial activity of probiotics	1603:1642	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	5	63	theme	probiotic	1031:1039	arg1	cellulose					1041:1049	probiotic cellulose	1031:1049	probiotic cellulose	1031:1049	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	2	64	theme	wounds	416:421	arg1	treatment					368:376	the treatment	364:376	the treatment of severe skin infections and chronic wounds	364:421	Here, we have developed probiotic cellulose, an antibiotic-free biomaterial for the treatment of severe skin infections and chronic wounds.
33524562	5	65	theme	electrochromic	868:881	arg1	polyoxometalate					883:897	electrochromic polyoxometalate	868:897	electrochromic polyoxometalate	868:897	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	5	66	theme	key	1006:1008	arg1	point					1010:1014	a key point	1004:1014	a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial	1004:1097	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	5	66	theme	key	1006:1008	arg1	probiotics					915:924	probiotics	915:924	probiotics within the cellulose matrix	915:952	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	6	67	theme	real-life	1152:1160	arg1	assays					1114:1119	Antibacterial assays	1100:1119	Antibacterial assays in pathogen-favorable media	1100:1147	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	6	67	theme	real-life	1152:1160	arg1	scenario					1172:1179	a real-life infection scenario	1150:1179	a real-life infection scenario	1150:1179	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	9	68	theme	long	1910:1913	arg1	treatments					1938:1947	the long and expensive chemical treatments	1906:1947	the long and expensive chemical treatments	1906:1947	In addition, probiotic cellulose was obtained by a one-pot synthetic approach under mild conditions, not requiring the long and expensive chemical treatments to purify the genuine bacterial cellulose.
33524562	0	69	theme	Antibiotic-free	21:35	arg1	biomaterials					37:48	Antibiotic-free biomaterials	21:48	Probiotic cellulose: Antibiotic-free biomaterials with enhanced antibacterial activity.	0:86	Probiotic cellulose: Antibiotic-free biomaterials with enhanced antibacterial activity.
33524562	0	70	dep	cellulose	10:18	arg1	biomaterials					37:48	Antibiotic-free biomaterials	21:48	Probiotic cellulose: Antibiotic-free biomaterials with enhanced antibacterial activity.	0:86	Probiotic cellulose: Antibiotic-free biomaterials with enhanced antibacterial activity.
33524562	1	71	theme	antibiotic-resistant	113:132	arg1	bacteria					134:141	antibiotic-resistant bacteria	113:141	antibiotic-resistant bacteria	113:141	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	9	72	theme	expensive	1919:1927	arg1	treatments					1938:1947	the long and expensive chemical treatments	1906:1947	the long and expensive chemical treatments	1906:1947	In addition, probiotic cellulose was obtained by a one-pot synthetic approach under mild conditions, not requiring the long and expensive chemical treatments to purify the genuine bacterial cellulose.
33524562	5	73	dep	alive	967:971	arg1	point					1010:1014	a key point	1004:1014	a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial	1004:1097	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	5	73	dep	alive	967:971	arg1	probiotics					915:924	probiotics	915:924	probiotics within the cellulose matrix	915:952	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	3	74	theme	electron	502:509	arg1	SEM					523:525	SEM	523:525	SEM	523:525	This composite biomaterial was in-depth characterized by Gram stain, scanning electron microscopy (SEM) and confocal fluorescence microscopy.
33524562	3	74	theme	electron	502:509	arg1	microscopy					511:520	scanning electron microscopy	493:520	scanning electron microscopy (SEM)	493:526	This composite biomaterial was in-depth characterized by Gram stain, scanning electron microscopy (SEM) and confocal fluorescence microscopy.
33524562	3	75	dep	in-depth	455:462	arg1	characterized					464:476	characterized	464:476	characterized by Gram stain, scanning electron microscopy (SEM) and confocal fluorescence microscopy	464:563	This composite biomaterial was in-depth characterized by Gram stain, scanning electron microscopy (SEM) and confocal fluorescence microscopy.
33524562	6	76	theme	pathogen-favorable	1124:1141	arg1	media					1143:1147	pathogen-favorable media	1124:1147	pathogen-favorable media	1124:1147	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	0	77	theme	antibacterial	64:76	arg1	activity					78:85	enhanced antibacterial activity	55:85	enhanced antibacterial activity	55:85	Probiotic cellulose: Antibiotic-free biomaterials with enhanced antibacterial activity.
33524562	3	78	theme	composite	429:437	arg1	biomaterial					439:449	This composite biomaterial	424:449	This composite biomaterial	424:449	This composite biomaterial was in-depth characterized by Gram stain, scanning electron microscopy (SEM) and confocal fluorescence microscopy.
33524562	9	79	theme	genuine	1963:1969	arg1	cellulose					1981:1989	the genuine bacterial cellulose	1959:1989	the genuine bacterial cellulose	1959:1989	In addition, probiotic cellulose was obtained by a one-pot synthetic approach under mild conditions, not requiring the long and expensive chemical treatments to purify the genuine bacterial cellulose.
33524562	5	80	theme	cellulose	1041:1049	arg1	use					1024:1026	the use	1020:1026	the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial	1020:1097	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	8	81	theme	chronic	1775:1781	arg1	wounds					1783:1788	severe and hard-to-heal chronic wounds	1751:1788	severe and hard-to-heal chronic wounds	1751:1788	The combination of the properties of bacterial cellulose as wound dressing biomaterial and the antibacterial activity of probiotics makes probiotic cellulose an alternative to antibiotics for the treatment of topical infections, including severe and hard-to-heal chronic wounds.
33524562	1	82	theme	threats	258:264	arg1	one					239:241	one	239:241	one	239:241	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	1	82	theme	threats	258:264	arg1	threats					258:264	the biggest threats	246:264	the biggest threats to global health	246:281	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	1	82	theme	threats	258:264	arg1	increase					101:108	The alarming increase	88:108	The alarming increase	88:108	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
33524562	5	83	theme	antibiotic-free	1057:1071	arg1	biomaterial					1087:1097	an antibiotic-free antibacterial biomaterial	1054:1097	an antibiotic-free antibacterial biomaterial	1054:1097	Viability assays, including time evolution of pH and reducing capacity against electrochromic polyoxometalate, confirmed that probiotics within the cellulose matrix are not only alive but also metabolically active, a key point for the use of probiotic cellulose as an antibiotic-free antibacterial biomaterial.
33524562	6	84	theme	probiotic	1200:1208	arg1	cellulose					1210:1218	probiotic cellulose	1200:1218	probiotic cellulose	1200:1218	Antibacterial assays in pathogen-favorable media, a real-life infection scenario, demonstrated that probiotic cellulose strongly reduces the viability of Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the most active pathogens in severe skin infections and chronic wounds.
33524562	3	85	theme	Gram	481:484	arg1	stain					486:490	Gram stain	481:490	Gram stain	481:490	This composite biomaterial was in-depth characterized by Gram stain, scanning electron microscopy (SEM) and confocal fluorescence microscopy.
33524562	2	86	theme	skin	388:391	arg1	infections					393:402	severe skin infections	381:402	severe skin infections	381:402	Here, we have developed probiotic cellulose, an antibiotic-free biomaterial for the treatment of severe skin infections and chronic wounds.
33524562	1	87	theme	global	269:274	arg1	health					276:281	global health	269:281	global health	269:281	The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health.
32959246	1	0	gly	glycoproteins	193:205	arg1	glycoproteins					193:205	glycoproteins	193:205	glycoproteins	193:205	The outermost surface of bacterial pathogens consists primarily of complex carbohydrate structures-polysaccharides, glycolipids, and glycoproteins.
32959246	6	1	theme	causative	981:989	arg1	pleuropneumoniae					959:974	Actinobacillus pleuropneumoniae	944:974	Actinobacillus pleuropneumoniae	944:974	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	6	1	theme	causative	981:989	arg1	agent					991:995	the causative agent	977:995	the causative agent of porcine pleuropneumoniae	977:1023	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	5	2	from	developments	676:687	arg1	field					696:700	the field	692:700	the field of bacterial glycoengineering	692:730	Recent developments in the field of bacterial glycoengineering have opened the opportunity for total recombinant production of glycoconjugate vaccines.
32959246	0	3	theme	Glycoconjugate	16:29	arg1	VLPs					53:56	VLPs	53:56	VLPs	53:56	Biosynthesis of Glycoconjugate Virus-like Particles (VLPs).
32959246	0	3	theme	Glycoconjugate	16:29	arg1	Particles					42:50	Glycoconjugate Virus-like Particles	16:50	Glycoconjugate Virus-like Particles (VLPs)	16:57	Biosynthesis of Glycoconjugate Virus-like Particles (VLPs).
32959246	4	4	theme	immunogenic	648:658	arg1	protein					660:666	an immunogenic protein	645:666	an immunogenic protein	645:666	Thus, the carbohydrate antigen is typically purified from the pathogen and then chemically conjugated to an immunogenic protein.
32959246	6	5	theme	pleuropneumoniae	1008:1023	arg1	pleuropneumoniae					959:974	Actinobacillus pleuropneumoniae	944:974	Actinobacillus pleuropneumoniae	944:974	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	6	5	theme	pleuropneumoniae	1008:1023	arg1	agent					991:995	the causative agent	977:995	the causative agent of porcine pleuropneumoniae	977:1023	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	6	6	theme	porcine	1000:1006	arg1	pleuropneumoniae					1008:1023	porcine pleuropneumoniae	1000:1023	porcine pleuropneumoniae	1000:1023	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	2	7	theme	covalent	316:323	arg1	attachment					325:334	covalent attachment	316:334	covalent attachment to an immunogenic carrier protein-a so-called glycoconjugate vaccine	316:403	To raise a long-lasting and effective immune response against carbohydrate antigens, they generally require covalent attachment to an immunogenic carrier protein-a so-called glycoconjugate vaccine.
32959246	2	8	theme	protein-a	362:370	arg1	vaccine					397:403	an immunogenic carrier protein-a so-called glycoconjugate vaccine	339:403	an immunogenic carrier protein-a so-called glycoconjugate vaccine	339:403	To raise a long-lasting and effective immune response against carbohydrate antigens, they generally require covalent attachment to an immunogenic carrier protein-a so-called glycoconjugate vaccine.
32959246	1	9	theme	outermost	64:72	arg1	surface					74:80	The outermost surface	60:80	The outermost surface of bacterial pathogens	60:103	The outermost surface of bacterial pathogens consists primarily of complex carbohydrate structures-polysaccharides, glycolipids, and glycoproteins.
32959246	5	10	theme	bacterial	705:713	arg1	glycoengineering					715:730	bacterial glycoengineering	705:730	bacterial glycoengineering	705:730	Recent developments in the field of bacterial glycoengineering have opened the opportunity for total recombinant production of glycoconjugate vaccines.
32959246	4	11	theme	carbohydrate	550:561	arg1	antigen					563:569	the carbohydrate antigen	546:569	the carbohydrate antigen	546:569	Thus, the carbohydrate antigen is typically purified from the pathogen and then chemically conjugated to an immunogenic protein.
32959246	5	12	theme	glycoengineering	715:730	arg1	field					696:700	the field	692:700	the field of bacterial glycoengineering	692:730	Recent developments in the field of bacterial glycoengineering have opened the opportunity for total recombinant production of glycoconjugate vaccines.
32959246	6	13	theme	virus-like	882:891	arg1	VLPs					904:907	VLPs	904:907	VLPs	904:907	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	6	13	theme	virus-like	882:891	arg1	particles					893:901	virus-like particles	882:901	virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae	882:1023	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	6	13	theme	virus-like	882:891	arg1	production					853:862	the production	849:862	the production of proteinaceous	849:879	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	2	14	theme	carrier	354:360	arg1	protein-a					362:370	an immunogenic carrier protein-a	339:370	an immunogenic carrier protein-a so-called glycoconjugate vaccine	339:403	To raise a long-lasting and effective immune response against carbohydrate antigens, they generally require covalent attachment to an immunogenic carrier protein-a so-called glycoconjugate vaccine.
32959246	3	15	theme	glycoconjugate	439:452	arg1	vaccines					454:461	glycoconjugate vaccines	439:461	glycoconjugate vaccines	439:461	One hurdle to the development of glycoconjugate vaccines is that carbohydrate antigens remain inaccessible to recombinant production.
32959246	2	16	theme	immunogenic	342:352	arg1	protein-a					362:370	an immunogenic carrier protein-a	339:370	an immunogenic carrier protein-a so-called glycoconjugate vaccine	339:403	To raise a long-lasting and effective immune response against carbohydrate antigens, they generally require covalent attachment to an immunogenic carrier protein-a so-called glycoconjugate vaccine.
32959246	0	17	theme	Virus-like	31:40	arg1	VLPs					53:56	VLPs	53:56	VLPs	53:56	Biosynthesis of Glycoconjugate Virus-like Particles (VLPs).
32959246	0	17	theme	Virus-like	31:40	arg1	Particles					42:50	Glycoconjugate Virus-like Particles	16:50	Glycoconjugate Virus-like Particles (VLPs)	16:57	Biosynthesis of Glycoconjugate Virus-like Particles (VLPs).
32959246	5	18	theme	glycoconjugate	796:809	arg1	vaccines					811:818	glycoconjugate vaccines	796:818	glycoconjugate vaccines	796:818	Recent developments in the field of bacterial glycoengineering have opened the opportunity for total recombinant production of glycoconjugate vaccines.
32959246	5	19	theme	Recent	669:674	arg1	developments					676:687	Recent developments	669:687	Recent developments in the field of bacterial glycoengineering	669:730	Recent developments in the field of bacterial glycoengineering have opened the opportunity for total recombinant production of glycoconjugate vaccines.
32959246	1	20	theme	pathogens	95:103	arg1	surface					74:80	The outermost surface	60:80	The outermost surface of bacterial pathogens	60:103	The outermost surface of bacterial pathogens consists primarily of complex carbohydrate structures-polysaccharides, glycolipids, and glycoproteins.
32959246	1	21	theme	bacterial	85:93	arg1	pathogens					95:103	bacterial pathogens	85:103	bacterial pathogens	85:103	The outermost surface of bacterial pathogens consists primarily of complex carbohydrate structures-polysaccharides, glycolipids, and glycoproteins.
32959246	5	22	theme	vaccines	811:818	arg1	production					782:791	total recombinant production	764:791	total recombinant production of glycoconjugate vaccines	764:818	Recent developments in the field of bacterial glycoengineering have opened the opportunity for total recombinant production of glycoconjugate vaccines.
32959246	3	23	theme	recombinant	516:526	arg1	production					528:537	recombinant production	516:537	recombinant production	516:537	One hurdle to the development of glycoconjugate vaccines is that carbohydrate antigens remain inaccessible to recombinant production.
32959246	0	24	theme	Particles	42:50	arg1	Biosynthesis					0:11	Biosynthesis	0:11	Biosynthesis of Glycoconjugate Virus-like Particles (VLPs)	0:57	Biosynthesis of Glycoconjugate Virus-like Particles (VLPs).
32959246	3	25	theme	carbohydrate	471:482	arg1	antigens					484:491	carbohydrate antigens	471:491	carbohydrate antigens	471:491	One hurdle to the development of glycoconjugate vaccines is that carbohydrate antigens remain inaccessible to recombinant production.
32959246	6	26	theme	pleuropneumoniae	959:974	arg1	N-glycan					932:939	the conserved N-glycan	918:939	the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae	918:1023	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	3	27	theme	vaccines	454:461	arg1	development					424:434	the development	420:434	the development of glycoconjugate vaccines	420:461	One hurdle to the development of glycoconjugate vaccines is that carbohydrate antigens remain inaccessible to recombinant production.
32959246	5	28	theme	total	764:768	arg1	production					782:791	total recombinant production	764:791	total recombinant production of glycoconjugate vaccines	764:818	Recent developments in the field of bacterial glycoengineering have opened the opportunity for total recombinant production of glycoconjugate vaccines.
32959246	6	29	theme	Actinobacillus	944:957	arg1	pleuropneumoniae					959:974	Actinobacillus pleuropneumoniae	944:974	Actinobacillus pleuropneumoniae	944:974	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	6	29	theme	Actinobacillus	944:957	arg1	agent					991:995	the causative agent	977:995	the causative agent of porcine pleuropneumoniae	977:1023	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	2	30	theme	immune	246:251	arg1	response					253:260	a long-lasting and effective immune response	217:260	a long-lasting and effective immune response against carbohydrate antigens	217:290	To raise a long-lasting and effective immune response against carbohydrate antigens, they generally require covalent attachment to an immunogenic carrier protein-a so-called glycoconjugate vaccine.
32959246	5	31	theme	recombinant	770:780	arg1	production					782:791	total recombinant production	764:791	total recombinant production of glycoconjugate vaccines	764:818	Recent developments in the field of bacterial glycoengineering have opened the opportunity for total recombinant production of glycoconjugate vaccines.
32959246	2	32	theme	effective	236:244	arg1	response					253:260	a long-lasting and effective immune response	217:260	a long-lasting and effective immune response against carbohydrate antigens	217:290	To raise a long-lasting and effective immune response against carbohydrate antigens, they generally require covalent attachment to an immunogenic carrier protein-a so-called glycoconjugate vaccine.
32959246	2	33	theme	glycoconjugate	382:395	arg1	vaccine					397:403	an immunogenic carrier protein-a so-called glycoconjugate vaccine	339:403	an immunogenic carrier protein-a so-called glycoconjugate vaccine	339:403	To raise a long-lasting and effective immune response against carbohydrate antigens, they generally require covalent attachment to an immunogenic carrier protein-a so-called glycoconjugate vaccine.
32959246	6	34	theme	proteinaceous	867:879	arg1	particles					893:901	virus-like particles	882:901	virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae	882:1023	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	6	34	theme	proteinaceous	867:879	arg1	production					853:862	the production	849:862	the production of proteinaceous	849:879	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	2	35	theme	long-lasting	219:230	arg1	response					253:260	a long-lasting and effective immune response	217:260	a long-lasting and effective immune response against carbohydrate antigens	217:290	To raise a long-lasting and effective immune response against carbohydrate antigens, they generally require covalent attachment to an immunogenic carrier protein-a so-called glycoconjugate vaccine.
32959246	1	36	theme	complex	127:133	arg1	structures-polysaccharides					148:173	complex carbohydrate structures-polysaccharides	127:173	complex carbohydrate structures-polysaccharides	127:173	The outermost surface of bacterial pathogens consists primarily of complex carbohydrate structures-polysaccharides, glycolipids, and glycoproteins.
32959246	6	37	theme	conserved	922:930	arg1	N-glycan					932:939	the conserved N-glycan	918:939	the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae	918:1023	In this method, we describe the production of proteinaceous, virus-like particles (VLPs) bearing the conserved N-glycan of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumoniae.
32959246	1	38	theme	carbohydrate	135:146	arg1	structures-polysaccharides					148:173	complex carbohydrate structures-polysaccharides	127:173	complex carbohydrate structures-polysaccharides	127:173	The outermost surface of bacterial pathogens consists primarily of complex carbohydrate structures-polysaccharides, glycolipids, and glycoproteins.
32959246	2	39	theme	so-called	372:380	arg1	vaccine					397:403	an immunogenic carrier protein-a so-called glycoconjugate vaccine	339:403	an immunogenic carrier protein-a so-called glycoconjugate vaccine	339:403	To raise a long-lasting and effective immune response against carbohydrate antigens, they generally require covalent attachment to an immunogenic carrier protein-a so-called glycoconjugate vaccine.
32959246	2	40	theme	carbohydrate	270:281	arg1	antigens					283:290	carbohydrate antigens	270:290	carbohydrate antigens	270:290	To raise a long-lasting and effective immune response against carbohydrate antigens, they generally require covalent attachment to an immunogenic carrier protein-a so-called glycoconjugate vaccine.
34893247	3	0	theme	significant	315:325	arg1	symptoms					340:347	significant inflammatory symptoms	315:347	significant inflammatory symptoms	315:347	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	5	1	theme	κ-CGN-fed	787:795	arg1	mice					797:800	germ-free κ-CGN-fed mice	777:800	germ-free κ-CGN-fed mice	777:800	Mucus layer degradation and altered SCFA levels could be reproduced by fecal transplantation from κ-CGN-fed mice, but not from germ-free κ-CGN-fed mice.
34893247	7	2	theme	probiotics	1151:1160	arg1	introduction					1135:1146	the introduction	1131:1146	the introduction of probiotics	1131:1160	Our results suggest that κ-CGN may not be directly inflammatory, but it creates an environment that favors inflammation by perturbation of gut microbiota composition and then facilitates expansion of pathogens, and this effect may be partially reversed by the introduction of probiotics.
34893247	7	3	theme	gut	1014:1016	arg1	composition					1029:1039	gut microbiota composition	1014:1039	gut microbiota composition	1014:1039	Our results suggest that κ-CGN may not be directly inflammatory, but it creates an environment that favors inflammation by perturbation of gut microbiota composition and then facilitates expansion of pathogens, and this effect may be partially reversed by the introduction of probiotics.
34893247	4	4	theme	mucosal	609:615	arg1	damage					617:622	mucosal damage	609:622	mucosal damage	609:622	Administration of the pathogenic bacterium Citrobacter rodentium, further aggravated the inflammation and mucosal damage in the presence of κ-CGN.
34893247	3	5	theme	inflammatory	327:338	arg1	symptoms					340:347	significant inflammatory symptoms	315:347	significant inflammatory symptoms	315:347	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	4	6	theme	pathogenic	525:534	arg1	rodentium					558:566	the pathogenic bacterium Citrobacter rodentium	521:566	the pathogenic bacterium Citrobacter rodentium	521:566	Administration of the pathogenic bacterium Citrobacter rodentium, further aggravated the inflammation and mucosal damage in the presence of κ-CGN.
34893247	5	7	theme	altered	678:684	arg1	levels					691:696	altered SCFA levels	678:696	altered SCFA levels	678:696	Mucus layer degradation and altered SCFA levels could be reproduced by fecal transplantation from κ-CGN-fed mice, but not from germ-free κ-CGN-fed mice.
34893247	5	8	theme	SCFA	686:689	arg1	levels					691:696	altered SCFA levels	678:696	altered SCFA levels	678:696	Mucus layer degradation and altered SCFA levels could be reproduced by fecal transplantation from κ-CGN-fed mice, but not from germ-free κ-CGN-fed mice.
34893247	4	9	from	damage	617:622	arg1	presence					631:638	the presence	627:638	the presence of κ-CGN	627:647	Administration of the pathogenic bacterium Citrobacter rodentium, further aggravated the inflammation and mucosal damage in the presence of κ-CGN.
34893247	1	10	theme	inflammatory	87:98	arg1	effects					100:106	The inflammatory effects	83:106	The inflammatory effects of carrageenan (CGN), a ubiquitous food additive,	83:156	The inflammatory effects of carrageenan (CGN), a ubiquitous food additive, remains controversial.
34893247	5	11	theme	Mucus	650:654	arg1	degradation					662:672	Mucus layer degradation	650:672	Mucus layer degradation	650:672	Mucus layer degradation and altered SCFA levels could be reproduced by fecal transplantation from κ-CGN-fed mice, but not from germ-free κ-CGN-fed mice.
34893247	0	12	theme	Dietary	0:6	arg1	κ-carrageenan					8:20	Dietary κ-carrageenan	0:20	Dietary κ-carrageenan	0:20	Dietary κ-carrageenan facilitates gut microbiota-mediated intestinal inflammation.
34893247	3	13	theme	short-chain	392:402	arg1	SCFAs					417:421	SCFAs	417:421	SCFAs	417:421	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	3	13	theme	short-chain	392:402	arg1	acids					410:414	reduced bacteria-derived short-chain fatty acids	367:414	reduced bacteria-derived short-chain fatty acids (SCFAs)	367:422	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	5	14	theme	layer	656:660	arg1	degradation					662:672	Mucus layer degradation	650:672	Mucus layer degradation	650:672	Mucus layer degradation and altered SCFA levels could be reproduced by fecal transplantation from κ-CGN-fed mice, but not from germ-free κ-CGN-fed mice.
34893247	1	15	theme	carrageenan	111:121	arg1	effects					100:106	The inflammatory effects	83:106	The inflammatory effects of carrageenan (CGN), a ubiquitous food additive,	83:156	The inflammatory effects of carrageenan (CGN), a ubiquitous food additive, remains controversial.
34893247	3	16	theme	fatty	404:408	arg1	SCFAs					417:421	SCFAs	417:421	SCFAs	417:421	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	3	16	theme	fatty	404:408	arg1	acids					410:414	reduced bacteria-derived short-chain fatty acids	367:414	reduced bacteria-derived short-chain fatty acids (SCFAs)	367:422	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	3	17	theme	reduced	367:373	arg1	SCFAs					417:421	SCFAs	417:421	SCFAs	417:421	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	3	17	theme	reduced	367:373	arg1	acids					410:414	reduced bacteria-derived short-chain fatty acids	367:414	reduced bacteria-derived short-chain fatty acids (SCFAs)	367:422	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	5	18	theme	fecal	721:725	arg1	transplantation					727:741	fecal transplantation	721:741	fecal transplantation from κ-CGN-fed mice, but not from germ-free κ-CGN-fed mice	721:800	Mucus layer degradation and altered SCFA levels could be reproduced by fecal transplantation from κ-CGN-fed mice, but not from germ-free κ-CGN-fed mice.
34893247	3	19	theme	layer	461:465	arg1	thickness					438:446	thickness	438:446	thickness of the mucus layer	438:465	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	3	20	theme	bacteria-derived	375:390	arg1	SCFAs					417:421	SCFAs	417:421	SCFAs	417:421	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	3	20	theme	bacteria-derived	375:390	arg1	acids					410:414	reduced bacteria-derived short-chain fatty acids	367:414	reduced bacteria-derived short-chain fatty acids (SCFAs)	367:422	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	0	21	theme	intestinal	58:67	arg1	inflammation					69:80	gut microbiota-mediated intestinal inflammation	34:80	gut microbiota-mediated intestinal inflammation	34:80	Dietary κ-carrageenan facilitates gut microbiota-mediated intestinal inflammation.
34893247	0	22	theme	microbiota-mediated	38:56	arg1	inflammation					69:80	gut microbiota-mediated intestinal inflammation	34:80	gut microbiota-mediated intestinal inflammation	34:80	Dietary κ-carrageenan facilitates gut microbiota-mediated intestinal inflammation.
34893247	4	23	theme	Citrobacter	546:556	arg1	rodentium					558:566	the pathogenic bacterium Citrobacter rodentium	521:566	the pathogenic bacterium Citrobacter rodentium	521:566	Administration of the pathogenic bacterium Citrobacter rodentium, further aggravated the inflammation and mucosal damage in the presence of κ-CGN.
34893247	5	24	theme	κ-CGN-fed	748:756	arg1	mice					758:761	κ-CGN-fed mice	748:761	κ-CGN-fed mice	748:761	Mucus layer degradation and altered SCFA levels could be reproduced by fecal transplantation from κ-CGN-fed mice, but not from germ-free κ-CGN-fed mice.
34893247	2	25	theme	Gut	181:183	arg1	microbiota					185:194	Gut microbiota	181:194	Gut microbiota	181:194	Gut microbiota and intestinal homeostasis may be a breakthrough in resolving this controversy.
34893247	2	25	theme	Gut	181:183	arg1	homeostasis					211:221	intestinal homeostasis	200:221	intestinal homeostasis	200:221	Gut microbiota and intestinal homeostasis may be a breakthrough in resolving this controversy.
34893247	2	25	theme	Gut	181:183	arg1	breakthrough					232:243	a breakthrough	230:243	a breakthrough	230:243	Gut microbiota and intestinal homeostasis may be a breakthrough in resolving this controversy.
34893247	0	26	theme	gut	34:36	arg1	inflammation					69:80	gut microbiota-mediated intestinal inflammation	34:80	gut microbiota-mediated intestinal inflammation	34:80	Dietary κ-carrageenan facilitates gut microbiota-mediated intestinal inflammation.
34893247	3	27	theme	mucus	455:459	arg1	layer					461:465	the mucus layer	451:465	the mucus layer	451:465	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	4	28	theme	bacterium	536:544	arg1	rodentium					558:566	the pathogenic bacterium Citrobacter rodentium	521:566	the pathogenic bacterium Citrobacter rodentium	521:566	Administration of the pathogenic bacterium Citrobacter rodentium, further aggravated the inflammation and mucosal damage in the presence of κ-CGN.
34893247	5	29	from	mice	758:761	arg1	transplantation					727:741	fecal transplantation	721:741	fecal transplantation from κ-CGN-fed mice, but not from germ-free κ-CGN-fed mice	721:800	Mucus layer degradation and altered SCFA levels could be reproduced by fecal transplantation from κ-CGN-fed mice, but not from germ-free κ-CGN-fed mice.
34893247	4	30	theme	rodentium	558:566	arg1	Administration					503:516	Administration	503:516	Administration of the pathogenic bacterium Citrobacter rodentium	503:566	Administration of the pathogenic bacterium Citrobacter rodentium, further aggravated the inflammation and mucosal damage in the presence of κ-CGN.
34893247	5	31	from	mice	797:800	arg1	transplantation					727:741	fecal transplantation	721:741	fecal transplantation from κ-CGN-fed mice, but not from germ-free κ-CGN-fed mice	721:800	Mucus layer degradation and altered SCFA levels could be reproduced by fecal transplantation from κ-CGN-fed mice, but not from germ-free κ-CGN-fed mice.
34893247	1	32	theme	ubiquitous	132:141	arg1	food					143:146	a ubiquitous food	130:146	a ubiquitous food additive	130:155	The inflammatory effects of carrageenan (CGN), a ubiquitous food additive, remains controversial.
34893247	1	32	theme	ubiquitous	132:141	arg1	carrageenan					111:121	carrageenan	111:121	carrageenan (CGN)	111:127	The inflammatory effects of carrageenan (CGN), a ubiquitous food additive, remains controversial.
34893247	7	33	theme	pathogens	1075:1083	arg1	expansion					1062:1070	expansion	1062:1070	expansion of pathogens	1062:1083	Our results suggest that κ-CGN may not be directly inflammatory, but it creates an environment that favors inflammation by perturbation of gut microbiota composition and then facilitates expansion of pathogens, and this effect may be partially reversed by the introduction of probiotics.
34893247	3	34	link	bacteria-derived	375:390	arg1	SCFAs					417:421	SCFAs	417:421	SCFAs	417:421	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	3	34	link	bacteria-derived	375:390	arg1	acids					410:414	reduced bacteria-derived short-chain fatty acids	367:414	reduced bacteria-derived short-chain fatty acids (SCFAs)	367:422	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	7	35	theme	microbiota	1018:1027	arg1	composition					1029:1039	gut microbiota composition	1014:1039	gut microbiota composition	1014:1039	Our results suggest that κ-CGN may not be directly inflammatory, but it creates an environment that favors inflammation by perturbation of gut microbiota composition and then facilitates expansion of pathogens, and this effect may be partially reversed by the introduction of probiotics.
34893247	3	36	theme	microbiota	479:488	arg1	composition					490:500	microbiota composition	479:500	microbiota composition	479:500	Here we show that, κ-CGN did not cause significant inflammatory symptoms, but it did cause reduced bacteria-derived short-chain fatty acids (SCFAs) and decreased thickness of the mucus layer by altering microbiota composition.
34893247	2	37	theme	intestinal	200:209	arg1	microbiota					185:194	Gut microbiota	181:194	Gut microbiota	181:194	Gut microbiota and intestinal homeostasis may be a breakthrough in resolving this controversy.
34893247	2	37	theme	intestinal	200:209	arg1	homeostasis					211:221	intestinal homeostasis	200:221	intestinal homeostasis	200:221	Gut microbiota and intestinal homeostasis may be a breakthrough in resolving this controversy.
34893247	2	37	theme	intestinal	200:209	arg1	breakthrough					232:243	a breakthrough	230:243	a breakthrough	230:243	Gut microbiota and intestinal homeostasis may be a breakthrough in resolving this controversy.
34893247	7	38	theme	composition	1029:1039	arg1	perturbation					998:1009	perturbation	998:1009	perturbation of gut microbiota composition	998:1039	Our results suggest that κ-CGN may not be directly inflammatory, but it creates an environment that favors inflammation by perturbation of gut microbiota composition and then facilitates expansion of pathogens, and this effect may be partially reversed by the introduction of probiotics.
34893247	1	39	theme	additive	148:155	arg1	food					143:146	a ubiquitous food	130:146	a ubiquitous food additive	130:155	The inflammatory effects of carrageenan (CGN), a ubiquitous food additive, remains controversial.
34893247	1	39	theme	additive	148:155	arg1	carrageenan					111:121	carrageenan	111:121	carrageenan (CGN)	111:127	The inflammatory effects of carrageenan (CGN), a ubiquitous food additive, remains controversial.
34893247	4	40	theme	κ-CGN	643:647	arg1	presence					631:638	the presence	627:638	the presence of κ-CGN	627:647	Administration of the pathogenic bacterium Citrobacter rodentium, further aggravated the inflammation and mucosal damage in the presence of κ-CGN.
34893247	5	41	theme	germ-free	777:785	arg1	mice					797:800	germ-free κ-CGN-fed mice	777:800	germ-free κ-CGN-fed mice	777:800	Mucus layer degradation and altered SCFA levels could be reproduced by fecal transplantation from κ-CGN-fed mice, but not from germ-free κ-CGN-fed mice.
34893247	4	42	from	inflammation	592:603	arg1	presence					631:638	the presence	627:638	the presence of κ-CGN	627:647	Administration of the pathogenic bacterium Citrobacter rodentium, further aggravated the inflammation and mucosal damage in the presence of κ-CGN.
34920054	0	0	theme	/corn	66:70	arg1	oil					105:107	poly(lactic acid)/corn starch/eucalyptus leaf essential oil	49:107	poly(lactic acid)/corn starch/eucalyptus leaf essential oil	49:107	Preparation, characterization and application of poly(lactic acid)/corn starch/eucalyptus leaf essential oil microencapsulated active bilayer degradable film.
34920054	9	1	theme	EOM	1037:1039	arg1	addition					1025:1032	The addition	1021:1032	The addition of EOM	1021:1039	The addition of EOM also greatly improved the antioxidant and antibacterial properties of the bilayer film.
34920054	2	2	theme	absorbent	307:315	arg1	layer					323:327	an absorbent inner layer	304:327	an absorbent inner layer	304:327	The film had a hydrophobic outer layer and an absorbent inner layer.
34920054	10	3	theme	best	1133:1136	arg1	performance					1138:1148	The best performance	1129:1148	The best performance	1129:1148	The best performance was obtained when the added amount was 15 mL/100 mL.
34920054	8	4	from	cracks	1001:1006	arg1	film					1015:1018	the film	1011:1018	the film	1011:1018	The addition of too much EOM led to cracks in the film.
34920054	13	5	theme	bisporus	1510:1517	arg1	life					1499:1502	the shelf life	1489:1502	the shelf life of A. bisporus	1489:1517	Compared with other cling films, the shelf life of A. bisporus was greatly extended.
34920054	7	6	theme	EOM	873:875	arg1	15 mL/100 mL					857:868	15 mL/100 mL	857:868	15 mL/100 mL of EOM	857:875	The addition of less than 15 mL/100 mL of EOM to the film improved its tensile strength, barrier properties, and elongation at break.
34920054	9	7	theme	film	1123:1126	arg1	properties					1097:1106	the antioxidant and antibacterial properties	1063:1106	the antioxidant and antibacterial properties of the bilayer film	1063:1126	The addition of EOM also greatly improved the antioxidant and antibacterial properties of the bilayer film.
34920054	12	8	dep	bisporus	1362:1369	arg1	A.					1359:1360	A. bisporus	1359:1369	A. bisporus	1359:1369	In preservation experiments, this film inhibited the respiration rate of A. bisporus, slowed down the consumption of organic matter, and maintained its moisture content.
34920054	0	9	theme	leaf	90:93	arg1	oil					105:107	poly(lactic acid)/corn starch/eucalyptus leaf essential oil	49:107	poly(lactic acid)/corn starch/eucalyptus leaf essential oil	49:107	Preparation, characterization and application of poly(lactic acid)/corn starch/eucalyptus leaf essential oil microencapsulated active bilayer degradable film.
34920054	12	10	theme	respiration	1339:1349	arg1	rate					1351:1354	the respiration rate	1335:1354	the respiration rate of A. bisporus	1335:1369	In preservation experiments, this film inhibited the respiration rate of A. bisporus, slowed down the consumption of organic matter, and maintained its moisture content.
34920054	5	11	theme	physical	592:599	arg1	properties					645:654	the physical, mechanical, antioxidant, and antimicrobial properties	588:654	the physical, mechanical, antioxidant, and antimicrobial properties of the films	588:667	The effects of different amounts of EOM on the physical, mechanical, antioxidant, and antimicrobial properties of the films were investigated.
34920054	13	12	theme	other	1470:1474	arg1	films					1482:1486	other cling films	1470:1486	other cling films	1470:1486	Compared with other cling films, the shelf life of A. bisporus was greatly extended.
34920054	1	13	theme	/polylactic	237:247	arg1	PLA					255:257	PLA	255:257	PLA	255:257	This study aimed to develop a composite bilayer film based on corn starch (CS)/polylactic acid (PLA).
34920054	1	13	theme	/polylactic	237:247	arg1	acid					249:252	corn starch (CS)/polylactic acid	221:252	corn starch (CS)/polylactic acid (PLA)	221:258	This study aimed to develop a composite bilayer film based on corn starch (CS)/polylactic acid (PLA).
34920054	0	14	theme	starch/eucalyptus	72:88	arg1	oil					105:107	poly(lactic acid)/corn starch/eucalyptus leaf essential oil	49:107	poly(lactic acid)/corn starch/eucalyptus leaf essential oil	49:107	Preparation, characterization and application of poly(lactic acid)/corn starch/eucalyptus leaf essential oil microencapsulated active bilayer degradable film.
34920054	13	15	theme	cling	1476:1480	arg1	films					1482:1486	other cling films	1470:1486	other cling films	1470:1486	Compared with other cling films, the shelf life of A. bisporus was greatly extended.
34920054	4	16	theme	storage	524:530	arg1	environment					532:542	the storage environment	520:542	the storage environment	520:542	This allowed most of the bioactive substance to be released inside the storage environment.
34920054	0	17	theme	oil	105:107	arg1	characterization					13:28	characterization	13:28	characterization	13:28	Preparation, characterization and application of poly(lactic acid)/corn starch/eucalyptus leaf essential oil microencapsulated active bilayer degradable film.
34920054	0	17	theme	oil	105:107	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation, characterization and application of poly(lactic acid)/corn starch/eucalyptus leaf essential oil microencapsulated active bilayer degradable film.
34920054	0	17	theme	oil	105:107	arg1	application					34:44	application	34:44	application	34:44	Preparation, characterization and application of poly(lactic acid)/corn starch/eucalyptus leaf essential oil microencapsulated active bilayer degradable film.
34920054	5	18	theme	different	560:568	arg1	EOM					581:583	EOM	581:583	EOM	581:583	The effects of different amounts of EOM on the physical, mechanical, antioxidant, and antimicrobial properties of the films were investigated.
34920054	5	18	theme	different	560:568	arg1	amounts					570:576	different amounts	560:576	different amounts of EOM	560:583	The effects of different amounts of EOM on the physical, mechanical, antioxidant, and antimicrobial properties of the films were investigated.
34920054	3	19	theme	essential	418:426	arg1	layer					392:396	the inner layer	382:396	the inner layer	382:396	A natural bioactive substance was incorporated into the inner layer, namely, eucalyptus essential oil microcapsules (EOM).
34920054	3	19	theme	essential	418:426	arg1	EOM					447:449	EOM	447:449	EOM	447:449	A natural bioactive substance was incorporated into the inner layer, namely, eucalyptus essential oil microcapsules (EOM).
34920054	3	19	theme	essential	418:426	arg1	microcapsules					432:444	eucalyptus essential oil microcapsules	407:444	eucalyptus essential oil microcapsules (EOM)	407:450	A natural bioactive substance was incorporated into the inner layer, namely, eucalyptus essential oil microcapsules (EOM).
34920054	12	20	theme	preservation	1289:1300	arg1	experiments					1302:1312	preservation experiments	1289:1312	preservation experiments	1289:1312	In preservation experiments, this film inhibited the respiration rate of A. bisporus, slowed down the consumption of organic matter, and maintained its moisture content.
34920054	11	21	theme	overall	1223:1229	arg1	properties					1231:1240	the best overall properties	1214:1240	the best overall properties	1214:1240	Films with the best overall properties were used for preserving Agaricus bisporus.
34920054	0	22	theme	essential	95:103	arg1	oil					105:107	poly(lactic acid)/corn starch/eucalyptus leaf essential oil	49:107	poly(lactic acid)/corn starch/eucalyptus leaf essential oil	49:107	Preparation, characterization and application of poly(lactic acid)/corn starch/eucalyptus leaf essential oil microencapsulated active bilayer degradable film.
34920054	5	23	theme	amounts	570:576	arg1	effects					549:555	The effects	545:555	The effects of different amounts of EOM on the physical, mechanical, antioxidant, and antimicrobial properties of the films	545:667	The effects of different amounts of EOM on the physical, mechanical, antioxidant, and antimicrobial properties of the films were investigated.
34920054	6	24	theme	electron	721:728	arg1	SEM					742:744	SEM	742:744	SEM	742:744	Based on the results of scanning electron microscopy (SEM), the addition of 10-15 mL/100 mL of EOM could be uniformly distributed in the film.
34920054	6	24	theme	electron	721:728	arg1	microscopy					730:739	scanning electron microscopy	712:739	scanning electron microscopy (SEM)	712:745	Based on the results of scanning electron microscopy (SEM), the addition of 10-15 mL/100 mL of EOM could be uniformly distributed in the film.
34920054	1	25	theme	corn	221:224	arg1	starch					226:231	corn starch	221:231	corn starch (CS)/polylactic acid (PLA)	221:258	This study aimed to develop a composite bilayer film based on corn starch (CS)/polylactic acid (PLA).
34920054	1	25	theme	corn	221:224	arg1	CS					234:235	CS	234:235	CS	234:235	This study aimed to develop a composite bilayer film based on corn starch (CS)/polylactic acid (PLA).
34920054	8	26	theme	much	985:988	arg1	EOM					990:992	too much EOM	981:992	too much EOM	981:992	The addition of too much EOM led to cracks in the film.
34920054	4	27	theme	bioactive	478:486	arg1	substance					488:496	the bioactive substance	474:496	the bioactive substance	474:496	This allowed most of the bioactive substance to be released inside the storage environment.
34920054	3	28	theme	natural	332:338	arg1	substance					350:358	A natural bioactive substance	330:358	A natural bioactive substance	330:358	A natural bioactive substance was incorporated into the inner layer, namely, eucalyptus essential oil microcapsules (EOM).
34920054	13	29	dep	bisporus	1510:1517	arg1	A.					1507:1508	A. bisporus	1507:1517	A. bisporus	1507:1517	Compared with other cling films, the shelf life of A. bisporus was greatly extended.
34920054	6	30	theme	scanning	712:719	arg1	SEM					742:744	SEM	742:744	SEM	742:744	Based on the results of scanning electron microscopy (SEM), the addition of 10-15 mL/100 mL of EOM could be uniformly distributed in the film.
34920054	6	30	theme	scanning	712:719	arg1	microscopy					730:739	scanning electron microscopy	712:739	scanning electron microscopy (SEM)	712:745	Based on the results of scanning electron microscopy (SEM), the addition of 10-15 mL/100 mL of EOM could be uniformly distributed in the film.
34920054	13	31	theme	shelf	1493:1497	arg1	life					1499:1502	the shelf life	1489:1502	the shelf life of A. bisporus	1489:1517	Compared with other cling films, the shelf life of A. bisporus was greatly extended.
34920054	3	32	theme	bioactive	340:348	arg1	substance					350:358	A natural bioactive substance	330:358	A natural bioactive substance	330:358	A natural bioactive substance was incorporated into the inner layer, namely, eucalyptus essential oil microcapsules (EOM).
34920054	5	33	theme	EOM	581:583	arg1	EOM					581:583	EOM	581:583	EOM	581:583	The effects of different amounts of EOM on the physical, mechanical, antioxidant, and antimicrobial properties of the films were investigated.
34920054	5	33	theme	EOM	581:583	arg1	amounts					570:576	different amounts	560:576	different amounts of EOM	560:583	The effects of different amounts of EOM on the physical, mechanical, antioxidant, and antimicrobial properties of the films were investigated.
34920054	9	34	theme	antibacterial	1083:1095	arg1	properties					1097:1106	the antioxidant and antibacterial properties	1063:1106	the antioxidant and antibacterial properties of the bilayer film	1063:1126	The addition of EOM also greatly improved the antioxidant and antibacterial properties of the bilayer film.
34920054	11	35	with	Films	1203:1207	arg1	properties					1231:1240	the best overall properties	1214:1240	the best overall properties	1214:1240	Films with the best overall properties were used for preserving Agaricus bisporus.
34920054	3	36	theme	inner	386:390	arg1	layer					392:396	the inner layer	382:396	the inner layer	382:396	A natural bioactive substance was incorporated into the inner layer, namely, eucalyptus essential oil microcapsules (EOM).
34920054	3	36	theme	inner	386:390	arg1	microcapsules					432:444	eucalyptus essential oil microcapsules	407:444	eucalyptus essential oil microcapsules (EOM)	407:450	A natural bioactive substance was incorporated into the inner layer, namely, eucalyptus essential oil microcapsules (EOM).
34920054	0	37	theme	active	127:132	arg1	film					153:156	active bilayer degradable film	127:156	active bilayer degradable film	127:156	Preparation, characterization and application of poly(lactic acid)/corn starch/eucalyptus leaf essential oil microencapsulated active bilayer degradable film.
34920054	6	38	theme	microscopy	730:739	arg1	results					701:707	the results	697:707	the results of scanning electron microscopy (SEM)	697:745	Based on the results of scanning electron microscopy (SEM), the addition of 10-15 mL/100 mL of EOM could be uniformly distributed in the film.
34920054	9	39	theme	antioxidant	1067:1077	arg1	properties					1097:1106	the antioxidant and antibacterial properties	1063:1106	the antioxidant and antibacterial properties of the bilayer film	1063:1126	The addition of EOM also greatly improved the antioxidant and antibacterial properties of the bilayer film.
34920054	1	40	theme	composite	189:197	arg1	film					207:210	a composite bilayer film	187:210	a composite bilayer film based on corn starch (CS)/polylactic acid (PLA)	187:258	This study aimed to develop a composite bilayer film based on corn starch (CS)/polylactic acid (PLA).
34920054	5	41	theme	antimicrobial	631:643	arg1	properties					645:654	the physical, mechanical, antioxidant, and antimicrobial properties	588:654	the physical, mechanical, antioxidant, and antimicrobial properties of the films	588:667	The effects of different amounts of EOM on the physical, mechanical, antioxidant, and antimicrobial properties of the films were investigated.
34920054	11	42	used	used	1247:1250	arg2	Films					1203:1207	Films	1203:1207	Films with the best overall properties	1203:1240	Films with the best overall properties were used for preserving Agaricus bisporus.
34920054	1	43	theme	bilayer	199:205	arg1	film					207:210	a composite bilayer film	187:210	a composite bilayer film based on corn starch (CS)/polylactic acid (PLA)	187:258	This study aimed to develop a composite bilayer film based on corn starch (CS)/polylactic acid (PLA).
34920054	12	44	theme	organic	1403:1409	arg1	matter					1411:1416	organic matter	1403:1416	organic matter	1403:1416	In preservation experiments, this film inhibited the respiration rate of A. bisporus, slowed down the consumption of organic matter, and maintained its moisture content.
34920054	0	45	theme	degradable	142:151	arg1	film					153:156	active bilayer degradable film	127:156	active bilayer degradable film	127:156	Preparation, characterization and application of poly(lactic acid)/corn starch/eucalyptus leaf essential oil microencapsulated active bilayer degradable film.
34920054	6	46	theme	EOM	783:785	arg1	10-15 mL/100 mL					764:778	10-15 mL/100 mL	764:778	10-15 mL/100 mL of EOM	764:785	Based on the results of scanning electron microscopy (SEM), the addition of 10-15 mL/100 mL of EOM could be uniformly distributed in the film.
34920054	10	47	theme	added	1172:1176	arg1	amount					1178:1183	the added amount	1168:1183	the added amount	1168:1183	The best performance was obtained when the added amount was 15 mL/100 mL.
34920054	10	47	theme	added	1172:1176	arg1	15 mL/100 mL					1189:1200	15 mL/100 mL	1189:1200	15 mL/100 mL	1189:1200	The best performance was obtained when the added amount was 15 mL/100 mL.
34920054	0	48	theme	bilayer	134:140	arg1	film					153:156	active bilayer degradable film	127:156	active bilayer degradable film	127:156	Preparation, characterization and application of poly(lactic acid)/corn starch/eucalyptus leaf essential oil microencapsulated active bilayer degradable film.
34920054	9	49	theme	bilayer	1115:1121	arg1	film					1123:1126	the bilayer film	1111:1126	the bilayer film	1111:1126	The addition of EOM also greatly improved the antioxidant and antibacterial properties of the bilayer film.
34920054	12	50	theme	moisture	1438:1445	arg1	content					1447:1453	its moisture content	1434:1453	its moisture content	1434:1453	In preservation experiments, this film inhibited the respiration rate of A. bisporus, slowed down the consumption of organic matter, and maintained its moisture content.
34920054	11	51	theme	best	1218:1221	arg1	properties					1231:1240	the best overall properties	1214:1240	the best overall properties	1214:1240	Films with the best overall properties were used for preserving Agaricus bisporus.
34920054	5	52	theme	mechanical	602:611	arg1	properties					645:654	the physical, mechanical, antioxidant, and antimicrobial properties	588:654	the physical, mechanical, antioxidant, and antimicrobial properties of the films	588:667	The effects of different amounts of EOM on the physical, mechanical, antioxidant, and antimicrobial properties of the films were investigated.
34920054	6	53	theme	10-15 mL/100 mL	764:778	arg1	addition					752:759	the addition	748:759	the addition of 10-15 mL/100 mL of EOM	748:785	Based on the results of scanning electron microscopy (SEM), the addition of 10-15 mL/100 mL of EOM could be uniformly distributed in the film.
34920054	7	54	theme	barrier	920:926	arg1	properties					928:937	barrier properties	920:937	barrier properties	920:937	The addition of less than 15 mL/100 mL of EOM to the film improved its tensile strength, barrier properties, and elongation at break.
34920054	0	55	theme	poly	49:52	arg1	oil					105:107	poly(lactic acid)/corn starch/eucalyptus leaf essential oil	49:107	poly(lactic acid)/corn starch/eucalyptus leaf essential oil	49:107	Preparation, characterization and application of poly(lactic acid)/corn starch/eucalyptus leaf essential oil microencapsulated active bilayer degradable film.
34920054	2	56	contain	had	270:272	arg2	layer					323:327	an absorbent inner layer	304:327	an absorbent inner layer	304:327	The film had a hydrophobic outer layer and an absorbent inner layer.
34920054	2	56	contain	had	270:272	arg1	film					265:268	The film	261:268	The film	261:268	The film had a hydrophobic outer layer and an absorbent inner layer.
34920054	2	56	contain	had	270:272	arg2	layer					294:298	a hydrophobic outer layer	274:298	a hydrophobic outer layer	274:298	The film had a hydrophobic outer layer and an absorbent inner layer.
34920054	8	57	theme	EOM	990:992	arg1	addition					969:976	The addition	965:976	The addition of too much EOM	965:992	The addition of too much EOM led to cracks in the film.
34920054	7	58	theme	tensile	902:908	arg1	strength					910:917	its tensile strength	898:917	its tensile strength	898:917	The addition of less than 15 mL/100 mL of EOM to the film improved its tensile strength, barrier properties, and elongation at break.
34920054	5	59	theme	antioxidant	614:624	arg1	properties					645:654	the physical, mechanical, antioxidant, and antimicrobial properties	588:654	the physical, mechanical, antioxidant, and antimicrobial properties of the films	588:667	The effects of different amounts of EOM on the physical, mechanical, antioxidant, and antimicrobial properties of the films were investigated.
34920054	7	60	theme	less	847:850	arg1	addition					835:842	The addition	831:842	The addition of less than 15 mL/100 mL of EOM to the film	831:887	The addition of less than 15 mL/100 mL of EOM to the film improved its tensile strength, barrier properties, and elongation at break.
34920054	3	61	theme	oil	428:430	arg1	layer					392:396	the inner layer	382:396	the inner layer	382:396	A natural bioactive substance was incorporated into the inner layer, namely, eucalyptus essential oil microcapsules (EOM).
34920054	3	61	theme	oil	428:430	arg1	EOM					447:449	EOM	447:449	EOM	447:449	A natural bioactive substance was incorporated into the inner layer, namely, eucalyptus essential oil microcapsules (EOM).
34920054	3	61	theme	oil	428:430	arg1	microcapsules					432:444	eucalyptus essential oil microcapsules	407:444	eucalyptus essential oil microcapsules (EOM)	407:450	A natural bioactive substance was incorporated into the inner layer, namely, eucalyptus essential oil microcapsules (EOM).
34920054	2	62	theme	hydrophobic	276:286	arg1	layer					294:298	a hydrophobic outer layer	274:298	a hydrophobic outer layer	274:298	The film had a hydrophobic outer layer and an absorbent inner layer.
34920054	2	63	theme	outer	288:292	arg1	layer					294:298	a hydrophobic outer layer	274:298	a hydrophobic outer layer	274:298	The film had a hydrophobic outer layer and an absorbent inner layer.
34920054	12	64	theme	bisporus	1362:1369	arg1	rate					1351:1354	the respiration rate	1335:1354	the respiration rate of A. bisporus	1335:1369	In preservation experiments, this film inhibited the respiration rate of A. bisporus, slowed down the consumption of organic matter, and maintained its moisture content.
34920054	12	65	theme	matter	1411:1416	arg1	consumption					1388:1398	the consumption	1384:1398	the consumption of organic matter	1384:1416	In preservation experiments, this film inhibited the respiration rate of A. bisporus, slowed down the consumption of organic matter, and maintained its moisture content.
34920054	3	66	theme	eucalyptus	407:416	arg1	layer					392:396	the inner layer	382:396	the inner layer	382:396	A natural bioactive substance was incorporated into the inner layer, namely, eucalyptus essential oil microcapsules (EOM).
34920054	3	66	theme	eucalyptus	407:416	arg1	EOM					447:449	EOM	447:449	EOM	447:449	A natural bioactive substance was incorporated into the inner layer, namely, eucalyptus essential oil microcapsules (EOM).
34920054	3	66	theme	eucalyptus	407:416	arg1	microcapsules					432:444	eucalyptus essential oil microcapsules	407:444	eucalyptus essential oil microcapsules (EOM)	407:450	A natural bioactive substance was incorporated into the inner layer, namely, eucalyptus essential oil microcapsules (EOM).
34920054	5	67	from	effects	549:555	arg1	properties					645:654	the physical, mechanical, antioxidant, and antimicrobial properties	588:654	the physical, mechanical, antioxidant, and antimicrobial properties of the films	588:667	The effects of different amounts of EOM on the physical, mechanical, antioxidant, and antimicrobial properties of the films were investigated.
34920054	1	68	theme	starch	226:231	arg1	PLA					255:257	PLA	255:257	PLA	255:257	This study aimed to develop a composite bilayer film based on corn starch (CS)/polylactic acid (PLA).
34920054	1	68	theme	starch	226:231	arg1	acid					249:252	corn starch (CS)/polylactic acid	221:252	corn starch (CS)/polylactic acid (PLA)	221:258	This study aimed to develop a composite bilayer film based on corn starch (CS)/polylactic acid (PLA).
34920054	0	69	theme	lactic	54:59	arg1	poly					49:52	poly	49:52	poly(lactic acid)/corn starch/eucalyptus leaf essential oil	49:107	Preparation, characterization and application of poly(lactic acid)/corn starch/eucalyptus leaf essential oil microencapsulated active bilayer degradable film.
34920054	0	69	theme	lactic	54:59	arg1	acid					61:64	lactic acid	54:64	lactic acid	54:64	Preparation, characterization and application of poly(lactic acid)/corn starch/eucalyptus leaf essential oil microencapsulated active bilayer degradable film.
34920054	2	70	theme	inner	317:321	arg1	layer					323:327	an absorbent inner layer	304:327	an absorbent inner layer	304:327	The film had a hydrophobic outer layer and an absorbent inner layer.
34920054	5	71	theme	films	663:667	arg1	properties					645:654	the physical, mechanical, antioxidant, and antimicrobial properties	588:654	the physical, mechanical, antioxidant, and antimicrobial properties of the films	588:667	The effects of different amounts of EOM on the physical, mechanical, antioxidant, and antimicrobial properties of the films were investigated.
33712151	5	0	theme	HA	762:763	arg1	gels					765:768	HA gels	762:768	HA gels	762:768	Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications.
33712151	10	1	theme	HA	1497:1498	arg1	derivatives					1500:1510	the HA derivatives	1493:1510	the HA derivatives	1493:1510	Antimicrobial activity of the HA derivatives were tested against Staphylococcus aureus and the results reveal antibacterial effect.
33712151	10	2	theme	derivatives	1500:1510	arg1	activity					1481:1488	Antimicrobial activity	1467:1488	Antimicrobial activity of the HA derivatives	1467:1510	Antimicrobial activity of the HA derivatives were tested against Staphylococcus aureus and the results reveal antibacterial effect.
33712151	6	3	theme	surface	977:983	arg1	area					985:988	their high surface area	966:988	their high surface area	966:988	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	10	4	theme	Antimicrobial	1467:1479	arg1	activity					1481:1488	Antimicrobial activity	1467:1488	Antimicrobial activity of the HA derivatives	1467:1510	Antimicrobial activity of the HA derivatives were tested against Staphylococcus aureus and the results reveal antibacterial effect.
33712151	9	5	theme	new	1344:1346	arg1	derivatives					1351:1361	These new HA derivatives	1338:1361	These new HA derivatives	1338:1361	These new HA derivatives exhibit excellent mechanical properties and are capable of withstanding physiological stresses in vivo.
33712151	8	6	theme	BIED	1256:1259	arg1	effects					1237:1243	The effects	1233:1243	The effects of CNF and BIED on the structural, mechanical, thermal, and swelling behaviour	1233:1322	The effects of CNF and BIED on the structural, mechanical, thermal, and swelling behaviour are examined.
33712151	11	7	theme	carbohydrate	1605:1616	arg1	materials					1624:1632	These carbohydrate based materials	1599:1632	These carbohydrate based materials	1599:1632	These carbohydrate based materials have potential application on surfaces within clinical settings where staphylococcal contamination is currently an issue.
33712151	6	8	theme	reinforcing	853:863	arg1	nanofibers					891:900	carbon nanofibers	884:900	carbon nanofibers (CNF)	884:906	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	6	8	theme	reinforcing	853:863	arg1	materials					865:873	carbon-based reinforcing materials	840:873	carbon-based reinforcing materials	840:873	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	9	9	theme	HA	1348:1349	arg1	derivatives					1351:1361	These new HA derivatives	1338:1361	These new HA derivatives	1338:1361	These new HA derivatives exhibit excellent mechanical properties and are capable of withstanding physiological stresses in vivo.
33712151	11	10	theme	based	1618:1622	arg1	materials					1624:1632	These carbohydrate based materials	1599:1632	These carbohydrate based materials	1599:1632	These carbohydrate based materials have potential application on surfaces within clinical settings where staphylococcal contamination is currently an issue.
33712151	7	11	dep	disulphide	1152:1161	arg1	BIED					1164:1167	BIED	1164:1167	BIED	1164:1167	We utilise bis-(β-isocyanatoethyl) disulphide (BIED) as the crosslinker with the gel reinforced using 0.25 wt% CNF.
33712151	8	12	theme	mechanical	1280:1289	arg1	behaviour					1314:1322	the structural, mechanical, thermal, and swelling behaviour	1264:1322	the structural, mechanical, thermal, and swelling behaviour	1264:1322	The effects of CNF and BIED on the structural, mechanical, thermal, and swelling behaviour are examined.
33712151	8	13	theme	swelling	1305:1312	arg1	behaviour					1314:1322	the structural, mechanical, thermal, and swelling behaviour	1264:1322	the structural, mechanical, thermal, and swelling behaviour	1264:1322	The effects of CNF and BIED on the structural, mechanical, thermal, and swelling behaviour are examined.
33712151	2	14	theme	contact	291:297	arg1	lenses					299:304	contact lenses	291:304	contact lenses	291:304	These contaminations are frequently caused by Staphylococcus aureus and are a pressing issue for implantable devices, catheters, contact lenses, prostheses, and wound dressings.
33712151	5	15	from	strategies	703:712	arg1	gels					765:768	HA gels	762:768	HA gels	762:768	Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications.
33712151	4	16	theme	hyaluronic	480:489	arg1	polymer					535:541	a naturally derived carbohydrate polymer	502:541	a naturally derived carbohydrate polymer	502:541	In this context, hyaluronic acid (HA), a naturally derived carbohydrate polymer, known to be biocompatible, degradable, and immunomodulatory, has shown some antimicrobial activity effects.
33712151	4	16	theme	hyaluronic	480:489	arg1	HA					497:498	HA	497:498	HA	497:498	In this context, hyaluronic acid (HA), a naturally derived carbohydrate polymer, known to be biocompatible, degradable, and immunomodulatory, has shown some antimicrobial activity effects.
33712151	4	16	theme	hyaluronic	480:489	arg1	acid					491:494	hyaluronic acid	480:494	hyaluronic acid (HA)	480:499	In this context, hyaluronic acid (HA), a naturally derived carbohydrate polymer, known to be biocompatible, degradable, and immunomodulatory, has shown some antimicrobial activity effects.
33712151	8	17	from	effects	1237:1243	arg1	behaviour					1314:1322	the structural, mechanical, thermal, and swelling behaviour	1264:1322	the structural, mechanical, thermal, and swelling behaviour	1264:1322	The effects of CNF and BIED on the structural, mechanical, thermal, and swelling behaviour are examined.
33712151	1	18	theme	Biofilm-related	67:81	arg1	problems					138:145	major problems	132:145	major problems in the clinic	132:159	Biofilm-related infections and contamination of biomaterials are major problems in the clinic.
33712151	1	18	theme	Biofilm-related	67:81	arg1	contamination					98:110	contamination	98:110	contamination of biomaterials	98:126	Biofilm-related infections and contamination of biomaterials are major problems in the clinic.
33712151	1	18	theme	Biofilm-related	67:81	arg1	infections					83:92	Biofilm-related infections	67:92	Biofilm-related infections	67:92	Biofilm-related infections and contamination of biomaterials are major problems in the clinic.
33712151	3	19	theme	biomaterials	449:460	arg1	success					426:432	the success	422:432	the success of implantable biomaterials	422:460	Strategies to decrease contamination and biofilm related infections are vital for the success of implantable biomaterials.
33712151	5	20	theme	reinforcing	740:750	arg1	fibres					752:757	reinforcing fibres	740:757	reinforcing fibres	740:757	Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications.
33712151	6	21	theme	carbon	884:889	arg1	nanofibers					891:900	carbon nanofibers	884:900	carbon nanofibers (CNF)	884:906	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	6	21	theme	carbon	884:889	arg1	CNF					903:905	CNF	903:905	CNF	903:905	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	1	22	from	problems	138:145	arg1	clinic					154:159	the clinic	150:159	the clinic	150:159	Biofilm-related infections and contamination of biomaterials are major problems in the clinic.
33712151	9	23	theme	mechanical	1381:1390	arg1	properties					1392:1401	excellent mechanical properties	1371:1401	excellent mechanical properties	1371:1401	These new HA derivatives exhibit excellent mechanical properties and are capable of withstanding physiological stresses in vivo.
33712151	5	24	theme	tailored	793:800	arg1	gels					802:805	tailored gels	793:805	tailored gels for varying applications	793:830	Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications.
33712151	4	25	link	derived	514:520	arg1	polymer					535:541	a naturally derived carbohydrate polymer	502:541	a naturally derived carbohydrate polymer	502:541	In this context, hyaluronic acid (HA), a naturally derived carbohydrate polymer, known to be biocompatible, degradable, and immunomodulatory, has shown some antimicrobial activity effects.
33712151	4	25	link	derived	514:520	arg1	acid					491:494	hyaluronic acid	480:494	hyaluronic acid (HA)	480:499	In this context, hyaluronic acid (HA), a naturally derived carbohydrate polymer, known to be biocompatible, degradable, and immunomodulatory, has shown some antimicrobial activity effects.
33712151	6	26	theme	high	972:975	arg1	area					985:988	their high surface area	966:988	their high surface area	966:988	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	3	27	theme	implantable	437:447	arg1	biomaterials					449:460	implantable biomaterials	437:460	implantable biomaterials	437:460	Strategies to decrease contamination and biofilm related infections are vital for the success of implantable biomaterials.
33712151	5	28	theme	crosslinking	690:701	arg1	strategies					703:712	crosslinking strategies	690:712	crosslinking strategies	690:712	Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications.
33712151	4	29	theme	antimicrobial	620:632	arg1	effects					643:649	some antimicrobial activity effects	615:649	some antimicrobial activity effects	615:649	In this context, hyaluronic acid (HA), a naturally derived carbohydrate polymer, known to be biocompatible, degradable, and immunomodulatory, has shown some antimicrobial activity effects.
33712151	3	30	theme	related	389:395	arg1	infections					397:406	related infections	389:406	related infections	389:406	Strategies to decrease contamination and biofilm related infections are vital for the success of implantable biomaterials.
33712151	8	31	theme	thermal	1292:1298	arg1	behaviour					1314:1322	the structural, mechanical, thermal, and swelling behaviour	1264:1322	the structural, mechanical, thermal, and swelling behaviour	1264:1322	The effects of CNF and BIED on the structural, mechanical, thermal, and swelling behaviour are examined.
33712151	1	32	theme	biomaterials	115:126	arg1	problems					138:145	major problems	132:145	major problems in the clinic	132:159	Biofilm-related infections and contamination of biomaterials are major problems in the clinic.
33712151	1	32	theme	biomaterials	115:126	arg1	contamination					98:110	contamination	98:110	contamination of biomaterials	98:126	Biofilm-related infections and contamination of biomaterials are major problems in the clinic.
33712151	1	32	theme	biomaterials	115:126	arg1	infections					83:92	Biofilm-related infections	67:92	Biofilm-related infections	67:92	Biofilm-related infections and contamination of biomaterials are major problems in the clinic.
33712151	11	33	contain	have	1634:1637	arg1	materials					1624:1632	These carbohydrate based materials	1599:1632	These carbohydrate based materials	1599:1632	These carbohydrate based materials have potential application on surfaces within clinical settings where staphylococcal contamination is currently an issue.
33712151	11	33	contain	have	1634:1637	arg2	application					1649:1659	potential application	1639:1659	potential application	1639:1659	These carbohydrate based materials have potential application on surfaces within clinical settings where staphylococcal contamination is currently an issue.
33712151	0	34	theme	hyaluronic	34:43	arg1	films					60:64	hyaluronic acid composite films	34:64	hyaluronic acid composite films	34:64	On the bacteriostatic activity of hyaluronic acid composite films.
33712151	6	35	theme	related	955:961	arg1	activity					946:953	some intrinsic antimicrobial activity	917:953	some intrinsic antimicrobial activity related to their high surface area	917:988	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	10	36	theme	antibacterial	1577:1589	arg1	effect					1591:1596	antibacterial effect	1577:1596	antibacterial effect	1577:1596	Antimicrobial activity of the HA derivatives were tested against Staphylococcus aureus and the results reveal antibacterial effect.
33712151	9	37	theme	excellent	1371:1379	arg1	properties					1392:1401	excellent mechanical properties	1371:1401	excellent mechanical properties	1371:1401	These new HA derivatives exhibit excellent mechanical properties and are capable of withstanding physiological stresses in vivo.
33712151	4	38	theme	carbohydrate	522:533	arg1	polymer					535:541	a naturally derived carbohydrate polymer	502:541	a naturally derived carbohydrate polymer	502:541	In this context, hyaluronic acid (HA), a naturally derived carbohydrate polymer, known to be biocompatible, degradable, and immunomodulatory, has shown some antimicrobial activity effects.
33712151	4	38	theme	carbohydrate	522:533	arg1	acid					491:494	hyaluronic acid	480:494	hyaluronic acid (HA)	480:499	In this context, hyaluronic acid (HA), a naturally derived carbohydrate polymer, known to be biocompatible, degradable, and immunomodulatory, has shown some antimicrobial activity effects.
33712151	3	39	dep	Strategies	340:349	arg1	decrease					354:361	decrease	354:361	to decrease contamination and biofilm related infections	351:406	Strategies to decrease contamination and biofilm related infections are vital for the success of implantable biomaterials.
33712151	2	40	theme	pressing	240:247	arg1	issue					249:253	a pressing issue	238:253	a pressing issue for implantable devices, catheters, contact lenses, prostheses, and wound dressings	238:337	These contaminations are frequently caused by Staphylococcus aureus and are a pressing issue for implantable devices, catheters, contact lenses, prostheses, and wound dressings.
33712151	4	41	theme	activity	634:641	arg1	effects					643:649	some antimicrobial activity effects	615:649	some antimicrobial activity effects	615:649	In this context, hyaluronic acid (HA), a naturally derived carbohydrate polymer, known to be biocompatible, degradable, and immunomodulatory, has shown some antimicrobial activity effects.
33712151	0	42	theme	composite	50:58	arg1	films					60:64	hyaluronic acid composite films	34:64	hyaluronic acid composite films	34:64	On the bacteriostatic activity of hyaluronic acid composite films.
33712151	4	43	theme	derived	514:520	arg1	polymer					535:541	a naturally derived carbohydrate polymer	502:541	a naturally derived carbohydrate polymer	502:541	In this context, hyaluronic acid (HA), a naturally derived carbohydrate polymer, known to be biocompatible, degradable, and immunomodulatory, has shown some antimicrobial activity effects.
33712151	4	43	theme	derived	514:520	arg1	acid					491:494	hyaluronic acid	480:494	hyaluronic acid (HA)	480:499	In this context, hyaluronic acid (HA), a naturally derived carbohydrate polymer, known to be biocompatible, degradable, and immunomodulatory, has shown some antimicrobial activity effects.
33712151	5	44	theme	poor	663:666	arg1	stability					679:687	its poor structural stability	659:687	its poor structural stability	659:687	Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications.
33712151	5	45	from	incorporation	723:735	arg1	gels					765:768	HA gels	762:768	HA gels	762:768	Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications.
33712151	6	46	dep	strategy	1014:1021	arg1	regulate					1064:1071	regulate	1064:1071	regulate the rate of degradation of HA	1064:1101	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	6	46	dep	strategy	1014:1021	arg1	enhance					1026:1032	enhance	1026:1032	enhance the mechanical properties	1026:1058	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	9	47	theme	physiological	1435:1447	arg1	stresses					1449:1456	physiological stresses	1435:1456	physiological stresses	1435:1456	These new HA derivatives exhibit excellent mechanical properties and are capable of withstanding physiological stresses in vivo.
33712151	0	48	theme	acid	45:48	arg1	films					60:64	hyaluronic acid composite films	34:64	hyaluronic acid composite films	34:64	On the bacteriostatic activity of hyaluronic acid composite films.
33712151	6	49	theme	intrinsic	922:930	arg1	activity					946:953	some intrinsic antimicrobial activity	917:953	some intrinsic antimicrobial activity related to their high surface area	917:988	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	5	50	theme	structural	668:677	arg1	stability					679:687	its poor structural stability	659:687	its poor structural stability	659:687	Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications.
33712151	6	51	theme	carbon-based	840:851	arg1	nanofibers					891:900	carbon nanofibers	884:900	carbon nanofibers (CNF)	884:906	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	6	51	theme	carbon-based	840:851	arg1	materials					865:873	carbon-based reinforcing materials	840:873	carbon-based reinforcing materials	840:873	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	1	52	theme	major	132:136	arg1	problems					138:145	major problems	132:145	major problems in the clinic	132:159	Biofilm-related infections and contamination of biomaterials are major problems in the clinic.
33712151	1	52	theme	major	132:136	arg1	contamination					98:110	contamination	98:110	contamination of biomaterials	98:126	Biofilm-related infections and contamination of biomaterials are major problems in the clinic.
33712151	1	52	theme	major	132:136	arg1	infections					83:92	Biofilm-related infections	67:92	Biofilm-related infections	67:92	Biofilm-related infections and contamination of biomaterials are major problems in the clinic.
33712151	7	53	theme	wt	1224:1225	arg1	CNF					1228:1230	0.25 wt% CNF	1219:1230	0.25 wt% CNF	1219:1230	We utilise bis-(β-isocyanatoethyl) disulphide (BIED) as the crosslinker with the gel reinforced using 0.25 wt% CNF.
33712151	3	54	dep	contamination	363:375	arg1	infections					397:406	related infections	389:406	related infections	389:406	Strategies to decrease contamination and biofilm related infections are vital for the success of implantable biomaterials.
33712151	7	55	with	crosslinker	1177:1187	arg1	gel					1198:1200	the gel	1194:1200	the gel reinforced using 0.25 wt% CNF	1194:1230	We utilise bis-(β-isocyanatoethyl) disulphide (BIED) as the crosslinker with the gel reinforced using 0.25 wt% CNF.
33712151	7	56	theme	%	1226:1226	arg1	CNF					1228:1230	0.25 wt% CNF	1219:1230	0.25 wt% CNF	1219:1230	We utilise bis-(β-isocyanatoethyl) disulphide (BIED) as the crosslinker with the gel reinforced using 0.25 wt% CNF.
33712151	6	57	theme	HA	1100:1101	arg1	degradation					1085:1095	degradation	1085:1095	degradation of HA	1085:1101	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	5	58	from	stability	679:687	arg1	gels					765:768	HA gels	762:768	HA gels	762:768	Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications.
33712151	11	59	theme	staphylococcal	1704:1717	arg1	contamination					1719:1731	staphylococcal contamination	1704:1731	staphylococcal contamination	1704:1731	These carbohydrate based materials have potential application on surfaces within clinical settings where staphylococcal contamination is currently an issue.
33712151	11	59	theme	staphylococcal	1704:1717	arg1	issue					1749:1753	an issue	1746:1753	an issue	1746:1753	These carbohydrate based materials have potential application on surfaces within clinical settings where staphylococcal contamination is currently an issue.
33712151	5	60	theme	varying	811:817	arg1	applications					819:830	varying applications	811:830	varying applications	811:830	Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications.
33712151	2	61	theme	wound	323:327	arg1	dressings					329:337	wound dressings	323:337	wound dressings	323:337	These contaminations are frequently caused by Staphylococcus aureus and are a pressing issue for implantable devices, catheters, contact lenses, prostheses, and wound dressings.
33712151	8	62	theme	structural	1268:1277	arg1	behaviour					1314:1322	the structural, mechanical, thermal, and swelling behaviour	1264:1322	the structural, mechanical, thermal, and swelling behaviour	1264:1322	The effects of CNF and BIED on the structural, mechanical, thermal, and swelling behaviour are examined.
33712151	6	63	theme	crosslinking	1001:1012	arg1	strategy					1014:1021	a crosslinking strategy	999:1021	a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA	999:1101	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	5	64	theme	fibres	752:757	arg1	stability					679:687	its poor structural stability	659:687	its poor structural stability	659:687	Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications.
33712151	5	64	theme	fibres	752:757	arg1	strategies					703:712	crosslinking strategies	690:712	crosslinking strategies	690:712	Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications.
33712151	5	64	theme	fibres	752:757	arg1	incorporation					723:735	the incorporation	719:735	the incorporation of reinforcing fibres in HA gels	719:768	Due to its poor structural stability, crosslinking strategies, and the incorporation of reinforcing fibres in HA gels is required to produce tailored gels for varying applications.
33712151	2	65	theme	implantable	259:269	arg1	devices					271:277	implantable devices	259:277	implantable devices	259:277	These contaminations are frequently caused by Staphylococcus aureus and are a pressing issue for implantable devices, catheters, contact lenses, prostheses, and wound dressings.
33712151	6	66	theme	mechanical	1038:1047	arg1	properties					1049:1058	the mechanical properties	1034:1058	the mechanical properties	1034:1058	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	11	67	theme	potential	1639:1647	arg1	application					1649:1659	potential application	1639:1659	potential application	1639:1659	These carbohydrate based materials have potential application on surfaces within clinical settings where staphylococcal contamination is currently an issue.
33712151	8	68	theme	CNF	1248:1250	arg1	effects					1237:1243	The effects	1233:1243	The effects of CNF and BIED on the structural, mechanical, thermal, and swelling behaviour	1233:1322	The effects of CNF and BIED on the structural, mechanical, thermal, and swelling behaviour are examined.
33712151	0	69	theme	films	60:64	arg1	activity					22:29	the bacteriostatic activity	3:29	the bacteriostatic activity of hyaluronic acid composite films	3:64	On the bacteriostatic activity of hyaluronic acid composite films.
33712151	0	70	theme	bacteriostatic	7:20	arg1	activity					22:29	the bacteriostatic activity	3:29	the bacteriostatic activity of hyaluronic acid composite films	3:64	On the bacteriostatic activity of hyaluronic acid composite films.
33712151	6	71	theme	degradation	1085:1095	arg1	rate					1077:1080	the rate	1073:1080	the rate of degradation of HA	1073:1101	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33712151	11	72	theme	clinical	1680:1687	arg1	settings					1689:1696	clinical settings	1680:1696	clinical settings where staphylococcal contamination is currently an issue	1680:1753	These carbohydrate based materials have potential application on surfaces within clinical settings where staphylococcal contamination is currently an issue.
33712151	6	73	theme	antimicrobial	932:944	arg1	activity					946:953	some intrinsic antimicrobial activity	917:953	some intrinsic antimicrobial activity related to their high surface area	917:988	Whilst carbon-based reinforcing materials, such as carbon nanofibers (CNF), present some intrinsic antimicrobial activity related to their high surface area, herein, a crosslinking strategy to enhance the mechanical properties and regulate the rate of degradation of HA is presented.
33455432	9	0	from	difference	1383:1392	arg1	bleed					1440:1444	bleed	1440:1444	bleed	1440:1444	When death was removed from the composite end point, there was no significant difference between the cohorts in recurrent VTE or major bleed (HR = 1.18; P = 0.38).
33455432	9	0	from	difference	1383:1392	arg1	VTE					1427:1429	recurrent VTE	1417:1429	recurrent VTE	1417:1429	When death was removed from the composite end point, there was no significant difference between the cohorts in recurrent VTE or major bleed (HR = 1.18; P = 0.38).
33455432	6	1	dep	METHODS	797:803	arg1	examined					852:859	examined	852:859	examined patients treated with enoxaparin for cancer-associated VTE using data from electronic health records	852:960	METHODS This single-center, retrospective cohort study examined patients treated with enoxaparin for cancer-associated VTE using data from electronic health records.
33455432	12	2	with	Patients	1698:1705	arg1	cancer					1712:1717	cancer	1712:1717	cancer	1712:1717	CONCLUSION AND RELEVANCE Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed.
33455432	6	3	from	records	954:960	arg1	data					926:929	data	926:929	data from electronic health records	926:960	METHODS This single-center, retrospective cohort study examined patients treated with enoxaparin for cancer-associated VTE using data from electronic health records.
33455432	5	4	theme	enoxaparin	690:699	arg1	adjustments					721:731	enoxaparin anti-Xa-guided dose adjustments	690:731	enoxaparin anti-Xa-guided dose adjustments	690:731	OBJECTIVE This study aims to evaluate efficacy (recurrent VTE) and safety (major bleed) between enoxaparin anti-Xa-guided dose adjustments and weight-based dosing in patients with cancer-associated VTE.
33455432	1	5	theme	preferred	274:282	arg1	anticoagulant					284:296	the preferred anticoagulant	270:296	the preferred anticoagulant	270:296	BACKGROUND Venous thromboembolism (VTE) is a complication of cancer, for which low-molecular-weight heparin (LMWH) remains the preferred anticoagulant.
33455432	8	6	theme	patients	1203:1210	arg1	%					1217:1217	42.5%	1213:1217	42.5%	1213:1217	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	8	6	theme	patients	1203:1210	arg1	166					1192:1194	166	1192:1194	166	1192:1194	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	8	6	theme	patients	1203:1210	arg1	patients					1203:1210	391 patients	1199:1210	391 patients (42.5%) in the weight-based cohort (hazard ratio [HR]	1199:1264	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	8	7	theme	hazard	1248:1253	arg1	[HR					1261:1263	hazard ratio [HR	1248:1263	hazard ratio [HR	1248:1263	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	8	7	theme	hazard	1248:1253	arg1	cohort					1240:1245	the weight-based cohort	1223:1245	the weight-based cohort (hazard ratio [HR]	1223:1264	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	12	8	theme	significant	1831:1841	arg1	difference					1843:1852	no significant difference	1828:1852	no significant difference	1828:1852	CONCLUSION AND RELEVANCE Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed.
33455432	8	9	theme	Recurrent	1081:1089	arg1	VTE					1091:1093	Recurrent VTE	1081:1093	Recurrent VTE	1081:1093	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	5	10	dep	OBJECTIVE	594:602	arg1	aims					615:618	aims	615:618	aims to evaluate efficacy (recurrent VTE) and safety (major bleed) between enoxaparin anti-Xa-guided dose adjustments and weight-based dosing in patients with cancer-associated VTE	615:794	OBJECTIVE This study aims to evaluate efficacy (recurrent VTE) and safety (major bleed) between enoxaparin anti-Xa-guided dose adjustments and weight-based dosing in patients with cancer-associated VTE.
33455432	6	11	theme	cohort	839:844	arg1	study					846:850	This single-center, retrospective cohort study	805:850	study	846:850	METHODS This single-center, retrospective cohort study examined patients treated with enoxaparin for cancer-associated VTE using data from electronic health records.
33455432	0	12	theme	Efficacy	137:144	arg1	Evaluation					112:121	A Retrospective Evaluation	96:121	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.	0:145	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.
33455432	10	13	theme	anti-Xa	1508:1514	arg1	levels					1521:1526	1584 anti-Xa peak levels	1503:1526	1584 anti-Xa peak levels	1503:1526	In the anti-Xa cohort, a total of 1584 anti-Xa peak levels were collected, with 1324 (83.6%) drawn correctly in relation to enoxaparin administration.
33455432	12	14	contain	had	1824:1826	arg1	Patients					1698:1705	CONCLUSION AND RELEVANCE Patients	1673:1705	CONCLUSION AND RELEVANCE Patients with cancer	1673:1717	CONCLUSION AND RELEVANCE Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed.
33455432	12	14	contain	had	1824:1826	arg2	difference					1843:1852	no significant difference	1828:1852	no significant difference	1828:1852	CONCLUSION AND RELEVANCE Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed.
33455432	11	15	theme	therapeutic	1654:1664	arg1	range					1666:1670	therapeutic range	1654:1670	therapeutic range	1654:1670	Of those, 714 (53.9%) were within therapeutic range.
33455432	5	16	theme	dose	716:719	arg1	adjustments					721:731	enoxaparin anti-Xa-guided dose adjustments	690:731	enoxaparin anti-Xa-guided dose adjustments	690:731	OBJECTIVE This study aims to evaluate efficacy (recurrent VTE) and safety (major bleed) between enoxaparin anti-Xa-guided dose adjustments and weight-based dosing in patients with cancer-associated VTE.
33455432	5	17	from	efficacy	632:639	arg1	patients					760:767	patients	760:767	patients with cancer-associated VTE	760:794	OBJECTIVE This study aims to evaluate efficacy (recurrent VTE) and safety (major bleed) between enoxaparin anti-Xa-guided dose adjustments and weight-based dosing in patients with cancer-associated VTE.
33455432	1	18	theme	Venous	158:163	arg1	complication					192:203	a complication	190:203	a complication	190:203	BACKGROUND Venous thromboembolism (VTE) is a complication of cancer, for which low-molecular-weight heparin (LMWH) remains the preferred anticoagulant.
33455432	1	18	theme	Venous	158:163	arg1	VTE					182:184	VTE	182:184	VTE	182:184	BACKGROUND Venous thromboembolism (VTE) is a complication of cancer, for which low-molecular-weight heparin (LMWH) remains the preferred anticoagulant.
33455432	1	18	theme	Venous	158:163	arg1	thromboembolism					165:179	BACKGROUND Venous thromboembolism	147:179	BACKGROUND Venous thromboembolism (VTE)	147:185	BACKGROUND Venous thromboembolism (VTE) is a complication of cancer, for which low-molecular-weight heparin (LMWH) remains the preferred anticoagulant.
33455432	3	19	theme	certain	350:356	arg1	populations					358:368	certain populations	350:368	certain populations	350:368	In certain populations, monitoring anti-Xa levels for therapeutic effect provides pharmacokinetic guidance for dose adjustments.
33455432	7	20	theme	anti-Xa-directed	1046:1061	arg1	adjustments					1068:1078	283 receiving anti-Xa-directed dose adjustments	1032:1078	283 receiving anti-Xa-directed dose adjustments	1032:1078	RESULTS There were 674 patients who met the inclusion criteria, with 283 receiving anti-Xa-directed dose adjustments.
33455432	9	21	theme	=	1450:1450	arg1	HR					1447:1448	HR	1447:1448	HR = 1.18	1447:1455	When death was removed from the composite end point, there was no significant difference between the cohorts in recurrent VTE or major bleed (HR = 1.18; P = 0.38).
33455432	3	22	theme	anti-Xa	382:388	arg1	levels					390:395	monitoring anti-Xa levels	371:395	monitoring anti-Xa levels for therapeutic effect	371:418	In certain populations, monitoring anti-Xa levels for therapeutic effect provides pharmacokinetic guidance for dose adjustments.
33455432	9	23	dep	bleed	1440:1444	arg1	=					1460:1460	=	1460:1460	=	1460:1460	When death was removed from the composite end point, there was no significant difference between the cohorts in recurrent VTE or major bleed (HR = 1.18; P = 0.38).
33455432	5	24	theme	cancer-associated	774:790	arg1	VTE					792:794	cancer-associated VTE	774:794	cancer-associated VTE	774:794	OBJECTIVE This study aims to evaluate efficacy (recurrent VTE) and safety (major bleed) between enoxaparin anti-Xa-guided dose adjustments and weight-based dosing in patients with cancer-associated VTE.
33455432	0	25	theme	Safety	126:131	arg1	Evaluation					112:121	A Retrospective Evaluation	96:121	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.	0:145	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.
33455432	12	26	theme	dose	1755:1758	arg1	adjustments					1760:1770	anti-Xa-guided enoxaparin dose adjustments	1729:1770	anti-Xa-guided enoxaparin dose adjustments for initial VTE	1729:1786	CONCLUSION AND RELEVANCE Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed.
33455432	7	27	theme	inclusion	1007:1015	arg1	criteria					1017:1024	the inclusion criteria	1003:1024	the inclusion criteria	1003:1024	RESULTS There were 674 patients who met the inclusion criteria, with 283 receiving anti-Xa-directed dose adjustments.
33455432	12	28	theme	recurrent	1869:1877	arg1	VTE					1879:1881	recurrent VTE	1869:1881	recurrent VTE	1869:1881	CONCLUSION AND RELEVANCE Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed.
33455432	4	29	theme	enoxaparin	530:539	arg1	dosing					541:546	anti-Xa-directed enoxaparin dosing	513:546	anti-Xa-directed enoxaparin dosing for treatment of VTE in patients with cancer	513:591	There is a paucity of data regarding anti-Xa-directed enoxaparin dosing for treatment of VTE in patients with cancer.
33455432	0	30	theme	Cancer-Associated	0:16	arg1	Thromboembolism					25:39	Cancer-Associated Venous Thromboembolism	0:39	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.	0:145	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.
33455432	0	31	theme	Thromboembolism	25:39	arg1	Treatment					41:49	Cancer-Associated Venous Thromboembolism Treatment	0:49	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.	0:145	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.
33455432	6	32	theme	health	947:952	arg1	records					954:960	electronic health records	936:960	electronic health records	936:960	METHODS This single-center, retrospective cohort study examined patients treated with enoxaparin for cancer-associated VTE using data from electronic health records.
33455432	5	33	with	patients	760:767	arg1	VTE					792:794	cancer-associated VTE	774:794	cancer-associated VTE	774:794	OBJECTIVE This study aims to evaluate efficacy (recurrent VTE) and safety (major bleed) between enoxaparin anti-Xa-guided dose adjustments and weight-based dosing in patients with cancer-associated VTE.
33455432	12	34	theme	anti-Xa-guided	1729:1742	arg1	adjustments					1760:1770	anti-Xa-guided enoxaparin dose adjustments	1729:1770	anti-Xa-guided enoxaparin dose adjustments for initial VTE	1729:1786	CONCLUSION AND RELEVANCE Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed.
33455432	3	35	theme	pharmacokinetic	429:443	arg1	guidance					445:452	pharmacokinetic guidance	429:452	pharmacokinetic guidance for dose adjustments	429:473	In certain populations, monitoring anti-Xa levels for therapeutic effect provides pharmacokinetic guidance for dose adjustments.
33455432	6	36	theme	single-center	810:822	arg1	study					846:850	This single-center, retrospective cohort study	805:850	study	846:850	METHODS This single-center, retrospective cohort study examined patients treated with enoxaparin for cancer-associated VTE using data from electronic health records.
33455432	8	37	theme	patients	1151:1158	arg1	patients					1151:1158	283 patients	1147:1158	283 patients (36%)	1147:1164	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	8	37	theme	patients	1151:1158	arg1	%					1163:1163	36%	1161:1163	36%	1161:1163	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	8	37	theme	patients	1151:1158	arg1	102					1140:1142	102	1140:1142	102	1140:1142	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	8	38	from	patients	1203:1210	arg1	[HR					1261:1263	hazard ratio [HR	1248:1263	hazard ratio [HR	1248:1263	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	8	38	from	patients	1203:1210	arg1	cohort					1240:1245	the weight-based cohort	1223:1245	the weight-based cohort (hazard ratio [HR]	1223:1264	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	12	39	theme	CONCLUSION	1673:1682	arg1	Patients					1698:1705	CONCLUSION AND RELEVANCE Patients	1673:1705	CONCLUSION AND RELEVANCE Patients with cancer	1673:1717	CONCLUSION AND RELEVANCE Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed.
33455432	1	40	theme	low-molecular-weight	226:245	arg1	LMWH					256:259	LMWH	256:259	LMWH	256:259	BACKGROUND Venous thromboembolism (VTE) is a complication of cancer, for which low-molecular-weight heparin (LMWH) remains the preferred anticoagulant.
33455432	1	40	theme	low-molecular-weight	226:245	arg1	heparin					247:253	low-molecular-weight heparin	226:253	low-molecular-weight heparin (LMWH)	226:260	BACKGROUND Venous thromboembolism (VTE) is a complication of cancer, for which low-molecular-weight heparin (LMWH) remains the preferred anticoagulant.
33455432	6	41	theme	cancer-associated	898:914	arg1	VTE					916:918	cancer-associated VTE	898:918	cancer-associated VTE	898:918	METHODS This single-center, retrospective cohort study examined patients treated with enoxaparin for cancer-associated VTE using data from electronic health records.
33455432	10	42	theme	enoxaparin	1593:1602	arg1	administration					1604:1617	enoxaparin administration	1593:1617	enoxaparin administration	1593:1617	In the anti-Xa cohort, a total of 1584 anti-Xa peak levels were collected, with 1324 (83.6%) drawn correctly in relation to enoxaparin administration.
33455432	9	43	theme	end	1347:1349	arg1	point					1351:1355	the composite end point	1333:1355	the composite end point	1333:1355	When death was removed from the composite end point, there was no significant difference between the cohorts in recurrent VTE or major bleed (HR = 1.18; P = 0.38).
33455432	12	44	theme	VTE	1879:1881	arg1	rate					1861:1864	the rate	1857:1864	the rate of recurrent VTE	1857:1881	CONCLUSION AND RELEVANCE Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed.
33455432	9	45	attach	removed	1320:1326	arg1	point					1351:1355	the composite end point	1333:1355	the composite end point	1333:1355	When death was removed from the composite end point, there was no significant difference between the cohorts in recurrent VTE or major bleed (HR = 1.18; P = 0.38).
33455432	9	45	attach	removed	1320:1326	arg2	death					1310:1314	death	1310:1314	death	1310:1314	When death was removed from the composite end point, there was no significant difference between the cohorts in recurrent VTE or major bleed (HR = 1.18; P = 0.38).
33455432	10	46	theme	anti-Xa	1476:1482	arg1	cohort					1484:1489	the anti-Xa cohort	1472:1489	the anti-Xa cohort	1472:1489	In the anti-Xa cohort, a total of 1584 anti-Xa peak levels were collected, with 1324 (83.6%) drawn correctly in relation to enoxaparin administration.
33455432	4	47	from	treatment	552:560	arg1	patients					572:579	patients	572:579	patients with cancer	572:591	There is a paucity of data regarding anti-Xa-directed enoxaparin dosing for treatment of VTE in patients with cancer.
33455432	9	48	theme	significant	1371:1381	arg1	difference					1383:1392	no significant difference	1368:1392	no significant difference between the cohorts in recurrent VTE or major bleed (HR = 1.18; P = 0.38)	1368:1466	When death was removed from the composite end point, there was no significant difference between the cohorts in recurrent VTE or major bleed (HR = 1.18; P = 0.38).
33455432	8	49	theme	ratio	1255:1259	arg1	[HR					1261:1263	hazard ratio [HR	1248:1263	hazard ratio [HR	1248:1263	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	8	49	theme	ratio	1255:1259	arg1	cohort					1240:1245	the weight-based cohort	1223:1245	the weight-based cohort (hazard ratio [HR]	1223:1264	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	7	50	dep	RESULTS	963:969	arg1	were					977:980	were	977:980	were	977:980	RESULTS There were 674 patients who met the inclusion criteria, with 283 receiving anti-Xa-directed dose adjustments.
33455432	5	51	theme	weight-based	737:748	arg1	dosing					750:755	weight-based dosing	737:755	weight-based dosing	737:755	OBJECTIVE This study aims to evaluate efficacy (recurrent VTE) and safety (major bleed) between enoxaparin anti-Xa-guided dose adjustments and weight-based dosing in patients with cancer-associated VTE.
33455432	6	52	theme	retrospective	825:837	arg1	study					846:850	This single-center, retrospective cohort study	805:850	study	846:850	METHODS This single-center, retrospective cohort study examined patients treated with enoxaparin for cancer-associated VTE using data from electronic health records.
33455432	4	53	with	patients	572:579	arg1	cancer					586:591	cancer	586:591	cancer	586:591	There is a paucity of data regarding anti-Xa-directed enoxaparin dosing for treatment of VTE in patients with cancer.
33455432	1	54	theme	cancer	208:213	arg1	complication					192:203	a complication	190:203	a complication	190:203	BACKGROUND Venous thromboembolism (VTE) is a complication of cancer, for which low-molecular-weight heparin (LMWH) remains the preferred anticoagulant.
33455432	1	54	theme	cancer	208:213	arg1	thromboembolism					165:179	BACKGROUND Venous thromboembolism	147:179	BACKGROUND Venous thromboembolism (VTE)	147:185	BACKGROUND Venous thromboembolism (VTE) is a complication of cancer, for which low-molecular-weight heparin (LMWH) remains the preferred anticoagulant.
33455432	10	55	theme	peak	1516:1519	arg1	levels					1521:1526	1584 anti-Xa peak levels	1503:1526	1584 anti-Xa peak levels	1503:1526	In the anti-Xa cohort, a total of 1584 anti-Xa peak levels were collected, with 1324 (83.6%) drawn correctly in relation to enoxaparin administration.
33455432	9	56	theme	recurrent	1417:1425	arg1	VTE					1427:1429	recurrent VTE	1417:1429	recurrent VTE	1417:1429	When death was removed from the composite end point, there was no significant difference between the cohorts in recurrent VTE or major bleed (HR = 1.18; P = 0.38).
33455432	12	57	theme	weight-based	1803:1814	arg1	dosing					1816:1821	weight-based dosing	1803:1821	weight-based dosing	1803:1821	CONCLUSION AND RELEVANCE Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed.
33455432	4	58	theme	data	498:501	arg1	paucity					487:493	a paucity	485:493	a paucity of data regarding anti-Xa-directed enoxaparin dosing for treatment of VTE in patients with cancer	485:591	There is a paucity of data regarding anti-Xa-directed enoxaparin dosing for treatment of VTE in patients with cancer.
33455432	5	59	theme	anti-Xa-guided	701:714	arg1	adjustments					721:731	enoxaparin anti-Xa-guided dose adjustments	690:731	enoxaparin anti-Xa-guided dose adjustments	690:731	OBJECTIVE This study aims to evaluate efficacy (recurrent VTE) and safety (major bleed) between enoxaparin anti-Xa-guided dose adjustments and weight-based dosing in patients with cancer-associated VTE.
33455432	8	60	theme	weight-based	1227:1238	arg1	[HR					1261:1263	hazard ratio [HR	1248:1263	hazard ratio [HR	1248:1263	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	8	60	theme	weight-based	1227:1238	arg1	cohort					1240:1245	the weight-based cohort	1223:1245	the weight-based cohort (hazard ratio [HR]	1223:1264	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	7	61	theme	receiving	1036:1044	arg1	adjustments					1068:1078	283 receiving anti-Xa-directed dose adjustments	1032:1078	283 receiving anti-Xa-directed dose adjustments	1032:1078	RESULTS There were 674 patients who met the inclusion criteria, with 283 receiving anti-Xa-directed dose adjustments.
33455432	1	62	theme	BACKGROUND	147:156	arg1	complication					192:203	a complication	190:203	a complication	190:203	BACKGROUND Venous thromboembolism (VTE) is a complication of cancer, for which low-molecular-weight heparin (LMWH) remains the preferred anticoagulant.
33455432	1	62	theme	BACKGROUND	147:156	arg1	VTE					182:184	VTE	182:184	VTE	182:184	BACKGROUND Venous thromboembolism (VTE) is a complication of cancer, for which low-molecular-weight heparin (LMWH) remains the preferred anticoagulant.
33455432	1	62	theme	BACKGROUND	147:156	arg1	thromboembolism					165:179	BACKGROUND Venous thromboembolism	147:179	BACKGROUND Venous thromboembolism (VTE)	147:185	BACKGROUND Venous thromboembolism (VTE) is a complication of cancer, for which low-molecular-weight heparin (LMWH) remains the preferred anticoagulant.
33455432	9	63	dep	=	1460:1460	arg1	HR					1447:1448	HR	1447:1448	HR = 1.18	1447:1455	When death was removed from the composite end point, there was no significant difference between the cohorts in recurrent VTE or major bleed (HR = 1.18; P = 0.38).
33455432	11	64	theme	those	1623:1627	arg1	range					1666:1670	therapeutic range	1654:1670	therapeutic range	1654:1670	Of those, 714 (53.9%) were within therapeutic range.
33455432	0	65	theme	Retrospective	98:110	arg1	Evaluation					112:121	A Retrospective Evaluation	96:121	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.	0:145	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.
33455432	7	66	theme	dose	1063:1066	arg1	adjustments					1068:1078	283 receiving anti-Xa-directed dose adjustments	1032:1078	283 receiving anti-Xa-directed dose adjustments	1032:1078	RESULTS There were 674 patients who met the inclusion criteria, with 283 receiving anti-Xa-directed dose adjustments.
33455432	4	67	theme	VTE	565:567	arg1	treatment					552:560	treatment	552:560	treatment of VTE in patients with cancer	552:591	There is a paucity of data regarding anti-Xa-directed enoxaparin dosing for treatment of VTE in patients with cancer.
33455432	8	68	theme	all-cause	1112:1120	arg1	death					1122:1126	all-cause death	1112:1126	all-cause death	1112:1126	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33455432	5	69	theme	recurrent	642:650	arg1	efficacy					632:639	efficacy	632:639	efficacy (recurrent VTE)	632:655	OBJECTIVE This study aims to evaluate efficacy (recurrent VTE) and safety (major bleed) between enoxaparin anti-Xa-guided dose adjustments and weight-based dosing in patients with cancer-associated VTE.
33455432	5	69	theme	recurrent	642:650	arg1	VTE					652:654	recurrent VTE	642:654	recurrent VTE	642:654	OBJECTIVE This study aims to evaluate efficacy (recurrent VTE) and safety (major bleed) between enoxaparin anti-Xa-guided dose adjustments and weight-based dosing in patients with cancer-associated VTE.
33455432	4	70	theme	anti-Xa-directed	513:528	arg1	dosing					541:546	anti-Xa-directed enoxaparin dosing	513:546	anti-Xa-directed enoxaparin dosing for treatment of VTE in patients with cancer	513:591	There is a paucity of data regarding anti-Xa-directed enoxaparin dosing for treatment of VTE in patients with cancer.
33455432	3	71	theme	monitoring	371:380	arg1	levels					390:395	monitoring anti-Xa levels	371:395	monitoring anti-Xa levels for therapeutic effect	371:418	In certain populations, monitoring anti-Xa levels for therapeutic effect provides pharmacokinetic guidance for dose adjustments.
33455432	0	72	theme	Venous	18:23	arg1	Thromboembolism					25:39	Cancer-Associated Venous Thromboembolism	0:39	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.	0:145	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.
33455432	12	73	theme	initial	1776:1782	arg1	VTE					1784:1786	initial VTE	1776:1786	initial VTE	1776:1786	CONCLUSION AND RELEVANCE Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed.
33455432	10	74	theme	levels	1521:1526	arg1	total					1494:1498	a total	1492:1498	a total of 1584 anti-Xa peak levels	1492:1526	In the anti-Xa cohort, a total of 1584 anti-Xa peak levels were collected, with 1324 (83.6%) drawn correctly in relation to enoxaparin administration.
33455432	3	75	theme	therapeutic	401:411	arg1	effect					413:418	therapeutic effect	401:418	therapeutic effect	401:418	In certain populations, monitoring anti-Xa levels for therapeutic effect provides pharmacokinetic guidance for dose adjustments.
33455432	9	76	dep	=	1450:1450	arg1	1.18					1452:1455	1.18	1452:1455	1.18	1452:1455	When death was removed from the composite end point, there was no significant difference between the cohorts in recurrent VTE or major bleed (HR = 1.18; P = 0.38).
33455432	0	77	theme	Anti-Xa	56:62	arg1	Enoxaparin					84:93	Anti-Xa Versus Weight-Based Enoxaparin	56:93	Anti-Xa Versus Weight-Based Enoxaparin	56:93	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.
33455432	5	78	from	safety	661:666	arg1	patients					760:767	patients	760:767	patients with cancer-associated VTE	760:794	OBJECTIVE This study aims to evaluate efficacy (recurrent VTE) and safety (major bleed) between enoxaparin anti-Xa-guided dose adjustments and weight-based dosing in patients with cancer-associated VTE.
33455432	12	79	theme	enoxaparin	1744:1753	arg1	adjustments					1760:1770	anti-Xa-guided enoxaparin dose adjustments	1729:1770	anti-Xa-guided enoxaparin dose adjustments for initial VTE	1729:1786	CONCLUSION AND RELEVANCE Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed.
33455432	6	80	theme	electronic	936:945	arg1	records					954:960	electronic health records	936:960	electronic health records	936:960	METHODS This single-center, retrospective cohort study examined patients treated with enoxaparin for cancer-associated VTE using data from electronic health records.
33455432	3	81	theme	dose	458:461	arg1	adjustments					463:473	dose adjustments	458:473	dose adjustments	458:473	In certain populations, monitoring anti-Xa levels for therapeutic effect provides pharmacokinetic guidance for dose adjustments.
33455432	0	82	with	Treatment	41:49	arg1	Enoxaparin					84:93	Anti-Xa Versus Weight-Based Enoxaparin	56:93	Anti-Xa Versus Weight-Based Enoxaparin	56:93	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.
33455432	0	83	theme	Weight-Based	71:82	arg1	Enoxaparin					84:93	Anti-Xa Versus Weight-Based Enoxaparin	56:93	Anti-Xa Versus Weight-Based Enoxaparin	56:93	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.
33455432	12	84	theme	RELEVANCE	1688:1696	arg1	Patients					1698:1705	CONCLUSION AND RELEVANCE Patients	1673:1705	CONCLUSION AND RELEVANCE Patients with cancer	1673:1717	CONCLUSION AND RELEVANCE Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed.
33455432	5	85	dep	safety	661:666	arg1	bleed					675:679	bleed	675:679	bleed	675:679	OBJECTIVE This study aims to evaluate efficacy (recurrent VTE) and safety (major bleed) between enoxaparin anti-Xa-guided dose adjustments and weight-based dosing in patients with cancer-associated VTE.
33455432	0	86	dep	Treatment	41:49	arg1	Evaluation					112:121	A Retrospective Evaluation	96:121	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.	0:145	Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.
33455432	9	87	theme	composite	1337:1345	arg1	point					1351:1355	the composite end point	1333:1355	the composite end point	1333:1355	When death was removed from the composite end point, there was no significant difference between the cohorts in recurrent VTE or major bleed (HR = 1.18; P = 0.38).
33455432	8	88	theme	anti-Xa	1173:1179	arg1	cohort					1181:1186	the anti-Xa cohort	1169:1186	the anti-Xa cohort	1169:1186	Recurrent VTE, major bleed, or all-cause death occurred in 102 of 283 patients (36%) in the anti-Xa cohort and 166 of 391 patients (42.5%) in the weight-based cohort (hazard ratio [HR] = 0.73; 95% CI = 0.57-0.93; P = 0.01).
33436218	1	0	theme	gel-filtration	330:343	arg1	chromatography					352:365	gel-filtration column chromatography	330:365	gel-filtration column chromatography	330:365	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa was purified from brown algae Sargassum henslowianum using ethanol precipitation, ion-exchange chromatography, and gel-filtration column chromatography.
33436218	2	1	dep	β-D-	469:472	arg1	1→3					474:476	1→3	474:476	1→3	474:476	Structural analyses reveal that SHNP is completely composed of glucose, and its backbone consists of β-D-(1→3)-Glcp with side chains comprising t-β-D-Glcp attached at the O-6 position.
33436218	2	2	theme	Structural	368:377	arg1	analyses					379:386	Structural analyses	368:386	Structural analyses	368:386	Structural analyses reveal that SHNP is completely composed of glucose, and its backbone consists of β-D-(1→3)-Glcp with side chains comprising t-β-D-Glcp attached at the O-6 position.
33436218	1	3	theme	column	345:350	arg1	chromatography					352:365	gel-filtration column chromatography	330:365	gel-filtration column chromatography	330:365	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa was purified from brown algae Sargassum henslowianum using ethanol precipitation, ion-exchange chromatography, and gel-filtration column chromatography.
33436218	4	4	dep	In	600:601	arg1	vitro					603:607	vitro	603:607	vitro	603:607	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	2	5	with	-Glcp	478:482	arg1	chains					494:499	side chains	489:499	side chains comprising t-β-D-Glcp attached at the O-6 position	489:550	Structural analyses reveal that SHNP is completely composed of glucose, and its backbone consists of β-D-(1→3)-Glcp with side chains comprising t-β-D-Glcp attached at the O-6 position.
33436218	1	6	theme	homogeneous	135:145	arg1	polysaccharide					147:160	A homogeneous polysaccharide	133:160	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa	133:213	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa was purified from brown algae Sargassum henslowianum using ethanol precipitation, ion-exchange chromatography, and gel-filtration column chromatography.
33436218	1	7	theme	brown	233:237	arg1	algae					239:243	brown algae	233:243	brown algae	233:243	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa was purified from brown algae Sargassum henslowianum using ethanol precipitation, ion-exchange chromatography, and gel-filtration column chromatography.
33436218	0	8	from	Structure	0:8	arg1	henslowianum					72:83	brown algae Sargassum henslowianum	50:83	brown algae Sargassum henslowianum	50:83	Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.
33436218	5	9	theme	species	953:959	arg1	growth					943:948	the growth	939:948	the growth of species belonging to Enterobacteriaceae	939:991	Furthermore, SHNP regulated the intestinal microbiota composition by stimulating the growth of species belonging to Enterobacteriaceae while depleting Haemophilus parainfluenzae and Gemmiger formicilis.
33436218	4	10	theme	test	622:625	arg1	results					627:633	In vitro fermentation test results	600:633	In vitro fermentation test results	600:633	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	6	11	from	role	1176:1179	arg1	regulation					1188:1197	the regulation	1184:1197	the regulation	1184:1197	Taken together, these results indicate that SHNP has the potential for regulating gut microbiota, but its specific role in the regulation requires to be further investigated.
33436218	1	12	theme	polysaccharide	147:160	arg1	SHNP					168:171	A homogeneous polysaccharide named SHNP	133:171	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa	133:213	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa was purified from brown algae Sargassum henslowianum using ethanol precipitation, ion-exchange chromatography, and gel-filtration column chromatography.
33436218	1	13	theme	named	162:166	arg1	SHNP					168:171	A homogeneous polysaccharide named SHNP	133:171	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa	133:213	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa was purified from brown algae Sargassum henslowianum using ethanol precipitation, ion-exchange chromatography, and gel-filtration column chromatography.
33436218	6	14	theme	specific	1167:1174	arg1	role					1176:1179	its specific role	1163:1179	its specific role in the regulation	1163:1197	Taken together, these results indicate that SHNP has the potential for regulating gut microbiota, but its specific role in the regulation requires to be further investigated.
33436218	4	15	theme	n-butyric	812:820	arg1	acids					822:826	n-butyric acids	812:826	n-butyric acids	812:826	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	4	16	theme	fecal	704:708	arg1	culture					710:716	the fecal culture	700:716	the fecal culture of SHNP	700:724	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	0	17	theme	laminarin-type	15:28	arg1	-glucan					37:43	a laminarin-type β-(1→3)-glucan	13:43	a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum	13:83	Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.
33436218	4	18	theme	SHNP	721:724	arg1	culture					710:716	the fecal culture	700:716	the fecal culture of SHNP	700:724	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	1	19	theme	apparent	178:185	arg1	weight					197:202	apparent molecular weight	178:202	apparent molecular weight of 8.4 kDa	178:213	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa was purified from brown algae Sargassum henslowianum using ethanol precipitation, ion-exchange chromatography, and gel-filtration column chromatography.
33436218	1	20	theme	ethanol	274:280	arg1	precipitation					282:294	ethanol precipitation	274:294	ethanol precipitation	274:294	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa was purified from brown algae Sargassum henslowianum using ethanol precipitation, ion-exchange chromatography, and gel-filtration column chromatography.
33436218	2	21	theme	O-6	539:541	arg1	position					543:550	the O-6 position	535:550	the O-6 position	535:550	Structural analyses reveal that SHNP is completely composed of glucose, and its backbone consists of β-D-(1→3)-Glcp with side chains comprising t-β-D-Glcp attached at the O-6 position.
33436218	1	22	theme	molecular	187:195	arg1	weight					197:202	apparent molecular weight	178:202	apparent molecular weight of 8.4 kDa	178:213	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa was purified from brown algae Sargassum henslowianum using ethanol precipitation, ion-exchange chromatography, and gel-filtration column chromatography.
33436218	5	23	theme	intestinal	890:899	arg1	composition					912:922	the intestinal microbiota composition	886:922	the intestinal microbiota composition	886:922	Furthermore, SHNP regulated the intestinal microbiota composition by stimulating the growth of species belonging to Enterobacteriaceae while depleting Haemophilus parainfluenzae and Gemmiger formicilis.
33436218	0	24	theme	gut	117:119	arg1	microbiota					121:130	gut microbiota	117:130	gut microbiota	117:130	Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.
33436218	6	25	theme	gut	1143:1145	arg1	microbiota					1147:1156	gut microbiota	1143:1156	gut microbiota	1143:1156	Taken together, these results indicate that SHNP has the potential for regulating gut microbiota, but its specific role in the regulation requires to be further investigated.
33436218	3	26	theme	laminarin-type	569:582	arg1	polysaccharide					584:597	a laminarin-type polysaccharide	567:597	a laminarin-type polysaccharide	567:597	Thus, SHNP is a laminarin-type polysaccharide.
33436218	3	26	theme	laminarin-type	569:582	arg1	SHNP					559:562	SHNP	559:562	SHNP	559:562	Thus, SHNP is a laminarin-type polysaccharide.
33436218	0	27	theme	β-	30:31	arg1	-glucan					37:43	a laminarin-type β-(1→3)-glucan	13:43	a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum	13:83	Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.
33436218	2	28	theme	β-D-	469:472	arg1	-Glcp					478:482	β-D-(1→3)-Glcp	469:482	β-D-(1→3)-Glcp with side chains comprising t-β-D-Glcp attached at the O-6 position	469:550	Structural analyses reveal that SHNP is completely composed of glucose, and its backbone consists of β-D-(1→3)-Glcp with side chains comprising t-β-D-Glcp attached at the O-6 position.
33436218	1	29	theme	ion-exchange	297:308	arg1	chromatography					310:323	ion-exchange chromatography	297:323	ion-exchange chromatography	297:323	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa was purified from brown algae Sargassum henslowianum using ethanol precipitation, ion-exchange chromatography, and gel-filtration column chromatography.
33436218	1	30	with	SHNP	168:171	arg1	weight					197:202	apparent molecular weight	178:202	apparent molecular weight of 8.4 kDa	178:213	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa was purified from brown algae Sargassum henslowianum using ethanol precipitation, ion-exchange chromatography, and gel-filtration column chromatography.
33436218	2	31	attach	attached	523:530	arg2	t-β-D-Glcp					512:521	t-β-D-Glcp	512:521	t-β-D-Glcp attached at the O-6 position	512:550	Structural analyses reveal that SHNP is completely composed of glucose, and its backbone consists of β-D-(1→3)-Glcp with side chains comprising t-β-D-Glcp attached at the O-6 position.
33436218	2	31	attach	attached	523:530	arg3	position					543:550	the O-6 position	535:550	the O-6 position	535:550	Structural analyses reveal that SHNP is completely composed of glucose, and its backbone consists of β-D-(1→3)-Glcp with side chains comprising t-β-D-Glcp attached at the O-6 position.
33436218	0	32	theme	1→3	33:35	arg1	-glucan					37:43	a laminarin-type β-(1→3)-glucan	13:43	a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum	13:83	Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.
33436218	4	33	dep	acetic	790:795	arg1	propionic					798:806	propionic	798:806	propionic	798:806	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	4	34	theme	acetic	790:795	arg1	acids					783:787	total short-chain fatty acids	759:787	total short-chain fatty acids	759:787	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	4	35	theme	pH	688:689	arg1	value					691:695	the pH value	684:695	the pH value in the fecal culture of SHNP	684:724	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	6	36	contain	has	1110:1112	arg1	SHNP					1105:1108	SHNP	1105:1108	SHNP	1105:1108	Taken together, these results indicate that SHNP has the potential for regulating gut microbiota, but its specific role in the regulation requires to be further investigated.
33436218	6	36	contain	has	1110:1112	arg2	potential					1118:1126	the potential	1114:1126	the potential for regulating gut microbiota	1114:1156	Taken together, these results indicate that SHNP has the potential for regulating gut microbiota, but its specific role in the regulation requires to be further investigated.
33436218	4	37	theme	total	759:763	arg1	acids					783:787	total short-chain fatty acids	759:787	total short-chain fatty acids	759:787	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	5	38	theme	microbiota	901:910	arg1	composition					912:922	the intestinal microbiota composition	886:922	the intestinal microbiota composition	886:922	Furthermore, SHNP regulated the intestinal microbiota composition by stimulating the growth of species belonging to Enterobacteriaceae while depleting Haemophilus parainfluenzae and Gemmiger formicilis.
33436218	4	39	theme	In	600:601	arg1	results					627:633	In vitro fermentation test results	600:633	In vitro fermentation test results	600:633	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	0	40	from	henslowianum	72:83	arg1	Structure					0:8	Structure	0:8	Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum	0:83	Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.
33436218	0	40	from	henslowianum	72:83	arg1	potential					93:101	its potential	89:101	its potential on regulating gut microbiota	89:130	Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.
33436218	0	40	from	henslowianum	72:83	arg1	-glucan					37:43	a laminarin-type β-(1→3)-glucan	13:43	a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum	13:83	Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.
33436218	4	41	from	value	691:695	arg1	culture					710:716	the fecal culture	700:716	the fecal culture of SHNP	700:724	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	1	42	theme	kDa	211:213	arg1	weight					197:202	apparent molecular weight	178:202	apparent molecular weight of 8.4 kDa	178:213	A homogeneous polysaccharide named SHNP with apparent molecular weight of 8.4 kDa was purified from brown algae Sargassum henslowianum using ethanol precipitation, ion-exchange chromatography, and gel-filtration column chromatography.
33436218	2	43	theme	side	489:492	arg1	chains					494:499	side chains	489:499	side chains comprising t-β-D-Glcp attached at the O-6 position	489:550	Structural analyses reveal that SHNP is completely composed of glucose, and its backbone consists of β-D-(1→3)-Glcp with side chains comprising t-β-D-Glcp attached at the O-6 position.
33436218	4	44	theme	fatty	777:781	arg1	acids					783:787	total short-chain fatty acids	759:787	total short-chain fatty acids	759:787	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	4	45	theme	fermentation	609:620	arg1	results					627:633	In vitro fermentation test results	600:633	In vitro fermentation test results	600:633	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	0	46	theme	-glucan	37:43	arg1	Structure					0:8	Structure	0:8	Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum	0:83	Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.
33436218	0	46	theme	-glucan	37:43	arg1	potential					93:101	its potential	89:101	its potential on regulating gut microbiota	89:130	Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.
33436218	4	47	theme	short-chain	765:775	arg1	acids					783:787	total short-chain fatty acids	759:787	total short-chain fatty acids	759:787	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	4	48	theme	gut	668:670	arg1	microbiota					672:681	gut microbiota	668:681	gut microbiota	668:681	In vitro fermentation test results showed that SHNP was digested by gut microbiota; the pH value in the fecal culture of SHNP was significantly decreased; and total short-chain fatty acids, acetic, propionic and n-butyric acids were significantly increased.
33436218	0	49	from	potential	93:101	arg1	henslowianum					72:83	brown algae Sargassum henslowianum	50:83	brown algae Sargassum henslowianum	50:83	Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota.
33430198	8	0	theme	tissue	1825:1830	arg1	growth					1810:1815	excessive growth	1800:1815	excessive growth of bone tissue and material displacement beyond the defect	1800:1874	Implantation of the material with 50 μg/mL BMP-2 was accompanied with excessive growth of bone tissue and material displacement beyond the defect.
33430198	1	1	theme	moldable	312:319	arg1	materials					332:340	moldable bone graft materials	312:340	moldable bone graft materials that have osteoinductive and osteoconductive properties	312:396	Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties.
33430198	8	2	theme	material	1836:1843	arg1	displacement					1845:1856	material displacement	1836:1856	material displacement	1836:1856	Implantation of the material with 50 μg/mL BMP-2 was accompanied with excessive growth of bone tissue and material displacement beyond the defect.
33430198	5	3	with	filling	1153:1159	arg1	%					1222:1222	more than 20%	1210:1222	more than 20%	1210:1222	Excessive filling of the material with PLA (polylactide) granules (more than 20%) led to material destruction at a ~10% strain.
33430198	5	3	with	filling	1153:1159	arg1	granules					1200:1207	PLA (polylactide) granules	1182:1207	PLA (polylactide) granules (more than 20%)	1182:1223	Excessive filling of the material with PLA (polylactide) granules (more than 20%) led to material destruction at a ~10% strain.
33430198	1	4	contain	have	347:350	arg1	materials					332:340	moldable bone graft materials	312:340	moldable bone graft materials that have osteoinductive and osteoconductive properties	312:396	Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties.
33430198	1	4	contain	have	347:350	arg2	properties					387:396	osteoinductive and osteoconductive properties	352:396	osteoinductive and osteoconductive properties	352:396	Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties.
33430198	1	5	theme	graft	326:330	arg1	materials					332:340	moldable bone graft materials	312:340	moldable bone graft materials that have osteoinductive and osteoconductive properties	312:396	Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties.
33430198	8	6	theme	50	1764:1765	arg1	μg/mL					1767:1771	μg/mL	1767:1771	μg/mL	1767:1771	Implantation of the material with 50 μg/mL BMP-2 was accompanied with excessive growth of bone tissue and material displacement beyond the defect.
33430198	9	7	theme	osteoinductive	1889:1902	arg1	properties					1924:1933	Significant osteoinductive and osteoconductive properties	1877:1933	Significant osteoinductive and osteoconductive properties of the material with 10 μg/mL of BMP-2	1877:1972	Significant osteoinductive and osteoconductive properties of the material with 10 μg/mL of BMP-2 were also shown in subcutaneous implantation.
33430198	3	8	theme	DD	725:726	arg1	%					727:727	a reduced DD%	715:727	a reduced DD%	715:727	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	3	9	with	hydrogel	689:696	arg1	chitosan					703:710	chitosan	703:710	chitosan of a reduced DD%	703:727	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	1	10	theme	chitosan/β-glycerophosphate	212:238	arg1	hydrogels					240:248	chitosan/β-glycerophosphate hydrogels	212:248	chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules	212:288	Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties.
33430198	0	11	theme	Hydrogels	179:187	arg1	Properties					112:121	Biocompatibility and Osteogenic Properties	80:121	Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels	80:187	Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels.
33430198	7	12	theme	optimal	1627:1633	arg1	μg/mL					1665:1669	10 μg/mL	1662:1669	10 μg/mL	1662:1669	When implanted into a critical-size calvarial defect in rats, the optimal concentration of BMP-2 was 10 μg/mL: bone tissue areas filled the entire material's thickness.
33430198	7	12	theme	optimal	1627:1633	arg1	concentration					1635:1647	the optimal concentration	1623:1647	the optimal concentration of BMP-2	1623:1656	When implanted into a critical-size calvarial defect in rats, the optimal concentration of BMP-2 was 10 μg/mL: bone tissue areas filled the entire material's thickness.
33430198	4	13	theme	hydrogel-based	1091:1104	arg1	material					1106:1113	the hydrogel-based material	1087:1113	the hydrogel-based material	1087:1113	The addition of 12 wt% polylactide granules resulted in optimal composite mechanical and moldable properties, and increased the modulus of elasticity of the hydrogel-based material by approximately 100 times.
33430198	1	14	theme	porous	262:267	arg1	granules					281:288	highly porous polylactide granules	255:288	highly porous polylactide granules	255:288	Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties.
33430198	9	15	theme	material	1942:1949	arg1	properties					1924:1933	Significant osteoinductive and osteoconductive properties	1877:1933	Significant osteoinductive and osteoconductive properties of the material with 10 μg/mL of BMP-2	1877:1972	Significant osteoinductive and osteoconductive properties of the material with 10 μg/mL of BMP-2 were also shown in subcutaneous implantation.
33430198	0	16	theme	Granule-Loaded	136:149	arg1	Hydrogels					179:187	BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels	126:187	BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels	126:187	Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels.
33430198	6	17	theme	porous	1404:1409	arg1	granules					1423:1430	highly porous polylactide granules	1397:1430	highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2)	1397:1484	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	5	18	from	strain	1263:1268	arg1	destruction					1241:1251	material destruction	1232:1251	material destruction at a ~10% strain	1232:1268	Excessive filling of the material with PLA (polylactide) granules (more than 20%) led to material destruction at a ~10% strain.
33430198	3	19	theme	deacetylation	757:769	arg1	degree					747:752	a low degree	741:752	a low degree of deacetylation	741:769	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	6	20	theme	Osteoinductive	1271:1284	arg1	properties					1306:1315	Osteoinductive and osteoconductive properties	1271:1315	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2)	1271:1484	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	7	21	theme	calvarial	1597:1605	arg1	defect					1607:1612	a critical-size calvarial defect	1581:1612	a critical-size calvarial defect in rats	1581:1620	When implanted into a critical-size calvarial defect in rats, the optimal concentration of BMP-2 was 10 μg/mL: bone tissue areas filled the entire material's thickness.
33430198	3	22	theme	stromal	803:809	arg1	cells					811:815	multipotent stromal cells	791:815	multipotent stromal cells	791:815	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	3	22	theme	stromal	803:809	arg1	MSCs					785:788	the MSCs	781:788	the MSCs (multipotent stromal cells) viability rate	781:831	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	7	23	theme	entire	1701:1706	arg1	thickness					1719:1727	the entire material's thickness	1697:1727	the entire material's thickness	1697:1727	When implanted into a critical-size calvarial defect in rats, the optimal concentration of BMP-2 was 10 μg/mL: bone tissue areas filled the entire material's thickness.
33430198	4	24	theme	polylactide	957:967	arg1	granules					969:976	12 wt% polylactide granules	950:976	12 wt% polylactide granules	950:976	The addition of 12 wt% polylactide granules resulted in optimal composite mechanical and moldable properties, and increased the modulus of elasticity of the hydrogel-based material by approximately 100 times.
33430198	5	25	theme	%	1261:1261	arg1	strain					1263:1268	a ~10% strain	1256:1268	a ~10% strain	1256:1268	Excessive filling of the material with PLA (polylactide) granules (more than 20%) led to material destruction at a ~10% strain.
33430198	6	26	theme	bone	1545:1548	arg1	formation					1550:1558	orthotopic and ectopic bone formation	1522:1558	formation	1550:1558	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	2	27	theme	chitosan	550:557	arg1	sample					559:564	the one-stock chitosan sample	536:564	the one-stock chitosan sample	536:564	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	6	28	theme	reacetylated	1362:1373	arg1	chitosan					1375:1382	reacetylated chitosan	1362:1382	reacetylated chitosan (39 DD%)	1362:1391	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	6	28	theme	reacetylated	1362:1373	arg1	%					1390:1390	39 DD%	1385:1390	39 DD%	1385:1390	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	3	29	theme	leukocyte	858:866	arg1	infiltration					868:879	the leukocyte infiltration	854:879	the leukocyte infiltration in subcutaneous implantation to Wistar rats	854:923	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	0	30	from	Influence	0:8	arg1	Properties					112:121	Biocompatibility and Osteogenic Properties	80:121	Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels	80:187	Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels.
33430198	9	31	theme	subcutaneous	1993:2004	arg1	implantation					2006:2017	subcutaneous implantation	1993:2017	subcutaneous implantation	1993:2017	Significant osteoinductive and osteoconductive properties of the material with 10 μg/mL of BMP-2 were also shown in subcutaneous implantation.
33430198	0	32	theme	Biocompatibility	80:95	arg1	Properties					112:121	Biocompatibility and Osteogenic Properties	80:121	Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels	80:187	Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels.
33430198	3	33	theme	Wistar	913:918	arg1	rats					920:923	Wistar rats	913:923	Wistar rats	913:923	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	4	34	theme	wt	953:954	arg1	granules					969:976	12 wt% polylactide granules	950:976	12 wt% polylactide granules	950:976	The addition of 12 wt% polylactide granules resulted in optimal composite mechanical and moldable properties, and increased the modulus of elasticity of the hydrogel-based material by approximately 100 times.
33430198	0	35	theme	Osteogenic	101:110	arg1	Properties					112:121	Biocompatibility and Osteogenic Properties	80:121	Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels	80:187	Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels.
33430198	4	36	theme	moldable	1023:1030	arg1	properties					1032:1041	optimal composite mechanical and moldable properties	990:1041	optimal composite mechanical and moldable properties	990:1041	The addition of 12 wt% polylactide granules resulted in optimal composite mechanical and moldable properties, and increased the modulus of elasticity of the hydrogel-based material by approximately 100 times.
33430198	6	37	theme	polylactide	1411:1421	arg1	granules					1423:1430	highly porous polylactide granules	1397:1430	highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2)	1397:1484	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	8	38	theme	bone	1820:1823	arg1	tissue					1825:1830	bone tissue	1820:1830	bone tissue	1820:1830	Implantation of the material with 50 μg/mL BMP-2 was accompanied with excessive growth of bone tissue and material displacement beyond the defect.
33430198	7	39	theme	BMP-2	1652:1656	arg1	μg/mL					1665:1669	10 μg/mL	1662:1669	10 μg/mL	1662:1669	When implanted into a critical-size calvarial defect in rats, the optimal concentration of BMP-2 was 10 μg/mL: bone tissue areas filled the entire material's thickness.
33430198	7	39	theme	BMP-2	1652:1656	arg1	concentration					1635:1647	the optimal concentration	1623:1647	the optimal concentration of BMP-2	1623:1656	When implanted into a critical-size calvarial defect in rats, the optimal concentration of BMP-2 was 10 μg/mL: bone tissue areas filled the entire material's thickness.
33430198	8	40	theme	material	1750:1757	arg1	Implantation					1730:1741	Implantation	1730:1741	Implantation of the material with 50 μg/mL BMP-2	1730:1777	Implantation of the material with 50 μg/mL BMP-2 was accompanied with excessive growth of bone tissue and material displacement beyond the defect.
33430198	4	41	theme	optimal	990:996	arg1	properties					1032:1041	optimal composite mechanical and moldable properties	990:1041	optimal composite mechanical and moldable properties	990:1041	The addition of 12 wt% polylactide granules resulted in optimal composite mechanical and moldable properties, and increased the modulus of elasticity of the hydrogel-based material by approximately 100 times.
33430198	2	42	theme	purification	477:488	arg1	degree					467:472	degree	467:472	degree of purification	467:488	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	2	42	theme	purification	477:488	arg1	length					459:464	chain length	453:464	chain length	453:464	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	2	42	theme	purification	477:488	arg1	weight					505:510	molecular weight	495:510	molecular weight	495:510	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	4	43	theme	mechanical	1008:1017	arg1	properties					1032:1041	optimal composite mechanical and moldable properties	990:1041	optimal composite mechanical and moldable properties	990:1041	The addition of 12 wt% polylactide granules resulted in optimal composite mechanical and moldable properties, and increased the modulus of elasticity of the hydrogel-based material by approximately 100 times.
33430198	6	44	theme	DD	1388:1389	arg1	chitosan					1375:1382	reacetylated chitosan	1362:1382	reacetylated chitosan (39 DD%)	1362:1391	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	6	44	theme	DD	1388:1389	arg1	%					1390:1390	39 DD%	1385:1390	39 DD%	1385:1390	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	4	45	theme	elasticity	1073:1082	arg1	modulus					1062:1068	the modulus	1058:1068	the modulus of elasticity of the hydrogel-based material	1058:1113	The addition of 12 wt% polylactide granules resulted in optimal composite mechanical and moldable properties, and increased the modulus of elasticity of the hydrogel-based material by approximately 100 times.
33430198	8	46	theme	μg/mL	1767:1771	arg1	BMP-2					1773:1777	50 μg/mL BMP-2	1764:1777	50 μg/mL BMP-2	1764:1777	Implantation of the material with 50 μg/mL BMP-2 was accompanied with excessive growth of bone tissue and material displacement beyond the defect.
33430198	3	47	theme	chitosan/β-glycerophosphate	661:687	arg1	hydrogel					689:696	the chitosan/β-glycerophosphate hydrogel	657:696	the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD%	657:727	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	6	48	theme	bone	1456:1459	arg1	BMP-2					1449:1453	BMP-2	1449:1453	BMP-2 (bone morphogenetic protein-2)	1449:1484	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	6	48	theme	bone	1456:1459	arg1	protein-2					1475:1483	bone morphogenetic protein-2	1456:1483	bone morphogenetic protein-2	1456:1483	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	3	49	theme	multipotent	791:801	arg1	cells					811:815	multipotent stromal cells	791:815	multipotent stromal cells	791:815	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	3	49	theme	multipotent	791:801	arg1	MSCs					785:788	the MSCs	781:788	the MSCs (multipotent stromal cells) viability rate	781:831	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	3	50	theme	reduced	717:723	arg1	%					727:727	a reduced DD%	715:727	a reduced DD%	715:727	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	2	51	theme	such	429:432	arg1	characteristics					434:448	such characteristics	429:448	such characteristics as chain length, degree of purification, and molecular weight	429:510	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	8	52	theme	displacement	1845:1856	arg1	growth					1810:1815	excessive growth	1800:1815	excessive growth of bone tissue and material displacement beyond the defect	1800:1874	Implantation of the material with 50 μg/mL BMP-2 was accompanied with excessive growth of bone tissue and material displacement beyond the defect.
33430198	6	53	with	material	1348:1355	arg1	chitosan					1375:1382	reacetylated chitosan	1362:1382	reacetylated chitosan (39 DD%)	1362:1391	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	6	53	with	material	1348:1355	arg1	%					1390:1390	39 DD%	1385:1390	39 DD%	1385:1390	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	6	53	with	material	1348:1355	arg1	granules					1423:1430	highly porous polylactide granules	1397:1430	highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2)	1397:1484	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	1	54	theme	bone	321:324	arg1	materials					332:340	moldable bone graft materials	312:340	moldable bone graft materials that have osteoinductive and osteoconductive properties	312:396	Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties.
33430198	2	55	from	influence	416:424	arg1	material					526:533	a designed material	515:533	a designed material	515:533	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	3	56	from	infiltration	868:879	arg1	implantation					897:908	subcutaneous implantation	884:908	subcutaneous implantation	884:908	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	9	57	theme	Significant	1877:1887	arg1	properties					1924:1933	Significant osteoinductive and osteoconductive properties	1877:1933	Significant osteoinductive and osteoconductive properties of the material with 10 μg/mL of BMP-2	1877:1972	Significant osteoinductive and osteoconductive properties of the material with 10 μg/mL of BMP-2 were also shown in subcutaneous implantation.
33430198	9	58	theme	osteoconductive	1908:1922	arg1	properties					1924:1933	Significant osteoinductive and osteoconductive properties	1877:1933	Significant osteoinductive and osteoconductive properties of the material with 10 μg/mL of BMP-2	1877:1972	Significant osteoinductive and osteoconductive properties of the material with 10 μg/mL of BMP-2 were also shown in subcutaneous implantation.
33430198	6	59	theme	orthotopic	1522:1531	arg1	formation					1550:1558	orthotopic and ectopic bone formation	1522:1558	formation	1550:1558	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	2	60	theme	designed	517:524	arg1	material					526:533	a designed material	515:533	a designed material	515:533	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	3	61	theme	%	727:727	arg1	chitosan					703:710	chitosan	703:710	chitosan of a reduced DD%	703:727	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	4	62	theme	material	1106:1113	arg1	elasticity					1073:1082	elasticity	1073:1082	elasticity of the hydrogel-based material	1073:1113	The addition of 12 wt% polylactide granules resulted in optimal composite mechanical and moldable properties, and increased the modulus of elasticity of the hydrogel-based material by approximately 100 times.
33430198	8	63	with	Implantation	1730:1741	arg1	BMP-2					1773:1777	50 μg/mL BMP-2	1764:1777	50 μg/mL BMP-2	1764:1777	Implantation of the material with 50 μg/mL BMP-2 was accompanied with excessive growth of bone tissue and material displacement beyond the defect.
33430198	0	64	theme	BMP-2/PLA	126:134	arg1	Hydrogels					179:187	BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels	126:187	BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels	126:187	Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels.
33430198	2	65	theme	DD	612:613	arg1	deacetylation					597:609	deacetylation	597:609	deacetylation (DD%) of 19.5, 39, 49, 55, and 56	597:643	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	2	65	theme	DD	612:613	arg1	%					614:614	DD%	612:614	DD%	612:614	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	3	66	theme	low	743:745	arg1	degree					747:752	a low degree	741:752	a low degree of deacetylation	741:769	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	0	67	theme	Chitosan/β-Glycerophosphate	151:177	arg1	Hydrogels					179:187	BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels	126:187	BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels	126:187	Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels.
33430198	7	68	theme	tissue	1677:1682	arg1	areas					1684:1688	bone tissue areas	1672:1688	bone tissue areas	1672:1688	When implanted into a critical-size calvarial defect in rats, the optimal concentration of BMP-2 was 10 μg/mL: bone tissue areas filled the entire material's thickness.
33430198	1	69	theme	polylactide	269:279	arg1	granules					281:288	highly porous polylactide granules	255:288	highly porous polylactide granules	255:288	Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties.
33430198	2	70	theme	deacetylation	597:609	arg1	degrees					586:592	degrees	586:592	degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56	586:643	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	3	71	theme	MSCs	785:788	arg1	rate					828:831	the MSCs (multipotent stromal cells) viability rate	781:831	the MSCs (multipotent stromal cells) viability rate	781:831	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	7	72	theme	critical-size	1583:1595	arg1	defect					1607:1612	a critical-size calvarial defect	1581:1612	a critical-size calvarial defect in rats	1581:1620	When implanted into a critical-size calvarial defect in rats, the optimal concentration of BMP-2 was 10 μg/mL: bone tissue areas filled the entire material's thickness.
33430198	2	73	theme	19.5	620:623	arg1	deacetylation					597:609	deacetylation	597:609	deacetylation (DD%) of 19.5, 39, 49, 55, and 56	597:643	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	2	73	theme	19.5	620:623	arg1	%					614:614	DD%	612:614	DD%	612:614	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	9	74	theme	BMP-2	1968:1972	arg1	μg/mL					1959:1963	10 μg/mL	1956:1963	10 μg/mL of BMP-2	1956:1972	Significant osteoinductive and osteoconductive properties of the material with 10 μg/mL of BMP-2 were also shown in subcutaneous implantation.
33430198	5	75	theme	~10	1258:1260	arg1	%					1261:1261	%	1261:1261	%	1261:1261	Excessive filling of the material with PLA (polylactide) granules (more than 20%) led to material destruction at a ~10% strain.
33430198	0	76	theme	BMP-2	57:61	arg1	Deacetylation					27:39	Deacetylation	27:39	Deacetylation of Chitosan and BMP-2 Concentration	27:75	Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels.
33430198	6	77	theme	formation	1550:1558	arg1	models					1512:1517	models	1512:1517	models of orthotopic and ectopic bone formation	1512:1558	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	4	78	theme	%	955:955	arg1	granules					969:976	12 wt% polylactide granules	950:976	12 wt% polylactide granules	950:976	The addition of 12 wt% polylactide granules resulted in optimal composite mechanical and moldable properties, and increased the modulus of elasticity of the hydrogel-based material by approximately 100 times.
33430198	6	79	theme	material	1348:1355	arg1	properties					1306:1315	Osteoinductive and osteoconductive properties	1271:1315	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2)	1271:1484	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	6	80	theme	ectopic	1537:1543	arg1	formation					1550:1558	orthotopic and ectopic bone formation	1522:1558	formation	1550:1558	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	3	81	theme	subcutaneous	884:895	arg1	implantation					897:908	subcutaneous implantation	884:908	subcutaneous implantation	884:908	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	2	82	theme	one-stock	540:548	arg1	sample					559:564	the one-stock chitosan sample	536:564	the one-stock chitosan sample	536:564	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	5	83	theme	material	1232:1239	arg1	destruction					1241:1251	material destruction	1232:1251	material destruction at a ~10% strain	1232:1268	Excessive filling of the material with PLA (polylactide) granules (more than 20%) led to material destruction at a ~10% strain.
33430198	5	84	theme	Excessive	1143:1151	arg1	filling					1153:1159	Excessive filling	1143:1159	Excessive filling of the material with PLA (polylactide) granules (more than 20%)	1143:1223	Excessive filling of the material with PLA (polylactide) granules (more than 20%) led to material destruction at a ~10% strain.
33430198	7	85	from	defect	1607:1612	arg1	rats					1617:1620	rats	1617:1620	rats	1617:1620	When implanted into a critical-size calvarial defect in rats, the optimal concentration of BMP-2 was 10 μg/mL: bone tissue areas filled the entire material's thickness.
33430198	3	86	theme	viability	818:826	arg1	rate					828:831	the MSCs (multipotent stromal cells) viability rate	781:831	the MSCs (multipotent stromal cells) viability rate	781:831	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	6	87	theme	hydrogel-based	1333:1346	arg1	material					1348:1355	the chitosan hydrogel-based material	1320:1355	the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2)	1320:1484	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	7	88	theme	bone	1672:1675	arg1	areas					1684:1688	bone tissue areas	1672:1688	bone tissue areas	1672:1688	When implanted into a critical-size calvarial defect in rats, the optimal concentration of BMP-2 was 10 μg/mL: bone tissue areas filled the entire material's thickness.
33430198	8	89	theme	excessive	1800:1808	arg1	growth					1810:1815	excessive growth	1800:1815	excessive growth of bone tissue and material displacement beyond the defect	1800:1874	Implantation of the material with 50 μg/mL BMP-2 was accompanied with excessive growth of bone tissue and material displacement beyond the defect.
33430198	2	90	theme	chain	453:457	arg1	length					459:464	chain length	453:464	chain length	453:464	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	0	91	theme	Degree	17:22	arg1	Influence					0:8	Influence	0:8	Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels.	0:188	Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels.
33430198	5	92	theme	PLA	1182:1184	arg1	%					1222:1222	more than 20%	1210:1222	more than 20%	1210:1222	Excessive filling of the material with PLA (polylactide) granules (more than 20%) led to material destruction at a ~10% strain.
33430198	5	92	theme	PLA	1182:1184	arg1	granules					1200:1207	PLA (polylactide) granules	1182:1207	PLA (polylactide) granules (more than 20%)	1182:1223	Excessive filling of the material with PLA (polylactide) granules (more than 20%) led to material destruction at a ~10% strain.
33430198	2	93	theme	molecular	495:503	arg1	weight					505:510	molecular weight	495:510	molecular weight	495:510	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
33430198	0	94	theme	Deacetylation	27:39	arg1	Degree					17:22	the Degree	13:22	the Degree of Deacetylation of Chitosan and BMP-2 Concentration	13:75	Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels.
33430198	1	95	theme	osteoinductive	352:365	arg1	properties					387:396	osteoinductive and osteoconductive properties	352:396	osteoinductive and osteoconductive properties	352:396	Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties.
33430198	0	96	dep	Chitosan	44:51	arg1	Concentration					63:75	Concentration	63:75	Concentration	63:75	Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels.
33430198	4	97	theme	granules	969:976	arg1	addition					938:945	The addition	934:945	The addition of 12 wt% polylactide granules	934:976	The addition of 12 wt% polylactide granules resulted in optimal composite mechanical and moldable properties, and increased the modulus of elasticity of the hydrogel-based material by approximately 100 times.
33430198	9	98	with	properties	1924:1933	arg1	μg/mL					1959:1963	10 μg/mL	1956:1963	10 μg/mL of BMP-2	1956:1972	Significant osteoinductive and osteoconductive properties of the material with 10 μg/mL of BMP-2 were also shown in subcutaneous implantation.
33430198	6	99	theme	chitosan	1324:1331	arg1	material					1348:1355	the chitosan hydrogel-based material	1320:1355	the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2)	1320:1484	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	0	100	theme	Chitosan	44:51	arg1	Deacetylation					27:39	Deacetylation	27:39	Deacetylation of Chitosan and BMP-2 Concentration	27:75	Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels.
33430198	1	101	theme	osteoconductive	371:385	arg1	properties					387:396	osteoinductive and osteoconductive properties	352:396	osteoinductive and osteoconductive properties	352:396	Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties.
33430198	1	102	with	hydrogels	240:248	arg1	granules					281:288	highly porous polylactide granules	255:288	highly porous polylactide granules	255:288	Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties.
33430198	4	103	theme	composite	998:1006	arg1	properties					1032:1041	optimal composite mechanical and moldable properties	990:1041	optimal composite mechanical and moldable properties	990:1041	The addition of 12 wt% polylactide granules resulted in optimal composite mechanical and moldable properties, and increased the modulus of elasticity of the hydrogel-based material by approximately 100 times.
33430198	3	104	theme	hydrogel	689:696	arg1	study					648:652	A study	646:652	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD%	646:727	A study of the chitosan/β-glycerophosphate hydrogel with chitosan of a reduced DD% showed that a low degree of deacetylation increased the MSCs (multipotent stromal cells) viability rate in vitro and reduced the leukocyte infiltration in subcutaneous implantation to Wistar rats in vivo.
33430198	5	105	theme	material	1168:1175	arg1	filling					1153:1159	Excessive filling	1143:1159	Excessive filling of the material with PLA (polylactide) granules (more than 20%)	1143:1223	Excessive filling of the material with PLA (polylactide) granules (more than 20%) led to material destruction at a ~10% strain.
33430198	1	106	used	used	297:300	arg2	Compositions					190:201	Compositions	190:201	Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules	190:288	Compositions based on chitosan/β-glycerophosphate hydrogels with highly porous polylactide granules can be used to obtain moldable bone graft materials that have osteoinductive and osteoconductive properties.
33430198	6	107	theme	osteoconductive	1290:1304	arg1	properties					1306:1315	Osteoinductive and osteoconductive properties	1271:1315	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2)	1271:1484	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	6	108	theme	morphogenetic	1461:1473	arg1	BMP-2					1449:1453	BMP-2	1449:1453	BMP-2 (bone morphogenetic protein-2)	1449:1484	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	6	108	theme	morphogenetic	1461:1473	arg1	protein-2					1475:1483	bone morphogenetic protein-2	1456:1483	bone morphogenetic protein-2	1456:1483	Osteoinductive and osteoconductive properties of the chitosan hydrogel-based material with reacetylated chitosan (39 DD%) and highly porous polylactide granules impregnated with BMP-2 (bone morphogenetic protein-2) have been demonstrated in models of orthotopic and ectopic bone formation.
33430198	2	109	theme	characteristics	434:448	arg1	influence					416:424	the influence	412:424	the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material	412:533	To eliminate the influence of such characteristics as chain length, degree of purification, and molecular weight on a designed material, the one-stock chitosan sample was reacetylated to degrees of deacetylation (DD%) of 19.5, 39, 49, 55, and 56.
34110080	2	0	theme	stability	611:619	arg1	pDNA					575:578	pDNA	575:578	pDNA	575:578	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	0	theme	stability	611:619	arg1	cytotoxicity					545:556	cytotoxicity	545:556	cytotoxicity	545:556	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	0	theme	stability	611:619	arg1	DNA					570:572	plasmid DNA	562:572	plasmid DNA (pDNA)	562:579	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	0	theme	stability	611:619	arg1	effect					537:542	the anti-inflammatory effect	515:542	the anti-inflammatory effect	515:542	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	5	1	from	ratios	1174:1179	arg1	nanocomposites					1148:1161	AG/pDNA nanocomposites	1140:1161	AG/pDNA nanocomposites at the N/P ratios of 10 and 20	1140:1192	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	6	2	theme	potent	1529:1534	arg1	effect					1554:1559	its potent anti-inflammatory effect	1525:1559	its potent anti-inflammatory effect	1525:1559	These results indicate that AG is a potential candidate for DNA delivery system due to its potent anti-inflammatory effect and high transfection efficiency.
34110080	5	3	theme	superior	1212:1219	arg1	efficiencies					1234:1245	superior transfection efficiencies	1212:1245	superior transfection efficiencies in RAW 264.7 cells	1212:1264	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	3	theme	superior	1212:1219	arg1	interaction					1370:1380	the specific interaction	1357:1380	the specific interaction with pattern recognition receptors (Dectin-1 and TLR2)	1357:1435	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	3	theme	superior	1212:1219	arg1	result					1271:1276	a result	1269:1276	a result of their suitable particle size	1269:1308	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	2	4	theme	sizes	635:639	arg1	pDNA					575:578	pDNA	575:578	pDNA	575:578	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	4	theme	sizes	635:639	arg1	cytotoxicity					545:556	cytotoxicity	545:556	cytotoxicity	545:556	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	4	theme	sizes	635:639	arg1	DNA					570:572	plasmid DNA	562:572	plasmid DNA (pDNA)	562:579	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	4	theme	sizes	635:639	arg1	effect					537:542	the anti-inflammatory effect	515:542	the anti-inflammatory effect	515:542	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	1	5	theme	antioxidative	280:292	arg1	effects					294:300	antitumor, antimicrobial, anti-inflammatory and antioxidative effects	232:300	antitumor, antimicrobial, anti-inflammatory and antioxidative effects	232:300	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	2	6	dep	sizes	635:639	arg1	the					622:624	the	622:624	the	622:624	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	6	7	theme	DNA	1498:1500	arg1	system					1511:1516	DNA delivery system	1498:1516	DNA delivery system due to its potent anti-inflammatory effect and high transfection efficiency	1498:1592	These results indicate that AG is a potential candidate for DNA delivery system due to its potent anti-inflammatory effect and high transfection efficiency.
34110080	0	8	theme	activity	117:124	arg1	study					86:90	The in vitro study	73:90	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.	0:153	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.
34110080	4	9	dep	100	1135:1137	arg1	to					1132:1133	to	1132:1133	to	1132:1133	AG/pDNA nanocomposites prepared by electrostatic interaction possess an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100.
34110080	2	10	theme	efficiency	709:718	arg1	pDNA					575:578	pDNA	575:578	pDNA	575:578	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	10	theme	efficiency	709:718	arg1	cytotoxicity					545:556	cytotoxicity	545:556	cytotoxicity	545:556	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	10	theme	efficiency	709:718	arg1	DNA					570:572	plasmid DNA	562:572	plasmid DNA (pDNA)	562:579	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	10	theme	efficiency	709:718	arg1	effect					537:542	the anti-inflammatory effect	515:542	the anti-inflammatory effect	515:542	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	0	11	theme	transfection	130:141	arg1	efficiency					143:152	transfection efficiency	130:152	transfection efficiency	130:152	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.
34110080	2	12	theme	binding	581:587	arg1	capacity					589:596	binding capacity	581:596	binding capacity	581:596	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	5	13	from	efficiencies	1234:1245	arg1	cells					1260:1264	RAW 264.7 cells	1250:1264	RAW 264.7 cells	1250:1264	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	14	with	potential	1316:1324	arg1	Dectin-1					1418:1425	Dectin-1	1418:1425	Dectin-1	1418:1425	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	14	with	potential	1316:1324	arg1	receptors					1407:1415	pattern recognition receptors	1387:1415	pattern recognition receptors (Dectin-1 and TLR2)	1387:1435	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	14	with	potential	1316:1324	arg1	TLR2					1431:1434	TLR2	1431:1434	TLR2	1431:1434	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	6	15	theme	high	1565:1568	arg1	efficiency					1583:1592	high transfection efficiency	1565:1592	high transfection efficiency	1565:1592	These results indicate that AG is a potential candidate for DNA delivery system due to its potent anti-inflammatory effect and high transfection efficiency.
34110080	4	16	theme	particle	1010:1017	arg1	size					1019:1022	an appropriate particle size	995:1022	an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100	995:1137	AG/pDNA nanocomposites prepared by electrostatic interaction possess an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100.
34110080	2	17	theme	action	737:742	arg1	stability					611:619	serum stability	605:619	serum stability	605:619	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	17	theme	action	737:742	arg1	potentials					650:659	zeta potentials	645:659	zeta potentials	645:659	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	17	theme	action	737:742	arg1	efficiency					709:718	the transfection efficiency	692:718	the transfection efficiency	692:718	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	17	theme	action	737:742	arg1	sizes					635:639	particle sizes	626:639	particle sizes	626:639	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	17	theme	action	737:742	arg1	AG					601:602	AG	601:602	AG	601:602	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	17	theme	action	737:742	arg1	mechanism					724:732	mechanism	724:732	mechanism	724:732	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	5	18	theme	suitable	1287:1294	arg1	size					1305:1308	their suitable particle size	1281:1308	their suitable particle size	1281:1308	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	19	with	interaction	1370:1380	arg1	Dectin-1					1418:1425	Dectin-1	1418:1425	Dectin-1	1418:1425	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	19	with	interaction	1370:1380	arg1	receptors					1407:1415	pattern recognition receptors	1387:1415	pattern recognition receptors (Dectin-1 and TLR2)	1387:1435	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	19	with	interaction	1370:1380	arg1	TLR2					1431:1434	TLR2	1431:1434	TLR2	1431:1434	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	1	20	theme	neutral	332:338	arg1	solution					348:355	neutral aqueous solution	332:355	neutral aqueous solution	332:355	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	3	21	theme	independent	892:902	arg1	effect					885:890	potent anti-inflammatory effect independent	860:902	potent anti-inflammatory effect independent	860:902	AG shows no obvious cytotoxicity within the range of working concentration (1-64 μg/ml) and it exerts potent anti-inflammatory effect independent on Dectin-1 and TLR2.
34110080	4	22	dep	27.16 mV	1096:1103	arg1	to					1093:1094	to	1093:1094	to	1093:1094	AG/pDNA nanocomposites prepared by electrostatic interaction possess an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100.
34110080	3	23	theme	anti-inflammatory	867:883	arg1	effect					885:890	potent anti-inflammatory effect independent	860:902	potent anti-inflammatory effect independent	860:902	AG shows no obvious cytotoxicity within the range of working concentration (1-64 μg/ml) and it exerts potent anti-inflammatory effect independent on Dectin-1 and TLR2.
34110080	3	24	theme	concentration	819:831	arg1	range					802:806	the range	798:806	the range of working concentration (1-64 μg/ml)	798:844	AG shows no obvious cytotoxicity within the range of working concentration (1-64 μg/ml) and it exerts potent anti-inflammatory effect independent on Dectin-1 and TLR2.
34110080	0	25	theme	in	77:78	arg1	study					86:90	The in vitro study	73:90	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.	0:153	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.
34110080	5	26	with	result	1271:1276	arg1	Dectin-1					1418:1425	Dectin-1	1418:1425	Dectin-1	1418:1425	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	26	with	result	1271:1276	arg1	receptors					1407:1415	pattern recognition receptors	1387:1415	pattern recognition receptors (Dectin-1 and TLR2)	1387:1435	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	26	with	result	1271:1276	arg1	TLR2					1431:1434	TLR2	1431:1434	TLR2	1431:1434	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	0	27	dep	in	77:78	arg1	vitro					80:84	vitro	80:84	vitro	80:84	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.
34110080	4	28	theme	zeta	1058:1061	arg1	potentials					1063:1072	118.4 nm and zeta potentials	1045:1072	potentials	1063:1072	AG/pDNA nanocomposites prepared by electrostatic interaction possess an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100.
34110080	2	29	theme	anti-inflammatory	519:535	arg1	effect					537:542	the anti-inflammatory effect	515:542	the anti-inflammatory effect	515:542	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	1	30	from	application	395:405	arg1	fields					434:439	biological and medicine fields	410:439	biological and medicine fields	410:439	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	5	31	theme	10	1184:1185	arg1	ratios					1174:1179	the N/P ratios	1166:1179	the N/P ratios of 10 and 20	1166:1192	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	2	32	theme	water-soluble	452:464	arg1	AG					491:492	AG	491:492	AG	491:492	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	32	theme	water-soluble	452:464	arg1	β-1,3-D-glucan					475:488	a water-soluble aminated β-1,3-D-glucan	450:488	a water-soluble aminated β-1,3-D-glucan (AG)	450:493	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	33	theme	AG/pDNA	664:670	arg1	nanocomposites					672:685	AG/pDNA nanocomposites	664:685	AG/pDNA nanocomposites	664:685	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	5	34	theme	size	1305:1308	arg1	efficiencies					1234:1245	superior transfection efficiencies	1212:1245	superior transfection efficiencies in RAW 264.7 cells	1212:1264	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	34	theme	size	1305:1308	arg1	potential					1316:1324	zeta potential	1311:1324	zeta potential	1311:1324	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	34	theme	size	1305:1308	arg1	interaction					1370:1380	the specific interaction	1357:1380	the specific interaction with pattern recognition receptors (Dectin-1 and TLR2)	1357:1435	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	34	theme	size	1305:1308	arg1	result					1271:1276	a result	1269:1276	a result of their suitable particle size	1269:1308	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	34	theme	size	1305:1308	arg1	effect					1345:1350	anti-inflammatory effect	1327:1350	anti-inflammatory effect	1327:1350	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	35	theme	20	1191:1192	arg1	ratios					1174:1179	the N/P ratios	1166:1179	the N/P ratios of 10 and 20	1166:1192	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	2	36	dep	effect	537:542	arg1	capacity					589:596	binding capacity	581:596	binding capacity	581:596	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	5	37	theme	zeta	1311:1314	arg1	potential					1316:1324	zeta potential	1311:1324	zeta potential	1311:1324	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	0	38	theme	soluble	23:29	arg1	β-1,3-D-glucan					40:53	a water soluble aminated β-1,3-D-glucan	15:53	a water soluble aminated β-1,3-D-glucan	15:53	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.
34110080	4	39	contain	possess	987:993	arg1	nanocomposites					934:947	AG/pDNA nanocomposites	926:947	AG/pDNA nanocomposites prepared by electrostatic interaction	926:985	AG/pDNA nanocomposites prepared by electrostatic interaction possess an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100.
34110080	4	39	contain	possess	987:993	arg2	size					1019:1022	an appropriate particle size	995:1022	an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100	995:1137	AG/pDNA nanocomposites prepared by electrostatic interaction possess an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100.
34110080	4	40	theme	118.4 nm	1045:1052	arg1	potentials					1063:1072	118.4 nm and zeta potentials	1045:1072	potentials	1063:1072	AG/pDNA nanocomposites prepared by electrostatic interaction possess an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100.
34110080	0	41	theme	gene	59:62	arg1	carrier					64:70	gene carrier	59:70	gene carrier	59:70	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.
34110080	0	42	theme	β-1,3-D-glucan	40:53	arg1	Preparation					0:10	Preparation	0:10	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.	0:153	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.
34110080	5	43	theme	recognition	1395:1405	arg1	Dectin-1					1418:1425	Dectin-1	1418:1425	Dectin-1	1418:1425	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	43	theme	recognition	1395:1405	arg1	receptors					1407:1415	pattern recognition receptors	1387:1415	pattern recognition receptors (Dectin-1 and TLR2)	1387:1435	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	43	theme	recognition	1395:1405	arg1	TLR2					1431:1434	TLR2	1431:1434	TLR2	1431:1434	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	6	44	theme	potential	1474:1482	arg1	AG					1466:1467	AG	1466:1467	AG	1466:1467	These results indicate that AG is a potential candidate for DNA delivery system due to its potent anti-inflammatory effect and high transfection efficiency.
34110080	6	44	theme	potential	1474:1482	arg1	candidate					1484:1492	a potential candidate	1472:1492	a potential candidate for DNA delivery system due to its potent anti-inflammatory effect and high transfection efficiency	1472:1592	These results indicate that AG is a potential candidate for DNA delivery system due to its potent anti-inflammatory effect and high transfection efficiency.
34110080	1	45	theme	bioactivities	208:220	arg1	series					198:203	a series	196:203	a series of bioactivities	196:220	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	1	46	contain	have	191:194	arg2	series					198:203	a series	196:203	a series of bioactivities	196:220	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	1	46	contain	have	191:194	arg1	β-1,3-D-glucan					155:168	β-1,3-D-glucan	155:168	β-1,3-D-glucan	155:168	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	1	47	theme	antitumor	232:240	arg1	effects					294:300	antitumor, antimicrobial, anti-inflammatory and antioxidative effects	232:300	antitumor, antimicrobial, anti-inflammatory and antioxidative effects	232:300	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	0	48	dep	Preparation	0:10	arg1	study					86:90	The in vitro study	73:90	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.	0:153	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.
34110080	1	49	from	insolubility	316:327	arg1	solution					348:355	neutral aqueous solution	332:355	neutral aqueous solution	332:355	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	5	50	theme	specific	1361:1368	arg1	efficiencies					1234:1245	superior transfection efficiencies	1212:1245	superior transfection efficiencies in RAW 264.7 cells	1212:1264	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	50	theme	specific	1361:1368	arg1	interaction					1370:1380	the specific interaction	1357:1380	the specific interaction with pattern recognition receptors (Dectin-1 and TLR2)	1357:1435	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	1	51	theme	antimicrobial	243:255	arg1	effects					294:300	antitumor, antimicrobial, anti-inflammatory and antioxidative effects	232:300	antitumor, antimicrobial, anti-inflammatory and antioxidative effects	232:300	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	5	52	theme	AG/pDNA	1140:1146	arg1	nanocomposites					1148:1161	AG/pDNA nanocomposites	1140:1161	AG/pDNA nanocomposites at the N/P ratios of 10 and 20	1140:1192	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	2	53	theme	serum	605:609	arg1	stability					611:619	serum stability	605:619	serum stability	605:619	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	1	54	theme	anti-inflammatory	258:274	arg1	effects					294:300	antitumor, antimicrobial, anti-inflammatory and antioxidative effects	232:300	antitumor, antimicrobial, anti-inflammatory and antioxidative effects	232:300	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	2	55	theme	AG	601:602	arg1	pDNA					575:578	pDNA	575:578	pDNA	575:578	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	55	theme	AG	601:602	arg1	cytotoxicity					545:556	cytotoxicity	545:556	cytotoxicity	545:556	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	55	theme	AG	601:602	arg1	DNA					570:572	plasmid DNA	562:572	plasmid DNA (pDNA)	562:579	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	55	theme	AG	601:602	arg1	effect					537:542	the anti-inflammatory effect	515:542	the anti-inflammatory effect	515:542	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	56	theme	particle	626:633	arg1	sizes					635:639	particle sizes	626:639	particle sizes	626:639	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	0	57	theme	anti-inflammatory	99:115	arg1	activity					117:124	the anti-inflammatory activity	95:124	the anti-inflammatory activity	95:124	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.
34110080	6	58	theme	delivery	1502:1509	arg1	system					1511:1516	DNA delivery system	1498:1516	DNA delivery system due to its potent anti-inflammatory effect and high transfection efficiency	1498:1592	These results indicate that AG is a potential candidate for DNA delivery system due to its potent anti-inflammatory effect and high transfection efficiency.
34110080	4	59	from	100	1135:1137	arg1	ratios					1118:1123	the N/P ratios	1110:1123	the N/P ratios from 5 to 100	1110:1137	AG/pDNA nanocomposites prepared by electrostatic interaction possess an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100.
34110080	4	60	theme	AG/pDNA	926:932	arg1	nanocomposites					934:947	AG/pDNA nanocomposites	926:947	AG/pDNA nanocomposites prepared by electrostatic interaction	926:985	AG/pDNA nanocomposites prepared by electrostatic interaction possess an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100.
34110080	5	61	dep	receptors	1407:1415	arg1	Dectin-1					1418:1425	Dectin-1	1418:1425	Dectin-1	1418:1425	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	61	dep	receptors	1407:1415	arg1	receptors					1407:1415	pattern recognition receptors	1387:1415	pattern recognition receptors (Dectin-1 and TLR2)	1387:1435	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	61	dep	receptors	1407:1415	arg1	TLR2					1431:1434	TLR2	1431:1434	TLR2	1431:1434	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	2	62	theme	plasmid	562:568	arg1	pDNA					575:578	pDNA	575:578	pDNA	575:578	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	62	theme	plasmid	562:568	arg1	DNA					570:572	plasmid DNA	562:572	plasmid DNA (pDNA)	562:579	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	0	63	theme	efficiency	143:152	arg1	study					86:90	The in vitro study	73:90	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.	0:153	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.
34110080	1	64	theme	medicine	425:432	arg1	fields					434:439	biological and medicine fields	410:439	biological and medicine fields	410:439	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	2	65	theme	transfection	696:707	arg1	efficiency					709:718	the transfection efficiency	692:718	the transfection efficiency	692:718	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	3	66	theme	obvious	770:776	arg1	cytotoxicity					778:789	no obvious cytotoxicity	767:789	no obvious cytotoxicity	767:789	AG shows no obvious cytotoxicity within the range of working concentration (1-64 μg/ml) and it exerts potent anti-inflammatory effect independent on Dectin-1 and TLR2.
34110080	5	67	with	effect	1345:1350	arg1	Dectin-1					1418:1425	Dectin-1	1418:1425	Dectin-1	1418:1425	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	67	with	effect	1345:1350	arg1	receptors					1407:1415	pattern recognition receptors	1387:1415	pattern recognition receptors (Dectin-1 and TLR2)	1387:1435	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	67	with	effect	1345:1350	arg1	TLR2					1431:1434	TLR2	1431:1434	TLR2	1431:1434	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	6	68	theme	transfection	1570:1581	arg1	efficiency					1583:1592	high transfection efficiency	1565:1592	high transfection efficiency	1565:1592	These results indicate that AG is a potential candidate for DNA delivery system due to its potent anti-inflammatory effect and high transfection efficiency.
34110080	3	69	theme	potent	860:865	arg1	effect					885:890	potent anti-inflammatory effect independent	860:902	potent anti-inflammatory effect independent	860:902	AG shows no obvious cytotoxicity within the range of working concentration (1-64 μg/ml) and it exerts potent anti-inflammatory effect independent on Dectin-1 and TLR2.
34110080	3	70	theme	working	811:817	arg1	1-64 μg/ml					834:843	1-64 μg/ml	834:843	1-64 μg/ml	834:843	AG shows no obvious cytotoxicity within the range of working concentration (1-64 μg/ml) and it exerts potent anti-inflammatory effect independent on Dectin-1 and TLR2.
34110080	3	70	theme	working	811:817	arg1	concentration					819:831	working concentration	811:831	working concentration (1-64 μg/ml)	811:844	AG shows no obvious cytotoxicity within the range of working concentration (1-64 μg/ml) and it exerts potent anti-inflammatory effect independent on Dectin-1 and TLR2.
34110080	4	71	theme	appropriate	998:1008	arg1	size					1019:1022	an appropriate particle size	995:1022	an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100	995:1137	AG/pDNA nanocomposites prepared by electrostatic interaction possess an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100.
34110080	5	72	theme	transfection	1221:1232	arg1	efficiencies					1234:1245	superior transfection efficiencies	1212:1245	superior transfection efficiencies in RAW 264.7 cells	1212:1264	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	72	theme	transfection	1221:1232	arg1	interaction					1370:1380	the specific interaction	1357:1380	the specific interaction with pattern recognition receptors (Dectin-1 and TLR2)	1357:1435	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	72	theme	transfection	1221:1232	arg1	result					1271:1276	a result	1269:1276	a result of their suitable particle size	1269:1308	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	1	73	theme	aqueous	340:346	arg1	solution					348:355	neutral aqueous solution	332:355	neutral aqueous solution	332:355	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	6	74	theme	anti-inflammatory	1536:1552	arg1	effect					1554:1559	its potent anti-inflammatory effect	1525:1559	its potent anti-inflammatory effect	1525:1559	These results indicate that AG is a potential candidate for DNA delivery system due to its potent anti-inflammatory effect and high transfection efficiency.
34110080	4	75	theme	electrostatic	961:973	arg1	interaction					975:985	electrostatic interaction	961:985	electrostatic interaction	961:985	AG/pDNA nanocomposites prepared by electrostatic interaction possess an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100.
34110080	2	76	theme	zeta	645:648	arg1	potentials					650:659	zeta potentials	645:659	zeta potentials	645:659	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	5	77	theme	anti-inflammatory	1327:1343	arg1	effect					1345:1350	anti-inflammatory effect	1327:1350	anti-inflammatory effect	1327:1350	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	2	78	theme	aminated	466:473	arg1	AG					491:492	AG	491:492	AG	491:492	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	78	theme	aminated	466:473	arg1	β-1,3-D-glucan					475:488	a water-soluble aminated β-1,3-D-glucan	450:488	a water-soluble aminated β-1,3-D-glucan (AG)	450:493	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	79	theme	nanocomposites	672:685	arg1	stability					611:619	serum stability	605:619	serum stability	605:619	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	79	theme	nanocomposites	672:685	arg1	potentials					650:659	zeta potentials	645:659	zeta potentials	645:659	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	79	theme	nanocomposites	672:685	arg1	efficiency					709:718	the transfection efficiency	692:718	the transfection efficiency	692:718	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	79	theme	nanocomposites	672:685	arg1	sizes					635:639	particle sizes	626:639	particle sizes	626:639	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	79	theme	nanocomposites	672:685	arg1	AG					601:602	AG	601:602	AG	601:602	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	2	79	theme	nanocomposites	672:685	arg1	mechanism					724:732	mechanism	724:732	mechanism	724:732	Herein, a water-soluble aminated β-1,3-D-glucan (AG) was synthesized and the anti-inflammatory effect, cytotoxicity and plasmid DNA (pDNA) binding capacity of AG, serum stability, the particle sizes and zeta potentials of AG/pDNA nanocomposites, and the transfection efficiency and mechanism of action were studied.
34110080	5	80	theme	particle	1296:1303	arg1	size					1305:1308	their suitable particle size	1281:1308	their suitable particle size	1281:1308	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	1	81	theme	biological	410:419	arg1	fields					434:439	biological and medicine fields	410:439	biological and medicine fields	410:439	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	0	82	theme	aminated	31:38	arg1	β-1,3-D-glucan					40:53	a water soluble aminated β-1,3-D-glucan	15:53	a water soluble aminated β-1,3-D-glucan	15:53	Preparation of a water soluble aminated β-1,3-D-glucan for gene carrier: The in vitro study of the anti-inflammatory activity and transfection efficiency.
34110080	5	83	theme	N/P	1170:1172	arg1	ratios					1174:1179	the N/P ratios	1166:1179	the N/P ratios of 10 and 20	1166:1192	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	1	84	theme	potential	385:393	arg1	application					395:405	the potential application	381:405	the potential application in biological and medicine fields	381:439	β-1,3-D-glucan has been reported to have a series of bioactivities including antitumor, antimicrobial, anti-inflammatory and antioxidative effects; however, its insolubility in neutral aqueous solution significantly restricts the potential application in biological and medicine fields.
34110080	5	85	theme	pattern	1387:1393	arg1	Dectin-1					1418:1425	Dectin-1	1418:1425	Dectin-1	1418:1425	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	85	theme	pattern	1387:1393	arg1	receptors					1407:1415	pattern recognition receptors	1387:1415	pattern recognition receptors (Dectin-1 and TLR2)	1387:1435	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	5	85	theme	pattern	1387:1393	arg1	TLR2					1431:1434	TLR2	1431:1434	TLR2	1431:1434	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
34110080	4	86	theme	N/P	1114:1116	arg1	ratios					1118:1123	the N/P ratios	1110:1123	the N/P ratios from 5 to 100	1110:1137	AG/pDNA nanocomposites prepared by electrostatic interaction possess an appropriate particle size ranged from 192.8 to 118.4 nm and zeta potentials ranged from 20.880 to 27.16 mV with the N/P ratios from 5 to 100.
34110080	5	87	theme	RAW	1250:1252	arg1	cells					1260:1264	RAW 264.7 cells	1250:1264	RAW 264.7 cells	1250:1264	AG/pDNA nanocomposites at the N/P ratios of 10 and 20 were able to show superior transfection efficiencies in RAW 264.7 cells as a result of their suitable particle size, zeta potential, anti-inflammatory effect, and the specific interaction with pattern recognition receptors (Dectin-1 and TLR2).
32676863	0	0	theme	Herbal	86:91	arg1	Particles					93:101	Co-Processed Herbal Particles	73:101	Co-Processed Herbal Particles	73:101	The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles Prepared by Fluid Bed Coating.
32676863	7	1	theme	mechanism	1268:1276	arg1	analysis					1278:1285	The mechanism analysis	1264:1285	The mechanism analysis	1264:1285	The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs.
32676863	6	2	with	ones	1157:1160	arg1	X-H					1170:1172	CP X-H	1167:1172	CP X-H	1167:1172	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	6	3	theme	longer	1236:1241	arg1	time					1258:1261	longer disintegration time	1236:1261	longer disintegration time	1236:1261	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	0	4	theme	Co-Processed	73:84	arg1	Particles					93:101	Co-Processed Herbal Particles	73:101	Co-Processed Herbal Particles	73:101	The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles Prepared by Fluid Bed Coating.
32676863	6	5	dep	X-H	866:868	arg1	i					860:860	i	860:860	i	860:860	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	8	6	theme	CPs	1594:1596	arg1	development					1561:1571	the development	1557:1571	the development of herbal core-shell CPs for DC	1557:1603	These findings are beneficial to the development of herbal core-shell CPs for DC.
32676863	6	7	theme	CP	863:864	arg1	X-H					866:868	(i) CP X-H	859:868	(i) CP X-H	859:868	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	7	8	from	differences	1307:1317	arg1	properties					1331:1340	physical properties	1322:1340	physical properties	1322:1340	The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs.
32676863	3	9	theme	CP	585:586	arg1	X-P					588:590	CP X-P	585:590	CP X-P	585:590	In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X).
32676863	3	9	theme	CP	585:586	arg1	PVP					580:582	PVP	580:582	PVP (CP X-P)	580:591	In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X).
32676863	8	10	theme	core-shell	1583:1592	arg1	CPs					1594:1596	herbal core-shell CPs	1576:1596	herbal core-shell CPs for DC	1576:1603	These findings are beneficial to the development of herbal core-shell CPs for DC.
32676863	2	11	theme	HPMC	467:470	arg1	effects					456:462	the different effects	442:462	the different effects of HPMC and PVP on the properties of herbal CPs	442:510	Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs.
32676863	5	12	from	differences	702:712	arg1	properties					717:726	properties	717:726	properties	717:726	The differences in properties between CP X-H and CP X-P were explored, and their mechanism analysis was also performed profoundly.
32676863	7	13	theme	particles	1475:1483	arg1	structure					1439:1447	structure	1439:1447	structure	1439:1447	The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs.
32676863	0	14	theme	Fluid	115:119	arg1	Coating					125:131	Fluid Bed Coating	115:131	Fluid Bed Coating	115:131	The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles Prepared by Fluid Bed Coating.
32676863	6	15	theme	CP	1095:1096	arg1	X-P					1098:1100	CP X-P	1095:1100	CP X-P	1095:1100	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	4	16	theme	physical	642:649	arg1	properties					651:660	Their physical properties	636:660	Their physical properties	636:660	Their physical properties were characterized comprehensively.
32676863	6	17	dep	compared	1109:1116	arg1	iii					1104:1106	iii	1104:1106	iii	1104:1106	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	6	18	theme	particle	1006:1013	arg1	distribution					1020:1031	more uniform particle size distribution	993:1031	more uniform particle size distribution	993:1031	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	5	19	theme	CP	747:748	arg1	X-P					750:752	CP X-P	747:752	CP X-P	747:752	The differences in properties between CP X-H and CP X-P were explored, and their mechanism analysis was also performed profoundly.
32676863	0	20	theme	Fundamental	4:14	arg1	Differences					40:50	The Fundamental and Functional Property Differences	0:50	The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles	0:101	The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles Prepared by Fluid Bed Coating.
32676863	6	21	theme	CP	1167:1168	arg1	X-H					1170:1172	CP X-H	1167:1172	CP X-H	1167:1172	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	6	22	theme	similar	1184:1190	arg1	%					1210:1210	%	1210:1210	%	1210:1210	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	6	22	theme	similar	1184:1190	arg1	variation					1199:1207	similar weight variation	1184:1207	similar weight variation (%)	1184:1211	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	6	23	theme	uniform	998:1004	arg1	distribution					1020:1031	more uniform particle size distribution	993:1031	more uniform particle size distribution	993:1031	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	6	24	theme	lower	1214:1218	arg1	friability					1220:1229	lower friability	1214:1229	lower friability	1214:1229	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	7	25	from	differences	1424:1434	arg1	properties					1505:1514	fundamental properties	1493:1514	fundamental properties of CPs	1493:1521	The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs.
32676863	7	25	from	differences	1424:1434	arg1	structure					1439:1447	structure	1439:1447	structure	1439:1447	The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs.
32676863	2	26	theme	Hydroxypropyl	281:293	arg1	materials					383:391	the shell materials	373:391	the shell materials	373:391	Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs.
32676863	2	26	theme	Hydroxypropyl	281:293	arg1	HPMC					312:315	HPMC	312:315	HPMC	312:315	Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs.
32676863	2	26	theme	Hydroxypropyl	281:293	arg1	polyvinylpyrrolidone					322:341	polyvinylpyrrolidone	322:341	polyvinylpyrrolidone (PVP)	322:347	Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs.
32676863	2	26	theme	Hydroxypropyl	281:293	arg1	methylcellulose					295:309	Hydroxypropyl methylcellulose	281:309	Hydroxypropyl methylcellulose (HPMC)	281:316	Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs.
32676863	3	27	contain	containing	569:578	arg2	PVP					580:582	PVP	580:582	PVP (CP X-P)	580:591	In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X).
32676863	3	27	contain	containing	569:578	arg1	CPs					565:567	CPs	565:567	CPs containing PVP (CP X-P)	565:591	In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X).
32676863	3	27	contain	containing	569:578	arg2	X-P					588:590	CP X-P	585:590	CP X-P	585:590	In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X).
32676863	0	28	theme	Functional	20:29	arg1	Differences					40:50	The Fundamental and Functional Property Differences	0:50	The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles	0:101	The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles Prepared by Fluid Bed Coating.
32676863	1	29	theme	herbal	254:259	arg1	tablets					261:267	herbal tablets	254:267	herbal tablets	254:267	Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited.
32676863	6	30	theme	CP	1149:1150	arg1	X-P					1152:1154	CP X-P	1149:1154	CP X-P	1149:1154	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	6	31	dep	X-H	920:922	arg1	ii					913:914	ii	913:914	ii	913:914	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	7	32	theme	surface	1453:1459	arg1	morphology					1461:1470	surface morphology	1453:1470	surface morphology	1453:1470	The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs.
32676863	1	33	theme	preferred	184:192	arg1	choice					194:199	the most preferred choice	175:199	the most preferred choice for direct compaction (DC)	175:226	Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited.
32676863	1	33	theme	preferred	184:192	arg1	particles					155:163	Core-shell composite particles	134:163	Core-shell composite particles (CPs)	134:169	Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited.
32676863	3	34	theme	herbal	616:621	arg1	X					632:632	X	632:632	X	632:632	In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X).
32676863	3	34	theme	herbal	616:621	arg1	powders					623:629	herbal powders	616:629	herbal powders (X)	616:633	In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X).
32676863	0	35	theme	Bed	121:123	arg1	Coating					125:131	Fluid Bed Coating	115:131	Fluid Bed Coating	115:131	The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles Prepared by Fluid Bed Coating.
32676863	7	36	theme	physical	1322:1329	arg1	properties					1331:1340	physical properties	1322:1340	physical properties	1322:1340	The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs.
32676863	1	37	theme	composite	145:153	arg1	choice					194:199	the most preferred choice	175:199	the most preferred choice for direct compaction (DC)	175:226	Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited.
32676863	1	37	theme	composite	145:153	arg1	particles					155:163	Core-shell composite particles	134:163	Core-shell composite particles (CPs)	134:169	Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited.
32676863	1	37	theme	composite	145:153	arg1	CPs					166:168	CPs	166:168	CPs	166:168	Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited.
32676863	5	38	theme	CP	736:737	arg1	X-H					739:741	CP X-H	736:741	CP X-H	736:741	The differences in properties between CP X-H and CP X-P were explored, and their mechanism analysis was also performed profoundly.
32676863	0	39	dep	HPMC	60:63	arg1	Particles					93:101	Co-Processed Herbal Particles	73:101	Co-Processed Herbal Particles	73:101	The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles Prepared by Fluid Bed Coating.
32676863	7	40	theme	CPs	1519:1521	arg1	properties					1505:1514	fundamental properties	1493:1514	fundamental properties of CPs	1493:1521	The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs.
32676863	2	41	theme	shell	377:381	arg1	materials					383:391	the shell materials	373:391	the shell materials	373:391	Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs.
32676863	2	41	theme	shell	377:381	arg1	polyvinylpyrrolidone					322:341	polyvinylpyrrolidone	322:341	polyvinylpyrrolidone (PVP)	322:347	Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs.
32676863	2	41	theme	shell	377:381	arg1	methylcellulose					295:309	Hydroxypropyl methylcellulose	281:309	Hydroxypropyl methylcellulose (HPMC)	281:316	Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs.
32676863	0	42	theme	Property	31:38	arg1	Differences					40:50	The Fundamental and Functional Property Differences	0:50	The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles	0:101	The Fundamental and Functional Property Differences Between HPMC and PVP Co-Processed Herbal Particles Prepared by Fluid Bed Coating.
32676863	2	43	theme	PVP	476:478	arg1	effects					456:462	the different effects	442:462	the different effects of HPMC and PVP on the properties of herbal CPs	442:510	Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs.
32676863	1	44	theme	direct	205:210	arg1	DC					224:225	DC	224:225	DC	224:225	Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited.
32676863	1	44	theme	direct	205:210	arg1	compaction					212:221	direct compaction	205:221	direct compaction (DC)	205:226	Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited.
32676863	3	45	theme	CP	553:554	arg1	X-H					556:558	CP X-H	553:558	CP X-H	553:558	In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X).
32676863	3	45	theme	CP	553:554	arg1	HPMC					547:550	HPMC	547:550	HPMC (CP X-H)	547:559	In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X).
32676863	6	46	theme	tap	1058:1060	arg1	density					1062:1068	tap density	1058:1068	tap density	1058:1068	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	5	47	theme	mechanism	779:787	arg1	analysis					789:796	their mechanism analysis	773:796	their mechanism analysis	773:796	The differences in properties between CP X-H and CP X-P were explored, and their mechanism analysis was also performed profoundly.
32676863	6	48	theme	weight	1192:1197	arg1	%					1210:1210	%	1210:1210	%	1210:1210	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	6	48	theme	weight	1192:1197	arg1	variation					1199:1207	similar weight variation	1184:1207	similar weight variation (%)	1184:1211	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	7	49	theme	fundamental	1386:1396	arg1	factors					1398:1404	the important and fundamental factors	1368:1404	the important and fundamental factors	1368:1404	The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs.
32676863	7	49	theme	fundamental	1386:1396	arg1	differences					1307:1317	the differences	1303:1317	the differences in physical properties between HPMC and PVP	1303:1361	The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs.
32676863	2	50	theme	CPs	508:510	arg1	properties					487:496	the properties	483:496	the properties of herbal CPs	483:510	Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs.
32676863	6	51	theme	particle	974:981	arg1	size					983:986	larger particle size	967:986	larger particle size	967:986	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	2	52	theme	herbal	501:506	arg1	CPs					508:510	herbal CPs	501:510	herbal CPs	501:510	Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs.
32676863	2	53	from	effects	456:462	arg1	properties					487:496	the properties	483:496	the properties of herbal CPs	483:510	Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs.
32676863	6	54	theme	larger	967:972	arg1	size					983:986	larger particle size	967:986	larger particle size	967:986	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	7	55	theme	important	1372:1380	arg1	factors					1398:1404	the important and fundamental factors	1368:1404	the important and fundamental factors	1368:1404	The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs.
32676863	7	55	theme	important	1372:1380	arg1	differences					1307:1317	the differences	1303:1317	the differences in physical properties between HPMC and PVP	1303:1361	The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs.
32676863	6	56	theme	bulk	1044:1047	arg1	density					1049:1055	lower bulk density	1038:1055	lower bulk density	1038:1055	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	6	57	theme	size	1015:1018	arg1	distribution					1020:1031	more uniform particle size distribution	993:1031	more uniform particle size distribution	993:1031	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	1	58	theme	Core-shell	134:143	arg1	choice					194:199	the most preferred choice	175:199	the most preferred choice for direct compaction (DC)	175:226	Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited.
32676863	1	58	theme	Core-shell	134:143	arg1	particles					155:163	Core-shell composite particles	134:163	Core-shell composite particles (CPs)	134:169	Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited.
32676863	1	58	theme	Core-shell	134:143	arg1	CPs					166:168	CPs	166:168	CPs	166:168	Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited.
32676863	2	59	theme	different	446:454	arg1	effects					456:462	the different effects	442:462	the different effects of HPMC and PVP on the properties of herbal CPs	442:510	Hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) are usually employed as the shell materials, but there are few, if any, researches exploring the different effects of HPMC and PVP on the properties of herbal CPs.
32676863	6	60	theme	similar	891:897	arg1	flowability					899:909	similar flowability	891:909	similar flowability	891:909	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	6	61	theme	lower	1038:1042	arg1	density					1049:1055	lower bulk density	1038:1055	lower bulk density	1038:1055	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	7	62	theme	fundamental	1493:1503	arg1	properties					1505:1514	fundamental properties	1493:1514	fundamental properties of CPs	1493:1521	The mechanism analysis manifested that the differences in physical properties between HPMC and PVP were the important and fundamental factors, which led to the differences in structure and surface morphology of particles, and in fundamental properties of CPs.
32676863	1	63	from	application	239:249	arg1	tablets					261:267	herbal tablets	254:267	herbal tablets	254:267	Core-shell composite particles (CPs) are the most preferred choice for direct compaction (DC), but their application in herbal tablets is limited.
32676863	6	64	theme	CP	917:918	arg1	X-H					920:922	(ii) CP X-H	912:922	(ii) CP X-H	912:922	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	6	65	theme	CP	874:875	arg1	X-P					877:879	CP X-P	874:879	CP X-P	874:879	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	8	66	theme	herbal	1576:1581	arg1	CPs					1594:1596	herbal core-shell CPs	1576:1596	herbal core-shell CPs for DC	1576:1603	These findings are beneficial to the development of herbal core-shell CPs for DC.
32676863	6	67	theme	better	944:949	arg1	compactibility					951:964	better compactibility	944:964	better compactibility	944:964	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	6	68	theme	disintegration	1243:1256	arg1	time					1258:1261	longer disintegration time	1236:1261	longer disintegration time	1236:1261	The results demonstrated that (i) CP X-H and CP X-P exhibited similar flowability; (ii) CP X-H generally exhibited better compactibility, larger particle size, and more uniform particle size distribution, and lower bulk density, tap density, and hygroscopicity than CP X-P; (iii) compared with the tablets produced with CP X-P, ones with CP X-H exhibited similar weight variation (%), lower friability, and longer disintegration time.
32676863	3	69	contain	containing	536:545	arg2	HPMC					547:550	HPMC	547:550	HPMC (CP X-H)	547:559	In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X).
32676863	3	69	contain	containing	536:545	arg1	CPs					532:534	the CPs	528:534	the CPs containing HPMC (CP X-H)	528:559	In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X).
32676863	3	69	contain	containing	536:545	arg2	X-H					556:558	CP X-H	553:558	CP X-H	553:558	In this study, the CPs containing HPMC (CP X-H) and CPs containing PVP (CP X-P) were prepared based on herbal powders (X).
32199025	0	0	theme	Cichorium	56:64	arg1	intybusL					66:73	the Fiber-Rich Cichorium intybusL	41:73	the Fiber-Rich Cichorium intybusL	41:73	Back to the Roots: Revisiting the Use of the Fiber-Rich Cichorium intybusL.
32199025	10	1	theme	historic	1146:1153	arg1	success					1155:1161	their historic success	1140:1161	their historic success in the human diet	1140:1179	Here, we summarize the composition of chicory roots to explain their historic success in the human diet.
32199025	7	2	theme	inulin	767:772	arg1	extraction					753:762	the extraction	749:762	the extraction of inulin	749:772	Nowaday, chicory roots are mainly applied as a source for the extraction of inulin, which is used as prebiotic fiber and food ingredient.
32199025	0	3	theme	Fiber-Rich	45:54	arg1	intybusL					66:73	the Fiber-Rich Cichorium intybusL	41:73	the Fiber-Rich Cichorium intybusL	41:73	Back to the Roots: Revisiting the Use of the Fiber-Rich Cichorium intybusL.
32199025	3	4	theme	complex	201:207	arg1	mixtures					209:216	complex mixtures	201:216	complex mixtures of fibers	201:226	Notably, complex mixtures of fibers have been found to improve metabolic health.
32199025	6	5	theme	complex	596:602	arg1	lactones					642:649	sesquiterpene lactones	628:649	sesquiterpene lactones that have been characterized in detail	628:688	Chicory roots consist of a mixture of inulin, pectin, and (hemi-)cellulose and also contain complex phytochemicals, such as sesquiterpene lactones that have been characterized in detail.
32199025	6	5	theme	complex	596:602	arg1	phytochemicals					604:617	complex phytochemicals	596:617	complex phytochemicals	596:617	Chicory roots consist of a mixture of inulin, pectin, and (hemi-)cellulose and also contain complex phytochemicals, such as sesquiterpene lactones that have been characterized in detail.
32199025	13	6	theme	roots	1621:1625	arg1	applications					1597:1608	the current and future applications	1574:1608	the current and future applications of chicory roots	1574:1625	Finally, we provide an overview of the current and future applications of chicory roots and their contribution to a fiber-rich diet.
32199025	12	7	theme	extracts	1507:1514	arg1	regulation					1465:1474	legal regulation	1459:1474	legal regulation	1459:1474	Hereby, we focus on the whole root in its complex, natural form, as well as in relation to its constituents, and discuss aspects regarding legal regulation and the safety of chicory root extracts for human consumption.
32199025	12	7	theme	extracts	1507:1514	arg1	safety					1484:1489	the safety	1480:1489	the safety of chicory root extracts for human consumption	1480:1536	Hereby, we focus on the whole root in its complex, natural form, as well as in relation to its constituents, and discuss aspects regarding legal regulation and the safety of chicory root extracts for human consumption.
32199025	5	8	theme	dry	492:494	arg1	weight					496:501	its dry weight	488:501	its dry weight	488:501	to be 1 of the vegetables with the highest fiber content, comprising nearly 90% of its dry weight.
32199025	6	9	contain	contain	588:594	arg1	roots					512:516	Chicory roots	504:516	Chicory roots	504:516	Chicory roots consist of a mixture of inulin, pectin, and (hemi-)cellulose and also contain complex phytochemicals, such as sesquiterpene lactones that have been characterized in detail.
32199025	6	9	contain	contain	588:594	arg2	lactones					642:649	sesquiterpene lactones	628:649	sesquiterpene lactones that have been characterized in detail	628:688	Chicory roots consist of a mixture of inulin, pectin, and (hemi-)cellulose and also contain complex phytochemicals, such as sesquiterpene lactones that have been characterized in detail.
32199025	6	9	contain	contain	588:594	arg2	phytochemicals					604:617	complex phytochemicals	596:617	complex phytochemicals	596:617	Chicory roots consist of a mixture of inulin, pectin, and (hemi-)cellulose and also contain complex phytochemicals, such as sesquiterpene lactones that have been characterized in detail.
32199025	9	10	theme	world	1070:1074	arg1	parts					1057:1061	various parts	1049:1061	various parts of the world	1049:1074	The whole root has been used for thousands of years for nutritional, medicinal, and other purposes, and it is still used in traditional dishes in various parts of the world.
32199025	9	11	theme	whole	907:911	arg1	root					913:916	The whole root	903:916	The whole root	903:916	The whole root has been used for thousands of years for nutritional, medicinal, and other purposes, and it is still used in traditional dishes in various parts of the world.
32199025	0	12	theme	intybusL	66:73	arg1	Use					34:36	the Use	30:36	the Use of the Fiber-Rich Cichorium intybusL	30:73	Back to the Roots: Revisiting the Use of the Fiber-Rich Cichorium intybusL.
32199025	9	13	theme	nutritional	959:969	arg1	purposes					993:1000	nutritional, medicinal, and other purposes	959:1000	nutritional, medicinal, and other purposes	959:1000	The whole root has been used for thousands of years for nutritional, medicinal, and other purposes, and it is still used in traditional dishes in various parts of the world.
32199025	7	14	theme	food	812:815	arg1	ingredient					817:826	prebiotic fiber and food ingredient	792:826	ingredient	817:826	Nowaday, chicory roots are mainly applied as a source for the extraction of inulin, which is used as prebiotic fiber and food ingredient.
32199025	7	14	theme	food	812:815	arg1	source					738:743	a source	736:743	a source	736:743	Nowaday, chicory roots are mainly applied as a source for the extraction of inulin, which is used as prebiotic fiber and food ingredient.
32199025	5	15	theme	vegetables	420:429	arg1	1					411:411	1	411:411	1	411:411	to be 1 of the vegetables with the highest fiber content, comprising nearly 90% of its dry weight.
32199025	5	15	theme	vegetables	420:429	arg1	vegetables					420:429	the vegetables	416:429	the vegetables	416:429	to be 1 of the vegetables with the highest fiber content, comprising nearly 90% of its dry weight.
32199025	11	16	theme	roots	1215:1219	arg1	intake					1197:1202	the intake	1193:1202	the intake of chicory roots	1193:1219	We revisit the intake of chicory roots by humans and describe the different types of use along with their various methods of preparation.
32199025	2	17	theme	indispensable	127:139	arg1	Fibers					86:91	Fibers	86:91	Fibers	86:91	Fibers are increasingly recognized as an indispensable part of our diet and vital for maintaining health.
32199025	2	17	theme	indispensable	127:139	arg1	part					141:144	an indispensable part	124:144	an indispensable part of our diet	124:156	Fibers are increasingly recognized as an indispensable part of our diet and vital for maintaining health.
32199025	3	18	theme	fibers	221:226	arg1	mixtures					209:216	complex mixtures	201:216	complex mixtures of fibers	201:226	Notably, complex mixtures of fibers have been found to improve metabolic health.
32199025	10	19	theme	human	1170:1174	arg1	diet					1176:1179	the human diet	1166:1179	the human diet	1166:1179	Here, we summarize the composition of chicory roots to explain their historic success in the human diet.
32199025	9	20	used	used	1019:1022	arg2	it					1007:1008	it	1007:1008	it	1007:1008	The whole root has been used for thousands of years for nutritional, medicinal, and other purposes, and it is still used in traditional dishes in various parts of the world.
32199025	12	21	theme	legal	1459:1463	arg1	regulation					1465:1474	legal regulation	1459:1474	legal regulation	1459:1474	Hereby, we focus on the whole root in its complex, natural form, as well as in relation to its constituents, and discuss aspects regarding legal regulation and the safety of chicory root extracts for human consumption.
32199025	13	22	theme	future	1590:1595	arg1	applications					1597:1608	the current and future applications	1574:1608	the current and future applications of chicory roots	1574:1625	Finally, we provide an overview of the current and future applications of chicory roots and their contribution to a fiber-rich diet.
32199025	12	23	dep	complex	1362:1368	arg1	natural					1371:1377	natural	1371:1377	natural	1371:1377	Hereby, we focus on the whole root in its complex, natural form, as well as in relation to its constituents, and discuss aspects regarding legal regulation and the safety of chicory root extracts for human consumption.
32199025	11	24	theme	various	1288:1294	arg1	methods					1296:1302	their various methods	1282:1302	their various methods of preparation	1282:1317	We revisit the intake of chicory roots by humans and describe the different types of use along with their various methods of preparation.
32199025	13	25	theme	chicory	1613:1619	arg1	roots					1621:1625	chicory roots	1613:1625	chicory roots	1613:1625	Finally, we provide an overview of the current and future applications of chicory roots and their contribution to a fiber-rich diet.
32199025	11	26	theme	chicory	1207:1213	arg1	roots					1215:1219	chicory roots	1207:1219	chicory roots	1207:1219	We revisit the intake of chicory roots by humans and describe the different types of use along with their various methods of preparation.
32199025	4	27	theme	products	331:338	arg1	content					308:314	the fiber content	298:314	the fiber content of plant-based products	298:338	Following an analysis of the fiber content of plant-based products, we found the taproot of the chicory plant (Cichorium intybusL.)
32199025	5	28	theme	highest	440:446	arg1	content					454:460	the highest fiber content	436:460	the highest fiber content	436:460	to be 1 of the vegetables with the highest fiber content, comprising nearly 90% of its dry weight.
32199025	12	29	theme	complex	1362:1368	arg1	form					1379:1382	its complex, natural form	1358:1382	its complex, natural form	1358:1382	Hereby, we focus on the whole root in its complex, natural form, as well as in relation to its constituents, and discuss aspects regarding legal regulation and the safety of chicory root extracts for human consumption.
32199025	5	30	theme	weight	496:501	arg1	weight					496:501	its dry weight	488:501	its dry weight	488:501	to be 1 of the vegetables with the highest fiber content, comprising nearly 90% of its dry weight.
32199025	5	30	theme	weight	496:501	arg1	%					483:483	nearly 90%	474:483	nearly 90% of its dry weight	474:501	to be 1 of the vegetables with the highest fiber content, comprising nearly 90% of its dry weight.
32199025	6	31	theme	cellulose	569:577	arg1	mixture					531:537	a mixture	529:537	a mixture of inulin, pectin, and (hemi-)cellulose	529:577	Chicory roots consist of a mixture of inulin, pectin, and (hemi-)cellulose and also contain complex phytochemicals, such as sesquiterpene lactones that have been characterized in detail.
32199025	4	32	theme	intybusL	394:401	arg1	taproot					354:360	the taproot	350:360	the taproot of the chicory plant (Cichorium intybusL	350:401	Following an analysis of the fiber content of plant-based products, we found the taproot of the chicory plant (Cichorium intybusL.)
32199025	7	33	theme	chicory	700:706	arg1	roots					708:712	chicory roots	700:712	chicory roots	700:712	Nowaday, chicory roots are mainly applied as a source for the extraction of inulin, which is used as prebiotic fiber and food ingredient.
32199025	7	33	theme	chicory	700:706	arg1	source					738:743	a source	736:743	a source	736:743	Nowaday, chicory roots are mainly applied as a source for the extraction of inulin, which is used as prebiotic fiber and food ingredient.
32199025	7	34	theme	prebiotic	792:800	arg1	fiber					802:806	prebiotic fiber and food ingredient	792:826	fiber	802:806	Nowaday, chicory roots are mainly applied as a source for the extraction of inulin, which is used as prebiotic fiber and food ingredient.
32199025	7	34	theme	prebiotic	792:800	arg1	source					738:743	a source	736:743	a source	736:743	Nowaday, chicory roots are mainly applied as a source for the extraction of inulin, which is used as prebiotic fiber and food ingredient.
32199025	11	35	theme	different	1248:1256	arg1	types					1258:1262	the different types	1244:1262	the different types of use	1244:1269	We revisit the intake of chicory roots by humans and describe the different types of use along with their various methods of preparation.
32199025	9	36	used	used	927:930	arg2	root					913:916	The whole root	903:916	The whole root	903:916	The whole root has been used for thousands of years for nutritional, medicinal, and other purposes, and it is still used in traditional dishes in various parts of the world.
32199025	6	37	theme	Chicory	504:510	arg1	roots					512:516	Chicory roots	504:516	Chicory roots	504:516	Chicory roots consist of a mixture of inulin, pectin, and (hemi-)cellulose and also contain complex phytochemicals, such as sesquiterpene lactones that have been characterized in detail.
32199025	7	38	used	used	784:787	arg2	roots					708:712	chicory roots	700:712	chicory roots	700:712	Nowaday, chicory roots are mainly applied as a source for the extraction of inulin, which is used as prebiotic fiber and food ingredient.
32199025	7	38	used	used	784:787	arg2	ingredient					817:826	prebiotic fiber and food ingredient	792:826	ingredient	817:826	Nowaday, chicory roots are mainly applied as a source for the extraction of inulin, which is used as prebiotic fiber and food ingredient.
32199025	7	38	used	used	784:787	arg2	source					738:743	a source	736:743	a source	736:743	Nowaday, chicory roots are mainly applied as a source for the extraction of inulin, which is used as prebiotic fiber and food ingredient.
32199025	7	38	used	used	784:787	arg2	fiber					802:806	prebiotic fiber and food ingredient	792:826	fiber	802:806	Nowaday, chicory roots are mainly applied as a source for the extraction of inulin, which is used as prebiotic fiber and food ingredient.
32199025	6	39	theme	hemi-	563:567	arg1	cellulose					569:577	(hemi-)cellulose	562:577	(hemi-)cellulose	562:577	Chicory roots consist of a mixture of inulin, pectin, and (hemi-)cellulose and also contain complex phytochemicals, such as sesquiterpene lactones that have been characterized in detail.
32199025	10	40	theme	chicory	1115:1121	arg1	roots					1123:1127	chicory roots	1115:1127	chicory roots	1115:1127	Here, we summarize the composition of chicory roots to explain their historic success in the human diet.
32199025	2	41	theme	diet	153:156	arg1	Fibers					86:91	Fibers	86:91	Fibers	86:91	Fibers are increasingly recognized as an indispensable part of our diet and vital for maintaining health.
32199025	2	41	theme	diet	153:156	arg1	part					141:144	an indispensable part	124:144	an indispensable part of our diet	124:156	Fibers are increasingly recognized as an indispensable part of our diet and vital for maintaining health.
32199025	9	42	theme	years	949:953	arg1	thousands					936:944	thousands	936:944	thousands of years for nutritional, medicinal, and other purposes	936:1000	The whole root has been used for thousands of years for nutritional, medicinal, and other purposes, and it is still used in traditional dishes in various parts of the world.
32199025	13	43	theme	applications	1597:1608	arg1	contribution					1637:1648	their contribution	1631:1648	their contribution to a fiber-rich diet	1631:1669	Finally, we provide an overview of the current and future applications of chicory roots and their contribution to a fiber-rich diet.
32199025	13	43	theme	applications	1597:1608	arg1	overview					1562:1569	an overview	1559:1569	an overview of the current and future applications of chicory roots	1559:1625	Finally, we provide an overview of the current and future applications of chicory roots and their contribution to a fiber-rich diet.
32199025	12	44	theme	whole	1344:1348	arg1	root					1350:1353	the whole root	1340:1353	the whole root in its complex, natural form, as well as in relation to its constituents	1340:1426	Hereby, we focus on the whole root in its complex, natural form, as well as in relation to its constituents, and discuss aspects regarding legal regulation and the safety of chicory root extracts for human consumption.
32199025	12	45	theme	root	1502:1505	arg1	extracts					1507:1514	chicory root extracts	1494:1514	chicory root extracts	1494:1514	Hereby, we focus on the whole root in its complex, natural form, as well as in relation to its constituents, and discuss aspects regarding legal regulation and the safety of chicory root extracts for human consumption.
32199025	9	46	theme	various	1049:1055	arg1	parts					1057:1061	various parts	1049:1061	various parts of the world	1049:1074	The whole root has been used for thousands of years for nutritional, medicinal, and other purposes, and it is still used in traditional dishes in various parts of the world.
32199025	13	47	theme	current	1578:1584	arg1	applications					1597:1608	the current and future applications	1574:1608	the current and future applications of chicory roots	1574:1625	Finally, we provide an overview of the current and future applications of chicory roots and their contribution to a fiber-rich diet.
32199025	4	48	theme	content	308:314	arg1	analysis					286:293	an analysis	283:293	an analysis of the fiber content of plant-based products	283:338	Following an analysis of the fiber content of plant-based products, we found the taproot of the chicory plant (Cichorium intybusL.)
32199025	4	49	theme	fiber	302:306	arg1	content					308:314	the fiber content	298:314	the fiber content of plant-based products	298:338	Following an analysis of the fiber content of plant-based products, we found the taproot of the chicory plant (Cichorium intybusL.)
32199025	12	50	theme	chicory	1494:1500	arg1	extracts					1507:1514	chicory root extracts	1494:1514	chicory root extracts	1494:1514	Hereby, we focus on the whole root in its complex, natural form, as well as in relation to its constituents, and discuss aspects regarding legal regulation and the safety of chicory root extracts for human consumption.
32199025	12	51	from	root	1350:1353	arg1	form					1379:1382	its complex, natural form	1358:1382	its complex, natural form	1358:1382	Hereby, we focus on the whole root in its complex, natural form, as well as in relation to its constituents, and discuss aspects regarding legal regulation and the safety of chicory root extracts for human consumption.
32199025	12	51	from	root	1350:1353	arg1	relation					1399:1406	relation	1399:1406	relation to its constituents	1399:1426	Hereby, we focus on the whole root in its complex, natural form, as well as in relation to its constituents, and discuss aspects regarding legal regulation and the safety of chicory root extracts for human consumption.
32199025	4	52	theme	plant	377:381	arg1	intybusL					394:401	the chicory plant (Cichorium intybusL	365:401	the chicory plant (Cichorium intybusL	365:401	Following an analysis of the fiber content of plant-based products, we found the taproot of the chicory plant (Cichorium intybusL.)
32199025	4	53	theme	plant-based	319:329	arg1	products					331:338	plant-based products	319:338	plant-based products	319:338	Following an analysis of the fiber content of plant-based products, we found the taproot of the chicory plant (Cichorium intybusL.)
32199025	11	54	theme	use	1267:1269	arg1	types					1258:1262	the different types	1244:1262	the different types of use	1244:1269	We revisit the intake of chicory roots by humans and describe the different types of use along with their various methods of preparation.
32199025	9	55	theme	traditional	1027:1037	arg1	dishes					1039:1044	traditional dishes	1027:1044	traditional dishes	1027:1044	The whole root has been used for thousands of years for nutritional, medicinal, and other purposes, and it is still used in traditional dishes in various parts of the world.
32199025	3	56	theme	metabolic	255:263	arg1	health					265:270	metabolic health	255:270	metabolic health	255:270	Notably, complex mixtures of fibers have been found to improve metabolic health.
32199025	4	57	theme	chicory	369:375	arg1	intybusL					394:401	the chicory plant (Cichorium intybusL	365:401	the chicory plant (Cichorium intybusL	365:401	Following an analysis of the fiber content of plant-based products, we found the taproot of the chicory plant (Cichorium intybusL.)
32199025	0	58	dep	Roots	12:16	arg1	Revisiting					19:28	Revisiting	19:28	Revisiting the Use of the Fiber-Rich Cichorium intybusL	19:73	Back to the Roots: Revisiting the Use of the Fiber-Rich Cichorium intybusL.
32199025	6	59	theme	sesquiterpene	628:640	arg1	lactones					642:649	sesquiterpene lactones	628:649	sesquiterpene lactones that have been characterized in detail	628:688	Chicory roots consist of a mixture of inulin, pectin, and (hemi-)cellulose and also contain complex phytochemicals, such as sesquiterpene lactones that have been characterized in detail.
32199025	9	60	theme	other	987:991	arg1	purposes					993:1000	nutritional, medicinal, and other purposes	959:1000	nutritional, medicinal, and other purposes	959:1000	The whole root has been used for thousands of years for nutritional, medicinal, and other purposes, and it is still used in traditional dishes in various parts of the world.
32199025	9	61	theme	medicinal	972:980	arg1	purposes					993:1000	nutritional, medicinal, and other purposes	959:1000	nutritional, medicinal, and other purposes	959:1000	The whole root has been used for thousands of years for nutritional, medicinal, and other purposes, and it is still used in traditional dishes in various parts of the world.
32199025	4	62	theme	Cichorium	384:392	arg1	intybusL					394:401	the chicory plant (Cichorium intybusL	365:401	the chicory plant (Cichorium intybusL	365:401	Following an analysis of the fiber content of plant-based products, we found the taproot of the chicory plant (Cichorium intybusL.)
32199025	0	63	dep	the	8:10	arg1	to					5:6	to	5:6	to	5:6	Back to the Roots: Revisiting the Use of the Fiber-Rich Cichorium intybusL.
32199025	5	64	theme	fiber	448:452	arg1	content					454:460	the highest fiber content	436:460	the highest fiber content	436:460	to be 1 of the vegetables with the highest fiber content, comprising nearly 90% of its dry weight.
32199025	6	65	theme	pectin	550:555	arg1	mixture					531:537	a mixture	529:537	a mixture of inulin, pectin, and (hemi-)cellulose	529:577	Chicory roots consist of a mixture of inulin, pectin, and (hemi-)cellulose and also contain complex phytochemicals, such as sesquiterpene lactones that have been characterized in detail.
32199025	10	66	theme	roots	1123:1127	arg1	composition					1100:1110	the composition	1096:1110	the composition of chicory roots to explain their historic success in the human diet	1096:1179	Here, we summarize the composition of chicory roots to explain their historic success in the human diet.
32199025	10	67	from	success	1155:1161	arg1	diet					1176:1179	the human diet	1166:1179	the human diet	1166:1179	Here, we summarize the composition of chicory roots to explain their historic success in the human diet.
32199025	12	68	theme	human	1520:1524	arg1	consumption					1526:1536	human consumption	1520:1536	human consumption	1520:1536	Hereby, we focus on the whole root in its complex, natural form, as well as in relation to its constituents, and discuss aspects regarding legal regulation and the safety of chicory root extracts for human consumption.
32199025	13	69	theme	fiber-rich	1655:1664	arg1	diet					1666:1669	a fiber-rich diet	1653:1669	a fiber-rich diet	1653:1669	Finally, we provide an overview of the current and future applications of chicory roots and their contribution to a fiber-rich diet.
32199025	8	70	theme	Chicory	829:835	arg1	vegetable					882:890	a vegetable	880:890	a vegetable by humans	880:900	Chicory roots, however, have long been consumed as a vegetable by humans.
32199025	8	70	theme	Chicory	829:835	arg1	roots					837:841	Chicory roots	829:841	Chicory roots	829:841	Chicory roots, however, have long been consumed as a vegetable by humans.
32199025	6	71	theme	inulin	542:547	arg1	mixture					531:537	a mixture	529:537	a mixture of inulin, pectin, and (hemi-)cellulose	529:577	Chicory roots consist of a mixture of inulin, pectin, and (hemi-)cellulose and also contain complex phytochemicals, such as sesquiterpene lactones that have been characterized in detail.
32199025	11	72	theme	preparation	1307:1317	arg1	methods					1296:1302	their various methods	1282:1302	their various methods of preparation	1282:1317	We revisit the intake of chicory roots by humans and describe the different types of use along with their various methods of preparation.
34822831	1	0	with	flours	259:264	arg1	strength					288:295	different gluten strength	271:295	different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles	271:362	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	1	1	theme	gluten	281:286	arg1	strength					288:295	different gluten strength	271:295	different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles	271:362	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	0	2	theme	structural	81:90	arg1	characteristics					92:106	structural characteristics	81:106	structural characteristics	81:106	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	2	3	theme	concave	598:604	arg1	hole					606:609	concave hole	598:609	concave hole	598:609	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	1	4	theme	physicochemical	172:186	arg1	properties					188:197	physicochemical properties	172:197	physicochemical properties	172:197	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	4	5	theme	dough	1092:1096	arg1	industry					1098:1105	frozen dough industry	1085:1105	frozen dough industry	1085:1105	This study provides theoretical contribution to the development of frozen dough industry from the perspective of wheat variety.
34822831	0	6	theme	starch	111:116	arg1	properties					66:75	physicochemical properties	50:75	physicochemical properties	50:75	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	0	6	theme	starch	111:116	arg1	characteristics					92:106	structural characteristics	81:106	structural characteristics	81:106	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	0	7	from	Effect	0:5	arg1	properties					66:75	physicochemical properties	50:75	physicochemical properties	50:75	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	0	7	from	Effect	0:5	arg1	characteristics					92:106	structural characteristics	81:106	structural characteristics	81:106	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	2	8	theme	surface	590:596	arg1	distribution					565:576	the most serious distribution	548:576	the most serious distribution of particle surface concave hole and fracture	548:622	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	8	theme	surface	590:596	arg1	S-YM20					628:633	S-YM20	628:633	S-YM20	628:633	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	9	theme	solubility	697:706	arg1	results					686:692	the results	682:692	the results of solubility, swelling power, thermal stability and pasting properties	682:764	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	10	theme	particle	581:588	arg1	surface					590:596	particle surface concave hole and fracture	581:622	surface	590:596	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	11	theme	content	508:514	arg1	increment					480:488	the lowest increment	469:488	the lowest increment of damaged starch content after 8 F/T cycles	469:533	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	11	theme	content	508:514	arg1	S-ZM366					539:545	S-ZM366	539:545	S-ZM366	539:545	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	12	theme	swelling	709:716	arg1	power					718:722	swelling power	709:722	swelling power	709:722	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	4	13	theme	frozen	1085:1090	arg1	industry					1098:1105	frozen dough industry	1085:1105	frozen dough industry	1085:1105	This study provides theoretical contribution to the development of frozen dough industry from the perspective of wheat variety.
34822831	2	14	theme	stability	733:741	arg1	results					686:692	the results	682:692	the results of solubility, swelling power, thermal stability and pasting properties	682:764	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	15	theme	starch	501:506	arg1	content					508:514	damaged starch content	493:514	damaged starch content	493:514	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	4	16	theme	theoretical	1038:1048	arg1	contribution					1050:1061	theoretical contribution	1038:1061	theoretical contribution to the development of frozen dough industry from the perspective of wheat variety	1038:1143	This study provides theoretical contribution to the development of frozen dough industry from the perspective of wheat variety.
34822831	2	17	theme	thermal	725:731	arg1	stability					733:741	thermal stability	725:741	thermal stability	725:741	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	18	theme	lowest	473:478	arg1	increment					480:488	the lowest increment	469:488	the lowest increment of damaged starch content after 8 F/T cycles	469:533	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	18	theme	lowest	473:478	arg1	S-ZM366					539:545	S-ZM366	539:545	S-ZM366	539:545	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	19	theme	fracture	615:622	arg1	distribution					565:576	the most serious distribution	548:576	the most serious distribution of particle surface concave hole and fracture	548:622	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	19	theme	fracture	615:622	arg1	S-YM20					628:633	S-YM20	628:633	S-YM20	628:633	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	1	20	theme	structural	203:212	arg1	characteristics					214:228	structural characteristics	203:228	structural characteristics	203:228	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	2	21	theme	starches	441:448	arg1	content					418:424	the damaged starch content	399:424	the damaged starch content of these three starches	399:448	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	4	22	theme	variety	1137:1143	arg1	perspective					1116:1126	the perspective	1112:1126	the perspective of wheat variety	1112:1143	This study provides theoretical contribution to the development of frozen dough industry from the perspective of wheat variety.
34822831	4	23	theme	wheat	1131:1135	arg1	variety					1137:1143	wheat variety	1131:1143	wheat variety	1131:1143	This study provides theoretical contribution to the development of frozen dough industry from the perspective of wheat variety.
34822831	2	24	theme	F/T	384:386	arg1	treatment					388:396	F/T treatment	384:396	F/T treatment	384:396	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	0	25	theme	freezing/thawing	19:34	arg1	cycles					36:41	multiple freezing/thawing cycles	10:41	multiple freezing/thawing cycles	10:41	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	0	26	theme	multiple	10:17	arg1	cycles					36:41	multiple freezing/thawing cycles	10:41	multiple freezing/thawing cycles	10:41	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	4	27	theme	industry	1098:1105	arg1	development					1070:1080	the development	1066:1080	the development of frozen dough industry	1066:1105	This study provides theoretical contribution to the development of frozen dough industry from the perspective of wheat variety.
34822831	0	28	from	characteristics	92:106	arg1	wheat					123:127	wheat	123:127	wheat	123:127	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	0	29	dep	properties	66:75	arg1	the					46:48	the	46:48	the	46:48	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	2	30	theme	properties	755:764	arg1	results					686:692	the results	682:692	the results of solubility, swelling power, thermal stability and pasting properties	682:764	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	1	31	theme	starches	233:240	arg1	properties					188:197	physicochemical properties	172:197	physicochemical properties	172:197	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	1	31	theme	starches	233:240	arg1	characteristics					214:228	structural characteristics	203:228	structural characteristics	203:228	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	2	32	dep	surface	590:596	arg1	hole					606:609	concave hole	598:609	concave hole	598:609	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	0	33	theme	gluten	151:156	arg1	strength					158:165	different gluten strength	141:165	different gluten strength	141:165	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	2	34	theme	pasting	747:753	arg1	properties					755:764	pasting properties	747:764	pasting properties	747:764	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	35	theme	starch	411:416	arg1	content					418:424	the damaged starch content	399:424	the damaged starch content of these three starches	399:448	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	0	36	theme	cycles	36:41	arg1	Effect					0:5	Effect	0:5	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat	0:127	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	0	37	theme	different	141:149	arg1	strength					158:165	different gluten strength	141:165	different gluten strength	141:165	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	3	38	from	differences	928:938	arg1	microstructure					975:988	microstructure	975:988	microstructure	975:988	The differences of freezing resistance among the three starches were possibly ascribed to the differences in compositions, crystallinity and microstructure among these three starches.
34822831	3	38	from	differences	928:938	arg1	crystallinity					957:969	crystallinity	957:969	crystallinity	957:969	The differences of freezing resistance among the three starches were possibly ascribed to the differences in compositions, crystallinity and microstructure among these three starches.
34822831	3	38	from	differences	928:938	arg1	compositions					943:954	compositions	943:954	compositions	943:954	The differences of freezing resistance among the three starches were possibly ascribed to the differences in compositions, crystallinity and microstructure among these three starches.
34822831	2	39	theme	damaged	403:409	arg1	content					418:424	the damaged starch content	399:424	the damaged starch content of these three starches	399:448	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	0	40	theme	physicochemical	50:64	arg1	properties					66:75	physicochemical properties	50:75	physicochemical properties	50:75	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	2	41	dep	S-ZM366	539:545	arg1	indicated					766:774	indicated	766:774	indicated S-ZM366 exhibited the strongest resistance to F/T cycles	766:831	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	0	42	from	properties	66:75	arg1	wheat					123:127	wheat	123:127	wheat	123:127	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	1	43	dep	properties	188:197	arg1	The					168:170	The	168:170	The	168:170	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	4	44	from	perspective	1116:1126	arg1	contribution					1050:1061	theoretical contribution	1038:1061	theoretical contribution to the development of frozen dough industry from the perspective of wheat variety	1038:1143	This study provides theoretical contribution to the development of frozen dough industry from the perspective of wheat variety.
34822831	0	45	from	wheat	123:127	arg1	starch					111:116	starch	111:116	starch from wheat	111:127	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	0	45	from	wheat	123:127	arg1	properties					66:75	physicochemical properties	50:75	physicochemical properties	50:75	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	0	45	from	wheat	123:127	arg1	characteristics					92:106	structural characteristics	81:106	structural characteristics	81:106	Effect of multiple freezing/thawing cycles on the physicochemical properties and structural characteristics of starch from wheat flours with different gluten strength.
34822831	3	46	theme	freezing	853:860	arg1	resistance					862:871	freezing resistance	853:871	freezing resistance	853:871	The differences of freezing resistance among the three starches were possibly ascribed to the differences in compositions, crystallinity and microstructure among these three starches.
34822831	1	47	theme	freezing/thawing	334:349	arg1	cycles					357:362	freezing/thawing (F/T) cycles	334:362	freezing/thawing (F/T) cycles	334:362	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	1	47	theme	freezing/thawing	334:349	arg1	F/T					352:354	F/T	352:354	F/T	352:354	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	2	48	theme	serious	557:563	arg1	distribution					565:576	the most serious distribution	548:576	the most serious distribution of particle surface concave hole and fracture	548:622	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	48	theme	serious	557:563	arg1	S-YM20					628:633	S-YM20	628:633	S-YM20	628:633	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	49	theme	strongest	798:806	arg1	resistance					808:817	the strongest resistance	794:817	the strongest resistance to F/T cycles	794:831	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	1	50	theme	wheat	253:257	arg1	flours					259:264	three wheat flours	247:264	three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles	247:362	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	1	51	from	flours	259:264	arg1	starches					233:240	starches	233:240	starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles	233:362	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	1	51	from	flours	259:264	arg1	properties					188:197	physicochemical properties	172:197	physicochemical properties	172:197	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	1	51	from	flours	259:264	arg1	characteristics					214:228	structural characteristics	203:228	structural characteristics	203:228	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	2	52	theme	power	718:722	arg1	results					686:692	the results	682:692	the results of solubility, swelling power, thermal stability and pasting properties	682:764	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	2	53	theme	damaged	493:499	arg1	content					508:514	damaged starch content	493:514	damaged starch content	493:514	After F/T treatment, the damaged starch content of these three starches all increased, and the lowest increment of damaged starch content after 8 F/T cycles was S-ZM366; the most serious distribution of particle surface concave hole and fracture was S-YM20, followed by S-ZM27 and S-ZM366; additionally, the results of solubility, swelling power, thermal stability and pasting properties indicated S-ZM366 exhibited the strongest resistance to F/T cycles.
34822831	1	54	dep	strength	288:295	arg1	S-ZM27					306:311	S-ZM27	306:311	S-ZM27	306:311	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	1	54	dep	strength	288:295	arg1	S-ZM366					318:324	S-ZM366	318:324	S-ZM366	318:324	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	1	54	dep	strength	288:295	arg1	S-YM20					298:303	S-YM20	298:303	S-YM20	298:303	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	1	55	from	characteristics	214:228	arg1	flours					259:264	three wheat flours	247:264	three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles	247:362	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	3	56	theme	resistance	862:871	arg1	differences					838:848	The differences	834:848	The differences of freezing resistance among the three starches	834:896	The differences of freezing resistance among the three starches were possibly ascribed to the differences in compositions, crystallinity and microstructure among these three starches.
34822831	1	57	from	properties	188:197	arg1	flours					259:264	three wheat flours	247:264	three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles	247:362	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34822831	1	58	theme	different	271:279	arg1	strength					288:295	different gluten strength	271:295	different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles	271:362	The physicochemical properties and structural characteristics of starches from three wheat flours with different gluten strength (S-YM20, S-ZM27, and S-ZM366) during freezing/thawing (F/T) cycles were studied.
34280442	9	0	theme	physical	1176:1183	arg1	interactions					1185:1196	physical interactions	1176:1196	physical interactions (i.e., adsorption energy <40 kJ/mol)	1176:1233	Energetically, Mn(VII) uptake by Cs/Ac was governed by physical interactions (i.e., adsorption energy <40 kJ/mol).
34280442	11	1	theme	adsorption	1500:1509	arg1	mechanism					1511:1519	the adsorption mechanism	1496:1519	the adsorption mechanism	1496:1519	Overall, modification of the Ac by the used marine biomass (Cs) produced a promising Mn(VII) adsorbent and also, the application of physical analysis offered a deep interpretation for the adsorption mechanism.
34280442	4	2	theme	achieved	538:545	arg1	data					560:563	the achieved experimental data	534:563	the achieved experimental data	534:563	The Freundlich equation described well the achieved experimental data at all temperatures.
34280442	9	3	dep	<40 kJ/mol	1223:1232	arg1	i.e.					1199:1202	i.e.	1199:1202	i.e.	1199:1202	Energetically, Mn(VII) uptake by Cs/Ac was governed by physical interactions (i.e., adsorption energy <40 kJ/mol).
34280442	6	4	theme	double	784:789	arg1	model					797:801	the double layer model	780:801	the double layer model with two energy sites (i.e., the best fit statistical model)	780:862	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	6	5	dep	Steric	735:740	arg1	data					772:775	data	772:775	data	772:775	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	2	6	dep	temperatures	359:370	arg1	i.e.					373:376	i.e.	373:376	i.e.	373:376	The resulted Cs/Ac was characterized and utilized as a cost-effective adsorbent for Mn(VII) at altered temperatures (i.e., 25, 35, and 45 °C).
34280442	7	7	theme	mechanisms	1028:1037	arg1	presence					979:986	the presence	975:986	the presence of multi-docking and multi-interactions mechanisms	975:1037	The number of Mn(VII) per adsorption site (n) was between 0.76 and 0.92 suggested the presence of multi-docking and multi-interactions mechanisms.
34280442	11	8	theme	physical	1444:1451	arg1	analysis					1453:1460	physical analysis	1444:1460	physical analysis	1444:1460	Overall, modification of the Ac by the used marine biomass (Cs) produced a promising Mn(VII) adsorbent and also, the application of physical analysis offered a deep interpretation for the adsorption mechanism.
34280442	6	9	theme	fit	841:843	arg1	model					857:861	the best fit statistical model	832:861	the best fit statistical model	832:861	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	6	9	theme	fit	841:843	arg1	sites					819:823	two energy sites	808:823	two energy sites (i.e., the best fit statistical model)	808:862	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	4	10	theme	experimental	547:558	arg1	data					560:563	the achieved experimental data	534:563	the achieved experimental data	534:563	The Freundlich equation described well the achieved experimental data at all temperatures.
34280442	8	11	theme	Cs/Ac	1077:1081	arg1	sites					1051:1055	The active sites density (NM)	1040:1068	The active sites density (NM) of the Cs/Ac	1040:1081	The active sites density (NM) of the Cs/Ac decreased with improving temperature.
34280442	8	11	theme	Cs/Ac	1077:1081	arg1	Cs/Ac					1077:1081	the Cs/Ac	1073:1081	the Cs/Ac	1073:1081	The active sites density (NM) of the Cs/Ac decreased with improving temperature.
34280442	6	12	theme	best	836:839	arg1	model					857:861	the best fit statistical model	832:861	the best fit statistical model	832:861	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	6	12	theme	best	836:839	arg1	sites					819:823	two energy sites	808:823	two energy sites (i.e., the best fit statistical model)	808:862	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	3	13	theme	physics	479:485	arg1	models					487:492	classical as well as advanced statistical physics models	437:492	classical as well as advanced statistical physics models	437:492	The adsorption results were fitted to classical as well as advanced statistical physics models.
34280442	1	14	theme	porous	162:167	arg1	coal					179:182	porous activated coal	162:182	porous activated coal	162:182	Chitosan was impregnated into porous activated coal to produce a multifunctional chitosan/activated coal (Cs/Ac) composite.
34280442	9	15	theme	adsorption	1205:1214	arg1	<40 kJ/mol					1223:1232	adsorption energy <40 kJ/mol	1205:1232	adsorption energy <40 kJ/mol	1205:1232	Energetically, Mn(VII) uptake by Cs/Ac was governed by physical interactions (i.e., adsorption energy <40 kJ/mol).
34280442	6	16	dep	model	857:861	arg1	i.e.					826:829	i.e.	826:829	i.e.	826:829	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	1	17	theme	activated	169:177	arg1	coal					179:182	porous activated coal	162:182	porous activated coal	162:182	Chitosan was impregnated into porous activated coal to produce a multifunctional chitosan/activated coal (Cs/Ac) composite.
34280442	0	18	theme	coal	19:22	arg1	composite					24:32	Chitosan/activated coal composite	0:32	Chitosan/activated coal composite as an effective adsorbent for Mn(VII): Modeling and interpretation of physicochemical parameters.	0:130	Chitosan/activated coal composite as an effective adsorbent for Mn(VII): Modeling and interpretation of physicochemical parameters.
34280442	9	19	theme	energy	1216:1221	arg1	<40 kJ/mol					1223:1232	adsorption energy <40 kJ/mol	1205:1232	adsorption energy <40 kJ/mol	1205:1232	Energetically, Mn(VII) uptake by Cs/Ac was governed by physical interactions (i.e., adsorption energy <40 kJ/mol).
34280442	5	20	theme	Langmuir	600:607	arg1	adsorption					609:618	Langmuir adsorption	600:618	the Langmuir adsorption capacity from 203.26 to 224.03 mg/g	596:654	Enhancing the Langmuir adsorption capacity from 203.26 to 224.03 mg/g with temperature indicated that Mn(VII) adsorption was an endothermic process.
34280442	8	21	dep	sites	1051:1055	arg1	NM					1066:1067	NM	1066:1067	NM	1066:1067	The active sites density (NM) of the Cs/Ac decreased with improving temperature.
34280442	8	21	dep	sites	1051:1055	arg1	density					1057:1063	density	1057:1063	The active sites density (NM) of the Cs/Ac	1040:1081	The active sites density (NM) of the Cs/Ac decreased with improving temperature.
34280442	0	22	theme	Chitosan/activated	0:17	arg1	composite					24:32	Chitosan/activated coal composite	0:32	Chitosan/activated coal composite as an effective adsorbent for Mn(VII): Modeling and interpretation of physicochemical parameters.	0:130	Chitosan/activated coal composite as an effective adsorbent for Mn(VII): Modeling and interpretation of physicochemical parameters.
34280442	5	23	theme	adsorption	609:618	arg1	capacity					620:627	the Langmuir adsorption capacity	596:627	the Langmuir adsorption capacity from 203.26 to 224.03 mg/g	596:654	Enhancing the Langmuir adsorption capacity from 203.26 to 224.03 mg/g with temperature indicated that Mn(VII) adsorption was an endothermic process.
34280442	11	24	theme	Ac	1341:1342	arg1	modification					1321:1332	modification	1321:1332	modification of the Ac by the used marine biomass (Cs)	1321:1374	Overall, modification of the Ac by the used marine biomass (Cs) produced a promising Mn(VII) adsorbent and also, the application of physical analysis offered a deep interpretation for the adsorption mechanism.
34280442	4	25	theme	Freundlich	499:508	arg1	equation					510:517	The Freundlich equation	495:517	The Freundlich equation	495:517	The Freundlich equation described well the achieved experimental data at all temperatures.
34280442	0	26	theme	physicochemical	104:118	arg1	parameters					120:129	physicochemical parameters	104:129	physicochemical parameters	104:129	Chitosan/activated coal composite as an effective adsorbent for Mn(VII): Modeling and interpretation of physicochemical parameters.
34280442	9	27	theme	Mn	1136:1137	arg1	uptake					1144:1149	Mn(VII) uptake	1136:1149	Mn(VII) uptake by Cs/Ac	1136:1158	Energetically, Mn(VII) uptake by Cs/Ac was governed by physical interactions (i.e., adsorption energy <40 kJ/mol).
34280442	7	28	theme	Mn	907:908	arg1	number					897:902	The number	893:902	The number of Mn(VII) per adsorption site (n) was between 0.76 and 0.92	893:963	The number of Mn(VII) per adsorption site (n) was between 0.76 and 0.92 suggested the presence of multi-docking and multi-interactions mechanisms.
34280442	6	29	theme	statistical	845:855	arg1	model					857:861	the best fit statistical model	832:861	the best fit statistical model	832:861	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	6	29	theme	statistical	845:855	arg1	sites					819:823	two energy sites	808:823	two energy sites (i.e., the best fit statistical model)	808:862	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	7	30	theme	adsorption	919:928	arg1	n					936:936	n	936:936	n	936:936	The number of Mn(VII) per adsorption site (n) was between 0.76 and 0.92 suggested the presence of multi-docking and multi-interactions mechanisms.
34280442	7	30	theme	adsorption	919:928	arg1	site					930:933	adsorption site	919:933	adsorption site (n) was between 0.76 and 0.92	919:963	The number of Mn(VII) per adsorption site (n) was between 0.76 and 0.92 suggested the presence of multi-docking and multi-interactions mechanisms.
34280442	5	31	theme	Mn	688:689	arg1	process					726:732	an endothermic process	711:732	an endothermic process	711:732	Enhancing the Langmuir adsorption capacity from 203.26 to 224.03 mg/g with temperature indicated that Mn(VII) adsorption was an endothermic process.
34280442	5	31	theme	Mn	688:689	arg1	adsorption					696:705	Mn(VII) adsorption	688:705	Mn(VII) adsorption	688:705	Enhancing the Langmuir adsorption capacity from 203.26 to 224.03 mg/g with temperature indicated that Mn(VII) adsorption was an endothermic process.
34280442	2	32	theme	altered	351:357	arg1	temperatures					359:370	altered temperatures	351:370	altered temperatures (i.e., 25, 35, and 45 °C)	351:396	The resulted Cs/Ac was characterized and utilized as a cost-effective adsorbent for Mn(VII) at altered temperatures (i.e., 25, 35, and 45 °C).
34280442	6	33	theme	layer	791:795	arg1	model					797:801	the double layer model	780:801	the double layer model with two energy sites (i.e., the best fit statistical model)	780:862	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	9	34	theme	VII	1139:1141	arg1	uptake					1144:1149	Mn(VII) uptake	1136:1149	Mn(VII) uptake by Cs/Ac	1136:1158	Energetically, Mn(VII) uptake by Cs/Ac was governed by physical interactions (i.e., adsorption energy <40 kJ/mol).
34280442	1	35	theme	multifunctional	197:211	arg1	composite					245:253	a multifunctional chitosan/activated coal (Cs/Ac) composite	195:253	a multifunctional chitosan/activated coal (Cs/Ac) composite	195:253	Chitosan was impregnated into porous activated coal to produce a multifunctional chitosan/activated coal (Cs/Ac) composite.
34280442	11	36	theme	marine	1356:1361	arg1	Cs					1372:1373	Cs	1372:1373	Cs	1372:1373	Overall, modification of the Ac by the used marine biomass (Cs) produced a promising Mn(VII) adsorbent and also, the application of physical analysis offered a deep interpretation for the adsorption mechanism.
34280442	11	36	theme	marine	1356:1361	arg1	biomass					1363:1369	the used marine biomass	1347:1369	the used marine biomass (Cs)	1347:1374	Overall, modification of the Ac by the used marine biomass (Cs) produced a promising Mn(VII) adsorbent and also, the application of physical analysis offered a deep interpretation for the adsorption mechanism.
34280442	5	37	from	203.26	634:639	arg1	capacity					620:627	the Langmuir adsorption capacity	596:627	the Langmuir adsorption capacity from 203.26 to 224.03 mg/g	596:654	Enhancing the Langmuir adsorption capacity from 203.26 to 224.03 mg/g with temperature indicated that Mn(VII) adsorption was an endothermic process.
34280442	0	38	theme	parameters	120:129	arg1	Modeling					73:80	Modeling	73:80	Modeling	73:80	Chitosan/activated coal composite as an effective adsorbent for Mn(VII): Modeling and interpretation of physicochemical parameters.
34280442	0	38	theme	parameters	120:129	arg1	interpretation					86:99	interpretation	86:99	interpretation	86:99	Chitosan/activated coal composite as an effective adsorbent for Mn(VII): Modeling and interpretation of physicochemical parameters.
34280442	11	39	theme	deep	1472:1475	arg1	interpretation					1477:1490	a deep interpretation	1470:1490	a deep interpretation for the adsorption mechanism	1470:1519	Overall, modification of the Ac by the used marine biomass (Cs) produced a promising Mn(VII) adsorbent and also, the application of physical analysis offered a deep interpretation for the adsorption mechanism.
34280442	3	40	theme	adsorption	403:412	arg1	results					414:420	The adsorption results	399:420	The adsorption results	399:420	The adsorption results were fitted to classical as well as advanced statistical physics models.
34280442	6	41	theme	energy	812:817	arg1	sites					819:823	two energy sites	808:823	two energy sites (i.e., the best fit statistical model)	808:862	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	6	41	theme	energy	812:817	arg1	model					857:861	the best fit statistical model	832:861	the best fit statistical model	832:861	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	3	42	theme	classical	437:445	arg1	models					487:492	classical as well as advanced statistical physics models	437:492	classical as well as advanced statistical physics models	437:492	The adsorption results were fitted to classical as well as advanced statistical physics models.
34280442	5	43	theme	VII	691:693	arg1	process					726:732	an endothermic process	711:732	an endothermic process	711:732	Enhancing the Langmuir adsorption capacity from 203.26 to 224.03 mg/g with temperature indicated that Mn(VII) adsorption was an endothermic process.
34280442	5	43	theme	VII	691:693	arg1	adsorption					696:705	Mn(VII) adsorption	688:705	Mn(VII) adsorption	688:705	Enhancing the Langmuir adsorption capacity from 203.26 to 224.03 mg/g with temperature indicated that Mn(VII) adsorption was an endothermic process.
34280442	7	44	theme	multi-interactions	1009:1026	arg1	mechanisms					1028:1037	multi-docking and multi-interactions mechanisms	991:1037	multi-docking and multi-interactions mechanisms	991:1037	The number of Mn(VII) per adsorption site (n) was between 0.76 and 0.92 suggested the presence of multi-docking and multi-interactions mechanisms.
34280442	2	45	used	utilized	297:304	arg2	Cs/Ac					269:273	The resulted Cs/Ac	256:273	The resulted Cs/Ac	256:273	The resulted Cs/Ac was characterized and utilized as a cost-effective adsorbent for Mn(VII) at altered temperatures (i.e., 25, 35, and 45 °C).
34280442	2	45	used	utilized	297:304	arg2	adsorbent					326:334	adsorbent	326:334	adsorbent	326:334	The resulted Cs/Ac was characterized and utilized as a cost-effective adsorbent for Mn(VII) at altered temperatures (i.e., 25, 35, and 45 °C).
34280442	8	46	theme	active	1044:1049	arg1	sites					1051:1055	The active sites density (NM)	1040:1068	The active sites density (NM) of the Cs/Ac	1040:1081	The active sites density (NM) of the Cs/Ac decreased with improving temperature.
34280442	8	46	theme	active	1044:1049	arg1	Cs/Ac					1077:1081	the Cs/Ac	1073:1081	the Cs/Ac	1073:1081	The active sites density (NM) of the Cs/Ac decreased with improving temperature.
34280442	2	47	theme	resulted	260:267	arg1	Cs/Ac					269:273	The resulted Cs/Ac	256:273	The resulted Cs/Ac	256:273	The resulted Cs/Ac was characterized and utilized as a cost-effective adsorbent for Mn(VII) at altered temperatures (i.e., 25, 35, and 45 °C).
34280442	2	47	theme	resulted	260:267	arg1	adsorbent					326:334	adsorbent	326:334	adsorbent	326:334	The resulted Cs/Ac was characterized and utilized as a cost-effective adsorbent for Mn(VII) at altered temperatures (i.e., 25, 35, and 45 °C).
34280442	1	48	theme	coal	232:235	arg1	composite					245:253	a multifunctional chitosan/activated coal (Cs/Ac) composite	195:253	a multifunctional chitosan/activated coal (Cs/Ac) composite	195:253	Chitosan was impregnated into porous activated coal to produce a multifunctional chitosan/activated coal (Cs/Ac) composite.
34280442	6	49	theme	model	797:801	arg1	Steric					735:740	Steric	735:740	Steric	735:740	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	0	50	dep	composite	24:32	arg1	Modeling					73:80	Modeling	73:80	Modeling	73:80	Chitosan/activated coal composite as an effective adsorbent for Mn(VII): Modeling and interpretation of physicochemical parameters.
34280442	0	50	dep	composite	24:32	arg1	interpretation					86:99	interpretation	86:99	interpretation	86:99	Chitosan/activated coal composite as an effective adsorbent for Mn(VII): Modeling and interpretation of physicochemical parameters.
34280442	11	51	theme	analysis	1453:1460	arg1	application					1429:1439	the application	1425:1439	the application of physical analysis	1425:1460	Overall, modification of the Ac by the used marine biomass (Cs) produced a promising Mn(VII) adsorbent and also, the application of physical analysis offered a deep interpretation for the adsorption mechanism.
34280442	7	52	theme	multi-docking	991:1003	arg1	mechanisms					1028:1037	multi-docking and multi-interactions mechanisms	991:1037	multi-docking and multi-interactions mechanisms	991:1037	The number of Mn(VII) per adsorption site (n) was between 0.76 and 0.92 suggested the presence of multi-docking and multi-interactions mechanisms.
34280442	5	53	theme	endothermic	714:724	arg1	process					726:732	an endothermic process	711:732	an endothermic process	711:732	Enhancing the Langmuir adsorption capacity from 203.26 to 224.03 mg/g with temperature indicated that Mn(VII) adsorption was an endothermic process.
34280442	5	53	theme	endothermic	714:724	arg1	adsorption					696:705	Mn(VII) adsorption	688:705	Mn(VII) adsorption	688:705	Enhancing the Langmuir adsorption capacity from 203.26 to 224.03 mg/g with temperature indicated that Mn(VII) adsorption was an endothermic process.
34280442	1	54	theme	chitosan/activated	213:230	arg1	composite					245:253	a multifunctional chitosan/activated coal (Cs/Ac) composite	195:253	a multifunctional chitosan/activated coal (Cs/Ac) composite	195:253	Chitosan was impregnated into porous activated coal to produce a multifunctional chitosan/activated coal (Cs/Ac) composite.
34280442	6	55	with	model	797:801	arg1	sites					819:823	two energy sites	808:823	two energy sites (i.e., the best fit statistical model)	808:862	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	6	55	with	model	797:801	arg1	model					857:861	the best fit statistical model	832:861	the best fit statistical model	832:861	Steric, energetic and thermodynamics data of the double layer model with two energy sites (i.e., the best fit statistical model) were completely interpreted.
34280442	3	56	theme	advanced	458:465	arg1	models					487:492	classical as well as advanced statistical physics models	437:492	classical as well as advanced statistical physics models	437:492	The adsorption results were fitted to classical as well as advanced statistical physics models.
34280442	11	57	theme	used	1351:1354	arg1	Cs					1372:1373	Cs	1372:1373	Cs	1372:1373	Overall, modification of the Ac by the used marine biomass (Cs) produced a promising Mn(VII) adsorbent and also, the application of physical analysis offered a deep interpretation for the adsorption mechanism.
34280442	11	57	theme	used	1351:1354	arg1	biomass					1363:1369	the used marine biomass	1347:1369	the used marine biomass (Cs)	1347:1374	Overall, modification of the Ac by the used marine biomass (Cs) produced a promising Mn(VII) adsorbent and also, the application of physical analysis offered a deep interpretation for the adsorption mechanism.
34280442	1	58	theme	Cs/Ac	238:242	arg1	composite					245:253	a multifunctional chitosan/activated coal (Cs/Ac) composite	195:253	a multifunctional chitosan/activated coal (Cs/Ac) composite	195:253	Chitosan was impregnated into porous activated coal to produce a multifunctional chitosan/activated coal (Cs/Ac) composite.
34280442	3	59	theme	statistical	467:477	arg1	models					487:492	classical as well as advanced statistical physics models	437:492	classical as well as advanced statistical physics models	437:492	The adsorption results were fitted to classical as well as advanced statistical physics models.
32970624	0	0	theme	native	77:82	arg1	chitosan					84:91	native chitosan	77:91	native chitosan	77:91	Hierarchical approach towards adsorptive removal of Alizarin Red S dye using native chitosan and its successively modified versions.
32970624	5	1	theme	42.48	1127:1131	arg1	g-1					1155:1157	42.48, 109.12 and 131.58 mg g-1	1127:1157	g-1	1155:1157	Maximum adsorption capacities towards adsorption of ARS were found to be 42.48, 109.12 and 131.58 mg g-1 for Ch, SCC and SCC-B, respectively.
32970624	2	2	theme	scanning	587:594	arg1	microscopy					605:614	scanning electron microscopy	587:614	scanning electron microscopy	587:614	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	5	3	theme	mg	1152:1153	arg1	g-1					1155:1157	42.48, 109.12 and 131.58 mg g-1	1127:1157	g-1	1155:1157	Maximum adsorption capacities towards adsorption of ARS were found to be 42.48, 109.12 and 131.58 mg g-1 for Ch, SCC and SCC-B, respectively.
32970624	6	4	theme	adsorption	1305:1314	arg1	mechanism					1292:1300	the mechanism	1288:1300	the mechanism of adsorption	1288:1314	Kinetics of adsorption was examined by employing three well-known models in order to deduce the mechanism of adsorption.
32970624	8	5	theme	column	1484:1489	arg1	method					1502:1507	the column adsorption method	1480:1507	the column adsorption method	1480:1507	Furthermore, it was observed that for large sample volumes, the column adsorption method was more effective compared to the batch method.
32970624	8	5	theme	column	1484:1489	arg1	effective					1518:1526	effective	1518:1526	effective	1518:1526	Furthermore, it was observed that for large sample volumes, the column adsorption method was more effective compared to the batch method.
32970624	8	6	theme	sample	1464:1469	arg1	volumes					1471:1477	large sample volumes	1458:1477	large sample volumes	1458:1477	Furthermore, it was observed that for large sample volumes, the column adsorption method was more effective compared to the batch method.
32970624	1	7	theme	anionic	411:417	arg1	S					437:437	Alizarin Red S	424:437	Alizarin Red S (ARS)	424:443	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	7	theme	anionic	411:417	arg1	dye					419:421	an anionic dye	408:421	an anionic dye	408:421	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	3	8	theme	contact	837:843	arg1	time					845:848	contact time	837:848	contact time	837:848	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	2	9	theme	spectroscopy	573:584	arg1	point					750:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point	546:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge	546:769	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	1	10	theme	dye	419:421	arg1	removal					397:403	the removal	393:403	the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions	393:466	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	8	11	theme	batch	1544:1548	arg1	method					1550:1555	the batch method	1540:1555	the batch method	1540:1555	Furthermore, it was observed that for large sample volumes, the column adsorption method was more effective compared to the batch method.
32970624	3	12	theme	initial	867:873	arg1	concentration					885:897	initial adsorbate concentration	867:897	initial adsorbate concentration	867:897	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	3	13	theme	dye	823:825	arg1	solution					827:834	dye solution	823:834	dye solution	823:834	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	5	14	theme	ARS	1106:1108	arg1	adsorption					1092:1101	adsorption	1092:1101	adsorption of ARS	1092:1108	Maximum adsorption capacities towards adsorption of ARS were found to be 42.48, 109.12 and 131.58 mg g-1 for Ch, SCC and SCC-B, respectively.
32970624	2	15	theme	infrared	564:571	arg1	spectroscopy					573:584	Fourier-transform infrared spectroscopy	546:584	Fourier-transform infrared spectroscopy	546:584	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	2	16	theme	X-ray	635:639	arg1	point					750:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point	546:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge	546:769	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	1	17	theme	sulphate	250:257	arg1	SCC					282:284	SCC	282:284	SCC	282:284	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	17	theme	sulphate	250:257	arg1	chitosan					272:279	sulphate cross-linked chitosan	250:279	sulphate cross-linked chitosan (SCC)	250:285	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	17	theme	sulphate	250:257	arg1	versions					233:240	its chemically and physico-chemically modified versions	186:240	its chemically and physico-chemically modified versions	186:240	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	8	18	theme	adsorption	1491:1500	arg1	method					1502:1507	the column adsorption method	1480:1507	the column adsorption method	1480:1507	Furthermore, it was observed that for large sample volumes, the column adsorption method was more effective compared to the batch method.
32970624	8	18	theme	adsorption	1491:1500	arg1	effective					1518:1526	effective	1518:1526	effective	1518:1526	Furthermore, it was observed that for large sample volumes, the column adsorption method was more effective compared to the batch method.
32970624	2	19	theme	energy	617:622	arg1	X-ray					635:639	energy dispersive X-ray	617:639	energy dispersive X-ray	617:639	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	1	20	theme	Alizarin	424:431	arg1	S					437:437	Alizarin Red S	424:437	Alizarin Red S (ARS)	424:443	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	20	theme	Alizarin	424:431	arg1	dye					419:421	an anionic dye	408:421	an anionic dye	408:421	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	20	theme	Alizarin	424:431	arg1	ARS					440:442	ARS	440:442	ARS	440:442	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	2	21	theme	charge	764:769	arg1	point					750:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point	546:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge	546:769	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	1	22	theme	native	154:159	arg1	adsorbents					378:387	potential adsorbents	368:387	potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions	368:466	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	22	theme	native	154:159	arg1	Ch					171:172	Ch	171:172	Ch	171:172	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	22	theme	native	154:159	arg1	chitosan					161:168	native chitosan	154:168	native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B),	154:349	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	3	23	theme	solution	827:834	arg1	pH					817:818	pH	817:818	pH of dye solution	817:834	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	3	23	theme	solution	827:834	arg1	time					845:848	contact time	837:848	contact time	837:848	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	3	23	theme	solution	827:834	arg1	dose					861:864	adsorbent dose	851:864	adsorbent dose	851:864	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	3	23	theme	solution	827:834	arg1	temperature					903:913	temperature	903:913	temperature of adsorption	903:927	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	3	23	theme	solution	827:834	arg1	concentration					885:897	initial adsorbate concentration	867:897	initial adsorbate concentration	867:897	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	1	24	theme	Red	433:435	arg1	S					437:437	Alizarin Red S	424:437	Alizarin Red S (ARS)	424:443	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	24	theme	Red	433:435	arg1	dye					419:421	an anionic dye	408:421	an anionic dye	408:421	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	24	theme	Red	433:435	arg1	ARS					440:442	ARS	440:442	ARS	440:442	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	3	25	theme	Various	772:778	arg1	parameters					780:789	Various parameters	772:789	Various parameters	772:789	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	2	26	theme	microscopy	605:614	arg1	point					750:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point	546:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge	546:769	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	2	27	theme	Brunauer-Emmett-Teller	661:682	arg1	analysis					684:691	Brunauer-Emmett-Teller analysis	661:691	Brunauer-Emmett-Teller analysis	661:691	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	0	28	theme	Hierarchical	0:11	arg1	approach					13:20	Hierarchical approach	0:20	Hierarchical approach towards adsorptive removal of Alizarin Red S dye	0:69	Hierarchical approach towards adsorptive removal of Alizarin Red S dye using native chitosan and its successively modified versions.
32970624	1	29	theme	cross-linked	259:270	arg1	SCC					282:284	SCC	282:284	SCC	282:284	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	29	theme	cross-linked	259:270	arg1	chitosan					272:279	sulphate cross-linked chitosan	250:279	sulphate cross-linked chitosan (SCC)	250:285	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	29	theme	cross-linked	259:270	arg1	versions					233:240	its chemically and physico-chemically modified versions	186:240	its chemically and physico-chemically modified versions	186:240	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	2	30	theme	electron	596:603	arg1	microscopy					605:614	scanning electron microscopy	587:614	scanning electron microscopy	587:614	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	2	31	theme	thermal	725:731	arg1	analysis					733:740	thermogravimetric-differential thermal analysis	694:740	thermogravimetric-differential thermal analysis	694:740	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	0	32	theme	adsorptive	30:39	arg1	removal					41:47	adsorptive removal	30:47	adsorptive removal of Alizarin Red S dye	30:69	Hierarchical approach towards adsorptive removal of Alizarin Red S dye using native chitosan and its successively modified versions.
32970624	2	33	theme	diffraction	648:658	arg1	point					750:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point	546:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge	546:769	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	2	34	theme	dispersive	624:633	arg1	X-ray					635:639	energy dispersive X-ray	617:639	energy dispersive X-ray	617:639	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	2	35	theme	X-ray	642:646	arg1	diffraction					648:658	X-ray diffraction	642:658	X-ray diffraction	642:658	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	0	36	theme	modified	114:121	arg1	versions					123:130	its successively modified versions	97:130	its successively modified versions	97:130	Hierarchical approach towards adsorptive removal of Alizarin Red S dye using native chitosan and its successively modified versions.
32970624	8	37	theme	large	1458:1462	arg1	volumes					1471:1477	large sample volumes	1458:1477	large sample volumes	1458:1477	Furthermore, it was observed that for large sample volumes, the column adsorption method was more effective compared to the batch method.
32970624	1	38	from	solutions	458:466	arg1	removal					397:403	the removal	393:403	the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions	393:466	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	4	39	theme	Freundlich	1001:1010	arg1	model					1012:1016	the Freundlich model	997:1016	the Freundlich model	997:1016	Four adsorption isotherm models were studied and it was found that the Freundlich model was best-fit for all three systems.
32970624	4	39	theme	Freundlich	1001:1010	arg1	best-fit					1022:1029	best-fit	1022:1029	best-fit	1022:1029	Four adsorption isotherm models were studied and it was found that the Freundlich model was best-fit for all three systems.
32970624	3	40	theme	adsorption	918:927	arg1	pH					817:818	pH	817:818	pH of dye solution	817:834	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	3	40	theme	adsorption	918:927	arg1	time					845:848	contact time	837:848	contact time	837:848	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	3	40	theme	adsorption	918:927	arg1	dose					861:864	adsorbent dose	851:864	adsorbent dose	851:864	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	3	40	theme	adsorption	918:927	arg1	temperature					903:913	temperature	903:913	temperature of adsorption	903:927	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	3	40	theme	adsorption	918:927	arg1	concentration					885:897	initial adsorbate concentration	867:897	initial adsorbate concentration	867:897	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	4	41	theme	isotherm	946:953	arg1	models					955:960	Four adsorption isotherm models	930:960	Four adsorption isotherm models	930:960	Four adsorption isotherm models were studied and it was found that the Freundlich model was best-fit for all three systems.
32970624	1	42	theme	potential	368:376	arg1	adsorbents					378:387	potential adsorbents	368:387	potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions	368:466	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	42	theme	potential	368:376	arg1	chitosan					161:168	native chitosan	154:168	native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B),	154:349	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	6	43	theme	adsorption	1208:1217	arg1	Kinetics					1196:1203	Kinetics	1196:1203	Kinetics of adsorption	1196:1217	Kinetics of adsorption was examined by employing three well-known models in order to deduce the mechanism of adsorption.
32970624	4	44	theme	adsorption	935:944	arg1	models					955:960	Four adsorption isotherm models	930:960	Four adsorption isotherm models	930:960	Four adsorption isotherm models were studied and it was found that the Freundlich model was best-fit for all three systems.
32970624	2	45	theme	thermogravimetric-differential	694:723	arg1	analysis					733:740	thermogravimetric-differential thermal analysis	694:740	thermogravimetric-differential thermal analysis	694:740	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	2	46	theme	analysis	733:740	arg1	point					750:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point	546:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge	546:769	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	0	47	theme	Red	61:63	arg1	dye					67:69	Alizarin Red S dye	52:69	Alizarin Red S dye	52:69	Hierarchical approach towards adsorptive removal of Alizarin Red S dye using native chitosan and its successively modified versions.
32970624	5	48	theme	131.58	1145:1150	arg1	g-1					1155:1157	42.48, 109.12 and 131.58 mg g-1	1127:1157	g-1	1155:1157	Maximum adsorption capacities towards adsorption of ARS were found to be 42.48, 109.12 and 131.58 mg g-1 for Ch, SCC and SCC-B, respectively.
32970624	2	49	theme	Fourier-transform	546:562	arg1	spectroscopy					573:584	Fourier-transform infrared spectroscopy	546:584	Fourier-transform infrared spectroscopy	546:584	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	1	50	link	cross-linked	300:311	arg1	SCC-B					343:347	SCC-B	343:347	SCC-B	343:347	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	50	link	cross-linked	300:311	arg1	composite					332:340	sulphate cross-linked chitosan-bentonite composite	291:340	sulphate cross-linked chitosan-bentonite composite (SCC-B)	291:348	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	50	link	cross-linked	300:311	arg1	versions					233:240	its chemically and physico-chemically modified versions	186:240	its chemically and physico-chemically modified versions	186:240	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	0	51	theme	Alizarin	52:59	arg1	dye					67:69	Alizarin Red S dye	52:69	Alizarin Red S dye	52:69	Hierarchical approach towards adsorptive removal of Alizarin Red S dye using native chitosan and its successively modified versions.
32970624	1	52	theme	sulphate	291:298	arg1	SCC-B					343:347	SCC-B	343:347	SCC-B	343:347	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	52	theme	sulphate	291:298	arg1	composite					332:340	sulphate cross-linked chitosan-bentonite composite	291:340	sulphate cross-linked chitosan-bentonite composite (SCC-B)	291:348	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	52	theme	sulphate	291:298	arg1	versions					233:240	its chemically and physico-chemically modified versions	186:240	its chemically and physico-chemically modified versions	186:240	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	53	theme	aqueous	450:456	arg1	solutions					458:466	aqueous solutions	450:466	aqueous solutions	450:466	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	6	54	theme	well-known	1251:1260	arg1	models					1262:1267	three well-known models	1245:1267	three well-known models in order to deduce the mechanism of adsorption	1245:1314	Kinetics of adsorption was examined by employing three well-known models in order to deduce the mechanism of adsorption.
32970624	3	55	theme	adsorbent	851:859	arg1	dose					861:864	adsorbent dose	851:864	adsorbent dose	851:864	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	1	56	theme	cross-linked	300:311	arg1	SCC-B					343:347	SCC-B	343:347	SCC-B	343:347	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	56	theme	cross-linked	300:311	arg1	composite					332:340	sulphate cross-linked chitosan-bentonite composite	291:340	sulphate cross-linked chitosan-bentonite composite (SCC-B)	291:348	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	56	theme	cross-linked	300:311	arg1	versions					233:240	its chemically and physico-chemically modified versions	186:240	its chemically and physico-chemically modified versions	186:240	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	2	57	theme	analysis	684:691	arg1	point					750:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point	546:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge	546:769	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	1	58	theme	chemically	190:199	arg1	chitosan					272:279	sulphate cross-linked chitosan	250:279	sulphate cross-linked chitosan (SCC)	250:285	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	58	theme	chemically	190:199	arg1	versions					233:240	its chemically and physico-chemically modified versions	186:240	its chemically and physico-chemically modified versions	186:240	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	58	theme	chemically	190:199	arg1	composite					332:340	sulphate cross-linked chitosan-bentonite composite	291:340	sulphate cross-linked chitosan-bentonite composite (SCC-B)	291:348	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	5	59	theme	Maximum	1054:1060	arg1	capacities					1073:1082	Maximum adsorption capacities	1054:1082	Maximum adsorption capacities towards adsorption of ARS	1054:1108	Maximum adsorption capacities towards adsorption of ARS were found to be 42.48, 109.12 and 131.58 mg g-1 for Ch, SCC and SCC-B, respectively.
32970624	0	60	theme	dye	67:69	arg1	removal					41:47	adsorptive removal	30:47	adsorptive removal of Alizarin Red S dye	30:69	Hierarchical approach towards adsorptive removal of Alizarin Red S dye using native chitosan and its successively modified versions.
32970624	5	61	theme	adsorption	1062:1071	arg1	capacities					1073:1082	Maximum adsorption capacities	1054:1082	Maximum adsorption capacities towards adsorption of ARS	1054:1108	Maximum adsorption capacities towards adsorption of ARS were found to be 42.48, 109.12 and 131.58 mg g-1 for Ch, SCC and SCC-B, respectively.
32970624	7	62	theme	Thermodynamic	1317:1329	arg1	studies					1331:1337	Thermodynamic studies	1317:1337	Thermodynamic studies	1317:1337	Thermodynamic studies show that the process is spontaneous and exothermic for all adsorbents employed.
32970624	2	63	theme	pH	747:748	arg1	point					750:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point	546:754	Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge	546:769	All three adsorbents were extensively characterized using techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, Brunauer-Emmett-Teller analysis, thermogravimetric-differential thermal analysis, and pH point of zero charge.
32970624	1	64	theme	physico-chemically	205:222	arg1	chitosan					272:279	sulphate cross-linked chitosan	250:279	sulphate cross-linked chitosan (SCC)	250:285	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	64	theme	physico-chemically	205:222	arg1	versions					233:240	its chemically and physico-chemically modified versions	186:240	its chemically and physico-chemically modified versions	186:240	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	64	theme	physico-chemically	205:222	arg1	composite					332:340	sulphate cross-linked chitosan-bentonite composite	291:340	sulphate cross-linked chitosan-bentonite composite (SCC-B)	291:348	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	0	65	theme	S	65:65	arg1	dye					67:69	Alizarin Red S dye	52:69	Alizarin Red S dye	52:69	Hierarchical approach towards adsorptive removal of Alizarin Red S dye using native chitosan and its successively modified versions.
32970624	1	66	theme	chitosan-bentonite	313:330	arg1	SCC-B					343:347	SCC-B	343:347	SCC-B	343:347	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	66	theme	chitosan-bentonite	313:330	arg1	composite					332:340	sulphate cross-linked chitosan-bentonite composite	291:340	sulphate cross-linked chitosan-bentonite composite (SCC-B)	291:348	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	66	theme	chitosan-bentonite	313:330	arg1	versions					233:240	its chemically and physico-chemically modified versions	186:240	its chemically and physico-chemically modified versions	186:240	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	67	link	cross-linked	259:270	arg1	SCC					282:284	SCC	282:284	SCC	282:284	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	67	link	cross-linked	259:270	arg1	chitosan					272:279	sulphate cross-linked chitosan	250:279	sulphate cross-linked chitosan (SCC)	250:285	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	67	link	cross-linked	259:270	arg1	versions					233:240	its chemically and physico-chemically modified versions	186:240	its chemically and physico-chemically modified versions	186:240	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	68	theme	present	140:146	arg1	work					148:151	the present work	136:151	the present work	136:151	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	3	69	theme	adsorbate	875:883	arg1	concentration					885:897	initial adsorbate concentration	867:897	initial adsorbate concentration	867:897	Various parameters were optimized, including pH of dye solution, contact time, adsorbent dose, initial adsorbate concentration and temperature of adsorption.
32970624	1	70	theme	modified	224:231	arg1	chitosan					272:279	sulphate cross-linked chitosan	250:279	sulphate cross-linked chitosan (SCC)	250:285	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	70	theme	modified	224:231	arg1	versions					233:240	its chemically and physico-chemically modified versions	186:240	its chemically and physico-chemically modified versions	186:240	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
32970624	1	70	theme	modified	224:231	arg1	composite					332:340	sulphate cross-linked chitosan-bentonite composite	291:340	sulphate cross-linked chitosan-bentonite composite (SCC-B)	291:348	In the present work, native chitosan (Ch) along with its chemically and physico-chemically modified versions, namely sulphate cross-linked chitosan (SCC) and sulphate cross-linked chitosan-bentonite composite (SCC-B), were employed as potential adsorbents for the removal of an anionic dye, Alizarin Red S (ARS) from aqueous solutions.
33399124	0	0	theme	tissue	90:95	arg1	activator					109:117	tissue plasminogen activator	90:117	tissue plasminogen activator delivery	90:126	Investigation of chitosan-g-PEG grafted nanoparticles as a half-life enhancer carrier for tissue plasminogen activator delivery.
33399124	9	1	theme	burst	1007:1011	arg1	effect					1013:1018	a burst effect	1005:1018	a burst effect	1005:1018	Release study revealed that a burst effect happened in the first 5 min and resulted in releasing 30% of tPA.
33399124	10	2	theme	activity	1131:1138	arg1	%					1122:1122	25%	1120:1122	25% of its activity	1120:1138	Loading tPA in NPs could decrease 25% of its activity but the half-life of it increases in comparison to free tPA in vivo.
33399124	10	2	theme	activity	1131:1138	arg1	activity					1131:1138	its activity	1127:1138	its activity	1127:1138	Loading tPA in NPs could decrease 25% of its activity but the half-life of it increases in comparison to free tPA in vivo.
33399124	12	3	theme	enzyme	1362:1367	arg1	half-life					1369:1377	enzyme half-life	1362:1377	enzyme half-life	1362:1377	So, CS-g-PEG/tPA could increase enzyme half-life during the time and could be used as a non-toxic candidate delivery system for tPA.
33399124	7	4	dep	in	851:852	arg1	vivo					854:857	vivo	854:857	vivo	854:857	Then, NPs cytotoxicity, release profile, enzyme activity and in vivo half-life and coagulation time were investigated.
33399124	1	5	theme	thrombolytic	166:177	arg1	agent					179:183	a thrombolytic agent	164:183	Tissue plasminogen activator (tPA) a thrombolytic agent	129:183	Tissue plasminogen activator (tPA) a thrombolytic agent is commonly used for digesting the blood clot.
33399124	0	6	theme	activator	109:117	arg1	delivery					119:126	tissue plasminogen activator delivery	90:126	tissue plasminogen activator delivery	90:126	Investigation of chitosan-g-PEG grafted nanoparticles as a half-life enhancer carrier for tissue plasminogen activator delivery.
33399124	6	7	theme	composite	772:780	arg1	design					782:787	central composite design	764:787	central composite design	764:787	Particles' size and loading capacity were optimised by central composite design.
33399124	1	8	dep	activator	148:156	arg1	agent					179:183	a thrombolytic agent	164:183	Tissue plasminogen activator (tPA) a thrombolytic agent	129:183	Tissue plasminogen activator (tPA) a thrombolytic agent is commonly used for digesting the blood clot.
33399124	7	9	theme	enzyme	831:836	arg1	activity					838:845	enzyme activity	831:845	enzyme activity	831:845	Then, NPs cytotoxicity, release profile, enzyme activity and in vivo half-life and coagulation time were investigated.
33399124	12	10	theme	candidate	1428:1436	arg1	system					1447:1452	a non-toxic candidate delivery system	1416:1452	a non-toxic candidate delivery system for tPA	1416:1460	So, CS-g-PEG/tPA could increase enzyme half-life during the time and could be used as a non-toxic candidate delivery system for tPA.
33399124	12	10	theme	candidate	1428:1436	arg1	CS-g-PEG/tPA					1334:1345	CS-g-PEG/tPA	1334:1345	CS-g-PEG/tPA	1334:1345	So, CS-g-PEG/tPA could increase enzyme half-life during the time and could be used as a non-toxic candidate delivery system for tPA.
33399124	3	11	theme	enzyme	362:367	arg1	dosage					369:374	enzyme dosage	362:374	enzyme dosage	362:374	Improving tPA half-life could reduce enzyme dosage and enhance patient compliance.
33399124	4	12	theme	enzymes	477:483	arg1	protection					463:472	the protection	459:472	the protection of enzymes physically, enhancing half-life and increasing the stability of them	459:552	Nano-carries could be used as delivery systems for the protection of enzymes physically, enhancing half-life and increasing the stability of them.
33399124	5	13	theme	polyethylene	588:599	arg1	PEG					609:611	PEG	609:611	PEG	609:611	In this study, chitosan (CS) and polyethylene glycol (PEG) were used for the preparation of CS-g-PEG/tPA nanoparticles (NPs) via the ion gelation method.
33399124	5	13	theme	polyethylene	588:599	arg1	glycol					601:606	polyethylene glycol	588:606	polyethylene glycol (PEG)	588:612	In this study, chitosan (CS) and polyethylene glycol (PEG) were used for the preparation of CS-g-PEG/tPA nanoparticles (NPs) via the ion gelation method.
33399124	7	14	theme	release	814:820	arg1	profile					822:828	release profile	814:828	release profile	814:828	Then, NPs cytotoxicity, release profile, enzyme activity and in vivo half-life and coagulation time were investigated.
33399124	12	15	theme	non-toxic	1418:1426	arg1	system					1447:1452	a non-toxic candidate delivery system	1416:1452	a non-toxic candidate delivery system for tPA	1416:1460	So, CS-g-PEG/tPA could increase enzyme half-life during the time and could be used as a non-toxic candidate delivery system for tPA.
33399124	12	15	theme	non-toxic	1418:1426	arg1	CS-g-PEG/tPA					1334:1345	CS-g-PEG/tPA	1334:1345	CS-g-PEG/tPA	1334:1345	So, CS-g-PEG/tPA could increase enzyme half-life during the time and could be used as a non-toxic candidate delivery system for tPA.
33399124	11	16	theme	free	1320:1323	arg1	tPA					1325:1327	free tPA	1320:1327	free tPA	1320:1327	Also, blood coagulation time has significantly affected (p-value = 0.041) by encapsulated tPA in comparison to free tPA.
33399124	2	17	dep	low	249:251	arg1	4-6 min					254:260	4-6 min	254:260	4-6 min	254:260	tPA half-life is low (4-6 min) and its administration needs a prolonged continuous infusion.
33399124	4	18	used	used	430:433	arg2	Nano-carries					408:419	Nano-carries	408:419	Nano-carries	408:419	Nano-carries could be used as delivery systems for the protection of enzymes physically, enhancing half-life and increasing the stability of them.
33399124	4	18	used	used	430:433	arg2	systems					447:453	delivery systems	438:453	delivery systems for the protection of enzymes physically, enhancing half-life and increasing the stability of them	438:552	Nano-carries could be used as delivery systems for the protection of enzymes physically, enhancing half-life and increasing the stability of them.
33399124	11	19	dep	affected	1256:1263	arg1	p-value = 0.041					1266:1280	p-value = 0.041	1266:1280	p-value = 0.041	1266:1280	Also, blood coagulation time has significantly affected (p-value = 0.041) by encapsulated tPA in comparison to free tPA.
33399124	8	20	theme	significant	951:961	arg1	cytotoxicity					963:974	significant cytotoxicity	951:974	significant cytotoxicity	951:974	The results showed that NPs does not have significant cytotoxicity.
33399124	12	21	theme	delivery	1438:1445	arg1	system					1447:1452	a non-toxic candidate delivery system	1416:1452	a non-toxic candidate delivery system for tPA	1416:1460	So, CS-g-PEG/tPA could increase enzyme half-life during the time and could be used as a non-toxic candidate delivery system for tPA.
33399124	12	21	theme	delivery	1438:1445	arg1	CS-g-PEG/tPA					1334:1345	CS-g-PEG/tPA	1334:1345	CS-g-PEG/tPA	1334:1345	So, CS-g-PEG/tPA could increase enzyme half-life during the time and could be used as a non-toxic candidate delivery system for tPA.
33399124	9	22	theme	first	1036:1040	arg1	5 min					1042:1046	the first 5 min	1032:1046	the first 5 min	1032:1046	Release study revealed that a burst effect happened in the first 5 min and resulted in releasing 30% of tPA.
33399124	10	23	theme	Loading	1086:1092	arg1	tPA					1094:1096	Loading tPA	1086:1096	Loading tPA in NPs	1086:1103	Loading tPA in NPs could decrease 25% of its activity but the half-life of it increases in comparison to free tPA in vivo.
33399124	2	24	theme	continuous	304:313	arg1	infusion					315:322	a prolonged continuous infusion	292:322	a prolonged continuous infusion	292:322	tPA half-life is low (4-6 min) and its administration needs a prolonged continuous infusion.
33399124	3	25	theme	patient	388:394	arg1	compliance					396:405	patient compliance	388:405	patient compliance	388:405	Improving tPA half-life could reduce enzyme dosage and enhance patient compliance.
33399124	10	26	from	tPA	1094:1096	arg1	NPs					1101:1103	NPs	1101:1103	NPs	1101:1103	Loading tPA in NPs could decrease 25% of its activity but the half-life of it increases in comparison to free tPA in vivo.
33399124	7	27	theme	coagulation	873:883	arg1	time					885:888	in vivo half-life and coagulation time	851:888	time	885:888	Then, NPs cytotoxicity, release profile, enzyme activity and in vivo half-life and coagulation time were investigated.
33399124	2	28	theme	prolonged	294:302	arg1	infusion					315:322	a prolonged continuous infusion	292:322	a prolonged continuous infusion	292:322	tPA half-life is low (4-6 min) and its administration needs a prolonged continuous infusion.
33399124	11	29	theme	blood	1215:1219	arg1	time					1233:1236	blood coagulation time	1215:1236	blood coagulation time	1215:1236	Also, blood coagulation time has significantly affected (p-value = 0.041) by encapsulated tPA in comparison to free tPA.
33399124	12	30	used	used	1408:1411	arg2	system					1447:1452	a non-toxic candidate delivery system	1416:1452	a non-toxic candidate delivery system for tPA	1416:1460	So, CS-g-PEG/tPA could increase enzyme half-life during the time and could be used as a non-toxic candidate delivery system for tPA.
33399124	12	30	used	used	1408:1411	arg2	CS-g-PEG/tPA					1334:1345	CS-g-PEG/tPA	1334:1345	CS-g-PEG/tPA	1334:1345	So, CS-g-PEG/tPA could increase enzyme half-life during the time and could be used as a non-toxic candidate delivery system for tPA.
33399124	6	31	theme	loading	729:735	arg1	capacity					737:744	loading capacity	729:744	loading capacity	729:744	Particles' size and loading capacity were optimised by central composite design.
33399124	7	32	theme	NPs	796:798	arg1	cytotoxicity					800:811	NPs cytotoxicity	796:811	NPs cytotoxicity	796:811	Then, NPs cytotoxicity, release profile, enzyme activity and in vivo half-life and coagulation time were investigated.
33399124	0	33	theme	chitosan-g-PEG	17:30	arg1	Investigation					0:12	Investigation	0:12	Investigation of chitosan-g-PEG grafted	0:38	Investigation of chitosan-g-PEG grafted nanoparticles as a half-life enhancer carrier for tissue plasminogen activator delivery.
33399124	4	34	dep	enzymes	477:483	arg1	enhancing					497:505	enhancing	497:505	enhancing half-life	497:515	Nano-carries could be used as delivery systems for the protection of enzymes physically, enhancing half-life and increasing the stability of them.
33399124	4	34	dep	enzymes	477:483	arg1	increasing					521:530	increasing	521:530	increasing the stability of them	521:552	Nano-carries could be used as delivery systems for the protection of enzymes physically, enhancing half-life and increasing the stability of them.
33399124	5	35	theme	gelation	692:699	arg1	method					701:706	the ion gelation method	684:706	the ion gelation method	684:706	In this study, chitosan (CS) and polyethylene glycol (PEG) were used for the preparation of CS-g-PEG/tPA nanoparticles (NPs) via the ion gelation method.
33399124	2	36	theme	tPA	232:234	arg1	half-life					236:244	tPA half-life	232:244	tPA half-life	232:244	tPA half-life is low (4-6 min) and its administration needs a prolonged continuous infusion.
33399124	1	37	theme	blood	220:224	arg1	clot					226:229	the blood clot	216:229	the blood clot	216:229	Tissue plasminogen activator (tPA) a thrombolytic agent is commonly used for digesting the blood clot.
33399124	0	38	theme	half-life	59:67	arg1	carrier					78:84	a half-life enhancer carrier	57:84	a half-life enhancer carrier for tissue plasminogen activator delivery	57:126	Investigation of chitosan-g-PEG grafted nanoparticles as a half-life enhancer carrier for tissue plasminogen activator delivery.
33399124	5	39	theme	ion	688:690	arg1	method					701:706	the ion gelation method	684:706	the ion gelation method	684:706	In this study, chitosan (CS) and polyethylene glycol (PEG) were used for the preparation of CS-g-PEG/tPA nanoparticles (NPs) via the ion gelation method.
33399124	6	40	theme	central	764:770	arg1	design					782:787	central composite design	764:787	central composite design	764:787	Particles' size and loading capacity were optimised by central composite design.
33399124	0	41	theme	enhancer	69:76	arg1	carrier					78:84	a half-life enhancer carrier	57:84	a half-life enhancer carrier for tissue plasminogen activator delivery	57:126	Investigation of chitosan-g-PEG grafted nanoparticles as a half-life enhancer carrier for tissue plasminogen activator delivery.
33399124	1	42	theme	Tissue	129:134	arg1	activator					148:156	Tissue plasminogen activator	129:156	Tissue plasminogen activator (tPA) a thrombolytic agent	129:183	Tissue plasminogen activator (tPA) a thrombolytic agent is commonly used for digesting the blood clot.
33399124	1	42	theme	Tissue	129:134	arg1	tPA					159:161	tPA	159:161	tPA	159:161	Tissue plasminogen activator (tPA) a thrombolytic agent is commonly used for digesting the blood clot.
33399124	4	43	theme	them	549:552	arg1	stability					536:544	the stability	532:544	the stability of them	532:552	Nano-carries could be used as delivery systems for the protection of enzymes physically, enhancing half-life and increasing the stability of them.
33399124	5	44	theme	CS-g-PEG/tPA	647:658	arg1	nanoparticles					660:672	CS-g-PEG/tPA nanoparticles	647:672	CS-g-PEG/tPA nanoparticles (NPs)	647:678	In this study, chitosan (CS) and polyethylene glycol (PEG) were used for the preparation of CS-g-PEG/tPA nanoparticles (NPs) via the ion gelation method.
33399124	5	44	theme	CS-g-PEG/tPA	647:658	arg1	NPs					675:677	NPs	675:677	NPs	675:677	In this study, chitosan (CS) and polyethylene glycol (PEG) were used for the preparation of CS-g-PEG/tPA nanoparticles (NPs) via the ion gelation method.
33399124	1	45	theme	plasminogen	136:146	arg1	activator					148:156	Tissue plasminogen activator	129:156	Tissue plasminogen activator (tPA) a thrombolytic agent	129:183	Tissue plasminogen activator (tPA) a thrombolytic agent is commonly used for digesting the blood clot.
33399124	1	45	theme	plasminogen	136:146	arg1	tPA					159:161	tPA	159:161	tPA	159:161	Tissue plasminogen activator (tPA) a thrombolytic agent is commonly used for digesting the blood clot.
33399124	9	46	theme	Release	977:983	arg1	study					985:989	Release study	977:989	Release study	977:989	Release study revealed that a burst effect happened in the first 5 min and resulted in releasing 30% of tPA.
33399124	5	47	theme	nanoparticles	660:672	arg1	preparation					632:642	the preparation	628:642	the preparation of CS-g-PEG/tPA nanoparticles (NPs)	628:678	In this study, chitosan (CS) and polyethylene glycol (PEG) were used for the preparation of CS-g-PEG/tPA nanoparticles (NPs) via the ion gelation method.
33399124	1	48	used	used	197:200	arg2	tPA					159:161	tPA	159:161	tPA	159:161	Tissue plasminogen activator (tPA) a thrombolytic agent is commonly used for digesting the blood clot.
33399124	1	48	used	used	197:200	arg2	activator					148:156	Tissue plasminogen activator	129:156	Tissue plasminogen activator (tPA) a thrombolytic agent	129:183	Tissue plasminogen activator (tPA) a thrombolytic agent is commonly used for digesting the blood clot.
33399124	9	49	theme	tPA	1081:1083	arg1	tPA					1081:1083	tPA	1081:1083	tPA	1081:1083	Release study revealed that a burst effect happened in the first 5 min and resulted in releasing 30% of tPA.
33399124	9	49	theme	tPA	1081:1083	arg1	%					1076:1076	30%	1074:1076	30% of tPA	1074:1083	Release study revealed that a burst effect happened in the first 5 min and resulted in releasing 30% of tPA.
33399124	5	50	used	used	619:622	arg2	glycol					601:606	polyethylene glycol	588:606	polyethylene glycol (PEG)	588:612	In this study, chitosan (CS) and polyethylene glycol (PEG) were used for the preparation of CS-g-PEG/tPA nanoparticles (NPs) via the ion gelation method.
33399124	5	50	used	used	619:622	arg2	CS					580:581	CS	580:581	CS	580:581	In this study, chitosan (CS) and polyethylene glycol (PEG) were used for the preparation of CS-g-PEG/tPA nanoparticles (NPs) via the ion gelation method.
33399124	5	50	used	used	619:622	arg2	PEG					609:611	PEG	609:611	PEG	609:611	In this study, chitosan (CS) and polyethylene glycol (PEG) were used for the preparation of CS-g-PEG/tPA nanoparticles (NPs) via the ion gelation method.
33399124	5	50	used	used	619:622	arg2	chitosan					570:577	chitosan	570:577	chitosan (CS)	570:582	In this study, chitosan (CS) and polyethylene glycol (PEG) were used for the preparation of CS-g-PEG/tPA nanoparticles (NPs) via the ion gelation method.
33399124	11	51	from	tPA	1299:1301	arg1	comparison					1306:1315	comparison	1306:1315	comparison to free tPA	1306:1327	Also, blood coagulation time has significantly affected (p-value = 0.041) by encapsulated tPA in comparison to free tPA.
33399124	4	52	theme	delivery	438:445	arg1	Nano-carries					408:419	Nano-carries	408:419	Nano-carries	408:419	Nano-carries could be used as delivery systems for the protection of enzymes physically, enhancing half-life and increasing the stability of them.
33399124	4	52	theme	delivery	438:445	arg1	systems					447:453	delivery systems	438:453	delivery systems for the protection of enzymes physically, enhancing half-life and increasing the stability of them	438:552	Nano-carries could be used as delivery systems for the protection of enzymes physically, enhancing half-life and increasing the stability of them.
33399124	7	53	theme	in	851:852	arg1	half-life					859:867	in vivo half-life and coagulation time	851:888	half-life	859:867	Then, NPs cytotoxicity, release profile, enzyme activity and in vivo half-life and coagulation time were investigated.
33399124	10	54	theme	free	1191:1194	arg1	tPA					1196:1198	free tPA	1191:1198	free tPA	1191:1198	Loading tPA in NPs could decrease 25% of its activity but the half-life of it increases in comparison to free tPA in vivo.
33399124	11	55	theme	encapsulated	1286:1297	arg1	tPA					1299:1301	encapsulated tPA	1286:1301	encapsulated tPA in comparison to free tPA	1286:1327	Also, blood coagulation time has significantly affected (p-value = 0.041) by encapsulated tPA in comparison to free tPA.
33399124	10	56	theme	it	1161:1162	arg1	half-life					1148:1156	the half-life	1144:1156	the half-life of it	1144:1162	Loading tPA in NPs could decrease 25% of its activity but the half-life of it increases in comparison to free tPA in vivo.
33399124	8	57	contain	have	946:949	arg2	cytotoxicity					963:974	significant cytotoxicity	951:974	significant cytotoxicity	951:974	The results showed that NPs does not have significant cytotoxicity.
33399124	8	57	contain	have	946:949	arg1	NPs					933:935	NPs	933:935	NPs	933:935	The results showed that NPs does not have significant cytotoxicity.
33399124	3	58	theme	tPA	335:337	arg1	half-life					339:347	tPA half-life	335:347	tPA half-life	335:347	Improving tPA half-life could reduce enzyme dosage and enhance patient compliance.
33399124	11	59	theme	coagulation	1221:1231	arg1	time					1233:1236	blood coagulation time	1215:1236	blood coagulation time	1215:1236	Also, blood coagulation time has significantly affected (p-value = 0.041) by encapsulated tPA in comparison to free tPA.
33399124	0	60	theme	plasminogen	97:107	arg1	activator					109:117	tissue plasminogen activator	90:117	tissue plasminogen activator delivery	90:126	Investigation of chitosan-g-PEG grafted nanoparticles as a half-life enhancer carrier for tissue plasminogen activator delivery.
32853615	12	0	theme	individual	1999:2008	arg1	influence					2010:2018	their individual influence	1993:2018	their individual influence on the same cells	1993:2036	The filler type and/or dopant type possess no remarkable influence on the cytotoxicity of the membranes against the investigated cells when compared to their individual influence on the same cells.
32853615	4	1	used	used	769:772	arg2	MC					760:761	MC	760:761	MC	760:761	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	4	1	used	used	769:772	arg2	cellulose					749:757	sodium alginate (Alg)/methyl cellulose	720:757	sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique	720:861	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	9	2	theme	FTIR	1394:1397	arg1	data					1407:1410	The XRD, FTIR and SEM data	1385:1410	The XRD, FTIR and SEM data	1385:1410	The XRD, FTIR and SEM data recognised the possible interaction that takes place among Alg and MC, through presence of hydrogen bonds.
32853615	12	3	theme	investigated	1957:1968	arg1	cells					1970:1974	the investigated cells	1953:1974	the investigated cells	1953:1974	The filler type and/or dopant type possess no remarkable influence on the cytotoxicity of the membranes against the investigated cells when compared to their individual influence on the same cells.
32853615	10	4	theme	nano-particles	1536:1549	arg1	Existence					1519:1527	Existence	1519:1527	Existence of the nano-particles within the membrane polymer matrix	1519:1584	Existence of the nano-particles within the membrane polymer matrix enhanced the membrane stability and enhanced the drug release rate (from 20 to 45%).
32853615	9	5	theme	SEM	1403:1405	arg1	data					1407:1410	The XRD, FTIR and SEM data	1385:1410	The XRD, FTIR and SEM data	1385:1410	The XRD, FTIR and SEM data recognised the possible interaction that takes place among Alg and MC, through presence of hydrogen bonds.
32853615	4	6	theme	sodium	720:725	arg1	MC					760:761	MC	760:761	MC	760:761	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	4	6	theme	sodium	720:725	arg1	cellulose					749:757	sodium alginate (Alg)/methyl cellulose	720:757	sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique	720:861	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	13	7	from	effect	2093:2098	arg1	cells					2132:2136	the cells affinity and growth	2128:2156	the cells affinity and growth	2128:2156	Cells attachments results have revealed an impressive effect for DOX-loaded membranes on the cells affinity and growth.
32853615	13	7	from	effect	2093:2098	arg1	growth					2151:2156	growth	2151:2156	growth	2151:2156	Cells attachments results have revealed an impressive effect for DOX-loaded membranes on the cells affinity and growth.
32853615	13	7	from	effect	2093:2098	arg1	affinity					2138:2145	affinity	2138:2145	affinity	2138:2145	Cells attachments results have revealed an impressive effect for DOX-loaded membranes on the cells affinity and growth.
32853615	7	8	theme	released	1161:1168	arg1	drug					1170:1173	the released drug	1157:1173	the released drug	1157:1173	Profiles of the released drug were determined using phosphate-buffered saline (PBS) (pH 7.4) at 37 °C for 30 days.
32853615	1	9	theme	promising	192:200	arg1	therapies					202:210	highly promising therapies	185:210	highly promising therapies for skin damaged sites	185:233	Membranes based on natural polymers are highly promising therapies for skin damaged sites as they can mimic its biological microstructure to support the fibroblasts cells survival and proliferation.
32853615	1	9	theme	promising	192:200	arg1	Membranes					145:153	Membranes	145:153	Membranes based on natural polymers	145:179	Membranes based on natural polymers are highly promising therapies for skin damaged sites as they can mimic its biological microstructure to support the fibroblasts cells survival and proliferation.
32853615	7	10	from	37 °C	1241:1245	arg1	pH 7.4					1230:1235	pH 7.4	1230:1235	pH 7.4	1230:1235	Profiles of the released drug were determined using phosphate-buffered saline (PBS) (pH 7.4) at 37 °C for 30 days.
32853615	7	10	from	37 °C	1241:1245	arg1	saline					1216:1221	phosphate-buffered saline	1197:1221	phosphate-buffered saline (PBS) (pH 7.4) at 37 °C for 30 days	1197:1257	Profiles of the released drug were determined using phosphate-buffered saline (PBS) (pH 7.4) at 37 °C for 30 days.
32853615	7	10	from	37 °C	1241:1245	arg1	PBS					1224:1226	PBS	1224:1226	PBS	1224:1226	Profiles of the released drug were determined using phosphate-buffered saline (PBS) (pH 7.4) at 37 °C for 30 days.
32853615	10	11	theme	polymer	1571:1577	arg1	matrix					1579:1584	the membrane polymer matrix	1558:1584	the membrane polymer matrix	1558:1584	Existence of the nano-particles within the membrane polymer matrix enhanced the membrane stability and enhanced the drug release rate (from 20 to 45%).
32853615	9	12	theme	possible	1427:1434	arg1	interaction					1436:1446	the possible interaction	1423:1446	the possible interaction that takes place among Alg and MC, through presence of hydrogen bonds	1423:1516	The XRD, FTIR and SEM data recognised the possible interaction that takes place among Alg and MC, through presence of hydrogen bonds.
32853615	0	13	theme	cells	138:142	arg1	release					86:92	control drug release	73:92	control drug release	73:92	Dual-function membranes based on alginate/methyl cellulose composite for control drug release and proliferation enhancement of fibroblast cells.
32853615	0	13	theme	cells	138:142	arg1	enhancement					112:122	proliferation enhancement	98:122	proliferation enhancement of fibroblast cells	98:142	Dual-function membranes based on alginate/methyl cellulose composite for control drug release and proliferation enhancement of fibroblast cells.
32853615	13	14	theme	impressive	2082:2091	arg1	effect					2093:2098	an impressive effect	2079:2098	an impressive effect for DOX-loaded membranes on the cells affinity and growth	2079:2156	Cells attachments results have revealed an impressive effect for DOX-loaded membranes on the cells affinity and growth.
32853615	3	15	theme	fibroblast	607:616	arg1	cells					618:622	fibroblast cells	607:622	fibroblast cells	607:622	This research aims to formulate novel medicated membranes for controlled release and cytocompatibility elevation of fibroblast cells for engineering of soft tissue.
32853615	1	16	theme	damaged	221:227	arg1	sites					229:233	skin damaged sites	216:233	skin damaged sites	216:233	Membranes based on natural polymers are highly promising therapies for skin damaged sites as they can mimic its biological microstructure to support the fibroblasts cells survival and proliferation.
32853615	10	17	theme	membrane	1599:1606	arg1	stability					1608:1616	the membrane stability	1595:1616	the membrane stability	1595:1616	Existence of the nano-particles within the membrane polymer matrix enhanced the membrane stability and enhanced the drug release rate (from 20 to 45%).
32853615	3	18	theme	tissue	648:653	arg1	engineering					628:638	engineering	628:638	engineering of soft tissue	628:653	This research aims to formulate novel medicated membranes for controlled release and cytocompatibility elevation of fibroblast cells for engineering of soft tissue.
32853615	11	19	attach	released	1724:1731	arg1	membranes					1757:1765	all the fabricated membranes	1738:1765	all the fabricated membranes	1738:1765	Medication release mechanism elucidated that DOX was released from all the fabricated membranes through the relaxation of polymer matrix that takes place after swelling.
32853615	11	19	attach	released	1724:1731	arg2	mechanism					1690:1698	Medication release mechanism	1671:1698	Medication release mechanism elucidated that DOX	1671:1718	Medication release mechanism elucidated that DOX was released from all the fabricated membranes through the relaxation of polymer matrix that takes place after swelling.
32853615	13	20	dep	cells	2132:2136	arg1	cells					2132:2136	the cells affinity and growth	2128:2156	the cells affinity and growth	2128:2156	Cells attachments results have revealed an impressive effect for DOX-loaded membranes on the cells affinity and growth.
32853615	13	20	dep	cells	2132:2136	arg1	growth					2151:2156	growth	2151:2156	growth	2151:2156	Cells attachments results have revealed an impressive effect for DOX-loaded membranes on the cells affinity and growth.
32853615	13	20	dep	cells	2132:2136	arg1	affinity					2138:2145	affinity	2138:2145	affinity	2138:2145	Cells attachments results have revealed an impressive effect for DOX-loaded membranes on the cells affinity and growth.
32853615	4	21	dep	used	769:772	arg1	loaded					774:779	loaded	774:779	used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique	769:861	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	8	22	theme	cytocompatibility	1285:1301	arg1	investigation					1264:1276	The investigation	1260:1276	The investigation of the cytocompatibility and proliferation of fibroblast cells with the prepared membranes	1260:1367	The investigation of the cytocompatibility and proliferation of fibroblast cells with the prepared membranes were conducted.
32853615	0	23	theme	control	73:79	arg1	release					86:92	control drug release	73:92	control drug release	73:92	Dual-function membranes based on alginate/methyl cellulose composite for control drug release and proliferation enhancement of fibroblast cells.
32853615	5	24	theme	membranes	900:908	arg1	group					885:889	another group	877:889	another group of these membranes	877:908	In addition, another group of these membranes were loaded with DOXycycline antibiotic (DOX) as model drug as well as for eliminating the potential bacterial infections.
32853615	5	24	theme	membranes	900:908	arg1	membranes					900:908	these membranes	894:908	these membranes	894:908	In addition, another group of these membranes were loaded with DOXycycline antibiotic (DOX) as model drug as well as for eliminating the potential bacterial infections.
32853615	5	24	theme	membranes	900:908	arg1	drug					965:968	model drug	959:968	model drug	959:968	In addition, another group of these membranes were loaded with DOXycycline antibiotic (DOX) as model drug as well as for eliminating the potential bacterial infections.
32853615	5	24	theme	membranes	900:908	arg1	eliminating					985:995	eliminating	985:995	eliminating the potential bacterial infections	985:1030	In addition, another group of these membranes were loaded with DOXycycline antibiotic (DOX) as model drug as well as for eliminating the potential bacterial infections.
32853615	4	25	theme	cellulose	749:757	arg1	membranes					707:715	membranes	707:715	membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique	707:861	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	13	26	theme	Cells	2039:2043	arg1	results					2057:2063	Cells attachments results	2039:2063	Cells attachments results	2039:2063	Cells attachments results have revealed an impressive effect for DOX-loaded membranes on the cells affinity and growth.
32853615	8	27	theme	fibroblast	1324:1333	arg1	cells					1335:1339	fibroblast cells	1324:1339	fibroblast cells	1324:1339	The investigation of the cytocompatibility and proliferation of fibroblast cells with the prepared membranes were conducted.
32853615	0	28	theme	proliferation	98:110	arg1	enhancement					112:122	proliferation enhancement	98:122	proliferation enhancement of fibroblast cells	98:142	Dual-function membranes based on alginate/methyl cellulose composite for control drug release and proliferation enhancement of fibroblast cells.
32853615	9	29	theme	bonds	1512:1516	arg1	presence					1491:1498	presence	1491:1498	presence of hydrogen bonds	1491:1516	The XRD, FTIR and SEM data recognised the possible interaction that takes place among Alg and MC, through presence of hydrogen bonds.
32853615	10	30	theme	drug	1635:1638	arg1	rate					1648:1651	the drug release rate	1631:1651	the drug release rate (from 20 to 45%)	1631:1668	Existence of the nano-particles within the membrane polymer matrix enhanced the membrane stability and enhanced the drug release rate (from 20 to 45%).
32853615	12	31	theme	filler	1845:1850	arg1	type					1852:1855	The filler type	1841:1855	The filler type	1841:1855	The filler type and/or dopant type possess no remarkable influence on the cytotoxicity of the membranes against the investigated cells when compared to their individual influence on the same cells.
32853615	2	32	theme	bacterial	470:478	arg1	infection					480:488	the potential bacterial infection	456:488	the potential bacterial infection	456:488	In addition, these membranes could be loaded with active molecules that help in skin regeneration and eliminate the potential bacterial infection.
32853615	8	33	theme	prepared	1350:1357	arg1	membranes					1359:1367	the prepared membranes	1346:1367	the prepared membranes	1346:1367	The investigation of the cytocompatibility and proliferation of fibroblast cells with the prepared membranes were conducted.
32853615	0	34	theme	Dual-function	0:12	arg1	membranes					14:22	Dual-function membranes	0:22	Dual-function membranes based on alginate/methyl cellulose	0:57	Dual-function membranes based on alginate/methyl cellulose composite for control drug release and proliferation enhancement of fibroblast cells.
32853615	1	35	theme	cells	310:314	arg1	survival					316:323	the fibroblasts cells survival	294:323	the fibroblasts cells survival	294:323	Membranes based on natural polymers are highly promising therapies for skin damaged sites as they can mimic its biological microstructure to support the fibroblasts cells survival and proliferation.
32853615	5	36	theme	model	959:963	arg1	group					885:889	another group	877:889	another group of these membranes	877:908	In addition, another group of these membranes were loaded with DOXycycline antibiotic (DOX) as model drug as well as for eliminating the potential bacterial infections.
32853615	5	36	theme	model	959:963	arg1	membranes					900:908	these membranes	894:908	these membranes	894:908	In addition, another group of these membranes were loaded with DOXycycline antibiotic (DOX) as model drug as well as for eliminating the potential bacterial infections.
32853615	5	36	theme	model	959:963	arg1	drug					965:968	model drug	959:968	model drug	959:968	In addition, another group of these membranes were loaded with DOXycycline antibiotic (DOX) as model drug as well as for eliminating the potential bacterial infections.
32853615	14	37	theme	infections	2214:2223	arg1	treatments					2195:2204	treatments	2195:2204	treatments of skin infections	2195:2223	These membranes are recommended for treatments of skin infections.
32853615	2	38	theme	skin	424:427	arg1	regeneration					429:440	skin regeneration	424:440	skin regeneration	424:440	In addition, these membranes could be loaded with active molecules that help in skin regeneration and eliminate the potential bacterial infection.
32853615	0	39	theme	alginate/methyl	33:47	arg1	cellulose					49:57	alginate/methyl cellulose	33:57	alginate/methyl cellulose	33:57	Dual-function membranes based on alginate/methyl cellulose composite for control drug release and proliferation enhancement of fibroblast cells.
32853615	6	40	theme	prepared	1037:1044	arg1	membranes					1046:1054	The prepared membranes	1033:1054	The prepared membranes	1033:1054	The prepared membranes were evaluated by XRD, SEM-EDX, FTIR, Zetasizer, and swelling behaviour was also tested.
32853615	4	41	theme	casting	845:851	arg1	technique					853:861	solvent casting technique	837:861	solvent casting technique	837:861	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	6	42	theme	swelling	1109:1116	arg1	behaviour					1118:1126	swelling behaviour	1109:1126	swelling behaviour	1109:1126	The prepared membranes were evaluated by XRD, SEM-EDX, FTIR, Zetasizer, and swelling behaviour was also tested.
32853615	11	43	theme	release	1682:1688	arg1	mechanism					1690:1698	Medication release mechanism	1671:1698	Medication release mechanism elucidated that DOX	1671:1718	Medication release mechanism elucidated that DOX was released from all the fabricated membranes through the relaxation of polymer matrix that takes place after swelling.
32853615	11	44	theme	matrix	1801:1806	arg1	relaxation					1779:1788	the relaxation	1775:1788	the relaxation of polymer matrix that takes place after swelling	1775:1838	Medication release mechanism elucidated that DOX was released from all the fabricated membranes through the relaxation of polymer matrix that takes place after swelling.
32853615	1	45	theme	natural	164:170	arg1	polymers					172:179	natural polymers	164:179	natural polymers	164:179	Membranes based on natural polymers are highly promising therapies for skin damaged sites as they can mimic its biological microstructure to support the fibroblasts cells survival and proliferation.
32853615	14	46	theme	skin	2209:2212	arg1	infections					2214:2223	skin infections	2209:2223	skin infections	2209:2223	These membranes are recommended for treatments of skin infections.
32853615	10	47	theme	release	1640:1646	arg1	rate					1648:1651	the drug release rate	1631:1651	the drug release rate (from 20 to 45%)	1631:1668	Existence of the nano-particles within the membrane polymer matrix enhanced the membrane stability and enhanced the drug release rate (from 20 to 45%).
32853615	4	48	theme	co-doped	815:822	arg1	undoped					786:792	undoped	786:792	undoped	786:792	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	4	48	theme	co-doped	815:822	arg1	SrTiO3					824:829	Cu co-doped SrTiO3	812:829	Cu co-doped SrTiO3	812:829	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	5	49	theme	potential	1001:1009	arg1	infections					1021:1030	the potential bacterial infections	997:1030	the potential bacterial infections	997:1030	In addition, another group of these membranes were loaded with DOXycycline antibiotic (DOX) as model drug as well as for eliminating the potential bacterial infections.
32853615	3	50	theme	medicated	529:537	arg1	membranes					539:547	novel medicated membranes	523:547	novel medicated membranes	523:547	This research aims to formulate novel medicated membranes for controlled release and cytocompatibility elevation of fibroblast cells for engineering of soft tissue.
32853615	1	51	theme	biological	257:266	arg1	microstructure					268:281	its biological microstructure	253:281	its biological microstructure	253:281	Membranes based on natural polymers are highly promising therapies for skin damaged sites as they can mimic its biological microstructure to support the fibroblasts cells survival and proliferation.
32853615	3	52	theme	cytocompatibility	576:592	arg1	elevation					594:602	cytocompatibility elevation	576:602	cytocompatibility elevation of fibroblast cells	576:622	This research aims to formulate novel medicated membranes for controlled release and cytocompatibility elevation of fibroblast cells for engineering of soft tissue.
32853615	10	53	from	%	1667:1667	arg1	rate					1648:1651	the drug release rate	1631:1651	the drug release rate (from 20 to 45%)	1631:1668	Existence of the nano-particles within the membrane polymer matrix enhanced the membrane stability and enhanced the drug release rate (from 20 to 45%).
32853615	12	54	theme	same	2027:2030	arg1	cells					2032:2036	the same cells	2023:2036	the same cells	2023:2036	The filler type and/or dopant type possess no remarkable influence on the cytotoxicity of the membranes against the investigated cells when compared to their individual influence on the same cells.
32853615	3	55	theme	cells	618:622	arg1	release					564:570	controlled release	553:570	controlled release	553:570	This research aims to formulate novel medicated membranes for controlled release and cytocompatibility elevation of fibroblast cells for engineering of soft tissue.
32853615	3	55	theme	cells	618:622	arg1	elevation					594:602	cytocompatibility elevation	576:602	cytocompatibility elevation of fibroblast cells	576:622	This research aims to formulate novel medicated membranes for controlled release and cytocompatibility elevation of fibroblast cells for engineering of soft tissue.
32853615	8	56	with	proliferation	1307:1319	arg1	membranes					1359:1367	the prepared membranes	1346:1367	the prepared membranes	1346:1367	The investigation of the cytocompatibility and proliferation of fibroblast cells with the prepared membranes were conducted.
32853615	4	57	theme	alginate	727:734	arg1	MC					760:761	MC	760:761	MC	760:761	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	4	57	theme	alginate	727:734	arg1	cellulose					749:757	sodium alginate (Alg)/methyl cellulose	720:757	sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique	720:861	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	10	58	theme	membrane	1562:1569	arg1	matrix					1579:1584	the membrane polymer matrix	1558:1584	the membrane polymer matrix	1558:1584	Existence of the nano-particles within the membrane polymer matrix enhanced the membrane stability and enhanced the drug release rate (from 20 to 45%).
32853615	1	59	theme	skin	216:219	arg1	sites					229:233	skin damaged sites	216:233	skin damaged sites	216:233	Membranes based on natural polymers are highly promising therapies for skin damaged sites as they can mimic its biological microstructure to support the fibroblasts cells survival and proliferation.
32853615	12	60	theme	membranes	1935:1943	arg1	cytotoxicity					1915:1926	the cytotoxicity	1911:1926	the cytotoxicity of the membranes against the investigated cells	1911:1974	The filler type and/or dopant type possess no remarkable influence on the cytotoxicity of the membranes against the investigated cells when compared to their individual influence on the same cells.
32853615	11	61	theme	fabricated	1746:1755	arg1	membranes					1757:1765	all the fabricated membranes	1738:1765	all the fabricated membranes	1738:1765	Medication release mechanism elucidated that DOX was released from all the fabricated membranes through the relaxation of polymer matrix that takes place after swelling.
32853615	3	62	theme	soft	643:646	arg1	tissue					648:653	soft tissue	643:653	soft tissue	643:653	This research aims to formulate novel medicated membranes for controlled release and cytocompatibility elevation of fibroblast cells for engineering of soft tissue.
32853615	11	63	theme	polymer	1793:1799	arg1	matrix					1801:1806	polymer matrix	1793:1806	polymer matrix that takes place after swelling	1793:1838	Medication release mechanism elucidated that DOX was released from all the fabricated membranes through the relaxation of polymer matrix that takes place after swelling.
32853615	13	64	theme	DOX-loaded	2104:2113	arg1	membranes					2115:2123	DOX-loaded membranes	2104:2123	DOX-loaded membranes	2104:2123	Cells attachments results have revealed an impressive effect for DOX-loaded membranes on the cells affinity and growth.
32853615	5	65	theme	antibiotic	939:948	arg1	DOXycycline					927:937	DOXycycline antibiotic	927:948	DOXycycline antibiotic (DOX)	927:954	In addition, another group of these membranes were loaded with DOXycycline antibiotic (DOX) as model drug as well as for eliminating the potential bacterial infections.
32853615	5	65	theme	antibiotic	939:948	arg1	DOX					951:953	DOX	951:953	DOX	951:953	In addition, another group of these membranes were loaded with DOXycycline antibiotic (DOX) as model drug as well as for eliminating the potential bacterial infections.
32853615	0	66	theme	drug	81:84	arg1	release					86:92	control drug release	73:92	control drug release	73:92	Dual-function membranes based on alginate/methyl cellulose composite for control drug release and proliferation enhancement of fibroblast cells.
32853615	4	67	theme	Alg	737:739	arg1	MC					760:761	MC	760:761	MC	760:761	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	4	67	theme	Alg	737:739	arg1	cellulose					749:757	sodium alginate (Alg)/methyl cellulose	720:757	sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique	720:861	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	7	68	theme	phosphate-buffered	1197:1214	arg1	pH 7.4					1230:1235	pH 7.4	1230:1235	pH 7.4	1230:1235	Profiles of the released drug were determined using phosphate-buffered saline (PBS) (pH 7.4) at 37 °C for 30 days.
32853615	7	68	theme	phosphate-buffered	1197:1214	arg1	saline					1216:1221	phosphate-buffered saline	1197:1221	phosphate-buffered saline (PBS) (pH 7.4) at 37 °C for 30 days	1197:1257	Profiles of the released drug were determined using phosphate-buffered saline (PBS) (pH 7.4) at 37 °C for 30 days.
32853615	7	68	theme	phosphate-buffered	1197:1214	arg1	PBS					1224:1226	PBS	1224:1226	PBS	1224:1226	Profiles of the released drug were determined using phosphate-buffered saline (PBS) (pH 7.4) at 37 °C for 30 days.
32853615	12	69	from	influence	2010:2018	arg1	cells					2032:2036	the same cells	2023:2036	the same cells	2023:2036	The filler type and/or dopant type possess no remarkable influence on the cytotoxicity of the membranes against the investigated cells when compared to their individual influence on the same cells.
32853615	4	70	theme	/methyl	741:747	arg1	MC					760:761	MC	760:761	MC	760:761	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	4	70	theme	/methyl	741:747	arg1	cellulose					749:757	sodium alginate (Alg)/methyl cellulose	720:757	sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique	720:861	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	13	71	theme	attachments	2045:2055	arg1	results					2057:2063	Cells attachments results	2039:2063	Cells attachments results	2039:2063	Cells attachments results have revealed an impressive effect for DOX-loaded membranes on the cells affinity and growth.
32853615	12	72	theme	remarkable	1887:1896	arg1	influence					1898:1906	no remarkable influence	1884:1906	no remarkable influence on the cytotoxicity of the membranes against the investigated cells	1884:1974	The filler type and/or dopant type possess no remarkable influence on the cytotoxicity of the membranes against the investigated cells when compared to their individual influence on the same cells.
32853615	9	73	theme	hydrogen	1503:1510	arg1	bonds					1512:1516	hydrogen bonds	1503:1516	hydrogen bonds	1503:1516	The XRD, FTIR and SEM data recognised the possible interaction that takes place among Alg and MC, through presence of hydrogen bonds.
32853615	0	74	theme	fibroblast	127:136	arg1	cells					138:142	fibroblast cells	127:142	fibroblast cells	127:142	Dual-function membranes based on alginate/methyl cellulose composite for control drug release and proliferation enhancement of fibroblast cells.
32853615	8	75	theme	cells	1335:1339	arg1	cytocompatibility					1285:1301	cytocompatibility	1285:1301	cytocompatibility	1285:1301	The investigation of the cytocompatibility and proliferation of fibroblast cells with the prepared membranes were conducted.
32853615	8	75	theme	cells	1335:1339	arg1	proliferation					1307:1319	proliferation	1307:1319	proliferation	1307:1319	The investigation of the cytocompatibility and proliferation of fibroblast cells with the prepared membranes were conducted.
32853615	7	76	theme	drug	1170:1173	arg1	Profiles					1145:1152	Profiles	1145:1152	Profiles of the released drug	1145:1173	Profiles of the released drug were determined using phosphate-buffered saline (PBS) (pH 7.4) at 37 °C for 30 days.
32853615	12	77	theme	dopant	1864:1869	arg1	type					1871:1874	dopant type	1864:1874	dopant type	1864:1874	The filler type and/or dopant type possess no remarkable influence on the cytotoxicity of the membranes against the investigated cells when compared to their individual influence on the same cells.
32853615	2	78	theme	potential	460:468	arg1	infection					480:488	the potential bacterial infection	456:488	the potential bacterial infection	456:488	In addition, these membranes could be loaded with active molecules that help in skin regeneration and eliminate the potential bacterial infection.
32853615	2	79	theme	active	394:399	arg1	molecules					401:409	active molecules	394:409	active molecules that help in skin regeneration and eliminate the potential bacterial infection	394:488	In addition, these membranes could be loaded with active molecules that help in skin regeneration and eliminate the potential bacterial infection.
32853615	1	80	theme	fibroblasts	298:308	arg1	cells					310:314	the fibroblasts cells	294:314	the fibroblasts cells survival	294:323	Membranes based on natural polymers are highly promising therapies for skin damaged sites as they can mimic its biological microstructure to support the fibroblasts cells survival and proliferation.
32853615	10	81	dep	45	1665:1666	arg1	to					1662:1663	to	1662:1663	to	1662:1663	Existence of the nano-particles within the membrane polymer matrix enhanced the membrane stability and enhanced the drug release rate (from 20 to 45%).
32853615	5	82	theme	bacterial	1011:1019	arg1	infections					1021:1030	the potential bacterial infections	997:1030	the potential bacterial infections	997:1030	In addition, another group of these membranes were loaded with DOXycycline antibiotic (DOX) as model drug as well as for eliminating the potential bacterial infections.
32853615	12	83	contain	possess	1876:1882	arg2	influence					1898:1906	no remarkable influence	1884:1906	no remarkable influence on the cytotoxicity of the membranes against the investigated cells	1884:1974	The filler type and/or dopant type possess no remarkable influence on the cytotoxicity of the membranes against the investigated cells when compared to their individual influence on the same cells.
32853615	12	83	contain	possess	1876:1882	arg1	type					1852:1855	The filler type	1841:1855	The filler type	1841:1855	The filler type and/or dopant type possess no remarkable influence on the cytotoxicity of the membranes against the investigated cells when compared to their individual influence on the same cells.
32853615	12	83	contain	possess	1876:1882	arg1	type					1871:1874	dopant type	1864:1874	dopant type	1864:1874	The filler type and/or dopant type possess no remarkable influence on the cytotoxicity of the membranes against the investigated cells when compared to their individual influence on the same cells.
32853615	8	84	dep	cytocompatibility	1285:1301	arg1	the					1281:1283	the	1281:1283	the	1281:1283	The investigation of the cytocompatibility and proliferation of fibroblast cells with the prepared membranes were conducted.
32853615	11	85	theme	Medication	1671:1680	arg1	mechanism					1690:1698	Medication release mechanism	1671:1698	Medication release mechanism elucidated that DOX	1671:1718	Medication release mechanism elucidated that DOX was released from all the fabricated membranes through the relaxation of polymer matrix that takes place after swelling.
32853615	4	86	theme	solvent	837:843	arg1	technique					853:861	solvent casting technique	837:861	solvent casting technique	837:861	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	3	87	theme	novel	523:527	arg1	membranes					539:547	novel medicated membranes	523:547	novel medicated membranes	523:547	This research aims to formulate novel medicated membranes for controlled release and cytocompatibility elevation of fibroblast cells for engineering of soft tissue.
32853615	4	88	theme	Pre-formulation	656:670	arg1	researches					672:681	Pre-formulation researches	656:681	Pre-formulation researches	656:681	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	8	89	with	cytocompatibility	1285:1301	arg1	membranes					1359:1367	the prepared membranes	1346:1367	the prepared membranes	1346:1367	The investigation of the cytocompatibility and proliferation of fibroblast cells with the prepared membranes were conducted.
32853615	8	90	theme	proliferation	1307:1319	arg1	investigation					1264:1276	The investigation	1260:1276	The investigation of the cytocompatibility and proliferation of fibroblast cells with the prepared membranes	1260:1367	The investigation of the cytocompatibility and proliferation of fibroblast cells with the prepared membranes were conducted.
32853615	12	91	from	influence	1898:1906	arg1	cytotoxicity					1915:1926	the cytotoxicity	1911:1926	the cytotoxicity of the membranes against the investigated cells	1911:1974	The filler type and/or dopant type possess no remarkable influence on the cytotoxicity of the membranes against the investigated cells when compared to their individual influence on the same cells.
32853615	4	92	theme	Cu	812:813	arg1	undoped					786:792	undoped	786:792	undoped	786:792	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	4	92	theme	Cu	812:813	arg1	SrTiO3					824:829	Cu co-doped SrTiO3	812:829	Cu co-doped SrTiO3	812:829	Pre-formulation researches have been conducted for membranes of sodium alginate (Alg)/methyl cellulose (MC) that used loaded with undoped, Bi doped and Bi, Cu co-doped SrTiO3 using solvent casting technique.
32853615	3	93	theme	controlled	553:562	arg1	release					564:570	controlled release	553:570	controlled release	553:570	This research aims to formulate novel medicated membranes for controlled release and cytocompatibility elevation of fibroblast cells for engineering of soft tissue.
32853615	9	94	theme	XRD	1389:1391	arg1	data					1407:1410	The XRD, FTIR and SEM data	1385:1410	The XRD, FTIR and SEM data	1385:1410	The XRD, FTIR and SEM data recognised the possible interaction that takes place among Alg and MC, through presence of hydrogen bonds.
34474896	11	0	theme	photoprotective	1899:1913	arg1	properties					1915:1924	safe, biocompatible and photoprotective properties	1875:1924	safe, biocompatible and photoprotective properties	1875:1924	This work introduces PDA-based nanocomposite hydrogels with safe, biocompatible and photoprotective properties, and provides a melanin-mimicking photoprotection system for the application in sunscreens.
34474896	11	1	with	hydrogels	1860:1868	arg1	properties					1915:1924	safe, biocompatible and photoprotective properties	1875:1924	safe, biocompatible and photoprotective properties	1875:1924	This work introduces PDA-based nanocomposite hydrogels with safe, biocompatible and photoprotective properties, and provides a melanin-mimicking photoprotection system for the application in sunscreens.
34474896	1	2	theme	various	181:187	arg1	mechanisms					215:224	various naturally photoprotective mechanisms	181:224	various naturally photoprotective mechanisms	181:224	Living organisms tend to evolve various naturally photoprotective mechanisms to avoid photodamage.
34474896	11	3	from	application	1991:2001	arg1	sunscreens					2006:2015	sunscreens	2006:2015	sunscreens	2006:2015	This work introduces PDA-based nanocomposite hydrogels with safe, biocompatible and photoprotective properties, and provides a melanin-mimicking photoprotection system for the application in sunscreens.
34474896	6	4	theme	skin	1142:1145	arg1	penetration					1147:1157	skin penetration	1142:1157	skin penetration	1142:1157	The CS-PDAh-GP-HA hydrogels also possess excellent resistance toward skin penetration.
34474896	11	5	theme	safe	1875:1878	arg1	properties					1915:1924	safe, biocompatible and photoprotective properties	1875:1924	safe, biocompatible and photoprotective properties	1875:1924	This work introduces PDA-based nanocomposite hydrogels with safe, biocompatible and photoprotective properties, and provides a melanin-mimicking photoprotection system for the application in sunscreens.
34474896	2	6	dep	a	306:306	arg1	mimic					308:312	mimic	308:312	mimic	308:312	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	0	7	theme	penetration	116:126	arg1	resistance					97:106	highly efficient resistance	80:106	highly efficient resistance of skin penetration and photoprotection	80:146	Functional composite hydrogels entrapping polydopamine hollow nanoparticles for highly efficient resistance of skin penetration and photoprotection.
34474896	7	8	dep	in	1291:1292	arg1	vitro					1294:1298	vitro	1294:1298	vitro	1294:1298	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	5	9	theme	elastic	926:932	arg1	modulus					934:940	an elastic modulus	923:940	an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels	923:1070	The CS-PDAh-GP-HA hydrogels exhibit a shear-thinning flow behavior with an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels.
34474896	4	10	theme	hollow	659:664	arg1	nanoparticles					666:678	hollow nanoparticles	659:678	hollow nanoparticles (PDAh NPs)	659:689	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	4	10	theme	hollow	659:664	arg1	NPs					686:688	PDAh NPs	681:688	PDAh NPs	681:688	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	4	10	theme	hollow	659:664	arg1	PDA					639:641	PDA	639:641	PDA	639:641	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	0	11	theme	skin	111:114	arg1	penetration					116:126	skin penetration	111:126	skin penetration	111:126	Functional composite hydrogels entrapping polydopamine hollow nanoparticles for highly efficient resistance of skin penetration and photoprotection.
34474896	9	12	theme	CS-PDAh-GP-HA	1534:1546	arg1	hydrogels					1548:1556	the CS-PDAh-GP-HA hydrogels	1530:1556	the CS-PDAh-GP-HA hydrogels	1530:1556	When protected by the CS-PDAh-GP-HA hydrogels, the cell viability of NIH-3T3 fibroblasts increases to 96% while it was only 14% in the case of non-protecting group.
34474896	5	13	theme	shear-thinning	889:902	arg1	behavior					909:916	a shear-thinning flow behavior	887:916	a shear-thinning flow behavior	887:916	The CS-PDAh-GP-HA hydrogels exhibit a shear-thinning flow behavior with an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels.
34474896	0	14	theme	photoprotection	132:146	arg1	resistance					97:106	highly efficient resistance	80:106	highly efficient resistance of skin penetration and photoprotection	80:146	Functional composite hydrogels entrapping polydopamine hollow nanoparticles for highly efficient resistance of skin penetration and photoprotection.
34474896	11	15	theme	PDA-based	1836:1844	arg1	hydrogels					1860:1868	PDA-based nanocomposite hydrogels	1836:1868	PDA-based nanocomposite hydrogels with safe, biocompatible and photoprotective properties	1836:1924	This work introduces PDA-based nanocomposite hydrogels with safe, biocompatible and photoprotective properties, and provides a melanin-mimicking photoprotection system for the application in sunscreens.
34474896	5	16	with	300 Pa	945:950	arg1	temperature					980:990	the gel-sol transition temperature	957:990	the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels	957:1070	The CS-PDAh-GP-HA hydrogels exhibit a shear-thinning flow behavior with an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels.
34474896	7	17	theme	UVA	1300:1302	arg1	efficacy					1315:1322	in vitro UVA protection efficacy	1291:1322	in vitro UVA protection efficacy (UVAPE)	1291:1330	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	7	17	theme	UVA	1300:1302	arg1	UVAPE					1325:1329	UVAPE	1325:1329	UVAPE	1325:1329	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	11	18	theme	biocompatible	1881:1893	arg1	properties					1915:1924	safe, biocompatible and photoprotective properties	1875:1924	safe, biocompatible and photoprotective properties	1875:1924	This work introduces PDA-based nanocomposite hydrogels with safe, biocompatible and photoprotective properties, and provides a melanin-mimicking photoprotection system for the application in sunscreens.
34474896	8	19	from	nanoparticles	1387:1399	arg1	hydrogel					1413:1420	CS-GP-HA hydrogel	1404:1420	CS-GP-HA hydrogel	1404:1420	Compared with the TiO2 nanoparticles in CS-GP-HA hydrogel, the CS-PDAh-GP-HA hydrogels show stronger shielding ability in both UVA and UVB regions.
34474896	1	20	theme	photoprotective	199:213	arg1	mechanisms					215:224	various naturally photoprotective mechanisms	181:224	various naturally photoprotective mechanisms	181:224	Living organisms tend to evolve various naturally photoprotective mechanisms to avoid photodamage.
34474896	8	21	dep	UVA	1491:1493	arg1	regions					1503:1509	regions	1503:1509	regions	1503:1509	Compared with the TiO2 nanoparticles in CS-GP-HA hydrogel, the CS-PDAh-GP-HA hydrogels show stronger shielding ability in both UVA and UVB regions.
34474896	5	22	theme	CS-PDAh-GP-HA	855:867	arg1	hydrogels					869:877	The CS-PDAh-GP-HA hydrogels	851:877	The CS-PDAh-GP-HA hydrogels	851:877	The CS-PDAh-GP-HA hydrogels exhibit a shear-thinning flow behavior with an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels.
34474896	7	23	theme	CS-PDAh-GP-HA	1196:1208	arg1	hydrogels					1210:1218	CS-PDAh-GP-HA hydrogels	1196:1218	CS-PDAh-GP-HA hydrogels	1196:1218	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	5	24	theme	300 Pa	945:950	arg1	modulus					934:940	an elastic modulus	923:940	an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels	923:1070	The CS-PDAh-GP-HA hydrogels exhibit a shear-thinning flow behavior with an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels.
34474896	3	25	theme	dark	439:442	arg1	color					444:448	its dark color	435:448	its dark color	435:448	However, the concerns of its dark color, skin penetration and photoprotective efficiency remain yet to be solved.
34474896	0	26	theme	composite	11:19	arg1	hydrogels					21:29	Functional composite hydrogels	0:29	Functional composite hydrogels	0:29	Functional composite hydrogels entrapping polydopamine hollow nanoparticles for highly efficient resistance of skin penetration and photoprotection.
34474896	4	27	theme	melanin-inspired	552:567	arg1	CS-PDAh-GP-HA					594:606	CS-PDAh-GP-HA	594:606	CS-PDAh-GP-HA	594:606	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	4	27	theme	melanin-inspired	552:567	arg1	hydrogels					583:591	melanin-inspired nanocomposite hydrogels	552:591	constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator	540:848	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	10	28	theme	UV	1761:1762	arg1	irradiation					1764:1774	the UV irradiation	1757:1774	the UV irradiation	1757:1774	These results suggest that the CS-PDAh-GP-HA hydrogels could efficiently shield the UV irradiation and protect the skin from photodamage.
34474896	5	29	theme	flow	904:907	arg1	behavior					909:916	a shear-thinning flow behavior	887:916	a shear-thinning flow behavior	887:916	The CS-PDAh-GP-HA hydrogels exhibit a shear-thinning flow behavior with an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels.
34474896	7	30	theme	protection	1304:1313	arg1	efficacy					1315:1322	in vitro UVA protection efficacy	1291:1322	in vitro UVA protection efficacy (UVAPE)	1291:1330	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	7	30	theme	protection	1304:1313	arg1	UVAPE					1325:1329	UVAPE	1325:1329	UVAPE	1325:1329	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	0	31	theme	Functional	0:9	arg1	hydrogels					21:29	Functional composite hydrogels	0:29	Functional composite hydrogels	0:29	Functional composite hydrogels entrapping polydopamine hollow nanoparticles for highly efficient resistance of skin penetration and photoprotection.
34474896	4	32	theme	constructed	540:550	arg1	CS-PDAh-GP-HA					594:606	CS-PDAh-GP-HA	594:606	CS-PDAh-GP-HA	594:606	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	4	32	theme	constructed	540:550	arg1	hydrogels					583:591	melanin-inspired nanocomposite hydrogels	552:591	constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator	540:848	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	3	33	dep	the	419:421	arg1	concerns					423:430	concerns	423:430	concerns	423:430	However, the concerns of its dark color, skin penetration and photoprotective efficiency remain yet to be solved.
34474896	4	34	theme	cross-linked	721:732	arg1	CS-GP-HA					744:751	CS-GP-HA	744:751	CS-GP-HA	744:751	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	4	34	theme	cross-linked	721:732	arg1	hydrogel					734:741	a physically cross-linked hydrogel	708:741	a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator	708:848	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	8	35	theme	CS-GP-HA	1404:1411	arg1	hydrogel					1413:1420	CS-GP-HA hydrogel	1404:1420	CS-GP-HA hydrogel	1404:1420	Compared with the TiO2 nanoparticles in CS-GP-HA hydrogel, the CS-PDAh-GP-HA hydrogels show stronger shielding ability in both UVA and UVB regions.
34474896	2	36	theme	system	388:393	arg1	sunscreen					295:303	an effective sunscreen	282:303	an effective sunscreen	282:303	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	2	36	theme	system	388:393	arg1	polydopamine					260:271	polydopamine	260:271	polydopamine (PDA)	260:277	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	2	36	theme	system	388:393	arg1	component					355:363	the main functional component	335:363	the main functional component of the photoprotective system of human skin	335:407	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	9	37	theme	non-protecting	1655:1668	arg1	group					1670:1674	non-protecting group	1655:1674	non-protecting group	1655:1674	When protected by the CS-PDAh-GP-HA hydrogels, the cell viability of NIH-3T3 fibroblasts increases to 96% while it was only 14% in the case of non-protecting group.
34474896	10	38	from	photodamage	1802:1812	arg1	skin					1792:1795	the skin	1788:1795	the skin from photodamage	1788:1812	These results suggest that the CS-PDAh-GP-HA hydrogels could efficiently shield the UV irradiation and protect the skin from photodamage.
34474896	4	39	contain	have	535:538	arg2	hydrogels					583:591	melanin-inspired nanocomposite hydrogels	552:591	constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator	540:848	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	4	39	contain	have	535:538	arg1	we					532:533	we	532:533	we	532:533	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	4	39	contain	have	535:538	arg2	CS-PDAh-GP-HA					594:606	CS-PDAh-GP-HA	594:606	CS-PDAh-GP-HA	594:606	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	9	40	theme	NIH-3T3	1581:1587	arg1	fibroblasts					1589:1599	NIH-3T3 fibroblasts	1581:1599	NIH-3T3 fibroblasts	1581:1599	When protected by the CS-PDAh-GP-HA hydrogels, the cell viability of NIH-3T3 fibroblasts increases to 96% while it was only 14% in the case of non-protecting group.
34474896	3	41	theme	skin	451:454	arg1	penetration					456:466	skin penetration	451:466	skin penetration	451:466	However, the concerns of its dark color, skin penetration and photoprotective efficiency remain yet to be solved.
34474896	6	42	theme	CS-PDAh-GP-HA	1077:1089	arg1	hydrogels					1091:1099	The CS-PDAh-GP-HA hydrogels	1073:1099	The CS-PDAh-GP-HA hydrogels	1073:1099	The CS-PDAh-GP-HA hydrogels also possess excellent resistance toward skin penetration.
34474896	4	43	theme	nanocomposite	569:581	arg1	CS-PDAh-GP-HA					594:606	CS-PDAh-GP-HA	594:606	CS-PDAh-GP-HA	594:606	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	4	43	theme	nanocomposite	569:581	arg1	hydrogels					583:591	melanin-inspired nanocomposite hydrogels	552:591	constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator	540:848	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	9	44	theme	group	1670:1674	arg1	case					1647:1650	the case	1643:1650	the case of non-protecting group	1643:1674	When protected by the CS-PDAh-GP-HA hydrogels, the cell viability of NIH-3T3 fibroblasts increases to 96% while it was only 14% in the case of non-protecting group.
34474896	4	45	link	cross-linked	721:732	arg1	CS-GP-HA					744:751	CS-GP-HA	744:751	CS-GP-HA	744:751	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	4	45	link	cross-linked	721:732	arg1	hydrogel					734:741	a physically cross-linked hydrogel	708:741	a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator	708:848	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	7	46	theme	sun	1259:1261	arg1	SPF					1282:1284	SPF	1282:1284	SPF	1282:1284	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	7	46	theme	sun	1259:1261	arg1	factor					1274:1279	sun protection factor	1259:1279	sun protection factor (SPF)	1259:1285	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	0	47	theme	hollow	55:60	arg1	nanoparticles					62:74	polydopamine hollow nanoparticles	42:74	polydopamine hollow nanoparticles	42:74	Functional composite hydrogels entrapping polydopamine hollow nanoparticles for highly efficient resistance of skin penetration and photoprotection.
34474896	2	48	theme	main	339:342	arg1	sunscreen					295:303	an effective sunscreen	282:303	an effective sunscreen	282:303	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	2	48	theme	main	339:342	arg1	polydopamine					260:271	polydopamine	260:271	polydopamine (PDA)	260:277	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	2	48	theme	main	339:342	arg1	component					355:363	the main functional component	335:363	the main functional component of the photoprotective system of human skin	335:407	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	5	49	theme	β-GP	1042:1045	arg1	content					1047:1053	the β-GP content	1038:1053	the β-GP content in the hydrogels	1038:1070	The CS-PDAh-GP-HA hydrogels exhibit a shear-thinning flow behavior with an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels.
34474896	8	50	theme	TiO2	1382:1385	arg1	nanoparticles					1387:1399	the TiO2 nanoparticles	1378:1399	the TiO2 nanoparticles in CS-GP-HA hydrogel	1378:1420	Compared with the TiO2 nanoparticles in CS-GP-HA hydrogel, the CS-PDAh-GP-HA hydrogels show stronger shielding ability in both UVA and UVB regions.
34474896	7	51	theme	efficacy	1315:1322	arg1	determination					1242:1254	the determination	1238:1254	the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE)	1238:1330	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	9	52	from	%	1638:1638	arg1	case					1647:1650	the case	1643:1650	the case of non-protecting group	1643:1674	When protected by the CS-PDAh-GP-HA hydrogels, the cell viability of NIH-3T3 fibroblasts increases to 96% while it was only 14% in the case of non-protecting group.
34474896	2	53	theme	skin	404:407	arg1	system					388:393	the photoprotective system	368:393	the photoprotective system of human skin	368:407	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	0	54	theme	polydopamine	42:53	arg1	nanoparticles					62:74	polydopamine hollow nanoparticles	42:74	polydopamine hollow nanoparticles	42:74	Functional composite hydrogels entrapping polydopamine hollow nanoparticles for highly efficient resistance of skin penetration and photoprotection.
34474896	8	55	theme	stronger	1456:1463	arg1	ability					1475:1481	stronger shielding ability	1456:1481	stronger shielding ability	1456:1481	Compared with the TiO2 nanoparticles in CS-GP-HA hydrogel, the CS-PDAh-GP-HA hydrogels show stronger shielding ability in both UVA and UVB regions.
34474896	4	56	theme	hyaluronic	782:791	arg1	acid					793:796	hyaluronic acid	782:796	hyaluronic acid (HA)	782:801	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	4	56	theme	hyaluronic	782:791	arg1	HA					799:800	HA	799:800	HA	799:800	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	7	57	theme	in	1291:1292	arg1	efficacy					1315:1322	in vitro UVA protection efficacy	1291:1322	in vitro UVA protection efficacy (UVAPE)	1291:1330	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	7	57	theme	in	1291:1292	arg1	UVAPE					1325:1329	UVAPE	1325:1329	UVAPE	1325:1329	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	5	58	from	content	1047:1053	arg1	hydrogels					1062:1070	the hydrogels	1058:1070	the hydrogels	1058:1070	The CS-PDAh-GP-HA hydrogels exhibit a shear-thinning flow behavior with an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels.
34474896	6	59	contain	possess	1106:1112	arg1	hydrogels					1091:1099	The CS-PDAh-GP-HA hydrogels	1073:1099	The CS-PDAh-GP-HA hydrogels	1073:1099	The CS-PDAh-GP-HA hydrogels also possess excellent resistance toward skin penetration.
34474896	6	59	contain	possess	1106:1112	arg2	resistance					1124:1133	excellent resistance	1114:1133	excellent resistance toward skin penetration	1114:1157	The CS-PDAh-GP-HA hydrogels also possess excellent resistance toward skin penetration.
34474896	11	60	theme	melanin-mimicking	1942:1958	arg1	system					1976:1981	a melanin-mimicking photoprotection system	1940:1981	a melanin-mimicking photoprotection system for the application in sunscreens	1940:2015	This work introduces PDA-based nanocomposite hydrogels with safe, biocompatible and photoprotective properties, and provides a melanin-mimicking photoprotection system for the application in sunscreens.
34474896	2	61	theme	functional	344:353	arg1	sunscreen					295:303	an effective sunscreen	282:303	an effective sunscreen	282:303	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	2	61	theme	functional	344:353	arg1	polydopamine					260:271	polydopamine	260:271	polydopamine (PDA)	260:277	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	2	61	theme	functional	344:353	arg1	component					355:363	the main functional component	335:363	the main functional component of the photoprotective system of human skin	335:407	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	11	62	theme	nanocomposite	1846:1858	arg1	hydrogels					1860:1868	PDA-based nanocomposite hydrogels	1836:1868	PDA-based nanocomposite hydrogels with safe, biocompatible and photoprotective properties	1836:1924	This work introduces PDA-based nanocomposite hydrogels with safe, biocompatible and photoprotective properties, and provides a melanin-mimicking photoprotection system for the application in sunscreens.
34474896	11	63	theme	photoprotection	1960:1974	arg1	system					1976:1981	a melanin-mimicking photoprotection system	1940:1981	a melanin-mimicking photoprotection system for the application in sunscreens	1940:2015	This work introduces PDA-based nanocomposite hydrogels with safe, biocompatible and photoprotective properties, and provides a melanin-mimicking photoprotection system for the application in sunscreens.
34474896	1	64	theme	Living	149:154	arg1	organisms					156:164	Living organisms	149:164	Living organisms	149:164	Living organisms tend to evolve various naturally photoprotective mechanisms to avoid photodamage.
34474896	8	65	theme	CS-PDAh-GP-HA	1427:1439	arg1	hydrogels					1441:1449	the CS-PDAh-GP-HA hydrogels	1423:1449	the CS-PDAh-GP-HA hydrogels	1423:1449	Compared with the TiO2 nanoparticles in CS-GP-HA hydrogel, the CS-PDAh-GP-HA hydrogels show stronger shielding ability in both UVA and UVB regions.
34474896	7	66	theme	protection	1263:1272	arg1	SPF					1282:1284	SPF	1282:1284	SPF	1282:1284	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	7	66	theme	protection	1263:1272	arg1	factor					1274:1279	sun protection factor	1259:1279	sun protection factor (SPF)	1259:1285	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	8	67	theme	shielding	1465:1473	arg1	ability					1475:1481	stronger shielding ability	1456:1481	stronger shielding ability	1456:1481	Compared with the TiO2 nanoparticles in CS-GP-HA hydrogel, the CS-PDAh-GP-HA hydrogels show stronger shielding ability in both UVA and UVB regions.
34474896	2	68	theme	effective	285:293	arg1	a					306:306	a	306:306	a	306:306	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	2	68	theme	effective	285:293	arg1	sunscreen					295:303	an effective sunscreen	282:303	an effective sunscreen	282:303	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	2	68	theme	effective	285:293	arg1	polydopamine					260:271	polydopamine	260:271	polydopamine (PDA)	260:277	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	2	68	theme	effective	285:293	arg1	component					355:363	the main functional component	335:363	the main functional component of the photoprotective system of human skin	335:407	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	9	69	theme	fibroblasts	1589:1599	arg1	viability					1568:1576	the cell viability	1559:1576	the cell viability of NIH-3T3 fibroblasts	1559:1599	When protected by the CS-PDAh-GP-HA hydrogels, the cell viability of NIH-3T3 fibroblasts increases to 96% while it was only 14% in the case of non-protecting group.
34474896	7	70	theme	factor	1274:1279	arg1	determination					1242:1254	the determination	1238:1254	the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE)	1238:1330	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	10	71	theme	CS-PDAh-GP-HA	1708:1720	arg1	hydrogels					1722:1730	the CS-PDAh-GP-HA hydrogels	1704:1730	the CS-PDAh-GP-HA hydrogels	1704:1730	These results suggest that the CS-PDAh-GP-HA hydrogels could efficiently shield the UV irradiation and protect the skin from photodamage.
34474896	7	72	theme	UV-Vis	1343:1348	arg1	spectroscopy					1350:1361	UV-Vis spectroscopy	1343:1361	UV-Vis spectroscopy	1343:1361	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	3	73	theme	photoprotective	472:486	arg1	efficiency					488:497	photoprotective efficiency	472:497	photoprotective efficiency	472:497	However, the concerns of its dark color, skin penetration and photoprotective efficiency remain yet to be solved.
34474896	9	74	theme	cell	1563:1566	arg1	viability					1568:1576	the cell viability	1559:1576	the cell viability of NIH-3T3 fibroblasts	1559:1599	When protected by the CS-PDAh-GP-HA hydrogels, the cell viability of NIH-3T3 fibroblasts increases to 96% while it was only 14% in the case of non-protecting group.
34474896	0	75	theme	efficient	87:95	arg1	resistance					97:106	highly efficient resistance	80:106	highly efficient resistance of skin penetration and photoprotection	80:146	Functional composite hydrogels entrapping polydopamine hollow nanoparticles for highly efficient resistance of skin penetration and photoprotection.
34474896	5	76	theme	gel-sol	961:967	arg1	transition					969:978	the gel-sol transition	957:978	the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels	957:1070	The CS-PDAh-GP-HA hydrogels exhibit a shear-thinning flow behavior with an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels.
34474896	2	77	theme	photoprotective	372:386	arg1	system					388:393	the photoprotective system	368:393	the photoprotective system of human skin	368:407	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	2	78	theme	human	398:402	arg1	skin					404:407	human skin	398:407	human skin	398:407	Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin.
34474896	6	79	theme	excellent	1114:1122	arg1	resistance					1124:1133	excellent resistance	1114:1133	excellent resistance toward skin penetration	1114:1157	The CS-PDAh-GP-HA hydrogels also possess excellent resistance toward skin penetration.
34474896	5	80	theme	transition	969:978	arg1	temperature					980:990	the gel-sol transition temperature	957:990	the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels	957:1070	The CS-PDAh-GP-HA hydrogels exhibit a shear-thinning flow behavior with an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β-GP content in the hydrogels.
34474896	4	81	theme	PDAh	681:684	arg1	nanoparticles					666:678	hollow nanoparticles	659:678	hollow nanoparticles (PDAh NPs)	659:689	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	4	81	theme	PDAh	681:684	arg1	NPs					686:688	PDAh NPs	681:688	PDAh NPs	681:688	Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDAh-GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDAh NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β-glycerophosphate (β-GP) as a modulator.
34474896	7	82	theme	photoprotective	1164:1178	arg1	performances					1180:1191	The photoprotective performances	1160:1191	The photoprotective performances of CS-PDAh-GP-HA hydrogels	1160:1218	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
34474896	7	83	theme	hydrogels	1210:1218	arg1	performances					1180:1191	The photoprotective performances	1160:1191	The photoprotective performances of CS-PDAh-GP-HA hydrogels	1160:1218	The photoprotective performances of CS-PDAh-GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV-Vis spectroscopy.
33966824	6	0	theme	bleaching	905:913	arg1	low					925:927	low	925:927	low	925:927	However, the degree of bleaching (DoB) was low without the use of ozone.
33966824	6	0	theme	bleaching	905:913	arg1	degree					895:900	the degree	891:900	the degree of bleaching (DoB)	891:919	However, the degree of bleaching (DoB) was low without the use of ozone.
33966824	0	1	theme	viscosity	68:76	arg1	control					78:84	better viscosity control	61:84	better viscosity control	61:84	Partial exchange of ozone by electron beam irradiation shows better viscosity control and less oxidation in cellulose upgrade scenarios.
33966824	1	2	theme	cellulose	237:245	arg1	pulps					247:251	cellulose pulps	237:251	cellulose pulps	237:251	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	3	3	from	effects	563:569	arg1	HexA					599:602	HexA	599:602	HexA	599:602	Additionally, effects of EBI on hexenuronic acid (HexA) and xylan were investigated.
33966824	3	3	from	effects	563:569	arg1	xylan					609:613	xylan	609:613	xylan	609:613	Additionally, effects of EBI on hexenuronic acid (HexA) and xylan were investigated.
33966824	3	3	from	effects	563:569	arg1	acid					593:596	hexenuronic acid	581:596	hexenuronic acid (HexA)	581:603	Additionally, effects of EBI on hexenuronic acid (HexA) and xylan were investigated.
33966824	4	4	theme	mL	661:662	arg1	g-1					664:666	450-500 mL g-1	653:666	450-500 mL g-1	653:666	IV was adjusted to 450-500 mL g-1 and properties including carbonyl content, kappa, brightness, alkali-resistance and sugar composition were compared.
33966824	2	5	theme	free	464:467	arg1	sequences					485:493	totally chlorine free (TCF) bleaching sequences	447:493	totally chlorine free (TCF) bleaching sequences comprising either EBI, ozone, or both for IV control	447:546	Both eucalyptus kraft (EK) paper pulp and beech sulfite (BS) dissolving pulp were subjected to totally chlorine free (TCF) bleaching sequences comprising either EBI, ozone, or both for IV control.
33966824	1	6	theme	conventional	330:341	arg1	methods					343:349	conventional methods	330:349	conventional methods	330:349	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	6	7	theme	ozone	948:952	arg1	use					941:943	the use	937:943	the use of ozone	937:952	However, the degree of bleaching (DoB) was low without the use of ozone.
33966824	2	8	theme	BS	409:410	arg1	pulp					424:427	beech sulfite (BS) dissolving pulp	394:427	beech sulfite (BS) dissolving pulp	394:427	Both eucalyptus kraft (EK) paper pulp and beech sulfite (BS) dissolving pulp were subjected to totally chlorine free (TCF) bleaching sequences comprising either EBI, ozone, or both for IV control.
33966824	7	9	theme	birch	973:977	arg1	pulp					979:982	a birch pulp	971:982	a birch pulp	971:982	HexA content in a birch pulp was halved by EBI.
33966824	7	10	theme	HexA	955:958	arg1	content					960:966	HexA content	955:966	HexA content in a birch pulp	955:982	HexA content in a birch pulp was halved by EBI.
33966824	2	11	theme	sulfite	400:406	arg1	pulp					424:427	beech sulfite (BS) dissolving pulp	394:427	beech sulfite (BS) dissolving pulp	394:427	Both eucalyptus kraft (EK) paper pulp and beech sulfite (BS) dissolving pulp were subjected to totally chlorine free (TCF) bleaching sequences comprising either EBI, ozone, or both for IV control.
33966824	2	12	theme	kraft	368:372	arg1	pulp					385:388	eucalyptus kraft (EK) paper pulp	357:388	eucalyptus kraft (EK) paper pulp	357:388	Both eucalyptus kraft (EK) paper pulp and beech sulfite (BS) dissolving pulp were subjected to totally chlorine free (TCF) bleaching sequences comprising either EBI, ozone, or both for IV control.
33966824	8	13	theme	Isolated	1003:1010	arg1	xylans					1012:1017	Isolated xylans	1003:1017	Isolated xylans	1003:1017	Isolated xylans were more resistant to irradiation than cellulose with little decrease of molar masses and moderate oxidation.
33966824	8	14	with	resistant	1029:1037	arg1	decrease					1081:1088	little decrease	1074:1088	little decrease of molar masses	1074:1104	Isolated xylans were more resistant to irradiation than cellulose with little decrease of molar masses and moderate oxidation.
33966824	8	14	with	resistant	1029:1037	arg1	oxidation					1119:1127	moderate oxidation	1110:1127	moderate oxidation	1110:1127	Isolated xylans were more resistant to irradiation than cellulose with little decrease of molar masses and moderate oxidation.
33966824	2	15	theme	eucalyptus	357:366	arg1	pulp					385:388	eucalyptus kraft (EK) paper pulp	357:388	eucalyptus kraft (EK) paper pulp	357:388	Both eucalyptus kraft (EK) paper pulp and beech sulfite (BS) dissolving pulp were subjected to totally chlorine free (TCF) bleaching sequences comprising either EBI, ozone, or both for IV control.
33966824	0	16	theme	Partial	0:6	arg1	exchange					8:15	Partial exchange	0:15	Partial exchange of ozone by electron beam irradiation	0:53	Partial exchange of ozone by electron beam irradiation shows better viscosity control and less oxidation in cellulose upgrade scenarios.
33966824	7	17	from	content	960:966	arg1	pulp					979:982	a birch pulp	971:982	a birch pulp	971:982	HexA content in a birch pulp was halved by EBI.
33966824	3	18	theme	hexenuronic	581:591	arg1	HexA					599:602	HexA	599:602	HexA	599:602	Additionally, effects of EBI on hexenuronic acid (HexA) and xylan were investigated.
33966824	3	18	theme	hexenuronic	581:591	arg1	acid					593:596	hexenuronic acid	581:596	hexenuronic acid (HexA)	581:603	Additionally, effects of EBI on hexenuronic acid (HexA) and xylan were investigated.
33966824	8	19	theme	moderate	1110:1117	arg1	oxidation					1119:1127	moderate oxidation	1110:1127	moderate oxidation	1110:1127	Isolated xylans were more resistant to irradiation than cellulose with little decrease of molar masses and moderate oxidation.
33966824	0	20	theme	ozone	20:24	arg1	exchange					8:15	Partial exchange	0:15	Partial exchange of ozone by electron beam irradiation	0:53	Partial exchange of ozone by electron beam irradiation shows better viscosity control and less oxidation in cellulose upgrade scenarios.
33966824	0	21	theme	upgrade	118:124	arg1	scenarios					126:134	cellulose upgrade scenarios	108:134	cellulose upgrade scenarios	108:134	Partial exchange of ozone by electron beam irradiation shows better viscosity control and less oxidation in cellulose upgrade scenarios.
33966824	4	22	theme	450-500	653:659	arg1	g-1					664:666	450-500 mL g-1	653:666	450-500 mL g-1	653:666	IV was adjusted to 450-500 mL g-1 and properties including carbonyl content, kappa, brightness, alkali-resistance and sugar composition were compared.
33966824	1	23	theme	alternative	175:185	arg1	treatment					187:195	an alternative treatment	172:195	an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps	172:251	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	1	23	theme	alternative	175:185	arg1	irradiation					151:161	Electron beam irradiation	137:161	Electron beam irradiation (EBI)	137:167	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	0	24	theme	cellulose	108:116	arg1	scenarios					126:134	cellulose upgrade scenarios	108:134	cellulose upgrade scenarios	108:134	Partial exchange of ozone by electron beam irradiation shows better viscosity control and less oxidation in cellulose upgrade scenarios.
33966824	0	25	from	control	78:84	arg1	scenarios					126:134	cellulose upgrade scenarios	108:134	cellulose upgrade scenarios	108:134	Partial exchange of ozone by electron beam irradiation shows better viscosity control and less oxidation in cellulose upgrade scenarios.
33966824	5	26	theme	cellulose	861:869	arg1	alkali-resistance					822:838	a higher alkali-resistance	813:838	a higher alkali-resistance	813:838	Pulps produced with EBI had a higher alkali-resistance, uniformity and less cellulose oxidation.
33966824	5	26	theme	cellulose	861:869	arg1	oxidation					871:879	less cellulose oxidation	856:879	less cellulose oxidation	856:879	Pulps produced with EBI had a higher alkali-resistance, uniformity and less cellulose oxidation.
33966824	2	27	theme	paper	379:383	arg1	pulp					385:388	eucalyptus kraft (EK) paper pulp	357:388	eucalyptus kraft (EK) paper pulp	357:388	Both eucalyptus kraft (EK) paper pulp and beech sulfite (BS) dissolving pulp were subjected to totally chlorine free (TCF) bleaching sequences comprising either EBI, ozone, or both for IV control.
33966824	0	28	theme	electron	29:36	arg1	irradiation					43:53	electron beam irradiation	29:53	electron beam irradiation	29:53	Partial exchange of ozone by electron beam irradiation shows better viscosity control and less oxidation in cellulose upgrade scenarios.
33966824	1	29	from	control	226:232	arg1	pulps					247:251	cellulose pulps	237:251	cellulose pulps	237:251	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	3	30	theme	EBI	574:576	arg1	effects					563:569	effects	563:569	effects of EBI on hexenuronic acid (HexA) and xylan	563:613	Additionally, effects of EBI on hexenuronic acid (HexA) and xylan were investigated.
33966824	2	31	theme	dissolving	413:422	arg1	pulp					424:427	beech sulfite (BS) dissolving pulp	394:427	beech sulfite (BS) dissolving pulp	394:427	Both eucalyptus kraft (EK) paper pulp and beech sulfite (BS) dissolving pulp were subjected to totally chlorine free (TCF) bleaching sequences comprising either EBI, ozone, or both for IV control.
33966824	8	32	theme	little	1074:1079	arg1	decrease					1081:1088	little decrease	1074:1088	little decrease of molar masses	1074:1104	Isolated xylans were more resistant to irradiation than cellulose with little decrease of molar masses and moderate oxidation.
33966824	2	33	theme	beech	394:398	arg1	pulp					424:427	beech sulfite (BS) dissolving pulp	394:427	beech sulfite (BS) dissolving pulp	394:427	Both eucalyptus kraft (EK) paper pulp and beech sulfite (BS) dissolving pulp were subjected to totally chlorine free (TCF) bleaching sequences comprising either EBI, ozone, or both for IV control.
33966824	2	34	theme	EK	375:376	arg1	pulp					385:388	eucalyptus kraft (EK) paper pulp	357:388	eucalyptus kraft (EK) paper pulp	357:388	Both eucalyptus kraft (EK) paper pulp and beech sulfite (BS) dissolving pulp were subjected to totally chlorine free (TCF) bleaching sequences comprising either EBI, ozone, or both for IV control.
33966824	8	35	theme	molar	1093:1097	arg1	masses					1099:1104	molar masses	1093:1104	molar masses	1093:1104	Isolated xylans were more resistant to irradiation than cellulose with little decrease of molar masses and moderate oxidation.
33966824	4	36	theme	sugar	752:756	arg1	composition					758:768	sugar composition	752:768	sugar composition	752:768	IV was adjusted to 450-500 mL g-1 and properties including carbonyl content, kappa, brightness, alkali-resistance and sugar composition were compared.
33966824	0	37	theme	beam	38:41	arg1	irradiation					43:53	electron beam irradiation	29:53	electron beam irradiation	29:53	Partial exchange of ozone by electron beam irradiation shows better viscosity control and less oxidation in cellulose upgrade scenarios.
33966824	2	38	dep	free	464:467	arg1	TCF					470:472	TCF	470:472	TCF	470:472	Both eucalyptus kraft (EK) paper pulp and beech sulfite (BS) dissolving pulp were subjected to totally chlorine free (TCF) bleaching sequences comprising either EBI, ozone, or both for IV control.
33966824	5	39	theme	higher	815:820	arg1	uniformity					841:850	uniformity	841:850	uniformity	841:850	Pulps produced with EBI had a higher alkali-resistance, uniformity and less cellulose oxidation.
33966824	5	39	theme	higher	815:820	arg1	alkali-resistance					822:838	a higher alkali-resistance	813:838	a higher alkali-resistance	813:838	Pulps produced with EBI had a higher alkali-resistance, uniformity and less cellulose oxidation.
33966824	5	39	theme	higher	815:820	arg1	oxidation					871:879	less cellulose oxidation	856:879	less cellulose oxidation	856:879	Pulps produced with EBI had a higher alkali-resistance, uniformity and less cellulose oxidation.
33966824	1	40	theme	full	287:290	arg1	sequences					302:310	full bleaching sequences	287:310	full bleaching sequences for comparison to conventional methods	287:349	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	0	41	from	oxidation	95:103	arg1	scenarios					126:134	cellulose upgrade scenarios	108:134	cellulose upgrade scenarios	108:134	Partial exchange of ozone by electron beam irradiation shows better viscosity control and less oxidation in cellulose upgrade scenarios.
33966824	4	42	theme	carbonyl	693:700	arg1	content					702:708	carbonyl content	693:708	carbonyl content	693:708	IV was adjusted to 450-500 mL g-1 and properties including carbonyl content, kappa, brightness, alkali-resistance and sugar composition were compared.
33966824	1	43	theme	viscosity	211:219	arg1	control					226:232	intrinsic viscosity (IV) control	201:232	intrinsic viscosity (IV) control in cellulose pulps	201:251	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	5	44	contain	had	809:811	arg2	uniformity					841:850	uniformity	841:850	uniformity	841:850	Pulps produced with EBI had a higher alkali-resistance, uniformity and less cellulose oxidation.
33966824	5	44	contain	had	809:811	arg2	alkali-resistance					822:838	a higher alkali-resistance	813:838	a higher alkali-resistance	813:838	Pulps produced with EBI had a higher alkali-resistance, uniformity and less cellulose oxidation.
33966824	5	44	contain	had	809:811	arg2	oxidation					871:879	less cellulose oxidation	856:879	less cellulose oxidation	856:879	Pulps produced with EBI had a higher alkali-resistance, uniformity and less cellulose oxidation.
33966824	5	44	contain	had	809:811	arg1	Pulps					785:789	Pulps	785:789	Pulps produced with EBI	785:807	Pulps produced with EBI had a higher alkali-resistance, uniformity and less cellulose oxidation.
33966824	0	45	theme	better	61:66	arg1	control					78:84	better viscosity control	61:84	better viscosity control	61:84	Partial exchange of ozone by electron beam irradiation shows better viscosity control and less oxidation in cellulose upgrade scenarios.
33966824	1	46	theme	intrinsic	201:209	arg1	IV					222:223	IV	222:223	IV	222:223	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	1	46	theme	intrinsic	201:209	arg1	viscosity					211:219	intrinsic viscosity	201:219	intrinsic viscosity (IV) control in cellulose pulps	201:251	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	1	47	theme	Electron	137:144	arg1	treatment					187:195	an alternative treatment	172:195	an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps	172:251	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	1	47	theme	Electron	137:144	arg1	EBI					164:166	EBI	164:166	EBI	164:166	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	1	47	theme	Electron	137:144	arg1	irradiation					151:161	Electron beam irradiation	137:161	Electron beam irradiation (EBI)	137:167	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	8	48	theme	masses	1099:1104	arg1	decrease					1081:1088	little decrease	1074:1088	little decrease of molar masses	1074:1104	Isolated xylans were more resistant to irradiation than cellulose with little decrease of molar masses and moderate oxidation.
33966824	8	48	theme	masses	1099:1104	arg1	oxidation					1119:1127	moderate oxidation	1110:1127	moderate oxidation	1110:1127	Isolated xylans were more resistant to irradiation than cellulose with little decrease of molar masses and moderate oxidation.
33966824	1	49	theme	bleaching	292:300	arg1	sequences					302:310	full bleaching sequences	287:310	full bleaching sequences for comparison to conventional methods	287:349	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	1	50	theme	beam	146:149	arg1	treatment					187:195	an alternative treatment	172:195	an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps	172:251	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	1	50	theme	beam	146:149	arg1	EBI					164:166	EBI	164:166	EBI	164:166	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	1	50	theme	beam	146:149	arg1	irradiation					151:161	Electron beam irradiation	137:161	Electron beam irradiation (EBI)	137:167	Electron beam irradiation (EBI) is an alternative treatment for intrinsic viscosity (IV) control in cellulose pulps, but has never been integrated in full bleaching sequences for comparison to conventional methods.
33966824	2	51	theme	bleaching	475:483	arg1	sequences					485:493	totally chlorine free (TCF) bleaching sequences	447:493	totally chlorine free (TCF) bleaching sequences comprising either EBI, ozone, or both for IV control	447:546	Both eucalyptus kraft (EK) paper pulp and beech sulfite (BS) dissolving pulp were subjected to totally chlorine free (TCF) bleaching sequences comprising either EBI, ozone, or both for IV control.
33255021	2	0	theme	scaffolds	312:320	arg1	bioactivation					291:303	The bioactivation	287:303	The bioactivation of the scaffolds	287:320	The bioactivation of the scaffolds was accomplished by using organic (BMP-2 peptide) and inorganic (hydroxyapatite nanoparticles) cues.
33255021	5	1	theme	tissue	1010:1015	arg1	formation					1017:1025	endothelial tissue formation	998:1025	endothelial tissue formation (tube formation)	998:1042	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	5	1	theme	tissue	1010:1015	arg1	formation					1033:1041	tube formation	1028:1041	tube formation	1028:1041	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	6	2	from	neovascularization	1168:1185	arg1	field					1244:1248	regenerative medicine field	1222:1248	regenerative medicine field	1222:1248	Taken together, the results emphasized the concept that bioactive CS/PEGDA scaffolds may be novel implants for stimulating neovascularization of tissue-engineered constructs in regenerative medicine field.
33255021	1	3	theme	PEGDA	212:216	arg1	scaffolds					225:233	bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds	154:233	bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds	154:233	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
33255021	6	4	theme	tissue-engineered	1190:1206	arg1	constructs					1208:1217	tissue-engineered constructs	1190:1217	tissue-engineered constructs	1190:1217	Taken together, the results emphasized the concept that bioactive CS/PEGDA scaffolds may be novel implants for stimulating neovascularization of tissue-engineered constructs in regenerative medicine field.
33255021	3	5	theme	biological	482:491	arg1	promotion					502:510	biological response promotion	482:510	biological response promotion on human umbilical vein endothelial cells (HUVECs)	482:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	5	6	from	effect	916:921	arg1	response					937:944	angiogenic response	926:944	angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation)	926:1042	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	5	7	theme	scaffolds	879:887	arg1	surface					889:895	CS/PEGDA scaffolds surface	870:895	CS/PEGDA scaffolds surface	870:895	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	4	8	theme	cells	817:821	arg1	steps					745:749	two important steps	731:749	two important steps involved in angiogenesis process: migration and tube formation of cells	731:821	Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells.
33255021	4	8	theme	cells	817:821	arg1	migration					785:793	migration	785:793	migration	785:793	Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells.
33255021	4	8	theme	cells	817:821	arg1	formation					804:812	tube formation	799:812	tube formation of cells	799:821	Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells.
33255021	3	9	from	materials	460:468	arg1	terms					473:477	terms	473:477	terms of biological response promotion on human umbilical vein endothelial cells (HUVECs)	473:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	3	10	theme	response	493:500	arg1	promotion					502:510	biological response promotion	482:510	biological response promotion on human umbilical vein endothelial cells (HUVECs)	482:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	1	11	theme	based	219:223	arg1	scaffolds					225:233	bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds	154:233	bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds	154:233	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
33255021	4	12	dep	steps	745:749	arg1	steps					745:749	two important steps	731:749	two important steps involved in angiogenesis process: migration and tube formation of cells	731:821	Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells.
33255021	4	12	dep	steps	745:749	arg1	migration					785:793	migration	785:793	migration	785:793	Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells.
33255021	4	12	dep	steps	745:749	arg1	formation					804:812	tube formation	799:812	tube formation of cells	799:821	Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells.
33255021	1	13	dep	in	256:257	arg1	vitro					259:263	vitro	259:263	vitro	259:263	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
33255021	2	14	dep	inorganic	376:384	arg1	nanoparticles					402:414	hydroxyapatite nanoparticles	387:414	hydroxyapatite nanoparticles	387:414	The bioactivation of the scaffolds was accomplished by using organic (BMP-2 peptide) and inorganic (hydroxyapatite nanoparticles) cues.
33255021	0	15	theme	Chitosan/PEGDA	0:13	arg1	based					15:19	Chitosan/PEGDA based	0:19	Chitosan/PEGDA based	0:19	Chitosan/PEGDA based scaffolds as bioinspired materials to control in vitro angiogenesis.
33255021	1	16	theme	bioactive	154:162	arg1	chitosan					164:171	bioactive chitosan	154:171	bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds	154:233	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
33255021	1	16	theme	bioactive	154:162	arg1	glycol					192:197	ethylene glycol	183:197	ethylene glycol	183:197	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
33255021	1	16	theme	bioactive	154:162	arg1	CS					174:175	CS	174:175	CS	174:175	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
33255021	6	17	theme	CS/PEGDA	1111:1118	arg1	scaffolds					1120:1128	bioactive CS/PEGDA scaffolds	1101:1128	bioactive CS/PEGDA scaffolds	1101:1128	Taken together, the results emphasized the concept that bioactive CS/PEGDA scaffolds may be novel implants for stimulating neovascularization of tissue-engineered constructs in regenerative medicine field.
33255021	4	18	theme	tube	799:802	arg1	steps					745:749	two important steps	731:749	two important steps involved in angiogenesis process: migration and tube formation of cells	731:821	Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells.
33255021	4	18	theme	tube	799:802	arg1	formation					804:812	tube formation	799:812	tube formation of cells	799:821	Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells.
33255021	3	19	dep	cell	622:625	arg1	proliferation					638:650	proliferation	638:650	proliferation	638:650	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	3	19	dep	cell	622:625	arg1	growth					627:632	growth	627:632	growth	627:632	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	3	20	theme	human	515:519	arg1	cells					548:552	human umbilical vein endothelial cells	515:552	human umbilical vein endothelial cells (HUVECs)	515:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	3	20	theme	human	515:519	arg1	HUVECs					555:560	HUVECs	555:560	HUVECs	555:560	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	1	21	theme	chitosan	164:171	arg1	scaffolds					225:233	bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds	154:233	bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds	154:233	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
33255021	2	22	theme	hydroxyapatite	387:400	arg1	nanoparticles					402:414	hydroxyapatite nanoparticles	387:414	hydroxyapatite nanoparticles	387:414	The bioactivation of the scaffolds was accomplished by using organic (BMP-2 peptide) and inorganic (hydroxyapatite nanoparticles) cues.
33255021	1	23	theme	scaffolds	225:233	arg1	assessment					140:149	the assessment	136:149	the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process	136:284	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
33255021	6	24	theme	regenerative	1222:1233	arg1	medicine					1235:1242	regenerative medicine	1222:1242	regenerative medicine field	1222:1248	Taken together, the results emphasized the concept that bioactive CS/PEGDA scaffolds may be novel implants for stimulating neovascularization of tissue-engineered constructs in regenerative medicine field.
33255021	3	25	theme	umbilical	521:529	arg1	cells					548:552	human umbilical vein endothelial cells	515:552	human umbilical vein endothelial cells (HUVECs)	515:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	3	25	theme	umbilical	521:529	arg1	HUVECs					555:560	HUVECs	555:560	HUVECs	555:560	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	3	26	from	properties	442:451	arg1	terms					473:477	terms	473:477	terms of biological response promotion on human umbilical vein endothelial cells (HUVECs)	473:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	1	27	theme	current	97:103	arg1	work					105:108	the current work	93:108	the current work	93:108	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
33255021	5	28	from	signals	859:865	arg1	surface					889:895	CS/PEGDA scaffolds surface	870:895	CS/PEGDA scaffolds surface	870:895	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	5	29	theme	desirable	906:914	arg1	effect					916:921	a desirable effect	904:921	a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation)	904:1042	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	2	30	theme	inorganic	376:384	arg1	cues					417:420	organic (BMP-2 peptide) and inorganic (hydroxyapatite nanoparticles) cues	348:420	organic (BMP-2 peptide) and inorganic (hydroxyapatite nanoparticles) cues	348:420	The bioactivation of the scaffolds was accomplished by using organic (BMP-2 peptide) and inorganic (hydroxyapatite nanoparticles) cues.
33255021	6	31	theme	novel	1137:1141	arg1	implants					1143:1150	novel implants	1137:1150	novel implants	1137:1150	Taken together, the results emphasized the concept that bioactive CS/PEGDA scaffolds may be novel implants for stimulating neovascularization of tissue-engineered constructs in regenerative medicine field.
33255021	3	32	theme	in	585:586	arg1	tests					607:611	in vitro angiogenesis tests	585:611	in vitro angiogenesis tests based on cell growth and proliferation	585:650	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	0	33	dep	in	67:68	arg1	vitro					70:74	vitro	70:74	vitro	70:74	Chitosan/PEGDA based scaffolds as bioinspired materials to control in vitro angiogenesis.
33255021	3	34	from	cells	548:552	arg1	terms					473:477	terms	473:477	terms of biological response promotion on human umbilical vein endothelial cells (HUVECs)	473:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	6	35	theme	bioactive	1101:1109	arg1	scaffolds					1120:1128	bioactive CS/PEGDA scaffolds	1101:1128	bioactive CS/PEGDA scaffolds	1101:1128	Taken together, the results emphasized the concept that bioactive CS/PEGDA scaffolds may be novel implants for stimulating neovascularization of tissue-engineered constructs in regenerative medicine field.
33255021	5	36	theme	marker	968:973	arg1	CD-31					987:991	CD-31	987:991	CD-31	987:991	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	5	36	theme	marker	968:973	arg1	expression					975:984	angiogenic marker expression	957:984	angiogenic marker expression (CD-31)	957:992	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	5	37	theme	tube	1028:1031	arg1	formation					1017:1025	endothelial tissue formation	998:1025	endothelial tissue formation (tube formation)	998:1042	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	5	37	theme	tube	1028:1031	arg1	formation					1033:1041	tube formation	1028:1041	tube formation	1028:1041	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	0	38	theme	bioinspired	34:44	arg1	materials					46:54	bioinspired materials	34:54	bioinspired materials	34:54	Chitosan/PEGDA based scaffolds as bioinspired materials to control in vitro angiogenesis.
33255021	1	39	theme	in	256:257	arg1	process					278:284	in vitro angiogenesis process	256:284	in vitro angiogenesis process	256:284	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
33255021	6	40	theme	constructs	1208:1217	arg1	neovascularization					1168:1185	neovascularization	1168:1185	neovascularization of tissue-engineered constructs in regenerative medicine field	1168:1248	Taken together, the results emphasized the concept that bioactive CS/PEGDA scaffolds may be novel implants for stimulating neovascularization of tissue-engineered constructs in regenerative medicine field.
33255021	2	41	theme	BMP-2	357:361	arg1	peptide					363:369	BMP-2 peptide	357:369	BMP-2 peptide	357:369	The bioactivation of the scaffolds was accomplished by using organic (BMP-2 peptide) and inorganic (hydroxyapatite nanoparticles) cues.
33255021	4	42	theme	angiogenesis	763:774	arg1	process					776:782	angiogenesis process	763:782	angiogenesis process	763:782	Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells.
33255021	3	43	theme	vein	531:534	arg1	cells					548:552	human umbilical vein endothelial cells	515:552	human umbilical vein endothelial cells (HUVECs)	515:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	3	43	theme	vein	531:534	arg1	HUVECs					555:560	HUVECs	555:560	HUVECs	555:560	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	5	44	theme	bioactive	849:857	arg1	signals					859:865	bioactive signals	849:865	bioactive signals on CS/PEGDA scaffolds surface	849:895	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	1	45	theme	angiogenesis	265:276	arg1	process					278:284	in vitro angiogenesis process	256:284	in vitro angiogenesis process	256:284	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
33255021	3	46	theme	endothelial	536:546	arg1	cells					548:552	human umbilical vein endothelial cells	515:552	human umbilical vein endothelial cells (HUVECs)	515:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	3	46	theme	endothelial	536:546	arg1	HUVECs					555:560	HUVECs	555:560	HUVECs	555:560	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	3	47	from	promotion	502:510	arg1	cells					548:552	human umbilical vein endothelial cells	515:552	human umbilical vein endothelial cells (HUVECs)	515:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	3	47	from	promotion	502:510	arg1	HUVECs					555:560	HUVECs	555:560	HUVECs	555:560	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	4	48	theme	important	735:743	arg1	steps					745:749	two important steps	731:749	two important steps involved in angiogenesis process: migration and tube formation of cells	731:821	Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells.
33255021	4	48	theme	important	735:743	arg1	migration					785:793	migration	785:793	migration	785:793	Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells.
33255021	4	48	theme	important	735:743	arg1	formation					804:812	tube formation	799:812	tube formation of cells	799:821	Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells.
33255021	5	49	theme	endothelial	998:1008	arg1	formation					1017:1025	endothelial tissue formation	998:1025	endothelial tissue formation (tube formation)	998:1042	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	5	49	theme	endothelial	998:1008	arg1	formation					1033:1041	tube formation	1028:1041	tube formation	1028:1041	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	6	50	theme	medicine	1235:1242	arg1	field					1244:1248	regenerative medicine field	1222:1248	regenerative medicine field	1222:1248	Taken together, the results emphasized the concept that bioactive CS/PEGDA scaffolds may be novel implants for stimulating neovascularization of tissue-engineered constructs in regenerative medicine field.
33255021	3	51	theme	promotion	502:510	arg1	terms					473:477	terms	473:477	terms of biological response promotion on human umbilical vein endothelial cells (HUVECs)	473:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	1	52	theme	ethylene	183:190	arg1	chitosan					164:171	bioactive chitosan	154:171	bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds	154:233	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
33255021	1	52	theme	ethylene	183:190	arg1	glycol					192:197	ethylene glycol	183:197	ethylene glycol	183:197	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
33255021	5	53	theme	angiogenic	926:935	arg1	response					937:944	angiogenic response	926:944	angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation)	926:1042	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	3	54	theme	angiogenesis	594:605	arg1	tests					607:611	in vitro angiogenesis tests	585:611	in vitro angiogenesis tests based on cell growth and proliferation	585:650	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	4	55	theme	scaffolds	698:706	arg1	capability					708:717	the scaffolds capability	694:717	the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells	694:821	Furthermore, our interest was to examine the scaffolds capability to modulate two important steps involved in angiogenesis process: migration and tube formation of cells.
33255021	5	56	theme	angiogenic	957:966	arg1	CD-31					987:991	CD-31	987:991	CD-31	987:991	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	5	56	theme	angiogenic	957:966	arg1	expression					975:984	angiogenic marker expression	957:984	angiogenic marker expression (CD-31)	957:992	Our data underlined that bioactive signals on CS/PEGDA scaffolds surface induce a desirable effect on angiogenic response concerning angiogenic marker expression (CD-31) and endothelial tissue formation (tube formation).
33255021	3	57	theme	materials	460:468	arg1	properties					442:451	the properties	438:451	the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs)	438:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	2	58	theme	organic	348:354	arg1	cues					417:420	organic (BMP-2 peptide) and inorganic (hydroxyapatite nanoparticles) cues	348:420	organic (BMP-2 peptide) and inorganic (hydroxyapatite nanoparticles) cues	348:420	The bioactivation of the scaffolds was accomplished by using organic (BMP-2 peptide) and inorganic (hydroxyapatite nanoparticles) cues.
33255021	3	59	dep	in	585:586	arg1	vitro					588:592	vitro	588:592	vitro	588:592	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	0	60	theme	in	67:68	arg1	angiogenesis					76:87	in vitro angiogenesis	67:87	in vitro angiogenesis	67:87	Chitosan/PEGDA based scaffolds as bioinspired materials to control in vitro angiogenesis.
33255021	2	61	dep	organic	348:354	arg1	peptide					363:369	BMP-2 peptide	357:369	BMP-2 peptide	357:369	The bioactivation of the scaffolds was accomplished by using organic (BMP-2 peptide) and inorganic (hydroxyapatite nanoparticles) cues.
33255021	3	62	from	terms	473:477	arg1	cells					548:552	human umbilical vein endothelial cells	515:552	human umbilical vein endothelial cells (HUVECs)	515:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	3	62	from	terms	473:477	arg1	properties					442:451	the properties	438:451	the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs)	438:561	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	3	62	from	terms	473:477	arg1	HUVECs					555:560	HUVECs	555:560	HUVECs	555:560	In particular, the properties of the materials in terms of biological response promotion on human umbilical vein endothelial cells (HUVECs) were studied by using in vitro angiogenesis tests based on cell growth and proliferation.
33255021	1	63	theme	diacrylate	200:209	arg1	scaffolds					225:233	bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds	154:233	bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds	154:233	In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process.
34756149	5	0	theme	chitosan	735:742	arg1	films					744:748	chitosan films	735:748	chitosan films	735:748	The properties of chitosan films can be improved through the formation of composites by inserting nanoclays as montmorillonite in the polymeric matrix.
34756149	6	1	theme	study	891:895	arg1	objective					873:881	The objective	869:881	The objective of this study	869:895	The objective of this study was to develop and characterize chitosan/montmorillonite nanocomposites for fruit coating aiming for future applications in the field of smart packaging.
34756149	2	2	theme	biodegradability	348:363	arg1	properties					384:393	its biocompatibility, biodegradability, and antimicrobial properties	326:393	its biocompatibility, biodegradability, and antimicrobial properties	326:393	Chitosan, which presents a potential for chemical modifications and capacity to form films, can be an alternative for coating due to its biocompatibility, biodegradability, and antimicrobial properties.
34756149	6	3	theme	future	998:1003	arg1	applications					1005:1016	future applications	998:1016	future applications in the field of smart packaging	998:1048	The objective of this study was to develop and characterize chitosan/montmorillonite nanocomposites for fruit coating aiming for future applications in the field of smart packaging.
34756149	5	4	theme	films	744:748	arg1	properties					721:730	The properties	717:730	The properties of chitosan films	717:748	The properties of chitosan films can be improved through the formation of composites by inserting nanoclays as montmorillonite in the polymeric matrix.
34756149	6	5	from	applications	1005:1016	arg1	field					1025:1029	the field	1021:1029	the field of smart packaging	1021:1048	The objective of this study was to develop and characterize chitosan/montmorillonite nanocomposites for fruit coating aiming for future applications in the field of smart packaging.
34756149	3	6	theme	selective	573:581	arg1	permeability					583:594	selective permeability	573:594	selective permeability	573:594	Chitosan film can be obtained through casting method presenting suitable mechanical properties, such as resistance to traction and elongation, ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2.
34756149	9	7	theme	0.5	1360:1362	arg1	%					1363:1363	%	1363:1363	%	1363:1363	Nanocomposites became more transparent and significantly reduced its water permeability rate with 0.5% w/w montmorillonite addition.
34756149	7	8	theme	mechanical	1117:1126	arg1	properties					1149:1158	thermal, mechanical, and physicochemical properties	1108:1158	thermal, mechanical, and physicochemical properties	1108:1158	Nanocomposites were characterized by its microstructure, thermal, mechanical, and physicochemical properties.
34756149	7	8	theme	mechanical	1117:1126	arg1	microstructure					1092:1105	its microstructure	1088:1105	its microstructure	1088:1105	Nanocomposites were characterized by its microstructure, thermal, mechanical, and physicochemical properties.
34756149	10	9	theme	films	1440:1444	arg1	rigidity					1403:1410	Elastic rigidity	1395:1410	Elastic rigidity	1395:1410	Elastic rigidity and tensile strength of the films were improved.
34756149	10	9	theme	films	1440:1444	arg1	strength					1424:1431	tensile strength	1416:1431	tensile strength	1416:1431	Elastic rigidity and tensile strength of the films were improved.
34756149	1	10	theme	fruits	136:141	arg1	life					149:152	fruits shelf life	136:152	fruits shelf life	136:152	Edible coating can improve fruits shelf life and, consequently, reduce their waste.
34756149	11	11	theme	Chitosan/montmorillonite	1461:1484	arg1	nanocomposites					1486:1499	Chitosan/montmorillonite nanocomposites	1461:1499	Chitosan/montmorillonite nanocomposites	1461:1499	Chitosan/montmorillonite nanocomposites demonstrated the potential to improve the storage time of Williams pears.
34756149	9	12	theme	w/w	1365:1367	arg1	addition					1385:1392	0.5% w/w montmorillonite addition	1360:1392	0.5% w/w montmorillonite addition	1360:1392	Nanocomposites became more transparent and significantly reduced its water permeability rate with 0.5% w/w montmorillonite addition.
34756149	7	13	theme	thermal	1108:1114	arg1	properties					1149:1158	thermal, mechanical, and physicochemical properties	1108:1158	thermal, mechanical, and physicochemical properties	1108:1158	Nanocomposites were characterized by its microstructure, thermal, mechanical, and physicochemical properties.
34756149	7	13	theme	thermal	1108:1114	arg1	microstructure					1092:1105	its microstructure	1088:1105	its microstructure	1088:1105	Nanocomposites were characterized by its microstructure, thermal, mechanical, and physicochemical properties.
34756149	9	14	theme	montmorillonite	1369:1383	arg1	addition					1385:1392	0.5% w/w montmorillonite addition	1360:1392	0.5% w/w montmorillonite addition	1360:1392	Nanocomposites became more transparent and significantly reduced its water permeability rate with 0.5% w/w montmorillonite addition.
34756149	1	15	theme	Edible	109:114	arg1	coating					116:122	Edible coating	109:122	Edible coating	109:122	Edible coating can improve fruits shelf life and, consequently, reduce their waste.
34756149	9	16	theme	%	1363:1363	arg1	addition					1385:1392	0.5% w/w montmorillonite addition	1360:1392	0.5% w/w montmorillonite addition	1360:1392	Nanocomposites became more transparent and significantly reduced its water permeability rate with 0.5% w/w montmorillonite addition.
34756149	3	17	theme	Chitosan	396:403	arg1	film					405:408	Chitosan film	396:408	Chitosan film	396:408	Chitosan film can be obtained through casting method presenting suitable mechanical properties, such as resistance to traction and elongation, ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2.
34756149	6	18	theme	fruit	973:977	arg1	coating					979:985	fruit coating	973:985	fruit coating aiming for future applications in the field of smart packaging	973:1048	The objective of this study was to develop and characterize chitosan/montmorillonite nanocomposites for fruit coating aiming for future applications in the field of smart packaging.
34756149	4	19	theme	coating	704:710	arg1	use					712:714	its potential coating use	690:714	its potential coating use	690:714	However, it is highly permeable to water vapor, which can limit its potential coating use.
34756149	8	20	theme	X-ray	1161:1165	arg1	analysis					1179:1186	X-ray diffraction analysis	1161:1186	X-ray diffraction analysis	1161:1186	X-ray diffraction analysis indicated changes in crystallinity with the insertion of montmorillonite.
34756149	5	21	theme	polymeric	851:859	arg1	matrix					861:866	the polymeric matrix	847:866	the polymeric matrix	847:866	The properties of chitosan films can be improved through the formation of composites by inserting nanoclays as montmorillonite in the polymeric matrix.
34756149	5	22	theme	composites	791:800	arg1	formation					778:786	the formation	774:786	the formation of composites	774:800	The properties of chitosan films can be improved through the formation of composites by inserting nanoclays as montmorillonite in the polymeric matrix.
34756149	11	23	theme	storage	1543:1549	arg1	time					1551:1554	the storage time	1539:1554	the storage time of Williams pears	1539:1572	Chitosan/montmorillonite nanocomposites demonstrated the potential to improve the storage time of Williams pears.
34756149	6	24	theme	packaging	1040:1048	arg1	field					1025:1029	the field	1021:1029	the field of smart packaging	1021:1048	The objective of this study was to develop and characterize chitosan/montmorillonite nanocomposites for fruit coating aiming for future applications in the field of smart packaging.
34756149	6	25	theme	chitosan/montmorillonite	929:952	arg1	nanocomposites					954:967	chitosan/montmorillonite nanocomposites	929:967	chitosan/montmorillonite nanocomposites for fruit coating aiming for future applications in the field of smart packaging	929:1048	The objective of this study was to develop and characterize chitosan/montmorillonite nanocomposites for fruit coating aiming for future applications in the field of smart packaging.
34756149	6	26	theme	smart	1034:1038	arg1	packaging					1040:1048	smart packaging	1034:1048	smart packaging	1034:1048	The objective of this study was to develop and characterize chitosan/montmorillonite nanocomposites for fruit coating aiming for future applications in the field of smart packaging.
34756149	3	27	theme	casting	434:440	arg1	method					442:447	casting method	434:447	casting method presenting suitable mechanical properties, such as resistance to traction and elongation, ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2	434:623	Chitosan film can be obtained through casting method presenting suitable mechanical properties, such as resistance to traction and elongation, ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2.
34756149	3	28	theme	suitable	460:467	arg1	resistance					500:509	resistance	500:509	resistance to traction and elongation	500:536	Chitosan film can be obtained through casting method presenting suitable mechanical properties, such as resistance to traction and elongation, ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2.
34756149	3	28	theme	suitable	460:467	arg1	ability					539:545	ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2	539:623	ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2	539:623	Chitosan film can be obtained through casting method presenting suitable mechanical properties, such as resistance to traction and elongation, ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2.
34756149	3	28	theme	suitable	460:467	arg1	properties					480:489	suitable mechanical properties	460:489	suitable mechanical properties	460:489	Chitosan film can be obtained through casting method presenting suitable mechanical properties, such as resistance to traction and elongation, ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2.
34756149	0	29	theme	chitosan/montmorillonite	34:57	arg1	characterization					14:29	characterization	14:29	characterization	14:29	Synthesis and characterization of chitosan/montmorillonite nanocomposites for application as edible coating.
34756149	0	29	theme	chitosan/montmorillonite	34:57	arg1	Synthesis					0:8	Synthesis	0:8	Synthesis	0:8	Synthesis and characterization of chitosan/montmorillonite nanocomposites for application as edible coating.
34756149	2	30	theme	chemical	234:241	arg1	modifications					243:255	chemical modifications	234:255	chemical modifications	234:255	Chitosan, which presents a potential for chemical modifications and capacity to form films, can be an alternative for coating due to its biocompatibility, biodegradability, and antimicrobial properties.
34756149	3	31	theme	mechanical	469:478	arg1	resistance					500:509	resistance	500:509	resistance to traction and elongation	500:536	Chitosan film can be obtained through casting method presenting suitable mechanical properties, such as resistance to traction and elongation, ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2.
34756149	3	31	theme	mechanical	469:478	arg1	ability					539:545	ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2	539:623	ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2	539:623	Chitosan film can be obtained through casting method presenting suitable mechanical properties, such as resistance to traction and elongation, ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2.
34756149	3	31	theme	mechanical	469:478	arg1	properties					480:489	suitable mechanical properties	460:489	suitable mechanical properties	460:489	Chitosan film can be obtained through casting method presenting suitable mechanical properties, such as resistance to traction and elongation, ability to adhere to surfaces and selective permeability to gases, such as O2 and CO2.
34756149	7	32	theme	physicochemical	1133:1147	arg1	properties					1149:1158	thermal, mechanical, and physicochemical properties	1108:1158	thermal, mechanical, and physicochemical properties	1108:1158	Nanocomposites were characterized by its microstructure, thermal, mechanical, and physicochemical properties.
34756149	7	32	theme	physicochemical	1133:1147	arg1	microstructure					1092:1105	its microstructure	1088:1105	its microstructure	1088:1105	Nanocomposites were characterized by its microstructure, thermal, mechanical, and physicochemical properties.
34756149	2	33	theme	antimicrobial	370:382	arg1	properties					384:393	its biocompatibility, biodegradability, and antimicrobial properties	326:393	its biocompatibility, biodegradability, and antimicrobial properties	326:393	Chitosan, which presents a potential for chemical modifications and capacity to form films, can be an alternative for coating due to its biocompatibility, biodegradability, and antimicrobial properties.
34756149	10	34	theme	Elastic	1395:1401	arg1	rigidity					1403:1410	Elastic rigidity	1395:1410	Elastic rigidity	1395:1410	Elastic rigidity and tensile strength of the films were improved.
34756149	2	35	theme	biocompatibility	330:345	arg1	properties					384:393	its biocompatibility, biodegradability, and antimicrobial properties	326:393	its biocompatibility, biodegradability, and antimicrobial properties	326:393	Chitosan, which presents a potential for chemical modifications and capacity to form films, can be an alternative for coating due to its biocompatibility, biodegradability, and antimicrobial properties.
34756149	8	36	theme	montmorillonite	1245:1259	arg1	insertion					1232:1240	the insertion	1228:1240	the insertion of montmorillonite	1228:1259	X-ray diffraction analysis indicated changes in crystallinity with the insertion of montmorillonite.
34756149	8	37	from	changes	1198:1204	arg1	crystallinity					1209:1221	crystallinity	1209:1221	crystallinity	1209:1221	X-ray diffraction analysis indicated changes in crystallinity with the insertion of montmorillonite.
34756149	9	38	theme	permeability	1337:1348	arg1	rate					1350:1353	its water permeability rate	1327:1353	its water permeability rate	1327:1353	Nanocomposites became more transparent and significantly reduced its water permeability rate with 0.5% w/w montmorillonite addition.
34756149	1	39	theme	shelf	143:147	arg1	life					149:152	fruits shelf life	136:152	fruits shelf life	136:152	Edible coating can improve fruits shelf life and, consequently, reduce their waste.
34756149	4	40	theme	potential	694:702	arg1	use					712:714	its potential coating use	690:714	its potential coating use	690:714	However, it is highly permeable to water vapor, which can limit its potential coating use.
34756149	10	41	theme	tensile	1416:1422	arg1	strength					1424:1431	tensile strength	1416:1431	tensile strength	1416:1431	Elastic rigidity and tensile strength of the films were improved.
34756149	1	42	dep	improve	128:134	arg1	reduce					173:178	reduce	173:178	reduce their waste	173:190	Edible coating can improve fruits shelf life and, consequently, reduce their waste.
34756149	11	43	theme	Williams	1559:1566	arg1	pears					1568:1572	Williams pears	1559:1572	Williams pears	1559:1572	Chitosan/montmorillonite nanocomposites demonstrated the potential to improve the storage time of Williams pears.
34756149	0	44	theme	edible	93:98	arg1	coating					100:106	edible coating	93:106	edible coating	93:106	Synthesis and characterization of chitosan/montmorillonite nanocomposites for application as edible coating.
34756149	11	45	theme	pears	1568:1572	arg1	time					1551:1554	the storage time	1539:1554	the storage time of Williams pears	1539:1572	Chitosan/montmorillonite nanocomposites demonstrated the potential to improve the storage time of Williams pears.
34756149	9	46	theme	water	1331:1335	arg1	permeability					1337:1348	its water permeability	1327:1348	its water permeability rate	1327:1353	Nanocomposites became more transparent and significantly reduced its water permeability rate with 0.5% w/w montmorillonite addition.
34756149	5	47	from	montmorillonite	828:842	arg1	matrix					861:866	the polymeric matrix	847:866	the polymeric matrix	847:866	The properties of chitosan films can be improved through the formation of composites by inserting nanoclays as montmorillonite in the polymeric matrix.
34756149	4	48	theme	water	661:665	arg1	vapor					667:671	water vapor	661:671	water vapor	661:671	However, it is highly permeable to water vapor, which can limit its potential coating use.
34756149	8	49	theme	diffraction	1167:1177	arg1	analysis					1179:1186	X-ray diffraction analysis	1161:1186	X-ray diffraction analysis	1161:1186	X-ray diffraction analysis indicated changes in crystallinity with the insertion of montmorillonite.
34296596	0	0	theme	Multifunctional	125:139	arg1	Dressing					147:154	Multifunctional Wound Dressing	125:154	Multifunctional Wound Dressing	125:154	Functionalization of Aminoalkylsilane-Grafted Bacterial Nanocellulose with ZnO-NPs-Doped Pullulan Electrospun Nanofibers for Multifunctional Wound Dressing.
34296596	5	1	used	used	769:772	arg2	aminoalkylsilane					697:712	aminoalkylsilane	697:712	aminoalkylsilane	697:712	In this study, aminoalkylsilane was chemically grafted on a BNC membrane (A-g-BNC) and used as a bridge to combine BNC with Pul-ZnO-NPs hybrid electrospun nanofibers.
34296596	5	1	used	used	769:772	arg2	bridge					779:784	a bridge	777:784	a bridge	777:784	In this study, aminoalkylsilane was chemically grafted on a BNC membrane (A-g-BNC) and used as a bridge to combine BNC with Pul-ZnO-NPs hybrid electrospun nanofibers.
34296596	11	2	theme	excellent	1533:1541	arg1	activity					1557:1564	excellent antibacterial activity	1533:1564	excellent antibacterial activity	1533:1564	The new functional dressing, fabricated with a cost-effective and easy method, not only showed excellent antibacterial activity but could also accelerate wound healing.
34296596	1	3	theme	bacterial	297:305	arg1	nanocellulose					307:319	bacterial nanocellulose	297:319	bacterial nanocellulose (BNC)	297:325	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	1	3	theme	bacterial	297:305	arg1	BNC					322:324	BNC	322:324	BNC	322:324	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	2	4	theme	healing-promoting	450:466	arg1	ability					468:474	healing-promoting ability	450:474	healing-promoting ability	450:474	The lack of antibacterial activity and healing-promoting ability are the main drawbacks that limit its wide application.
34296596	1	5	theme	wound	394:398	arg1	dressings					400:408	wound dressings	394:408	especially wound dressings	383:408	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	1	5	theme	wound	394:398	arg1	production					371:380	biomedical device production	353:380	biomedical device production	353:380	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	11	6	theme	easy	1504:1507	arg1	method					1509:1514	a cost-effective and easy method	1483:1514	a cost-effective and easy method	1483:1514	The new functional dressing, fabricated with a cost-effective and easy method, not only showed excellent antibacterial activity but could also accelerate wound healing.
34296596	3	7	theme	nontoxic	552:559	arg1	polymer					561:567	a nontoxic polymer	550:567	a nontoxic polymer that can promote wound healing	550:598	Pullulan (Pul) is a nontoxic polymer that can promote wound healing.
34296596	3	7	theme	nontoxic	552:559	arg1	Pullulan					532:539	Pullulan	532:539	Pullulan (Pul)	532:545	Pullulan (Pul) is a nontoxic polymer that can promote wound healing.
34296596	8	8	theme	antibacterial	1060:1072	arg1	activity					1074:1081	its antibacterial activity	1056:1081	its antibacterial activity	1056:1081	The dressing showed an ability to release ZnO, and its antibacterial activity was up to 5 log values higher than that of BNC.
34296596	10	9	theme	collagen	1377:1384	arg1	synthesis					1386:1394	collagen synthesis	1377:1394	collagen synthesis	1377:1394	The animal test in a rat model indicated faster healing and re-epithelialization, small blood vessel formation, and collagen synthesis in the wounds covered by A-g-BNC/Pul-ZnO.
34296596	3	10	theme	wound	586:590	arg1	healing					592:598	wound healing	586:598	wound healing	586:598	Pullulan (Pul) is a nontoxic polymer that can promote wound healing.
34296596	10	11	theme	animal	1265:1270	arg1	test					1272:1275	The animal test	1261:1275	The animal test in a rat model	1261:1290	The animal test in a rat model indicated faster healing and re-epithelialization, small blood vessel formation, and collagen synthesis in the wounds covered by A-g-BNC/Pul-ZnO.
34296596	0	12	theme	Wound	141:145	arg1	Dressing					147:154	Multifunctional Wound Dressing	125:154	Multifunctional Wound Dressing	125:154	Functionalization of Aminoalkylsilane-Grafted Bacterial Nanocellulose with ZnO-NPs-Doped Pullulan Electrospun Nanofibers for Multifunctional Wound Dressing.
34296596	11	13	theme	antibacterial	1543:1555	arg1	activity					1557:1564	excellent antibacterial activity	1533:1564	excellent antibacterial activity	1533:1564	The new functional dressing, fabricated with a cost-effective and easy method, not only showed excellent antibacterial activity but could also accelerate wound healing.
34296596	10	14	theme	faster	1302:1307	arg1	healing					1309:1315	faster healing	1302:1315	faster healing	1302:1315	The animal test in a rat model indicated faster healing and re-epithelialization, small blood vessel formation, and collagen synthesis in the wounds covered by A-g-BNC/Pul-ZnO.
34296596	11	15	theme	functional	1446:1455	arg1	dressing					1457:1464	The new functional dressing	1438:1464	The new functional dressing	1438:1464	The new functional dressing, fabricated with a cost-effective and easy method, not only showed excellent antibacterial activity but could also accelerate wound healing.
34296596	1	16	from	properties	206:215	arg1	state					226:230	a wet state	220:230	a wet state	220:230	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	1	17	theme	wet	222:224	arg1	state					226:230	a wet state	220:230	a wet state	220:230	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	5	18	theme	Pul-ZnO-NPs	806:816	arg1	nanofibers					837:846	Pul-ZnO-NPs hybrid electrospun nanofibers	806:846	Pul-ZnO-NPs hybrid electrospun nanofibers	806:846	In this study, aminoalkylsilane was chemically grafted on a BNC membrane (A-g-BNC) and used as a bridge to combine BNC with Pul-ZnO-NPs hybrid electrospun nanofibers.
34296596	11	19	theme	wound	1592:1596	arg1	healing					1598:1604	wound healing	1592:1604	wound healing	1592:1604	The new functional dressing, fabricated with a cost-effective and easy method, not only showed excellent antibacterial activity but could also accelerate wound healing.
34296596	11	20	theme	new	1442:1444	arg1	dressing					1457:1464	The new functional dressing	1438:1464	The new functional dressing	1438:1464	The new functional dressing, fabricated with a cost-effective and easy method, not only showed excellent antibacterial activity but could also accelerate wound healing.
34296596	10	21	theme	small	1343:1347	arg1	formation					1362:1370	small blood vessel formation	1343:1370	small blood vessel formation	1343:1370	The animal test in a rat model indicated faster healing and re-epithelialization, small blood vessel formation, and collagen synthesis in the wounds covered by A-g-BNC/Pul-ZnO.
34296596	5	22	theme	hybrid	818:823	arg1	nanofibers					837:846	Pul-ZnO-NPs hybrid electrospun nanofibers	806:846	Pul-ZnO-NPs hybrid electrospun nanofibers	806:846	In this study, aminoalkylsilane was chemically grafted on a BNC membrane (A-g-BNC) and used as a bridge to combine BNC with Pul-ZnO-NPs hybrid electrospun nanofibers.
34296596	8	23	theme	log	1095:1097	arg1	values					1099:1104	up to 5 log values	1087:1104	up to 5 log values	1087:1104	The dressing showed an ability to release ZnO, and its antibacterial activity was up to 5 log values higher than that of BNC.
34296596	10	24	from	test	1272:1275	arg1	model					1286:1290	a rat model	1280:1290	a rat model	1280:1290	The animal test in a rat model indicated faster healing and re-epithelialization, small blood vessel formation, and collagen synthesis in the wounds covered by A-g-BNC/Pul-ZnO.
34296596	10	25	theme	rat	1282:1284	arg1	model					1286:1290	a rat model	1280:1290	a rat model	1280:1290	The animal test in a rat model indicated faster healing and re-epithelialization, small blood vessel formation, and collagen synthesis in the wounds covered by A-g-BNC/Pul-ZnO.
34296596	2	26	theme	activity	437:444	arg1	drawbacks					489:497	the main drawbacks	480:497	the main drawbacks that limit its wide application	480:529	The lack of antibacterial activity and healing-promoting ability are the main drawbacks that limit its wide application.
34296596	2	26	theme	activity	437:444	arg1	lack					415:418	The lack	411:418	The lack of antibacterial activity and healing-promoting ability	411:474	The lack of antibacterial activity and healing-promoting ability are the main drawbacks that limit its wide application.
34296596	5	27	theme	electrospun	825:835	arg1	nanofibers					837:846	Pul-ZnO-NPs hybrid electrospun nanofibers	806:846	Pul-ZnO-NPs hybrid electrospun nanofibers	806:846	In this study, aminoalkylsilane was chemically grafted on a BNC membrane (A-g-BNC) and used as a bridge to combine BNC with Pul-ZnO-NPs hybrid electrospun nanofibers.
34296596	4	28	theme	Zinc	601:604	arg1	ZnO-NPs					627:633	ZnO-NPs	627:633	ZnO-NPs	627:633	Zinc oxide nanoparticles (ZnO-NPs) are well-known as a safe antibacterial agent.
34296596	4	28	theme	Zinc	601:604	arg1	nanoparticles					612:624	Zinc oxide nanoparticles	601:624	Zinc oxide nanoparticles (ZnO-NPs)	601:634	Zinc oxide nanoparticles (ZnO-NPs) are well-known as a safe antibacterial agent.
34296596	7	29	theme	better	980:985	arg1	performance					968:978	blood clotting performance	953:978	blood clotting performance better than that of BNC	953:1002	The obtained dressing demonstrated blood clotting performance better than that of BNC.
34296596	1	30	theme	high	233:236	arg1	capability					252:261	high water-holding capability	233:261	high water-holding capability	233:261	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	0	31	theme	Bacterial	46:54	arg1	Nanocellulose					56:68	Aminoalkylsilane-Grafted Bacterial Nanocellulose	21:68	Aminoalkylsilane-Grafted Bacterial Nanocellulose	21:68	Functionalization of Aminoalkylsilane-Grafted Bacterial Nanocellulose with ZnO-NPs-Doped Pullulan Electrospun Nanofibers for Multifunctional Wound Dressing.
34296596	1	32	from	permeability	171:182	arg1	state					226:230	a wet state	220:230	a wet state	220:230	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	11	33	theme	cost-effective	1485:1498	arg1	method					1509:1514	a cost-effective and easy method	1483:1514	a cost-effective and easy method	1483:1514	The new functional dressing, fabricated with a cost-effective and easy method, not only showed excellent antibacterial activity but could also accelerate wound healing.
34296596	1	34	theme	water-holding	238:250	arg1	capability					252:261	high water-holding capability	233:261	high water-holding capability	233:261	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	0	35	theme	Aminoalkylsilane-Grafted	21:44	arg1	Nanocellulose					56:68	Aminoalkylsilane-Grafted Bacterial Nanocellulose	21:68	Aminoalkylsilane-Grafted Bacterial Nanocellulose	21:68	Functionalization of Aminoalkylsilane-Grafted Bacterial Nanocellulose with ZnO-NPs-Doped Pullulan Electrospun Nanofibers for Multifunctional Wound Dressing.
34296596	1	36	theme	favorable	329:337	arg1	candidate					339:347	a favorable candidate	327:347	a favorable candidate for biomedical device production, especially wound dressings	327:408	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	5	37	theme	BNC	742:744	arg1	A-g-BNC					756:762	A-g-BNC	756:762	A-g-BNC	756:762	In this study, aminoalkylsilane was chemically grafted on a BNC membrane (A-g-BNC) and used as a bridge to combine BNC with Pul-ZnO-NPs hybrid electrospun nanofibers.
34296596	5	37	theme	BNC	742:744	arg1	membrane					746:753	a BNC membrane	740:753	a BNC membrane (A-g-BNC)	740:763	In this study, aminoalkylsilane was chemically grafted on a BNC membrane (A-g-BNC) and used as a bridge to combine BNC with Pul-ZnO-NPs hybrid electrospun nanofibers.
34296596	6	38	theme	A-g-BNC/Pul-ZnO	901:915	arg1	production					887:896	the successful production	872:896	the successful production of A-g-BNC/Pul-ZnO	872:915	FTIR results confirmed the successful production of A-g-BNC/Pul-ZnO.
34296596	1	39	theme	High	157:160	arg1	permeability					171:182	High moisture permeability	157:182	High moisture permeability	157:182	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	4	40	theme	antibacterial	661:673	arg1	agent					675:679	a safe antibacterial agent	654:679	a safe antibacterial agent	654:679	Zinc oxide nanoparticles (ZnO-NPs) are well-known as a safe antibacterial agent.
34296596	4	41	theme	oxide	606:610	arg1	ZnO-NPs					627:633	ZnO-NPs	627:633	ZnO-NPs	627:633	Zinc oxide nanoparticles (ZnO-NPs) are well-known as a safe antibacterial agent.
34296596	4	41	theme	oxide	606:610	arg1	nanoparticles					612:624	Zinc oxide nanoparticles	601:624	Zinc oxide nanoparticles (ZnO-NPs)	601:634	Zinc oxide nanoparticles (ZnO-NPs) are well-known as a safe antibacterial agent.
34296596	9	42	theme	cells	1254:1258	arg1	proliferation					1226:1238	the proliferation	1222:1238	the proliferation of fibroblast cells	1222:1258	The cytotoxicity of the dressing toward L929 fibroblast cells clearly showed safety due to the proliferation of fibroblast cells.
34296596	2	43	theme	antibacterial	423:435	arg1	activity					437:444	antibacterial activity	423:444	antibacterial activity	423:444	The lack of antibacterial activity and healing-promoting ability are the main drawbacks that limit its wide application.
34296596	9	44	theme	dressing	1155:1162	arg1	cytotoxicity					1135:1146	The cytotoxicity	1131:1146	The cytotoxicity of the dressing toward L929 fibroblast cells	1131:1191	The cytotoxicity of the dressing toward L929 fibroblast cells clearly showed safety due to the proliferation of fibroblast cells.
34296596	0	45	theme	Nanocellulose	56:68	arg1	Functionalization					0:16	Functionalization	0:16	Functionalization of Aminoalkylsilane-Grafted Bacterial Nanocellulose with ZnO-NPs-Doped Pullulan Electrospun Nanofibers for Multifunctional Wound Dressing.	0:155	Functionalization of Aminoalkylsilane-Grafted Bacterial Nanocellulose with ZnO-NPs-Doped Pullulan Electrospun Nanofibers for Multifunctional Wound Dressing.
34296596	2	46	theme	ability	468:474	arg1	drawbacks					489:497	the main drawbacks	480:497	the main drawbacks that limit its wide application	480:529	The lack of antibacterial activity and healing-promoting ability are the main drawbacks that limit its wide application.
34296596	2	46	theme	ability	468:474	arg1	lack					415:418	The lack	411:418	The lack of antibacterial activity and healing-promoting ability	411:474	The lack of antibacterial activity and healing-promoting ability are the main drawbacks that limit its wide application.
34296596	1	47	theme	biomedical	353:362	arg1	dressings					400:408	wound dressings	394:408	especially wound dressings	383:408	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	1	47	theme	biomedical	353:362	arg1	production					371:380	biomedical device production	353:380	biomedical device production	353:380	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	1	48	from	absorption	281:290	arg1	state					226:230	a wet state	220:230	a wet state	220:230	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	6	49	theme	successful	876:885	arg1	production					887:896	the successful production	872:896	the successful production of A-g-BNC/Pul-ZnO	872:915	FTIR results confirmed the successful production of A-g-BNC/Pul-ZnO.
34296596	10	50	theme	vessel	1355:1360	arg1	formation					1362:1370	small blood vessel formation	1343:1370	small blood vessel formation	1343:1370	The animal test in a rat model indicated faster healing and re-epithelialization, small blood vessel formation, and collagen synthesis in the wounds covered by A-g-BNC/Pul-ZnO.
34296596	1	51	theme	moisture	162:169	arg1	permeability					171:182	High moisture permeability	157:182	High moisture permeability	157:182	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	2	52	theme	wide	514:517	arg1	application					519:529	its wide application	510:529	its wide application	510:529	The lack of antibacterial activity and healing-promoting ability are the main drawbacks that limit its wide application.
34296596	1	53	theme	device	364:369	arg1	dressings					400:408	wound dressings	394:408	especially wound dressings	383:408	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	1	53	theme	device	364:369	arg1	production					371:380	biomedical device production	353:380	biomedical device production	353:380	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	10	54	theme	blood	1349:1353	arg1	formation					1362:1370	small blood vessel formation	1343:1370	small blood vessel formation	1343:1370	The animal test in a rat model indicated faster healing and re-epithelialization, small blood vessel formation, and collagen synthesis in the wounds covered by A-g-BNC/Pul-ZnO.
34296596	7	55	theme	clotting	959:966	arg1	performance					968:978	blood clotting performance	953:978	blood clotting performance better than that of BNC	953:1002	The obtained dressing demonstrated blood clotting performance better than that of BNC.
34296596	0	56	with	Functionalization	0:16	arg1	Nanofibers					110:119	Nanofibers	110:119	Nanofibers	110:119	Functionalization of Aminoalkylsilane-Grafted Bacterial Nanocellulose with ZnO-NPs-Doped Pullulan Electrospun Nanofibers for Multifunctional Wound Dressing.
34296596	1	57	theme	high	268:271	arg1	absorption					281:290	high exudate absorption	268:290	high exudate absorption	268:290	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	1	58	from	capability	252:261	arg1	state					226:230	a wet state	220:230	a wet state	220:230	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	9	59	theme	L929	1171:1174	arg1	cells					1187:1191	L929 fibroblast cells	1171:1191	L929 fibroblast cells	1171:1191	The cytotoxicity of the dressing toward L929 fibroblast cells clearly showed safety due to the proliferation of fibroblast cells.
34296596	1	60	theme	excellent	185:193	arg1	properties					206:215	excellent mechanical properties	185:215	excellent mechanical properties in a wet state	185:230	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	1	61	theme	exudate	273:279	arg1	absorption					281:290	high exudate absorption	268:290	high exudate absorption	268:290	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	6	62	theme	FTIR	849:852	arg1	results					854:860	FTIR results	849:860	FTIR results	849:860	FTIR results confirmed the successful production of A-g-BNC/Pul-ZnO.
34296596	9	63	theme	fibroblast	1243:1252	arg1	cells					1254:1258	fibroblast cells	1243:1258	fibroblast cells	1243:1258	The cytotoxicity of the dressing toward L929 fibroblast cells clearly showed safety due to the proliferation of fibroblast cells.
34296596	2	64	theme	main	484:487	arg1	drawbacks					489:497	the main drawbacks	480:497	the main drawbacks that limit its wide application	480:529	The lack of antibacterial activity and healing-promoting ability are the main drawbacks that limit its wide application.
34296596	2	64	theme	main	484:487	arg1	lack					415:418	The lack	411:418	The lack of antibacterial activity and healing-promoting ability	411:474	The lack of antibacterial activity and healing-promoting ability are the main drawbacks that limit its wide application.
34296596	1	65	theme	mechanical	195:204	arg1	properties					206:215	excellent mechanical properties	185:215	excellent mechanical properties in a wet state	185:230	High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings.
34296596	7	66	theme	blood	953:957	arg1	performance					968:978	blood clotting performance	953:978	blood clotting performance better than that of BNC	953:1002	The obtained dressing demonstrated blood clotting performance better than that of BNC.
34296596	4	67	theme	safe	656:659	arg1	agent					675:679	a safe antibacterial agent	654:679	a safe antibacterial agent	654:679	Zinc oxide nanoparticles (ZnO-NPs) are well-known as a safe antibacterial agent.
34296596	8	68	dep	5	1093:1093	arg1	to					1090:1091	to	1090:1091	to	1090:1091	The dressing showed an ability to release ZnO, and its antibacterial activity was up to 5 log values higher than that of BNC.
34296596	9	69	theme	fibroblast	1176:1185	arg1	cells					1187:1191	L929 fibroblast cells	1171:1191	L929 fibroblast cells	1171:1191	The cytotoxicity of the dressing toward L929 fibroblast cells clearly showed safety due to the proliferation of fibroblast cells.
34296596	7	70	theme	obtained	922:929	arg1	dressing					931:938	The obtained dressing	918:938	The obtained dressing	918:938	The obtained dressing demonstrated blood clotting performance better than that of BNC.
33290651	11	0	theme	stimulation	2043:2053	arg1	properties					1996:2005	the anticoagulant properties	1978:2005	the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization	1978:2075	Thus, the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization suggest that it has great potential in clinical applications as a small-caliber artificial blood vessel.
33290651	7	1	theme	lumen	1483:1487	arg1	patency					1489:1495	lumen patency	1483:1495	lumen patency	1483:1495	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	11	2	theme	BNC-SFNP-Hep	2014:2025	arg1	conduit					2027:2033	the BNC-SFNP-Hep conduit	2010:2033	the BNC-SFNP-Hep conduit	2010:2033	Thus, the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization suggest that it has great potential in clinical applications as a small-caliber artificial blood vessel.
33290651	1	3	theme	anticoagulant	287:299	arg1	properties					301:310	its anticoagulant properties	283:310	its anticoagulant properties with more rapid endothelialization	283:345	Bacterial nanocellulose (BNC) is a promising material for small-caliber artificial blood vessels, although promoting its anticoagulant properties with more rapid endothelialization would improve long-term patency.
33290651	9	4	theme	BNC-SFNP	1728:1735	arg1	conduit					1737:1743	the BNC-SFNP conduit	1724:1743	the BNC-SFNP conduit causing the deepest infiltration	1724:1776	Autogenous tissues were observed around the conduits, and cells infiltrated into the edges of all samples, the BNC-SFNP conduit causing the deepest infiltration, providing an appropriate microenvironment for angiogenesis when used in small-caliber blood vessel applications.
33290651	9	4	theme	BNC-SFNP	1728:1735	arg1	edges					1702:1706	the edges	1698:1706	the edges of all samples	1698:1721	Autogenous tissues were observed around the conduits, and cells infiltrated into the edges of all samples, the BNC-SFNP conduit causing the deepest infiltration, providing an appropriate microenvironment for angiogenesis when used in small-caliber blood vessel applications.
33290651	7	5	theme	rapid	1444:1448	arg1	endothelialization					1450:1467	rapid endothelialization	1444:1467	rapid endothelialization	1444:1467	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	11	6	theme	artificial	2157:2166	arg1	vessel					2174:2179	a small-caliber artificial blood vessel	2141:2179	a small-caliber artificial blood vessel	2141:2179	Thus, the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization suggest that it has great potential in clinical applications as a small-caliber artificial blood vessel.
33290651	4	7	dep	Fourier	781:787	arg1	transform					789:797	transform	789:797	transform infrared spectroscopy	789:819	Fourier transform infrared spectroscopy confirmed the formation of SF-HepNPs, although they did not incorporate into the fibrillar network due to their large size.
33290651	9	8	theme	deepest	1757:1763	arg1	infiltration					1765:1776	the deepest infiltration	1753:1776	the deepest infiltration	1753:1776	Autogenous tissues were observed around the conduits, and cells infiltrated into the edges of all samples, the BNC-SFNP conduit causing the deepest infiltration, providing an appropriate microenvironment for angiogenesis when used in small-caliber blood vessel applications.
33290651	2	9	theme	luminal	439:445	arg1	surface					452:458	the luminal wall surface	435:458	the luminal wall surface of BNC conduits	435:474	Silk fibroin nanoparticles (SFNP) were introduced into the luminal wall surface of BNC conduits both with and without heparin (Hep) through pressurization followed by fixation.
33290651	0	10	theme	Small-Caliber	123:135	arg1	Applications					152:163	Small-Caliber Vascular Graft Applications	123:163	Small-Caliber Vascular Graft Applications	123:163	Improved Performance of Bacterial Nanocellulose Conduits by the Introduction of Silk Fibroin Nanoparticles and Heparin for Small-Caliber Vascular Graft Applications.
33290651	11	11	theme	blood	2168:2172	arg1	vessel					2174:2179	a small-caliber artificial blood vessel	2141:2179	a small-caliber artificial blood vessel	2141:2179	Thus, the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization suggest that it has great potential in clinical applications as a small-caliber artificial blood vessel.
33290651	7	12	theme	cell	1414:1417	arg1	proliferation					1419:1431	controlled excessive human arterial smooth muscle cell proliferation	1364:1431	human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation	1303:1431	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	0	13	theme	Graft	146:150	arg1	Applications					152:163	Small-Caliber Vascular Graft Applications	123:163	Small-Caliber Vascular Graft Applications	123:163	Improved Performance of Bacterial Nanocellulose Conduits by the Introduction of Silk Fibroin Nanoparticles and Heparin for Small-Caliber Vascular Graft Applications.
33290651	10	14	theme	inflammatory	1896:1907	arg1	cells					1909:1913	Few inflammatory cells	1892:1913	Few inflammatory cells	1892:1913	Few inflammatory cells were found around the BNC-Hep and BNC-SFNP-Hep conduits.
33290651	1	15	theme	small-caliber	224:236	arg1	vessels					255:261	small-caliber artificial blood vessels	224:261	small-caliber artificial blood vessels	224:261	Bacterial nanocellulose (BNC) is a promising material for small-caliber artificial blood vessels, although promoting its anticoagulant properties with more rapid endothelialization would improve long-term patency.
33290651	4	16	theme	fibrillar	902:910	arg1	network					912:918	the fibrillar network	898:918	the fibrillar network due to their large size	898:942	Fourier transform infrared spectroscopy confirmed the formation of SF-HepNPs, although they did not incorporate into the fibrillar network due to their large size.
33290651	8	17	theme	significant	1501:1511	arg1	reaction					1526:1533	No significant inflammatory reaction	1498:1533	No significant inflammatory reaction	1498:1533	No significant inflammatory reaction or material degradation was observed after subcutaneous implantation for 4 weeks.
33290651	7	18	theme	smooth	1400:1405	arg1	proliferation					1419:1431	controlled excessive human arterial smooth muscle cell proliferation	1364:1431	human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation	1303:1431	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	4	19	theme	due	920:922	arg1	network					912:918	the fibrillar network	898:918	the fibrillar network due to their large size	898:942	Fourier transform infrared spectroscopy confirmed the formation of SF-HepNPs, although they did not incorporate into the fibrillar network due to their large size.
33290651	7	20	theme	human	1385:1389	arg1	proliferation					1419:1431	controlled excessive human arterial smooth muscle cell proliferation	1364:1431	human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation	1303:1431	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	5	21	dep	grafted	966:972	arg1	verified					997:1004	verified	997:1004	verified by toluidine blue staining	997:1031	Hep was successfully grafted onto BNC and BNC-SFNP, verified by toluidine blue staining.
33290651	11	22	theme	great	2097:2101	arg1	potential					2103:2111	great potential	2097:2111	great potential	2097:2111	Thus, the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization suggest that it has great potential in clinical applications as a small-caliber artificial blood vessel.
33290651	8	23	theme	material	1538:1545	arg1	degradation					1547:1557	material degradation	1538:1557	material degradation	1538:1557	No significant inflammatory reaction or material degradation was observed after subcutaneous implantation for 4 weeks.
33290651	7	24	theme	controlled	1364:1373	arg1	proliferation					1419:1431	controlled excessive human arterial smooth muscle cell proliferation	1364:1431	human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation	1303:1431	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	1	25	theme	Bacterial	166:174	arg1	material					211:218	a promising material	199:218	a promising material for small-caliber artificial blood vessels	199:261	Bacterial nanocellulose (BNC) is a promising material for small-caliber artificial blood vessels, although promoting its anticoagulant properties with more rapid endothelialization would improve long-term patency.
33290651	1	25	theme	Bacterial	166:174	arg1	BNC					191:193	BNC	191:193	BNC	191:193	Bacterial nanocellulose (BNC) is a promising material for small-caliber artificial blood vessels, although promoting its anticoagulant properties with more rapid endothelialization would improve long-term patency.
33290651	1	25	theme	Bacterial	166:174	arg1	nanocellulose					176:188	Bacterial nanocellulose	166:188	Bacterial nanocellulose (BNC)	166:194	Bacterial nanocellulose (BNC) is a promising material for small-caliber artificial blood vessels, although promoting its anticoagulant properties with more rapid endothelialization would improve long-term patency.
33290651	0	26	theme	Silk	80:83	arg1	Nanoparticles					93:105	Silk Fibroin Nanoparticles	80:105	Silk Fibroin Nanoparticles	80:105	Improved Performance of Bacterial Nanocellulose Conduits by the Introduction of Silk Fibroin Nanoparticles and Heparin for Small-Caliber Vascular Graft Applications.
33290651	9	27	theme	small-caliber	1851:1863	arg1	applications					1878:1889	small-caliber blood vessel applications	1851:1889	small-caliber blood vessel applications	1851:1889	Autogenous tissues were observed around the conduits, and cells infiltrated into the edges of all samples, the BNC-SFNP conduit causing the deepest infiltration, providing an appropriate microenvironment for angiogenesis when used in small-caliber blood vessel applications.
33290651	0	28	theme	Nanoparticles	93:105	arg1	Introduction					64:75	the Introduction	60:75	the Introduction of Silk Fibroin Nanoparticles	60:105	Improved Performance of Bacterial Nanocellulose Conduits by the Introduction of Silk Fibroin Nanoparticles and Heparin for Small-Caliber Vascular Graft Applications.
33290651	0	28	theme	Nanoparticles	93:105	arg1	Heparin					111:117	Heparin	111:117	Heparin for Small-Caliber Vascular Graft Applications	111:163	Improved Performance of Bacterial Nanocellulose Conduits by the Introduction of Silk Fibroin Nanoparticles and Heparin for Small-Caliber Vascular Graft Applications.
33290651	9	29	theme	Autogenous	1617:1626	arg1	tissues					1628:1634	Autogenous tissues	1617:1634	Autogenous tissues	1617:1634	Autogenous tissues were observed around the conduits, and cells infiltrated into the edges of all samples, the BNC-SFNP conduit causing the deepest infiltration, providing an appropriate microenvironment for angiogenesis when used in small-caliber blood vessel applications.
33290651	9	30	theme	vessel	1871:1876	arg1	applications					1878:1889	small-caliber blood vessel applications	1851:1889	small-caliber blood vessel applications	1851:1889	Autogenous tissues were observed around the conduits, and cells infiltrated into the edges of all samples, the BNC-SFNP conduit causing the deepest infiltration, providing an appropriate microenvironment for angiogenesis when used in small-caliber blood vessel applications.
33290651	7	31	dep	promoted	1294:1301	arg1	improving					1473:1481	improving	1473:1481	improving lumen patency	1473:1495	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	7	31	dep	promoted	1294:1301	arg1	assisting					1434:1442	assisting	1434:1442	assisting rapid endothelialization	1434:1467	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	11	32	theme	anticoagulant	1982:1994	arg1	properties					1996:2005	the anticoagulant properties	1978:2005	the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization	1978:2075	Thus, the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization suggest that it has great potential in clinical applications as a small-caliber artificial blood vessel.
33290651	2	33	theme	conduits	467:474	arg1	surface					452:458	the luminal wall surface	435:458	the luminal wall surface of BNC conduits	435:474	Silk fibroin nanoparticles (SFNP) were introduced into the luminal wall surface of BNC conduits both with and without heparin (Hep) through pressurization followed by fixation.
33290651	6	34	dep	samples	1090:1096	arg1	BNC-SF-HepNP					1114:1125	BNC-SF-HepNP	1114:1125	BNC-SF-HepNP	1114:1125	The hemocompatibility and cytocompatibility of the five samples (BNC, BNC-SFNP, BNC-SF-HepNP, BNC-Hep, and BNC-SFNP-Hep conduits) were compared in vitro.
33290651	6	34	dep	samples	1090:1096	arg1	BNC-Hep					1128:1134	BNC-Hep	1128:1134	BNC-Hep	1128:1134	The hemocompatibility and cytocompatibility of the five samples (BNC, BNC-SFNP, BNC-SF-HepNP, BNC-Hep, and BNC-SFNP-Hep conduits) were compared in vitro.
33290651	6	34	dep	samples	1090:1096	arg1	BNC					1099:1101	BNC	1099:1101	BNC	1099:1101	The hemocompatibility and cytocompatibility of the five samples (BNC, BNC-SFNP, BNC-SF-HepNP, BNC-Hep, and BNC-SFNP-Hep conduits) were compared in vitro.
33290651	6	34	dep	samples	1090:1096	arg1	BNC-SFNP					1104:1111	BNC-SFNP	1104:1111	BNC-SFNP	1104:1111	The hemocompatibility and cytocompatibility of the five samples (BNC, BNC-SFNP, BNC-SF-HepNP, BNC-Hep, and BNC-SFNP-Hep conduits) were compared in vitro.
33290651	6	34	dep	samples	1090:1096	arg1	conduits					1154:1161	BNC-SFNP-Hep conduits	1141:1161	BNC-SFNP-Hep conduits	1141:1161	The hemocompatibility and cytocompatibility of the five samples (BNC, BNC-SFNP, BNC-SF-HepNP, BNC-Hep, and BNC-SFNP-Hep conduits) were compared in vitro.
33290651	6	34	dep	samples	1090:1096	arg1	samples					1090:1096	the five samples	1081:1096	the five samples (BNC, BNC-SFNP, BNC-SF-HepNP, BNC-Hep, and BNC-SFNP-Hep conduits)	1081:1162	The hemocompatibility and cytocompatibility of the five samples (BNC, BNC-SFNP, BNC-SF-HepNP, BNC-Hep, and BNC-SFNP-Hep conduits) were compared in vitro.
33290651	7	35	theme	endothelial	1324:1334	arg1	proliferation					1341:1353	human umbilical vein endothelial cell proliferation	1303:1353	human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation	1303:1431	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	10	36	theme	BNC-SFNP-Hep	1949:1960	arg1	conduits					1962:1969	the BNC-Hep and BNC-SFNP-Hep conduits	1933:1969	the BNC-Hep and BNC-SFNP-Hep conduits	1933:1969	Few inflammatory cells were found around the BNC-Hep and BNC-SFNP-Hep conduits.
33290651	2	37	theme	wall	447:450	arg1	surface					452:458	the luminal wall surface	435:458	the luminal wall surface of BNC conduits	435:474	Silk fibroin nanoparticles (SFNP) were introduced into the luminal wall surface of BNC conduits both with and without heparin (Hep) through pressurization followed by fixation.
33290651	0	38	theme	Nanocellulose	34:46	arg1	Conduits					48:55	Bacterial Nanocellulose Conduits	24:55	Bacterial Nanocellulose Conduits	24:55	Improved Performance of Bacterial Nanocellulose Conduits by the Introduction of Silk Fibroin Nanoparticles and Heparin for Small-Caliber Vascular Graft Applications.
33290651	3	39	dep	grafted	708:714	arg1	2					694:694	2	694:694	2	694:694	Hep was introduced in two ways: (1) embedded within SF nanoparticles to form SF-HepNPs for construction of the BNC-SF-HepNP conduit and (2) chemically grafted onto BNC and BNC-SFNP to form BNC-Hep and BNC-SFNP-Hep conduits.
33290651	5	40	theme	blue	1019:1022	arg1	staining					1024:1031	toluidine blue staining	1009:1031	toluidine blue staining	1009:1031	Hep was successfully grafted onto BNC and BNC-SFNP, verified by toluidine blue staining.
33290651	7	41	theme	umbilical	1309:1317	arg1	proliferation					1341:1353	human umbilical vein endothelial cell proliferation	1303:1353	human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation	1303:1431	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	10	42	theme	BNC-Hep	1937:1943	arg1	conduits					1962:1969	the BNC-Hep and BNC-SFNP-Hep conduits	1933:1969	the BNC-Hep and BNC-SFNP-Hep conduits	1933:1969	Few inflammatory cells were found around the BNC-Hep and BNC-SFNP-Hep conduits.
33290651	2	43	theme	fibroin	385:391	arg1	SFNP					408:411	SFNP	408:411	SFNP	408:411	Silk fibroin nanoparticles (SFNP) were introduced into the luminal wall surface of BNC conduits both with and without heparin (Hep) through pressurization followed by fixation.
33290651	2	43	theme	fibroin	385:391	arg1	nanoparticles					393:405	Silk fibroin nanoparticles	380:405	Silk fibroin nanoparticles (SFNP)	380:412	Silk fibroin nanoparticles (SFNP) were introduced into the luminal wall surface of BNC conduits both with and without heparin (Hep) through pressurization followed by fixation.
33290651	1	44	theme	artificial	238:247	arg1	vessels					255:261	small-caliber artificial blood vessels	224:261	small-caliber artificial blood vessels	224:261	Bacterial nanocellulose (BNC) is a promising material for small-caliber artificial blood vessels, although promoting its anticoagulant properties with more rapid endothelialization would improve long-term patency.
33290651	3	45	theme	BNC-SF-HepNP	668:679	arg1	conduit					681:687	the BNC-SF-HepNP conduit	664:687	the BNC-SF-HepNP conduit	664:687	Hep was introduced in two ways: (1) embedded within SF nanoparticles to form SF-HepNPs for construction of the BNC-SF-HepNP conduit and (2) chemically grafted onto BNC and BNC-SFNP to form BNC-Hep and BNC-SFNP-Hep conduits.
33290651	7	46	theme	BNC-Hep	1204:1210	arg1	conduits					1229:1236	The heparinized BNC-Hep and BNC-SFNP-Hep conduits	1188:1236	The heparinized BNC-Hep and BNC-SFNP-Hep conduits	1188:1236	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	9	47	theme	samples	1715:1721	arg1	conduit					1737:1743	the BNC-SFNP conduit	1724:1743	the BNC-SFNP conduit causing the deepest infiltration	1724:1776	Autogenous tissues were observed around the conduits, and cells infiltrated into the edges of all samples, the BNC-SFNP conduit causing the deepest infiltration, providing an appropriate microenvironment for angiogenesis when used in small-caliber blood vessel applications.
33290651	9	47	theme	samples	1715:1721	arg1	edges					1702:1706	the edges	1698:1706	the edges of all samples	1698:1721	Autogenous tissues were observed around the conduits, and cells infiltrated into the edges of all samples, the BNC-SFNP conduit causing the deepest infiltration, providing an appropriate microenvironment for angiogenesis when used in small-caliber blood vessel applications.
33290651	11	48	theme	clinical	2116:2123	arg1	applications					2125:2136	clinical applications	2116:2136	clinical applications as a small-caliber artificial blood vessel	2116:2179	Thus, the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization suggest that it has great potential in clinical applications as a small-caliber artificial blood vessel.
33290651	4	49	theme	SF-HepNPs	848:856	arg1	formation					835:843	the formation	831:843	the formation of SF-HepNPs	831:856	Fourier transform infrared spectroscopy confirmed the formation of SF-HepNPs, although they did not incorporate into the fibrillar network due to their large size.
33290651	11	50	theme	small-caliber	2143:2155	arg1	vessel					2174:2179	a small-caliber artificial blood vessel	2141:2179	a small-caliber artificial blood vessel	2141:2179	Thus, the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization suggest that it has great potential in clinical applications as a small-caliber artificial blood vessel.
33290651	4	51	dep	transform	789:797	arg1	infrared					799:806	infrared	799:806	transform infrared spectroscopy	789:819	Fourier transform infrared spectroscopy confirmed the formation of SF-HepNPs, although they did not incorporate into the fibrillar network due to their large size.
33290651	1	52	with	properties	301:310	arg1	endothelialization					328:345	more rapid endothelialization	317:345	more rapid endothelialization	317:345	Bacterial nanocellulose (BNC) is a promising material for small-caliber artificial blood vessels, although promoting its anticoagulant properties with more rapid endothelialization would improve long-term patency.
33290651	6	53	theme	BNC-SFNP-Hep	1141:1152	arg1	conduits					1154:1161	BNC-SFNP-Hep conduits	1141:1161	BNC-SFNP-Hep conduits	1141:1161	The hemocompatibility and cytocompatibility of the five samples (BNC, BNC-SFNP, BNC-SF-HepNP, BNC-Hep, and BNC-SFNP-Hep conduits) were compared in vitro.
33290651	3	54	theme	BNC-Hep	746:752	arg1	conduits					771:778	BNC-Hep and BNC-SFNP-Hep conduits	746:778	BNC-Hep and BNC-SFNP-Hep conduits	746:778	Hep was introduced in two ways: (1) embedded within SF nanoparticles to form SF-HepNPs for construction of the BNC-SF-HepNP conduit and (2) chemically grafted onto BNC and BNC-SFNP to form BNC-Hep and BNC-SFNP-Hep conduits.
33290651	0	55	theme	Vascular	137:144	arg1	Applications					152:163	Small-Caliber Vascular Graft Applications	123:163	Small-Caliber Vascular Graft Applications	123:163	Improved Performance of Bacterial Nanocellulose Conduits by the Introduction of Silk Fibroin Nanoparticles and Heparin for Small-Caliber Vascular Graft Applications.
33290651	1	56	theme	promising	201:209	arg1	material					211:218	a promising material	199:218	a promising material for small-caliber artificial blood vessels	199:261	Bacterial nanocellulose (BNC) is a promising material for small-caliber artificial blood vessels, although promoting its anticoagulant properties with more rapid endothelialization would improve long-term patency.
33290651	1	56	theme	promising	201:209	arg1	nanocellulose					176:188	Bacterial nanocellulose	166:188	Bacterial nanocellulose (BNC)	166:194	Bacterial nanocellulose (BNC) is a promising material for small-caliber artificial blood vessels, although promoting its anticoagulant properties with more rapid endothelialization would improve long-term patency.
33290651	11	57	contain	has	2093:2095	arg1	it					2090:2091	it	2090:2091	it	2090:2091	Thus, the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization suggest that it has great potential in clinical applications as a small-caliber artificial blood vessel.
33290651	11	57	contain	has	2093:2095	arg2	potential					2103:2111	great potential	2097:2111	great potential	2097:2111	Thus, the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization suggest that it has great potential in clinical applications as a small-caliber artificial blood vessel.
33290651	3	58	theme	embedded	593:600	arg1	nanoparticles					612:624	embedded within SF nanoparticles	593:624	embedded within SF nanoparticles	593:624	Hep was introduced in two ways: (1) embedded within SF nanoparticles to form SF-HepNPs for construction of the BNC-SF-HepNP conduit and (2) chemically grafted onto BNC and BNC-SFNP to form BNC-Hep and BNC-SFNP-Hep conduits.
33290651	4	59	theme	large	933:937	arg1	size					939:942	their large size	927:942	their large size	927:942	Fourier transform infrared spectroscopy confirmed the formation of SF-HepNPs, although they did not incorporate into the fibrillar network due to their large size.
33290651	8	60	theme	inflammatory	1513:1524	arg1	reaction					1526:1533	No significant inflammatory reaction	1498:1533	No significant inflammatory reaction	1498:1533	No significant inflammatory reaction or material degradation was observed after subcutaneous implantation for 4 weeks.
33290651	10	61	theme	Few	1892:1894	arg1	cells					1909:1913	Few inflammatory cells	1892:1913	Few inflammatory cells	1892:1913	Few inflammatory cells were found around the BNC-Hep and BNC-SFNP-Hep conduits.
33290651	9	62	theme	appropriate	1792:1802	arg1	microenvironment					1804:1819	an appropriate microenvironment	1789:1819	an appropriate microenvironment for angiogenesis when used in small-caliber blood vessel applications	1789:1889	Autogenous tissues were observed around the conduits, and cells infiltrated into the edges of all samples, the BNC-SFNP conduit causing the deepest infiltration, providing an appropriate microenvironment for angiogenesis when used in small-caliber blood vessel applications.
33290651	7	63	theme	muscle	1407:1412	arg1	proliferation					1419:1431	controlled excessive human arterial smooth muscle cell proliferation	1364:1431	human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation	1303:1431	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	3	64	theme	BNC-SFNP-Hep	758:769	arg1	conduits					771:778	BNC-Hep and BNC-SFNP-Hep conduits	746:778	BNC-Hep and BNC-SFNP-Hep conduits	746:778	Hep was introduced in two ways: (1) embedded within SF nanoparticles to form SF-HepNPs for construction of the BNC-SF-HepNP conduit and (2) chemically grafted onto BNC and BNC-SFNP to form BNC-Hep and BNC-SFNP-Hep conduits.
33290651	7	65	theme	arterial	1391:1398	arg1	proliferation					1419:1431	controlled excessive human arterial smooth muscle cell proliferation	1364:1431	human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation	1303:1431	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	7	66	theme	BNC-SFNP-Hep	1216:1227	arg1	conduits					1229:1236	The heparinized BNC-Hep and BNC-SFNP-Hep conduits	1188:1236	The heparinized BNC-Hep and BNC-SFNP-Hep conduits	1188:1236	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	7	67	theme	excessive	1375:1383	arg1	proliferation					1419:1431	controlled excessive human arterial smooth muscle cell proliferation	1364:1431	human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation	1303:1431	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	7	68	theme	heparinized	1192:1202	arg1	conduits					1229:1236	The heparinized BNC-Hep and BNC-SFNP-Hep conduits	1188:1236	The heparinized BNC-Hep and BNC-SFNP-Hep conduits	1188:1236	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	0	69	theme	Fibroin	85:91	arg1	Nanoparticles					93:105	Silk Fibroin Nanoparticles	80:105	Silk Fibroin Nanoparticles	80:105	Improved Performance of Bacterial Nanocellulose Conduits by the Introduction of Silk Fibroin Nanoparticles and Heparin for Small-Caliber Vascular Graft Applications.
33290651	8	70	theme	subcutaneous	1578:1589	arg1	implantation					1591:1602	subcutaneous implantation	1578:1602	subcutaneous implantation	1578:1602	No significant inflammatory reaction or material degradation was observed after subcutaneous implantation for 4 weeks.
33290651	9	71	theme	blood	1865:1869	arg1	applications					1878:1889	small-caliber blood vessel applications	1851:1889	small-caliber blood vessel applications	1851:1889	Autogenous tissues were observed around the conduits, and cells infiltrated into the edges of all samples, the BNC-SFNP conduit causing the deepest infiltration, providing an appropriate microenvironment for angiogenesis when used in small-caliber blood vessel applications.
33290651	6	72	theme	samples	1090:1096	arg1	cytocompatibility					1060:1076	cytocompatibility	1060:1076	cytocompatibility	1060:1076	The hemocompatibility and cytocompatibility of the five samples (BNC, BNC-SFNP, BNC-SF-HepNP, BNC-Hep, and BNC-SFNP-Hep conduits) were compared in vitro.
33290651	6	72	theme	samples	1090:1096	arg1	hemocompatibility					1038:1054	hemocompatibility	1038:1054	hemocompatibility	1038:1054	The hemocompatibility and cytocompatibility of the five samples (BNC, BNC-SFNP, BNC-SF-HepNP, BNC-Hep, and BNC-SFNP-Hep conduits) were compared in vitro.
33290651	7	73	theme	cell	1336:1339	arg1	proliferation					1341:1353	human umbilical vein endothelial cell proliferation	1303:1353	human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation	1303:1431	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	0	74	theme	Bacterial	24:32	arg1	Conduits					48:55	Bacterial Nanocellulose Conduits	24:55	Bacterial Nanocellulose Conduits	24:55	Improved Performance of Bacterial Nanocellulose Conduits by the Introduction of Silk Fibroin Nanoparticles and Heparin for Small-Caliber Vascular Graft Applications.
33290651	11	75	theme	endothelialization	2058:2075	arg1	conduit					2027:2033	the BNC-SFNP-Hep conduit	2010:2033	the BNC-SFNP-Hep conduit	2010:2033	Thus, the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization suggest that it has great potential in clinical applications as a small-caliber artificial blood vessel.
33290651	11	75	theme	endothelialization	2058:2075	arg1	stimulation					2043:2053	its stimulation	2039:2053	its stimulation of endothelialization	2039:2075	Thus, the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization suggest that it has great potential in clinical applications as a small-caliber artificial blood vessel.
33290651	7	76	theme	vein	1319:1322	arg1	proliferation					1341:1353	human umbilical vein endothelial cell proliferation	1303:1353	human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation	1303:1431	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	2	77	theme	BNC	463:465	arg1	conduits					467:474	BNC conduits	463:474	BNC conduits	463:474	Silk fibroin nanoparticles (SFNP) were introduced into the luminal wall surface of BNC conduits both with and without heparin (Hep) through pressurization followed by fixation.
33290651	0	78	theme	Conduits	48:55	arg1	Performance					9:19	Performance	9:19	Performance of Bacterial Nanocellulose Conduits	9:55	Improved Performance of Bacterial Nanocellulose Conduits by the Introduction of Silk Fibroin Nanoparticles and Heparin for Small-Caliber Vascular Graft Applications.
33290651	1	79	theme	rapid	322:326	arg1	endothelialization					328:345	more rapid endothelialization	317:345	more rapid endothelialization	317:345	Bacterial nanocellulose (BNC) is a promising material for small-caliber artificial blood vessels, although promoting its anticoagulant properties with more rapid endothelialization would improve long-term patency.
33290651	7	80	theme	human	1303:1307	arg1	proliferation					1341:1353	human umbilical vein endothelial cell proliferation	1303:1353	human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation	1303:1431	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
33290651	11	81	theme	conduit	2027:2033	arg1	properties					1996:2005	the anticoagulant properties	1978:2005	the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization	1978:2075	Thus, the anticoagulant properties of the BNC-SFNP-Hep conduit and its stimulation of endothelialization suggest that it has great potential in clinical applications as a small-caliber artificial blood vessel.
33290651	3	82	theme	conduit	681:687	arg1	construction					648:659	construction	648:659	construction of the BNC-SF-HepNP conduit	648:687	Hep was introduced in two ways: (1) embedded within SF nanoparticles to form SF-HepNPs for construction of the BNC-SF-HepNP conduit and (2) chemically grafted onto BNC and BNC-SFNP to form BNC-Hep and BNC-SFNP-Hep conduits.
33290651	2	83	dep	surface	452:458	arg1	both					476:479	both	476:479	both	476:479	Silk fibroin nanoparticles (SFNP) were introduced into the luminal wall surface of BNC conduits both with and without heparin (Hep) through pressurization followed by fixation.
33290651	2	84	theme	Silk	380:383	arg1	SFNP					408:411	SFNP	408:411	SFNP	408:411	Silk fibroin nanoparticles (SFNP) were introduced into the luminal wall surface of BNC conduits both with and without heparin (Hep) through pressurization followed by fixation.
33290651	2	84	theme	Silk	380:383	arg1	nanoparticles					393:405	Silk fibroin nanoparticles	380:405	Silk fibroin nanoparticles (SFNP)	380:412	Silk fibroin nanoparticles (SFNP) were introduced into the luminal wall surface of BNC conduits both with and without heparin (Hep) through pressurization followed by fixation.
33290651	1	85	theme	long-term	361:369	arg1	patency					371:377	long-term patency	361:377	long-term patency	361:377	Bacterial nanocellulose (BNC) is a promising material for small-caliber artificial blood vessels, although promoting its anticoagulant properties with more rapid endothelialization would improve long-term patency.
33290651	1	86	theme	blood	249:253	arg1	vessels					255:261	small-caliber artificial blood vessels	224:261	small-caliber artificial blood vessels	224:261	Bacterial nanocellulose (BNC) is a promising material for small-caliber artificial blood vessels, although promoting its anticoagulant properties with more rapid endothelialization would improve long-term patency.
33290651	3	87	dep	form	629:632	arg1	1					590:590	1	590:590	1	590:590	Hep was introduced in two ways: (1) embedded within SF nanoparticles to form SF-HepNPs for construction of the BNC-SF-HepNP conduit and (2) chemically grafted onto BNC and BNC-SFNP to form BNC-Hep and BNC-SFNP-Hep conduits.
33290651	7	88	theme	anticoagulant	1251:1263	arg1	properties					1265:1274	the anticoagulant properties	1247:1274	the anticoagulant properties	1247:1274	The heparinized BNC-Hep and BNC-SFNP-Hep conduits improved the anticoagulant properties, and BNC-SFNP-Hep promoted human umbilical vein endothelial cell proliferation but also controlled excessive human arterial smooth muscle cell proliferation, assisting rapid endothelialization and improving lumen patency.
31954789	4	0	theme	collagen	511:518	arg1	chitosan					501:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	4	0	theme	collagen	511:518	arg1	peptide					520:526	collagen peptide	511:526	collagen peptide	511:526	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	6	1	theme	chitosan	729:736	arg1	konjac					777:782	oxidized konjac	768:782	oxidized konjac	768:782	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	6	1	theme	chitosan	729:736	arg1	/OKGM					761:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM	709:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels	709:793	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	8	2	from	application	1079:1089	arg1	field					1109:1113	wound dressing field	1094:1113	wound dressing field	1094:1113	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
31954789	8	3	theme	dressing	1100:1107	arg1	field					1109:1113	wound dressing field	1094:1113	wound dressing field	1094:1113	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
31954789	4	4	theme	oxidized	532:539	arg1	chitosan					501:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	4	4	theme	oxidized	532:539	arg1	konjac					541:546	oxidized konjac	532:546	oxidized konjac	532:546	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	4	5	theme	composite	459:467	arg1	chitosan					501:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	4	5	theme	composite	459:467	arg1	peptide					520:526	collagen peptide	511:526	collagen peptide	511:526	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	4	5	theme	composite	459:467	arg1	konjac					541:546	oxidized konjac	532:546	oxidized konjac	532:546	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	2	6	contain	have	289:292	arg1	Hydrogels					225:233	Hydrogels	225:233	Hydrogels	225:233	Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water.
31954789	2	6	contain	have	289:292	arg2	space					314:318	a three-dimensional space	294:318	a three-dimensional space	294:318	Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water.
31954789	2	6	contain	have	289:292	arg1	aggregates					239:248	aggregates	239:248	aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water	239:356	Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water.
31954789	4	7	theme	carboxymethyl	487:499	arg1	chitosan					501:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	4	7	theme	carboxymethyl	487:499	arg1	peptide					520:526	collagen peptide	511:526	collagen peptide	511:526	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	4	7	theme	carboxymethyl	487:499	arg1	konjac					541:546	oxidized konjac	532:546	oxidized konjac	532:546	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	5	8	theme	different	668:676	arg1	proportions					678:688	different proportions	668:688	different proportions	668:688	Then, we set up different hydrogels and tested hydrogels with different proportions.
31954789	7	9	theme	cells	911:915	arg1	growth					885:890	the growth	881:890	the growth of NS-FB and HS-FB cells	881:915	The effects of hydrogels on the growth of NS-FB and HS-FB cells were studied in vitro.
31954789	6	10	theme	carboxymethyl	715:727	arg1	konjac					777:782	oxidized konjac	768:782	oxidized konjac	768:782	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	6	10	theme	carboxymethyl	715:727	arg1	/OKGM					761:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM	709:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels	709:793	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	8	11	contain	has	1065:1067	arg2	application					1079:1089	potential application	1069:1089	potential application in wound dressing field	1069:1113	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
31954789	8	11	contain	has	1065:1067	arg1	hydrogel					991:998	the composite hydrogel	977:998	the composite hydrogel	977:998	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
31954789	4	12	theme	combined	478:485	arg1	chitosan					501:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	4	12	theme	combined	478:485	arg1	peptide					520:526	collagen peptide	511:526	collagen peptide	511:526	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	4	12	theme	combined	478:485	arg1	konjac					541:546	oxidized konjac	532:546	oxidized konjac	532:546	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	8	13	theme	excellent	1004:1012	arg1	properties					1025:1034	excellent mechanical properties	1004:1034	excellent mechanical properties	1004:1034	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
31954789	1	14	from	factors	177:183	arg1	skin					158:161	damaged skin	150:161	damaged skin from external factors	150:183	Medical dressings are used to protect damaged skin from external factors and provide a good healing environment.
31954789	7	15	from	effects	857:863	arg1	growth					885:890	the growth	881:890	the growth of NS-FB and HS-FB cells	881:915	The effects of hydrogels on the growth of NS-FB and HS-FB cells were studied in vitro.
31954789	8	16	contain	has	1000:1002	arg2	properties					1025:1034	excellent mechanical properties	1004:1034	excellent mechanical properties	1004:1034	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
31954789	8	16	contain	has	1000:1002	arg1	hydrogel					991:998	the composite hydrogel	977:998	the composite hydrogel	977:998	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
31954789	8	16	contain	has	1000:1002	arg2	activity					1051:1058	biological activity	1040:1058	biological activity	1040:1058	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
31954789	5	17	theme	different	622:630	arg1	hydrogels					632:640	different hydrogels	622:640	different hydrogels	622:640	Then, we set up different hydrogels and tested hydrogels with different proportions.
31954789	6	18	theme	X-ray	826:830	arg1	diffraction					832:842	X-ray diffraction	826:842	X-ray diffraction	826:842	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	2	19	theme	three-dimensional	296:312	arg1	space					314:318	a three-dimensional space	294:318	a three-dimensional space	294:318	Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water.
31954789	6	20	theme	CMCS	709:712	arg1	konjac					777:782	oxidized konjac	768:782	oxidized konjac	768:782	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	6	20	theme	CMCS	709:712	arg1	/OKGM					761:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM	709:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels	709:793	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	1	21	theme	good	199:202	arg1	environment					212:222	a good healing environment	197:222	a good healing environment	197:222	Medical dressings are used to protect damaged skin from external factors and provide a good healing environment.
31954789	8	22	theme	composite	981:989	arg1	hydrogel					991:998	the composite hydrogel	977:998	the composite hydrogel	977:998	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
31954789	7	23	theme	HS-FB	905:909	arg1	cells					911:915	NS-FB and HS-FB cells	895:915	NS-FB and HS-FB cells	895:915	The effects of hydrogels on the growth of NS-FB and HS-FB cells were studied in vitro.
31954789	1	24	theme	healing	204:210	arg1	environment					212:222	a good healing environment	197:222	a good healing environment	197:222	Medical dressings are used to protect damaged skin from external factors and provide a good healing environment.
31954789	3	25	theme	biomedical	402:411	arg1	materials					413:421	biomedical materials	402:421	biomedical materials	402:421	It has been widely studied in the field of biomedical materials.
31954789	8	26	theme	mechanical	1014:1023	arg1	properties					1025:1034	excellent mechanical properties	1004:1034	excellent mechanical properties	1004:1034	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
31954789	6	27	theme	oxidized	768:775	arg1	konjac					777:782	oxidized konjac	768:782	oxidized konjac	768:782	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	6	27	theme	oxidized	768:775	arg1	/OKGM					761:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM	709:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels	709:793	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	4	28	dep	chitosan	501:508	arg1	shown					579:583	shown	579:583	have been shown to be biocompatible	569:603	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	8	29	theme	biological	1040:1049	arg1	activity					1051:1058	biological activity	1040:1058	biological activity	1040:1058	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
31954789	6	30	theme	hydrogels	785:793	arg1	structures					695:704	The structures	691:704	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels	691:793	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	2	31	theme	large	335:339	arg1	water					352:356	water	352:356	water	352:356	Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water.
31954789	2	31	theme	large	335:339	arg1	amounts					341:347	large amounts	335:347	large amounts of water	335:356	Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water.
31954789	8	32	theme	tests	961:965	arg1	results					944:950	The results	940:950	The results of these tests	940:965	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
31954789	4	33	theme	novel	453:457	arg1	chitosan					501:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	4	33	theme	novel	453:457	arg1	peptide					520:526	collagen peptide	511:526	collagen peptide	511:526	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	4	33	theme	novel	453:457	arg1	konjac					541:546	oxidized konjac	532:546	oxidized konjac	532:546	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	5	34	with	hydrogels	653:661	arg1	proportions					678:688	different proportions	668:688	different proportions	668:688	Then, we set up different hydrogels and tested hydrogels with different proportions.
31954789	0	35	theme	chitosan/collagen	50:66	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of carboxymethyl chitosan/collagen peptide/oxidized konjac composite hydrogel.
31954789	0	35	theme	chitosan/collagen	50:66	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of carboxymethyl chitosan/collagen peptide/oxidized konjac composite hydrogel.
31954789	1	36	theme	damaged	150:156	arg1	skin					158:161	damaged skin	150:161	damaged skin from external factors	150:183	Medical dressings are used to protect damaged skin from external factors and provide a good healing environment.
31954789	0	37	theme	carboxymethyl	36:48	arg1	chitosan/collagen					50:66	carboxymethyl chitosan/collagen	36:66	carboxymethyl chitosan/collagen	36:66	Preparation and characterization of carboxymethyl chitosan/collagen peptide/oxidized konjac composite hydrogel.
31954789	4	38	theme	hydrogel	469:476	arg1	chitosan					501:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	a novel composite hydrogel combined carboxymethyl chitosan	451:508	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	4	38	theme	hydrogel	469:476	arg1	peptide					520:526	collagen peptide	511:526	collagen peptide	511:526	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	4	38	theme	hydrogel	469:476	arg1	konjac					541:546	oxidized konjac	532:546	oxidized konjac	532:546	In this study, we prepared a novel composite hydrogel combined carboxymethyl chitosan, collagen peptide and oxidized konjac, all three materials have been shown to be biocompatible.
31954789	2	39	theme	polymers	265:272	arg1	Hydrogels					225:233	Hydrogels	225:233	Hydrogels	225:233	Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water.
31954789	2	39	theme	polymers	265:272	arg1	aggregates					239:248	aggregates	239:248	aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water	239:356	Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water.
31954789	6	40	theme	/OKGM	761:765	arg1	hydrogels					785:793	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels	709:793	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels	709:793	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	3	41	theme	materials	413:421	arg1	field					393:397	the field	389:397	the field of biomedical materials	389:421	It has been widely studied in the field of biomedical materials.
31954789	0	42	theme	composite	92:100	arg1	hydrogel					102:109	konjac composite hydrogel	85:109	konjac composite hydrogel	85:109	Preparation and characterization of carboxymethyl chitosan/collagen peptide/oxidized konjac composite hydrogel.
31954789	2	43	theme	hydrophilic	253:263	arg1	polymers					265:272	hydrophilic polymers	253:272	hydrophilic polymers	253:272	Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water.
31954789	6	44	theme	peptide	753:759	arg1	konjac					777:782	oxidized konjac	768:782	oxidized konjac	768:782	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	6	44	theme	peptide	753:759	arg1	/OKGM					761:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM	709:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels	709:793	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	1	45	used	used	134:137	arg2	dressings					120:128	Medical dressings	112:128	Medical dressings	112:128	Medical dressings are used to protect damaged skin from external factors and provide a good healing environment.
31954789	7	46	theme	NS-FB	895:899	arg1	cells					911:915	NS-FB and HS-FB cells	895:915	NS-FB and HS-FB cells	895:915	The effects of hydrogels on the growth of NS-FB and HS-FB cells were studied in vitro.
31954789	6	47	theme	collagen	744:751	arg1	konjac					777:782	oxidized konjac	768:782	oxidized konjac	768:782	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	6	47	theme	collagen	744:751	arg1	/OKGM					761:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM	709:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels	709:793	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	1	48	theme	Medical	112:118	arg1	dressings					120:128	Medical dressings	112:128	Medical dressings	112:128	Medical dressings are used to protect damaged skin from external factors and provide a good healing environment.
31954789	2	49	theme	water	352:356	arg1	water					352:356	water	352:356	water	352:356	Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water.
31954789	2	49	theme	water	352:356	arg1	amounts					341:347	large amounts	335:347	large amounts of water	335:356	Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water.
31954789	7	50	theme	hydrogels	868:876	arg1	effects					857:863	The effects	853:863	The effects of hydrogels on the growth of NS-FB and HS-FB cells	853:915	The effects of hydrogels on the growth of NS-FB and HS-FB cells were studied in vitro.
31954789	8	51	theme	wound	1094:1098	arg1	field					1109:1113	wound dressing field	1094:1113	wound dressing field	1094:1113	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
31954789	6	52	theme	/COP	738:741	arg1	konjac					777:782	oxidized konjac	768:782	oxidized konjac	768:782	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	6	52	theme	/COP	738:741	arg1	/OKGM					761:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM	709:765	CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels	709:793	The structures of CMCS (carboxymethyl chitosan)/COP (collagen peptide)/OKGM (oxidized konjac) hydrogels were characterized by IR, NMR, X-ray diffraction and SEM.
31954789	1	53	theme	external	168:175	arg1	factors					177:183	external factors	168:183	external factors	168:183	Medical dressings are used to protect damaged skin from external factors and provide a good healing environment.
31954789	0	54	theme	konjac	85:90	arg1	hydrogel					102:109	konjac composite hydrogel	85:109	konjac composite hydrogel	85:109	Preparation and characterization of carboxymethyl chitosan/collagen peptide/oxidized konjac composite hydrogel.
31954789	2	55	theme	water	278:282	arg1	Hydrogels					225:233	Hydrogels	225:233	Hydrogels	225:233	Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water.
31954789	2	55	theme	water	278:282	arg1	aggregates					239:248	aggregates	239:248	aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water	239:356	Hydrogels are aggregates of hydrophilic polymers and water that have a three-dimensional space and can absorb large amounts of water.
31954789	8	56	theme	potential	1069:1077	arg1	application					1079:1089	potential application	1069:1089	potential application in wound dressing field	1069:1113	The results of these tests show that the composite hydrogel has excellent mechanical properties and biological activity, and has potential application in wound dressing field.
32901714	8	0	theme	1	1177:1177	arg1	µM					1179:1180	µM	1179:1180	µM	1179:1180	Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression.
32901714	4	1	theme	scaffolds	694:702	arg1	composition					675:685	composition	675:685	composition	675:685	The morphology and composition of the scaffolds were evaluated by SEM and EDS, respectively.
32901714	4	1	theme	scaffolds	694:702	arg1	morphology					660:669	morphology	660:669	morphology	660:669	The morphology and composition of the scaffolds were evaluated by SEM and EDS, respectively.
32901714	2	2	theme	aluminate	370:378	arg1	suspension					348:357	a suspension	346:357	a suspension of calcium aluminate (AlCa)	346:385	Chitosan scaffolds received a suspension of calcium aluminate (AlCa) and were then immersed into solutions containing SV.
32901714	9	3	theme	mineralized	1530:1540	arg1	deposition					1549:1558	mineralized matrix deposition	1530:1558	mineralized matrix deposition	1530:1558	Therefore, one can conclude that the incorporation of calcium aluminate and simvastatin in chitosan scaffolds had a synergistic effect on HDPCs, favoring odontogenic cell differentiation and mineralized matrix deposition.
32901714	8	4	from	phenotype	1211:1219	arg1	HDPCs					1228:1232	the HDPCs	1224:1232	the HDPCs	1224:1232	Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression.
32901714	8	5	dep	induced	1185:1191	arg1	up-regulated					1291:1302	up-regulated	1291:1302	up-regulated ALP, Col1A1, and DMP-1 expression	1291:1336	Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression.
32901714	8	5	dep	induced	1185:1191	arg1	showed					1241:1246	showed	1241:1246	showed enhanced mineralized matrix deposition	1241:1285	Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression.
32901714	7	6	theme	SV	1093:1094	arg1	dosages					1096:1102	The selected SV dosages	1080:1102	The selected SV dosages	1080:1102	The selected SV dosages were biocompatible with HDPCs.
32901714	7	6	theme	SV	1093:1094	arg1	biocompatible					1109:1121	biocompatible	1109:1121	biocompatible	1109:1121	The selected SV dosages were biocompatible with HDPCs.
32901714	2	7	theme	calcium	362:368	arg1	aluminate					370:378	calcium aluminate	362:378	calcium aluminate (AlCa)	362:385	Chitosan scaffolds received a suspension of calcium aluminate (AlCa) and were then immersed into solutions containing SV.
32901714	2	7	theme	calcium	362:368	arg1	AlCa					381:384	AlCa	381:384	AlCa	381:384	Chitosan scaffolds received a suspension of calcium aluminate (AlCa) and were then immersed into solutions containing SV.
32901714	9	8	from	incorporation	1376:1388	arg1	scaffolds					1439:1447	chitosan scaffolds	1430:1447	chitosan scaffolds	1430:1447	Therefore, one can conclude that the incorporation of calcium aluminate and simvastatin in chitosan scaffolds had a synergistic effect on HDPCs, favoring odontogenic cell differentiation and mineralized matrix deposition.
32901714	6	9	theme	chitosan	981:988	arg1	matrix					990:995	the chitosan matrix	977:995	the chitosan matrix	977:995	Calcium aluminate particles were incorporated into the chitosan matrix, which exhibited regular pores homogeneously distributed throughout its structure.
32901714	4	10	dep	morphology	660:669	arg1	The					656:658	The	656:658	The	656:658	The morphology and composition of the scaffolds were evaluated by SEM and EDS, respectively.
32901714	1	11	theme	low	287:289	arg1	doses					291:295	low doses	287:295	low doses of simvastatin (SV)	287:315	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	8	12	theme	µM	1179:1180	arg1	SV					1182:1183	1 µM SV	1177:1183	1 µM SV	1177:1183	Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression.
32901714	9	13	theme	matrix	1542:1547	arg1	deposition					1549:1558	mineralized matrix deposition	1530:1558	mineralized matrix deposition	1530:1558	Therefore, one can conclude that the incorporation of calcium aluminate and simvastatin in chitosan scaffolds had a synergistic effect on HDPCs, favoring odontogenic cell differentiation and mineralized matrix deposition.
32901714	3	14	dep	scaffolds	506:514	arg1	Control					526:532	Control	526:532	Control	526:532	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	14	dep	scaffolds	506:514	arg1	CHAlCa					517:522	CHAlCa	517:522	CHAlCa	517:522	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	8	15	with	scaffolds	1162:1170	arg1	SV					1182:1183	1 µM SV	1177:1183	1 µM SV	1177:1183	Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression.
32901714	3	16	theme	0.5	568:570	arg1	µM					572:573	µM	572:573	µM	572:573	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	5	17	theme	markers	903:909	arg1	expression					877:886	gene expression	872:886	mineralized matrix deposition as well as gene expression of odontogenic markers	831:909	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	5	17	theme	markers	903:909	arg1	deposition					850:859	mineralized matrix deposition	831:859	mineralized matrix deposition as well as gene expression of odontogenic markers	831:909	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	1	18	theme	present	111:117	arg1	study					119:123	The present study	107:123	The present study	107:123	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	5	19	theme	matrix	843:848	arg1	deposition					850:859	mineralized matrix deposition	831:859	mineralized matrix deposition as well as gene expression of odontogenic markers	831:909	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	8	20	theme	mineralized	1257:1267	arg1	deposition					1276:1285	enhanced mineralized matrix deposition	1248:1285	enhanced mineralized matrix deposition	1248:1285	Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression.
32901714	5	21	from	scaffolds	783:791	arg1	days					758:761	14 days	755:761	14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread	755:828	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	3	22	with	scaffolds	506:514	arg1	CHAlCa-SV1.0					641:652	CHAlCa-SV1.0	641:652	CHAlCa-SV1.0	641:652	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	22	with	scaffolds	506:514	arg1	SV					575:576	0.5 µM SV	568:576	0.5 µM SV (CHAlCa-SV0.5)	568:591	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	22	with	scaffolds	506:514	arg1	SV					637:638	1.0 µM SV	630:638	1.0 µM SV (CHAlCa-SV1.0)	630:653	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	22	with	scaffolds	506:514	arg1	CHAlCa-SV0.5					579:590	CHAlCa-SV0.5	579:590	CHAlCa-SV0.5	579:590	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	23	theme	following	444:452	arg1	groups					454:459	The following groups	440:459	The following groups	440:459	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	0	24	theme	Macro-Porous	21:32	arg1	Scaffold					61:68	Macro-Porous Chitosan-Calcium-Aluminate Scaffold	21:68	Macro-Porous Chitosan-Calcium-Aluminate Scaffold for Mineralized Tissue Regeneration	21:104	Simvastatin-Enriched Macro-Porous Chitosan-Calcium-Aluminate Scaffold for Mineralized Tissue Regeneration.
32901714	7	25	theme	selected	1084:1091	arg1	dosages					1096:1102	The selected SV dosages	1080:1102	The selected SV dosages	1080:1102	The selected SV dosages were biocompatible with HDPCs.
32901714	7	25	theme	selected	1084:1091	arg1	biocompatible					1109:1121	biocompatible	1109:1121	biocompatible	1109:1121	The selected SV dosages were biocompatible with HDPCs.
32901714	9	26	contain	had	1449:1451	arg1	incorporation					1376:1388	the incorporation	1372:1388	the incorporation of calcium aluminate and simvastatin in chitosan scaffolds	1372:1447	Therefore, one can conclude that the incorporation of calcium aluminate and simvastatin in chitosan scaffolds had a synergistic effect on HDPCs, favoring odontogenic cell differentiation and mineralized matrix deposition.
32901714	9	26	contain	had	1449:1451	arg2	effect					1467:1472	a synergistic effect	1453:1472	a synergistic effect	1453:1472	Therefore, one can conclude that the incorporation of calcium aluminate and simvastatin in chitosan scaffolds had a synergistic effect on HDPCs, favoring odontogenic cell differentiation and mineralized matrix deposition.
32901714	1	27	theme	chitosan	207:214	arg1	scaffolds					216:224	chitosan scaffolds	207:224	chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV)	207:315	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	8	28	theme	odontoblastic	1197:1209	arg1	phenotype					1211:1219	the odontoblastic phenotype	1193:1219	the odontoblastic phenotype in the HDPCs	1193:1232	Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression.
32901714	1	29	contain	containing	226:235	arg2	aluminate					245:253	calcium aluminate	237:253	calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV)	237:315	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	1	29	contain	containing	226:235	arg1	scaffolds					216:224	chitosan scaffolds	207:224	chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV)	207:315	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	1	29	contain	containing	226:235	arg2	CHAlCa					256:261	CHAlCa	256:261	CHAlCa	256:261	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	2	30	theme	Chitosan	318:325	arg1	scaffolds					327:335	Chitosan scaffolds	318:335	Chitosan scaffolds	318:335	Chitosan scaffolds received a suspension of calcium aluminate (AlCa) and were then immersed into solutions containing SV.
32901714	8	31	theme	matrix	1269:1274	arg1	deposition					1276:1285	enhanced mineralized matrix deposition	1248:1285	enhanced mineralized matrix deposition	1248:1285	Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression.
32901714	5	32	theme	cell	794:797	arg1	scaffolds					783:791	scaffolds	783:791	scaffolds	783:791	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	5	32	theme	cell	794:797	arg1	viability					799:807	cell viability	794:807	cell viability	794:807	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	1	33	theme	simvastatin	300:310	arg1	doses					291:295	low doses	287:295	low doses of simvastatin (SV)	287:315	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	9	34	theme	synergistic	1455:1465	arg1	effect					1467:1472	a synergistic effect	1453:1472	a synergistic effect	1453:1472	Therefore, one can conclude that the incorporation of calcium aluminate and simvastatin in chitosan scaffolds had a synergistic effect on HDPCs, favoring odontogenic cell differentiation and mineralized matrix deposition.
32901714	1	35	theme	odontogenic	139:149	arg1	potential					151:159	the odontogenic potential	135:159	the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV)	135:315	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	0	36	theme	Chitosan-Calcium-Aluminate	34:59	arg1	Scaffold					61:68	Macro-Porous Chitosan-Calcium-Aluminate Scaffold	21:68	Macro-Porous Chitosan-Calcium-Aluminate Scaffold for Mineralized Tissue Regeneration	21:104	Simvastatin-Enriched Macro-Porous Chitosan-Calcium-Aluminate Scaffold for Mineralized Tissue Regeneration.
32901714	3	37	theme	chitosan	536:543	arg1	calcium-aluminate					545:561	chitosan calcium-aluminate	536:561	chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5)	536:591	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	5	38	theme	gene	872:875	arg1	expression					877:886	gene expression	872:886	mineralized matrix deposition as well as gene expression of odontogenic markers	831:909	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	1	39	theme	calcium	237:243	arg1	CHAlCa					256:261	CHAlCa	256:261	CHAlCa	256:261	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	1	39	theme	calcium	237:243	arg1	aluminate					245:253	calcium aluminate	237:253	calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV)	237:315	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	0	40	theme	Mineralized	74:84	arg1	Regeneration					93:104	Mineralized Tissue Regeneration	74:104	Mineralized Tissue Regeneration	74:104	Simvastatin-Enriched Macro-Porous Chitosan-Calcium-Aluminate Scaffold for Mineralized Tissue Regeneration.
32901714	6	41	theme	aluminate	934:942	arg1	particles					944:952	Calcium aluminate particles	926:952	Calcium aluminate particles	926:952	Calcium aluminate particles were incorporated into the chitosan matrix, which exhibited regular pores homogeneously distributed throughout its structure.
32901714	8	42	theme	DMP-1	1321:1325	arg1	expression					1327:1336	ALP, Col1A1, and DMP-1 expression	1304:1336	expression	1327:1336	Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression.
32901714	9	43	theme	odontogenic	1493:1503	arg1	differentiation					1510:1524	odontogenic cell differentiation	1493:1524	odontogenic cell differentiation	1493:1524	Therefore, one can conclude that the incorporation of calcium aluminate and simvastatin in chitosan scaffolds had a synergistic effect on HDPCs, favoring odontogenic cell differentiation and mineralized matrix deposition.
32901714	3	44	with	calcium-aluminate	545:561	arg1	CHAlCa-SV1.0					641:652	CHAlCa-SV1.0	641:652	CHAlCa-SV1.0	641:652	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	44	with	calcium-aluminate	545:561	arg1	SV					575:576	0.5 µM SV	568:576	0.5 µM SV (CHAlCa-SV0.5)	568:591	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	44	with	calcium-aluminate	545:561	arg1	SV					637:638	1.0 µM SV	630:638	1.0 µM SV (CHAlCa-SV1.0)	630:653	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	44	with	calcium-aluminate	545:561	arg1	CHAlCa-SV0.5					579:590	CHAlCa-SV0.5	579:590	CHAlCa-SV0.5	579:590	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	6	45	theme	Calcium	926:932	arg1	particles					944:952	Calcium aluminate particles	926:952	Calcium aluminate particles	926:952	Calcium aluminate particles were incorporated into the chitosan matrix, which exhibited regular pores homogeneously distributed throughout its structure.
32901714	5	46	theme	HDPCs	766:770	arg1	culture					772:778	HDPCs culture	766:778	HDPCs culture on scaffolds, cell viability, adhesion and spread	766:828	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	9	47	theme	cell	1505:1508	arg1	differentiation					1510:1524	odontogenic cell differentiation	1493:1524	odontogenic cell differentiation	1493:1524	Therefore, one can conclude that the incorporation of calcium aluminate and simvastatin in chitosan scaffolds had a synergistic effect on HDPCs, favoring odontogenic cell differentiation and mineralized matrix deposition.
32901714	3	48	theme	chitosan	598:605	arg1	calcium-aluminate					607:623	chitosan calcium-aluminate	598:623	chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0)	598:653	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	9	49	theme	chitosan	1430:1437	arg1	scaffolds					1439:1447	chitosan scaffolds	1430:1447	chitosan scaffolds	1430:1447	Therefore, one can conclude that the incorporation of calcium aluminate and simvastatin in chitosan scaffolds had a synergistic effect on HDPCs, favoring odontogenic cell differentiation and mineralized matrix deposition.
32901714	8	50	theme	ALP	1304:1306	arg1	Col1A1					1309:1314	ALP, Col1A1, and DMP-1 expression	1304:1336	Col1A1	1309:1314	Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression.
32901714	5	51	theme	culture	772:778	arg1	days					758:761	14 days	755:761	14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread	755:828	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	7	52	with	biocompatible	1109:1121	arg1	HDPCs					1128:1132	HDPCs	1128:1132	HDPCs	1128:1132	The selected SV dosages were biocompatible with HDPCs.
32901714	0	53	theme	Tissue	86:91	arg1	Regeneration					93:104	Mineralized Tissue Regeneration	74:104	Mineralized Tissue Regeneration	74:104	Simvastatin-Enriched Macro-Porous Chitosan-Calcium-Aluminate Scaffold for Mineralized Tissue Regeneration.
32901714	1	54	theme	human	164:168	arg1	HDPCs					189:193	HDPCs	189:193	HDPCs	189:193	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	1	54	theme	human	164:168	arg1	cells					182:186	human dental pulp cells	164:186	human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV)	164:315	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	9	55	theme	calcium	1393:1399	arg1	aluminate					1401:1409	calcium aluminate	1393:1409	calcium aluminate	1393:1409	Therefore, one can conclude that the incorporation of calcium aluminate and simvastatin in chitosan scaffolds had a synergistic effect on HDPCs, favoring odontogenic cell differentiation and mineralized matrix deposition.
32901714	5	56	from	days	758:761	arg1	spread					823:828	spread	823:828	spread	823:828	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	5	56	from	days	758:761	arg1	adhesion					810:817	adhesion	810:817	adhesion	810:817	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	5	56	from	days	758:761	arg1	scaffolds					783:791	scaffolds	783:791	scaffolds	783:791	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	5	56	from	days	758:761	arg1	viability					799:807	cell viability	794:807	cell viability	794:807	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	3	57	theme	1.0	630:632	arg1	µM					634:635	µM	634:635	µM	634:635	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	1	58	theme	dental	170:175	arg1	HDPCs					189:193	HDPCs	189:193	HDPCs	189:193	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	1	58	theme	dental	170:175	arg1	cells					182:186	human dental pulp cells	164:186	human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV)	164:315	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	3	59	theme	µM	572:573	arg1	SV					575:576	0.5 µM SV	568:576	0.5 µM SV (CHAlCa-SV0.5)	568:591	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	59	theme	µM	572:573	arg1	CHAlCa-SV0.5					579:590	CHAlCa-SV0.5	579:590	CHAlCa-SV0.5	579:590	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	6	60	theme	regular	1014:1020	arg1	pores					1022:1026	regular pores	1014:1026	regular pores homogeneously distributed throughout its structure	1014:1077	Calcium aluminate particles were incorporated into the chitosan matrix, which exhibited regular pores homogeneously distributed throughout its structure.
32901714	5	61	theme	odontogenic	891:901	arg1	markers					903:909	odontogenic markers	891:909	odontogenic markers	891:909	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	8	62	theme	enhanced	1248:1255	arg1	deposition					1276:1285	enhanced mineralized matrix deposition	1248:1285	enhanced mineralized matrix deposition	1248:1285	Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression.
32901714	3	63	theme	µM	634:635	arg1	CHAlCa-SV1.0					641:652	CHAlCa-SV1.0	641:652	CHAlCa-SV1.0	641:652	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	63	theme	µM	634:635	arg1	SV					637:638	1.0 µM SV	630:638	1.0 µM SV (CHAlCa-SV1.0)	630:653	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	1	64	theme	pulp	177:180	arg1	HDPCs					189:193	HDPCs	189:193	HDPCs	189:193	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	1	64	theme	pulp	177:180	arg1	cells					182:186	human dental pulp cells	164:186	human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV)	164:315	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	3	65	theme	chitosan-calcium-aluminate	479:504	arg1	scaffolds					506:514	chitosan-calcium-aluminate scaffolds	479:514	chitosan-calcium-aluminate scaffolds (CHAlCa - Control)	479:533	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	66	with	calcium-aluminate	607:623	arg1	CHAlCa-SV1.0					641:652	CHAlCa-SV1.0	641:652	CHAlCa-SV1.0	641:652	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	66	with	calcium-aluminate	607:623	arg1	SV					575:576	0.5 µM SV	568:576	0.5 µM SV (CHAlCa-SV0.5)	568:591	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	66	with	calcium-aluminate	607:623	arg1	SV					637:638	1.0 µM SV	630:638	1.0 µM SV (CHAlCa-SV1.0)	630:653	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	66	with	calcium-aluminate	607:623	arg1	CHAlCa-SV0.5					579:590	CHAlCa-SV0.5	579:590	CHAlCa-SV0.5	579:590	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	2	67	contain	containing	425:434	arg2	SV					436:437	SV	436:437	SV	436:437	Chitosan scaffolds received a suspension of calcium aluminate (AlCa) and were then immersed into solutions containing SV.
32901714	2	67	contain	containing	425:434	arg1	solutions					415:423	solutions	415:423	solutions containing SV	415:437	Chitosan scaffolds received a suspension of calcium aluminate (AlCa) and were then immersed into solutions containing SV.
32901714	3	68	dep	established	466:476	arg1	calcium-aluminate					545:561	chitosan calcium-aluminate	536:561	chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5)	536:591	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	68	dep	established	466:476	arg1	calcium-aluminate					607:623	chitosan calcium-aluminate	598:623	chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0)	598:653	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	3	68	dep	established	466:476	arg1	scaffolds					506:514	chitosan-calcium-aluminate scaffolds	479:514	chitosan-calcium-aluminate scaffolds (CHAlCa - Control)	479:533	The following groups were established: chitosan-calcium-aluminate scaffolds (CHAlCa - Control), chitosan calcium-aluminate with 0.5 µM SV (CHAlCa-SV0.5), and chitosan calcium-aluminate with 1.0 µM SV (CHAlCa-SV1.0).
32901714	1	69	theme	cells	182:186	arg1	potential					151:159	the odontogenic potential	135:159	the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV)	135:315	The present study evaluated the odontogenic potential of human dental pulp cells (HDPCs) exposed to chitosan scaffolds containing calcium aluminate (CHAlCa) associated or not with low doses of simvastatin (SV).
32901714	5	70	theme	mineralized	831:841	arg1	deposition					850:859	mineralized matrix deposition	831:859	mineralized matrix deposition as well as gene expression of odontogenic markers	831:909	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	9	71	theme	simvastatin	1415:1425	arg1	incorporation					1376:1388	the incorporation	1372:1388	the incorporation of calcium aluminate and simvastatin in chitosan scaffolds	1372:1447	Therefore, one can conclude that the incorporation of calcium aluminate and simvastatin in chitosan scaffolds had a synergistic effect on HDPCs, favoring odontogenic cell differentiation and mineralized matrix deposition.
32901714	8	72	theme	Chitosan-calcium-aluminate	1135:1160	arg1	scaffolds					1162:1170	Chitosan-calcium-aluminate scaffolds	1135:1170	Chitosan-calcium-aluminate scaffolds with 1 µM SV	1135:1183	Chitosan-calcium-aluminate scaffolds with 1 µM SV induced the odontoblastic phenotype in the HDPCs, which showed enhanced mineralized matrix deposition and up-regulated ALP, Col1A1, and DMP-1 expression.
32901714	5	73	from	culture	772:778	arg1	spread					823:828	spread	823:828	spread	823:828	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	5	73	from	culture	772:778	arg1	adhesion					810:817	adhesion	810:817	adhesion	810:817	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	5	73	from	culture	772:778	arg1	scaffolds					783:791	scaffolds	783:791	scaffolds	783:791	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	5	73	from	culture	772:778	arg1	viability					799:807	cell viability	794:807	cell viability	794:807	After 14 days of HDPCs culture on scaffolds, cell viability, adhesion and spread, mineralized matrix deposition as well as gene expression of odontogenic markers were assessed.
32901714	9	74	theme	aluminate	1401:1409	arg1	incorporation					1376:1388	the incorporation	1372:1388	the incorporation of calcium aluminate and simvastatin in chitosan scaffolds	1372:1447	Therefore, one can conclude that the incorporation of calcium aluminate and simvastatin in chitosan scaffolds had a synergistic effect on HDPCs, favoring odontogenic cell differentiation and mineralized matrix deposition.
34281189	1	0	with	radezolid	219:227	arg1	HDAS-β-CD					282:290	HDAS-β-CD	282:290	HDAS-β-CD	282:290	Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid.
34281189	1	0	with	radezolid	219:227	arg1	-β-cyclodextrin					265:279	heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin	234:279	heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD)	234:291	Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid.
34281189	8	1	theme	explicit	1856:1863	arg1	water					1865:1869	explicit water	1856:1869	explicit water	1856:1869	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	6	2	theme	complexes	1461:1469	arg1	dynamics					1481:1488	their dynamics	1475:1488	their dynamics (geometry changes over time)	1475:1517	The most probable mean geometries of the studied supramolecular complexes and their dynamics (geometry changes over time) were determined by molecular dynamics methods.
34281189	6	2	theme	complexes	1461:1469	arg1	geometries					1420:1429	The most probable mean geometries	1397:1429	The most probable mean geometries of the studied supramolecular complexes	1397:1469	The most probable mean geometries of the studied supramolecular complexes and their dynamics (geometry changes over time) were determined by molecular dynamics methods.
34281189	1	3	theme	2,3-diacetyl-6-sulfo	244:263	arg1	HDAS-β-CD					282:290	HDAS-β-CD	282:290	HDAS-β-CD	282:290	Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid.
34281189	1	3	theme	2,3-diacetyl-6-sulfo	244:263	arg1	-β-cyclodextrin					265:279	heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin	234:279	heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD)	234:291	Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid.
34281189	2	4	theme	capillary	577:585	arg1	cEKC					618:621	cEKC	618:621	cEKC	618:621	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	2	4	theme	capillary	577:585	arg1	chromatography					602:615	capillary electrokinetic chromatography	577:615	capillary electrokinetic chromatography (cEKC)	577:622	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	6	5	theme	dynamics	1548:1555	arg1	methods					1557:1563	molecular dynamics methods	1538:1563	molecular dynamics methods	1538:1563	The most probable mean geometries of the studied supramolecular complexes and their dynamics (geometry changes over time) were determined by molecular dynamics methods.
34281189	2	6	with	interaction	403:413	arg1	HDAS-β-CD					558:566	HDAS-β-CD	558:566	HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods	558:685	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	3	7	theme	comprehensive	997:1009	arg1	basis					1011:1015	a comprehensive basis	995:1015	a comprehensive basis for MM studies	995:1030	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	1	8	theme	modeling	179:186	arg1	results					193:199	Molecular modeling (MM) results	169:199	Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD)	169:291	Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid.
34281189	8	9	theme	molecular	1888:1896	arg1	mechanics					1898:1906	molecular mechanics	1888:1906	molecular mechanics	1888:1906	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	7	10	theme	studies	1753:1759	arg1	conclusions					1730:1740	the conclusions	1726:1740	the conclusions of the NMR studies	1726:1759	Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies.
34281189	4	11	theme	direct	1072:1077	arg1	information					1079:1089	direct information	1072:1089	direct information on the geometry of the inclusion complexes	1072:1132	In turn, NMR provided, where possible, direct information on the geometry of the inclusion complexes and also provided the necessary structural information to validate the MM calculations.
34281189	3	12	theme	chiral	716:721	arg1	separation					723:732	chiral separation	716:732	chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method	716:834	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	3	13	theme	charged	767:773	arg1	derivatives					789:799	charged single isomer derivatives	767:799	charged single isomer derivatives of cyclodextrin	767:815	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	7	14	theme	inner	1626:1630	arg1	consistent					1710:1719	consistent	1710:1719	consistent	1710:1719	Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies.
34281189	7	14	theme	inner	1626:1630	arg1	part					1632:1635	mainly the inner part	1615:1635	mainly the inner part	1615:1635	Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies.
34281189	3	15	theme	analogues	751:759	arg1	separation					723:732	chiral separation	716:732	chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method	716:834	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	8	16	theme	Enthalpy	1762:1769	arg1	values					1771:1776	Enthalpy values	1762:1776	Enthalpy values of binding of complexes	1762:1800	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	8	17	dep	methods	2011:2017	arg1	MM/PBSA					1990:1996	MM/PBSA	1990:1996	MM/PBSA	1990:1996	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	8	17	dep	methods	2011:2017	arg1	methods					2011:2017	surface area continuum solvation (MM/PBSA and MM/GBSA) methods	1956:2017	surface area continuum solvation (MM/PBSA and MM/GBSA) methods	1956:2017	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	8	17	dep	methods	2011:2017	arg1	MM/GBSA					2002:2008	MM/GBSA	2002:2008	MM/GBSA	2002:2008	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	4	18	theme	structural	1166:1175	arg1	information					1177:1187	the necessary structural information	1152:1187	the necessary structural information to validate the MM calculations	1152:1219	In turn, NMR provided, where possible, direct information on the geometry of the inclusion complexes and also provided the necessary structural information to validate the MM calculations.
34281189	4	19	theme	complexes	1124:1132	arg1	geometry					1098:1105	the geometry	1094:1105	the geometry of the inclusion complexes	1094:1132	In turn, NMR provided, where possible, direct information on the geometry of the inclusion complexes and also provided the necessary structural information to validate the MM calculations.
34281189	5	20	theme	structure	1279:1287	arg1	understanding					1258:1270	the understanding	1254:1270	the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures	1254:1394	Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures.
34281189	3	21	theme	isomer	782:787	arg1	derivatives					789:799	charged single isomer derivatives	767:799	charged single isomer derivatives of cyclodextrin	767:815	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	8	22	theme	surface	1956:1962	arg1	MM/PBSA					1990:1996	MM/PBSA	1990:1996	MM/PBSA	1990:1996	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	8	22	theme	surface	1956:1962	arg1	methods					2011:2017	surface area continuum solvation (MM/PBSA and MM/GBSA) methods	1956:2017	surface area continuum solvation (MM/PBSA and MM/GBSA) methods	1956:2017	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	8	22	theme	surface	1956:1962	arg1	MM/GBSA					2002:2008	MM/GBSA	2002:2008	MM/GBSA	2002:2008	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	7	23	dep	part	1632:1635	arg1	binding					1673:1679	the external binding	1660:1679	the external binding	1660:1679	Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies.
34281189	7	23	dep	part	1632:1635	arg1	privileged					1689:1698	privileged	1689:1698	privileged	1689:1698	Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies.
34281189	11	24	theme	chiral	2435:2440	arg1	separation					2442:2451	the chiral separation	2431:2451	the chiral separation of the oxazolidinones using the modified cyclodextrin by computational methods	2431:2530	A fairly successful attempt was made to predict the chiral separation of the oxazolidinones using the modified cyclodextrin by computational methods.
34281189	3	25	theme	cEKC	824:827	arg1	method					829:834	the cEKC method	820:834	the cEKC method	820:834	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	8	26	theme	continuum	1969:1977	arg1	MM/PBSA					1990:1996	MM/PBSA	1990:1996	MM/PBSA	1990:1996	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	8	26	theme	continuum	1969:1977	arg1	methods					2011:2017	surface area continuum solvation (MM/PBSA and MM/GBSA) methods	1956:2017	surface area continuum solvation (MM/PBSA and MM/GBSA) methods	1956:2017	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	8	26	theme	continuum	1969:1977	arg1	MM/GBSA					2002:2008	MM/GBSA	2002:2008	MM/GBSA	2002:2008	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	11	27	theme	oxazolidinones	2460:2473	arg1	separation					2442:2451	the chiral separation	2431:2451	the chiral separation of the oxazolidinones using the modified cyclodextrin by computational methods	2431:2530	A fairly successful attempt was made to predict the chiral separation of the oxazolidinones using the modified cyclodextrin by computational methods.
34281189	2	28	theme	resonance	642:650	arg1	spectroscopy					658:669	nuclear magnetic resonance (NMR) spectroscopy	625:669	nuclear magnetic resonance (NMR) spectroscopy	625:669	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	9	29	from	pH	2077:2078	arg1	effect					2056:2061	the effect	2052:2061	the effect of changes in pH and composition of the solution on the strength and complexation process	2052:2151	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	3	30	theme	selector	898:905	arg1	selection					866:874	the selection	862:874	the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants	862:977	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	11	31	theme	computational	2510:2522	arg1	methods					2524:2530	computational methods	2510:2530	computational methods	2510:2530	A fairly successful attempt was made to predict the chiral separation of the oxazolidinones using the modified cyclodextrin by computational methods.
34281189	2	32	theme	nuclear	625:631	arg1	resonance					642:650	nuclear magnetic resonance	625:650	nuclear magnetic resonance (NMR) spectroscopy	625:669	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	2	32	theme	nuclear	625:631	arg1	NMR					653:655	NMR	653:655	NMR	653:655	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	5	33	theme	thermodynamics	1322:1335	arg1	understanding					1258:1270	the understanding	1254:1270	the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures	1254:1394	Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures.
34281189	9	34	from	changes	2066:2072	arg1	composition					2084:2094	composition	2084:2094	composition	2084:2094	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	9	34	from	changes	2066:2072	arg1	pH					2077:2078	pH	2077:2078	pH	2077:2078	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	0	35	theme	Complexes	32:40	arg1	Formation					19:27	the Formation	15:27	the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD	15:96	Explanation of the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD Using Molecular Modeling as a Complementary Technique to cEKC and NMR.
34281189	8	36	theme	molecular	1834:1842	arg1	dynamics					1844:1851	long-term molecular dynamics	1824:1851	long-term molecular dynamics in explicit water	1824:1869	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	3	37	theme	optimal	883:889	arg1	selector					898:905	the optimal chiral selector and separation conditions	879:931	selector	898:905	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	0	38	theme	Oxazolidinones	69:82	arg1	Representatives					50:64	Representatives	50:64	Representatives of Oxazolidinones and HDAS-β-CD	50:96	Explanation of the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD Using Molecular Modeling as a Complementary Technique to cEKC and NMR.
34281189	5	39	theme	complexation	1340:1351	arg1	thermodynamics					1322:1335	the thermodynamics	1318:1335	the thermodynamics of complexation	1318:1351	Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures.
34281189	5	39	theme	complexation	1340:1351	arg1	visualization					1362:1374	the visualization	1358:1374	the visualization of their structures	1358:1394	Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures.
34281189	5	39	theme	complexation	1340:1351	arg1	structure					1279:1287	the structure	1275:1287	the structure of diastereomeric complexes	1275:1315	Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures.
34281189	7	40	theme	external	1664:1671	arg1	binding					1673:1679	the external binding	1660:1679	the external binding	1660:1679	Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies.
34281189	7	40	theme	external	1664:1671	arg1	privileged					1689:1698	privileged	1689:1698	privileged	1689:1698	Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies.
34281189	5	41	theme	diastereomeric	1292:1305	arg1	complexes					1307:1315	diastereomeric complexes	1292:1315	diastereomeric complexes	1292:1315	Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures.
34281189	2	42	theme	oxazolidinone	425:437	arg1	ligands					439:445	chiral oxazolidinone ligands	418:445	chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid	418:550	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	1	43	with	tedizolid	205:213	arg1	HDAS-β-CD					282:290	HDAS-β-CD	282:290	HDAS-β-CD	282:290	Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid.
34281189	1	43	with	tedizolid	205:213	arg1	-β-cyclodextrin					265:279	heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin	234:279	heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD)	234:291	Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid.
34281189	3	44	theme	separation	911:920	arg1	conditions					922:931	the optimal chiral selector and separation conditions	879:931	conditions	922:931	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	2	45	theme	antibacterial	475:487	arg1	agents					489:494	antibacterial agents	475:494	antibacterial agents	475:494	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	2	45	theme	antibacterial	475:487	arg1	sutezolid					542:550	sutezolid	542:550	sutezolid	542:550	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	2	45	theme	antibacterial	475:487	arg1	tedizolid					516:524	tedizolid	516:524	tedizolid	516:524	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	2	45	theme	antibacterial	475:487	arg1	radezolid					527:535	radezolid	527:535	radezolid	527:535	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	2	45	theme	antibacterial	475:487	arg1	linezolid					505:513	linezolid	505:513	linezolid	505:513	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	9	46	theme	changes	2066:2072	arg1	effect					2056:2061	the effect	2052:2061	the effect of changes in pH and composition of the solution on the strength and complexation process	2052:2151	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	6	47	theme	probable	1406:1413	arg1	geometries					1420:1429	The most probable mean geometries	1397:1429	The most probable mean geometries of the studied supramolecular complexes	1397:1469	The most probable mean geometries of the studied supramolecular complexes and their dynamics (geometry changes over time) were determined by molecular dynamics methods.
34281189	9	48	theme	cEKC	2215:2218	arg1	study					2220:2224	the cEKC study	2211:2224	the cEKC study	2211:2224	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	3	49	theme	stoichiometry	942:954	arg1	selection					866:874	the selection	862:874	the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants	862:977	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	9	50	from	effect	2056:2061	arg1	composition					2084:2094	composition	2084:2094	composition	2084:2094	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	9	50	from	effect	2056:2061	arg1	pH					2077:2078	pH	2077:2078	pH	2077:2078	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	9	50	from	effect	2056:2061	arg1	process					2145:2151	the strength and complexation process	2115:2151	process	2145:2151	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	6	51	theme	geometry	1491:1498	arg1	changes					1500:1506	geometry changes	1491:1506	geometry changes over time	1491:1516	The most probable mean geometries of the studied supramolecular complexes and their dynamics (geometry changes over time) were determined by molecular dynamics methods.
34281189	3	52	theme	constants	969:977	arg1	selection					866:874	the selection	862:874	the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants	862:977	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	8	53	theme	solvation	1979:1987	arg1	MM/PBSA					1990:1996	MM/PBSA	1990:1996	MM/PBSA	1990:1996	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	8	53	theme	solvation	1979:1987	arg1	methods					2011:2017	surface area continuum solvation (MM/PBSA and MM/GBSA) methods	1956:2017	surface area continuum solvation (MM/PBSA and MM/GBSA) methods	1956:2017	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	8	53	theme	solvation	1979:1987	arg1	MM/GBSA					2002:2008	MM/GBSA	2002:2008	MM/GBSA	2002:2008	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	5	54	theme	visualization	1362:1374	arg1	understanding					1258:1270	the understanding	1254:1270	the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures	1254:1394	Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures.
34281189	2	55	theme	electrokinetic	587:600	arg1	cEKC					618:621	cEKC	618:621	cEKC	618:621	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	2	55	theme	electrokinetic	587:600	arg1	chromatography					602:615	capillary electrokinetic chromatography	577:615	capillary electrokinetic chromatography (cEKC)	577:622	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	9	56	theme	strength	2119:2126	arg1	process					2145:2151	the strength and complexation process	2115:2151	process	2145:2151	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	6	57	theme	supramolecular	1446:1459	arg1	complexes					1461:1469	the studied supramolecular complexes	1434:1469	the studied supramolecular complexes	1434:1469	The most probable mean geometries of the studied supramolecular complexes and their dynamics (geometry changes over time) were determined by molecular dynamics methods.
34281189	10	58	theme	dielectric	2243:2252	arg1	constant					2254:2261	the dielectric constant	2239:2261	the dielectric constant in the MM/PBSA and MM/GBSA calculations	2239:2301	By changing the dielectric constant in the MM/PBSA and MM/GBSA calculations, the effect of changing the solution to methanol/acetonitrile was investigated.
34281189	9	59	theme	complexation	2132:2143	arg1	process					2145:2151	the strength and complexation process	2115:2151	process	2145:2151	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	6	60	theme	molecular	1538:1546	arg1	methods					1557:1563	molecular dynamics methods	1538:1563	molecular dynamics methods	1538:1563	The most probable mean geometries of the studied supramolecular complexes and their dynamics (geometry changes over time) were determined by molecular dynamics methods.
34281189	1	61	theme	Molecular	169:177	arg1	MM					189:190	MM	189:190	MM	189:190	Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid.
34281189	1	61	theme	Molecular	169:177	arg1	modeling					179:186	Molecular modeling	169:186	Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD)	169:291	Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid.
34281189	4	62	theme	inclusion	1114:1122	arg1	complexes					1124:1132	the inclusion complexes	1110:1132	the inclusion complexes	1110:1132	In turn, NMR provided, where possible, direct information on the geometry of the inclusion complexes and also provided the necessary structural information to validate the MM calculations.
34281189	9	63	from	composition	2084:2094	arg1	effect					2056:2061	the effect	2052:2061	the effect of changes in pH and composition of the solution on the strength and complexation process	2052:2151	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	10	64	dep	MM/PBSA	2270:2276	arg1	the					2266:2268	the	2266:2268	the	2266:2268	By changing the dielectric constant in the MM/PBSA and MM/GBSA calculations, the effect of changing the solution to methanol/acetonitrile was investigated.
34281189	10	64	dep	MM/PBSA	2270:2276	arg1	calculations					2290:2301	calculations	2290:2301	calculations	2290:2301	By changing the dielectric constant in the MM/PBSA and MM/GBSA calculations, the effect of changing the solution to methanol/acetonitrile was investigated.
34281189	7	65	theme	cyclodextrin	1640:1651	arg1	consistent					1710:1719	consistent	1710:1719	consistent	1710:1719	Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies.
34281189	7	65	theme	cyclodextrin	1640:1651	arg1	part					1632:1635	mainly the inner part	1615:1635	mainly the inner part	1615:1635	Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies.
34281189	3	66	theme	MM	1021:1022	arg1	studies					1024:1030	MM studies	1021:1030	MM studies	1021:1030	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	3	67	theme	oxazolidinone	737:749	arg1	analogues					751:759	oxazolidinone analogues	737:759	oxazolidinone analogues using charged single isomer derivatives of cyclodextrin	737:815	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	0	68	theme	Complementary	128:140	arg1	Technique					142:150	a Complementary Technique	126:150	a Complementary Technique to cEKC and NMR	126:166	Explanation of the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD Using Molecular Modeling as a Complementary Technique to cEKC and NMR.
34281189	0	68	theme	Complementary	128:140	arg1	Modeling					114:121	Molecular Modeling	104:121	Molecular Modeling	104:121	Explanation of the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD Using Molecular Modeling as a Complementary Technique to cEKC and NMR.
34281189	3	69	theme	separation	723:732	arg1	Principles					702:711	Principles	702:711	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method	702:834	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	4	70	from	information	1079:1089	arg1	geometry					1098:1105	the geometry	1094:1105	the geometry of the inclusion complexes	1094:1132	In turn, NMR provided, where possible, direct information on the geometry of the inclusion complexes and also provided the necessary structural information to validate the MM calculations.
34281189	4	71	theme	necessary	1156:1164	arg1	information					1177:1187	the necessary structural information	1152:1187	the necessary structural information to validate the MM calculations	1152:1219	In turn, NMR provided, where possible, direct information on the geometry of the inclusion complexes and also provided the necessary structural information to validate the MM calculations.
34281189	3	72	theme	single	775:780	arg1	derivatives					789:799	charged single isomer derivatives	767:799	charged single isomer derivatives of cyclodextrin	767:815	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	2	73	theme	MM	676:677	arg1	methods					679:685	MM methods	676:685	MM methods	676:685	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	3	74	theme	cyclodextrin	804:815	arg1	derivatives					789:799	charged single isomer derivatives	767:799	charged single isomer derivatives of cyclodextrin	767:815	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	8	75	theme	area	1964:1967	arg1	MM/PBSA					1990:1996	MM/PBSA	1990:1996	MM/PBSA	1990:1996	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	8	75	theme	area	1964:1967	arg1	methods					2011:2017	surface area continuum solvation (MM/PBSA and MM/GBSA) methods	1956:2017	surface area continuum solvation (MM/PBSA and MM/GBSA) methods	1956:2017	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	8	75	theme	area	1964:1967	arg1	MM/GBSA					2002:2008	MM/GBSA	2002:2008	MM/GBSA	2002:2008	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	8	76	from	dynamics	1844:1851	arg1	water					1865:1869	explicit water	1856:1869	explicit water	1856:1869	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	0	77	theme	HDAS-β-CD	88:96	arg1	Representatives					50:64	Representatives	50:64	Representatives of Oxazolidinones and HDAS-β-CD	50:96	Explanation of the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD Using Molecular Modeling as a Complementary Technique to cEKC and NMR.
34281189	8	78	theme	binding	1781:1787	arg1	values					1771:1776	Enthalpy values	1762:1776	Enthalpy values of binding of complexes	1762:1800	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	7	79	theme	Oxazolidinone	1566:1578	arg1	ligands					1580:1586	Oxazolidinone ligands	1566:1586	Oxazolidinone ligands	1566:1586	Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies.
34281189	2	80	theme	agents	489:494	arg1	class					466:470	a new class	460:470	a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid	460:550	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	7	81	with	consistent	1710:1719	arg1	conclusions					1730:1740	the conclusions	1726:1740	the conclusions of the NMR studies	1726:1759	Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies.
34281189	0	82	theme	Molecular	104:112	arg1	Technique					142:150	a Complementary Technique	126:150	a Complementary Technique to cEKC and NMR	126:166	Explanation of the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD Using Molecular Modeling as a Complementary Technique to cEKC and NMR.
34281189	0	82	theme	Molecular	104:112	arg1	Modeling					114:121	Molecular Modeling	104:121	Molecular Modeling	104:121	Explanation of the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD Using Molecular Modeling as a Complementary Technique to cEKC and NMR.
34281189	8	83	theme	complexes	1792:1800	arg1	binding					1781:1787	binding	1781:1787	binding of complexes	1781:1800	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	2	84	theme	magnetic	633:640	arg1	resonance					642:650	nuclear magnetic resonance	625:650	nuclear magnetic resonance (NMR) spectroscopy	625:669	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	2	84	theme	magnetic	633:640	arg1	NMR					653:655	NMR	653:655	NMR	653:655	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	11	85	theme	modified	2485:2492	arg1	cyclodextrin					2494:2505	the modified cyclodextrin	2481:2505	the modified cyclodextrin by computational methods	2481:2530	A fairly successful attempt was made to predict the chiral separation of the oxazolidinones using the modified cyclodextrin by computational methods.
34281189	11	86	theme	successful	2392:2401	arg1	attempt					2403:2409	A fairly successful attempt	2383:2409	A fairly successful attempt	2383:2409	A fairly successful attempt was made to predict the chiral separation of the oxazolidinones using the modified cyclodextrin by computational methods.
34281189	6	87	theme	studied	1438:1444	arg1	complexes					1461:1469	the studied supramolecular complexes	1434:1469	the studied supramolecular complexes	1434:1469	The most probable mean geometries of the studied supramolecular complexes and their dynamics (geometry changes over time) were determined by molecular dynamics methods.
34281189	8	88	theme	long-term	1824:1832	arg1	dynamics					1844:1851	long-term molecular dynamics	1824:1851	long-term molecular dynamics in explicit water	1824:1869	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	3	89	theme	chiral	891:896	arg1	selector					898:905	the optimal chiral selector and separation conditions	879:931	selector	898:905	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	10	90	from	constant	2254:2261	arg1	MM/GBSA					2282:2288	MM/GBSA	2282:2288	MM/GBSA	2282:2288	By changing the dielectric constant in the MM/PBSA and MM/GBSA calculations, the effect of changing the solution to methanol/acetonitrile was investigated.
34281189	10	90	from	constant	2254:2261	arg1	MM/PBSA					2270:2276	MM/PBSA	2270:2276	MM/PBSA	2270:2276	By changing the dielectric constant in the MM/PBSA and MM/GBSA calculations, the effect of changing the solution to methanol/acetonitrile was investigated.
34281189	4	91	theme	MM	1205:1206	arg1	calculations					1208:1219	the MM calculations	1201:1219	the MM calculations	1201:1219	In turn, NMR provided, where possible, direct information on the geometry of the inclusion complexes and also provided the necessary structural information to validate the MM calculations.
34281189	0	92	theme	Formation	19:27	arg1	Explanation					0:10	Explanation	0:10	Explanation of the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD	0:96	Explanation of the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD Using Molecular Modeling as a Complementary Technique to cEKC and NMR.
34281189	9	93	theme	Computational	2020:2032	arg1	methods					2034:2040	Computational methods	2020:2040	Computational methods	2020:2040	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	3	94	theme	complex	934:940	arg1	stoichiometry					942:954	complex stoichiometry	934:954	complex stoichiometry	934:954	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	2	95	theme	ligands	439:445	arg1	interaction					403:413	interaction	403:413	interaction	403:413	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	5	96	theme	complexes	1307:1315	arg1	thermodynamics					1322:1335	the thermodynamics	1318:1335	the thermodynamics of complexation	1318:1351	Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures.
34281189	5	96	theme	complexes	1307:1315	arg1	visualization					1362:1374	the visualization	1358:1374	the visualization of their structures	1358:1394	Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures.
34281189	5	96	theme	complexes	1307:1315	arg1	structure					1279:1287	the structure	1275:1287	the structure of diastereomeric complexes	1275:1315	Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures.
34281189	2	97	theme	chiral	418:423	arg1	ligands					439:445	chiral oxazolidinone ligands	418:445	chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid	418:550	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	6	98	theme	mean	1415:1418	arg1	geometries					1420:1429	The most probable mean geometries	1397:1429	The most probable mean geometries of the studied supramolecular complexes	1397:1469	The most probable mean geometries of the studied supramolecular complexes and their dynamics (geometry changes over time) were determined by molecular dynamics methods.
34281189	3	99	theme	conditions	922:931	arg1	selection					866:874	the selection	862:874	the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants	862:977	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	8	100	dep	Poisson-Boltzmann	1913:1929	arg1	the					1909:1911	the	1909:1911	the	1909:1911	Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods.
34281189	2	101	theme	interaction	403:413	arg1	mechanism					390:398	The mechanism	386:398	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods	386:685	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	3	102	theme	binding	961:967	arg1	constants					969:977	binding constants	961:977	binding constants	961:977	Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies.
34281189	2	103	theme	new	462:464	arg1	class					466:470	a new class	460:470	a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid	460:550	The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described.
34281189	5	104	theme	structures	1385:1394	arg1	thermodynamics					1322:1335	the thermodynamics	1318:1335	the thermodynamics of complexation	1318:1351	Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures.
34281189	5	104	theme	structures	1385:1394	arg1	visualization					1362:1374	the visualization	1358:1374	the visualization of their structures	1358:1394	Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures.
34281189	5	104	theme	structures	1385:1394	arg1	structure					1279:1287	the structure	1275:1287	the structure of diastereomeric complexes	1275:1315	Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures.
34281189	6	105	dep	dynamics	1481:1488	arg1	changes					1500:1506	geometry changes	1491:1506	geometry changes over time	1491:1516	The most probable mean geometries of the studied supramolecular complexes and their dynamics (geometry changes over time) were determined by molecular dynamics methods.
34281189	7	106	theme	NMR	1749:1751	arg1	studies					1753:1759	the NMR studies	1745:1759	the NMR studies	1745:1759	Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies.
34281189	9	107	theme	solution	2103:2110	arg1	composition					2084:2094	composition	2084:2094	composition	2084:2094	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	9	107	theme	solution	2103:2110	arg1	pH					2077:2078	pH	2077:2078	pH	2077:2078	Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study.
34281189	1	108	theme	heptakis-	234:242	arg1	HDAS-β-CD					282:290	HDAS-β-CD	282:290	HDAS-β-CD	282:290	Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid.
34281189	1	108	theme	heptakis-	234:242	arg1	-β-cyclodextrin					265:279	heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin	234:279	heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD)	234:291	Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid.
34454206	9	0	theme	collagen	1471:1478	arg1	fibrils					1480:1486	the collagen fibrils	1467:1486	the collagen fibrils	1467:1486	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	3	1	theme	cartilage	514:522	arg1	properties					529:538	the patellar cartilage FRPE properties	501:538	the patellar cartilage FRPE properties followed by associating them with the structure and composition	501:602	Thus, our aim was to determine the patellar cartilage FRPE properties followed by associating them with the structure and composition.
34454206	3	2	dep	structure	578:586	arg1	the					574:576	the	574:576	the	574:576	Thus, our aim was to determine the patellar cartilage FRPE properties followed by associating them with the structure and composition.
34454206	0	3	theme	Functional	0:9	arg1	properties					26:35	Functional and structural properties	0:35	Functional and structural properties of human patellar articular cartilage in osteoarthritis	0:91	Functional and structural properties of human patellar articular cartilage in osteoarthritis.
34454206	1	4	theme	patellar	186:193	arg1	cartilage					195:203	human patellar cartilage	180:203	human patellar cartilage	180:203	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	9	5	from	proteoglycans	1572:1584	arg1	OA					1633:1634	human patellofemoral OA	1612:1634	human patellofemoral OA	1612:1634	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	10	6	theme	changes	1667:1673	arg1	important					1678:1686	important	1678:1686	important	1678:1686	The characterization of these changes is important to improve the representativeness of knee joint models in tissue and cell scale.
34454206	10	6	theme	changes	1667:1673	arg1	characterization					1641:1656	The characterization	1637:1656	The characterization of these changes	1637:1673	The characterization of these changes is important to improve the representativeness of knee joint models in tissue and cell scale.
34454206	2	7	theme	patellofemoral	276:289	arg1	loading					297:303	the patellofemoral joint loading	272:303	the patellofemoral joint loading	272:303	Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA.
34454206	5	8	theme	fibril	809:814	arg1	angle					828:832	collagen fibril orientation angle	800:832	collagen fibril orientation angle	800:832	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	9	9	from	loss	1564:1567	arg1	OA					1633:1634	human patellofemoral OA	1612:1634	human patellofemoral OA	1612:1634	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	9	10	theme	swelling	1600:1607	arg1	loss					1564:1567	the loss	1560:1567	the loss of proteoglycans and cartilage swelling in human patellofemoral OA	1560:1634	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	0	11	from	osteoarthritis	78:91	arg1	properties					26:35	Functional and structural properties	0:35	Functional and structural properties of human patellar articular cartilage in osteoarthritis	0:91	Functional and structural properties of human patellar articular cartilage in osteoarthritis.
34454206	1	12	theme	osteoarthritis	228:241	arg1	stages					218:223	different stages	208:223	different stages of osteoarthritis (OA)	208:246	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	9	13	theme	human	1612:1616	arg1	OA					1633:1634	human patellofemoral OA	1612:1634	human patellofemoral OA	1612:1634	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	0	14	from	cartilage	65:73	arg1	osteoarthritis					78:91	osteoarthritis	78:91	osteoarthritis	78:91	Functional and structural properties of human patellar articular cartilage in osteoarthritis.
34454206	8	15	theme	positive	1225:1232	arg1	associations					1234:1245	positive associations	1225:1245	positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01)	1225:1412	We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).
34454206	3	16	theme	patellar	505:512	arg1	properties					529:538	the patellar cartilage FRPE properties	501:538	the patellar cartilage FRPE properties followed by associating them with the structure and composition	501:602	Thus, our aim was to determine the patellar cartilage FRPE properties followed by associating them with the structure and composition.
34454206	0	17	theme	cartilage	65:73	arg1	properties					26:35	Functional and structural properties	0:35	Functional and structural properties of human patellar articular cartilage in osteoarthritis	0:91	Functional and structural properties of human patellar articular cartilage in osteoarthritis.
34454206	7	18	theme	negative	1096:1103	arg1	association					1105:1115	a negative association	1094:1115	a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p < 0.05)	1094:1205	Further, we observed a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p < 0.05).
34454206	1	19	theme	material	157:164	arg1	parameters					166:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters	105:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA)	105:246	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	6	20	theme	strain-dependency	965:981	arg1	factor					983:988	permeability strain-dependency factor	952:988	permeability strain-dependency factor	952:988	The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples.
34454206	8	21	theme	initial	1262:1268	arg1	permeability					1270:1281	initial permeability	1262:1281	initial permeability	1262:1281	We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).
34454206	10	22	theme	models	1736:1741	arg1	representativeness					1703:1720	the representativeness	1699:1720	the representativeness of knee joint models in tissue and cell scale	1699:1766	The characterization of these changes is important to improve the representativeness of knee joint models in tissue and cell scale.
34454206	1	23	theme	fibril-reinforced	109:125	arg1	parameters					166:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters	105:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA)	105:246	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	5	24	theme	FRPE	694:697	arg1	properties					708:717	the FRPE material properties	690:717	the FRPE material properties	690:717	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	2	25	dep	differ	456:461	arg1	compared					350:357	compared	350:357	compared to other knee joint locations	350:387	Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA.
34454206	6	26	theme	network	932:938	arg1	modulus					940:946	The initial fibril network modulus	913:946	The initial fibril network modulus	913:946	The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples.
34454206	6	26	theme	network	932:938	arg1	smaller					1007:1013	smaller	1007:1013	smaller	1007:1013	The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples.
34454206	7	27	theme	initial	1129:1135	arg1	modulus					1152:1158	the initial fibril network modulus	1125:1158	the initial fibril network modulus	1125:1158	Further, we observed a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p < 0.05).
34454206	6	28	theme	advanced	1018:1025	arg1	samples					1030:1036	advanced OA samples	1018:1036	advanced OA samples	1018:1036	The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples.
34454206	2	29	theme	functional	433:442	arg1	changes					444:450	structural and functional changes	418:450	structural and functional changes	418:450	Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA.
34454206	2	30	theme	joint	373:377	arg1	locations					379:387	other knee joint locations	362:387	other knee joint locations	362:387	Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA.
34454206	5	31	theme	proteoglycan	778:789	arg1	content					791:797	proteoglycan content	778:797	proteoglycan content	778:797	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	9	32	theme	fibrils	1480:1486	arg1	pretension					1453:1462	the reduced pretension	1441:1462	the reduced pretension of the collagen fibrils	1441:1486	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	2	33	theme	structural	418:427	arg1	changes					444:450	structural and functional changes	418:450	structural and functional changes	418:450	Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA.
34454206	0	34	theme	structural	15:24	arg1	properties					26:35	Functional and structural properties	0:35	Functional and structural properties of human patellar articular cartilage in osteoarthritis	0:91	Functional and structural properties of human patellar articular cartilage in osteoarthritis.
34454206	5	35	theme	samples	904:910	arg1	OA					894:895	OA	894:895	OA of the samples	894:910	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	1	36	theme	mechanical	146:155	arg1	parameters					166:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters	105:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA)	105:246	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	10	37	theme	cell	1757:1760	arg1	scale					1762:1766	cell scale	1757:1766	cell scale	1757:1766	The characterization of these changes is important to improve the representativeness of knee joint models in tissue and cell scale.
34454206	0	38	theme	patellar	46:53	arg1	cartilage					65:73	human patellar articular cartilage	40:73	human patellar articular cartilage in osteoarthritis	40:91	Functional and structural properties of human patellar articular cartilage in osteoarthritis.
34454206	8	39	dep	modulus	1364:1370	arg1	2					1334:1334	2	1334:1334	2	1334:1334	We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).
34454206	9	40	theme	reduced	1505:1511	arg1	modulus					1536:1542	the reduced initial fibril network modulus	1501:1542	the reduced initial fibril network modulus	1501:1542	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	10	41	theme	knee	1725:1728	arg1	models					1736:1741	knee joint models	1725:1741	knee joint models	1725:1741	The characterization of these changes is important to improve the representativeness of knee joint models in tissue and cell scale.
34454206	9	42	theme	fibril	1521:1526	arg1	modulus					1536:1542	the reduced initial fibril network modulus	1501:1542	the reduced initial fibril network modulus	1501:1542	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	6	43	theme	early	1055:1059	arg1	samples					1064:1070	early OA samples	1055:1070	early OA samples	1055:1070	The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples.
34454206	8	44	theme	fibril	1349:1354	arg1	modulus					1364:1370	the initial fibril network modulus	1337:1370	2) the initial fibril network modulus	1334:1370	We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).
34454206	2	45	theme	other	362:366	arg1	locations					379:387	other knee joint locations	362:387	other knee joint locations	362:387	Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA.
34454206	5	46	theme	optical	835:841	arg1	retardation					843:853	optical retardation	835:853	optical retardation (fibril parallelism)	835:874	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	5	46	theme	optical	835:841	arg1	parallelism					863:873	fibril parallelism	856:873	fibril parallelism	856:873	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	8	47	theme	network	1356:1362	arg1	modulus					1364:1370	the initial fibril network modulus	1337:1370	2) the initial fibril network modulus	1334:1370	We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).
34454206	2	48	theme	joint	291:295	arg1	loading					297:303	the patellofemoral joint loading	272:303	the patellofemoral joint loading	272:303	Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA.
34454206	1	49	theme	human	180:184	arg1	cartilage					195:203	human patellar cartilage	180:203	human patellar cartilage	180:203	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	9	50	from	swelling	1600:1607	arg1	OA					1633:1634	human patellofemoral OA	1612:1634	human patellofemoral OA	1612:1634	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	1	51	theme	cartilage	195:203	arg1	parameters					166:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters	105:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA)	105:246	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	6	52	theme	fibril	925:930	arg1	modulus					940:946	The initial fibril network modulus	913:946	The initial fibril network modulus	913:946	The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples.
34454206	6	52	theme	fibril	925:930	arg1	smaller					1007:1013	smaller	1007:1013	smaller	1007:1013	The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples.
34454206	9	53	theme	proteoglycans	1572:1584	arg1	loss					1564:1567	the loss	1560:1567	the loss of proteoglycans and cartilage swelling in human patellofemoral OA	1560:1634	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	3	54	theme	FRPE	524:527	arg1	properties					529:538	the patellar cartilage FRPE properties	501:538	the patellar cartilage FRPE properties followed by associating them with the structure and composition	501:602	Thus, our aim was to determine the patellar cartilage FRPE properties followed by associating them with the structure and composition.
34454206	5	55	theme	collagen	800:807	arg1	angle					828:832	collagen fibril orientation angle	800:832	collagen fibril orientation angle	800:832	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	9	56	theme	cartilage	1590:1598	arg1	swelling					1600:1607	cartilage swelling	1590:1607	cartilage swelling in human patellofemoral OA	1590:1634	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	4	57	theme	Osteochondral	605:617	arg1	n = 14					626:631	n = 14	626:631	n = 14	626:631	Osteochondral plugs (n = 14) were harvested from the patellae of six cadavers.
34454206	4	57	theme	Osteochondral	605:617	arg1	plugs					619:623	Osteochondral plugs	605:623	Osteochondral plugs (n = 14)	605:632	Osteochondral plugs (n = 14) were harvested from the patellae of six cadavers.
34454206	5	58	theme	orientation	816:826	arg1	angle					828:832	collagen fibril orientation angle	800:832	collagen fibril orientation angle	800:832	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	8	59	theme	optical	1376:1382	arg1	density					1384:1390	optical density	1376:1390	optical density (r = 0.670, p < 0.01)	1376:1412	We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).
34454206	6	60	theme	initial	917:923	arg1	modulus					940:946	The initial fibril network modulus	913:946	The initial fibril network modulus	913:946	The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples.
34454206	6	60	theme	initial	917:923	arg1	smaller					1007:1013	smaller	1007:1013	smaller	1007:1013	The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples.
34454206	1	61	theme	poroelastic	127:137	arg1	parameters					166:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters	105:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA)	105:246	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	9	62	theme	patellofemoral	1618:1631	arg1	OA					1633:1634	human patellofemoral OA	1612:1634	human patellofemoral OA	1612:1634	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	4	63	theme	cadavers	674:681	arg1	patellae					658:665	the patellae	654:665	the patellae of six cadavers	654:681	Osteochondral plugs (n = 14) were harvested from the patellae of six cadavers.
34454206	1	64	from	stages	218:223	arg1	parameters					166:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters	105:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA)	105:246	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	1	64	from	stages	218:223	arg1	Changes					94:100	Changes	94:100	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA)	94:246	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	1	65	theme	FRPE	140:143	arg1	parameters					166:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters	105:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA)	105:246	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	9	66	from	OA	1633:1634	arg1	loss					1564:1567	the loss	1560:1567	the loss of proteoglycans and cartilage swelling in human patellofemoral OA	1560:1634	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	7	67	theme	optical	1164:1170	arg1	retardation					1172:1182	optical retardation	1164:1182	optical retardation (r = -0.537, p < 0.05)	1164:1205	Further, we observed a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p < 0.05).
34454206	10	68	theme	joint	1730:1734	arg1	models					1736:1741	knee joint models	1725:1741	knee joint models	1725:1741	The characterization of these changes is important to improve the representativeness of knee joint models in tissue and cell scale.
34454206	1	69	theme	different	208:216	arg1	stages					218:223	different stages	208:223	different stages of osteoarthritis (OA)	208:246	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	5	70	theme	fibril	856:861	arg1	retardation					843:853	optical retardation	835:853	optical retardation (fibril parallelism)	835:874	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	5	70	theme	fibril	856:861	arg1	parallelism					863:873	fibril parallelism	856:873	fibril parallelism	856:873	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	0	71	from	properties	26:35	arg1	osteoarthritis					78:91	osteoarthritis	78:91	osteoarthritis	78:91	Functional and structural properties of human patellar articular cartilage in osteoarthritis.
34454206	7	72	theme	network	1144:1150	arg1	modulus					1152:1158	the initial fibril network modulus	1125:1158	the initial fibril network modulus	1125:1158	Further, we observed a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p < 0.05).
34454206	6	73	theme	permeability	952:963	arg1	factor					983:988	permeability strain-dependency factor	952:988	permeability strain-dependency factor	952:988	The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples.
34454206	7	74	theme	fibril	1137:1142	arg1	modulus					1152:1158	the initial fibril network modulus	1125:1158	the initial fibril network modulus	1125:1158	Further, we observed a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p < 0.05).
34454206	9	75	theme	reduced	1445:1451	arg1	pretension					1453:1462	the reduced pretension	1441:1462	the reduced pretension of the collagen fibrils	1441:1486	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	5	76	theme	material	699:706	arg1	properties					708:717	the FRPE material properties	690:717	the FRPE material properties	690:717	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	6	77	theme	OA	1027:1028	arg1	samples					1030:1036	advanced OA samples	1018:1036	advanced OA samples	1018:1036	The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples.
34454206	8	78	theme	optical	1287:1293	arg1	retardation					1295:1305	optical retardation	1287:1305	optical retardation	1287:1305	We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).
34454206	9	79	dep	linked	1548:1553	arg1	shown					1492:1496	shown	1492:1496	shown by the reduced initial fibril network modulus	1492:1542	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	5	80	theme	OA	894:895	arg1	state					885:889	the state	881:889	the state of OA of the samples	881:910	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	5	80	theme	OA	894:895	arg1	retardation					843:853	optical retardation	835:853	optical retardation (fibril parallelism)	835:874	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	5	80	theme	OA	894:895	arg1	angle					828:832	collagen fibril orientation angle	800:832	collagen fibril orientation angle	800:832	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	5	80	theme	OA	894:895	arg1	content					791:797	proteoglycan content	778:797	proteoglycan content	778:797	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	5	80	theme	OA	894:895	arg1	parallelism					863:873	fibril parallelism	856:873	fibril parallelism	856:873	Then, the FRPE material properties were determined, and those properties were associated with proteoglycan content, collagen fibril orientation angle, optical retardation (fibril parallelism), and the state of OA of the samples.
34454206	10	81	from	representativeness	1703:1720	arg1	tissue					1746:1751	tissue	1746:1751	tissue	1746:1751	The characterization of these changes is important to improve the representativeness of knee joint models in tissue and cell scale.
34454206	10	81	from	representativeness	1703:1720	arg1	scale					1762:1766	cell scale	1757:1766	cell scale	1757:1766	The characterization of these changes is important to improve the representativeness of knee joint models in tissue and cell scale.
34454206	2	82	theme	knee	368:371	arg1	locations					379:387	other knee joint locations	362:387	other knee joint locations	362:387	Further, the patellofemoral joint loading is thought to include more sliding and shear compared to other knee joint locations, thus, the relations between structural and functional changes may differ in OA.
34454206	0	83	theme	human	40:44	arg1	cartilage					65:73	human patellar articular cartilage	40:73	human patellar articular cartilage in osteoarthritis	40:91	Functional and structural properties of human patellar articular cartilage in osteoarthritis.
34454206	8	84	dep	density	1384:1390	arg1	p < 0.01					1404:1411	p < 0.01	1404:1411	p < 0.01	1404:1411	We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).
34454206	8	84	dep	density	1384:1390	arg1	r = 0.670					1393:1401	r = 0.670	1393:1401	r = 0.670	1393:1401	We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).
34454206	7	85	dep	retardation	1172:1182	arg1	p < 0.05					1197:1204	p < 0.05	1197:1204	p < 0.05	1197:1204	Further, we observed a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p < 0.05).
34454206	7	85	dep	retardation	1172:1182	arg1	r = -0.537					1185:1194	r = -0.537	1185:1194	r = -0.537	1185:1194	Further, we observed a negative association between the initial fibril network modulus and optical retardation (r = -0.537, p < 0.05).
34454206	0	86	theme	articular	55:63	arg1	cartilage					65:73	human patellar articular cartilage	40:73	human patellar articular cartilage in osteoarthritis	40:91	Functional and structural properties of human patellar articular cartilage in osteoarthritis.
34454206	9	87	theme	initial	1513:1519	arg1	modulus					1536:1542	the reduced initial fibril network modulus	1501:1542	the reduced initial fibril network modulus	1501:1542	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	6	88	theme	OA	1061:1062	arg1	samples					1064:1070	early OA samples	1055:1070	early OA samples	1055:1070	The initial fibril network modulus and permeability strain-dependency factor were 72% and 63% smaller in advanced OA samples when compared to early OA samples.
34454206	1	89	from	Changes	94:100	arg1	stages					218:223	different stages	208:223	different stages of osteoarthritis (OA)	208:246	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	1	89	from	Changes	94:100	arg1	parameters					166:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters	105:175	the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA)	105:246	Changes in the fibril-reinforced poroelastic (FRPE) mechanical material parameters of human patellar cartilage at different stages of osteoarthritis (OA) are not known.
34454206	8	90	dep	permeability	1270:1281	arg1	r = 0.547					1308:1316	r = 0.547	1308:1316	r = 0.547	1308:1316	We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).
34454206	8	90	dep	permeability	1270:1281	arg1	the					1258:1260	the	1258:1260	the	1258:1260	We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).
34454206	8	90	dep	permeability	1270:1281	arg1	1					1255:1255	1	1255:1255	1	1255:1255	We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).
34454206	9	91	theme	network	1528:1534	arg1	modulus					1536:1542	the reduced initial fibril network modulus	1501:1542	the reduced initial fibril network modulus	1501:1542	These results suggest that the reduced pretension of the collagen fibrils, as shown by the reduced initial fibril network modulus, is linked with the loss of proteoglycans and cartilage swelling in human patellofemoral OA.
34454206	8	92	theme	initial	1341:1347	arg1	modulus					1364:1370	the initial fibril network modulus	1337:1370	2) the initial fibril network modulus	1334:1370	We also observed positive associations between 1) the initial permeability and optical retardation (r = 0.547, p < 0.05), and 2) the initial fibril network modulus and optical density (r = 0.670, p < 0.01).
34492679	3	0	theme	pressure	689:696	arg1	DHPM					717:720	DHPM	717:720	DHPM	717:720	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	3	0	theme	pressure	689:696	arg1	microfluidization					698:714	dynamic high pressure microfluidization	676:714	dynamic high pressure microfluidization (DHPM)	676:721	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	4	1	theme	final	871:875	arg1	CMCS-LPs					904:911	CMCS-LPs	904:911	CMCS-LPs	904:911	Electron microscopy investigation reveals an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs).
34492679	4	1	theme	final	871:875	arg1	nanoliposomes					889:901	the final CMCS coated nanoliposomes	867:901	the final CMCS coated nanoliposomes (CMCS-LPs)	867:912	Electron microscopy investigation reveals an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs).
34492679	2	2	theme	poor	343:346	arg1	solubility					356:365	poor aqueous solubility	343:365	poor aqueous solubility	343:365	However, the inherent hydrophobic nature of MCFAs causes poor aqueous solubility and dissolution in the gastrointestinal (GI) tract, thus limiting their applications in aqueous foods.
34492679	5	3	theme	successful	963:972	arg1	coating					974:980	the successful coating	959:980	the successful coating of CMCS	959:988	Together with the FTIR results, it confirms the successful coating of CMCS.
34492679	7	4	from	release	1372:1378	arg1	fluid					1399:1403	the GI fluid	1392:1403	the GI fluid	1392:1403	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	6	5	theme	ζ-potential	1078:1088	arg1	value					1090:1094	a ζ-potential value	1076:1094	a ζ-potential value of around -18.5 mV, which helps to increase the stability by avoiding severe particle aggregation	1076:1192	More importantly, the resultant CMCS-LPs have a more negatively charged surface with a ζ-potential value of around -18.5 mV, which helps to increase the stability by avoiding severe particle aggregation.
34492679	3	6	theme	dynamic	676:682	arg1	DHPM					717:720	DHPM	717:720	DHPM	717:720	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	3	6	theme	dynamic	676:682	arg1	microfluidization					698:714	dynamic high pressure microfluidization	676:714	dynamic high pressure microfluidization (DHPM)	676:721	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	4	7	theme	coated	882:887	arg1	CMCS-LPs					904:911	CMCS-LPs	904:911	CMCS-LPs	904:911	Electron microscopy investigation reveals an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs).
34492679	4	7	theme	coated	882:887	arg1	nanoliposomes					889:901	the final CMCS coated nanoliposomes	867:901	the final CMCS coated nanoliposomes (CMCS-LPs)	867:912	Electron microscopy investigation reveals an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs).
34492679	4	8	theme	microscopy	758:767	arg1	investigation					769:781	Electron microscopy investigation	749:781	Electron microscopy investigation	749:781	Electron microscopy investigation reveals an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs).
34492679	5	9	theme	CMCS	985:988	arg1	coating					974:980	the successful coating	959:980	the successful coating of CMCS	959:988	Together with the FTIR results, it confirms the successful coating of CMCS.
34492679	5	10	theme	FTIR	933:936	arg1	results					938:944	the FTIR results	929:944	the FTIR results	929:944	Together with the FTIR results, it confirms the successful coating of CMCS.
34492679	2	11	from	applications	439:450	arg1	foods					463:467	aqueous foods	455:467	aqueous foods	455:467	However, the inherent hydrophobic nature of MCFAs causes poor aqueous solubility and dissolution in the gastrointestinal (GI) tract, thus limiting their applications in aqueous foods.
34492679	4	12	theme	CMCS	877:880	arg1	CMCS-LPs					904:911	CMCS-LPs	904:911	CMCS-LPs	904:911	Electron microscopy investigation reveals an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs).
34492679	4	12	theme	CMCS	877:880	arg1	nanoliposomes					889:901	the final CMCS coated nanoliposomes	867:901	the final CMCS coated nanoliposomes (CMCS-LPs)	867:912	Electron microscopy investigation reveals an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs).
34492679	0	13	dep	in	107:108	arg1	vitro					110:114	vitro	110:114	vitro	110:114	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	2	14	theme	hydrophobic	308:318	arg1	nature					320:325	the inherent hydrophobic nature	295:325	the inherent hydrophobic nature of MCFAs	295:334	However, the inherent hydrophobic nature of MCFAs causes poor aqueous solubility and dissolution in the gastrointestinal (GI) tract, thus limiting their applications in aqueous foods.
34492679	6	15	contain	have	1032:1035	arg1	CMCS-LPs					1023:1030	the resultant CMCS-LPs	1009:1030	the resultant CMCS-LPs	1009:1030	More importantly, the resultant CMCS-LPs have a more negatively charged surface with a ζ-potential value of around -18.5 mV, which helps to increase the stability by avoiding severe particle aggregation.
34492679	6	15	contain	have	1032:1035	arg2	surface					1063:1069	a more negatively charged surface	1037:1069	a more negatively charged surface	1037:1069	More importantly, the resultant CMCS-LPs have a more negatively charged surface with a ζ-potential value of around -18.5 mV, which helps to increase the stability by avoiding severe particle aggregation.
34492679	7	16	theme	long	1275:1278	arg1	period					1288:1293	a long storage period	1273:1293	a long storage period of 90 days at 4 °C	1273:1312	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	3	17	theme	nutraceutical	497:509	arg1	system					519:524	a nutraceutical carrier system	495:524	a nutraceutical carrier system	495:524	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	7	18	theme	storage	1280:1286	arg1	period					1288:1293	a long storage period	1273:1293	a long storage period of 90 days at 4 °C	1273:1312	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	0	19	theme	in	107:108	arg1	nanoliposomes					54:66	medium-chain fatty acid nanoliposomes	30:66	medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation	30:136	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	19	theme	in	107:108	arg1	investigation					124:136	in vitro release investigation	107:136	in vitro release investigation	107:136	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	7	20	theme	MCFAs	1383:1387	arg1	release					1372:1378	a more sustained release	1355:1378	a more sustained release of MCFAs in the GI fluid	1355:1403	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	2	21	theme	aqueous	455:461	arg1	foods					463:467	aqueous foods	455:467	aqueous foods	455:467	However, the inherent hydrophobic nature of MCFAs causes poor aqueous solubility and dissolution in the gastrointestinal (GI) tract, thus limiting their applications in aqueous foods.
34492679	3	22	theme	carrier	511:517	arg1	system					519:524	a nutraceutical carrier system	495:524	a nutraceutical carrier system	495:524	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	7	23	from	MCFAs	1383:1387	arg1	fluid					1399:1403	the GI fluid	1392:1403	the GI fluid	1392:1403	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	7	24	theme	encapsulated	1228:1239	arg1	MCFAs					1241:1245	the encapsulated MCFAs	1224:1245	the encapsulated MCFAs	1224:1245	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	2	25	theme	inherent	299:306	arg1	nature					320:325	the inherent hydrophobic nature	295:325	the inherent hydrophobic nature of MCFAs	295:334	However, the inherent hydrophobic nature of MCFAs causes poor aqueous solubility and dissolution in the gastrointestinal (GI) tract, thus limiting their applications in aqueous foods.
34492679	7	26	theme	GI	1396:1397	arg1	fluid					1399:1403	the GI fluid	1392:1403	the GI fluid	1392:1403	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	6	27	theme	charged	1055:1061	arg1	surface					1063:1069	a more negatively charged surface	1037:1069	a more negatively charged surface	1037:1069	More importantly, the resultant CMCS-LPs have a more negatively charged surface with a ζ-potential value of around -18.5 mV, which helps to increase the stability by avoiding severe particle aggregation.
34492679	0	28	theme	Carboxymethyl	0:12	arg1	chitosan					14:21	Carboxymethyl chitosan	0:21	Carboxymethyl chitosan	0:21	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	1	29	theme	other	259:263	arg1	disorders					275:283	other metabolic disorders	259:283	other metabolic disorders	259:283	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	2	30	from	solubility	356:365	arg1	tract					412:416	the gastrointestinal (GI) tract	386:416	the gastrointestinal (GI) tract	386:416	However, the inherent hydrophobic nature of MCFAs causes poor aqueous solubility and dissolution in the gastrointestinal (GI) tract, thus limiting their applications in aqueous foods.
34492679	0	31	theme	medium-chain	30:41	arg1	composition					80:90	composition	80:90	composition	80:90	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	31	theme	medium-chain	30:41	arg1	structure					69:77	structure	69:77	structure	69:77	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	31	theme	medium-chain	30:41	arg1	nanoliposomes					54:66	medium-chain fatty acid nanoliposomes	30:66	medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation	30:136	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	31	theme	medium-chain	30:41	arg1	investigation					124:136	in vitro release investigation	107:136	in vitro release investigation	107:136	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	31	theme	medium-chain	30:41	arg1	stability					93:101	stability	93:101	stability	93:101	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	1	32	theme	metabolic	265:273	arg1	disorders					275:283	other metabolic disorders	259:283	other metabolic disorders	259:283	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	4	33	theme	uncoated	832:839	arg1	UC-LPs					856:861	UC-LPs	856:861	UC-LPs	856:861	Electron microscopy investigation reveals an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs).
34492679	4	33	theme	uncoated	832:839	arg1	nanoliposomes					841:853	the uncoated nanoliposomes	828:853	the uncoated nanoliposomes (UC-LPs)	828:862	Electron microscopy investigation reveals an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs).
34492679	3	34	with	nanoliposomes	551:563	arg1	chitosan					584:591	carboxymethyl chitosan	570:591	carboxymethyl chitosan (CMCS)	570:598	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	3	34	with	nanoliposomes	551:563	arg1	CMCS					594:597	CMCS	594:597	CMCS	594:597	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	0	35	theme	release	116:122	arg1	nanoliposomes					54:66	medium-chain fatty acid nanoliposomes	30:66	medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation	30:136	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	35	theme	release	116:122	arg1	investigation					124:136	in vitro release investigation	107:136	in vitro release investigation	107:136	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	3	36	theme	well-designed	620:632	arg1	modification					735:746	surface modification	727:746	surface modification	727:746	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	3	36	theme	well-designed	620:632	arg1	processes					634:642	well-designed processes	620:642	well-designed processes	620:642	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	3	36	theme	well-designed	620:632	arg1	microfluidization					698:714	dynamic high pressure microfluidization	676:714	dynamic high pressure microfluidization (DHPM)	676:721	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	3	36	theme	well-designed	620:632	arg1	hydration					665:673	thin-film hydration	655:673	thin-film hydration	655:673	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	2	37	theme	GI	408:409	arg1	tract					412:416	the gastrointestinal (GI) tract	386:416	the gastrointestinal (GI) tract	386:416	However, the inherent hydrophobic nature of MCFAs causes poor aqueous solubility and dissolution in the gastrointestinal (GI) tract, thus limiting their applications in aqueous foods.
34492679	0	38	theme	acid	49:52	arg1	composition					80:90	composition	80:90	composition	80:90	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	38	theme	acid	49:52	arg1	structure					69:77	structure	69:77	structure	69:77	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	38	theme	acid	49:52	arg1	nanoliposomes					54:66	medium-chain fatty acid nanoliposomes	30:66	medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation	30:136	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	38	theme	acid	49:52	arg1	investigation					124:136	in vitro release investigation	107:136	in vitro release investigation	107:136	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	38	theme	acid	49:52	arg1	stability					93:101	stability	93:101	stability	93:101	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	3	39	theme	surface	727:733	arg1	modification					735:746	surface modification	727:746	surface modification	727:746	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	3	40	theme	processes	634:642	arg1	series					610:615	a series	608:615	a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification	608:746	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	7	41	theme	new	1322:1324	arg1	system					1334:1339	the new carrier system	1318:1339	the new carrier system	1318:1339	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	1	42	theme	easy	195:198	arg1	acids					158:162	Medium-chain fatty acids	139:162	Medium-chain fatty acids (MCFAs)	139:170	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	1	42	theme	easy	195:198	arg1	source					207:212	an easy energy source	192:212	an easy energy source	192:212	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	0	43	theme	fatty	43:47	arg1	composition					80:90	composition	80:90	composition	80:90	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	43	theme	fatty	43:47	arg1	structure					69:77	structure	69:77	structure	69:77	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	43	theme	fatty	43:47	arg1	nanoliposomes					54:66	medium-chain fatty acid nanoliposomes	30:66	medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation	30:136	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	43	theme	fatty	43:47	arg1	investigation					124:136	in vitro release investigation	107:136	in vitro release investigation	107:136	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	43	theme	fatty	43:47	arg1	stability					93:101	stability	93:101	stability	93:101	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	4	44	theme	Electron	749:756	arg1	microscopy					758:767	Electron microscopy	749:767	Electron microscopy investigation	749:781	Electron microscopy investigation reveals an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs).
34492679	0	45	dep	nanoliposomes	54:66	arg1	composition					80:90	composition	80:90	composition	80:90	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	45	dep	nanoliposomes	54:66	arg1	structure					69:77	structure	69:77	structure	69:77	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	45	dep	nanoliposomes	54:66	arg1	nanoliposomes					54:66	medium-chain fatty acid nanoliposomes	30:66	medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation	30:136	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	45	dep	nanoliposomes	54:66	arg1	investigation					124:136	in vitro release investigation	107:136	in vitro release investigation	107:136	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	0	45	dep	nanoliposomes	54:66	arg1	stability					93:101	stability	93:101	stability	93:101	Carboxymethyl chitosan coated medium-chain fatty acid nanoliposomes: structure, composition, stability and in vitro release investigation.
34492679	2	46	from	dissolution	371:381	arg1	tract					412:416	the gastrointestinal (GI) tract	386:416	the gastrointestinal (GI) tract	386:416	However, the inherent hydrophobic nature of MCFAs causes poor aqueous solubility and dissolution in the gastrointestinal (GI) tract, thus limiting their applications in aqueous foods.
34492679	1	47	theme	energy	200:205	arg1	acids					158:162	Medium-chain fatty acids	139:162	Medium-chain fatty acids (MCFAs)	139:170	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	1	47	theme	energy	200:205	arg1	source					207:212	an easy energy source	192:212	an easy energy source	192:212	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	7	48	from	°C	1311:1312	arg1	period					1288:1293	a long storage period	1273:1293	a long storage period of 90 days at 4 °C	1273:1312	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	7	49	theme	days	1301:1304	arg1	period					1288:1293	a long storage period	1273:1293	a long storage period of 90 days at 4 °C	1273:1312	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	7	50	from	fluid	1399:1403	arg1	release					1372:1378	a more sustained release	1355:1378	a more sustained release of MCFAs in the GI fluid	1355:1403	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	2	51	theme	MCFAs	330:334	arg1	nature					320:325	the inherent hydrophobic nature	295:325	the inherent hydrophobic nature of MCFAs	295:334	However, the inherent hydrophobic nature of MCFAs causes poor aqueous solubility and dissolution in the gastrointestinal (GI) tract, thus limiting their applications in aqueous foods.
34492679	3	52	theme	thin-film	655:663	arg1	hydration					665:673	thin-film hydration	655:673	thin-film hydration	655:673	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	3	53	theme	carboxymethyl	570:582	arg1	chitosan					584:591	carboxymethyl chitosan	570:591	carboxymethyl chitosan (CMCS)	570:598	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	3	53	theme	carboxymethyl	570:582	arg1	CMCS					594:597	CMCS	594:597	CMCS	594:597	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	6	54	theme	severe	1166:1171	arg1	aggregation					1182:1192	severe particle aggregation	1166:1192	severe particle aggregation	1166:1192	More importantly, the resultant CMCS-LPs have a more negatively charged surface with a ζ-potential value of around -18.5 mV, which helps to increase the stability by avoiding severe particle aggregation.
34492679	4	55	theme	obvious	794:800	arg1	evolution					813:821	an obvious morphology evolution	791:821	an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs)	791:912	Electron microscopy investigation reveals an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs).
34492679	7	56	theme	carrier	1326:1332	arg1	system					1334:1339	the new carrier system	1318:1339	the new carrier system	1318:1339	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	6	57	theme	resultant	1013:1021	arg1	CMCS-LPs					1023:1030	the resultant CMCS-LPs	1009:1030	the resultant CMCS-LPs	1009:1030	More importantly, the resultant CMCS-LPs have a more negatively charged surface with a ζ-potential value of around -18.5 mV, which helps to increase the stability by avoiding severe particle aggregation.
34492679	7	58	theme	sustained	1362:1370	arg1	release					1372:1378	a more sustained release	1355:1378	a more sustained release of MCFAs in the GI fluid	1355:1403	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	4	59	from	nanoliposomes	841:853	arg1	evolution					813:821	an obvious morphology evolution	791:821	an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs)	791:912	Electron microscopy investigation reveals an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs).
34492679	1	60	theme	Medium-chain	139:150	arg1	acids					158:162	Medium-chain fatty acids	139:162	Medium-chain fatty acids (MCFAs)	139:170	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	1	60	theme	Medium-chain	139:150	arg1	source					207:212	an easy energy source	192:212	an easy energy source	192:212	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	1	60	theme	Medium-chain	139:150	arg1	ingredient					225:234	active ingredient	218:234	active ingredient	218:234	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	1	60	theme	Medium-chain	139:150	arg1	MCFAs					165:169	MCFAs	165:169	MCFAs	165:169	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	2	61	theme	gastrointestinal	390:405	arg1	tract					412:416	the gastrointestinal (GI) tract	386:416	the gastrointestinal (GI) tract	386:416	However, the inherent hydrophobic nature of MCFAs causes poor aqueous solubility and dissolution in the gastrointestinal (GI) tract, thus limiting their applications in aqueous foods.
34492679	6	62	theme	particle	1173:1180	arg1	aggregation					1182:1192	severe particle aggregation	1166:1192	severe particle aggregation	1166:1192	More importantly, the resultant CMCS-LPs have a more negatively charged surface with a ζ-potential value of around -18.5 mV, which helps to increase the stability by avoiding severe particle aggregation.
34492679	1	63	theme	fatty	152:156	arg1	acids					158:162	Medium-chain fatty acids	139:162	Medium-chain fatty acids (MCFAs)	139:170	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	1	63	theme	fatty	152:156	arg1	source					207:212	an easy energy source	192:212	an easy energy source	192:212	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	1	63	theme	fatty	152:156	arg1	ingredient					225:234	active ingredient	218:234	active ingredient	218:234	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	1	63	theme	fatty	152:156	arg1	MCFAs					165:169	MCFAs	165:169	MCFAs	165:169	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	1	64	theme	active	218:223	arg1	acids					158:162	Medium-chain fatty acids	139:162	Medium-chain fatty acids (MCFAs)	139:170	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	1	64	theme	active	218:223	arg1	ingredient					225:234	active ingredient	218:234	active ingredient	218:234	Medium-chain fatty acids (MCFAs) have been proven as an easy energy source and active ingredient to prevent obesity and other metabolic disorders.
34492679	7	65	theme	above	1208:1212	arg1	benefits					1214:1221	the above benefits	1204:1221	the above benefits	1204:1221	Owing to the above benefits, the encapsulated MCFAs can be safely retained in a long storage period of 90 days at 4 °C and the new carrier system also exhibits a more sustained release of MCFAs in the GI fluid.
34492679	3	66	theme	high	684:687	arg1	DHPM					717:720	DHPM	717:720	DHPM	717:720	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	3	66	theme	high	684:687	arg1	microfluidization					698:714	dynamic high pressure microfluidization	676:714	dynamic high pressure microfluidization (DHPM)	676:721	To address these issues, a nutraceutical carrier system was developed by coating nanoliposomes with carboxymethyl chitosan (CMCS) through a series of well-designed processes, including thin-film hydration, dynamic high pressure microfluidization (DHPM) and surface modification.
34492679	4	67	theme	morphology	802:811	arg1	evolution					813:821	an obvious morphology evolution	791:821	an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs)	791:912	Electron microscopy investigation reveals an obvious morphology evolution from the uncoated nanoliposomes (UC-LPs) to the final CMCS coated nanoliposomes (CMCS-LPs).
34492679	2	68	theme	aqueous	348:354	arg1	solubility					356:365	poor aqueous solubility	343:365	poor aqueous solubility	343:365	However, the inherent hydrophobic nature of MCFAs causes poor aqueous solubility and dissolution in the gastrointestinal (GI) tract, thus limiting their applications in aqueous foods.
34343208	0	0	theme	rice	71:74	arg1	flours					76:81	Thai indigenous brown rice flours	49:81	Thai indigenous brown rice flours	49:81	Chemical, physical, and functional properties of Thai indigenous brown rice flours.
34343208	1	1	theme	Jasmine	263:269	arg1	JMRF					283:286	JMRF	283:286	JMRF	283:286	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	1	theme	Jasmine	263:269	arg1	flour					276:280	brown Jasmine rice flour	257:280	brown Jasmine rice flour (JMRF)	257:287	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	10	2	from	information	1331:1341	arg1	flour					1367:1371	Thai indigenous rice flour	1346:1371	Thai indigenous rice flour that can be used in food preparations for specific uses	1346:1427	The findings offered fundamental information on Thai indigenous rice flour that can be used in food preparations for specific uses.
34343208	4	3	theme	low	556:558	arg1	dw					613:614	0.1-0.3 mg GAE/g dw	596:614	0.1-0.3 mg GAE/g dw	596:614	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	4	3	theme	low	556:558	arg1	content					587:593	low total extractable phenolic content	556:593	low total extractable phenolic content (0.1-0.3 mg GAE/g dw)	556:615	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	0	4	theme	brown	65:69	arg1	flours					76:81	Thai indigenous brown rice flours	49:81	Thai indigenous brown rice flours	49:81	Chemical, physical, and functional properties of Thai indigenous brown rice flours.
34343208	1	5	theme	rice	271:274	arg1	JMRF					283:286	JMRF	283:286	JMRF	283:286	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	5	theme	rice	271:274	arg1	flour					276:280	brown Jasmine rice flour	257:280	brown Jasmine rice flour (JMRF)	257:287	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	5	6	theme	swelling	837:844	arg1	power					846:850	swelling power	837:850	swelling power (5.71-6.84 g/g)	837:866	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	6	theme	swelling	837:844	arg1	g/g					863:865	5.71-6.84 g/g	853:865	5.71-6.84 g/g	853:865	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	1	7	theme	Nat	332:334	arg1	variety					338:344	Chai Nat 1 variety	327:344	Chai Nat 1 variety	327:344	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	5	8	theme	water	723:727	arg1	capacity					740:747	water absorption capacity	723:747	water absorption capacity (0.71-1.17 g/g)	723:763	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	8	theme	water	723:727	arg1	g/g					760:762	0.71-1.17 g/g	750:762	0.71-1.17 g/g	750:762	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	9	9	theme	functional	1207:1216	arg1	qualities					1231:1239	the chemical, physical, functional, and pasting qualities	1183:1239	the chemical, physical, functional, and pasting qualities of flours	1183:1249	Overall, the chemical, physical, functional, and pasting qualities of flours were substantially influenced by rice variety.
34343208	4	10	theme	DPPH●	627:631	arg1	activity					644:651	some DPPH● scavenging activity	622:651	some DPPH● scavenging activity (38.87-46.77%)	622:666	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	4	10	theme	DPPH●	627:631	arg1	%					665:665	38.87-46.77%	654:665	38.87-46.77%	654:665	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	1	11	from	aspects	230:236	arg1	comparison					241:250	comparison	241:250	comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety	241:344	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	8	12	theme	pasting	1071:1077	arg1	properties					1079:1088	The pasting properties	1067:1088	The pasting properties	1067:1088	The pasting properties differed among rice flours and the lowest pasting temperature was observed in CMRF.
34343208	2	13	theme	different	371:379	arg1	composition					390:400	different chemical composition	371:400	different chemical composition	371:400	All the rice flours had different chemical composition, physical characteristic, and techno-functionality.
34343208	0	14	theme	flours	76:81	arg1	properties					35:44	Chemical, physical, and functional properties	0:44	Chemical, physical, and functional properties of Thai indigenous brown rice flours	0:81	Chemical, physical, and functional properties of Thai indigenous brown rice flours.
34343208	9	15	theme	flours	1244:1249	arg1	qualities					1231:1239	the chemical, physical, functional, and pasting qualities	1183:1239	the chemical, physical, functional, and pasting qualities of flours	1183:1249	Overall, the chemical, physical, functional, and pasting qualities of flours were substantially influenced by rice variety.
34343208	6	16	theme	least	889:893	arg1	concentration					904:916	The least gelation concentration	885:916	The least gelation concentration	885:916	The least gelation concentration ranged from 4.0 to 8.0% where KMRF was easier to form gel than JMRF, and NKRF/CMRF.
34343208	2	17	theme	physical	403:410	arg1	characteristic					412:425	physical characteristic	403:425	physical characteristic	403:425	All the rice flours had different chemical composition, physical characteristic, and techno-functionality.
34343208	4	18	theme	extractable	566:576	arg1	dw					613:614	0.1-0.3 mg GAE/g dw	596:614	0.1-0.3 mg GAE/g dw	596:614	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	4	18	theme	extractable	566:576	arg1	content					587:593	low total extractable phenolic content	556:593	low total extractable phenolic content (0.1-0.3 mg GAE/g dw)	556:615	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	5	19	theme	bulk	691:694	arg1	density					696:702	the bulk density	687:702	the bulk density (1.36-1.83 g/cm3)	687:720	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	19	theme	bulk	691:694	arg1	g/cm3					715:719	1.36-1.83 g/cm3	705:719	1.36-1.83 g/cm3	705:719	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	10	20	theme	Thai	1346:1349	arg1	flour					1367:1371	Thai indigenous rice flour	1346:1371	Thai indigenous rice flour that can be used in food preparations for specific uses	1346:1427	The findings offered fundamental information on Thai indigenous rice flour that can be used in food preparations for specific uses.
34343208	10	21	theme	food	1393:1396	arg1	preparations					1398:1409	food preparations	1393:1409	food preparations for specific uses	1393:1427	The findings offered fundamental information on Thai indigenous rice flour that can be used in food preparations for specific uses.
34343208	9	22	theme	rice	1284:1287	arg1	variety					1289:1295	rice variety	1284:1295	rice variety	1284:1295	Overall, the chemical, physical, functional, and pasting qualities of flours were substantially influenced by rice variety.
34343208	3	23	theme	%	529:529	arg1	type					512:515	a low amylose type	498:515	a low amylose type (19.56-21.25% dw)	498:533	The KMRF, NKRF, and JMRF were classified as a low amylose type (19.56-21.25% dw).
34343208	3	23	theme	%	529:529	arg1	dw					531:532	19.56-21.25% dw	518:532	19.56-21.25% dw	518:532	The KMRF, NKRF, and JMRF were classified as a low amylose type (19.56-21.25% dw).
34343208	8	24	theme	rice	1105:1108	arg1	flours					1110:1115	rice flours	1105:1115	rice flours	1105:1115	The pasting properties differed among rice flours and the lowest pasting temperature was observed in CMRF.
34343208	6	25	dep	8.0	937:939	arg1	to					934:935	to	934:935	to	934:935	The least gelation concentration ranged from 4.0 to 8.0% where KMRF was easier to form gel than JMRF, and NKRF/CMRF.
34343208	0	26	theme	Chemical	0:7	arg1	properties					35:44	Chemical, physical, and functional properties	0:44	Chemical, physical, and functional properties of Thai indigenous brown rice flours	0:81	Chemical, physical, and functional properties of Thai indigenous brown rice flours.
34343208	5	27	theme	oil	792:794	arg1	capacity					807:814	oil absorption capacity	792:814	oil absorption capacity (1.39-2.49 g/g)	792:830	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	27	theme	oil	792:794	arg1	g/g					827:829	1.39-2.49 g/g	817:829	1.39-2.49 g/g	817:829	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	1	28	theme	Khai	161:164	arg1	flours					111:116	Thai indigenous brown rice flours	84:116	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand	84:151	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	28	theme	Khai	161:164	arg1	Rin					170:172	Khai Mod Rin	161:172	Khai Mod Rin (KMRF)	161:179	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	28	theme	Khai	161:164	arg1	NKRF					197:200	NKRF	197:200	NKRF	197:200	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	28	theme	Khai	161:164	arg1	KMRF					175:178	KMRF	175:178	KMRF	175:178	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	10	29	theme	fundamental	1319:1329	arg1	information					1331:1341	fundamental information	1319:1341	fundamental information on Thai indigenous rice flour that can be used in food preparations for specific uses	1319:1427	The findings offered fundamental information on Thai indigenous rice flour that can be used in food preparations for specific uses.
34343208	7	30	dep	low	1049:1051	arg1	low					1049:1051	low	1049:1051	low	1049:1051	The foam capacity of the flours was relatively low (1.30-2.60%).
34343208	7	30	dep	low	1049:1051	arg1	%					1063:1063	1.30-2.60%	1054:1063	1.30-2.60%	1054:1063	The foam capacity of the flours was relatively low (1.30-2.60%).
34343208	7	30	dep	low	1049:1051	arg1	capacity					1011:1018	The foam capacity	1002:1018	The foam capacity of the flours	1002:1032	The foam capacity of the flours was relatively low (1.30-2.60%).
34343208	1	31	theme	Thai	84:87	arg1	flours					111:116	Thai indigenous brown rice flours	84:116	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand	84:151	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	31	theme	Thai	84:87	arg1	Rin					170:172	Khai Mod Rin	161:172	Khai Mod Rin (KMRF)	161:179	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	31	theme	Thai	84:87	arg1	Khuea					190:194	Khuea	190:194	Khuea	190:194	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	32	with	comparison	241:250	arg1	flour					309:313	commercial rice flour	293:313	commercial rice flour (CMRF)	293:320	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	32	with	comparison	241:250	arg1	JMRF					283:286	JMRF	283:286	JMRF	283:286	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	32	with	comparison	241:250	arg1	flour					276:280	brown Jasmine rice flour	257:280	brown Jasmine rice flour (JMRF)	257:287	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	32	with	comparison	241:250	arg1	CMRF					316:319	CMRF	316:319	CMRF	316:319	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	33	theme	Mod	166:168	arg1	flours					111:116	Thai indigenous brown rice flours	84:116	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand	84:151	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	33	theme	Mod	166:168	arg1	Rin					170:172	Khai Mod Rin	161:172	Khai Mod Rin (KMRF)	161:179	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	33	theme	Mod	166:168	arg1	NKRF					197:200	NKRF	197:200	NKRF	197:200	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	33	theme	Mod	166:168	arg1	KMRF					175:178	KMRF	175:178	KMRF	175:178	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	0	34	theme	physical	10:17	arg1	properties					35:44	Chemical, physical, and functional properties	0:44	Chemical, physical, and functional properties of Thai indigenous brown rice flours	0:81	Chemical, physical, and functional properties of Thai indigenous brown rice flours.
34343208	1	35	theme	commercial	293:302	arg1	flour					309:313	commercial rice flour	293:313	commercial rice flour (CMRF)	293:320	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	35	theme	commercial	293:302	arg1	CMRF					316:319	CMRF	316:319	CMRF	316:319	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	36	theme	indigenous	89:98	arg1	flours					111:116	Thai indigenous brown rice flours	84:116	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand	84:151	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	36	theme	indigenous	89:98	arg1	Rin					170:172	Khai Mod Rin	161:172	Khai Mod Rin (KMRF)	161:179	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	36	theme	indigenous	89:98	arg1	Khuea					190:194	Khuea	190:194	Khuea	190:194	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	0	37	theme	functional	24:33	arg1	properties					35:44	Chemical, physical, and functional properties	0:44	Chemical, physical, and functional properties of Thai indigenous brown rice flours	0:81	Chemical, physical, and functional properties of Thai indigenous brown rice flours.
34343208	1	38	theme	quality	222:228	arg1	aspects					230:236	quality aspects	222:236	quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety	222:344	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	39	theme	rice	304:307	arg1	flour					309:313	commercial rice flour	293:313	commercial rice flour (CMRF)	293:320	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	39	theme	rice	304:307	arg1	CMRF					316:319	CMRF	316:319	CMRF	316:319	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	8	40	theme	lowest	1125:1130	arg1	temperature					1140:1150	the lowest pasting temperature	1121:1150	the lowest pasting temperature	1121:1150	The pasting properties differed among rice flours and the lowest pasting temperature was observed in CMRF.
34343208	9	41	theme	physical	1197:1204	arg1	qualities					1231:1239	the chemical, physical, functional, and pasting qualities	1183:1239	the chemical, physical, functional, and pasting qualities of flours	1183:1249	Overall, the chemical, physical, functional, and pasting qualities of flours were substantially influenced by rice variety.
34343208	2	42	theme	rice	355:358	arg1	flours					360:365	All the rice flours	347:365	All the rice flours	347:365	All the rice flours had different chemical composition, physical characteristic, and techno-functionality.
34343208	8	43	located	observed	1156:1163	arg2	temperature					1140:1150	the lowest pasting temperature	1121:1150	the lowest pasting temperature	1121:1150	The pasting properties differed among rice flours and the lowest pasting temperature was observed in CMRF.
34343208	8	43	located	observed	1156:1163	arg1	CMRF					1168:1171	CMRF	1168:1171	CMRF	1168:1171	The pasting properties differed among rice flours and the lowest pasting temperature was observed in CMRF.
34343208	2	44	contain	had	367:369	arg2	characteristic					412:425	physical characteristic	403:425	physical characteristic	403:425	All the rice flours had different chemical composition, physical characteristic, and techno-functionality.
34343208	2	44	contain	had	367:369	arg2	composition					390:400	different chemical composition	371:400	different chemical composition	371:400	All the rice flours had different chemical composition, physical characteristic, and techno-functionality.
34343208	2	44	contain	had	367:369	arg2	techno-functionality					432:451	techno-functionality	432:451	techno-functionality	432:451	All the rice flours had different chemical composition, physical characteristic, and techno-functionality.
34343208	2	44	contain	had	367:369	arg1	flours					360:365	All the rice flours	347:365	All the rice flours	347:365	All the rice flours had different chemical composition, physical characteristic, and techno-functionality.
34343208	10	45	theme	indigenous	1351:1360	arg1	flour					1367:1371	Thai indigenous rice flour	1346:1371	Thai indigenous rice flour that can be used in food preparations for specific uses	1346:1427	The findings offered fundamental information on Thai indigenous rice flour that can be used in food preparations for specific uses.
34343208	10	46	used	used	1385:1388	arg2	flour					1367:1371	Thai indigenous rice flour	1346:1371	Thai indigenous rice flour that can be used in food preparations for specific uses	1346:1427	The findings offered fundamental information on Thai indigenous rice flour that can be used in food preparations for specific uses.
34343208	2	47	theme	chemical	381:388	arg1	composition					390:400	different chemical composition	371:400	different chemical composition	371:400	All the rice flours had different chemical composition, physical characteristic, and techno-functionality.
34343208	1	48	theme	brown	100:104	arg1	flours					111:116	Thai indigenous brown rice flours	84:116	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand	84:151	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	48	theme	brown	100:104	arg1	Rin					170:172	Khai Mod Rin	161:172	Khai Mod Rin (KMRF)	161:179	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	48	theme	brown	100:104	arg1	Khuea					190:194	Khuea	190:194	Khuea	190:194	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	9	49	theme	pasting	1223:1229	arg1	qualities					1231:1239	the chemical, physical, functional, and pasting qualities	1183:1239	the chemical, physical, functional, and pasting qualities of flours	1183:1249	Overall, the chemical, physical, functional, and pasting qualities of flours were substantially influenced by rice variety.
34343208	4	50	contain	had	552:554	arg2	content					587:593	low total extractable phenolic content	556:593	low total extractable phenolic content (0.1-0.3 mg GAE/g dw)	556:615	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	4	50	contain	had	552:554	arg1	flours					545:550	All rice flours	536:550	All rice flours	536:550	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	4	50	contain	had	552:554	arg2	dw					613:614	0.1-0.3 mg GAE/g dw	596:614	0.1-0.3 mg GAE/g dw	596:614	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	8	51	theme	pasting	1132:1138	arg1	temperature					1140:1150	the lowest pasting temperature	1121:1150	the lowest pasting temperature	1121:1150	The pasting properties differed among rice flours and the lowest pasting temperature was observed in CMRF.
34343208	1	52	theme	rice	106:109	arg1	flours					111:116	Thai indigenous brown rice flours	84:116	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand	84:151	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	52	theme	rice	106:109	arg1	Rin					170:172	Khai Mod Rin	161:172	Khai Mod Rin (KMRF)	161:179	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	52	theme	rice	106:109	arg1	Khuea					190:194	Khuea	190:194	Khuea	190:194	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	7	53	theme	foam	1006:1009	arg1	low					1049:1051	low	1049:1051	low	1049:1051	The foam capacity of the flours was relatively low (1.30-2.60%).
34343208	7	53	theme	foam	1006:1009	arg1	%					1063:1063	1.30-2.60%	1054:1063	1.30-2.60%	1054:1063	The foam capacity of the flours was relatively low (1.30-2.60%).
34343208	7	53	theme	foam	1006:1009	arg1	capacity					1011:1018	The foam capacity	1002:1018	The foam capacity of the flours	1002:1032	The foam capacity of the flours was relatively low (1.30-2.60%).
34343208	4	54	theme	scavenging	633:642	arg1	activity					644:651	some DPPH● scavenging activity	622:651	some DPPH● scavenging activity (38.87-46.77%)	622:666	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	4	54	theme	scavenging	633:642	arg1	%					665:665	38.87-46.77%	654:665	38.87-46.77%	654:665	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	3	55	theme	low	500:502	arg1	type					512:515	a low amylose type	498:515	a low amylose type (19.56-21.25% dw)	498:533	The KMRF, NKRF, and JMRF were classified as a low amylose type (19.56-21.25% dw).
34343208	3	55	theme	low	500:502	arg1	NKRF					464:467	NKRF	464:467	NKRF	464:467	The KMRF, NKRF, and JMRF were classified as a low amylose type (19.56-21.25% dw).
34343208	3	55	theme	low	500:502	arg1	KMRF					458:461	KMRF	458:461	KMRF	458:461	The KMRF, NKRF, and JMRF were classified as a low amylose type (19.56-21.25% dw).
34343208	3	55	theme	low	500:502	arg1	dw					531:532	19.56-21.25% dw	518:532	19.56-21.25% dw	518:532	The KMRF, NKRF, and JMRF were classified as a low amylose type (19.56-21.25% dw).
34343208	3	55	theme	low	500:502	arg1	JMRF					474:477	JMRF	474:477	JMRF	474:477	The KMRF, NKRF, and JMRF were classified as a low amylose type (19.56-21.25% dw).
34343208	5	56	from	variations	673:682	arg1	capacity					740:747	water absorption capacity	723:747	water absorption capacity (0.71-1.17 g/g)	723:763	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	56	from	variations	673:682	arg1	capacity					807:814	oil absorption capacity	792:814	oil absorption capacity (1.39-2.49 g/g)	792:830	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	56	from	variations	673:682	arg1	g/cm3					715:719	1.36-1.83 g/cm3	705:719	1.36-1.83 g/cm3	705:719	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	56	from	variations	673:682	arg1	power					846:850	swelling power	837:850	swelling power (5.71-6.84 g/g)	837:866	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	56	from	variations	673:682	arg1	%					788:788	6.93-13.67%	778:788	6.93-13.67%	778:788	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	56	from	variations	673:682	arg1	g/g					760:762	0.71-1.17 g/g	750:762	0.71-1.17 g/g	750:762	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	56	from	variations	673:682	arg1	g/g					827:829	1.39-2.49 g/g	817:829	1.39-2.49 g/g	817:829	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	56	from	variations	673:682	arg1	density					696:702	the bulk density	687:702	the bulk density (1.36-1.83 g/cm3)	687:720	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	56	from	variations	673:682	arg1	solubility					766:775	solubility	766:775	solubility (6.93-13.67%)	766:789	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	56	from	variations	673:682	arg1	g/g					863:865	5.71-6.84 g/g	853:865	5.71-6.84 g/g	853:865	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	6	57	theme	gelation	895:902	arg1	concentration					904:916	The least gelation concentration	885:916	The least gelation concentration	885:916	The least gelation concentration ranged from 4.0 to 8.0% where KMRF was easier to form gel than JMRF, and NKRF/CMRF.
34343208	4	58	theme	GAE/g	607:611	arg1	dw					613:614	0.1-0.3 mg GAE/g dw	596:614	0.1-0.3 mg GAE/g dw	596:614	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	4	58	theme	GAE/g	607:611	arg1	content					587:593	low total extractable phenolic content	556:593	low total extractable phenolic content (0.1-0.3 mg GAE/g dw)	556:615	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	10	59	dep	specific	1415:1422	arg1	uses					1424:1427	uses	1424:1427	uses	1424:1427	The findings offered fundamental information on Thai indigenous rice flour that can be used in food preparations for specific uses.
34343208	5	60	theme	absorption	729:738	arg1	capacity					740:747	water absorption capacity	723:747	water absorption capacity (0.71-1.17 g/g)	723:763	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	60	theme	absorption	729:738	arg1	g/g					760:762	0.71-1.17 g/g	750:762	0.71-1.17 g/g	750:762	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	3	61	theme	amylose	504:510	arg1	type					512:515	a low amylose type	498:515	a low amylose type (19.56-21.25% dw)	498:533	The KMRF, NKRF, and JMRF were classified as a low amylose type (19.56-21.25% dw).
34343208	3	61	theme	amylose	504:510	arg1	NKRF					464:467	NKRF	464:467	NKRF	464:467	The KMRF, NKRF, and JMRF were classified as a low amylose type (19.56-21.25% dw).
34343208	3	61	theme	amylose	504:510	arg1	KMRF					458:461	KMRF	458:461	KMRF	458:461	The KMRF, NKRF, and JMRF were classified as a low amylose type (19.56-21.25% dw).
34343208	3	61	theme	amylose	504:510	arg1	dw					531:532	19.56-21.25% dw	518:532	19.56-21.25% dw	518:532	The KMRF, NKRF, and JMRF were classified as a low amylose type (19.56-21.25% dw).
34343208	3	61	theme	amylose	504:510	arg1	JMRF					474:477	JMRF	474:477	JMRF	474:477	The KMRF, NKRF, and JMRF were classified as a low amylose type (19.56-21.25% dw).
34343208	4	62	theme	mg	604:605	arg1	dw					613:614	0.1-0.3 mg GAE/g dw	596:614	0.1-0.3 mg GAE/g dw	596:614	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	4	62	theme	mg	604:605	arg1	content					587:593	low total extractable phenolic content	556:593	low total extractable phenolic content (0.1-0.3 mg GAE/g dw)	556:615	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	4	63	theme	phenolic	578:585	arg1	dw					613:614	0.1-0.3 mg GAE/g dw	596:614	0.1-0.3 mg GAE/g dw	596:614	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	4	63	theme	phenolic	578:585	arg1	content					587:593	low total extractable phenolic content	556:593	low total extractable phenolic content (0.1-0.3 mg GAE/g dw)	556:615	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	0	64	theme	indigenous	54:63	arg1	flours					76:81	Thai indigenous brown rice flours	49:81	Thai indigenous brown rice flours	49:81	Chemical, physical, and functional properties of Thai indigenous brown rice flours.
34343208	1	65	theme	Chai	327:330	arg1	variety					338:344	Chai Nat 1 variety	327:344	Chai Nat 1 variety	327:344	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	5	66	theme	absorption	796:805	arg1	capacity					807:814	oil absorption capacity	792:814	oil absorption capacity (1.39-2.49 g/g)	792:830	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	5	66	theme	absorption	796:805	arg1	g/g					827:829	1.39-2.49 g/g	817:829	1.39-2.49 g/g	817:829	The variations in the bulk density (1.36-1.83 g/cm3), water absorption capacity (0.71-1.17 g/g), solubility (6.93-13.67%), oil absorption capacity (1.39-2.49 g/g), and swelling power (5.71-6.84 g/g) were noticeable.
34343208	9	67	theme	chemical	1187:1194	arg1	qualities					1231:1239	the chemical, physical, functional, and pasting qualities	1183:1239	the chemical, physical, functional, and pasting qualities of flours	1183:1249	Overall, the chemical, physical, functional, and pasting qualities of flours were substantially influenced by rice variety.
34343208	1	68	from	variety	338:344	arg1	flour					309:313	commercial rice flour	293:313	commercial rice flour (CMRF)	293:320	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	68	from	variety	338:344	arg1	JMRF					283:286	JMRF	283:286	JMRF	283:286	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	68	from	variety	338:344	arg1	flour					276:280	brown Jasmine rice flour	257:280	brown Jasmine rice flour (JMRF)	257:287	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	68	from	variety	338:344	arg1	CMRF					316:319	CMRF	316:319	CMRF	316:319	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	0	69	theme	Thai	49:52	arg1	flours					76:81	Thai indigenous brown rice flours	49:81	Thai indigenous brown rice flours	49:81	Chemical, physical, and functional properties of Thai indigenous brown rice flours.
34343208	1	70	theme	brown	257:261	arg1	JMRF					283:286	JMRF	283:286	JMRF	283:286	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	70	theme	brown	257:261	arg1	flour					276:280	brown Jasmine rice flour	257:280	brown Jasmine rice flour (JMRF)	257:287	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	7	71	theme	flours	1027:1032	arg1	low					1049:1051	low	1049:1051	low	1049:1051	The foam capacity of the flours was relatively low (1.30-2.60%).
34343208	7	71	theme	flours	1027:1032	arg1	%					1063:1063	1.30-2.60%	1054:1063	1.30-2.60%	1054:1063	The foam capacity of the flours was relatively low (1.30-2.60%).
34343208	7	71	theme	flours	1027:1032	arg1	capacity					1011:1018	The foam capacity	1002:1018	The foam capacity of the flours	1002:1032	The foam capacity of the flours was relatively low (1.30-2.60%).
34343208	1	72	from	Thailand	144:151	arg1	flours					111:116	Thai indigenous brown rice flours	84:116	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand	84:151	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	72	from	Thailand	144:151	arg1	Rin					170:172	Khai Mod Rin	161:172	Khai Mod Rin (KMRF)	161:179	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	1	72	from	Thailand	144:151	arg1	Khuea					190:194	Khuea	190:194	Khuea	190:194	Thai indigenous brown rice flours from Nakhon Si Thammarat, Thailand, namely Khai Mod Rin (KMRF) and Noui Khuea (NKRF), were assessed for quality aspects in comparison with brown Jasmine rice flour (JMRF) and commercial rice flour (CMRF) from Chai Nat 1 variety.
34343208	4	73	theme	rice	540:543	arg1	flours					545:550	All rice flours	536:550	All rice flours	536:550	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	10	74	theme	rice	1362:1365	arg1	flour					1367:1371	Thai indigenous rice flour	1346:1371	Thai indigenous rice flour that can be used in food preparations for specific uses	1346:1427	The findings offered fundamental information on Thai indigenous rice flour that can be used in food preparations for specific uses.
34343208	4	75	theme	total	560:564	arg1	dw					613:614	0.1-0.3 mg GAE/g dw	596:614	0.1-0.3 mg GAE/g dw	596:614	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
34343208	4	75	theme	total	560:564	arg1	content					587:593	low total extractable phenolic content	556:593	low total extractable phenolic content (0.1-0.3 mg GAE/g dw)	556:615	All rice flours had low total extractable phenolic content (0.1-0.3 mg GAE/g dw) with some DPPH● scavenging activity (38.87-46.77%).
33259988	7	0	theme	factor	987:992	arg1	activator					925:933	the receptor activator	912:933	the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10	912:1032	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	14	1	theme	IL-10	1760:1764	arg1	expression					1739:1748	distinctive expression	1727:1748	distinctive expression of TNF-α, IL-10, and IL-17	1727:1775	CONCLUSION LPS, PGN, or LPS + PGN injections induce distinctive expression of TNF-α, IL-10, and IL-17, suggesting that the composition of these bacterial ligands in dental plaque is critical for alveolar bone resorption.
33259988	4	2	theme	bone	603:606	arg1	resorption					608:617	the alveolar bone resorption	590:617	the alveolar bone resorption induced by LPS and PGN	590:640	The aim of this study is to clarify the role of osteoclastogenic and anti-osteoclastogenic cytokines in the alveolar bone resorption induced by LPS and PGN.
33259988	8	3	theme	cytokines	1096:1104	arg1	role					1082:1085	the role	1078:1085	the role of these cytokines	1078:1104	To analyze the role of these cytokines, RANKL-pretreated mouse bone marrow macrophages were stimulated with LPS, PGN, or LPS + PGN with or without anti-TNF-α antibody, IL-17, or IL-10.
33259988	6	4	theme	bone	804:807	arg1	resorption					809:818	Alveolar bone resorption	795:818	Alveolar bone resorption	795:818	Alveolar bone resorption was assessed histochemically by tartrate-resistant acid phosphatase staining.
33259988	1	5	theme	subgingival	184:194	arg1	biofilm					196:202	subgingival biofilm	184:202	subgingival biofilm	184:202	OBJECTIVE Bacterial substances in subgingival biofilm evoke alveolar bone resorption.
33259988	4	6	theme	alveolar	594:601	arg1	resorption					608:617	the alveolar bone resorption	590:617	the alveolar bone resorption induced by LPS and PGN	590:640	The aim of this study is to clarify the role of osteoclastogenic and anti-osteoclastogenic cytokines in the alveolar bone resorption induced by LPS and PGN.
33259988	8	7	theme	mouse	1124:1128	arg1	macrophages					1142:1152	RANKL-pretreated mouse bone marrow macrophages	1107:1152	RANKL-pretreated mouse bone marrow macrophages	1107:1152	To analyze the role of these cytokines, RANKL-pretreated mouse bone marrow macrophages were stimulated with LPS, PGN, or LPS + PGN with or without anti-TNF-α antibody, IL-17, or IL-10.
33259988	6	8	theme	Alveolar	795:802	arg1	resorption					809:818	Alveolar bone resorption	795:818	Alveolar bone resorption	795:818	Alveolar bone resorption was assessed histochemically by tartrate-resistant acid phosphatase staining.
33259988	2	9	theme	peptidoglycan	325:337	arg1	injection					273:281	gingival injection	264:281	gingival injection of bacterial lipopolysaccharide (LPS) and peptidoglycan (PGN)	264:343	We previously reported that gingival injection of bacterial lipopolysaccharide (LPS) and peptidoglycan (PGN) induced alveolar bone resorption in mice.
33259988	11	10	theme	bone	1443:1446	arg1	resorption					1448:1457	bone resorption	1443:1457	bone resorption	1443:1457	Expression of TNF-α and IL-10 was correlated with bone resorption.
33259988	8	11	theme	RANKL-pretreated	1107:1122	arg1	macrophages					1142:1152	RANKL-pretreated mouse bone marrow macrophages	1107:1152	RANKL-pretreated mouse bone marrow macrophages	1107:1152	To analyze the role of these cytokines, RANKL-pretreated mouse bone marrow macrophages were stimulated with LPS, PGN, or LPS + PGN with or without anti-TNF-α antibody, IL-17, or IL-10.
33259988	14	12	theme	distinctive	1727:1737	arg1	expression					1739:1748	distinctive expression	1727:1748	distinctive expression of TNF-α, IL-10, and IL-17	1727:1775	CONCLUSION LPS, PGN, or LPS + PGN injections induce distinctive expression of TNF-α, IL-10, and IL-17, suggesting that the composition of these bacterial ligands in dental plaque is critical for alveolar bone resorption.
33259988	10	13	theme	RANKL	1366:1370	arg1	expression					1372:1381	higher RANKL expression	1359:1381	higher RANKL expression	1359:1381	LPS induced higher RANKL expression than PGN.
33259988	13	14	dep	in	1555:1556	arg1	vitro					1558:1562	vitro	1558:1562	vitro	1558:1562	In an in vitro osteoclastogenesis assay, anti-TNF-α antibody and IL-10 inhibited osteoclast formation, but IL-17 promoted it.
33259988	2	15	theme	alveolar	353:360	arg1	resorption					367:376	alveolar bone resorption	353:376	alveolar bone resorption	353:376	We previously reported that gingival injection of bacterial lipopolysaccharide (LPS) and peptidoglycan (PGN) induced alveolar bone resorption in mice.
33259988	8	16	theme	marrow	1135:1140	arg1	macrophages					1142:1152	RANKL-pretreated mouse bone marrow macrophages	1107:1152	RANKL-pretreated mouse bone marrow macrophages	1107:1152	To analyze the role of these cytokines, RANKL-pretreated mouse bone marrow macrophages were stimulated with LPS, PGN, or LPS + PGN with or without anti-TNF-α antibody, IL-17, or IL-10.
33259988	9	17	theme	RESULTS	1252:1258	arg1	resorption					1274:1283	RESULTS Alveolar bone resorption	1252:1283	RESULTS Alveolar bone resorption	1252:1283	RESULTS Alveolar bone resorption was induced by both LPS and PGN and exacerbated by LPS + PGN.
33259988	1	18	from	substances	170:179	arg1	biofilm					196:202	subgingival biofilm	184:202	subgingival biofilm	184:202	OBJECTIVE Bacterial substances in subgingival biofilm evoke alveolar bone resorption.
33259988	1	19	theme	alveolar	210:217	arg1	resorption					224:233	alveolar bone resorption	210:233	alveolar bone resorption	210:233	OBJECTIVE Bacterial substances in subgingival biofilm evoke alveolar bone resorption.
33259988	14	20	theme	dental	1840:1845	arg1	plaque					1847:1852	dental plaque	1840:1852	dental plaque	1840:1852	CONCLUSION LPS, PGN, or LPS + PGN injections induce distinctive expression of TNF-α, IL-10, and IL-17, suggesting that the composition of these bacterial ligands in dental plaque is critical for alveolar bone resorption.
33259988	5	21	dep	MATERIALS	643:651	arg1	LPS					653:655	LPS	653:655	LPS from Escherichia coli	653:677	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	5	21	dep	MATERIALS	643:651	arg1	both					715:718	both	715:718	both	715:718	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	5	21	dep	MATERIALS	643:651	arg1	MATERIALS					643:651	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both	643:718	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both	643:718	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	5	21	dep	MATERIALS	643:651	arg1	PGN					680:682	PGN	680:682	PGN from Staphylococcus aureus	680:709	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	4	22	theme	study	502:506	arg1	aim					490:492	The aim	486:492	The aim of this study	486:506	The aim of this study is to clarify the role of osteoclastogenic and anti-osteoclastogenic cytokines in the alveolar bone resorption induced by LPS and PGN.
33259988	7	23	theme	ligand	956:961	arg1	activator					925:933	the receptor activator	912:933	the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10	912:1032	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	14	24	theme	IL-17	1771:1775	arg1	expression					1739:1748	distinctive expression	1727:1748	distinctive expression of TNF-α, IL-10, and IL-17	1727:1775	CONCLUSION LPS, PGN, or LPS + PGN injections induce distinctive expression of TNF-α, IL-10, and IL-17, suggesting that the composition of these bacterial ligands in dental plaque is critical for alveolar bone resorption.
33259988	5	25	theme	times	788:792	arg1	total					776:780	a total	774:780	a total of 13 times	774:792	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	9	26	theme	bone	1269:1272	arg1	resorption					1274:1283	RESULTS Alveolar bone resorption	1252:1283	RESULTS Alveolar bone resorption	1252:1283	RESULTS Alveolar bone resorption was induced by both LPS and PGN and exacerbated by LPS + PGN.
33259988	14	27	theme	TNF-α	1753:1757	arg1	expression					1739:1748	distinctive expression	1727:1748	distinctive expression of TNF-α, IL-10, and IL-17	1727:1775	CONCLUSION LPS, PGN, or LPS + PGN injections induce distinctive expression of TNF-α, IL-10, and IL-17, suggesting that the composition of these bacterial ligands in dental plaque is critical for alveolar bone resorption.
33259988	14	28	theme	alveolar	1870:1877	arg1	resorption					1884:1893	alveolar bone resorption	1870:1893	alveolar bone resorption	1870:1893	CONCLUSION LPS, PGN, or LPS + PGN injections induce distinctive expression of TNF-α, IL-10, and IL-17, suggesting that the composition of these bacterial ligands in dental plaque is critical for alveolar bone resorption.
33259988	13	29	theme	in	1555:1556	arg1	assay					1583:1587	an in vitro osteoclastogenesis assay	1552:1587	an in vitro osteoclastogenesis assay	1552:1587	In an in vitro osteoclastogenesis assay, anti-TNF-α antibody and IL-10 inhibited osteoclast formation, but IL-17 promoted it.
33259988	3	30	theme	osteoclast	438:447	arg1	formation					449:457	osteoclast formation	438:457	osteoclast formation	438:457	However, the mechanism by which LPS and PGN induce osteoclast formation has not been investigated.
33259988	13	31	theme	anti-TNF-α	1590:1599	arg1	antibody					1601:1608	anti-TNF-α antibody	1590:1608	anti-TNF-α antibody	1590:1608	In an in vitro osteoclastogenesis assay, anti-TNF-α antibody and IL-10 inhibited osteoclast formation, but IL-17 promoted it.
33259988	4	32	theme	cytokines	577:585	arg1	role					526:529	the role	522:529	the role of osteoclastogenic and anti-osteoclastogenic cytokines in the alveolar bone resorption induced by LPS and PGN	522:640	The aim of this study is to clarify the role of osteoclastogenic and anti-osteoclastogenic cytokines in the alveolar bone resorption induced by LPS and PGN.
33259988	13	33	theme	osteoclast	1630:1639	arg1	formation					1641:1649	osteoclast formation	1630:1649	osteoclast formation	1630:1649	In an in vitro osteoclastogenesis assay, anti-TNF-α antibody and IL-10 inhibited osteoclast formation, but IL-17 promoted it.
33259988	7	34	theme	nuclear	938:944	arg1	ligand					956:961	nuclear factor-κB ligand	938:961	nuclear factor-κB ligand (RANKL)	938:969	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	7	34	theme	nuclear	938:944	arg1	RANKL					964:968	RANKL	964:968	RANKL	964:968	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	14	35	from	composition	1798:1808	arg1	plaque					1847:1852	dental plaque	1840:1852	dental plaque	1840:1852	CONCLUSION LPS, PGN, or LPS + PGN injections induce distinctive expression of TNF-α, IL-10, and IL-17, suggesting that the composition of these bacterial ligands in dental plaque is critical for alveolar bone resorption.
33259988	1	36	theme	bone	219:222	arg1	resorption					224:233	alveolar bone resorption	210:233	alveolar bone resorption	210:233	OBJECTIVE Bacterial substances in subgingival biofilm evoke alveolar bone resorption.
33259988	14	37	theme	ligands	1829:1835	arg1	critical					1857:1864	critical	1857:1864	critical	1857:1864	CONCLUSION LPS, PGN, or LPS + PGN injections induce distinctive expression of TNF-α, IL-10, and IL-17, suggesting that the composition of these bacterial ligands in dental plaque is critical for alveolar bone resorption.
33259988	14	37	theme	ligands	1829:1835	arg1	composition					1798:1808	the composition	1794:1808	the composition of these bacterial ligands in dental plaque	1794:1852	CONCLUSION LPS, PGN, or LPS + PGN injections induce distinctive expression of TNF-α, IL-10, and IL-17, suggesting that the composition of these bacterial ligands in dental plaque is critical for alveolar bone resorption.
33259988	4	38	theme	anti-osteoclastogenic	555:575	arg1	cytokines					577:585	osteoclastogenic and anti-osteoclastogenic cytokines	534:585	osteoclastogenic and anti-osteoclastogenic cytokines	534:585	The aim of this study is to clarify the role of osteoclastogenic and anti-osteoclastogenic cytokines in the alveolar bone resorption induced by LPS and PGN.
33259988	5	39	dep	48 h	765:768	arg1	every					759:763	every	759:763	every	759:763	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	7	40	theme	factor-κB	946:954	arg1	ligand					956:961	nuclear factor-κB ligand	938:961	nuclear factor-κB ligand (RANKL)	938:969	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	7	40	theme	factor-κB	946:954	arg1	RANKL					964:968	RANKL	964:968	RANKL	964:968	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	11	41	theme	TNF-α	1407:1411	arg1	Expression					1393:1402	Expression	1393:1402	Expression of TNF-α and IL-10	1393:1421	Expression of TNF-α and IL-10 was correlated with bone resorption.
33259988	8	42	theme	anti-TNF-α	1214:1223	arg1	antibody					1225:1232	anti-TNF-α antibody	1214:1232	anti-TNF-α antibody	1214:1232	To analyze the role of these cytokines, RANKL-pretreated mouse bone marrow macrophages were stimulated with LPS, PGN, or LPS + PGN with or without anti-TNF-α antibody, IL-17, or IL-10.
33259988	0	43	theme	osteoclastogenic	14:29	arg1	cytokines					57:65	osteoclastogenic and anti-osteoclastogenic cytokines	14:65	osteoclastogenic and anti-osteoclastogenic cytokines	14:65	Expression of osteoclastogenic and anti-osteoclastogenic cytokines differs in mouse gingiva injected with lipopolysaccharide, peptidoglycan, or both.
33259988	6	44	theme	phosphatase	876:886	arg1	staining					888:895	tartrate-resistant acid phosphatase staining	852:895	tartrate-resistant acid phosphatase staining	852:895	Alveolar bone resorption was assessed histochemically by tartrate-resistant acid phosphatase staining.
33259988	0	45	theme	cytokines	57:65	arg1	Expression					0:9	Expression	0:9	Expression of osteoclastogenic and anti-osteoclastogenic cytokines	0:65	Expression of osteoclastogenic and anti-osteoclastogenic cytokines differs in mouse gingiva injected with lipopolysaccharide, peptidoglycan, or both.
33259988	9	46	theme	Alveolar	1260:1267	arg1	resorption					1274:1283	RESULTS Alveolar bone resorption	1252:1283	RESULTS Alveolar bone resorption	1252:1283	RESULTS Alveolar bone resorption was induced by both LPS and PGN and exacerbated by LPS + PGN.
33259988	5	47	dep	mice	754:757	arg1	48 h					765:768	48 h	765:768	48 h	765:768	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	6	48	theme	acid	871:874	arg1	phosphatase					876:886	tartrate-resistant acid phosphatase	852:886	tartrate-resistant acid phosphatase staining	852:895	Alveolar bone resorption was assessed histochemically by tartrate-resistant acid phosphatase staining.
33259988	11	49	theme	IL-10	1417:1421	arg1	Expression					1393:1402	Expression	1393:1402	Expression of TNF-α and IL-10	1393:1421	Expression of TNF-α and IL-10 was correlated with bone resorption.
33259988	14	50	theme	bacterial	1819:1827	arg1	ligands					1829:1835	these bacterial ligands	1813:1835	these bacterial ligands	1813:1835	CONCLUSION LPS, PGN, or LPS + PGN injections induce distinctive expression of TNF-α, IL-10, and IL-17, suggesting that the composition of these bacterial ligands in dental plaque is critical for alveolar bone resorption.
33259988	0	51	theme	anti-osteoclastogenic	35:55	arg1	cytokines					57:65	osteoclastogenic and anti-osteoclastogenic cytokines	14:65	osteoclastogenic and anti-osteoclastogenic cytokines	14:65	Expression of osteoclastogenic and anti-osteoclastogenic cytokines differs in mouse gingiva injected with lipopolysaccharide, peptidoglycan, or both.
33259988	12	52	theme	PGN	1460:1462	arg1	injections					1464:1473	PGN injections	1460:1473	PGN injections	1460:1473	PGN injections induced the strongest expression of IL-17, followed by LPS + PGN and LPS.
33259988	6	53	theme	tartrate-resistant	852:869	arg1	phosphatase					876:886	tartrate-resistant acid phosphatase	852:886	tartrate-resistant acid phosphatase staining	852:895	Alveolar bone resorption was assessed histochemically by tartrate-resistant acid phosphatase staining.
33259988	2	54	theme	gingival	264:271	arg1	injection					273:281	gingival injection	264:281	gingival injection of bacterial lipopolysaccharide (LPS) and peptidoglycan (PGN)	264:343	We previously reported that gingival injection of bacterial lipopolysaccharide (LPS) and peptidoglycan (PGN) induced alveolar bone resorption in mice.
33259988	5	55	from	coli	674:677	arg1	LPS					653:655	LPS	653:655	LPS from Escherichia coli	653:677	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	5	55	from	coli	674:677	arg1	MATERIALS					643:651	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both	643:718	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both	643:718	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	5	55	from	coli	674:677	arg1	PGN					680:682	PGN	680:682	PGN from Staphylococcus aureus	680:709	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	8	56	theme	bone	1130:1133	arg1	macrophages					1142:1152	RANKL-pretreated mouse bone marrow macrophages	1107:1152	RANKL-pretreated mouse bone marrow macrophages	1107:1152	To analyze the role of these cytokines, RANKL-pretreated mouse bone marrow macrophages were stimulated with LPS, PGN, or LPS + PGN with or without anti-TNF-α antibody, IL-17, or IL-10.
33259988	14	57	theme	bone	1879:1882	arg1	resorption					1884:1893	alveolar bone resorption	1870:1893	alveolar bone resorption	1870:1893	CONCLUSION LPS, PGN, or LPS + PGN injections induce distinctive expression of TNF-α, IL-10, and IL-17, suggesting that the composition of these bacterial ligands in dental plaque is critical for alveolar bone resorption.
33259988	7	58	theme	interleukin	1003:1013	arg1	IL					1016:1017	interleukin (IL)-17	1003:1021	interleukin (IL)-17	1003:1021	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	4	59	from	role	526:529	arg1	resorption					608:617	the alveolar bone resorption	590:617	the alveolar bone resorption induced by LPS and PGN	590:640	The aim of this study is to clarify the role of osteoclastogenic and anti-osteoclastogenic cytokines in the alveolar bone resorption induced by LPS and PGN.
33259988	14	60	theme	LPS + PGN	1699:1707	arg1	injections					1709:1718	LPS + PGN injections	1699:1718	LPS + PGN injections	1699:1718	CONCLUSION LPS, PGN, or LPS + PGN injections induce distinctive expression of TNF-α, IL-10, and IL-17, suggesting that the composition of these bacterial ligands in dental plaque is critical for alveolar bone resorption.
33259988	7	61	theme	IL-10	1028:1032	arg1	activator					925:933	the receptor activator	912:933	the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10	912:1032	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	13	62	theme	osteoclastogenesis	1564:1581	arg1	assay					1583:1587	an in vitro osteoclastogenesis assay	1552:1587	an in vitro osteoclastogenesis assay	1552:1587	In an in vitro osteoclastogenesis assay, anti-TNF-α antibody and IL-10 inhibited osteoclast formation, but IL-17 promoted it.
33259988	7	63	theme	activator	925:933	arg1	Expression					898:907	Expression	898:907	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10	898:1032	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	4	64	theme	osteoclastogenic	534:549	arg1	cytokines					577:585	osteoclastogenic and anti-osteoclastogenic cytokines	534:585	osteoclastogenic and anti-osteoclastogenic cytokines	534:585	The aim of this study is to clarify the role of osteoclastogenic and anti-osteoclastogenic cytokines in the alveolar bone resorption induced by LPS and PGN.
33259988	10	65	theme	higher	1359:1364	arg1	expression					1372:1381	higher RANKL expression	1359:1381	higher RANKL expression	1359:1381	LPS induced higher RANKL expression than PGN.
33259988	7	66	theme	tumor	972:976	arg1	TNF					995:997	TNF	995:997	TNF	995:997	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	7	66	theme	tumor	972:976	arg1	factor					987:992	tumor necrosis factor (TNF)-α	972:1000	tumor necrosis factor (TNF)-α	972:1000	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	2	67	theme	bone	362:365	arg1	resorption					367:376	alveolar bone resorption	353:376	alveolar bone resorption	353:376	We previously reported that gingival injection of bacterial lipopolysaccharide (LPS) and peptidoglycan (PGN) induced alveolar bone resorption in mice.
33259988	5	68	from	aureus	704:709	arg1	LPS					653:655	LPS	653:655	LPS from Escherichia coli	653:677	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	5	68	from	aureus	704:709	arg1	MATERIALS					643:651	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both	643:718	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both	643:718	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	5	68	from	aureus	704:709	arg1	PGN					680:682	PGN	680:682	PGN from Staphylococcus aureus	680:709	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	7	69	theme	IL	1016:1017	arg1	activator					925:933	the receptor activator	912:933	the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10	912:1032	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	2	70	theme	lipopolysaccharide	296:313	arg1	injection					273:281	gingival injection	264:281	gingival injection of bacterial lipopolysaccharide (LPS) and peptidoglycan (PGN)	264:343	We previously reported that gingival injection of bacterial lipopolysaccharide (LPS) and peptidoglycan (PGN) induced alveolar bone resorption in mice.
33259988	1	71	theme	OBJECTIVE	150:158	arg1	substances					170:179	OBJECTIVE Bacterial substances	150:179	OBJECTIVE Bacterial substances in subgingival biofilm	150:202	OBJECTIVE Bacterial substances in subgingival biofilm evoke alveolar bone resorption.
33259988	12	72	theme	strongest	1487:1495	arg1	expression					1497:1506	the strongest expression	1483:1506	the strongest expression of IL-17	1483:1515	PGN injections induced the strongest expression of IL-17, followed by LPS + PGN and LPS.
33259988	5	73	theme	mice	754:757	arg1	gingiva					743:749	the gingiva	739:749	the gingiva of mice every 48 h for a total of 13 times	739:792	MATERIALS LPS from Escherichia coli, PGN from Staphylococcus aureus, or both were injected into the gingiva of mice every 48 h for a total of 13 times.
33259988	2	74	theme	bacterial	286:294	arg1	LPS					316:318	LPS	316:318	LPS	316:318	We previously reported that gingival injection of bacterial lipopolysaccharide (LPS) and peptidoglycan (PGN) induced alveolar bone resorption in mice.
33259988	2	74	theme	bacterial	286:294	arg1	lipopolysaccharide					296:313	bacterial lipopolysaccharide	286:313	bacterial lipopolysaccharide (LPS)	286:319	We previously reported that gingival injection of bacterial lipopolysaccharide (LPS) and peptidoglycan (PGN) induced alveolar bone resorption in mice.
33259988	1	75	theme	Bacterial	160:168	arg1	substances					170:179	OBJECTIVE Bacterial substances	150:179	OBJECTIVE Bacterial substances in subgingival biofilm	150:202	OBJECTIVE Bacterial substances in subgingival biofilm evoke alveolar bone resorption.
33259988	7	76	theme	receptor	916:923	arg1	activator					925:933	the receptor activator	912:933	the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10	912:1032	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	12	77	theme	IL-17	1511:1515	arg1	expression					1497:1506	the strongest expression	1483:1506	the strongest expression of IL-17	1483:1515	PGN injections induced the strongest expression of IL-17, followed by LPS + PGN and LPS.
33259988	0	78	theme	mouse	78:82	arg1	gingiva					84:90	mouse gingiva	78:90	mouse gingiva injected with lipopolysaccharide, peptidoglycan, or both	78:147	Expression of osteoclastogenic and anti-osteoclastogenic cytokines differs in mouse gingiva injected with lipopolysaccharide, peptidoglycan, or both.
33259988	14	79	dep	CONCLUSION	1675:1684	arg1	LPS					1686:1688	LPS	1686:1688	LPS	1686:1688	CONCLUSION LPS, PGN, or LPS + PGN injections induce distinctive expression of TNF-α, IL-10, and IL-17, suggesting that the composition of these bacterial ligands in dental plaque is critical for alveolar bone resorption.
33259988	7	80	theme	necrosis	978:985	arg1	TNF					995:997	TNF	995:997	TNF	995:997	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
33259988	7	80	theme	necrosis	978:985	arg1	factor					987:992	tumor necrosis factor (TNF)-α	972:1000	tumor necrosis factor (TNF)-α	972:1000	Expression of the receptor activator of nuclear factor-κB ligand (RANKL), tumor necrosis factor (TNF)-α, interleukin (IL)-17, and IL-10 were analyzed by immunostaining.
32507169	0	0	theme	water-in-oil	81:92	arg1	emulsion					94:101	water-in-oil emulsion	81:101	water-in-oil emulsion separation	81:112	The change from hydrophilicity to hydrophobicity of HEC/PAA complex membrane for water-in-oil emulsion separation: Thermal versus chemical treatment.
32507169	5	1	theme	different	1098:1106	arg1	concentrations					1108:1121	different concentrations	1098:1121	different concentrations	1098:1121	When the membranes are applied as oil filters to treat water-in-oil emulsions with different concentrations, both of the modified membranes show excellent separation efficiencies with a more than 99.4% rejection for all tested water-in-oil emulsions.
32507169	4	2	theme	surface	833:839	arg1	morphology					841:850	surface morphology	833:850	surface morphology	833:850	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	3	3	theme	post-treatment	626:639	arg1	methods					641:647	two post-treatment methods	622:647	two post-treatment methods	622:647	In order to obtain a hydrophobic surface, two post-treatment methods, thermally and chemically induced cross-linking, are applied to modify the hydrogen-bonded HEC/PAA complex membrane.
32507169	3	3	theme	post-treatment	626:639	arg1	cross-linking					683:695	cross-linking	683:695	thermally and chemically induced cross-linking	650:695	In order to obtain a hydrophobic surface, two post-treatment methods, thermally and chemically induced cross-linking, are applied to modify the hydrogen-bonded HEC/PAA complex membrane.
32507169	2	4	theme	hydroxyethyl	350:361	arg1	cellulose					363:371	hydroxyethyl cellulose	350:371	hydroxyethyl cellulose (HEC)	350:377	In this work, hydroxyethyl cellulose (HEC) and poly(acrylic acid) (PAA) are selected to form a complex membrane on the surface of poly(ethylene terephthalate) (PET) nonwoven via layer-by-layer assembly for separation of water-in-oil emulsions.
32507169	2	4	theme	hydroxyethyl	350:361	arg1	HEC					374:376	HEC	374:376	HEC	374:376	In this work, hydroxyethyl cellulose (HEC) and poly(acrylic acid) (PAA) are selected to form a complex membrane on the surface of poly(ethylene terephthalate) (PET) nonwoven via layer-by-layer assembly for separation of water-in-oil emulsions.
32507169	5	5	theme	tested	1235:1240	arg1	emulsions					1255:1263	all tested water-in-oil emulsions	1231:1263	all tested water-in-oil emulsions	1231:1263	When the membranes are applied as oil filters to treat water-in-oil emulsions with different concentrations, both of the modified membranes show excellent separation efficiencies with a more than 99.4% rejection for all tested water-in-oil emulsions.
32507169	2	6	theme	ethylene	471:478	arg1	poly					466:469	poly	466:469	poly(ethylene terephthalate) (PET) nonwoven via layer-by-layer assembly for separation of water-in-oil emulsions	466:577	In this work, hydroxyethyl cellulose (HEC) and poly(acrylic acid) (PAA) are selected to form a complex membrane on the surface of poly(ethylene terephthalate) (PET) nonwoven via layer-by-layer assembly for separation of water-in-oil emulsions.
32507169	2	6	theme	ethylene	471:478	arg1	terephthalate					480:492	ethylene terephthalate	471:492	ethylene terephthalate	471:492	In this work, hydroxyethyl cellulose (HEC) and poly(acrylic acid) (PAA) are selected to form a complex membrane on the surface of poly(ethylene terephthalate) (PET) nonwoven via layer-by-layer assembly for separation of water-in-oil emulsions.
32507169	5	7	theme	water-in-oil	1242:1253	arg1	emulsions					1255:1263	all tested water-in-oil emulsions	1231:1263	all tested water-in-oil emulsions	1231:1263	When the membranes are applied as oil filters to treat water-in-oil emulsions with different concentrations, both of the modified membranes show excellent separation efficiencies with a more than 99.4% rejection for all tested water-in-oil emulsions.
32507169	0	8	theme	emulsion	94:101	arg1	separation					103:112	water-in-oil emulsion separation	81:112	water-in-oil emulsion separation	81:112	The change from hydrophilicity to hydrophobicity of HEC/PAA complex membrane for water-in-oil emulsion separation: Thermal versus chemical treatment.
32507169	3	9	theme	induced	675:681	arg1	methods					641:647	two post-treatment methods	622:647	two post-treatment methods	622:647	In order to obtain a hydrophobic surface, two post-treatment methods, thermally and chemically induced cross-linking, are applied to modify the hydrogen-bonded HEC/PAA complex membrane.
32507169	3	9	theme	induced	675:681	arg1	cross-linking					683:695	cross-linking	683:695	thermally and chemically induced cross-linking	650:695	In order to obtain a hydrophobic surface, two post-treatment methods, thermally and chemically induced cross-linking, are applied to modify the hydrogen-bonded HEC/PAA complex membrane.
32507169	2	10	theme	poly	466:469	arg1	surface					455:461	the surface	451:461	the surface of poly(ethylene terephthalate) (PET) nonwoven via layer-by-layer assembly for separation of water-in-oil emulsions	451:577	In this work, hydroxyethyl cellulose (HEC) and poly(acrylic acid) (PAA) are selected to form a complex membrane on the surface of poly(ethylene terephthalate) (PET) nonwoven via layer-by-layer assembly for separation of water-in-oil emulsions.
32507169	4	11	theme	HEC/PAA-PET	800:810	arg1	stability					903:911	thermal stability	895:911	thermal stability	895:911	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	11	theme	HEC/PAA-PET	800:810	arg1	membranes					812:820	the two treated HEC/PAA-PET membranes	784:820	the two treated HEC/PAA-PET membranes	784:820	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	11	theme	HEC/PAA-PET	800:810	arg1	wettability					948:958	membrane wettability	939:958	membrane wettability	939:958	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	11	theme	HEC/PAA-PET	800:810	arg1	structure					862:870	chemical structure	853:870	chemical structure	853:870	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	11	theme	HEC/PAA-PET	800:810	arg1	property					925:932	mechanical property	914:932	mechanical property	914:932	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	11	theme	HEC/PAA-PET	800:810	arg1	morphology					841:850	surface morphology	833:850	surface morphology	833:850	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	11	theme	HEC/PAA-PET	800:810	arg1	composition					882:892	chemical composition	873:892	chemical composition	873:892	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	5	12	theme	water-in-oil	1070:1081	arg1	emulsions					1083:1091	water-in-oil emulsions	1070:1091	water-in-oil emulsions	1070:1091	When the membranes are applied as oil filters to treat water-in-oil emulsions with different concentrations, both of the modified membranes show excellent separation efficiencies with a more than 99.4% rejection for all tested water-in-oil emulsions.
32507169	4	13	theme	treated	792:798	arg1	stability					903:911	thermal stability	895:911	thermal stability	895:911	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	13	theme	treated	792:798	arg1	membranes					812:820	the two treated HEC/PAA-PET membranes	784:820	the two treated HEC/PAA-PET membranes	784:820	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	13	theme	treated	792:798	arg1	wettability					948:958	membrane wettability	939:958	membrane wettability	939:958	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	13	theme	treated	792:798	arg1	structure					862:870	chemical structure	853:870	chemical structure	853:870	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	13	theme	treated	792:798	arg1	property					925:932	mechanical property	914:932	mechanical property	914:932	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	13	theme	treated	792:798	arg1	morphology					841:850	surface morphology	833:850	surface morphology	833:850	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	13	theme	treated	792:798	arg1	composition					882:892	chemical composition	873:892	chemical composition	873:892	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	0	14	theme	Thermal	115:121	arg1	treatment					139:147	Thermal versus chemical treatment	115:147	Thermal versus chemical treatment	115:147	The change from hydrophilicity to hydrophobicity of HEC/PAA complex membrane for water-in-oil emulsion separation: Thermal versus chemical treatment.
32507169	2	15	theme	emulsions	569:577	arg1	separation					542:551	separation	542:551	separation of water-in-oil emulsions	542:577	In this work, hydroxyethyl cellulose (HEC) and poly(acrylic acid) (PAA) are selected to form a complex membrane on the surface of poly(ethylene terephthalate) (PET) nonwoven via layer-by-layer assembly for separation of water-in-oil emulsions.
32507169	4	16	theme	membrane	939:946	arg1	wettability					948:958	membrane wettability	939:958	membrane wettability	939:958	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	17	theme	mechanical	914:923	arg1	property					925:932	mechanical property	914:932	mechanical property	914:932	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	1	18	theme	oily	283:286	arg1	wastewater					288:297	oily wastewater	283:297	oily wastewater	283:297	Recently, the growing environmental concerns and economic demands drive the need to develop effective solutions for the treatment of oily wastewater, especially for oil/water emulsions.
32507169	2	19	theme	water-in-oil	556:567	arg1	emulsions					569:577	water-in-oil emulsions	556:577	water-in-oil emulsions	556:577	In this work, hydroxyethyl cellulose (HEC) and poly(acrylic acid) (PAA) are selected to form a complex membrane on the surface of poly(ethylene terephthalate) (PET) nonwoven via layer-by-layer assembly for separation of water-in-oil emulsions.
32507169	1	20	theme	wastewater	288:297	arg1	treatment					270:278	the treatment	266:278	the treatment of oily wastewater	266:297	Recently, the growing environmental concerns and economic demands drive the need to develop effective solutions for the treatment of oily wastewater, especially for oil/water emulsions.
32507169	0	21	theme	chemical	130:137	arg1	treatment					139:147	Thermal versus chemical treatment	115:147	Thermal versus chemical treatment	115:147	The change from hydrophilicity to hydrophobicity of HEC/PAA complex membrane for water-in-oil emulsion separation: Thermal versus chemical treatment.
32507169	5	22	theme	excellent	1160:1168	arg1	efficiencies					1181:1192	excellent separation efficiencies	1160:1192	excellent separation efficiencies	1160:1192	When the membranes are applied as oil filters to treat water-in-oil emulsions with different concentrations, both of the modified membranes show excellent separation efficiencies with a more than 99.4% rejection for all tested water-in-oil emulsions.
32507169	5	23	dep	%	1215:1215	arg1	99.4					1211:1214	99.4	1211:1214	99.4	1211:1214	When the membranes are applied as oil filters to treat water-in-oil emulsions with different concentrations, both of the modified membranes show excellent separation efficiencies with a more than 99.4% rejection for all tested water-in-oil emulsions.
32507169	2	24	theme	complex	431:437	arg1	membrane					439:446	a complex membrane	429:446	a complex membrane	429:446	In this work, hydroxyethyl cellulose (HEC) and poly(acrylic acid) (PAA) are selected to form a complex membrane on the surface of poly(ethylene terephthalate) (PET) nonwoven via layer-by-layer assembly for separation of water-in-oil emulsions.
32507169	5	25	theme	separation	1170:1179	arg1	efficiencies					1181:1192	excellent separation efficiencies	1160:1192	excellent separation efficiencies	1160:1192	When the membranes are applied as oil filters to treat water-in-oil emulsions with different concentrations, both of the modified membranes show excellent separation efficiencies with a more than 99.4% rejection for all tested water-in-oil emulsions.
32507169	5	26	dep	rejection	1217:1225	arg1	%					1215:1215	%	1215:1215	%	1215:1215	When the membranes are applied as oil filters to treat water-in-oil emulsions with different concentrations, both of the modified membranes show excellent separation efficiencies with a more than 99.4% rejection for all tested water-in-oil emulsions.
32507169	3	27	theme	hydrogen-bonded	724:738	arg1	membrane					756:763	the hydrogen-bonded HEC/PAA complex membrane	720:763	the hydrogen-bonded HEC/PAA complex membrane	720:763	In order to obtain a hydrophobic surface, two post-treatment methods, thermally and chemically induced cross-linking, are applied to modify the hydrogen-bonded HEC/PAA complex membrane.
32507169	4	28	theme	thermal	895:901	arg1	stability					903:911	thermal stability	895:911	thermal stability	895:911	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	5	29	theme	oil	1049:1051	arg1	membranes					1024:1032	the membranes	1020:1032	the membranes	1020:1032	When the membranes are applied as oil filters to treat water-in-oil emulsions with different concentrations, both of the modified membranes show excellent separation efficiencies with a more than 99.4% rejection for all tested water-in-oil emulsions.
32507169	5	29	theme	oil	1049:1051	arg1	filters					1053:1059	oil filters	1049:1059	oil filters	1049:1059	When the membranes are applied as oil filters to treat water-in-oil emulsions with different concentrations, both of the modified membranes show excellent separation efficiencies with a more than 99.4% rejection for all tested water-in-oil emulsions.
32507169	3	30	theme	complex	748:754	arg1	membrane					756:763	the hydrogen-bonded HEC/PAA complex membrane	720:763	the hydrogen-bonded HEC/PAA complex membrane	720:763	In order to obtain a hydrophobic surface, two post-treatment methods, thermally and chemically induced cross-linking, are applied to modify the hydrogen-bonded HEC/PAA complex membrane.
32507169	2	31	theme	acrylic	388:394	arg1	poly					383:386	poly	383:386	poly(acrylic acid) (PAA)	383:406	In this work, hydroxyethyl cellulose (HEC) and poly(acrylic acid) (PAA) are selected to form a complex membrane on the surface of poly(ethylene terephthalate) (PET) nonwoven via layer-by-layer assembly for separation of water-in-oil emulsions.
32507169	2	31	theme	acrylic	388:394	arg1	acid					396:399	acrylic acid	388:399	acrylic acid	388:399	In this work, hydroxyethyl cellulose (HEC) and poly(acrylic acid) (PAA) are selected to form a complex membrane on the surface of poly(ethylene terephthalate) (PET) nonwoven via layer-by-layer assembly for separation of water-in-oil emulsions.
32507169	0	32	theme	HEC/PAA	52:58	arg1	membrane					68:75	HEC/PAA complex membrane	52:75	HEC/PAA complex membrane	52:75	The change from hydrophilicity to hydrophobicity of HEC/PAA complex membrane for water-in-oil emulsion separation: Thermal versus chemical treatment.
32507169	1	33	theme	oil/water	315:323	arg1	emulsions					325:333	oil/water emulsions	315:333	oil/water emulsions	315:333	Recently, the growing environmental concerns and economic demands drive the need to develop effective solutions for the treatment of oily wastewater, especially for oil/water emulsions.
32507169	2	34	theme	layer-by-layer	514:527	arg1	assembly					529:536	layer-by-layer assembly	514:536	layer-by-layer assembly	514:536	In this work, hydroxyethyl cellulose (HEC) and poly(acrylic acid) (PAA) are selected to form a complex membrane on the surface of poly(ethylene terephthalate) (PET) nonwoven via layer-by-layer assembly for separation of water-in-oil emulsions.
32507169	1	35	dep	environmental	172:184	arg1	concerns					186:193	concerns	186:193	concerns	186:193	Recently, the growing environmental concerns and economic demands drive the need to develop effective solutions for the treatment of oily wastewater, especially for oil/water emulsions.
32507169	1	35	dep	environmental	172:184	arg1	demands					208:214	demands	208:214	demands	208:214	Recently, the growing environmental concerns and economic demands drive the need to develop effective solutions for the treatment of oily wastewater, especially for oil/water emulsions.
32507169	4	36	theme	membranes	812:820	arg1	properties					770:779	The properties	766:779	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability	766:958	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	4	37	theme	chemical	853:860	arg1	structure					862:870	chemical structure	853:870	chemical structure	853:870	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	5	38	theme	modified	1136:1143	arg1	membranes					1145:1153	the modified membranes	1132:1153	the modified membranes	1132:1153	When the membranes are applied as oil filters to treat water-in-oil emulsions with different concentrations, both of the modified membranes show excellent separation efficiencies with a more than 99.4% rejection for all tested water-in-oil emulsions.
32507169	4	39	theme	chemical	873:880	arg1	composition					882:892	chemical composition	873:892	chemical composition	873:892	The properties of the two treated HEC/PAA-PET membranes, including surface morphology, chemical structure, chemical composition, thermal stability, mechanical property, and membrane wettability are systematically studied and compared to each other.
32507169	3	40	theme	hydrophobic	601:611	arg1	surface					613:619	a hydrophobic surface	599:619	a hydrophobic surface	599:619	In order to obtain a hydrophobic surface, two post-treatment methods, thermally and chemically induced cross-linking, are applied to modify the hydrogen-bonded HEC/PAA complex membrane.
32507169	0	41	theme	membrane	68:75	arg1	hydrophobicity					34:47	hydrophobicity	34:47	hydrophobicity of HEC/PAA complex membrane for water-in-oil emulsion separation	34:112	The change from hydrophilicity to hydrophobicity of HEC/PAA complex membrane for water-in-oil emulsion separation: Thermal versus chemical treatment.
32507169	1	42	theme	effective	242:250	arg1	solutions					252:260	effective solutions	242:260	effective solutions for the treatment of oily wastewater, especially for oil/water emulsions	242:333	Recently, the growing environmental concerns and economic demands drive the need to develop effective solutions for the treatment of oily wastewater, especially for oil/water emulsions.
32507169	0	43	theme	complex	60:66	arg1	membrane					68:75	HEC/PAA complex membrane	52:75	HEC/PAA complex membrane	52:75	The change from hydrophilicity to hydrophobicity of HEC/PAA complex membrane for water-in-oil emulsion separation: Thermal versus chemical treatment.
32507169	0	44	from	hydrophilicity	16:29	arg1	change					4:9	The change	0:9	The change from hydrophilicity to hydrophobicity of HEC/PAA complex membrane for water-in-oil emulsion separation	0:112	The change from hydrophilicity to hydrophobicity of HEC/PAA complex membrane for water-in-oil emulsion separation: Thermal versus chemical treatment.
32507169	0	45	dep	treatment	139:147	arg1	change					4:9	The change	0:9	The change from hydrophilicity to hydrophobicity of HEC/PAA complex membrane for water-in-oil emulsion separation	0:112	The change from hydrophilicity to hydrophobicity of HEC/PAA complex membrane for water-in-oil emulsion separation: Thermal versus chemical treatment.
32507169	3	46	theme	HEC/PAA	740:746	arg1	membrane					756:763	the hydrogen-bonded HEC/PAA complex membrane	720:763	the hydrogen-bonded HEC/PAA complex membrane	720:763	In order to obtain a hydrophobic surface, two post-treatment methods, thermally and chemically induced cross-linking, are applied to modify the hydrogen-bonded HEC/PAA complex membrane.
32429482	5	0	dep	=	1282:1282	arg1	M					1288:1288	1.0 M	1284:1288	1.0 M	1284:1288	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	4	1	theme	PEL	1117:1119	arg1	solution					1121:1128	the bulk oppositely charged PEL solution	1089:1128	the bulk oppositely charged PEL solution	1089:1128	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	1	2	from	substrates	259:268	arg1	z					327:327	deposition step z	311:327	deposition step z	311:327	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	2	from	substrates	259:268	arg1	cS					303:304	cS	303:304	cS	303:304	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	2	from	substrates	259:268	arg1	concentration					288:300	salt concentration	283:300	salt concentration (cS)	283:305	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	3	theme	/cellulose	211:220	arg1	PLL/CS					231:236	PLL/CS	231:236	PLL/CS	231:236	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	3	theme	/cellulose	211:220	arg1	sulfate					222:228	poly(l-lysine)/cellulose sulfate	197:228	poly(l-lysine)/cellulose sulfate (PLL/CS)	197:237	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	4	4	theme	PEM	915:917	arg1	deposition					919:928	the consecutive PEM deposition	899:928	the consecutive PEM deposition	899:928	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	5	5	theme	highest	1302:1308	arg1	mobility					1310:1317	the highest mobility	1298:1317	the highest mobility of PEL under high salt conditions	1298:1351	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	3	6	theme	1.0	598:600	arg1	M					593:593	M	593:593	M	593:593	By varying cS from 0 M to 1.0 M, a maximum of deposited amount was obtained at 0.1 M, so that both no salinity (0 M) and high salinity (1.0 M) revealed deposited amounts that were far lower than for mean salinity (0.1 M).
32429482	3	7	theme	deposited	618:626	arg1	amount					628:633	deposited amount	618:633	deposited amount	618:633	By varying cS from 0 M to 1.0 M, a maximum of deposited amount was obtained at 0.1 M, so that both no salinity (0 M) and high salinity (1.0 M) revealed deposited amounts that were far lower than for mean salinity (0.1 M).
32429482	5	8	theme	PEL	1177:1179	arg1	solutions					1181:1189	the PEL solutions	1173:1189	the PEL solutions	1173:1189	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	4	9	theme	composition	880:890	arg1	modulation					858:867	the detailed modulation	845:867	the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution	845:1128	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	1	10	theme	deposition	311:320	arg1	z					327:327	deposition step z	311:327	deposition step z	311:327	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	6	11	with	coatings	1399:1406	arg1	morphologies					1437:1448	morphologies	1437:1448	morphologies	1437:1448	These studies help to prepare functional PEM coatings with defined thicknesses and morphologies for the passivation and activation of material surfaces in the biomedical and food field.
32429482	6	11	with	coatings	1399:1406	arg1	thicknesses					1421:1431	defined thicknesses	1413:1431	defined thicknesses	1413:1431	These studies help to prepare functional PEM coatings with defined thicknesses and morphologies for the passivation and activation of material surfaces in the biomedical and food field.
32429482	5	12	theme	salt	1337:1340	arg1	conditions					1342:1351	high salt conditions	1332:1351	high salt conditions	1332:1351	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	2	13	theme	deposition	493:502	arg1	profiles					504:511	alternate PLL/CS deposition profiles	476:511	alternate PLL/CS deposition profiles (adsorbed amount versus z)	476:538	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	4	14	theme	charged	1109:1115	arg1	solution					1121:1128	the bulk oppositely charged PEL solution	1089:1128	the bulk oppositely charged PEL solution	1089:1128	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	1	15	theme	constant	332:339	arg1	cPEL					359:362	constant PEL concentration cPEL	332:362	constant PEL concentration cPEL = 0.01 M and pH = 7.0	332:384	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	2	16	theme	alternate	476:484	arg1	profiles					504:511	alternate PLL/CS deposition profiles	476:511	alternate PLL/CS deposition profiles (adsorbed amount versus z)	476:538	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	6	17	theme	PEM	1395:1397	arg1	coatings					1399:1406	functional PEM coatings	1384:1406	functional PEM coatings with defined thicknesses and morphologies	1384:1448	These studies help to prepare functional PEM coatings with defined thicknesses and morphologies for the passivation and activation of material surfaces in the biomedical and food field.
32429482	1	18	theme	concentration	345:357	arg1	cPEL					359:362	constant PEL concentration cPEL	332:362	constant PEL concentration cPEL = 0.01 M and pH = 7.0	332:384	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	6	19	from	activation	1474:1483	arg1	field					1533:1537	the biomedical and food field	1509:1537	the biomedical and food field	1509:1537	These studies help to prepare functional PEM coatings with defined thicknesses and morphologies for the passivation and activation of material surfaces in the biomedical and food field.
32429482	1	20	from	cPEL	359:362	arg1	z					327:327	deposition step z	311:327	deposition step z	311:327	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	20	from	cPEL	359:362	arg1	cS					303:304	cS	303:304	cS	303:304	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	20	from	cPEL	359:362	arg1	concentration					288:300	salt concentration	283:300	salt concentration (cS)	283:305	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	4	21	with	contact	1076:1082	arg1	solution					1121:1128	the bulk oppositely charged PEL solution	1089:1128	the bulk oppositely charged PEL solution	1089:1128	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	1	22	theme	salt	283:286	arg1	cS					303:304	cS	303:304	cS	303:304	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	22	theme	salt	283:286	arg1	concentration					288:300	salt concentration	283:300	salt concentration (cS)	283:305	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	3	23	theme	high	693:696	arg1	salinity					698:705	high salinity	693:705	high salinity (1.0 M)	693:713	By varying cS from 0 M to 1.0 M, a maximum of deposited amount was obtained at 0.1 M, so that both no salinity (0 M) and high salinity (1.0 M) revealed deposited amounts that were far lower than for mean salinity (0.1 M).
32429482	3	23	theme	high	693:696	arg1	M					712:712	1.0 M	708:712	1.0 M	708:712	By varying cS from 0 M to 1.0 M, a maximum of deposited amount was obtained at 0.1 M, so that both no salinity (0 M) and high salinity (1.0 M) revealed deposited amounts that were far lower than for mean salinity (0.1 M).
32429482	2	24	theme	PEM	560:562	arg1	amount					564:569	total deposited PEM amount	544:569	total deposited PEM amount	544:569	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	0	25	theme	/Cellulose	73:82	arg1	Multilayers					92:102	Poly(l-Lysine)/Cellulose Sulfate Multilayers	59:102	Poly(l-Lysine)/Cellulose Sulfate Multilayers	59:102	Anomalous Influence of Salt Concentration on Deposition of Poly(l-Lysine)/Cellulose Sulfate Multilayers Evidenced by In Situ ATR-FTIR.
32429482	4	26	from	interior	1010:1017	arg1	PEL					993:995	given PEL	987:995	given PEL from the PEM interior towards the outermost region	987:1046	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	4	26	from	interior	1010:1017	arg1	release					1052:1058	release	1052:1058	release of the PEM upon contact with the bulk oppositely charged PEL solution	1052:1128	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	4	26	from	interior	1010:1017	arg1	diffusion					974:982	both diffusion	969:982	both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution	969:1128	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	6	27	from	passivation	1458:1468	arg1	field					1533:1537	the biomedical and food field	1509:1537	the biomedical and food field	1509:1537	These studies help to prepare functional PEM coatings with defined thicknesses and morphologies for the passivation and activation of material surfaces in the biomedical and food field.
32429482	2	28	theme	total	544:548	arg1	amount					564:569	total deposited PEM amount	544:569	total deposited PEM amount	544:569	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	0	29	theme	Multilayers	92:102	arg1	Deposition					45:54	Deposition	45:54	Deposition of Poly(l-Lysine)/Cellulose Sulfate Multilayers	45:102	Anomalous Influence of Salt Concentration on Deposition of Poly(l-Lysine)/Cellulose Sulfate Multilayers Evidenced by In Situ ATR-FTIR.
32429482	5	30	dep	ex	1140:1141	arg1	situ					1143:1146	situ	1143:1146	situ	1143:1146	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	5	31	theme	distinct	1231:1238	arg1	release					1240:1246	the distinct release	1227:1246	the distinct release of PEL from the PEM	1227:1266	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	0	32	theme	Anomalous	0:8	arg1	Influence					10:18	Anomalous Influence	0:18	Anomalous Influence of Salt Concentration on Deposition of Poly(l-Lysine)/Cellulose Sulfate Multilayers	0:102	Anomalous Influence of Salt Concentration on Deposition of Poly(l-Lysine)/Cellulose Sulfate Multilayers Evidenced by In Situ ATR-FTIR.
32429482	5	33	theme	=	1282:1282	arg1	cS					1279:1280	cS	1279:1280	cS = 1.0 M	1279:1288	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	4	34	theme	PEL	993:995	arg1	diffusion					974:982	both diffusion	969:982	both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution	969:1128	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	3	35	dep	M	593:593	arg1	to					595:596	to	595:596	to	595:596	By varying cS from 0 M to 1.0 M, a maximum of deposited amount was obtained at 0.1 M, so that both no salinity (0 M) and high salinity (1.0 M) revealed deposited amounts that were far lower than for mean salinity (0.1 M).
32429482	5	36	from	measurements	1157:1168	arg1	solutions					1181:1189	the PEL solutions	1173:1189	the PEL solutions	1173:1189	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	4	37	theme	release	1052:1058	arg1	diffusion					974:982	both diffusion	969:982	both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution	969:1128	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	0	38	theme	Concentration	28:40	arg1	Influence					10:18	Anomalous Influence	0:18	Anomalous Influence of Salt Concentration on Deposition of Poly(l-Lysine)/Cellulose Sulfate Multilayers	0:102	Anomalous Influence of Salt Concentration on Deposition of Poly(l-Lysine)/Cellulose Sulfate Multilayers Evidenced by In Situ ATR-FTIR.
32429482	6	39	dep	passivation	1458:1468	arg1	the					1454:1456	the	1454:1456	the	1454:1456	These studies help to prepare functional PEM coatings with defined thicknesses and morphologies for the passivation and activation of material surfaces in the biomedical and food field.
32429482	2	40	used	used	433:436	arg2	spectroscopy					416:427	In situ ATR-FTIR spectroscopy	399:427	In situ ATR-FTIR spectroscopy	399:427	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	6	41	theme	surfaces	1497:1504	arg1	activation					1474:1483	activation	1474:1483	activation	1474:1483	These studies help to prepare functional PEM coatings with defined thicknesses and morphologies for the passivation and activation of material surfaces in the biomedical and food field.
32429482	6	41	theme	surfaces	1497:1504	arg1	passivation					1458:1468	passivation	1458:1468	passivation	1458:1468	These studies help to prepare functional PEM coatings with defined thicknesses and morphologies for the passivation and activation of material surfaces in the biomedical and food field.
32429482	2	42	dep	In	399:400	arg1	situ					402:405	situ	402:405	situ	402:405	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	4	43	theme	PEL	876:878	arg1	composition					880:890	the PEL composition	872:890	the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution	872:1128	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	5	44	theme	PEL	1322:1324	arg1	mobility					1310:1317	the highest mobility	1298:1317	the highest mobility of PEL under high salt conditions	1298:1351	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	4	45	theme	bulk	1093:1096	arg1	solution					1121:1128	the bulk oppositely charged PEL solution	1089:1128	the bulk oppositely charged PEL solution	1089:1128	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	2	46	theme	adsorbed	514:521	arg1	amount					523:528	adsorbed amount	514:528	adsorbed amount	514:528	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	4	47	theme	detailed	849:856	arg1	modulation					858:867	the detailed modulation	845:867	the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution	845:1128	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	3	48	theme	0	591:591	arg1	M					593:593	M	593:593	M	593:593	By varying cS from 0 M to 1.0 M, a maximum of deposited amount was obtained at 0.1 M, so that both no salinity (0 M) and high salinity (1.0 M) revealed deposited amounts that were far lower than for mean salinity (0.1 M).
32429482	1	49	theme	sulfate	222:228	arg1	PEMs					188:191	PEMs	188:191	PEMs	188:191	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	49	theme	sulfate	222:228	arg1	multilayers					175:185	polyelectrolyte (PEL) multilayers	153:185	polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS)	153:237	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	2	50	theme	profiles	504:511	arg1	determination					459:471	the quantitative determination	442:471	the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount	442:569	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	5	51	theme	PEM-20	1211:1216	arg1	deposition					1197:1206	deposition	1197:1206	deposition of PEM-20	1197:1216	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	1	52	theme	polyelectrolyte	153:167	arg1	PEMs					188:191	PEMs	188:191	PEMs	188:191	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	52	theme	polyelectrolyte	153:167	arg1	multilayers					175:185	polyelectrolyte (PEL) multilayers	153:185	polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS)	153:237	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	53	theme	PEL	170:172	arg1	PEMs					188:191	PEMs	188:191	PEMs	188:191	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	53	theme	PEL	170:172	arg1	multilayers					175:185	polyelectrolyte (PEL) multilayers	153:185	polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS)	153:237	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	3	54	theme	amount	628:633	arg1	maximum					607:613	a maximum	605:613	a maximum of deposited amount	605:633	By varying cS from 0 M to 1.0 M, a maximum of deposited amount was obtained at 0.1 M, so that both no salinity (0 M) and high salinity (1.0 M) revealed deposited amounts that were far lower than for mean salinity (0.1 M).
32429482	4	55	theme	PEM	1006:1008	arg1	interior					1010:1017	the PEM interior	1002:1017	the PEM interior	1002:1017	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	1	56	theme	multilayers	175:185	arg1	deposition					139:148	The deposition	135:148	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0	135:384	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	2	57	theme	quantitative	446:457	arg1	determination					459:471	the quantitative determination	442:471	the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount	442:569	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	4	58	theme	consecutive	903:913	arg1	deposition					919:928	the consecutive PEM deposition	899:928	the consecutive PEM deposition	899:928	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	5	59	theme	high	1332:1335	arg1	conditions					1342:1351	high salt conditions	1332:1351	high salt conditions	1332:1351	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	1	60	theme	step	322:325	arg1	z					327:327	deposition step z	311:327	deposition step z	311:327	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	2	61	dep	profiles	504:511	arg1	z					537:537	z	537:537	z	537:537	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	2	61	dep	profiles	504:511	arg1	amount					523:528	adsorbed amount	514:528	adsorbed amount	514:528	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	6	62	theme	defined	1413:1419	arg1	thicknesses					1421:1431	defined thicknesses	1413:1431	defined thicknesses	1413:1431	These studies help to prepare functional PEM coatings with defined thicknesses and morphologies for the passivation and activation of material surfaces in the biomedical and food field.
32429482	2	63	theme	PLL/CS	486:491	arg1	profiles					504:511	alternate PLL/CS deposition profiles	476:511	alternate PLL/CS deposition profiles (adsorbed amount versus z)	476:538	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	1	64	theme	PEL	341:343	arg1	cPEL					359:362	constant PEL concentration cPEL	332:362	constant PEL concentration cPEL = 0.01 M and pH = 7.0	332:384	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	6	65	theme	functional	1384:1393	arg1	coatings					1399:1406	functional PEM coatings	1384:1406	functional PEM coatings with defined thicknesses and morphologies	1384:1448	These studies help to prepare functional PEM coatings with defined thicknesses and morphologies for the passivation and activation of material surfaces in the biomedical and food field.
32429482	5	66	from	PEM	1264:1266	arg1	release					1240:1246	the distinct release	1227:1246	the distinct release of PEL from the PEM	1227:1266	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	2	67	theme	In	399:400	arg1	spectroscopy					416:427	In situ ATR-FTIR spectroscopy	399:427	In situ ATR-FTIR spectroscopy	399:427	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	6	68	theme	material	1488:1495	arg1	surfaces					1497:1504	material surfaces	1488:1504	material surfaces	1488:1504	These studies help to prepare functional PEM coatings with defined thicknesses and morphologies for the passivation and activation of material surfaces in the biomedical and food field.
32429482	0	69	from	Influence	10:18	arg1	Deposition					45:54	Deposition	45:54	Deposition of Poly(l-Lysine)/Cellulose Sulfate Multilayers	45:102	Anomalous Influence of Salt Concentration on Deposition of Poly(l-Lysine)/Cellulose Sulfate Multilayers Evidenced by In Situ ATR-FTIR.
32429482	5	70	theme	PEL	1251:1253	arg1	release					1240:1246	the distinct release	1227:1246	the distinct release of PEL from the PEM	1227:1266	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	2	71	theme	amount	564:569	arg1	determination					459:471	the quantitative determination	442:471	the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount	442:569	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	0	72	theme	Sulfate	84:90	arg1	Multilayers					92:102	Poly(l-Lysine)/Cellulose Sulfate Multilayers	59:102	Poly(l-Lysine)/Cellulose Sulfate Multilayers	59:102	Anomalous Influence of Salt Concentration on Deposition of Poly(l-Lysine)/Cellulose Sulfate Multilayers Evidenced by In Situ ATR-FTIR.
32429482	1	73	dep	=	380:380	arg1	M					371:371	M	371:371	M	371:371	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	2	74	theme	deposited	550:558	arg1	amount					564:569	total deposited PEM amount	544:569	total deposited PEM amount	544:569	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	3	75	theme	deposited	724:732	arg1	amounts					734:740	deposited amounts	724:740	deposited amounts that were far lower than for mean salinity (0.1 M)	724:791	By varying cS from 0 M to 1.0 M, a maximum of deposited amount was obtained at 0.1 M, so that both no salinity (0 M) and high salinity (1.0 M) revealed deposited amounts that were far lower than for mean salinity (0.1 M).
32429482	2	76	theme	ATR-FTIR	407:414	arg1	spectroscopy					416:427	In situ ATR-FTIR spectroscopy	399:427	In situ ATR-FTIR spectroscopy	399:427	In situ ATR-FTIR spectroscopy was used for the quantitative determination of alternate PLL/CS deposition profiles (adsorbed amount versus z) and total deposited PEM amount.
32429482	4	77	theme	given	987:991	arg1	PEL					993:995	given PEL	987:995	given PEL from the PEM interior towards the outermost region	987:1046	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	0	78	theme	Salt	23:26	arg1	Concentration					28:40	Salt Concentration	23:40	Salt Concentration	23:40	Anomalous Influence of Salt Concentration on Deposition of Poly(l-Lysine)/Cellulose Sulfate Multilayers Evidenced by In Situ ATR-FTIR.
32429482	6	79	theme	food	1528:1531	arg1	field					1533:1537	the biomedical and food field	1509:1537	the biomedical and food field	1509:1537	These studies help to prepare functional PEM coatings with defined thicknesses and morphologies for the passivation and activation of material surfaces in the biomedical and food field.
32429482	1	80	theme	germanium	244:252	arg1	substrates					259:268	germanium (Ge) substrates	244:268	germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0	244:384	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	4	81	from	diffusion	974:982	arg1	interior					1010:1017	the PEM interior	1002:1017	the PEM interior	1002:1017	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	6	82	theme	biomedical	1513:1522	arg1	field					1533:1537	the biomedical and food field	1509:1537	the biomedical and food field	1509:1537	These studies help to prepare functional PEM coatings with defined thicknesses and morphologies for the passivation and activation of material surfaces in the biomedical and food field.
32429482	4	83	theme	PEM	1067:1069	arg1	PEL					993:995	given PEL	987:995	given PEL from the PEM interior towards the outermost region	987:1046	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	4	83	theme	PEM	1067:1069	arg1	release					1052:1058	release	1052:1058	release of the PEM upon contact with the bulk oppositely charged PEL solution	1052:1128	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	5	84	theme	ex	1140:1141	arg1	measurements					1157:1168	ex situ ATR-FTIR measurements	1140:1168	ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20	1140:1216	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	3	85	theme	mean	771:774	arg1	salinity					776:783	mean salinity	771:783	mean salinity (0.1 M)	771:791	By varying cS from 0 M to 1.0 M, a maximum of deposited amount was obtained at 0.1 M, so that both no salinity (0 M) and high salinity (1.0 M) revealed deposited amounts that were far lower than for mean salinity (0.1 M).
32429482	3	85	theme	mean	771:774	arg1	M					790:790	0.1 M	786:790	0.1 M	786:790	By varying cS from 0 M to 1.0 M, a maximum of deposited amount was obtained at 0.1 M, so that both no salinity (0 M) and high salinity (1.0 M) revealed deposited amounts that were far lower than for mean salinity (0.1 M).
32429482	4	86	theme	outermost	1031:1039	arg1	region					1041:1046	the outermost region	1027:1046	the outermost region	1027:1046	Furthermore, in situ ATR-FTIR allowed to determine the detailed modulation of the PEL composition during the consecutive PEM deposition, which was interpreted as being due to both diffusion of given PEL from the PEM interior towards the outermost region and release of the PEM upon contact with the bulk oppositely charged PEL solution.
32429482	5	87	theme	ATR-FTIR	1148:1155	arg1	measurements					1157:1168	ex situ ATR-FTIR measurements	1140:1168	ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20	1140:1216	Finally, ex situ ATR-FTIR measurements on the PEL solutions after deposition of PEM-20 revealed the distinct release of PEL from the PEM solely for cS = 1.0 M, due to the highest mobility of PEL under high salt conditions.
32429482	1	88	theme	poly	197:200	arg1	PLL/CS					231:236	PLL/CS	231:236	PLL/CS	231:236	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	88	theme	poly	197:200	arg1	sulfate					222:228	poly(l-lysine)/cellulose sulfate	197:228	poly(l-lysine)/cellulose sulfate (PLL/CS)	197:237	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	89	theme	l-lysine	202:209	arg1	PLL/CS					231:236	PLL/CS	231:236	PLL/CS	231:236	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
32429482	1	89	theme	l-lysine	202:209	arg1	sulfate					222:228	poly(l-lysine)/cellulose sulfate	197:228	poly(l-lysine)/cellulose sulfate (PLL/CS)	197:237	The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied.
33712127	8	0	theme	n-HA/PA6	1183:1190	arg1	scaffolds					1202:1210	PA6/CS@n-HA/PA6 bilayered scaffolds	1176:1210	PA6/CS@n-HA/PA6 bilayered scaffolds	1176:1210	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	8	1	theme	PA6/CS	1176:1181	arg1	scaffolds					1202:1210	PA6/CS@n-HA/PA6 bilayered scaffolds	1176:1210	PA6/CS@n-HA/PA6 bilayered scaffolds	1176:1210	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	7	2	theme	PA6/CS	1047:1052	arg1	composites					1063:1072	PA6/CS@n-HA/PA6 composites	1047:1072	PA6/CS@n-HA/PA6 composites	1047:1072	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	3	3	theme	electrospinning	567:581	arg1	technique					583:591	an electrospinning technique	564:591	an electrospinning technique	564:591	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	0	4	theme	bone	128:131	arg1	regeneration					133:144	guided bone regeneration	121:144	guided bone regeneration	121:144	Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration.
33712127	5	5	theme	electrospun	724:734	arg1	layers					743:748	electrospun PA6/CS layers	724:748	electrospun PA6/CS layers	724:748	The results show that n-HA/PA6 and electrospun PA6/CS layers are tightly bound by molecular interaction and chemical bonding, which enhances the bonding strength between two distinct layers.
33712127	7	6	theme	elastic	1028:1034	arg1	MPa					1090:1092	1.41 ± 0.18 MPa	1078:1092	1.41 ± 0.18 MPa	1078:1092	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	7	6	theme	elastic	1028:1034	arg1	strength					1015:1022	tensile strength	1007:1022	tensile strength	1007:1022	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	7	6	theme	elastic	1028:1034	arg1	modulus					1036:1042	elastic modulus	1028:1042	elastic modulus	1028:1042	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	5	7	theme	PA6/CS	736:741	arg1	layers					743:748	electrospun PA6/CS layers	724:748	electrospun PA6/CS layers	724:748	The results show that n-HA/PA6 and electrospun PA6/CS layers are tightly bound by molecular interaction and chemical bonding, which enhances the bonding strength between two distinct layers.
33712127	6	8	theme	@	943:943	arg1	membranes					953:961	the PA6/CS@n-HA/PA6 membranes	933:961	the PA6/CS@n-HA/PA6 membranes	933:961	The porosity and adsorption average pore diameter of the PA6/CS@n-HA/PA6 membranes are 36.90 % and 22.61 nm, respectively.
33712127	8	9	contain	have	1212:1215	arg2	osteoconductivity					1275:1291	osteoconductivity	1275:1291	osteoconductivity	1275:1291	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	8	9	contain	have	1212:1215	arg1	scaffolds					1202:1210	PA6/CS@n-HA/PA6 bilayered scaffolds	1176:1210	PA6/CS@n-HA/PA6 bilayered scaffolds	1176:1210	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	8	9	contain	have	1212:1215	arg2	biocompatibility					1254:1269	biocompatibility	1254:1269	biocompatibility	1254:1269	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	8	9	contain	have	1212:1215	arg2	bioactivity					1241:1251	good bioactivity	1236:1251	good bioactivity	1236:1251	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	8	9	contain	have	1212:1215	arg2	safety					1228:1233	biological safety	1217:1233	biological safety	1217:1233	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	8	10	theme	bilayered	1192:1200	arg1	scaffolds					1202:1210	PA6/CS@n-HA/PA6 bilayered scaffolds	1176:1210	PA6/CS@n-HA/PA6 bilayered scaffolds	1176:1210	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	2	11	theme	Bone	219:222	arg1	methods					296:302	the most successful methods	276:302	the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration	276:398	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	2	11	theme	Bone	219:222	arg1	one					269:271	one	269:271	one	269:271	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	2	11	theme	Bone	219:222	arg1	membrane					243:250	Guided Bone Regeneration (GBR) membrane	212:250	Guided Bone Regeneration (GBR) membrane	212:250	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	8	12	theme	biological	1217:1226	arg1	safety					1228:1233	biological safety	1217:1233	biological safety	1217:1233	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	2	13	theme	Guided	212:217	arg1	methods					296:302	the most successful methods	276:302	the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration	276:398	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	2	13	theme	Guided	212:217	arg1	one					269:271	one	269:271	one	269:271	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	2	13	theme	Guided	212:217	arg1	membrane					243:250	Guided Bone Regeneration (GBR) membrane	212:250	Guided Bone Regeneration (GBR) membrane	212:250	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	2	14	theme	alveolar	327:334	arg1	bone					336:339	alveolar bone	327:339	alveolar bone	327:339	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	8	15	theme	good	1236:1239	arg1	bioactivity					1241:1251	good bioactivity	1236:1251	good bioactivity	1236:1251	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	0	16	theme	bilayered	97:105	arg1	membranes					107:115	nano-hydroxyapatite/polyamide-6 composite bilayered membranes	55:115	nano-hydroxyapatite/polyamide-6 composite bilayered membranes	55:115	Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration.
33712127	3	17	theme	@	484:484	arg1	nano-hydroxyapatite/polyamide-6					445:475	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6	416:475	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue	416:510	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	3	17	theme	@	484:484	arg1	n-HA/PA6					485:492	PA6/CS@n-HA/PA6	478:492	PA6/CS@n-HA/PA6	478:492	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	1	18	from	challenge	186:194	arg1	orthopedics					199:209	orthopedics	199:209	orthopedics	199:209	Periodontal defect poses a significant challenge in orthopedics.
33712127	0	19	theme	Electrospun	0:10	arg1	nanofibers					33:42	Electrospun polyamide-6/chitosan nanofibers	0:42	Electrospun polyamide-6/chitosan nanofibers	0:42	Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration.
33712127	0	20	theme	polyamide-6/chitosan	12:31	arg1	nanofibers					33:42	Electrospun polyamide-6/chitosan nanofibers	0:42	Electrospun polyamide-6/chitosan nanofibers	0:42	Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration.
33712127	6	21	theme	membranes	953:961	arg1	porosity					884:891	porosity	884:891	porosity	884:891	The porosity and adsorption average pore diameter of the PA6/CS@n-HA/PA6 membranes are 36.90 % and 22.61 nm, respectively.
33712127	6	21	theme	membranes	953:961	arg1	%					973:973	36.90 %	967:973	36.90 %	967:973	The porosity and adsorption average pore diameter of the PA6/CS@n-HA/PA6 membranes are 36.90 % and 22.61 nm, respectively.
33712127	6	21	theme	membranes	953:961	arg1	adsorption					897:906	adsorption	897:906	adsorption	897:906	The porosity and adsorption average pore diameter of the PA6/CS@n-HA/PA6 membranes are 36.90 % and 22.61 nm, respectively.
33712127	7	22	theme	tensile	1007:1013	arg1	MPa					1090:1092	1.41 ± 0.18 MPa	1078:1092	1.41 ± 0.18 MPa	1078:1092	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	7	22	theme	tensile	1007:1013	arg1	strength					1015:1022	tensile strength	1007:1022	tensile strength	1007:1022	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	7	22	theme	tensile	1007:1013	arg1	modulus					1036:1042	elastic modulus	1028:1042	elastic modulus	1028:1042	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	2	23	theme	periodontal	361:371	arg1	repair/regeneration					380:398	periodontal defect repair/regeneration	361:398	periodontal defect repair/regeneration	361:398	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	8	24	theme	cell	1138:1141	arg1	studies					1151:1157	In vitro cell culture studies	1129:1157	In vitro cell culture studies	1129:1157	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	3	25	theme	nano-hydroxyapatite/polyamide-6	445:475	arg1	tissue					505:510	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue	416:510	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue	416:510	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	4	26	theme	n-HA/PA6	628:635	arg1	composites					637:646	The developed PA6/CS@n-HA/PA6 composites	607:646	The developed PA6/CS@n-HA/PA6 composites	607:646	The developed PA6/CS@n-HA/PA6 composites were characterized by a series of tests.
33712127	1	27	theme	Periodontal	147:157	arg1	defect					159:164	Periodontal defect	147:164	Periodontal defect	147:164	Periodontal defect poses a significant challenge in orthopedics.
33712127	6	28	dep	porosity	884:891	arg1	diameter					921:928	average pore diameter	908:928	average pore diameter	908:928	The porosity and adsorption average pore diameter of the PA6/CS@n-HA/PA6 membranes are 36.90 % and 22.61 nm, respectively.
33712127	6	28	dep	porosity	884:891	arg1	The					880:882	The	880:882	The	880:882	The porosity and adsorption average pore diameter of the PA6/CS@n-HA/PA6 membranes are 36.90 % and 22.61 nm, respectively.
33712127	3	29	theme	bilayered	495:503	arg1	tissue					505:510	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue	416:510	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue	416:510	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	3	30	theme	novel	418:422	arg1	nano-hydroxyapatite/polyamide-6					445:475	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6	416:475	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue	416:510	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	3	30	theme	novel	418:422	arg1	n-HA/PA6					485:492	PA6/CS@n-HA/PA6	478:492	PA6/CS@n-HA/PA6	478:492	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	4	31	theme	@	627:627	arg1	composites					637:646	The developed PA6/CS@n-HA/PA6 composites	607:646	The developed PA6/CS@n-HA/PA6 composites	607:646	The developed PA6/CS@n-HA/PA6 composites were characterized by a series of tests.
33712127	5	32	theme	molecular	771:779	arg1	interaction					781:791	molecular interaction	771:791	molecular interaction	771:791	The results show that n-HA/PA6 and electrospun PA6/CS layers are tightly bound by molecular interaction and chemical bonding, which enhances the bonding strength between two distinct layers.
33712127	8	33	dep	In	1129:1130	arg1	vitro					1132:1136	vitro	1132:1136	vitro	1132:1136	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	3	34	theme	polyamide-6/chitosan	424:443	arg1	nano-hydroxyapatite/polyamide-6					445:475	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6	416:475	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue	416:510	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	3	34	theme	polyamide-6/chitosan	424:443	arg1	n-HA/PA6					485:492	PA6/CS@n-HA/PA6	478:492	PA6/CS@n-HA/PA6	478:492	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	6	35	theme	n-HA/PA6	944:951	arg1	membranes					953:961	the PA6/CS@n-HA/PA6 membranes	933:961	the PA6/CS@n-HA/PA6 membranes	933:961	The porosity and adsorption average pore diameter of the PA6/CS@n-HA/PA6 membranes are 36.90 % and 22.61 nm, respectively.
33712127	8	36	theme	@	1182:1182	arg1	scaffolds					1202:1210	PA6/CS@n-HA/PA6 bilayered scaffolds	1176:1210	PA6/CS@n-HA/PA6 bilayered scaffolds	1176:1210	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	0	37	theme	composite	87:95	arg1	membranes					107:115	nano-hydroxyapatite/polyamide-6 composite bilayered membranes	55:115	nano-hydroxyapatite/polyamide-6 composite bilayered membranes	55:115	Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration.
33712127	7	38	theme	±	1103:1103	arg1	MPa					1110:1112	7.15 ± 1.09 MPa	1098:1112	7.15 ± 1.09 MPa	1098:1112	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	2	39	theme	GBR	238:240	arg1	methods					296:302	the most successful methods	276:302	the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration	276:398	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	2	39	theme	GBR	238:240	arg1	one					269:271	one	269:271	one	269:271	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	2	39	theme	GBR	238:240	arg1	membrane					243:250	Guided Bone Regeneration (GBR) membrane	212:250	Guided Bone Regeneration (GBR) membrane	212:250	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	5	40	theme	distinct	863:870	arg1	layers					872:877	two distinct layers	859:877	two distinct layers	859:877	The results show that n-HA/PA6 and electrospun PA6/CS layers are tightly bound by molecular interaction and chemical bonding, which enhances the bonding strength between two distinct layers.
33712127	5	41	theme	chemical	797:804	arg1	bonding					806:812	chemical bonding	797:812	chemical bonding	797:812	The results show that n-HA/PA6 and electrospun PA6/CS layers are tightly bound by molecular interaction and chemical bonding, which enhances the bonding strength between two distinct layers.
33712127	6	42	theme	PA6/CS	937:942	arg1	membranes					953:961	the PA6/CS@n-HA/PA6 membranes	933:961	the PA6/CS@n-HA/PA6 membranes	933:961	The porosity and adsorption average pore diameter of the PA6/CS@n-HA/PA6 membranes are 36.90 % and 22.61 nm, respectively.
33712127	8	43	theme	culture	1143:1149	arg1	studies					1151:1157	In vitro cell culture studies	1129:1157	In vitro cell culture studies	1129:1157	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33712127	2	44	theme	Regeneration	224:235	arg1	methods					296:302	the most successful methods	276:302	the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration	276:398	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	2	44	theme	Regeneration	224:235	arg1	one					269:271	one	269:271	one	269:271	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	2	44	theme	Regeneration	224:235	arg1	membrane					243:250	Guided Bone Regeneration (GBR) membrane	212:250	Guided Bone Regeneration (GBR) membrane	212:250	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	7	45	theme	±	1083:1083	arg1	MPa					1090:1092	1.41 ± 0.18 MPa	1078:1092	1.41 ± 0.18 MPa	1078:1092	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	7	45	theme	±	1083:1083	arg1	strength					1015:1022	tensile strength	1007:1022	tensile strength	1007:1022	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	7	45	theme	±	1083:1083	arg1	modulus					1036:1042	elastic modulus	1028:1042	elastic modulus	1028:1042	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	3	46	theme	PA6/CS	478:483	arg1	nano-hydroxyapatite/polyamide-6					445:475	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6	416:475	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue	416:510	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	3	46	theme	PA6/CS	478:483	arg1	n-HA/PA6					485:492	PA6/CS@n-HA/PA6	478:492	PA6/CS@n-HA/PA6	478:492	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	4	47	theme	PA6/CS	621:626	arg1	composites					637:646	The developed PA6/CS@n-HA/PA6 composites	607:646	The developed PA6/CS@n-HA/PA6 composites	607:646	The developed PA6/CS@n-HA/PA6 composites were characterized by a series of tests.
33712127	7	48	theme	7.15	1098:1101	arg1	MPa					1110:1112	7.15 ± 1.09 MPa	1098:1112	7.15 ± 1.09 MPa	1098:1112	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	7	49	theme	composites	1063:1072	arg1	MPa					1090:1092	1.41 ± 0.18 MPa	1078:1092	1.41 ± 0.18 MPa	1078:1092	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	7	49	theme	composites	1063:1072	arg1	strength					1015:1022	tensile strength	1007:1022	tensile strength	1007:1022	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	7	49	theme	composites	1063:1072	arg1	modulus					1036:1042	elastic modulus	1028:1042	elastic modulus	1028:1042	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	1	50	theme	significant	174:184	arg1	challenge					186:194	a significant challenge	172:194	a significant challenge in orthopedics	172:209	Periodontal defect poses a significant challenge in orthopedics.
33712127	7	51	dep	strength	1015:1022	arg1	The					1003:1005	The	1003:1005	The	1003:1005	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	4	52	theme	developed	611:619	arg1	composites					637:646	The developed PA6/CS@n-HA/PA6 composites	607:646	The developed PA6/CS@n-HA/PA6 composites	607:646	The developed PA6/CS@n-HA/PA6 composites were characterized by a series of tests.
33712127	3	53	theme	solvent	544:550	arg1	casting					552:558	a solvent casting	542:558	a solvent casting	542:558	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	4	54	theme	tests	682:686	arg1	series					672:677	a series	670:677	a series of tests	670:686	The developed PA6/CS@n-HA/PA6 composites were characterized by a series of tests.
33712127	6	55	theme	pore	916:919	arg1	diameter					921:928	average pore diameter	908:928	average pore diameter	908:928	The porosity and adsorption average pore diameter of the PA6/CS@n-HA/PA6 membranes are 36.90 % and 22.61 nm, respectively.
33712127	7	56	theme	@	1053:1053	arg1	composites					1063:1072	PA6/CS@n-HA/PA6 composites	1047:1072	PA6/CS@n-HA/PA6 composites	1047:1072	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	2	57	theme	defect	373:378	arg1	repair/regeneration					380:398	periodontal defect repair/regeneration	361:398	periodontal defect repair/regeneration	361:398	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	0	58	theme	guided	121:126	arg1	regeneration					133:144	guided bone regeneration	121:144	guided bone regeneration	121:144	Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration.
33712127	6	59	theme	average	908:914	arg1	diameter					921:928	average pore diameter	908:928	average pore diameter	908:928	The porosity and adsorption average pore diameter of the PA6/CS@n-HA/PA6 membranes are 36.90 % and 22.61 nm, respectively.
33712127	2	60	theme	methods	296:302	arg1	methods					296:302	the most successful methods	276:302	the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration	276:398	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	2	60	theme	methods	296:302	arg1	one					269:271	one	269:271	one	269:271	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	2	60	theme	methods	296:302	arg1	membrane					243:250	Guided Bone Regeneration (GBR) membrane	212:250	Guided Bone Regeneration (GBR) membrane	212:250	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	7	61	theme	n-HA/PA6	1054:1061	arg1	composites					1063:1072	PA6/CS@n-HA/PA6 composites	1047:1072	PA6/CS@n-HA/PA6 composites	1047:1072	The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively.
33712127	5	62	theme	bonding	834:840	arg1	strength					842:849	the bonding strength	830:849	the bonding strength between two distinct layers	830:877	The results show that n-HA/PA6 and electrospun PA6/CS layers are tightly bound by molecular interaction and chemical bonding, which enhances the bonding strength between two distinct layers.
33712127	2	63	theme	successful	285:294	arg1	methods					296:302	the most successful methods	276:302	the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration	276:398	Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration.
33712127	3	64	theme	@	444:444	arg1	nano-hydroxyapatite/polyamide-6					445:475	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6	416:475	a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue	416:510	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	3	64	theme	@	444:444	arg1	n-HA/PA6					485:492	PA6/CS@n-HA/PA6	478:492	PA6/CS@n-HA/PA6	478:492	In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed.
33712127	8	65	theme	In	1129:1130	arg1	studies					1151:1157	In vitro cell culture studies	1129:1157	In vitro cell culture studies	1129:1157	In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
33433684	7	0	theme	basolateral	1158:1168	arg1	domains					1179:1185	the basolateral membrane domains	1154:1185	the basolateral membrane domains	1154:1185	LPS disrupted the tight junction barrier and caused compositional changes in localization of claudin-3 and claudin-4, although tight junctions were maintained to separate the apical membrane domains and the basolateral membrane domains.
33433684	7	1	theme	claudin-3	1044:1052	arg1	localization					1028:1039	localization	1028:1039	localization of claudin-3 and claudin-4	1028:1066	LPS disrupted the tight junction barrier and caused compositional changes in localization of claudin-3 and claudin-4, although tight junctions were maintained to separate the apical membrane domains and the basolateral membrane domains.
33433684	8	2	from	localization	1258:1269	arg1	BMECs					1320:1324	lactating BMECs	1310:1324	lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling	1310:1378	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	2	3	theme	cell	243:246	arg1	component					253:261	cell wall component	243:261	cell wall component	243:261	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	5	4	theme	culture	770:776	arg1	model					778:782	an in vitro culture model	758:782	an in vitro culture model	758:782	In this study, we investigated the influence of LPS on membrane proteins using an in vitro culture model.
33433684	1	5	theme	dairy	173:177	arg1	cows					179:182	dairy cows	173:182	dairy cows	173:182	Mastitis causes a decrease in milk yield and abnormalities in milk components from dairy cows.
33433684	6	6	theme	lateral	869:875	arg1	membranes					877:885	lateral membranes	869:885	lateral membranes	869:885	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	7	7	theme	tight	969:973	arg1	barrier					984:990	the tight junction barrier	965:990	the tight junction barrier	965:990	LPS disrupted the tight junction barrier and caused compositional changes in localization of claudin-3 and claudin-4, although tight junctions were maintained to separate the apical membrane domains and the basolateral membrane domains.
33433684	0	8	theme	LPS	19:21	arg1	effects					8:14	Adverse effects	0:14	Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells	0:87	Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells.
33433684	5	9	theme	in	761:762	arg1	model					778:782	an in vitro culture model	758:782	an in vitro culture model	758:782	In this study, we investigated the influence of LPS on membrane proteins using an in vitro culture model.
33433684	6	10	theme	aquaporin-3	854:864	arg1	loss					820:823	a loss	818:823	a loss of glucose transporter-1 and aquaporin-3 at lateral membranes	818:885	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	6	10	theme	aquaporin-3	854:864	arg1	decrease					893:900	a decrease	891:900	a decrease in milk production in response to LPS treatment	891:948	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	4	11	theme	Various	424:430	arg1	sensors					466:472	immune sensors	459:472	immune sensors (Toll-like receptors, TLR)	459:499	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	11	theme	Various	424:430	arg1	proteins					441:448	Various membrane proteins	424:448	Various membrane proteins	424:448	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	12	theme	mastitis	641:648	arg1	onset					632:636	the onset	628:636	the onset of mastitis or milk production in BMECs	628:676	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	1	13	from	cows	179:182	arg1	abnormalities					135:147	abnormalities	135:147	abnormalities in milk components from dairy cows	135:182	Mastitis causes a decrease in milk yield and abnormalities in milk components from dairy cows.
33433684	1	13	from	cows	179:182	arg1	decrease					108:115	a decrease	106:115	a decrease in milk yield	106:129	Mastitis causes a decrease in milk yield and abnormalities in milk components from dairy cows.
33433684	1	13	from	cows	179:182	arg1	components					157:166	milk components	152:166	milk components from dairy cows	152:182	Mastitis causes a decrease in milk yield and abnormalities in milk components from dairy cows.
33433684	6	14	theme	transporter-1	836:848	arg1	loss					820:823	a loss	818:823	a loss of glucose transporter-1 and aquaporin-3 at lateral membranes	818:885	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	6	14	theme	transporter-1	836:848	arg1	decrease					893:900	a decrease	891:900	a decrease in milk production in response to LPS treatment	891:948	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	4	15	theme	milk	653:656	arg1	production					658:667	milk production	653:667	milk production	653:667	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	1	16	theme	milk	120:123	arg1	yield					125:129	milk yield	120:129	milk yield	120:129	Mastitis causes a decrease in milk yield and abnormalities in milk components from dairy cows.
33433684	8	17	theme	subcellular	1246:1256	arg1	localization					1258:1269	subcellular localization	1246:1269	subcellular localization	1246:1269	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	0	18	theme	lactating	47:55	arg1	cells					83:87	lactating bovine mammary epithelial cells	47:87	lactating bovine mammary epithelial cells	47:87	Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells.
33433684	9	19	theme	apical	1470:1475	arg1	membranes					1477:1485	the apical membranes	1466:1485	the apical membranes	1466:1485	In contrast, NFκB was concurrently activated with temporal translocation of TLR-4 in the apical membranes, whereas TLR-2 was not significantly influenced by LPS treatment.
33433684	4	20	from	production	658:667	arg1	BMECs					672:676	BMECs	672:676	BMECs	672:676	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	21	theme	immune	459:464	arg1	sensors					466:472	immune sensors	459:472	immune sensors (Toll-like receptors, TLR)	459:499	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	0	22	theme	mammary	64:70	arg1	cells					83:87	lactating bovine mammary epithelial cells	47:87	lactating bovine mammary epithelial cells	47:87	Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells.
33433684	1	23	from	abnormalities	135:147	arg1	cows					179:182	dairy cows	173:182	dairy cows	173:182	Mastitis causes a decrease in milk yield and abnormalities in milk components from dairy cows.
33433684	1	23	from	abnormalities	135:147	arg1	components					157:166	milk components	152:166	milk components from dairy cows	152:182	Mastitis causes a decrease in milk yield and abnormalities in milk components from dairy cows.
33433684	1	23	from	abnormalities	135:147	arg1	yield					125:129	milk yield	120:129	milk yield	120:129	Mastitis causes a decrease in milk yield and abnormalities in milk components from dairy cows.
33433684	6	24	theme	milk	905:908	arg1	production					910:919	milk production	905:919	milk production in response to LPS treatment	905:948	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	8	25	theme	growth	1284:1289	arg1	receptor					1298:1305	epidermal growth factor receptor	1274:1305	epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling	1274:1378	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	7	26	theme	apical	1126:1131	arg1	domains					1142:1148	the apical membrane domains	1122:1148	the apical membrane domains	1122:1148	LPS disrupted the tight junction barrier and caused compositional changes in localization of claudin-3 and claudin-4, although tight junctions were maintained to separate the apical membrane domains and the basolateral membrane domains.
33433684	0	27	from	proteins	35:42	arg1	cells					83:87	lactating bovine mammary epithelial cells	47:87	lactating bovine mammary epithelial cells	47:87	Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells.
33433684	8	28	theme	receptor	1298:1305	arg1	level					1236:1240	expression level	1225:1240	expression level	1225:1240	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	8	28	theme	receptor	1298:1305	arg1	localization					1258:1269	subcellular localization	1246:1269	subcellular localization	1246:1269	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	6	29	from	production	910:919	arg1	response					924:931	response	924:931	response to LPS treatment	924:948	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	8	30	theme	lactating	1310:1318	arg1	BMECs					1320:1324	lactating BMECs	1310:1324	lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling	1310:1378	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	0	31	theme	Adverse	0:6	arg1	effects					8:14	Adverse effects	0:14	Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells	0:87	Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells.
33433684	6	32	from	membranes	877:885	arg1	aquaporin-3					854:864	aquaporin-3	854:864	aquaporin-3	854:864	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	6	32	from	membranes	877:885	arg1	loss					820:823	a loss	818:823	a loss of glucose transporter-1 and aquaporin-3 at lateral membranes	818:885	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	6	32	from	membranes	877:885	arg1	decrease					893:900	a decrease	891:900	a decrease in milk production in response to LPS treatment	891:948	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	6	32	from	membranes	877:885	arg1	transporter-1					836:848	glucose transporter-1	828:848	glucose transporter-1	828:848	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	5	33	theme	membrane	734:741	arg1	proteins					743:750	membrane proteins	734:750	membrane proteins	734:750	In this study, we investigated the influence of LPS on membrane proteins using an in vitro culture model.
33433684	9	34	theme	LPS	1538:1540	arg1	treatment					1542:1550	LPS treatment	1538:1550	LPS treatment	1538:1550	In contrast, NFκB was concurrently activated with temporal translocation of TLR-4 in the apical membranes, whereas TLR-2 was not significantly influenced by LPS treatment.
33433684	7	35	from	changes	1017:1023	arg1	localization					1028:1039	localization	1028:1039	localization of claudin-3 and claudin-4	1028:1066	LPS disrupted the tight junction barrier and caused compositional changes in localization of claudin-3 and claudin-4, although tight junctions were maintained to separate the apical membrane domains and the basolateral membrane domains.
33433684	8	36	theme	detectable	1334:1343	arg1	changes					1345:1351	no detectable changes	1331:1351	no detectable changes in MEK1/2-ERK1/2 signaling	1331:1378	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	10	37	theme	membrane	1641:1648	arg1	proteins					1650:1657	membrane proteins	1641:1657	membrane proteins	1641:1657	These findings indicate the importance of investigating the subcellular localization of membrane proteins to understand the molecular mechanism of LPS in milk production in mastitis.
33433684	7	38	theme	claudin-4	1058:1066	arg1	localization					1028:1039	localization	1028:1039	localization of claudin-3 and claudin-4	1028:1066	LPS disrupted the tight junction barrier and caused compositional changes in localization of claudin-3 and claudin-4, although tight junctions were maintained to separate the apical membrane domains and the basolateral membrane domains.
33433684	4	39	dep	sensors	466:472	arg1	TLR					496:498	TLR	496:498	TLR	496:498	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	39	dep	sensors	466:472	arg1	receptors					485:493	Toll-like receptors	475:493	Toll-like receptors	475:493	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	2	40	theme	mammary	311:317	arg1	BMECs					337:341	BMECs	337:341	BMECs	337:341	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	2	40	theme	mammary	311:317	arg1	cells					330:334	bovine mammary epithelial cells	304:334	bovine mammary epithelial cells (BMECs)	304:342	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	6	41	from	loss	820:823	arg1	membranes					877:885	lateral membranes	869:885	lateral membranes	869:885	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	6	41	from	loss	820:823	arg1	production					910:919	milk production	905:919	milk production in response to LPS treatment	905:948	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	10	42	theme	milk	1707:1710	arg1	production					1712:1721	milk production	1707:1721	milk production in mastitis	1707:1733	These findings indicate the importance of investigating the subcellular localization of membrane proteins to understand the molecular mechanism of LPS in milk production in mastitis.
33433684	6	43	theme	glucose	828:834	arg1	transporter-1					836:848	glucose transporter-1	828:848	glucose transporter-1	828:848	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	7	44	theme	membrane	1133:1140	arg1	domains					1142:1148	the apical membrane domains	1122:1148	the apical membrane domains	1122:1148	LPS disrupted the tight junction barrier and caused compositional changes in localization of claudin-3 and claudin-4, although tight junctions were maintained to separate the apical membrane domains and the basolateral membrane domains.
33433684	10	45	theme	LPS	1700:1702	arg1	mechanism					1687:1695	the molecular mechanism	1673:1695	the molecular mechanism of LPS in milk production in mastitis	1673:1733	These findings indicate the importance of investigating the subcellular localization of membrane proteins to understand the molecular mechanism of LPS in milk production in mastitis.
33433684	8	46	from	BMECs	1320:1324	arg1	level					1236:1240	expression level	1225:1240	expression level	1225:1240	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	8	46	from	BMECs	1320:1324	arg1	localization					1258:1269	subcellular localization	1246:1269	subcellular localization	1246:1269	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	7	47	theme	membrane	1170:1177	arg1	domains					1179:1185	the basolateral membrane domains	1154:1185	the basolateral membrane domains	1154:1185	LPS disrupted the tight junction barrier and caused compositional changes in localization of claudin-3 and claudin-4, although tight junctions were maintained to separate the apical membrane domains and the basolateral membrane domains.
33433684	4	48	theme	glucose	525:531	arg1	sensors					466:472	immune sensors	459:472	immune sensors (Toll-like receptors, TLR)	459:499	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	48	theme	glucose	525:531	arg1	transporters					511:522	nutrient transporters	502:522	nutrient transporters (glucose transporter and aquaporin)	502:558	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	48	theme	glucose	525:531	arg1	transporter					533:543	glucose transporter	525:543	glucose transporter	525:543	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	10	49	from	mechanism	1687:1695	arg1	production					1712:1721	milk production	1707:1721	milk production in mastitis	1707:1733	These findings indicate the importance of investigating the subcellular localization of membrane proteins to understand the molecular mechanism of LPS in milk production in mastitis.
33433684	7	50	theme	compositional	1003:1015	arg1	changes					1017:1023	compositional changes	1003:1023	compositional changes in localization of claudin-3 and claudin-4	1003:1066	LPS disrupted the tight junction barrier and caused compositional changes in localization of claudin-3 and claudin-4, although tight junctions were maintained to separate the apical membrane domains and the basolateral membrane domains.
33433684	2	51	theme	wall	248:251	arg1	component					253:261	cell wall component	243:261	cell wall component	243:261	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	8	52	from	changes	1345:1351	arg1	signaling					1370:1378	MEK1/2-ERK1/2 signaling	1356:1378	MEK1/2-ERK1/2 signaling	1356:1378	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	1	53	theme	milk	152:155	arg1	components					157:166	milk components	152:166	milk components from dairy cows	152:182	Mastitis causes a decrease in milk yield and abnormalities in milk components from dairy cows.
33433684	6	54	theme	mastitis	790:797	arg1	model					799:803	This mastitis model	785:803	This mastitis model	785:803	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	4	55	theme	Toll-like	475:483	arg1	TLR					496:498	TLR	496:498	TLR	496:498	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	55	theme	Toll-like	475:483	arg1	receptors					485:493	Toll-like receptors	475:493	Toll-like receptors	475:493	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	7	56	theme	junction	975:982	arg1	barrier					984:990	the tight junction barrier	965:990	the tight junction barrier	965:990	LPS disrupted the tight junction barrier and caused compositional changes in localization of claudin-3 and claudin-4, although tight junctions were maintained to separate the apical membrane domains and the basolateral membrane domains.
33433684	2	57	theme	milk	285:288	arg1	production					290:299	milk production	285:299	milk production in bovine mammary epithelial cells (BMECs)	285:342	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	8	58	from	level	1236:1240	arg1	BMECs					1320:1324	lactating BMECs	1310:1324	lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling	1310:1378	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	4	59	theme	junction	571:578	arg1	occludin					602:609	occludin	602:609	occludin	602:609	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	59	theme	junction	571:578	arg1	claudin					590:596	claudin	590:596	claudin	590:596	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	59	theme	junction	571:578	arg1	proteins					580:587	tight junction proteins	565:587	tight junction proteins (claudin and occludin)	565:610	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	59	theme	junction	571:578	arg1	sensors					466:472	immune sensors	459:472	immune sensors (Toll-like receptors, TLR)	459:499	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	10	60	theme	molecular	1677:1685	arg1	mechanism					1687:1695	the molecular mechanism	1673:1695	the molecular mechanism of LPS in milk production in mastitis	1673:1733	These findings indicate the importance of investigating the subcellular localization of membrane proteins to understand the molecular mechanism of LPS in milk production in mastitis.
33433684	4	61	theme	membrane	432:439	arg1	sensors					466:472	immune sensors	459:472	immune sensors (Toll-like receptors, TLR)	459:499	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	61	theme	membrane	432:439	arg1	proteins					441:448	Various membrane proteins	424:448	Various membrane proteins	424:448	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	2	62	dep	E.	210:211	arg1	coli					213:216	coli	213:216	coli	213:216	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	9	63	theme	TLR-4	1457:1461	arg1	translocation					1440:1452	temporal translocation	1431:1452	temporal translocation of TLR-4	1431:1461	In contrast, NFκB was concurrently activated with temporal translocation of TLR-4 in the apical membranes, whereas TLR-2 was not significantly influenced by LPS treatment.
33433684	10	64	from	production	1712:1721	arg1	mastitis					1726:1733	mastitis	1726:1733	mastitis	1726:1733	These findings indicate the importance of investigating the subcellular localization of membrane proteins to understand the molecular mechanism of LPS in milk production in mastitis.
33433684	6	65	theme	LPS	936:938	arg1	treatment					940:948	LPS treatment	936:948	LPS treatment	936:948	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	8	66	theme	expression	1225:1234	arg1	level					1236:1240	expression level	1225:1240	expression level	1225:1240	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	0	67	theme	bovine	57:62	arg1	cells					83:87	lactating bovine mammary epithelial cells	47:87	lactating bovine mammary epithelial cells	47:87	Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells.
33433684	0	68	theme	epithelial	72:81	arg1	cells					83:87	lactating bovine mammary epithelial cells	47:87	lactating bovine mammary epithelial cells	47:87	Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells.
33433684	5	69	from	influence	714:722	arg1	proteins					743:750	membrane proteins	734:750	membrane proteins	734:750	In this study, we investigated the influence of LPS on membrane proteins using an in vitro culture model.
33433684	0	70	from	effects	8:14	arg1	proteins					35:42	membrane proteins	26:42	membrane proteins in lactating bovine mammary epithelial cells	26:87	Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells.
33433684	8	71	with	BMECs	1320:1324	arg1	changes					1345:1351	no detectable changes	1331:1351	no detectable changes in MEK1/2-ERK1/2 signaling	1331:1378	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	5	72	dep	in	761:762	arg1	vitro					764:768	vitro	764:768	vitro	764:768	In this study, we investigated the influence of LPS on membrane proteins using an in vitro culture model.
33433684	2	73	from	production	290:299	arg1	BMECs					337:341	BMECs	337:341	BMECs	337:341	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	2	73	from	production	290:299	arg1	cells					330:334	bovine mammary epithelial cells	304:334	bovine mammary epithelial cells (BMECs)	304:342	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	8	74	theme	epidermal	1274:1282	arg1	receptor					1298:1305	epidermal growth factor receptor	1274:1305	epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling	1274:1378	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	4	75	dep	transporters	511:522	arg1	sensors					466:472	immune sensors	459:472	immune sensors (Toll-like receptors, TLR)	459:499	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	75	dep	transporters	511:522	arg1	aquaporin					549:557	aquaporin	549:557	aquaporin	549:557	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	75	dep	transporters	511:522	arg1	transporters					511:522	nutrient transporters	502:522	nutrient transporters (glucose transporter and aquaporin)	502:558	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	75	dep	transporters	511:522	arg1	transporter					533:543	glucose transporter	525:543	glucose transporter	525:543	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	6	76	from	decrease	893:900	arg1	membranes					877:885	lateral membranes	869:885	lateral membranes	869:885	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	6	76	from	decrease	893:900	arg1	production					910:919	milk production	905:919	milk production in response to LPS treatment	905:948	This mastitis model demonstrated a loss of glucose transporter-1 and aquaporin-3 at lateral membranes and a decrease in milk production in response to LPS treatment.
33433684	8	77	theme	factor	1291:1296	arg1	receptor					1298:1305	epidermal growth factor receptor	1274:1305	epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling	1274:1378	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	10	78	theme	subcellular	1613:1623	arg1	localization					1625:1636	the subcellular localization	1609:1636	the subcellular localization of membrane proteins	1609:1657	These findings indicate the importance of investigating the subcellular localization of membrane proteins to understand the molecular mechanism of LPS in milk production in mastitis.
33433684	4	79	from	BMECs	672:676	arg1	onset					632:636	the onset	628:636	the onset of mastitis or milk production in BMECs	628:676	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	3	80	theme	detailed	358:365	arg1	mechanism					367:375	the detailed mechanism	354:375	the detailed mechanism by which this occurs in BMECs	354:405	However, the detailed mechanism by which this occurs in BMECs remains unclear.
33433684	4	81	theme	nutrient	502:509	arg1	sensors					466:472	immune sensors	459:472	immune sensors (Toll-like receptors, TLR)	459:499	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	81	theme	nutrient	502:509	arg1	aquaporin					549:557	aquaporin	549:557	aquaporin	549:557	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	81	theme	nutrient	502:509	arg1	transporters					511:522	nutrient transporters	502:522	nutrient transporters (glucose transporter and aquaporin)	502:558	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	81	theme	nutrient	502:509	arg1	transporter					533:543	glucose transporter	525:543	glucose transporter	525:543	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	82	theme	production	658:667	arg1	onset					632:636	the onset	628:636	the onset of mastitis or milk production in BMECs	628:676	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	7	83	theme	tight	1078:1082	arg1	junctions					1084:1092	tight junctions	1078:1092	tight junctions	1078:1092	LPS disrupted the tight junction barrier and caused compositional changes in localization of claudin-3 and claudin-4, although tight junctions were maintained to separate the apical membrane domains and the basolateral membrane domains.
33433684	5	84	theme	LPS	727:729	arg1	influence					714:722	the influence	710:722	the influence of LPS on membrane proteins	710:750	In this study, we investigated the influence of LPS on membrane proteins using an in vitro culture model.
33433684	1	85	from	decrease	108:115	arg1	cows					179:182	dairy cows	173:182	dairy cows	173:182	Mastitis causes a decrease in milk yield and abnormalities in milk components from dairy cows.
33433684	1	85	from	decrease	108:115	arg1	components					157:166	milk components	152:166	milk components from dairy cows	152:182	Mastitis causes a decrease in milk yield and abnormalities in milk components from dairy cows.
33433684	1	85	from	decrease	108:115	arg1	yield					125:129	milk yield	120:129	milk yield	120:129	Mastitis causes a decrease in milk yield and abnormalities in milk components from dairy cows.
33433684	10	86	theme	proteins	1650:1657	arg1	localization					1625:1636	the subcellular localization	1609:1636	the subcellular localization of membrane proteins	1609:1657	These findings indicate the importance of investigating the subcellular localization of membrane proteins to understand the molecular mechanism of LPS in milk production in mastitis.
33433684	0	87	theme	membrane	26:33	arg1	proteins					35:42	membrane proteins	26:42	membrane proteins in lactating bovine mammary epithelial cells	26:87	Adverse effects of LPS on membrane proteins in lactating bovine mammary epithelial cells.
33433684	2	88	dep	coli	197:200	arg1	component					253:261	cell wall component	243:261	cell wall component	243:261	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	4	89	dep	proteins	580:587	arg1	occludin					602:609	occludin	602:609	occludin	602:609	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	89	dep	proteins	580:587	arg1	claudin					590:596	claudin	590:596	claudin	590:596	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	89	dep	proteins	580:587	arg1	proteins					580:587	tight junction proteins	565:587	tight junction proteins (claudin and occludin)	565:610	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	89	dep	proteins	580:587	arg1	sensors					466:472	immune sensors	459:472	immune sensors (Toll-like receptors, TLR)	459:499	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	2	90	theme	epithelial	319:328	arg1	BMECs					337:341	BMECs	337:341	BMECs	337:341	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	2	90	theme	epithelial	319:328	arg1	cells					330:334	bovine mammary epithelial cells	304:334	bovine mammary epithelial cells (BMECs)	304:342	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	8	91	from	receptor	1298:1305	arg1	BMECs					1320:1324	lactating BMECs	1310:1324	lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling	1310:1378	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	8	92	dep	level	1236:1240	arg1	the					1221:1223	the	1221:1223	the	1221:1223	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	2	93	theme	E.	210:211	arg1	LPS					238:240	LPS	238:240	LPS	238:240	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	2	93	theme	E.	210:211	arg1	lipopolysaccharide					218:235	the E. coli lipopolysaccharide	206:235	the E. coli lipopolysaccharide (LPS)	206:241	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	8	94	theme	MEK1/2-ERK1/2	1356:1368	arg1	signaling					1370:1378	MEK1/2-ERK1/2 signaling	1356:1378	MEK1/2-ERK1/2 signaling	1356:1378	LPS did not significantly affect the expression level and subcellular localization of epidermal growth factor receptor in lactating BMECs with no detectable changes in MEK1/2-ERK1/2 signaling.
33433684	2	95	theme	bovine	304:309	arg1	BMECs					337:341	BMECs	337:341	BMECs	337:341	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	2	95	theme	bovine	304:309	arg1	cells					330:334	bovine mammary epithelial cells	304:334	bovine mammary epithelial cells (BMECs)	304:342	Escherichia coli and the E. coli lipopolysaccharide (LPS) cell wall component directly downregulate milk production in bovine mammary epithelial cells (BMECs).
33433684	4	96	from	mastitis	641:648	arg1	BMECs					672:676	BMECs	672:676	BMECs	672:676	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	9	97	theme	temporal	1431:1438	arg1	translocation					1440:1452	temporal translocation	1431:1452	temporal translocation of TLR-4	1431:1461	In contrast, NFκB was concurrently activated with temporal translocation of TLR-4 in the apical membranes, whereas TLR-2 was not significantly influenced by LPS treatment.
33433684	4	98	theme	tight	565:569	arg1	occludin					602:609	occludin	602:609	occludin	602:609	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	98	theme	tight	565:569	arg1	claudin					590:596	claudin	590:596	claudin	590:596	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	98	theme	tight	565:569	arg1	proteins					580:587	tight junction proteins	565:587	tight junction proteins (claudin and occludin)	565:610	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	4	98	theme	tight	565:569	arg1	sensors					466:472	immune sensors	459:472	immune sensors (Toll-like receptors, TLR)	459:499	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33433684	9	99	dep	activated	1416:1424	arg1	whereas					1488:1494	whereas	1488:1494	whereas	1488:1494	In contrast, NFκB was concurrently activated with temporal translocation of TLR-4 in the apical membranes, whereas TLR-2 was not significantly influenced by LPS treatment.
33433684	4	100	from	onset	632:636	arg1	BMECs					672:676	BMECs	672:676	BMECs	672:676	Various membrane proteins, such as immune sensors (Toll-like receptors, TLR), nutrient transporters (glucose transporter and aquaporin), and tight junction proteins (claudin and occludin) are involved in the onset of mastitis or milk production in BMECs.
33923867	0	0	theme	Colon	80:84	arg1	Patients					93:100	Colon Cancer Patients	80:100	Colon Cancer Patients	80:100	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	5	1	theme	cancer	634:639	arg1	patients					641:648	colon cancer patients	628:648	colon cancer patients	628:648	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	4	2	theme	samples	475:481	arg1	N-glycosylation					443:457	N-glycosylation	443:457	N-glycosylation of cancer tumor samples from the same cohort	443:502	N-glycosylation of cancer tumor samples from the same cohort were further quantified using a similar methodology.
33923867	4	3	theme	tumor	469:473	arg1	samples					475:481	cancer tumor samples	462:481	cancer tumor samples from the same cohort	462:502	N-glycosylation of cancer tumor samples from the same cohort were further quantified using a similar methodology.
33923867	5	4	theme	tetra-antennary	783:797	arg1	HexNAc6Hex7NeuAc3					799:815	the tetra-antennary HexNAc6Hex7NeuAc3	779:815	the tetra-antennary HexNAc6Hex7NeuAc3	779:815	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	4	5	from	cohort	497:502	arg1	samples					475:481	cancer tumor samples	462:481	cancer tumor samples from the same cohort	462:502	N-glycosylation of cancer tumor samples from the same cohort were further quantified using a similar methodology.
33923867	4	5	from	cohort	497:502	arg1	N-glycosylation					443:457	N-glycosylation	443:457	N-glycosylation of cancer tumor samples from the same cohort	443:502	N-glycosylation of cancer tumor samples from the same cohort were further quantified using a similar methodology.
33923867	6	6	theme	clustering	858:867	arg1	analysis					869:876	Hierarchical clustering analysis	845:876	Hierarchical clustering analysis of TSNG	845:884	Hierarchical clustering analysis of TSNG correctly singled out 85% of the patients from controls.
33923867	10	7	theme	different	1544:1552	arg1	origin					1554:1559	a different origin	1542:1559	a different origin of compositions found in serum of cancer patients	1542:1609	However, the compositions profile in serum showed no parallel with N-glycans in tumor microenvironment, which suggests a different origin of compositions found in serum of cancer patients.
33923867	0	8	theme	Patients	93:100	arg1	Tissue					70:75	Tissue	70:75	Tissue	70:75	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	0	8	theme	Patients	93:100	arg1	Serum					60:64	Serum	60:64	Serum	60:64	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	0	9	from	Identification	0:13	arg1	Tissue					70:75	Tissue	70:75	Tissue	70:75	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	0	9	from	Identification	0:13	arg1	Serum					60:64	Serum	60:64	Serum	60:64	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	7	10	theme	oligomannosidic	1020:1034	arg1	compositions					1083:1094	overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions	1004:1094	overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue	1004:1127	Albeit heterogenous, N-glycosylation of tumor samples showed overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue, in both MALDI-TOF/MS and LC-MS analysis.
33923867	6	11	theme	Hierarchical	845:856	arg1	analysis					869:876	Hierarchical clustering analysis	845:876	Hierarchical clustering analysis of TSNG	845:884	Hierarchical clustering analysis of TSNG correctly singled out 85% of the patients from controls.
33923867	2	12	theme	modifications	286:298	arg1	modifications					286:298	the most common posttranslational protein modifications	244:298	the most common posttranslational protein modifications	244:298	N-glycosylation is one of the most common posttranslational protein modifications.
33923867	2	12	theme	modifications	286:298	arg1	one					237:239	one	237:239	one	237:239	N-glycosylation is one of the most common posttranslational protein modifications.
33923867	9	13	theme	patients	1391:1398	arg1	discrimination					1373:1386	the discrimination	1369:1386	the discrimination of patients from healthy controls	1369:1420	Mass spectrometry-based N-glycan profiling in serum shows potential in the discrimination of patients from healthy controls.
33923867	0	14	theme	Cancer	86:91	arg1	Patients					93:100	Colon Cancer Patients	80:100	Colon Cancer Patients	80:100	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	0	15	from	Serum	60:64	arg1	Identification					0:13	Identification	0:13	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.	0:122	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	7	16	theme	samples	989:995	arg1	N-glycosylation					964:978	N-glycosylation	964:978	N-glycosylation of tumor samples	964:995	Albeit heterogenous, N-glycosylation of tumor samples showed overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue, in both MALDI-TOF/MS and LC-MS analysis.
33923867	2	17	theme	protein	278:284	arg1	modifications					286:298	the most common posttranslational protein modifications	244:298	the most common posttranslational protein modifications	244:298	N-glycosylation is one of the most common posttranslational protein modifications.
33923867	0	18	theme	Mass	105:108	arg1	Spectrometry					110:121	Mass Spectrometry	105:121	Mass Spectrometry	105:121	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	4	19	theme	cancer	462:467	arg1	samples					475:481	cancer tumor samples	462:481	cancer tumor samples from the same cohort	462:502	N-glycosylation of cancer tumor samples from the same cohort were further quantified using a similar methodology.
33923867	2	20	theme	posttranslational	260:276	arg1	modifications					286:298	the most common posttranslational protein modifications	244:298	the most common posttranslational protein modifications	244:298	N-glycosylation is one of the most common posttranslational protein modifications.
33923867	10	21	theme	patients	1602:1609	arg1	serum					1586:1590	serum	1586:1590	serum of cancer patients	1586:1609	However, the compositions profile in serum showed no parallel with N-glycans in tumor microenvironment, which suggests a different origin of compositions found in serum of cancer patients.
33923867	9	22	from	discrimination	1373:1386	arg1	controls					1413:1420	healthy controls	1405:1420	healthy controls	1405:1420	Mass spectrometry-based N-glycan profiling in serum shows potential in the discrimination of patients from healthy controls.
33923867	10	23	theme	compositions	1564:1575	arg1	origin					1554:1559	a different origin	1542:1559	a different origin of compositions found in serum of cancer patients	1542:1609	However, the compositions profile in serum showed no parallel with N-glycans in tumor microenvironment, which suggests a different origin of compositions found in serum of cancer patients.
33923867	2	24	theme	common	253:258	arg1	modifications					286:298	the most common posttranslational protein modifications	244:298	the most common posttranslational protein modifications	244:298	N-glycosylation is one of the most common posttranslational protein modifications.
33923867	10	25	dep	showed	1466:1471	arg1	suggests					1533:1540	suggests	1533:1540	suggests a different origin of compositions found in serum of cancer patients	1533:1609	However, the compositions profile in serum showed no parallel with N-glycans in tumor microenvironment, which suggests a different origin of compositions found in serum of cancer patients.
33923867	5	26	theme	glycan	745:750	arg1	HexNAc2Hex7					703:713	the mannose-rich HexNAc2Hex7	686:713	the mannose-rich HexNAc2Hex7	686:713	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	5	26	theme	glycan	745:750	arg1	HexNAc4Hex5Fuc1NeuAc2					752:772	the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2	716:772	the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2	716:772	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	3	27	theme	colon	362:366	arg1	patients					375:382	13 colon cancer patients	359:382	13 colon cancer patients	359:382	Therefore, we studied the total serum N-glycome (TSNG) of 13 colon cancer patients compared to healthy controls using MALDI-TOF/MS and LC-MS.
33923867	0	28	from	Compositions	40:51	arg1	Tissue					70:75	Tissue	70:75	Tissue	70:75	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	0	28	from	Compositions	40:51	arg1	Serum					60:64	Serum	60:64	Serum	60:64	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	7	29	theme	tumor	983:987	arg1	samples					989:995	tumor samples	983:995	tumor samples	983:995	Albeit heterogenous, N-glycosylation of tumor samples showed overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue, in both MALDI-TOF/MS and LC-MS analysis.
33923867	6	30	theme	patients	919:926	arg1	patients					919:926	the patients	915:926	the patients from controls	915:940	Hierarchical clustering analysis of TSNG correctly singled out 85% of the patients from controls.
33923867	6	30	theme	patients	919:926	arg1	%					910:910	85%	908:910	85% of the patients from controls	908:940	Hierarchical clustering analysis of TSNG correctly singled out 85% of the patients from controls.
33923867	3	31	theme	cancer	368:373	arg1	patients					375:382	13 colon cancer patients	359:382	13 colon cancer patients	359:382	Therefore, we studied the total serum N-glycome (TSNG) of 13 colon cancer patients compared to healthy controls using MALDI-TOF/MS and LC-MS.
33923867	5	32	theme	colon	628:632	arg1	patients					641:648	colon cancer patients	628:648	colon cancer patients	628:648	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	10	33	theme	tumor	1503:1507	arg1	microenvironment					1509:1524	tumor microenvironment	1503:1524	tumor microenvironment	1503:1524	However, the compositions profile in serum showed no parallel with N-glycans in tumor microenvironment, which suggests a different origin of compositions found in serum of cancer patients.
33923867	5	34	gly	fucosylated	720:730	arg1	HexNAc2Hex7					703:713	the mannose-rich HexNAc2Hex7	686:713	the mannose-rich HexNAc2Hex7	686:713	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	5	34	gly	fucosylated	720:730	arg1	HexNAc4Hex5Fuc1NeuAc2					752:772	the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2	716:772	the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2	716:772	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	1	35	theme	leading	168:174	arg1	cause					176:180	the leading cause	164:180	the leading cause of cancer-related deaths worldwide	164:215	Colorectal cancer (CRC) ranks second as the leading cause of cancer-related deaths worldwide.
33923867	0	36	theme	N-Glycan	31:38	arg1	Compositions					40:51	Differential N-Glycan Compositions	18:51	Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients	18:100	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	4	37	theme	similar	536:542	arg1	methodology					544:554	a similar methodology	534:554	a similar methodology	534:554	N-glycosylation of cancer tumor samples from the same cohort were further quantified using a similar methodology.
33923867	5	38	theme	mannose-rich	690:701	arg1	HexNAc2Hex7					703:713	the mannose-rich HexNAc2Hex7	686:713	the mannose-rich HexNAc2Hex7	686:713	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	5	38	theme	mannose-rich	690:701	arg1	HexNAc4Hex5Fuc1NeuAc2					752:772	the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2	716:772	the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2	716:772	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	5	39	theme	N-glycan	570:577	arg1	compositions					579:590	23 N-glycan compositions	567:590	23 N-glycan compositions	567:590	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	7	40	theme	overrepresented	1004:1018	arg1	compositions					1083:1094	overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions	1004:1094	overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue	1004:1127	Albeit heterogenous, N-glycosylation of tumor samples showed overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue, in both MALDI-TOF/MS and LC-MS analysis.
33923867	0	41	theme	Differential	18:29	arg1	Compositions					40:51	Differential N-Glycan Compositions	18:51	Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients	18:100	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	4	42	from	N-glycosylation	443:457	arg1	cohort					497:502	the same cohort	488:502	the same cohort	488:502	N-glycosylation of cancer tumor samples from the same cohort were further quantified using a similar methodology.
33923867	9	43	theme	spectrometry-based	1303:1320	arg1	profiling					1331:1339	Mass spectrometry-based N-glycan profiling	1298:1339	Mass spectrometry-based N-glycan profiling in serum	1298:1348	Mass spectrometry-based N-glycan profiling in serum shows potential in the discrimination of patients from healthy controls.
33923867	5	44	theme	patients	641:648	arg1	serum					619:623	the serum	615:623	the serum of colon cancer patients	615:648	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	5	44	theme	patients	641:648	arg1	forms					673:677	mostly galactosylated forms	651:677	mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2	651:772	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	10	45	from	profile	1449:1455	arg1	serum					1460:1464	serum	1460:1464	serum	1460:1464	However, the compositions profile in serum showed no parallel with N-glycans in tumor microenvironment, which suggests a different origin of compositions found in serum of cancer patients.
33923867	8	46	theme	patients	1288:1295	arg1	serum					1272:1276	serum	1272:1276	serum of cancer patients	1272:1295	Moreover, compositions found upregulated in tumor tissue were mostly uncorrelated to compositions in serum of cancer patients.
33923867	9	47	theme	healthy	1405:1411	arg1	controls					1413:1420	healthy controls	1405:1420	healthy controls	1405:1420	Mass spectrometry-based N-glycan profiling in serum shows potential in the discrimination of patients from healthy controls.
33923867	9	48	theme	N-glycan	1322:1329	arg1	profiling					1331:1339	Mass spectrometry-based N-glycan profiling	1298:1339	Mass spectrometry-based N-glycan profiling in serum	1298:1348	Mass spectrometry-based N-glycan profiling in serum shows potential in the discrimination of patients from healthy controls.
33923867	9	49	from	profiling	1331:1339	arg1	serum					1344:1348	serum	1344:1348	serum	1344:1348	Mass spectrometry-based N-glycan profiling in serum shows potential in the discrimination of patients from healthy controls.
33923867	1	50	theme	cancer-related	185:198	arg1	worldwide					207:215	cancer-related deaths worldwide	185:215	cancer-related deaths worldwide	185:215	Colorectal cancer (CRC) ranks second as the leading cause of cancer-related deaths worldwide.
33923867	0	51	theme	Compositions	40:51	arg1	Identification					0:13	Identification	0:13	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.	0:122	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	10	52	with	parallel	1476:1483	arg1	N-glycans					1490:1498	N-glycans	1490:1498	N-glycans	1490:1498	However, the compositions profile in serum showed no parallel with N-glycans in tumor microenvironment, which suggests a different origin of compositions found in serum of cancer patients.
33923867	3	53	theme	healthy	396:402	arg1	controls					404:411	healthy controls	396:411	healthy controls	396:411	Therefore, we studied the total serum N-glycome (TSNG) of 13 colon cancer patients compared to healthy controls using MALDI-TOF/MS and LC-MS.
33923867	0	54	from	Tissue	70:75	arg1	Identification					0:13	Identification	0:13	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.	0:122	Identification of Differential N-Glycan Compositions in the Serum and Tissue of Colon Cancer Patients by Mass Spectrometry.
33923867	6	55	from	%	910:910	arg1	controls					933:940	controls	933:940	controls	933:940	Hierarchical clustering analysis of TSNG correctly singled out 85% of the patients from controls.
33923867	10	56	theme	compositions	1436:1447	arg1	profile					1449:1455	the compositions profile	1432:1455	the compositions profile in serum	1432:1464	However, the compositions profile in serum showed no parallel with N-glycans in tumor microenvironment, which suggests a different origin of compositions found in serum of cancer patients.
33923867	1	57	theme	deaths	200:205	arg1	worldwide					207:215	cancer-related deaths worldwide	185:215	cancer-related deaths worldwide	185:215	Colorectal cancer (CRC) ranks second as the leading cause of cancer-related deaths worldwide.
33923867	3	58	theme	patients	375:382	arg1	TSNG					350:353	TSNG	350:353	TSNG	350:353	Therefore, we studied the total serum N-glycome (TSNG) of 13 colon cancer patients compared to healthy controls using MALDI-TOF/MS and LC-MS.
33923867	3	58	theme	patients	375:382	arg1	N-glycome					339:347	the total serum N-glycome	323:347	the total serum N-glycome (TSNG) of 13 colon cancer patients compared to healthy controls	323:411	Therefore, we studied the total serum N-glycome (TSNG) of 13 colon cancer patients compared to healthy controls using MALDI-TOF/MS and LC-MS.
33923867	5	59	theme	fucosylated	720:730	arg1	HexNAc2Hex7					703:713	the mannose-rich HexNAc2Hex7	686:713	the mannose-rich HexNAc2Hex7	686:713	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	5	59	theme	fucosylated	720:730	arg1	HexNAc4Hex5Fuc1NeuAc2					752:772	the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2	716:772	the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2	716:772	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	5	60	theme	galactosylated	658:671	arg1	forms					673:677	mostly galactosylated forms	651:677	mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2	651:772	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	5	60	theme	galactosylated	658:671	arg1	serum					619:623	the serum	615:623	the serum of colon cancer patients	615:648	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	6	61	from	controls	933:940	arg1	patients					919:926	the patients	915:926	the patients from controls	915:940	Hierarchical clustering analysis of TSNG correctly singled out 85% of the patients from controls.
33923867	6	61	from	controls	933:940	arg1	%					910:910	85%	908:910	85% of the patients from controls	908:940	Hierarchical clustering analysis of TSNG correctly singled out 85% of the patients from controls.
33923867	7	62	theme	related	1096:1102	arg1	compositions					1083:1094	overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions	1004:1094	overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue	1004:1127	Albeit heterogenous, N-glycosylation of tumor samples showed overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue, in both MALDI-TOF/MS and LC-MS analysis.
33923867	8	63	from	compositions	1256:1267	arg1	serum					1272:1276	serum	1272:1276	serum of cancer patients	1272:1295	Moreover, compositions found upregulated in tumor tissue were mostly uncorrelated to compositions in serum of cancer patients.
33923867	10	64	theme	cancer	1595:1600	arg1	patients					1602:1609	cancer patients	1595:1609	cancer patients	1595:1609	However, the compositions profile in serum showed no parallel with N-glycans in tumor microenvironment, which suggests a different origin of compositions found in serum of cancer patients.
33923867	8	65	theme	cancer	1281:1286	arg1	patients					1288:1295	cancer patients	1281:1295	cancer patients	1281:1295	Moreover, compositions found upregulated in tumor tissue were mostly uncorrelated to compositions in serum of cancer patients.
33923867	8	66	theme	tumor	1215:1219	arg1	tissue					1221:1226	tumor tissue	1215:1226	tumor tissue	1215:1226	Moreover, compositions found upregulated in tumor tissue were mostly uncorrelated to compositions in serum of cancer patients.
33923867	6	67	theme	TSNG	881:884	arg1	analysis					869:876	Hierarchical clustering analysis	845:876	Hierarchical clustering analysis of TSNG	845:884	Hierarchical clustering analysis of TSNG correctly singled out 85% of the patients from controls.
33923867	7	68	theme	branched	1074:1081	arg1	compositions					1083:1094	overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions	1004:1094	overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue	1004:1127	Albeit heterogenous, N-glycosylation of tumor samples showed overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue, in both MALDI-TOF/MS and LC-MS analysis.
33923867	1	69	theme	Colorectal	124:133	arg1	CRC					143:145	CRC	143:145	CRC	143:145	Colorectal cancer (CRC) ranks second as the leading cause of cancer-related deaths worldwide.
33923867	1	69	theme	Colorectal	124:133	arg1	cancer					135:140	Colorectal cancer	124:140	Colorectal cancer (CRC)	124:146	Colorectal cancer (CRC) ranks second as the leading cause of cancer-related deaths worldwide.
33923867	1	70	theme	worldwide	207:215	arg1	cause					176:180	the leading cause	164:180	the leading cause of cancer-related deaths worldwide	164:215	Colorectal cancer (CRC) ranks second as the leading cause of cancer-related deaths worldwide.
33923867	7	71	theme	normal	1107:1112	arg1	tissue					1122:1127	normal colonic tissue	1107:1127	normal colonic tissue	1107:1127	Albeit heterogenous, N-glycosylation of tumor samples showed overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue, in both MALDI-TOF/MS and LC-MS analysis.
33923867	7	72	theme	hypogalactosylated	1050:1067	arg1	compositions					1083:1094	overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions	1004:1094	overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue	1004:1127	Albeit heterogenous, N-glycosylation of tumor samples showed overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue, in both MALDI-TOF/MS and LC-MS analysis.
33923867	4	73	gly	N-glycosylation	443:457	arg1	samples					475:481	cancer tumor samples	462:481	cancer tumor samples from the same cohort	462:502	N-glycosylation of cancer tumor samples from the same cohort were further quantified using a similar methodology.
33923867	7	74	theme	LC-MS	1155:1159	arg1	analysis					1161:1168	LC-MS analysis	1155:1168	LC-MS analysis	1155:1168	Albeit heterogenous, N-glycosylation of tumor samples showed overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue, in both MALDI-TOF/MS and LC-MS analysis.
33923867	3	75	theme	total	327:331	arg1	TSNG					350:353	TSNG	350:353	TSNG	350:353	Therefore, we studied the total serum N-glycome (TSNG) of 13 colon cancer patients compared to healthy controls using MALDI-TOF/MS and LC-MS.
33923867	3	75	theme	total	327:331	arg1	N-glycome					339:347	the total serum N-glycome	323:347	the total serum N-glycome (TSNG) of 13 colon cancer patients compared to healthy controls	323:411	Therefore, we studied the total serum N-glycome (TSNG) of 13 colon cancer patients compared to healthy controls using MALDI-TOF/MS and LC-MS.
33923867	7	76	theme	colonic	1114:1120	arg1	tissue					1122:1127	normal colonic tissue	1107:1127	normal colonic tissue	1107:1127	Albeit heterogenous, N-glycosylation of tumor samples showed overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue, in both MALDI-TOF/MS and LC-MS analysis.
33923867	10	77	located	found	1577:1581	arg2	compositions					1564:1575	compositions	1564:1575	compositions found in serum of cancer patients	1564:1609	However, the compositions profile in serum showed no parallel with N-glycans in tumor microenvironment, which suggests a different origin of compositions found in serum of cancer patients.
33923867	10	77	located	found	1577:1581	arg1	serum					1586:1590	serum	1586:1590	serum of cancer patients	1586:1609	However, the compositions profile in serum showed no parallel with N-glycans in tumor microenvironment, which suggests a different origin of compositions found in serum of cancer patients.
33923867	7	78	gly	N-glycosylation	964:978	arg1	samples					989:995	tumor samples	983:995	tumor samples	983:995	Albeit heterogenous, N-glycosylation of tumor samples showed overrepresented oligomannosidic, bi-antennary hypogalactosylated, and branched compositions related to normal colonic tissue, in both MALDI-TOF/MS and LC-MS analysis.
33923867	3	79	theme	serum	333:337	arg1	TSNG					350:353	TSNG	350:353	TSNG	350:353	Therefore, we studied the total serum N-glycome (TSNG) of 13 colon cancer patients compared to healthy controls using MALDI-TOF/MS and LC-MS.
33923867	3	79	theme	serum	333:337	arg1	N-glycome					339:347	the total serum N-glycome	323:347	the total serum N-glycome (TSNG) of 13 colon cancer patients compared to healthy controls	323:411	Therefore, we studied the total serum N-glycome (TSNG) of 13 colon cancer patients compared to healthy controls using MALDI-TOF/MS and LC-MS.
33923867	4	80	theme	same	492:495	arg1	cohort					497:502	the same cohort	488:502	the same cohort	488:502	N-glycosylation of cancer tumor samples from the same cohort were further quantified using a similar methodology.
33923867	8	81	dep	found	1194:1198	arg1	upregulated					1200:1210	upregulated	1200:1210	upregulated in tumor tissue	1200:1226	Moreover, compositions found upregulated in tumor tissue were mostly uncorrelated to compositions in serum of cancer patients.
33923867	8	81	dep	found	1194:1198	arg1	compositions					1181:1192	compositions	1181:1192	compositions found upregulated in tumor tissue	1181:1226	Moreover, compositions found upregulated in tumor tissue were mostly uncorrelated to compositions in serum of cancer patients.
33923867	9	82	from	controls	1413:1420	arg1	patients					1391:1398	patients	1391:1398	patients from healthy controls	1391:1420	Mass spectrometry-based N-glycan profiling in serum shows potential in the discrimination of patients from healthy controls.
33923867	9	82	from	controls	1413:1420	arg1	discrimination					1373:1386	the discrimination	1369:1386	the discrimination of patients from healthy controls	1369:1420	Mass spectrometry-based N-glycan profiling in serum shows potential in the discrimination of patients from healthy controls.
33923867	5	83	theme	bi-antennary	732:743	arg1	HexNAc2Hex7					703:713	the mannose-rich HexNAc2Hex7	686:713	the mannose-rich HexNAc2Hex7	686:713	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
33923867	5	83	theme	bi-antennary	732:743	arg1	HexNAc4Hex5Fuc1NeuAc2					752:772	the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2	716:772	the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2	716:772	In total, 23 N-glycan compositions were down-regulated in the serum of colon cancer patients, mostly galactosylated forms whilst the mannose-rich HexNAc2Hex7, the fucosylated bi-antennary glycan HexNAc4Hex5Fuc1NeuAc2, and the tetra-antennary HexNAc6Hex7NeuAc3 were up-regulated in serum.
32464616	7	0	theme	swelling	1142:1149	arg1	effects					1078:1084	the synergistic effects	1062:1084	the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface	1062:1243	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	7	1	theme	particles	1193:1201	arg1	particles					1131:1139	the highly effective antibacterial ZIF-67 particles	1089:1139	the highly effective antibacterial ZIF-67 particles	1089:1139	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	7	1	theme	particles	1193:1201	arg1	immobilization					1168:1181	immobilization	1168:1181	immobilization of ZIF-67 particles both inside and outside the fiber surface	1168:1243	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	7	1	theme	particles	1193:1201	arg1	swelling					1142:1149	swelling	1142:1149	swelling of alginate	1142:1161	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	3	2	theme	fibers	507:512	arg1	fabrication					437:447	a facile and scalable fabrication	415:447	a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA	415:598	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	7	3	theme	immobilization	1168:1181	arg1	effects					1078:1084	the synergistic effects	1062:1084	the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface	1062:1243	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	8	4	theme	antibacterial	1278:1290	arg1	mechanism					1292:1300	the antibacterial mechanism	1274:1300	the antibacterial mechanism of metal organic frameworks	1274:1328	This work may shed light on the antibacterial mechanism of metal organic frameworks and pave the way for the development of high-performance antibacterial textiles.
32464616	7	5	theme	effective	1100:1108	arg1	particles					1131:1139	the highly effective antibacterial ZIF-67 particles	1089:1139	the highly effective antibacterial ZIF-67 particles	1089:1139	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	7	6	theme	antibacterial	1110:1122	arg1	particles					1131:1139	the highly effective antibacterial ZIF-67 particles	1089:1139	the highly effective antibacterial ZIF-67 particles	1089:1139	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	5	7	theme	SA	720:721	arg1	fibers					733:738	the ZIF-67@SA composite fibers	709:738	the ZIF-67@SA composite fibers	709:738	More importantly, the ZIF-67@SA composite fibers demonstrate excellent antibacterial properties, and the antibacterial efficiency reaches over 99% at ultralow ZIF-67 loading (0.05 wt%).
32464616	7	8	theme	synergistic	1066:1076	arg1	effects					1078:1084	the synergistic effects	1062:1084	the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface	1062:1243	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	3	9	theme	imidazolate	549:559	arg1	particles					583:591	zeolitic imidazolate framework-67 (ZIF-67) particles	540:591	zeolitic imidazolate framework-67 (ZIF-67) particles	540:591	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	6	10	theme	laundering	962:971	arg1	cycles					973:978	five laundering cycles	957:978	five laundering cycles	957:978	In addition, the ZIF-67@SA fibers show good antibacterial durability even after five laundering cycles.
32464616	5	11	theme	composite	723:731	arg1	fibers					733:738	the ZIF-67@SA composite fibers	709:738	the ZIF-67@SA composite fibers	709:738	More importantly, the ZIF-67@SA composite fibers demonstrate excellent antibacterial properties, and the antibacterial efficiency reaches over 99% at ultralow ZIF-67 loading (0.05 wt%).
32464616	4	12	theme	composite	626:634	arg1	fibers					636:641	The fabricated ZIF-67@SA composite fibers	601:641	The fabricated ZIF-67@SA composite fibers	601:641	The fabricated ZIF-67@SA composite fibers show high tensile strength and initial modulus.
32464616	8	13	theme	organic	1311:1317	arg1	frameworks					1319:1328	metal organic frameworks	1305:1328	metal organic frameworks	1305:1328	This work may shed light on the antibacterial mechanism of metal organic frameworks and pave the way for the development of high-performance antibacterial textiles.
32464616	3	14	theme	framework-67	561:572	arg1	particles					583:591	zeolitic imidazolate framework-67 (ZIF-67) particles	540:591	zeolitic imidazolate framework-67 (ZIF-67) particles	540:591	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	3	15	theme	SA	493:494	arg1	fibers					507:512	highly effective antibacterial alginate (SA) composite fibers	452:512	highly effective antibacterial alginate (SA) composite fibers	452:512	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	7	16	theme	fiber	1231:1235	arg1	surface					1237:1243	the fiber surface	1227:1243	the fiber surface	1227:1243	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	5	17	theme	ultralow	841:848	arg1	loading					857:863	ultralow ZIF-67 loading	841:863	ultralow ZIF-67 loading (0.05 wt%)	841:874	More importantly, the ZIF-67@SA composite fibers demonstrate excellent antibacterial properties, and the antibacterial efficiency reaches over 99% at ultralow ZIF-67 loading (0.05 wt%).
32464616	5	17	theme	ultralow	841:848	arg1	%					873:873	0.05 wt%	866:873	0.05 wt%	866:873	More importantly, the ZIF-67@SA composite fibers demonstrate excellent antibacterial properties, and the antibacterial efficiency reaches over 99% at ultralow ZIF-67 loading (0.05 wt%).
32464616	3	18	theme	alginate	483:490	arg1	fibers					507:512	highly effective antibacterial alginate (SA) composite fibers	452:512	highly effective antibacterial alginate (SA) composite fibers	452:512	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	2	19	theme	fabrication	281:291	arg1	method					293:298	the traditional fabrication method	265:298	the traditional fabrication method for the antibacterial fibers	265:327	However, the traditional fabrication method for the antibacterial fibers shows high cost, complexity, and inferior antibacterial durability.
32464616	4	20	theme	initial	674:680	arg1	modulus					682:688	initial modulus	674:688	initial modulus	674:688	The fabricated ZIF-67@SA composite fibers show high tensile strength and initial modulus.
32464616	1	21	theme	surgical	192:199	arg1	sutures					201:207	surgical sutures	192:207	surgical sutures	192:207	Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life.
32464616	7	22	theme	ZIF-67	1124:1129	arg1	particles					1131:1139	the highly effective antibacterial ZIF-67 particles	1089:1139	the highly effective antibacterial ZIF-67 particles	1089:1139	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	7	23	theme	particles	1131:1139	arg1	effects					1078:1084	the synergistic effects	1062:1084	the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface	1062:1243	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	1	24	theme	great	108:112	arg1	potential					114:122	great potential	108:122	great potential	108:122	Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life.
32464616	4	25	theme	tensile	653:659	arg1	strength					661:668	high tensile strength	648:668	high tensile strength	648:668	The fabricated ZIF-67@SA composite fibers show high tensile strength and initial modulus.
32464616	0	26	theme	effective	7:15	arg1	zeolitic					31:38	Highly effective antibacterial zeolitic	0:38	Highly effective antibacterial zeolitic	0:38	Highly effective antibacterial zeolitic imidazolate framework-67/alginate fibers.
32464616	6	27	theme	antibacterial	921:933	arg1	durability					935:944	good antibacterial durability	916:944	good antibacterial durability	916:944	In addition, the ZIF-67@SA fibers show good antibacterial durability even after five laundering cycles.
32464616	7	28	theme	alginate	1154:1161	arg1	particles					1131:1139	the highly effective antibacterial ZIF-67 particles	1089:1139	the highly effective antibacterial ZIF-67 particles	1089:1139	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	7	28	theme	alginate	1154:1161	arg1	immobilization					1168:1181	immobilization	1168:1181	immobilization of ZIF-67 particles both inside and outside the fiber surface	1168:1243	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	7	28	theme	alginate	1154:1161	arg1	swelling					1142:1149	swelling	1142:1149	swelling of alginate	1142:1161	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	4	29	theme	high	648:651	arg1	strength					661:668	high tensile strength	648:668	high tensile strength	648:668	The fabricated ZIF-67@SA composite fibers show high tensile strength and initial modulus.
32464616	3	30	theme	particles	583:591	arg1	SA					597:598	SA	597:598	SA	597:598	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	3	30	theme	particles	583:591	arg1	spinning					528:535	blend spinning	522:535	blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles	522:591	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	8	31	theme	textiles	1401:1408	arg1	development					1355:1365	the development	1351:1365	the development of high-performance antibacterial textiles	1351:1408	This work may shed light on the antibacterial mechanism of metal organic frameworks and pave the way for the development of high-performance antibacterial textiles.
32464616	3	32	theme	scalable	428:435	arg1	fabrication					437:447	a facile and scalable fabrication	415:447	a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA	415:598	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	5	33	theme	ZIF-67	850:855	arg1	loading					857:863	ultralow ZIF-67 loading	841:863	ultralow ZIF-67 loading (0.05 wt%)	841:874	More importantly, the ZIF-67@SA composite fibers demonstrate excellent antibacterial properties, and the antibacterial efficiency reaches over 99% at ultralow ZIF-67 loading (0.05 wt%).
32464616	5	33	theme	ZIF-67	850:855	arg1	%					873:873	0.05 wt%	866:873	0.05 wt%	866:873	More importantly, the ZIF-67@SA composite fibers demonstrate excellent antibacterial properties, and the antibacterial efficiency reaches over 99% at ultralow ZIF-67 loading (0.05 wt%).
32464616	1	34	contain	have	103:106	arg1	fibers					96:101	Antibacterial fibers	82:101	Antibacterial fibers	82:101	Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life.
32464616	1	34	contain	have	103:106	arg2	potential					114:122	great potential	108:122	great potential	108:122	Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life.
32464616	7	35	dep	particles	1193:1201	arg1	both					1203:1206	both	1203:1206	both	1203:1206	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	7	35	dep	particles	1193:1201	arg1	surface					1237:1243	the fiber surface	1227:1243	the fiber surface	1227:1243	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	2	36	theme	antibacterial	308:320	arg1	fibers					322:327	the antibacterial fibers	304:327	the antibacterial fibers	304:327	However, the traditional fabrication method for the antibacterial fibers shows high cost, complexity, and inferior antibacterial durability.
32464616	3	37	theme	antibacterial	469:481	arg1	fibers					507:512	highly effective antibacterial alginate (SA) composite fibers	452:512	highly effective antibacterial alginate (SA) composite fibers	452:512	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	0	38	theme	antibacterial	17:29	arg1	zeolitic					31:38	Highly effective antibacterial zeolitic	0:38	Highly effective antibacterial zeolitic	0:38	Highly effective antibacterial zeolitic imidazolate framework-67/alginate fibers.
32464616	7	39	dep	both	1203:1206	arg1	inside					1208:1213	inside	1208:1213	inside	1208:1213	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	3	40	theme	ZIF-67	575:580	arg1	particles					583:591	zeolitic imidazolate framework-67 (ZIF-67) particles	540:591	zeolitic imidazolate framework-67 (ZIF-67) particles	540:591	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	3	41	theme	blend	522:526	arg1	spinning					528:535	blend spinning	522:535	blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles	522:591	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	0	42	theme	framework-67/alginate	52:72	arg1	fibers					74:79	framework-67/alginate fibers	52:79	framework-67/alginate fibers	52:79	Highly effective antibacterial zeolitic imidazolate framework-67/alginate fibers.
32464616	3	43	theme	composite	497:505	arg1	fibers					507:512	highly effective antibacterial alginate (SA) composite fibers	452:512	highly effective antibacterial alginate (SA) composite fibers	452:512	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	7	44	theme	SA	1035:1036	arg1	fibers					1038:1043	the ZIF-67@SA fibers	1024:1043	the ZIF-67@SA fibers	1024:1043	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	3	45	theme	zeolitic	540:547	arg1	particles					583:591	zeolitic imidazolate framework-67 (ZIF-67) particles	540:591	zeolitic imidazolate framework-67 (ZIF-67) particles	540:591	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	1	46	theme	important	222:230	arg1	role					232:235	an important role	219:235	an important role	219:235	Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life.
32464616	3	47	theme	facile	417:422	arg1	fabrication					437:447	a facile and scalable fabrication	415:447	a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA	415:598	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	6	48	theme	good	916:919	arg1	durability					935:944	good antibacterial durability	916:944	good antibacterial durability	916:944	In addition, the ZIF-67@SA fibers show good antibacterial durability even after five laundering cycles.
32464616	5	49	theme	wt	871:872	arg1	loading					857:863	ultralow ZIF-67 loading	841:863	ultralow ZIF-67 loading (0.05 wt%)	841:874	More importantly, the ZIF-67@SA composite fibers demonstrate excellent antibacterial properties, and the antibacterial efficiency reaches over 99% at ultralow ZIF-67 loading (0.05 wt%).
32464616	5	49	theme	wt	871:872	arg1	%					873:873	0.05 wt%	866:873	0.05 wt%	866:873	More importantly, the ZIF-67@SA composite fibers demonstrate excellent antibacterial properties, and the antibacterial efficiency reaches over 99% at ultralow ZIF-67 loading (0.05 wt%).
32464616	4	50	theme	SA	623:624	arg1	fibers					636:641	The fabricated ZIF-67@SA composite fibers	601:641	The fabricated ZIF-67@SA composite fibers	601:641	The fabricated ZIF-67@SA composite fibers show high tensile strength and initial modulus.
32464616	7	51	theme	antibacterial	995:1007	arg1	performance					1009:1019	The excellent antibacterial performance	981:1019	The excellent antibacterial performance of the ZIF-67@SA fibers	981:1043	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	3	52	theme	effective	459:467	arg1	fibers					507:512	highly effective antibacterial alginate (SA) composite fibers	452:512	highly effective antibacterial alginate (SA) composite fibers	452:512	Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA.
32464616	5	53	theme	antibacterial	796:808	arg1	efficiency					810:819	the antibacterial efficiency	792:819	the antibacterial efficiency	792:819	More importantly, the ZIF-67@SA composite fibers demonstrate excellent antibacterial properties, and the antibacterial efficiency reaches over 99% at ultralow ZIF-67 loading (0.05 wt%).
32464616	8	54	theme	frameworks	1319:1328	arg1	mechanism					1292:1300	the antibacterial mechanism	1274:1300	the antibacterial mechanism of metal organic frameworks	1274:1328	This work may shed light on the antibacterial mechanism of metal organic frameworks and pave the way for the development of high-performance antibacterial textiles.
32464616	8	55	theme	antibacterial	1387:1399	arg1	textiles					1401:1408	high-performance antibacterial textiles	1370:1408	high-performance antibacterial textiles	1370:1408	This work may shed light on the antibacterial mechanism of metal organic frameworks and pave the way for the development of high-performance antibacterial textiles.
32464616	7	56	theme	fibers	1038:1043	arg1	performance					1009:1019	The excellent antibacterial performance	981:1019	The excellent antibacterial performance of the ZIF-67@SA fibers	981:1043	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	5	57	theme	@	719:719	arg1	fibers					733:738	the ZIF-67@SA composite fibers	709:738	the ZIF-67@SA composite fibers	709:738	More importantly, the ZIF-67@SA composite fibers demonstrate excellent antibacterial properties, and the antibacterial efficiency reaches over 99% at ultralow ZIF-67 loading (0.05 wt%).
32464616	7	58	theme	@	1034:1034	arg1	fibers					1038:1043	the ZIF-67@SA fibers	1024:1043	the ZIF-67@SA fibers	1024:1043	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	8	59	theme	high-performance	1370:1385	arg1	textiles					1401:1408	high-performance antibacterial textiles	1370:1408	high-performance antibacterial textiles	1370:1408	This work may shed light on the antibacterial mechanism of metal organic frameworks and pave the way for the development of high-performance antibacterial textiles.
32464616	7	60	theme	ZIF-67	1186:1191	arg1	particles					1193:1201	ZIF-67 particles	1186:1201	ZIF-67 particles both inside and outside the fiber surface	1186:1243	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	1	61	theme	wound	155:159	arg1	dressings					161:169	wound dressings	155:169	wound dressings	155:169	Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life.
32464616	6	62	theme	SA	901:902	arg1	fibers					904:909	the ZIF-67@SA fibers	890:909	the ZIF-67@SA fibers	890:909	In addition, the ZIF-67@SA fibers show good antibacterial durability even after five laundering cycles.
32464616	1	63	theme	surgical	172:179	arg1	gowns					181:185	surgical gowns	172:185	surgical gowns	172:185	Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life.
32464616	7	64	theme	excellent	985:993	arg1	performance					1009:1019	The excellent antibacterial performance	981:1019	The excellent antibacterial performance of the ZIF-67@SA fibers	981:1043	The excellent antibacterial performance of the ZIF-67@SA fibers is attributed to the synergistic effects of the highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles both inside and outside the fiber surface.
32464616	1	65	theme	many	127:130	arg1	dressings					161:169	wound dressings	155:169	wound dressings	155:169	Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life.
32464616	1	65	theme	many	127:130	arg1	gowns					181:185	surgical gowns	172:185	surgical gowns	172:185	Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life.
32464616	1	65	theme	many	127:130	arg1	sutures					201:207	surgical sutures	192:207	surgical sutures	192:207	Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life.
32464616	1	65	theme	many	127:130	arg1	applications					132:143	many applications	127:143	many applications including wound dressings, surgical gowns, and surgical sutures	127:207	Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life.
32464616	4	66	theme	ZIF-67	616:621	arg1	fibers					636:641	The fabricated ZIF-67@SA composite fibers	601:641	The fabricated ZIF-67@SA composite fibers	601:641	The fabricated ZIF-67@SA composite fibers show high tensile strength and initial modulus.
32464616	2	67	theme	traditional	269:279	arg1	method					293:298	the traditional fabrication method	265:298	the traditional fabrication method for the antibacterial fibers	265:327	However, the traditional fabrication method for the antibacterial fibers shows high cost, complexity, and inferior antibacterial durability.
32464616	1	68	theme	Antibacterial	82:94	arg1	fibers					96:101	Antibacterial fibers	82:101	Antibacterial fibers	82:101	Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life.
32464616	2	69	theme	high	335:338	arg1	cost					340:343	high cost	335:343	high cost	335:343	However, the traditional fabrication method for the antibacterial fibers shows high cost, complexity, and inferior antibacterial durability.
32464616	8	70	theme	metal	1305:1309	arg1	frameworks					1319:1328	metal organic frameworks	1305:1328	metal organic frameworks	1305:1328	This work may shed light on the antibacterial mechanism of metal organic frameworks and pave the way for the development of high-performance antibacterial textiles.
32464616	4	71	theme	fabricated	605:614	arg1	fibers					636:641	The fabricated ZIF-67@SA composite fibers	601:641	The fabricated ZIF-67@SA composite fibers	601:641	The fabricated ZIF-67@SA composite fibers show high tensile strength and initial modulus.
32464616	5	72	theme	excellent	752:760	arg1	properties					776:785	excellent antibacterial properties	752:785	excellent antibacterial properties	752:785	More importantly, the ZIF-67@SA composite fibers demonstrate excellent antibacterial properties, and the antibacterial efficiency reaches over 99% at ultralow ZIF-67 loading (0.05 wt%).
32464616	2	73	theme	antibacterial	371:383	arg1	durability					385:394	inferior antibacterial durability	362:394	inferior antibacterial durability	362:394	However, the traditional fabrication method for the antibacterial fibers shows high cost, complexity, and inferior antibacterial durability.
32464616	1	74	theme	daily	244:248	arg1	life					250:253	our daily life	240:253	our daily life	240:253	Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life.
32464616	5	75	theme	antibacterial	762:774	arg1	properties					776:785	excellent antibacterial properties	752:785	excellent antibacterial properties	752:785	More importantly, the ZIF-67@SA composite fibers demonstrate excellent antibacterial properties, and the antibacterial efficiency reaches over 99% at ultralow ZIF-67 loading (0.05 wt%).
32464616	6	76	theme	@	900:900	arg1	fibers					904:909	the ZIF-67@SA fibers	890:909	the ZIF-67@SA fibers	890:909	In addition, the ZIF-67@SA fibers show good antibacterial durability even after five laundering cycles.
32464616	2	77	theme	inferior	362:369	arg1	durability					385:394	inferior antibacterial durability	362:394	inferior antibacterial durability	362:394	However, the traditional fabrication method for the antibacterial fibers shows high cost, complexity, and inferior antibacterial durability.
32464616	4	78	theme	@	622:622	arg1	fibers					636:641	The fabricated ZIF-67@SA composite fibers	601:641	The fabricated ZIF-67@SA composite fibers	601:641	The fabricated ZIF-67@SA composite fibers show high tensile strength and initial modulus.
33124340	6	0	theme	maximum	748:754	arg1	capacity					767:774	The maximum adsorption capacity	744:774	The maximum adsorption capacity	744:774	The maximum adsorption capacity was 289.4 mg·g-1 for an optimal dosage of adsorbents of 1.0 g·L-1.
33124340	6	0	theme	maximum	748:754	arg1	mg·g-1					786:791	289.4 mg·g-1	780:791	289.4 mg·g-1	780:791	The maximum adsorption capacity was 289.4 mg·g-1 for an optimal dosage of adsorbents of 1.0 g·L-1.
33124340	2	1	theme	kinetic	304:310	arg1	characteristics					330:344	the kinetic and thermodynamic characteristics	300:344	the kinetic and thermodynamic characteristics of As(Ⅲ) adsorption	300:364	Batch static experiments were carried out to investigate the kinetic and thermodynamic characteristics of As(Ⅲ) adsorption, and to identify the adsorption mechanism.
33124340	1	2	theme	@	234:234	arg1	GOCS					236:239	Fe@ GOCS	232:239	Fe@ GOCS	232:239	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
33124340	1	2	theme	@	234:234	arg1	particles					221:229	graphene oxide-chitosan coated iron-composite particles	175:229	graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS)	175:240	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
33124340	5	3	theme	298.15	714:719	arg1	temperature					699:709	a temperature	697:709	a temperature of 298.15, 308.15, and 318.15 K	697:741	After approximately 45 h, As(Ⅲ) adsorption reached equilibrium under the conditions of pH 3 and a temperature of 298.15, 308.15, and 318.15 K.
33124340	5	3	theme	298.15	714:719	arg1	pH					688:689	pH 3	688:691	pH 3	688:691	After approximately 45 h, As(Ⅲ) adsorption reached equilibrium under the conditions of pH 3 and a temperature of 298.15, 308.15, and 318.15 K.
33124340	8	4	theme	@	1050:1050	arg1	GOCS					1051:1054	Fe@GOCS	1048:1054	Fe@GOCS	1048:1054	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	11	5	theme	main	1522:1525	arg1	mechanisms					1527:1536	the main mechanisms	1518:1536	the main mechanisms of As(Ⅲ) removal from aqueous solution	1518:1575	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	5	theme	main	1522:1525	arg1	exchange					1479:1486	ion exchange	1475:1486	ion exchange	1475:1486	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	5	theme	main	1522:1525	arg1	complexation					1500:1511	surface complexation	1492:1511	surface complexation	1492:1511	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	3	6	from	iron	433:436	arg1	GOCS					445:448	the GOCS	441:448	the GOCS	441:448	Results showed that the iron on the GOCS was mainly in the form of α-FeO(OH).
33124340	9	7	theme	good	1233:1236	arg1	fit					1238:1240	a good fit	1231:1240	a good fit of the As(Ⅲ) adsorption kinetics for Fe@GOCS	1231:1285	The pseudo-second-order model provided a good fit of the As(Ⅲ) adsorption kinetics for Fe@GOCS.
33124340	6	8	theme	optimal	800:806	arg1	dosage					808:813	an optimal dosage	797:813	an optimal dosage of adsorbents of 1.0 g·L-1	797:840	The maximum adsorption capacity was 289.4 mg·g-1 for an optimal dosage of adsorbents of 1.0 g·L-1.
33124340	2	9	theme	static	249:254	arg1	experiments					256:266	Batch static experiments	243:266	Batch static experiments	243:266	Batch static experiments were carried out to investigate the kinetic and thermodynamic characteristics of As(Ⅲ) adsorption, and to identify the adsorption mechanism.
33124340	8	10	theme	spontaneous	1062:1072	arg1	reaction					1111:1118	a spontaneous, endothermic, and entropy-increasing reaction	1060:1118	a spontaneous, endothermic, and entropy-increasing reaction	1060:1118	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	8	10	theme	spontaneous	1062:1072	arg1	adsorption					1034:1043	As(Ⅲ) adsorption	1028:1043	As(Ⅲ) adsorption on Fe@GOCS	1028:1054	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	5	11	theme	temperature	699:709	arg1	conditions					674:683	the conditions	670:683	the conditions of pH 3 and a temperature of 298.15, 308.15, and 318.15 K	670:741	After approximately 45 h, As(Ⅲ) adsorption reached equilibrium under the conditions of pH 3 and a temperature of 298.15, 308.15, and 318.15 K.
33124340	8	12	theme	endothermic	1075:1085	arg1	reaction					1111:1118	a spontaneous, endothermic, and entropy-increasing reaction	1060:1118	a spontaneous, endothermic, and entropy-increasing reaction	1060:1118	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	8	12	theme	endothermic	1075:1085	arg1	adsorption					1034:1043	As(Ⅲ) adsorption	1028:1043	As(Ⅲ) adsorption on Fe@GOCS	1028:1054	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	10	13	theme	adsorption	1329:1338	arg1	data					1353:1356	adsorption experimental data	1329:1356	adsorption experimental data	1329:1356	Compared to the Langmuir isotherm, As(Ⅲ) adsorption experimental data fitted better to the Freundlich and Sips models.
33124340	7	14	theme	adsorption-desorption	872:892	arg1	times					854:858	five times	849:858	five times of repeated adsorption-desorption	849:892	After five times of repeated adsorption-desorption, the adsorption capacity increased slightly.
33124340	9	15	theme	Ⅲ	1252:1252	arg1	kinetics					1266:1273	the As(Ⅲ) adsorption kinetics	1245:1273	the As(Ⅲ) adsorption kinetics	1245:1273	The pseudo-second-order model provided a good fit of the As(Ⅲ) adsorption kinetics for Fe@GOCS.
33124340	10	16	dep	Compared	1288:1295	arg1	As					1323:1324	As	1323:1324	As	1323:1324	Compared to the Langmuir isotherm, As(Ⅲ) adsorption experimental data fitted better to the Freundlich and Sips models.
33124340	9	17	theme	adsorption	1255:1264	arg1	kinetics					1266:1273	the As(Ⅲ) adsorption kinetics	1245:1273	the As(Ⅲ) adsorption kinetics	1245:1273	The pseudo-second-order model provided a good fit of the As(Ⅲ) adsorption kinetics for Fe@GOCS.
33124340	5	18	theme	pH	688:689	arg1	conditions					674:683	the conditions	670:683	the conditions of pH 3 and a temperature of 298.15, 308.15, and 318.15 K	670:741	After approximately 45 h, As(Ⅲ) adsorption reached equilibrium under the conditions of pH 3 and a temperature of 298.15, 308.15, and 318.15 K.
33124340	1	19	theme	graphene	112:119	arg1	oxide					121:125	graphene oxide	112:125	graphene oxide	112:125	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
33124340	6	20	theme	g·L-1	836:840	arg1	adsorbents					818:827	adsorbents	818:827	adsorbents of 1.0 g·L-1	818:840	The maximum adsorption capacity was 289.4 mg·g-1 for an optimal dosage of adsorbents of 1.0 g·L-1.
33124340	11	21	theme	surface	1492:1498	arg1	mechanisms					1527:1536	the main mechanisms	1518:1536	the main mechanisms of As(Ⅲ) removal from aqueous solution	1518:1575	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	21	theme	surface	1492:1498	arg1	exchange					1479:1486	ion exchange	1475:1486	ion exchange	1475:1486	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	21	theme	surface	1492:1498	arg1	complexation					1500:1511	surface complexation	1492:1511	surface complexation	1492:1511	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	0	22	theme	Graphene	45:52	arg1	Oxide-Chitosan					54:67	Iron-loaded Graphene Oxide-Chitosan	33:67	Iron-loaded Graphene Oxide-Chitosan	33:67	[Adsorption of As(Ⅲ) in Water by Iron-loaded Graphene Oxide-Chitosan].
33124340	5	23	theme	K	741:741	arg1	temperature					699:709	a temperature	697:709	a temperature of 298.15, 308.15, and 318.15 K	697:741	After approximately 45 h, As(Ⅲ) adsorption reached equilibrium under the conditions of pH 3 and a temperature of 298.15, 308.15, and 318.15 K.
33124340	5	23	theme	K	741:741	arg1	pH					688:689	pH 3	688:691	pH 3	688:691	After approximately 45 h, As(Ⅲ) adsorption reached equilibrium under the conditions of pH 3 and a temperature of 298.15, 308.15, and 318.15 K.
33124340	0	24	from	[Adsorption	0:10	arg1	Water					24:28	Water	24:28	Water	24:28	[Adsorption of As(Ⅲ) in Water by Iron-loaded Graphene Oxide-Chitosan].
33124340	1	25	theme	self-assembly	97:109	arg1	principle					84:92	the principle	80:92	the principle of self-assembly	80:109	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
33124340	10	26	theme	Freundlich	1379:1388	arg1	models					1399:1404	the Freundlich and Sips models	1375:1404	the Freundlich and Sips models	1375:1404	Compared to the Langmuir isotherm, As(Ⅲ) adsorption experimental data fitted better to the Freundlich and Sips models.
33124340	9	27	theme	pseudo-second-order	1196:1214	arg1	model					1216:1220	The pseudo-second-order model	1192:1220	The pseudo-second-order model	1192:1220	The pseudo-second-order model provided a good fit of the As(Ⅲ) adsorption kinetics for Fe@GOCS.
33124340	2	28	theme	adsorption	387:396	arg1	mechanism					398:406	the adsorption mechanism	383:406	the adsorption mechanism	383:406	Batch static experiments were carried out to investigate the kinetic and thermodynamic characteristics of As(Ⅲ) adsorption, and to identify the adsorption mechanism.
33124340	0	29	theme	Iron-loaded	33:43	arg1	Oxide-Chitosan					54:67	Iron-loaded Graphene Oxide-Chitosan	33:67	Iron-loaded Graphene Oxide-Chitosan	33:67	[Adsorption of As(Ⅲ) in Water by Iron-loaded Graphene Oxide-Chitosan].
33124340	2	30	theme	As	349:350	arg1	adsorption					355:364	As(Ⅲ) adsorption	349:364	As(Ⅲ) adsorption	349:364	Batch static experiments were carried out to investigate the kinetic and thermodynamic characteristics of As(Ⅲ) adsorption, and to identify the adsorption mechanism.
33124340	0	31	theme	As	15:16	arg1	[Adsorption					0:10	[Adsorption	0:10	[Adsorption of As(Ⅲ) in Water by Iron-loaded Graphene Oxide-Chitosan	0:67	[Adsorption of As(Ⅲ) in Water by Iron-loaded Graphene Oxide-Chitosan].
33124340	10	32	theme	Sips	1394:1397	arg1	models					1399:1404	the Freundlich and Sips models	1375:1404	the Freundlich and Sips models	1375:1404	Compared to the Langmuir isotherm, As(Ⅲ) adsorption experimental data fitted better to the Freundlich and Sips models.
33124340	2	33	dep	adsorption	355:364	arg1	Ⅲ					352:352	Ⅲ	352:352	Ⅲ	352:352	Batch static experiments were carried out to investigate the kinetic and thermodynamic characteristics of As(Ⅲ) adsorption, and to identify the adsorption mechanism.
33124340	2	34	theme	adsorption	355:364	arg1	characteristics					330:344	the kinetic and thermodynamic characteristics	300:344	the kinetic and thermodynamic characteristics of As(Ⅲ) adsorption	300:364	Batch static experiments were carried out to investigate the kinetic and thermodynamic characteristics of As(Ⅲ) adsorption, and to identify the adsorption mechanism.
33124340	8	35	theme	thermodynamic	943:955	arg1	parameters					957:966	The thermodynamic parameters	939:966	The thermodynamic parameters	939:966	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	1	36	theme	graphene	175:182	arg1	GOCS					236:239	Fe@ GOCS	232:239	Fe@ GOCS	232:239	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
33124340	1	36	theme	graphene	175:182	arg1	particles					221:229	graphene oxide-chitosan coated iron-composite particles	175:229	graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS)	175:240	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
33124340	4	37	theme	adsorption	563:572	arg1	capacity					574:581	the highest adsorption capacity	551:581	the highest adsorption capacity	551:581	The As(Ⅲ) adsorption capacity increased with decreasing pH, and the highest adsorption capacity occurred at pH 3.
33124340	4	38	theme	Ⅲ	494:494	arg1	capacity					508:515	The As(Ⅲ) adsorption capacity	487:515	The As(Ⅲ) adsorption capacity	487:515	The As(Ⅲ) adsorption capacity increased with decreasing pH, and the highest adsorption capacity occurred at pH 3.
33124340	11	39	theme	Fe	1583:1584	arg1	GOCS					1586:1589	Fe@GOCS	1583:1589	Fe@GOCS	1583:1589	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	1	40	theme	coated	199:204	arg1	GOCS					236:239	Fe@ GOCS	232:239	Fe@ GOCS	232:239	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
33124340	1	40	theme	coated	199:204	arg1	particles					221:229	graphene oxide-chitosan coated iron-composite particles	175:229	graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS)	175:240	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
33124340	6	41	theme	adsorption	756:765	arg1	capacity					767:774	The maximum adsorption capacity	744:774	The maximum adsorption capacity	744:774	The maximum adsorption capacity was 289.4 mg·g-1 for an optimal dosage of adsorbents of 1.0 g·L-1.
33124340	6	41	theme	adsorption	756:765	arg1	mg·g-1					786:791	289.4 mg·g-1	780:791	289.4 mg·g-1	780:791	The maximum adsorption capacity was 289.4 mg·g-1 for an optimal dosage of adsorbents of 1.0 g·L-1.
33124340	4	42	theme	adsorption	497:506	arg1	capacity					508:515	The As(Ⅲ) adsorption capacity	487:515	The As(Ⅲ) adsorption capacity	487:515	The As(Ⅲ) adsorption capacity increased with decreasing pH, and the highest adsorption capacity occurred at pH 3.
33124340	8	43	theme	ΔSθ	987:989	arg1	>					991:991	ΔSθ > 0	987:993	ΔSθ > 0	987:993	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	10	44	dep	fitted	1358:1363	arg1	Ⅲ					1326:1326	Ⅲ	1326:1326	Ⅲ	1326:1326	Compared to the Langmuir isotherm, As(Ⅲ) adsorption experimental data fitted better to the Freundlich and Sips models.
33124340	2	45	theme	Batch	243:247	arg1	experiments					256:266	Batch static experiments	243:266	Batch static experiments	243:266	Batch static experiments were carried out to investigate the kinetic and thermodynamic characteristics of As(Ⅲ) adsorption, and to identify the adsorption mechanism.
33124340	1	46	theme	Fe	232:233	arg1	GOCS					236:239	Fe@ GOCS	232:239	Fe@ GOCS	232:239	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
33124340	1	46	theme	Fe	232:233	arg1	particles					221:229	graphene oxide-chitosan coated iron-composite particles	175:229	graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS)	175:240	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
33124340	9	47	theme	Fe	1279:1280	arg1	GOCS					1282:1285	Fe@GOCS	1279:1285	Fe@GOCS	1279:1285	The pseudo-second-order model provided a good fit of the As(Ⅲ) adsorption kinetics for Fe@GOCS.
33124340	4	48	theme	As	491:492	arg1	capacity					508:515	The As(Ⅲ) adsorption capacity	487:515	The As(Ⅲ) adsorption capacity	487:515	The As(Ⅲ) adsorption capacity increased with decreasing pH, and the highest adsorption capacity occurred at pH 3.
33124340	10	49	theme	Langmuir	1304:1311	arg1	isotherm					1313:1320	the Langmuir isotherm	1300:1320	the Langmuir isotherm	1300:1320	Compared to the Langmuir isotherm, As(Ⅲ) adsorption experimental data fitted better to the Freundlich and Sips models.
33124340	4	50	theme	highest	555:561	arg1	capacity					574:581	the highest adsorption capacity	551:581	the highest adsorption capacity	551:581	The As(Ⅲ) adsorption capacity increased with decreasing pH, and the highest adsorption capacity occurred at pH 3.
33124340	11	51	from	mechanisms	1527:1536	arg1	solution					1568:1575	aqueous solution	1560:1575	aqueous solution	1560:1575	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	8	52	theme	Fe	1048:1049	arg1	GOCS					1051:1054	Fe@GOCS	1048:1054	Fe@GOCS	1048:1054	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	7	53	theme	adsorption	899:908	arg1	capacity					910:917	the adsorption capacity	895:917	the adsorption capacity	895:917	After five times of repeated adsorption-desorption, the adsorption capacity increased slightly.
33124340	3	54	theme	α-FeO	476:480	arg1	form					468:471	the form	464:471	the form of α-FeO(OH)	464:484	Results showed that the iron on the GOCS was mainly in the form of α-FeO(OH).
33124340	11	55	with	combination	1410:1420	arg1	results					1448:1454	the characterization results	1427:1454	the characterization results	1427:1454	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	9	56	theme	@	1281:1281	arg1	GOCS					1282:1285	Fe@GOCS	1279:1285	Fe@GOCS	1279:1285	The pseudo-second-order model provided a good fit of the As(Ⅲ) adsorption kinetics for Fe@GOCS.
33124340	5	57	theme	308.15	722:727	arg1	temperature					699:709	a temperature	697:709	a temperature of 298.15, 308.15, and 318.15 K	697:741	After approximately 45 h, As(Ⅲ) adsorption reached equilibrium under the conditions of pH 3 and a temperature of 298.15, 308.15, and 318.15 K.
33124340	5	57	theme	308.15	722:727	arg1	pH					688:689	pH 3	688:691	pH 3	688:691	After approximately 45 h, As(Ⅲ) adsorption reached equilibrium under the conditions of pH 3 and a temperature of 298.15, 308.15, and 318.15 K.
33124340	8	58	theme	As	1028:1029	arg1	reaction					1111:1118	a spontaneous, endothermic, and entropy-increasing reaction	1060:1118	a spontaneous, endothermic, and entropy-increasing reaction	1060:1118	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	8	58	theme	As	1028:1029	arg1	adsorption					1034:1043	As(Ⅲ) adsorption	1028:1043	As(Ⅲ) adsorption on Fe@GOCS	1028:1054	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	10	59	theme	experimental	1340:1351	arg1	data					1353:1356	adsorption experimental data	1329:1356	adsorption experimental data	1329:1356	Compared to the Langmuir isotherm, As(Ⅲ) adsorption experimental data fitted better to the Freundlich and Sips models.
33124340	7	60	theme	repeated	863:870	arg1	adsorption-desorption					872:892	repeated adsorption-desorption	863:892	repeated adsorption-desorption	863:892	After five times of repeated adsorption-desorption, the adsorption capacity increased slightly.
33124340	11	61	theme	As	1541:1542	arg1	removal					1547:1553	As(Ⅲ) removal	1541:1553	As(Ⅲ) removal from aqueous solution	1541:1575	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	8	62	from	adsorption	1034:1043	arg1	GOCS					1051:1054	Fe@GOCS	1048:1054	Fe@GOCS	1048:1054	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	11	63	theme	ion	1475:1477	arg1	mechanisms					1527:1536	the main mechanisms	1518:1536	the main mechanisms of As(Ⅲ) removal from aqueous solution	1518:1575	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	63	theme	ion	1475:1477	arg1	exchange					1479:1486	ion exchange	1475:1486	ion exchange	1475:1486	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	63	theme	ion	1475:1477	arg1	complexation					1500:1511	surface complexation	1492:1511	surface complexation	1492:1511	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	5	64	theme	As	627:628	arg1	adsorption					633:642	As(Ⅲ) adsorption	627:642	As(Ⅲ) adsorption	627:642	After approximately 45 h, As(Ⅲ) adsorption reached equilibrium under the conditions of pH 3 and a temperature of 298.15, 308.15, and 318.15 K.
33124340	9	65	theme	kinetics	1266:1273	arg1	fit					1238:1240	a good fit	1231:1240	a good fit of the As(Ⅲ) adsorption kinetics for Fe@GOCS	1231:1285	The pseudo-second-order model provided a good fit of the As(Ⅲ) adsorption kinetics for Fe@GOCS.
33124340	8	66	theme	entropy-increasing	1092:1109	arg1	reaction					1111:1118	a spontaneous, endothermic, and entropy-increasing reaction	1060:1118	a spontaneous, endothermic, and entropy-increasing reaction	1060:1118	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	8	66	theme	entropy-increasing	1092:1109	arg1	adsorption					1034:1043	As(Ⅲ) adsorption	1028:1043	As(Ⅲ) adsorption on Fe@GOCS	1028:1054	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	5	67	theme	Ⅲ	630:630	arg1	adsorption					633:642	As(Ⅲ) adsorption	627:642	As(Ⅲ) adsorption	627:642	After approximately 45 h, As(Ⅲ) adsorption reached equilibrium under the conditions of pH 3 and a temperature of 298.15, 308.15, and 318.15 K.
33124340	5	68	theme	318.15	734:739	arg1	K					741:741	318.15 K	734:741	318.15 K	734:741	After approximately 45 h, As(Ⅲ) adsorption reached equilibrium under the conditions of pH 3 and a temperature of 298.15, 308.15, and 318.15 K.
33124340	11	69	from	solution	1568:1575	arg1	mechanisms					1527:1536	the main mechanisms	1518:1536	the main mechanisms of As(Ⅲ) removal from aqueous solution	1518:1575	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	69	from	solution	1568:1575	arg1	removal					1547:1553	As(Ⅲ) removal	1541:1553	As(Ⅲ) removal from aqueous solution	1541:1575	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	69	from	solution	1568:1575	arg1	exchange					1479:1486	ion exchange	1475:1486	ion exchange	1475:1486	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	69	from	solution	1568:1575	arg1	complexation					1500:1511	surface complexation	1492:1511	surface complexation	1492:1511	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	6	70	theme	adsorbents	818:827	arg1	dosage					808:813	an optimal dosage	797:813	an optimal dosage of adsorbents of 1.0 g·L-1	797:840	The maximum adsorption capacity was 289.4 mg·g-1 for an optimal dosage of adsorbents of 1.0 g·L-1.
33124340	0	71	from	Water	24:28	arg1	[Adsorption					0:10	[Adsorption	0:10	[Adsorption of As(Ⅲ) in Water by Iron-loaded Graphene Oxide-Chitosan	0:67	[Adsorption of As(Ⅲ) in Water by Iron-loaded Graphene Oxide-Chitosan].
33124340	11	72	dep	As	1541:1542	arg1	Ⅲ					1544:1544	Ⅲ	1544:1544	Ⅲ	1544:1544	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	8	73	theme	higher	1132:1137	arg1	temperature					1139:1149	a higher temperature	1130:1149	a higher temperature	1130:1149	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	8	73	theme	higher	1132:1137	arg1	favorable					1160:1168	favorable	1160:1168	favorable	1160:1168	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	8	74	dep	As	1028:1029	arg1	Ⅲ					1031:1031	Ⅲ	1031:1031	Ⅲ	1031:1031	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	8	75	theme	As	1174:1175	arg1	adsorption					1180:1189	As(Ⅲ) adsorption	1174:1189	As(Ⅲ) adsorption	1174:1189	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	2	76	theme	thermodynamic	316:328	arg1	characteristics					330:344	the kinetic and thermodynamic characteristics	300:344	the kinetic and thermodynamic characteristics of As(Ⅲ) adsorption	300:364	Batch static experiments were carried out to investigate the kinetic and thermodynamic characteristics of As(Ⅲ) adsorption, and to identify the adsorption mechanism.
33124340	8	77	theme	Ⅲ	1177:1177	arg1	adsorption					1180:1189	As(Ⅲ) adsorption	1174:1189	As(Ⅲ) adsorption	1174:1189	The thermodynamic parameters showed that ΔGθ<0, ΔSθ > 0, and ΔHθ>0, thus indicating that As(Ⅲ) adsorption on Fe@GOCS was a spontaneous, endothermic, and entropy-increasing reaction, and that a higher temperature was more favorable for As(Ⅲ) adsorption.
33124340	11	78	theme	aqueous	1560:1566	arg1	solution					1568:1575	aqueous solution	1560:1575	aqueous solution	1560:1575	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	79	theme	characterization	1431:1446	arg1	results					1448:1454	the characterization results	1427:1454	the characterization results	1427:1454	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	80	theme	removal	1547:1553	arg1	mechanisms					1527:1536	the main mechanisms	1518:1536	the main mechanisms of As(Ⅲ) removal from aqueous solution	1518:1575	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	80	theme	removal	1547:1553	arg1	exchange					1479:1486	ion exchange	1475:1486	ion exchange	1475:1486	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	80	theme	removal	1547:1553	arg1	complexation					1500:1511	surface complexation	1492:1511	surface complexation	1492:1511	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	1	81	theme	oxide-chitosan	184:197	arg1	GOCS					236:239	Fe@ GOCS	232:239	Fe@ GOCS	232:239	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
33124340	1	81	theme	oxide-chitosan	184:197	arg1	particles					221:229	graphene oxide-chitosan coated iron-composite particles	175:229	graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS)	175:240	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
33124340	9	82	theme	As	1249:1250	arg1	kinetics					1266:1273	the As(Ⅲ) adsorption kinetics	1245:1273	the As(Ⅲ) adsorption kinetics	1245:1273	The pseudo-second-order model provided a good fit of the As(Ⅲ) adsorption kinetics for Fe@GOCS.
33124340	11	83	located	found	1464:1468	arg2	it					1457:1458	it	1457:1458	it	1457:1458	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	83	located	found	1464:1468	arg1	combination					1410:1420	combination	1410:1420	combination with the characterization results	1410:1454	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	11	84	theme	@	1585:1585	arg1	GOCS					1586:1589	Fe@GOCS	1583:1589	Fe@GOCS	1583:1589	In combination with the characterization results, it was found that ion exchange and surface complexation were the main mechanisms of As(Ⅲ) removal from aqueous solution using Fe@GOCS.
33124340	1	85	theme	iron-composite	206:219	arg1	GOCS					236:239	Fe@ GOCS	232:239	Fe@ GOCS	232:239	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
33124340	1	85	theme	iron-composite	206:219	arg1	particles					221:229	graphene oxide-chitosan coated iron-composite particles	175:229	graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS)	175:240	Based on the principle of self-assembly, graphene oxide, chitosan, and FeCl3·6H2O were mixed to prepare graphene oxide-chitosan coated iron-composite particles (Fe@ GOCS).
34562534	4	0	theme	porous	824:829	arg1	structures					831:840	porous structures	824:840	porous structures	824:840	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	4	1	theme	important	667:675	arg1	role					677:680	a more important role	660:680	a more important role	660:680	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	1	2	theme	colloidal	265:273	arg1	particles					275:283	colloidal particles	265:283	colloidal particles	265:283	Stabilities of cellulose Pickering emulsions are of great importance to utilize them effectively, but influenced by their complex compositions, such as, colloidal particles, oil phases and water phases.
34562534	5	3	theme	innovative	854:863	arg1	This					843:846	This	843:846	This	843:846	This is an innovative method that different forms of target products are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems.
34562534	5	3	theme	innovative	854:863	arg1	method					865:870	an innovative method	851:870	an innovative method that different forms of target products are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems	851:1068	This is an innovative method that different forms of target products are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems.
34562534	5	4	theme	three-phase	949:959	arg1	diagram					961:967	three-phase diagram	949:967	three-phase diagram	949:967	This is an innovative method that different forms of target products are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems.
34562534	4	5	theme	storage	713:719	arg1	stability					721:729	storage stability	713:729	storage stability	713:729	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	5	6	theme	other	1037:1041	arg1	systems					1062:1068	other Pickering emulsion systems	1037:1068	other Pickering emulsion systems	1037:1068	This is an innovative method that different forms of target products are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems.
34562534	4	7	theme	structures	831:840	arg1	number					814:819	a large number	806:819	a large number of porous structures	806:840	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	1	8	theme	oil	286:288	arg1	phases					290:295	oil phases	286:295	oil phases	286:295	Stabilities of cellulose Pickering emulsions are of great importance to utilize them effectively, but influenced by their complex compositions, such as, colloidal particles, oil phases and water phases.
34562534	2	9	theme	polymerization	355:368	arg1	products					370:377	solid-liquid controllable polymerization products	329:377	solid-liquid controllable polymerization products	329:377	In this work, solid-liquid controllable polymerization products could obtain by adjusting cellulose nanocrystals (CNCs) concentration and vinyl acetate (VAc)-water ratio.
34562534	5	10	dep	method	865:870	arg1	obtained					916:923	obtained	916:923	are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems	912:1068	This is an innovative method that different forms of target products are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems.
34562534	5	11	theme	emulsion	1053:1060	arg1	systems					1062:1068	other Pickering emulsion systems	1037:1068	other Pickering emulsion systems	1037:1068	This is an innovative method that different forms of target products are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems.
34562534	2	12	theme	nanocrystals	415:426	arg1	concentration					435:447	cellulose nanocrystals (CNCs) concentration	405:447	cellulose nanocrystals (CNCs) concentration	405:447	In this work, solid-liquid controllable polymerization products could obtain by adjusting cellulose nanocrystals (CNCs) concentration and vinyl acetate (VAc)-water ratio.
34562534	4	13	dep	stability	721:729	arg1	the					709:711	the	709:711	the	709:711	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	3	14	from	emulsions	490:498	arg1	o/w					524:526	o/w	524:526	o/w	524:526	The emulsions in zone Ӏ (w/o) and II (o/w) of the three-phase diagram were selected for researching.
34562534	3	14	from	emulsions	490:498	arg1	zone					503:506	zone Ӏ	503:508	zone Ӏ (w/o)	503:514	The emulsions in zone Ӏ (w/o) and II (o/w) of the three-phase diagram were selected for researching.
34562534	3	14	from	emulsions	490:498	arg1	w/o					511:513	w/o	511:513	w/o	511:513	The emulsions in zone Ӏ (w/o) and II (o/w) of the three-phase diagram were selected for researching.
34562534	3	14	from	emulsions	490:498	arg1	II					520:521	II	520:521	II (o/w)	520:527	The emulsions in zone Ӏ (w/o) and II (o/w) of the three-phase diagram were selected for researching.
34562534	5	15	theme	Pickering	1043:1051	arg1	systems					1062:1068	other Pickering emulsion systems	1037:1068	other Pickering emulsion systems	1037:1068	This is an innovative method that different forms of target products are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems.
34562534	2	16	theme	cellulose	405:413	arg1	nanocrystals					415:426	cellulose nanocrystals	405:426	cellulose nanocrystals (CNCs) concentration	405:447	In this work, solid-liquid controllable polymerization products could obtain by adjusting cellulose nanocrystals (CNCs) concentration and vinyl acetate (VAc)-water ratio.
34562534	2	16	theme	cellulose	405:413	arg1	CNCs					429:432	CNCs	429:432	CNCs	429:432	In this work, solid-liquid controllable polymerization products could obtain by adjusting cellulose nanocrystals (CNCs) concentration and vinyl acetate (VAc)-water ratio.
34562534	4	17	theme	CNCs	687:690	arg1	concentration					692:704	CNCs concentration	687:704	CNCs concentration in the storage stability and practicality of the polymerized emulsion	687:774	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	3	18	theme	three-phase	536:546	arg1	diagram					548:554	the three-phase diagram	532:554	the three-phase diagram	532:554	The emulsions in zone Ӏ (w/o) and II (o/w) of the three-phase diagram were selected for researching.
34562534	4	19	theme	o/w	643:645	arg1	ratio					647:651	the o/w ratio	639:651	the o/w ratio	639:651	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	4	20	theme	zone	792:795	arg1	Ӏ					797:797	zone Ӏ	792:797	zone Ӏ	792:797	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	1	21	theme	cellulose	127:135	arg1	emulsions					147:155	cellulose Pickering emulsions	127:155	cellulose Pickering emulsions	127:155	Stabilities of cellulose Pickering emulsions are of great importance to utilize them effectively, but influenced by their complex compositions, such as, colloidal particles, oil phases and water phases.
34562534	2	22	theme	vinyl	453:457	arg1	VAc					468:470	VAc	468:470	VAc	468:470	In this work, solid-liquid controllable polymerization products could obtain by adjusting cellulose nanocrystals (CNCs) concentration and vinyl acetate (VAc)-water ratio.
34562534	2	22	theme	vinyl	453:457	arg1	acetate					459:465	vinyl acetate	453:465	vinyl acetate (VAc)	453:471	In this work, solid-liquid controllable polymerization products could obtain by adjusting cellulose nanocrystals (CNCs) concentration and vinyl acetate (VAc)-water ratio.
34562534	1	23	theme	water	301:305	arg1	phases					307:312	water phases	301:312	water phases	301:312	Stabilities of cellulose Pickering emulsions are of great importance to utilize them effectively, but influenced by their complex compositions, such as, colloidal particles, oil phases and water phases.
34562534	5	24	theme	target	896:901	arg1	products					903:910	target products	896:910	target products	896:910	This is an innovative method that different forms of target products are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems.
34562534	1	25	theme	Pickering	137:145	arg1	emulsions					147:155	cellulose Pickering emulsions	127:155	cellulose Pickering emulsions	127:155	Stabilities of cellulose Pickering emulsions are of great importance to utilize them effectively, but influenced by their complex compositions, such as, colloidal particles, oil phases and water phases.
34562534	0	26	theme	controllable	74:85	arg1	polymerization					96:109	solid-liquid controllable emulsion polymerization	61:109	solid-liquid controllable emulsion polymerization	61:109	Cellulose nanocrystals concentration and oil-water ratio for solid-liquid controllable emulsion polymerization.
34562534	4	27	from	emulsions	606:614	arg1	zone					619:622	zone II	619:625	zone II	619:625	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	1	28	theme	complex	234:240	arg1	compositions					242:253	their complex compositions	228:253	their complex compositions	228:253	Stabilities of cellulose Pickering emulsions are of great importance to utilize them effectively, but influenced by their complex compositions, such as, colloidal particles, oil phases and water phases.
34562534	0	29	theme	oil-water	41:49	arg1	ratio					51:55	oil-water ratio	41:55	oil-water ratio	41:55	Cellulose nanocrystals concentration and oil-water ratio for solid-liquid controllable emulsion polymerization.
34562534	2	30	theme	-water	472:477	arg1	ratio					479:483	-water ratio	472:483	-water ratio	472:483	In this work, solid-liquid controllable polymerization products could obtain by adjusting cellulose nanocrystals (CNCs) concentration and vinyl acetate (VAc)-water ratio.
34562534	1	31	dep	such	256:259	arg1	as					261:262	as	261:262	as	261:262	Stabilities of cellulose Pickering emulsions are of great importance to utilize them effectively, but influenced by their complex compositions, such as, colloidal particles, oil phases and water phases.
34562534	3	32	theme	diagram	548:554	arg1	emulsions					490:498	The emulsions	486:498	The emulsions in zone Ӏ (w/o) and II (o/w) of the three-phase diagram	486:554	The emulsions in zone Ӏ (w/o) and II (o/w) of the three-phase diagram were selected for researching.
34562534	4	33	theme	large	808:812	arg1	number					814:819	a large number	806:819	a large number of porous structures	806:840	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	1	34	theme	emulsions	147:155	arg1	Stabilities					112:122	Stabilities	112:122	Stabilities of cellulose Pickering emulsions	112:155	Stabilities of cellulose Pickering emulsions are of great importance to utilize them effectively, but influenced by their complex compositions, such as, colloidal particles, oil phases and water phases.
34562534	2	35	dep	concentration	435:447	arg1	ratio					479:483	-water ratio	472:483	-water ratio	472:483	In this work, solid-liquid controllable polymerization products could obtain by adjusting cellulose nanocrystals (CNCs) concentration and vinyl acetate (VAc)-water ratio.
34562534	2	36	theme	controllable	342:353	arg1	products					370:377	solid-liquid controllable polymerization products	329:377	solid-liquid controllable polymerization products	329:377	In this work, solid-liquid controllable polymerization products could obtain by adjusting cellulose nanocrystals (CNCs) concentration and vinyl acetate (VAc)-water ratio.
34562534	4	37	from	concentration	692:704	arg1	practicality					735:746	practicality	735:746	practicality	735:746	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	4	37	from	concentration	692:704	arg1	stability					721:729	storage stability	713:729	storage stability	713:729	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	5	38	theme	application	998:1008	arg1	field					1010:1014	the application field	994:1014	the application field	994:1014	This is an innovative method that different forms of target products are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems.
34562534	4	39	theme	emulsion	767:774	arg1	practicality					735:746	practicality	735:746	practicality	735:746	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	4	39	theme	emulsion	767:774	arg1	stability					721:729	storage stability	713:729	storage stability	713:729	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	4	40	from	polymer	781:787	arg1	Ӏ					797:797	zone Ӏ	792:797	zone Ӏ	792:797	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	2	41	theme	solid-liquid	329:340	arg1	products					370:377	solid-liquid controllable polymerization products	329:377	solid-liquid controllable polymerization products	329:377	In this work, solid-liquid controllable polymerization products could obtain by adjusting cellulose nanocrystals (CNCs) concentration and vinyl acetate (VAc)-water ratio.
34562534	5	42	theme	products	903:910	arg1	forms					887:891	different forms	877:891	different forms of target products	877:910	This is an innovative method that different forms of target products are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems.
34562534	4	43	theme	polymerized	755:765	arg1	emulsion					767:774	the polymerized emulsion	751:774	the polymerized emulsion	751:774	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	1	44	theme	great	164:168	arg1	importance					170:179	great importance	164:179	great importance	164:179	Stabilities of cellulose Pickering emulsions are of great importance to utilize them effectively, but influenced by their complex compositions, such as, colloidal particles, oil phases and water phases.
34562534	5	45	theme	different	877:885	arg1	forms					887:891	different forms	877:891	different forms of target products	877:910	This is an innovative method that different forms of target products are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems.
34562534	0	46	theme	emulsion	87:94	arg1	polymerization					96:109	solid-liquid controllable emulsion polymerization	61:109	solid-liquid controllable emulsion polymerization	61:109	Cellulose nanocrystals concentration and oil-water ratio for solid-liquid controllable emulsion polymerization.
34562534	5	47	theme	diagram	961:967	arg1	guidance					937:944	the guidance	933:944	the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems	933:1068	This is an innovative method that different forms of target products are obtained through the guidance of three-phase diagram, which not only broadens the application field, but also applies to other Pickering emulsion systems.
34562534	4	48	theme	polymerization	591:604	arg1	emulsions					606:614	The polymerization emulsions	587:614	The polymerization emulsions in zone II	587:625	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34562534	0	49	theme	solid-liquid	61:72	arg1	polymerization					96:109	solid-liquid controllable emulsion polymerization	61:109	solid-liquid controllable emulsion polymerization	61:109	Cellulose nanocrystals concentration and oil-water ratio for solid-liquid controllable emulsion polymerization.
34562534	4	50	dep	illustrated	627:637	arg1	played					653:658	played	653:658	illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion	627:774	The polymerization emulsions in zone II illustrated the o/w ratio played a more important role than CNCs concentration in the storage stability and practicality of the polymerized emulsion; The polymer in zone Ӏ showed a large number of porous structures.
34799334	2	0	contain	containing	343:352	arg1	emulsions					333:341	water-based oil emulsions	317:341	water-based oil emulsions containing flaxseed oil	317:365	Four formulations of water-based oil emulsions containing flaxseed oil were prepared, homogenized, and analyzed in terms of stability and viscosity.
34799334	2	0	contain	containing	343:352	arg2	oil					363:365	flaxseed oil	354:365	flaxseed oil	354:365	Four formulations of water-based oil emulsions containing flaxseed oil were prepared, homogenized, and analyzed in terms of stability and viscosity.
34799334	9	1	theme	dried	1288:1292	arg1	oil					1303:1305	spray dried flaxseed oil	1282:1305	spray dried flaxseed oil	1282:1305	It is concluded that spray dried flaxseed oil microcapsules prepared using chitosan as coating material enhance the stability and delivery of omega-3 fatty acids.
34799334	5	2	theme	high	765:768	arg1	stability					780:788	high oxidative stability	765:788	high oxidative stability of dried powders during storage at room temperature as compared to bulk FO	765:863	Peroxide and anisidine value revealed high oxidative stability of dried powders during storage at room temperature as compared to bulk FO.
34799334	1	3	theme	polyunsaturated	247:261	arg1	acids					269:273	polyunsaturated fatty acids	247:273	polyunsaturated fatty acids	247:273	The study is aimed to characterize the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods.
34799334	5	4	theme	dried	793:797	arg1	powders					799:805	dried powders	793:805	dried powders during storage at room temperature as compared to bulk FO	793:863	Peroxide and anisidine value revealed high oxidative stability of dried powders during storage at room temperature as compared to bulk FO.
34799334	4	5	theme	total	545:549	arg1	content					560:566	total moisture content	545:566	total moisture content of spray dried microcapsules	545:595	Results revealed that total moisture content of spray dried microcapsules was in range of 3.1 ± 0.01-3.32 ± 0.04, while highest microencapsulation efficiency found for spray dried powder was 88.8 ± 1.45.
34799334	1	6	with	combination	151:161	arg1	maltodextrin					168:179	maltodextrin	168:179	maltodextrin	168:179	The study is aimed to characterize the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods.
34799334	8	7	theme	p	1190:1190	arg1	<0.05					1192:1196	p <0.05	1190:1196	p <0.05	1190:1196	Formulations with different concentration of chitosan has significant (p <0.05) impact on emulsion properties and oxidative stability values.
34799334	1	8	theme	fatty	263:267	arg1	acids					269:273	polyunsaturated fatty acids	247:273	polyunsaturated fatty acids	247:273	The study is aimed to characterize the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods.
34799334	5	9	theme	anisidine	740:748	arg1	value					750:754	anisidine value	740:754	anisidine value	740:754	Peroxide and anisidine value revealed high oxidative stability of dried powders during storage at room temperature as compared to bulk FO.
34799334	1	10	theme	acids	269:273	arg1	delivery					235:242	the delivery	231:242	the delivery of polyunsaturated fatty acids in functional foods	231:293	The study is aimed to characterize the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods.
34799334	8	11	dep	significant	1177:1187	arg1	<0.05					1192:1196	p <0.05	1190:1196	p <0.05	1190:1196	Formulations with different concentration of chitosan has significant (p <0.05) impact on emulsion properties and oxidative stability values.
34799334	9	12	theme	flaxseed	1294:1301	arg1	oil					1303:1305	spray dried flaxseed oil	1282:1305	spray dried flaxseed oil	1282:1305	It is concluded that spray dried flaxseed oil microcapsules prepared using chitosan as coating material enhance the stability and delivery of omega-3 fatty acids.
34799334	7	13	located	observed	1094:1101	arg2	days					1071:1074	30 days	1068:1074	30 days	1068:1074	Fatty acid profile was stable after 30 days and slight change observed in composition.
34799334	7	13	located	observed	1094:1101	arg1	composition					1106:1116	composition	1106:1116	composition	1106:1116	Fatty acid profile was stable after 30 days and slight change observed in composition.
34799334	1	14	theme	wall	125:128	arg1	chitosan					139:146	the wall material chitosan	121:146	the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods	121:293	The study is aimed to characterize the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods.
34799334	8	15	theme	different	1137:1145	arg1	concentration					1147:1159	different concentration	1137:1159	different concentration of chitosan	1137:1171	Formulations with different concentration of chitosan has significant (p <0.05) impact on emulsion properties and oxidative stability values.
34799334	5	16	theme	bulk	857:860	arg1	FO					862:863	bulk FO	857:863	bulk FO	857:863	Peroxide and anisidine value revealed high oxidative stability of dried powders during storage at room temperature as compared to bulk FO.
34799334	2	17	theme	stability	420:428	arg1	terms					411:415	terms	411:415	terms of stability and viscosity	411:442	Four formulations of water-based oil emulsions containing flaxseed oil were prepared, homogenized, and analyzed in terms of stability and viscosity.
34799334	8	18	theme	emulsion	1209:1216	arg1	properties					1218:1227	emulsion properties	1209:1227	emulsion properties	1209:1227	Formulations with different concentration of chitosan has significant (p <0.05) impact on emulsion properties and oxidative stability values.
34799334	3	19	theme	Resulting	445:453	arg1	emulsions					455:463	Resulting emulsions	445:463	Resulting emulsions	445:463	Resulting emulsions were spray dried and further evaluated physicochemically.
34799334	4	20	theme	3.1	613:615	arg1	±					629:629	3.1 ± 0.01-3.32 ± 0.04	613:634	3.1 ± 0.01-3.32 ± 0.04	613:634	Results revealed that total moisture content of spray dried microcapsules was in range of 3.1 ± 0.01-3.32 ± 0.04, while highest microencapsulation efficiency found for spray dried powder was 88.8 ± 1.45.
34799334	9	21	theme	spray	1282:1286	arg1	oil					1303:1305	spray dried flaxseed oil	1282:1305	spray dried flaxseed oil	1282:1305	It is concluded that spray dried flaxseed oil microcapsules prepared using chitosan as coating material enhance the stability and delivery of omega-3 fatty acids.
34799334	6	22	with	efficient	932:940	arg1	±					996:996	3.93 ± 0.13	991:1001	3.93 ± 0.13	991:1001	Among the four formulations, formulation 3 was found to be highly efficient with high encapsulation efficiency and lower PV (3.93 ± 0.13) and AV (2.93 ± 0.21) value.
34799334	6	22	with	efficient	932:940	arg1	value					1025:1029	AV (2.93 ± 0.21) value	1008:1029	AV (2.93 ± 0.21) value	1008:1029	Among the four formulations, formulation 3 was found to be highly efficient with high encapsulation efficiency and lower PV (3.93 ± 0.13) and AV (2.93 ± 0.21) value.
34799334	6	22	with	efficient	932:940	arg1	efficiency					966:975	high encapsulation efficiency	947:975	high encapsulation efficiency	947:975	Among the four formulations, formulation 3 was found to be highly efficient with high encapsulation efficiency and lower PV (3.93 ± 0.13) and AV (2.93 ± 0.21) value.
34799334	6	22	with	efficient	932:940	arg1	PV					987:988	lower PV	981:988	lower PV	981:988	Among the four formulations, formulation 3 was found to be highly efficient with high encapsulation efficiency and lower PV (3.93 ± 0.13) and AV (2.93 ± 0.21) value.
34799334	6	23	theme	AV	1008:1009	arg1	value					1025:1029	AV (2.93 ± 0.21) value	1008:1029	AV (2.93 ± 0.21) value	1008:1029	Among the four formulations, formulation 3 was found to be highly efficient with high encapsulation efficiency and lower PV (3.93 ± 0.13) and AV (2.93 ± 0.21) value.
34799334	9	24	theme	acids	1417:1421	arg1	delivery					1391:1398	delivery	1391:1398	delivery	1391:1398	It is concluded that spray dried flaxseed oil microcapsules prepared using chitosan as coating material enhance the stability and delivery of omega-3 fatty acids.
34799334	9	24	theme	acids	1417:1421	arg1	stability					1377:1385	stability	1377:1385	stability	1377:1385	It is concluded that spray dried flaxseed oil microcapsules prepared using chitosan as coating material enhance the stability and delivery of omega-3 fatty acids.
34799334	5	25	theme	room	825:828	arg1	temperature					830:840	room temperature as compared to bulk FO	825:863	room temperature as compared to bulk FO	825:863	Peroxide and anisidine value revealed high oxidative stability of dried powders during storage at room temperature as compared to bulk FO.
34799334	5	26	from	temperature	830:840	arg1	storage					814:820	storage	814:820	storage at room temperature as compared to bulk FO	814:863	Peroxide and anisidine value revealed high oxidative stability of dried powders during storage at room temperature as compared to bulk FO.
34799334	4	27	theme	microcapsules	583:595	arg1	content					560:566	total moisture content	545:566	total moisture content of spray dried microcapsules	545:595	Results revealed that total moisture content of spray dried microcapsules was in range of 3.1 ± 0.01-3.32 ± 0.04, while highest microencapsulation efficiency found for spray dried powder was 88.8 ± 1.45.
34799334	2	28	theme	oil	329:331	arg1	emulsions					333:341	water-based oil emulsions	317:341	water-based oil emulsions containing flaxseed oil	317:365	Four formulations of water-based oil emulsions containing flaxseed oil were prepared, homogenized, and analyzed in terms of stability and viscosity.
34799334	4	29	theme	dried	697:701	arg1	powder					703:708	spray dried powder	691:708	spray dried powder	691:708	Results revealed that total moisture content of spray dried microcapsules was in range of 3.1 ± 0.01-3.32 ± 0.04, while highest microencapsulation efficiency found for spray dried powder was 88.8 ± 1.45.
34799334	1	30	theme	functional	278:287	arg1	foods					289:293	functional foods	278:293	functional foods	278:293	The study is aimed to characterize the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods.
34799334	8	31	with	Formulations	1119:1130	arg1	concentration					1147:1159	different concentration	1137:1159	different concentration of chitosan	1137:1171	Formulations with different concentration of chitosan has significant (p <0.05) impact on emulsion properties and oxidative stability values.
34799334	2	32	theme	water-based	317:327	arg1	emulsions					333:341	water-based oil emulsions	317:341	water-based oil emulsions containing flaxseed oil	317:365	Four formulations of water-based oil emulsions containing flaxseed oil were prepared, homogenized, and analyzed in terms of stability and viscosity.
34799334	4	33	theme	spray	691:695	arg1	powder					703:708	spray dried powder	691:708	spray dried powder	691:708	Results revealed that total moisture content of spray dried microcapsules was in range of 3.1 ± 0.01-3.32 ± 0.04, while highest microencapsulation efficiency found for spray dried powder was 88.8 ± 1.45.
34799334	4	34	theme	dried	577:581	arg1	microcapsules					583:595	spray dried microcapsules	571:595	spray dried microcapsules	571:595	Results revealed that total moisture content of spray dried microcapsules was in range of 3.1 ± 0.01-3.32 ± 0.04, while highest microencapsulation efficiency found for spray dried powder was 88.8 ± 1.45.
34799334	7	35	theme	Fatty	1032:1036	arg1	profile					1043:1049	Fatty acid profile	1032:1049	Fatty acid profile	1032:1049	Fatty acid profile was stable after 30 days and slight change observed in composition.
34799334	1	36	from	chitosan	139:146	arg1	combination					151:161	combination	151:161	combination with maltodextrin	151:179	The study is aimed to characterize the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods.
34799334	4	37	theme	highest	643:649	arg1	efficiency					670:679	highest microencapsulation efficiency	643:679	highest microencapsulation efficiency found for spray dried powder	643:708	Results revealed that total moisture content of spray dried microcapsules was in range of 3.1 ± 0.01-3.32 ± 0.04, while highest microencapsulation efficiency found for spray dried powder was 88.8 ± 1.45.
34799334	2	38	theme	viscosity	434:442	arg1	terms					411:415	terms	411:415	terms of stability and viscosity	411:442	Four formulations of water-based oil emulsions containing flaxseed oil were prepared, homogenized, and analyzed in terms of stability and viscosity.
34799334	7	39	theme	acid	1038:1041	arg1	profile					1043:1049	Fatty acid profile	1032:1049	Fatty acid profile	1032:1049	Fatty acid profile was stable after 30 days and slight change observed in composition.
34799334	1	40	theme	flaxseed	207:214	arg1	oil					216:218	flaxseed oil	207:218	flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods	207:293	The study is aimed to characterize the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods.
34799334	5	41	theme	powders	799:805	arg1	stability					780:788	high oxidative stability	765:788	high oxidative stability of dried powders during storage at room temperature as compared to bulk FO	765:863	Peroxide and anisidine value revealed high oxidative stability of dried powders during storage at room temperature as compared to bulk FO.
34799334	8	42	theme	stability	1243:1251	arg1	values					1253:1258	oxidative stability values	1233:1258	oxidative stability values	1233:1258	Formulations with different concentration of chitosan has significant (p <0.05) impact on emulsion properties and oxidative stability values.
34799334	8	43	theme	chitosan	1164:1171	arg1	concentration					1147:1159	different concentration	1137:1159	different concentration of chitosan	1137:1171	Formulations with different concentration of chitosan has significant (p <0.05) impact on emulsion properties and oxidative stability values.
34799334	1	44	theme	oil	216:218	arg1	microencapsulation					185:202	microencapsulation	185:202	microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods	185:293	The study is aimed to characterize the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods.
34799334	5	45	theme	oxidative	770:778	arg1	stability					780:788	high oxidative stability	765:788	high oxidative stability of dried powders during storage at room temperature as compared to bulk FO	765:863	Peroxide and anisidine value revealed high oxidative stability of dried powders during storage at room temperature as compared to bulk FO.
34799334	6	46	theme	encapsulation	952:964	arg1	±					996:996	3.93 ± 0.13	991:1001	3.93 ± 0.13	991:1001	Among the four formulations, formulation 3 was found to be highly efficient with high encapsulation efficiency and lower PV (3.93 ± 0.13) and AV (2.93 ± 0.21) value.
34799334	6	46	theme	encapsulation	952:964	arg1	efficiency					966:975	high encapsulation efficiency	947:975	high encapsulation efficiency	947:975	Among the four formulations, formulation 3 was found to be highly efficient with high encapsulation efficiency and lower PV (3.93 ± 0.13) and AV (2.93 ± 0.21) value.
34799334	8	47	theme	significant	1177:1187	arg1	impact					1199:1204	significant (p <0.05) impact	1177:1204	significant (p <0.05) impact on emulsion properties and oxidative stability values	1177:1258	Formulations with different concentration of chitosan has significant (p <0.05) impact on emulsion properties and oxidative stability values.
34799334	9	48	dep	material	1356:1363	arg1	enhance					1365:1371	enhance	1365:1371	enhance the stability and delivery of omega-3 fatty acids	1365:1421	It is concluded that spray dried flaxseed oil microcapsules prepared using chitosan as coating material enhance the stability and delivery of omega-3 fatty acids.
34799334	4	49	theme	microencapsulation	651:668	arg1	efficiency					670:679	highest microencapsulation efficiency	643:679	highest microencapsulation efficiency found for spray dried powder	643:708	Results revealed that total moisture content of spray dried microcapsules was in range of 3.1 ± 0.01-3.32 ± 0.04, while highest microencapsulation efficiency found for spray dried powder was 88.8 ± 1.45.
34799334	0	50	theme	oil	60:62	arg1	microencapsulation					29:46	microencapsulation	29:46	microencapsulation of flaxseed oil through spray drying	29:83	Optimization of chitosan for microencapsulation of flaxseed oil through spray drying.
34799334	4	51	theme	moisture	551:558	arg1	content					560:566	total moisture content	545:566	total moisture content of spray dried microcapsules	545:595	Results revealed that total moisture content of spray dried microcapsules was in range of 3.1 ± 0.01-3.32 ± 0.04, while highest microencapsulation efficiency found for spray dried powder was 88.8 ± 1.45.
34799334	1	52	from	delivery	235:242	arg1	foods					289:293	functional foods	278:293	functional foods	278:293	The study is aimed to characterize the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods.
34799334	6	53	theme	lower	981:985	arg1	PV					987:988	lower PV	981:988	lower PV	981:988	Among the four formulations, formulation 3 was found to be highly efficient with high encapsulation efficiency and lower PV (3.93 ± 0.13) and AV (2.93 ± 0.21) value.
34799334	9	54	theme	fatty	1411:1415	arg1	acids					1417:1421	omega-3 fatty acids	1403:1421	omega-3 fatty acids	1403:1421	It is concluded that spray dried flaxseed oil microcapsules prepared using chitosan as coating material enhance the stability and delivery of omega-3 fatty acids.
34799334	0	55	theme	flaxseed	51:58	arg1	oil					60:62	flaxseed oil	51:62	flaxseed oil	51:62	Optimization of chitosan for microencapsulation of flaxseed oil through spray drying.
34799334	4	56	theme	spray	571:575	arg1	microcapsules					583:595	spray dried microcapsules	571:595	spray dried microcapsules	571:595	Results revealed that total moisture content of spray dried microcapsules was in range of 3.1 ± 0.01-3.32 ± 0.04, while highest microencapsulation efficiency found for spray dried powder was 88.8 ± 1.45.
34799334	7	57	theme	slight	1080:1085	arg1	change					1087:1092	slight change	1080:1092	slight change	1080:1092	Fatty acid profile was stable after 30 days and slight change observed in composition.
34799334	8	58	from	impact	1199:1204	arg1	values					1253:1258	oxidative stability values	1233:1258	oxidative stability values	1233:1258	Formulations with different concentration of chitosan has significant (p <0.05) impact on emulsion properties and oxidative stability values.
34799334	8	58	from	impact	1199:1204	arg1	properties					1218:1227	emulsion properties	1209:1227	emulsion properties	1209:1227	Formulations with different concentration of chitosan has significant (p <0.05) impact on emulsion properties and oxidative stability values.
34799334	2	59	theme	flaxseed	354:361	arg1	oil					363:365	flaxseed oil	354:365	flaxseed oil	354:365	Four formulations of water-based oil emulsions containing flaxseed oil were prepared, homogenized, and analyzed in terms of stability and viscosity.
34799334	4	60	theme	±	629:629	arg1	range					604:608	range	604:608	range of 3.1 ± 0.01-3.32 ± 0.04	604:634	Results revealed that total moisture content of spray dried microcapsules was in range of 3.1 ± 0.01-3.32 ± 0.04, while highest microencapsulation efficiency found for spray dried powder was 88.8 ± 1.45.
34799334	8	61	contain	has	1173:1175	arg1	Formulations					1119:1130	Formulations	1119:1130	Formulations with different concentration of chitosan	1119:1171	Formulations with different concentration of chitosan has significant (p <0.05) impact on emulsion properties and oxidative stability values.
34799334	8	61	contain	has	1173:1175	arg2	impact					1199:1204	significant (p <0.05) impact	1177:1204	significant (p <0.05) impact on emulsion properties and oxidative stability values	1177:1258	Formulations with different concentration of chitosan has significant (p <0.05) impact on emulsion properties and oxidative stability values.
34799334	2	62	theme	emulsions	333:341	arg1	formulations					301:312	Four formulations	296:312	Four formulations of water-based oil emulsions containing flaxseed oil	296:365	Four formulations of water-based oil emulsions containing flaxseed oil were prepared, homogenized, and analyzed in terms of stability and viscosity.
34799334	4	63	theme	0.01-3.32	619:627	arg1	±					629:629	3.1 ± 0.01-3.32 ± 0.04	613:634	3.1 ± 0.01-3.32 ± 0.04	613:634	Results revealed that total moisture content of spray dried microcapsules was in range of 3.1 ± 0.01-3.32 ± 0.04, while highest microencapsulation efficiency found for spray dried powder was 88.8 ± 1.45.
34799334	0	64	theme	spray	72:76	arg1	drying					78:83	spray drying	72:83	spray drying	72:83	Optimization of chitosan for microencapsulation of flaxseed oil through spray drying.
34799334	8	65	theme	oxidative	1233:1241	arg1	values					1253:1258	oxidative stability values	1233:1258	oxidative stability values	1233:1258	Formulations with different concentration of chitosan has significant (p <0.05) impact on emulsion properties and oxidative stability values.
34799334	1	66	theme	material	130:137	arg1	chitosan					139:146	the wall material chitosan	121:146	the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods	121:293	The study is aimed to characterize the wall material chitosan in combination with maltodextrin for microencapsulation of flaxseed oil to enhance the delivery of polyunsaturated fatty acids in functional foods.
34799334	4	67	theme	±	617:617	arg1	±					629:629	3.1 ± 0.01-3.32 ± 0.04	613:634	3.1 ± 0.01-3.32 ± 0.04	613:634	Results revealed that total moisture content of spray dried microcapsules was in range of 3.1 ± 0.01-3.32 ± 0.04, while highest microencapsulation efficiency found for spray dried powder was 88.8 ± 1.45.
34799334	9	68	dep	microcapsules	1307:1319	arg1	prepared					1321:1328	prepared	1321:1328	microcapsules prepared using chitosan as coating material enhance the stability and delivery of omega-3 fatty acids	1307:1421	It is concluded that spray dried flaxseed oil microcapsules prepared using chitosan as coating material enhance the stability and delivery of omega-3 fatty acids.
34799334	0	69	theme	chitosan	16:23	arg1	Optimization					0:11	Optimization	0:11	Optimization of chitosan for microencapsulation of flaxseed oil through spray drying.	0:84	Optimization of chitosan for microencapsulation of flaxseed oil through spray drying.
34799334	9	70	dep	stability	1377:1385	arg1	the					1373:1375	the	1373:1375	the	1373:1375	It is concluded that spray dried flaxseed oil microcapsules prepared using chitosan as coating material enhance the stability and delivery of omega-3 fatty acids.
34799334	6	71	theme	high	947:950	arg1	±					996:996	3.93 ± 0.13	991:1001	3.93 ± 0.13	991:1001	Among the four formulations, formulation 3 was found to be highly efficient with high encapsulation efficiency and lower PV (3.93 ± 0.13) and AV (2.93 ± 0.21) value.
34799334	6	71	theme	high	947:950	arg1	efficiency					966:975	high encapsulation efficiency	947:975	high encapsulation efficiency	947:975	Among the four formulations, formulation 3 was found to be highly efficient with high encapsulation efficiency and lower PV (3.93 ± 0.13) and AV (2.93 ± 0.21) value.
32935859	5	0	theme	gain	613:616	arg1	dynamics					582:589	the mass transfer dynamics	564:589	the mass transfer dynamics of simultaneous water gain and solid loss taking place during soaking	564:659	In the present investigation, the mass transfer dynamics of simultaneous water gain and solid loss taking place during soaking was studied .
32935859	11	1	theme	third	1373:1377	arg1	stage					1379:1383	the third stage	1369:1383	the third stage	1369:1383	The second stage was marked at 5% of solid loss and characterized by solid loss, while the third stage contributed to the starch gelatinization process.
32935859	7	2	theme	9.48	1004:1007	arg1	m²/s					1017:1020	9.48 × 10-10 m²/s	1004:1020	9.48 × 10-10 m²/s	1004:1020	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	17	3	theme	wastage	2197:2203	arg1	retention					2156:2164	maximum retention	2148:2164	maximum retention of quality attributes, minimum wastage, and low-energy consumption	2148:2231	Also the representation of these behaviors in mathematical models is essential to further understand and optimize the operations for maximum retention of quality attributes, minimum wastage, and low-energy consumption.
32935859	5	4	theme	solid	622:626	arg1	loss					628:631	solid loss	622:631	solid loss	622:631	In the present investigation, the mass transfer dynamics of simultaneous water gain and solid loss taking place during soaking was studied .
32935859	2	5	theme	food	249:252	arg1	processing					254:263	food processing	249:263	food processing	249:263	This is one of the leading pulse utilized in various applications in food processing.
32935859	8	6	theme	activation	1037:1046	arg1	energies					1048:1055	The activation energies	1033:1055	The activation energies of both the phenomenon	1033:1078	The activation energies of both the phenomenon were estimated using the Arrhenius equation.
32935859	8	7	theme	Arrhenius	1105:1113	arg1	equation					1115:1122	the Arrhenius equation	1101:1122	the Arrhenius equation	1101:1122	The activation energies of both the phenomenon were estimated using the Arrhenius equation.
32935859	13	8	theme	pigeon	1622:1627	arg1	behavior					1641:1648	pigeon pea soaking behavior	1622:1648	pigeon pea soaking behavior	1622:1648	The insights into mass transfers from this study can help in further modeling of pigeon pea soaking behavior.
32935859	16	9	dep	chemical	1910:1917	arg1	physical					1920:1927	physical	1920:1927	physical	1920:1927	Pigeon pea being a leading legume, understanding of the dynamics of various chemical, physical, and compositional changes during soaking is very much required for a process design.
32935859	14	10	theme	legume	1738:1743	arg1	grains					1745:1750	legume grains	1738:1750	legume grains	1738:1750	PRACTICAL APPLICATION: Soaking is one of the mandatory step for further utilization of legume grains.
32935859	5	11	theme	simultaneous	594:605	arg1	gain					613:616	simultaneous water gain	594:616	simultaneous water gain	594:616	In the present investigation, the mass transfer dynamics of simultaneous water gain and solid loss taking place during soaking was studied .
32935859	1	12	theme	human	161:165	arg1	consumption					167:177	human consumption	161:177	human consumption	161:177	Pigeon pea is the most prominently used protein source for human consumption.
32935859	12	13	theme	water	1448:1452	arg1	gain					1454:1457	Simultaneous water gain	1435:1457	Simultaneous water gain	1435:1457	Simultaneous water gain and solid loss in the grain was observed throughout the process at varying rates.
32935859	7	14	theme	6.27	978:981	arg1	×					983:983	×	983:983	×	983:983	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	4	15	theme	transfer	390:397	arg1	dynamics					399:406	its mass transfer dynamics	381:406	its mass transfer dynamics	381:406	Insights into its mass transfer dynamics enable the design and optimization of processing conditions with due consideration of retention of its quality and nutrition.
32935859	14	16	theme	mandatory	1696:1704	arg1	step					1706:1709	the mandatory step	1692:1709	the mandatory step for further utilization of legume grains	1692:1750	PRACTICAL APPLICATION: Soaking is one of the mandatory step for further utilization of legume grains.
32935859	7	17	theme	×	1009:1009	arg1	m²/s					1017:1020	9.48 × 10-10 m²/s	1004:1020	9.48 × 10-10 m²/s	1004:1020	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	7	18	theme	solid	945:949	arg1	diffusivities					951:963	solid diffusivities	945:963	solid diffusivities	945:963	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	1	19	theme	Pigeon	102:107	arg1	pea					109:111	Pigeon pea	102:111	Pigeon pea	102:111	Pigeon pea is the most prominently used protein source for human consumption.
32935859	1	19	theme	Pigeon	102:107	arg1	source					150:155	the most prominently used protein source	116:155	the most prominently used protein source for human consumption	116:177	Pigeon pea is the most prominently used protein source for human consumption.
32935859	14	20	theme	grains	1745:1750	arg1	utilization					1723:1733	further utilization	1715:1733	further utilization of legume grains	1715:1750	PRACTICAL APPLICATION: Soaking is one of the mandatory step for further utilization of legume grains.
32935859	9	21	theme	transfer	1134:1141	arg1	process					1143:1149	The mass transfer process	1125:1149	The mass transfer process	1125:1149	The mass transfer process has been identified with three distinct stages.
32935859	3	22	theme	mandatory	288:296	arg1	operation					303:311	the mandatory unit operation	284:311	the mandatory unit operation required to convert it from raw to a consumable form	284:364	Soaking is one of the mandatory unit operation required to convert it from raw to a consumable form.
32935859	17	23	theme	maximum	2148:2154	arg1	retention					2156:2164	maximum retention	2148:2164	maximum retention of quality attributes, minimum wastage, and low-energy consumption	2148:2231	Also the representation of these behaviors in mathematical models is essential to further understand and optimize the operations for maximum retention of quality attributes, minimum wastage, and low-energy consumption.
32935859	11	24	theme	loss	1325:1328	arg1	%					1314:1314	5%	1313:1314	5% of solid loss	1313:1328	The second stage was marked at 5% of solid loss and characterized by solid loss, while the third stage contributed to the starch gelatinization process.
32935859	11	24	theme	loss	1325:1328	arg1	loss					1325:1328	solid loss	1319:1328	solid loss	1319:1328	The second stage was marked at 5% of solid loss and characterized by solid loss, while the third stage contributed to the starch gelatinization process.
32935859	0	25	theme	solid	54:58	arg1	loss					60:63	solid loss	54:63	solid loss	54:63	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.
32935859	2	26	theme	pulse	207:211	arg1	one					188:190	one	188:190	one	188:190	This is one of the leading pulse utilized in various applications in food processing.
32935859	2	26	theme	pulse	207:211	arg1	pulse					207:211	the leading pulse	195:211	the leading pulse utilized in various applications in food processing	195:263	This is one of the leading pulse utilized in various applications in food processing.
32935859	7	27	theme	soaking	881:887	arg1	temperature					889:899	soaking temperature	881:899	soaking temperature	881:899	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	4	28	theme	processing	446:455	arg1	conditions					457:466	processing conditions	446:466	processing conditions	446:466	Insights into its mass transfer dynamics enable the design and optimization of processing conditions with due consideration of retention of its quality and nutrition.
32935859	7	29	theme	m²/s	871:874	arg1	×					863:863	10-10 to 13.84 ×	848:863	5.492 × 10-10 to 13.84 × 10-10 m²/s	840:874	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	1	30	theme	used	137:140	arg1	pea					109:111	Pigeon pea	102:111	Pigeon pea	102:111	Pigeon pea is the most prominently used protein source for human consumption.
32935859	1	30	theme	used	137:140	arg1	source					150:155	the most prominently used protein source	116:155	the most prominently used protein source for human consumption	116:177	Pigeon pea is the most prominently used protein source for human consumption.
32935859	17	31	theme	mathematical	2061:2072	arg1	models					2074:2079	mathematical models	2061:2079	mathematical models	2061:2079	Also the representation of these behaviors in mathematical models is essential to further understand and optimize the operations for maximum retention of quality attributes, minimum wastage, and low-energy consumption.
32935859	15	32	theme	undesirable	1775:1785	arg1	changes					1787:1793	Various desirable and undesirable changes	1753:1793	Various desirable and undesirable changes	1753:1793	Various desirable and undesirable changes take place during the soaking process.
32935859	7	33	dep	13.84	857:861	arg1	to					854:855	to	854:855	to	854:855	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	3	34	theme	operation	303:311	arg1	operation					303:311	the mandatory unit operation	284:311	the mandatory unit operation required to convert it from raw to a consumable form	284:364	Soaking is one of the mandatory unit operation required to convert it from raw to a consumable form.
32935859	3	34	theme	operation	303:311	arg1	one					277:279	one	277:279	one	277:279	Soaking is one of the mandatory unit operation required to convert it from raw to a consumable form.
32935859	15	35	theme	desirable	1761:1769	arg1	changes					1787:1793	Various desirable and undesirable changes	1753:1793	Various desirable and undesirable changes	1753:1793	Various desirable and undesirable changes take place during the soaking process.
32935859	0	36	theme	pea	90:92	arg1	grains					94:99	pigeon pea grains	83:99	pigeon pea grains	83:99	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.
32935859	13	37	from	study	1584:1588	arg1	transfers					1564:1572	mass transfers	1559:1572	mass transfers from this study	1559:1588	The insights into mass transfers from this study can help in further modeling of pigeon pea soaking behavior.
32935859	16	38	theme	compositional	1934:1946	arg1	changes					1948:1954	compositional changes	1934:1954	compositional changes during soaking	1934:1969	Pigeon pea being a leading legume, understanding of the dynamics of various chemical, physical, and compositional changes during soaking is very much required for a process design.
32935859	7	39	dep	100	926:928	arg1	to					923:924	to	923:924	to	923:924	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	0	40	theme	Mass	0:3	arg1	dynamics					14:21	Mass transfer dynamics	0:21	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.	0:100	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.
32935859	17	41	theme	consumption	2221:2231	arg1	retention					2156:2164	maximum retention	2148:2164	maximum retention of quality attributes, minimum wastage, and low-energy consumption	2148:2231	Also the representation of these behaviors in mathematical models is essential to further understand and optimize the operations for maximum retention of quality attributes, minimum wastage, and low-energy consumption.
32935859	17	42	theme	low-energy	2210:2219	arg1	consumption					2221:2231	low-energy consumption	2210:2231	low-energy consumption	2210:2231	Also the representation of these behaviors in mathematical models is essential to further understand and optimize the operations for maximum retention of quality attributes, minimum wastage, and low-energy consumption.
32935859	16	43	theme	leading	1853:1859	arg1	legume					1861:1866	a leading legume	1851:1866	a leading legume	1851:1866	Pigeon pea being a leading legume, understanding of the dynamics of various chemical, physical, and compositional changes during soaking is very much required for a process design.
32935859	6	44	theme	gelatinization	775:788	arg1	temperatures					790:801	the lower and upper gelatinization temperatures	755:801	the lower and upper gelatinization temperatures	755:801	The experimental samples were soaked at 35, 50, 75, 85, and 100 °C to represent the lower and upper gelatinization temperatures.
32935859	0	45	theme	simultaneous	26:37	arg1	gain					45:48	simultaneous water gain	26:48	simultaneous water gain	26:48	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.
32935859	15	46	theme	soaking	1817:1823	arg1	process					1825:1831	the soaking process	1813:1831	the soaking process	1813:1831	Various desirable and undesirable changes take place during the soaking process.
32935859	14	47	dep	APPLICATION	1661:1671	arg1	Soaking					1674:1680	Soaking	1674:1680	PRACTICAL APPLICATION: Soaking	1651:1680	PRACTICAL APPLICATION: Soaking is one of the mandatory step for further utilization of legume grains.
32935859	0	48	theme	gain	45:48	arg1	dynamics					14:21	Mass transfer dynamics	0:21	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.	0:100	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.
32935859	4	49	theme	retention	494:502	arg1	consideration					477:489	due consideration	473:489	due consideration of retention of its quality and nutrition	473:531	Insights into its mass transfer dynamics enable the design and optimization of processing conditions with due consideration of retention of its quality and nutrition.
32935859	16	50	theme	dynamics	1890:1897	arg1	legume					1861:1866	a leading legume	1851:1866	a leading legume	1851:1866	Pigeon pea being a leading legume, understanding of the dynamics of various chemical, physical, and compositional changes during soaking is very much required for a process design.
32935859	16	50	theme	dynamics	1890:1897	arg1	changes					1948:1954	compositional changes	1934:1954	compositional changes during soaking	1934:1969	Pigeon pea being a leading legume, understanding of the dynamics of various chemical, physical, and compositional changes during soaking is very much required for a process design.
32935859	16	50	theme	dynamics	1890:1897	arg1	understanding					1869:1881	understanding	1869:1881	understanding of the dynamics of various chemical, physical	1869:1927	Pigeon pea being a leading legume, understanding of the dynamics of various chemical, physical, and compositional changes during soaking is very much required for a process design.
32935859	13	51	theme	pea	1629:1631	arg1	behavior					1641:1648	pigeon pea soaking behavior	1622:1648	pigeon pea soaking behavior	1622:1648	The insights into mass transfers from this study can help in further modeling of pigeon pea soaking behavior.
32935859	10	52	theme	void	1236:1239	arg1	filling					1241:1247	void filling	1236:1247	void filling	1236:1247	The first stage was characterized by void filling, expansion, and solid hydration.
32935859	17	53	theme	attributes	2177:2186	arg1	retention					2156:2164	maximum retention	2148:2164	maximum retention of quality attributes, minimum wastage, and low-energy consumption	2148:2231	Also the representation of these behaviors in mathematical models is essential to further understand and optimize the operations for maximum retention of quality attributes, minimum wastage, and low-energy consumption.
32935859	13	54	theme	behavior	1641:1648	arg1	modeling					1610:1617	further modeling	1602:1617	further modeling of pigeon pea soaking behavior	1602:1648	The insights into mass transfers from this study can help in further modeling of pigeon pea soaking behavior.
32935859	5	55	theme	water	607:611	arg1	gain					613:616	simultaneous water gain	594:616	simultaneous water gain	594:616	In the present investigation, the mass transfer dynamics of simultaneous water gain and solid loss taking place during soaking was studied .
32935859	7	56	theme	water	808:812	arg1	diffusivities					814:826	The water diffusivities	804:826	The water diffusivities	804:826	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	12	57	located	observed	1491:1498	arg2	loss					1469:1472	solid loss	1463:1472	solid loss	1463:1472	Simultaneous water gain and solid loss in the grain was observed throughout the process at varying rates.
32935859	12	57	located	observed	1491:1498	arg2	gain					1454:1457	Simultaneous water gain	1435:1457	Simultaneous water gain	1435:1457	Simultaneous water gain and solid loss in the grain was observed throughout the process at varying rates.
32935859	12	57	located	observed	1491:1498	arg1	rates					1534:1538	varying rates	1526:1538	varying rates	1526:1538	Simultaneous water gain and solid loss in the grain was observed throughout the process at varying rates.
32935859	17	58	theme	minimum	2189:2195	arg1	wastage					2197:2203	minimum wastage	2189:2203	minimum wastage	2189:2203	Also the representation of these behaviors in mathematical models is essential to further understand and optimize the operations for maximum retention of quality attributes, minimum wastage, and low-energy consumption.
32935859	13	59	theme	further	1602:1608	arg1	modeling					1610:1617	further modeling	1602:1617	further modeling of pigeon pea soaking behavior	1602:1648	The insights into mass transfers from this study can help in further modeling of pigeon pea soaking behavior.
32935859	5	60	theme	transfer	573:580	arg1	dynamics					582:589	the mass transfer dynamics	564:589	the mass transfer dynamics of simultaneous water gain and solid loss taking place during soaking	564:659	In the present investigation, the mass transfer dynamics of simultaneous water gain and solid loss taking place during soaking was studied .
32935859	1	61	theme	protein	142:148	arg1	pea					109:111	Pigeon pea	102:111	Pigeon pea	102:111	Pigeon pea is the most prominently used protein source for human consumption.
32935859	1	61	theme	protein	142:148	arg1	source					150:155	the most prominently used protein source	116:155	the most prominently used protein source for human consumption	116:177	Pigeon pea is the most prominently used protein source for human consumption.
32935859	7	62	theme	×	983:983	arg1	°C					997:998	10-10 at 35 °C	985:998	10-10 at 35 °C	985:998	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	11	63	theme	starch	1404:1409	arg1	process					1426:1432	the starch gelatinization process	1400:1432	the starch gelatinization process	1400:1432	The second stage was marked at 5% of solid loss and characterized by solid loss, while the third stage contributed to the starch gelatinization process.
32935859	10	64	theme	solid	1265:1269	arg1	hydration					1271:1279	solid hydration	1265:1279	solid hydration	1265:1279	The first stage was characterized by void filling, expansion, and solid hydration.
32935859	14	65	theme	further	1715:1721	arg1	utilization					1723:1733	further utilization	1715:1733	further utilization of legume grains	1715:1750	PRACTICAL APPLICATION: Soaking is one of the mandatory step for further utilization of legume grains.
32935859	12	66	theme	solid	1463:1467	arg1	loss					1469:1472	solid loss	1463:1472	solid loss	1463:1472	Simultaneous water gain and solid loss in the grain was observed throughout the process at varying rates.
32935859	11	67	theme	gelatinization	1411:1424	arg1	process					1426:1432	the starch gelatinization process	1400:1432	the starch gelatinization process	1400:1432	The second stage was marked at 5% of solid loss and characterized by solid loss, while the third stage contributed to the starch gelatinization process.
32935859	12	68	from	loss	1469:1472	arg1	grain					1481:1485	the grain	1477:1485	the grain	1477:1485	Simultaneous water gain and solid loss in the grain was observed throughout the process at varying rates.
32935859	7	69	theme	10-10	865:869	arg1	m²/s					871:874	m²/s	871:874	m²/s	871:874	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	13	70	theme	mass	1559:1562	arg1	transfers					1564:1572	mass transfers	1559:1572	mass transfers from this study	1559:1588	The insights into mass transfers from this study can help in further modeling of pigeon pea soaking behavior.
32935859	17	71	theme	behaviors	2048:2056	arg1	essential					2084:2092	essential	2084:2092	essential	2084:2092	Also the representation of these behaviors in mathematical models is essential to further understand and optimize the operations for maximum retention of quality attributes, minimum wastage, and low-energy consumption.
32935859	17	71	theme	behaviors	2048:2056	arg1	representation					2024:2037	the representation	2020:2037	the representation of these behaviors in mathematical models	2020:2079	Also the representation of these behaviors in mathematical models is essential to further understand and optimize the operations for maximum retention of quality attributes, minimum wastage, and low-energy consumption.
32935859	2	72	theme	leading	199:205	arg1	pulse					207:211	the leading pulse	195:211	the leading pulse utilized in various applications in food processing	195:263	This is one of the leading pulse utilized in various applications in food processing.
32935859	14	73	theme	step	1706:1709	arg1	one					1685:1687	one	1685:1687	one	1685:1687	PRACTICAL APPLICATION: Soaking is one of the mandatory step for further utilization of legume grains.
32935859	14	73	theme	step	1706:1709	arg1	step					1706:1709	the mandatory step	1692:1709	the mandatory step for further utilization of legume grains	1692:1750	PRACTICAL APPLICATION: Soaking is one of the mandatory step for further utilization of legume grains.
32935859	8	74	theme	phenomenon	1069:1078	arg1	energies					1048:1055	The activation energies	1033:1055	The activation energies of both the phenomenon	1033:1078	The activation energies of both the phenomenon were estimated using the Arrhenius equation.
32935859	5	75	theme	loss	628:631	arg1	dynamics					582:589	the mass transfer dynamics	564:589	the mass transfer dynamics of simultaneous water gain and solid loss taking place during soaking	564:659	In the present investigation, the mass transfer dynamics of simultaneous water gain and solid loss taking place during soaking was studied .
32935859	12	76	theme	Simultaneous	1435:1446	arg1	gain					1454:1457	Simultaneous water gain	1435:1457	Simultaneous water gain	1435:1457	Simultaneous water gain and solid loss in the grain was observed throughout the process at varying rates.
32935859	17	77	from	representation	2024:2037	arg1	models					2074:2079	mathematical models	2061:2079	mathematical models	2061:2079	Also the representation of these behaviors in mathematical models is essential to further understand and optimize the operations for maximum retention of quality attributes, minimum wastage, and low-energy consumption.
32935859	9	78	theme	mass	1129:1132	arg1	process					1143:1149	The mass transfer process	1125:1149	The mass transfer process	1125:1149	The mass transfer process has been identified with three distinct stages.
32935859	2	79	theme	various	225:231	arg1	applications					233:244	various applications	225:244	various applications in food processing	225:263	This is one of the leading pulse utilized in various applications in food processing.
32935859	2	80	from	applications	233:244	arg1	processing					254:263	food processing	249:263	food processing	249:263	This is one of the leading pulse utilized in various applications in food processing.
32935859	4	81	theme	mass	385:388	arg1	dynamics					399:406	its mass transfer dynamics	381:406	its mass transfer dynamics	381:406	Insights into its mass transfer dynamics enable the design and optimization of processing conditions with due consideration of retention of its quality and nutrition.
32935859	11	82	theme	solid	1319:1323	arg1	loss					1325:1328	solid loss	1319:1328	solid loss	1319:1328	The second stage was marked at 5% of solid loss and characterized by solid loss, while the third stage contributed to the starch gelatinization process.
32935859	0	83	theme	loss	60:63	arg1	dynamics					14:21	Mass transfer dynamics	0:21	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.	0:100	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.
32935859	11	84	theme	solid	1351:1355	arg1	loss					1357:1360	solid loss	1351:1360	solid loss	1351:1360	The second stage was marked at 5% of solid loss and characterized by solid loss, while the third stage contributed to the starch gelatinization process.
32935859	14	85	theme	PRACTICAL	1651:1659	arg1	APPLICATION					1661:1671	PRACTICAL APPLICATION	1651:1671	PRACTICAL APPLICATION: Soaking	1651:1680	PRACTICAL APPLICATION: Soaking is one of the mandatory step for further utilization of legume grains.
32935859	3	86	theme	unit	298:301	arg1	operation					303:311	the mandatory unit operation	284:311	the mandatory unit operation required to convert it from raw to a consumable form	284:364	Soaking is one of the mandatory unit operation required to convert it from raw to a consumable form.
32935859	4	87	theme	conditions	457:466	arg1	optimization					430:441	optimization	430:441	optimization	430:441	Insights into its mass transfer dynamics enable the design and optimization of processing conditions with due consideration of retention of its quality and nutrition.
32935859	4	87	theme	conditions	457:466	arg1	design					419:424	design	419:424	design	419:424	Insights into its mass transfer dynamics enable the design and optimization of processing conditions with due consideration of retention of its quality and nutrition.
32935859	7	88	dep	×	846:846	arg1	×					863:863	10-10 to 13.84 ×	848:863	5.492 × 10-10 to 13.84 × 10-10 m²/s	840:874	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	4	89	theme	due	473:475	arg1	consideration					477:489	due consideration	473:489	due consideration of retention of its quality and nutrition	473:531	Insights into its mass transfer dynamics enable the design and optimization of processing conditions with due consideration of retention of its quality and nutrition.
32935859	0	90	theme	pigeon	83:88	arg1	grains					94:99	pigeon pea grains	83:99	pigeon pea grains	83:99	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.
32935859	12	91	theme	varying	1526:1532	arg1	rates					1534:1538	varying rates	1526:1538	varying rates	1526:1538	Simultaneous water gain and solid loss in the grain was observed throughout the process at varying rates.
32935859	7	92	from	°C	1029:1030	arg1	m²/s					1017:1020	9.48 × 10-10 m²/s	1004:1020	9.48 × 10-10 m²/s	1004:1020	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	7	92	from	°C	1029:1030	arg1	°C					997:998	10-10 at 35 °C	985:998	10-10 at 35 °C	985:998	The water diffusivities varied from 5.492 × 10-10 to 13.84 × 10-10 m²/s when soaking temperature was increased from 35 to 100 °C. Similarly, solid diffusivities vary between 6.27 × 10-10 at 35 °C and 9.48 × 10-10 m²/s at 100 °C.
32935859	16	93	theme	chemical	1910:1917	arg1	dynamics					1890:1897	the dynamics	1886:1897	the dynamics of various chemical, physical	1886:1927	Pigeon pea being a leading legume, understanding of the dynamics of various chemical, physical, and compositional changes during soaking is very much required for a process design.
32935859	0	94	theme	grains	94:99	arg1	soaking					72:78	soaking	72:78	soaking of pigeon pea grains	72:99	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.
32935859	9	95	theme	distinct	1182:1189	arg1	stages					1191:1196	three distinct stages	1176:1196	three distinct stages	1176:1196	The mass transfer process has been identified with three distinct stages.
32935859	5	96	theme	mass	568:571	arg1	dynamics					582:589	the mass transfer dynamics	564:589	the mass transfer dynamics of simultaneous water gain and solid loss taking place during soaking	564:659	In the present investigation, the mass transfer dynamics of simultaneous water gain and solid loss taking place during soaking was studied .
32935859	11	97	theme	second	1286:1291	arg1	stage					1293:1297	The second stage	1282:1297	The second stage	1282:1297	The second stage was marked at 5% of solid loss and characterized by solid loss, while the third stage contributed to the starch gelatinization process.
32935859	0	98	theme	transfer	5:12	arg1	dynamics					14:21	Mass transfer dynamics	0:21	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.	0:100	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.
32935859	16	99	theme	process	1999:2005	arg1	design					2007:2012	a process design	1997:2012	a process design	1997:2012	Pigeon pea being a leading legume, understanding of the dynamics of various chemical, physical, and compositional changes during soaking is very much required for a process design.
32935859	16	100	theme	Pigeon	1834:1839	arg1	pea					1841:1843	Pigeon pea	1834:1843	Pigeon pea being a leading legume, understanding of the dynamics of various chemical, physical, and compositional changes during soaking	1834:1969	Pigeon pea being a leading legume, understanding of the dynamics of various chemical, physical, and compositional changes during soaking is very much required for a process design.
32935859	4	101	theme	quality	511:517	arg1	retention					494:502	retention	494:502	retention of its quality and nutrition	494:531	Insights into its mass transfer dynamics enable the design and optimization of processing conditions with due consideration of retention of its quality and nutrition.
32935859	15	102	theme	Various	1753:1759	arg1	changes					1787:1793	Various desirable and undesirable changes	1753:1793	Various desirable and undesirable changes	1753:1793	Various desirable and undesirable changes take place during the soaking process.
32935859	5	103	theme	present	541:547	arg1	investigation					549:561	the present investigation	537:561	the present investigation	537:561	In the present investigation, the mass transfer dynamics of simultaneous water gain and solid loss taking place during soaking was studied .
32935859	4	104	theme	nutrition	523:531	arg1	retention					494:502	retention	494:502	retention of its quality and nutrition	494:531	Insights into its mass transfer dynamics enable the design and optimization of processing conditions with due consideration of retention of its quality and nutrition.
32935859	0	105	theme	water	39:43	arg1	gain					45:48	simultaneous water gain	26:48	simultaneous water gain	26:48	Mass transfer dynamics of simultaneous water gain and solid loss during soaking of pigeon pea grains.
32935859	4	106	dep	design	419:424	arg1	the					415:417	the	415:417	the	415:417	Insights into its mass transfer dynamics enable the design and optimization of processing conditions with due consideration of retention of its quality and nutrition.
32935859	12	107	from	gain	1454:1457	arg1	grain					1481:1485	the grain	1477:1485	the grain	1477:1485	Simultaneous water gain and solid loss in the grain was observed throughout the process at varying rates.
32935859	6	108	theme	upper	769:773	arg1	temperatures					790:801	the lower and upper gelatinization temperatures	755:801	the lower and upper gelatinization temperatures	755:801	The experimental samples were soaked at 35, 50, 75, 85, and 100 °C to represent the lower and upper gelatinization temperatures.
32935859	6	109	theme	lower	759:763	arg1	temperatures					790:801	the lower and upper gelatinization temperatures	755:801	the lower and upper gelatinization temperatures	755:801	The experimental samples were soaked at 35, 50, 75, 85, and 100 °C to represent the lower and upper gelatinization temperatures.
32935859	3	110	theme	consumable	350:359	arg1	form					361:364	a consumable form	348:364	a consumable form	348:364	Soaking is one of the mandatory unit operation required to convert it from raw to a consumable form.
32935859	10	111	theme	first	1203:1207	arg1	stage					1209:1213	The first stage	1199:1213	The first stage	1199:1213	The first stage was characterized by void filling, expansion, and solid hydration.
32935859	17	112	theme	quality	2169:2175	arg1	attributes					2177:2186	quality attributes	2169:2186	quality attributes	2169:2186	Also the representation of these behaviors in mathematical models is essential to further understand and optimize the operations for maximum retention of quality attributes, minimum wastage, and low-energy consumption.
32935859	13	113	theme	soaking	1633:1639	arg1	behavior					1641:1648	pigeon pea soaking behavior	1622:1648	pigeon pea soaking behavior	1622:1648	The insights into mass transfers from this study can help in further modeling of pigeon pea soaking behavior.
32935859	6	114	theme	experimental	679:690	arg1	samples					692:698	The experimental samples	675:698	The experimental samples	675:698	The experimental samples were soaked at 35, 50, 75, 85, and 100 °C to represent the lower and upper gelatinization temperatures.
32475444	2	0	theme	200 mg/kg	495:503	arg1	CS					505:506	200 mg/kg CS	495:506	200 mg/kg CS	495:506	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	0	theme	200 mg/kg	495:503	arg1	groups					417:422	the following 4 main groups	396:422	the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups	396:560	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	1	theme	growing	309:315	arg1	geese					324:328	320 (28-day-old) growing Huoyan geese	292:328	320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight	292:367	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	1	theme	growing	309:315	arg1	balance					335:341	sex balance	331:341	sex balance	331:341	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	5	2	theme	total	1225:1229	arg1	concentration					1236:1248	total PUFA concentration	1225:1248	total PUFA concentration	1225:1248	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	3	theme	fatty	1146:1150	arg1	PUFA					1159:1162	PUFA	1159:1162	PUFA	1159:1162	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	3	theme	fatty	1146:1150	arg1	acids					1152:1156	polyunsaturated fatty acids	1130:1156	polyunsaturated fatty acids (PUFA)	1130:1163	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	4	theme	monounsaturated	1084:1098	arg1	acids					1106:1110	total monounsaturated fatty acids	1078:1110	total monounsaturated fatty acids	1078:1110	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	4	theme	monounsaturated	1084:1098	arg1	acids					981:985	total nonessential amino acids	956:985	total nonessential amino acids	956:985	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	4	5	dep	breast	808:813	arg1	muscle					825:830	muscle	825:830	muscle	825:830	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	1	6	theme	dietary	175:181	arg1	supplementation					183:197	dietary supplementation	175:197	dietary supplementation of chitosan (CS)	175:214	This present study was conducted to investigate the effects of dietary supplementation of chitosan (CS) on carcass composition and meat quality in growing Huoyan geese.
32475444	4	7	theme	lower	717:721	arg1	percentage					737:746	lower abdominal fat percentage	717:746	lower abdominal fat percentage	717:746	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	0	8	from	composition	58:68	arg1	geese					105:109	growing Huoyan geese	90:109	growing Huoyan geese	90:109	Effects of dietary supplementation of chitosan on carcass composition and meat quality in growing Huoyan geese.
32475444	4	9	theme	fat	733:735	arg1	percentage					737:746	lower abdominal fat percentage	717:746	lower abdominal fat percentage	717:746	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	2	10	theme	CS400	548:552	arg1	groups					555:560	400 mg/kg CS (CS400) groups	534:560	400 mg/kg CS (CS400) groups	534:560	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	5	11	from	ratio	1198:1202	arg1	muscle					1285:1290	breast muscle	1278:1290	breast muscle	1278:1290	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	4	12	theme	fat	778:780	arg1	content					782:788	crude fat content	772:788	crude fat content	772:788	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	5	13	theme	total	1017:1021	arg1	acids					981:985	total nonessential amino acids	956:985	total nonessential amino acids	956:985	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	13	theme	total	1017:1021	arg1	acids					1029:1033	total amino acids	1017:1033	total amino acids	1017:1033	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	2	14	theme	basal	425:429	arg1	diet					431:434	basal diet	425:434	basal diet (control)	425:444	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	14	theme	basal	425:429	arg1	control					437:443	control	437:443	control	437:443	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	14	theme	basal	425:429	arg1	groups					417:422	the following 4 main groups	396:422	the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups	396:560	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	0	15	theme	meat	74:77	arg1	quality					79:85	meat quality	74:85	meat quality	74:85	Effects of dietary supplementation of chitosan on carcass composition and meat quality in growing Huoyan geese.
32475444	5	16	from	SFA	1220:1222	arg1	muscle					1285:1290	breast muscle	1278:1290	breast muscle	1278:1290	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	4	17	theme	shear	759:763	arg1	force					765:769	shear force	759:769	shear force	759:769	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	0	18	from	Effects	0:6	arg1	composition					58:68	carcass composition	50:68	carcass composition	50:68	Effects of dietary supplementation of chitosan on carcass composition and meat quality in growing Huoyan geese.
32475444	0	18	from	Effects	0:6	arg1	quality					79:85	meat quality	74:85	meat quality	74:85	Effects of dietary supplementation of chitosan on carcass composition and meat quality in growing Huoyan geese.
32475444	5	19	theme	fatty	1180:1184	arg1	acids					1186:1190	saturated fatty acids	1170:1190	saturated fatty acids	1170:1190	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	2	20	theme	basal	521:525	arg1	diet					527:530	basal diet	521:530	basal diet	521:530	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	20	theme	basal	521:525	arg1	groups					417:422	the following 4 main groups	396:422	the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups	396:560	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	5	21	theme	essential	994:1002	arg1	acids					1010:1014	total essential amino acids	988:1014	total essential amino acids	988:1014	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	21	theme	essential	994:1002	arg1	acids					981:985	total nonessential amino acids	956:985	total nonessential amino acids	956:985	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	0	22	theme	Huoyan	98:103	arg1	geese					105:109	growing Huoyan geese	90:109	growing Huoyan geese	90:109	Effects of dietary supplementation of chitosan on carcass composition and meat quality in growing Huoyan geese.
32475444	4	23	contain	had	713:715	arg2	percentage					737:746	lower abdominal fat percentage	717:746	lower abdominal fat percentage	717:746	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	23	contain	had	713:715	arg2	force					765:769	shear force	759:769	shear force	759:769	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	23	contain	had	713:715	arg2	value					752:756	b∗ value	749:756	b∗ value	749:756	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	23	contain	had	713:715	arg1	geese					692:696	the geese	688:696	the geese in CS200 group	688:711	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	23	contain	had	713:715	arg2	loss					800:803	drip loss	795:803	drip loss of breast and thigh muscle	795:830	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	23	contain	had	713:715	arg2	content					782:788	crude fat content	772:788	crude fat content	772:788	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	2	24	theme	CS	544:545	arg1	groups					555:560	400 mg/kg CS (CS400) groups	534:560	400 mg/kg CS (CS400) groups	534:560	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	5	25	theme	glutamic	916:923	arg1	ratio					1198:1202	higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio	909:1202	ratio	1198:1202	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	26	theme	control	1301:1307	arg1	group					1309:1313	the control group	1297:1313	the control group (P < 0.05)	1297:1324	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	26	theme	control	1301:1307	arg1	<					1318:1318	P < 0.05	1316:1323	P < 0.05	1316:1323	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	0	27	theme	dietary	11:17	arg1	supplementation					19:33	dietary supplementation	11:33	dietary supplementation of chitosan	11:45	Effects of dietary supplementation of chitosan on carcass composition and meat quality in growing Huoyan geese.
32475444	1	28	theme	Huoyan	267:272	arg1	geese					274:278	Huoyan geese	267:278	Huoyan geese	267:278	This present study was conducted to investigate the effects of dietary supplementation of chitosan (CS) on carcass composition and meat quality in growing Huoyan geese.
32475444	4	29	theme	drip	795:798	arg1	loss					800:803	drip loss	795:803	drip loss of breast and thigh muscle	795:830	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	6	30	theme	meat	1406:1409	arg1	quality					1411:1417	meat quality	1406:1417	meat quality	1406:1417	Taken together, these results indicated that addition of 200 mg/kg CS improved meat quality in growing Huoyan geese through altering slaughter performance, meat traits, amino acids, and fatty acids composition.
32475444	5	31	theme	total	1214:1218	arg1	SFA					1220:1222	lower total SFA	1208:1222	lower total SFA	1208:1222	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	2	32	theme	body	357:360	arg1	weight					362:367	similar body weight	349:367	similar body weight	349:367	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	5	33	theme	CS200	893:897	arg1	group					899:903	the CS200 group	889:903	the CS200 group	889:903	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	6	34	theme	CS	1394:1395	arg1	addition					1372:1379	addition	1372:1379	addition of 200 mg/kg CS	1372:1395	Taken together, these results indicated that addition of 200 mg/kg CS improved meat quality in growing Huoyan geese through altering slaughter performance, meat traits, amino acids, and fatty acids composition.
32475444	3	35	dep	includes	574:581	arg1	replicates					585:594	replicates	585:594	replicates with 20 geese per replicate	585:622	Each group includes 4 replicates with 20 geese per replicate, and the feeding trail lasted for 4 wk.
32475444	3	35	dep	includes	574:581	arg1	lasted					647:652	lasted	647:652	lasted for 4 wk	647:661	Each group includes 4 replicates with 20 geese per replicate, and the feeding trail lasted for 4 wk.
32475444	5	36	theme	total	1078:1082	arg1	acids					1106:1110	total monounsaturated fatty acids	1078:1110	total monounsaturated fatty acids	1078:1110	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	36	theme	total	1078:1082	arg1	acids					981:985	total nonessential amino acids	956:985	total nonessential amino acids	956:985	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	4	37	theme	P	865:865	arg1	group					858:862	the control group	846:862	the control group (P < 0.05)	846:873	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	37	theme	P	865:865	arg1	<					867:867	P < 0.05	865:872	P < 0.05	865:872	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	5	38	theme	P	1316:1316	arg1	group					1309:1313	the control group	1297:1313	the control group (P < 0.05)	1297:1324	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	38	theme	P	1316:1316	arg1	<					1318:1318	P < 0.05	1316:1323	P < 0.05	1316:1323	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	39	theme	nonessential	962:973	arg1	acids					1106:1110	total monounsaturated fatty acids	1078:1110	total monounsaturated fatty acids	1078:1110	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	39	theme	nonessential	962:973	arg1	acids					981:985	total nonessential amino acids	956:985	total nonessential amino acids	956:985	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	39	theme	nonessential	962:973	arg1	C20:5					1071:1075	C20:5	1071:1075	C20:5	1071:1075	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	39	theme	nonessential	962:973	arg1	acids					1029:1033	total amino acids	1017:1033	total amino acids	1017:1033	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	39	theme	nonessential	962:973	arg1	C22:0					1036:1040	C22:0	1036:1040	C22:0	1036:1040	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	39	theme	nonessential	962:973	arg1	acids					1010:1014	total essential amino acids	988:1014	total essential amino acids	988:1014	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	6	40	theme	slaughter	1460:1468	arg1	performance					1470:1480	slaughter performance	1460:1480	slaughter performance	1460:1480	Taken together, these results indicated that addition of 200 mg/kg CS improved meat quality in growing Huoyan geese through altering slaughter performance, meat traits, amino acids, and fatty acids composition.
32475444	2	41	theme	Huoyan	317:322	arg1	geese					324:328	320 (28-day-old) growing Huoyan geese	292:328	320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight	292:367	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	41	theme	Huoyan	317:322	arg1	balance					335:341	sex balance	331:341	sex balance	331:341	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	5	42	theme	polyunsaturated	1130:1144	arg1	PUFA					1159:1162	PUFA	1159:1162	PUFA	1159:1162	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	42	theme	polyunsaturated	1130:1144	arg1	acids					1152:1156	polyunsaturated fatty acids	1130:1156	polyunsaturated fatty acids (PUFA)	1130:1163	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	1	43	theme	meat	243:246	arg1	quality					248:254	meat quality	243:254	meat quality	243:254	This present study was conducted to investigate the effects of dietary supplementation of chitosan (CS) on carcass composition and meat quality in growing Huoyan geese.
32475444	5	44	dep	ratio	1198:1202	arg1	ratio					1269:1273	n-6:n-3 ratio	1261:1273	n-6:n-3 ratio	1261:1273	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	44	dep	ratio	1198:1202	arg1	acids					1106:1110	total monounsaturated fatty acids	1078:1110	total monounsaturated fatty acids	1078:1110	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	44	dep	ratio	1198:1202	arg1	acids					981:985	total nonessential amino acids	956:985	total nonessential amino acids	956:985	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	44	dep	ratio	1198:1202	arg1	valine					948:953	valine	948:953	valine	948:953	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	44	dep	ratio	1198:1202	arg1	C20:5					1071:1075	C20:5	1071:1075	C20:5	1071:1075	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	44	dep	ratio	1198:1202	arg1	SFA					1193:1195	SFA	1193:1195	SFA	1193:1195	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	44	dep	ratio	1198:1202	arg1	glycine					931:937	glycine	931:937	glycine	931:937	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	44	dep	ratio	1198:1202	arg1	acids					1029:1033	total amino acids	1017:1033	total amino acids	1017:1033	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	44	dep	ratio	1198:1202	arg1	C22:0					1036:1040	C22:0	1036:1040	C22:0	1036:1040	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	44	dep	ratio	1198:1202	arg1	acids					1010:1014	total essential amino acids	988:1014	total essential amino acids	988:1014	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	44	dep	ratio	1198:1202	arg1	lysine					940:945	lysine	940:945	lysine	940:945	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	44	dep	ratio	1198:1202	arg1	acids					1186:1190	saturated fatty acids	1170:1190	saturated fatty acids	1170:1190	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	6	45	dep	performance	1470:1480	arg1	composition					1525:1535	composition	1525:1535	composition	1525:1535	Taken together, these results indicated that addition of 200 mg/kg CS improved meat quality in growing Huoyan geese through altering slaughter performance, meat traits, amino acids, and fatty acids composition.
32475444	2	46	theme	basal	482:486	arg1	CS200					509:513	CS200	509:513	CS200	509:513	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	46	theme	basal	482:486	arg1	diet					488:491	basal diet	482:491	basal diet	482:491	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	46	theme	basal	482:486	arg1	groups					417:422	the following 4 main groups	396:422	the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups	396:560	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	6	47	theme	Huoyan	1430:1435	arg1	geese					1437:1441	Huoyan geese	1430:1441	Huoyan geese	1430:1441	Taken together, these results indicated that addition of 200 mg/kg CS improved meat quality in growing Huoyan geese through altering slaughter performance, meat traits, amino acids, and fatty acids composition.
32475444	5	48	theme	PUFA	1231:1234	arg1	concentration					1236:1248	total PUFA concentration	1225:1248	total PUFA concentration	1225:1248	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	6	49	theme	fatty	1513:1517	arg1	acids					1519:1523	fatty acids	1513:1523	fatty acids	1513:1523	Taken together, these results indicated that addition of 200 mg/kg CS improved meat quality in growing Huoyan geese through altering slaughter performance, meat traits, amino acids, and fatty acids composition.
32475444	5	50	theme	breast	1278:1283	arg1	muscle					1285:1290	breast muscle	1278:1290	breast muscle	1278:1290	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	51	theme	fatty	1100:1104	arg1	acids					1106:1110	total monounsaturated fatty acids	1078:1110	total monounsaturated fatty acids	1078:1110	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	51	theme	fatty	1100:1104	arg1	acids					981:985	total nonessential amino acids	956:985	total nonessential amino acids	956:985	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	52	dep	acids	981:985	arg1	concentration					1112:1124	concentration	1112:1124	concentration	1112:1124	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	52	dep	acids	981:985	arg1	PUFA					1159:1162	PUFA	1159:1162	PUFA	1159:1162	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	52	dep	acids	981:985	arg1	acids					1152:1156	polyunsaturated fatty acids	1130:1156	polyunsaturated fatty acids (PUFA)	1130:1163	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	1	53	theme	supplementation	183:197	arg1	effects					164:170	the effects	160:170	the effects of dietary supplementation of chitosan (CS) on carcass composition and meat quality	160:254	This present study was conducted to investigate the effects of dietary supplementation of chitosan (CS) on carcass composition and meat quality in growing Huoyan geese.
32475444	2	54	theme	100 mg/kg	460:468	arg1	CS					470:471	100 mg/kg CS	460:471	100 mg/kg CS	460:471	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	54	theme	100 mg/kg	460:468	arg1	groups					417:422	the following 4 main groups	396:422	the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups	396:560	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	0	55	from	quality	79:85	arg1	geese					105:109	growing Huoyan geese	90:109	growing Huoyan geese	90:109	Effects of dietary supplementation of chitosan on carcass composition and meat quality in growing Huoyan geese.
32475444	6	56	theme	amino	1496:1500	arg1	acids					1502:1506	amino acids	1496:1506	amino acids	1496:1506	Taken together, these results indicated that addition of 200 mg/kg CS improved meat quality in growing Huoyan geese through altering slaughter performance, meat traits, amino acids, and fatty acids composition.
32475444	1	57	theme	chitosan	202:209	arg1	supplementation					183:197	dietary supplementation	175:197	dietary supplementation of chitosan (CS)	175:214	This present study was conducted to investigate the effects of dietary supplementation of chitosan (CS) on carcass composition and meat quality in growing Huoyan geese.
32475444	4	58	theme	b∗	749:750	arg1	value					752:756	b∗ value	749:756	b∗ value	749:756	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	2	59	theme	basal	447:451	arg1	CS100					474:478	CS100	474:478	CS100	474:478	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	59	theme	basal	447:451	arg1	diet					453:456	basal diet	447:456	basal diet	447:456	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	59	theme	basal	447:451	arg1	groups					417:422	the following 4 main groups	396:422	the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups	396:560	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	5	60	contain	had	905:907	arg2	SFA					1220:1222	lower total SFA	1208:1222	lower total SFA	1208:1222	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	60	contain	had	905:907	arg2	concentration					1236:1248	total PUFA concentration	1225:1248	total PUFA concentration	1225:1248	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	60	contain	had	905:907	arg2	total					1255:1259	total	1255:1259	total	1255:1259	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	60	contain	had	905:907	arg2	ratio					1198:1202	higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio	909:1202	ratio	1198:1202	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	60	contain	had	905:907	arg1	group					899:903	the CS200 group	889:903	the CS200 group	889:903	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	61	theme	amino	1004:1008	arg1	acids					1010:1014	total essential amino acids	988:1014	total essential amino acids	988:1014	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	61	theme	amino	1004:1008	arg1	acids					981:985	total nonessential amino acids	956:985	total nonessential amino acids	956:985	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	1	62	theme	present	117:123	arg1	study					125:129	This present study	112:129	This present study	112:129	This present study was conducted to investigate the effects of dietary supplementation of chitosan (CS) on carcass composition and meat quality in growing Huoyan geese.
32475444	4	63	theme	abdominal	723:731	arg1	percentage					737:746	lower abdominal fat percentage	717:746	lower abdominal fat percentage	717:746	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	64	theme	crude	772:776	arg1	content					782:788	crude fat content	772:788	crude fat content	772:788	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	3	65	theme	feeding	633:639	arg1	trail					641:645	the feeding trail	629:645	the feeding trail	629:645	Each group includes 4 replicates with 20 geese per replicate, and the feeding trail lasted for 4 wk.
32475444	1	66	from	effects	164:170	arg1	composition					227:237	carcass composition	219:237	carcass composition	219:237	This present study was conducted to investigate the effects of dietary supplementation of chitosan (CS) on carcass composition and meat quality in growing Huoyan geese.
32475444	1	66	from	effects	164:170	arg1	quality					248:254	meat quality	243:254	meat quality	243:254	This present study was conducted to investigate the effects of dietary supplementation of chitosan (CS) on carcass composition and meat quality in growing Huoyan geese.
32475444	5	67	theme	saturated	1170:1178	arg1	acids					1186:1190	saturated fatty acids	1170:1190	saturated fatty acids	1170:1190	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	68	theme	total	988:992	arg1	acids					1010:1014	total essential amino acids	988:1014	total essential amino acids	988:1014	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	68	theme	total	988:992	arg1	acids					981:985	total nonessential amino acids	956:985	total nonessential amino acids	956:985	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	0	69	theme	growing	90:96	arg1	geese					105:109	growing Huoyan geese	90:109	growing Huoyan geese	90:109	Effects of dietary supplementation of chitosan on carcass composition and meat quality in growing Huoyan geese.
32475444	4	70	from	geese	692:696	arg1	group					707:711	CS200 group	701:711	CS200 group	701:711	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	2	71	dep	groups	417:422	arg1	groups					555:560	400 mg/kg CS (CS400) groups	534:560	400 mg/kg CS (CS400) groups	534:560	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	71	dep	groups	417:422	arg1	CS100					474:478	CS100	474:478	CS100	474:478	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	71	dep	groups	417:422	arg1	diet					527:530	basal diet	521:530	basal diet	521:530	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	71	dep	groups	417:422	arg1	diet					431:434	basal diet	425:434	basal diet (control)	425:444	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	71	dep	groups	417:422	arg1	diet					453:456	basal diet	447:456	basal diet	447:456	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	71	dep	groups	417:422	arg1	CS200					509:513	CS200	509:513	CS200	509:513	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	71	dep	groups	417:422	arg1	diet					488:491	basal diet	482:491	basal diet	482:491	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	71	dep	groups	417:422	arg1	control					437:443	control	437:443	control	437:443	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	71	dep	groups	417:422	arg1	groups					417:422	the following 4 main groups	396:422	the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups	396:560	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	4	72	theme	breast	808:813	arg1	loss					800:803	drip loss	795:803	drip loss of breast and thigh muscle	795:830	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	72	theme	breast	808:813	arg1	force					765:769	shear force	759:769	shear force	759:769	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	72	theme	breast	808:813	arg1	content					782:788	crude fat content	772:788	crude fat content	772:788	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	72	theme	breast	808:813	arg1	percentage					737:746	lower abdominal fat percentage	717:746	lower abdominal fat percentage	717:746	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	72	theme	breast	808:813	arg1	value					752:756	b∗ value	749:756	b∗ value	749:756	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	2	73	theme	400 mg/kg	534:542	arg1	groups					555:560	400 mg/kg CS (CS400) groups	534:560	400 mg/kg CS (CS400) groups	534:560	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	5	74	theme	amino	1023:1027	arg1	acids					981:985	total nonessential amino acids	956:985	total nonessential amino acids	956:985	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	74	theme	amino	1023:1027	arg1	acids					1029:1033	total amino acids	1017:1033	total amino acids	1017:1033	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	2	75	theme	sex	331:333	arg1	geese					324:328	320 (28-day-old) growing Huoyan geese	292:328	320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight	292:367	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	75	theme	sex	331:333	arg1	balance					335:341	sex balance	331:341	sex balance	331:341	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	0	76	theme	supplementation	19:33	arg1	Effects					0:6	Effects	0:6	Effects of dietary supplementation of chitosan on carcass composition and meat quality in growing Huoyan geese.	0:110	Effects of dietary supplementation of chitosan on carcass composition and meat quality in growing Huoyan geese.
32475444	5	77	theme	acid	925:928	arg1	ratio					1198:1202	higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio	909:1202	ratio	1198:1202	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	4	78	theme	thigh	819:823	arg1	loss					800:803	drip loss	795:803	drip loss of breast and thigh muscle	795:830	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	78	theme	thigh	819:823	arg1	force					765:769	shear force	759:769	shear force	759:769	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	78	theme	thigh	819:823	arg1	content					782:788	crude fat content	772:788	crude fat content	772:788	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	78	theme	thigh	819:823	arg1	percentage					737:746	lower abdominal fat percentage	717:746	lower abdominal fat percentage	717:746	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	78	theme	thigh	819:823	arg1	value					752:756	b∗ value	749:756	b∗ value	749:756	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	5	79	theme	lower	1208:1212	arg1	SFA					1220:1222	lower total SFA	1208:1222	lower total SFA	1208:1222	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	0	80	theme	chitosan	38:45	arg1	supplementation					19:33	dietary supplementation	11:33	dietary supplementation of chitosan	11:45	Effects of dietary supplementation of chitosan on carcass composition and meat quality in growing Huoyan geese.
32475444	5	81	from	concentration	1236:1248	arg1	muscle					1285:1290	breast muscle	1278:1290	breast muscle	1278:1290	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	2	82	theme	main	412:415	arg1	diet					527:530	basal diet	521:530	basal diet	521:530	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	82	theme	main	412:415	arg1	CS					505:506	200 mg/kg CS	495:506	200 mg/kg CS	495:506	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	82	theme	main	412:415	arg1	diet					431:434	basal diet	425:434	basal diet (control)	425:444	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	82	theme	main	412:415	arg1	diet					453:456	basal diet	447:456	basal diet	447:456	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	82	theme	main	412:415	arg1	CS					470:471	100 mg/kg CS	460:471	100 mg/kg CS	460:471	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	82	theme	main	412:415	arg1	diet					488:491	basal diet	482:491	basal diet	482:491	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	82	theme	main	412:415	arg1	groups					417:422	the following 4 main groups	396:422	the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups	396:560	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	83	theme	similar	349:355	arg1	weight					362:367	similar body weight	349:367	similar body weight	349:367	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	0	84	theme	carcass	50:56	arg1	composition					58:68	carcass composition	50:68	carcass composition	50:68	Effects of dietary supplementation of chitosan on carcass composition and meat quality in growing Huoyan geese.
32475444	2	85	theme	following	400:408	arg1	diet					527:530	basal diet	521:530	basal diet	521:530	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	85	theme	following	400:408	arg1	CS					505:506	200 mg/kg CS	495:506	200 mg/kg CS	495:506	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	85	theme	following	400:408	arg1	diet					431:434	basal diet	425:434	basal diet (control)	425:444	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	85	theme	following	400:408	arg1	diet					453:456	basal diet	447:456	basal diet	447:456	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	85	theme	following	400:408	arg1	CS					470:471	100 mg/kg CS	460:471	100 mg/kg CS	460:471	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	85	theme	following	400:408	arg1	diet					488:491	basal diet	482:491	basal diet	482:491	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	85	theme	following	400:408	arg1	groups					417:422	the following 4 main groups	396:422	the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups	396:560	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	6	86	theme	200 mg/kg	1384:1392	arg1	CS					1394:1395	200 mg/kg CS	1384:1395	200 mg/kg CS	1384:1395	Taken together, these results indicated that addition of 200 mg/kg CS improved meat quality in growing Huoyan geese through altering slaughter performance, meat traits, amino acids, and fatty acids composition.
32475444	2	87	theme	28-day-old	297:306	arg1	geese					324:328	320 (28-day-old) growing Huoyan geese	292:328	320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight	292:367	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	87	theme	28-day-old	297:306	arg1	balance					335:341	sex balance	331:341	sex balance	331:341	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	5	88	theme	higher	909:914	arg1	ratio					1198:1202	higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio	909:1202	ratio	1198:1202	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	4	89	theme	control	850:856	arg1	group					858:862	the control group	846:862	the control group (P < 0.05)	846:873	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	4	89	theme	control	850:856	arg1	<					867:867	P < 0.05	865:872	P < 0.05	865:872	The results showed that the geese in CS200 group had lower abdominal fat percentage, b∗ value, shear force, crude fat content, and drip loss of breast and thigh muscle than those in the control group (P < 0.05).
32475444	6	90	theme	meat	1483:1486	arg1	traits					1488:1493	meat traits	1483:1493	meat traits	1483:1493	Taken together, these results indicated that addition of 200 mg/kg CS improved meat quality in growing Huoyan geese through altering slaughter performance, meat traits, amino acids, and fatty acids composition.
32475444	2	91	theme	320	292:294	arg1	geese					324:328	320 (28-day-old) growing Huoyan geese	292:328	320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight	292:367	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	2	91	theme	320	292:294	arg1	balance					335:341	sex balance	331:341	sex balance	331:341	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	5	92	theme	total	956:960	arg1	acids					1106:1110	total monounsaturated fatty acids	1078:1110	total monounsaturated fatty acids	1078:1110	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	92	theme	total	956:960	arg1	acids					981:985	total nonessential amino acids	956:985	total nonessential amino acids	956:985	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	92	theme	total	956:960	arg1	C20:5					1071:1075	C20:5	1071:1075	C20:5	1071:1075	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	92	theme	total	956:960	arg1	acids					1029:1033	total amino acids	1017:1033	total amino acids	1017:1033	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	92	theme	total	956:960	arg1	C22:0					1036:1040	C22:0	1036:1040	C22:0	1036:1040	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	92	theme	total	956:960	arg1	acids					1010:1014	total essential amino acids	988:1014	total essential amino acids	988:1014	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	2	93	with	geese	324:328	arg1	weight					362:367	similar body weight	349:367	similar body weight	349:367	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	1	94	theme	carcass	219:225	arg1	composition					227:237	carcass composition	219:237	carcass composition	219:237	This present study was conducted to investigate the effects of dietary supplementation of chitosan (CS) on carcass composition and meat quality in growing Huoyan geese.
32475444	2	95	theme	geese	324:328	arg1	total					283:287	A total	281:287	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight	281:367	A total of 320 (28-day-old) growing Huoyan geese (sex balance) with similar body weight were randomly divided into the following 4 main groups: basal diet (control), basal diet + 100 mg/kg CS (CS100), basal diet + 200 mg/kg CS (CS200), and basal diet + 400 mg/kg CS (CS400) groups.
32475444	5	96	theme	amino	975:979	arg1	acids					1106:1110	total monounsaturated fatty acids	1078:1110	total monounsaturated fatty acids	1078:1110	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	96	theme	amino	975:979	arg1	acids					981:985	total nonessential amino acids	956:985	total nonessential amino acids	956:985	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	96	theme	amino	975:979	arg1	C20:5					1071:1075	C20:5	1071:1075	C20:5	1071:1075	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	96	theme	amino	975:979	arg1	acids					1029:1033	total amino acids	1017:1033	total amino acids	1017:1033	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	96	theme	amino	975:979	arg1	C22:0					1036:1040	C22:0	1036:1040	C22:0	1036:1040	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
32475444	5	96	theme	amino	975:979	arg1	acids					1010:1014	total essential amino acids	988:1014	total essential amino acids	988:1014	In addition, the CS200 group had higher glutamic acid, glycine, lysine, valine, total nonessential amino acids, total essential amino acids, total amino acids, C22:0, C16:1, C18:1, C20:1, C20:2, C20:5, total monounsaturated fatty acids concentration and polyunsaturated fatty acids (PUFA), and saturated fatty acids (SFA) ratio and lower total SFA, total PUFA concentration, and total n-6:n-3 ratio in breast muscle than the control group (P < 0.05).
33035600	1	0	theme	end-stage	311:319	arg1	ESRD					336:339	ESRD	336:339	ESRD	336:339	AIM To assess the relationship between acarbose and hepatotoxicity, cardiovascular disease (CVD), and mortality among type 2 diabetes (T2D) patients with end-stage renal disease (ESRD).
33035600	1	0	theme	end-stage	311:319	arg1	disease					327:333	end-stage renal disease	311:333	end-stage renal disease (ESRD)	311:340	AIM To assess the relationship between acarbose and hepatotoxicity, cardiovascular disease (CVD), and mortality among type 2 diabetes (T2D) patients with end-stage renal disease (ESRD).
33035600	8	1	theme	cardiovascular	1666:1679	arg1	safety					1681:1686	hepatic and cardiovascular safety	1654:1686	hepatic and cardiovascular safety	1654:1686	CONCLUSION Acarbose used in real-world T2D patients with ESRD may have hepatic and cardiovascular safety.
33035600	4	2	theme	supplies	643:650	arg1	numbers					614:620	the numbers	610:620	the numbers of the 30-day drug's supplies and dosages (measured by defined daily doses; DDDs)	610:702	The use of acarbose was quantified as the numbers of the 30-day drug's supplies and dosages (measured by defined daily doses; DDDs), respectively.
33035600	4	2	theme	supplies	643:650	arg1	use					576:578	The use	572:578	The use of acarbose	572:590	The use of acarbose was quantified as the numbers of the 30-day drug's supplies and dosages (measured by defined daily doses; DDDs), respectively.
33035600	6	3	theme	aforementioned	1271:1284	arg1	outcomes					1286:1293	three aforementioned outcomes	1265:1293	three aforementioned outcomes	1265:1293	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	1	4	theme	renal	321:325	arg1	ESRD					336:339	ESRD	336:339	ESRD	336:339	AIM To assess the relationship between acarbose and hepatotoxicity, cardiovascular disease (CVD), and mortality among type 2 diabetes (T2D) patients with end-stage renal disease (ESRD).
33035600	1	4	theme	renal	321:325	arg1	disease					327:333	end-stage renal disease	311:333	end-stage renal disease (ESRD)	311:340	AIM To assess the relationship between acarbose and hepatotoxicity, cardiovascular disease (CVD), and mortality among type 2 diabetes (T2D) patients with end-stage renal disease (ESRD).
33035600	7	5	theme	diabetes	1521:1528	arg1	duration					1530:1537	a longer diabetes duration	1512:1537	a longer diabetes duration	1512:1537	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	5	6	theme	mortality	833:841	arg1	outcomes					843:850	mortality outcomes	833:850	mortality outcomes	833:850	Time-varying Cox models were applied to evaluate the association of acarbose use with hepatic, cardiovascular and mortality outcomes, with adjustment for patients' demographics, comorbidities, diabetes severity, and co-medications.
33035600	7	7	theme	acarbose	1438:1445	arg1	use					1447:1449	acarbose use	1438:1449	acarbose use	1438:1449	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	0	8	theme	renal	92:96	arg1	disease					98:104	end-stage renal disease	82:104	end-stage renal disease	82:104	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.
33035600	0	9	with	patients	68:75	arg1	disease					98:104	end-stage renal disease	82:104	end-stage renal disease	82:104	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.
33035600	5	10	theme	Time-varying	719:730	arg1	models					736:741	Time-varying Cox models	719:741	Time-varying Cox models	719:741	Time-varying Cox models were applied to evaluate the association of acarbose use with hepatic, cardiovascular and mortality outcomes, with adjustment for patients' demographics, comorbidities, diabetes severity, and co-medications.
33035600	7	11	theme	use	1447:1449	arg1	outcomes					1426:1433	the favorable study outcomes	1406:1433	the favorable study outcomes of acarbose use	1406:1449	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	7	11	theme	use	1447:1449	arg1	apparent					1461:1468	apparent	1461:1468	apparent	1461:1468	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	0	12	theme	end-stage	82:90	arg1	disease					98:104	end-stage renal disease	82:104	end-stage renal disease	82:104	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.
33035600	8	13	theme	Acarbose	1594:1601	arg1	CONCLUSION					1583:1592	CONCLUSION Acarbose	1583:1601	CONCLUSION Acarbose used in real-world T2D patients with ESRD	1583:1643	CONCLUSION Acarbose used in real-world T2D patients with ESRD may have hepatic and cardiovascular safety.
33035600	3	14	theme	subjects	506:513	arg1	subjects					506:513	subjects	506:513	subjects	506:513	19.3% of subjects were newly initiated with acarbose during the follow-up.
33035600	3	14	theme	subjects	506:513	arg1	%					501:501	19.3%	497:501	19.3% of subjects	497:513	19.3% of subjects were newly initiated with acarbose during the follow-up.
33035600	8	15	theme	real-world	1611:1620	arg1	patients					1626:1633	real-world T2D patients	1611:1633	real-world T2D patients with ESRD	1611:1643	CONCLUSION Acarbose used in real-world T2D patients with ESRD may have hepatic and cardiovascular safety.
33035600	4	16	theme	defined	677:683	arg1	doses					691:695	defined daily doses	677:695	defined daily doses	677:695	The use of acarbose was quantified as the numbers of the 30-day drug's supplies and dosages (measured by defined daily doses; DDDs), respectively.
33035600	5	17	theme	acarbose	787:794	arg1	use					796:798	acarbose use	787:798	acarbose use	787:798	Time-varying Cox models were applied to evaluate the association of acarbose use with hepatic, cardiovascular and mortality outcomes, with adjustment for patients' demographics, comorbidities, diabetes severity, and co-medications.
33035600	5	18	theme	Cox	732:734	arg1	models					736:741	Time-varying Cox models	719:741	Time-varying Cox models	719:741	Time-varying Cox models were applied to evaluate the association of acarbose use with hepatic, cardiovascular and mortality outcomes, with adjustment for patients' demographics, comorbidities, diabetes severity, and co-medications.
33035600	7	19	with	patients	1476:1483	arg1	diabetes					1502:1509	more severe diabetes	1490:1509	more severe diabetes	1490:1509	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	7	19	with	patients	1476:1483	arg1	absence					1543:1549	absence	1543:1549	absence of established CVD at baseline	1543:1580	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	7	19	with	patients	1476:1483	arg1	duration					1530:1537	a longer diabetes duration	1512:1537	a longer diabetes duration	1512:1537	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	6	20	theme	acarbose	1232:1239	arg1	exposure					1241:1248	acarbose exposure	1232:1248	acarbose exposure	1232:1248	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	5	21	theme	diabetes	912:919	arg1	severity					921:928	diabetes severity	912:928	diabetes severity	912:928	Time-varying Cox models were applied to evaluate the association of acarbose use with hepatic, cardiovascular and mortality outcomes, with adjustment for patients' demographics, comorbidities, diabetes severity, and co-medications.
33035600	5	21	theme	diabetes	912:919	arg1	demographics					883:894	patients' demographics	873:894	patients' demographics	873:894	Time-varying Cox models were applied to evaluate the association of acarbose use with hepatic, cardiovascular and mortality outcomes, with adjustment for patients' demographics, comorbidities, diabetes severity, and co-medications.
33035600	7	22	theme	longer	1514:1519	arg1	duration					1530:1537	a longer diabetes duration	1512:1537	a longer diabetes duration	1512:1537	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	2	23	theme	T2D	358:360	arg1	patients					362:369	32,531 T2D patients	351:369	METHODS 32,531 T2D patients with ESRD	343:379	METHODS 32,531 T2D patients with ESRD were identified from Taiwan's National Health Insurance Research Database in 2000~∼2012 and followed up until 2013.
33035600	2	24	theme	National	411:418	arg1	Database					446:453	Taiwan's National Health Insurance Research Database	402:453	Taiwan's National Health Insurance Research Database	402:453	METHODS 32,531 T2D patients with ESRD were identified from Taiwan's National Health Insurance Research Database in 2000~∼2012 and followed up until 2013.
33035600	7	25	from	duration	1530:1537	arg1	baseline					1573:1580	baseline	1573:1580	baseline	1573:1580	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	2	26	with	patients	362:369	arg1	ESRD					376:379	ESRD	376:379	ESRD	376:379	METHODS 32,531 T2D patients with ESRD were identified from Taiwan's National Health Insurance Research Database in 2000~∼2012 and followed up until 2013.
33035600	7	27	theme	study	1420:1424	arg1	outcomes					1426:1433	the favorable study outcomes	1406:1433	the favorable study outcomes of acarbose use	1406:1449	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	7	27	theme	study	1420:1424	arg1	apparent					1461:1468	apparent	1461:1468	apparent	1461:1468	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	7	28	from	absence	1543:1549	arg1	baseline					1573:1580	baseline	1573:1580	baseline	1573:1580	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	0	29	theme	Hepatic	0:6	arg1	safety					27:32	Hepatic and cardiovascular safety	0:32	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.	0:155	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.
33035600	8	30	theme	T2D	1622:1624	arg1	patients					1626:1633	real-world T2D patients	1611:1633	real-world T2D patients with ESRD	1611:1643	CONCLUSION Acarbose used in real-world T2D patients with ESRD may have hepatic and cardiovascular safety.
33035600	6	31	theme	all-cause	1068:1076	arg1	mortality					1078:1086	all-cause mortality	1068:1086	all-cause mortality	1068:1086	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	8	32	with	patients	1626:1633	arg1	ESRD					1640:1643	ESRD	1640:1643	ESRD	1640:1643	CONCLUSION Acarbose used in real-world T2D patients with ESRD may have hepatic and cardiovascular safety.
33035600	6	33	theme	acarbose	994:1001	arg1	exposure					1003:1010	acarbose exposure	994:1010	acarbose exposure	994:1010	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	1	34	theme	type	275:278	arg1	T2D					292:294	T2D	292:294	T2D	292:294	AIM To assess the relationship between acarbose and hepatotoxicity, cardiovascular disease (CVD), and mortality among type 2 diabetes (T2D) patients with end-stage renal disease (ESRD).
33035600	1	34	theme	type	275:278	arg1	diabetes					282:289	type 2 diabetes	275:289	type 2 diabetes (T2D) patients with end-stage renal disease (ESRD)	275:340	AIM To assess the relationship between acarbose and hepatotoxicity, cardiovascular disease (CVD), and mortality among type 2 diabetes (T2D) patients with end-stage renal disease (ESRD).
33035600	0	35	theme	nationwide	109:118	arg1	study					150:154	A nationwide population-based longitudinal study	107:154	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.	0:155	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.
33035600	6	36	from	increase	982:989	arg1	exposure					1003:1010	acarbose exposure	994:1010	acarbose exposure	994:1010	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	6	36	from	increase	982:989	arg1	risks					1017:1021	the risks	1013:1021	the risks of hepatic injury	1013:1039	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	6	36	from	increase	982:989	arg1	mortality					1078:1086	all-cause mortality	1068:1086	all-cause mortality	1068:1086	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	6	36	from	increase	982:989	arg1	events					1056:1061	composite CVD events	1042:1061	composite CVD events	1042:1061	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	4	37	dep	dosages	656:662	arg1	measured					665:672	measured	665:672	measured by defined daily doses; DDDs	665:701	The use of acarbose was quantified as the numbers of the 30-day drug's supplies and dosages (measured by defined daily doses; DDDs), respectively.
33035600	0	38	theme	cardiovascular	12:25	arg1	safety					27:32	Hepatic and cardiovascular safety	0:32	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.	0:155	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.
33035600	4	39	theme	daily	685:689	arg1	doses					691:695	defined daily doses	677:695	defined daily doses	677:695	The use of acarbose was quantified as the numbers of the 30-day drug's supplies and dosages (measured by defined daily doses; DDDs), respectively.
33035600	7	40	theme	subgroup	1387:1394	arg1	analyses					1396:1403	subgroup analyses	1387:1403	subgroup analyses	1387:1403	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	4	41	theme	acarbose	583:590	arg1	numbers					614:620	the numbers	610:620	the numbers of the 30-day drug's supplies and dosages (measured by defined daily doses; DDDs)	610:702	The use of acarbose was quantified as the numbers of the 30-day drug's supplies and dosages (measured by defined daily doses; DDDs), respectively.
33035600	4	41	theme	acarbose	583:590	arg1	use					576:578	The use	572:578	The use of acarbose	572:590	The use of acarbose was quantified as the numbers of the 30-day drug's supplies and dosages (measured by defined daily doses; DDDs), respectively.
33035600	0	42	theme	acarbose	37:44	arg1	safety					27:32	Hepatic and cardiovascular safety	0:32	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.	0:155	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.
33035600	1	43	theme	diabetes	282:289	arg1	patients					297:304	type 2 diabetes (T2D) patients	275:304	type 2 diabetes (T2D) patients with end-stage renal disease (ESRD)	275:340	AIM To assess the relationship between acarbose and hepatotoxicity, cardiovascular disease (CVD), and mortality among type 2 diabetes (T2D) patients with end-stage renal disease (ESRD).
33035600	0	44	theme	longitudinal	137:148	arg1	study					150:154	A nationwide population-based longitudinal study	107:154	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.	0:155	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.
33035600	6	45	theme	supply	975:980	arg1	increase					982:989	each 30-day supply increase	963:989	each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality	963:1086	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	2	46	theme	Research	437:444	arg1	Database					446:453	Taiwan's National Health Insurance Research Database	402:453	Taiwan's National Health Insurance Research Database	402:453	METHODS 32,531 T2D patients with ESRD were identified from Taiwan's National Health Insurance Research Database in 2000~∼2012 and followed up until 2013.
33035600	8	47	theme	hepatic	1654:1660	arg1	safety					1681:1686	hepatic and cardiovascular safety	1654:1686	hepatic and cardiovascular safety	1654:1686	CONCLUSION Acarbose used in real-world T2D patients with ESRD may have hepatic and cardiovascular safety.
33035600	0	48	theme	population-based	120:135	arg1	study					150:154	A nationwide population-based longitudinal study	107:154	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.	0:155	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.
33035600	6	49	theme	interval	1137:1144	arg1	%					1151:1151	95% confidence interval: 6-12%	1122:1151	95% confidence interval: 6-12%	1122:1151	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	6	49	theme	interval	1137:1144	arg1	%					1119:1119	9%	1118:1119	9% (95% confidence interval: 6-12%)	1118:1152	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	6	50	theme	30-day	968:973	arg1	increase					982:989	each 30-day supply increase	963:989	each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality	963:1086	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	2	51	theme	Insurance	427:435	arg1	Database					446:453	Taiwan's National Health Insurance Research Database	402:453	Taiwan's National Health Insurance Research Database	402:453	METHODS 32,531 T2D patients with ESRD were identified from Taiwan's National Health Insurance Research Database in 2000~∼2012 and followed up until 2013.
33035600	6	52	theme	confidence	1126:1135	arg1	%					1151:1151	95% confidence interval: 6-12%	1122:1151	95% confidence interval: 6-12%	1122:1151	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	6	52	theme	confidence	1126:1135	arg1	%					1119:1119	9%	1118:1119	9% (95% confidence interval: 6-12%)	1118:1152	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	6	53	theme	injury	1034:1039	arg1	exposure					1003:1010	acarbose exposure	994:1010	acarbose exposure	994:1010	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	6	53	theme	injury	1034:1039	arg1	risks					1017:1021	the risks	1013:1021	the risks of hepatic injury	1013:1039	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	6	53	theme	injury	1034:1039	arg1	mortality					1078:1086	all-cause mortality	1068:1086	all-cause mortality	1068:1086	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	6	53	theme	injury	1034:1039	arg1	events					1056:1061	composite CVD events	1042:1061	composite CVD events	1042:1061	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	4	54	theme	dosages	656:662	arg1	numbers					614:620	the numbers	610:620	the numbers of the 30-day drug's supplies and dosages (measured by defined daily doses; DDDs)	610:702	The use of acarbose was quantified as the numbers of the 30-day drug's supplies and dosages (measured by defined daily doses; DDDs), respectively.
33035600	4	54	theme	dosages	656:662	arg1	use					576:578	The use	572:578	The use of acarbose	572:590	The use of acarbose was quantified as the numbers of the 30-day drug's supplies and dosages (measured by defined daily doses; DDDs), respectively.
33035600	2	55	theme	Health	420:425	arg1	Database					446:453	Taiwan's National Health Insurance Research Database	402:453	Taiwan's National Health Insurance Research Database	402:453	METHODS 32,531 T2D patients with ESRD were identified from Taiwan's National Health Insurance Research Database in 2000~∼2012 and followed up until 2013.
33035600	5	56	with	association	772:782	arg1	cardiovascular					814:827	cardiovascular	814:827	cardiovascular	814:827	Time-varying Cox models were applied to evaluate the association of acarbose use with hepatic, cardiovascular and mortality outcomes, with adjustment for patients' demographics, comorbidities, diabetes severity, and co-medications.
33035600	5	56	with	association	772:782	arg1	outcomes					843:850	mortality outcomes	833:850	mortality outcomes	833:850	Time-varying Cox models were applied to evaluate the association of acarbose use with hepatic, cardiovascular and mortality outcomes, with adjustment for patients' demographics, comorbidities, diabetes severity, and co-medications.
33035600	5	56	with	association	772:782	arg1	hepatic					805:811	hepatic	805:811	hepatic	805:811	Time-varying Cox models were applied to evaluate the association of acarbose use with hepatic, cardiovascular and mortality outcomes, with adjustment for patients' demographics, comorbidities, diabetes severity, and co-medications.
33035600	6	57	from	increase	1220:1227	arg1	exposure					1241:1248	acarbose exposure	1232:1248	acarbose exposure	1232:1248	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	6	58	theme	%	1124:1124	arg1	%					1151:1151	95% confidence interval: 6-12%	1122:1151	95% confidence interval: 6-12%	1122:1151	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	6	58	theme	%	1124:1124	arg1	%					1119:1119	9%	1118:1119	9% (95% confidence interval: 6-12%)	1118:1152	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	7	59	theme	established	1554:1564	arg1	CVD					1566:1568	established CVD	1554:1568	established CVD at baseline	1554:1580	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	6	60	theme	CVD	1052:1054	arg1	events					1056:1061	composite CVD events	1042:1061	composite CVD events	1042:1061	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	7	61	theme	severe	1495:1500	arg1	diabetes					1502:1509	more severe diabetes	1490:1509	more severe diabetes	1490:1509	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	7	62	from	diabetes	1502:1509	arg1	baseline					1573:1580	baseline	1573:1580	baseline	1573:1580	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	0	63	dep	safety	27:32	arg1	patients					68:75	patients	68:75	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.	0:155	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.
33035600	0	63	dep	safety	27:32	arg1	study					150:154	A nationwide population-based longitudinal study	107:154	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.	0:155	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.
33035600	1	64	with	patients	297:304	arg1	ESRD					336:339	ESRD	336:339	ESRD	336:339	AIM To assess the relationship between acarbose and hepatotoxicity, cardiovascular disease (CVD), and mortality among type 2 diabetes (T2D) patients with end-stage renal disease (ESRD).
33035600	1	64	with	patients	297:304	arg1	disease					327:333	end-stage renal disease	311:333	end-stage renal disease (ESRD)	311:340	AIM To assess the relationship between acarbose and hepatotoxicity, cardiovascular disease (CVD), and mortality among type 2 diabetes (T2D) patients with end-stage renal disease (ESRD).
33035600	6	65	theme	composite	1042:1050	arg1	events					1056:1061	composite CVD events	1042:1061	composite CVD events	1042:1061	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	1	66	theme	cardiovascular	225:238	arg1	CVD					249:251	CVD	249:251	CVD	249:251	AIM To assess the relationship between acarbose and hepatotoxicity, cardiovascular disease (CVD), and mortality among type 2 diabetes (T2D) patients with end-stage renal disease (ESRD).
33035600	1	66	theme	cardiovascular	225:238	arg1	disease					240:246	cardiovascular disease	225:246	cardiovascular disease (CVD)	225:252	AIM To assess the relationship between acarbose and hepatotoxicity, cardiovascular disease (CVD), and mortality among type 2 diabetes (T2D) patients with end-stage renal disease (ESRD).
33035600	7	67	theme	CVD	1566:1568	arg1	diabetes					1502:1509	more severe diabetes	1490:1509	more severe diabetes	1490:1509	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	7	67	theme	CVD	1566:1568	arg1	absence					1543:1549	absence	1543:1549	absence of established CVD at baseline	1543:1580	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	7	67	theme	CVD	1566:1568	arg1	duration					1530:1537	a longer diabetes duration	1512:1537	a longer diabetes duration	1512:1537	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	2	68	dep	METHODS	343:349	arg1	patients					362:369	32,531 T2D patients	351:369	METHODS 32,531 T2D patients with ESRD	343:379	METHODS 32,531 T2D patients with ESRD were identified from Taiwan's National Health Insurance Research Database in 2000~∼2012 and followed up until 2013.
33035600	7	69	from	analyses	1396:1403	arg1	outcomes					1426:1433	the favorable study outcomes	1406:1433	the favorable study outcomes of acarbose use	1406:1449	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	7	69	from	analyses	1396:1403	arg1	apparent					1461:1468	apparent	1461:1468	apparent	1461:1468	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	6	70	theme	hepatic	1026:1032	arg1	injury					1034:1039	hepatic injury	1026:1039	hepatic injury	1026:1039	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	7	71	theme	favorable	1410:1418	arg1	outcomes					1426:1433	the favorable study outcomes	1406:1433	the favorable study outcomes of acarbose use	1406:1449	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	7	71	theme	favorable	1410:1418	arg1	apparent					1461:1468	apparent	1461:1468	apparent	1461:1468	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	6	72	theme	30-day	1209:1214	arg1	increase					1220:1227	each 30-day DDD increase	1204:1227	each 30-day DDD increase in acarbose exposure	1204:1248	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	7	73	from	baseline	1573:1580	arg1	diabetes					1502:1509	more severe diabetes	1490:1509	more severe diabetes	1490:1509	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	7	73	from	baseline	1573:1580	arg1	absence					1543:1549	absence	1543:1549	absence of established CVD at baseline	1543:1580	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	7	73	from	baseline	1573:1580	arg1	CVD					1566:1568	established CVD	1554:1568	established CVD at baseline	1554:1580	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	7	73	from	baseline	1573:1580	arg1	duration					1530:1537	a longer diabetes duration	1512:1537	a longer diabetes duration	1512:1537	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	6	74	theme	DDD	1216:1218	arg1	increase					1220:1227	each 30-day DDD increase	1204:1227	each 30-day DDD increase in acarbose exposure	1204:1248	RESULTS For each 30-day supply increase in acarbose exposure, the risks of hepatic injury, composite CVD events, and all-cause mortality were significantly lowered by 9% (95% confidence interval: 6-12%), 7% (6-7%) and 7% (7-8%), respectively, while for each 30-day DDD increase in acarbose exposure, the risks for three aforementioned outcomes were significantly reduced by 45% (33-54%), 33% (29-36%) and 35% (32-39%), respectively.
33035600	5	75	theme	use	796:798	arg1	association					772:782	the association	768:782	the association of acarbose use with hepatic, cardiovascular and mortality outcomes	768:850	Time-varying Cox models were applied to evaluate the association of acarbose use with hepatic, cardiovascular and mortality outcomes, with adjustment for patients' demographics, comorbidities, diabetes severity, and co-medications.
33035600	0	76	theme	type	52:55	arg1	diabetes					59:66	type 2 diabetes	52:66	type 2 diabetes	52:66	Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.
33035600	7	77	from	apparent	1461:1468	arg1	analyses					1396:1403	subgroup analyses	1387:1403	subgroup analyses	1387:1403	In subgroup analyses, the favorable study outcomes of acarbose use were more apparent among patients with more severe diabetes, a longer diabetes duration, or absence of established CVD at baseline.
33035600	4	78	theme	30-day	629:634	arg1	drug					636:639	the 30-day drug's	625:641	the 30-day drug's supplies	625:650	The use of acarbose was quantified as the numbers of the 30-day drug's supplies and dosages (measured by defined daily doses; DDDs), respectively.
33035600	8	79	contain	have	1649:1652	arg2	safety					1681:1686	hepatic and cardiovascular safety	1654:1686	hepatic and cardiovascular safety	1654:1686	CONCLUSION Acarbose used in real-world T2D patients with ESRD may have hepatic and cardiovascular safety.
33035600	8	79	contain	have	1649:1652	arg1	CONCLUSION					1583:1592	CONCLUSION Acarbose	1583:1601	CONCLUSION Acarbose used in real-world T2D patients with ESRD	1583:1643	CONCLUSION Acarbose used in real-world T2D patients with ESRD may have hepatic and cardiovascular safety.
34121258	4	0	theme	0.11	833:836	arg1	±					831:831	±	831:831	±	831:831	The radial support of the 4D-printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent.
34121258	3	1	dep	structure	552:560	arg1	the					531:533	the	531:533	the	531:533	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	5	2	theme	endothelial	999:1009	arg1	cells					1011:1015	human umbilical vein endothelial cells	978:1015	human umbilical vein endothelial cells	978:1015	The cell adhesion and proliferation results show a good biocompatibility of the stent with human umbilical vein endothelial cells.
34121258	5	3	with	biocompatibility	943:958	arg1	cells					1011:1015	human umbilical vein endothelial cells	978:1015	human umbilical vein endothelial cells	978:1015	The cell adhesion and proliferation results show a good biocompatibility of the stent with human umbilical vein endothelial cells.
34121258	4	4	theme	0.56	826:829	arg1	±					831:831	±	831:831	±	831:831	The radial support of the 4D-printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent.
34121258	1	5	theme	good	164:167	arg1	biocompatibility					169:184	good biocompatibility	164:184	good biocompatibility	164:184	The 4D-printing technology is applied to fabricate a shape memory peripheral stent with good biocompatibility, which sustains long-term drug release.
34121258	7	6	theme	new	1276:1278	arg1	strategy					1280:1287	a new strategy	1274:1287	a new strategy to solve the urgent need of small-diameter scaffolds to treat critical limb ischemia	1274:1372	This study provides a new strategy to solve the urgent need of small-diameter scaffolds to treat critical limb ischemia.
34121258	6	7	theme	long-term	1235:1243	arg1	release					1245:1251	long-term release	1235:1251	long-term release	1235:1251	Due to the presence of βCD, the wettability and biocompatibility of the materials are improved, and the sustained paclitaxel release based on the host-guest complexion shows the potential of the drug-loaded stent for long-term release.
34121258	3	8	theme	sufficient	673:682	arg1	elasticity					684:693	sufficient elasticity	673:693	sufficient elasticity	673:693	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	6	9	theme	stent	1225:1229	arg1	potential					1196:1204	the potential	1192:1204	the potential of the drug-loaded stent for long-term release	1192:1251	Due to the presence of βCD, the wettability and biocompatibility of the materials are improved, and the sustained paclitaxel release based on the host-guest complexion shows the potential of the drug-loaded stent for long-term release.
34121258	3	10	theme	chemical	566:573	arg1	nature					575:580	chemical nature	566:580	chemical nature	566:580	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	2	11	theme	ε-caprolactone	295:308	arg1	polymerization					277:290	ring opening polymerization	264:290	ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD)	264:345	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	3	12	theme	structure	552:560	arg1	feature					520:526	the feature	516:526	the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD	516:614	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	1	13	with	peripheral stent	142:157	arg1	biocompatibility					169:184	good biocompatibility	164:184	good biocompatibility	164:184	The 4D-printing technology is applied to fabricate a shape memory peripheral stent with good biocompatibility, which sustains long-term drug release.
34121258	6	14	theme	drug-loaded	1213:1223	arg1	stent					1225:1229	the drug-loaded stent	1209:1229	the drug-loaded stent	1209:1229	Due to the presence of βCD, the wettability and biocompatibility of the materials are improved, and the sustained paclitaxel release based on the host-guest complexion shows the potential of the drug-loaded stent for long-term release.
34121258	6	15	theme	βCD	1041:1043	arg1	presence					1029:1036	the presence	1025:1036	the presence of βCD	1025:1043	Due to the presence of βCD, the wettability and biocompatibility of the materials are improved, and the sustained paclitaxel release based on the host-guest complexion shows the potential of the drug-loaded stent for long-term release.
34121258	2	16	theme	β-cyclodextrin	326:339	arg1	-OH					319:321	the -OH	315:321	the -OH of β-cyclodextrin (βCD)	315:345	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	4	17	theme	stent	817:821	arg1	support					791:797	The radial support	780:797	The radial support of the 4D-printed stent	780:821	The radial support of the 4D-printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent.
34121258	4	17	theme	stent	817:821	arg1	N					838:838	N	838:838	N	838:838	The radial support of the 4D-printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent.
34121258	4	17	theme	stent	817:821	arg1	equivalent					847:856	equivalent	847:856	equivalent	847:856	The radial support of the 4D-printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent.
34121258	2	18	theme	acrylate	397:404	arg1	endgroup					406:413	acrylate endgroup	397:413	acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL	397:499	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	4	19	theme	radial	784:789	arg1	support					791:797	The radial support	780:797	The radial support of the 4D-printed stent	780:821	The radial support of the 4D-printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent.
34121258	4	19	theme	radial	784:789	arg1	N					838:838	N	838:838	N	838:838	The radial support of the 4D-printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent.
34121258	4	19	theme	radial	784:789	arg1	equivalent					847:856	equivalent	847:856	equivalent	847:856	The radial support of the 4D-printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent.
34121258	3	20	theme	bursting	699:706	arg1	pressure					708:715	bursting pressure	699:715	bursting pressure	699:715	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	4	21	theme	4D-printed	806:815	arg1	stent					817:821	the 4D-printed stent	802:821	the 4D-printed stent	802:821	The radial support of the 4D-printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent.
34121258	6	22	theme	materials	1090:1098	arg1	biocompatibility					1066:1081	biocompatibility	1066:1081	biocompatibility	1066:1081	Due to the presence of βCD, the wettability and biocompatibility of the materials are improved, and the sustained paclitaxel release based on the host-guest complexion shows the potential of the drug-loaded stent for long-term release.
34121258	6	22	theme	materials	1090:1098	arg1	wettability					1050:1060	wettability	1050:1060	wettability	1050:1060	Due to the presence of βCD, the wettability and biocompatibility of the materials are improved, and the sustained paclitaxel release based on the host-guest complexion shows the potential of the drug-loaded stent for long-term release.
34121258	2	23	theme	opening	269:275	arg1	polymerization					277:290	ring opening polymerization	264:290	ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD)	264:345	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	7	24	theme	critical	1351:1358	arg1	ischemia					1365:1372	critical limb ischemia	1351:1372	critical limb ischemia	1351:1372	This study provides a new strategy to solve the urgent need of small-diameter scaffolds to treat critical limb ischemia.
34121258	3	25	from	comparable	728:737	arg1	body					774:777	human body	768:777	human body	768:777	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	1	26	theme	4D-printing	80:90	arg1	technology					92:101	The 4D-printing technology	76:101	The 4D-printing technology	76:101	The 4D-printing technology is applied to fabricate a shape memory peripheral stent with good biocompatibility, which sustains long-term drug release.
34121258	0	27	theme	4D	0:1	arg1	Printing					3:10	4D Printing	0:10	4D Printing of Shape Memory Vascular Stent	0:41	4D Printing of Shape Memory Vascular Stent Based on βCD-g-Polycaprolactone.
34121258	3	28	with	comparable	728:737	arg1	vein					760:763	great saphenous vein	744:763	great saphenous vein	744:763	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	5	29	theme	vein	994:997	arg1	cells					1011:1015	human umbilical vein endothelial cells	978:1015	human umbilical vein endothelial cells	978:1015	The cell adhesion and proliferation results show a good biocompatibility of the stent with human umbilical vein endothelial cells.
34121258	2	30	mod	modified	383:390	arg1	s-PCL					374:378	then the s-PCL	365:378	then the s-PCL	365:378	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	2	30	mod	modified	383:390	arg3	endgroup					406:413	acrylate endgroup	397:413	acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL	397:499	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	0	31	theme	Shape	15:19	arg1	Stent					37:41	Shape Memory Vascular Stent	15:41	Shape Memory Vascular Stent	15:41	4D Printing of Shape Memory Vascular Stent Based on βCD-g-Polycaprolactone.
34121258	7	32	theme	limb	1360:1363	arg1	ischemia					1365:1372	critical limb ischemia	1351:1372	critical limb ischemia	1351:1372	This study provides a new strategy to solve the urgent need of small-diameter scaffolds to treat critical limb ischemia.
34121258	4	33	theme	commercial	869:878	arg1	stent					880:884	commercial stent	869:884	commercial stent	869:884	The radial support of the 4D-printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent.
34121258	5	34	theme	umbilical	984:992	arg1	cells					1011:1015	human umbilical vein endothelial cells	978:1015	human umbilical vein endothelial cells	978:1015	The cell adhesion and proliferation results show a good biocompatibility of the stent with human umbilical vein endothelial cells.
34121258	3	35	theme	high	535:538	arg1	structure					552:560	high crosslinked structure	535:560	high crosslinked structure	535:560	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	7	36	theme	small-diameter	1317:1330	arg1	scaffolds					1332:1340	small-diameter scaffolds	1317:1340	small-diameter scaffolds	1317:1340	This study provides a new strategy to solve the urgent need of small-diameter scaffolds to treat critical limb ischemia.
34121258	1	37	theme	long-term	202:210	arg1	release					217:223	long-term drug release	202:223	long-term drug release	202:223	The 4D-printing technology is applied to fabricate a shape memory peripheral stent with good biocompatibility, which sustains long-term drug release.
34121258	5	38	theme	cell	891:894	arg1	adhesion					896:903	cell adhesion	891:903	cell adhesion	891:903	The cell adhesion and proliferation results show a good biocompatibility of the stent with human umbilical vein endothelial cells.
34121258	6	39	theme	sustained	1122:1130	arg1	release					1143:1149	the sustained paclitaxel release	1118:1149	the sustained paclitaxel release based on the host-guest complexion	1118:1184	Due to the presence of βCD, the wettability and biocompatibility of the materials are improved, and the sustained paclitaxel release based on the host-guest complexion shows the potential of the drug-loaded stent for long-term release.
34121258	3	40	theme	crosslinked	540:550	arg1	structure					552:560	high crosslinked structure	535:560	high crosslinked structure	535:560	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	5	41	theme	human	978:982	arg1	cells					1011:1015	human umbilical vein endothelial cells	978:1015	human umbilical vein endothelial cells	978:1015	The cell adhesion and proliferation results show a good biocompatibility of the stent with human umbilical vein endothelial cells.
34121258	1	42	theme	drug	212:215	arg1	release					217:223	long-term drug release	202:223	long-term drug release	202:223	The 4D-printing technology is applied to fabricate a shape memory peripheral stent with good biocompatibility, which sustains long-term drug release.
34121258	0	43	theme	Vascular	28:35	arg1	Stent					37:41	Shape Memory Vascular Stent	15:41	Shape Memory Vascular Stent	15:41	4D Printing of Shape Memory Vascular Stent Based on βCD-g-Polycaprolactone.
34121258	6	44	theme	host-guest	1164:1173	arg1	complexion					1175:1184	the host-guest complexion	1160:1184	the host-guest complexion	1160:1184	Due to the presence of βCD, the wettability and biocompatibility of the materials are improved, and the sustained paclitaxel release based on the host-guest complexion shows the potential of the drug-loaded stent for long-term release.
34121258	5	45	theme	stent	967:971	arg1	biocompatibility					943:958	a good biocompatibility	936:958	a good biocompatibility of the stent with human umbilical vein endothelial cells	936:1015	The cell adhesion and proliferation results show a good biocompatibility of the stent with human umbilical vein endothelial cells.
34121258	0	46	theme	Memory	21:26	arg1	Stent					37:41	Shape Memory Vascular Stent	15:41	Shape Memory Vascular Stent	15:41	4D Printing of Shape Memory Vascular Stent Based on βCD-g-Polycaprolactone.
34121258	4	47	dep	N	838:838	arg1	±					831:831	±	831:831	±	831:831	The radial support of the 4D-printed stent is 0.56 ± 0.11 N and is equivalent to that of commercial stent.
34121258	3	48	theme	βCD	612:614	arg1	structure					552:560	high crosslinked structure	535:560	high crosslinked structure	535:560	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	3	48	theme	βCD	612:614	arg1	nature					575:580	chemical nature	566:580	chemical nature	566:580	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	2	49	theme	polymer	235:241	arg1	initiator					350:358	initiator	350:358	initiator	350:358	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	2	49	theme	polymer	235:241	arg1	s-PCL					243:247	The star polymer s-PCL	226:247	The star polymer s-PCL	226:247	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	6	50	dep	wettability	1050:1060	arg1	the					1046:1048	the	1046:1048	the	1046:1048	Due to the presence of βCD, the wettability and biocompatibility of the materials are improved, and the sustained paclitaxel release based on the host-guest complexion shows the potential of the drug-loaded stent for long-term release.
34121258	2	51	theme	UV	453:454	arg1	light					456:460	UV light	453:460	UV light	453:460	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	3	52	link	crosslinked	540:550	arg1	structure					552:560	high crosslinked structure	535:560	high crosslinked structure	535:560	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	2	53	theme	star	230:233	arg1	initiator					350:358	initiator	350:358	initiator	350:358	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	2	53	theme	star	230:233	arg1	s-PCL					243:247	The star polymer s-PCL	226:247	The star polymer s-PCL	226:247	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	0	54	theme	Stent	37:41	arg1	Printing					3:10	4D Printing	0:10	4D Printing of Shape Memory Vascular Stent	0:41	4D Printing of Shape Memory Vascular Stent Based on βCD-g-Polycaprolactone.
34121258	3	55	theme	great	744:748	arg1	vein					760:763	great saphenous vein	744:763	great saphenous vein	744:763	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	3	56	from	body	774:777	arg1	comparable					728:737	comparable	728:737	comparable	728:737	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	3	57	theme	tensile	652:658	arg1	strength					660:667	appropriate tensile strength	640:667	appropriate tensile strength	640:667	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	3	58	theme	nature	575:580	arg1	feature					520:526	the feature	516:526	the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD	516:614	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	3	59	theme	saphenous	750:758	arg1	vein					760:763	great saphenous vein	744:763	great saphenous vein	744:763	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	5	60	theme	good	938:941	arg1	biocompatibility					943:958	a good biocompatibility	936:958	a good biocompatibility of the stent with human umbilical vein endothelial cells	936:1015	The cell adhesion and proliferation results show a good biocompatibility of the stent with human umbilical vein endothelial cells.
34121258	2	61	theme	ring	264:267	arg1	opening					269:275	ring opening	264:275	ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD)	264:345	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	3	62	theme	polycaprolactone	585:600	arg1	structure					552:560	high crosslinked structure	535:560	high crosslinked structure	535:560	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	3	62	theme	polycaprolactone	585:600	arg1	nature					575:580	chemical nature	566:580	chemical nature	566:580	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	5	63	theme	adhesion	896:903	arg1	results					923:929	The cell adhesion and proliferation results	887:929	The cell adhesion and proliferation results	887:929	The cell adhesion and proliferation results show a good biocompatibility of the stent with human umbilical vein endothelial cells.
34121258	2	64	with	polymerization	277:290	arg1	-OH					319:321	the -OH	315:321	the -OH of β-cyclodextrin (βCD)	315:345	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	5	65	theme	proliferation	909:921	arg1	results					923:929	The cell adhesion and proliferation results	887:929	The cell adhesion and proliferation results	887:929	The cell adhesion and proliferation results show a good biocompatibility of the stent with human umbilical vein endothelial cells.
34121258	1	66	theme	shape	129:133	arg1	peripheral stent					142:157	a shape memory peripheral stent	127:157	a shape memory peripheral stent	127:157	The 4D-printing technology is applied to fabricate a shape memory peripheral stent with good biocompatibility, which sustains long-term drug release.
34121258	2	67	theme	network	487:493	arg1	c-PCL					495:499	the crosslinking network c-PCL	470:499	the crosslinking network c-PCL	470:499	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	3	68	theme	appropriate	640:650	arg1	strength					660:667	appropriate tensile strength	640:667	appropriate tensile strength	640:667	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	1	69	theme	memory	135:140	arg1	peripheral stent					142:157	a shape memory peripheral stent	127:157	a shape memory peripheral stent	127:157	The 4D-printing technology is applied to fabricate a shape memory peripheral stent with good biocompatibility, which sustains long-term drug release.
34121258	3	70	theme	human	768:772	arg1	body					774:777	human body	768:777	human body	768:777	Attributed to the feature of the high crosslinked structure and chemical nature of polycaprolactone (PCL) and βCD, the composite exhibits appropriate tensile strength and sufficient elasticity and bursting pressure, and it is comparable with great saphenous vein in human body.
34121258	2	71	theme	crosslinking	474:485	arg1	c-PCL					495:499	the crosslinking network c-PCL	470:499	the crosslinking network c-PCL	470:499	The star polymer s-PCL is prepared by ring opening polymerization of ε-caprolactone with the -OH of β-cyclodextrin (βCD) as initiator, and then the s-PCL is modified with acrylate endgroup which allows the polymerization under UV light to form the crosslinking network c-PCL.
34121258	7	72	theme	urgent	1302:1307	arg1	need					1309:1312	the urgent need	1298:1312	the urgent need of small-diameter scaffolds to treat critical limb ischemia	1298:1372	This study provides a new strategy to solve the urgent need of small-diameter scaffolds to treat critical limb ischemia.
34121258	6	73	theme	paclitaxel	1132:1141	arg1	release					1143:1149	the sustained paclitaxel release	1118:1149	the sustained paclitaxel release based on the host-guest complexion	1118:1184	Due to the presence of βCD, the wettability and biocompatibility of the materials are improved, and the sustained paclitaxel release based on the host-guest complexion shows the potential of the drug-loaded stent for long-term release.
34121258	7	74	theme	scaffolds	1332:1340	arg1	need					1309:1312	the urgent need	1298:1312	the urgent need of small-diameter scaffolds to treat critical limb ischemia	1298:1372	This study provides a new strategy to solve the urgent need of small-diameter scaffolds to treat critical limb ischemia.
33107851	6	0	theme	UV	1202:1203	arg1	irradiation					1205:1215	UV irradiation	1202:1215	UV irradiation	1202:1215	Chitosan/TiO2(P25) was used for the removal of TC by photocatalysis under UV irradiation.
33107851	5	1	theme	chemical	996:1003	arg1	structure					1005:1013	the chemical structure	992:1013	the chemical structure of TiO2(P25)	992:1026	XRD, FTIR, DRS and SEM characterization indicated that TiO2(P25) was successfully immobilized on chitosan film, the chemical structure of TiO2(P25) did not change after the immobilization and the TiO2(P25) was uniformly dispersed in the composite.
33107851	8	2	theme	TiO2	1413:1416	arg1	g					1408:1408	0.12 g	1403:1408	0.12 g of TiO2(P25)	1403:1421	An 87% removal efficiency of TC was obtained with 0.12 g of TiO2(P25) and TC removal was significantly enhanced by the agitation of the solution.
33107851	7	3	theme	parameters	1245:1254	arg1	effects					1222:1228	The effects	1218:1228	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration	1218:1332	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	1	4	theme	TiO2	226:229	arg1	elimination					211:221	the elimination	207:221	the elimination of TiO2(P25) suspended in the treated water	207:265	TiO2(P25) has been widely used to treat wastewater; however, the elimination of TiO2(P25) suspended in the treated water causes running costs and induces secondary pollution, which greatly restricts its practical applications.
33107851	4	5	theme	infrared	666:673	arg1	spectrometry					675:686	infrared spectrometry	666:686	infrared spectrometry (FTIR)	666:693	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	4	5	theme	infrared	666:673	arg1	FTIR					689:692	FTIR	689:692	FTIR	689:692	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	1	6	theme	secondary	300:308	arg1	pollution					310:318	secondary pollution	300:318	secondary pollution	300:318	TiO2(P25) has been widely used to treat wastewater; however, the elimination of TiO2(P25) suspended in the treated water causes running costs and induces secondary pollution, which greatly restricts its practical applications.
33107851	7	7	theme	agitation	1285:1293	arg1	speed					1295:1299	agitation speed	1285:1299	agitation speed	1285:1299	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	9	8	theme	photocatalytic	1633:1646	arg1	reactions					1648:1656	the photocatalytic reactions	1629:1656	the photocatalytic reactions	1629:1656	The TC removal efficiency decreased from 72 to 44% when TC concentration increased from 30 to 40 mg/L after 60 min reaction time, the photocatalytic reactions followed the pseudo-second-order kinetic.
33107851	6	9	theme	TC	1175:1176	arg1	removal					1164:1170	the removal	1160:1170	the removal of TC by photocatalysis under UV irradiation	1160:1215	Chitosan/TiO2(P25) was used for the removal of TC by photocatalysis under UV irradiation.
33107851	4	10	theme	UV-Vis	696:701	arg1	spectra					723:729	UV-Vis diffuse reflectance spectra	696:729	UV-Vis diffuse reflectance spectra (DRS)	696:735	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	4	10	theme	UV-Vis	696:701	arg1	DRS					732:734	DRS	732:734	DRS	732:734	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	2	11	theme	various	452:458	arg1	substrates					460:469	various substrates	452:469	various substrates	452:469	Consequently, several methods have been implemented to immobilize TiO2(P25) on various substrates.
33107851	4	12	theme	electron	750:757	arg1	SEM					771:773	SEM	771:773	SEM	771:773	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	4	12	theme	electron	750:757	arg1	microscopy					759:768	scanning electron microscopy	741:768	scanning electron microscopy (SEM)	741:774	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	9	13	dep	40	1593:1594	arg1	to					1590:1591	to	1590:1591	to	1590:1591	The TC removal efficiency decreased from 72 to 44% when TC concentration increased from 30 to 40 mg/L after 60 min reaction time, the photocatalytic reactions followed the pseudo-second-order kinetic.
33107851	9	14	theme	TC	1555:1556	arg1	concentration					1558:1570	TC concentration	1555:1570	TC concentration	1555:1570	The TC removal efficiency decreased from 72 to 44% when TC concentration increased from 30 to 40 mg/L after 60 min reaction time, the photocatalytic reactions followed the pseudo-second-order kinetic.
33107851	4	15	theme	prepared	581:588	arg1	catalyst					590:597	The prepared catalyst	577:597	The prepared catalyst	577:597	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	0	16	theme	hydrochloride	13:25	arg1	degradation					27:37	Tetracycline hydrochloride degradation	0:37	Tetracycline hydrochloride degradation by heterogeneous photocatalysis using TiO2(P25)	0:85	Tetracycline hydrochloride degradation by heterogeneous photocatalysis using TiO2(P25) immobilized in biopolymer (chitosan) under UV irradiation.
33107851	7	17	theme	TiO2	1274:1277	arg1	P25					1279:1281	P25	1279:1281	P25	1279:1281	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	7	17	theme	TiO2	1274:1277	arg1	speed					1295:1299	agitation speed	1285:1299	agitation speed	1285:1299	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	7	17	theme	TiO2	1274:1277	arg1	TiO2					1274:1277	TiO2	1274:1277	TiO2	1274:1277	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	7	17	theme	TiO2	1274:1277	arg1	concentration					1320:1332	the initial TC concentration	1305:1332	the initial TC concentration	1305:1332	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	7	17	theme	TiO2	1274:1277	arg1	amount					1264:1269	amount	1264:1269	amount of TiO2(P25)	1264:1282	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	3	18	theme	TiO2	515:518	arg1	immobilization					497:510	the immobilization	493:510	the immobilization of TiO2(P25) in chitosan film	493:540	This work deals with the immobilization of TiO2(P25) in chitosan film by using the cross-linking method.
33107851	0	19	theme	Tetracycline	0:11	arg1	degradation					27:37	Tetracycline hydrochloride degradation	0:37	Tetracycline hydrochloride degradation by heterogeneous photocatalysis using TiO2(P25)	0:85	Tetracycline hydrochloride degradation by heterogeneous photocatalysis using TiO2(P25) immobilized in biopolymer (chitosan) under UV irradiation.
33107851	8	20	theme	87	1356:1357	arg1	%					1358:1358	%	1358:1358	%	1358:1358	An 87% removal efficiency of TC was obtained with 0.12 g of TiO2(P25) and TC removal was significantly enhanced by the agitation of the solution.
33107851	6	21	used	used	1151:1154	arg2	Chitosan/TiO2					1128:1140	Chitosan/TiO2	1128:1140	Chitosan/TiO2(P25)	1128:1145	Chitosan/TiO2(P25) was used for the removal of TC by photocatalysis under UV irradiation.
33107851	6	21	used	used	1151:1154	arg2	P25					1142:1144	P25	1142:1144	P25	1142:1144	Chitosan/TiO2(P25) was used for the removal of TC by photocatalysis under UV irradiation.
33107851	7	22	theme	operational	1233:1243	arg1	TiO2					1274:1277	TiO2	1274:1277	TiO2	1274:1277	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	7	22	theme	operational	1233:1243	arg1	amount					1264:1269	amount	1264:1269	amount of TiO2(P25)	1264:1282	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	7	22	theme	operational	1233:1243	arg1	concentration					1320:1332	the initial TC concentration	1305:1332	the initial TC concentration	1305:1332	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	7	22	theme	operational	1233:1243	arg1	parameters					1245:1254	operational parameters	1233:1254	operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration	1233:1332	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	7	22	theme	operational	1233:1243	arg1	speed					1295:1299	agitation speed	1285:1299	agitation speed	1285:1299	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	8	23	theme	solution	1489:1496	arg1	agitation					1472:1480	the agitation	1468:1480	the agitation of the solution	1468:1496	An 87% removal efficiency of TC was obtained with 0.12 g of TiO2(P25) and TC removal was significantly enhanced by the agitation of the solution.
33107851	2	24	theme	several	387:393	arg1	methods					395:401	several methods	387:401	several methods	387:401	Consequently, several methods have been implemented to immobilize TiO2(P25) on various substrates.
33107851	8	25	theme	removal	1360:1366	arg1	efficiency					1368:1377	An 87% removal efficiency	1353:1377	An 87% removal efficiency of TC	1353:1383	An 87% removal efficiency of TC was obtained with 0.12 g of TiO2(P25) and TC removal was significantly enhanced by the agitation of the solution.
33107851	4	26	theme	hydrochloride	820:832	arg1	degradation					839:849	tetracycline hydrochloride (TC) degradation	807:849	tetracycline hydrochloride (TC) degradation	807:849	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	8	27	theme	%	1358:1358	arg1	efficiency					1368:1377	An 87% removal efficiency	1353:1377	An 87% removal efficiency of TC	1353:1383	An 87% removal efficiency of TC was obtained with 0.12 g of TiO2(P25) and TC removal was significantly enhanced by the agitation of the solution.
33107851	9	28	theme	min	1610:1612	arg1	time					1623:1626	60 min reaction time	1607:1626	60 min reaction time	1607:1626	The TC removal efficiency decreased from 72 to 44% when TC concentration increased from 30 to 40 mg/L after 60 min reaction time, the photocatalytic reactions followed the pseudo-second-order kinetic.
33107851	0	29	theme	heterogeneous	42:54	arg1	photocatalysis					56:69	heterogeneous photocatalysis	42:69	heterogeneous photocatalysis using TiO2(P25)	42:85	Tetracycline hydrochloride degradation by heterogeneous photocatalysis using TiO2(P25) immobilized in biopolymer (chitosan) under UV irradiation.
33107851	5	30	theme	TiO2	1018:1021	arg1	structure					1005:1013	the chemical structure	992:1013	the chemical structure of TiO2(P25)	992:1026	XRD, FTIR, DRS and SEM characterization indicated that TiO2(P25) was successfully immobilized on chitosan film, the chemical structure of TiO2(P25) did not change after the immobilization and the TiO2(P25) was uniformly dispersed in the composite.
33107851	0	31	theme	UV	130:131	arg1	irradiation					133:143	UV irradiation	130:143	UV irradiation	130:143	Tetracycline hydrochloride degradation by heterogeneous photocatalysis using TiO2(P25) immobilized in biopolymer (chitosan) under UV irradiation.
33107851	3	32	theme	cross-linking	555:567	arg1	method					569:574	the cross-linking method	551:574	the cross-linking method	551:574	This work deals with the immobilization of TiO2(P25) in chitosan film by using the cross-linking method.
33107851	4	33	theme	UV	857:858	arg1	light					860:864	UV light	857:864	UV light	857:864	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	1	34	theme	treated	253:259	arg1	water					261:265	the treated water	249:265	the treated water	249:265	TiO2(P25) has been widely used to treat wastewater; however, the elimination of TiO2(P25) suspended in the treated water causes running costs and induces secondary pollution, which greatly restricts its practical applications.
33107851	9	35	dep	44	1546:1547	arg1	to					1543:1544	to	1543:1544	to	1543:1544	The TC removal efficiency decreased from 72 to 44% when TC concentration increased from 30 to 40 mg/L after 60 min reaction time, the photocatalytic reactions followed the pseudo-second-order kinetic.
33107851	1	36	theme	practical	349:357	arg1	applications					359:370	its practical applications	345:370	its practical applications	345:370	TiO2(P25) has been widely used to treat wastewater; however, the elimination of TiO2(P25) suspended in the treated water causes running costs and induces secondary pollution, which greatly restricts its practical applications.
33107851	4	37	theme	scanning	741:748	arg1	SEM					771:773	SEM	771:773	SEM	771:773	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	4	37	theme	scanning	741:748	arg1	microscopy					759:768	scanning electron microscopy	741:768	scanning electron microscopy (SEM)	741:774	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	4	38	theme	catalytic	785:793	arg1	activity					795:802	its catalytic activity	781:802	its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light	781:864	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	7	39	theme	initial	1309:1315	arg1	concentration					1320:1332	the initial TC concentration	1305:1332	the initial TC concentration	1305:1332	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	1	40	used	used	172:175	arg2	P25					151:153	P25	151:153	P25	151:153	TiO2(P25) has been widely used to treat wastewater; however, the elimination of TiO2(P25) suspended in the treated water causes running costs and induces secondary pollution, which greatly restricts its practical applications.
33107851	1	40	used	used	172:175	arg2	TiO2					146:149	TiO2	146:149	TiO2(P25)	146:154	TiO2(P25) has been widely used to treat wastewater; however, the elimination of TiO2(P25) suspended in the treated water causes running costs and induces secondary pollution, which greatly restricts its practical applications.
33107851	5	41	dep	XRD	880:882	arg1	characterization					903:918	characterization	903:918	characterization	903:918	XRD, FTIR, DRS and SEM characterization indicated that TiO2(P25) was successfully immobilized on chitosan film, the chemical structure of TiO2(P25) did not change after the immobilization and the TiO2(P25) was uniformly dispersed in the composite.
33107851	3	42	from	immobilization	497:510	arg1	chitosan					528:535	chitosan film	528:540	chitosan film	528:540	This work deals with the immobilization of TiO2(P25) in chitosan film by using the cross-linking method.
33107851	8	43	theme	TC	1382:1383	arg1	efficiency					1368:1377	An 87% removal efficiency	1353:1377	An 87% removal efficiency of TC	1353:1383	An 87% removal efficiency of TC was obtained with 0.12 g of TiO2(P25) and TC removal was significantly enhanced by the agitation of the solution.
33107851	4	44	theme	tetracycline	807:818	arg1	TC					835:836	TC	835:836	TC	835:836	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	4	44	theme	tetracycline	807:818	arg1	hydrochloride					820:832	tetracycline hydrochloride	807:832	tetracycline hydrochloride (TC) degradation	807:849	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	7	45	theme	TC	1317:1318	arg1	concentration					1320:1332	the initial TC concentration	1305:1332	the initial TC concentration	1305:1332	The effects of operational parameters such as amount of TiO2(P25), agitation speed and the initial TC concentration were investigated.
33107851	4	46	theme	reflectance	711:721	arg1	spectra					723:729	UV-Vis diffuse reflectance spectra	696:729	UV-Vis diffuse reflectance spectra (DRS)	696:735	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	4	46	theme	reflectance	711:721	arg1	DRS					732:734	DRS	732:734	DRS	732:734	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	4	47	dep	Fourier	648:654	arg1	transform					656:664	transform	656:664	transform infrared spectrometry (FTIR)	656:693	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	9	48	theme	TC	1503:1504	arg1	efficiency					1514:1523	The TC removal efficiency	1499:1523	The TC removal efficiency	1499:1523	The TC removal efficiency decreased from 72 to 44% when TC concentration increased from 30 to 40 mg/L after 60 min reaction time, the photocatalytic reactions followed the pseudo-second-order kinetic.
33107851	4	49	from	activity	795:802	arg1	degradation					839:849	tetracycline hydrochloride (TC) degradation	807:849	tetracycline hydrochloride (TC) degradation	807:849	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	4	50	theme	diffuse	703:709	arg1	spectra					723:729	UV-Vis diffuse reflectance spectra	696:729	UV-Vis diffuse reflectance spectra (DRS)	696:735	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	4	50	theme	diffuse	703:709	arg1	DRS					732:734	DRS	732:734	DRS	732:734	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	9	51	theme	60	1607:1608	arg1	min					1610:1612	min	1610:1612	min	1610:1612	The TC removal efficiency decreased from 72 to 44% when TC concentration increased from 30 to 40 mg/L after 60 min reaction time, the photocatalytic reactions followed the pseudo-second-order kinetic.
33107851	9	52	theme	removal	1506:1512	arg1	efficiency					1514:1523	The TC removal efficiency	1499:1523	The TC removal efficiency	1499:1523	The TC removal efficiency decreased from 72 to 44% when TC concentration increased from 30 to 40 mg/L after 60 min reaction time, the photocatalytic reactions followed the pseudo-second-order kinetic.
33107851	4	53	theme	X-ray	623:627	arg1	diffraction					629:639	X-ray diffraction	623:639	X-ray diffraction (XRD)	623:645	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	4	53	theme	X-ray	623:627	arg1	XRD					642:644	XRD	642:644	XRD	642:644	The prepared catalyst was characterized using X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), UV-Vis diffuse reflectance spectra (DRS) and scanning electron microscopy (SEM), and its catalytic activity in tetracycline hydrochloride (TC) degradation under UV light was explored.
33107851	8	54	theme	TC	1427:1428	arg1	removal					1430:1436	TC removal	1427:1436	TC removal	1427:1436	An 87% removal efficiency of TC was obtained with 0.12 g of TiO2(P25) and TC removal was significantly enhanced by the agitation of the solution.
33107851	1	55	theme	running	274:280	arg1	costs					282:286	running costs	274:286	running costs	274:286	TiO2(P25) has been widely used to treat wastewater; however, the elimination of TiO2(P25) suspended in the treated water causes running costs and induces secondary pollution, which greatly restricts its practical applications.
33107851	9	56	theme	reaction	1614:1621	arg1	time					1623:1626	60 min reaction time	1607:1626	60 min reaction time	1607:1626	The TC removal efficiency decreased from 72 to 44% when TC concentration increased from 30 to 40 mg/L after 60 min reaction time, the photocatalytic reactions followed the pseudo-second-order kinetic.
33107851	8	57	theme	0.12	1403:1406	arg1	g					1408:1408	0.12 g	1403:1408	0.12 g of TiO2(P25)	1403:1421	An 87% removal efficiency of TC was obtained with 0.12 g of TiO2(P25) and TC removal was significantly enhanced by the agitation of the solution.
34827578	11	0	contain	had	1708:1710	arg1	EIL					1695:1697	EIL	1695:1697	EIL with HHA	1695:1706	EIL with HHA had a lower rate of re-treatment than that with LHA, suggesting a better clinical utility for acute UVFP.
34827578	11	0	contain	had	1708:1710	arg2	rate					1720:1723	a lower rate	1712:1723	a lower rate of re-treatment	1712:1739	EIL with HHA had a lower rate of re-treatment than that with LHA, suggesting a better clinical utility for acute UVFP.
34827578	9	1	theme	LHA	1414:1416	arg1	group					1418:1422	the LHA group	1410:1422	the LHA group	1410:1422	The incidence of the secondary procedures was higher in the LHA group (18.2%) (p = 0.026) than in the HHA group (7.5%).
34827578	3	2	theme	short	480:484	arg1	period					486:491	a short period	478:491	a short period	478:491	However, injected HA might resolve within a short period, so its long-term outcomes and the need for secondary procedures need to be clarified.
34827578	8	3	theme	high-concentrated	1311:1327	arg1	HHA					1333:1335	HHA	1333:1335	HHA	1333:1335	The rate of secondary procedures within the first 12 months was 9.0% (14.1% and 4.3% for low-concentrated HA (LHA) and high-concentrated HA (HHA), respectively).
34827578	8	3	theme	high-concentrated	1311:1327	arg1	HA					1329:1330	high-concentrated HA	1311:1330	high-concentrated HA (HHA)	1311:1336	The rate of secondary procedures within the first 12 months was 9.0% (14.1% and 4.3% for low-concentrated HA (LHA) and high-concentrated HA (HHA), respectively).
34827578	6	4	theme	mean	936:939	arg1	period					951:956	a mean follow-up period	934:956	a mean follow-up period of 25.1 months (95% CI: 22.8-27.4 months)	934:998	RESULTS Ninety-four patients were included for analysis, with a mean follow-up period of 25.1 months (95% CI: 22.8-27.4 months).
34827578	2	5	theme	life	377:380	arg1	quality					366:372	voice and quality	356:372	quality	366:372	Most patients benefit by showing improvement in voice and quality of life and implied reduced need for permanent laryngoplasty.
34827578	2	5	theme	life	377:380	arg1	voice					356:360	voice and quality	356:372	voice	356:360	Most patients benefit by showing improvement in voice and quality of life and implied reduced need for permanent laryngoplasty.
34827578	5	6	theme	HA	846:847	arg1	factors					692:698	The factors	688:698	The factors that may associate with the prognosis including voice performance and laryngeal configuration at presentation, the cause of UVFP,	688:828	The factors that may associate with the prognosis including voice performance and laryngeal configuration at presentation, the cause of UVFP, and the type of HA for EIL were analyzed.
34827578	5	6	theme	HA	846:847	arg1	type					838:841	the type	834:841	the type of HA for EIL	834:855	The factors that may associate with the prognosis including voice performance and laryngeal configuration at presentation, the cause of UVFP, and the type of HA for EIL were analyzed.
34827578	4	7	from	January	643:649	arg1	UVFP					633:636	acute UVFP	627:636	acute UVFP from January 2015 to December 2018	627:671	METHODS Patients who underwent EIL with HA for acute UVFP from January 2015 to December 2018 were included.
34827578	10	8	theme	resorption	1562:1571	arg1	finding					1587:1593	a finding	1585:1593	a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL	1585:1692	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	10	8	theme	resorption	1562:1571	arg1	time					1573:1576	the resorption time	1558:1576	the resorption time of HA	1558:1582	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	0	9	theme	Concentration	97:109	arg1	Matter					111:116	Concentration Matter	97:116	Concentration Matter	97:116	Long-Lasting Effect after Single Hyaluronate Injection for Unilateral Vocal Fold Paralysis: Does Concentration Matter?
34827578	7	10	theme	HA	1015:1016	arg1	injection					1018:1026	primary HA injection	1007:1026	primary HA injection	1007:1026	After primary HA injection, 22 patients (23.4%) underwent secondary procedures (rate: 13.1% per person-year), and most (63.6%) of the events occurred after one year from the first injection.
34827578	10	11	theme	secondary	1498:1506	arg1	procedures					1508:1517	secondary procedures	1498:1517	secondary procedures	1498:1517	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	5	12	theme	laryngeal	770:778	arg1	configuration					780:792	laryngeal configuration	770:792	laryngeal configuration	770:792	The factors that may associate with the prognosis including voice performance and laryngeal configuration at presentation, the cause of UVFP, and the type of HA for EIL were analyzed.
34827578	7	13	dep	procedures	1069:1078	arg1	%					1091:1091	rate: 13.1%	1081:1091	rate: 13.1%	1081:1091	After primary HA injection, 22 patients (23.4%) underwent secondary procedures (rate: 13.1% per person-year), and most (63.6%) of the events occurred after one year from the first injection.
34827578	9	14	dep	higher	1400:1405	arg1	=					1435:1435	=	1435:1435	=	1435:1435	The incidence of the secondary procedures was higher in the LHA group (18.2%) (p = 0.026) than in the HHA group (7.5%).
34827578	9	14	dep	higher	1400:1405	arg1	%					1429:1429	18.2%	1425:1429	18.2%	1425:1429	The incidence of the secondary procedures was higher in the LHA group (18.2%) (p = 0.026) than in the HHA group (7.5%).
34827578	1	15	theme	acute	262:266	arg1	UVFP					301:304	UVFP	301:304	UVFP	301:304	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	15	theme	acute	262:266	arg1	paralysis					290:298	acute unilateral vocal fold paralysis	262:298	acute unilateral vocal fold paralysis (UVFP)	262:305	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	8	16	dep	%	1259:1259	arg1	%					1266:1266	14.1%	1262:1266	14.1%	1262:1266	The rate of secondary procedures within the first 12 months was 9.0% (14.1% and 4.3% for low-concentrated HA (LHA) and high-concentrated HA (HHA), respectively).
34827578	8	16	dep	%	1259:1259	arg1	%					1275:1275	4.3%	1272:1275	4.3% for low-concentrated HA (LHA) and high-concentrated HA (HHA)	1272:1336	The rate of secondary procedures within the first 12 months was 9.0% (14.1% and 4.3% for low-concentrated HA (LHA) and high-concentrated HA (HHA), respectively).
34827578	4	17	dep	January	643:649	arg1	to					656:657	to	656:657	to	656:657	METHODS Patients who underwent EIL with HA for acute UVFP from January 2015 to December 2018 were included.
34827578	4	17	dep	January	643:649	arg1	December					659:666	December	659:666	December	659:666	METHODS Patients who underwent EIL with HA for acute UVFP from January 2015 to December 2018 were included.
34827578	7	18	from	injection	1181:1189	arg1	year					1161:1164	one year	1157:1164	one year from the first injection	1157:1189	After primary HA injection, 22 patients (23.4%) underwent secondary procedures (rate: 13.1% per person-year), and most (63.6%) of the events occurred after one year from the first injection.
34827578	1	19	theme	hyaluronic	172:181	arg1	HA					189:190	HA	189:190	HA	189:190	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	19	theme	hyaluronic	172:181	arg1	acid					183:186	hyaluronic acid	172:186	hyaluronic acid (HA)	172:191	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	7	20	theme	rate	1081:1084	arg1	%					1091:1091	rate: 13.1%	1081:1091	rate: 13.1%	1081:1091	After primary HA injection, 22 patients (23.4%) underwent secondary procedures (rate: 13.1% per person-year), and most (63.6%) of the events occurred after one year from the first injection.
34827578	10	21	dep	CONCLUSIONS	1474:1484	arg1	lower					1523:1527	lower	1523:1527	lower	1523:1527	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	10	21	dep	CONCLUSIONS	1474:1484	arg1	rate					1490:1493	The rate	1486:1493	The rate of secondary procedures	1486:1517	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	7	22	theme	primary	1007:1013	arg1	injection					1018:1026	primary HA injection	1007:1026	primary HA injection	1007:1026	After primary HA injection, 22 patients (23.4%) underwent secondary procedures (rate: 13.1% per person-year), and most (63.6%) of the events occurred after one year from the first injection.
34827578	2	23	from	improvement	341:351	arg1	quality					366:372	voice and quality	356:372	quality	366:372	Most patients benefit by showing improvement in voice and quality of life and implied reduced need for permanent laryngoplasty.
34827578	2	23	from	improvement	341:351	arg1	voice					356:360	voice and quality	356:372	voice	356:360	Most patients benefit by showing improvement in voice and quality of life and implied reduced need for permanent laryngoplasty.
34827578	3	24	theme	long-term	501:509	arg1	outcomes					511:518	its long-term outcomes	497:518	its long-term outcomes	497:518	However, injected HA might resolve within a short period, so its long-term outcomes and the need for secondary procedures need to be clarified.
34827578	5	25	theme	UVFP	824:827	arg1	presentation					797:808	presentation	797:808	presentation	797:808	The factors that may associate with the prognosis including voice performance and laryngeal configuration at presentation, the cause of UVFP, and the type of HA for EIL were analyzed.
34827578	5	25	theme	UVFP	824:827	arg1	cause					815:819	the cause	811:819	the cause of UVFP	811:827	The factors that may associate with the prognosis including voice performance and laryngeal configuration at presentation, the cause of UVFP, and the type of HA for EIL were analyzed.
34827578	7	26	theme	secondary	1059:1067	arg1	procedures					1069:1078	secondary procedures	1059:1078	secondary procedures (rate: 13.1% per person-year)	1059:1108	After primary HA injection, 22 patients (23.4%) underwent secondary procedures (rate: 13.1% per person-year), and most (63.6%) of the events occurred after one year from the first injection.
34827578	11	27	theme	better	1774:1779	arg1	utility					1790:1796	a better clinical utility	1772:1796	a better clinical utility for acute UVFP	1772:1811	EIL with HHA had a lower rate of re-treatment than that with LHA, suggesting a better clinical utility for acute UVFP.
34827578	10	28	theme	nerve	1646:1650	arg1	recovery					1652:1659	natural nerve recovery	1638:1659	natural nerve recovery	1638:1659	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	0	29	theme	Long-Lasting	0:11	arg1	Effect					13:18	Long-Lasting Effect	0:18	Long-Lasting Effect after Single Hyaluronate Injection for Unilateral Vocal Fold Paralysis:	0:90	Long-Lasting Effect after Single Hyaluronate Injection for Unilateral Vocal Fold Paralysis: Does Concentration Matter?
34827578	1	30	theme	unilateral	268:277	arg1	UVFP					301:304	UVFP	301:304	UVFP	301:304	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	30	theme	unilateral	268:277	arg1	paralysis					290:298	acute unilateral vocal fold paralysis	262:298	acute unilateral vocal fold paralysis (UVFP)	262:305	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	11	31	theme	clinical	1781:1788	arg1	utility					1790:1796	a better clinical utility	1772:1796	a better clinical utility for acute UVFP	1772:1811	EIL with HHA had a lower rate of re-treatment than that with LHA, suggesting a better clinical utility for acute UVFP.
34827578	3	32	theme	secondary	537:545	arg1	procedures					547:556	secondary procedures	537:556	secondary procedures	537:556	However, injected HA might resolve within a short period, so its long-term outcomes and the need for secondary procedures need to be clarified.
34827578	4	33	theme	acute	627:631	arg1	UVFP					633:636	acute UVFP	627:636	acute UVFP from January 2015 to December 2018	627:671	METHODS Patients who underwent EIL with HA for acute UVFP from January 2015 to December 2018 were included.
34827578	2	34	theme	permanent	411:419	arg1	laryngoplasty					421:433	permanent laryngoplasty	411:433	permanent laryngoplasty	411:433	Most patients benefit by showing improvement in voice and quality of life and implied reduced need for permanent laryngoplasty.
34827578	1	35	theme	vocal	279:283	arg1	UVFP					301:304	UVFP	301:304	UVFP	301:304	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	35	theme	vocal	279:283	arg1	paralysis					290:298	acute unilateral vocal fold paralysis	262:298	acute unilateral vocal fold paralysis (UVFP)	262:305	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	9	36	theme	procedures	1385:1394	arg1	higher					1400:1405	higher	1400:1405	higher	1400:1405	The incidence of the secondary procedures was higher in the LHA group (18.2%) (p = 0.026) than in the HHA group (7.5%).
34827578	9	36	theme	procedures	1385:1394	arg1	incidence					1358:1366	The incidence	1354:1366	The incidence of the secondary procedures	1354:1394	The incidence of the secondary procedures was higher in the LHA group (18.2%) (p = 0.026) than in the HHA group (7.5%).
34827578	5	37	theme	voice	748:752	arg1	performance					754:764	voice performance	748:764	voice performance	748:764	The factors that may associate with the prognosis including voice performance and laryngeal configuration at presentation, the cause of UVFP, and the type of HA for EIL were analyzed.
34827578	3	38	theme	injected	445:452	arg1	HA					454:455	injected HA	445:455	injected HA	445:455	However, injected HA might resolve within a short period, so its long-term outcomes and the need for secondary procedures need to be clarified.
34827578	6	39	dep	CI	978:979	arg1	months					992:997	22.8-27.4 months	982:997	22.8-27.4 months	982:997	RESULTS Ninety-four patients were included for analysis, with a mean follow-up period of 25.1 months (95% CI: 22.8-27.4 months).
34827578	1	40	theme	fold	285:288	arg1	UVFP					301:304	UVFP	301:304	UVFP	301:304	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	40	theme	fold	285:288	arg1	paralysis					290:298	acute unilateral vocal fold paralysis	262:298	acute unilateral vocal fold paralysis (UVFP)	262:305	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	6	41	dep	RESULTS	872:878	arg1	patients					892:899	Ninety-four patients	880:899	RESULTS Ninety-four patients	872:899	RESULTS Ninety-four patients were included for analysis, with a mean follow-up period of 25.1 months (95% CI: 22.8-27.4 months).
34827578	8	42	theme	secondary	1204:1212	arg1	procedures					1214:1223	secondary procedures	1204:1223	secondary procedures	1204:1223	The rate of secondary procedures within the first 12 months was 9.0% (14.1% and 4.3% for low-concentrated HA (LHA) and high-concentrated HA (HHA), respectively).
34827578	2	43	theme	reduced	394:400	arg1	need					402:405	reduced need	394:405	reduced need for permanent laryngoplasty	394:433	Most patients benefit by showing improvement in voice and quality of life and implied reduced need for permanent laryngoplasty.
34827578	10	44	theme	HA	1581:1582	arg1	finding					1587:1593	a finding	1585:1593	a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL	1585:1692	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	10	44	theme	HA	1581:1582	arg1	time					1573:1576	the resorption time	1558:1576	the resorption time of HA	1558:1582	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	11	45	theme	acute	1802:1806	arg1	UVFP					1808:1811	acute UVFP	1802:1811	acute UVFP	1802:1811	EIL with HHA had a lower rate of re-treatment than that with LHA, suggesting a better clinical utility for acute UVFP.
34827578	0	46	theme	Hyaluronate	33:43	arg1	Injection					45:53	Single Hyaluronate Injection	26:53	Single Hyaluronate Injection	26:53	Long-Lasting Effect after Single Hyaluronate Injection for Unilateral Vocal Fold Paralysis: Does Concentration Matter?
34827578	10	47	theme	long-lasting	1667:1678	arg1	effect					1680:1685	a long-lasting effect	1665:1685	a long-lasting effect of EIL	1665:1692	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	11	48	theme	lower	1714:1718	arg1	rate					1720:1723	a lower rate	1712:1723	a lower rate of re-treatment	1712:1739	EIL with HHA had a lower rate of re-treatment than that with LHA, suggesting a better clinical utility for acute UVFP.
34827578	0	49	theme	Single	26:31	arg1	Injection					45:53	Single Hyaluronate Injection	26:53	Single Hyaluronate Injection	26:53	Long-Lasting Effect after Single Hyaluronate Injection for Unilateral Vocal Fold Paralysis: Does Concentration Matter?
34827578	1	50	theme	effective	199:207	arg1	treatment					209:217	an effective treatment	196:217	an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP)	196:305	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	50	theme	effective	199:207	arg1	laryngoplasty					146:158	BACKGROUND Early injection laryngoplasty	119:158	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA)	119:191	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	0	51	theme	Unilateral	59:68	arg1	Paralysis					81:89	Unilateral Vocal Fold Paralysis	59:89	Unilateral Vocal Fold Paralysis	59:89	Long-Lasting Effect after Single Hyaluronate Injection for Unilateral Vocal Fold Paralysis: Does Concentration Matter?
34827578	6	52	theme	Ninety-four	880:890	arg1	patients					892:899	Ninety-four patients	880:899	RESULTS Ninety-four patients	872:899	RESULTS Ninety-four patients were included for analysis, with a mean follow-up period of 25.1 months (95% CI: 22.8-27.4 months).
34827578	10	53	theme	natural	1638:1644	arg1	recovery					1652:1659	natural nerve recovery	1638:1659	natural nerve recovery	1638:1659	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	9	54	theme	secondary	1375:1383	arg1	procedures					1385:1394	the secondary procedures	1371:1394	the secondary procedures	1371:1394	The incidence of the secondary procedures was higher in the LHA group (18.2%) (p = 0.026) than in the HHA group (7.5%).
34827578	11	55	theme	re-treatment	1728:1739	arg1	rate					1720:1723	a lower rate	1712:1723	a lower rate of re-treatment	1712:1739	EIL with HHA had a lower rate of re-treatment than that with LHA, suggesting a better clinical utility for acute UVFP.
34827578	1	56	theme	BACKGROUND	119:128	arg1	EIL					161:163	EIL	161:163	EIL	161:163	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	56	theme	BACKGROUND	119:128	arg1	treatment					209:217	an effective treatment	196:217	an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP)	196:305	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	56	theme	BACKGROUND	119:128	arg1	laryngoplasty					146:158	BACKGROUND Early injection laryngoplasty	119:158	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA)	119:191	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	57	from	insufficiency	231:243	arg1	patients					248:255	patients	248:255	patients with acute unilateral vocal fold paralysis (UVFP)	248:305	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	8	58	theme	first	1236:1240	arg1	months					1245:1250	the first 12 months	1232:1250	the first 12 months	1232:1250	The rate of secondary procedures within the first 12 months was 9.0% (14.1% and 4.3% for low-concentrated HA (LHA) and high-concentrated HA (HHA), respectively).
34827578	1	59	theme	Early	130:134	arg1	EIL					161:163	EIL	161:163	EIL	161:163	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	59	theme	Early	130:134	arg1	treatment					209:217	an effective treatment	196:217	an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP)	196:305	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	59	theme	Early	130:134	arg1	laryngoplasty					146:158	BACKGROUND Early injection laryngoplasty	119:158	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA)	119:191	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	9	60	theme	HHA	1456:1458	arg1	%					1470:1470	7.5%	1467:1470	7.5%	1467:1470	The incidence of the secondary procedures was higher in the LHA group (18.2%) (p = 0.026) than in the HHA group (7.5%).
34827578	9	60	theme	HHA	1456:1458	arg1	group					1460:1464	the HHA group	1452:1464	the HHA group (7.5%)	1452:1471	The incidence of the secondary procedures was higher in the LHA group (18.2%) (p = 0.026) than in the HHA group (7.5%).
34827578	4	61	with	EIL	611:613	arg1	HA					620:621	HA	620:621	HA	620:621	METHODS Patients who underwent EIL with HA for acute UVFP from January 2015 to December 2018 were included.
34827578	1	62	with	patients	248:255	arg1	UVFP					301:304	UVFP	301:304	UVFP	301:304	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	62	with	patients	248:255	arg1	paralysis					290:298	acute unilateral vocal fold paralysis	262:298	acute unilateral vocal fold paralysis (UVFP)	262:305	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	63	theme	injection	136:144	arg1	EIL					161:163	EIL	161:163	EIL	161:163	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	63	theme	injection	136:144	arg1	treatment					209:217	an effective treatment	196:217	an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP)	196:305	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	1	63	theme	injection	136:144	arg1	laryngoplasty					146:158	BACKGROUND Early injection laryngoplasty	119:158	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA)	119:191	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	8	64	theme	procedures	1214:1223	arg1	rate					1196:1199	The rate	1192:1199	The rate of secondary procedures within the first 12 months	1192:1250	The rate of secondary procedures within the first 12 months was 9.0% (14.1% and 4.3% for low-concentrated HA (LHA) and high-concentrated HA (HHA), respectively).
34827578	8	64	theme	procedures	1214:1223	arg1	%					1259:1259	9.0%	1256:1259	9.0%	1256:1259	The rate of secondary procedures within the first 12 months was 9.0% (14.1% and 4.3% for low-concentrated HA (LHA) and high-concentrated HA (HHA), respectively).
34827578	8	65	theme	low-concentrated	1281:1296	arg1	LHA					1302:1304	LHA	1302:1304	LHA	1302:1304	The rate of secondary procedures within the first 12 months was 9.0% (14.1% and 4.3% for low-concentrated HA (LHA) and high-concentrated HA (HHA), respectively).
34827578	8	65	theme	low-concentrated	1281:1296	arg1	HA					1298:1299	low-concentrated HA	1281:1299	low-concentrated HA (LHA)	1281:1305	The rate of secondary procedures within the first 12 months was 9.0% (14.1% and 4.3% for low-concentrated HA (LHA) and high-concentrated HA (HHA), respectively).
34827578	2	66	theme	Most	308:311	arg1	patients					313:320	Most patients	308:320	Most patients	308:320	Most patients benefit by showing improvement in voice and quality of life and implied reduced need for permanent laryngoplasty.
34827578	10	67	theme	EIL	1690:1692	arg1	effect					1680:1685	a long-lasting effect	1665:1685	a long-lasting effect of EIL	1665:1692	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	10	67	theme	EIL	1690:1692	arg1	recovery					1652:1659	natural nerve recovery	1638:1659	natural nerve recovery	1638:1659	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	0	68	theme	Fold	76:79	arg1	Paralysis					81:89	Unilateral Vocal Fold Paralysis	59:89	Unilateral Vocal Fold Paralysis	59:89	Long-Lasting Effect after Single Hyaluronate Injection for Unilateral Vocal Fold Paralysis: Does Concentration Matter?
34827578	6	69	theme	months	966:971	arg1	period					951:956	a mean follow-up period	934:956	a mean follow-up period of 25.1 months (95% CI: 22.8-27.4 months)	934:998	RESULTS Ninety-four patients were included for analysis, with a mean follow-up period of 25.1 months (95% CI: 22.8-27.4 months).
34827578	7	70	theme	first	1175:1179	arg1	injection					1181:1189	the first injection	1171:1189	the first injection	1171:1189	After primary HA injection, 22 patients (23.4%) underwent secondary procedures (rate: 13.1% per person-year), and most (63.6%) of the events occurred after one year from the first injection.
34827578	6	71	theme	%	976:976	arg1	months					966:971	25.1 months	961:971	25.1 months (95% CI: 22.8-27.4 months)	961:998	RESULTS Ninety-four patients were included for analysis, with a mean follow-up period of 25.1 months (95% CI: 22.8-27.4 months).
34827578	6	71	theme	%	976:976	arg1	CI					978:979	95% CI	974:979	95% CI	974:979	RESULTS Ninety-four patients were included for analysis, with a mean follow-up period of 25.1 months (95% CI: 22.8-27.4 months).
34827578	1	72	theme	glottic	223:229	arg1	insufficiency					231:243	glottic insufficiency	223:243	glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP)	223:305	BACKGROUND Early injection laryngoplasty (EIL) using hyaluronic acid (HA) is an effective treatment for glottic insufficiency in patients with acute unilateral vocal fold paralysis (UVFP).
34827578	0	73	theme	Vocal	70:74	arg1	Paralysis					81:89	Unilateral Vocal Fold Paralysis	59:89	Unilateral Vocal Fold Paralysis	59:89	Long-Lasting Effect after Single Hyaluronate Injection for Unilateral Vocal Fold Paralysis: Does Concentration Matter?
34827578	10	74	theme	procedures	1508:1517	arg1	lower					1523:1527	lower	1523:1527	lower	1523:1527	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	10	74	theme	procedures	1508:1517	arg1	rate					1490:1493	The rate	1486:1493	The rate of secondary procedures	1486:1517	CONCLUSIONS The rate of secondary procedures was lower than the prediction based on the resorption time of HA, a finding that could be partly accounted for by both natural nerve recovery and a long-lasting effect of EIL.
34827578	6	75	theme	follow-up	941:949	arg1	period					951:956	a mean follow-up period	934:956	a mean follow-up period of 25.1 months (95% CI: 22.8-27.4 months)	934:998	RESULTS Ninety-four patients were included for analysis, with a mean follow-up period of 25.1 months (95% CI: 22.8-27.4 months).
34827578	11	76	with	EIL	1695:1697	arg1	HHA					1704:1706	HHA	1704:1706	HHA	1704:1706	EIL with HHA had a lower rate of re-treatment than that with LHA, suggesting a better clinical utility for acute UVFP.
34827578	4	77	theme	METHODS	580:586	arg1	Patients					588:595	METHODS Patients	580:595	METHODS Patients who underwent EIL with HA for acute UVFP from January 2015 to December 2018	580:671	METHODS Patients who underwent EIL with HA for acute UVFP from January 2015 to December 2018 were included.
33960220	7	0	from	hypertension	837:848	arg1	Italy					928:932	Italy	928:932	Italy	928:932	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	2	1	theme	polyphenol	294:303	arg1	contents					318:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents	262:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents	262:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents were evaluated.
33960220	4	2	theme	concentration	512:524	arg1	content					475:481	its modest content	464:481	its modest content of sodium and high potassium concentration	464:524	The mineral elements profile was interesting due to its modest content of sodium and high potassium concentration.
33960220	0	3	theme	Central	81:87	arg1	Italy					102:106	Central and Southern Italy	81:106	Italy	102:106	Nutritional and mineral composition of persimmon fruits (Diospyros kaki L.) from Central and Southern Italy.
33960220	7	4	theme	cultivation	896:906	arg1	hypertension					837:848	hypertension	837:848	hypertension	837:848	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	4	theme	cultivation	896:906	arg1	diseases					860:867	heart diseases	854:867	heart diseases	854:867	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	4	theme	cultivation	896:906	arg1	genuineness					877:887	the genuineness	873:887	the genuineness of its cultivation in Central-Southern Italy	873:932	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	5	from	diseases	860:867	arg1	Italy					928:932	Italy	928:932	Italy	928:932	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	6	theme	heart	854:858	arg1	diseases					860:867	heart diseases	854:867	heart diseases	854:867	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	4	7	theme	mineral	416:422	arg1	interesting					445:455	interesting	445:455	interesting	445:455	The mineral elements profile was interesting due to its modest content of sodium and high potassium concentration.
33960220	4	7	theme	mineral	416:422	arg1	profile					433:439	The mineral elements profile	412:439	The mineral elements profile	412:439	The mineral elements profile was interesting due to its modest content of sodium and high potassium concentration.
33960220	7	8	theme	fruit	789:793	arg1	value					775:779	the nutritional value	759:779	the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy	759:932	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	8	9	dep	[Formula	934:941	arg1	see					944:946	see	944:946	see text	944:951	[Formula: see text].
33960220	0	10	theme	Southern	93:100	arg1	Italy					102:106	Central and Southern Italy	81:106	Italy	102:106	Nutritional and mineral composition of persimmon fruits (Diospyros kaki L.) from Central and Southern Italy.
33960220	1	11	theme	mineral	144:150	arg1	composition					152:162	the nutritional and mineral composition	124:162	the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions	124:245	In this study, the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions was evaluated.
33960220	4	12	theme	elements	424:431	arg1	interesting					445:455	interesting	445:455	interesting	445:455	The mineral elements profile was interesting due to its modest content of sodium and high potassium concentration.
33960220	4	12	theme	elements	424:431	arg1	profile					433:439	The mineral elements profile	412:439	The mineral elements profile	412:439	The mineral elements profile was interesting due to its modest content of sodium and high potassium concentration.
33960220	6	13	theme	gallic	715:720	arg1	acid					722:725	gallic acid	715:725	gallic acid	715:725	The total polyphenol content of the fruits analysed was very variable, interesting for the quantities found both total and gallic acid.
33960220	6	14	theme	fruits	628:633	arg1	interesting					663:673	interesting	663:673	interesting	663:673	The total polyphenol content of the fruits analysed was very variable, interesting for the quantities found both total and gallic acid.
33960220	6	14	theme	fruits	628:633	arg1	variable					653:660	variable	653:660	variable	653:660	The total polyphenol content of the fruits analysed was very variable, interesting for the quantities found both total and gallic acid.
33960220	6	14	theme	fruits	628:633	arg1	content					613:619	The total polyphenol content	592:619	The total polyphenol content of the fruits analysed	592:642	The total polyphenol content of the fruits analysed was very variable, interesting for the quantities found both total and gallic acid.
33960220	7	15	from	Italy	928:932	arg1	hypertension					837:848	hypertension	837:848	hypertension	837:848	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	15	from	Italy	928:932	arg1	diseases					860:867	heart diseases	854:867	heart diseases	854:867	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	15	from	Italy	928:932	arg1	genuineness					877:887	the genuineness	873:887	the genuineness of its cultivation in Central-Southern Italy	873:932	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	0	16	theme	Nutritional	0:10	arg1	composition					24:34	Nutritional and mineral composition	0:34	Nutritional and mineral composition of persimmon fruits (Diospyros kaki L.) from Central and Southern Italy.	0:107	Nutritional and mineral composition of persimmon fruits (Diospyros kaki L.) from Central and Southern Italy.
33960220	1	17	theme	Sicily	232:237	arg1	Campania					202:209	Campania	202:209	Campania	202:209	In this study, the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions was evaluated.
33960220	1	17	theme	Sicily	232:237	arg1	regions					239:245	Sicily regions	232:245	Sicily regions	232:245	In this study, the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions was evaluated.
33960220	5	18	theme	Protein	527:533	arg1	amounts					535:541	Protein amounts	527:541	Protein amounts	527:541	Protein amounts were in line with the quantities for this fruit.
33960220	2	19	theme	fiber	270:274	arg1	contents					318:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents	262:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents	262:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents were evaluated.
33960220	7	20	theme	nutritional	763:773	arg1	value					775:779	the nutritional value	759:779	the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy	759:932	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	4	21	theme	sodium	486:491	arg1	content					475:481	its modest content	464:481	its modest content of sodium and high potassium concentration	464:524	The mineral elements profile was interesting due to its modest content of sodium and high potassium concentration.
33960220	2	22	theme	Dietary	262:268	arg1	fiber					270:274	Dietary fiber	262:274	Dietary fiber	262:274	Dietary fiber, mineral, pectin, polyphenol, and protein contents were evaluated.
33960220	1	23	theme	Diospyros	167:175	arg1	fruits					182:187	Diospyros kaki fruits	167:187	Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions	167:245	In this study, the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions was evaluated.
33960220	0	24	theme	mineral	16:22	arg1	composition					24:34	Nutritional and mineral composition	0:34	Nutritional and mineral composition of persimmon fruits (Diospyros kaki L.) from Central and Southern Italy.	0:107	Nutritional and mineral composition of persimmon fruits (Diospyros kaki L.) from Central and Southern Italy.
33960220	4	25	theme	potassium	502:510	arg1	concentration					512:524	high potassium concentration	497:524	high potassium concentration	497:524	The mineral elements profile was interesting due to its modest content of sodium and high potassium concentration.
33960220	1	26	theme	nutritional	128:138	arg1	composition					152:162	the nutritional and mineral composition	124:162	the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions	124:245	In this study, the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions was evaluated.
33960220	1	27	theme	kaki	177:180	arg1	fruits					182:187	Diospyros kaki fruits	167:187	Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions	167:245	In this study, the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions was evaluated.
33960220	0	28	theme	persimmon	39:47	arg1	L.					72:73	L.	72:73	L.	72:73	Nutritional and mineral composition of persimmon fruits (Diospyros kaki L.) from Central and Southern Italy.
33960220	0	28	theme	persimmon	39:47	arg1	fruits					49:54	persimmon fruits	39:54	persimmon fruits (Diospyros kaki L.)	39:74	Nutritional and mineral composition of persimmon fruits (Diospyros kaki L.) from Central and Southern Italy.
33960220	4	29	theme	high	497:500	arg1	concentration					512:524	high potassium concentration	497:524	high potassium concentration	497:524	The mineral elements profile was interesting due to its modest content of sodium and high potassium concentration.
33960220	1	30	theme	fruits	182:187	arg1	composition					152:162	the nutritional and mineral composition	124:162	the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions	124:245	In this study, the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions was evaluated.
33960220	6	31	theme	polyphenol	602:611	arg1	interesting					663:673	interesting	663:673	interesting	663:673	The total polyphenol content of the fruits analysed was very variable, interesting for the quantities found both total and gallic acid.
33960220	6	31	theme	polyphenol	602:611	arg1	variable					653:660	variable	653:660	variable	653:660	The total polyphenol content of the fruits analysed was very variable, interesting for the quantities found both total and gallic acid.
33960220	6	31	theme	polyphenol	602:611	arg1	content					613:619	The total polyphenol content	592:619	The total polyphenol content of the fruits analysed	592:642	The total polyphenol content of the fruits analysed was very variable, interesting for the quantities found both total and gallic acid.
33960220	3	32	theme	fiber	393:397	arg1	high					356:359	high	356:359	high	356:359	Particularly high are the contents of the dietary fiber and pectins.
33960220	3	32	theme	fiber	393:397	arg1	contents					369:376	the contents	365:376	the contents of the dietary fiber	365:397	Particularly high are the contents of the dietary fiber and pectins.
33960220	3	32	theme	fiber	393:397	arg1	pectins					403:409	pectins	403:409	pectins	403:409	Particularly high are the contents of the dietary fiber and pectins.
33960220	4	33	theme	modest	468:473	arg1	content					475:481	its modest content	464:481	its modest content of sodium and high potassium concentration	464:524	The mineral elements profile was interesting due to its modest content of sodium and high potassium concentration.
33960220	5	34	with	line	551:554	arg1	quantities					565:574	the quantities	561:574	the quantities for this fruit	561:589	Protein amounts were in line with the quantities for this fruit.
33960220	1	35	from	Campania	202:209	arg1	composition					152:162	the nutritional and mineral composition	124:162	the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions	124:245	In this study, the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions was evaluated.
33960220	1	35	from	Campania	202:209	arg1	fruits					182:187	Diospyros kaki fruits	167:187	Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions	167:245	In this study, the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions was evaluated.
33960220	0	36	theme	fruits	49:54	arg1	composition					24:34	Nutritional and mineral composition	0:34	Nutritional and mineral composition of persimmon fruits (Diospyros kaki L.) from Central and Southern Italy.	0:107	Nutritional and mineral composition of persimmon fruits (Diospyros kaki L.) from Central and Southern Italy.
33960220	2	37	theme	pectin	286:291	arg1	contents					318:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents	262:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents	262:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents were evaluated.
33960220	6	38	theme	total	596:600	arg1	interesting					663:673	interesting	663:673	interesting	663:673	The total polyphenol content of the fruits analysed was very variable, interesting for the quantities found both total and gallic acid.
33960220	6	38	theme	total	596:600	arg1	variable					653:660	variable	653:660	variable	653:660	The total polyphenol content of the fruits analysed was very variable, interesting for the quantities found both total and gallic acid.
33960220	6	38	theme	total	596:600	arg1	content					613:619	The total polyphenol content	592:619	The total polyphenol content of the fruits analysed	592:642	The total polyphenol content of the fruits analysed was very variable, interesting for the quantities found both total and gallic acid.
33960220	6	39	dep	variable	653:660	arg1	interesting					663:673	interesting	663:673	interesting	663:673	The total polyphenol content of the fruits analysed was very variable, interesting for the quantities found both total and gallic acid.
33960220	6	39	dep	variable	653:660	arg1	variable					653:660	variable	653:660	variable	653:660	The total polyphenol content of the fruits analysed was very variable, interesting for the quantities found both total and gallic acid.
33960220	6	39	dep	variable	653:660	arg1	content					613:619	The total polyphenol content	592:619	The total polyphenol content of the fruits analysed	592:642	The total polyphenol content of the fruits analysed was very variable, interesting for the quantities found both total and gallic acid.
33960220	1	40	from	composition	152:162	arg1	Campania					202:209	Campania	202:209	Campania	202:209	In this study, the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions was evaluated.
33960220	1	40	from	composition	152:162	arg1	Sardinia					219:226	Sardinia	219:226	Sardinia	219:226	In this study, the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions was evaluated.
33960220	1	40	from	composition	152:162	arg1	regions					239:245	Sicily regions	232:245	Sicily regions	232:245	In this study, the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions was evaluated.
33960220	1	40	from	composition	152:162	arg1	Lazio					212:216	Lazio	212:216	Lazio	212:216	In this study, the nutritional and mineral composition of Diospyros kaki fruits from Apulia, Campania, Lazio, Sardinia and Sicily regions was evaluated.
33960220	2	41	theme	mineral	277:283	arg1	contents					318:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents	262:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents	262:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents were evaluated.
33960220	7	42	theme	special	804:810	arg1	regimens					820:827	special dietary regimens	804:827	special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy	804:932	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	42	theme	special	804:810	arg1	hypertension					837:848	hypertension	837:848	hypertension	837:848	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	42	theme	special	804:810	arg1	diseases					860:867	heart diseases	854:867	heart diseases	854:867	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	42	theme	special	804:810	arg1	genuineness					877:887	the genuineness	873:887	the genuineness of its cultivation in Central-Southern Italy	873:932	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	2	43	theme	protein	310:316	arg1	contents					318:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents	262:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents	262:325	Dietary fiber, mineral, pectin, polyphenol, and protein contents were evaluated.
33960220	3	44	theme	dietary	385:391	arg1	fiber					393:397	the dietary fiber	381:397	the dietary fiber	381:397	Particularly high are the contents of the dietary fiber and pectins.
33960220	7	45	from	cultivation	896:906	arg1	Italy					928:932	Italy	928:932	Italy	928:932	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	46	from	genuineness	877:887	arg1	Italy					928:932	Italy	928:932	Italy	928:932	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	47	theme	dietary	812:818	arg1	regimens					820:827	special dietary regimens	804:827	special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy	804:932	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	47	theme	dietary	812:818	arg1	hypertension					837:848	hypertension	837:848	hypertension	837:848	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	47	theme	dietary	812:818	arg1	diseases					860:867	heart diseases	854:867	heart diseases	854:867	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	7	47	theme	dietary	812:818	arg1	genuineness					877:887	the genuineness	873:887	the genuineness of its cultivation in Central-Southern Italy	873:932	The results obtained confirmed the nutritional value of this fruit even for special dietary regimens such as hypertension and heart diseases and the genuineness of its cultivation in Central-Southern Italy.
33960220	0	48	from	Italy	102:106	arg1	composition					24:34	Nutritional and mineral composition	0:34	Nutritional and mineral composition of persimmon fruits (Diospyros kaki L.) from Central and Southern Italy.	0:107	Nutritional and mineral composition of persimmon fruits (Diospyros kaki L.) from Central and Southern Italy.
34400092	5	0	dep	age	746:748	arg1	26.3 ± 1.9 years					751:766	26.3 ± 1.9 years	751:766	mean age: 26.3 ± 1.9 years	741:766	Controls (n = 22, mean age: 26.3 ± 1.9 years) were imaged once at corresponding time points (t0: n = 11; t1: n = 11).
34400092	3	1	theme	mean	480:483	arg1	age					485:487	mean age	480:487	mean age: 23.9 ± 3.3 years	480:505	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	1	2	theme	training	237:244	arg1	function					215:222	a function	213:222	a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI)	213:340	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	9	3	from	effects	1624:1630	arg1	response					1635:1642	response	1635:1642	response to training	1635:1654	CONCLUSIONS Professional elite-level rowing is transiently associated with significantly higher gagCEST values, which indicate increased lumbar IVD-GAG content and strong remodeling effects in response to training.
34400092	7	4	theme	Linear	1004:1009	arg1	models					1017:1022	Linear mixed models	1004:1022	Linear mixed models	1004:1022	Linear mixed models were set up to assess the influence of cohort and other variables on GAG content.
34400092	1	5	theme	elite	249:253	arg1	athletes					255:262	elite athletes	249:262	elite athletes	249:262	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	1	6	from	controls	280:287	arg1	function					215:222	a function	213:222	a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI)	213:340	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	9	7	from	content	1594:1600	arg1	response					1635:1642	response	1635:1642	response to training	1635:1654	CONCLUSIONS Professional elite-level rowing is transiently associated with significantly higher gagCEST values, which indicate increased lumbar IVD-GAG content and strong remodeling effects in response to training.
34400092	10	8	theme	spine	1772:1776	arg1	target					1805:1810	a potential therapeutic target	1781:1810	a potential therapeutic target in treating back pain	1781:1832	Beyond professional rowing, core-strengthening full-body exercise may help to enhance the resilience of the lumbar spine as a potential therapeutic target in treating back pain.
34400092	10	8	theme	spine	1772:1776	arg1	resilience					1747:1756	the resilience	1743:1756	the resilience of the lumbar spine	1743:1776	Beyond professional rowing, core-strengthening full-body exercise may help to enhance the resilience of the lumbar spine as a potential therapeutic target in treating back pain.
34400092	3	9	theme	3.0 T	534:538	arg1	scanner					544:550	a clinical 3.0 T MRI scanner	523:550	a clinical 3.0 T MRI scanner	523:550	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	5	10	theme	time	803:806	arg1	points					808:813	corresponding time points	789:813	corresponding time points (t0: n = 11; t1: n = 11)	789:838	Controls (n = 22, mean age: 26.3 ± 1.9 years) were imaged once at corresponding time points (t0: n = 11; t1: n = 11).
34400092	6	11	theme	glycosaminoglycan	859:875	arg1	content					883:889	the glycosaminoglycan (GAG) content	855:889	the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195)	855:914	Segment-wise, the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195) was determined using glycosaminoglycan chemical exchange saturation transfer (gagCEST).
34400092	4	12	theme	annual	586:591	arg1	cycle					602:606	the annual training cycle	582:606	the annual training cycle	582:606	ERs were imaged twice during the annual training cycle, i.e., at training intensive preseason preparations (t0) and 6 months later during post-competition recovery (t1).
34400092	1	13	theme	lumbar	191:196	arg1	IVDs					198:201	lumbar IVDs	191:201	lumbar IVDs	191:201	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	9	14	theme	rowing	1479:1484	arg1	Professional					1454:1465	CONCLUSIONS Professional	1442:1465	CONCLUSIONS Professional elite-level rowing	1442:1484	CONCLUSIONS Professional elite-level rowing is transiently associated with significantly higher gagCEST values, which indicate increased lumbar IVD-GAG content and strong remodeling effects in response to training.
34400092	1	15	from	training	237:244	arg1	athletes					255:262	elite athletes	249:262	elite athletes	249:262	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	1	15	from	training	237:244	arg1	controls					280:287	age-matched controls	268:287	age-matched controls using compositional Magnetic Resonance Imaging (MRI)	268:340	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	1	16	theme	intervertebral	129:142	arg1	discs					144:148	intervertebral discs	129:148	intervertebral discs (IVD)	129:154	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	1	16	theme	intervertebral	129:142	arg1	IVD					151:153	IVD	151:153	IVD	151:153	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	3	17	dep	age	485:487	arg1	23.9 ± 3.3 years					490:505	23.9 ± 3.3 years	490:505	mean age: 23.9 ± 3.3 years	480:505	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	8	18	dep	present	1362:1368	arg1	anymore					1370:1376	anymore	1370:1376	anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362)	1370:1439	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	9	19	theme	higher	1531:1536	arg1	values					1546:1551	significantly higher gagCEST values	1517:1551	significantly higher gagCEST values	1517:1551	CONCLUSIONS Professional elite-level rowing is transiently associated with significantly higher gagCEST values, which indicate increased lumbar IVD-GAG content and strong remodeling effects in response to training.
34400092	5	20	dep	points	808:813	arg1	t0					816:817	t0	816:817	t0: n = 11; t1: n = 11	816:837	Controls (n = 22, mean age: 26.3 ± 1.9 years) were imaged once at corresponding time points (t0: n = 11; t1: n = 11).
34400092	4	21	theme	intensive	627:635	arg1	t0					661:662	t0	661:662	t0	661:662	ERs were imaged twice during the annual training cycle, i.e., at training intensive preseason preparations (t0) and 6 months later during post-competition recovery (t1).
34400092	4	21	theme	intensive	627:635	arg1	preparations					647:658	intensive preseason preparations	627:658	intensive preseason preparations (t0)	627:663	ERs were imaged twice during the annual training cycle, i.e., at training intensive preseason preparations (t0) and 6 months later during post-competition recovery (t1).
34400092	6	22	theme	lumbar	894:899	arg1	IVDs					901:904	lumbar IVDs	894:904	lumbar IVDs (n = 195)	894:914	Segment-wise, the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195) was determined using glycosaminoglycan chemical exchange saturation transfer (gagCEST).
34400092	6	22	theme	lumbar	894:899	arg1	n = 195					907:913	n = 195	907:913	n = 195	907:913	Segment-wise, the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195) was determined using glycosaminoglycan chemical exchange saturation transfer (gagCEST).
34400092	7	23	theme	GAG	1093:1095	arg1	content					1097:1103	GAG content	1093:1103	GAG content	1093:1103	Linear mixed models were set up to assess the influence of cohort and other variables on GAG content.
34400092	8	24	theme	post-competition	1309:1324	arg1	recovery					1326:1333	post-competition recovery	1309:1333	post-competition recovery	1309:1333	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	3	25	dep	METHODS	382:388	arg1	imaged					513:518	imaged	513:518	were imaged on a clinical 3.0 T MRI scanner	508:550	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	1	26	theme	remodeling	115:124	arg1	knowledge					85:93	in-vivo knowledge	77:93	in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD)	77:154	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	7	27	theme	variables	1080:1088	arg1	influence					1050:1058	the influence	1046:1058	the influence of cohort and other variables on GAG content	1046:1103	Linear mixed models were set up to assess the influence of cohort and other variables on GAG content.
34400092	9	28	theme	increased	1569:1577	arg1	content					1594:1600	increased lumbar IVD-GAG content	1569:1600	increased lumbar IVD-GAG content	1569:1600	CONCLUSIONS Professional elite-level rowing is transiently associated with significantly higher gagCEST values, which indicate increased lumbar IVD-GAG content and strong remodeling effects in response to training.
34400092	3	29	theme	rowers	431:436	arg1	spines					412:417	lumbar spines	405:417	lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years)	405:506	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	1	30	theme	in-vivo	77:83	arg1	knowledge					85:93	in-vivo knowledge	77:93	in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD)	77:154	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	6	31	theme	exchange	964:971	arg1	gagCEST					994:1000	gagCEST	994:1000	gagCEST	994:1000	Segment-wise, the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195) was determined using glycosaminoglycan chemical exchange saturation transfer (gagCEST).
34400092	6	31	theme	exchange	964:971	arg1	transfer					984:991	glycosaminoglycan chemical exchange saturation transfer	937:991	glycosaminoglycan chemical exchange saturation transfer (gagCEST)	937:1001	Segment-wise, the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195) was determined using glycosaminoglycan chemical exchange saturation transfer (gagCEST).
34400092	9	32	theme	IVD-GAG	1586:1592	arg1	content					1594:1600	increased lumbar IVD-GAG content	1569:1600	increased lumbar IVD-GAG content	1569:1600	CONCLUSIONS Professional elite-level rowing is transiently associated with significantly higher gagCEST values, which indicate increased lumbar IVD-GAG content and strong remodeling effects in response to training.
34400092	5	33	dep	t0	816:817	arg1	n = 11					832:837	n = 11	832:837	t0: n = 11; t1: n = 11	816:837	Controls (n = 22, mean age: 26.3 ± 1.9 years) were imaged once at corresponding time points (t0: n = 11; t1: n = 11).
34400092	5	33	dep	t0	816:817	arg1	t1					828:829	t1	828:829	t0: n = 11; t1: n = 11	816:837	Controls (n = 22, mean age: 26.3 ± 1.9 years) were imaged once at corresponding time points (t0: n = 11; t1: n = 11).
34400092	5	33	dep	t0	816:817	arg1	n = 11					820:825	n = 11	820:825	n = 11	820:825	Controls (n = 22, mean age: 26.3 ± 1.9 years) were imaged once at corresponding time points (t0: n = 11; t1: n = 11).
34400092	5	34	theme	mean	741:744	arg1	age					746:748	mean age	741:748	mean age: 26.3 ± 1.9 years	741:766	Controls (n = 22, mean age: 26.3 ± 1.9 years) were imaged once at corresponding time points (t0: n = 11; t1: n = 11).
34400092	6	35	theme	glycosaminoglycan	937:953	arg1	gagCEST					994:1000	gagCEST	994:1000	gagCEST	994:1000	Segment-wise, the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195) was determined using glycosaminoglycan chemical exchange saturation transfer (gagCEST).
34400092	6	35	theme	glycosaminoglycan	937:953	arg1	transfer					984:991	glycosaminoglycan chemical exchange saturation transfer	937:991	glycosaminoglycan chemical exchange saturation transfer (gagCEST)	937:1001	Segment-wise, the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195) was determined using glycosaminoglycan chemical exchange saturation transfer (gagCEST).
34400092	4	36	theme	post-competition	691:706	arg1	t1					718:719	t1	718:719	t1	718:719	ERs were imaged twice during the annual training cycle, i.e., at training intensive preseason preparations (t0) and 6 months later during post-competition recovery (t1).
34400092	4	36	theme	post-competition	691:706	arg1	recovery					708:715	post-competition recovery	691:715	post-competition recovery (t1)	691:720	ERs were imaged twice during the annual training cycle, i.e., at training intensive preseason preparations (t0) and 6 months later during post-competition recovery (t1).
34400092	0	37	theme	exercise-induced	11:26	arg1	remodeling					35:44	exercise-induced spinal remodeling	11:44	exercise-induced spinal remodeling	11:44	Imaging of exercise-induced spinal remodeling in elite rowers.
34400092	1	38	theme	age-matched	268:278	arg1	controls					280:287	age-matched controls	268:287	age-matched controls using compositional Magnetic Resonance Imaging (MRI)	268:340	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	8	39	dep	RESULTS	1106:1112	arg1	higher					1173:1178	higher	1173:1178	higher	1173:1178	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	9	40	theme	remodeling	1613:1622	arg1	effects					1624:1630	strong remodeling effects	1606:1630	strong remodeling effects	1606:1630	CONCLUSIONS Professional elite-level rowing is transiently associated with significantly higher gagCEST values, which indicate increased lumbar IVD-GAG content and strong remodeling effects in response to training.
34400092	0	41	theme	remodeling	35:44	arg1	Imaging					0:6	Imaging	0:6	Imaging of exercise-induced spinal remodeling in elite rowers.	0:61	Imaging of exercise-induced spinal remodeling in elite rowers.
34400092	3	42	theme	rowing	467:472	arg1	team					474:477	the German national rowing team	447:477	the German national rowing team (mean age: 23.9 ± 3.3 years)	447:506	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	0	43	theme	elite	49:53	arg1	rowers					55:60	elite rowers	49:60	elite rowers	49:60	Imaging of exercise-induced spinal remodeling in elite rowers.
34400092	1	44	theme	Magnetic	309:316	arg1	MRI					337:339	MRI	337:339	MRI	337:339	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	1	44	theme	Magnetic	309:316	arg1	Imaging					328:334	compositional Magnetic Resonance Imaging	295:334	compositional Magnetic Resonance Imaging (MRI)	295:340	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	3	45	theme	German	451:456	arg1	team					474:477	the German national rowing team	447:477	the German national rowing team (mean age: 23.9 ± 3.3 years)	447:506	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	2	46	theme	case-control	362:373	arg1	study					375:379	Prospective case-control study	350:379	Prospective case-control study	350:379	DESIGN Prospective case-control study.
34400092	7	47	theme	mixed	1011:1015	arg1	models					1017:1022	Linear mixed models	1004:1022	Linear mixed models	1004:1022	Linear mixed models were set up to assess the influence of cohort and other variables on GAG content.
34400092	1	48	theme	long-term	227:235	arg1	training					237:244	long-term training	227:244	long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI)	227:340	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	10	49	theme	full-body	1704:1712	arg1	exercise					1714:1721	core-strengthening full-body exercise	1685:1721	core-strengthening full-body exercise	1685:1721	Beyond professional rowing, core-strengthening full-body exercise may help to enhance the resilience of the lumbar spine as a potential therapeutic target in treating back pain.
34400092	5	50	dep	n = 22	733:738	arg1	age					746:748	mean age	741:748	mean age: 26.3 ± 1.9 years	741:766	Controls (n = 22, mean age: 26.3 ± 1.9 years) were imaged once at corresponding time points (t0: n = 11; t1: n = 11).
34400092	1	51	from	athletes	255:262	arg1	function					215:222	a function	213:222	a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI)	213:340	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	3	52	theme	clinical	525:532	arg1	scanner					544:550	a clinical 3.0 T MRI scanner	523:550	a clinical 3.0 T MRI scanner	523:550	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	5	53	theme	corresponding	789:801	arg1	points					808:813	corresponding time points	789:813	corresponding time points (t0: n = 11; t1: n = 11)	789:838	Controls (n = 22, mean age: 26.3 ± 1.9 years) were imaged once at corresponding time points (t0: n = 11; t1: n = 11).
34400092	5	54	dep	Controls	723:730	arg1	n = 22					733:738	n = 22	733:738	n = 22	733:738	Controls (n = 22, mean age: 26.3 ± 1.9 years) were imaged once at corresponding time points (t0: n = 11; t1: n = 11).
34400092	10	55	theme	lumbar	1765:1770	arg1	spine					1772:1776	the lumbar spine	1761:1776	the lumbar spine	1761:1776	Beyond professional rowing, core-strengthening full-body exercise may help to enhance the resilience of the lumbar spine as a potential therapeutic target in treating back pain.
34400092	8	56	theme	IVD	1132:1134	arg1	values					1140:1145	IVD GAG values	1132:1145	IVD GAG values of ERs	1132:1152	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	9	57	theme	CONCLUSIONS	1442:1452	arg1	Professional					1454:1465	CONCLUSIONS Professional	1442:1465	CONCLUSIONS Professional elite-level rowing	1442:1484	CONCLUSIONS Professional elite-level rowing is transiently associated with significantly higher gagCEST values, which indicate increased lumbar IVD-GAG content and strong remodeling effects in response to training.
34400092	8	58	dep	ERs	1204:1206	arg1	deviations					1243:1252	mean ± standard deviations	1227:1252	mean ± standard deviations	1227:1252	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	8	58	dep	ERs	1204:1206	arg1	%					1281:1281	1.43 ± 0.36%	1270:1281	ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001	1204:1292	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	8	58	dep	ERs	1204:1206	arg1	%					1224:1224	2.58 ± 0.27%	1213:1224	ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001	1204:1292	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	8	58	dep	ERs	1204:1206	arg1	controls					1256:1263	controls	1256:1263	ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001	1204:1292	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	8	58	dep	ERs	1204:1206	arg1	t0					1265:1266	t0	1265:1266	t0	1265:1266	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	8	58	dep	ERs	1204:1206	arg1	p ≤ 0.001					1284:1292	p ≤ 0.001	1284:1292	p ≤ 0.001	1284:1292	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	4	59	theme	training	593:600	arg1	cycle					602:606	the annual training cycle	582:606	the annual training cycle	582:606	ERs were imaged twice during the annual training cycle, i.e., at training intensive preseason preparations (t0) and 6 months later during post-competition recovery (t1).
34400092	10	60	theme	potential	1783:1791	arg1	target					1805:1810	a potential therapeutic target	1781:1810	a potential therapeutic target in treating back pain	1781:1832	Beyond professional rowing, core-strengthening full-body exercise may help to enhance the resilience of the lumbar spine as a potential therapeutic target in treating back pain.
34400092	10	60	theme	potential	1783:1791	arg1	resilience					1747:1756	the resilience	1743:1756	the resilience of the lumbar spine	1743:1776	Beyond professional rowing, core-strengthening full-body exercise may help to enhance the resilience of the lumbar spine as a potential therapeutic target in treating back pain.
34400092	1	61	from	function	215:222	arg1	athletes					255:262	elite athletes	249:262	elite athletes	249:262	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	1	61	from	function	215:222	arg1	controls					280:287	age-matched controls	268:287	age-matched controls using compositional Magnetic Resonance Imaging (MRI)	268:340	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	8	62	dep	ERs	1379:1381	arg1	%					1427:1427	1.89 ± 0.24%	1416:1427	ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362	1379:1438	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	8	62	dep	ERs	1379:1381	arg1	%					1399:1399	2.11 ± 0.18%	1388:1399	ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362	1379:1438	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	8	62	dep	ERs	1379:1381	arg1	t1					1411:1412	t1	1411:1412	t1	1411:1412	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	8	62	dep	ERs	1379:1381	arg1	controls					1402:1409	controls	1402:1409	ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362	1379:1438	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	8	62	dep	ERs	1379:1381	arg1	p = 0.362					1430:1438	p = 0.362	1430:1438	p = 0.362	1430:1438	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	3	63	theme	MRI	540:542	arg1	scanner					544:550	a clinical 3.0 T MRI scanner	523:550	a clinical 3.0 T MRI scanner	523:550	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	0	64	from	Imaging	0:6	arg1	rowers					55:60	elite rowers	49:60	elite rowers	49:60	Imaging of exercise-induced spinal remodeling in elite rowers.
34400092	8	65	theme	ERs	1150:1152	arg1	values					1140:1145	IVD GAG values	1132:1145	IVD GAG values of ERs	1132:1152	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	8	66	dep	anymore	1370:1376	arg1	t1					1383:1384	t1	1383:1384	t1	1383:1384	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	8	66	dep	anymore	1370:1376	arg1	ERs					1379:1381	ERs	1379:1381	ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362	1379:1438	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	1	67	theme	discs	144:148	arg1	remodeling					115:124	training-induced remodeling	98:124	training-induced remodeling of intervertebral discs (IVD)	98:154	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	8	68	theme	GAG	1136:1138	arg1	values					1140:1145	IVD GAG values	1132:1145	IVD GAG values of ERs	1132:1152	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	6	69	theme	IVDs	901:904	arg1	content					883:889	the glycosaminoglycan (GAG) content	855:889	the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195)	855:914	Segment-wise, the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195) was determined using glycosaminoglycan chemical exchange saturation transfer (gagCEST).
34400092	9	70	theme	gagCEST	1538:1544	arg1	values					1546:1551	significantly higher gagCEST values	1517:1551	significantly higher gagCEST values	1517:1551	CONCLUSIONS Professional elite-level rowing is transiently associated with significantly higher gagCEST values, which indicate increased lumbar IVD-GAG content and strong remodeling effects in response to training.
34400092	4	71	theme	preseason	637:645	arg1	t0					661:662	t0	661:662	t0	661:662	ERs were imaged twice during the annual training cycle, i.e., at training intensive preseason preparations (t0) and 6 months later during post-competition recovery (t1).
34400092	4	71	theme	preseason	637:645	arg1	preparations					647:658	intensive preseason preparations	627:658	intensive preseason preparations (t0)	627:663	ERs were imaged twice during the annual training cycle, i.e., at training intensive preseason preparations (t0) and 6 months later during post-competition recovery (t1).
34400092	7	72	theme	other	1074:1078	arg1	variables					1080:1088	other variables	1074:1088	other variables	1074:1088	Linear mixed models were set up to assess the influence of cohort and other variables on GAG content.
34400092	8	73	theme	such	1336:1339	arg1	differences					1341:1351	such differences	1336:1351	such differences	1336:1351	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	7	74	theme	cohort	1063:1068	arg1	influence					1050:1058	the influence	1046:1058	the influence of cohort and other variables on GAG content	1046:1103	Linear mixed models were set up to assess the influence of cohort and other variables on GAG content.
34400092	6	75	theme	saturation	973:982	arg1	gagCEST					994:1000	gagCEST	994:1000	gagCEST	994:1000	Segment-wise, the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195) was determined using glycosaminoglycan chemical exchange saturation transfer (gagCEST).
34400092	6	75	theme	saturation	973:982	arg1	transfer					984:991	glycosaminoglycan chemical exchange saturation transfer	937:991	glycosaminoglycan chemical exchange saturation transfer (gagCEST)	937:1001	Segment-wise, the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195) was determined using glycosaminoglycan chemical exchange saturation transfer (gagCEST).
34400092	9	76	theme	lumbar	1579:1584	arg1	content					1594:1600	increased lumbar IVD-GAG content	1569:1600	increased lumbar IVD-GAG content	1569:1600	CONCLUSIONS Professional elite-level rowing is transiently associated with significantly higher gagCEST values, which indicate increased lumbar IVD-GAG content and strong remodeling effects in response to training.
34400092	7	77	from	influence	1050:1058	arg1	content					1097:1103	GAG content	1093:1103	GAG content	1093:1103	Linear mixed models were set up to assess the influence of cohort and other variables on GAG content.
34400092	10	78	dep	potential	1783:1791	arg1	therapeutic					1793:1803	therapeutic	1793:1803	therapeutic	1793:1803	Beyond professional rowing, core-strengthening full-body exercise may help to enhance the resilience of the lumbar spine as a potential therapeutic target in treating back pain.
34400092	6	79	theme	chemical	955:962	arg1	gagCEST					994:1000	gagCEST	994:1000	gagCEST	994:1000	Segment-wise, the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195) was determined using glycosaminoglycan chemical exchange saturation transfer (gagCEST).
34400092	6	79	theme	chemical	955:962	arg1	transfer					984:991	glycosaminoglycan chemical exchange saturation transfer	937:991	glycosaminoglycan chemical exchange saturation transfer (gagCEST)	937:1001	Segment-wise, the glycosaminoglycan (GAG) content of lumbar IVDs (n = 195) was determined using glycosaminoglycan chemical exchange saturation transfer (gagCEST).
34400092	1	80	dep	scarce	159:164	arg1	assessed					178:185	assessed	178:185	assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI)	178:340	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	3	81	theme	elite	425:429	arg1	rowers					431:436	17 elite rowers	422:436	17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years)	422:506	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	3	81	theme	elite	425:429	arg1	ERs					439:441	ERs	439:441	ERs	439:441	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	0	82	theme	spinal	28:33	arg1	remodeling					35:44	exercise-induced spinal remodeling	11:44	exercise-induced spinal remodeling	11:44	Imaging of exercise-induced spinal remodeling in elite rowers.
34400092	1	83	theme	training-induced	98:113	arg1	remodeling					115:124	training-induced remodeling	98:124	training-induced remodeling of intervertebral discs (IVD)	98:154	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	9	84	theme	strong	1606:1611	arg1	effects					1624:1630	strong remodeling effects	1606:1630	strong remodeling effects	1606:1630	CONCLUSIONS Professional elite-level rowing is transiently associated with significantly higher gagCEST values, which indicate increased lumbar IVD-GAG content and strong remodeling effects in response to training.
34400092	8	85	dep	controls	1194:1201	arg1	t0					1208:1209	t0	1208:1209	t0	1208:1209	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	8	85	dep	controls	1194:1201	arg1	ERs					1204:1206	ERs	1204:1206	ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001	1204:1292	RESULTS During preseason, IVD GAG values of ERs were significantly higher than those of controls (ERs(t0): 2.58 ± 0.27% (mean ± standard deviations); controls(t0): 1.43 ± 0.36%; p ≤ 0.001), while during post-competition recovery, such differences were not present anymore (ERs(t1): 2.11 ± 0.18%; controls(t1): 1.89 ± 0.24%; p = 0.362).
34400092	1	86	theme	compositional	295:307	arg1	MRI					337:339	MRI	337:339	MRI	337:339	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	1	86	theme	compositional	295:307	arg1	Imaging					328:334	compositional Magnetic Resonance Imaging	295:334	compositional Magnetic Resonance Imaging (MRI)	295:340	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	3	87	theme	lumbar	405:410	arg1	spines					412:417	lumbar spines	405:417	lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years)	405:506	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	10	88	theme	core-strengthening	1685:1702	arg1	exercise					1714:1721	core-strengthening full-body exercise	1685:1721	core-strengthening full-body exercise	1685:1721	Beyond professional rowing, core-strengthening full-body exercise may help to enhance the resilience of the lumbar spine as a potential therapeutic target in treating back pain.
34400092	3	89	theme	team	474:477	arg1	rowers					431:436	17 elite rowers	422:436	17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years)	422:506	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	3	89	theme	team	474:477	arg1	ERs					439:441	ERs	439:441	ERs	439:441	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	1	90	theme	Resonance	318:326	arg1	MRI					337:339	MRI	337:339	MRI	337:339	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	1	90	theme	Resonance	318:326	arg1	Imaging					328:334	compositional Magnetic Resonance Imaging	295:334	compositional Magnetic Resonance Imaging (MRI)	295:340	OBJECTIVES As in-vivo knowledge of training-induced remodeling of intervertebral discs (IVD) is scarce, this study assessed how lumbar IVDs change as a function of long-term training in elite athletes and age-matched controls using compositional Magnetic Resonance Imaging (MRI).
34400092	3	91	dep	team	474:477	arg1	age					485:487	mean age	480:487	mean age: 23.9 ± 3.3 years	480:505	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	2	92	dep	study	375:379	arg1	DESIGN					343:348	DESIGN	343:348	DESIGN	343:348	DESIGN Prospective case-control study.
34400092	3	93	theme	national	458:465	arg1	team					474:477	the German national rowing team	447:477	the German national rowing team (mean age: 23.9 ± 3.3 years)	447:506	METHODS Prospectively, lumbar spines of 17 elite rowers (ERs) of the German national rowing team (mean age: 23.9 ± 3.3 years) were imaged on a clinical 3.0 T MRI scanner.
34400092	2	94	theme	Prospective	350:360	arg1	study					375:379	Prospective case-control study	350:379	Prospective case-control study	350:379	DESIGN Prospective case-control study.
32750484	0	0	theme	walnut	86:91	arg1	shell					93:97	the walnut shell	82:97	the walnut shell	82:97	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	8	1	theme	NCCF	1125:1128	arg1	's					1129:1130	converted agro-based NCCF's	1104:1130	converted agro-based NCCF's	1104:1130	Functional group compositions of cellulose were observed to be intact for converted agro-based NCCF's.
32750484	6	2	theme	sugarcane	846:854	arg1	fiber					825:829	Nanocrystalline cellulose fiber	799:829	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse	799:862	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse was estimated to have a low thermal degradation temperature.
32750484	4	3	theme	bagasse	666:672	arg1	cellulose					674:682	sugarcane bagasse cellulose	656:682	sugarcane bagasse cellulose	656:682	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose were higher than corncob cellulose.
32750484	7	4	theme	type	1012:1015	arg1	cellulose					1019:1027	type I cellulose	1012:1027	type I cellulose	1012:1027	All the MCCs and NCCFs produced from investigated cellulose sources were found to have type I cellulose.
32750484	1	5	theme	agro-industrial	240:254	arg1	wastes					256:261	different agro-industrial wastes	230:261	different agro-industrial wastes such as walnut shells	230:283	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	1	5	theme	agro-industrial	240:254	arg1	shells					278:283	walnut shells	271:283	walnut shells	271:283	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	2	6	theme	chemical	493:500	arg1	natures					502:508	morphological, structural, thermal, and chemical natures	453:508	morphological, structural, thermal, and chemical natures	453:508	Moreover, it is also the aim of this study to convert MCCs to nanocrystalline cellulose fiber (NCCF), to demonstrate the difference in morphological, structural, thermal, and chemical natures.
32750484	4	7	theme	sugarcane	656:664	arg1	cellulose					674:682	sugarcane bagasse cellulose	656:682	sugarcane bagasse cellulose	656:682	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose were higher than corncob cellulose.
32750484	6	8	contain	have	881:884	arg1	fiber					825:829	Nanocrystalline cellulose fiber	799:829	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse	799:862	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse was estimated to have a low thermal degradation temperature.
32750484	6	8	contain	have	881:884	arg2	temperature					912:922	a low thermal degradation temperature	886:922	a low thermal degradation temperature	886:922	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse was estimated to have a low thermal degradation temperature.
32750484	2	9	theme	thermal	480:486	arg1	natures					502:508	morphological, structural, thermal, and chemical natures	453:508	morphological, structural, thermal, and chemical natures	453:508	Moreover, it is also the aim of this study to convert MCCs to nanocrystalline cellulose fiber (NCCF), to demonstrate the difference in morphological, structural, thermal, and chemical natures.
32750484	4	10	from	shell	646:650	arg1	yield					628:632	Nanocrystalline cellulose fiber yield	596:632	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose	596:682	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose were higher than corncob cellulose.
32750484	6	11	dep	corncob	834:840	arg1	bagasse					856:862	bagasse	856:862	bagasse	856:862	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse was estimated to have a low thermal degradation temperature.
32750484	6	12	theme	degradation	900:910	arg1	temperature					912:922	a low thermal degradation temperature	886:922	a low thermal degradation temperature	886:922	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse was estimated to have a low thermal degradation temperature.
32750484	7	13	contain	have	1007:1010	arg1	NCCFs					942:946	NCCFs	942:946	NCCFs	942:946	All the MCCs and NCCFs produced from investigated cellulose sources were found to have type I cellulose.
32750484	7	13	contain	have	1007:1010	arg1	MCCs					933:936	MCCs	933:936	MCCs	933:936	All the MCCs and NCCFs produced from investigated cellulose sources were found to have type I cellulose.
32750484	7	13	contain	have	1007:1010	arg2	cellulose					1019:1027	type I cellulose	1012:1027	type I cellulose	1012:1027	All the MCCs and NCCFs produced from investigated cellulose sources were found to have type I cellulose.
32750484	3	14	contain	possess	545:551	arg2	structure					585:593	a loosely bounded linear bundle structure	553:593	a loosely bounded linear bundle structure	553:593	Corncob cellulose was observed to possess a loosely bounded linear bundle structure.
32750484	3	14	contain	possess	545:551	arg1	cellulose					519:527	Corncob cellulose	511:527	Corncob cellulose	511:527	Corncob cellulose was observed to possess a loosely bounded linear bundle structure.
32750484	2	15	theme	structural	468:477	arg1	natures					502:508	morphological, structural, thermal, and chemical natures	453:508	morphological, structural, thermal, and chemical natures	453:508	Moreover, it is also the aim of this study to convert MCCs to nanocrystalline cellulose fiber (NCCF), to demonstrate the difference in morphological, structural, thermal, and chemical natures.
32750484	8	16	theme	converted	1104:1112	arg1	's					1129:1130	converted agro-based NCCF's	1104:1130	converted agro-based NCCF's	1104:1130	Functional group compositions of cellulose were observed to be intact for converted agro-based NCCF's.
32750484	7	17	theme	investigated	962:973	arg1	sources					985:991	investigated cellulose sources	962:991	investigated cellulose sources	962:991	All the MCCs and NCCFs produced from investigated cellulose sources were found to have type I cellulose.
32750484	2	18	theme	study	355:359	arg1	it					328:329	it	328:329	it	328:329	Moreover, it is also the aim of this study to convert MCCs to nanocrystalline cellulose fiber (NCCF), to demonstrate the difference in morphological, structural, thermal, and chemical natures.
32750484	2	18	theme	study	355:359	arg1	aim					343:345	the aim	339:345	the aim of this study to convert MCCs to nanocrystalline cellulose fiber (NCCF), to demonstrate the difference in morphological, structural, thermal, and chemical natures	339:508	Moreover, it is also the aim of this study to convert MCCs to nanocrystalline cellulose fiber (NCCF), to demonstrate the difference in morphological, structural, thermal, and chemical natures.
32750484	5	19	theme	cellulose	745:753	arg1	stability					732:740	The thermal stability	720:740	The thermal stability of cellulose	720:753	The thermal stability of cellulose was noted to be high for walnut shell NCCF.
32750484	5	19	theme	cellulose	745:753	arg1	high					771:774	high	771:774	high	771:774	The thermal stability of cellulose was noted to be high for walnut shell NCCF.
32750484	8	20	theme	group	1041:1045	arg1	compositions					1047:1058	Functional group compositions	1030:1058	Functional group compositions of cellulose	1030:1071	Functional group compositions of cellulose were observed to be intact for converted agro-based NCCF's.
32750484	5	21	theme	thermal	724:730	arg1	stability					732:740	The thermal stability	720:740	The thermal stability of cellulose	720:753	The thermal stability of cellulose was noted to be high for walnut shell NCCF.
32750484	5	21	theme	thermal	724:730	arg1	high					771:774	high	771:774	high	771:774	The thermal stability of cellulose was noted to be high for walnut shell NCCF.
32750484	4	22	theme	walnut	639:644	arg1	shell					646:650	walnut shell	639:650	walnut shell	639:650	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose were higher than corncob cellulose.
32750484	1	23	theme	walnut	271:276	arg1	shells					278:283	walnut shells	271:283	walnut shells	271:283	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	8	24	theme	Functional	1030:1039	arg1	compositions					1047:1058	Functional group compositions	1030:1058	Functional group compositions of cellulose	1030:1071	Functional group compositions of cellulose were observed to be intact for converted agro-based NCCF's.
32750484	4	25	theme	corncob	701:707	arg1	cellulose					709:717	corncob cellulose	701:717	corncob cellulose	701:717	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose were higher than corncob cellulose.
32750484	2	26	theme	fiber	406:410	arg1	NCCF					413:416	nanocrystalline cellulose fiber (NCCF)	380:417	nanocrystalline cellulose fiber (NCCF)	380:417	Moreover, it is also the aim of this study to convert MCCs to nanocrystalline cellulose fiber (NCCF), to demonstrate the difference in morphological, structural, thermal, and chemical natures.
32750484	2	27	theme	nanocrystalline	380:394	arg1	NCCF					413:416	nanocrystalline cellulose fiber (NCCF)	380:417	nanocrystalline cellulose fiber (NCCF)	380:417	Moreover, it is also the aim of this study to convert MCCs to nanocrystalline cellulose fiber (NCCF), to demonstrate the difference in morphological, structural, thermal, and chemical natures.
32750484	2	28	theme	cellulose	396:404	arg1	NCCF					413:416	nanocrystalline cellulose fiber (NCCF)	380:417	nanocrystalline cellulose fiber (NCCF)	380:417	Moreover, it is also the aim of this study to convert MCCs to nanocrystalline cellulose fiber (NCCF), to demonstrate the difference in morphological, structural, thermal, and chemical natures.
32750484	0	29	theme	sugarcane	112:120	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	0	29	theme	sugarcane	112:120	arg1	bagasse					122:128	sugarcane bagasse	112:128	sugarcane bagasse	112:128	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	2	30	from	difference	439:448	arg1	natures					502:508	morphological, structural, thermal, and chemical natures	453:508	morphological, structural, thermal, and chemical natures	453:508	Moreover, it is also the aim of this study to convert MCCs to nanocrystalline cellulose fiber (NCCF), to demonstrate the difference in morphological, structural, thermal, and chemical natures.
32750484	3	31	theme	Corncob	511:517	arg1	cellulose					519:527	Corncob cellulose	511:527	Corncob cellulose	511:527	Corncob cellulose was observed to possess a loosely bounded linear bundle structure.
32750484	6	32	theme	corncob	834:840	arg1	fiber					825:829	Nanocrystalline cellulose fiber	799:829	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse	799:862	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse was estimated to have a low thermal degradation temperature.
32750484	1	33	attach	present	219:225	arg2	MCC					214:216	MCC	214:216	MCC	214:216	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	1	33	attach	present	219:225	arg1	wastes					256:261	different agro-industrial wastes	230:261	different agro-industrial wastes such as walnut shells	230:283	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	1	33	attach	present	219:225	arg2	cellulose					203:211	the microcrystalline cellulose	182:211	the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells	182:283	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	1	33	attach	present	219:225	arg1	shells					278:283	walnut shells	271:283	walnut shells	271:283	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	4	34	from	cellulose	674:682	arg1	yield					628:632	Nanocrystalline cellulose fiber yield	596:632	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose	596:682	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose were higher than corncob cellulose.
32750484	4	35	theme	cellulose	612:620	arg1	yield					628:632	Nanocrystalline cellulose fiber yield	596:632	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose	596:682	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose were higher than corncob cellulose.
32750484	0	36	theme	micro	34:38	arg1	characterization					14:29	characterization	14:29	characterization	14:29	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	0	36	theme	micro	34:38	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	0	36	theme	micro	34:38	arg1	corncob					100:106	corncob	100:106	corncob	100:106	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	0	36	theme	micro	34:38	arg1	bagasse					122:128	sugarcane bagasse	112:128	sugarcane bagasse	112:128	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	1	37	from	wastes	256:261	arg1	present					219:225	present	219:225	present	219:225	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	8	38	theme	agro-based	1114:1123	arg1	's					1129:1130	converted agro-based NCCF's	1104:1130	converted agro-based NCCF's	1104:1130	Functional group compositions of cellulose were observed to be intact for converted agro-based NCCF's.
32750484	5	39	theme	walnut	780:785	arg1	NCCF					793:796	walnut shell NCCF	780:796	walnut shell NCCF	780:796	The thermal stability of cellulose was noted to be high for walnut shell NCCF.
32750484	4	40	theme	Nanocrystalline	596:610	arg1	yield					628:632	Nanocrystalline cellulose fiber yield	596:632	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose	596:682	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose were higher than corncob cellulose.
32750484	0	41	theme	cellulose	60:68	arg1	fibers					70:75	nanocrystalline cellulose fibers	44:75	nanocrystalline cellulose fibers	44:75	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	5	42	theme	shell	787:791	arg1	NCCF					793:796	walnut shell NCCF	780:796	walnut shell NCCF	780:796	The thermal stability of cellulose was noted to be high for walnut shell NCCF.
32750484	0	43	theme	nanocrystalline	44:58	arg1	fibers					70:75	nanocrystalline cellulose fibers	44:75	nanocrystalline cellulose fibers	44:75	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	1	44	theme	sugarcane	299:307	arg1	bagasse					309:315	sugarcane bagasse	299:315	sugarcane bagasse	299:315	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	7	45	theme	I	1017:1017	arg1	cellulose					1019:1027	type I cellulose	1012:1027	type I cellulose	1012:1027	All the MCCs and NCCFs produced from investigated cellulose sources were found to have type I cellulose.
32750484	6	46	theme	cellulose	815:823	arg1	fiber					825:829	Nanocrystalline cellulose fiber	799:829	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse	799:862	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse was estimated to have a low thermal degradation temperature.
32750484	7	47	theme	cellulose	975:983	arg1	sources					985:991	investigated cellulose sources	962:991	investigated cellulose sources	962:991	All the MCCs and NCCFs produced from investigated cellulose sources were found to have type I cellulose.
32750484	6	48	theme	thermal	892:898	arg1	temperature					912:922	a low thermal degradation temperature	886:922	a low thermal degradation temperature	886:922	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse was estimated to have a low thermal degradation temperature.
32750484	6	49	theme	Nanocrystalline	799:813	arg1	fiber					825:829	Nanocrystalline cellulose fiber	799:829	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse	799:862	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse was estimated to have a low thermal degradation temperature.
32750484	3	50	theme	linear	571:576	arg1	structure					585:593	a loosely bounded linear bundle structure	553:593	a loosely bounded linear bundle structure	553:593	Corncob cellulose was observed to possess a loosely bounded linear bundle structure.
32750484	1	51	from	present	219:225	arg1	wastes					256:261	different agro-industrial wastes	230:261	different agro-industrial wastes such as walnut shells	230:283	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	1	51	from	present	219:225	arg1	shells					278:283	walnut shells	271:283	walnut shells	271:283	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	3	52	theme	bundle	578:583	arg1	structure					585:593	a loosely bounded linear bundle structure	553:593	a loosely bounded linear bundle structure	553:593	Corncob cellulose was observed to possess a loosely bounded linear bundle structure.
32750484	7	53	dep	MCCs	933:936	arg1	the					929:931	the	929:931	the	929:931	All the MCCs and NCCFs produced from investigated cellulose sources were found to have type I cellulose.
32750484	7	53	dep	MCCs	933:936	arg1	All					925:927	All	925:927	All	925:927	All the MCCs and NCCFs produced from investigated cellulose sources were found to have type I cellulose.
32750484	1	54	theme	present	219:225	arg1	cellulose					203:211	the microcrystalline cellulose	182:211	the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells	182:283	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	1	54	theme	present	219:225	arg1	MCC					214:216	MCC	214:216	MCC	214:216	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	2	55	theme	morphological	453:465	arg1	natures					502:508	morphological, structural, thermal, and chemical natures	453:508	morphological, structural, thermal, and chemical natures	453:508	Moreover, it is also the aim of this study to convert MCCs to nanocrystalline cellulose fiber (NCCF), to demonstrate the difference in morphological, structural, thermal, and chemical natures.
32750484	0	56	from	shell	93:97	arg1	characterization					14:29	characterization	14:29	characterization	14:29	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	0	56	from	shell	93:97	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	0	56	from	shell	93:97	arg1	corncob					100:106	corncob	100:106	corncob	100:106	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	0	56	from	shell	93:97	arg1	bagasse					122:128	sugarcane bagasse	112:128	sugarcane bagasse	112:128	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	1	57	theme	microcrystalline	186:201	arg1	cellulose					203:211	the microcrystalline cellulose	182:211	the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells	182:283	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	1	57	theme	microcrystalline	186:201	arg1	MCC					214:216	MCC	214:216	MCC	214:216	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	1	58	theme	present	135:141	arg1	study					143:147	The present study	131:147	The present study	131:147	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	4	59	theme	fiber	622:626	arg1	yield					628:632	Nanocrystalline cellulose fiber yield	596:632	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose	596:682	Nanocrystalline cellulose fiber yield from walnut shell and sugarcane bagasse cellulose were higher than corncob cellulose.
32750484	0	60	theme	fibers	70:75	arg1	characterization					14:29	characterization	14:29	characterization	14:29	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	0	60	theme	fibers	70:75	arg1	Isolation					0:8	Isolation	0:8	Isolation	0:8	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	0	60	theme	fibers	70:75	arg1	corncob					100:106	corncob	100:106	corncob	100:106	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	0	60	theme	fibers	70:75	arg1	bagasse					122:128	sugarcane bagasse	112:128	sugarcane bagasse	112:128	Isolation and characterization of micro and nanocrystalline cellulose fibers from the walnut shell, corncob and sugarcane bagasse.
32750484	6	61	theme	low	888:890	arg1	temperature					912:922	a low thermal degradation temperature	886:922	a low thermal degradation temperature	886:922	Nanocrystalline cellulose fiber of corncob and sugarcane bagasse was estimated to have a low thermal degradation temperature.
32750484	3	62	theme	bounded	563:569	arg1	structure					585:593	a loosely bounded linear bundle structure	553:593	a loosely bounded linear bundle structure	553:593	Corncob cellulose was observed to possess a loosely bounded linear bundle structure.
32750484	8	63	theme	cellulose	1063:1071	arg1	compositions					1047:1058	Functional group compositions	1030:1058	Functional group compositions of cellulose	1030:1071	Functional group compositions of cellulose were observed to be intact for converted agro-based NCCF's.
32750484	1	64	theme	different	230:238	arg1	wastes					256:261	different agro-industrial wastes	230:261	different agro-industrial wastes such as walnut shells	230:283	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
32750484	1	64	theme	different	230:238	arg1	shells					278:283	walnut shells	271:283	walnut shells	271:283	The present study aims to extract and characterize the microcrystalline cellulose (MCC) present in different agro-industrial wastes such as walnut shells, corncob, and sugarcane bagasse.
34480908	7	0	theme	exfoliation	1205:1215	arg1	approach					1217:1224	liquid exfoliation approach	1198:1224	liquid exfoliation approach	1198:1224	Herein, we synthesized biologically active CS/WS2/Ru composite by liquid exfoliation approach.
34480908	4	1	theme	new	607:609	arg1	nanomaterials					614:626	numerous new 2D nanomaterials	598:626	numerous new 2D nanomaterials other than graphene	598:646	In recent years numerous new 2D nanomaterials other than graphene have been reported.
34480908	0	2	theme	pharmaceutical	206:219	arg1	applications					221:232	pharmaceutical applications	206:232	pharmaceutical applications	206:232	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	2	3	theme	2D	386:387	arg1	nanomaterials					389:401	2D nanomaterials	386:401	2D nanomaterials	386:401	So, 2D nanomaterials are unique because of their physicochemical properties.
34480908	0	4	theme	ruthenium	97:105	arg1	nanoparticles					107:119	ruthenium nanoparticles	97:119	ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications	97:232	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	0	4	theme	ruthenium	97:105	arg1	characterization					184:199	characterization	184:199	characterization	184:199	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	0	4	theme	ruthenium	97:105	arg1	Synthesis					173:181	Synthesis	173:181	Synthesis	173:181	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	5	5	theme	nanomaterials	684:696	arg1	study					672:676	The study	668:676	The study of 2D nanomaterials	668:696	The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials.
34480908	10	6	theme	outcomes	1497:1504	arg1	aspects					1475:1481	the innovative aspects	1460:1481	the innovative aspects of biological outcomes in carcinological applications	1460:1535	These reports are possible to explore the innovative aspects of biological outcomes in carcinological applications.
34480908	4	7	theme	2D	611:612	arg1	nanomaterials					614:626	numerous new 2D nanomaterials	598:626	numerous new 2D nanomaterials other than graphene	598:646	In recent years numerous new 2D nanomaterials other than graphene have been reported.
34480908	0	8	theme	in	125:126	arg1	activity					163:170	in vitro antibacterial and anticancer activity	125:170	in vitro antibacterial and anticancer activity	125:170	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	5	9	theme	research	749:756	arg1	majority					737:744	the majority	733:744	the majority of research focusing on the explanation of special material properties	733:815	The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials.
34480908	3	10	theme	significant	531:541	arg1	attention					543:551	significant attention	531:551	significant attention	531:551	Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community.
34480908	4	11	theme	other	628:632	arg1	nanomaterials					614:626	numerous new 2D nanomaterials	598:626	numerous new 2D nanomaterials other than graphene	598:646	In recent years numerous new 2D nanomaterials other than graphene have been reported.
34480908	0	12	theme	antibacterial	134:146	arg1	activity					163:170	in vitro antibacterial and anticancer activity	125:170	in vitro antibacterial and anticancer activity	125:170	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	8	13	theme	antibacterial	1272:1284	arg1	action					1286:1291	significant antibacterial action	1260:1291	significant antibacterial action towards (S. aureus, and E. coli) bacteria	1260:1333	The CS/WS2/Ru composites exhibit significant antibacterial action towards (S. aureus, and E. coli) bacteria.
34480908	0	14	dep	in	125:126	arg1	vitro					128:132	vitro	128:132	vitro	128:132	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	5	15	theme	2D	887:888	arg1	nanomaterials					890:902	2D nanomaterials	887:902	2D nanomaterials	887:902	The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials.
34480908	6	16	theme	great	1064:1068	arg1	opportunities					1070:1082	great opportunities	1064:1082	great opportunities in several fields, such as cancer nanomedicine	1064:1129	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	3	17	contain	has	527:529	arg2	attention					543:551	significant attention	531:551	significant attention	531:551	Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community.
34480908	3	17	contain	has	527:529	arg1	graphene					476:483	graphene	476:483	graphene	476:483	Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community.
34480908	3	17	contain	has	527:529	arg1	element					514:520	a conventional 2D layered element	488:520	a conventional 2D layered element that has significant attention in the scientific community	488:579	Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community.
34480908	5	18	theme	material	797:804	arg1	properties					806:815	special material properties	789:815	special material properties	789:815	The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials.
34480908	10	19	theme	biological	1486:1495	arg1	outcomes					1497:1504	biological outcomes	1486:1504	biological outcomes	1486:1504	These reports are possible to explore the innovative aspects of biological outcomes in carcinological applications.
34480908	7	20	theme	active	1168:1173	arg1	composite					1185:1193	biologically active CS/WS2/Ru composite	1155:1193	biologically active CS/WS2/Ru composite	1155:1193	Herein, we synthesized biologically active CS/WS2/Ru composite by liquid exfoliation approach.
34480908	5	21	with	stages	720:725	arg1	majority					737:744	the majority	733:744	the majority of research focusing on the explanation of special material properties	733:815	The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials.
34480908	5	22	theme	2D	681:682	arg1	nanomaterials					684:696	2D nanomaterials	681:696	2D nanomaterials	681:696	The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials.
34480908	5	23	theme	special	789:795	arg1	properties					806:815	special material properties	789:815	special material properties	789:815	The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials.
34480908	10	24	theme	innovative	1464:1473	arg1	aspects					1475:1481	the innovative aspects	1460:1481	the innovative aspects of biological outcomes in carcinological applications	1460:1535	These reports are possible to explore the innovative aspects of biological outcomes in carcinological applications.
34480908	0	25	dep	nanoparticles	107:119	arg1	applications					221:232	pharmaceutical applications	206:232	pharmaceutical applications	206:232	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	0	25	dep	nanoparticles	107:119	arg1	nanoparticles					107:119	ruthenium nanoparticles	97:119	ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications	97:232	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	0	25	dep	nanoparticles	107:119	arg1	characterization					184:199	characterization	184:199	characterization	184:199	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	0	25	dep	nanoparticles	107:119	arg1	Synthesis					173:181	Synthesis	173:181	Synthesis	173:181	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	3	26	theme	many	464:467	arg1	years					469:473	many years	464:473	many years	464:473	Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community.
34480908	5	27	theme	few	827:829	arg1	articles					831:838	very few articles	822:838	very few articles	822:838	The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials.
34480908	6	28	dep	elements	1042:1049	arg1	display					1056:1062	display	1056:1062	display great opportunities in several fields, such as cancer nanomedicine	1056:1129	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	5	29	theme	nanomaterials	890:902	arg1	applications					871:882	the biological applications	856:882	the biological applications of 2D nanomaterials	856:902	The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials.
34480908	0	30	theme	chitosan	28:35	arg1	WS2					64:66	eco-friendly chitosan functionalized few-layered WS2	15:66	eco-friendly chitosan functionalized few-layered WS2	15:66	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	1	31	theme	broad	309:313	arg1	platform					324:331	a broad material platform	307:331	a broad material platform for building nano and atomic-level applications	307:379	The abundance of two-dimensional (2D) components has provided them with a broad material platform for building nano and atomic-level applications.
34480908	0	32	theme	anticancer	152:161	arg1	activity					163:170	in vitro antibacterial and anticancer activity	125:170	in vitro antibacterial and anticancer activity	125:170	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	8	33	dep	bacteria	1326:1333	arg1	coli					1320:1323	E. coli	1317:1323	E. coli	1317:1323	The CS/WS2/Ru composites exhibit significant antibacterial action towards (S. aureus, and E. coli) bacteria.
34480908	8	33	dep	bacteria	1326:1333	arg1	aureus					1305:1310	S. aureus	1302:1310	S. aureus	1302:1310	The CS/WS2/Ru composites exhibit significant antibacterial action towards (S. aureus, and E. coli) bacteria.
34480908	3	34	theme	conventional	490:501	arg1	graphene					476:483	graphene	476:483	graphene	476:483	Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community.
34480908	3	34	theme	conventional	490:501	arg1	element					514:520	a conventional 2D layered element	488:520	a conventional 2D layered element that has significant attention in the scientific community	488:579	Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community.
34480908	0	35	theme	eco-friendly	15:26	arg1	WS2					64:66	eco-friendly chitosan functionalized few-layered WS2	15:66	eco-friendly chitosan functionalized few-layered WS2	15:66	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	1	36	theme	material	315:322	arg1	platform					324:331	a broad material platform	307:331	a broad material platform for building nano and atomic-level applications	307:379	The abundance of two-dimensional (2D) components has provided them with a broad material platform for building nano and atomic-level applications.
34480908	3	37	theme	scientific	560:569	arg1	community					571:579	the scientific community	556:579	the scientific community	556:579	Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community.
34480908	10	38	from	aspects	1475:1481	arg1	applications					1524:1535	carcinological applications	1509:1535	carcinological applications	1509:1535	These reports are possible to explore the innovative aspects of biological outcomes in carcinological applications.
34480908	3	39	theme	2D	503:504	arg1	graphene					476:483	graphene	476:483	graphene	476:483	Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community.
34480908	3	39	theme	2D	503:504	arg1	element					514:520	a conventional 2D layered element	488:520	a conventional 2D layered element that has significant attention in the scientific community	488:579	Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community.
34480908	0	40	theme	few-layered	52:62	arg1	WS2					64:66	eco-friendly chitosan functionalized few-layered WS2	15:66	eco-friendly chitosan functionalized few-layered WS2	15:66	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	4	41	theme	numerous	598:605	arg1	nanomaterials					614:626	numerous new 2D nanomaterials	598:626	numerous new 2D nanomaterials other than graphene	598:646	In recent years numerous new 2D nanomaterials other than graphene have been reported.
34480908	7	42	theme	CS/WS2/Ru	1175:1183	arg1	composite					1185:1193	biologically active CS/WS2/Ru composite	1155:1193	biologically active CS/WS2/Ru composite	1155:1193	Herein, we synthesized biologically active CS/WS2/Ru composite by liquid exfoliation approach.
34480908	6	43	theme	exciting	1023:1030	arg1	groups					1032:1037	emerging and exciting groups	1010:1037	emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine	1010:1129	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	6	43	theme	exciting	1023:1030	arg1	elements					1042:1049	elements	1042:1049	elements with display great opportunities in several fields, such as cancer nanomedicine	1042:1129	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	0	44	dep	nanocomposite	68:80	arg1	implanted					82:90	implanted	82:90	nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications	68:232	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	6	45	theme	elements	1042:1049	arg1	groups					1032:1037	emerging and exciting groups	1010:1037	emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine	1010:1129	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	6	45	theme	elements	1042:1049	arg1	elements					1042:1049	elements	1042:1049	elements with display great opportunities in several fields, such as cancer nanomedicine	1042:1129	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	2	46	theme	properties	447:456	arg1	unique					407:412	unique	407:412	unique	407:412	So, 2D nanomaterials are unique because of their physicochemical properties.
34480908	0	47	theme	functionalized	37:50	arg1	WS2					64:66	eco-friendly chitosan functionalized few-layered WS2	15:66	eco-friendly chitosan functionalized few-layered WS2	15:66	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	5	48	theme	properties	806:815	arg1	explanation					774:784	the explanation	770:784	the explanation of special material properties	770:815	The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials.
34480908	5	49	theme	biological	860:869	arg1	applications					871:882	the biological applications	856:882	the biological applications of 2D nanomaterials	856:902	The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials.
34480908	1	50	theme	two-dimensional	252:266	arg1	components					273:282	two-dimensional (2D) components	252:282	two-dimensional (2D) components	252:282	The abundance of two-dimensional (2D) components has provided them with a broad material platform for building nano and atomic-level applications.
34480908	6	51	theme	metal	947:951	arg1	TMDCs					970:974	TMDCs	970:974	TMDCs	970:974	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	6	51	theme	metal	947:951	arg1	dichalcogenides					953:967	the transition metal dichalcogenides	932:967	the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine	932:1129	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	6	51	theme	metal	947:951	arg1	WS2					994:996	WS2	994:996	WS2	994:996	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	6	51	theme	metal	947:951	arg1	MoS2					985:988	MoS2	985:988	MoS2	985:988	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	4	52	theme	recent	585:590	arg1	years					592:596	recent years	585:596	recent years	585:596	In recent years numerous new 2D nanomaterials other than graphene have been reported.
34480908	6	53	theme	cancer	1111:1116	arg1	nanomedicine					1118:1129	cancer nanomedicine	1111:1129	cancer nanomedicine	1111:1129	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	0	54	theme	WS2	64:66	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of eco-friendly chitosan functionalized few-layered WS2	0:66	Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.
34480908	9	55	theme	synergetic	1365:1374	arg1	action					1387:1392	synergetic anticancer action	1365:1392	synergetic anticancer action against MCF-7 cancer cells	1365:1419	Also, the composite suggests synergetic anticancer action against MCF-7 cancer cells.
34480908	10	56	theme	carcinological	1509:1522	arg1	applications					1524:1535	carcinological applications	1509:1535	carcinological applications	1509:1535	These reports are possible to explore the innovative aspects of biological outcomes in carcinological applications.
34480908	7	57	theme	liquid	1198:1203	arg1	approach					1217:1224	liquid exfoliation approach	1198:1224	liquid exfoliation approach	1198:1224	Herein, we synthesized biologically active CS/WS2/Ru composite by liquid exfoliation approach.
34480908	9	58	theme	anticancer	1376:1385	arg1	action					1387:1392	synergetic anticancer action	1365:1392	synergetic anticancer action against MCF-7 cancer cells	1365:1419	Also, the composite suggests synergetic anticancer action against MCF-7 cancer cells.
34480908	5	59	theme	infant	713:718	arg1	stages					720:725	its infant stages	709:725	its infant stages	709:725	The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials.
34480908	8	60	theme	significant	1260:1270	arg1	action					1286:1291	significant antibacterial action	1260:1291	significant antibacterial action towards (S. aureus, and E. coli) bacteria	1260:1333	The CS/WS2/Ru composites exhibit significant antibacterial action towards (S. aureus, and E. coli) bacteria.
34480908	3	61	theme	layered	506:512	arg1	graphene					476:483	graphene	476:483	graphene	476:483	Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community.
34480908	3	61	theme	layered	506:512	arg1	element					514:520	a conventional 2D layered element	488:520	a conventional 2D layered element that has significant attention in the scientific community	488:579	Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community.
34480908	6	62	theme	emerging	1010:1017	arg1	groups					1032:1037	emerging and exciting groups	1010:1037	emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine	1010:1129	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	6	62	theme	emerging	1010:1017	arg1	elements					1042:1049	elements	1042:1049	elements with display great opportunities in several fields, such as cancer nanomedicine	1042:1129	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	1	63	dep	two-dimensional	252:266	arg1	2D					269:270	2D	269:270	2D	269:270	The abundance of two-dimensional (2D) components has provided them with a broad material platform for building nano and atomic-level applications.
34480908	2	64	theme	physicochemical	431:445	arg1	properties					447:456	their physicochemical properties	425:456	their physicochemical properties	425:456	So, 2D nanomaterials are unique because of their physicochemical properties.
34480908	6	65	from	opportunities	1070:1082	arg1	nanomedicine					1118:1129	cancer nanomedicine	1111:1129	cancer nanomedicine	1111:1129	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	6	65	from	opportunities	1070:1082	arg1	fields					1095:1100	several fields	1087:1100	several fields	1087:1100	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	8	66	theme	CS/WS2/Ru	1231:1239	arg1	composites					1241:1250	The CS/WS2/Ru composites	1227:1250	The CS/WS2/Ru composites	1227:1250	The CS/WS2/Ru composites exhibit significant antibacterial action towards (S. aureus, and E. coli) bacteria.
34480908	9	67	theme	MCF-7	1402:1406	arg1	cells					1415:1419	MCF-7 cancer cells	1402:1419	MCF-7 cancer cells	1402:1419	Also, the composite suggests synergetic anticancer action against MCF-7 cancer cells.
34480908	1	68	theme	atomic-level	355:366	arg1	applications					368:379	atomic-level applications	355:379	atomic-level applications	355:379	The abundance of two-dimensional (2D) components has provided them with a broad material platform for building nano and atomic-level applications.
34480908	9	69	theme	cancer	1408:1413	arg1	cells					1415:1419	MCF-7 cancer cells	1402:1419	MCF-7 cancer cells	1402:1419	Also, the composite suggests synergetic anticancer action against MCF-7 cancer cells.
34480908	6	70	theme	several	1087:1093	arg1	nanomedicine					1118:1129	cancer nanomedicine	1111:1129	cancer nanomedicine	1111:1129	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	6	70	theme	several	1087:1093	arg1	fields					1095:1100	several fields	1087:1100	several fields	1087:1100	As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine.
34480908	1	71	theme	components	273:282	arg1	abundance					239:247	The abundance	235:247	The abundance of two-dimensional (2D) components	235:282	The abundance of two-dimensional (2D) components has provided them with a broad material platform for building nano and atomic-level applications.
34740666	0	0	theme	fungal	89:94	arg1	communities					96:106	fungal communities	89:106	fungal communities during rice straw composting	89:135	Effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	1	1	theme	article	155:161	arg1	aims					142:145	The aims	138:145	The aims of this article	138:161	The aims of this article were to study the effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	7	2	theme	redundancy	1233:1242	arg1	analyses					1274:1281	redundancy and structural equation model analyses	1233:1281	redundancy and structural equation model analyses	1233:1281	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	5	3	from	modules	888:894	arg1	hosts					917:921	core hosts	912:921	core hosts of the cellulose-degrading genes driving the cellulosic degradation	912:989	In addition, a network analysis showed that in the FeWI treatment, the fungi from modules 1, 5 and 8 were core hosts of the cellulose-degrading genes driving the cellulosic degradation.
34740666	5	3	from	modules	888:894	arg1	fungi					877:881	the fungi	873:881	the fungi from modules 1, 5 and 8	873:905	In addition, a network analysis showed that in the FeWI treatment, the fungi from modules 1, 5 and 8 were core hosts of the cellulose-degrading genes driving the cellulosic degradation.
34740666	4	4	theme	fungal	690:695	arg1	composition					709:719	the fungal communities composition	686:719	the fungal communities composition	686:719	The results indicated that Fenton pretreatment and bacterial inoculation changed the fungal communities composition and increased fungal diversity, leading to changes in the cellulose-degrading genes.
34740666	0	5	from	Effect	0:5	arg1	genes					79:83	cellulose-degrading genes	59:83	cellulose-degrading genes	59:83	Effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	0	5	from	Effect	0:5	arg1	communities					96:106	fungal communities	89:106	fungal communities during rice straw composting	89:135	Effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	7	6	theme	Shannon	1308:1314	arg1	index					1316:1320	the NH4+-N, TOC, pH and Shannon index	1284:1320	the NH4+-N, TOC, pH and Shannon index	1284:1320	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	7	6	theme	Shannon	1308:1314	arg1	factors					1337:1343	important factors	1327:1343	important factors influencing the variations in the cellulose-degrading genes	1327:1403	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	8	7	theme	cellulosic	1443:1452	arg1	degradation					1454:1464	cellulosic degradation	1443:1464	cellulosic degradation	1443:1464	This study provides a foundation for cellulosic degradation during cellulosic waste composting.
34740666	1	8	theme	fungal	270:275	arg1	communities					277:287	fungal communities	270:287	fungal communities	270:287	The aims of this article were to study the effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	6	9	theme	cellulose-degrading	1155:1173	arg1	genes					1175:1179	the cellulose-degrading genes	1151:1179	the cellulose-degrading genes	1151:1179	Moreover, Fenton pretreatment and bacterial inoculation changed the core module fungal communities and strengthened the correlation between the core fungi and the cellulose-degrading genes, thereby promoting cellulosic degradation.
34740666	5	10	theme	cellulose-degrading	930:948	arg1	genes					950:954	the cellulose-degrading genes	926:954	the cellulose-degrading genes driving the cellulosic degradation	926:989	In addition, a network analysis showed that in the FeWI treatment, the fungi from modules 1, 5 and 8 were core hosts of the cellulose-degrading genes driving the cellulosic degradation.
34740666	4	11	theme	communities	697:707	arg1	composition					709:719	the fungal communities composition	686:719	the fungal communities composition	686:719	The results indicated that Fenton pretreatment and bacterial inoculation changed the fungal communities composition and increased fungal diversity, leading to changes in the cellulose-degrading genes.
34740666	0	12	theme	straw	120:124	arg1	composting					126:135	rice straw composting	115:135	rice straw composting	115:135	Effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	6	13	theme	core	1136:1139	arg1	fungi					1141:1145	the core fungi	1132:1145	the core fungi	1132:1145	Moreover, Fenton pretreatment and bacterial inoculation changed the core module fungal communities and strengthened the correlation between the core fungi and the cellulose-degrading genes, thereby promoting cellulosic degradation.
34740666	5	14	theme	core	912:915	arg1	hosts					917:921	core hosts	912:921	core hosts of the cellulose-degrading genes driving the cellulosic degradation	912:989	In addition, a network analysis showed that in the FeWI treatment, the fungi from modules 1, 5 and 8 were core hosts of the cellulose-degrading genes driving the cellulosic degradation.
34740666	5	14	theme	core	912:915	arg1	fungi					877:881	the fungi	873:881	the fungi from modules 1, 5 and 8	873:905	In addition, a network analysis showed that in the FeWI treatment, the fungi from modules 1, 5 and 8 were core hosts of the cellulose-degrading genes driving the cellulosic degradation.
34740666	2	15	theme	cooling	433:439	arg1	phase					441:445	the cooling phase	429:445	the cooling phase of composting	429:459	The rice straw was pretreated by Fenton reactions and functional bacterial agents were then inoculated during the cooling phase of composting.
34740666	3	16	theme	Fenton	521:526	arg1	pretreatment					528:539	Fenton pretreatment	521:539	Fenton pretreatment (FeW)	521:545	Three treatment groups were carried out, the control (CK), Fenton pretreatment (FeW) and Fenton pretreatment and bacterial inoculation (FeWI).
34740666	6	17	theme	core	1060:1063	arg1	communities					1079:1089	the core module fungal communities	1056:1089	the core module fungal communities	1056:1089	Moreover, Fenton pretreatment and bacterial inoculation changed the core module fungal communities and strengthened the correlation between the core fungi and the cellulose-degrading genes, thereby promoting cellulosic degradation.
34740666	5	18	theme	FeWI	857:860	arg1	treatment					862:870	the FeWI treatment	853:870	the FeWI treatment	853:870	In addition, a network analysis showed that in the FeWI treatment, the fungi from modules 1, 5 and 8 were core hosts of the cellulose-degrading genes driving the cellulosic degradation.
34740666	0	19	theme	rice	115:118	arg1	composting					126:135	rice straw composting	115:135	rice straw composting	115:135	Effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	6	20	theme	Fenton	1002:1007	arg1	pretreatment					1009:1020	Fenton pretreatment	1002:1020	Fenton pretreatment	1002:1020	Moreover, Fenton pretreatment and bacterial inoculation changed the core module fungal communities and strengthened the correlation between the core fungi and the cellulose-degrading genes, thereby promoting cellulosic degradation.
34740666	7	21	from	variations	1361:1370	arg1	genes					1399:1403	the cellulose-degrading genes	1375:1403	the cellulose-degrading genes	1375:1403	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	6	22	theme	module	1065:1070	arg1	communities					1079:1089	the core module fungal communities	1056:1089	the core module fungal communities	1056:1089	Moreover, Fenton pretreatment and bacterial inoculation changed the core module fungal communities and strengthened the correlation between the core fungi and the cellulose-degrading genes, thereby promoting cellulosic degradation.
34740666	3	23	theme	Fenton	551:556	arg1	FeWI					598:601	FeWI	598:601	FeWI	598:601	Three treatment groups were carried out, the control (CK), Fenton pretreatment (FeW) and Fenton pretreatment and bacterial inoculation (FeWI).
34740666	3	23	theme	Fenton	551:556	arg1	pretreatment					558:569	Fenton pretreatment	551:569	Fenton pretreatment	551:569	Three treatment groups were carried out, the control (CK), Fenton pretreatment (FeW) and Fenton pretreatment and bacterial inoculation (FeWI).
34740666	4	24	theme	Fenton	632:637	arg1	pretreatment					639:650	Fenton pretreatment	632:650	Fenton pretreatment	632:650	The results indicated that Fenton pretreatment and bacterial inoculation changed the fungal communities composition and increased fungal diversity, leading to changes in the cellulose-degrading genes.
34740666	2	25	theme	rice	323:326	arg1	straw					328:332	The rice straw	319:332	The rice straw	319:332	The rice straw was pretreated by Fenton reactions and functional bacterial agents were then inoculated during the cooling phase of composting.
34740666	4	26	theme	bacterial	656:664	arg1	inoculation					666:676	bacterial inoculation	656:676	bacterial inoculation	656:676	The results indicated that Fenton pretreatment and bacterial inoculation changed the fungal communities composition and increased fungal diversity, leading to changes in the cellulose-degrading genes.
34740666	2	27	theme	composting	450:459	arg1	phase					441:445	the cooling phase	429:445	the cooling phase of composting	429:459	The rice straw was pretreated by Fenton reactions and functional bacterial agents were then inoculated during the cooling phase of composting.
34740666	1	28	theme	rice	296:299	arg1	composting					307:316	rice straw composting	296:316	rice straw composting	296:316	The aims of this article were to study the effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	8	29	theme	waste	1484:1488	arg1	composting					1490:1499	cellulosic waste composting	1473:1499	cellulosic waste composting	1473:1499	This study provides a foundation for cellulosic degradation during cellulosic waste composting.
34740666	4	30	from	changes	764:770	arg1	genes					799:803	the cellulose-degrading genes	775:803	the cellulose-degrading genes	775:803	The results indicated that Fenton pretreatment and bacterial inoculation changed the fungal communities composition and increased fungal diversity, leading to changes in the cellulose-degrading genes.
34740666	6	31	theme	bacterial	1026:1034	arg1	inoculation					1036:1046	bacterial inoculation	1026:1046	bacterial inoculation	1026:1046	Moreover, Fenton pretreatment and bacterial inoculation changed the core module fungal communities and strengthened the correlation between the core fungi and the cellulose-degrading genes, thereby promoting cellulosic degradation.
34740666	0	32	theme	Fenton	10:15	arg1	pretreatment					17:28	Fenton pretreatment	10:28	Fenton pretreatment	10:28	Effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	1	33	theme	straw	301:305	arg1	composting					307:316	rice straw composting	296:316	rice straw composting	296:316	The aims of this article were to study the effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	4	34	theme	cellulose-degrading	779:797	arg1	genes					799:803	the cellulose-degrading genes	775:803	the cellulose-degrading genes	775:803	The results indicated that Fenton pretreatment and bacterial inoculation changed the fungal communities composition and increased fungal diversity, leading to changes in the cellulose-degrading genes.
34740666	8	35	theme	cellulosic	1473:1482	arg1	composting					1490:1499	cellulosic waste composting	1473:1499	cellulosic waste composting	1473:1499	This study provides a foundation for cellulosic degradation during cellulosic waste composting.
34740666	7	36	theme	model	1268:1272	arg1	analyses					1274:1281	redundancy and structural equation model analyses	1233:1281	redundancy and structural equation model analyses	1233:1281	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	1	37	theme	Fenton	191:196	arg1	pretreatment					198:209	Fenton pretreatment	191:209	Fenton pretreatment	191:209	The aims of this article were to study the effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	0	38	theme	bacterial	34:42	arg1	inoculation					44:54	bacterial inoculation	34:54	bacterial inoculation	34:54	Effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	7	39	theme	TOC	1296:1298	arg1	index					1316:1320	the NH4+-N, TOC, pH and Shannon index	1284:1320	the NH4+-N, TOC, pH and Shannon index	1284:1320	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	7	39	theme	TOC	1296:1298	arg1	factors					1337:1343	important factors	1327:1343	important factors influencing the variations in the cellulose-degrading genes	1327:1403	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	3	40	theme	treatment	468:476	arg1	groups					478:483	Three treatment groups	462:483	Three treatment groups	462:483	Three treatment groups were carried out, the control (CK), Fenton pretreatment (FeW) and Fenton pretreatment and bacterial inoculation (FeWI).
34740666	7	41	theme	pH	1301:1302	arg1	index					1316:1320	the NH4+-N, TOC, pH and Shannon index	1284:1320	the NH4+-N, TOC, pH and Shannon index	1284:1320	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	7	41	theme	pH	1301:1302	arg1	factors					1337:1343	important factors	1327:1343	important factors influencing the variations in the cellulose-degrading genes	1327:1403	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	1	42	theme	pretreatment	198:209	arg1	effect					181:186	the effect	177:186	the effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities	177:287	The aims of this article were to study the effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	6	43	theme	fungal	1072:1077	arg1	communities					1079:1089	the core module fungal communities	1056:1089	the core module fungal communities	1056:1089	Moreover, Fenton pretreatment and bacterial inoculation changed the core module fungal communities and strengthened the correlation between the core fungi and the cellulose-degrading genes, thereby promoting cellulosic degradation.
34740666	7	44	theme	important	1327:1335	arg1	index					1316:1320	the NH4+-N, TOC, pH and Shannon index	1284:1320	the NH4+-N, TOC, pH and Shannon index	1284:1320	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	7	44	theme	important	1327:1335	arg1	factors					1337:1343	important factors	1327:1343	important factors influencing the variations in the cellulose-degrading genes	1327:1403	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	0	45	theme	pretreatment	17:28	arg1	Effect					0:5	Effect	0:5	Effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.	0:136	Effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	7	46	theme	cellulose-degrading	1379:1397	arg1	genes					1399:1403	the cellulose-degrading genes	1375:1403	the cellulose-degrading genes	1375:1403	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	5	47	theme	network	821:827	arg1	analysis					829:836	a network analysis	819:836	a network analysis	819:836	In addition, a network analysis showed that in the FeWI treatment, the fungi from modules 1, 5 and 8 were core hosts of the cellulose-degrading genes driving the cellulosic degradation.
34740666	7	48	theme	structural	1248:1257	arg1	model					1268:1272	structural equation model	1248:1272	structural equation model	1248:1272	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	2	49	theme	Fenton	352:357	arg1	reactions					359:367	Fenton reactions	352:367	Fenton reactions	352:367	The rice straw was pretreated by Fenton reactions and functional bacterial agents were then inoculated during the cooling phase of composting.
34740666	0	50	theme	inoculation	44:54	arg1	Effect					0:5	Effect	0:5	Effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.	0:136	Effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	3	51	theme	bacterial	575:583	arg1	inoculation					585:595	bacterial inoculation	575:595	bacterial inoculation	575:595	Three treatment groups were carried out, the control (CK), Fenton pretreatment (FeW) and Fenton pretreatment and bacterial inoculation (FeWI).
34740666	3	52	dep	pretreatment	528:539	arg1	FeW					542:544	FeW	542:544	FeW	542:544	Three treatment groups were carried out, the control (CK), Fenton pretreatment (FeW) and Fenton pretreatment and bacterial inoculation (FeWI).
34740666	5	53	from	hosts	917:921	arg1	treatment					862:870	the FeWI treatment	853:870	the FeWI treatment	853:870	In addition, a network analysis showed that in the FeWI treatment, the fungi from modules 1, 5 and 8 were core hosts of the cellulose-degrading genes driving the cellulosic degradation.
34740666	6	54	theme	cellulosic	1200:1209	arg1	degradation					1211:1221	cellulosic degradation	1200:1221	cellulosic degradation	1200:1221	Moreover, Fenton pretreatment and bacterial inoculation changed the core module fungal communities and strengthened the correlation between the core fungi and the cellulose-degrading genes, thereby promoting cellulosic degradation.
34740666	4	55	theme	fungal	735:740	arg1	diversity					742:750	fungal diversity	735:750	fungal diversity	735:750	The results indicated that Fenton pretreatment and bacterial inoculation changed the fungal communities composition and increased fungal diversity, leading to changes in the cellulose-degrading genes.
34740666	1	56	theme	bacterial	215:223	arg1	inoculation					225:235	bacterial inoculation	215:235	bacterial inoculation	215:235	The aims of this article were to study the effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	5	57	theme	cellulosic	968:977	arg1	degradation					979:989	the cellulosic degradation	964:989	the cellulosic degradation	964:989	In addition, a network analysis showed that in the FeWI treatment, the fungi from modules 1, 5 and 8 were core hosts of the cellulose-degrading genes driving the cellulosic degradation.
34740666	7	58	theme	NH4+-N	1288:1293	arg1	index					1316:1320	the NH4+-N, TOC, pH and Shannon index	1284:1320	the NH4+-N, TOC, pH and Shannon index	1284:1320	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	7	58	theme	NH4+-N	1288:1293	arg1	factors					1337:1343	important factors	1327:1343	important factors influencing the variations in the cellulose-degrading genes	1327:1403	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	1	59	theme	inoculation	225:235	arg1	effect					181:186	the effect	177:186	the effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities	177:287	The aims of this article were to study the effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	5	60	theme	genes	950:954	arg1	hosts					917:921	core hosts	912:921	core hosts of the cellulose-degrading genes driving the cellulosic degradation	912:989	In addition, a network analysis showed that in the FeWI treatment, the fungi from modules 1, 5 and 8 were core hosts of the cellulose-degrading genes driving the cellulosic degradation.
34740666	5	60	theme	genes	950:954	arg1	fungi					877:881	the fungi	873:881	the fungi from modules 1, 5 and 8	873:905	In addition, a network analysis showed that in the FeWI treatment, the fungi from modules 1, 5 and 8 were core hosts of the cellulose-degrading genes driving the cellulosic degradation.
34740666	1	61	from	effect	181:186	arg1	genes					260:264	cellulose-degrading genes	240:264	cellulose-degrading genes	240:264	The aims of this article were to study the effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	1	61	from	effect	181:186	arg1	communities					277:287	fungal communities	270:287	fungal communities	270:287	The aims of this article were to study the effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	2	62	theme	bacterial	384:392	arg1	agents					394:399	functional bacterial agents	373:399	functional bacterial agents	373:399	The rice straw was pretreated by Fenton reactions and functional bacterial agents were then inoculated during the cooling phase of composting.
34740666	0	63	theme	cellulose-degrading	59:77	arg1	genes					79:83	cellulose-degrading genes	59:83	cellulose-degrading genes	59:83	Effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
34740666	3	64	dep	carried	490:496	arg1	out					498:500	out	498:500	out	498:500	Three treatment groups were carried out, the control (CK), Fenton pretreatment (FeW) and Fenton pretreatment and bacterial inoculation (FeWI).
34740666	2	65	theme	functional	373:382	arg1	agents					394:399	functional bacterial agents	373:399	functional bacterial agents	373:399	The rice straw was pretreated by Fenton reactions and functional bacterial agents were then inoculated during the cooling phase of composting.
34740666	7	66	theme	equation	1259:1266	arg1	model					1268:1272	structural equation model	1248:1272	structural equation model	1248:1272	Based on redundancy and structural equation model analyses, the NH4+-N, TOC, pH and Shannon index were important factors influencing the variations in the cellulose-degrading genes.
34740666	1	67	theme	cellulose-degrading	240:258	arg1	genes					260:264	cellulose-degrading genes	240:264	cellulose-degrading genes	240:264	The aims of this article were to study the effect of Fenton pretreatment and bacterial inoculation on cellulose-degrading genes and fungal communities during rice straw composting.
33038401	0	0	theme	composite	76:84	arg1	study					21:25	In vitro and in vivo study	0:25	In vitro and in vivo study of naturally derived alginate/hydroxyapatite bio composite	0:84	In vitro and in vivo study of naturally derived alginate/hydroxyapatite bio composite scaffolds.
33038401	3	1	theme	porous	351:356	arg1	bHA					383:385	porous biogenic hydroxyapatite (bHA)	351:386	porous biogenic hydroxyapatite (bHA)	351:386	In the present study, porous biogenic hydroxyapatite (bHA) was prepared via a polymeric infiltration route and was subsequently coated with alginate to produce alginate/biogenic hydroxyapatite (Alg/bHA) composites.
33038401	5	2	theme	%	682:682	arg1	alginate					687:694	3%w/v alginate	681:694	3%w/v alginate applied for 10 min	681:713	A coating of 3%w/v alginate applied for 10 min was found to result in the best coating for the HA porous scaffolds.
33038401	7	3	theme	endochondral	1019:1030	arg1	formation					1057:1065	both endochondral and intramembranous bone formation	1014:1065	both endochondral and intramembranous bone formation	1014:1065	The histological study in femur bone of rats indicated that the 3Alg/HA scaffolds capable of supporting both endochondral and intramembranous bone formation.
33038401	1	4	theme	bone	169:172	arg1	applications					186:197	bone restoration applications	169:197	bone restoration applications	169:197	Biogenic bioceramics scaffolds are receiving considerable attention for bone restoration applications.
33038401	10	5	theme	engineering	1484:1494	arg1	applications					1496:1507	the tissue engineering applications	1473:1507	the tissue engineering applications	1473:1507	Accordingly, 3Alg/HA scaffolds are recommended for the tissue engineering applications.
33038401	0	6	theme	bio	72:74	arg1	composite					76:84	naturally derived alginate/hydroxyapatite bio composite	30:84	naturally derived alginate/hydroxyapatite bio composite	30:84	In vitro and in vivo study of naturally derived alginate/hydroxyapatite bio composite scaffolds.
33038401	5	7	theme	w/v	683:685	arg1	alginate					687:694	3%w/v alginate	681:694	3%w/v alginate applied for 10 min	681:713	A coating of 3%w/v alginate applied for 10 min was found to result in the best coating for the HA porous scaffolds.
33038401	6	8	theme	prepared	825:832	arg1	composites					834:843	the prepared composites	821:843	the prepared composites	821:843	The in vitro study demonstrated that the prepared composites had acceptable bioactivity and biodegradability characteristics.
33038401	1	9	theme	restoration	174:184	arg1	applications					186:197	bone restoration applications	169:197	bone restoration applications	169:197	Biogenic bioceramics scaffolds are receiving considerable attention for bone restoration applications.
33038401	10	10	theme	tissue	1477:1482	arg1	applications					1496:1507	the tissue engineering applications	1473:1507	the tissue engineering applications	1473:1507	Accordingly, 3Alg/HA scaffolds are recommended for the tissue engineering applications.
33038401	5	11	theme	best	742:745	arg1	coating					747:753	the best coating	738:753	the best coating for the HA porous scaffolds	738:781	A coating of 3%w/v alginate applied for 10 min was found to result in the best coating for the HA porous scaffolds.
33038401	5	12	theme	alginate	687:694	arg1	coating					670:676	A coating	668:676	A coating of 3%w/v alginate applied for 10 min	668:713	A coating of 3%w/v alginate applied for 10 min was found to result in the best coating for the HA porous scaffolds.
33038401	3	13	theme	infiltration	417:428	arg1	route					430:434	a polymeric infiltration route	405:434	a polymeric infiltration route	405:434	In the present study, porous biogenic hydroxyapatite (bHA) was prepared via a polymeric infiltration route and was subsequently coated with alginate to produce alginate/biogenic hydroxyapatite (Alg/bHA) composites.
33038401	7	14	theme	histological	914:925	arg1	study					927:931	The histological study	910:931	The histological study in femur bone of rats	910:953	The histological study in femur bone of rats indicated that the 3Alg/HA scaffolds capable of supporting both endochondral and intramembranous bone formation.
33038401	4	15	theme	mechanical	577:586	arg1	properties					588:597	the mechanical properties	573:597	the mechanical properties as well as the bioactivity and biodegradability of the HA scaffolds	573:665	Alginate was used to enhance the mechanical properties as well as the bioactivity and biodegradability of the HA scaffolds.
33038401	6	16	dep	in	788:789	arg1	vitro					791:795	vitro	791:795	vitro	791:795	The in vitro study demonstrated that the prepared composites had acceptable bioactivity and biodegradability characteristics.
33038401	8	17	theme	Ca/P	1170:1173	arg1	ratio					1182:1186	Ca/P atomic ratio	1170:1186	Ca/P atomic ratio similar to the rat's normal bone	1170:1219	The defect was fully regenerated and mostly filled with the mature lamellar bone after 6 months, with Ca/P atomic ratio similar to the rat's normal bone.
33038401	7	18	from	study	927:931	arg1	bone					942:945	femur bone	936:945	femur bone of rats	936:953	The histological study in femur bone of rats indicated that the 3Alg/HA scaffolds capable of supporting both endochondral and intramembranous bone formation.
33038401	9	19	theme	studied	1226:1232	arg1	scaffolds					1234:1242	The studied scaffolds	1222:1242	The studied scaffolds	1222:1242	The studied scaffolds provide a promising therapeutic option to enhance local bone healing because they do not damage liver or kidney functions and do not induce carcinogenic or inflammatory effects.
33038401	2	20	theme	bioactive	309:317	arg1	features					319:326	enhanced bioactive features	300:326	enhanced bioactive features	300:326	Compared with scaffolds of chemical origin, biogenic scaffolds exhibit greater biocompatibility and enhanced bioactive features.
33038401	5	21	theme	porous	766:771	arg1	scaffolds					773:781	the HA porous scaffolds	759:781	the HA porous scaffolds	759:781	A coating of 3%w/v alginate applied for 10 min was found to result in the best coating for the HA porous scaffolds.
33038401	3	22	theme	polymeric	407:415	arg1	route					430:434	a polymeric infiltration route	405:434	a polymeric infiltration route	405:434	In the present study, porous biogenic hydroxyapatite (bHA) was prepared via a polymeric infiltration route and was subsequently coated with alginate to produce alginate/biogenic hydroxyapatite (Alg/bHA) composites.
33038401	3	23	theme	biogenic	358:365	arg1	bHA					383:385	porous biogenic hydroxyapatite (bHA)	351:386	porous biogenic hydroxyapatite (bHA)	351:386	In the present study, porous biogenic hydroxyapatite (bHA) was prepared via a polymeric infiltration route and was subsequently coated with alginate to produce alginate/biogenic hydroxyapatite (Alg/bHA) composites.
33038401	3	24	theme	hydroxyapatite	367:380	arg1	bHA					383:385	porous biogenic hydroxyapatite (bHA)	351:386	porous biogenic hydroxyapatite (bHA)	351:386	In the present study, porous biogenic hydroxyapatite (bHA) was prepared via a polymeric infiltration route and was subsequently coated with alginate to produce alginate/biogenic hydroxyapatite (Alg/bHA) composites.
33038401	0	25	theme	In	0:1	arg1	study					21:25	In vitro and in vivo study	0:25	In vitro and in vivo study of naturally derived alginate/hydroxyapatite bio composite	0:84	In vitro and in vivo study of naturally derived alginate/hydroxyapatite bio composite scaffolds.
33038401	5	26	theme	3	681:681	arg1	%					682:682	%	682:682	%	682:682	A coating of 3%w/v alginate applied for 10 min was found to result in the best coating for the HA porous scaffolds.
33038401	6	27	theme	in	788:789	arg1	study					797:801	The in vitro study	784:801	The in vitro study	784:801	The in vitro study demonstrated that the prepared composites had acceptable bioactivity and biodegradability characteristics.
33038401	8	28	theme	similar	1188:1194	arg1	ratio					1182:1186	Ca/P atomic ratio	1170:1186	Ca/P atomic ratio similar to the rat's normal bone	1170:1219	The defect was fully regenerated and mostly filled with the mature lamellar bone after 6 months, with Ca/P atomic ratio similar to the rat's normal bone.
33038401	9	29	dep	liver	1340:1344	arg1	functions					1356:1364	functions	1356:1364	functions	1356:1364	The studied scaffolds provide a promising therapeutic option to enhance local bone healing because they do not damage liver or kidney functions and do not induce carcinogenic or inflammatory effects.
33038401	0	30	theme	in	13:14	arg1	study					21:25	In vitro and in vivo study	0:25	In vitro and in vivo study of naturally derived alginate/hydroxyapatite bio composite	0:84	In vitro and in vivo study of naturally derived alginate/hydroxyapatite bio composite scaffolds.
33038401	8	31	theme	mature	1128:1133	arg1	bone					1144:1147	the mature lamellar bone	1124:1147	the mature lamellar bone after 6 months	1124:1162	The defect was fully regenerated and mostly filled with the mature lamellar bone after 6 months, with Ca/P atomic ratio similar to the rat's normal bone.
33038401	10	32	theme	3Alg/HA	1435:1441	arg1	scaffolds					1443:1451	3Alg/HA scaffolds	1435:1451	3Alg/HA scaffolds	1435:1451	Accordingly, 3Alg/HA scaffolds are recommended for the tissue engineering applications.
33038401	1	33	theme	Biogenic	97:104	arg1	scaffolds					118:126	Biogenic bioceramics scaffolds	97:126	Biogenic bioceramics scaffolds	97:126	Biogenic bioceramics scaffolds are receiving considerable attention for bone restoration applications.
33038401	9	34	theme	inflammatory	1400:1411	arg1	effects					1413:1419	carcinogenic or inflammatory effects	1384:1419	carcinogenic or inflammatory effects	1384:1419	The studied scaffolds provide a promising therapeutic option to enhance local bone healing because they do not damage liver or kidney functions and do not induce carcinogenic or inflammatory effects.
33038401	3	35	theme	hydroxyapatite	507:520	arg1	composites					532:541	alginate/biogenic hydroxyapatite (Alg/bHA) composites	489:541	alginate/biogenic hydroxyapatite (Alg/bHA) composites	489:541	In the present study, porous biogenic hydroxyapatite (bHA) was prepared via a polymeric infiltration route and was subsequently coated with alginate to produce alginate/biogenic hydroxyapatite (Alg/bHA) composites.
33038401	8	36	theme	atomic	1175:1180	arg1	ratio					1182:1186	Ca/P atomic ratio	1170:1186	Ca/P atomic ratio similar to the rat's normal bone	1170:1219	The defect was fully regenerated and mostly filled with the mature lamellar bone after 6 months, with Ca/P atomic ratio similar to the rat's normal bone.
33038401	9	37	theme	promising	1254:1262	arg1	option					1276:1281	a promising therapeutic option	1252:1281	a promising therapeutic option to enhance local bone healing because they do not damage liver or kidney functions and do not induce carcinogenic or inflammatory effects	1252:1419	The studied scaffolds provide a promising therapeutic option to enhance local bone healing because they do not damage liver or kidney functions and do not induce carcinogenic or inflammatory effects.
33038401	1	38	theme	bioceramics	106:116	arg1	scaffolds					118:126	Biogenic bioceramics scaffolds	97:126	Biogenic bioceramics scaffolds	97:126	Biogenic bioceramics scaffolds are receiving considerable attention for bone restoration applications.
33038401	9	39	theme	therapeutic	1264:1274	arg1	option					1276:1281	a promising therapeutic option	1252:1281	a promising therapeutic option to enhance local bone healing because they do not damage liver or kidney functions and do not induce carcinogenic or inflammatory effects	1252:1419	The studied scaffolds provide a promising therapeutic option to enhance local bone healing because they do not damage liver or kidney functions and do not induce carcinogenic or inflammatory effects.
33038401	5	40	theme	HA	763:764	arg1	scaffolds					773:781	the HA porous scaffolds	759:781	the HA porous scaffolds	759:781	A coating of 3%w/v alginate applied for 10 min was found to result in the best coating for the HA porous scaffolds.
33038401	8	41	theme	lamellar	1135:1142	arg1	bone					1144:1147	the mature lamellar bone	1124:1147	the mature lamellar bone after 6 months	1124:1162	The defect was fully regenerated and mostly filled with the mature lamellar bone after 6 months, with Ca/P atomic ratio similar to the rat's normal bone.
33038401	6	42	theme	biodegradability	876:891	arg1	characteristics					893:907	biodegradability characteristics	876:907	biodegradability characteristics	876:907	The in vitro study demonstrated that the prepared composites had acceptable bioactivity and biodegradability characteristics.
33038401	3	43	theme	alginate/biogenic	489:505	arg1	composites					532:541	alginate/biogenic hydroxyapatite (Alg/bHA) composites	489:541	alginate/biogenic hydroxyapatite (Alg/bHA) composites	489:541	In the present study, porous biogenic hydroxyapatite (bHA) was prepared via a polymeric infiltration route and was subsequently coated with alginate to produce alginate/biogenic hydroxyapatite (Alg/bHA) composites.
33038401	9	44	theme	carcinogenic	1384:1395	arg1	effects					1413:1419	carcinogenic or inflammatory effects	1384:1419	carcinogenic or inflammatory effects	1384:1419	The studied scaffolds provide a promising therapeutic option to enhance local bone healing because they do not damage liver or kidney functions and do not induce carcinogenic or inflammatory effects.
33038401	4	45	dep	bioactivity	614:624	arg1	the					610:612	the	610:612	the	610:612	Alginate was used to enhance the mechanical properties as well as the bioactivity and biodegradability of the HA scaffolds.
33038401	2	46	theme	biogenic	244:251	arg1	scaffolds					253:261	biogenic scaffolds	244:261	biogenic scaffolds	244:261	Compared with scaffolds of chemical origin, biogenic scaffolds exhibit greater biocompatibility and enhanced bioactive features.
33038401	6	47	contain	had	845:847	arg1	composites					834:843	the prepared composites	821:843	the prepared composites	821:843	The in vitro study demonstrated that the prepared composites had acceptable bioactivity and biodegradability characteristics.
33038401	6	47	contain	had	845:847	arg2	characteristics					893:907	biodegradability characteristics	876:907	biodegradability characteristics	876:907	The in vitro study demonstrated that the prepared composites had acceptable bioactivity and biodegradability characteristics.
33038401	6	47	contain	had	845:847	arg2	bioactivity					860:870	acceptable bioactivity	849:870	acceptable bioactivity	849:870	The in vitro study demonstrated that the prepared composites had acceptable bioactivity and biodegradability characteristics.
33038401	6	48	theme	acceptable	849:858	arg1	bioactivity					860:870	acceptable bioactivity	849:870	acceptable bioactivity	849:870	The in vitro study demonstrated that the prepared composites had acceptable bioactivity and biodegradability characteristics.
33038401	2	49	theme	origin	236:241	arg1	scaffolds					214:222	scaffolds	214:222	scaffolds of chemical origin	214:241	Compared with scaffolds of chemical origin, biogenic scaffolds exhibit greater biocompatibility and enhanced bioactive features.
33038401	2	50	theme	chemical	227:234	arg1	origin					236:241	chemical origin	227:241	chemical origin	227:241	Compared with scaffolds of chemical origin, biogenic scaffolds exhibit greater biocompatibility and enhanced bioactive features.
33038401	7	51	theme	bone	1052:1055	arg1	formation					1057:1065	both endochondral and intramembranous bone formation	1014:1065	both endochondral and intramembranous bone formation	1014:1065	The histological study in femur bone of rats indicated that the 3Alg/HA scaffolds capable of supporting both endochondral and intramembranous bone formation.
33038401	0	52	dep	In	0:1	arg1	vitro					3:7	vitro	3:7	vitro	3:7	In vitro and in vivo study of naturally derived alginate/hydroxyapatite bio composite scaffolds.
33038401	0	53	dep	in	13:14	arg1	vivo					16:19	vivo	16:19	vivo	16:19	In vitro and in vivo study of naturally derived alginate/hydroxyapatite bio composite scaffolds.
33038401	2	54	theme	enhanced	300:307	arg1	features					319:326	enhanced bioactive features	300:326	enhanced bioactive features	300:326	Compared with scaffolds of chemical origin, biogenic scaffolds exhibit greater biocompatibility and enhanced bioactive features.
33038401	0	55	link	derived	40:46	arg1	composite					76:84	naturally derived alginate/hydroxyapatite bio composite	30:84	naturally derived alginate/hydroxyapatite bio composite	30:84	In vitro and in vivo study of naturally derived alginate/hydroxyapatite bio composite scaffolds.
33038401	3	56	theme	Alg/bHA	523:529	arg1	composites					532:541	alginate/biogenic hydroxyapatite (Alg/bHA) composites	489:541	alginate/biogenic hydroxyapatite (Alg/bHA) composites	489:541	In the present study, porous biogenic hydroxyapatite (bHA) was prepared via a polymeric infiltration route and was subsequently coated with alginate to produce alginate/biogenic hydroxyapatite (Alg/bHA) composites.
33038401	7	57	theme	rats	950:953	arg1	bone					942:945	femur bone	936:945	femur bone of rats	936:953	The histological study in femur bone of rats indicated that the 3Alg/HA scaffolds capable of supporting both endochondral and intramembranous bone formation.
33038401	4	58	theme	HA	654:655	arg1	scaffolds					657:665	the HA scaffolds	650:665	the HA scaffolds	650:665	Alginate was used to enhance the mechanical properties as well as the bioactivity and biodegradability of the HA scaffolds.
33038401	3	59	theme	present	336:342	arg1	study					344:348	the present study	332:348	the present study	332:348	In the present study, porous biogenic hydroxyapatite (bHA) was prepared via a polymeric infiltration route and was subsequently coated with alginate to produce alginate/biogenic hydroxyapatite (Alg/bHA) composites.
33038401	9	60	theme	bone	1300:1303	arg1	healing					1305:1311	local bone healing	1294:1311	local bone healing	1294:1311	The studied scaffolds provide a promising therapeutic option to enhance local bone healing because they do not damage liver or kidney functions and do not induce carcinogenic or inflammatory effects.
33038401	8	61	theme	normal	1209:1214	arg1	bone					1216:1219	the rat's normal bone	1199:1219	the rat's normal bone	1199:1219	The defect was fully regenerated and mostly filled with the mature lamellar bone after 6 months, with Ca/P atomic ratio similar to the rat's normal bone.
33038401	1	62	theme	considerable	142:153	arg1	attention					155:163	considerable attention	142:163	considerable attention	142:163	Biogenic bioceramics scaffolds are receiving considerable attention for bone restoration applications.
33038401	7	63	theme	femur	936:940	arg1	bone					942:945	femur bone	936:945	femur bone of rats	936:953	The histological study in femur bone of rats indicated that the 3Alg/HA scaffolds capable of supporting both endochondral and intramembranous bone formation.
33038401	0	64	theme	alginate/hydroxyapatite	48:70	arg1	composite					76:84	naturally derived alginate/hydroxyapatite bio composite	30:84	naturally derived alginate/hydroxyapatite bio composite	30:84	In vitro and in vivo study of naturally derived alginate/hydroxyapatite bio composite scaffolds.
33038401	7	65	theme	intramembranous	1036:1050	arg1	formation					1057:1065	both endochondral and intramembranous bone formation	1014:1065	both endochondral and intramembranous bone formation	1014:1065	The histological study in femur bone of rats indicated that the 3Alg/HA scaffolds capable of supporting both endochondral and intramembranous bone formation.
33038401	9	66	theme	local	1294:1298	arg1	healing					1305:1311	local bone healing	1294:1311	local bone healing	1294:1311	The studied scaffolds provide a promising therapeutic option to enhance local bone healing because they do not damage liver or kidney functions and do not induce carcinogenic or inflammatory effects.
33038401	0	67	theme	derived	40:46	arg1	composite					76:84	naturally derived alginate/hydroxyapatite bio composite	30:84	naturally derived alginate/hydroxyapatite bio composite	30:84	In vitro and in vivo study of naturally derived alginate/hydroxyapatite bio composite scaffolds.
33038401	2	68	theme	greater	271:277	arg1	biocompatibility					279:294	greater biocompatibility	271:294	greater biocompatibility	271:294	Compared with scaffolds of chemical origin, biogenic scaffolds exhibit greater biocompatibility and enhanced bioactive features.
33038401	4	69	used	used	557:560	arg2	Alginate					544:551	Alginate	544:551	Alginate	544:551	Alginate was used to enhance the mechanical properties as well as the bioactivity and biodegradability of the HA scaffolds.
33038401	4	70	theme	scaffolds	657:665	arg1	biodegradability					630:645	biodegradability	630:645	biodegradability	630:645	Alginate was used to enhance the mechanical properties as well as the bioactivity and biodegradability of the HA scaffolds.
33038401	4	70	theme	scaffolds	657:665	arg1	bioactivity					614:624	bioactivity	614:624	bioactivity	614:624	Alginate was used to enhance the mechanical properties as well as the bioactivity and biodegradability of the HA scaffolds.
33038401	4	70	theme	scaffolds	657:665	arg1	properties					588:597	the mechanical properties	573:597	the mechanical properties as well as the bioactivity and biodegradability of the HA scaffolds	573:665	Alginate was used to enhance the mechanical properties as well as the bioactivity and biodegradability of the HA scaffolds.
34972882	4	0	theme	immunogenic	543:553	arg1	properties					555:564	immunogenic properties	543:564	immunogenic properties	543:564	Among this variety of compounds, several molecules with immunogenic properties were characterized.
34972882	5	1	theme	innate	634:639	arg1	cells					648:652	innate immune cells	634:652	innate immune cells	634:652	It corroborates with their ability to stimulate innate immune cells, induce antibody production and protect insects and mice against fungal infections.
34972882	3	2	contain	carry	384:388	arg2	lipids					390:395	lipids	390:395	lipids	390:395	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	3	2	contain	carry	384:388	arg2	diversity					455:463	a diversity	453:463	a diversity of small metabolites	453:484	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	3	2	contain	carry	384:388	arg2	glycans					425:431	glycans	425:431	glycans	425:431	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	3	2	contain	carry	384:388	arg2	acids					442:446	nucleic acids	434:446	nucleic acids	434:446	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	3	2	contain	carry	384:388	arg1	EVs					380:382	fungal EVs	373:382	fungal EVs	373:382	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	3	2	contain	carry	384:388	arg2	proteins					398:405	proteins	398:405	proteins	398:405	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	3	2	contain	carry	384:388	arg2	polysaccharides					408:422	polysaccharides	408:422	polysaccharides	408:422	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	3	3	theme	small	468:472	arg1	metabolites					474:484	small metabolites	468:484	small metabolites	468:484	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	3	4	theme	Compositional	327:339	arg1	analyses					341:348	Compositional analyses	327:348	Compositional analyses	327:348	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	5	5	theme	immune	641:646	arg1	cells					648:652	innate immune cells	634:652	innate immune cells	634:652	It corroborates with their ability to stimulate innate immune cells, induce antibody production and protect insects and mice against fungal infections.
34972882	3	6	theme	fungal	373:378	arg1	EVs					380:382	fungal EVs	373:382	fungal EVs	373:382	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	4	7	with	molecules	528:536	arg1	properties					555:564	immunogenic properties	543:564	immunogenic properties	543:564	Among this variety of compounds, several molecules with immunogenic properties were characterized.
34972882	5	8	theme	fungal	719:724	arg1	infections					726:735	fungal infections	719:735	fungal infections	719:735	It corroborates with their ability to stimulate innate immune cells, induce antibody production and protect insects and mice against fungal infections.
34972882	6	9	theme	vaccines	853:860	arg1	development					827:837	the development	823:837	the development of antifungal vaccines	823:860	In this chapter, we discuss the advantages of using fungal EVs as a new platform for the development of antifungal vaccines.
34972882	6	10	theme	antifungal	842:851	arg1	vaccines					853:860	antifungal vaccines	842:860	antifungal vaccines	842:860	In this chapter, we discuss the advantages of using fungal EVs as a new platform for the development of antifungal vaccines.
34972882	1	11	theme	Extracellular	79:91	arg1	EVs					103:105	EVs	103:105	EVs	103:105	Extracellular vesicles (EVs) are released by virtually all live cells.
34972882	1	11	theme	Extracellular	79:91	arg1	vesicles					93:100	Extracellular vesicles	79:100	Extracellular vesicles (EVs)	79:106	Extracellular vesicles (EVs) are released by virtually all live cells.
34972882	0	12	theme	Extracellular	7:19	arg1	Vesicles					21:28	Fungal Extracellular Vesicles	0:28	Fungal Extracellular Vesicles	0:28	Fungal Extracellular Vesicles as a Potential Strategy for Vaccine Development.
34972882	0	13	theme	Fungal	0:5	arg1	Vesicles					21:28	Fungal Extracellular Vesicles	0:28	Fungal Extracellular Vesicles	0:28	Fungal Extracellular Vesicles as a Potential Strategy for Vaccine Development.
34972882	4	14	theme	compounds	509:517	arg1	variety					498:504	this variety	493:504	this variety of compounds	493:517	Among this variety of compounds, several molecules with immunogenic properties were characterized.
34972882	4	14	theme	compounds	509:517	arg1	compounds					509:517	compounds	509:517	compounds	509:517	Among this variety of compounds, several molecules with immunogenic properties were characterized.
34972882	2	15	theme	host	272:275	arg1	cells					277:281	host cells	272:281	host cells	272:281	In fungal organisms, the EVs traverse the cell wall and reach the extracellular environment, where they can interact with host cells and potentially impact the disease outcome.
34972882	6	16	theme	fungal	790:795	arg1	EVs					797:799	fungal EVs	790:799	fungal EVs	790:799	In this chapter, we discuss the advantages of using fungal EVs as a new platform for the development of antifungal vaccines.
34972882	6	16	theme	fungal	790:795	arg1	platform					810:817	a new platform	804:817	a new platform for the development of antifungal vaccines	804:860	In this chapter, we discuss the advantages of using fungal EVs as a new platform for the development of antifungal vaccines.
34972882	3	17	theme	nucleic	434:440	arg1	acids					442:446	nucleic acids	434:446	nucleic acids	434:446	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	1	18	theme	all	134:136	arg1	cells					143:147	virtually all live cells	124:147	virtually all live cells	124:147	Extracellular vesicles (EVs) are released by virtually all live cells.
34972882	0	19	theme	Potential	35:43	arg1	Strategy					45:52	a Potential Strategy	33:52	a Potential Strategy for Vaccine Development	33:76	Fungal Extracellular Vesicles as a Potential Strategy for Vaccine Development.
34972882	4	20	theme	several	520:526	arg1	molecules					528:536	several molecules	520:536	several molecules with immunogenic properties	520:564	Among this variety of compounds, several molecules with immunogenic properties were characterized.
34972882	2	21	theme	fungal	153:158	arg1	organisms					160:168	fungal organisms	153:168	fungal organisms	153:168	In fungal organisms, the EVs traverse the cell wall and reach the extracellular environment, where they can interact with host cells and potentially impact the disease outcome.
34972882	2	22	theme	disease	310:316	arg1	outcome					318:324	the disease outcome	306:324	the disease outcome	306:324	In fungal organisms, the EVs traverse the cell wall and reach the extracellular environment, where they can interact with host cells and potentially impact the disease outcome.
34972882	6	23	theme	new	806:808	arg1	EVs					797:799	fungal EVs	790:799	fungal EVs	790:799	In this chapter, we discuss the advantages of using fungal EVs as a new platform for the development of antifungal vaccines.
34972882	6	23	theme	new	806:808	arg1	platform					810:817	a new platform	804:817	a new platform for the development of antifungal vaccines	804:860	In this chapter, we discuss the advantages of using fungal EVs as a new platform for the development of antifungal vaccines.
34972882	2	24	theme	cell	192:195	arg1	wall					197:200	the cell wall	188:200	the cell wall	188:200	In fungal organisms, the EVs traverse the cell wall and reach the extracellular environment, where they can interact with host cells and potentially impact the disease outcome.
34972882	5	25	theme	antibody	662:669	arg1	production					671:680	antibody production	662:680	antibody production	662:680	It corroborates with their ability to stimulate innate immune cells, induce antibody production and protect insects and mice against fungal infections.
34972882	2	26	theme	extracellular	216:228	arg1	environment					230:240	the extracellular environment	212:240	the extracellular environment	212:240	In fungal organisms, the EVs traverse the cell wall and reach the extracellular environment, where they can interact with host cells and potentially impact the disease outcome.
34972882	3	27	theme	metabolites	474:484	arg1	proteins					398:405	proteins	398:405	proteins	398:405	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	3	27	theme	metabolites	474:484	arg1	polysaccharides					408:422	polysaccharides	408:422	polysaccharides	408:422	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	3	27	theme	metabolites	474:484	arg1	diversity					455:463	a diversity	453:463	a diversity of small metabolites	453:484	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	3	27	theme	metabolites	474:484	arg1	lipids					390:395	lipids	390:395	lipids	390:395	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	3	27	theme	metabolites	474:484	arg1	glycans					425:431	glycans	425:431	glycans	425:431	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	3	27	theme	metabolites	474:484	arg1	acids					442:446	nucleic acids	434:446	nucleic acids	434:446	Compositional analyses have demonstrated that fungal EVs carry lipids, proteins, polysaccharides, glycans, nucleic acids, and a diversity of small metabolites.
34972882	0	28	theme	Vaccine	58:64	arg1	Development					66:76	Vaccine Development	58:76	Vaccine Development	58:76	Fungal Extracellular Vesicles as a Potential Strategy for Vaccine Development.
34972882	1	29	theme	live	138:141	arg1	cells					143:147	virtually all live cells	124:147	virtually all live cells	124:147	Extracellular vesicles (EVs) are released by virtually all live cells.
32645491	2	0	theme	styrene-co-maleic	452:468	arg1	anhydride					470:478	styrene-co-maleic anhydride	452:478	styrene-co-maleic anhydride	452:478	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	2	0	theme	styrene-co-maleic	452:468	arg1	poly-					446:450	poly-	446:450	poly-(styrene-co-maleic anhydride) (PSMA)	446:486	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	1	1	theme	drug	313:316	arg1	release					300:306	the burst release	290:306	the burst release of a drug	290:316	The work investigated the possibility to develop an easy scalable treatment capable of modifying only the surface of chitosan-based materials, limiting the degradation of the bulk and the burst release of a drug, without compromising the properties of the polymeric matrix.
32645491	1	1	theme	drug	313:316	arg1	degradation					262:272	the degradation	258:272	the degradation of the bulk	258:284	The work investigated the possibility to develop an easy scalable treatment capable of modifying only the surface of chitosan-based materials, limiting the degradation of the bulk and the burst release of a drug, without compromising the properties of the polymeric matrix.
32645491	2	2	theme	maleic	563:568	arg1	functionalities					570:584	maleic functionalities	563:584	maleic functionalities of PSMA	563:592	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	6	3	theme	Bovine	1227:1232	arg1	Albumin					1240:1246	Bovine Serum Albumin	1227:1246	the protein Bovine Serum Albumin (BSA)	1215:1252	The release properties of the treated and of the untreated particles, over a period of 10 h, were tested using, as model drug, the protein Bovine Serum Albumin (BSA).
32645491	6	3	theme	Bovine	1227:1232	arg1	BSA					1249:1251	BSA	1249:1251	BSA	1249:1251	The release properties of the treated and of the untreated particles, over a period of 10 h, were tested using, as model drug, the protein Bovine Serum Albumin (BSA).
32645491	0	4	theme	drug	59:62	arg1	release					64:70	the drug release	55:70	the drug release of chitosan-based microparticles	55:103	On an effective approach to improve the properties and the drug release of chitosan-based microparticles.
32645491	4	5	theme	wettability	858:868	arg1	change					848:853	the change	844:853	the change of wettability in the modified systems	844:892	Contact angle measurements demonstrated the change of wettability in the modified systems and TGA analysis allowed to estimate the amount of the deposited PSMA.
32645491	0	6	theme	chitosan-based	75:88	arg1	microparticles					90:103	chitosan-based microparticles	75:103	chitosan-based microparticles	75:103	On an effective approach to improve the properties and the drug release of chitosan-based microparticles.
32645491	2	7	theme	groups	552:557	arg1	reactivity					523:532	the potential reactivity	509:532	the potential reactivity of chitosan amino groups and maleic functionalities of PSMA	509:592	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	7	8	theme	cancer	1363:1368	arg1	cells					1370:1374	MCF-7 human breast cancer cells	1344:1374	MCF-7 human breast cancer cells	1344:1374	Finally, the cytocompatibility of the developed composite microparticles was assessed on MCF-7 human breast cancer cells, which measurements demonstrated the non-toxicity of the treatment.
32645491	4	9	from	change	848:853	arg1	systems					886:892	the modified systems	873:892	the modified systems	873:892	Contact angle measurements demonstrated the change of wettability in the modified systems and TGA analysis allowed to estimate the amount of the deposited PSMA.
32645491	2	10	theme	amino	546:550	arg1	PSMA					589:592	PSMA	589:592	PSMA	589:592	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	2	10	theme	amino	546:550	arg1	groups					552:557	chitosan amino groups	537:557	chitosan amino groups	537:557	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	6	11	theme	particles	1147:1155	arg1	properties					1100:1109	The release properties	1088:1109	The release properties of the treated and of the untreated particles	1088:1155	The release properties of the treated and of the untreated particles, over a period of 10 h, were tested using, as model drug, the protein Bovine Serum Albumin (BSA).
32645491	6	12	dep	protein	1219:1225	arg1	Albumin					1240:1246	Bovine Serum Albumin	1227:1246	the protein Bovine Serum Albumin (BSA)	1215:1252	The release properties of the treated and of the untreated particles, over a period of 10 h, were tested using, as model drug, the protein Bovine Serum Albumin (BSA).
32645491	6	12	dep	protein	1219:1225	arg1	BSA					1249:1251	BSA	1249:1251	BSA	1249:1251	The release properties of the treated and of the untreated particles, over a period of 10 h, were tested using, as model drug, the protein Bovine Serum Albumin (BSA).
32645491	3	13	theme	FE-SEM	705:710	arg1	analysis					712:719	FE-SEM analysis	705:719	FE-SEM analysis	705:719	The specific reactions/interactions occurring between the two polymers were studied by IR measurements, while FE-SEM analysis evidenced the modification of the morphology of the particles contacted with PSMA.
32645491	6	14	theme	model	1203:1207	arg1	drug					1209:1212	model drug	1203:1212	model drug	1203:1212	The release properties of the treated and of the untreated particles, over a period of 10 h, were tested using, as model drug, the protein Bovine Serum Albumin (BSA).
32645491	6	15	theme	untreated	1137:1145	arg1	particles					1147:1155	the untreated particles	1133:1155	the untreated particles	1133:1155	The release properties of the treated and of the untreated particles, over a period of 10 h, were tested using, as model drug, the protein Bovine Serum Albumin (BSA).
32645491	1	16	theme	easy	158:161	arg1	treatment					172:180	an easy scalable treatment	155:180	an easy scalable treatment capable of modifying only the surface of chitosan-based materials	155:246	The work investigated the possibility to develop an easy scalable treatment capable of modifying only the surface of chitosan-based materials, limiting the degradation of the bulk and the burst release of a drug, without compromising the properties of the polymeric matrix.
32645491	0	17	theme	microparticles	90:103	arg1	approach					16:23	an effective approach	3:23	an effective approach to improve the properties	3:49	On an effective approach to improve the properties and the drug release of chitosan-based microparticles.
32645491	0	17	theme	microparticles	90:103	arg1	release					64:70	the drug release	55:70	the drug release of chitosan-based microparticles	55:103	On an effective approach to improve the properties and the drug release of chitosan-based microparticles.
32645491	2	18	theme	PSMA	589:592	arg1	PSMA					589:592	PSMA	589:592	PSMA	589:592	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	2	18	theme	PSMA	589:592	arg1	groups					552:557	chitosan amino groups	537:557	chitosan amino groups	537:557	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	2	18	theme	PSMA	589:592	arg1	functionalities					570:584	maleic functionalities	563:584	maleic functionalities of PSMA	563:592	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	7	19	theme	breast	1356:1361	arg1	cells					1370:1374	MCF-7 human breast cancer cells	1344:1374	MCF-7 human breast cancer cells	1344:1374	Finally, the cytocompatibility of the developed composite microparticles was assessed on MCF-7 human breast cancer cells, which measurements demonstrated the non-toxicity of the treatment.
32645491	1	20	theme	scalable	163:170	arg1	treatment					172:180	an easy scalable treatment	155:180	an easy scalable treatment capable of modifying only the surface of chitosan-based materials	155:246	The work investigated the possibility to develop an easy scalable treatment capable of modifying only the surface of chitosan-based materials, limiting the degradation of the bulk and the burst release of a drug, without compromising the properties of the polymeric matrix.
32645491	5	21	theme	enzymatic	1070:1078	arg1	system					1080:1085	an enzymatic system	1067:1085	an enzymatic system	1067:1085	The above treatment turned out to improve the particle stability both in an acidic environment and in an enzymatic system.
32645491	2	22	theme	CHI	411:413	arg1	microparticles					393:406	microparticles	393:406	microparticles of CHI	393:413	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	2	23	theme	functionalities	570:584	arg1	reactivity					523:532	the potential reactivity	509:532	the potential reactivity of chitosan amino groups and maleic functionalities of PSMA	509:592	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	7	24	theme	MCF-7	1344:1348	arg1	cells					1370:1374	MCF-7 human breast cancer cells	1344:1374	MCF-7 human breast cancer cells	1344:1374	Finally, the cytocompatibility of the developed composite microparticles was assessed on MCF-7 human breast cancer cells, which measurements demonstrated the non-toxicity of the treatment.
32645491	1	25	theme	capable	182:188	arg1	treatment					172:180	an easy scalable treatment	155:180	an easy scalable treatment capable of modifying only the surface of chitosan-based materials	155:246	The work investigated the possibility to develop an easy scalable treatment capable of modifying only the surface of chitosan-based materials, limiting the degradation of the bulk and the burst release of a drug, without compromising the properties of the polymeric matrix.
32645491	6	26	theme	Serum	1234:1238	arg1	Albumin					1240:1246	Bovine Serum Albumin	1227:1246	the protein Bovine Serum Albumin (BSA)	1215:1252	The release properties of the treated and of the untreated particles, over a period of 10 h, were tested using, as model drug, the protein Bovine Serum Albumin (BSA).
32645491	6	26	theme	Serum	1234:1238	arg1	BSA					1249:1251	BSA	1249:1251	BSA	1249:1251	The release properties of the treated and of the untreated particles, over a period of 10 h, were tested using, as model drug, the protein Bovine Serum Albumin (BSA).
32645491	5	27	theme	particle	1011:1018	arg1	stability					1020:1028	the particle stability	1007:1028	the particle stability	1007:1028	The above treatment turned out to improve the particle stability both in an acidic environment and in an enzymatic system.
32645491	6	28	theme	treated	1118:1124	arg1	properties					1100:1109	The release properties	1088:1109	The release properties of the treated and of the untreated particles	1088:1155	The release properties of the treated and of the untreated particles, over a period of 10 h, were tested using, as model drug, the protein Bovine Serum Albumin (BSA).
32645491	0	29	theme	effective	6:14	arg1	approach					16:23	an effective approach	3:23	an effective approach to improve the properties	3:49	On an effective approach to improve the properties and the drug release of chitosan-based microparticles.
32645491	1	30	theme	bulk	281:284	arg1	release					300:306	the burst release	290:306	the burst release of a drug	290:316	The work investigated the possibility to develop an easy scalable treatment capable of modifying only the surface of chitosan-based materials, limiting the degradation of the bulk and the burst release of a drug, without compromising the properties of the polymeric matrix.
32645491	1	30	theme	bulk	281:284	arg1	degradation					262:272	the degradation	258:272	the degradation of the bulk	258:284	The work investigated the possibility to develop an easy scalable treatment capable of modifying only the surface of chitosan-based materials, limiting the degradation of the bulk and the burst release of a drug, without compromising the properties of the polymeric matrix.
32645491	7	31	theme	human	1350:1354	arg1	cells					1370:1374	MCF-7 human breast cancer cells	1344:1374	MCF-7 human breast cancer cells	1344:1374	Finally, the cytocompatibility of the developed composite microparticles was assessed on MCF-7 human breast cancer cells, which measurements demonstrated the non-toxicity of the treatment.
32645491	5	32	theme	acidic	1041:1046	arg1	environment					1048:1058	an acidic environment	1038:1058	an acidic environment	1038:1058	The above treatment turned out to improve the particle stability both in an acidic environment and in an enzymatic system.
32645491	1	33	theme	polymeric	362:370	arg1	matrix					372:377	the polymeric matrix	358:377	the polymeric matrix	358:377	The work investigated the possibility to develop an easy scalable treatment capable of modifying only the surface of chitosan-based materials, limiting the degradation of the bulk and the burst release of a drug, without compromising the properties of the polymeric matrix.
32645491	7	34	theme	composite	1303:1311	arg1	microparticles					1313:1326	the developed composite microparticles	1289:1326	the developed composite microparticles	1289:1326	Finally, the cytocompatibility of the developed composite microparticles was assessed on MCF-7 human breast cancer cells, which measurements demonstrated the non-toxicity of the treatment.
32645491	3	35	theme	morphology	755:764	arg1	modification					735:746	the modification	731:746	the modification of the morphology of the particles contacted with PSMA	731:801	The specific reactions/interactions occurring between the two polymers were studied by IR measurements, while FE-SEM analysis evidenced the modification of the morphology of the particles contacted with PSMA.
32645491	1	36	theme	matrix	372:377	arg1	properties					344:353	the properties	340:353	the properties of the polymeric matrix	340:377	The work investigated the possibility to develop an easy scalable treatment capable of modifying only the surface of chitosan-based materials, limiting the degradation of the bulk and the burst release of a drug, without compromising the properties of the polymeric matrix.
32645491	7	37	theme	microparticles	1313:1326	arg1	cytocompatibility					1268:1284	the cytocompatibility	1264:1284	the cytocompatibility of the developed composite microparticles	1264:1326	Finally, the cytocompatibility of the developed composite microparticles was assessed on MCF-7 human breast cancer cells, which measurements demonstrated the non-toxicity of the treatment.
32645491	7	38	theme	developed	1293:1301	arg1	microparticles					1313:1326	the developed composite microparticles	1289:1326	the developed composite microparticles	1289:1326	Finally, the cytocompatibility of the developed composite microparticles was assessed on MCF-7 human breast cancer cells, which measurements demonstrated the non-toxicity of the treatment.
32645491	1	39	theme	burst	294:298	arg1	release					300:306	the burst release	290:306	the burst release of a drug	290:316	The work investigated the possibility to develop an easy scalable treatment capable of modifying only the surface of chitosan-based materials, limiting the degradation of the bulk and the burst release of a drug, without compromising the properties of the polymeric matrix.
32645491	2	40	theme	chitosan	537:544	arg1	PSMA					589:592	PSMA	589:592	PSMA	589:592	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	2	40	theme	chitosan	537:544	arg1	groups					552:557	chitosan amino groups	537:557	chitosan amino groups	537:557	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	3	41	theme	specific	599:606	arg1	reactions/interactions					608:629	The specific reactions/interactions	595:629	The specific reactions/interactions occurring between the two polymers	595:664	The specific reactions/interactions occurring between the two polymers were studied by IR measurements, while FE-SEM analysis evidenced the modification of the morphology of the particles contacted with PSMA.
32645491	4	42	theme	angle	812:816	arg1	measurements					818:829	Contact angle measurements	804:829	Contact angle measurements	804:829	Contact angle measurements demonstrated the change of wettability in the modified systems and TGA analysis allowed to estimate the amount of the deposited PSMA.
32645491	4	43	theme	TGA	898:900	arg1	analysis					902:909	TGA analysis	898:909	TGA analysis	898:909	Contact angle measurements demonstrated the change of wettability in the modified systems and TGA analysis allowed to estimate the amount of the deposited PSMA.
32645491	4	44	theme	modified	877:884	arg1	systems					886:892	the modified systems	873:892	the modified systems	873:892	Contact angle measurements demonstrated the change of wettability in the modified systems and TGA analysis allowed to estimate the amount of the deposited PSMA.
32645491	4	45	theme	Contact	804:810	arg1	measurements					818:829	Contact angle measurements	804:829	Contact angle measurements	804:829	Contact angle measurements demonstrated the change of wettability in the modified systems and TGA analysis allowed to estimate the amount of the deposited PSMA.
32645491	6	46	theme	10 h	1175:1178	arg1	period					1165:1170	a period	1163:1170	a period of 10 h	1163:1178	The release properties of the treated and of the untreated particles, over a period of 10 h, were tested using, as model drug, the protein Bovine Serum Albumin (BSA).
32645491	2	47	theme	reactivity	523:532	arg1	advantage					496:504	advantage	496:504	advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA	496:592	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	5	48	theme	above	969:973	arg1	treatment					975:983	The above treatment	965:983	The above treatment	965:983	The above treatment turned out to improve the particle stability both in an acidic environment and in an enzymatic system.
32645491	6	49	theme	release	1092:1098	arg1	properties					1100:1109	The release properties	1088:1109	The release properties of the treated and of the untreated particles	1088:1155	The release properties of the treated and of the untreated particles, over a period of 10 h, were tested using, as model drug, the protein Bovine Serum Albumin (BSA).
32645491	2	50	theme	potential	513:521	arg1	reactivity					523:532	the potential reactivity	509:532	the potential reactivity of chitosan amino groups and maleic functionalities of PSMA	509:592	To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA.
32645491	7	51	theme	treatment	1433:1441	arg1	non-toxicity					1413:1424	the non-toxicity	1409:1424	the non-toxicity of the treatment	1409:1441	Finally, the cytocompatibility of the developed composite microparticles was assessed on MCF-7 human breast cancer cells, which measurements demonstrated the non-toxicity of the treatment.
32645491	4	52	theme	PSMA	959:962	arg1	PSMA					959:962	the deposited PSMA	945:962	the deposited PSMA	945:962	Contact angle measurements demonstrated the change of wettability in the modified systems and TGA analysis allowed to estimate the amount of the deposited PSMA.
32645491	4	52	theme	PSMA	959:962	arg1	amount					935:940	the amount	931:940	the amount of the deposited PSMA	931:962	Contact angle measurements demonstrated the change of wettability in the modified systems and TGA analysis allowed to estimate the amount of the deposited PSMA.
32645491	1	53	theme	chitosan-based	223:236	arg1	materials					238:246	chitosan-based materials	223:246	chitosan-based materials	223:246	The work investigated the possibility to develop an easy scalable treatment capable of modifying only the surface of chitosan-based materials, limiting the degradation of the bulk and the burst release of a drug, without compromising the properties of the polymeric matrix.
32645491	4	54	theme	deposited	949:957	arg1	PSMA					959:962	the deposited PSMA	945:962	the deposited PSMA	945:962	Contact angle measurements demonstrated the change of wettability in the modified systems and TGA analysis allowed to estimate the amount of the deposited PSMA.
32645491	3	55	theme	particles	773:781	arg1	morphology					755:764	the morphology	751:764	the morphology of the particles contacted with PSMA	751:801	The specific reactions/interactions occurring between the two polymers were studied by IR measurements, while FE-SEM analysis evidenced the modification of the morphology of the particles contacted with PSMA.
32645491	3	56	theme	IR	682:683	arg1	measurements					685:696	IR measurements	682:696	IR measurements	682:696	The specific reactions/interactions occurring between the two polymers were studied by IR measurements, while FE-SEM analysis evidenced the modification of the morphology of the particles contacted with PSMA.
32645491	1	57	theme	materials	238:246	arg1	surface					212:218	only the surface	203:218	only the surface of chitosan-based materials	203:246	The work investigated the possibility to develop an easy scalable treatment capable of modifying only the surface of chitosan-based materials, limiting the degradation of the bulk and the burst release of a drug, without compromising the properties of the polymeric matrix.
34797663	0	0	theme	Acid-Sodium	94:104	arg1	Complexes					115:123	Ursolic Acid-Sodium Alginate Complexes	86:123	Ursolic Acid-Sodium Alginate Complexes	86:123	Development, Physical-Chemical Characterization, and Molecular Docking Simulations of Ursolic Acid-Sodium Alginate Complexes.
34797663	5	1	with	bonding	902:908	arg1	group					928:932	the carbonyl group	915:932	the carbonyl group	915:932	By Fourier transform infrared spectroscopy (FTIR) and molecular docking simulations, it was observed that the hydroxyl group in UA formed hydrogen bonding with the carbonyl group in SA.
34797663	4	2	theme	electron	625:632	arg1	SEM					646:648	SEM	646:648	SEM	646:648	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	4	2	theme	electron	625:632	arg1	microscopy					634:643	scanning electron microscopy	616:643	scanning electron microscopy (SEM)	616:649	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	0	3	theme	Ursolic	86:92	arg1	Complexes					115:123	Ursolic Acid-Sodium Alginate Complexes	86:123	Ursolic Acid-Sodium Alginate Complexes	86:123	Development, Physical-Chemical Characterization, and Molecular Docking Simulations of Ursolic Acid-Sodium Alginate Complexes.
34797663	2	4	theme	1,1-diphenyl-2-trinitrophenylhydrazine	325:362	arg1	assay					365:369	the DPPH (1,1-diphenyl-2-trinitrophenylhydrazine) assay	315:369	the DPPH (1,1-diphenyl-2-trinitrophenylhydrazine) assay	315:369	The antioxidant activity was evaluated by the DPPH (1,1-diphenyl-2-trinitrophenylhydrazine) assay and the pyrogallol auto-oxidation method.
34797663	1	5	theme	dissolution	229:239	arg1	rate					241:244	the dissolution rate	225:244	the dissolution rate	225:244	The aim of this study was to fabricate ursolic acid (UA)-sodium alginate (SA) complexes to improve the dissolution rate and antioxidant abilities.
34797663	0	6	theme	Complexes	115:123	arg1	Development					0:10	Development	0:10	Development	0:10	Development, Physical-Chemical Characterization, and Molecular Docking Simulations of Ursolic Acid-Sodium Alginate Complexes.
34797663	0	6	theme	Complexes	115:123	arg1	Characterization					31:46	Physical-Chemical Characterization	13:46	Physical-Chemical Characterization	13:46	Development, Physical-Chemical Characterization, and Molecular Docking Simulations of Ursolic Acid-Sodium Alginate Complexes.
34797663	0	6	theme	Complexes	115:123	arg1	Simulations					71:81	Molecular Docking Simulations	53:81	Molecular Docking Simulations	53:81	Development, Physical-Chemical Characterization, and Molecular Docking Simulations of Ursolic Acid-Sodium Alginate Complexes.
34797663	7	7	theme	functional	1111:1120	arg1	ingredients					1127:1137	lipophilic functional food ingredients	1100:1137	lipophilic functional food ingredients due to improved solubility and antioxidant activity	1100:1189	The results indicated that SA could serve as a promising carrier for lipophilic functional food ingredients due to improved solubility and antioxidant activity.
34797663	1	8	theme	ursolic	165:171	arg1	UA					179:180	UA	179:180	UA	179:180	The aim of this study was to fabricate ursolic acid (UA)-sodium alginate (SA) complexes to improve the dissolution rate and antioxidant abilities.
34797663	1	8	theme	ursolic	165:171	arg1	acid					173:176	ursolic acid	165:176	ursolic acid (UA)-sodium alginate (SA) complexes	165:212	The aim of this study was to fabricate ursolic acid (UA)-sodium alginate (SA) complexes to improve the dissolution rate and antioxidant abilities.
34797663	0	9	theme	Alginate	106:113	arg1	Complexes					115:123	Ursolic Acid-Sodium Alginate Complexes	86:123	Ursolic Acid-Sodium Alginate Complexes	86:123	Development, Physical-Chemical Characterization, and Molecular Docking Simulations of Ursolic Acid-Sodium Alginate Complexes.
34797663	7	10	theme	improved	1146:1153	arg1	solubility					1155:1164	improved solubility	1146:1164	improved solubility	1146:1164	The results indicated that SA could serve as a promising carrier for lipophilic functional food ingredients due to improved solubility and antioxidant activity.
34797663	5	11	theme	docking	819:825	arg1	simulations					827:837	molecular docking simulations	809:837	molecular docking simulations	809:837	By Fourier transform infrared spectroscopy (FTIR) and molecular docking simulations, it was observed that the hydroxyl group in UA formed hydrogen bonding with the carbonyl group in SA.
34797663	6	12	theme	free	1022:1025	arg1	UA					1027:1028	free UA	1022:1028	free UA	1022:1028	The DPPH scavenger activities of the complexes were also increased compared with free UA.
34797663	4	13	theme	scanning	616:623	arg1	SEM					646:648	SEM	646:648	SEM	646:648	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	4	13	theme	scanning	616:623	arg1	microscopy					634:643	scanning electron microscopy	616:643	scanning electron microscopy (SEM)	616:649	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	6	14	theme	scavenger	950:958	arg1	activities					960:969	The DPPH scavenger activities	941:969	The DPPH scavenger activities of the complexes	941:986	The DPPH scavenger activities of the complexes were also increased compared with free UA.
34797663	3	15	theme	UA	494:495	arg1	%					520:520	about 101.22 ± 1.50%	501:520	about 101.22 ± 1.50% for 180 min	501:532	For the optimal composition ratio of UA:SA (1:5, w/w), the cumulative release of UA was about 101.22 ± 1.50% for 180 min.
34797663	3	15	theme	UA	494:495	arg1	release					483:489	the cumulative release	468:489	the cumulative release of UA	468:495	For the optimal composition ratio of UA:SA (1:5, w/w), the cumulative release of UA was about 101.22 ± 1.50% for 180 min.
34797663	3	16	theme	composition	429:439	arg1	ratio					441:445	the optimal composition ratio	417:445	the optimal composition ratio of UA:SA (1:5, w/w)	417:465	For the optimal composition ratio of UA:SA (1:5, w/w), the cumulative release of UA was about 101.22 ± 1.50% for 180 min.
34797663	1	17	theme	acid	173:176	arg1	complexes					204:212	ursolic acid (UA)-sodium alginate (SA) complexes	165:212	ursolic acid (UA)-sodium alginate (SA) complexes	165:212	The aim of this study was to fabricate ursolic acid (UA)-sodium alginate (SA) complexes to improve the dissolution rate and antioxidant abilities.
34797663	4	18	theme	UA	696:697	arg1	crystallinity					679:691	the crystallinity	675:691	the crystallinity of UA	675:697	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	5	19	from	bonding	902:908	arg1	SA					937:938	SA	937:938	SA	937:938	By Fourier transform infrared spectroscopy (FTIR) and molecular docking simulations, it was observed that the hydroxyl group in UA formed hydrogen bonding with the carbonyl group in SA.
34797663	2	20	theme	auto-oxidation	390:403	arg1	method					405:410	the pyrogallol auto-oxidation method	375:410	the pyrogallol auto-oxidation method	375:410	The antioxidant activity was evaluated by the DPPH (1,1-diphenyl-2-trinitrophenylhydrazine) assay and the pyrogallol auto-oxidation method.
34797663	5	21	from	group	874:878	arg1	UA					883:884	UA	883:884	UA	883:884	By Fourier transform infrared spectroscopy (FTIR) and molecular docking simulations, it was observed that the hydroxyl group in UA formed hydrogen bonding with the carbonyl group in SA.
34797663	7	22	theme	food	1122:1125	arg1	ingredients					1127:1137	lipophilic functional food ingredients	1100:1137	lipophilic functional food ingredients due to improved solubility and antioxidant activity	1100:1189	The results indicated that SA could serve as a promising carrier for lipophilic functional food ingredients due to improved solubility and antioxidant activity.
34797663	4	23	theme	calorimetry	593:603	arg1	analyses					651:658	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses	535:658	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses	535:658	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	2	24	theme	pyrogallol	379:388	arg1	method					405:410	the pyrogallol auto-oxidation method	375:410	the pyrogallol auto-oxidation method	375:410	The antioxidant activity was evaluated by the DPPH (1,1-diphenyl-2-trinitrophenylhydrazine) assay and the pyrogallol auto-oxidation method.
34797663	1	25	theme	antioxidant	250:260	arg1	abilities					262:270	antioxidant abilities	250:270	antioxidant abilities	250:270	The aim of this study was to fabricate ursolic acid (UA)-sodium alginate (SA) complexes to improve the dissolution rate and antioxidant abilities.
34797663	6	26	theme	complexes	978:986	arg1	activities					960:969	The DPPH scavenger activities	941:969	The DPPH scavenger activities of the complexes	941:986	The DPPH scavenger activities of the complexes were also increased compared with free UA.
34797663	3	27	theme	±	514:514	arg1	release					483:489	the cumulative release	468:489	the cumulative release of UA	468:495	For the optimal composition ratio of UA:SA (1:5, w/w), the cumulative release of UA was about 101.22 ± 1.50% for 180 min.
34797663	3	27	theme	±	514:514	arg1	%					520:520	about 101.22 ± 1.50%	501:520	about 101.22 ± 1.50% for 180 min	501:532	For the optimal composition ratio of UA:SA (1:5, w/w), the cumulative release of UA was about 101.22 ± 1.50% for 180 min.
34797663	1	28	theme	-sodium	182:188	arg1	complexes					204:212	ursolic acid (UA)-sodium alginate (SA) complexes	165:212	ursolic acid (UA)-sodium alginate (SA) complexes	165:212	The aim of this study was to fabricate ursolic acid (UA)-sodium alginate (SA) complexes to improve the dissolution rate and antioxidant abilities.
34797663	0	29	theme	Physical-Chemical	13:29	arg1	Characterization					31:46	Physical-Chemical Characterization	13:46	Physical-Chemical Characterization	13:46	Development, Physical-Chemical Characterization, and Molecular Docking Simulations of Ursolic Acid-Sodium Alginate Complexes.
34797663	2	30	theme	antioxidant	277:287	arg1	activity					289:296	The antioxidant activity	273:296	The antioxidant activity	273:296	The antioxidant activity was evaluated by the DPPH (1,1-diphenyl-2-trinitrophenylhydrazine) assay and the pyrogallol auto-oxidation method.
34797663	1	31	theme	alginate	190:197	arg1	complexes					204:212	ursolic acid (UA)-sodium alginate (SA) complexes	165:212	ursolic acid (UA)-sodium alginate (SA) complexes	165:212	The aim of this study was to fabricate ursolic acid (UA)-sodium alginate (SA) complexes to improve the dissolution rate and antioxidant abilities.
34797663	4	32	theme	microscopy	634:643	arg1	analyses					651:658	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses	535:658	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses	535:658	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	6	33	theme	DPPH	945:948	arg1	activities					960:969	The DPPH scavenger activities	941:969	The DPPH scavenger activities of the complexes	941:986	The DPPH scavenger activities of the complexes were also increased compared with free UA.
34797663	4	34	theme	scanning	584:591	arg1	DSC					606:608	DSC	606:608	DSC	606:608	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	4	34	theme	scanning	584:591	arg1	calorimetry					593:603	differential scanning calorimetry	571:603	differential scanning calorimetry (DSC)	571:609	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	3	35	theme	optimal	421:427	arg1	ratio					441:445	the optimal composition ratio	417:445	the optimal composition ratio of UA:SA (1:5, w/w)	417:465	For the optimal composition ratio of UA:SA (1:5, w/w), the cumulative release of UA was about 101.22 ± 1.50% for 180 min.
34797663	3	36	dep	ratio	441:445	arg1	SA					453:454	SA	453:454	the optimal composition ratio of UA:SA (1:5, w/w)	417:465	For the optimal composition ratio of UA:SA (1:5, w/w), the cumulative release of UA was about 101.22 ± 1.50% for 180 min.
34797663	1	37	theme	SA	200:201	arg1	complexes					204:212	ursolic acid (UA)-sodium alginate (SA) complexes	165:212	ursolic acid (UA)-sodium alginate (SA) complexes	165:212	The aim of this study was to fabricate ursolic acid (UA)-sodium alginate (SA) complexes to improve the dissolution rate and antioxidant abilities.
34797663	0	38	theme	Docking	63:69	arg1	Simulations					71:81	Molecular Docking Simulations	53:81	Molecular Docking Simulations	53:81	Development, Physical-Chemical Characterization, and Molecular Docking Simulations of Ursolic Acid-Sodium Alginate Complexes.
34797663	7	39	theme	due	1139:1141	arg1	ingredients					1127:1137	lipophilic functional food ingredients	1100:1137	lipophilic functional food ingredients due to improved solubility and antioxidant activity	1100:1189	The results indicated that SA could serve as a promising carrier for lipophilic functional food ingredients due to improved solubility and antioxidant activity.
34797663	0	40	theme	Molecular	53:61	arg1	Simulations					71:81	Molecular Docking Simulations	53:81	Molecular Docking Simulations	53:81	Development, Physical-Chemical Characterization, and Molecular Docking Simulations of Ursolic Acid-Sodium Alginate Complexes.
34797663	3	41	theme	cumulative	472:481	arg1	%					520:520	about 101.22 ± 1.50%	501:520	about 101.22 ± 1.50% for 180 min	501:532	For the optimal composition ratio of UA:SA (1:5, w/w), the cumulative release of UA was about 101.22 ± 1.50% for 180 min.
34797663	3	41	theme	cumulative	472:481	arg1	release					483:489	the cumulative release	468:489	the cumulative release of UA	468:495	For the optimal composition ratio of UA:SA (1:5, w/w), the cumulative release of UA was about 101.22 ± 1.50% for 180 min.
34797663	2	42	theme	DPPH	319:322	arg1	assay					365:369	the DPPH (1,1-diphenyl-2-trinitrophenylhydrazine) assay	315:369	the DPPH (1,1-diphenyl-2-trinitrophenylhydrazine) assay	315:369	The antioxidant activity was evaluated by the DPPH (1,1-diphenyl-2-trinitrophenylhydrazine) assay and the pyrogallol auto-oxidation method.
34797663	5	43	dep	Fourier	758:764	arg1	transform					766:774	transform	766:774	transform infrared spectroscopy (FTIR) and molecular docking simulations	766:837	By Fourier transform infrared spectroscopy (FTIR) and molecular docking simulations, it was observed that the hydroxyl group in UA formed hydrogen bonding with the carbonyl group in SA.
34797663	5	44	dep	transform	766:774	arg1	infrared					776:783	infrared	776:783	transform infrared spectroscopy (FTIR) and molecular docking simulations	766:837	By Fourier transform infrared spectroscopy (FTIR) and molecular docking simulations, it was observed that the hydroxyl group in UA formed hydrogen bonding with the carbonyl group in SA.
34797663	7	45	theme	antioxidant	1170:1180	arg1	activity					1182:1189	antioxidant activity	1170:1189	antioxidant activity	1170:1189	The results indicated that SA could serve as a promising carrier for lipophilic functional food ingredients due to improved solubility and antioxidant activity.
34797663	5	46	theme	hydroxyl	865:872	arg1	group					874:878	the hydroxyl group	861:878	the hydroxyl group in UA	861:884	By Fourier transform infrared spectroscopy (FTIR) and molecular docking simulations, it was observed that the hydroxyl group in UA formed hydrogen bonding with the carbonyl group in SA.
34797663	4	47	theme	diffractometry	548:561	arg1	analyses					651:658	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses	535:658	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses	535:658	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	5	48	theme	hydrogen	893:900	arg1	bonding					902:908	hydrogen bonding	893:908	hydrogen bonding with the carbonyl group in SA	893:938	By Fourier transform infrared spectroscopy (FTIR) and molecular docking simulations, it was observed that the hydroxyl group in UA formed hydrogen bonding with the carbonyl group in SA.
34797663	3	49	dep	SA	453:454	arg1	w/w					462:464	w/w	462:464	w/w	462:464	For the optimal composition ratio of UA:SA (1:5, w/w), the cumulative release of UA was about 101.22 ± 1.50% for 180 min.
34797663	3	49	dep	SA	453:454	arg1	1:5					457:459	1:5	457:459	1:5	457:459	For the optimal composition ratio of UA:SA (1:5, w/w), the cumulative release of UA was about 101.22 ± 1.50% for 180 min.
34797663	1	50	theme	study	142:146	arg1	aim					130:132	The aim	126:132	The aim of this study	126:146	The aim of this study was to fabricate ursolic acid (UA)-sodium alginate (SA) complexes to improve the dissolution rate and antioxidant abilities.
34797663	4	51	theme	X-ray	542:546	arg1	diffractometry					548:561	Powder X-ray diffractometry	535:561	Powder X-ray diffractometry (PXRD)	535:568	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	4	51	theme	X-ray	542:546	arg1	PXRD					564:567	PXRD	564:567	PXRD	564:567	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	4	52	theme	differential	571:582	arg1	DSC					606:608	DSC	606:608	DSC	606:608	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	4	52	theme	differential	571:582	arg1	calorimetry					593:603	differential scanning calorimetry	571:603	differential scanning calorimetry (DSC)	571:609	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	3	53	theme	UA	450:451	arg1	ratio					441:445	the optimal composition ratio	417:445	the optimal composition ratio of UA:SA (1:5, w/w)	417:465	For the optimal composition ratio of UA:SA (1:5, w/w), the cumulative release of UA was about 101.22 ± 1.50% for 180 min.
34797663	4	54	theme	Powder	535:540	arg1	diffractometry					548:561	Powder X-ray diffractometry	535:561	Powder X-ray diffractometry (PXRD)	535:568	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	4	54	theme	Powder	535:540	arg1	PXRD					564:567	PXRD	564:567	PXRD	564:567	Powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses confirmed that the crystallinity of UA was significantly reduced by forming complexes with SA.
34797663	7	55	theme	promising	1078:1086	arg1	SA					1058:1059	SA	1058:1059	SA	1058:1059	The results indicated that SA could serve as a promising carrier for lipophilic functional food ingredients due to improved solubility and antioxidant activity.
34797663	7	55	theme	promising	1078:1086	arg1	carrier					1088:1094	a promising carrier	1076:1094	a promising carrier for lipophilic functional food ingredients due to improved solubility and antioxidant activity	1076:1189	The results indicated that SA could serve as a promising carrier for lipophilic functional food ingredients due to improved solubility and antioxidant activity.
34797663	5	56	theme	carbonyl	919:926	arg1	group					928:932	the carbonyl group	915:932	the carbonyl group	915:932	By Fourier transform infrared spectroscopy (FTIR) and molecular docking simulations, it was observed that the hydroxyl group in UA formed hydrogen bonding with the carbonyl group in SA.
34797663	5	57	theme	molecular	809:817	arg1	simulations					827:837	molecular docking simulations	809:837	molecular docking simulations	809:837	By Fourier transform infrared spectroscopy (FTIR) and molecular docking simulations, it was observed that the hydroxyl group in UA formed hydrogen bonding with the carbonyl group in SA.
34797663	7	58	theme	lipophilic	1100:1109	arg1	ingredients					1127:1137	lipophilic functional food ingredients	1100:1137	lipophilic functional food ingredients due to improved solubility and antioxidant activity	1100:1189	The results indicated that SA could serve as a promising carrier for lipophilic functional food ingredients due to improved solubility and antioxidant activity.
33875074	4	0	theme	due	482:484	arg1	requirements					469:480	the clinical requirements	456:480	the clinical requirements due to its poor biocompatibility	456:513	However, synthetic nondegradable meshes for POP therapy cannot meet the clinical requirements due to its poor biocompatibility.
33875074	6	1	theme	stem	694:697	arg1	mBMSCs					706:711	mBMSCs	706:711	mBMSCs	706:711	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	6	1	theme	stem	694:697	arg1	cells					699:703	mouse bone marrow-derived mesenchymal stem cells	656:703	mouse bone marrow-derived mesenchymal stem cells (mBMSCs)	656:712	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	0	2	theme	Cell	62:65	arg1	Culture					67:73	Cell Culture	62:73	Cell Culture	62:73	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.
33875074	4	3	theme	poor	493:496	arg1	biocompatibility					498:513	its poor biocompatibility	489:513	its poor biocompatibility	489:513	However, synthetic nondegradable meshes for POP therapy cannot meet the clinical requirements due to its poor biocompatibility.
33875074	5	4	theme	l-lactic	580:587	arg1	poly					575:578	poly	575:578	poly(l-lactic acid)-hyaluronic acid (PLLA/HA)	575:619	Herein, we fabricated electrospun core-shell nanofibers of poly(l-lactic acid)-hyaluronic acid (PLLA/HA).
33875074	5	4	theme	l-lactic	580:587	arg1	acid					589:592	l-lactic acid	580:592	l-lactic acid	580:592	Herein, we fabricated electrospun core-shell nanofibers of poly(l-lactic acid)-hyaluronic acid (PLLA/HA).
33875074	0	5	theme	Pelvic	79:84	arg1	Ligament					86:93	Pelvic Ligament	79:93	Pelvic Ligament	79:93	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.
33875074	2	6	theme	essential	257:265	arg1	role					267:270	an essential role	254:270	an essential role	254:270	Weakening of pelvic ligaments plays an essential role in the pathophysiology of POP.
33875074	6	7	link	marrow-derived	667:680	arg1	mBMSCs					706:711	mBMSCs	706:711	mBMSCs	706:711	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	6	7	link	marrow-derived	667:680	arg1	cells					699:703	mouse bone marrow-derived mesenchymal stem cells	656:703	mouse bone marrow-derived mesenchymal stem cells (mBMSCs)	656:712	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	6	8	theme	tissue	766:771	arg1	engineering					773:783	pelvic ligament tissue engineering	750:783	pelvic ligament tissue engineering	750:783	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	0	9	theme	Core-Shell	0:9	arg1	Poly					11:14	Core-Shell Poly	0:14	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.	0:113	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.
33875074	0	9	theme	Core-Shell	0:9	arg1	acid					25:28	l-lactic acid	16:28	l-lactic acid	16:28	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.
33875074	6	10	theme	mesenchymal	682:692	arg1	mBMSCs					706:711	mBMSCs	706:711	mBMSCs	706:711	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	6	10	theme	mesenchymal	682:692	arg1	cells					699:703	mouse bone marrow-derived mesenchymal stem cells	656:703	mouse bone marrow-derived mesenchymal stem cells (mBMSCs)	656:712	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	0	11	theme	Tissue	95:100	arg1	Engineering					102:112	Tissue Engineering	95:112	Tissue Engineering	95:112	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.
33875074	9	12	from	promising	1320:1328	arg1	engineering					1356:1366	stem cell-based tissue engineering	1333:1366	stem cell-based tissue engineering for pelvic reconstruction	1333:1392	These features suggested that this novel core-shell nanofiber is promising in stem cell-based tissue engineering for pelvic reconstruction.
33875074	5	13	theme	-hyaluronic	594:604	arg1	PLLA/HA					612:618	PLLA/HA	612:618	PLLA/HA	612:618	Herein, we fabricated electrospun core-shell nanofibers of poly(l-lactic acid)-hyaluronic acid (PLLA/HA).
33875074	5	13	theme	-hyaluronic	594:604	arg1	acid					606:609	-hyaluronic acid	594:609	poly(l-lactic acid)-hyaluronic acid (PLLA/HA)	575:619	Herein, we fabricated electrospun core-shell nanofibers of poly(l-lactic acid)-hyaluronic acid (PLLA/HA).
33875074	6	14	theme	marrow-derived	667:680	arg1	mBMSCs					706:711	mBMSCs	706:711	mBMSCs	706:711	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	6	14	theme	marrow-derived	667:680	arg1	cells					699:703	mouse bone marrow-derived mesenchymal stem cells	656:703	mouse bone marrow-derived mesenchymal stem cells (mBMSCs)	656:712	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	3	15	theme	synthetic	314:322	arg1	materials					324:332	synthetic materials	314:332	synthetic materials	314:332	Currently, synthetic materials are widely applied for pelvic reconstructive surgery.
33875074	8	16	theme	PLLA/HA	1049:1055	arg1	nanofibers					1057:1066	PLLA/HA nanofibers	1049:1066	PLLA/HA nanofibers	1049:1066	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	6	17	theme	pelvic	750:755	arg1	engineering					773:783	pelvic ligament tissue engineering	750:783	pelvic ligament tissue engineering	750:783	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	2	18	theme	ligaments	238:246	arg1	Weakening					218:226	Weakening	218:226	Weakening of pelvic ligaments	218:246	Weakening of pelvic ligaments plays an essential role in the pathophysiology of POP.
33875074	6	19	theme	bone	662:665	arg1	mBMSCs					706:711	mBMSCs	706:711	mBMSCs	706:711	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	6	19	theme	bone	662:665	arg1	cells					699:703	mouse bone marrow-derived mesenchymal stem cells	656:703	mouse bone marrow-derived mesenchymal stem cells (mBMSCs)	656:712	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	0	20	theme	Poly	11:14	arg1	Nanofibers					47:56	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers	0:56	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.	0:113	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.
33875074	4	21	theme	clinical	460:467	arg1	requirements					469:480	the clinical requirements	456:480	the clinical requirements due to its poor biocompatibility	456:513	However, synthetic nondegradable meshes for POP therapy cannot meet the clinical requirements due to its poor biocompatibility.
33875074	8	22	theme	more	1078:1081	arg1	function					1092:1099	more cellular function	1078:1099	more cellular function	1078:1099	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	0	23	dep	Culture	67:73	arg1	Engineering					102:112	Tissue Engineering	95:112	Tissue Engineering	95:112	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.
33875074	6	24	theme	mouse	656:660	arg1	mBMSCs					706:711	mBMSCs	706:711	mBMSCs	706:711	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	6	24	theme	mouse	656:660	arg1	cells					699:703	mouse bone marrow-derived mesenchymal stem cells	656:703	mouse bone marrow-derived mesenchymal stem cells (mBMSCs)	656:712	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	3	25	theme	pelvic	357:362	arg1	surgery					379:385	pelvic reconstructive surgery	357:385	pelvic reconstructive surgery	357:385	Currently, synthetic materials are widely applied for pelvic reconstructive surgery.
33875074	9	26	theme	tissue	1349:1354	arg1	engineering					1356:1366	stem cell-based tissue engineering	1333:1366	stem cell-based tissue engineering for pelvic reconstruction	1333:1392	These features suggested that this novel core-shell nanofiber is promising in stem cell-based tissue engineering for pelvic reconstruction.
33875074	9	27	theme	cell-based	1338:1347	arg1	engineering					1356:1366	stem cell-based tissue engineering	1333:1366	stem cell-based tissue engineering for pelvic reconstruction	1333:1392	These features suggested that this novel core-shell nanofiber is promising in stem cell-based tissue engineering for pelvic reconstruction.
33875074	5	28	theme	poly	575:578	arg1	nanofibers					561:570	electrospun core-shell nanofibers	538:570	electrospun core-shell nanofibers of poly(l-lactic acid)-hyaluronic acid (PLLA/HA)	538:619	Herein, we fabricated electrospun core-shell nanofibers of poly(l-lactic acid)-hyaluronic acid (PLLA/HA).
33875074	7	29	theme	core-shell	862:871	arg1	nanofibers					883:892	the core-shell structure nanofibers	858:892	the core-shell structure nanofibers	858:892	The cellular responses on the composite nanofibers showed that the core-shell structure nanofibers displayed with excellent biocompatibility and enhanced cellular activity without cytotoxicity.
33875074	0	30	theme	l-lactic	16:23	arg1	Poly					11:14	Core-Shell Poly	0:14	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.	0:113	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.
33875074	0	30	theme	l-lactic	16:23	arg1	acid					25:28	l-lactic acid	16:28	l-lactic acid	16:28	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.
33875074	6	31	theme	cellular	728:735	arg1	response					737:744	the cellular response	724:744	the cellular response	724:744	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	7	32	theme	cellular	799:806	arg1	responses					808:816	The cellular responses	795:816	The cellular responses on the composite nanofibers	795:844	The cellular responses on the composite nanofibers showed that the core-shell structure nanofibers displayed with excellent biocompatibility and enhanced cellular activity without cytotoxicity.
33875074	8	33	theme	gene	1208:1211	arg1	Col1a1					1231:1236	Col1a1	1231:1236	Col1a1	1231:1236	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	33	theme	gene	1208:1211	arg1	markers					1213:1219	pelvic ligament-related gene markers	1184:1219	pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc	1184:1252	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	33	theme	gene	1208:1211	arg1	Tnc					1250:1252	Tnc	1250:1252	Tnc	1250:1252	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	33	theme	gene	1208:1211	arg1	Col1a3					1239:1244	Col1a3	1239:1244	Col1a3	1239:1244	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	34	theme	cellular	1083:1090	arg1	function					1092:1099	more cellular function	1078:1099	more cellular function	1078:1099	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	4	35	theme	POP	432:434	arg1	therapy					436:442	POP therapy	432:442	POP therapy	432:442	However, synthetic nondegradable meshes for POP therapy cannot meet the clinical requirements due to its poor biocompatibility.
33875074	9	36	theme	pelvic	1372:1377	arg1	reconstruction					1379:1392	pelvic reconstruction	1372:1392	pelvic reconstruction	1372:1392	These features suggested that this novel core-shell nanofiber is promising in stem cell-based tissue engineering for pelvic reconstruction.
33875074	7	37	theme	cellular	949:956	arg1	activity					958:965	cellular activity	949:965	cellular activity	949:965	The cellular responses on the composite nanofibers showed that the core-shell structure nanofibers displayed with excellent biocompatibility and enhanced cellular activity without cytotoxicity.
33875074	7	38	theme	composite	825:833	arg1	nanofibers					835:844	the composite nanofibers	821:844	the composite nanofibers	821:844	The cellular responses on the composite nanofibers showed that the core-shell structure nanofibers displayed with excellent biocompatibility and enhanced cellular activity without cytotoxicity.
33875074	9	39	theme	core-shell	1296:1305	arg1	nanofiber					1307:1315	this novel core-shell nanofiber	1285:1315	this novel core-shell nanofiber	1285:1315	These features suggested that this novel core-shell nanofiber is promising in stem cell-based tissue engineering for pelvic reconstruction.
33875074	1	40	theme	common	170:175	arg1	diseases					185:192	the most common serious diseases	161:192	the most common serious diseases affecting parous women	161:215	Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women.
33875074	8	41	theme	chain	1155:1159	arg1	RT-qPCR					1171:1177	RT-qPCR	1171:1177	RT-qPCR	1171:1177	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	41	theme	chain	1155:1159	arg1	reaction					1161:1168	the quantitative real-time polymerase chain reaction	1117:1168	the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc	1117:1252	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	42	theme	PLLA	1013:1016	arg1	nanofibers					1018:1027	PLLA nanofibers	1013:1027	PLLA nanofibers seeded with mBMSCs	1013:1046	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	1	43	theme	serious	177:183	arg1	diseases					185:192	the most common serious diseases	161:192	the most common serious diseases affecting parous women	161:215	Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women.
33875074	0	44	theme	Acid	42:45	arg1	Nanofibers					47:56	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers	0:56	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.	0:113	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.
33875074	8	45	theme	real-time	1134:1142	arg1	RT-qPCR					1171:1177	RT-qPCR	1171:1177	RT-qPCR	1171:1177	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	45	theme	real-time	1134:1142	arg1	reaction					1161:1168	the quantitative real-time polymerase chain reaction	1117:1168	the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc	1117:1252	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	0	46	theme	-Hyaluronic	30:40	arg1	Nanofibers					47:56	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers	0:56	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.	0:113	Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.
33875074	4	47	theme	synthetic	397:405	arg1	meshes					421:426	synthetic nondegradable meshes	397:426	synthetic nondegradable meshes for POP therapy	397:442	However, synthetic nondegradable meshes for POP therapy cannot meet the clinical requirements due to its poor biocompatibility.
33875074	5	48	theme	electrospun	538:548	arg1	nanofibers					561:570	electrospun core-shell nanofibers	538:570	electrospun core-shell nanofibers of poly(l-lactic acid)-hyaluronic acid (PLLA/HA)	538:619	Herein, we fabricated electrospun core-shell nanofibers of poly(l-lactic acid)-hyaluronic acid (PLLA/HA).
33875074	7	49	theme	excellent	909:917	arg1	biocompatibility					919:934	excellent biocompatibility	909:934	excellent biocompatibility	909:934	The cellular responses on the composite nanofibers showed that the core-shell structure nanofibers displayed with excellent biocompatibility and enhanced cellular activity without cytotoxicity.
33875074	8	50	theme	quantitative	1121:1132	arg1	RT-qPCR					1171:1177	RT-qPCR	1171:1177	RT-qPCR	1171:1177	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	50	theme	quantitative	1121:1132	arg1	reaction					1161:1168	the quantitative real-time polymerase chain reaction	1117:1168	the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc	1117:1252	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	7	51	from	responses	808:816	arg1	nanofibers					835:844	the composite nanofibers	821:844	the composite nanofibers	821:844	The cellular responses on the composite nanofibers showed that the core-shell structure nanofibers displayed with excellent biocompatibility and enhanced cellular activity without cytotoxicity.
33875074	2	52	theme	pelvic	231:236	arg1	ligaments					238:246	pelvic ligaments	231:246	pelvic ligaments	231:246	Weakening of pelvic ligaments plays an essential role in the pathophysiology of POP.
33875074	5	53	theme	core-shell	550:559	arg1	nanofibers					561:570	electrospun core-shell nanofibers	538:570	electrospun core-shell nanofibers of poly(l-lactic acid)-hyaluronic acid (PLLA/HA)	538:619	Herein, we fabricated electrospun core-shell nanofibers of poly(l-lactic acid)-hyaluronic acid (PLLA/HA).
33875074	1	54	theme	Pelvic	115:120	arg1	POP					138:140	POP	138:140	POP	138:140	Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women.
33875074	1	54	theme	Pelvic	115:120	arg1	prolapse					128:135	Pelvic organ prolapse	115:135	Pelvic organ prolapse (POP)	115:141	Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women.
33875074	1	55	theme	diseases	185:192	arg1	one					154:156	one	154:156	one	154:156	Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women.
33875074	1	55	theme	diseases	185:192	arg1	diseases					185:192	the most common serious diseases	161:192	the most common serious diseases affecting parous women	161:215	Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women.
33875074	8	56	theme	pelvic	1184:1189	arg1	Col1a1					1231:1236	Col1a1	1231:1236	Col1a1	1231:1236	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	56	theme	pelvic	1184:1189	arg1	markers					1213:1219	pelvic ligament-related gene markers	1184:1219	pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc	1184:1252	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	56	theme	pelvic	1184:1189	arg1	Tnc					1250:1252	Tnc	1250:1252	Tnc	1250:1252	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	56	theme	pelvic	1184:1189	arg1	Col1a3					1239:1244	Col1a3	1239:1244	Col1a3	1239:1244	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	1	57	theme	organ	122:126	arg1	POP					138:140	POP	138:140	POP	138:140	Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women.
33875074	1	57	theme	organ	122:126	arg1	prolapse					128:135	Pelvic organ prolapse	115:135	Pelvic organ prolapse (POP)	115:141	Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women.
33875074	6	58	theme	ligament	757:764	arg1	engineering					773:783	pelvic ligament tissue engineering	750:783	pelvic ligament tissue engineering	750:783	After that, we combined them with mouse bone marrow-derived mesenchymal stem cells (mBMSCs) to assess the cellular response and pelvic ligament tissue engineering in vitro.
33875074	2	59	theme	POP	298:300	arg1	pathophysiology					279:293	the pathophysiology	275:293	the pathophysiology of POP	275:300	Weakening of pelvic ligaments plays an essential role in the pathophysiology of POP.
33875074	8	60	theme	polymerase	1144:1153	arg1	RT-qPCR					1171:1177	RT-qPCR	1171:1177	RT-qPCR	1171:1177	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	60	theme	polymerase	1144:1153	arg1	reaction					1161:1168	the quantitative real-time polymerase chain reaction	1117:1168	the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc	1117:1252	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	4	61	theme	nondegradable	407:419	arg1	meshes					421:426	synthetic nondegradable meshes	397:426	synthetic nondegradable meshes for POP therapy	397:442	However, synthetic nondegradable meshes for POP therapy cannot meet the clinical requirements due to its poor biocompatibility.
33875074	9	62	from	engineering	1356:1366	arg1	promising					1320:1328	promising	1320:1328	promising	1320:1328	These features suggested that this novel core-shell nanofiber is promising in stem cell-based tissue engineering for pelvic reconstruction.
33875074	7	63	theme	structure	873:881	arg1	nanofibers					883:892	the core-shell structure nanofibers	858:892	the core-shell structure nanofibers	858:892	The cellular responses on the composite nanofibers showed that the core-shell structure nanofibers displayed with excellent biocompatibility and enhanced cellular activity without cytotoxicity.
33875074	1	64	theme	parous	204:209	arg1	women					211:215	parous women	204:215	parous women	204:215	Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women.
33875074	3	65	theme	reconstructive	364:377	arg1	surgery					379:385	pelvic reconstructive surgery	357:385	pelvic reconstructive surgery	357:385	Currently, synthetic materials are widely applied for pelvic reconstructive surgery.
33875074	9	66	theme	novel	1290:1294	arg1	nanofiber					1307:1315	this novel core-shell nanofiber	1285:1315	this novel core-shell nanofiber	1285:1315	These features suggested that this novel core-shell nanofiber is promising in stem cell-based tissue engineering for pelvic reconstruction.
33875074	8	67	theme	ligament-related	1191:1206	arg1	Col1a1					1231:1236	Col1a1	1231:1236	Col1a1	1231:1236	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	67	theme	ligament-related	1191:1206	arg1	markers					1213:1219	pelvic ligament-related gene markers	1184:1219	pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc	1184:1252	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	67	theme	ligament-related	1191:1206	arg1	Tnc					1250:1252	Tnc	1250:1252	Tnc	1250:1252	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	8	67	theme	ligament-related	1191:1206	arg1	Col1a3					1239:1244	Col1a3	1239:1244	Col1a3	1239:1244	Moreover, compared with PLLA nanofibers seeded with mBMSCs, PLLA/HA nanofibers exhibited more cellular function, as revealed by the quantitative real-time polymerase chain reaction (RT-qPCR) for pelvic ligament-related gene markers including Col1a1, Col1a3 and Tnc.
33875074	5	68	dep	poly	575:578	arg1	PLLA/HA					612:618	PLLA/HA	612:618	PLLA/HA	612:618	Herein, we fabricated electrospun core-shell nanofibers of poly(l-lactic acid)-hyaluronic acid (PLLA/HA).
33875074	5	68	dep	poly	575:578	arg1	acid					606:609	-hyaluronic acid	594:609	poly(l-lactic acid)-hyaluronic acid (PLLA/HA)	575:619	Herein, we fabricated electrospun core-shell nanofibers of poly(l-lactic acid)-hyaluronic acid (PLLA/HA).
34299163	8	0	theme	all-atom	1415:1422	arg1	solvent					1433:1439	all-atom explicit solvent	1415:1439	all-atom explicit solvent MD simulations	1415:1454	CVLS also deduced the preferred composition of the high specificity hexasaccharides, which were further assessed in all-atom explicit solvent MD simulations.
34299163	6	1	dep	affinity	1156:1163	arg1	the					1147:1149	the	1147:1149	the	1147:1149	CVLS predicted that both the chain length and level of sulfation are critical for the high affinity and high specificity recognition of TGF-β2.
34299163	6	2	theme	high	1151:1154	arg1	affinity					1156:1163	high affinity	1151:1163	high affinity	1151:1163	CVLS predicted that both the chain length and level of sulfation are critical for the high affinity and high specificity recognition of TGF-β2.
34299163	10	3	theme	high	1639:1642	arg1	affinity					1644:1651	high affinity	1639:1651	high affinity	1639:1651	More specifically, the highly selective CS chains were found to engage the TGF-β2 monomer with high affinity.
34299163	1	4	theme	superfamily	179:189	arg1	factor-beta					127:137	Transforming growth factor-beta	107:137	Transforming growth factor-beta (TGF-β)	107:145	Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear.
34299163	1	4	theme	superfamily	179:189	arg1	member					150:155	a member	148:155	a member of the TGF-β cytokine superfamily	148:189	Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear.
34299163	12	5	theme	possible	1821:1828	arg1	oligosaccharides					1833:1848	all possible CS oligosaccharides	1817:1848	all possible CS oligosaccharides	1817:1848	In the process, it led to the generation of the in silico library of all possible CS oligosaccharides, which can be used for advanced studies on other protein-CS systems.
34299163	3	6	used	utilized	495:502	arg2	we					492:493	we	492:493	we	492:493	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	11	7	theme	key	1681:1683	arg1	principles					1685:1694	key principles	1681:1694	key principles of recognition	1681:1709	Overall, this work present key principles of recognition with regard to the TGF-β2-CS system.
34299163	3	8	theme	virtual	536:542	arg1	approach					569:576	the computational combinatorial virtual library screening (CVLS) approach	504:576	the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations	504:627	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	12	9	theme	oligosaccharides	1833:1848	arg1	library					1806:1812	the in silico library	1792:1812	the in silico library of all possible CS oligosaccharides	1792:1848	In the process, it led to the generation of the in silico library of all possible CS oligosaccharides, which can be used for advanced studies on other protein-CS systems.
34299163	7	10	theme	GAG	1276:1278	arg1	binding					1280:1286	GAG binding	1276:1286	GAG binding	1276:1286	Interestingly, CVLS led to identification of two distinct sites of GAG binding on TGF-β2.
34299163	1	11	theme	growth	120:125	arg1	TGF-β					140:144	TGF-β	140:144	TGF-β	140:144	Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear.
34299163	1	11	theme	growth	120:125	arg1	factor-beta					127:137	Transforming growth factor-beta	107:137	Transforming growth factor-beta (TGF-β)	107:145	Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear.
34299163	1	11	theme	growth	120:125	arg1	member					150:155	a member	148:155	a member of the TGF-β cytokine superfamily	148:189	Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear.
34299163	3	12	theme	computational	508:520	arg1	approach					569:576	the computational combinatorial virtual library screening (CVLS) approach	504:576	the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations	504:627	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	7	13	theme	sites	1267:1271	arg1	identification					1236:1249	identification	1236:1249	identification of two distinct sites of GAG binding on TGF-β2	1236:1296	Interestingly, CVLS led to identification of two distinct sites of GAG binding on TGF-β2.
34299163	13	14	theme	unique	1967:1972	arg1	sequences					1977:1985	unique CS sequences	1967:1985	unique CS sequences that are predicted to selectively recognize TGF-β2 and may out-compete common natural CS biopolymers	1967:2086	Finally, the study led to the identification of unique CS sequences that are predicted to selectively recognize TGF-β2 and may out-compete common natural CS biopolymers.
34299163	3	15	theme	CVLS	563:566	arg1	approach					569:576	the computational combinatorial virtual library screening (CVLS) approach	504:576	the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations	504:627	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	3	16	theme	screening	552:560	arg1	approach					569:576	the computational combinatorial virtual library screening (CVLS) approach	504:576	the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations	504:627	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	5	17	theme	oligosaccharides	805:820	arg1	library					786:792	This library	781:792	This library of 1752 CS oligosaccharides	781:820	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	6	18	theme	specificity	1174:1184	arg1	recognition					1186:1196	the high affinity and high specificity recognition	1147:1196	the high affinity and high specificity recognition of TGF-β2	1147:1206	CVLS predicted that both the chain length and level of sulfation are critical for the high affinity and high specificity recognition of TGF-β2.
34299163	10	19	with	monomer	1626:1632	arg1	affinity					1644:1651	high affinity	1639:1651	high affinity	1639:1651	More specifically, the highly selective CS chains were found to engage the TGF-β2 monomer with high affinity.
34299163	8	20	theme	specificity	1355:1365	arg1	hexasaccharides					1367:1381	the high specificity hexasaccharides	1346:1381	the high specificity hexasaccharides	1346:1381	CVLS also deduced the preferred composition of the high specificity hexasaccharides, which were further assessed in all-atom explicit solvent MD simulations.
34299163	4	21	theme	possible	634:641	arg1	oligosaccharides					646:661	All possible CS oligosaccharides	630:661	All possible CS oligosaccharides	630:661	All possible CS oligosaccharides were generated in a combinatorial manner to give 24 di- (CS02), 192 tetra- (CS04), and 1536 hexa- (CS06) saccharides.
34299163	0	22	theme	Factor-β2-Chondroitin	69:89	arg1	Sulfate					91:97	Transforming Growth Factor-β2-Chondroitin Sulfate	49:97	Transforming Growth Factor-β2-Chondroitin Sulfate System	49:104	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.
34299163	0	23	theme	System	99:104	arg1	Study					40:44	Combinatorial Virtual Library Screening Study	0:44	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.	0:105	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.
34299163	1	24	theme	TGF-β	164:168	arg1	superfamily					179:189	the TGF-β cytokine superfamily	160:189	the TGF-β cytokine superfamily	160:189	Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear.
34299163	5	25	theme	dual	866:869	arg1	algorithm					883:891	the dual filter CVLS algorithm	862:891	the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity	862:1062	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	3	26	from	approach	569:576	arg1	tandem					581:586	tandem	581:586	tandem	581:586	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	5	27	theme	surrogate	997:1005	arg1	markers					1007:1013	surrogate markers	997:1013	surrogate markers for in silico affinity and in silico specificity	997:1062	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	5	27	theme	surrogate	997:1005	arg1	root-mean-square-difference					920:946	root-mean-square-difference	920:946	root-mean-square-difference	920:946	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	5	27	theme	surrogate	997:1005	arg1	GOLDScore					906:914	GOLDScore	906:914	GOLDScore	906:914	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	5	28	theme	CVLS	878:881	arg1	algorithm					883:891	the dual filter CVLS algorithm	862:891	the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity	862:1062	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	7	29	from	identification	1236:1249	arg1	TGF-β2					1291:1296	TGF-β2	1291:1296	TGF-β2	1291:1296	Interestingly, CVLS led to identification of two distinct sites of GAG binding on TGF-β2.
34299163	5	30	dep	in	1042:1043	arg1	silico					1045:1050	silico	1045:1050	silico	1045:1050	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	2	31	theme	milk	347:350	arg1	TGF-β2					352:357	preterm human milk TGF-β2	333:357	preterm human milk TGF-β2	333:357	In a recent study, we found that preterm human milk TGF-β2 is sequestered by chondroitin sulfate (CS) in its proteoglycan form.
34299163	0	32	theme	Combinatorial	0:12	arg1	Study					40:44	Combinatorial Virtual Library Screening Study	0:44	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.	0:105	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.
34299163	13	33	theme	natural	2065:2071	arg1	biopolymers					2076:2086	common natural CS biopolymers	2058:2086	common natural CS biopolymers	2058:2086	Finally, the study led to the identification of unique CS sequences that are predicted to selectively recognize TGF-β2 and may out-compete common natural CS biopolymers.
34299163	9	34	theme	MD	1461:1462	arg1	results					1464:1470	The MD results	1457:1470	The MD results	1457:1470	The MD results confirmed that both sites of binding form stable GAG-protein complexes.
34299163	8	35	theme	solvent	1433:1439	arg1	simulations					1444:1454	all-atom explicit solvent MD simulations	1415:1454	all-atom explicit solvent MD simulations	1415:1454	CVLS also deduced the preferred composition of the high specificity hexasaccharides, which were further assessed in all-atom explicit solvent MD simulations.
34299163	10	36	theme	selective	1574:1582	arg1	chains					1587:1592	the highly selective CS chains	1563:1592	the highly selective CS chains	1563:1592	More specifically, the highly selective CS chains were found to engage the TGF-β2 monomer with high affinity.
34299163	0	37	theme	Library	22:28	arg1	Study					40:44	Combinatorial Virtual Library Screening Study	0:44	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.	0:105	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.
34299163	7	38	from	sites	1267:1271	arg1	TGF-β2					1291:1296	TGF-β2	1291:1296	TGF-β2	1291:1296	Interestingly, CVLS led to identification of two distinct sites of GAG binding on TGF-β2.
34299163	12	39	theme	other	1893:1897	arg1	systems					1910:1916	other protein-CS systems	1893:1916	other protein-CS systems	1893:1916	In the process, it led to the generation of the in silico library of all possible CS oligosaccharides, which can be used for advanced studies on other protein-CS systems.
34299163	5	40	dep	in	1019:1020	arg1	silico					1022:1027	silico	1022:1027	silico	1022:1027	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	2	41	theme	proteoglycan	409:420	arg1	form					422:425	its proteoglycan form	405:425	its proteoglycan form	405:425	In a recent study, we found that preterm human milk TGF-β2 is sequestered by chondroitin sulfate (CS) in its proteoglycan form.
34299163	3	42	theme	molecular	593:601	arg1	dynamics					603:610	molecular dynamics	593:610	molecular dynamics (MD) simulations	593:627	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	3	42	theme	molecular	593:601	arg1	MD					613:614	MD	613:614	MD	613:614	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	11	43	theme	TGF-β2-CS	1730:1738	arg1	system					1740:1745	the TGF-β2-CS system	1726:1745	the TGF-β2-CS system	1726:1745	Overall, this work present key principles of recognition with regard to the TGF-β2-CS system.
34299163	0	44	theme	Transforming	49:60	arg1	Sulfate					91:97	Transforming Growth Factor-β2-Chondroitin Sulfate	49:97	Transforming Growth Factor-β2-Chondroitin Sulfate System	49:104	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.
34299163	2	45	theme	recent	305:310	arg1	study					312:316	a recent study	303:316	a recent study	303:316	In a recent study, we found that preterm human milk TGF-β2 is sequestered by chondroitin sulfate (CS) in its proteoglycan form.
34299163	1	46	theme	sulfated	212:219	arg1	GAGs					241:244	GAGs	241:244	GAGs	241:244	Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear.
34299163	1	46	theme	sulfated	212:219	arg1	glycosaminoglycans					221:238	sulfated glycosaminoglycans	212:238	sulfated glycosaminoglycans (GAGs)	212:245	Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear.
34299163	12	47	used	used	1864:1867	arg2	generation					1778:1787	the generation	1774:1787	the generation	1774:1787	In the process, it led to the generation of the in silico library of all possible CS oligosaccharides, which can be used for advanced studies on other protein-CS systems.
34299163	10	48	theme	TGF-β2	1619:1624	arg1	monomer					1626:1632	the TGF-β2 monomer	1615:1632	the TGF-β2 monomer with high affinity	1615:1651	More specifically, the highly selective CS chains were found to engage the TGF-β2 monomer with high affinity.
34299163	12	49	from	studies	1882:1888	arg1	systems					1910:1916	other protein-CS systems	1893:1916	other protein-CS systems	1893:1916	In the process, it led to the generation of the in silico library of all possible CS oligosaccharides, which can be used for advanced studies on other protein-CS systems.
34299163	9	50	theme	GAG-protein	1521:1531	arg1	complexes					1533:1541	stable GAG-protein complexes	1514:1541	stable GAG-protein complexes	1514:1541	The MD results confirmed that both sites of binding form stable GAG-protein complexes.
34299163	12	51	theme	protein-CS	1899:1908	arg1	systems					1910:1916	other protein-CS systems	1893:1916	other protein-CS systems	1893:1916	In the process, it led to the generation of the in silico library of all possible CS oligosaccharides, which can be used for advanced studies on other protein-CS systems.
34299163	6	52	theme	high	1169:1172	arg1	specificity					1174:1184	high specificity	1169:1184	high specificity	1169:1184	CVLS predicted that both the chain length and level of sulfation are critical for the high affinity and high specificity recognition of TGF-β2.
34299163	13	53	theme	sequences	1977:1985	arg1	identification					1949:1962	the identification	1945:1962	the identification of unique CS sequences that are predicted to selectively recognize TGF-β2 and may out-compete common natural CS biopolymers	1945:2086	Finally, the study led to the identification of unique CS sequences that are predicted to selectively recognize TGF-β2 and may out-compete common natural CS biopolymers.
34299163	12	54	theme	advanced	1873:1880	arg1	studies					1882:1888	advanced studies	1873:1888	advanced studies on other protein-CS systems	1873:1916	In the process, it led to the generation of the in silico library of all possible CS oligosaccharides, which can be used for advanced studies on other protein-CS systems.
34299163	6	55	theme	affinity	1156:1163	arg1	recognition					1186:1196	the high affinity and high specificity recognition	1147:1196	the high affinity and high specificity recognition of TGF-β2	1147:1206	CVLS predicted that both the chain length and level of sulfation are critical for the high affinity and high specificity recognition of TGF-β2.
34299163	3	56	theme	interaction	479:489	arg1	basis					456:460	the molecular basis	442:460	the molecular basis of the TGF-β2-CS interaction	442:489	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	5	57	dep	GOLDScore	906:914	arg1	the					902:904	the	902:904	the	902:904	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	1	58	theme	cytokine	170:177	arg1	superfamily					179:189	the TGF-β cytokine superfamily	160:189	the TGF-β cytokine superfamily	160:189	Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear.
34299163	3	59	theme	combinatorial	522:534	arg1	approach					569:576	the computational combinatorial virtual library screening (CVLS) approach	504:576	the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations	504:627	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	4	60	theme	hexa-	755:759	arg1	saccharides					768:778	1536 hexa- (CS06) saccharides	750:778	1536 hexa- (CS06) saccharides	750:778	All possible CS oligosaccharides were generated in a combinatorial manner to give 24 di- (CS02), 192 tetra- (CS04), and 1536 hexa- (CS06) saccharides.
34299163	12	61	theme	CS	1830:1831	arg1	oligosaccharides					1833:1848	all possible CS oligosaccharides	1817:1848	all possible CS oligosaccharides	1817:1848	In the process, it led to the generation of the in silico library of all possible CS oligosaccharides, which can be used for advanced studies on other protein-CS systems.
34299163	2	62	theme	preterm	333:339	arg1	TGF-β2					352:357	preterm human milk TGF-β2	333:357	preterm human milk TGF-β2	333:357	In a recent study, we found that preterm human milk TGF-β2 is sequestered by chondroitin sulfate (CS) in its proteoglycan form.
34299163	8	63	theme	preferred	1321:1329	arg1	composition					1331:1341	the preferred composition	1317:1341	the preferred composition of the high specificity hexasaccharides, which were further assessed in all-atom explicit solvent MD simulations	1317:1454	CVLS also deduced the preferred composition of the high specificity hexasaccharides, which were further assessed in all-atom explicit solvent MD simulations.
34299163	7	64	theme	binding	1280:1286	arg1	sites					1267:1271	two distinct sites	1254:1271	two distinct sites of GAG binding on TGF-β2	1254:1296	Interestingly, CVLS led to identification of two distinct sites of GAG binding on TGF-β2.
34299163	7	64	theme	binding	1280:1286	arg1	binding					1280:1286	GAG binding	1276:1286	GAG binding	1276:1286	Interestingly, CVLS led to identification of two distinct sites of GAG binding on TGF-β2.
34299163	12	65	theme	in	1796:1797	arg1	library					1806:1812	the in silico library	1792:1812	the in silico library of all possible CS oligosaccharides	1792:1848	In the process, it led to the generation of the in silico library of all possible CS oligosaccharides, which can be used for advanced studies on other protein-CS systems.
34299163	6	66	theme	TGF-β2	1201:1206	arg1	recognition					1186:1196	the high affinity and high specificity recognition	1147:1196	the high affinity and high specificity recognition of TGF-β2	1147:1206	CVLS predicted that both the chain length and level of sulfation are critical for the high affinity and high specificity recognition of TGF-β2.
34299163	13	67	theme	CS	1974:1975	arg1	sequences					1977:1985	unique CS sequences	1967:1985	unique CS sequences that are predicted to selectively recognize TGF-β2 and may out-compete common natural CS biopolymers	1967:2086	Finally, the study led to the identification of unique CS sequences that are predicted to selectively recognize TGF-β2 and may out-compete common natural CS biopolymers.
34299163	3	68	theme	library	544:550	arg1	approach					569:576	the computational combinatorial virtual library screening (CVLS) approach	504:576	the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations	504:627	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	5	69	theme	CS	802:803	arg1	oligosaccharides					805:820	1752 CS oligosaccharides	797:820	1752 CS oligosaccharides	797:820	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	12	70	theme	library	1806:1812	arg1	generation					1778:1787	the generation	1774:1787	the generation	1774:1787	In the process, it led to the generation of the in silico library of all possible CS oligosaccharides, which can be used for advanced studies on other protein-CS systems.
34299163	8	71	theme	high	1350:1353	arg1	hexasaccharides					1367:1381	the high specificity hexasaccharides	1346:1381	the high specificity hexasaccharides	1346:1381	CVLS also deduced the preferred composition of the high specificity hexasaccharides, which were further assessed in all-atom explicit solvent MD simulations.
34299163	7	72	theme	distinct	1258:1265	arg1	sites					1267:1271	two distinct sites	1254:1271	two distinct sites of GAG binding on TGF-β2	1254:1296	Interestingly, CVLS led to identification of two distinct sites of GAG binding on TGF-β2.
34299163	7	72	theme	distinct	1258:1265	arg1	binding					1280:1286	GAG binding	1276:1286	GAG binding	1276:1286	Interestingly, CVLS led to identification of two distinct sites of GAG binding on TGF-β2.
34299163	11	73	theme	recognition	1699:1709	arg1	principles					1685:1694	key principles	1681:1694	key principles of recognition	1681:1709	Overall, this work present key principles of recognition with regard to the TGF-β2-CS system.
34299163	8	74	theme	hexasaccharides	1367:1381	arg1	composition					1331:1341	the preferred composition	1317:1341	the preferred composition of the high specificity hexasaccharides, which were further assessed in all-atom explicit solvent MD simulations	1317:1454	CVLS also deduced the preferred composition of the high specificity hexasaccharides, which were further assessed in all-atom explicit solvent MD simulations.
34299163	6	75	theme	chain	1094:1098	arg1	length					1100:1105	the chain length	1090:1105	the chain length	1090:1105	CVLS predicted that both the chain length and level of sulfation are critical for the high affinity and high specificity recognition of TGF-β2.
34299163	6	75	theme	chain	1094:1098	arg1	critical					1134:1141	critical	1134:1141	critical	1134:1141	CVLS predicted that both the chain length and level of sulfation are critical for the high affinity and high specificity recognition of TGF-β2.
34299163	0	76	theme	Sulfate	91:97	arg1	System					99:104	Transforming Growth Factor-β2-Chondroitin Sulfate System	49:104	Transforming Growth Factor-β2-Chondroitin Sulfate System	49:104	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.
34299163	7	77	from	TGF-β2	1291:1296	arg1	identification					1236:1249	identification	1236:1249	identification of two distinct sites of GAG binding on TGF-β2	1236:1296	Interestingly, CVLS led to identification of two distinct sites of GAG binding on TGF-β2.
34299163	5	78	used	used	989:992	arg2	RMSD					949:952	RMSD	949:952	RMSD	949:952	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	5	78	used	used	989:992	arg2	root-mean-square-difference					920:946	root-mean-square-difference	920:946	root-mean-square-difference	920:946	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	5	78	used	used	989:992	arg2	markers					1007:1013	surrogate markers	997:1013	surrogate markers for in silico affinity and in silico specificity	997:1062	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	5	78	used	used	989:992	arg2	GOLDScore					906:914	GOLDScore	906:914	GOLDScore	906:914	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	5	79	theme	in	1019:1020	arg1	affinity					1029:1036	in silico affinity	1019:1036	in silico affinity	1019:1036	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	4	80	theme	CS	643:644	arg1	oligosaccharides					646:661	All possible CS oligosaccharides	630:661	All possible CS oligosaccharides	630:661	All possible CS oligosaccharides were generated in a combinatorial manner to give 24 di- (CS02), 192 tetra- (CS04), and 1536 hexa- (CS06) saccharides.
34299163	12	81	dep	in	1796:1797	arg1	silico					1799:1804	silico	1799:1804	silico	1799:1804	In the process, it led to the generation of the in silico library of all possible CS oligosaccharides, which can be used for advanced studies on other protein-CS systems.
34299163	5	82	theme	filter	871:876	arg1	algorithm					883:891	the dual filter CVLS algorithm	862:891	the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity	862:1062	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	8	83	theme	explicit	1424:1431	arg1	solvent					1433:1439	all-atom explicit solvent	1415:1439	all-atom explicit solvent MD simulations	1415:1454	CVLS also deduced the preferred composition of the high specificity hexasaccharides, which were further assessed in all-atom explicit solvent MD simulations.
34299163	0	84	theme	Virtual	14:20	arg1	Study					40:44	Combinatorial Virtual Library Screening Study	0:44	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.	0:105	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.
34299163	1	85	theme	Transforming	107:118	arg1	TGF-β					140:144	TGF-β	140:144	TGF-β	140:144	Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear.
34299163	1	85	theme	Transforming	107:118	arg1	factor-beta					127:137	Transforming growth factor-beta	107:137	Transforming growth factor-beta (TGF-β)	107:145	Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear.
34299163	1	85	theme	Transforming	107:118	arg1	member					150:155	a member	148:155	a member of the TGF-β cytokine superfamily	148:189	Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear.
34299163	8	86	theme	MD	1441:1442	arg1	simulations					1444:1454	all-atom explicit solvent MD simulations	1415:1454	all-atom explicit solvent MD simulations	1415:1454	CVLS also deduced the preferred composition of the high specificity hexasaccharides, which were further assessed in all-atom explicit solvent MD simulations.
34299163	4	87	theme	combinatorial	683:695	arg1	manner					697:702	a combinatorial manner	681:702	a combinatorial manner	681:702	All possible CS oligosaccharides were generated in a combinatorial manner to give 24 di- (CS02), 192 tetra- (CS04), and 1536 hexa- (CS06) saccharides.
34299163	2	88	theme	human	341:345	arg1	TGF-β2					352:357	preterm human milk TGF-β2	333:357	preterm human milk TGF-β2	333:357	In a recent study, we found that preterm human milk TGF-β2 is sequestered by chondroitin sulfate (CS) in its proteoglycan form.
34299163	0	89	theme	Screening	30:38	arg1	Study					40:44	Combinatorial Virtual Library Screening Study	0:44	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.	0:105	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.
34299163	13	90	theme	CS	2073:2074	arg1	biopolymers					2076:2086	common natural CS biopolymers	2058:2086	common natural CS biopolymers	2058:2086	Finally, the study led to the identification of unique CS sequences that are predicted to selectively recognize TGF-β2 and may out-compete common natural CS biopolymers.
34299163	6	91	theme	sulfation	1120:1128	arg1	level					1111:1115	level	1111:1115	level of sulfation	1111:1128	CVLS predicted that both the chain length and level of sulfation are critical for the high affinity and high specificity recognition of TGF-β2.
34299163	6	91	theme	sulfation	1120:1128	arg1	length					1100:1105	the chain length	1090:1105	the chain length	1090:1105	CVLS predicted that both the chain length and level of sulfation are critical for the high affinity and high specificity recognition of TGF-β2.
34299163	6	91	theme	sulfation	1120:1128	arg1	critical					1134:1141	critical	1134:1141	critical	1134:1141	CVLS predicted that both the chain length and level of sulfation are critical for the high affinity and high specificity recognition of TGF-β2.
34299163	3	92	theme	dynamics	603:610	arg1	simulations					617:627	molecular dynamics (MD) simulations	593:627	molecular dynamics (MD) simulations	593:627	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	2	93	theme	chondroitin	377:387	arg1	CS					398:399	CS	398:399	CS	398:399	In a recent study, we found that preterm human milk TGF-β2 is sequestered by chondroitin sulfate (CS) in its proteoglycan form.
34299163	2	93	theme	chondroitin	377:387	arg1	sulfate					389:395	chondroitin sulfate	377:395	chondroitin sulfate (CS)	377:400	In a recent study, we found that preterm human milk TGF-β2 is sequestered by chondroitin sulfate (CS) in its proteoglycan form.
34299163	1	94	theme	interaction	271:281	arg1	nature					256:261	the nature	252:261	the nature of this interaction	252:281	Transforming growth factor-beta (TGF-β), a member of the TGF-β cytokine superfamily, is known to bind to sulfated glycosaminoglycans (GAGs), but the nature of this interaction remains unclear.
34299163	0	95	theme	Growth	62:67	arg1	Sulfate					91:97	Transforming Growth Factor-β2-Chondroitin Sulfate	49:97	Transforming Growth Factor-β2-Chondroitin Sulfate System	49:104	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System.
34299163	5	96	theme	in	1042:1043	arg1	specificity					1052:1062	in silico specificity	1042:1062	in silico specificity	1042:1062	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	3	97	theme	molecular	446:454	arg1	basis					456:460	the molecular basis	442:460	the molecular basis of the TGF-β2-CS interaction	442:489	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	13	98	theme	common	2058:2063	arg1	biopolymers					2076:2086	common natural CS biopolymers	2058:2086	common natural CS biopolymers	2058:2086	Finally, the study led to the identification of unique CS sequences that are predicted to selectively recognize TGF-β2 and may out-compete common natural CS biopolymers.
34299163	9	99	theme	binding	1501:1507	arg1	sites					1492:1496	both sites	1487:1496	both sites of binding	1487:1507	The MD results confirmed that both sites of binding form stable GAG-protein complexes.
34299163	9	99	theme	binding	1501:1507	arg1	binding					1501:1507	binding	1501:1507	binding	1501:1507	The MD results confirmed that both sites of binding form stable GAG-protein complexes.
34299163	10	100	theme	CS	1584:1585	arg1	chains					1587:1592	the highly selective CS chains	1563:1592	the highly selective CS chains	1563:1592	More specifically, the highly selective CS chains were found to engage the TGF-β2 monomer with high affinity.
34299163	9	101	theme	stable	1514:1519	arg1	complexes					1533:1541	stable GAG-protein complexes	1514:1541	stable GAG-protein complexes	1514:1541	The MD results confirmed that both sites of binding form stable GAG-protein complexes.
34299163	3	102	with	approach	569:576	arg1	simulations					617:627	molecular dynamics (MD) simulations	593:627	molecular dynamics (MD) simulations	593:627	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
34299163	5	103	dep	best	967:970	arg1	poses					978:982	poses	978:982	poses	978:982	This library of 1752 CS oligosaccharides was first screened against TGF-β2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.
34299163	3	104	theme	TGF-β2-CS	469:477	arg1	interaction					479:489	the TGF-β2-CS interaction	465:489	the TGF-β2-CS interaction	465:489	To understand the molecular basis of the TGF-β2-CS interaction, we utilized the computational combinatorial virtual library screening (CVLS) approach in tandem with molecular dynamics (MD) simulations.
32611364	9	0	from	FLAs	1299:1302	arg1	benthamiana					1310:1320	N. benthamiana	1307:1320	N. benthamiana	1307:1320	CONCLUSIONS This study systematically identified FLAs in N. benthamiana, and indicates their potential roles in response to biotic stress.
32611364	9	1	from	roles	1353:1357	arg1	response					1362:1369	response	1362:1369	response to biotic stress	1362:1386	CONCLUSIONS This study systematically identified FLAs in N. benthamiana, and indicates their potential roles in response to biotic stress.
32611364	2	2	theme	plant	376:380	arg1	growth					382:387	plant growth	376:387	plant growth	376:387	Fasciclin-like arabinogalactan proteins (FLAs), a subclass of arabinogalactan proteins (AGPs), participate in mediating plant growth, development and response to abiotic stress.
32611364	7	3	theme	polymerase	869:878	arg1	reaction					886:893	Quantitative real time polymerase chain reaction	846:893	Quantitative real time polymerase chain reaction (RT-qPCR) results	846:911	Quantitative real time polymerase chain reaction (RT-qPCR) results showed that selected NbFLAs were differentially expressed in different tissues.
32611364	7	3	theme	polymerase	869:878	arg1	RT-qPCR					896:902	RT-qPCR	896:902	RT-qPCR	896:902	Quantitative real time polymerase chain reaction (RT-qPCR) results showed that selected NbFLAs were differentially expressed in different tissues.
32611364	10	4	theme	further	1434:1440	arg1	studies					1442:1448	further studies	1434:1448	further studies of their role in plant immunity in N. benthamiana	1434:1498	The identification of NbFLAs will facilitate further studies of their role in plant immunity in N. benthamiana.
32611364	5	5	theme	gene	648:651	arg1	structure					653:661	their gene structure	642:661	their gene structure	642:661	NbFLAs could be divided into four subclasses, and their gene structure and motif composition were conserved in each subclass.
32611364	10	6	theme	NbFLAs	1411:1416	arg1	identification					1393:1406	The identification	1389:1406	The identification of NbFLAs	1389:1416	The identification of NbFLAs will facilitate further studies of their role in plant immunity in N. benthamiana.
32611364	7	7	theme	Quantitative	846:857	arg1	reaction					886:893	Quantitative real time polymerase chain reaction	846:893	Quantitative real time polymerase chain reaction (RT-qPCR) results	846:911	Quantitative real time polymerase chain reaction (RT-qPCR) results showed that selected NbFLAs were differentially expressed in different tissues.
32611364	7	7	theme	Quantitative	846:857	arg1	RT-qPCR					896:902	RT-qPCR	896:902	RT-qPCR	896:902	Quantitative real time polymerase chain reaction (RT-qPCR) results showed that selected NbFLAs were differentially expressed in different tissues.
32611364	4	8	theme	genome-wide	573:583	arg1	study					585:589	a genome-wide study	571:589	a genome-wide study	571:589	RESULTS 38 NbFLAs were identified from a genome-wide study.
32611364	10	9	from	studies	1442:1448	arg1	immunity					1473:1480	plant immunity	1467:1480	plant immunity	1467:1480	The identification of NbFLAs will facilitate further studies of their role in plant immunity in N. benthamiana.
32611364	10	9	from	studies	1442:1448	arg1	benthamiana					1488:1498	N. benthamiana	1485:1498	N. benthamiana	1485:1498	The identification of NbFLAs will facilitate further studies of their role in plant immunity in N. benthamiana.
32611364	7	10	theme	real	859:862	arg1	reaction					886:893	Quantitative real time polymerase chain reaction	846:893	Quantitative real time polymerase chain reaction (RT-qPCR) results	846:911	Quantitative real time polymerase chain reaction (RT-qPCR) results showed that selected NbFLAs were differentially expressed in different tissues.
32611364	7	10	theme	real	859:862	arg1	RT-qPCR					896:902	RT-qPCR	896:902	RT-qPCR	896:902	Quantitative real time polymerase chain reaction (RT-qPCR) results showed that selected NbFLAs were differentially expressed in different tissues.
32611364	8	11	theme	Pseudomonas	1128:1138	arg1	Pst					1174:1176	Pst DC3000	1174:1183	Pst DC3000	1174:1183	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	8	11	theme	Pseudomonas	1128:1138	arg1	DC3000					1166:1171	Pseudomonas syringae pv tomato strain DC3000	1128:1171	Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000)	1128:1184	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	8	12	dep	Pseudomonas	1128:1138	arg1	syringae					1140:1147	syringae	1140:1147	syringae	1140:1147	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	7	13	theme	selected	925:932	arg1	NbFLAs					934:939	selected NbFLAs	925:939	selected NbFLAs	925:939	Quantitative real time polymerase chain reaction (RT-qPCR) results showed that selected NbFLAs were differentially expressed in different tissues.
32611364	3	14	theme	plant	503:507	arg1	pathogens					509:517	plant pathogens	503:517	plant pathogens	503:517	However, the members of FLAs in N. benthamiana and their response to plant pathogens are unknown.
32611364	8	15	theme	tomato	1152:1157	arg1	Pst					1174:1176	Pst DC3000	1174:1183	Pst DC3000	1174:1183	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	8	15	theme	tomato	1152:1157	arg1	DC3000					1166:1171	Pseudomonas syringae pv tomato strain DC3000	1128:1171	Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000)	1128:1184	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	9	16	theme	biotic	1374:1379	arg1	stress					1381:1386	biotic stress	1374:1386	biotic stress	1374:1386	CONCLUSIONS This study systematically identified FLAs in N. benthamiana, and indicates their potential roles in response to biotic stress.
32611364	10	17	theme	role	1459:1462	arg1	studies					1442:1448	further studies	1434:1448	further studies of their role in plant immunity in N. benthamiana	1434:1498	The identification of NbFLAs will facilitate further studies of their role in plant immunity in N. benthamiana.
32611364	8	18	theme	pv	1149:1150	arg1	Pst					1174:1176	Pst DC3000	1174:1183	Pst DC3000	1174:1183	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	8	18	theme	pv	1149:1150	arg1	DC3000					1166:1171	Pseudomonas syringae pv tomato strain DC3000	1128:1171	Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000)	1128:1184	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	10	19	from	benthamiana	1488:1498	arg1	studies					1442:1448	further studies	1434:1448	further studies of their role in plant immunity in N. benthamiana	1434:1498	The identification of NbFLAs will facilitate further studies of their role in plant immunity in N. benthamiana.
32611364	8	20	theme	strain	1159:1164	arg1	Pst					1174:1176	Pst DC3000	1174:1183	Pst DC3000	1174:1183	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	8	20	theme	strain	1159:1164	arg1	DC3000					1166:1171	Pseudomonas syringae pv tomato strain DC3000	1128:1171	Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000)	1128:1184	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	8	21	theme	possible	1198:1205	arg1	roles					1207:1211	possible roles	1198:1211	possible roles in response to pathogenic infection	1198:1247	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	0	22	theme	arabinogalactan	15:29	arg1	family					36:41	Fasciclin-like arabinogalactan gene family	0:41	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.	0:151	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.
32611364	9	23	theme	N.	1307:1308	arg1	benthamiana					1310:1320	N. benthamiana	1307:1320	N. benthamiana	1307:1320	CONCLUSIONS This study systematically identified FLAs in N. benthamiana, and indicates their potential roles in response to biotic stress.
32611364	0	24	theme	Fasciclin-like	0:13	arg1	family					36:41	Fasciclin-like arabinogalactan gene family	0:41	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.	0:151	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.
32611364	3	25	from	response	491:498	arg1	benthamiana					469:479	N. benthamiana	466:479	N. benthamiana	466:479	However, the members of FLAs in N. benthamiana and their response to plant pathogens are unknown.
32611364	1	26	theme	model	206:210	arg1	BACKGROUND					153:162	BACKGROUND	153:162	BACKGROUND Nicotiana benthamiana	153:184	BACKGROUND Nicotiana benthamiana is widely used as a model plant to study plant-pathogen interactions.
32611364	1	26	theme	model	206:210	arg1	plant					212:216	a model plant	204:216	a model plant to study plant-pathogen interactions	204:253	BACKGROUND Nicotiana benthamiana is widely used as a model plant to study plant-pathogen interactions.
32611364	8	27	theme	mosaic	1083:1088	arg1	virus					1090:1094	turnip mosaic virus	1076:1094	turnip mosaic virus (TuMV)	1076:1101	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	8	27	theme	mosaic	1083:1088	arg1	TuMV					1097:1100	TuMV	1097:1100	TuMV	1097:1100	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	2	28	theme	proteins	334:341	arg1	subclass					306:313	a subclass	304:313	a subclass of arabinogalactan proteins (AGPs)	304:348	Fasciclin-like arabinogalactan proteins (FLAs), a subclass of arabinogalactan proteins (AGPs), participate in mediating plant growth, development and response to abiotic stress.
32611364	2	28	theme	proteins	334:341	arg1	proteins					287:294	Fasciclin-like arabinogalactan proteins	256:294	Fasciclin-like arabinogalactan proteins (FLAs)	256:301	Fasciclin-like arabinogalactan proteins (FLAs), a subclass of arabinogalactan proteins (AGPs), participate in mediating plant growth, development and response to abiotic stress.
32611364	3	29	theme	N.	466:467	arg1	benthamiana					469:479	N. benthamiana	466:479	N. benthamiana	466:479	However, the members of FLAs in N. benthamiana and their response to plant pathogens are unknown.
32611364	0	30	theme	gene	31:34	arg1	family					36:41	Fasciclin-like arabinogalactan gene family	0:41	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.	0:151	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.
32611364	9	31	dep	CONCLUSIONS	1250:1260	arg1	indicates					1327:1335	indicates	1327:1335	indicates their potential roles in response to biotic stress	1327:1386	CONCLUSIONS This study systematically identified FLAs in N. benthamiana, and indicates their potential roles in response to biotic stress.
32611364	9	31	dep	CONCLUSIONS	1250:1260	arg1	identified					1288:1297	identified	1288:1297	identified FLAs in N. benthamiana	1288:1320	CONCLUSIONS This study systematically identified FLAs in N. benthamiana, and indicates their potential roles in response to biotic stress.
32611364	8	32	theme	turnip	1076:1081	arg1	virus					1090:1094	turnip mosaic virus	1076:1094	turnip mosaic virus (TuMV)	1076:1101	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	8	32	theme	turnip	1076:1081	arg1	TuMV					1097:1100	TuMV	1097:1100	TuMV	1097:1100	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	0	33	from	classification	97:110	arg1	response					130:137	response	130:137	response to pathogens	130:150	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.
32611364	2	34	theme	arabinogalactan	318:332	arg1	proteins					334:341	arabinogalactan proteins	318:341	arabinogalactan proteins (AGPs)	318:348	Fasciclin-like arabinogalactan proteins (FLAs), a subclass of arabinogalactan proteins (AGPs), participate in mediating plant growth, development and response to abiotic stress.
32611364	2	34	theme	arabinogalactan	318:332	arg1	AGPs					344:347	AGPs	344:347	AGPs	344:347	Fasciclin-like arabinogalactan proteins (FLAs), a subclass of arabinogalactan proteins (AGPs), participate in mediating plant growth, development and response to abiotic stress.
32611364	0	35	theme	Nicotiana	46:54	arg1	benthamiana					56:66	Nicotiana benthamiana	46:66	Nicotiana benthamiana	46:66	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.
32611364	10	36	theme	plant	1467:1471	arg1	immunity					1473:1480	plant immunity	1467:1480	plant immunity	1467:1480	The identification of NbFLAs will facilitate further studies of their role in plant immunity in N. benthamiana.
32611364	2	37	theme	arabinogalactan	271:285	arg1	subclass					306:313	a subclass	304:313	a subclass of arabinogalactan proteins (AGPs)	304:348	Fasciclin-like arabinogalactan proteins (FLAs), a subclass of arabinogalactan proteins (AGPs), participate in mediating plant growth, development and response to abiotic stress.
32611364	2	37	theme	arabinogalactan	271:285	arg1	FLAs					297:300	FLAs	297:300	FLAs	297:300	Fasciclin-like arabinogalactan proteins (FLAs), a subclass of arabinogalactan proteins (AGPs), participate in mediating plant growth, development and response to abiotic stress.
32611364	2	37	theme	arabinogalactan	271:285	arg1	proteins					287:294	Fasciclin-like arabinogalactan proteins	256:294	Fasciclin-like arabinogalactan proteins (FLAs)	256:301	Fasciclin-like arabinogalactan proteins (FLAs), a subclass of arabinogalactan proteins (AGPs), participate in mediating plant growth, development and response to abiotic stress.
32611364	3	38	theme	FLAs	458:461	arg1	members					447:453	the members	443:453	the members of FLAs in N. benthamiana and their response to plant pathogens	443:517	However, the members of FLAs in N. benthamiana and their response to plant pathogens are unknown.
32611364	3	38	theme	FLAs	458:461	arg1	unknown					523:529	unknown	523:529	unknown	523:529	However, the members of FLAs in N. benthamiana and their response to plant pathogens are unknown.
32611364	4	39	theme	RESULTS	532:538	arg1	NbFLAs					543:548	RESULTS 38 NbFLAs	532:548	RESULTS 38 NbFLAs	532:548	RESULTS 38 NbFLAs were identified from a genome-wide study.
32611364	0	40	from	identification	81:94	arg1	response					130:137	response	130:137	response to pathogens	130:150	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.
32611364	2	41	theme	Fasciclin-like	256:269	arg1	subclass					306:313	a subclass	304:313	a subclass of arabinogalactan proteins (AGPs)	304:348	Fasciclin-like arabinogalactan proteins (FLAs), a subclass of arabinogalactan proteins (AGPs), participate in mediating plant growth, development and response to abiotic stress.
32611364	2	41	theme	Fasciclin-like	256:269	arg1	FLAs					297:300	FLAs	297:300	FLAs	297:300	Fasciclin-like arabinogalactan proteins (FLAs), a subclass of arabinogalactan proteins (AGPs), participate in mediating plant growth, development and response to abiotic stress.
32611364	2	41	theme	Fasciclin-like	256:269	arg1	proteins					287:294	Fasciclin-like arabinogalactan proteins	256:294	Fasciclin-like arabinogalactan proteins (FLAs)	256:301	Fasciclin-like arabinogalactan proteins (FLAs), a subclass of arabinogalactan proteins (AGPs), participate in mediating plant growth, development and response to abiotic stress.
32611364	3	42	from	FLAs	458:461	arg1	benthamiana					469:479	N. benthamiana	466:479	N. benthamiana	466:479	However, the members of FLAs in N. benthamiana and their response to plant pathogens are unknown.
32611364	1	43	theme	plant-pathogen	227:240	arg1	interactions					242:253	plant-pathogen interactions	227:253	plant-pathogen interactions	227:253	BACKGROUND Nicotiana benthamiana is widely used as a model plant to study plant-pathogen interactions.
32611364	9	44	theme	potential	1343:1351	arg1	roles					1353:1357	their potential roles	1337:1357	their potential roles in response to biotic stress	1337:1386	CONCLUSIONS This study systematically identified FLAs in N. benthamiana, and indicates their potential roles in response to biotic stress.
32611364	5	45	theme	motif	667:671	arg1	composition					673:683	motif composition	667:683	motif composition	667:683	NbFLAs could be divided into four subclasses, and their gene structure and motif composition were conserved in each subclass.
32611364	6	46	theme	factors	827:833	arg1	targets					802:808	the targets	798:808	the targets of transcription factors like C2H2	798:843	NbFLAs may be regulated by cis-acting elements such as STRE and MBS, and may be the targets of transcription factors like C2H2.
32611364	3	47	theme	response	491:498	arg1	members					447:453	the members	443:453	the members of FLAs in N. benthamiana and their response to plant pathogens	443:517	However, the members of FLAs in N. benthamiana and their response to plant pathogens are unknown.
32611364	3	47	theme	response	491:498	arg1	unknown					523:529	unknown	523:529	unknown	523:529	However, the members of FLAs in N. benthamiana and their response to plant pathogens are unknown.
32611364	10	48	from	role	1459:1462	arg1	immunity					1473:1480	plant immunity	1467:1480	plant immunity	1467:1480	The identification of NbFLAs will facilitate further studies of their role in plant immunity in N. benthamiana.
32611364	10	48	from	role	1459:1462	arg1	benthamiana					1488:1498	N. benthamiana	1485:1498	N. benthamiana	1485:1498	The identification of NbFLAs will facilitate further studies of their role in plant immunity in N. benthamiana.
32611364	6	49	theme	transcription	813:825	arg1	factors					827:833	transcription factors	813:833	transcription factors like C2H2	813:843	NbFLAs may be regulated by cis-acting elements such as STRE and MBS, and may be the targets of transcription factors like C2H2.
32611364	6	50	theme	cis-acting	745:754	arg1	MBS					782:784	MBS	782:784	MBS	782:784	NbFLAs may be regulated by cis-acting elements such as STRE and MBS, and may be the targets of transcription factors like C2H2.
32611364	6	50	theme	cis-acting	745:754	arg1	elements					756:763	cis-acting elements	745:763	cis-acting elements such as STRE and MBS	745:784	NbFLAs may be regulated by cis-acting elements such as STRE and MBS, and may be the targets of transcription factors like C2H2.
32611364	6	50	theme	cis-acting	745:754	arg1	STRE					773:776	STRE	773:776	STRE	773:776	NbFLAs may be regulated by cis-acting elements such as STRE and MBS, and may be the targets of transcription factors like C2H2.
32611364	0	51	dep	family	36:41	arg1	expression					116:125	expression	116:125	expression	116:125	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.
32611364	0	51	dep	family	36:41	arg1	classification					97:110	classification	97:110	classification	97:110	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.
32611364	0	51	dep	family	36:41	arg1	identification					81:94	genome-wide identification	69:94	genome-wide identification	69:94	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.
32611364	3	52	from	benthamiana	469:479	arg1	members					447:453	the members	443:453	the members of FLAs in N. benthamiana and their response to plant pathogens	443:517	However, the members of FLAs in N. benthamiana and their response to plant pathogens are unknown.
32611364	3	52	from	benthamiana	469:479	arg1	unknown					523:529	unknown	523:529	unknown	523:529	However, the members of FLAs in N. benthamiana and their response to plant pathogens are unknown.
32611364	8	53	from	roles	1207:1211	arg1	response					1216:1223	response	1216:1223	response to pathogenic infection	1216:1247	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	10	54	theme	N.	1485:1486	arg1	benthamiana					1488:1498	N. benthamiana	1485:1498	N. benthamiana	1485:1498	The identification of NbFLAs will facilitate further studies of their role in plant immunity in N. benthamiana.
32611364	0	55	from	expression	116:125	arg1	response					130:137	response	130:137	response to pathogens	130:150	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.
32611364	7	56	theme	different	974:982	arg1	tissues					984:990	different tissues	974:990	different tissues	974:990	Quantitative real time polymerase chain reaction (RT-qPCR) results showed that selected NbFLAs were differentially expressed in different tissues.
32611364	7	57	theme	chain	880:884	arg1	reaction					886:893	Quantitative real time polymerase chain reaction	846:893	Quantitative real time polymerase chain reaction (RT-qPCR) results	846:911	Quantitative real time polymerase chain reaction (RT-qPCR) results showed that selected NbFLAs were differentially expressed in different tissues.
32611364	7	57	theme	chain	880:884	arg1	RT-qPCR					896:902	RT-qPCR	896:902	RT-qPCR	896:902	Quantitative real time polymerase chain reaction (RT-qPCR) results showed that selected NbFLAs were differentially expressed in different tissues.
32611364	2	58	theme	abiotic	418:424	arg1	stress					426:431	abiotic stress	418:431	abiotic stress	418:431	Fasciclin-like arabinogalactan proteins (FLAs), a subclass of arabinogalactan proteins (AGPs), participate in mediating plant growth, development and response to abiotic stress.
32611364	1	59	dep	plant	212:216	arg1	study					221:225	study	221:225	to study plant-pathogen interactions	218:253	BACKGROUND Nicotiana benthamiana is widely used as a model plant to study plant-pathogen interactions.
32611364	8	60	theme	pathogenic	1228:1237	arg1	infection					1239:1247	pathogenic infection	1228:1247	pathogenic infection	1228:1247	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	7	61	theme	reaction	886:893	arg1	results					905:911	Quantitative real time polymerase chain reaction (RT-qPCR) results	846:911	Quantitative real time polymerase chain reaction (RT-qPCR) results	846:911	Quantitative real time polymerase chain reaction (RT-qPCR) results showed that selected NbFLAs were differentially expressed in different tissues.
32611364	8	62	theme	selected	1004:1011	arg1	NbFLAs					1013:1018	the selected NbFLAs	1000:1018	the selected NbFLAs	1000:1018	All of the selected NbFLAs were significantly downregulated following infection by turnip mosaic virus (TuMV) and most of them also by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000), suggesting possible roles in response to pathogenic infection.
32611364	0	63	theme	genome-wide	69:79	arg1	identification					81:94	genome-wide identification	69:94	genome-wide identification	69:94	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.
32611364	0	64	from	family	36:41	arg1	benthamiana					56:66	Nicotiana benthamiana	46:66	Nicotiana benthamiana	46:66	Fasciclin-like arabinogalactan gene family in Nicotiana benthamiana: genome-wide identification, classification and expression in response to pathogens.
32611364	1	65	used	used	196:199	arg2	BACKGROUND					153:162	BACKGROUND	153:162	BACKGROUND Nicotiana benthamiana	153:184	BACKGROUND Nicotiana benthamiana is widely used as a model plant to study plant-pathogen interactions.
32611364	1	65	used	used	196:199	arg2	plant					212:216	a model plant	204:216	a model plant to study plant-pathogen interactions	204:253	BACKGROUND Nicotiana benthamiana is widely used as a model plant to study plant-pathogen interactions.
32611364	3	66	from	members	447:453	arg1	benthamiana					469:479	N. benthamiana	466:479	N. benthamiana	466:479	However, the members of FLAs in N. benthamiana and their response to plant pathogens are unknown.
32611364	7	67	theme	time	864:867	arg1	reaction					886:893	Quantitative real time polymerase chain reaction	846:893	Quantitative real time polymerase chain reaction (RT-qPCR) results	846:911	Quantitative real time polymerase chain reaction (RT-qPCR) results showed that selected NbFLAs were differentially expressed in different tissues.
32611364	7	67	theme	time	864:867	arg1	RT-qPCR					896:902	RT-qPCR	896:902	RT-qPCR	896:902	Quantitative real time polymerase chain reaction (RT-qPCR) results showed that selected NbFLAs were differentially expressed in different tissues.
32611364	10	68	from	immunity	1473:1480	arg1	studies					1442:1448	further studies	1434:1448	further studies of their role in plant immunity in N. benthamiana	1434:1498	The identification of NbFLAs will facilitate further studies of their role in plant immunity in N. benthamiana.
34600659	8	0	theme	reduced	1467:1473	arg1	levels					1484:1489	reduced ammonium levels	1467:1489	reduced ammonium levels	1467:1489	Changes in microbial metabolism were associated with increased short-chain fatty acid concentrations and reduced ammonium levels, particularly in the prebiotic and synbiotic treatments.
34600659	8	1	theme	increased	1415:1423	arg1	concentrations					1448:1461	increased short-chain fatty acid concentrations	1415:1461	increased short-chain fatty acid concentrations	1415:1461	Changes in microbial metabolism were associated with increased short-chain fatty acid concentrations and reduced ammonium levels, particularly in the prebiotic and synbiotic treatments.
34600659	0	2	dep	in	98:99	arg1	vitro					101:105	vitro	101:105	vitro	101:105	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model.
34600659	4	3	from	impact	658:663	arg1	composition					785:795	gut microbiota composition	770:795	gut microbiota composition	770:795	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	4	3	from	impact	658:663	arg1	metabolism					801:810	metabolism	801:810	metabolism	801:810	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	0	4	theme	gut	53:55	arg1	microbiota					57:66	the gut microbiota	49:66	the gut microbiota of autistic children	49:87	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model.
34600659	2	5	theme	potential	306:314	arg1	strategy					330:337	a potential and promising strategy	304:337	a potential and promising strategy for regulating the gut microbiota and improving ASD-related symptoms	304:406	The administration of probiotics, prebiotics, and synbiotics is emerging as a potential and promising strategy for regulating the gut microbiota and improving ASD-related symptoms.
34600659	6	6	with	children	1108:1115	arg1	ASD					1122:1124	ASD	1122:1124	ASD	1122:1124	The probiotic, prebiotic, and synbiotic treatments resulted in a positive modulation of the gut microbiota and metabolic activity of children with ASD.
34600659	0	7	theme	autistic	71:78	arg1	children					80:87	autistic children	71:87	autistic children	71:87	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model.
34600659	0	8	from	Effect	0:5	arg1	microbiota					57:66	the gut microbiota	49:66	the gut microbiota of autistic children	49:87	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model.
34600659	1	9	from	Imbalances	129:138	arg1	composition					158:168	gut microbiota composition	143:168	gut microbiota composition	143:168	Imbalances in gut microbiota composition occur in individuals with autism spectrum disorder (ASD).
34600659	7	10	theme	Lachnoclostridium	1343:1359	arg1	abundance					1330:1338	the relative abundance	1317:1338	the relative abundance of Lachnoclostridium	1317:1359	More specifically, the probiotic treatment increased the relative abundance of Lactobacillus, while the prebiotic treatment increased the relative abundance of Bifidobacterium and decreased the relative abundance of Lachnoclostridium.
34600659	3	11	dep	L.	483:484	arg1	B.					516:517	B.	516:517	B.	516:517	We first investigated the survival of the probiotics Limosilactobacillus (L.) reuteri and Bifidobacterium (B.) longum alone, mixed and combined with a galacto-oligosaccharide (GOS) under simulated gastrointestinal conditions.
34600659	3	11	dep	L.	483:484	arg1	Bifidobacterium					499:513	Bifidobacterium	499:513	Bifidobacterium (B.)	499:518	We first investigated the survival of the probiotics Limosilactobacillus (L.) reuteri and Bifidobacterium (B.) longum alone, mixed and combined with a galacto-oligosaccharide (GOS) under simulated gastrointestinal conditions.
34600659	3	11	dep	L.	483:484	arg1	reuteri					487:493	reuteri	487:493	reuteri	487:493	We first investigated the survival of the probiotics Limosilactobacillus (L.) reuteri and Bifidobacterium (B.) longum alone, mixed and combined with a galacto-oligosaccharide (GOS) under simulated gastrointestinal conditions.
34600659	3	12	dep	probiotics	451:460	arg1	combined					544:551	combined	544:551	combined with a galacto-oligosaccharide (GOS) under simulated gastrointestinal conditions	544:632	We first investigated the survival of the probiotics Limosilactobacillus (L.) reuteri and Bifidobacterium (B.) longum alone, mixed and combined with a galacto-oligosaccharide (GOS) under simulated gastrointestinal conditions.
34600659	3	12	dep	probiotics	451:460	arg1	L.					483:484	L.	483:484	L.	483:484	We first investigated the survival of the probiotics Limosilactobacillus (L.) reuteri and Bifidobacterium (B.) longum alone, mixed and combined with a galacto-oligosaccharide (GOS) under simulated gastrointestinal conditions.
34600659	3	12	dep	probiotics	451:460	arg1	mixed					534:538	mixed	534:538	mixed	534:538	We first investigated the survival of the probiotics Limosilactobacillus (L.) reuteri and Bifidobacterium (B.) longum alone, mixed and combined with a galacto-oligosaccharide (GOS) under simulated gastrointestinal conditions.
34600659	2	13	theme	probiotics	250:259	arg1	administration					232:245	The administration	228:245	The administration of probiotics, prebiotics, and synbiotics	228:287	The administration of probiotics, prebiotics, and synbiotics is emerging as a potential and promising strategy for regulating the gut microbiota and improving ASD-related symptoms.
34600659	8	14	from	Changes	1362:1368	arg1	metabolism					1383:1392	microbial metabolism	1373:1392	microbial metabolism	1373:1392	Changes in microbial metabolism were associated with increased short-chain fatty acid concentrations and reduced ammonium levels, particularly in the prebiotic and synbiotic treatments.
34600659	4	15	theme	microbiota	774:783	arg1	composition					785:795	gut microbiota composition	770:795	gut microbiota composition	770:795	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	6	16	theme	synbiotic	1005:1013	arg1	treatments					1015:1024	The probiotic, prebiotic, and synbiotic treatments	975:1024	The probiotic, prebiotic, and synbiotic treatments	975:1024	The probiotic, prebiotic, and synbiotic treatments resulted in a positive modulation of the gut microbiota and metabolic activity of children with ASD.
34600659	6	17	theme	metabolic	1086:1094	arg1	activity					1096:1103	metabolic activity	1086:1103	metabolic activity of children with ASD	1086:1124	The probiotic, prebiotic, and synbiotic treatments resulted in a positive modulation of the gut microbiota and metabolic activity of children with ASD.
34600659	2	18	theme	gut	358:360	arg1	microbiota					362:371	the gut microbiota	354:371	the gut microbiota	354:371	The administration of probiotics, prebiotics, and synbiotics is emerging as a potential and promising strategy for regulating the gut microbiota and improving ASD-related symptoms.
34600659	0	19	theme	children	80:87	arg1	microbiota					57:66	the gut microbiota	49:66	the gut microbiota of autistic children	49:87	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model.
34600659	8	20	theme	prebiotic	1512:1520	arg1	treatments					1536:1545	the prebiotic and synbiotic treatments	1508:1545	the prebiotic and synbiotic treatments	1508:1545	Changes in microbial metabolism were associated with increased short-chain fatty acid concentrations and reduced ammonium levels, particularly in the prebiotic and synbiotic treatments.
34600659	4	21	theme	gut	770:772	arg1	composition					785:795	gut microbiota composition	770:795	gut microbiota composition	770:795	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	5	22	theme	reuteri	902:908	arg1	combination					884:894	The combination	880:894	The combination of L. reuteri, B. longum, and GOS	880:928	The combination of L. reuteri, B. longum, and GOS showed elevated gastrointestinal resistance.
34600659	8	23	theme	fatty	1437:1441	arg1	acid					1443:1446	short-chain fatty acid	1425:1446	increased short-chain fatty acid concentrations	1415:1461	Changes in microbial metabolism were associated with increased short-chain fatty acid concentrations and reduced ammonium levels, particularly in the prebiotic and synbiotic treatments.
34600659	1	24	theme	gut	143:145	arg1	composition					158:168	gut microbiota composition	143:168	gut microbiota composition	143:168	Imbalances in gut microbiota composition occur in individuals with autism spectrum disorder (ASD).
34600659	6	25	theme	microbiota	1071:1080	arg1	activity					1096:1103	metabolic activity	1086:1103	metabolic activity of children with ASD	1086:1124	The probiotic, prebiotic, and synbiotic treatments resulted in a positive modulation of the gut microbiota and metabolic activity of children with ASD.
34600659	6	25	theme	microbiota	1071:1080	arg1	modulation					1049:1058	a positive modulation	1038:1058	a positive modulation of the gut microbiota	1038:1080	The probiotic, prebiotic, and synbiotic treatments resulted in a positive modulation of the gut microbiota and metabolic activity of children with ASD.
34600659	2	26	theme	synbiotics	278:287	arg1	administration					232:245	The administration	228:245	The administration of probiotics, prebiotics, and synbiotics	228:287	The administration of probiotics, prebiotics, and synbiotics is emerging as a potential and promising strategy for regulating the gut microbiota and improving ASD-related symptoms.
34600659	1	27	with	individuals	179:189	arg1	disorder					212:219	autism spectrum disorder	196:219	autism spectrum disorder (ASD)	196:225	Imbalances in gut microbiota composition occur in individuals with autism spectrum disorder (ASD).
34600659	1	27	with	individuals	179:189	arg1	ASD					222:224	ASD	222:224	ASD	222:224	Imbalances in gut microbiota composition occur in individuals with autism spectrum disorder (ASD).
34600659	1	28	theme	microbiota	147:156	arg1	composition					158:168	gut microbiota composition	143:168	gut microbiota composition	143:168	Imbalances in gut microbiota composition occur in individuals with autism spectrum disorder (ASD).
34600659	8	29	from	levels	1484:1489	arg1	treatments					1536:1545	the prebiotic and synbiotic treatments	1508:1545	the prebiotic and synbiotic treatments	1508:1545	Changes in microbial metabolism were associated with increased short-chain fatty acid concentrations and reduced ammonium levels, particularly in the prebiotic and synbiotic treatments.
34600659	8	30	theme	synbiotic	1526:1534	arg1	treatments					1536:1545	the prebiotic and synbiotic treatments	1508:1545	the prebiotic and synbiotic treatments	1508:1545	Changes in microbial metabolism were associated with increased short-chain fatty acid concentrations and reduced ammonium levels, particularly in the prebiotic and synbiotic treatments.
34600659	6	31	theme	gut	1067:1069	arg1	microbiota					1071:1080	the gut microbiota	1063:1080	the gut microbiota	1063:1080	The probiotic, prebiotic, and synbiotic treatments resulted in a positive modulation of the gut microbiota and metabolic activity of children with ASD.
34600659	6	32	theme	probiotic	979:987	arg1	treatments					1015:1024	The probiotic, prebiotic, and synbiotic treatments	975:1024	The probiotic, prebiotic, and synbiotic treatments	975:1024	The probiotic, prebiotic, and synbiotic treatments resulted in a positive modulation of the gut microbiota and metabolic activity of children with ASD.
34600659	6	33	theme	prebiotic	990:998	arg1	treatments					1015:1024	The probiotic, prebiotic, and synbiotic treatments	975:1024	The probiotic, prebiotic, and synbiotic treatments	975:1024	The probiotic, prebiotic, and synbiotic treatments resulted in a positive modulation of the gut microbiota and metabolic activity of children with ASD.
34600659	0	34	theme	in	98:99	arg1	model					122:126	an in vitro gut microbiome model	95:126	an in vitro gut microbiome model	95:126	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model.
34600659	3	35	dep	reuteri	487:493	arg1	longum					520:525	longum	520:525	longum	520:525	We first investigated the survival of the probiotics Limosilactobacillus (L.) reuteri and Bifidobacterium (B.) longum alone, mixed and combined with a galacto-oligosaccharide (GOS) under simulated gastrointestinal conditions.
34600659	2	36	theme	ASD-related	387:397	arg1	symptoms					399:406	ASD-related symptoms	387:406	ASD-related symptoms	387:406	The administration of probiotics, prebiotics, and synbiotics is emerging as a potential and promising strategy for regulating the gut microbiota and improving ASD-related symptoms.
34600659	0	37	theme	probiotic	10:18	arg1	Effect					0:5	Effect	0:5	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children	0:87	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model.
34600659	3	38	theme	gastrointestinal	606:621	arg1	conditions					623:632	simulated gastrointestinal conditions	596:632	simulated gastrointestinal conditions	596:632	We first investigated the survival of the probiotics Limosilactobacillus (L.) reuteri and Bifidobacterium (B.) longum alone, mixed and combined with a galacto-oligosaccharide (GOS) under simulated gastrointestinal conditions.
34600659	2	39	theme	prebiotics	262:271	arg1	administration					232:245	The administration	228:245	The administration of probiotics, prebiotics, and synbiotics	228:287	The administration of probiotics, prebiotics, and synbiotics is emerging as a potential and promising strategy for regulating the gut microbiota and improving ASD-related symptoms.
34600659	7	40	theme	prebiotic	1231:1239	arg1	treatment					1241:1249	the prebiotic treatment	1227:1249	the prebiotic treatment	1227:1249	More specifically, the probiotic treatment increased the relative abundance of Lactobacillus, while the prebiotic treatment increased the relative abundance of Bifidobacterium and decreased the relative abundance of Lachnoclostridium.
34600659	6	41	theme	positive	1040:1047	arg1	modulation					1049:1058	a positive modulation	1038:1058	a positive modulation of the gut microbiota	1038:1080	The probiotic, prebiotic, and synbiotic treatments resulted in a positive modulation of the gut microbiota and metabolic activity of children with ASD.
34600659	0	42	theme	gut	107:109	arg1	model					122:126	an in vitro gut microbiome model	95:126	an in vitro gut microbiome model	95:126	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model.
34600659	7	43	theme	relative	1321:1328	arg1	abundance					1330:1338	the relative abundance	1317:1338	the relative abundance of Lachnoclostridium	1317:1359	More specifically, the probiotic treatment increased the relative abundance of Lactobacillus, while the prebiotic treatment increased the relative abundance of Bifidobacterium and decreased the relative abundance of Lachnoclostridium.
34600659	0	44	theme	prebiotic	21:29	arg1	Effect					0:5	Effect	0:5	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children	0:87	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model.
34600659	8	45	theme	short-chain	1425:1435	arg1	acid					1443:1446	short-chain fatty acid	1425:1446	increased short-chain fatty acid concentrations	1415:1461	Changes in microbial metabolism were associated with increased short-chain fatty acid concentrations and reduced ammonium levels, particularly in the prebiotic and synbiotic treatments.
34600659	5	46	theme	GOS	926:928	arg1	combination					884:894	The combination	880:894	The combination of L. reuteri, B. longum, and GOS	880:928	The combination of L. reuteri, B. longum, and GOS showed elevated gastrointestinal resistance.
34600659	0	47	theme	synbiotic	36:44	arg1	Effect					0:5	Effect	0:5	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children	0:87	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model.
34600659	3	48	theme	simulated	596:604	arg1	conditions					623:632	simulated gastrointestinal conditions	596:632	simulated gastrointestinal conditions	596:632	We first investigated the survival of the probiotics Limosilactobacillus (L.) reuteri and Bifidobacterium (B.) longum alone, mixed and combined with a galacto-oligosaccharide (GOS) under simulated gastrointestinal conditions.
34600659	8	49	theme	acid	1443:1446	arg1	concentrations					1448:1461	increased short-chain fatty acid concentrations	1415:1461	increased short-chain fatty acid concentrations	1415:1461	Changes in microbial metabolism were associated with increased short-chain fatty acid concentrations and reduced ammonium levels, particularly in the prebiotic and synbiotic treatments.
34600659	0	50	theme	microbiome	111:120	arg1	model					122:126	an in vitro gut microbiome model	95:126	an in vitro gut microbiome model	95:126	Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model.
34600659	5	51	theme	gastrointestinal	946:961	arg1	resistance					963:972	elevated gastrointestinal resistance	937:972	elevated gastrointestinal resistance	937:972	The combination of L. reuteri, B. longum, and GOS showed elevated gastrointestinal resistance.
34600659	5	52	theme	elevated	937:944	arg1	resistance					963:972	elevated gastrointestinal resistance	937:972	elevated gastrointestinal resistance	937:972	The combination of L. reuteri, B. longum, and GOS showed elevated gastrointestinal resistance.
34600659	7	53	theme	relative	1265:1272	arg1	abundance					1274:1282	the relative abundance	1261:1282	the relative abundance of Bifidobacterium	1261:1301	More specifically, the probiotic treatment increased the relative abundance of Lactobacillus, while the prebiotic treatment increased the relative abundance of Bifidobacterium and decreased the relative abundance of Lachnoclostridium.
34600659	4	54	theme	probiotics	668:677	arg1	impact					658:663	the impact	654:663	the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD	654:831	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	8	55	theme	microbial	1373:1381	arg1	metabolism					1383:1392	microbial metabolism	1373:1392	microbial metabolism	1373:1392	Changes in microbial metabolism were associated with increased short-chain fatty acid concentrations and reduced ammonium levels, particularly in the prebiotic and synbiotic treatments.
34600659	4	56	theme	in	842:843	arg1	SHIME®					871:876	SHIME®	871:876	SHIME®	871:876	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	4	56	theme	in	842:843	arg1	model					864:868	an in vitro fermentation model	839:868	an in vitro fermentation model (SHIME®)	839:877	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	7	57	theme	Bifidobacterium	1287:1301	arg1	abundance					1274:1282	the relative abundance	1261:1282	the relative abundance of Bifidobacterium	1261:1301	More specifically, the probiotic treatment increased the relative abundance of Lactobacillus, while the prebiotic treatment increased the relative abundance of Bifidobacterium and decreased the relative abundance of Lachnoclostridium.
34600659	4	58	theme	synbiotic	726:734	arg1	impact					658:663	the impact	654:663	the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD	654:831	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	4	59	dep	reuteri + B.	683:694	arg1	longum					696:701	L. reuteri + B. longum	680:701	L. reuteri + B. longum	680:701	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	7	60	theme	relative	1184:1191	arg1	abundance					1193:1201	the relative abundance	1180:1201	the relative abundance of Lactobacillus	1180:1218	More specifically, the probiotic treatment increased the relative abundance of Lactobacillus, while the prebiotic treatment increased the relative abundance of Bifidobacterium and decreased the relative abundance of Lachnoclostridium.
34600659	4	61	theme	prebiotic	705:713	arg1	impact					658:663	the impact	654:663	the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD	654:831	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	1	62	theme	autism	196:201	arg1	disorder					212:219	autism spectrum disorder	196:219	autism spectrum disorder (ASD)	196:225	Imbalances in gut microbiota composition occur in individuals with autism spectrum disorder (ASD).
34600659	1	62	theme	autism	196:201	arg1	ASD					222:224	ASD	222:224	ASD	222:224	Imbalances in gut microbiota composition occur in individuals with autism spectrum disorder (ASD).
34600659	7	63	theme	Lactobacillus	1206:1218	arg1	abundance					1193:1201	the relative abundance	1180:1201	the relative abundance of Lactobacillus	1180:1218	More specifically, the probiotic treatment increased the relative abundance of Lactobacillus, while the prebiotic treatment increased the relative abundance of Bifidobacterium and decreased the relative abundance of Lachnoclostridium.
34600659	3	64	theme	probiotics	451:460	arg1	survival					435:442	the survival	431:442	the survival of the probiotics Limosilactobacillus (L.) reuteri and Bifidobacterium (B.) longum alone, mixed and combined with a galacto-oligosaccharide (GOS) under simulated gastrointestinal conditions	431:632	We first investigated the survival of the probiotics Limosilactobacillus (L.) reuteri and Bifidobacterium (B.) longum alone, mixed and combined with a galacto-oligosaccharide (GOS) under simulated gastrointestinal conditions.
34600659	4	65	theme	children	815:822	arg1	composition					785:795	gut microbiota composition	770:795	gut microbiota composition	770:795	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	4	65	theme	children	815:822	arg1	metabolism					801:810	metabolism	801:810	metabolism	801:810	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	1	66	theme	spectrum	203:210	arg1	disorder					212:219	autism spectrum disorder	196:219	autism spectrum disorder (ASD)	196:225	Imbalances in gut microbiota composition occur in individuals with autism spectrum disorder (ASD).
34600659	1	66	theme	spectrum	203:210	arg1	ASD					222:224	ASD	222:224	ASD	222:224	Imbalances in gut microbiota composition occur in individuals with autism spectrum disorder (ASD).
34600659	4	67	dep	in	842:843	arg1	vitro					845:849	vitro	845:849	vitro	845:849	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	4	68	theme	fermentation	851:862	arg1	SHIME®					871:876	SHIME®	871:876	SHIME®	871:876	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	4	68	theme	fermentation	851:862	arg1	model					864:868	an in vitro fermentation model	839:868	an in vitro fermentation model (SHIME®)	839:877	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	5	69	theme	longum	914:919	arg1	combination					884:894	The combination	880:894	The combination of L. reuteri, B. longum, and GOS	880:928	The combination of L. reuteri, B. longum, and GOS showed elevated gastrointestinal resistance.
34600659	4	70	with	children	815:822	arg1	ASD					829:831	ASD	829:831	ASD	829:831	Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®).
34600659	8	71	theme	ammonium	1475:1482	arg1	levels					1484:1489	reduced ammonium levels	1467:1489	reduced ammonium levels	1467:1489	Changes in microbial metabolism were associated with increased short-chain fatty acid concentrations and reduced ammonium levels, particularly in the prebiotic and synbiotic treatments.
34600659	6	72	theme	children	1108:1115	arg1	activity					1096:1103	metabolic activity	1086:1103	metabolic activity of children with ASD	1086:1124	The probiotic, prebiotic, and synbiotic treatments resulted in a positive modulation of the gut microbiota and metabolic activity of children with ASD.
34600659	6	72	theme	children	1108:1115	arg1	modulation					1049:1058	a positive modulation	1038:1058	a positive modulation of the gut microbiota	1038:1080	The probiotic, prebiotic, and synbiotic treatments resulted in a positive modulation of the gut microbiota and metabolic activity of children with ASD.
34600659	2	73	theme	promising	320:328	arg1	strategy					330:337	a potential and promising strategy	304:337	a potential and promising strategy for regulating the gut microbiota and improving ASD-related symptoms	304:406	The administration of probiotics, prebiotics, and synbiotics is emerging as a potential and promising strategy for regulating the gut microbiota and improving ASD-related symptoms.
34600659	7	74	theme	probiotic	1150:1158	arg1	treatment					1160:1168	the probiotic treatment	1146:1168	the probiotic treatment	1146:1168	More specifically, the probiotic treatment increased the relative abundance of Lactobacillus, while the prebiotic treatment increased the relative abundance of Bifidobacterium and decreased the relative abundance of Lachnoclostridium.
34600659	8	75	from	concentrations	1448:1461	arg1	treatments					1536:1545	the prebiotic and synbiotic treatments	1508:1545	the prebiotic and synbiotic treatments	1508:1545	Changes in microbial metabolism were associated with increased short-chain fatty acid concentrations and reduced ammonium levels, particularly in the prebiotic and synbiotic treatments.
34019919	6	0	theme	starch-based	1380:1391	arg1	films					1393:1397	starch-based films	1380:1397	starch-based films	1380:1397	In sum, Nano-ZnO and nano-SiO2 nanoparticles can be used as composite reinforcing agents for preparation of starch-based films through extrusion blowing.
34019919	5	1	theme	smooth	1155:1160	arg1	appearances					1181:1191	smooth, flat, and uniform appearances	1155:1191	smooth, flat, and uniform appearances	1155:1191	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	6	2	theme	Nano-ZnO	1280:1287	arg1	nanoparticles					1303:1315	Nano-ZnO and nano-SiO2 nanoparticles	1280:1315	Nano-ZnO and nano-SiO2 nanoparticles	1280:1315	In sum, Nano-ZnO and nano-SiO2 nanoparticles can be used as composite reinforcing agents for preparation of starch-based films through extrusion blowing.
34019919	6	2	theme	Nano-ZnO	1280:1287	arg1	agents					1354:1359	composite reinforcing agents	1332:1359	composite reinforcing agents for preparation of starch-based films through extrusion blowing	1332:1423	In sum, Nano-ZnO and nano-SiO2 nanoparticles can be used as composite reinforcing agents for preparation of starch-based films through extrusion blowing.
34019919	4	3	theme	blowing	1070:1076	arg1	process					1078:1084	the extrusion film blowing process	1051:1084	the extrusion film blowing process	1051:1084	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	4	4	theme	moisture	793:800	arg1	property					810:817	moisture barrier property	793:817	moisture barrier property	793:817	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	6	5	theme	blowing	1417:1423	arg1	extrusion					1407:1415	extrusion blowing	1407:1423	extrusion blowing	1407:1423	In sum, Nano-ZnO and nano-SiO2 nanoparticles can be used as composite reinforcing agents for preparation of starch-based films through extrusion blowing.
34019919	4	6	theme	tensile	775:781	arg1	strength					783:790	tensile strength	775:790	tensile strength	775:790	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	4	7	theme	film	1065:1068	arg1	process					1078:1084	the extrusion film blowing process	1051:1084	the extrusion film blowing process	1051:1084	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	3	8	theme	reinforced	734:743	arg1	films					745:749	the HS and nano-ZnO reinforced films	714:749	films	745:749	The diffraction patterns of nanocomposite films reinforced with nano-ZnO were similar to those of nano-ZnO, except that the peak intensity decreased, whereas, the addition of SiO2 nanoparticles decreased the intensity of the main characteristic peaks, regardless of the HS and nano-ZnO reinforced films.
34019919	5	9	theme	nano-ZnO/nano-SiO2	1102:1119	arg1	films					1142:1146	the nano-ZnO/nano-SiO2 composite-reinforced films	1098:1146	the nano-ZnO/nano-SiO2 composite-reinforced films	1098:1146	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	4	10	theme	films	864:868	arg1	property					810:817	moisture barrier property	793:817	moisture barrier property	793:817	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	4	10	theme	films	864:868	arg1	hydrophobicity					832:845	surface hydrophobicity	824:845	surface hydrophobicity	824:845	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	4	10	theme	films	864:868	arg1	stability					764:772	thermal stability	756:772	thermal stability	756:772	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	4	10	theme	films	864:868	arg1	strength					783:790	tensile strength	775:790	tensile strength	775:790	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	3	11	theme	diffraction	452:462	arg1	patterns					464:471	The diffraction patterns	448:471	The diffraction patterns of nanocomposite films reinforced with nano-ZnO	448:519	The diffraction patterns of nanocomposite films reinforced with nano-ZnO were similar to those of nano-ZnO, except that the peak intensity decreased, whereas, the addition of SiO2 nanoparticles decreased the intensity of the main characteristic peaks, regardless of the HS and nano-ZnO reinforced films.
34019919	3	11	theme	diffraction	452:462	arg1	similar					526:532	similar	526:532	similar	526:532	The diffraction patterns of nanocomposite films reinforced with nano-ZnO were similar to those of nano-ZnO, except that the peak intensity decreased, whereas, the addition of SiO2 nanoparticles decreased the intensity of the main characteristic peaks, regardless of the HS and nano-ZnO reinforced films.
34019919	6	12	theme	reinforcing	1342:1352	arg1	nanoparticles					1303:1315	Nano-ZnO and nano-SiO2 nanoparticles	1280:1315	Nano-ZnO and nano-SiO2 nanoparticles	1280:1315	In sum, Nano-ZnO and nano-SiO2 nanoparticles can be used as composite reinforcing agents for preparation of starch-based films through extrusion blowing.
34019919	6	12	theme	reinforcing	1342:1352	arg1	agents					1354:1359	composite reinforcing agents	1332:1359	composite reinforcing agents for preparation of starch-based films through extrusion blowing	1332:1423	In sum, Nano-ZnO and nano-SiO2 nanoparticles can be used as composite reinforcing agents for preparation of starch-based films through extrusion blowing.
34019919	5	13	theme	composite-reinforced	1121:1140	arg1	films					1142:1146	the nano-ZnO/nano-SiO2 composite-reinforced films	1098:1146	the nano-ZnO/nano-SiO2 composite-reinforced films	1098:1146	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	4	14	theme	nanocomposite	850:862	arg1	films					864:868	nanocomposite films	850:868	nanocomposite films	850:868	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	5	15	theme	force	1242:1246	arg1	AFM					1260:1262	AFM	1260:1262	AFM	1260:1262	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	5	15	theme	force	1242:1246	arg1	microscope					1248:1257	atomic force microscope	1235:1257	atomic force microscope (AFM) tests	1235:1269	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	1	16	theme	starch-based	194:205	arg1	films					207:211	starch-based films	194:211	starch-based films prepared by extrusion blowing	194:241	The effects of nano-ZnO and nano-SiO2 nanoparticles on the properties of starch-based films prepared by extrusion blowing were investigated in this study.
34019919	4	17	theme	starch	1030:1035	arg1	matrix					1037:1042	the starch matrix	1026:1042	the starch matrix during the extrusion film blowing process	1026:1084	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	3	18	theme	nano-ZnO	725:732	arg1	films					745:749	the HS and nano-ZnO reinforced films	714:749	films	745:749	The diffraction patterns of nanocomposite films reinforced with nano-ZnO were similar to those of nano-ZnO, except that the peak intensity decreased, whereas, the addition of SiO2 nanoparticles decreased the intensity of the main characteristic peaks, regardless of the HS and nano-ZnO reinforced films.
34019919	1	19	theme	films	207:211	arg1	properties					180:189	the properties	176:189	the properties of starch-based films prepared by extrusion blowing	176:241	The effects of nano-ZnO and nano-SiO2 nanoparticles on the properties of starch-based films prepared by extrusion blowing were investigated in this study.
34019919	5	20	theme	flat	1163:1166	arg1	appearances					1181:1191	smooth, flat, and uniform appearances	1155:1191	smooth, flat, and uniform appearances	1155:1191	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	5	21	theme	scanning	1196:1203	arg1	SEM					1226:1228	SEM	1226:1228	SEM	1226:1228	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	5	21	theme	scanning	1196:1203	arg1	microscopy					1214:1223	scanning electron microscopy	1196:1223	scanning electron microscopy (SEM)	1196:1229	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	6	22	theme	composite	1332:1340	arg1	nanoparticles					1303:1315	Nano-ZnO and nano-SiO2 nanoparticles	1280:1315	Nano-ZnO and nano-SiO2 nanoparticles	1280:1315	In sum, Nano-ZnO and nano-SiO2 nanoparticles can be used as composite reinforcing agents for preparation of starch-based films through extrusion blowing.
34019919	6	22	theme	composite	1332:1340	arg1	agents					1354:1359	composite reinforcing agents	1332:1359	composite reinforcing agents for preparation of starch-based films through extrusion blowing	1332:1423	In sum, Nano-ZnO and nano-SiO2 nanoparticles can be used as composite reinforcing agents for preparation of starch-based films through extrusion blowing.
34019919	3	23	theme	peak	572:575	arg1	intensity					577:585	the peak intensity	568:585	the peak intensity	568:585	The diffraction patterns of nanocomposite films reinforced with nano-ZnO were similar to those of nano-ZnO, except that the peak intensity decreased, whereas, the addition of SiO2 nanoparticles decreased the intensity of the main characteristic peaks, regardless of the HS and nano-ZnO reinforced films.
34019919	3	24	theme	films	490:494	arg1	patterns					464:471	The diffraction patterns	448:471	The diffraction patterns of nanocomposite films reinforced with nano-ZnO	448:519	The diffraction patterns of nanocomposite films reinforced with nano-ZnO were similar to those of nano-ZnO, except that the peak intensity decreased, whereas, the addition of SiO2 nanoparticles decreased the intensity of the main characteristic peaks, regardless of the HS and nano-ZnO reinforced films.
34019919	3	24	theme	films	490:494	arg1	similar					526:532	similar	526:532	similar	526:532	The diffraction patterns of nanocomposite films reinforced with nano-ZnO were similar to those of nano-ZnO, except that the peak intensity decreased, whereas, the addition of SiO2 nanoparticles decreased the intensity of the main characteristic peaks, regardless of the HS and nano-ZnO reinforced films.
34019919	5	25	theme	electron	1205:1212	arg1	SEM					1226:1228	SEM	1226:1228	SEM	1226:1228	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	5	25	theme	electron	1205:1212	arg1	microscopy					1214:1223	scanning electron microscopy	1196:1223	scanning electron microscopy (SEM)	1196:1229	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	4	26	theme	thermal	756:762	arg1	stability					764:772	thermal stability	756:772	thermal stability	756:772	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	0	27	theme	extrusion-blown	43:57	arg1	films					73:77	starch-based extrusion-blown nanocomposite films	30:77	starch-based extrusion-blown nanocomposite films	30:77	Preparation and evaluation of starch-based extrusion-blown nanocomposite films incorporated with nano-ZnO and nano-SiO2.
34019919	2	28	theme	extrusion	358:366	arg1	process					368:374	the extrusion process	354:374	the extrusion process	354:374	New hydrogen bonds between hydroxypropyl starch (HS) and nanoparticles during the extrusion process were formed as shown by Fourier transform infrared spectroscopy (FTIR).
34019919	4	29	theme	surface	824:830	arg1	hydrophobicity					832:845	surface hydrophobicity	824:845	surface hydrophobicity	824:845	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	1	30	theme	blowing	235:241	arg1	extrusion					225:233	extrusion blowing	225:241	extrusion blowing	225:241	The effects of nano-ZnO and nano-SiO2 nanoparticles on the properties of starch-based films prepared by extrusion blowing were investigated in this study.
34019919	0	31	theme	starch-based	30:41	arg1	films					73:77	starch-based extrusion-blown nanocomposite films	30:77	starch-based extrusion-blown nanocomposite films	30:77	Preparation and evaluation of starch-based extrusion-blown nanocomposite films incorporated with nano-ZnO and nano-SiO2.
34019919	3	32	theme	nanocomposite	476:488	arg1	films					490:494	nanocomposite films	476:494	nanocomposite films reinforced with nano-ZnO	476:519	The diffraction patterns of nanocomposite films reinforced with nano-ZnO were similar to those of nano-ZnO, except that the peak intensity decreased, whereas, the addition of SiO2 nanoparticles decreased the intensity of the main characteristic peaks, regardless of the HS and nano-ZnO reinforced films.
34019919	0	33	theme	films	73:77	arg1	evaluation					16:25	evaluation	16:25	evaluation	16:25	Preparation and evaluation of starch-based extrusion-blown nanocomposite films incorporated with nano-ZnO and nano-SiO2.
34019919	0	33	theme	films	73:77	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and evaluation of starch-based extrusion-blown nanocomposite films incorporated with nano-ZnO and nano-SiO2.
34019919	6	34	used	used	1324:1327	arg2	agents					1354:1359	composite reinforcing agents	1332:1359	composite reinforcing agents for preparation of starch-based films through extrusion blowing	1332:1423	In sum, Nano-ZnO and nano-SiO2 nanoparticles can be used as composite reinforcing agents for preparation of starch-based films through extrusion blowing.
34019919	6	34	used	used	1324:1327	arg2	nanoparticles					1303:1315	Nano-ZnO and nano-SiO2 nanoparticles	1280:1315	Nano-ZnO and nano-SiO2 nanoparticles	1280:1315	In sum, Nano-ZnO and nano-SiO2 nanoparticles can be used as composite reinforcing agents for preparation of starch-based films through extrusion blowing.
34019919	6	35	theme	films	1393:1397	arg1	preparation					1365:1375	preparation	1365:1375	preparation of starch-based films through extrusion blowing	1365:1423	In sum, Nano-ZnO and nano-SiO2 nanoparticles can be used as composite reinforcing agents for preparation of starch-based films through extrusion blowing.
34019919	4	36	dep	stability	764:772	arg1	The					752:754	The	752:754	The	752:754	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	0	37	theme	nanocomposite	59:71	arg1	films					73:77	starch-based extrusion-blown nanocomposite films	30:77	starch-based extrusion-blown nanocomposite films	30:77	Preparation and evaluation of starch-based extrusion-blown nanocomposite films incorporated with nano-ZnO and nano-SiO2.
34019919	5	38	theme	uniform	1173:1179	arg1	appearances					1181:1191	smooth, flat, and uniform appearances	1155:1191	smooth, flat, and uniform appearances	1155:1191	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	4	39	theme	nano-ZnO	910:917	arg1	incorporation					893:905	the incorporation	889:905	the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process	889:1084	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	3	40	theme	peaks	693:697	arg1	intensity					656:664	the intensity	652:664	the intensity of the main characteristic peaks	652:697	The diffraction patterns of nanocomposite films reinforced with nano-ZnO were similar to those of nano-ZnO, except that the peak intensity decreased, whereas, the addition of SiO2 nanoparticles decreased the intensity of the main characteristic peaks, regardless of the HS and nano-ZnO reinforced films.
34019919	1	41	theme	nano-ZnO	136:143	arg1	nanoparticles					159:171	nano-ZnO and nano-SiO2 nanoparticles	136:171	nano-ZnO and nano-SiO2 nanoparticles	136:171	The effects of nano-ZnO and nano-SiO2 nanoparticles on the properties of starch-based films prepared by extrusion blowing were investigated in this study.
34019919	3	42	theme	SiO2	623:626	arg1	nanoparticles					628:640	SiO2 nanoparticles	623:640	SiO2 nanoparticles	623:640	The diffraction patterns of nanocomposite films reinforced with nano-ZnO were similar to those of nano-ZnO, except that the peak intensity decreased, whereas, the addition of SiO2 nanoparticles decreased the intensity of the main characteristic peaks, regardless of the HS and nano-ZnO reinforced films.
34019919	6	43	theme	nano-SiO2	1293:1301	arg1	nanoparticles					1303:1315	Nano-ZnO and nano-SiO2 nanoparticles	1280:1315	Nano-ZnO and nano-SiO2 nanoparticles	1280:1315	In sum, Nano-ZnO and nano-SiO2 nanoparticles can be used as composite reinforcing agents for preparation of starch-based films through extrusion blowing.
34019919	6	43	theme	nano-SiO2	1293:1301	arg1	agents					1354:1359	composite reinforcing agents	1332:1359	composite reinforcing agents for preparation of starch-based films through extrusion blowing	1332:1423	In sum, Nano-ZnO and nano-SiO2 nanoparticles can be used as composite reinforcing agents for preparation of starch-based films through extrusion blowing.
34019919	3	44	theme	nanoparticles	628:640	arg1	addition					611:618	the addition	607:618	the addition of SiO2 nanoparticles	607:640	The diffraction patterns of nanocomposite films reinforced with nano-ZnO were similar to those of nano-ZnO, except that the peak intensity decreased, whereas, the addition of SiO2 nanoparticles decreased the intensity of the main characteristic peaks, regardless of the HS and nano-ZnO reinforced films.
34019919	2	45	dep	Fourier	400:406	arg1	transform					408:416	transform	408:416	transform infrared spectroscopy (FTIR)	408:445	New hydrogen bonds between hydroxypropyl starch (HS) and nanoparticles during the extrusion process were formed as shown by Fourier transform infrared spectroscopy (FTIR).
34019919	1	46	from	effects	125:131	arg1	properties					180:189	the properties	176:189	the properties of starch-based films prepared by extrusion blowing	176:241	The effects of nano-ZnO and nano-SiO2 nanoparticles on the properties of starch-based films prepared by extrusion blowing were investigated in this study.
34019919	5	47	theme	atomic	1235:1240	arg1	AFM					1260:1262	AFM	1260:1262	AFM	1260:1262	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	5	47	theme	atomic	1235:1240	arg1	microscope					1248:1257	atomic force microscope	1235:1257	atomic force microscope (AFM) tests	1235:1269	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	4	48	theme	nano-SiO2	923:931	arg1	incorporation					893:905	the incorporation	889:905	the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process	889:1084	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	3	49	theme	main	673:676	arg1	peaks					693:697	the main characteristic peaks	669:697	the main characteristic peaks	669:697	The diffraction patterns of nanocomposite films reinforced with nano-ZnO were similar to those of nano-ZnO, except that the peak intensity decreased, whereas, the addition of SiO2 nanoparticles decreased the intensity of the main characteristic peaks, regardless of the HS and nano-ZnO reinforced films.
34019919	2	50	theme	hydrogen	280:287	arg1	bonds					289:293	New hydrogen bonds	276:293	New hydrogen bonds between hydroxypropyl starch (HS) and nanoparticles during the extrusion process	276:374	New hydrogen bonds between hydroxypropyl starch (HS) and nanoparticles during the extrusion process were formed as shown by Fourier transform infrared spectroscopy (FTIR).
34019919	1	51	theme	nano-SiO2	149:157	arg1	nanoparticles					159:171	nano-ZnO and nano-SiO2 nanoparticles	136:171	nano-ZnO and nano-SiO2 nanoparticles	136:171	The effects of nano-ZnO and nano-SiO2 nanoparticles on the properties of starch-based films prepared by extrusion blowing were investigated in this study.
34019919	4	52	theme	barrier	802:808	arg1	property					810:817	moisture barrier property	793:817	moisture barrier property	793:817	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	3	53	theme	characteristic	678:691	arg1	peaks					693:697	the main characteristic peaks	669:697	the main characteristic peaks	669:697	The diffraction patterns of nanocomposite films reinforced with nano-ZnO were similar to those of nano-ZnO, except that the peak intensity decreased, whereas, the addition of SiO2 nanoparticles decreased the intensity of the main characteristic peaks, regardless of the HS and nano-ZnO reinforced films.
34019919	2	54	theme	New	276:278	arg1	bonds					289:293	New hydrogen bonds	276:293	New hydrogen bonds between hydroxypropyl starch (HS) and nanoparticles during the extrusion process	276:374	New hydrogen bonds between hydroxypropyl starch (HS) and nanoparticles during the extrusion process were formed as shown by Fourier transform infrared spectroscopy (FTIR).
34019919	1	55	theme	nanoparticles	159:171	arg1	effects					125:131	The effects	121:131	The effects of nano-ZnO and nano-SiO2 nanoparticles on the properties of starch-based films prepared by extrusion blowing	121:241	The effects of nano-ZnO and nano-SiO2 nanoparticles on the properties of starch-based films prepared by extrusion blowing were investigated in this study.
34019919	5	56	theme	microscope	1248:1257	arg1	tests					1265:1269	atomic force microscope (AFM) tests	1235:1269	atomic force microscope (AFM) tests	1235:1269	Similarly, the nano-ZnO/nano-SiO2 composite-reinforced films showed smooth, flat, and uniform appearances by scanning electron microscopy (SEM) and atomic force microscope (AFM) tests.
34019919	4	57	theme	strong	976:981	arg1	interplay					983:991	a strong interplay	974:991	a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process	974:1084	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
34019919	2	58	dep	transform	408:416	arg1	infrared					418:425	infrared	418:425	transform infrared spectroscopy (FTIR)	408:445	New hydrogen bonds between hydroxypropyl starch (HS) and nanoparticles during the extrusion process were formed as shown by Fourier transform infrared spectroscopy (FTIR).
34019919	4	59	theme	extrusion	1055:1063	arg1	process					1078:1084	the extrusion film blowing process	1051:1084	the extrusion film blowing process	1051:1084	The thermal stability, tensile strength, moisture barrier property, and surface hydrophobicity of nanocomposite films were improved with the incorporation of nano-ZnO and nano-SiO2, the finding that could be attributed to a strong interplay between nano-ZnO, nano-SiO2, and the starch matrix during the extrusion film blowing process.
33418348	0	0	theme	powerful	75:82	arg1	biomaterial					84:94	A powerful biomaterial	73:94	A powerful biomaterial for enhancing bioreactor performance to remove nitrate	73:149	Layered double hydroxide modified biochar combined with sodium alginate: A powerful biomaterial for enhancing bioreactor performance to remove nitrate.
33418348	1	1	theme	novel	154:158	arg1	SA					233:234	SA	233:234	SA	233:234	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	1	theme	novel	154:158	arg1	LBSA					238:241	LBSA	238:241	LBSA	238:241	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	1	theme	novel	154:158	arg1	alginate					223:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate	152:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	4	2	theme	response	539:546	arg1	methodology					556:566	The response surface methodology	535:566	The response surface methodology	535:566	The response surface methodology was used to illustrate the adsorption properties of the material and obtained optimal conditions for the removal of nitrate.
33418348	7	3	theme	Community	1126:1134	arg1	analysis					1146:1153	Community structure analysis	1126:1153	Community structure analysis	1126:1153	Community structure analysis and microbial distribution showed that FYF8 might was the dominant strain in bioreactors.
33418348	1	4	theme	layered	160:166	arg1	SA					233:234	SA	233:234	SA	233:234	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	4	theme	layered	160:166	arg1	LBSA					238:241	LBSA	238:241	LBSA	238:241	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	4	theme	layered	160:166	arg1	alginate					223:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate	152:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	6	5	theme	bacteria	983:990	arg1	composition					951:961	composition	951:961	composition	951:961	Moreover, the morphology and composition of LBSA immobilized bacteria were analyzed and the mechanism of removing nitrate and phosphate was the synergistic effect of biological metabolism and adsorption.
33418348	6	5	theme	bacteria	983:990	arg1	morphology					936:945	morphology	936:945	morphology	936:945	Moreover, the morphology and composition of LBSA immobilized bacteria were analyzed and the mechanism of removing nitrate and phosphate was the synergistic effect of biological metabolism and adsorption.
33418348	1	6	theme	Acinetobacter	306:318	arg1	sp					320:321	Acinetobacter sp	306:321	Acinetobacter sp	306:321	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	4	7	theme	material	624:631	arg1	properties					606:615	the adsorption properties	591:615	the adsorption properties of the material and obtained optimal conditions for the removal of nitrate	591:690	The response surface methodology was used to illustrate the adsorption properties of the material and obtained optimal conditions for the removal of nitrate.
33418348	6	8	theme	immobilized	971:981	arg1	bacteria					983:990	LBSA immobilized bacteria	966:990	LBSA immobilized bacteria	966:990	Moreover, the morphology and composition of LBSA immobilized bacteria were analyzed and the mechanism of removing nitrate and phosphate was the synergistic effect of biological metabolism and adsorption.
33418348	5	9	theme	adsorption	697:706	arg1	kinetics					708:715	The adsorption kinetics	693:715	The adsorption kinetics	693:715	The adsorption kinetics and isotherm were well fitted with the pseudo-second-order and Langmuir isotherm model, respectively, indicating that the adsorption process was mainly controlled by chemical adsorption and was favorable.
33418348	4	10	theme	surface	548:554	arg1	methodology					556:566	The response surface methodology	535:566	The response surface methodology	535:566	The response surface methodology was used to illustrate the adsorption properties of the material and obtained optimal conditions for the removal of nitrate.
33418348	0	11	theme	bioreactor	110:119	arg1	performance					121:131	bioreactor performance	110:131	bioreactor performance	110:131	Layered double hydroxide modified biochar combined with sodium alginate: A powerful biomaterial for enhancing bioreactor performance to remove nitrate.
33418348	2	12	theme	phosphorus	368:377	arg1	removal					344:350	the removal	340:350	the removal of nitrogen and phosphorus in the bioreactor	340:395	FYF8 to improve the removal of nitrogen and phosphorus in the bioreactor.
33418348	1	13	theme	double	168:173	arg1	SA					233:234	SA	233:234	SA	233:234	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	13	theme	double	168:173	arg1	LBSA					238:241	LBSA	238:241	LBSA	238:241	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	13	theme	double	168:173	arg1	alginate					223:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate	152:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	6	14	theme	LBSA	966:969	arg1	bacteria					983:990	LBSA immobilized bacteria	966:990	LBSA immobilized bacteria	966:990	Moreover, the morphology and composition of LBSA immobilized bacteria were analyzed and the mechanism of removing nitrate and phosphate was the synergistic effect of biological metabolism and adsorption.
33418348	5	15	theme	chemical	883:890	arg1	adsorption					892:901	chemical adsorption	883:901	chemical adsorption	883:901	The adsorption kinetics and isotherm were well fitted with the pseudo-second-order and Langmuir isotherm model, respectively, indicating that the adsorption process was mainly controlled by chemical adsorption and was favorable.
33418348	5	16	theme	Langmuir	780:787	arg1	model					798:802	the pseudo-second-order and Langmuir isotherm model	752:802	model	798:802	The adsorption kinetics and isotherm were well fitted with the pseudo-second-order and Langmuir isotherm model, respectively, indicating that the adsorption process was mainly controlled by chemical adsorption and was favorable.
33418348	5	17	theme	isotherm	789:796	arg1	model					798:802	the pseudo-second-order and Langmuir isotherm model	752:802	model	798:802	The adsorption kinetics and isotherm were well fitted with the pseudo-second-order and Langmuir isotherm model, respectively, indicating that the adsorption process was mainly controlled by chemical adsorption and was favorable.
33418348	1	18	theme	hydroxide	175:183	arg1	SA					233:234	SA	233:234	SA	233:234	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	18	theme	hydroxide	175:183	arg1	LBSA					238:241	LBSA	238:241	LBSA	238:241	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	18	theme	hydroxide	175:183	arg1	alginate					223:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate	152:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	0	19	theme	double	8:13	arg1	hydroxide					15:23	Layered double hydroxide	0:23	Layered double hydroxide	0:23	Layered double hydroxide modified biochar combined with sodium alginate: A powerful biomaterial for enhancing bioreactor performance to remove nitrate.
33418348	6	20	theme	synergistic	1066:1076	arg1	effect					1078:1083	the synergistic effect	1062:1083	the synergistic effect of biological metabolism and adsorption	1062:1123	Moreover, the morphology and composition of LBSA immobilized bacteria were analyzed and the mechanism of removing nitrate and phosphate was the synergistic effect of biological metabolism and adsorption.
33418348	6	20	theme	synergistic	1066:1076	arg1	mechanism					1014:1022	the mechanism	1010:1022	the mechanism of removing nitrate and phosphate	1010:1056	Moreover, the morphology and composition of LBSA immobilized bacteria were analyzed and the mechanism of removing nitrate and phosphate was the synergistic effect of biological metabolism and adsorption.
33418348	4	21	theme	obtained	637:644	arg1	conditions					654:663	obtained optimal conditions	637:663	obtained optimal conditions	637:663	The response surface methodology was used to illustrate the adsorption properties of the material and obtained optimal conditions for the removal of nitrate.
33418348	0	22	theme	Layered	0:6	arg1	hydroxide					15:23	Layered double hydroxide	0:23	Layered double hydroxide	0:23	Layered double hydroxide modified biochar combined with sodium alginate: A powerful biomaterial for enhancing bioreactor performance to remove nitrate.
33418348	7	23	theme	microbial	1159:1167	arg1	distribution					1169:1180	microbial distribution	1159:1180	microbial distribution	1159:1180	Community structure analysis and microbial distribution showed that FYF8 might was the dominant strain in bioreactors.
33418348	7	24	from	strain	1222:1227	arg1	bioreactors					1232:1242	bioreactors	1232:1242	bioreactors	1232:1242	Community structure analysis and microbial distribution showed that FYF8 might was the dominant strain in bioreactors.
33418348	1	25	theme	LDH	186:188	arg1	SA					233:234	SA	233:234	SA	233:234	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	25	theme	LDH	186:188	arg1	LBSA					238:241	LBSA	238:241	LBSA	238:241	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	25	theme	LDH	186:188	arg1	alginate					223:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate	152:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	7	26	dep	strain	1222:1227	arg1	might					1199:1203	might	1199:1203	might	1199:1203	Community structure analysis and microbial distribution showed that FYF8 might was the dominant strain in bioreactors.
33418348	4	27	theme	adsorption	595:604	arg1	properties					606:615	the adsorption properties	591:615	the adsorption properties of the material and obtained optimal conditions for the removal of nitrate	591:690	The response surface methodology was used to illustrate the adsorption properties of the material and obtained optimal conditions for the removal of nitrate.
33418348	1	28	theme	synthetic	244:252	arg1	material					254:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	28	theme	synthetic	244:252	arg1	carrier					294:300	an immobilized carrier	279:300	an immobilized carrier for Acinetobacter sp	279:321	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	3	29	theme	phosphate	466:474	arg1	efficiency					484:493	the nitrate and phosphate removal efficiency	450:493	efficiency	484:493	Results demonstrated that under optimum conditions, the nitrate and phosphate removal efficiency reached 95.32 and 86.11%, respectively.
33418348	1	30	theme	-orange	190:196	arg1	SA					233:234	SA	233:234	SA	233:234	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	30	theme	-orange	190:196	arg1	LBSA					238:241	LBSA	238:241	LBSA	238:241	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	30	theme	-orange	190:196	arg1	alginate					223:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate	152:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	31	theme	peel	198:201	arg1	SA					233:234	SA	233:234	SA	233:234	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	31	theme	peel	198:201	arg1	LBSA					238:241	LBSA	238:241	LBSA	238:241	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	31	theme	peel	198:201	arg1	alginate					223:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate	152:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	4	32	theme	conditions	654:663	arg1	properties					606:615	the adsorption properties	591:615	the adsorption properties of the material and obtained optimal conditions for the removal of nitrate	591:690	The response surface methodology was used to illustrate the adsorption properties of the material and obtained optimal conditions for the removal of nitrate.
33418348	4	33	used	used	572:575	arg2	methodology					556:566	The response surface methodology	535:566	The response surface methodology	535:566	The response surface methodology was used to illustrate the adsorption properties of the material and obtained optimal conditions for the removal of nitrate.
33418348	2	34	theme	nitrogen	355:362	arg1	removal					344:350	the removal	340:350	the removal of nitrogen and phosphorus in the bioreactor	340:395	FYF8 to improve the removal of nitrogen and phosphorus in the bioreactor.
33418348	0	35	theme	sodium	56:61	arg1	alginate					63:70	sodium alginate	56:70	sodium alginate	56:70	Layered double hydroxide modified biochar combined with sodium alginate: A powerful biomaterial for enhancing bioreactor performance to remove nitrate.
33418348	6	36	theme	metabolism	1099:1108	arg1	effect					1078:1083	the synergistic effect	1062:1083	the synergistic effect of biological metabolism and adsorption	1062:1123	Moreover, the morphology and composition of LBSA immobilized bacteria were analyzed and the mechanism of removing nitrate and phosphate was the synergistic effect of biological metabolism and adsorption.
33418348	6	36	theme	metabolism	1099:1108	arg1	mechanism					1014:1022	the mechanism	1010:1022	the mechanism of removing nitrate and phosphate	1010:1056	Moreover, the morphology and composition of LBSA immobilized bacteria were analyzed and the mechanism of removing nitrate and phosphate was the synergistic effect of biological metabolism and adsorption.
33418348	3	37	theme	optimum	430:436	arg1	conditions					438:447	optimum conditions	430:447	optimum conditions	430:447	Results demonstrated that under optimum conditions, the nitrate and phosphate removal efficiency reached 95.32 and 86.11%, respectively.
33418348	2	38	attach	removal	344:350	arg3	bioreactor					386:395	the bioreactor	382:395	the bioreactor	382:395	FYF8 to improve the removal of nitrogen and phosphorus in the bioreactor.
33418348	2	38	attach	removal	344:350	arg2	nitrogen					355:362	nitrogen	355:362	nitrogen	355:362	FYF8 to improve the removal of nitrogen and phosphorus in the bioreactor.
33418348	2	38	attach	removal	344:350	arg2	phosphorus					368:377	phosphorus	368:377	phosphorus	368:377	FYF8 to improve the removal of nitrogen and phosphorus in the bioreactor.
33418348	7	39	theme	dominant	1213:1220	arg1	strain					1222:1227	the dominant strain	1209:1227	the dominant strain in bioreactors	1209:1242	Community structure analysis and microbial distribution showed that FYF8 might was the dominant strain in bioreactors.
33418348	7	39	theme	dominant	1213:1220	arg1	FYF8					1194:1197	FYF8	1194:1197	FYF8	1194:1197	Community structure analysis and microbial distribution showed that FYF8 might was the dominant strain in bioreactors.
33418348	6	40	dep	morphology	936:945	arg1	the					932:934	the	932:934	the	932:934	Moreover, the morphology and composition of LBSA immobilized bacteria were analyzed and the mechanism of removing nitrate and phosphate was the synergistic effect of biological metabolism and adsorption.
33418348	2	41	from	removal	344:350	arg1	bioreactor					386:395	the bioreactor	382:395	the bioreactor	382:395	FYF8 to improve the removal of nitrogen and phosphorus in the bioreactor.
33418348	6	42	theme	adsorption	1114:1123	arg1	effect					1078:1083	the synergistic effect	1062:1083	the synergistic effect of biological metabolism and adsorption	1062:1123	Moreover, the morphology and composition of LBSA immobilized bacteria were analyzed and the mechanism of removing nitrate and phosphate was the synergistic effect of biological metabolism and adsorption.
33418348	6	42	theme	adsorption	1114:1123	arg1	mechanism					1014:1022	the mechanism	1010:1022	the mechanism of removing nitrate and phosphate	1010:1056	Moreover, the morphology and composition of LBSA immobilized bacteria were analyzed and the mechanism of removing nitrate and phosphate was the synergistic effect of biological metabolism and adsorption.
33418348	1	43	theme	OP	204:205	arg1	SA					233:234	SA	233:234	SA	233:234	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	43	theme	OP	204:205	arg1	LBSA					238:241	LBSA	238:241	LBSA	238:241	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	43	theme	OP	204:205	arg1	alginate					223:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate	152:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	4	44	theme	nitrate	684:690	arg1	removal					673:679	the removal	669:679	the removal of nitrate	669:690	The response surface methodology was used to illustrate the adsorption properties of the material and obtained optimal conditions for the removal of nitrate.
33418348	6	45	theme	biological	1088:1097	arg1	metabolism					1099:1108	biological metabolism	1088:1108	biological metabolism	1088:1108	Moreover, the morphology and composition of LBSA immobilized bacteria were analyzed and the mechanism of removing nitrate and phosphate was the synergistic effect of biological metabolism and adsorption.
33418348	4	46	dep	material	624:631	arg1	the					620:622	the	620:622	the	620:622	The response surface methodology was used to illustrate the adsorption properties of the material and obtained optimal conditions for the removal of nitrate.
33418348	3	47	theme	removal	476:482	arg1	efficiency					484:493	the nitrate and phosphate removal efficiency	450:493	efficiency	484:493	Results demonstrated that under optimum conditions, the nitrate and phosphate removal efficiency reached 95.32 and 86.11%, respectively.
33418348	5	48	theme	adsorption	839:848	arg1	process					850:856	the adsorption process	835:856	the adsorption process	835:856	The adsorption kinetics and isotherm were well fitted with the pseudo-second-order and Langmuir isotherm model, respectively, indicating that the adsorption process was mainly controlled by chemical adsorption and was favorable.
33418348	5	48	theme	adsorption	839:848	arg1	favorable					911:919	favorable	911:919	favorable	911:919	The adsorption kinetics and isotherm were well fitted with the pseudo-second-order and Langmuir isotherm model, respectively, indicating that the adsorption process was mainly controlled by chemical adsorption and was favorable.
33418348	1	49	theme	biochar/sodium	208:221	arg1	SA					233:234	SA	233:234	SA	233:234	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	49	theme	biochar/sodium	208:221	arg1	LBSA					238:241	LBSA	238:241	LBSA	238:241	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	49	theme	biochar/sodium	208:221	arg1	alginate					223:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate	152:230	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	7	50	theme	structure	1136:1144	arg1	analysis					1146:1153	Community structure analysis	1126:1153	Community structure analysis	1126:1153	Community structure analysis and microbial distribution showed that FYF8 might was the dominant strain in bioreactors.
33418348	1	51	theme	immobilized	282:292	arg1	material					254:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	51	theme	immobilized	282:292	arg1	carrier					294:300	an immobilized carrier	279:300	an immobilized carrier for Acinetobacter sp	279:321	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	4	52	theme	optimal	646:652	arg1	conditions					654:663	obtained optimal conditions	637:663	obtained optimal conditions	637:663	The response surface methodology was used to illustrate the adsorption properties of the material and obtained optimal conditions for the removal of nitrate.
33418348	1	53	theme	alginate	223:230	arg1	material					254:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material	152:261	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
33418348	1	53	theme	alginate	223:230	arg1	carrier					294:300	an immobilized carrier	279:300	an immobilized carrier for Acinetobacter sp	279:321	A novel layered double hydroxide (LDH)-orange peel (OP) biochar/sodium alginate (SA) (LBSA) synthetic material was prepared as an immobilized carrier for Acinetobacter sp.
34486109	17	0	theme	microscopic	2451:2461	arg1	investigation					2463:2475	The microscopic investigation	2447:2475	The microscopic investigation	2447:2475	The microscopic investigation did not confirm their neural identity and therefore, this study disclaims the existence of a parasympathetic ASN in both mice and human.
34486109	2	1	theme	ASN	310:312	arg1	stimulation					291:301	Electrical stimulation	280:301	Electrical stimulation of the ASN	280:312	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	3	2	located	present	559:565	arg1	humans					570:575	humans	570:575	humans	570:575	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	3	2	located	present	559:565	arg2	present					559:565	present	559:565	present	559:565	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	3	2	located	present	559:565	arg2	ASN					546:548	such a discrete ASN	530:548	such a discrete ASN	530:548	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	7	3	theme	ASN	1070:1072	arg1	composition					1074:1084	ASN composition	1070:1084	ASN composition	1070:1084	Microscopic techniques were applied to confirm nerve identity and compare ASN composition.
34486109	8	4	theme	human	1104:1108	arg1	cadavers					1110:1117	six human cadavers	1100:1117	six human cadavers	1100:1117	Six mice and six human cadavers were used to study and compare the ASN, both macro- and microscopically.
34486109	1	5	theme	spleen	141:146	arg1	pole					123:126	The cranial pole	111:126	The cranial pole of the mouse spleen	111:146	The cranial pole of the mouse spleen is considered to be parasympathetically innervated by a macroscopic observable nerve referred to as the apical splenic nerve (ASN).
34486109	17	6	theme	ASN	2586:2588	arg1	existence					2555:2563	the existence	2551:2563	the existence of a parasympathetic ASN in both mice and human	2551:2611	The microscopic investigation did not confirm their neural identity and therefore, this study disclaims the existence of a parasympathetic ASN in both mice and human.
34486109	12	7	theme	phrenicosplenic	1674:1688	arg1	ligament					1690:1697	the phrenicosplenic ligament	1670:1697	the phrenicosplenic ligament connecting the diaphragm and apical pole of the spleen	1670:1752	Macroscopically, the ASN could be clearly identified in all mice and was running in the phrenicosplenic ligament connecting the diaphragm and apical pole of the spleen.
34486109	3	8	theme	inflammatory	716:727	arg1	diseases					729:736	immune-mediated inflammatory diseases	700:736	immune-mediated inflammatory diseases	700:736	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	3	9	theme	discrete	537:544	arg1	ASN					546:548	such a discrete ASN	530:548	such a discrete ASN	530:548	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	3	9	theme	discrete	537:544	arg1	present					559:565	present	559:565	present	559:565	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	8	10	used	used	1124:1127	arg2	cadavers					1110:1117	six human cadavers	1100:1117	six human cadavers	1100:1117	Six mice and six human cadavers were used to study and compare the ASN, both macro- and microscopically.
34486109	8	10	used	used	1124:1127	arg2	mice					1091:1094	Six mice	1087:1094	Six mice	1087:1094	Six mice and six human cadavers were used to study and compare the ASN, both macro- and microscopically.
34486109	12	11	from	running	1659:1665	arg1	ligament					1690:1697	the phrenicosplenic ligament	1670:1697	the phrenicosplenic ligament connecting the diaphragm and apical pole of the spleen	1670:1752	Macroscopically, the ASN could be clearly identified in all mice and was running in the phrenicosplenic ligament connecting the diaphragm and apical pole of the spleen.
34486109	15	12	theme	tissue	2241:2246	arg1	strains					2248:2254	connective tissue strains	2230:2254	connective tissue strains	2230:2254	Microscopic evaluation of the ASN in mice and human showed that this structure did not represent a nerve, but most likely connective tissue strains.
34486109	10	13	from	sections	1378:1385	arg1	resected					1329:1336	resected	1329:1336	resected	1329:1336	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	14	14	dep	white	2011:2015	arg1	potential					2018:2026	potential	2018:2026	potential	2018:2026	Since the gastrosplenic ligament was a continuation of the phrenicosplenic ligament, this ligament was explored as well and contained white, potential discrete nerve-like structures as well which could represent an ANS equivalent.
34486109	0	15	from	presence	55:62	arg1	humans					103:108	humans	103:108	humans	103:108	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans.
34486109	0	15	from	presence	55:62	arg1	mice					94:97	mice	94:97	mice	94:97	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans.
34486109	13	16	theme	structures	1852:1861	arg1	configuration					1818:1830	a similar configuration	1808:1830	a similar configuration of potential neural structures	1808:1861	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	9	17	theme	morphological	1204:1216	arg1	characteristics					1218:1232	Macroscopic morphological characteristics	1192:1232	Macroscopic morphological characteristics of the ASN in both mice and humans	1192:1267	Macroscopic morphological characteristics of the ASN in both mice and humans were described and photographs were taken.
34486109	5	18	theme	ASN	880:882	arg1	location					853:860	location	853:860	location	853:860	This study aimed to provide a detailed description of the location and course of the ASN in mice.
34486109	5	18	theme	ASN	880:882	arg1	course					866:871	course	866:871	course	866:871	This study aimed to provide a detailed description of the location and course of the ASN in mice.
34486109	15	19	from	evaluation	2120:2129	arg1	mice					2145:2148	mice	2145:2148	mice	2145:2148	Microscopic evaluation of the ASN in mice and human showed that this structure did not represent a nerve, but most likely connective tissue strains.
34486109	15	19	from	evaluation	2120:2129	arg1	human					2154:2158	human	2154:2158	human	2154:2158	Microscopic evaluation of the ASN in mice and human showed that this structure did not represent a nerve, but most likely connective tissue strains.
34486109	10	20	theme	thin	1373:1376	arg1	sections					1378:1385	5 μm thin sections	1368:1385	5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively	1368:1503	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	17	21	theme	parasympathetic	2570:2584	arg1	ASN					2586:2588	a parasympathetic ASN	2568:2588	a parasympathetic ASN	2568:2588	The microscopic investigation did not confirm their neural identity and therefore, this study disclaims the existence of a parasympathetic ASN in both mice and human.
34486109	12	22	dep	diaphragm	1714:1722	arg1	the					1710:1712	the	1710:1712	the	1710:1712	Macroscopically, the ASN could be clearly identified in all mice and was running in the phrenicosplenic ligament connecting the diaphragm and apical pole of the spleen.
34486109	16	23	from	ligament	2427:2434	arg1	humans					2439:2444	humans	2439:2444	humans	2439:2444	White nerve-like structures, which could represent the ASN, were macroscopically observed in the phrenicosplenic ligament in both mice and human and in the gastrosplenic ligament in humans.
34486109	9	24	theme	ASN	1241:1243	arg1	characteristics					1218:1232	Macroscopic morphological characteristics	1192:1232	Macroscopic morphological characteristics of the ASN in both mice and humans	1192:1267	Macroscopic morphological characteristics of the ASN in both mice and humans were described and photographs were taken.
34486109	5	25	from	location	853:860	arg1	mice					887:890	mice	887:890	mice	887:890	This study aimed to provide a detailed description of the location and course of the ASN in mice.
34486109	3	26	attach	present	559:565	arg1	humans					570:575	humans	570:575	humans	570:575	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	3	26	attach	present	559:565	arg2	ASN					546:548	such a discrete ASN	530:548	such a discrete ASN	530:548	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	3	26	attach	present	559:565	arg2	present					559:565	present	559:565	present	559:565	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	2	27	theme	rheumatoid	505:514	arg1	arthritis					516:524	rheumatoid arthritis	505:524	rheumatoid arthritis	505:524	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	13	28	theme	potential	1835:1843	arg1	structures					1852:1861	potential neural structures	1835:1861	potential neural structures	1835:1861	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	0	29	theme	splenic	77:83	arg1	nerve					85:89	an apical splenic nerve	67:89	an apical splenic nerve	67:89	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans.
34486109	10	30	theme	adjacent	1399:1406	arg1	sections					1408:1415	adjacent sections	1399:1415	adjacent sections	1399:1415	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	17	31	theme	neural	2499:2504	arg1	identity					2506:2513	their neural identity	2493:2513	their neural identity	2493:2513	The microscopic investigation did not confirm their neural identity and therefore, this study disclaims the existence of a parasympathetic ASN in both mice and human.
34486109	2	32	theme	acetylcholine	354:366	arg1	levels					336:341	increased levels	326:341	increased levels of splenic acetylcholine	326:366	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	13	33	attach	present	1789:1795	arg1	humans					1800:1805	humans	1800:1805	humans	1800:1805	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	13	33	attach	present	1789:1795	arg2	present					1789:1795	present	1789:1795	present	1789:1795	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	13	33	attach	present	1789:1795	arg2	ligament					1776:1783	a phrenicosplenic ligament	1758:1783	a phrenicosplenic ligament	1758:1783	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	2	34	theme	necrosis	431:438	arg1	alpha					447:451	systemic tumor necrosis factor alpha	416:451	systemic tumor necrosis factor alpha	416:451	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	14	35	theme	nerve-like	2037:2046	arg1	structures					2048:2057	white, potential discrete nerve-like structures	2011:2057	white, potential discrete nerve-like structures	2011:2057	Since the gastrosplenic ligament was a continuation of the phrenicosplenic ligament, this ligament was explored as well and contained white, potential discrete nerve-like structures as well which could represent an ANS equivalent.
34486109	5	36	dep	location	853:860	arg1	the					849:851	the	849:851	the	849:851	This study aimed to provide a detailed description of the location and course of the ASN in mice.
34486109	5	37	from	course	866:871	arg1	mice					887:890	mice	887:890	mice	887:890	This study aimed to provide a detailed description of the location and course of the ASN in mice.
34486109	14	38	theme	phrenicosplenic	1936:1950	arg1	ligament					1952:1959	the phrenicosplenic ligament	1932:1959	the phrenicosplenic ligament	1932:1959	Since the gastrosplenic ligament was a continuation of the phrenicosplenic ligament, this ligament was explored as well and contained white, potential discrete nerve-like structures as well which could represent an ANS equivalent.
34486109	2	39	theme	systemic	416:423	arg1	alpha					447:451	systemic tumor necrosis factor alpha	416:451	systemic tumor necrosis factor alpha	416:451	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	3	40	from	present	559:565	arg1	humans					570:575	humans	570:575	humans	570:575	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	0	41	theme	anatomical	14:23	arg1	study					42:46	A comparative anatomical and histological study	0:46	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans	0:108	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans.
34486109	1	42	theme	splenic	259:265	arg1	ASN					274:276	ASN	274:276	ASN	274:276	The cranial pole of the mouse spleen is considered to be parasympathetically innervated by a macroscopic observable nerve referred to as the apical splenic nerve (ASN).
34486109	1	42	theme	splenic	259:265	arg1	nerve					267:271	the apical splenic nerve	248:271	the apical splenic nerve (ASN)	248:277	The cranial pole of the mouse spleen is considered to be parasympathetically innervated by a macroscopic observable nerve referred to as the apical splenic nerve (ASN).
34486109	8	43	dep	both	1159:1162	arg1	macro-					1164:1169	macro-	1164:1169	macro-	1164:1169	Six mice and six human cadavers were used to study and compare the ASN, both macro- and microscopically.
34486109	14	44	theme	white	2011:2015	arg1	structures					2048:2057	white, potential discrete nerve-like structures	2011:2057	white, potential discrete nerve-like structures	2011:2057	Since the gastrosplenic ligament was a continuation of the phrenicosplenic ligament, this ligament was explored as well and contained white, potential discrete nerve-like structures as well which could represent an ANS equivalent.
34486109	3	45	from	humans	570:575	arg1	ASN					546:548	such a discrete ASN	530:548	such a discrete ASN	530:548	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	3	45	from	humans	570:575	arg1	present					559:565	present	559:565	present	559:565	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	0	46	theme	histological	29:40	arg1	study					42:46	A comparative anatomical and histological study	0:46	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans	0:108	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans.
34486109	13	47	from	present	1789:1795	arg1	humans					1800:1805	humans	1800:1805	humans	1800:1805	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	0	48	attach	presence	55:62	arg2	nerve					85:89	an apical splenic nerve	67:89	an apical splenic nerve	67:89	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans.
34486109	0	48	attach	presence	55:62	arg1	humans					103:108	humans	103:108	humans	103:108	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans.
34486109	0	48	attach	presence	55:62	arg1	mice					94:97	mice	94:97	mice	94:97	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans.
34486109	6	49	theme	structure	975:983	arg1	exploration					946:956	a guided exploration	937:956	a guided exploration of an equivalent structure in humans	937:993	Subsequently, this information was used for a guided exploration of an equivalent structure in humans.
34486109	2	50	theme	alpha	447:451	arg1	levels					406:411	lipopolysaccharide-induced levels	379:411	lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha	379:451	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	16	51	theme	gastrosplenic	2413:2425	arg1	ligament					2427:2434	the gastrosplenic ligament	2409:2434	the gastrosplenic ligament in humans	2409:2444	White nerve-like structures, which could represent the ASN, were macroscopically observed in the phrenicosplenic ligament in both mice and human and in the gastrosplenic ligament in humans.
34486109	11	52	theme	fiber	1532:1536	arg1	composition					1538:1548	nerve fiber composition	1526:1548	nerve fiber composition	1526:1548	Neural identity and nerve fiber composition was then evaluated microscopically.
34486109	10	53	theme	general	1437:1443	arg1	marker					1484:1489	a general, sympathetic and parasympathetic nerve marker	1435:1489	a general, sympathetic and parasympathetic nerve marker	1435:1489	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	6	54	from	structure	975:983	arg1	humans					988:993	humans	988:993	humans	988:993	Subsequently, this information was used for a guided exploration of an equivalent structure in humans.
34486109	10	55	from	resected	1329:1336	arg1	sections					1378:1385	5 μm thin sections	1368:1385	5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively	1368:1503	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	4	56	theme	human	766:770	arg1	equivalent					776:785	a human ASN equivalent	764:785	a human ASN equivalent	764:785	So far, it is unknown if a human ASN equivalent exists.
34486109	2	57	theme	increased	326:334	arg1	levels					336:341	increased levels	326:341	increased levels of splenic acetylcholine	326:366	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	5	58	from	mice	887:890	arg1	description					834:844	a detailed description	823:844	a detailed description of the location and course of the ASN in mice	823:890	This study aimed to provide a detailed description of the location and course of the ASN in mice.
34486109	1	59	theme	macroscopic	204:214	arg1	nerve					227:231	a macroscopic observable nerve	202:231	a macroscopic observable nerve referred to as the apical splenic nerve (ASN)	202:277	The cranial pole of the mouse spleen is considered to be parasympathetically innervated by a macroscopic observable nerve referred to as the apical splenic nerve (ASN).
34486109	9	60	from	characteristics	1218:1232	arg1	mice					1253:1256	mice	1253:1256	mice	1253:1256	Macroscopic morphological characteristics of the ASN in both mice and humans were described and photographs were taken.
34486109	9	60	from	characteristics	1218:1232	arg1	humans					1262:1267	humans	1262:1267	humans	1262:1267	Macroscopic morphological characteristics of the ASN in both mice and humans were described and photographs were taken.
34486109	13	61	from	humans	1800:1805	arg1	present					1789:1795	present	1789:1795	present	1789:1795	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	13	61	from	humans	1800:1805	arg1	ligament					1776:1783	a phrenicosplenic ligament	1758:1783	a phrenicosplenic ligament	1758:1783	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	10	62	from	embedded	1339:1346	arg1	paraffin					1351:1358	paraffin	1351:1358	paraffin	1351:1358	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	16	63	located	observed	2338:2345	arg2	structures					2274:2283	White nerve-like structures	2257:2283	White nerve-like structures	2257:2283	White nerve-like structures, which could represent the ASN, were macroscopically observed in the phrenicosplenic ligament in both mice and human and in the gastrosplenic ligament in humans.
34486109	16	63	located	observed	2338:2345	arg1	ligament					2370:2377	the phrenicosplenic ligament	2350:2377	the phrenicosplenic ligament	2350:2377	White nerve-like structures, which could represent the ASN, were macroscopically observed in the phrenicosplenic ligament in both mice and human and in the gastrosplenic ligament in humans.
34486109	16	63	located	observed	2338:2345	arg1	mice					2387:2390	mice	2387:2390	mice	2387:2390	White nerve-like structures, which could represent the ASN, were macroscopically observed in the phrenicosplenic ligament in both mice and human and in the gastrosplenic ligament in humans.
34486109	3	64	theme	stimulation	672:682	arg1	target					684:689	a relatively easily accessible electrical stimulation target	630:689	a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases	630:736	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	6	65	used	used	928:931	arg2	information					912:922	this information	907:922	this information	907:922	Subsequently, this information was used for a guided exploration of an equivalent structure in humans.
34486109	15	66	theme	connective	2230:2239	arg1	strains					2248:2254	connective tissue strains	2230:2254	connective tissue strains	2230:2254	Microscopic evaluation of the ASN in mice and human showed that this structure did not represent a nerve, but most likely connective tissue strains.
34486109	10	67	from	paraffin	1351:1358	arg1	embedded					1339:1346	embedded	1339:1346	embedded	1339:1346	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	3	68	theme	accessible	650:659	arg1	target					684:689	a relatively easily accessible electrical stimulation target	630:689	a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases	630:736	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	10	69	dep	resected	1329:1336	arg1	cut					1361:1363	cut	1361:1363	cut	1361:1363	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	10	69	dep	resected	1329:1336	arg1	embedded					1339:1346	embedded	1339:1346	embedded	1339:1346	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	15	70	theme	ASN	2138:2140	arg1	evaluation					2120:2129	Microscopic evaluation	2108:2129	Microscopic evaluation of the ASN in mice and human	2108:2158	Microscopic evaluation of the ASN in mice and human showed that this structure did not represent a nerve, but most likely connective tissue strains.
34486109	3	71	theme	immune-mediated	700:714	arg1	diseases					729:736	immune-mediated inflammatory diseases	700:736	immune-mediated inflammatory diseases	700:736	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	7	72	theme	nerve	1043:1047	arg1	identity					1049:1056	nerve identity	1043:1056	nerve identity	1043:1056	Microscopic techniques were applied to confirm nerve identity and compare ASN composition.
34486109	15	73	theme	Microscopic	2108:2118	arg1	evaluation					2120:2129	Microscopic evaluation	2108:2129	Microscopic evaluation of the ASN in mice and human	2108:2158	Microscopic evaluation of the ASN in mice and human showed that this structure did not represent a nerve, but most likely connective tissue strains.
34486109	1	74	theme	mouse	135:139	arg1	spleen					141:146	the mouse spleen	131:146	the mouse spleen	131:146	The cranial pole of the mouse spleen is considered to be parasympathetically innervated by a macroscopic observable nerve referred to as the apical splenic nerve (ASN).
34486109	13	75	located	present	1789:1795	arg1	humans					1800:1805	humans	1800:1805	humans	1800:1805	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	13	75	located	present	1789:1795	arg2	present					1789:1795	present	1789:1795	present	1789:1795	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	13	75	located	present	1789:1795	arg2	ligament					1776:1783	a phrenicosplenic ligament	1758:1783	a phrenicosplenic ligament	1758:1783	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	11	76	theme	Neural	1506:1511	arg1	identity					1513:1520	Neural identity	1506:1520	Neural identity	1506:1520	Neural identity and nerve fiber composition was then evaluated microscopically.
34486109	5	77	theme	detailed	825:832	arg1	description					834:844	a detailed description	823:844	a detailed description of the location and course of the ASN in mice	823:890	This study aimed to provide a detailed description of the location and course of the ASN in mice.
34486109	10	78	theme	5 μm	1368:1371	arg1	sections					1378:1385	5 μm thin sections	1368:1385	5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively	1368:1503	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	6	79	from	humans	988:993	arg1	exploration					946:956	a guided exploration	937:956	a guided exploration of an equivalent structure in humans	937:993	Subsequently, this information was used for a guided exploration of an equivalent structure in humans.
34486109	2	80	from	symptoms	476:483	arg1	model					496:500	a mouse model	488:500	a mouse model of rheumatoid arthritis	488:524	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	7	81	theme	Microscopic	996:1006	arg1	techniques					1008:1017	Microscopic techniques	996:1017	Microscopic techniques	996:1017	Microscopic techniques were applied to confirm nerve identity and compare ASN composition.
34486109	2	82	theme	arthritis	516:524	arg1	model					496:500	a mouse model	488:500	a mouse model of rheumatoid arthritis	488:524	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	14	83	theme	ANS	2092:2094	arg1	equivalent					2096:2105	an ANS equivalent	2089:2105	an ANS equivalent	2089:2105	Since the gastrosplenic ligament was a continuation of the phrenicosplenic ligament, this ligament was explored as well and contained white, potential discrete nerve-like structures as well which could represent an ANS equivalent.
34486109	5	84	theme	course	866:871	arg1	description					834:844	a detailed description	823:844	a detailed description of the location and course of the ASN in mice	823:890	This study aimed to provide a detailed description of the location and course of the ASN in mice.
34486109	13	85	theme	neural	1845:1850	arg1	structures					1852:1861	potential neural structures	1835:1861	potential neural structures	1835:1861	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	9	86	theme	Macroscopic	1192:1202	arg1	characteristics					1218:1232	Macroscopic morphological characteristics	1192:1232	Macroscopic morphological characteristics of the ASN in both mice and humans	1192:1267	Macroscopic morphological characteristics of the ASN in both mice and humans were described and photographs were taken.
34486109	6	87	theme	equivalent	964:973	arg1	structure					975:983	an equivalent structure	961:983	an equivalent structure in humans	961:993	Subsequently, this information was used for a guided exploration of an equivalent structure in humans.
34486109	10	88	dep	general	1437:1443	arg1	parasympathetic					1462:1476	parasympathetic	1462:1476	parasympathetic	1462:1476	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	10	88	dep	general	1437:1443	arg1	sympathetic					1446:1456	sympathetic	1446:1456	sympathetic	1446:1456	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	16	89	theme	White	2257:2261	arg1	structures					2274:2283	White nerve-like structures	2257:2283	White nerve-like structures	2257:2283	White nerve-like structures, which could represent the ASN, were macroscopically observed in the phrenicosplenic ligament in both mice and human and in the gastrosplenic ligament in humans.
34486109	5	90	from	description	834:844	arg1	mice					887:890	mice	887:890	mice	887:890	This study aimed to provide a detailed description of the location and course of the ASN in mice.
34486109	1	91	theme	cranial	115:121	arg1	pole					123:126	The cranial pole	111:126	The cranial pole of the mouse spleen	111:146	The cranial pole of the mouse spleen is considered to be parasympathetically innervated by a macroscopic observable nerve referred to as the apical splenic nerve (ASN).
34486109	13	92	theme	similar	1810:1816	arg1	configuration					1818:1830	a similar configuration	1808:1830	a similar configuration of potential neural structures	1808:1861	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	0	93	theme	apical	70:75	arg1	nerve					85:89	an apical splenic nerve	67:89	an apical splenic nerve	67:89	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans.
34486109	5	94	theme	location	853:860	arg1	description					834:844	a detailed description	823:844	a detailed description of the location and course of the ASN in mice	823:890	This study aimed to provide a detailed description of the location and course of the ASN in mice.
34486109	6	95	theme	guided	939:944	arg1	exploration					946:956	a guided exploration	937:956	a guided exploration of an equivalent structure in humans	937:993	Subsequently, this information was used for a guided exploration of an equivalent structure in humans.
34486109	2	96	theme	clinical	467:474	arg1	symptoms					476:483	clinical symptoms	467:483	clinical symptoms in a mouse model of rheumatoid arthritis	467:524	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	6	97	from	exploration	946:956	arg1	humans					988:993	humans	988:993	humans	988:993	Subsequently, this information was used for a guided exploration of an equivalent structure in humans.
34486109	16	98	theme	nerve-like	2263:2272	arg1	structures					2274:2283	White nerve-like structures	2257:2283	White nerve-like structures	2257:2283	White nerve-like structures, which could represent the ASN, were macroscopically observed in the phrenicosplenic ligament in both mice and human and in the gastrosplenic ligament in humans.
34486109	0	99	theme	nerve	85:89	arg1	presence					55:62	the presence	51:62	the presence of an apical splenic nerve in mice and humans	51:108	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans.
34486109	16	100	theme	phrenicosplenic	2354:2368	arg1	ligament					2370:2377	the phrenicosplenic ligament	2350:2377	the phrenicosplenic ligament	2350:2377	White nerve-like structures, which could represent the ASN, were macroscopically observed in the phrenicosplenic ligament in both mice and human and in the gastrosplenic ligament in humans.
34486109	2	101	theme	mouse	490:494	arg1	model					496:500	a mouse model	488:500	a mouse model of rheumatoid arthritis	488:524	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	0	102	from	study	42:46	arg1	presence					55:62	the presence	51:62	the presence of an apical splenic nerve in mice and humans	51:108	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans.
34486109	2	103	theme	splenic	346:352	arg1	acetylcholine					354:366	splenic acetylcholine	346:366	splenic acetylcholine	346:366	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	0	104	theme	comparative	2:12	arg1	study					42:46	A comparative anatomical and histological study	0:46	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans	0:108	A comparative anatomical and histological study on the presence of an apical splenic nerve in mice and humans.
34486109	14	105	theme	ligament	1952:1959	arg1	ligament					1901:1908	the gastrosplenic ligament	1883:1908	the gastrosplenic ligament	1883:1908	Since the gastrosplenic ligament was a continuation of the phrenicosplenic ligament, this ligament was explored as well and contained white, potential discrete nerve-like structures as well which could represent an ANS equivalent.
34486109	14	105	theme	ligament	1952:1959	arg1	continuation					1916:1927	a continuation	1914:1927	a continuation of the phrenicosplenic ligament	1914:1959	Since the gastrosplenic ligament was a continuation of the phrenicosplenic ligament, this ligament was explored as well and contained white, potential discrete nerve-like structures as well which could represent an ANS equivalent.
34486109	17	106	from	existence	2555:2563	arg1	human					2607:2611	human	2607:2611	human	2607:2611	The microscopic investigation did not confirm their neural identity and therefore, this study disclaims the existence of a parasympathetic ASN in both mice and human.
34486109	17	106	from	existence	2555:2563	arg1	mice					2598:2601	mice	2598:2601	mice	2598:2601	The microscopic investigation did not confirm their neural identity and therefore, this study disclaims the existence of a parasympathetic ASN in both mice and human.
34486109	2	107	theme	tumor	425:429	arg1	alpha					447:451	systemic tumor necrosis factor alpha	416:451	systemic tumor necrosis factor alpha	416:451	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	14	108	theme	discrete	2028:2035	arg1	structures					2048:2057	white, potential discrete nerve-like structures	2011:2057	white, potential discrete nerve-like structures	2011:2057	Since the gastrosplenic ligament was a continuation of the phrenicosplenic ligament, this ligament was explored as well and contained white, potential discrete nerve-like structures as well which could represent an ANS equivalent.
34486109	13	109	theme	phrenicosplenic	1760:1774	arg1	present					1789:1795	present	1789:1795	present	1789:1795	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	13	109	theme	phrenicosplenic	1760:1774	arg1	ligament					1776:1783	a phrenicosplenic ligament	1758:1783	a phrenicosplenic ligament	1758:1783	If a phrenicosplenic ligament was present in humans, a similar configuration of potential neural structures was observed.
34486109	1	110	theme	apical	252:257	arg1	ASN					274:276	ASN	274:276	ASN	274:276	The cranial pole of the mouse spleen is considered to be parasympathetically innervated by a macroscopic observable nerve referred to as the apical splenic nerve (ASN).
34486109	1	110	theme	apical	252:257	arg1	nerve					267:271	the apical splenic nerve	248:271	the apical splenic nerve (ASN)	248:277	The cranial pole of the mouse spleen is considered to be parasympathetically innervated by a macroscopic observable nerve referred to as the apical splenic nerve (ASN).
34486109	12	111	from	ligament	1690:1697	arg1	ASN					1607:1609	the ASN	1603:1609	the ASN	1603:1609	Macroscopically, the ASN could be clearly identified in all mice and was running in the phrenicosplenic ligament connecting the diaphragm and apical pole of the spleen.
34486109	12	111	from	ligament	1690:1697	arg1	running					1659:1665	running	1659:1665	running	1659:1665	Macroscopically, the ASN could be clearly identified in all mice and was running in the phrenicosplenic ligament connecting the diaphragm and apical pole of the spleen.
34486109	8	112	dep	ASN	1154:1156	arg1	both					1159:1162	both	1159:1162	both	1159:1162	Six mice and six human cadavers were used to study and compare the ASN, both macro- and microscopically.
34486109	8	112	dep	ASN	1154:1156	arg1	microscopically					1175:1189	microscopically	1175:1189	microscopically	1175:1189	Six mice and six human cadavers were used to study and compare the ASN, both macro- and microscopically.
34486109	2	113	theme	lipopolysaccharide-induced	379:404	arg1	levels					406:411	lipopolysaccharide-induced levels	379:411	lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha	379:451	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	4	114	theme	ASN	772:774	arg1	equivalent					776:785	a human ASN equivalent	764:785	a human ASN equivalent	764:785	So far, it is unknown if a human ASN equivalent exists.
34486109	11	115	theme	nerve	1526:1530	arg1	composition					1538:1548	nerve fiber composition	1526:1548	nerve fiber composition	1526:1548	Neural identity and nerve fiber composition was then evaluated microscopically.
34486109	12	116	theme	spleen	1747:1752	arg1	diaphragm					1714:1722	diaphragm	1714:1722	diaphragm	1714:1722	Macroscopically, the ASN could be clearly identified in all mice and was running in the phrenicosplenic ligament connecting the diaphragm and apical pole of the spleen.
34486109	12	116	theme	spleen	1747:1752	arg1	pole					1735:1738	apical pole	1728:1738	apical pole	1728:1738	Macroscopically, the ASN could be clearly identified in all mice and was running in the phrenicosplenic ligament connecting the diaphragm and apical pole of the spleen.
34486109	2	117	theme	factor	440:445	arg1	alpha					447:451	systemic tumor necrosis factor alpha	416:451	systemic tumor necrosis factor alpha	416:451	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	14	118	theme	gastrosplenic	1887:1899	arg1	ligament					1901:1908	the gastrosplenic ligament	1883:1908	the gastrosplenic ligament	1883:1908	Since the gastrosplenic ligament was a continuation of the phrenicosplenic ligament, this ligament was explored as well and contained white, potential discrete nerve-like structures as well which could represent an ANS equivalent.
34486109	14	118	theme	gastrosplenic	1887:1899	arg1	continuation					1916:1927	a continuation	1914:1927	a continuation of the phrenicosplenic ligament	1914:1959	Since the gastrosplenic ligament was a continuation of the phrenicosplenic ligament, this ligament was explored as well and contained white, potential discrete nerve-like structures as well which could represent an ANS equivalent.
34486109	10	119	theme	ASN	1312:1314	arg1	samples					1316:1322	ASN samples	1312:1322	ASN samples	1312:1322	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	2	120	theme	Electrical	280:289	arg1	stimulation					291:301	Electrical stimulation	280:301	Electrical stimulation of the ASN	280:312	Electrical stimulation of the ASN resulted in increased levels of splenic acetylcholine, decreased lipopolysaccharide-induced levels of systemic tumor necrosis factor alpha and mitigated clinical symptoms in a mouse model of rheumatoid arthritis.
34486109	12	121	theme	apical	1728:1733	arg1	pole					1735:1738	apical pole	1728:1738	apical pole	1728:1738	Macroscopically, the ASN could be clearly identified in all mice and was running in the phrenicosplenic ligament connecting the diaphragm and apical pole of the spleen.
34486109	10	122	theme	nerve	1478:1482	arg1	marker					1484:1489	a general, sympathetic and parasympathetic nerve marker	1435:1489	a general, sympathetic and parasympathetic nerve marker	1435:1489	ASN samples were resected, embedded in paraffin, cut in 5 μm thin sections where after adjacent sections were stained with a general, sympathetic and parasympathetic nerve marker, respectively.
34486109	3	123	theme	electrical	661:670	arg1	stimulation					672:682	electrical stimulation	661:682	a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases	630:736	If such a discrete ASN would be present in humans, this structure is of interest as it might represent a relatively easily accessible electrical stimulation target to treat immune-mediated inflammatory diseases.
34486109	1	124	theme	observable	216:225	arg1	nerve					227:231	a macroscopic observable nerve	202:231	a macroscopic observable nerve referred to as the apical splenic nerve (ASN)	202:277	The cranial pole of the mouse spleen is considered to be parasympathetically innervated by a macroscopic observable nerve referred to as the apical splenic nerve (ASN).
34515629	9	0	theme	related	910:916	arg1	species					984:990	species	984:990	species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %	984:1059	The closely related species of strain CTTWT based on the 16S rRNA gene sequences were species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %.
34515629	9	0	theme	related	910:916	arg1	species					918:924	The closely related species	898:924	The closely related species of strain CTTWT based on the 16S rRNA gene sequences	898:977	The closely related species of strain CTTWT based on the 16S rRNA gene sequences were species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %.
34515629	7	1	theme	utilized	760:767	arg1	substrates					769:778	the utilized substrates	756:778	the utilized substrates	756:778	The strain produced acetate, ethanol, H2 and CO2 as fermentation products from the utilized substrates.
34515629	3	2	with	rods	417:420	arg1	flagella					440:447	peritrichous flagella	427:447	peritrichous flagella	427:447	Cells of the strain were Gram-stain-positive, short rods with peritrichous flagella.
34515629	2	3	theme	bacterial	174:182	arg1	CTTWT					192:196	CTTWT	192:196	CTTWT	192:196	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	2	3	theme	bacterial	174:182	arg1	strain					184:189	An obligately anaerobic bacterial strain	150:189	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia	150:265	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	2	4	theme	soil	295:298	arg1	sample					300:305	an anoxic soil sample	285:305	an anoxic soil sample subjected to biological or reductive soil disinfestation	285:362	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	14	5	theme	genomic	1648:1654	arg1	analyses					1671:1678	the phylogenetic, genomic and phenotypic analyses	1630:1678	the phylogenetic, genomic and phenotypic analyses	1630:1678	Based on the phylogenetic, genomic and phenotypic analyses, the name Anaerocolumna chitinilytica sp.
34515629	9	6	theme	CTTWT	936:940	arg1	species					984:990	species	984:990	species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %	984:1059	The closely related species of strain CTTWT based on the 16S rRNA gene sequences were species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %.
34515629	9	6	theme	CTTWT	936:940	arg1	species					918:924	The closely related species	898:924	The closely related species of strain CTTWT based on the 16S rRNA gene sequences	898:977	The closely related species of strain CTTWT based on the 16S rRNA gene sequences were species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %.
34515629	13	7	theme	genomic	1546:1552	arg1	properties					1569:1578	the genomic and phenotypic properties	1542:1578	the genomic and phenotypic properties of strain CTTWT	1542:1594	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	13	7	theme	genomic	1546:1552	arg1	distinct					1601:1608	distinct	1601:1608	distinct	1601:1608	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	13	8	theme	related	1507:1513	arg1	species					1529:1535	the related Anaerocolumna species	1503:1535	the related Anaerocolumna species	1503:1535	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	9	9	theme	16S	955:957	arg1	sequences					969:977	the 16S rRNA gene sequences	951:977	the 16S rRNA gene sequences	951:977	The closely related species of strain CTTWT based on the 16S rRNA gene sequences were species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %.
34515629	13	10	theme	species	1529:1535	arg1	genomes					1492:1498	the genomes	1488:1498	the genomes of the related Anaerocolumna species	1488:1535	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	9	11	theme	gene	964:967	arg1	sequences					969:977	the 16S rRNA gene sequences	951:977	the 16S rRNA gene sequences	951:977	The closely related species of strain CTTWT based on the 16S rRNA gene sequences were species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %.
34515629	14	12	theme	phenotypic	1660:1669	arg1	analyses					1671:1678	the phylogenetic, genomic and phenotypic analyses	1630:1678	the phylogenetic, genomic and phenotypic analyses	1630:1678	Based on the phylogenetic, genomic and phenotypic analyses, the name Anaerocolumna chitinilytica sp.
34515629	13	13	located	found	1479:1483	arg2	genes					1444:1448	Homologous genes	1433:1448	Homologous genes encoding these proteins	1433:1472	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	13	13	located	found	1479:1483	arg1	genomes					1492:1498	the genomes	1488:1498	the genomes of the related Anaerocolumna species	1488:1535	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	7	14	from	substrates	769:778	arg1	products					742:749	fermentation products	729:749	fermentation products from the utilized substrates	729:778	The strain produced acetate, ethanol, H2 and CO2 as fermentation products from the utilized substrates.
34515629	8	15	theme	major	785:789	arg1	acids					806:810	The major cellular fatty acids	781:810	The major cellular fatty acids of the strain	781:824	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	8	15	theme	major	785:789	arg1	C16 					831:834	C16 	831:834	C16 	831:834	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	15	16	from	nov.	1722:1725	arg1	Lachnospiraceae					1742:1756	the family Lachnospiraceae	1731:1756	the family Lachnospiraceae	1731:1756	nov., in the family Lachnospiraceae is proposed for strain CTTWT (=NBRC 112102T=DSM 110036T).
34515629	1	17	theme	soil	129:132	arg1	disinfestation					134:147	biological soil disinfestation	118:147	biological soil disinfestation	118:147	nov., a chitin-decomposing anaerobic bacterium isolated from anoxic soil subjected to biological soil disinfestation.
34515629	8	18	theme	 1 ω7c	836:841	arg1	dimethylacetal					843:856	 1 ω7c dimethylacetal	836:856	 1 ω7c dimethylacetal (DMA)	836:862	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	8	18	theme	 1 ω7c	836:841	arg1	DMA					859:861	DMA	859:861	DMA	859:861	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	8	19	theme	fatty	800:804	arg1	acids					806:810	The major cellular fatty acids	781:810	The major cellular fatty acids of the strain	781:824	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	8	19	theme	fatty	800:804	arg1	C16 					831:834	C16 	831:834	C16 	831:834	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	10	20	theme	DNA	1178:1180	arg1	content					1186:1192	the genomic DNA G+C content	1166:1192	the genomic DNA G+C content	1166:1192	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	10	20	theme	DNA	1178:1180	arg1	%					1206:1206	38.3 mol%	1198:1206	38.3 mol%	1198:1206	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	5	21	theme	cell	567:570	arg1	biomass					572:578	cell biomass	567:578	cell biomass	567:578	Strain CTTWT decomposed cell biomass and cell-wall preparations of an ascomycete plant pathogen, Fusarium oxysporum f. sp.
34515629	11	22	with	genes	1222:1226	arg1	sequences					1248:1256	five different sequences	1233:1256	five different sequences from each other	1233:1272	Six 16S rRNA genes with five different sequences from each other were found in the genome.
34515629	8	23	theme	strain	819:824	arg1	acids					806:810	The major cellular fatty acids	781:810	The major cellular fatty acids of the strain	781:824	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	8	23	theme	strain	819:824	arg1	C16 					831:834	C16 	831:834	C16 	831:834	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	9	24	with	Anaerocolumna	1005:1017	arg1	similarities					1033:1044	sequence similarities	1024:1044	sequence similarities of 95.2-97.6 %	1024:1059	The closely related species of strain CTTWT based on the 16S rRNA gene sequences were species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %.
34515629	11	25	theme	16S	1213:1215	arg1	genes					1222:1226	Six 16S rRNA genes	1209:1226	Six 16S rRNA genes with five different sequences from each other	1209:1272	Six 16S rRNA genes with five different sequences from each other were found in the genome.
34515629	10	26	theme	38.3 mol	1198:1205	arg1	content					1186:1192	the genomic DNA G+C content	1166:1192	the genomic DNA G+C content	1166:1192	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	10	26	theme	38.3 mol	1198:1205	arg1	%					1206:1206	38.3 mol%	1198:1206	38.3 mol%	1198:1206	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	10	27	theme	analyses	1080:1087	arg1	Results					1062:1068	Results	1062:1068	Results of genome analyses of strain CTTWT	1062:1103	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	8	28	theme	 0	870:871	arg1	DMA					873:875	 0 DMA	870:875	 0 DMA	870:875	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	15	29	theme	family	1735:1740	arg1	Lachnospiraceae					1742:1756	the family Lachnospiraceae	1731:1756	the family Lachnospiraceae	1731:1756	nov., in the family Lachnospiraceae is proposed for strain CTTWT (=NBRC 112102T=DSM 110036T).
34515629	0	30	theme	Anaerocolumna	0:12	arg1	sp					28:29	Anaerocolumna chitinilytica sp	0:29	Anaerocolumna chitinilytica sp.	0:30	Anaerocolumna chitinilytica sp.
34515629	5	31	theme	plant	624:628	arg1	pathogen					630:637	an ascomycete plant pathogen	610:637	an ascomycete plant pathogen	610:637	Strain CTTWT decomposed cell biomass and cell-wall preparations of an ascomycete plant pathogen, Fusarium oxysporum f. sp.
34515629	13	32	theme	strain	1583:1588	arg1	CTTWT					1590:1594	strain CTTWT	1583:1594	strain CTTWT	1583:1594	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	9	33	from	species	984:990	arg1	Anaerocolumna					1005:1017	the genus Anaerocolumna	995:1017	the genus Anaerocolumna with sequence similarities of 95.2-97.6 %	995:1059	The closely related species of strain CTTWT based on the 16S rRNA gene sequences were species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %.
34515629	10	34	theme	strain	1092:1097	arg1	CTTWT					1099:1103	strain CTTWT	1092:1103	strain CTTWT	1092:1103	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	3	35	theme	peritrichous	427:438	arg1	flagella					440:447	peritrichous flagella	427:447	peritrichous flagella	427:447	Cells of the strain were Gram-stain-positive, short rods with peritrichous flagella.
34515629	9	36	theme	genus	999:1003	arg1	Anaerocolumna					1005:1017	the genus Anaerocolumna	995:1017	the genus Anaerocolumna with sequence similarities of 95.2-97.6 %	995:1059	The closely related species of strain CTTWT based on the 16S rRNA gene sequences were species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %.
34515629	2	37	theme	soil	344:347	arg1	disinfestation					349:362	biological or reductive soil disinfestation	320:362	biological or reductive soil disinfestation	320:362	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	14	38	theme	Anaerocolumna	1690:1702	arg1	sp					1718:1719	the name Anaerocolumna chitinilytica sp	1681:1719	the name Anaerocolumna chitinilytica sp	1681:1719	Based on the phylogenetic, genomic and phenotypic analyses, the name Anaerocolumna chitinilytica sp.
34515629	12	39	contain	had	1313:1315	arg2	genes					1317:1321	genes	1317:1321	genes encoding chitinase, xylanase, cellulase, β-glucosidase and nitrogenase as characteristic genes in the genome	1317:1430	Strain CTTWT had genes encoding chitinase, xylanase, cellulase, β-glucosidase and nitrogenase as characteristic genes in the genome.
34515629	12	39	contain	had	1313:1315	arg1	CTTWT					1307:1311	Strain CTTWT	1300:1311	Strain CTTWT	1300:1311	Strain CTTWT had genes encoding chitinase, xylanase, cellulase, β-glucosidase and nitrogenase as characteristic genes in the genome.
34515629	8	40	dep	C16 	831:834	arg1	DMA					873:875	 0 DMA	870:875	 0 DMA	870:875	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	8	40	dep	C16 	831:834	arg1	dimethylacetal					843:856	 1 ω7c dimethylacetal	836:856	 1 ω7c dimethylacetal (DMA)	836:862	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	8	40	dep	C16 	831:834	arg1	DMA					859:861	DMA	859:861	DMA	859:861	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	8	40	dep	C16 	831:834	arg1	C18 					881:884	C18 	881:884	C18 	881:884	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	8	40	dep	C16 	831:834	arg1	DMA					893:895	 1 ω7c DMA	886:895	 1 ω7c DMA	886:895	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	1	41	theme	chitin-decomposing	40:57	arg1	bacterium					69:77	a chitin-decomposing anaerobic bacterium	38:77	a chitin-decomposing anaerobic bacterium	38:77	nov., a chitin-decomposing anaerobic bacterium isolated from anoxic soil subjected to biological soil disinfestation.
34515629	1	41	theme	chitin-decomposing	40:57	arg1	nov.					32:35	nov.	32:35	nov.	32:35	nov., a chitin-decomposing anaerobic bacterium isolated from anoxic soil subjected to biological soil disinfestation.
34515629	15	42	theme	strain	1774:1779	arg1	CTTWT					1781:1785	strain CTTWT	1774:1785	strain CTTWT (=NBRC 112102T=DSM 110036T)	1774:1813	nov., in the family Lachnospiraceae is proposed for strain CTTWT (=NBRC 112102T=DSM 110036T).
34515629	15	42	theme	strain	1774:1779	arg1	110036T					1806:1812	=NBRC 112102T=DSM 110036T	1788:1812	=NBRC 112102T=DSM 110036T	1788:1812	nov., in the family Lachnospiraceae is proposed for strain CTTWT (=NBRC 112102T=DSM 110036T).
34515629	10	43	theme	genomic	1170:1176	arg1	content					1186:1192	the genomic DNA G+C content	1166:1192	the genomic DNA G+C content	1166:1192	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	10	43	theme	genomic	1170:1176	arg1	%					1206:1206	38.3 mol%	1198:1206	38.3 mol%	1198:1206	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	12	44	theme	characteristic	1397:1410	arg1	genes					1412:1416	characteristic genes	1397:1416	characteristic genes in the genome	1397:1430	Strain CTTWT had genes encoding chitinase, xylanase, cellulase, β-glucosidase and nitrogenase as characteristic genes in the genome.
34515629	5	45	dep	preparations	594:605	arg1	sp					662:663	f. sp	659:663	f. sp	659:663	Strain CTTWT decomposed cell biomass and cell-wall preparations of an ascomycete plant pathogen, Fusarium oxysporum f. sp.
34515629	9	46	theme	strain	929:934	arg1	CTTWT					936:940	strain CTTWT	929:940	strain CTTWT	929:940	The closely related species of strain CTTWT based on the 16S rRNA gene sequences were species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %.
34515629	2	47	theme	anaerobic	164:172	arg1	CTTWT					192:196	CTTWT	192:196	CTTWT	192:196	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	2	47	theme	anaerobic	164:172	arg1	strain					184:189	An obligately anaerobic bacterial strain	150:189	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia	150:265	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	2	48	theme	anoxic	288:293	arg1	sample					300:305	an anoxic soil sample	285:305	an anoxic soil sample subjected to biological or reductive soil disinfestation	285:362	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	11	49	located	found	1279:1283	arg1	genome					1292:1297	the genome	1288:1297	the genome	1288:1297	Six 16S rRNA genes with five different sequences from each other were found in the genome.
34515629	11	49	located	found	1279:1283	arg2	genes					1222:1226	Six 16S rRNA genes	1209:1226	Six 16S rRNA genes with five different sequences from each other	1209:1272	Six 16S rRNA genes with five different sequences from each other were found in the genome.
34515629	5	50	theme	Strain	543:548	arg1	CTTWT					550:554	Strain CTTWT	543:554	Strain CTTWT	543:554	Strain CTTWT decomposed cell biomass and cell-wall preparations of an ascomycete plant pathogen, Fusarium oxysporum f. sp.
34515629	12	51	theme	Strain	1300:1305	arg1	CTTWT					1307:1311	Strain CTTWT	1300:1311	Strain CTTWT	1300:1311	Strain CTTWT had genes encoding chitinase, xylanase, cellulase, β-glucosidase and nitrogenase as characteristic genes in the genome.
34515629	13	52	theme	Anaerocolumna	1515:1527	arg1	species					1529:1535	the related Anaerocolumna species	1503:1535	the related Anaerocolumna species	1503:1535	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	2	53	theme	biological	320:329	arg1	disinfestation					349:362	biological or reductive soil disinfestation	320:362	biological or reductive soil disinfestation	320:362	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	9	54	theme	rRNA	959:962	arg1	sequences					969:977	the 16S rRNA gene sequences	951:977	the 16S rRNA gene sequences	951:977	The closely related species of strain CTTWT based on the 16S rRNA gene sequences were species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %.
34515629	14	55	theme	phylogenetic	1634:1645	arg1	analyses					1671:1678	the phylogenetic, genomic and phenotypic analyses	1630:1678	the phylogenetic, genomic and phenotypic analyses	1630:1678	Based on the phylogenetic, genomic and phenotypic analyses, the name Anaerocolumna chitinilytica sp.
34515629	2	56	theme	class	250:254	arg1	Clostridia					256:265	the class Clostridia	246:265	the class Clostridia	246:265	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	15	57	theme	112102T=DSM	1794:1804	arg1	CTTWT					1781:1785	strain CTTWT	1774:1785	strain CTTWT (=NBRC 112102T=DSM 110036T)	1774:1813	nov., in the family Lachnospiraceae is proposed for strain CTTWT (=NBRC 112102T=DSM 110036T).
34515629	15	57	theme	112102T=DSM	1794:1804	arg1	110036T					1806:1812	=NBRC 112102T=DSM 110036T	1788:1812	=NBRC 112102T=DSM 110036T	1788:1812	nov., in the family Lachnospiraceae is proposed for strain CTTWT (=NBRC 112102T=DSM 110036T).
34515629	5	58	theme	cell-wall	584:592	arg1	preparations					594:605	cell-wall preparations	584:605	cell-wall preparations of an ascomycete plant pathogen	584:637	Strain CTTWT decomposed cell biomass and cell-wall preparations of an ascomycete plant pathogen, Fusarium oxysporum f. sp.
34515629	1	59	theme	biological	118:127	arg1	disinfestation					134:147	biological soil disinfestation	118:147	biological soil disinfestation	118:147	nov., a chitin-decomposing anaerobic bacterium isolated from anoxic soil subjected to biological soil disinfestation.
34515629	12	60	from	genes	1412:1416	arg1	genome					1425:1430	the genome	1421:1430	the genome	1421:1430	Strain CTTWT had genes encoding chitinase, xylanase, cellulase, β-glucosidase and nitrogenase as characteristic genes in the genome.
34515629	2	61	attach	isolated	271:278	arg2	strain					184:189	An obligately anaerobic bacterial strain	150:189	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia	150:265	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	2	61	attach	isolated	271:278	arg1	sample					300:305	an anoxic soil sample	285:305	an anoxic soil sample subjected to biological or reductive soil disinfestation	285:362	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	2	61	attach	isolated	271:278	arg2	CTTWT					192:196	CTTWT	192:196	CTTWT	192:196	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	10	62	theme	G+C	1182:1184	arg1	content					1186:1192	the genomic DNA G+C content	1166:1192	the genomic DNA G+C content	1166:1192	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	10	62	theme	G+C	1182:1184	arg1	%					1206:1206	38.3 mol%	1198:1206	38.3 mol%	1198:1206	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	8	63	theme	cellular	791:798	arg1	acids					806:810	The major cellular fatty acids	781:810	The major cellular fatty acids of the strain	781:824	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	8	63	theme	cellular	791:798	arg1	C16 					831:834	C16 	831:834	C16 	831:834	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	3	64	dep	Gram-stain-positive	390:408	arg1	short					411:415	short	411:415	short	411:415	Cells of the strain were Gram-stain-positive, short rods with peritrichous flagella.
34515629	9	65	theme	sequence	1024:1031	arg1	similarities					1033:1044	sequence similarities	1024:1044	sequence similarities of 95.2-97.6 %	1024:1059	The closely related species of strain CTTWT based on the 16S rRNA gene sequences were species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %.
34515629	1	66	theme	anaerobic	59:67	arg1	bacterium					69:77	a chitin-decomposing anaerobic bacterium	38:77	a chitin-decomposing anaerobic bacterium	38:77	nov., a chitin-decomposing anaerobic bacterium isolated from anoxic soil subjected to biological soil disinfestation.
34515629	1	66	theme	anaerobic	59:67	arg1	nov.					32:35	nov.	32:35	nov.	32:35	nov., a chitin-decomposing anaerobic bacterium isolated from anoxic soil subjected to biological soil disinfestation.
34515629	3	67	theme	strain	378:383	arg1	Cells					365:369	Cells	365:369	Cells of the strain	365:383	Cells of the strain were Gram-stain-positive, short rods with peritrichous flagella.
34515629	11	68	theme	rRNA	1217:1220	arg1	genes					1222:1226	Six 16S rRNA genes	1209:1226	Six 16S rRNA genes with five different sequences from each other	1209:1272	Six 16S rRNA genes with five different sequences from each other were found in the genome.
34515629	10	69	theme	genome	1073:1078	arg1	analyses					1080:1087	genome analyses	1073:1087	genome analyses of strain CTTWT	1073:1103	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	5	70	theme	f.	659:660	arg1	sp					662:663	f. sp	659:663	f. sp	659:663	Strain CTTWT decomposed cell biomass and cell-wall preparations of an ascomycete plant pathogen, Fusarium oxysporum f. sp.
34515629	14	71	theme	name	1685:1688	arg1	sp					1718:1719	the name Anaerocolumna chitinilytica sp	1681:1719	the name Anaerocolumna chitinilytica sp	1681:1719	Based on the phylogenetic, genomic and phenotypic analyses, the name Anaerocolumna chitinilytica sp.
34515629	9	72	theme	%	1059:1059	arg1	similarities					1033:1044	sequence similarities	1024:1044	sequence similarities of 95.2-97.6 %	1024:1059	The closely related species of strain CTTWT based on the 16S rRNA gene sequences were species in the genus Anaerocolumna with sequence similarities of 95.2-97.6 %.
34515629	13	73	theme	Homologous	1433:1442	arg1	genes					1444:1448	Homologous genes	1433:1448	Homologous genes encoding these proteins	1433:1472	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	0	74	theme	chitinilytica	14:26	arg1	sp					28:29	Anaerocolumna chitinilytica sp	0:29	Anaerocolumna chitinilytica sp.	0:30	Anaerocolumna chitinilytica sp.
34515629	5	75	theme	ascomycete	613:622	arg1	pathogen					630:637	an ascomycete plant pathogen	610:637	an ascomycete plant pathogen	610:637	Strain CTTWT decomposed cell biomass and cell-wall preparations of an ascomycete plant pathogen, Fusarium oxysporum f. sp.
34515629	1	76	theme	anoxic	93:98	arg1	soil					100:103	anoxic soil	93:103	anoxic soil subjected to biological soil disinfestation	93:147	nov., a chitin-decomposing anaerobic bacterium isolated from anoxic soil subjected to biological soil disinfestation.
34515629	11	77	from	other	1268:1272	arg1	sequences					1248:1256	five different sequences	1233:1256	five different sequences from each other	1233:1272	Six 16S rRNA genes with five different sequences from each other were found in the genome.
34515629	11	78	theme	different	1238:1246	arg1	sequences					1248:1256	five different sequences	1233:1256	five different sequences from each other	1233:1272	Six 16S rRNA genes with five different sequences from each other were found in the genome.
34515629	7	79	theme	fermentation	729:740	arg1	products					742:749	fermentation products	729:749	fermentation products from the utilized substrates	729:778	The strain produced acetate, ethanol, H2 and CO2 as fermentation products from the utilized substrates.
34515629	10	80	theme	CTTWT	1099:1103	arg1	analyses					1080:1087	genome analyses	1073:1087	genome analyses of strain CTTWT	1073:1103	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	5	81	theme	pathogen	630:637	arg1	biomass					572:578	cell biomass	567:578	cell biomass	567:578	Strain CTTWT decomposed cell biomass and cell-wall preparations of an ascomycete plant pathogen, Fusarium oxysporum f. sp.
34515629	5	81	theme	pathogen	630:637	arg1	preparations					594:605	cell-wall preparations	584:605	cell-wall preparations of an ascomycete plant pathogen	584:637	Strain CTTWT decomposed cell biomass and cell-wall preparations of an ascomycete plant pathogen, Fusarium oxysporum f. sp.
34515629	3	82	theme	Gram-stain-positive	390:408	arg1	rods					417:420	Gram-stain-positive, short rods	390:420	Gram-stain-positive, short rods with peritrichous flagella	390:447	Cells of the strain were Gram-stain-positive, short rods with peritrichous flagella.
34515629	13	83	theme	CTTWT	1590:1594	arg1	properties					1569:1578	the genomic and phenotypic properties	1542:1578	the genomic and phenotypic properties of strain CTTWT	1542:1594	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	13	83	theme	CTTWT	1590:1594	arg1	distinct					1601:1608	distinct	1601:1608	distinct	1601:1608	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	13	84	from	them	1615:1618	arg1	properties					1569:1578	the genomic and phenotypic properties	1542:1578	the genomic and phenotypic properties of strain CTTWT	1542:1594	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	13	84	from	them	1615:1618	arg1	distinct					1601:1608	distinct	1601:1608	distinct	1601:1608	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	8	85	theme	 1 ω7c	886:891	arg1	DMA					893:895	 1 ω7c DMA	886:895	 1 ω7c DMA	886:895	The major cellular fatty acids of the strain were C16 : 1 ω7c dimethylacetal (DMA), C16 : 0 DMA and C18 : 1 ω7c DMA.
34515629	10	86	theme	genome	1124:1129	arg1	5.62 Mb					1154:1160	5.62 Mb	1154:1160	5.62 Mb	1154:1160	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	10	86	theme	genome	1124:1129	arg1	size					1131:1134	the genome size	1120:1134	the genome size of the strain	1120:1148	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	13	87	theme	phenotypic	1558:1567	arg1	properties					1569:1578	the genomic and phenotypic properties	1542:1578	the genomic and phenotypic properties of strain CTTWT	1542:1594	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	13	87	theme	phenotypic	1558:1567	arg1	distinct					1601:1608	distinct	1601:1608	distinct	1601:1608	Homologous genes encoding these proteins were found in the genomes of the related Anaerocolumna species, but the genomic and phenotypic properties of strain CTTWT were distinct from them.
34515629	2	88	theme	family	216:221	arg1	Lachnospiraceae					223:237	the family Lachnospiraceae	212:237	the family Lachnospiraceae within the class Clostridia	212:265	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	14	89	theme	chitinilytica	1704:1716	arg1	sp					1718:1719	the name Anaerocolumna chitinilytica sp	1681:1719	the name Anaerocolumna chitinilytica sp	1681:1719	Based on the phylogenetic, genomic and phenotypic analyses, the name Anaerocolumna chitinilytica sp.
34515629	2	90	theme	reductive	334:342	arg1	disinfestation					349:362	biological or reductive soil disinfestation	320:362	biological or reductive soil disinfestation	320:362	An obligately anaerobic bacterial strain (CTTWT) belonging to the family Lachnospiraceae within the class Clostridia was isolated from an anoxic soil sample subjected to biological or reductive soil disinfestation.
34515629	10	91	theme	strain	1143:1148	arg1	5.62 Mb					1154:1160	5.62 Mb	1154:1160	5.62 Mb	1154:1160	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	10	91	theme	strain	1143:1148	arg1	size					1131:1134	the genome size	1120:1134	the genome size of the strain	1120:1148	Results of genome analyses of strain CTTWT indicated that the genome size of the strain was 5.62 Mb and the genomic DNA G+C content was 38.3 mol%.
34515629	15	92	theme	=NBRC	1788:1792	arg1	CTTWT					1781:1785	strain CTTWT	1774:1785	strain CTTWT (=NBRC 112102T=DSM 110036T)	1774:1813	nov., in the family Lachnospiraceae is proposed for strain CTTWT (=NBRC 112102T=DSM 110036T).
34515629	15	92	theme	=NBRC	1788:1792	arg1	110036T					1806:1812	=NBRC 112102T=DSM 110036T	1788:1812	=NBRC 112102T=DSM 110036T	1788:1812	nov., in the family Lachnospiraceae is proposed for strain CTTWT (=NBRC 112102T=DSM 110036T).
31915220	10	0	theme	recognition	2012:2022	arg1	mechanisms					1988:1997	the mechanisms	1984:1997	the mechanisms of prebiotic recognition and transport by gut bacteria	1984:2052	However, little is currently known about the mechanisms of prebiotic recognition and transport by gut bacteria, while these steps are crucial in their metabolism.
31915220	13	1	theme	pathology	2672:2680	arg1	biomarker					2646:2654	a biomarker	2644:2654	a biomarker of diet and gut pathology	2644:2680	Based on these developments, we identified and characterized, at the molecular level, a fructooligosaccharide transporting phosphotransferase system, which constitutes a biomarker of diet and gut pathology.
31915220	11	2	theme	transporters	2197:2208	arg1	specificity					2166:2176	the specificity	2162:2176	the specificity of oligosaccharide transporters	2162:2208	In this study, we established a new strategy to profile the specificity of oligosaccharide transporters, combining microbiomics, genetic locus and strain engineering, and state-of-the art metabolomics.
31915220	6	3	theme	binding	1241:1247	arg1	engineering					1203:1213	carbohydrate utilization locus and host genome engineering	1156:1213	engineering	1203:1213	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	6	3	theme	binding	1241:1247	arg1	rates					1272:1276	growth rates	1265:1276	growth rates	1265:1276	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	6	3	theme	binding	1241:1247	arg1	locus					1181:1185	carbohydrate utilization locus and host genome engineering	1156:1213	locus	1181:1185	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	6	3	theme	binding	1241:1247	arg1	transport					1250:1258	transport	1250:1258	transport	1250:1258	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	6	3	theme	binding	1241:1247	arg1	quantification					1219:1232	quantification	1219:1232	quantification	1219:1232	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	6	4	theme	mass	1327:1330	arg1	spectrometry					1332:1343	mass spectrometry	1327:1343	mass spectrometry	1327:1343	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	3	5	theme	carbohydrate	604:615	arg1	transport					629:637	transport	629:637	transport	629:637	Moreover, because of the difficulties of functionally profiling transmembrane proteins, only a few prebiotic transporters have been biochemically characterized to date, while carbohydrate binding and transport are the first and thus crucial steps in their metabolization.
31915220	3	5	theme	carbohydrate	604:615	arg1	first					647:651	first	647:651	first	647:651	Moreover, because of the difficulties of functionally profiling transmembrane proteins, only a few prebiotic transporters have been biochemically characterized to date, while carbohydrate binding and transport are the first and thus crucial steps in their metabolization.
31915220	3	5	theme	carbohydrate	604:615	arg1	binding					617:623	carbohydrate binding	604:623	carbohydrate binding	604:623	Moreover, because of the difficulties of functionally profiling transmembrane proteins, only a few prebiotic transporters have been biochemically characterized to date, while carbohydrate binding and transport are the first and thus crucial steps in their metabolization.
31915220	7	6	theme	fructooligosaccharide	1377:1397	arg1	transporter					1399:1409	the Dorea fructooligosaccharide transporter	1367:1409	the Dorea fructooligosaccharide transporter	1367:1409	We demonstrated that the Dorea fructooligosaccharide transporter is specific for kestose, whether for binding, transport, or phosphorylation.
31915220	7	6	theme	fructooligosaccharide	1377:1397	arg1	specific					1414:1421	specific	1414:1421	specific	1414:1421	We demonstrated that the Dorea fructooligosaccharide transporter is specific for kestose, whether for binding, transport, or phosphorylation.
31915220	10	7	theme	gut	2041:2043	arg1	bacteria					2045:2052	gut bacteria	2041:2052	gut bacteria	2041:2052	However, little is currently known about the mechanisms of prebiotic recognition and transport by gut bacteria, while these steps are crucial in their metabolism.
31915220	6	8	theme	carbohydrates	1310:1322	arg1	analysis					1283:1290	analysis	1283:1290	analysis of phosphorylated carbohydrates by mass spectrometry	1283:1343	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	9	9	theme	transporters.IMPORTANCE	1773:1795	arg1	supplements					1838:1848	food supplements	1833:1848	food supplements	1833:1848	Based on these new findings, we revisited the classification of these carbohydrate transporters.IMPORTANCE Prebiotics are increasingly used as food supplements, especially in infant formulas, to modify the functioning and composition of the microbiota.
31915220	9	9	theme	transporters.IMPORTANCE	1773:1795	arg1	Prebiotics					1797:1806	these carbohydrate transporters.IMPORTANCE Prebiotics	1754:1806	these carbohydrate transporters.IMPORTANCE Prebiotics	1754:1806	Based on these new findings, we revisited the classification of these carbohydrate transporters.IMPORTANCE Prebiotics are increasingly used as food supplements, especially in infant formulas, to modify the functioning and composition of the microbiota.
31915220	13	10	theme	transporting	2586:2597	arg1	system					2618:2623	a fructooligosaccharide transporting phosphotransferase system	2562:2623	a fructooligosaccharide transporting phosphotransferase system	2562:2623	Based on these developments, we identified and characterized, at the molecular level, a fructooligosaccharide transporting phosphotransferase system, which constitutes a biomarker of diet and gut pathology.
31915220	4	11	theme	molecular	723:731	arg1	mechanism					733:741	the molecular mechanism	719:741	the molecular mechanism of a phosphotransferase system, highlighted as a dietary and pathology biomarker in the human gut microbiome	719:850	Here, we describe the molecular mechanism of a phosphotransferase system, highlighted as a dietary and pathology biomarker in the human gut microbiome.
31915220	6	12	theme	genome	1196:1201	arg1	engineering					1203:1213	carbohydrate utilization locus and host genome engineering	1156:1213	engineering	1203:1213	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	5	13	theme	metagenomic	886:896	arg1	locus					898:902	a metagenomic locus	884:902	a metagenomic locus that is highly conserved in several human gut Firmicutes, including Dorea species	884:984	This transporter is encoded by a metagenomic locus that is highly conserved in several human gut Firmicutes, including Dorea species.
31915220	6	14	theme	generic	1002:1008	arg1	strategy					1010:1017	a generic strategy	1000:1017	a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry	1000:1343	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	11	15	theme	new	2138:2140	arg1	strategy					2142:2149	a new strategy	2136:2149	a new strategy to profile the specificity of oligosaccharide transporters, combining microbiomics, genetic locus and strain engineering, and state-of-the art metabolomics	2136:2305	In this study, we established a new strategy to profile the specificity of oligosaccharide transporters, combining microbiomics, genetic locus and strain engineering, and state-of-the art metabolomics.
31915220	2	16	theme	carbohydrate	245:256	arg1	analyses					270:277	carbohydrate utilization analyses	245:277	carbohydrate utilization analyses	245:277	However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metabolize these functional foods.
31915220	9	17	theme	food	1833:1836	arg1	supplements					1838:1848	food supplements	1833:1848	food supplements	1833:1848	Based on these new findings, we revisited the classification of these carbohydrate transporters.IMPORTANCE Prebiotics are increasingly used as food supplements, especially in infant formulas, to modify the functioning and composition of the microbiota.
31915220	9	17	theme	food	1833:1836	arg1	Prebiotics					1797:1806	these carbohydrate transporters.IMPORTANCE Prebiotics	1754:1806	these carbohydrate transporters.IMPORTANCE Prebiotics	1754:1806	Based on these new findings, we revisited the classification of these carbohydrate transporters.IMPORTANCE Prebiotics are increasingly used as food supplements, especially in infant formulas, to modify the functioning and composition of the microbiota.
31915220	8	18	theme	effective	1530:1538	arg1	phosphorylation					1540:1554	effective phosphorylation	1530:1554	effective phosphorylation of glycosides	1530:1568	This constitutes the biochemical proof of effective phosphorylation of glycosides with a degree of polymerization of more than 2, extending the known functional diversity of phosphotransferase systems.
31915220	9	19	dep	functioning	1896:1906	arg1	the					1892:1894	the	1892:1894	the	1892:1894	Based on these new findings, we revisited the classification of these carbohydrate transporters.IMPORTANCE Prebiotics are increasingly used as food supplements, especially in infant formulas, to modify the functioning and composition of the microbiota.
31915220	14	20	theme	nonbeneficial	2747:2759	arg1	bacterium					2761:2769	a nonbeneficial bacterium	2745:2769	a nonbeneficial bacterium	2745:2769	The deciphering of this prebiotic metabolization mechanism by a nonbeneficial bacterium highlights the controversial use of prebiotics, especially in the context of chronic gut diseases.
31915220	4	21	theme	pathology	804:812	arg1	biomarker					814:822	a dietary and pathology biomarker	790:822	biomarker	814:822	Here, we describe the molecular mechanism of a phosphotransferase system, highlighted as a dietary and pathology biomarker in the human gut microbiome.
31915220	2	22	theme	metagenomic	283:293	arg1	studies					295:301	metagenomic studies	283:301	metagenomic studies	283:301	However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metabolize these functional foods.
31915220	5	23	theme	human	940:944	arg1	Firmicutes					950:959	several human gut Firmicutes	932:959	several human gut Firmicutes	932:959	This transporter is encoded by a metagenomic locus that is highly conserved in several human gut Firmicutes, including Dorea species.
31915220	5	23	theme	human	940:944	arg1	species					978:984	Dorea species	972:984	Dorea species	972:984	This transporter is encoded by a metagenomic locus that is highly conserved in several human gut Firmicutes, including Dorea species.
31915220	14	24	theme	metabolization	2717:2730	arg1	mechanism					2732:2740	this prebiotic metabolization mechanism	2702:2740	this prebiotic metabolization mechanism	2702:2740	The deciphering of this prebiotic metabolization mechanism by a nonbeneficial bacterium highlights the controversial use of prebiotics, especially in the context of chronic gut diseases.
31915220	4	25	theme	phosphotransferase	748:765	arg1	system					767:772	a phosphotransferase system	746:772	a phosphotransferase system	746:772	Here, we describe the molecular mechanism of a phosphotransferase system, highlighted as a dietary and pathology biomarker in the human gut microbiome.
31915220	8	26	theme	polymerization	1587:1600	arg1	degree					1577:1582	a degree	1575:1582	a degree of polymerization of more than 2	1575:1615	This constitutes the biochemical proof of effective phosphorylation of glycosides with a degree of polymerization of more than 2, extending the known functional diversity of phosphotransferase systems.
31915220	6	27	dep	specificity	1067:1077	arg1	the					1063:1065	the	1063:1065	the	1063:1065	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	8	28	theme	more	1605:1608	arg1	polymerization					1587:1600	polymerization	1587:1600	polymerization of more than 2	1587:1615	This constitutes the biochemical proof of effective phosphorylation of glycosides with a degree of polymerization of more than 2, extending the known functional diversity of phosphotransferase systems.
31915220	4	29	theme	human	831:835	arg1	microbiome					841:850	the human gut microbiome	827:850	the human gut microbiome	827:850	Here, we describe the molecular mechanism of a phosphotransferase system, highlighted as a dietary and pathology biomarker in the human gut microbiome.
31915220	3	30	from	steps	670:674	arg1	metabolization					685:698	their metabolization	679:698	their metabolization	679:698	Moreover, because of the difficulties of functionally profiling transmembrane proteins, only a few prebiotic transporters have been biochemically characterized to date, while carbohydrate binding and transport are the first and thus crucial steps in their metabolization.
31915220	3	31	theme	profiling	483:491	arg1	proteins					507:514	functionally profiling transmembrane proteins	470:514	functionally profiling transmembrane proteins	470:514	Moreover, because of the difficulties of functionally profiling transmembrane proteins, only a few prebiotic transporters have been biochemically characterized to date, while carbohydrate binding and transport are the first and thus crucial steps in their metabolization.
31915220	10	32	from	crucial	2077:2083	arg1	metabolism					2094:2103	their metabolism	2088:2103	their metabolism	2088:2103	However, little is currently known about the mechanisms of prebiotic recognition and transport by gut bacteria, while these steps are crucial in their metabolism.
31915220	6	33	theme	transporters	1112:1123	arg1	functionality					1083:1095	functionality	1083:1095	functionality	1083:1095	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	6	33	theme	transporters	1112:1123	arg1	specificity					1067:1077	specificity	1067:1077	specificity	1067:1077	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	4	34	theme	dietary	792:798	arg1	biomarker					814:822	a dietary and pathology biomarker	790:822	biomarker	814:822	Here, we describe the molecular mechanism of a phosphotransferase system, highlighted as a dietary and pathology biomarker in the human gut microbiome.
31915220	11	35	theme	strain	2253:2258	arg1	engineering					2260:2270	genetic locus and strain engineering	2235:2270	engineering	2260:2270	In this study, we established a new strategy to profile the specificity of oligosaccharide transporters, combining microbiomics, genetic locus and strain engineering, and state-of-the art metabolomics.
31915220	12	36	theme	transporter	2325:2335	arg1	database					2352:2359	the transporter classification database	2321:2359	the transporter classification database	2321:2359	We revisited the transporter classification database and proposed a new way to classify these membrane proteins based on their structural and mechanistic similarities.
31915220	0	37	theme	Prebiotic	14:22	arg1	Fructooligosaccharides					24:45	Prebiotic Fructooligosaccharides	14:45	Prebiotic Fructooligosaccharides	14:45	Harvesting of Prebiotic Fructooligosaccharides by Nonbeneficial Human Gut Bacteria.
31915220	7	38	theme	Dorea	1371:1375	arg1	transporter					1399:1409	the Dorea fructooligosaccharide transporter	1367:1409	the Dorea fructooligosaccharide transporter	1367:1409	We demonstrated that the Dorea fructooligosaccharide transporter is specific for kestose, whether for binding, transport, or phosphorylation.
31915220	7	38	theme	Dorea	1371:1375	arg1	specific					1414:1421	specific	1414:1421	specific	1414:1421	We demonstrated that the Dorea fructooligosaccharide transporter is specific for kestose, whether for binding, transport, or phosphorylation.
31915220	8	39	theme	known	1632:1636	arg1	diversity					1649:1657	the known functional diversity	1628:1657	the known functional diversity of phosphotransferase systems	1628:1687	This constitutes the biochemical proof of effective phosphorylation of glycosides with a degree of polymerization of more than 2, extending the known functional diversity of phosphotransferase systems.
31915220	3	40	theme	proteins	507:514	arg1	difficulties					454:465	the difficulties	450:465	the difficulties of functionally profiling transmembrane proteins	450:514	Moreover, because of the difficulties of functionally profiling transmembrane proteins, only a few prebiotic transporters have been biochemically characterized to date, while carbohydrate binding and transport are the first and thus crucial steps in their metabolization.
31915220	14	41	theme	diseases	2860:2867	arg1	context					2837:2843	the context	2833:2843	the context of chronic gut diseases	2833:2867	The deciphering of this prebiotic metabolization mechanism by a nonbeneficial bacterium highlights the controversial use of prebiotics, especially in the context of chronic gut diseases.
31915220	11	42	theme	state-of-the	2277:2288	arg1	metabolomics					2294:2305	state-of-the art metabolomics	2277:2305	state-of-the art metabolomics	2277:2305	In this study, we established a new strategy to profile the specificity of oligosaccharide transporters, combining microbiomics, genetic locus and strain engineering, and state-of-the art metabolomics.
31915220	2	43	theme	species	383:389	arg1	ability					325:331	the ability	321:331	the ability of deleterious and uncultured human gut bacterial species to metabolize these functional foods	321:426	However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metabolize these functional foods.
31915220	0	44	theme	Human	64:68	arg1	Bacteria					74:81	Nonbeneficial Human Gut Bacteria	50:81	Nonbeneficial Human Gut Bacteria	50:81	Harvesting of Prebiotic Fructooligosaccharides by Nonbeneficial Human Gut Bacteria.
31915220	14	45	theme	chronic	2848:2854	arg1	diseases					2860:2867	chronic gut diseases	2848:2867	chronic gut diseases	2848:2867	The deciphering of this prebiotic metabolization mechanism by a nonbeneficial bacterium highlights the controversial use of prebiotics, especially in the context of chronic gut diseases.
31915220	8	46	theme	phosphotransferase	1662:1679	arg1	systems					1681:1687	phosphotransferase systems	1662:1687	phosphotransferase systems	1662:1687	This constitutes the biochemical proof of effective phosphorylation of glycosides with a degree of polymerization of more than 2, extending the known functional diversity of phosphotransferase systems.
31915220	2	47	theme	gut	369:371	arg1	species					383:389	deleterious and uncultured human gut bacterial species	336:389	deleterious and uncultured human gut bacterial species	336:389	However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metabolize these functional foods.
31915220	6	48	theme	carbohydrate	1156:1167	arg1	locus					1181:1185	carbohydrate utilization locus and host genome engineering	1156:1213	locus	1181:1185	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	8	49	theme	biochemical	1509:1519	arg1	proof					1521:1525	the biochemical proof	1505:1525	the biochemical proof of effective phosphorylation of glycosides	1505:1568	This constitutes the biochemical proof of effective phosphorylation of glycosides with a degree of polymerization of more than 2, extending the known functional diversity of phosphotransferase systems.
31915220	2	50	theme	functional	411:420	arg1	foods					422:426	these functional foods	405:426	these functional foods	405:426	However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metabolize these functional foods.
31915220	13	51	theme	gut	2668:2670	arg1	pathology					2672:2680	gut pathology	2668:2680	gut pathology	2668:2680	Based on these developments, we identified and characterized, at the molecular level, a fructooligosaccharide transporting phosphotransferase system, which constitutes a biomarker of diet and gut pathology.
31915220	13	52	theme	diet	2659:2662	arg1	biomarker					2646:2654	a biomarker	2644:2654	a biomarker of diet and gut pathology	2644:2680	Based on these developments, we identified and characterized, at the molecular level, a fructooligosaccharide transporting phosphotransferase system, which constitutes a biomarker of diet and gut pathology.
31915220	1	53	theme	gut	220:222	arg1	microbiota					224:233	the gut microbiota	216:233	the gut microbiota	216:233	Prebiotic oligosaccharides, such as fructooligosaccharides, are increasingly being used to modulate the composition and activity of the gut microbiota.
31915220	10	54	theme	prebiotic	2002:2010	arg1	recognition					2012:2022	recognition	2012:2022	recognition	2012:2022	However, little is currently known about the mechanisms of prebiotic recognition and transport by gut bacteria, while these steps are crucial in their metabolism.
31915220	9	55	theme	carbohydrate	1760:1771	arg1	supplements					1838:1848	food supplements	1833:1848	food supplements	1833:1848	Based on these new findings, we revisited the classification of these carbohydrate transporters.IMPORTANCE Prebiotics are increasingly used as food supplements, especially in infant formulas, to modify the functioning and composition of the microbiota.
31915220	9	55	theme	carbohydrate	1760:1771	arg1	Prebiotics					1797:1806	these carbohydrate transporters.IMPORTANCE Prebiotics	1754:1806	these carbohydrate transporters.IMPORTANCE Prebiotics	1754:1806	Based on these new findings, we revisited the classification of these carbohydrate transporters.IMPORTANCE Prebiotics are increasingly used as food supplements, especially in infant formulas, to modify the functioning and composition of the microbiota.
31915220	1	56	used	used	167:170	arg2	fructooligosaccharides					120:141	fructooligosaccharides	120:141	fructooligosaccharides	120:141	Prebiotic oligosaccharides, such as fructooligosaccharides, are increasingly being used to modulate the composition and activity of the gut microbiota.
31915220	1	56	used	used	167:170	arg2	oligosaccharides					94:109	Prebiotic oligosaccharides	84:109	Prebiotic oligosaccharides	84:109	Prebiotic oligosaccharides, such as fructooligosaccharides, are increasingly being used to modulate the composition and activity of the gut microbiota.
31915220	6	57	theme	phosphorylated	1295:1308	arg1	carbohydrates					1310:1322	phosphorylated carbohydrates	1295:1322	phosphorylated carbohydrates	1295:1322	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	2	58	theme	uncultured	352:361	arg1	species					383:389	deleterious and uncultured human gut bacterial species	336:389	deleterious and uncultured human gut bacterial species	336:389	However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metabolize these functional foods.
31915220	14	59	theme	prebiotics	2807:2816	arg1	use					2800:2802	the controversial use	2782:2802	the controversial use of prebiotics	2782:2816	The deciphering of this prebiotic metabolization mechanism by a nonbeneficial bacterium highlights the controversial use of prebiotics, especially in the context of chronic gut diseases.
31915220	11	60	theme	genetic	2235:2241	arg1	locus					2243:2247	genetic locus and strain engineering	2235:2270	locus	2243:2247	In this study, we established a new strategy to profile the specificity of oligosaccharide transporters, combining microbiomics, genetic locus and strain engineering, and state-of-the art metabolomics.
31915220	2	61	theme	deleterious	336:346	arg1	species					383:389	deleterious and uncultured human gut bacterial species	336:389	deleterious and uncultured human gut bacterial species	336:389	However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metabolize these functional foods.
31915220	12	62	theme	mechanistic	2450:2460	arg1	similarities					2462:2473	their structural and mechanistic similarities	2429:2473	their structural and mechanistic similarities	2429:2473	We revisited the transporter classification database and proposed a new way to classify these membrane proteins based on their structural and mechanistic similarities.
31915220	6	63	theme	host	1191:1194	arg1	engineering					1203:1213	carbohydrate utilization locus and host genome engineering	1156:1213	engineering	1203:1213	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	2	64	theme	utilization	258:268	arg1	analyses					270:277	carbohydrate utilization analyses	245:277	carbohydrate utilization analyses	245:277	However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metabolize these functional foods.
31915220	1	65	theme	microbiota	224:233	arg1	activity					204:211	activity	204:211	activity	204:211	Prebiotic oligosaccharides, such as fructooligosaccharides, are increasingly being used to modulate the composition and activity of the gut microbiota.
31915220	1	65	theme	microbiota	224:233	arg1	composition					188:198	composition	188:198	composition	188:198	Prebiotic oligosaccharides, such as fructooligosaccharides, are increasingly being used to modulate the composition and activity of the gut microbiota.
31915220	8	66	theme	phosphorylation	1540:1554	arg1	proof					1521:1525	the biochemical proof	1505:1525	the biochemical proof of effective phosphorylation of glycosides	1505:1568	This constitutes the biochemical proof of effective phosphorylation of glycosides with a degree of polymerization of more than 2, extending the known functional diversity of phosphotransferase systems.
31915220	13	67	theme	fructooligosaccharide	2564:2584	arg1	system					2618:2623	a fructooligosaccharide transporting phosphotransferase system	2562:2623	a fructooligosaccharide transporting phosphotransferase system	2562:2623	Based on these developments, we identified and characterized, at the molecular level, a fructooligosaccharide transporting phosphotransferase system, which constitutes a biomarker of diet and gut pathology.
31915220	12	68	theme	membrane	2402:2409	arg1	proteins					2411:2418	these membrane proteins	2396:2418	these membrane proteins based on their structural and mechanistic similarities	2396:2473	We revisited the transporter classification database and proposed a new way to classify these membrane proteins based on their structural and mechanistic similarities.
31915220	11	69	theme	oligosaccharide	2181:2195	arg1	transporters					2197:2208	oligosaccharide transporters	2181:2208	oligosaccharide transporters	2181:2208	In this study, we established a new strategy to profile the specificity of oligosaccharide transporters, combining microbiomics, genetic locus and strain engineering, and state-of-the art metabolomics.
31915220	8	70	theme	glycosides	1559:1568	arg1	phosphorylation					1540:1554	effective phosphorylation	1530:1554	effective phosphorylation of glycosides	1530:1568	This constitutes the biochemical proof of effective phosphorylation of glycosides with a degree of polymerization of more than 2, extending the known functional diversity of phosphotransferase systems.
31915220	6	71	theme	growth	1265:1270	arg1	rates					1272:1276	growth rates	1265:1276	growth rates	1265:1276	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	4	72	theme	system	767:772	arg1	mechanism					733:741	the molecular mechanism	719:741	the molecular mechanism of a phosphotransferase system, highlighted as a dietary and pathology biomarker in the human gut microbiome	719:850	Here, we describe the molecular mechanism of a phosphotransferase system, highlighted as a dietary and pathology biomarker in the human gut microbiome.
31915220	13	73	theme	phosphotransferase	2599:2616	arg1	system					2618:2623	a fructooligosaccharide transporting phosphotransferase system	2562:2623	a fructooligosaccharide transporting phosphotransferase system	2562:2623	Based on these developments, we identified and characterized, at the molecular level, a fructooligosaccharide transporting phosphotransferase system, which constitutes a biomarker of diet and gut pathology.
31915220	5	74	theme	Dorea	972:976	arg1	species					978:984	Dorea species	972:984	Dorea species	972:984	This transporter is encoded by a metagenomic locus that is highly conserved in several human gut Firmicutes, including Dorea species.
31915220	12	75	theme	structural	2435:2444	arg1	similarities					2462:2473	their structural and mechanistic similarities	2429:2473	their structural and mechanistic similarities	2429:2473	We revisited the transporter classification database and proposed a new way to classify these membrane proteins based on their structural and mechanistic similarities.
31915220	3	76	theme	crucial	662:668	arg1	steps					670:674	thus crucial steps	657:674	thus crucial steps in their metabolization	657:698	Moreover, because of the difficulties of functionally profiling transmembrane proteins, only a few prebiotic transporters have been biochemically characterized to date, while carbohydrate binding and transport are the first and thus crucial steps in their metabolization.
31915220	5	77	theme	several	932:938	arg1	Firmicutes					950:959	several human gut Firmicutes	932:959	several human gut Firmicutes	932:959	This transporter is encoded by a metagenomic locus that is highly conserved in several human gut Firmicutes, including Dorea species.
31915220	5	77	theme	several	932:938	arg1	species					978:984	Dorea species	972:984	Dorea species	972:984	This transporter is encoded by a metagenomic locus that is highly conserved in several human gut Firmicutes, including Dorea species.
31915220	9	78	theme	infant	1865:1870	arg1	formulas					1872:1879	infant formulas	1865:1879	infant formulas	1865:1879	Based on these new findings, we revisited the classification of these carbohydrate transporters.IMPORTANCE Prebiotics are increasingly used as food supplements, especially in infant formulas, to modify the functioning and composition of the microbiota.
31915220	5	79	theme	gut	946:948	arg1	Firmicutes					950:959	several human gut Firmicutes	932:959	several human gut Firmicutes	932:959	This transporter is encoded by a metagenomic locus that is highly conserved in several human gut Firmicutes, including Dorea species.
31915220	5	79	theme	gut	946:948	arg1	species					978:984	Dorea species	972:984	Dorea species	972:984	This transporter is encoded by a metagenomic locus that is highly conserved in several human gut Firmicutes, including Dorea species.
31915220	14	80	theme	prebiotic	2707:2715	arg1	mechanism					2732:2740	this prebiotic metabolization mechanism	2702:2740	this prebiotic metabolization mechanism	2702:2740	The deciphering of this prebiotic metabolization mechanism by a nonbeneficial bacterium highlights the controversial use of prebiotics, especially in the context of chronic gut diseases.
31915220	13	81	theme	molecular	2545:2553	arg1	level					2555:2559	the molecular level	2541:2559	the molecular level	2541:2559	Based on these developments, we identified and characterized, at the molecular level, a fructooligosaccharide transporting phosphotransferase system, which constitutes a biomarker of diet and gut pathology.
31915220	12	82	theme	new	2376:2378	arg1	way					2380:2382	a new way	2374:2382	a new way to classify these membrane proteins based on their structural and mechanistic similarities	2374:2473	We revisited the transporter classification database and proposed a new way to classify these membrane proteins based on their structural and mechanistic similarities.
31915220	12	83	theme	classification	2337:2350	arg1	database					2352:2359	the transporter classification database	2321:2359	the transporter classification database	2321:2359	We revisited the transporter classification database and proposed a new way to classify these membrane proteins based on their structural and mechanistic similarities.
31915220	2	84	theme	human	363:367	arg1	species					383:389	deleterious and uncultured human gut bacterial species	336:389	deleterious and uncultured human gut bacterial species	336:389	However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metabolize these functional foods.
31915220	4	85	from	biomarker	814:822	arg1	microbiome					841:850	the human gut microbiome	827:850	the human gut microbiome	827:850	Here, we describe the molecular mechanism of a phosphotransferase system, highlighted as a dietary and pathology biomarker in the human gut microbiome.
31915220	1	86	theme	Prebiotic	84:92	arg1	oligosaccharides					94:109	Prebiotic oligosaccharides	84:109	Prebiotic oligosaccharides	84:109	Prebiotic oligosaccharides, such as fructooligosaccharides, are increasingly being used to modulate the composition and activity of the gut microbiota.
31915220	1	86	theme	Prebiotic	84:92	arg1	fructooligosaccharides					120:141	fructooligosaccharides	120:141	fructooligosaccharides	120:141	Prebiotic oligosaccharides, such as fructooligosaccharides, are increasingly being used to modulate the composition and activity of the gut microbiota.
31915220	3	87	theme	transmembrane	493:505	arg1	proteins					507:514	functionally profiling transmembrane proteins	470:514	functionally profiling transmembrane proteins	470:514	Moreover, because of the difficulties of functionally profiling transmembrane proteins, only a few prebiotic transporters have been biochemically characterized to date, while carbohydrate binding and transport are the first and thus crucial steps in their metabolization.
31915220	14	88	theme	controversial	2786:2798	arg1	use					2800:2802	the controversial use	2782:2802	the controversial use of prebiotics	2782:2816	The deciphering of this prebiotic metabolization mechanism by a nonbeneficial bacterium highlights the controversial use of prebiotics, especially in the context of chronic gut diseases.
31915220	10	89	from	metabolism	2094:2103	arg1	crucial					2077:2083	crucial	2077:2083	crucial	2077:2083	However, little is currently known about the mechanisms of prebiotic recognition and transport by gut bacteria, while these steps are crucial in their metabolism.
31915220	6	90	theme	recombinant	1100:1110	arg1	transporters					1112:1123	recombinant transporters	1100:1123	recombinant transporters	1100:1123	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	0	91	theme	Fructooligosaccharides	24:45	arg1	Harvesting					0:9	Harvesting	0:9	Harvesting of Prebiotic Fructooligosaccharides by Nonbeneficial Human Gut Bacteria.	0:82	Harvesting of Prebiotic Fructooligosaccharides by Nonbeneficial Human Gut Bacteria.
31915220	8	92	theme	functional	1638:1647	arg1	diversity					1649:1657	the known functional diversity	1628:1657	the known functional diversity of phosphotransferase systems	1628:1687	This constitutes the biochemical proof of effective phosphorylation of glycosides with a degree of polymerization of more than 2, extending the known functional diversity of phosphotransferase systems.
31915220	0	93	theme	Nonbeneficial	50:62	arg1	Bacteria					74:81	Nonbeneficial Human Gut Bacteria	50:81	Nonbeneficial Human Gut Bacteria	50:81	Harvesting of Prebiotic Fructooligosaccharides by Nonbeneficial Human Gut Bacteria.
31915220	0	94	theme	Gut	70:72	arg1	Bacteria					74:81	Nonbeneficial Human Gut Bacteria	50:81	Nonbeneficial Human Gut Bacteria	50:81	Harvesting of Prebiotic Fructooligosaccharides by Nonbeneficial Human Gut Bacteria.
31915220	14	95	theme	gut	2856:2858	arg1	diseases					2860:2867	chronic gut diseases	2848:2867	chronic gut diseases	2848:2867	The deciphering of this prebiotic metabolization mechanism by a nonbeneficial bacterium highlights the controversial use of prebiotics, especially in the context of chronic gut diseases.
31915220	11	96	theme	art	2290:2292	arg1	metabolomics					2294:2305	state-of-the art metabolomics	2277:2305	state-of-the art metabolomics	2277:2305	In this study, we established a new strategy to profile the specificity of oligosaccharide transporters, combining microbiomics, genetic locus and strain engineering, and state-of-the art metabolomics.
31915220	8	97	theme	systems	1681:1687	arg1	diversity					1649:1657	the known functional diversity	1628:1657	the known functional diversity of phosphotransferase systems	1628:1687	This constitutes the biochemical proof of effective phosphorylation of glycosides with a degree of polymerization of more than 2, extending the known functional diversity of phosphotransferase systems.
31915220	2	98	theme	bacterial	373:381	arg1	species					383:389	deleterious and uncultured human gut bacterial species	336:389	deleterious and uncultured human gut bacterial species	336:389	However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metabolize these functional foods.
31915220	9	99	used	used	1825:1828	arg2	Prebiotics					1797:1806	these carbohydrate transporters.IMPORTANCE Prebiotics	1754:1806	these carbohydrate transporters.IMPORTANCE Prebiotics	1754:1806	Based on these new findings, we revisited the classification of these carbohydrate transporters.IMPORTANCE Prebiotics are increasingly used as food supplements, especially in infant formulas, to modify the functioning and composition of the microbiota.
31915220	9	99	used	used	1825:1828	arg2	supplements					1838:1848	food supplements	1833:1848	food supplements	1833:1848	Based on these new findings, we revisited the classification of these carbohydrate transporters.IMPORTANCE Prebiotics are increasingly used as food supplements, especially in infant formulas, to modify the functioning and composition of the microbiota.
31915220	9	100	theme	new	1705:1707	arg1	findings					1709:1716	these new findings	1699:1716	these new findings	1699:1716	Based on these new findings, we revisited the classification of these carbohydrate transporters.IMPORTANCE Prebiotics are increasingly used as food supplements, especially in infant formulas, to modify the functioning and composition of the microbiota.
31915220	6	101	theme	utilization	1169:1179	arg1	locus					1181:1185	carbohydrate utilization locus and host genome engineering	1156:1213	locus	1181:1185	We developed a generic strategy to deeply analyze, in vitro and in cellulo, the specificity and functionality of recombinant transporters in Escherichia coli, combining carbohydrate utilization locus and host genome engineering and quantification of the binding, transport, and growth rates with analysis of phosphorylated carbohydrates by mass spectrometry.
31915220	4	102	theme	gut	837:839	arg1	microbiome					841:850	the human gut microbiome	827:850	the human gut microbiome	827:850	Here, we describe the molecular mechanism of a phosphotransferase system, highlighted as a dietary and pathology biomarker in the human gut microbiome.
31915220	3	103	theme	prebiotic	528:536	arg1	transporters					538:549	only a few prebiotic transporters	517:549	only a few prebiotic transporters	517:549	Moreover, because of the difficulties of functionally profiling transmembrane proteins, only a few prebiotic transporters have been biochemically characterized to date, while carbohydrate binding and transport are the first and thus crucial steps in their metabolization.
31915220	10	104	theme	transport	2028:2036	arg1	mechanisms					1988:1997	the mechanisms	1984:1997	the mechanisms of prebiotic recognition and transport by gut bacteria	1984:2052	However, little is currently known about the mechanisms of prebiotic recognition and transport by gut bacteria, while these steps are crucial in their metabolism.
32059915	3	0	with	material	605:612	arg1	performance					629:639	excellent performance	619:639	excellent performance	619:639	In addition, in order to obtain a material with excellent performance, particles of uniform size of about 100 nm are obtained by fractional centrifugation.
32059915	2	1	theme	wide	351:354	arg1	range					356:360	a wide range	349:360	a wide range of 200-2500 nm	349:375	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	5	2	theme	food	1098:1101	arg1	preservation					1103:1114	food preservation	1098:1114	food preservation	1098:1114	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	1	3	theme	ultraviolet	242:252	arg1	light					259:263	ultraviolet (UV) light	242:263	ultraviolet (UV) light	242:263	Light is a major factor in promoting food aging and deterioration, especially for ultraviolet (UV) light.
32059915	0	4	theme	original	79:86	arg1	melanin					88:94	natural original melanin	71:94	natural original melanin	71:94	High performance of alginate/polyvinyl alcohol composite film based on natural original melanin nanoparticles used as food thermal insulating and UV-vis block.
32059915	2	5	theme	thermal	523:529	arg1	properties					542:551	excellent thermal insulating properties	513:551	excellent thermal insulating properties	513:551	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	2	6	from	materials	451:459	arg1	work					469:472	this work	464:472	this work	464:472	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	5	7	dep	non-polluting	909:921	arg1	biocompatible					939:951	biocompatible	939:951	biocompatible	939:951	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	5	7	dep	non-polluting	909:921	arg1	biodegradable					924:936	biodegradable	924:936	biodegradable	924:936	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	1	8	theme	UV	255:256	arg1	light					259:263	ultraviolet (UV) light	242:263	ultraviolet (UV) light	242:263	Light is a major factor in promoting food aging and deterioration, especially for ultraviolet (UV) light.
32059915	2	9	theme	excellent	513:521	arg1	properties					542:551	excellent thermal insulating properties	513:551	excellent thermal insulating properties	513:551	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	3	10	theme	fractional	700:709	arg1	centrifugation					711:724	fractional centrifugation	700:724	fractional centrifugation	700:724	In addition, in order to obtain a material with excellent performance, particles of uniform size of about 100 nm are obtained by fractional centrifugation.
32059915	5	11	theme	excellent	963:971	arg1	properties					984:993	excellent mechanical properties	963:993	excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation	963:1114	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	0	12	theme	food	118:121	arg1	insulating					131:140	food thermal insulating	118:140	food thermal insulating	118:140	High performance of alginate/polyvinyl alcohol composite film based on natural original melanin nanoparticles used as food thermal insulating and UV-vis block.
32059915	4	13	theme	UV-vis	756:761	arg1	block					763:767	UV-vis block	756:767	UV-vis block	756:767	It was found the mechanical, UV-vis block and thermal insulating properties were improved significantly compared with the control samples.
32059915	5	14	contain	has	1035:1037	arg2	applications					1049:1060	potential applications	1039:1060	potential applications in thermal insulating materials for food preservation	1039:1114	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	5	14	contain	has	1035:1037	arg1	properties					984:993	excellent mechanical properties	963:993	excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation	963:1114	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	2	15	theme	UV-vis	478:483	arg1	block					485:489	UV-vis block	478:489	UV-vis block	478:489	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	0	16	dep	nanoparticles	96:108	arg1	used					110:113	used	110:113	nanoparticles used as food thermal insulating and UV-vis block	96:157	High performance of alginate/polyvinyl alcohol composite film based on natural original melanin nanoparticles used as food thermal insulating and UV-vis block.
32059915	1	17	theme	major	171:175	arg1	factor					177:182	a major factor	169:182	a major factor in promoting food aging and deterioration, especially for ultraviolet (UV) light	169:263	Light is a major factor in promoting food aging and deterioration, especially for ultraviolet (UV) light.
32059915	1	17	theme	major	171:175	arg1	Light					160:164	Light	160:164	Light	160:164	Light is a major factor in promoting food aging and deterioration, especially for ultraviolet (UV) light.
32059915	4	18	theme	control	849:855	arg1	samples					857:863	the control samples	845:863	the control samples	845:863	It was found the mechanical, UV-vis block and thermal insulating properties were improved significantly compared with the control samples.
32059915	5	19	from	applications	1049:1060	arg1	materials					1084:1092	thermal insulating materials	1065:1092	thermal insulating materials	1065:1092	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	0	20	theme	High	0:3	arg1	performance					5:15	High performance	0:15	High performance of alginate/polyvinyl alcohol composite film based on natural original melanin	0:94	High performance of alginate/polyvinyl alcohol composite film based on natural original melanin nanoparticles used as food thermal insulating and UV-vis block.
32059915	2	21	theme	solid	303:307	arg1	nanoparticles					309:321	bioinspired dopamine-melanin solid nanoparticles	274:321	bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm	274:375	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	2	22	theme	200-2500 nm	365:375	arg1	range					356:360	a wide range	349:360	a wide range of 200-2500 nm	349:375	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	0	23	theme	alginate/polyvinyl	20:37	arg1	film					57:60	alginate/polyvinyl alcohol composite film	20:60	alginate/polyvinyl alcohol composite film	20:60	High performance of alginate/polyvinyl alcohol composite film based on natural original melanin nanoparticles used as food thermal insulating and UV-vis block.
32059915	2	24	from	range	356:360	arg1	absorption					335:344	strong absorption	328:344	strong absorption at a wide range of 200-2500 nm	328:375	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	2	25	theme	dopamine-melanin	286:301	arg1	nanoparticles					309:321	bioinspired dopamine-melanin solid nanoparticles	274:321	bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm	274:375	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	0	26	theme	thermal	123:129	arg1	insulating					131:140	food thermal insulating	118:140	food thermal insulating	118:140	High performance of alginate/polyvinyl alcohol composite film based on natural original melanin nanoparticles used as food thermal insulating and UV-vis block.
32059915	5	27	theme	thermal	1065:1071	arg1	materials					1084:1092	thermal insulating materials	1065:1092	thermal insulating materials	1065:1092	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	2	28	theme	bioinspired	274:284	arg1	nanoparticles					309:321	bioinspired dopamine-melanin solid nanoparticles	274:321	bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm	274:375	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	1	29	theme	food	197:200	arg1	aging					202:206	food aging	197:206	food aging	197:206	Light is a major factor in promoting food aging and deterioration, especially for ultraviolet (UV) light.
32059915	0	30	theme	composite	47:55	arg1	film					57:60	alginate/polyvinyl alcohol composite film	20:60	alginate/polyvinyl alcohol composite film	20:60	High performance of alginate/polyvinyl alcohol composite film based on natural original melanin nanoparticles used as food thermal insulating and UV-vis block.
32059915	0	31	theme	UV-vis	146:151	arg1	block					153:157	UV-vis block	146:157	UV-vis block	146:157	High performance of alginate/polyvinyl alcohol composite film based on natural original melanin nanoparticles used as food thermal insulating and UV-vis block.
32059915	5	32	theme	insulating	1073:1082	arg1	materials					1084:1092	thermal insulating materials	1065:1092	thermal insulating materials	1065:1092	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	5	33	with	film	953:956	arg1	properties					984:993	excellent mechanical properties	963:993	excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation	963:1114	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	2	34	theme	alginate/polyvinyl	406:423	arg1	alcohol					425:431	alginate/polyvinyl alcohol	406:431	alginate/polyvinyl alcohol	406:431	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	0	35	theme	alcohol	39:45	arg1	film					57:60	alginate/polyvinyl alcohol composite film	20:60	alginate/polyvinyl alcohol composite film	20:60	High performance of alginate/polyvinyl alcohol composite film based on natural original melanin nanoparticles used as food thermal insulating and UV-vis block.
32059915	2	36	theme	insulating	531:540	arg1	properties					542:551	excellent thermal insulating properties	513:551	excellent thermal insulating properties	513:551	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	3	37	theme	excellent	619:627	arg1	performance					629:639	excellent performance	619:639	excellent performance	619:639	In addition, in order to obtain a material with excellent performance, particles of uniform size of about 100 nm are obtained by fractional centrifugation.
32059915	2	38	theme	film	446:449	arg1	materials					451:459	film materials	446:459	film materials in this work for UV-vis block	446:489	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	5	39	used	used	1007:1010	arg2	properties					984:993	excellent mechanical properties	963:993	excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation	963:1114	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	0	40	theme	film	57:60	arg1	performance					5:15	High performance	0:15	High performance of alginate/polyvinyl alcohol composite film based on natural original melanin	0:94	High performance of alginate/polyvinyl alcohol composite film based on natural original melanin nanoparticles used as food thermal insulating and UV-vis block.
32059915	3	41	theme	size	663:666	arg1	particles					642:650	particles	642:650	particles of uniform size of about 100 nm	642:682	In addition, in order to obtain a material with excellent performance, particles of uniform size of about 100 nm are obtained by fractional centrifugation.
32059915	5	42	theme	potential	1039:1047	arg1	applications					1049:1060	potential applications	1039:1060	potential applications in thermal insulating materials for food preservation	1039:1114	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	5	43	theme	UV-vis	1015:1020	arg1	barriers					1022:1029	UV-vis barriers	1015:1029	UV-vis barriers	1015:1029	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	2	44	theme	strong	328:333	arg1	absorption					335:344	strong absorption	328:344	strong absorption at a wide range of 200-2500 nm	328:375	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	5	45	theme	mechanical	973:982	arg1	properties					984:993	excellent mechanical properties	963:993	excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation	963:1114	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	5	46	theme	non-polluting	909:921	arg1	film					953:956	a non-polluting, biodegradable, biocompatible film	907:956	a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation	907:1114	This study provides a strategy to design a non-polluting, biodegradable, biocompatible film with excellent mechanical properties that can be used in UV-vis barriers and has potential applications in thermal insulating materials for food preservation.
32059915	0	47	theme	natural	71:77	arg1	melanin					88:94	natural original melanin	71:94	natural original melanin	71:94	High performance of alginate/polyvinyl alcohol composite film based on natural original melanin nanoparticles used as food thermal insulating and UV-vis block.
32059915	3	48	theme	uniform	655:661	arg1	size					663:666	uniform size	655:666	uniform size of about 100 nm	655:682	In addition, in order to obtain a material with excellent performance, particles of uniform size of about 100 nm are obtained by fractional centrifugation.
32059915	4	49	theme	insulating	781:790	arg1	properties					792:801	thermal insulating properties	773:801	thermal insulating properties	773:801	It was found the mechanical, UV-vis block and thermal insulating properties were improved significantly compared with the control samples.
32059915	2	50	with	nanoparticles	309:321	arg1	absorption					335:344	strong absorption	328:344	strong absorption at a wide range of 200-2500 nm	328:375	Herein, bioinspired dopamine-melanin solid nanoparticles with strong absorption at a wide range of 200-2500 nm were first incorporated into alginate/polyvinyl alcohol to fabricate film materials in this work for UV-vis block, and this also brings excellent thermal insulating properties to the materials.
32059915	3	51	theme	nm	681:682	arg1	size					663:666	uniform size	655:666	uniform size of about 100 nm	655:682	In addition, in order to obtain a material with excellent performance, particles of uniform size of about 100 nm are obtained by fractional centrifugation.
32059915	4	52	theme	thermal	773:779	arg1	properties					792:801	thermal insulating properties	773:801	thermal insulating properties	773:801	It was found the mechanical, UV-vis block and thermal insulating properties were improved significantly compared with the control samples.
34491402	8	0	theme	Chitosan-chelated	1801:1817	arg1	zinc					1819:1822	• Chitosan-chelated zinc	1799:1822	• Chitosan-chelated zinc	1799:1822	KEY POINTS: • Chitosan-chelated zinc significantly modulated ileal microbiota.
34491402	4	1	theme	propionate	877:886	arg1	concentrations					859:872	The concentrations	855:872	The concentrations of propionate, butyrate, and lactate in the CS-Zn group piglets	855:936	The concentrations of propionate, butyrate, and lactate in the CS-Zn group piglets were significantly increased, while the pH value was significantly decreased.
34491402	10	2	theme	host	1967:1970	arg1	health					1972:1977	host health	1967:1977	host health	1967:1977	• The ileal microbiota plays an important role in host health.
34491402	5	3	theme	group	1335:1339	arg1	NF-κB					1316:1320	NF-κB	1316:1320	NF-κB	1316:1320	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	5	3	theme	group	1335:1339	arg1	TLR4					1299:1302	TLR4	1299:1302	TLR4	1299:1302	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	5	3	theme	group	1335:1339	arg1	MyD88					1305:1309	MyD88	1305:1309	MyD88	1305:1309	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	6	4	theme	protein	1420:1426	arg1	expression					1428:1437	the protein expression	1416:1437	the protein expression of occludin and claudin-1	1416:1463	In addition, the mRNA expression of IGF-1 was increased, the protein expression of occludin and claudin-1 was enhanced, while the mRNA expression of caspase 3 and caspase 8 was decreased in the CS-Zn group.
34491402	5	5	theme	Zn/kg	1166:1170	arg1	diet					1178:1181	1600 mg Zn/kg basal diet	1158:1181	1600 mg Zn/kg basal diet	1158:1181	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	2	6	theme	crypt	623:627	arg1	depth					629:633	crypt depth	623:633	crypt depth	623:633	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	7	7	theme	microbiota	1649:1658	arg1	composition					1628:1638	the composition	1624:1638	the composition of ileal microbiota	1624:1658	These results suggest CS-Zn treatment could help modulate the composition of ileal microbiota, attenuate inflammatory response, and maintain the intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	5	8	from	ZnO	1189:1191	arg1	diet					1178:1181	1600 mg Zn/kg basal diet	1158:1181	1600 mg Zn/kg basal diet	1158:1181	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	5	8	from	ZnO	1189:1191	arg1	dose					1150:1153	pharmacological dose	1134:1153	pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO	1134:1191	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	3	9	contain	had	656:658	arg2	abundance					669:677	a higher abundance	660:677	a higher abundance of Lactobacillus in the ileal digesta	660:715	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	3	9	contain	had	656:658	arg1	piglets					648:654	CS-Zn group piglets	636:654	CS-Zn group piglets	636:654	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	5	10	from	TNF-α	1058:1062	arg1	mucosa					1093:1098	the ileal mucosa	1083:1098	the ileal mucosa of the CS-Zn	1083:1111	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	1	11	theme	barrier	276:282	arg1	function					284:291	barrier function	276:291	barrier function	276:291	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	1	12	from	function	284:291	arg1	piglets					303:309	weaned piglets	296:309	weaned piglets challenged with Escherichia coli K88	296:346	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	5	13	theme	NF-κB	1316:1320	arg1	expression					1285:1294	the mRNA expression	1276:1294	the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group	1276:1339	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	6	14	theme	CS-Zn	1553:1557	arg1	group					1559:1563	the CS-Zn group	1549:1563	the CS-Zn group	1549:1563	In addition, the mRNA expression of IGF-1 was increased, the protein expression of occludin and claudin-1 was enhanced, while the mRNA expression of caspase 3 and caspase 8 was decreased in the CS-Zn group.
34491402	3	15	theme	Escherichia	756:766	arg1	shigella					768:775	Escherichia shigella	756:775	Escherichia shigella	756:775	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	1	16	from	response	262:269	arg1	piglets					303:309	weaned piglets	296:309	weaned piglets challenged with Escherichia coli K88	296:346	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	10	17	theme	ileal	1923:1927	arg1	microbiota					1929:1938	• The ileal microbiota	1917:1938	• The ileal microbiota	1917:1938	• The ileal microbiota plays an important role in host health.
34491402	1	18	theme	zinc	223:226	arg1	effects					194:200	the effects	190:200	the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88	190:346	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	4	19	theme	butyrate	889:896	arg1	concentrations					859:872	The concentrations	855:872	The concentrations of propionate, butyrate, and lactate in the CS-Zn group piglets	855:936	The concentrations of propionate, butyrate, and lactate in the CS-Zn group piglets were significantly increased, while the pH value was significantly decreased.
34491402	3	20	theme	Streptococcus	741:753	arg1	abundance					728:736	the abundance	724:736	the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6	724:824	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	8	21	theme	•	1799:1799	arg1	zinc					1819:1822	• Chitosan-chelated zinc	1799:1822	• Chitosan-chelated zinc	1799:1822	KEY POINTS: • Chitosan-chelated zinc significantly modulated ileal microbiota.
34491402	1	22	from	effects	194:200	arg1	microbiota					237:246	ileal microbiota	231:246	ileal microbiota	231:246	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	1	22	from	effects	194:200	arg1	response					262:269	inflammatory response	249:269	inflammatory response	249:269	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	1	22	from	effects	194:200	arg1	function					284:291	barrier function	276:291	barrier function	276:291	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	2	23	theme	ileal	570:574	arg1	height					583:588	significantly increased ileal villus height	546:588	significantly increased ileal villus height	546:588	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	7	24	theme	CS-Zn	1588:1592	arg1	treatment					1594:1602	CS-Zn treatment	1588:1602	CS-Zn treatment	1588:1602	These results suggest CS-Zn treatment could help modulate the composition of ileal microbiota, attenuate inflammatory response, and maintain the intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	6	25	theme	caspase	1522:1528	arg1	expression					1494:1503	the mRNA expression	1485:1503	the mRNA expression of caspase 3 and caspase 8	1485:1530	In addition, the mRNA expression of IGF-1 was increased, the protein expression of occludin and claudin-1 was enhanced, while the mRNA expression of caspase 3 and caspase 8 was decreased in the CS-Zn group.
34491402	9	26	theme	Chitosan-chelated	1868:1884	arg1	zinc					1886:1889	• Chitosan-chelated zinc	1866:1889	• Chitosan-chelated zinc	1866:1889	• Chitosan-chelated zinc can improve ileal health.
34491402	5	27	from	IL-1β	1051:1055	arg1	mucosa					1093:1098	the ileal mucosa	1083:1098	the ileal mucosa of the CS-Zn	1083:1111	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	0	28	dep	Escherichia	138:148	arg1	coli					150:153	coli	150:153	coli	150:153	Chitosan-chelated zinc modulates ileal microbiota, ileal microbial metabolites, and intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	2	29	theme	treatment	496:504	arg1	Piglets					349:355	Piglets	349:355	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet)	349:540	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	5	30	from	group	1127:1131	arg1	mucosa					1093:1098	the ileal mucosa	1083:1098	the ileal mucosa of the CS-Zn	1083:1111	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	3	31	theme	stricto	816:822	arg1	abundance					728:736	the abundance	724:736	the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6	724:824	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	5	32	from	concentrations	1033:1046	arg1	mucosa					1093:1098	the ileal mucosa	1083:1098	the ileal mucosa of the CS-Zn	1083:1111	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	4	33	from	concentrations	859:872	arg1	piglets					930:936	the CS-Zn group piglets	914:936	the CS-Zn group piglets	914:936	The concentrations of propionate, butyrate, and lactate in the CS-Zn group piglets were significantly increased, while the pH value was significantly decreased.
34491402	2	34	theme	basal	530:534	arg1	diet					536:539	766 mg chitosan/kg basal diet	511:539	766 mg chitosan/kg basal diet	511:539	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	2	34	theme	basal	530:534	arg1	CS					507:508	CS	507:508	CS	507:508	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	5	35	dep	group	1127:1131	arg1	dose					1150:1153	pharmacological dose	1134:1153	pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO	1134:1191	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	9	36	theme	ileal	1903:1907	arg1	health					1909:1914	ileal health	1903:1914	ileal health	1903:1914	• Chitosan-chelated zinc can improve ileal health.
34491402	3	37	theme	Clostridium	798:808	arg1	stricto					816:822	Clostridium sensu stricto 6	798:824	Clostridium sensu stricto 6	798:824	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	5	38	from	MPO	1065:1067	arg1	mucosa					1093:1098	the ileal mucosa	1083:1098	the ileal mucosa of the CS-Zn	1083:1111	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	6	39	theme	caspase	1508:1514	arg1	expression					1494:1503	the mRNA expression	1485:1503	the mRNA expression of caspase 3 and caspase 8	1485:1530	In addition, the mRNA expression of IGF-1 was increased, the protein expression of occludin and claudin-1 was enhanced, while the mRNA expression of caspase 3 and caspase 8 was decreased in the CS-Zn group.
34491402	8	40	dep	POINTS	1791:1796	arg1	modulated					1838:1846	modulated	1838:1846	modulated ileal microbiota	1838:1863	KEY POINTS: • Chitosan-chelated zinc significantly modulated ileal microbiota.
34491402	2	41	theme	766 mg	511:516	arg1	diet					536:539	766 mg chitosan/kg basal diet	511:539	766 mg chitosan/kg basal diet	511:539	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	2	41	theme	766 mg	511:516	arg1	CS					507:508	CS	507:508	CS	507:508	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	1	42	dep	Escherichia	327:337	arg1	coli					339:342	coli	339:342	coli	339:342	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	5	43	theme	basal	1260:1264	arg1	diet					1266:1269	basal diet	1260:1269	basal diet	1260:1269	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	0	44	theme	weaned	107:112	arg1	piglets					114:120	weaned piglets	107:120	weaned piglets challenged with Escherichia coli K88	107:157	Chitosan-chelated zinc modulates ileal microbiota, ileal microbial metabolites, and intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	5	45	theme	INF-γ	1074:1078	arg1	concentrations					1033:1046	the concentrations	1029:1046	the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO)	1029:1192	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	5	45	theme	INF-γ	1074:1078	arg1	lower					1213:1217	lower	1213:1217	lower	1213:1217	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	2	46	theme	chitosan-chelated	455:471	arg1	zinc					473:476	chitosan-chelated zinc	455:476	chitosan-chelated zinc	455:476	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	5	47	theme	pharmacological	1134:1148	arg1	dose					1150:1153	pharmacological dose	1134:1153	pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO	1134:1191	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	0	48	theme	Chitosan-chelated	0:16	arg1	zinc					18:21	Chitosan-chelated zinc	0:21	Chitosan-chelated zinc	0:21	Chitosan-chelated zinc modulates ileal microbiota, ileal microbial metabolites, and intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	5	49	theme	H-ZnO	1121:1125	arg1	group					1127:1131	the H-ZnO group	1117:1131	the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO)	1117:1192	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	7	50	dep	suggest	1580:1586	arg1	help					1610:1613	help	1610:1613	suggest CS-Zn treatment could help modulate the composition of ileal microbiota, attenuate inflammatory response, and maintain the intestinal function in weaned piglets challenged with Escherichia coli K88	1580:1784	These results suggest CS-Zn treatment could help modulate the composition of ileal microbiota, attenuate inflammatory response, and maintain the intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	5	51	theme	control	1237:1243	arg1	group					1245:1249	the control group	1233:1249	the control group fed with basal diet	1233:1269	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	2	52	theme	basal	438:442	arg1	diet					444:447	100 mg zinc + 766 mg chitosan/kg basal diet	405:447	100 mg zinc + 766 mg chitosan/kg basal diet	405:447	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	3	53	theme	group	642:646	arg1	piglets					648:654	CS-Zn group piglets	636:654	CS-Zn group piglets	636:654	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	2	54	theme	zinc + 766 mg	412:424	arg1	diet					444:447	100 mg zinc + 766 mg chitosan/kg basal diet	405:447	100 mg zinc + 766 mg chitosan/kg basal diet	405:447	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	7	55	theme	Escherichia	1765:1775	arg1	K88					1782:1784	Escherichia coli K88	1765:1784	Escherichia coli K88	1765:1784	These results suggest CS-Zn treatment could help modulate the composition of ileal microbiota, attenuate inflammatory response, and maintain the intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	7	56	theme	intestinal	1711:1720	arg1	function					1722:1729	the intestinal function	1707:1729	the intestinal function in weaned piglets challenged with Escherichia coli K88	1707:1784	These results suggest CS-Zn treatment could help modulate the composition of ileal microbiota, attenuate inflammatory response, and maintain the intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	7	57	from	function	1722:1729	arg1	piglets					1741:1747	weaned piglets	1734:1747	weaned piglets challenged with Escherichia coli K88	1734:1784	These results suggest CS-Zn treatment could help modulate the composition of ileal microbiota, attenuate inflammatory response, and maintain the intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	5	58	theme	TLR4	1299:1302	arg1	expression					1285:1294	the mRNA expression	1276:1294	the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group	1276:1339	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	0	59	theme	ileal	51:55	arg1	metabolites					67:77	ileal microbial metabolites	51:77	ileal microbial metabolites	51:77	Chitosan-chelated zinc modulates ileal microbiota, ileal microbial metabolites, and intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	3	60	theme	higher	662:667	arg1	abundance					669:677	a higher abundance	660:677	a higher abundance of Lactobacillus in the ileal digesta	660:715	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	5	61	theme	MyD88	1305:1309	arg1	expression					1285:1294	the mRNA expression	1276:1294	the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group	1276:1339	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	5	62	theme	basal	1172:1176	arg1	diet					1178:1181	1600 mg Zn/kg basal diet	1158:1181	1600 mg Zn/kg basal diet	1158:1181	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	7	63	theme	weaned	1734:1739	arg1	piglets					1741:1747	weaned piglets	1734:1747	weaned piglets challenged with Escherichia coli K88	1734:1784	These results suggest CS-Zn treatment could help modulate the composition of ileal microbiota, attenuate inflammatory response, and maintain the intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	10	64	theme	important	1949:1957	arg1	role					1959:1962	an important role	1946:1962	an important role	1946:1962	• The ileal microbiota plays an important role in host health.
34491402	2	65	theme	zinc	382:385	arg1	treatment					387:395	the chitosan-chelated zinc treatment	360:395	the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc)	360:477	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	3	66	theme	Actinobacillus	778:791	arg1	abundance					728:736	the abundance	724:736	the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6	724:824	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	7	67	theme	inflammatory	1671:1682	arg1	response					1684:1691	inflammatory response	1671:1691	inflammatory response	1671:1691	These results suggest CS-Zn treatment could help modulate the composition of ileal microbiota, attenuate inflammatory response, and maintain the intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	1	68	theme	inflammatory	249:260	arg1	response					262:269	inflammatory response	249:269	inflammatory response	249:269	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	5	69	theme	CS-Zn	1329:1333	arg1	group					1335:1339	the CS-Zn group	1325:1339	the CS-Zn group	1325:1339	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	5	70	theme	1600 mg	1158:1164	arg1	diet					1178:1181	1600 mg Zn/kg basal diet	1158:1181	1600 mg Zn/kg basal diet	1158:1181	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	7	71	theme	ileal	1643:1647	arg1	microbiota					1649:1658	ileal microbiota	1643:1658	ileal microbiota	1643:1658	These results suggest CS-Zn treatment could help modulate the composition of ileal microbiota, attenuate inflammatory response, and maintain the intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	3	72	theme	ileal	703:707	arg1	digesta					709:715	the ileal digesta	699:715	the ileal digesta	699:715	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	2	73	theme	villi	607:611	arg1	ratio					598:602	the ratio	594:602	the ratio of villi height to crypt depth	594:633	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	2	73	theme	villi	607:611	arg1	height					583:588	significantly increased ileal villus height	546:588	significantly increased ileal villus height	546:588	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	8	74	theme	KEY	1787:1789	arg1	POINTS					1791:1796	KEY POINTS	1787:1796	KEY POINTS: • Chitosan-chelated zinc significantly modulated ileal microbiota.	1787:1864	KEY POINTS: • Chitosan-chelated zinc significantly modulated ileal microbiota.
34491402	6	75	theme	IGF-1	1395:1399	arg1	expression					1381:1390	the mRNA expression	1372:1390	the mRNA expression of IGF-1	1372:1399	In addition, the mRNA expression of IGF-1 was increased, the protein expression of occludin and claudin-1 was enhanced, while the mRNA expression of caspase 3 and caspase 8 was decreased in the CS-Zn group.
34491402	4	76	theme	lactate	903:909	arg1	concentrations					859:872	The concentrations	855:872	The concentrations of propionate, butyrate, and lactate in the CS-Zn group piglets	855:936	The concentrations of propionate, butyrate, and lactate in the CS-Zn group piglets were significantly increased, while the pH value was significantly decreased.
34491402	3	77	from	abundance	669:677	arg1	digesta					709:715	the ileal digesta	699:715	the ileal digesta	699:715	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	5	78	from	dose	1150:1153	arg1	ZnO					1189:1191	ZnO	1189:1191	ZnO	1189:1191	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	5	79	theme	TNF-α	1058:1062	arg1	concentrations					1033:1046	the concentrations	1029:1046	the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO)	1029:1192	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	5	79	theme	TNF-α	1058:1062	arg1	lower					1213:1217	lower	1213:1217	lower	1213:1217	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	1	80	theme	chitosan-chelated	205:221	arg1	zinc					223:226	chitosan-chelated zinc	205:226	chitosan-chelated zinc	205:226	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	3	81	theme	shigella	768:775	arg1	abundance					728:736	the abundance	724:736	the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6	724:824	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	1	82	from	microbiota	237:246	arg1	piglets					303:309	weaned piglets	296:309	weaned piglets challenged with Escherichia coli K88	296:346	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	5	83	theme	MPO	1065:1067	arg1	concentrations					1033:1046	the concentrations	1029:1046	the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO)	1029:1192	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	5	83	theme	MPO	1065:1067	arg1	lower					1213:1217	lower	1213:1217	lower	1213:1217	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	2	84	theme	villus	576:581	arg1	height					583:588	significantly increased ileal villus height	546:588	significantly increased ileal villus height	546:588	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	6	85	theme	claudin-1	1455:1463	arg1	expression					1428:1437	the protein expression	1416:1437	the protein expression of occludin and claudin-1	1416:1463	In addition, the mRNA expression of IGF-1 was increased, the protein expression of occludin and claudin-1 was enhanced, while the mRNA expression of caspase 3 and caspase 8 was decreased in the CS-Zn group.
34491402	2	86	theme	increased	560:568	arg1	height					583:588	significantly increased ileal villus height	546:588	significantly increased ileal villus height	546:588	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	9	87	theme	•	1866:1866	arg1	zinc					1886:1889	• Chitosan-chelated zinc	1866:1889	• Chitosan-chelated zinc	1866:1889	• Chitosan-chelated zinc can improve ileal health.
34491402	8	88	theme	ileal	1848:1852	arg1	microbiota					1854:1863	ileal microbiota	1848:1863	ileal microbiota	1848:1863	KEY POINTS: • Chitosan-chelated zinc significantly modulated ileal microbiota.
34491402	5	89	theme	IL-1β	1051:1055	arg1	concentrations					1033:1046	the concentrations	1029:1046	the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO)	1029:1192	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	5	89	theme	IL-1β	1051:1055	arg1	lower					1213:1217	lower	1213:1217	lower	1213:1217	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	6	90	theme	occludin	1442:1449	arg1	expression					1428:1437	the protein expression	1416:1437	the protein expression of occludin and claudin-1	1416:1463	In addition, the mRNA expression of IGF-1 was increased, the protein expression of occludin and claudin-1 was enhanced, while the mRNA expression of caspase 3 and caspase 8 was decreased in the CS-Zn group.
34491402	7	91	dep	Escherichia	1765:1775	arg1	coli					1777:1780	coli	1777:1780	coli	1777:1780	These results suggest CS-Zn treatment could help modulate the composition of ileal microbiota, attenuate inflammatory response, and maintain the intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	4	92	theme	group	924:928	arg1	piglets					930:936	the CS-Zn group piglets	914:936	the CS-Zn group piglets	914:936	The concentrations of propionate, butyrate, and lactate in the CS-Zn group piglets were significantly increased, while the pH value was significantly decreased.
34491402	0	93	theme	intestinal	84:93	arg1	function					95:102	intestinal function	84:102	intestinal function	84:102	Chitosan-chelated zinc modulates ileal microbiota, ileal microbial metabolites, and intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	5	94	theme	ileal	1087:1091	arg1	mucosa					1093:1098	the ileal mucosa	1083:1098	the ileal mucosa of the CS-Zn	1083:1111	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	2	95	theme	chitosan	487:494	arg1	treatment					496:504	the chitosan treatment	483:504	the chitosan treatment (CS, 766 mg chitosan/kg basal diet)	483:540	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	2	96	theme	chitosan/kg	518:528	arg1	diet					536:539	766 mg chitosan/kg basal diet	511:539	766 mg chitosan/kg basal diet	511:539	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	2	96	theme	chitosan/kg	518:528	arg1	CS					507:508	CS	507:508	CS	507:508	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	3	97	theme	sensu	810:814	arg1	stricto					816:822	Clostridium sensu stricto 6	798:824	Clostridium sensu stricto 6	798:824	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	10	98	theme	• The	1917:1921	arg1	microbiota					1929:1938	• The ileal microbiota	1917:1938	• The ileal microbiota	1917:1938	• The ileal microbiota plays an important role in host health.
34491402	1	99	theme	ileal	231:235	arg1	microbiota					237:246	ileal microbiota	231:246	ileal microbiota	231:246	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	2	100	contain	had	542:544	arg2	height					583:588	significantly increased ileal villus height	546:588	significantly increased ileal villus height	546:588	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	2	100	contain	had	542:544	arg1	Piglets					349:355	Piglets	349:355	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet)	349:540	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	2	100	contain	had	542:544	arg2	ratio					598:602	the ratio	594:602	the ratio of villi height to crypt depth	594:633	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	5	101	from	INF-γ	1074:1078	arg1	mucosa					1093:1098	the ileal mucosa	1083:1098	the ileal mucosa of the CS-Zn	1083:1111	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	6	102	theme	mRNA	1489:1492	arg1	expression					1494:1503	the mRNA expression	1485:1503	the mRNA expression of caspase 3 and caspase 8	1485:1530	In addition, the mRNA expression of IGF-1 was increased, the protein expression of occludin and claudin-1 was enhanced, while the mRNA expression of caspase 3 and caspase 8 was decreased in the CS-Zn group.
34491402	2	103	from	zinc	473:476	arg1	Cs-Zn					398:402	Cs-Zn	398:402	Cs-Zn	398:402	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	2	104	theme	treatment	387:395	arg1	Piglets					349:355	Piglets	349:355	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet)	349:540	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	0	105	theme	ileal	33:37	arg1	microbiota					39:48	ileal microbiota	33:48	ileal microbiota	33:48	Chitosan-chelated zinc modulates ileal microbiota, ileal microbial metabolites, and intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	5	106	theme	group	1127:1131	arg1	concentrations					1033:1046	the concentrations	1029:1046	the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO)	1029:1192	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	5	106	theme	group	1127:1131	arg1	lower					1213:1217	lower	1213:1217	lower	1213:1217	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	3	107	theme	CS-Zn	636:640	arg1	piglets					648:654	CS-Zn group piglets	636:654	CS-Zn group piglets	636:654	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	2	108	theme	chitosan/kg	426:436	arg1	diet					444:447	100 mg zinc + 766 mg chitosan/kg basal diet	405:447	100 mg zinc + 766 mg chitosan/kg basal diet	405:447	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	5	109	from	mucosa	1093:1098	arg1	concentrations					1033:1046	the concentrations	1029:1046	the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO)	1029:1192	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	5	109	from	mucosa	1093:1098	arg1	lower					1213:1217	lower	1213:1217	lower	1213:1217	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	1	110	theme	weaned	296:301	arg1	piglets					303:309	weaned piglets	296:309	weaned piglets challenged with Escherichia coli K88	296:346	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	4	111	theme	pH	978:979	arg1	value					981:985	the pH value	974:985	the pH value	974:985	The concentrations of propionate, butyrate, and lactate in the CS-Zn group piglets were significantly increased, while the pH value was significantly decreased.
34491402	2	112	theme	100 mg	405:410	arg1	diet					444:447	100 mg zinc + 766 mg chitosan/kg basal diet	405:447	100 mg zinc + 766 mg chitosan/kg basal diet	405:447	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	0	113	theme	microbial	57:65	arg1	metabolites					67:77	ileal microbial metabolites	51:77	ileal microbial metabolites	51:77	Chitosan-chelated zinc modulates ileal microbiota, ileal microbial metabolites, and intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	5	114	theme	CS-Zn	1107:1111	arg1	mucosa					1093:1098	the ileal mucosa	1083:1098	the ileal mucosa of the CS-Zn	1083:1111	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	2	115	dep	treatment	496:504	arg1	diet					536:539	766 mg chitosan/kg basal diet	511:539	766 mg chitosan/kg basal diet	511:539	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	2	115	dep	treatment	496:504	arg1	CS					507:508	CS	507:508	CS	507:508	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	0	116	theme	Escherichia	138:148	arg1	K88					155:157	Escherichia coli K88	138:157	Escherichia coli K88	138:157	Chitosan-chelated zinc modulates ileal microbiota, ileal microbial metabolites, and intestinal function in weaned piglets challenged with Escherichia coli K88.
34491402	6	117	theme	mRNA	1376:1379	arg1	expression					1381:1390	the mRNA expression	1372:1390	the mRNA expression of IGF-1	1372:1399	In addition, the mRNA expression of IGF-1 was increased, the protein expression of occludin and claudin-1 was enhanced, while the mRNA expression of caspase 3 and caspase 8 was decreased in the CS-Zn group.
34491402	1	118	theme	Escherichia	327:337	arg1	K88					344:346	Escherichia coli K88	327:346	Escherichia coli K88	327:346	This study was to investigate the effects of chitosan-chelated zinc on ileal microbiota, inflammatory response, and barrier function in weaned piglets challenged with Escherichia coli K88.
34491402	2	119	dep	treatment	387:395	arg1	Cs-Zn					398:402	Cs-Zn	398:402	Cs-Zn	398:402	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	5	120	theme	diet	1178:1181	arg1	dose					1150:1153	pharmacological dose	1134:1153	pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO	1134:1191	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	3	121	theme	Lactobacillus	682:694	arg1	abundance					669:677	a higher abundance	660:677	a higher abundance of Lactobacillus in the ileal digesta	660:715	CS-Zn group piglets had a higher abundance of Lactobacillus in the ileal digesta, while the abundance of Streptococcus, Escherichia shigella, Actinobacillus, and Clostridium sensu stricto 6 was significantly decreased.
34491402	2	122	dep	Cs-Zn	398:402	arg1	diet					444:447	100 mg zinc + 766 mg chitosan/kg basal diet	405:447	100 mg zinc + 766 mg chitosan/kg basal diet	405:447	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
34491402	5	123	theme	mRNA	1280:1283	arg1	expression					1285:1294	the mRNA expression	1276:1294	the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group	1276:1339	Furthermore, the concentrations of IL-1β, TNF-α, MPO, and INF-γ in the ileal mucosa of the CS-Zn and the H-ZnO group (pharmacological dose of 1600 mg Zn/kg basal diet, from ZnO) were significantly lower than those of the control group fed with basal diet, and the mRNA expression of TLR4, MyD88, and NF-κB of the CS-Zn group was also reduced.
34491402	2	124	theme	chitosan-chelated	364:380	arg1	treatment					387:395	the chitosan-chelated zinc treatment	360:395	the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc)	360:477	Piglets of the chitosan-chelated zinc treatment (Cs-Zn; 100 mg zinc + 766 mg chitosan/kg basal diet, from chitosan-chelated zinc) and the chitosan treatment (CS, 766 mg chitosan/kg basal diet) had significantly increased ileal villus height and the ratio of villi height to crypt depth.
32709341	10	0	from	concentrations	1527:1540	arg1	1-100 mg/mL					1555:1565	the range 1-100 mg/mL	1545:1565	the range 1-100 mg/mL	1545:1565	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	10	0	from	concentrations	1527:1540	arg1	holo-lactoferrin					1469:1484	Bovine holo-lactoferrin	1462:1484	Bovine holo-lactoferrin	1462:1484	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	10	0	from	concentrations	1527:1540	arg1	holo-transferrin					1497:1512	bovine holo-transferrin	1490:1512	bovine holo-transferrin	1490:1512	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	10	0	from	concentrations	1527:1540	arg1	proteins					1596:1603	target proteins	1589:1603	target proteins	1589:1603	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	10	1	theme	batch	1648:1652	arg1	conditions					1662:1671	batch binding conditions	1648:1671	batch binding conditions	1648:1671	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	5	2	theme	temperature	738:748	arg1	value					701:705	the value	697:705	the value of the lower critical solution temperature (LCST)	697:755	However, the value of the lower critical solution temperature (LCST) varied due to differences in co-polymer compositions.
32709341	6	3	theme	hydrophilic	892:902	arg1	moieties					904:911	more hydrophilic moieties	887:911	more hydrophilic moieties	887:911	In general, it was found that the LCST increased for co-polymers containing more hydrophilic moieties, but decreased for co-polymers with more hydrophobic moieties.
32709341	3	4	theme	polymerization	570:583	arg1	methods					585:591	free radical polymerization methods	557:591	free radical polymerization methods	557:591	Sixteen co-polymers of different compositions were synthesized by free radical polymerization methods.
32709341	8	5	theme	polymer	1229:1235	arg1	structures					1237:1246	the polymer structures	1225:1246	the polymer structures	1225:1246	When bulky side chains (octadecyl or triphenylmethyl groups) were located in the polymer structures the LCST transition was absent.
32709341	10	6	theme	polymer	1694:1700	arg1	sorbents					1732:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	1	7	theme	protein	312:318	arg1	conditions					328:337	different temperature and protein loading conditions	286:337	conditions	328:337	This study has examined the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials under different temperature and protein loading conditions.
32709341	12	8	theme	Sepharose	2162:2170	arg1	sorbents					2184:2191	negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents	2125:2191	negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents	2125:2191	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	1	9	theme	batch	180:184	arg1	behaviour					194:202	the batch binding behaviour	176:202	the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials	176:278	This study has examined the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials under different temperature and protein loading conditions.
32709341	6	10	theme	hydrophobic	954:964	arg1	moieties					966:973	more hydrophobic moieties	949:973	more hydrophobic moieties	949:973	In general, it was found that the LCST increased for co-polymers containing more hydrophilic moieties, but decreased for co-polymers with more hydrophobic moieties.
32709341	13	11	theme	copolymer	2451:2459	arg1	structure					2461:2469	the grafted copolymer structure	2439:2469	the grafted copolymer structure	2439:2469	Furthermore, the structure of the side chains present in the grafted copolymer structure was found to affect the adsorption performance of both proteins at 20 °C and 50 °C.
32709341	12	12	theme	surface	2285:2291	arg1	properties					2300:2309	the surface charge properties	2281:2309	the surface charge properties	2281:2309	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	10	13	theme	Fast	1722:1725	arg1	sorbents					1732:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	5	14	theme	critical	720:727	arg1	temperature					738:748	the lower critical solution temperature	710:748	the lower critical solution temperature (LCST)	710:755	However, the value of the lower critical solution temperature (LCST) varied due to differences in co-polymer compositions.
32709341	5	14	theme	critical	720:727	arg1	LCST					751:754	LCST	751:754	LCST	751:754	However, the value of the lower critical solution temperature (LCST) varied due to differences in co-polymer compositions.
32709341	2	15	theme	molecular	354:362	arg1	composition					364:374	molecular composition	354:374	molecular composition of poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers	354:433	The effect of molecular composition of poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers on the phase transition properties has been documented.
32709341	10	16	theme	bovine	1490:1495	arg1	proteins					1596:1603	target proteins	1589:1603	target proteins	1589:1603	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	10	16	theme	bovine	1490:1495	arg1	holo-transferrin					1497:1512	bovine holo-transferrin	1490:1512	bovine holo-transferrin	1490:1512	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	10	16	theme	bovine	1490:1495	arg1	holo-lactoferrin					1469:1484	Bovine holo-lactoferrin	1462:1484	Bovine holo-lactoferrin	1462:1484	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	10	17	theme	Sepharose	1710:1718	arg1	sorbents					1732:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	0	18	theme	protein	124:130	arg1	conditions					140:149	different temperature and protein loading conditions	98:149	conditions	140:149	Batch binding studies with thermo-responsive polymer grafted sepharose 6 fast flow sorbents under different temperature and protein loading conditions.
32709341	1	19	theme	different	207:215	arg1	materials					270:278	different thermo-responsive co-polymer grafted chromatographic materials	207:278	different thermo-responsive co-polymer grafted chromatographic materials	207:278	This study has examined the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials under different temperature and protein loading conditions.
32709341	8	20	dep	chains	1164:1169	arg1	octadecyl					1172:1180	octadecyl	1172:1180	octadecyl	1172:1180	When bulky side chains (octadecyl or triphenylmethyl groups) were located in the polymer structures the LCST transition was absent.
32709341	8	20	dep	chains	1164:1169	arg1	groups					1201:1206	triphenylmethyl groups	1185:1206	triphenylmethyl groups	1185:1206	When bulky side chains (octadecyl or triphenylmethyl groups) were located in the polymer structures the LCST transition was absent.
32709341	1	21	theme	co-polymer	235:244	arg1	materials					270:278	different thermo-responsive co-polymer grafted chromatographic materials	207:278	different thermo-responsive co-polymer grafted chromatographic materials	207:278	This study has examined the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials under different temperature and protein loading conditions.
32709341	12	22	theme	copolymer	2144:2152	arg1	sorbents					2184:2191	negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents	2125:2191	negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents	2125:2191	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	7	23	theme	branched	1079:1086	arg1	groups					1126:1131	N‑tert‑octyl groups	1113:1131	N‑tert‑octyl groups	1113:1131	Moreover, the LCST increased, together with increased width of the transition temperature, when highly branched monomeric moieties (i.e. N‑tert‑octyl groups) were present.
32709341	7	23	theme	branched	1079:1086	arg1	moieties					1098:1105	highly branched monomeric moieties	1072:1105	highly branched monomeric moieties (i.e. N‑tert‑octyl groups)	1072:1132	Moreover, the LCST increased, together with increased width of the transition temperature, when highly branched monomeric moieties (i.e. N‑tert‑octyl groups) were present.
32709341	13	24	theme	present	2428:2434	arg1	chains					2421:2426	the side chains	2412:2426	the side chains present in the grafted copolymer structure	2412:2469	Furthermore, the structure of the side chains present in the grafted copolymer structure was found to affect the adsorption performance of both proteins at 20 °C and 50 °C.
32709341	7	25	theme	N‑tert‑octyl	1113:1124	arg1	groups					1126:1131	N‑tert‑octyl groups	1113:1131	N‑tert‑octyl groups	1113:1131	Moreover, the LCST increased, together with increased width of the transition temperature, when highly branched monomeric moieties (i.e. N‑tert‑octyl groups) were present.
32709341	7	25	theme	N‑tert‑octyl	1113:1124	arg1	moieties					1098:1105	highly branched monomeric moieties	1072:1105	highly branched monomeric moieties (i.e. N‑tert‑octyl groups)	1072:1132	Moreover, the LCST increased, together with increased width of the transition temperature, when highly branched monomeric moieties (i.e. N‑tert‑octyl groups) were present.
32709341	9	26	theme	different	1340:1348	arg1	compositions					1350:1361	different compositions	1340:1361	different compositions	1340:1361	Based on these findings, 6 thermo-responsive co-polymers of different compositions were individually immobilised onto cross-linked Sepharose 6 Fast Flow by a "grafting-from" method.
32709341	7	27	theme	temperature	1054:1064	arg1	width					1030:1034	increased width	1020:1034	increased width of the transition temperature	1020:1064	Moreover, the LCST increased, together with increased width of the transition temperature, when highly branched monomeric moieties (i.e. N‑tert‑octyl groups) were present.
32709341	12	28	theme	opposite	2205:2212	arg1	trend					2214:2218	the opposite trend	2201:2218	the opposite trend	2201:2218	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	0	29	theme	flow	78:81	arg1	sorbents					83:90	sepharose 6 fast flow sorbents	61:90	sepharose 6 fast flow sorbents	61:90	Batch binding studies with thermo-responsive polymer grafted sepharose 6 fast flow sorbents under different temperature and protein loading conditions.
32709341	13	30	theme	side	2416:2419	arg1	chains					2421:2426	the side chains	2412:2426	the side chains present in the grafted copolymer structure	2412:2469	Furthermore, the structure of the side chains present in the grafted copolymer structure was found to affect the adsorption performance of both proteins at 20 °C and 50 °C.
32709341	9	31	theme	cross-linked	1398:1409	arg1	Flow					1428:1431	cross-linked Sepharose 6 Fast Flow	1398:1431	cross-linked Sepharose 6 Fast Flow	1398:1431	Based on these findings, 6 thermo-responsive co-polymers of different compositions were individually immobilised onto cross-linked Sepharose 6 Fast Flow by a "grafting-from" method.
32709341	8	32	located	located	1214:1220	arg1	structures					1237:1246	the polymer structures	1225:1246	the polymer structures	1225:1246	When bulky side chains (octadecyl or triphenylmethyl groups) were located in the polymer structures the LCST transition was absent.
32709341	8	32	located	located	1214:1220	arg2	chains					1164:1169	bulky side chains	1153:1169	bulky side chains (octadecyl or triphenylmethyl groups)	1153:1207	When bulky side chains (octadecyl or triphenylmethyl groups) were located in the polymer structures the LCST transition was absent.
32709341	12	33	dep	affinity	1921:1928	arg1	the					1917:1919	the	1917:1919	the	1917:1919	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	12	34	with	holo-lactoferrin	1964:1979	arg1	copolymer					2005:2013	positively charged copolymer	1986:2013	positively charged copolymer	1986:2013	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	12	35	theme	Fast	2035:2038	arg1	sorbents					2061:2068	Sepharose 6 Fast Flow chromatographic sorbents	2023:2068	Sepharose 6 Fast Flow chromatographic sorbents	2023:2068	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	9	36	link	cross-linked	1398:1409	arg1	Flow					1428:1431	cross-linked Sepharose 6 Fast Flow	1398:1431	cross-linked Sepharose 6 Fast Flow	1398:1431	Based on these findings, 6 thermo-responsive co-polymers of different compositions were individually immobilised onto cross-linked Sepharose 6 Fast Flow by a "grafting-from" method.
32709341	10	37	theme	different	1684:1692	arg1	sorbents					1732:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	12	38	theme	different	2348:2356	arg1	selectivity					2369:2379	different separation selectivity	2348:2379	different separation selectivity	2348:2379	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	2	39	theme	co-polymers	423:433	arg1	composition					364:374	molecular composition	354:374	molecular composition of poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers	354:433	The effect of molecular composition of poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers on the phase transition properties has been documented.
32709341	0	40	theme	Batch	0:4	arg1	studies					14:20	Batch binding studies	0:20	Batch binding studies with thermo-responsive polymer	0:51	Batch binding studies with thermo-responsive polymer grafted sepharose 6 fast flow sorbents under different temperature and protein loading conditions.
32709341	1	41	theme	loading	320:326	arg1	conditions					328:337	different temperature and protein loading conditions	286:337	conditions	328:337	This study has examined the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials under different temperature and protein loading conditions.
32709341	12	42	theme	chromatographic	2045:2059	arg1	sorbents					2061:2068	Sepharose 6 Fast Flow chromatographic sorbents	2023:2068	Sepharose 6 Fast Flow chromatographic sorbents	2023:2068	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	4	43	theme	phase	626:630	arg1	transitions					632:642	relatively sharp phase transitions	609:642	relatively sharp phase transitions	609:642	Most underwent relatively sharp phase transitions upon application of increasing temperature.
32709341	13	44	attach	present	2428:2434	arg1	structure					2461:2469	the grafted copolymer structure	2439:2469	the grafted copolymer structure	2439:2469	Furthermore, the structure of the side chains present in the grafted copolymer structure was found to affect the adsorption performance of both proteins at 20 °C and 50 °C.
32709341	13	44	attach	present	2428:2434	arg2	chains					2421:2426	the side chains	2412:2426	the side chains present in the grafted copolymer structure	2412:2469	Furthermore, the structure of the side chains present in the grafted copolymer structure was found to affect the adsorption performance of both proteins at 20 °C and 50 °C.
32709341	12	45	theme	selectivity	2369:2379	arg1	indicative					2334:2343	indicative	2334:2343	indicative	2334:2343	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	3	46	theme	different	514:522	arg1	compositions					524:535	different compositions	514:535	different compositions	514:535	Sixteen co-polymers of different compositions were synthesized by free radical polymerization methods.
32709341	8	47	theme	bulky	1153:1157	arg1	chains					1164:1169	bulky side chains	1153:1169	bulky side chains (octadecyl or triphenylmethyl groups)	1153:1207	When bulky side chains (octadecyl or triphenylmethyl groups) were located in the polymer structures the LCST transition was absent.
32709341	6	48	located	found	830:834	arg1	general					814:820	general	814:820	general	814:820	In general, it was found that the LCST increased for co-polymers containing more hydrophilic moieties, but decreased for co-polymers with more hydrophobic moieties.
32709341	6	48	located	found	830:834	arg2	it					823:824	it	823:824	it	823:824	In general, it was found that the LCST increased for co-polymers containing more hydrophilic moieties, but decreased for co-polymers with more hydrophobic moieties.
32709341	11	49	theme	adsorption	1828:1837	arg1	capacity					1839:1846	adsorption capacity	1828:1846	adsorption capacity	1828:1846	In general, all sorbents exhibited greater affinity and adsorption capacity for bovine holo-lactoferrin at 50 °C compared to 20 °C.
32709341	12	50	theme	proteins	2324:2331	arg1	properties					2300:2309	the surface charge properties	2281:2309	the surface charge properties	2281:2309	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	2	51	theme	transition	448:457	arg1	properties					459:468	the phase transition properties	438:468	the phase transition properties	438:468	The effect of molecular composition of poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers on the phase transition properties has been documented.
32709341	0	52	theme	thermo-responsive	27:43	arg1	polymer					45:51	thermo-responsive polymer	27:51	thermo-responsive polymer	27:51	Batch binding studies with thermo-responsive polymer grafted sepharose 6 fast flow sorbents under different temperature and protein loading conditions.
32709341	9	53	theme	grafting-from	1439:1451	arg1	method					1454:1459	a "grafting-from" method	1436:1459	a "grafting-from" method	1436:1459	Based on these findings, 6 thermo-responsive co-polymers of different compositions were individually immobilised onto cross-linked Sepharose 6 Fast Flow by a "grafting-from" method.
32709341	12	54	theme	indicative	2334:2343	arg1	properties					2300:2309	the surface charge properties	2281:2309	the surface charge properties	2281:2309	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	0	55	with	studies	14:20	arg1	polymer					45:51	thermo-responsive polymer	27:51	thermo-responsive polymer	27:51	Batch binding studies with thermo-responsive polymer grafted sepharose 6 fast flow sorbents under different temperature and protein loading conditions.
32709341	12	56	theme	holo-lactoferrin	1964:1979	arg1	affinity					1921:1928	affinity	1921:1928	affinity	1921:1928	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	12	56	theme	holo-lactoferrin	1964:1979	arg1	capacity					1945:1952	adsorption capacity	1934:1952	adsorption capacity	1934:1952	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	12	57	theme	bovine	1957:1962	arg1	holo-lactoferrin					1964:1979	bovine holo-lactoferrin	1957:1979	bovine holo-lactoferrin with positively charged copolymer	1957:2013	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	10	58	theme	adsorption	1621:1630	arg1	behaviour					1632:1640	the adsorption behaviour	1617:1640	the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents	1617:1739	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	1	59	theme	grafted	246:252	arg1	materials					270:278	different thermo-responsive co-polymer grafted chromatographic materials	207:278	different thermo-responsive co-polymer grafted chromatographic materials	207:278	This study has examined the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials under different temperature and protein loading conditions.
32709341	8	60	theme	triphenylmethyl	1185:1199	arg1	groups					1201:1206	triphenylmethyl groups	1185:1206	triphenylmethyl groups	1185:1206	When bulky side chains (octadecyl or triphenylmethyl groups) were located in the polymer structures the LCST transition was absent.
32709341	1	61	theme	materials	270:278	arg1	behaviour					194:202	the batch binding behaviour	176:202	the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials	176:278	This study has examined the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials under different temperature and protein loading conditions.
32709341	10	62	theme	binding	1654:1660	arg1	conditions					1662:1671	batch binding conditions	1648:1671	batch binding conditions	1648:1671	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	5	63	theme	solution	729:736	arg1	temperature					738:748	the lower critical solution temperature	710:748	the lower critical solution temperature (LCST)	710:755	However, the value of the lower critical solution temperature (LCST) varied due to differences in co-polymer compositions.
32709341	5	63	theme	solution	729:736	arg1	LCST					751:754	LCST	751:754	LCST	751:754	However, the value of the lower critical solution temperature (LCST) varied due to differences in co-polymer compositions.
32709341	3	64	theme	radical	562:568	arg1	methods					585:591	free radical polymerization methods	557:591	free radical polymerization methods	557:591	Sixteen co-polymers of different compositions were synthesized by free radical polymerization methods.
32709341	1	65	theme	different	286:294	arg1	temperature					296:306	different temperature and protein loading conditions	286:337	temperature	296:306	This study has examined the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials under different temperature and protein loading conditions.
32709341	12	66	theme	Flow	2179:2182	arg1	sorbents					2184:2191	negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents	2125:2191	negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents	2125:2191	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	10	67	theme	grafted	1702:1708	arg1	sorbents					1732:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	5	68	from	differences	771:781	arg1	compositions					797:808	co-polymer compositions	786:808	co-polymer compositions	786:808	However, the value of the lower critical solution temperature (LCST) varied due to differences in co-polymer compositions.
32709341	12	69	theme	charged	2136:2142	arg1	sorbents					2184:2191	negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents	2125:2191	negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents	2125:2191	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	7	70	dep	groups	1126:1131	arg1	i.e.					1108:1111	i.e.	1108:1111	i.e.	1108:1111	Moreover, the LCST increased, together with increased width of the transition temperature, when highly branched monomeric moieties (i.e. N‑tert‑octyl groups) were present.
32709341	10	71	theme	Bovine	1462:1467	arg1	holo-lactoferrin					1469:1484	Bovine holo-lactoferrin	1462:1484	Bovine holo-lactoferrin	1462:1484	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	10	71	theme	Bovine	1462:1467	arg1	holo-transferrin					1497:1512	bovine holo-transferrin	1490:1512	bovine holo-transferrin	1490:1512	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	10	71	theme	Bovine	1462:1467	arg1	proteins					1596:1603	target proteins	1589:1603	target proteins	1589:1603	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	12	72	theme	grafted	2154:2160	arg1	sorbents					2184:2191	negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents	2125:2191	negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents	2125:2191	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	10	73	theme	Flow	1727:1730	arg1	sorbents					1732:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	10	74	theme	different	1517:1525	arg1	concentrations					1527:1540	different concentrations	1517:1540	different concentrations in the range 1-100 mg/mL	1517:1565	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	2	75	theme	composition	364:374	arg1	effect					344:349	The effect	340:349	The effect of molecular composition of poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers on the phase transition properties	340:468	The effect of molecular composition of poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers on the phase transition properties has been documented.
32709341	1	76	theme	binding	186:192	arg1	behaviour					194:202	the batch binding behaviour	176:202	the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials	176:278	This study has examined the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials under different temperature and protein loading conditions.
32709341	8	77	theme	LCST	1252:1255	arg1	absent					1272:1277	absent	1272:1277	absent	1272:1277	When bulky side chains (octadecyl or triphenylmethyl groups) were located in the polymer structures the LCST transition was absent.
32709341	8	77	theme	LCST	1252:1255	arg1	transition					1257:1266	the LCST transition	1248:1266	the LCST transition	1248:1266	When bulky side chains (octadecyl or triphenylmethyl groups) were located in the polymer structures the LCST transition was absent.
32709341	0	78	theme	loading	132:138	arg1	conditions					140:149	different temperature and protein loading conditions	98:149	conditions	140:149	Batch binding studies with thermo-responsive polymer grafted sepharose 6 fast flow sorbents under different temperature and protein loading conditions.
32709341	13	79	from	present	2428:2434	arg1	structure					2461:2469	the grafted copolymer structure	2439:2469	the grafted copolymer structure	2439:2469	Furthermore, the structure of the side chains present in the grafted copolymer structure was found to affect the adsorption performance of both proteins at 20 °C and 50 °C.
32709341	13	80	theme	grafted	2443:2449	arg1	structure					2461:2469	the grafted copolymer structure	2439:2469	the grafted copolymer structure	2439:2469	Furthermore, the structure of the side chains present in the grafted copolymer structure was found to affect the adsorption performance of both proteins at 20 °C and 50 °C.
32709341	12	81	theme	bovine	2235:2240	arg1	holo-transferrin					2242:2257	bovine holo-transferrin	2235:2257	bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity	2235:2379	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	10	82	theme	different	1748:1756	arg1	temperatures					1758:1769	two different temperatures	1744:1769	two different temperatures	1744:1769	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	5	83	theme	co-polymer	786:795	arg1	compositions					797:808	co-polymer compositions	786:808	co-polymer compositions	786:808	However, the value of the lower critical solution temperature (LCST) varied due to differences in co-polymer compositions.
32709341	1	84	theme	thermo-responsive	217:233	arg1	materials					270:278	different thermo-responsive co-polymer grafted chromatographic materials	207:278	different thermo-responsive co-polymer grafted chromatographic materials	207:278	This study has examined the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials under different temperature and protein loading conditions.
32709341	12	85	theme	due	2259:2261	arg1	holo-transferrin					2242:2257	bovine holo-transferrin	2235:2257	bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity	2235:2379	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	9	86	theme	thermo-responsive	1307:1323	arg1	co-polymers					1325:1335	6 thermo-responsive co-polymers	1305:1335	6 thermo-responsive co-polymers of different compositions	1305:1361	Based on these findings, 6 thermo-responsive co-polymers of different compositions were individually immobilised onto cross-linked Sepharose 6 Fast Flow by a "grafting-from" method.
32709341	13	87	theme	chains	2421:2426	arg1	structure					2399:2407	the structure	2395:2407	the structure of the side chains present in the grafted copolymer structure	2395:2469	Furthermore, the structure of the side chains present in the grafted copolymer structure was found to affect the adsorption performance of both proteins at 20 °C and 50 °C.
32709341	7	88	theme	monomeric	1088:1096	arg1	groups					1126:1131	N‑tert‑octyl groups	1113:1131	N‑tert‑octyl groups	1113:1131	Moreover, the LCST increased, together with increased width of the transition temperature, when highly branched monomeric moieties (i.e. N‑tert‑octyl groups) were present.
32709341	7	88	theme	monomeric	1088:1096	arg1	moieties					1098:1105	highly branched monomeric moieties	1072:1105	highly branched monomeric moieties (i.e. N‑tert‑octyl groups)	1072:1132	Moreover, the LCST increased, together with increased width of the transition temperature, when highly branched monomeric moieties (i.e. N‑tert‑octyl groups) were present.
32709341	13	89	from	50 °C	2548:2552	arg1	performance					2506:2516	the adsorption performance	2491:2516	the adsorption performance of both proteins at 20 °C and 50 °C	2491:2552	Furthermore, the structure of the side chains present in the grafted copolymer structure was found to affect the adsorption performance of both proteins at 20 °C and 50 °C.
32709341	0	90	theme	fast	73:76	arg1	sorbents					83:90	sepharose 6 fast flow sorbents	61:90	sepharose 6 fast flow sorbents	61:90	Batch binding studies with thermo-responsive polymer grafted sepharose 6 fast flow sorbents under different temperature and protein loading conditions.
32709341	9	91	theme	compositions	1350:1361	arg1	co-polymers					1325:1335	6 thermo-responsive co-polymers	1305:1335	6 thermo-responsive co-polymers of different compositions	1305:1361	Based on these findings, 6 thermo-responsive co-polymers of different compositions were individually immobilised onto cross-linked Sepharose 6 Fast Flow by a "grafting-from" method.
32709341	6	92	contain	containing	876:885	arg2	moieties					904:911	more hydrophilic moieties	887:911	more hydrophilic moieties	887:911	In general, it was found that the LCST increased for co-polymers containing more hydrophilic moieties, but decreased for co-polymers with more hydrophobic moieties.
32709341	6	92	contain	containing	876:885	arg1	co-polymers					864:874	co-polymers	864:874	co-polymers containing more hydrophilic moieties	864:911	In general, it was found that the LCST increased for co-polymers containing more hydrophilic moieties, but decreased for co-polymers with more hydrophobic moieties.
32709341	2	93	from	effect	344:349	arg1	properties					459:468	the phase transition properties	438:468	the phase transition properties	438:468	The effect of molecular composition of poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers on the phase transition properties has been documented.
32709341	10	94	theme	range	1549:1553	arg1	1-100 mg/mL					1555:1565	the range 1-100 mg/mL	1545:1565	the range 1-100 mg/mL	1545:1565	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	0	95	theme	different	98:106	arg1	temperature					108:118	different temperature and protein loading conditions	98:149	temperature	108:118	Batch binding studies with thermo-responsive polymer grafted sepharose 6 fast flow sorbents under different temperature and protein loading conditions.
32709341	12	96	theme	charge	2293:2298	arg1	properties					2300:2309	the surface charge properties	2281:2309	the surface charge properties	2281:2309	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	7	97	theme	transition	1043:1052	arg1	temperature					1054:1064	the transition temperature	1039:1064	the transition temperature	1039:1064	Moreover, the LCST increased, together with increased width of the transition temperature, when highly branched monomeric moieties (i.e. N‑tert‑octyl groups) were present.
32709341	10	98	with	behaviour	1632:1640	arg1	sorbents					1732:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	these different polymer grafted Sepharose 6 Fast Flow sorbents	1678:1739	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	12	99	theme	Flow	2040:2043	arg1	sorbents					2061:2068	Sepharose 6 Fast Flow chromatographic sorbents	2023:2068	Sepharose 6 Fast Flow chromatographic sorbents	2023:2068	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	12	100	from	differences	2266:2276	arg1	properties					2300:2309	the surface charge properties	2281:2309	the surface charge properties	2281:2309	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	6	101	with	co-polymers	932:942	arg1	moieties					966:973	more hydrophobic moieties	949:973	more hydrophobic moieties	949:973	In general, it was found that the LCST increased for co-polymers containing more hydrophilic moieties, but decreased for co-polymers with more hydrophobic moieties.
32709341	0	102	theme	binding	6:12	arg1	studies					14:20	Batch binding studies	0:20	Batch binding studies with thermo-responsive polymer	0:51	Batch binding studies with thermo-responsive polymer grafted sepharose 6 fast flow sorbents under different temperature and protein loading conditions.
32709341	9	103	theme	Fast	1423:1426	arg1	Flow					1428:1431	cross-linked Sepharose 6 Fast Flow	1398:1431	cross-linked Sepharose 6 Fast Flow	1398:1431	Based on these findings, 6 thermo-responsive co-polymers of different compositions were individually immobilised onto cross-linked Sepharose 6 Fast Flow by a "grafting-from" method.
32709341	7	104	theme	increased	1020:1028	arg1	width					1030:1034	increased width	1020:1034	increased width of the transition temperature	1020:1064	Moreover, the LCST increased, together with increased width of the transition temperature, when highly branched monomeric moieties (i.e. N‑tert‑octyl groups) were present.
32709341	13	105	from	20 °C	2538:2542	arg1	performance					2506:2516	the adsorption performance	2491:2516	the adsorption performance of both proteins at 20 °C and 50 °C	2491:2552	Furthermore, the structure of the side chains present in the grafted copolymer structure was found to affect the adsorption performance of both proteins at 20 °C and 50 °C.
32709341	2	106	theme	-based	416:421	arg1	co-polymers					423:433	poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers	379:433	poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers	379:433	The effect of molecular composition of poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers on the phase transition properties has been documented.
32709341	8	107	theme	side	1159:1162	arg1	chains					1164:1169	bulky side chains	1153:1169	bulky side chains (octadecyl or triphenylmethyl groups)	1153:1207	When bulky side chains (octadecyl or triphenylmethyl groups) were located in the polymer structures the LCST transition was absent.
32709341	12	108	theme	separation	2358:2367	arg1	selectivity					2369:2379	different separation selectivity	2348:2379	different separation selectivity	2348:2379	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	3	109	theme	compositions	524:535	arg1	co-polymers					499:509	Sixteen co-polymers	491:509	Sixteen co-polymers of different compositions	491:535	Sixteen co-polymers of different compositions were synthesized by free radical polymerization methods.
32709341	8	110	from	located	1214:1220	arg1	structures					1237:1246	the polymer structures	1225:1246	the polymer structures	1225:1246	When bulky side chains (octadecyl or triphenylmethyl groups) were located in the polymer structures the LCST transition was absent.
32709341	13	111	theme	proteins	2526:2533	arg1	performance					2506:2516	the adsorption performance	2491:2516	the adsorption performance of both proteins at 20 °C and 50 °C	2491:2552	Furthermore, the structure of the side chains present in the grafted copolymer structure was found to affect the adsorption performance of both proteins at 20 °C and 50 °C.
32709341	10	112	theme	target	1589:1594	arg1	proteins					1596:1603	target proteins	1589:1603	target proteins	1589:1603	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	10	112	theme	target	1589:1594	arg1	holo-transferrin					1497:1512	bovine holo-transferrin	1490:1512	bovine holo-transferrin	1490:1512	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	10	112	theme	target	1589:1594	arg1	holo-lactoferrin					1469:1484	Bovine holo-lactoferrin	1462:1484	Bovine holo-lactoferrin	1462:1484	Bovine holo-lactoferrin and bovine holo-transferrin at different concentrations in the range 1-100 mg/mL were then employed as target proteins to evaluate the adsorption behaviour under batch binding conditions with these different polymer grafted Sepharose 6 Fast Flow sorbents at two different temperatures.
32709341	11	113	theme	greater	1807:1813	arg1	affinity					1815:1822	greater affinity	1807:1822	greater affinity	1807:1822	In general, all sorbents exhibited greater affinity and adsorption capacity for bovine holo-lactoferrin at 50 °C compared to 20 °C.
32709341	13	114	from	structure	2461:2469	arg1	present					2428:2434	present	2428:2434	present	2428:2434	Furthermore, the structure of the side chains present in the grafted copolymer structure was found to affect the adsorption performance of both proteins at 20 °C and 50 °C.
32709341	2	115	theme	phase	442:446	arg1	properties					459:468	the phase transition properties	438:468	the phase transition properties	438:468	The effect of molecular composition of poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers on the phase transition properties has been documented.
32709341	0	116	theme	sepharose	61:69	arg1	sorbents					83:90	sepharose 6 fast flow sorbents	61:90	sepharose 6 fast flow sorbents	61:90	Batch binding studies with thermo-responsive polymer grafted sepharose 6 fast flow sorbents under different temperature and protein loading conditions.
32709341	9	117	theme	"	1452:1452	arg1	method					1454:1459	a "grafting-from" method	1436:1459	a "grafting-from" method	1436:1459	Based on these findings, 6 thermo-responsive co-polymers of different compositions were individually immobilised onto cross-linked Sepharose 6 Fast Flow by a "grafting-from" method.
32709341	12	118	theme	adsorption	1934:1943	arg1	capacity					1945:1952	adsorption capacity	1934:1952	adsorption capacity	1934:1952	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	4	119	theme	sharp	620:624	arg1	transitions					632:642	relatively sharp phase transitions	609:642	relatively sharp phase transitions	609:642	Most underwent relatively sharp phase transitions upon application of increasing temperature.
32709341	11	120	theme	bovine	1852:1857	arg1	holo-lactoferrin					1859:1874	bovine holo-lactoferrin	1852:1874	bovine holo-lactoferrin	1852:1874	In general, all sorbents exhibited greater affinity and adsorption capacity for bovine holo-lactoferrin at 50 °C compared to 20 °C.
32709341	3	121	theme	free	557:560	arg1	methods					585:591	free radical polymerization methods	557:591	free radical polymerization methods	557:591	Sixteen co-polymers of different compositions were synthesized by free radical polymerization methods.
32709341	11	122	dep	exhibited	1797:1805	arg1	compared					1885:1892	compared	1885:1892	compared to 20 °C	1885:1901	In general, all sorbents exhibited greater affinity and adsorption capacity for bovine holo-lactoferrin at 50 °C compared to 20 °C.
32709341	12	123	theme	charged	1997:2003	arg1	copolymer					2005:2013	positively charged copolymer	1986:2013	positively charged copolymer	1986:2013	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
32709341	8	124	from	structures	1237:1246	arg1	located					1214:1220	located	1214:1220	located	1214:1220	When bulky side chains (octadecyl or triphenylmethyl groups) were located in the polymer structures the LCST transition was absent.
32709341	13	125	theme	adsorption	2495:2504	arg1	performance					2506:2516	the adsorption performance	2491:2516	the adsorption performance of both proteins at 20 °C and 50 °C	2491:2552	Furthermore, the structure of the side chains present in the grafted copolymer structure was found to affect the adsorption performance of both proteins at 20 °C and 50 °C.
32709341	2	126	dep	-based	416:421	arg1	N-isopropylacrylamide					384:404	N-isopropylacrylamide	384:404	N-isopropylacrylamide	384:404	The effect of molecular composition of poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers on the phase transition properties has been documented.
32709341	2	126	dep	-based	416:421	arg1	poly					379:382	poly	379:382	poly(N-isopropylacrylamide)	379:405	The effect of molecular composition of poly(N-isopropylacrylamide) (PNIPAAm)-based co-polymers on the phase transition properties has been documented.
32709341	1	127	theme	chromatographic	254:268	arg1	materials					270:278	different thermo-responsive co-polymer grafted chromatographic materials	207:278	different thermo-responsive co-polymer grafted chromatographic materials	207:278	This study has examined the batch binding behaviour of different thermo-responsive co-polymer grafted chromatographic materials under different temperature and protein loading conditions.
32709341	12	128	theme	Fast	2174:2177	arg1	sorbents					2184:2191	negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents	2125:2191	negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents	2125:2191	In addition, the affinity and adsorption capacity of bovine holo-lactoferrin with positively charged copolymer grafted Sepharose 6 Fast Flow chromatographic sorbents at 20 °C and 50 °C were much lower than that found for negatively charged copolymer grafted Sepharose 6 Fast Flow sorbents, whilst the opposite trend was found with bovine holo-transferrin due to differences in the surface charge properties of these two proteins, indicative of different separation selectivity.
34087300	0	0	theme	silica	112:117	arg1	nanoparticles					119:131	chitosan-decorated silica nanoparticles	93:131	chitosan-decorated silica nanoparticles	93:131	Fabrication and antibacterial evaluation of peppermint oil-loaded composite microcapsules by chitosan-decorated silica nanoparticles stabilized Pickering emulsion templating.
34087300	1	1	theme	PO	197:198	arg1	microcapsules					218:230	Novel peppermint oil (PO)-loaded composite microcapsules	175:230	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	175:301	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	1	1	theme	PO	197:198	arg1	CM					233:234	CM	233:234	CM	233:234	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	0	2	theme	chitosan-decorated	93:110	arg1	nanoparticles					119:131	chitosan-decorated silica nanoparticles	93:131	chitosan-decorated silica nanoparticles	93:131	Fabrication and antibacterial evaluation of peppermint oil-loaded composite microcapsules by chitosan-decorated silica nanoparticles stabilized Pickering emulsion templating.
34087300	4	3	with	microcapsules	786:798	arg1	%					808:808	100%	805:808	100%	805:808	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	4	4	theme	prolonged	895:903	arg1	release					905:911	the prolonged release	891:911	the prolonged release	891:911	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	4	5	theme	peppermint	754:763	arg1	microcapsules					786:798	The peppermint oil-loaded composite microcapsules	750:798	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC)	750:847	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	4	5	theme	peppermint	754:763	arg1	formulation					870:880	optimum formulation	862:880	optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%)	862:978	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	1	6	theme	/chitosan/silica	279:294	arg1	shells					296:301	hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	242:301	hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	242:301	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	2	7	theme	PO	582:583	arg1	emulsions					595:603	PO Pickering emulsions	582:603	PO Pickering emulsions	582:603	The surface modification of chitosan could improve the hydrophobicity of silica nanoparticles and favor their adsorption at the oil-water interface of PO Pickering emulsions.
34087300	1	8	theme	chitosan-decorated	384:401	arg1	nanoparticles					410:422	chitosan-decorated silica nanoparticles	384:422	chitosan-decorated silica nanoparticles (CSN)	384:428	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	1	8	theme	chitosan-decorated	384:401	arg1	CSN					425:427	CSN	425:427	CSN	425:427	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	4	9	theme	acceptable	914:923	arg1	efficiency					936:945	acceptable entrapment efficiency	914:945	acceptable entrapment efficiency (89.1%)	914:953	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	4	9	theme	acceptable	914:923	arg1	%					952:952	89.1%	948:952	89.1%	948:952	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	5	10	theme	100	991:993	arg1	%					994:994	%	994:994	%	994:994	The PO-CM@100%HPMC could remarkably prolong the stability of PO.
34087300	7	11	theme	Pickering	1199:1207	arg1	emulsions					1209:1217	the Pickering emulsions	1195:1217	the Pickering emulsions based	1195:1223	Therefore, the Pickering emulsions based microcapsules seemed to be a promising strategy for antibacterial application for PO.
34087300	7	11	theme	Pickering	1199:1207	arg1	strategy					1264:1271	a promising strategy	1252:1271	a promising strategy for antibacterial application for PO	1252:1308	Therefore, the Pickering emulsions based microcapsules seemed to be a promising strategy for antibacterial application for PO.
34087300	1	12	theme	silica	403:408	arg1	nanoparticles					410:422	chitosan-decorated silica nanoparticles	384:422	chitosan-decorated silica nanoparticles (CSN)	384:428	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	1	12	theme	silica	403:408	arg1	CSN					425:427	CSN	425:427	CSN	425:427	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	4	13	theme	oil-loaded	765:774	arg1	microcapsules					786:798	The peppermint oil-loaded composite microcapsules	750:798	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC)	750:847	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	4	13	theme	oil-loaded	765:774	arg1	formulation					870:880	optimum formulation	862:880	optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%)	862:978	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	0	14	theme	emulsion	154:161	arg1	templating					163:172	Pickering emulsion templating	144:172	Pickering emulsion templating	144:172	Fabrication and antibacterial evaluation of peppermint oil-loaded composite microcapsules by chitosan-decorated silica nanoparticles stabilized Pickering emulsion templating.
34087300	6	15	theme	PO-CM	1060:1064	arg1	%					1069:1069	the PO-CM@100%HPMC	1056:1073	the PO-CM@100%HPMC	1056:1073	Moreover, the PO-CM@100%HPMC had a long-term antimicrobial activity (85.4%) against S. aureus and E. coli even after storage for 60 days.
34087300	4	16	theme	@	838:838	arg1	HPMC					843:846	PO-CM@100%HPMC	833:846	PO-CM@100%HPMC	833:846	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	4	16	theme	@	838:838	arg1	material					823:830	wall material	818:830	wall material (PO-CM@100%HPMC)	818:847	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	1	17	theme	-loaded	200:206	arg1	microcapsules					218:230	Novel peppermint oil (PO)-loaded composite microcapsules	175:230	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	175:301	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	1	17	theme	-loaded	200:206	arg1	CM					233:234	CM	233:234	CM	233:234	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	0	18	theme	Pickering	144:152	arg1	templating					163:172	Pickering emulsion templating	144:172	Pickering emulsion templating	144:172	Fabrication and antibacterial evaluation of peppermint oil-loaded composite microcapsules by chitosan-decorated silica nanoparticles stabilized Pickering emulsion templating.
34087300	4	19	theme	PO-CM	833:837	arg1	HPMC					843:846	PO-CM@100%HPMC	833:846	PO-CM@100%HPMC	833:846	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	4	19	theme	PO-CM	833:837	arg1	material					823:830	wall material	818:830	wall material (PO-CM@100%HPMC)	818:847	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	6	20	theme	@	1065:1065	arg1	%					1069:1069	the PO-CM@100%HPMC	1056:1073	the PO-CM@100%HPMC	1056:1073	Moreover, the PO-CM@100%HPMC had a long-term antimicrobial activity (85.4%) against S. aureus and E. coli even after storage for 60 days.
34087300	1	21	theme	composite	208:216	arg1	microcapsules					218:230	Novel peppermint oil (PO)-loaded composite microcapsules	175:230	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	175:301	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	1	21	theme	composite	208:216	arg1	CM					233:234	CM	233:234	CM	233:234	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	4	22	theme	wall	818:821	arg1	HPMC					843:846	PO-CM@100%HPMC	833:846	PO-CM@100%HPMC	833:846	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	4	22	theme	wall	818:821	arg1	material					823:830	wall material	818:830	wall material (PO-CM@100%HPMC)	818:847	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	7	23	theme	promising	1254:1262	arg1	strategy					1264:1271	a promising strategy	1252:1271	a promising strategy for antibacterial application for PO	1252:1308	Therefore, the Pickering emulsions based microcapsules seemed to be a promising strategy for antibacterial application for PO.
34087300	7	23	theme	promising	1254:1262	arg1	emulsions					1209:1217	the Pickering emulsions	1195:1217	the Pickering emulsions based	1195:1223	Therefore, the Pickering emulsions based microcapsules seemed to be a promising strategy for antibacterial application for PO.
34087300	4	24	theme	drug	959:962	arg1	loading					964:970	drug loading	959:970	drug loading (25.5%)	959:978	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	4	24	theme	drug	959:962	arg1	%					977:977	25.5%	973:977	25.5%	973:977	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	2	25	from	interface	569:577	arg1	adsorption					541:550	their adsorption	535:550	their adsorption at the oil-water interface of PO Pickering emulsions	535:603	The surface modification of chitosan could improve the hydrophobicity of silica nanoparticles and favor their adsorption at the oil-water interface of PO Pickering emulsions.
34087300	2	26	mod	modification	443:454	arg1	chitosan					459:466	chitosan	459:466	chitosan	459:466	The surface modification of chitosan could improve the hydrophobicity of silica nanoparticles and favor their adsorption at the oil-water interface of PO Pickering emulsions.
34087300	2	26	mod	modification	443:454	arg3	surface					435:441	The surface modification	431:454	The surface modification of chitosan	431:466	The surface modification of chitosan could improve the hydrophobicity of silica nanoparticles and favor their adsorption at the oil-water interface of PO Pickering emulsions.
34087300	5	27	theme	%	994:994	arg1	HPMC					995:998	The PO-CM@100%HPMC	981:998	The PO-CM@100%HPMC	981:998	The PO-CM@100%HPMC could remarkably prolong the stability of PO.
34087300	3	28	theme	microcapsule	610:621	arg1	shells					633:638	The microcapsule composite shells	606:638	The microcapsule composite shells	606:638	The microcapsule composite shells were formed dependent on the electrostatic adsorption of HPMC and CSN, and further subjected to spray-drying.
34087300	0	29	theme	antibacterial	16:28	arg1	evaluation					30:39	antibacterial evaluation	16:39	antibacterial evaluation	16:39	Fabrication and antibacterial evaluation of peppermint oil-loaded composite microcapsules by chitosan-decorated silica nanoparticles stabilized Pickering emulsion templating.
34087300	6	30	contain	had	1075:1077	arg1	%					1069:1069	the PO-CM@100%HPMC	1056:1073	the PO-CM@100%HPMC	1056:1073	Moreover, the PO-CM@100%HPMC had a long-term antimicrobial activity (85.4%) against S. aureus and E. coli even after storage for 60 days.
34087300	6	30	contain	had	1075:1077	arg2	activity					1105:1112	a long-term antimicrobial activity	1079:1112	a long-term antimicrobial activity (85.4%) against S. aureus and E. coli	1079:1150	Moreover, the PO-CM@100%HPMC had a long-term antimicrobial activity (85.4%) against S. aureus and E. coli even after storage for 60 days.
34087300	6	30	contain	had	1075:1077	arg2	%					1119:1119	85.4%	1115:1119	85.4%	1115:1119	Moreover, the PO-CM@100%HPMC had a long-term antimicrobial activity (85.4%) against S. aureus and E. coli even after storage for 60 days.
34087300	3	31	theme	composite	623:631	arg1	shells					633:638	The microcapsule composite shells	606:638	The microcapsule composite shells	606:638	The microcapsule composite shells were formed dependent on the electrostatic adsorption of HPMC and CSN, and further subjected to spray-drying.
34087300	2	32	theme	nanoparticles	511:523	arg1	hydrophobicity					486:499	the hydrophobicity	482:499	the hydrophobicity of silica nanoparticles	482:523	The surface modification of chitosan could improve the hydrophobicity of silica nanoparticles and favor their adsorption at the oil-water interface of PO Pickering emulsions.
34087300	2	33	theme	chitosan	459:466	arg1	modification					443:454	The surface modification	431:454	The surface modification of chitosan	431:466	The surface modification of chitosan could improve the hydrophobicity of silica nanoparticles and favor their adsorption at the oil-water interface of PO Pickering emulsions.
34087300	0	34	theme	peppermint	44:53	arg1	microcapsules					76:88	peppermint oil-loaded composite microcapsules	44:88	peppermint oil-loaded composite microcapsules	44:88	Fabrication and antibacterial evaluation of peppermint oil-loaded composite microcapsules by chitosan-decorated silica nanoparticles stabilized Pickering emulsion templating.
34087300	1	35	theme	PO	334:335	arg1	emulsion					347:354	PO Pickering emulsion	334:354	PO Pickering emulsion	334:354	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	2	36	theme	emulsions	595:603	arg1	interface					569:577	the oil-water interface	555:577	the oil-water interface of PO Pickering emulsions	555:603	The surface modification of chitosan could improve the hydrophobicity of silica nanoparticles and favor their adsorption at the oil-water interface of PO Pickering emulsions.
34087300	6	37	theme	long-term	1081:1089	arg1	activity					1105:1112	a long-term antimicrobial activity	1079:1112	a long-term antimicrobial activity (85.4%) against S. aureus and E. coli	1079:1150	Moreover, the PO-CM@100%HPMC had a long-term antimicrobial activity (85.4%) against S. aureus and E. coli even after storage for 60 days.
34087300	6	37	theme	long-term	1081:1089	arg1	%					1119:1119	85.4%	1115:1119	85.4%	1115:1119	Moreover, the PO-CM@100%HPMC had a long-term antimicrobial activity (85.4%) against S. aureus and E. coli even after storage for 60 days.
34087300	2	38	theme	surface	435:441	arg1	modification					443:454	The surface modification	431:454	The surface modification of chitosan	431:466	The surface modification of chitosan could improve the hydrophobicity of silica nanoparticles and favor their adsorption at the oil-water interface of PO Pickering emulsions.
34087300	1	39	theme	Pickering	337:345	arg1	emulsion					347:354	PO Pickering emulsion	334:354	PO Pickering emulsion	334:354	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	2	40	theme	Pickering	585:593	arg1	emulsions					595:603	PO Pickering emulsions	582:603	PO Pickering emulsions	582:603	The surface modification of chitosan could improve the hydrophobicity of silica nanoparticles and favor their adsorption at the oil-water interface of PO Pickering emulsions.
34087300	1	41	theme	hydroxypropyl	242:254	arg1	shells					296:301	hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	242:301	hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	242:301	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	0	42	theme	composite	66:74	arg1	microcapsules					76:88	peppermint oil-loaded composite microcapsules	44:88	peppermint oil-loaded composite microcapsules	44:88	Fabrication and antibacterial evaluation of peppermint oil-loaded composite microcapsules by chitosan-decorated silica nanoparticles stabilized Pickering emulsion templating.
34087300	1	43	with	microcapsules	218:230	arg1	shells					296:301	hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	242:301	hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	242:301	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	3	44	theme	CSN	706:708	arg1	adsorption					683:692	the electrostatic adsorption	665:692	the electrostatic adsorption of HPMC and CSN	665:708	The microcapsule composite shells were formed dependent on the electrostatic adsorption of HPMC and CSN, and further subjected to spray-drying.
34087300	4	45	theme	optimum	862:868	arg1	microcapsules					786:798	The peppermint oil-loaded composite microcapsules	750:798	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC)	750:847	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	4	45	theme	optimum	862:868	arg1	formulation					870:880	optimum formulation	862:880	optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%)	862:978	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	6	46	theme	HPMC	1070:1073	arg1	%					1069:1069	the PO-CM@100%HPMC	1056:1073	the PO-CM@100%HPMC	1056:1073	Moreover, the PO-CM@100%HPMC had a long-term antimicrobial activity (85.4%) against S. aureus and E. coli even after storage for 60 days.
34087300	6	47	theme	antimicrobial	1091:1103	arg1	activity					1105:1112	a long-term antimicrobial activity	1079:1112	a long-term antimicrobial activity (85.4%) against S. aureus and E. coli	1079:1150	Moreover, the PO-CM@100%HPMC had a long-term antimicrobial activity (85.4%) against S. aureus and E. coli even after storage for 60 days.
34087300	6	47	theme	antimicrobial	1091:1103	arg1	%					1119:1119	85.4%	1115:1119	85.4%	1115:1119	Moreover, the PO-CM@100%HPMC had a long-term antimicrobial activity (85.4%) against S. aureus and E. coli even after storage for 60 days.
34087300	0	48	theme	oil-loaded	55:64	arg1	microcapsules					76:88	peppermint oil-loaded composite microcapsules	44:88	peppermint oil-loaded composite microcapsules	44:88	Fabrication and antibacterial evaluation of peppermint oil-loaded composite microcapsules by chitosan-decorated silica nanoparticles stabilized Pickering emulsion templating.
34087300	4	49	theme	entrapment	925:934	arg1	efficiency					936:945	acceptable entrapment efficiency	914:945	acceptable entrapment efficiency (89.1%)	914:953	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	4	49	theme	entrapment	925:934	arg1	%					952:952	89.1%	948:952	89.1%	948:952	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	2	50	theme	silica	504:509	arg1	nanoparticles					511:523	silica nanoparticles	504:523	silica nanoparticles	504:523	The surface modification of chitosan could improve the hydrophobicity of silica nanoparticles and favor their adsorption at the oil-water interface of PO Pickering emulsions.
34087300	4	51	theme	composite	776:784	arg1	microcapsules					786:798	The peppermint oil-loaded composite microcapsules	750:798	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC)	750:847	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	4	51	theme	composite	776:784	arg1	formulation					870:880	optimum formulation	862:880	optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%)	862:978	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	5	52	theme	@	990:990	arg1	HPMC					995:998	The PO-CM@100%HPMC	981:998	The PO-CM@100%HPMC	981:998	The PO-CM@100%HPMC could remarkably prolong the stability of PO.
34087300	4	53	theme	%	842:842	arg1	HPMC					843:846	PO-CM@100%HPMC	833:846	PO-CM@100%HPMC	833:846	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	4	53	theme	%	842:842	arg1	material					823:830	wall material	818:830	wall material (PO-CM@100%HPMC)	818:847	The peppermint oil-loaded composite microcapsules with 100% HPMC as wall material (PO-CM@100%HPMC) seemed to be optimum formulation based on the prolonged release, acceptable entrapment efficiency (89.1%) and drug loading (25.5%).
34087300	1	54	theme	Novel	175:179	arg1	microcapsules					218:230	Novel peppermint oil (PO)-loaded composite microcapsules	175:230	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	175:301	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	1	54	theme	Novel	175:179	arg1	CM					233:234	CM	233:234	CM	233:234	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	2	55	theme	oil-water	559:567	arg1	interface					569:577	the oil-water interface	555:577	the oil-water interface of PO Pickering emulsions	555:603	The surface modification of chitosan could improve the hydrophobicity of silica nanoparticles and favor their adsorption at the oil-water interface of PO Pickering emulsions.
34087300	1	56	theme	methyl	256:261	arg1	shells					296:301	hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	242:301	hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	242:301	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	5	57	theme	PO-CM	985:989	arg1	HPMC					995:998	The PO-CM@100%HPMC	981:998	The PO-CM@100%HPMC	981:998	The PO-CM@100%HPMC could remarkably prolong the stability of PO.
34087300	5	58	theme	PO	1042:1043	arg1	stability					1029:1037	the stability	1025:1037	the stability of PO	1025:1043	The PO-CM@100%HPMC could remarkably prolong the stability of PO.
34087300	3	59	theme	HPMC	697:700	arg1	adsorption					683:692	the electrostatic adsorption	665:692	the electrostatic adsorption of HPMC and CSN	665:708	The microcapsule composite shells were formed dependent on the electrostatic adsorption of HPMC and CSN, and further subjected to spray-drying.
34087300	1	60	theme	peppermint	181:190	arg1	microcapsules					218:230	Novel peppermint oil (PO)-loaded composite microcapsules	175:230	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	175:301	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	1	60	theme	peppermint	181:190	arg1	CM					233:234	CM	233:234	CM	233:234	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	1	61	theme	cellulose	263:271	arg1	shells					296:301	hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	242:301	hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	242:301	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	3	62	theme	electrostatic	669:681	arg1	adsorption					683:692	the electrostatic adsorption	665:692	the electrostatic adsorption of HPMC and CSN	665:708	The microcapsule composite shells were formed dependent on the electrostatic adsorption of HPMC and CSN, and further subjected to spray-drying.
34087300	1	63	theme	oil	192:194	arg1	microcapsules					218:230	Novel peppermint oil (PO)-loaded composite microcapsules	175:230	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	175:301	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	1	63	theme	oil	192:194	arg1	CM					233:234	CM	233:234	CM	233:234	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
34087300	7	64	theme	antibacterial	1277:1289	arg1	application					1291:1301	antibacterial application	1277:1301	antibacterial application for PO	1277:1308	Therefore, the Pickering emulsions based microcapsules seemed to be a promising strategy for antibacterial application for PO.
34087300	0	65	theme	microcapsules	76:88	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication	0:10	Fabrication and antibacterial evaluation of peppermint oil-loaded composite microcapsules by chitosan-decorated silica nanoparticles stabilized Pickering emulsion templating.
34087300	0	65	theme	microcapsules	76:88	arg1	evaluation					30:39	antibacterial evaluation	16:39	antibacterial evaluation	16:39	Fabrication and antibacterial evaluation of peppermint oil-loaded composite microcapsules by chitosan-decorated silica nanoparticles stabilized Pickering emulsion templating.
34087300	1	66	theme	HPMC	274:277	arg1	shells					296:301	hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	242:301	hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells	242:301	Novel peppermint oil (PO)-loaded composite microcapsules (CM) with hydroxypropyl methyl cellulose (HPMC)/chitosan/silica shells were effectively fabricated by PO Pickering emulsion, which were stabilized with chitosan-decorated silica nanoparticles (CSN).
33525731	5	0	with	composite	981:989	arg1	loading					1003:1009	10 phr loading	996:1009	10 phr loading of α-cellulose	996:1024	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	6	1	theme	synthetic	1090:1098	arg1	filler					1100:1105	synthetic filler	1090:1105	synthetic filler (silica)	1090:1114	With this background, synthetic filler (silica) is substituted by green filler (α-cellulose) in an E-SBR-based composite.
33525731	6	1	theme	synthetic	1090:1098	arg1	silica					1108:1113	silica	1108:1113	silica	1108:1113	With this background, synthetic filler (silica) is substituted by green filler (α-cellulose) in an E-SBR-based composite.
33525731	0	2	theme	E-SBR	75:79	arg1	Composite					81:89	an E-SBR Composite	72:89	an E-SBR Composite	72:89	Morphology and Physico-Mechanical Threshold of α-Cellulose as Filler in an E-SBR Composite.
33525731	4	3	theme	dynamic-mechanical	667:684	arg1	behavior					686:693	Rheological, physical, visco-elastic and dynamic-mechanical behavior	626:693	Rheological, physical, visco-elastic and dynamic-mechanical behavior	626:693	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	1	4	theme	significant	228:238	arg1	recognition					240:250	significant recognition	228:250	significant recognition	228:250	In the current context of green mobility and sustainability, the use of new generation natural fillers, namely, α-cellulose, has gained significant recognition.
33525731	5	5	theme	α-cellulose	1014:1024	arg1	loading					1003:1009	10 phr loading	996:1009	10 phr loading of α-cellulose	996:1024	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	2	6	theme	hydroxyl	269:276	arg1	groups					278:283	hydroxyl groups	269:283	hydroxyl groups	269:283	The presence of hydroxyl groups on α-cellulose has generated immense eagerness to map its potency as filler in an elastomeric composite.
33525731	1	7	theme	current	99:105	arg1	context					107:113	the current context	95:113	the current context of green mobility and sustainability	95:150	In the current context of green mobility and sustainability, the use of new generation natural fillers, namely, α-cellulose, has gained significant recognition.
33525731	5	8	theme	electron	931:938	arg1	TEM					952:954	TEM	952:954	TEM	952:954	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	5	8	theme	electron	931:938	arg1	microscopy					940:949	transmission electron microscopy	918:949	transmission electron microscopy (TEM)	918:955	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	0	9	from	Filler	62:67	arg1	Composite					81:89	an E-SBR Composite	72:89	an E-SBR Composite	72:89	Morphology and Physico-Mechanical Threshold of α-Cellulose as Filler in an E-SBR Composite.
33525731	4	10	theme	α-cellulose	743:753	arg1	loading					732:738	10 phr loading	725:738	10 phr loading of α-cellulose	725:753	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	4	10	theme	α-cellulose	743:753	arg1	dosage					789:794	an optimized dosage	776:794	an optimized dosage in terms of performance parameters	776:829	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	5	11	theme	transmission	918:929	arg1	TEM					952:954	TEM	952:954	TEM	952:954	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	5	11	theme	transmission	918:929	arg1	microscopy					940:949	transmission electron microscopy	918:949	transmission electron microscopy (TEM)	918:955	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	3	12	theme	processing	516:525	arg1	method					527:532	conventional rubber processing method	496:532	conventional rubber processing method	496:532	In the present work, α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite is prepared by conventional rubber processing method by using variable proportions of α-cellulose (1 to 40 phr) to assess its reinforce ability.
33525731	3	13	theme	present	397:403	arg1	work					405:408	the present work	393:408	the present work	393:408	In the present work, α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite is prepared by conventional rubber processing method by using variable proportions of α-cellulose (1 to 40 phr) to assess its reinforce ability.
33525731	2	14	theme	elastomeric	367:377	arg1	composite					379:387	an elastomeric composite	364:387	an elastomeric composite	364:387	The presence of hydroxyl groups on α-cellulose has generated immense eagerness to map its potency as filler in an elastomeric composite.
33525731	4	15	theme	parameters	820:829	arg1	terms					799:803	terms	799:803	terms of performance parameters	799:829	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	3	16	theme	α-cellulose-emulsion-grade	411:436	arg1	composite					471:479	α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite	411:479	α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite	411:479	In the present work, α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite is prepared by conventional rubber processing method by using variable proportions of α-cellulose (1 to 40 phr) to assess its reinforce ability.
33525731	7	17	theme	reinforcement	1251:1263	arg1	ability					1265:1271	the reinforcement ability	1247:1271	the reinforcement ability of α-cellulose	1247:1286	Characterization of the compound has clearly established the reinforcement ability of α-cellulose.
33525731	4	18	theme	phr	728:730	arg1	loading					732:738	10 phr loading	725:738	10 phr loading of α-cellulose	725:753	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	4	18	theme	phr	728:730	arg1	dosage					789:794	an optimized dosage	776:794	an optimized dosage in terms of performance parameters	776:829	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	1	19	theme	new	164:166	arg1	fillers					187:193	new generation natural fillers	164:193	new generation natural fillers	164:193	In the current context of green mobility and sustainability, the use of new generation natural fillers, namely, α-cellulose, has gained significant recognition.
33525731	1	19	theme	new	164:166	arg1	α-cellulose					204:214	α-cellulose	204:214	α-cellulose	204:214	In the current context of green mobility and sustainability, the use of new generation natural fillers, namely, α-cellulose, has gained significant recognition.
33525731	3	20	theme	α-cellulose	567:577	arg1	proportions					552:562	variable proportions	543:562	variable proportions of α-cellulose (1 to 40 phr)	543:591	In the present work, α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite is prepared by conventional rubber processing method by using variable proportions of α-cellulose (1 to 40 phr) to assess its reinforce ability.
33525731	1	21	theme	generation	168:177	arg1	fillers					187:193	new generation natural fillers	164:193	new generation natural fillers	164:193	In the current context of green mobility and sustainability, the use of new generation natural fillers, namely, α-cellulose, has gained significant recognition.
33525731	1	21	theme	generation	168:177	arg1	α-cellulose					204:214	α-cellulose	204:214	α-cellulose	204:214	In the current context of green mobility and sustainability, the use of new generation natural fillers, namely, α-cellulose, has gained significant recognition.
33525731	4	22	theme	10	725:726	arg1	phr					728:730	phr	728:730	phr	728:730	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	5	23	dep	the	868:870	arg1	aid					872:874	aid	872:874	aid	872:874	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	3	24	theme	variable	543:550	arg1	proportions					552:562	variable proportions	543:562	variable proportions of α-cellulose (1 to 40 phr)	543:591	In the present work, α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite is prepared by conventional rubber processing method by using variable proportions of α-cellulose (1 to 40 phr) to assess its reinforce ability.
33525731	1	25	theme	natural	179:185	arg1	fillers					187:193	new generation natural fillers	164:193	new generation natural fillers	164:193	In the current context of green mobility and sustainability, the use of new generation natural fillers, namely, α-cellulose, has gained significant recognition.
33525731	1	25	theme	natural	179:185	arg1	α-cellulose					204:214	α-cellulose	204:214	α-cellulose	204:214	In the current context of green mobility and sustainability, the use of new generation natural fillers, namely, α-cellulose, has gained significant recognition.
33525731	0	26	theme	Physico-Mechanical	15:32	arg1	Threshold					34:42	Physico-Mechanical Threshold	15:42	Physico-Mechanical Threshold	15:42	Morphology and Physico-Mechanical Threshold of α-Cellulose as Filler in an E-SBR Composite.
33525731	5	27	with	characterization	846:861	arg1	the					868:870	the	868:870	the	868:870	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	6	28	theme	E-SBR-based	1167:1177	arg1	composite					1179:1187	an E-SBR-based composite	1164:1187	an E-SBR-based composite	1164:1187	With this background, synthetic filler (silica) is substituted by green filler (α-cellulose) in an E-SBR-based composite.
33525731	2	29	theme	groups	278:283	arg1	presence					257:264	The presence	253:264	The presence of hydroxyl groups on α-cellulose	253:298	The presence of hydroxyl groups on α-cellulose has generated immense eagerness to map its potency as filler in an elastomeric composite.
33525731	1	30	theme	fillers	187:193	arg1	use					157:159	the use	153:159	the use of new generation natural fillers, namely, α-cellulose,	153:215	In the current context of green mobility and sustainability, the use of new generation natural fillers, namely, α-cellulose, has gained significant recognition.
33525731	0	31	theme	α-Cellulose	47:57	arg1	Morphology					0:9	Morphology	0:9	Morphology	0:9	Morphology and Physico-Mechanical Threshold of α-Cellulose as Filler in an E-SBR Composite.
33525731	0	31	theme	α-Cellulose	47:57	arg1	Threshold					34:42	Physico-Mechanical Threshold	15:42	Physico-Mechanical Threshold	15:42	Morphology and Physico-Mechanical Threshold of α-Cellulose as Filler in an E-SBR Composite.
33525731	5	32	theme	phr	999:1001	arg1	loading					1003:1009	10 phr loading	996:1009	10 phr loading of α-cellulose	996:1024	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	5	33	theme	Morphological	832:844	arg1	characterization					846:861	Morphological characterization	832:861	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM)	832:955	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	3	34	dep	40	585:586	arg1	to					582:583	to	582:583	to	582:583	In the present work, α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite is prepared by conventional rubber processing method by using variable proportions of α-cellulose (1 to 40 phr) to assess its reinforce ability.
33525731	3	35	theme	styrene	438:444	arg1	composite					471:479	α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite	411:479	α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite	411:479	In the present work, α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite is prepared by conventional rubber processing method by using variable proportions of α-cellulose (1 to 40 phr) to assess its reinforce ability.
33525731	3	36	theme	butadiene	446:454	arg1	composite					471:479	α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite	411:479	α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite	411:479	In the present work, α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite is prepared by conventional rubber processing method by using variable proportions of α-cellulose (1 to 40 phr) to assess its reinforce ability.
33525731	5	37	theme	scanning	879:886	arg1	microscope					897:906	scanning electron microscope	879:906	scanning electron microscope (SEM)	879:912	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	5	37	theme	scanning	879:886	arg1	SEM					909:911	SEM	909:911	SEM	909:911	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	4	38	theme	performance	808:818	arg1	parameters					820:829	performance parameters	808:829	performance parameters	808:829	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	7	39	theme	α-cellulose	1276:1286	arg1	ability					1265:1271	the reinforcement ability	1247:1271	the reinforcement ability of α-cellulose	1247:1286	Characterization of the compound has clearly established the reinforcement ability of α-cellulose.
33525731	3	40	theme	E-SBR	464:468	arg1	composite					471:479	α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite	411:479	α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite	411:479	In the present work, α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite is prepared by conventional rubber processing method by using variable proportions of α-cellulose (1 to 40 phr) to assess its reinforce ability.
33525731	1	41	theme	sustainability	137:150	arg1	context					107:113	the current context	95:113	the current context of green mobility and sustainability	95:150	In the current context of green mobility and sustainability, the use of new generation natural fillers, namely, α-cellulose, has gained significant recognition.
33525731	4	42	theme	physical	639:646	arg1	behavior					686:693	Rheological, physical, visco-elastic and dynamic-mechanical behavior	626:693	Rheological, physical, visco-elastic and dynamic-mechanical behavior	626:693	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	2	43	from	presence	257:264	arg1	α-cellulose					288:298	α-cellulose	288:298	α-cellulose	288:298	The presence of hydroxyl groups on α-cellulose has generated immense eagerness to map its potency as filler in an elastomeric composite.
33525731	2	44	attach	presence	257:264	arg1	α-cellulose					288:298	α-cellulose	288:298	α-cellulose	288:298	The presence of hydroxyl groups on α-cellulose has generated immense eagerness to map its potency as filler in an elastomeric composite.
33525731	2	44	attach	presence	257:264	arg2	groups					278:283	hydroxyl groups	269:283	hydroxyl groups	269:283	The presence of hydroxyl groups on α-cellulose has generated immense eagerness to map its potency as filler in an elastomeric composite.
33525731	4	45	theme	visco-elastic	649:661	arg1	behavior					686:693	Rheological, physical, visco-elastic and dynamic-mechanical behavior	626:693	Rheological, physical, visco-elastic and dynamic-mechanical behavior	626:693	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	1	46	theme	green	118:122	arg1	mobility					124:131	green mobility	118:131	green mobility	118:131	In the current context of green mobility and sustainability, the use of new generation natural fillers, namely, α-cellulose, has gained significant recognition.
33525731	6	47	theme	green	1134:1138	arg1	filler					1140:1145	green filler	1134:1145	green filler (α-cellulose)	1134:1159	With this background, synthetic filler (silica) is substituted by green filler (α-cellulose) in an E-SBR-based composite.
33525731	6	47	theme	green	1134:1138	arg1	α-cellulose					1148:1158	α-cellulose	1148:1158	α-cellulose	1148:1158	With this background, synthetic filler (silica) is substituted by green filler (α-cellulose) in an E-SBR-based composite.
33525731	5	48	theme	morphological	1043:1055	arg1	threshold					1057:1065	the morphological threshold	1039:1065	the morphological threshold	1039:1065	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	4	49	from	dosage	789:794	arg1	terms					799:803	terms	799:803	terms of performance parameters	799:829	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	1	50	theme	mobility	124:131	arg1	context					107:113	the current context	95:113	the current context of green mobility and sustainability	95:150	In the current context of green mobility and sustainability, the use of new generation natural fillers, namely, α-cellulose, has gained significant recognition.
33525731	2	51	theme	immense	314:320	arg1	eagerness					322:330	immense eagerness	314:330	immense eagerness	314:330	The presence of hydroxyl groups on α-cellulose has generated immense eagerness to map its potency as filler in an elastomeric composite.
33525731	7	52	theme	compound	1214:1221	arg1	Characterization					1190:1205	Characterization	1190:1205	Characterization of the compound	1190:1221	Characterization of the compound has clearly established the reinforcement ability of α-cellulose.
33525731	5	53	theme	electron	888:895	arg1	microscope					897:906	scanning electron microscope	879:906	scanning electron microscope (SEM)	879:912	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	5	53	theme	electron	888:895	arg1	SEM					909:911	SEM	909:911	SEM	909:911	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	5	54	theme	10	996:997	arg1	phr					999:1001	phr	999:1001	phr	999:1001	Morphological characterization with the aid of scanning electron microscope (SEM) and transmission electron microscopy (TEM) also substantiated that composite with 10 phr loading of α-cellulose has achieved the morphological threshold.
33525731	3	55	theme	rubber	456:461	arg1	composite					471:479	α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite	411:479	α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite	411:479	In the present work, α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite is prepared by conventional rubber processing method by using variable proportions of α-cellulose (1 to 40 phr) to assess its reinforce ability.
33525731	3	56	theme	conventional	496:507	arg1	method					527:532	conventional rubber processing method	496:532	conventional rubber processing method	496:532	In the present work, α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite is prepared by conventional rubber processing method by using variable proportions of α-cellulose (1 to 40 phr) to assess its reinforce ability.
33525731	4	57	theme	Rheological	626:636	arg1	behavior					686:693	Rheological, physical, visco-elastic and dynamic-mechanical behavior	626:693	Rheological, physical, visco-elastic and dynamic-mechanical behavior	626:693	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	3	58	dep	ability	617:623	arg1	reinforce					607:615	reinforce	607:615	reinforce	607:615	In the present work, α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite is prepared by conventional rubber processing method by using variable proportions of α-cellulose (1 to 40 phr) to assess its reinforce ability.
33525731	4	59	theme	optimized	779:787	arg1	loading					732:738	10 phr loading	725:738	10 phr loading of α-cellulose	725:753	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	4	59	theme	optimized	779:787	arg1	dosage					789:794	an optimized dosage	776:794	an optimized dosage in terms of performance parameters	776:829	Rheological, physical, visco-elastic and dynamic-mechanical behavior have clearly established that 10 phr loading of α-cellulose can be considered as an optimized dosage in terms of performance parameters.
33525731	3	60	theme	rubber	509:514	arg1	method					527:532	conventional rubber processing method	496:532	conventional rubber processing method	496:532	In the present work, α-cellulose-emulsion-grade styrene butadiene rubber (E-SBR) composite is prepared by conventional rubber processing method by using variable proportions of α-cellulose (1 to 40 phr) to assess its reinforce ability.
32354247	1	0	with	women	299:303	arg1	factors					315:321	risk factors	310:321	risk factors associated with placental inflammation	310:360	OBJECTIVE We investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation.
32354247	3	1	theme	risk	606:609	arg1	factors					611:617	maternal risk factors	597:617	maternal risk factors	597:617	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	7	2	from	%	1413:1413	arg1	groups					1456:1461	groups 1	1456:1463	groups 1	1456:1463	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	2	from	%	1413:1413	arg1	2					1466:1466	2	1466:1466	2	1466:1466	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	2	from	%	1413:1413	arg1	3					1473:1473	3	1473:1473	3	1473:1473	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	3	3	theme	risk	793:796	arg1	factors					798:804	immunological risk factors	779:804	immunological risk factors for placental inflammation	779:831	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	1	4	theme	placental	339:347	arg1	inflammation					349:360	placental inflammation	339:360	placental inflammation	339:360	OBJECTIVE We investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation.
32354247	10	5	theme	pathophysiological	2133:2150	arg1	mechanism					2152:2160	the most likely pathophysiological mechanism	2117:2160	the most likely pathophysiological mechanism contributing to various obstetrical complications	2117:2210	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	10	5	theme	pathophysiological	2133:2150	arg1	inflammation					2094:2105	placental inflammation	2084:2105	placental inflammation	2084:2105	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	5	6	from	present	1183:1189	arg1	multigravidas					1219:1231	multigravidas	1219:1231	multigravidas	1219:1231	Live birth rates, composite adverse obstetric outcomes, and the Beksac obstetric index were compared between present and previous pregnancies in multigravidas.
32354247	3	7	dep	Group	672:676	arg1	Patients					852:859	Patients	852:859	Patients with metabolic and immunological risk factors for placental inflammation (n = 53)	852:941	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	3	7	dep	Group	672:676	arg1	Patients					681:688	Patients	681:688	Group 1: Patients with metabolic risk factors for placental inflammation (n = 205)	672:753	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	6	8	theme	Pregnancy	1242:1250	arg1	outcomes					1252:1259	RESULTS Pregnancy outcomes	1234:1259	RESULTS Pregnancy outcomes	1234:1259	RESULTS Pregnancy outcomes were significantly better in the present pregnancy than in previous pregnancies.
32354247	2	9	theme	retrospective	390:402	arg1	study					411:415	This retrospective cohort study	385:415	This retrospective cohort study	385:415	MATERIALS AND METHODS This retrospective cohort study included 300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH to prevent placental inflammation.
32354247	1	10	theme	low-molecular-weight	260:279	arg1	LMWH					290:293	LMWH	290:293	LMWH	290:293	OBJECTIVE We investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation.
32354247	1	10	theme	low-molecular-weight	260:279	arg1	heparin					281:287	low-dose low-molecular-weight heparin	251:287	low-dose low-molecular-weight heparin (LMWH)	251:294	OBJECTIVE We investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation.
32354247	10	11	theme	various	2178:2184	arg1	complications					2198:2210	various obstetrical complications	2178:2210	various obstetrical complications	2178:2210	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	8	12	theme	composite	1655:1663	arg1	outcome					1683:1689	composite adverse pregnancy outcome	1655:1689	composite adverse pregnancy outcome rates	1655:1695	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	5	13	theme	obstetric	1145:1153	arg1	index					1155:1159	the Beksac obstetric index	1134:1159	the Beksac obstetric index	1134:1159	Live birth rates, composite adverse obstetric outcomes, and the Beksac obstetric index were compared between present and previous pregnancies in multigravidas.
32354247	8	14	theme	pregnancy	1673:1681	arg1	outcome					1683:1689	composite adverse pregnancy outcome	1655:1689	composite adverse pregnancy outcome rates	1655:1695	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	10	15	theme	Low-dose	1967:1974	arg1	prophylaxis					2005:2015	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis	1956:2015	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis	1956:2015	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	5	16	theme	obstetric	1110:1118	arg1	outcomes					1120:1127	composite adverse obstetric outcomes	1092:1127	composite adverse obstetric outcomes	1092:1127	Live birth rates, composite adverse obstetric outcomes, and the Beksac obstetric index were compared between present and previous pregnancies in multigravidas.
32354247	3	17	theme	placental	911:919	arg1	n = 53					935:940	n = 53	935:940	n = 53	935:940	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	3	17	theme	placental	911:919	arg1	inflammation					921:932	placental inflammation	911:932	placental inflammation (n = 53)	911:941	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	10	18	theme	immunological	2052:2064	arg1	disorders					2066:2074	metabolic and immunological disorders	2038:2074	metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications	2038:2210	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	4	19	theme	demographic	965:975	arg1	features					977:984	demographic features	965:984	demographic features	965:984	Obstetric histories, demographic features, clinical characteristics, and present pregnancy outcomes were compared between groups.
32354247	3	20	theme	risk	705:708	arg1	factors					710:716	metabolic risk factors	695:716	metabolic risk factors for placental inflammation	695:743	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	8	21	from	%	1753:1753	arg1	groups					1794:1799	groups 1, 2, and 3	1794:1811	groups 1, 2, and 3	1794:1811	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	3	22	with	Patients	852:859	arg1	factors					899:905	metabolic and immunological risk factors	866:905	metabolic and immunological risk factors for placental inflammation (n = 53)	866:941	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	7	23	from	%	1451:1451	arg1	groups					1456:1461	groups 1	1456:1463	groups 1	1456:1463	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	23	from	%	1451:1451	arg1	2					1466:1466	2	1466:1466	2	1466:1466	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	23	from	%	1451:1451	arg1	3					1473:1473	3	1473:1473	3	1473:1473	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	10	24	theme	heparin	1997:2003	arg1	prophylaxis					2005:2015	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis	1956:2015	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis	1956:2015	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	3	25	theme	immunological	880:892	arg1	factors					899:905	metabolic and immunological risk factors	866:905	metabolic and immunological risk factors for placental inflammation (n = 53)	866:941	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	0	26	theme	metabolic	104:112	arg1	inflammation					162:173	metabolic and immunological disorder-associated placental inflammation	104:173	metabolic and immunological disorder-associated placental inflammation	104:173	Low-dose low-molecular-weight heparin prophylaxis against obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation.
32354247	1	27	theme	prophylactic	220:231	arg1	administration					233:246	prophylactic administration	220:246	prophylactic administration of low-dose low-molecular-weight heparin (LMWH)	220:294	OBJECTIVE We investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation.
32354247	10	28	theme	metabolic	2038:2046	arg1	disorders					2066:2074	metabolic and immunological disorders	2038:2074	metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications	2038:2210	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	3	29	theme	metabolic	866:874	arg1	factors					899:905	metabolic and immunological risk factors	866:905	metabolic and immunological risk factors for placental inflammation (n = 53)	866:941	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	0	30	theme	immunological	118:130	arg1	inflammation					162:173	metabolic and immunological disorder-associated placental inflammation	104:173	metabolic and immunological disorder-associated placental inflammation	104:173	Low-dose low-molecular-weight heparin prophylaxis against obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation.
32354247	4	31	theme	pregnancy	1025:1033	arg1	outcomes					1035:1042	present pregnancy outcomes	1017:1042	present pregnancy outcomes	1017:1042	Obstetric histories, demographic features, clinical characteristics, and present pregnancy outcomes were compared between groups.
32354247	0	32	from	complications	70:82	arg1	pregnancies					87:97	pregnancies	87:97	pregnancies with metabolic and immunological disorder-associated placental inflammation	87:173	Low-dose low-molecular-weight heparin prophylaxis against obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation.
32354247	0	33	theme	placental	152:160	arg1	inflammation					162:173	metabolic and immunological disorder-associated placental inflammation	104:173	metabolic and immunological disorder-associated placental inflammation	104:173	Low-dose low-molecular-weight heparin prophylaxis against obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation.
32354247	7	34	located	observed	1369:1376	arg2	increase					1356:1363	A significant increase	1342:1363	A significant increase	1342:1363	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	34	located	observed	1369:1376	arg1	rates					1392:1396	live birth rates	1381:1396	live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively)	1381:1488	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	35	from	%	1420:1420	arg1	groups					1456:1461	groups 1	1456:1463	groups 1	1456:1463	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	35	from	%	1420:1420	arg1	2					1466:1466	2	1466:1466	2	1466:1466	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	35	from	%	1420:1420	arg1	3					1473:1473	3	1473:1473	3	1473:1473	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	2	36	theme	low-dose	539:546	arg1	LMWH					548:551	prophylactic low-dose LMWH	526:551	prophylactic low-dose LMWH	526:551	MATERIALS AND METHODS This retrospective cohort study included 300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH to prevent placental inflammation.
32354247	0	37	theme	Low-dose	0:7	arg1	heparin					30:36	Low-dose low-molecular-weight heparin	0:36	Low-dose low-molecular-weight heparin	0:36	Low-dose low-molecular-weight heparin prophylaxis against obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation.
32354247	3	38	dep	Group	756:760	arg1	Patients					765:772	Patients	765:772	Group 2: Patients with immunological risk factors for placental inflammation (n = 42)	756:840	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	9	39	theme	birth	1853:1857	arg1	rates					1899:1903	Live birth and composite adverse obstetric outcome rates	1848:1903	Live birth and composite adverse obstetric outcome rates	1848:1903	Live birth and composite adverse obstetric outcome rates were 70% and 33.3%, respectively in primigravidas.
32354247	2	40	theme	placental	564:572	arg1	inflammation					574:585	placental inflammation	564:585	placental inflammation	564:585	MATERIALS AND METHODS This retrospective cohort study included 300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH to prevent placental inflammation.
32354247	9	41	theme	composite	1863:1871	arg1	outcome					1891:1897	composite adverse obstetric outcome	1863:1897	composite adverse obstetric outcome	1863:1897	Live birth and composite adverse obstetric outcome rates were 70% and 33.3%, respectively in primigravidas.
32354247	9	42	from	%	1922:1922	arg1	primigravidas					1941:1953	primigravidas	1941:1953	primigravidas	1941:1953	Live birth and composite adverse obstetric outcome rates were 70% and 33.3%, respectively in primigravidas.
32354247	7	43	theme	obstetric	1508:1516	arg1	index					1518:1522	the Beksac obstetric index	1497:1522	the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all)	1497:1626	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	9	44	theme	obstetric	1881:1889	arg1	outcome					1891:1897	composite adverse obstetric outcome	1863:1897	composite adverse obstetric outcome	1863:1897	Live birth and composite adverse obstetric outcome rates were 70% and 33.3%, respectively in primigravidas.
32354247	2	45	theme	pregnant	430:437	arg1	women					439:443	300 pregnant women	426:443	300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH	426:551	MATERIALS AND METHODS This retrospective cohort study included 300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH to prevent placental inflammation.
32354247	5	46	theme	adverse	1102:1108	arg1	outcomes					1120:1127	composite adverse obstetric outcomes	1092:1127	composite adverse obstetric outcomes	1092:1127	Live birth rates, composite adverse obstetric outcomes, and the Beksac obstetric index were compared between present and previous pregnancies in multigravidas.
32354247	7	47	theme	live	1381:1384	arg1	rates					1392:1396	live birth rates	1381:1396	live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively)	1381:1488	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	48	dep	rates	1392:1396	arg1	%					1403:1403	33.4%	1399:1403	33.4%	1399:1403	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	48	dep	rates	1392:1396	arg1	%					1413:1413	69.9%	1409:1413	69.9%	1409:1413	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	8	49	from	decrease	1643:1650	arg1	rates					1691:1695	composite adverse pregnancy outcome rates	1655:1695	composite adverse pregnancy outcome rates	1655:1695	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	2	50	theme	singleton	452:460	arg1	pregnancy					462:470	a singleton pregnancy	450:470	a singleton pregnancy (30 primigravidas and 270 multigravidas)	450:511	MATERIALS AND METHODS This retrospective cohort study included 300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH to prevent placental inflammation.
32354247	5	51	theme	birth	1079:1083	arg1	rates					1085:1089	Live birth rates	1074:1089	Live birth rates	1074:1089	Live birth rates, composite adverse obstetric outcomes, and the Beksac obstetric index were compared between present and previous pregnancies in multigravidas.
32354247	3	52	theme	maternal	597:604	arg1	factors					611:617	maternal risk factors	597:617	maternal risk factors	597:617	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	5	53	from	multigravidas	1219:1231	arg1	present					1183:1189	present	1183:1189	present	1183:1189	Live birth rates, composite adverse obstetric outcomes, and the Beksac obstetric index were compared between present and previous pregnancies in multigravidas.
32354247	3	54	with	Patients	765:772	arg1	factors					798:804	immunological risk factors	779:804	immunological risk factors for placental inflammation	779:831	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	8	55	from	%	1789:1789	arg1	groups					1794:1799	groups 1, 2, and 3	1794:1811	groups 1, 2, and 3	1794:1811	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	0	56	with	pregnancies	87:97	arg1	inflammation					162:173	metabolic and immunological disorder-associated placental inflammation	104:173	metabolic and immunological disorder-associated placental inflammation	104:173	Low-dose low-molecular-weight heparin prophylaxis against obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation.
32354247	1	57	theme	administration	233:246	arg1	importance					206:215	the importance	202:215	the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation	202:360	OBJECTIVE We investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation.
32354247	7	58	from	0.32	1525:1528	arg1	groups					1576:1581	groups 1, 2, and 3	1576:1593	groups 1, 2, and 3	1576:1593	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	10	59	theme	likely	2126:2131	arg1	mechanism					2152:2160	the most likely pathophysiological mechanism	2117:2160	the most likely pathophysiological mechanism contributing to various obstetrical complications	2117:2210	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	10	59	theme	likely	2126:2131	arg1	inflammation					2094:2105	placental inflammation	2084:2105	placental inflammation	2084:2105	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	3	60	theme	immunological	779:791	arg1	factors					798:804	immunological risk factors	779:804	immunological risk factors for placental inflammation	779:831	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	2	61	theme	cohort	404:409	arg1	study					411:415	This retrospective cohort study	385:415	This retrospective cohort study	385:415	MATERIALS AND METHODS This retrospective cohort study included 300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH to prevent placental inflammation.
32354247	1	62	theme	low-dose	251:258	arg1	LMWH					290:293	LMWH	290:293	LMWH	290:293	OBJECTIVE We investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation.
32354247	1	62	theme	low-dose	251:258	arg1	heparin					281:287	low-dose low-molecular-weight heparin	251:287	low-dose low-molecular-weight heparin (LMWH)	251:294	OBJECTIVE We investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation.
32354247	6	63	theme	RESULTS	1234:1240	arg1	outcomes					1252:1259	RESULTS Pregnancy outcomes	1234:1259	RESULTS Pregnancy outcomes	1234:1259	RESULTS Pregnancy outcomes were significantly better in the present pregnancy than in previous pregnancies.
32354247	8	64	theme	significant	1631:1641	arg1	decrease					1643:1650	A significant decrease	1629:1650	A significant decrease in composite adverse pregnancy outcome rates	1629:1695	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	1	65	theme	heparin	281:287	arg1	administration					233:246	prophylactic administration	220:246	prophylactic administration of low-dose low-molecular-weight heparin (LMWH)	220:294	OBJECTIVE We investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation.
32354247	3	66	dep	follows	663:669	arg1	n = 205					746:752	n = 205	746:752	n = 205	746:752	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	3	66	dep	follows	663:669	arg1	Group					756:760	Group 2	756:762	Group 2: Patients with immunological risk factors for placental inflammation (n = 42)	756:840	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	3	66	dep	follows	663:669	arg1	Group					672:676	Group 1	672:678	Group 1: Patients with metabolic risk factors for placental inflammation (n = 205)	672:753	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	3	66	dep	follows	663:669	arg1	Group					843:847	Group 3	843:849	Group 3	843:849	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	8	67	dep	pregnancy	1729:1737	arg1	p < .001					1829:1836	p < .001	1829:1836	p < .001	1829:1836	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	3	68	theme	placental	810:818	arg1	inflammation					820:831	placental inflammation	810:831	placental inflammation	810:831	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	5	69	theme	Beksac	1138:1143	arg1	index					1155:1159	the Beksac obstetric index	1134:1159	the Beksac obstetric index	1134:1159	Live birth rates, composite adverse obstetric outcomes, and the Beksac obstetric index were compared between present and previous pregnancies in multigravidas.
32354247	4	70	theme	clinical	987:994	arg1	characteristics					996:1010	clinical characteristics	987:1010	clinical characteristics	987:1010	Obstetric histories, demographic features, clinical characteristics, and present pregnancy outcomes were compared between groups.
32354247	6	71	theme	previous	1320:1327	arg1	pregnancies					1329:1339	previous pregnancies	1320:1339	previous pregnancies	1320:1339	RESULTS Pregnancy outcomes were significantly better in the present pregnancy than in previous pregnancies.
32354247	10	72	theme	low-molecular-weight	1976:1995	arg1	prophylaxis					2005:2015	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis	1956:2015	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis	1956:2015	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	8	73	theme	adverse	1665:1671	arg1	outcome					1683:1689	composite adverse pregnancy outcome	1655:1689	composite adverse pregnancy outcome rates	1655:1695	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	4	74	theme	Obstetric	944:952	arg1	histories					954:962	Obstetric histories	944:962	Obstetric histories	944:962	Obstetric histories, demographic features, clinical characteristics, and present pregnancy outcomes were compared between groups.
32354247	2	75	with	women	439:443	arg1	pregnancy					462:470	a singleton pregnancy	450:470	a singleton pregnancy (30 primigravidas and 270 multigravidas)	450:511	MATERIALS AND METHODS This retrospective cohort study included 300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH to prevent placental inflammation.
32354247	10	76	theme	CONCLUSION	1956:1965	arg1	prophylaxis					2005:2015	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis	1956:2015	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis	1956:2015	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	3	77	theme	metabolic	695:703	arg1	factors					710:716	metabolic risk factors	695:716	metabolic risk factors for placental inflammation	695:743	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	8	78	theme	outcome	1683:1689	arg1	rates					1691:1695	composite adverse pregnancy outcome rates	1655:1695	composite adverse pregnancy outcome rates	1655:1695	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	7	79	from	%	1441:1441	arg1	groups					1456:1461	groups 1	1456:1463	groups 1	1456:1463	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	79	from	%	1441:1441	arg1	2					1466:1466	2	1466:1466	2	1466:1466	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	79	from	%	1441:1441	arg1	3					1473:1473	3	1473:1473	3	1473:1473	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	10	80	theme	obstetrical	2186:2196	arg1	complications					2198:2210	various obstetrical complications	2178:2210	various obstetrical complications	2178:2210	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	6	81	theme	present	1294:1300	arg1	pregnancy					1302:1310	the present pregnancy	1290:1310	the present pregnancy	1290:1310	RESULTS Pregnancy outcomes were significantly better in the present pregnancy than in previous pregnancies.
32354247	3	82	with	Patients	681:688	arg1	factors					710:716	metabolic risk factors	695:716	metabolic risk factors for placental inflammation	695:743	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	5	83	theme	previous	1195:1202	arg1	pregnancies					1204:1214	previous pregnancies	1195:1214	previous pregnancies	1195:1214	Live birth rates, composite adverse obstetric outcomes, and the Beksac obstetric index were compared between present and previous pregnancies in multigravidas.
32354247	2	84	dep	MATERIALS	363:371	arg1	included					417:424	included	417:424	included 300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH	417:551	MATERIALS AND METHODS This retrospective cohort study included 300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH to prevent placental inflammation.
32354247	3	85	theme	risk	894:897	arg1	factors					899:905	metabolic and immunological risk factors	866:905	metabolic and immunological risk factors for placental inflammation (n = 53)	866:941	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	0	86	theme	disorder-associated	132:150	arg1	inflammation					162:173	metabolic and immunological disorder-associated placental inflammation	104:173	metabolic and immunological disorder-associated placental inflammation	104:173	Low-dose low-molecular-weight heparin prophylaxis against obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation.
32354247	8	87	theme	present	1721:1727	arg1	%					1760:1760	28.9% vs. 100%	1756:1769	%	1760:1760	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	8	87	theme	present	1721:1727	arg1	%					1780:1780	24.5%	1776:1780	24.5%	1776:1780	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	8	87	theme	present	1721:1727	arg1	100					1750:1752	100	1750:1752	100	1750:1752	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	8	87	theme	present	1721:1727	arg1	pregnancy					1729:1737	the present pregnancy	1717:1737	the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all)	1717:1845	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	8	87	theme	present	1721:1727	arg1	%					1753:1753	23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively	1740:1825	%	1753:1753	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	1	88	from	importance	206:215	arg1	women					299:303	women	299:303	women with risk factors associated with placental inflammation	299:360	OBJECTIVE We investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation.
32354247	4	89	theme	present	1017:1023	arg1	outcomes					1035:1042	present pregnancy outcomes	1017:1042	present pregnancy outcomes	1017:1042	Obstetric histories, demographic features, clinical characteristics, and present pregnancy outcomes were compared between groups.
32354247	10	90	theme	placental	2084:2092	arg1	inflammation					2094:2105	placental inflammation	2084:2105	placental inflammation	2084:2105	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	10	90	theme	placental	2084:2092	arg1	mechanism					2152:2160	the most likely pathophysiological mechanism	2117:2160	the most likely pathophysiological mechanism contributing to various obstetrical complications	2117:2210	CONCLUSION Low-dose low-molecular-weight heparin prophylaxis is useful to prevent metabolic and immunological disorders causing placental inflammation, which is the most likely pathophysiological mechanism contributing to various obstetrical complications.
32354247	1	91	dep	OBJECTIVE	176:184	arg1	investigated					189:200	investigated	189:200	investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation	189:360	OBJECTIVE We investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation.
32354247	0	92	theme	low-molecular-weight	9:28	arg1	heparin					30:36	Low-dose low-molecular-weight heparin	0:36	Low-dose low-molecular-weight heparin	0:36	Low-dose low-molecular-weight heparin prophylaxis against obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation.
32354247	8	93	theme	%	1744:1744	arg1	pregnancy					1729:1737	the present pregnancy	1717:1737	the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all)	1717:1845	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	8	93	theme	%	1744:1744	arg1	%					1753:1753	23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively	1740:1825	%	1753:1753	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	2	94	theme	prophylactic	526:537	arg1	LMWH					548:551	prophylactic low-dose LMWH	526:551	prophylactic low-dose LMWH	526:551	MATERIALS AND METHODS This retrospective cohort study included 300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH to prevent placental inflammation.
32354247	9	95	theme	Live	1848:1851	arg1	birth					1853:1857	Live birth	1848:1857	Live birth	1848:1857	Live birth and composite adverse obstetric outcome rates were 70% and 33.3%, respectively in primigravidas.
32354247	7	96	from	%	1430:1430	arg1	groups					1456:1461	groups 1	1456:1463	groups 1	1456:1463	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	96	from	%	1430:1430	arg1	2					1466:1466	2	1466:1466	2	1466:1466	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	96	from	%	1430:1430	arg1	3					1473:1473	3	1473:1473	3	1473:1473	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	3	97	theme	placental	722:730	arg1	inflammation					732:743	placental inflammation	722:743	placental inflammation	722:743	Based on maternal risk factors, patients were categorized into 3 groups as follows: Group 1: Patients with metabolic risk factors for placental inflammation (n = 205), Group 2: Patients with immunological risk factors for placental inflammation (n = 42), Group 3: Patients with metabolic and immunological risk factors for placental inflammation (n = 53).
32354247	0	98	theme	obstetrical	58:68	arg1	complications					70:82	obstetrical complications	58:82	obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation	58:173	Low-dose low-molecular-weight heparin prophylaxis against obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation.
32354247	7	99	theme	birth	1386:1390	arg1	rates					1392:1396	live birth rates	1381:1396	live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively)	1381:1488	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	9	100	theme	adverse	1873:1879	arg1	outcome					1891:1897	composite adverse obstetric outcome	1863:1897	composite adverse obstetric outcome	1863:1897	Live birth and composite adverse obstetric outcome rates were 70% and 33.3%, respectively in primigravidas.
32354247	9	101	from	%	1912:1912	arg1	primigravidas					1941:1953	primigravidas	1941:1953	primigravidas	1941:1953	Live birth and composite adverse obstetric outcome rates were 70% and 33.3%, respectively in primigravidas.
32354247	5	102	theme	composite	1092:1100	arg1	outcomes					1120:1127	composite adverse obstetric outcomes	1092:1127	composite adverse obstetric outcomes	1092:1127	Live birth rates, composite adverse obstetric outcomes, and the Beksac obstetric index were compared between present and previous pregnancies in multigravidas.
32354247	9	103	theme	outcome	1891:1897	arg1	rates					1899:1903	Live birth and composite adverse obstetric outcome rates	1848:1903	Live birth and composite adverse obstetric outcome rates	1848:1903	Live birth and composite adverse obstetric outcome rates were 70% and 33.3%, respectively in primigravidas.
32354247	7	104	theme	Beksac	1501:1506	arg1	index					1518:1522	the Beksac obstetric index	1497:1522	the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all)	1497:1626	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	2	105	dep	pregnancy	462:470	arg1	primigravidas					476:488	30 primigravidas and 270 multigravidas	473:510	primigravidas	476:488	MATERIALS AND METHODS This retrospective cohort study included 300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH to prevent placental inflammation.
32354247	2	105	dep	pregnancy	462:470	arg1	multigravidas					498:510	30 primigravidas and 270 multigravidas	473:510	multigravidas	498:510	MATERIALS AND METHODS This retrospective cohort study included 300 pregnant women with a singleton pregnancy (30 primigravidas and 270 multigravidas) who received prophylactic low-dose LMWH to prevent placental inflammation.
32354247	7	106	dep	index	1518:1522	arg1	0.33					1540:1543	0.33	1540:1543	0.33	1540:1543	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	106	dep	index	1518:1522	arg1	p < .001					1610:1617	p < .001	1610:1617	the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all)	1497:1626	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	7	106	dep	index	1518:1522	arg1	0.32					1525:1528	0.32	1525:1528	0.32	1525:1528	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	5	107	theme	Live	1074:1077	arg1	rates					1085:1089	Live birth rates	1074:1089	Live birth rates	1074:1089	Live birth rates, composite adverse obstetric outcomes, and the Beksac obstetric index were compared between present and previous pregnancies in multigravidas.
32354247	7	108	theme	significant	1344:1354	arg1	increase					1356:1363	A significant increase	1342:1363	A significant increase	1342:1363	A significant increase was observed in live birth rates (33.4% vs. 69.9%, 27.5% vs. 60.5%, and 30.1% vs. 69.4% in groups 1, 2, and 3, respectively) and in the Beksac obstetric index (0.32 vs. 0.43, 0.33 vs. 0.47, and 0.38 vs. 0.57 in groups 1, 2, and 3 respectively) (p < .001 for all).
32354247	8	109	from	%	1780:1780	arg1	groups					1794:1799	groups 1, 2, and 3	1794:1811	groups 1, 2, and 3	1794:1811	A significant decrease in composite adverse pregnancy outcome rates was observed during the present pregnancy (23.5% vs. 100%, 28.9% vs. 100%, and 24.5% vs. 100% in groups 1, 2, and 3, respectively) (p < .001 for all).
32354247	1	110	theme	risk	310:313	arg1	factors					315:321	risk factors	310:321	risk factors associated with placental inflammation	310:360	OBJECTIVE We investigated the importance of prophylactic administration of low-dose low-molecular-weight heparin (LMWH) in women with risk factors associated with placental inflammation.
34167007	6	0	theme	detection	942:950	arg1	1.81 µmol L-1					956:968	1.81 µmol L-1	956:968	1.81 µmol L-1	956:968	The limit of detection was 1.81 µmol L-1.
34167007	6	0	theme	detection	942:950	arg1	limit					933:937	The limit	929:937	The limit of detection	929:950	The limit of detection was 1.81 µmol L-1.
34167007	1	1	theme	macroporous	370:380	arg1	layer					382:386	a macroporous layer	368:386	a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry)	368:450	A histamine biosensor was developed based on a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry).
34167007	5	2	dep	ranges	875:880	arg1	125.0-400.0 µmol L-1					907:926	125.0-400.0 µmol L-1	907:926	125.0-400.0 µmol L-1	907:926	The proposed biosensor displayed two linear ranges: 2.50-125.0 µmol L-1 and 125.0-400.0 µmol L-1.
34167007	5	2	dep	ranges	875:880	arg1	2.50-125.0 µmol L-1					883:901	2.50-125.0 µmol L-1	883:901	2.50-125.0 µmol L-1	883:901	The proposed biosensor displayed two linear ranges: 2.50-125.0 µmol L-1 and 125.0-400.0 µmol L-1.
34167007	5	2	dep	ranges	875:880	arg1	ranges					875:880	two linear ranges	864:880	two linear ranges: 2.50-125.0 µmol L-1 and 125.0-400.0 µmol L-1	864:926	The proposed biosensor displayed two linear ranges: 2.50-125.0 µmol L-1 and 125.0-400.0 µmol L-1.
34167007	4	3	theme	reduction	720:728	arg1	current					730:736	The PB reduction current	713:736	The PB reduction current	713:736	The PB reduction current was measured during the hydrogen peroxide-releasing oxidation of histamine catalyzed by DAO.
34167007	2	4	theme	diamine	564:570	arg1	DAO					581:583	DAO	581:583	DAO	581:583	With its high specific surface area and conductivity, CS-AuNPs Cry proved an excellent supporting material for diamine oxidase (DAO) immobilization.
34167007	2	4	theme	diamine	564:570	arg1	oxidase					572:578	diamine oxidase	564:578	diamine oxidase (DAO) immobilization	564:599	With its high specific surface area and conductivity, CS-AuNPs Cry proved an excellent supporting material for diamine oxidase (DAO) immobilization.
34167007	8	5	theme	histamine	1117:1125	arg1	levels					1127:1132	histamine levels	1117:1132	histamine levels in fish and shrimps with satisfactory recoveries	1117:1181	The biosensor determined histamine levels in fish and shrimps with satisfactory recoveries, and the obtained results agreed with those obtained by ELISA.
34167007	7	6	dep	good	991:994	arg1	%					1007:1007	RSD = 5.46%	997:1007	RSD = 5.46%	997:1007	Reproducibility was good (RSD = 5.46%), operational stability high, long-term stability excellent, and selectivity good.
34167007	4	7	theme	histamine	803:811	arg1	oxidation					790:798	the hydrogen peroxide-releasing oxidation	758:798	the hydrogen peroxide-releasing oxidation of histamine catalyzed by DAO	758:828	The PB reduction current was measured during the hydrogen peroxide-releasing oxidation of histamine catalyzed by DAO.
34167007	0	8	theme	composite	120:128	arg1	cryogel					130:136	composite cryogel	120:136	composite cryogel on Prussian blue-coated multi-walled carbon nanotubes	120:190	An enzymatic histamine biosensor based on a screen-printed carbon electrode modified with a chitosan-gold nanoparticles composite cryogel on Prussian blue-coated multi-walled carbon nanotubes.
34167007	1	9	theme	chitosan-gold	391:403	arg1	nanoparticles					405:417	chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry)	391:450	chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry)	391:450	A histamine biosensor was developed based on a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry).
34167007	2	10	theme	supporting	540:549	arg1	material					551:558	an excellent supporting material	527:558	an excellent supporting material for diamine oxidase (DAO) immobilization	527:599	With its high specific surface area and conductivity, CS-AuNPs Cry proved an excellent supporting material for diamine oxidase (DAO) immobilization.
34167007	1	11	theme	nanoparticles	405:417	arg1	layer					382:386	a macroporous layer	368:386	a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry)	368:450	A histamine biosensor was developed based on a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry).
34167007	1	12	theme	histamine	195:203	arg1	biosensor					205:213	A histamine biosensor	193:213	A histamine biosensor	193:213	A histamine biosensor was developed based on a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry).
34167007	0	13	theme	enzymatic	3:11	arg1	biosensor					23:31	An enzymatic histamine biosensor	0:31	An enzymatic histamine biosensor based on a screen-printed carbon electrode modified with a chitosan-gold	0:104	An enzymatic histamine biosensor based on a screen-printed carbon electrode modified with a chitosan-gold nanoparticles composite cryogel on Prussian blue-coated multi-walled carbon nanotubes.
34167007	1	14	theme	composite	419:427	arg1	cryogel					429:435	composite cryogel	419:435	chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry)	391:450	A histamine biosensor was developed based on a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry).
34167007	1	14	theme	composite	419:427	arg1	Cry					447:449	Cry	447:449	Cry	447:449	A histamine biosensor was developed based on a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry).
34167007	4	15	theme	peroxide-releasing	771:788	arg1	oxidation					790:798	the hydrogen peroxide-releasing oxidation	758:798	the hydrogen peroxide-releasing oxidation of histamine catalyzed by DAO	758:828	The PB reduction current was measured during the hydrogen peroxide-releasing oxidation of histamine catalyzed by DAO.
34167007	2	16	theme	surface	476:482	arg1	area					484:487	its high specific surface area	458:487	its high specific surface area	458:487	With its high specific surface area and conductivity, CS-AuNPs Cry proved an excellent supporting material for diamine oxidase (DAO) immobilization.
34167007	4	17	theme	hydrogen	762:769	arg1	oxidation					790:798	the hydrogen peroxide-releasing oxidation	758:798	the hydrogen peroxide-releasing oxidation of histamine catalyzed by DAO	758:828	The PB reduction current was measured during the hydrogen peroxide-releasing oxidation of histamine catalyzed by DAO.
34167007	2	18	theme	specific	467:474	arg1	area					484:487	its high specific surface area	458:487	its high specific surface area	458:487	With its high specific surface area and conductivity, CS-AuNPs Cry proved an excellent supporting material for diamine oxidase (DAO) immobilization.
34167007	5	19	theme	proposed	835:842	arg1	biosensor					844:852	The proposed biosensor	831:852	The proposed biosensor	831:852	The proposed biosensor displayed two linear ranges: 2.50-125.0 µmol L-1 and 125.0-400.0 µmol L-1.
34167007	8	20	with	fish	1137:1140	arg1	recoveries					1172:1181	satisfactory recoveries	1159:1181	satisfactory recoveries	1159:1181	The biosensor determined histamine levels in fish and shrimps with satisfactory recoveries, and the obtained results agreed with those obtained by ELISA.
34167007	0	21	theme	histamine	13:21	arg1	biosensor					23:31	An enzymatic histamine biosensor	0:31	An enzymatic histamine biosensor based on a screen-printed carbon electrode modified with a chitosan-gold	0:104	An enzymatic histamine biosensor based on a screen-printed carbon electrode modified with a chitosan-gold nanoparticles composite cryogel on Prussian blue-coated multi-walled carbon nanotubes.
34167007	2	22	theme	CS-AuNPs	507:514	arg1	Cry					516:518	CS-AuNPs Cry	507:518	CS-AuNPs Cry	507:518	With its high specific surface area and conductivity, CS-AuNPs Cry proved an excellent supporting material for diamine oxidase (DAO) immobilization.
34167007	0	23	theme	blue-coated	150:160	arg1	nanotubes					182:190	Prussian blue-coated multi-walled carbon nanotubes	141:190	Prussian blue-coated multi-walled carbon nanotubes	141:190	An enzymatic histamine biosensor based on a screen-printed carbon electrode modified with a chitosan-gold nanoparticles composite cryogel on Prussian blue-coated multi-walled carbon nanotubes.
34167007	3	24	theme	redox	616:620	arg1	mediator					622:629	a redox mediator	614:629	a redox mediator	614:629	PB acted as a redox mediator to promote electron transfer between hydrogen peroxide and the electrode surface.
34167007	3	24	theme	redox	616:620	arg1	PB					602:603	PB	602:603	PB	602:603	PB acted as a redox mediator to promote electron transfer between hydrogen peroxide and the electrode surface.
34167007	1	25	dep	nanoparticles	405:417	arg1	cryogel					429:435	composite cryogel	419:435	chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry)	391:450	A histamine biosensor was developed based on a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry).
34167007	1	25	dep	nanoparticles	405:417	arg1	Cry					447:449	Cry	447:449	Cry	447:449	A histamine biosensor was developed based on a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry).
34167007	0	26	theme	Prussian	141:148	arg1	nanotubes					182:190	Prussian blue-coated multi-walled carbon nanotubes	141:190	Prussian blue-coated multi-walled carbon nanotubes	141:190	An enzymatic histamine biosensor based on a screen-printed carbon electrode modified with a chitosan-gold nanoparticles composite cryogel on Prussian blue-coated multi-walled carbon nanotubes.
34167007	5	27	theme	linear	868:873	arg1	125.0-400.0 µmol L-1					907:926	125.0-400.0 µmol L-1	907:926	125.0-400.0 µmol L-1	907:926	The proposed biosensor displayed two linear ranges: 2.50-125.0 µmol L-1 and 125.0-400.0 µmol L-1.
34167007	5	27	theme	linear	868:873	arg1	2.50-125.0 µmol L-1					883:901	2.50-125.0 µmol L-1	883:901	2.50-125.0 µmol L-1	883:901	The proposed biosensor displayed two linear ranges: 2.50-125.0 µmol L-1 and 125.0-400.0 µmol L-1.
34167007	5	27	theme	linear	868:873	arg1	ranges					875:880	two linear ranges	864:880	two linear ranges: 2.50-125.0 µmol L-1 and 125.0-400.0 µmol L-1	864:926	The proposed biosensor displayed two linear ranges: 2.50-125.0 µmol L-1 and 125.0-400.0 µmol L-1.
34167007	0	28	theme	screen-printed	44:57	arg1	electrode					66:74	a screen-printed carbon electrode	42:74	a screen-printed carbon electrode modified with a chitosan-gold	42:104	An enzymatic histamine biosensor based on a screen-printed carbon electrode modified with a chitosan-gold nanoparticles composite cryogel on Prussian blue-coated multi-walled carbon nanotubes.
34167007	1	29	theme	multi-walled	325:336	arg1	nanotubes					345:353	multi-walled carbon nanotubes	325:353	multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry)	325:450	A histamine biosensor was developed based on a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry).
34167007	0	30	theme	carbon	175:180	arg1	nanotubes					182:190	Prussian blue-coated multi-walled carbon nanotubes	141:190	Prussian blue-coated multi-walled carbon nanotubes	141:190	An enzymatic histamine biosensor based on a screen-printed carbon electrode modified with a chitosan-gold nanoparticles composite cryogel on Prussian blue-coated multi-walled carbon nanotubes.
34167007	3	31	theme	hydrogen	668:675	arg1	peroxide					677:684	hydrogen peroxide	668:684	hydrogen peroxide	668:684	PB acted as a redox mediator to promote electron transfer between hydrogen peroxide and the electrode surface.
34167007	2	32	theme	oxidase	572:578	arg1	immobilization					586:599	diamine oxidase (DAO) immobilization	564:599	diamine oxidase (DAO) immobilization	564:599	With its high specific surface area and conductivity, CS-AuNPs Cry proved an excellent supporting material for diamine oxidase (DAO) immobilization.
34167007	0	33	theme	multi-walled	162:173	arg1	nanotubes					182:190	Prussian blue-coated multi-walled carbon nanotubes	141:190	Prussian blue-coated multi-walled carbon nanotubes	141:190	An enzymatic histamine biosensor based on a screen-printed carbon electrode modified with a chitosan-gold nanoparticles composite cryogel on Prussian blue-coated multi-walled carbon nanotubes.
34167007	8	34	from	levels	1127:1132	arg1	shrimps					1146:1152	shrimps	1146:1152	shrimps	1146:1152	The biosensor determined histamine levels in fish and shrimps with satisfactory recoveries, and the obtained results agreed with those obtained by ELISA.
34167007	8	34	from	levels	1127:1132	arg1	fish					1137:1140	fish	1137:1140	fish	1137:1140	The biosensor determined histamine levels in fish and shrimps with satisfactory recoveries, and the obtained results agreed with those obtained by ELISA.
34167007	8	35	theme	obtained	1192:1199	arg1	results					1201:1207	the obtained results	1188:1207	the obtained results	1188:1207	The biosensor determined histamine levels in fish and shrimps with satisfactory recoveries, and the obtained results agreed with those obtained by ELISA.
34167007	3	36	theme	electron	642:649	arg1	transfer					651:658	electron transfer	642:658	electron transfer between hydrogen peroxide and the electrode surface	642:710	PB acted as a redox mediator to promote electron transfer between hydrogen peroxide and the electrode surface.
34167007	1	37	theme	screen-printed	240:253	arg1	electrode					262:270	a screen-printed carbon electrode	238:270	a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry)	238:450	A histamine biosensor was developed based on a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry).
34167007	1	38	theme	carbon	255:260	arg1	electrode					262:270	a screen-printed carbon electrode	238:270	a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry)	238:450	A histamine biosensor was developed based on a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry).
34167007	2	39	theme	excellent	530:538	arg1	material					551:558	an excellent supporting material	527:558	an excellent supporting material for diamine oxidase (DAO) immobilization	527:599	With its high specific surface area and conductivity, CS-AuNPs Cry proved an excellent supporting material for diamine oxidase (DAO) immobilization.
34167007	3	40	theme	electrode	694:702	arg1	surface					704:710	the electrode surface	690:710	the electrode surface	690:710	PB acted as a redox mediator to promote electron transfer between hydrogen peroxide and the electrode surface.
34167007	2	41	theme	high	462:465	arg1	area					484:487	its high specific surface area	458:487	its high specific surface area	458:487	With its high specific surface area and conductivity, CS-AuNPs Cry proved an excellent supporting material for diamine oxidase (DAO) immobilization.
34167007	4	42	theme	PB	717:718	arg1	current					730:736	The PB reduction current	713:736	The PB reduction current	713:736	The PB reduction current was measured during the hydrogen peroxide-releasing oxidation of histamine catalyzed by DAO.
34167007	8	43	with	shrimps	1146:1152	arg1	recoveries					1172:1181	satisfactory recoveries	1159:1181	satisfactory recoveries	1159:1181	The biosensor determined histamine levels in fish and shrimps with satisfactory recoveries, and the obtained results agreed with those obtained by ELISA.
34167007	0	44	theme	carbon	59:64	arg1	electrode					66:74	a screen-printed carbon electrode	42:74	a screen-printed carbon electrode modified with a chitosan-gold	42:104	An enzymatic histamine biosensor based on a screen-printed carbon electrode modified with a chitosan-gold nanoparticles composite cryogel on Prussian blue-coated multi-walled carbon nanotubes.
34167007	0	45	from	cryogel	130:136	arg1	nanotubes					182:190	Prussian blue-coated multi-walled carbon nanotubes	141:190	Prussian blue-coated multi-walled carbon nanotubes	141:190	An enzymatic histamine biosensor based on a screen-printed carbon electrode modified with a chitosan-gold nanoparticles composite cryogel on Prussian blue-coated multi-walled carbon nanotubes.
34167007	8	46	theme	satisfactory	1159:1170	arg1	recoveries					1172:1181	satisfactory recoveries	1159:1181	satisfactory recoveries	1159:1181	The biosensor determined histamine levels in fish and shrimps with satisfactory recoveries, and the obtained results agreed with those obtained by ELISA.
34167007	1	47	theme	carbon	338:343	arg1	nanotubes					345:353	multi-walled carbon nanotubes	325:353	multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry)	325:450	A histamine biosensor was developed based on a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry).
33675827	5	0	theme	slow	783:786	arg1	profile					811:817	slow and continuous release profile	783:817	slow and continuous release profile (200h) with 94.3%	783:835	The CH/ZA composite is of slow and continuous release profile (200h) with 94.3% as the maximum release percentage.
33675827	5	0	theme	slow	783:786	arg1	200h					820:823	200h	820:823	200h	820:823	The CH/ZA composite is of slow and continuous release profile (200h) with 94.3% as the maximum release percentage.
33675827	8	1	theme	cytotoxicity	1142:1153	arg1	studies					1155:1161	The cytotoxicity studies	1138:1161	The cytotoxicity studies on the normal cells	1138:1181	The cytotoxicity studies on the normal cells demonstrated a high safety value for the composite.
33675827	3	2	theme	isotherm	520:527	arg1	models					529:534	kinetic and isotherm models	508:534	kinetic and isotherm models	508:534	The loading behavior follows Pseudo-Second-order and Langmuir as kinetic and isotherm models.
33675827	3	2	theme	isotherm	520:527	arg1	Langmuir					496:503	Langmuir	496:503	Langmuir	496:503	The loading behavior follows Pseudo-Second-order and Langmuir as kinetic and isotherm models.
33675827	3	2	theme	isotherm	520:527	arg1	Pseudo-Second-order					472:490	Pseudo-Second-order	472:490	Pseudo-Second-order	472:490	The loading behavior follows Pseudo-Second-order and Langmuir as kinetic and isotherm models.
33675827	6	3	theme	non-Fickian	901:911	arg1	behavior					913:920	non-Fickian behavior	901:920	non-Fickian behavior involving both diffusion and erosion mechanisms	901:968	The release reactions are of non-Fickian behavior involving both diffusion and erosion mechanisms.
33675827	7	4	theme	epithelia	1114:1122	arg1	cells					1124:1128	the human bronchial epithelia cells	1094:1128	the human bronchial epithelia cells (NL20)	1094:1135	The loading of LVOX into CH/ZA induced its anti-inflammatory effect against the cytokine production (IL-6 and IL-8) within the human bronchial epithelia cells (NL20).
33675827	7	4	theme	epithelia	1114:1122	arg1	NL20					1131:1134	NL20	1131:1134	NL20	1131:1134	The loading of LVOX into CH/ZA induced its anti-inflammatory effect against the cytokine production (IL-6 and IL-8) within the human bronchial epithelia cells (NL20).
33675827	5	5	with	profile	811:817	arg1	%					835:835	94.3%	831:835	94.3%	831:835	The CH/ZA composite is of slow and continuous release profile (200h) with 94.3% as the maximum release percentage.
33675827	0	6	theme	anti-inflammatory	94:110	arg1	properties					112:121	its anti-inflammatory properties	90:121	its anti-inflammatory properties	90:121	Insight into chitosan/zeolite-A nanocomposite as an advanced carrier for levofloxacin and its anti-inflammatory properties; loading, release, and anti-inflammatory studies.
33675827	4	7	theme	exothermic	738:747	arg1	nature					749:754	spontaneous and exothermic nature	722:754	spontaneous and exothermic nature	722:754	The equilibrium studies, Gaussian energy (8.15 KJ/mol), and thermodynamic parameters demonstrate homogenous and monolayer loading by complex chemical and physical reactions that are of spontaneous and exothermic nature.
33675827	5	8	theme	CH/ZA	761:765	arg1	composite					767:775	The CH/ZA composite	757:775	The CH/ZA composite	757:775	The CH/ZA composite is of slow and continuous release profile (200h) with 94.3% as the maximum release percentage.
33675827	7	9	theme	human	1098:1102	arg1	epithelia					1114:1122	human bronchial epithelia	1098:1122	the human bronchial epithelia cells (NL20)	1094:1135	The loading of LVOX into CH/ZA induced its anti-inflammatory effect against the cytokine production (IL-6 and IL-8) within the human bronchial epithelia cells (NL20).
33675827	4	10	theme	chemical	678:685	arg1	reactions					700:708	complex chemical and physical reactions	670:708	complex chemical and physical reactions that are of spontaneous and exothermic nature	670:754	The equilibrium studies, Gaussian energy (8.15 KJ/mol), and thermodynamic parameters demonstrate homogenous and monolayer loading by complex chemical and physical reactions that are of spontaneous and exothermic nature.
33675827	7	11	theme	bronchial	1104:1112	arg1	epithelia					1114:1122	human bronchial epithelia	1098:1122	the human bronchial epithelia cells (NL20)	1094:1135	The loading of LVOX into CH/ZA induced its anti-inflammatory effect against the cytokine production (IL-6 and IL-8) within the human bronchial epithelia cells (NL20).
33675827	4	12	theme	complex	670:676	arg1	reactions					700:708	complex chemical and physical reactions	670:708	complex chemical and physical reactions that are of spontaneous and exothermic nature	670:754	The equilibrium studies, Gaussian energy (8.15 KJ/mol), and thermodynamic parameters demonstrate homogenous and monolayer loading by complex chemical and physical reactions that are of spontaneous and exothermic nature.
33675827	6	13	theme	release	876:882	arg1	reactions					884:892	The release reactions	872:892	The release reactions	872:892	The release reactions are of non-Fickian behavior involving both diffusion and erosion mechanisms.
33675827	4	14	theme	physical	691:698	arg1	reactions					700:708	complex chemical and physical reactions	670:708	complex chemical and physical reactions that are of spontaneous and exothermic nature	670:754	The equilibrium studies, Gaussian energy (8.15 KJ/mol), and thermodynamic parameters demonstrate homogenous and monolayer loading by complex chemical and physical reactions that are of spontaneous and exothermic nature.
33675827	1	15	theme	enhanced	280:287	arg1	properties					299:308	enhanced technical properties	280:308	enhanced technical properties	280:308	Chitosan/zeolite-A nanocomposite (CH/ZA) was synthesized as a potential carrier for levofloxacin (LVOX) of enhanced technical properties.
33675827	5	16	theme	release	852:858	arg1	percentage					860:869	the maximum release percentage	840:869	the maximum release percentage	840:869	The CH/ZA composite is of slow and continuous release profile (200h) with 94.3% as the maximum release percentage.
33675827	8	17	theme	high	1198:1201	arg1	value					1210:1214	a high safety value	1196:1214	a high safety value for the composite	1196:1232	The cytotoxicity studies on the normal cells demonstrated a high safety value for the composite.
33675827	4	18	theme	Gaussian	562:569	arg1	energy					571:576	Gaussian energy	562:576	Gaussian energy (8.15 KJ/mol)	562:590	The equilibrium studies, Gaussian energy (8.15 KJ/mol), and thermodynamic parameters demonstrate homogenous and monolayer loading by complex chemical and physical reactions that are of spontaneous and exothermic nature.
33675827	4	18	theme	Gaussian	562:569	arg1	KJ/mol					584:589	8.15 KJ/mol	579:589	8.15 KJ/mol	579:589	The equilibrium studies, Gaussian energy (8.15 KJ/mol), and thermodynamic parameters demonstrate homogenous and monolayer loading by complex chemical and physical reactions that are of spontaneous and exothermic nature.
33675827	2	19	theme	CH/ZA	315:319	arg1	composite					321:329	The CH/ZA composite	311:329	The CH/ZA composite	311:329	The CH/ZA composite displayed enhanced loading capacity (425 mg/g) as compared to chitosan (188.8 mg/g) and zeolite-A (234.6 mg/g).
33675827	4	20	theme	monolayer	649:657	arg1	loading					659:665	monolayer loading	649:665	monolayer loading	649:665	The equilibrium studies, Gaussian energy (8.15 KJ/mol), and thermodynamic parameters demonstrate homogenous and monolayer loading by complex chemical and physical reactions that are of spontaneous and exothermic nature.
33675827	1	21	theme	properties	299:308	arg1	LVOX					271:274	LVOX	271:274	LVOX	271:274	Chitosan/zeolite-A nanocomposite (CH/ZA) was synthesized as a potential carrier for levofloxacin (LVOX) of enhanced technical properties.
33675827	1	21	theme	properties	299:308	arg1	levofloxacin					257:268	levofloxacin	257:268	levofloxacin (LVOX) of enhanced technical properties	257:308	Chitosan/zeolite-A nanocomposite (CH/ZA) was synthesized as a potential carrier for levofloxacin (LVOX) of enhanced technical properties.
33675827	1	22	theme	Chitosan/zeolite-A	173:190	arg1	CH/ZA					207:211	CH/ZA	207:211	CH/ZA	207:211	Chitosan/zeolite-A nanocomposite (CH/ZA) was synthesized as a potential carrier for levofloxacin (LVOX) of enhanced technical properties.
33675827	1	22	theme	Chitosan/zeolite-A	173:190	arg1	nanocomposite					192:204	Chitosan/zeolite-A nanocomposite	173:204	Chitosan/zeolite-A nanocomposite (CH/ZA)	173:212	Chitosan/zeolite-A nanocomposite (CH/ZA) was synthesized as a potential carrier for levofloxacin (LVOX) of enhanced technical properties.
33675827	1	22	theme	Chitosan/zeolite-A	173:190	arg1	carrier					245:251	a potential carrier	233:251	a potential carrier for levofloxacin (LVOX) of enhanced technical properties	233:308	Chitosan/zeolite-A nanocomposite (CH/ZA) was synthesized as a potential carrier for levofloxacin (LVOX) of enhanced technical properties.
33675827	5	23	theme	continuous	792:801	arg1	profile					811:817	slow and continuous release profile	783:817	slow and continuous release profile (200h) with 94.3%	783:835	The CH/ZA composite is of slow and continuous release profile (200h) with 94.3% as the maximum release percentage.
33675827	5	23	theme	continuous	792:801	arg1	200h					820:823	200h	820:823	200h	820:823	The CH/ZA composite is of slow and continuous release profile (200h) with 94.3% as the maximum release percentage.
33675827	4	24	theme	spontaneous	722:732	arg1	nature					749:754	spontaneous and exothermic nature	722:754	spontaneous and exothermic nature	722:754	The equilibrium studies, Gaussian energy (8.15 KJ/mol), and thermodynamic parameters demonstrate homogenous and monolayer loading by complex chemical and physical reactions that are of spontaneous and exothermic nature.
33675827	6	25	dep	diffusion	937:945	arg1	mechanisms					959:968	mechanisms	959:968	mechanisms	959:968	The release reactions are of non-Fickian behavior involving both diffusion and erosion mechanisms.
33675827	3	26	theme	loading	447:453	arg1	behavior					455:462	The loading behavior	443:462	The loading behavior	443:462	The loading behavior follows Pseudo-Second-order and Langmuir as kinetic and isotherm models.
33675827	5	27	theme	release	803:809	arg1	profile					811:817	slow and continuous release profile	783:817	slow and continuous release profile (200h) with 94.3%	783:835	The CH/ZA composite is of slow and continuous release profile (200h) with 94.3% as the maximum release percentage.
33675827	5	27	theme	release	803:809	arg1	200h					820:823	200h	820:823	200h	820:823	The CH/ZA composite is of slow and continuous release profile (200h) with 94.3% as the maximum release percentage.
33675827	4	28	theme	equilibrium	541:551	arg1	studies					553:559	The equilibrium studies	537:559	The equilibrium studies	537:559	The equilibrium studies, Gaussian energy (8.15 KJ/mol), and thermodynamic parameters demonstrate homogenous and monolayer loading by complex chemical and physical reactions that are of spontaneous and exothermic nature.
33675827	8	29	theme	safety	1203:1208	arg1	value					1210:1214	a high safety value	1196:1214	a high safety value for the composite	1196:1232	The cytotoxicity studies on the normal cells demonstrated a high safety value for the composite.
33675827	5	30	theme	maximum	844:850	arg1	percentage					860:869	the maximum release percentage	840:869	the maximum release percentage	840:869	The CH/ZA composite is of slow and continuous release profile (200h) with 94.3% as the maximum release percentage.
33675827	7	31	dep	production	1060:1069	arg1	IL-8					1081:1084	IL-8	1081:1084	IL-8	1081:1084	The loading of LVOX into CH/ZA induced its anti-inflammatory effect against the cytokine production (IL-6 and IL-8) within the human bronchial epithelia cells (NL20).
33675827	7	31	dep	production	1060:1069	arg1	IL-6					1072:1075	IL-6	1072:1075	IL-6	1072:1075	The loading of LVOX into CH/ZA induced its anti-inflammatory effect against the cytokine production (IL-6 and IL-8) within the human bronchial epithelia cells (NL20).
33675827	1	32	theme	technical	289:297	arg1	properties					299:308	enhanced technical properties	280:308	enhanced technical properties	280:308	Chitosan/zeolite-A nanocomposite (CH/ZA) was synthesized as a potential carrier for levofloxacin (LVOX) of enhanced technical properties.
33675827	0	33	theme	advanced	52:59	arg1	studies					164:170	anti-inflammatory studies	146:170	anti-inflammatory studies	146:170	Insight into chitosan/zeolite-A nanocomposite as an advanced carrier for levofloxacin and its anti-inflammatory properties; loading, release, and anti-inflammatory studies.
33675827	0	33	theme	advanced	52:59	arg1	loading					124:130	loading	124:130	loading	124:130	Insight into chitosan/zeolite-A nanocomposite as an advanced carrier for levofloxacin and its anti-inflammatory properties; loading, release, and anti-inflammatory studies.
33675827	0	33	theme	advanced	52:59	arg1	release					133:139	release	133:139	release	133:139	Insight into chitosan/zeolite-A nanocomposite as an advanced carrier for levofloxacin and its anti-inflammatory properties; loading, release, and anti-inflammatory studies.
33675827	0	33	theme	advanced	52:59	arg1	carrier					61:67	an advanced carrier	49:67	an advanced carrier for levofloxacin and its anti-inflammatory properties	49:121	Insight into chitosan/zeolite-A nanocomposite as an advanced carrier for levofloxacin and its anti-inflammatory properties; loading, release, and anti-inflammatory studies.
33675827	0	34	theme	anti-inflammatory	146:162	arg1	studies					164:170	anti-inflammatory studies	146:170	anti-inflammatory studies	146:170	Insight into chitosan/zeolite-A nanocomposite as an advanced carrier for levofloxacin and its anti-inflammatory properties; loading, release, and anti-inflammatory studies.
33675827	0	34	theme	anti-inflammatory	146:162	arg1	loading					124:130	loading	124:130	loading	124:130	Insight into chitosan/zeolite-A nanocomposite as an advanced carrier for levofloxacin and its anti-inflammatory properties; loading, release, and anti-inflammatory studies.
33675827	0	34	theme	anti-inflammatory	146:162	arg1	release					133:139	release	133:139	release	133:139	Insight into chitosan/zeolite-A nanocomposite as an advanced carrier for levofloxacin and its anti-inflammatory properties; loading, release, and anti-inflammatory studies.
33675827	0	34	theme	anti-inflammatory	146:162	arg1	carrier					61:67	an advanced carrier	49:67	an advanced carrier for levofloxacin and its anti-inflammatory properties	49:121	Insight into chitosan/zeolite-A nanocomposite as an advanced carrier for levofloxacin and its anti-inflammatory properties; loading, release, and anti-inflammatory studies.
33675827	3	35	theme	kinetic	508:514	arg1	models					529:534	kinetic and isotherm models	508:534	kinetic and isotherm models	508:534	The loading behavior follows Pseudo-Second-order and Langmuir as kinetic and isotherm models.
33675827	3	35	theme	kinetic	508:514	arg1	Langmuir					496:503	Langmuir	496:503	Langmuir	496:503	The loading behavior follows Pseudo-Second-order and Langmuir as kinetic and isotherm models.
33675827	3	35	theme	kinetic	508:514	arg1	Pseudo-Second-order					472:490	Pseudo-Second-order	472:490	Pseudo-Second-order	472:490	The loading behavior follows Pseudo-Second-order and Langmuir as kinetic and isotherm models.
33675827	7	36	theme	anti-inflammatory	1014:1030	arg1	effect					1032:1037	its anti-inflammatory effect	1010:1037	its anti-inflammatory effect against the cytokine production (IL-6 and IL-8)	1010:1085	The loading of LVOX into CH/ZA induced its anti-inflammatory effect against the cytokine production (IL-6 and IL-8) within the human bronchial epithelia cells (NL20).
33675827	2	37	theme	loading	350:356	arg1	capacity					358:365	enhanced loading capacity	341:365	enhanced loading capacity (425 mg/g)	341:376	The CH/ZA composite displayed enhanced loading capacity (425 mg/g) as compared to chitosan (188.8 mg/g) and zeolite-A (234.6 mg/g).
33675827	2	37	theme	loading	350:356	arg1	425 mg/g					368:375	425 mg/g	368:375	425 mg/g	368:375	The CH/ZA composite displayed enhanced loading capacity (425 mg/g) as compared to chitosan (188.8 mg/g) and zeolite-A (234.6 mg/g).
33675827	1	38	theme	potential	235:243	arg1	nanocomposite					192:204	Chitosan/zeolite-A nanocomposite	173:204	Chitosan/zeolite-A nanocomposite (CH/ZA)	173:212	Chitosan/zeolite-A nanocomposite (CH/ZA) was synthesized as a potential carrier for levofloxacin (LVOX) of enhanced technical properties.
33675827	1	38	theme	potential	235:243	arg1	carrier					245:251	a potential carrier	233:251	a potential carrier for levofloxacin (LVOX) of enhanced technical properties	233:308	Chitosan/zeolite-A nanocomposite (CH/ZA) was synthesized as a potential carrier for levofloxacin (LVOX) of enhanced technical properties.
33675827	7	39	theme	cytokine	1051:1058	arg1	production					1060:1069	the cytokine production	1047:1069	the cytokine production (IL-6 and IL-8)	1047:1085	The loading of LVOX into CH/ZA induced its anti-inflammatory effect against the cytokine production (IL-6 and IL-8) within the human bronchial epithelia cells (NL20).
33675827	2	40	theme	enhanced	341:348	arg1	capacity					358:365	enhanced loading capacity	341:365	enhanced loading capacity (425 mg/g)	341:376	The CH/ZA composite displayed enhanced loading capacity (425 mg/g) as compared to chitosan (188.8 mg/g) and zeolite-A (234.6 mg/g).
33675827	2	40	theme	enhanced	341:348	arg1	425 mg/g					368:375	425 mg/g	368:375	425 mg/g	368:375	The CH/ZA composite displayed enhanced loading capacity (425 mg/g) as compared to chitosan (188.8 mg/g) and zeolite-A (234.6 mg/g).
33675827	4	41	theme	thermodynamic	597:609	arg1	parameters					611:620	thermodynamic parameters	597:620	thermodynamic parameters	597:620	The equilibrium studies, Gaussian energy (8.15 KJ/mol), and thermodynamic parameters demonstrate homogenous and monolayer loading by complex chemical and physical reactions that are of spontaneous and exothermic nature.
33675827	8	42	from	studies	1155:1161	arg1	cells					1177:1181	the normal cells	1166:1181	the normal cells	1166:1181	The cytotoxicity studies on the normal cells demonstrated a high safety value for the composite.
33675827	8	43	theme	normal	1170:1175	arg1	cells					1177:1181	the normal cells	1166:1181	the normal cells	1166:1181	The cytotoxicity studies on the normal cells demonstrated a high safety value for the composite.
33675827	7	44	theme	LVOX	986:989	arg1	loading					975:981	The loading	971:981	The loading of LVOX into CH/ZA	971:1000	The loading of LVOX into CH/ZA induced its anti-inflammatory effect against the cytokine production (IL-6 and IL-8) within the human bronchial epithelia cells (NL20).
32009638	2	0	theme	great	389:393	arg1	potential					395:403	great potential	389:403	great potential	389:403	Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases).
32009638	5	1	from	composition	826:836	arg1	plasma					864:869	plasma	864:869	plasma	864:869	In addition, the structure of IgG N-glycan is clearly separated, and glycan composition and relative abundance in plasma are characterized.
32009638	3	2	theme	ultra-performance	597:613	arg1	UPLC					638:641	UPLC	638:641	UPLC	638:641	IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC).
32009638	3	2	theme	ultra-performance	597:613	arg1	chromatography					622:635	ultra-performance liquid chromatography	597:635	hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC)	550:642	IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC).
32009638	2	3	theme	chronic	350:356	arg1	diseases					358:365	several common chronic diseases	335:365	several common chronic diseases	335:365	Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases).
32009638	2	4	contain	have	384:387	arg1	N-glycans					303:311	Alternative IgG N-glycans	287:311	Alternative IgG N-glycans	287:311	Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases).
32009638	2	4	contain	have	384:387	arg2	potential					395:403	great potential	389:403	great potential	389:403	Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases).
32009638	5	5	theme	N-glycan	784:791	arg1	structure					767:775	the structure	763:775	the structure of IgG N-glycan	763:791	In addition, the structure of IgG N-glycan is clearly separated, and glycan composition and relative abundance in plasma are characterized.
32009638	3	6	theme	interaction	562:572	arg1	HILIC					590:594	HILIC	590:594	HILIC	590:594	IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC).
32009638	3	6	theme	interaction	562:572	arg1	chromatography					574:587	hydrophilic interaction chromatography	550:587	hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC)	550:642	IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC).
32009638	1	7	theme	next-generation	185:199	arg1	biomarkers					201:210	next-generation biomarkers	185:210	next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine	185:284	Glycomics is a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine.
32009638	5	8	theme	relative	842:849	arg1	abundance					851:859	relative abundance	842:859	relative abundance	842:859	In addition, the structure of IgG N-glycan is clearly separated, and glycan composition and relative abundance in plasma are characterized.
32009638	5	9	from	abundance	851:859	arg1	plasma					864:869	plasma	864:869	plasma	864:869	In addition, the structure of IgG N-glycan is clearly separated, and glycan composition and relative abundance in plasma are characterized.
32009638	5	10	theme	glycan	819:824	arg1	composition					826:836	glycan composition	819:836	glycan composition	819:836	In addition, the structure of IgG N-glycan is clearly separated, and glycan composition and relative abundance in plasma are characterized.
32009638	3	11	theme	chromatography	574:587	arg1	method					540:545	the method	536:545	the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC)	536:642	IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC).
32009638	0	12	theme	G	15:15	arg1	Analysis					26:33	Immunoglobulin G N-Glycan Analysis	0:33	Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography.	0:77	Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography.
32009638	1	13	theme	new	94:96	arg1	subspecialty					98:109	a new subspecialty	92:109	a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine	92:284	Glycomics is a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine.
32009638	1	13	theme	new	94:96	arg1	Glycomics					79:87	Glycomics	79:87	Glycomics	79:87	Glycomics is a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine.
32009638	4	14	theme	relative	718:725	arg1	accuracy					740:747	high relative quantitative accuracy	713:747	high relative quantitative accuracy	713:747	UPLC is a stable detection technology with good reproducibility and high relative quantitative accuracy.
32009638	0	15	theme	Immunoglobulin	0:13	arg1	Analysis					26:33	Immunoglobulin G N-Glycan Analysis	0:33	Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography.	0:77	Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography.
32009638	2	16	theme	common	343:348	arg1	diseases					358:365	several common chronic diseases	335:365	several common chronic diseases	335:365	Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases).
32009638	2	17	theme	clinical	408:415	arg1	applications					417:428	clinical applications	408:428	clinical applications (i.e., biomarkers for diagnosis and prediction of diseases)	408:488	Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases).
32009638	2	18	theme	several	335:341	arg1	diseases					358:365	several common chronic diseases	335:365	several common chronic diseases	335:365	Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases).
32009638	3	19	theme	IgG	491:493	arg1	N-glycans					495:503	IgG N-glycans	491:503	IgG N-glycans	491:503	IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC).
32009638	0	20	theme	N-Glycan	17:24	arg1	Analysis					26:33	Immunoglobulin G N-Glycan Analysis	0:33	Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography.	0:77	Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography.
32009638	1	21	theme	omics	114:118	arg1	research					127:134	omics system research	114:134	omics system research	114:134	Glycomics is a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine.
32009638	4	22	theme	detection	662:670	arg1	technology					672:681	a stable detection technology	653:681	a stable detection technology with good reproducibility and high relative quantitative accuracy	653:747	UPLC is a stable detection technology with good reproducibility and high relative quantitative accuracy.
32009638	4	22	theme	detection	662:670	arg1	UPLC					645:648	UPLC	645:648	UPLC	645:648	UPLC is a stable detection technology with good reproducibility and high relative quantitative accuracy.
32009638	0	23	theme	Ultra-Performance	38:54	arg1	Chromatography					63:76	Ultra-Performance Liquid Chromatography	38:76	Ultra-Performance Liquid Chromatography	38:76	Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography.
32009638	4	24	theme	good	688:691	arg1	reproducibility					693:707	good reproducibility	688:707	good reproducibility	688:707	UPLC is a stable detection technology with good reproducibility and high relative quantitative accuracy.
32009638	2	25	dep	biomarkers	437:446	arg1	i.e.					431:434	i.e.	431:434	i.e.	431:434	Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases).
32009638	1	26	theme	disease	216:222	arg1	susceptibility					224:237	disease susceptibility	216:237	disease susceptibility	216:237	Glycomics is a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine.
32009638	1	27	theme	drug	240:243	arg1	discovery					252:260	drug target discovery	240:260	drug target discovery	240:260	Glycomics is a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine.
32009638	5	28	theme	IgG	780:782	arg1	N-glycan					784:791	IgG N-glycan	780:791	IgG N-glycan	780:791	In addition, the structure of IgG N-glycan is clearly separated, and glycan composition and relative abundance in plasma are characterized.
32009638	1	29	theme	target	245:250	arg1	discovery					252:260	drug target discovery	240:260	drug target discovery	240:260	Glycomics is a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine.
32009638	1	30	theme	system	120:125	arg1	research					127:134	omics system research	114:134	omics system research	114:134	Glycomics is a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine.
32009638	0	31	theme	Liquid	56:61	arg1	Chromatography					63:76	Ultra-Performance Liquid Chromatography	38:76	Ultra-Performance Liquid Chromatography	38:76	Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography.
32009638	3	32	dep	chromatography	574:587	arg1	UPLC					638:641	UPLC	638:641	UPLC	638:641	IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC).
32009638	3	32	dep	chromatography	574:587	arg1	chromatography					622:635	ultra-performance liquid chromatography	597:635	hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC)	550:642	IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC).
32009638	3	33	theme	liquid	615:620	arg1	UPLC					638:641	UPLC	638:641	UPLC	638:641	IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC).
32009638	3	33	theme	liquid	615:620	arg1	chromatography					622:635	ultra-performance liquid chromatography	597:635	hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC)	550:642	IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC).
32009638	2	34	dep	applications	417:428	arg1	biomarkers					437:446	biomarkers	437:446	biomarkers for diagnosis and prediction of diseases	437:487	Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases).
32009638	2	35	theme	IgG	299:301	arg1	N-glycans					303:311	Alternative IgG N-glycans	287:311	Alternative IgG N-glycans	287:311	Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases).
32009638	4	36	theme	quantitative	727:738	arg1	accuracy					740:747	high relative quantitative accuracy	713:747	high relative quantitative accuracy	713:747	UPLC is a stable detection technology with good reproducibility and high relative quantitative accuracy.
32009638	4	37	with	technology	672:681	arg1	accuracy					740:747	high relative quantitative accuracy	713:747	high relative quantitative accuracy	713:747	UPLC is a stable detection technology with good reproducibility and high relative quantitative accuracy.
32009638	4	37	with	technology	672:681	arg1	reproducibility					693:707	good reproducibility	688:707	good reproducibility	688:707	UPLC is a stable detection technology with good reproducibility and high relative quantitative accuracy.
32009638	2	38	theme	Alternative	287:297	arg1	N-glycans					303:311	Alternative IgG N-glycans	287:311	Alternative IgG N-glycans	287:311	Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases).
32009638	3	39	theme	hydrophilic	550:560	arg1	HILIC					590:594	HILIC	590:594	HILIC	590:594	IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC).
32009638	3	39	theme	hydrophilic	550:560	arg1	chromatography					574:587	hydrophilic interaction chromatography	550:587	hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC)	550:642	IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC).
32009638	1	40	theme	significant	148:158	arg1	potential					160:168	significant potential	148:168	significant potential	148:168	Glycomics is a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine.
32009638	1	41	from	subspecialty	98:109	arg1	research					127:134	omics system research	114:134	omics system research	114:134	Glycomics is a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine.
32009638	4	42	theme	stable	655:660	arg1	technology					672:681	a stable detection technology	653:681	a stable detection technology with good reproducibility and high relative quantitative accuracy	653:747	UPLC is a stable detection technology with good reproducibility and high relative quantitative accuracy.
32009638	4	42	theme	stable	655:660	arg1	UPLC					645:648	UPLC	645:648	UPLC	645:648	UPLC is a stable detection technology with good reproducibility and high relative quantitative accuracy.
32009638	4	43	theme	high	713:716	arg1	accuracy					740:747	high relative quantitative accuracy	713:747	high relative quantitative accuracy	713:747	UPLC is a stable detection technology with good reproducibility and high relative quantitative accuracy.
32009638	2	44	theme	diseases	480:487	arg1	prediction					466:475	prediction	466:475	prediction	466:475	Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases).
32009638	2	44	theme	diseases	480:487	arg1	diagnosis					452:460	diagnosis	452:460	diagnosis	452:460	Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases).
32009638	1	45	theme	precision	267:275	arg1	medicine					277:284	precision medicine	267:284	precision medicine	267:284	Glycomics is a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine.
33880661	8	0	theme	clotting	1246:1253	arg1	time					1255:1258	minimum clotting time	1238:1258	minimum clotting time of 20 ± 3 s	1238:1270	Aerosol deposited scaffolds showed minimum clotting time of 20 ± 3 s and bleeding time of 38 ± 4 s, which was significantly lower compared to the scaffolds without aerosol treatment.
33880661	5	1	theme	higher	753:758	arg1	affinity					768:775	higher binding affinity	753:775	higher binding affinity of collagen toward the human blood platelets and erythrocytes	753:837	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	6	2	theme	binding	1002:1008	arg1	response					1010:1017	higher binding response	995:1017	higher binding response for platelets	995:1031	Scaffolds showed higher binding response for platelets than erythrocytes, while fibrinogen and thrombin showed no or limited interaction.
33880661	4	3	theme	aerosol	680:686	arg1	size					630:633	pore size	625:633	pore size of ~30 μm	625:643	Scanning electron microscope showed multilayered porosity with pore size of ~30 μm and mushroom-like fibril growth of aerosol.
33880661	4	3	theme	aerosol	680:686	arg1	growth					670:675	mushroom-like fibril growth	649:675	mushroom-like fibril growth	649:675	Scanning electron microscope showed multilayered porosity with pore size of ~30 μm and mushroom-like fibril growth of aerosol.
33880661	2	4	theme	scaffolds	303:311	arg1	surface					292:298	the surface	288:298	the surface of scaffolds	288:311	Fibrinogen and thrombin aerosol were deposited over the surface of scaffolds to enhance hemostasis and wound healing.
33880661	8	5	theme	s	1300:1300	arg1	time					1285:1288	bleeding time	1276:1288	bleeding time of 38 ± 4 s, which was significantly lower	1276:1331	Aerosol deposited scaffolds showed minimum clotting time of 20 ± 3 s and bleeding time of 38 ± 4 s, which was significantly lower compared to the scaffolds without aerosol treatment.
33880661	8	5	theme	s	1300:1300	arg1	time					1255:1258	minimum clotting time	1238:1258	minimum clotting time of 20 ± 3 s	1238:1270	Aerosol deposited scaffolds showed minimum clotting time of 20 ± 3 s and bleeding time of 38 ± 4 s, which was significantly lower compared to the scaffolds without aerosol treatment.
33880661	10	6	theme	crucial	1611:1617	arg1	role					1619:1622	a crucial role	1609:1622	a crucial role	1609:1622	In vivo studies revealed that chitosan had a crucial role in the inflammatory phase, while collagen played an important role in the proliferation and maturation phase.
33880661	5	7	theme	surface	717:723	arg1	resonance					733:741	surface plasmon resonance	717:741	surface plasmon resonance	717:741	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	9	8	with	scaffolds	1414:1422	arg1	concentration					1433:1445	2:1 concentration	1429:1445	2:1 concentration of chitosan/collagen	1429:1466	Aerosol deposited composite scaffolds with 2:1 concentration of chitosan/collagen showed complete wound contraction by day 14, while 50% was observed in case of the control group.
33880661	8	9	theme	s	1270:1270	arg1	time					1285:1288	bleeding time	1276:1288	bleeding time of 38 ± 4 s, which was significantly lower	1276:1331	Aerosol deposited scaffolds showed minimum clotting time of 20 ± 3 s and bleeding time of 38 ± 4 s, which was significantly lower compared to the scaffolds without aerosol treatment.
33880661	8	9	theme	s	1270:1270	arg1	time					1255:1258	minimum clotting time	1238:1258	minimum clotting time of 20 ± 3 s	1238:1270	Aerosol deposited scaffolds showed minimum clotting time of 20 ± 3 s and bleeding time of 38 ± 4 s, which was significantly lower compared to the scaffolds without aerosol treatment.
33880661	5	10	theme	collagen	780:787	arg1	affinity					768:775	higher binding affinity	753:775	higher binding affinity of collagen toward the human blood platelets and erythrocytes	753:837	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	8	11	theme	bleeding	1276:1283	arg1	time					1285:1288	bleeding time	1276:1288	bleeding time of 38 ± 4 s, which was significantly lower	1276:1331	Aerosol deposited scaffolds showed minimum clotting time of 20 ± 3 s and bleeding time of 38 ± 4 s, which was significantly lower compared to the scaffolds without aerosol treatment.
33880661	10	12	theme	inflammatory	1631:1642	arg1	phase					1644:1648	the inflammatory phase	1627:1648	the inflammatory phase	1627:1648	In vivo studies revealed that chitosan had a crucial role in the inflammatory phase, while collagen played an important role in the proliferation and maturation phase.
33880661	11	13	theme	potential	1837:1845	arg1	candidate					1847:1855	a potential candidate	1835:1855	a potential candidate for enhanced hemostasis and wound healing applications	1835:1910	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	11	13	theme	potential	1837:1845	arg1	scaffolds					1794:1802	the fabricated 3D composite scaffolds	1766:1802	the fabricated 3D composite scaffolds with bioactive moieties	1766:1826	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	5	14	theme	blood	806:810	arg1	platelets					812:820	the human blood platelets	796:820	the human blood platelets	796:820	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	1	15	theme	gel	221:223	arg1	solutions					225:233	gel solutions	221:233	gel solutions	221:233	Fabrication of 3D composite scaffolds was carried out by lyophilization of variable concentrations of collagen and chitosan gel solutions.
33880661	11	16	theme	wound	1885:1889	arg1	healing					1891:1897	wound healing	1885:1897	wound healing	1885:1897	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	5	17	theme	blood	912:916	arg1	concentration					923:935	blood cell concentration	912:935	blood cell concentration from 480.8 to 886.4 RU for erythrocytes	912:975	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	7	18	theme	blood	1124:1128	arg1	sorption					1130:1137	Highest blood sorption	1116:1137	Highest blood sorption of 83 ± 4%	1116:1148	Highest blood sorption of 83 ± 4% was observed in case of aerosol deposited scaffolds.
33880661	8	19	theme	±	1296:1296	arg1	s					1300:1300	38 ± 4 s	1293:1300	38 ± 4 s	1293:1300	Aerosol deposited scaffolds showed minimum clotting time of 20 ± 3 s and bleeding time of 38 ± 4 s, which was significantly lower compared to the scaffolds without aerosol treatment.
33880661	11	20	theme	hemostasis	1870:1879	arg1	applications					1899:1910	enhanced hemostasis and wound healing applications	1861:1910	enhanced hemostasis and wound healing applications	1861:1910	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	7	21	theme	4	1147:1147	arg1	±					1145:1145	±	1145:1145	±	1145:1145	Highest blood sorption of 83 ± 4% was observed in case of aerosol deposited scaffolds.
33880661	9	22	theme	control	1551:1557	arg1	group					1559:1563	the control group	1547:1563	the control group	1547:1563	Aerosol deposited composite scaffolds with 2:1 concentration of chitosan/collagen showed complete wound contraction by day 14, while 50% was observed in case of the control group.
33880661	7	23	theme	83	1142:1143	arg1	±					1145:1145	±	1145:1145	±	1145:1145	Highest blood sorption of 83 ± 4% was observed in case of aerosol deposited scaffolds.
33880661	3	24	theme	Composite	354:362	arg1	scaffolds					364:372	Composite scaffolds	354:372	Composite scaffolds	354:372	Composite scaffolds were characterized using differential scanning calorimetry, thermogravimetric analysis, and Fourier-transform infrared spectrophotometer to ascertain the aerosol deposition and stability.
33880661	11	25	theme	composite	1784:1792	arg1	scaffolds					1794:1802	the fabricated 3D composite scaffolds	1766:1802	the fabricated 3D composite scaffolds with bioactive moieties	1766:1826	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	11	25	theme	composite	1784:1792	arg1	candidate					1847:1855	a potential candidate	1835:1855	a potential candidate for enhanced hemostasis and wound healing applications	1835:1910	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	10	26	dep	In	1566:1567	arg1	vivo					1569:1572	vivo	1569:1572	vivo	1569:1572	In vivo studies revealed that chitosan had a crucial role in the inflammatory phase, while collagen played an important role in the proliferation and maturation phase.
33880661	5	27	theme	cell	918:921	arg1	concentration					923:935	blood cell concentration	912:935	blood cell concentration from 480.8 to 886.4 RU for erythrocytes	912:975	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	1	28	theme	variable	172:179	arg1	concentrations					181:194	variable concentrations	172:194	variable concentrations of collagen and chitosan gel solutions	172:233	Fabrication of 3D composite scaffolds was carried out by lyophilization of variable concentrations of collagen and chitosan gel solutions.
33880661	6	29	theme	limited	1095:1101	arg1	interaction					1103:1113	limited interaction	1095:1113	limited interaction	1095:1113	Scaffolds showed higher binding response for platelets than erythrocytes, while fibrinogen and thrombin showed no or limited interaction.
33880661	4	30	theme	multilayered	598:609	arg1	porosity					611:618	multilayered porosity	598:618	multilayered porosity with pore size of ~30 μm and mushroom-like fibril growth of aerosol	598:686	Scanning electron microscope showed multilayered porosity with pore size of ~30 μm and mushroom-like fibril growth of aerosol.
33880661	5	31	theme	detailed	691:698	arg1	investigation					700:712	A detailed investigation	689:712	A detailed investigation by surface plasmon resonance	689:741	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	10	32	theme	proliferation	1698:1710	arg1	phase					1727:1731	the proliferation and maturation phase	1694:1731	the proliferation and maturation phase	1694:1731	In vivo studies revealed that chitosan had a crucial role in the inflammatory phase, while collagen played an important role in the proliferation and maturation phase.
33880661	5	33	from	increase	900:907	arg1	RU					957:958	480.8 to 886.4 RU	942:958	480.8 to 886.4 RU	942:958	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	5	33	from	increase	900:907	arg1	concentration					923:935	blood cell concentration	912:935	blood cell concentration from 480.8 to 886.4 RU for erythrocytes	912:975	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	4	34	theme	Scanning	562:569	arg1	microscope					580:589	Scanning electron microscope	562:589	Scanning electron microscope	562:589	Scanning electron microscope showed multilayered porosity with pore size of ~30 μm and mushroom-like fibril growth of aerosol.
33880661	8	35	dep	showed	1231:1236	arg1	compared					1333:1340	compared	1333:1340	showed minimum clotting time of 20 ± 3 s and bleeding time of 38 ± 4 s, which was significantly lower compared to the scaffolds without aerosol treatment	1231:1383	Aerosol deposited scaffolds showed minimum clotting time of 20 ± 3 s and bleeding time of 38 ± 4 s, which was significantly lower compared to the scaffolds without aerosol treatment.
33880661	3	36	theme	infrared	484:491	arg1	spectrophotometer					493:509	Fourier-transform infrared spectrophotometer	466:509	Fourier-transform infrared spectrophotometer	466:509	Composite scaffolds were characterized using differential scanning calorimetry, thermogravimetric analysis, and Fourier-transform infrared spectrophotometer to ascertain the aerosol deposition and stability.
33880661	9	37	theme	deposited	1394:1402	arg1	scaffolds					1414:1422	Aerosol deposited composite scaffolds	1386:1422	Aerosol deposited composite scaffolds with 2:1 concentration of chitosan/collagen	1386:1466	Aerosol deposited composite scaffolds with 2:1 concentration of chitosan/collagen showed complete wound contraction by day 14, while 50% was observed in case of the control group.
33880661	3	38	theme	scanning	412:419	arg1	calorimetry					421:431	differential scanning calorimetry	399:431	differential scanning calorimetry	399:431	Composite scaffolds were characterized using differential scanning calorimetry, thermogravimetric analysis, and Fourier-transform infrared spectrophotometer to ascertain the aerosol deposition and stability.
33880661	0	39	theme	Three-Dimensional	15:31	arg1	Composite					43:51	Three-Dimensional Bioactive Composite	15:51	Three-Dimensional Bioactive Composite	15:51	Fabrication of Three-Dimensional Bioactive Composite Scaffolds for Hemostasis and Wound Healing.
33880661	1	40	theme	composite	115:123	arg1	scaffolds					125:133	3D composite scaffolds	112:133	3D composite scaffolds	112:133	Fabrication of 3D composite scaffolds was carried out by lyophilization of variable concentrations of collagen and chitosan gel solutions.
33880661	1	41	dep	collagen	199:206	arg1	solutions					225:233	gel solutions	221:233	gel solutions	221:233	Fabrication of 3D composite scaffolds was carried out by lyophilization of variable concentrations of collagen and chitosan gel solutions.
33880661	10	42	theme	maturation	1716:1725	arg1	phase					1727:1731	the proliferation and maturation phase	1694:1731	the proliferation and maturation phase	1694:1731	In vivo studies revealed that chitosan had a crucial role in the inflammatory phase, while collagen played an important role in the proliferation and maturation phase.
33880661	0	43	theme	Composite	43:51	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of Three-Dimensional Bioactive Composite	0:51	Fabrication of Three-Dimensional Bioactive Composite Scaffolds for Hemostasis and Wound Healing.
33880661	9	44	theme	2:1	1429:1431	arg1	concentration					1433:1445	2:1 concentration	1429:1445	2:1 concentration of chitosan/collagen	1429:1466	Aerosol deposited composite scaffolds with 2:1 concentration of chitosan/collagen showed complete wound contraction by day 14, while 50% was observed in case of the control group.
33880661	11	45	theme	present	1738:1744	arg1	study					1746:1750	The present study	1734:1750	The present study	1734:1750	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	5	46	dep	886.4	951:955	arg1	to					948:949	to	948:949	to	948:949	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	4	47	with	porosity	611:618	arg1	size					630:633	pore size	625:633	pore size of ~30 μm	625:643	Scanning electron microscope showed multilayered porosity with pore size of ~30 μm and mushroom-like fibril growth of aerosol.
33880661	4	47	with	porosity	611:618	arg1	growth					670:675	mushroom-like fibril growth	649:675	mushroom-like fibril growth	649:675	Scanning electron microscope showed multilayered porosity with pore size of ~30 μm and mushroom-like fibril growth of aerosol.
33880661	7	48	theme	deposited	1182:1190	arg1	scaffolds					1192:1200	aerosol deposited scaffolds	1174:1200	aerosol deposited scaffolds	1174:1200	Highest blood sorption of 83 ± 4% was observed in case of aerosol deposited scaffolds.
33880661	11	49	theme	3D	1781:1782	arg1	scaffolds					1794:1802	the fabricated 3D composite scaffolds	1766:1802	the fabricated 3D composite scaffolds with bioactive moieties	1766:1826	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	11	49	theme	3D	1781:1782	arg1	candidate					1847:1855	a potential candidate	1835:1855	a potential candidate for enhanced hemostasis and wound healing applications	1835:1910	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	8	50	theme	Aerosol	1203:1209	arg1	scaffolds					1221:1229	Aerosol deposited scaffolds	1203:1229	Aerosol deposited scaffolds	1203:1229	Aerosol deposited scaffolds showed minimum clotting time of 20 ± 3 s and bleeding time of 38 ± 4 s, which was significantly lower compared to the scaffolds without aerosol treatment.
33880661	9	51	theme	wound	1484:1488	arg1	contraction					1490:1500	complete wound contraction	1475:1500	complete wound contraction	1475:1500	Aerosol deposited composite scaffolds with 2:1 concentration of chitosan/collagen showed complete wound contraction by day 14, while 50% was observed in case of the control group.
33880661	8	52	theme	minimum	1238:1244	arg1	time					1255:1258	minimum clotting time	1238:1258	minimum clotting time of 20 ± 3 s	1238:1270	Aerosol deposited scaffolds showed minimum clotting time of 20 ± 3 s and bleeding time of 38 ± 4 s, which was significantly lower compared to the scaffolds without aerosol treatment.
33880661	4	53	theme	fibril	663:668	arg1	growth					670:675	mushroom-like fibril growth	649:675	mushroom-like fibril growth	649:675	Scanning electron microscope showed multilayered porosity with pore size of ~30 μm and mushroom-like fibril growth of aerosol.
33880661	5	54	theme	binding	760:766	arg1	affinity					768:775	higher binding affinity	753:775	higher binding affinity of collagen toward the human blood platelets and erythrocytes	753:837	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	6	55	theme	higher	995:1000	arg1	response					1010:1017	higher binding response	995:1017	higher binding response for platelets	995:1031	Scaffolds showed higher binding response for platelets than erythrocytes, while fibrinogen and thrombin showed no or limited interaction.
33880661	7	56	theme	aerosol	1174:1180	arg1	scaffolds					1192:1200	aerosol deposited scaffolds	1174:1200	aerosol deposited scaffolds	1174:1200	Highest blood sorption of 83 ± 4% was observed in case of aerosol deposited scaffolds.
33880661	1	57	theme	concentrations	181:194	arg1	lyophilization					154:167	lyophilization	154:167	lyophilization of variable concentrations of collagen and chitosan gel solutions	154:233	Fabrication of 3D composite scaffolds was carried out by lyophilization of variable concentrations of collagen and chitosan gel solutions.
33880661	5	58	theme	plasmon	725:731	arg1	resonance					733:741	surface plasmon resonance	717:741	surface plasmon resonance	717:741	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	2	59	theme	wound	339:343	arg1	healing					345:351	wound healing	339:351	wound healing	339:351	Fibrinogen and thrombin aerosol were deposited over the surface of scaffolds to enhance hemostasis and wound healing.
33880661	1	60	theme	collagen	199:206	arg1	concentrations					181:194	variable concentrations	172:194	variable concentrations of collagen and chitosan gel solutions	172:233	Fabrication of 3D composite scaffolds was carried out by lyophilization of variable concentrations of collagen and chitosan gel solutions.
33880661	11	61	theme	enhanced	1861:1868	arg1	applications					1899:1910	enhanced hemostasis and wound healing applications	1861:1910	enhanced hemostasis and wound healing applications	1861:1910	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	5	62	theme	human	800:804	arg1	platelets					812:820	the human blood platelets	796:820	the human blood platelets	796:820	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	1	63	theme	chitosan	212:219	arg1	concentrations					181:194	variable concentrations	172:194	variable concentrations of collagen and chitosan gel solutions	172:233	Fabrication of 3D composite scaffolds was carried out by lyophilization of variable concentrations of collagen and chitosan gel solutions.
33880661	2	64	dep	Fibrinogen	236:245	arg1	aerosol					260:266	aerosol	260:266	aerosol	260:266	Fibrinogen and thrombin aerosol were deposited over the surface of scaffolds to enhance hemostasis and wound healing.
33880661	10	65	theme	important	1676:1684	arg1	role					1686:1689	an important role	1673:1689	an important role	1673:1689	In vivo studies revealed that chitosan had a crucial role in the inflammatory phase, while collagen played an important role in the proliferation and maturation phase.
33880661	7	66	theme	%	1148:1148	arg1	sorption					1130:1137	Highest blood sorption	1116:1137	Highest blood sorption of 83 ± 4%	1116:1148	Highest blood sorption of 83 ± 4% was observed in case of aerosol deposited scaffolds.
33880661	11	67	theme	healing	1891:1897	arg1	applications					1899:1910	enhanced hemostasis and wound healing applications	1861:1910	enhanced hemostasis and wound healing applications	1861:1910	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	1	68	theme	scaffolds	125:133	arg1	Fabrication					97:107	Fabrication	97:107	Fabrication of 3D composite scaffolds	97:133	Fabrication of 3D composite scaffolds was carried out by lyophilization of variable concentrations of collagen and chitosan gel solutions.
33880661	7	69	theme	Highest	1116:1122	arg1	sorption					1130:1137	Highest blood sorption	1116:1137	Highest blood sorption of 83 ± 4%	1116:1148	Highest blood sorption of 83 ± 4% was observed in case of aerosol deposited scaffolds.
33880661	11	70	theme	bioactive	1809:1817	arg1	moieties					1819:1826	bioactive moieties	1809:1826	bioactive moieties	1809:1826	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	0	71	theme	Wound	82:86	arg1	Healing					88:94	Wound Healing	82:94	Wound Healing	82:94	Fabrication of Three-Dimensional Bioactive Composite Scaffolds for Hemostasis and Wound Healing.
33880661	11	72	with	scaffolds	1794:1802	arg1	moieties					1819:1826	bioactive moieties	1809:1826	bioactive moieties	1809:1826	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	8	73	theme	aerosol	1367:1373	arg1	treatment					1375:1383	aerosol treatment	1367:1383	aerosol treatment	1367:1383	Aerosol deposited scaffolds showed minimum clotting time of 20 ± 3 s and bleeding time of 38 ± 4 s, which was significantly lower compared to the scaffolds without aerosol treatment.
33880661	5	74	from	RU	957:958	arg1	concentration					923:935	blood cell concentration	912:935	blood cell concentration from 480.8 to 886.4 RU for erythrocytes	912:975	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	5	74	from	RU	957:958	arg1	increase					900:907	the increase	896:907	the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes	896:975	A detailed investigation by surface plasmon resonance confirmed higher binding affinity of collagen toward the human blood platelets and erythrocytes in comparison to chitosan and was found to increase with the increase in blood cell concentration from 480.8 to 886.4 RU for erythrocytes.
33880661	9	75	dep	deposited	1394:1402	arg1	Aerosol					1386:1392	Aerosol	1386:1392	Aerosol	1386:1392	Aerosol deposited composite scaffolds with 2:1 concentration of chitosan/collagen showed complete wound contraction by day 14, while 50% was observed in case of the control group.
33880661	3	76	theme	differential	399:410	arg1	calorimetry					421:431	differential scanning calorimetry	399:431	differential scanning calorimetry	399:431	Composite scaffolds were characterized using differential scanning calorimetry, thermogravimetric analysis, and Fourier-transform infrared spectrophotometer to ascertain the aerosol deposition and stability.
33880661	10	77	contain	had	1605:1607	arg2	role					1619:1622	a crucial role	1609:1622	a crucial role	1609:1622	In vivo studies revealed that chitosan had a crucial role in the inflammatory phase, while collagen played an important role in the proliferation and maturation phase.
33880661	10	77	contain	had	1605:1607	arg1	chitosan					1596:1603	chitosan	1596:1603	chitosan	1596:1603	In vivo studies revealed that chitosan had a crucial role in the inflammatory phase, while collagen played an important role in the proliferation and maturation phase.
33880661	4	78	theme	electron	571:578	arg1	microscope					580:589	Scanning electron microscope	562:589	Scanning electron microscope	562:589	Scanning electron microscope showed multilayered porosity with pore size of ~30 μm and mushroom-like fibril growth of aerosol.
33880661	3	79	theme	thermogravimetric	434:450	arg1	analysis					452:459	thermogravimetric analysis	434:459	thermogravimetric analysis	434:459	Composite scaffolds were characterized using differential scanning calorimetry, thermogravimetric analysis, and Fourier-transform infrared spectrophotometer to ascertain the aerosol deposition and stability.
33880661	4	80	theme	μm	642:643	arg1	size					630:633	pore size	625:633	pore size of ~30 μm	625:643	Scanning electron microscope showed multilayered porosity with pore size of ~30 μm and mushroom-like fibril growth of aerosol.
33880661	4	80	theme	μm	642:643	arg1	growth					670:675	mushroom-like fibril growth	649:675	mushroom-like fibril growth	649:675	Scanning electron microscope showed multilayered porosity with pore size of ~30 μm and mushroom-like fibril growth of aerosol.
33880661	0	81	theme	Bioactive	33:41	arg1	Composite					43:51	Three-Dimensional Bioactive Composite	15:51	Three-Dimensional Bioactive Composite	15:51	Fabrication of Three-Dimensional Bioactive Composite Scaffolds for Hemostasis and Wound Healing.
33880661	9	82	theme	composite	1404:1412	arg1	scaffolds					1414:1422	Aerosol deposited composite scaffolds	1386:1422	Aerosol deposited composite scaffolds with 2:1 concentration of chitosan/collagen	1386:1466	Aerosol deposited composite scaffolds with 2:1 concentration of chitosan/collagen showed complete wound contraction by day 14, while 50% was observed in case of the control group.
33880661	1	83	theme	3D	112:113	arg1	scaffolds					125:133	3D composite scaffolds	112:133	3D composite scaffolds	112:133	Fabrication of 3D composite scaffolds was carried out by lyophilization of variable concentrations of collagen and chitosan gel solutions.
33880661	4	84	theme	mushroom-like	649:661	arg1	growth					670:675	mushroom-like fibril growth	649:675	mushroom-like fibril growth	649:675	Scanning electron microscope showed multilayered porosity with pore size of ~30 μm and mushroom-like fibril growth of aerosol.
33880661	3	85	theme	Fourier-transform	466:482	arg1	spectrophotometer					493:509	Fourier-transform infrared spectrophotometer	466:509	Fourier-transform infrared spectrophotometer	466:509	Composite scaffolds were characterized using differential scanning calorimetry, thermogravimetric analysis, and Fourier-transform infrared spectrophotometer to ascertain the aerosol deposition and stability.
33880661	4	86	theme	pore	625:628	arg1	size					630:633	pore size	625:633	pore size of ~30 μm	625:643	Scanning electron microscope showed multilayered porosity with pore size of ~30 μm and mushroom-like fibril growth of aerosol.
33880661	3	87	theme	aerosol	528:534	arg1	deposition					536:545	the aerosol deposition	524:545	the aerosol deposition	524:545	Composite scaffolds were characterized using differential scanning calorimetry, thermogravimetric analysis, and Fourier-transform infrared spectrophotometer to ascertain the aerosol deposition and stability.
33880661	11	88	theme	fabricated	1770:1779	arg1	scaffolds					1794:1802	the fabricated 3D composite scaffolds	1766:1802	the fabricated 3D composite scaffolds with bioactive moieties	1766:1826	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	11	88	theme	fabricated	1770:1779	arg1	candidate					1847:1855	a potential candidate	1835:1855	a potential candidate for enhanced hemostasis and wound healing applications	1835:1910	The present study suggests that the fabricated 3D composite scaffolds with bioactive moieties may be a potential candidate for enhanced hemostasis and wound healing applications.
33880661	9	89	theme	chitosan/collagen	1450:1466	arg1	concentration					1433:1445	2:1 concentration	1429:1445	2:1 concentration of chitosan/collagen	1429:1466	Aerosol deposited composite scaffolds with 2:1 concentration of chitosan/collagen showed complete wound contraction by day 14, while 50% was observed in case of the control group.
33880661	8	90	theme	deposited	1211:1219	arg1	scaffolds					1221:1229	Aerosol deposited scaffolds	1203:1229	Aerosol deposited scaffolds	1203:1229	Aerosol deposited scaffolds showed minimum clotting time of 20 ± 3 s and bleeding time of 38 ± 4 s, which was significantly lower compared to the scaffolds without aerosol treatment.
33880661	10	91	theme	In	1566:1567	arg1	studies					1574:1580	In vivo studies	1566:1580	In vivo studies	1566:1580	In vivo studies revealed that chitosan had a crucial role in the inflammatory phase, while collagen played an important role in the proliferation and maturation phase.
33880661	9	92	theme	complete	1475:1482	arg1	contraction					1490:1500	complete wound contraction	1475:1500	complete wound contraction	1475:1500	Aerosol deposited composite scaffolds with 2:1 concentration of chitosan/collagen showed complete wound contraction by day 14, while 50% was observed in case of the control group.
32179115	8	0	theme	kinetic	1081:1087	arg1	adsorption					1033:1042	The dye adsorption	1025:1042	The dye adsorption	1025:1042	The dye adsorption was found to be a pseudo-first order kinetic process.
32179115	8	0	theme	kinetic	1081:1087	arg1	process					1089:1095	a pseudo-first order kinetic process	1060:1095	a pseudo-first order kinetic process	1060:1095	The dye adsorption was found to be a pseudo-first order kinetic process.
32179115	9	1	theme	formation	1236:1244	arg1	possibility					1210:1220	possibility	1210:1220	possibility of multilayer formation	1210:1244	The adsorption data is found to best fit with Freundlich isotherm model indicating heterogeneous adsorption and possibility of multilayer formation.
32179115	9	1	theme	formation	1236:1244	arg1	adsorption					1195:1204	heterogeneous adsorption	1181:1204	heterogeneous adsorption	1181:1204	The adsorption data is found to best fit with Freundlich isotherm model indicating heterogeneous adsorption and possibility of multilayer formation.
32179115	9	2	theme	adsorption	1102:1111	arg1	data					1113:1116	The adsorption data	1098:1116	The adsorption data	1098:1116	The adsorption data is found to best fit with Freundlich isotherm model indicating heterogeneous adsorption and possibility of multilayer formation.
32179115	10	3	theme	ΔG	1265:1266	arg1	value					1256:1260	Negative value	1247:1260	Negative value of ΔG	1247:1266	Negative value of ΔG indicated the spontaneous nature of adsorption process at the temperatures under study.
32179115	8	4	theme	order	1075:1079	arg1	adsorption					1033:1042	The dye adsorption	1025:1042	The dye adsorption	1025:1042	The dye adsorption was found to be a pseudo-first order kinetic process.
32179115	8	4	theme	order	1075:1079	arg1	process					1089:1095	a pseudo-first order kinetic process	1060:1095	a pseudo-first order kinetic process	1060:1095	The dye adsorption was found to be a pseudo-first order kinetic process.
32179115	5	5	theme	17.28 g/g	676:684	arg1	minimum					665:671	minimum	665:671	minimum of 17.28 g/g	665:684	The maximum swelling of 42.23 g/g was observed at pH 7.0 and minimum of 17.28 g/g was noticed at pH 9.2.
32179115	11	6	theme	dyes	1435:1438	arg1	%					1417:1417	about 70%	1409:1417	about 70% of the adsorbed dyes	1409:1438	The reusability studies indicated that desorption of about 70% of the adsorbed dyes can be achieved after two consecutive cycles.
32179115	11	6	theme	dyes	1435:1438	arg1	dyes					1435:1438	the adsorbed dyes	1422:1438	the adsorbed dyes	1422:1438	The reusability studies indicated that desorption of about 70% of the adsorbed dyes can be achieved after two consecutive cycles.
32179115	1	7	theme	modified	272:279	arg1	gum					288:290	modified karaya gum	272:290	modified karaya gum	272:290	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT) has been synthesised by microwave assisted free radical polymerisation using modified karaya gum and clay mineral and was characterised by various techniques.
32179115	5	8	theme	42.23 g/g	628:636	arg1	swelling					616:623	The maximum swelling	604:623	The maximum swelling of 42.23 g/g	604:636	The maximum swelling of 42.23 g/g was observed at pH 7.0 and minimum of 17.28 g/g was noticed at pH 9.2.
32179115	10	9	theme	adsorption	1304:1313	arg1	process					1315:1321	adsorption process	1304:1321	adsorption process	1304:1321	Negative value of ΔG indicated the spontaneous nature of adsorption process at the temperatures under study.
32179115	1	10	theme	karaya	281:286	arg1	gum					288:290	modified karaya gum	272:290	modified karaya gum	272:290	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT) has been synthesised by microwave assisted free radical polymerisation using modified karaya gum and clay mineral and was characterised by various techniques.
32179115	10	11	theme	Negative	1247:1254	arg1	value					1256:1260	Negative value	1247:1260	Negative value of ΔG	1247:1266	Negative value of ΔG indicated the spontaneous nature of adsorption process at the temperatures under study.
32179115	0	12	theme	adsorption	115:124	arg1	studies					126:132	dye adsorption studies	111:132	dye adsorption studies	111:132	Microwave assisted synthesis of karaya gum based montmorillonite nanocomposite: Characterisation, swelling and dye adsorption studies.
32179115	11	13	theme	consecutive	1466:1476	arg1	cycles					1478:1483	two consecutive cycles	1462:1483	two consecutive cycles	1462:1483	The reusability studies indicated that desorption of about 70% of the adsorbed dyes can be achieved after two consecutive cycles.
32179115	7	14	theme	blue	889:892	arg1	methylene					879:887	methylene blue	879:892	methylene blue (MB)	879:897	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	14	theme	blue	889:892	arg1	MB					895:896	MB	895:896	MB	895:896	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	14	theme	blue	889:892	arg1	dyes					873:876	the chosen cationic dyes	853:876	the chosen cationic dyes	853:876	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	0	15	theme	dye	111:113	arg1	studies					126:132	dye adsorption studies	111:132	dye adsorption studies	111:132	Microwave assisted synthesis of karaya gum based montmorillonite nanocomposite: Characterisation, swelling and dye adsorption studies.
32179115	7	16	theme	crystal	921:927	arg1	CV					937:938	CV	937:938	CV	937:938	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	16	theme	crystal	921:927	arg1	violet					929:934	crystal violet	921:934	crystal violet (CV)	921:939	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	16	theme	crystal	921:927	arg1	dyes					873:876	the chosen cationic dyes	853:876	the chosen cationic dyes	853:876	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	2	17	theme	prior	458:462	arg1	chloride					449:456	(2-methacryloyloxy ethyl) trimethyl ammonium chloride	404:456	(2-methacryloyloxy ethyl) trimethyl ammonium chloride prior to making the clay composite	404:491	The karaya gum has been modified by grafting with (2-methacryloyloxy ethyl) trimethyl ammonium chloride prior to making the clay composite.
32179115	6	18	theme	transport	719:727	arg1	Fickian					743:749	Fickian	743:749	Fickian in nature	743:759	The water transport mechanism was Fickian in nature and followed second order kinetic model.
32179115	6	18	theme	transport	719:727	arg1	mechanism					729:737	The water transport mechanism	709:737	The water transport mechanism	709:737	The water transport mechanism was Fickian in nature and followed second order kinetic model.
32179115	0	19	theme	assisted	10:17	arg1	synthesis					19:27	Microwave assisted synthesis	0:27	Microwave assisted synthesis of karaya gum based	0:47	Microwave assisted synthesis of karaya gum based montmorillonite nanocomposite: Characterisation, swelling and dye adsorption studies.
32179115	6	20	theme	water	713:717	arg1	Fickian					743:749	Fickian	743:749	Fickian in nature	743:759	The water transport mechanism was Fickian in nature and followed second order kinetic model.
32179115	6	20	theme	water	713:717	arg1	mechanism					729:737	The water transport mechanism	709:737	The water transport mechanism	709:737	The water transport mechanism was Fickian in nature and followed second order kinetic model.
32179115	0	21	theme	Microwave	0:8	arg1	synthesis					19:27	Microwave assisted synthesis	0:27	Microwave assisted synthesis of karaya gum based	0:47	Microwave assisted synthesis of karaya gum based montmorillonite nanocomposite: Characterisation, swelling and dye adsorption studies.
32179115	4	22	theme	responsive	573:582	arg1	behaviour					593:601	pH responsive swelling behaviour	570:601	pH responsive swelling behaviour	570:601	The nanocomposite exhibited pH responsive swelling behaviour.
32179115	6	23	from	Fickian	743:749	arg1	nature					754:759	nature	754:759	nature	754:759	The water transport mechanism was Fickian in nature and followed second order kinetic model.
32179115	5	24	theme	maximum	608:614	arg1	swelling					616:623	The maximum swelling	604:623	The maximum swelling of 42.23 g/g	604:636	The maximum swelling of 42.23 g/g was observed at pH 7.0 and minimum of 17.28 g/g was noticed at pH 9.2.
32179115	7	25	theme	chosen	857:862	arg1	toluidine					900:908	toluidine blue	900:913	toluidine blue (TB)	900:918	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	25	theme	chosen	857:862	arg1	violet					929:934	crystal violet	921:934	crystal violet (CV)	921:939	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	25	theme	chosen	857:862	arg1	methylene					879:887	methylene blue	879:892	methylene blue (MB)	879:897	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	25	theme	chosen	857:862	arg1	B					951:951	azure B	945:951	azure B (AB)	945:956	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	25	theme	chosen	857:862	arg1	dyes					873:876	the chosen cationic dyes	853:876	the chosen cationic dyes	853:876	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	5	26	located	observed	642:649	arg2	swelling					616:623	The maximum swelling	604:623	The maximum swelling of 42.23 g/g	604:636	The maximum swelling of 42.23 g/g was observed at pH 7.0 and minimum of 17.28 g/g was noticed at pH 9.2.
32179115	5	26	located	observed	642:649	arg1	pH 7.0					654:659	pH 7.0	654:659	pH 7.0	654:659	The maximum swelling of 42.23 g/g was observed at pH 7.0 and minimum of 17.28 g/g was noticed at pH 9.2.
32179115	7	27	theme	nanocomposite	835:847	arg1	capacities					817:826	The adsorption capacities	802:826	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB)	802:956	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	9	28	theme	Freundlich	1144:1153	arg1	model					1164:1168	Freundlich isotherm model	1144:1168	Freundlich isotherm model	1144:1168	The adsorption data is found to best fit with Freundlich isotherm model indicating heterogeneous adsorption and possibility of multilayer formation.
32179115	7	29	theme	cationic	864:871	arg1	toluidine					900:908	toluidine blue	900:913	toluidine blue (TB)	900:918	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	29	theme	cationic	864:871	arg1	violet					929:934	crystal violet	921:934	crystal violet (CV)	921:939	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	29	theme	cationic	864:871	arg1	methylene					879:887	methylene blue	879:892	methylene blue (MB)	879:897	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	29	theme	cationic	864:871	arg1	B					951:951	azure B	945:951	azure B (AB)	945:956	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	29	theme	cationic	864:871	arg1	dyes					873:876	the chosen cationic dyes	853:876	the chosen cationic dyes	853:876	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	2	30	theme	trimethyl	430:438	arg1	chloride					449:456	(2-methacryloyloxy ethyl) trimethyl ammonium chloride	404:456	(2-methacryloyloxy ethyl) trimethyl ammonium chloride prior to making the clay composite	404:491	The karaya gum has been modified by grafting with (2-methacryloyloxy ethyl) trimethyl ammonium chloride prior to making the clay composite.
32179115	2	31	theme	ammonium	440:447	arg1	chloride					449:456	(2-methacryloyloxy ethyl) trimethyl ammonium chloride	404:456	(2-methacryloyloxy ethyl) trimethyl ammonium chloride prior to making the clay composite	404:491	The karaya gum has been modified by grafting with (2-methacryloyloxy ethyl) trimethyl ammonium chloride prior to making the clay composite.
32179115	10	32	theme	spontaneous	1282:1292	arg1	nature					1294:1299	the spontaneous nature	1278:1299	the spontaneous nature of adsorption process	1278:1321	Negative value of ΔG indicated the spontaneous nature of adsorption process at the temperatures under study.
32179115	9	33	theme	isotherm	1155:1162	arg1	model					1164:1168	Freundlich isotherm model	1144:1168	Freundlich isotherm model	1144:1168	The adsorption data is found to best fit with Freundlich isotherm model indicating heterogeneous adsorption and possibility of multilayer formation.
32179115	3	34	theme	clay	526:529	arg1	Montmorillonite					494:508	Montmorillonite	494:508	Montmorillonite	494:508	Montmorillonite was used as the clay component.
32179115	3	34	theme	clay	526:529	arg1	component					531:539	the clay component	522:539	the clay component	522:539	Montmorillonite was used as the clay component.
32179115	0	35	theme	gum	39:41	arg1	based					43:47	karaya gum based	32:47	karaya gum based	32:47	Microwave assisted synthesis of karaya gum based montmorillonite nanocomposite: Characterisation, swelling and dye adsorption studies.
32179115	4	36	theme	swelling	584:591	arg1	behaviour					593:601	pH responsive swelling behaviour	570:601	pH responsive swelling behaviour	570:601	The nanocomposite exhibited pH responsive swelling behaviour.
32179115	11	37	theme	%	1417:1417	arg1	desorption					1395:1404	desorption	1395:1404	desorption of about 70% of the adsorbed dyes	1395:1438	The reusability studies indicated that desorption of about 70% of the adsorbed dyes can be achieved after two consecutive cycles.
32179115	2	38	theme	ethyl	423:427	arg1	chloride					449:456	(2-methacryloyloxy ethyl) trimethyl ammonium chloride	404:456	(2-methacryloyloxy ethyl) trimethyl ammonium chloride prior to making the clay composite	404:491	The karaya gum has been modified by grafting with (2-methacryloyloxy ethyl) trimethyl ammonium chloride prior to making the clay composite.
32179115	2	39	theme	clay	478:481	arg1	composite					483:491	the clay composite	474:491	the clay composite	474:491	The karaya gum has been modified by grafting with (2-methacryloyloxy ethyl) trimethyl ammonium chloride prior to making the clay composite.
32179115	0	40	theme	karaya	32:37	arg1	based					43:47	karaya gum based	32:47	karaya gum based	32:47	Microwave assisted synthesis of karaya gum based montmorillonite nanocomposite: Characterisation, swelling and dye adsorption studies.
32179115	11	41	theme	reusability	1360:1370	arg1	studies					1372:1378	The reusability studies	1356:1378	The reusability studies	1356:1378	The reusability studies indicated that desorption of about 70% of the adsorbed dyes can be achieved after two consecutive cycles.
32179115	6	42	theme	kinetic	787:793	arg1	model					795:799	second order kinetic model	774:799	second order kinetic model	774:799	The water transport mechanism was Fickian in nature and followed second order kinetic model.
32179115	1	43	theme	microwave	219:227	arg1	polymerisation					251:264	microwave assisted free radical polymerisation	219:264	microwave assisted free radical polymerisation using modified karaya gum and clay mineral	219:307	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT) has been synthesised by microwave assisted free radical polymerisation using modified karaya gum and clay mineral and was characterised by various techniques.
32179115	7	44	theme	adsorption	806:815	arg1	capacities					817:826	The adsorption capacities	802:826	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB)	802:956	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	9	45	theme	heterogeneous	1181:1193	arg1	adsorption					1195:1204	heterogeneous adsorption	1181:1204	heterogeneous adsorption	1181:1204	The adsorption data is found to best fit with Freundlich isotherm model indicating heterogeneous adsorption and possibility of multilayer formation.
32179115	3	46	used	used	514:517	arg2	component					531:539	the clay component	522:539	the clay component	522:539	Montmorillonite was used as the clay component.
32179115	3	46	used	used	514:517	arg2	Montmorillonite					494:508	Montmorillonite	494:508	Montmorillonite	494:508	Montmorillonite was used as the clay component.
32179115	6	47	theme	order	781:785	arg1	model					795:799	second order kinetic model	774:799	second order kinetic model	774:799	The water transport mechanism was Fickian in nature and followed second order kinetic model.
32179115	2	48	theme	karaya	358:363	arg1	gum					365:367	The karaya gum	354:367	The karaya gum	354:367	The karaya gum has been modified by grafting with (2-methacryloyloxy ethyl) trimethyl ammonium chloride prior to making the clay composite.
32179115	0	49	theme	based	43:47	arg1	synthesis					19:27	Microwave assisted synthesis	0:27	Microwave assisted synthesis of karaya gum based	0:47	Microwave assisted synthesis of karaya gum based montmorillonite nanocomposite: Characterisation, swelling and dye adsorption studies.
32179115	6	50	theme	second	774:779	arg1	model					795:799	second order kinetic model	774:799	second order kinetic model	774:799	The water transport mechanism was Fickian in nature and followed second order kinetic model.
32179115	1	51	theme	various	334:340	arg1	techniques					342:351	various techniques	334:351	various techniques	334:351	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT) has been synthesised by microwave assisted free radical polymerisation using modified karaya gum and clay mineral and was characterised by various techniques.
32179115	10	52	theme	process	1315:1321	arg1	nature					1294:1299	the spontaneous nature	1278:1299	the spontaneous nature of adsorption process	1278:1321	Negative value of ΔG indicated the spontaneous nature of adsorption process at the temperatures under study.
32179115	1	53	theme	assisted	229:236	arg1	radical					243:249	assisted free radical	229:249	microwave assisted free radical polymerisation using modified karaya gum and clay mineral	219:307	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT) has been synthesised by microwave assisted free radical polymerisation using modified karaya gum and clay mineral and was characterised by various techniques.
32179115	1	54	theme	polymer-clay	137:148	arg1	material					167:174	A polymer-clay hybrid composite material	135:174	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT)	135:193	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT) has been synthesised by microwave assisted free radical polymerisation using modified karaya gum and clay mineral and was characterised by various techniques.
32179115	1	54	theme	polymer-clay	137:148	arg1	KG-g-PMETAC/MMT					178:192	KG-g-PMETAC/MMT	178:192	KG-g-PMETAC/MMT	178:192	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT) has been synthesised by microwave assisted free radical polymerisation using modified karaya gum and clay mineral and was characterised by various techniques.
32179115	11	55	theme	adsorbed	1426:1433	arg1	dyes					1435:1438	the adsorbed dyes	1422:1438	the adsorbed dyes	1422:1438	The reusability studies indicated that desorption of about 70% of the adsorbed dyes can be achieved after two consecutive cycles.
32179115	1	56	theme	free	238:241	arg1	radical					243:249	assisted free radical	229:249	microwave assisted free radical polymerisation using modified karaya gum and clay mineral	219:307	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT) has been synthesised by microwave assisted free radical polymerisation using modified karaya gum and clay mineral and was characterised by various techniques.
32179115	8	57	theme	pseudo-first	1062:1073	arg1	adsorption					1033:1042	The dye adsorption	1025:1042	The dye adsorption	1025:1042	The dye adsorption was found to be a pseudo-first order kinetic process.
32179115	8	57	theme	pseudo-first	1062:1073	arg1	process					1089:1095	a pseudo-first order kinetic process	1060:1095	a pseudo-first order kinetic process	1060:1095	The dye adsorption was found to be a pseudo-first order kinetic process.
32179115	2	58	theme	2-methacryloyloxy	405:421	arg1	chloride					449:456	(2-methacryloyloxy ethyl) trimethyl ammonium chloride	404:456	(2-methacryloyloxy ethyl) trimethyl ammonium chloride prior to making the clay composite	404:491	The karaya gum has been modified by grafting with (2-methacryloyloxy ethyl) trimethyl ammonium chloride prior to making the clay composite.
32179115	1	59	theme	hybrid	150:155	arg1	material					167:174	A polymer-clay hybrid composite material	135:174	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT)	135:193	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT) has been synthesised by microwave assisted free radical polymerisation using modified karaya gum and clay mineral and was characterised by various techniques.
32179115	1	59	theme	hybrid	150:155	arg1	KG-g-PMETAC/MMT					178:192	KG-g-PMETAC/MMT	178:192	KG-g-PMETAC/MMT	178:192	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT) has been synthesised by microwave assisted free radical polymerisation using modified karaya gum and clay mineral and was characterised by various techniques.
32179115	7	60	theme	blue	910:913	arg1	dyes					873:876	the chosen cationic dyes	853:876	the chosen cationic dyes	853:876	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	60	theme	blue	910:913	arg1	toluidine					900:908	toluidine blue	900:913	toluidine blue (TB)	900:918	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	60	theme	blue	910:913	arg1	TB					916:917	TB	916:917	TB	916:917	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	1	61	theme	radical	243:249	arg1	polymerisation					251:264	microwave assisted free radical polymerisation	219:264	microwave assisted free radical polymerisation using modified karaya gum and clay mineral	219:307	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT) has been synthesised by microwave assisted free radical polymerisation using modified karaya gum and clay mineral and was characterised by various techniques.
32179115	9	62	theme	multilayer	1225:1234	arg1	formation					1236:1244	multilayer formation	1225:1244	multilayer formation	1225:1244	The adsorption data is found to best fit with Freundlich isotherm model indicating heterogeneous adsorption and possibility of multilayer formation.
32179115	7	63	theme	azure	945:949	arg1	AB					954:955	AB	954:955	AB	954:955	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	63	theme	azure	945:949	arg1	B					951:951	azure B	945:951	azure B (AB)	945:956	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	7	63	theme	azure	945:949	arg1	dyes					873:876	the chosen cationic dyes	853:876	the chosen cationic dyes	853:876	The adsorption capacities of the nanocomposite for the chosen cationic dyes, methylene blue (MB), toluidine blue (TB), crystal violet (CV) and azure B (AB) were found to 155.85, 149.64, 137.77 and 128.78 mg/g respectively.
32179115	1	64	theme	composite	157:165	arg1	material					167:174	A polymer-clay hybrid composite material	135:174	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT)	135:193	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT) has been synthesised by microwave assisted free radical polymerisation using modified karaya gum and clay mineral and was characterised by various techniques.
32179115	1	64	theme	composite	157:165	arg1	KG-g-PMETAC/MMT					178:192	KG-g-PMETAC/MMT	178:192	KG-g-PMETAC/MMT	178:192	A polymer-clay hybrid composite material, (KG-g-PMETAC/MMT) has been synthesised by microwave assisted free radical polymerisation using modified karaya gum and clay mineral and was characterised by various techniques.
32179115	8	65	theme	dye	1029:1031	arg1	adsorption					1033:1042	The dye adsorption	1025:1042	The dye adsorption	1025:1042	The dye adsorption was found to be a pseudo-first order kinetic process.
32179115	8	65	theme	dye	1029:1031	arg1	process					1089:1095	a pseudo-first order kinetic process	1060:1095	a pseudo-first order kinetic process	1060:1095	The dye adsorption was found to be a pseudo-first order kinetic process.
33383133	11	0	theme	inhibition	2015:2024	arg1	rate					2026:2029	a tumor inhibition rate	2007:2029	a tumor inhibition rate of 71.6%	2007:2038	Correspondingly, the DGL-GA-CDA-DOX-HA displayed the preferable antitumor efficiency to other experimental groups in H22 tumor-bearing mice, with a tumor inhibition rate of 71.6%.
33383133	1	1	theme	receptor-mediated	260:276	arg1	endocytosis					278:288	receptor-mediated endocytosis	260:288	receptor-mediated endocytosis	260:288	In the present study, the three functions, including enhanced permeability and retention (EPR) effect, deep penetration within tumor, and receptor-mediated endocytosis, were integrated into a single platform in order to improve antitumor efficiency.
33383133	9	2	theme	multicellular	1617:1629	arg1	spheroids					1637:1645	vitro multicellular tumor spheroids	1611:1645	vitro multicellular tumor spheroids	1611:1645	The study showed that the penetrability of DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids were always better than that of DGL-GA-CDA-DOX-HA nanoparticles untreated by HAase.
33383133	7	3	theme	drug	1330:1333	arg1	release					1335:1341	drug release	1330:1341	drug release	1330:1341	However, when the nanoparticles were exposed to a medium without HAase at pH 5.0, or a neutral medium containing HAase, drug release slowed down.
33383133	1	4	theme	permeability	184:195	arg1	effect					217:222	enhanced permeability and retention (EPR) effect	175:222	enhanced permeability and retention (EPR) effect	175:222	In the present study, the three functions, including enhanced permeability and retention (EPR) effect, deep penetration within tumor, and receptor-mediated endocytosis, were integrated into a single platform in order to improve antitumor efficiency.
33383133	4	5	theme	DLS	876:878	arg1	results					857:863	the results	853:863	the results of TEM and DLS	853:878	According to the results of TEM and DLS, the DGL-GA-CDA-DOX-HA nanoparticles could be rapidly degraded with a size shrink from 182.5 nm to 47.7 nm by hyaluronidase (HAase) added in the medium.
33383133	3	6	theme	electron	602:609	arg1	TEM					623:625	TEM	623:625	TEM	623:625	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	6	theme	electron	602:609	arg1	microscope					611:620	The transmission electron microscope	585:620	The transmission electron microscope (TEM)	585:626	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	1	7	theme	retention	201:209	arg1	effect					217:222	enhanced permeability and retention (EPR) effect	175:222	enhanced permeability and retention (EPR) effect	175:222	In the present study, the three functions, including enhanced permeability and retention (EPR) effect, deep penetration within tumor, and receptor-mediated endocytosis, were integrated into a single platform in order to improve antitumor efficiency.
33383133	11	8	theme	experimental	1955:1966	arg1	groups					1968:1973	other experimental groups	1949:1973	other experimental groups	1949:1973	Correspondingly, the DGL-GA-CDA-DOX-HA displayed the preferable antitumor efficiency to other experimental groups in H22 tumor-bearing mice, with a tumor inhibition rate of 71.6%.
33383133	5	9	theme	loading	1037:1043	arg1	DOX					1055:1057	DOX	1055:1057	DOX	1055:1057	The loading amount of DOX reached 252.03 ± 36.38 mg/g for DGL-GA-CDA-DOX nanoparticles.
33383133	5	9	theme	loading	1037:1043	arg1	amount					1045:1050	The loading amount	1033:1050	The loading amount of DOX	1033:1057	The loading amount of DOX reached 252.03 ± 36.38 mg/g for DGL-GA-CDA-DOX nanoparticles.
33383133	10	10	dep	in	1743:1744	arg1	vivo					1746:1749	vivo	1746:1749	vivo	1746:1749	The imaging in vivo and ex vivo exhibited that DGL-GA-CDA-DOX-HA nanoparticles could preferentially accumulate in the tumor site.
33383133	3	11	theme	zeta	745:748	arg1	potentials					750:759	zeta potentials	745:759	zeta potentials	745:759	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	10	12	theme	ex	1755:1756	arg1	imaging					1735:1741	The imaging	1731:1741	The imaging in vivo and ex vivo	1731:1761	The imaging in vivo and ex vivo exhibited that DGL-GA-CDA-DOX-HA nanoparticles could preferentially accumulate in the tumor site.
33383133	9	13	from	HAase	1602:1606	arg1	spheroids					1637:1645	vitro multicellular tumor spheroids	1611:1645	vitro multicellular tumor spheroids	1611:1645	The study showed that the penetrability of DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids were always better than that of DGL-GA-CDA-DOX-HA nanoparticles untreated by HAase.
33383133	4	14	theme	DGL-GA-CDA-DOX-HA	885:901	arg1	nanoparticles					903:915	the DGL-GA-CDA-DOX-HA nanoparticles	881:915	the DGL-GA-CDA-DOX-HA nanoparticles	881:915	According to the results of TEM and DLS, the DGL-GA-CDA-DOX-HA nanoparticles could be rapidly degraded with a size shrink from 182.5 nm to 47.7 nm by hyaluronidase (HAase) added in the medium.
33383133	8	15	theme	GA	1376:1377	arg1	modification					1360:1371	The modification	1356:1371	The modification of GA on nanoparticles	1356:1394	The modification of GA on nanoparticles significantly enhanced their affinity and cytotoxicity to hepatocellular carcinoma HepG2 cells.
33383133	8	16	from	modification	1360:1371	arg1	nanoparticles					1382:1394	nanoparticles	1382:1394	nanoparticles	1382:1394	The modification of GA on nanoparticles significantly enhanced their affinity and cytotoxicity to hepatocellular carcinoma HepG2 cells.
33383133	5	17	theme	±	1074:1074	arg1	mg/g					1082:1085	252.03 ± 36.38 mg/g	1067:1085	252.03 ± 36.38 mg/g for DGL-GA-CDA-DOX nanoparticles	1067:1118	The loading amount of DOX reached 252.03 ± 36.38 mg/g for DGL-GA-CDA-DOX nanoparticles.
33383133	10	18	theme	DGL-GA-CDA-DOX-HA	1778:1794	arg1	nanoparticles					1796:1808	DGL-GA-CDA-DOX-HA nanoparticles	1778:1808	DGL-GA-CDA-DOX-HA nanoparticles	1778:1808	The imaging in vivo and ex vivo exhibited that DGL-GA-CDA-DOX-HA nanoparticles could preferentially accumulate in the tumor site.
33383133	4	19	theme	TEM	868:870	arg1	results					857:863	the results	853:863	the results of TEM and DLS	853:878	According to the results of TEM and DLS, the DGL-GA-CDA-DOX-HA nanoparticles could be rapidly degraded with a size shrink from 182.5 nm to 47.7 nm by hyaluronidase (HAase) added in the medium.
33383133	1	20	theme	antitumor	350:358	arg1	efficiency					360:369	antitumor efficiency	350:369	antitumor efficiency	350:369	In the present study, the three functions, including enhanced permeability and retention (EPR) effect, deep penetration within tumor, and receptor-mediated endocytosis, were integrated into a single platform in order to improve antitumor efficiency.
33383133	4	21	theme	size	950:953	arg1	shrink					955:960	a size shrink	948:960	a size shrink from 182.5 nm to 47.7 nm	948:985	According to the results of TEM and DLS, the DGL-GA-CDA-DOX-HA nanoparticles could be rapidly degraded with a size shrink from 182.5 nm to 47.7 nm by hyaluronidase (HAase) added in the medium.
33383133	2	22	theme	dendrigraft	394:404	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	22	theme	dendrigraft	394:404	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	23	theme	hyaluronic	488:497	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	23	theme	hyaluronic	488:497	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	7	24	from	pH	1284:1285	arg1	medium					1305:1310	a neutral medium	1295:1310	a neutral medium containing HAase	1295:1327	However, when the nanoparticles were exposed to a medium without HAase at pH 5.0, or a neutral medium containing HAase, drug release slowed down.
33383133	7	24	from	pH	1284:1285	arg1	medium					1260:1265	a medium	1258:1265	a medium without HAase at pH 5.0	1258:1289	However, when the nanoparticles were exposed to a medium without HAase at pH 5.0, or a neutral medium containing HAase, drug release slowed down.
33383133	2	25	theme	anhydride	465:473	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	25	theme	anhydride	465:473	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	8	26	theme	hepatocellular	1454:1467	arg1	cells					1485:1489	hepatocellular carcinoma HepG2 cells	1454:1489	hepatocellular carcinoma HepG2 cells	1454:1489	The modification of GA on nanoparticles significantly enhanced their affinity and cytotoxicity to hepatocellular carcinoma HepG2 cells.
33383133	11	27	theme	antitumor	1925:1933	arg1	efficiency					1935:1944	the preferable antitumor efficiency	1910:1944	the preferable antitumor efficiency to other experimental groups in H22 tumor-bearing mice	1910:1999	Correspondingly, the DGL-GA-CDA-DOX-HA displayed the preferable antitumor efficiency to other experimental groups in H22 tumor-bearing mice, with a tumor inhibition rate of 71.6%.
33383133	7	28	contain	containing	1312:1321	arg1	medium					1305:1310	a neutral medium	1295:1310	a neutral medium containing HAase	1295:1327	However, when the nanoparticles were exposed to a medium without HAase at pH 5.0, or a neutral medium containing HAase, drug release slowed down.
33383133	7	28	contain	containing	1312:1321	arg2	HAase					1323:1327	HAase	1323:1327	HAase	1323:1327	However, when the nanoparticles were exposed to a medium without HAase at pH 5.0, or a neutral medium containing HAase, drug release slowed down.
33383133	2	29	theme	cyclohexane	440:450	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	29	theme	cyclohexane	440:450	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	8	30	theme	HepG2	1479:1483	arg1	cells					1485:1489	hepatocellular carcinoma HepG2 cells	1454:1489	hepatocellular carcinoma HepG2 cells	1454:1489	The modification of GA on nanoparticles significantly enhanced their affinity and cytotoxicity to hepatocellular carcinoma HepG2 cells.
33383133	2	31	theme	acid	435:438	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	31	theme	acid	435:438	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	0	32	theme	protein	20:26	arg1	Cα-recognizable					35:49	protein kinase Cα-recognizable	20:49	protein kinase Cα-recognizable	20:49	Size-shrinkable and protein kinase Cα-recognizable nanoparticles for deep tumor penetration and cellular internalization.
33383133	4	33	theme	47.7	979:982	arg1	nm					973:974	nm	973:974	nm	973:974	According to the results of TEM and DLS, the DGL-GA-CDA-DOX-HA nanoparticles could be rapidly degraded with a size shrink from 182.5 nm to 47.7 nm by hyaluronidase (HAase) added in the medium.
33383133	2	34	theme	@	419:419	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	34	theme	@	419:419	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	11	35	theme	preferable	1914:1923	arg1	efficiency					1935:1944	the preferable antitumor efficiency	1910:1944	the preferable antitumor efficiency to other experimental groups in H22 tumor-bearing mice	1910:1999	Correspondingly, the DGL-GA-CDA-DOX-HA displayed the preferable antitumor efficiency to other experimental groups in H22 tumor-bearing mice, with a tumor inhibition rate of 71.6%.
33383133	3	36	dep	transform	701:709	arg1	infrared					711:718	infrared	711:718	transform infrared spectrometer (FTIR)	701:738	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	2	37	theme	doxorubicin	475:485	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	37	theme	doxorubicin	475:485	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	5	38	theme	DGL-GA-CDA-DOX	1091:1104	arg1	nanoparticles					1106:1118	DGL-GA-CDA-DOX nanoparticles	1091:1118	DGL-GA-CDA-DOX nanoparticles	1091:1118	The loading amount of DOX reached 252.03 ± 36.38 mg/g for DGL-GA-CDA-DOX nanoparticles.
33383133	0	39	theme	tumor	74:78	arg1	penetration					80:90	deep tumor penetration	69:90	deep tumor penetration	69:90	Size-shrinkable and protein kinase Cα-recognizable nanoparticles for deep tumor penetration and cellular internalization.
33383133	1	40	theme	single	314:319	arg1	platform					321:328	a single platform	312:328	a single platform in order to improve antitumor efficiency	312:369	In the present study, the three functions, including enhanced permeability and retention (EPR) effect, deep penetration within tumor, and receptor-mediated endocytosis, were integrated into a single platform in order to improve antitumor efficiency.
33383133	3	41	theme	dynamic	629:635	arg1	DLS					655:657	DLS	655:657	DLS	655:657	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	41	theme	dynamic	629:635	arg1	scattering					643:652	dynamic light scattering	629:652	dynamic light scattering (DLS)	629:658	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	9	42	theme	DOX-HA	1565:1570	arg1	nanoparticles					1572:1584	DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles	1535:1584	DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids	1535:1645	The study showed that the penetrability of DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids were always better than that of DGL-GA-CDA-DOX-HA nanoparticles untreated by HAase.
33383133	3	43	theme	dispersity	669:678	arg1	PDI					687:689	PDI	687:689	PDI	687:689	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	43	theme	dispersity	669:678	arg1	index					680:684	polymer dispersity index	661:684	polymer dispersity index (PDI)	661:690	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	11	44	theme	tumor	2009:2013	arg1	rate					2026:2029	a tumor inhibition rate	2007:2029	a tumor inhibition rate of 71.6%	2007:2038	Correspondingly, the DGL-GA-CDA-DOX-HA displayed the preferable antitumor efficiency to other experimental groups in H22 tumor-bearing mice, with a tumor inhibition rate of 71.6%.
33383133	9	45	theme	vitro	1611:1615	arg1	spheroids					1637:1645	vitro multicellular tumor spheroids	1611:1645	vitro multicellular tumor spheroids	1611:1645	The study showed that the penetrability of DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids were always better than that of DGL-GA-CDA-DOX-HA nanoparticles untreated by HAase.
33383133	1	46	theme	enhanced	175:182	arg1	effect					217:222	enhanced permeability and retention (EPR) effect	175:222	enhanced permeability and retention (EPR) effect	175:222	In the present study, the three functions, including enhanced permeability and retention (EPR) effect, deep penetration within tumor, and receptor-mediated endocytosis, were integrated into a single platform in order to improve antitumor efficiency.
33383133	11	47	theme	tumor-bearing	1982:1994	arg1	mice					1996:1999	H22 tumor-bearing mice	1978:1999	H22 tumor-bearing mice	1978:1999	Correspondingly, the DGL-GA-CDA-DOX-HA displayed the preferable antitumor efficiency to other experimental groups in H22 tumor-bearing mice, with a tumor inhibition rate of 71.6%.
33383133	9	48	theme	tumor	1631:1635	arg1	spheroids					1637:1645	vitro multicellular tumor spheroids	1611:1645	vitro multicellular tumor spheroids	1611:1645	The study showed that the penetrability of DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids were always better than that of DGL-GA-CDA-DOX-HA nanoparticles untreated by HAase.
33383133	12	49	theme	therapeutic	2126:2136	arg1	effects					2138:2144	therapeutic effects	2126:2144	therapeutic effects	2126:2144	In short, these results suggested that DGL-GA-CDA-DOX-HA nanoparticles could promote therapeutic effects by modulating particle size and GA receptor-mediated endocytosis.
33383133	4	50	theme	182.5	967:971	arg1	nm					973:974	nm	973:974	nm	973:974	According to the results of TEM and DLS, the DGL-GA-CDA-DOX-HA nanoparticles could be rapidly degraded with a size shrink from 182.5 nm to 47.7 nm by hyaluronidase (HAase) added in the medium.
33383133	3	51	theme	transmission	589:600	arg1	TEM					623:625	TEM	623:625	TEM	623:625	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	51	theme	transmission	589:600	arg1	microscope					611:620	The transmission electron microscope	585:620	The transmission electron microscope (TEM)	585:626	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	10	52	theme	in	1743:1744	arg1	imaging					1735:1741	The imaging	1731:1741	The imaging in vivo and ex vivo	1731:1761	The imaging in vivo and ex vivo exhibited that DGL-GA-CDA-DOX-HA nanoparticles could preferentially accumulate in the tumor site.
33383133	11	53	theme	%	2038:2038	arg1	rate					2026:2029	a tumor inhibition rate	2007:2029	a tumor inhibition rate of 71.6%	2007:2038	Correspondingly, the DGL-GA-CDA-DOX-HA displayed the preferable antitumor efficiency to other experimental groups in H22 tumor-bearing mice, with a tumor inhibition rate of 71.6%.
33383133	10	54	dep	ex	1755:1756	arg1	vivo					1758:1761	vivo	1758:1761	vivo	1758:1761	The imaging in vivo and ex vivo exhibited that DGL-GA-CDA-DOX-HA nanoparticles could preferentially accumulate in the tumor site.
33383133	7	55	theme	neutral	1297:1303	arg1	medium					1305:1310	a neutral medium	1295:1310	a neutral medium containing HAase	1295:1327	However, when the nanoparticles were exposed to a medium without HAase at pH 5.0, or a neutral medium containing HAase, drug release slowed down.
33383133	4	56	dep	nm	973:974	arg1	to					976:977	to	976:977	to	976:977	According to the results of TEM and DLS, the DGL-GA-CDA-DOX-HA nanoparticles could be rapidly degraded with a size shrink from 182.5 nm to 47.7 nm by hyaluronidase (HAase) added in the medium.
33383133	11	57	theme	other	1949:1953	arg1	groups					1968:1973	other experimental groups	1949:1973	other experimental groups	1949:1973	Correspondingly, the DGL-GA-CDA-DOX-HA displayed the preferable antitumor efficiency to other experimental groups in H22 tumor-bearing mice, with a tumor inhibition rate of 71.6%.
33383133	1	58	theme	present	129:135	arg1	study					137:141	the present study	125:141	the present study	125:141	In the present study, the three functions, including enhanced permeability and retention (EPR) effect, deep penetration within tumor, and receptor-mediated endocytosis, were integrated into a single platform in order to improve antitumor efficiency.
33383133	9	59	theme	DGL-GA-CDA-DOX-HA	1679:1695	arg1	nanoparticles					1697:1709	DGL-GA-CDA-DOX-HA nanoparticles	1679:1709	DGL-GA-CDA-DOX-HA nanoparticles untreated by HAase	1679:1728	The study showed that the penetrability of DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids were always better than that of DGL-GA-CDA-DOX-HA nanoparticles untreated by HAase.
33383133	11	60	from	efficiency	1935:1944	arg1	mice					1996:1999	H22 tumor-bearing mice	1978:1999	H22 tumor-bearing mice	1978:1999	Correspondingly, the DGL-GA-CDA-DOX-HA displayed the preferable antitumor efficiency to other experimental groups in H22 tumor-bearing mice, with a tumor inhibition rate of 71.6%.
33383133	6	61	from	pH	1175:1176	arg1	medium					1154:1159	a medium	1152:1159	a medium with HAase at pH 5.0	1152:1180	When the nanoparticles were in a medium with HAase at pH 5.0, the drug quickly released.
33383133	3	62	theme	light	637:641	arg1	DLS					655:657	DLS	655:657	DLS	655:657	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	62	theme	light	637:641	arg1	scattering					643:652	dynamic light scattering	629:652	dynamic light scattering (DLS)	629:658	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	9	63	theme	untreated	1711:1719	arg1	nanoparticles					1697:1709	DGL-GA-CDA-DOX-HA nanoparticles	1679:1709	DGL-GA-CDA-DOX-HA nanoparticles untreated by HAase	1679:1728	The study showed that the penetrability of DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids were always better than that of DGL-GA-CDA-DOX-HA nanoparticles untreated by HAase.
33383133	3	64	used	used	766:769	arg2	scattering					643:652	dynamic light scattering	629:652	dynamic light scattering (DLS)	629:658	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	64	used	used	766:769	arg2	PDI					687:689	PDI	687:689	PDI	687:689	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	64	used	used	766:769	arg2	fourier					693:699	fourier	693:699	fourier transform infrared spectrometer (FTIR)	693:738	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	64	used	used	766:769	arg2	index					680:684	polymer dispersity index	661:684	polymer dispersity index (PDI)	661:690	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	64	used	used	766:769	arg2	microscope					611:620	The transmission electron microscope	585:620	The transmission electron microscope (TEM)	585:626	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	64	used	used	766:769	arg2	potentials					750:759	zeta potentials	745:759	zeta potentials	745:759	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	64	used	used	766:769	arg2	DLS					655:657	DLS	655:657	DLS	655:657	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	64	used	used	766:769	arg2	TEM					623:625	TEM	623:625	TEM	623:625	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	65	theme	physicochemical	791:805	arg1	properties					807:816	the physicochemical properties	787:816	the physicochemical properties of the nanoparticles	787:837	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	11	66	theme	H22	1978:1980	arg1	mice					1996:1999	H22 tumor-bearing mice	1978:1999	H22 tumor-bearing mice	1978:1999	Correspondingly, the DGL-GA-CDA-DOX-HA displayed the preferable antitumor efficiency to other experimental groups in H22 tumor-bearing mice, with a tumor inhibition rate of 71.6%.
33383133	0	67	theme	cellular	96:103	arg1	internalization					105:119	cellular internalization	96:119	cellular internalization	96:119	Size-shrinkable and protein kinase Cα-recognizable nanoparticles for deep tumor penetration and cellular internalization.
33383133	6	68	with	medium	1154:1159	arg1	HAase					1166:1170	HAase	1166:1170	HAase	1166:1170	When the nanoparticles were in a medium with HAase at pH 5.0, the drug quickly released.
33383133	2	69	theme	acid	499:502	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	69	theme	acid	499:502	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	3	70	theme	nanoparticles	825:837	arg1	properties					807:816	the physicochemical properties	787:816	the physicochemical properties of the nanoparticles	787:837	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	5	71	theme	DOX	1055:1057	arg1	DOX					1055:1057	DOX	1055:1057	DOX	1055:1057	The loading amount of DOX reached 252.03 ± 36.38 mg/g for DGL-GA-CDA-DOX nanoparticles.
33383133	5	71	theme	DOX	1055:1057	arg1	amount					1045:1050	The loading amount	1033:1050	The loading amount of DOX	1033:1057	The loading amount of DOX reached 252.03 ± 36.38 mg/g for DGL-GA-CDA-DOX nanoparticles.
33383133	12	72	theme	DGL-GA-CDA-DOX-HA	2080:2096	arg1	nanoparticles					2098:2110	DGL-GA-CDA-DOX-HA nanoparticles	2080:2110	DGL-GA-CDA-DOX-HA nanoparticles	2080:2110	In short, these results suggested that DGL-GA-CDA-DOX-HA nanoparticles could promote therapeutic effects by modulating particle size and GA receptor-mediated endocytosis.
33383133	8	73	theme	carcinoma	1469:1477	arg1	cells					1485:1489	hepatocellular carcinoma HepG2 cells	1454:1489	hepatocellular carcinoma HepG2 cells	1454:1489	The modification of GA on nanoparticles significantly enhanced their affinity and cytotoxicity to hepatocellular carcinoma HepG2 cells.
33383133	2	74	theme	dicarboxylic	452:463	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	74	theme	dicarboxylic	452:463	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	75	theme	novel	374:378	arg1	DGL-GA-CDA-DOX-HA					566:582	DGL-GA-CDA-DOX-HA	566:582	DGL-GA-CDA-DOX-HA	566:582	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	75	theme	novel	374:378	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	75	theme	novel	374:378	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	0	76	theme	kinase	28:33	arg1	Cα-recognizable					35:49	protein kinase Cα-recognizable	20:49	protein kinase Cα-recognizable	20:49	Size-shrinkable and protein kinase Cα-recognizable nanoparticles for deep tumor penetration and cellular internalization.
33383133	2	77	theme	@	439:439	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	77	theme	@	439:439	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	10	78	theme	tumor	1849:1853	arg1	site					1855:1858	the tumor site	1845:1858	the tumor site	1845:1858	The imaging in vivo and ex vivo exhibited that DGL-GA-CDA-DOX-HA nanoparticles could preferentially accumulate in the tumor site.
33383133	2	79	theme	glycyrrhetinic	420:433	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	79	theme	glycyrrhetinic	420:433	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	3	80	dep	fourier	693:699	arg1	transform					701:709	transform	701:709	transform infrared spectrometer (FTIR)	701:738	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	2	81	theme	@	486:486	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	81	theme	@	486:486	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	12	82	theme	receptor-mediated	2181:2197	arg1	endocytosis					2199:2209	receptor-mediated endocytosis	2181:2209	receptor-mediated endocytosis	2181:2209	In short, these results suggested that DGL-GA-CDA-DOX-HA nanoparticles could promote therapeutic effects by modulating particle size and GA receptor-mediated endocytosis.
33383133	2	83	theme	poly-L-lysine	406:418	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	83	theme	poly-L-lysine	406:418	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	0	84	theme	deep	69:72	arg1	penetration					80:90	deep tumor penetration	69:90	deep tumor penetration	69:90	Size-shrinkable and protein kinase Cα-recognizable nanoparticles for deep tumor penetration and cellular internalization.
33383133	4	85	from	nm	984:985	arg1	shrink					955:960	a size shrink	948:960	a size shrink from 182.5 nm to 47.7 nm	948:985	According to the results of TEM and DLS, the DGL-GA-CDA-DOX-HA nanoparticles could be rapidly degraded with a size shrink from 182.5 nm to 47.7 nm by hyaluronidase (HAase) added in the medium.
33383133	9	86	theme	DGL-GA-CDA-DOX	1535:1548	arg1	nanoparticles					1572:1584	DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles	1535:1584	DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids	1535:1645	The study showed that the penetrability of DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids were always better than that of DGL-GA-CDA-DOX-HA nanoparticles untreated by HAase.
33383133	2	87	theme	@	474:474	arg1	composite					504:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite	394:512	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	2	87	theme	@	474:474	arg1	nanoparticle					380:391	A novel nanoparticle	372:391	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite)	372:513	A novel nanoparticle (dendrigraft poly-L-lysine@glycyrrhetinic acid@cyclohexane dicarboxylic anhydride@doxorubicin@ hyaluronic acid composite) has been successfully developed and was denoted as DGL-GA-CDA-DOX-HA.
33383133	9	88	theme	DGL-GA-CDA	1554:1563	arg1	nanoparticles					1572:1584	DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles	1535:1584	DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids	1535:1645	The study showed that the penetrability of DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids were always better than that of DGL-GA-CDA-DOX-HA nanoparticles untreated by HAase.
33383133	3	89	theme	polymer	661:667	arg1	PDI					687:689	PDI	687:689	PDI	687:689	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	3	89	theme	polymer	661:667	arg1	index					680:684	polymer dispersity index	661:684	polymer dispersity index (PDI)	661:690	The transmission electron microscope (TEM), dynamic light scattering (DLS), polymer dispersity index (PDI), fourier transform infrared spectrometer (FTIR), and zeta potentials were used to characterize the physicochemical properties of the nanoparticles.
33383133	12	90	theme	particle	2160:2167	arg1	size					2169:2172	particle size	2160:2172	particle size	2160:2172	In short, these results suggested that DGL-GA-CDA-DOX-HA nanoparticles could promote therapeutic effects by modulating particle size and GA receptor-mediated endocytosis.
33383133	1	91	theme	deep	225:228	arg1	penetration					230:240	deep penetration	225:240	deep penetration within tumor	225:253	In the present study, the three functions, including enhanced permeability and retention (EPR) effect, deep penetration within tumor, and receptor-mediated endocytosis, were integrated into a single platform in order to improve antitumor efficiency.
33383133	9	92	theme	nanoparticles	1572:1584	arg1	penetrability					1518:1530	the penetrability	1514:1530	the penetrability of DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids	1514:1645	The study showed that the penetrability of DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids were always better than that of DGL-GA-CDA-DOX-HA nanoparticles untreated by HAase.
33383133	9	92	theme	nanoparticles	1572:1584	arg1	better					1659:1664	better	1659:1664	better	1659:1664	The study showed that the penetrability of DGL-GA-CDA-DOX and DGL-GA-CDA DOX-HA nanoparticles pre-degraded by HAase in vitro multicellular tumor spheroids were always better than that of DGL-GA-CDA-DOX-HA nanoparticles untreated by HAase.
33444487	6	0	theme	polyvinyl	1069:1077	arg1	alcohol					1079:1085	polyvinyl alcohol	1069:1085	polyvinyl alcohol (PVA)	1069:1091	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	6	0	theme	polyvinyl	1069:1077	arg1	pyrrolidone					1050:1060	polyvinyl pyrrolidone	1040:1060	polyvinyl pyrrolidone (PVP)	1040:1066	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	6	0	theme	polyvinyl	1069:1077	arg1	PVA					1088:1090	PVA	1088:1090	PVA	1088:1090	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	5	1	dep	OBJECTIVES	759:768	arg1	endeavor					798:805	an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release	795:973	an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release	795:973	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	5	1	dep	OBJECTIVES	759:768	arg1	aim					774:776	The aim	770:776	The aim of the study	770:789	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	10	2	theme	%	1771:1771	arg1	CaCl2.2H2O					1801:1810	CaCl2.2H2O	1801:1810	CaCl2.2H2O	1801:1810	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	10	2	theme	%	1771:1771	arg1	dihydrate					1790:1798	0.03 wt% calcium chloride dihydrate	1764:1798	0.03 wt% calcium chloride dihydrate (CaCl2.2H2O)	1764:1811	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	12	3	theme	local	2141:2145	arg1	hydrogel					2076:2083	A linear hydrogel	2067:2083	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O	2067:2124	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O can serve as a local vehicle for the sustained delivery of insulin inside periodontal pockets.
33444487	12	3	theme	local	2141:2145	arg1	vehicle					2147:2153	a local vehicle	2139:2153	a local vehicle for the sustained delivery of insulin inside periodontal pockets	2139:2218	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O can serve as a local vehicle for the sustained delivery of insulin inside periodontal pockets.
33444487	3	4	theme	few	572:574	arg1	studies					596:602	very few in vitro or in vivo studies	567:602	very few in vitro or in vivo studies concerning the local application of insulin	567:646	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	5	5	theme	study	785:789	arg1	endeavor					798:805	an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release	795:973	an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release	795:973	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	5	5	theme	study	785:789	arg1	aim					774:776	The aim	770:776	The aim of the study	770:789	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	2	6	theme	human	408:412	arg1	tissues					414:420	human tissues	408:420	human tissues	408:420	Consequently, new discoveries are arising, a noteworthy portion of which employ hydrogels as delivery systems due to their high biocompatibility with and similarity to human tissues.
33444487	9	7	theme	homogenous	1608:1617	arg1	texture					1630:1636	homogenous one-phasic texture	1608:1636	homogenous one-phasic texture	1608:1636	RESULTS Out of the 5 formulations, 4 had homogenous one-phasic texture and their insulin release profiles in vitro ranged from a few hours to about 2 weeks.
33444487	10	8	theme	wt	1823:1824	arg1	water					1827:1831	66.8 wt% water	1818:1831	66.8 wt% water	1818:1831	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	2	9	theme	delivery	333:340	arg1	hydrogels					320:328	hydrogels	320:328	hydrogels	320:328	Consequently, new discoveries are arising, a noteworthy portion of which employ hydrogels as delivery systems due to their high biocompatibility with and similarity to human tissues.
33444487	2	9	theme	delivery	333:340	arg1	systems					342:348	delivery systems	333:348	delivery systems due to their high biocompatibility with and similarity to human tissues	333:420	Consequently, new discoveries are arising, a noteworthy portion of which employ hydrogels as delivery systems due to their high biocompatibility with and similarity to human tissues.
33444487	1	10	theme	interest	230:237	arg1	topic					202:206	a topic	200:206	a topic of rapidly increasing interest	200:237	BACKGROUND The application of local drugs as adjunctive periodontal treatment is a topic of rapidly increasing interest.
33444487	1	10	theme	interest	230:237	arg1	application					134:144	The application	130:144	The application of local drugs as adjunctive periodontal treatment	130:195	BACKGROUND The application of local drugs as adjunctive periodontal treatment is a topic of rapidly increasing interest.
33444487	1	11	theme	local	149:153	arg1	drugs					155:159	local drugs	149:159	local drugs as adjunctive periodontal treatment	149:195	BACKGROUND The application of local drugs as adjunctive periodontal treatment is a topic of rapidly increasing interest.
33444487	6	12	theme	injectability	1192:1204	arg1	terms					1158:1162	terms	1158:1162	terms of the hydrogel texture and injectability	1158:1204	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	9	13	theme	release	1656:1662	arg1	profiles					1664:1671	their insulin release profiles	1642:1671	their insulin release profiles	1642:1671	RESULTS Out of the 5 formulations, 4 had homogenous one-phasic texture and their insulin release profiles in vitro ranged from a few hours to about 2 weeks.
33444487	8	14	theme	incubated	1392:1400	arg1	samples					1402:1408	the incubated samples	1388:1408	the incubated samples	1388:1408	Specimens of the incubated samples were withdrawn daily to measure insulin concentrations by means of the ultraviolet (UV)-absorbance method; ultimately the cumulative release was calculated.
33444487	6	15	theme	texture	1180:1186	arg1	terms					1158:1162	terms	1158:1162	terms of the hydrogel texture and injectability	1158:1204	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	4	16	theme	soft	736:739	arg1	regeneration					712:723	regeneration	712:723	regeneration	712:723	These studies concluded that insulin promotes the recovery and regeneration of damaged soft and bone tissues.
33444487	4	16	theme	soft	736:739	arg1	recovery					699:706	recovery	699:706	recovery	699:706	These studies concluded that insulin promotes the recovery and regeneration of damaged soft and bone tissues.
33444487	10	17	theme	water	1827:1831	arg1	blend					1728:1732	The blend	1724:1732	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin,	1724:1863	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	5	18	theme	small	903:907	arg1	load					917:920	a small insulin load	901:920	a small insulin load	901:920	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	2	19	theme	noteworthy	285:294	arg1	portion					296:302	a noteworthy portion	283:302	a noteworthy portion	283:302	Consequently, new discoveries are arising, a noteworthy portion of which employ hydrogels as delivery systems due to their high biocompatibility with and similarity to human tissues.
33444487	4	20	theme	bone	745:748	arg1	tissues					750:756	bone tissues	745:756	bone tissues	745:756	These studies concluded that insulin promotes the recovery and regeneration of damaged soft and bone tissues.
33444487	10	21	theme	wt	1742:1743	arg1	PVP					1746:1748	26.5 wt% PVP	1737:1748	26.5 wt% PVP	1737:1748	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	5	22	theme	insulin	909:915	arg1	load					917:920	a small insulin load	901:920	a small insulin load	901:920	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	0	23	theme	potential	75:83	arg1	treatment					108:116	potential adjunctive periodontal treatment	75:116	potential adjunctive periodontal treatment	75:116	Preparation and characterization of insulin-loaded injectable hydrogels as potential adjunctive periodontal treatment.
33444487	2	24	theme	arising	274:280	arg1	portion					296:302	a noteworthy portion	283:302	a noteworthy portion	283:302	Consequently, new discoveries are arising, a noteworthy portion of which employ hydrogels as delivery systems due to their high biocompatibility with and similarity to human tissues.
33444487	1	25	theme	periodontal	175:185	arg1	treatment					187:195	adjunctive periodontal treatment	164:195	adjunctive periodontal treatment	164:195	BACKGROUND The application of local drugs as adjunctive periodontal treatment is a topic of rapidly increasing interest.
33444487	6	26	theme	chitosan	1001:1008	arg1	hydrogel					1010:1017	The chitosan hydrogel	997:1017	The chitosan hydrogel	997:1017	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	6	27	dep	MATERIAL	976:983	arg1	hydrogel					1010:1017	The chitosan hydrogel	997:1017	The chitosan hydrogel	997:1017	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	10	28	theme	favorable	1869:1877	arg1	release					1897:1903	favorable regular sustained release	1869:1903	favorable regular sustained release	1869:1903	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	0	29	theme	periodontal	96:106	arg1	treatment					108:116	potential adjunctive periodontal treatment	75:116	potential adjunctive periodontal treatment	75:116	Preparation and characterization of insulin-loaded injectable hydrogels as potential adjunctive periodontal treatment.
33444487	3	30	dep	in	588:589	arg1	vivo					591:594	vivo	591:594	vivo	591:594	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	3	31	theme	insulin	640:646	arg1	application					625:635	the local application	615:635	the local application of insulin	615:646	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	5	32	theme	sustained	957:965	arg1	release					967:973	sustained release	957:973	sustained release	957:973	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	4	33	dep	recovery	699:706	arg1	the					695:697	the	695:697	the	695:697	These studies concluded that insulin promotes the recovery and regeneration of damaged soft and bone tissues.
33444487	7	34	theme	formulation	1283:1293	arg1	amount					1268:1273	a specific amount	1257:1273	a specific amount of each formulation	1257:1293	Afterward, to study the insulin release kinetics, a specific amount of each formulation was loaded with insulin, and then incubated in phosphate-buffered saline (PBS).
33444487	7	34	theme	formulation	1283:1293	arg1	formulation					1283:1293	each formulation	1278:1293	each formulation	1278:1293	Afterward, to study the insulin release kinetics, a specific amount of each formulation was loaded with insulin, and then incubated in phosphate-buffered saline (PBS).
33444487	3	35	theme	new	441:443	arg1	agents					457:462	new therapeutic agents	441:462	new therapeutic agents capable of aiding periodontal treatment	441:502	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	5	36	theme	physical	930:937	arg1	bonds					939:943	physical bonds	930:943	physical bonds	930:943	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	6	37	theme	pyrrolidone	1050:1060	arg1	METHODS					989:995	METHODS	989:995	METHODS	989:995	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	6	37	theme	pyrrolidone	1050:1060	arg1	MATERIAL					976:983	MATERIAL	976:983	MATERIAL	976:983	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	6	37	theme	pyrrolidone	1050:1060	arg1	blends					1030:1035	blends	1030:1035	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG)	976:1121	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	11	38	theme	component	1976:1984	arg1	CONCLUSIONS					1927:1937	CONCLUSIONS The composition of the hydrogel	1927:1969	CONCLUSIONS The composition of the hydrogel	1927:1969	CONCLUSIONS The composition of the hydrogel, the component ratio and the amount of loaded insulin were found to affect the release profile.
33444487	11	38	theme	component	1976:1984	arg1	ratio					1986:1990	the component ratio	1972:1990	the component ratio	1972:1990	CONCLUSIONS The composition of the hydrogel, the component ratio and the amount of loaded insulin were found to affect the release profile.
33444487	3	39	theme	periodontal	482:492	arg1	treatment					494:502	periodontal treatment	482:502	periodontal treatment	482:502	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	7	40	theme	specific	1259:1266	arg1	amount					1268:1273	a specific amount	1257:1273	a specific amount of each formulation	1257:1293	Afterward, to study the insulin release kinetics, a specific amount of each formulation was loaded with insulin, and then incubated in phosphate-buffered saline (PBS).
33444487	7	40	theme	specific	1259:1266	arg1	formulation					1283:1293	each formulation	1278:1293	each formulation	1278:1293	Afterward, to study the insulin release kinetics, a specific amount of each formulation was loaded with insulin, and then incubated in phosphate-buffered saline (PBS).
33444487	11	41	theme	loaded	2010:2015	arg1	insulin					2017:2023	loaded insulin	2010:2023	loaded insulin	2010:2023	CONCLUSIONS The composition of the hydrogel, the component ratio and the amount of loaded insulin were found to affect the release profile.
33444487	9	42	contain	had	1604:1606	arg2	texture					1630:1636	homogenous one-phasic texture	1608:1636	homogenous one-phasic texture	1608:1636	RESULTS Out of the 5 formulations, 4 had homogenous one-phasic texture and their insulin release profiles in vitro ranged from a few hours to about 2 weeks.
33444487	9	42	contain	had	1604:1606	arg2	profiles					1664:1671	their insulin release profiles	1642:1671	their insulin release profiles	1642:1671	RESULTS Out of the 5 formulations, 4 had homogenous one-phasic texture and their insulin release profiles in vitro ranged from a few hours to about 2 weeks.
33444487	9	42	contain	had	1604:1606	arg1	4					1602:1602	4	1602:1602	4	1602:1602	RESULTS Out of the 5 formulations, 4 had homogenous one-phasic texture and their insulin release profiles in vitro ranged from a few hours to about 2 weeks.
33444487	10	43	theme	PVP	1746:1748	arg1	blend					1728:1732	The blend	1724:1732	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin,	1724:1863	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	11	44	theme	hydrogel	1962:1969	arg1	composition					1943:1953	The composition	1939:1953	CONCLUSIONS The composition of the hydrogel	1927:1969	CONCLUSIONS The composition of the hydrogel, the component ratio and the amount of loaded insulin were found to affect the release profile.
33444487	2	45	theme	high	363:366	arg1	biocompatibility					368:383	their high biocompatibility	357:383	their high biocompatibility with and similarity to human tissues	357:420	Consequently, new discoveries are arising, a noteworthy portion of which employ hydrogels as delivery systems due to their high biocompatibility with and similarity to human tissues.
33444487	12	46	theme	PVP	2102:2104	arg1	hydrogel					2076:2083	A linear hydrogel	2067:2083	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O	2067:2124	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O can serve as a local vehicle for the sustained delivery of insulin inside periodontal pockets.
33444487	12	46	theme	PVP	2102:2104	arg1	vehicle					2147:2153	a local vehicle	2139:2153	a local vehicle for the sustained delivery of insulin inside periodontal pockets	2139:2218	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O can serve as a local vehicle for the sustained delivery of insulin inside periodontal pockets.
33444487	7	47	theme	release	1239:1245	arg1	kinetics					1247:1254	the insulin release kinetics	1227:1254	the insulin release kinetics	1227:1254	Afterward, to study the insulin release kinetics, a specific amount of each formulation was loaded with insulin, and then incubated in phosphate-buffered saline (PBS).
33444487	10	48	theme	sustained	1887:1895	arg1	release					1897:1903	favorable regular sustained release	1869:1903	favorable regular sustained release	1869:1903	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	8	49	theme	cumulative	1532:1541	arg1	release					1543:1549	ultimately the cumulative release	1517:1549	ultimately the cumulative release	1517:1549	Specimens of the incubated samples were withdrawn daily to measure insulin concentrations by means of the ultraviolet (UV)-absorbance method; ultimately the cumulative release was calculated.
33444487	10	50	theme	%	1757:1757	arg1	PVA					1759:1761	6.6 wt% PVA	1751:1761	6.6 wt% PVA	1751:1761	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	3	51	theme	unique	536:541	arg1	concept					543:549	a unique concept	534:549	a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin	534:646	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	10	52	theme	calcium	1773:1779	arg1	CaCl2.2H2O					1801:1810	CaCl2.2H2O	1801:1810	CaCl2.2H2O	1801:1810	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	10	52	theme	calcium	1773:1779	arg1	dihydrate					1790:1798	0.03 wt% calcium chloride dihydrate	1764:1798	0.03 wt% calcium chloride dihydrate (CaCl2.2H2O)	1764:1811	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	10	53	theme	wt	1769:1770	arg1	CaCl2.2H2O					1801:1810	CaCl2.2H2O	1801:1810	CaCl2.2H2O	1801:1810	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	10	53	theme	wt	1769:1770	arg1	dihydrate					1790:1798	0.03 wt% calcium chloride dihydrate	1764:1798	0.03 wt% calcium chloride dihydrate (CaCl2.2H2O)	1764:1811	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	12	54	theme	sustained	2163:2171	arg1	delivery					2173:2180	the sustained delivery	2159:2180	the sustained delivery of insulin inside periodontal pockets	2159:2218	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O can serve as a local vehicle for the sustained delivery of insulin inside periodontal pockets.
33444487	6	55	theme	polyethylene	1097:1108	arg1	PEG					1118:1120	PEG	1118:1120	PEG	1118:1120	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	6	55	theme	polyethylene	1097:1108	arg1	glycol					1110:1115	polyethylene glycol	1097:1115	polyethylene glycol (PEG)	1097:1121	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	6	55	theme	polyethylene	1097:1108	arg1	pyrrolidone					1050:1060	polyvinyl pyrrolidone	1040:1060	polyvinyl pyrrolidone (PVP)	1040:1066	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	3	56	from	concept	543:549	arg1	interested					520:529	interested	520:529	interested	520:529	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	5	57	theme	periodontal	859:869	arg1	pockets					871:877	periodontal pockets	859:877	periodontal pockets	859:877	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	11	58	dep	CONCLUSIONS	1927:1937	arg1	composition					1943:1953	The composition	1939:1953	CONCLUSIONS The composition of the hydrogel	1927:1969	CONCLUSIONS The composition of the hydrogel, the component ratio and the amount of loaded insulin were found to affect the release profile.
33444487	10	59	theme	dihydrate	1790:1798	arg1	blend					1728:1732	The blend	1724:1732	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin,	1724:1863	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	9	60	theme	one-phasic	1619:1628	arg1	texture					1630:1636	homogenous one-phasic texture	1608:1636	homogenous one-phasic texture	1608:1636	RESULTS Out of the 5 formulations, 4 had homogenous one-phasic texture and their insulin release profiles in vitro ranged from a few hours to about 2 weeks.
33444487	10	61	theme	66.8	1818:1821	arg1	wt					1823:1824	wt	1823:1824	wt	1823:1824	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	3	62	from	interested	520:529	arg1	concept					543:549	a unique concept	534:549	a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin	534:646	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	3	63	theme	in	576:577	arg1	studies					596:602	very few in vitro or in vivo studies	567:602	very few in vitro or in vivo studies concerning the local application of insulin	567:646	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	1	64	theme	increasing	219:228	arg1	interest					230:237	rapidly increasing interest	211:237	rapidly increasing interest	211:237	BACKGROUND The application of local drugs as adjunctive periodontal treatment is a topic of rapidly increasing interest.
33444487	3	65	theme	in	588:589	arg1	studies					596:602	very few in vitro or in vivo studies	567:602	very few in vitro or in vivo studies concerning the local application of insulin	567:646	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	7	66	theme	phosphate-buffered	1342:1359	arg1	saline					1361:1366	phosphate-buffered saline	1342:1366	phosphate-buffered saline (PBS)	1342:1372	Afterward, to study the insulin release kinetics, a specific amount of each formulation was loaded with insulin, and then incubated in phosphate-buffered saline (PBS).
33444487	7	66	theme	phosphate-buffered	1342:1359	arg1	PBS					1369:1371	PBS	1369:1371	PBS	1369:1371	Afterward, to study the insulin release kinetics, a specific amount of each formulation was loaded with insulin, and then incubated in phosphate-buffered saline (PBS).
33444487	1	67	theme	adjunctive	164:173	arg1	treatment					187:195	adjunctive periodontal treatment	164:195	adjunctive periodontal treatment	164:195	BACKGROUND The application of local drugs as adjunctive periodontal treatment is a topic of rapidly increasing interest.
33444487	9	68	theme	insulin	1648:1654	arg1	profiles					1664:1671	their insulin release profiles	1642:1671	their insulin release profiles	1642:1671	RESULTS Out of the 5 formulations, 4 had homogenous one-phasic texture and their insulin release profiles in vitro ranged from a few hours to about 2 weeks.
33444487	8	69	theme	samples	1402:1408	arg1	Specimens					1375:1383	Specimens	1375:1383	Specimens of the incubated samples	1375:1408	Specimens of the incubated samples were withdrawn daily to measure insulin concentrations by means of the ultraviolet (UV)-absorbance method; ultimately the cumulative release was calculated.
33444487	9	70	dep	RESULTS	1567:1573	arg1	had					1604:1606	had	1604:1606	had homogenous one-phasic texture and their insulin release profiles in vitro	1604:1680	RESULTS Out of the 5 formulations, 4 had homogenous one-phasic texture and their insulin release profiles in vitro ranged from a few hours to about 2 weeks.
33444487	2	71	theme	new	254:256	arg1	discoveries					258:268	new discoveries	254:268	new discoveries	254:268	Consequently, new discoveries are arising, a noteworthy portion of which employ hydrogels as delivery systems due to their high biocompatibility with and similarity to human tissues.
33444487	12	72	theme	CaCl2.2H2O	2115:2124	arg1	hydrogel					2076:2083	A linear hydrogel	2067:2083	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O	2067:2124	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O can serve as a local vehicle for the sustained delivery of insulin inside periodontal pockets.
33444487	12	72	theme	CaCl2.2H2O	2115:2124	arg1	vehicle					2147:2153	a local vehicle	2139:2153	a local vehicle for the sustained delivery of insulin inside periodontal pockets	2139:2218	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O can serve as a local vehicle for the sustained delivery of insulin inside periodontal pockets.
33444487	6	73	theme	hydrogel	1171:1178	arg1	texture					1180:1186	the hydrogel texture	1167:1186	the hydrogel texture	1167:1186	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	10	74	theme	%	1825:1825	arg1	water					1827:1831	66.8 wt% water	1818:1831	66.8 wt% water	1818:1831	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	10	75	theme	%	1744:1744	arg1	PVP					1746:1748	26.5 wt% PVP	1737:1748	26.5 wt% PVP	1737:1748	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	1	76	theme	drugs	155:159	arg1	topic					202:206	a topic	200:206	a topic of rapidly increasing interest	200:237	BACKGROUND The application of local drugs as adjunctive periodontal treatment is a topic of rapidly increasing interest.
33444487	1	76	theme	drugs	155:159	arg1	application					134:144	The application	130:144	The application of local drugs as adjunctive periodontal treatment	130:195	BACKGROUND The application of local drugs as adjunctive periodontal treatment is a topic of rapidly increasing interest.
33444487	5	77	contain	carry	895:899	arg2	load					917:920	a small insulin load	901:920	a small insulin load	901:920	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	5	77	contain	carry	895:899	arg1	injectable					843:852	injectable	843:852	injectable	843:852	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	5	77	contain	carry	895:899	arg1	able					887:890	able	887:890	able	887:890	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	5	77	contain	carry	895:899	arg1	hydrogel					826:833	a linear hydrogel	817:833	a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds	817:943	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	0	78	theme	adjunctive	85:94	arg1	treatment					108:116	potential adjunctive periodontal treatment	75:116	potential adjunctive periodontal treatment	75:116	Preparation and characterization of insulin-loaded injectable hydrogels as potential adjunctive periodontal treatment.
33444487	3	79	theme	local	619:623	arg1	application					625:635	the local application	615:635	the local application of insulin	615:646	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	3	80	dep	in	576:577	arg1	vitro					579:583	vitro	579:583	vitro	579:583	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	8	81	theme	insulin	1442:1448	arg1	concentrations					1450:1463	insulin concentrations	1442:1463	insulin concentrations	1442:1463	Specimens of the incubated samples were withdrawn daily to measure insulin concentrations by means of the ultraviolet (UV)-absorbance method; ultimately the cumulative release was calculated.
33444487	9	82	theme	few	1696:1698	arg1	hours					1700:1704	a few hours	1694:1704	a few hours to about 2 weeks	1694:1721	RESULTS Out of the 5 formulations, 4 had homogenous one-phasic texture and their insulin release profiles in vitro ranged from a few hours to about 2 weeks.
33444487	12	83	theme	PVA	2107:2109	arg1	hydrogel					2076:2083	A linear hydrogel	2067:2083	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O	2067:2124	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O can serve as a local vehicle for the sustained delivery of insulin inside periodontal pockets.
33444487	12	83	theme	PVA	2107:2109	arg1	vehicle					2147:2153	a local vehicle	2139:2153	a local vehicle for the sustained delivery of insulin inside periodontal pockets	2139:2218	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O can serve as a local vehicle for the sustained delivery of insulin inside periodontal pockets.
33444487	1	84	dep	BACKGROUND	119:128	arg1	topic					202:206	a topic	200:206	a topic of rapidly increasing interest	200:237	BACKGROUND The application of local drugs as adjunctive periodontal treatment is a topic of rapidly increasing interest.
33444487	1	84	dep	BACKGROUND	119:128	arg1	application					134:144	The application	130:144	The application of local drugs as adjunctive periodontal treatment	130:195	BACKGROUND The application of local drugs as adjunctive periodontal treatment is a topic of rapidly increasing interest.
33444487	12	85	theme	linear	2069:2074	arg1	hydrogel					2076:2083	A linear hydrogel	2067:2083	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O	2067:2124	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O can serve as a local vehicle for the sustained delivery of insulin inside periodontal pockets.
33444487	12	85	theme	linear	2069:2074	arg1	vehicle					2147:2153	a local vehicle	2139:2153	a local vehicle for the sustained delivery of insulin inside periodontal pockets	2139:2218	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O can serve as a local vehicle for the sustained delivery of insulin inside periodontal pockets.
33444487	10	86	theme	insulin	1856:1862	arg1	IU/g					1848:1851	2 IU/g	1846:1851	2 IU/g of insulin	1846:1862	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	11	87	theme	release	2050:2056	arg1	profile					2058:2064	the release profile	2046:2064	the release profile	2046:2064	CONCLUSIONS The composition of the hydrogel, the component ratio and the amount of loaded insulin were found to affect the release profile.
33444487	3	88	theme	capable	464:470	arg1	agents					457:462	new therapeutic agents	441:462	new therapeutic agents capable of aiding periodontal treatment	441:502	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	10	89	contain	had	1865:1867	arg1	blend					1728:1732	The blend	1724:1732	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin,	1724:1863	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	10	89	contain	had	1865:1867	arg2	release					1897:1903	favorable regular sustained release	1869:1903	favorable regular sustained release	1869:1903	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	4	90	theme	tissues	750:756	arg1	regeneration					712:723	regeneration	712:723	regeneration	712:723	These studies concluded that insulin promotes the recovery and regeneration of damaged soft and bone tissues.
33444487	4	90	theme	tissues	750:756	arg1	recovery					699:706	recovery	699:706	recovery	699:706	These studies concluded that insulin promotes the recovery and regeneration of damaged soft and bone tissues.
33444487	3	91	theme	therapeutic	445:455	arg1	agents					457:462	new therapeutic agents	441:462	new therapeutic agents capable of aiding periodontal treatment	441:502	In the search for new therapeutic agents capable of aiding periodontal treatment, authors became interested in a unique concept investigated by very few in vitro or in vivo studies concerning the local application of insulin.
33444487	5	92	theme	linear	819:824	arg1	injectable					843:852	injectable	843:852	injectable	843:852	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	5	92	theme	linear	819:824	arg1	able					887:890	able	887:890	able	887:890	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	5	92	theme	linear	819:824	arg1	hydrogel					826:833	a linear hydrogel	817:833	a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds	817:943	OBJECTIVES The aim of the study was an endeavor to design a linear hydrogel that is injectable into periodontal pockets, and is able to carry a small insulin load through physical bonds and provide sustained release.
33444487	6	93	theme	polyvinyl	1040:1048	arg1	alcohol					1079:1085	polyvinyl alcohol	1069:1085	polyvinyl alcohol (PVA)	1069:1091	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	6	93	theme	polyvinyl	1040:1048	arg1	glycol					1110:1115	polyethylene glycol	1097:1115	polyethylene glycol (PEG)	1097:1121	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	6	93	theme	polyvinyl	1040:1048	arg1	PVP					1063:1065	PVP	1063:1065	PVP	1063:1065	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	6	93	theme	polyvinyl	1040:1048	arg1	pyrrolidone					1050:1060	polyvinyl pyrrolidone	1040:1060	polyvinyl pyrrolidone (PVP)	1040:1066	MATERIAL AND METHODS The chitosan hydrogel as well as blends of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and polyethylene glycol (PEG) were prepared and characterized in terms of the hydrogel texture and injectability.
33444487	8	94	theme	-absorbance	1497:1507	arg1	method					1509:1514	the ultraviolet (UV)-absorbance method	1477:1514	the ultraviolet (UV)-absorbance method	1477:1514	Specimens of the incubated samples were withdrawn daily to measure insulin concentrations by means of the ultraviolet (UV)-absorbance method; ultimately the cumulative release was calculated.
33444487	10	95	theme	wt	1755:1756	arg1	PVA					1759:1761	6.6 wt% PVA	1751:1761	6.6 wt% PVA	1751:1761	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	0	96	theme	injectable	51:60	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of insulin-loaded injectable hydrogels as potential adjunctive periodontal treatment.
33444487	0	96	theme	injectable	51:60	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of insulin-loaded injectable hydrogels as potential adjunctive periodontal treatment.
33444487	11	97	theme	insulin	2017:2023	arg1	CONCLUSIONS					1927:1937	CONCLUSIONS The composition of the hydrogel	1927:1969	CONCLUSIONS The composition of the hydrogel	1927:1969	CONCLUSIONS The composition of the hydrogel, the component ratio and the amount of loaded insulin were found to affect the release profile.
33444487	11	97	theme	insulin	2017:2023	arg1	ratio					1986:1990	the component ratio	1972:1990	the component ratio	1972:1990	CONCLUSIONS The composition of the hydrogel, the component ratio and the amount of loaded insulin were found to affect the release profile.
33444487	11	97	theme	insulin	2017:2023	arg1	amount					2000:2005	the amount	1996:2005	the amount of loaded insulin	1996:2023	CONCLUSIONS The composition of the hydrogel, the component ratio and the amount of loaded insulin were found to affect the release profile.
33444487	11	97	theme	insulin	2017:2023	arg1	insulin					2017:2023	loaded insulin	2010:2023	loaded insulin	2010:2023	CONCLUSIONS The composition of the hydrogel, the component ratio and the amount of loaded insulin were found to affect the release profile.
33444487	7	98	theme	insulin	1231:1237	arg1	kinetics					1247:1254	the insulin release kinetics	1227:1254	the insulin release kinetics	1227:1254	Afterward, to study the insulin release kinetics, a specific amount of each formulation was loaded with insulin, and then incubated in phosphate-buffered saline (PBS).
33444487	2	99	with	biocompatibility	368:383	arg1	similarity					394:403	and similarity	390:403	similarity	394:403	Consequently, new discoveries are arising, a noteworthy portion of which employ hydrogels as delivery systems due to their high biocompatibility with and similarity to human tissues.
33444487	12	100	theme	insulin	2185:2191	arg1	delivery					2173:2180	the sustained delivery	2159:2180	the sustained delivery of insulin inside periodontal pockets	2159:2218	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O can serve as a local vehicle for the sustained delivery of insulin inside periodontal pockets.
33444487	10	101	theme	PVA	1759:1761	arg1	blend					1728:1732	The blend	1724:1732	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin,	1724:1863	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	2	102	theme	due	350:352	arg1	hydrogels					320:328	hydrogels	320:328	hydrogels	320:328	Consequently, new discoveries are arising, a noteworthy portion of which employ hydrogels as delivery systems due to their high biocompatibility with and similarity to human tissues.
33444487	2	102	theme	due	350:352	arg1	systems					342:348	delivery systems	333:348	delivery systems due to their high biocompatibility with and similarity to human tissues	333:420	Consequently, new discoveries are arising, a noteworthy portion of which employ hydrogels as delivery systems due to their high biocompatibility with and similarity to human tissues.
33444487	10	103	theme	regular	1879:1885	arg1	release					1897:1903	favorable regular sustained release	1869:1903	favorable regular sustained release	1869:1903	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	12	104	theme	periodontal	2200:2210	arg1	pockets					2212:2218	periodontal pockets	2200:2218	periodontal pockets	2200:2218	A linear hydrogel of copolymerized PVP, PVA and CaCl2.2H2O can serve as a local vehicle for the sustained delivery of insulin inside periodontal pockets.
33444487	10	105	theme	chloride	1781:1788	arg1	CaCl2.2H2O					1801:1810	CaCl2.2H2O	1801:1810	CaCl2.2H2O	1801:1810	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33444487	10	105	theme	chloride	1781:1788	arg1	dihydrate					1790:1798	0.03 wt% calcium chloride dihydrate	1764:1798	0.03 wt% calcium chloride dihydrate (CaCl2.2H2O)	1764:1811	The blend of 26.5 wt% PVP, 6.6 wt% PVA, 0.03 wt% calcium chloride dihydrate (CaCl2.2H2O), and 66.8 wt% water, loaded with 2 IU/g of insulin, had favorable regular sustained release, approaching 13 days.
33920960	8	0	from	group	1155:1159	arg1	10-					1105:1107	10-	1105:1107	10-	1105:1107	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	8	0	from	group	1155:1159	arg1	Bifidobacterium					1023:1037	a specific Bifidobacterium	1012:1037	a specific Bifidobacterium	1012:1037	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	8	0	from	group	1155:1159	arg1	prevalent					1126:1134	prevalent	1126:1134	prevalent	1126:1134	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	4	1	from	intake	484:489	arg1	mice					494:497	mice	494:497	mice	494:497	In this study we determined the effect of curdlan intake in mice on the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation.
33920960	10	2	theme	microbiota	1410:1419	arg1	changes					1421:1427	microbiota changes	1410:1427	microbiota changes that could reduce intestinal inflammation	1410:1469	Overall, these results suggest that dietary curdlan induces microbiota changes that could reduce intestinal inflammation.
33920960	4	3	theme	intake	484:489	arg1	effect					466:471	the effect	462:471	the effect of curdlan intake in mice on the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation	462:591	In this study we determined the effect of curdlan intake in mice on the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation.
33920960	6	4	with	gavage	755:760	arg1	curdlan					778:784	curdlan	778:784	curdlan	778:784	Mice received oral gavage with vehicle or curdlan for 14 days followed by DSS for 7 days.
33920960	6	4	with	gavage	755:760	arg1	vehicle					767:773	vehicle	767:773	vehicle	767:773	Mice received oral gavage with vehicle or curdlan for 14 days followed by DSS for 7 days.
33920960	7	5	theme	vehicle-fed	916:926	arg1	group					928:932	the vehicle-fed group	912:932	the vehicle-fed group	912:932	The curdlan-fed group showed reduced weight loss and colonic inflammation compared to the vehicle-fed group.
33920960	4	6	from	effect	466:471	arg1	microbiota					517:526	the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation	502:591	microbiota	517:526	In this study we determined the effect of curdlan intake in mice on the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation.
33920960	4	6	from	effect	466:471	arg1	mice					494:497	mice	494:497	mice	494:497	In this study we determined the effect of curdlan intake in mice on the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation.
33920960	4	6	from	effect	466:471	arg1	inflammation					580:591	the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation	502:591	inflammation	580:591	In this study we determined the effect of curdlan intake in mice on the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation.
33920960	8	7	theme	community	984:992	arg1	changes					994:1000	general microbiota community changes	965:1000	general microbiota community changes	965:1000	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	5	8	theme	curdlan	608:614	arg1	effect					598:603	The effect	594:603	The effect of curdlan on the human intestinal microbiota	594:649	The effect of curdlan on the human intestinal microbiota was assessed using i-screen, an assay for studying anaerobic microbial interactions.
33920960	4	9	theme	curdlan	476:482	arg1	intake					484:489	curdlan intake	476:489	curdlan intake in mice	476:497	In this study we determined the effect of curdlan intake in mice on the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation.
33920960	8	10	dep	prevalent	1126:1134	arg1	10-					1105:1107	10-	1105:1107	10-	1105:1107	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	8	10	dep	prevalent	1126:1134	arg1	prevalent					1126:1134	prevalent	1126:1134	prevalent	1126:1134	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	8	10	dep	prevalent	1126:1134	arg1	Bifidobacterium					1023:1037	a specific Bifidobacterium	1012:1037	a specific Bifidobacterium	1012:1037	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	9	11	theme	global	1256:1261	arg1	change					1263:1268	a global change	1254:1268	a global change in the microbial composition of the healthy intestinal microbiota from a human	1254:1347	When tested in i-screen, curdlan induced a global change in the microbial composition of the healthy intestinal microbiota from a human.
33920960	0	12	from	Inflammation	63:74	arg1	Mice					79:82	Mice	79:82	Mice	79:82	Dietary Curdlan Enhances Bifidobacteria and Reduces Intestinal Inflammation in Mice.
33920960	2	13	theme	intestinal	262:271	arg1	microbes					273:280	certain intestinal microbes	254:280	certain intestinal microbes	254:280	While humans and mice lack the required enzymes to digest β-glucans, certain intestinal microbes can digest β-glucans, triggering gut microbial changes.
33920960	3	14	used	used	409:412	arg2	Curdlan					338:344	Curdlan	338:344	Curdlan	338:344	Curdlan, a particulate β-glucan isolated from Alcaligenes faecalis, is used as a food additive.
33920960	3	14	used	used	409:412	arg2	additive					424:431	additive	424:431	additive	424:431	Curdlan, a particulate β-glucan isolated from Alcaligenes faecalis, is used as a food additive.
33920960	3	14	used	used	409:412	arg2	β-glucan					361:368	a particulate β-glucan	347:368	a particulate β-glucan isolated from Alcaligenes faecalis	347:403	Curdlan, a particulate β-glucan isolated from Alcaligenes faecalis, is used as a food additive.
33920960	8	15	theme	specific	1014:1021	arg1	10-					1105:1107	10-	1105:1107	10-	1105:1107	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	8	15	theme	specific	1014:1021	arg1	prevalent					1126:1134	prevalent	1126:1134	prevalent	1126:1134	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	8	15	theme	specific	1014:1021	arg1	Bifidobacterium					1023:1037	a specific Bifidobacterium	1012:1037	a specific Bifidobacterium	1012:1037	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	2	16	theme	certain	254:260	arg1	microbes					273:280	certain intestinal microbes	254:280	certain intestinal microbes	254:280	While humans and mice lack the required enzymes to digest β-glucans, certain intestinal microbes can digest β-glucans, triggering gut microbial changes.
33920960	5	17	theme	anaerobic	702:710	arg1	interactions					722:733	anaerobic microbial interactions	702:733	anaerobic microbial interactions	702:733	The effect of curdlan on the human intestinal microbiota was assessed using i-screen, an assay for studying anaerobic microbial interactions.
33920960	8	18	dep	10-	1105:1107	arg1	to					1109:1110	to	1109:1110	to	1109:1110	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	10	19	theme	intestinal	1447:1456	arg1	inflammation					1458:1469	intestinal inflammation	1447:1469	intestinal inflammation	1447:1469	Overall, these results suggest that dietary curdlan induces microbiota changes that could reduce intestinal inflammation.
33920960	1	20	theme	β-glucan	85:92	arg1	consumption					94:104	β-glucan consumption	85:104	β-glucan consumption	85:104	β-glucan consumption is known for its beneficial health effects, but the mode of action is unclear.
33920960	1	21	theme	action	166:171	arg1	unclear					176:182	unclear	176:182	unclear	176:182	β-glucan consumption is known for its beneficial health effects, but the mode of action is unclear.
33920960	1	21	theme	action	166:171	arg1	mode					158:161	the mode	154:161	the mode of action	154:171	β-glucan consumption is known for its beneficial health effects, but the mode of action is unclear.
33920960	8	22	theme	curdlan-fed	1143:1153	arg1	group					1155:1159	the curdlan-fed group	1139:1159	the curdlan-fed group	1139:1159	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	9	23	theme	microbial	1277:1285	arg1	composition					1287:1297	the microbial composition	1273:1297	the microbial composition of the healthy intestinal microbiota	1273:1334	When tested in i-screen, curdlan induced a global change in the microbial composition of the healthy intestinal microbiota from a human.
33920960	10	24	theme	dietary	1386:1392	arg1	curdlan					1394:1400	dietary curdlan	1386:1400	dietary curdlan	1386:1400	Overall, these results suggest that dietary curdlan induces microbiota changes that could reduce intestinal inflammation.
33920960	0	25	theme	Dietary	0:6	arg1	Curdlan					8:14	Dietary Curdlan	0:14	Dietary Curdlan	0:14	Dietary Curdlan Enhances Bifidobacteria and Reduces Intestinal Inflammation in Mice.
33920960	5	26	from	effect	598:603	arg1	microbiota					640:649	the human intestinal microbiota	619:649	the human intestinal microbiota	619:649	The effect of curdlan on the human intestinal microbiota was assessed using i-screen, an assay for studying anaerobic microbial interactions.
33920960	6	27	theme	oral	750:753	arg1	gavage					755:760	oral gavage	750:760	oral gavage with vehicle or curdlan for 14 days followed by DSS for 7 days	750:823	Mice received oral gavage with vehicle or curdlan for 14 days followed by DSS for 7 days.
33920960	8	28	theme	microbiota	973:982	arg1	changes					994:1000	general microbiota community changes	965:1000	general microbiota community changes	965:1000	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	3	29	theme	particulate	349:359	arg1	Curdlan					338:344	Curdlan	338:344	Curdlan	338:344	Curdlan, a particulate β-glucan isolated from Alcaligenes faecalis, is used as a food additive.
33920960	3	29	theme	particulate	349:359	arg1	β-glucan					361:368	a particulate β-glucan	347:368	a particulate β-glucan isolated from Alcaligenes faecalis	347:403	Curdlan, a particulate β-glucan isolated from Alcaligenes faecalis, is used as a food additive.
33920960	4	30	theme	intestinal	506:515	arg1	microbiota					517:526	the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation	502:591	microbiota	517:526	In this study we determined the effect of curdlan intake in mice on the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation.
33920960	8	31	theme	related	1048:1054	arg1	10-					1105:1107	10-	1105:1107	10-	1105:1107	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	8	31	theme	related	1048:1054	arg1	prevalent					1126:1134	prevalent	1126:1134	prevalent	1126:1134	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	8	31	theme	related	1048:1054	arg1	Bifidobacterium					1023:1037	a specific Bifidobacterium	1012:1037	a specific Bifidobacterium	1012:1037	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	7	32	theme	colonic	879:885	arg1	inflammation					887:898	colonic inflammation	879:898	colonic inflammation	879:898	The curdlan-fed group showed reduced weight loss and colonic inflammation compared to the vehicle-fed group.
33920960	8	33	theme	Curdlan	935:941	arg1	intake					943:948	Curdlan intake	935:948	Curdlan intake	935:948	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	2	34	theme	microbial	319:327	arg1	changes					329:335	gut microbial changes	315:335	gut microbial changes	315:335	While humans and mice lack the required enzymes to digest β-glucans, certain intestinal microbes can digest β-glucans, triggering gut microbial changes.
33920960	2	35	theme	required	216:223	arg1	enzymes					225:231	the required enzymes	212:231	the required enzymes to digest β-glucans	212:251	While humans and mice lack the required enzymes to digest β-glucans, certain intestinal microbes can digest β-glucans, triggering gut microbial changes.
33920960	9	36	theme	intestinal	1314:1323	arg1	microbiota					1325:1334	the healthy intestinal microbiota	1302:1334	the healthy intestinal microbiota	1302:1334	When tested in i-screen, curdlan induced a global change in the microbial composition of the healthy intestinal microbiota from a human.
33920960	8	37	dep	control	1167:1173	arg1	conditions					1187:1196	conditions	1187:1196	conditions	1187:1196	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	9	38	from	change	1263:1268	arg1	composition					1287:1297	the microbial composition	1273:1297	the microbial composition of the healthy intestinal microbiota	1273:1334	When tested in i-screen, curdlan induced a global change in the microbial composition of the healthy intestinal microbiota from a human.
33920960	3	39	theme	Alcaligenes	384:394	arg1	faecalis					396:403	Alcaligenes faecalis	384:403	Alcaligenes faecalis	384:403	Curdlan, a particulate β-glucan isolated from Alcaligenes faecalis, is used as a food additive.
33920960	9	40	theme	microbiota	1325:1334	arg1	composition					1287:1297	the microbial composition	1273:1297	the microbial composition of the healthy intestinal microbiota	1273:1334	When tested in i-screen, curdlan induced a global change in the microbial composition of the healthy intestinal microbiota from a human.
33920960	5	41	theme	intestinal	629:638	arg1	microbiota					640:649	the human intestinal microbiota	619:649	the human intestinal microbiota	619:649	The effect of curdlan on the human intestinal microbiota was assessed using i-screen, an assay for studying anaerobic microbial interactions.
33920960	0	42	theme	Intestinal	52:61	arg1	Inflammation					63:74	Intestinal Inflammation	52:74	Intestinal Inflammation in Mice	52:82	Dietary Curdlan Enhances Bifidobacteria and Reduces Intestinal Inflammation in Mice.
33920960	8	43	from	prevalent	1126:1134	arg1	group					1155:1159	the curdlan-fed group	1139:1159	the curdlan-fed group	1139:1159	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	1	44	theme	beneficial	123:132	arg1	effects					141:147	its beneficial health effects	119:147	its beneficial health effects	119:147	β-glucan consumption is known for its beneficial health effects, but the mode of action is unclear.
33920960	7	45	theme	weight	863:868	arg1	loss					870:873	reduced weight loss	855:873	reduced weight loss	855:873	The curdlan-fed group showed reduced weight loss and colonic inflammation compared to the vehicle-fed group.
33920960	8	46	theme	general	965:971	arg1	changes					994:1000	general microbiota community changes	965:1000	general microbiota community changes	965:1000	Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively.
33920960	9	47	from	human	1343:1347	arg1	change					1263:1268	a global change	1254:1268	a global change in the microbial composition of the healthy intestinal microbiota from a human	1254:1347	When tested in i-screen, curdlan induced a global change in the microbial composition of the healthy intestinal microbiota from a human.
33920960	3	48	attach	isolated	370:377	arg1	faecalis					396:403	Alcaligenes faecalis	384:403	Alcaligenes faecalis	384:403	Curdlan, a particulate β-glucan isolated from Alcaligenes faecalis, is used as a food additive.
33920960	3	48	attach	isolated	370:377	arg2	Curdlan					338:344	Curdlan	338:344	Curdlan	338:344	Curdlan, a particulate β-glucan isolated from Alcaligenes faecalis, is used as a food additive.
33920960	3	48	attach	isolated	370:377	arg2	β-glucan					361:368	a particulate β-glucan	347:368	a particulate β-glucan isolated from Alcaligenes faecalis	347:403	Curdlan, a particulate β-glucan isolated from Alcaligenes faecalis, is used as a food additive.
33920960	9	49	theme	healthy	1306:1312	arg1	microbiota					1325:1334	the healthy intestinal microbiota	1302:1334	the healthy intestinal microbiota	1302:1334	When tested in i-screen, curdlan induced a global change in the microbial composition of the healthy intestinal microbiota from a human.
33920960	1	50	theme	health	134:139	arg1	effects					141:147	its beneficial health effects	119:147	its beneficial health effects	119:147	β-glucan consumption is known for its beneficial health effects, but the mode of action is unclear.
33920960	4	51	theme	-induced	560:567	arg1	inflammation					580:591	the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation	502:591	inflammation	580:591	In this study we determined the effect of curdlan intake in mice on the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation.
33920960	2	52	theme	gut	315:317	arg1	changes					329:335	gut microbial changes	315:335	gut microbial changes	315:335	While humans and mice lack the required enzymes to digest β-glucans, certain intestinal microbes can digest β-glucans, triggering gut microbial changes.
33920960	5	53	theme	microbial	712:720	arg1	interactions					722:733	anaerobic microbial interactions	702:733	anaerobic microbial interactions	702:733	The effect of curdlan on the human intestinal microbiota was assessed using i-screen, an assay for studying anaerobic microbial interactions.
33920960	7	54	theme	reduced	855:861	arg1	loss					870:873	reduced weight loss	855:873	reduced weight loss	855:873	The curdlan-fed group showed reduced weight loss and colonic inflammation compared to the vehicle-fed group.
33920960	5	55	theme	human	623:627	arg1	microbiota					640:649	the human intestinal microbiota	619:649	the human intestinal microbiota	619:649	The effect of curdlan on the human intestinal microbiota was assessed using i-screen, an assay for studying anaerobic microbial interactions.
33920960	4	56	from	mice	494:497	arg1	effect					466:471	the effect	462:471	the effect of curdlan intake in mice on the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation	462:591	In this study we determined the effect of curdlan intake in mice on the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation.
33920960	7	57	theme	curdlan-fed	830:840	arg1	group					842:846	The curdlan-fed group	826:846	The curdlan-fed group	826:846	The curdlan-fed group showed reduced weight loss and colonic inflammation compared to the vehicle-fed group.
33920960	4	58	theme	intestinal	569:578	arg1	inflammation					580:591	the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation	502:591	inflammation	580:591	In this study we determined the effect of curdlan intake in mice on the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation.
32895940	2	0	theme	paddy	353:357	arg1	varieties					359:367	12 different paddy varieties	340:367	12 different paddy varieties of India	340:376	To understand this hydration behavior, the current study analyses the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures.
32895940	2	0	theme	paddy	353:357	arg1	India					372:376	India	372:376	India	372:376	To understand this hydration behavior, the current study analyses the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures.
32895940	15	1	theme	process	2139:2145	arg1	parameters					2147:2156	process parameters	2139:2156	process parameters	2139:2156	Knowledge about the hydration behavior of paddy would enable food processors to better understand the effect of process parameters and to model their experimental setup to obtain the desired physicochemical attributes, as well as process yield.
32895940	9	2	theme	paddy	1341:1345	arg1	samples					1347:1353	the paddy samples	1337:1353	the paddy samples	1337:1353	The activation energy for the paddy samples in this investigation was found to be in the range of 8.70 to 23.10 kJ/mol.
32895940	8	3	theme	time-temperature	1172:1187	arg1	range					1199:1203	The optimum time-temperature condition range	1160:1203	The optimum time-temperature condition range for hydration for each paddy variety	1160:1240	The optimum time-temperature condition range for hydration for each paddy variety was between 50 and 60°C for 2 to 3.5 hr, depending upon the variety.
32895940	10	4	theme	hydration	1455:1463	arg1	modeling					1443:1450	The kinetic modeling	1431:1450	The kinetic modeling of hydration	1431:1463	The kinetic modeling of hydration was conducted using Peleg's model, with a good fit.
32895940	7	5	theme	83.10 °C	1040:1047	arg1	range					1022:1026	the range	1018:1026	the range of 65.60 to 83.10 °C, which in turn was negatively correlated with amylose content,	1018:1110	For all samples, the gelatinization temperature was in the range of 65.60 to 83.10 °C, which in turn was negatively correlated with amylose content, and influenced the hydration behavior of paddy.
32895940	1	6	theme	hydration	191:199	arg1	kinetics					201:208	hydration kinetics	191:208	hydration kinetics	191:208	Temperature is an important factor in the determination of hydration kinetics in paddy, and it varies with variety.
32895940	5	7	theme	amylose	845:851	arg1	content					853:859	higher amylose content	838:859	higher amylose content of paddy	838:868	An increased hydration rate was observed with increasing hydration temperature as well as with higher amylose content of paddy.
32895940	15	8	theme	desired	2210:2216	arg1	attributes					2234:2243	the desired physicochemical attributes	2206:2243	the desired physicochemical attributes	2206:2243	Knowledge about the hydration behavior of paddy would enable food processors to better understand the effect of process parameters and to model their experimental setup to obtain the desired physicochemical attributes, as well as process yield.
32895940	4	9	from	composition	593:603	arg1	time-temperature					648:663	time-temperature	648:663	time-temperature of hydration	648:676	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
32895940	8	10	dep	3.5	1275:1277	arg1	to					1272:1273	to	1272:1273	to	1272:1273	The optimum time-temperature condition range for hydration for each paddy variety was between 50 and 60°C for 2 to 3.5 hr, depending upon the variety.
32895940	6	11	theme	amylose	913:919	arg1	ratio					904:908	the ratio	900:908	the ratio of amylose to amylopectin	900:934	Among the varieties studied, the ratio of amylose to amylopectin was between 0.37 and 0.77.
32895940	11	12	from	decrease	1641:1648	arg1	constant					1698:1705	capacity constant	1689:1705	capacity constant (K2 )	1689:1711	The data indicated that with increment in hydration temperature, the rate of hydration was enhanced in all varieties with a decrease in the Peleg's rate constant (K1 ) and capacity constant (K2 ).
32895940	11	12	from	decrease	1641:1648	arg1	K1					1680:1681	K1	1680:1681	K1	1680:1681	The data indicated that with increment in hydration temperature, the rate of hydration was enhanced in all varieties with a decrease in the Peleg's rate constant (K1 ) and capacity constant (K2 ).
32895940	11	12	from	decrease	1641:1648	arg1	K2					1708:1709	K2	1708:1709	K2	1708:1709	The data indicated that with increment in hydration temperature, the rate of hydration was enhanced in all varieties with a decrease in the Peleg's rate constant (K1 ) and capacity constant (K2 ).
32895940	11	12	from	decrease	1641:1648	arg1	constant					1670:1677	the Peleg's rate constant	1653:1677	the Peleg's rate constant (K1 )	1653:1683	The data indicated that with increment in hydration temperature, the rate of hydration was enhanced in all varieties with a decrease in the Peleg's rate constant (K1 ) and capacity constant (K2 ).
32895940	4	13	theme	paddy	608:612	arg1	varieties					614:622	paddy varieties	608:622	paddy varieties as well as variation in time-temperature of hydration	608:676	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
32895940	10	14	theme	good	1507:1510	arg1	fit					1512:1514	a good fit	1505:1514	a good fit	1505:1514	The kinetic modeling of hydration was conducted using Peleg's model, with a good fit.
32895940	7	15	theme	amylose	1095:1101	arg1	content					1103:1109	amylose content	1095:1109	amylose content	1095:1109	For all samples, the gelatinization temperature was in the range of 65.60 to 83.10 °C, which in turn was negatively correlated with amylose content, and influenced the hydration behavior of paddy.
32895940	13	16	from	procedure	1863:1871	arg1	processing					1882:1891	paddy processing	1876:1891	paddy processing	1876:1891	PRACTICAL APPLICATION: The hydration of paddy is an important procedure in paddy processing, and across the world, many industries are working on it.
32895940	13	16	from	procedure	1863:1871	arg1	it					1947:1948	it	1947:1948	it	1947:1948	PRACTICAL APPLICATION: The hydration of paddy is an important procedure in paddy processing, and across the world, many industries are working on it.
32895940	16	17	theme	hydrated	2450:2457	arg1	paddy					2459:2463	the hydrated paddy	2446:2463	the hydrated paddy more affordable	2446:2479	Customers would benefit from adequately processed paddy with better digestibility for which industry would have to invest less in terms of time and resources, thereby making the hydrated paddy more affordable.
32895940	7	18	dep	83.10 °C	1040:1047	arg1	to					1037:1038	to	1037:1038	to	1037:1038	For all samples, the gelatinization temperature was in the range of 65.60 to 83.10 °C, which in turn was negatively correlated with amylose content, and influenced the hydration behavior of paddy.
32895940	3	19	dep	9.19	512:515	arg1	to					509:510	to	509:510	to	509:510	The protein content of the paddy samples was found to be in the range of 6.13 to 9.19%; whereas, starch content was between 67.79 and 84.88%.
32895940	3	20	theme	%	516:516	arg1	range					495:499	the range	491:499	the range of 6.13 to 9.19%	491:516	The protein content of the paddy samples was found to be in the range of 6.13 to 9.19%; whereas, starch content was between 67.79 and 84.88%.
32895940	1	21	theme	important	150:158	arg1	Temperature					132:142	Temperature	132:142	Temperature	132:142	Temperature is an important factor in the determination of hydration kinetics in paddy, and it varies with variety.
32895940	1	21	theme	important	150:158	arg1	factor					160:165	an important factor	147:165	an important factor in the determination of hydration kinetics in paddy	147:217	Temperature is an important factor in the determination of hydration kinetics in paddy, and it varies with variety.
32895940	13	22	dep	APPLICATION	1811:1821	arg1	working					1936:1942	working	1936:1942	working	1936:1942	PRACTICAL APPLICATION: The hydration of paddy is an important procedure in paddy processing, and across the world, many industries are working on it.
32895940	13	22	dep	APPLICATION	1811:1821	arg1	procedure					1863:1871	an important procedure	1850:1871	an important procedure in paddy processing	1850:1891	PRACTICAL APPLICATION: The hydration of paddy is an important procedure in paddy processing, and across the world, many industries are working on it.
32895940	13	22	dep	APPLICATION	1811:1821	arg1	hydration					1828:1836	The hydration	1824:1836	The hydration of paddy	1824:1845	PRACTICAL APPLICATION: The hydration of paddy is an important procedure in paddy processing, and across the world, many industries are working on it.
32895940	0	23	theme	varieties	65:73	arg1	behavior					40:47	hydration behavior	30:47	hydration behavior of Indian paddy varieties	30:73	Empirical characterization of hydration behavior of Indian paddy varieties by physicochemical characterization and kinetic studies.
32895940	12	24	from	temperature-dependence	1748:1769	arg1	paddy					1794:1798	paddy	1794:1798	paddy	1794:1798	These constants indicate a direct temperature-dependence of water absorption in paddy.
32895940	0	25	theme	physicochemical	78:92	arg1	characterization					94:109	physicochemical characterization	78:109	physicochemical characterization	78:109	Empirical characterization of hydration behavior of Indian paddy varieties by physicochemical characterization and kinetic studies.
32895940	4	26	theme	hydration	723:731	arg1	behavior					733:740	the hydration behavior	719:740	the hydration behavior	719:740	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
32895940	12	27	theme	water	1774:1778	arg1	absorption					1780:1789	water absorption	1774:1789	water absorption	1774:1789	These constants indicate a direct temperature-dependence of water absorption in paddy.
32895940	1	28	from	factor	160:165	arg1	determination					174:186	the determination	170:186	the determination of hydration kinetics in paddy	170:217	Temperature is an important factor in the determination of hydration kinetics in paddy, and it varies with variety.
32895940	15	29	theme	hydration	2047:2055	arg1	behavior					2057:2064	the hydration behavior	2043:2064	the hydration behavior of paddy	2043:2073	Knowledge about the hydration behavior of paddy would enable food processors to better understand the effect of process parameters and to model their experimental setup to obtain the desired physicochemical attributes, as well as process yield.
32895940	0	30	theme	Empirical	0:8	arg1	characterization					10:25	Empirical characterization	0:25	Empirical characterization of hydration behavior of Indian paddy varieties by physicochemical characterization and kinetic studies.	0:130	Empirical characterization of hydration behavior of Indian paddy varieties by physicochemical characterization and kinetic studies.
32895940	11	31	from	increment	1546:1554	arg1	temperature					1569:1579	hydration temperature	1559:1579	hydration temperature	1559:1579	The data indicated that with increment in hydration temperature, the rate of hydration was enhanced in all varieties with a decrease in the Peleg's rate constant (K1 ) and capacity constant (K2 ).
32895940	3	32	theme	samples	464:470	arg1	content					443:449	The protein content	431:449	The protein content of the paddy samples	431:470	The protein content of the paddy samples was found to be in the range of 6.13 to 9.19%; whereas, starch content was between 67.79 and 84.88%.
32895940	2	33	theme	soaking	409:415	arg1	temperatures					417:428	different soaking temperatures	399:428	different soaking temperatures	399:428	To understand this hydration behavior, the current study analyses the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures.
32895940	0	34	theme	behavior	40:47	arg1	characterization					10:25	Empirical characterization	0:25	Empirical characterization of hydration behavior of Indian paddy varieties by physicochemical characterization and kinetic studies.	0:130	Empirical characterization of hydration behavior of Indian paddy varieties by physicochemical characterization and kinetic studies.
32895940	5	35	theme	increased	746:754	arg1	rate					766:769	An increased hydration rate	743:769	An increased hydration rate	743:769	An increased hydration rate was observed with increasing hydration temperature as well as with higher amylose content of paddy.
32895940	2	36	theme	different	343:351	arg1	varieties					359:367	12 different paddy varieties	340:367	12 different paddy varieties of India	340:376	To understand this hydration behavior, the current study analyses the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures.
32895940	2	36	theme	different	343:351	arg1	India					372:376	India	372:376	India	372:376	To understand this hydration behavior, the current study analyses the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures.
32895940	0	37	theme	Indian	52:57	arg1	varieties					65:73	Indian paddy varieties	52:73	Indian paddy varieties	52:73	Empirical characterization of hydration behavior of Indian paddy varieties by physicochemical characterization and kinetic studies.
32895940	15	38	theme	paddy	2069:2073	arg1	behavior					2057:2064	the hydration behavior	2043:2064	the hydration behavior of paddy	2043:2073	Knowledge about the hydration behavior of paddy would enable food processors to better understand the effect of process parameters and to model their experimental setup to obtain the desired physicochemical attributes, as well as process yield.
32895940	13	39	theme	paddy	1876:1880	arg1	processing					1882:1891	paddy processing	1876:1891	paddy processing	1876:1891	PRACTICAL APPLICATION: The hydration of paddy is an important procedure in paddy processing, and across the world, many industries are working on it.
32895940	3	40	theme	paddy	458:462	arg1	samples					464:470	the paddy samples	454:470	the paddy samples	454:470	The protein content of the paddy samples was found to be in the range of 6.13 to 9.19%; whereas, starch content was between 67.79 and 84.88%.
32895940	13	41	theme	paddy	1841:1845	arg1	procedure					1863:1871	an important procedure	1850:1871	an important procedure in paddy processing	1850:1891	PRACTICAL APPLICATION: The hydration of paddy is an important procedure in paddy processing, and across the world, many industries are working on it.
32895940	13	41	theme	paddy	1841:1845	arg1	hydration					1828:1836	The hydration	1824:1836	The hydration of paddy	1824:1845	PRACTICAL APPLICATION: The hydration of paddy is an important procedure in paddy processing, and across the world, many industries are working on it.
32895940	2	42	theme	India	372:376	arg1	varieties					359:367	12 different paddy varieties	340:367	12 different paddy varieties of India	340:376	To understand this hydration behavior, the current study analyses the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures.
32895940	2	42	theme	India	372:376	arg1	India					372:376	India	372:376	India	372:376	To understand this hydration behavior, the current study analyses the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures.
32895940	4	43	theme	varieties	614:622	arg1	composition					593:603	The physicochemical composition	573:603	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration	573:676	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
32895940	4	43	theme	varieties	614:622	arg1	decisive					694:701	decisive	694:701	decisive	694:701	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
32895940	15	44	theme	parameters	2147:2156	arg1	effect					2129:2134	the effect	2125:2134	the effect of process parameters	2125:2156	Knowledge about the hydration behavior of paddy would enable food processors to better understand the effect of process parameters and to model their experimental setup to obtain the desired physicochemical attributes, as well as process yield.
32895940	0	45	theme	paddy	59:63	arg1	varieties					65:73	Indian paddy varieties	52:73	Indian paddy varieties	52:73	Empirical characterization of hydration behavior of Indian paddy varieties by physicochemical characterization and kinetic studies.
32895940	10	46	theme	kinetic	1435:1441	arg1	modeling					1443:1450	The kinetic modeling	1431:1450	The kinetic modeling of hydration	1431:1463	The kinetic modeling of hydration was conducted using Peleg's model, with a good fit.
32895940	2	47	theme	varieties	359:367	arg1	kinetics					328:335	the hydration kinetics	314:335	the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures	314:428	To understand this hydration behavior, the current study analyses the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures.
32895940	4	48	from	time-temperature	648:663	arg1	composition					593:603	The physicochemical composition	573:603	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration	573:676	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
32895940	4	48	from	time-temperature	648:663	arg1	decisive					694:701	decisive	694:701	decisive	694:701	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
32895940	2	49	theme	current	291:297	arg1	study					299:303	the current study	287:303	the current study	287:303	To understand this hydration behavior, the current study analyses the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures.
32895940	4	50	from	variation	635:643	arg1	time-temperature					648:663	time-temperature	648:663	time-temperature of hydration	648:676	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
32895940	2	51	theme	hydration	318:326	arg1	kinetics					328:335	the hydration kinetics	314:335	the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures	314:428	To understand this hydration behavior, the current study analyses the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures.
32895940	16	52	theme	processed	2312:2320	arg1	paddy					2322:2326	adequately processed paddy	2301:2326	adequately processed paddy with better digestibility for which industry would have to invest less in terms of time and resources, thereby making the hydrated paddy more affordable	2301:2479	Customers would benefit from adequately processed paddy with better digestibility for which industry would have to invest less in terms of time and resources, thereby making the hydrated paddy more affordable.
32895940	1	53	theme	kinetics	201:208	arg1	determination					174:186	the determination	170:186	the determination of hydration kinetics in paddy	170:217	Temperature is an important factor in the determination of hydration kinetics in paddy, and it varies with variety.
32895940	8	54	theme	optimum	1164:1170	arg1	range					1199:1203	The optimum time-temperature condition range	1160:1203	The optimum time-temperature condition range for hydration for each paddy variety	1160:1240	The optimum time-temperature condition range for hydration for each paddy variety was between 50 and 60°C for 2 to 3.5 hr, depending upon the variety.
32895940	7	55	theme	paddy	1153:1157	arg1	behavior					1141:1148	the hydration behavior	1127:1148	the hydration behavior of paddy	1127:1157	For all samples, the gelatinization temperature was in the range of 65.60 to 83.10 °C, which in turn was negatively correlated with amylose content, and influenced the hydration behavior of paddy.
32895940	3	56	theme	starch	528:533	arg1	content					535:541	starch content	528:541	starch content	528:541	The protein content of the paddy samples was found to be in the range of 6.13 to 9.19%; whereas, starch content was between 67.79 and 84.88%.
32895940	4	57	from	varieties	614:622	arg1	time-temperature					648:663	time-temperature	648:663	time-temperature of hydration	648:676	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
32895940	5	58	theme	higher	838:843	arg1	content					853:859	higher amylose content	838:859	higher amylose content of paddy	838:868	An increased hydration rate was observed with increasing hydration temperature as well as with higher amylose content of paddy.
32895940	8	59	theme	condition	1189:1197	arg1	range					1199:1203	The optimum time-temperature condition range	1160:1203	The optimum time-temperature condition range for hydration for each paddy variety	1160:1240	The optimum time-temperature condition range for hydration for each paddy variety was between 50 and 60°C for 2 to 3.5 hr, depending upon the variety.
32895940	11	60	theme	rate	1665:1668	arg1	K1					1680:1681	K1	1680:1681	K1	1680:1681	The data indicated that with increment in hydration temperature, the rate of hydration was enhanced in all varieties with a decrease in the Peleg's rate constant (K1 ) and capacity constant (K2 ).
32895940	11	60	theme	rate	1665:1668	arg1	constant					1670:1677	the Peleg's rate constant	1653:1677	the Peleg's rate constant (K1 )	1653:1683	The data indicated that with increment in hydration temperature, the rate of hydration was enhanced in all varieties with a decrease in the Peleg's rate constant (K1 ) and capacity constant (K2 ).
32895940	13	61	theme	PRACTICAL	1801:1809	arg1	APPLICATION					1811:1821	PRACTICAL APPLICATION	1801:1821	PRACTICAL APPLICATION: The hydration of paddy is an important procedure in paddy processing, and across the world, many industries are working on it.	1801:1949	PRACTICAL APPLICATION: The hydration of paddy is an important procedure in paddy processing, and across the world, many industries are working on it.
32895940	5	62	theme	hydration	800:808	arg1	temperature					810:820	hydration temperature	800:820	hydration temperature as well as with higher amylose content of paddy	800:868	An increased hydration rate was observed with increasing hydration temperature as well as with higher amylose content of paddy.
32895940	4	63	theme	physicochemical	577:591	arg1	composition					593:603	The physicochemical composition	573:603	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration	573:676	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
32895940	4	63	theme	physicochemical	577:591	arg1	decisive					694:701	decisive	694:701	decisive	694:701	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
32895940	14	64	theme	paddy	1980:1984	arg1	processing					1986:1995	paddy processing	1980:1995	paddy processing	1980:1995	Irrespective of the variety, paddy processing globally has remained tricky.
32895940	15	65	theme	physicochemical	2218:2232	arg1	attributes					2234:2243	the desired physicochemical attributes	2206:2243	the desired physicochemical attributes	2206:2243	Knowledge about the hydration behavior of paddy would enable food processors to better understand the effect of process parameters and to model their experimental setup to obtain the desired physicochemical attributes, as well as process yield.
32895940	14	66	theme	variety	1971:1977	arg1	Irrespective					1951:1962	Irrespective	1951:1962	Irrespective	1951:1962	Irrespective of the variety, paddy processing globally has remained tricky.
32895940	7	67	theme	hydration	1131:1139	arg1	behavior					1141:1148	the hydration behavior	1127:1148	the hydration behavior of paddy	1127:1157	For all samples, the gelatinization temperature was in the range of 65.60 to 83.10 °C, which in turn was negatively correlated with amylose content, and influenced the hydration behavior of paddy.
32895940	7	68	theme	gelatinization	984:997	arg1	temperature					999:1009	the gelatinization temperature	980:1009	the gelatinization temperature	980:1009	For all samples, the gelatinization temperature was in the range of 65.60 to 83.10 °C, which in turn was negatively correlated with amylose content, and influenced the hydration behavior of paddy.
32895940	15	69	theme	process	2257:2263	arg1	yield					2265:2269	process yield	2257:2269	process yield	2257:2269	Knowledge about the hydration behavior of paddy would enable food processors to better understand the effect of process parameters and to model their experimental setup to obtain the desired physicochemical attributes, as well as process yield.
32895940	16	70	theme	affordable	2470:2479	arg1	paddy					2459:2463	the hydrated paddy	2446:2463	the hydrated paddy more affordable	2446:2479	Customers would benefit from adequately processed paddy with better digestibility for which industry would have to invest less in terms of time and resources, thereby making the hydrated paddy more affordable.
32895940	8	71	theme	paddy	1228:1232	arg1	variety					1234:1240	each paddy variety	1223:1240	each paddy variety	1223:1240	The optimum time-temperature condition range for hydration for each paddy variety was between 50 and 60°C for 2 to 3.5 hr, depending upon the variety.
32895940	2	72	theme	hydration	267:275	arg1	behavior					277:284	this hydration behavior	262:284	this hydration behavior	262:284	To understand this hydration behavior, the current study analyses the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures.
32895940	15	73	theme	experimental	2177:2188	arg1	setup					2190:2194	their experimental setup to obtain the desired physicochemical attributes, as well as process yield	2171:2269	their experimental setup to obtain the desired physicochemical attributes, as well as process yield	2171:2269	Knowledge about the hydration behavior of paddy would enable food processors to better understand the effect of process parameters and to model their experimental setup to obtain the desired physicochemical attributes, as well as process yield.
32895940	9	74	theme	8.70	1409:1412	arg1	range					1400:1404	the range	1396:1404	the range of 8.70 to 23.10 kJ/mol	1396:1428	The activation energy for the paddy samples in this investigation was found to be in the range of 8.70 to 23.10 kJ/mol.
32895940	4	75	theme	variation	635:643	arg1	composition					593:603	The physicochemical composition	573:603	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration	573:676	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
32895940	4	75	theme	variation	635:643	arg1	decisive					694:701	decisive	694:701	decisive	694:701	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
32895940	11	76	with	varieties	1624:1632	arg1	decrease					1641:1648	a decrease	1639:1648	a decrease in the Peleg's rate constant (K1 ) and capacity constant (K2 )	1639:1711	The data indicated that with increment in hydration temperature, the rate of hydration was enhanced in all varieties with a decrease in the Peleg's rate constant (K1 ) and capacity constant (K2 ).
32895940	5	77	theme	paddy	864:868	arg1	content					853:859	higher amylose content	838:859	higher amylose content of paddy	838:868	An increased hydration rate was observed with increasing hydration temperature as well as with higher amylose content of paddy.
32895940	5	77	theme	paddy	864:868	arg1	temperature					810:820	hydration temperature	800:820	hydration temperature as well as with higher amylose content of paddy	800:868	An increased hydration rate was observed with increasing hydration temperature as well as with higher amylose content of paddy.
32895940	16	78	theme	time	2411:2414	arg1	terms					2402:2406	terms	2402:2406	terms of time and resources	2402:2428	Customers would benefit from adequately processed paddy with better digestibility for which industry would have to invest less in terms of time and resources, thereby making the hydrated paddy more affordable.
32895940	0	79	theme	kinetic	115:121	arg1	studies					123:129	kinetic studies	115:129	kinetic studies	115:129	Empirical characterization of hydration behavior of Indian paddy varieties by physicochemical characterization and kinetic studies.
32895940	13	80	theme	many	1916:1919	arg1	industries					1921:1930	many industries	1916:1930	many industries	1916:1930	PRACTICAL APPLICATION: The hydration of paddy is an important procedure in paddy processing, and across the world, many industries are working on it.
32895940	12	81	theme	absorption	1780:1789	arg1	temperature-dependence					1748:1769	a direct temperature-dependence	1739:1769	a direct temperature-dependence of water absorption in paddy	1739:1798	These constants indicate a direct temperature-dependence of water absorption in paddy.
32895940	1	82	from	determination	174:186	arg1	paddy					213:217	paddy	213:217	paddy	213:217	Temperature is an important factor in the determination of hydration kinetics in paddy, and it varies with variety.
32895940	16	83	theme	resources	2420:2428	arg1	terms					2402:2406	terms	2402:2406	terms of time and resources	2402:2428	Customers would benefit from adequately processed paddy with better digestibility for which industry would have to invest less in terms of time and resources, thereby making the hydrated paddy more affordable.
32895940	12	84	theme	direct	1741:1746	arg1	temperature-dependence					1748:1769	a direct temperature-dependence	1739:1769	a direct temperature-dependence of water absorption in paddy	1739:1798	These constants indicate a direct temperature-dependence of water absorption in paddy.
32895940	3	85	theme	protein	435:441	arg1	content					443:449	The protein content	431:449	The protein content of the paddy samples	431:470	The protein content of the paddy samples was found to be in the range of 6.13 to 9.19%; whereas, starch content was between 67.79 and 84.88%.
32895940	0	86	theme	hydration	30:38	arg1	behavior					40:47	hydration behavior	30:47	hydration behavior of Indian paddy varieties	30:73	Empirical characterization of hydration behavior of Indian paddy varieties by physicochemical characterization and kinetic studies.
32895940	16	87	with	paddy	2322:2326	arg1	digestibility					2340:2352	better digestibility	2333:2352	better digestibility for which industry would have to invest less in terms of time and resources, thereby making the hydrated paddy more affordable	2333:2479	Customers would benefit from adequately processed paddy with better digestibility for which industry would have to invest less in terms of time and resources, thereby making the hydrated paddy more affordable.
32895940	9	88	from	energy	1326:1331	arg1	investigation					1363:1375	this investigation	1358:1375	this investigation	1358:1375	The activation energy for the paddy samples in this investigation was found to be in the range of 8.70 to 23.10 kJ/mol.
32895940	16	89	theme	better	2333:2338	arg1	digestibility					2340:2352	better digestibility	2333:2352	better digestibility for which industry would have to invest less in terms of time and resources, thereby making the hydrated paddy more affordable	2333:2479	Customers would benefit from adequately processed paddy with better digestibility for which industry would have to invest less in terms of time and resources, thereby making the hydrated paddy more affordable.
32895940	11	90	theme	hydration	1559:1567	arg1	temperature					1569:1579	hydration temperature	1559:1579	hydration temperature	1559:1579	The data indicated that with increment in hydration temperature, the rate of hydration was enhanced in all varieties with a decrease in the Peleg's rate constant (K1 ) and capacity constant (K2 ).
32895940	13	91	theme	important	1853:1861	arg1	procedure					1863:1871	an important procedure	1850:1871	an important procedure in paddy processing	1850:1891	PRACTICAL APPLICATION: The hydration of paddy is an important procedure in paddy processing, and across the world, many industries are working on it.
32895940	13	91	theme	important	1853:1861	arg1	hydration					1828:1836	The hydration	1824:1836	The hydration of paddy	1824:1845	PRACTICAL APPLICATION: The hydration of paddy is an important procedure in paddy processing, and across the world, many industries are working on it.
32895940	2	92	theme	different	399:407	arg1	temperatures					417:428	different soaking temperatures	399:428	different soaking temperatures	399:428	To understand this hydration behavior, the current study analyses the hydration kinetics of 12 different paddy varieties of India that were exposed to different soaking temperatures.
32895940	5	93	theme	hydration	756:764	arg1	rate					766:769	An increased hydration rate	743:769	An increased hydration rate	743:769	An increased hydration rate was observed with increasing hydration temperature as well as with higher amylose content of paddy.
32895940	15	94	theme	food	2088:2091	arg1	processors					2093:2102	food processors	2088:2102	food processors	2088:2102	Knowledge about the hydration behavior of paddy would enable food processors to better understand the effect of process parameters and to model their experimental setup to obtain the desired physicochemical attributes, as well as process yield.
32895940	11	95	theme	hydration	1594:1602	arg1	rate					1586:1589	the rate	1582:1589	the rate of hydration	1582:1602	The data indicated that with increment in hydration temperature, the rate of hydration was enhanced in all varieties with a decrease in the Peleg's rate constant (K1 ) and capacity constant (K2 ).
32895940	11	96	theme	capacity	1689:1696	arg1	constant					1698:1705	capacity constant	1689:1705	capacity constant (K2 )	1689:1711	The data indicated that with increment in hydration temperature, the rate of hydration was enhanced in all varieties with a decrease in the Peleg's rate constant (K1 ) and capacity constant (K2 ).
32895940	11	96	theme	capacity	1689:1696	arg1	K2					1708:1709	K2	1708:1709	K2	1708:1709	The data indicated that with increment in hydration temperature, the rate of hydration was enhanced in all varieties with a decrease in the Peleg's rate constant (K1 ) and capacity constant (K2 ).
32895940	9	97	theme	activation	1315:1324	arg1	energy					1326:1331	The activation energy	1311:1331	The activation energy for the paddy samples in this investigation	1311:1375	The activation energy for the paddy samples in this investigation was found to be in the range of 8.70 to 23.10 kJ/mol.
32895940	4	98	theme	hydration	668:676	arg1	time-temperature					648:663	time-temperature	648:663	time-temperature of hydration	648:676	The physicochemical composition of paddy varieties as well as variation in time-temperature of hydration was found to be decisive in ascertaining the hydration behavior.
34597698	0	0	theme	Volvariella	102:112	arg1	stages					132:137	different Volvariella volvacea maturity stages	92:137	different Volvariella volvacea maturity stages	92:137	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	5	1	theme	VVP	832:834	arg1	I-a					836:838	VVP I-a	832:838	VVP I-a	832:838	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	2	theme	glucan	891:896	arg1	genes					929:933	glucan biosynthesis-associated enzyme genes vvugp and vvgls	891:949	glucan biosynthesis-associated enzyme genes vvugp and vvgls	891:949	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	2	theme	glucan	891:896	arg1	vvgls					945:949	vvgls	945:949	vvgls	945:949	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	2	theme	glucan	891:896	arg1	vvugp					935:939	vvugp	935:939	vvugp	935:939	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	2	3	theme	protein	426:432	arg1	contents					434:441	total soluble carbohydrate and protein contents	395:441	contents	434:441	Elongation and pileus expansion stages decreased total soluble carbohydrate and protein contents to 17.09 mg/g and 8.33 mg/g, and significantly accumulated the total amino acids contents to 32.37 mg/g.
34597698	0	4	theme	different	92:100	arg1	stages					132:137	different Volvariella volvacea maturity stages	92:137	different Volvariella volvacea maturity stages	92:137	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	2	5	theme	total	395:399	arg1	carbohydrate					409:420	total soluble carbohydrate and protein contents	395:441	carbohydrate	409:420	Elongation and pileus expansion stages decreased total soluble carbohydrate and protein contents to 17.09 mg/g and 8.33 mg/g, and significantly accumulated the total amino acids contents to 32.37 mg/g.
34597698	1	6	theme	maturity	173:180	arg1	stage					182:186	maturity stage	173:186	maturity stage	173:186	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	1	7	theme	fruit	311:315	arg1	body					317:320	Volvariella volvacea fruit body	290:320	Volvariella volvacea fruit body	290:320	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	0	8	theme	maturity	123:130	arg1	stages					132:137	different Volvariella volvacea maturity stages	92:137	different Volvariella volvacea maturity stages	92:137	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	0	9	from	Changes	0:6	arg1	stages					132:137	different Volvariella volvacea maturity stages	92:137	different Volvariella volvacea maturity stages	92:137	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	5	10	theme	backbone	1058:1065	arg1	configurations					1112:1125	configurations	1112:1125	configurations	1112:1125	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	10	theme	backbone	1058:1065	arg1	structures					1067:1076	backbone structures	1058:1076	backbone structures including glycosidic linkages and configurations	1058:1125	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	10	theme	backbone	1058:1065	arg1	linkages					1099:1106	glycosidic linkages	1088:1106	glycosidic linkages	1088:1106	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	0	11	theme	volvacea	114:121	arg1	stages					132:137	different Volvariella volvacea maturity stages	92:137	different Volvariella volvacea maturity stages	92:137	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	4	12	dep	VVP	685:687	arg1	I-b					701:703	VVP I-b	697:703	VVP I-b	697:703	Purified VVP I-a and VVP I-b were proved to be α-glucans.
34597698	4	12	dep	VVP	685:687	arg1	VVP					685:687	Purified VVP I-a and VVP I-b	676:703	Purified VVP I-a and VVP I-b	676:703	Purified VVP I-a and VVP I-b were proved to be α-glucans.
34597698	4	12	dep	VVP	685:687	arg1	I-a					689:691	I-a	689:691	I-a	689:691	Purified VVP I-a and VVP I-b were proved to be α-glucans.
34597698	5	13	theme	hydrolysis-associated	972:992	arg1	expression					1016:1025	glucan hydrolysis-associated glucanase gene vvexg2 expression	965:1025	glucan hydrolysis-associated glucanase gene vvexg2 expression	965:1025	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	14	theme	enzyme	922:927	arg1	genes					929:933	glucan biosynthesis-associated enzyme genes vvugp and vvgls	891:949	glucan biosynthesis-associated enzyme genes vvugp and vvgls	891:949	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	14	theme	enzyme	922:927	arg1	vvgls					945:949	vvgls	945:949	vvgls	945:949	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	14	theme	enzyme	922:927	arg1	vvugp					935:939	vvugp	935:939	vvugp	935:939	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	15	theme	gene	1004:1007	arg1	expression					1016:1025	glucan hydrolysis-associated glucanase gene vvexg2 expression	965:1025	glucan hydrolysis-associated glucanase gene vvexg2 expression	965:1025	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	16	theme	biosynthesis-associated	898:920	arg1	genes					929:933	glucan biosynthesis-associated enzyme genes vvugp and vvgls	891:949	glucan biosynthesis-associated enzyme genes vvugp and vvgls	891:949	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	16	theme	biosynthesis-associated	898:920	arg1	vvgls					945:949	vvgls	945:949	vvgls	945:949	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	16	theme	biosynthesis-associated	898:920	arg1	vvugp					935:939	vvugp	935:939	vvugp	935:939	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	1	17	from	effects	162:168	arg1	characteristics					202:216	structural characteristics	191:216	structural characteristics	191:216	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	1	17	from	effects	162:168	arg1	expression					263:272	biosynthesis/hydrolysis-associated genes expression	222:272	biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body	222:320	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	6	18	theme	V.	1192:1193	arg1	structures					1211:1220	V. volvacea glucan structures	1192:1220	V. volvacea glucan structures	1192:1220	The findings would benefit for understanding change patterns of V. volvacea glucan structures and their biosynthesis/hydrolysis-associated genes expression at maturity stages.
34597698	1	19	theme	stage	182:186	arg1	effects					162:168	effects	162:168	effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body	162:320	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	5	20	theme	molecular	811:819	arg1	weights					821:827	the molecular weights	807:827	the molecular weights of VVP I-a and VVP I-b	807:850	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	3	21	theme	egg	616:618	arg1	stage					620:624	egg stage	616:624	egg stage	616:624	Yields of crude polysaccharides significantly increased to 8.12% at egg stage and decreased to 3.72% at pileus expansion stage.
34597698	6	22	theme	structures	1211:1220	arg1	expression					1273:1282	their biosynthesis/hydrolysis-associated genes expression	1226:1282	their biosynthesis/hydrolysis-associated genes expression at maturity stages	1226:1301	The findings would benefit for understanding change patterns of V. volvacea glucan structures and their biosynthesis/hydrolysis-associated genes expression at maturity stages.
34597698	6	22	theme	structures	1211:1220	arg1	patterns					1180:1187	change patterns	1173:1187	change patterns of V. volvacea glucan structures	1173:1220	The findings would benefit for understanding change patterns of V. volvacea glucan structures and their biosynthesis/hydrolysis-associated genes expression at maturity stages.
34597698	6	23	theme	volvacea	1195:1202	arg1	structures					1211:1220	V. volvacea glucan structures	1192:1220	V. volvacea glucan structures	1192:1220	The findings would benefit for understanding change patterns of V. volvacea glucan structures and their biosynthesis/hydrolysis-associated genes expression at maturity stages.
34597698	5	24	theme	decreased	857:865	arg1	levels					881:886	decreased transcription levels	857:886	decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls	857:949	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	25	theme	I-a	836:838	arg1	weights					821:827	the molecular weights	807:827	the molecular weights of VVP I-a and VVP I-b	807:850	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	6	26	theme	glucan	1204:1209	arg1	structures					1211:1220	V. volvacea glucan structures	1192:1220	V. volvacea glucan structures	1192:1220	The findings would benefit for understanding change patterns of V. volvacea glucan structures and their biosynthesis/hydrolysis-associated genes expression at maturity stages.
34597698	1	27	theme	structural	191:200	arg1	characteristics					202:216	structural characteristics	191:216	structural characteristics	191:216	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	5	28	theme	transcription	867:879	arg1	levels					881:886	decreased transcription levels	857:886	decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls	857:949	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	2	29	dep	acids	518:522	arg1	contents					524:531	contents	524:531	the total amino acids contents	502:531	Elongation and pileus expansion stages decreased total soluble carbohydrate and protein contents to 17.09 mg/g and 8.33 mg/g, and significantly accumulated the total amino acids contents to 32.37 mg/g.
34597698	2	30	theme	expansion	368:376	arg1	stages					378:383	pileus expansion stages	361:383	pileus expansion stages	361:383	Elongation and pileus expansion stages decreased total soluble carbohydrate and protein contents to 17.09 mg/g and 8.33 mg/g, and significantly accumulated the total amino acids contents to 32.37 mg/g.
34597698	2	31	theme	amino	512:516	arg1	acids					518:522	the total amino acids	502:522	the total amino acids contents	502:531	Elongation and pileus expansion stages decreased total soluble carbohydrate and protein contents to 17.09 mg/g and 8.33 mg/g, and significantly accumulated the total amino acids contents to 32.37 mg/g.
34597698	1	32	from	body	317:320	arg1	characteristics					202:216	structural characteristics	191:216	structural characteristics	191:216	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	1	32	from	body	317:320	arg1	glucans					277:283	glucans	277:283	glucans from Volvariella volvacea fruit body	277:320	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	1	32	from	body	317:320	arg1	expression					263:272	biosynthesis/hydrolysis-associated genes expression	222:272	biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body	222:320	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	2	33	theme	pileus	361:366	arg1	stages					378:383	pileus expansion stages	361:383	pileus expansion stages	361:383	Elongation and pileus expansion stages decreased total soluble carbohydrate and protein contents to 17.09 mg/g and 8.33 mg/g, and significantly accumulated the total amino acids contents to 32.37 mg/g.
34597698	6	34	from	stages	1296:1301	arg1	expression					1273:1282	their biosynthesis/hydrolysis-associated genes expression	1226:1282	their biosynthesis/hydrolysis-associated genes expression at maturity stages	1226:1301	The findings would benefit for understanding change patterns of V. volvacea glucan structures and their biosynthesis/hydrolysis-associated genes expression at maturity stages.
34597698	6	34	from	stages	1296:1301	arg1	patterns					1180:1187	change patterns	1173:1187	change patterns of V. volvacea glucan structures	1173:1220	The findings would benefit for understanding change patterns of V. volvacea glucan structures and their biosynthesis/hydrolysis-associated genes expression at maturity stages.
34597698	4	35	theme	VVP	697:699	arg1	I-b					701:703	VVP I-b	697:703	VVP I-b	697:703	Purified VVP I-a and VVP I-b were proved to be α-glucans.
34597698	4	35	theme	VVP	697:699	arg1	VVP					685:687	Purified VVP I-a and VVP I-b	676:703	Purified VVP I-a and VVP I-b	676:703	Purified VVP I-a and VVP I-b were proved to be α-glucans.
34597698	0	36	theme	structures	11:20	arg1	Changes					0:6	Changes	0:6	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.	0:138	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	5	37	theme	significant	1035:1045	arg1	effects					1047:1053	no significant effects	1032:1053	no significant effects on backbone structures including glycosidic linkages and configurations	1032:1125	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	38	theme	glucanase	994:1002	arg1	expression					1016:1025	glucan hydrolysis-associated glucanase gene vvexg2 expression	965:1025	glucan hydrolysis-associated glucanase gene vvexg2 expression	965:1025	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	1	39	theme	biosynthesis/hydrolysis-associated	222:255	arg1	expression					263:272	biosynthesis/hydrolysis-associated genes expression	222:272	biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body	222:320	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	0	40	theme	genes	61:65	arg1	expression					67:76	biosynthesis/hydrolysis-associated genes expression	26:76	biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages	26:137	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	5	41	theme	vvexg2	1009:1014	arg1	expression					1016:1025	glucan hydrolysis-associated glucanase gene vvexg2 expression	965:1025	glucan hydrolysis-associated glucanase gene vvexg2 expression	965:1025	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	42	theme	monosaccharide	768:781	arg1	compositions					783:794	the monosaccharide compositions	764:794	the monosaccharide compositions	764:794	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	1	43	dep	Volvariella	290:300	arg1	volvacea					302:309	volvacea	302:309	volvacea	302:309	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	3	44	theme	expansion	659:667	arg1	stage					669:673	pileus expansion stage	652:673	pileus expansion stage	652:673	Yields of crude polysaccharides significantly increased to 8.12% at egg stage and decreased to 3.72% at pileus expansion stage.
34597698	1	45	theme	genes	257:261	arg1	expression					263:272	biosynthesis/hydrolysis-associated genes expression	222:272	biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body	222:320	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	0	46	theme	biosynthesis/hydrolysis-associated	26:59	arg1	expression					67:76	biosynthesis/hydrolysis-associated genes expression	26:76	biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages	26:137	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	5	47	theme	VVP	844:846	arg1	I-b					848:850	VVP I-b	844:850	VVP I-b	844:850	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	6	48	theme	change	1173:1178	arg1	patterns					1180:1187	change patterns	1173:1187	change patterns of V. volvacea glucan structures	1173:1220	The findings would benefit for understanding change patterns of V. volvacea glucan structures and their biosynthesis/hydrolysis-associated genes expression at maturity stages.
34597698	5	49	theme	genes	929:933	arg1	levels					881:886	decreased transcription levels	857:886	decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls	857:949	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	50	theme	I-b	848:850	arg1	weights					821:827	the molecular weights	807:827	the molecular weights of VVP I-a and VVP I-b	807:850	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	1	51	from	expression	263:272	arg1	body					317:320	Volvariella volvacea fruit body	290:320	Volvariella volvacea fruit body	290:320	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	3	52	theme	polysaccharides	564:578	arg1	Yields					548:553	Yields	548:553	Yields of crude polysaccharides	548:578	Yields of crude polysaccharides significantly increased to 8.12% at egg stage and decreased to 3.72% at pileus expansion stage.
34597698	0	53	theme	expression	67:76	arg1	Changes					0:6	Changes	0:6	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.	0:138	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	3	54	theme	pileus	652:657	arg1	stage					669:673	pileus expansion stage	652:673	pileus expansion stage	652:673	Yields of crude polysaccharides significantly increased to 8.12% at egg stage and decreased to 3.72% at pileus expansion stage.
34597698	2	55	theme	soluble	401:407	arg1	carbohydrate					409:420	total soluble carbohydrate and protein contents	395:441	carbohydrate	409:420	Elongation and pileus expansion stages decreased total soluble carbohydrate and protein contents to 17.09 mg/g and 8.33 mg/g, and significantly accumulated the total amino acids contents to 32.37 mg/g.
34597698	5	56	from	effects	1047:1053	arg1	configurations					1112:1125	configurations	1112:1125	configurations	1112:1125	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	56	from	effects	1047:1053	arg1	structures					1067:1076	backbone structures	1058:1076	backbone structures including glycosidic linkages and configurations	1058:1125	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	56	from	effects	1047:1053	arg1	linkages					1099:1106	glycosidic linkages	1088:1106	glycosidic linkages	1088:1106	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	57	theme	maturity	738:745	arg1	process					747:753	The maturity process	734:753	The maturity process	734:753	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	0	58	from	stages	132:137	arg1	structures					11:20	structures	11:20	structures	11:20	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	0	58	from	stages	132:137	arg1	Changes					0:6	Changes	0:6	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.	0:138	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	0	58	from	stages	132:137	arg1	expression					67:76	biosynthesis/hydrolysis-associated genes expression	26:76	biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages	26:137	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	1	59	theme	present	147:153	arg1	study					155:159	the present study	143:159	the present study	143:159	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	6	60	theme	genes	1267:1271	arg1	expression					1273:1282	their biosynthesis/hydrolysis-associated genes expression	1226:1282	their biosynthesis/hydrolysis-associated genes expression at maturity stages	1226:1301	The findings would benefit for understanding change patterns of V. volvacea glucan structures and their biosynthesis/hydrolysis-associated genes expression at maturity stages.
34597698	4	61	theme	Purified	676:683	arg1	I-b					701:703	VVP I-b	697:703	VVP I-b	697:703	Purified VVP I-a and VVP I-b were proved to be α-glucans.
34597698	4	61	theme	Purified	676:683	arg1	VVP					685:687	Purified VVP I-a and VVP I-b	676:703	Purified VVP I-a and VVP I-b	676:703	Purified VVP I-a and VVP I-b were proved to be α-glucans.
34597698	4	61	theme	Purified	676:683	arg1	I-a					689:691	I-a	689:691	I-a	689:691	Purified VVP I-a and VVP I-b were proved to be α-glucans.
34597698	5	62	theme	glycosidic	1088:1097	arg1	linkages					1099:1106	glycosidic linkages	1088:1106	glycosidic linkages	1088:1106	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	63	dep	genes	929:933	arg1	genes					929:933	glucan biosynthesis-associated enzyme genes vvugp and vvgls	891:949	glucan biosynthesis-associated enzyme genes vvugp and vvgls	891:949	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	63	dep	genes	929:933	arg1	vvgls					945:949	vvgls	945:949	vvgls	945:949	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	5	63	dep	genes	929:933	arg1	vvugp					935:939	vvugp	935:939	vvugp	935:939	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	3	64	theme	crude	558:562	arg1	polysaccharides					564:578	crude polysaccharides	558:578	crude polysaccharides	558:578	Yields of crude polysaccharides significantly increased to 8.12% at egg stage and decreased to 3.72% at pileus expansion stage.
34597698	6	65	theme	maturity	1287:1294	arg1	stages					1296:1301	maturity stages	1287:1301	maturity stages	1287:1301	The findings would benefit for understanding change patterns of V. volvacea glucan structures and their biosynthesis/hydrolysis-associated genes expression at maturity stages.
34597698	1	66	theme	glucans	277:283	arg1	characteristics					202:216	structural characteristics	191:216	structural characteristics	191:216	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	1	66	theme	glucans	277:283	arg1	expression					263:272	biosynthesis/hydrolysis-associated genes expression	222:272	biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body	222:320	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	1	67	from	characteristics	202:216	arg1	body					317:320	Volvariella volvacea fruit body	290:320	Volvariella volvacea fruit body	290:320	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
34597698	6	68	theme	biosynthesis/hydrolysis-associated	1232:1265	arg1	expression					1273:1282	their biosynthesis/hydrolysis-associated genes expression	1226:1282	their biosynthesis/hydrolysis-associated genes expression at maturity stages	1226:1301	The findings would benefit for understanding change patterns of V. volvacea glucan structures and their biosynthesis/hydrolysis-associated genes expression at maturity stages.
34597698	0	69	theme	glucans	81:87	arg1	structures					11:20	structures	11:20	structures	11:20	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	0	69	theme	glucans	81:87	arg1	expression					67:76	biosynthesis/hydrolysis-associated genes expression	26:76	biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages	26:137	Changes of structures and biosynthesis/hydrolysis-associated genes expression of glucans at different Volvariella volvacea maturity stages.
34597698	2	70	theme	total	506:510	arg1	acids					518:522	the total amino acids	502:522	the total amino acids contents	502:531	Elongation and pileus expansion stages decreased total soluble carbohydrate and protein contents to 17.09 mg/g and 8.33 mg/g, and significantly accumulated the total amino acids contents to 32.37 mg/g.
34597698	5	71	theme	glucan	965:970	arg1	expression					1016:1025	glucan hydrolysis-associated glucanase gene vvexg2 expression	965:1025	glucan hydrolysis-associated glucanase gene vvexg2 expression	965:1025	The maturity process affected the monosaccharide compositions, decreased the molecular weights of VVP I-a and VVP I-b with decreased transcription levels of glucan biosynthesis-associated enzyme genes vvugp and vvgls and increased glucan hydrolysis-associated glucanase gene vvexg2 expression with no significant effects on backbone structures including glycosidic linkages and configurations.
34597698	1	72	theme	Volvariella	290:300	arg1	body					317:320	Volvariella volvacea fruit body	290:320	Volvariella volvacea fruit body	290:320	In the present study, effects of maturity stage on structural characteristics and biosynthesis/hydrolysis-associated genes expression of glucans from Volvariella volvacea fruit body were well investigated.
32787276	0	0	theme	Controlled	128:137	arg1	Release					150:156	Controlled Antibiotic Release	128:156	Controlled Antibiotic Release	128:156	Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release.
32787276	2	1	theme	cross-linkers	483:495	arg1	use					448:450	the use	444:450	the use of toxic spinning solvents and cross-linkers	444:495	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	1	theme	cross-linkers	483:495	arg1	capacity					520:527	moderate water regain capacity	498:527	moderate water regain capacity	498:527	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	1	theme	cross-linkers	483:495	arg1	lack					534:537	lack	534:537	lack of triggered release function	534:567	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	5	2	used	utilized	1299:1306	arg2	scaffolds					1318:1326	tissue scaffolds	1311:1326	tissue scaffolds	1311:1326	These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.
32787276	5	2	used	utilized	1299:1306	arg2	systems					1285:1291	the new NFM systems	1273:1291	the new NFM systems	1273:1291	These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.
32787276	3	3	theme	N-maleoyl-functional	752:771	arg1	MCS					783:785	MCS	783:785	MCS	783:785	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	3	theme	N-maleoyl-functional	752:771	arg1	chitosan					773:780	highly swelling cross-linked N-maleoyl-functional chitosan	723:780	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	1	4	theme	composited	260:269	arg1	NFMs					289:292	NFMs	289:292	NFMs	289:292	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	1	4	theme	composited	260:269	arg1	meshes					281:286	CS/PEO composited nanofiber meshes	253:286	CS/PEO composited nanofiber meshes (NFMs)	253:293	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	1	4	theme	composited	260:269	arg1	dressings					339:347	wound healing dressings	325:347	wound healing dressings for skin tissue regeneration	325:376	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	4	5	theme	NFM	1112:1114	arg1	system					1116:1121	this new NFM system	1103:1121	this new NFM system	1103:1121	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	1	6	used	used	317:320	arg2	NFMs					289:292	NFMs	289:292	NFMs	289:292	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	1	6	used	used	317:320	arg2	meshes					281:286	CS/PEO composited nanofiber meshes	253:286	CS/PEO composited nanofiber meshes (NFMs)	253:293	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	1	6	used	used	317:320	arg2	dressings					339:347	wound healing dressings	325:347	wound healing dressings for skin tissue regeneration	325:376	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	4	7	theme	enhanced	1132:1139	arg1	capability					1150:1159	enhanced swelling capability	1132:1159	enhanced swelling capability	1132:1159	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	1	8	theme	nanofiber	271:279	arg1	NFMs					289:292	NFMs	289:292	NFMs	289:292	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	1	8	theme	nanofiber	271:279	arg1	meshes					281:286	CS/PEO composited nanofiber meshes	253:286	CS/PEO composited nanofiber meshes (NFMs)	253:293	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	1	8	theme	nanofiber	271:279	arg1	dressings					339:347	wound healing dressings	325:347	wound healing dressings for skin tissue regeneration	325:376	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	4	9	theme	simultaneous	1009:1020	arg1	introduction					1022:1033	the simultaneous introduction	1005:1033	the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages	1005:1100	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	1	10	theme	skin	353:356	arg1	regeneration					365:376	skin tissue regeneration	353:376	skin tissue regeneration	353:376	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	2	11	theme	biomedical	598:607	arg1	applications					609:620	their biomedical applications	592:620	their biomedical applications	592:620	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	3	12	theme	UV-irradiated	909:921	arg1	NFMs					792:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	12	theme	UV-irradiated	909:921	arg1	treatment					936:944	a UV-irradiated cross-linked treatment	907:944	a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers	907:997	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	13	theme	NFM	847:849	arg1	system					851:856	the next-generation CS/PEO NFM system	820:856	the next-generation CS/PEO NFM system through an acid-free electrospinning process	820:901	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	13	theme	NFM	847:849	arg1	NFMs					792:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	0	14	theme	Antibiotic	139:148	arg1	Release					150:156	Controlled Antibiotic Release	128:156	Controlled Antibiotic Release	128:156	Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release.
32787276	1	15	theme	tissue	358:363	arg1	regeneration					365:376	skin tissue regeneration	353:376	skin tissue regeneration	353:376	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	3	16	theme	aldehyde-containing	965:983	arg1	cross-linkers					985:997	aldehyde-containing cross-linkers	965:997	aldehyde-containing cross-linkers	965:997	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	4	17	theme	disulfide	1064:1072	arg1	bonds					1074:1078	disulfide bonds	1064:1078	disulfide bonds	1064:1078	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	3	18	theme	chitosan	773:780	arg1	system					851:856	the next-generation CS/PEO NFM system	820:856	the next-generation CS/PEO NFM system through an acid-free electrospinning process	820:901	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	18	theme	chitosan	773:780	arg1	NFMs					792:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	18	theme	chitosan	773:780	arg1	treatment					936:944	a UV-irradiated cross-linked treatment	907:944	a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers	907:997	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	2	19	theme	NFM	425:427	arg1	system					429:434	the NFM system	421:434	the NFM system	421:434	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	3	20	link	cross-linked	739:750	arg1	MCS					783:785	MCS	783:785	MCS	783:785	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	20	link	cross-linked	739:750	arg1	chitosan					773:780	highly swelling cross-linked N-maleoyl-functional chitosan	723:780	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	2	21	theme	water	507:511	arg1	capacity					520:527	moderate water regain capacity	498:527	moderate water regain capacity	498:527	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	3	22	theme	swelling	730:737	arg1	MCS					783:785	MCS	783:785	MCS	783:785	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	22	theme	swelling	730:737	arg1	chitosan					773:780	highly swelling cross-linked N-maleoyl-functional chitosan	723:780	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	2	23	theme	solvents	470:477	arg1	use					448:450	the use	444:450	the use of toxic spinning solvents and cross-linkers	444:495	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	23	theme	solvents	470:477	arg1	capacity					520:527	moderate water regain capacity	498:527	moderate water regain capacity	498:527	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	23	theme	solvents	470:477	arg1	lack					534:537	lack	534:537	lack of triggered release function	534:567	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	5	24	theme	healing	1361:1367	arg1	dressings					1369:1377	functional wound healing dressings	1344:1377	functional wound healing dressings	1344:1377	These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.
32787276	4	25	theme	high	1219:1222	arg1	biocompatibility					1224:1239	high biocompatibility	1219:1239	high biocompatibility	1219:1239	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	2	26	theme	innate	401:406	arg1	use					448:450	the use	444:450	the use of toxic spinning solvents and cross-linkers	444:495	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	26	theme	innate	401:406	arg1	drawbacks					408:416	numerous innate drawbacks	392:416	numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function	392:567	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	26	theme	innate	401:406	arg1	capacity					520:527	moderate water regain capacity	498:527	moderate water regain capacity	498:527	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	26	theme	innate	401:406	arg1	lack					534:537	lack	534:537	lack of triggered release function	534:567	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	4	27	theme	oxide	1047:1051	arg1	chains					1053:1058	ethylene oxide chains	1038:1058	ethylene oxide chains	1038:1058	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	3	28	theme	cross-linked	739:750	arg1	MCS					783:785	MCS	783:785	MCS	783:785	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	28	theme	cross-linked	739:750	arg1	chitosan					773:780	highly swelling cross-linked N-maleoyl-functional chitosan	723:780	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	2	29	theme	moderate	498:505	arg1	capacity					520:527	moderate water regain capacity	498:527	moderate water regain capacity	498:527	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	30	theme	numerous	392:399	arg1	use					448:450	the use	444:450	the use of toxic spinning solvents and cross-linkers	444:495	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	30	theme	numerous	392:399	arg1	drawbacks					408:416	numerous innate drawbacks	392:416	numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function	392:567	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	30	theme	numerous	392:399	arg1	capacity					520:527	moderate water regain capacity	498:527	moderate water regain capacity	498:527	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	30	theme	numerous	392:399	arg1	lack					534:537	lack	534:537	lack of triggered release function	534:567	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	3	31	theme	bacterial	702:710	arg1	infection					712:720	bacterial infection	702:720	bacterial infection	702:720	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	5	32	theme	NFM	1281:1283	arg1	systems					1285:1291	the new NFM systems	1273:1291	the new NFM systems	1273:1291	These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.
32787276	5	32	theme	NFM	1281:1283	arg1	scaffolds					1318:1326	tissue scaffolds	1311:1326	tissue scaffolds	1311:1326	These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.
32787276	4	33	from	introduction	1022:1033	arg1	cross-linkages					1087:1100	the cross-linkages	1083:1100	the cross-linkages	1083:1100	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	0	34	theme	Swelling/Antibacterial	22:43	arg1	Meshes					117:122	Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes	15:122	Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes	15:122	Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release.
32787276	3	35	theme	/PEO	787:790	arg1	system					851:856	the next-generation CS/PEO NFM system	820:856	the next-generation CS/PEO NFM system through an acid-free electrospinning process	820:901	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	35	theme	/PEO	787:790	arg1	NFMs					792:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	35	theme	/PEO	787:790	arg1	treatment					936:944	a UV-irradiated cross-linked treatment	907:944	a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers	907:997	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	2	36	theme	triggered	542:550	arg1	function					560:567	triggered release function	542:567	triggered release function	542:567	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	4	37	theme	bonds	1074:1078	arg1	introduction					1022:1033	the simultaneous introduction	1005:1033	the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages	1005:1100	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	2	38	theme	system	429:434	arg1	use					448:450	the use	444:450	the use of toxic spinning solvents and cross-linkers	444:495	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	38	theme	system	429:434	arg1	drawbacks					408:416	numerous innate drawbacks	392:416	numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function	392:567	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	38	theme	system	429:434	arg1	capacity					520:527	moderate water regain capacity	498:527	moderate water regain capacity	498:527	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	38	theme	system	429:434	arg1	lack					534:537	lack	534:537	lack of triggered release function	534:567	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	4	39	theme	triggered	1185:1193	arg1	release					1206:1212	triggered antibiotic release	1185:1212	triggered antibiotic release	1185:1212	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	2	40	theme	toxic	455:459	arg1	solvents					470:477	toxic spinning solvents	455:477	toxic spinning solvents	455:477	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	1	41	theme	polyethylene	227:238	arg1	PEO					247:249	PEO	247:249	PEO	247:249	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	1	41	theme	polyethylene	227:238	arg1	oxide					240:244	polyethylene oxide	227:244	polyethylene oxide (PEO)	227:250	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	0	42	theme	N-Maleoyl-Functional	58:77	arg1	Meshes					117:122	Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes	15:122	Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes	15:122	Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release.
32787276	5	43	theme	new	1277:1279	arg1	systems					1285:1291	the new NFM systems	1273:1291	the new NFM systems	1273:1291	These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.
32787276	5	43	theme	new	1277:1279	arg1	scaffolds					1318:1326	tissue scaffolds	1311:1326	tissue scaffolds	1311:1326	These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.
32787276	3	44	theme	cross-linkers	985:997	arg1	use					958:960	the use	954:960	the use of aldehyde-containing cross-linkers	954:997	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	1	45	theme	oxide	240:244	arg1	affinity					175:182	the cell affinity	166:182	the cell affinity of chitosan (CS)	166:199	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	1	45	theme	oxide	240:244	arg1	hydrophilicity					209:222	the hydrophilicity	205:222	the hydrophilicity of polyethylene oxide (PEO)	205:250	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	0	46	theme	Cross-Linked	45:56	arg1	Meshes					117:122	Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes	15:122	Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes	15:122	Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release.
32787276	4	47	theme	chains	1053:1058	arg1	introduction					1022:1033	the simultaneous introduction	1005:1033	the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages	1005:1100	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	2	48	theme	spinning	461:468	arg1	solvents					470:477	toxic spinning solvents	455:477	toxic spinning solvents	455:477	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	3	49	link	cross-linked	923:934	arg1	NFMs					792:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	49	link	cross-linked	923:934	arg1	treatment					936:944	a UV-irradiated cross-linked treatment	907:944	a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers	907:997	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	4	50	theme	antibacterial	1162:1174	arg1	ability					1176:1182	antibacterial ability	1162:1182	antibacterial ability	1162:1182	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	5	51	theme	biomedical	1248:1257	arg1	merits					1259:1264	These biomedical merits	1242:1264	These biomedical merits	1242:1264	These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.
32787276	0	52	theme	Oxide	101:105	arg1	Meshes					117:122	Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes	15:122	Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes	15:122	Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release.
32787276	4	53	theme	ethylene	1038:1045	arg1	oxide					1047:1051	ethylene oxide	1038:1051	ethylene oxide chains	1038:1058	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	4	54	theme	antibiotic	1195:1204	arg1	release					1206:1212	triggered antibiotic release	1185:1212	triggered antibiotic release	1185:1212	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	0	55	theme	Chitosan/Polyethylene	79:99	arg1	Meshes					117:122	Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes	15:122	Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes	15:122	Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release.
32787276	5	56	theme	wound	1355:1359	arg1	healing					1361:1367	functional wound healing	1344:1367	functional wound healing dressings	1344:1377	These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.
32787276	1	57	theme	wound	325:329	arg1	healing					331:337	wound healing	325:337	wound healing dressings for skin tissue regeneration	325:376	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	2	58	theme	function	560:567	arg1	use					448:450	the use	444:450	the use of toxic spinning solvents and cross-linkers	444:495	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	58	theme	function	560:567	arg1	capacity					520:527	moderate water regain capacity	498:527	moderate water regain capacity	498:527	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	2	58	theme	function	560:567	arg1	lack					534:537	lack	534:537	lack of triggered release function	534:567	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	1	59	theme	cell	170:173	arg1	affinity					175:182	the cell affinity	166:182	the cell affinity of chitosan (CS)	166:199	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	4	60	theme	swelling	1141:1148	arg1	capability					1150:1159	enhanced swelling capability	1132:1159	enhanced swelling capability	1132:1159	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	3	61	theme	next-generation	824:838	arg1	system					851:856	the next-generation CS/PEO NFM system	820:856	the next-generation CS/PEO NFM system through an acid-free electrospinning process	820:901	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	61	theme	next-generation	824:838	arg1	NFMs					792:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	2	62	theme	release	552:558	arg1	function					560:567	triggered release function	542:567	triggered release function	542:567	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	3	63	theme	cell	675:678	arg1	growth					680:685	cell growth	675:685	cell growth	675:685	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	2	64	dep	capacity	520:527	arg1	regain					513:518	regain	513:518	regain	513:518	Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications.
32787276	3	65	theme	acid-free	869:877	arg1	process					895:901	an acid-free electrospinning process	866:901	an acid-free electrospinning process	866:901	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	66	theme	CS/PEO	840:845	arg1	system					851:856	the next-generation CS/PEO NFM system	820:856	the next-generation CS/PEO NFM system through an acid-free electrospinning process	820:901	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	66	theme	CS/PEO	840:845	arg1	NFMs					792:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	0	67	theme	Meshes	117:122	arg1	Preparation					0:10	Preparation	0:10	Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release.	0:157	Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release.
32787276	5	68	theme	functional	1344:1353	arg1	healing					1361:1367	functional wound healing	1344:1367	functional wound healing dressings	1344:1377	These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.
32787276	3	69	theme	electrospinning	879:893	arg1	process					895:901	an acid-free electrospinning process	866:901	an acid-free electrospinning process	866:901	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	5	70	theme	tissue	1311:1316	arg1	systems					1285:1291	the new NFM systems	1273:1291	the new NFM systems	1273:1291	These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.
32787276	5	70	theme	tissue	1311:1316	arg1	scaffolds					1318:1326	tissue scaffolds	1311:1326	tissue scaffolds	1311:1326	These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.
32787276	0	71	theme	Nanofiber	107:115	arg1	Meshes					117:122	Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes	15:122	Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes	15:122	Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release.
32787276	1	72	theme	healing	331:337	arg1	meshes					281:286	CS/PEO composited nanofiber meshes	253:286	CS/PEO composited nanofiber meshes (NFMs)	253:293	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	1	72	theme	healing	331:337	arg1	dressings					339:347	wound healing dressings	325:347	wound healing dressings for skin tissue regeneration	325:376	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	4	73	theme	new	1108:1110	arg1	system					1116:1121	this new NFM system	1103:1121	this new NFM system	1103:1121	With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility.
32787276	1	74	theme	chitosan	187:194	arg1	affinity					175:182	the cell affinity	166:182	the cell affinity of chitosan (CS)	166:199	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	1	74	theme	chitosan	187:194	arg1	hydrophilicity					209:222	the hydrophilicity	205:222	the hydrophilicity of polyethylene oxide (PEO)	205:250	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	3	75	theme	cross-linked	923:934	arg1	NFMs					792:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs	723:795	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	3	75	theme	cross-linked	923:934	arg1	treatment					936:944	a UV-irradiated cross-linked treatment	907:944	a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers	907:997	In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers.
32787276	1	76	theme	CS/PEO	253:258	arg1	NFMs					289:292	NFMs	289:292	NFMs	289:292	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	1	76	theme	CS/PEO	253:258	arg1	meshes					281:286	CS/PEO composited nanofiber meshes	253:286	CS/PEO composited nanofiber meshes (NFMs)	253:293	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
32787276	1	76	theme	CS/PEO	253:258	arg1	dressings					339:347	wound healing dressings	325:347	wound healing dressings for skin tissue regeneration	325:376	Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration.
34894199	10	0	from	elderly	1648:1654	arg1	treatment					1619:1627	the treatment	1615:1627	the treatment of diabetes in the elderly	1615:1654	CONCLUSIONS These results suggest that EPO could be a potential novel natural drug for the treatment of diabetes in the elderly.
34894199	7	1	theme	c-Jun	1051:1055	arg1	JNK					1076:1078	JNK	1076:1078	JNK	1076:1078	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	1	theme	c-Jun	1051:1055	arg1	Kinase					1068:1073	the c-Jun N-terminal Kinase	1047:1073	the c-Jun N-terminal Kinase (JNK)	1047:1079	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	2	from	Kinase	1068:1073	arg1	intestine					1115:1123	the intestine to regulate glucose metabolite status and ageing in mice	1111:1180	the intestine to regulate glucose metabolite status and ageing in mice	1111:1180	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	2	from	Kinase	1068:1073	arg1	brain					1037:1041	the brain	1033:1041	the brain	1033:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	3	dep	Activator	942:950	arg1	axis					1103:1106	/FOXO1/Bcl-6 signaling axis	1080:1106	/FOXO1/Bcl-6 signaling axis	1080:1106	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	2	4	theme	brain	389:393	arg1	metabolites					395:405	the brain metabolites	385:405	the brain metabolites	385:405	METHODS AND RESULTS LC-MS metabolomics and 16S rRNA sequencing is used to identify the brain metabolites and gut microbiota, respectively.
34894199	9	5	from	species	1495:1501	arg1	diabetes					1518:1525	age-related diabetes	1506:1525	age-related diabetes	1506:1525	Enterococcus is negatively correlated with AMP in the brain and could be a potential hallmark species in age-related diabetes.
34894199	8	6	theme	type	1242:1245	arg1	expression					1256:1265	glucagon-like peptide type 1 (GLP1) expression	1220:1265	glucagon-like peptide type 1 (GLP1) expression	1220:1265	EPO could also improve the levels of glucagon-like peptide type 1 (GLP1) expression in the gut, thereby inducing high expression of GLP1 receptor in the brain to control glucose metabolites through the brain-gut axis.
34894199	2	7	theme	RESULTS	314:320	arg1	metabolomics					328:339	METHODS AND RESULTS LC-MS metabolomics	302:339	METHODS AND RESULTS LC-MS metabolomics	302:339	METHODS AND RESULTS LC-MS metabolomics and 16S rRNA sequencing is used to identify the brain metabolites and gut microbiota, respectively.
34894199	7	8	theme	signaling	1093:1101	arg1	axis					1103:1106	/FOXO1/Bcl-6 signaling axis	1080:1106	/FOXO1/Bcl-6 signaling axis	1080:1106	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	1	9	theme	prolifera	219:227	arg1	EPO					246:248	EPO	246:248	EPO	246:248	SCOPE To investigate the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice.
34894199	1	9	theme	prolifera	219:227	arg1	oligosaccharide					229:243	Enteromorpha prolifera oligosaccharide	206:243	Enteromorpha prolifera oligosaccharide (EPO)	206:249	SCOPE To investigate the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice.
34894199	6	10	dep	composition	843:853	arg1	the					839:841	the	839:841	the	839:841	Additionally, EPO could alter the composition and diversity of gut microbiota in mice.
34894199	7	11	from	pathways	1021:1028	arg1	brain					1037:1041	the brain	1033:1041	the brain	1033:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	5	12	theme	daf-16	746:751	arg1	expressions					724:734	the relative expressions	711:734	the relative expressions of daf-2, daf-16, and skn-1 in insulin-resistant Caenorhabditis elegans	711:806	Inosine is found to enhance the relative expressions of daf-2, daf-16, and skn-1 in insulin-resistant Caenorhabditis elegans.
34894199	2	13	theme	16S	345:347	arg1	sequencing					354:363	16S rRNA sequencing	345:363	16S rRNA sequencing	345:363	METHODS AND RESULTS LC-MS metabolomics and 16S rRNA sequencing is used to identify the brain metabolites and gut microbiota, respectively.
34894199	8	14	theme	glucagon-like	1220:1232	arg1	type					1242:1245	glucagon-like peptide type 1	1220:1247	glucagon-like peptide type 1 (GLP1) expression	1220:1265	EPO could also improve the levels of glucagon-like peptide type 1 (GLP1) expression in the gut, thereby inducing high expression of GLP1 receptor in the brain to control glucose metabolites through the brain-gut axis.
34894199	8	14	theme	glucagon-like	1220:1232	arg1	GLP1					1250:1253	GLP1	1250:1253	GLP1	1250:1253	EPO could also improve the levels of glucagon-like peptide type 1 (GLP1) expression in the gut, thereby inducing high expression of GLP1 receptor in the brain to control glucose metabolites through the brain-gut axis.
34894199	10	15	theme	novel	1592:1596	arg1	drug					1606:1609	a potential novel natural drug	1580:1609	a potential novel natural drug for the treatment of diabetes in the elderly	1580:1654	CONCLUSIONS These results suggest that EPO could be a potential novel natural drug for the treatment of diabetes in the elderly.
34894199	10	15	theme	novel	1592:1596	arg1	EPO					1567:1569	EPO	1567:1569	EPO	1567:1569	CONCLUSIONS These results suggest that EPO could be a potential novel natural drug for the treatment of diabetes in the elderly.
34894199	7	16	theme	N-terminal	1057:1066	arg1	JNK					1076:1078	JNK	1076:1078	JNK	1076:1078	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	16	theme	N-terminal	1057:1066	arg1	Kinase					1068:1073	the c-Jun N-terminal Kinase	1047:1073	the c-Jun N-terminal Kinase (JNK)	1047:1079	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	17	theme	pathways	1021:1028	arg1	Transducer					927:936	the Signal Transducer	916:936	the Signal Transducer	916:936	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	17	theme	pathways	1021:1028	arg1	JNK					1076:1078	JNK	1076:1078	JNK	1076:1078	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	17	theme	pathways	1021:1028	arg1	Kinase					1068:1073	the c-Jun N-terminal Kinase	1047:1073	the c-Jun N-terminal Kinase (JNK)	1047:1079	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	17	theme	pathways	1021:1028	arg1	Activator					942:950	Activator	942:950	Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain	942:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	5	18	theme	daf-2	739:743	arg1	expressions					724:734	the relative expressions	711:734	the relative expressions of daf-2, daf-16, and skn-1 in insulin-resistant Caenorhabditis elegans	711:806	Inosine is found to enhance the relative expressions of daf-2, daf-16, and skn-1 in insulin-resistant Caenorhabditis elegans.
34894199	2	19	theme	METHODS	302:308	arg1	metabolomics					328:339	METHODS AND RESULTS LC-MS metabolomics	302:339	METHODS AND RESULTS LC-MS metabolomics	302:339	METHODS AND RESULTS LC-MS metabolomics and 16S rRNA sequencing is used to identify the brain metabolites and gut microbiota, respectively.
34894199	9	20	theme	potential	1476:1484	arg1	species					1495:1501	a potential hallmark species	1474:1501	a potential hallmark species in age-related diabetes	1474:1525	Enterococcus is negatively correlated with AMP in the brain and could be a potential hallmark species in age-related diabetes.
34894199	8	21	theme	high	1296:1299	arg1	expression					1301:1310	high expression	1296:1310	high expression of GLP1 receptor	1296:1327	EPO could also improve the levels of glucagon-like peptide type 1 (GLP1) expression in the gut, thereby inducing high expression of GLP1 receptor in the brain to control glucose metabolites through the brain-gut axis.
34894199	1	22	from	effects	195:201	arg1	mice					296:299	age-matched streptozocin-induced diabetic mice	254:299	age-matched streptozocin-induced diabetic mice	254:299	SCOPE To investigate the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice.
34894199	1	23	theme	anti-ageing	165:175	arg1	effects					195:201	the anti-ageing and anti-diabetic effects	161:201	the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice	161:299	SCOPE To investigate the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice.
34894199	10	24	dep	CONCLUSIONS	1528:1538	arg1	suggest					1554:1560	suggest	1554:1560	suggest that EPO could be a potential novel natural drug for the treatment of diabetes in the elderly	1554:1654	CONCLUSIONS These results suggest that EPO could be a potential novel natural drug for the treatment of diabetes in the elderly.
34894199	0	25	theme	Gut-Brain	95:103	arg1	Axis					105:108	Gut-Brain Axis	95:108	Gut-Brain Axis in Age-Matched Diabetic Mice	95:137	Green Alga Enteromorpha prolifera Oligosaccharide Ameliorates Ageing and Hyperglycemia through Gut-Brain Axis in Age-Matched Diabetic Mice.
34894199	7	26	theme	cell	997:1000	arg1	Bcl-6					1014:1018	Bcl-6	1014:1018	Bcl-6	1014:1018	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	26	theme	cell	997:1000	arg1	lymphoma					1002:1009	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6	955:1011	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain	955:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	1	27	theme	anti-diabetic	181:193	arg1	effects					195:201	the anti-ageing and anti-diabetic effects	161:201	the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice	161:299	SCOPE To investigate the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice.
34894199	8	28	theme	receptor	1320:1327	arg1	expression					1301:1310	high expression	1296:1310	high expression of GLP1 receptor	1296:1327	EPO could also improve the levels of glucagon-like peptide type 1 (GLP1) expression in the gut, thereby inducing high expression of GLP1 receptor in the brain to control glucose metabolites through the brain-gut axis.
34894199	7	29	from	Transducer	927:936	arg1	intestine					1115:1123	the intestine to regulate glucose metabolite status and ageing in mice	1111:1180	the intestine to regulate glucose metabolite status and ageing in mice	1111:1180	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	29	from	Transducer	927:936	arg1	brain					1037:1041	the brain	1033:1041	the brain	1033:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	10	30	theme	diabetes	1632:1639	arg1	treatment					1619:1627	the treatment	1615:1627	the treatment of diabetes in the elderly	1615:1654	CONCLUSIONS These results suggest that EPO could be a potential novel natural drug for the treatment of diabetes in the elderly.
34894199	5	31	theme	Caenorhabditis	785:798	arg1	elegans					800:806	insulin-resistant Caenorhabditis elegans	767:806	insulin-resistant Caenorhabditis elegans	767:806	Inosine is found to enhance the relative expressions of daf-2, daf-16, and skn-1 in insulin-resistant Caenorhabditis elegans.
34894199	6	32	from	composition	843:853	arg1	mice					890:893	mice	890:893	mice	890:893	Additionally, EPO could alter the composition and diversity of gut microbiota in mice.
34894199	7	33	from	Activator	942:950	arg1	intestine					1115:1123	the intestine to regulate glucose metabolite status and ageing in mice	1111:1180	the intestine to regulate glucose metabolite status and ageing in mice	1111:1180	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	33	from	Activator	942:950	arg1	brain					1037:1041	the brain	1033:1041	the brain	1033:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	3	34	theme	glucose	473:479	arg1	metabolism					481:490	glucose metabolism	473:490	glucose metabolism	473:490	EPO could significantly improve glucose metabolism and activity of total superoxide dismutase in serum.
34894199	0	35	theme	Green	0:4	arg1	Oligosaccharide					34:48	Green Alga Enteromorpha prolifera Oligosaccharide	0:48	Green Alga Enteromorpha prolifera Oligosaccharide	0:48	Green Alga Enteromorpha prolifera Oligosaccharide Ameliorates Ageing and Hyperglycemia through Gut-Brain Axis in Age-Matched Diabetic Mice.
34894199	7	36	theme	Box	980:982	arg1	Bcl-6					1014:1018	Bcl-6	1014:1018	Bcl-6	1014:1018	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	36	theme	Box	980:982	arg1	lymphoma					1002:1009	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6	955:1011	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain	955:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	6	37	from	diversity	859:867	arg1	mice					890:893	mice	890:893	mice	890:893	Additionally, EPO could alter the composition and diversity of gut microbiota in mice.
34894199	8	38	theme	glucose	1353:1359	arg1	metabolites					1361:1371	glucose metabolites	1353:1371	glucose metabolites	1353:1371	EPO could also improve the levels of glucagon-like peptide type 1 (GLP1) expression in the gut, thereby inducing high expression of GLP1 receptor in the brain to control glucose metabolites through the brain-gut axis.
34894199	3	39	theme	superoxide	514:523	arg1	dismutase					525:533	total superoxide dismutase	508:533	total superoxide dismutase	508:533	EPO could significantly improve glucose metabolism and activity of total superoxide dismutase in serum.
34894199	0	40	theme	Enteromorpha	11:22	arg1	Oligosaccharide					34:48	Green Alga Enteromorpha prolifera Oligosaccharide	0:48	Green Alga Enteromorpha prolifera Oligosaccharide	0:48	Green Alga Enteromorpha prolifera Oligosaccharide Ameliorates Ageing and Hyperglycemia through Gut-Brain Axis in Age-Matched Diabetic Mice.
34894199	10	41	from	treatment	1619:1627	arg1	elderly					1648:1654	elderly	1648:1654	elderly	1648:1654	CONCLUSIONS These results suggest that EPO could be a potential novel natural drug for the treatment of diabetes in the elderly.
34894199	4	42	theme	tricarboxylic	572:584	arg1	cycle					591:595	the tricarboxylic acid cycle	568:595	the tricarboxylic acid cycle	568:595	It also could regulate the tricarboxylic acid cycle, arginine, and inosine-related metabolic pathways in the brain of aged diabetic mice.
34894199	8	43	theme	brain-gut	1385:1393	arg1	axis					1395:1398	the brain-gut axis	1381:1398	the brain-gut axis	1381:1398	EPO could also improve the levels of glucagon-like peptide type 1 (GLP1) expression in the gut, thereby inducing high expression of GLP1 receptor in the brain to control glucose metabolites through the brain-gut axis.
34894199	7	44	theme	metabolite	1145:1154	arg1	status					1156:1161	glucose metabolite status	1137:1161	glucose metabolite status	1137:1161	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	10	45	from	diabetes	1632:1639	arg1	elderly					1648:1654	elderly	1648:1654	elderly	1648:1654	CONCLUSIONS These results suggest that EPO could be a potential novel natural drug for the treatment of diabetes in the elderly.
34894199	7	46	theme	3/Forkhead	969:978	arg1	Bcl-6					1014:1018	Bcl-6	1014:1018	Bcl-6	1014:1018	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	46	theme	3/Forkhead	969:978	arg1	lymphoma					1002:1009	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6	955:1011	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain	955:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	6	47	theme	microbiota	876:885	arg1	diversity					859:867	diversity	859:867	diversity	859:867	Additionally, EPO could alter the composition and diversity of gut microbiota in mice.
34894199	6	47	theme	microbiota	876:885	arg1	composition					843:853	composition	843:853	composition	843:853	Additionally, EPO could alter the composition and diversity of gut microbiota in mice.
34894199	3	48	theme	total	508:512	arg1	dismutase					525:533	total superoxide dismutase	508:533	total superoxide dismutase	508:533	EPO could significantly improve glucose metabolism and activity of total superoxide dismutase in serum.
34894199	3	49	from	metabolism	481:490	arg1	serum					538:542	serum	538:542	serum	538:542	EPO could significantly improve glucose metabolism and activity of total superoxide dismutase in serum.
34894199	2	50	theme	gut	411:413	arg1	microbiota					415:424	gut microbiota	411:424	gut microbiota	411:424	METHODS AND RESULTS LC-MS metabolomics and 16S rRNA sequencing is used to identify the brain metabolites and gut microbiota, respectively.
34894199	1	51	theme	streptozocin-induced	266:285	arg1	mice					296:299	age-matched streptozocin-induced diabetic mice	254:299	age-matched streptozocin-induced diabetic mice	254:299	SCOPE To investigate the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice.
34894199	7	52	from	brain	1037:1041	arg1	Transducer					927:936	the Signal Transducer	916:936	the Signal Transducer	916:936	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	52	from	brain	1037:1041	arg1	JNK					1076:1078	JNK	1076:1078	JNK	1076:1078	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	52	from	brain	1037:1041	arg1	Kinase					1068:1073	the c-Jun N-terminal Kinase	1047:1073	the c-Jun N-terminal Kinase (JNK)	1047:1079	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	52	from	brain	1037:1041	arg1	Activator					942:950	Activator	942:950	Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain	942:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	4	53	theme	aged	663:666	arg1	mice					677:680	aged diabetic mice	663:680	aged diabetic mice	663:680	It also could regulate the tricarboxylic acid cycle, arginine, and inosine-related metabolic pathways in the brain of aged diabetic mice.
34894199	3	54	from	activity	496:503	arg1	serum					538:542	serum	538:542	serum	538:542	EPO could significantly improve glucose metabolism and activity of total superoxide dismutase in serum.
34894199	4	55	theme	metabolic	628:636	arg1	pathways					638:645	inosine-related metabolic pathways	612:645	inosine-related metabolic pathways	612:645	It also could regulate the tricarboxylic acid cycle, arginine, and inosine-related metabolic pathways in the brain of aged diabetic mice.
34894199	7	56	theme	Signal	920:925	arg1	Transducer					927:936	the Signal Transducer	916:936	the Signal Transducer	916:936	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	2	57	theme	LC-MS	322:326	arg1	metabolomics					328:339	METHODS AND RESULTS LC-MS metabolomics	302:339	METHODS AND RESULTS LC-MS metabolomics	302:339	METHODS AND RESULTS LC-MS metabolomics and 16S rRNA sequencing is used to identify the brain metabolites and gut microbiota, respectively.
34894199	8	58	theme	peptide	1234:1240	arg1	type					1242:1245	glucagon-like peptide type 1	1220:1247	glucagon-like peptide type 1 (GLP1) expression	1220:1265	EPO could also improve the levels of glucagon-like peptide type 1 (GLP1) expression in the gut, thereby inducing high expression of GLP1 receptor in the brain to control glucose metabolites through the brain-gut axis.
34894199	8	58	theme	peptide	1234:1240	arg1	GLP1					1250:1253	GLP1	1250:1253	GLP1	1250:1253	EPO could also improve the levels of glucagon-like peptide type 1 (GLP1) expression in the gut, thereby inducing high expression of GLP1 receptor in the brain to control glucose metabolites through the brain-gut axis.
34894199	10	59	theme	potential	1582:1590	arg1	drug					1606:1609	a potential novel natural drug	1580:1609	a potential novel natural drug for the treatment of diabetes in the elderly	1580:1654	CONCLUSIONS These results suggest that EPO could be a potential novel natural drug for the treatment of diabetes in the elderly.
34894199	10	59	theme	potential	1582:1590	arg1	EPO					1567:1569	EPO	1567:1569	EPO	1567:1569	CONCLUSIONS These results suggest that EPO could be a potential novel natural drug for the treatment of diabetes in the elderly.
34894199	7	60	theme	/FOXO1/Bcl-6	1080:1091	arg1	axis					1103:1106	/FOXO1/Bcl-6 signaling axis	1080:1106	/FOXO1/Bcl-6 signaling axis	1080:1106	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	1	61	theme	Enteromorpha	206:217	arg1	EPO					246:248	EPO	246:248	EPO	246:248	SCOPE To investigate the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice.
34894199	1	61	theme	Enteromorpha	206:217	arg1	oligosaccharide					229:243	Enteromorpha prolifera oligosaccharide	206:243	Enteromorpha prolifera oligosaccharide (EPO)	206:249	SCOPE To investigate the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice.
34894199	2	62	theme	rRNA	349:352	arg1	sequencing					354:363	16S rRNA sequencing	345:363	16S rRNA sequencing	345:363	METHODS AND RESULTS LC-MS metabolomics and 16S rRNA sequencing is used to identify the brain metabolites and gut microbiota, respectively.
34894199	1	63	theme	oligosaccharide	229:243	arg1	effects					195:201	the anti-ageing and anti-diabetic effects	161:201	the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice	161:299	SCOPE To investigate the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice.
34894199	0	64	from	Axis	105:108	arg1	Mice					134:137	Age-Matched Diabetic Mice	113:137	Age-Matched Diabetic Mice	113:137	Green Alga Enteromorpha prolifera Oligosaccharide Ameliorates Ageing and Hyperglycemia through Gut-Brain Axis in Age-Matched Diabetic Mice.
34894199	9	65	theme	age-related	1506:1516	arg1	diabetes					1518:1525	age-related diabetes	1506:1525	age-related diabetes	1506:1525	Enterococcus is negatively correlated with AMP in the brain and could be a potential hallmark species in age-related diabetes.
34894199	4	66	theme	mice	677:680	arg1	brain					654:658	the brain	650:658	the brain of aged diabetic mice	650:680	It also could regulate the tricarboxylic acid cycle, arginine, and inosine-related metabolic pathways in the brain of aged diabetic mice.
34894199	8	67	theme	expression	1256:1265	arg1	levels					1210:1215	the levels	1206:1215	the levels of glucagon-like peptide type 1 (GLP1) expression	1206:1265	EPO could also improve the levels of glucagon-like peptide type 1 (GLP1) expression in the gut, thereby inducing high expression of GLP1 receptor in the brain to control glucose metabolites through the brain-gut axis.
34894199	10	68	theme	natural	1598:1604	arg1	drug					1606:1609	a potential novel natural drug	1580:1609	a potential novel natural drug for the treatment of diabetes in the elderly	1580:1654	CONCLUSIONS These results suggest that EPO could be a potential novel natural drug for the treatment of diabetes in the elderly.
34894199	10	68	theme	natural	1598:1604	arg1	EPO					1567:1569	EPO	1567:1569	EPO	1567:1569	CONCLUSIONS These results suggest that EPO could be a potential novel natural drug for the treatment of diabetes in the elderly.
34894199	5	69	theme	skn-1	758:762	arg1	expressions					724:734	the relative expressions	711:734	the relative expressions of daf-2, daf-16, and skn-1 in insulin-resistant Caenorhabditis elegans	711:806	Inosine is found to enhance the relative expressions of daf-2, daf-16, and skn-1 in insulin-resistant Caenorhabditis elegans.
34894199	5	70	theme	relative	715:722	arg1	expressions					724:734	the relative expressions	711:734	the relative expressions of daf-2, daf-16, and skn-1 in insulin-resistant Caenorhabditis elegans	711:806	Inosine is found to enhance the relative expressions of daf-2, daf-16, and skn-1 in insulin-resistant Caenorhabditis elegans.
34894199	9	71	theme	hallmark	1486:1493	arg1	species					1495:1501	a potential hallmark species	1474:1501	a potential hallmark species in age-related diabetes	1474:1525	Enterococcus is negatively correlated with AMP in the brain and could be a potential hallmark species in age-related diabetes.
34894199	7	72	from	status	1156:1161	arg1	mice					1177:1180	mice	1177:1180	mice	1177:1180	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	0	73	theme	Age-Matched	113:123	arg1	Mice					134:137	Age-Matched Diabetic Mice	113:137	Age-Matched Diabetic Mice	113:137	Green Alga Enteromorpha prolifera Oligosaccharide Ameliorates Ageing and Hyperglycemia through Gut-Brain Axis in Age-Matched Diabetic Mice.
34894199	7	74	theme	lymphoma	1002:1009	arg1	pathways					1021:1028	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways	955:1028	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain	955:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	75	from	ageing	1167:1172	arg1	mice					1177:1180	mice	1177:1180	mice	1177:1180	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	8	76	theme	GLP1	1315:1318	arg1	receptor					1320:1327	GLP1 receptor	1315:1327	GLP1 receptor	1315:1327	EPO could also improve the levels of glucagon-like peptide type 1 (GLP1) expression in the gut, thereby inducing high expression of GLP1 receptor in the brain to control glucose metabolites through the brain-gut axis.
34894199	5	77	theme	insulin-resistant	767:783	arg1	elegans					800:806	insulin-resistant Caenorhabditis elegans	767:806	insulin-resistant Caenorhabditis elegans	767:806	Inosine is found to enhance the relative expressions of daf-2, daf-16, and skn-1 in insulin-resistant Caenorhabditis elegans.
34894199	7	78	theme	/B	994:995	arg1	Bcl-6					1014:1018	Bcl-6	1014:1018	Bcl-6	1014:1018	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	78	theme	/B	994:995	arg1	lymphoma					1002:1009	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6	955:1011	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain	955:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	2	79	used	used	368:371	arg2	sequencing					354:363	16S rRNA sequencing	345:363	16S rRNA sequencing	345:363	METHODS AND RESULTS LC-MS metabolomics and 16S rRNA sequencing is used to identify the brain metabolites and gut microbiota, respectively.
34894199	2	79	used	used	368:371	arg2	metabolomics					328:339	METHODS AND RESULTS LC-MS metabolomics	302:339	METHODS AND RESULTS LC-MS metabolomics	302:339	METHODS AND RESULTS LC-MS metabolomics and 16S rRNA sequencing is used to identify the brain metabolites and gut microbiota, respectively.
34894199	0	80	theme	Alga	6:9	arg1	Oligosaccharide					34:48	Green Alga Enteromorpha prolifera Oligosaccharide	0:48	Green Alga Enteromorpha prolifera Oligosaccharide	0:48	Green Alga Enteromorpha prolifera Oligosaccharide Ameliorates Ageing and Hyperglycemia through Gut-Brain Axis in Age-Matched Diabetic Mice.
34894199	7	81	theme	FOXO1	988:992	arg1	Bcl-6					1014:1018	Bcl-6	1014:1018	Bcl-6	1014:1018	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	81	theme	FOXO1	988:992	arg1	lymphoma					1002:1009	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6	955:1011	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain	955:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	0	82	theme	prolifera	24:32	arg1	Oligosaccharide					34:48	Green Alga Enteromorpha prolifera Oligosaccharide	0:48	Green Alga Enteromorpha prolifera Oligosaccharide	0:48	Green Alga Enteromorpha prolifera Oligosaccharide Ameliorates Ageing and Hyperglycemia through Gut-Brain Axis in Age-Matched Diabetic Mice.
34894199	7	83	theme	O1	984:985	arg1	Bcl-6					1014:1018	Bcl-6	1014:1018	Bcl-6	1014:1018	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	83	theme	O1	984:985	arg1	lymphoma					1002:1009	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6	955:1011	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain	955:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	4	84	theme	inosine-related	612:626	arg1	pathways					638:645	inosine-related metabolic pathways	612:645	inosine-related metabolic pathways	612:645	It also could regulate the tricarboxylic acid cycle, arginine, and inosine-related metabolic pathways in the brain of aged diabetic mice.
34894199	3	85	theme	dismutase	525:533	arg1	activity					496:503	activity	496:503	activity	496:503	EPO could significantly improve glucose metabolism and activity of total superoxide dismutase in serum.
34894199	3	85	theme	dismutase	525:533	arg1	metabolism					481:490	glucose metabolism	473:490	glucose metabolism	473:490	EPO could significantly improve glucose metabolism and activity of total superoxide dismutase in serum.
34894199	4	86	theme	acid	586:589	arg1	cycle					591:595	the tricarboxylic acid cycle	568:595	the tricarboxylic acid cycle	568:595	It also could regulate the tricarboxylic acid cycle, arginine, and inosine-related metabolic pathways in the brain of aged diabetic mice.
34894199	0	87	theme	Diabetic	125:132	arg1	Mice					134:137	Age-Matched Diabetic Mice	113:137	Age-Matched Diabetic Mice	113:137	Green Alga Enteromorpha prolifera Oligosaccharide Ameliorates Ageing and Hyperglycemia through Gut-Brain Axis in Age-Matched Diabetic Mice.
34894199	7	88	theme	glucose	1137:1143	arg1	status					1156:1161	glucose metabolite status	1137:1161	glucose metabolite status	1137:1161	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	89	theme	Transcription	955:967	arg1	Bcl-6					1014:1018	Bcl-6	1014:1018	Bcl-6	1014:1018	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	7	89	theme	Transcription	955:967	arg1	lymphoma					1002:1009	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6	955:1011	Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain	955:1041	It could upregulate the Signal Transducer and Activator of Transcription 3/Forkhead Box O1 (FOXO1)/B cell lymphoma 6 (Bcl-6) pathways in the brain and the c-Jun N-terminal Kinase (JNK)/FOXO1/Bcl-6 signaling axis in the intestine to regulate glucose metabolite status and ageing in mice.
34894199	1	90	theme	age-matched	254:264	arg1	mice					296:299	age-matched streptozocin-induced diabetic mice	254:299	age-matched streptozocin-induced diabetic mice	254:299	SCOPE To investigate the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice.
34894199	6	91	theme	gut	872:874	arg1	microbiota					876:885	gut microbiota	872:885	gut microbiota	872:885	Additionally, EPO could alter the composition and diversity of gut microbiota in mice.
34894199	9	92	from	AMP	1444:1446	arg1	brain					1455:1459	the brain	1451:1459	the brain	1451:1459	Enterococcus is negatively correlated with AMP in the brain and could be a potential hallmark species in age-related diabetes.
34894199	4	93	theme	diabetic	668:675	arg1	mice					677:680	aged diabetic mice	663:680	aged diabetic mice	663:680	It also could regulate the tricarboxylic acid cycle, arginine, and inosine-related metabolic pathways in the brain of aged diabetic mice.
34894199	1	94	theme	diabetic	287:294	arg1	mice					296:299	age-matched streptozocin-induced diabetic mice	254:299	age-matched streptozocin-induced diabetic mice	254:299	SCOPE To investigate the anti-ageing and anti-diabetic effects of Enteromorpha prolifera oligosaccharide (EPO) in age-matched streptozocin-induced diabetic mice.
34894199	5	95	from	expressions	724:734	arg1	elegans					800:806	insulin-resistant Caenorhabditis elegans	767:806	insulin-resistant Caenorhabditis elegans	767:806	Inosine is found to enhance the relative expressions of daf-2, daf-16, and skn-1 in insulin-resistant Caenorhabditis elegans.
34096072	8	0	theme	characterization	1328:1343	arg1	results					1345:1351	isolation and characterization results	1314:1351	isolation and characterization results	1314:1351	CONCLUSION Overall, isolation and characterization results indicated the potential for CNCs preparation using sugarcane straw, in addition to offering a fundamental understanding of this material and indicating potential applications.
34096072	1	1	theme	lignocellulosic	169:183	arg1	straw					127:131	BACKGROUND Sugarcane straw	106:131	BACKGROUND Sugarcane straw	106:131	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	1	1	theme	lignocellulosic	169:183	arg1	biomass					185:191	an available but largely ignored lignocellulosic biomass	136:191	an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability	136:316	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	1	2	theme	surface	266:272	arg1	chemistries					274:284	highly crystalline, tunable surface chemistries	238:284	highly crystalline, tunable surface chemistries	238:284	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	0	3	theme	sugarcane	89:97	arg1	straw					99:103	agricultural waste sugarcane straw	70:103	agricultural waste sugarcane straw	70:103	Facile extraction and characterization of cellulose nanocrystals from agricultural waste sugarcane straw.
34096072	4	4	contain	contained	711:719	arg1	ATFs					705:708	ATFs	705:708	ATFs	705:708	RESULTS After the purification process, alkali-treated fibers (ATFs) contained 886.33 ± 1.25 g kg-1 cellulose, and its morphological analysis revealed a smooth and slender fibrous structure.
34096072	4	4	contain	contained	711:719	arg1	fibers					697:702	alkali-treated fibers	682:702	alkali-treated fibers (ATFs)	682:709	RESULTS After the purification process, alkali-treated fibers (ATFs) contained 886.33 ± 1.25 g kg-1 cellulose, and its morphological analysis revealed a smooth and slender fibrous structure.
34096072	4	4	contain	contained	711:719	arg2	cellulose					742:750	886.33 ± 1.25 g kg-1 cellulose	721:750	886.33 ± 1.25 g kg-1 cellulose	721:750	RESULTS After the purification process, alkali-treated fibers (ATFs) contained 886.33 ± 1.25 g kg-1 cellulose, and its morphological analysis revealed a smooth and slender fibrous structure.
34096072	5	5	dep	diameter	952:959	arg1	a					950:950	a	950:950	a	950:950	The CNCs obtained by treatment with 64 wt% sulfuric acid at 45 °C for 60 min were isolated in a yield of 21.8%, with a diameter and length of 6 to 10 nm and 160 to 200 nm, respectively.
34096072	9	6	theme	Chemical	1547:1554	arg1	Industry					1556:1563	Chemical Industry	1547:1563	Chemical Industry	1547:1563	© 2021 Society of Chemical Industry.
34096072	4	7	theme	fibrous	814:820	arg1	structure					822:830	a smooth and slender fibrous structure	793:830	structure	822:830	RESULTS After the purification process, alkali-treated fibers (ATFs) contained 886.33 ± 1.25 g kg-1 cellulose, and its morphological analysis revealed a smooth and slender fibrous structure.
34096072	4	8	theme	slender	806:812	arg1	structure					822:830	a smooth and slender fibrous structure	793:830	structure	822:830	RESULTS After the purification process, alkali-treated fibers (ATFs) contained 886.33 ± 1.25 g kg-1 cellulose, and its morphological analysis revealed a smooth and slender fibrous structure.
34096072	7	9	with	charge	1258:1263	arg1	-38.00 mV					1283:1291	higher value -38.00 mV	1270:1291	higher value -38.00 mV	1270:1291	Short-term ultrasonication after hydrolysis was employed to enhance isolation of the CNC particles and improve the anionic charge with higher value -38.00 mV.
34096072	3	10	theme	CNCs	532:535	arg1	properties					485:494	The properties	481:494	The properties of the purified fibers and obtained CNCs	481:535	The properties of the purified fibers and obtained CNCs were assessed by their composition, morphology, chemical structure, crystallinity and thermal stability.
34096072	2	11	dep	utilized	330:337	arg1	followed					408:415	followed	408:415	followed by subsequent preparation of CNCs via sulfuric acid hydrolysis	408:478	Herein, we utilized sugarcane straw to obtain pure cellulose via purification processes, followed by subsequent preparation of CNCs via sulfuric acid hydrolysis.
34096072	6	12	theme	two-step	1113:1120	arg1	degradation					1122:1132	a two-step degradation	1111:1132	a two-step degradation	1111:1132	Moreover, crystallinity index of these CNCs reached 62.66%, and thermal stability underwent a two-step degradation.
34096072	4	13	theme	purification	660:671	arg1	process					673:679	the purification process	656:679	the purification process	656:679	RESULTS After the purification process, alkali-treated fibers (ATFs) contained 886.33 ± 1.25 g kg-1 cellulose, and its morphological analysis revealed a smooth and slender fibrous structure.
34096072	8	14	theme	material	1481:1488	arg1	understanding					1459:1471	a fundamental understanding	1445:1471	a fundamental understanding of this material	1445:1488	CONCLUSION Overall, isolation and characterization results indicated the potential for CNCs preparation using sugarcane straw, in addition to offering a fundamental understanding of this material and indicating potential applications.
34096072	6	15	theme	CNCs	1058:1061	arg1	index					1043:1047	crystallinity index	1029:1047	crystallinity index of these CNCs	1029:1061	Moreover, crystallinity index of these CNCs reached 62.66%, and thermal stability underwent a two-step degradation.
34096072	2	16	theme	subsequent	420:429	arg1	preparation					431:441	subsequent preparation	420:441	subsequent preparation of CNCs via sulfuric acid hydrolysis	420:478	Herein, we utilized sugarcane straw to obtain pure cellulose via purification processes, followed by subsequent preparation of CNCs via sulfuric acid hydrolysis.
34096072	8	17	theme	potential	1505:1513	arg1	applications					1515:1526	potential applications	1505:1526	potential applications	1505:1526	CONCLUSION Overall, isolation and characterization results indicated the potential for CNCs preparation using sugarcane straw, in addition to offering a fundamental understanding of this material and indicating potential applications.
34096072	7	18	theme	Short-term	1135:1144	arg1	ultrasonication					1146:1160	Short-term ultrasonication	1135:1160	Short-term ultrasonication after hydrolysis	1135:1177	Short-term ultrasonication after hydrolysis was employed to enhance isolation of the CNC particles and improve the anionic charge with higher value -38.00 mV.
34096072	8	19	dep	offering	1436:1443	arg1	addition					1424:1431	addition	1424:1431	addition	1424:1431	CONCLUSION Overall, isolation and characterization results indicated the potential for CNCs preparation using sugarcane straw, in addition to offering a fundamental understanding of this material and indicating potential applications.
34096072	5	20	theme	10 nm	980:984	arg1	length					965:970	length	965:970	length	965:970	The CNCs obtained by treatment with 64 wt% sulfuric acid at 45 °C for 60 min were isolated in a yield of 21.8%, with a diameter and length of 6 to 10 nm and 160 to 200 nm, respectively.
34096072	5	20	theme	10 nm	980:984	arg1	diameter					952:959	diameter	952:959	diameter	952:959	The CNCs obtained by treatment with 64 wt% sulfuric acid at 45 °C for 60 min were isolated in a yield of 21.8%, with a diameter and length of 6 to 10 nm and 160 to 200 nm, respectively.
34096072	7	21	theme	CNC	1220:1222	arg1	particles					1224:1232	the CNC particles	1216:1232	the CNC particles	1216:1232	Short-term ultrasonication after hydrolysis was employed to enhance isolation of the CNC particles and improve the anionic charge with higher value -38.00 mV.
34096072	7	22	theme	particles	1224:1232	arg1	isolation					1203:1211	isolation	1203:1211	isolation of the CNC particles	1203:1232	Short-term ultrasonication after hydrolysis was employed to enhance isolation of the CNC particles and improve the anionic charge with higher value -38.00 mV.
34096072	2	23	theme	sugarcane	339:347	arg1	straw					349:353	sugarcane straw	339:353	sugarcane straw	339:353	Herein, we utilized sugarcane straw to obtain pure cellulose via purification processes, followed by subsequent preparation of CNCs via sulfuric acid hydrolysis.
34096072	7	24	theme	higher	1270:1275	arg1	-38.00 mV					1283:1291	higher value -38.00 mV	1270:1291	higher value -38.00 mV	1270:1291	Short-term ultrasonication after hydrolysis was employed to enhance isolation of the CNC particles and improve the anionic charge with higher value -38.00 mV.
34096072	1	25	theme	cellulose	203:211	arg1	CNCs					227:230	CNCs	227:230	CNCs	227:230	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	1	25	theme	cellulose	203:211	arg1	nanocrystals					213:224	cellulose nanocrystals	203:224	cellulose nanocrystals (CNCs)	203:231	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	0	26	theme	Facile	0:5	arg1	extraction					7:16	Facile extraction	0:16	Facile extraction	0:16	Facile extraction and characterization of cellulose nanocrystals from agricultural waste sugarcane straw.
34096072	1	27	theme	wide-ranging	292:303	arg1	adaptability					305:316	a wide-ranging adaptability	290:316	a wide-ranging adaptability	290:316	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	4	28	theme	morphological	761:773	arg1	analysis					775:782	its morphological analysis	757:782	its morphological analysis	757:782	RESULTS After the purification process, alkali-treated fibers (ATFs) contained 886.33 ± 1.25 g kg-1 cellulose, and its morphological analysis revealed a smooth and slender fibrous structure.
34096072	1	29	theme	BACKGROUND	106:115	arg1	biomass					185:191	an available but largely ignored lignocellulosic biomass	136:191	an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability	136:316	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	1	29	theme	BACKGROUND	106:115	arg1	straw					127:131	BACKGROUND Sugarcane straw	106:131	BACKGROUND Sugarcane straw	106:131	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	5	30	dep	200 nm	997:1002	arg1	to					994:995	to	994:995	to	994:995	The CNCs obtained by treatment with 64 wt% sulfuric acid at 45 °C for 60 min were isolated in a yield of 21.8%, with a diameter and length of 6 to 10 nm and 160 to 200 nm, respectively.
34096072	2	31	theme	acid	464:467	arg1	hydrolysis					469:478	sulfuric acid hydrolysis	455:478	sulfuric acid hydrolysis	455:478	Herein, we utilized sugarcane straw to obtain pure cellulose via purification processes, followed by subsequent preparation of CNCs via sulfuric acid hydrolysis.
34096072	7	32	theme	anionic	1250:1256	arg1	charge					1258:1263	the anionic charge	1246:1263	the anionic charge with higher value -38.00 mV	1246:1291	Short-term ultrasonication after hydrolysis was employed to enhance isolation of the CNC particles and improve the anionic charge with higher value -38.00 mV.
34096072	1	33	theme	Sugarcane	117:125	arg1	biomass					185:191	an available but largely ignored lignocellulosic biomass	136:191	an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability	136:316	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	1	33	theme	Sugarcane	117:125	arg1	straw					127:131	BACKGROUND Sugarcane straw	106:131	BACKGROUND Sugarcane straw	106:131	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	5	34	theme	sulfuric	876:883	arg1	acid					885:888	64 wt% sulfuric acid	869:888	64 wt% sulfuric acid at 45 °C for 60 min	869:908	The CNCs obtained by treatment with 64 wt% sulfuric acid at 45 °C for 60 min were isolated in a yield of 21.8%, with a diameter and length of 6 to 10 nm and 160 to 200 nm, respectively.
34096072	2	35	theme	sulfuric	455:462	arg1	hydrolysis					469:478	sulfuric acid hydrolysis	455:478	sulfuric acid hydrolysis	455:478	Herein, we utilized sugarcane straw to obtain pure cellulose via purification processes, followed by subsequent preparation of CNCs via sulfuric acid hydrolysis.
34096072	0	36	from	straw	99:103	arg1	characterization					22:37	characterization	22:37	characterization	22:37	Facile extraction and characterization of cellulose nanocrystals from agricultural waste sugarcane straw.
34096072	0	36	from	straw	99:103	arg1	extraction					7:16	Facile extraction	0:16	Facile extraction	0:16	Facile extraction and characterization of cellulose nanocrystals from agricultural waste sugarcane straw.
34096072	3	37	theme	chemical	585:592	arg1	structure					594:602	chemical structure	585:602	chemical structure	585:602	The properties of the purified fibers and obtained CNCs were assessed by their composition, morphology, chemical structure, crystallinity and thermal stability.
34096072	2	38	theme	CNCs	446:449	arg1	preparation					431:441	subsequent preparation	420:441	subsequent preparation of CNCs via sulfuric acid hydrolysis	420:478	Herein, we utilized sugarcane straw to obtain pure cellulose via purification processes, followed by subsequent preparation of CNCs via sulfuric acid hydrolysis.
34096072	0	39	theme	cellulose	42:50	arg1	nanocrystals					52:63	cellulose nanocrystals	42:63	cellulose nanocrystals	42:63	Facile extraction and characterization of cellulose nanocrystals from agricultural waste sugarcane straw.
34096072	5	40	theme	%	942:942	arg1	yield					929:933	a yield	927:933	a yield of 21.8%	927:942	The CNCs obtained by treatment with 64 wt% sulfuric acid at 45 °C for 60 min were isolated in a yield of 21.8%, with a diameter and length of 6 to 10 nm and 160 to 200 nm, respectively.
34096072	6	41	theme	crystallinity	1029:1041	arg1	index					1043:1047	crystallinity index	1029:1047	crystallinity index of these CNCs	1029:1061	Moreover, crystallinity index of these CNCs reached 62.66%, and thermal stability underwent a two-step degradation.
34096072	3	42	theme	thermal	623:629	arg1	stability					631:639	thermal stability	623:639	thermal stability	623:639	The properties of the purified fibers and obtained CNCs were assessed by their composition, morphology, chemical structure, crystallinity and thermal stability.
34096072	4	43	theme	alkali-treated	682:695	arg1	ATFs					705:708	ATFs	705:708	ATFs	705:708	RESULTS After the purification process, alkali-treated fibers (ATFs) contained 886.33 ± 1.25 g kg-1 cellulose, and its morphological analysis revealed a smooth and slender fibrous structure.
34096072	4	43	theme	alkali-treated	682:695	arg1	fibers					697:702	alkali-treated fibers	682:702	alkali-treated fibers (ATFs)	682:709	RESULTS After the purification process, alkali-treated fibers (ATFs) contained 886.33 ± 1.25 g kg-1 cellulose, and its morphological analysis revealed a smooth and slender fibrous structure.
34096072	8	44	theme	isolation	1314:1322	arg1	results					1345:1351	isolation and characterization results	1314:1351	isolation and characterization results	1314:1351	CONCLUSION Overall, isolation and characterization results indicated the potential for CNCs preparation using sugarcane straw, in addition to offering a fundamental understanding of this material and indicating potential applications.
34096072	5	45	theme	64 wt	869:873	arg1	acid					885:888	64 wt% sulfuric acid	869:888	64 wt% sulfuric acid at 45 °C for 60 min	869:908	The CNCs obtained by treatment with 64 wt% sulfuric acid at 45 °C for 60 min were isolated in a yield of 21.8%, with a diameter and length of 6 to 10 nm and 160 to 200 nm, respectively.
34096072	8	46	dep	indicated	1353:1361	arg1	Overall					1305:1311	Overall	1305:1311	Overall	1305:1311	CONCLUSION Overall, isolation and characterization results indicated the potential for CNCs preparation using sugarcane straw, in addition to offering a fundamental understanding of this material and indicating potential applications.
34096072	6	47	theme	thermal	1083:1089	arg1	stability					1091:1099	thermal stability	1083:1099	thermal stability	1083:1099	Moreover, crystallinity index of these CNCs reached 62.66%, and thermal stability underwent a two-step degradation.
34096072	1	48	dep	crystalline	245:255	arg1	tunable					258:264	tunable	258:264	tunable	258:264	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	5	49	from	45 °C	893:897	arg1	acid					885:888	64 wt% sulfuric acid	869:888	64 wt% sulfuric acid at 45 °C for 60 min	869:908	The CNCs obtained by treatment with 64 wt% sulfuric acid at 45 °C for 60 min were isolated in a yield of 21.8%, with a diameter and length of 6 to 10 nm and 160 to 200 nm, respectively.
34096072	2	50	theme	pure	365:368	arg1	cellulose					370:378	pure cellulose	365:378	pure cellulose	365:378	Herein, we utilized sugarcane straw to obtain pure cellulose via purification processes, followed by subsequent preparation of CNCs via sulfuric acid hydrolysis.
34096072	0	51	theme	nanocrystals	52:63	arg1	characterization					22:37	characterization	22:37	characterization	22:37	Facile extraction and characterization of cellulose nanocrystals from agricultural waste sugarcane straw.
34096072	0	51	theme	nanocrystals	52:63	arg1	extraction					7:16	Facile extraction	0:16	Facile extraction	0:16	Facile extraction and characterization of cellulose nanocrystals from agricultural waste sugarcane straw.
34096072	3	52	theme	purified	503:510	arg1	fibers					512:517	the purified fibers	499:517	the purified fibers	499:517	The properties of the purified fibers and obtained CNCs were assessed by their composition, morphology, chemical structure, crystallinity and thermal stability.
34096072	7	53	theme	value	1277:1281	arg1	-38.00 mV					1283:1291	higher value -38.00 mV	1270:1291	higher value -38.00 mV	1270:1291	Short-term ultrasonication after hydrolysis was employed to enhance isolation of the CNC particles and improve the anionic charge with higher value -38.00 mV.
34096072	3	54	theme	obtained	523:530	arg1	CNCs					532:535	obtained CNCs	523:535	obtained CNCs	523:535	The properties of the purified fibers and obtained CNCs were assessed by their composition, morphology, chemical structure, crystallinity and thermal stability.
34096072	5	55	theme	200 nm	997:1002	arg1	length					965:970	length	965:970	length	965:970	The CNCs obtained by treatment with 64 wt% sulfuric acid at 45 °C for 60 min were isolated in a yield of 21.8%, with a diameter and length of 6 to 10 nm and 160 to 200 nm, respectively.
34096072	5	55	theme	200 nm	997:1002	arg1	diameter					952:959	diameter	952:959	diameter	952:959	The CNCs obtained by treatment with 64 wt% sulfuric acid at 45 °C for 60 min were isolated in a yield of 21.8%, with a diameter and length of 6 to 10 nm and 160 to 200 nm, respectively.
34096072	8	56	theme	CNCs	1381:1384	arg1	preparation					1386:1396	CNCs preparation	1381:1396	CNCs preparation using sugarcane straw	1381:1418	CONCLUSION Overall, isolation and characterization results indicated the potential for CNCs preparation using sugarcane straw, in addition to offering a fundamental understanding of this material and indicating potential applications.
34096072	1	57	theme	available	139:147	arg1	straw					127:131	BACKGROUND Sugarcane straw	106:131	BACKGROUND Sugarcane straw	106:131	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	1	57	theme	available	139:147	arg1	biomass					185:191	an available but largely ignored lignocellulosic biomass	136:191	an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability	136:316	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	5	58	with	treatment	854:862	arg1	acid					885:888	64 wt% sulfuric acid	869:888	64 wt% sulfuric acid at 45 °C for 60 min	869:908	The CNCs obtained by treatment with 64 wt% sulfuric acid at 45 °C for 60 min were isolated in a yield of 21.8%, with a diameter and length of 6 to 10 nm and 160 to 200 nm, respectively.
34096072	4	59	dep	RESULTS	642:648	arg1	process					673:679	the purification process	656:679	the purification process	656:679	RESULTS After the purification process, alkali-treated fibers (ATFs) contained 886.33 ± 1.25 g kg-1 cellulose, and its morphological analysis revealed a smooth and slender fibrous structure.
34096072	1	60	theme	ignored	161:167	arg1	straw					127:131	BACKGROUND Sugarcane straw	106:131	BACKGROUND Sugarcane straw	106:131	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	1	60	theme	ignored	161:167	arg1	biomass					185:191	an available but largely ignored lignocellulosic biomass	136:191	an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability	136:316	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	2	61	used	utilized	330:337	arg2	we					327:328	we	327:328	we	327:328	Herein, we utilized sugarcane straw to obtain pure cellulose via purification processes, followed by subsequent preparation of CNCs via sulfuric acid hydrolysis.
34096072	1	62	theme	crystalline	245:255	arg1	chemistries					274:284	highly crystalline, tunable surface chemistries	238:284	highly crystalline, tunable surface chemistries	238:284	BACKGROUND Sugarcane straw is an available but largely ignored lignocellulosic biomass to obtain cellulose nanocrystals (CNCs) with highly crystalline, tunable surface chemistries and a wide-ranging adaptability.
34096072	0	63	theme	waste	83:87	arg1	straw					99:103	agricultural waste sugarcane straw	70:103	agricultural waste sugarcane straw	70:103	Facile extraction and characterization of cellulose nanocrystals from agricultural waste sugarcane straw.
34096072	8	64	theme	sugarcane	1404:1412	arg1	straw					1414:1418	sugarcane straw	1404:1418	sugarcane straw	1404:1418	CONCLUSION Overall, isolation and characterization results indicated the potential for CNCs preparation using sugarcane straw, in addition to offering a fundamental understanding of this material and indicating potential applications.
34096072	8	65	theme	fundamental	1447:1457	arg1	understanding					1459:1471	a fundamental understanding	1445:1471	a fundamental understanding of this material	1445:1488	CONCLUSION Overall, isolation and characterization results indicated the potential for CNCs preparation using sugarcane straw, in addition to offering a fundamental understanding of this material and indicating potential applications.
34096072	5	66	dep	10 nm	980:984	arg1	to					977:978	to	977:978	to	977:978	The CNCs obtained by treatment with 64 wt% sulfuric acid at 45 °C for 60 min were isolated in a yield of 21.8%, with a diameter and length of 6 to 10 nm and 160 to 200 nm, respectively.
34096072	4	67	theme	886.33 ± 1.25 g kg-1	721:740	arg1	cellulose					742:750	886.33 ± 1.25 g kg-1 cellulose	721:750	886.33 ± 1.25 g kg-1 cellulose	721:750	RESULTS After the purification process, alkali-treated fibers (ATFs) contained 886.33 ± 1.25 g kg-1 cellulose, and its morphological analysis revealed a smooth and slender fibrous structure.
34096072	3	68	theme	fibers	512:517	arg1	properties					485:494	The properties	481:494	The properties of the purified fibers and obtained CNCs	481:535	The properties of the purified fibers and obtained CNCs were assessed by their composition, morphology, chemical structure, crystallinity and thermal stability.
34096072	0	69	theme	agricultural	70:81	arg1	straw					99:103	agricultural waste sugarcane straw	70:103	agricultural waste sugarcane straw	70:103	Facile extraction and characterization of cellulose nanocrystals from agricultural waste sugarcane straw.
34096072	5	70	theme	%	874:874	arg1	acid					885:888	64 wt% sulfuric acid	869:888	64 wt% sulfuric acid at 45 °C for 60 min	869:908	The CNCs obtained by treatment with 64 wt% sulfuric acid at 45 °C for 60 min were isolated in a yield of 21.8%, with a diameter and length of 6 to 10 nm and 160 to 200 nm, respectively.
34096072	2	71	theme	purification	384:395	arg1	processes					397:405	purification processes	384:405	purification processes	384:405	Herein, we utilized sugarcane straw to obtain pure cellulose via purification processes, followed by subsequent preparation of CNCs via sulfuric acid hydrolysis.
31988034	1	0	theme	active	171:176	arg1	APIs					206:209	APIs	206:209	APIs	206:209	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	1	0	theme	active	171:176	arg1	ingredients					193:203	active pharmaceutical ingredients	171:203	poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs)	150:260	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	6	1	theme	hydroxyppropyl	969:982	arg1	polymers					875:882	the pharmaceutically relevant polymers	845:882	the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water	845:1130	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	1	theme	hydroxyppropyl	969:982	arg1	HPMCAS					1024:1029	HPMCAS	1024:1029	HPMCAS	1024:1029	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	1	theme	hydroxyppropyl	969:982	arg1	126G					1018:1021	hydroxyppropyl methylcellulose acetate succinate 126G	969:1021	hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS)	969:1030	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	5	2	theme	polymer-solvent	724:738	arg1	interactions					740:751	the polymer-solvent interactions	720:751	the polymer-solvent interactions in these mixtures	720:769	Therefore, this work investigates the polymer-solvent interactions in these mixtures.
31988034	5	3	from	interactions	740:751	arg1	mixtures					762:769	these mixtures	756:769	these mixtures	756:769	Therefore, this work investigates the polymer-solvent interactions in these mixtures.
31988034	12	4	theme	suitable	1850:1857	arg1	solvents					1859:1866	suitable solvents	1850:1866	suitable solvents	1850:1866	Thus, the proposed methodology allows identifying suitable solvents or solvent mixtures relevant for solvent-based preparations of pharmaceutical ASD formulations with low experimental effort.
31988034	1	5	theme	pharmaceutical	178:191	arg1	APIs					206:209	APIs	206:209	APIs	206:209	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	1	5	theme	pharmaceutical	178:191	arg1	ingredients					193:203	active pharmaceutical ingredients	171:203	poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs)	150:260	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	11	6	theme	molecular	1693:1701	arg1	weight					1703:1708	polymer molecular weight	1685:1708	polymer molecular weight	1685:1708	In addition, the impact of temperature, polymer molecular weight, and solvent-mixture composition on miscibility was successfully predicted using PC-SAFT.
31988034	12	7	theme	solvent	1871:1877	arg1	mixtures					1879:1886	solvent mixtures	1871:1886	solvent mixtures	1871:1886	Thus, the proposed methodology allows identifying suitable solvents or solvent mixtures relevant for solvent-based preparations of pharmaceutical ASD formulations with low experimental effort.
31988034	6	8	theme	polymer/solvent	781:795	arg1	combinations					797:808	Suitable polymer/solvent combinations	772:808	Suitable polymer/solvent combinations investigated in this work	772:834	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	2	9	dep	dissolved	344:352	arg1	both					339:342	both	339:342	both	339:342	ASDs can be produced via solvent-based processes, where API and polymer are both dissolved in a solvent, followed by a solvent evaporation step (e.g. spray drying).
31988034	11	10	theme	temperature	1672:1682	arg1	impact					1662:1667	the impact	1658:1667	the impact of temperature, polymer molecular weight, and solvent-mixture composition on miscibility	1658:1756	In addition, the impact of temperature, polymer molecular weight, and solvent-mixture composition on miscibility was successfully predicted using PC-SAFT.
31988034	7	11	theme	vapor-sorption	1142:1155	arg1	experiments					1157:1167	vapor-sorption experiments	1142:1167	vapor-sorption experiments demixing of solvents and polymers	1142:1201	Based on vapor-sorption experiments demixing of solvents and polymers were predicted using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT).
31988034	6	12	theme	Suitable	772:779	arg1	combinations					797:808	Suitable polymer/solvent combinations	772:808	Suitable polymer/solvent combinations investigated in this work	772:834	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	4	13	theme	mixtures	652:659	arg1	behavior					624:631	the phase behavior	614:631	the phase behavior of polymer/solvent mixtures used for ASD processing	614:683	The latter is often determined by the phase behavior of polymer/solvent mixtures used for ASD processing.
31988034	4	14	theme	ASD	670:672	arg1	processing					674:683	ASD processing	670:683	ASD processing	670:683	The latter is often determined by the phase behavior of polymer/solvent mixtures used for ASD processing.
31988034	4	15	theme	polymer/solvent	636:650	arg1	mixtures					652:659	polymer/solvent mixtures	636:659	polymer/solvent mixtures used for ASD processing	636:683	The latter is often determined by the phase behavior of polymer/solvent mixtures used for ASD processing.
31988034	1	16	used	used	115:118	arg2	polymers					102:109	polymers	102:109	polymers	102:109	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	1	16	used	used	115:118	arg2	excipients					123:132	excipients	123:132	excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs)	123:260	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	9	17	with	miscible	1441:1448	arg1	PVPVA64					1455:1461	PVPVA64	1455:1461	PVPVA64	1455:1461	Acetone, DCM, ethanol, methanol, and water were found to be completely miscible with PVPVA64.
31988034	2	18	theme	evaporation	390:400	arg1	step					402:405	a solvent evaporation step	380:405	a solvent evaporation step (e.g. spray drying)	380:425	ASDs can be produced via solvent-based processes, where API and polymer are both dissolved in a solvent, followed by a solvent evaporation step (e.g. spray drying).
31988034	1	19	theme	pharmaceutical	77:90	arg1	industry					92:99	the pharmaceutical industry	73:99	the pharmaceutical industry	73:99	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	12	20	theme	low	1968:1970	arg1	effort					1985:1990	low experimental effort	1968:1990	low experimental effort	1968:1990	Thus, the proposed methodology allows identifying suitable solvents or solvent mixtures relevant for solvent-based preparations of pharmaceutical ASD formulations with low experimental effort.
31988034	10	21	theme	solvents	1580:1587	arg1	none					1555:1558	none	1555:1558	none of the investigated solvents	1555:1587	DCM, ethanol, methanol, and water were found to be completely miscible with PVP K90, while none of the investigated solvents was appropriate for avoiding immiscibility with HPMCAS.
31988034	11	22	theme	polymer	1685:1691	arg1	weight					1703:1708	polymer molecular weight	1685:1708	polymer molecular weight	1685:1708	In addition, the impact of temperature, polymer molecular weight, and solvent-mixture composition on miscibility was successfully predicted using PC-SAFT.
31988034	0	23	theme	Phase	0:4	arg1	behavior					6:13	Phase behavior	0:13	Phase behavior of pharmaceutically relevant polymer/solvent	0:58	Phase behavior of pharmaceutically relevant polymer/solvent mixtures.
31988034	12	24	theme	experimental	1972:1983	arg1	effort					1985:1990	low experimental effort	1968:1990	low experimental effort	1968:1990	Thus, the proposed methodology allows identifying suitable solvents or solvent mixtures relevant for solvent-based preparations of pharmaceutical ASD formulations with low experimental effort.
31988034	2	25	dep	drying	419:424	arg1	e.g.					408:411	e.g.	408:411	e.g.	408:411	ASDs can be produced via solvent-based processes, where API and polymer are both dissolved in a solvent, followed by a solvent evaporation step (e.g. spray drying).
31988034	4	26	theme	phase	618:622	arg1	behavior					624:631	the phase behavior	614:631	the phase behavior of polymer/solvent mixtures used for ASD processing	614:683	The latter is often determined by the phase behavior of polymer/solvent mixtures used for ASD processing.
31988034	2	27	theme	spray	413:417	arg1	drying					419:424	spray drying	413:424	spray drying	413:424	ASDs can be produced via solvent-based processes, where API and polymer are both dissolved in a solvent, followed by a solvent evaporation step (e.g. spray drying).
31988034	12	28	theme	relevant	1888:1895	arg1	solvents					1859:1866	suitable solvents	1850:1866	suitable solvents	1850:1866	Thus, the proposed methodology allows identifying suitable solvents or solvent mixtures relevant for solvent-based preparations of pharmaceutical ASD formulations with low experimental effort.
31988034	12	29	with	formulations	1950:1961	arg1	effort					1985:1990	low experimental effort	1968:1990	low experimental effort	1968:1990	Thus, the proposed methodology allows identifying suitable solvents or solvent mixtures relevant for solvent-based preparations of pharmaceutical ASD formulations with low experimental effort.
31988034	7	30	from	Based	1133:1137	arg1	experiments					1157:1167	vapor-sorption experiments	1142:1167	vapor-sorption experiments demixing of solvents and polymers	1142:1201	Based on vapor-sorption experiments demixing of solvents and polymers were predicted using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT).
31988034	12	31	theme	ASD	1946:1948	arg1	formulations					1950:1961	pharmaceutical ASD formulations	1931:1961	pharmaceutical ASD formulations with low experimental effort	1931:1990	Thus, the proposed methodology allows identifying suitable solvents or solvent mixtures relevant for solvent-based preparations of pharmaceutical ASD formulations with low experimental effort.
31988034	11	32	theme	solvent-mixture	1715:1729	arg1	composition					1731:1741	solvent-mixture composition	1715:1741	solvent-mixture composition	1715:1741	In addition, the impact of temperature, polymer molecular weight, and solvent-mixture composition on miscibility was successfully predicted using PC-SAFT.
31988034	6	33	theme	ethyl	1097:1101	arg1	acetate					1103:1109	ethyl acetate	1097:1109	ethyl acetate	1097:1109	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	33	theme	ethyl	1097:1101	arg1	solvents					1047:1054	the solvents acetone, dichloromethane (DCM)	1043:1085	the solvents acetone, dichloromethane (DCM)	1043:1085	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	10	34	theme	investigated	1567:1578	arg1	solvents					1580:1587	the investigated solvents	1563:1587	the investigated solvents	1563:1587	DCM, ethanol, methanol, and water were found to be completely miscible with PVP K90, while none of the investigated solvents was appropriate for avoiding immiscibility with HPMCAS.
31988034	12	35	theme	pharmaceutical	1931:1944	arg1	formulations					1950:1961	pharmaceutical ASD formulations	1931:1961	pharmaceutical ASD formulations with low experimental effort	1931:1990	Thus, the proposed methodology allows identifying suitable solvents or solvent mixtures relevant for solvent-based preparations of pharmaceutical ASD formulations with low experimental effort.
31988034	11	36	theme	weight	1703:1708	arg1	impact					1662:1667	the impact	1658:1667	the impact of temperature, polymer molecular weight, and solvent-mixture composition on miscibility	1658:1756	In addition, the impact of temperature, polymer molecular weight, and solvent-mixture composition on miscibility was successfully predicted using PC-SAFT.
31988034	10	37	with	miscible	1526:1533	arg1	PVP					1540:1542	PVP K90	1540:1546	PVP K90	1540:1546	DCM, ethanol, methanol, and water were found to be completely miscible with PVP K90, while none of the investigated solvents was appropriate for avoiding immiscibility with HPMCAS.
31988034	6	38	theme	relevant	866:873	arg1	polymers					875:882	the pharmaceutically relevant polymers	845:882	the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water	845:1130	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	38	theme	relevant	866:873	arg1	poly					884:887	poly	884:887	poly(vinylpyrrolidone) (PVP)	884:911	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	38	theme	relevant	866:873	arg1	poly					914:917	poly	914:917	poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64)	914:962	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	38	theme	relevant	866:873	arg1	126G					1018:1021	hydroxyppropyl methylcellulose acetate succinate 126G	969:1021	hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS)	969:1030	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	2	39	theme	solvent-based	288:300	arg1	processes					302:310	solvent-based processes	288:310	solvent-based processes	288:310	ASDs can be produced via solvent-based processes, where API and polymer are both dissolved in a solvent, followed by a solvent evaporation step (e.g. spray drying).
31988034	12	40	theme	formulations	1950:1961	arg1	preparations					1915:1926	solvent-based preparations	1901:1926	solvent-based preparations of pharmaceutical ASD formulations with low experimental effort	1901:1990	Thus, the proposed methodology allows identifying suitable solvents or solvent mixtures relevant for solvent-based preparations of pharmaceutical ASD formulations with low experimental effort.
31988034	1	41	theme	so-called	215:223	arg1	"					253:253	so-called "amorphous solid dispersions"	215:253	so-called "amorphous solid dispersions" (ASDs)	215:260	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	1	41	theme	so-called	215:223	arg1	ASDs					256:259	ASDs	256:259	ASDs	256:259	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	0	42	theme	polymer/solvent	44:58	arg1	behavior					6:13	Phase behavior	0:13	Phase behavior of pharmaceutically relevant polymer/solvent	0:58	Phase behavior of pharmaceutically relevant polymer/solvent mixtures.
31988034	7	43	theme	Statistical	1244:1254	arg1	Theory					1274:1279	the Perturbed-Chain Statistical Associating Fluid Theory	1224:1279	the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT)	1224:1289	Based on vapor-sorption experiments demixing of solvents and polymers were predicted using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT).
31988034	7	43	theme	Statistical	1244:1254	arg1	PC-SAFT					1282:1288	PC-SAFT	1282:1288	PC-SAFT	1282:1288	Based on vapor-sorption experiments demixing of solvents and polymers were predicted using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT).
31988034	7	44	theme	Associating	1256:1266	arg1	Theory					1274:1279	the Perturbed-Chain Statistical Associating Fluid Theory	1224:1279	the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT)	1224:1289	Based on vapor-sorption experiments demixing of solvents and polymers were predicted using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT).
31988034	7	44	theme	Associating	1256:1266	arg1	PC-SAFT					1282:1288	PC-SAFT	1282:1288	PC-SAFT	1282:1288	Based on vapor-sorption experiments demixing of solvents and polymers were predicted using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT).
31988034	3	45	theme	solvent	543:549	arg1	evaporation					551:561	solvent evaporation	543:561	solvent evaporation	543:561	Aiming at a homogeneous API/polymer formulation, phase separation of the components (API, polymer, solvent) during solvent evaporation must be avoided.
31988034	6	46	dep	polymers	875:882	arg1	PVP					908:910	PVP	908:910	PVP	908:910	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	46	dep	polymers	875:882	arg1	HPMCAS					1024:1029	HPMCAS	1024:1029	HPMCAS	1024:1029	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	46	dep	polymers	875:882	arg1	acetate					945:951	vinylpyrrolidone-co-vinyl acetate	919:951	vinylpyrrolidone-co-vinyl acetate	919:951	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	46	dep	polymers	875:882	arg1	polymers					875:882	the pharmaceutically relevant polymers	845:882	the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water	845:1130	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	46	dep	polymers	875:882	arg1	poly					884:887	poly	884:887	poly(vinylpyrrolidone) (PVP)	884:911	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	46	dep	polymers	875:882	arg1	PVPVA64					955:961	PVPVA64	955:961	PVPVA64	955:961	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	46	dep	polymers	875:882	arg1	vinylpyrrolidone					889:904	vinylpyrrolidone	889:904	vinylpyrrolidone	889:904	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	46	dep	polymers	875:882	arg1	poly					914:917	poly	914:917	poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64)	914:962	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	46	dep	polymers	875:882	arg1	126G					1018:1021	hydroxyppropyl methylcellulose acetate succinate 126G	969:1021	hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS)	969:1030	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	2	47	theme	solvent	382:388	arg1	step					402:405	a solvent evaporation step	380:405	a solvent evaporation step (e.g. spray drying)	380:425	ASDs can be produced via solvent-based processes, where API and polymer are both dissolved in a solvent, followed by a solvent evaporation step (e.g. spray drying).
31988034	0	48	theme	relevant	35:42	arg1	polymer/solvent					44:58	pharmaceutically relevant polymer/solvent	18:58	pharmaceutically relevant polymer/solvent	18:58	Phase behavior of pharmaceutically relevant polymer/solvent mixtures.
31988034	6	49	theme	vinylpyrrolidone-co-vinyl	919:943	arg1	poly					914:917	poly	914:917	poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64)	914:962	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	49	theme	vinylpyrrolidone-co-vinyl	919:943	arg1	acetate					945:951	vinylpyrrolidone-co-vinyl acetate	919:951	vinylpyrrolidone-co-vinyl acetate	919:951	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	8	50	theme	solvent/polymer	1344:1358	arg1	mixtures					1360:1367	all investigated solvent/polymer mixtures	1327:1367	all investigated solvent/polymer mixtures	1327:1367	These were found to be correct for all investigated solvent/polymer mixtures.
31988034	1	51	theme	amorphous	226:234	arg1	"					253:253	so-called "amorphous solid dispersions"	215:253	so-called "amorphous solid dispersions" (ASDs)	215:260	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	1	51	theme	amorphous	226:234	arg1	ASDs					256:259	ASDs	256:259	ASDs	256:259	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	12	52	theme	solvent-based	1901:1913	arg1	preparations					1915:1926	solvent-based preparations	1901:1926	solvent-based preparations of pharmaceutical ASD formulations with low experimental effort	1901:1990	Thus, the proposed methodology allows identifying suitable solvents or solvent mixtures relevant for solvent-based preparations of pharmaceutical ASD formulations with low experimental effort.
31988034	7	53	theme	Perturbed-Chain	1228:1242	arg1	Theory					1274:1279	the Perturbed-Chain Statistical Associating Fluid Theory	1224:1279	the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT)	1224:1289	Based on vapor-sorption experiments demixing of solvents and polymers were predicted using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT).
31988034	7	53	theme	Perturbed-Chain	1228:1242	arg1	PC-SAFT					1282:1288	PC-SAFT	1282:1288	PC-SAFT	1282:1288	Based on vapor-sorption experiments demixing of solvents and polymers were predicted using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT).
31988034	3	54	theme	API/polymer	452:462	arg1	formulation					464:474	a homogeneous API/polymer formulation	438:474	a homogeneous API/polymer formulation	438:474	Aiming at a homogeneous API/polymer formulation, phase separation of the components (API, polymer, solvent) during solvent evaporation must be avoided.
31988034	11	55	theme	composition	1731:1741	arg1	impact					1662:1667	the impact	1658:1667	the impact of temperature, polymer molecular weight, and solvent-mixture composition on miscibility	1658:1756	In addition, the impact of temperature, polymer molecular weight, and solvent-mixture composition on miscibility was successfully predicted using PC-SAFT.
31988034	12	56	theme	proposed	1810:1817	arg1	methodology					1819:1829	the proposed methodology	1806:1829	the proposed methodology	1806:1829	Thus, the proposed methodology allows identifying suitable solvents or solvent mixtures relevant for solvent-based preparations of pharmaceutical ASD formulations with low experimental effort.
31988034	3	57	theme	phase	477:481	arg1	separation					483:492	phase separation	477:492	phase separation of the components (API, polymer, solvent) during solvent evaporation	477:561	Aiming at a homogeneous API/polymer formulation, phase separation of the components (API, polymer, solvent) during solvent evaporation must be avoided.
31988034	3	58	dep	components	501:510	arg1	polymer					518:524	polymer	518:524	polymer	518:524	Aiming at a homogeneous API/polymer formulation, phase separation of the components (API, polymer, solvent) during solvent evaporation must be avoided.
31988034	3	58	dep	components	501:510	arg1	API					513:515	API	513:515	API	513:515	Aiming at a homogeneous API/polymer formulation, phase separation of the components (API, polymer, solvent) during solvent evaporation must be avoided.
31988034	3	58	dep	components	501:510	arg1	solvent					527:533	solvent	527:533	solvent	527:533	Aiming at a homogeneous API/polymer formulation, phase separation of the components (API, polymer, solvent) during solvent evaporation must be avoided.
31988034	11	59	from	impact	1662:1667	arg1	miscibility					1746:1756	miscibility	1746:1756	miscibility	1746:1756	In addition, the impact of temperature, polymer molecular weight, and solvent-mixture composition on miscibility was successfully predicted using PC-SAFT.
31988034	6	60	theme	succinate	1008:1016	arg1	polymers					875:882	the pharmaceutically relevant polymers	845:882	the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water	845:1130	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	60	theme	succinate	1008:1016	arg1	HPMCAS					1024:1029	HPMCAS	1024:1029	HPMCAS	1024:1029	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	60	theme	succinate	1008:1016	arg1	126G					1018:1021	hydroxyppropyl methylcellulose acetate succinate 126G	969:1021	hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS)	969:1030	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	61	dep	solvents	1047:1054	arg1	dichloromethane					1065:1079	dichloromethane	1065:1079	dichloromethane (DCM)	1065:1085	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	61	dep	solvents	1047:1054	arg1	acetone					1056:1062	acetone	1056:1062	acetone	1056:1062	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	1	62	theme	solid	236:240	arg1	"					253:253	so-called "amorphous solid dispersions"	215:253	so-called "amorphous solid dispersions" (ASDs)	215:260	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	1	62	theme	solid	236:240	arg1	ASDs					256:259	ASDs	256:259	ASDs	256:259	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	3	63	theme	components	501:510	arg1	separation					483:492	phase separation	477:492	phase separation of the components (API, polymer, solvent) during solvent evaporation	477:561	Aiming at a homogeneous API/polymer formulation, phase separation of the components (API, polymer, solvent) during solvent evaporation must be avoided.
31988034	3	64	theme	homogeneous	440:450	arg1	formulation					464:474	a homogeneous API/polymer formulation	438:474	a homogeneous API/polymer formulation	438:474	Aiming at a homogeneous API/polymer formulation, phase separation of the components (API, polymer, solvent) during solvent evaporation must be avoided.
31988034	1	65	theme	dispersions	242:252	arg1	"					253:253	so-called "amorphous solid dispersions"	215:253	so-called "amorphous solid dispersions" (ASDs)	215:260	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	1	65	theme	dispersions	242:252	arg1	ASDs					256:259	ASDs	256:259	ASDs	256:259	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	7	66	theme	Fluid	1268:1272	arg1	Theory					1274:1279	the Perturbed-Chain Statistical Associating Fluid Theory	1224:1279	the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT)	1224:1289	Based on vapor-sorption experiments demixing of solvents and polymers were predicted using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT).
31988034	7	66	theme	Fluid	1268:1272	arg1	PC-SAFT					1282:1288	PC-SAFT	1282:1288	PC-SAFT	1282:1288	Based on vapor-sorption experiments demixing of solvents and polymers were predicted using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT).
31988034	8	67	theme	investigated	1331:1342	arg1	mixtures					1360:1367	all investigated solvent/polymer mixtures	1327:1367	all investigated solvent/polymer mixtures	1327:1367	These were found to be correct for all investigated solvent/polymer mixtures.
31988034	6	68	theme	acetate	1000:1006	arg1	polymers					875:882	the pharmaceutically relevant polymers	845:882	the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water	845:1130	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	68	theme	acetate	1000:1006	arg1	HPMCAS					1024:1029	HPMCAS	1024:1029	HPMCAS	1024:1029	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	68	theme	acetate	1000:1006	arg1	126G					1018:1021	hydroxyppropyl methylcellulose acetate succinate 126G	969:1021	hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS)	969:1030	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	1	69	from	ingredients	193:203	arg1	"					253:253	so-called "amorphous solid dispersions"	215:253	so-called "amorphous solid dispersions" (ASDs)	215:260	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	1	69	from	ingredients	193:203	arg1	ASDs					256:259	ASDs	256:259	ASDs	256:259	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	1	70	theme	water-soluble	157:169	arg1	APIs					206:209	APIs	206:209	APIs	206:209	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	1	70	theme	water-soluble	157:169	arg1	ingredients					193:203	active pharmaceutical ingredients	171:203	poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs)	150:260	In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs) in so-called "amorphous solid dispersions" (ASDs).
31988034	6	71	theme	methylcellulose	984:998	arg1	polymers					875:882	the pharmaceutically relevant polymers	845:882	the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water	845:1130	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	71	theme	methylcellulose	984:998	arg1	HPMCAS					1024:1029	HPMCAS	1024:1029	HPMCAS	1024:1029	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31988034	6	71	theme	methylcellulose	984:998	arg1	126G					1018:1021	hydroxyppropyl methylcellulose acetate succinate 126G	969:1021	hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS)	969:1030	Suitable polymer/solvent combinations investigated in this work comprise the pharmaceutically relevant polymers poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA64), and hydroxyppropyl methylcellulose acetate succinate 126G (HPMCAS) as well as the solvents acetone, dichloromethane (DCM), ethanol, ethyl acetate, methanol, and water.
31895545	0	0	theme	Oxidized	79:86	arg1	Nanofibrils					88:98	Oxidized Nanofibrils	79:98	Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid	79:162	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.
31895545	3	1	theme	chemical	603:610	arg1	composition					612:622	chemical composition	603:622	chemical composition	603:622	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	4	2	theme	wet	1017:1019	arg1	spinning					1021:1028	The coaxial wet spinning	1005:1028	The coaxial wet spinning	1005:1028	The coaxial wet spinning yields PIL-free systems carrying on the surface the cellulose II polymorph, which not only enhances the toughness of the filaments but facilities their functionalization.
31895545	3	3	theme	X-ray	754:758	arg1	spectroscopy					760:771	energy-dispersive X-ray spectroscopy	736:771	energy-dispersive X-ray spectroscopy	736:771	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	3	4	theme	CSF	587:589	arg1	morphology					591:600	The CSF morphology	583:600	The CSF morphology	583:600	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	4	5	theme	PIL-free	1037:1044	arg1	systems					1046:1052	PIL-free systems	1037:1052	PIL-free systems carrying on the surface the cellulose II polymorph, which not only enhances the toughness of the filaments but facilities their functionalization	1037:1198	The coaxial wet spinning yields PIL-free systems carrying on the surface the cellulose II polymorph, which not only enhances the toughness of the filaments but facilities their functionalization.
31895545	0	6	from	Liquid	157:162	arg1	Regenerated					125:135	Cellulose II Regenerated	112:135	Cellulose II Regenerated from a Protic Ionic Liquid	112:162	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.
31895545	0	7	theme	Sheathed	100:107	arg1	Nanofibrils					88:98	Oxidized Nanofibrils	79:98	Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid	79:162	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.
31895545	1	8	theme	cellulose	265:273	arg1	shell					256:260	a shell	254:260	a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL)	254:377	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	0	9	theme	Nanofibrils	88:98	arg1	Filaments					66:74	Filaments	66:74	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.	0:163	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.
31895545	3	10	theme	thermal	625:631	arg1	stability					633:641	thermal stability	625:641	thermal stability	625:641	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	3	11	theme	bacterial	965:973	arg1	culturing					980:988	bacterial cell culturing	965:988	bacterial cell culturing	965:988	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	3	12	theme	energy-dispersive	736:752	arg1	spectroscopy					760:771	energy-dispersive X-ray spectroscopy	736:771	energy-dispersive X-ray spectroscopy	736:771	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	0	13	theme	Cellulose	112:120	arg1	Regenerated					125:135	Cellulose II Regenerated	112:135	Cellulose II Regenerated from a Protic Ionic Liquid	112:162	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.
31895545	1	14	theme	protic	353:358	arg1	ionic					360:364	a protic ionic liquid	351:371	a protic ionic liquid (PIL)	351:377	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	1	14	theme	protic	353:358	arg1	PIL					374:376	PIL	374:376	PIL	374:376	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	1	14	theme	protic	353:358	arg1	propionate					323:332	1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH]	288:340	1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et])	288:348	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	3	15	theme	cell	975:978	arg1	culturing					980:988	bacterial cell culturing	965:988	bacterial cell culturing	965:988	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	3	16	theme	thermogravimetric	856:872	arg1	analysis					874:881	thermogravimetric analysis	856:881	thermogravimetric analysis	856:881	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	2	17	theme	continuous	428:437	arg1	CSFs					461:464	CSFs	461:464	CSFs	461:464	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	2	17	theme	continuous	428:437	arg1	filaments					450:458	continuous core-shell filaments	428:458	continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %	428:580	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	1	18	dep	propionate	323:332	arg1	[CO2Et					341:346	[CO2Et	341:346	[CO2Et	341:346	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	3	19	theme	infrared	833:840	arg1	spectroscopy					842:853	infrared spectroscopy	833:853	infrared spectroscopy	833:853	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	1	20	theme	liquid	366:371	arg1	ionic					360:364	a protic ionic liquid	351:371	a protic ionic liquid (PIL)	351:377	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	1	20	theme	liquid	366:371	arg1	PIL					374:376	PIL	374:376	PIL	374:376	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	1	20	theme	liquid	366:371	arg1	propionate					323:332	1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH]	288:340	1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et])	288:348	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	2	21	theme	MJ·m-3	547:552	arg1	dry					512:514	an average dry (and wet) toughness	501:534	dry	512:514	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	2	21	theme	MJ·m-3	547:552	arg1	elongation					558:567	elongation	558:567	elongation of ∼9 (14) %	558:580	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	2	21	theme	MJ·m-3	547:552	arg1	toughness					526:534	an average dry (and wet) toughness	501:534	toughness	526:534	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	2	22	with	tough	477:481	arg1	dry					512:514	an average dry (and wet) toughness	501:534	dry	512:514	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	2	22	with	tough	477:481	arg1	toughness					526:534	an average dry (and wet) toughness	501:534	toughness	526:534	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	2	22	with	tough	477:481	arg1	elongation					558:567	elongation	558:567	elongation of ∼9 (14) %	558:580	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	1	23	theme	TEMPO-oxidized	178:191	arg1	nanocellulose					193:205	TEMPO-oxidized nanocellulose	178:205	TEMPO-oxidized nanocellulose	178:205	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	0	24	theme	Coaxial	0:6	arg1	Spinning					8:15	Coaxial Spinning	0:15	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.	0:163	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.
31895545	4	25	contain	carrying	1054:1061	arg2	polymorph					1095:1103	the cellulose II polymorph	1078:1103	the cellulose II polymorph	1078:1103	The coaxial wet spinning yields PIL-free systems carrying on the surface the cellulose II polymorph, which not only enhances the toughness of the filaments but facilities their functionalization.
31895545	4	25	contain	carrying	1054:1061	arg1	systems					1046:1052	PIL-free systems	1037:1052	PIL-free systems carrying on the surface the cellulose II polymorph, which not only enhances the toughness of the filaments but facilities their functionalization	1037:1198	The coaxial wet spinning yields PIL-free systems carrying on the surface the cellulose II polymorph, which not only enhances the toughness of the filaments but facilities their functionalization.
31895545	2	26	theme	%	580:580	arg1	dry					512:514	an average dry (and wet) toughness	501:534	dry	512:514	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	2	26	theme	%	580:580	arg1	elongation					558:567	elongation	558:567	elongation of ∼9 (14) %	558:580	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	2	26	theme	%	580:580	arg1	toughness					526:534	an average dry (and wet) toughness	501:534	toughness	526:534	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	3	27	theme	pyrolysis	884:892	arg1	spectrometry					918:929	pyrolysis gas chromatography-mass spectrometry	884:929	pyrolysis gas chromatography-mass spectrometry	884:929	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	1	28	theme	nanocellulose	193:205	arg1	Hydrogels					165:173	Hydrogels	165:173	Hydrogels of TEMPO-oxidized nanocellulose	165:205	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	0	29	theme	All-Cellulose	20:32	arg1	Systems					34:40	All-Cellulose Systems	20:40	All-Cellulose Systems	20:40	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.
31895545	3	30	dep	Fourier	815:821	arg1	transform					823:831	transform	823:831	transform infrared spectroscopy	823:853	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	3	31	theme	gas	894:896	arg1	spectrometry					918:929	pyrolysis gas chromatography-mass spectrometry	884:929	pyrolysis gas chromatography-mass spectrometry	884:929	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	2	32	theme	acidic	398:403	arg1	bath					411:414	an acidic water bath	395:414	an acidic water bath	395:414	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	2	33	theme	water	405:409	arg1	bath					411:414	an acidic water bath	395:414	an acidic water bath	395:414	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	1	34	theme	non-5-enium	311:321	arg1	ionic					360:364	a protic ionic liquid	351:371	a protic ionic liquid (PIL)	351:377	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	1	34	theme	non-5-enium	311:321	arg1	propionate					323:332	1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH]	288:340	1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et])	288:348	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	2	35	theme	average	504:510	arg1	dry					512:514	an average dry (and wet) toughness	501:534	dry	512:514	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	4	36	theme	cellulose	1082:1090	arg1	polymorph					1095:1103	the cellulose II polymorph	1078:1103	the cellulose II polymorph	1078:1103	The coaxial wet spinning yields PIL-free systems carrying on the surface the cellulose II polymorph, which not only enhances the toughness of the filaments but facilities their functionalization.
31895545	0	37	theme	Systems	34:40	arg1	Spinning					8:15	Coaxial Spinning	0:15	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.	0:163	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.
31895545	4	38	theme	coaxial	1009:1015	arg1	spinning					1021:1028	The coaxial wet spinning	1005:1028	The coaxial wet spinning	1005:1028	The coaxial wet spinning yields PIL-free systems carrying on the surface the cellulose II polymorph, which not only enhances the toughness of the filaments but facilities their functionalization.
31895545	1	39	theme	dry-jet	227:233	arg1	spinning					239:246	dry-jet wet spinning	227:246	dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL)	227:377	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	2	40	theme	core-shell	439:448	arg1	CSFs					461:464	CSFs	461:464	CSFs	461:464	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	2	40	theme	core-shell	439:448	arg1	filaments					450:458	continuous core-shell filaments	428:458	continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %	428:580	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	3	41	theme	wide-angle	932:941	arg1	scattering					949:958	wide-angle X-ray scattering	932:958	wide-angle X-ray scattering	932:958	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	0	42	theme	Enhanced	46:53	arg1	Toughness					55:63	Enhanced Toughness	46:63	Enhanced Toughness	46:63	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.
31895545	3	43	theme	bacterial	663:671	arg1	activity					673:680	bacterial activity	663:680	bacterial activity	663:680	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	3	44	theme	chromatography-mass	898:916	arg1	spectrometry					918:929	pyrolysis gas chromatography-mass spectrometry	884:929	pyrolysis gas chromatography-mass spectrometry	884:929	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	3	45	theme	nuclear	787:793	arg1	resonance					804:812	liquid-state nuclear magnetic resonance	774:812	liquid-state nuclear magnetic resonance	774:812	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	2	46	theme	wet	521:523	arg1	toughness					526:534	an average dry (and wet) toughness	501:534	toughness	526:534	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	4	47	theme	filaments	1151:1159	arg1	toughness					1134:1142	the toughness	1130:1142	the toughness of the filaments	1130:1159	The coaxial wet spinning yields PIL-free systems carrying on the surface the cellulose II polymorph, which not only enhances the toughness of the filaments but facilities their functionalization.
31895545	3	48	theme	magnetic	795:802	arg1	resonance					804:812	liquid-state nuclear magnetic resonance	774:812	liquid-state nuclear magnetic resonance	774:812	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	1	49	theme	wet	235:237	arg1	spinning					239:246	dry-jet wet spinning	227:246	dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL)	227:377	Hydrogels of TEMPO-oxidized nanocellulose were stabilized for dry-jet wet spinning using a shell of cellulose dissolved in 1,5-diazabicyclo[4.3.0]non-5-enium propionate ([DBNH][CO2Et]), a protic ionic liquid (PIL).
31895545	0	50	from	Sheathed	100:107	arg1	Regenerated					125:135	Cellulose II Regenerated	112:135	Cellulose II Regenerated from a Protic Ionic Liquid	112:162	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.
31895545	0	51	dep	Spinning	8:15	arg1	Filaments					66:74	Filaments	66:74	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.	0:163	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.
31895545	2	52	from	Coagulation	380:390	arg1	bath					411:414	an acidic water bath	395:414	an acidic water bath	395:414	Coagulation in an acidic water bath resulted in continuous core-shell filaments (CSFs) that were tough and flexible with an average dry (and wet) toughness of ∼11 (2) MJ·m-3 and elongation of ∼9 (14) %.
31895545	3	53	theme	liquid-state	774:785	arg1	resonance					804:812	liquid-state nuclear magnetic resonance	774:812	liquid-state nuclear magnetic resonance	774:812	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	0	54	from	Regenerated	125:135	arg1	Sheathed					100:107	Sheathed	100:107	Sheathed	100:107	Coaxial Spinning of All-Cellulose Systems for Enhanced Toughness: Filaments of Oxidized Nanofibrils Sheathed in Cellulose II Regenerated from a Protic Ionic Liquid.
31895545	3	55	theme	X-ray	943:947	arg1	scattering					949:958	wide-angle X-ray scattering	932:958	wide-angle X-ray scattering	932:958	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	3	56	theme	electron	711:718	arg1	microscopy					720:729	scanning electron microscopy	702:729	scanning electron microscopy	702:729	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
31895545	3	57	theme	scanning	702:709	arg1	microscopy					720:729	scanning electron microscopy	702:729	scanning electron microscopy	702:729	The CSF morphology, chemical composition, thermal stability, crystallinity, and bacterial activity were assessed using scanning electron microscopy with energy-dispersive X-ray spectroscopy, liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, pyrolysis gas chromatography-mass spectrometry, wide-angle X-ray scattering, and bacterial cell culturing, respectively.
33785093	7	0	theme	stent	1310:1314	arg1	area					1325:1328	a stent external area	1308:1328	a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects	1308:1425	This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects.
33785093	7	1	theme	vascular	1354:1361	arg1	performance					1368:1378	vascular cell performance	1354:1378	vascular cell performance	1354:1378	This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects.
33785093	4	2	theme	2s	832:833	arg1	peak					835:838	the Cu 2s peak	825:838	the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine	825:947	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	1	3	theme	endothelium	188:198	arg1	regeneration					200:211	Continuous delayed endothelium regeneration	169:211	Continuous delayed endothelium regeneration	169:211	Continuous delayed endothelium regeneration and continues thrombosis development designate a task for coronary artery stent rehabilitation.
33785093	0	4	theme	Viability	99:107	arg1	Study					109:113	Viability Study	99:113	Viability Study for Coronary Vascular Cells	99:141	Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments.
33785093	7	5	from	stage	1299:1303	arg1	area					1325:1328	a stent external area	1308:1328	a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects	1308:1425	This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects.
33785093	7	6	theme	composite	1278:1286	arg1	type					1270:1273	This type	1265:1273	This type of composite	1265:1286	This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects.
33785093	5	7	theme	Cu	1023:1024	arg1	coating					1026:1032	the uniform Cu coating	1011:1032	the uniform Cu coating consisting of multilayer poly-L-lysine on the substrate	1011:1088	The relative surface geomorphology of the chelates displayed the uniform Cu coating consisting of multilayer poly-L-lysine on the substrate.
33785093	2	8	theme	novel	422:426	arg1	chelates					483:490	novel copper intercalated polyurethane heparin/poly-L-lysine chelates	422:490	novel copper intercalated polyurethane heparin/poly-L-lysine chelates	422:490	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	0	9	theme	Coronary	119:126	arg1	Cells					137:141	Coronary Vascular Cells	119:141	Coronary Vascular Cells	119:141	Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments.
33785093	3	10	theme	chelates	623:630	arg1	modifications					559:571	The functional group modifications	538:571	The functional group modifications	538:571	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	3	10	theme	chelates	623:630	arg1	characteristics					585:599	structural characteristics	574:599	structural characteristics	574:599	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	3	10	theme	chelates	623:630	arg1	stability					606:614	stability	606:614	stability	606:614	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	5	11	theme	uniform	1015:1021	arg1	coating					1026:1032	the uniform Cu coating	1011:1032	the uniform Cu coating consisting of multilayer poly-L-lysine on the substrate	1011:1088	The relative surface geomorphology of the chelates displayed the uniform Cu coating consisting of multilayer poly-L-lysine on the substrate.
33785093	6	12	dep	clotting	1220:1227	arg1	assessments					1252:1262	assessments	1252:1262	assessments	1252:1262	The stability and biocompatibility studies indicated the significantly enhanced performance with clot the APTT and TT periods as clotting and cell proliferation assessments.
33785093	7	13	theme	side	1414:1417	arg1	effects					1419:1425	low side effects	1410:1425	low side effects	1410:1425	This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects.
33785093	2	14	theme	cell	341:344	arg1	behavior					346:353	the direct vascular cell behavior	321:353	the direct vascular cell behavior	321:353	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	5	15	theme	surface	963:969	arg1	geomorphology					971:983	The relative surface geomorphology	950:983	The relative surface geomorphology of the chelates	950:999	The relative surface geomorphology of the chelates displayed the uniform Cu coating consisting of multilayer poly-L-lysine on the substrate.
33785093	2	16	dep	aneurysms	356:364	arg1	treatments					366:375	treatments	366:375	treatments	366:375	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	2	16	dep	aneurysms	356:364	arg1	chelates					483:490	novel copper intercalated polyurethane heparin/poly-L-lysine chelates	422:490	novel copper intercalated polyurethane heparin/poly-L-lysine chelates	422:490	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	5	17	theme	relative	954:961	arg1	geomorphology					971:983	The relative surface geomorphology	950:983	The relative surface geomorphology of the chelates	950:999	The relative surface geomorphology of the chelates displayed the uniform Cu coating consisting of multilayer poly-L-lysine on the substrate.
33785093	3	18	theme	structural	574:583	arg1	characteristics					585:599	structural characteristics	574:599	structural characteristics	574:599	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	2	19	theme	vascular	332:339	arg1	behavior					346:353	the direct vascular cell behavior	321:353	the direct vascular cell behavior	321:353	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	5	20	theme	multilayer	1048:1057	arg1	poly-L-lysine					1059:1071	multilayer poly-L-lysine	1048:1071	multilayer poly-L-lysine on the substrate	1048:1088	The relative surface geomorphology of the chelates displayed the uniform Cu coating consisting of multilayer poly-L-lysine on the substrate.
33785093	0	21	theme	Vascular	128:135	arg1	Cells					137:141	Coronary Vascular Cells	119:141	Coronary Vascular Cells	119:141	Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments.
33785093	2	22	theme	direct	325:330	arg1	behavior					346:353	the direct vascular cell behavior	321:353	the direct vascular cell behavior	321:353	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	6	23	theme	cell	1233:1236	arg1	proliferation					1238:1250	cell proliferation	1233:1250	cell proliferation	1233:1250	The stability and biocompatibility studies indicated the significantly enhanced performance with clot the APTT and TT periods as clotting and cell proliferation assessments.
33785093	3	24	theme	functional	542:551	arg1	modifications					559:571	The functional group modifications	538:571	The functional group modifications	538:571	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	7	25	theme	external	1316:1323	arg1	area					1325:1328	a stent external area	1308:1328	a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects	1308:1425	This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects.
33785093	7	26	theme	cell	1363:1366	arg1	performance					1368:1378	vascular cell performance	1354:1378	vascular cell performance	1354:1378	This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects.
33785093	3	27	mod	modifications	559:571	arg3	group					553:557	The functional group modifications	538:571	The functional group modifications	538:571	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	3	27	mod	modifications	559:571	arg1	chelates					623:630	the chelates	619:630	the chelates	619:630	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	5	28	from	poly-L-lysine	1059:1071	arg1	substrate					1080:1088	the substrate	1076:1088	the substrate	1076:1088	The relative surface geomorphology of the chelates displayed the uniform Cu coating consisting of multilayer poly-L-lysine on the substrate.
33785093	0	29	dep	Study	109:113	arg1	Treatments					157:166	Treatments	157:166	Treatments	157:166	Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments.
33785093	6	30	theme	clot	1188:1191	arg1	periods					1209:1215	clot the APTT and TT periods	1188:1215	clot the APTT and TT periods	1188:1215	The stability and biocompatibility studies indicated the significantly enhanced performance with clot the APTT and TT periods as clotting and cell proliferation assessments.
33785093	1	31	theme	thrombosis	227:236	arg1	development					238:248	thrombosis development	227:248	thrombosis development	227:248	Continuous delayed endothelium regeneration and continues thrombosis development designate a task for coronary artery stent rehabilitation.
33785093	0	32	theme	Novel	0:4	arg1	Copper					6:11	Novel Copper	0:11	Novel Copper	0:11	Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments.
33785093	6	33	theme	biocompatibility	1109:1124	arg1	studies					1126:1132	The stability and biocompatibility studies	1091:1132	studies	1126:1132	The stability and biocompatibility studies indicated the significantly enhanced performance with clot the APTT and TT periods as clotting and cell proliferation assessments.
33785093	4	34	from	XPS	855:857	arg1	eV					847:848	932 eV	843:848	932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine	843:947	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	1	35	dep	regeneration	200:211	arg1	development					238:248	thrombosis development	227:248	thrombosis development	227:248	Continuous delayed endothelium regeneration and continues thrombosis development designate a task for coronary artery stent rehabilitation.
33785093	2	36	theme	heparin/poly-L-lysine	461:481	arg1	chelates					483:490	novel copper intercalated polyurethane heparin/poly-L-lysine chelates	422:490	novel copper intercalated polyurethane heparin/poly-L-lysine chelates	422:490	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	0	37	theme	Intercalated	27:38	arg1	Chelates					75:82	Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates	27:82	Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments	27:166	Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments.
33785093	6	38	theme	APTT	1197:1200	arg1	periods					1209:1215	clot the APTT and TT periods	1188:1215	clot the APTT and TT periods	1188:1215	The stability and biocompatibility studies indicated the significantly enhanced performance with clot the APTT and TT periods as clotting and cell proliferation assessments.
33785093	6	39	with	performance	1171:1181	arg1	periods					1209:1215	clot the APTT and TT periods	1188:1215	clot the APTT and TT periods	1188:1215	The stability and biocompatibility studies indicated the significantly enhanced performance with clot the APTT and TT periods as clotting and cell proliferation assessments.
33785093	6	40	theme	TT	1206:1207	arg1	periods					1209:1215	clot the APTT and TT periods	1188:1215	clot the APTT and TT periods	1188:1215	The stability and biocompatibility studies indicated the significantly enhanced performance with clot the APTT and TT periods as clotting and cell proliferation assessments.
33785093	3	41	theme	copper	691:696	arg1	polyurethane					654:665	polyurethane	654:665	polyurethane	654:665	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	3	41	theme	copper	691:696	arg1	stents					753:758	copper intercalated polyurethane heparin/poly-L-lysine coated stents	691:758	copper intercalated polyurethane heparin/poly-L-lysine coated stents	691:758	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	6	42	theme	stability	1095:1103	arg1	studies					1126:1132	The stability and biocompatibility studies	1091:1132	studies	1126:1132	The stability and biocompatibility studies indicated the significantly enhanced performance with clot the APTT and TT periods as clotting and cell proliferation assessments.
33785093	4	43	theme	Cu	829:830	arg1	peak					835:838	the Cu 2s peak	825:838	the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine	825:947	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	1	44	theme	Continuous	169:178	arg1	regeneration					200:211	Continuous delayed endothelium regeneration	169:211	Continuous delayed endothelium regeneration	169:211	Continuous delayed endothelium regeneration and continues thrombosis development designate a task for coronary artery stent rehabilitation.
33785093	0	45	theme	Heparin/Poly-L-Lysine	53:73	arg1	Chelates					75:82	Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates	27:82	Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments	27:166	Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments.
33785093	4	46	theme	copper	789:794	arg1	intercalation					796:808	the copper intercalation	785:808	the copper intercalation	785:808	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	3	47	theme	heparin/poly-L-lysine	724:744	arg1	polyurethane					654:665	polyurethane	654:665	polyurethane	654:665	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	3	47	theme	heparin/poly-L-lysine	724:744	arg1	stents					753:758	copper intercalated polyurethane heparin/poly-L-lysine coated stents	691:758	copper intercalated polyurethane heparin/poly-L-lysine coated stents	691:758	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	3	48	theme	group	553:557	arg1	modifications					559:571	The functional group modifications	538:571	The functional group modifications	538:571	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	0	49	theme	Polyurethane	40:51	arg1	Chelates					75:82	Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates	27:82	Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments	27:166	Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments.
33785093	2	50	theme	copper	428:433	arg1	chelates					483:490	novel copper intercalated polyurethane heparin/poly-L-lysine chelates	422:490	novel copper intercalated polyurethane heparin/poly-L-lysine chelates	422:490	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	5	51	theme	chelates	992:999	arg1	geomorphology					971:983	The relative surface geomorphology	950:983	The relative surface geomorphology of the chelates	950:999	The relative surface geomorphology of the chelates displayed the uniform Cu coating consisting of multilayer poly-L-lysine on the substrate.
33785093	0	52	dep	Chelates	75:82	arg1	Stents					91:96	Coated Stents	84:96	Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments	27:166	Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments.
33785093	0	52	dep	Chelates	75:82	arg1	Study					109:113	Viability Study	99:113	Viability Study for Coronary Vascular Cells	99:141	Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments.
33785093	0	52	dep	Chelates	75:82	arg1	Aneurysms					147:155	Aneurysms	147:155	Aneurysms	147:155	Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments.
33785093	0	53	theme	Coated	84:89	arg1	Stents					91:96	Coated Stents	84:96	Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments	27:166	Novel Copper Nanoparticles Intercalated Polyurethane Heparin/Poly-L-Lysine Chelates Coated Stents: Viability Study for Coronary Vascular Cells and Aneurysms Treatments.
33785093	3	54	theme	intercalated	698:709	arg1	polyurethane					654:665	polyurethane	654:665	polyurethane	654:665	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	3	54	theme	intercalated	698:709	arg1	stents					753:758	copper intercalated polyurethane heparin/poly-L-lysine coated stents	691:758	copper intercalated polyurethane heparin/poly-L-lysine coated stents	691:758	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	7	55	dep	track	1345:1349	arg1	treatments					1394:1403	treatments	1394:1403	treatments with low side effects	1394:1425	This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects.
33785093	2	56	theme	implants	413:420	arg1	aneurysms					356:364	aneurysms	356:364	aneurysms	356:364	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	2	56	theme	implants	413:420	arg1	compatibility					381:393	compatibility	381:393	compatibility of cardiovascular implants	381:420	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	3	57	theme	polyurethane	711:722	arg1	polyurethane					654:665	polyurethane	654:665	polyurethane	654:665	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	3	57	theme	polyurethane	711:722	arg1	stents					753:758	copper intercalated polyurethane heparin/poly-L-lysine coated stents	691:758	copper intercalated polyurethane heparin/poly-L-lysine coated stents	691:758	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	2	58	theme	cardiovascular	398:411	arg1	implants					413:420	cardiovascular implants	398:420	cardiovascular implants	398:420	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	4	59	from	eV	847:848	arg1	peak					835:838	the Cu 2s peak	825:838	the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine	825:947	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	4	59	from	eV	847:848	arg1	cmr					817:819	446 cmr	813:819	446 cmr	813:819	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	7	60	theme	low	1410:1412	arg1	effects					1419:1425	low side effects	1410:1425	low side effects	1410:1425	This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects.
33785093	7	61	with	treatments	1394:1403	arg1	effects					1419:1425	low side effects	1410:1425	low side effects	1410:1425	This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects.
33785093	4	62	theme	copper	905:910	arg1	poly-L-lysine					935:947	poly-L-lysine	935:947	poly-L-lysine	935:947	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	4	62	theme	copper	905:910	arg1	heparin					926:932	polyurethane heparin	913:932	polyurethane heparin	913:932	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	4	62	theme	copper	905:910	arg1	coating					894:900	the successful coating	879:900	the successful coating of copper	879:910	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	3	63	theme	coated	746:751	arg1	polyurethane					654:665	polyurethane	654:665	polyurethane	654:665	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	3	63	theme	coated	746:751	arg1	stents					753:758	copper intercalated polyurethane heparin/poly-L-lysine coated stents	691:758	copper intercalated polyurethane heparin/poly-L-lysine coated stents	691:758	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	3	64	dep	polyurethane	654:665	arg1	poly-L-lysine					676:688	poly-L-lysine	676:688	poly-L-lysine	676:688	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	3	64	dep	polyurethane	654:665	arg1	heparin					667:673	heparin	667:673	heparin	667:673	The functional group modifications, structural characteristics, and stability of the chelates have investigated for polyurethane heparin: poly-L-lysine, copper intercalated polyurethane heparin/poly-L-lysine coated stents.
33785093	1	65	theme	coronary	271:278	arg1	rehabilitation					293:306	coronary artery stent rehabilitation	271:306	coronary artery stent rehabilitation	271:306	Continuous delayed endothelium regeneration and continues thrombosis development designate a task for coronary artery stent rehabilitation.
33785093	4	66	theme	successful	883:892	arg1	poly-L-lysine					935:947	poly-L-lysine	935:947	poly-L-lysine	935:947	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	4	66	theme	successful	883:892	arg1	heparin					926:932	polyurethane heparin	913:932	polyurethane heparin	913:932	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	4	66	theme	successful	883:892	arg1	coating					894:900	the successful coating	879:900	the successful coating of copper	879:910	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	6	67	dep	APTT	1197:1200	arg1	the					1193:1195	the	1193:1195	the	1193:1195	The stability and biocompatibility studies indicated the significantly enhanced performance with clot the APTT and TT periods as clotting and cell proliferation assessments.
33785093	2	68	theme	intercalated	435:446	arg1	chelates					483:490	novel copper intercalated polyurethane heparin/poly-L-lysine chelates	422:490	novel copper intercalated polyurethane heparin/poly-L-lysine chelates	422:490	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	1	69	theme	artery	280:285	arg1	rehabilitation					293:306	coronary artery stent rehabilitation	271:306	coronary artery stent rehabilitation	271:306	Continuous delayed endothelium regeneration and continues thrombosis development designate a task for coronary artery stent rehabilitation.
33785093	7	70	theme	performance	1368:1378	arg1	track					1345:1349	track	1345:1349	track of vascular cell performance	1345:1378	This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects.
33785093	7	70	theme	performance	1368:1378	arg1	aneurysms					1384:1392	aneurysms	1384:1392	aneurysms	1384:1392	This type of composite proposes a stage on a stent external area for discerning track of vascular cell performance and aneurysms treatments with low side effects.
33785093	4	71	theme	polyurethane	913:924	arg1	heparin					926:932	polyurethane heparin	913:932	polyurethane heparin	913:932	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	4	71	theme	polyurethane	913:924	arg1	coating					894:900	the successful coating	879:900	the successful coating of copper	879:910	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	4	72	theme	FTIR	765:768	arg1	results					770:776	The FTIR results	761:776	The FTIR results	761:776	The FTIR results showed the copper intercalation at 446 cmr and the Cu 2s peak at 932 eV from XPS also indicated that the successful coating of copper, polyurethane heparin, poly-L-lysine.
33785093	2	73	theme	polyurethane	448:459	arg1	chelates					483:490	novel copper intercalated polyurethane heparin/poly-L-lysine chelates	422:490	novel copper intercalated polyurethane heparin/poly-L-lysine chelates	422:490	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	1	74	theme	stent	287:291	arg1	rehabilitation					293:306	coronary artery stent rehabilitation	271:306	coronary artery stent rehabilitation	271:306	Continuous delayed endothelium regeneration and continues thrombosis development designate a task for coronary artery stent rehabilitation.
33785093	2	75	dep	treated	492:498	arg1	established					510:520	established	510:520	treated stent has established in this report	492:535	To progress the direct vascular cell behavior, aneurysms treatments and compatibility of cardiovascular implants novel copper intercalated polyurethane heparin/poly-L-lysine chelates treated stent has established in this report.
33785093	1	76	theme	delayed	180:186	arg1	regeneration					200:211	Continuous delayed endothelium regeneration	169:211	Continuous delayed endothelium regeneration	169:211	Continuous delayed endothelium regeneration and continues thrombosis development designate a task for coronary artery stent rehabilitation.
33785093	6	77	theme	enhanced	1162:1169	arg1	performance					1171:1181	the significantly enhanced performance	1144:1181	the significantly enhanced performance with clot the APTT and TT periods	1144:1215	The stability and biocompatibility studies indicated the significantly enhanced performance with clot the APTT and TT periods as clotting and cell proliferation assessments.
32014476	0	0	dep	evaluation	119:128	arg1	Incorporation					0:12	Incorporation	0:12	Incorporation of chitosan/graphene oxide nanocomposite in to the PMMA bone cement	0:80	Incorporation of chitosan/graphene oxide nanocomposite in to the PMMA bone cement: Physical, mechanical and biological evaluation.
32014476	5	1	from	incubation	956:965	arg1	solution					974:981	SBF solution	970:981	SBF solution	970:981	The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution.
32014476	5	2	theme	PMMA	798:801	arg1	cement					808:813	the PMMA bone cement	794:813	the PMMA bone cement	794:813	The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution.
32014476	3	3	theme	PMMA	454:457	arg1	cement					464:469	the PMMA bone cement	450:469	the PMMA bone cement with different percentages	450:496	In this study, after preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder, they were added homogeneously to the PMMA bone cement with different percentages.
32014476	6	4	theme	MG-63	999:1003	arg1	culture					1010:1016	MG-63 cell culture	999:1016	MG-63 cell culture	999:1016	The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement.
32014476	4	5	theme	bending	694:700	arg1	strength					702:709	the bending strength	690:709	the bending strength by 24.0%	690:718	The results showed that the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement cause to increase the compressive strength by 16.2%, the compressive modulus by 69.1% and the bending strength by 24.0%.
32014476	6	6	theme	composite	1110:1118	arg1	cement					1125:1130	25 wt% PMMA-Cs/GO composite bone cement	1092:1130	25 wt% PMMA-Cs/GO composite bone cement	1092:1130	The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement.
32014476	6	7	theme	cell	1047:1050	arg1	viability					1052:1060	cell viability	1047:1060	cell viability	1047:1060	The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement.
32014476	4	8	theme	25 wt	539:543	arg1	powder					569:574	Cs/GO nanocomposite powder	549:574	Cs/GO nanocomposite powder	549:574	The results showed that the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement cause to increase the compressive strength by 16.2%, the compressive modulus by 69.1% and the bending strength by 24.0%.
32014476	4	8	theme	25 wt	539:543	arg1	%					544:544	25 wt%	539:544	25 wt% of Cs/GO nanocomposite powder	539:574	The results showed that the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement cause to increase the compressive strength by 16.2%, the compressive modulus by 69.1% and the bending strength by 24.0%.
32014476	0	9	theme	Physical	83:90	arg1	evaluation					119:128	Physical, mechanical and biological evaluation	83:128	Physical, mechanical and biological evaluation	83:128	Incorporation of chitosan/graphene oxide nanocomposite in to the PMMA bone cement: Physical, mechanical and biological evaluation.
32014476	3	10	with	cement	464:469	arg1	percentages					486:496	different percentages	476:496	different percentages	476:496	In this study, after preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder, they were added homogeneously to the PMMA bone cement with different percentages.
32014476	6	11	theme	PMMA-Cs/GO	1099:1108	arg1	cement					1125:1130	25 wt% PMMA-Cs/GO composite bone cement	1092:1130	25 wt% PMMA-Cs/GO composite bone cement	1092:1130	The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement.
32014476	2	12	theme	many	261:264	arg1	researchers					266:276	many researchers	261:276	many researchers	261:276	The properties of this bone cement have attracted many researchers effort to modify its properties.
32014476	7	13	theme	common	1300:1305	arg1	bone					1318:1321	common commercial bone	1300:1321	common commercial bone	1300:1321	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	4	14	theme	compressive	622:632	arg1	strength					634:641	the compressive strength	618:641	the compressive strength	618:641	The results showed that the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement cause to increase the compressive strength by 16.2%, the compressive modulus by 69.1% and the bending strength by 24.0%.
32014476	6	15	theme	cell	1074:1077	arg1	adhesion					1079:1086	cell adhesion	1074:1086	cell adhesion	1074:1086	The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement.
32014476	1	16	theme	bone	164:167	arg1	types					155:159	the most popular types	138:159	the most popular types of bone cements	138:175	One of the most popular types of bone cements is polymethylmethacrylate (PMMA).
32014476	1	17	theme	types	155:159	arg1	types					155:159	the most popular types	138:159	the most popular types of bone cements	138:175	One of the most popular types of bone cements is polymethylmethacrylate (PMMA).
32014476	1	17	theme	types	155:159	arg1	One					131:133	One	131:133	One	131:133	One of the most popular types of bone cements is polymethylmethacrylate (PMMA).
32014476	0	18	theme	mechanical	93:102	arg1	evaluation					119:128	Physical, mechanical and biological evaluation	83:128	Physical, mechanical and biological evaluation	83:128	Incorporation of chitosan/graphene oxide nanocomposite in to the PMMA bone cement: Physical, mechanical and biological evaluation.
32014476	5	19	theme	bone	803:806	arg1	cement					808:813	the PMMA bone cement	794:813	the PMMA bone cement	794:813	The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution.
32014476	3	20	dep	powder	361:366	arg1	powder					409:414	nanocomposite powder	395:414	nanocomposite powder	395:414	In this study, after preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder, they were added homogeneously to the PMMA bone cement with different percentages.
32014476	3	21	theme	different	476:484	arg1	percentages					486:496	different percentages	476:496	different percentages	476:496	In this study, after preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder, they were added homogeneously to the PMMA bone cement with different percentages.
32014476	4	22	theme	bone	588:591	arg1	cement					593:598	the PMMA bone cement	579:598	the PMMA bone cement	579:598	The results showed that the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement cause to increase the compressive strength by 16.2%, the compressive modulus by 69.1% and the bending strength by 24.0%.
32014476	7	23	theme	physical	1235:1242	arg1	properties					1259:1268	improved mechanical, physical and biological properties	1214:1268	improved mechanical, physical and biological properties	1214:1268	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	6	24	theme	growth	1063:1068	arg1	improvement					1032:1042	the improvement	1028:1042	the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement	1028:1130	The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement.
32014476	7	25	theme	PMMA-Cs/GO	1176:1185	arg1	replacement					1284:1294	a good replacement for common commercial bone cements in orthopedic applications	1277:1356	a good replacement for common commercial bone cements in orthopedic applications	1277:1356	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	7	25	theme	PMMA-Cs/GO	1176:1185	arg1	cement					1202:1207	25 wt% PMMA-Cs/GO composite bone cement	1169:1207	25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties	1169:1268	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	4	26	theme	compressive	657:667	arg1	modulus					669:675	the compressive modulus	653:675	the compressive modulus by 69.1%	653:684	The results showed that the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement cause to increase the compressive strength by 16.2%, the compressive modulus by 69.1% and the bending strength by 24.0%.
32014476	3	27	theme	oxide	384:388	arg1	preparation					332:342	preparation	332:342	preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder	332:414	In this study, after preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder, they were added homogeneously to the PMMA bone cement with different percentages.
32014476	7	28	theme	commercial	1307:1316	arg1	bone					1318:1321	common commercial bone	1300:1321	common commercial bone	1300:1321	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	7	29	theme	orthopedic	1334:1343	arg1	applications					1345:1356	orthopedic applications	1334:1356	orthopedic applications	1334:1356	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	0	30	theme	oxide	35:39	arg1	nanocomposite					41:53	chitosan/graphene oxide nanocomposite	17:53	chitosan/graphene oxide nanocomposite	17:53	Incorporation of chitosan/graphene oxide nanocomposite in to the PMMA bone cement: Physical, mechanical and biological evaluation.
32014476	6	31	theme	%	1097:1097	arg1	cement					1125:1130	25 wt% PMMA-Cs/GO composite bone cement	1092:1130	25 wt% PMMA-Cs/GO composite bone cement	1092:1130	The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement.
32014476	5	32	from	solution	974:981	arg1	4 weeks					945:951	4 weeks	945:951	4 weeks of incubation in SBF solution	945:981	The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution.
32014476	3	33	dep	oxide	384:388	arg1	GO					391:392	GO	391:392	GO	391:392	In this study, after preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder, they were added homogeneously to the PMMA bone cement with different percentages.
32014476	7	34	theme	bone	1197:1200	arg1	replacement					1284:1294	a good replacement for common commercial bone cements in orthopedic applications	1277:1356	a good replacement for common commercial bone cements in orthopedic applications	1277:1356	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	7	34	theme	bone	1197:1200	arg1	cement					1202:1207	25 wt% PMMA-Cs/GO composite bone cement	1169:1207	25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties	1169:1268	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	3	35	theme	chitosan	347:354	arg1	powder					361:366	chitosan (Cs) powder	347:366	chitosan (Cs) powder	347:366	In this study, after preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder, they were added homogeneously to the PMMA bone cement with different percentages.
32014476	0	36	theme	biological	108:117	arg1	evaluation					119:128	Physical, mechanical and biological evaluation	83:128	Physical, mechanical and biological evaluation	83:128	Incorporation of chitosan/graphene oxide nanocomposite in to the PMMA bone cement: Physical, mechanical and biological evaluation.
32014476	1	37	theme	popular	147:153	arg1	types					155:159	the most popular types	138:159	the most popular types of bone cements	138:175	One of the most popular types of bone cements is polymethylmethacrylate (PMMA).
32014476	4	38	theme	powder	569:574	arg1	powder					569:574	Cs/GO nanocomposite powder	549:574	Cs/GO nanocomposite powder	549:574	The results showed that the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement cause to increase the compressive strength by 16.2%, the compressive modulus by 69.1% and the bending strength by 24.0%.
32014476	4	38	theme	powder	569:574	arg1	%					544:544	25 wt%	539:544	25 wt% of Cs/GO nanocomposite powder	539:574	The results showed that the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement cause to increase the compressive strength by 16.2%, the compressive modulus by 69.1% and the bending strength by 24.0%.
32014476	4	39	theme	PMMA	583:586	arg1	cement					593:598	the PMMA bone cement	579:598	the PMMA bone cement	579:598	The results showed that the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement cause to increase the compressive strength by 16.2%, the compressive modulus by 69.1% and the bending strength by 24.0%.
32014476	1	40	dep	bone	164:167	arg1	cements					169:175	cements	169:175	cements	169:175	One of the most popular types of bone cements is polymethylmethacrylate (PMMA).
32014476	7	41	theme	improved	1214:1221	arg1	properties					1259:1268	improved mechanical, physical and biological properties	1214:1268	improved mechanical, physical and biological properties	1214:1268	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	3	42	theme	nanocomposite	395:407	arg1	powder					409:414	nanocomposite powder	395:414	nanocomposite powder	395:414	In this study, after preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder, they were added homogeneously to the PMMA bone cement with different percentages.
32014476	0	43	theme	nanocomposite	41:53	arg1	Incorporation					0:12	Incorporation	0:12	Incorporation of chitosan/graphene oxide nanocomposite in to the PMMA bone cement	0:80	Incorporation of chitosan/graphene oxide nanocomposite in to the PMMA bone cement: Physical, mechanical and biological evaluation.
32014476	3	44	theme	Cs/graphene	372:382	arg1	oxide					384:388	Cs/graphene oxide	372:388	Cs/graphene oxide (GO)	372:393	In this study, after preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder, they were added homogeneously to the PMMA bone cement with different percentages.
32014476	7	45	theme	mechanical	1223:1232	arg1	properties					1259:1268	improved mechanical, physical and biological properties	1214:1268	improved mechanical, physical and biological properties	1214:1268	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	7	46	theme	good	1279:1282	arg1	replacement					1284:1294	a good replacement for common commercial bone cements in orthopedic applications	1277:1356	a good replacement for common commercial bone cements in orthopedic applications	1277:1356	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	7	46	theme	good	1279:1282	arg1	cement					1202:1207	25 wt% PMMA-Cs/GO composite bone cement	1169:1207	25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties	1169:1268	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	7	47	theme	composite	1187:1195	arg1	replacement					1284:1294	a good replacement for common commercial bone cements in orthopedic applications	1277:1356	a good replacement for common commercial bone cements in orthopedic applications	1277:1356	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	7	47	theme	composite	1187:1195	arg1	cement					1202:1207	25 wt% PMMA-Cs/GO composite bone cement	1169:1207	25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties	1169:1268	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	5	48	theme	nanocomposite	770:782	arg1	powder					784:789	Cs/GO nanocomposite powder	764:789	Cs/GO nanocomposite powder	764:789	The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution.
32014476	5	49	theme	obtained	725:732	arg1	results					734:740	The obtained results	721:740	The obtained results	721:740	The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution.
32014476	5	50	theme	maximum	863:869	arg1	temperature					871:881	maximum temperature	863:881	maximum temperature	863:881	The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution.
32014476	6	51	theme	culture	1010:1016	arg1	results					988:994	The results	984:994	The results of MG-63 cell culture	984:1016	The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement.
32014476	7	52	theme	25 wt	1169:1173	arg1	%					1174:1174	%	1174:1174	%	1174:1174	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	3	53	theme	powder	361:366	arg1	preparation					332:342	preparation	332:342	preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder	332:414	In this study, after preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder, they were added homogeneously to the PMMA bone cement with different percentages.
32014476	6	54	theme	adhesion	1079:1086	arg1	improvement					1032:1042	the improvement	1028:1042	the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement	1028:1130	The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement.
32014476	6	55	theme	bone	1120:1123	arg1	cement					1125:1130	25 wt% PMMA-Cs/GO composite bone cement	1092:1130	25 wt% PMMA-Cs/GO composite bone cement	1092:1130	The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement.
32014476	7	56	theme	%	1174:1174	arg1	replacement					1284:1294	a good replacement for common commercial bone cements in orthopedic applications	1277:1356	a good replacement for common commercial bone cements in orthopedic applications	1277:1356	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	7	56	theme	%	1174:1174	arg1	cement					1202:1207	25 wt% PMMA-Cs/GO composite bone cement	1169:1207	25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties	1169:1268	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	6	57	theme	25 wt	1092:1096	arg1	%					1097:1097	%	1097:1097	%	1097:1097	The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement.
32014476	5	58	theme	incubation	956:965	arg1	4 weeks					945:951	4 weeks	945:951	4 weeks of incubation in SBF solution	945:981	The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution.
32014476	2	59	theme	cement	239:244	arg1	properties					215:224	The properties	211:224	The properties of this bone cement	211:244	The properties of this bone cement have attracted many researchers effort to modify its properties.
32014476	5	60	theme	setting	816:822	arg1	time					824:827	setting time	816:827	setting time	816:827	The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution.
32014476	6	61	theme	viability	1052:1060	arg1	improvement					1032:1042	the improvement	1028:1042	the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement	1028:1130	The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement.
32014476	7	62	with	cement	1202:1207	arg1	properties					1259:1268	improved mechanical, physical and biological properties	1214:1268	improved mechanical, physical and biological properties	1214:1268	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	2	63	theme	bone	234:237	arg1	cement					239:244	this bone cement	229:244	this bone cement	229:244	The properties of this bone cement have attracted many researchers effort to modify its properties.
32014476	5	64	from	4 weeks	945:951	arg1	solution					974:981	SBF solution	970:981	SBF solution	970:981	The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution.
32014476	4	65	theme	%	544:544	arg1	addition					527:534	the addition	523:534	the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement	523:598	The results showed that the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement cause to increase the compressive strength by 16.2%, the compressive modulus by 69.1% and the bending strength by 24.0%.
32014476	0	66	theme	bone	70:73	arg1	cement					75:80	the PMMA bone cement	61:80	the PMMA bone cement	61:80	Incorporation of chitosan/graphene oxide nanocomposite in to the PMMA bone cement: Physical, mechanical and biological evaluation.
32014476	5	67	theme	SBF	970:972	arg1	solution					974:981	SBF solution	970:981	SBF solution	970:981	The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution.
32014476	5	68	theme	apatite-like	901:912	arg1	deposition					914:923	apatite-like deposition	901:923	apatite-like deposition	901:923	The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution.
32014476	3	69	theme	bone	459:462	arg1	cement					464:469	the PMMA bone cement	450:469	the PMMA bone cement with different percentages	450:496	In this study, after preparation of chitosan (Cs) powder and Cs/graphene oxide (GO) nanocomposite powder, they were added homogeneously to the PMMA bone cement with different percentages.
32014476	5	70	theme	Cs/GO	764:768	arg1	powder					784:789	Cs/GO nanocomposite powder	764:789	Cs/GO nanocomposite powder	764:789	The obtained results showed that by adding Cs/GO nanocomposite powder to the PMMA bone cement, setting time and injectability were increased, maximum temperature was decreased and apatite-like deposition was increased after 4 weeks of incubation in SBF solution.
32014476	4	71	theme	nanocomposite	555:567	arg1	powder					569:574	Cs/GO nanocomposite powder	549:574	Cs/GO nanocomposite powder	549:574	The results showed that the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement cause to increase the compressive strength by 16.2%, the compressive modulus by 69.1% and the bending strength by 24.0%.
32014476	0	72	theme	PMMA	65:68	arg1	cement					75:80	the PMMA bone cement	61:80	the PMMA bone cement	61:80	Incorporation of chitosan/graphene oxide nanocomposite in to the PMMA bone cement: Physical, mechanical and biological evaluation.
32014476	7	73	theme	biological	1248:1257	arg1	properties					1259:1268	improved mechanical, physical and biological properties	1214:1268	improved mechanical, physical and biological properties	1214:1268	Therefore, it can be concluded that 25 wt% PMMA-Cs/GO composite bone cement with improved mechanical, physical and biological properties can be a good replacement for common commercial bone cements in orthopedic applications.
32014476	0	74	theme	chitosan/graphene	17:33	arg1	nanocomposite					41:53	chitosan/graphene oxide nanocomposite	17:53	chitosan/graphene oxide nanocomposite	17:53	Incorporation of chitosan/graphene oxide nanocomposite in to the PMMA bone cement: Physical, mechanical and biological evaluation.
32014476	6	75	theme	cell	1005:1008	arg1	culture					1010:1016	MG-63 cell culture	999:1016	MG-63 cell culture	999:1016	The results of MG-63 cell culture confirmed the improvement of cell viability, growth and cell adhesion for 25 wt% PMMA-Cs/GO composite bone cement.
32014476	4	76	theme	Cs/GO	549:553	arg1	powder					569:574	Cs/GO nanocomposite powder	549:574	Cs/GO nanocomposite powder	549:574	The results showed that the addition of 25 wt% of Cs/GO nanocomposite powder to the PMMA bone cement cause to increase the compressive strength by 16.2%, the compressive modulus by 69.1% and the bending strength by 24.0%.
32916841	7	0	theme	dielectric	1286:1295	arg1	constant					1297:1304	a high dielectric constant	1279:1304	a high dielectric constant	1279:1304	The study of dielectric permittivity displays that ions with a high dielectric constant are associated with a high concentration of added ions.
32916841	2	1	theme	solar	494:498	arg1	cells					500:504	dye-sensitized solar cells	479:504	dye-sensitized solar cells (DSSC)	479:511	The prepared GPEs were applied to dye-sensitized solar cells (DSSC) to observe the effectiveness of the electrolyte, using mesoporous TiO2, which was sensitized with N3 dye as the sensitizer.
32916841	2	1	theme	solar	494:498	arg1	DSSC					507:510	DSSC	507:510	DSSC	507:510	The prepared GPEs were applied to dye-sensitized solar cells (DSSC) to observe the effectiveness of the electrolyte, using mesoporous TiO2, which was sensitized with N3 dye as the sensitizer.
32916841	6	2	theme	ionic	1033:1037	arg1	conductivity					1039:1050	the ionic conductivity	1029:1050	the ionic conductivity of PhCh-based GPE	1029:1068	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	9	3	theme	mA	1664:1665	arg1	cm-2					1667:1670	20.33 mA cm-2	1658:1670	20.33 mA cm-2	1658:1670	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	6	4	theme	salt	1100:1103	arg1	concentration					1105:1117	salt concentration	1100:1117	salt concentration	1100:1117	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	1	5	theme	doping	387:392	arg1	salt					394:397	a doping salt	385:397	a doping salt	385:397	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	5	theme	doping	387:392	arg1	composition					417:427	a mixed composition	409:427	a mixed composition of iodine (I2)	409:442	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	9	6	with	%	1610:1610	arg1	Jsc					1650:1652	Jsc	1650:1652	Jsc	1650:1652	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	6	with	%	1610:1610	arg1	density					1641:1647	a short circuit current density	1617:1647	a short circuit current density (Jsc) of 20.33 mA cm-2	1617:1670	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	7	dep	%	1610:1610	arg1	voltage					1686:1692	open-circuit voltage	1673:1692	open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1	1673:1783	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	7	dep	%	1610:1610	arg1	conductivity					1750:1761	a conductivity	1748:1761	open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1	1673:1783	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	7	dep	%	1610:1610	arg1	Voc					1695:1697	Voc	1695:1697	Voc	1695:1697	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	1	8	theme	-based	191:196	arg1	GPEs					224:227	GPEs	224:227	GPEs	224:227	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	8	theme	-based	191:196	arg1	electrolytes					210:221	phthaloyl chitosan (PhCh)-based gel polymer electrolytes	166:221	phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs)	166:228	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	2	9	theme	prepared	449:456	arg1	GPEs					458:461	The prepared GPEs	445:461	The prepared GPEs	445:461	The prepared GPEs were applied to dye-sensitized solar cells (DSSC) to observe the effectiveness of the electrolyte, using mesoporous TiO2, which was sensitized with N3 dye as the sensitizer.
32916841	6	10	theme	S	1168:1168	arg1	conductivity					1142:1153	the maximum ionic conductivity	1124:1153	the maximum ionic conductivity (4.94 × 10-2 S cm-1)	1124:1174	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	6	10	theme	S	1168:1168	arg1	cm-1					1170:1173	4.94 × 10-2 S cm-1	1156:1173	4.94 × 10-2 S cm-1	1156:1173	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	1	11	theme	polymer	202:208	arg1	GPEs					224:227	GPEs	224:227	GPEs	224:227	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	11	theme	polymer	202:208	arg1	electrolytes					210:221	phthaloyl chitosan (PhCh)-based gel polymer electrolytes	166:221	phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs)	166:228	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	9	12	theme	various	1521:1527	arg1	content					1529:1535	various content	1521:1535	various content of KI	1521:1541	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	6	13	theme	×	1161:1161	arg1	conductivity					1142:1153	the maximum ionic conductivity	1124:1153	the maximum ionic conductivity (4.94 × 10-2 S cm-1)	1124:1174	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	6	13	theme	×	1161:1161	arg1	cm-1					1170:1173	4.94 × 10-2 S cm-1	1156:1173	4.94 × 10-2 S cm-1	1156:1173	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	1	14	theme	potassium	360:368	arg1	KI					378:379	KI	378:379	KI	378:379	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	14	theme	potassium	360:368	arg1	iodide					370:375	potassium iodide	360:375	potassium iodide (KI)	360:380	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	6	15	theme	GPE	1066:1068	arg1	conductivity					1039:1050	the ionic conductivity	1029:1050	the ionic conductivity of PhCh-based GPE	1029:1068	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	9	16	theme	V	1708:1708	arg1	voltage					1686:1692	open-circuit voltage	1673:1692	open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1	1673:1783	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	16	theme	V	1708:1708	arg1	conductivity					1750:1761	a conductivity	1748:1761	open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1	1673:1783	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	16	theme	V	1708:1708	arg1	Voc					1695:1697	Voc	1695:1697	Voc	1695:1697	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	3	17	theme	redox	685:689	arg1	incorporation					641:653	The incorporation	637:653	The incorporation of the potassium iodide-based redox	637:689	The incorporation of the potassium iodide-based redox couple in a polymer electrolyte is fabricated for dye-sensitized solar cells (DSSCs).
32916841	6	18	theme	ionic	1136:1140	arg1	conductivity					1142:1153	the maximum ionic conductivity	1124:1153	the maximum ionic conductivity (4.94 × 10-2 S cm-1)	1124:1174	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	6	18	theme	ionic	1136:1140	arg1	cm-1					1170:1173	4.94 × 10-2 S cm-1	1156:1173	4.94 × 10-2 S cm-1	1156:1173	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	5	19	theme	GPE	903:905	arg1	systems					907:913	prepared GPE systems	894:913	prepared GPE systems	894:913	The electrical performance of prepared GPE systems have been assessed using electrical impedance spectroscopy (EIS), and dielectric permittivity.
32916841	1	20	theme	present	152:158	arg1	work					160:163	the present work	148:163	the present work	148:163	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	4	21	theme	compositions	791:802	arg1	number					781:786	The number	777:786	The number of compositions	777:802	The number of compositions was based on the chemical equation, which is 1:1 for KI:I2.
32916841	2	22	theme	N3	611:612	arg1	dye					614:616	N3 dye	611:616	N3 dye as the sensitizer	611:634	The prepared GPEs were applied to dye-sensitized solar cells (DSSC) to observe the effectiveness of the electrolyte, using mesoporous TiO2, which was sensitized with N3 dye as the sensitizer.
32916841	6	23	dep	observed	1074:1081	arg1	I2					1214:1215	I2	1214:1215	I2	1214:1215	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	3	24	theme	potassium	662:670	arg1	redox					685:689	the potassium iodide-based redox	658:689	the potassium iodide-based redox	658:689	The incorporation of the potassium iodide-based redox couple in a polymer electrolyte is fabricated for dye-sensitized solar cells (DSSCs).
32916841	0	25	theme	Chitosan-Based	69:82	arg1	Electrolytes					96:107	Modified Chitosan-Based Gel Polymer Electrolytes	60:107	Modified Chitosan-Based Gel Polymer Electrolytes Incorporated with Potassium Iodide	60:142	Characteristics of Dye-Sensitized Solar Cell Assembled from Modified Chitosan-Based Gel Polymer Electrolytes Incorporated with Potassium Iodide.
32916841	9	26	theme	conversion	1558:1567	arg1	efficiency					1569:1578	the highest conversion efficiency	1546:1578	electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained	1497:1600	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	26	theme	conversion	1558:1567	arg1	%					1582:1582	η%	1581:1582	η%	1581:1582	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	3	27	theme	polymer	703:709	arg1	electrolyte					711:721	a polymer electrolyte	701:721	a polymer electrolyte	701:721	The incorporation of the potassium iodide-based redox couple in a polymer electrolyte is fabricated for dye-sensitized solar cells (DSSCs).
32916841	0	28	theme	Polymer	88:94	arg1	Electrolytes					96:107	Modified Chitosan-Based Gel Polymer Electrolytes	60:107	Modified Chitosan-Based Gel Polymer Electrolytes Incorporated with Potassium Iodide	60:142	Characteristics of Dye-Sensitized Solar Cell Assembled from Modified Chitosan-Based Gel Polymer Electrolytes Incorporated with Potassium Iodide.
32916841	1	29	theme	iodide	370:375	arg1	quaternaries					344:355	five quaternaries	339:355	five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2)	339:442	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	30	theme	chitosan	176:183	arg1	GPEs					224:227	GPEs	224:227	GPEs	224:227	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	30	theme	chitosan	176:183	arg1	electrolytes					210:221	phthaloyl chitosan (PhCh)-based gel polymer electrolytes	166:221	phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs)	166:228	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	3	31	theme	solar	756:760	arg1	cells					762:766	dye-sensitized solar cells	741:766	dye-sensitized solar cells (DSSCs)	741:774	The incorporation of the potassium iodide-based redox couple in a polymer electrolyte is fabricated for dye-sensitized solar cells (DSSCs).
32916841	3	31	theme	solar	756:760	arg1	DSSCs					769:773	DSSCs	769:773	DSSCs	769:773	The incorporation of the potassium iodide-based redox couple in a polymer electrolyte is fabricated for dye-sensitized solar cells (DSSCs).
32916841	9	32	dep	I2	1543:1544	arg1	efficiency					1569:1578	the highest conversion efficiency	1546:1578	electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained	1497:1600	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	32	dep	I2	1543:1544	arg1	%					1582:1582	η%	1581:1582	η%	1581:1582	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	5	33	theme	electrical	940:949	arg1	spectroscopy					961:972	electrical impedance spectroscopy	940:972	electrical impedance spectroscopy (EIS)	940:978	The electrical performance of prepared GPE systems have been assessed using electrical impedance spectroscopy (EIS), and dielectric permittivity.
32916841	5	33	theme	electrical	940:949	arg1	EIS					975:977	EIS	975:977	EIS	975:977	The electrical performance of prepared GPE systems have been assessed using electrical impedance spectroscopy (EIS), and dielectric permittivity.
32916841	7	34	theme	ions	1356:1359	arg1	concentration					1333:1345	a high concentration	1326:1345	a high concentration of added ions	1326:1359	The study of dielectric permittivity displays that ions with a high dielectric constant are associated with a high concentration of added ions.
32916841	9	35	theme	0.47	1731:1734	arg1	FF					1724:1725	FF	1724:1725	FF	1724:1725	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	35	theme	0.47	1731:1734	arg1	V					1708:1708	0.37 V	1703:1708	0.37 V	1703:1708	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	35	theme	0.47	1731:1734	arg1	factor					1716:1721	fill factor	1711:1721	fill factor (FF) of 0.47	1711:1734	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	6	36	from	improvement	1014:1024	arg1	conductivity					1039:1050	the ionic conductivity	1029:1050	the ionic conductivity of PhCh-based GPE	1029:1068	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	0	37	theme	Potassium	127:135	arg1	Iodide					137:142	Potassium Iodide	127:142	Potassium Iodide	127:142	Characteristics of Dye-Sensitized Solar Cell Assembled from Modified Chitosan-Based Gel Polymer Electrolytes Incorporated with Potassium Iodide.
32916841	2	38	theme	electrolyte	549:559	arg1	effectiveness					528:540	the effectiveness	524:540	the effectiveness of the electrolyte, using mesoporous TiO2, which was sensitized with N3 dye as the sensitizer	524:634	The prepared GPEs were applied to dye-sensitized solar cells (DSSC) to observe the effectiveness of the electrolyte, using mesoporous TiO2, which was sensitized with N3 dye as the sensitizer.
32916841	0	39	theme	Dye-Sensitized	19:32	arg1	Cell					40:43	Dye-Sensitized Solar Cell	19:43	Dye-Sensitized Solar Cell	19:43	Characteristics of Dye-Sensitized Solar Cell Assembled from Modified Chitosan-Based Gel Polymer Electrolytes Incorporated with Potassium Iodide.
32916841	0	40	theme	Cell	40:43	arg1	Characteristics					0:14	Characteristics	0:14	Characteristics of Dye-Sensitized Solar Cell	0:43	Characteristics of Dye-Sensitized Solar Cell Assembled from Modified Chitosan-Based Gel Polymer Electrolytes Incorporated with Potassium Iodide.
32916841	5	41	theme	dielectric	985:994	arg1	permittivity					996:1007	dielectric permittivity	985:1007	dielectric permittivity	985:1007	The electrical performance of prepared GPE systems have been assessed using electrical impedance spectroscopy (EIS), and dielectric permittivity.
32916841	9	42	theme	2.08	1766:1769	arg1	×					1771:1771	×	1771:1771	×	1771:1771	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	6	43	theme	KI	1211:1212	arg1	mol					1204:1206	the 0.0012 mol	1193:1206	the 0.0012 mol of KI	1193:1212	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	9	44	theme	short	1619:1623	arg1	Jsc					1650:1652	Jsc	1650:1652	Jsc	1650:1652	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	44	theme	short	1619:1623	arg1	density					1641:1647	a short circuit current density	1617:1647	a short circuit current density (Jsc) of 20.33 mA cm-2	1617:1670	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	8	45	theme	gel	1379:1381	arg1	samples					1403:1409	the gel polymer electrolyte samples	1375:1409	the gel polymer electrolyte samples	1375:1409	Furthermore, the gel polymer electrolyte samples were applied to DSSCs to detect the conversion effectiveness of the electrolytes.
32916841	9	46	theme	10-2	1773:1776	arg1	cm-1					1780:1783	2.08 × 10-2 S cm-1	1766:1783	2.08 × 10-2 S cm-1	1766:1783	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	47	contain	containing	1510:1519	arg1	electrolytes					1497:1508	electrolytes	1497:1508	electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained	1497:1600	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	47	contain	containing	1510:1519	arg2	content					1529:1535	various content	1521:1535	various content of KI	1521:1541	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	48	theme	current	1633:1639	arg1	Jsc					1650:1652	Jsc	1650:1652	Jsc	1650:1652	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	48	theme	current	1633:1639	arg1	density					1641:1647	a short circuit current density	1617:1647	a short circuit current density (Jsc) of 20.33 mA cm-2	1617:1670	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	8	49	theme	electrolyte	1391:1401	arg1	samples					1403:1409	the gel polymer electrolyte samples	1375:1409	the gel polymer electrolyte samples	1375:1409	Furthermore, the gel polymer electrolyte samples were applied to DSSCs to detect the conversion effectiveness of the electrolytes.
32916841	9	50	theme	cm-1	1780:1783	arg1	voltage					1686:1692	open-circuit voltage	1673:1692	open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1	1673:1783	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	50	theme	cm-1	1780:1783	arg1	conductivity					1750:1761	a conductivity	1748:1761	open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1	1673:1783	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	50	theme	cm-1	1780:1783	arg1	Voc					1695:1697	Voc	1695:1697	Voc	1695:1697	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	1	51	theme	iodine	432:437	arg1	salt					394:397	a doping salt	385:397	a doping salt	385:397	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	51	theme	iodine	432:437	arg1	composition					417:427	a mixed composition	409:427	a mixed composition of iodine (I2)	409:442	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	7	52	with	ions	1269:1272	arg1	constant					1297:1304	a high dielectric constant	1279:1304	a high dielectric constant	1279:1304	The study of dielectric permittivity displays that ions with a high dielectric constant are associated with a high concentration of added ions.
32916841	7	53	theme	high	1281:1284	arg1	constant					1297:1304	a high dielectric constant	1279:1304	a high dielectric constant	1279:1304	The study of dielectric permittivity displays that ions with a high dielectric constant are associated with a high concentration of added ions.
32916841	9	54	theme	fill	1711:1714	arg1	FF					1724:1725	FF	1724:1725	FF	1724:1725	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	54	theme	fill	1711:1714	arg1	V					1708:1708	0.37 V	1703:1708	0.37 V	1703:1708	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	54	theme	fill	1711:1714	arg1	factor					1716:1721	fill factor	1711:1721	fill factor (FF) of 0.47	1711:1734	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	6	55	theme	maximum	1128:1134	arg1	conductivity					1142:1153	the maximum ionic conductivity	1124:1153	the maximum ionic conductivity (4.94 × 10-2 S cm-1)	1124:1174	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	6	55	theme	maximum	1128:1134	arg1	cm-1					1170:1173	4.94 × 10-2 S cm-1	1156:1173	4.94 × 10-2 S cm-1	1156:1173	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	4	56	dep	KI	857:858	arg1	I2					860:861	I2	860:861	KI:I2	857:861	The number of compositions was based on the chemical equation, which is 1:1 for KI:I2.
32916841	2	57	theme	dye-sensitized	479:492	arg1	cells					500:504	dye-sensitized solar cells	479:504	dye-sensitized solar cells (DSSC)	479:511	The prepared GPEs were applied to dye-sensitized solar cells (DSSC) to observe the effectiveness of the electrolyte, using mesoporous TiO2, which was sensitized with N3 dye as the sensitizer.
32916841	2	57	theme	dye-sensitized	479:492	arg1	DSSC					507:510	DSSC	507:510	DSSC	507:510	The prepared GPEs were applied to dye-sensitized solar cells (DSSC) to observe the effectiveness of the electrolyte, using mesoporous TiO2, which was sensitized with N3 dye as the sensitizer.
32916841	7	58	theme	dielectric	1231:1240	arg1	permittivity					1242:1253	dielectric permittivity	1231:1253	dielectric permittivity	1231:1253	The study of dielectric permittivity displays that ions with a high dielectric constant are associated with a high concentration of added ions.
32916841	9	59	theme	20.33	1658:1662	arg1	cm-2					1667:1670	20.33 mA cm-2	1658:1670	20.33 mA cm-2	1658:1670	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	6	60	theme	concentration	1105:1117	arg1	rise					1092:1095	the rise	1088:1095	the rise of salt concentration	1088:1117	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	7	61	theme	permittivity	1242:1253	arg1	study					1222:1226	The study	1218:1226	The study of dielectric permittivity	1218:1253	The study of dielectric permittivity displays that ions with a high dielectric constant are associated with a high concentration of added ions.
32916841	9	62	theme	cm-2	1667:1670	arg1	Jsc					1650:1652	Jsc	1650:1652	Jsc	1650:1652	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	62	theme	cm-2	1667:1670	arg1	density					1641:1647	a short circuit current density	1617:1647	a short circuit current density (Jsc) of 20.33 mA cm-2	1617:1670	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	63	theme	open-circuit	1673:1684	arg1	voltage					1686:1692	open-circuit voltage	1673:1692	open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1	1673:1783	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	63	theme	open-circuit	1673:1684	arg1	Voc					1695:1697	Voc	1695:1697	Voc	1695:1697	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	1	64	theme	gel	198:200	arg1	GPEs					224:227	GPEs	224:227	GPEs	224:227	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	64	theme	gel	198:200	arg1	electrolytes					210:221	phthaloyl chitosan (PhCh)-based gel polymer electrolytes	166:221	phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs)	166:228	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	6	65	theme	10-2	1163:1166	arg1	conductivity					1142:1153	the maximum ionic conductivity	1124:1153	the maximum ionic conductivity (4.94 × 10-2 S cm-1)	1124:1174	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	6	65	theme	10-2	1163:1166	arg1	cm-1					1170:1173	4.94 × 10-2 S cm-1	1156:1173	4.94 × 10-2 S cm-1	1156:1173	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	6	66	theme	4.94	1156:1159	arg1	conductivity					1142:1153	the maximum ionic conductivity	1124:1153	the maximum ionic conductivity (4.94 × 10-2 S cm-1)	1124:1174	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	6	66	theme	4.94	1156:1159	arg1	cm-1					1170:1173	4.94 × 10-2 S cm-1	1156:1173	4.94 × 10-2 S cm-1	1156:1173	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	1	67	theme	quaternaries	344:355	arg1	dimethylformamide					250:266	dimethylformamide	250:266	dimethylformamide (DMF)	250:272	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	67	theme	quaternaries	344:355	arg1	set					332:334	a set	330:334	a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2)	330:442	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	67	theme	quaternaries	344:355	arg1	quaternaries					344:355	five quaternaries	339:355	five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2)	339:442	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	67	theme	quaternaries	344:355	arg1	co-solvent					314:323	a co-solvent	312:323	a co-solvent	312:323	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	9	68	theme	KI	1540:1541	arg1	content					1529:1535	various content	1521:1535	various content of KI	1521:1541	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	5	69	theme	prepared	894:901	arg1	systems					907:913	prepared GPE systems	894:913	prepared GPE systems	894:913	The electrical performance of prepared GPE systems have been assessed using electrical impedance spectroscopy (EIS), and dielectric permittivity.
32916841	3	70	theme	dye-sensitized	741:754	arg1	cells					762:766	dye-sensitized solar cells	741:766	dye-sensitized solar cells (DSSCs)	741:774	The incorporation of the potassium iodide-based redox couple in a polymer electrolyte is fabricated for dye-sensitized solar cells (DSSCs).
32916841	3	70	theme	dye-sensitized	741:754	arg1	DSSCs					769:773	DSSCs	769:773	DSSCs	769:773	The incorporation of the potassium iodide-based redox couple in a polymer electrolyte is fabricated for dye-sensitized solar cells (DSSCs).
32916841	6	71	theme	PhCh-based	1055:1064	arg1	GPE					1066:1068	PhCh-based GPE	1055:1068	PhCh-based GPE	1055:1068	The improvement in the ionic conductivity of PhCh-based GPE was observed with the rise of salt concentration, and the maximum ionic conductivity (4.94 × 10-2 S cm-1) was achieved for the 0.0012 mol of KI:I2.
32916841	0	72	theme	Gel	84:86	arg1	Electrolytes					96:107	Modified Chitosan-Based Gel Polymer Electrolytes	60:107	Modified Chitosan-Based Gel Polymer Electrolytes Incorporated with Potassium Iodide	60:142	Characteristics of Dye-Sensitized Solar Cell Assembled from Modified Chitosan-Based Gel Polymer Electrolytes Incorporated with Potassium Iodide.
32916841	5	73	theme	systems	907:913	arg1	performance					879:889	The electrical performance	864:889	The electrical performance of prepared GPE systems	864:913	The electrical performance of prepared GPE systems have been assessed using electrical impedance spectroscopy (EIS), and dielectric permittivity.
32916841	9	74	theme	highest	1550:1556	arg1	efficiency					1569:1578	the highest conversion efficiency	1546:1578	electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained	1497:1600	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	74	theme	highest	1550:1556	arg1	%					1582:1582	η%	1581:1582	η%	1581:1582	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	3	75	theme	iodide-based	672:683	arg1	redox					685:689	the potassium iodide-based redox	658:689	the potassium iodide-based redox	658:689	The incorporation of the potassium iodide-based redox couple in a polymer electrolyte is fabricated for dye-sensitized solar cells (DSSCs).
32916841	9	76	dep	electrolytes	1497:1508	arg1	I2					1543:1544	I2 the highest conversion efficiency (η%)	1543:1583	electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained	1497:1600	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	1	77	theme	phthaloyl	166:174	arg1	PhCh					186:189	PhCh	186:189	PhCh	186:189	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	77	theme	phthaloyl	166:174	arg1	chitosan					176:183	phthaloyl chitosan	166:183	phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs)	166:228	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	7	78	theme	added	1350:1354	arg1	ions					1356:1359	added ions	1350:1359	added ions	1350:1359	The study of dielectric permittivity displays that ions with a high dielectric constant are associated with a high concentration of added ions.
32916841	5	79	theme	impedance	951:959	arg1	spectroscopy					961:972	electrical impedance spectroscopy	940:972	electrical impedance spectroscopy (EIS)	940:978	The electrical performance of prepared GPE systems have been assessed using electrical impedance spectroscopy (EIS), and dielectric permittivity.
32916841	5	79	theme	impedance	951:959	arg1	EIS					975:977	EIS	975:977	EIS	975:977	The electrical performance of prepared GPE systems have been assessed using electrical impedance spectroscopy (EIS), and dielectric permittivity.
32916841	4	80	theme	chemical	821:828	arg1	equation					830:837	the chemical equation	817:837	the chemical equation	817:837	The number of compositions was based on the chemical equation, which is 1:1 for KI:I2.
32916841	4	80	theme	chemical	821:828	arg1	1:1					849:851	1:1	849:851	1:1	849:851	The number of compositions was based on the chemical equation, which is 1:1 for KI:I2.
32916841	2	81	theme	mesoporous	568:577	arg1	TiO2					579:582	mesoporous TiO2	568:582	mesoporous TiO2	568:582	The prepared GPEs were applied to dye-sensitized solar cells (DSSC) to observe the effectiveness of the electrolyte, using mesoporous TiO2, which was sensitized with N3 dye as the sensitizer.
32916841	9	82	theme	DSSC	1588:1591	arg1	I2					1543:1544	I2 the highest conversion efficiency (η%)	1543:1583	electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained	1497:1600	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	0	83	theme	Solar	34:38	arg1	Cell					40:43	Dye-Sensitized Solar Cell	19:43	Dye-Sensitized Solar Cell	19:43	Characteristics of Dye-Sensitized Solar Cell Assembled from Modified Chitosan-Based Gel Polymer Electrolytes Incorporated with Potassium Iodide.
32916841	0	84	theme	Modified	60:67	arg1	Electrolytes					96:107	Modified Chitosan-Based Gel Polymer Electrolytes	60:107	Modified Chitosan-Based Gel Polymer Electrolytes Incorporated with Potassium Iodide	60:142	Characteristics of Dye-Sensitized Solar Cell Assembled from Modified Chitosan-Based Gel Polymer Electrolytes Incorporated with Potassium Iodide.
32916841	1	85	theme	ethyl	288:292	arg1	EC					305:306	EC	305:306	EC	305:306	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	85	theme	ethyl	288:292	arg1	solvent					279:285	a solvent	277:285	a solvent	277:285	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	85	theme	ethyl	288:292	arg1	carbonate					294:302	ethyl carbonate	288:302	ethyl carbonate (EC)	288:307	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	7	86	theme	high	1328:1331	arg1	concentration					1333:1345	a high concentration	1326:1345	a high concentration of added ions	1326:1359	The study of dielectric permittivity displays that ions with a high dielectric constant are associated with a high concentration of added ions.
32916841	5	87	theme	electrical	868:877	arg1	performance					879:889	The electrical performance	864:889	The electrical performance of prepared GPE systems	864:913	The electrical performance of prepared GPE systems have been assessed using electrical impedance spectroscopy (EIS), and dielectric permittivity.
32916841	8	88	theme	polymer	1383:1389	arg1	samples					1403:1409	the gel polymer electrolyte samples	1375:1409	the gel polymer electrolyte samples	1375:1409	Furthermore, the gel polymer electrolyte samples were applied to DSSCs to detect the conversion effectiveness of the electrolytes.
32916841	9	89	theme	×	1771:1771	arg1	cm-1					1780:1783	2.08 × 10-2 S cm-1	1766:1783	2.08 × 10-2 S cm-1	1766:1783	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	1	90	theme	mixed	411:415	arg1	salt					394:397	a doping salt	385:397	a doping salt	385:397	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	1	90	theme	mixed	411:415	arg1	composition					417:427	a mixed composition	409:427	a mixed composition of iodine (I2)	409:442	In the present work, phthaloyl chitosan (PhCh)-based gel polymer electrolytes (GPEs) were prepared using dimethylformamide (DMF) as a solvent, ethyl carbonate (EC) as a co-solvent, and a set of five quaternaries of potassium iodide (KI) as a doping salt, which is a mixed composition of iodine (I2).
32916841	8	91	theme	conversion	1447:1456	arg1	effectiveness					1458:1470	the conversion effectiveness	1443:1470	the conversion effectiveness of the electrolytes	1443:1490	Furthermore, the gel polymer electrolyte samples were applied to DSSCs to detect the conversion effectiveness of the electrolytes.
32916841	9	92	theme	circuit	1625:1631	arg1	Jsc					1650:1652	Jsc	1650:1652	Jsc	1650:1652	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	92	theme	circuit	1625:1631	arg1	density					1641:1647	a short circuit current density	1617:1647	a short circuit current density (Jsc) of 20.33 mA cm-2	1617:1670	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	9	93	theme	S	1778:1778	arg1	cm-1					1780:1783	2.08 × 10-2 S cm-1	1766:1783	2.08 × 10-2 S cm-1	1766:1783	For electrolytes containing various content of KI:I2 the highest conversion efficiency (η%) of DSSC obtained was 3.57% with a short circuit current density (Jsc) of 20.33 mA cm-2, open-circuit voltage (Voc) of 0.37 V, fill factor (FF) of 0.47, as well as a conductivity of 2.08 × 10-2 S cm-1.
32916841	8	94	theme	electrolytes	1479:1490	arg1	effectiveness					1458:1470	the conversion effectiveness	1443:1470	the conversion effectiveness of the electrolytes	1443:1490	Furthermore, the gel polymer electrolyte samples were applied to DSSCs to detect the conversion effectiveness of the electrolytes.
32466615	0	0	theme	Extract	84:90	arg1	Properties					33:42	Prebiotic Properties	23:42	Prebiotic Properties of a Commercial Artichoke Inflorescence Extract	23:90	In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract Revealed Bifidogenic Effects.
32466615	11	1	theme	bifidogenic	1450:1460	arg1	effects					1462:1468	bifidogenic effects	1450:1468	bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE	1450:1579	Lactate levels initially increased but branched SCFA and ammonium levels remained low till 48 h. CONCLUSION AADE displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE.
32466615	10	2	theme	SCFA	1225:1228	arg1	production					1230:1239	total SCFA production	1219:1239	total SCFA production	1219:1239	Acetate, propionate, and total SCFA production increased significantly with both at all time-points.
32466615	9	3	dep	increased	1147:1155	arg1	till					1171:1174	till	1171:1174	till	1171:1174	At 6 h, pH decreased with AADE and FOS and remained stable until 48 h; however, gas pressure increased significantly till the end of study.
32466615	3	4	theme	colonic	470:476	arg1	fermentations					478:490	Short-term colonic fermentations	459:490	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank	451:549	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank were performed.
32466615	3	4	theme	colonic	470:476	arg1	h					496:496	48 h	493:496	48 h	493:496	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank were performed.
32466615	6	5	dep	RESULTS	797:803	arg1	increased					860:868	increased	860:868	increased 25-fold with AADE (p < 0.05) and >100-fold with FOS (p < 0.05)	860:931	RESULTS After 24 and 48 h of incubation, bifidobacteria levels increased 25-fold with AADE (p < 0.05) and >100-fold with FOS (p < 0.05) compared to blank.
32466615	0	6	theme	Inflorescence	70:82	arg1	Extract					84:90	a Commercial Artichoke Inflorescence Extract	47:90	a Commercial Artichoke Inflorescence Extract	47:90	In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract Revealed Bifidogenic Effects.
32466615	10	7	theme	total	1219:1223	arg1	production					1230:1239	total SCFA production	1219:1239	total SCFA production	1219:1239	Acetate, propionate, and total SCFA production increased significantly with both at all time-points.
32466615	5	8	theme	targeted	781:788	arg1	qPCRs					790:794	targeted qPCRs	781:794	targeted qPCRs	781:794	Community composition was assessed via targeted qPCRs.
32466615	1	9	theme	dietary	157:163	arg1	supplement					165:174	a dietary supplement	155:174	a dietary supplement	155:174	: Background: Prebiotics used as a dietary supplement, stimulate health-related gut microbiota (e.g., bifidobacteria, lactobacilli, etc.).
32466615	0	10	theme	Bifidogenic	101:111	arg1	Effects					113:119	Bifidogenic Effects	101:119	Bifidogenic Effects	101:119	In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract Revealed Bifidogenic Effects.
32466615	11	11	dep	remained	1368:1375	arg1	displayed					1408:1416	displayed	1408:1416	displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE	1408:1579	Lactate levels initially increased but branched SCFA and ammonium levels remained low till 48 h. CONCLUSION AADE displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE.
32466615	4	12	theme	gas	665:667	arg1	pH					661:662	pH	661:662	pH	661:662	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	4	12	theme	gas	665:667	arg1	pressure					669:676	gas pressure	665:676	gas pressure	665:676	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	2	13	theme	potential	282:290	arg1	effects					302:308	potential prebiotic effects	282:308	potential prebiotic effects of an artichoke aqueous dry extract (AADE)	282:351	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	3	14	theme	AADE	502:505	arg1	METHODS					451:457	METHODS	451:457	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank	451:549	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank were performed.
32466615	9	15	dep	decreased	1065:1073	arg1	increased					1147:1155	increased	1147:1155	increased significantly till the end of study	1147:1191	At 6 h, pH decreased with AADE and FOS and remained stable until 48 h; however, gas pressure increased significantly till the end of study.
32466615	9	16	theme	gas	1134:1136	arg1	pressure					1138:1145	gas pressure	1134:1145	gas pressure	1134:1145	At 6 h, pH decreased with AADE and FOS and remained stable until 48 h; however, gas pressure increased significantly till the end of study.
32466615	3	17	dep	METHODS	451:457	arg1	fermentations					478:490	Short-term colonic fermentations	459:490	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank	451:549	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank were performed.
32466615	3	17	dep	METHODS	451:457	arg1	h					496:496	48 h	493:496	48 h	493:496	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank were performed.
32466615	2	18	theme	gut	368:370	arg1	model					372:376	in vitro gut model	359:376	in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®)	359:448	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	2	19	theme	Human	404:408	arg1	Ecosystem					431:439	Human Intestinal Microbial Ecosystem	404:439	Human Intestinal Microbial Ecosystem (SHIME®)	404:448	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	2	19	theme	Human	404:408	arg1	SHIME®					442:447	SHIME®	442:447	SHIME®	442:447	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	5	20	theme	Community	742:750	arg1	composition					752:762	Community composition	742:762	Community composition	742:762	Community composition was assessed via targeted qPCRs.
32466615	2	21	theme	Intestinal	410:419	arg1	Ecosystem					431:439	Human Intestinal Microbial Ecosystem	404:439	Human Intestinal Microbial Ecosystem (SHIME®)	404:448	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	2	21	theme	Intestinal	410:419	arg1	SHIME®					442:447	SHIME®	442:447	SHIME®	442:447	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	6	22	theme	incubation	826:835	arg1	h					821:821	24 and 48 h	811:821	24 and 48 h of incubation	811:835	RESULTS After 24 and 48 h of incubation, bifidobacteria levels increased 25-fold with AADE (p < 0.05) and >100-fold with FOS (p < 0.05) compared to blank.
32466615	2	23	theme	in	359:360	arg1	model					372:376	in vitro gut model	359:376	in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®)	359:448	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	0	24	theme	In	0:1	arg1	Evaluation					9:18	In Vitro Evaluation	0:18	In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract	0:90	In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract Revealed Bifidogenic Effects.
32466615	3	25	theme	fructo-oligosaccharides	508:530	arg1	METHODS					451:457	METHODS	451:457	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank	451:549	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank were performed.
32466615	4	26	theme	incubation	636:645	arg1	h					623:623	0, 6, 24, and 48 h	606:623	0, 6, 24, and 48 h of colonic incubation	606:645	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	1	27	theme	health-related	187:200	arg1	microbiota					206:215	health-related gut microbiota	187:215	health-related gut microbiota (e.g., bifidobacteria, lactobacilli, etc.)	187:258	: Background: Prebiotics used as a dietary supplement, stimulate health-related gut microbiota (e.g., bifidobacteria, lactobacilli, etc.).
32466615	6	28	theme	bifidobacteria	838:851	arg1	levels					853:858	bifidobacteria levels	838:858	bifidobacteria levels	838:858	RESULTS After 24 and 48 h of incubation, bifidobacteria levels increased 25-fold with AADE (p < 0.05) and >100-fold with FOS (p < 0.05) compared to blank.
32466615	11	29	theme	ammonium	1352:1359	arg1	levels					1361:1366	branched SCFA and ammonium levels	1334:1366	levels	1361:1366	Lactate levels initially increased but branched SCFA and ammonium levels remained low till 48 h. CONCLUSION AADE displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE.
32466615	2	30	theme	prebiotic	292:300	arg1	effects					302:308	potential prebiotic effects	282:308	potential prebiotic effects of an artichoke aqueous dry extract (AADE)	282:351	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	11	31	theme	branched	1334:1341	arg1	SCFA					1343:1346	branched SCFA and ammonium levels	1334:1366	SCFA	1343:1346	Lactate levels initially increased but branched SCFA and ammonium levels remained low till 48 h. CONCLUSION AADE displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE.
32466615	1	32	theme	gut	202:204	arg1	microbiota					206:215	health-related gut microbiota	187:215	health-related gut microbiota (e.g., bifidobacteria, lactobacilli, etc.)	187:258	: Background: Prebiotics used as a dietary supplement, stimulate health-related gut microbiota (e.g., bifidobacteria, lactobacilli, etc.).
32466615	4	33	theme	ammonium	688:695	arg1	levels					734:739	lactate, ammonium, and short-chain fatty acids (SCFAs) levels	679:739	lactate, ammonium, and short-chain fatty acids (SCFAs) levels	679:739	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	4	33	theme	ammonium	688:695	arg1	pH					661:662	pH	661:662	pH	661:662	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	11	34	theme	microbial	1515:1523	arg1	metabolites					1525:1535	health-related microbial metabolites	1500:1535	health-related microbial metabolites	1500:1535	Lactate levels initially increased but branched SCFA and ammonium levels remained low till 48 h. CONCLUSION AADE displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE.
32466615	2	35	theme	extract	338:344	arg1	effects					302:308	potential prebiotic effects	282:308	potential prebiotic effects of an artichoke aqueous dry extract (AADE)	282:351	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	4	36	theme	Microbial	567:575	arg1	metabolites					577:587	Microbial metabolites	567:587	Microbial metabolites	567:587	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	0	37	theme	Properties	33:42	arg1	Evaluation					9:18	In Vitro Evaluation	0:18	In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract	0:90	In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract Revealed Bifidogenic Effects.
32466615	3	38	theme	Short-term	459:468	arg1	fermentations					478:490	Short-term colonic fermentations	459:490	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank	451:549	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank were performed.
32466615	3	38	theme	Short-term	459:468	arg1	h					496:496	48 h	493:496	48 h	493:496	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank were performed.
32466615	11	39	theme	metabolites	1525:1535	arg1	production					1486:1495	production	1486:1495	production	1486:1495	Lactate levels initially increased but branched SCFA and ammonium levels remained low till 48 h. CONCLUSION AADE displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE.
32466615	4	40	theme	short-chain	702:712	arg1	SCFAs					727:731	SCFAs	727:731	SCFAs	727:731	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	4	40	theme	short-chain	702:712	arg1	acids					720:724	short-chain fatty acids	702:724	short-chain fatty acids (SCFAs)	702:732	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	0	41	theme	Prebiotic	23:31	arg1	Properties					33:42	Prebiotic Properties	23:42	Prebiotic Properties of a Commercial Artichoke Inflorescence Extract	23:90	In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract Revealed Bifidogenic Effects.
32466615	2	42	theme	Ecosystem	431:439	arg1	Simulator					391:399	the Simulator	387:399	the Simulator of Human Intestinal Microbial Ecosystem (SHIME®)	387:448	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	1	43	dep	bifidobacteria	224:237	arg1	e.g.					218:221	e.g.	218:221	e.g.	218:221	: Background: Prebiotics used as a dietary supplement, stimulate health-related gut microbiota (e.g., bifidobacteria, lactobacilli, etc.).
32466615	4	44	theme	acids	720:724	arg1	levels					734:739	lactate, ammonium, and short-chain fatty acids (SCFAs) levels	679:739	lactate, ammonium, and short-chain fatty acids (SCFAs) levels	679:739	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	4	44	theme	acids	720:724	arg1	pH					661:662	pH	661:662	pH	661:662	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	11	45	theme	h.	1389:1390	arg1	CONCLUSION					1392:1401	48 h. CONCLUSION	1386:1401	48 h. CONCLUSION AADE	1386:1406	Lactate levels initially increased but branched SCFA and ammonium levels remained low till 48 h. CONCLUSION AADE displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE.
32466615	2	46	theme	dry	334:336	arg1	AADE					347:350	AADE	347:350	AADE	347:350	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	2	46	theme	dry	334:336	arg1	extract					338:344	an artichoke aqueous dry extract	313:344	an artichoke aqueous dry extract (AADE)	313:351	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	2	47	theme	Microbial	421:429	arg1	Ecosystem					431:439	Human Intestinal Microbial Ecosystem	404:439	Human Intestinal Microbial Ecosystem (SHIME®)	404:448	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	2	47	theme	Microbial	421:429	arg1	SHIME®					442:447	SHIME®	442:447	SHIME®	442:447	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	4	48	theme	fatty	714:718	arg1	SCFAs					727:731	SCFAs	727:731	SCFAs	727:731	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	4	48	theme	fatty	714:718	arg1	acids					720:724	short-chain fatty acids	702:724	short-chain fatty acids (SCFAs)	702:732	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	2	49	theme	aqueous	326:332	arg1	AADE					347:350	AADE	347:350	AADE	347:350	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	2	49	theme	aqueous	326:332	arg1	extract					338:344	an artichoke aqueous dry extract	313:344	an artichoke aqueous dry extract (AADE)	313:351	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	0	50	dep	In	0:1	arg1	Vitro					3:7	Vitro	3:7	Vitro	3:7	In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract Revealed Bifidogenic Effects.
32466615	11	51	from	inulin	1566:1571	arg1	AADE					1576:1579	AADE	1576:1579	AADE	1576:1579	Lactate levels initially increased but branched SCFA and ammonium levels remained low till 48 h. CONCLUSION AADE displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE.
32466615	2	52	dep	in	359:360	arg1	vitro					362:366	vitro	362:366	vitro	362:366	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	2	53	theme	artichoke	316:324	arg1	AADE					347:350	AADE	347:350	AADE	347:350	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	2	53	theme	artichoke	316:324	arg1	extract					338:344	an artichoke aqueous dry extract	313:344	an artichoke aqueous dry extract (AADE)	313:351	This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®).
32466615	4	54	theme	lactate	679:685	arg1	levels					734:739	lactate, ammonium, and short-chain fatty acids (SCFAs) levels	679:739	lactate, ammonium, and short-chain fatty acids (SCFAs) levels	679:739	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	4	54	theme	lactate	679:685	arg1	pH					661:662	pH	661:662	pH	661:662	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	4	55	theme	colonic	628:634	arg1	incubation					636:645	colonic incubation	628:645	colonic incubation	628:645	Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty acids (SCFAs) levels.
32466615	0	56	theme	Artichoke	60:68	arg1	Extract					84:90	a Commercial Artichoke Inflorescence Extract	47:90	a Commercial Artichoke Inflorescence Extract	47:90	In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract Revealed Bifidogenic Effects.
32466615	11	57	theme	Lactate	1295:1301	arg1	levels					1303:1308	Lactate levels	1295:1308	Lactate levels	1295:1308	Lactate levels initially increased but branched SCFA and ammonium levels remained low till 48 h. CONCLUSION AADE displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE.
32466615	3	58	theme	blank	545:549	arg1	METHODS					451:457	METHODS	451:457	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank	451:549	METHODS Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank were performed.
32466615	11	59	theme	prebiotic	1418:1426	arg1	potential					1428:1436	prebiotic potential	1418:1436	prebiotic potential	1418:1436	Lactate levels initially increased but branched SCFA and ammonium levels remained low till 48 h. CONCLUSION AADE displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE.
32466615	6	60	theme	p	923:923	arg1	FOS					918:920	FOS	918:920	FOS (p < 0.05)	918:931	RESULTS After 24 and 48 h of incubation, bifidobacteria levels increased 25-fold with AADE (p < 0.05) and >100-fold with FOS (p < 0.05) compared to blank.
32466615	6	60	theme	p	923:923	arg1	<					925:925	p < 0.05	923:930	p < 0.05	923:930	RESULTS After 24 and 48 h of incubation, bifidobacteria levels increased 25-fold with AADE (p < 0.05) and >100-fold with FOS (p < 0.05) compared to blank.
32466615	6	61	theme	p	889:889	arg1	AADE					883:886	AADE	883:886	AADE (p < 0.05)	883:897	RESULTS After 24 and 48 h of incubation, bifidobacteria levels increased 25-fold with AADE (p < 0.05) and >100-fold with FOS (p < 0.05) compared to blank.
32466615	6	61	theme	p	889:889	arg1	<					891:891	p < 0.05	889:896	p < 0.05	889:896	RESULTS After 24 and 48 h of incubation, bifidobacteria levels increased 25-fold with AADE (p < 0.05) and >100-fold with FOS (p < 0.05) compared to blank.
32466615	0	62	theme	Commercial	49:58	arg1	Extract					84:90	a Commercial Artichoke Inflorescence Extract	47:90	a Commercial Artichoke Inflorescence Extract	47:90	In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract Revealed Bifidogenic Effects.
32466615	1	63	dep	microbiota	206:215	arg1	etc					254:256	etc	254:256	etc	254:256	: Background: Prebiotics used as a dietary supplement, stimulate health-related gut microbiota (e.g., bifidobacteria, lactobacilli, etc.).
32466615	1	63	dep	microbiota	206:215	arg1	lactobacilli					240:251	lactobacilli	240:251	lactobacilli	240:251	: Background: Prebiotics used as a dietary supplement, stimulate health-related gut microbiota (e.g., bifidobacteria, lactobacilli, etc.).
32466615	1	63	dep	microbiota	206:215	arg1	bifidobacteria					224:237	bifidobacteria	224:237	bifidobacteria	224:237	: Background: Prebiotics used as a dietary supplement, stimulate health-related gut microbiota (e.g., bifidobacteria, lactobacilli, etc.).
32466615	11	64	theme	CONCLUSION	1392:1401	arg1	AADE					1403:1406	48 h. CONCLUSION AADE	1386:1406	48 h. CONCLUSION AADE	1386:1406	Lactate levels initially increased but branched SCFA and ammonium levels remained low till 48 h. CONCLUSION AADE displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE.
32466615	11	65	theme	health-related	1500:1513	arg1	metabolites					1525:1535	health-related microbial metabolites	1500:1535	health-related microbial metabolites	1500:1535	Lactate levels initially increased but branched SCFA and ammonium levels remained low till 48 h. CONCLUSION AADE displayed prebiotic potential by exerting bifidogenic effects that stimulated production of health-related microbial metabolites, which is potentially due to inulin in AADE.
32466615	9	66	theme	study	1187:1191	arg1	end					1180:1182	the end	1176:1182	the end of study	1176:1191	At 6 h, pH decreased with AADE and FOS and remained stable until 48 h; however, gas pressure increased significantly till the end of study.
32084475	0	0	theme	alcohol	83:89	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of green carboxymethylchitosan (CMCS) - Polyvinyl alcohol (PVA) electrospun nanofibers containing gold nanoparticles (AuNPs) and its potential use as biomaterials.
32084475	0	0	theme	alcohol	83:89	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of green carboxymethylchitosan (CMCS) - Polyvinyl alcohol (PVA) electrospun nanofibers containing gold nanoparticles (AuNPs) and its potential use as biomaterials.
32084475	0	1	theme	potential	166:174	arg1	use					176:178	its potential use	162:178	its potential use as biomaterials	162:194	Preparation and characterization of green carboxymethylchitosan (CMCS) - Polyvinyl alcohol (PVA) electrospun nanofibers containing gold nanoparticles (AuNPs) and its potential use as biomaterials.
32084475	0	2	theme	Polyvinyl	73:81	arg1	PVA					92:94	PVA	92:94	PVA	92:94	Preparation and characterization of green carboxymethylchitosan (CMCS) - Polyvinyl alcohol (PVA) electrospun nanofibers containing gold nanoparticles (AuNPs) and its potential use as biomaterials.
32084475	0	2	theme	Polyvinyl	73:81	arg1	alcohol					83:89	Polyvinyl alcohol	73:89	Polyvinyl alcohol (PVA)	73:95	Preparation and characterization of green carboxymethylchitosan (CMCS) - Polyvinyl alcohol (PVA) electrospun nanofibers containing gold nanoparticles (AuNPs) and its potential use as biomaterials.
32084475	4	3	theme	CMCS	682:685	arg1	nanofibers					687:696	CMCS nanofibers	682:696	CMCS nanofibers	682:696	The AuNPs has spherical shapes, its diameter ranged from 15 to 25 nm and uniform distributed within CMCS nanofibers.
32084475	7	4	theme	ultra-fine	935:944	arg1	fibers					946:951	ultra-fine fibers	935:951	ultra-fine fibers	935:951	Results showed that ultra-fine fibers were generated after addition of PVA to CMCS solution.
32084475	0	5	theme	electrospun	97:107	arg1	nanofibers					109:118	electrospun nanofibers	97:118	electrospun nanofibers	97:118	Preparation and characterization of green carboxymethylchitosan (CMCS) - Polyvinyl alcohol (PVA) electrospun nanofibers containing gold nanoparticles (AuNPs) and its potential use as biomaterials.
32084475	1	6	from	application	284:294	arg1	field					311:315	the medical field	299:315	the medical field	299:315	Green chemistry was used in nanostructures preparation to impart it amazing innovating application in the medical field.
32084475	3	7	contain	contains	422:429	arg2	carboxymethylchitosan					431:451	carboxymethylchitosan	431:451	carboxymethylchitosan (CMCS)	431:458	This nanocomposite contains carboxymethylchitosan (CMCS) as safe reducing agent for gold nanoparticles (AuNPs) and polyvinyl alcohol (PVA) as nanofiber aiding material formation.
32084475	3	7	contain	contains	422:429	arg1	nanocomposite					408:420	This nanocomposite	403:420	This nanocomposite	403:420	This nanocomposite contains carboxymethylchitosan (CMCS) as safe reducing agent for gold nanoparticles (AuNPs) and polyvinyl alcohol (PVA) as nanofiber aiding material formation.
32084475	3	7	contain	contains	422:429	arg2	CMCS					454:457	CMCS	454:457	CMCS	454:457	This nanocomposite contains carboxymethylchitosan (CMCS) as safe reducing agent for gold nanoparticles (AuNPs) and polyvinyl alcohol (PVA) as nanofiber aiding material formation.
32084475	5	8	theme	%	782:782	arg1	CMCS					784:787	2 wt% CMCS	778:787	2 wt% CMCS	778:787	The optimum conditions for electrospinning were 10 wt% total solution contains 2 wt% CMCS and 8 wt% PVA.
32084475	6	9	used	used	882:885	arg2	SEM					873:875	SEM	873:875	SEM	873:875	UV-vis, TEM and XRD were used to characterize AuNPs whereas FTIR and SEM were used to characterize nanofibers.
32084475	6	9	used	used	882:885	arg2	FTIR					864:867	FTIR	864:867	FTIR	864:867	UV-vis, TEM and XRD were used to characterize AuNPs whereas FTIR and SEM were used to characterize nanofibers.
32084475	5	10	theme	2 wt	778:781	arg1	CMCS					784:787	2 wt% CMCS	778:787	2 wt% CMCS	778:787	The optimum conditions for electrospinning were 10 wt% total solution contains 2 wt% CMCS and 8 wt% PVA.
32084475	9	11	theme	viability	1175:1183	arg1	assay					1185:1189	Cell viability assay	1170:1189	Cell viability assay	1170:1189	Finally, the cytotoxicity of CMCS has been evaluated through Cell viability assay, which confirm that the nanofiber composite is non-toxic and tissue compatible.
32084475	8	12	theme	antibacterial	1061:1073	arg1	activity					1075:1082	excellent antibacterial activity	1051:1082	excellent antibacterial activity towards tested bacteria	1051:1106	Also, CMCS nanofibers containing AuNPs has excellent antibacterial activity towards tested bacteria.
32084475	5	13	theme	8 wt	793:796	arg1	PVA					799:801	8 wt% PVA	793:801	8 wt% PVA	793:801	The optimum conditions for electrospinning were 10 wt% total solution contains 2 wt% CMCS and 8 wt% PVA.
32084475	8	14	theme	containing	1030:1039	arg1	AuNPs					1041:1045	CMCS nanofibers containing AuNPs	1014:1045	CMCS nanofibers containing AuNPs	1014:1045	Also, CMCS nanofibers containing AuNPs has excellent antibacterial activity towards tested bacteria.
32084475	3	15	theme	material	562:569	arg1	formation					571:579	material formation	562:579	material formation	562:579	This nanocomposite contains carboxymethylchitosan (CMCS) as safe reducing agent for gold nanoparticles (AuNPs) and polyvinyl alcohol (PVA) as nanofiber aiding material formation.
32084475	2	16	theme	antibacterial	374:386	arg1	nanocomposite					388:400	novel, cost effective and ultra-safe antibacterial nanocomposite	337:400	novel, cost effective and ultra-safe antibacterial nanocomposite	337:400	Herein we prepared novel, cost effective and ultra-safe antibacterial nanocomposite.
32084475	5	17	theme	%	797:797	arg1	PVA					799:801	8 wt% PVA	793:801	8 wt% PVA	793:801	The optimum conditions for electrospinning were 10 wt% total solution contains 2 wt% CMCS and 8 wt% PVA.
32084475	1	18	theme	amazing	265:271	arg1	application					284:294	amazing innovating application	265:294	it amazing innovating application in the medical field	262:315	Green chemistry was used in nanostructures preparation to impart it amazing innovating application in the medical field.
32084475	8	19	theme	nanofibers	1019:1028	arg1	AuNPs					1041:1045	CMCS nanofibers containing AuNPs	1014:1045	CMCS nanofibers containing AuNPs	1014:1045	Also, CMCS nanofibers containing AuNPs has excellent antibacterial activity towards tested bacteria.
32084475	8	20	theme	CMCS	1014:1017	arg1	AuNPs					1041:1045	CMCS nanofibers containing AuNPs	1014:1045	CMCS nanofibers containing AuNPs	1014:1045	Also, CMCS nanofibers containing AuNPs has excellent antibacterial activity towards tested bacteria.
32084475	2	21	theme	ultra-safe	363:372	arg1	nanocomposite					388:400	novel, cost effective and ultra-safe antibacterial nanocomposite	337:400	novel, cost effective and ultra-safe antibacterial nanocomposite	337:400	Herein we prepared novel, cost effective and ultra-safe antibacterial nanocomposite.
32084475	1	22	theme	innovating	273:282	arg1	application					284:294	amazing innovating application	265:294	it amazing innovating application in the medical field	262:315	Green chemistry was used in nanostructures preparation to impart it amazing innovating application in the medical field.
32084475	9	23	theme	Cell	1170:1173	arg1	assay					1185:1189	Cell viability assay	1170:1189	Cell viability assay	1170:1189	Finally, the cytotoxicity of CMCS has been evaluated through Cell viability assay, which confirm that the nanofiber composite is non-toxic and tissue compatible.
32084475	2	24	dep	novel	337:341	arg1	cost					344:347	cost	344:347	cost	344:347	Herein we prepared novel, cost effective and ultra-safe antibacterial nanocomposite.
32084475	8	25	contain	has	1047:1049	arg1	AuNPs					1041:1045	CMCS nanofibers containing AuNPs	1014:1045	CMCS nanofibers containing AuNPs	1014:1045	Also, CMCS nanofibers containing AuNPs has excellent antibacterial activity towards tested bacteria.
32084475	8	25	contain	has	1047:1049	arg2	activity					1075:1082	excellent antibacterial activity	1051:1082	excellent antibacterial activity towards tested bacteria	1051:1106	Also, CMCS nanofibers containing AuNPs has excellent antibacterial activity towards tested bacteria.
32084475	0	26	theme	carboxymethylchitosan	42:62	arg1	characterization					16:31	characterization	16:31	characterization	16:31	Preparation and characterization of green carboxymethylchitosan (CMCS) - Polyvinyl alcohol (PVA) electrospun nanofibers containing gold nanoparticles (AuNPs) and its potential use as biomaterials.
32084475	0	26	theme	carboxymethylchitosan	42:62	arg1	Preparation					0:10	Preparation	0:10	Preparation	0:10	Preparation and characterization of green carboxymethylchitosan (CMCS) - Polyvinyl alcohol (PVA) electrospun nanofibers containing gold nanoparticles (AuNPs) and its potential use as biomaterials.
32084475	5	27	theme	optimum	703:709	arg1	%					752:752	10 wt%	747:752	10 wt%	747:752	The optimum conditions for electrospinning were 10 wt% total solution contains 2 wt% CMCS and 8 wt% PVA.
32084475	5	27	theme	optimum	703:709	arg1	conditions					711:720	The optimum conditions	699:720	The optimum conditions for electrospinning	699:740	The optimum conditions for electrospinning were 10 wt% total solution contains 2 wt% CMCS and 8 wt% PVA.
32084475	3	28	theme	safe	463:466	arg1	agent					477:481	safe reducing agent	463:481	safe reducing agent for gold nanoparticles (AuNPs) and polyvinyl alcohol (PVA)	463:540	This nanocomposite contains carboxymethylchitosan (CMCS) as safe reducing agent for gold nanoparticles (AuNPs) and polyvinyl alcohol (PVA) as nanofiber aiding material formation.
32084475	1	29	theme	Green	197:201	arg1	chemistry					203:211	Green chemistry	197:211	Green chemistry	197:211	Green chemistry was used in nanostructures preparation to impart it amazing innovating application in the medical field.
32084475	0	30	theme	green	36:40	arg1	carboxymethylchitosan					42:62	green carboxymethylchitosan	36:62	green carboxymethylchitosan (CMCS)	36:69	Preparation and characterization of green carboxymethylchitosan (CMCS) - Polyvinyl alcohol (PVA) electrospun nanofibers containing gold nanoparticles (AuNPs) and its potential use as biomaterials.
32084475	0	30	theme	green	36:40	arg1	CMCS					65:68	CMCS	65:68	CMCS	65:68	Preparation and characterization of green carboxymethylchitosan (CMCS) - Polyvinyl alcohol (PVA) electrospun nanofibers containing gold nanoparticles (AuNPs) and its potential use as biomaterials.
32084475	0	31	theme	gold	131:134	arg1	AuNPs					151:155	AuNPs	151:155	AuNPs	151:155	Preparation and characterization of green carboxymethylchitosan (CMCS) - Polyvinyl alcohol (PVA) electrospun nanofibers containing gold nanoparticles (AuNPs) and its potential use as biomaterials.
32084475	0	31	theme	gold	131:134	arg1	nanoparticles					136:148	gold nanoparticles	131:148	gold nanoparticles (AuNPs)	131:156	Preparation and characterization of green carboxymethylchitosan (CMCS) - Polyvinyl alcohol (PVA) electrospun nanofibers containing gold nanoparticles (AuNPs) and its potential use as biomaterials.
32084475	4	32	contain	has	592:594	arg1	AuNPs					586:590	The AuNPs	582:590	The AuNPs	582:590	The AuNPs has spherical shapes, its diameter ranged from 15 to 25 nm and uniform distributed within CMCS nanofibers.
32084475	4	32	contain	has	592:594	arg2	diameter					618:625	its diameter	614:625	its diameter ranged from 15 to 25 nm and uniform distributed within CMCS nanofibers	614:696	The AuNPs has spherical shapes, its diameter ranged from 15 to 25 nm and uniform distributed within CMCS nanofibers.
32084475	4	32	contain	has	592:594	arg2	shapes					606:611	spherical shapes	596:611	spherical shapes	596:611	The AuNPs has spherical shapes, its diameter ranged from 15 to 25 nm and uniform distributed within CMCS nanofibers.
32084475	7	33	theme	PVA	986:988	arg1	addition					974:981	addition	974:981	addition of PVA to CMCS solution	974:1005	Results showed that ultra-fine fibers were generated after addition of PVA to CMCS solution.
32084475	3	34	theme	reducing	468:475	arg1	agent					477:481	safe reducing agent	463:481	safe reducing agent for gold nanoparticles (AuNPs) and polyvinyl alcohol (PVA)	463:540	This nanocomposite contains carboxymethylchitosan (CMCS) as safe reducing agent for gold nanoparticles (AuNPs) and polyvinyl alcohol (PVA) as nanofiber aiding material formation.
32084475	6	35	used	used	829:832	arg2	UV-vis					804:809	UV-vis	804:809	UV-vis	804:809	UV-vis, TEM and XRD were used to characterize AuNPs whereas FTIR and SEM were used to characterize nanofibers.
32084475	6	35	used	used	829:832	arg2	XRD					820:822	XRD	820:822	XRD	820:822	UV-vis, TEM and XRD were used to characterize AuNPs whereas FTIR and SEM were used to characterize nanofibers.
32084475	6	35	used	used	829:832	arg2	TEM					812:814	TEM	812:814	TEM	812:814	UV-vis, TEM and XRD were used to characterize AuNPs whereas FTIR and SEM were used to characterize nanofibers.
32084475	1	36	theme	medical	303:309	arg1	field					311:315	the medical field	299:315	the medical field	299:315	Green chemistry was used in nanostructures preparation to impart it amazing innovating application in the medical field.
32084475	9	37	theme	nanofiber	1215:1223	arg1	non-toxic					1238:1246	non-toxic	1238:1246	non-toxic	1238:1246	Finally, the cytotoxicity of CMCS has been evaluated through Cell viability assay, which confirm that the nanofiber composite is non-toxic and tissue compatible.
32084475	9	37	theme	nanofiber	1215:1223	arg1	composite					1225:1233	the nanofiber composite	1211:1233	the nanofiber composite	1211:1233	Finally, the cytotoxicity of CMCS has been evaluated through Cell viability assay, which confirm that the nanofiber composite is non-toxic and tissue compatible.
32084475	0	38	dep	carboxymethylchitosan	42:62	arg1	nanofibers					109:118	electrospun nanofibers	97:118	electrospun nanofibers	97:118	Preparation and characterization of green carboxymethylchitosan (CMCS) - Polyvinyl alcohol (PVA) electrospun nanofibers containing gold nanoparticles (AuNPs) and its potential use as biomaterials.
32084475	2	39	theme	novel	337:341	arg1	nanocomposite					388:400	novel, cost effective and ultra-safe antibacterial nanocomposite	337:400	novel, cost effective and ultra-safe antibacterial nanocomposite	337:400	Herein we prepared novel, cost effective and ultra-safe antibacterial nanocomposite.
32084475	8	40	theme	excellent	1051:1059	arg1	activity					1075:1082	excellent antibacterial activity	1051:1082	excellent antibacterial activity towards tested bacteria	1051:1106	Also, CMCS nanofibers containing AuNPs has excellent antibacterial activity towards tested bacteria.
32084475	7	41	theme	CMCS	993:996	arg1	solution					998:1005	CMCS solution	993:1005	CMCS solution	993:1005	Results showed that ultra-fine fibers were generated after addition of PVA to CMCS solution.
32084475	1	42	dep	it	262:263	arg1	application					284:294	amazing innovating application	265:294	it amazing innovating application in the medical field	262:315	Green chemistry was used in nanostructures preparation to impart it amazing innovating application in the medical field.
32084475	3	43	theme	gold	487:490	arg1	AuNPs					507:511	AuNPs	507:511	AuNPs	507:511	This nanocomposite contains carboxymethylchitosan (CMCS) as safe reducing agent for gold nanoparticles (AuNPs) and polyvinyl alcohol (PVA) as nanofiber aiding material formation.
32084475	3	43	theme	gold	487:490	arg1	nanoparticles					492:504	gold nanoparticles	487:504	gold nanoparticles (AuNPs)	487:512	This nanocomposite contains carboxymethylchitosan (CMCS) as safe reducing agent for gold nanoparticles (AuNPs) and polyvinyl alcohol (PVA) as nanofiber aiding material formation.
32084475	8	44	theme	tested	1092:1097	arg1	bacteria					1099:1106	tested bacteria	1092:1106	tested bacteria	1092:1106	Also, CMCS nanofibers containing AuNPs has excellent antibacterial activity towards tested bacteria.
32084475	1	45	used	used	217:220	arg2	chemistry					203:211	Green chemistry	197:211	Green chemistry	197:211	Green chemistry was used in nanostructures preparation to impart it amazing innovating application in the medical field.
32084475	4	46	theme	spherical	596:604	arg1	shapes					606:611	spherical shapes	596:611	spherical shapes	596:611	The AuNPs has spherical shapes, its diameter ranged from 15 to 25 nm and uniform distributed within CMCS nanofibers.
32084475	4	46	theme	spherical	596:604	arg1	diameter					618:625	its diameter	614:625	its diameter ranged from 15 to 25 nm and uniform distributed within CMCS nanofibers	614:696	The AuNPs has spherical shapes, its diameter ranged from 15 to 25 nm and uniform distributed within CMCS nanofibers.
32084475	4	47	dep	25 nm	645:649	arg1	to					642:643	to	642:643	to	642:643	The AuNPs has spherical shapes, its diameter ranged from 15 to 25 nm and uniform distributed within CMCS nanofibers.
32084475	3	48	theme	polyvinyl	518:526	arg1	PVA					537:539	PVA	537:539	PVA	537:539	This nanocomposite contains carboxymethylchitosan (CMCS) as safe reducing agent for gold nanoparticles (AuNPs) and polyvinyl alcohol (PVA) as nanofiber aiding material formation.
32084475	3	48	theme	polyvinyl	518:526	arg1	alcohol					528:534	polyvinyl alcohol	518:534	polyvinyl alcohol (PVA)	518:540	This nanocomposite contains carboxymethylchitosan (CMCS) as safe reducing agent for gold nanoparticles (AuNPs) and polyvinyl alcohol (PVA) as nanofiber aiding material formation.
32084475	5	49	theme	total	754:758	arg1	solution					760:767	total solution	754:767	total solution	754:767	The optimum conditions for electrospinning were 10 wt% total solution contains 2 wt% CMCS and 8 wt% PVA.
32084475	5	50	contain	contains	769:776	arg2	PVA					799:801	8 wt% PVA	793:801	8 wt% PVA	793:801	The optimum conditions for electrospinning were 10 wt% total solution contains 2 wt% CMCS and 8 wt% PVA.
32084475	5	50	contain	contains	769:776	arg1	solution					760:767	total solution	754:767	total solution	754:767	The optimum conditions for electrospinning were 10 wt% total solution contains 2 wt% CMCS and 8 wt% PVA.
32084475	5	50	contain	contains	769:776	arg2	CMCS					784:787	2 wt% CMCS	778:787	2 wt% CMCS	778:787	The optimum conditions for electrospinning were 10 wt% total solution contains 2 wt% CMCS and 8 wt% PVA.
32084475	9	51	theme	CMCS	1138:1141	arg1	cytotoxicity					1122:1133	the cytotoxicity	1118:1133	the cytotoxicity of CMCS	1118:1141	Finally, the cytotoxicity of CMCS has been evaluated through Cell viability assay, which confirm that the nanofiber composite is non-toxic and tissue compatible.
32084475	2	52	theme	effective	349:357	arg1	nanocomposite					388:400	novel, cost effective and ultra-safe antibacterial nanocomposite	337:400	novel, cost effective and ultra-safe antibacterial nanocomposite	337:400	Herein we prepared novel, cost effective and ultra-safe antibacterial nanocomposite.
32084475	1	53	theme	nanostructures	225:238	arg1	preparation					240:250	nanostructures preparation	225:250	nanostructures preparation	225:250	Green chemistry was used in nanostructures preparation to impart it amazing innovating application in the medical field.
32959451	4	0	theme	X-ray	874:878	arg1	scattering					880:889	in situ small-angle X-ray scattering	854:889	in situ small-angle X-ray scattering	854:889	The polyrotaxane crosslinks are movable under external force as disclosed by in situ small-angle X-ray scattering and other techniques, which is correlated to the relative amount of α-CDs.
32959451	1	1	theme	moveable	162:169	arg1	polyrotaxane					199:210	moveable α-cyclodextrin (α-CD) based polyrotaxane	162:210	moveable α-cyclodextrin (α-CD) based polyrotaxane	162:210	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane favors toughening of hydrogels, but the strategy is rarely applied in bulk polymers because of the severe aggregation trend of α-CDs.
32959451	1	2	theme	α-CDs	339:343	arg1	trend					330:334	the severe aggregation trend	307:334	the severe aggregation trend of α-CDs	307:343	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane favors toughening of hydrogels, but the strategy is rarely applied in bulk polymers because of the severe aggregation trend of α-CDs.
32959451	2	3	theme	polyrotaxane	593:604	arg1	hydrophilicity					575:588	hydrophilicity	575:588	hydrophilicity	575:588	Herein, the authors propose a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane.
32959451	2	3	theme	polyrotaxane	593:604	arg1	α-CDs					565:569	α-CDs	565:569	α-CDs	565:569	Herein, the authors propose a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane.
32959451	1	4	theme	α-cyclodextrin	171:184	arg1	polyrotaxane					199:210	moveable α-cyclodextrin (α-CD) based polyrotaxane	162:210	moveable α-cyclodextrin (α-CD) based polyrotaxane	162:210	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane favors toughening of hydrogels, but the strategy is rarely applied in bulk polymers because of the severe aggregation trend of α-CDs.
32959451	0	5	from	Implementation	0:13	arg1	Polymer					72:78	Transparent Bulk Polymer	55:78	Transparent Bulk Polymer	55:78	Implementation of the Pulley Effect of Polyrotaxane in Transparent Bulk Polymer for Simultaneous Strengthening and Toughening.
32959451	6	6	theme	expandable	1158:1167	arg1	toolbox					1169:1175	an expandable toolbox	1155:1175	an expandable toolbox for enhancing polymers	1155:1198	The present work provides an expandable toolbox for enhancing polymers.
32959451	6	7	theme	enhancing	1181:1189	arg1	polymers					1191:1198	enhancing polymers	1181:1198	enhancing polymers	1181:1198	The present work provides an expandable toolbox for enhancing polymers.
32959451	0	8	theme	Simultaneous	84:95	arg1	Strengthening					97:109	Simultaneous Strengthening	84:109	Simultaneous Strengthening	84:109	Implementation of the Pulley Effect of Polyrotaxane in Transparent Bulk Polymer for Simultaneous Strengthening and Toughening.
32959451	2	9	theme	hydrophilicity	575:588	arg1	aggregation					550:560	the unwanted hydrogen bonds-induced aggregation	514:560	the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane	514:604	Herein, the authors propose a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane.
32959451	4	10	theme	α-CDs	959:963	arg1	α-CDs					959:963	α-CDs	959:963	α-CDs	959:963	The polyrotaxane crosslinks are movable under external force as disclosed by in situ small-angle X-ray scattering and other techniques, which is correlated to the relative amount of α-CDs.
32959451	4	10	theme	α-CDs	959:963	arg1	amount					949:954	the relative amount	936:954	the relative amount of α-CDs	936:963	The polyrotaxane crosslinks are movable under external force as disclosed by in situ small-angle X-ray scattering and other techniques, which is correlated to the relative amount of α-CDs.
32959451	5	11	theme	few	968:970	arg1	crosslinkers					985:996	A few polyrotaxane crosslinkers	966:996	A few polyrotaxane crosslinkers	966:996	A few polyrotaxane crosslinkers prove to be sufficient to simultaneously improve strength and toughness of poly(methyl acrylate) owing to the stress equalization.
32959451	5	11	theme	few	968:970	arg1	sufficient					1010:1019	sufficient	1010:1019	sufficient	1010:1019	A few polyrotaxane crosslinkers prove to be sufficient to simultaneously improve strength and toughness of poly(methyl acrylate) owing to the stress equalization.
32959451	4	12	theme	polyrotaxane	781:792	arg1	movable					809:815	movable	809:815	movable	809:815	The polyrotaxane crosslinks are movable under external force as disclosed by in situ small-angle X-ray scattering and other techniques, which is correlated to the relative amount of α-CDs.
32959451	4	12	theme	polyrotaxane	781:792	arg1	crosslinks					794:803	The polyrotaxane crosslinks	777:803	The polyrotaxane crosslinks	777:803	The polyrotaxane crosslinks are movable under external force as disclosed by in situ small-angle X-ray scattering and other techniques, which is correlated to the relative amount of α-CDs.
32959451	5	13	theme	stress	1108:1113	arg1	equalization					1115:1126	the stress equalization	1104:1126	the stress equalization	1104:1126	A few polyrotaxane crosslinkers prove to be sufficient to simultaneously improve strength and toughness of poly(methyl acrylate) owing to the stress equalization.
32959451	4	14	dep	in	854:855	arg1	situ					857:860	situ	857:860	situ	857:860	The polyrotaxane crosslinks are movable under external force as disclosed by in situ small-angle X-ray scattering and other techniques, which is correlated to the relative amount of α-CDs.
32959451	1	15	theme	α-CD	187:190	arg1	polyrotaxane					199:210	moveable α-cyclodextrin (α-CD) based polyrotaxane	162:210	moveable α-cyclodextrin (α-CD) based polyrotaxane	162:210	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane favors toughening of hydrogels, but the strategy is rarely applied in bulk polymers because of the severe aggregation trend of α-CDs.
32959451	5	16	theme	methyl	1078:1083	arg1	poly					1073:1076	poly	1073:1076	poly(methyl acrylate) owing to the stress equalization	1073:1126	A few polyrotaxane crosslinkers prove to be sufficient to simultaneously improve strength and toughness of poly(methyl acrylate) owing to the stress equalization.
32959451	5	16	theme	methyl	1078:1083	arg1	acrylate					1085:1092	methyl acrylate	1078:1092	methyl acrylate	1078:1092	A few polyrotaxane crosslinkers prove to be sufficient to simultaneously improve strength and toughness of poly(methyl acrylate) owing to the stress equalization.
32959451	0	17	from	Effect	29:34	arg1	Polymer					72:78	Transparent Bulk Polymer	55:78	Transparent Bulk Polymer	55:78	Implementation of the Pulley Effect of Polyrotaxane in Transparent Bulk Polymer for Simultaneous Strengthening and Toughening.
32959451	4	18	theme	other	895:899	arg1	techniques					901:910	other techniques	895:910	other techniques	895:910	The polyrotaxane crosslinks are movable under external force as disclosed by in situ small-angle X-ray scattering and other techniques, which is correlated to the relative amount of α-CDs.
32959451	2	19	theme	polyrotaxane	426:437	arg1	α-CDs					417:421	the α-CDs	413:421	the α-CDs of polyrotaxane	413:437	Herein, the authors propose a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane.
32959451	4	20	theme	in	854:855	arg1	scattering					880:889	in situ small-angle X-ray scattering	854:889	in situ small-angle X-ray scattering	854:889	The polyrotaxane crosslinks are movable under external force as disclosed by in situ small-angle X-ray scattering and other techniques, which is correlated to the relative amount of α-CDs.
32959451	3	21	with	homogeneous	738:748	arg1	transparency					763:774	optical transparency	755:774	optical transparency	755:774	Accordingly, the proof-of-concept material, poly(methyl acrylate) crosslinked by the modified polyrotaxane, turns out to be rather homogeneous with optical transparency.
32959451	1	22	theme	based	193:197	arg1	polyrotaxane					199:210	moveable α-cyclodextrin (α-CD) based polyrotaxane	162:210	moveable α-cyclodextrin (α-CD) based polyrotaxane	162:210	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane favors toughening of hydrogels, but the strategy is rarely applied in bulk polymers because of the severe aggregation trend of α-CDs.
32959451	0	23	theme	Pulley	22:27	arg1	Effect					29:34	the Pulley Effect	18:34	the Pulley Effect of Polyrotaxane in Transparent Bulk Polymer	18:78	Implementation of the Pulley Effect of Polyrotaxane in Transparent Bulk Polymer for Simultaneous Strengthening and Toughening.
32959451	1	24	theme	bulk	282:285	arg1	polymers					287:294	bulk polymers	282:294	bulk polymers because of the severe aggregation trend of α-CDs	282:343	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane favors toughening of hydrogels, but the strategy is rarely applied in bulk polymers because of the severe aggregation trend of α-CDs.
32959451	2	25	theme	bonds-induced	536:548	arg1	aggregation					550:560	the unwanted hydrogen bonds-induced aggregation	514:560	the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane	514:604	Herein, the authors propose a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane.
32959451	4	26	theme	small-angle	862:872	arg1	scattering					880:889	in situ small-angle X-ray scattering	854:889	in situ small-angle X-ray scattering	854:889	The polyrotaxane crosslinks are movable under external force as disclosed by in situ small-angle X-ray scattering and other techniques, which is correlated to the relative amount of α-CDs.
32959451	2	27	theme	hydrogen	527:534	arg1	aggregation					550:560	the unwanted hydrogen bonds-induced aggregation	514:560	the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane	514:604	Herein, the authors propose a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane.
32959451	5	28	theme	poly	1073:1076	arg1	toughness					1060:1068	toughness	1060:1068	toughness	1060:1068	A few polyrotaxane crosslinkers prove to be sufficient to simultaneously improve strength and toughness of poly(methyl acrylate) owing to the stress equalization.
32959451	5	28	theme	poly	1073:1076	arg1	strength					1047:1054	strength	1047:1054	strength	1047:1054	A few polyrotaxane crosslinkers prove to be sufficient to simultaneously improve strength and toughness of poly(methyl acrylate) owing to the stress equalization.
32959451	6	29	theme	present	1133:1139	arg1	work					1141:1144	The present work	1129:1144	The present work	1129:1144	The present work provides an expandable toolbox for enhancing polymers.
32959451	2	30	theme	side	467:470	arg1	groups					472:477	large steric side groups	454:477	large steric side groups	454:477	Herein, the authors propose a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane.
32959451	2	31	theme	unwanted	518:525	arg1	aggregation					550:560	the unwanted hydrogen bonds-induced aggregation	514:560	the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane	514:604	Herein, the authors propose a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane.
32959451	0	32	from	Polymer	72:78	arg1	Implementation					0:13	Implementation	0:13	Implementation of the Pulley Effect of Polyrotaxane in Transparent Bulk Polymer for Simultaneous Strengthening and Toughening.	0:125	Implementation of the Pulley Effect of Polyrotaxane in Transparent Bulk Polymer for Simultaneous Strengthening and Toughening.
32959451	4	33	theme	external	823:830	arg1	force					832:836	external force	823:836	external force	823:836	The polyrotaxane crosslinks are movable under external force as disclosed by in situ small-angle X-ray scattering and other techniques, which is correlated to the relative amount of α-CDs.
32959451	0	34	theme	Effect	29:34	arg1	Implementation					0:13	Implementation	0:13	Implementation of the Pulley Effect of Polyrotaxane in Transparent Bulk Polymer for Simultaneous Strengthening and Toughening.	0:125	Implementation of the Pulley Effect of Polyrotaxane in Transparent Bulk Polymer for Simultaneous Strengthening and Toughening.
32959451	2	35	theme	steric	460:465	arg1	groups					472:477	large steric side groups	454:477	large steric side groups	454:477	Herein, the authors propose a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane.
32959451	3	36	theme	optical	755:761	arg1	transparency					763:774	optical transparency	755:774	optical transparency	755:774	Accordingly, the proof-of-concept material, poly(methyl acrylate) crosslinked by the modified polyrotaxane, turns out to be rather homogeneous with optical transparency.
32959451	2	37	theme	large	454:458	arg1	groups					472:477	large steric side groups	454:477	large steric side groups	454:477	Herein, the authors propose a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane.
32959451	2	38	theme	reactive	483:490	arg1	CC					492:494	reactive CC	483:494	reactive CC	483:494	Herein, the authors propose a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane.
32959451	0	39	theme	Polyrotaxane	39:50	arg1	Effect					29:34	the Pulley Effect	18:34	the Pulley Effect of Polyrotaxane in Transparent Bulk Polymer	18:78	Implementation of the Pulley Effect of Polyrotaxane in Transparent Bulk Polymer for Simultaneous Strengthening and Toughening.
32959451	1	40	theme	severe	311:316	arg1	trend					330:334	the severe aggregation trend	307:334	the severe aggregation trend of α-CDs	307:343	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane favors toughening of hydrogels, but the strategy is rarely applied in bulk polymers because of the severe aggregation trend of α-CDs.
32959451	2	41	theme	α-CDs	565:569	arg1	aggregation					550:560	the unwanted hydrogen bonds-induced aggregation	514:560	the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane	514:604	Herein, the authors propose a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane.
32959451	1	42	from	polyrotaxane	199:210	arg1	effect					150:155	The fascinating pulley effect	127:155	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane	127:210	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane favors toughening of hydrogels, but the strategy is rarely applied in bulk polymers because of the severe aggregation trend of α-CDs.
32959451	3	43	theme	modified	692:699	arg1	polyrotaxane					701:712	the modified polyrotaxane	688:712	the modified polyrotaxane	688:712	Accordingly, the proof-of-concept material, poly(methyl acrylate) crosslinked by the modified polyrotaxane, turns out to be rather homogeneous with optical transparency.
32959451	1	44	theme	aggregation	318:328	arg1	trend					330:334	the severe aggregation trend	307:334	the severe aggregation trend of α-CDs	307:343	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane favors toughening of hydrogels, but the strategy is rarely applied in bulk polymers because of the severe aggregation trend of α-CDs.
32959451	1	45	theme	fascinating	131:141	arg1	effect					150:155	The fascinating pulley effect	127:155	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane	127:210	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane favors toughening of hydrogels, but the strategy is rarely applied in bulk polymers because of the severe aggregation trend of α-CDs.
32959451	1	46	theme	hydrogels	233:241	arg1	toughening					219:228	toughening	219:228	toughening of hydrogels	219:241	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane favors toughening of hydrogels, but the strategy is rarely applied in bulk polymers because of the severe aggregation trend of α-CDs.
32959451	5	47	theme	polyrotaxane	972:983	arg1	crosslinkers					985:996	A few polyrotaxane crosslinkers	966:996	A few polyrotaxane crosslinkers	966:996	A few polyrotaxane crosslinkers prove to be sufficient to simultaneously improve strength and toughness of poly(methyl acrylate) owing to the stress equalization.
32959451	5	47	theme	polyrotaxane	972:983	arg1	sufficient					1010:1019	sufficient	1010:1019	sufficient	1010:1019	A few polyrotaxane crosslinkers prove to be sufficient to simultaneously improve strength and toughness of poly(methyl acrylate) owing to the stress equalization.
32959451	3	48	theme	methyl	656:661	arg1	poly					651:654	poly	651:654	poly(methyl acrylate) crosslinked by the modified polyrotaxane	651:712	Accordingly, the proof-of-concept material, poly(methyl acrylate) crosslinked by the modified polyrotaxane, turns out to be rather homogeneous with optical transparency.
32959451	3	48	theme	methyl	656:661	arg1	acrylate					663:670	methyl acrylate	656:670	methyl acrylate	656:670	Accordingly, the proof-of-concept material, poly(methyl acrylate) crosslinked by the modified polyrotaxane, turns out to be rather homogeneous with optical transparency.
32959451	3	49	theme	proof-of-concept	624:639	arg1	poly					651:654	poly	651:654	poly(methyl acrylate) crosslinked by the modified polyrotaxane	651:712	Accordingly, the proof-of-concept material, poly(methyl acrylate) crosslinked by the modified polyrotaxane, turns out to be rather homogeneous with optical transparency.
32959451	3	49	theme	proof-of-concept	624:639	arg1	homogeneous					738:748	homogeneous	738:748	homogeneous	738:748	Accordingly, the proof-of-concept material, poly(methyl acrylate) crosslinked by the modified polyrotaxane, turns out to be rather homogeneous with optical transparency.
32959451	3	49	theme	proof-of-concept	624:639	arg1	material					641:648	the proof-of-concept material	620:648	the proof-of-concept material	620:648	Accordingly, the proof-of-concept material, poly(methyl acrylate) crosslinked by the modified polyrotaxane, turns out to be rather homogeneous with optical transparency.
32959451	1	50	theme	pulley	143:148	arg1	effect					150:155	The fascinating pulley effect	127:155	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane	127:210	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane favors toughening of hydrogels, but the strategy is rarely applied in bulk polymers because of the severe aggregation trend of α-CDs.
32959451	0	51	theme	Bulk	67:70	arg1	Polymer					72:78	Transparent Bulk Polymer	55:78	Transparent Bulk Polymer	55:78	Implementation of the Pulley Effect of Polyrotaxane in Transparent Bulk Polymer for Simultaneous Strengthening and Toughening.
32959451	2	52	theme	simple	376:381	arg1	approach					383:390	a simple approach	374:390	a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane	374:604	Herein, the authors propose a simple approach to moderately modify the α-CDs of polyrotaxane by introducing large steric side groups and reactive CC so as to minimize the unwanted hydrogen bonds-induced aggregation of α-CDs and hydrophilicity of polyrotaxane.
32959451	0	53	theme	Transparent	55:65	arg1	Polymer					72:78	Transparent Bulk Polymer	55:78	Transparent Bulk Polymer	55:78	Implementation of the Pulley Effect of Polyrotaxane in Transparent Bulk Polymer for Simultaneous Strengthening and Toughening.
32959451	1	54	theme	trend	330:334	arg1	polymers					287:294	bulk polymers	282:294	bulk polymers because of the severe aggregation trend of α-CDs	282:343	The fascinating pulley effect from moveable α-cyclodextrin (α-CD) based polyrotaxane favors toughening of hydrogels, but the strategy is rarely applied in bulk polymers because of the severe aggregation trend of α-CDs.
32959451	4	55	theme	relative	940:947	arg1	α-CDs					959:963	α-CDs	959:963	α-CDs	959:963	The polyrotaxane crosslinks are movable under external force as disclosed by in situ small-angle X-ray scattering and other techniques, which is correlated to the relative amount of α-CDs.
32959451	4	55	theme	relative	940:947	arg1	amount					949:954	the relative amount	936:954	the relative amount of α-CDs	936:963	The polyrotaxane crosslinks are movable under external force as disclosed by in situ small-angle X-ray scattering and other techniques, which is correlated to the relative amount of α-CDs.
32622307	9	0	theme	air	1569:1571	arg1	HCHO					1593:1596	HCHO	1593:1596	HCHO	1593:1596	This paper also had good physical properties and has the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO.
32622307	9	0	theme	air	1569:1571	arg1	pollutants					1573:1582	indoor air pollutants	1562:1582	indoor air pollutants	1562:1582	This paper also had good physical properties and has the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO.
32622307	6	1	theme	solid	1061:1065	arg1	solution					1047:1054	an ethanol spinning solution	1027:1054	an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4)	1027:1112	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	6	1	theme	solid	1061:1065	arg1	%					1059:1059	12% solid	1057:1065	12% solid	1057:1065	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	2	2	theme	3·5H2O	355:360	arg1	solution					371:378	Bi(NO3)3·5H2O glycerin solution	348:378	Bi(NO3)3·5H2O glycerin solution	348:378	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	3	3	theme	@	529:529	arg1	CPs					540:542	BiVO4@diatomite CPs	524:542	BiVO4@diatomite CPs	524:542	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	4	4	theme	pulp	685:688	arg1	fibers					690:695	pulp fibers	685:695	pulp fibers	685:695	BiVO4@diatomite/MCC/PVBCFs were then mixed with pulp fibers to prepare the visible light-responsive photocatalytic paper.
32622307	9	5	contain	has	1495:1497	arg1	paper					1451:1455	This paper	1446:1455	This paper	1446:1455	This paper also had good physical properties and has the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO.
32622307	9	5	contain	has	1495:1497	arg2	potential					1503:1511	the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO	1499:1596	the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO	1499:1596	This paper also had good physical properties and has the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO.
32622307	1	6	theme	degrading	207:215	arg1	pollutants					225:234	degrading organic pollutants	207:234	degrading organic pollutants	207:234	Combining adsorption and photocatalysis is an effective strategy for degrading organic pollutants.
32622307	7	7	contain	had	1136:1138	arg1	fibers					1129:1134	The resulting fibers	1115:1134	The resulting fibers	1115:1134	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	7	7	contain	had	1136:1138	arg2	structures					1165:1174	compact structures	1157:1174	compact structures	1157:1174	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	7	7	contain	had	1136:1138	arg2	surfaces					1147:1154	smooth surfaces	1140:1154	smooth surfaces	1140:1154	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	3	8	theme	ethanol	586:592	arg1	solution					594:601	PVB ethanol solution	582:601	PVB ethanol solution	582:601	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	5	9	theme	methylene	910:918	arg1	degradation					895:905	64.32% degradation	888:905	64.32% degradation of methylene blue (MB) after 4 h	888:938	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	3	10	theme	diatomite	530:538	arg1	CPs					540:542	BiVO4@diatomite CPs	524:542	BiVO4@diatomite CPs	524:542	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	8	11	theme	good	1374:1377	arg1	activity					1394:1401	good photocatalytic activity	1374:1401	good photocatalytic activity	1374:1401	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	5	12	with	CP	775:776	arg1	ratio					801:805	a BiVO4/diatomite ratio	783:805	a BiVO4/diatomite ratio of 6:4	783:812	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	3	13	theme	composite	459:467	arg1	fibers					469:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers	412:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs)	412:503	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	3	13	theme	composite	459:467	arg1	diatomite/MCC/PVBCFs					483:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	5	14	theme	BiVO4	759:763	arg1	CP					775:776	BiVO4@diatomite CP	759:776	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4	759:812	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	2	15	theme	composite	259:267	arg1	CP					300:301	BiVO4@diatomite CP	284:301	BiVO4@diatomite CP	284:301	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	2	15	theme	composite	259:267	arg1	photocatalyst					269:281	BiVO4@diatomite composite photocatalyst	243:281	BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP)	243:302	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	5	16	theme	64.32	888:892	arg1	%					893:893	%	893:893	%	893:893	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	2	17	theme	@	248:248	arg1	CP					300:301	BiVO4@diatomite CP	284:301	BiVO4@diatomite CP	284:301	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	2	17	theme	@	248:248	arg1	photocatalyst					269:281	BiVO4@diatomite composite photocatalyst	243:281	BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP)	243:302	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	6	18	theme	PVB	943:945	arg1	solution					955:962	A PVB ethanol solution	941:962	A PVB ethanol solution (6%)	941:967	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	6	18	theme	PVB	943:945	arg1	%					966:966	6%	965:966	6%	965:966	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	8	19	theme	50.20	1408:1412	arg1	%					1413:1413	%	1413:1413	%	1413:1413	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	2	20	theme	@	289:289	arg1	CP					300:301	BiVO4@diatomite CP	284:301	BiVO4@diatomite CP	284:301	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	2	20	theme	@	289:289	arg1	photocatalyst					269:281	BiVO4@diatomite composite photocatalyst	243:281	BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP)	243:302	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	7	21	theme	MB	1253:1254	arg1	degradation					1238:1248	degradation	1238:1248	degradation of MB and formaldehyde	1238:1271	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	5	22	theme	BiVO4/diatomite	785:799	arg1	ratio					801:805	a BiVO4/diatomite ratio	783:805	a BiVO4/diatomite ratio of 6:4	783:812	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	5	23	theme	good	854:857	arg1	activity					874:881	good photocatalytic activity	854:881	good photocatalytic activity	854:881	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	6	24	theme	diatomite	995:1003	arg1	CP					1005:1006	BiVO4@diatomite CP	989:1006	BiVO4@diatomite CP	989:1006	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	8	25	theme	HCHO	1430:1433	arg1	degradation					1415:1425	50.20% degradation	1408:1425	50.20% degradation of HCHO	1408:1433	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	4	26	theme	light-responsive	720:735	arg1	paper					752:756	the visible light-responsive photocatalytic paper	708:756	the visible light-responsive photocatalytic paper	708:756	BiVO4@diatomite/MCC/PVBCFs were then mixed with pulp fibers to prepare the visible light-responsive photocatalytic paper.
32622307	6	27	theme	BiVO4	989:993	arg1	CP					1005:1006	BiVO4@diatomite CP	989:1006	BiVO4@diatomite CP	989:1006	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	5	28	theme	diatomite	765:773	arg1	CP					775:776	BiVO4@diatomite CP	759:776	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4	759:812	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	9	29	theme	physical	1471:1478	arg1	properties					1480:1489	good physical properties	1466:1489	good physical properties	1466:1489	This paper also had good physical properties and has the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO.
32622307	0	30	theme	pollutants	126:135	arg1	degradation					103:113	degradation	103:113	degradation of organic pollutants	103:135	Preparation of visible light-responsive photocatalytic paper containing BiVO4@diatomite/MCC/PVBCFs for degradation of organic pollutants.
32622307	0	31	theme	paper	55:59	arg1	Preparation					0:10	Preparation	0:10	Preparation of visible light-responsive photocatalytic paper	0:59	Preparation of visible light-responsive photocatalytic paper containing BiVO4@diatomite/MCC/PVBCFs for degradation of organic pollutants.
32622307	3	32	theme	cellulose/PVB	445:457	arg1	fibers					469:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers	412:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs)	412:503	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	3	32	theme	cellulose/PVB	445:457	arg1	diatomite/MCC/PVBCFs					483:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	6	33	theme	spinning	1038:1045	arg1	solution					1047:1054	an ethanol spinning solution	1027:1054	an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4)	1027:1112	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	6	33	theme	spinning	1038:1045	arg1	%					1059:1059	12% solid	1057:1065	12% solid	1057:1065	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	8	34	theme	Photocatalytic	1307:1320	arg1	paper					1322:1326	Photocatalytic paper	1307:1326	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs	1307:1368	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	0	35	theme	visible	15:21	arg1	paper					55:59	visible light-responsive photocatalytic paper	15:59	visible light-responsive photocatalytic paper	15:59	Preparation of visible light-responsive photocatalytic paper containing BiVO4@diatomite/MCC/PVBCFs for degradation of organic pollutants.
32622307	3	36	theme	@	417:417	arg1	fibers					469:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers	412:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs)	412:503	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	3	36	theme	@	417:417	arg1	diatomite/MCC/PVBCFs					483:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	0	37	theme	@	77:77	arg1	diatomite/MCC/PVBCFs					78:97	BiVO4@diatomite/MCC/PVBCFs	72:97	BiVO4@diatomite/MCC/PVBCFs for degradation of organic pollutants	72:135	Preparation of visible light-responsive photocatalytic paper containing BiVO4@diatomite/MCC/PVBCFs for degradation of organic pollutants.
32622307	7	38	dep	exhibited	1180:1188	arg1	HCHO					1274:1277	HCHO	1274:1277	HCHO	1274:1277	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	7	38	dep	exhibited	1180:1188	arg1	%					1225:1225	66.80%	1220:1225	66.80%	1220:1225	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	7	38	dep	exhibited	1180:1188	arg1	%					1236:1236	56.80%	1231:1236	56.80%	1231:1236	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	3	39	theme	BiVO4	477:481	arg1	fibers					469:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers	412:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs)	412:503	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	3	39	theme	BiVO4	477:481	arg1	diatomite/MCC/PVBCFs					483:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	0	40	theme	photocatalytic	40:53	arg1	paper					55:59	visible light-responsive photocatalytic paper	15:59	visible light-responsive photocatalytic paper	15:59	Preparation of visible light-responsive photocatalytic paper containing BiVO4@diatomite/MCC/PVBCFs for degradation of organic pollutants.
32622307	9	41	contain	had	1462:1464	arg1	paper					1451:1455	This paper	1446:1455	This paper	1446:1455	This paper also had good physical properties and has the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO.
32622307	9	41	contain	had	1462:1464	arg2	properties					1480:1489	good physical properties	1466:1489	good physical properties	1466:1489	This paper also had good physical properties and has the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO.
32622307	7	42	theme	good	1190:1193	arg1	activity					1210:1217	good photocatalytic activity	1190:1217	good photocatalytic activity	1190:1217	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	8	43	theme	%	1341:1341	arg1	diatomite/MCC/PVBCFs					1349:1368	18% BiVO4@diatomite/MCC/PVBCFs	1339:1368	18% BiVO4@diatomite/MCC/PVBCFs	1339:1368	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	5	44	theme	interface	823:831	arg1	states					833:838	good interface states	818:838	good interface states	818:838	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	6	45	theme	@	1084:1084	arg1	3:3:4					1107:1111	3:3:4	1107:1111	3:3:4	1107:1111	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	6	45	theme	@	1084:1084	arg1	diatomite/MCC/PVBCFs					1085:1104	BiVO4@diatomite/MCC/PVBCFs	1079:1104	BiVO4@diatomite/MCC/PVBCFs (3:3:4)	1079:1112	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	8	46	theme	@	1348:1348	arg1	diatomite/MCC/PVBCFs					1349:1368	18% BiVO4@diatomite/MCC/PVBCFs	1339:1368	18% BiVO4@diatomite/MCC/PVBCFs	1339:1368	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	0	47	theme	BiVO4	72:76	arg1	diatomite/MCC/PVBCFs					78:97	BiVO4@diatomite/MCC/PVBCFs	72:97	BiVO4@diatomite/MCC/PVBCFs for degradation of organic pollutants	72:135	Preparation of visible light-responsive photocatalytic paper containing BiVO4@diatomite/MCC/PVBCFs for degradation of organic pollutants.
32622307	9	48	theme	indoor	1562:1567	arg1	HCHO					1593:1596	HCHO	1593:1596	HCHO	1593:1596	This paper also had good physical properties and has the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO.
32622307	9	48	theme	indoor	1562:1567	arg1	pollutants					1573:1582	indoor air pollutants	1562:1582	indoor air pollutants	1562:1582	This paper also had good physical properties and has the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO.
32622307	4	49	theme	BiVO4	637:641	arg1	diatomite/MCC/PVBCFs					643:662	BiVO4@diatomite/MCC/PVBCFs	637:662	BiVO4@diatomite/MCC/PVBCFs	637:662	BiVO4@diatomite/MCC/PVBCFs were then mixed with pulp fibers to prepare the visible light-responsive photocatalytic paper.
32622307	2	50	theme	glycerin	362:369	arg1	solution					371:378	Bi(NO3)3·5H2O glycerin solution	348:378	Bi(NO3)3·5H2O glycerin solution	348:378	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	9	51	theme	pollutants	1573:1582	arg1	degradation					1547:1557	the photocatalytic degradation	1528:1557	the photocatalytic degradation of indoor air pollutants, such as HCHO	1528:1596	This paper also had good physical properties and has the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO.
32622307	3	52	theme	microcrystalline	545:560	arg1	MCC					573:575	MCC	573:575	MCC	573:575	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	3	52	theme	microcrystalline	545:560	arg1	cellulose					562:570	microcrystalline cellulose	545:570	microcrystalline cellulose (MCC)	545:576	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	5	53	theme	%	893:893	arg1	degradation					895:905	64.32% degradation	888:905	64.32% degradation of methylene blue (MB) after 4 h	888:938	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	3	54	theme	BiVO4	412:416	arg1	fibers					469:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers	412:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs)	412:503	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	3	54	theme	BiVO4	412:416	arg1	diatomite/MCC/PVBCFs					483:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	3	55	theme	PVB	582:584	arg1	solution					594:601	PVB ethanol solution	582:601	PVB ethanol solution	582:601	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	1	56	theme	organic	217:223	arg1	pollutants					225:234	degrading organic pollutants	207:234	degrading organic pollutants	207:234	Combining adsorption and photocatalysis is an effective strategy for degrading organic pollutants.
32622307	2	57	theme	hydrothermal	320:331	arg1	synthesis					333:341	hydrothermal synthesis	320:341	hydrothermal synthesis	320:341	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	5	58	theme	photocatalytic	859:872	arg1	activity					874:881	good photocatalytic activity	854:881	good photocatalytic activity	854:881	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	8	59	theme	photocatalytic	1379:1392	arg1	activity					1394:1401	good photocatalytic activity	1374:1401	good photocatalytic activity	1374:1401	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	5	60	theme	@	764:764	arg1	CP					775:776	BiVO4@diatomite CP	759:776	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4	759:812	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	2	61	theme	diatomite	249:257	arg1	CP					300:301	BiVO4@diatomite CP	284:301	BiVO4@diatomite CP	284:301	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	2	61	theme	diatomite	249:257	arg1	photocatalyst					269:281	BiVO4@diatomite composite photocatalyst	243:281	BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP)	243:302	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	6	62	theme	ethanol	947:953	arg1	solution					955:962	A PVB ethanol solution	941:962	A PVB ethanol solution (6%)	941:967	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	6	62	theme	ethanol	947:953	arg1	%					966:966	6%	965:966	6%	965:966	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	8	63	theme	%	1413:1413	arg1	degradation					1415:1425	50.20% degradation	1408:1425	50.20% degradation of HCHO	1408:1433	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	4	64	theme	photocatalytic	737:750	arg1	paper					752:756	the visible light-responsive photocatalytic paper	708:756	the visible light-responsive photocatalytic paper	708:756	BiVO4@diatomite/MCC/PVBCFs were then mixed with pulp fibers to prepare the visible light-responsive photocatalytic paper.
32622307	2	65	theme	diatomite	290:298	arg1	CP					300:301	BiVO4@diatomite CP	284:301	BiVO4@diatomite CP	284:301	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	2	65	theme	diatomite	290:298	arg1	photocatalyst					269:281	BiVO4@diatomite composite photocatalyst	243:281	BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP)	243:302	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	5	66	contain	had	814:816	arg1	CP					775:776	BiVO4@diatomite CP	759:776	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4	759:812	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	5	66	contain	had	814:816	arg2	states					833:838	good interface states	818:838	good interface states	818:838	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	9	67	theme	good	1466:1469	arg1	properties					1480:1489	good physical properties	1466:1489	good physical properties	1466:1489	This paper also had good physical properties and has the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO.
32622307	2	68	theme	BiVO4	284:288	arg1	CP					300:301	BiVO4@diatomite CP	284:301	BiVO4@diatomite CP	284:301	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	2	68	theme	BiVO4	284:288	arg1	photocatalyst					269:281	BiVO4@diatomite composite photocatalyst	243:281	BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP)	243:302	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	5	69	theme	blue	920:923	arg1	MB					926:927	MB	926:927	MB	926:927	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	5	69	theme	blue	920:923	arg1	methylene					910:918	methylene blue	910:923	methylene blue (MB) after 4 h	910:938	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	7	70	theme	compact	1157:1163	arg1	surfaces					1147:1154	smooth surfaces	1140:1154	smooth surfaces	1140:1154	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	7	70	theme	compact	1157:1163	arg1	structures					1165:1174	compact structures	1157:1174	compact structures	1157:1174	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	1	71	theme	effective	184:192	arg1	strategy					194:201	an effective strategy	181:201	an effective strategy for degrading organic pollutants	181:234	Combining adsorption and photocatalysis is an effective strategy for degrading organic pollutants.
32622307	6	72	theme	@	994:994	arg1	CP					1005:1006	BiVO4@diatomite CP	989:1006	BiVO4@diatomite CP	989:1006	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	4	73	theme	visible	712:718	arg1	paper					752:756	the visible light-responsive photocatalytic paper	708:756	the visible light-responsive photocatalytic paper	708:756	BiVO4@diatomite/MCC/PVBCFs were then mixed with pulp fibers to prepare the visible light-responsive photocatalytic paper.
32622307	0	74	theme	organic	118:124	arg1	pollutants					126:135	organic pollutants	118:135	organic pollutants	118:135	Preparation of visible light-responsive photocatalytic paper containing BiVO4@diatomite/MCC/PVBCFs for degradation of organic pollutants.
32622307	7	75	dep	%	1225:1225	arg1	degradation					1238:1248	degradation	1238:1248	degradation of MB and formaldehyde	1238:1271	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	7	76	theme	smooth	1140:1145	arg1	surfaces					1147:1154	smooth surfaces	1140:1154	smooth surfaces	1140:1154	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	7	76	theme	smooth	1140:1145	arg1	structures					1165:1174	compact structures	1157:1174	compact structures	1157:1174	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	7	77	theme	formaldehyde	1260:1271	arg1	degradation					1238:1248	degradation	1238:1248	degradation of MB and formaldehyde	1238:1271	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	8	78	contain	had	1370:1372	arg1	paper					1322:1326	Photocatalytic paper	1307:1326	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs	1307:1368	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	8	78	contain	had	1370:1372	arg2	activity					1394:1401	good photocatalytic activity	1374:1401	good photocatalytic activity	1374:1401	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	2	79	theme	NH4VO3	381:386	arg1	solution					388:395	NH4VO3 solution	381:395	NH4VO3 solution	381:395	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	0	80	theme	light-responsive	23:38	arg1	paper					55:59	visible light-responsive photocatalytic paper	15:59	visible light-responsive photocatalytic paper	15:59	Preparation of visible light-responsive photocatalytic paper containing BiVO4@diatomite/MCC/PVBCFs for degradation of organic pollutants.
32622307	6	81	theme	ethanol	1030:1036	arg1	solution					1047:1054	an ethanol spinning solution	1027:1054	an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4)	1027:1112	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	6	81	theme	ethanol	1030:1036	arg1	%					1059:1059	12% solid	1057:1065	12% solid	1057:1065	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	5	82	theme	6:4	810:812	arg1	ratio					801:805	a BiVO4/diatomite ratio	783:805	a BiVO4/diatomite ratio of 6:4	783:812	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	3	83	theme	diatomite/microcrystalline	418:443	arg1	fibers					469:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers	412:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs)	412:503	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	3	83	theme	diatomite/microcrystalline	418:443	arg1	diatomite/MCC/PVBCFs					483:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	3	84	theme	@	482:482	arg1	fibers					469:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers	412:474	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs)	412:503	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	3	84	theme	@	482:482	arg1	diatomite/MCC/PVBCFs					483:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/MCC/PVBCFs	477:502	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	5	85	theme	good	818:821	arg1	states					833:838	good interface states	818:838	good interface states	818:838	BiVO4@diatomite CP with a BiVO4/diatomite ratio of 6:4 had good interface states and displayed good photocatalytic activity with 64.32% degradation of methylene blue (MB) after 4 h.
32622307	8	86	contain	containing	1328:1337	arg1	paper					1322:1326	Photocatalytic paper	1307:1326	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs	1307:1368	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	8	86	contain	containing	1328:1337	arg2	diatomite/MCC/PVBCFs					1349:1368	18% BiVO4@diatomite/MCC/PVBCFs	1339:1368	18% BiVO4@diatomite/MCC/PVBCFs	1339:1368	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	2	87	theme	BiVO4	243:247	arg1	CP					300:301	BiVO4@diatomite CP	284:301	BiVO4@diatomite CP	284:301	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	2	87	theme	BiVO4	243:247	arg1	photocatalyst					269:281	BiVO4@diatomite composite photocatalyst	243:281	BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP)	243:302	Here, BiVO4@diatomite composite photocatalyst (BiVO4@diatomite CP) was prepared by hydrothermal synthesis from Bi(NO3)3·5H2O glycerin solution, NH4VO3 solution and diatomite.
32622307	8	88	theme	18	1339:1340	arg1	%					1341:1341	%	1341:1341	%	1341:1341	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	3	89	theme	BiVO4	524:528	arg1	CPs					540:542	BiVO4@diatomite CPs	524:542	BiVO4@diatomite CPs	524:542	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	9	90	theme	photocatalytic	1532:1545	arg1	degradation					1547:1557	the photocatalytic degradation	1528:1557	the photocatalytic degradation of indoor air pollutants, such as HCHO	1528:1596	This paper also had good physical properties and has the potential to be used for the photocatalytic degradation of indoor air pollutants, such as HCHO.
32622307	3	91	theme	electrospinning	613:627	arg1	method					629:634	the electrospinning method	609:634	the electrospinning method	609:634	BiVO4@diatomite/microcrystalline cellulose/PVB composite fibers (BiVO4@diatomite/MCC/PVBCFs) were prepared from BiVO4@diatomite CPs, microcrystalline cellulose (MCC) and PVB ethanol solution using the electrospinning method.
32622307	6	92	theme	BiVO4	1079:1083	arg1	3:3:4					1107:1111	3:3:4	1107:1111	3:3:4	1107:1111	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	6	92	theme	BiVO4	1079:1083	arg1	diatomite/MCC/PVBCFs					1085:1104	BiVO4@diatomite/MCC/PVBCFs	1079:1104	BiVO4@diatomite/MCC/PVBCFs (3:3:4)	1079:1112	A PVB ethanol solution (6%) was formulated with BiVO4@diatomite CP and MCC to provide an ethanol spinning solution (12% solid) to prepare BiVO4@diatomite/MCC/PVBCFs (3:3:4).
32622307	8	93	theme	BiVO4	1343:1347	arg1	diatomite/MCC/PVBCFs					1349:1368	18% BiVO4@diatomite/MCC/PVBCFs	1339:1368	18% BiVO4@diatomite/MCC/PVBCFs	1339:1368	Photocatalytic paper containing 18% BiVO4@diatomite/MCC/PVBCFs had good photocatalytic activity with 50.20% degradation of HCHO after 4 h.
32622307	4	94	theme	@	642:642	arg1	diatomite/MCC/PVBCFs					643:662	BiVO4@diatomite/MCC/PVBCFs	637:662	BiVO4@diatomite/MCC/PVBCFs	637:662	BiVO4@diatomite/MCC/PVBCFs were then mixed with pulp fibers to prepare the visible light-responsive photocatalytic paper.
32622307	7	95	theme	resulting	1119:1127	arg1	fibers					1129:1134	The resulting fibers	1115:1134	The resulting fibers	1115:1134	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
32622307	7	96	theme	photocatalytic	1195:1208	arg1	activity					1210:1217	good photocatalytic activity	1190:1217	good photocatalytic activity	1190:1217	The resulting fibers had smooth surfaces, compact structures and exhibited good photocatalytic activity (66.80% and 56.80% degradation of MB and formaldehyde (HCHO), respectively, after 4 h).
33788088	4	0	theme	positive	776:783	arg1	potential					790:798	positive zeta potential	776:798	positive zeta potential at circum-neutral pH	776:819	Chitin functionality in the composite has resulted in positive zeta potential at circum-neutral pH, favoring electrostatic attraction of chromate ions and resulting in its bulk surface transport.
33788088	7	1	from	leaching	1159:1166	arg1	process					1185:1191	the acid wash process	1171:1191	the acid wash process	1171:1191	No Cr (VI) leaching in the acid wash process at pH 3.5 also suggests chromium's strong chemisorption onto nanocomposite.
33788088	9	2	theme	spiked	1533:1538	arg1	mg/g					1563:1566	39.7 ± 0.04 mg/g	1551:1566	39.7 ± 0.04 mg/g	1551:1566	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	9	2	theme	spiked	1533:1538	arg1	solutions					1540:1548	both spiked solutions	1528:1548	both spiked solutions (39.7 ± 0.04 mg/g)	1528:1567	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	11	3	theme	continuous	1868:1877	arg1	Cr					1879:1880	continuous Cr	1868:1880	continuous Cr	1868:1880	The study concludes that HAP-Fe0-Ct could be utilized for continuous Cr (VI) removal from COPR contaminated complex groundwater matrices.
33788088	9	4	theme	column	1471:1476	arg1	extraction					1478:1487	Continuous column extraction	1460:1487	Continuous column extraction of chromate ions	1460:1504	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	8	5	theme	co-precipitation	1442:1457	arg1	reduction					1413:1421	the probable simultaneous reduction	1387:1421	the probable simultaneous reduction of Cr (VI) and its co-precipitation	1387:1457	During the interaction in aqueous solutions, the reduced iron (Fe0) on the nanocomposite becomes oxidized, suggesting the probable simultaneous reduction of Cr (VI) and its co-precipitation.
33788088	6	6	theme	interaction	1107:1117	arg1	time					1119:1122	interaction time	1107:1122	interaction time in groundwater samples	1107:1145	The composite has shown sorption equilibrium and 100% removal of Cr (VI) within 3 h of interaction time in groundwater samples.
33788088	6	7	from	h	1102:1102	arg1	samples					1139:1145	groundwater samples	1127:1145	groundwater samples	1127:1145	The composite has shown sorption equilibrium and 100% removal of Cr (VI) within 3 h of interaction time in groundwater samples.
33788088	6	8	theme	sorption	1044:1051	arg1	equilibrium					1053:1063	sorption equilibrium	1044:1063	sorption equilibrium	1044:1063	The composite has shown sorption equilibrium and 100% removal of Cr (VI) within 3 h of interaction time in groundwater samples.
33788088	2	9	dep	Cr	323:324	arg1	VI					327:328	VI	327:328	VI	327:328	It is of serious concern as Cr (VI) is proven to be carcinogenic.
33788088	11	10	theme	complex	1918:1924	arg1	matrices					1938:1945	complex groundwater matrices	1918:1945	complex groundwater matrices	1918:1945	The study concludes that HAP-Fe0-Ct could be utilized for continuous Cr (VI) removal from COPR contaminated complex groundwater matrices.
33788088	9	11	theme	ions	1501:1504	arg1	extraction					1478:1487	Continuous column extraction	1460:1487	Continuous column extraction of chromate ions	1460:1504	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	3	12	theme	complex	656:662	arg1	matrix					672:677	a complex aqueous matrix	654:677	a complex aqueous matrix having 793 mg/L of total dissolved solids	654:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	4	13	theme	electrostatic	831:843	arg1	attraction					845:854	electrostatic attraction	831:854	electrostatic attraction of chromate ions	831:871	Chitin functionality in the composite has resulted in positive zeta potential at circum-neutral pH, favoring electrostatic attraction of chromate ions and resulting in its bulk surface transport.
33788088	3	14	from	mg/L	646:649	arg1	matrix					672:677	a complex aqueous matrix	654:677	a complex aqueous matrix having 793 mg/L of total dissolved solids	654:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	5	15	theme	qm	984:985	arg1	efficiency					972:981	efficiency	972:981	efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI)	972:1017	The HAP-Fe0-Ct showed faster kinetics of removal with efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI).
33788088	5	15	theme	qm	984:985	arg1	mg/g					1001:1004	qm = 13.9 ± 0.46 mg/g	984:1004	qm = 13.9 ± 0.46 mg/g	984:1004	The HAP-Fe0-Ct showed faster kinetics of removal with efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI).
33788088	1	16	theme	real	207:210	arg1	residues					187:194	Chromite ore processing residues	163:194	Chromite ore processing residues (COPR)	163:201	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	1	16	theme	real	207:210	arg1	threats					226:232	real environmental threats	207:232	real environmental threats	207:232	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	0	17	theme	hydroxyapatite	133:146	arg1	nanocomposite					148:160	iron-enriched hydroxyapatite nanocomposite	119:160	iron-enriched hydroxyapatite nanocomposite	119:160	Removal of chromate ions from leachate-contaminated groundwater samples of Khan Chandpur, India, using chitin modified iron-enriched hydroxyapatite nanocomposite.
33788088	8	18	from	iron	1326:1329	arg1	nanocomposite					1344:1356	the nanocomposite	1340:1356	the nanocomposite	1340:1356	During the interaction in aqueous solutions, the reduced iron (Fe0) on the nanocomposite becomes oxidized, suggesting the probable simultaneous reduction of Cr (VI) and its co-precipitation.
33788088	4	19	theme	circum-neutral	803:816	arg1	pH					818:819	circum-neutral pH	803:819	circum-neutral pH	803:819	Chitin functionality in the composite has resulted in positive zeta potential at circum-neutral pH, favoring electrostatic attraction of chromate ions and resulting in its bulk surface transport.
33788088	10	20	theme	sites	1739:1743	arg1	generation					1745:1754	new binding sites generation	1727:1754	new binding sites generation	1727:1754	Reusability up to three cycles with almost complete Cr (VI) removal may be attributed to surface protonation, new binding sites generation, and electron transfer from Fe0 core through defects.
33788088	5	21	theme	removal	959:965	arg1	kinetics					947:954	faster kinetics	940:954	faster kinetics of removal with efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI)	940:1017	The HAP-Fe0-Ct showed faster kinetics of removal with efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI).
33788088	3	22	theme	groundwater	542:552	arg1	samples					554:560	Cr (VI)-contaminated groundwater samples	521:560	Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids	521:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	1	23	dep	Cr	260:261	arg1	i.e.					254:257	i.e.	254:257	i.e.	254:257	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	1	23	dep	Cr	260:261	arg1	leaching					268:275	leaching	268:275	Cr (VI) leaching into groundwater	260:292	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	1	23	dep	Cr	260:261	arg1	VI					264:265	VI	264:265	VI	264:265	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	7	24	theme	acid	1175:1178	arg1	process					1185:1191	the acid wash process	1171:1191	the acid wash process	1171:1191	No Cr (VI) leaching in the acid wash process at pH 3.5 also suggests chromium's strong chemisorption onto nanocomposite.
33788088	3	25	theme	dissolved	704:712	arg1	solids					714:719	total dissolved solids	698:719	total dissolved solids	698:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	6	26	theme	%	1072:1072	arg1	removal					1074:1080	100% removal	1069:1080	100% removal of Cr (VI)	1069:1091	The composite has shown sorption equilibrium and 100% removal of Cr (VI) within 3 h of interaction time in groundwater samples.
33788088	10	27	theme	electron	1761:1768	arg1	transfer					1770:1777	electron transfer	1761:1777	electron transfer from Fe0 core through defects	1761:1807	Reusability up to three cycles with almost complete Cr (VI) removal may be attributed to surface protonation, new binding sites generation, and electron transfer from Fe0 core through defects.
33788088	7	28	dep	suggests	1208:1215	arg1	VI					1155:1156	VI	1155:1156	VI	1155:1156	No Cr (VI) leaching in the acid wash process at pH 3.5 also suggests chromium's strong chemisorption onto nanocomposite.
33788088	9	29	from	solutions	1540:1548	arg1	efficient					1515:1523	efficient	1515:1523	efficient	1515:1523	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	4	30	theme	surface	899:905	arg1	transport					907:915	its bulk surface transport	890:915	its bulk surface transport	890:915	Chitin functionality in the composite has resulted in positive zeta potential at circum-neutral pH, favoring electrostatic attraction of chromate ions and resulting in its bulk surface transport.
33788088	8	31	theme	the reduced	1314:1324	arg1	Fe0					1332:1334	Fe0	1332:1334	Fe0	1332:1334	During the interaction in aqueous solutions, the reduced iron (Fe0) on the nanocomposite becomes oxidized, suggesting the probable simultaneous reduction of Cr (VI) and its co-precipitation.
33788088	8	31	theme	the reduced	1314:1324	arg1	iron					1326:1329	the reduced iron	1314:1329	the reduced iron (Fe0) on the nanocomposite	1314:1356	During the interaction in aqueous solutions, the reduced iron (Fe0) on the nanocomposite becomes oxidized, suggesting the probable simultaneous reduction of Cr (VI) and its co-precipitation.
33788088	1	32	theme	processing	176:185	arg1	COPR					197:200	COPR	197:200	COPR	197:200	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	1	32	theme	processing	176:185	arg1	residues					187:194	Chromite ore processing residues	163:194	Chromite ore processing residues (COPR)	163:201	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	1	32	theme	processing	176:185	arg1	threats					226:232	real environmental threats	207:232	real environmental threats	207:232	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	4	33	theme	ions	868:871	arg1	attraction					845:854	electrostatic attraction	831:854	electrostatic attraction of chromate ions	831:871	Chitin functionality in the composite has resulted in positive zeta potential at circum-neutral pH, favoring electrostatic attraction of chromate ions and resulting in its bulk surface transport.
33788088	11	34	dep	contaminated	1905:1916	arg1	VI					1883:1884	VI	1883:1884	VI	1883:1884	The study concludes that HAP-Fe0-Ct could be utilized for continuous Cr (VI) removal from COPR contaminated complex groundwater matrices.
33788088	3	35	contain	having	679:684	arg2	mg/L					690:693	793 mg/L	686:693	793 mg/L of total dissolved solids	686:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	3	35	contain	having	679:684	arg1	matrix					672:677	a complex aqueous matrix	654:677	a complex aqueous matrix having 793 mg/L of total dissolved solids	654:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	0	36	theme	India	90:94	arg1	samples					64:70	leachate-contaminated groundwater samples	30:70	leachate-contaminated groundwater samples	30:70	Removal of chromate ions from leachate-contaminated groundwater samples of Khan Chandpur, India, using chitin modified iron-enriched hydroxyapatite nanocomposite.
33788088	9	37	from	efficient	1515:1523	arg1	mg/g					1563:1566	39.7 ± 0.04 mg/g	1551:1566	39.7 ± 0.04 mg/g	1551:1566	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	9	37	from	efficient	1515:1523	arg1	solutions					1540:1548	both spiked solutions	1528:1548	both spiked solutions (39.7 ± 0.04 mg/g)	1528:1567	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	9	37	from	efficient	1515:1523	arg1	mg/g					1610:1613	13.2 ± 0.09 mg/g	1598:1613	13.2 ± 0.09 mg/g	1598:1613	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	9	37	from	efficient	1515:1523	arg1	water					1591:1595	COPR contaminated water	1573:1595	COPR contaminated water (13.2 ± 0.09 mg/g)	1573:1614	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	9	38	theme	contaminated	1578:1589	arg1	mg/g					1610:1613	13.2 ± 0.09 mg/g	1598:1613	13.2 ± 0.09 mg/g	1598:1613	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	9	38	theme	contaminated	1578:1589	arg1	water					1591:1595	COPR contaminated water	1573:1595	COPR contaminated water (13.2 ± 0.09 mg/g)	1573:1614	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	8	39	dep	Cr	1426:1427	arg1	VI					1430:1431	VI	1430:1431	VI	1430:1431	During the interaction in aqueous solutions, the reduced iron (Fe0) on the nanocomposite becomes oxidized, suggesting the probable simultaneous reduction of Cr (VI) and its co-precipitation.
33788088	11	40	used	utilized	1855:1862	arg2	HAP-Fe0-Ct					1835:1844	HAP-Fe0-Ct	1835:1844	HAP-Fe0-Ct	1835:1844	The study concludes that HAP-Fe0-Ct could be utilized for continuous Cr (VI) removal from COPR contaminated complex groundwater matrices.
33788088	0	41	theme	chromate	11:18	arg1	ions					20:23	chromate ions	11:23	chromate ions	11:23	Removal of chromate ions from leachate-contaminated groundwater samples of Khan Chandpur, India, using chitin modified iron-enriched hydroxyapatite nanocomposite.
33788088	7	42	theme	strong	1228:1233	arg1	chemisorption					1235:1247	chromium's strong chemisorption	1217:1247	chromium's strong chemisorption onto nanocomposite	1217:1266	No Cr (VI) leaching in the acid wash process at pH 3.5 also suggests chromium's strong chemisorption onto nanocomposite.
33788088	7	43	from	pH	1196:1197	arg1	leaching					1159:1166	leaching	1159:1166	leaching in the acid wash process at pH 3.5	1159:1201	No Cr (VI) leaching in the acid wash process at pH 3.5 also suggests chromium's strong chemisorption onto nanocomposite.
33788088	4	44	theme	Chitin	722:727	arg1	functionality					729:741	Chitin functionality	722:741	Chitin functionality in the composite	722:758	Chitin functionality in the composite has resulted in positive zeta potential at circum-neutral pH, favoring electrostatic attraction of chromate ions and resulting in its bulk surface transport.
33788088	5	45	theme	faster	940:945	arg1	kinetics					947:954	faster kinetics	940:954	faster kinetics of removal with efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI)	940:1017	The HAP-Fe0-Ct showed faster kinetics of removal with efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI).
33788088	11	46	theme	groundwater	1926:1936	arg1	matrices					1938:1945	complex groundwater matrices	1918:1945	complex groundwater matrices	1918:1945	The study concludes that HAP-Fe0-Ct could be utilized for continuous Cr (VI) removal from COPR contaminated complex groundwater matrices.
33788088	3	47	theme	iron-enriched	443:455	arg1	HAP-Fe0-Ct					487:496	HAP-Fe0-Ct	487:496	HAP-Fe0-Ct	487:496	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	3	47	theme	iron-enriched	443:455	arg1	nanocomposite					472:484	novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite	398:484	novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct)	398:497	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	0	48	theme	groundwater	52:62	arg1	samples					64:70	leachate-contaminated groundwater samples	30:70	leachate-contaminated groundwater samples	30:70	Removal of chromate ions from leachate-contaminated groundwater samples of Khan Chandpur, India, using chitin modified iron-enriched hydroxyapatite nanocomposite.
33788088	8	49	theme	simultaneous	1400:1411	arg1	reduction					1413:1421	the probable simultaneous reduction	1387:1421	the probable simultaneous reduction of Cr (VI) and its co-precipitation	1387:1457	During the interaction in aqueous solutions, the reduced iron (Fe0) on the nanocomposite becomes oxidized, suggesting the probable simultaneous reduction of Cr (VI) and its co-precipitation.
33788088	10	50	theme	complete	1660:1667	arg1	removal					1677:1683	almost complete Cr (VI) removal	1653:1683	almost complete Cr (VI) removal	1653:1683	Reusability up to three cycles with almost complete Cr (VI) removal may be attributed to surface protonation, new binding sites generation, and electron transfer from Fe0 core through defects.
33788088	3	51	theme	chitin	421:426	arg1	HAP-Fe0-Ct					487:496	HAP-Fe0-Ct	487:496	HAP-Fe0-Ct	487:496	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	3	51	theme	chitin	421:426	arg1	nanocomposite					472:484	novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite	398:484	novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct)	398:497	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	6	52	from	time	1119:1122	arg1	samples					1139:1145	groundwater samples	1127:1145	groundwater samples	1127:1145	The composite has shown sorption equilibrium and 100% removal of Cr (VI) within 3 h of interaction time in groundwater samples.
33788088	1	53	theme	Chromite	163:170	arg1	COPR					197:200	COPR	197:200	COPR	197:200	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	1	53	theme	Chromite	163:170	arg1	residues					187:194	Chromite ore processing residues	163:194	Chromite ore processing residues (COPR)	163:201	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	1	53	theme	Chromite	163:170	arg1	threats					226:232	real environmental threats	207:232	real environmental threats	207:232	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	6	54	theme	groundwater	1127:1137	arg1	samples					1139:1145	groundwater samples	1127:1145	groundwater samples	1127:1145	The composite has shown sorption equilibrium and 100% removal of Cr (VI) within 3 h of interaction time in groundwater samples.
33788088	3	55	from	application	383:393	arg1	remediation					506:516	the remediation	502:516	the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids	502:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	3	56	theme	nanocomposite	472:484	arg1	application					383:393	the application	379:393	the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids	379:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	9	57	theme	Continuous	1460:1469	arg1	extraction					1478:1487	Continuous column extraction	1460:1487	Continuous column extraction of chromate ions	1460:1504	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	6	58	theme	time	1119:1122	arg1	h					1102:1102	3 h	1100:1102	3 h of interaction time in groundwater samples	1100:1145	The composite has shown sorption equilibrium and 100% removal of Cr (VI) within 3 h of interaction time in groundwater samples.
33788088	4	59	theme	zeta	785:788	arg1	potential					790:798	positive zeta potential	776:798	positive zeta potential at circum-neutral pH	776:819	Chitin functionality in the composite has resulted in positive zeta potential at circum-neutral pH, favoring electrostatic attraction of chromate ions and resulting in its bulk surface transport.
33788088	11	60	from	COPR	1900:1903	arg1	removal					1887:1893	removal	1887:1893	removal from COPR	1887:1903	The study concludes that HAP-Fe0-Ct could be utilized for continuous Cr (VI) removal from COPR contaminated complex groundwater matrices.
33788088	9	61	theme	chromate	1492:1499	arg1	ions					1501:1504	chromate ions	1492:1504	chromate ions	1492:1504	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	10	62	theme	new	1727:1729	arg1	sites					1739:1743	new binding sites	1727:1743	new binding sites generation	1727:1754	Reusability up to three cycles with almost complete Cr (VI) removal may be attributed to surface protonation, new binding sites generation, and electron transfer from Fe0 core through defects.
33788088	3	63	dep	samples	554:560	arg1	VI					525:526	VI	525:526	VI	525:526	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	10	64	theme	Cr	1669:1670	arg1	removal					1677:1683	almost complete Cr (VI) removal	1653:1683	almost complete Cr (VI) removal	1653:1683	Reusability up to three cycles with almost complete Cr (VI) removal may be attributed to surface protonation, new binding sites generation, and electron transfer from Fe0 core through defects.
33788088	3	65	theme	aqueous	664:670	arg1	matrix					672:677	a complex aqueous matrix	654:677	a complex aqueous matrix having 793 mg/L of total dissolved solids	654:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	0	66	theme	iron-enriched	119:131	arg1	nanocomposite					148:160	iron-enriched hydroxyapatite nanocomposite	119:160	iron-enriched hydroxyapatite nanocomposite	119:160	Removal of chromate ions from leachate-contaminated groundwater samples of Khan Chandpur, India, using chitin modified iron-enriched hydroxyapatite nanocomposite.
33788088	3	67	theme	Cr	521:522	arg1	samples					554:560	Cr (VI)-contaminated groundwater samples	521:560	Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids	521:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	2	68	theme	serious	304:310	arg1	concern					312:318	serious concern	304:318	serious concern	304:318	It is of serious concern as Cr (VI) is proven to be carcinogenic.
33788088	5	69	theme	=	987:987	arg1	efficiency					972:981	efficiency	972:981	efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI)	972:1017	The HAP-Fe0-Ct showed faster kinetics of removal with efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI).
33788088	5	69	theme	=	987:987	arg1	mg/g					1001:1004	qm = 13.9 ± 0.46 mg/g	984:1004	qm = 13.9 ± 0.46 mg/g	984:1004	The HAP-Fe0-Ct showed faster kinetics of removal with efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI).
33788088	3	70	theme	samples	554:560	arg1	remediation					506:516	the remediation	502:516	the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids	502:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	1	71	theme	environmental	212:224	arg1	residues					187:194	Chromite ore processing residues	163:194	Chromite ore processing residues (COPR)	163:201	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	1	71	theme	environmental	212:224	arg1	threats					226:232	real environmental threats	207:232	real environmental threats	207:232	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	9	72	dep	contaminated	1578:1589	arg1	COPR					1573:1576	COPR	1573:1576	COPR	1573:1576	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	5	73	theme	±	994:994	arg1	efficiency					972:981	efficiency	972:981	efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI)	972:1017	The HAP-Fe0-Ct showed faster kinetics of removal with efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI).
33788088	5	73	theme	±	994:994	arg1	mg/g					1001:1004	qm = 13.9 ± 0.46 mg/g	984:1004	qm = 13.9 ± 0.46 mg/g	984:1004	The HAP-Fe0-Ct showed faster kinetics of removal with efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI).
33788088	3	74	theme	-contaminated	528:540	arg1	samples					554:560	Cr (VI)-contaminated groundwater samples	521:560	Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids	521:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	4	75	from	functionality	729:741	arg1	composite					750:758	the composite	746:758	the composite	746:758	Chitin functionality in the composite has resulted in positive zeta potential at circum-neutral pH, favoring electrostatic attraction of chromate ions and resulting in its bulk surface transport.
33788088	8	76	theme	aqueous	1295:1301	arg1	solutions					1303:1311	aqueous solutions	1295:1311	aqueous solutions	1295:1311	During the interaction in aqueous solutions, the reduced iron (Fe0) on the nanocomposite becomes oxidized, suggesting the probable simultaneous reduction of Cr (VI) and its co-precipitation.
33788088	6	77	theme	Cr	1085:1086	arg1	removal					1074:1080	100% removal	1069:1080	100% removal of Cr (VI)	1069:1091	The composite has shown sorption equilibrium and 100% removal of Cr (VI) within 3 h of interaction time in groundwater samples.
33788088	6	77	theme	Cr	1085:1086	arg1	equilibrium					1053:1063	sorption equilibrium	1044:1063	sorption equilibrium	1044:1063	The composite has shown sorption equilibrium and 100% removal of Cr (VI) within 3 h of interaction time in groundwater samples.
33788088	10	78	theme	binding	1731:1737	arg1	sites					1739:1743	new binding sites	1727:1743	new binding sites generation	1727:1754	Reusability up to three cycles with almost complete Cr (VI) removal may be attributed to surface protonation, new binding sites generation, and electron transfer from Fe0 core through defects.
33788088	4	79	from	pH	818:819	arg1	potential					790:798	positive zeta potential	776:798	positive zeta potential at circum-neutral pH	776:819	Chitin functionality in the composite has resulted in positive zeta potential at circum-neutral pH, favoring electrostatic attraction of chromate ions and resulting in its bulk surface transport.
33788088	7	80	theme	wash	1180:1183	arg1	process					1185:1191	the acid wash process	1171:1191	the acid wash process	1171:1191	No Cr (VI) leaching in the acid wash process at pH 3.5 also suggests chromium's strong chemisorption onto nanocomposite.
33788088	3	81	theme	solids	714:719	arg1	mg/L					690:693	793 mg/L	686:693	793 mg/L of total dissolved solids	686:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	8	82	from	interaction	1280:1290	arg1	solutions					1303:1311	aqueous solutions	1295:1311	aqueous solutions	1295:1311	During the interaction in aqueous solutions, the reduced iron (Fe0) on the nanocomposite becomes oxidized, suggesting the probable simultaneous reduction of Cr (VI) and its co-precipitation.
33788088	6	83	theme	100	1069:1071	arg1	%					1072:1072	%	1072:1072	%	1072:1072	The composite has shown sorption equilibrium and 100% removal of Cr (VI) within 3 h of interaction time in groundwater samples.
33788088	6	84	dep	Cr	1085:1086	arg1	VI					1089:1090	VI	1089:1090	VI	1089:1090	The composite has shown sorption equilibrium and 100% removal of Cr (VI) within 3 h of interaction time in groundwater samples.
33788088	3	85	theme	total	698:702	arg1	solids					714:719	total dissolved solids	698:719	total dissolved solids	698:719	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	1	86	theme	ore	172:174	arg1	COPR					197:200	COPR	197:200	COPR	197:200	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	1	86	theme	ore	172:174	arg1	residues					187:194	Chromite ore processing residues	163:194	Chromite ore processing residues (COPR)	163:201	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	1	86	theme	ore	172:174	arg1	threats					226:232	real environmental threats	207:232	real environmental threats	207:232	Chromite ore processing residues (COPR) are real environmental threats, leading to CrO42-, i.e., Cr (VI) leaching into groundwater.
33788088	4	87	theme	bulk	894:897	arg1	transport					907:915	its bulk surface transport	890:915	its bulk surface transport	890:915	Chitin functionality in the composite has resulted in positive zeta potential at circum-neutral pH, favoring electrostatic attraction of chromate ions and resulting in its bulk surface transport.
33788088	4	88	theme	chromate	859:866	arg1	ions					868:871	chromate ions	859:871	chromate ions	859:871	Chitin functionality in the composite has resulted in positive zeta potential at circum-neutral pH, favoring electrostatic attraction of chromate ions and resulting in its bulk surface transport.
33788088	0	89	from	samples	64:70	arg1	Removal					0:6	Removal	0:6	Removal of chromate ions from leachate-contaminated groundwater samples of Khan Chandpur, India, using chitin	0:108	Removal of chromate ions from leachate-contaminated groundwater samples of Khan Chandpur, India, using chitin modified iron-enriched hydroxyapatite nanocomposite.
33788088	10	90	theme	Fe0	1784:1786	arg1	core					1788:1791	Fe0 core	1784:1791	Fe0 core	1784:1791	Reusability up to three cycles with almost complete Cr (VI) removal may be attributed to surface protonation, new binding sites generation, and electron transfer from Fe0 core through defects.
33788088	5	91	with	removal	959:965	arg1	efficiency					972:981	efficiency	972:981	efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI)	972:1017	The HAP-Fe0-Ct showed faster kinetics of removal with efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI).
33788088	5	91	with	removal	959:965	arg1	mg/g					1001:1004	qm = 13.9 ± 0.46 mg/g	984:1004	qm = 13.9 ± 0.46 mg/g	984:1004	The HAP-Fe0-Ct showed faster kinetics of removal with efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI).
33788088	10	92	theme	surface	1706:1712	arg1	protonation					1714:1724	surface protonation	1706:1724	surface protonation	1706:1724	Reusability up to three cycles with almost complete Cr (VI) removal may be attributed to surface protonation, new binding sites generation, and electron transfer from Fe0 core through defects.
33788088	9	93	theme	13.2	1598:1601	arg1	±					1603:1603	±	1603:1603	±	1603:1603	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	0	94	theme	ions	20:23	arg1	Removal					0:6	Removal	0:6	Removal of chromate ions from leachate-contaminated groundwater samples of Khan Chandpur, India, using chitin	0:108	Removal of chromate ions from leachate-contaminated groundwater samples of Khan Chandpur, India, using chitin modified iron-enriched hydroxyapatite nanocomposite.
33788088	9	95	theme	0.09	1605:1608	arg1	±					1603:1603	±	1603:1603	±	1603:1603	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	5	96	dep	Cr	1011:1012	arg1	VI					1015:1016	VI	1015:1016	VI	1015:1016	The HAP-Fe0-Ct showed faster kinetics of removal with efficiency (qm = 13.9 ± 0.46 mg/g) for Cr (VI).
33788088	3	97	theme	eco-friendly	408:419	arg1	HAP-Fe0-Ct					487:496	HAP-Fe0-Ct	487:496	HAP-Fe0-Ct	487:496	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	3	97	theme	eco-friendly	408:419	arg1	nanocomposite					472:484	novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite	398:484	novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct)	398:497	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	0	98	theme	leachate-contaminated	30:50	arg1	samples					64:70	leachate-contaminated groundwater samples	30:70	leachate-contaminated groundwater samples	30:70	Removal of chromate ions from leachate-contaminated groundwater samples of Khan Chandpur, India, using chitin modified iron-enriched hydroxyapatite nanocomposite.
33788088	3	99	dep	found	629:633	arg1	VI					622:623	VI	622:623	VI	622:623	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	9	100	from	water	1591:1595	arg1	efficient					1515:1523	efficient	1515:1523	efficient	1515:1523	Continuous column extraction of chromate ions was also efficient in both spiked solutions (39.7 ± 0.04 mg/g) and COPR contaminated water (13.2 ± 0.09 mg/g).
33788088	8	101	theme	probable	1391:1398	arg1	reduction					1413:1421	the probable simultaneous reduction	1387:1421	the probable simultaneous reduction of Cr (VI) and its co-precipitation	1387:1457	During the interaction in aqueous solutions, the reduced iron (Fe0) on the nanocomposite becomes oxidized, suggesting the probable simultaneous reduction of Cr (VI) and its co-precipitation.
33788088	3	102	theme	novel	398:402	arg1	HAP-Fe0-Ct					487:496	HAP-Fe0-Ct	487:496	HAP-Fe0-Ct	487:496	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	3	102	theme	novel	398:402	arg1	nanocomposite					472:484	novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite	398:484	novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct)	398:497	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	6	103	from	samples	1139:1145	arg1	h					1102:1102	3 h	1100:1102	3 h of interaction time in groundwater samples	1100:1145	The composite has shown sorption equilibrium and 100% removal of Cr (VI) within 3 h of interaction time in groundwater samples.
33788088	10	104	from	core	1788:1791	arg1	transfer					1770:1777	electron transfer	1761:1777	electron transfer from Fe0 core through defects	1761:1807	Reusability up to three cycles with almost complete Cr (VI) removal may be attributed to surface protonation, new binding sites generation, and electron transfer from Fe0 core through defects.
33788088	10	104	from	core	1788:1791	arg1	generation					1745:1754	new binding sites generation	1727:1754	new binding sites generation	1727:1754	Reusability up to three cycles with almost complete Cr (VI) removal may be attributed to surface protonation, new binding sites generation, and electron transfer from Fe0 core through defects.
33788088	10	104	from	core	1788:1791	arg1	protonation					1714:1724	surface protonation	1706:1724	surface protonation	1706:1724	Reusability up to three cycles with almost complete Cr (VI) removal may be attributed to surface protonation, new binding sites generation, and electron transfer from Fe0 core through defects.
33788088	10	105	dep	removal	1677:1683	arg1	VI					1673:1674	VI	1673:1674	VI	1673:1674	Reusability up to three cycles with almost complete Cr (VI) removal may be attributed to surface protonation, new binding sites generation, and electron transfer from Fe0 core through defects.
33788088	3	106	theme	Cr	618:619	arg1	level					609:613	the level	605:613	the level of Cr	605:619	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	3	106	theme	Cr	618:619	arg1	mg/L					646:649	11.7 mg/L	641:649	11.7 mg/L	641:649	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	3	107	theme	hydroxyapatite	457:470	arg1	HAP-Fe0-Ct					487:496	HAP-Fe0-Ct	487:496	HAP-Fe0-Ct	487:496	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	3	107	theme	hydroxyapatite	457:470	arg1	nanocomposite					472:484	novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite	398:484	novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct)	398:497	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	10	108	with	cycles	1641:1646	arg1	removal					1677:1683	almost complete Cr (VI) removal	1653:1683	almost complete Cr (VI) removal	1653:1683	Reusability up to three cycles with almost complete Cr (VI) removal may be attributed to surface protonation, new binding sites generation, and electron transfer from Fe0 core through defects.
33788088	8	109	theme	Cr	1426:1427	arg1	reduction					1413:1421	the probable simultaneous reduction	1387:1421	the probable simultaneous reduction of Cr (VI) and its co-precipitation	1387:1457	During the interaction in aqueous solutions, the reduced iron (Fe0) on the nanocomposite becomes oxidized, suggesting the probable simultaneous reduction of Cr (VI) and its co-precipitation.
33788088	3	110	theme	functionalized	428:441	arg1	HAP-Fe0-Ct					487:496	HAP-Fe0-Ct	487:496	HAP-Fe0-Ct	487:496	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
33788088	3	110	theme	functionalized	428:441	arg1	nanocomposite					472:484	novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite	398:484	novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct)	398:497	Here we emphasize the application of novel and eco-friendly chitin functionalized iron-enriched hydroxyapatite nanocomposite (HAP-Fe0-Ct) in the remediation of Cr (VI)-contaminated groundwater samples collected from Khan Chandpur, India, where the level of Cr (VI) is found to be 11.7 mg/L in a complex aqueous matrix having 793 mg/L of total dissolved solids.
34955268	7	0	theme	casein	1175:1180	arg1	enrichments					1117:1127	Isotopic enrichments	1108:1127	Isotopic enrichments of plasma Leu, keto-isocaproic acid, and milk casein	1108:1180	Isotopic enrichments of plasma Leu, keto-isocaproic acid, and milk casein were determined for calculation of Leu kinetics.
34955268	4	1	theme	crude	774:778	arg1	matter					799:804	15.5% dry matter	789:804	15.5% dry matter	789:804	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	4	1	theme	crude	774:778	arg1	protein					780:786	dietary crude protein	766:786	dietary crude protein (15.5% dry matter)	766:805	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	17	2	theme	body	2570:2573	arg1	fat					2575:2577	body fat	2570:2577	body fat	2570:2577	In LS-fed cows, higher mobilization of body fat and protein was confirmed by the greater body weight loss in both stages of lactation.
34955268	3	3	theme	same	635:638	arg1	stage					640:644	the same stage	631:644	the same stage of lactation	631:657	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	0	4	theme	Holstein	151:158	arg1	cows					166:169	Holstein dairy cows	151:169	Holstein dairy cows	151:169	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	2	5	theme	given	334:338	arg1	diet					340:343	a given diet	332:343	a given diet	332:343	Those factors determine nutrient availability from a given diet, and once absorbed, they interact with the endocrine system and together determine availability of metabolites to the mammary gland.
34955268	1	6	theme	chemical	225:232	arg1	characteristics					234:248	chemical characteristics	225:248	chemical characteristics	225:248	Milk yield and composition are modified by level and chemical characteristics of dietary energy and protein.
34955268	14	7	theme	dietary	2083:2089	arg1	groups					2091:2096	dietary groups	2083:2096	dietary groups in early lactation	2083:2115	However, for most of the essential AA (particularly branched-chain), the HS diet led to a marked decrease in concentrations after the forage meal, resulting in significant differences between dietary groups in early lactation.
34955268	17	8	theme	protein	2583:2589	arg1	mobilization					2554:2565	higher mobilization	2547:2565	higher mobilization of body fat and protein	2547:2589	In LS-fed cows, higher mobilization of body fat and protein was confirmed by the greater body weight loss in both stages of lactation.
34955268	19	9	theme	lower	2962:2966	arg1	rate					2981:2984	lower curd firming rate	2962:2984	lower curd firming rate	2962:2984	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	7	10	theme	acid	1160:1163	arg1	enrichments					1117:1127	Isotopic enrichments	1108:1127	Isotopic enrichments of plasma Leu, keto-isocaproic acid, and milk casein	1108:1180	Isotopic enrichments of plasma Leu, keto-isocaproic acid, and milk casein were determined for calculation of Leu kinetics.
34955268	7	11	theme	Isotopic	1108:1115	arg1	enrichments					1117:1127	Isotopic enrichments	1108:1127	Isotopic enrichments of plasma Leu, keto-isocaproic acid, and milk casein	1108:1180	Isotopic enrichments of plasma Leu, keto-isocaproic acid, and milk casein were determined for calculation of Leu kinetics.
34955268	15	12	theme	%	2318:2318	arg1	decreases					2294:2302	decreases	2294:2302	decreases of 27.9%, 33.6%, and 38.5%, respectively	2294:2343	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	19	13	theme	curd	3003:3006	arg1	firmness					3008:3015	higher curd firmness	2996:3015	higher curd firmness	2996:3015	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	3	14	theme	early	509:513	arg1	lactation					515:523	early lactation	509:523	early lactation	509:523	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	4	15	theme	similar	758:764	arg1	content					862:868	similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content	758:868	similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content	758:868	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	16	16	theme	bovine	2355:2360	arg1	ratio					2383:2387	A higher bovine somatotropin/insulin ratio	2346:2387	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS	2346:2425	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS could possibly have led to greater breakdown and, consequently, higher AA flux from peripheral tissues.
34955268	17	17	theme	fat	2575:2577	arg1	mobilization					2554:2565	higher mobilization	2547:2565	higher mobilization of body fat and protein	2547:2589	In LS-fed cows, higher mobilization of body fat and protein was confirmed by the greater body weight loss in both stages of lactation.
34955268	3	18	theme	feed	697:700	arg1	feed					697:700	rumen fermentable feed	679:700	rumen fermentable feed with either high (HS) or low starch (LS)	679:741	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	3	18	theme	feed	697:700	arg1	amounts					668:674	similar amounts	660:674	similar amounts of rumen fermentable feed with either high (HS) or low starch (LS)	660:741	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	14	19	theme	HS	1964:1965	arg1	diet					1967:1970	the HS diet	1960:1970	the HS diet	1960:1970	However, for most of the essential AA (particularly branched-chain), the HS diet led to a marked decrease in concentrations after the forage meal, resulting in significant differences between dietary groups in early lactation.
34955268	11	20	theme	milk	1702:1705	arg1	content					1711:1717	greater milk fat content	1694:1717	greater milk fat content in LS-fed cows	1694:1732	This response was associated with greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows.
34955268	15	21	theme	%	2329:2329	arg1	decreases					2294:2302	decreases	2294:2302	decreases of 27.9%, 33.6%, and 38.5%, respectively	2294:2343	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	6	22	dep	samples	1001:1007	arg1	was					956:958	was	956:958	was	956:958	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	6	22	dep	samples	1001:1007	arg1	infused					960:966	infused	960:966	infused	960:966	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	6	22	dep	samples	1001:1007	arg1	into					968:971	into	968:971	into	968:971	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	6	22	dep	samples	1001:1007	arg1	[1-13C					944:949	[1-13C	944:949	[1-13C	944:949	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	6	22	dep	samples	1001:1007	arg1	one					973:975	one	973:975	one	973:975	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	6	22	dep	samples	1001:1007	arg1	jugular					977:983	jugular	977:983	jugular	977:983	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	6	22	dep	samples	1001:1007	arg1	vein					985:988	vein	985:988	vein	985:988	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	6	22	dep	samples	1001:1007	arg1	with					990:993	with	990:993	with	990:993	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	6	22	dep	samples	1001:1007	arg1	Leu					952:954	Leu	952:954	Leu	952:954	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	3	23	theme	rumen	679:683	arg1	feed					697:700	rumen fermentable feed	679:700	rumen fermentable feed with either high (HS) or low starch (LS)	679:741	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	3	24	theme	multiparous	483:493	arg1	cows					501:504	Four multiparous dairy cows	478:504	Four multiparous dairy cows in early lactation and subsequently in late lactation	478:558	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	4	25	theme	protein	830:836	arg1	content					862:868	similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content	758:868	similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content	758:868	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	0	26	theme	milk	120:123	arg1	yield					125:129	milk yield	120:129	milk yield	120:129	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	10	27	theme	Feeding	1451:1457	arg1	LS					1459:1460	Feeding LS	1451:1460	Feeding LS	1451:1460	Feeding LS resulted in lower blood glucose and greater ratio of bovine somatotropin to insulin.
34955268	4	28	theme	%	793:793	arg1	matter					799:804	15.5% dry matter	789:804	15.5% dry matter	789:804	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	4	28	theme	%	793:793	arg1	protein					780:786	dietary crude protein	766:786	dietary crude protein (15.5% dry matter)	766:805	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	13	29	theme	average	1854:1860	arg1	concentrations					1869:1882	average plasma concentrations	1854:1882	average plasma concentrations of AA	1854:1888	Diet did not alter average plasma concentrations of AA.
34955268	15	30	located	observed	2249:2256	arg1	cows					2137:2140	early-lactating cows	2121:2140	early-lactating cows fed HS	2121:2147	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	15	30	located	observed	2249:2256	arg2	reduction					2160:2168	a greater reduction	2150:2168	a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero)	2150:2243	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	19	31	dep	faster	2954:2959	arg1	rate					2981:2984	lower curd firming rate	2962:2984	lower curd firming rate	2962:2984	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	4	32	contain	had	754:756	arg2	content					862:868	similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content	758:868	similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content	758:868	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	4	32	contain	had	754:756	arg1	diets					748:752	All diets	744:752	All diets	744:752	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	9	33	theme	matter	1378:1383	arg1	intake					1385:1390	Dry matter intake	1374:1390	Dry matter intake within each stage of lactation	1374:1421	Dry matter intake within each stage of lactation was similar between groups.
34955268	3	34	theme	low	727:729	arg1	LS					739:740	LS	739:740	LS	739:740	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	3	34	theme	low	727:729	arg1	starch					731:736	either high (HS) or low starch	707:736	either high (HS) or low starch (LS)	707:741	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	10	35	theme	lower	1474:1478	arg1	glucose					1486:1492	lower blood glucose	1474:1492	lower blood glucose	1474:1492	Feeding LS resulted in lower blood glucose and greater ratio of bovine somatotropin to insulin.
34955268	4	36	theme	protein	853:859	arg1	%					842:842	∼40%	839:842	∼40% of crude protein	839:859	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	4	36	theme	protein	853:859	arg1	protein					853:859	crude protein	847:859	crude protein	847:859	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	0	37	theme	content	48:54	arg1	stage					10:14	stage	10:14	stage of lactation and dietary starch content	10:54	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	11	38	theme	acids	1633:1637	arg1	concentrations					1595:1608	greater blood concentrations	1581:1608	greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows	1581:1732	This response was associated with greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows.
34955268	13	39	theme	AA	1887:1888	arg1	concentrations					1869:1882	average plasma concentrations	1854:1882	average plasma concentrations of AA	1854:1888	Diet did not alter average plasma concentrations of AA.
34955268	2	40	theme	mammary	463:469	arg1	gland					471:475	the mammary gland	459:475	the mammary gland	459:475	Those factors determine nutrient availability from a given diet, and once absorbed, they interact with the endocrine system and together determine availability of metabolites to the mammary gland.
34955268	14	41	from	groups	2091:2096	arg1	lactation					2107:2115	early lactation	2101:2115	early lactation	2101:2115	However, for most of the essential AA (particularly branched-chain), the HS diet led to a marked decrease in concentrations after the forage meal, resulting in significant differences between dietary groups in early lactation.
34955268	19	42	theme	milk	2933:2936	arg1	coagulation					2938:2948	milk coagulation	2933:2948	milk coagulation	2933:2948	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	19	43	theme	protein	2836:2842	arg1	output					2844:2849	protein output	2836:2849	protein output	2836:2849	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	0	44	theme	endocrine-metabolic	59:77	arg1	status					79:84	endocrine-metabolic status	59:84	endocrine-metabolic status	59:84	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	18	45	theme	late	2808:2811	arg1	lactation					2813:2821	late lactation	2808:2821	late lactation	2808:2821	Higher irreversible loss of [1-13C] Leu in early lactation suggested lower protein retention in peripheral tissues during early compared with late lactation.
34955268	9	46	theme	lactation	1413:1421	arg1	stage					1404:1408	each stage	1399:1408	each stage of lactation	1399:1421	Dry matter intake within each stage of lactation was similar between groups.
34955268	0	47	from	Effect	0:5	arg1	concentrations					104:117	blood amino acid concentrations	87:117	blood amino acid concentrations	87:117	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	0	47	from	Effect	0:5	arg1	yield					125:129	milk yield	120:129	milk yield	120:129	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	0	47	from	Effect	0:5	arg1	composition					136:146	composition	136:146	composition	136:146	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	0	47	from	Effect	0:5	arg1	status					79:84	endocrine-metabolic status	59:84	endocrine-metabolic status	59:84	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	15	48	from	reduction	2160:2168	arg1	concentrations					2180:2193	plasma concentrations	2173:2193	plasma concentrations at 8 h relative to pre-feeding values (time zero)	2173:2243	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	15	48	from	reduction	2160:2168	arg1	h					2200:2200	8 h	2198:2200	8 h	2198:2200	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	0	49	theme	amino	93:97	arg1	concentrations					104:117	blood amino acid concentrations	87:117	blood amino acid concentrations	87:117	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	12	50	from	concentrations	1759:1772	arg1	blood					1787:1791	blood	1787:1791	blood	1787:1791	Except for His, average concentrations of all AA in blood were higher in late than early lactation.
34955268	18	51	from	retention	2749:2757	arg1	tissues					2773:2779	peripheral tissues	2762:2779	peripheral tissues	2762:2779	Higher irreversible loss of [1-13C] Leu in early lactation suggested lower protein retention in peripheral tissues during early compared with late lactation.
34955268	20	52	from	fermentability	3112:3125	arg1	rumen					3134:3138	the rumen	3130:3138	the rumen	3130:3138	Overall, data indicated that rate of carbohydrate fermentability in the rumen can modify the availability of metabolites to the mammary gland and consequently modify milk protein coagulation.
34955268	19	53	theme	feeding	3032:3038	arg1	HS					3040:3041	feeding HS	3032:3041	feeding HS	3032:3041	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	1	54	theme	dietary	253:259	arg1	energy					261:266	dietary energy	253:266	dietary energy	253:266	Milk yield and composition are modified by level and chemical characteristics of dietary energy and protein.
34955268	3	55	with	feed	697:700	arg1	LS					739:740	LS	739:740	LS	739:740	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	3	55	with	feed	697:700	arg1	starch					731:736	either high (HS) or low starch	707:736	either high (HS) or low starch (LS)	707:741	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	18	56	theme	lower	2735:2739	arg1	retention					2749:2757	lower protein retention	2735:2757	lower protein retention in peripheral tissues	2735:2779	Higher irreversible loss of [1-13C] Leu in early lactation suggested lower protein retention in peripheral tissues during early compared with late lactation.
34955268	17	57	theme	greater	2612:2618	arg1	loss					2632:2635	the greater body weight loss	2608:2635	the greater body weight loss in both stages of lactation	2608:2663	In LS-fed cows, higher mobilization of body fat and protein was confirmed by the greater body weight loss in both stages of lactation.
34955268	20	58	from	rumen	3134:3138	arg1	rate					3091:3094	rate	3091:3094	rate of carbohydrate fermentability in the rumen	3091:3138	Overall, data indicated that rate of carbohydrate fermentability in the rumen can modify the availability of metabolites to the mammary gland and consequently modify milk protein coagulation.
34955268	2	59	theme	endocrine	388:396	arg1	system					398:403	the endocrine system	384:403	the endocrine system	384:403	Those factors determine nutrient availability from a given diet, and once absorbed, they interact with the endocrine system and together determine availability of metabolites to the mammary gland.
34955268	0	60	theme	stage	10:14	arg1	Effect					0:5	Effect	0:5	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.	0:170	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	13	61	theme	plasma	1862:1867	arg1	concentrations					1869:1882	average plasma concentrations	1854:1882	average plasma concentrations of AA	1854:1888	Diet did not alter average plasma concentrations of AA.
34955268	14	62	from	decrease	1988:1995	arg1	concentrations					2000:2013	concentrations	2000:2013	concentrations after the forage meal	2000:2035	However, for most of the essential AA (particularly branched-chain), the HS diet led to a marked decrease in concentrations after the forage meal, resulting in significant differences between dietary groups in early lactation.
34955268	7	63	theme	kinetics	1221:1228	arg1	calculation					1202:1212	calculation	1202:1212	calculation of Leu kinetics	1202:1228	Isotopic enrichments of plasma Leu, keto-isocaproic acid, and milk casein were determined for calculation of Leu kinetics.
34955268	10	64	theme	greater	1498:1504	arg1	ratio					1506:1510	greater ratio	1498:1510	greater ratio of bovine somatotropin to insulin	1498:1544	Feeding LS resulted in lower blood glucose and greater ratio of bovine somatotropin to insulin.
34955268	15	65	from	h	2200:2200	arg1	reduction					2160:2168	a greater reduction	2150:2168	a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero)	2150:2243	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	15	65	from	h	2200:2200	arg1	concentrations					2180:2193	plasma concentrations	2173:2193	plasma concentrations at 8 h relative to pre-feeding values (time zero)	2173:2243	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	6	66	theme	infusion	1098:1105	arg1	start					1089:1093	start	1089:1093	start of infusion	1089:1105	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	0	67	theme	lactation	19:27	arg1	stage					10:14	stage	10:14	stage of lactation and dietary starch content	10:54	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	19	68	dep	HS	3040:3041	arg1	response					3020:3027	response	3020:3027	response	3020:3027	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	3	69	theme	changeover	591:600	arg1	design					602:607	a changeover design	589:607	a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS)	589:741	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	20	70	theme	milk	3228:3231	arg1	coagulation					3241:3251	milk protein coagulation	3228:3251	milk protein coagulation	3228:3251	Overall, data indicated that rate of carbohydrate fermentability in the rumen can modify the availability of metabolites to the mammary gland and consequently modify milk protein coagulation.
34955268	14	71	theme	significant	2051:2061	arg1	differences					2063:2073	significant differences	2051:2073	significant differences between dietary groups in early lactation	2051:2115	However, for most of the essential AA (particularly branched-chain), the HS diet led to a marked decrease in concentrations after the forage meal, resulting in significant differences between dietary groups in early lactation.
34955268	0	72	theme	dietary	33:39	arg1	content					48:54	dietary starch content	33:54	dietary starch content	33:54	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	19	73	theme	Milk	2824:2827	arg1	yield					2829:2833	Milk yield	2824:2833	Milk yield	2824:2833	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	10	74	theme	somatotropin	1522:1533	arg1	glucose					1486:1492	lower blood glucose	1474:1492	lower blood glucose	1474:1492	Feeding LS resulted in lower blood glucose and greater ratio of bovine somatotropin to insulin.
34955268	10	74	theme	somatotropin	1522:1533	arg1	ratio					1506:1510	greater ratio	1498:1510	greater ratio of bovine somatotropin to insulin	1498:1544	Feeding LS resulted in lower blood glucose and greater ratio of bovine somatotropin to insulin.
34955268	14	75	theme	forage	2025:2030	arg1	meal					2032:2035	the forage meal	2021:2035	the forage meal	2021:2035	However, for most of the essential AA (particularly branched-chain), the HS diet led to a marked decrease in concentrations after the forage meal, resulting in significant differences between dietary groups in early lactation.
34955268	6	76	from	cows	1043:1046	arg1	d					938:938	d 28	938:941	d 28	938:941	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	8	77	with	procedure	1276:1284	arg1	time					1320:1323	time	1320:1323	time	1320:1323	Data were subjected to ANOVA using the MIXED procedure of SAS (SAS Institute Inc.), with time as repeated factor and cow as the random effect.
34955268	3	78	theme	dairy	495:499	arg1	cows					501:504	Four multiparous dairy cows	478:504	Four multiparous dairy cows in early lactation and subsequently in late lactation	478:558	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	16	79	theme	peripheral	2511:2520	arg1	tissues					2522:2528	peripheral tissues	2511:2528	peripheral tissues	2511:2528	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS could possibly have led to greater breakdown and, consequently, higher AA flux from peripheral tissues.
34955268	7	80	theme	milk	1170:1173	arg1	casein					1175:1180	milk casein	1170:1180	milk casein	1170:1180	Isotopic enrichments of plasma Leu, keto-isocaproic acid, and milk casein were determined for calculation of Leu kinetics.
34955268	5	81	theme	AA	883:884	arg1	Profiles					871:878	Profiles	871:878	Profiles of AA	871:884	Profiles of AA were calculated to be similar to that of casein.
34955268	8	82	theme	SAS	1289:1291	arg1	procedure					1276:1284	the MIXED procedure	1266:1284	the MIXED procedure	1266:1284	Data were subjected to ANOVA using the MIXED procedure of SAS (SAS Institute Inc.), with time as repeated factor and cow as the random effect.
34955268	8	82	theme	SAS	1289:1291	arg1	effect					1366:1371	the random effect	1355:1371	the random effect	1355:1371	Data were subjected to ANOVA using the MIXED procedure of SAS (SAS Institute Inc.), with time as repeated factor and cow as the random effect.
34955268	3	83	theme	lactation	649:657	arg1	stage					640:644	the same stage	631:644	the same stage of lactation	631:657	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	0	84	theme	dairy	160:164	arg1	cows					166:169	Holstein dairy cows	151:169	Holstein dairy cows	151:169	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	8	85	theme	repeated	1328:1335	arg1	factor					1337:1342	repeated factor	1328:1342	repeated factor	1328:1342	Data were subjected to ANOVA using the MIXED procedure of SAS (SAS Institute Inc.), with time as repeated factor and cow as the random effect.
34955268	4	86	theme	dietary	766:772	arg1	matter					799:804	15.5% dry matter	789:804	15.5% dry matter	789:804	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	4	86	theme	dietary	766:772	arg1	protein					780:786	dietary crude protein	766:786	dietary crude protein (15.5% dry matter)	766:805	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	16	87	from	tissues	2522:2528	arg1	flux					2501:2504	higher AA flux	2491:2504	higher AA flux from peripheral tissues	2491:2528	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS could possibly have led to greater breakdown and, consequently, higher AA flux from peripheral tissues.
34955268	16	87	from	tissues	2522:2528	arg1	breakdown					2462:2470	greater breakdown	2454:2470	greater breakdown	2454:2470	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS could possibly have led to greater breakdown and, consequently, higher AA flux from peripheral tissues.
34955268	0	88	from	composition	136:146	arg1	cows					166:169	Holstein dairy cows	151:169	Holstein dairy cows	151:169	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	14	89	theme	marked	1981:1986	arg1	decrease					1988:1995	a marked decrease	1979:1995	a marked decrease in concentrations after the forage meal	1979:2035	However, for most of the essential AA (particularly branched-chain), the HS diet led to a marked decrease in concentrations after the forage meal, resulting in significant differences between dietary groups in early lactation.
34955268	15	90	theme	greater	2152:2158	arg1	reduction					2160:2168	a greater reduction	2150:2168	a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero)	2150:2243	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	11	91	theme	greater	1694:1700	arg1	content					1711:1717	greater milk fat content	1694:1717	greater milk fat content in LS-fed cows	1694:1732	This response was associated with greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows.
34955268	7	92	theme	keto-isocaproic	1144:1158	arg1	acid					1160:1163	keto-isocaproic acid	1144:1163	keto-isocaproic acid	1144:1163	Isotopic enrichments of plasma Leu, keto-isocaproic acid, and milk casein were determined for calculation of Leu kinetics.
34955268	4	93	theme	protein	780:786	arg1	content					862:868	similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content	758:868	similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content	758:868	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	7	94	theme	plasma	1132:1137	arg1	Leu					1139:1141	plasma Leu	1132:1141	plasma Leu	1132:1141	Isotopic enrichments of plasma Leu, keto-isocaproic acid, and milk casein were determined for calculation of Leu kinetics.
34955268	16	95	theme	greater	2454:2460	arg1	breakdown					2462:2470	greater breakdown	2454:2470	greater breakdown	2454:2470	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS could possibly have led to greater breakdown and, consequently, higher AA flux from peripheral tissues.
34955268	3	96	from	cows	501:504	arg1	lactation					515:523	early lactation	509:523	early lactation	509:523	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	3	96	from	cows	501:504	arg1	lactation					550:558	late lactation	545:558	late lactation	545:558	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	7	97	theme	Leu	1139:1141	arg1	enrichments					1117:1127	Isotopic enrichments	1108:1127	Isotopic enrichments of plasma Leu, keto-isocaproic acid, and milk casein	1108:1180	Isotopic enrichments of plasma Leu, keto-isocaproic acid, and milk casein were determined for calculation of Leu kinetics.
34955268	6	98	theme	blood	995:999	arg1	samples					1001:1007	blood samples	995:1007	blood samples taken at 0, 2, 4, 6, and 8 h	995:1036	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	3	99	theme	similar	660:666	arg1	feed					697:700	rumen fermentable feed	679:700	rumen fermentable feed with either high (HS) or low starch (LS)	679:741	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	3	99	theme	similar	660:666	arg1	amounts					668:674	similar amounts	660:674	similar amounts of rumen fermentable feed with either high (HS) or low starch (LS)	660:741	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	15	100	theme	%	2311:2311	arg1	decreases					2294:2302	decreases	2294:2302	decreases of 27.9%, 33.6%, and 38.5%, respectively	2294:2343	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	3	101	theme	late	545:548	arg1	lactation					550:558	late lactation	545:558	late lactation	545:558	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	8	102	theme	random	1359:1364	arg1	procedure					1276:1284	the MIXED procedure	1266:1284	the MIXED procedure	1266:1284	Data were subjected to ANOVA using the MIXED procedure of SAS (SAS Institute Inc.), with time as repeated factor and cow as the random effect.
34955268	8	102	theme	random	1359:1364	arg1	effect					1366:1371	the random effect	1355:1371	the random effect	1355:1371	Data were subjected to ANOVA using the MIXED procedure of SAS (SAS Institute Inc.), with time as repeated factor and cow as the random effect.
34955268	16	103	theme	higher	2348:2353	arg1	ratio					2383:2387	A higher bovine somatotropin/insulin ratio	2346:2387	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS	2346:2425	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS could possibly have led to greater breakdown and, consequently, higher AA flux from peripheral tissues.
34955268	12	104	theme	AA	1781:1782	arg1	concentrations					1759:1772	average concentrations	1751:1772	average concentrations of all AA in blood	1751:1791	Except for His, average concentrations of all AA in blood were higher in late than early lactation.
34955268	16	105	theme	early	2392:2396	arg1	lactation					2398:2406	early lactation	2392:2406	early lactation	2392:2406	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS could possibly have led to greater breakdown and, consequently, higher AA flux from peripheral tissues.
34955268	17	106	theme	higher	2547:2552	arg1	mobilization					2554:2565	higher mobilization	2547:2565	higher mobilization of body fat and protein	2547:2589	In LS-fed cows, higher mobilization of body fat and protein was confirmed by the greater body weight loss in both stages of lactation.
34955268	15	107	theme	pre-feeding	2214:2224	arg1	time					2234:2237	time zero	2234:2242	time zero	2234:2242	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	15	107	theme	pre-feeding	2214:2224	arg1	values					2226:2231	pre-feeding values	2214:2231	pre-feeding values (time zero)	2214:2243	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	1	108	theme	Milk	172:175	arg1	yield					177:181	Milk yield	172:181	Milk yield	172:181	Milk yield and composition are modified by level and chemical characteristics of dietary energy and protein.
34955268	17	109	theme	weight	2625:2630	arg1	loss					2632:2635	the greater body weight loss	2608:2635	the greater body weight loss in both stages of lactation	2608:2663	In LS-fed cows, higher mobilization of body fat and protein was confirmed by the greater body weight loss in both stages of lactation.
34955268	1	110	mod	modified	203:210	arg1	yield					177:181	Milk yield	172:181	Milk yield	172:181	Milk yield and composition are modified by level and chemical characteristics of dietary energy and protein.
34955268	1	110	mod	modified	203:210	arg3	level					215:219	level	215:219	level	215:219	Milk yield and composition are modified by level and chemical characteristics of dietary energy and protein.
34955268	1	110	mod	modified	203:210	arg3	characteristics					234:248	chemical characteristics	225:248	chemical characteristics	225:248	Milk yield and composition are modified by level and chemical characteristics of dietary energy and protein.
34955268	1	110	mod	modified	203:210	arg1	composition					187:197	composition	187:197	composition	187:197	Milk yield and composition are modified by level and chemical characteristics of dietary energy and protein.
34955268	11	111	theme	LS-fed	1722:1727	arg1	cows					1729:1732	LS-fed cows	1722:1732	LS-fed cows	1722:1732	This response was associated with greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows.
34955268	0	112	from	status	79:84	arg1	cows					166:169	Holstein dairy cows	151:169	Holstein dairy cows	151:169	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	16	113	theme	somatotropin/insulin	2362:2381	arg1	ratio					2383:2387	A higher bovine somatotropin/insulin ratio	2346:2387	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS	2346:2425	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS could possibly have led to greater breakdown and, consequently, higher AA flux from peripheral tissues.
34955268	17	114	theme	LS-fed	2534:2539	arg1	cows					2541:2544	LS-fed cows	2534:2544	LS-fed cows	2534:2544	In LS-fed cows, higher mobilization of body fat and protein was confirmed by the greater body weight loss in both stages of lactation.
34955268	3	115	theme	fermentable	685:695	arg1	feed					697:700	rumen fermentable feed	679:700	rumen fermentable feed with either high (HS) or low starch (LS)	679:741	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	19	116	theme	higher	2996:3001	arg1	firmness					3008:3015	higher curd firmness	2996:3015	higher curd firmness	2996:3015	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	15	117	theme	relative	2202:2209	arg1	concentrations					2180:2193	plasma concentrations	2173:2193	plasma concentrations at 8 h relative to pre-feeding values (time zero)	2173:2243	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	4	118	theme	rumen-undegradable	811:828	arg1	protein					830:836	rumen-undegradable protein	811:836	rumen-undegradable protein (∼40% of crude protein)	811:860	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	16	119	theme	AA	2498:2499	arg1	flux					2501:2504	higher AA flux	2491:2504	higher AA flux from peripheral tissues	2491:2528	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS could possibly have led to greater breakdown and, consequently, higher AA flux from peripheral tissues.
34955268	12	120	theme	average	1751:1757	arg1	concentrations					1759:1772	average concentrations	1751:1772	average concentrations of all AA in blood	1751:1791	Except for His, average concentrations of all AA in blood were higher in late than early lactation.
34955268	4	121	dep	protein	830:836	arg1	%					842:842	∼40%	839:842	∼40% of crude protein	839:859	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	4	121	dep	protein	830:836	arg1	protein					853:859	crude protein	847:859	crude protein	847:859	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	11	122	theme	blood	1589:1593	arg1	concentrations					1595:1608	greater blood concentrations	1581:1608	greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows	1581:1732	This response was associated with greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows.
34955268	9	123	theme	Dry	1374:1376	arg1	intake					1385:1390	Dry matter intake	1374:1390	Dry matter intake within each stage of lactation	1374:1421	Dry matter intake within each stage of lactation was similar between groups.
34955268	3	124	theme	high	714:717	arg1	LS					739:740	LS	739:740	LS	739:740	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	3	124	theme	high	714:717	arg1	starch					731:736	either high (HS) or low starch	707:736	either high (HS) or low starch (LS)	707:741	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	6	125	from	start	1089:1093	arg1	h					1082:1082	0, 2, 4, 5, 6, 7, and 8 h	1058:1082	0, 2, 4, 5, 6, 7, and 8 h from start of infusion	1058:1105	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	10	126	theme	blood	1480:1484	arg1	glucose					1486:1492	lower blood glucose	1474:1492	lower blood glucose	1474:1492	Feeding LS resulted in lower blood glucose and greater ratio of bovine somatotropin to insulin.
34955268	19	127	theme	curd	2968:2971	arg1	rate					2981:2984	lower curd firming rate	2962:2984	lower curd firming rate	2962:2984	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	19	128	from	stages	2904:2909	arg1	similar					2873:2879	similar	2873:2879	similar	2873:2879	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	4	129	theme	dry	795:797	arg1	matter					799:804	15.5% dry matter	789:804	15.5% dry matter	789:804	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	4	129	theme	dry	795:797	arg1	protein					780:786	dietary crude protein	766:786	dietary crude protein (15.5% dry matter)	766:805	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	17	130	theme	lactation	2655:2663	arg1	stages					2645:2650	both stages	2640:2650	both stages of lactation	2640:2663	In LS-fed cows, higher mobilization of body fat and protein was confirmed by the greater body weight loss in both stages of lactation.
34955268	11	131	theme	fatty	1627:1631	arg1	acids					1633:1637	nonesterified fatty acids	1613:1637	nonesterified fatty acids	1613:1637	This response was associated with greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows.
34955268	11	132	theme	β-hydroxybutyrate	1643:1659	arg1	concentrations					1595:1608	greater blood concentrations	1581:1608	greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows	1581:1732	This response was associated with greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows.
34955268	4	133	theme	crude	847:851	arg1	protein					853:859	crude protein	847:859	crude protein	847:859	All diets had similar dietary crude protein (15.5% dry matter) and rumen-undegradable protein (∼40% of crude protein) content.
34955268	20	134	theme	mammary	3190:3196	arg1	gland					3198:3202	the mammary gland	3186:3202	the mammary gland	3186:3202	Overall, data indicated that rate of carbohydrate fermentability in the rumen can modify the availability of metabolites to the mammary gland and consequently modify milk protein coagulation.
34955268	17	135	from	loss	2632:2635	arg1	stages					2645:2650	both stages	2640:2650	both stages of lactation	2640:2663	In LS-fed cows, higher mobilization of body fat and protein was confirmed by the greater body weight loss in both stages of lactation.
34955268	18	136	theme	peripheral	2762:2771	arg1	tissues					2773:2779	peripheral tissues	2762:2779	peripheral tissues	2762:2779	Higher irreversible loss of [1-13C] Leu in early lactation suggested lower protein retention in peripheral tissues during early compared with late lactation.
34955268	14	137	theme	essential	1916:1924	arg1	AA					1926:1927	the essential AA	1912:1927	the essential AA (particularly branched-chain)	1912:1957	However, for most of the essential AA (particularly branched-chain), the HS diet led to a marked decrease in concentrations after the forage meal, resulting in significant differences between dietary groups in early lactation.
34955268	11	138	from	content	1711:1717	arg1	cows					1729:1732	LS-fed cows	1722:1732	LS-fed cows	1722:1732	This response was associated with greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows.
34955268	0	139	theme	blood	87:91	arg1	concentrations					104:117	blood amino acid concentrations	87:117	blood amino acid concentrations	87:117	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	8	140	dep	SAS	1294:1296	arg1	Inc.					1308:1311	Inc.	1308:1311	Inc.	1308:1311	Data were subjected to ANOVA using the MIXED procedure of SAS (SAS Institute Inc.), with time as repeated factor and cow as the random effect.
34955268	18	141	theme	early	2709:2713	arg1	lactation					2715:2723	early lactation	2709:2723	early lactation	2709:2723	Higher irreversible loss of [1-13C] Leu in early lactation suggested lower protein retention in peripheral tissues during early compared with late lactation.
34955268	19	142	theme	firming	2973:2979	arg1	rate					2981:2984	lower curd firming rate	2962:2984	lower curd firming rate	2962:2984	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	6	143	from	samples	1001:1007	arg1	d					938:938	d 28	938:941	d 28	938:941	On d 28, [1-13C] Leu was infused into one jugular vein with blood samples taken at 0, 2, 4, 6, and 8 h, and cows milked at 0, 2, 4, 5, 6, 7, and 8 h from start of infusion.
34955268	0	144	theme	acid	99:102	arg1	concentrations					104:117	blood amino acid concentrations	87:117	blood amino acid concentrations	87:117	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	3	145	dep	high	714:717	arg1	HS					720:721	HS	720:721	HS	720:721	Four multiparous dairy cows in early lactation and subsequently in late lactation were fed 2 diets for 28 d in a changeover design that provided, within the same stage of lactation, similar amounts of rumen fermentable feed with either high (HS) or low starch (LS).
34955268	20	146	theme	fermentability	3112:3125	arg1	rate					3091:3094	rate	3091:3094	rate of carbohydrate fermentability in the rumen	3091:3138	Overall, data indicated that rate of carbohydrate fermentability in the rumen can modify the availability of metabolites to the mammary gland and consequently modify milk protein coagulation.
34955268	20	147	theme	protein	3233:3239	arg1	coagulation					3241:3251	milk protein coagulation	3228:3251	milk protein coagulation	3228:3251	Overall, data indicated that rate of carbohydrate fermentability in the rumen can modify the availability of metabolites to the mammary gland and consequently modify milk protein coagulation.
34955268	18	148	theme	Leu	2702:2704	arg1	loss					2686:2689	Higher irreversible loss	2666:2689	Higher irreversible loss of [1-13C] Leu in early lactation	2666:2723	Higher irreversible loss of [1-13C] Leu in early lactation suggested lower protein retention in peripheral tissues during early compared with late lactation.
34955268	19	149	theme	late	3046:3049	arg1	lactation					3051:3059	late lactation	3046:3059	late lactation	3046:3059	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	15	150	theme	early-lactating	2121:2135	arg1	cows					2137:2140	early-lactating cows	2121:2140	early-lactating cows fed HS	2121:2147	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	18	151	theme	protein	2741:2747	arg1	retention					2749:2757	lower protein retention	2735:2757	lower protein retention in peripheral tissues	2735:2779	Higher irreversible loss of [1-13C] Leu in early lactation suggested lower protein retention in peripheral tissues during early compared with late lactation.
34955268	11	152	theme	fat	1707:1709	arg1	content					1711:1717	greater milk fat content	1694:1717	greater milk fat content in LS-fed cows	1694:1732	This response was associated with greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows.
34955268	18	153	from	loss	2686:2689	arg1	lactation					2715:2723	early lactation	2709:2723	early lactation	2709:2723	Higher irreversible loss of [1-13C] Leu in early lactation suggested lower protein retention in peripheral tissues during early compared with late lactation.
34955268	16	154	theme	higher	2491:2496	arg1	flux					2501:2504	higher AA flux	2491:2504	higher AA flux from peripheral tissues	2491:2528	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS could possibly have led to greater breakdown and, consequently, higher AA flux from peripheral tissues.
34955268	1	155	theme	energy	261:266	arg1	level					215:219	level	215:219	level	215:219	Milk yield and composition are modified by level and chemical characteristics of dietary energy and protein.
34955268	1	155	theme	energy	261:266	arg1	characteristics					234:248	chemical characteristics	225:248	chemical characteristics	225:248	Milk yield and composition are modified by level and chemical characteristics of dietary energy and protein.
34955268	20	156	theme	carbohydrate	3099:3110	arg1	fermentability					3112:3125	carbohydrate fermentability	3099:3125	carbohydrate fermentability in the rumen	3099:3138	Overall, data indicated that rate of carbohydrate fermentability in the rumen can modify the availability of metabolites to the mammary gland and consequently modify milk protein coagulation.
34955268	20	157	from	rate	3091:3094	arg1	rumen					3134:3138	the rumen	3130:3138	the rumen	3130:3138	Overall, data indicated that rate of carbohydrate fermentability in the rumen can modify the availability of metabolites to the mammary gland and consequently modify milk protein coagulation.
34955268	20	158	theme	metabolites	3171:3181	arg1	availability					3155:3166	the availability	3151:3166	the availability of metabolites to the mammary gland	3151:3202	Overall, data indicated that rate of carbohydrate fermentability in the rumen can modify the availability of metabolites to the mammary gland and consequently modify milk protein coagulation.
34955268	11	159	theme	greater	1581:1587	arg1	concentrations					1595:1608	greater blood concentrations	1581:1608	greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows	1581:1732	This response was associated with greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows.
34955268	1	160	theme	protein	272:278	arg1	level					215:219	level	215:219	level	215:219	Milk yield and composition are modified by level and chemical characteristics of dietary energy and protein.
34955268	1	160	theme	protein	272:278	arg1	characteristics					234:248	chemical characteristics	225:248	chemical characteristics	225:248	Milk yield and composition are modified by level and chemical characteristics of dietary energy and protein.
34955268	18	161	theme	Higher	2666:2671	arg1	loss					2686:2689	Higher irreversible loss	2666:2689	Higher irreversible loss of [1-13C] Leu in early lactation	2666:2723	Higher irreversible loss of [1-13C] Leu in early lactation suggested lower protein retention in peripheral tissues during early compared with late lactation.
34955268	2	162	theme	metabolites	444:454	arg1	availability					428:439	availability	428:439	availability of metabolites to the mammary gland	428:475	Those factors determine nutrient availability from a given diet, and once absorbed, they interact with the endocrine system and together determine availability of metabolites to the mammary gland.
34955268	17	163	theme	body	2620:2623	arg1	loss					2632:2635	the greater body weight loss	2608:2635	the greater body weight loss in both stages of lactation	2608:2663	In LS-fed cows, higher mobilization of body fat and protein was confirmed by the greater body weight loss in both stages of lactation.
34955268	0	164	theme	starch	41:46	arg1	content					48:54	dietary starch content	33:54	dietary starch content	33:54	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	7	165	theme	Leu	1217:1219	arg1	kinetics					1221:1228	Leu kinetics	1217:1228	Leu kinetics	1217:1228	Isotopic enrichments of plasma Leu, keto-isocaproic acid, and milk casein were determined for calculation of Leu kinetics.
34955268	8	166	theme	MIXED	1270:1274	arg1	procedure					1276:1284	the MIXED procedure	1266:1284	the MIXED procedure	1266:1284	Data were subjected to ANOVA using the MIXED procedure of SAS (SAS Institute Inc.), with time as repeated factor and cow as the random effect.
34955268	8	166	theme	MIXED	1270:1274	arg1	effect					1366:1371	the random effect	1355:1371	the random effect	1355:1371	Data were subjected to ANOVA using the MIXED procedure of SAS (SAS Institute Inc.), with time as repeated factor and cow as the random effect.
34955268	14	167	theme	early	2101:2105	arg1	lactation					2107:2115	early lactation	2101:2115	early lactation	2101:2115	However, for most of the essential AA (particularly branched-chain), the HS diet led to a marked decrease in concentrations after the forage meal, resulting in significant differences between dietary groups in early lactation.
34955268	12	168	theme	early	1818:1822	arg1	lactation					1824:1832	early lactation	1818:1832	early lactation	1818:1832	Except for His, average concentrations of all AA in blood were higher in late than early lactation.
34955268	18	169	theme	irreversible	2673:2684	arg1	loss					2686:2689	Higher irreversible loss	2666:2689	Higher irreversible loss of [1-13C] Leu in early lactation	2666:2723	Higher irreversible loss of [1-13C] Leu in early lactation suggested lower protein retention in peripheral tissues during early compared with late lactation.
34955268	11	170	theme	nonesterified	1613:1625	arg1	acids					1633:1637	nonesterified fatty acids	1613:1637	nonesterified fatty acids	1613:1637	This response was associated with greater blood concentrations of nonesterified fatty acids and β-hydroxybutyrate, which might have contributed to greater milk fat content in LS-fed cows.
34955268	0	171	from	yield	125:129	arg1	cows					166:169	Holstein dairy cows	151:169	Holstein dairy cows	151:169	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	10	172	theme	bovine	1515:1520	arg1	somatotropin					1522:1533	bovine somatotropin	1515:1533	bovine somatotropin	1515:1533	Feeding LS resulted in lower blood glucose and greater ratio of bovine somatotropin to insulin.
34955268	2	173	theme	nutrient	305:312	arg1	availability					314:325	nutrient availability	305:325	nutrient availability	305:325	Those factors determine nutrient availability from a given diet, and once absorbed, they interact with the endocrine system and together determine availability of metabolites to the mammary gland.
34955268	15	174	theme	plasma	2173:2178	arg1	concentrations					2180:2193	plasma concentrations	2173:2193	plasma concentrations at 8 h relative to pre-feeding values (time zero)	2173:2243	In early-lactating cows fed HS, a greater reduction in plasma concentrations at 8 h relative to pre-feeding values (time zero) was observed for Met, Lys, and His, resulting in decreases of 27.9%, 33.6%, and 38.5%, respectively.
34955268	19	175	theme	lactation	2914:2922	arg1	stages					2904:2909	both stages	2899:2909	both stages of lactation	2899:2922	Milk yield, protein output, and composition were similar between groups at both stages of lactation, whereas milk coagulation was faster (lower curd firming rate) and with higher curd firmness in response to feeding HS in late lactation.
34955268	14	176	dep	AA	1926:1927	arg1	branched-chain					1943:1956	branched-chain	1943:1956	branched-chain	1943:1956	However, for most of the essential AA (particularly branched-chain), the HS diet led to a marked decrease in concentrations after the forage meal, resulting in significant differences between dietary groups in early lactation.
34955268	0	177	from	concentrations	104:117	arg1	cows					166:169	Holstein dairy cows	151:169	Holstein dairy cows	151:169	Effect of stage of lactation and dietary starch content on endocrine-metabolic status, blood amino acid concentrations, milk yield, and composition in Holstein dairy cows.
34955268	16	178	from	ratio	2383:2387	arg1	lactation					2398:2406	early lactation	2392:2406	early lactation	2392:2406	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS could possibly have led to greater breakdown and, consequently, higher AA flux from peripheral tissues.
34955268	16	178	from	ratio	2383:2387	arg1	cows					2415:2418	cows	2415:2418	cows fed LS	2415:2425	A higher bovine somatotropin/insulin ratio in early lactation and in cows fed LS could possibly have led to greater breakdown and, consequently, higher AA flux from peripheral tissues.
34670204	1	0	theme	biodegradable	171:183	arg1	polymers					185:192	natural biodegradable polymers	163:192	natural biodegradable polymers commonly used in the regeneration of bone defects	163:242	Collagen and chitosan are two different kinds of natural biodegradable polymers commonly used in the regeneration of bone defects.
34670204	3	1	from	differentiation	570:584	arg1	BMSCs					637:641	BMSCs	637:641	BMSCs	637:641	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	3	1	from	differentiation	570:584	arg1	cells					630:634	bone mesenchymal stem cells	608:634	bone mesenchymal stem cells (BMSCs)	608:642	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	5	2	theme	I	947:947	arg1	andRunx2					977:984	andRunx2	977:984	andRunx2	977:984	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	2	theme	I	947:947	arg1	Osteopontin					959:969	Osteopontin	959:969	Osteopontin(Opn)	959:974	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	2	theme	I	947:947	arg1	collagen					949:956	the expression ofType I collagen	925:956	the expression ofType I collagen	925:956	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	2	theme	I	947:947	arg1	genes					1027:1031	important osteoblastic marker genes	997:1031	important osteoblastic marker genes implicated in the process of osteoblast differentiation	997:1087	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	1	3	theme	polymers	185:192	arg1	Collagen					114:121	Collagen	114:121	Collagen	114:121	Collagen and chitosan are two different kinds of natural biodegradable polymers commonly used in the regeneration of bone defects.
34670204	1	3	theme	polymers	185:192	arg1	kinds					154:158	two different kinds	140:158	two different kinds of natural biodegradable polymers commonly used in the regeneration of bone defects	140:242	Collagen and chitosan are two different kinds of natural biodegradable polymers commonly used in the regeneration of bone defects.
34670204	1	3	theme	polymers	185:192	arg1	chitosan					127:134	chitosan	127:134	chitosan	127:134	Collagen and chitosan are two different kinds of natural biodegradable polymers commonly used in the regeneration of bone defects.
34670204	5	4	theme	ofType	940:945	arg1	andRunx2					977:984	andRunx2	977:984	andRunx2	977:984	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	4	theme	ofType	940:945	arg1	Osteopontin					959:969	Osteopontin	959:969	Osteopontin(Opn)	959:974	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	4	theme	ofType	940:945	arg1	collagen					949:956	the expression ofType I collagen	925:956	the expression ofType I collagen	925:956	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	4	theme	ofType	940:945	arg1	genes					1027:1031	important osteoblastic marker genes	997:1031	important osteoblastic marker genes implicated in the process of osteoblast differentiation	997:1087	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	2	5	theme	favorable	291:299	arg1	filler					306:311	favorable bone filler	291:311	favorable bone filler	291:311	Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds.
34670204	3	6	theme	bone	608:611	arg1	BMSCs					637:641	BMSCs	637:641	BMSCs	637:641	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	3	6	theme	bone	608:611	arg1	cells					630:634	bone mesenchymal stem cells	608:634	bone mesenchymal stem cells (BMSCs)	608:642	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	3	7	dep	displayed	521:529	arg1	increased					545:553	increased	545:553	displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs)	521:642	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	4	8	theme	Runx2	762:766	arg1	pathway					768:774	extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway	700:774	extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway	700:774	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	4	8	theme	Runx2	762:766	arg1	pathway					812:818	the predominant signaling pathway	786:818	the predominant signaling pathway involved in osteoblast differentiation	786:857	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	4	9	theme	activated	752:760	arg1	pathway					768:774	extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway	700:774	extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway	700:774	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	4	9	theme	activated	752:760	arg1	pathway					812:818	the predominant signaling pathway	786:818	the predominant signaling pathway involved in osteoblast differentiation	786:857	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	3	10	from	proliferation	555:567	arg1	BMSCs					637:641	BMSCs	637:641	BMSCs	637:641	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	3	10	from	proliferation	555:567	arg1	cells					630:634	bone mesenchymal stem cells	608:634	bone mesenchymal stem cells (BMSCs)	608:642	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	5	11	theme	important	997:1005	arg1	collagen					949:956	the expression ofType I collagen	925:956	the expression ofType I collagen	925:956	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	11	theme	important	997:1005	arg1	genes					1027:1031	important osteoblastic marker genes	997:1031	important osteoblastic marker genes implicated in the process of osteoblast differentiation	997:1087	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	2	12	theme	factors	414:420	arg1	exchange					392:399	an exchange	389:399	an exchange of important factors between the cells and scaffolds	389:452	Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds.
34670204	4	13	theme	signaling	802:810	arg1	pathway					768:774	extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway	700:774	extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway	700:774	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	4	13	theme	signaling	802:810	arg1	pathway					812:818	the predominant signaling pathway	786:818	the predominant signaling pathway involved in osteoblast differentiation	786:857	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	6	14	theme	composite	1122:1130	arg1	scaffold					1132:1139	the composite scaffold	1118:1139	the composite scaffold	1118:1139	Therefore, we conclude that the composite scaffold can significantly promote the differentiation of BMSCs into osteoblasts by activating Erk1/2-Runx2 pathway.
34670204	2	15	theme	important	404:412	arg1	factors					414:420	important factors	404:420	important factors	404:420	Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds.
34670204	3	16	theme	mesenchymal	613:623	arg1	BMSCs					637:641	BMSCs	637:641	BMSCs	637:641	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	3	16	theme	mesenchymal	613:623	arg1	cells					630:634	bone mesenchymal stem cells	608:634	bone mesenchymal stem cells (BMSCs)	608:642	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	7	17	theme	potential	1325:1333	arg1	biomaterial					1335:1345	a potential biomaterial	1323:1345	a potential biomaterial in the bone regeneration	1323:1370	Our finding thereby implies that the C-C-MBG scaffold can possibly act as a potential biomaterial in the bone regeneration.
34670204	7	17	theme	potential	1325:1333	arg1	scaffold					1294:1301	the C-C-MBG scaffold	1282:1301	the C-C-MBG scaffold	1282:1301	Our finding thereby implies that the C-C-MBG scaffold can possibly act as a potential biomaterial in the bone regeneration.
34670204	4	18	theme	signal	715:720	arg1	kinase					732:737	extra-cellular signal regulated kinase 1/2	700:741	extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway	700:774	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	4	18	theme	signal	715:720	arg1	Erk1/2					744:749	Erk1/2	744:749	Erk1/2	744:749	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	7	19	from	biomaterial	1335:1345	arg1	regeneration					1359:1370	the bone regeneration	1350:1370	the bone regeneration	1350:1370	Our finding thereby implies that the C-C-MBG scaffold can possibly act as a potential biomaterial in the bone regeneration.
34670204	3	20	theme	stem	625:628	arg1	BMSCs					637:641	BMSCs	637:641	BMSCs	637:641	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	3	20	theme	stem	625:628	arg1	cells					630:634	bone mesenchymal stem cells	608:634	bone mesenchymal stem cells (BMSCs)	608:642	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	4	21	theme	extra-cellular	700:713	arg1	kinase					732:737	extra-cellular signal regulated kinase 1/2	700:741	extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway	700:774	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	4	21	theme	extra-cellular	700:713	arg1	Erk1/2					744:749	Erk1/2	744:749	Erk1/2	744:749	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	0	22	theme	functionalized	16:29	arg1	scaffolds					53:61	novel functionalized collagen-chitosan-MBG scaffolds	10:61	novel functionalized collagen-chitosan-MBG scaffolds	10:61	Design of novel functionalized collagen-chitosan-MBG scaffolds for enhancing osteoblast differentiation in BMSCs.
34670204	2	23	theme	filler	306:311	arg1	glass					266:270	Mesoporous bioactive glass	245:270	Mesoporous bioactive glass (MBG)	245:276	Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds.
34670204	2	23	theme	filler	306:311	arg1	type					283:286	a type	281:286	a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds	281:452	Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds.
34670204	3	24	theme	collagen-chitosan-MBG	474:494	arg1	scaffold					506:513	a collagen-chitosan-MBG (C-C-MBG) scaffold	472:513	a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs)	472:642	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	0	25	theme	novel	10:14	arg1	scaffolds					53:61	novel functionalized collagen-chitosan-MBG scaffolds	10:61	novel functionalized collagen-chitosan-MBG scaffolds	10:61	Design of novel functionalized collagen-chitosan-MBG scaffolds for enhancing osteoblast differentiation in BMSCs.
34670204	6	26	theme	Erk1/2-Runx2	1227:1238	arg1	pathway					1240:1246	Erk1/2-Runx2 pathway	1227:1246	Erk1/2-Runx2 pathway	1227:1246	Therefore, we conclude that the composite scaffold can significantly promote the differentiation of BMSCs into osteoblasts by activating Erk1/2-Runx2 pathway.
34670204	2	27	theme	bone	301:304	arg1	filler					306:311	favorable bone filler	291:311	favorable bone filler	291:311	Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds.
34670204	5	28	theme	expression	929:938	arg1	andRunx2					977:984	andRunx2	977:984	andRunx2	977:984	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	28	theme	expression	929:938	arg1	Osteopontin					959:969	Osteopontin	959:969	Osteopontin(Opn)	959:974	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	28	theme	expression	929:938	arg1	collagen					949:956	the expression ofType I collagen	925:956	the expression ofType I collagen	925:956	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	28	theme	expression	929:938	arg1	genes					1027:1031	important osteoblastic marker genes	997:1031	important osteoblastic marker genes implicated in the process of osteoblast differentiation	997:1087	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	0	29	theme	scaffolds	53:61	arg1	Design					0:5	Design	0:5	Design of novel functionalized collagen-chitosan-MBG scaffolds for enhancing osteoblast differentiation in BMSCs.	0:112	Design of novel functionalized collagen-chitosan-MBG scaffolds for enhancing osteoblast differentiation in BMSCs.
34670204	7	30	theme	bone	1354:1357	arg1	regeneration					1359:1370	the bone regeneration	1350:1370	the bone regeneration	1350:1370	Our finding thereby implies that the C-C-MBG scaffold can possibly act as a potential biomaterial in the bone regeneration.
34670204	1	31	theme	bone	231:234	arg1	defects					236:242	bone defects	231:242	bone defects	231:242	Collagen and chitosan are two different kinds of natural biodegradable polymers commonly used in the regeneration of bone defects.
34670204	0	32	theme	collagen-chitosan-MBG	31:51	arg1	scaffolds					53:61	novel functionalized collagen-chitosan-MBG scaffolds	10:61	novel functionalized collagen-chitosan-MBG scaffolds	10:61	Design of novel functionalized collagen-chitosan-MBG scaffolds for enhancing osteoblast differentiation in BMSCs.
34670204	0	33	from	differentiation	88:102	arg1	BMSCs					107:111	BMSCs	107:111	BMSCs	107:111	Design of novel functionalized collagen-chitosan-MBG scaffolds for enhancing osteoblast differentiation in BMSCs.
34670204	2	34	theme	bioactive	256:264	arg1	MBG					273:275	MBG	273:275	MBG	273:275	Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds.
34670204	2	34	theme	bioactive	256:264	arg1	glass					266:270	Mesoporous bioactive glass	245:270	Mesoporous bioactive glass (MBG)	245:276	Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds.
34670204	2	34	theme	bioactive	256:264	arg1	type					283:286	a type	281:286	a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds	281:452	Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds.
34670204	1	35	theme	defects	236:242	arg1	regeneration					215:226	the regeneration	211:226	the regeneration of bone defects	211:242	Collagen and chitosan are two different kinds of natural biodegradable polymers commonly used in the regeneration of bone defects.
34670204	2	36	theme	Mesoporous	245:254	arg1	MBG					273:275	MBG	273:275	MBG	273:275	Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds.
34670204	2	36	theme	Mesoporous	245:254	arg1	glass					266:270	Mesoporous bioactive glass	245:270	Mesoporous bioactive glass (MBG)	245:276	Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds.
34670204	2	36	theme	Mesoporous	245:254	arg1	type					283:286	a type	281:286	a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds	281:452	Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds.
34670204	2	37	theme	enlarged	349:356	arg1	microenvironment					358:373	an enlarged microenvironment	346:373	an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds	346:452	Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds.
34670204	5	38	theme	differentiation	1073:1087	arg1	process					1051:1057	the process	1047:1057	the process of osteoblast differentiation	1047:1087	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	39	theme	osteoblast	1062:1071	arg1	differentiation					1073:1087	osteoblast differentiation	1062:1087	osteoblast differentiation	1062:1087	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	40	theme	marker	1020:1025	arg1	collagen					949:956	the expression ofType I collagen	925:956	the expression ofType I collagen	925:956	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	40	theme	marker	1020:1025	arg1	genes					1027:1031	important osteoblastic marker genes	997:1031	important osteoblastic marker genes implicated in the process of osteoblast differentiation	997:1087	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	1	41	theme	different	144:152	arg1	Collagen					114:121	Collagen	114:121	Collagen	114:121	Collagen and chitosan are two different kinds of natural biodegradable polymers commonly used in the regeneration of bone defects.
34670204	1	41	theme	different	144:152	arg1	kinds					154:158	two different kinds	140:158	two different kinds of natural biodegradable polymers commonly used in the regeneration of bone defects	140:242	Collagen and chitosan are two different kinds of natural biodegradable polymers commonly used in the regeneration of bone defects.
34670204	1	41	theme	different	144:152	arg1	chitosan					127:134	chitosan	127:134	chitosan	127:134	Collagen and chitosan are two different kinds of natural biodegradable polymers commonly used in the regeneration of bone defects.
34670204	5	42	theme	osteoblastic	1007:1018	arg1	collagen					949:956	the expression ofType I collagen	925:956	the expression ofType I collagen	925:956	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	5	42	theme	osteoblastic	1007:1018	arg1	genes					1027:1031	important osteoblastic marker genes	997:1031	important osteoblastic marker genes implicated in the process of osteoblast differentiation	997:1087	Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation.
34670204	4	43	theme	predominant	790:800	arg1	pathway					768:774	extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway	700:774	extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway	700:774	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	4	43	theme	predominant	790:800	arg1	pathway					812:818	the predominant signaling pathway	786:818	the predominant signaling pathway involved in osteoblast differentiation	786:857	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	4	44	theme	regulated	722:730	arg1	kinase					732:737	extra-cellular signal regulated kinase 1/2	700:741	extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway	700:774	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	4	44	theme	regulated	722:730	arg1	Erk1/2					744:749	Erk1/2	744:749	Erk1/2	744:749	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	3	45	theme	C-C-MBG	497:503	arg1	scaffold					506:513	a collagen-chitosan-MBG (C-C-MBG) scaffold	472:513	a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs)	472:642	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	7	46	theme	C-C-MBG	1286:1292	arg1	biomaterial					1335:1345	a potential biomaterial	1323:1345	a potential biomaterial in the bone regeneration	1323:1370	Our finding thereby implies that the C-C-MBG scaffold can possibly act as a potential biomaterial in the bone regeneration.
34670204	7	46	theme	C-C-MBG	1286:1292	arg1	scaffold					1294:1301	the C-C-MBG scaffold	1282:1301	the C-C-MBG scaffold	1282:1301	Our finding thereby implies that the C-C-MBG scaffold can possibly act as a potential biomaterial in the bone regeneration.
34670204	3	47	from	mineralization	590:603	arg1	BMSCs					637:641	BMSCs	637:641	BMSCs	637:641	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	3	47	from	mineralization	590:603	arg1	cells					630:634	bone mesenchymal stem cells	608:634	bone mesenchymal stem cells (BMSCs)	608:642	Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs).
34670204	4	48	theme	kinase	732:737	arg1	pathway					768:774	extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway	700:774	extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway	700:774	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	4	48	theme	kinase	732:737	arg1	pathway					812:818	the predominant signaling pathway	786:818	the predominant signaling pathway involved in osteoblast differentiation	786:857	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	0	49	theme	osteoblast	77:86	arg1	differentiation					88:102	osteoblast differentiation	77:102	osteoblast differentiation in BMSCs	77:111	Design of novel functionalized collagen-chitosan-MBG scaffolds for enhancing osteoblast differentiation in BMSCs.
34670204	6	50	theme	BMSCs	1190:1194	arg1	differentiation					1171:1185	the differentiation	1167:1185	the differentiation of BMSCs into osteoblasts	1167:1211	Therefore, we conclude that the composite scaffold can significantly promote the differentiation of BMSCs into osteoblasts by activating Erk1/2-Runx2 pathway.
34670204	4	51	theme	osteoblast	832:841	arg1	differentiation					843:857	osteoblast differentiation	832:857	osteoblast differentiation	832:857	Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation.
34670204	1	52	theme	natural	163:169	arg1	polymers					185:192	natural biodegradable polymers	163:192	natural biodegradable polymers commonly used in the regeneration of bone defects	163:242	Collagen and chitosan are two different kinds of natural biodegradable polymers commonly used in the regeneration of bone defects.
32076624	6	0	theme	different	918:926	arg1	norcantharidin					939:952	norcantharidin	939:952	norcantharidin	939:952	However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts.
32076624	6	0	theme	different	918:926	arg1	amounts					928:934	different amounts	918:934	different amounts of norcantharidin	918:952	However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts.
32076624	1	1	from	defects	212:218	arg1	tumors					223:228	tumors	223:228	tumors	223:228	Hydroxyapatite can deliver drugs, and its composite material is capable of repairing bone defects in tumors.
32076624	6	2	theme	inhibitory	999:1008	arg1	effects					1010:1016	different inhibitory effects	989:1016	different inhibitory effects on osteosarcoma	989:1032	However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts.
32076624	7	3	theme	antitumor	1133:1141	arg1	performance					1143:1153	the antitumor performance	1129:1153	the antitumor performance of the composite	1129:1170	And, with the increase of the content of norcantharidin, the antitumor performance of the composite has been enhanced.
32076624	6	4	from	effects	1048:1054	arg1	osteosarcoma					1021:1032	osteosarcoma	1021:1032	osteosarcoma	1021:1032	However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts.
32076624	3	5	contain	containing	367:376	arg2	compounds					392:400	drug delivery compounds	378:400	drug delivery compounds	378:400	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
32076624	3	5	contain	containing	367:376	arg1	Composites					356:365	Composites	356:365	Composites containing drug delivery compounds	356:400	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
32076624	4	6	theme	hydroxyapatite	622:635	arg1	nano-SHAP					652:660	nano-SHAP	652:660	nano-SHAP	652:660	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	4	6	theme	hydroxyapatite	622:635	arg1	nanoparticles					637:649	hydroxyapatite nanoparticles	622:649	hydroxyapatite nanoparticles (nano-SHAP)	622:661	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	2	7	theme	growth	311:316	arg1	inhibition					318:327	tumor growth inhibition	305:327	tumor growth inhibition	305:327	This study was conducted to evaluate the effect of composite materials on tumor growth inhibition and bone growth induction.
32076624	6	8	theme	different	989:997	arg1	effects					1010:1016	different inhibitory effects	989:1016	different inhibitory effects on osteosarcoma	989:1032	However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts.
32076624	3	9	theme	delivery	383:390	arg1	compounds					392:400	drug delivery compounds	378:400	drug delivery compounds	378:400	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
32076624	7	10	theme	content	1102:1108	arg1	increase					1086:1093	the increase	1082:1093	the increase of the content of norcantharidin	1082:1126	And, with the increase of the content of norcantharidin, the antitumor performance of the composite has been enhanced.
32076624	8	11	theme	drug	1253:1256	arg1	system					1217:1222	the nano-SHAP system	1203:1222	the nano-SHAP system developed in this study	1203:1246	In summary, the nano-SHAP system developed in this study is a drug delivery material that can inhibit the growth of tumors and induce the proliferation of osteoblasts.
32076624	8	11	theme	drug	1253:1256	arg1	material					1267:1274	a drug delivery material	1251:1274	a drug delivery material that can inhibit the growth of tumors and induce the proliferation of osteoblasts	1251:1356	In summary, the nano-SHAP system developed in this study is a drug delivery material that can inhibit the growth of tumors and induce the proliferation of osteoblasts.
32076624	2	12	theme	tumor	305:309	arg1	inhibition					318:327	tumor growth inhibition	305:327	tumor growth inhibition	305:327	This study was conducted to evaluate the effect of composite materials on tumor growth inhibition and bone growth induction.
32076624	5	13	theme	normal	865:870	arg1	lines					877:881	normal cell lines	865:881	normal cell lines	865:881	The use of nano-SHAP alone did not affect the proliferation of normal cell lines.
32076624	1	14	theme	bone	207:210	arg1	defects					212:218	bone defects	207:218	bone defects in tumors	207:228	Hydroxyapatite can deliver drugs, and its composite material is capable of repairing bone defects in tumors.
32076624	6	15	theme	different	1038:1046	arg1	effects					1048:1054	different effects	1038:1054	different effects	1038:1054	However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts.
32076624	4	16	theme	osteosarcoma	686:697	arg1	MG-63					710:714	MG-63	710:714	MG-63	710:714	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	4	16	theme	osteosarcoma	686:697	arg1	line					704:707	an osteosarcoma cell line	683:707	an osteosarcoma cell line (MG-63)	683:715	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	3	17	theme	scanning	482:489	arg1	microscopy					500:509	scanning electron microscopy	482:509	scanning electron microscopy (SEM)	482:515	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
32076624	3	17	theme	scanning	482:489	arg1	SEM					512:514	SEM	512:514	SEM	512:514	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
32076624	0	18	theme	Strontium/Chitosan/Hydroxyapatite/Norcantharidin	0:47	arg1	Composite					49:57	Strontium/Chitosan/Hydroxyapatite/Norcantharidin Composite	0:57	Strontium/Chitosan/Hydroxyapatite/Norcantharidin Composite That	0:62	Strontium/Chitosan/Hydroxyapatite/Norcantharidin Composite That Inhibits Osteosarcoma and Promotes Osteogenesis In Vitro.
32076624	6	19	from	effects	1010:1016	arg1	osteosarcoma					1021:1032	osteosarcoma	1021:1032	osteosarcoma	1021:1032	However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts.
32076624	2	20	theme	growth	338:343	arg1	induction					345:353	bone growth induction	333:353	bone growth induction	333:353	This study was conducted to evaluate the effect of composite materials on tumor growth inhibition and bone growth induction.
32076624	3	21	theme	electron	491:498	arg1	microscopy					500:509	scanning electron microscopy	482:509	scanning electron microscopy (SEM)	482:515	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
32076624	3	21	theme	electron	491:498	arg1	SEM					512:514	SEM	512:514	SEM	512:514	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
32076624	5	22	theme	nano-SHAP	813:821	arg1	use					806:808	The use	802:808	The use of nano-SHAP	802:821	The use of nano-SHAP alone did not affect the proliferation of normal cell lines.
32076624	2	23	theme	bone	333:336	arg1	induction					345:353	bone growth induction	333:353	bone growth induction	333:353	This study was conducted to evaluate the effect of composite materials on tumor growth inhibition and bone growth induction.
32076624	2	24	from	effect	272:277	arg1	inhibition					318:327	tumor growth inhibition	305:327	tumor growth inhibition	305:327	This study was conducted to evaluate the effect of composite materials on tumor growth inhibition and bone growth induction.
32076624	2	24	from	effect	272:277	arg1	induction					345:353	bone growth induction	333:353	bone growth induction	333:353	This study was conducted to evaluate the effect of composite materials on tumor growth inhibition and bone growth induction.
32076624	8	25	theme	delivery	1258:1265	arg1	system					1217:1222	the nano-SHAP system	1203:1222	the nano-SHAP system developed in this study	1203:1246	In summary, the nano-SHAP system developed in this study is a drug delivery material that can inhibit the growth of tumors and induce the proliferation of osteoblasts.
32076624	8	25	theme	delivery	1258:1265	arg1	material					1267:1274	a drug delivery material	1251:1274	a drug delivery material that can inhibit the growth of tumors and induce the proliferation of osteoblasts	1251:1356	In summary, the nano-SHAP system developed in this study is a drug delivery material that can inhibit the growth of tumors and induce the proliferation of osteoblasts.
32076624	8	26	theme	osteoblasts	1346:1356	arg1	proliferation					1329:1341	the proliferation	1325:1341	the proliferation of osteoblasts	1325:1356	In summary, the nano-SHAP system developed in this study is a drug delivery material that can inhibit the growth of tumors and induce the proliferation of osteoblasts.
32076624	3	27	theme	X-ray	518:522	arg1	XRD					537:539	XRD	537:539	XRD	537:539	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
32076624	3	27	theme	X-ray	518:522	arg1	diffraction					524:534	X-ray diffraction	518:534	X-ray diffraction (XRD)	518:540	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
32076624	6	28	theme	composite	961:969	arg1	materials					971:979	the composite materials	957:979	the composite materials	957:979	However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts.
32076624	8	29	theme	tumors	1307:1312	arg1	growth					1297:1302	the growth	1293:1302	the growth of tumors	1293:1312	In summary, the nano-SHAP system developed in this study is a drug delivery material that can inhibit the growth of tumors and induce the proliferation of osteoblasts.
32076624	4	30	theme	line	704:707	arg1	proliferation					666:678	proliferation	666:678	proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1)	666:754	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	4	31	theme	cell	699:702	arg1	MG-63					710:714	MG-63	710:714	MG-63	710:714	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	4	31	theme	cell	699:702	arg1	line					704:707	an osteosarcoma cell line	683:707	an osteosarcoma cell line (MG-63)	683:715	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	7	32	theme	composite	1162:1170	arg1	performance					1143:1153	the antitumor performance	1129:1153	the antitumor performance of the composite	1129:1170	And, with the increase of the content of norcantharidin, the antitumor performance of the composite has been enhanced.
32076624	5	33	theme	lines	877:881	arg1	proliferation					848:860	the proliferation	844:860	the proliferation of normal cell lines	844:881	The use of nano-SHAP alone did not affect the proliferation of normal cell lines.
32076624	8	34	theme	nano-SHAP	1207:1215	arg1	system					1217:1222	the nano-SHAP system	1203:1222	the nano-SHAP system developed in this study	1203:1246	In summary, the nano-SHAP system developed in this study is a drug delivery material that can inhibit the growth of tumors and induce the proliferation of osteoblasts.
32076624	8	34	theme	nano-SHAP	1207:1215	arg1	material					1267:1274	a drug delivery material	1251:1274	a drug delivery material that can inhibit the growth of tumors and induce the proliferation of osteoblasts	1251:1356	In summary, the nano-SHAP system developed in this study is a drug delivery material that can inhibit the growth of tumors and induce the proliferation of osteoblasts.
32076624	4	35	theme	cell	735:738	arg1	MC3T3-E1					746:753	MC3T3-E1	746:753	MC3T3-E1	746:753	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	4	35	theme	cell	735:738	arg1	line					740:743	an osteoblast cell line	721:743	an osteoblast cell line (MC3T3-E1)	721:754	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	6	36	theme	norcantharidin	939:952	arg1	norcantharidin					939:952	norcantharidin	939:952	norcantharidin	939:952	However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts.
32076624	6	36	theme	norcantharidin	939:952	arg1	amounts					928:934	different amounts	918:934	different amounts of norcantharidin	918:952	However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts.
32076624	6	37	contain	had	985:987	arg2	effects					1048:1054	different effects	1038:1054	different effects	1038:1054	However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts.
32076624	6	37	contain	had	985:987	arg1	nanoparticles					893:905	nanoparticles	893:905	nanoparticles	893:905	However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts.
32076624	6	37	contain	had	985:987	arg2	effects					1010:1016	different inhibitory effects	989:1016	different inhibitory effects on osteosarcoma	989:1032	However, nanoparticles containing different amounts of norcantharidin in the composite materials and had different inhibitory effects on osteosarcoma and different effects on osteoblasts.
32076624	4	38	theme	osteoblast	724:733	arg1	MC3T3-E1					746:753	MC3T3-E1	746:753	MC3T3-E1	746:753	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	4	38	theme	osteoblast	724:733	arg1	line					740:743	an osteoblast cell line	721:743	an osteoblast cell line (MC3T3-E1)	721:754	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	2	39	theme	materials	292:300	arg1	effect					272:277	the effect	268:277	the effect of composite materials on tumor growth inhibition and bone growth induction	268:353	This study was conducted to evaluate the effect of composite materials on tumor growth inhibition and bone growth induction.
32076624	1	40	theme	composite	164:172	arg1	material					174:181	its composite material	160:181	its composite material	160:181	Hydroxyapatite can deliver drugs, and its composite material is capable of repairing bone defects in tumors.
32076624	5	41	theme	cell	872:875	arg1	lines					877:881	normal cell lines	865:881	normal cell lines	865:881	The use of nano-SHAP alone did not affect the proliferation of normal cell lines.
32076624	4	42	from	effect	612:617	arg1	proliferation					666:678	proliferation	666:678	proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1)	666:754	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	2	43	theme	composite	282:290	arg1	materials					292:300	composite materials	282:300	composite materials	282:300	This study was conducted to evaluate the effect of composite materials on tumor growth inhibition and bone growth induction.
32076624	7	44	theme	norcantharidin	1113:1126	arg1	content					1102:1108	the content	1098:1108	the content of norcantharidin	1098:1126	And, with the increase of the content of norcantharidin, the antitumor performance of the composite has been enhanced.
32076624	4	45	theme	line	740:743	arg1	proliferation					666:678	proliferation	666:678	proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1)	666:754	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	4	46	theme	nanoparticles	637:649	arg1	effect					612:617	the effect	608:617	the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1)	608:754	In addition, the effect of hydroxyapatite nanoparticles (nano-SHAP) on proliferation of an osteosarcoma cell line (MG-63) and an osteoblast cell line (MC3T3-E1) was evaluated, and its mechanism was studied.
32076624	0	47	dep	Composite	49:57	arg1	That					59:62	That	59:62	That	59:62	Strontium/Chitosan/Hydroxyapatite/Norcantharidin Composite That Inhibits Osteosarcoma and Promotes Osteogenesis In Vitro.
32076624	8	48	from	material	1267:1274	arg1	summary					1194:1200	summary	1194:1200	summary	1194:1200	In summary, the nano-SHAP system developed in this study is a drug delivery material that can inhibit the growth of tumors and induce the proliferation of osteoblasts.
32076624	3	49	theme	Fourier-transform	547:563	arg1	FTIR					588:591	FTIR	588:591	FTIR	588:591	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
32076624	3	49	theme	Fourier-transform	547:563	arg1	spectroscopy					574:585	Fourier-transform infrared spectroscopy	547:585	Fourier-transform infrared spectroscopy (FTIR)	547:592	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
32076624	3	50	theme	drug	378:381	arg1	compounds					392:400	drug delivery compounds	378:400	drug delivery compounds	378:400	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
32076624	3	51	theme	infrared	565:572	arg1	FTIR					588:591	FTIR	588:591	FTIR	588:591	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
32076624	3	51	theme	infrared	565:572	arg1	spectroscopy					574:585	Fourier-transform infrared spectroscopy	547:585	Fourier-transform infrared spectroscopy (FTIR)	547:592	Composites containing drug delivery compounds were synthesized by coprecipitation and freeze-drying and then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR).
34291914	8	0	theme	Gram-positive	1202:1214	arg1	bacteria					1216:1223	Gram-positive bacteria	1202:1223	Gram-positive bacteria	1202:1223	We show that the assay is facile and versatile as demonstrated by its compatibility with sacculi from Gram-positive bacteria, Gram-negative bacteria, and mycobacteria.
34291914	8	1	from	mycobacteria	1254:1265	arg1	sacculi					1189:1195	sacculi	1189:1195	sacculi from Gram-positive bacteria, Gram-negative bacteria, and mycobacteria	1189:1265	We show that the assay is facile and versatile as demonstrated by its compatibility with sacculi from Gram-positive bacteria, Gram-negative bacteria, and mycobacteria.
34291914	7	2	theme	novel	940:944	arg1	platform					952:959	a novel assay platform	938:959	a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis	938:1097	We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis.
34291914	7	2	theme	novel	940:944	arg1	compatible					1043:1052	compatible	1043:1052	compatible	1043:1052	We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis.
34291914	7	2	theme	novel	940:944	arg1	SaccuFlow					962:970	SaccuFlow	962:970	SaccuFlow	962:970	We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis.
34291914	0	3	theme	Wall	77:80	arg1	Interactions					82:93	Bacterial Cell Wall Interactions	62:93	Bacterial Cell Wall Interactions	62:93	SaccuFlow: A High-Throughput Analysis Platform to Investigate Bacterial Cell Wall Interactions.
34291914	9	4	theme	sortase	1342:1348	arg1	A					1350:1350	sortase A	1342:1350	sortase A from Staphylococcus aureus	1342:1377	Finally, we highlight the utility of this assay to assess the activity of sortase A from Staphylococcus aureus against potential antivirulence agents.
34291914	6	5	theme	qualitative	900:910	arg1	effort					912:917	qualitative effort	900:917	qualitative effort	900:917	Evaluation of molecules or proteins that interact with peptidoglycan can be a complicated and, typically, qualitative effort.
34291914	4	6	dep	biosynthesis	477:488	arg1	The					473:475	The	473:475	The	473:475	The biosynthesis and remodeling of peptidoglycan must be tightly regulated by cells because disruption to this biomacromolecule is lethal.
34291914	3	7	theme	mesh-like	367:375	arg1	Peptidoglycan					348:360	Peptidoglycan	348:360	Peptidoglycan	348:360	Peptidoglycan is a mesh-like scaffold composed of cross-linked strands that can be heavily decorated with anchored proteins.
34291914	3	7	theme	mesh-like	367:375	arg1	scaffold					377:384	a mesh-like scaffold	365:384	a mesh-like scaffold composed of cross-linked strands that can be heavily decorated with anchored proteins	365:470	Peptidoglycan is a mesh-like scaffold composed of cross-linked strands that can be heavily decorated with anchored proteins.
34291914	9	8	theme	A	1350:1350	arg1	activity					1330:1337	the activity	1326:1337	the activity of sortase A from Staphylococcus aureus against potential antivirulence agents	1326:1416	Finally, we highlight the utility of this assay to assess the activity of sortase A from Staphylococcus aureus against potential antivirulence agents.
34291914	0	9	dep	Platform	38:45	arg1	Investigate					50:60	Investigate	50:60	to Investigate Bacterial Cell Wall Interactions	47:93	SaccuFlow: A High-Throughput Analysis Platform to Investigate Bacterial Cell Wall Interactions.
34291914	7	10	theme	native	992:997	arg1	structure					999:1007	the native structure	988:1007	the native structure of bacterial peptidoglycan	988:1034	We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis.
34291914	5	11	theme	innate	656:661	arg1	system					670:675	the human innate immune system	646:675	the human innate immune system in resisting colonization	646:701	This essentiality is exploited by the human innate immune system in resisting colonization and by a number of clinically relevant antibiotics that target peptidoglycan biosynthesis.
34291914	5	12	theme	human	650:654	arg1	system					670:675	the human innate immune system	646:675	the human innate immune system in resisting colonization	646:701	This essentiality is exploited by the human innate immune system in resisting colonization and by a number of clinically relevant antibiotics that target peptidoglycan biosynthesis.
34291914	1	13	theme	external	178:185	arg1	insults					187:193	external insults	178:193	external insults	178:193	Bacterial cell walls are formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure.
34291914	8	14	theme	Gram-negative	1226:1238	arg1	bacteria					1240:1247	Gram-negative bacteria	1226:1247	Gram-negative bacteria	1226:1247	We show that the assay is facile and versatile as demonstrated by its compatibility with sacculi from Gram-positive bacteria, Gram-negative bacteria, and mycobacteria.
34291914	5	15	theme	immune	663:668	arg1	system					670:675	the human innate immune system	646:675	the human innate immune system in resisting colonization	646:701	This essentiality is exploited by the human innate immune system in resisting colonization and by a number of clinically relevant antibiotics that target peptidoglycan biosynthesis.
34291914	3	16	theme	cross-linked	398:409	arg1	strands					411:417	cross-linked strands	398:417	cross-linked strands that can be heavily decorated with anchored proteins	398:470	Peptidoglycan is a mesh-like scaffold composed of cross-linked strands that can be heavily decorated with anchored proteins.
34291914	4	17	theme	peptidoglycan	508:520	arg1	remodeling					494:503	remodeling	494:503	remodeling	494:503	The biosynthesis and remodeling of peptidoglycan must be tightly regulated by cells because disruption to this biomacromolecule is lethal.
34291914	4	17	theme	peptidoglycan	508:520	arg1	biosynthesis					477:488	biosynthesis	477:488	biosynthesis	477:488	The biosynthesis and remodeling of peptidoglycan must be tightly regulated by cells because disruption to this biomacromolecule is lethal.
34291914	9	18	theme	potential	1387:1395	arg1	agents					1411:1416	potential antivirulence agents	1387:1416	potential antivirulence agents	1387:1416	Finally, we highlight the utility of this assay to assess the activity of sortase A from Staphylococcus aureus against potential antivirulence agents.
34291914	9	19	from	aureus	1372:1377	arg1	activity					1330:1337	the activity	1326:1337	the activity of sortase A from Staphylococcus aureus against potential antivirulence agents	1326:1416	Finally, we highlight the utility of this assay to assess the activity of sortase A from Staphylococcus aureus against potential antivirulence agents.
34291914	9	19	from	aureus	1372:1377	arg1	A					1350:1350	sortase A	1342:1350	sortase A from Staphylococcus aureus	1342:1377	Finally, we highlight the utility of this assay to assess the activity of sortase A from Staphylococcus aureus against potential antivirulence agents.
34291914	1	20	theme	Bacterial	96:104	arg1	barriers					132:139	formidable barriers	121:139	formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure	121:229	Bacterial cell walls are formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure.
34291914	1	20	theme	Bacterial	96:104	arg1	walls					111:115	Bacterial cell walls	96:115	Bacterial cell walls	96:115	Bacterial cell walls are formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure.
34291914	0	21	theme	High-Throughput	13:27	arg1	Platform					38:45	A High-Throughput Analysis Platform	11:45	SaccuFlow: A High-Throughput Analysis Platform to Investigate Bacterial Cell Wall Interactions.	0:94	SaccuFlow: A High-Throughput Analysis Platform to Investigate Bacterial Cell Wall Interactions.
34291914	9	22	theme	antivirulence	1397:1409	arg1	agents					1411:1416	potential antivirulence agents	1387:1416	potential antivirulence agents	1387:1416	Finally, we highlight the utility of this assay to assess the activity of sortase A from Staphylococcus aureus against potential antivirulence agents.
34291914	5	23	theme	relevant	733:740	arg1	antibiotics					742:752	clinically relevant antibiotics	722:752	clinically relevant antibiotics that target peptidoglycan biosynthesis	722:791	This essentiality is exploited by the human innate immune system in resisting colonization and by a number of clinically relevant antibiotics that target peptidoglycan biosynthesis.
34291914	1	24	theme	cell	106:109	arg1	barriers					132:139	formidable barriers	121:139	formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure	121:229	Bacterial cell walls are formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure.
34291914	1	24	theme	cell	106:109	arg1	walls					111:115	Bacterial cell walls	96:115	Bacterial cell walls	96:115	Bacterial cell walls are formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure.
34291914	1	25	theme	internal	206:213	arg1	pressure					222:229	internal turgor pressure	206:229	internal turgor pressure	206:229	Bacterial cell walls are formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure.
34291914	5	26	theme	antibiotics	742:752	arg1	number					712:717	a number	710:717	a number of clinically relevant antibiotics that target peptidoglycan biosynthesis	710:791	This essentiality is exploited by the human innate immune system in resisting colonization and by a number of clinically relevant antibiotics that target peptidoglycan biosynthesis.
34291914	2	27	theme	principal	309:317	arg1	component					319:327	the principal component	305:327	the principal component of all cell walls	305:345	While cell wall composition is variable across species, peptidoglycan is the principal component of all cell walls.
34291914	2	27	theme	principal	309:317	arg1	peptidoglycan					288:300	peptidoglycan	288:300	peptidoglycan	288:300	While cell wall composition is variable across species, peptidoglycan is the principal component of all cell walls.
34291914	1	28	theme	turgor	215:220	arg1	pressure					222:229	internal turgor pressure	206:229	internal turgor pressure	206:229	Bacterial cell walls are formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure.
34291914	0	29	theme	Analysis	29:36	arg1	Platform					38:45	A High-Throughput Analysis Platform	11:45	SaccuFlow: A High-Throughput Analysis Platform to Investigate Bacterial Cell Wall Interactions.	0:94	SaccuFlow: A High-Throughput Analysis Platform to Investigate Bacterial Cell Wall Interactions.
34291914	2	30	theme	wall	243:246	arg1	composition					248:258	cell wall composition	238:258	cell wall composition	238:258	While cell wall composition is variable across species, peptidoglycan is the principal component of all cell walls.
34291914	6	31	theme	proteins	821:828	arg1	Evaluation					794:803	Evaluation	794:803	Evaluation of molecules or proteins that interact with peptidoglycan	794:861	Evaluation of molecules or proteins that interact with peptidoglycan can be a complicated and, typically, qualitative effort.
34291914	6	31	theme	proteins	821:828	arg1	complicated					872:882	complicated	872:882	complicated	872:882	Evaluation of molecules or proteins that interact with peptidoglycan can be a complicated and, typically, qualitative effort.
34291914	9	32	from	activity	1330:1337	arg1	aureus					1372:1377	Staphylococcus aureus	1357:1377	Staphylococcus aureus	1357:1377	Finally, we highlight the utility of this assay to assess the activity of sortase A from Staphylococcus aureus against potential antivirulence agents.
34291914	5	33	theme	peptidoglycan	766:778	arg1	biosynthesis					780:791	peptidoglycan biosynthesis	766:791	peptidoglycan biosynthesis	766:791	This essentiality is exploited by the human innate immune system in resisting colonization and by a number of clinically relevant antibiotics that target peptidoglycan biosynthesis.
34291914	3	34	theme	anchored	454:461	arg1	proteins					463:470	anchored proteins	454:470	anchored proteins	454:470	Peptidoglycan is a mesh-like scaffold composed of cross-linked strands that can be heavily decorated with anchored proteins.
34291914	2	35	theme	cell	238:241	arg1	composition					248:258	cell wall composition	238:258	cell wall composition	238:258	While cell wall composition is variable across species, peptidoglycan is the principal component of all cell walls.
34291914	7	36	theme	cytometry	1080:1088	arg1	analysis					1090:1097	high-throughput flow cytometry analysis	1059:1097	high-throughput flow cytometry analysis	1059:1097	We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis.
34291914	9	37	theme	assay	1310:1314	arg1	utility					1294:1300	the utility	1290:1300	the utility of this assay to assess the activity of sortase A from Staphylococcus aureus against potential antivirulence agents	1290:1416	Finally, we highlight the utility of this assay to assess the activity of sortase A from Staphylococcus aureus against potential antivirulence agents.
34291914	8	38	from	bacteria	1240:1247	arg1	sacculi					1189:1195	sacculi	1189:1195	sacculi from Gram-positive bacteria, Gram-negative bacteria, and mycobacteria	1189:1265	We show that the assay is facile and versatile as demonstrated by its compatibility with sacculi from Gram-positive bacteria, Gram-negative bacteria, and mycobacteria.
34291914	6	39	theme	molecules	808:816	arg1	Evaluation					794:803	Evaluation	794:803	Evaluation of molecules or proteins that interact with peptidoglycan	794:861	Evaluation of molecules or proteins that interact with peptidoglycan can be a complicated and, typically, qualitative effort.
34291914	6	39	theme	molecules	808:816	arg1	complicated					872:882	complicated	872:882	complicated	872:882	Evaluation of molecules or proteins that interact with peptidoglycan can be a complicated and, typically, qualitative effort.
34291914	1	40	theme	formidable	121:130	arg1	barriers					132:139	formidable barriers	121:139	formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure	121:229	Bacterial cell walls are formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure.
34291914	1	40	theme	formidable	121:130	arg1	walls					111:115	Bacterial cell walls	96:115	Bacterial cell walls	96:115	Bacterial cell walls are formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure.
34291914	7	41	theme	bacterial	1012:1020	arg1	peptidoglycan					1022:1034	bacterial peptidoglycan	1012:1034	bacterial peptidoglycan	1012:1034	We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis.
34291914	2	42	theme	walls	341:345	arg1	component					319:327	the principal component	305:327	the principal component of all cell walls	305:345	While cell wall composition is variable across species, peptidoglycan is the principal component of all cell walls.
34291914	2	42	theme	walls	341:345	arg1	peptidoglycan					288:300	peptidoglycan	288:300	peptidoglycan	288:300	While cell wall composition is variable across species, peptidoglycan is the principal component of all cell walls.
34291914	7	43	theme	high-throughput	1059:1073	arg1	analysis					1090:1097	high-throughput flow cytometry analysis	1059:1097	high-throughput flow cytometry analysis	1059:1097	We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis.
34291914	7	44	theme	flow	1075:1078	arg1	analysis					1090:1097	high-throughput flow cytometry analysis	1059:1097	high-throughput flow cytometry analysis	1059:1097	We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis.
34291914	2	45	theme	cell	336:339	arg1	walls					341:345	all cell walls	332:345	all cell walls	332:345	While cell wall composition is variable across species, peptidoglycan is the principal component of all cell walls.
34291914	7	46	theme	assay	946:950	arg1	platform					952:959	a novel assay platform	938:959	a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis	938:1097	We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis.
34291914	7	46	theme	assay	946:950	arg1	compatible					1043:1052	compatible	1043:1052	compatible	1043:1052	We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis.
34291914	7	46	theme	assay	946:950	arg1	SaccuFlow					962:970	SaccuFlow	962:970	SaccuFlow	962:970	We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis.
34291914	0	47	theme	Cell	72:75	arg1	Interactions					82:93	Bacterial Cell Wall Interactions	62:93	Bacterial Cell Wall Interactions	62:93	SaccuFlow: A High-Throughput Analysis Platform to Investigate Bacterial Cell Wall Interactions.
34291914	8	48	from	bacteria	1216:1223	arg1	sacculi					1189:1195	sacculi	1189:1195	sacculi from Gram-positive bacteria, Gram-negative bacteria, and mycobacteria	1189:1265	We show that the assay is facile and versatile as demonstrated by its compatibility with sacculi from Gram-positive bacteria, Gram-negative bacteria, and mycobacteria.
34291914	3	49	link	cross-linked	398:409	arg1	strands					411:417	cross-linked strands	398:417	cross-linked strands that can be heavily decorated with anchored proteins	398:470	Peptidoglycan is a mesh-like scaffold composed of cross-linked strands that can be heavily decorated with anchored proteins.
34291914	0	50	theme	Bacterial	62:70	arg1	Interactions					82:93	Bacterial Cell Wall Interactions	62:93	Bacterial Cell Wall Interactions	62:93	SaccuFlow: A High-Throughput Analysis Platform to Investigate Bacterial Cell Wall Interactions.
34291914	0	51	dep	SaccuFlow	0:8	arg1	Platform					38:45	A High-Throughput Analysis Platform	11:45	SaccuFlow: A High-Throughput Analysis Platform to Investigate Bacterial Cell Wall Interactions.	0:94	SaccuFlow: A High-Throughput Analysis Platform to Investigate Bacterial Cell Wall Interactions.
34291914	7	52	theme	peptidoglycan	1022:1034	arg1	structure					999:1007	the native structure	988:1007	the native structure of bacterial peptidoglycan	988:1034	We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis.
34291914	1	53	theme	bacterial	154:162	arg1	cells					164:168	bacterial cells	154:168	bacterial cells	154:168	Bacterial cell walls are formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure.
34291914	8	54	with	compatibility	1170:1182	arg1	sacculi					1189:1195	sacculi	1189:1195	sacculi from Gram-positive bacteria, Gram-negative bacteria, and mycobacteria	1189:1265	We show that the assay is facile and versatile as demonstrated by its compatibility with sacculi from Gram-positive bacteria, Gram-negative bacteria, and mycobacteria.
34291914	7	55	with	compatible	1043:1052	arg1	analysis					1090:1097	high-throughput flow cytometry analysis	1059:1097	high-throughput flow cytometry analysis	1059:1097	We have developed a novel assay platform (SaccuFlow) that preserves the native structure of bacterial peptidoglycan and is compatible with high-throughput flow cytometry analysis.
33992373	9	0	theme	intestinal	1705:1714	arg1	peristalsis					1716:1726	intestinal peristalsis	1705:1726	intestinal peristalsis	1705:1726	From the perspective of the gut neuroendocrine system, both CHSD and lactulose could elevate neurotransmitters, such as motilin (MTL) and substance P (SP), which promote intestinal peristalsis and reduce the expression of vasoactive intestinal peptide, which inhibits intestinal peristalsis in the serum of STC rats.
33992373	8	1	theme	those	1491:1495	arg1	composition					1476:1486	the composition	1472:1486	the composition of those	1472:1495	Both CHSD and lactulose enhanced the level of short-chain fatty acids in the faeces of rats; however, the composition of those were different between the two drugs.
33992373	8	1	theme	those	1491:1495	arg1	different					1502:1510	different	1502:1510	different	1502:1510	Both CHSD and lactulose enhanced the level of short-chain fatty acids in the faeces of rats; however, the composition of those were different between the two drugs.
33992373	3	2	with	relationship	350:361	arg1	STC					368:370	STC	368:370	STC	368:370	The gut microbiota has a close relationship with STC.
33992373	10	3	theme	intestinal	1911:1920	arg1	peristalsis					1922:1932	intestinal peristalsis	1911:1932	intestinal peristalsis	1911:1932	CHSD could elevate gastrin expression, which also promoted intestinal peristalsis in serum, while lactulose did not have this effect.
33992373	2	4	theme	drugs	255:259	arg1	kinds					246:250	several kinds	238:250	several kinds of drugs for constipation	238:276	There are several kinds of drugs for constipation; however, each drug has its limitations.
33992373	7	5	theme	diphenoxylate-induced	1338:1358	arg1	rats					1364:1367	diphenoxylate-induced STC rats	1338:1367	diphenoxylate-induced STC rats	1338:1367	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	7	6	theme	Phascolarctobacterium	1283:1303	arg1	abundance					1261:1269	the relative abundance	1248:1269	the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats	1248:1367	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	6	7	link	linked	930:935	arg1	analyses					965:972	immunosorbent assay (ELISA) analyses	937:972	enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS)	923:1055	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	1	8	theme	transit	161:167	arg1	constipation					169:180	Slow transit constipation	156:180	Slow transit constipation (STC)	156:186	Slow transit constipation (STC) has become an epidemic medical problem.
33992373	1	8	theme	transit	161:167	arg1	STC					183:185	STC	183:185	STC	183:185	Slow transit constipation (STC) has become an epidemic medical problem.
33992373	7	9	theme	Akkernansia	1323:1333	arg1	abundance					1261:1269	the relative abundance	1248:1269	the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats	1248:1367	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	6	10	theme	gas	1012:1014	arg1	GC-MS					1050:1054	GC-MS	1050:1054	GC-MS	1050:1054	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	6	10	theme	gas	1012:1014	arg1	spectroscopy					1036:1047	gas chromatography-mass spectroscopy	1012:1047	gas chromatography-mass spectroscopy (GC-MS)	1012:1055	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	9	11	theme	intestinal	1768:1777	arg1	peptide					1779:1785	vasoactive intestinal peptide	1757:1785	vasoactive intestinal peptide	1757:1785	From the perspective of the gut neuroendocrine system, both CHSD and lactulose could elevate neurotransmitters, such as motilin (MTL) and substance P (SP), which promote intestinal peristalsis and reduce the expression of vasoactive intestinal peptide, which inhibits intestinal peristalsis in the serum of STC rats.
33992373	0	12	theme	slow	95:98	arg1	constipation					108:119	slow transit constipation	95:119	slow transit constipation induced by compound diphenoxylate	95:153	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
33992373	6	13	theme	CHSD	847:850	arg1	mechanisms					833:842	the mechanisms	829:842	the mechanisms of CHSD in rats with STC, induced by diphenoxylate	829:893	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	9	14	theme	gut	1563:1565	arg1	system					1582:1587	the gut neuroendocrine system	1559:1587	the gut neuroendocrine system	1559:1587	From the perspective of the gut neuroendocrine system, both CHSD and lactulose could elevate neurotransmitters, such as motilin (MTL) and substance P (SP), which promote intestinal peristalsis and reduce the expression of vasoactive intestinal peptide, which inhibits intestinal peristalsis in the serum of STC rats.
33992373	9	15	theme	system	1582:1587	arg1	perspective					1544:1554	the perspective	1540:1554	the perspective of the gut neuroendocrine system	1540:1587	From the perspective of the gut neuroendocrine system, both CHSD and lactulose could elevate neurotransmitters, such as motilin (MTL) and substance P (SP), which promote intestinal peristalsis and reduce the expression of vasoactive intestinal peptide, which inhibits intestinal peristalsis in the serum of STC rats.
33992373	5	16	theme	food	597:600	arg1	nigrum					672:677	semen sesami nigrum	659:677	semen sesami nigrum	659:677	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	16	theme	food	597:600	arg1	materials					613:621	medicine food homologous materials	588:621	medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed	588:692	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	16	theme	food	597:600	arg1	sweetalmond					646:656	sweetalmond	646:656	sweetalmond	646:656	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	16	theme	food	597:600	arg1	seed					689:692	hemp seed	684:692	hemp seed	684:692	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	16	theme	food	597:600	arg1	husk					640:643	psyllium husk	631:643	psyllium husk	631:643	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	7	17	from	abundance	1261:1269	arg1	rats					1364:1367	diphenoxylate-induced STC rats	1338:1367	diphenoxylate-induced STC rats	1338:1367	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	7	18	theme	Eubacterium	1306:1316	arg1	abundance					1261:1269	the relative abundance	1248:1269	the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats	1248:1367	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	0	19	from	microbiota	71:80	arg1	rats					85:88	rats	85:88	rats with slow transit constipation induced by compound diphenoxylate	85:153	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
33992373	7	20	theme	types	1103:1107	arg1	abundance					1085:1093	the relative abundance	1072:1093	the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium	1072:1220	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	0	21	from	effects	14:20	arg1	microbiota					71:80	gut microbiota	67:80	gut microbiota in rats with slow transit constipation induced by compound diphenoxylate	67:153	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
33992373	2	22	contain	has	298:300	arg1	drug					293:296	each drug	288:296	each drug	288:296	There are several kinds of drugs for constipation; however, each drug has its limitations.
33992373	2	22	contain	has	298:300	arg2	limitations					306:316	its limitations	302:316	its limitations	302:316	There are several kinds of drugs for constipation; however, each drug has its limitations.
33992373	4	23	theme	laxative	453:460	arg1	it					429:430	it	429:430	it	429:430	Lactulose is an effective drug for constipation because it is a kind of bulking laxative and microbioecologic, and it relieves the syndromes of STC.
33992373	4	23	theme	laxative	453:460	arg1	kind					437:440	a kind	435:440	a kind of bulking laxative and microbioecologic	435:481	Lactulose is an effective drug for constipation because it is a kind of bulking laxative and microbioecologic, and it relieves the syndromes of STC.
33992373	9	24	theme	rats	1846:1849	arg1	serum					1833:1837	the serum	1829:1837	the serum of STC rats	1829:1849	From the perspective of the gut neuroendocrine system, both CHSD and lactulose could elevate neurotransmitters, such as motilin (MTL) and substance P (SP), which promote intestinal peristalsis and reduce the expression of vasoactive intestinal peptide, which inhibits intestinal peristalsis in the serum of STC rats.
33992373	7	25	theme	relative	1076:1083	arg1	abundance					1085:1093	the relative abundance	1072:1093	the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium	1072:1220	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	5	26	theme	Chinese	540:546	arg1	Herb					548:551	the Chinese Herb	536:551	the Chinese Herb Solid Drink (CHSD)	536:570	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	11	27	theme	therapeutic	2046:2056	arg1	choice					2058:2063	an effective and safe therapeutic choice	2024:2063	an effective and safe therapeutic choice for STC	2024:2071	Our findings suggest that CHSD may be an effective and safe therapeutic choice for STC.
33992373	11	27	theme	therapeutic	2046:2056	arg1	CHSD					2012:2015	CHSD	2012:2015	CHSD	2012:2015	Our findings suggest that CHSD may be an effective and safe therapeutic choice for STC.
33992373	6	28	dep	linked	930:935	arg1	enzyme					923:928	enzyme	923:928	enzyme	923:928	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	5	29	theme	semen	659:663	arg1	nigrum					672:677	semen sesami nigrum	659:677	semen sesami nigrum	659:677	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	0	30	theme	Herb	33:36	arg1	effects					14:20	The different effects	0:20	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.	0:154	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
33992373	0	31	theme	lactulose	54:62	arg1	effects					14:20	The different effects	0:20	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.	0:154	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
33992373	5	32	theme	similar	701:707	arg1	effect					709:714	a similar effect	699:714	a similar effect	699:714	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	6	33	theme	immunosorbent	937:949	arg1	assay					951:955	immunosorbent assay	937:955	enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS)	923:1055	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	6	33	theme	immunosorbent	937:949	arg1	ELISA					958:962	ELISA	958:962	ELISA	958:962	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	8	34	theme	fatty	1428:1432	arg1	acids					1434:1438	short-chain fatty acids	1416:1438	short-chain fatty acids	1416:1438	Both CHSD and lactulose enhanced the level of short-chain fatty acids in the faeces of rats; however, the composition of those were different between the two drugs.
33992373	0	35	theme	Chinese	25:31	arg1	Herb					33:36	Chinese Herb	25:36	Chinese Herb	25:36	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
33992373	4	36	theme	microbioecologic	466:481	arg1	it					429:430	it	429:430	it	429:430	Lactulose is an effective drug for constipation because it is a kind of bulking laxative and microbioecologic, and it relieves the syndromes of STC.
33992373	4	36	theme	microbioecologic	466:481	arg1	kind					437:440	a kind	435:440	a kind of bulking laxative and microbioecologic	435:481	Lactulose is an effective drug for constipation because it is a kind of bulking laxative and microbioecologic, and it relieves the syndromes of STC.
33992373	6	37	dep	serum	980:984	arg1	amplicon					999:1006	amplicon	999:1006	amplicon	999:1006	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	0	38	theme	Solid	38:42	arg1	Drink					44:48	Solid Drink	38:48	Solid Drink	38:48	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
33992373	8	39	theme	rats	1457:1460	arg1	faeces					1447:1452	the faeces	1443:1452	the faeces of rats	1443:1460	Both CHSD and lactulose enhanced the level of short-chain fatty acids in the faeces of rats; however, the composition of those were different between the two drugs.
33992373	1	40	theme	medical	211:217	arg1	problem					219:225	an epidemic medical problem	199:225	an epidemic medical problem	199:225	Slow transit constipation (STC) has become an epidemic medical problem.
33992373	7	41	theme	STC	1360:1362	arg1	rats					1364:1367	diphenoxylate-induced STC rats	1338:1367	diphenoxylate-induced STC rats	1338:1367	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	7	42	theme	gut	1112:1114	arg1	microbiota					1116:1125	gut microbiota	1112:1125	gut microbiota	1112:1125	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	4	43	theme	STC	517:519	arg1	syndromes					504:512	the syndromes	500:512	the syndromes of STC	500:519	Lactulose is an effective drug for constipation because it is a kind of bulking laxative and microbioecologic, and it relieves the syndromes of STC.
33992373	10	44	contain	have	1968:1971	arg1	lactulose					1950:1958	lactulose	1950:1958	lactulose	1950:1958	CHSD could elevate gastrin expression, which also promoted intestinal peristalsis in serum, while lactulose did not have this effect.
33992373	10	44	contain	have	1968:1971	arg2	effect					1978:1983	this effect	1973:1983	this effect	1973:1983	CHSD could elevate gastrin expression, which also promoted intestinal peristalsis in serum, while lactulose did not have this effect.
33992373	5	45	theme	Solid	553:557	arg1	CHSD					566:569	CHSD	566:569	CHSD	566:569	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	45	theme	Solid	553:557	arg1	Drink					559:563	Solid Drink	553:563	the Chinese Herb Solid Drink (CHSD)	536:570	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	1	46	theme	Slow	156:159	arg1	constipation					169:180	Slow transit constipation	156:180	Slow transit constipation (STC)	156:186	Slow transit constipation (STC) has become an epidemic medical problem.
33992373	1	46	theme	Slow	156:159	arg1	STC					183:185	STC	183:185	STC	183:185	Slow transit constipation (STC) has become an epidemic medical problem.
33992373	3	47	contain	has	338:340	arg1	microbiota					327:336	The gut microbiota	319:336	The gut microbiota	319:336	The gut microbiota has a close relationship with STC.
33992373	3	47	contain	has	338:340	arg2	relationship					350:361	a close relationship	342:361	a close relationship with STC	342:370	The gut microbiota has a close relationship with STC.
33992373	6	48	with	rats	855:858	arg1	STC					865:867	STC	865:867	STC	865:867	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	0	49	with	rats	85:88	arg1	constipation					108:119	slow transit constipation	95:119	slow transit constipation induced by compound diphenoxylate	95:153	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
33992373	6	50	theme	chromatography-mass	1016:1034	arg1	GC-MS					1050:1054	GC-MS	1050:1054	GC-MS	1050:1054	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	6	50	theme	chromatography-mass	1016:1034	arg1	spectroscopy					1036:1047	gas chromatography-mass spectroscopy	1012:1047	gas chromatography-mass spectroscopy (GC-MS)	1012:1055	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	9	51	theme	vasoactive	1757:1766	arg1	peptide					1779:1785	vasoactive intestinal peptide	1757:1785	vasoactive intestinal peptide	1757:1785	From the perspective of the gut neuroendocrine system, both CHSD and lactulose could elevate neurotransmitters, such as motilin (MTL) and substance P (SP), which promote intestinal peristalsis and reduce the expression of vasoactive intestinal peptide, which inhibits intestinal peristalsis in the serum of STC rats.
33992373	0	52	theme	transit	100:106	arg1	constipation					108:119	slow transit constipation	95:119	slow transit constipation induced by compound diphenoxylate	95:153	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
33992373	9	53	theme	STC	1842:1844	arg1	rats					1846:1849	STC rats	1842:1849	STC rats	1842:1849	From the perspective of the gut neuroendocrine system, both CHSD and lactulose could elevate neurotransmitters, such as motilin (MTL) and substance P (SP), which promote intestinal peristalsis and reduce the expression of vasoactive intestinal peptide, which inhibits intestinal peristalsis in the serum of STC rats.
33992373	9	54	theme	peptide	1779:1785	arg1	expression					1743:1752	the expression	1739:1752	the expression of vasoactive intestinal peptide, which inhibits intestinal peristalsis in the serum of STC rats	1739:1849	From the perspective of the gut neuroendocrine system, both CHSD and lactulose could elevate neurotransmitters, such as motilin (MTL) and substance P (SP), which promote intestinal peristalsis and reduce the expression of vasoactive intestinal peptide, which inhibits intestinal peristalsis in the serum of STC rats.
33992373	5	55	theme	psyllium	631:638	arg1	husk					640:643	psyllium husk	631:643	psyllium husk	631:643	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	9	56	theme	neuroendocrine	1567:1580	arg1	system					1582:1587	the gut neuroendocrine system	1559:1587	the gut neuroendocrine system	1559:1587	From the perspective of the gut neuroendocrine system, both CHSD and lactulose could elevate neurotransmitters, such as motilin (MTL) and substance P (SP), which promote intestinal peristalsis and reduce the expression of vasoactive intestinal peptide, which inhibits intestinal peristalsis in the serum of STC rats.
33992373	7	57	theme	relative	1252:1259	arg1	abundance					1261:1269	the relative abundance	1248:1269	the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats	1248:1367	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	5	58	theme	medicine	588:595	arg1	nigrum					672:677	semen sesami nigrum	659:677	semen sesami nigrum	659:677	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	58	theme	medicine	588:595	arg1	materials					613:621	medicine food homologous materials	588:621	medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed	588:692	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	58	theme	medicine	588:595	arg1	sweetalmond					646:656	sweetalmond	646:656	sweetalmond	646:656	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	58	theme	medicine	588:595	arg1	seed					689:692	hemp seed	684:692	hemp seed	684:692	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	58	theme	medicine	588:595	arg1	husk					640:643	psyllium husk	631:643	psyllium husk	631:643	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	59	theme	gut	797:799	arg1	microbiota					801:810	the gut microbiota	793:810	the gut microbiota	793:810	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	60	contain	has	695:697	arg2	effect					709:714	a similar effect	699:714	a similar effect	699:714	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	60	contain	has	695:697	arg1	Herb					548:551	the Chinese Herb	536:551	the Chinese Herb Solid Drink (CHSD)	536:570	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	9	61	theme	intestinal	1803:1812	arg1	peristalsis					1814:1824	intestinal peristalsis	1803:1824	intestinal peristalsis	1803:1824	From the perspective of the gut neuroendocrine system, both CHSD and lactulose could elevate neurotransmitters, such as motilin (MTL) and substance P (SP), which promote intestinal peristalsis and reduce the expression of vasoactive intestinal peptide, which inhibits intestinal peristalsis in the serum of STC rats.
33992373	5	62	theme	homologous	602:611	arg1	nigrum					672:677	semen sesami nigrum	659:677	semen sesami nigrum	659:677	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	62	theme	homologous	602:611	arg1	materials					613:621	medicine food homologous materials	588:621	medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed	588:692	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	62	theme	homologous	602:611	arg1	sweetalmond					646:656	sweetalmond	646:656	sweetalmond	646:656	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	62	theme	homologous	602:611	arg1	seed					689:692	hemp seed	684:692	hemp seed	684:692	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	62	theme	homologous	602:611	arg1	husk					640:643	psyllium husk	631:643	psyllium husk	631:643	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	2	63	theme	several	238:244	arg1	kinds					246:250	several kinds	238:250	several kinds of drugs for constipation	238:276	There are several kinds of drugs for constipation; however, each drug has its limitations.
33992373	6	64	theme	constipation	900:911	arg1	index					913:917	constipation index	900:917	constipation index	900:917	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	4	65	theme	effective	389:397	arg1	Lactulose					373:381	Lactulose	373:381	Lactulose	373:381	Lactulose is an effective drug for constipation because it is a kind of bulking laxative and microbioecologic, and it relieves the syndromes of STC.
33992373	4	65	theme	effective	389:397	arg1	drug					399:402	an effective drug	386:402	an effective drug for constipation	386:419	Lactulose is an effective drug for constipation because it is a kind of bulking laxative and microbioecologic, and it relieves the syndromes of STC.
33992373	5	66	theme	sesami	665:670	arg1	nigrum					672:677	semen sesami nigrum	659:677	semen sesami nigrum	659:677	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	67	theme	different	772:780	arg1	effects					782:788	different effects	772:788	different effects	772:788	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	11	68	theme	safe	2041:2044	arg1	choice					2058:2063	an effective and safe therapeutic choice	2024:2063	an effective and safe therapeutic choice for STC	2024:2071	Our findings suggest that CHSD may be an effective and safe therapeutic choice for STC.
33992373	11	68	theme	safe	2041:2044	arg1	CHSD					2012:2015	CHSD	2012:2015	CHSD	2012:2015	Our findings suggest that CHSD may be an effective and safe therapeutic choice for STC.
33992373	4	69	theme	bulking	445:451	arg1	laxative					453:460	bulking laxative	445:460	bulking laxative	445:460	Lactulose is an effective drug for constipation because it is a kind of bulking laxative and microbioecologic, and it relieves the syndromes of STC.
33992373	0	70	theme	gut	67:69	arg1	microbiota					71:80	gut microbiota	67:80	gut microbiota in rats with slow transit constipation induced by compound diphenoxylate	67:153	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
33992373	11	71	theme	effective	2027:2035	arg1	choice					2058:2063	an effective and safe therapeutic choice	2024:2063	an effective and safe therapeutic choice for STC	2024:2071	Our findings suggest that CHSD may be an effective and safe therapeutic choice for STC.
33992373	11	71	theme	effective	2027:2035	arg1	CHSD					2012:2015	CHSD	2012:2015	CHSD	2012:2015	Our findings suggest that CHSD may be an effective and safe therapeutic choice for STC.
33992373	5	72	contain	has	768:770	arg1	it					765:766	it	765:766	it	765:766	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	72	contain	has	768:770	arg2	effects					782:788	different effects	772:788	different effects	772:788	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	10	73	theme	gastrin	1871:1877	arg1	expression					1879:1888	gastrin expression	1871:1888	gastrin expression	1871:1888	CHSD could elevate gastrin expression, which also promoted intestinal peristalsis in serum, while lactulose did not have this effect.
33992373	3	74	theme	gut	323:325	arg1	microbiota					327:336	The gut microbiota	319:336	The gut microbiota	319:336	The gut microbiota has a close relationship with STC.
33992373	8	75	theme	short-chain	1416:1426	arg1	acids					1434:1438	short-chain fatty acids	1416:1438	short-chain fatty acids	1416:1438	Both CHSD and lactulose enhanced the level of short-chain fatty acids in the faeces of rats; however, the composition of those were different between the two drugs.
33992373	0	76	theme	different	4:12	arg1	effects					14:20	The different effects	0:20	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.	0:154	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
33992373	6	77	theme	assay	951:955	arg1	analyses					965:972	immunosorbent assay (ELISA) analyses	937:972	enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS)	923:1055	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	3	78	theme	close	344:348	arg1	relationship					350:361	a close relationship	342:361	a close relationship with STC	342:370	The gut microbiota has a close relationship with STC.
33992373	8	79	theme	acids	1434:1438	arg1	level					1407:1411	the level	1403:1411	the level of short-chain fatty acids in the faeces of rats	1403:1460	Both CHSD and lactulose enhanced the level of short-chain fatty acids in the faeces of rats; however, the composition of those were different between the two drugs.
33992373	6	80	theme	linked	930:935	arg1	analyses					965:972	immunosorbent assay (ELISA) analyses	937:972	enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS)	923:1055	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	0	81	theme	compound	132:139	arg1	diphenoxylate					141:153	compound diphenoxylate	132:153	compound diphenoxylate	132:153	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
33992373	5	82	theme	hemp	684:687	arg1	seed					689:692	hemp seed	684:692	hemp seed	684:692	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	7	83	dep	Coprococcus	1170:1180	arg1	Roseburia					1159:1167	Roseburia	1159:1167	Roseburia	1159:1167	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	9	84	theme	substance	1673:1681	arg1	SP					1686:1687	SP	1686:1687	SP	1686:1687	From the perspective of the gut neuroendocrine system, both CHSD and lactulose could elevate neurotransmitters, such as motilin (MTL) and substance P (SP), which promote intestinal peristalsis and reduce the expression of vasoactive intestinal peptide, which inhibits intestinal peristalsis in the serum of STC rats.
33992373	9	84	theme	substance	1673:1681	arg1	P					1683:1683	substance P	1673:1683	substance P (SP)	1673:1688	From the perspective of the gut neuroendocrine system, both CHSD and lactulose could elevate neurotransmitters, such as motilin (MTL) and substance P (SP), which promote intestinal peristalsis and reduce the expression of vasoactive intestinal peptide, which inhibits intestinal peristalsis in the serum of STC rats.
33992373	8	85	from	level	1407:1411	arg1	faeces					1447:1452	the faeces	1443:1452	the faeces of rats	1443:1460	Both CHSD and lactulose enhanced the level of short-chain fatty acids in the faeces of rats; however, the composition of those were different between the two drugs.
33992373	0	86	dep	Herb	33:36	arg1	Drink					44:48	Solid Drink	38:48	Solid Drink	38:48	The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
33992373	6	87	theme	16S	990:992	arg1	rDNA					994:997	16S rDNA	990:997	16S rDNA	990:997	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	5	88	dep	Herb	548:551	arg1	CHSD					566:569	CHSD	566:569	CHSD	566:569	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	88	dep	Herb	548:551	arg1	Drink					559:563	Solid Drink	553:563	the Chinese Herb Solid Drink (CHSD)	536:570	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	89	contain	contains	579:586	arg2	materials					613:621	medicine food homologous materials	588:621	medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed	588:692	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	89	contain	contains	579:586	arg2	sweetalmond					646:656	sweetalmond	646:656	sweetalmond	646:656	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	89	contain	contains	579:586	arg2	seed					689:692	hemp seed	684:692	hemp seed	684:692	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	89	contain	contains	579:586	arg2	husk					640:643	psyllium husk	631:643	psyllium husk	631:643	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	89	contain	contains	579:586	arg2	nigrum					672:677	semen sesami nigrum	659:677	semen sesami nigrum	659:677	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	5	89	contain	contains	579:586	arg1	Herb					548:551	the Chinese Herb	536:551	the Chinese Herb Solid Drink (CHSD)	536:570	We found that the Chinese Herb Solid Drink (CHSD), which contains medicine food homologous materials such as psyllium husk, sweetalmond, semen sesami nigrum, and hemp seed, has a similar effect on relieving constipation as lactulose, although it has different effects on the gut microbiota.
33992373	6	90	from	mechanisms	833:842	arg1	rats					855:858	rats	855:858	rats with STC, induced by diphenoxylate	855:893	We investigated the mechanisms of CHSD in rats with STC, induced by diphenoxylate, via constipation index and enzyme linked immunosorbent assay (ELISA) analyses using serum and 16S rDNA amplicon and gas chromatography-mass spectroscopy (GC-MS).
33992373	1	91	theme	epidemic	202:209	arg1	problem					219:225	an epidemic medical problem	199:225	an epidemic medical problem	199:225	Slow transit constipation (STC) has become an epidemic medical problem.
33992373	7	92	theme	microbiota	1116:1125	arg1	Blautia					1136:1142	Blautia	1136:1142	Blautia	1136:1142	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	7	92	theme	microbiota	1116:1125	arg1	Lachnospira					1183:1193	Lachnospira	1183:1193	Lachnospira	1183:1193	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	7	92	theme	microbiota	1116:1125	arg1	Phascolarctobacterium					1200:1220	Phascolarctobacterium	1200:1220	Phascolarctobacterium	1200:1220	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	7	92	theme	microbiota	1116:1125	arg1	Coprococcus					1170:1180	Coprococcus	1170:1180	Coprococcus	1170:1180	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
33992373	7	92	theme	microbiota	1116:1125	arg1	types					1103:1107	some types	1098:1107	some types	1098:1107	CHSD enhanced the relative abundance of some types of gut microbiota, such as Blautia, Ruminococcus, Roseburia, Coprococcus, Lachnospira, and Phascolarctobacterium, while lactulose enhanced the relative abundance of Blautia, Phascolarctobacterium, Eubacterium, and Akkernansia in diphenoxylate-induced STC rats.
34165467	5	0	from	piglets	1024:1030	arg1	enriched					875:882	enriched	875:882	enriched	875:882	GOS intervention enriched fecal Alloprevotella and Ruminoclostridium_1 in gestational sows and vertically increased fecal Alloprevotella and Ruminococcaceae in their piglets (P < 0.05).
34165467	8	1	theme	neonatal	1506:1513	arg1	programming					1515:1525	This neonatal programming	1501:1525	This neonatal programming	1501:1525	This neonatal programming showed positive potential in promoting the intestinal barriers, immune defense, and growth performance of the piglets.
34165467	6	2	theme	maternal	1054:1061	arg1	intervention					1067:1078	maternal GOS intervention	1054:1078	maternal GOS intervention	1054:1078	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	2	3	from	development	335:345	arg1	offspring					354:362	the offspring	350:362	the offspring	350:362	However, the effects of nutritional programming by maternal GOS intervention on microbial colonization and intestinal development in the offspring remain unclear.
34165467	0	4	theme	intestinal	103:112	arg1	development					114:124	intestinal development	103:124	intestinal development	103:124	Maternal galactooligosaccharides supplementation programmed immune defense, microbial colonization and intestinal development in piglets.
34165467	9	5	from	GOS	1764:1766	arg1	nutrition					1789:1797	maternal-neonatal nutrition	1771:1797	maternal-neonatal nutrition	1771:1797	Our findings provide evidence for maternal nutritional programming in neonates and insights for future application of GOS in maternal-neonatal nutrition.
34165467	9	6	theme	GOS	1764:1766	arg1	application					1749:1759	future application	1742:1759	future application of GOS in maternal-neonatal nutrition	1742:1797	Our findings provide evidence for maternal nutritional programming in neonates and insights for future application of GOS in maternal-neonatal nutrition.
34165467	3	7	from	status	528:533	arg1	day					603:605	day 21	603:608	day 21	603:608	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	3	7	from	status	528:533	arg1	piglets					592:598	their piglets	586:598	their piglets	586:598	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	7	8	theme	maternal	1446:1453	arg1	microbes					1464:1471	maternal specific microbes	1446:1471	maternal specific microbes	1446:1471	In summary, GOS supplementation for sows during late gestation nutritionally programmed maternal specific microbes and IgA of their offspring.
34165467	7	9	theme	GOS	1370:1372	arg1	supplementation					1374:1388	GOS supplementation	1370:1388	GOS supplementation for sows during late gestation	1370:1419	In summary, GOS supplementation for sows during late gestation nutritionally programmed maternal specific microbes and IgA of their offspring.
34165467	4	10	theme	IgA	804:806	arg1	levels					808:813	the plasma IgA levels	793:813	the plasma IgA levels in both sows and their piglets (P < 0.05)	793:855	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	2	11	theme	intestinal	324:333	arg1	development					335:345	intestinal development	324:345	intestinal development	324:345	However, the effects of nutritional programming by maternal GOS intervention on microbial colonization and intestinal development in the offspring remain unclear.
34165467	5	12	theme	gestational	932:942	arg1	sows					944:947	gestational sows	932:947	gestational sows	932:947	GOS intervention enriched fecal Alloprevotella and Ruminoclostridium_1 in gestational sows and vertically increased fecal Alloprevotella and Ruminococcaceae in their piglets (P < 0.05).
34165467	4	13	theme	neonatal	755:762	arg1	stage					764:768	the neonatal stage	751:768	the neonatal stage (day 21)	751:777	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	4	13	theme	neonatal	755:762	arg1	day					771:773	day 21	771:776	day 21	771:776	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	9	14	theme	nutritional	1689:1699	arg1	programming					1701:1711	maternal nutritional programming	1680:1711	maternal nutritional programming in neonates and insights for future application of GOS in maternal-neonatal nutrition	1680:1797	Our findings provide evidence for maternal nutritional programming in neonates and insights for future application of GOS in maternal-neonatal nutrition.
34165467	2	15	from	effects	230:236	arg1	colonization					307:318	microbial colonization	297:318	microbial colonization	297:318	However, the effects of nutritional programming by maternal GOS intervention on microbial colonization and intestinal development in the offspring remain unclear.
34165467	2	15	from	effects	230:236	arg1	development					335:345	intestinal development	324:345	intestinal development	324:345	However, the effects of nutritional programming by maternal GOS intervention on microbial colonization and intestinal development in the offspring remain unclear.
34165467	9	16	from	application	1749:1759	arg1	nutrition					1789:1797	maternal-neonatal nutrition	1771:1797	maternal-neonatal nutrition	1771:1797	Our findings provide evidence for maternal nutritional programming in neonates and insights for future application of GOS in maternal-neonatal nutrition.
34165467	3	17	from	performances	507:518	arg1	day					603:605	day 21	603:608	day 21	603:608	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	3	17	from	performances	507:518	arg1	piglets					592:598	their piglets	586:598	their piglets	586:598	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	4	18	theme	pregnant	648:655	arg1	sows					657:660	pregnant sows	648:660	pregnant sows	648:660	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	3	19	theme	present	387:393	arg1	study					395:399	the present study	383:399	the present study	383:399	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	0	20	from	defense	67:73	arg1	piglets					129:135	piglets	129:135	piglets	129:135	Maternal galactooligosaccharides supplementation programmed immune defense, microbial colonization and intestinal development in piglets.
34165467	6	21	theme	P	1277:1277	arg1	Mucin-2					1268:1274	Mucin-2	1268:1274	Mucin-2 (P < 0.05)	1268:1285	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	21	theme	P	1277:1277	arg1	<					1279:1279	P < 0.05	1277:1284	P < 0.05	1277:1284	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	2	22	theme	microbial	297:305	arg1	colonization					307:318	microbial colonization	297:318	microbial colonization	297:318	However, the effects of nutritional programming by maternal GOS intervention on microbial colonization and intestinal development in the offspring remain unclear.
34165467	8	23	theme	piglets	1637:1643	arg1	performance					1618:1628	growth performance	1611:1628	growth performance	1611:1628	This neonatal programming showed positive potential in promoting the intestinal barriers, immune defense, and growth performance of the piglets.
34165467	8	23	theme	piglets	1637:1643	arg1	barriers					1581:1588	the intestinal barriers	1566:1588	the intestinal barriers	1566:1588	This neonatal programming showed positive potential in promoting the intestinal barriers, immune defense, and growth performance of the piglets.
34165467	8	23	theme	piglets	1637:1643	arg1	defense					1598:1604	immune defense	1591:1604	immune defense	1591:1604	This neonatal programming showed positive potential in promoting the intestinal barriers, immune defense, and growth performance of the piglets.
34165467	0	24	theme	galactooligosaccharides	9:31	arg1	supplementation					33:47	Maternal galactooligosaccharides supplementation	0:47	Maternal galactooligosaccharides supplementation	0:47	Maternal galactooligosaccharides supplementation programmed immune defense, microbial colonization and intestinal development in piglets.
34165467	4	25	from	levels	808:813	arg1	sows					823:826	sows	823:826	sows	823:826	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	4	25	from	levels	808:813	arg1	piglets					838:844	their piglets	832:844	their piglets (P < 0.05)	832:855	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	4	25	from	levels	808:813	arg1	<					849:849	P < 0.05	847:854	P < 0.05	847:854	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	3	26	dep	GOS	438:440	arg1	d-1					448:450	10 g d-1	443:450	10 g d-1 added into the diet	443:470	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	5	27	from	enriched	875:882	arg1	piglets					1024:1030	their piglets	1018:1030	their piglets (P < 0.05)	1018:1041	GOS intervention enriched fecal Alloprevotella and Ruminoclostridium_1 in gestational sows and vertically increased fecal Alloprevotella and Ruminococcaceae in their piglets (P < 0.05).
34165467	5	27	from	enriched	875:882	arg1	<					1035:1035	P < 0.05	1033:1040	P < 0.05	1033:1040	GOS intervention enriched fecal Alloprevotella and Ruminoclostridium_1 in gestational sows and vertically increased fecal Alloprevotella and Ruminococcaceae in their piglets (P < 0.05).
34165467	4	28	theme	piglets	736:742	arg1	characteristics					684:698	their litter characteristics	671:698	their litter characteristics	671:698	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	4	28	theme	piglets	736:742	arg1	performance					715:725	the growth performance	704:725	the growth performance	704:725	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	6	29	theme	goblet	1245:1250	arg1	junctions					1202:1210	intestinal tight junctions	1185:1210	intestinal tight junctions (Occludin, Claudin-1, ZO-1)	1185:1238	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	29	theme	goblet	1245:1250	arg1	number					1257:1262	the goblet cell number	1241:1262	the goblet cell number	1241:1262	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	0	30	theme	Maternal	0:7	arg1	supplementation					33:47	Maternal galactooligosaccharides supplementation	0:47	Maternal galactooligosaccharides supplementation	0:47	Maternal galactooligosaccharides supplementation programmed immune defense, microbial colonization and intestinal development in piglets.
34165467	1	31	from	benefits	142:149	arg1	neonates					187:194	neonates	187:194	neonates	187:194	The benefits of galactooligosaccharides (GOS) in neonates have been confirmed.
34165467	3	32	theme	intestinal	563:572	arg1	barriers					574:581	intestinal barriers	563:581	intestinal barriers	563:581	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	3	33	from	barriers	574:581	arg1	day					603:605	day 21	603:608	day 21	603:608	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	3	33	from	barriers	574:581	arg1	piglets					592:598	their piglets	586:598	their piglets	586:598	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	3	34	theme	g	446:446	arg1	d-1					448:450	10 g d-1	443:450	10 g d-1 added into the diet	443:470	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	3	35	theme	late	402:405	arg1	sows					419:422	late gestational sows	402:422	late gestational sows	402:422	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	5	36	theme	fecal	974:978	arg1	Alloprevotella					980:993	vertically increased fecal Alloprevotella	953:993	vertically increased fecal Alloprevotella	953:993	GOS intervention enriched fecal Alloprevotella and Ruminoclostridium_1 in gestational sows and vertically increased fecal Alloprevotella and Ruminococcaceae in their piglets (P < 0.05).
34165467	8	37	theme	growth	1611:1616	arg1	performance					1618:1628	growth performance	1611:1628	growth performance	1611:1628	This neonatal programming showed positive potential in promoting the intestinal barriers, immune defense, and growth performance of the piglets.
34165467	9	38	theme	future	1742:1747	arg1	application					1749:1759	future application	1742:1759	future application of GOS in maternal-neonatal nutrition	1742:1797	Our findings provide evidence for maternal nutritional programming in neonates and insights for future application of GOS in maternal-neonatal nutrition.
34165467	3	39	theme	microbiota	536:545	arg1	composition					547:557	microbiota composition	536:557	microbiota composition	536:557	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	3	40	theme	gestational	407:417	arg1	sows					419:422	late gestational sows	402:422	late gestational sows	402:422	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	6	41	theme	intestinal	1132:1141	arg1	barriers					1143:1150	the intestinal barriers	1128:1150	the intestinal barriers of their piglets	1128:1167	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	0	42	from	development	114:124	arg1	piglets					129:135	piglets	129:135	piglets	129:135	Maternal galactooligosaccharides supplementation programmed immune defense, microbial colonization and intestinal development in piglets.
34165467	6	43	theme	P	1105:1105	arg1	acetate					1096:1102	fecal acetate	1090:1102	fecal acetate (P < 0.05)	1090:1113	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	43	theme	P	1105:1105	arg1	<					1107:1107	P < 0.05	1105:1112	P < 0.05	1105:1112	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	4	44	from	supplementation	629:643	arg1	sows					657:660	pregnant sows	648:660	pregnant sows	648:660	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	7	45	theme	specific	1455:1462	arg1	microbes					1464:1471	maternal specific microbes	1446:1471	maternal specific microbes	1446:1471	In summary, GOS supplementation for sows during late gestation nutritionally programmed maternal specific microbes and IgA of their offspring.
34165467	6	46	theme	tight	1196:1200	arg1	junctions					1202:1210	intestinal tight junctions	1185:1210	intestinal tight junctions (Occludin, Claudin-1, ZO-1)	1185:1238	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	46	theme	tight	1196:1200	arg1	Mucin-2					1268:1274	Mucin-2	1268:1274	Mucin-2 (P < 0.05)	1268:1285	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	46	theme	tight	1196:1200	arg1	number					1257:1262	the goblet cell number	1241:1262	the goblet cell number	1241:1262	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	0	47	theme	immune	60:65	arg1	defense					67:73	immune defense	60:73	immune defense	60:73	Maternal galactooligosaccharides supplementation programmed immune defense, microbial colonization and intestinal development in piglets.
34165467	6	48	theme	colonized	1325:1333	arg1	microbiota					1335:1344	the colonized microbiota	1321:1344	the colonized microbiota (P < 0.05)	1321:1355	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	48	theme	colonized	1325:1333	arg1	<					1349:1349	P < 0.05	1347:1354	P < 0.05	1347:1354	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	9	49	from	programming	1701:1711	arg1	insights					1729:1736	insights	1729:1736	insights	1729:1736	Our findings provide evidence for maternal nutritional programming in neonates and insights for future application of GOS in maternal-neonatal nutrition.
34165467	9	49	from	programming	1701:1711	arg1	neonates					1716:1723	neonates	1716:1723	neonates	1716:1723	Our findings provide evidence for maternal nutritional programming in neonates and insights for future application of GOS in maternal-neonatal nutrition.
34165467	2	50	theme	programming	253:263	arg1	effects					230:236	the effects	226:236	the effects of nutritional programming by maternal GOS intervention on microbial colonization and intestinal development in the offspring	226:362	However, the effects of nutritional programming by maternal GOS intervention on microbial colonization and intestinal development in the offspring remain unclear.
34165467	4	51	theme	GOS	625:627	arg1	supplementation					629:643	GOS supplementation	625:643	GOS supplementation in pregnant sows	625:660	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	0	52	theme	microbial	76:84	arg1	colonization					86:97	microbial colonization	76:97	microbial colonization	76:97	Maternal galactooligosaccharides supplementation programmed immune defense, microbial colonization and intestinal development in piglets.
34165467	6	53	theme	cell	1252:1255	arg1	junctions					1202:1210	intestinal tight junctions	1185:1210	intestinal tight junctions (Occludin, Claudin-1, ZO-1)	1185:1238	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	53	theme	cell	1252:1255	arg1	number					1257:1262	the goblet cell number	1241:1262	the goblet cell number	1241:1262	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	0	54	from	colonization	86:97	arg1	piglets					129:135	piglets	129:135	piglets	129:135	Maternal galactooligosaccharides supplementation programmed immune defense, microbial colonization and intestinal development in piglets.
34165467	2	55	theme	nutritional	241:251	arg1	programming					253:263	nutritional programming	241:263	nutritional programming by maternal GOS intervention	241:292	However, the effects of nutritional programming by maternal GOS intervention on microbial colonization and intestinal development in the offspring remain unclear.
34165467	4	56	theme	growth	708:713	arg1	performance					715:725	the growth performance	704:725	the growth performance	704:725	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	9	57	theme	maternal-neonatal	1771:1787	arg1	nutrition					1789:1797	maternal-neonatal nutrition	1771:1797	maternal-neonatal nutrition	1771:1797	Our findings provide evidence for maternal nutritional programming in neonates and insights for future application of GOS in maternal-neonatal nutrition.
34165467	4	58	theme	P	847:847	arg1	piglets					838:844	their piglets	832:844	their piglets (P < 0.05)	832:855	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	4	58	theme	P	847:847	arg1	<					849:849	P < 0.05	847:854	P < 0.05	847:854	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	7	59	theme	late	1406:1409	arg1	gestation					1411:1419	late gestation	1406:1419	late gestation	1406:1419	In summary, GOS supplementation for sows during late gestation nutritionally programmed maternal specific microbes and IgA of their offspring.
34165467	4	60	theme	plasma	797:802	arg1	levels					808:813	the plasma IgA levels	793:813	the plasma IgA levels in both sows and their piglets (P < 0.05)	793:855	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	5	61	theme	GOS	858:860	arg1	intervention					862:873	GOS intervention	858:873	GOS intervention	858:873	GOS intervention enriched fecal Alloprevotella and Ruminoclostridium_1 in gestational sows and vertically increased fecal Alloprevotella and Ruminococcaceae in their piglets (P < 0.05).
34165467	2	62	from	colonization	307:318	arg1	offspring					354:362	the offspring	350:362	the offspring	350:362	However, the effects of nutritional programming by maternal GOS intervention on microbial colonization and intestinal development in the offspring remain unclear.
34165467	6	63	theme	piglets	1161:1167	arg1	barriers					1143:1150	the intestinal barriers	1128:1150	the intestinal barriers of their piglets	1128:1167	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	64	theme	intestinal	1185:1194	arg1	junctions					1202:1210	intestinal tight junctions	1185:1210	intestinal tight junctions (Occludin, Claudin-1, ZO-1)	1185:1238	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	64	theme	intestinal	1185:1194	arg1	Mucin-2					1268:1274	Mucin-2	1268:1274	Mucin-2 (P < 0.05)	1268:1285	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	64	theme	intestinal	1185:1194	arg1	number					1257:1262	the goblet cell number	1241:1262	the goblet cell number	1241:1262	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	1	65	theme	galactooligosaccharides	154:176	arg1	benefits					142:149	The benefits	138:149	The benefits of galactooligosaccharides (GOS) in neonates	138:194	The benefits of galactooligosaccharides (GOS) in neonates have been confirmed.
34165467	3	66	from	composition	547:557	arg1	day					603:605	day 21	603:608	day 21	603:608	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	3	66	from	composition	547:557	arg1	piglets					592:598	their piglets	586:598	their piglets	586:598	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	9	67	theme	maternal	1680:1687	arg1	programming					1701:1711	maternal nutritional programming	1680:1711	maternal nutritional programming in neonates and insights for future application of GOS in maternal-neonatal nutrition	1680:1797	Our findings provide evidence for maternal nutritional programming in neonates and insights for future application of GOS in maternal-neonatal nutrition.
34165467	3	68	theme	immune	521:526	arg1	status					528:533	immune status	521:533	immune status	521:533	In the present study, late gestational sows were fed with GOS (10 g d-1 added into the diet) or not until parturition, and the performances, immune status, microbiota composition and intestinal barriers in their piglets on day 21 were compared.
34165467	5	69	theme	P	1033:1033	arg1	piglets					1024:1030	their piglets	1018:1030	their piglets (P < 0.05)	1018:1041	GOS intervention enriched fecal Alloprevotella and Ruminoclostridium_1 in gestational sows and vertically increased fecal Alloprevotella and Ruminococcaceae in their piglets (P < 0.05).
34165467	5	69	theme	P	1033:1033	arg1	<					1035:1035	P < 0.05	1033:1040	P < 0.05	1033:1040	GOS intervention enriched fecal Alloprevotella and Ruminoclostridium_1 in gestational sows and vertically increased fecal Alloprevotella and Ruminococcaceae in their piglets (P < 0.05).
34165467	5	70	theme	increased	964:972	arg1	Alloprevotella					980:993	vertically increased fecal Alloprevotella	953:993	vertically increased fecal Alloprevotella	953:993	GOS intervention enriched fecal Alloprevotella and Ruminoclostridium_1 in gestational sows and vertically increased fecal Alloprevotella and Ruminococcaceae in their piglets (P < 0.05).
34165467	9	71	from	nutrition	1789:1797	arg1	application					1749:1759	future application	1742:1759	future application of GOS in maternal-neonatal nutrition	1742:1797	Our findings provide evidence for maternal nutritional programming in neonates and insights for future application of GOS in maternal-neonatal nutrition.
34165467	8	72	theme	immune	1591:1596	arg1	defense					1598:1604	immune defense	1591:1604	immune defense	1591:1604	This neonatal programming showed positive potential in promoting the intestinal barriers, immune defense, and growth performance of the piglets.
34165467	6	73	theme	fecal	1090:1094	arg1	acetate					1096:1102	fecal acetate	1090:1102	fecal acetate (P < 0.05)	1090:1113	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	73	theme	fecal	1090:1094	arg1	<					1107:1107	P < 0.05	1105:1112	P < 0.05	1105:1112	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	74	theme	P	1347:1347	arg1	microbiota					1335:1344	the colonized microbiota	1321:1344	the colonized microbiota (P < 0.05)	1321:1355	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	74	theme	P	1347:1347	arg1	<					1349:1349	P < 0.05	1347:1354	P < 0.05	1347:1354	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	2	75	theme	GOS	277:279	arg1	intervention					281:292	maternal GOS intervention	268:292	maternal GOS intervention	268:292	However, the effects of nutritional programming by maternal GOS intervention on microbial colonization and intestinal development in the offspring remain unclear.
34165467	4	76	theme	litter	677:682	arg1	characteristics					684:698	their litter characteristics	671:698	their litter characteristics	671:698	GOS supplementation in pregnant sows improved their litter characteristics and the growth performance of their piglets during the neonatal stage (day 21), and elevated the plasma IgA levels in both sows and their piglets (P < 0.05).
34165467	8	77	theme	intestinal	1570:1579	arg1	barriers					1581:1588	the intestinal barriers	1566:1588	the intestinal barriers	1566:1588	This neonatal programming showed positive potential in promoting the intestinal barriers, immune defense, and growth performance of the piglets.
34165467	8	78	theme	positive	1534:1541	arg1	potential					1543:1551	positive potential	1534:1551	positive potential	1534:1551	This neonatal programming showed positive potential in promoting the intestinal barriers, immune defense, and growth performance of the piglets.
34165467	6	79	dep	junctions	1202:1210	arg1	Occludin					1213:1220	Occludin	1213:1220	Occludin	1213:1220	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	79	dep	junctions	1202:1210	arg1	ZO-1					1234:1237	ZO-1	1234:1237	ZO-1	1234:1237	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	6	79	dep	junctions	1202:1210	arg1	Claudin-1					1223:1231	Claudin-1	1223:1231	Claudin-1	1223:1231	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	2	80	theme	maternal	268:275	arg1	intervention					281:292	maternal GOS intervention	268:292	maternal GOS intervention	268:292	However, the effects of nutritional programming by maternal GOS intervention on microbial colonization and intestinal development in the offspring remain unclear.
34165467	6	81	theme	GOS	1063:1065	arg1	intervention					1067:1078	maternal GOS intervention	1054:1078	maternal GOS intervention	1054:1078	Moreover, maternal GOS intervention increased fecal acetate (P < 0.05) and improved the intestinal barriers of their piglets by upregulating intestinal tight junctions (Occludin, Claudin-1, ZO-1), the goblet cell number and Mucin-2 (P < 0.05), which correlated positively with the colonized microbiota (P < 0.05).
34165467	7	82	theme	offspring	1490:1498	arg1	IgA					1477:1479	IgA	1477:1479	IgA	1477:1479	In summary, GOS supplementation for sows during late gestation nutritionally programmed maternal specific microbes and IgA of their offspring.
34165467	7	82	theme	offspring	1490:1498	arg1	microbes					1464:1471	maternal specific microbes	1446:1471	maternal specific microbes	1446:1471	In summary, GOS supplementation for sows during late gestation nutritionally programmed maternal specific microbes and IgA of their offspring.
32793574	6	0	theme	biochemical/physical	1059:1078	arg1	features					1080:1087	different biochemical/physical features	1049:1087	different biochemical/physical features	1049:1087	Affinity purified IgG variants are shown to be fully assembled to heterodimers but display different biochemical/physical features.
32793574	2	1	theme	distinct	342:349	arg1	subtypes					355:362	distinct IgG subtypes	342:362	distinct IgG subtypes	342:362	However, very little is known about the biological consequences mainly due to the difficulties in the generation of distinct IgG subtypes with targeted glycosylation.
32793574	7	2	theme	oligo-mannosidic	1241:1256	arg1	structures					1258:1267	unusual oligo-mannosidic structures	1233:1267	unusual oligo-mannosidic structures	1233:1267	All subtypes are equally well amenable to targeted glycosylation, except sialylated IgG4 which frequently accumulates substantial fractions of unusual oligo-mannosidic structures.
32793574	3	3	theme	binding	528:534	arg1	domain					536:541	their antigen binding domain	514:541	their antigen binding domain	514:541	Here, we show a comprehensive expression and glycan modulation profiling of IgG variants in planta that are identical in their antigen binding domain but differ in their subclass appearance.
32793574	8	4	theme	IgG	1270:1272	arg1	variants					1274:1281	IgG variants	1270:1281	IgG variants	1270:1281	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	3	5	theme	subclass	563:570	arg1	appearance					572:581	their subclass appearance	557:581	their subclass appearance	557:581	Here, we show a comprehensive expression and glycan modulation profiling of IgG variants in planta that are identical in their antigen binding domain but differ in their subclass appearance.
32793574	8	6	dep	steps	1408:1412	arg1	chromatography					1430:1443	size exclusion chromatography	1415:1443	size exclusion chromatography	1415:1443	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	8	6	dep	steps	1408:1412	arg1	treatments					1464:1473	endotoxin removal treatments	1446:1473	endotoxin removal treatments	1446:1473	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	6	7	theme	different	1049:1057	arg1	features					1080:1087	different biochemical/physical features	1049:1087	different biochemical/physical features	1049:1087	Affinity purified IgG variants are shown to be fully assembled to heterodimers but display different biochemical/physical features.
32793574	1	8	theme	distinctive	190:200	arg1	profiles					216:223	distinctive glycosylation profiles	190:223	distinctive glycosylation profiles	190:223	IgG, the main serum immunoglobulin isotype, exists in four subclasses which selectively appear with distinctive glycosylation profiles.
32793574	9	9	theme	high	1542:1545	arg1	purity					1547:1552	high purity	1542:1552	high purity	1542:1552	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	4	10	theme	expression	621:630	arg1	levels					632:637	similar expression levels	613:637	similar expression levels	613:637	While IgG1, 2, and 4 exhibit similar expression levels and purification yields, IgG3 is generated only at low levels due to the in planta degradation of the heavy chain.
32793574	9	11	theme	variants	1530:1537	arg1	generation					1509:1518	the generation	1505:1518	the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation	1505:1714	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	8	12	theme	aggregate	1315:1323	arg1	formation					1325:1333	aggregate formation	1315:1333	aggregate formation	1315:1333	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	5	13	theme	impact	877:882	arg1	activities					888:897	impact IgG activities	877:897	impact IgG activities	877:897	All IgG subtypes are produced with four distinct N-glycosylation profiles, differing in sugar residues previously shown to impact IgG activities, i.e., galactosylation, sialylation and core fucosylation.
32793574	8	14	theme	exclusion	1420:1428	arg1	chromatography					1430:1443	size exclusion chromatography	1415:1443	size exclusion chromatography	1415:1443	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	8	14	theme	exclusion	1420:1428	arg1	treatments					1464:1473	endotoxin removal treatments	1446:1473	endotoxin removal treatments	1446:1473	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	8	15	from	differences	1300:1310	arg1	formation					1325:1333	aggregate formation	1315:1333	aggregate formation	1315:1333	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	8	15	from	differences	1300:1310	arg1	contamination					1349:1361	endotoxin contamination	1339:1361	endotoxin contamination	1339:1361	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	1	16	theme	immunoglobulin	110:123	arg1	IgG					90:92	IgG	90:92	IgG	90:92	IgG, the main serum immunoglobulin isotype, exists in four subclasses which selectively appear with distinctive glycosylation profiles.
32793574	1	16	theme	immunoglobulin	110:123	arg1	isotype					125:131	the main serum immunoglobulin isotype	95:131	the main serum immunoglobulin isotype	95:131	IgG, the main serum immunoglobulin isotype, exists in four subclasses which selectively appear with distinctive glycosylation profiles.
32793574	7	17	theme	unusual	1233:1239	arg1	structures					1258:1267	unusual oligo-mannosidic structures	1233:1267	unusual oligo-mannosidic structures	1233:1267	All subtypes are equally well amenable to targeted glycosylation, except sialylated IgG4 which frequently accumulates substantial fractions of unusual oligo-mannosidic structures.
32793574	9	18	theme	glycan	1564:1569	arg1	homogeneity					1571:1581	large glycan homogeneity	1558:1581	large glycan homogeneity	1558:1581	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	6	19	theme	IgG	976:978	arg1	variants					980:987	Affinity purified IgG variants	958:987	Affinity purified IgG variants	958:987	Affinity purified IgG variants are shown to be fully assembled to heterodimers but display different biochemical/physical features.
32793574	0	20	theme	Nicotiana	67:75	arg1	benthamiana					77:87	Nicotiana benthamiana	67:87	Nicotiana benthamiana	67:87	Expression Profiling and Glycan Engineering of IgG Subclass 1-4 in Nicotiana benthamiana.
32793574	2	21	from	difficulties	308:319	arg1	generation					328:337	the generation	324:337	the generation of distinct IgG subtypes with targeted glycosylation	324:390	However, very little is known about the biological consequences mainly due to the difficulties in the generation of distinct IgG subtypes with targeted glycosylation.
32793574	8	22	theme	polishing	1398:1406	arg1	steps					1408:1412	additional polishing steps	1387:1412	additional polishing steps (size exclusion chromatography, endotoxin removal treatments)	1387:1474	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	5	23	theme	core	939:942	arg1	fucosylation					944:955	core fucosylation	939:955	core fucosylation	939:955	All IgG subtypes are produced with four distinct N-glycosylation profiles, differing in sugar residues previously shown to impact IgG activities, i.e., galactosylation, sialylation and core fucosylation.
32793574	5	23	theme	core	939:942	arg1	profiles					819:826	four distinct N-glycosylation profiles	789:826	four distinct N-glycosylation profiles	789:826	All IgG subtypes are produced with four distinct N-glycosylation profiles, differing in sugar residues previously shown to impact IgG activities, i.e., galactosylation, sialylation and core fucosylation.
32793574	0	24	from	Engineering	32:42	arg1	benthamiana					77:87	Nicotiana benthamiana	67:87	Nicotiana benthamiana	67:87	Expression Profiling and Glycan Engineering of IgG Subclass 1-4 in Nicotiana benthamiana.
32793574	3	25	theme	comprehensive	409:421	arg1	expression					423:432	a comprehensive expression and glycan modulation profiling	407:464	expression	423:432	Here, we show a comprehensive expression and glycan modulation profiling of IgG variants in planta that are identical in their antigen binding domain but differ in their subclass appearance.
32793574	0	26	theme	Expression	0:9	arg1	Profiling					11:19	Expression Profiling	0:19	Expression Profiling	0:19	Expression Profiling and Glycan Engineering of IgG Subclass 1-4 in Nicotiana benthamiana.
32793574	4	27	theme	in	712:713	arg1	degradation					722:732	the in planta degradation	708:732	the in planta degradation of the heavy chain	708:751	While IgG1, 2, and 4 exhibit similar expression levels and purification yields, IgG3 is generated only at low levels due to the in planta degradation of the heavy chain.
32793574	3	28	theme	antigen	520:526	arg1	domain					536:541	their antigen binding domain	514:541	their antigen binding domain	514:541	Here, we show a comprehensive expression and glycan modulation profiling of IgG variants in planta that are identical in their antigen binding domain but differ in their subclass appearance.
32793574	5	29	theme	sugar	842:846	arg1	residues					848:855	sugar residues	842:855	sugar residues previously shown to impact IgG activities	842:897	All IgG subtypes are produced with four distinct N-glycosylation profiles, differing in sugar residues previously shown to impact IgG activities, i.e., galactosylation, sialylation and core fucosylation.
32793574	7	30	theme	sialylated	1163:1172	arg1	IgG4					1174:1177	sialylated IgG4	1163:1177	sialylated IgG4 which frequently accumulates substantial fractions of unusual oligo-mannosidic structures	1163:1267	All subtypes are equally well amenable to targeted glycosylation, except sialylated IgG4 which frequently accumulates substantial fractions of unusual oligo-mannosidic structures.
32793574	3	31	theme	modulation	445:454	arg1	profiling					456:464	a comprehensive expression and glycan modulation profiling	407:464	profiling	456:464	Here, we show a comprehensive expression and glycan modulation profiling of IgG variants in planta that are identical in their antigen binding domain but differ in their subclass appearance.
32793574	7	32	theme	targeted	1132:1139	arg1	glycosylation					1141:1153	targeted glycosylation	1132:1153	targeted glycosylation	1132:1153	All subtypes are equally well amenable to targeted glycosylation, except sialylated IgG4 which frequently accumulates substantial fractions of unusual oligo-mannosidic structures.
32793574	8	33	theme	removal	1456:1462	arg1	chromatography					1430:1443	size exclusion chromatography	1415:1443	size exclusion chromatography	1415:1443	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	8	33	theme	removal	1456:1462	arg1	treatments					1464:1473	endotoxin removal treatments	1446:1473	endotoxin removal treatments	1446:1473	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	3	34	from	profiling	456:464	arg1	planta					485:490	planta	485:490	planta that are identical in their antigen binding domain but differ in their subclass appearance	485:581	Here, we show a comprehensive expression and glycan modulation profiling of IgG variants in planta that are identical in their antigen binding domain but differ in their subclass appearance.
32793574	0	35	theme	IgG	47:49	arg1	Subclass					51:58	IgG Subclass 1-4	47:62	IgG Subclass 1-4	47:62	Expression Profiling and Glycan Engineering of IgG Subclass 1-4 in Nicotiana benthamiana.
32793574	7	36	gly	sialylated	1163:1172	arg1	IgG4					1174:1177	sialylated IgG4	1163:1177	sialylated IgG4 which frequently accumulates substantial fractions of unusual oligo-mannosidic structures	1163:1267	All subtypes are equally well amenable to targeted glycosylation, except sialylated IgG4 which frequently accumulates substantial fractions of unusual oligo-mannosidic structures.
32793574	3	37	theme	variants	473:480	arg1	profiling					456:464	a comprehensive expression and glycan modulation profiling	407:464	profiling	456:464	Here, we show a comprehensive expression and glycan modulation profiling of IgG variants in planta that are identical in their antigen binding domain but differ in their subclass appearance.
32793574	3	37	theme	variants	473:480	arg1	expression					423:432	a comprehensive expression and glycan modulation profiling	407:464	expression	423:432	Here, we show a comprehensive expression and glycan modulation profiling of IgG variants in planta that are identical in their antigen binding domain but differ in their subclass appearance.
32793574	9	38	theme	main	1671:1674	arg1	glycosylation					1702:1714	glycosylation	1702:1714	glycosylation	1702:1714	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	9	38	theme	main	1671:1674	arg1	subclass					1689:1696	subclass	1689:1696	subclass	1689:1696	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	9	38	theme	main	1671:1674	arg1	features					1679:1686	the two main Fc features	1663:1686	the two main Fc features	1663:1686	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	8	39	theme	endotoxin	1339:1347	arg1	contamination					1349:1361	endotoxin contamination	1339:1361	endotoxin contamination	1339:1361	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	3	40	from	expression	423:432	arg1	planta					485:490	planta	485:490	planta that are identical in their antigen binding domain but differ in their subclass appearance	485:581	Here, we show a comprehensive expression and glycan modulation profiling of IgG variants in planta that are identical in their antigen binding domain but differ in their subclass appearance.
32793574	9	41	theme	features	1679:1686	arg1	impact					1653:1658	the biological impact	1638:1658	the biological impact of the two main Fc features, subclass and glycosylation	1638:1714	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	2	42	theme	IgG	351:353	arg1	subtypes					355:362	distinct IgG subtypes	342:362	distinct IgG subtypes	342:362	However, very little is known about the biological consequences mainly due to the difficulties in the generation of distinct IgG subtypes with targeted glycosylation.
32793574	9	43	from	homogeneity	1571:1581	arg1	generation					1509:1518	the generation	1505:1518	the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation	1505:1714	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	7	44	theme	structures	1258:1267	arg1	fractions					1220:1228	substantial fractions	1208:1228	substantial fractions of unusual oligo-mannosidic structures	1208:1267	All subtypes are equally well amenable to targeted glycosylation, except sialylated IgG4 which frequently accumulates substantial fractions of unusual oligo-mannosidic structures.
32793574	3	45	from	identical	501:509	arg1	domain					536:541	their antigen binding domain	514:541	their antigen binding domain	514:541	Here, we show a comprehensive expression and glycan modulation profiling of IgG variants in planta that are identical in their antigen binding domain but differ in their subclass appearance.
32793574	2	46	theme	biological	266:275	arg1	consequences					277:288	the biological consequences	262:288	the biological consequences mainly due to the difficulties in the generation of distinct IgG subtypes with targeted glycosylation	262:390	However, very little is known about the biological consequences mainly due to the difficulties in the generation of distinct IgG subtypes with targeted glycosylation.
32793574	9	47	from	purity	1547:1552	arg1	generation					1509:1518	the generation	1505:1518	the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation	1505:1714	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	6	48	dep	purified	967:974	arg1	Affinity					958:965	Affinity	958:965	Affinity	958:965	Affinity purified IgG variants are shown to be fully assembled to heterodimers but display different biochemical/physical features.
32793574	4	49	theme	purification	643:654	arg1	yields					656:661	purification yields	643:661	purification yields	643:661	While IgG1, 2, and 4 exhibit similar expression levels and purification yields, IgG3 is generated only at low levels due to the in planta degradation of the heavy chain.
32793574	5	50	theme	distinct	794:801	arg1	sialylation					923:933	sialylation	923:933	sialylation	923:933	All IgG subtypes are produced with four distinct N-glycosylation profiles, differing in sugar residues previously shown to impact IgG activities, i.e., galactosylation, sialylation and core fucosylation.
32793574	5	50	theme	distinct	794:801	arg1	fucosylation					944:955	core fucosylation	939:955	core fucosylation	939:955	All IgG subtypes are produced with four distinct N-glycosylation profiles, differing in sugar residues previously shown to impact IgG activities, i.e., galactosylation, sialylation and core fucosylation.
32793574	5	50	theme	distinct	794:801	arg1	profiles					819:826	four distinct N-glycosylation profiles	789:826	four distinct N-glycosylation profiles	789:826	All IgG subtypes are produced with four distinct N-glycosylation profiles, differing in sugar residues previously shown to impact IgG activities, i.e., galactosylation, sialylation and core fucosylation.
32793574	4	51	theme	similar	613:619	arg1	levels					632:637	similar expression levels	613:637	similar expression levels	613:637	While IgG1, 2, and 4 exhibit similar expression levels and purification yields, IgG3 is generated only at low levels due to the in planta degradation of the heavy chain.
32793574	1	52	theme	main	99:102	arg1	IgG					90:92	IgG	90:92	IgG	90:92	IgG, the main serum immunoglobulin isotype, exists in four subclasses which selectively appear with distinctive glycosylation profiles.
32793574	1	52	theme	main	99:102	arg1	isotype					125:131	the main serum immunoglobulin isotype	95:131	the main serum immunoglobulin isotype	95:131	IgG, the main serum immunoglobulin isotype, exists in four subclasses which selectively appear with distinctive glycosylation profiles.
32793574	4	53	theme	chain	747:751	arg1	degradation					722:732	the in planta degradation	708:732	the in planta degradation of the heavy chain	708:751	While IgG1, 2, and 4 exhibit similar expression levels and purification yields, IgG3 is generated only at low levels due to the in planta degradation of the heavy chain.
32793574	5	54	theme	IgG	884:886	arg1	activities					888:897	impact IgG activities	877:897	impact IgG activities	877:897	All IgG subtypes are produced with four distinct N-glycosylation profiles, differing in sugar residues previously shown to impact IgG activities, i.e., galactosylation, sialylation and core fucosylation.
32793574	4	55	theme	low	690:692	arg1	levels					694:699	low levels	690:699	low levels due to the in planta degradation of the heavy chain	690:751	While IgG1, 2, and 4 exhibit similar expression levels and purification yields, IgG3 is generated only at low levels due to the in planta degradation of the heavy chain.
32793574	9	56	theme	large	1558:1562	arg1	homogeneity					1571:1581	large glycan homogeneity	1558:1581	large glycan homogeneity	1558:1581	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	1	57	theme	serum	104:108	arg1	IgG					90:92	IgG	90:92	IgG	90:92	IgG, the main serum immunoglobulin isotype, exists in four subclasses which selectively appear with distinctive glycosylation profiles.
32793574	1	57	theme	serum	104:108	arg1	isotype					125:131	the main serum immunoglobulin isotype	95:131	the main serum immunoglobulin isotype	95:131	IgG, the main serum immunoglobulin isotype, exists in four subclasses which selectively appear with distinctive glycosylation profiles.
32793574	5	58	dep	galactosylation	906:920	arg1	i.e.					900:903	i.e.	900:903	i.e.	900:903	All IgG subtypes are produced with four distinct N-glycosylation profiles, differing in sugar residues previously shown to impact IgG activities, i.e., galactosylation, sialylation and core fucosylation.
32793574	7	59	theme	substantial	1208:1218	arg1	fractions					1220:1228	substantial fractions	1208:1228	substantial fractions of unusual oligo-mannosidic structures	1208:1267	All subtypes are equally well amenable to targeted glycosylation, except sialylated IgG4 which frequently accumulates substantial fractions of unusual oligo-mannosidic structures.
32793574	6	60	theme	purified	967:974	arg1	variants					980:987	Affinity purified IgG variants	958:987	Affinity purified IgG variants	958:987	Affinity purified IgG variants are shown to be fully assembled to heterodimers but display different biochemical/physical features.
32793574	0	61	from	Profiling	11:19	arg1	benthamiana					77:87	Nicotiana benthamiana	67:87	Nicotiana benthamiana	67:87	Expression Profiling and Glycan Engineering of IgG Subclass 1-4 in Nicotiana benthamiana.
32793574	3	62	from	domain	536:541	arg1	identical					501:509	identical	501:509	identical	501:509	Here, we show a comprehensive expression and glycan modulation profiling of IgG variants in planta that are identical in their antigen binding domain but differ in their subclass appearance.
32793574	2	63	theme	due	297:299	arg1	consequences					277:288	the biological consequences	262:288	the biological consequences mainly due to the difficulties in the generation of distinct IgG subtypes with targeted glycosylation	262:390	However, very little is known about the biological consequences mainly due to the difficulties in the generation of distinct IgG subtypes with targeted glycosylation.
32793574	4	64	theme	planta	715:720	arg1	degradation					722:732	the in planta degradation	708:732	the in planta degradation of the heavy chain	708:751	While IgG1, 2, and 4 exhibit similar expression levels and purification yields, IgG3 is generated only at low levels due to the in planta degradation of the heavy chain.
32793574	9	65	theme	excellent	1603:1611	arg1	toolbox					1613:1619	an excellent toolbox	1600:1619	an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation	1600:1714	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	8	66	theme	additional	1387:1396	arg1	steps					1408:1412	additional polishing steps	1387:1412	additional polishing steps (size exclusion chromatography, endotoxin removal treatments)	1387:1474	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	1	67	theme	glycosylation	202:214	arg1	profiles					216:223	distinctive glycosylation profiles	190:223	distinctive glycosylation profiles	190:223	IgG, the main serum immunoglobulin isotype, exists in four subclasses which selectively appear with distinctive glycosylation profiles.
32793574	3	68	theme	glycan	438:443	arg1	profiling					456:464	a comprehensive expression and glycan modulation profiling	407:464	profiling	456:464	Here, we show a comprehensive expression and glycan modulation profiling of IgG variants in planta that are identical in their antigen binding domain but differ in their subclass appearance.
32793574	5	69	theme	IgG	758:760	arg1	subtypes					762:769	All IgG subtypes	754:769	All IgG subtypes	754:769	All IgG subtypes are produced with four distinct N-glycosylation profiles, differing in sugar residues previously shown to impact IgG activities, i.e., galactosylation, sialylation and core fucosylation.
32793574	2	70	gly	glycosylation	378:390	arg1	generation					328:337	the generation	324:337	the generation of distinct IgG subtypes with targeted glycosylation	324:390	However, very little is known about the biological consequences mainly due to the difficulties in the generation of distinct IgG subtypes with targeted glycosylation.
32793574	4	71	theme	due	701:703	arg1	levels					694:699	low levels	690:699	low levels due to the in planta degradation of the heavy chain	690:751	While IgG1, 2, and 4 exhibit similar expression levels and purification yields, IgG3 is generated only at low levels due to the in planta degradation of the heavy chain.
32793574	2	72	theme	targeted	369:376	arg1	glycosylation					378:390	targeted glycosylation	369:390	targeted glycosylation	369:390	However, very little is known about the biological consequences mainly due to the difficulties in the generation of distinct IgG subtypes with targeted glycosylation.
32793574	0	73	theme	Glycan	25:30	arg1	Engineering					32:42	Glycan Engineering	25:42	Glycan Engineering	25:42	Expression Profiling and Glycan Engineering of IgG Subclass 1-4 in Nicotiana benthamiana.
32793574	8	74	theme	size	1415:1418	arg1	chromatography					1430:1443	size exclusion chromatography	1415:1443	size exclusion chromatography	1415:1443	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	8	74	theme	size	1415:1418	arg1	treatments					1464:1473	endotoxin removal treatments	1446:1473	endotoxin removal treatments	1446:1473	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	3	75	theme	IgG	469:471	arg1	variants					473:480	IgG variants	469:480	IgG variants	469:480	Here, we show a comprehensive expression and glycan modulation profiling of IgG variants in planta that are identical in their antigen binding domain but differ in their subclass appearance.
32793574	9	76	theme	IgG	1526:1528	arg1	variants					1530:1537	16 IgG variants	1523:1537	16 IgG variants	1523:1537	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	9	77	theme	biological	1642:1651	arg1	impact					1653:1658	the biological impact	1638:1658	the biological impact of the two main Fc features, subclass and glycosylation	1638:1714	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	5	78	theme	N-glycosylation	803:817	arg1	sialylation					923:933	sialylation	923:933	sialylation	923:933	All IgG subtypes are produced with four distinct N-glycosylation profiles, differing in sugar residues previously shown to impact IgG activities, i.e., galactosylation, sialylation and core fucosylation.
32793574	5	78	theme	N-glycosylation	803:817	arg1	fucosylation					944:955	core fucosylation	939:955	core fucosylation	939:955	All IgG subtypes are produced with four distinct N-glycosylation profiles, differing in sugar residues previously shown to impact IgG activities, i.e., galactosylation, sialylation and core fucosylation.
32793574	5	78	theme	N-glycosylation	803:817	arg1	profiles					819:826	four distinct N-glycosylation profiles	789:826	four distinct N-glycosylation profiles	789:826	All IgG subtypes are produced with four distinct N-glycosylation profiles, differing in sugar residues previously shown to impact IgG activities, i.e., galactosylation, sialylation and core fucosylation.
32793574	0	79	theme	Subclass	51:58	arg1	Profiling					11:19	Expression Profiling	0:19	Expression Profiling	0:19	Expression Profiling and Glycan Engineering of IgG Subclass 1-4 in Nicotiana benthamiana.
32793574	0	79	theme	Subclass	51:58	arg1	Engineering					32:42	Glycan Engineering	25:42	Glycan Engineering	25:42	Expression Profiling and Glycan Engineering of IgG Subclass 1-4 in Nicotiana benthamiana.
32793574	2	80	with	generation	328:337	arg1	glycosylation					378:390	targeted glycosylation	369:390	targeted glycosylation	369:390	However, very little is known about the biological consequences mainly due to the difficulties in the generation of distinct IgG subtypes with targeted glycosylation.
32793574	8	81	theme	endotoxin	1446:1454	arg1	chromatography					1430:1443	size exclusion chromatography	1415:1443	size exclusion chromatography	1415:1443	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	8	81	theme	endotoxin	1446:1454	arg1	treatments					1464:1473	endotoxin removal treatments	1446:1473	endotoxin removal treatments	1446:1473	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	4	82	theme	heavy	741:745	arg1	chain					747:751	the heavy chain	737:751	the heavy chain	737:751	While IgG1, 2, and 4 exhibit similar expression levels and purification yields, IgG3 is generated only at low levels due to the in planta degradation of the heavy chain.
32793574	8	83	theme	significant	1288:1298	arg1	differences					1300:1310	significant differences	1288:1310	significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments)	1288:1474	IgG variants show significant differences in aggregate formation and endotoxin contamination which are eliminated by additional polishing steps (size exclusion chromatography, endotoxin removal treatments).
32793574	9	84	theme	Fc	1676:1677	arg1	glycosylation					1702:1714	glycosylation	1702:1714	glycosylation	1702:1714	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	9	84	theme	Fc	1676:1677	arg1	subclass					1689:1696	subclass	1689:1696	subclass	1689:1696	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	9	84	theme	Fc	1676:1677	arg1	features					1679:1686	the two main Fc features	1663:1686	the two main Fc features	1663:1686	Collectively we demonstrate the generation of 16 IgG variants at high purity and large glycan homogeneity which constitute an excellent toolbox to further study the biological impact of the two main Fc features, subclass and glycosylation.
32793574	2	85	theme	subtypes	355:362	arg1	generation					328:337	the generation	324:337	the generation of distinct IgG subtypes with targeted glycosylation	324:390	However, very little is known about the biological consequences mainly due to the difficulties in the generation of distinct IgG subtypes with targeted glycosylation.
34624878	7	0	theme	higher	1283:1288	arg1	bioactivity					1290:1300	higher bioactivity	1283:1300	higher bioactivity	1283:1300	Up to 20 wt% of monetite reinforced composite scaffolds exhibited higher bioactivity as compared to that observed in pure gelatin-based GM0scaffold.
34624878	3	1	theme	improved	566:573	arg1	strength					586:593	improved mechanical strength	566:593	improved mechanical strength	566:593	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	4	2	theme	>80	676:678	arg1	%					679:679	%	679:679	%	679:679	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	8	3	theme	red	1412:1414	arg1	assays					1416:1421	Simulated body fluid (SBF) study and alizarin red assays	1366:1421	assays	1416:1421	Simulated body fluid (SBF) study and alizarin red assays confirmed higher bio-mineralization ability of GM20as compared to that exhibited by GM0.
34624878	10	4	theme	conducive	1797:1805	arg1	environment					1807:1817	a more conducive environment	1790:1817	a more conducive environment to proliferate and subsequently differentiate into osteoblast lineage when exposed to GM20scaffolds rather than to GM0and GM10	1790:1944	MTT assay and alkaline phosphatase staining study indicated that MG-63 cells found a more conducive environment to proliferate and subsequently differentiate into osteoblast lineage when exposed to GM20scaffolds rather than to GM0and GM10.
34624878	3	5	with	microstructure	546:559	arg1	stability					599:607	stability	599:607	stability	599:607	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	3	5	with	microstructure	546:559	arg1	strength					586:593	improved mechanical strength	566:593	improved mechanical strength	566:593	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	11	6	theme	bone	2127:2130	arg1	tissues					2132:2138	bone tissues	2127:2138	bone tissues	2127:2138	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	4	7	theme	pore	715:718	arg1	distribution					725:736	3D interconnected pore size distribution	697:736	3D interconnected pore size distribution varying between 65 and 270 μm	697:766	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	8	8	theme	alizarin	1403:1410	arg1	assays					1416:1421	Simulated body fluid (SBF) study and alizarin red assays	1366:1421	assays	1416:1421	Simulated body fluid (SBF) study and alizarin red assays confirmed higher bio-mineralization ability of GM20as compared to that exhibited by GM0.
34624878	1	9	theme	chemical	230:237	arg1	properties					266:275	the chemical, mechanical and osteogenic properties	226:275	the chemical, mechanical and osteogenic properties	226:275	This study was aimed at fabricating monetite nanoparticles impregnated gelatin-based composite scaffold to improve the chemical, mechanical and osteogenic properties.
34624878	5	10	theme	monetite	900:907	arg1	addition					909:916	monetite addition	900:916	monetite addition	900:916	The average pore size of the prepared scaffold decreased with monetite addition as reflected in values of 210 μm for pure gelatin GM0scaffold and 118 μm registered by GM20scaffold.
34624878	1	11	theme	mechanical	240:249	arg1	properties					266:275	the chemical, mechanical and osteogenic properties	226:275	the chemical, mechanical and osteogenic properties	226:275	This study was aimed at fabricating monetite nanoparticles impregnated gelatin-based composite scaffold to improve the chemical, mechanical and osteogenic properties.
34624878	11	12	theme	defect	2159:2164	arg1	sites					2166:2170	musculoskeletal defect sites	2143:2170	musculoskeletal defect sites	2143:2170	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	10	13	theme	MG-63	1772:1776	arg1	cells					1778:1782	MG-63 cells	1772:1782	MG-63 cells	1772:1782	MTT assay and alkaline phosphatase staining study indicated that MG-63 cells found a more conducive environment to proliferate and subsequently differentiate into osteoblast lineage when exposed to GM20scaffolds rather than to GM0and GM10.
34624878	4	14	theme	field	784:788	arg1	microscopy					817:826	field emission scanning electron microscopy	784:826	field emission scanning electron microscopy analysis	784:835	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	10	15	theme	osteoblast	1870:1879	arg1	lineage					1881:1887	osteoblast lineage	1870:1887	osteoblast lineage	1870:1887	MTT assay and alkaline phosphatase staining study indicated that MG-63 cells found a more conducive environment to proliferate and subsequently differentiate into osteoblast lineage when exposed to GM20scaffolds rather than to GM0and GM10.
34624878	11	16	theme	%	1983:1983	arg1	candidate					2092:2100	an efficient candidate	2079:2100	an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites	2079:2170	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	11	16	theme	%	1983:1983	arg1	addition					1994:2001	up to 20 wt% monetite addition	1972:2001	up to 20 wt% monetite addition in gelatin	1972:2012	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	4	17	theme	scanning	799:806	arg1	microscopy					817:826	field emission scanning electron microscopy	784:826	field emission scanning electron microscopy analysis	784:835	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	11	18	theme	scaffolds	2056:2064	arg1	performance					2032:2042	the performance	2028:2042	the performance of prepared scaffolds	2028:2064	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	1	19	theme	fabricating	135:145	arg1	nanoparticles					156:168	fabricating monetite nanoparticles	135:168	fabricating monetite nanoparticles impregnated gelatin-based composite scaffold to improve the chemical, mechanical and osteogenic properties	135:275	This study was aimed at fabricating monetite nanoparticles impregnated gelatin-based composite scaffold to improve the chemical, mechanical and osteogenic properties.
34624878	6	20	theme	polymer	1073:1079	arg1	concentration					1081:1093	total polymer concentration	1067:1093	total polymer concentration	1067:1093	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	8	21	theme	body	1376:1379	arg1	SBF					1388:1390	SBF	1388:1390	SBF	1388:1390	Simulated body fluid (SBF) study and alizarin red assays confirmed higher bio-mineralization ability of GM20as compared to that exhibited by GM0.
34624878	8	21	theme	body	1376:1379	arg1	fluid					1381:1385	Simulated body fluid	1366:1385	Simulated body fluid (SBF)	1366:1391	Simulated body fluid (SBF) study and alizarin red assays confirmed higher bio-mineralization ability of GM20as compared to that exhibited by GM0.
34624878	5	22	theme	average	842:848	arg1	size					855:858	The average pore size	838:858	The average pore size of the prepared scaffold	838:883	The average pore size of the prepared scaffold decreased with monetite addition as reflected in values of 210 μm for pure gelatin GM0scaffold and 118 μm registered by GM20scaffold.
34624878	5	23	theme	gelatin	960:966	arg1	GM0scaffold					968:978	pure gelatin GM0scaffold	955:978	pure gelatin GM0scaffold	955:978	The average pore size of the prepared scaffold decreased with monetite addition as reflected in values of 210 μm for pure gelatin GM0scaffold and 118 μm registered by GM20scaffold.
34624878	3	24	from	stability	599:607	arg1	environment					628:638	a physiological environment	612:638	a physiological environment	612:638	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	7	25	theme	composite	1253:1261	arg1	scaffolds					1263:1271	monetite reinforced composite scaffolds	1233:1271	monetite reinforced composite scaffolds	1233:1271	Up to 20 wt% of monetite reinforced composite scaffolds exhibited higher bioactivity as compared to that observed in pure gelatin-based GM0scaffold.
34624878	1	26	theme	gelatin-based	182:194	arg1	scaffold					206:213	gelatin-based composite scaffold	182:213	gelatin-based composite scaffold	182:213	This study was aimed at fabricating monetite nanoparticles impregnated gelatin-based composite scaffold to improve the chemical, mechanical and osteogenic properties.
34624878	6	27	theme	wt	1060:1061	arg1	%					1062:1062	20 wt%	1057:1062	20 wt% of total polymer concentration	1057:1093	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	6	27	theme	wt	1060:1061	arg1	concentration					1081:1093	total polymer concentration	1067:1093	total polymer concentration	1067:1093	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	7	28	theme	reinforced	1242:1251	arg1	scaffolds					1263:1271	monetite reinforced composite scaffolds	1233:1271	monetite reinforced composite scaffolds	1233:1271	Up to 20 wt% of monetite reinforced composite scaffolds exhibited higher bioactivity as compared to that observed in pure gelatin-based GM0scaffold.
34624878	7	29	theme	monetite	1233:1240	arg1	scaffolds					1263:1271	monetite reinforced composite scaffolds	1233:1271	monetite reinforced composite scaffolds	1233:1271	Up to 20 wt% of monetite reinforced composite scaffolds exhibited higher bioactivity as compared to that observed in pure gelatin-based GM0scaffold.
34624878	9	30	theme	higher	1555:1560	arg1	degree					1562:1567	higher degree	1555:1567	higher degree of filopodia and lamellipodia extensions	1555:1608	Human preosteoblast cells (MG-63) revealed higher degree of filopodia and lamellipodia extensions and excellent spreading behavior to anchor with GM20matrix as compared to that onto GM0and GM10.
34624878	9	31	theme	excellent	1614:1622	arg1	behavior					1634:1641	excellent spreading behavior	1614:1641	excellent spreading behavior to anchor	1614:1651	Human preosteoblast cells (MG-63) revealed higher degree of filopodia and lamellipodia extensions and excellent spreading behavior to anchor with GM20matrix as compared to that onto GM0and GM10.
34624878	6	32	theme	scaffolds	1133:1141	arg1	strength					1108:1115	compressive strength	1096:1115	compressive strength of the prepared scaffolds	1096:1141	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	0	33	theme	mechanical	73:82	arg1	properties					99:108	improved mechanical and osteogenic properties	64:108	improved mechanical and osteogenic properties	64:108	Monetite addition into gelatin based freeze-dried scaffolds for improved mechanical and osteogenic properties.
34624878	4	34	theme	microscopy	817:826	arg1	analysis					828:835	field emission scanning electron microscopy analysis	784:835	field emission scanning electron microscopy analysis	784:835	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	9	35	dep	filopodia	1572:1580	arg1	extensions					1599:1608	extensions	1599:1608	extensions	1599:1608	Human preosteoblast cells (MG-63) revealed higher degree of filopodia and lamellipodia extensions and excellent spreading behavior to anchor with GM20matrix as compared to that onto GM0and GM10.
34624878	3	36	theme	glutaraldehyde	465:478	arg1	solution					480:487	0.25 wt% glutaraldehyde solution	456:487	0.25 wt% glutaraldehyde solution	456:487	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	7	37	theme	20	1223:1224	arg1	wt					1226:1227	wt	1226:1227	wt	1226:1227	Up to 20 wt% of monetite reinforced composite scaffolds exhibited higher bioactivity as compared to that observed in pure gelatin-based GM0scaffold.
34624878	3	38	theme	lyophilized	411:421	arg1	scaffolds					423:431	The lyophilized scaffolds	407:431	The lyophilized scaffolds	407:431	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	1	39	theme	monetite	147:154	arg1	nanoparticles					156:168	fabricating monetite nanoparticles	135:168	fabricating monetite nanoparticles impregnated gelatin-based composite scaffold to improve the chemical, mechanical and osteogenic properties	135:275	This study was aimed at fabricating monetite nanoparticles impregnated gelatin-based composite scaffold to improve the chemical, mechanical and osteogenic properties.
34624878	3	40	theme	wt	461:462	arg1	solution					480:487	0.25 wt% glutaraldehyde solution	456:487	0.25 wt% glutaraldehyde solution	456:487	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	6	41	theme	compressive	1096:1106	arg1	strength					1108:1115	compressive strength	1096:1115	compressive strength of the prepared scaffolds	1096:1141	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	8	42	theme	bio-mineralization	1440:1457	arg1	ability					1459:1465	higher bio-mineralization ability	1433:1465	higher bio-mineralization ability of GM20as	1433:1475	Simulated body fluid (SBF) study and alizarin red assays confirmed higher bio-mineralization ability of GM20as compared to that exhibited by GM0.
34624878	10	43	theme	alkaline	1721:1728	arg1	phosphatase					1730:1740	alkaline phosphatase	1721:1740	alkaline phosphatase staining	1721:1749	MTT assay and alkaline phosphatase staining study indicated that MG-63 cells found a more conducive environment to proliferate and subsequently differentiate into osteoblast lineage when exposed to GM20scaffolds rather than to GM0and GM10.
34624878	0	44	theme	based	31:35	arg1	scaffolds					50:58	gelatin based freeze-dried scaffolds	23:58	gelatin based freeze-dried scaffolds for improved mechanical and osteogenic properties	23:108	Monetite addition into gelatin based freeze-dried scaffolds for improved mechanical and osteogenic properties.
34624878	7	45	theme	gelatin-based	1339:1351	arg1	GM0scaffold					1353:1363	pure gelatin-based GM0scaffold	1334:1363	pure gelatin-based GM0scaffold	1334:1363	Up to 20 wt% of monetite reinforced composite scaffolds exhibited higher bioactivity as compared to that observed in pure gelatin-based GM0scaffold.
34624878	7	46	dep	wt	1226:1227	arg1	to					1220:1221	to	1220:1221	to	1220:1221	Up to 20 wt% of monetite reinforced composite scaffolds exhibited higher bioactivity as compared to that observed in pure gelatin-based GM0scaffold.
34624878	0	47	theme	improved	64:71	arg1	properties					99:108	improved mechanical and osteogenic properties	64:108	improved mechanical and osteogenic properties	64:108	Monetite addition into gelatin based freeze-dried scaffolds for improved mechanical and osteogenic properties.
34624878	3	48	theme	porous	539:544	arg1	microstructure					546:559	a three-dimensional (3D) interconnected porous microstructure	499:559	a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment	499:638	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	5	49	theme	scaffold	876:883	arg1	size					855:858	The average pore size	838:858	The average pore size of the prepared scaffold	838:883	The average pore size of the prepared scaffold decreased with monetite addition as reflected in values of 210 μm for pure gelatin GM0scaffold and 118 μm registered by GM20scaffold.
34624878	2	50	contain	containing	350:359	arg1	slurry					343:348	the slurry	339:348	the slurry containing a varying proportion of gelatin and monetite	339:404	Scaffolds were fabricated using a freeze-drying technique of the slurry containing a varying proportion of gelatin and monetite.
34624878	2	50	contain	containing	350:359	arg2	proportion					371:380	a varying proportion	361:380	a varying proportion of gelatin and monetite	361:404	Scaffolds were fabricated using a freeze-drying technique of the slurry containing a varying proportion of gelatin and monetite.
34624878	6	51	theme	gelatin-based	1179:1191	arg1	MPa					1204:1206	pure gelatin-based GM0to 2.43 MPa	1174:1206	pure gelatin-based GM0to 2.43 MPa	1174:1206	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	6	52	from	increase	1022:1029	arg1	content					1043:1049	monetite content	1034:1049	monetite content up to 20 wt% of total polymer concentration	1034:1093	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	3	53	dep	three-dimensional	501:517	arg1	3D					520:521	3D	520:521	3D	520:521	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	4	54	theme	%	679:679	arg1	porosity					681:688	>80% porosity	676:688	>80% porosity	676:688	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	11	55	theme	monetite	1985:1992	arg1	candidate					2092:2100	an efficient candidate	2079:2100	an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites	2079:2170	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	11	55	theme	monetite	1985:1992	arg1	addition					1994:2001	up to 20 wt% monetite addition	1972:2001	up to 20 wt% monetite addition in gelatin	1972:2012	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	10	56	dep	assay	1711:1715	arg1	study					1751:1755	study	1751:1755	study	1751:1755	MTT assay and alkaline phosphatase staining study indicated that MG-63 cells found a more conducive environment to proliferate and subsequently differentiate into osteoblast lineage when exposed to GM20scaffolds rather than to GM0and GM10.
34624878	3	57	theme	mechanical	575:584	arg1	strength					586:593	improved mechanical strength	566:593	improved mechanical strength	566:593	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	5	58	theme	pore	850:853	arg1	size					855:858	The average pore size	838:858	The average pore size of the prepared scaffold	838:883	The average pore size of the prepared scaffold decreased with monetite addition as reflected in values of 210 μm for pure gelatin GM0scaffold and 118 μm registered by GM20scaffold.
34624878	2	59	theme	monetite	397:404	arg1	proportion					371:380	a varying proportion	361:380	a varying proportion of gelatin and monetite	361:404	Scaffolds were fabricated using a freeze-drying technique of the slurry containing a varying proportion of gelatin and monetite.
34624878	4	60	theme	fabricated	645:654	arg1	scaffolds					656:664	The fabricated scaffolds	641:664	The fabricated scaffolds	641:664	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	2	61	theme	gelatin	385:391	arg1	proportion					371:380	a varying proportion	361:380	a varying proportion of gelatin and monetite	361:404	Scaffolds were fabricated using a freeze-drying technique of the slurry containing a varying proportion of gelatin and monetite.
34624878	3	62	from	strength	586:593	arg1	environment					628:638	a physiological environment	612:638	a physiological environment	612:638	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	2	63	theme	freeze-drying	312:324	arg1	technique					326:334	a freeze-drying technique	310:334	a freeze-drying technique of the slurry containing a varying proportion of gelatin and monetite	310:404	Scaffolds were fabricated using a freeze-drying technique of the slurry containing a varying proportion of gelatin and monetite.
34624878	1	64	theme	composite	196:204	arg1	scaffold					206:213	gelatin-based composite scaffold	182:213	gelatin-based composite scaffold	182:213	This study was aimed at fabricating monetite nanoparticles impregnated gelatin-based composite scaffold to improve the chemical, mechanical and osteogenic properties.
34624878	5	65	theme	μm	948:949	arg1	μm					988:989	118 μm	984:989	118 μm	984:989	The average pore size of the prepared scaffold decreased with monetite addition as reflected in values of 210 μm for pure gelatin GM0scaffold and 118 μm registered by GM20scaffold.
34624878	5	65	theme	μm	948:949	arg1	values					934:939	values	934:939	values of 210 μm for pure gelatin GM0scaffold	934:978	The average pore size of the prepared scaffold decreased with monetite addition as reflected in values of 210 μm for pure gelatin GM0scaffold and 118 μm registered by GM20scaffold.
34624878	2	66	theme	slurry	343:348	arg1	technique					326:334	a freeze-drying technique	310:334	a freeze-drying technique of the slurry containing a varying proportion of gelatin and monetite	310:404	Scaffolds were fabricated using a freeze-drying technique of the slurry containing a varying proportion of gelatin and monetite.
34624878	9	67	theme	Human	1512:1516	arg1	MG-63					1539:1543	MG-63	1539:1543	MG-63	1539:1543	Human preosteoblast cells (MG-63) revealed higher degree of filopodia and lamellipodia extensions and excellent spreading behavior to anchor with GM20matrix as compared to that onto GM0and GM10.
34624878	9	67	theme	Human	1512:1516	arg1	cells					1532:1536	Human preosteoblast cells	1512:1536	Human preosteoblast cells (MG-63)	1512:1544	Human preosteoblast cells (MG-63) revealed higher degree of filopodia and lamellipodia extensions and excellent spreading behavior to anchor with GM20matrix as compared to that onto GM0and GM10.
34624878	6	68	theme	monetite	1034:1041	arg1	content					1043:1049	monetite content	1034:1049	monetite content up to 20 wt% of total polymer concentration	1034:1093	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	11	69	dep	repair	2105:2110	arg1	tissues					2132:2138	bone tissues	2127:2138	bone tissues	2127:2138	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	4	70	theme	interconnected	700:713	arg1	distribution					725:736	3D interconnected pore size distribution	697:736	3D interconnected pore size distribution varying between 65 and 270 μm	697:766	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	4	71	contain	possessed	666:674	arg2	porosity					681:688	>80% porosity	676:688	>80% porosity	676:688	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	4	71	contain	possessed	666:674	arg1	scaffolds					656:664	The fabricated scaffolds	641:664	The fabricated scaffolds	641:664	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	4	72	theme	size	720:723	arg1	distribution					725:736	3D interconnected pore size distribution	697:736	3D interconnected pore size distribution varying between 65 and 270 μm	697:766	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	11	73	from	addition	1994:2001	arg1	gelatin					2006:2012	gelatin	2006:2012	gelatin	2006:2012	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	11	74	theme	prepared	2047:2054	arg1	scaffolds					2056:2064	prepared scaffolds	2047:2064	prepared scaffolds	2047:2064	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	3	75	theme	physiological	614:626	arg1	environment					628:638	a physiological environment	612:638	a physiological environment	612:638	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	6	76	theme	concentration	1081:1093	arg1	%					1062:1062	20 wt%	1057:1062	20 wt% of total polymer concentration	1057:1093	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	6	76	theme	concentration	1081:1093	arg1	concentration					1081:1093	total polymer concentration	1067:1093	total polymer concentration	1067:1093	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	11	77	theme	musculoskeletal	2143:2157	arg1	sites					2166:2170	musculoskeletal defect sites	2143:2170	musculoskeletal defect sites	2143:2170	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	4	78	theme	emission	790:797	arg1	microscopy					817:826	field emission scanning electron microscopy	784:826	field emission scanning electron microscopy analysis	784:835	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	7	79	theme	scaffolds	1263:1271	arg1	scaffolds					1263:1271	monetite reinforced composite scaffolds	1233:1271	monetite reinforced composite scaffolds	1233:1271	Up to 20 wt% of monetite reinforced composite scaffolds exhibited higher bioactivity as compared to that observed in pure gelatin-based GM0scaffold.
34624878	7	79	theme	scaffolds	1263:1271	arg1	%					1228:1228	Up to 20 wt%	1217:1228	Up to 20 wt% of monetite reinforced composite scaffolds	1217:1271	Up to 20 wt% of monetite reinforced composite scaffolds exhibited higher bioactivity as compared to that observed in pure gelatin-based GM0scaffold.
34624878	5	80	theme	pure	955:958	arg1	GM0scaffold					968:978	pure gelatin GM0scaffold	955:978	pure gelatin GM0scaffold	955:978	The average pore size of the prepared scaffold decreased with monetite addition as reflected in values of 210 μm for pure gelatin GM0scaffold and 118 μm registered by GM20scaffold.
34624878	6	81	theme	total	1067:1071	arg1	concentration					1081:1093	total polymer concentration	1067:1093	total polymer concentration	1067:1093	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	8	82	theme	Simulated	1366:1374	arg1	SBF					1388:1390	SBF	1388:1390	SBF	1388:1390	Simulated body fluid (SBF) study and alizarin red assays confirmed higher bio-mineralization ability of GM20as compared to that exhibited by GM0.
34624878	8	82	theme	Simulated	1366:1374	arg1	fluid					1381:1385	Simulated body fluid	1366:1385	Simulated body fluid (SBF)	1366:1391	Simulated body fluid (SBF) study and alizarin red assays confirmed higher bio-mineralization ability of GM20as compared to that exhibited by GM0.
34624878	11	83	from	sites	2166:2170	arg1	regenerate					2116:2125	regenerate	2116:2125	regenerate	2116:2125	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	11	83	from	sites	2166:2170	arg1	repair					2105:2110	repair	2105:2110	repair	2105:2110	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	0	84	theme	osteogenic	88:97	arg1	properties					99:108	improved mechanical and osteogenic properties	64:108	improved mechanical and osteogenic properties	64:108	Monetite addition into gelatin based freeze-dried scaffolds for improved mechanical and osteogenic properties.
34624878	9	85	theme	filopodia	1572:1580	arg1	behavior					1634:1641	excellent spreading behavior	1614:1641	excellent spreading behavior to anchor	1614:1651	Human preosteoblast cells (MG-63) revealed higher degree of filopodia and lamellipodia extensions and excellent spreading behavior to anchor with GM20matrix as compared to that onto GM0and GM10.
34624878	9	85	theme	filopodia	1572:1580	arg1	degree					1562:1567	higher degree	1555:1567	higher degree of filopodia and lamellipodia extensions	1555:1608	Human preosteoblast cells (MG-63) revealed higher degree of filopodia and lamellipodia extensions and excellent spreading behavior to anchor with GM20matrix as compared to that onto GM0and GM10.
34624878	8	86	theme	fluid	1381:1385	arg1	study					1393:1397	Simulated body fluid (SBF) study and alizarin red assays	1366:1421	study	1393:1397	Simulated body fluid (SBF) study and alizarin red assays confirmed higher bio-mineralization ability of GM20as compared to that exhibited by GM0.
34624878	9	87	theme	lamellipodia	1586:1597	arg1	behavior					1634:1641	excellent spreading behavior	1614:1641	excellent spreading behavior to anchor	1614:1651	Human preosteoblast cells (MG-63) revealed higher degree of filopodia and lamellipodia extensions and excellent spreading behavior to anchor with GM20matrix as compared to that onto GM0and GM10.
34624878	9	87	theme	lamellipodia	1586:1597	arg1	degree					1562:1567	higher degree	1555:1567	higher degree of filopodia and lamellipodia extensions	1555:1608	Human preosteoblast cells (MG-63) revealed higher degree of filopodia and lamellipodia extensions and excellent spreading behavior to anchor with GM20matrix as compared to that onto GM0and GM10.
34624878	3	88	theme	interconnected	524:537	arg1	microstructure					546:559	a three-dimensional (3D) interconnected porous microstructure	499:559	a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment	499:638	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	7	89	located	observed	1322:1329	arg1	GM0scaffold					1353:1363	pure gelatin-based GM0scaffold	1334:1363	pure gelatin-based GM0scaffold	1334:1363	Up to 20 wt% of monetite reinforced composite scaffolds exhibited higher bioactivity as compared to that observed in pure gelatin-based GM0scaffold.
34624878	7	89	located	observed	1322:1329	arg2	that					1317:1320	that	1317:1320	that	1317:1320	Up to 20 wt% of monetite reinforced composite scaffolds exhibited higher bioactivity as compared to that observed in pure gelatin-based GM0scaffold.
34624878	9	90	theme	preosteoblast	1518:1530	arg1	MG-63					1539:1543	MG-63	1539:1543	MG-63	1539:1543	Human preosteoblast cells (MG-63) revealed higher degree of filopodia and lamellipodia extensions and excellent spreading behavior to anchor with GM20matrix as compared to that onto GM0and GM10.
34624878	9	90	theme	preosteoblast	1518:1530	arg1	cells					1532:1536	Human preosteoblast cells	1512:1536	Human preosteoblast cells (MG-63)	1512:1544	Human preosteoblast cells (MG-63) revealed higher degree of filopodia and lamellipodia extensions and excellent spreading behavior to anchor with GM20matrix as compared to that onto GM0and GM10.
34624878	10	91	theme	MTT	1707:1709	arg1	assay					1711:1715	MTT assay	1707:1715	MTT assay	1707:1715	MTT assay and alkaline phosphatase staining study indicated that MG-63 cells found a more conducive environment to proliferate and subsequently differentiate into osteoblast lineage when exposed to GM20scaffolds rather than to GM0and GM10.
34624878	4	92	from	analysis	828:835	arg1	evident					771:777	evident	771:777	evident	771:777	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	9	93	theme	spreading	1624:1632	arg1	behavior					1634:1641	excellent spreading behavior	1614:1641	excellent spreading behavior to anchor	1614:1651	Human preosteoblast cells (MG-63) revealed higher degree of filopodia and lamellipodia extensions and excellent spreading behavior to anchor with GM20matrix as compared to that onto GM0and GM10.
34624878	6	94	theme	prepared	1124:1131	arg1	scaffolds					1133:1141	the prepared scaffolds	1120:1141	the prepared scaffolds	1120:1141	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	4	95	theme	electron	808:815	arg1	microscopy					817:826	field emission scanning electron microscopy	784:826	field emission scanning electron microscopy analysis	784:835	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
34624878	11	96	theme	efficient	2082:2090	arg1	candidate					2092:2100	an efficient candidate	2079:2100	an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites	2079:2170	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	11	96	theme	efficient	2082:2090	arg1	addition					1994:2001	up to 20 wt% monetite addition	1972:2001	up to 20 wt% monetite addition in gelatin	1972:2012	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	0	97	theme	gelatin	23:29	arg1	scaffolds					50:58	gelatin based freeze-dried scaffolds	23:58	gelatin based freeze-dried scaffolds for improved mechanical and osteogenic properties	23:108	Monetite addition into gelatin based freeze-dried scaffolds for improved mechanical and osteogenic properties.
34624878	10	98	theme	phosphatase	1730:1740	arg1	staining					1742:1749	alkaline phosphatase staining	1721:1749	alkaline phosphatase staining	1721:1749	MTT assay and alkaline phosphatase staining study indicated that MG-63 cells found a more conducive environment to proliferate and subsequently differentiate into osteoblast lineage when exposed to GM20scaffolds rather than to GM0and GM10.
34624878	0	99	theme	freeze-dried	37:48	arg1	scaffolds					50:58	gelatin based freeze-dried scaffolds	23:58	gelatin based freeze-dried scaffolds for improved mechanical and osteogenic properties	23:108	Monetite addition into gelatin based freeze-dried scaffolds for improved mechanical and osteogenic properties.
34624878	7	100	theme	pure	1334:1337	arg1	GM0scaffold					1353:1363	pure gelatin-based GM0scaffold	1334:1363	pure gelatin-based GM0scaffold	1334:1363	Up to 20 wt% of monetite reinforced composite scaffolds exhibited higher bioactivity as compared to that observed in pure gelatin-based GM0scaffold.
34624878	3	101	theme	%	463:463	arg1	solution					480:487	0.25 wt% glutaraldehyde solution	456:487	0.25 wt% glutaraldehyde solution	456:487	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	10	102	theme	GM0and	1934:1939	arg1	GM10					1941:1944	GM0and GM10	1934:1944	GM0and GM10	1934:1944	MTT assay and alkaline phosphatase staining study indicated that MG-63 cells found a more conducive environment to proliferate and subsequently differentiate into osteoblast lineage when exposed to GM20scaffolds rather than to GM0and GM10.
34624878	8	103	theme	higher	1433:1438	arg1	ability					1459:1465	higher bio-mineralization ability	1433:1465	higher bio-mineralization ability of GM20as	1433:1475	Simulated body fluid (SBF) study and alizarin red assays confirmed higher bio-mineralization ability of GM20as compared to that exhibited by GM0.
34624878	3	104	theme	three-dimensional	501:517	arg1	microstructure					546:559	a three-dimensional (3D) interconnected porous microstructure	499:559	a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment	499:638	The lyophilized scaffolds were cross-linked with 0.25 wt% glutaraldehyde solution to obtain a three-dimensional (3D) interconnected porous microstructure with improved mechanical strength and stability in a physiological environment.
34624878	5	105	theme	prepared	867:874	arg1	scaffold					876:883	the prepared scaffold	863:883	the prepared scaffold	863:883	The average pore size of the prepared scaffold decreased with monetite addition as reflected in values of 210 μm for pure gelatin GM0scaffold and 118 μm registered by GM20scaffold.
34624878	11	106	dep	20	1978:1979	arg1	to					1975:1976	to	1975:1976	to	1975:1976	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	6	107	theme	GM0to	1193:1197	arg1	MPa					1204:1206	pure gelatin-based GM0to 2.43 MPa	1174:1206	pure gelatin-based GM0to 2.43 MPa	1174:1206	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	6	108	theme	pure	1174:1177	arg1	MPa					1204:1206	pure gelatin-based GM0to 2.43 MPa	1174:1206	pure gelatin-based GM0to 2.43 MPa	1174:1206	On increase in monetite content up to 20 wt% of total polymer concentration, compressive strength of the prepared scaffolds was increased from 0.92 MPa in pure gelatin-based GM0to 2.43 MPa in GM20.
34624878	8	109	theme	GM20as	1470:1475	arg1	ability					1459:1465	higher bio-mineralization ability	1433:1465	higher bio-mineralization ability of GM20as	1433:1475	Simulated body fluid (SBF) study and alizarin red assays confirmed higher bio-mineralization ability of GM20as compared to that exhibited by GM0.
34624878	2	110	theme	varying	363:369	arg1	proportion					371:380	a varying proportion	361:380	a varying proportion of gelatin and monetite	361:404	Scaffolds were fabricated using a freeze-drying technique of the slurry containing a varying proportion of gelatin and monetite.
34624878	1	111	theme	osteogenic	255:264	arg1	properties					266:275	the chemical, mechanical and osteogenic properties	226:275	the chemical, mechanical and osteogenic properties	226:275	This study was aimed at fabricating monetite nanoparticles impregnated gelatin-based composite scaffold to improve the chemical, mechanical and osteogenic properties.
34624878	11	112	theme	wt	1981:1982	arg1	candidate					2092:2100	an efficient candidate	2079:2100	an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites	2079:2170	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	11	112	theme	wt	1981:1982	arg1	addition					1994:2001	up to 20 wt% monetite addition	1972:2001	up to 20 wt% monetite addition in gelatin	1972:2012	This study revealed that up to 20 wt% monetite addition in gelatin could improve the performance of prepared scaffolds and serve as an efficient candidate to repair and regenerate bone tissues at musculoskeletal defect sites.
34624878	4	113	theme	3D	697:698	arg1	distribution					725:736	3D interconnected pore size distribution	697:736	3D interconnected pore size distribution varying between 65 and 270 μm	697:766	The fabricated scaffolds possessed >80% porosity having 3D interconnected pore size distribution varying between 65 and 270 μm as evident from field emission scanning electron microscopy analysis.
33652073	6	0	dep	8-fold	1207:1212	arg1	lower					1214:1218	lower	1214:1218	lower	1214:1218	Evaluation of binding kinetics by SPR demonstrated that PlyPH binding was particularly sensitive to medium composition, with 8-fold lower association and 3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS.
33652073	3	1	theme	complex	538:544	arg1	media					546:550	complex media	538:550	complex media	538:550	Lst and PlyPH show reduced activity in the presence of bacterial growth-supporting conditions, such as complex media.
33652073	7	2	theme	cereus	1429:1434	arg1	populations					1397:1407	the binding-dependent fluorescent populations	1363:1407	the binding-dependent fluorescent populations of S. aureus and B. cereus	1363:1434	Flow cytometry studies indicated a decrease in the binding-dependent fluorescent populations of S. aureus and B. cereus, for lysostaphin binding domain and PlyPH binding domain, respectively, in TSB compared to PBS.
33652073	7	3	theme	fluorescent	1385:1395	arg1	populations					1397:1407	the binding-dependent fluorescent populations	1363:1407	the binding-dependent fluorescent populations of S. aureus and B. cereus	1363:1434	Flow cytometry studies indicated a decrease in the binding-dependent fluorescent populations of S. aureus and B. cereus, for lysostaphin binding domain and PlyPH binding domain, respectively, in TSB compared to PBS.
33652073	8	4	from	activity	1709:1716	arg1	media					1741:1745	more complex growth media	1721:1745	more complex growth media	1721:1745	Enzyme binding behavior was consistent with the enzymes' catalytic activity in the three media, thereby suggesting that compromised enzyme binding could be responsible for poor activity in more complex growth media.
33652073	8	5	theme	compromised	1652:1662	arg1	binding					1671:1677	compromised enzyme binding	1652:1677	compromised enzyme binding	1652:1677	Enzyme binding behavior was consistent with the enzymes' catalytic activity in the three media, thereby suggesting that compromised enzyme binding could be responsible for poor activity in more complex growth media.
33652073	5	6	theme	target	846:851	arg1	bacteria					853:860	target bacteria	846:860	target bacteria	846:860	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	6	7	theme	binding	1096:1102	arg1	kinetics					1104:1111	binding kinetics	1096:1111	binding kinetics	1096:1111	Evaluation of binding kinetics by SPR demonstrated that PlyPH binding was particularly sensitive to medium composition, with 8-fold lower association and 3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS.
33652073	4	8	theme	antimicrobial	672:684	arg1	applications					686:697	antimicrobial applications	672:697	antimicrobial applications in the food industry	672:718	Here, we hypothesize that Lst and PlyPH bind poorly to their targets in growth media, which may influence their use in antimicrobial applications in the food industry, as therapeutics, and for control of microbial communities.
33652073	2	9	theme	catalytic	328:336	arg1	domain					338:343	an N-terminal catalytic domain	314:343	an N-terminal catalytic domain	314:343	Both enzymes possess an N-terminal catalytic domain and C-terminal binding domain, with the latter conferring significant enzyme specificity.
33652073	8	10	with	consistent	1560:1569	arg1	activity					1599:1606	the enzymes' catalytic activity	1576:1606	the enzymes' catalytic activity in the three media	1576:1625	Enzyme binding behavior was consistent with the enzymes' catalytic activity in the three media, thereby suggesting that compromised enzyme binding could be responsible for poor activity in more complex growth media.
33652073	5	11	theme	PlyPH	821:825	arg1	domains					835:841	isolated Lst and PlyPH binding domains	804:841	isolated Lst and PlyPH binding domains	804:841	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	7	12	theme	cytometry	1321:1329	arg1	studies					1331:1337	Flow cytometry studies	1316:1337	Flow cytometry studies	1316:1337	Flow cytometry studies indicated a decrease in the binding-dependent fluorescent populations of S. aureus and B. cereus, for lysostaphin binding domain and PlyPH binding domain, respectively, in TSB compared to PBS.
33652073	5	13	theme	isolated	804:811	arg1	domains					835:841	isolated Lst and PlyPH binding domains	804:841	isolated Lst and PlyPH binding domains	804:841	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	14	theme	domains	835:841	arg1	binding					793:799	binding	793:799	binding of isolated Lst and PlyPH binding domains to target bacteria	793:860	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	6	15	theme	rate	1264:1267	arg1	constants					1269:1277	3.4-fold lower dissociation rate constants	1236:1277	3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS	1236:1313	Evaluation of binding kinetics by SPR demonstrated that PlyPH binding was particularly sensitive to medium composition, with 8-fold lower association and 3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS.
33652073	5	16	theme	undefined	996:1004	arg1	medium					1014:1019	undefined complex medium	996:1019	undefined complex medium (TSB)	996:1025	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	16	theme	undefined	996:1004	arg1	media					923:927	three increasingly complex media	896:927	three increasingly complex media - phosphate buffered saline (PBS)	896:961	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	16	theme	undefined	996:1004	arg1	TSB					1022:1024	TSB	1022:1024	TSB	1022:1024	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	6	17	theme	lower	1245:1249	arg1	constants					1269:1277	3.4-fold lower dissociation rate constants	1236:1277	3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS	1236:1313	Evaluation of binding kinetics by SPR demonstrated that PlyPH binding was particularly sensitive to medium composition, with 8-fold lower association and 3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS.
33652073	5	18	theme	complex	915:921	arg1	medium					1014:1019	undefined complex medium	996:1019	undefined complex medium (TSB)	996:1025	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	18	theme	complex	915:921	arg1	media					923:927	three increasingly complex media	896:927	three increasingly complex media - phosphate buffered saline (PBS)	896:961	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	18	theme	complex	915:921	arg1	medium					979:984	defined growth medium	964:984	defined growth medium (AAM)	964:990	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	7	19	from	decrease	1351:1358	arg1	TSB					1511:1513	TSB	1511:1513	TSB	1511:1513	Flow cytometry studies indicated a decrease in the binding-dependent fluorescent populations of S. aureus and B. cereus, for lysostaphin binding domain and PlyPH binding domain, respectively, in TSB compared to PBS.
33652073	7	19	from	decrease	1351:1358	arg1	populations					1397:1407	the binding-dependent fluorescent populations	1363:1407	the binding-dependent fluorescent populations of S. aureus and B. cereus	1363:1434	Flow cytometry studies indicated a decrease in the binding-dependent fluorescent populations of S. aureus and B. cereus, for lysostaphin binding domain and PlyPH binding domain, respectively, in TSB compared to PBS.
33652073	6	20	theme	PlyPH	1138:1142	arg1	binding					1144:1150	PlyPH binding	1138:1150	PlyPH binding	1138:1150	Evaluation of binding kinetics by SPR demonstrated that PlyPH binding was particularly sensitive to medium composition, with 8-fold lower association and 3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS.
33652073	5	21	theme	Lst	813:815	arg1	domains					835:841	isolated Lst and PlyPH binding domains	804:841	isolated Lst and PlyPH binding domains	804:841	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	8	22	theme	growth	1734:1739	arg1	media					1741:1745	more complex growth media	1721:1745	more complex growth media	1721:1745	Enzyme binding behavior was consistent with the enzymes' catalytic activity in the three media, thereby suggesting that compromised enzyme binding could be responsible for poor activity in more complex growth media.
33652073	1	23	theme	endolysin	131:139	arg1	lysostaphin					109:119	The bacteriolysin lysostaphin	91:119	The bacteriolysin lysostaphin (Lst)	91:125	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	1	23	theme	endolysin	131:139	arg1	enzymes					172:178	potent modular lytic enzymes	151:178	potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively	151:290	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	1	23	theme	endolysin	131:139	arg1	PlyPH					141:145	endolysin PlyPH	131:145	endolysin PlyPH	131:145	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	4	24	theme	food	706:709	arg1	industry					711:718	the food industry	702:718	the food industry	702:718	Here, we hypothesize that Lst and PlyPH bind poorly to their targets in growth media, which may influence their use in antimicrobial applications in the food industry, as therapeutics, and for control of microbial communities.
33652073	0	25	theme	wall	71:74	arg1	enzymes					82:88	cell wall lytic enzymes	66:88	cell wall lytic enzymes	66:88	Influence of bacterial culture medium on peptidoglycan binding of cell wall lytic enzymes.
33652073	5	26	theme	flow	1066:1069	arg1	cytometry					1071:1079	flow cytometry	1066:1079	flow cytometry	1066:1079	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	0	27	from	Influence	0:8	arg1	binding					55:61	peptidoglycan binding	41:61	peptidoglycan binding of cell wall lytic enzymes	41:88	Influence of bacterial culture medium on peptidoglycan binding of cell wall lytic enzymes.
33652073	4	28	theme	microbial	757:765	arg1	communities					767:777	microbial communities	757:777	microbial communities	757:777	Here, we hypothesize that Lst and PlyPH bind poorly to their targets in growth media, which may influence their use in antimicrobial applications in the food industry, as therapeutics, and for control of microbial communities.
33652073	5	29	theme	buffered	941:948	arg1	PBS					958:960	PBS	958:960	PBS	958:960	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	29	theme	buffered	941:948	arg1	saline					950:955	phosphate buffered saline	931:955	three increasingly complex media - phosphate buffered saline (PBS)	896:961	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	0	30	theme	enzymes	82:88	arg1	binding					55:61	peptidoglycan binding	41:61	peptidoglycan binding of cell wall lytic enzymes	41:88	Influence of bacterial culture medium on peptidoglycan binding of cell wall lytic enzymes.
33652073	5	31	theme	plasmon	1038:1044	arg1	SPR					1057:1059	SPR	1057:1059	SPR	1057:1059	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	31	theme	plasmon	1038:1044	arg1	resonance					1046:1054	surface plasmon resonance	1030:1054	surface plasmon resonance (SPR)	1030:1060	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	2	32	theme	significant	403:413	arg1	specificity					422:432	significant enzyme specificity	403:432	significant enzyme specificity	403:432	Both enzymes possess an N-terminal catalytic domain and C-terminal binding domain, with the latter conferring significant enzyme specificity.
33652073	0	33	theme	bacterial	13:21	arg1	medium					31:36	bacterial culture medium	13:36	bacterial culture medium	13:36	Influence of bacterial culture medium on peptidoglycan binding of cell wall lytic enzymes.
33652073	1	34	theme	bacteriolysin	95:107	arg1	Lst					122:124	Lst	122:124	Lst	122:124	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	1	34	theme	bacteriolysin	95:107	arg1	lysostaphin					109:119	The bacteriolysin lysostaphin	91:119	The bacteriolysin lysostaphin (Lst)	91:125	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	1	34	theme	bacteriolysin	95:107	arg1	enzymes					172:178	potent modular lytic enzymes	151:178	potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively	151:290	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	1	34	theme	bacteriolysin	95:107	arg1	PlyPH					141:145	endolysin PlyPH	131:145	endolysin PlyPH	131:145	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	0	35	theme	medium	31:36	arg1	Influence					0:8	Influence	0:8	Influence of bacterial culture medium on peptidoglycan binding of cell wall lytic enzymes.	0:89	Influence of bacterial culture medium on peptidoglycan binding of cell wall lytic enzymes.
33652073	7	36	theme	PlyPH	1472:1476	arg1	domain					1486:1491	PlyPH binding domain	1472:1491	PlyPH binding domain	1472:1491	Flow cytometry studies indicated a decrease in the binding-dependent fluorescent populations of S. aureus and B. cereus, for lysostaphin binding domain and PlyPH binding domain, respectively, in TSB compared to PBS.
33652073	0	37	theme	peptidoglycan	41:53	arg1	binding					55:61	peptidoglycan binding	41:61	peptidoglycan binding of cell wall lytic enzymes	41:88	Influence of bacterial culture medium on peptidoglycan binding of cell wall lytic enzymes.
33652073	6	38	from	constants	1269:1277	arg1	TSB					1295:1297	TSB	1295:1297	TSB compared to PBS	1295:1313	Evaluation of binding kinetics by SPR demonstrated that PlyPH binding was particularly sensitive to medium composition, with 8-fold lower association and 3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS.
33652073	1	39	with	enzymes	172:178	arg1	activity					185:192	activity	185:192	activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively	185:290	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	2	40	theme	C-terminal	349:358	arg1	domain					368:373	C-terminal binding domain	349:373	C-terminal binding domain	349:373	Both enzymes possess an N-terminal catalytic domain and C-terminal binding domain, with the latter conferring significant enzyme specificity.
33652073	6	41	from	association	1220:1230	arg1	TSB					1295:1297	TSB	1295:1297	TSB compared to PBS	1295:1313	Evaluation of binding kinetics by SPR demonstrated that PlyPH binding was particularly sensitive to medium composition, with 8-fold lower association and 3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS.
33652073	6	42	theme	kinetics	1104:1111	arg1	Evaluation					1082:1091	Evaluation	1082:1091	Evaluation of binding kinetics by SPR	1082:1118	Evaluation of binding kinetics by SPR demonstrated that PlyPH binding was particularly sensitive to medium composition, with 8-fold lower association and 3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS.
33652073	7	43	theme	lysostaphin	1441:1451	arg1	domain					1461:1466	lysostaphin binding domain	1441:1466	lysostaphin binding domain	1441:1466	Flow cytometry studies indicated a decrease in the binding-dependent fluorescent populations of S. aureus and B. cereus, for lysostaphin binding domain and PlyPH binding domain, respectively, in TSB compared to PBS.
33652073	5	44	theme	defined	964:970	arg1	AAM					987:989	AAM	987:989	AAM	987:989	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	44	theme	defined	964:970	arg1	media					923:927	three increasingly complex media	896:927	three increasingly complex media - phosphate buffered saline (PBS)	896:961	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	44	theme	defined	964:970	arg1	medium					979:984	defined growth medium	964:984	defined growth medium (AAM)	964:990	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	4	45	from	use	665:667	arg1	applications					686:697	antimicrobial applications	672:697	antimicrobial applications in the food industry	672:718	Here, we hypothesize that Lst and PlyPH bind poorly to their targets in growth media, which may influence their use in antimicrobial applications in the food industry, as therapeutics, and for control of microbial communities.
33652073	1	46	theme	modular	158:164	arg1	lysostaphin					109:119	The bacteriolysin lysostaphin	91:119	The bacteriolysin lysostaphin (Lst)	91:125	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	1	46	theme	modular	158:164	arg1	enzymes					172:178	potent modular lytic enzymes	151:178	potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively	151:290	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	1	46	theme	modular	158:164	arg1	PlyPH					141:145	endolysin PlyPH	131:145	endolysin PlyPH	131:145	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	4	47	theme	growth	625:630	arg1	media					632:636	growth media	625:636	growth media	625:636	Here, we hypothesize that Lst and PlyPH bind poorly to their targets in growth media, which may influence their use in antimicrobial applications in the food industry, as therapeutics, and for control of microbial communities.
33652073	4	48	from	applications	686:697	arg1	industry					711:718	the food industry	702:718	the food industry	702:718	Here, we hypothesize that Lst and PlyPH bind poorly to their targets in growth media, which may influence their use in antimicrobial applications in the food industry, as therapeutics, and for control of microbial communities.
33652073	7	49	theme	aureus	1415:1420	arg1	populations					1397:1407	the binding-dependent fluorescent populations	1363:1407	the binding-dependent fluorescent populations of S. aureus and B. cereus	1363:1434	Flow cytometry studies indicated a decrease in the binding-dependent fluorescent populations of S. aureus and B. cereus, for lysostaphin binding domain and PlyPH binding domain, respectively, in TSB compared to PBS.
33652073	5	50	dep	media	923:927	arg1	PBS					958:960	PBS	958:960	PBS	958:960	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	50	dep	media	923:927	arg1	saline					950:955	phosphate buffered saline	931:955	three increasingly complex media - phosphate buffered saline (PBS)	896:961	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	6	51	theme	8-fold	1207:1212	arg1	association					1220:1230	8-fold lower association	1207:1230	8-fold lower association	1207:1230	Evaluation of binding kinetics by SPR demonstrated that PlyPH binding was particularly sensitive to medium composition, with 8-fold lower association and 3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS.
33652073	1	52	theme	potent	151:156	arg1	lysostaphin					109:119	The bacteriolysin lysostaphin	91:119	The bacteriolysin lysostaphin (Lst)	91:125	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	1	52	theme	potent	151:156	arg1	enzymes					172:178	potent modular lytic enzymes	151:178	potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively	151:290	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	1	52	theme	potent	151:156	arg1	PlyPH					141:145	endolysin PlyPH	131:145	endolysin PlyPH	131:145	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	7	53	theme	binding-dependent	1367:1383	arg1	populations					1397:1407	the binding-dependent fluorescent populations	1363:1407	the binding-dependent fluorescent populations of S. aureus and B. cereus	1363:1434	Flow cytometry studies indicated a decrease in the binding-dependent fluorescent populations of S. aureus and B. cereus, for lysostaphin binding domain and PlyPH binding domain, respectively, in TSB compared to PBS.
33652073	4	54	from	targets	614:620	arg1	media					632:636	growth media	625:636	growth media	625:636	Here, we hypothesize that Lst and PlyPH bind poorly to their targets in growth media, which may influence their use in antimicrobial applications in the food industry, as therapeutics, and for control of microbial communities.
33652073	1	55	theme	lytic	166:170	arg1	lysostaphin					109:119	The bacteriolysin lysostaphin	91:119	The bacteriolysin lysostaphin (Lst)	91:125	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	1	55	theme	lytic	166:170	arg1	enzymes					172:178	potent modular lytic enzymes	151:178	potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively	151:290	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	1	55	theme	lytic	166:170	arg1	PlyPH					141:145	endolysin PlyPH	131:145	endolysin PlyPH	131:145	The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with activity against clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively.
33652073	2	56	theme	N-terminal	317:326	arg1	domain					338:343	an N-terminal catalytic domain	314:343	an N-terminal catalytic domain	314:343	Both enzymes possess an N-terminal catalytic domain and C-terminal binding domain, with the latter conferring significant enzyme specificity.
33652073	8	57	theme	enzyme	1664:1669	arg1	binding					1671:1677	compromised enzyme binding	1652:1677	compromised enzyme binding	1652:1677	Enzyme binding behavior was consistent with the enzymes' catalytic activity in the three media, thereby suggesting that compromised enzyme binding could be responsible for poor activity in more complex growth media.
33652073	5	58	theme	binding	827:833	arg1	domains					835:841	isolated Lst and PlyPH binding domains	804:841	isolated Lst and PlyPH binding domains	804:841	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	59	theme	surface	1030:1036	arg1	SPR					1057:1059	SPR	1057:1059	SPR	1057:1059	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	59	theme	surface	1030:1036	arg1	resonance					1046:1054	surface plasmon resonance	1030:1054	surface plasmon resonance (SPR)	1030:1060	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	7	60	theme	Flow	1316:1319	arg1	studies					1331:1337	Flow cytometry studies	1316:1337	Flow cytometry studies	1316:1337	Flow cytometry studies indicated a decrease in the binding-dependent fluorescent populations of S. aureus and B. cereus, for lysostaphin binding domain and PlyPH binding domain, respectively, in TSB compared to PBS.
33652073	6	61	theme	dissociation	1251:1262	arg1	constants					1269:1277	3.4-fold lower dissociation rate constants	1236:1277	3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS	1236:1313	Evaluation of binding kinetics by SPR demonstrated that PlyPH binding was particularly sensitive to medium composition, with 8-fold lower association and 3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS.
33652073	5	62	theme	complex	1006:1012	arg1	medium					1014:1019	undefined complex medium	996:1019	undefined complex medium (TSB)	996:1025	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	62	theme	complex	1006:1012	arg1	media					923:927	three increasingly complex media	896:927	three increasingly complex media - phosphate buffered saline (PBS)	896:961	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	62	theme	complex	1006:1012	arg1	TSB					1022:1024	TSB	1022:1024	TSB	1022:1024	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	8	63	theme	poor	1704:1707	arg1	activity					1709:1716	poor activity	1704:1716	poor activity in more complex growth media	1704:1745	Enzyme binding behavior was consistent with the enzymes' catalytic activity in the three media, thereby suggesting that compromised enzyme binding could be responsible for poor activity in more complex growth media.
33652073	6	64	with	sensitive	1169:1177	arg1	association					1220:1230	8-fold lower association	1207:1230	8-fold lower association	1207:1230	Evaluation of binding kinetics by SPR demonstrated that PlyPH binding was particularly sensitive to medium composition, with 8-fold lower association and 3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS.
33652073	6	64	with	sensitive	1169:1177	arg1	constants					1269:1277	3.4-fold lower dissociation rate constants	1236:1277	3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS	1236:1313	Evaluation of binding kinetics by SPR demonstrated that PlyPH binding was particularly sensitive to medium composition, with 8-fold lower association and 3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS.
33652073	3	65	theme	growth-supporting	500:516	arg1	media					546:550	complex media	538:550	complex media	538:550	Lst and PlyPH show reduced activity in the presence of bacterial growth-supporting conditions, such as complex media.
33652073	3	65	theme	growth-supporting	500:516	arg1	conditions					518:527	bacterial growth-supporting conditions	490:527	bacterial growth-supporting conditions	490:527	Lst and PlyPH show reduced activity in the presence of bacterial growth-supporting conditions, such as complex media.
33652073	0	66	theme	cell	66:69	arg1	enzymes					82:88	cell wall lytic enzymes	66:88	cell wall lytic enzymes	66:88	Influence of bacterial culture medium on peptidoglycan binding of cell wall lytic enzymes.
33652073	8	67	theme	Enzyme	1532:1537	arg1	behavior					1547:1554	Enzyme binding behavior	1532:1554	Enzyme binding behavior	1532:1554	Enzyme binding behavior was consistent with the enzymes' catalytic activity in the three media, thereby suggesting that compromised enzyme binding could be responsible for poor activity in more complex growth media.
33652073	0	68	theme	lytic	76:80	arg1	enzymes					82:88	cell wall lytic enzymes	66:88	cell wall lytic enzymes	66:88	Influence of bacterial culture medium on peptidoglycan binding of cell wall lytic enzymes.
33652073	8	69	theme	complex	1726:1732	arg1	media					1741:1745	more complex growth media	1721:1745	more complex growth media	1721:1745	Enzyme binding behavior was consistent with the enzymes' catalytic activity in the three media, thereby suggesting that compromised enzyme binding could be responsible for poor activity in more complex growth media.
33652073	8	70	from	activity	1599:1606	arg1	media					1621:1625	the three media	1611:1625	the three media	1611:1625	Enzyme binding behavior was consistent with the enzymes' catalytic activity in the three media, thereby suggesting that compromised enzyme binding could be responsible for poor activity in more complex growth media.
33652073	4	71	theme	communities	767:777	arg1	control					746:752	control	746:752	control of microbial communities	746:777	Here, we hypothesize that Lst and PlyPH bind poorly to their targets in growth media, which may influence their use in antimicrobial applications in the food industry, as therapeutics, and for control of microbial communities.
33652073	2	72	theme	enzyme	415:420	arg1	specificity					422:432	significant enzyme specificity	403:432	significant enzyme specificity	403:432	Both enzymes possess an N-terminal catalytic domain and C-terminal binding domain, with the latter conferring significant enzyme specificity.
33652073	5	73	theme	media	923:927	arg1	presence					884:891	the presence	880:891	the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB)	880:1025	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	3	74	theme	reduced	454:460	arg1	activity					462:469	reduced activity	454:469	reduced activity in the presence of bacterial growth-supporting conditions, such as complex media	454:550	Lst and PlyPH show reduced activity in the presence of bacterial growth-supporting conditions, such as complex media.
33652073	0	75	theme	culture	23:29	arg1	medium					31:36	bacterial culture medium	13:36	bacterial culture medium	13:36	Influence of bacterial culture medium on peptidoglycan binding of cell wall lytic enzymes.
33652073	5	76	theme	phosphate	931:939	arg1	PBS					958:960	PBS	958:960	PBS	958:960	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	76	theme	phosphate	931:939	arg1	saline					950:955	phosphate buffered saline	931:955	three increasingly complex media - phosphate buffered saline (PBS)	896:961	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	6	77	theme	medium	1182:1187	arg1	composition					1189:1199	medium composition	1182:1199	medium composition	1182:1199	Evaluation of binding kinetics by SPR demonstrated that PlyPH binding was particularly sensitive to medium composition, with 8-fold lower association and 3.4-fold lower dissociation rate constants to B. cereus in TSB compared to PBS.
33652073	3	78	theme	bacterial	490:498	arg1	media					546:550	complex media	538:550	complex media	538:550	Lst and PlyPH show reduced activity in the presence of bacterial growth-supporting conditions, such as complex media.
33652073	3	78	theme	bacterial	490:498	arg1	conditions					518:527	bacterial growth-supporting conditions	490:527	bacterial growth-supporting conditions	490:527	Lst and PlyPH show reduced activity in the presence of bacterial growth-supporting conditions, such as complex media.
33652073	2	79	contain	possess	306:312	arg1	enzymes					298:304	Both enzymes	293:304	Both enzymes	293:304	Both enzymes possess an N-terminal catalytic domain and C-terminal binding domain, with the latter conferring significant enzyme specificity.
33652073	2	79	contain	possess	306:312	arg2	domain					338:343	an N-terminal catalytic domain	314:343	an N-terminal catalytic domain	314:343	Both enzymes possess an N-terminal catalytic domain and C-terminal binding domain, with the latter conferring significant enzyme specificity.
33652073	2	79	contain	possess	306:312	arg2	domain					368:373	C-terminal binding domain	349:373	C-terminal binding domain	349:373	Both enzymes possess an N-terminal catalytic domain and C-terminal binding domain, with the latter conferring significant enzyme specificity.
33652073	7	80	theme	binding	1478:1484	arg1	domain					1486:1491	PlyPH binding domain	1472:1491	PlyPH binding domain	1472:1491	Flow cytometry studies indicated a decrease in the binding-dependent fluorescent populations of S. aureus and B. cereus, for lysostaphin binding domain and PlyPH binding domain, respectively, in TSB compared to PBS.
33652073	2	81	theme	binding	360:366	arg1	domain					368:373	C-terminal binding domain	349:373	C-terminal binding domain	349:373	Both enzymes possess an N-terminal catalytic domain and C-terminal binding domain, with the latter conferring significant enzyme specificity.
33652073	8	82	theme	catalytic	1589:1597	arg1	activity					1599:1606	the enzymes' catalytic activity	1576:1606	the enzymes' catalytic activity in the three media	1576:1625	Enzyme binding behavior was consistent with the enzymes' catalytic activity in the three media, thereby suggesting that compromised enzyme binding could be responsible for poor activity in more complex growth media.
33652073	8	83	theme	binding	1539:1545	arg1	behavior					1547:1554	Enzyme binding behavior	1532:1554	Enzyme binding behavior	1532:1554	Enzyme binding behavior was consistent with the enzymes' catalytic activity in the three media, thereby suggesting that compromised enzyme binding could be responsible for poor activity in more complex growth media.
33652073	3	84	theme	conditions	518:527	arg1	presence					478:485	the presence	474:485	the presence of bacterial growth-supporting conditions, such as complex media	474:550	Lst and PlyPH show reduced activity in the presence of bacterial growth-supporting conditions, such as complex media.
33652073	7	85	theme	binding	1453:1459	arg1	domain					1461:1466	lysostaphin binding domain	1441:1466	lysostaphin binding domain	1441:1466	Flow cytometry studies indicated a decrease in the binding-dependent fluorescent populations of S. aureus and B. cereus, for lysostaphin binding domain and PlyPH binding domain, respectively, in TSB compared to PBS.
33652073	5	86	theme	growth	972:977	arg1	AAM					987:989	AAM	987:989	AAM	987:989	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	86	theme	growth	972:977	arg1	media					923:927	three increasingly complex media	896:927	three increasingly complex media - phosphate buffered saline (PBS)	896:961	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	5	86	theme	growth	972:977	arg1	medium					979:984	defined growth medium	964:984	defined growth medium (AAM)	964:990	To this end, binding of isolated Lst and PlyPH binding domains to target bacteria was quantified in the presence of three increasingly complex media - phosphate buffered saline (PBS), defined growth medium (AAM) and undefined complex medium (TSB) by surface plasmon resonance (SPR) and flow cytometry.
33652073	3	87	from	activity	462:469	arg1	presence					478:485	the presence	474:485	the presence of bacterial growth-supporting conditions, such as complex media	474:550	Lst and PlyPH show reduced activity in the presence of bacterial growth-supporting conditions, such as complex media.
33531052	8	0	theme	@	1485:1485	arg1	hydrogel					1489:1496	the TGF-β1@CS/BMP-2@SF hydrogel	1466:1496	the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study	1466:1527	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	3	1	theme	knee	489:492	arg1	defects					510:516	repair knee joint cartilage defects	482:516	repair knee joint cartilage defects	482:516	Therefore, the aim of the present study was to assess the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects.
33531052	5	2	theme	cartilage	1081:1089	arg1	defects					1091:1097	knee joint cartilage defects	1070:1097	knee joint cartilage defects	1070:1097	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	7	3	theme	@	1256:1256	arg1	extracts					1260:1267	TGF-β1@CS/BMP-2@SF extracts	1241:1267	TGF-β1@CS/BMP-2@SF extracts	1241:1267	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	7	4	theme	enhanced	1313:1320	arg1	ability					1335:1341	enhanced chondrogenic ability	1313:1341	enhanced chondrogenic ability	1313:1341	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	4	5	theme	NPs	565:567	arg1	systems					551:557	composite systems	541:557	composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF)	541:717	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	8	6	theme	@	1476:1476	arg1	hydrogel					1489:1496	the TGF-β1@CS/BMP-2@SF hydrogel	1466:1496	the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study	1466:1527	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	5	7	from	evaluations	1037:1047	arg1	model					1061:1065	a rabbit model	1052:1065	a rabbit model of knee joint cartilage defects	1052:1097	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	8	8	theme	BMSCs	1562:1566	arg1	ability					1551:1557	chondrogenic ability	1538:1557	chondrogenic ability of BMSCs	1538:1566	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	4	9	theme	@	632:632	arg1	factor-β1					607:615	transforming growth factor-β1	587:615	transforming growth factor-β1 (TGF-β1; TGF-β1@CS)	587:635	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	4	9	theme	@	632:632	arg1	CS					633:634	TGF-β1; TGF-β1@CS	618:634	TGF-β1; TGF-β1@CS	618:634	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	6	10	theme	SF	1132:1133	arg1	system					1145:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system was successfully characterized and showed favorable biocompatibility.
33531052	4	11	theme	zeta	793:796	arg1	potential					798:806	zeta potential	793:806	zeta potential	793:806	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	7	12	theme	normal	1286:1291	arg1	morphology					1298:1307	normal cell morphology	1286:1307	normal cell morphology	1286:1307	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	6	13	theme	CS/BMP-2	1123:1130	arg1	system					1145:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system was successfully characterized and showed favorable biocompatibility.
33531052	4	14	theme	BMP-2	847:851	arg1	morphology					809:818	morphology	809:818	morphology	809:818	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	4	14	theme	BMP-2	847:851	arg1	distribution					779:790	their size distribution	768:790	their size distribution	768:790	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	4	14	theme	BMP-2	847:851	arg1	potential					798:806	zeta potential	793:806	zeta potential	793:806	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	4	14	theme	BMP-2	847:851	arg1	release					825:831	release	825:831	release	825:831	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	1	15	theme	limited	215:221	arg1	abilities					235:243	limited self-repair abilities	215:243	limited self-repair abilities	215:243	Cartilage defects frequently occur around the knee joint yet cartilage has limited self-repair abilities.
33531052	6	16	theme	@	1122:1122	arg1	system					1145:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system was successfully characterized and showed favorable biocompatibility.
33531052	5	17	theme	cell	980:983	arg1	assay					1000:1004	a cell counting kit-8 assay	978:1004	a cell counting kit-8 assay	978:1004	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	4	18	theme	present	526:532	arg1	study					534:538	the present study	522:538	the present study	522:538	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	6	19	theme	constructed	1104:1114	arg1	system					1145:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system was successfully characterized and showed favorable biocompatibility.
33531052	4	20	theme	morphogenetic	667:679	arg1	BMP-2					692:696	BMP-2	692:696	BMP-2; TGF-β1@CS/BMP-2@SF	692:716	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	4	20	theme	morphogenetic	667:679	arg1	protein-2					681:689	bone morphogenetic protein-2	662:689	bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF)	662:717	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	6	21	theme	favorable	1194:1202	arg1	biocompatibility					1204:1219	favorable biocompatibility	1194:1219	favorable biocompatibility	1194:1219	The constructed TGF-β1@CS/BMP-2@SF composite system was successfully characterized and showed favorable biocompatibility.
33531052	4	22	theme	TGF-β1	836:841	arg1	morphology					809:818	morphology	809:818	morphology	809:818	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	4	22	theme	TGF-β1	836:841	arg1	distribution					779:790	their size distribution	768:790	their size distribution	768:790	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	4	22	theme	TGF-β1	836:841	arg1	potential					798:806	zeta potential	793:806	zeta potential	793:806	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	4	22	theme	TGF-β1	836:841	arg1	release					825:831	release	825:831	release	825:831	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	7	23	theme	@	1247:1247	arg1	extracts					1260:1267	TGF-β1@CS/BMP-2@SF extracts	1241:1267	TGF-β1@CS/BMP-2@SF extracts	1241:1267	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	4	24	dep	BMP-2	692:696	arg1	SF					715:716	TGF-β1@CS/BMP-2@SF	699:716	BMP-2; TGF-β1@CS/BMP-2@SF	692:716	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	3	25	theme	present	347:353	arg1	study					355:359	the present study	343:359	the present study	343:359	Therefore, the aim of the present study was to assess the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects.
33531052	0	26	theme	repair	73:78	arg1	defects					100:106	repair articular cartilage defects	73:106	repair articular cartilage defects	73:106	Silk fibroin hydrogel scaffolds incorporated with chitosan nanoparticles repair articular cartilage defects by regulating TGF-β1 and BMP-2.
33531052	2	27	theme	excellent	270:278	arg1	potential					280:288	excellent potential	270:288	excellent potential for use	270:296	Hydrogel scaffolds have excellent potential for use in tissue engineering.
33531052	7	28	theme	defects	1451:1457	arg1	alleviation					1426:1436	the alleviation	1422:1436	the alleviation of cartilage defects	1422:1457	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	7	28	theme	defects	1451:1457	arg1	promotion					1390:1398	the promotion	1386:1398	the promotion of cell viability	1386:1416	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	0	29	theme	cartilage	90:98	arg1	defects					100:106	repair articular cartilage defects	73:106	repair articular cartilage defects	73:106	Silk fibroin hydrogel scaffolds incorporated with chitosan nanoparticles repair articular cartilage defects by regulating TGF-β1 and BMP-2.
33531052	8	30	theme	novel	1644:1648	arg1	strategy					1662:1669	a novel therapeutic strategy	1642:1669	a novel therapeutic strategy for repairing articular cartilage defects in knee joints	1642:1726	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	8	31	theme	knee	1716:1719	arg1	joints					1721:1726	knee joints	1716:1726	knee joints	1716:1726	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	4	32	theme	@	714:714	arg1	SF					715:716	TGF-β1@CS/BMP-2@SF	699:716	BMP-2; TGF-β1@CS/BMP-2@SF	692:716	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	5	33	theme	kit-8	994:998	arg1	assay					1000:1004	a cell counting kit-8 assay	978:1004	a cell counting kit-8 assay	978:1004	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	5	34	theme	Bone	854:857	arg1	marrow					859:864	Bone marrow	854:864	Bone marrow stromal cells (BMSCs)	854:886	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	8	35	theme	SF	1486:1487	arg1	hydrogel					1489:1496	the TGF-β1@CS/BMP-2@SF hydrogel	1466:1496	the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study	1466:1527	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	3	36	theme	silk	390:393	arg1	scaffolds					417:425	silk fibroin (SF) hydrogel scaffolds	390:425	silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs)	390:477	Therefore, the aim of the present study was to assess the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects.
33531052	3	37	theme	scaffolds	417:425	arg1	ability					379:385	the ability	375:385	the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects	375:516	Therefore, the aim of the present study was to assess the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects.
33531052	0	38	theme	Silk	0:3	arg1	scaffolds					22:30	Silk fibroin hydrogel scaffolds	0:30	Silk fibroin hydrogel scaffolds incorporated with chitosan	0:57	Silk fibroin hydrogel scaffolds incorporated with chitosan nanoparticles repair articular cartilage defects by regulating TGF-β1 and BMP-2.
33531052	5	39	theme	rabbit	1054:1059	arg1	model					1061:1065	a rabbit model	1052:1065	a rabbit model of knee joint cartilage defects	1052:1097	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	8	40	theme	cartilage	1695:1703	arg1	defects					1705:1711	articular cartilage defects	1685:1711	articular cartilage defects in knee joints	1685:1726	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	5	41	theme	stromal	866:872	arg1	cells					874:878	Bone marrow stromal cells	854:878	Bone marrow stromal cells (BMSCs)	854:886	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	5	41	theme	stromal	866:872	arg1	BMSCs					881:885	BMSCs	881:885	BMSCs	881:885	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	5	42	dep	in	1029:1030	arg1	vivo					1032:1035	vivo	1032:1035	vivo	1032:1035	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	4	43	theme	@	705:705	arg1	SF					715:716	TGF-β1@CS/BMP-2@SF	699:716	BMP-2; TGF-β1@CS/BMP-2@SF	692:716	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	0	44	theme	hydrogel	13:20	arg1	scaffolds					22:30	Silk fibroin hydrogel scaffolds	0:30	Silk fibroin hydrogel scaffolds incorporated with chitosan	0:57	Silk fibroin hydrogel scaffolds incorporated with chitosan nanoparticles repair articular cartilage defects by regulating TGF-β1 and BMP-2.
33531052	7	45	theme	cell	1403:1406	arg1	viability					1408:1416	cell viability	1403:1416	cell viability	1403:1416	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	8	46	from	defects	1705:1711	arg1	joints					1721:1726	knee joints	1716:1726	knee joints	1716:1726	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	5	47	theme	SF	926:927	arg1	extracts					929:936	TGF-β1@CS/BMP-2@SF extracts	910:936	TGF-β1@CS/BMP-2@SF extracts	910:936	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	5	48	theme	TGF-β1	910:915	arg1	extracts					929:936	TGF-β1@CS/BMP-2@SF extracts	910:936	TGF-β1@CS/BMP-2@SF extracts	910:936	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	1	49	contain	has	211:213	arg2	abilities					235:243	limited self-repair abilities	215:243	limited self-repair abilities	215:243	Cartilage defects frequently occur around the knee joint yet cartilage has limited self-repair abilities.
33531052	1	49	contain	has	211:213	arg1	cartilage					201:209	cartilage	201:209	cartilage	201:209	Cartilage defects frequently occur around the knee joint yet cartilage has limited self-repair abilities.
33531052	3	50	theme	joint	494:498	arg1	defects					510:516	repair knee joint cartilage defects	482:516	repair knee joint cartilage defects	482:516	Therefore, the aim of the present study was to assess the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects.
33531052	5	51	theme	CS/BMP-2	917:924	arg1	extracts					929:936	TGF-β1@CS/BMP-2@SF extracts	910:936	TGF-β1@CS/BMP-2@SF extracts	910:936	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	4	52	theme	transforming	587:598	arg1	factor-β1					607:615	transforming growth factor-β1	587:615	transforming growth factor-β1 (TGF-β1; TGF-β1@CS)	587:635	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	4	52	theme	transforming	587:598	arg1	CS					633:634	TGF-β1; TGF-β1@CS	618:634	TGF-β1; TGF-β1@CS	618:634	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	3	53	theme	repair	482:487	arg1	defects					510:516	repair knee joint cartilage defects	482:516	repair knee joint cartilage defects	482:516	Therefore, the aim of the present study was to assess the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects.
33531052	5	54	theme	joint	1075:1079	arg1	defects					1091:1097	knee joint cartilage defects	1070:1097	knee joint cartilage defects	1070:1097	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	8	55	theme	CS/BMP-2	1477:1484	arg1	hydrogel					1489:1496	the TGF-β1@CS/BMP-2@SF hydrogel	1466:1496	the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study	1466:1527	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	8	56	theme	chondrogenic	1538:1549	arg1	ability					1551:1557	chondrogenic ability	1538:1557	chondrogenic ability of BMSCs	1538:1566	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	5	57	theme	defects	1091:1097	arg1	model					1061:1065	a rabbit model	1052:1065	a rabbit model of knee joint cartilage defects	1052:1097	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	7	58	theme	chondrogenic	1322:1333	arg1	ability					1335:1341	enhanced chondrogenic ability	1313:1341	enhanced chondrogenic ability	1313:1341	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	4	59	theme	CS	562:563	arg1	NPs					565:567	CS NPs	562:567	CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF)	562:717	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	6	60	theme	composite	1135:1143	arg1	system					1145:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system was successfully characterized and showed favorable biocompatibility.
33531052	2	61	theme	tissue	301:306	arg1	engineering					308:318	tissue engineering	301:318	tissue engineering	301:318	Hydrogel scaffolds have excellent potential for use in tissue engineering.
33531052	1	62	theme	knee	186:189	arg1	joint					191:195	the knee joint	182:195	the knee joint	182:195	Cartilage defects frequently occur around the knee joint yet cartilage has limited self-repair abilities.
33531052	4	63	theme	size	774:777	arg1	distribution					779:790	their size distribution	768:790	their size distribution	768:790	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	6	64	theme	@	1131:1131	arg1	system					1145:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system was successfully characterized and showed favorable biocompatibility.
33531052	7	65	dep	extracts	1260:1267	arg1	the					1225:1227	the	1225:1227	the	1225:1227	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	7	65	dep	extracts	1260:1267	arg1	presence					1229:1236	presence	1229:1236	presence	1229:1236	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	7	66	theme	cell	1293:1296	arg1	morphology					1298:1307	normal cell morphology	1286:1307	normal cell morphology	1286:1307	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	1	67	theme	self-repair	223:233	arg1	abilities					235:243	limited self-repair abilities	215:243	limited self-repair abilities	215:243	Cartilage defects frequently occur around the knee joint yet cartilage has limited self-repair abilities.
33531052	6	68	theme	TGF-β1	1116:1121	arg1	system					1145:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system	1100:1150	The constructed TGF-β1@CS/BMP-2@SF composite system was successfully characterized and showed favorable biocompatibility.
33531052	5	69	theme	counting	985:992	arg1	assay					1000:1004	a cell counting kit-8 assay	978:1004	a cell counting kit-8 assay	978:1004	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	2	70	theme	Hydrogel	246:253	arg1	scaffolds					255:263	Hydrogel scaffolds	246:263	Hydrogel scaffolds	246:263	Hydrogel scaffolds have excellent potential for use in tissue engineering.
33531052	7	71	theme	SF	1257:1258	arg1	extracts					1260:1267	TGF-β1@CS/BMP-2@SF extracts	1241:1267	TGF-β1@CS/BMP-2@SF extracts	1241:1267	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	4	72	theme	bone	662:665	arg1	BMP-2					692:696	BMP-2	692:696	BMP-2; TGF-β1@CS/BMP-2@SF	692:716	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	4	72	theme	bone	662:665	arg1	protein-2					681:689	bone morphogenetic protein-2	662:689	bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF)	662:717	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	1	73	theme	Cartilage	140:148	arg1	defects					150:156	Cartilage defects	140:156	Cartilage defects	140:156	Cartilage defects frequently occur around the knee joint yet cartilage has limited self-repair abilities.
33531052	7	74	theme	CS/BMP-2	1248:1255	arg1	extracts					1260:1267	TGF-β1@CS/BMP-2@SF extracts	1241:1267	TGF-β1@CS/BMP-2@SF extracts	1241:1267	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	0	75	theme	articular	80:88	arg1	defects					100:106	repair articular cartilage defects	73:106	repair articular cartilage defects	73:106	Silk fibroin hydrogel scaffolds incorporated with chitosan nanoparticles repair articular cartilage defects by regulating TGF-β1 and BMP-2.
33531052	7	76	theme	cartilage	1441:1449	arg1	defects					1451:1457	cartilage defects	1441:1457	cartilage defects	1441:1457	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	3	77	theme	study	355:359	arg1	aim					336:338	the aim	332:338	the aim of the present study	332:359	Therefore, the aim of the present study was to assess the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects.
33531052	7	78	theme	TGF-β1	1241:1246	arg1	extracts					1260:1267	TGF-β1@CS/BMP-2@SF extracts	1241:1267	TGF-β1@CS/BMP-2@SF extracts	1241:1267	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	5	79	theme	in	1029:1030	arg1	evaluations					1037:1047	in vivo evaluations	1029:1047	in vivo evaluations in a rabbit model of knee joint cartilage defects	1029:1097	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	4	80	theme	CS/BMP-2	706:713	arg1	SF					715:716	TGF-β1@CS/BMP-2@SF	699:716	BMP-2; TGF-β1@CS/BMP-2@SF	692:716	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	8	81	theme	therapeutic	1650:1660	arg1	strategy					1662:1669	a novel therapeutic strategy	1642:1669	a novel therapeutic strategy for repairing articular cartilage defects in knee joints	1642:1726	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	3	82	theme	chitosan	445:452	arg1	NPs					474:476	NPs	474:476	NPs	474:476	Therefore, the aim of the present study was to assess the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects.
33531052	3	82	theme	chitosan	445:452	arg1	nanoparticles					459:471	chitosan (CS) nanoparticles	445:471	chitosan (CS) nanoparticles (NPs)	445:477	Therefore, the aim of the present study was to assess the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects.
33531052	0	83	theme	fibroin	5:11	arg1	scaffolds					22:30	Silk fibroin hydrogel scaffolds	0:30	Silk fibroin hydrogel scaffolds incorporated with chitosan	0:57	Silk fibroin hydrogel scaffolds incorporated with chitosan nanoparticles repair articular cartilage defects by regulating TGF-β1 and BMP-2.
33531052	5	84	theme	marrow	859:864	arg1	cells					874:878	Bone marrow stromal cells	854:878	Bone marrow stromal cells (BMSCs)	854:886	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	5	84	theme	marrow	859:864	arg1	BMSCs					881:885	BMSCs	881:885	BMSCs	881:885	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	3	85	theme	fibroin	395:401	arg1	scaffolds					417:425	silk fibroin (SF) hydrogel scaffolds	390:425	silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs)	390:477	Therefore, the aim of the present study was to assess the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects.
33531052	8	86	theme	articular	1685:1693	arg1	defects					1705:1711	articular cartilage defects	1685:1711	articular cartilage defects in knee joints	1685:1726	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	4	87	theme	composite	541:549	arg1	systems					551:557	composite systems	541:557	composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF)	541:717	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	4	88	theme	TGF-β1	699:704	arg1	SF					715:716	TGF-β1@CS/BMP-2@SF	699:716	BMP-2; TGF-β1@CS/BMP-2@SF	692:716	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	5	89	theme	knee	1070:1073	arg1	defects					1091:1097	knee joint cartilage defects	1070:1097	knee joint cartilage defects	1070:1097	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	7	90	theme	viability	1408:1416	arg1	alleviation					1426:1436	the alleviation	1422:1436	the alleviation of cartilage defects	1422:1457	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	7	90	theme	viability	1408:1416	arg1	promotion					1390:1398	the promotion	1386:1398	the promotion of cell viability	1386:1416	In the presence of TGF-β1@CS/BMP-2@SF extracts, BMSCs exhibited normal cell morphology and enhanced chondrogenic ability both in vitro and in vivo, as evidenced by the promotion of cell viability and the alleviation of cartilage defects.
33531052	5	91	theme	@	925:925	arg1	extracts					929:936	TGF-β1@CS/BMP-2@SF extracts	910:936	TGF-β1@CS/BMP-2@SF extracts	910:936	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	3	92	theme	hydrogel	408:415	arg1	scaffolds					417:425	silk fibroin (SF) hydrogel scaffolds	390:425	silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs)	390:477	Therefore, the aim of the present study was to assess the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects.
33531052	4	93	theme	growth	600:605	arg1	factor-β1					607:615	transforming growth factor-β1	587:615	transforming growth factor-β1 (TGF-β1; TGF-β1@CS)	587:635	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	4	93	theme	growth	600:605	arg1	CS					633:634	TGF-β1; TGF-β1@CS	618:634	TGF-β1; TGF-β1@CS	618:634	In the present study, composite systems of CS NPs incorporated with transforming growth factor-β1 (TGF-β1; TGF-β1@CS) and SF incorporated with bone morphogenetic protein-2 (BMP-2; TGF-β1@CS/BMP-2@SF) were developed and characterized with respect to their size distribution, zeta potential, morphology, and release of TGF-β1 and BMP-2.
33531052	3	94	theme	SF	404:405	arg1	scaffolds					417:425	silk fibroin (SF) hydrogel scaffolds	390:425	silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs)	390:477	Therefore, the aim of the present study was to assess the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects.
33531052	8	95	theme	present	1515:1521	arg1	study					1523:1527	the present study	1511:1527	the present study	1511:1527	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	5	96	theme	@	916:916	arg1	extracts					929:936	TGF-β1@CS/BMP-2@SF extracts	910:936	TGF-β1@CS/BMP-2@SF extracts	910:936	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	5	97	dep	using	972:976	arg1	followed					1017:1024	followed	1017:1024	was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects	1013:1097	Bone marrow stromal cells (BMSCs) were co-cultured with TGF-β1@CS/BMP-2@SF extracts to assess chondrogenesis in vitro using a cell counting kit-8 assay, which was followed by in vivo evaluations in a rabbit model of knee joint cartilage defects.
33531052	8	98	theme	TGF-β1	1470:1475	arg1	hydrogel					1489:1496	the TGF-β1@CS/BMP-2@SF hydrogel	1466:1496	the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study	1466:1527	Thus, the TGF-β1@CS/BMP-2@SF hydrogel developed in the present study promoted chondrogenic ability of BMSCs both in vivo and in vitro by releasing TGF-β1 and BMP-2, thereby offering a novel therapeutic strategy for repairing articular cartilage defects in knee joints.
33531052	3	99	theme	cartilage	500:508	arg1	defects					510:516	repair knee joint cartilage defects	482:516	repair knee joint cartilage defects	482:516	Therefore, the aim of the present study was to assess the ability of silk fibroin (SF) hydrogel scaffolds incorporated with chitosan (CS) nanoparticles (NPs) to repair knee joint cartilage defects.
33531052	2	100	contain	have	265:268	arg1	scaffolds					255:263	Hydrogel scaffolds	246:263	Hydrogel scaffolds	246:263	Hydrogel scaffolds have excellent potential for use in tissue engineering.
33531052	2	100	contain	have	265:268	arg2	potential					280:288	excellent potential	270:288	excellent potential for use	270:296	Hydrogel scaffolds have excellent potential for use in tissue engineering.
32574734	8	0	theme	new	1451:1453	arg1	tissue					1455:1460	new tissue	1451:1460	new tissue with most similarity to the normal skin	1451:1500	The in-vivo wound healing results in rat elucidated more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed.
32574734	8	1	theme	wound	1388:1392	arg1	healing					1394:1400	more wound healing	1383:1400	more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed	1383:1511	The in-vivo wound healing results in rat elucidated more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed.
32574734	4	2	theme	possible	692:699	arg1	interactions					701:712	possible interactions	692:712	possible interactions	692:712	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	1	3	theme	ideal	262:266	arg1	scaffold					268:275	an ideal scaffold	259:275	an ideal scaffold for tissue regeneration	259:299	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	0	4	theme	wound	103:107	arg1	dressing					109:116	a wound dressing	101:116	a wound dressing	101:116	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.
32574734	2	5	with	biopolymers	409:419	arg1	similarity					437:446	structural similarity	426:446	structural similarity to ECM and wound healing properties	426:482	In order to resemble the fibrous/gel structure of skin ECM, a multicomponent scaffold was fabricated using biopolymers with structural similarity to ECM and wound healing properties i.e., chitosan (CS), gelatin (Gel) and hyaluronic acid (HA).
32574734	5	6	theme	CS-HA	917:921	arg1	fibers					923:928	CS-HA fibers	917:928	CS-HA fibers	917:928	The noncomplex component of CS-HA fibers formed a gel state when the scaffold was exposed to the aqueous media, while the CS-Gel fibers reserved their fibrous structure, resulting in formation of fibrous/gel structure.
32574734	1	7	theme	scaffold	268:275	arg1	similarity					178:187	Structural and compositional similarity	149:187	similarity	178:187	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	1	7	theme	scaffold	268:275	arg1	characteristic					241:254	a main characteristic	234:254	a main characteristic of an ideal scaffold for tissue regeneration	234:299	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	0	8	theme	In-vitro	119:126	arg1	studies					140:146	In-vitro and in-vivo studies	119:146	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.	0:147	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.
32574734	2	9	dep	chitosan	490:497	arg1	i.e.					484:487	i.e.	484:487	i.e.	484:487	In order to resemble the fibrous/gel structure of skin ECM, a multicomponent scaffold was fabricated using biopolymers with structural similarity to ECM and wound healing properties i.e., chitosan (CS), gelatin (Gel) and hyaluronic acid (HA).
32574734	7	10	theme	HA	1327:1328	arg1	incorporation					1310:1322	incorporation	1310:1322	incorporation of HA	1310:1328	Additionally, the initial cell adhesion improved by incorporation of HA.
32574734	6	11	theme	higher	1155:1160	arg1	proliferation					1167:1179	significantly higher cell proliferation	1141:1179	significantly higher cell proliferation (109%)	1141:1186	The CS-Gel/CS-HA scaffold showed significantly higher cell proliferation (109%) in the first 24 h comparing with CS (90%) and CS-Gel (96%) scaffolds.
32574734	6	11	theme	higher	1155:1160	arg1	%					1185:1185	109%	1182:1185	109%	1182:1185	The CS-Gel/CS-HA scaffold showed significantly higher cell proliferation (109%) in the first 24 h comparing with CS (90%) and CS-Gel (96%) scaffolds.
32574734	4	12	theme	polyelectrolyte	732:746	arg1	complex					748:754	polyelectrolyte complex	732:754	polyelectrolyte complex	732:754	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	5	13	theme	fibrous/gel	1085:1095	arg1	structure					1097:1105	fibrous/gel structure	1085:1105	fibrous/gel structure	1085:1105	The noncomplex component of CS-HA fibers formed a gel state when the scaffold was exposed to the aqueous media, while the CS-Gel fibers reserved their fibrous structure, resulting in formation of fibrous/gel structure.
32574734	1	14	theme	tissue	281:286	arg1	regeneration					288:299	tissue regeneration	281:299	tissue regeneration	281:299	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	0	15	theme	in-vivo	132:138	arg1	studies					140:146	In-vitro and in-vivo studies	119:146	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.	0:147	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.
32574734	5	16	theme	structure	1097:1105	arg1	formation					1072:1080	formation	1072:1080	formation of fibrous/gel structure	1072:1105	The noncomplex component of CS-HA fibers formed a gel state when the scaffold was exposed to the aqueous media, while the CS-Gel fibers reserved their fibrous structure, resulting in formation of fibrous/gel structure.
32574734	4	17	theme	thermogravimetric	855:871	arg1	analysis					873:880	thermogravimetric analysis	855:880	thermogravimetric analysis (TGA)	855:886	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	4	17	theme	thermogravimetric	855:871	arg1	TGA					883:885	TGA	883:885	TGA	883:885	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	8	18	dep	results	1357:1363	arg1	elucidated					1372:1381	elucidated	1372:1381	elucidated more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed	1372:1511	The in-vivo wound healing results in rat elucidated more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed.
32574734	4	19	theme	total	782:786	arg1	Fourier					800:806	attenuated total reflectance Fourier	771:806	attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA)	771:886	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	8	20	with	tissue	1455:1460	arg1	similarity					1472:1481	most similarity	1467:1481	most similarity to the normal skin	1467:1500	The in-vivo wound healing results in rat elucidated more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed.
32574734	1	21	theme	natural	196:202	arg1	matrix					218:223	the natural extracellular matrix	192:223	the natural extracellular matrix (ECM)	192:229	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	1	21	theme	natural	196:202	arg1	ECM					226:228	ECM	226:228	ECM	226:228	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	8	22	theme	normal	1490:1495	arg1	skin					1497:1500	the normal skin	1486:1500	the normal skin	1486:1500	The in-vivo wound healing results in rat elucidated more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed.
32574734	2	23	dep	ECM	451:453	arg1	properties					473:482	properties	473:482	properties	473:482	In order to resemble the fibrous/gel structure of skin ECM, a multicomponent scaffold was fabricated using biopolymers with structural similarity to ECM and wound healing properties i.e., chitosan (CS), gelatin (Gel) and hyaluronic acid (HA).
32574734	0	24	theme	Dual	0:3	arg1	structure					43:51	Dual spinneret electrospun nanofibrous/gel structure	0:51	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.	0:147	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.
32574734	8	25	theme	CS-Gel/CS-HA	1420:1431	arg1	scaffold					1433:1440	the CS-Gel/CS-HA scaffold	1416:1440	the CS-Gel/CS-HA scaffold	1416:1440	The in-vivo wound healing results in rat elucidated more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed.
32574734	1	26	theme	extracellular	204:216	arg1	matrix					218:223	the natural extracellular matrix	192:223	the natural extracellular matrix (ECM)	192:229	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	1	26	theme	extracellular	204:216	arg1	ECM					226:228	ECM	226:228	ECM	226:228	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	0	27	theme	spinneret	5:13	arg1	structure					43:51	Dual spinneret electrospun nanofibrous/gel structure	0:51	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.	0:147	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.
32574734	2	28	theme	fibrous/gel	327:337	arg1	structure					339:347	the fibrous/gel structure	323:347	the fibrous/gel structure of skin ECM	323:359	In order to resemble the fibrous/gel structure of skin ECM, a multicomponent scaffold was fabricated using biopolymers with structural similarity to ECM and wound healing properties i.e., chitosan (CS), gelatin (Gel) and hyaluronic acid (HA).
32574734	4	29	dep	Fourier	800:806	arg1	transform					808:816	transform	808:816	transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA)	808:886	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	2	30	theme	wound	459:463	arg1	healing					465:471	wound healing	459:471	wound healing	459:471	In order to resemble the fibrous/gel structure of skin ECM, a multicomponent scaffold was fabricated using biopolymers with structural similarity to ECM and wound healing properties i.e., chitosan (CS), gelatin (Gel) and hyaluronic acid (HA).
32574734	7	31	theme	initial	1276:1282	arg1	adhesion					1289:1296	the initial cell adhesion	1272:1296	the initial cell adhesion	1272:1296	Additionally, the initial cell adhesion improved by incorporation of HA.
32574734	0	32	theme	nanofibrous/gel	27:41	arg1	structure					43:51	Dual spinneret electrospun nanofibrous/gel structure	0:51	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.	0:147	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.
32574734	6	33	theme	first	1195:1199	arg1	24 h					1201:1204	the first 24 h	1191:1204	the first 24 h comparing with CS (90%) and CS-Gel (96%) scaffolds	1191:1255	The CS-Gel/CS-HA scaffold showed significantly higher cell proliferation (109%) in the first 24 h comparing with CS (90%) and CS-Gel (96%) scaffolds.
32574734	6	34	theme	cell	1162:1165	arg1	proliferation					1167:1179	significantly higher cell proliferation	1141:1179	significantly higher cell proliferation (109%)	1141:1186	The CS-Gel/CS-HA scaffold showed significantly higher cell proliferation (109%) in the first 24 h comparing with CS (90%) and CS-Gel (96%) scaffolds.
32574734	6	34	theme	cell	1162:1165	arg1	%					1185:1185	109%	1182:1185	109%	1182:1185	The CS-Gel/CS-HA scaffold showed significantly higher cell proliferation (109%) in the first 24 h comparing with CS (90%) and CS-Gel (96%) scaffolds.
32574734	4	35	theme	ATR-FTIR	828:835	arg1	spectroscopy					838:849	infrared (ATR-FTIR) spectroscopy	818:849	infrared (ATR-FTIR) spectroscopy	818:849	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	0	36	theme	electrospun	15:25	arg1	structure					43:51	Dual spinneret electrospun nanofibrous/gel structure	0:51	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.	0:147	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.
32574734	4	37	theme	complex	748:754	arg1	polymers					682:689	polymers	682:689	polymers	682:689	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	4	37	theme	complex	748:754	arg1	interactions					701:712	possible interactions	692:712	possible interactions	692:712	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	4	37	theme	complex	748:754	arg1	formation					719:727	formation	719:727	formation of polyelectrolyte complex	719:754	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	4	38	theme	polymers	682:689	arg1	presence					670:677	The presence	666:677	The presence of polymers, possible interactions, and formation of polyelectrolyte complex	666:754	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	4	39	theme	interactions	701:712	arg1	presence					670:677	The presence	666:677	The presence of polymers, possible interactions, and formation of polyelectrolyte complex	666:754	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	2	40	theme	hyaluronic	523:532	arg1	acid					534:537	hyaluronic acid	523:537	hyaluronic acid (HA)	523:542	In order to resemble the fibrous/gel structure of skin ECM, a multicomponent scaffold was fabricated using biopolymers with structural similarity to ECM and wound healing properties i.e., chitosan (CS), gelatin (Gel) and hyaluronic acid (HA).
32574734	2	40	theme	hyaluronic	523:532	arg1	HA					540:541	HA	540:541	HA	540:541	In order to resemble the fibrous/gel structure of skin ECM, a multicomponent scaffold was fabricated using biopolymers with structural similarity to ECM and wound healing properties i.e., chitosan (CS), gelatin (Gel) and hyaluronic acid (HA).
32574734	3	41	theme	dual-electrospinning	634:653	arg1	technique					655:663	dual-electrospinning technique	634:663	dual-electrospinning technique	634:663	The CS-Gel and CS-HA nanofibers were simultaneously electrospun on the collector through dual-electrospinning technique.
32574734	3	42	theme	CS-HA	560:564	arg1	nanofibers					566:575	The CS-Gel and CS-HA nanofibers	545:575	The CS-Gel and CS-HA nanofibers	545:575	The CS-Gel and CS-HA nanofibers were simultaneously electrospun on the collector through dual-electrospinning technique.
32574734	2	43	theme	structural	426:435	arg1	similarity					437:446	structural similarity	426:446	structural similarity to ECM and wound healing properties	426:482	In order to resemble the fibrous/gel structure of skin ECM, a multicomponent scaffold was fabricated using biopolymers with structural similarity to ECM and wound healing properties i.e., chitosan (CS), gelatin (Gel) and hyaluronic acid (HA).
32574734	7	44	theme	cell	1284:1287	arg1	adhesion					1289:1296	the initial cell adhesion	1272:1296	the initial cell adhesion	1272:1296	Additionally, the initial cell adhesion improved by incorporation of HA.
32574734	5	45	theme	CS-Gel	1011:1016	arg1	fibers					1018:1023	the CS-Gel fibers	1007:1023	the CS-Gel fibers	1007:1023	The noncomplex component of CS-HA fibers formed a gel state when the scaffold was exposed to the aqueous media, while the CS-Gel fibers reserved their fibrous structure, resulting in formation of fibrous/gel structure.
32574734	0	46	theme	acid	93:96	arg1	structure					43:51	Dual spinneret electrospun nanofibrous/gel structure	0:51	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.	0:147	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.
32574734	5	47	theme	noncomplex	893:902	arg1	component					904:912	The noncomplex component	889:912	The noncomplex component of CS-HA fibers	889:928	The noncomplex component of CS-HA fibers formed a gel state when the scaffold was exposed to the aqueous media, while the CS-Gel fibers reserved their fibrous structure, resulting in formation of fibrous/gel structure.
32574734	3	48	theme	CS-Gel	549:554	arg1	nanofibers					566:575	The CS-Gel and CS-HA nanofibers	545:575	The CS-Gel and CS-HA nanofibers	545:575	The CS-Gel and CS-HA nanofibers were simultaneously electrospun on the collector through dual-electrospinning technique.
32574734	2	49	theme	ECM	357:359	arg1	structure					339:347	the fibrous/gel structure	323:347	the fibrous/gel structure of skin ECM	323:359	In order to resemble the fibrous/gel structure of skin ECM, a multicomponent scaffold was fabricated using biopolymers with structural similarity to ECM and wound healing properties i.e., chitosan (CS), gelatin (Gel) and hyaluronic acid (HA).
32574734	0	50	theme	chitosan-gelatin/chitosan-hyaluronic	56:91	arg1	acid					93:96	chitosan-gelatin/chitosan-hyaluronic acid	56:96	chitosan-gelatin/chitosan-hyaluronic acid	56:96	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.
32574734	6	51	dep	CS	1221:1222	arg1	scaffolds					1247:1255	scaffolds	1247:1255	scaffolds	1247:1255	The CS-Gel/CS-HA scaffold showed significantly higher cell proliferation (109%) in the first 24 h comparing with CS (90%) and CS-Gel (96%) scaffolds.
32574734	8	52	theme	scaffold	1433:1440	arg1	capability					1402:1411	more wound healing capability	1383:1411	more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed	1383:1511	The in-vivo wound healing results in rat elucidated more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed.
32574734	0	53	dep	structure	43:51	arg1	studies					140:146	In-vitro and in-vivo studies	119:146	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.	0:147	Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: In-vitro and in-vivo studies.
32574734	2	54	theme	skin	352:355	arg1	ECM					357:359	skin ECM	352:359	skin ECM	352:359	In order to resemble the fibrous/gel structure of skin ECM, a multicomponent scaffold was fabricated using biopolymers with structural similarity to ECM and wound healing properties i.e., chitosan (CS), gelatin (Gel) and hyaluronic acid (HA).
32574734	8	55	theme	healing	1394:1400	arg1	capability					1402:1411	more wound healing capability	1383:1411	more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed	1383:1511	The in-vivo wound healing results in rat elucidated more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed.
32574734	5	56	theme	fibrous	1040:1046	arg1	structure					1048:1056	their fibrous structure	1034:1056	their fibrous structure	1034:1056	The noncomplex component of CS-HA fibers formed a gel state when the scaffold was exposed to the aqueous media, while the CS-Gel fibers reserved their fibrous structure, resulting in formation of fibrous/gel structure.
32574734	5	57	theme	aqueous	986:992	arg1	media					994:998	the aqueous media	982:998	the aqueous media	982:998	The noncomplex component of CS-HA fibers formed a gel state when the scaffold was exposed to the aqueous media, while the CS-Gel fibers reserved their fibrous structure, resulting in formation of fibrous/gel structure.
32574734	8	58	theme	wound	1343:1347	arg1	healing					1349:1355	The in-vivo wound healing	1331:1355	The in-vivo wound healing	1331:1355	The in-vivo wound healing results in rat elucidated more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed.
32574734	1	59	theme	Structural	149:158	arg1	similarity					178:187	Structural and compositional similarity	149:187	similarity	178:187	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	1	59	theme	Structural	149:158	arg1	characteristic					241:254	a main characteristic	234:254	a main characteristic of an ideal scaffold for tissue regeneration	234:299	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	6	60	theme	CS-Gel/CS-HA	1112:1123	arg1	scaffold					1125:1132	The CS-Gel/CS-HA scaffold	1108:1132	The CS-Gel/CS-HA scaffold	1108:1132	The CS-Gel/CS-HA scaffold showed significantly higher cell proliferation (109%) in the first 24 h comparing with CS (90%) and CS-Gel (96%) scaffolds.
32574734	1	61	theme	main	236:239	arg1	similarity					178:187	Structural and compositional similarity	149:187	similarity	178:187	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	1	61	theme	main	236:239	arg1	characteristic					241:254	a main characteristic	234:254	a main characteristic of an ideal scaffold for tissue regeneration	234:299	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	4	62	theme	attenuated	771:780	arg1	Fourier					800:806	attenuated total reflectance Fourier	771:806	attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA)	771:886	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	5	63	theme	fibers	923:928	arg1	component					904:912	The noncomplex component	889:912	The noncomplex component of CS-HA fibers	889:928	The noncomplex component of CS-HA fibers formed a gel state when the scaffold was exposed to the aqueous media, while the CS-Gel fibers reserved their fibrous structure, resulting in formation of fibrous/gel structure.
32574734	4	64	theme	reflectance	788:798	arg1	Fourier					800:806	attenuated total reflectance Fourier	771:806	attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA)	771:886	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	5	65	theme	gel	939:941	arg1	state					943:947	a gel state	937:947	a gel state when the scaffold was exposed to the aqueous media	937:998	The noncomplex component of CS-HA fibers formed a gel state when the scaffold was exposed to the aqueous media, while the CS-Gel fibers reserved their fibrous structure, resulting in formation of fibrous/gel structure.
32574734	4	66	theme	formation	719:727	arg1	presence					670:677	The presence	666:677	The presence of polymers, possible interactions, and formation of polyelectrolyte complex	666:754	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	8	67	theme	most	1467:1470	arg1	similarity					1472:1481	most similarity	1467:1481	most similarity to the normal skin	1467:1500	The in-vivo wound healing results in rat elucidated more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed.
32574734	8	68	theme	in-vivo	1335:1341	arg1	healing					1349:1355	The in-vivo wound healing	1331:1355	The in-vivo wound healing	1331:1355	The in-vivo wound healing results in rat elucidated more wound healing capability of the CS-Gel/CS-HA scaffold in which new tissue with most similarity to the normal skin was formed.
32574734	4	69	theme	infrared	818:825	arg1	spectroscopy					838:849	infrared (ATR-FTIR) spectroscopy	818:849	infrared (ATR-FTIR) spectroscopy	818:849	The presence of polymers, possible interactions, and formation of polyelectrolyte complex were proven by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and thermogravimetric analysis (TGA).
32574734	1	70	theme	compositional	164:176	arg1	similarity					178:187	Structural and compositional similarity	149:187	similarity	178:187	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	1	70	theme	compositional	164:176	arg1	characteristic					241:254	a main characteristic	234:254	a main characteristic of an ideal scaffold for tissue regeneration	234:299	Structural and compositional similarity to the natural extracellular matrix (ECM) is a main characteristic of an ideal scaffold for tissue regeneration.
32574734	2	71	theme	multicomponent	364:377	arg1	scaffold					379:386	a multicomponent scaffold	362:386	a multicomponent scaffold	362:386	In order to resemble the fibrous/gel structure of skin ECM, a multicomponent scaffold was fabricated using biopolymers with structural similarity to ECM and wound healing properties i.e., chitosan (CS), gelatin (Gel) and hyaluronic acid (HA).
33727184	8	0	theme	contact	1348:1354	arg1	angle					1356:1360	water contact angle	1342:1360	water contact angle	1342:1360	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	2	1	theme	system	355:360	arg1	influence					326:334	the influence	322:334	the influence of a novel solvent system	322:360	In this work, with emphasizing the influence of a novel solvent system, an electrospun wound dressing was designed in four steps.
33727184	8	2	theme	angle	1356:1360	arg1	analysis					1418:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	0	3	theme	electrospun	85:95	arg1	design					13:18	Step-by-step design	0:18	Step-by-step design of poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun	0:95	Step-by-step design of poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun nanofibers for wound dressing applications.
33727184	2	4	theme	solvent	347:353	arg1	system					355:360	a novel solvent system	339:360	a novel solvent system	339:360	In this work, with emphasizing the influence of a novel solvent system, an electrospun wound dressing was designed in four steps.
33727184	0	5	theme	wound	112:116	arg1	applications					127:138	wound dressing applications	112:138	wound dressing applications	112:138	Step-by-step design of poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun nanofibers for wound dressing applications.
33727184	3	6	theme	different	661:669	arg1	distances					671:679	different distances	661:679	different distances	661:679	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	1	7	from	type	182:185	arg1	systems					218:224	electrospinning systems	202:224	electrospinning systems	202:224	Composition of polymers and choosing the type of solvents in electrospinning systems is of great importance to achieve a mat with optimal properties.
33727184	3	8	theme	polycaprolactone	533:548	arg1	polycaprolactone					533:548	polycaprolactone	533:548	polycaprolactone (PCL)	533:554	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	3	8	theme	polycaprolactone	533:548	arg1	amount					523:528	a constant amount	512:528	a constant amount of polycaprolactone (PCL)	512:554	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	3	8	theme	polycaprolactone	533:548	arg1	PCL					551:553	PCL	551:553	PCL	551:553	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	8	9	theme	water	1342:1346	arg1	angle					1356:1360	water contact angle	1342:1360	water contact angle	1342:1360	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	1	10	theme	optimal	271:277	arg1	properties					279:288	optimal properties	271:288	optimal properties	271:288	Composition of polymers and choosing the type of solvents in electrospinning systems is of great importance to achieve a mat with optimal properties.
33727184	8	11	theme	optimized	1263:1271	arg1	specimens					1294:1302	the optimized PCL/CN and PCL/CN/MO specimens	1259:1302	the optimized PCL/CN and PCL/CN/MO specimens	1259:1302	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	1	12	dep	polymers	156:163	arg1	choosing					169:176	choosing	169:176	choosing the type of solvents in electrospinning systems	169:224	Composition of polymers and choosing the type of solvents in electrospinning systems is of great importance to achieve a mat with optimal properties.
33727184	3	13	theme	interactions	469:480	arg1	effect					443:448	the effect	439:448	the effect of polymer-solvent interactions	439:480	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	4	14	theme	good	826:829	arg1	uniformity					839:848	good surface uniformity	826:848	good surface uniformity	826:848	The composition of 80FA/20DCM and distance of 15 cm were selected as optimal conditions by lowest average diameter of fibers and simultaneously good surface uniformity.
33727184	7	15	theme	caring	1239:1244	arg1	wound					1233:1237	wound caring	1233:1244	wound caring	1233:1244	The extract contained fibers had a mean diameter of 275 ± 41 nm which is in the required condition for wound caring.
33727184	4	16	theme	optimal	751:757	arg1	composition					686:696	The composition	682:696	The composition of 80FA/20DCM and distance of 15 cm	682:732	The composition of 80FA/20DCM and distance of 15 cm were selected as optimal conditions by lowest average diameter of fibers and simultaneously good surface uniformity.
33727184	4	16	theme	optimal	751:757	arg1	conditions					759:768	optimal conditions	751:768	optimal conditions	751:768	The composition of 80FA/20DCM and distance of 15 cm were selected as optimal conditions by lowest average diameter of fibers and simultaneously good surface uniformity.
33727184	6	17	theme	chitosan	1030:1037	arg1	concentrations					1012:1025	different concentrations	1002:1025	different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract	1002:1100	Finally, in the third and fourth steps, different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract were added to the solution.
33727184	0	18	theme	dressing	118:125	arg1	applications					127:138	wound dressing applications	112:138	wound dressing applications	112:138	Step-by-step design of poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun nanofibers for wound dressing applications.
33727184	6	19	theme	Melilotus	1067:1075	arg1	extract					1094:1100	Melilotus officinalis (MO) extract	1067:1100	Melilotus officinalis (MO) extract	1067:1100	Finally, in the third and fourth steps, different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract were added to the solution.
33727184	5	20	theme	fibers	954:959	arg1	diameter					942:949	the lowest diameter	931:949	the lowest diameter of fibers	931:959	In the second step, the concentration of PCL was considered variable to achieve the lowest diameter of fibers.
33727184	1	21	theme	solvents	190:197	arg1	type					182:185	the type	178:185	the type of solvents in electrospinning systems	178:224	Composition of polymers and choosing the type of solvents in electrospinning systems is of great importance to achieve a mat with optimal properties.
33727184	8	22	theme	Tensile	1333:1339	arg1	analysis					1418:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	4	23	theme	distance	716:723	arg1	composition					686:696	The composition	682:696	The composition of 80FA/20DCM and distance of 15 cm	682:732	The composition of 80FA/20DCM and distance of 15 cm were selected as optimal conditions by lowest average diameter of fibers and simultaneously good surface uniformity.
33727184	4	23	theme	distance	716:723	arg1	conditions					759:768	optimal conditions	751:768	optimal conditions	751:768	The composition of 80FA/20DCM and distance of 15 cm were selected as optimal conditions by lowest average diameter of fibers and simultaneously good surface uniformity.
33727184	2	24	theme	wound	378:382	arg1	dressing					384:391	an electrospun wound dressing	363:391	an electrospun wound dressing	363:391	In this work, with emphasizing the influence of a novel solvent system, an electrospun wound dressing was designed in four steps.
33727184	0	25	theme	Step-by-step	0:11	arg1	design					13:18	Step-by-step design	0:18	Step-by-step design of poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun	0:95	Step-by-step design of poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun nanofibers for wound dressing applications.
33727184	4	26	theme	surface	831:837	arg1	uniformity					839:848	good surface uniformity	826:848	good surface uniformity	826:848	The composition of 80FA/20DCM and distance of 15 cm were selected as optimal conditions by lowest average diameter of fibers and simultaneously good surface uniformity.
33727184	6	27	theme	extract	1094:1100	arg1	chitosan					1030:1037	chitosan	1030:1037	chitosan (CN)	1030:1042	Finally, in the third and fourth steps, different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract were added to the solution.
33727184	6	27	theme	extract	1094:1100	arg1	dosage					1057:1062	constant dosage	1048:1062	constant dosage of Melilotus officinalis (MO) extract	1048:1100	Finally, in the third and fourth steps, different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract were added to the solution.
33727184	6	27	theme	extract	1094:1100	arg1	CN					1040:1041	CN	1040:1041	CN	1040:1041	Finally, in the third and fourth steps, different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract were added to the solution.
33727184	8	28	theme	PCL/CN/MO	1284:1292	arg1	specimens					1294:1302	the optimized PCL/CN and PCL/CN/MO specimens	1259:1302	the optimized PCL/CN and PCL/CN/MO specimens	1259:1302	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	2	29	theme	electrospun	366:376	arg1	dressing					384:391	an electrospun wound dressing	363:391	an electrospun wound dressing	363:391	In this work, with emphasizing the influence of a novel solvent system, an electrospun wound dressing was designed in four steps.
33727184	4	30	theme	average	780:786	arg1	diameter					788:795	lowest average diameter	773:795	lowest average diameter of fibers	773:805	The composition of 80FA/20DCM and distance of 15 cm were selected as optimal conditions by lowest average diameter of fibers and simultaneously good surface uniformity.
33727184	8	31	theme	antibacterial	1363:1375	arg1	assays					1377:1382	antibacterial assays	1363:1382	antibacterial assays	1363:1382	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	4	32	theme	fibers	800:805	arg1	diameter					788:795	lowest average diameter	773:795	lowest average diameter of fibers	773:805	The composition of 80FA/20DCM and distance of 15 cm were selected as optimal conditions by lowest average diameter of fibers and simultaneously good surface uniformity.
33727184	4	33	theme	15 cm	728:732	arg1	distance					716:723	distance	716:723	distance	716:723	The composition of 80FA/20DCM and distance of 15 cm were selected as optimal conditions by lowest average diameter of fibers and simultaneously good surface uniformity.
33727184	4	33	theme	15 cm	728:732	arg1	80FA/20DCM					701:710	80FA/20DCM	701:710	80FA/20DCM	701:710	The composition of 80FA/20DCM and distance of 15 cm were selected as optimal conditions by lowest average diameter of fibers and simultaneously good surface uniformity.
33727184	7	34	contain	contained	1142:1150	arg1	extract					1134:1140	The extract	1130:1140	The extract	1130:1140	The extract contained fibers had a mean diameter of 275 ± 41 nm which is in the required condition for wound caring.
33727184	7	34	contain	contained	1142:1150	arg2	fibers					1152:1157	fibers	1152:1157	fibers had a mean diameter of 275 ± 41 nm which is in the required condition for wound caring	1152:1244	The extract contained fibers had a mean diameter of 275 ± 41 nm which is in the required condition for wound caring.
33727184	8	35	theme	viability	1390:1398	arg1	analysis					1418:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	6	36	theme	MO	1090:1091	arg1	extract					1094:1100	Melilotus officinalis (MO) extract	1067:1100	Melilotus officinalis (MO) extract	1067:1100	Finally, in the third and fourth steps, different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract were added to the solution.
33727184	6	37	theme	different	1002:1010	arg1	concentrations					1012:1025	different concentrations	1002:1025	different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract	1002:1100	Finally, in the third and fourth steps, different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract were added to the solution.
33727184	6	38	theme	officinalis	1077:1087	arg1	extract					1094:1100	Melilotus officinalis (MO) extract	1067:1100	Melilotus officinalis (MO) extract	1067:1100	Finally, in the third and fourth steps, different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract were added to the solution.
33727184	7	39	theme	275 ± 41 nm	1182:1192	arg1	diameter					1170:1177	a mean diameter	1163:1177	a mean diameter of 275 ± 41 nm which is in the required condition for wound caring	1163:1244	The extract contained fibers had a mean diameter of 275 ± 41 nm which is in the required condition for wound caring.
33727184	1	40	theme	electrospinning	202:216	arg1	systems					218:224	electrospinning systems	202:224	electrospinning systems	202:224	Composition of polymers and choosing the type of solvents in electrospinning systems is of great importance to achieve a mat with optimal properties.
33727184	8	41	theme	DSC	1328:1330	arg1	analysis					1418:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	8	42	theme	assays	1377:1382	arg1	analysis					1418:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	8	43	theme	FTIR	1322:1325	arg1	analysis					1418:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	1	44	theme	great	232:236	arg1	importance					238:247	great importance	232:247	great importance	232:247	Composition of polymers and choosing the type of solvents in electrospinning systems is of great importance to achieve a mat with optimal properties.
33727184	0	45	theme	/chitosan/Melilotus	45:63	arg1	electrospun					85:95	poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun	23:95	poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun	23:95	Step-by-step design of poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun nanofibers for wound dressing applications.
33727184	8	46	theme	PCL/CN	1273:1278	arg1	specimens					1294:1302	the optimized PCL/CN and PCL/CN/MO specimens	1259:1302	the optimized PCL/CN and PCL/CN/MO specimens	1259:1302	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	3	47	theme	/dichloromethane	615:630	arg1	compositions					583:594	different compositions	573:594	different compositions of formic acid (FA)/dichloromethane (DCM)	573:636	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	2	48	theme	novel	341:345	arg1	system					355:360	a novel solvent system	339:360	a novel solvent system	339:360	In this work, with emphasizing the influence of a novel solvent system, an electrospun wound dressing was designed in four steps.
33727184	8	49	theme	release	1410:1416	arg1	analysis					1418:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis	1322:1425	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	8	50	theme	cell	1385:1388	arg1	viability					1390:1398	cell viability	1385:1398	cell viability	1385:1398	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	3	51	theme	different	573:581	arg1	compositions					583:594	different compositions	573:594	different compositions of formic acid (FA)/dichloromethane (DCM)	573:636	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	1	52	with	mat	262:264	arg1	properties					279:288	optimal properties	271:288	optimal properties	271:288	Composition of polymers and choosing the type of solvents in electrospinning systems is of great importance to achieve a mat with optimal properties.
33727184	5	53	theme	PCL	892:894	arg1	concentration					875:887	the concentration	871:887	the concentration of PCL	871:894	In the second step, the concentration of PCL was considered variable to achieve the lowest diameter of fibers.
33727184	4	54	theme	lowest	773:778	arg1	diameter					788:795	lowest average diameter	773:795	lowest average diameter of fibers	773:805	The composition of 80FA/20DCM and distance of 15 cm were selected as optimal conditions by lowest average diameter of fibers and simultaneously good surface uniformity.
33727184	3	55	theme	polymer-solvent	453:467	arg1	interactions					469:480	polymer-solvent interactions	453:480	polymer-solvent interactions	453:480	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	5	56	theme	second	858:863	arg1	step					865:868	the second step	854:868	the second step	854:868	In the second step, the concentration of PCL was considered variable to achieve the lowest diameter of fibers.
33727184	6	57	theme	fourth	988:993	arg1	steps					995:999	the third and fourth steps	974:999	the third and fourth steps	974:999	Finally, in the third and fourth steps, different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract were added to the solution.
33727184	7	58	theme	required	1210:1217	arg1	condition					1219:1227	the required condition	1206:1227	the required condition for wound caring	1206:1244	The extract contained fibers had a mean diameter of 275 ± 41 nm which is in the required condition for wound caring.
33727184	5	59	theme	lowest	935:940	arg1	diameter					942:949	the lowest diameter	931:949	the lowest diameter of fibers	931:959	In the second step, the concentration of PCL was considered variable to achieve the lowest diameter of fibers.
33727184	1	60	theme	polymers	156:163	arg1	Composition					141:151	Composition	141:151	Composition of polymers and choosing the type of solvents in electrospinning systems	141:224	Composition of polymers and choosing the type of solvents in electrospinning systems is of great importance to achieve a mat with optimal properties.
33727184	4	61	theme	80FA/20DCM	701:710	arg1	composition					686:696	The composition	682:696	The composition of 80FA/20DCM and distance of 15 cm	682:732	The composition of 80FA/20DCM and distance of 15 cm were selected as optimal conditions by lowest average diameter of fibers and simultaneously good surface uniformity.
33727184	4	61	theme	80FA/20DCM	701:710	arg1	conditions					759:768	optimal conditions	751:768	optimal conditions	751:768	The composition of 80FA/20DCM and distance of 15 cm were selected as optimal conditions by lowest average diameter of fibers and simultaneously good surface uniformity.
33727184	0	62	theme	extract	77:83	arg1	electrospun					85:95	poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun	23:95	poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun	23:95	Step-by-step design of poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun nanofibers for wound dressing applications.
33727184	6	63	theme	constant	1048:1055	arg1	dosage					1057:1062	constant dosage	1048:1062	constant dosage of Melilotus officinalis (MO) extract	1048:1100	Finally, in the third and fourth steps, different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract were added to the solution.
33727184	3	64	theme	formic	599:604	arg1	acid					606:609	formic acid	599:609	formic acid (FA)/dichloromethane (DCM)	599:636	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	3	64	theme	formic	599:604	arg1	FA					612:613	FA	612:613	FA	612:613	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	6	65	theme	dosage	1057:1062	arg1	concentrations					1012:1025	different concentrations	1002:1025	different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract	1002:1100	Finally, in the third and fourth steps, different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract were added to the solution.
33727184	7	66	theme	mean	1165:1168	arg1	diameter					1170:1177	a mean diameter	1163:1177	a mean diameter of 275 ± 41 nm which is in the required condition for wound caring	1163:1244	The extract contained fibers had a mean diameter of 275 ± 41 nm which is in the required condition for wound caring.
33727184	6	67	theme	third	978:982	arg1	steps					995:999	the third and fourth steps	974:999	the third and fourth steps	974:999	Finally, in the third and fourth steps, different concentrations of chitosan (CN) and constant dosage of Melilotus officinalis (MO) extract were added to the solution.
33727184	0	68	theme	officinalis	65:75	arg1	electrospun					85:95	poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun	23:95	poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun	23:95	Step-by-step design of poly (ε-caprolactone) /chitosan/Melilotus officinalis extract electrospun nanofibers for wound dressing applications.
33727184	8	69	theme	drug	1405:1408	arg1	release					1410:1416	drug release	1405:1416	drug release	1405:1416	Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by FTIR, DSC, Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.
33727184	3	70	theme	acid	606:609	arg1	DCM					633:635	DCM	633:635	DCM	633:635	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	3	70	theme	acid	606:609	arg1	/dichloromethane					615:630	formic acid (FA)/dichloromethane	599:630	formic acid (FA)/dichloromethane (DCM)	599:636	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	3	71	theme	constant	514:521	arg1	polycaprolactone					533:548	polycaprolactone	533:548	polycaprolactone (PCL)	533:554	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	3	71	theme	constant	514:521	arg1	amount					523:528	a constant amount	512:528	a constant amount of polycaprolactone (PCL)	512:554	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
33727184	3	71	theme	constant	514:521	arg1	PCL					551:553	PCL	551:553	PCL	551:553	Firstly, to study the effect of polymer-solvent interactions and electrospinning distance, a constant amount of polycaprolactone (PCL) was dissolved at different compositions of formic acid (FA)/dichloromethane (DCM) and was electrospun at different distances.
34932298	1	0	theme	gut	134:136	arg1	microbiome					138:147	the gut microbiome	130:147	the gut microbiome	130:147	There is a bi-directional connection between the gut microbiome and the brain.
34932298	6	1	theme	dysbiosis	623:631	arg1	elimination					608:618	the elimination	604:618	the elimination of dysbiosis	604:631	Antidepressants therapy should be accompanied by the elimination of dysbiosis.
34932298	0	2	theme	depression	60:69	arg1	treatment					47:55	the treatment	43:55	the treatment of depression and anxiety	43:81	[Gut microbiome as a therapeutic target in the treatment of depression and anxiety].
34932298	9	3	theme	microbiome	817:826	arg1	composition					828:838	microbiome composition	817:838	microbiome composition	817:838	The manipulation of microbiome composition has been shown to have great therapeutic potential in the treatment of depression and anxiety.
34932298	7	4	theme	faecal	686:691	arg1	transplantation					704:718	faecal microbiota transplantation	686:718	faecal microbiota transplantation	686:718	For these purposes diet, prebiotics, probiotics and faecal microbiota transplantation can be used.
34932298	7	5	theme	microbiota	693:702	arg1	transplantation					704:718	faecal microbiota transplantation	686:718	faecal microbiota transplantation	686:718	For these purposes diet, prebiotics, probiotics and faecal microbiota transplantation can be used.
34932298	9	6	theme	composition	828:838	arg1	manipulation					801:812	The manipulation	797:812	The manipulation of microbiome composition	797:838	The manipulation of microbiome composition has been shown to have great therapeutic potential in the treatment of depression and anxiety.
34932298	0	7	theme	anxiety	75:81	arg1	treatment					47:55	the treatment	43:55	the treatment of depression and anxiety	43:81	[Gut microbiome as a therapeutic target in the treatment of depression and anxiety].
34932298	2	8	theme	stress	244:249	arg1	response					251:258	the stress response	240:258	the stress response involved in the pathogenesis of depression	240:301	Changes in the composition of the microbiome affect emotions, behavior, and the stress response involved in the pathogenesis of depression.
34932298	0	9	from	target	33:38	arg1	treatment					47:55	the treatment	43:55	the treatment of depression and anxiety	43:81	[Gut microbiome as a therapeutic target in the treatment of depression and anxiety].
34932298	5	10	theme	vicious	488:494	arg1	circle					496:501	This vicious circle	483:501	This vicious circle	483:501	This vicious circle may be responsible for the formation of depression.
34932298	7	11	used	used	727:730	arg2	diet					653:656	diet	653:656	diet	653:656	For these purposes diet, prebiotics, probiotics and faecal microbiota transplantation can be used.
34932298	7	11	used	used	727:730	arg2	transplantation					704:718	faecal microbiota transplantation	686:718	faecal microbiota transplantation	686:718	For these purposes diet, prebiotics, probiotics and faecal microbiota transplantation can be used.
34932298	7	11	used	used	727:730	arg2	probiotics					671:680	probiotics	671:680	probiotics	671:680	For these purposes diet, prebiotics, probiotics and faecal microbiota transplantation can be used.
34932298	7	11	used	used	727:730	arg2	prebiotics					659:668	prebiotics	659:668	prebiotics	659:668	For these purposes diet, prebiotics, probiotics and faecal microbiota transplantation can be used.
34932298	6	12	dep	Antidepressants	555:569	arg1	therapy					571:577	therapy	571:577	Antidepressants therapy	555:577	Antidepressants therapy should be accompanied by the elimination of dysbiosis.
34932298	9	13	contain	have	858:861	arg2	potential					881:889	great therapeutic potential	863:889	great therapeutic potential	863:889	The manipulation of microbiome composition has been shown to have great therapeutic potential in the treatment of depression and anxiety.
34932298	9	13	contain	have	858:861	arg1	manipulation					801:812	The manipulation	797:812	The manipulation of microbiome composition	797:838	The manipulation of microbiome composition has been shown to have great therapeutic potential in the treatment of depression and anxiety.
34932298	4	14	dep	and	467:469	arg1	versa					476:480	versa	476:480	versa	476:480	Dysbiosis enhances stress response and low-grade systemic inflammation, and vice versa.
34932298	9	15	theme	therapeutic	869:879	arg1	potential					881:889	great therapeutic potential	863:889	great therapeutic potential	863:889	The manipulation of microbiome composition has been shown to have great therapeutic potential in the treatment of depression and anxiety.
34932298	4	16	theme	low-grade	434:442	arg1	inflammation					453:464	low-grade systemic inflammation	434:464	low-grade systemic inflammation	434:464	Dysbiosis enhances stress response and low-grade systemic inflammation, and vice versa.
34932298	0	17	theme	therapeutic	21:31	arg1	target					33:38	a therapeutic target	19:38	a therapeutic target in the treatment of depression and anxiety	19:81	[Gut microbiome as a therapeutic target in the treatment of depression and anxiety].
34932298	8	18	dep	advantages	737:746	arg1	The					733:735	The	733:735	The	733:735	The advantages and disadvantages of each method are considered.
34932298	2	19	theme	microbiome	198:207	arg1	composition					179:189	the composition	175:189	the composition of the microbiome	175:207	Changes in the composition of the microbiome affect emotions, behavior, and the stress response involved in the pathogenesis of depression.
34932298	3	20	theme	inflammatory	367:378	arg1	disease					386:392	inflammatory bowel disease	367:392	inflammatory bowel disease	367:392	Depression and anxiety are often associated with dysbiosis and inflammatory bowel disease.
34932298	4	21	theme	systemic	444:451	arg1	inflammation					453:464	low-grade systemic inflammation	434:464	low-grade systemic inflammation	434:464	Dysbiosis enhances stress response and low-grade systemic inflammation, and vice versa.
34932298	3	22	theme	bowel	380:384	arg1	disease					386:392	inflammatory bowel disease	367:392	inflammatory bowel disease	367:392	Depression and anxiety are often associated with dysbiosis and inflammatory bowel disease.
34932298	9	23	theme	great	863:867	arg1	potential					881:889	great therapeutic potential	863:889	great therapeutic potential	863:889	The manipulation of microbiome composition has been shown to have great therapeutic potential in the treatment of depression and anxiety.
34932298	5	24	theme	depression	543:552	arg1	formation					530:538	the formation	526:538	the formation of depression	526:552	This vicious circle may be responsible for the formation of depression.
34932298	1	25	theme	bi-directional	96:109	arg1	connection					111:120	a bi-directional connection	94:120	a bi-directional connection between the gut microbiome and the brain	94:161	There is a bi-directional connection between the gut microbiome and the brain.
34932298	9	26	theme	depression	911:920	arg1	treatment					898:906	the treatment	894:906	the treatment of depression and anxiety	894:932	The manipulation of microbiome composition has been shown to have great therapeutic potential in the treatment of depression and anxiety.
34932298	2	27	theme	depression	292:301	arg1	pathogenesis					276:287	the pathogenesis	272:287	the pathogenesis of depression	272:301	Changes in the composition of the microbiome affect emotions, behavior, and the stress response involved in the pathogenesis of depression.
34932298	4	28	theme	stress	414:419	arg1	response					421:428	stress response	414:428	stress response	414:428	Dysbiosis enhances stress response and low-grade systemic inflammation, and vice versa.
34932298	4	29	dep	enhances	405:412	arg1	and					467:469	and	467:469	and	467:469	Dysbiosis enhances stress response and low-grade systemic inflammation, and vice versa.
34932298	9	30	theme	anxiety	926:932	arg1	treatment					898:906	the treatment	894:906	the treatment of depression and anxiety	894:932	The manipulation of microbiome composition has been shown to have great therapeutic potential in the treatment of depression and anxiety.
34932298	8	31	theme	method	774:779	arg1	advantages					737:746	advantages	737:746	advantages	737:746	The advantages and disadvantages of each method are considered.
34932298	8	31	theme	method	774:779	arg1	disadvantages					752:764	disadvantages	752:764	disadvantages	752:764	The advantages and disadvantages of each method are considered.
34932298	2	32	from	Changes	164:170	arg1	composition					179:189	the composition	175:189	the composition of the microbiome	175:207	Changes in the composition of the microbiome affect emotions, behavior, and the stress response involved in the pathogenesis of depression.
32217362	0	0	theme	chromatography-Mass	89:107	arg1	spectrometry					109:120	offline liquid chromatography-Mass spectrometry	74:120	offline liquid chromatography-Mass spectrometry	74:120	Preparation of O-Glycopeptides from commercial bovine whey proteins using offline liquid chromatography-Mass spectrometry.
32217362	5	1	theme	type	769:772	arg1	moieties					781:788	disialyl core 1 type and core 2 type glycan moieties	737:788	disialyl core 1 type and core 2 type glycan moieties	737:788	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	2	2	theme	O-glycopeptides	367:381	arg1	preparation					352:362	the preparation	348:362	the preparation of O-glycopeptides	348:381	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	0	3	theme	liquid	82:87	arg1	spectrometry					109:120	offline liquid chromatography-Mass spectrometry	74:120	offline liquid chromatography-Mass spectrometry	74:120	Preparation of O-Glycopeptides from commercial bovine whey proteins using offline liquid chromatography-Mass spectrometry.
32217362	3	4	contain	carrying	463:470	arg1	glycoproteins					449:461	many glycoproteins	444:461	many glycoproteins carrying N-glycans and O-glycans	444:494	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	3	4	contain	carrying	463:470	arg2	O-glycans					486:494	O-glycans	486:494	O-glycans	486:494	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	3	4	contain	carrying	463:470	arg2	N-glycans					472:480	N-glycans	472:480	N-glycans	472:480	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	3	5	theme	protein	531:537	arg1	products					539:546	commercial whey protein products	515:546	commercial whey protein products	515:546	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	8	6	theme	O-glycans	1404:1412	arg1	variety					1393:1399	a variety	1391:1399	a variety of O-glycans	1391:1412	O-Glycopeptides bearing a variety of O-glycans could be used as a substrate for endo-α-N-acetyl galactosaminidase, and their various O-glycan structures were useful for the investigation of enzyme activities.
32217362	8	6	theme	O-glycans	1404:1412	arg1	O-glycans					1404:1412	O-glycans	1404:1412	O-glycans	1404:1412	O-Glycopeptides bearing a variety of O-glycans could be used as a substrate for endo-α-N-acetyl galactosaminidase, and their various O-glycan structures were useful for the investigation of enzyme activities.
32217362	5	7	theme	core	746:749	arg1	type					753:756	disialyl core 1 type	737:756	disialyl core 1 type	737:756	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	8	8	used	used	1423:1426	arg2	O-Glycopeptides					1367:1381	O-Glycopeptides	1367:1381	O-Glycopeptides bearing a variety of O-glycans	1367:1412	O-Glycopeptides bearing a variety of O-glycans could be used as a substrate for endo-α-N-acetyl galactosaminidase, and their various O-glycan structures were useful for the investigation of enzyme activities.
32217362	8	8	used	used	1423:1426	arg2	substrate					1433:1441	a substrate	1431:1441	a substrate for endo-α-N-acetyl galactosaminidase	1431:1479	O-Glycopeptides bearing a variety of O-glycans could be used as a substrate for endo-α-N-acetyl galactosaminidase, and their various O-glycan structures were useful for the investigation of enzyme activities.
32217362	7	9	theme	tandem	1269:1274	arg1	spectrometry					1281:1292	tandem mass spectrometry	1269:1292	tandem mass spectrometry	1269:1292	The O-glycopeptides were detected and identified by flow injection analysis combined with electrospray ionization mass spectrometry and tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation.
32217362	6	10	theme	several	1018:1024	arg1	kinds					1026:1030	several kinds	1018:1030	several kinds of O-glycopeptides	1018:1049	We were able to isolate several kinds of O-glycopeptides from lactophorin and κ-casein: six peptide sequences and five kinds of O-glycans.
32217362	5	11	theme	liquid	958:963	arg1	chromatography					965:978	sequential high-performance liquid chromatography	930:978	sequential high-performance liquid chromatography	930:978	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	0	12	from	proteins	59:66	arg1	Preparation					0:10	Preparation	0:10	Preparation of O-Glycopeptides from commercial bovine whey proteins using offline liquid chromatography-Mass spectrometry.	0:121	Preparation of O-Glycopeptides from commercial bovine whey proteins using offline liquid chromatography-Mass spectrometry.
32217362	7	13	theme	mass	1276:1279	arg1	spectrometry					1281:1292	tandem mass spectrometry	1269:1292	tandem mass spectrometry	1269:1292	The O-glycopeptides were detected and identified by flow injection analysis combined with electrospray ionization mass spectrometry and tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation.
32217362	3	14	theme	whey	526:529	arg1	products					539:546	commercial whey protein products	515:546	commercial whey protein products	515:546	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	4	15	theme	several	619:625	arg1	O-glycans					627:635	several O-glycans	619:635	several O-glycans	619:635	In particular, κ-casein glycomacropeptide and lactophorin, which have several O-glycans, are known to exist in whey protein.
32217362	5	16	theme	type	753:756	arg1	moieties					781:788	disialyl core 1 type and core 2 type glycan moieties	737:788	disialyl core 1 type and core 2 type glycan moieties	737:788	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	6	17	theme	O-glycans	1122:1130	arg1	sequences					1094:1102	six peptide sequences	1082:1102	six peptide sequences	1082:1102	We were able to isolate several kinds of O-glycopeptides from lactophorin and κ-casein: six peptide sequences and five kinds of O-glycans.
32217362	6	17	theme	O-glycans	1122:1130	arg1	kinds					1113:1117	five kinds	1108:1117	five kinds of O-glycans	1108:1130	We were able to isolate several kinds of O-glycopeptides from lactophorin and κ-casein: six peptide sequences and five kinds of O-glycans.
32217362	2	18	theme	animal	295:300	arg1	feed					302:305	animal feed	295:305	animal feed	295:305	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	5	19	theme	enzymatic	875:883	arg1	digestion					885:893	enzymatic digestion	875:893	enzymatic digestion (with trypsin or thermolysin)	875:923	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	5	20	theme	available	808:816	arg1	products					831:838	commercially available whey protein products	795:838	commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification	795:991	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	7	21	theme	flow	1185:1188	arg1	analysis					1200:1207	flow injection analysis	1185:1207	flow injection analysis combined with electrospray ionization mass spectrometry and tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation	1185:1364	The O-glycopeptides were detected and identified by flow injection analysis combined with electrospray ionization mass spectrometry and tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation.
32217362	5	22	theme	protein	823:829	arg1	products					831:838	commercially available whey protein products	795:838	commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification	795:991	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	8	23	theme	various	1492:1498	arg1	structures					1509:1518	their various O-glycan structures	1486:1518	their various O-glycan structures	1486:1518	O-Glycopeptides bearing a variety of O-glycans could be used as a substrate for endo-α-N-acetyl galactosaminidase, and their various O-glycan structures were useful for the investigation of enzyme activities.
32217362	4	24	theme	κ-casein	564:571	arg1	glycomacropeptide					573:589	κ-casein glycomacropeptide	564:589	κ-casein glycomacropeptide	564:589	In particular, κ-casein glycomacropeptide and lactophorin, which have several O-glycans, are known to exist in whey protein.
32217362	5	25	theme	whey	818:821	arg1	products					831:838	commercially available whey protein products	795:838	commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification	795:991	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	5	26	theme	glycan	774:779	arg1	moieties					781:788	disialyl core 1 type and core 2 type glycan moieties	737:788	disialyl core 1 type and core 2 type glycan moieties	737:788	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	6	27	gly	O-glycopeptides	1035:1049	arg2	O-glycopeptides					1035:1049	O-glycopeptides	1035:1049	O-glycopeptides	1035:1049	We were able to isolate several kinds of O-glycopeptides from lactophorin and κ-casein: six peptide sequences and five kinds of O-glycans.
32217362	5	28	theme	core	762:765	arg1	type					769:772	core 2 type	762:772	core 2 type	762:772	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	2	29	theme	available	325:333	arg1	resource					335:342	a readily available resource	315:342	a readily available resource for the preparation of O-glycopeptides	315:381	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	3	30	theme	bovine	411:416	arg1	milk					418:421	bovine milk	411:421	bovine milk	411:421	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	7	31	theme	injection	1190:1198	arg1	analysis					1200:1207	flow injection analysis	1185:1207	flow injection analysis combined with electrospray ionization mass spectrometry and tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation	1185:1364	The O-glycopeptides were detected and identified by flow injection analysis combined with electrospray ionization mass spectrometry and tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation.
32217362	8	32	theme	endo-α-N-acetyl	1447:1461	arg1	galactosaminidase					1463:1479	endo-α-N-acetyl galactosaminidase	1447:1479	endo-α-N-acetyl galactosaminidase	1447:1479	O-Glycopeptides bearing a variety of O-glycans could be used as a substrate for endo-α-N-acetyl galactosaminidase, and their various O-glycan structures were useful for the investigation of enzyme activities.
32217362	1	33	theme	purposes	217:224	arg1	purposes					217:224	purposes	217:224	purposes	217:224	O-Glycopeptides derived from natural bioresources are an attractive material for a variety of purposes.
32217362	1	33	theme	purposes	217:224	arg1	variety					206:212	a variety	204:212	a variety of purposes	204:224	O-Glycopeptides derived from natural bioresources are an attractive material for a variety of purposes.
32217362	3	34	theme	protein	388:394	arg1	well-studied					426:437	well-studied	426:437	well-studied	426:437	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	3	34	theme	protein	388:394	arg1	composition					396:406	The protein composition	384:406	The protein composition of bovine milk	384:421	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	5	35	with	extraction	863:872	arg1	thermolysin					912:922	thermolysin	912:922	thermolysin	912:922	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	5	35	with	extraction	863:872	arg1	trypsin					901:907	trypsin	901:907	trypsin	901:907	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	8	36	theme	O-glycan	1500:1507	arg1	structures					1509:1518	their various O-glycan structures	1486:1518	their various O-glycan structures	1486:1518	O-Glycopeptides bearing a variety of O-glycans could be used as a substrate for endo-α-N-acetyl galactosaminidase, and their various O-glycan structures were useful for the investigation of enzyme activities.
32217362	2	37	used	used	253:256	arg2	products					240:247	Whey protein products	227:247	Whey protein products	227:247	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	2	37	used	used	253:256	arg2	supplement					277:286	a human dietary supplement	261:286	a human dietary supplement	261:286	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	5	38	theme	proteose	846:853	arg1	extraction					863:872	proteose peptone extraction	846:872	proteose peptone extraction	846:872	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	0	39	theme	O-Glycopeptides	15:29	arg1	Preparation					0:10	Preparation	0:10	Preparation of O-Glycopeptides from commercial bovine whey proteins using offline liquid chromatography-Mass spectrometry.	0:121	Preparation of O-Glycopeptides from commercial bovine whey proteins using offline liquid chromatography-Mass spectrometry.
32217362	5	40	theme	O-glycopeptides	713:727	arg1	method					703:708	an isolation method	690:708	an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification	690:991	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	5	41	theme	peptone	855:861	arg1	extraction					863:872	proteose peptone extraction	846:872	proteose peptone extraction	846:872	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	0	42	theme	bovine	47:52	arg1	proteins					59:66	commercial bovine whey proteins	36:66	commercial bovine whey proteins using offline liquid chromatography-Mass spectrometry	36:120	Preparation of O-Glycopeptides from commercial bovine whey proteins using offline liquid chromatography-Mass spectrometry.
32217362	3	43	theme	commercial	515:524	arg1	products					539:546	commercial whey protein products	515:546	commercial whey protein products	515:546	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	7	44	theme	electrospray	1223:1234	arg1	spectrometry					1252:1263	electrospray ionization mass spectrometry	1223:1263	electrospray ionization mass spectrometry	1223:1263	The O-glycopeptides were detected and identified by flow injection analysis combined with electrospray ionization mass spectrometry and tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation.
32217362	5	45	theme	disialyl	737:744	arg1	type					753:756	disialyl core 1 type	737:756	disialyl core 1 type	737:756	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	3	46	theme	many	444:447	arg1	glycoproteins					449:461	many glycoproteins	444:461	many glycoproteins carrying N-glycans and O-glycans	444:494	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	0	47	theme	commercial	36:45	arg1	proteins					59:66	commercial bovine whey proteins	36:66	commercial bovine whey proteins using offline liquid chromatography-Mass spectrometry	36:120	Preparation of O-Glycopeptides from commercial bovine whey proteins using offline liquid chromatography-Mass spectrometry.
32217362	2	48	gly	O-glycopeptides	367:381	arg2	O-glycopeptides					367:381	O-glycopeptides	367:381	O-glycopeptides	367:381	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	8	49	theme	activities	1564:1573	arg1	investigation					1540:1552	the investigation	1536:1552	the investigation of enzyme activities	1536:1573	O-Glycopeptides bearing a variety of O-glycans could be used as a substrate for endo-α-N-acetyl galactosaminidase, and their various O-glycan structures were useful for the investigation of enzyme activities.
32217362	4	50	theme	whey	660:663	arg1	protein					665:671	whey protein	660:671	whey protein	660:671	In particular, κ-casein glycomacropeptide and lactophorin, which have several O-glycans, are known to exist in whey protein.
32217362	3	51	theme	milk	418:421	arg1	well-studied					426:437	well-studied	426:437	well-studied	426:437	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	3	51	theme	milk	418:421	arg1	composition					396:406	The protein composition	384:406	The protein composition of bovine milk	384:421	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	8	52	theme	enzyme	1557:1562	arg1	activities					1564:1573	enzyme activities	1557:1573	enzyme activities	1557:1573	O-Glycopeptides bearing a variety of O-glycans could be used as a substrate for endo-α-N-acetyl galactosaminidase, and their various O-glycan structures were useful for the investigation of enzyme activities.
32217362	5	53	gly	O-glycopeptides	713:727	arg2	O-glycopeptides					713:727	O-glycopeptides	713:727	O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification	713:991	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	0	54	theme	whey	54:57	arg1	proteins					59:66	commercial bovine whey proteins	36:66	commercial bovine whey proteins using offline liquid chromatography-Mass spectrometry	36:120	Preparation of O-Glycopeptides from commercial bovine whey proteins using offline liquid chromatography-Mass spectrometry.
32217362	1	55	attach	derived	139:145	arg1	bioresources					160:171	natural bioresources	152:171	natural bioresources	152:171	O-Glycopeptides derived from natural bioresources are an attractive material for a variety of purposes.
32217362	1	55	attach	derived	139:145	arg2	material					191:198	an attractive material	177:198	an attractive material for a variety of purposes	177:224	O-Glycopeptides derived from natural bioresources are an attractive material for a variety of purposes.
32217362	1	55	attach	derived	139:145	arg2	O-Glycopeptides					123:137	O-Glycopeptides	123:137	O-Glycopeptides derived from natural bioresources	123:171	O-Glycopeptides derived from natural bioresources are an attractive material for a variety of purposes.
32217362	7	56	theme	mass	1247:1250	arg1	spectrometry					1252:1263	electrospray ionization mass spectrometry	1223:1263	electrospray ionization mass spectrometry	1223:1263	The O-glycopeptides were detected and identified by flow injection analysis combined with electrospray ionization mass spectrometry and tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation.
32217362	4	57	contain	have	614:617	arg1	lactophorin					595:605	lactophorin	595:605	lactophorin	595:605	In particular, κ-casein glycomacropeptide and lactophorin, which have several O-glycans, are known to exist in whey protein.
32217362	4	57	contain	have	614:617	arg2	O-glycans					627:635	several O-glycans	619:635	several O-glycans	619:635	In particular, κ-casein glycomacropeptide and lactophorin, which have several O-glycans, are known to exist in whey protein.
32217362	4	57	contain	have	614:617	arg1	glycomacropeptide					573:589	κ-casein glycomacropeptide	564:589	κ-casein glycomacropeptide	564:589	In particular, κ-casein glycomacropeptide and lactophorin, which have several O-glycans, are known to exist in whey protein.
32217362	1	58	theme	natural	152:158	arg1	bioresources					160:171	natural bioresources	152:171	natural bioresources	152:171	O-Glycopeptides derived from natural bioresources are an attractive material for a variety of purposes.
32217362	7	59	theme	electron	1335:1342	arg1	dissociation					1353:1364	electron transfer dissociation	1335:1364	electron transfer dissociation	1335:1364	The O-glycopeptides were detected and identified by flow injection analysis combined with electrospray ionization mass spectrometry and tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation.
32217362	5	60	theme	isolation	693:701	arg1	method					703:708	an isolation method	690:708	an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification	690:991	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	2	61	theme	protein	232:238	arg1	supplement					277:286	a human dietary supplement	261:286	a human dietary supplement	261:286	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	2	61	theme	protein	232:238	arg1	products					240:247	Whey protein products	227:247	Whey protein products	227:247	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	5	62	dep	extraction	863:872	arg1	purification					980:991	purification	980:991	purification	980:991	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	5	63	theme	sequential	930:939	arg1	chromatography					965:978	sequential high-performance liquid chromatography	930:978	sequential high-performance liquid chromatography	930:978	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	5	64	with	chromatography	965:978	arg1	thermolysin					912:922	thermolysin	912:922	thermolysin	912:922	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	5	64	with	chromatography	965:978	arg1	trypsin					901:907	trypsin	901:907	trypsin	901:907	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	5	65	with	digestion	885:893	arg1	thermolysin					912:922	thermolysin	912:922	thermolysin	912:922	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	5	65	with	digestion	885:893	arg1	trypsin					901:907	trypsin	901:907	trypsin	901:907	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	2	66	theme	Whey	227:230	arg1	supplement					277:286	a human dietary supplement	261:286	a human dietary supplement	261:286	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	2	66	theme	Whey	227:230	arg1	products					240:247	Whey protein products	227:247	Whey protein products	227:247	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	3	67	gly	glycoproteins	449:461	arg1	glycoproteins					449:461	many glycoproteins	444:461	many glycoproteins carrying N-glycans and O-glycans	444:494	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	5	68	theme	high-performance	941:956	arg1	chromatography					965:978	sequential high-performance liquid chromatography	930:978	sequential high-performance liquid chromatography	930:978	Here, we report an isolation method of O-glycopeptides bearing disialyl core 1 type and core 2 type glycan moieties from commercially available whey protein products using proteose peptone extraction, enzymatic digestion (with trypsin or thermolysin), and sequential high-performance liquid chromatography purification.
32217362	7	69	theme	transfer	1344:1351	arg1	dissociation					1353:1364	electron transfer dissociation	1335:1364	electron transfer dissociation	1335:1364	The O-glycopeptides were detected and identified by flow injection analysis combined with electrospray ionization mass spectrometry and tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation.
32217362	0	70	theme	offline	74:80	arg1	spectrometry					109:120	offline liquid chromatography-Mass spectrometry	74:120	offline liquid chromatography-Mass spectrometry	74:120	Preparation of O-Glycopeptides from commercial bovine whey proteins using offline liquid chromatography-Mass spectrometry.
32217362	7	71	gly	O-glycopeptides	1137:1151	arg2	O-glycopeptides					1137:1151	The O-glycopeptides	1133:1151	The O-glycopeptides	1133:1151	The O-glycopeptides were detected and identified by flow injection analysis combined with electrospray ionization mass spectrometry and tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation.
32217362	2	72	theme	dietary	269:275	arg1	supplement					277:286	a human dietary supplement	261:286	a human dietary supplement	261:286	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	2	72	theme	dietary	269:275	arg1	products					240:247	Whey protein products	227:247	Whey protein products	227:247	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	6	73	theme	peptide	1086:1092	arg1	sequences					1094:1102	six peptide sequences	1082:1102	six peptide sequences	1082:1102	We were able to isolate several kinds of O-glycopeptides from lactophorin and κ-casein: six peptide sequences and five kinds of O-glycans.
32217362	7	74	theme	ionization	1236:1245	arg1	spectrometry					1252:1263	electrospray ionization mass spectrometry	1223:1263	electrospray ionization mass spectrometry	1223:1263	The O-glycopeptides were detected and identified by flow injection analysis combined with electrospray ionization mass spectrometry and tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation.
32217362	2	75	theme	human	263:267	arg1	supplement					277:286	a human dietary supplement	261:286	a human dietary supplement	261:286	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	2	75	theme	human	263:267	arg1	products					240:247	Whey protein products	227:247	Whey protein products	227:247	Whey protein products are used as a human dietary supplement and in animal feed and are a readily available resource for the preparation of O-glycopeptides.
32217362	3	76	located	found	506:510	arg1	products					539:546	commercial whey protein products	515:546	commercial whey protein products	515:546	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	3	76	located	found	506:510	arg2	glycoproteins					449:461	many glycoproteins	444:461	many glycoproteins carrying N-glycans and O-glycans	444:494	The protein composition of bovine milk is well-studied, and many glycoproteins carrying N-glycans and O-glycans have been found in commercial whey protein products.
32217362	1	77	theme	attractive	180:189	arg1	O-Glycopeptides					123:137	O-Glycopeptides	123:137	O-Glycopeptides derived from natural bioresources	123:171	O-Glycopeptides derived from natural bioresources are an attractive material for a variety of purposes.
32217362	1	77	theme	attractive	180:189	arg1	material					191:198	an attractive material	177:198	an attractive material for a variety of purposes	177:224	O-Glycopeptides derived from natural bioresources are an attractive material for a variety of purposes.
32217362	7	78	theme	collision-induced	1300:1316	arg1	dissociation					1318:1329	collision-induced dissociation	1300:1329	collision-induced dissociation	1300:1329	The O-glycopeptides were detected and identified by flow injection analysis combined with electrospray ionization mass spectrometry and tandem mass spectrometry using collision-induced dissociation and electron transfer dissociation.
32217362	6	79	theme	O-glycopeptides	1035:1049	arg1	kinds					1026:1030	several kinds	1018:1030	several kinds of O-glycopeptides	1018:1049	We were able to isolate several kinds of O-glycopeptides from lactophorin and κ-casein: six peptide sequences and five kinds of O-glycans.
31612908	6	0	theme	HMO	673:675	arg1	composition					677:687	HMO composition	673:687	HMO composition of human milk	673:701	So far, only a few human studies have examined HMO composition of human milk in association with the infant's concurrent anthropometry or subsequent growth in infancy, with conflicting results.
31612908	8	1	theme	humans	1043:1048	arg1	microbiome					1014:1023	the gut microbiome	1006:1023	the gut microbiome of lean and obese humans	1006:1048	Moreover, there are differences in the gut microbiome of lean and obese humans, and there is some evidence that the early composition of the gut microbiome can predict later obesity.
31612908	9	2	theme	obesity	1310:1316	arg1	prevention					1318:1327	obesity prevention	1310:1327	obesity prevention	1310:1327	Although it seems that HMOs might have a role in infant growth and adiposity, there is not enough consistent evidence to understand their potential role in obesity prevention.
31612908	6	3	with	association	706:716	arg1	anthropometry					747:759	the infant's concurrent anthropometry	723:759	the infant's concurrent anthropometry	723:759	So far, only a few human studies have examined HMO composition of human milk in association with the infant's concurrent anthropometry or subsequent growth in infancy, with conflicting results.
31612908	6	3	with	association	706:716	arg1	growth					775:780	subsequent growth	764:780	subsequent growth	764:780	So far, only a few human studies have examined HMO composition of human milk in association with the infant's concurrent anthropometry or subsequent growth in infancy, with conflicting results.
31612908	4	4	theme	gut	488:490	arg1	microbiome					492:501	the infant gut microbiome	477:501	the infant gut microbiome	477:501	These complex sugars are thought to contribute to the development of the infant gut microbiome and immune system.
31612908	8	5	theme	gut	1010:1012	arg1	microbiome					1014:1023	the gut microbiome	1006:1023	the gut microbiome of lean and obese humans	1006:1048	Moreover, there are differences in the gut microbiome of lean and obese humans, and there is some evidence that the early composition of the gut microbiome can predict later obesity.
31612908	8	6	theme	later	1139:1143	arg1	obesity					1145:1151	later obesity	1139:1151	later obesity	1139:1151	Moreover, there are differences in the gut microbiome of lean and obese humans, and there is some evidence that the early composition of the gut microbiome can predict later obesity.
31612908	7	7	theme	bacteria	937:944	arg1	growth					918:923	the growth	914:923	the growth of specific bacteria, such as bifidobacteria	914:968	However, HMOs have been shown to modulate the gut microbiome profile by selectively promoting the growth of specific bacteria, such as bifidobacteria.
31612908	10	8	theme	long-term	1482:1490	arg1	health					1492:1497	long-term health	1482:1497	long-term health	1482:1497	More data, particularly from large or longitudinal studies, are needed to clarify the functions of HMOs and other breast-milk components in determining long-term health.
31612908	4	9	theme	infant	481:486	arg1	microbiome					492:501	the infant gut microbiome	477:501	the infant gut microbiome	477:501	These complex sugars are thought to contribute to the development of the infant gut microbiome and immune system.
31612908	5	10	theme	potential	565:573	arg1	link					575:578	a potential link	563:578	a potential link between breastfeeding and lower obesity risk	563:623	Recently, they have been investigated as a potential link between breastfeeding and lower obesity risk.
31612908	5	10	theme	potential	565:573	arg1	they					532:535	they	532:535	they	532:535	Recently, they have been investigated as a potential link between breastfeeding and lower obesity risk.
31612908	7	11	theme	specific	928:935	arg1	bacteria					937:944	specific bacteria	928:944	specific bacteria	928:944	However, HMOs have been shown to modulate the gut microbiome profile by selectively promoting the growth of specific bacteria, such as bifidobacteria.
31612908	7	11	theme	specific	928:935	arg1	bifidobacteria					955:968	bifidobacteria	955:968	bifidobacteria	955:968	However, HMOs have been shown to modulate the gut microbiome profile by selectively promoting the growth of specific bacteria, such as bifidobacteria.
31612908	9	12	theme	infant	1203:1208	arg1	growth					1210:1215	infant growth	1203:1215	infant growth	1203:1215	Although it seems that HMOs might have a role in infant growth and adiposity, there is not enough consistent evidence to understand their potential role in obesity prevention.
31612908	3	13	theme	human	339:343	arg1	milk					345:348	human milk	339:348	human milk	339:348	Human milk oligosaccharides (HMOs) are abundant in human milk and not present in commercially available infant formula.
31612908	3	14	from	milk	345:348	arg1	abundant					327:334	abundant	327:334	abundant	327:334	Human milk oligosaccharides (HMOs) are abundant in human milk and not present in commercially available infant formula.
31612908	8	15	theme	gut	1112:1114	arg1	microbiome					1116:1125	the gut microbiome	1108:1125	the gut microbiome	1108:1125	Moreover, there are differences in the gut microbiome of lean and obese humans, and there is some evidence that the early composition of the gut microbiome can predict later obesity.
31612908	8	16	theme	early	1087:1091	arg1	composition					1093:1103	the early composition	1083:1103	the early composition of the gut microbiome	1083:1125	Moreover, there are differences in the gut microbiome of lean and obese humans, and there is some evidence that the early composition of the gut microbiome can predict later obesity.
31612908	10	17	theme	longitudinal	1368:1379	arg1	studies					1381:1387	large or longitudinal studies	1359:1387	large or longitudinal studies	1359:1387	More data, particularly from large or longitudinal studies, are needed to clarify the functions of HMOs and other breast-milk components in determining long-term health.
31612908	6	18	theme	concurrent	736:745	arg1	anthropometry					747:759	the infant's concurrent anthropometry	723:759	the infant's concurrent anthropometry	723:759	So far, only a few human studies have examined HMO composition of human milk in association with the infant's concurrent anthropometry or subsequent growth in infancy, with conflicting results.
31612908	2	19	theme	association	251:261	arg1	cause					237:241	cause	237:241	cause	237:241	Breastfeeding is thought to be preventive against obesity, but the extent and cause of this association are not well understood.
31612908	2	19	theme	association	251:261	arg1	extent					226:231	extent	226:231	extent	226:231	Breastfeeding is thought to be preventive against obesity, but the extent and cause of this association are not well understood.
31612908	10	20	from	studies	1381:1387	arg1	data					1335:1338	More data	1330:1338	More data	1330:1338	More data, particularly from large or longitudinal studies, are needed to clarify the functions of HMOs and other breast-milk components in determining long-term health.
31612908	3	21	from	present	358:364	arg1	formula					399:405	commercially available infant formula	369:405	commercially available infant formula	369:405	Human milk oligosaccharides (HMOs) are abundant in human milk and not present in commercially available infant formula.
31612908	5	22	theme	lower	606:610	arg1	risk					620:623	lower obesity risk	606:623	lower obesity risk	606:623	Recently, they have been investigated as a potential link between breastfeeding and lower obesity risk.
31612908	10	23	theme	breast-milk	1444:1454	arg1	components					1456:1465	other breast-milk components	1438:1465	other breast-milk components	1438:1465	More data, particularly from large or longitudinal studies, are needed to clarify the functions of HMOs and other breast-milk components in determining long-term health.
31612908	6	24	theme	human	645:649	arg1	studies					651:657	only a few human studies	634:657	only a few human studies	634:657	So far, only a few human studies have examined HMO composition of human milk in association with the infant's concurrent anthropometry or subsequent growth in infancy, with conflicting results.
31612908	8	25	theme	obese	1037:1041	arg1	humans					1043:1048	lean and obese humans	1028:1048	lean and obese humans	1028:1048	Moreover, there are differences in the gut microbiome of lean and obese humans, and there is some evidence that the early composition of the gut microbiome can predict later obesity.
31612908	5	26	theme	obesity	612:618	arg1	risk					620:623	lower obesity risk	606:623	lower obesity risk	606:623	Recently, they have been investigated as a potential link between breastfeeding and lower obesity risk.
31612908	7	27	theme	gut	866:868	arg1	profile					881:887	the gut microbiome profile	862:887	the gut microbiome profile	862:887	However, HMOs have been shown to modulate the gut microbiome profile by selectively promoting the growth of specific bacteria, such as bifidobacteria.
31612908	0	28	theme	Milk	19:22	arg1	Oligosaccharides					24:39	Human Milk Oligosaccharides	13:39	Perspective: Human Milk Oligosaccharides: Fuel for Childhood Obesity Prevention?	0:79	Perspective: Human Milk Oligosaccharides: Fuel for Childhood Obesity Prevention?
31612908	6	29	theme	human	692:696	arg1	milk					698:701	human milk	692:701	human milk	692:701	So far, only a few human studies have examined HMO composition of human milk in association with the infant's concurrent anthropometry or subsequent growth in infancy, with conflicting results.
31612908	7	30	theme	microbiome	870:879	arg1	profile					881:887	the gut microbiome profile	862:887	the gut microbiome profile	862:887	However, HMOs have been shown to modulate the gut microbiome profile by selectively promoting the growth of specific bacteria, such as bifidobacteria.
31612908	6	31	theme	subsequent	764:773	arg1	growth					775:780	subsequent growth	764:780	subsequent growth	764:780	So far, only a few human studies have examined HMO composition of human milk in association with the infant's concurrent anthropometry or subsequent growth in infancy, with conflicting results.
31612908	10	32	theme	large	1359:1363	arg1	studies					1381:1387	large or longitudinal studies	1359:1387	large or longitudinal studies	1359:1387	More data, particularly from large or longitudinal studies, are needed to clarify the functions of HMOs and other breast-milk components in determining long-term health.
31612908	0	33	theme	Human	13:17	arg1	Oligosaccharides					24:39	Human Milk Oligosaccharides	13:39	Perspective: Human Milk Oligosaccharides: Fuel for Childhood Obesity Prevention?	0:79	Perspective: Human Milk Oligosaccharides: Fuel for Childhood Obesity Prevention?
31612908	10	34	theme	other	1438:1442	arg1	components					1456:1465	other breast-milk components	1438:1465	other breast-milk components	1438:1465	More data, particularly from large or longitudinal studies, are needed to clarify the functions of HMOs and other breast-milk components in determining long-term health.
31612908	3	35	theme	available	382:390	arg1	formula					399:405	commercially available infant formula	369:405	commercially available infant formula	369:405	Human milk oligosaccharides (HMOs) are abundant in human milk and not present in commercially available infant formula.
31612908	3	36	from	abundant	327:334	arg1	milk					345:348	human milk	339:348	human milk	339:348	Human milk oligosaccharides (HMOs) are abundant in human milk and not present in commercially available infant formula.
31612908	2	37	dep	extent	226:231	arg1	the					222:224	the	222:224	the	222:224	Breastfeeding is thought to be preventive against obesity, but the extent and cause of this association are not well understood.
31612908	3	38	theme	infant	392:397	arg1	formula					399:405	commercially available infant formula	369:405	commercially available infant formula	369:405	Human milk oligosaccharides (HMOs) are abundant in human milk and not present in commercially available infant formula.
31612908	9	39	theme	consistent	1252:1261	arg1	evidence					1263:1270	enough consistent evidence	1245:1270	enough consistent evidence to understand their potential role in obesity prevention	1245:1327	Although it seems that HMOs might have a role in infant growth and adiposity, there is not enough consistent evidence to understand their potential role in obesity prevention.
31612908	8	40	theme	lean	1028:1031	arg1	humans					1043:1048	lean and obese humans	1028:1048	lean and obese humans	1028:1048	Moreover, there are differences in the gut microbiome of lean and obese humans, and there is some evidence that the early composition of the gut microbiome can predict later obesity.
31612908	8	41	theme	microbiome	1116:1125	arg1	composition					1093:1103	the early composition	1083:1103	the early composition of the gut microbiome	1083:1125	Moreover, there are differences in the gut microbiome of lean and obese humans, and there is some evidence that the early composition of the gut microbiome can predict later obesity.
31612908	8	42	from	differences	991:1001	arg1	microbiome					1014:1023	the gut microbiome	1006:1023	the gut microbiome of lean and obese humans	1006:1048	Moreover, there are differences in the gut microbiome of lean and obese humans, and there is some evidence that the early composition of the gut microbiome can predict later obesity.
31612908	4	43	theme	microbiome	492:501	arg1	development					462:472	the development	458:472	the development of the infant gut microbiome and immune system	458:519	These complex sugars are thought to contribute to the development of the infant gut microbiome and immune system.
31612908	3	44	theme	Human	288:292	arg1	HMOs					317:320	HMOs	317:320	HMOs	317:320	Human milk oligosaccharides (HMOs) are abundant in human milk and not present in commercially available infant formula.
31612908	3	44	theme	Human	288:292	arg1	oligosaccharides					299:314	Human milk oligosaccharides	288:314	Human milk oligosaccharides (HMOs)	288:321	Human milk oligosaccharides (HMOs) are abundant in human milk and not present in commercially available infant formula.
31612908	6	45	theme	conflicting	799:809	arg1	results					811:817	conflicting results	799:817	conflicting results	799:817	So far, only a few human studies have examined HMO composition of human milk in association with the infant's concurrent anthropometry or subsequent growth in infancy, with conflicting results.
31612908	1	46	contain	has	106:108	arg1	Obesity					81:87	Obesity	81:87	Obesity	81:87	Obesity begins early but has lifelong consequences for health and well-being.
31612908	1	46	contain	has	106:108	arg2	consequences					119:130	consequences	119:130	consequences for health and well-being	119:156	Obesity begins early but has lifelong consequences for health and well-being.
31612908	4	47	theme	system	514:519	arg1	development					462:472	the development	458:472	the development of the infant gut microbiome and immune system	458:519	These complex sugars are thought to contribute to the development of the infant gut microbiome and immune system.
31612908	3	48	theme	milk	294:297	arg1	HMOs					317:320	HMOs	317:320	HMOs	317:320	Human milk oligosaccharides (HMOs) are abundant in human milk and not present in commercially available infant formula.
31612908	3	48	theme	milk	294:297	arg1	oligosaccharides					299:314	Human milk oligosaccharides	288:314	Human milk oligosaccharides (HMOs)	288:321	Human milk oligosaccharides (HMOs) are abundant in human milk and not present in commercially available infant formula.
31612908	10	49	theme	components	1456:1465	arg1	functions					1416:1424	the functions	1412:1424	the functions of HMOs and other breast-milk components in determining long-term health	1412:1497	More data, particularly from large or longitudinal studies, are needed to clarify the functions of HMOs and other breast-milk components in determining long-term health.
31612908	4	50	theme	immune	507:512	arg1	system					514:519	immune system	507:519	immune system	507:519	These complex sugars are thought to contribute to the development of the infant gut microbiome and immune system.
31612908	10	51	theme	More	1330:1333	arg1	data					1335:1338	More data	1330:1338	More data	1330:1338	More data, particularly from large or longitudinal studies, are needed to clarify the functions of HMOs and other breast-milk components in determining long-term health.
31612908	6	52	theme	milk	698:701	arg1	composition					677:687	HMO composition	673:687	HMO composition of human milk	673:701	So far, only a few human studies have examined HMO composition of human milk in association with the infant's concurrent anthropometry or subsequent growth in infancy, with conflicting results.
31612908	4	53	theme	complex	414:420	arg1	sugars					422:427	These complex sugars	408:427	These complex sugars	408:427	These complex sugars are thought to contribute to the development of the infant gut microbiome and immune system.
31612908	3	54	from	formula	399:405	arg1	present					358:364	present	358:364	present	358:364	Human milk oligosaccharides (HMOs) are abundant in human milk and not present in commercially available infant formula.
31612908	9	55	theme	potential	1292:1300	arg1	role					1302:1305	their potential role	1286:1305	their potential role in obesity prevention	1286:1327	Although it seems that HMOs might have a role in infant growth and adiposity, there is not enough consistent evidence to understand their potential role in obesity prevention.
31612908	0	56	theme	Obesity	61:67	arg1	Prevention					69:78	Childhood Obesity Prevention	51:78	Childhood Obesity Prevention	51:78	Perspective: Human Milk Oligosaccharides: Fuel for Childhood Obesity Prevention?
31612908	10	57	theme	HMOs	1429:1432	arg1	functions					1416:1424	the functions	1412:1424	the functions of HMOs and other breast-milk components in determining long-term health	1412:1497	More data, particularly from large or longitudinal studies, are needed to clarify the functions of HMOs and other breast-milk components in determining long-term health.
31612908	9	58	from	role	1302:1305	arg1	prevention					1318:1327	obesity prevention	1310:1327	obesity prevention	1310:1327	Although it seems that HMOs might have a role in infant growth and adiposity, there is not enough consistent evidence to understand their potential role in obesity prevention.
31612908	0	59	theme	Childhood	51:59	arg1	Prevention					69:78	Childhood Obesity Prevention	51:78	Childhood Obesity Prevention	51:78	Perspective: Human Milk Oligosaccharides: Fuel for Childhood Obesity Prevention?
31612908	0	60	dep	Perspective	0:10	arg1	Fuel					42:45	Fuel	42:45	Perspective: Human Milk Oligosaccharides: Fuel for Childhood Obesity Prevention?	0:79	Perspective: Human Milk Oligosaccharides: Fuel for Childhood Obesity Prevention?
31612908	0	60	dep	Perspective	0:10	arg1	Oligosaccharides					24:39	Human Milk Oligosaccharides	13:39	Perspective: Human Milk Oligosaccharides: Fuel for Childhood Obesity Prevention?	0:79	Perspective: Human Milk Oligosaccharides: Fuel for Childhood Obesity Prevention?
31612908	9	61	contain	have	1188:1191	arg1	HMOs					1177:1180	HMOs	1177:1180	HMOs	1177:1180	Although it seems that HMOs might have a role in infant growth and adiposity, there is not enough consistent evidence to understand their potential role in obesity prevention.
31612908	9	61	contain	have	1188:1191	arg2	role					1195:1198	a role	1193:1198	a role	1193:1198	Although it seems that HMOs might have a role in infant growth and adiposity, there is not enough consistent evidence to understand their potential role in obesity prevention.
32548717	5	0	theme	gelated	780:786	arg1	templates					797:805	novel freeze gelated chitosan templates	767:805	novel freeze gelated chitosan templates	767:805	Therefore, the purpose of the study was to investigate the drug loading and release characteristics of novel freeze gelated chitosan templates at different percentages of glutaraldehyde.
32548717	13	1	theme	doxycycline-loaded	1717:1734	arg1	templates					1736:1744	These doxycycline-loaded templates	1711:1744	These doxycycline-loaded templates	1711:1744	These doxycycline-loaded templates show their tendency to be used in a functionally graded membrane facing the defect site.
32548717	10	2	theme	chitosan	1343:1350	arg1	region					1364:1369	chitosan fingerprint region	1343:1369	chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile	1343:1451	Fourier transform infrared spectroscopy showed alterations in the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile.
32548717	4	3	theme	tetracycline	581:592	arg1	formulation					552:562	the composite formulation	538:562	the composite formulation of composite and tetracycline when cross-linked with glutaraldehyde	538:630	However, the composite formulation of composite and tetracycline when cross-linked with glutaraldehyde have received little attention.
32548717	0	4	theme	Chitosan	75:82	arg1	Templates					84:92	Chitosan Templates	75:92	Chitosan Templates for Periodontal Tissue Regeneration	75:128	The Effect of Cross-linking Efficiency of Drug-Loaded Novel Freeze Gelated Chitosan Templates for Periodontal Tissue Regeneration.
32548717	2	5	with	templates	403:411	arg1	gradients					457:465	different structural and morphological gradients	418:465	different structural and morphological gradients	418:465	In order to overcome the drawbacks of currently available options, investigators have suggested a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients.
32548717	7	6	theme	templates	1003:1011	arg1	morphology					984:993	porous morphology	977:993	porous morphology of neat templates	977:1011	The electron micrographs depicted porous morphology of neat templates.
32548717	11	7	theme	swelling	1578:1585	arg1	ratio					1587:1591	a swelling ratio	1576:1591	a swelling ratio	1576:1591	Interestingly, swelling profile was not affected by cross-linking either at 0.1 and 1% glutaraldehyde and template showed a swelling ratio of 80%, which gained equilibrium after 15 min.
32548717	0	8	theme	Periodontal	98:108	arg1	Regeneration					117:128	Periodontal Tissue Regeneration	98:128	Periodontal Tissue Regeneration	98:128	The Effect of Cross-linking Efficiency of Drug-Loaded Novel Freeze Gelated Chitosan Templates for Periodontal Tissue Regeneration.
32548717	9	9	contain	had	1145:1147	arg2	%					1157:1157	88 to 92% porosity	1149:1166	88 to 92% porosity	1149:1166	Computerized tomography analysis showed that the templates had 88 to 92% porosity with average pore diameter decreased from 78 to 44.9 μm with increasing concentration.
32548717	9	9	contain	had	1145:1147	arg1	templates					1135:1143	the templates	1131:1143	the templates	1131:1143	Computerized tomography analysis showed that the templates had 88 to 92% porosity with average pore diameter decreased from 78 to 44.9 μm with increasing concentration.
32548717	13	10	theme	graded	1795:1800	arg1	membrane					1802:1809	a functionally graded membrane	1780:1809	a functionally graded membrane facing the defect site	1780:1832	These doxycycline-loaded templates show their tendency to be used in a functionally graded membrane facing the defect site.
32548717	3	11	theme	similar	512:518	arg1	purpose					520:526	similar purpose	512:526	similar purpose	512:526	Chitosan (CH) has been used in the past for similar purpose.
32548717	2	12	theme	available	301:309	arg1	options					311:317	currently available options	291:317	currently available options	291:317	In order to overcome the drawbacks of currently available options, investigators have suggested a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients.
32548717	11	13	theme	%	1598:1598	arg1	ratio					1587:1591	a swelling ratio	1576:1591	a swelling ratio	1576:1591	Interestingly, swelling profile was not affected by cross-linking either at 0.1 and 1% glutaraldehyde and template showed a swelling ratio of 80%, which gained equilibrium after 15 min.
32548717	5	14	theme	release	740:746	arg1	characteristics					748:762	the drug loading and release characteristics	719:762	characteristics	748:762	Therefore, the purpose of the study was to investigate the drug loading and release characteristics of novel freeze gelated chitosan templates at different percentages of glutaraldehyde.
32548717	6	15	theme	doxycycline	922:932	arg1	hyclate					934:940	doxycycline hyclate	922:940	doxycycline hyclate	922:940	These were cross-linked with 0.1 and 1% glutaraldehyde and loaded with doxycycline hyclate.
32548717	10	16	from	alterations	1302:1312	arg1	segment					1332:1338	the glycosidic segment	1317:1338	the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile	1317:1451	Fourier transform infrared spectroscopy showed alterations in the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile.
32548717	10	17	theme	drug	1383:1386	arg1	loading					1388:1394	drug loading	1383:1394	drug loading	1383:1394	Fourier transform infrared spectroscopy showed alterations in the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile.
32548717	4	18	theme	little	646:651	arg1	attention					653:661	little attention	646:661	little attention	646:661	However, the composite formulation of composite and tetracycline when cross-linked with glutaraldehyde have received little attention.
32548717	2	19	theme	templates	403:411	arg1	concept					357:363	a novel concept	349:363	a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients	349:465	In order to overcome the drawbacks of currently available options, investigators have suggested a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients.
32548717	0	20	theme	Tissue	110:115	arg1	Regeneration					117:128	Periodontal Tissue Regeneration	98:128	Periodontal Tissue Regeneration	98:128	The Effect of Cross-linking Efficiency of Drug-Loaded Novel Freeze Gelated Chitosan Templates for Periodontal Tissue Regeneration.
32548717	7	21	theme	porous	977:982	arg1	morphology					984:993	porous morphology	977:993	porous morphology of neat templates	977:1011	The electron micrographs depicted porous morphology of neat templates.
32548717	5	22	theme	chitosan	788:795	arg1	templates					797:805	novel freeze gelated chitosan templates	767:805	novel freeze gelated chitosan templates	767:805	Therefore, the purpose of the study was to investigate the drug loading and release characteristics of novel freeze gelated chitosan templates at different percentages of glutaraldehyde.
32548717	10	23	theme	region	1364:1369	arg1	segment					1332:1338	the glycosidic segment	1317:1338	the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile	1317:1451	Fourier transform infrared spectroscopy showed alterations in the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile.
32548717	2	24	theme	FGM	398:400	arg1	templates					403:411	functionally graded membrane (FGM) templates	368:411	functionally graded membrane (FGM) templates with different structural and morphological gradients	368:465	In order to overcome the drawbacks of currently available options, investigators have suggested a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients.
32548717	5	25	theme	glutaraldehyde	835:848	arg1	percentages					820:830	different percentages	810:830	different percentages of glutaraldehyde	810:848	Therefore, the purpose of the study was to investigate the drug loading and release characteristics of novel freeze gelated chitosan templates at different percentages of glutaraldehyde.
32548717	11	26	dep	affected	1494:1501	arg1	either					1520:1525	either	1520:1525	either	1520:1525	Interestingly, swelling profile was not affected by cross-linking either at 0.1 and 1% glutaraldehyde and template showed a swelling ratio of 80%, which gained equilibrium after 15 min.
32548717	9	27	dep	44.9 μm	1216:1222	arg1	to					1213:1214	to	1213:1214	to	1213:1214	Computerized tomography analysis showed that the templates had 88 to 92% porosity with average pore diameter decreased from 78 to 44.9 μm with increasing concentration.
32548717	1	28	theme	research	205:212	arg1	clusters					214:221	research clusters	205:221	research clusters	205:221	Innovative strategies for periodontal regeneration have been the focus of research clusters across the globe for decades.
32548717	0	29	theme	Cross-linking	14:26	arg1	Efficiency					28:37	Cross-linking Efficiency	14:37	Cross-linking Efficiency of Drug-Loaded Novel Freeze	14:65	The Effect of Cross-linking Efficiency of Drug-Loaded Novel Freeze Gelated Chitosan Templates for Periodontal Tissue Regeneration.
32548717	4	30	theme	composite	542:550	arg1	formulation					552:562	the composite formulation	538:562	the composite formulation of composite and tetracycline when cross-linked with glutaraldehyde	538:630	However, the composite formulation of composite and tetracycline when cross-linked with glutaraldehyde have received little attention.
32548717	12	31	theme	release	1691:1697	arg1	40 μg/mL					1679:1686	a 40 μg/mL	1677:1686	a 40 μg/mL of release	1677:1697	The drug release pattern also showed a 40 μg/mL of release after 24 h.
32548717	7	32	theme	neat	998:1001	arg1	templates					1003:1011	neat templates	998:1011	neat templates	998:1011	The electron micrographs depicted porous morphology of neat templates.
32548717	5	33	theme	different	810:818	arg1	percentages					820:830	different percentages	810:830	different percentages of glutaraldehyde	810:848	Therefore, the purpose of the study was to investigate the drug loading and release characteristics of novel freeze gelated chitosan templates at different percentages of glutaraldehyde.
32548717	9	34	theme	porosity	1159:1166	arg1	%					1157:1157	88 to 92% porosity	1149:1166	88 to 92% porosity	1149:1166	Computerized tomography analysis showed that the templates had 88 to 92% porosity with average pore diameter decreased from 78 to 44.9 μm with increasing concentration.
32548717	1	35	theme	clusters	214:221	arg1	strategies					142:151	Innovative strategies	131:151	Innovative strategies for periodontal regeneration	131:180	Innovative strategies for periodontal regeneration have been the focus of research clusters across the globe for decades.
32548717	1	35	theme	clusters	214:221	arg1	focus					196:200	the focus	192:200	the focus of research clusters across the globe for decades	192:250	Innovative strategies for periodontal regeneration have been the focus of research clusters across the globe for decades.
32548717	2	36	theme	morphological	443:455	arg1	gradients					457:465	different structural and morphological gradients	418:465	different structural and morphological gradients	418:465	In order to overcome the drawbacks of currently available options, investigators have suggested a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients.
32548717	4	37	theme	composite	567:575	arg1	formulation					552:562	the composite formulation	538:562	the composite formulation of composite and tetracycline when cross-linked with glutaraldehyde	538:630	However, the composite formulation of composite and tetracycline when cross-linked with glutaraldehyde have received little attention.
32548717	2	38	theme	options	311:317	arg1	drawbacks					278:286	the drawbacks	274:286	the drawbacks of currently available options	274:317	In order to overcome the drawbacks of currently available options, investigators have suggested a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients.
32548717	2	39	theme	structural	428:437	arg1	gradients					457:465	different structural and morphological gradients	418:465	different structural and morphological gradients	418:465	In order to overcome the drawbacks of currently available options, investigators have suggested a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients.
32548717	5	40	theme	templates	797:805	arg1	characteristics					748:762	the drug loading and release characteristics	719:762	characteristics	748:762	Therefore, the purpose of the study was to investigate the drug loading and release characteristics of novel freeze gelated chitosan templates at different percentages of glutaraldehyde.
32548717	5	40	theme	templates	797:805	arg1	loading					728:734	the drug loading and release characteristics	719:762	loading	728:734	Therefore, the purpose of the study was to investigate the drug loading and release characteristics of novel freeze gelated chitosan templates at different percentages of glutaraldehyde.
32548717	2	41	theme	novel	351:355	arg1	concept					357:363	a novel concept	349:363	a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients	349:465	In order to overcome the drawbacks of currently available options, investigators have suggested a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients.
32548717	5	42	theme	drug	723:726	arg1	loading					728:734	the drug loading and release characteristics	719:762	loading	728:734	Therefore, the purpose of the study was to investigate the drug loading and release characteristics of novel freeze gelated chitosan templates at different percentages of glutaraldehyde.
32548717	10	43	dep	transform	1263:1271	arg1	infrared					1273:1280	infrared	1273:1280	transform infrared spectroscopy	1263:1293	Fourier transform infrared spectroscopy showed alterations in the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile.
32548717	3	44	used	used	491:494	arg2	CH					478:479	CH	478:479	CH	478:479	Chitosan (CH) has been used in the past for similar purpose.
32548717	3	44	used	used	491:494	arg2	Chitosan					468:475	Chitosan	468:475	Chitosan (CH)	468:480	Chitosan (CH) has been used in the past for similar purpose.
32548717	9	45	theme	average	1173:1179	arg1	diameter					1186:1193	average pore diameter	1173:1193	average pore diameter decreased from 78 to 44.9 μm with increasing concentration	1173:1252	Computerized tomography analysis showed that the templates had 88 to 92% porosity with average pore diameter decreased from 78 to 44.9 μm with increasing concentration.
32548717	2	46	theme	different	418:426	arg1	gradients					457:465	different structural and morphological gradients	418:465	different structural and morphological gradients	418:465	In order to overcome the drawbacks of currently available options, investigators have suggested a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients.
32548717	0	47	theme	Efficiency	28:37	arg1	Effect					4:9	The Effect	0:9	The Effect of Cross-linking Efficiency of Drug-Loaded Novel Freeze	0:65	The Effect of Cross-linking Efficiency of Drug-Loaded Novel Freeze Gelated Chitosan Templates for Periodontal Tissue Regeneration.
32548717	11	48	theme	swelling	1469:1476	arg1	profile					1478:1484	swelling profile	1469:1484	swelling profile	1469:1484	Interestingly, swelling profile was not affected by cross-linking either at 0.1 and 1% glutaraldehyde and template showed a swelling ratio of 80%, which gained equilibrium after 15 min.
32548717	8	49	theme	compressed	1058:1067	arg1	ultrastructures					1069:1083	compressed ultrastructures	1058:1083	compressed ultrastructures	1058:1083	After cross-linking, these templates showed compressed ultrastructures.
32548717	9	50	theme	pore	1181:1184	arg1	diameter					1186:1193	average pore diameter	1173:1193	average pore diameter decreased from 78 to 44.9 μm with increasing concentration	1173:1252	Computerized tomography analysis showed that the templates had 88 to 92% porosity with average pore diameter decreased from 78 to 44.9 μm with increasing concentration.
32548717	0	51	theme	Novel	54:58	arg1	Freeze					60:65	Drug-Loaded Novel Freeze	42:65	Drug-Loaded Novel Freeze	42:65	The Effect of Cross-linking Efficiency of Drug-Loaded Novel Freeze Gelated Chitosan Templates for Periodontal Tissue Regeneration.
32548717	5	52	theme	freeze	773:778	arg1	templates					797:805	novel freeze gelated chitosan templates	767:805	novel freeze gelated chitosan templates	767:805	Therefore, the purpose of the study was to investigate the drug loading and release characteristics of novel freeze gelated chitosan templates at different percentages of glutaraldehyde.
32548717	10	53	theme	composite	1435:1443	arg1	profile					1445:1451	a dominant doxycycline spectral composite profile	1403:1451	a dominant doxycycline spectral composite profile	1403:1451	Fourier transform infrared spectroscopy showed alterations in the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile.
32548717	0	54	theme	Drug-Loaded	42:52	arg1	Freeze					60:65	Drug-Loaded Novel Freeze	42:65	Drug-Loaded Novel Freeze	42:65	The Effect of Cross-linking Efficiency of Drug-Loaded Novel Freeze Gelated Chitosan Templates for Periodontal Tissue Regeneration.
32548717	6	55	dep	glutaraldehyde	891:904	arg1	%					889:889	%	889:889	%	889:889	These were cross-linked with 0.1 and 1% glutaraldehyde and loaded with doxycycline hyclate.
32548717	5	56	theme	study	694:698	arg1	purpose					679:685	the purpose	675:685	the purpose of the study	675:698	Therefore, the purpose of the study was to investigate the drug loading and release characteristics of novel freeze gelated chitosan templates at different percentages of glutaraldehyde.
32548717	10	57	theme	spectral	1426:1433	arg1	profile					1445:1451	a dominant doxycycline spectral composite profile	1403:1451	a dominant doxycycline spectral composite profile	1403:1451	Fourier transform infrared spectroscopy showed alterations in the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile.
32548717	1	58	theme	Innovative	131:140	arg1	strategies					142:151	Innovative strategies	131:151	Innovative strategies for periodontal regeneration	131:180	Innovative strategies for periodontal regeneration have been the focus of research clusters across the globe for decades.
32548717	1	58	theme	Innovative	131:140	arg1	focus					196:200	the focus	192:200	the focus of research clusters across the globe for decades	192:250	Innovative strategies for periodontal regeneration have been the focus of research clusters across the globe for decades.
32548717	10	59	theme	glycosidic	1321:1330	arg1	segment					1332:1338	the glycosidic segment	1317:1338	the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile	1317:1451	Fourier transform infrared spectroscopy showed alterations in the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile.
32548717	6	60	dep	%	889:889	arg1	1					888:888	1	888:888	1	888:888	These were cross-linked with 0.1 and 1% glutaraldehyde and loaded with doxycycline hyclate.
32548717	6	60	dep	%	889:889	arg1	0.1					880:882	0.1	880:882	0.1	880:882	These were cross-linked with 0.1 and 1% glutaraldehyde and loaded with doxycycline hyclate.
32548717	1	61	theme	periodontal	157:167	arg1	regeneration					169:180	periodontal regeneration	157:180	periodontal regeneration	157:180	Innovative strategies for periodontal regeneration have been the focus of research clusters across the globe for decades.
32548717	10	62	theme	doxycycline	1414:1424	arg1	profile					1445:1451	a dominant doxycycline spectral composite profile	1403:1451	a dominant doxycycline spectral composite profile	1403:1451	Fourier transform infrared spectroscopy showed alterations in the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile.
32548717	13	63	theme	defect	1822:1827	arg1	site					1829:1832	the defect site	1818:1832	the defect site	1818:1832	These doxycycline-loaded templates show their tendency to be used in a functionally graded membrane facing the defect site.
32548717	7	64	theme	electron	947:954	arg1	micrographs					956:966	The electron micrographs	943:966	The electron micrographs	943:966	The electron micrographs depicted porous morphology of neat templates.
32548717	11	65	dep	%	1539:1539	arg1	1					1538:1538	1	1538:1538	1	1538:1538	Interestingly, swelling profile was not affected by cross-linking either at 0.1 and 1% glutaraldehyde and template showed a swelling ratio of 80%, which gained equilibrium after 15 min.
32548717	11	65	dep	%	1539:1539	arg1	0.1					1530:1532	0.1	1530:1532	0.1	1530:1532	Interestingly, swelling profile was not affected by cross-linking either at 0.1 and 1% glutaraldehyde and template showed a swelling ratio of 80%, which gained equilibrium after 15 min.
32548717	10	66	dep	Fourier	1255:1261	arg1	transform					1263:1271	transform	1263:1271	transform infrared spectroscopy	1263:1293	Fourier transform infrared spectroscopy showed alterations in the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile.
32548717	11	67	dep	glutaraldehyde	1541:1554	arg1	%					1539:1539	%	1539:1539	%	1539:1539	Interestingly, swelling profile was not affected by cross-linking either at 0.1 and 1% glutaraldehyde and template showed a swelling ratio of 80%, which gained equilibrium after 15 min.
32548717	9	68	theme	tomography	1099:1108	arg1	analysis					1110:1117	Computerized tomography analysis	1086:1117	Computerized tomography analysis	1086:1117	Computerized tomography analysis showed that the templates had 88 to 92% porosity with average pore diameter decreased from 78 to 44.9 μm with increasing concentration.
32548717	5	69	theme	novel	767:771	arg1	templates					797:805	novel freeze gelated chitosan templates	767:805	novel freeze gelated chitosan templates	767:805	Therefore, the purpose of the study was to investigate the drug loading and release characteristics of novel freeze gelated chitosan templates at different percentages of glutaraldehyde.
32548717	10	70	theme	dominant	1405:1412	arg1	doxycycline					1414:1424	a dominant doxycycline	1403:1424	a dominant doxycycline spectral composite profile	1403:1451	Fourier transform infrared spectroscopy showed alterations in the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile.
32548717	2	71	theme	membrane	388:395	arg1	templates					403:411	functionally graded membrane (FGM) templates	368:411	functionally graded membrane (FGM) templates with different structural and morphological gradients	368:465	In order to overcome the drawbacks of currently available options, investigators have suggested a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients.
32548717	9	72	theme	Computerized	1086:1097	arg1	analysis					1110:1117	Computerized tomography analysis	1086:1117	Computerized tomography analysis	1086:1117	Computerized tomography analysis showed that the templates had 88 to 92% porosity with average pore diameter decreased from 78 to 44.9 μm with increasing concentration.
32548717	12	73	theme	release	1649:1655	arg1	pattern					1657:1663	The drug release pattern	1640:1663	The drug release pattern	1640:1663	The drug release pattern also showed a 40 μg/mL of release after 24 h.
32548717	0	74	theme	Freeze	60:65	arg1	Efficiency					28:37	Cross-linking Efficiency	14:37	Cross-linking Efficiency of Drug-Loaded Novel Freeze	14:65	The Effect of Cross-linking Efficiency of Drug-Loaded Novel Freeze Gelated Chitosan Templates for Periodontal Tissue Regeneration.
32548717	9	75	dep	%	1157:1157	arg1	to					1152:1153	to	1152:1153	to	1152:1153	Computerized tomography analysis showed that the templates had 88 to 92% porosity with average pore diameter decreased from 78 to 44.9 μm with increasing concentration.
32548717	2	76	theme	graded	381:386	arg1	templates					403:411	functionally graded membrane (FGM) templates	368:411	functionally graded membrane (FGM) templates with different structural and morphological gradients	368:465	In order to overcome the drawbacks of currently available options, investigators have suggested a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients.
32548717	10	77	theme	fingerprint	1352:1362	arg1	region					1364:1369	chitosan fingerprint region	1343:1369	chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile	1343:1451	Fourier transform infrared spectroscopy showed alterations in the glycosidic segment of chitosan fingerprint region which after drug loading showed a dominant doxycycline spectral composite profile.
32548717	12	78	theme	drug	1644:1647	arg1	pattern					1657:1663	The drug release pattern	1640:1663	The drug release pattern	1640:1663	The drug release pattern also showed a 40 μg/mL of release after 24 h.
34818530	7	0	theme	BCH-MMT	1509:1515	arg1	film					1517:1520	a modified BCH-MMT film	1498:1520	a modified BCH-MMT film	1498:1520	Altogether, these findings suggest that a modified BCH-MMT film could serve as scaffolding for skin tissue engineering and potentially as a novel dressing material for pressure injury.
34818530	5	1	theme	SEM	1115:1117	arg1	photographs					1119:1129	SEM photographs	1115:1129	SEM photographs	1115:1129	Both, BC and BCH-MMT, showed a typical FTIR spectrum of cellulosic substrates with pronounces bands around 3344, 2920, 1637, and 1041 cm-1 while microparticles of MMT dispersed uniformly throughout BC were revealed by SEM photographs.
34818530	3	2	theme	Electron	667:674	arg1	SEM					688:690	SEM	688:690	SEM	688:690	Afterward, Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) were used to characterize the bacterial cellulose hydrogel incorporated into montmorillonite (BCH-MMT).
34818530	3	2	theme	Electron	667:674	arg1	Microscopy					676:685	Scanning Electron Microscopy	658:685	Scanning Electron Microscopy (SEM)	658:691	Afterward, Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) were used to characterize the bacterial cellulose hydrogel incorporated into montmorillonite (BCH-MMT).
34818530	6	3	theme	spontaneous	1254:1264	arg1	hyperalgesia					1266:1277	spontaneous hyperalgesia	1254:1277	spontaneous hyperalgesia	1254:1277	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	3	4	dep	Fourier	606:612	arg1	Transform					614:622	Transform	614:622	Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM)	614:691	Afterward, Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) were used to characterize the bacterial cellulose hydrogel incorporated into montmorillonite (BCH-MMT).
34818530	0	5	theme	pressure	87:94	arg1	injury					96:101	pressure injury	87:101	pressure injury	87:101	Modified montmorillonite-bacterial cellulose composites as a novel dressing system for pressure injury.
34818530	5	6	theme	MMT	1060:1062	arg1	microparticles					1042:1055	microparticles	1042:1055	microparticles of MMT dispersed uniformly throughout BC	1042:1096	Both, BC and BCH-MMT, showed a typical FTIR spectrum of cellulosic substrates with pronounces bands around 3344, 2920, 1637, and 1041 cm-1 while microparticles of MMT dispersed uniformly throughout BC were revealed by SEM photographs.
34818530	4	7	theme	injury	810:815	arg1	model					817:821	The pressure injury model	797:821	The pressure injury model	797:821	The pressure injury model was assessed by macroscopic and histological analysis in male Swiss mice.
34818530	3	8	dep	Transform	614:622	arg1	Infrared					624:631	Infrared	624:631	Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM)	614:691	Afterward, Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) were used to characterize the bacterial cellulose hydrogel incorporated into montmorillonite (BCH-MMT).
34818530	6	9	theme	cells	1318:1322	arg1	cells					1318:1322	in-site inflammatory cells	1297:1322	in-site inflammatory cells (to the same level as the positive control Dersani®)	1297:1375	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	9	theme	cells	1318:1322	arg1	amounts					1286:1292	lower amounts	1280:1292	lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®)	1280:1375	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	9	theme	cells	1318:1322	arg1	redness					1242:1248	redness	1242:1248	redness	1242:1248	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	9	theme	cells	1318:1322	arg1	re-epithelialization					1412:1431	complete epidermis re-epithelialization	1393:1431	complete epidermis re-epithelialization	1393:1431	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	9	theme	cells	1318:1322	arg1	area					1234:1237	reduced area	1226:1237	reduced area of redness and spontaneous hyperalgesia	1226:1277	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	9	theme	cells	1318:1322	arg1	hyperalgesia					1266:1277	spontaneous hyperalgesia	1254:1277	spontaneous hyperalgesia	1254:1277	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	9	theme	cells	1318:1322	arg1	regeneration					1444:1455	tissue regeneration	1437:1455	tissue regeneration	1437:1455	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	1	10	theme	pressure	332:339	arg1	model					348:352	pressure injury model	332:352	pressure injury model	332:352	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	6	11	theme	positive	1350:1357	arg1	Dersani®					1367:1374	the positive control Dersani®	1346:1374	the positive control Dersani®	1346:1374	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	1	12	from	effects	160:166	arg1	model					316:320	a skin wound healing mouse model	289:320	a skin wound healing mouse model	289:320	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	7	13	theme	modified	1500:1507	arg1	film					1517:1520	a modified BCH-MMT film	1498:1520	a modified BCH-MMT film	1498:1520	Altogether, these findings suggest that a modified BCH-MMT film could serve as scaffolding for skin tissue engineering and potentially as a novel dressing material for pressure injury.
34818530	6	14	theme	inflammatory	1305:1316	arg1	cells					1318:1322	in-site inflammatory cells	1297:1322	in-site inflammatory cells (to the same level as the positive control Dersani®)	1297:1375	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	1	15	theme	injury	341:346	arg1	model					348:352	pressure injury model	332:352	pressure injury model	332:352	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	2	16	theme	MMT	551:553	arg1	suspension					555:564	a 0.1% MMT suspension	544:564	a 0.1% MMT suspension (100 rpm for 24 h at 28 °C)	544:592	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	7	17	theme	dressing	1604:1611	arg1	material					1613:1620	a novel dressing material	1596:1620	a novel dressing material for pressure injury	1596:1640	Altogether, these findings suggest that a modified BCH-MMT film could serve as scaffolding for skin tissue engineering and potentially as a novel dressing material for pressure injury.
34818530	1	18	theme	underlying	254:263	arg1	mechanisms					265:274	its underlying mechanisms	250:274	its underlying mechanisms	250:274	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	6	19	theme	in-site	1297:1303	arg1	cells					1318:1322	in-site inflammatory cells	1297:1322	in-site inflammatory cells (to the same level as the positive control Dersani®)	1297:1375	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	7	20	theme	skin	1553:1556	arg1	engineering					1565:1575	skin tissue engineering	1553:1575	skin tissue engineering	1553:1575	Altogether, these findings suggest that a modified BCH-MMT film could serve as scaffolding for skin tissue engineering and potentially as a novel dressing material for pressure injury.
34818530	6	21	theme	complete	1393:1400	arg1	re-epithelialization					1412:1431	complete epidermis re-epithelialization	1393:1431	complete epidermis re-epithelialization	1393:1431	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	2	22	theme	circular	441:448	arg1	sheets					475:480	thickness circular bacterial cellulose (BC) sheets	431:480	thickness circular bacterial cellulose (BC) sheets	431:480	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	3	23	theme	Scanning	658:665	arg1	SEM					688:690	SEM	688:690	SEM	688:690	Afterward, Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) were used to characterize the bacterial cellulose hydrogel incorporated into montmorillonite (BCH-MMT).
34818530	3	23	theme	Scanning	658:665	arg1	Microscopy					676:685	Scanning Electron Microscopy	658:685	Scanning Electron Microscopy (SEM)	658:691	Afterward, Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) were used to characterize the bacterial cellulose hydrogel incorporated into montmorillonite (BCH-MMT).
34818530	6	24	theme	ulcers	1200:1205	arg1	healing					1180:1186	significant healing	1168:1186	significant healing of pressure ulcers	1168:1205	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	4	25	theme	macroscopic	839:849	arg1	analysis					868:875	macroscopic and histological analysis	839:875	macroscopic and histological analysis in male Swiss mice	839:894	The pressure injury model was assessed by macroscopic and histological analysis in male Swiss mice.
34818530	1	26	theme	bacterial	171:179	arg1	BCH					201:203	BCH	201:203	BCH	201:203	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	1	26	theme	bacterial	171:179	arg1	hydrogel					191:198	bacterial cellulose hydrogel	171:198	bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT)	171:244	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	0	27	theme	montmorillonite-bacterial	9:33	arg1	system					76:81	a novel dressing system	59:81	a novel dressing system for pressure injury	59:101	Modified montmorillonite-bacterial cellulose composites as a novel dressing system for pressure injury.
34818530	0	27	theme	montmorillonite-bacterial	9:33	arg1	composites					45:54	montmorillonite-bacterial cellulose composites	9:54	montmorillonite-bacterial cellulose composites	9:54	Modified montmorillonite-bacterial cellulose composites as a novel dressing system for pressure injury.
34818530	2	28	theme	BC	471:472	arg1	sheets					475:480	thickness circular bacterial cellulose (BC) sheets	431:480	thickness circular bacterial cellulose (BC) sheets	431:480	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	1	29	from	mechanisms	265:274	arg1	model					316:320	a skin wound healing mouse model	289:320	a skin wound healing mouse model	289:320	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	6	30	theme	significant	1168:1178	arg1	healing					1180:1186	significant healing	1168:1186	significant healing of pressure ulcers	1168:1205	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	2	31	from	28 °C	587:591	arg1	24 h					579:582	24 h	579:582	24 h at 28 °C	579:591	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	1	32	theme	cellulose	181:189	arg1	BCH					201:203	BCH	201:203	BCH	201:203	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	1	32	theme	cellulose	181:189	arg1	hydrogel					191:198	bacterial cellulose hydrogel	171:198	bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT)	171:244	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	4	33	theme	pressure	801:808	arg1	model					817:821	The pressure injury model	797:821	The pressure injury model	797:821	The pressure injury model was assessed by macroscopic and histological analysis in male Swiss mice.
34818530	5	34	theme	pronounces	980:989	arg1	bands					991:995	pronounces bands	980:995	pronounces bands around 3344, 2920, 1637, and 1041 cm-1	980:1034	Both, BC and BCH-MMT, showed a typical FTIR spectrum of cellulosic substrates with pronounces bands around 3344, 2920, 1637, and 1041 cm-1 while microparticles of MMT dispersed uniformly throughout BC were revealed by SEM photographs.
34818530	6	35	theme	lower	1280:1284	arg1	cells					1318:1322	in-site inflammatory cells	1297:1322	in-site inflammatory cells (to the same level as the positive control Dersani®)	1297:1375	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	35	theme	lower	1280:1284	arg1	redness					1242:1248	redness	1242:1248	redness	1242:1248	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	35	theme	lower	1280:1284	arg1	hyperalgesia					1266:1277	spontaneous hyperalgesia	1254:1277	spontaneous hyperalgesia	1254:1277	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	35	theme	lower	1280:1284	arg1	amounts					1286:1292	lower amounts	1280:1292	lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®)	1280:1375	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	1	36	theme	hydrogel	191:198	arg1	mechanisms					265:274	its underlying mechanisms	250:274	its underlying mechanisms	250:274	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	1	36	theme	hydrogel	191:198	arg1	effects					160:166	the effects	156:166	the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT)	156:244	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	7	37	theme	novel	1598:1602	arg1	material					1613:1620	a novel dressing material	1596:1620	a novel dressing material for pressure injury	1596:1640	Altogether, these findings suggest that a modified BCH-MMT film could serve as scaffolding for skin tissue engineering and potentially as a novel dressing material for pressure injury.
34818530	4	38	theme	male	880:883	arg1	mice					891:894	male Swiss mice	880:894	male Swiss mice	880:894	The pressure injury model was assessed by macroscopic and histological analysis in male Swiss mice.
34818530	6	39	theme	reduced	1226:1232	arg1	area					1234:1237	reduced area	1226:1237	reduced area of redness and spontaneous hyperalgesia	1226:1277	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	1	40	theme	main	108:111	arg1	objective					113:121	The main objective	104:121	The main objective of this study	104:135	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	7	41	theme	pressure	1626:1633	arg1	injury					1635:1640	pressure injury	1626:1640	pressure injury	1626:1640	Altogether, these findings suggest that a modified BCH-MMT film could serve as scaffolding for skin tissue engineering and potentially as a novel dressing material for pressure injury.
34818530	0	42	theme	cellulose	35:43	arg1	system					76:81	a novel dressing system	59:81	a novel dressing system for pressure injury	59:101	Modified montmorillonite-bacterial cellulose composites as a novel dressing system for pressure injury.
34818530	0	42	theme	cellulose	35:43	arg1	composites					45:54	montmorillonite-bacterial cellulose composites	9:54	montmorillonite-bacterial cellulose composites	9:54	Modified montmorillonite-bacterial cellulose composites as a novel dressing system for pressure injury.
34818530	1	43	theme	action	279:284	arg1	mechanisms					265:274	its underlying mechanisms	250:274	its underlying mechanisms	250:274	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	1	43	theme	action	279:284	arg1	effects					160:166	the effects	156:166	the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT)	156:244	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	2	44	theme	deposition	519:528	arg1	ex-site					530:536	deposition ex-site	519:536	deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C)	519:592	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	2	45	theme	bacterial	450:458	arg1	sheets					475:480	thickness circular bacterial cellulose (BC) sheets	431:480	thickness circular bacterial cellulose (BC) sheets	431:480	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	2	46	dep	suspension	555:564	arg1	100 rpm					567:573	100 rpm	567:573	100 rpm for 24 h at 28 °C	567:591	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	2	47	theme	cellulose	460:468	arg1	sheets					475:480	thickness circular bacterial cellulose (BC) sheets	431:480	thickness circular bacterial cellulose (BC) sheets	431:480	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	4	48	theme	Swiss	885:889	arg1	mice					891:894	male Swiss mice	880:894	male Swiss mice	880:894	The pressure injury model was assessed by macroscopic and histological analysis in male Swiss mice.
34818530	3	49	used	used	698:701	arg2	Fourier					606:612	Fourier	606:612	Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM)	606:691	Afterward, Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) were used to characterize the bacterial cellulose hydrogel incorporated into montmorillonite (BCH-MMT).
34818530	5	50	theme	cellulosic	953:962	arg1	substrates					964:973	cellulosic substrates	953:973	cellulosic substrates	953:973	Both, BC and BCH-MMT, showed a typical FTIR spectrum of cellulosic substrates with pronounces bands around 3344, 2920, 1637, and 1041 cm-1 while microparticles of MMT dispersed uniformly throughout BC were revealed by SEM photographs.
34818530	7	51	theme	tissue	1558:1563	arg1	engineering					1565:1575	skin tissue engineering	1553:1575	skin tissue engineering	1553:1575	Altogether, these findings suggest that a modified BCH-MMT film could serve as scaffolding for skin tissue engineering and potentially as a novel dressing material for pressure injury.
34818530	0	52	theme	dressing	67:74	arg1	system					76:81	a novel dressing system	59:81	a novel dressing system for pressure injury	59:101	Modified montmorillonite-bacterial cellulose composites as a novel dressing system for pressure injury.
34818530	0	52	theme	dressing	67:74	arg1	composites					45:54	montmorillonite-bacterial cellulose composites	9:54	montmorillonite-bacterial cellulose composites	9:54	Modified montmorillonite-bacterial cellulose composites as a novel dressing system for pressure injury.
34818530	1	53	theme	skin	291:294	arg1	healing					302:308	a skin wound healing	289:308	a skin wound healing mouse model	289:320	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	2	54	theme	%	549:549	arg1	suspension					555:564	a 0.1% MMT suspension	544:564	a 0.1% MMT suspension (100 rpm for 24 h at 28 °C)	544:592	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	5	55	with	spectrum	941:948	arg1	bands					991:995	pronounces bands	980:995	pronounces bands around 3344, 2920, 1637, and 1041 cm-1	980:1034	Both, BC and BCH-MMT, showed a typical FTIR spectrum of cellulosic substrates with pronounces bands around 3344, 2920, 1637, and 1041 cm-1 while microparticles of MMT dispersed uniformly throughout BC were revealed by SEM photographs.
34818530	5	56	theme	substrates	964:973	arg1	spectrum					941:948	a typical FTIR spectrum	926:948	a typical FTIR spectrum of cellulosic substrates with pronounces bands around 3344, 2920, 1637, and 1041 cm-1	926:1034	Both, BC and BCH-MMT, showed a typical FTIR spectrum of cellulosic substrates with pronounces bands around 3344, 2920, 1637, and 1041 cm-1 while microparticles of MMT dispersed uniformly throughout BC were revealed by SEM photographs.
34818530	0	57	theme	novel	61:65	arg1	system					76:81	a novel dressing system	59:81	a novel dressing system for pressure injury	59:101	Modified montmorillonite-bacterial cellulose composites as a novel dressing system for pressure injury.
34818530	0	57	theme	novel	61:65	arg1	composites					45:54	montmorillonite-bacterial cellulose composites	9:54	montmorillonite-bacterial cellulose composites	9:54	Modified montmorillonite-bacterial cellulose composites as a novel dressing system for pressure injury.
34818530	1	58	theme	wound	296:300	arg1	healing					302:308	a skin wound healing	289:308	a skin wound healing mouse model	289:320	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	2	59	theme	0.1	546:548	arg1	%					549:549	%	549:549	%	549:549	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	4	60	from	analysis	868:875	arg1	mice					891:894	male Swiss mice	880:894	male Swiss mice	880:894	The pressure injury model was assessed by macroscopic and histological analysis in male Swiss mice.
34818530	1	61	theme	healing	302:308	arg1	model					316:320	a skin wound healing mouse model	289:320	a skin wound healing mouse model	289:320	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	6	62	theme	redness	1242:1248	arg1	cells					1318:1322	in-site inflammatory cells	1297:1322	in-site inflammatory cells (to the same level as the positive control Dersani®)	1297:1375	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	62	theme	redness	1242:1248	arg1	amounts					1286:1292	lower amounts	1280:1292	lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®)	1280:1375	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	62	theme	redness	1242:1248	arg1	redness					1242:1248	redness	1242:1248	redness	1242:1248	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	62	theme	redness	1242:1248	arg1	re-epithelialization					1412:1431	complete epidermis re-epithelialization	1393:1431	complete epidermis re-epithelialization	1393:1431	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	62	theme	redness	1242:1248	arg1	area					1234:1237	reduced area	1226:1237	reduced area of redness and spontaneous hyperalgesia	1226:1277	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	62	theme	redness	1242:1248	arg1	hyperalgesia					1266:1277	spontaneous hyperalgesia	1254:1277	spontaneous hyperalgesia	1254:1277	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	62	theme	redness	1242:1248	arg1	regeneration					1444:1455	tissue regeneration	1437:1455	tissue regeneration	1437:1455	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	63	theme	pressure	1191:1198	arg1	ulcers					1200:1205	pressure ulcers	1191:1205	pressure ulcers	1191:1205	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	1	64	theme	study	131:135	arg1	objective					113:121	The main objective	104:121	The main objective of this study	104:135	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	6	65	theme	tissue	1437:1442	arg1	regeneration					1444:1455	tissue regeneration	1437:1455	tissue regeneration	1437:1455	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	66	theme	hyperalgesia	1266:1277	arg1	cells					1318:1322	in-site inflammatory cells	1297:1322	in-site inflammatory cells (to the same level as the positive control Dersani®)	1297:1375	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	66	theme	hyperalgesia	1266:1277	arg1	amounts					1286:1292	lower amounts	1280:1292	lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®)	1280:1375	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	66	theme	hyperalgesia	1266:1277	arg1	redness					1242:1248	redness	1242:1248	redness	1242:1248	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	66	theme	hyperalgesia	1266:1277	arg1	re-epithelialization					1412:1431	complete epidermis re-epithelialization	1393:1431	complete epidermis re-epithelialization	1393:1431	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	66	theme	hyperalgesia	1266:1277	arg1	area					1234:1237	reduced area	1226:1237	reduced area of redness and spontaneous hyperalgesia	1226:1277	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	66	theme	hyperalgesia	1266:1277	arg1	hyperalgesia					1266:1277	spontaneous hyperalgesia	1254:1277	spontaneous hyperalgesia	1254:1277	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	6	66	theme	hyperalgesia	1266:1277	arg1	regeneration					1444:1455	tissue regeneration	1437:1455	tissue regeneration	1437:1455	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	4	67	theme	histological	855:866	arg1	analysis					868:875	macroscopic and histological analysis	839:875	macroscopic and histological analysis in male Swiss mice	839:894	The pressure injury model was assessed by macroscopic and histological analysis in male Swiss mice.
34818530	5	68	theme	typical	928:934	arg1	spectrum					941:948	a typical FTIR spectrum	926:948	a typical FTIR spectrum of cellulosic substrates with pronounces bands around 3344, 2920, 1637, and 1041 cm-1	926:1034	Both, BC and BCH-MMT, showed a typical FTIR spectrum of cellulosic substrates with pronounces bands around 3344, 2920, 1637, and 1041 cm-1 while microparticles of MMT dispersed uniformly throughout BC were revealed by SEM photographs.
34818530	2	69	from	5 cm	400:403	arg1	0.8 mm					421:426	0.8 mm	421:426	0.8 mm	421:426	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	2	69	from	5 cm	400:403	arg1	diameter					408:415	diameter	408:415	diameter	408:415	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	6	70	theme	same	1332:1335	arg1	level					1337:1341	the same level	1328:1341	the same level as the positive control Dersani®	1328:1374	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	5	71	theme	FTIR	936:939	arg1	spectrum					941:948	a typical FTIR spectrum	926:948	a typical FTIR spectrum of cellulosic substrates with pronounces bands around 3344, 2920, 1637, and 1041 cm-1	926:1034	Both, BC and BCH-MMT, showed a typical FTIR spectrum of cellulosic substrates with pronounces bands around 3344, 2920, 1637, and 1041 cm-1 while microparticles of MMT dispersed uniformly throughout BC were revealed by SEM photographs.
34818530	2	72	theme	Komagataeibacter	355:370	arg1	hansenii					372:379	Komagataeibacter hansenii	355:379	Komagataeibacter hansenii	355:379	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	3	73	theme	cellulose	733:741	arg1	hydrogel					743:750	the bacterial cellulose hydrogel	719:750	the bacterial cellulose hydrogel incorporated into montmorillonite (BCH-MMT)	719:794	Afterward, Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) were used to characterize the bacterial cellulose hydrogel incorporated into montmorillonite (BCH-MMT).
34818530	2	74	theme	sheets	475:480	arg1	0.8 mm					421:426	0.8 mm	421:426	0.8 mm	421:426	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	2	74	theme	sheets	475:480	arg1	diameter					408:415	diameter	408:415	diameter	408:415	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	1	75	theme	mouse	310:314	arg1	model					316:320	a skin wound healing mouse model	289:320	a skin wound healing mouse model	289:320	The main objective of this study was to investigate the effects of bacterial cellulose hydrogel (BCH) incorporated into montmorillonite (MMT) and its underlying mechanisms of action on a skin wound healing mouse model following pressure injury model.
34818530	6	76	theme	control	1359:1365	arg1	Dersani®					1367:1374	the positive control Dersani®	1346:1374	the positive control Dersani®	1346:1374	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	2	77	used	used	385:388	arg2	hansenii					372:379	Komagataeibacter hansenii	355:379	Komagataeibacter hansenii	355:379	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	2	78	theme	thickness	431:439	arg1	sheets					475:480	thickness circular bacterial cellulose (BC) sheets	431:480	thickness circular bacterial cellulose (BC) sheets	431:480	Komagataeibacter hansenii was used to obtain 5 cm in diameter and 0.8 mm of thickness circular bacterial cellulose (BC) sheets, which were incorporated with MMT by deposition ex-site using a 0.1% MMT suspension (100 rpm for 24 h at 28 °C).
34818530	6	79	theme	epidermis	1402:1410	arg1	re-epithelialization					1412:1431	complete epidermis re-epithelialization	1393:1431	complete epidermis re-epithelialization	1393:1431	Animals treated with BCH-MMT showed significant healing of pressure ulcers as demonstrated by reduced area of redness and spontaneous hyperalgesia, lower amounts of in-site inflammatory cells (to the same level as the positive control Dersani®) and ultimately, complete epidermis re-epithelialization and tissue regeneration.
34818530	3	80	theme	bacterial	723:731	arg1	hydrogel					743:750	the bacterial cellulose hydrogel	719:750	the bacterial cellulose hydrogel incorporated into montmorillonite (BCH-MMT)	719:794	Afterward, Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) were used to characterize the bacterial cellulose hydrogel incorporated into montmorillonite (BCH-MMT).
34936761	10	0	theme	reasonable	1940:1949	arg1	agreement					1951:1959	a reasonable agreement	1938:1959	a reasonable agreement with the experiments	1938:1980	The model reproduces both bundle size and pore size distribution in a reasonable agreement with the experiments.
34936761	3	1	theme	gelation	505:512	arg1	mechanism					514:522	the gelation mechanism	501:522	the gelation mechanism	501:522	In order to improve understanding of the gelation mechanism in aqueous solution, this work presents a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels, similarly to an extremely coarse-grained molecular dynamics (MD) approach.
34936761	3	2	theme	dynamics	723:730	arg1	approach					737:744	an extremely coarse-grained molecular dynamics (MD) approach	685:744	an extremely coarse-grained molecular dynamics (MD) approach	685:744	In order to improve understanding of the gelation mechanism in aqueous solution, this work presents a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels, similarly to an extremely coarse-grained molecular dynamics (MD) approach.
34936761	6	3	theme	processes	1262:1270	arg1	representation					1234:1247	a simplified representation	1221:1247	a simplified representation of atomistic processes	1221:1270	The model components are fully derived and parameterized using literature data and theoretical considerations based on a simplified representation of atomistic processes.
34936761	9	4	theme	literature	1691:1700	arg1	data					1702:1705	numerous literature data	1682:1705	numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering	1682:1867	The model is verified against numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering.
34936761	7	5	theme	classical	1428:1436	arg1	approaches					1447:1456	classical modeling approaches	1428:1456	classical modeling approaches such as MD	1428:1467	The presented model enables investigations of the higher-scale network formation during gelation on the micrometer and millisecond scale, which are beyond classical modeling approaches such as MD.
34936761	7	5	theme	classical	1428:1436	arg1	MD					1466:1467	MD	1466:1467	MD	1466:1467	The presented model enables investigations of the higher-scale network formation during gelation on the micrometer and millisecond scale, which are beyond classical modeling approaches such as MD.
34936761	3	6	theme	coarse-grained	698:711	arg1	MD					733:734	MD	733:734	MD	733:734	In order to improve understanding of the gelation mechanism in aqueous solution, this work presents a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels, similarly to an extremely coarse-grained molecular dynamics (MD) approach.
34936761	3	6	theme	coarse-grained	698:711	arg1	dynamics					723:730	extremely coarse-grained molecular dynamics	688:730	an extremely coarse-grained molecular dynamics (MD) approach	685:744	In order to improve understanding of the gelation mechanism in aqueous solution, this work presents a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels, similarly to an extremely coarse-grained molecular dynamics (MD) approach.
34936761	11	7	theme	motivated	2042:2050	arg1	design					2052:2057	physically motivated design	2031:2057	physically motivated design of alginate gels	2031:2074	Overall, the modeling approach paves the way to physically motivated design of alginate gels.
34936761	6	8	theme	simplified	1223:1232	arg1	representation					1234:1247	a simplified representation	1221:1247	a simplified representation of atomistic processes	1221:1270	The model components are fully derived and parameterized using literature data and theoretical considerations based on a simplified representation of atomistic processes.
34936761	3	9	theme	novel	566:570	arg1	approach					572:579	a novel approach	564:579	a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels	564:669	In order to improve understanding of the gelation mechanism in aqueous solution, this work presents a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels, similarly to an extremely coarse-grained molecular dynamics (MD) approach.
34936761	11	10	theme	gels	2071:2074	arg1	design					2052:2057	physically motivated design	2031:2057	physically motivated design of alginate gels	2031:2074	Overall, the modeling approach paves the way to physically motivated design of alginate gels.
34936761	9	11	theme	experimental	1722:1733	arg1	results					1735:1741	own experimental results	1718:1741	numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering	1682:1867	The model is verified against numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering.
34936761	7	12	theme	millisecond	1392:1402	arg1	scale					1404:1408	the micrometer and millisecond scale	1373:1408	scale	1404:1408	The presented model enables investigations of the higher-scale network formation during gelation on the micrometer and millisecond scale, which are beyond classical modeling approaches such as MD.
34936761	7	13	theme	higher-scale	1323:1334	arg1	formation					1344:1352	the higher-scale network formation	1319:1352	the higher-scale network formation	1319:1352	The presented model enables investigations of the higher-scale network formation during gelation on the micrometer and millisecond scale, which are beyond classical modeling approaches such as MD.
34936761	7	14	theme	micrometer	1377:1386	arg1	scale					1404:1408	the micrometer and millisecond scale	1373:1408	scale	1404:1408	The presented model enables investigations of the higher-scale network formation during gelation on the micrometer and millisecond scale, which are beyond classical modeling approaches such as MD.
34936761	5	15	theme	implicit	996:1003	arg1	model					1023:1027	an implicit probabilistic ion model	993:1027	an implicit probabilistic ion model to capture the effects of ion availability during ion-mediated gelation	993:1099	The model is based on Langevin dynamics and includes an implicit probabilistic ion model to capture the effects of ion availability during ion-mediated gelation.
34936761	9	16	theme	corresponding	1751:1763	arg1	hydrogels					1777:1785	the corresponding Ca-alginate hydrogels	1747:1785	the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering	1747:1867	The model is verified against numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering.
34936761	6	17	theme	theoretical	1185:1195	arg1	considerations					1197:1210	theoretical considerations	1185:1210	theoretical considerations	1185:1210	The model components are fully derived and parameterized using literature data and theoretical considerations based on a simplified representation of atomistic processes.
34936761	5	18	theme	ion	1019:1021	arg1	model					1023:1027	an implicit probabilistic ion model	993:1027	an implicit probabilistic ion model to capture the effects of ion availability during ion-mediated gelation	993:1099	The model is based on Langevin dynamics and includes an implicit probabilistic ion model to capture the effects of ion availability during ion-mediated gelation.
34936761	1	19	theme	great	115:119	arg1	interest					121:128	great interest	115:128	great interest in the material science community	115:162	The gelation of biopolymers is of great interest in the material science community and has gained increasing relevance in the past few decades, especially in the context of aerogels─lightweight open nanoporous materials.
34936761	5	20	theme	ion-mediated	1079:1090	arg1	gelation					1092:1099	ion-mediated gelation	1079:1099	ion-mediated gelation	1079:1099	The model is based on Langevin dynamics and includes an implicit probabilistic ion model to capture the effects of ion availability during ion-mediated gelation.
34936761	3	21	theme	element	603:609	arg1	method					611:616	the discrete element method	590:616	the discrete element method for the mesoscale for modeling gelation of hydrogels	590:669	In order to improve understanding of the gelation mechanism in aqueous solution, this work presents a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels, similarly to an extremely coarse-grained molecular dynamics (MD) approach.
34936761	4	22	with	interactions	834:845	arg1	diffusion					896:904	diffusion	896:904	diffusion in implicit water	896:922	For this, polymer chains are abstracted as dimer units connected by flexible bonds and interactions between units and with the environment, that is, diffusion in implicit water, are described.
34936761	4	22	with	interactions	834:845	arg1	environment					874:884	the environment	870:884	the environment	870:884	For this, polymer chains are abstracted as dimer units connected by flexible bonds and interactions between units and with the environment, that is, diffusion in implicit water, are described.
34936761	9	23	theme	nitrogen	1793:1800	arg1	porosimetry					1802:1812	nitrogen porosimetry	1793:1812	nitrogen porosimetry	1793:1812	The model is verified against numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering.
34936761	8	24	theme	calcium-mediated	1489:1504	arg1	gelation					1515:1522	calcium-mediated alginate gelation	1489:1522	calcium-mediated alginate gelation	1489:1522	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
34936761	8	24	theme	calcium-mediated	1489:1504	arg1	system					1481:1486	a model system	1473:1486	a model system	1473:1486	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
34936761	1	25	theme	material	137:144	arg1	community					154:162	the material science community	133:162	the material science community	133:162	The gelation of biopolymers is of great interest in the material science community and has gained increasing relevance in the past few decades, especially in the context of aerogels─lightweight open nanoporous materials.
34936761	4	26	with	bonds	824:828	arg1	diffusion					896:904	diffusion	896:904	diffusion in implicit water	896:922	For this, polymer chains are abstracted as dimer units connected by flexible bonds and interactions between units and with the environment, that is, diffusion in implicit water, are described.
34936761	4	26	with	bonds	824:828	arg1	environment					874:884	the environment	870:884	the environment	870:884	For this, polymer chains are abstracted as dimer units connected by flexible bonds and interactions between units and with the environment, that is, diffusion in implicit water, are described.
34936761	1	27	from	interest	121:128	arg1	community					154:162	the material science community	133:162	the material science community	133:162	The gelation of biopolymers is of great interest in the material science community and has gained increasing relevance in the past few decades, especially in the context of aerogels─lightweight open nanoporous materials.
34936761	4	28	theme	polymer	757:763	arg1	chains					765:770	polymer chains	757:770	polymer chains	757:770	For this, polymer chains are abstracted as dimer units connected by flexible bonds and interactions between units and with the environment, that is, diffusion in implicit water, are described.
34936761	2	29	theme	great	387:391	arg1	importance					393:402	great importance	387:402	great importance	387:402	Understanding the underlying gel structure and influence of process parameters is of great importance to predict material properties such as mechanical strength.
34936761	5	30	theme	availability	1059:1070	arg1	effects					1044:1050	the effects	1040:1050	the effects of ion availability during ion-mediated gelation	1040:1099	The model is based on Langevin dynamics and includes an implicit probabilistic ion model to capture the effects of ion availability during ion-mediated gelation.
34936761	7	31	theme	formation	1344:1352	arg1	investigations					1301:1314	investigations	1301:1314	investigations of the higher-scale network formation	1301:1352	The presented model enables investigations of the higher-scale network formation during gelation on the micrometer and millisecond scale, which are beyond classical modeling approaches such as MD.
34936761	2	32	theme	mechanical	443:452	arg1	strength					454:461	mechanical strength	443:461	mechanical strength	443:461	Understanding the underlying gel structure and influence of process parameters is of great importance to predict material properties such as mechanical strength.
34936761	0	33	theme	DEM-Based	0:8	arg1	Approach					10:17	DEM-Based Approach	0:17	DEM-Based Approach for the Modeling of Gelation	0:46	DEM-Based Approach for the Modeling of Gelation and Its Application to Alginate.
34936761	10	34	with	agreement	1951:1959	arg1	experiments					1970:1980	the experiments	1966:1980	the experiments	1966:1980	The model reproduces both bundle size and pore size distribution in a reasonable agreement with the experiments.
34936761	9	35	theme	neutron	1850:1856	arg1	scattering					1858:1867	small-angle neutron scattering	1838:1867	small-angle neutron scattering	1838:1867	The model is verified against numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering.
34936761	2	36	theme	material	415:422	arg1	properties					424:433	material properties	415:433	material properties such as mechanical strength	415:461	Understanding the underlying gel structure and influence of process parameters is of great importance to predict material properties such as mechanical strength.
34936761	2	36	theme	material	415:422	arg1	strength					454:461	mechanical strength	443:461	mechanical strength	443:461	Understanding the underlying gel structure and influence of process parameters is of great importance to predict material properties such as mechanical strength.
34936761	1	37	theme	aerogels─lightweight	254:273	arg1	materials					291:299	aerogels─lightweight open nanoporous materials	254:299	aerogels─lightweight open nanoporous materials	254:299	The gelation of biopolymers is of great interest in the material science community and has gained increasing relevance in the past few decades, especially in the context of aerogels─lightweight open nanoporous materials.
34936761	8	38	theme	concentration	1571:1583	arg1	influence					1554:1562	the influence	1550:1562	the influence of ion concentration, polymer composition, polymer concentration, and molecular weight	1550:1649	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
34936761	3	39	theme	modeling	640:647	arg1	gelation					649:656	modeling gelation	640:656	modeling gelation of hydrogels	640:669	In order to improve understanding of the gelation mechanism in aqueous solution, this work presents a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels, similarly to an extremely coarse-grained molecular dynamics (MD) approach.
34936761	1	40	theme	nanoporous	280:289	arg1	materials					291:299	aerogels─lightweight open nanoporous materials	254:299	aerogels─lightweight open nanoporous materials	254:299	The gelation of biopolymers is of great interest in the material science community and has gained increasing relevance in the past few decades, especially in the context of aerogels─lightweight open nanoporous materials.
34936761	8	41	theme	polymer	1586:1592	arg1	composition					1594:1604	polymer composition	1586:1604	polymer composition	1586:1604	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
34936761	0	42	theme	Gelation	39:46	arg1	Modeling					27:34	the Modeling	23:34	the Modeling of Gelation	23:46	DEM-Based Approach for the Modeling of Gelation and Its Application to Alginate.
34936761	7	43	theme	presented	1277:1285	arg1	model					1287:1291	The presented model	1273:1291	The presented model	1273:1291	The presented model enables investigations of the higher-scale network formation during gelation on the micrometer and millisecond scale, which are beyond classical modeling approaches such as MD.
34936761	2	44	theme	underlying	320:329	arg1	structure					335:343	the underlying gel structure	316:343	the underlying gel structure	316:343	Understanding the underlying gel structure and influence of process parameters is of great importance to predict material properties such as mechanical strength.
34936761	8	45	theme	concentration	1615:1627	arg1	influence					1554:1562	the influence	1550:1562	the influence of ion concentration, polymer composition, polymer concentration, and molecular weight	1550:1649	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
34936761	10	46	theme	pore	1912:1915	arg1	distribution					1922:1933	pore size distribution	1912:1933	pore size distribution	1912:1933	The model reproduces both bundle size and pore size distribution in a reasonable agreement with the experiments.
34936761	3	47	theme	mechanism	514:522	arg1	understanding					484:496	understanding	484:496	understanding of the gelation mechanism	484:522	In order to improve understanding of the gelation mechanism in aqueous solution, this work presents a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels, similarly to an extremely coarse-grained molecular dynamics (MD) approach.
34936761	1	48	theme	few	212:214	arg1	decades					216:222	the past few decades	203:222	the past few decades	203:222	The gelation of biopolymers is of great interest in the material science community and has gained increasing relevance in the past few decades, especially in the context of aerogels─lightweight open nanoporous materials.
34936761	5	49	theme	Langevin	962:969	arg1	dynamics					971:978	Langevin dynamics	962:978	Langevin dynamics	962:978	The model is based on Langevin dynamics and includes an implicit probabilistic ion model to capture the effects of ion availability during ion-mediated gelation.
34936761	8	50	theme	weight	1644:1649	arg1	influence					1554:1562	the influence	1550:1562	the influence of ion concentration, polymer composition, polymer concentration, and molecular weight	1550:1649	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
34936761	9	51	theme	numerous	1682:1689	arg1	data					1702:1705	numerous literature data	1682:1705	numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering	1682:1867	The model is verified against numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering.
34936761	6	52	theme	atomistic	1252:1260	arg1	processes					1262:1270	atomistic processes	1252:1270	atomistic processes	1252:1270	The model components are fully derived and parameterized using literature data and theoretical considerations based on a simplified representation of atomistic processes.
34936761	3	53	theme	aqueous	527:533	arg1	solution					535:542	aqueous solution	527:542	aqueous solution	527:542	In order to improve understanding of the gelation mechanism in aqueous solution, this work presents a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels, similarly to an extremely coarse-grained molecular dynamics (MD) approach.
34936761	1	54	theme	science	146:152	arg1	community					154:162	the material science community	133:162	the material science community	133:162	The gelation of biopolymers is of great interest in the material science community and has gained increasing relevance in the past few decades, especially in the context of aerogels─lightweight open nanoporous materials.
34936761	4	55	theme	flexible	815:822	arg1	bonds					824:828	flexible bonds	815:828	flexible bonds	815:828	For this, polymer chains are abstracted as dimer units connected by flexible bonds and interactions between units and with the environment, that is, diffusion in implicit water, are described.
34936761	7	56	theme	modeling	1438:1445	arg1	approaches					1447:1456	classical modeling approaches	1428:1456	classical modeling approaches such as MD	1428:1467	The presented model enables investigations of the higher-scale network formation during gelation on the micrometer and millisecond scale, which are beyond classical modeling approaches such as MD.
34936761	7	56	theme	modeling	1438:1445	arg1	MD					1466:1467	MD	1466:1467	MD	1466:1467	The presented model enables investigations of the higher-scale network formation during gelation on the micrometer and millisecond scale, which are beyond classical modeling approaches such as MD.
34936761	3	57	theme	molecular	713:721	arg1	MD					733:734	MD	733:734	MD	733:734	In order to improve understanding of the gelation mechanism in aqueous solution, this work presents a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels, similarly to an extremely coarse-grained molecular dynamics (MD) approach.
34936761	3	57	theme	molecular	713:721	arg1	dynamics					723:730	extremely coarse-grained molecular dynamics	688:730	an extremely coarse-grained molecular dynamics (MD) approach	685:744	In order to improve understanding of the gelation mechanism in aqueous solution, this work presents a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels, similarly to an extremely coarse-grained molecular dynamics (MD) approach.
34936761	11	58	theme	alginate	2062:2069	arg1	gels					2071:2074	alginate gels	2062:2074	alginate gels	2062:2074	Overall, the modeling approach paves the way to physically motivated design of alginate gels.
34936761	9	59	theme	own	1718:1720	arg1	results					1735:1741	own experimental results	1718:1741	numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering	1682:1867	The model is verified against numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering.
34936761	6	60	theme	model	1106:1110	arg1	components					1112:1121	The model components	1102:1121	The model components	1102:1121	The model components are fully derived and parameterized using literature data and theoretical considerations based on a simplified representation of atomistic processes.
34936761	4	61	from	diffusion	896:904	arg1	water					918:922	implicit water	909:922	implicit water	909:922	For this, polymer chains are abstracted as dimer units connected by flexible bonds and interactions between units and with the environment, that is, diffusion in implicit water, are described.
34936761	11	62	theme	modeling	1996:2003	arg1	approach					2005:2012	the modeling approach	1992:2012	the modeling approach	1992:2012	Overall, the modeling approach paves the way to physically motivated design of alginate gels.
34936761	1	63	theme	biopolymers	97:107	arg1	gelation					85:92	The gelation	81:92	The gelation of biopolymers	81:107	The gelation of biopolymers is of great interest in the material science community and has gained increasing relevance in the past few decades, especially in the context of aerogels─lightweight open nanoporous materials.
34936761	8	64	theme	model	1475:1479	arg1	gelation					1515:1522	calcium-mediated alginate gelation	1489:1522	calcium-mediated alginate gelation	1489:1522	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
34936761	8	64	theme	model	1475:1479	arg1	system					1481:1486	a model system	1473:1486	a model system	1473:1486	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
34936761	5	65	theme	probabilistic	1005:1017	arg1	model					1023:1027	an implicit probabilistic ion model	993:1027	an implicit probabilistic ion model to capture the effects of ion availability during ion-mediated gelation	993:1099	The model is based on Langevin dynamics and includes an implicit probabilistic ion model to capture the effects of ion availability during ion-mediated gelation.
34936761	9	66	theme	Ca-alginate	1765:1775	arg1	hydrogels					1777:1785	the corresponding Ca-alginate hydrogels	1747:1785	the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering	1747:1867	The model is verified against numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering.
34936761	3	67	theme	discrete	594:601	arg1	method					611:616	the discrete element method	590:616	the discrete element method for the mesoscale for modeling gelation of hydrogels	590:669	In order to improve understanding of the gelation mechanism in aqueous solution, this work presents a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels, similarly to an extremely coarse-grained molecular dynamics (MD) approach.
34936761	8	68	theme	alginate	1506:1513	arg1	gelation					1515:1522	calcium-mediated alginate gelation	1489:1522	calcium-mediated alginate gelation	1489:1522	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
34936761	8	68	theme	alginate	1506:1513	arg1	system					1481:1486	a model system	1473:1486	a model system	1473:1486	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
34936761	6	69	theme	literature	1165:1174	arg1	data					1176:1179	literature data	1165:1179	literature data	1165:1179	The model components are fully derived and parameterized using literature data and theoretical considerations based on a simplified representation of atomistic processes.
34936761	9	70	theme	NMR	1815:1817	arg1	cryoporometry					1819:1831	NMR cryoporometry	1815:1831	NMR cryoporometry	1815:1831	The model is verified against numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering.
34936761	4	71	theme	implicit	909:916	arg1	water					918:922	implicit water	909:922	implicit water	909:922	For this, polymer chains are abstracted as dimer units connected by flexible bonds and interactions between units and with the environment, that is, diffusion in implicit water, are described.
34936761	5	72	theme	ion	1055:1057	arg1	availability					1059:1070	ion availability	1055:1070	ion availability	1055:1070	The model is based on Langevin dynamics and includes an implicit probabilistic ion model to capture the effects of ion availability during ion-mediated gelation.
34936761	7	73	theme	network	1336:1342	arg1	formation					1344:1352	the higher-scale network formation	1319:1352	the higher-scale network formation	1319:1352	The presented model enables investigations of the higher-scale network formation during gelation on the micrometer and millisecond scale, which are beyond classical modeling approaches such as MD.
34936761	9	74	theme	small-angle	1838:1848	arg1	scattering					1858:1867	small-angle neutron scattering	1838:1867	small-angle neutron scattering	1838:1867	The model is verified against numerous literature data as well as own experimental results for the corresponding Ca-alginate hydrogels using nitrogen porosimetry, NMR cryoporometry, and small-angle neutron scattering.
34936761	8	75	theme	ion	1567:1569	arg1	concentration					1571:1583	ion concentration	1567:1583	ion concentration	1567:1583	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
34936761	2	76	theme	parameters	370:379	arg1	influence					349:357	influence	349:357	influence of process parameters	349:379	Understanding the underlying gel structure and influence of process parameters is of great importance to predict material properties such as mechanical strength.
34936761	2	76	theme	parameters	370:379	arg1	structure					335:343	the underlying gel structure	316:343	the underlying gel structure	316:343	Understanding the underlying gel structure and influence of process parameters is of great importance to predict material properties such as mechanical strength.
34936761	2	77	theme	process	362:368	arg1	parameters					370:379	process parameters	362:379	process parameters	362:379	Understanding the underlying gel structure and influence of process parameters is of great importance to predict material properties such as mechanical strength.
34936761	1	78	theme	open	275:278	arg1	materials					291:299	aerogels─lightweight open nanoporous materials	254:299	aerogels─lightweight open nanoporous materials	254:299	The gelation of biopolymers is of great interest in the material science community and has gained increasing relevance in the past few decades, especially in the context of aerogels─lightweight open nanoporous materials.
34936761	8	79	theme	composition	1594:1604	arg1	influence					1554:1562	the influence	1550:1562	the influence of ion concentration, polymer composition, polymer concentration, and molecular weight	1550:1649	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
34936761	10	80	theme	bundle	1896:1901	arg1	size					1903:1906	bundle size	1896:1906	bundle size	1896:1906	The model reproduces both bundle size and pore size distribution in a reasonable agreement with the experiments.
34936761	4	81	theme	dimer	790:794	arg1	units					796:800	dimer units	790:800	dimer units connected by flexible bonds and interactions between units and with the environment, that is, diffusion in implicit water,	790:923	For this, polymer chains are abstracted as dimer units connected by flexible bonds and interactions between units and with the environment, that is, diffusion in implicit water, are described.
34936761	1	82	theme	materials	291:299	arg1	context					243:249	the context	239:249	the context of aerogels─lightweight open nanoporous materials	239:299	The gelation of biopolymers is of great interest in the material science community and has gained increasing relevance in the past few decades, especially in the context of aerogels─lightweight open nanoporous materials.
34936761	8	83	theme	polymer	1607:1613	arg1	concentration					1615:1627	polymer concentration	1607:1627	polymer concentration	1607:1627	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
34936761	3	84	theme	hydrogels	661:669	arg1	gelation					649:656	modeling gelation	640:656	modeling gelation of hydrogels	640:669	In order to improve understanding of the gelation mechanism in aqueous solution, this work presents a novel approach based on the discrete element method for the mesoscale for modeling gelation of hydrogels, similarly to an extremely coarse-grained molecular dynamics (MD) approach.
34936761	2	85	theme	gel	331:333	arg1	structure					335:343	the underlying gel structure	316:343	the underlying gel structure	316:343	Understanding the underlying gel structure and influence of process parameters is of great importance to predict material properties such as mechanical strength.
34936761	10	86	theme	size	1917:1920	arg1	distribution					1922:1933	pore size distribution	1912:1933	pore size distribution	1912:1933	The model reproduces both bundle size and pore size distribution in a reasonable agreement with the experiments.
34936761	1	87	theme	past	207:210	arg1	decades					216:222	the past few decades	203:222	the past few decades	203:222	The gelation of biopolymers is of great interest in the material science community and has gained increasing relevance in the past few decades, especially in the context of aerogels─lightweight open nanoporous materials.
34936761	8	88	theme	molecular	1634:1642	arg1	weight					1644:1649	molecular weight	1634:1649	molecular weight	1634:1649	As a model system, calcium-mediated alginate gelation is investigated including the influence of ion concentration, polymer composition, polymer concentration, and molecular weight.
32516910	7	0	theme	sialylated	1167:1176	arg1	FA2BG2S2					1208:1215	FA2BG2S2	1208:1215	FA2BG2S2	1208:1215	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	7	0	theme	sialylated	1167:1176	arg1	glycan					1200:1205	sialylated bisecting biantennary glycan	1167:1205	sialylated bisecting biantennary glycan (FA2BG2S2)	1167:1216	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	7	0	theme	sialylated	1167:1176	arg1	fucosylated					1154:1164	Only serum core fucosylated	1138:1164	Only serum core fucosylated	1138:1164	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	8	1	theme	APSCT	1549:1553	arg1	effect					1539:1544	the effect	1535:1544	the effect of APSCT on local immunity	1535:1571	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	5	2	theme	different	881:889	arg1	stages					891:896	four different stages	876:896	four different stages of transplantation (day -3/-7, 0, +7, +14)	876:939	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	8	3	from	changes	1364:1370	arg1	profile					1404:1410	the serum IgA total N-glycan profile	1375:1410	the serum IgA total N-glycan profile	1375:1410	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	0	4	theme	Possible	71:78	arg1	Biomarker					80:88	a Possible Biomarker	69:88	a Possible Biomarker in Oral Mucositis	69:106	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a Is a Possible Biomarker in Oral Mucositis.
32516910	0	4	theme	Possible	71:78	arg1	Alteration					16:25	N-Glycosylation Alteration	0:25	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a	0:64	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a Is a Possible Biomarker in Oral Mucositis.
32516910	3	5	from	important	440:448	arg1	inflammation					498:509	inflammation	498:509	inflammation	498:509	Altered salivary sialoglycoprotein carbohydrates are important in the pathologies in the oral cavity including inflammation, infection and neoplasia.
32516910	3	5	from	important	440:448	arg1	neoplasia					526:534	neoplasia	526:534	neoplasia	526:534	Altered salivary sialoglycoprotein carbohydrates are important in the pathologies in the oral cavity including inflammation, infection and neoplasia.
32516910	3	5	from	important	440:448	arg1	pathologies					457:467	the pathologies	453:467	the pathologies in the oral cavity including inflammation, infection and neoplasia	453:534	Altered salivary sialoglycoprotein carbohydrates are important in the pathologies in the oral cavity including inflammation, infection and neoplasia.
32516910	3	5	from	important	440:448	arg1	infection					512:520	infection	512:520	infection	512:520	Altered salivary sialoglycoprotein carbohydrates are important in the pathologies in the oral cavity including inflammation, infection and neoplasia.
32516910	5	6	theme	capillary	694:702	arg1	electrophoresis					704:718	capillary electrophoresis	694:718	capillary electrophoresis	694:718	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	2	7	theme	first	364:368	arg1	line					370:373	the first line	360:373	the first line of defense	360:384	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	4	8	theme	IgA	602:604	arg1	glycosylation					606:618	the salivary and serum IgA glycosylation	579:618	the salivary and serum IgA glycosylation	579:618	Therefore, we assessed whether changes in the salivary and serum IgA glycosylation correlated with development and severity of oral mucositis.
32516910	0	9	theme	Oral	93:96	arg1	Mucositis					98:106	Oral Mucositis	93:106	Oral Mucositis	93:106	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a Is a Possible Biomarker in Oral Mucositis.
32516910	8	10	theme	N-glycan	1395:1402	arg1	profile					1404:1410	the serum IgA total N-glycan profile	1375:1410	the serum IgA total N-glycan profile	1375:1410	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	8	11	from	effect	1539:1544	arg1	immunity					1564:1571	local immunity	1558:1571	local immunity	1558:1571	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	2	12	from	pillar	332:337	arg1	line					370:373	the first line	360:373	the first line of defense	360:384	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	7	13	theme	transplantation	1275:1289	arg1	stages					1265:1270	any two stages	1257:1270	any two stages of transplantation	1257:1289	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	8	14	theme	IgA	1513:1515	arg1	N-glycan					1517:1524	salivary IgA N-glycan	1504:1524	salivary IgA N-glycan	1504:1524	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	7	15	theme	core	1149:1152	arg1	glycan					1200:1205	sialylated bisecting biantennary glycan	1167:1205	sialylated bisecting biantennary glycan (FA2BG2S2)	1167:1216	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	7	15	theme	core	1149:1152	arg1	fucosylated					1154:1164	Only serum core fucosylated	1138:1164	Only serum core fucosylated	1138:1164	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	2	16	theme	local	342:346	arg1	immunity					348:355	local immunity	342:355	local immunity	342:355	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	8	17	theme	salivary	1504:1511	arg1	N-glycan					1517:1524	salivary IgA N-glycan	1504:1524	salivary IgA N-glycan	1504:1524	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	3	18	gly	sialoglycoprotein	404:420	arg1	sialoglycoprotein					404:420	Altered salivary sialoglycoprotein carbohydrates	387:434	Altered salivary sialoglycoprotein carbohydrates	387:434	Altered salivary sialoglycoprotein carbohydrates are important in the pathologies in the oral cavity including inflammation, infection and neoplasia.
32516910	1	19	theme	cytostatic	164:173	arg1	treatment					175:183	high-dose cytostatic treatment	154:183	high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation	154:255	BACKGROUND Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation increases mortality.
32516910	7	20	theme	serum	1143:1147	arg1	glycan					1200:1205	sialylated bisecting biantennary glycan	1167:1205	sialylated bisecting biantennary glycan (FA2BG2S2)	1167:1216	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	7	20	theme	serum	1143:1147	arg1	fucosylated					1154:1164	Only serum core fucosylated	1138:1164	Only serum core fucosylated	1138:1164	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	5	21	theme	peripheral	828:837	arg1	transplantation					849:863	autologous peripheral stem-cell transplantation	817:863	autologous peripheral stem-cell transplantation (APSCT)	817:871	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	5	21	theme	peripheral	828:837	arg1	APSCT					866:870	APSCT	866:870	APSCT	866:870	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	4	22	theme	mucositis	669:677	arg1	severity					652:659	severity	652:659	severity	652:659	Therefore, we assessed whether changes in the salivary and serum IgA glycosylation correlated with development and severity of oral mucositis.
32516910	4	22	theme	mucositis	669:677	arg1	development					636:646	development	636:646	development	636:646	Therefore, we assessed whether changes in the salivary and serum IgA glycosylation correlated with development and severity of oral mucositis.
32516910	3	23	theme	sialoglycoprotein	404:420	arg1	carbohydrates					422:434	Altered salivary sialoglycoprotein carbohydrates	387:434	Altered salivary sialoglycoprotein carbohydrates	387:434	Altered salivary sialoglycoprotein carbohydrates are important in the pathologies in the oral cavity including inflammation, infection and neoplasia.
32516910	6	24	theme	significant	1064:1074	arg1	changes					1076:1082	significant changes	1064:1082	significant changes	1064:1082	RESULTS Fourteen out of the 31 structures identified in serum and 6 out of 38 in saliva showed significant changes upon transplantation compared with the control group.
32516910	3	25	theme	salivary	395:402	arg1	carbohydrates					422:434	Altered salivary sialoglycoprotein carbohydrates	387:434	Altered salivary sialoglycoprotein carbohydrates	387:434	Altered salivary sialoglycoprotein carbohydrates are important in the pathologies in the oral cavity including inflammation, infection and neoplasia.
32516910	5	26	theme	autologous	817:826	arg1	transplantation					849:863	autologous peripheral stem-cell transplantation	817:863	autologous peripheral stem-cell transplantation (APSCT)	817:871	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	5	26	theme	autologous	817:826	arg1	APSCT					866:870	APSCT	866:870	APSCT	866:870	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	7	27	theme	significant	1225:1235	arg1	differences					1237:1247	significant differences	1225:1247	significant differences between any two stages of transplantation	1225:1289	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	0	28	theme	N-Glycosylation	0:14	arg1	Biomarker					80:88	a Possible Biomarker	69:88	a Possible Biomarker in Oral Mucositis	69:106	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a Is a Possible Biomarker in Oral Mucositis.
32516910	0	28	theme	N-Glycosylation	0:14	arg1	Alteration					16:25	N-Glycosylation Alteration	0:25	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a	0:64	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a Is a Possible Biomarker in Oral Mucositis.
32516910	4	29	theme	salivary	583:590	arg1	glycosylation					606:618	the salivary and serum IgA glycosylation	579:618	the salivary and serum IgA glycosylation	579:618	Therefore, we assessed whether changes in the salivary and serum IgA glycosylation correlated with development and severity of oral mucositis.
32516910	5	30	theme	healthy	951:957	arg1	controls					959:966	10 healthy controls	948:966	10 healthy controls	948:966	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	0	31	theme	Serum	30:34	arg1	Biomarker					80:88	a Possible Biomarker	69:88	a Possible Biomarker in Oral Mucositis	69:106	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a Is a Possible Biomarker in Oral Mucositis.
32516910	0	31	theme	Serum	30:34	arg1	Alteration					16:25	N-Glycosylation Alteration	0:25	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a	0:64	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a Is a Possible Biomarker in Oral Mucositis.
32516910	7	32	gly	sialylated	1167:1176	arg1	FA2BG2S2					1208:1215	FA2BG2S2	1208:1215	FA2BG2S2	1208:1215	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	7	32	gly	sialylated	1167:1176	arg1	glycan					1200:1205	sialylated bisecting biantennary glycan	1167:1205	sialylated bisecting biantennary glycan (FA2BG2S2)	1167:1216	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	7	32	gly	sialylated	1167:1176	arg1	fucosylated					1154:1164	Only serum core fucosylated	1138:1164	Only serum core fucosylated	1138:1164	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	6	33	from	38	1044:1045	arg1	saliva					1050:1055	saliva	1050:1055	saliva	1050:1055	RESULTS Fourteen out of the 31 structures identified in serum and 6 out of 38 in saliva showed significant changes upon transplantation compared with the control group.
32516910	2	34	theme	basic	326:330	arg1	pillar					332:337	a basic pillar	324:337	a basic pillar of local immunity in the first line of defense	324:384	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	2	34	theme	basic	326:330	arg1	A					312:312	Salivary secretory immunoglobulin A	278:312	Salivary secretory immunoglobulin A (sIgA)	278:319	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	8	35	theme	serum	1379:1383	arg1	profile					1404:1410	the serum IgA total N-glycan profile	1375:1410	the serum IgA total N-glycan profile	1375:1410	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	1	36	theme	autologous	205:214	arg1	transplantation					241:255	autologous and allogeneic stem-cell transplantation	205:255	transplantation	241:255	BACKGROUND Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation increases mortality.
32516910	3	37	theme	Altered	387:393	arg1	carbohydrates					422:434	Altered salivary sialoglycoprotein carbohydrates	387:434	Altered salivary sialoglycoprotein carbohydrates	387:434	Altered salivary sialoglycoprotein carbohydrates are important in the pathologies in the oral cavity including inflammation, infection and neoplasia.
32516910	4	38	theme	serum	596:600	arg1	IgA					602:604	serum IgA	596:604	serum IgA	596:604	Therefore, we assessed whether changes in the salivary and serum IgA glycosylation correlated with development and severity of oral mucositis.
32516910	5	39	theme	salivary	755:762	arg1	N-glycans					774:782	salivary IgA total N-glycans	755:782	salivary IgA total N-glycans	755:782	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	0	40	from	Biomarker	80:88	arg1	Mucositis					98:106	Oral Mucositis	93:106	Oral Mucositis	93:106	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a Is a Possible Biomarker in Oral Mucositis.
32516910	1	41	theme	high-dose	154:162	arg1	treatment					175:183	high-dose cytostatic treatment	154:183	high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation	154:255	BACKGROUND Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation increases mortality.
32516910	4	42	theme	oral	664:667	arg1	mucositis					669:677	oral mucositis	664:677	oral mucositis	664:677	Therefore, we assessed whether changes in the salivary and serum IgA glycosylation correlated with development and severity of oral mucositis.
32516910	0	43	theme	Salivary	40:47	arg1	a					64:64	Salivary Immunoglobulin a	40:64	Salivary Immunoglobulin a	40:64	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a Is a Possible Biomarker in Oral Mucositis.
32516910	5	44	theme	IgA	764:766	arg1	N-glycans					774:782	salivary IgA total N-glycans	755:782	salivary IgA total N-glycans	755:782	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	3	45	theme	oral	476:479	arg1	cavity					481:486	the oral cavity	472:486	the oral cavity	472:486	Altered salivary sialoglycoprotein carbohydrates are important in the pathologies in the oral cavity including inflammation, infection and neoplasia.
32516910	5	46	theme	total	768:772	arg1	N-glycans					774:782	salivary IgA total N-glycans	755:782	salivary IgA total N-glycans	755:782	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	1	47	theme	allogeneic	220:229	arg1	transplantation					241:255	autologous and allogeneic stem-cell transplantation	205:255	transplantation	241:255	BACKGROUND Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation increases mortality.
32516910	4	48	from	changes	568:574	arg1	glycosylation					606:618	the salivary and serum IgA glycosylation	579:618	the salivary and serum IgA glycosylation	579:618	Therefore, we assessed whether changes in the salivary and serum IgA glycosylation correlated with development and severity of oral mucositis.
32516910	8	49	theme	local	1558:1562	arg1	immunity					1564:1571	local immunity	1558:1571	local immunity	1558:1571	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	5	50	theme	stem-cell	839:847	arg1	transplantation					849:863	autologous peripheral stem-cell transplantation	817:863	autologous peripheral stem-cell transplantation (APSCT)	817:871	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	5	50	theme	stem-cell	839:847	arg1	APSCT					866:870	APSCT	866:870	APSCT	866:870	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	7	51	dep	=	1317:1317	arg1	day					1292:1294	day -3/-7	1292:1300	day -3/-7	1292:1300	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	7	51	dep	=	1317:1317	arg1	day					1306:1308	day +14	1306:1312	day +14	1306:1312	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	1	52	theme	stem-cell	231:239	arg1	transplantation					241:255	autologous and allogeneic stem-cell transplantation	205:255	transplantation	241:255	BACKGROUND Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation increases mortality.
32516910	0	53	theme	a	64:64	arg1	Biomarker					80:88	a Possible Biomarker	69:88	a Possible Biomarker in Oral Mucositis	69:106	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a Is a Possible Biomarker in Oral Mucositis.
32516910	0	53	theme	a	64:64	arg1	Alteration					16:25	N-Glycosylation Alteration	0:25	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a	0:64	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a Is a Possible Biomarker in Oral Mucositis.
32516910	8	54	theme	N-glycan	1517:1524	arg1	analysis					1492:1499	analysis	1492:1499	analysis of salivary IgA N-glycan	1492:1524	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	5	55	theme	comparative	721:731	arg1	analysis					733:740	comparative analysis	721:740	comparative analysis of serum	721:749	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	8	56	theme	disease-specific	1429:1444	arg1	biomarker					1446:1454	a disease-specific biomarker	1427:1454	a disease-specific biomarker in patients undergoing APSCT	1427:1483	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	8	56	theme	disease-specific	1429:1444	arg1	changes					1364:1370	changes	1364:1370	changes in the serum IgA total N-glycan profile	1364:1410	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	8	57	theme	total	1389:1393	arg1	profile					1404:1410	the serum IgA total N-glycan profile	1375:1410	the serum IgA total N-glycan profile	1375:1410	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	1	58	theme	BACKGROUND	109:118	arg1	mucositis					137:145	BACKGROUND Oral and enteral mucositis	109:145	BACKGROUND Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation	109:255	BACKGROUND Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation increases mortality.
32516910	0	59	theme	Immunoglobulin	49:62	arg1	a					64:64	Salivary Immunoglobulin a	40:64	Salivary Immunoglobulin a	40:64	N-Glycosylation Alteration of Serum and Salivary Immunoglobulin a Is a Possible Biomarker in Oral Mucositis.
32516910	8	60	theme	IgA	1385:1387	arg1	profile					1404:1410	the serum IgA total N-glycan profile	1375:1410	the serum IgA total N-glycan profile	1375:1410	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	8	61	dep	CONCLUSION	1328:1337	arg1	suggest					1351:1357	suggest	1351:1357	suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity	1351:1571	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	1	62	theme	Oral	120:123	arg1	mucositis					137:145	BACKGROUND Oral and enteral mucositis	109:145	BACKGROUND Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation	109:255	BACKGROUND Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation increases mortality.
32516910	5	63	with	patients	803:810	arg1	transplantation					849:863	autologous peripheral stem-cell transplantation	817:863	autologous peripheral stem-cell transplantation (APSCT)	817:871	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	5	63	with	patients	803:810	arg1	APSCT					866:870	APSCT	866:870	APSCT	866:870	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	6	64	dep	RESULTS	969:975	arg1	showed					1057:1062	showed	1057:1062	showed significant changes upon transplantation compared with the control group	1057:1135	RESULTS Fourteen out of the 31 structures identified in serum and 6 out of 38 in saliva showed significant changes upon transplantation compared with the control group.
32516910	2	65	theme	immunity	348:355	arg1	pillar					332:337	a basic pillar	324:337	a basic pillar of local immunity in the first line of defense	324:384	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	2	65	theme	immunity	348:355	arg1	A					312:312	Salivary secretory immunoglobulin A	278:312	Salivary secretory immunoglobulin A (sIgA)	278:319	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	5	66	theme	serum	745:749	arg1	N-glycans					774:782	salivary IgA total N-glycans	755:782	salivary IgA total N-glycans	755:782	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	5	66	theme	serum	745:749	arg1	electrophoresis					704:718	capillary electrophoresis	694:718	capillary electrophoresis	694:718	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	5	66	theme	serum	745:749	arg1	analysis					733:740	comparative analysis	721:740	comparative analysis of serum	721:749	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	2	67	theme	immunoglobulin	297:310	arg1	pillar					332:337	a basic pillar	324:337	a basic pillar of local immunity in the first line of defense	324:384	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	2	67	theme	immunoglobulin	297:310	arg1	sIgA					315:318	sIgA	315:318	sIgA	315:318	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	2	67	theme	immunoglobulin	297:310	arg1	A					312:312	Salivary secretory immunoglobulin A	278:312	Salivary secretory immunoglobulin A (sIgA)	278:319	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	1	68	theme	enteral	129:135	arg1	mucositis					137:145	BACKGROUND Oral and enteral mucositis	109:145	BACKGROUND Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation	109:255	BACKGROUND Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation increases mortality.
32516910	6	69	theme	control	1123:1129	arg1	group					1131:1135	the control group	1119:1135	the control group	1119:1135	RESULTS Fourteen out of the 31 structures identified in serum and 6 out of 38 in saliva showed significant changes upon transplantation compared with the control group.
32516910	8	70	from	biomarker	1446:1454	arg1	patients					1459:1466	patients	1459:1466	patients undergoing APSCT	1459:1483	CONCLUSION Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.
32516910	5	71	theme	transplantation	901:915	arg1	stages					891:896	four different stages	876:896	four different stages of transplantation (day -3/-7, 0, +7, +14)	876:939	METHODS Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day -3/-7, 0, +7, +14) and in 10 healthy controls.
32516910	2	72	theme	secretory	287:295	arg1	pillar					332:337	a basic pillar	324:337	a basic pillar of local immunity in the first line of defense	324:384	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	2	72	theme	secretory	287:295	arg1	sIgA					315:318	sIgA	315:318	sIgA	315:318	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	2	72	theme	secretory	287:295	arg1	A					312:312	Salivary secretory immunoglobulin A	278:312	Salivary secretory immunoglobulin A (sIgA)	278:319	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	3	73	from	pathologies	457:467	arg1	cavity					481:486	the oral cavity	472:486	the oral cavity	472:486	Altered salivary sialoglycoprotein carbohydrates are important in the pathologies in the oral cavity including inflammation, infection and neoplasia.
32516910	3	73	from	pathologies	457:467	arg1	important					440:448	important	440:448	important	440:448	Altered salivary sialoglycoprotein carbohydrates are important in the pathologies in the oral cavity including inflammation, infection and neoplasia.
32516910	2	74	theme	defense	378:384	arg1	line					370:373	the first line	360:373	the first line of defense	360:384	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	2	75	theme	Salivary	278:285	arg1	pillar					332:337	a basic pillar	324:337	a basic pillar of local immunity in the first line of defense	324:384	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	2	75	theme	Salivary	278:285	arg1	sIgA					315:318	sIgA	315:318	sIgA	315:318	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	2	75	theme	Salivary	278:285	arg1	A					312:312	Salivary secretory immunoglobulin A	278:312	Salivary secretory immunoglobulin A (sIgA)	278:319	Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense.
32516910	7	76	theme	bisecting	1178:1186	arg1	FA2BG2S2					1208:1215	FA2BG2S2	1208:1215	FA2BG2S2	1208:1215	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	7	76	theme	bisecting	1178:1186	arg1	glycan					1200:1205	sialylated bisecting biantennary glycan	1167:1205	sialylated bisecting biantennary glycan (FA2BG2S2)	1167:1216	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	7	76	theme	bisecting	1178:1186	arg1	fucosylated					1154:1164	Only serum core fucosylated	1138:1164	Only serum core fucosylated	1138:1164	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	7	77	theme	biantennary	1188:1198	arg1	FA2BG2S2					1208:1215	FA2BG2S2	1208:1215	FA2BG2S2	1208:1215	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	7	77	theme	biantennary	1188:1198	arg1	glycan					1200:1205	sialylated bisecting biantennary glycan	1167:1205	sialylated bisecting biantennary glycan (FA2BG2S2)	1167:1216	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32516910	7	77	theme	biantennary	1188:1198	arg1	fucosylated					1154:1164	Only serum core fucosylated	1138:1164	Only serum core fucosylated	1138:1164	Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day -3/-7 and day +14; p = 0.0279).
32720737	8	0	theme	A	1391:1391	arg1	signal					1358:1363	the signal	1354:1363	the signal of diphosphorylated lipid A	1354:1391	We also demonstrated that the signal of diphosphorylated lipid A can be enhanced with the use of additives in the matrix.
32720737	5	1	theme	lipid	879:883	arg1	species					887:893	the entire lipid A species	868:893	the entire lipid A species present in a sample	868:913	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	9	2	dep	conditions	1484:1493	arg1	obtain					1498:1503	obtain	1498:1503	to obtain a clear signal of both lipids A without prompt fragmentation	1495:1564	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	1	3	theme	key	246:248	arg1	factor					250:255	a key factor	244:255	a key factor of bacterial virulence	244:278	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	9	4	theme	trifluoroacetic	1597:1611	arg1	acid					1613:1616	10mM trifluoroacetic acid	1592:1616	10mM trifluoroacetic acid (TFA)	1592:1622	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	9	4	theme	trifluoroacetic	1597:1611	arg1	TFA					1619:1621	TFA	1619:1621	TFA	1619:1621	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	2	5	from	implications	441:452	arg1	process					472:478	the infectious process	457:478	the infectious process	457:478	As lipid A's structure differs among bacterial species and varies between strains of the same species, knowing its modifications is essential to understand its implications in the infectious process.
32720737	6	6	theme	ketodeoxyoctonic	1099:1114	arg1	KDO					1122:1124	KDO	1122:1124	KDO	1122:1124	The first commercial one contains single phosphorylation group, and the second contains two phosphorylation and two ketodeoxyoctonic acid (KDO) groups.
32720737	6	6	theme	ketodeoxyoctonic	1099:1114	arg1	acid					1116:1119	ketodeoxyoctonic acid	1099:1119	ketodeoxyoctonic acid (KDO)	1099:1125	The first commercial one contains single phosphorylation group, and the second contains two phosphorylation and two ketodeoxyoctonic acid (KDO) groups.
32720737	5	7	theme	A	885:885	arg1	species					887:893	the entire lipid A species	868:893	the entire lipid A species present in a sample	868:913	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	8	8	theme	additives	1425:1433	arg1	use					1418:1420	the use	1414:1420	the use of additives in the matrix	1414:1447	We also demonstrated that the signal of diphosphorylated lipid A can be enhanced with the use of additives in the matrix.
32720737	8	9	from	use	1418:1420	arg1	matrix					1442:1447	the matrix	1438:1447	the matrix	1438:1447	We also demonstrated that the signal of diphosphorylated lipid A can be enhanced with the use of additives in the matrix.
32720737	0	10	from	Effect	0:5	arg1	lipids					77:82	phosphorylated and ketodeoxyoctonic acid lipids	36:82	phosphorylated and ketodeoxyoctonic acid lipids	36:82	Effect of matrices and additives on phosphorylated and ketodeoxyoctonic acid lipids A analysis by matrix-assisted laser desorption ionization-mass spectrometry.
32720737	3	11	theme	matrix-assisted	506:520	arg1	spectrometry					555:566	matrix-assisted laser desorption ionization-mass spectrometry	506:566	matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS)	506:577	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	11	theme	matrix-assisted	506:520	arg1	fast					611:614	fast	611:614	fast	611:614	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	11	theme	matrix-assisted	506:520	arg1	method					596:601	a well-suited method	582:601	a well-suited method that is fast and efficient	582:628	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	11	theme	matrix-assisted	506:520	arg1	MALDI-MS					569:576	MALDI-MS	569:576	MALDI-MS	569:576	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	2	12	theme	lipid	284:288	arg1	structure					294:302	lipid A's structure	284:302	lipid A's structure	284:302	As lipid A's structure differs among bacterial species and varies between strains of the same species, knowing its modifications is essential to understand its implications in the infectious process.
32720737	5	13	from	matrices	929:936	arg1	lipids					973:978	two commercial lipids	958:978	two commercial lipids A	958:980	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	7	14	theme	KDO	1158:1160	arg1	groups					1162:1167	KDO groups	1158:1167	KDO groups	1158:1167	The lipid A containing KDO groups was essentially detected by the 3-hydroxypicolinic acid (3-HPA) matrix, whereas the monophosphorylated lipid A could be detected by 13 matrices out of the 16.
32720737	1	15	theme	bacterial	260:268	arg1	virulence					270:278	bacterial virulence	260:278	bacterial virulence	260:278	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	0	16	theme	laser	114:118	arg1	spectrometry					147:158	matrix-assisted laser desorption ionization-mass spectrometry	98:158	matrix-assisted laser desorption ionization-mass spectrometry	98:158	Effect of matrices and additives on phosphorylated and ketodeoxyoctonic acid lipids A analysis by matrix-assisted laser desorption ionization-mass spectrometry.
32720737	7	17	theme	16	1324:1325	arg1	matrices					1304:1311	13 matrices	1301:1311	13 matrices out of the 16	1301:1325	The lipid A containing KDO groups was essentially detected by the 3-hydroxypicolinic acid (3-HPA) matrix, whereas the monophosphorylated lipid A could be detected by 13 matrices out of the 16.
32720737	7	18	theme	monophosphorylated	1253:1270	arg1	A					1278:1278	the monophosphorylated lipid A	1249:1278	the monophosphorylated lipid A	1249:1278	The lipid A containing KDO groups was essentially detected by the 3-hydroxypicolinic acid (3-HPA) matrix, whereas the monophosphorylated lipid A could be detected by 13 matrices out of the 16.
32720737	3	19	theme	desorption	528:537	arg1	spectrometry					555:566	matrix-assisted laser desorption ionization-mass spectrometry	506:566	matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS)	506:577	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	19	theme	desorption	528:537	arg1	fast					611:614	fast	611:614	fast	611:614	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	19	theme	desorption	528:537	arg1	method					596:601	a well-suited method	582:601	a well-suited method that is fast and efficient	582:628	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	19	theme	desorption	528:537	arg1	MALDI-MS					569:576	MALDI-MS	569:576	MALDI-MS	569:576	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	5	20	dep	lipids	973:978	arg1	A					980:980	A	980:980	two commercial lipids A	958:980	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	1	21	theme	major	174:178	arg1	A					167:167	Lipid A	161:167	Lipid A	161:167	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	1	21	theme	major	174:178	arg1	compound					180:187	a major compound	172:187	a major compound of the outer membrane of gram-negative bacteria	172:235	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	0	22	theme	matrix-assisted	98:112	arg1	spectrometry					147:158	matrix-assisted laser desorption ionization-mass spectrometry	98:158	matrix-assisted laser desorption ionization-mass spectrometry	98:158	Effect of matrices and additives on phosphorylated and ketodeoxyoctonic acid lipids A analysis by matrix-assisted laser desorption ionization-mass spectrometry.
32720737	4	23	theme	biological	816:825	arg1	samples					827:833	biological samples	816:833	biological samples	816:833	However, there are limitations with the matrix and additives used, such as the suppression of signal or prompt fragmentations that could give a false overview of lipid A composition in biological samples.
32720737	3	24	theme	ionization-mass	539:553	arg1	spectrometry					555:566	matrix-assisted laser desorption ionization-mass spectrometry	506:566	matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS)	506:577	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	24	theme	ionization-mass	539:553	arg1	fast					611:614	fast	611:614	fast	611:614	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	24	theme	ionization-mass	539:553	arg1	method					596:601	a well-suited method	582:601	a well-suited method that is fast and efficient	582:628	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	24	theme	ionization-mass	539:553	arg1	MALDI-MS					569:576	MALDI-MS	569:576	MALDI-MS	569:576	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	5	25	from	additives	945:953	arg1	lipids					973:978	two commercial lipids	958:978	two commercial lipids A	958:980	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	5	26	theme	comprehensive	842:854	arg1	analysis					856:863	a comprehensive analysis	840:863	a comprehensive analysis of the entire lipid A species present in a sample	840:913	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	6	27	contain	contains	1008:1015	arg1	one					1004:1006	The first commercial one	983:1006	The first commercial one	983:1006	The first commercial one contains single phosphorylation group, and the second contains two phosphorylation and two ketodeoxyoctonic acid (KDO) groups.
32720737	6	27	contain	contains	1008:1015	arg2	group					1040:1044	single phosphorylation group	1017:1044	single phosphorylation group	1017:1044	The first commercial one contains single phosphorylation group, and the second contains two phosphorylation and two ketodeoxyoctonic acid (KDO) groups.
32720737	9	28	theme	3-HPA	1581:1585	arg1	conditions					1484:1493	the best conditions	1475:1493	the best conditions to obtain a clear signal of both lipids A without prompt fragmentation	1475:1564	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	9	28	theme	3-HPA	1581:1585	arg1	use					1574:1576	the use	1570:1576	the use of 3-HPA	1570:1585	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	9	29	dep	fragmentation	1552:1564	arg1	prompt					1545:1550	prompt	1545:1550	prompt	1545:1550	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	4	30	theme	signal	725:730	arg1	suppression					710:720	the suppression	706:720	the suppression of signal	706:730	However, there are limitations with the matrix and additives used, such as the suppression of signal or prompt fragmentations that could give a false overview of lipid A composition in biological samples.
32720737	6	31	theme	phosphorylation	1024:1038	arg1	group					1040:1044	single phosphorylation group	1017:1044	single phosphorylation group	1017:1044	The first commercial one contains single phosphorylation group, and the second contains two phosphorylation and two ketodeoxyoctonic acid (KDO) groups.
32720737	2	32	theme	species	375:381	arg1	strains					355:361	strains	355:361	strains of the same species	355:381	As lipid A's structure differs among bacterial species and varies between strains of the same species, knowing its modifications is essential to understand its implications in the infectious process.
32720737	1	33	theme	virulence	270:278	arg1	factor					250:255	a key factor	244:255	a key factor of bacterial virulence	244:278	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	1	33	theme	virulence	270:278	arg1	compound					180:187	a major compound	172:187	a major compound of the outer membrane of gram-negative bacteria	172:235	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	1	33	theme	virulence	270:278	arg1	A					167:167	Lipid A	161:167	Lipid A	161:167	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	6	34	contain	contains	1062:1069	arg1	second					1055:1060	second	1055:1060	second	1055:1060	The first commercial one contains single phosphorylation group, and the second contains two phosphorylation and two ketodeoxyoctonic acid (KDO) groups.
32720737	6	34	contain	contains	1062:1069	arg2	two					1095:1097	two	1095:1097	two	1095:1097	The first commercial one contains single phosphorylation group, and the second contains two phosphorylation and two ketodeoxyoctonic acid (KDO) groups.
32720737	6	34	contain	contains	1062:1069	arg2	groups					1127:1132	two phosphorylation and two ketodeoxyoctonic acid (KDO) groups	1071:1132	groups	1127:1132	The first commercial one contains single phosphorylation group, and the second contains two phosphorylation and two ketodeoxyoctonic acid (KDO) groups.
32720737	2	35	theme	same	370:373	arg1	species					375:381	the same species	366:381	the same species	366:381	As lipid A's structure differs among bacterial species and varies between strains of the same species, knowing its modifications is essential to understand its implications in the infectious process.
32720737	7	36	dep	16	1324:1325	arg1	out					1313:1315	out	1313:1315	out	1313:1315	The lipid A containing KDO groups was essentially detected by the 3-hydroxypicolinic acid (3-HPA) matrix, whereas the monophosphorylated lipid A could be detected by 13 matrices out of the 16.
32720737	0	37	theme	ionization-mass	131:145	arg1	spectrometry					147:158	matrix-assisted laser desorption ionization-mass spectrometry	98:158	matrix-assisted laser desorption ionization-mass spectrometry	98:158	Effect of matrices and additives on phosphorylated and ketodeoxyoctonic acid lipids A analysis by matrix-assisted laser desorption ionization-mass spectrometry.
32720737	5	38	from	present	895:901	arg1	sample					908:913	a sample	906:913	a sample	906:913	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	6	39	theme	acid	1116:1119	arg1	groups					1127:1132	two phosphorylation and two ketodeoxyoctonic acid (KDO) groups	1071:1132	groups	1127:1132	The first commercial one contains single phosphorylation group, and the second contains two phosphorylation and two ketodeoxyoctonic acid (KDO) groups.
32720737	1	40	theme	outer	196:200	arg1	membrane					202:209	the outer membrane	192:209	the outer membrane of gram-negative bacteria	192:235	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	0	41	theme	matrices	10:17	arg1	Effect					0:5	Effect	0:5	Effect of matrices and additives on phosphorylated and ketodeoxyoctonic acid lipids	0:82	Effect of matrices and additives on phosphorylated and ketodeoxyoctonic acid lipids A analysis by matrix-assisted laser desorption ionization-mass spectrometry.
32720737	0	42	theme	desorption	120:129	arg1	spectrometry					147:158	matrix-assisted laser desorption ionization-mass spectrometry	98:158	matrix-assisted laser desorption ionization-mass spectrometry	98:158	Effect of matrices and additives on phosphorylated and ketodeoxyoctonic acid lipids A analysis by matrix-assisted laser desorption ionization-mass spectrometry.
32720737	8	43	theme	lipid	1385:1389	arg1	A					1391:1391	diphosphorylated lipid A	1368:1391	diphosphorylated lipid A	1368:1391	We also demonstrated that the signal of diphosphorylated lipid A can be enhanced with the use of additives in the matrix.
32720737	2	44	theme	A's	290:292	arg1	structure					294:302	lipid A's structure	284:302	lipid A's structure	284:302	As lipid A's structure differs among bacterial species and varies between strains of the same species, knowing its modifications is essential to understand its implications in the infectious process.
32720737	1	45	theme	membrane	202:209	arg1	factor					250:255	a key factor	244:255	a key factor of bacterial virulence	244:278	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	1	45	theme	membrane	202:209	arg1	compound					180:187	a major compound	172:187	a major compound of the outer membrane of gram-negative bacteria	172:235	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	1	45	theme	membrane	202:209	arg1	A					167:167	Lipid A	161:167	Lipid A	161:167	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	7	46	theme	lipid	1272:1276	arg1	A					1278:1278	the monophosphorylated lipid A	1249:1278	the monophosphorylated lipid A	1249:1278	The lipid A containing KDO groups was essentially detected by the 3-hydroxypicolinic acid (3-HPA) matrix, whereas the monophosphorylated lipid A could be detected by 13 matrices out of the 16.
32720737	7	47	theme	lipid	1139:1143	arg1	A					1145:1145	The lipid A	1135:1145	The lipid A containing KDO groups	1135:1167	The lipid A containing KDO groups was essentially detected by the 3-hydroxypicolinic acid (3-HPA) matrix, whereas the monophosphorylated lipid A could be detected by 13 matrices out of the 16.
32720737	7	48	theme	3-hydroxypicolinic	1201:1218	arg1	3-HPA					1226:1230	3-HPA	1226:1230	3-HPA	1226:1230	The lipid A containing KDO groups was essentially detected by the 3-hydroxypicolinic acid (3-HPA) matrix, whereas the monophosphorylated lipid A could be detected by 13 matrices out of the 16.
32720737	7	48	theme	3-hydroxypicolinic	1201:1218	arg1	acid					1220:1223	3-hydroxypicolinic acid	1201:1223	the 3-hydroxypicolinic acid (3-HPA) matrix	1197:1238	The lipid A containing KDO groups was essentially detected by the 3-hydroxypicolinic acid (3-HPA) matrix, whereas the monophosphorylated lipid A could be detected by 13 matrices out of the 16.
32720737	4	49	theme	A	799:799	arg1	composition					801:811	lipid A composition	793:811	lipid A composition	793:811	However, there are limitations with the matrix and additives used, such as the suppression of signal or prompt fragmentations that could give a false overview of lipid A composition in biological samples.
32720737	6	50	theme	single	1017:1022	arg1	group					1040:1044	single phosphorylation group	1017:1044	single phosphorylation group	1017:1044	The first commercial one contains single phosphorylation group, and the second contains two phosphorylation and two ketodeoxyoctonic acid (KDO) groups.
32720737	6	51	theme	commercial	993:1002	arg1	one					1004:1006	The first commercial one	983:1006	The first commercial one	983:1006	The first commercial one contains single phosphorylation group, and the second contains two phosphorylation and two ketodeoxyoctonic acid (KDO) groups.
32720737	0	52	theme	additives	23:31	arg1	Effect					0:5	Effect	0:5	Effect of matrices and additives on phosphorylated and ketodeoxyoctonic acid lipids	0:82	Effect of matrices and additives on phosphorylated and ketodeoxyoctonic acid lipids A analysis by matrix-assisted laser desorption ionization-mass spectrometry.
32720737	2	53	theme	infectious	461:470	arg1	process					472:478	the infectious process	457:478	the infectious process	457:478	As lipid A's structure differs among bacterial species and varies between strains of the same species, knowing its modifications is essential to understand its implications in the infectious process.
32720737	4	54	theme	lipid	793:797	arg1	composition					801:811	lipid A composition	793:811	lipid A composition	793:811	However, there are limitations with the matrix and additives used, such as the suppression of signal or prompt fragmentations that could give a false overview of lipid A composition in biological samples.
32720737	1	55	theme	gram-negative	214:226	arg1	bacteria					228:235	gram-negative bacteria	214:235	gram-negative bacteria	214:235	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	9	56	theme	best	1479:1482	arg1	conditions					1484:1493	the best conditions	1475:1493	the best conditions to obtain a clear signal of both lipids A without prompt fragmentation	1475:1564	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	9	56	theme	best	1479:1482	arg1	use					1574:1576	the use	1570:1576	the use of 3-HPA	1570:1585	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	6	57	theme	first	987:991	arg1	one					1004:1006	The first commercial one	983:1006	The first commercial one	983:1006	The first commercial one contains single phosphorylation group, and the second contains two phosphorylation and two ketodeoxyoctonic acid (KDO) groups.
32720737	4	58	with	limitations	650:660	arg1	suppression					710:720	the suppression	706:720	the suppression of signal	706:730	However, there are limitations with the matrix and additives used, such as the suppression of signal or prompt fragmentations that could give a false overview of lipid A composition in biological samples.
32720737	4	58	with	limitations	650:660	arg1	additives					682:690	the matrix and additives	667:690	additives	682:690	However, there are limitations with the matrix and additives used, such as the suppression of signal or prompt fragmentations that could give a false overview of lipid A composition in biological samples.
32720737	4	58	with	limitations	650:660	arg1	matrix					671:676	the matrix and additives	667:690	matrix	671:676	However, there are limitations with the matrix and additives used, such as the suppression of signal or prompt fragmentations that could give a false overview of lipid A composition in biological samples.
32720737	3	59	theme	well-suited	584:594	arg1	spectrometry					555:566	matrix-assisted laser desorption ionization-mass spectrometry	506:566	matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS)	506:577	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	59	theme	well-suited	584:594	arg1	method					596:601	a well-suited method	582:601	a well-suited method that is fast and efficient	582:628	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	59	theme	well-suited	584:594	arg1	fast					611:614	fast	611:614	fast	611:614	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	5	60	theme	species	887:893	arg1	analysis					856:863	a comprehensive analysis	840:863	a comprehensive analysis of the entire lipid A species present in a sample	840:913	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	0	61	theme	phosphorylated	36:49	arg1	lipids					77:82	phosphorylated and ketodeoxyoctonic acid lipids	36:82	phosphorylated and ketodeoxyoctonic acid lipids	36:82	Effect of matrices and additives on phosphorylated and ketodeoxyoctonic acid lipids A analysis by matrix-assisted laser desorption ionization-mass spectrometry.
32720737	9	62	theme	10mM	1592:1595	arg1	acid					1613:1616	10mM trifluoroacetic acid	1592:1616	10mM trifluoroacetic acid (TFA)	1592:1622	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	9	62	theme	10mM	1592:1595	arg1	TFA					1619:1621	TFA	1619:1621	TFA	1619:1621	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	4	63	theme	composition	801:811	arg1	overview					781:788	a false overview	773:788	a false overview of lipid A composition in biological samples	773:833	However, there are limitations with the matrix and additives used, such as the suppression of signal or prompt fragmentations that could give a false overview of lipid A composition in biological samples.
32720737	5	64	theme	present	895:901	arg1	species					887:893	the entire lipid A species	868:893	the entire lipid A species present in a sample	868:913	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	8	65	theme	diphosphorylated	1368:1383	arg1	A					1391:1391	diphosphorylated lipid A	1368:1391	diphosphorylated lipid A	1368:1391	We also demonstrated that the signal of diphosphorylated lipid A can be enhanced with the use of additives in the matrix.
32720737	7	66	theme	acid	1220:1223	arg1	matrix					1233:1238	the 3-hydroxypicolinic acid (3-HPA) matrix	1197:1238	the 3-hydroxypicolinic acid (3-HPA) matrix	1197:1238	The lipid A containing KDO groups was essentially detected by the 3-hydroxypicolinic acid (3-HPA) matrix, whereas the monophosphorylated lipid A could be detected by 13 matrices out of the 16.
32720737	4	67	theme	false	775:779	arg1	overview					781:788	a false overview	773:788	a false overview of lipid A composition in biological samples	773:833	However, there are limitations with the matrix and additives used, such as the suppression of signal or prompt fragmentations that could give a false overview of lipid A composition in biological samples.
32720737	7	68	contain	containing	1147:1156	arg1	A					1145:1145	The lipid A	1135:1145	The lipid A containing KDO groups	1135:1167	The lipid A containing KDO groups was essentially detected by the 3-hydroxypicolinic acid (3-HPA) matrix, whereas the monophosphorylated lipid A could be detected by 13 matrices out of the 16.
32720737	7	68	contain	containing	1147:1156	arg2	groups					1162:1167	KDO groups	1158:1167	KDO groups	1158:1167	The lipid A containing KDO groups was essentially detected by the 3-hydroxypicolinic acid (3-HPA) matrix, whereas the monophosphorylated lipid A could be detected by 13 matrices out of the 16.
32720737	6	69	theme	phosphorylation	1075:1089	arg1	groups					1127:1132	two phosphorylation and two ketodeoxyoctonic acid (KDO) groups	1071:1132	groups	1127:1132	The first commercial one contains single phosphorylation group, and the second contains two phosphorylation and two ketodeoxyoctonic acid (KDO) groups.
32720737	1	70	theme	bacteria	228:235	arg1	membrane					202:209	the outer membrane	192:209	the outer membrane of gram-negative bacteria	192:235	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	9	71	theme	lipids	1528:1533	arg1	signal					1513:1518	a clear signal	1505:1518	a clear signal of both lipids A without prompt fragmentation	1505:1564	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	2	72	theme	bacterial	318:326	arg1	species					328:334	bacterial species	318:334	bacterial species	318:334	As lipid A's structure differs among bacterial species and varies between strains of the same species, knowing its modifications is essential to understand its implications in the infectious process.
32720737	5	73	from	sample	908:913	arg1	present					895:901	present	895:901	present	895:901	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	9	74	with	use	1574:1576	arg1	acid					1613:1616	10mM trifluoroacetic acid	1592:1616	10mM trifluoroacetic acid (TFA)	1592:1622	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	9	74	with	use	1574:1576	arg1	TFA					1619:1621	TFA	1619:1621	TFA	1619:1621	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	0	75	theme	acid	72:75	arg1	lipids					77:82	phosphorylated and ketodeoxyoctonic acid lipids	36:82	phosphorylated and ketodeoxyoctonic acid lipids	36:82	Effect of matrices and additives on phosphorylated and ketodeoxyoctonic acid lipids A analysis by matrix-assisted laser desorption ionization-mass spectrometry.
32720737	5	76	theme	entire	872:877	arg1	species					887:893	the entire lipid A species	868:893	the entire lipid A species present in a sample	868:913	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	9	77	theme	clear	1507:1511	arg1	signal					1513:1518	a clear signal	1505:1518	a clear signal of both lipids A without prompt fragmentation	1505:1564	Our study indicated that the best conditions to obtain a clear signal of both lipids A without prompt fragmentation was the use of 3-HPA with 10mM trifluoroacetic acid (TFA).
32720737	4	78	from	overview	781:788	arg1	samples					827:833	biological samples	816:833	biological samples	816:833	However, there are limitations with the matrix and additives used, such as the suppression of signal or prompt fragmentations that could give a false overview of lipid A composition in biological samples.
32720737	1	79	theme	Lipid	161:165	arg1	A					167:167	Lipid A	161:167	Lipid A	161:167	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	1	79	theme	Lipid	161:165	arg1	compound					180:187	a major compound	172:187	a major compound of the outer membrane of gram-negative bacteria	172:235	Lipid A is a major compound of the outer membrane of gram-negative bacteria and is a key factor of bacterial virulence.
32720737	0	80	theme	ketodeoxyoctonic	55:70	arg1	lipids					77:82	phosphorylated and ketodeoxyoctonic acid lipids	36:82	phosphorylated and ketodeoxyoctonic acid lipids	36:82	Effect of matrices and additives on phosphorylated and ketodeoxyoctonic acid lipids A analysis by matrix-assisted laser desorption ionization-mass spectrometry.
32720737	5	81	attach	present	895:901	arg1	sample					908:913	a sample	906:913	a sample	906:913	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	5	81	attach	present	895:901	arg2	species					887:893	the entire lipid A species	868:893	the entire lipid A species present in a sample	868:913	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	5	82	theme	commercial	962:971	arg1	lipids					973:978	two commercial lipids	958:978	two commercial lipids A	958:980	For a comprehensive analysis of the entire lipid A species present in a sample, we tested 16 matrices and 11 additives on two commercial lipids A.
32720737	3	83	theme	laser	522:526	arg1	spectrometry					555:566	matrix-assisted laser desorption ionization-mass spectrometry	506:566	matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS)	506:577	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	83	theme	laser	522:526	arg1	fast					611:614	fast	611:614	fast	611:614	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	83	theme	laser	522:526	arg1	method					596:601	a well-suited method	582:601	a well-suited method that is fast and efficient	582:628	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
32720737	3	83	theme	laser	522:526	arg1	MALDI-MS					569:576	MALDI-MS	569:576	MALDI-MS	569:576	To analyze these lipids, matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is a well-suited method that is fast and efficient.
33831760	3	0	theme	adsorption	602:611	arg1	capacity					613:620	a high adsorption capacity	595:620	a high adsorption capacity on Pb(II) ions	595:635	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	3	1	theme	@	512:512	arg1	AM					513:514	SA@AM	510:514	SA@AM	510:514	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	5	2	theme	removal	916:922	arg1	%					965:965	more than 76%	953:965	more than 76%	953:965	Repeated adsorption desorption experiments showed that the removal ratio of Pb(II) by SA@AM was more than 76%, illustrating improved regeneration performance.
33831760	5	2	theme	removal	916:922	arg1	ratio					924:928	the removal ratio	912:928	the removal ratio of Pb(II) by SA@AM	912:947	Repeated adsorption desorption experiments showed that the removal ratio of Pb(II) by SA@AM was more than 76%, illustrating improved regeneration performance.
33831760	3	3	theme	heavy	659:663	arg1	pollutant					671:679	a common heavy metal pollutant	650:679	a common heavy metal pollutant	650:679	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	5	4	theme	SA	943:944	arg1	AM					946:947	SA@AM	943:947	SA@AM	943:947	Repeated adsorption desorption experiments showed that the removal ratio of Pb(II) by SA@AM was more than 76%, illustrating improved regeneration performance.
33831760	3	5	theme	metal	665:669	arg1	pollutant					671:679	a common heavy metal pollutant	650:679	a common heavy metal pollutant	650:679	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	4	6	theme	SA	841:842	arg1	surfaces					847:854	the SA@AM surfaces	837:854	the SA@AM surfaces	837:854	The Langmuir isotherm adsorption fits the adsorption curve, indicating uniform adsorption of Pb(II) on the SA@AM surfaces.
33831760	6	7	theme	magnetic	1095:1102	arg1	materials					1126:1134	bio-based green magnetic nano scale adsorption materials	1079:1134	bio-based green magnetic nano scale adsorption materials for environmental remediation applications	1079:1177	These results provide useful information for the production of bio-based green magnetic nano scale adsorption materials for environmental remediation applications.
33831760	2	8	theme	SA	330:331	arg1	AM					333:334	SA@AM	330:334	SA@AM	330:334	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	8	theme	SA	330:331	arg1	function					320:327	magnetic function	311:327	magnetic function (SA@AM)	311:335	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	9	theme	@	332:332	arg1	AM					333:334	SA@AM	330:334	SA@AM	330:334	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	9	theme	@	332:332	arg1	function					320:327	magnetic function	311:327	magnetic function (SA@AM)	311:335	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	3	10	theme	maximum	689:695	arg1	capacity					708:715	a maximum adsorption capacity	687:715	a maximum adsorption capacity of 105.8 mg g-1	687:731	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	6	11	theme	environmental	1140:1152	arg1	applications					1166:1177	environmental remediation applications	1140:1177	environmental remediation applications	1140:1177	These results provide useful information for the production of bio-based green magnetic nano scale adsorption materials for environmental remediation applications.
33831760	6	12	theme	scale	1109:1113	arg1	materials					1126:1134	bio-based green magnetic nano scale adsorption materials	1079:1134	bio-based green magnetic nano scale adsorption materials for environmental remediation applications	1079:1177	These results provide useful information for the production of bio-based green magnetic nano scale adsorption materials for environmental remediation applications.
33831760	6	13	theme	useful	1038:1043	arg1	information					1045:1055	useful information	1038:1055	useful information for the production of bio-based green magnetic nano scale adsorption materials for environmental remediation applications	1038:1177	These results provide useful information for the production of bio-based green magnetic nano scale adsorption materials for environmental remediation applications.
33831760	3	14	theme	adsorption	697:706	arg1	capacity					708:715	a maximum adsorption capacity	687:715	a maximum adsorption capacity of 105.8 mg g-1	687:731	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	4	15	theme	Pb	827:828	arg1	adsorption					813:822	uniform adsorption	805:822	uniform adsorption of Pb(II) on the SA@AM surfaces	805:854	The Langmuir isotherm adsorption fits the adsorption curve, indicating uniform adsorption of Pb(II) on the SA@AM surfaces.
33831760	5	16	theme	Pb	933:934	arg1	%					965:965	more than 76%	953:965	more than 76%	953:965	Repeated adsorption desorption experiments showed that the removal ratio of Pb(II) by SA@AM was more than 76%, illustrating improved regeneration performance.
33831760	5	16	theme	Pb	933:934	arg1	ratio					924:928	the removal ratio	912:928	the removal ratio of Pb(II) by SA@AM	912:947	Repeated adsorption desorption experiments showed that the removal ratio of Pb(II) by SA@AM was more than 76%, illustrating improved regeneration performance.
33831760	1	17	theme	much	195:198	arg1	attention					200:208	much attention	195:208	much attention	195:208	Polyelectrolyte composite nanospheres are relatively new adsorbents which have attracted much attention for their efficient pollutant removal and reuse performance.
33831760	2	18	theme	magnetic	311:318	arg1	AM					333:334	SA@AM	330:334	SA@AM	330:334	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	18	theme	magnetic	311:318	arg1	function					320:327	magnetic function	311:327	magnetic function (SA@AM)	311:335	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	3	19	from	capacity	613:620	arg1	ions					632:635	Pb(II) ions	625:635	Pb(II) ions	625:635	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	2	20	theme	terminal	459:466	arg1	AMs					504:506	AMs	504:506	AMs	504:506	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	20	theme	terminal	459:466	arg1	nanoparticles					489:501	terminal amino-based magnetic nanoparticles	459:501	a prepared terminal amino-based magnetic nanoparticles (AMs)	448:507	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	6	21	theme	green	1089:1093	arg1	materials					1126:1134	bio-based green magnetic nano scale adsorption materials	1079:1134	bio-based green magnetic nano scale adsorption materials for environmental remediation applications	1079:1177	These results provide useful information for the production of bio-based green magnetic nano scale adsorption materials for environmental remediation applications.
33831760	2	22	theme	prepared	450:457	arg1	AMs					504:506	AMs	504:506	AMs	504:506	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	22	theme	prepared	450:457	arg1	nanoparticles					489:501	terminal amino-based magnetic nanoparticles	459:501	a prepared terminal amino-based magnetic nanoparticles (AMs)	448:507	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	3	23	theme	105.8 mg g-1	720:731	arg1	capacity					708:715	a maximum adsorption capacity	687:715	a maximum adsorption capacity of 105.8 mg g-1	687:731	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	3	24	theme	magnetization	563:575	arg1	value					577:581	magnetization value	563:581	magnetization value	563:581	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	4	25	theme	Langmuir	738:745	arg1	adsorption					756:765	The Langmuir isotherm adsorption	734:765	The Langmuir isotherm adsorption	734:765	The Langmuir isotherm adsorption fits the adsorption curve, indicating uniform adsorption of Pb(II) on the SA@AM surfaces.
33831760	2	26	theme	sodium	408:413	arg1	SA					425:426	SA	425:426	SA	425:426	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	26	theme	sodium	408:413	arg1	alginate					415:422	the polyanionic sodium alginate	392:422	the polyanionic sodium alginate (SA)	392:427	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	0	27	theme	sodium	23:28	arg1	polyelectrolyte					39:53	magnetic sodium alginate polyelectrolyte	14:53	magnetic sodium alginate polyelectrolyte	14:53	Production of magnetic sodium alginate polyelectrolyte nanospheres for lead ions removal from wastewater.
33831760	3	28	theme	high	597:600	arg1	capacity					613:620	a high adsorption capacity	595:620	a high adsorption capacity on Pb(II) ions	595:635	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	1	29	theme	Polyelectrolyte	106:120	arg1	nanospheres					132:142	Polyelectrolyte composite nanospheres	106:142	Polyelectrolyte composite nanospheres	106:142	Polyelectrolyte composite nanospheres are relatively new adsorbents which have attracted much attention for their efficient pollutant removal and reuse performance.
33831760	1	29	theme	Polyelectrolyte	106:120	arg1	adsorbents					163:172	relatively new adsorbents	148:172	relatively new adsorbents which have attracted much attention for their efficient pollutant removal and reuse performance	148:268	Polyelectrolyte composite nanospheres are relatively new adsorbents which have attracted much attention for their efficient pollutant removal and reuse performance.
33831760	5	30	theme	@	945:945	arg1	AM					946:947	SA@AM	943:947	SA@AM	943:947	Repeated adsorption desorption experiments showed that the removal ratio of Pb(II) by SA@AM was more than 76%, illustrating improved regeneration performance.
33831760	1	31	theme	efficient	220:228	arg1	removal					240:246	their efficient pollutant removal	214:246	their efficient pollutant removal	214:246	Polyelectrolyte composite nanospheres are relatively new adsorbents which have attracted much attention for their efficient pollutant removal and reuse performance.
33831760	0	32	theme	magnetic	14:21	arg1	polyelectrolyte					39:53	magnetic sodium alginate polyelectrolyte	14:53	magnetic sodium alginate polyelectrolyte	14:53	Production of magnetic sodium alginate polyelectrolyte nanospheres for lead ions removal from wastewater.
33831760	6	33	theme	nano	1104:1107	arg1	materials					1126:1134	bio-based green magnetic nano scale adsorption materials	1079:1134	bio-based green magnetic nano scale adsorption materials for environmental remediation applications	1079:1177	These results provide useful information for the production of bio-based green magnetic nano scale adsorption materials for environmental remediation applications.
33831760	6	34	theme	adsorption	1115:1124	arg1	materials					1126:1134	bio-based green magnetic nano scale adsorption materials	1079:1134	bio-based green magnetic nano scale adsorption materials for environmental remediation applications	1079:1177	These results provide useful information for the production of bio-based green magnetic nano scale adsorption materials for environmental remediation applications.
33831760	1	35	theme	composite	122:130	arg1	nanospheres					132:142	Polyelectrolyte composite nanospheres	106:142	Polyelectrolyte composite nanospheres	106:142	Polyelectrolyte composite nanospheres are relatively new adsorbents which have attracted much attention for their efficient pollutant removal and reuse performance.
33831760	1	35	theme	composite	122:130	arg1	adsorbents					163:172	relatively new adsorbents	148:172	relatively new adsorbents which have attracted much attention for their efficient pollutant removal and reuse performance	148:268	Polyelectrolyte composite nanospheres are relatively new adsorbents which have attracted much attention for their efficient pollutant removal and reuse performance.
33831760	1	36	theme	pollutant	230:238	arg1	removal					240:246	their efficient pollutant removal	214:246	their efficient pollutant removal	214:246	Polyelectrolyte composite nanospheres are relatively new adsorbents which have attracted much attention for their efficient pollutant removal and reuse performance.
33831760	0	37	theme	polyelectrolyte	39:53	arg1	Production					0:9	Production	0:9	Production of magnetic sodium alginate polyelectrolyte	0:53	Production of magnetic sodium alginate polyelectrolyte nanospheres for lead ions removal from wastewater.
33831760	5	38	theme	adsorption	866:875	arg1	experiments					888:898	Repeated adsorption desorption experiments	857:898	Repeated adsorption desorption experiments	857:898	Repeated adsorption desorption experiments showed that the removal ratio of Pb(II) by SA@AM was more than 76%, illustrating improved regeneration performance.
33831760	5	39	theme	improved	981:988	arg1	performance					1003:1013	improved regeneration performance	981:1013	improved regeneration performance	981:1013	Repeated adsorption desorption experiments showed that the removal ratio of Pb(II) by SA@AM was more than 76%, illustrating improved regeneration performance.
33831760	4	40	theme	adsorption	776:785	arg1	curve					787:791	the adsorption curve	772:791	the adsorption curve	772:791	The Langmuir isotherm adsorption fits the adsorption curve, indicating uniform adsorption of Pb(II) on the SA@AM surfaces.
33831760	6	41	theme	materials	1126:1134	arg1	production					1065:1074	the production	1061:1074	the production of bio-based green magnetic nano scale adsorption materials for environmental remediation applications	1061:1177	These results provide useful information for the production of bio-based green magnetic nano scale adsorption materials for environmental remediation applications.
33831760	2	42	theme	nanoparticles	489:501	arg1	SA					425:426	SA	425:426	SA	425:426	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	42	theme	nanoparticles	489:501	arg1	alginate					415:422	the polyanionic sodium alginate	392:422	the polyanionic sodium alginate (SA)	392:427	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	42	theme	nanoparticles	489:501	arg1	surface					437:443	the surface	433:443	the surface of a prepared terminal amino-based magnetic nanoparticles (AMs)	433:507	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	0	43	theme	alginate	30:37	arg1	polyelectrolyte					39:53	magnetic sodium alginate polyelectrolyte	14:53	magnetic sodium alginate polyelectrolyte	14:53	Production of magnetic sodium alginate polyelectrolyte nanospheres for lead ions removal from wastewater.
33831760	3	44	theme	Pb	625:626	arg1	ions					632:635	Pb(II) ions	625:635	Pb(II) ions	625:635	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	4	45	from	adsorption	813:822	arg1	surfaces					847:854	the SA@AM surfaces	837:854	the SA@AM surfaces	837:854	The Langmuir isotherm adsorption fits the adsorption curve, indicating uniform adsorption of Pb(II) on the SA@AM surfaces.
33831760	2	46	theme	magnetic	480:487	arg1	AMs					504:506	AMs	504:506	AMs	504:506	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	46	theme	magnetic	480:487	arg1	nanoparticles					489:501	terminal amino-based magnetic nanoparticles	459:501	a prepared terminal amino-based magnetic nanoparticles (AMs)	448:507	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	4	47	theme	AM	844:845	arg1	surfaces					847:854	the SA@AM surfaces	837:854	the SA@AM surfaces	837:854	The Langmuir isotherm adsorption fits the adsorption curve, indicating uniform adsorption of Pb(II) on the SA@AM surfaces.
33831760	3	48	theme	value	577:581	arg1	emu·g-1					552:558	6.85 emu·g-1	547:558	6.85 emu·g-1 of magnetization value	547:581	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	2	49	theme	electrostatic	361:373	arg1	reaction					375:382	the electrostatic reaction	357:382	the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs)	357:507	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	50	theme	amino-based	468:478	arg1	AMs					504:506	AMs	504:506	AMs	504:506	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	50	theme	amino-based	468:478	arg1	nanoparticles					489:501	terminal amino-based magnetic nanoparticles	459:501	a prepared terminal amino-based magnetic nanoparticles (AMs)	448:507	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	4	51	theme	@	843:843	arg1	surfaces					847:854	the SA@AM surfaces	837:854	the SA@AM surfaces	837:854	The Langmuir isotherm adsorption fits the adsorption curve, indicating uniform adsorption of Pb(II) on the SA@AM surfaces.
33831760	4	52	theme	uniform	805:811	arg1	adsorption					813:822	uniform adsorption	805:822	uniform adsorption of Pb(II) on the SA@AM surfaces	805:854	The Langmuir isotherm adsorption fits the adsorption curve, indicating uniform adsorption of Pb(II) on the SA@AM surfaces.
33831760	3	53	theme	SA	510:511	arg1	AM					513:514	SA@AM	510:514	SA@AM	510:514	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	2	54	with	nanosphere	295:304	arg1	AM					333:334	SA@AM	330:334	SA@AM	330:334	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	54	with	nanosphere	295:304	arg1	function					320:327	magnetic function	311:327	magnetic function (SA@AM)	311:335	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	3	55	theme	common	652:657	arg1	pollutant					671:679	a common heavy metal pollutant	650:679	a common heavy metal pollutant	650:679	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	6	56	theme	remediation	1154:1164	arg1	applications					1166:1177	environmental remediation applications	1140:1177	environmental remediation applications	1140:1177	These results provide useful information for the production of bio-based green magnetic nano scale adsorption materials for environmental remediation applications.
33831760	5	57	theme	regeneration	990:1001	arg1	performance					1003:1013	improved regeneration performance	981:1013	improved regeneration performance	981:1013	Repeated adsorption desorption experiments showed that the removal ratio of Pb(II) by SA@AM was more than 76%, illustrating improved regeneration performance.
33831760	5	58	theme	desorption	877:886	arg1	experiments					888:898	Repeated adsorption desorption experiments	857:898	Repeated adsorption desorption experiments	857:898	Repeated adsorption desorption experiments showed that the removal ratio of Pb(II) by SA@AM was more than 76%, illustrating improved regeneration performance.
33831760	1	59	theme	reuse	252:256	arg1	performance					258:268	reuse performance	252:268	reuse performance	252:268	Polyelectrolyte composite nanospheres are relatively new adsorbents which have attracted much attention for their efficient pollutant removal and reuse performance.
33831760	4	60	theme	isotherm	747:754	arg1	adsorption					756:765	The Langmuir isotherm adsorption	734:765	The Langmuir isotherm adsorption	734:765	The Langmuir isotherm adsorption fits the adsorption curve, indicating uniform adsorption of Pb(II) on the SA@AM surfaces.
33831760	5	61	theme	Repeated	857:864	arg1	experiments					888:898	Repeated adsorption desorption experiments	857:898	Repeated adsorption desorption experiments	857:898	Repeated adsorption desorption experiments showed that the removal ratio of Pb(II) by SA@AM was more than 76%, illustrating improved regeneration performance.
33831760	3	62	theme	15-22 nm	533:540	arg1	size					525:528	a size	523:528	a size of 15-22 nm	523:540	SA@AM showed a size of 15-22 nm with 6.85 emu·g-1 of magnetization value, exhibiting a high adsorption capacity on Pb(II) ions representing a common heavy metal pollutant, with a maximum adsorption capacity of 105.8 mg g-1.
33831760	1	63	theme	new	159:161	arg1	nanospheres					132:142	Polyelectrolyte composite nanospheres	106:142	Polyelectrolyte composite nanospheres	106:142	Polyelectrolyte composite nanospheres are relatively new adsorbents which have attracted much attention for their efficient pollutant removal and reuse performance.
33831760	1	63	theme	new	159:161	arg1	adsorbents					163:172	relatively new adsorbents	148:172	relatively new adsorbents which have attracted much attention for their efficient pollutant removal and reuse performance	148:268	Polyelectrolyte composite nanospheres are relatively new adsorbents which have attracted much attention for their efficient pollutant removal and reuse performance.
33831760	0	64	theme	ions	76:79	arg1	removal					81:87	lead ions removal	71:87	lead ions removal from wastewater	71:103	Production of magnetic sodium alginate polyelectrolyte nanospheres for lead ions removal from wastewater.
33831760	0	65	from	wastewater	94:103	arg1	removal					81:87	lead ions removal	71:87	lead ions removal from wastewater	71:103	Production of magnetic sodium alginate polyelectrolyte nanospheres for lead ions removal from wastewater.
33831760	2	66	theme	polyelectrolyte	279:293	arg1	nanosphere					295:304	A novel polyelectrolyte nanosphere	271:304	A novel polyelectrolyte nanosphere with magnetic function (SA@AM)	271:335	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	67	theme	polyanionic	396:406	arg1	SA					425:426	SA	425:426	SA	425:426	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	2	67	theme	polyanionic	396:406	arg1	alginate					415:422	the polyanionic sodium alginate	392:422	the polyanionic sodium alginate (SA)	392:427	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33831760	6	68	theme	bio-based	1079:1087	arg1	materials					1126:1134	bio-based green magnetic nano scale adsorption materials	1079:1134	bio-based green magnetic nano scale adsorption materials for environmental remediation applications	1079:1177	These results provide useful information for the production of bio-based green magnetic nano scale adsorption materials for environmental remediation applications.
33831760	0	69	theme	lead	71:74	arg1	removal					81:87	lead ions removal	71:87	lead ions removal from wastewater	71:103	Production of magnetic sodium alginate polyelectrolyte nanospheres for lead ions removal from wastewater.
33831760	2	70	theme	novel	273:277	arg1	nanosphere					295:304	A novel polyelectrolyte nanosphere	271:304	A novel polyelectrolyte nanosphere with magnetic function (SA@AM)	271:335	A novel polyelectrolyte nanosphere with magnetic function (SA@AM) was synthesized via the electrostatic reaction between the polyanionic sodium alginate (SA) and the surface of a prepared terminal amino-based magnetic nanoparticles (AMs).
33556694	5	0	dep	phosphatis	1002:1011	arg1	Rhodocyclaceae					1048:1061	Rhodocyclaceae	1048:1061	Rhodocyclaceae	1048:1061	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	5	0	dep	phosphatis	1002:1011	arg1	to					1045:1046	to	1045:1046	to	1045:1046	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	5	0	dep	phosphatis	1002:1011	arg1	decreased					1014:1022	decreased	1014:1022	decreased from 37.4% to 13.9%	1014:1042	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	1	1	theme	accumulating	70:81	arg1	organisms					83:91	Glycogen accumulating organisms	61:91	Glycogen accumulating organisms (GAOs)	61:98	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	1	1	theme	accumulating	70:81	arg1	GAOs					94:97	GAOs	94:97	GAOs	94:97	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	10	2	theme	aerobic	1787:1793	arg1	phase					1795:1799	the aerobic phase	1783:1799	the aerobic phase	1783:1799	The presence of a novel PHA fraction (PHH) may disturb the microbial activity in the aerobic phase, where the GAO culture was more severely affected.
33556694	14	3	theme	above	2162:2166	arg1	results					2168:2174	All the above results	2154:2174	All the above results	2154:2174	All the above results indicate that butyrate could not be well metabolized by GAOs, but could provide PAOs a competitive advantage.
33556694	11	4	theme	Glycogen	1852:1859	arg1	cycling					1861:1867	Glycogen cycling	1852:1867	Glycogen cycling	1852:1867	Glycogen cycling also seemed to be limited in both reactors.
33556694	15	5	theme	EBPR	2381:2384	arg1	processes					2386:2394	EBPR processes	2381:2394	EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation	2381:2533	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	1	6	theme	biological	258:267	arg1	performance					295:305	enhanced biological phosphorus removal (EBPR) performance	249:305	enhanced biological phosphorus removal (EBPR) performance at high temperatures	249:326	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	15	7	dep	acetate	2309:2315	arg1	i.e.					2304:2307	i.e.	2304:2307	i.e.	2304:2307	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	15	8	theme	process	2517:2523	arg1	operation					2525:2533	successful process operation	2506:2533	successful process operation	2506:2533	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	7	9	theme	negative	1291:1298	arg1	impact					1300:1305	a negative impact	1289:1305	a negative impact	1289:1305	Nevertheless, butyrate had a negative impact on GAOs.
33556694	1	10	theme	carbon	195:200	arg1	sources					202:208	the often-limiting carbon sources	176:208	the often-limiting carbon sources available in wastewater	176:232	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	9	11	theme	synthesized	1600:1610	arg1	PHAs					1612:1615	synthesized PHAs	1600:1615	synthesized PHAs reduced in both PAO and GAO cultures	1600:1652	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	1	12	from	wastewater	223:232	arg1	available					210:218	available	210:218	available	210:218	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	4	13	from	EBPR	768:771	arg1	climates					785:792	tropical climates	776:792	tropical climates	776:792	The results of this study demonstrate that butyrate, as a supplemental or sole carbon source, could be promising for EBPR in tropical climates.
33556694	15	14	dep	VFAs	2298:2301	arg1	propionate					2318:2327	propionate	2318:2327	propionate	2318:2327	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	15	14	dep	VFAs	2298:2301	arg1	VFAs					2298:2301	mixed VFAs	2292:2301	mixed VFAs (i.e. acetate, propionate and butyrate)	2292:2341	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	15	14	dep	VFAs	2298:2301	arg1	acetate					2309:2315	acetate	2309:2315	acetate	2309:2315	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	15	14	dep	VFAs	2298:2301	arg1	butyrate					2333:2340	butyrate	2333:2340	butyrate	2333:2340	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	6	15	theme	P	1188:1188	arg1	performance					1198:1208	a relatively stable P removal performance	1168:1208	a relatively stable P removal performance	1168:1208	Thus, a relatively stable P removal performance was realized throughout the whole operation period.
33556694	8	16	dep	%	1465:1465	arg1	to					1467:1468	to	1467:1468	to	1467:1468	The biomass concentration and microbial diversity continually decreased in the GAO reactor, and Candidatus Competibacter phosphatis reduced from 27.3% to 6.2%, where the dominant population was replaced by Zoogloea.
33556694	5	17	theme	substantial	868:878	arg1	population					884:893	a substantial PAO population	866:893	a substantial PAO population	866:893	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	2	18	theme	fatty	482:486	arg1	butyrate					436:443	butyrate	436:443	butyrate	436:443	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	2	18	theme	fatty	482:486	arg1	VFA					494:496	VFA	494:496	VFA	494:496	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	2	18	theme	fatty	482:486	arg1	acid					488:491	volatile fatty acid	473:491	an important volatile fatty acid (VFA) produced in sludge fermentation	460:529	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	0	19	theme	tropical	42:49	arg1	climates					51:58	tropical climates	42:58	tropical climates	42:58	Butyrate can support PAOs but not GAOs in tropical climates.
33556694	3	20	theme	PAO-GAO	576:582	arg1	competition					584:594	the PAO-GAO competition	572:594	the PAO-GAO competition	572:594	Nevertheless, the impact of butyrate on the PAO-GAO competition is not well understood especially at high temperature.
33556694	9	21	theme	total	1584:1588	arg1	amount					1590:1595	the total amount	1580:1595	the total amount of synthesized PHAs reduced in both PAO and GAO cultures	1580:1652	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	9	21	theme	total	1584:1588	arg1	PHAs					1612:1615	synthesized PHAs	1600:1615	synthesized PHAs reduced in both PAO and GAO cultures	1600:1652	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	9	21	theme	total	1584:1588	arg1	PHA					1677:1679	PHA	1677:1679	PHA	1677:1679	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	2	22	theme	important	463:471	arg1	butyrate					436:443	butyrate	436:443	butyrate	436:443	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	2	22	theme	important	463:471	arg1	VFA					494:496	VFA	494:496	VFA	494:496	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	2	22	theme	important	463:471	arg1	acid					488:491	volatile fatty acid	473:491	an important volatile fatty acid (VFA) produced in sludge fermentation	460:529	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	1	23	from	available	210:218	arg1	wastewater					223:232	wastewater	223:232	wastewater	223:232	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	5	24	theme	phosphatis	1002:1011	arg1	abundance					963:971	the abundance	959:971	the abundance	959:971	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	1	25	theme	accumulating	142:153	arg1	PAOs					166:169	PAOs	166:169	PAOs	166:169	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	1	25	theme	accumulating	142:153	arg1	organisms					155:163	polyphosphate accumulating organisms	128:163	polyphosphate accumulating organisms (PAOs)	128:170	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	5	26	dep	%	1091:1091	arg1	to					1084:1085	to	1084:1085	to	1084:1085	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	4	27	theme	sole	725:728	arg1	source					737:742	a supplemental or sole carbon source	707:742	source	737:742	The results of this study demonstrate that butyrate, as a supplemental or sole carbon source, could be promising for EBPR in tropical climates.
33556694	15	28	theme	mixed	2292:2296	arg1	propionate					2318:2327	propionate	2318:2327	propionate	2318:2327	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	15	28	theme	mixed	2292:2296	arg1	VFAs					2298:2301	mixed VFAs	2292:2301	mixed VFAs (i.e. acetate, propionate and butyrate)	2292:2341	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	15	28	theme	mixed	2292:2296	arg1	acetate					2309:2315	acetate	2309:2315	acetate	2309:2315	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	15	28	theme	mixed	2292:2296	arg1	butyrate					2333:2340	butyrate	2333:2340	butyrate	2333:2340	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	8	29	theme	Competibacter	1423:1435	arg1	phosphatis					1437:1446	Candidatus Competibacter phosphatis	1412:1446	Candidatus Competibacter phosphatis	1412:1446	The biomass concentration and microbial diversity continually decreased in the GAO reactor, and Candidatus Competibacter phosphatis reduced from 27.3% to 6.2%, where the dominant population was replaced by Zoogloea.
33556694	2	30	theme	carbon	390:395	arg1	source					397:402	an additional carbon source	376:402	an additional carbon source supply	376:409	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	6	31	theme	operation	1244:1252	arg1	period					1254:1259	the whole operation period	1234:1259	the whole operation period	1234:1259	Thus, a relatively stable P removal performance was realized throughout the whole operation period.
33556694	12	32	from	metabolism	1939:1948	arg1	cultures					1958:1965	both cultures	1953:1965	both cultures	1953:1965	This could reduce the GAO metabolism in both cultures and favor PAOs and P removal.
33556694	1	33	theme	Glycogen	61:68	arg1	organisms					83:91	Glycogen accumulating organisms	61:91	Glycogen accumulating organisms (GAOs)	61:98	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	1	33	theme	Glycogen	61:68	arg1	GAOs					94:97	GAOs	94:97	GAOs	94:97	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	13	34	theme	culture	2045:2051	arg1	rate					2029:2032	the biomass growth rate	2010:2032	the biomass growth rate of the PAO culture	2010:2051	Furthermore, the biomass growth rate of the PAO culture was higher than that of GAO when fed with butyrate, which also provides PAO a competitive advantage.
33556694	13	34	theme	culture	2045:2051	arg1	higher					2057:2062	higher	2057:2062	higher	2057:2062	Furthermore, the biomass growth rate of the PAO culture was higher than that of GAO when fed with butyrate, which also provides PAO a competitive advantage.
33556694	1	35	theme	phosphorus	269:278	arg1	performance					295:305	enhanced biological phosphorus removal (EBPR) performance	249:305	enhanced biological phosphorus removal (EBPR) performance at high temperatures	249:326	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	8	36	theme	27.3	1461:1464	arg1	%					1465:1465	%	1465:1465	%	1465:1465	The biomass concentration and microbial diversity continually decreased in the GAO reactor, and Candidatus Competibacter phosphatis reduced from 27.3% to 6.2%, where the dominant population was replaced by Zoogloea.
33556694	2	37	theme	EBPR	414:417	arg1	processes					419:427	EBPR processes	414:427	EBPR processes	414:427	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	13	38	theme	PAO	2041:2043	arg1	culture					2045:2051	the PAO culture	2037:2051	the PAO culture	2037:2051	Furthermore, the biomass growth rate of the PAO culture was higher than that of GAO when fed with butyrate, which also provides PAO a competitive advantage.
33556694	5	39	dep	Rhodocyclaceae	1048:1061	arg1	increased					1064:1072	increased	1064:1072	increased from 2.0% to 14.5%	1064:1091	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	10	40	theme	novel	1720:1724	arg1	PHH					1740:1742	PHH	1740:1742	PHH	1740:1742	The presence of a novel PHA fraction (PHH) may disturb the microbial activity in the aerobic phase, where the GAO culture was more severely affected.
33556694	10	40	theme	novel	1720:1724	arg1	fraction					1730:1737	a novel PHA fraction	1718:1737	a novel PHA fraction (PHH)	1718:1743	The presence of a novel PHA fraction (PHH) may disturb the microbial activity in the aerobic phase, where the GAO culture was more severely affected.
33556694	15	41	theme	fractions	2464:2472	arg1	impact					2433:2438	the impact	2429:2438	the impact of substantial butyrate fractions	2429:2472	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	7	42	contain	had	1285:1287	arg1	butyrate					1276:1283	butyrate	1276:1283	butyrate	1276:1283	Nevertheless, butyrate had a negative impact on GAOs.
33556694	7	42	contain	had	1285:1287	arg2	impact					1300:1305	a negative impact	1289:1305	a negative impact	1289:1305	Nevertheless, butyrate had a negative impact on GAOs.
33556694	2	43	theme	volatile	473:480	arg1	butyrate					436:443	butyrate	436:443	butyrate	436:443	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	2	43	theme	volatile	473:480	arg1	VFA					494:496	VFA	494:496	VFA	494:496	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	2	43	theme	volatile	473:480	arg1	acid					488:491	volatile fatty acid	473:491	an important volatile fatty acid (VFA) produced in sludge fermentation	460:529	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	4	44	theme	tropical	776:783	arg1	climates					785:792	tropical climates	776:792	tropical climates	776:792	The results of this study demonstrate that butyrate, as a supplemental or sole carbon source, could be promising for EBPR in tropical climates.
33556694	15	45	theme	substantial	2443:2453	arg1	fractions					2464:2472	substantial butyrate fractions	2443:2472	substantial butyrate fractions	2443:2472	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	13	46	theme	growth	2022:2027	arg1	rate					2029:2032	the biomass growth rate	2010:2032	the biomass growth rate of the PAO culture	2010:2051	Furthermore, the biomass growth rate of the PAO culture was higher than that of GAO when fed with butyrate, which also provides PAO a competitive advantage.
33556694	13	46	theme	growth	2022:2027	arg1	higher					2057:2062	higher	2057:2062	higher	2057:2062	Furthermore, the biomass growth rate of the PAO culture was higher than that of GAO when fed with butyrate, which also provides PAO a competitive advantage.
33556694	8	47	theme	dominant	1486:1493	arg1	population					1495:1504	the dominant population	1482:1504	the dominant population	1482:1504	The biomass concentration and microbial diversity continually decreased in the GAO reactor, and Candidatus Competibacter phosphatis reduced from 27.3% to 6.2%, where the dominant population was replaced by Zoogloea.
33556694	10	48	theme	fraction	1730:1737	arg1	presence					1706:1713	The presence	1702:1713	The presence of a novel PHA fraction (PHH)	1702:1743	The presence of a novel PHA fraction (PHH) may disturb the microbial activity in the aerobic phase, where the GAO culture was more severely affected.
33556694	5	49	theme	important	1133:1141	arg1	role					1143:1146	an important role	1130:1146	an important role	1130:1146	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	14	50	theme	competitive	2263:2273	arg1	advantage					2275:2283	a competitive advantage	2261:2283	a competitive advantage	2261:2283	All the above results indicate that butyrate could not be well metabolized by GAOs, but could provide PAOs a competitive advantage.
33556694	6	51	theme	stable	1181:1186	arg1	performance					1198:1208	a relatively stable P removal performance	1168:1208	a relatively stable P removal performance	1168:1208	Thus, a relatively stable P removal performance was realized throughout the whole operation period.
33556694	15	52	from	PAOs	2363:2366	arg1	processes					2386:2394	EBPR processes	2381:2394	EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation	2381:2533	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	1	53	theme	enhanced	249:256	arg1	performance					295:305	enhanced biological phosphorus removal (EBPR) performance	249:305	enhanced biological phosphorus removal (EBPR) performance at high temperatures	249:326	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	9	54	theme	butyrate	1553:1560	arg1	addition					1541:1548	the addition	1537:1548	the addition of butyrate as carbon source	1537:1577	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	5	55	from	shift	950:954	arg1	abundance					963:971	the abundance	959:971	the abundance	959:971	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	5	56	theme	carbon	804:809	arg1	source					811:816	the carbon source	800:816	the carbon source	800:816	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	9	57	theme	carbon	1565:1570	arg1	source					1572:1577	carbon source	1565:1577	carbon source	1565:1577	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	5	58	theme	%	1082:1082	arg1	%					1091:1091	2.0% to 14.5%	1079:1091	2.0% to 14.5%	1079:1091	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	15	59	theme	successful	2506:2515	arg1	operation					2525:2533	successful process operation	2506:2533	successful process operation	2506:2533	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	12	60	dep	PAOs	1977:1980	arg1	removal					1988:1994	removal	1988:1994	removal	1988:1994	This could reduce the GAO metabolism in both cultures and favor PAOs and P removal.
33556694	6	61	theme	whole	1238:1242	arg1	period					1254:1259	the whole operation period	1234:1259	the whole operation period	1234:1259	Thus, a relatively stable P removal performance was realized throughout the whole operation period.
33556694	2	62	theme	sludge	511:516	arg1	fermentation					518:529	sludge fermentation	511:529	sludge fermentation	511:529	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	8	63	theme	microbial	1346:1354	arg1	diversity					1356:1364	microbial diversity	1346:1364	microbial diversity	1346:1364	The biomass concentration and microbial diversity continually decreased in the GAO reactor, and Candidatus Competibacter phosphatis reduced from 27.3% to 6.2%, where the dominant population was replaced by Zoogloea.
33556694	3	64	theme	butyrate	560:567	arg1	impact					550:555	the impact	546:555	the impact of butyrate on the PAO-GAO competition	546:594	Nevertheless, the impact of butyrate on the PAO-GAO competition is not well understood especially at high temperature.
33556694	1	65	theme	often-limiting	180:193	arg1	sources					202:208	the often-limiting carbon sources	176:208	the often-limiting carbon sources available in wastewater	176:232	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	10	66	from	activity	1771:1778	arg1	phase					1795:1799	the aerobic phase	1783:1799	the aerobic phase	1783:1799	The presence of a novel PHA fraction (PHH) may disturb the microbial activity in the aerobic phase, where the GAO culture was more severely affected.
33556694	12	67	theme	GAO	1935:1937	arg1	metabolism					1939:1948	the GAO metabolism	1931:1948	the GAO metabolism in both cultures	1931:1965	This could reduce the GAO metabolism in both cultures and favor PAOs and P removal.
33556694	5	68	theme	%	1033:1033	arg1	%					1042:1042	37.4% to 13.9%	1029:1042	37.4% to 13.9%	1029:1042	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	9	69	theme	PHAs	1612:1615	arg1	amount					1590:1595	the total amount	1580:1595	the total amount of synthesized PHAs reduced in both PAO and GAO cultures	1580:1652	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	9	69	theme	PHAs	1612:1615	arg1	PHAs					1612:1615	synthesized PHAs	1600:1615	synthesized PHAs reduced in both PAO and GAO cultures	1600:1652	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	9	69	theme	PHAs	1612:1615	arg1	PHA					1677:1679	PHA	1677:1679	PHA	1677:1679	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	9	69	theme	PHAs	1612:1615	arg1	composition					1662:1672	the composition	1658:1672	the composition of PHA	1658:1679	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	4	70	theme	study	671:675	arg1	results					655:661	The results	651:661	The results of this study	651:675	The results of this study demonstrate that butyrate, as a supplemental or sole carbon source, could be promising for EBPR in tropical climates.
33556694	10	71	theme	GAO	1812:1814	arg1	culture					1816:1822	the GAO culture	1808:1822	the GAO culture	1808:1822	The presence of a novel PHA fraction (PHH) may disturb the microbial activity in the aerobic phase, where the GAO culture was more severely affected.
33556694	6	72	theme	removal	1190:1196	arg1	performance					1198:1208	a relatively stable P removal performance	1168:1208	a relatively stable P removal performance	1168:1208	Thus, a relatively stable P removal performance was realized throughout the whole operation period.
33556694	8	73	theme	GAO	1395:1397	arg1	reactor					1399:1405	the GAO reactor	1391:1405	the GAO reactor	1391:1405	The biomass concentration and microbial diversity continually decreased in the GAO reactor, and Candidatus Competibacter phosphatis reduced from 27.3% to 6.2%, where the dominant population was replaced by Zoogloea.
33556694	9	74	theme	PAO	1633:1635	arg1	cultures					1645:1652	both PAO and GAO cultures	1628:1652	both PAO and GAO cultures	1628:1652	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	1	75	theme	polyphosphate	128:140	arg1	PAOs					166:169	PAOs	166:169	PAOs	166:169	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	1	75	theme	polyphosphate	128:140	arg1	organisms					155:163	polyphosphate accumulating organisms	128:163	polyphosphate accumulating organisms (PAOs)	128:170	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	9	76	theme	GAO	1641:1643	arg1	cultures					1645:1652	both PAO and GAO cultures	1628:1652	both PAO and GAO cultures	1628:1652	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	8	77	theme	Candidatus	1412:1421	arg1	phosphatis					1437:1446	Candidatus Competibacter phosphatis	1412:1446	Candidatus Competibacter phosphatis	1412:1446	The biomass concentration and microbial diversity continually decreased in the GAO reactor, and Candidatus Competibacter phosphatis reduced from 27.3% to 6.2%, where the dominant population was replaced by Zoogloea.
33556694	15	78	theme	warm	2408:2411	arg1	climates					2413:2420	warm climates	2408:2420	warm climates	2408:2420	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	2	79	used	used	360:363	arg2	liquids					342:348	Fermentation liquids	329:348	Fermentation liquids	329:348	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	4	80	theme	carbon	730:735	arg1	source					737:742	a supplemental or sole carbon source	707:742	source	737:742	The results of this study demonstrate that butyrate, as a supplemental or sole carbon source, could be promising for EBPR in tropical climates.
33556694	2	81	theme	additional	379:388	arg1	source					397:402	an additional carbon source	376:402	an additional carbon source supply	376:409	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	5	82	theme	PAO	880:882	arg1	population					884:893	a substantial PAO population	866:893	a substantial PAO population	866:893	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	14	83	dep	provide	2248:2254	arg1	PAOs					2256:2259	PAOs	2256:2259	PAOs	2256:2259	All the above results indicate that butyrate could not be well metabolized by GAOs, but could provide PAOs a competitive advantage.
33556694	9	84	theme	PHA	1677:1679	arg1	amount					1590:1595	the total amount	1580:1595	the total amount of synthesized PHAs reduced in both PAO and GAO cultures	1580:1652	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	9	84	theme	PHA	1677:1679	arg1	PHAs					1612:1615	synthesized PHAs	1600:1615	synthesized PHAs reduced in both PAO and GAO cultures	1600:1652	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	9	84	theme	PHA	1677:1679	arg1	PHA					1677:1679	PHA	1677:1679	PHA	1677:1679	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	9	84	theme	PHA	1677:1679	arg1	composition					1662:1672	the composition	1658:1672	the composition of PHA	1658:1679	With the addition of butyrate as carbon source, the total amount of synthesized PHAs reduced in both PAO and GAO cultures and the composition of PHA was greatly changed.
33556694	3	85	theme	high	633:636	arg1	temperature					638:648	high temperature	633:648	high temperature	633:648	Nevertheless, the impact of butyrate on the PAO-GAO competition is not well understood especially at high temperature.
33556694	3	86	from	impact	550:555	arg1	competition					584:594	the PAO-GAO competition	572:594	the PAO-GAO competition	572:594	Nevertheless, the impact of butyrate on the PAO-GAO competition is not well understood especially at high temperature.
33556694	1	87	theme	removal	280:286	arg1	performance					295:305	enhanced biological phosphorus removal (EBPR) performance	249:305	enhanced biological phosphorus removal (EBPR) performance at high temperatures	249:326	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	8	88	theme	6.2	1470:1472	arg1	%					1465:1465	%	1465:1465	%	1465:1465	The biomass concentration and microbial diversity continually decreased in the GAO reactor, and Candidatus Competibacter phosphatis reduced from 27.3% to 6.2%, where the dominant population was replaced by Zoogloea.
33556694	10	89	theme	PHA	1726:1728	arg1	PHH					1740:1742	PHH	1740:1742	PHH	1740:1742	The presence of a novel PHA fraction (PHH) may disturb the microbial activity in the aerobic phase, where the GAO culture was more severely affected.
33556694	10	89	theme	PHA	1726:1728	arg1	fraction					1730:1737	a novel PHA fraction	1718:1737	a novel PHA fraction (PHH)	1718:1743	The presence of a novel PHA fraction (PHH) may disturb the microbial activity in the aerobic phase, where the GAO culture was more severely affected.
33556694	15	90	theme	butyrate	2455:2462	arg1	fractions					2464:2472	substantial butyrate fractions	2443:2472	substantial butyrate fractions	2443:2472	Thus, mixed VFAs (i.e. acetate, propionate and butyrate) are likely to favor PAOs over GAOs in EBPR processes operated in warm climates, where the impact of substantial butyrate fractions represents an advantage towards successful process operation.
33556694	1	91	theme	EBPR	289:292	arg1	performance					295:305	enhanced biological phosphorus removal (EBPR) performance	249:305	enhanced biological phosphorus removal (EBPR) performance at high temperatures	249:326	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	5	92	dep	%	1042:1042	arg1	to					1035:1036	to	1035:1036	to	1035:1036	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	2	93	dep	source	397:402	arg1	supply					404:409	supply	404:409	an additional carbon source supply	376:409	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	1	94	from	temperatures	315:326	arg1	performance					295:305	enhanced biological phosphorus removal (EBPR) performance	249:305	enhanced biological phosphorus removal (EBPR) performance at high temperatures	249:326	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	13	95	theme	biomass	2014:2020	arg1	rate					2029:2032	the biomass growth rate	2010:2032	the biomass growth rate of the PAO culture	2010:2051	Furthermore, the biomass growth rate of the PAO culture was higher than that of GAO when fed with butyrate, which also provides PAO a competitive advantage.
33556694	13	95	theme	biomass	2014:2020	arg1	higher					2057:2062	higher	2057:2062	higher	2057:2062	Furthermore, the biomass growth rate of the PAO culture was higher than that of GAO when fed with butyrate, which also provides PAO a competitive advantage.
33556694	2	96	theme	Fermentation	329:340	arg1	liquids					342:348	Fermentation liquids	329:348	Fermentation liquids	329:348	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	1	97	theme	high	310:313	arg1	temperatures					315:326	high temperatures	310:326	high temperatures	310:326	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	13	98	theme	competitive	2131:2141	arg1	advantage					2143:2151	a competitive advantage	2129:2151	a competitive advantage	2129:2151	Furthermore, the biomass growth rate of the PAO culture was higher than that of GAO when fed with butyrate, which also provides PAO a competitive advantage.
33556694	1	99	theme	available	210:218	arg1	sources					202:208	the often-limiting carbon sources	176:208	the often-limiting carbon sources available in wastewater	176:232	Glycogen accumulating organisms (GAOs) are thought to compete with polyphosphate accumulating organisms (PAOs) for the often-limiting carbon sources available in wastewater, deteriorating enhanced biological phosphorus removal (EBPR) performance at high temperatures.
33556694	5	100	theme	substantial	938:948	arg1	shift					950:954	a substantial shift	936:954	a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal	936:1159	When the carbon source was gradually changed from acetate to butyrate, a substantial PAO population was found under both conditions, despite a substantial shift in the abundance of Candidatus Accumulibacter phosphatis (decreased from 37.4% to 13.9%) to Rhodocyclaceae (increased from 2.0% to 14.5%), where both organisms likely played an important role in P-removal.
33556694	2	101	from	source	397:402	arg1	processes					419:427	EBPR processes	414:427	EBPR processes	414:427	Fermentation liquids are often used to provide an additional carbon source supply in EBPR processes, where butyrate is known to be an important volatile fatty acid (VFA) produced in sludge fermentation.
33556694	10	102	theme	microbial	1761:1769	arg1	activity					1771:1778	the microbial activity	1757:1778	the microbial activity in the aerobic phase, where the GAO culture was more severely affected	1757:1849	The presence of a novel PHA fraction (PHH) may disturb the microbial activity in the aerobic phase, where the GAO culture was more severely affected.
33556694	8	103	theme	biomass	1320:1326	arg1	concentration					1328:1340	The biomass concentration	1316:1340	The biomass concentration	1316:1340	The biomass concentration and microbial diversity continually decreased in the GAO reactor, and Candidatus Competibacter phosphatis reduced from 27.3% to 6.2%, where the dominant population was replaced by Zoogloea.
32568403	2	0	theme	metabolic	381:389	arg1	output					391:396	poor metabolic output	376:396	poor metabolic output	376:396	Lower gut microbiota diversity and poor metabolic output are associated with undernutrition and new therapeutic paths may come from steering gut microbiota composition and functionality.
32568403	4	1	from	abundance	989:997	arg1	production					955:964	acetate and branched-chain fatty acid production	917:964	acetate and branched-chain fatty acid production	917:964	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	4	2	theme	acetate	917:923	arg1	production					955:964	acetate and branched-chain fatty acid production	917:964	acetate and branched-chain fatty acid production	917:964	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	3	3	theme	control	742:748	arg1	treatment					750:758	control treatment	742:758	control treatment	742:758	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	5	4	from	decrease	1200:1207	arg1	that					1212:1215	that	1212:1215	that	1212:1215	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
32568403	5	4	from	decrease	1200:1207	arg1	abundance					1184:1192	Bifidobacterium relative abundance	1159:1192	Bifidobacterium relative abundance	1159:1192	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
32568403	3	5	theme	Microbial	589:597	arg1	SHIME®					610:615	SHIME®	610:615	SHIME®	610:615	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	3	5	theme	Microbial	589:597	arg1	Ecosystem					599:607	Human Intestinal Microbial Ecosystem	572:607	Human Intestinal Microbial Ecosystem (SHIME®)	572:616	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	1	6	theme	under-five	305:314	arg1	proportion					322:331	an attributable under-five death proportion	289:331	an attributable under-five death proportion of 45%	289:338	Undernutrition remains a public health problem in the developing world with an attributable under-five death proportion of 45%.
32568403	9	7	dep	in	1669:1670	arg1	vivo					1672:1675	vivo	1672:1675	vivo	1672:1675	Further in vivo investigations are needed to assess these effects and their repercussion on nutritional status.
32568403	3	8	theme	Human	572:576	arg1	SHIME®					610:615	SHIME®	610:615	SHIME®	610:615	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	3	8	theme	Human	572:576	arg1	Ecosystem					599:607	Human Intestinal Microbial Ecosystem	572:607	Human Intestinal Microbial Ecosystem (SHIME®)	572:616	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	6	9	theme	Bilophila	1301:1309	arg1	sp					1311:1312	Bilophila sp	1301:1312	Bilophila sp	1301:1312	and Bilophila sp.
32568403	2	10	theme	Lower	341:345	arg1	diversity					362:370	Lower gut microbiota diversity	341:370	Lower gut microbiota diversity	341:370	Lower gut microbiota diversity and poor metabolic output are associated with undernutrition and new therapeutic paths may come from steering gut microbiota composition and functionality.
32568403	0	11	theme	acid	136:139	arg1	production					141:150	short-chain fatty acid production	118:150	short-chain fatty acid production in simulated colonic microbiota from undernourished infants	118:210	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	1	12	theme	public	238:243	arg1	problem					252:258	a public health problem	236:258	a public health problem in the developing world with an attributable under-five death proportion of 45%	236:338	Undernutrition remains a public health problem in the developing world with an attributable under-five death proportion of 45%.
32568403	9	13	from	repercussion	1737:1748	arg1	status					1765:1770	nutritional status	1753:1770	nutritional status	1753:1770	Further in vivo investigations are needed to assess these effects and their repercussion on nutritional status.
32568403	4	14	theme	branched-chain	929:942	arg1	acid					950:953	branched-chain fatty acid	929:953	branched-chain fatty acid	929:953	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	8	15	theme	prebiotic-enhanced	1497:1514	arg1	LNS					1516:1518	prebiotic-enhanced LNS	1497:1518	prebiotic-enhanced LNS	1497:1518	Our results suggest that provision of prebiotic-enhanced LNS to undernourished children could be a possible strategy to steer the microbiota toward a more beneficial composition and metabolic activity.
32568403	4	16	dep	genera	1006:1011	arg1	Megasphaera					1025:1035	Megasphaera	1025:1035	Megasphaera	1025:1035	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	4	16	dep	genera	1006:1011	arg1	Pseudomonas					1073:1083	Pseudomonas	1073:1083	Pseudomonas	1073:1083	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	4	16	dep	genera	1006:1011	arg1	Acidaminococcus					1053:1067	Acidaminococcus	1053:1067	Acidaminococcus	1053:1067	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	0	17	theme	colonic	165:171	arg1	microbiota					173:182	simulated colonic microbiota	155:182	simulated colonic microbiota from undernourished infants	155:210	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	4	18	theme	acid	950:953	arg1	production					955:964	acetate and branched-chain fatty acid production	917:964	acetate and branched-chain fatty acid production	917:964	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	3	19	theme	lipid-based	651:661	arg1	supplement					672:681	a lipid-based nutrient supplement	649:681	a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment,	649:759	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	4	20	theme	genera	1006:1011	arg1	abundance					989:997	a higher relative abundance	971:997	a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas	971:1083	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	4	20	theme	genera	1006:1011	arg1	increase					905:912	a significant increase	891:912	a significant increase in acetate and branched-chain fatty acid production	891:964	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	3	21	theme	fecal	811:815	arg1	microbiota					817:826	fecal microbiota	811:826	fecal microbiota	811:826	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	5	22	theme	Bifidobacterium	1159:1173	arg1	abundance					1184:1192	Bifidobacterium relative abundance	1159:1192	Bifidobacterium relative abundance	1159:1192	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
32568403	0	23	theme	relative	86:93	arg1	abundance					95:103	Bifidobacterium relative abundance	70:103	Bifidobacterium relative abundance	70:103	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	4	24	from	increase	905:912	arg1	production					955:964	acetate and branched-chain fatty acid production	917:964	acetate and branched-chain fatty acid production	917:964	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	4	25	theme	relative	980:987	arg1	abundance					989:997	a higher relative abundance	971:997	a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas	971:1083	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	8	26	theme	possible	1558:1565	arg1	provision					1484:1492	provision	1484:1492	provision of prebiotic-enhanced LNS to undernourished children	1484:1545	Our results suggest that provision of prebiotic-enhanced LNS to undernourished children could be a possible strategy to steer the microbiota toward a more beneficial composition and metabolic activity.
32568403	8	26	theme	possible	1558:1565	arg1	strategy					1567:1574	a possible strategy	1556:1574	a possible strategy to steer the microbiota toward a more beneficial composition and metabolic activity	1556:1658	Our results suggest that provision of prebiotic-enhanced LNS to undernourished children could be a possible strategy to steer the microbiota toward a more beneficial composition and metabolic activity.
32568403	5	27	theme	significant	1128:1138	arg1	increase					1147:1154	a significant 9-fold increase	1126:1154	a significant 9-fold increase in Bifidobacterium relative abundance	1126:1192	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
32568403	2	28	theme	new	437:439	arg1	paths					453:457	new therapeutic paths	437:457	new therapeutic paths	437:457	Lower gut microbiota diversity and poor metabolic output are associated with undernutrition and new therapeutic paths may come from steering gut microbiota composition and functionality.
32568403	0	29	theme	short-chain	118:128	arg1	acid					136:139	short-chain fatty acid	118:139	short-chain fatty acid production in simulated colonic microbiota from undernourished infants	118:210	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	7	30	theme	acetate	1393:1399	arg1	production					1379:1388	a significantly higher production	1356:1388	a significantly higher production of acetate, butyrate and propionate	1356:1424	Moreover, the LNSp treatment resulted in a significantly higher production of acetate, butyrate and propionate, as compared to control and LNS.
32568403	2	31	theme	microbiota	486:495	arg1	composition					497:507	gut microbiota composition	482:507	gut microbiota composition	482:507	Lower gut microbiota diversity and poor metabolic output are associated with undernutrition and new therapeutic paths may come from steering gut microbiota composition and functionality.
32568403	1	32	theme	death	316:320	arg1	proportion					322:331	an attributable under-five death proportion	289:331	an attributable under-five death proportion of 45%	289:338	Undernutrition remains a public health problem in the developing world with an attributable under-five death proportion of 45%.
32568403	3	33	from	infants	839:845	arg1	composition					768:778	composition	768:778	composition	768:778	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	3	33	from	infants	839:845	arg1	functionality					794:806	metabolic functionality	784:806	metabolic functionality	784:806	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	0	34	theme	lipid-based	21:31	arg1	LNSp					54:57	LNSp	54:57	LNSp	54:57	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	0	34	theme	lipid-based	21:31	arg1	supplement					42:51	A prebiotic-enhanced lipid-based nutrient supplement	0:51	A prebiotic-enhanced lipid-based nutrient supplement (LNSp)	0:58	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	1	35	with	problem	252:258	arg1	proportion					322:331	an attributable under-five death proportion	289:331	an attributable under-five death proportion of 45%	289:338	Undernutrition remains a public health problem in the developing world with an attributable under-five death proportion of 45%.
32568403	0	36	from	infants	204:210	arg1	microbiota					173:182	simulated colonic microbiota	155:182	simulated colonic microbiota from undernourished infants	155:210	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	0	36	from	infants	204:210	arg1	production					141:150	short-chain fatty acid production	118:150	short-chain fatty acid production in simulated colonic microbiota from undernourished infants	118:210	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	1	37	theme	%	338:338	arg1	proportion					322:331	an attributable under-five death proportion	289:331	an attributable under-five death proportion of 45%	289:338	Undernutrition remains a public health problem in the developing world with an attributable under-five death proportion of 45%.
32568403	9	38	theme	Further	1661:1667	arg1	investigations					1677:1690	Further in vivo investigations	1661:1690	Further in vivo investigations	1661:1690	Further in vivo investigations are needed to assess these effects and their repercussion on nutritional status.
32568403	3	39	theme	supplement	672:681	arg1	effect					639:644	the effect	635:644	the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition	635:875	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	3	40	theme	dynamic	536:542	arg1	model					548:552	a dynamic gut model	534:552	a dynamic gut model	534:552	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	3	40	theme	dynamic	536:542	arg1	Simulator					559:567	the Simulator	555:567	the Simulator of Human Intestinal Microbial Ecosystem (SHIME®)	555:616	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	8	41	theme	metabolic	1641:1649	arg1	activity					1651:1658	metabolic activity	1641:1658	metabolic activity	1641:1658	Our results suggest that provision of prebiotic-enhanced LNS to undernourished children could be a possible strategy to steer the microbiota toward a more beneficial composition and metabolic activity.
32568403	5	42	theme	Enterobacteriaceae	1273:1290	arg1	spp					1292:1294	Enterobacteriaceae spp	1273:1294	Enterobacteriaceae spp	1273:1294	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
32568403	2	43	dep	new	437:439	arg1	therapeutic					441:451	therapeutic	441:451	therapeutic	441:451	Lower gut microbiota diversity and poor metabolic output are associated with undernutrition and new therapeutic paths may come from steering gut microbiota composition and functionality.
32568403	1	44	theme	developing	267:276	arg1	world					278:282	the developing world	263:282	the developing world	263:282	Undernutrition remains a public health problem in the developing world with an attributable under-five death proportion of 45%.
32568403	5	45	theme	detrimental	1244:1254	arg1	spp					1292:1294	Enterobacteriaceae spp	1273:1294	Enterobacteriaceae spp	1273:1294	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
32568403	5	45	theme	detrimental	1244:1254	arg1	bacteria					1256:1263	detrimental bacteria	1244:1263	detrimental bacteria	1244:1263	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
32568403	4	46	theme	significant	893:903	arg1	increase					905:912	a significant increase	891:912	a significant increase in acetate and branched-chain fatty acid production	891:964	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	3	47	theme	Intestinal	578:587	arg1	SHIME®					610:615	SHIME®	610:615	SHIME®	610:615	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	3	47	theme	Intestinal	578:587	arg1	Ecosystem					599:607	Human Intestinal Microbial Ecosystem	572:607	Human Intestinal Microbial Ecosystem (SHIME®)	572:616	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	1	48	theme	attributable	292:303	arg1	proportion					322:331	an attributable under-five death proportion	289:331	an attributable under-five death proportion of 45%	289:338	Undernutrition remains a public health problem in the developing world with an attributable under-five death proportion of 45%.
32568403	2	49	theme	poor	376:379	arg1	output					391:396	poor metabolic output	376:396	poor metabolic output	376:396	Lower gut microbiota diversity and poor metabolic output are associated with undernutrition and new therapeutic paths may come from steering gut microbiota composition and functionality.
32568403	2	50	theme	gut	347:349	arg1	diversity					362:370	Lower gut microbiota diversity	341:370	Lower gut microbiota diversity	341:370	Lower gut microbiota diversity and poor metabolic output are associated with undernutrition and new therapeutic paths may come from steering gut microbiota composition and functionality.
32568403	9	51	theme	nutritional	1753:1763	arg1	status					1765:1770	nutritional status	1753:1770	nutritional status	1753:1770	Further in vivo investigations are needed to assess these effects and their repercussion on nutritional status.
32568403	3	52	theme	Ecosystem	599:607	arg1	model					548:552	a dynamic gut model	534:552	a dynamic gut model	534:552	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	3	52	theme	Ecosystem	599:607	arg1	Simulator					559:567	the Simulator	555:567	the Simulator of Human Intestinal Microbial Ecosystem (SHIME®)	555:616	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	0	53	theme	simulated	155:163	arg1	microbiota					173:182	simulated colonic microbiota	155:182	simulated colonic microbiota from undernourished infants	155:210	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	1	54	theme	health	245:250	arg1	problem					252:258	a public health problem	236:258	a public health problem in the developing world with an attributable under-five death proportion of 45%	236:338	Undernutrition remains a public health problem in the developing world with an attributable under-five death proportion of 45%.
32568403	9	55	from	effects	1719:1725	arg1	status					1765:1770	nutritional status	1753:1770	nutritional status	1753:1770	Further in vivo investigations are needed to assess these effects and their repercussion on nutritional status.
32568403	8	56	theme	LNS	1516:1518	arg1	provision					1484:1492	provision	1484:1492	provision of prebiotic-enhanced LNS to undernourished children	1484:1545	Our results suggest that provision of prebiotic-enhanced LNS to undernourished children could be a possible strategy to steer the microbiota toward a more beneficial composition and metabolic activity.
32568403	8	56	theme	LNS	1516:1518	arg1	strategy					1567:1574	a possible strategy	1556:1574	a possible strategy to steer the microbiota toward a more beneficial composition and metabolic activity	1556:1658	Our results suggest that provision of prebiotic-enhanced LNS to undernourished children could be a possible strategy to steer the microbiota toward a more beneficial composition and metabolic activity.
32568403	1	57	from	problem	252:258	arg1	world					278:282	the developing world	263:282	the developing world	263:282	Undernutrition remains a public health problem in the developing world with an attributable under-five death proportion of 45%.
32568403	8	58	theme	undernourished	1523:1536	arg1	children					1538:1545	undernourished children	1523:1545	undernourished children	1523:1545	Our results suggest that provision of prebiotic-enhanced LNS to undernourished children could be a possible strategy to steer the microbiota toward a more beneficial composition and metabolic activity.
32568403	3	59	theme	metabolic	784:792	arg1	functionality					794:806	metabolic functionality	784:806	metabolic functionality	784:806	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	0	60	theme	undernourished	189:202	arg1	infants					204:210	undernourished infants	189:210	undernourished infants	189:210	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	4	61	theme	fatty	944:948	arg1	acid					950:953	branched-chain fatty acid	929:953	branched-chain fatty acid	929:953	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	7	62	theme	propionate	1415:1424	arg1	production					1379:1388	a significantly higher production	1356:1388	a significantly higher production of acetate, butyrate and propionate	1356:1424	Moreover, the LNSp treatment resulted in a significantly higher production of acetate, butyrate and propionate, as compared to control and LNS.
32568403	0	63	theme	Bifidobacterium	70:84	arg1	abundance					95:103	Bifidobacterium relative abundance	70:103	Bifidobacterium relative abundance	70:103	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	5	64	theme	LNSp	1099:1102	arg1	treatment					1104:1112	LNSp treatment	1099:1112	LNSp treatment	1099:1112	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
32568403	7	65	theme	butyrate	1402:1409	arg1	production					1379:1388	a significantly higher production	1356:1388	a significantly higher production of acetate, butyrate and propionate	1356:1424	Moreover, the LNSp treatment resulted in a significantly higher production of acetate, butyrate and propionate, as compared to control and LNS.
32568403	3	66	theme	microbiota	817:826	arg1	composition					768:778	composition	768:778	composition	768:778	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	3	66	theme	microbiota	817:826	arg1	functionality					794:806	metabolic functionality	784:806	metabolic functionality	784:806	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	5	67	theme	relative	1175:1182	arg1	abundance					1184:1192	Bifidobacterium relative abundance	1159:1192	Bifidobacterium relative abundance	1159:1192	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
32568403	3	68	dep	composition	768:778	arg1	the					764:766	the	764:766	the	764:766	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	4	69	theme	higher	973:978	arg1	abundance					989:997	a higher relative abundance	971:997	a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas	971:1083	LNS elicited a significant increase in acetate and branched-chain fatty acid production, and a higher relative abundance of the genera Prevotella, Megasphaera, Acinetobacter, Acidaminococcus and Pseudomonas.
32568403	3	70	from	effect	639:644	arg1	composition					768:778	composition	768:778	composition	768:778	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	3	70	from	effect	639:644	arg1	functionality					794:806	metabolic functionality	784:806	metabolic functionality	784:806	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	0	71	theme	fatty	130:134	arg1	acid					136:139	short-chain fatty acid	118:139	short-chain fatty acid production in simulated colonic microbiota from undernourished infants	118:210	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	5	72	theme	9-fold	1140:1145	arg1	increase					1147:1154	a significant 9-fold increase	1126:1154	a significant 9-fold increase in Bifidobacterium relative abundance	1126:1192	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
32568403	0	73	theme	prebiotic-enhanced	2:19	arg1	LNSp					54:57	LNSp	54:57	LNSp	54:57	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	0	73	theme	prebiotic-enhanced	2:19	arg1	supplement					42:51	A prebiotic-enhanced lipid-based nutrient supplement	0:51	A prebiotic-enhanced lipid-based nutrient supplement (LNSp)	0:58	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	7	74	theme	higher	1372:1377	arg1	production					1379:1388	a significantly higher production	1356:1388	a significantly higher production of acetate, butyrate and propionate	1356:1424	Moreover, the LNSp treatment resulted in a significantly higher production of acetate, butyrate and propionate, as compared to control and LNS.
32568403	2	75	theme	gut	482:484	arg1	composition					497:507	gut microbiota composition	482:507	gut microbiota composition	482:507	Lower gut microbiota diversity and poor metabolic output are associated with undernutrition and new therapeutic paths may come from steering gut microbiota composition and functionality.
32568403	0	76	theme	nutrient	33:40	arg1	LNSp					54:57	LNSp	54:57	LNSp	54:57	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	0	76	theme	nutrient	33:40	arg1	supplement					42:51	A prebiotic-enhanced lipid-based nutrient supplement	0:51	A prebiotic-enhanced lipid-based nutrient supplement (LNSp)	0:58	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	5	77	theme	potential	1220:1228	arg1	spp					1292:1294	Enterobacteriaceae spp	1273:1294	Enterobacteriaceae spp	1273:1294	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
32568403	5	77	theme	potential	1220:1228	arg1	pathogens					1230:1238	potential pathogens	1220:1238	potential pathogens	1220:1238	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
32568403	8	78	theme	beneficial	1614:1623	arg1	composition					1625:1635	a more beneficial composition	1607:1635	a more beneficial composition	1607:1635	Our results suggest that provision of prebiotic-enhanced LNS to undernourished children could be a possible strategy to steer the microbiota toward a more beneficial composition and metabolic activity.
32568403	3	79	theme	nutrient	663:670	arg1	supplement					672:681	a lipid-based nutrient supplement	649:681	a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment,	649:759	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	9	80	theme	in	1669:1670	arg1	investigations					1677:1690	Further in vivo investigations	1661:1690	Further in vivo investigations	1661:1690	Further in vivo investigations are needed to assess these effects and their repercussion on nutritional status.
32568403	7	81	theme	LNSp	1329:1332	arg1	treatment					1334:1342	the LNSp treatment	1325:1342	the LNSp treatment	1325:1342	Moreover, the LNSp treatment resulted in a significantly higher production of acetate, butyrate and propionate, as compared to control and LNS.
32568403	3	82	theme	gut	544:546	arg1	model					548:552	a dynamic gut model	534:552	a dynamic gut model	534:552	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	3	82	theme	gut	544:546	arg1	Simulator					559:567	the Simulator	555:567	the Simulator of Human Intestinal Microbial Ecosystem (SHIME®)	555:616	Using a dynamic gut model, the Simulator of Human Intestinal Microbial Ecosystem (SHIME®), we investigated the effect of a lipid-based nutrient supplement enriched with prebiotics (LNSp), compared to LNS alone and control treatment, on the composition and metabolic functionality of fecal microbiota from three infants suffering from undernutrition.
32568403	2	83	theme	microbiota	351:360	arg1	diversity					362:370	Lower gut microbiota diversity	341:370	Lower gut microbiota diversity	341:370	Lower gut microbiota diversity and poor metabolic output are associated with undernutrition and new therapeutic paths may come from steering gut microbiota composition and functionality.
32568403	0	84	from	production	141:150	arg1	microbiota					173:182	simulated colonic microbiota	155:182	simulated colonic microbiota from undernourished infants	155:210	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	0	84	from	production	141:150	arg1	infants					204:210	undernourished infants	189:210	undernourished infants	189:210	A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants.
32568403	5	85	from	increase	1147:1154	arg1	that					1212:1215	that	1212:1215	that	1212:1215	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
32568403	5	85	from	increase	1147:1154	arg1	abundance					1184:1192	Bifidobacterium relative abundance	1159:1192	Bifidobacterium relative abundance	1159:1192	In contrast, LNSp treatment resulted in a significant 9-fold increase in Bifidobacterium relative abundance and a decrease in that of potential pathogens and detrimental bacteria such as Enterobacteriaceae spp.
34134074	7	0	theme	gram-negative	1079:1091	arg1	bacteria					1093:1100	gram-positive and gram-negative bacteria	1061:1100	gram-positive and gram-negative bacteria	1061:1100	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	1	1	theme	cinnamon	309:316	arg1	bark					318:321	cinnamon bark	309:321	cinnamon bark	309:321	Antimicrobial biocomposite films were prepared using agar (AG) and polyvinyl alcohol (PVA) as polymer matrix materials and cinnamon bark oil (CBO) as antimicrobial agent.
34134074	0	2	theme	relative	167:174	arg1	humidity					176:183	relative humidity	167:183	relative humidity	167:183	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	3	3	theme	water	451:455	arg1	properties					468:477	the overall water resistance properties	439:477	the overall water resistance properties of the composite films	439:500	The addition of AG improved the overall water resistance properties of the composite films.
34134074	4	4	theme	temperature	530:540	arg1	effects					519:525	the effects	515:525	the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films	515:609	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	0	5	theme	release	62:68	arg1	modeling					13:20	Mathematical modeling	0:20	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA	0:82	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	0	6	from	modeling	13:20	arg1	agar/PVA					75:82	agar/PVA	75:82	agar/PVA	75:82	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	2	7	theme	mixing	396:401	arg1	ratios					403:408	different mixing ratios	386:408	different mixing ratios	386:408	AG and PVA were blended with different mixing ratios.
34134074	3	8	theme	resistance	457:466	arg1	properties					468:477	the overall water resistance properties	439:477	the overall water resistance properties of the composite films	439:500	The addition of AG improved the overall water resistance properties of the composite films.
34134074	7	9	theme	antimicrobial	1024:1036	arg1	tests					1047:1051	In vitro antimicrobial activity tests	1015:1051	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria	1015:1100	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	7	10	theme	composite	1128:1136	arg1	films					1138:1142	the developed composite films	1114:1142	the developed composite films	1114:1142	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	7	11	theme	In	1015:1016	arg1	tests					1047:1051	In vitro antimicrobial activity tests	1015:1051	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria	1015:1100	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	3	12	theme	films	496:500	arg1	properties					468:477	the overall water resistance properties	439:477	the overall water resistance properties of the composite films	439:500	The addition of AG improved the overall water resistance properties of the composite films.
34134074	4	13	theme	relative	546:553	arg1	RH					565:566	RH	565:566	RH	565:566	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	4	13	theme	relative	546:553	arg1	humidity					555:562	relative humidity	546:562	relative humidity (RH)	546:567	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	0	14	theme	humidity	176:183	arg1	effects					140:146	The effects	136:146	The effects of temperature and relative humidity	136:183	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	7	15	theme	antimicrobial	1174:1186	arg1	applicability					1154:1166	high applicability	1149:1166	high applicability	1149:1166	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	7	15	theme	antimicrobial	1174:1186	arg1	material					1203:1210	an antimicrobial food packaging material	1171:1210	an antimicrobial food packaging material	1171:1210	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	4	16	from	films	605:609	arg1	CBO					596:598	CBO	596:598	CBO from films	596:609	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	4	16	from	films	605:609	arg1	kinetics					584:591	the release kinetics	572:591	the release kinetics of CBO from films	572:609	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	1	17	theme	polyvinyl	253:261	arg1	PVA					272:274	PVA	272:274	PVA	272:274	Antimicrobial biocomposite films were prepared using agar (AG) and polyvinyl alcohol (PVA) as polymer matrix materials and cinnamon bark oil (CBO) as antimicrobial agent.
34134074	1	17	theme	polyvinyl	253:261	arg1	alcohol					263:269	polyvinyl alcohol	253:269	polyvinyl alcohol (PVA)	253:275	Antimicrobial biocomposite films were prepared using agar (AG) and polyvinyl alcohol (PVA) as polymer matrix materials and cinnamon bark oil (CBO) as antimicrobial agent.
34134074	4	18	theme	release	616:622	arg1	kinetics					624:631	CBO release kinetics	612:631	CBO release kinetics	612:631	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	6	19	theme	release	990:996	arg1	behavior					998:1005	the release behavior	986:1005	the release behavior of CBO	986:1012	Consequently, the CBO release rate proportionally increased with the temperature and RH, with the RH being the main factor affecting the release behavior of CBO.
34134074	0	20	dep	biocomposite	84:95	arg1	effects					140:146	The effects	136:146	The effects of temperature and relative humidity	136:183	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	5	21	theme	CBO	848:850	arg1	mechanisms					834:843	the release mechanisms	822:843	the release mechanisms of CBO	822:850	Then, mathematical modeling of obtained data was conducted using Peleg, Ritger-Peppas, and Peppas-Sahlin models to investigate the release mechanisms of CBO.
34134074	4	22	theme	CBO	596:598	arg1	kinetics					584:591	the release kinetics	572:591	the release kinetics of CBO from films	572:609	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	7	23	theme	developed	1118:1126	arg1	films					1138:1142	the developed composite films	1114:1142	the developed composite films	1114:1142	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	5	24	theme	release	826:832	arg1	mechanisms					834:843	the release mechanisms	822:843	the release mechanisms of CBO	822:850	Then, mathematical modeling of obtained data was conducted using Peleg, Ritger-Peppas, and Peppas-Sahlin models to investigate the release mechanisms of CBO.
34134074	0	25	theme	Mathematical	0:11	arg1	modeling					13:20	Mathematical modeling	0:20	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA	0:82	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	4	26	from	effects	519:525	arg1	kinetics					584:591	the release kinetics	572:591	the release kinetics of CBO from films	572:609	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	7	27	theme	high	1149:1152	arg1	applicability					1154:1166	high applicability	1149:1166	high applicability	1149:1166	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	7	27	theme	high	1149:1152	arg1	material					1203:1210	an antimicrobial food packaging material	1171:1210	an antimicrobial food packaging material	1171:1210	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	7	28	theme	packaging	1193:1201	arg1	applicability					1154:1166	high applicability	1149:1166	high applicability	1149:1166	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	7	28	theme	packaging	1193:1201	arg1	material					1203:1210	an antimicrobial food packaging material	1171:1210	an antimicrobial food packaging material	1171:1210	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	5	29	theme	Peppas-Sahlin	786:798	arg1	models					800:805	Peleg, Ritger-Peppas, and Peppas-Sahlin models	760:805	models	800:805	Then, mathematical modeling of obtained data was conducted using Peleg, Ritger-Peppas, and Peppas-Sahlin models to investigate the release mechanisms of CBO.
34134074	1	30	theme	bark	318:321	arg1	CBO					328:330	CBO	328:330	CBO	328:330	Antimicrobial biocomposite films were prepared using agar (AG) and polyvinyl alcohol (PVA) as polymer matrix materials and cinnamon bark oil (CBO) as antimicrobial agent.
34134074	1	30	theme	bark	318:321	arg1	oil					323:325	polymer matrix materials and cinnamon bark oil	280:325	polymer matrix materials and cinnamon bark oil (CBO)	280:331	Antimicrobial biocomposite films were prepared using agar (AG) and polyvinyl alcohol (PVA) as polymer matrix materials and cinnamon bark oil (CBO) as antimicrobial agent.
34134074	4	31	from	kinetics	584:591	arg1	films					605:609	films	605:609	films	605:609	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	7	32	theme	activity	1038:1045	arg1	tests					1047:1051	In vitro antimicrobial activity tests	1015:1051	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria	1015:1100	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	0	33	theme	cinnamon	25:32	arg1	bark					53:56	cinnamon (Cinnamomum verum) bark	25:56	cinnamon (Cinnamomum verum) bark oil release from agar/PVA	25:82	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	5	34	theme	data	735:738	arg1	modeling					714:721	mathematical modeling	701:721	mathematical modeling of obtained data	701:738	Then, mathematical modeling of obtained data was conducted using Peleg, Ritger-Peppas, and Peppas-Sahlin models to investigate the release mechanisms of CBO.
34134074	0	35	theme	food	120:123	arg1	packaging					125:133	antimicrobial food packaging	106:133	antimicrobial food packaging	106:133	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	4	36	theme	temperature	675:685	arg1	combinations					659:670	the 9 combinations	653:670	the 9 combinations of temperature and RH	653:692	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	1	37	theme	Antimicrobial	186:198	arg1	films					213:217	Antimicrobial biocomposite films	186:217	Antimicrobial biocomposite films	186:217	Antimicrobial biocomposite films were prepared using agar (AG) and polyvinyl alcohol (PVA) as polymer matrix materials and cinnamon bark oil (CBO) as antimicrobial agent.
34134074	7	38	contain	have	1144:1147	arg2	applicability					1154:1166	high applicability	1149:1166	high applicability	1149:1166	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	7	38	contain	have	1144:1147	arg1	films					1138:1142	the developed composite films	1114:1142	the developed composite films	1114:1142	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	7	38	contain	have	1144:1147	arg2	material					1203:1210	an antimicrobial food packaging material	1171:1210	an antimicrobial food packaging material	1171:1210	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	0	39	theme	antimicrobial	106:118	arg1	packaging					125:133	antimicrobial food packaging	106:133	antimicrobial food packaging	106:133	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	1	40	theme	antimicrobial	336:348	arg1	agent					350:354	antimicrobial agent	336:354	antimicrobial agent	336:354	Antimicrobial biocomposite films were prepared using agar (AG) and polyvinyl alcohol (PVA) as polymer matrix materials and cinnamon bark oil (CBO) as antimicrobial agent.
34134074	0	41	dep	bark	53:56	arg1	verum					46:50	Cinnamomum verum	35:50	Cinnamomum verum	35:50	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	1	42	theme	biocomposite	200:211	arg1	films					213:217	Antimicrobial biocomposite films	186:217	Antimicrobial biocomposite films	186:217	Antimicrobial biocomposite films were prepared using agar (AG) and polyvinyl alcohol (PVA) as polymer matrix materials and cinnamon bark oil (CBO) as antimicrobial agent.
34134074	7	43	theme	gram-positive	1061:1073	arg1	bacteria					1093:1100	gram-positive and gram-negative bacteria	1061:1100	gram-positive and gram-negative bacteria	1061:1100	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	6	44	theme	release	875:881	arg1	rate					883:886	the CBO release rate	867:886	the CBO release rate	867:886	Consequently, the CBO release rate proportionally increased with the temperature and RH, with the RH being the main factor affecting the release behavior of CBO.
34134074	7	45	theme	food	1188:1191	arg1	applicability					1154:1166	high applicability	1149:1166	high applicability	1149:1166	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	7	45	theme	food	1188:1191	arg1	material					1203:1210	an antimicrobial food packaging material	1171:1210	an antimicrobial food packaging material	1171:1210	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
34134074	5	46	theme	mathematical	701:712	arg1	modeling					714:721	mathematical modeling	701:721	mathematical modeling of obtained data	701:738	Then, mathematical modeling of obtained data was conducted using Peleg, Ritger-Peppas, and Peppas-Sahlin models to investigate the release mechanisms of CBO.
34134074	6	47	theme	CBO	871:873	arg1	rate					883:886	the CBO release rate	867:886	the CBO release rate	867:886	Consequently, the CBO release rate proportionally increased with the temperature and RH, with the RH being the main factor affecting the release behavior of CBO.
34134074	2	48	theme	different	386:394	arg1	ratios					403:408	different mixing ratios	386:408	different mixing ratios	386:408	AG and PVA were blended with different mixing ratios.
34134074	4	49	theme	release	576:582	arg1	kinetics					584:591	the release kinetics	572:591	the release kinetics of CBO from films	572:609	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	1	50	theme	polymer	280:286	arg1	materials					295:303	polymer matrix materials	280:303	polymer matrix materials	280:303	Antimicrobial biocomposite films were prepared using agar (AG) and polyvinyl alcohol (PVA) as polymer matrix materials and cinnamon bark oil (CBO) as antimicrobial agent.
34134074	1	51	theme	matrix	288:293	arg1	materials					295:303	polymer matrix materials	280:303	polymer matrix materials	280:303	Antimicrobial biocomposite films were prepared using agar (AG) and polyvinyl alcohol (PVA) as polymer matrix materials and cinnamon bark oil (CBO) as antimicrobial agent.
34134074	3	52	theme	overall	443:449	arg1	properties					468:477	the overall water resistance properties	439:477	the overall water resistance properties of the composite films	439:500	The addition of AG improved the overall water resistance properties of the composite films.
34134074	1	53	theme	materials	295:303	arg1	CBO					328:330	CBO	328:330	CBO	328:330	Antimicrobial biocomposite films were prepared using agar (AG) and polyvinyl alcohol (PVA) as polymer matrix materials and cinnamon bark oil (CBO) as antimicrobial agent.
34134074	1	53	theme	materials	295:303	arg1	oil					323:325	polymer matrix materials and cinnamon bark oil	280:325	polymer matrix materials and cinnamon bark oil (CBO)	280:331	Antimicrobial biocomposite films were prepared using agar (AG) and polyvinyl alcohol (PVA) as polymer matrix materials and cinnamon bark oil (CBO) as antimicrobial agent.
34134074	0	54	theme	temperature	151:161	arg1	effects					140:146	The effects	136:146	The effects of temperature and relative humidity	136:183	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	3	55	theme	AG	427:428	arg1	addition					415:422	The addition	411:422	The addition of AG	411:428	The addition of AG improved the overall water resistance properties of the composite films.
34134074	3	56	theme	composite	486:494	arg1	films					496:500	the composite films	482:500	the composite films	482:500	The addition of AG improved the overall water resistance properties of the composite films.
34134074	4	57	theme	RH	691:692	arg1	combinations					659:670	the 9 combinations	653:670	the 9 combinations of temperature and RH	653:692	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	6	58	theme	CBO	1010:1012	arg1	behavior					998:1005	the release behavior	986:1005	the release behavior of CBO	986:1012	Consequently, the CBO release rate proportionally increased with the temperature and RH, with the RH being the main factor affecting the release behavior of CBO.
34134074	4	59	theme	humidity	555:562	arg1	effects					519:525	the effects	515:525	the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films	515:609	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	0	60	theme	oil	58:60	arg1	release					62:68	cinnamon (Cinnamomum verum) bark oil release	25:68	cinnamon (Cinnamomum verum) bark oil release from agar/PVA	25:82	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	0	61	from	agar/PVA	75:82	arg1	release					62:68	cinnamon (Cinnamomum verum) bark oil release	25:68	cinnamon (Cinnamomum verum) bark oil release from agar/PVA	25:82	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	0	61	from	agar/PVA	75:82	arg1	modeling					13:20	Mathematical modeling	0:20	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA	0:82	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	6	62	theme	main	964:967	arg1	RH					951:952	the RH	947:952	the RH	947:952	Consequently, the CBO release rate proportionally increased with the temperature and RH, with the RH being the main factor affecting the release behavior of CBO.
34134074	6	62	theme	main	964:967	arg1	factor					969:974	the main factor	960:974	the main factor affecting the release behavior of CBO	960:1012	Consequently, the CBO release rate proportionally increased with the temperature and RH, with the RH being the main factor affecting the release behavior of CBO.
34134074	4	63	theme	CBO	612:614	arg1	kinetics					624:631	CBO release kinetics	612:631	CBO release kinetics	612:631	To evaluate the effects of temperature and relative humidity (RH) on the release kinetics of CBO from films, CBO release kinetics were analyzed under the 9 combinations of temperature and RH.
34134074	0	64	theme	bark	53:56	arg1	release					62:68	cinnamon (Cinnamomum verum) bark oil release	25:68	cinnamon (Cinnamomum verum) bark oil release from agar/PVA	25:82	Mathematical modeling of cinnamon (Cinnamomum verum) bark oil release from agar/PVA biocomposite film for antimicrobial food packaging: The effects of temperature and relative humidity.
34134074	5	65	theme	obtained	726:733	arg1	data					735:738	obtained data	726:738	obtained data	726:738	Then, mathematical modeling of obtained data was conducted using Peleg, Ritger-Peppas, and Peppas-Sahlin models to investigate the release mechanisms of CBO.
34134074	7	66	dep	In	1015:1016	arg1	vitro					1018:1022	vitro	1018:1022	vitro	1018:1022	In vitro antimicrobial activity tests against gram-positive and gram-negative bacteria showed that the developed composite films have high applicability as an antimicrobial food packaging material.
33065525	8	0	theme	limit	1284:1288	arg1	0.025					1336:1340	0.025	1336:1340	0.025	1336:1340	Exploiting the one fluorophore per molecule labeling stoichiometry, the limit of detection (S/N > 3) and limit of quantitation (S/N > 10) were determined as 0.025 and 0.100 mg/mL, respectively, with good linearity.
33065525	8	0	theme	limit	1284:1288	arg1	0.100 mg/mL					1346:1356	0.100 mg/mL	1346:1356	0.100 mg/mL	1346:1356	Exploiting the one fluorophore per molecule labeling stoichiometry, the limit of detection (S/N > 3) and limit of quantitation (S/N > 10) were determined as 0.025 and 0.100 mg/mL, respectively, with good linearity.
33065525	8	0	theme	limit	1284:1288	arg1	limit					1251:1255	the limit	1247:1255	the limit of detection (S/N > 3) and limit of quantitation (S/N > 10)	1247:1315	Exploiting the one fluorophore per molecule labeling stoichiometry, the limit of detection (S/N > 3) and limit of quantitation (S/N > 10) were determined as 0.025 and 0.100 mg/mL, respectively, with good linearity.
33065525	7	1	theme	dextran	1166:1172	arg1	gel					1174:1176	the borate-buffered dextran gel	1146:1176	the borate-buffered dextran gel	1146:1176	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	7	2	theme	type	1079:1082	arg1	matrix					1108:1113	the conventional type carbohydrate separation matrix	1062:1113	the conventional type carbohydrate separation matrix	1062:1113	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	3	3	theme	gel	512:514	arg1	electrophoresis					516:530	multicapillary gel electrophoresis	497:530	multicapillary gel electrophoresis	497:530	In this paper an ultrafast high-resolution method is introduced for the separation of HMOs by multicapillary gel electrophoresis.
33065525	6	4	theme	borate-vicinal	868:881	arg1	complexation					888:899	the borate-vicinal diol complexation	864:899	the borate-vicinal diol complexation	864:899	The other one was a borate-buffered dextran gel, which utilized the secondary equilibrium of the borate-vicinal diol complexation to enhance resolution.
33065525	7	5	theme	rapid	940:944	arg1	time					955:958	the rapid analysis time	936:958	the rapid analysis time	936:958	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	7	6	with	80 min	1050:1055	arg1	matrix					1108:1113	the conventional type carbohydrate separation matrix	1062:1113	the conventional type carbohydrate separation matrix	1062:1113	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	5	7	theme	used	630:633	arg1	matrix					679:684	a conventionally used industrial standard carbohydrate separation matrix	613:684	a conventionally used industrial standard carbohydrate separation matrix	613:684	One was a conventionally used industrial standard carbohydrate separation matrix, resolving oligosaccharides according to their charge to hydrodynamic volume ratios.
33065525	5	7	theme	used	630:633	arg1	One					605:607	One	605:607	One	605:607	One was a conventionally used industrial standard carbohydrate separation matrix, resolving oligosaccharides according to their charge to hydrodynamic volume ratios.
33065525	7	8	theme	analysis	946:953	arg1	time					955:958	the rapid analysis time	936:958	the rapid analysis time	936:958	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	9	9	theme	several	1443:1449	arg1	HMOs					1469:1472	several low concentration HMOs	1443:1472	several low concentration HMOs	1443:1472	Based on the calibration plot, the quantities of several low concentration HMOs were determined from a human milk sample.
33065525	7	10	theme	borate-buffered	1150:1164	arg1	gel					1174:1176	the borate-buffered dextran gel	1146:1176	the borate-buffered dextran gel	1146:1176	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	5	11	theme	industrial	635:644	arg1	matrix					679:684	a conventionally used industrial standard carbohydrate separation matrix	613:684	a conventionally used industrial standard carbohydrate separation matrix	613:684	One was a conventionally used industrial standard carbohydrate separation matrix, resolving oligosaccharides according to their charge to hydrodynamic volume ratios.
33065525	5	11	theme	industrial	635:644	arg1	One					605:607	One	605:607	One	605:607	One was a conventionally used industrial standard carbohydrate separation matrix, resolving oligosaccharides according to their charge to hydrodynamic volume ratios.
33065525	3	12	theme	HMOs	489:492	arg1	separation					475:484	the separation	471:484	the separation of HMOs by multicapillary gel electrophoresis	471:530	In this paper an ultrafast high-resolution method is introduced for the separation of HMOs by multicapillary gel electrophoresis.
33065525	8	13	theme	labeling	1223:1230	arg1	stoichiometry					1232:1244	molecule labeling stoichiometry	1214:1244	molecule labeling stoichiometry	1214:1244	Exploiting the one fluorophore per molecule labeling stoichiometry, the limit of detection (S/N > 3) and limit of quantitation (S/N > 10) were determined as 0.025 and 0.100 mg/mL, respectively, with good linearity.
33065525	5	14	theme	carbohydrate	655:666	arg1	matrix					679:684	a conventionally used industrial standard carbohydrate separation matrix	613:684	a conventionally used industrial standard carbohydrate separation matrix	613:684	One was a conventionally used industrial standard carbohydrate separation matrix, resolving oligosaccharides according to their charge to hydrodynamic volume ratios.
33065525	5	14	theme	carbohydrate	655:666	arg1	One					605:607	One	605:607	One	605:607	One was a conventionally used industrial standard carbohydrate separation matrix, resolving oligosaccharides according to their charge to hydrodynamic volume ratios.
33065525	5	15	theme	standard	646:653	arg1	matrix					679:684	a conventionally used industrial standard carbohydrate separation matrix	613:684	a conventionally used industrial standard carbohydrate separation matrix	613:684	One was a conventionally used industrial standard carbohydrate separation matrix, resolving oligosaccharides according to their charge to hydrodynamic volume ratios.
33065525	5	15	theme	standard	646:653	arg1	One					605:607	One	605:607	One	605:607	One was a conventionally used industrial standard carbohydrate separation matrix, resolving oligosaccharides according to their charge to hydrodynamic volume ratios.
33065525	9	16	theme	low	1451:1453	arg1	HMOs					1469:1472	several low concentration HMOs	1443:1472	several low concentration HMOs	1443:1472	Based on the calibration plot, the quantities of several low concentration HMOs were determined from a human milk sample.
33065525	1	17	theme	baby	198:201	arg1	additives					211:219	baby formula additives	198:219	baby formula additives	198:219	There is recently growing interest towards synthesized human milk oligosaccharides (HMOs) as baby formula additives, and interestingly also as dietary supplements for adults.
33065525	9	18	theme	concentration	1455:1467	arg1	HMOs					1469:1472	several low concentration HMOs	1443:1472	several low concentration HMOs	1443:1472	Based on the calibration plot, the quantities of several low concentration HMOs were determined from a human milk sample.
33065525	8	19	theme	molecule	1214:1221	arg1	stoichiometry					1232:1244	molecule labeling stoichiometry	1214:1244	molecule labeling stoichiometry	1214:1244	Exploiting the one fluorophore per molecule labeling stoichiometry, the limit of detection (S/N > 3) and limit of quantitation (S/N > 10) were determined as 0.025 and 0.100 mg/mL, respectively, with good linearity.
33065525	5	20	theme	separation	668:677	arg1	matrix					679:684	a conventionally used industrial standard carbohydrate separation matrix	613:684	a conventionally used industrial standard carbohydrate separation matrix	613:684	One was a conventionally used industrial standard carbohydrate separation matrix, resolving oligosaccharides according to their charge to hydrodynamic volume ratios.
33065525	5	20	theme	separation	668:677	arg1	One					605:607	One	605:607	One	605:607	One was a conventionally used industrial standard carbohydrate separation matrix, resolving oligosaccharides according to their charge to hydrodynamic volume ratios.
33065525	6	21	theme	secondary	839:847	arg1	equilibrium					849:859	the secondary equilibrium	835:859	the secondary equilibrium of the borate-vicinal diol complexation	835:899	The other one was a borate-buffered dextran gel, which utilized the secondary equilibrium of the borate-vicinal diol complexation to enhance resolution.
33065525	8	22	theme	good	1378:1381	arg1	linearity					1383:1391	good linearity	1378:1391	good linearity	1378:1391	Exploiting the one fluorophore per molecule labeling stoichiometry, the limit of detection (S/N > 3) and limit of quantitation (S/N > 10) were determined as 0.025 and 0.100 mg/mL, respectively, with good linearity.
33065525	6	23	used	utilized	826:833	arg2	gel					815:817	a borate-buffered dextran gel	789:817	a borate-buffered dextran gel	789:817	The other one was a borate-buffered dextran gel, which utilized the secondary equilibrium of the borate-vicinal diol complexation to enhance resolution.
33065525	6	23	used	utilized	826:833	arg2	one					781:783	one	781:783	one	781:783	The other one was a borate-buffered dextran gel, which utilized the secondary equilibrium of the borate-vicinal diol complexation to enhance resolution.
33065525	0	24	theme	high-resolution	10:24	arg1	analysis					26:33	Ultrafast high-resolution analysis	0:33	Ultrafast high-resolution analysis of human milk	0:47	Ultrafast high-resolution analysis of human milk oligosaccharides by multicapillary gel electrophoresis.
33065525	4	25	theme	resolving	588:596	arg1	power					598:602	complementary resolving power	574:602	complementary resolving power	574:602	Two gel compositions were evaluated with complementary resolving power.
33065525	7	26	theme	96	1000:1001	arg1	well					1003:1006	well	1003:1006	well	1003:1006	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	3	27	theme	ultrafast	420:428	arg1	method					446:451	an ultrafast high-resolution method	417:451	an ultrafast high-resolution method	417:451	In this paper an ultrafast high-resolution method is introduced for the separation of HMOs by multicapillary gel electrophoresis.
33065525	0	28	theme	Ultrafast	0:8	arg1	analysis					26:33	Ultrafast high-resolution analysis	0:33	Ultrafast high-resolution analysis of human milk	0:47	Ultrafast high-resolution analysis of human milk oligosaccharides by multicapillary gel electrophoresis.
33065525	4	29	theme	complementary	574:586	arg1	power					598:602	complementary resolving power	574:602	complementary resolving power	574:602	Two gel compositions were evaluated with complementary resolving power.
33065525	3	30	theme	high-resolution	430:444	arg1	method					446:451	an ultrafast high-resolution method	417:451	an ultrafast high-resolution method	417:451	In this paper an ultrafast high-resolution method is introduced for the separation of HMOs by multicapillary gel electrophoresis.
33065525	7	31	theme	well	1003:1006	arg1	plate					1015:1019	a 96 well sample plate	998:1019	a 96 well sample plate	998:1019	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	5	32	theme	volume	756:761	arg1	ratios					763:768	hydrodynamic volume ratios	743:768	hydrodynamic volume ratios	743:768	One was a conventionally used industrial standard carbohydrate separation matrix, resolving oligosaccharides according to their charge to hydrodynamic volume ratios.
33065525	7	33	theme	sample	1008:1013	arg1	plate					1015:1019	a 96 well sample plate	998:1019	a 96 well sample plate	998:1019	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	8	34	theme	detection	1260:1268	arg1	0.025					1336:1340	0.025	1336:1340	0.025	1336:1340	Exploiting the one fluorophore per molecule labeling stoichiometry, the limit of detection (S/N > 3) and limit of quantitation (S/N > 10) were determined as 0.025 and 0.100 mg/mL, respectively, with good linearity.
33065525	8	34	theme	detection	1260:1268	arg1	0.100 mg/mL					1346:1356	0.100 mg/mL	1346:1356	0.100 mg/mL	1346:1356	Exploiting the one fluorophore per molecule labeling stoichiometry, the limit of detection (S/N > 3) and limit of quantitation (S/N > 10) were determined as 0.025 and 0.100 mg/mL, respectively, with good linearity.
33065525	8	34	theme	detection	1260:1268	arg1	limit					1251:1255	the limit	1247:1255	the limit of detection (S/N > 3) and limit of quantitation (S/N > 10)	1247:1315	Exploiting the one fluorophore per molecule labeling stoichiometry, the limit of detection (S/N > 3) and limit of quantitation (S/N > 10) were determined as 0.025 and 0.100 mg/mL, respectively, with good linearity.
33065525	8	35	theme	quantitation	1293:1304	arg1	limit					1284:1288	limit	1284:1288	limit of quantitation (S/N > 10)	1284:1315	Exploiting the one fluorophore per molecule labeling stoichiometry, the limit of detection (S/N > 3) and limit of quantitation (S/N > 10) were determined as 0.025 and 0.100 mg/mL, respectively, with good linearity.
33065525	8	35	theme	quantitation	1293:1304	arg1	detection					1260:1268	detection	1260:1268	detection (S/N > 3)	1260:1278	Exploiting the one fluorophore per molecule labeling stoichiometry, the limit of detection (S/N > 3) and limit of quantitation (S/N > 10) were determined as 0.025 and 0.100 mg/mL, respectively, with good linearity.
33065525	8	35	theme	quantitation	1293:1304	arg1	S/N > 3					1271:1277	S/N > 3	1271:1277	S/N > 3	1271:1277	Exploiting the one fluorophore per molecule labeling stoichiometry, the limit of detection (S/N > 3) and limit of quantitation (S/N > 10) were determined as 0.025 and 0.100 mg/mL, respectively, with good linearity.
33065525	0	36	theme	milk	44:47	arg1	analysis					26:33	Ultrafast high-resolution analysis	0:33	Ultrafast high-resolution analysis of human milk	0:47	Ultrafast high-resolution analysis of human milk oligosaccharides by multicapillary gel electrophoresis.
33065525	3	37	theme	multicapillary	497:510	arg1	electrophoresis					516:530	multicapillary gel electrophoresis	497:530	multicapillary gel electrophoresis	497:530	In this paper an ultrafast high-resolution method is introduced for the separation of HMOs by multicapillary gel electrophoresis.
33065525	1	38	theme	formula	203:209	arg1	additives					211:219	baby formula additives	198:219	baby formula additives	198:219	There is recently growing interest towards synthesized human milk oligosaccharides (HMOs) as baby formula additives, and interestingly also as dietary supplements for adults.
33065525	9	39	theme	human	1497:1501	arg1	sample					1508:1513	a human milk sample	1495:1513	a human milk sample	1495:1513	Based on the calibration plot, the quantities of several low concentration HMOs were determined from a human milk sample.
33065525	0	40	theme	human	38:42	arg1	milk					44:47	human milk	38:47	human milk	38:47	Ultrafast high-resolution analysis of human milk oligosaccharides by multicapillary gel electrophoresis.
33065525	9	41	theme	milk	1503:1506	arg1	sample					1508:1513	a human milk sample	1495:1513	a human milk sample	1495:1513	Based on the calibration plot, the quantities of several low concentration HMOs were determined from a human milk sample.
33065525	4	42	theme	gel	537:539	arg1	compositions					541:552	Two gel compositions	533:552	Two gel compositions	533:552	Two gel compositions were evaluated with complementary resolving power.
33065525	7	43	theme	carbohydrate	1084:1095	arg1	matrix					1108:1113	the conventional type carbohydrate separation matrix	1062:1113	the conventional type carbohydrate separation matrix	1062:1113	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	7	44	theme	separation	1097:1106	arg1	matrix					1108:1113	the conventional type carbohydrate separation matrix	1062:1113	the conventional type carbohydrate separation matrix	1062:1113	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	6	45	theme	dextran	807:813	arg1	gel					815:817	a borate-buffered dextran gel	789:817	a borate-buffered dextran gel	789:817	The other one was a borate-buffered dextran gel, which utilized the secondary equilibrium of the borate-vicinal diol complexation to enhance resolution.
33065525	6	45	theme	dextran	807:813	arg1	one					781:783	one	781:783	one	781:783	The other one was a borate-buffered dextran gel, which utilized the secondary equilibrium of the borate-vicinal diol complexation to enhance resolution.
33065525	2	46	dep	synthesize	316:325	arg1	both					373:376	both	373:376	both	373:376	Currently quite a few manufacturers synthesize HMOs, however, their analysis is challenging, both in resolution and speed.
33065525	7	47	theme	12-channel	978:987	arg1	multiplexing					964:975	multiplexing	964:975	multiplexing (12-channel system)	964:995	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	7	47	theme	12-channel	978:987	arg1	system					989:994	12-channel system	978:994	12-channel system	978:994	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	7	48	theme	conventional	1066:1077	arg1	matrix					1108:1113	the conventional type carbohydrate separation matrix	1062:1113	the conventional type carbohydrate separation matrix	1062:1113	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	6	49	theme	borate-buffered	791:805	arg1	gel					815:817	a borate-buffered dextran gel	789:817	a borate-buffered dextran gel	789:817	The other one was a borate-buffered dextran gel, which utilized the secondary equilibrium of the borate-vicinal diol complexation to enhance resolution.
33065525	6	49	theme	borate-buffered	791:805	arg1	one					781:783	one	781:783	one	781:783	The other one was a borate-buffered dextran gel, which utilized the secondary equilibrium of the borate-vicinal diol complexation to enhance resolution.
33065525	1	50	theme	synthesized	148:158	arg1	oligosaccharides					171:186	synthesized human milk oligosaccharides	148:186	synthesized human milk oligosaccharides (HMOs) as baby formula additives	148:219	There is recently growing interest towards synthesized human milk oligosaccharides (HMOs) as baby formula additives, and interestingly also as dietary supplements for adults.
33065525	1	50	theme	synthesized	148:158	arg1	HMOs					189:192	HMOs	189:192	HMOs	189:192	There is recently growing interest towards synthesized human milk oligosaccharides (HMOs) as baby formula additives, and interestingly also as dietary supplements for adults.
33065525	9	51	theme	calibration	1407:1417	arg1	plot					1419:1422	the calibration plot	1403:1422	the calibration plot	1403:1422	Based on the calibration plot, the quantities of several low concentration HMOs were determined from a human milk sample.
33065525	5	52	theme	hydrodynamic	743:754	arg1	ratios					763:768	hydrodynamic volume ratios	743:768	hydrodynamic volume ratios	743:768	One was a conventionally used industrial standard carbohydrate separation matrix, resolving oligosaccharides according to their charge to hydrodynamic volume ratios.
33065525	6	53	theme	complexation	888:899	arg1	equilibrium					849:859	the secondary equilibrium	835:859	the secondary equilibrium of the borate-vicinal diol complexation	835:899	The other one was a borate-buffered dextran gel, which utilized the secondary equilibrium of the borate-vicinal diol complexation to enhance resolution.
33065525	1	54	theme	human	160:164	arg1	oligosaccharides					171:186	synthesized human milk oligosaccharides	148:186	synthesized human milk oligosaccharides (HMOs) as baby formula additives	148:219	There is recently growing interest towards synthesized human milk oligosaccharides (HMOs) as baby formula additives, and interestingly also as dietary supplements for adults.
33065525	1	54	theme	human	160:164	arg1	HMOs					189:192	HMOs	189:192	HMOs	189:192	There is recently growing interest towards synthesized human milk oligosaccharides (HMOs) as baby formula additives, and interestingly also as dietary supplements for adults.
33065525	7	55	with	hour	1136:1139	arg1	gel					1174:1176	the borate-buffered dextran gel	1146:1176	the borate-buffered dextran gel	1146:1176	Considering the rapid analysis time and multiplexing (12-channel system), a 96 well sample plate can be analyzed in less than 80 min with the conventional type carbohydrate separation matrix and in less than one hour with the borate-buffered dextran gel.
33065525	0	56	theme	gel	84:86	arg1	electrophoresis					88:102	multicapillary gel electrophoresis	69:102	multicapillary gel electrophoresis	69:102	Ultrafast high-resolution analysis of human milk oligosaccharides by multicapillary gel electrophoresis.
33065525	6	57	theme	diol	883:886	arg1	complexation					888:899	the borate-vicinal diol complexation	864:899	the borate-vicinal diol complexation	864:899	The other one was a borate-buffered dextran gel, which utilized the secondary equilibrium of the borate-vicinal diol complexation to enhance resolution.
33065525	1	58	theme	milk	166:169	arg1	oligosaccharides					171:186	synthesized human milk oligosaccharides	148:186	synthesized human milk oligosaccharides (HMOs) as baby formula additives	148:219	There is recently growing interest towards synthesized human milk oligosaccharides (HMOs) as baby formula additives, and interestingly also as dietary supplements for adults.
33065525	1	58	theme	milk	166:169	arg1	HMOs					189:192	HMOs	189:192	HMOs	189:192	There is recently growing interest towards synthesized human milk oligosaccharides (HMOs) as baby formula additives, and interestingly also as dietary supplements for adults.
33065525	9	59	theme	HMOs	1469:1472	arg1	quantities					1429:1438	the quantities	1425:1438	the quantities of several low concentration HMOs	1425:1472	Based on the calibration plot, the quantities of several low concentration HMOs were determined from a human milk sample.
33065525	1	60	theme	dietary	248:254	arg1	supplements					256:266	dietary supplements	248:266	dietary supplements for adults	248:277	There is recently growing interest towards synthesized human milk oligosaccharides (HMOs) as baby formula additives, and interestingly also as dietary supplements for adults.
33065525	0	61	theme	multicapillary	69:82	arg1	electrophoresis					88:102	multicapillary gel electrophoresis	69:102	multicapillary gel electrophoresis	69:102	Ultrafast high-resolution analysis of human milk oligosaccharides by multicapillary gel electrophoresis.
33422299	0	0	theme	Streptococcus	81:93	arg1	virulence					102:110	the Streptococcus mutans virulence	77:110	the Streptococcus mutans virulence	77:110	Incorporation of Apigenin and tt-Farnesol into dental composites to modulate the Streptococcus mutans virulence.
33422299	1	1	theme	study	149:153	arg1	aim					128:130	The aim	124:130	The aim of this in vitro study	124:153	OBJECTIVES The aim of this in vitro study was to incorporate two anti-caries agents, Apigenin and tt-Farnesol, to resin composite and resin cement to reduce the virulence of Streptococcus mutans around dental restorations.
33422299	3	2	dep	polysaccharides	553:567	arg1	water-soluble					604:616	water-soluble	604:616	water-soluble	604:616	Biofilm of S. mutans was grown on composite discs, and the dry-weight, bacterial viability, and the polysaccharides (alkali-soluble, intracellular and water-soluble) were quantified.
33422299	3	2	dep	polysaccharides	553:567	arg1	intracellular					586:598	intracellular	586:598	intracellular	586:598	Biofilm of S. mutans was grown on composite discs, and the dry-weight, bacterial viability, and the polysaccharides (alkali-soluble, intracellular and water-soluble) were quantified.
33422299	3	2	dep	polysaccharides	553:567	arg1	alkali-soluble					570:583	alkali-soluble	570:583	alkali-soluble	570:583	Biofilm of S. mutans was grown on composite discs, and the dry-weight, bacterial viability, and the polysaccharides (alkali-soluble, intracellular and water-soluble) were quantified.
33422299	10	3	theme	water-soluble	1359:1371	arg1	polysaccharides					1373:1387	the water-soluble polysaccharides	1355:1387	the water-soluble polysaccharides	1355:1387	No difference was observed for the water-soluble polysaccharides, flexural strength, and elastic modulus.
33422299	5	4	theme	colorimetric	803:814	arg1	parameters					816:825	the composite colorimetric parameters	789:825	the composite colorimetric parameters	789:825	The effect of the additions on the physicochemical properties and the composite colorimetric parameters were also analyzed.
33422299	9	5	theme	Statistical	1163:1173	arg1	difference					1175:1184	Statistical difference	1163:1184	Statistical difference	1163:1184	Statistical difference was obtained for the degree of conversion; however, the maximum polymerization rate and curing kinetics were unaffected by the additions.
33422299	9	6	theme	conversion	1217:1226	arg1	degree					1207:1212	the degree	1203:1212	the degree of conversion	1203:1226	Statistical difference was obtained for the degree of conversion; however, the maximum polymerization rate and curing kinetics were unaffected by the additions.
33422299	7	7	theme	intracellular	1019:1031	arg1	polysaccharides					1033:1047	the bacterial dry-weight, alkali-soluble and intracellular polysaccharides	974:1047	the bacterial dry-weight, alkali-soluble and intracellular polysaccharides	974:1047	Api alone and combined with Far or combined with Far and F decreased the bacterial dry-weight, alkali-soluble and intracellular polysaccharides.
33422299	4	8	theme	biofilm	665:671	arg1	images					641:646	CLSM images	636:646	CLSM images of the S. mutans biofilm	636:671	CLSM images of the S. mutans biofilm were obtained after three years of water-storage.
33422299	12	9	theme	composites	1624:1633	arg1	properties					1606:1615	the physicochemical properties	1586:1615	the physicochemical properties of the composites	1586:1633	SIGNIFICANCE Api, alone and combined, reduced the expression of virulence of S. mutans without jeopardizing the physicochemical properties of the composites.
33422299	1	10	theme	resin	247:251	arg1	cement					253:258	resin cement	247:258	resin cement	247:258	OBJECTIVES The aim of this in vitro study was to incorporate two anti-caries agents, Apigenin and tt-Farnesol, to resin composite and resin cement to reduce the virulence of Streptococcus mutans around dental restorations.
33422299	4	11	theme	mutans	658:663	arg1	biofilm					665:671	the S. mutans biofilm	651:671	the S. mutans biofilm	651:671	CLSM images of the S. mutans biofilm were obtained after three years of water-storage.
33422299	2	12	dep	Apigenin	344:351	arg1	Api					354:356	Api	354:356	Api	354:356	METHODS Apigenin (Api, 5 mM) and tt-Farnesol (Far, 5 mM) were added alone, together, and combined with fluoride (F).
33422299	2	12	dep	Apigenin	344:351	arg1	mM					361:362	5 mM	359:362	5 mM	359:362	METHODS Apigenin (Api, 5 mM) and tt-Farnesol (Far, 5 mM) were added alone, together, and combined with fluoride (F).
33422299	5	13	from	effect	727:732	arg1	parameters					816:825	the composite colorimetric parameters	789:825	the composite colorimetric parameters	789:825	The effect of the additions on the physicochemical properties and the composite colorimetric parameters were also analyzed.
33422299	5	13	from	effect	727:732	arg1	properties					774:783	the physicochemical properties	754:783	the physicochemical properties	754:783	The effect of the additions on the physicochemical properties and the composite colorimetric parameters were also analyzed.
33422299	2	14	dep	mM	389:390	arg1	Far					382:384	Far	382:384	Far	382:384	METHODS Apigenin (Api, 5 mM) and tt-Farnesol (Far, 5 mM) were added alone, together, and combined with fluoride (F).
33422299	8	15	theme	biofilm	1154:1160	arg1	top					1147:1149	the top	1143:1149	the top of biofilm	1143:1160	After three years, the composites containing the additions presented a greater EPS matrix on the top of biofilm.
33422299	10	16	theme	flexural	1390:1397	arg1	strength					1399:1406	flexural strength	1390:1406	flexural strength	1390:1406	No difference was observed for the water-soluble polysaccharides, flexural strength, and elastic modulus.
33422299	8	17	contain	containing	1084:1093	arg2	additions					1099:1107	the additions	1095:1107	the additions	1095:1107	After three years, the composites containing the additions presented a greater EPS matrix on the top of biofilm.
33422299	8	17	contain	containing	1084:1093	arg1	composites					1073:1082	the composites	1069:1082	the composites containing the additions	1069:1107	After three years, the composites containing the additions presented a greater EPS matrix on the top of biofilm.
33422299	5	18	theme	physicochemical	758:772	arg1	properties					774:783	the physicochemical properties	754:783	the physicochemical properties	754:783	The effect of the additions on the physicochemical properties and the composite colorimetric parameters were also analyzed.
33422299	7	19	theme	dry-weight	988:997	arg1	polysaccharides					1033:1047	the bacterial dry-weight, alkali-soluble and intracellular polysaccharides	974:1047	the bacterial dry-weight, alkali-soluble and intracellular polysaccharides	974:1047	Api alone and combined with Far or combined with Far and F decreased the bacterial dry-weight, alkali-soluble and intracellular polysaccharides.
33422299	0	20	dep	Streptococcus	81:93	arg1	mutans					95:100	mutans	95:100	mutans	95:100	Incorporation of Apigenin and tt-Farnesol into dental composites to modulate the Streptococcus mutans virulence.
33422299	12	21	theme	physicochemical	1590:1604	arg1	properties					1606:1615	the physicochemical properties	1586:1615	the physicochemical properties of the composites	1586:1633	SIGNIFICANCE Api, alone and combined, reduced the expression of virulence of S. mutans without jeopardizing the physicochemical properties of the composites.
33422299	9	22	theme	maximum	1242:1248	arg1	rate					1265:1268	the maximum polymerization rate	1238:1268	the maximum polymerization rate	1238:1268	Statistical difference was obtained for the degree of conversion; however, the maximum polymerization rate and curing kinetics were unaffected by the additions.
33422299	7	23	theme	alkali-soluble	1000:1013	arg1	polysaccharides					1033:1047	the bacterial dry-weight, alkali-soluble and intracellular polysaccharides	974:1047	the bacterial dry-weight, alkali-soluble and intracellular polysaccharides	974:1047	Api alone and combined with Far or combined with Far and F decreased the bacterial dry-weight, alkali-soluble and intracellular polysaccharides.
33422299	1	24	theme	anti-caries	178:188	arg1	tt-Farnesol					211:221	tt-Farnesol	211:221	tt-Farnesol	211:221	OBJECTIVES The aim of this in vitro study was to incorporate two anti-caries agents, Apigenin and tt-Farnesol, to resin composite and resin cement to reduce the virulence of Streptococcus mutans around dental restorations.
33422299	1	24	theme	anti-caries	178:188	arg1	Apigenin					198:205	Apigenin	198:205	Apigenin	198:205	OBJECTIVES The aim of this in vitro study was to incorporate two anti-caries agents, Apigenin and tt-Farnesol, to resin composite and resin cement to reduce the virulence of Streptococcus mutans around dental restorations.
33422299	1	24	theme	anti-caries	178:188	arg1	agents					190:195	two anti-caries agents	174:195	two anti-caries agents	174:195	OBJECTIVES The aim of this in vitro study was to incorporate two anti-caries agents, Apigenin and tt-Farnesol, to resin composite and resin cement to reduce the virulence of Streptococcus mutans around dental restorations.
33422299	8	25	theme	EPS	1129:1131	arg1	matrix					1133:1138	a greater EPS matrix	1119:1138	a greater EPS matrix	1119:1138	After three years, the composites containing the additions presented a greater EPS matrix on the top of biofilm.
33422299	6	26	theme	bacterial	884:892	arg1	viability					894:902	bacterial viability	884:902	bacterial viability	884:902	RESULTS The additions did not affect bacterial viability.
33422299	2	27	dep	METHODS	336:342	arg1	METHODS					336:342	METHODS Apigenin (Api, 5 mM) and tt-Farnesol (Far, 5 mM)	336:391	METHODS Apigenin (Api, 5 mM) and tt-Farnesol (Far, 5 mM)	336:391	METHODS Apigenin (Api, 5 mM) and tt-Farnesol (Far, 5 mM) were added alone, together, and combined with fluoride (F).
33422299	2	27	dep	METHODS	336:342	arg1	tt-Farnesol					369:379	tt-Farnesol	369:379	tt-Farnesol (Far, 5 mM)	369:391	METHODS Apigenin (Api, 5 mM) and tt-Farnesol (Far, 5 mM) were added alone, together, and combined with fluoride (F).
33422299	2	27	dep	METHODS	336:342	arg1	Apigenin					344:351	Apigenin	344:351	Apigenin (Api, 5 mM)	344:363	METHODS Apigenin (Api, 5 mM) and tt-Farnesol (Far, 5 mM) were added alone, together, and combined with fluoride (F).
33422299	11	28	theme	composites	1466:1475	arg1	yellowness					1448:1457	the yellowness	1444:1457	the yellowness of the composites	1444:1475	Api increased the yellowness of the composites.
33422299	0	29	theme	Apigenin	17:24	arg1	Incorporation					0:12	Incorporation	0:12	Incorporation of Apigenin and tt-Farnesol into dental composites	0:63	Incorporation of Apigenin and tt-Farnesol into dental composites to modulate the Streptococcus mutans virulence.
33422299	12	30	theme	virulence	1542:1550	arg1	expression					1528:1537	the expression	1524:1537	the expression of virulence of S. mutans	1524:1563	SIGNIFICANCE Api, alone and combined, reduced the expression of virulence of S. mutans without jeopardizing the physicochemical properties of the composites.
33422299	7	31	theme	bacterial	978:986	arg1	polysaccharides					1033:1047	the bacterial dry-weight, alkali-soluble and intracellular polysaccharides	974:1047	the bacterial dry-weight, alkali-soluble and intracellular polysaccharides	974:1047	Api alone and combined with Far or combined with Far and F decreased the bacterial dry-weight, alkali-soluble and intracellular polysaccharides.
33422299	1	32	dep	in	140:141	arg1	vitro					143:147	vitro	143:147	vitro	143:147	OBJECTIVES The aim of this in vitro study was to incorporate two anti-caries agents, Apigenin and tt-Farnesol, to resin composite and resin cement to reduce the virulence of Streptococcus mutans around dental restorations.
33422299	10	33	theme	elastic	1413:1419	arg1	modulus					1421:1427	elastic modulus	1413:1427	elastic modulus	1413:1427	No difference was observed for the water-soluble polysaccharides, flexural strength, and elastic modulus.
33422299	6	34	dep	RESULTS	847:853	arg1	additions					859:867	The additions	855:867	RESULTS The additions	847:867	RESULTS The additions did not affect bacterial viability.
33422299	8	35	attach	presented	1109:1117	arg2	composites					1073:1082	the composites	1069:1082	the composites containing the additions	1069:1107	After three years, the composites containing the additions presented a greater EPS matrix on the top of biofilm.
33422299	8	35	attach	presented	1109:1117	arg1	top					1147:1149	the top	1143:1149	the top of biofilm	1143:1160	After three years, the composites containing the additions presented a greater EPS matrix on the top of biofilm.
33422299	12	36	theme	mutans	1558:1563	arg1	virulence					1542:1550	virulence	1542:1550	virulence of S. mutans	1542:1563	SIGNIFICANCE Api, alone and combined, reduced the expression of virulence of S. mutans without jeopardizing the physicochemical properties of the composites.
33422299	5	37	theme	additions	741:749	arg1	effect					727:732	The effect	723:732	The effect of the additions on the physicochemical properties and the composite colorimetric parameters	723:825	The effect of the additions on the physicochemical properties and the composite colorimetric parameters were also analyzed.
33422299	0	38	theme	tt-Farnesol	30:40	arg1	Incorporation					0:12	Incorporation	0:12	Incorporation of Apigenin and tt-Farnesol into dental composites	0:63	Incorporation of Apigenin and tt-Farnesol into dental composites to modulate the Streptococcus mutans virulence.
33422299	9	39	theme	curing	1274:1279	arg1	kinetics					1281:1288	curing kinetics	1274:1288	curing kinetics	1274:1288	Statistical difference was obtained for the degree of conversion; however, the maximum polymerization rate and curing kinetics were unaffected by the additions.
33422299	2	40	dep	tt-Farnesol	369:379	arg1	mM					389:390	5 mM	387:390	5 mM	387:390	METHODS Apigenin (Api, 5 mM) and tt-Farnesol (Far, 5 mM) were added alone, together, and combined with fluoride (F).
33422299	4	41	theme	S.	655:656	arg1	biofilm					665:671	the S. mutans biofilm	651:671	the S. mutans biofilm	651:671	CLSM images of the S. mutans biofilm were obtained after three years of water-storage.
33422299	1	42	theme	Streptococcus	287:299	arg1	mutans					301:306	Streptococcus mutans	287:306	Streptococcus mutans	287:306	OBJECTIVES The aim of this in vitro study was to incorporate two anti-caries agents, Apigenin and tt-Farnesol, to resin composite and resin cement to reduce the virulence of Streptococcus mutans around dental restorations.
33422299	9	43	theme	polymerization	1250:1263	arg1	rate					1265:1268	the maximum polymerization rate	1238:1268	the maximum polymerization rate	1238:1268	Statistical difference was obtained for the degree of conversion; however, the maximum polymerization rate and curing kinetics were unaffected by the additions.
33422299	3	44	theme	composite	487:495	arg1	discs					497:501	composite discs	487:501	composite discs	487:501	Biofilm of S. mutans was grown on composite discs, and the dry-weight, bacterial viability, and the polysaccharides (alkali-soluble, intracellular and water-soluble) were quantified.
33422299	0	45	theme	dental	47:52	arg1	composites					54:63	dental composites	47:63	dental composites	47:63	Incorporation of Apigenin and tt-Farnesol into dental composites to modulate the Streptococcus mutans virulence.
33422299	1	46	theme	mutans	301:306	arg1	virulence					274:282	the virulence	270:282	the virulence of Streptococcus mutans around dental restorations	270:333	OBJECTIVES The aim of this in vitro study was to incorporate two anti-caries agents, Apigenin and tt-Farnesol, to resin composite and resin cement to reduce the virulence of Streptococcus mutans around dental restorations.
33422299	4	47	theme	water-storage	708:720	arg1	years					699:703	three years	693:703	three years of water-storage	693:720	CLSM images of the S. mutans biofilm were obtained after three years of water-storage.
33422299	4	48	theme	CLSM	636:639	arg1	images					641:646	CLSM images	636:646	CLSM images of the S. mutans biofilm	636:671	CLSM images of the S. mutans biofilm were obtained after three years of water-storage.
33422299	3	49	theme	mutans	467:472	arg1	Biofilm					453:459	Biofilm	453:459	Biofilm of S. mutans	453:472	Biofilm of S. mutans was grown on composite discs, and the dry-weight, bacterial viability, and the polysaccharides (alkali-soluble, intracellular and water-soluble) were quantified.
33422299	3	50	theme	bacterial	524:532	arg1	viability					534:542	bacterial viability	524:542	bacterial viability	524:542	Biofilm of S. mutans was grown on composite discs, and the dry-weight, bacterial viability, and the polysaccharides (alkali-soluble, intracellular and water-soluble) were quantified.
33422299	5	51	theme	composite	793:801	arg1	parameters					816:825	the composite colorimetric parameters	789:825	the composite colorimetric parameters	789:825	The effect of the additions on the physicochemical properties and the composite colorimetric parameters were also analyzed.
33422299	12	52	theme	SIGNIFICANCE	1478:1489	arg1	Api					1491:1493	SIGNIFICANCE Api	1478:1493	SIGNIFICANCE Api	1478:1493	SIGNIFICANCE Api, alone and combined, reduced the expression of virulence of S. mutans without jeopardizing the physicochemical properties of the composites.
33422299	1	53	theme	in	140:141	arg1	study					149:153	this in vitro study	135:153	this in vitro study	135:153	OBJECTIVES The aim of this in vitro study was to incorporate two anti-caries agents, Apigenin and tt-Farnesol, to resin composite and resin cement to reduce the virulence of Streptococcus mutans around dental restorations.
33422299	1	54	theme	dental	315:320	arg1	restorations					322:333	dental restorations	315:333	dental restorations	315:333	OBJECTIVES The aim of this in vitro study was to incorporate two anti-caries agents, Apigenin and tt-Farnesol, to resin composite and resin cement to reduce the virulence of Streptococcus mutans around dental restorations.
33422299	8	55	theme	greater	1121:1127	arg1	matrix					1133:1138	a greater EPS matrix	1119:1138	a greater EPS matrix	1119:1138	After three years, the composites containing the additions presented a greater EPS matrix on the top of biofilm.
33422299	1	56	dep	OBJECTIVES	113:122	arg1	was					155:157	was	155:157	was to incorporate two anti-caries agents, Apigenin and tt-Farnesol, to resin composite and resin cement to reduce the virulence of Streptococcus mutans around dental restorations	155:333	OBJECTIVES The aim of this in vitro study was to incorporate two anti-caries agents, Apigenin and tt-Farnesol, to resin composite and resin cement to reduce the virulence of Streptococcus mutans around dental restorations.
33422299	1	57	theme	resin	227:231	arg1	composite					233:241	resin composite	227:241	resin composite	227:241	OBJECTIVES The aim of this in vitro study was to incorporate two anti-caries agents, Apigenin and tt-Farnesol, to resin composite and resin cement to reduce the virulence of Streptococcus mutans around dental restorations.
34342829	9	0	from	water	1829:1833	arg1	determination					1778:1790	the determination	1774:1790	the determination of Pb(II) ions in spring water, well water, river water and tap water samples	1774:1868	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	6	1	from	series	1173:1178	arg1	solution					1203:1210	a solution	1201:1210	a solution containing 2 μM Pb(II)	1201:1233	The reproducibility of the proposed method, based on a series of 8 measurements in a solution containing 2 μM Pb(II) gave a coefficient of variation of 1.27%.
34342829	7	2	from	curve	1397:1401	arg1	range					1433:1437	the concentration range	1415:1437	the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998)	1415:1490	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	8	3	theme	proposed	1547:1554	arg1	sensor					1556:1561	the proposed sensor	1543:1561	the proposed sensor	1543:1561	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	1	4	theme	natural	259:265	arg1	hydroxyapatite					267:280	natural hydroxyapatite	259:280	natural hydroxyapatite using citric acid as cross linker	259:314	A composite material prepared by polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).
34342829	1	5	theme	composite	170:178	arg1	material					180:187	A composite material	168:187	A composite material	168:187	A composite material prepared by polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).
34342829	1	5	theme	composite	170:178	arg1	material					343:350	electrode material	333:350	electrode material for the detection of Pb(II)	333:378	A composite material prepared by polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).
34342829	4	6	theme	exchange	779:786	arg1	ability					788:794	the ion exchange ability	771:794	the ion exchange ability of NHAPp0.5-CA-β-CD	771:814	Upon deposition as thin film on a glassy carbon electrode (GCE), the ion exchange ability of NHAPp0.5-CA-β-CD was exploited to elaborate a sensitive sensor for the detection of lead.
34342829	0	7	theme	electrochemical	131:145	arg1	detection					147:155	the electrochemical detection	127:155	the electrochemical detection of Pb(II)	127:165	Surface functionalization of natural hydroxyapatite by polymerization of β-cyclodextrin: application as electrode material for the electrochemical detection of Pb(II).
34342829	5	8	theme	open-circuit	981:992	arg1	conditions					994:1003	open-circuit conditions	981:1003	open-circuit conditions	981:1003	The electroanalytical procedure was based on the chemical accumulation of Pb(II) ions under open-circuit conditions, followed by the detection of the preconcentrated species using differential pulse anodic stripping voltammetry.
34342829	7	9	theme	mol	1471:1473	arg1	L-1					1475:1477	2 × 10-8 mol L-1 - 20 × 10-8 mol L-1	1442:1477	2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998)	1442:1490	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	5	10	dep	based	925:929	arg1	followed					1006:1013	followed	1006:1013	followed by the detection of the preconcentrated species using differential pulse anodic stripping voltammetry	1006:1115	The electroanalytical procedure was based on the chemical accumulation of Pb(II) ions under open-circuit conditions, followed by the detection of the preconcentrated species using differential pulse anodic stripping voltammetry.
34342829	1	11	from	surface	248:254	arg1	polymerization					201:214	polymerization	201:214	polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker	201:314	A composite material prepared by polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).
34342829	8	12	theme	sensor	1556:1561	arg1	sensitivity					1528:1538	the sensitivity	1524:1538	the sensitivity of the proposed sensor	1524:1561	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	8	12	theme	sensor	1556:1561	arg1	3S/m					1514:1517	3S/m	1514:1517	3S/m	1514:1517	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	8	12	theme	sensor	1556:1561	arg1	×					1573:1573	5.06 ×	1568:1573	5.06 × 10-10 mol L-1 and 100.80 μA.μM-1	1568:1606	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	8	12	theme	sensor	1556:1561	arg1	limit					1507:1511	The detection limit	1493:1511	The detection limit (3S/m)	1493:1518	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	1	13	theme	β-cyclodextrin	219:232	arg1	polymerization					201:214	polymerization	201:214	polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker	201:314	A composite material prepared by polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).
34342829	7	14	theme	×	1464:1464	arg1	L-1					1475:1477	2 × 10-8 mol L-1 - 20 × 10-8 mol L-1	1442:1477	2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998)	1442:1490	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	6	15	theme	method	1154:1159	arg1	reproducibility					1122:1136	The reproducibility	1118:1136	The reproducibility of the proposed method, based on a series of 8 measurements in a solution containing 2 μM Pb(II)	1118:1233	The reproducibility of the proposed method, based on a series of 8 measurements in a solution containing 2 μM Pb(II) gave a coefficient of variation of 1.27%.
34342829	5	16	theme	ions	970:973	arg1	accumulation					947:958	the chemical accumulation	934:958	the chemical accumulation of Pb(II) ions under open-circuit conditions	934:1003	The electroanalytical procedure was based on the chemical accumulation of Pb(II) ions under open-circuit conditions, followed by the detection of the preconcentrated species using differential pulse anodic stripping voltammetry.
34342829	8	17	theme	10-10	1575:1579	arg1	mol					1581:1583	mol	1581:1583	mol	1581:1583	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	7	18	theme	mol	1451:1453	arg1	L-1					1475:1477	2 × 10-8 mol L-1 - 20 × 10-8 mol L-1	1442:1477	2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998)	1442:1490	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	0	19	theme	β-cyclodextrin	73:86	arg1	polymerization					55:68	polymerization	55:68	polymerization of β-cyclodextrin	55:86	Surface functionalization of natural hydroxyapatite by polymerization of β-cyclodextrin: application as electrode material for the electrochemical detection of Pb(II).
34342829	3	20	theme	pristine	577:584	arg1	NHAPP0.5					602:609	NHAPP0.5	602:609	NHAPP0.5	602:609	The structure and morphology of the pristine hydroxyapatite (NHAPP0.5) and its functionalized counterpart (NHAPp0.5-CA-β-CD) were examined using XRD, FTIR, and SEM.
34342829	3	20	theme	pristine	577:584	arg1	hydroxyapatite					586:599	the pristine hydroxyapatite	573:599	the pristine hydroxyapatite (NHAPP0.5)	573:610	The structure and morphology of the pristine hydroxyapatite (NHAPP0.5) and its functionalized counterpart (NHAPp0.5-CA-β-CD) were examined using XRD, FTIR, and SEM.
34342829	7	21	theme	×	1444:1444	arg1	L-1					1475:1477	2 × 10-8 mol L-1 - 20 × 10-8 mol L-1	1442:1477	2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998)	1442:1490	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	6	22	theme	1.27	1270:1273	arg1	%					1274:1274	1.27%	1270:1274	1.27%	1270:1274	The reproducibility of the proposed method, based on a series of 8 measurements in a solution containing 2 μM Pb(II) gave a coefficient of variation of 1.27%.
34342829	5	23	theme	species	1055:1061	arg1	detection					1022:1030	the detection	1018:1030	the detection of the preconcentrated species using differential pulse anodic stripping voltammetry	1018:1115	The electroanalytical procedure was based on the chemical accumulation of Pb(II) ions under open-circuit conditions, followed by the detection of the preconcentrated species using differential pulse anodic stripping voltammetry.
34342829	4	24	from	film	730:733	arg1	GCE					765:767	GCE	765:767	GCE	765:767	Upon deposition as thin film on a glassy carbon electrode (GCE), the ion exchange ability of NHAPp0.5-CA-β-CD was exploited to elaborate a sensitive sensor for the detection of lead.
34342829	4	24	from	film	730:733	arg1	electrode					754:762	a glassy carbon electrode	738:762	a glassy carbon electrode (GCE)	738:768	Upon deposition as thin film on a glassy carbon electrode (GCE), the ion exchange ability of NHAPp0.5-CA-β-CD was exploited to elaborate a sensitive sensor for the detection of lead.
34342829	9	25	theme	Pb	1795:1796	arg1	ions					1802:1805	Pb(II) ions	1795:1805	Pb(II) ions in spring water, well water, river water and tap water samples	1795:1868	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	0	26	theme	electrode	104:112	arg1	material					114:121	electrode material	104:121	electrode material	104:121	Surface functionalization of natural hydroxyapatite by polymerization of β-cyclodextrin: application as electrode material for the electrochemical detection of Pb(II).
34342829	5	27	theme	electroanalytical	893:909	arg1	procedure					911:919	The electroanalytical procedure	889:919	The electroanalytical procedure	889:919	The electroanalytical procedure was based on the chemical accumulation of Pb(II) ions under open-circuit conditions, followed by the detection of the preconcentrated species using differential pulse anodic stripping voltammetry.
34342829	7	28	theme	concentration	1419:1431	arg1	range					1433:1437	the concentration range	1415:1437	the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998)	1415:1490	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	9	29	theme	II	1798:1799	arg1	ions					1802:1805	Pb(II) ions	1795:1805	Pb(II) ions in spring water, well water, river water and tap water samples	1795:1868	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	2	30	with	treatment	497:505	arg1	2HPO4					517:521	(NH4)2HPO4	512:521	(NH4)2HPO4	512:521	Hydroxyapatite was obtained from bovine bones, following a three-step procedure including pre-calcination, chemical treatment with (NH4)2HPO4, and calcination.
34342829	9	31	from	determination	1778:1790	arg1	water					1817:1821	spring water	1810:1821	spring water	1810:1821	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	9	31	from	determination	1778:1790	arg1	water					1829:1833	well water	1824:1833	well water	1824:1833	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	9	31	from	determination	1778:1790	arg1	water					1842:1846	river water	1836:1846	river water	1836:1846	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	9	31	from	determination	1778:1790	arg1	water					1856:1860	tap water	1852:1860	tap water	1852:1860	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	9	32	theme	ions	1802:1805	arg1	determination					1778:1790	the determination	1774:1790	the determination of Pb(II) ions in spring water, well water, river water and tap water samples	1774:1868	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	0	33	theme	Surface	0:6	arg1	functionalization					8:24	Surface functionalization	0:24	Surface functionalization of natural hydroxyapatite by polymerization of β-cyclodextrin: application as electrode material for the electrochemical detection of Pb(II).	0:166	Surface functionalization of natural hydroxyapatite by polymerization of β-cyclodextrin: application as electrode material for the electrochemical detection of Pb(II).
34342829	1	34	theme	hydroxyapatite	267:280	arg1	surface					248:254	the surface	244:254	the surface of natural hydroxyapatite using citric acid as cross linker	244:314	A composite material prepared by polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).
34342829	9	35	theme	spring	1810:1815	arg1	water					1817:1821	spring water	1810:1821	spring water	1810:1821	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	1	36	theme	citric	288:293	arg1	acid					295:298	citric acid	288:298	citric acid	288:298	A composite material prepared by polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).
34342829	2	37	theme	three-step	440:449	arg1	procedure					451:459	a three-step procedure	438:459	a three-step procedure including pre-calcination, chemical treatment with (NH4)2HPO4, and calcination	438:538	Hydroxyapatite was obtained from bovine bones, following a three-step procedure including pre-calcination, chemical treatment with (NH4)2HPO4, and calcination.
34342829	0	38	theme	hydroxyapatite	37:50	arg1	functionalization					8:24	Surface functionalization	0:24	Surface functionalization of natural hydroxyapatite by polymerization of β-cyclodextrin: application as electrode material for the electrochemical detection of Pb(II).	0:166	Surface functionalization of natural hydroxyapatite by polymerization of β-cyclodextrin: application as electrode material for the electrochemical detection of Pb(II).
34342829	5	39	theme	differential	1069:1080	arg1	voltammetry					1105:1115	differential pulse anodic stripping voltammetry	1069:1115	differential pulse anodic stripping voltammetry	1069:1115	The electroanalytical procedure was based on the chemical accumulation of Pb(II) ions under open-circuit conditions, followed by the detection of the preconcentrated species using differential pulse anodic stripping voltammetry.
34342829	9	40	from	water	1856:1860	arg1	determination					1778:1790	the determination	1774:1790	the determination of Pb(II) ions in spring water, well water, river water and tap water samples	1774:1868	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	5	41	theme	anodic	1088:1093	arg1	voltammetry					1105:1115	differential pulse anodic stripping voltammetry	1069:1115	differential pulse anodic stripping voltammetry	1069:1115	The electroanalytical procedure was based on the chemical accumulation of Pb(II) ions under open-circuit conditions, followed by the detection of the preconcentrated species using differential pulse anodic stripping voltammetry.
34342829	7	42	theme	linear	1378:1383	arg1	curve					1397:1401	a linear calibration curve	1376:1401	a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998)	1376:1490	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	9	43	theme	river	1836:1840	arg1	water					1842:1846	river water	1836:1846	river water	1836:1846	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	9	44	from	ions	1802:1805	arg1	water					1817:1821	spring water	1810:1821	spring water	1810:1821	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	9	44	from	ions	1802:1805	arg1	water					1829:1833	well water	1824:1833	well water	1824:1833	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	9	44	from	ions	1802:1805	arg1	water					1842:1846	river water	1836:1846	river water	1836:1846	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	9	44	from	ions	1802:1805	arg1	water					1856:1860	tap water	1852:1860	tap water	1852:1860	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	9	45	theme	several	1649:1655	arg1	ions					1657:1660	several ions	1649:1660	several ions expected to affect the determination of lead	1649:1705	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	3	46	theme	counterpart	635:645	arg1	morphology					559:568	morphology	559:568	morphology	559:568	The structure and morphology of the pristine hydroxyapatite (NHAPP0.5) and its functionalized counterpart (NHAPp0.5-CA-β-CD) were examined using XRD, FTIR, and SEM.
34342829	3	46	theme	counterpart	635:645	arg1	structure					545:553	structure	545:553	structure	545:553	The structure and morphology of the pristine hydroxyapatite (NHAPP0.5) and its functionalized counterpart (NHAPp0.5-CA-β-CD) were examined using XRD, FTIR, and SEM.
34342829	4	47	theme	carbon	747:752	arg1	GCE					765:767	GCE	765:767	GCE	765:767	Upon deposition as thin film on a glassy carbon electrode (GCE), the ion exchange ability of NHAPp0.5-CA-β-CD was exploited to elaborate a sensitive sensor for the detection of lead.
34342829	4	47	theme	carbon	747:752	arg1	electrode					754:762	a glassy carbon electrode	738:762	a glassy carbon electrode (GCE)	738:768	Upon deposition as thin film on a glassy carbon electrode (GCE), the ion exchange ability of NHAPp0.5-CA-β-CD was exploited to elaborate a sensitive sensor for the detection of lead.
34342829	5	48	theme	chemical	938:945	arg1	accumulation					947:958	the chemical accumulation	934:958	the chemical accumulation of Pb(II) ions under open-circuit conditions	934:1003	The electroanalytical procedure was based on the chemical accumulation of Pb(II) ions under open-circuit conditions, followed by the detection of the preconcentrated species using differential pulse anodic stripping voltammetry.
34342829	5	49	theme	pulse	1082:1086	arg1	voltammetry					1105:1115	differential pulse anodic stripping voltammetry	1069:1115	differential pulse anodic stripping voltammetry	1069:1115	The electroanalytical procedure was based on the chemical accumulation of Pb(II) ions under open-circuit conditions, followed by the detection of the preconcentrated species using differential pulse anodic stripping voltammetry.
34342829	8	50	theme	detection	1497:1505	arg1	3S/m					1514:1517	3S/m	1514:1517	3S/m	1514:1517	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	8	50	theme	detection	1497:1505	arg1	×					1573:1573	5.06 ×	1568:1573	5.06 × 10-10 mol L-1 and 100.80 μA.μM-1	1568:1606	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	8	50	theme	detection	1497:1505	arg1	limit					1507:1511	The detection limit	1493:1511	The detection limit (3S/m)	1493:1518	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	6	51	from	measurements	1185:1196	arg1	solution					1203:1210	a solution	1201:1210	a solution containing 2 μM Pb(II)	1201:1233	The reproducibility of the proposed method, based on a series of 8 measurements in a solution containing 2 μM Pb(II) gave a coefficient of variation of 1.27%.
34342829	4	52	theme	NHAPp0.5-CA-β-CD	799:814	arg1	ability					788:794	the ion exchange ability	771:794	the ion exchange ability of NHAPp0.5-CA-β-CD	771:814	Upon deposition as thin film on a glassy carbon electrode (GCE), the ion exchange ability of NHAPp0.5-CA-β-CD was exploited to elaborate a sensitive sensor for the detection of lead.
34342829	6	53	theme	measurements	1185:1196	arg1	series					1173:1178	a series	1171:1178	a series of 8 measurements in a solution containing 2 μM Pb(II)	1171:1233	The reproducibility of the proposed method, based on a series of 8 measurements in a solution containing 2 μM Pb(II) gave a coefficient of variation of 1.27%.
34342829	3	54	dep	structure	545:553	arg1	The					541:543	The	541:543	The	541:543	The structure and morphology of the pristine hydroxyapatite (NHAPP0.5) and its functionalized counterpart (NHAPp0.5-CA-β-CD) were examined using XRD, FTIR, and SEM.
34342829	7	55	theme	Pb	1342:1343	arg1	response					1330:1337	the stripping response	1316:1337	the stripping response of Pb(II)	1316:1347	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	7	56	theme	stripping	1320:1328	arg1	response					1330:1337	the stripping response	1316:1337	the stripping response of Pb(II)	1316:1347	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	9	57	theme	lead	1702:1705	arg1	determination					1685:1697	the determination	1681:1697	the determination of lead	1681:1705	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	7	58	dep	L-1	1475:1477	arg1	=					1483:1483	=	1483:1483	=	1483:1483	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	7	59	theme	L-1	1475:1477	arg1	range					1433:1437	the concentration range	1415:1437	the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998)	1415:1490	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	4	60	theme	ion	775:777	arg1	ability					788:794	the ion exchange ability	771:794	the ion exchange ability of NHAPp0.5-CA-β-CD	771:814	Upon deposition as thin film on a glassy carbon electrode (GCE), the ion exchange ability of NHAPp0.5-CA-β-CD was exploited to elaborate a sensitive sensor for the detection of lead.
34342829	8	61	theme	100.80	1593:1598	arg1	μA.μM-1					1600:1606	100.80 μA.μM-1	1593:1606	100.80 μA.μM-1	1593:1606	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	8	61	theme	100.80	1593:1598	arg1	×					1573:1573	5.06 ×	1568:1573	5.06 × 10-10 mol L-1 and 100.80 μA.μM-1	1568:1606	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	7	62	theme	10-8	1466:1469	arg1	L-1					1475:1477	2 × 10-8 mol L-1 - 20 × 10-8 mol L-1	1442:1477	2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998)	1442:1490	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	4	63	theme	sensitive	845:853	arg1	sensor					855:860	a sensitive sensor	843:860	a sensitive sensor for the detection of lead	843:886	Upon deposition as thin film on a glassy carbon electrode (GCE), the ion exchange ability of NHAPp0.5-CA-β-CD was exploited to elaborate a sensitive sensor for the detection of lead.
34342829	0	64	theme	Pb	160:161	arg1	detection					147:155	the electrochemical detection	127:155	the electrochemical detection of Pb(II)	127:165	Surface functionalization of natural hydroxyapatite by polymerization of β-cyclodextrin: application as electrode material for the electrochemical detection of Pb(II).
34342829	1	65	theme	Pb	373:374	arg1	detection					360:368	the detection	356:368	the detection of Pb(II)	356:378	A composite material prepared by polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).
34342829	2	66	theme	NH4	513:515	arg1	2HPO4					517:521	(NH4)2HPO4	512:521	(NH4)2HPO4	512:521	Hydroxyapatite was obtained from bovine bones, following a three-step procedure including pre-calcination, chemical treatment with (NH4)2HPO4, and calcination.
34342829	7	67	theme	Significant	1277:1287	arg1	parameters					1289:1298	Significant parameters	1277:1298	Significant parameters that can affect the stripping response of Pb(II)	1277:1347	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	9	68	theme	proposed	1730:1737	arg1	sensor					1739:1744	the proposed sensor	1726:1744	the proposed sensor	1726:1744	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	1	69	from	β-cyclodextrin	219:232	arg1	surface					248:254	the surface	244:254	the surface of natural hydroxyapatite using citric acid as cross linker	244:314	A composite material prepared by polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).
34342829	7	70	theme	L-1	1455:1457	arg1	L-1					1475:1477	2 × 10-8 mol L-1 - 20 × 10-8 mol L-1	1442:1477	2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998)	1442:1490	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	6	71	theme	μM	1225:1226	arg1	Pb					1228:1229	2 μM Pb(II)	1223:1233	2 μM Pb(II)	1223:1233	The reproducibility of the proposed method, based on a series of 8 measurements in a solution containing 2 μM Pb(II) gave a coefficient of variation of 1.27%.
34342829	3	72	theme	hydroxyapatite	586:599	arg1	morphology					559:568	morphology	559:568	morphology	559:568	The structure and morphology of the pristine hydroxyapatite (NHAPP0.5) and its functionalized counterpart (NHAPp0.5-CA-β-CD) were examined using XRD, FTIR, and SEM.
34342829	3	72	theme	hydroxyapatite	586:599	arg1	structure					545:553	structure	545:553	structure	545:553	The structure and morphology of the pristine hydroxyapatite (NHAPP0.5) and its functionalized counterpart (NHAPp0.5-CA-β-CD) were examined using XRD, FTIR, and SEM.
34342829	1	73	from	polymerization	201:214	arg1	surface					248:254	the surface	244:254	the surface of natural hydroxyapatite using citric acid as cross linker	244:314	A composite material prepared by polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).
34342829	6	74	theme	proposed	1145:1152	arg1	method					1154:1159	the proposed method	1141:1159	the proposed method	1141:1159	The reproducibility of the proposed method, based on a series of 8 measurements in a solution containing 2 μM Pb(II) gave a coefficient of variation of 1.27%.
34342829	9	75	from	water	1842:1846	arg1	determination					1778:1790	the determination	1774:1790	the determination of Pb(II) ions in spring water, well water, river water and tap water samples	1774:1868	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	9	76	dep	water	1817:1821	arg1	samples					1862:1868	samples	1862:1868	samples	1862:1868	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	6	77	theme	variation	1257:1265	arg1	coefficient					1242:1252	a coefficient	1240:1252	a coefficient of variation of 1.27%	1240:1274	The reproducibility of the proposed method, based on a series of 8 measurements in a solution containing 2 μM Pb(II) gave a coefficient of variation of 1.27%.
34342829	6	78	theme	%	1274:1274	arg1	variation					1257:1265	variation	1257:1265	variation of 1.27%	1257:1274	The reproducibility of the proposed method, based on a series of 8 measurements in a solution containing 2 μM Pb(II) gave a coefficient of variation of 1.27%.
34342829	5	79	theme	preconcentrated	1039:1053	arg1	species					1055:1061	the preconcentrated species	1035:1061	the preconcentrated species using differential pulse anodic stripping voltammetry	1035:1115	The electroanalytical procedure was based on the chemical accumulation of Pb(II) ions under open-circuit conditions, followed by the detection of the preconcentrated species using differential pulse anodic stripping voltammetry.
34342829	8	80	theme	mol	1581:1583	arg1	×					1573:1573	5.06 ×	1568:1573	5.06 × 10-10 mol L-1 and 100.80 μA.μM-1	1568:1606	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	8	80	theme	mol	1581:1583	arg1	L-1					1585:1587	10-10 mol L-1	1575:1587	10-10 mol L-1	1575:1587	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	1	81	theme	electrode	333:341	arg1	material					180:187	A composite material	168:187	A composite material	168:187	A composite material prepared by polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).
34342829	1	81	theme	electrode	333:341	arg1	material					343:350	electrode material	333:350	electrode material for the detection of Pb(II)	333:378	A composite material prepared by polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).
34342829	9	82	from	water	1817:1821	arg1	determination					1778:1790	the determination	1774:1790	the determination of Pb(II) ions in spring water, well water, river water and tap water samples	1774:1868	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	2	83	with	pre-calcination	471:485	arg1	2HPO4					517:521	(NH4)2HPO4	512:521	(NH4)2HPO4	512:521	Hydroxyapatite was obtained from bovine bones, following a three-step procedure including pre-calcination, chemical treatment with (NH4)2HPO4, and calcination.
34342829	2	84	theme	chemical	488:495	arg1	treatment					497:505	chemical treatment	488:505	chemical treatment with (NH4)2HPO4	488:521	Hydroxyapatite was obtained from bovine bones, following a three-step procedure including pre-calcination, chemical treatment with (NH4)2HPO4, and calcination.
34342829	4	85	theme	thin	725:728	arg1	film					730:733	thin film	725:733	thin film on a glassy carbon electrode (GCE)	725:768	Upon deposition as thin film on a glassy carbon electrode (GCE), the ion exchange ability of NHAPp0.5-CA-β-CD was exploited to elaborate a sensitive sensor for the detection of lead.
34342829	6	86	contain	containing	1212:1221	arg1	solution					1203:1210	a solution	1201:1210	a solution containing 2 μM Pb(II)	1201:1233	The reproducibility of the proposed method, based on a series of 8 measurements in a solution containing 2 μM Pb(II) gave a coefficient of variation of 1.27%.
34342829	6	86	contain	containing	1212:1221	arg2	Pb					1228:1229	2 μM Pb(II)	1223:1233	2 μM Pb(II)	1223:1233	The reproducibility of the proposed method, based on a series of 8 measurements in a solution containing 2 μM Pb(II) gave a coefficient of variation of 1.27%.
34342829	2	87	theme	bovine	414:419	arg1	bones					421:425	bovine bones	414:425	bovine bones	414:425	Hydroxyapatite was obtained from bovine bones, following a three-step procedure including pre-calcination, chemical treatment with (NH4)2HPO4, and calcination.
34342829	0	88	theme	natural	29:35	arg1	hydroxyapatite					37:50	natural hydroxyapatite	29:50	natural hydroxyapatite	29:50	Surface functionalization of natural hydroxyapatite by polymerization of β-cyclodextrin: application as electrode material for the electrochemical detection of Pb(II).
34342829	9	89	theme	ions	1657:1660	arg1	effect					1639:1644	The interfering effect	1623:1644	The interfering effect of several ions expected to affect the determination of lead	1623:1705	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	9	90	theme	well	1824:1827	arg1	water					1829:1833	well water	1824:1833	well water	1824:1833	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	4	91	theme	lead	883:886	arg1	detection					870:878	the detection	866:878	the detection of lead	866:886	Upon deposition as thin film on a glassy carbon electrode (GCE), the ion exchange ability of NHAPp0.5-CA-β-CD was exploited to elaborate a sensitive sensor for the detection of lead.
34342829	1	92	theme	cross	303:307	arg1	linker					309:314	cross linker	303:314	cross linker	303:314	A composite material prepared by polymerization of β-cyclodextrin (β-CD) on the surface of natural hydroxyapatite using citric acid as cross linker, was employed as electrode material for the detection of Pb(II).
34342829	5	93	theme	Pb	963:964	arg1	ions					970:973	Pb(II) ions	963:973	Pb(II) ions	963:973	The electroanalytical procedure was based on the chemical accumulation of Pb(II) ions under open-circuit conditions, followed by the detection of the preconcentrated species using differential pulse anodic stripping voltammetry.
34342829	9	94	theme	interfering	1627:1637	arg1	effect					1639:1644	The interfering effect	1623:1644	The interfering effect of several ions expected to affect the determination of lead	1623:1705	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	5	95	theme	stripping	1095:1103	arg1	voltammetry					1105:1115	differential pulse anodic stripping voltammetry	1069:1115	differential pulse anodic stripping voltammetry	1069:1115	The electroanalytical procedure was based on the chemical accumulation of Pb(II) ions under open-circuit conditions, followed by the detection of the preconcentrated species using differential pulse anodic stripping voltammetry.
34342829	7	96	theme	calibration	1385:1395	arg1	curve					1397:1401	a linear calibration curve	1376:1401	a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998)	1376:1490	Significant parameters that can affect the stripping response of Pb(II) were optimized, leading to a linear calibration curve for lead in the concentration range of 2 × 10-8 mol L-1 - 20 × 10-8 mol L-1 (R2 = 0.998).
34342829	3	97	theme	functionalized	620:633	arg1	counterpart					635:645	its functionalized counterpart	616:645	its functionalized counterpart (NHAPp0.5-CA-β-CD)	616:664	The structure and morphology of the pristine hydroxyapatite (NHAPP0.5) and its functionalized counterpart (NHAPp0.5-CA-β-CD) were examined using XRD, FTIR, and SEM.
34342829	3	97	theme	functionalized	620:633	arg1	NHAPp0.5-CA-β-CD					648:663	NHAPp0.5-CA-β-CD	648:663	NHAPp0.5-CA-β-CD	648:663	The structure and morphology of the pristine hydroxyapatite (NHAPP0.5) and its functionalized counterpart (NHAPp0.5-CA-β-CD) were examined using XRD, FTIR, and SEM.
34342829	0	98	dep	functionalization	8:24	arg1	application					89:99	application	89:99	Surface functionalization of natural hydroxyapatite by polymerization of β-cyclodextrin: application as electrode material for the electrochemical detection of Pb(II).	0:166	Surface functionalization of natural hydroxyapatite by polymerization of β-cyclodextrin: application as electrode material for the electrochemical detection of Pb(II).
34342829	8	99	dep	×	1573:1573	arg1	μA.μM-1					1600:1606	100.80 μA.μM-1	1593:1606	100.80 μA.μM-1	1593:1606	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	8	99	dep	×	1573:1573	arg1	×					1573:1573	5.06 ×	1568:1573	5.06 × 10-10 mol L-1 and 100.80 μA.μM-1	1568:1606	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	8	99	dep	×	1573:1573	arg1	L-1					1585:1587	10-10 mol L-1	1575:1587	10-10 mol L-1	1575:1587	The detection limit (3S/m) and the sensitivity of the proposed sensor were 5.06 × 10-10 mol L-1 and 100.80 μA.μM-1, respectively.
34342829	9	100	theme	tap	1852:1854	arg1	water					1856:1860	tap water	1852:1860	tap water	1852:1860	The interfering effect of several ions expected to affect the determination of lead was evaluated, and the proposed sensor was successfully applied in the determination of Pb(II) ions in spring water, well water, river water and tap water samples.
34342829	4	101	theme	glassy	740:745	arg1	GCE					765:767	GCE	765:767	GCE	765:767	Upon deposition as thin film on a glassy carbon electrode (GCE), the ion exchange ability of NHAPp0.5-CA-β-CD was exploited to elaborate a sensitive sensor for the detection of lead.
34342829	4	101	theme	glassy	740:745	arg1	electrode					754:762	a glassy carbon electrode	738:762	a glassy carbon electrode (GCE)	738:768	Upon deposition as thin film on a glassy carbon electrode (GCE), the ion exchange ability of NHAPp0.5-CA-β-CD was exploited to elaborate a sensitive sensor for the detection of lead.
34342829	2	102	with	calcination	528:538	arg1	2HPO4					517:521	(NH4)2HPO4	512:521	(NH4)2HPO4	512:521	Hydroxyapatite was obtained from bovine bones, following a three-step procedure including pre-calcination, chemical treatment with (NH4)2HPO4, and calcination.
34342829	6	103	from	solution	1203:1210	arg1	series					1173:1178	a series	1171:1178	a series of 8 measurements in a solution containing 2 μM Pb(II)	1171:1233	The reproducibility of the proposed method, based on a series of 8 measurements in a solution containing 2 μM Pb(II) gave a coefficient of variation of 1.27%.
32794524	7	0	theme	control	1071:1077	arg1	group					1079:1083	the control group	1067:1083	the control group	1067:1083	Compared with the control group, oligosaccharides and polysaccharides of FSR changed the relative abundance and diversity of the bacterial community, and increased the numbers of beneficial flora, such as Prevotellaceae and Lactobacillales.
32794524	8	1	theme	intestinal	1424:1433	arg1	flora					1435:1439	intestinal flora	1424:1439	intestinal flora in rats	1424:1447	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	2	2	theme	fermentation	304:315	arg1	technology					317:326	In vitro fermentation technology	295:326	In vitro fermentation technology	295:326	In vitro fermentation technology was used to analyze the fermentation properties of SDF from fermented soybean residue (FSR).
32794524	5	3	from	fermentation	851:862	arg1	broth					884:888	the fermentation broth	867:888	the fermentation broth	867:888	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	1	4	theme	residue	220:226	arg1	fiber					149:153	soluble dietary fiber	133:153	soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa	133:262	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	1	4	theme	residue	220:226	arg1	object					287:292	a research object	276:292	a research object	276:292	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	0	5	theme	Neurospora	67:76	arg1	crassa					78:83	Neurospora crassa	67:83	Neurospora crassa on the intestinal flora in rats	67:115	Effects of soluble dietary fiber from soybean residue fermented by Neurospora crassa on the intestinal flora in rats.
32794524	1	6	used	used	268:271	arg2	object					287:292	a research object	276:292	a research object	276:292	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	1	6	used	used	268:271	arg2	fiber					149:153	soluble dietary fiber	133:153	soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa	133:262	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	8	7	from	flora	1435:1439	arg1	rats					1444:1447	rats	1444:1447	rats	1444:1447	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	1	8	theme	soluble	133:139	arg1	fiber					149:153	soluble dietary fiber	133:153	soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa	133:262	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	1	8	theme	soluble	133:139	arg1	object					287:292	a research object	276:292	a research object	276:292	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	5	9	from	SDF	673:675	arg1	range					684:688	the range 2	680:690	the range 2	680:690	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	8	10	from	composition	1409:1419	arg1	rats					1444:1447	rats	1444:1447	rats	1444:1447	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	4	11	theme	SDF	604:606	arg1	%					654:654	27.21%	649:654	27.21%	649:654	Results showed that the SDF content of fermented soybean residue was 27.21%.
32794524	4	11	theme	SDF	604:606	arg1	content					608:614	the SDF content	600:614	the SDF content of fermented soybean residue	600:643	Results showed that the SDF content of fermented soybean residue was 27.21%.
32794524	0	12	from	residue	46:52	arg1	Effects					0:6	Effects	0:6	Effects of soluble dietary fiber from soybean residue	0:52	Effects of soluble dietary fiber from soybean residue fermented by Neurospora crassa on the intestinal flora in rats.
32794524	8	13	theme	intestinal	1378:1387	arg1	environment					1389:1399	the intestinal environment	1374:1399	the intestinal environment	1374:1399	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	5	14	theme	24	846:847	arg1	h					849:849	h	849:849	h	849:849	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	5	15	theme	fatty	764:768	arg1	acids					770:774	short-chain fatty acids	752:774	short-chain fatty acids (SCFAs)	752:782	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	5	15	theme	fatty	764:768	arg1	SCFAs					777:781	SCFAs	777:781	SCFAs	777:781	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	4	16	theme	residue	637:643	arg1	%					654:654	27.21%	649:654	27.21%	649:654	Results showed that the SDF content of fermented soybean residue was 27.21%.
32794524	4	16	theme	residue	637:643	arg1	content					608:614	the SDF content	600:614	the SDF content of fermented soybean residue	600:643	Results showed that the SDF content of fermented soybean residue was 27.21%.
32794524	7	17	theme	relative	1142:1149	arg1	abundance					1151:1159	relative abundance	1142:1159	relative abundance	1142:1159	Compared with the control group, oligosaccharides and polysaccharides of FSR changed the relative abundance and diversity of the bacterial community, and increased the numbers of beneficial flora, such as Prevotellaceae and Lactobacillales.
32794524	3	18	from	FSR	455:457	arg1	SDF					446:448	SDF	446:448	SDF from FSR	446:457	Moreover, the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats were studied by high-throughput sequencing technology.
32794524	3	18	from	FSR	455:457	arg1	effects					435:441	the effects	431:441	the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats	431:523	Moreover, the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats were studied by high-throughput sequencing technology.
32794524	5	19	theme	h	849:849	arg1	fermentation					851:862	24 h fermentation	846:862	24 h fermentation in the fermentation broth	846:888	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	1	20	theme	dietary	141:147	arg1	fiber					149:153	soluble dietary fiber	133:153	soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa	133:262	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	1	20	theme	dietary	141:147	arg1	object					287:292	a research object	276:292	a research object	276:292	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	0	21	theme	intestinal	92:101	arg1	flora					103:107	the intestinal flora	88:107	the intestinal flora in rats	88:115	Effects of soluble dietary fiber from soybean residue fermented by Neurospora crassa on the intestinal flora in rats.
32794524	8	22	from	environment	1389:1399	arg1	rats					1444:1447	rats	1444:1447	rats	1444:1447	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	8	23	from	rats	1444:1447	arg1	environment					1389:1399	the intestinal environment	1374:1399	the intestinal environment	1374:1399	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	8	23	from	rats	1444:1447	arg1	composition					1409:1419	the composition	1405:1419	the composition of intestinal flora in rats	1405:1447	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	6	24	theme	major	1013:1017	arg1	phyla					1028:1032	the major dominant phyla	1009:1032	the major dominant phyla	1009:1032	The animal-based experiments showed that Bacteroidetes and Firmicutes were the major dominant phyla in all the groups.
32794524	6	24	theme	major	1013:1017	arg1	Firmicutes					993:1002	Firmicutes	993:1002	Firmicutes	993:1002	The animal-based experiments showed that Bacteroidetes and Firmicutes were the major dominant phyla in all the groups.
32794524	6	24	theme	major	1013:1017	arg1	Bacteroidetes					975:987	Bacteroidetes	975:987	Bacteroidetes	975:987	The animal-based experiments showed that Bacteroidetes and Firmicutes were the major dominant phyla in all the groups.
32794524	7	25	dep	abundance	1151:1159	arg1	the					1138:1140	the	1138:1140	the	1138:1140	Compared with the control group, oligosaccharides and polysaccharides of FSR changed the relative abundance and diversity of the bacterial community, and increased the numbers of beneficial flora, such as Prevotellaceae and Lactobacillales.
32794524	6	26	theme	animal-based	938:949	arg1	experiments					951:961	The animal-based experiments	934:961	The animal-based experiments	934:961	The animal-based experiments showed that Bacteroidetes and Firmicutes were the major dominant phyla in all the groups.
32794524	5	27	theme	acids	770:774	arg1	levels					723:728	the levels	719:728	the levels of gas production and short-chain fatty acids (SCFAs)	719:782	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	3	28	theme	intestinal	495:504	arg1	microflora					506:515	intestinal microflora	495:515	intestinal microflora of rats	495:523	Moreover, the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats were studied by high-throughput sequencing technology.
32794524	7	29	theme	bacterial	1182:1190	arg1	community					1192:1200	the bacterial community	1178:1200	the bacterial community	1178:1200	Compared with the control group, oligosaccharides and polysaccharides of FSR changed the relative abundance and diversity of the bacterial community, and increased the numbers of beneficial flora, such as Prevotellaceae and Lactobacillales.
32794524	2	30	theme	soybean	398:404	arg1	FSR					415:417	FSR	415:417	FSR	415:417	In vitro fermentation technology was used to analyze the fermentation properties of SDF from fermented soybean residue (FSR).
32794524	2	30	theme	soybean	398:404	arg1	residue					406:412	fermented soybean residue	388:412	fermented soybean residue (FSR)	388:418	In vitro fermentation technology was used to analyze the fermentation properties of SDF from fermented soybean residue (FSR).
32794524	5	31	from	range	684:688	arg1	addition					661:668	The addition	657:668	The addition of SDF in the range 2 to 10 g L-1	657:702	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	3	32	theme	microflora	506:515	arg1	composition					466:476	composition	466:476	composition	466:476	Moreover, the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats were studied by high-throughput sequencing technology.
32794524	3	32	theme	microflora	506:515	arg1	diversity					482:490	diversity	482:490	diversity	482:490	Moreover, the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats were studied by high-throughput sequencing technology.
32794524	7	33	theme	community	1192:1200	arg1	diversity					1165:1173	diversity	1165:1173	diversity	1165:1173	Compared with the control group, oligosaccharides and polysaccharides of FSR changed the relative abundance and diversity of the bacterial community, and increased the numbers of beneficial flora, such as Prevotellaceae and Lactobacillales.
32794524	7	33	theme	community	1192:1200	arg1	abundance					1151:1159	relative abundance	1142:1159	relative abundance	1142:1159	Compared with the control group, oligosaccharides and polysaccharides of FSR changed the relative abundance and diversity of the bacterial community, and increased the numbers of beneficial flora, such as Prevotellaceae and Lactobacillales.
32794524	0	34	theme	dietary	19:25	arg1	fiber					27:31	soluble dietary fiber	11:31	soluble dietary fiber	11:31	Effects of soluble dietary fiber from soybean residue fermented by Neurospora crassa on the intestinal flora in rats.
32794524	3	35	theme	rats	520:523	arg1	microflora					506:515	intestinal microflora	495:515	intestinal microflora of rats	495:523	Moreover, the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats were studied by high-throughput sequencing technology.
32794524	2	36	dep	In	295:296	arg1	vitro					298:302	vitro	298:302	vitro	298:302	In vitro fermentation technology was used to analyze the fermentation properties of SDF from fermented soybean residue (FSR).
32794524	2	37	theme	SDF	379:381	arg1	properties					365:374	the fermentation properties	348:374	the fermentation properties of SDF from fermented soybean residue (FSR)	348:418	In vitro fermentation technology was used to analyze the fermentation properties of SDF from fermented soybean residue (FSR).
32794524	0	38	theme	soluble	11:17	arg1	fiber					27:31	soluble dietary fiber	11:31	soluble dietary fiber	11:31	Effects of soluble dietary fiber from soybean residue fermented by Neurospora crassa on the intestinal flora in rats.
32794524	1	39	theme	Neurospora	246:255	arg1	crassa					257:262	Neurospora crassa	246:262	Neurospora crassa	246:262	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	5	40	theme	ammonia	816:822	arg1	concentration					826:838	ammonia N concentration	816:838	ammonia N concentration	816:838	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	0	41	from	crassa	78:83	arg1	flora					103:107	the intestinal flora	88:107	the intestinal flora in rats	88:115	Effects of soluble dietary fiber from soybean residue fermented by Neurospora crassa on the intestinal flora in rats.
32794524	3	42	theme	SDF	446:448	arg1	effects					435:441	the effects	431:441	the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats	431:523	Moreover, the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats were studied by high-throughput sequencing technology.
32794524	6	43	from	phyla	1028:1032	arg1	groups					1045:1050	all the groups	1037:1050	all the groups	1037:1050	The animal-based experiments showed that Bacteroidetes and Firmicutes were the major dominant phyla in all the groups.
32794524	5	44	theme	production	737:746	arg1	levels					723:728	the levels	719:728	the levels of gas production and short-chain fatty acids (SCFAs)	719:782	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	8	45	contain	had	1353:1355	arg1	SDF					1312:1314	SDF	1312:1314	SDF of SR fermented by Neurospora crassa	1312:1351	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	8	45	contain	had	1353:1355	arg2	effects					1363:1369	great effects	1357:1369	great effects	1357:1369	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	3	46	from	effects	435:441	arg1	composition					466:476	composition	466:476	composition	466:476	Moreover, the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats were studied by high-throughput sequencing technology.
32794524	3	46	from	effects	435:441	arg1	diversity					482:490	diversity	482:490	diversity	482:490	Moreover, the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats were studied by high-throughput sequencing technology.
32794524	3	46	from	effects	435:441	arg1	FSR					455:457	FSR	455:457	FSR	455:457	Moreover, the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats were studied by high-throughput sequencing technology.
32794524	5	47	theme	control	908:914	arg1	group					916:920	the control group	904:920	the control group (p < 0.05)	904:931	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	5	47	theme	control	908:914	arg1	<					925:925	p < 0.05	923:930	p < 0.05	923:930	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	0	48	theme	fiber	27:31	arg1	Effects					0:6	Effects	0:6	Effects of soluble dietary fiber from soybean residue	0:52	Effects of soluble dietary fiber from soybean residue fermented by Neurospora crassa on the intestinal flora in rats.
32794524	5	49	theme	g	698:698	arg1	L-1					700:702	10 g L-1	695:702	10 g L-1	695:702	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	5	50	from	addition	661:668	arg1	range					684:688	the range 2	680:690	the range 2	680:690	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	2	51	theme	fermented	388:396	arg1	FSR					415:417	FSR	415:417	FSR	415:417	In vitro fermentation technology was used to analyze the fermentation properties of SDF from fermented soybean residue (FSR).
32794524	2	51	theme	fermented	388:396	arg1	residue					406:412	fermented soybean residue	388:412	fermented soybean residue (FSR)	388:418	In vitro fermentation technology was used to analyze the fermentation properties of SDF from fermented soybean residue (FSR).
32794524	7	52	theme	flora	1243:1247	arg1	numbers					1221:1227	the numbers	1217:1227	the numbers	1217:1227	Compared with the control group, oligosaccharides and polysaccharides of FSR changed the relative abundance and diversity of the bacterial community, and increased the numbers of beneficial flora, such as Prevotellaceae and Lactobacillales.
32794524	7	52	theme	flora	1243:1247	arg1	Lactobacillales					1277:1291	Lactobacillales	1277:1291	Lactobacillales	1277:1291	Compared with the control group, oligosaccharides and polysaccharides of FSR changed the relative abundance and diversity of the bacterial community, and increased the numbers of beneficial flora, such as Prevotellaceae and Lactobacillales.
32794524	7	52	theme	flora	1243:1247	arg1	Prevotellaceae					1258:1271	Prevotellaceae	1258:1271	Prevotellaceae	1258:1271	Compared with the control group, oligosaccharides and polysaccharides of FSR changed the relative abundance and diversity of the bacterial community, and increased the numbers of beneficial flora, such as Prevotellaceae and Lactobacillales.
32794524	2	53	theme	fermentation	352:363	arg1	properties					365:374	the fermentation properties	348:374	the fermentation properties of SDF from fermented soybean residue (FSR)	348:418	In vitro fermentation technology was used to analyze the fermentation properties of SDF from fermented soybean residue (FSR).
32794524	8	54	theme	flora	1435:1439	arg1	environment					1389:1399	the intestinal environment	1374:1399	the intestinal environment	1374:1399	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	8	54	theme	flora	1435:1439	arg1	composition					1409:1419	the composition	1405:1419	the composition of intestinal flora in rats	1405:1447	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	7	55	theme	beneficial	1232:1241	arg1	flora					1243:1247	beneficial flora	1232:1247	beneficial flora	1232:1247	Compared with the control group, oligosaccharides and polysaccharides of FSR changed the relative abundance and diversity of the bacterial community, and increased the numbers of beneficial flora, such as Prevotellaceae and Lactobacillales.
32794524	2	56	theme	In	295:296	arg1	technology					317:326	In vitro fermentation technology	295:326	In vitro fermentation technology	295:326	In vitro fermentation technology was used to analyze the fermentation properties of SDF from fermented soybean residue (FSR).
32794524	0	57	theme	soybean	38:44	arg1	residue					46:52	soybean residue	38:52	soybean residue	38:52	Effects of soluble dietary fiber from soybean residue fermented by Neurospora crassa on the intestinal flora in rats.
32794524	8	58	theme	great	1357:1361	arg1	effects					1363:1369	great effects	1357:1369	great effects	1357:1369	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	0	59	from	flora	103:107	arg1	rats					112:115	rats	112:115	rats	112:115	Effects of soluble dietary fiber from soybean residue fermented by Neurospora crassa on the intestinal flora in rats.
32794524	1	60	dep	fiber	149:153	arg1	including					161:169	including	161:169	including oligosaccharides and polysaccharides	161:206	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	8	61	theme	SR	1319:1320	arg1	SDF					1312:1314	SDF	1312:1314	SDF of SR fermented by Neurospora crassa	1312:1351	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	3	62	theme	high-throughput	541:555	arg1	technology					568:577	high-throughput sequencing technology	541:577	high-throughput sequencing technology	541:577	Moreover, the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats were studied by high-throughput sequencing technology.
32794524	3	63	theme	sequencing	557:566	arg1	technology					568:577	high-throughput sequencing technology	541:577	high-throughput sequencing technology	541:577	Moreover, the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats were studied by high-throughput sequencing technology.
32794524	3	64	dep	composition	466:476	arg1	the					462:464	the	462:464	the	462:464	Moreover, the effects of SDF from FSR on the composition and diversity of intestinal microflora of rats were studied by high-throughput sequencing technology.
32794524	5	65	theme	N	824:824	arg1	concentration					826:838	ammonia N concentration	816:838	ammonia N concentration	816:838	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	5	66	theme	SDF	673:675	arg1	addition					661:668	The addition	657:668	The addition of SDF in the range 2 to 10 g L-1	657:702	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	5	67	theme	p	923:923	arg1	group					916:920	the control group	904:920	the control group (p < 0.05)	904:931	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	5	67	theme	p	923:923	arg1	<					925:925	p < 0.05	923:930	p < 0.05	923:930	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	2	68	used	used	332:335	arg2	technology					317:326	In vitro fermentation technology	295:326	In vitro fermentation technology	295:326	In vitro fermentation technology was used to analyze the fermentation properties of SDF from fermented soybean residue (FSR).
32794524	7	69	theme	FSR	1126:1128	arg1	polysaccharides					1107:1121	polysaccharides	1107:1121	polysaccharides	1107:1121	Compared with the control group, oligosaccharides and polysaccharides of FSR changed the relative abundance and diversity of the bacterial community, and increased the numbers of beneficial flora, such as Prevotellaceae and Lactobacillales.
32794524	7	69	theme	FSR	1126:1128	arg1	oligosaccharides					1086:1101	oligosaccharides	1086:1101	oligosaccharides	1086:1101	Compared with the control group, oligosaccharides and polysaccharides of FSR changed the relative abundance and diversity of the bacterial community, and increased the numbers of beneficial flora, such as Prevotellaceae and Lactobacillales.
32794524	8	70	theme	Neurospora	1335:1344	arg1	crassa					1346:1351	Neurospora crassa	1335:1351	Neurospora crassa	1335:1351	It was shown that SDF of SR fermented by Neurospora crassa had great effects on the intestinal environment and the composition of intestinal flora in rats.
32794524	2	71	from	residue	406:412	arg1	properties					365:374	the fermentation properties	348:374	the fermentation properties of SDF from fermented soybean residue (FSR)	348:418	In vitro fermentation technology was used to analyze the fermentation properties of SDF from fermented soybean residue (FSR).
32794524	5	72	theme	short-chain	752:762	arg1	acids					770:774	short-chain fatty acids	752:774	short-chain fatty acids (SCFAs)	752:782	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	5	72	theme	short-chain	752:762	arg1	SCFAs					777:781	SCFAs	777:781	SCFAs	777:781	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	5	73	theme	fermentation	871:882	arg1	broth					884:888	the fermentation broth	867:888	the fermentation broth	867:888	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	5	74	theme	gas	733:735	arg1	production					737:746	gas production	733:746	gas production	733:746	The addition of SDF in the range 2 to 10 g L-1 could increase the levels of gas production and short-chain fatty acids (SCFAs), as well as decrease the pH and ammonia N concentration after 24 h fermentation in the fermentation broth compared with the control group (p < 0.05).
32794524	4	75	theme	soybean	629:635	arg1	residue					637:643	fermented soybean residue	619:643	fermented soybean residue	619:643	Results showed that the SDF content of fermented soybean residue was 27.21%.
32794524	6	76	theme	dominant	1019:1026	arg1	phyla					1028:1032	the major dominant phyla	1009:1032	the major dominant phyla	1009:1032	The animal-based experiments showed that Bacteroidetes and Firmicutes were the major dominant phyla in all the groups.
32794524	6	76	theme	dominant	1019:1026	arg1	Firmicutes					993:1002	Firmicutes	993:1002	Firmicutes	993:1002	The animal-based experiments showed that Bacteroidetes and Firmicutes were the major dominant phyla in all the groups.
32794524	6	76	theme	dominant	1019:1026	arg1	Bacteroidetes					975:987	Bacteroidetes	975:987	Bacteroidetes	975:987	The animal-based experiments showed that Bacteroidetes and Firmicutes were the major dominant phyla in all the groups.
32794524	1	77	theme	research	278:285	arg1	object					287:292	a research object	276:292	a research object	276:292	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	1	77	theme	research	278:285	arg1	fiber					149:153	soluble dietary fiber	133:153	soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa	133:262	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	1	78	dep	including	161:169	arg1	SDF					156:158	SDF	156:158	SDF	156:158	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	4	79	theme	fermented	619:627	arg1	residue					637:643	fermented soybean residue	619:643	fermented soybean residue	619:643	Results showed that the SDF content of fermented soybean residue was 27.21%.
32794524	1	80	theme	soybean	212:218	arg1	SR					229:230	SR	229:230	SR	229:230	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
32794524	1	80	theme	soybean	212:218	arg1	residue					220:226	soybean residue	212:226	soybean residue (SR) fermented by Neurospora crassa	212:262	In this study, soluble dietary fiber (SDF, including oligosaccharides and polysaccharides) of soybean residue (SR) fermented by Neurospora crassa was used as a research object.
33685369	7	0	theme	compressive	1053:1063	arg1	modulus					1065:1071	compressive modulus	1053:1071	compressive modulus	1053:1071	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
33685369	1	1	theme	drug	170:173	arg1	delivery					175:182	drug delivery	170:182	drug delivery	170:182	Pullulan hydrogels are widely used in tissue engineering and drug delivery.
33685369	0	2	theme	tissue	89:94	arg1	engineering					96:106	cartilage tissue engineering	79:106	cartilage tissue engineering	79:106	Methacrylated pullulan/polyethylene (glycol) diacrylate composite hydrogel for cartilage tissue engineering.
33685369	7	3	from	increase	1041:1048	arg1	G					1000:1000	G'	1000:1001	G'	1000:1001	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
33685369	7	3	from	increase	1041:1048	arg1	modulus					991:997	storage modulus	983:997	storage modulus (G') (reach to 16.0 × 103 Pa)	983:1027	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
33685369	7	3	from	increase	1041:1048	arg1	modulus					1065:1071	compressive modulus	1053:1071	compressive modulus	1053:1071	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
33685369	8	4	theme	stem	1224:1227	arg1	MSCs					1236:1239	MSCs	1236:1239	MSCs	1236:1239	In cell culture in vitro, the rabbit's mesenchymal stem cells (MSCs) encapsulated in the PulMA/PEGDA hydrogel could adhere and proliferate, indicating that the PulMA/PEGDA hydrogel had a good biocompatibility.
33685369	8	4	theme	stem	1224:1227	arg1	cells					1229:1233	the rabbit's mesenchymal stem cells	1199:1233	the rabbit's mesenchymal stem cells (MSCs) encapsulated in the PulMA/PEGDA hydrogel	1199:1281	In cell culture in vitro, the rabbit's mesenchymal stem cells (MSCs) encapsulated in the PulMA/PEGDA hydrogel could adhere and proliferate, indicating that the PulMA/PEGDA hydrogel had a good biocompatibility.
33685369	4	5	theme	methacrylated	572:584	arg1	PulMA					596:600	PulMA	596:600	PulMA	596:600	In this study, pullulan was modified with methacrylic anhydride (MA) to obtain photo-crosslinkable methacrylated pullulan (PulMA).
33685369	4	5	theme	methacrylated	572:584	arg1	pullulan					586:593	photo-crosslinkable methacrylated pullulan	552:593	photo-crosslinkable methacrylated pullulan (PulMA)	552:601	In this study, pullulan was modified with methacrylic anhydride (MA) to obtain photo-crosslinkable methacrylated pullulan (PulMA).
33685369	3	6	theme	hybrid	362:367	arg1	system					378:383	a hybrid hydrogel system	360:383	a hybrid hydrogel system	360:383	Herein, we fabricated a hybrid hydrogel system by combining pullulan with synthetic polymers polyethylene (glycol) diacrylate (PEGDA).
33685369	5	7	theme	phosphinate	656:666	arg1	photoinitiator					705:718	a water-soluble UV photoinitiator	686:718	a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy	686:783	Moreover, the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP) was used as a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy.
33685369	5	7	theme	phosphinate	656:666	arg1	lithium					618:624	the lithium	614:624	the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP)	614:672	Moreover, the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP) was used as a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy.
33685369	6	8	theme	PulMA	809:813	arg1	hydrogel					815:822	the pure PulMA hydrogel	800:822	the pure PulMA hydrogel	800:822	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	3	9	theme	hydrogel	369:376	arg1	system					378:383	a hybrid hydrogel system	360:383	a hybrid hydrogel system	360:383	Herein, we fabricated a hybrid hydrogel system by combining pullulan with synthetic polymers polyethylene (glycol) diacrylate (PEGDA).
33685369	10	10	theme	promising	1671:1679	arg1	hydrogels					1598:1606	the photo-crosslinking PulMA/PEGDA hydrogels	1563:1606	the photo-crosslinking PulMA/PEGDA hydrogels	1563:1606	This study demonstrated that the photo-crosslinking PulMA/PEGDA hydrogels, with good mechanical properties and slow degradation rate are promising scaffolds for cartilage repair and regeneration.
33685369	10	10	theme	promising	1671:1679	arg1	scaffolds					1681:1689	promising scaffolds	1671:1689	promising scaffolds for cartilage repair and regeneration	1671:1727	This study demonstrated that the photo-crosslinking PulMA/PEGDA hydrogels, with good mechanical properties and slow degradation rate are promising scaffolds for cartilage repair and regeneration.
33685369	6	11	theme	pure	804:807	arg1	hydrogel					815:822	the pure PulMA hydrogel	800:822	the pure PulMA hydrogel	800:822	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	2	12	theme	degradation	291:301	arg1	rate					303:306	their fast degradation rate	280:306	their fast degradation rate	280:306	However, these hydrogels do not meet the requirements of articular cartilage repair because of their fast degradation rate and poor mechanical strength.
33685369	10	13	with	hydrogels	1598:1606	arg1	properties					1630:1639	good mechanical properties	1614:1639	good mechanical properties	1614:1639	This study demonstrated that the photo-crosslinking PulMA/PEGDA hydrogels, with good mechanical properties and slow degradation rate are promising scaffolds for cartilage repair and regeneration.
33685369	10	13	with	hydrogels	1598:1606	arg1	rate					1662:1665	slow degradation rate	1645:1665	slow degradation rate	1645:1665	This study demonstrated that the photo-crosslinking PulMA/PEGDA hydrogels, with good mechanical properties and slow degradation rate are promising scaffolds for cartilage repair and regeneration.
33685369	6	14	from	rate	889:892	arg1	%					945:945	63.9% to 86.8%	932:945	63.9% to 86.8%	932:945	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	6	15	theme	degradation	877:887	arg1	rate					889:892	a slower degradation rate	868:892	a slower degradation rate	868:892	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	4	16	mod	modified	501:508	arg3	anhydride					527:535	methacrylic anhydride	515:535	methacrylic anhydride (MA) to obtain photo-crosslinkable methacrylated pullulan (PulMA)	515:601	In this study, pullulan was modified with methacrylic anhydride (MA) to obtain photo-crosslinkable methacrylated pullulan (PulMA).
33685369	4	16	mod	modified	501:508	arg3	MA					538:539	MA	538:539	MA	538:539	In this study, pullulan was modified with methacrylic anhydride (MA) to obtain photo-crosslinkable methacrylated pullulan (PulMA).
33685369	4	16	mod	modified	501:508	arg1	pullulan					488:495	pullulan	488:495	pullulan	488:495	In this study, pullulan was modified with methacrylic anhydride (MA) to obtain photo-crosslinkable methacrylated pullulan (PulMA).
33685369	10	17	theme	good	1614:1617	arg1	properties					1630:1639	good mechanical properties	1614:1639	good mechanical properties	1614:1639	This study demonstrated that the photo-crosslinking PulMA/PEGDA hydrogels, with good mechanical properties and slow degradation rate are promising scaffolds for cartilage repair and regeneration.
33685369	2	18	theme	fast	286:289	arg1	rate					303:306	their fast degradation rate	280:306	their fast degradation rate	280:306	However, these hydrogels do not meet the requirements of articular cartilage repair because of their fast degradation rate and poor mechanical strength.
33685369	7	19	dep	modulus	991:997	arg1	reach					1005:1009	reach	1005:1009	reach to 16.0 × 103 Pa	1005:1026	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
33685369	0	20	theme	composite	56:64	arg1	hydrogel					66:73	composite hydrogel	56:73	composite hydrogel for cartilage tissue engineering	56:106	Methacrylated pullulan/polyethylene (glycol) diacrylate composite hydrogel for cartilage tissue engineering.
33685369	6	21	theme	slower	870:875	arg1	rate					889:892	a slower degradation rate	868:892	a slower degradation rate	868:892	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	9	22	theme	chondrogenic	1459:1470	arg1	phenotype					1472:1480	chondrogenic phenotype	1459:1480	chondrogenic phenotype of MSCs	1459:1488	Furthermore, the hydrogels supported glycosaminoglycan (GAG) synthesis, and chondrogenic phenotype of MSCs with TGF-β3-containing chondrogenic medium.
33685369	8	23	theme	good	1360:1363	arg1	biocompatibility					1365:1380	a good biocompatibility	1358:1380	a good biocompatibility	1358:1380	In cell culture in vitro, the rabbit's mesenchymal stem cells (MSCs) encapsulated in the PulMA/PEGDA hydrogel could adhere and proliferate, indicating that the PulMA/PEGDA hydrogel had a good biocompatibility.
33685369	3	24	theme	diacrylate	453:462	arg1	polymers					422:429	synthetic polymers	412:429	synthetic polymers polyethylene (glycol) diacrylate (PEGDA)	412:470	Herein, we fabricated a hybrid hydrogel system by combining pullulan with synthetic polymers polyethylene (glycol) diacrylate (PEGDA).
33685369	5	25	used	used	678:681	arg2	photoinitiator					705:718	a water-soluble UV photoinitiator	686:718	a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy	686:783	Moreover, the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP) was used as a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy.
33685369	5	25	used	used	678:681	arg2	lithium					618:624	the lithium	614:624	the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP)	614:672	Moreover, the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP) was used as a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy.
33685369	5	26	theme	photopolymerization	756:774	arg1	strategy					776:783	photopolymerization strategy	756:783	photopolymerization strategy	756:783	Moreover, the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP) was used as a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy.
33685369	6	27	from	%	945:945	arg1	rate					889:892	a slower degradation rate	868:892	a slower degradation rate	868:892	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	6	27	from	%	945:945	arg1	increase					901:908	an increase	898:908	an increase of residual mass from 63.9% to 86.8%	898:945	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	6	27	from	%	945:945	arg1	mass					922:925	residual mass	913:925	residual mass from 63.9% to 86.8%	913:945	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	5	28	theme	PulMA/PEGDA	732:742	arg1	hydrogel					744:751	the PulMA/PEGDA hydrogel	728:751	the PulMA/PEGDA hydrogel	728:751	Moreover, the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP) was used as a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy.
33685369	6	29	from	increase	901:908	arg1	%					945:945	63.9% to 86.8%	932:945	63.9% to 86.8%	932:945	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	10	30	theme	photo-crosslinking	1567:1584	arg1	hydrogels					1598:1606	the photo-crosslinking PulMA/PEGDA hydrogels	1563:1606	the photo-crosslinking PulMA/PEGDA hydrogels	1563:1606	This study demonstrated that the photo-crosslinking PulMA/PEGDA hydrogels, with good mechanical properties and slow degradation rate are promising scaffolds for cartilage repair and regeneration.
33685369	10	30	theme	photo-crosslinking	1567:1584	arg1	scaffolds					1681:1689	promising scaffolds	1671:1689	promising scaffolds for cartilage repair and regeneration	1671:1727	This study demonstrated that the photo-crosslinking PulMA/PEGDA hydrogels, with good mechanical properties and slow degradation rate are promising scaffolds for cartilage repair and regeneration.
33685369	0	31	theme	Methacrylated	0:12	arg1	glycol					37:42	glycol	37:42	glycol	37:42	Methacrylated pullulan/polyethylene (glycol) diacrylate composite hydrogel for cartilage tissue engineering.
33685369	0	31	theme	Methacrylated	0:12	arg1	pullulan/polyethylene					14:34	Methacrylated pullulan/polyethylene	0:34	Methacrylated pullulan/polyethylene (glycol)	0:43	Methacrylated pullulan/polyethylene (glycol) diacrylate composite hydrogel for cartilage tissue engineering.
33685369	9	32	theme	MSCs	1485:1488	arg1	phenotype					1472:1480	chondrogenic phenotype	1459:1480	chondrogenic phenotype of MSCs	1459:1488	Furthermore, the hydrogels supported glycosaminoglycan (GAG) synthesis, and chondrogenic phenotype of MSCs with TGF-β3-containing chondrogenic medium.
33685369	1	33	theme	Pullulan	109:116	arg1	hydrogels					118:126	Pullulan hydrogels	109:126	Pullulan hydrogels	109:126	Pullulan hydrogels are widely used in tissue engineering and drug delivery.
33685369	6	34	theme	86.8	941:944	arg1	%					936:936	%	936:936	%	936:936	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	2	35	theme	poor	312:315	arg1	strength					328:335	poor mechanical strength	312:335	poor mechanical strength	312:335	However, these hydrogels do not meet the requirements of articular cartilage repair because of their fast degradation rate and poor mechanical strength.
33685369	9	36	theme	TGF-β3-containing	1495:1511	arg1	medium					1526:1531	TGF-β3-containing chondrogenic medium	1495:1531	TGF-β3-containing chondrogenic medium	1495:1531	Furthermore, the hydrogels supported glycosaminoglycan (GAG) synthesis, and chondrogenic phenotype of MSCs with TGF-β3-containing chondrogenic medium.
33685369	10	37	theme	mechanical	1619:1628	arg1	properties					1630:1639	good mechanical properties	1614:1639	good mechanical properties	1614:1639	This study demonstrated that the photo-crosslinking PulMA/PEGDA hydrogels, with good mechanical properties and slow degradation rate are promising scaffolds for cartilage repair and regeneration.
33685369	2	38	theme	mechanical	317:326	arg1	strength					328:335	poor mechanical strength	312:335	poor mechanical strength	312:335	However, these hydrogels do not meet the requirements of articular cartilage repair because of their fast degradation rate and poor mechanical strength.
33685369	4	39	theme	photo-crosslinkable	552:570	arg1	PulMA					596:600	PulMA	596:600	PulMA	596:600	In this study, pullulan was modified with methacrylic anhydride (MA) to obtain photo-crosslinkable methacrylated pullulan (PulMA).
33685369	4	39	theme	photo-crosslinkable	552:570	arg1	pullulan					586:593	photo-crosslinkable methacrylated pullulan	552:593	photo-crosslinkable methacrylated pullulan (PulMA)	552:601	In this study, pullulan was modified with methacrylic anhydride (MA) to obtain photo-crosslinkable methacrylated pullulan (PulMA).
33685369	10	40	theme	cartilage	1695:1703	arg1	repair					1705:1710	cartilage repair	1695:1710	cartilage repair	1695:1710	This study demonstrated that the photo-crosslinking PulMA/PEGDA hydrogels, with good mechanical properties and slow degradation rate are promising scaffolds for cartilage repair and regeneration.
33685369	8	41	theme	PulMA/PEGDA	1262:1272	arg1	hydrogel					1274:1281	the PulMA/PEGDA hydrogel	1258:1281	the PulMA/PEGDA hydrogel	1258:1281	In cell culture in vitro, the rabbit's mesenchymal stem cells (MSCs) encapsulated in the PulMA/PEGDA hydrogel could adhere and proliferate, indicating that the PulMA/PEGDA hydrogel had a good biocompatibility.
33685369	7	42	dep	was	954:956	arg1	reach					1074:1078	reach	1074:1078	reach	1074:1078	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
33685369	7	43	from	increase	971:978	arg1	G					1000:1000	G'	1000:1001	G'	1000:1001	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
33685369	7	43	from	increase	971:978	arg1	modulus					991:997	storage modulus	983:997	storage modulus (G') (reach to 16.0 × 103 Pa)	983:1027	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
33685369	7	43	from	increase	971:978	arg1	modulus					1065:1071	compressive modulus	1053:1071	compressive modulus	1053:1071	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
33685369	7	44	theme	PEGDA	1137:1141	arg1	concentration					1120:1132	the concentration	1116:1132	the concentration of PEGDA	1116:1141	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
33685369	5	45	theme	water-soluble	688:700	arg1	photoinitiator					705:718	a water-soluble UV photoinitiator	686:718	a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy	686:783	Moreover, the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP) was used as a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy.
33685369	5	45	theme	water-soluble	688:700	arg1	lithium					618:624	the lithium	614:624	the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP)	614:672	Moreover, the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP) was used as a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy.
33685369	8	46	theme	PulMA/PEGDA	1333:1343	arg1	hydrogel					1345:1352	the PulMA/PEGDA hydrogel	1329:1352	the PulMA/PEGDA hydrogel	1329:1352	In cell culture in vitro, the rabbit's mesenchymal stem cells (MSCs) encapsulated in the PulMA/PEGDA hydrogel could adhere and proliferate, indicating that the PulMA/PEGDA hydrogel had a good biocompatibility.
33685369	2	47	theme	articular	242:250	arg1	repair					262:267	articular cartilage repair	242:267	articular cartilage repair	242:267	However, these hydrogels do not meet the requirements of articular cartilage repair because of their fast degradation rate and poor mechanical strength.
33685369	6	48	theme	63.9	932:935	arg1	%					936:936	%	936:936	%	936:936	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	5	49	theme	UV	702:703	arg1	photoinitiator					705:718	a water-soluble UV photoinitiator	686:718	a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy	686:783	Moreover, the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP) was used as a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy.
33685369	5	49	theme	UV	702:703	arg1	lithium					618:624	the lithium	614:624	the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP)	614:672	Moreover, the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP) was used as a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy.
33685369	6	50	theme	concentration	847:859	arg1	increase					829:836	the increase	825:836	the increase of PEGDA concentration	825:859	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	9	51	theme	chondrogenic	1513:1524	arg1	medium					1526:1531	TGF-β3-containing chondrogenic medium	1495:1531	TGF-β3-containing chondrogenic medium	1495:1531	Furthermore, the hydrogels supported glycosaminoglycan (GAG) synthesis, and chondrogenic phenotype of MSCs with TGF-β3-containing chondrogenic medium.
33685369	8	52	theme	cell	1176:1179	arg1	culture					1181:1187	cell culture in vitro	1176:1196	cell culture in vitro	1176:1196	In cell culture in vitro, the rabbit's mesenchymal stem cells (MSCs) encapsulated in the PulMA/PEGDA hydrogel could adhere and proliferate, indicating that the PulMA/PEGDA hydrogel had a good biocompatibility.
33685369	4	53	theme	methacrylic	515:525	arg1	MA					538:539	MA	538:539	MA	538:539	In this study, pullulan was modified with methacrylic anhydride (MA) to obtain photo-crosslinkable methacrylated pullulan (PulMA).
33685369	4	53	theme	methacrylic	515:525	arg1	anhydride					527:535	methacrylic anhydride	515:535	methacrylic anhydride (MA) to obtain photo-crosslinkable methacrylated pullulan (PulMA)	515:601	In this study, pullulan was modified with methacrylic anhydride (MA) to obtain photo-crosslinkable methacrylated pullulan (PulMA).
33685369	6	54	theme	PEGDA	841:845	arg1	concentration					847:859	PEGDA concentration	841:859	PEGDA concentration	841:859	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	7	55	theme	storage	983:989	arg1	G					1000:1000	G'	1000:1001	G'	1000:1001	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
33685369	7	55	theme	storage	983:989	arg1	modulus					991:997	storage modulus	983:997	storage modulus (G') (reach to 16.0 × 103 Pa)	983:1027	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
33685369	10	56	theme	degradation	1650:1660	arg1	rate					1662:1665	slow degradation rate	1645:1665	slow degradation rate	1645:1665	This study demonstrated that the photo-crosslinking PulMA/PEGDA hydrogels, with good mechanical properties and slow degradation rate are promising scaffolds for cartilage repair and regeneration.
33685369	3	57	theme	synthetic	412:420	arg1	polymers					422:429	synthetic polymers	412:429	synthetic polymers polyethylene (glycol) diacrylate (PEGDA)	412:470	Herein, we fabricated a hybrid hydrogel system by combining pullulan with synthetic polymers polyethylene (glycol) diacrylate (PEGDA).
33685369	6	58	theme	mass	922:925	arg1	rate					889:892	a slower degradation rate	868:892	a slower degradation rate	868:892	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	6	58	theme	mass	922:925	arg1	increase					901:908	an increase	898:908	an increase of residual mass from 63.9% to 86.8%	898:945	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	3	59	dep	diacrylate	453:462	arg1	PEGDA					465:469	PEGDA	465:469	PEGDA	465:469	Herein, we fabricated a hybrid hydrogel system by combining pullulan with synthetic polymers polyethylene (glycol) diacrylate (PEGDA).
33685369	7	60	theme	8-fold	964:969	arg1	increase					971:978	about 8-fold increase	958:978	about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa)	958:1027	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
33685369	10	61	theme	slow	1645:1648	arg1	rate					1662:1665	slow degradation rate	1645:1665	slow degradation rate	1645:1665	This study demonstrated that the photo-crosslinking PulMA/PEGDA hydrogels, with good mechanical properties and slow degradation rate are promising scaffolds for cartilage repair and regeneration.
33685369	6	62	theme	residual	913:920	arg1	mass					922:925	residual mass	913:925	residual mass from 63.9% to 86.8%	913:945	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	6	63	dep	%	936:936	arg1	to					938:939	to	938:939	to	938:939	Compared with the pure PulMA hydrogel, the increase of PEGDA concentration led to a slower degradation rate and an increase of residual mass from 63.9% to 86.8%.
33685369	1	64	used	used	139:142	arg2	hydrogels					118:126	Pullulan hydrogels	109:126	Pullulan hydrogels	109:126	Pullulan hydrogels are widely used in tissue engineering and drug delivery.
33685369	1	65	theme	tissue	147:152	arg1	engineering					154:164	tissue engineering	147:164	tissue engineering	147:164	Pullulan hydrogels are widely used in tissue engineering and drug delivery.
33685369	0	66	theme	cartilage	79:87	arg1	engineering					96:106	cartilage tissue engineering	79:106	cartilage tissue engineering	79:106	Methacrylated pullulan/polyethylene (glycol) diacrylate composite hydrogel for cartilage tissue engineering.
33685369	2	67	theme	repair	262:267	arg1	requirements					226:237	the requirements	222:237	the requirements of articular cartilage repair	222:267	However, these hydrogels do not meet the requirements of articular cartilage repair because of their fast degradation rate and poor mechanical strength.
33685369	9	68	theme	glycosaminoglycan	1420:1436	arg1	synthesis					1444:1452	glycosaminoglycan (GAG) synthesis	1420:1452	glycosaminoglycan (GAG) synthesis	1420:1452	Furthermore, the hydrogels supported glycosaminoglycan (GAG) synthesis, and chondrogenic phenotype of MSCs with TGF-β3-containing chondrogenic medium.
33685369	8	69	theme	mesenchymal	1212:1222	arg1	MSCs					1236:1239	MSCs	1236:1239	MSCs	1236:1239	In cell culture in vitro, the rabbit's mesenchymal stem cells (MSCs) encapsulated in the PulMA/PEGDA hydrogel could adhere and proliferate, indicating that the PulMA/PEGDA hydrogel had a good biocompatibility.
33685369	8	69	theme	mesenchymal	1212:1222	arg1	cells					1229:1233	the rabbit's mesenchymal stem cells	1199:1233	the rabbit's mesenchymal stem cells (MSCs) encapsulated in the PulMA/PEGDA hydrogel	1199:1281	In cell culture in vitro, the rabbit's mesenchymal stem cells (MSCs) encapsulated in the PulMA/PEGDA hydrogel could adhere and proliferate, indicating that the PulMA/PEGDA hydrogel had a good biocompatibility.
33685369	10	70	theme	PulMA/PEGDA	1586:1596	arg1	hydrogels					1598:1606	the photo-crosslinking PulMA/PEGDA hydrogels	1563:1606	the photo-crosslinking PulMA/PEGDA hydrogels	1563:1606	This study demonstrated that the photo-crosslinking PulMA/PEGDA hydrogels, with good mechanical properties and slow degradation rate are promising scaffolds for cartilage repair and regeneration.
33685369	10	70	theme	PulMA/PEGDA	1586:1596	arg1	scaffolds					1681:1689	promising scaffolds	1671:1689	promising scaffolds for cartilage repair and regeneration	1671:1727	This study demonstrated that the photo-crosslinking PulMA/PEGDA hydrogels, with good mechanical properties and slow degradation rate are promising scaffolds for cartilage repair and regeneration.
33685369	2	71	theme	cartilage	252:260	arg1	repair					262:267	articular cartilage repair	242:267	articular cartilage repair	242:267	However, these hydrogels do not meet the requirements of articular cartilage repair because of their fast degradation rate and poor mechanical strength.
33685369	5	72	dep	phosphinate	656:666	arg1	LAP					669:671	LAP	669:671	LAP	669:671	Moreover, the lithium phenyl(2,4,6-trimethylbenzoyl)phosphinate (LAP) was used as a water-soluble UV photoinitiator to form the PulMA/PEGDA hydrogel by photopolymerization strategy.
33685369	8	73	contain	had	1354:1356	arg2	biocompatibility					1365:1380	a good biocompatibility	1358:1380	a good biocompatibility	1358:1380	In cell culture in vitro, the rabbit's mesenchymal stem cells (MSCs) encapsulated in the PulMA/PEGDA hydrogel could adhere and proliferate, indicating that the PulMA/PEGDA hydrogel had a good biocompatibility.
33685369	8	73	contain	had	1354:1356	arg1	hydrogel					1345:1352	the PulMA/PEGDA hydrogel	1329:1352	the PulMA/PEGDA hydrogel	1329:1352	In cell culture in vitro, the rabbit's mesenchymal stem cells (MSCs) encapsulated in the PulMA/PEGDA hydrogel could adhere and proliferate, indicating that the PulMA/PEGDA hydrogel had a good biocompatibility.
33685369	7	74	from	%	1148:1148	arg1	hydrogel					1163:1170	the hydrogel	1159:1170	the hydrogel	1159:1170	There was about 8-fold increase in storage modulus (G') (reach to 16.0 × 103 Pa) and 13-fold increase in compressive modulus (reach to 1.17 ± 0.17 MPa) with increasing the concentration of PEGDA to 15% (w/v) in the hydrogel.
34741182	7	0	dep	europaeus	986:994	arg1	specifically					968:979	specifically	968:979	specifically	968:979	The sensor uses a lectin for affinity, specifically Ulex europaeus agglutinin I (UEA), with electrochemical readout.
34741182	7	0	dep	europaeus	986:994	arg1	UEA					1011:1013	UEA	1011:1013	UEA	1011:1013	The sensor uses a lectin for affinity, specifically Ulex europaeus agglutinin I (UEA), with electrochemical readout.
34741182	7	0	dep	europaeus	986:994	arg1	I					1008:1008	agglutinin I	996:1008	Ulex europaeus agglutinin I (UEA)	981:1014	The sensor uses a lectin for affinity, specifically Ulex europaeus agglutinin I (UEA), with electrochemical readout.
34741182	4	1	theme	HMOs	628:631	arg1	presence					598:605	presence	598:605	presence	598:605	However, there is currently no technology to analyze the presence and concentration of HMOs in human milk at the point-of-care (POC).
34741182	4	1	theme	HMOs	628:631	arg1	concentration					611:623	concentration	611:623	concentration	611:623	However, there is currently no technology to analyze the presence and concentration of HMOs in human milk at the point-of-care (POC).
34741182	4	2	theme	human	636:640	arg1	milk					642:645	human milk	636:645	human milk	636:645	However, there is currently no technology to analyze the presence and concentration of HMOs in human milk at the point-of-care (POC).
34741182	1	3	theme	oligosaccharide	165:179	arg1	composition					187:197	human milk oligosaccharide (HMO) composition	154:197	human milk oligosaccharide (HMO) composition	154:197	We present an electrochemical impedimetric-based biosensor for monitoring the variation in human milk oligosaccharide (HMO) composition.
34741182	5	4	theme	such	687:690	arg1	technology					692:701	such technology	687:701	such technology	687:701	The lack of such technology represents a major impediment to advancing human milk research and improving maternal-infant health.
34741182	11	5	theme	milk	1476:1479	arg1	assay					1489:1493	This bedside human milk testing assay	1457:1493	This bedside human milk testing assay	1457:1493	This bedside human milk testing assay enables POC, "sample-to-answer" quantitative HMO measurement, and will be a valuable tool to assess milk composition.
34741182	2	6	from	diarrhea	320:327	arg1	one					330:332	one	330:332	one	330:332	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	2	6	from	diarrhea	320:327	arg1	growth					258:263	infant growth	251:263	infant growth	251:263	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	2	6	from	diarrhea	320:327	arg1	development					276:286	cognitive development	266:286	cognitive development	266:286	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	2	6	from	diarrhea	320:327	arg1	protection					293:302	protection	293:302	protection from infectious diarrhea	293:327	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	2	6	from	diarrhea	320:327	arg1	causes					347:352	the major causes	337:352	the major causes of infant death worldwide	337:378	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	7	7	theme	agglutinin	996:1006	arg1	UEA					1011:1013	UEA	1011:1013	UEA	1011:1013	The sensor uses a lectin for affinity, specifically Ulex europaeus agglutinin I (UEA), with electrochemical readout.
34741182	7	7	theme	agglutinin	996:1006	arg1	I					1008:1008	agglutinin I	996:1008	Ulex europaeus agglutinin I (UEA)	981:1014	The sensor uses a lectin for affinity, specifically Ulex europaeus agglutinin I (UEA), with electrochemical readout.
34741182	11	8	theme	testing	1481:1487	arg1	assay					1489:1493	This bedside human milk testing assay	1457:1493	This bedside human milk testing assay	1457:1493	This bedside human milk testing assay enables POC, "sample-to-answer" quantitative HMO measurement, and will be a valuable tool to assess milk composition.
34741182	8	9	theme	spiked	1050:1055	arg1	studies					1057:1063	spiked studies	1050:1063	spiked studies	1050:1063	In spiked studies, the sensor exhibited a high degree of linearity (R2 = 0.991) over 0.5 to 3.0 μM with a 330-nM detection limit.
34741182	3	10	theme	infant	510:515	arg1	health					517:522	infant health	510:522	infant health	510:522	Due to genetic variation, the milk of some women (non-secretors) contains no or very little 2'FL with potential implications for infant health and development.
34741182	3	11	theme	potential	483:491	arg1	implications					493:504	potential implications	483:504	potential implications for infant health and development	483:538	Due to genetic variation, the milk of some women (non-secretors) contains no or very little 2'FL with potential implications for infant health and development.
34741182	2	12	theme	cognitive	266:274	arg1	development					276:286	cognitive development	266:286	cognitive development	266:286	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	4	13	from	concentration	611:623	arg1	milk					642:645	human milk	636:645	human milk	636:645	However, there is currently no technology to analyze the presence and concentration of HMOs in human milk at the point-of-care (POC).
34741182	5	14	theme	maternal-infant	780:794	arg1	health					796:801	maternal-infant health	780:801	maternal-infant health	780:801	The lack of such technology represents a major impediment to advancing human milk research and improving maternal-infant health.
34741182	11	15	theme	sample-to-answer	1509:1524	arg1	"					1525:1525	"sample-to-answer"	1508:1525	"sample-to-answer"	1508:1525	This bedside human milk testing assay enables POC, "sample-to-answer" quantitative HMO measurement, and will be a valuable tool to assess milk composition.
34741182	11	15	theme	sample-to-answer	1509:1524	arg1	POC					1503:1505	POC	1503:1505	POC	1503:1505	This bedside human milk testing assay enables POC, "sample-to-answer" quantitative HMO measurement, and will be a valuable tool to assess milk composition.
34741182	11	16	theme	POC	1503:1505	arg1	measurement					1544:1554	POC, "sample-to-answer" quantitative HMO measurement	1503:1554	POC, "sample-to-answer" quantitative HMO measurement	1503:1554	This bedside human milk testing assay enables POC, "sample-to-answer" quantitative HMO measurement, and will be a valuable tool to assess milk composition.
34741182	9	17	theme	secretor	1286:1293	arg1	samples					1312:1318	all secretor vs. non-secretor samples	1282:1318	all secretor vs. non-secretor samples	1282:1318	The sensor performance was clinically validated using banked human milk samples and correctly identified all secretor vs. non-secretor samples.
34741182	1	18	theme	HMO	182:184	arg1	composition					187:197	human milk oligosaccharide (HMO) composition	154:197	human milk oligosaccharide (HMO) composition	154:197	We present an electrochemical impedimetric-based biosensor for monitoring the variation in human milk oligosaccharide (HMO) composition.
34741182	5	19	theme	major	716:720	arg1	impediment					722:731	a major impediment	714:731	a major impediment to advancing human milk research and improving maternal-infant health	714:801	The lack of such technology represents a major impediment to advancing human milk research and improving maternal-infant health.
34741182	6	20	theme	unmet	817:821	arg1	need					823:826	this unmet need	812:826	this unmet need	812:826	Towards this unmet need, we report an impedimetric assay for HMOs with an α-1,2 linkage, the most abundant of which is 2'FL.
34741182	5	21	theme	technology	692:701	arg1	lack					679:682	The lack	675:682	The lack of such technology	675:701	The lack of such technology represents a major impediment to advancing human milk research and improving maternal-infant health.
34741182	1	22	from	variation	141:149	arg1	composition					187:197	human milk oligosaccharide (HMO) composition	154:197	human milk oligosaccharide (HMO) composition	154:197	We present an electrochemical impedimetric-based biosensor for monitoring the variation in human milk oligosaccharide (HMO) composition.
34741182	3	23	dep	no	455:456	arg1	FL					475:476	2'FL	473:476	2'FL with potential implications for infant health and development	473:538	Due to genetic variation, the milk of some women (non-secretors) contains no or very little 2'FL with potential implications for infant health and development.
34741182	4	24	from	presence	598:605	arg1	milk					642:645	human milk	636:645	human milk	636:645	However, there is currently no technology to analyze the presence and concentration of HMOs in human milk at the point-of-care (POC).
34741182	2	25	theme	death	364:368	arg1	worldwide					370:378	infant death worldwide	357:378	infant death worldwide	357:378	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	0	26	theme	human	14:18	arg1	milk					20:23	Point-of-care human milk	0:23	Point-of-care human milk	0:23	Point-of-care human milk testing for maternal secretor status.
34741182	3	27	contain	contains	446:453	arg1	milk					411:414	the milk	407:414	the milk of some women (non-secretors)	407:444	Due to genetic variation, the milk of some women (non-secretors) contains no or very little 2'FL with potential implications for infant health and development.
34741182	3	27	contain	contains	446:453	arg2	no					455:456	no	455:456	no	455:456	Due to genetic variation, the milk of some women (non-secretors) contains no or very little 2'FL with potential implications for infant health and development.
34741182	3	27	contain	contains	446:453	arg2	little					466:471	little	466:471	little	466:471	Due to genetic variation, the milk of some women (non-secretors) contains no or very little 2'FL with potential implications for infant health and development.
34741182	10	28	theme	HPLC	1438:1441	arg1	measurements					1443:1454	HPLC measurements	1438:1454	HPLC measurements	1438:1454	Furthermore, despite the short 35-min assay time and low sample volume (25 μL), the assay was highly correlated with HPLC measurements.
34741182	11	29	theme	human	1470:1474	arg1	assay					1489:1493	This bedside human milk testing assay	1457:1493	This bedside human milk testing assay	1457:1493	This bedside human milk testing assay enables POC, "sample-to-answer" quantitative HMO measurement, and will be a valuable tool to assess milk composition.
34741182	1	30	theme	electrochemical	77:91	arg1	biosensor					112:120	an electrochemical impedimetric-based biosensor	74:120	an electrochemical impedimetric-based biosensor for monitoring the variation in human milk oligosaccharide (HMO) composition	74:197	We present an electrochemical impedimetric-based biosensor for monitoring the variation in human milk oligosaccharide (HMO) composition.
34741182	10	31	theme	sample	1378:1383	arg1	25 μL					1393:1397	25 μL	1393:1397	25 μL	1393:1397	Furthermore, despite the short 35-min assay time and low sample volume (25 μL), the assay was highly correlated with HPLC measurements.
34741182	10	31	theme	sample	1378:1383	arg1	volume					1385:1390	low sample volume	1374:1390	low sample volume (25 μL)	1374:1398	Furthermore, despite the short 35-min assay time and low sample volume (25 μL), the assay was highly correlated with HPLC measurements.
34741182	2	32	theme	infant	357:362	arg1	worldwide					370:378	infant death worldwide	357:378	infant death worldwide	357:378	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	0	33	theme	Point-of-care	0:12	arg1	milk					20:23	Point-of-care human milk	0:23	Point-of-care human milk	0:23	Point-of-care human milk testing for maternal secretor status.
34741182	3	34	with	FL	475:476	arg1	implications					493:504	potential implications	483:504	potential implications for infant health and development	483:538	Due to genetic variation, the milk of some women (non-secretors) contains no or very little 2'FL with potential implications for infant health and development.
34741182	1	35	theme	impedimetric-based	93:110	arg1	biosensor					112:120	an electrochemical impedimetric-based biosensor	74:120	an electrochemical impedimetric-based biosensor for monitoring the variation in human milk oligosaccharide (HMO) composition	74:197	We present an electrochemical impedimetric-based biosensor for monitoring the variation in human milk oligosaccharide (HMO) composition.
34741182	8	36	theme	linearity	1104:1112	arg1	degree					1094:1099	a high degree	1087:1099	a high degree of linearity (R2 = 0.991)	1087:1125	In spiked studies, the sensor exhibited a high degree of linearity (R2 = 0.991) over 0.5 to 3.0 μM with a 330-nM detection limit.
34741182	7	37	theme	electrochemical	1022:1036	arg1	readout					1038:1044	electrochemical readout	1022:1044	electrochemical readout	1022:1044	The sensor uses a lectin for affinity, specifically Ulex europaeus agglutinin I (UEA), with electrochemical readout.
34741182	6	38	theme	linkage	884:890	arg1	abundant					902:909	abundant	902:909	abundant	902:909	Towards this unmet need, we report an impedimetric assay for HMOs with an α-1,2 linkage, the most abundant of which is 2'FL.
34741182	6	38	theme	linkage	884:890	arg1	FL					925:926	2'FL	923:926	2'FL	923:926	Towards this unmet need, we report an impedimetric assay for HMOs with an α-1,2 linkage, the most abundant of which is 2'FL.
34741182	7	39	dep	affinity	958:965	arg1	europaeus					986:994	Ulex europaeus agglutinin I (UEA)	981:1014	Ulex europaeus agglutinin I (UEA)	981:1014	The sensor uses a lectin for affinity, specifically Ulex europaeus agglutinin I (UEA), with electrochemical readout.
34741182	7	40	theme	Ulex	981:984	arg1	europaeus					986:994	Ulex europaeus agglutinin I (UEA)	981:1014	Ulex europaeus agglutinin I (UEA)	981:1014	The sensor uses a lectin for affinity, specifically Ulex europaeus agglutinin I (UEA), with electrochemical readout.
34741182	3	41	theme	women	424:428	arg1	milk					411:414	the milk	407:414	the milk of some women (non-secretors)	407:444	Due to genetic variation, the milk of some women (non-secretors) contains no or very little 2'FL with potential implications for infant health and development.
34741182	5	42	theme	human	746:750	arg1	research					757:764	human milk research	746:764	human milk research	746:764	The lack of such technology represents a major impediment to advancing human milk research and improving maternal-infant health.
34741182	6	43	theme	α-1,2	878:882	arg1	linkage					884:890	an α-1,2 linkage	875:890	an α-1,2 linkage	875:890	Towards this unmet need, we report an impedimetric assay for HMOs with an α-1,2 linkage, the most abundant of which is 2'FL.
34741182	10	44	theme	assay	1359:1363	arg1	time					1365:1368	the short 35-min assay time	1342:1368	the short 35-min assay time	1342:1368	Furthermore, despite the short 35-min assay time and low sample volume (25 μL), the assay was highly correlated with HPLC measurements.
34741182	11	45	theme	HMO	1540:1542	arg1	measurement					1544:1554	POC, "sample-to-answer" quantitative HMO measurement	1503:1554	POC, "sample-to-answer" quantitative HMO measurement	1503:1554	This bedside human milk testing assay enables POC, "sample-to-answer" quantitative HMO measurement, and will be a valuable tool to assess milk composition.
34741182	6	46	with	HMOs	865:868	arg1	linkage					884:890	an α-1,2 linkage	875:890	an α-1,2 linkage	875:890	Towards this unmet need, we report an impedimetric assay for HMOs with an α-1,2 linkage, the most abundant of which is 2'FL.
34741182	1	47	theme	human	154:158	arg1	composition					187:197	human milk oligosaccharide (HMO) composition	154:197	human milk oligosaccharide (HMO) composition	154:197	We present an electrochemical impedimetric-based biosensor for monitoring the variation in human milk oligosaccharide (HMO) composition.
34741182	0	48	theme	maternal	37:44	arg1	status					55:60	maternal secretor status	37:60	maternal secretor status	37:60	Point-of-care human milk testing for maternal secretor status.
34741182	10	49	theme	35-min	1352:1357	arg1	time					1365:1368	the short 35-min assay time	1342:1368	the short 35-min assay time	1342:1368	Furthermore, despite the short 35-min assay time and low sample volume (25 μL), the assay was highly correlated with HPLC measurements.
34741182	4	50	attach	presence	598:605	arg1	milk					642:645	human milk	636:645	human milk	636:645	However, there is currently no technology to analyze the presence and concentration of HMOs in human milk at the point-of-care (POC).
34741182	4	50	attach	presence	598:605	arg2	HMOs					628:631	HMOs	628:631	HMOs	628:631	However, there is currently no technology to analyze the presence and concentration of HMOs in human milk at the point-of-care (POC).
34741182	2	51	theme	worldwide	370:378	arg1	causes					347:352	the major causes	337:352	the major causes of infant death worldwide	337:378	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	3	52	theme	genetic	388:394	arg1	variation					396:404	genetic variation	388:404	genetic variation	388:404	Due to genetic variation, the milk of some women (non-secretors) contains no or very little 2'FL with potential implications for infant health and development.
34741182	10	53	theme	short	1346:1350	arg1	time					1365:1368	the short 35-min assay time	1342:1368	the short 35-min assay time	1342:1368	Furthermore, despite the short 35-min assay time and low sample volume (25 μL), the assay was highly correlated with HPLC measurements.
34741182	8	54	theme	high	1089:1092	arg1	degree					1094:1099	a high degree	1087:1099	a high degree of linearity (R2 = 0.991)	1087:1125	In spiked studies, the sensor exhibited a high degree of linearity (R2 = 0.991) over 0.5 to 3.0 μM with a 330-nM detection limit.
34741182	9	55	theme	sensor	1181:1186	arg1	performance					1188:1198	The sensor performance	1177:1198	The sensor performance	1177:1198	The sensor performance was clinically validated using banked human milk samples and correctly identified all secretor vs. non-secretor samples.
34741182	7	56	with	europaeus	986:994	arg1	readout					1038:1044	electrochemical readout	1022:1044	electrochemical readout	1022:1044	The sensor uses a lectin for affinity, specifically Ulex europaeus agglutinin I (UEA), with electrochemical readout.
34741182	8	57	theme	330-nM	1153:1158	arg1	limit					1170:1174	a 330-nM detection limit	1151:1174	a 330-nM detection limit	1151:1174	In spiked studies, the sensor exhibited a high degree of linearity (R2 = 0.991) over 0.5 to 3.0 μM with a 330-nM detection limit.
34741182	0	58	theme	secretor	46:53	arg1	status					55:60	maternal secretor status	37:60	maternal secretor status	37:60	Point-of-care human milk testing for maternal secretor status.
34741182	11	59	theme	milk	1595:1598	arg1	composition					1600:1610	milk composition	1595:1610	milk composition	1595:1610	This bedside human milk testing assay enables POC, "sample-to-answer" quantitative HMO measurement, and will be a valuable tool to assess milk composition.
34741182	8	60	dep	3.0 μM	1139:1144	arg1	to					1136:1137	to	1136:1137	to	1136:1137	In spiked studies, the sensor exhibited a high degree of linearity (R2 = 0.991) over 0.5 to 3.0 μM with a 330-nM detection limit.
34741182	1	61	theme	milk	160:163	arg1	composition					187:197	human milk oligosaccharide (HMO) composition	154:197	human milk oligosaccharide (HMO) composition	154:197	We present an electrochemical impedimetric-based biosensor for monitoring the variation in human milk oligosaccharide (HMO) composition.
34741182	9	62	theme	banked	1231:1236	arg1	samples					1249:1255	banked human milk samples	1231:1255	banked human milk samples	1231:1255	The sensor performance was clinically validated using banked human milk samples and correctly identified all secretor vs. non-secretor samples.
34741182	10	63	theme	low	1374:1376	arg1	25 μL					1393:1397	25 μL	1393:1397	25 μL	1393:1397	Furthermore, despite the short 35-min assay time and low sample volume (25 μL), the assay was highly correlated with HPLC measurements.
34741182	10	63	theme	low	1374:1376	arg1	volume					1385:1390	low sample volume	1374:1390	low sample volume (25 μL)	1374:1398	Furthermore, despite the short 35-min assay time and low sample volume (25 μL), the assay was highly correlated with HPLC measurements.
34741182	2	64	theme	infant	251:256	arg1	growth					258:263	infant growth	251:263	infant growth	251:263	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	9	65	theme	human	1238:1242	arg1	samples					1249:1255	banked human milk samples	1231:1255	banked human milk samples	1231:1255	The sensor performance was clinically validated using banked human milk samples and correctly identified all secretor vs. non-secretor samples.
34741182	8	66	theme	detection	1160:1168	arg1	limit					1170:1174	a 330-nM detection limit	1151:1174	a 330-nM detection limit	1151:1174	In spiked studies, the sensor exhibited a high degree of linearity (R2 = 0.991) over 0.5 to 3.0 μM with a 330-nM detection limit.
34741182	11	67	theme	bedside	1462:1468	arg1	assay					1489:1493	This bedside human milk testing assay	1457:1493	This bedside human milk testing assay	1457:1493	This bedside human milk testing assay enables POC, "sample-to-answer" quantitative HMO measurement, and will be a valuable tool to assess milk composition.
34741182	2	68	theme	infectious	309:318	arg1	diarrhea					320:327	infectious diarrhea	309:327	infectious diarrhea	309:327	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	9	69	theme	milk	1244:1247	arg1	samples					1249:1255	banked human milk samples	1231:1255	banked human milk samples	1231:1255	The sensor performance was clinically validated using banked human milk samples and correctly identified all secretor vs. non-secretor samples.
34741182	4	70	dep	presence	598:605	arg1	the					594:596	the	594:596	the	594:596	However, there is currently no technology to analyze the presence and concentration of HMOs in human milk at the point-of-care (POC).
34741182	5	71	theme	milk	752:755	arg1	research					757:764	human milk research	746:764	human milk research	746:764	The lack of such technology represents a major impediment to advancing human milk research and improving maternal-infant health.
34741182	2	72	theme	causes	347:352	arg1	one					330:332	one	330:332	one	330:332	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	2	72	theme	causes	347:352	arg1	protection					293:302	protection	293:302	protection from infectious diarrhea	293:327	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	2	72	theme	causes	347:352	arg1	causes					347:352	the major causes	337:352	the major causes of infant death worldwide	337:378	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	9	73	theme	non-secretor	1299:1310	arg1	samples					1312:1318	all secretor vs. non-secretor samples	1282:1318	all secretor vs. non-secretor samples	1282:1318	The sensor performance was clinically validated using banked human milk samples and correctly identified all secretor vs. non-secretor samples.
34741182	6	74	theme	impedimetric	842:853	arg1	assay					855:859	an impedimetric assay	839:859	an impedimetric assay for HMOs with an α-1,2 linkage, the most abundant of which is 2'FL	839:926	Towards this unmet need, we report an impedimetric assay for HMOs with an α-1,2 linkage, the most abundant of which is 2'FL.
34741182	2	75	theme	major	341:345	arg1	causes					347:352	the major causes	337:352	the major causes of infant death worldwide	337:378	2'-Fucosyllactose (2'FL) is an HMO associated with infant growth, cognitive development, and protection from infectious diarrhea, one of the major causes of infant death worldwide.
34741182	11	76	theme	quantitative	1527:1538	arg1	measurement					1544:1554	POC, "sample-to-answer" quantitative HMO measurement	1503:1554	POC, "sample-to-answer" quantitative HMO measurement	1503:1554	This bedside human milk testing assay enables POC, "sample-to-answer" quantitative HMO measurement, and will be a valuable tool to assess milk composition.
34741182	11	77	theme	valuable	1571:1578	arg1	tool					1580:1583	a valuable tool	1569:1583	a valuable tool to assess milk composition	1569:1610	This bedside human milk testing assay enables POC, "sample-to-answer" quantitative HMO measurement, and will be a valuable tool to assess milk composition.
34534578	0	0	theme	composite	111:119	arg1	sponges					121:127	quaternized cellulose‑sodium alginate composite sponges	73:127	quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing	73:157	Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing.
34534578	4	1	theme	quaternary	924:933	arg1	group					944:948	quaternary ammonium group	924:948	quaternary ammonium group	924:948	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	2	2	theme	anti-inflammatory	383:399	arg1	properties					401:410	antibacterial and anti-inflammatory properties	365:410	antibacterial and anti-inflammatory properties	365:410	Herein, a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties based on quaternized cellulose (QC), sodium alginate (SA) and Zn2+ was reported.
34534578	0	3	theme	alginate	102:109	arg1	sponges					121:127	quaternized cellulose‑sodium alginate composite sponges	73:127	quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing	73:157	Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing.
34534578	3	4	theme	interactions	519:530	arg1	existence					497:505	The existence	493:505	The existence of physical interactions, such as electrostatic interaction, chelation and hydrogen bonding	493:597	The existence of physical interactions, such as electrostatic interaction, chelation and hydrogen bonding endowed the sponges with enhanced mechanical property.
34534578	3	5	with	endowed	599:605	arg1	property					644:651	enhanced mechanical property	624:651	enhanced mechanical property	624:651	The existence of physical interactions, such as electrostatic interaction, chelation and hydrogen bonding endowed the sponges with enhanced mechanical property.
34534578	4	6	theme	group	944:948	arg1	effects					889:895	the synergistic effects	873:895	the synergistic effects of steady Zn2+ release and quaternary ammonium group	873:948	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	3	7	theme	interaction	555:565	arg1	existence					497:505	The existence	493:505	The existence of physical interactions, such as electrostatic interaction, chelation and hydrogen bonding	493:597	The existence of physical interactions, such as electrostatic interaction, chelation and hydrogen bonding endowed the sponges with enhanced mechanical property.
34534578	4	8	theme	physical	791:798	arg1	cross-linking					800:812	physical cross-linking	791:812	physical cross-linking	791:812	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	5	9	theme	antibacterial	1001:1013	arg1	effect					1037:1042	the enhanced antibacterial and anti-inflammatory effect	988:1042	the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration	988:1238	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	4	10	theme	ammonium	935:942	arg1	group					944:948	quaternary ammonium group	924:948	quaternary ammonium group	924:948	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	3	11	theme	physical	510:517	arg1	interactions					519:530	physical interactions	510:530	physical interactions	510:530	The existence of physical interactions, such as electrostatic interaction, chelation and hydrogen bonding endowed the sponges with enhanced mechanical property.
34534578	1	12	theme	healing	295:301	arg1	process					303:309	the healing process	291:309	the healing process	291:309	Bacterial infection has become one of the most challenges for wound healing, which causes serious inflammatory response and delays the healing process.
34534578	0	13	theme	wound	145:149	arg1	healing					151:157	accelerated wound healing	133:157	accelerated wound healing	133:157	Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing.
34534578	4	14	theme	steady	900:905	arg1	release					912:918	steady Zn2+ release	900:918	steady Zn2+ release	900:918	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	5	15	theme	sponges	1051:1057	arg1	effect					1037:1042	the enhanced antibacterial and anti-inflammatory effect	988:1042	the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration	988:1238	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	2	16	theme	quaternized	421:431	arg1	cellulose					433:441	quaternized cellulose	421:441	quaternized cellulose (QC)	421:446	Herein, a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties based on quaternized cellulose (QC), sodium alginate (SA) and Zn2+ was reported.
34534578	2	16	theme	quaternized	421:431	arg1	QC					444:445	QC	444:445	QC	444:445	Herein, a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties based on quaternized cellulose (QC), sodium alginate (SA) and Zn2+ was reported.
34534578	0	17	theme	accelerated	133:143	arg1	healing					151:157	accelerated wound healing	133:157	accelerated wound healing	133:157	Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing.
34534578	5	18	theme	mitigating	1198:1207	arg1	infiltration					1227:1238	mitigating inflammatory cell infiltration	1198:1238	mitigating inflammatory cell infiltration	1198:1238	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	4	19	theme	composite	658:666	arg1	sponges					668:674	The composite sponges	654:674	The composite sponges	654:674	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	1	20	theme	serious	250:256	arg1	response					271:278	serious inflammatory response	250:278	serious inflammatory response	250:278	Bacterial infection has become one of the most challenges for wound healing, which causes serious inflammatory response and delays the healing process.
34534578	1	21	theme	most	202:205	arg1	challenges					207:216	the most challenges	198:216	the most challenges	198:216	Bacterial infection has become one of the most challenges for wound healing, which causes serious inflammatory response and delays the healing process.
34534578	5	22	theme	inflammatory	1209:1220	arg1	infiltration					1227:1238	mitigating inflammatory cell infiltration	1198:1238	mitigating inflammatory cell infiltration	1198:1238	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	4	23	theme	release	912:918	arg1	effects					889:895	the synergistic effects	873:895	the synergistic effects of steady Zn2+ release and quaternary ammonium group	873:948	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	3	24	theme	hydrogen	582:589	arg1	bonding					591:597	hydrogen bonding	582:597	hydrogen bonding	582:597	The existence of physical interactions, such as electrostatic interaction, chelation and hydrogen bonding endowed the sponges with enhanced mechanical property.
34534578	6	25	from	potentials	1286:1295	arg1	management					1326:1335	bacteria-associated wound management	1300:1335	bacteria-associated wound management	1300:1335	Overall, the novel sponge demonstrated great potentials in bacteria-associated wound management.
34534578	1	26	theme	challenges	207:216	arg1	challenges					207:216	the most challenges	198:216	the most challenges	198:216	Bacterial infection has become one of the most challenges for wound healing, which causes serious inflammatory response and delays the healing process.
34534578	1	26	theme	challenges	207:216	arg1	one					191:193	one	191:193	one	191:193	Bacterial infection has become one of the most challenges for wound healing, which causes serious inflammatory response and delays the healing process.
34534578	0	27	theme	Biocompatible	0:12	arg1	ion					56:58	Biocompatible, antibacterial and anti-inflammatory zinc ion	0:58	Biocompatible, antibacterial and anti-inflammatory zinc ion	0:58	Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing.
34534578	6	28	theme	wound	1320:1324	arg1	management					1326:1335	bacteria-associated wound management	1300:1335	bacteria-associated wound management	1300:1335	Overall, the novel sponge demonstrated great potentials in bacteria-associated wound management.
34534578	4	29	theme	Zn2+	907:910	arg1	release					912:918	steady Zn2+ release	900:918	steady Zn2+ release	900:918	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	4	30	theme	component	777:785	arg1	nature					763:768	the compatible nature	748:768	the compatible nature of the component and physical cross-linking	748:812	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	5	31	dep	In	951:952	arg1	vivo					954:957	vivo	954:957	vivo	954:957	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	5	32	theme	enhanced	992:999	arg1	effect					1037:1042	the enhanced antibacterial and anti-inflammatory effect	988:1042	the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration	988:1238	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	2	33	theme	novel	322:326	arg1	sponge					328:333	a novel sponge	320:333	a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties based on quaternized cellulose (QC), sodium alginate (SA) and Zn2+	320:477	Herein, a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties based on quaternized cellulose (QC), sodium alginate (SA) and Zn2+ was reported.
34534578	2	34	theme	sodium	449:454	arg1	SA					466:467	SA	466:467	SA	466:467	Herein, a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties based on quaternized cellulose (QC), sodium alginate (SA) and Zn2+ was reported.
34534578	2	34	theme	sodium	449:454	arg1	alginate					456:463	sodium alginate	449:463	sodium alginate (SA)	449:468	Herein, a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties based on quaternized cellulose (QC), sodium alginate (SA) and Zn2+ was reported.
34534578	6	35	theme	novel	1254:1258	arg1	sponge					1260:1265	the novel sponge	1250:1265	the novel sponge	1250:1265	Overall, the novel sponge demonstrated great potentials in bacteria-associated wound management.
34534578	5	36	dep	validated	973:981	arg1	effect					1037:1042	the enhanced antibacterial and anti-inflammatory effect	988:1042	the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration	988:1238	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	5	37	theme	epithelial	1149:1158	arg1	regeneration					1160:1171	epithelial regeneration	1149:1171	epithelial regeneration	1149:1171	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	3	38	dep	such	533:536	arg1	as					538:539	as	538:539	as	538:539	The existence of physical interactions, such as electrostatic interaction, chelation and hydrogen bonding endowed the sponges with enhanced mechanical property.
34534578	0	39	theme	zinc	51:54	arg1	ion					56:58	Biocompatible, antibacterial and anti-inflammatory zinc ion	0:58	Biocompatible, antibacterial and anti-inflammatory zinc ion	0:58	Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing.
34534578	4	40	theme	hemostatic	719:728	arg1	efficiency					730:739	hemostatic efficiency	719:739	hemostatic efficiency	719:739	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	5	41	theme	wound	1089:1093	arg1	closure					1095:1101	wound closure	1089:1101	wound closure	1089:1101	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	6	42	theme	bacteria-associated	1300:1318	arg1	management					1326:1335	bacteria-associated wound management	1300:1335	bacteria-associated wound management	1300:1335	Overall, the novel sponge demonstrated great potentials in bacteria-associated wound management.
34534578	2	43	with	sponge	328:333	arg1	properties					401:410	antibacterial and anti-inflammatory properties	365:410	antibacterial and anti-inflammatory properties	365:410	Herein, a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties based on quaternized cellulose (QC), sodium alginate (SA) and Zn2+ was reported.
34534578	5	44	theme	collagen	1174:1181	arg1	deposition					1183:1192	collagen deposition	1174:1192	collagen deposition	1174:1192	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	2	45	theme	antibacterial	365:377	arg1	properties					401:410	antibacterial and anti-inflammatory properties	365:410	antibacterial and anti-inflammatory properties	365:410	Herein, a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties based on quaternized cellulose (QC), sodium alginate (SA) and Zn2+ was reported.
34534578	5	46	theme	anti-inflammatory	1019:1035	arg1	effect					1037:1042	the enhanced antibacterial and anti-inflammatory effect	988:1042	the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration	988:1238	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	4	47	theme	synergistic	877:887	arg1	effects					889:895	the synergistic effects	873:895	the synergistic effects of steady Zn2+ release and quaternary ammonium group	873:948	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	4	48	theme	compatible	752:761	arg1	nature					763:768	the compatible nature	748:768	the compatible nature of the component and physical cross-linking	748:812	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	3	49	theme	mechanical	633:642	arg1	property					644:651	enhanced mechanical property	624:651	enhanced mechanical property	624:651	The existence of physical interactions, such as electrostatic interaction, chelation and hydrogen bonding endowed the sponges with enhanced mechanical property.
34534578	5	50	theme	skin	1129:1132	arg1	tissue					1134:1139	skin tissue	1129:1139	skin tissue	1129:1139	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	4	51	theme	antibacterial	835:847	arg1	property					849:856	superior antibacterial property	826:856	superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group	826:948	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	1	52	theme	Bacterial	160:168	arg1	infection					170:178	Bacterial infection	160:178	Bacterial infection	160:178	Bacterial infection has become one of the most challenges for wound healing, which causes serious inflammatory response and delays the healing process.
34534578	4	53	theme	cross-linking	800:812	arg1	nature					763:768	the compatible nature	748:768	the compatible nature of the component and physical cross-linking	748:812	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	3	54	theme	electrostatic	541:553	arg1	interaction					555:565	electrostatic interaction	541:565	electrostatic interaction	541:565	The existence of physical interactions, such as electrostatic interaction, chelation and hydrogen bonding endowed the sponges with enhanced mechanical property.
34534578	5	55	theme	tissue	1134:1139	arg1	closure					1095:1101	wound closure	1089:1101	wound closure	1089:1101	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	5	55	theme	tissue	1134:1139	arg1	reconstruction					1111:1124	the reconstruction	1107:1124	the reconstruction of skin tissue	1107:1139	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	4	56	theme	superior	826:833	arg1	property					849:856	superior antibacterial property	826:856	superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group	826:948	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	6	57	theme	great	1280:1284	arg1	potentials					1286:1295	great potentials	1280:1295	great potentials in bacteria-associated wound management	1280:1335	Overall, the novel sponge demonstrated great potentials in bacteria-associated wound management.
34534578	2	58	theme	excellent	340:348	arg1	properties					401:410	antibacterial and anti-inflammatory properties	365:410	antibacterial and anti-inflammatory properties	365:410	Herein, a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties based on quaternized cellulose (QC), sodium alginate (SA) and Zn2+ was reported.
34534578	2	59	theme	biocompatible	350:362	arg1	properties					401:410	antibacterial and anti-inflammatory properties	365:410	antibacterial and anti-inflammatory properties	365:410	Herein, a novel sponge with excellent biocompatible, antibacterial and anti-inflammatory properties based on quaternized cellulose (QC), sodium alginate (SA) and Zn2+ was reported.
34534578	0	60	theme	cellulose‑sodium	85:100	arg1	sponges					121:127	quaternized cellulose‑sodium alginate composite sponges	73:127	quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing	73:157	Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing.
34534578	3	61	theme	enhanced	624:631	arg1	property					644:651	enhanced mechanical property	624:651	enhanced mechanical property	624:651	The existence of physical interactions, such as electrostatic interaction, chelation and hydrogen bonding endowed the sponges with enhanced mechanical property.
34534578	1	62	theme	wound	222:226	arg1	healing					228:234	wound healing	222:234	wound healing	222:234	Bacterial infection has become one of the most challenges for wound healing, which causes serious inflammatory response and delays the healing process.
34534578	4	63	theme	outstanding	686:696	arg1	biocompatibility					698:713	outstanding biocompatibility	686:713	outstanding biocompatibility	686:713	The composite sponges exhibited outstanding biocompatibility and hemostatic efficiency due to the compatible nature of the component and physical cross-linking, as well as superior antibacterial property benefited from the synergistic effects of steady Zn2+ release and quaternary ammonium group.
34534578	1	64	theme	inflammatory	258:269	arg1	response					271:278	serious inflammatory response	250:278	serious inflammatory response	250:278	Bacterial infection has become one of the most challenges for wound healing, which causes serious inflammatory response and delays the healing process.
34534578	0	65	theme	quaternized	73:83	arg1	sponges					121:127	quaternized cellulose‑sodium alginate composite sponges	73:127	quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing	73:157	Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing.
34534578	5	66	theme	cell	1222:1225	arg1	infiltration					1227:1238	mitigating inflammatory cell infiltration	1198:1238	mitigating inflammatory cell infiltration	1198:1238	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34534578	0	67	dep	Biocompatible	0:12	arg1	antibacterial					15:27	antibacterial	15:27	antibacterial	15:27	Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing.
34534578	0	67	dep	Biocompatible	0:12	arg1	anti-inflammatory					33:49	anti-inflammatory	33:49	anti-inflammatory	33:49	Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing.
34534578	5	68	theme	In	951:952	arg1	investigation					959:971	In vivo investigation	951:971	In vivo investigation	951:971	In vivo investigation validated that the enhanced antibacterial and anti-inflammatory effect of the sponges, which significantly promoted wound closure and the reconstruction of skin tissue through epithelial regeneration, collagen deposition and mitigating inflammatory cell infiltration.
34713756	0	0	theme	case	59:62	arg1	study					64:68	A case study	57:68	Potential for the valorisation of brewer's spent grains: A case study for the sequential extraction of saccharides and lignin.	0:125	Potential for the valorisation of brewer's spent grains: A case study for the sequential extraction of saccharides and lignin.
34713756	3	1	theme	23	616:617	arg1	%					611:611	%	611:611	%	611:611	In particular, the protein content can vary from 13wt% to 23wt%, which is accompanied by a change in the hemicelluloses content from 9% to 23% (in the samples of our study).
34713756	7	2	theme	purity	965:970	arg1	lignin					972:977	a high purity lignin	958:977	a high purity lignin	958:977	Cellulose could be isolated at more than 68%, while a high purity lignin could be recovered from a lignin-rich fraction (70wt%).
34713756	3	3	theme	9	610:610	arg1	%					611:611	%	611:611	%	611:611	In particular, the protein content can vary from 13wt% to 23wt%, which is accompanied by a change in the hemicelluloses content from 9% to 23% (in the samples of our study).
34713756	1	4	theme	successive	205:214	arg1	extraction					216:225	the successive extraction	201:225	the successive extraction of the main lignocellulosic biopolymers, namely, cellulose, hemicelluloses and lignin	201:311	This study highlights the possibility of using brewers' grains (BSGs) for the successive extraction of the main lignocellulosic biopolymers, namely, cellulose, hemicelluloses and lignin.
34713756	3	5	theme	protein	496:502	arg1	content					504:510	the protein content	492:510	the protein content	492:510	In particular, the protein content can vary from 13wt% to 23wt%, which is accompanied by a change in the hemicelluloses content from 9% to 23% (in the samples of our study).
34713756	9	6	theme	composition	1320:1330	arg1	prerequisite					1347:1358	a prerequisite	1345:1358	a prerequisite for an efficient extraction process	1345:1394	The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process.
34713756	9	6	theme	composition	1320:1330	arg1	analysis					1304:1311	the preliminary chemical analysis	1279:1311	the preliminary chemical analysis of the composition	1279:1330	The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process.
34713756	6	7	theme	fixed	792:796	arg1	time					807:810	fixed reaction time	792:810	fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses	792:884	NaOH) at a temperature of 120°C and fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses could be recovered.
34713756	8	8	theme	composition	1095:1105	arg1	hindrance					1126:1134	a hindrance	1124:1134	a hindrance to achieving process standardisation and large-scale exploitation	1124:1200	Our work also suggests that the variability of the chemical composition of these BSGs is a hindrance to achieving process standardisation and large-scale exploitation.
34713756	8	8	theme	composition	1095:1105	arg1	variability					1067:1077	the variability	1063:1077	the variability of the chemical composition of these BSGs	1063:1119	Our work also suggests that the variability of the chemical composition of these BSGs is a hindrance to achieving process standardisation and large-scale exploitation.
34713756	0	9	theme	sequential	78:87	arg1	extraction					89:98	the sequential extraction	74:98	the sequential extraction of saccharides and lignin	74:124	Potential for the valorisation of brewer's spent grains: A case study for the sequential extraction of saccharides and lignin.
34713756	9	10	theme	preliminary	1283:1293	arg1	prerequisite					1347:1358	a prerequisite	1345:1358	a prerequisite for an efficient extraction process	1345:1394	The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process.
34713756	9	10	theme	preliminary	1283:1293	arg1	analysis					1304:1311	the preliminary chemical analysis	1279:1311	the preliminary chemical analysis of the composition	1279:1330	The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process.
34713756	0	11	theme	Potential	0:8	arg1	grains					49:54	Potential for the valorisation of brewer's spent grains	0:54	Potential for the valorisation of brewer's spent grains: A case study for the sequential extraction of saccharides and lignin.	0:125	Potential for the valorisation of brewer's spent grains: A case study for the sequential extraction of saccharides and lignin.
34713756	3	12	from	change	568:573	arg1	samples					628:634	the samples	624:634	the samples of our study	624:647	In particular, the protein content can vary from 13wt% to 23wt%, which is accompanied by a change in the hemicelluloses content from 9% to 23% (in the samples of our study).
34713756	3	12	from	change	568:573	arg1	content					597:603	the hemicelluloses content	578:603	the hemicelluloses content from 9% to 23%	578:618	In particular, the protein content can vary from 13wt% to 23wt%, which is accompanied by a change in the hemicelluloses content from 9% to 23% (in the samples of our study).
34713756	3	12	from	change	568:573	arg1	%					618:618	9% to 23%	610:618	9% to 23%	610:618	In particular, the protein content can vary from 13wt% to 23wt%, which is accompanied by a change in the hemicelluloses content from 9% to 23% (in the samples of our study).
34713756	3	13	from	%	618:618	arg1	change					568:573	a change	566:573	a change in the hemicelluloses content from 9% to 23% (in the samples of our study)	566:648	In particular, the protein content can vary from 13wt% to 23wt%, which is accompanied by a change in the hemicelluloses content from 9% to 23% (in the samples of our study).
34713756	3	13	from	%	618:618	arg1	content					597:603	the hemicelluloses content	578:603	the hemicelluloses content from 9% to 23%	578:618	In particular, the protein content can vary from 13wt% to 23wt%, which is accompanied by a change in the hemicelluloses content from 9% to 23% (in the samples of our study).
34713756	5	14	dep	base	739:742	arg1	w/v					748:750	3% w/v	745:750	3% w/v	745:750	H2SO4) and a base (3% w/v aq.
34713756	2	15	theme	BSGs	415:418	arg1	batches					404:410	distinct batches	395:410	distinct batches of BSGs	395:418	An exhaustive chemical characterisation revealed a variability of composition in distinct batches of BSGs, depending on their origin and the brewing process used.
34713756	6	16	theme	120°C	782:786	arg1	temperature					767:777	a temperature	765:777	a temperature of 120°C	765:786	NaOH) at a temperature of 120°C and fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses could be recovered.
34713756	4	17	theme	%	716:716	arg1	v/v					718:720	1.25% v/v aq	712:723	1.25% v/v aq	712:723	By applying a two-step aqueous treatment, involving an acid (1.25% v/v aq.
34713756	8	18	theme	chemical	1086:1093	arg1	composition					1095:1105	the chemical composition	1082:1105	the chemical composition of these BSGs	1082:1119	Our work also suggests that the variability of the chemical composition of these BSGs is a hindrance to achieving process standardisation and large-scale exploitation.
34713756	3	19	dep	%	539:539	arg1	to					532:533	to	532:533	to	532:533	In particular, the protein content can vary from 13wt% to 23wt%, which is accompanied by a change in the hemicelluloses content from 9% to 23% (in the samples of our study).
34713756	1	20	theme	main	234:237	arg1	biopolymers					255:265	the main lignocellulosic biopolymers	230:265	the main lignocellulosic biopolymers	230:265	This study highlights the possibility of using brewers' grains (BSGs) for the successive extraction of the main lignocellulosic biopolymers, namely, cellulose, hemicelluloses and lignin.
34713756	1	20	theme	main	234:237	arg1	lignin					306:311	lignin	306:311	lignin	306:311	This study highlights the possibility of using brewers' grains (BSGs) for the successive extraction of the main lignocellulosic biopolymers, namely, cellulose, hemicelluloses and lignin.
34713756	1	20	theme	main	234:237	arg1	hemicelluloses					287:300	hemicelluloses	287:300	hemicelluloses	287:300	This study highlights the possibility of using brewers' grains (BSGs) for the successive extraction of the main lignocellulosic biopolymers, namely, cellulose, hemicelluloses and lignin.
34713756	1	20	theme	main	234:237	arg1	cellulose					276:284	cellulose	276:284	cellulose	276:284	This study highlights the possibility of using brewers' grains (BSGs) for the successive extraction of the main lignocellulosic biopolymers, namely, cellulose, hemicelluloses and lignin.
34713756	6	21	from	temperature	767:777	arg1	time					807:810	fixed reaction time	792:810	fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses	792:884	NaOH) at a temperature of 120°C and fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses could be recovered.
34713756	6	21	from	temperature	767:777	arg1	NaOH					756:759	NaOH)	756:760	NaOH) at a temperature of 120°C	756:786	NaOH) at a temperature of 120°C and fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses could be recovered.
34713756	2	22	theme	distinct	395:402	arg1	batches					404:410	distinct batches	395:410	distinct batches of BSGs	395:418	An exhaustive chemical characterisation revealed a variability of composition in distinct batches of BSGs, depending on their origin and the brewing process used.
34713756	1	23	theme	lignocellulosic	239:253	arg1	biopolymers					255:265	the main lignocellulosic biopolymers	230:265	the main lignocellulosic biopolymers	230:265	This study highlights the possibility of using brewers' grains (BSGs) for the successive extraction of the main lignocellulosic biopolymers, namely, cellulose, hemicelluloses and lignin.
34713756	1	23	theme	lignocellulosic	239:253	arg1	lignin					306:311	lignin	306:311	lignin	306:311	This study highlights the possibility of using brewers' grains (BSGs) for the successive extraction of the main lignocellulosic biopolymers, namely, cellulose, hemicelluloses and lignin.
34713756	1	23	theme	lignocellulosic	239:253	arg1	hemicelluloses					287:300	hemicelluloses	287:300	hemicelluloses	287:300	This study highlights the possibility of using brewers' grains (BSGs) for the successive extraction of the main lignocellulosic biopolymers, namely, cellulose, hemicelluloses and lignin.
34713756	1	23	theme	lignocellulosic	239:253	arg1	cellulose					276:284	cellulose	276:284	cellulose	276:284	This study highlights the possibility of using brewers' grains (BSGs) for the successive extraction of the main lignocellulosic biopolymers, namely, cellulose, hemicelluloses and lignin.
34713756	8	24	theme	large-scale	1177:1187	arg1	exploitation					1189:1200	large-scale exploitation	1177:1200	large-scale exploitation	1177:1200	Our work also suggests that the variability of the chemical composition of these BSGs is a hindrance to achieving process standardisation and large-scale exploitation.
34713756	0	25	dep	grains	49:54	arg1	study					64:68	A case study	57:68	Potential for the valorisation of brewer's spent grains: A case study for the sequential extraction of saccharides and lignin.	0:125	Potential for the valorisation of brewer's spent grains: A case study for the sequential extraction of saccharides and lignin.
34713756	6	26	theme	hemicelluloses	871:884	arg1	hemicelluloses					871:884	hemicelluloses	871:884	hemicelluloses	871:884	NaOH) at a temperature of 120°C and fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses could be recovered.
34713756	6	26	theme	hemicelluloses	871:884	arg1	%					866:866	more than 80%	854:866	more than 80% of hemicelluloses	854:884	NaOH) at a temperature of 120°C and fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses could be recovered.
34713756	6	26	theme	hemicelluloses	871:884	arg1	minutes					829:835	minutes	829:835	minutes (15-90 minutes)	829:851	NaOH) at a temperature of 120°C and fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses could be recovered.
34713756	1	27	theme	biopolymers	255:265	arg1	extraction					216:225	the successive extraction	201:225	the successive extraction of the main lignocellulosic biopolymers, namely, cellulose, hemicelluloses and lignin	201:311	This study highlights the possibility of using brewers' grains (BSGs) for the successive extraction of the main lignocellulosic biopolymers, namely, cellulose, hemicelluloses and lignin.
34713756	6	28	theme	minutes	829:835	arg1	tens					821:824	a few tens	815:824	a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses	815:884	NaOH) at a temperature of 120°C and fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses could be recovered.
34713756	2	29	theme	composition	380:390	arg1	variability					365:375	a variability	363:375	a variability of composition in distinct batches of BSGs	363:418	An exhaustive chemical characterisation revealed a variability of composition in distinct batches of BSGs, depending on their origin and the brewing process used.
34713756	7	30	theme	high	960:963	arg1	lignin					972:977	a high purity lignin	958:977	a high purity lignin	958:977	Cellulose could be isolated at more than 68%, while a high purity lignin could be recovered from a lignin-rich fraction (70wt%).
34713756	0	31	theme	saccharides	103:113	arg1	extraction					89:98	the sequential extraction	74:98	the sequential extraction of saccharides and lignin	74:124	Potential for the valorisation of brewer's spent grains: A case study for the sequential extraction of saccharides and lignin.
34713756	6	32	theme	reaction	798:805	arg1	time					807:810	fixed reaction time	792:810	fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses	792:884	NaOH) at a temperature of 120°C and fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses could be recovered.
34713756	8	33	theme	BSGs	1116:1119	arg1	composition					1095:1105	the chemical composition	1082:1105	the chemical composition of these BSGs	1082:1119	Our work also suggests that the variability of the chemical composition of these BSGs is a hindrance to achieving process standardisation and large-scale exploitation.
34713756	9	34	theme	various	1218:1224	arg1	materials					1226:1234	various materials	1218:1234	various materials	1218:1234	The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process.
34713756	0	35	theme	spent	43:47	arg1	valorisation					18:29	the valorisation	14:29	the valorisation of brewer's spent	14:47	Potential for the valorisation of brewer's spent grains: A case study for the sequential extraction of saccharides and lignin.
34713756	3	36	theme	study	643:647	arg1	samples					628:634	the samples	624:634	the samples of our study	624:647	In particular, the protein content can vary from 13wt% to 23wt%, which is accompanied by a change in the hemicelluloses content from 9% to 23% (in the samples of our study).
34713756	3	37	theme	%	530:530	arg1	%					539:539	13wt% to 23wt%	526:539	13wt% to 23wt%	526:539	In particular, the protein content can vary from 13wt% to 23wt%, which is accompanied by a change in the hemicelluloses content from 9% to 23% (in the samples of our study).
34713756	9	38	theme	materials	1226:1234	arg1	pooling					1207:1213	The pooling	1203:1213	The pooling of various materials	1203:1234	The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process.
34713756	9	38	theme	materials	1226:1234	arg1	option					1267:1272	a recommended option	1253:1272	a recommended option	1253:1272	The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process.
34713756	0	39	theme	lignin	119:124	arg1	extraction					89:98	the sequential extraction	74:98	the sequential extraction of saccharides and lignin	74:124	Potential for the valorisation of brewer's spent grains: A case study for the sequential extraction of saccharides and lignin.
34713756	2	40	from	variability	365:375	arg1	batches					404:410	distinct batches	395:410	distinct batches of BSGs	395:418	An exhaustive chemical characterisation revealed a variability of composition in distinct batches of BSGs, depending on their origin and the brewing process used.
34713756	5	41	theme	%	746:746	arg1	w/v					748:750	3% w/v	745:750	3% w/v	745:750	H2SO4) and a base (3% w/v aq.
34713756	8	42	theme	process	1149:1155	arg1	standardisation					1157:1171	process standardisation	1149:1171	process standardisation	1149:1171	Our work also suggests that the variability of the chemical composition of these BSGs is a hindrance to achieving process standardisation and large-scale exploitation.
34713756	4	43	theme	two-step	665:672	arg1	treatment					682:690	a two-step aqueous treatment	663:690	a two-step aqueous treatment	663:690	By applying a two-step aqueous treatment, involving an acid (1.25% v/v aq.
34713756	9	44	theme	extraction	1377:1386	arg1	process					1388:1394	an efficient extraction process	1364:1394	an efficient extraction process	1364:1394	The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process.
34713756	7	45	theme	lignin-rich	1005:1015	arg1	fraction					1017:1024	a lignin-rich fraction	1003:1024	a lignin-rich fraction (70wt%)	1003:1032	Cellulose could be isolated at more than 68%, while a high purity lignin could be recovered from a lignin-rich fraction (70wt%).
34713756	7	45	theme	lignin-rich	1005:1015	arg1	%					1031:1031	70wt%	1027:1031	70wt%	1027:1031	Cellulose could be isolated at more than 68%, while a high purity lignin could be recovered from a lignin-rich fraction (70wt%).
34713756	6	46	theme	tens	821:824	arg1	time					807:810	fixed reaction time	792:810	fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses	792:884	NaOH) at a temperature of 120°C and fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses could be recovered.
34713756	6	46	theme	tens	821:824	arg1	NaOH					756:759	NaOH)	756:760	NaOH) at a temperature of 120°C	756:786	NaOH) at a temperature of 120°C and fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses could be recovered.
34713756	9	47	theme	chemical	1295:1302	arg1	prerequisite					1347:1358	a prerequisite	1345:1358	a prerequisite for an efficient extraction process	1345:1394	The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process.
34713756	9	47	theme	chemical	1295:1302	arg1	analysis					1304:1311	the preliminary chemical analysis	1279:1311	the preliminary chemical analysis of the composition	1279:1330	The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process.
34713756	3	48	dep	%	611:611	arg1	to					613:614	to	613:614	to	613:614	In particular, the protein content can vary from 13wt% to 23wt%, which is accompanied by a change in the hemicelluloses content from 9% to 23% (in the samples of our study).
34713756	9	49	theme	recommended	1255:1265	arg1	pooling					1207:1213	The pooling	1203:1213	The pooling of various materials	1203:1234	The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process.
34713756	9	49	theme	recommended	1255:1265	arg1	option					1267:1272	a recommended option	1253:1272	a recommended option	1253:1272	The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process.
34713756	6	50	theme	few	817:819	arg1	tens					821:824	a few tens	815:824	a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses	815:884	NaOH) at a temperature of 120°C and fixed reaction time of a few tens of minutes (15-90 minutes), more than 80% of hemicelluloses could be recovered.
34713756	3	51	theme	hemicelluloses	582:595	arg1	content					597:603	the hemicelluloses content	578:603	the hemicelluloses content from 9% to 23%	578:618	In particular, the protein content can vary from 13wt% to 23wt%, which is accompanied by a change in the hemicelluloses content from 9% to 23% (in the samples of our study).
34713756	9	52	theme	efficient	1367:1375	arg1	process					1388:1394	an efficient extraction process	1364:1394	an efficient extraction process	1364:1394	The pooling of various materials is therefore not a recommended option, and the preliminary chemical analysis of the composition is therefore a prerequisite for an efficient extraction process.
34713756	4	53	dep	acid	706:709	arg1	v/v					718:720	1.25% v/v aq	712:723	1.25% v/v aq	712:723	By applying a two-step aqueous treatment, involving an acid (1.25% v/v aq.
34713756	2	54	theme	chemical	328:335	arg1	characterisation					337:352	An exhaustive chemical characterisation	314:352	An exhaustive chemical characterisation	314:352	An exhaustive chemical characterisation revealed a variability of composition in distinct batches of BSGs, depending on their origin and the brewing process used.
34713756	2	55	theme	brewing	455:461	arg1	process					463:469	the brewing process	451:469	the brewing process used	451:474	An exhaustive chemical characterisation revealed a variability of composition in distinct batches of BSGs, depending on their origin and the brewing process used.
34713756	4	56	theme	aqueous	674:680	arg1	treatment					682:690	a two-step aqueous treatment	663:690	a two-step aqueous treatment	663:690	By applying a two-step aqueous treatment, involving an acid (1.25% v/v aq.
34713756	2	57	theme	exhaustive	317:326	arg1	characterisation					337:352	An exhaustive chemical characterisation	314:352	An exhaustive chemical characterisation	314:352	An exhaustive chemical characterisation revealed a variability of composition in distinct batches of BSGs, depending on their origin and the brewing process used.
32298570	6	0	theme	in	1053:1054	arg1	experiments					1061:1071	In vitro and in vivo experiments	1040:1071	In vitro and in vivo experiments	1040:1071	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	4	1	theme	interlaced	702:711	arg1	structure					728:736	complex interlaced tubular porous structure	694:736	complex interlaced tubular porous structure	694:736	TMC/AgNPs sponges had complex interlaced tubular porous structure with high porosity (99.42%), indicating high absorption.
32298570	5	2	theme	TMC/AgNPs	903:911	arg1	sponge					913:918	the TMC/AgNPs sponge	899:918	14 days-but the TMC/AgNPs sponge	887:918	TMC had high immobilization efficiency for AgNPs-the release rate of AgNPs was 14.35% after 14 days-but the TMC/AgNPs sponge still had excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
32298570	2	3	from	agents	343:348	arg1	process					368:374	the hemostatic process	353:374	the hemostatic process	353:374	Silver nanoparticles (AgNPs) are suitable as antibacterial agents in the hemostatic process, but the application is hampered because of easy accumulation of toxicity.
32298570	2	4	theme	hemostatic	357:366	arg1	process					368:374	the hemostatic process	353:374	the hemostatic process	353:374	Silver nanoparticles (AgNPs) are suitable as antibacterial agents in the hemostatic process, but the application is hampered because of easy accumulation of toxicity.
32298570	8	5	theme	good	1493:1496	arg1	safety					1498:1503	good safety	1493:1503	good safety	1493:1503	More importantly, the sponges had good safety due to the immobilization of TMC for AgNPs.
32298570	1	6	theme	major	267:271	arg1	challenge					273:281	a major challenge	265:281	a major challenge	265:281	Wound bleeding and infection are two of the major threats to patients' lives, but developing safe materials with high hemostasis efficiency and antibacterial activity remains a major challenge.
32298570	4	7	contain	had	690:692	arg1	sponges					682:688	TMC/AgNPs sponges	672:688	TMC/AgNPs sponges	672:688	TMC/AgNPs sponges had complex interlaced tubular porous structure with high porosity (99.42%), indicating high absorption.
32298570	4	7	contain	had	690:692	arg2	structure					728:736	complex interlaced tubular porous structure	694:736	complex interlaced tubular porous structure	694:736	TMC/AgNPs sponges had complex interlaced tubular porous structure with high porosity (99.42%), indicating high absorption.
32298570	6	8	theme	PVF	1176:1178	arg1	sponge					1180:1185	the PVF sponge	1172:1185	the PVF sponge	1172:1185	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	5	9	theme	AgNPs-the	838:846	arg1	rate					856:859	AgNPs-the release rate	838:859	AgNPs-the release rate of AgNPs	838:868	TMC had high immobilization efficiency for AgNPs-the release rate of AgNPs was 14.35% after 14 days-but the TMC/AgNPs sponge still had excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
32298570	1	10	theme	high	203:206	arg1	efficiency					219:228	high hemostasis efficiency	203:228	high hemostasis efficiency	203:228	Wound bleeding and infection are two of the major threats to patients' lives, but developing safe materials with high hemostasis efficiency and antibacterial activity remains a major challenge.
32298570	4	11	theme	TMC/AgNPs	672:680	arg1	sponges					682:688	TMC/AgNPs sponges	672:688	TMC/AgNPs sponges	672:688	TMC/AgNPs sponges had complex interlaced tubular porous structure with high porosity (99.42%), indicating high absorption.
32298570	6	12	theme	hemostatic	1130:1139	arg1	performance					1141:1151	fast and efficient hemostatic performance	1111:1151	fast and efficient hemostatic performance	1111:1151	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	6	13	dep	In	1040:1041	arg1	vitro					1043:1047	vitro	1043:1047	vitro	1043:1047	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	6	14	theme	absorption	1256:1265	arg1	capacity					1267:1274	high blood absorption capacity	1245:1274	high blood absorption capacity	1245:1274	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	2	15	theme	Silver	284:289	arg1	AgNPs					306:310	AgNPs	306:310	AgNPs	306:310	Silver nanoparticles (AgNPs) are suitable as antibacterial agents in the hemostatic process, but the application is hampered because of easy accumulation of toxicity.
32298570	2	15	theme	Silver	284:289	arg1	nanoparticles					291:303	Silver nanoparticles	284:303	Silver nanoparticles (AgNPs)	284:311	Silver nanoparticles (AgNPs) are suitable as antibacterial agents in the hemostatic process, but the application is hampered because of easy accumulation of toxicity.
32298570	6	16	theme	TMC/AgNPs	1090:1098	arg1	sponge					1100:1105	the TMC/AgNPs sponge	1086:1105	the TMC/AgNPs sponge	1086:1105	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	1	17	theme	developing	172:181	arg1	materials					188:196	safe materials	183:196	developing safe materials with high hemostasis efficiency and antibacterial activity	172:255	Wound bleeding and infection are two of the major threats to patients' lives, but developing safe materials with high hemostasis efficiency and antibacterial activity remains a major challenge.
32298570	7	18	theme	sponge	1444:1449	arg1	cannot					1451:1456	the PVF sponge cannot	1436:1456	the PVF sponge cannot	1436:1456	Furthermore, the TMC/AgNPs sponge can promote wound healing by preventing wound infection, while the PVF sponge cannot.
32298570	6	19	theme	blood	1250:1254	arg1	capacity					1267:1274	high blood absorption capacity	1245:1274	high blood absorption capacity	1245:1274	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	8	20	theme	TMC	1534:1536	arg1	immobilization					1516:1529	the immobilization	1512:1529	the immobilization of TMC for AgNPs	1512:1546	More importantly, the sponges had good safety due to the immobilization of TMC for AgNPs.
32298570	6	21	theme	sulfydryl	1311:1319	arg1	amino					1304:1308	amino	1304:1308	amino	1304:1308	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	1	22	theme	safe	183:186	arg1	materials					188:196	safe materials	183:196	developing safe materials with high hemostasis efficiency and antibacterial activity	172:255	Wound bleeding and infection are two of the major threats to patients' lives, but developing safe materials with high hemostasis efficiency and antibacterial activity remains a major challenge.
32298570	5	23	theme	high	803:806	arg1	efficiency					823:832	high immobilization efficiency	803:832	high immobilization efficiency	803:832	TMC had high immobilization efficiency for AgNPs-the release rate of AgNPs was 14.35% after 14 days-but the TMC/AgNPs sponge still had excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
32298570	2	24	theme	easy	420:423	arg1	accumulation					425:436	easy accumulation	420:436	easy accumulation of toxicity	420:448	Silver nanoparticles (AgNPs) are suitable as antibacterial agents in the hemostatic process, but the application is hampered because of easy accumulation of toxicity.
32298570	6	25	theme	high	1245:1248	arg1	capacity					1267:1274	high blood absorption capacity	1245:1274	high blood absorption capacity	1245:1274	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	4	26	theme	high	743:746	arg1	porosity					748:755	high porosity	743:755	high porosity (99.42%)	743:764	TMC/AgNPs sponges had complex interlaced tubular porous structure with high porosity (99.42%), indicating high absorption.
32298570	4	26	theme	high	743:746	arg1	%					763:763	99.42%	758:763	99.42%	758:763	TMC/AgNPs sponges had complex interlaced tubular porous structure with high porosity (99.42%), indicating high absorption.
32298570	7	27	theme	TMC/AgNPs	1356:1364	arg1	sponge					1366:1371	the TMC/AgNPs sponge	1352:1371	the TMC/AgNPs sponge	1352:1371	Furthermore, the TMC/AgNPs sponge can promote wound healing by preventing wound infection, while the PVF sponge cannot.
32298570	7	28	theme	PVF	1440:1442	arg1	cannot					1451:1456	the PVF sponge cannot	1436:1456	the PVF sponge cannot	1436:1456	Furthermore, the TMC/AgNPs sponge can promote wound healing by preventing wound infection, while the PVF sponge cannot.
32298570	0	29	theme	Thiol-Modified	29:42	arg1	Sponges					81:87	Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges	29:87	Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges	29:87	Antibacterial and Hemostatic Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges.
32298570	7	30	theme	wound	1413:1417	arg1	infection					1419:1427	wound infection	1413:1427	wound infection	1413:1427	Furthermore, the TMC/AgNPs sponge can promote wound healing by preventing wound infection, while the PVF sponge cannot.
32298570	5	31	theme	antibacterial	940:952	arg1	activity					954:961	excellent antibacterial activity	930:961	excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa	930:1037	TMC had high immobilization efficiency for AgNPs-the release rate of AgNPs was 14.35% after 14 days-but the TMC/AgNPs sponge still had excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
32298570	3	32	theme	composite	590:598	arg1	TMC/AgNPs					609:617	TMC/AgNPs	609:617	TMC/AgNPs	609:617	Herein, thiol-modified chitosan (TMC) was prepared by modifying with mercaptosuccinic acid and then was used to immobilize AgNPs to obtain composite sponges (TMC/AgNPs) for stemming the bleeding and preventing infection.
32298570	3	32	theme	composite	590:598	arg1	sponges					600:606	composite sponges	590:606	composite sponges (TMC/AgNPs)	590:618	Herein, thiol-modified chitosan (TMC) was prepared by modifying with mercaptosuccinic acid and then was used to immobilize AgNPs to obtain composite sponges (TMC/AgNPs) for stemming the bleeding and preventing infection.
32298570	5	33	theme	excellent	930:938	arg1	activity					954:961	excellent antibacterial activity	930:961	excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa	930:1037	TMC had high immobilization efficiency for AgNPs-the release rate of AgNPs was 14.35% after 14 days-but the TMC/AgNPs sponge still had excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
32298570	4	34	theme	complex	694:700	arg1	structure					728:736	complex interlaced tubular porous structure	694:736	complex interlaced tubular porous structure	694:736	TMC/AgNPs sponges had complex interlaced tubular porous structure with high porosity (99.42%), indicating high absorption.
32298570	3	35	used	used	555:558	arg2	TMC					484:486	TMC	484:486	TMC	484:486	Herein, thiol-modified chitosan (TMC) was prepared by modifying with mercaptosuccinic acid and then was used to immobilize AgNPs to obtain composite sponges (TMC/AgNPs) for stemming the bleeding and preventing infection.
32298570	3	35	used	used	555:558	arg2	chitosan					474:481	thiol-modified chitosan	459:481	thiol-modified chitosan (TMC)	459:487	Herein, thiol-modified chitosan (TMC) was prepared by modifying with mercaptosuccinic acid and then was used to immobilize AgNPs to obtain composite sponges (TMC/AgNPs) for stemming the bleeding and preventing infection.
32298570	0	36	theme	AgNPs	65:69	arg1	Sponges					81:87	Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges	29:87	Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges	29:87	Antibacterial and Hemostatic Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges.
32298570	4	37	theme	tubular	713:719	arg1	structure					728:736	complex interlaced tubular porous structure	694:736	complex interlaced tubular porous structure	694:736	TMC/AgNPs sponges had complex interlaced tubular porous structure with high porosity (99.42%), indicating high absorption.
32298570	6	38	theme	blood	1326:1330	arg1	cells					1332:1336	amino, sulfydryl, and blood cells	1304:1336	amino, sulfydryl, and blood cells	1304:1336	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	5	39	theme	release	848:854	arg1	rate					856:859	AgNPs-the release rate	838:859	AgNPs-the release rate of AgNPs	838:868	TMC had high immobilization efficiency for AgNPs-the release rate of AgNPs was 14.35% after 14 days-but the TMC/AgNPs sponge still had excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
32298570	0	40	dep	Sponges	81:87	arg1	Hemostatic					18:27	Hemostatic	18:27	Hemostatic	18:27	Antibacterial and Hemostatic Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges.
32298570	0	40	dep	Sponges	81:87	arg1	Antibacterial					0:12	Antibacterial	0:12	Antibacterial	0:12	Antibacterial and Hemostatic Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges.
32298570	5	41	contain	had	926:928	arg1	days-but					890:897	14 days-but	887:897	14 days-but the TMC/AgNPs sponge	887:918	TMC had high immobilization efficiency for AgNPs-the release rate of AgNPs was 14.35% after 14 days-but the TMC/AgNPs sponge still had excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
32298570	5	41	contain	had	926:928	arg2	activity					954:961	excellent antibacterial activity	930:961	excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa	930:1037	TMC had high immobilization efficiency for AgNPs-the release rate of AgNPs was 14.35% after 14 days-but the TMC/AgNPs sponge still had excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
32298570	1	42	theme	hemostasis	208:217	arg1	efficiency					219:228	high hemostasis efficiency	203:228	high hemostasis efficiency	203:228	Wound bleeding and infection are two of the major threats to patients' lives, but developing safe materials with high hemostasis efficiency and antibacterial activity remains a major challenge.
32298570	0	43	theme	Chitosan-Immobilized	44:63	arg1	Sponges					81:87	Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges	29:87	Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges	29:87	Antibacterial and Hemostatic Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges.
32298570	6	44	theme	efficient	1120:1128	arg1	performance					1141:1151	fast and efficient hemostatic performance	1111:1151	fast and efficient hemostatic performance	1111:1151	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	2	45	theme	toxicity	441:448	arg1	accumulation					425:436	easy accumulation	420:436	easy accumulation of toxicity	420:448	Silver nanoparticles (AgNPs) are suitable as antibacterial agents in the hemostatic process, but the application is hampered because of easy accumulation of toxicity.
32298570	8	46	contain	had	1489:1491	arg1	sponges					1481:1487	the sponges	1477:1487	the sponges	1477:1487	More importantly, the sponges had good safety due to the immobilization of TMC for AgNPs.
32298570	8	46	contain	had	1489:1491	arg2	safety					1498:1503	good safety	1493:1503	good safety	1493:1503	More importantly, the sponges had good safety due to the immobilization of TMC for AgNPs.
32298570	3	47	theme	thiol-modified	459:472	arg1	TMC					484:486	TMC	484:486	TMC	484:486	Herein, thiol-modified chitosan (TMC) was prepared by modifying with mercaptosuccinic acid and then was used to immobilize AgNPs to obtain composite sponges (TMC/AgNPs) for stemming the bleeding and preventing infection.
32298570	3	47	theme	thiol-modified	459:472	arg1	chitosan					474:481	thiol-modified chitosan	459:481	thiol-modified chitosan (TMC)	459:487	Herein, thiol-modified chitosan (TMC) was prepared by modifying with mercaptosuccinic acid and then was used to immobilize AgNPs to obtain composite sponges (TMC/AgNPs) for stemming the bleeding and preventing infection.
32298570	6	48	with	comparison	1156:1165	arg1	sponge					1180:1185	the PVF sponge	1172:1185	the PVF sponge	1172:1185	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	5	49	contain	had	799:801	arg2	efficiency					823:832	high immobilization efficiency	803:832	high immobilization efficiency	803:832	TMC had high immobilization efficiency for AgNPs-the release rate of AgNPs was 14.35% after 14 days-but the TMC/AgNPs sponge still had excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
32298570	5	49	contain	had	799:801	arg1	TMC					795:797	TMC	795:797	TMC	795:797	TMC had high immobilization efficiency for AgNPs-the release rate of AgNPs was 14.35% after 14 days-but the TMC/AgNPs sponge still had excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
32298570	6	50	theme	capacity	1267:1274	arg1	mechanism					1205:1213	its possible mechanism	1192:1213	its possible mechanism	1192:1213	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	6	50	theme	capacity	1267:1274	arg1	interaction					1284:1294	the interaction	1280:1294	the interaction between amino, sulfydryl, and blood cells	1280:1336	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	6	50	theme	capacity	1267:1274	arg1	effect					1235:1240	the synergistic effect	1219:1240	the synergistic effect of high blood absorption capacity	1219:1274	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	5	51	dep	days-but	890:897	arg1	sponge					913:918	the TMC/AgNPs sponge	899:918	14 days-but the TMC/AgNPs sponge	887:918	TMC had high immobilization efficiency for AgNPs-the release rate of AgNPs was 14.35% after 14 days-but the TMC/AgNPs sponge still had excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
32298570	4	52	theme	porous	721:726	arg1	structure					728:736	complex interlaced tubular porous structure	694:736	complex interlaced tubular porous structure	694:736	TMC/AgNPs sponges had complex interlaced tubular porous structure with high porosity (99.42%), indicating high absorption.
32298570	0	53	theme	Composite	71:79	arg1	Sponges					81:87	Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges	29:87	Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges	29:87	Antibacterial and Hemostatic Thiol-Modified Chitosan-Immobilized AgNPs Composite Sponges.
32298570	1	54	with	materials	188:196	arg1	activity					248:255	antibacterial activity	234:255	antibacterial activity	234:255	Wound bleeding and infection are two of the major threats to patients' lives, but developing safe materials with high hemostasis efficiency and antibacterial activity remains a major challenge.
32298570	1	54	with	materials	188:196	arg1	efficiency					219:228	high hemostasis efficiency	203:228	high hemostasis efficiency	203:228	Wound bleeding and infection are two of the major threats to patients' lives, but developing safe materials with high hemostasis efficiency and antibacterial activity remains a major challenge.
32298570	5	55	theme	immobilization	808:821	arg1	efficiency					823:832	high immobilization efficiency	803:832	high immobilization efficiency	803:832	TMC had high immobilization efficiency for AgNPs-the release rate of AgNPs was 14.35% after 14 days-but the TMC/AgNPs sponge still had excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
32298570	1	56	theme	major	134:138	arg1	threats					140:146	the major threats	130:146	the major threats to patients' lives	130:165	Wound bleeding and infection are two of the major threats to patients' lives, but developing safe materials with high hemostasis efficiency and antibacterial activity remains a major challenge.
32298570	6	57	dep	in	1053:1054	arg1	vivo					1056:1059	vivo	1056:1059	vivo	1056:1059	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	1	58	theme	threats	140:146	arg1	threats					140:146	the major threats	130:146	the major threats to patients' lives	130:165	Wound bleeding and infection are two of the major threats to patients' lives, but developing safe materials with high hemostasis efficiency and antibacterial activity remains a major challenge.
32298570	1	58	theme	threats	140:146	arg1	two					123:125	two	123:125	two	123:125	Wound bleeding and infection are two of the major threats to patients' lives, but developing safe materials with high hemostasis efficiency and antibacterial activity remains a major challenge.
32298570	6	59	theme	In	1040:1041	arg1	experiments					1061:1071	In vitro and in vivo experiments	1040:1071	In vitro and in vivo experiments	1040:1071	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	6	60	theme	amino	1304:1308	arg1	cells					1332:1336	amino, sulfydryl, and blood cells	1304:1336	amino, sulfydryl, and blood cells	1304:1336	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	6	61	contain	had	1107:1109	arg2	performance					1141:1151	fast and efficient hemostatic performance	1111:1151	fast and efficient hemostatic performance	1111:1151	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	6	61	contain	had	1107:1109	arg1	sponge					1100:1105	the TMC/AgNPs sponge	1086:1105	the TMC/AgNPs sponge	1086:1105	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	4	62	theme	high	778:781	arg1	absorption					783:792	high absorption	778:792	high absorption	778:792	TMC/AgNPs sponges had complex interlaced tubular porous structure with high porosity (99.42%), indicating high absorption.
32298570	2	63	theme	antibacterial	329:341	arg1	agents					343:348	antibacterial agents	329:348	antibacterial agents in the hemostatic process	329:374	Silver nanoparticles (AgNPs) are suitable as antibacterial agents in the hemostatic process, but the application is hampered because of easy accumulation of toxicity.
32298570	1	64	theme	antibacterial	234:246	arg1	activity					248:255	antibacterial activity	234:255	antibacterial activity	234:255	Wound bleeding and infection are two of the major threats to patients' lives, but developing safe materials with high hemostasis efficiency and antibacterial activity remains a major challenge.
32298570	6	65	theme	possible	1196:1203	arg1	mechanism					1205:1213	its possible mechanism	1192:1213	its possible mechanism	1192:1213	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	6	65	theme	possible	1196:1203	arg1	effect					1235:1240	the synergistic effect	1219:1240	the synergistic effect of high blood absorption capacity	1219:1274	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	6	66	theme	synergistic	1223:1233	arg1	mechanism					1205:1213	its possible mechanism	1192:1213	its possible mechanism	1192:1213	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	6	66	theme	synergistic	1223:1233	arg1	effect					1235:1240	the synergistic effect	1219:1240	the synergistic effect of high blood absorption capacity	1219:1274	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	6	67	theme	fast	1111:1114	arg1	performance					1141:1151	fast and efficient hemostatic performance	1111:1151	fast and efficient hemostatic performance	1111:1151	In vitro and in vivo experiments confirm that the TMC/AgNPs sponge had fast and efficient hemostatic performance in comparison with the PVF sponge, and its possible mechanism was the synergistic effect of high blood absorption capacity and the interaction between amino, sulfydryl, and blood cells.
32298570	5	68	theme	AgNPs	864:868	arg1	rate					856:859	AgNPs-the release rate	838:859	AgNPs-the release rate of AgNPs	838:868	TMC had high immobilization efficiency for AgNPs-the release rate of AgNPs was 14.35% after 14 days-but the TMC/AgNPs sponge still had excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
32298570	3	69	theme	mercaptosuccinic	520:535	arg1	acid					537:540	mercaptosuccinic acid	520:540	mercaptosuccinic acid	520:540	Herein, thiol-modified chitosan (TMC) was prepared by modifying with mercaptosuccinic acid and then was used to immobilize AgNPs to obtain composite sponges (TMC/AgNPs) for stemming the bleeding and preventing infection.
32298570	7	70	theme	wound	1385:1389	arg1	healing					1391:1397	wound healing	1385:1397	wound healing	1385:1397	Furthermore, the TMC/AgNPs sponge can promote wound healing by preventing wound infection, while the PVF sponge cannot.
32600700	6	0	theme	50 μM	892:896	arg1	EGCG					898:901	50 μM EGCG	892:901	50 μM EGCG	892:901	In this study, EGCG was combined with tyramine-conjugated HA and gelatin to create a composite hydrogel at an optimized concentration of 50 μM EGCG and 5% w/v HA.
32600700	9	1	theme	hybrid	1159:1164	arg1	hydrogel					1166:1173	EGCG-HA/Gelatin hybrid hydrogel	1143:1173	EGCG-HA/Gelatin hybrid hydrogel	1143:1173	Histological analysis in vivo showed that EGCG-HA/Gelatin hybrid hydrogel minimized cartilage loss in surgically induced OA model.
32600700	10	2	theme	inflammation-modulating	1261:1283	arg1	hydrogel					1294:1301	inflammation-modulating HA-based hydrogel	1261:1301	inflammation-modulating HA-based hydrogel	1261:1301	This study demonstrates that inflammation-modulating HA-based hydrogel may provide a therapeutic option for OA treatment.
32600700	5	3	used	used	716:719	arg2	component					672:680	a major component	664:680	a major component of the cartilage ECM	664:701	Hyaluronic acid (HA), as a major component of the cartilage ECM, is commonly used for cartilage tissue engineering.
32600700	5	3	used	used	716:719	arg2	HA					656:657	HA	656:657	HA	656:657	Hyaluronic acid (HA), as a major component of the cartilage ECM, is commonly used for cartilage tissue engineering.
32600700	5	3	used	used	716:719	arg2	acid					650:653	Hyaluronic acid	639:653	Hyaluronic acid (HA)	639:658	Hyaluronic acid (HA), as a major component of the cartilage ECM, is commonly used for cartilage tissue engineering.
32600700	7	4	theme	composite	922:930	arg1	hydrogel					932:939	The composite hydrogel	918:939	The composite hydrogel	918:939	The composite hydrogel provided protection to chondrocytes against the pro-inflammatory factor, IL-1β.
32600700	2	5	theme	immune	276:281	arg1	reaction					283:290	subsequent immune reaction	265:290	subsequent immune reaction	265:290	Once OA is induced in the joint, subsequent immune reaction leads to chronic inflammation that results in the progression of OA and deconstruction of the cartilage.
32600700	6	6	theme	optimized	865:873	arg1	concentration					875:887	an optimized concentration	862:887	an optimized concentration of 50 μM EGCG and 5% w/v HA	862:915	In this study, EGCG was combined with tyramine-conjugated HA and gelatin to create a composite hydrogel at an optimized concentration of 50 μM EGCG and 5% w/v HA.
32600700	9	7	theme	cartilage	1185:1193	arg1	loss					1195:1198	cartilage loss	1185:1198	cartilage loss in surgically induced OA model	1185:1229	Histological analysis in vivo showed that EGCG-HA/Gelatin hybrid hydrogel minimized cartilage loss in surgically induced OA model.
32600700	2	8	theme	subsequent	265:274	arg1	reaction					283:290	subsequent immune reaction	265:290	subsequent immune reaction	265:290	Once OA is induced in the joint, subsequent immune reaction leads to chronic inflammation that results in the progression of OA and deconstruction of the cartilage.
32600700	5	9	theme	Hyaluronic	639:648	arg1	acid					650:653	Hyaluronic acid	639:653	Hyaluronic acid (HA)	639:658	Hyaluronic acid (HA), as a major component of the cartilage ECM, is commonly used for cartilage tissue engineering.
32600700	5	9	theme	Hyaluronic	639:648	arg1	component					672:680	a major component	664:680	a major component of the cartilage ECM	664:701	Hyaluronic acid (HA), as a major component of the cartilage ECM, is commonly used for cartilage tissue engineering.
32600700	5	9	theme	Hyaluronic	639:648	arg1	HA					656:657	HA	656:657	HA	656:657	Hyaluronic acid (HA), as a major component of the cartilage ECM, is commonly used for cartilage tissue engineering.
32600700	3	10	theme	cartilage	524:532	arg1	regeneration					534:545	cartilage regeneration	524:545	cartilage regeneration	524:545	In this study, an injectable hydrogel with epigallocatechin-3-gallate (EGCG) is introduced to control inflammation and enhance cartilage regeneration.
32600700	3	11	theme	injectable	415:424	arg1	hydrogel					426:433	an injectable hydrogel	412:433	an injectable hydrogel with epigallocatechin-3-gallate (EGCG)	412:472	In this study, an injectable hydrogel with epigallocatechin-3-gallate (EGCG) is introduced to control inflammation and enhance cartilage regeneration.
32600700	0	12	theme	anti-inflammatory	11:27	arg1	hydrogel					45:52	Injectable anti-inflammatory hyaluronic acid hydrogel	0:52	Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair.	0:89	Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair.
32600700	6	13	theme	HA	914:915	arg1	concentration					875:887	an optimized concentration	862:887	an optimized concentration of 50 μM EGCG and 5% w/v HA	862:915	In this study, EGCG was combined with tyramine-conjugated HA and gelatin to create a composite hydrogel at an optimized concentration of 50 μM EGCG and 5% w/v HA.
32600700	8	14	theme	composite	1039:1047	arg1	hydrogel					1049:1056	the composite hydrogel	1035:1056	the composite hydrogel	1035:1056	Additionally, the composite hydrogel led to chondrogenic regeneration in vitro.
32600700	2	15	theme	chronic	301:307	arg1	inflammation					309:320	chronic inflammation	301:320	chronic inflammation that results in the progression of OA and deconstruction of the cartilage	301:394	Once OA is induced in the joint, subsequent immune reaction leads to chronic inflammation that results in the progression of OA and deconstruction of the cartilage.
32600700	2	16	theme	deconstruction	364:377	arg1	progression					342:352	the progression	338:352	the progression of OA and deconstruction of the cartilage	338:394	Once OA is induced in the joint, subsequent immune reaction leads to chronic inflammation that results in the progression of OA and deconstruction of the cartilage.
32600700	0	17	theme	Injectable	0:9	arg1	hydrogel					45:52	Injectable anti-inflammatory hyaluronic acid hydrogel	0:52	Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair.	0:89	Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair.
32600700	6	18	theme	tyramine-conjugated	793:811	arg1	HA					813:814	tyramine-conjugated HA	793:814	tyramine-conjugated HA	793:814	In this study, EGCG was combined with tyramine-conjugated HA and gelatin to create a composite hydrogel at an optimized concentration of 50 μM EGCG and 5% w/v HA.
32600700	9	19	theme	induced	1214:1220	arg1	model					1225:1229	surgically induced OA model	1203:1229	surgically induced OA model	1203:1229	Histological analysis in vivo showed that EGCG-HA/Gelatin hybrid hydrogel minimized cartilage loss in surgically induced OA model.
32600700	10	20	theme	OA	1340:1341	arg1	treatment					1343:1351	OA treatment	1340:1351	OA treatment	1340:1351	This study demonstrates that inflammation-modulating HA-based hydrogel may provide a therapeutic option for OA treatment.
32600700	1	21	theme	joint	187:191	arg1	cartilage					193:201	joint cartilage	187:201	joint cartilage	187:201	Osteoarthritis (OA) is one of the most common cartilage disorder that results from breakdown of joint cartilage and underlying bone tissues.
32600700	0	22	theme	acid	40:43	arg1	hydrogel					45:52	Injectable anti-inflammatory hyaluronic acid hydrogel	0:52	Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair.	0:89	Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair.
32600700	3	23	with	hydrogel	426:433	arg1	EGCG					468:471	EGCG	468:471	EGCG	468:471	In this study, an injectable hydrogel with epigallocatechin-3-gallate (EGCG) is introduced to control inflammation and enhance cartilage regeneration.
32600700	3	23	with	hydrogel	426:433	arg1	epigallocatechin-3-gallate					440:465	epigallocatechin-3-gallate	440:465	epigallocatechin-3-gallate (EGCG)	440:472	In this study, an injectable hydrogel with epigallocatechin-3-gallate (EGCG) is introduced to control inflammation and enhance cartilage regeneration.
32600700	9	24	theme	OA	1222:1223	arg1	model					1225:1229	surgically induced OA model	1203:1229	surgically induced OA model	1203:1229	Histological analysis in vivo showed that EGCG-HA/Gelatin hybrid hydrogel minimized cartilage loss in surgically induced OA model.
32600700	1	25	theme	cartilage	193:201	arg1	breakdown					174:182	breakdown	174:182	breakdown of joint cartilage and underlying bone tissues	174:229	Osteoarthritis (OA) is one of the most common cartilage disorder that results from breakdown of joint cartilage and underlying bone tissues.
32600700	0	26	theme	hyaluronic	29:38	arg1	hydrogel					45:52	Injectable anti-inflammatory hyaluronic acid hydrogel	0:52	Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair.	0:89	Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair.
32600700	5	27	theme	cartilage	689:697	arg1	ECM					699:701	the cartilage ECM	685:701	the cartilage ECM	685:701	Hyaluronic acid (HA), as a major component of the cartilage ECM, is commonly used for cartilage tissue engineering.
32600700	6	28	theme	composite	840:848	arg1	hydrogel					850:857	a composite hydrogel	838:857	a composite hydrogel	838:857	In this study, EGCG was combined with tyramine-conjugated HA and gelatin to create a composite hydrogel at an optimized concentration of 50 μM EGCG and 5% w/v HA.
32600700	4	29	contain	has	553:555	arg2	properties					567:576	intrinsic properties	557:576	intrinsic properties that can modulate inflammation and scavenge radical species	557:636	EGCG has intrinsic properties that can modulate inflammation and scavenge radical species.
32600700	4	29	contain	has	553:555	arg1	EGCG					548:551	EGCG	548:551	EGCG	548:551	EGCG has intrinsic properties that can modulate inflammation and scavenge radical species.
32600700	1	30	theme	cartilage	137:145	arg1	disorder					147:154	the most common cartilage disorder	121:154	the most common cartilage disorder	121:154	Osteoarthritis (OA) is one of the most common cartilage disorder that results from breakdown of joint cartilage and underlying bone tissues.
32600700	4	31	theme	intrinsic	557:565	arg1	properties					567:576	intrinsic properties	557:576	intrinsic properties that can modulate inflammation and scavenge radical species	557:636	EGCG has intrinsic properties that can modulate inflammation and scavenge radical species.
32600700	5	32	theme	ECM	699:701	arg1	component					672:680	a major component	664:680	a major component of the cartilage ECM	664:701	Hyaluronic acid (HA), as a major component of the cartilage ECM, is commonly used for cartilage tissue engineering.
32600700	5	32	theme	ECM	699:701	arg1	acid					650:653	Hyaluronic acid	639:653	Hyaluronic acid (HA)	639:658	Hyaluronic acid (HA), as a major component of the cartilage ECM, is commonly used for cartilage tissue engineering.
32600700	10	33	theme	therapeutic	1317:1327	arg1	option					1329:1334	a therapeutic option	1315:1334	a therapeutic option for OA treatment	1315:1351	This study demonstrates that inflammation-modulating HA-based hydrogel may provide a therapeutic option for OA treatment.
32600700	1	34	theme	underlying	207:216	arg1	tissues					223:229	underlying bone tissues	207:229	underlying bone tissues	207:229	Osteoarthritis (OA) is one of the most common cartilage disorder that results from breakdown of joint cartilage and underlying bone tissues.
32600700	6	35	theme	w/v	910:912	arg1	HA					914:915	5% w/v HA	907:915	5% w/v HA	907:915	In this study, EGCG was combined with tyramine-conjugated HA and gelatin to create a composite hydrogel at an optimized concentration of 50 μM EGCG and 5% w/v HA.
32600700	9	36	theme	Histological	1101:1112	arg1	analysis					1114:1121	Histological analysis	1101:1121	Histological analysis in vivo	1101:1129	Histological analysis in vivo showed that EGCG-HA/Gelatin hybrid hydrogel minimized cartilage loss in surgically induced OA model.
32600700	2	37	theme	cartilage	386:394	arg1	deconstruction					364:377	deconstruction	364:377	deconstruction	364:377	Once OA is induced in the joint, subsequent immune reaction leads to chronic inflammation that results in the progression of OA and deconstruction of the cartilage.
32600700	2	37	theme	cartilage	386:394	arg1	OA					357:358	OA	357:358	OA	357:358	Once OA is induced in the joint, subsequent immune reaction leads to chronic inflammation that results in the progression of OA and deconstruction of the cartilage.
32600700	0	38	theme	cartilage	73:81	arg1	repair					83:88	osteoarthritic cartilage repair	58:88	osteoarthritic cartilage repair	58:88	Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair.
32600700	6	39	theme	%	908:908	arg1	HA					914:915	5% w/v HA	907:915	5% w/v HA	907:915	In this study, EGCG was combined with tyramine-conjugated HA and gelatin to create a composite hydrogel at an optimized concentration of 50 μM EGCG and 5% w/v HA.
32600700	7	40	theme	pro-inflammatory	989:1004	arg1	IL-1β					1014:1018	IL-1β	1014:1018	IL-1β	1014:1018	The composite hydrogel provided protection to chondrocytes against the pro-inflammatory factor, IL-1β.
32600700	7	40	theme	pro-inflammatory	989:1004	arg1	factor					1006:1011	the pro-inflammatory factor	985:1011	the pro-inflammatory factor	985:1011	The composite hydrogel provided protection to chondrocytes against the pro-inflammatory factor, IL-1β.
32600700	0	41	theme	osteoarthritic	58:71	arg1	repair					83:88	osteoarthritic cartilage repair	58:88	osteoarthritic cartilage repair	58:88	Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair.
32600700	6	42	theme	5	907:907	arg1	%					908:908	%	908:908	%	908:908	In this study, EGCG was combined with tyramine-conjugated HA and gelatin to create a composite hydrogel at an optimized concentration of 50 μM EGCG and 5% w/v HA.
32600700	5	43	theme	major	666:670	arg1	component					672:680	a major component	664:680	a major component of the cartilage ECM	664:701	Hyaluronic acid (HA), as a major component of the cartilage ECM, is commonly used for cartilage tissue engineering.
32600700	5	43	theme	major	666:670	arg1	acid					650:653	Hyaluronic acid	639:653	Hyaluronic acid (HA)	639:658	Hyaluronic acid (HA), as a major component of the cartilage ECM, is commonly used for cartilage tissue engineering.
32600700	8	44	theme	chondrogenic	1065:1076	arg1	regeneration					1078:1089	chondrogenic regeneration	1065:1089	chondrogenic regeneration	1065:1089	Additionally, the composite hydrogel led to chondrogenic regeneration in vitro.
32600700	9	45	from	loss	1195:1198	arg1	model					1225:1229	surgically induced OA model	1203:1229	surgically induced OA model	1203:1229	Histological analysis in vivo showed that EGCG-HA/Gelatin hybrid hydrogel minimized cartilage loss in surgically induced OA model.
32600700	1	46	theme	tissues	223:229	arg1	breakdown					174:182	breakdown	174:182	breakdown of joint cartilage and underlying bone tissues	174:229	Osteoarthritis (OA) is one of the most common cartilage disorder that results from breakdown of joint cartilage and underlying bone tissues.
32600700	1	47	theme	common	130:135	arg1	disorder					147:154	the most common cartilage disorder	121:154	the most common cartilage disorder	121:154	Osteoarthritis (OA) is one of the most common cartilage disorder that results from breakdown of joint cartilage and underlying bone tissues.
32600700	5	48	theme	cartilage	725:733	arg1	engineering					742:752	cartilage tissue engineering	725:752	cartilage tissue engineering	725:752	Hyaluronic acid (HA), as a major component of the cartilage ECM, is commonly used for cartilage tissue engineering.
32600700	1	49	theme	bone	218:221	arg1	tissues					223:229	underlying bone tissues	207:229	underlying bone tissues	207:229	Osteoarthritis (OA) is one of the most common cartilage disorder that results from breakdown of joint cartilage and underlying bone tissues.
32600700	2	50	theme	OA	357:358	arg1	progression					342:352	the progression	338:352	the progression of OA and deconstruction of the cartilage	338:394	Once OA is induced in the joint, subsequent immune reaction leads to chronic inflammation that results in the progression of OA and deconstruction of the cartilage.
32600700	5	51	theme	tissue	735:740	arg1	engineering					742:752	cartilage tissue engineering	725:752	cartilage tissue engineering	725:752	Hyaluronic acid (HA), as a major component of the cartilage ECM, is commonly used for cartilage tissue engineering.
32600700	6	52	theme	EGCG	898:901	arg1	concentration					875:887	an optimized concentration	862:887	an optimized concentration of 50 μM EGCG and 5% w/v HA	862:915	In this study, EGCG was combined with tyramine-conjugated HA and gelatin to create a composite hydrogel at an optimized concentration of 50 μM EGCG and 5% w/v HA.
32600700	9	53	theme	EGCG-HA/Gelatin	1143:1157	arg1	hydrogel					1166:1173	EGCG-HA/Gelatin hybrid hydrogel	1143:1173	EGCG-HA/Gelatin hybrid hydrogel	1143:1173	Histological analysis in vivo showed that EGCG-HA/Gelatin hybrid hydrogel minimized cartilage loss in surgically induced OA model.
32600700	1	54	theme	disorder	147:154	arg1	disorder					147:154	the most common cartilage disorder	121:154	the most common cartilage disorder	121:154	Osteoarthritis (OA) is one of the most common cartilage disorder that results from breakdown of joint cartilage and underlying bone tissues.
32600700	1	54	theme	disorder	147:154	arg1	one					114:116	one	114:116	one	114:116	Osteoarthritis (OA) is one of the most common cartilage disorder that results from breakdown of joint cartilage and underlying bone tissues.
32600700	10	55	theme	HA-based	1285:1292	arg1	hydrogel					1294:1301	inflammation-modulating HA-based hydrogel	1261:1301	inflammation-modulating HA-based hydrogel	1261:1301	This study demonstrates that inflammation-modulating HA-based hydrogel may provide a therapeutic option for OA treatment.
32600700	4	56	theme	radical	622:628	arg1	species					630:636	radical species	622:636	radical species	622:636	EGCG has intrinsic properties that can modulate inflammation and scavenge radical species.
33063290	9	0	theme	cell	1916:1919	arg1	progression					1927:1937	cell cycle progression	1916:1937	cell cycle progression inducing the G2/M phase arrest	1916:1968	Moreover, in ALL cells, rhLf-h-glycan altered cell cycle progression inducing the G2/M phase arrest, and caused apoptotic DNA fragmentation.
33063290	2	1	theme	pastoris	387:394	arg1	SuperMan5					396:404	the yeast Pichia pastoris SuperMan5	370:404	the yeast Pichia pastoris SuperMan5	370:404	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	7	2	theme	fluorescent	1456:1466	arg1	staining					1468:1475	fluorescent staining	1456:1475	fluorescent staining	1456:1475	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	10	3	theme	further	2121:2127	arg1	evaluation					2137:2146	further in vivo evaluation	2121:2146	further in vivo evaluation	2121:2146	Overall, our findings revealed that rhLf-h-glycan has potential as an anticancer agent and therefore deserves further in vivo evaluation.
33063290	2	4	theme	humanized	317:325	arg1	rhLf-h-glycan					342:354	rhLf-h-glycan	342:354	rhLf-h-glycan	342:354	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	2	4	theme	humanized	317:325	arg1	glycosylation					327:339	humanized glycosylation	317:339	humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5	317:404	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	6	5	theme	incubation	1392:1401	arg1	incubation					1392:1401	incubation	1392:1401	incubation	1392:1401	Also, rhLf-h-glycan showed significant antiproliferative activity (P < 0.0001) at 24, 48, and 72 h of incubation on CCRF-CEM cells.
33063290	6	5	theme	incubation	1392:1401	arg1	24					1372:1373	24	1372:1373	24	1372:1373	Also, rhLf-h-glycan showed significant antiproliferative activity (P < 0.0001) at 24, 48, and 72 h of incubation on CCRF-CEM cells.
33063290	3	6	theme	cell	754:757	arg1	lines					759:763	four human cell lines	743:763	four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa	743:876	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	8	7	theme	microfilament	1745:1757	arg1	structures					1759:1768	the microfilament structures	1741:1768	the microfilament structures	1741:1768	Furthermore, rhLf-h-glycan-treated HeLa cells revealed shrinkage of the microfilament structures, generating a speckled/punctuated pattern and also caused PARP-1 cleavage, a hallmark of apoptosis.
33063290	1	8	theme	extensive	203:211	arg1	attention					213:221	extensive attention	203:221	extensive attention due to its ample biological properties	203:260	Lactoferrin has gained extensive attention due to its ample biological properties.
33063290	9	9	theme	phase	1957:1961	arg1	arrest					1963:1968	the G2/M phase arrest	1948:1968	the G2/M phase arrest	1948:1968	Moreover, in ALL cells, rhLf-h-glycan altered cell cycle progression inducing the G2/M phase arrest, and caused apoptotic DNA fragmentation.
33063290	1	10	theme	due	223:225	arg1	attention					213:221	extensive attention	203:221	extensive attention due to its ample biological properties	203:260	Lactoferrin has gained extensive attention due to its ample biological properties.
33063290	4	11	theme	rhLf-h-glycan	948:960	arg1	values					938:943	The defined CC50 values	921:943	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells	921:1002	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells were 144.45 ± 4.44, 548.47 ± 64.41, 350 ± 14.82, and 3359.07 ± 164 µg/mL, respectively.
33063290	4	11	theme	rhLf-h-glycan	948:960	arg1	144.45 ± 4.44					1009:1021	144.45 ± 4.44	1009:1021	144.45 ± 4.44	1009:1021	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells were 144.45 ± 4.44, 548.47 ± 64.41, 350 ± 14.82, and 3359.07 ± 164 µg/mL, respectively.
33063290	3	12	theme	lymphoblastic	772:784	arg1	ALL					796:798	ALL	796:798	ALL	796:798	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	12	theme	lymphoblastic	772:784	arg1	leukemia					786:793	acute lymphoblastic leukemia	766:793	acute lymphoblastic leukemia (ALL) CCRF-CEM	766:808	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	4	13	theme	CCRF-CEM	965:972	arg1	HeLa					983:986	CCRF-CEM, SUP-T1, HeLa, and Hs27 cells	965:1002	HeLa	983:986	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells were 144.45 ± 4.44, 548.47 ± 64.41, 350 ± 14.82, and 3359.07 ± 164 µg/mL, respectively.
33063290	10	14	theme	in	2129:2130	arg1	evaluation					2137:2146	further in vivo evaluation	2121:2146	further in vivo evaluation	2121:2146	Overall, our findings revealed that rhLf-h-glycan has potential as an anticancer agent and therefore deserves further in vivo evaluation.
33063290	6	15	theme	significant	1317:1327	arg1	P < 0.0001					1357:1366	P < 0.0001	1357:1366	P < 0.0001	1357:1366	Also, rhLf-h-glycan showed significant antiproliferative activity (P < 0.0001) at 24, 48, and 72 h of incubation on CCRF-CEM cells.
33063290	6	15	theme	significant	1317:1327	arg1	activity					1347:1354	significant antiproliferative activity	1317:1354	significant antiproliferative activity (P < 0.0001)	1317:1367	Also, rhLf-h-glycan showed significant antiproliferative activity (P < 0.0001) at 24, 48, and 72 h of incubation on CCRF-CEM cells.
33063290	3	16	theme	nuclear	645:651	arg1	assay					662:666	The live-cell differential nuclear staining assay	618:666	The live-cell differential nuclear staining assay	618:666	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	1	17	theme	biological	240:249	arg1	properties					251:260	its ample biological properties	230:260	its ample biological properties	230:260	Lactoferrin has gained extensive attention due to its ample biological properties.
33063290	4	18	theme	defined	925:931	arg1	values					938:943	The defined CC50 values	921:943	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells	921:1002	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells were 144.45 ± 4.44, 548.47 ± 64.41, 350 ± 14.82, and 3359.07 ± 164 µg/mL, respectively.
33063290	4	18	theme	defined	925:931	arg1	144.45 ± 4.44					1009:1021	144.45 ± 4.44	1009:1021	144.45 ± 4.44	1009:1021	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells were 144.45 ± 4.44, 548.47 ± 64.41, 350 ± 14.82, and 3359.07 ± 164 µg/mL, respectively.
33063290	9	19	theme	DNA	1992:1994	arg1	fragmentation					1996:2008	apoptotic DNA fragmentation	1982:2008	apoptotic DNA fragmentation	1982:2008	Moreover, in ALL cells, rhLf-h-glycan altered cell cycle progression inducing the G2/M phase arrest, and caused apoptotic DNA fragmentation.
33063290	4	20	from	values	938:943	arg1	HeLa					983:986	CCRF-CEM, SUP-T1, HeLa, and Hs27 cells	965:1002	HeLa	983:986	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells were 144.45 ± 4.44, 548.47 ± 64.41, 350 ± 14.82, and 3359.07 ± 164 µg/mL, respectively.
33063290	4	20	from	values	938:943	arg1	cells					998:1002	CCRF-CEM, SUP-T1, HeLa, and Hs27 cells	965:1002	cells	998:1002	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells were 144.45 ± 4.44, 548.47 ± 64.41, 350 ± 14.82, and 3359.07 ± 164 µg/mL, respectively.
33063290	3	21	theme	live-cell	622:630	arg1	assay					662:666	The live-cell differential nuclear staining assay	618:666	The live-cell differential nuclear staining assay	618:666	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	22	theme	control	886:892	arg1	cells					914:918	control, non-cancerous Hs27 cells	886:918	cells	914:918	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	22	theme	control	886:892	arg1	cytotoxicity					707:718	the rhLf-h-glycan cytotoxicity	689:718	the rhLf-h-glycan cytotoxicity	689:718	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	2	23	theme	cancer	604:609	arg1	cells					611:615	cancer cells	604:615	cancer cells	604:615	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	2	24	link	Asn-linked	528:537	arg1	glycans					539:545	(Man)5(GlcNAc)2 Asn-linked glycans	512:545	(Man)5(GlcNAc)2 Asn-linked glycans	512:545	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	5	25	theme	Hs27	1278:1281	arg1	cells					1283:1287	Hs27 cells	1278:1287	Hs27 cells	1278:1287	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	2	26	theme	recombinant	278:288	arg1	lactoferrin					296:306	recombinant human lactoferrin	278:306	recombinant human lactoferrin	278:306	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	8	27	theme	PARP-1	1828:1833	arg1	cleavage					1835:1842	PARP-1 cleavage	1828:1842	PARP-1 cleavage	1828:1842	Furthermore, rhLf-h-glycan-treated HeLa cells revealed shrinkage of the microfilament structures, generating a speckled/punctuated pattern and also caused PARP-1 cleavage, a hallmark of apoptosis.
33063290	8	27	theme	PARP-1	1828:1833	arg1	hallmark					1847:1854	a hallmark	1845:1854	a hallmark of apoptosis	1845:1867	Furthermore, rhLf-h-glycan-treated HeLa cells revealed shrinkage of the microfilament structures, generating a speckled/punctuated pattern and also caused PARP-1 cleavage, a hallmark of apoptosis.
33063290	3	28	theme	lymphoblastic	818:830	arg1	lymphoma					832:839	T-cell lymphoblastic lymphoma	811:839	T-cell lymphoblastic lymphoma SUP-T1	811:846	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	0	29	theme	selective	85:93	arg1	cytotoxicity					95:106	antileukemia selective cytotoxicity	72:106	antileukemia selective cytotoxicity	72:106	Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.
33063290	7	30	theme	nuclear	1591:1597	arg1	fragmentation					1599:1611	nuclear fragmentation	1591:1611	nuclear fragmentation	1591:1611	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	3	31	used	used	672:675	arg2	assay					662:666	The live-cell differential nuclear staining assay	618:666	The live-cell differential nuclear staining assay	618:666	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	10	32	theme	anticancer	2081:2090	arg1	agent					2092:2096	an anticancer agent	2078:2096	an anticancer agent	2078:2096	Overall, our findings revealed that rhLf-h-glycan has potential as an anticancer agent and therefore deserves further in vivo evaluation.
33063290	10	32	theme	anticancer	2081:2090	arg1	potential					2065:2073	potential	2065:2073	potential	2065:2073	Overall, our findings revealed that rhLf-h-glycan has potential as an anticancer agent and therefore deserves further in vivo evaluation.
33063290	7	33	from	condensation	1624:1635	arg1	cells					1666:1670	ALL cells	1662:1670	ALL cells	1662:1670	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	3	34	theme	non-cancerous	895:907	arg1	cells					914:918	control, non-cancerous Hs27 cells	886:918	cells	914:918	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	34	theme	non-cancerous	895:907	arg1	cytotoxicity					707:718	the rhLf-h-glycan cytotoxicity	689:718	the rhLf-h-glycan cytotoxicity	689:718	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	35	theme	cervical	849:856	arg1	CCRF-CEM					801:808	acute lymphoblastic leukemia (ALL) CCRF-CEM	766:808	acute lymphoblastic leukemia (ALL) CCRF-CEM	766:808	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	35	theme	cervical	849:856	arg1	HeLa					873:876	cervical adenocarcinoma HeLa	849:876	cervical adenocarcinoma HeLa	849:876	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	5	36	theme	favorable	1122:1130	arg1	cells					1198:1202	killing cancer cells	1183:1202	preferentially killing cancer cells	1168:1202	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	5	36	theme	favorable	1122:1130	arg1	SCI					1162:1164	SCI	1162:1164	SCI	1162:1164	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	5	36	theme	favorable	1122:1130	arg1	index					1155:1159	a favorable selective cytotoxicity index	1120:1159	a favorable selective cytotoxicity index (SCI)	1120:1165	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	8	37	theme	apoptosis	1859:1867	arg1	cleavage					1835:1842	PARP-1 cleavage	1828:1842	PARP-1 cleavage	1828:1842	Furthermore, rhLf-h-glycan-treated HeLa cells revealed shrinkage of the microfilament structures, generating a speckled/punctuated pattern and also caused PARP-1 cleavage, a hallmark of apoptosis.
33063290	8	37	theme	apoptosis	1859:1867	arg1	hallmark					1847:1854	a hallmark	1845:1854	a hallmark of apoptosis	1845:1867	Furthermore, rhLf-h-glycan-treated HeLa cells revealed shrinkage of the microfilament structures, generating a speckled/punctuated pattern and also caused PARP-1 cleavage, a hallmark of apoptosis.
33063290	10	38	contain	has	2061:2063	arg1	rhLf-h-glycan					2047:2059	rhLf-h-glycan	2047:2059	rhLf-h-glycan	2047:2059	Overall, our findings revealed that rhLf-h-glycan has potential as an anticancer agent and therefore deserves further in vivo evaluation.
33063290	10	38	contain	has	2061:2063	arg2	agent					2092:2096	an anticancer agent	2078:2096	an anticancer agent	2078:2096	Overall, our findings revealed that rhLf-h-glycan has potential as an anticancer agent and therefore deserves further in vivo evaluation.
33063290	10	38	contain	has	2061:2063	arg2	potential					2065:2073	potential	2065:2073	potential	2065:2073	Overall, our findings revealed that rhLf-h-glycan has potential as an anticancer agent and therefore deserves further in vivo evaluation.
33063290	0	39	theme	cell	135:138	arg1	arrest					146:151	cell cycle arrest	135:151	cell cycle arrest	135:151	Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.
33063290	5	40	theme	cytotoxicity	1142:1153	arg1	cells					1198:1202	killing cancer cells	1183:1202	preferentially killing cancer cells	1168:1202	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	5	40	theme	cytotoxicity	1142:1153	arg1	SCI					1162:1164	SCI	1162:1164	SCI	1162:1164	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	5	40	theme	cytotoxicity	1142:1153	arg1	index					1155:1159	a favorable selective cytotoxicity index	1120:1159	a favorable selective cytotoxicity index (SCI)	1120:1165	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	7	41	from	bodies	1652:1657	arg1	cells					1666:1670	ALL cells	1662:1670	ALL cells	1662:1670	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	2	42	theme	Man	513:515	arg1	glycans					539:545	(Man)5(GlcNAc)2 Asn-linked glycans	512:545	(Man)5(GlcNAc)2 Asn-linked glycans	512:545	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	0	43	theme	Recombinant	0:10	arg1	lactoferrin					18:28	Recombinant human lactoferrin	0:28	Recombinant human lactoferrin carrying humanized glycosylation	0:61	Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.
33063290	2	44	theme	humanized	478:486	arg1	glycoproteins					488:500	functional humanized glycoproteins	467:500	functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans	467:545	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	6	45	theme	CCRF-CEM	1406:1413	arg1	cells					1415:1419	CCRF-CEM cells	1406:1419	CCRF-CEM cells	1406:1419	Also, rhLf-h-glycan showed significant antiproliferative activity (P < 0.0001) at 24, 48, and 72 h of incubation on CCRF-CEM cells.
33063290	7	46	theme	morphological	1550:1562	arg1	bodies					1652:1657	apoptotic bodies	1642:1657	apoptotic bodies	1642:1657	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	7	46	theme	morphological	1550:1562	arg1	blebbing					1581:1588	blebbing	1581:1588	blebbing	1581:1588	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	7	46	theme	morphological	1550:1562	arg1	fragmentation					1599:1611	nuclear fragmentation	1591:1611	nuclear fragmentation	1591:1611	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	7	46	theme	morphological	1550:1562	arg1	condensation					1624:1635	chromatin condensation	1614:1635	chromatin condensation	1614:1635	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	7	46	theme	morphological	1550:1562	arg1	changes					1564:1570	apoptosis-associated morphological changes	1529:1570	apoptosis-associated morphological changes	1529:1570	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	3	47	theme	rhLf-h-glycan	693:705	arg1	cells					914:918	control, non-cancerous Hs27 cells	886:918	cells	914:918	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	47	theme	rhLf-h-glycan	693:705	arg1	cytotoxicity					707:718	the rhLf-h-glycan cytotoxicity	689:718	the rhLf-h-glycan cytotoxicity	689:718	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	0	48	theme	humanized	39:47	arg1	glycosylation					49:61	humanized glycosylation	39:61	humanized glycosylation	39:61	Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.
33063290	7	49	from	blebbing	1581:1588	arg1	cells					1666:1670	ALL cells	1662:1670	ALL cells	1662:1670	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	2	50	theme	Pichia	380:385	arg1	SuperMan5					396:404	the yeast Pichia pastoris SuperMan5	370:404	the yeast Pichia pastoris SuperMan5	370:404	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	5	51	theme	cancer	1191:1196	arg1	cells					1198:1202	killing cancer cells	1183:1202	preferentially killing cancer cells	1168:1202	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	5	51	theme	cancer	1191:1196	arg1	index					1155:1159	a favorable selective cytotoxicity index	1120:1159	a favorable selective cytotoxicity index (SCI)	1120:1165	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	7	52	theme	confocal	1481:1488	arg1	microscopy					1490:1499	confocal microscopy	1481:1499	confocal microscopy	1481:1499	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	5	53	theme	killing	1183:1189	arg1	cells					1198:1202	killing cancer cells	1183:1202	preferentially killing cancer cells	1168:1202	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	5	53	theme	killing	1183:1189	arg1	index					1155:1159	a favorable selective cytotoxicity index	1120:1159	a favorable selective cytotoxicity index (SCI)	1120:1165	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	3	54	theme	human	748:752	arg1	lines					759:763	four human cell lines	743:763	four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa	743:876	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	8	55	theme	rhLf-h-glycan-treated	1686:1706	arg1	cells					1713:1717	rhLf-h-glycan-treated HeLa cells	1686:1717	rhLf-h-glycan-treated HeLa cells	1686:1717	Furthermore, rhLf-h-glycan-treated HeLa cells revealed shrinkage of the microfilament structures, generating a speckled/punctuated pattern and also caused PARP-1 cleavage, a hallmark of apoptosis.
33063290	10	56	dep	in	2129:2130	arg1	vivo					2132:2135	vivo	2132:2135	vivo	2132:2135	Overall, our findings revealed that rhLf-h-glycan has potential as an anticancer agent and therefore deserves further in vivo evaluation.
33063290	9	57	theme	cycle	1921:1925	arg1	progression					1927:1937	cell cycle progression	1916:1937	cell cycle progression inducing the G2/M phase arrest	1916:1968	Moreover, in ALL cells, rhLf-h-glycan altered cell cycle progression inducing the G2/M phase arrest, and caused apoptotic DNA fragmentation.
33063290	3	58	theme	acute	766:770	arg1	ALL					796:798	ALL	796:798	ALL	796:798	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	58	theme	acute	766:770	arg1	leukemia					786:793	acute lymphoblastic leukemia	766:793	acute lymphoblastic leukemia (ALL) CCRF-CEM	766:808	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	9	59	theme	G2/M	1952:1955	arg1	arrest					1963:1968	the G2/M phase arrest	1948:1968	the G2/M phase arrest	1948:1968	Moreover, in ALL cells, rhLf-h-glycan altered cell cycle progression inducing the G2/M phase arrest, and caused apoptotic DNA fragmentation.
33063290	0	60	contain	carrying	30:37	arg1	lactoferrin					18:28	Recombinant human lactoferrin	0:28	Recombinant human lactoferrin carrying humanized glycosylation	0:61	Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.
33063290	0	60	contain	carrying	30:37	arg2	glycosylation					49:61	humanized glycosylation	39:61	humanized glycosylation	39:61	Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.
33063290	4	61	dep	HeLa	983:986	arg1	SUP-T1					975:980	CCRF-CEM, SUP-T1, HeLa, and Hs27 cells	965:1002	SUP-T1	975:980	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells were 144.45 ± 4.44, 548.47 ± 64.41, 350 ± 14.82, and 3359.07 ± 164 µg/mL, respectively.
33063290	8	62	theme	structures	1759:1768	arg1	shrinkage					1728:1736	shrinkage	1728:1736	shrinkage of the microfilament structures	1728:1768	Furthermore, rhLf-h-glycan-treated HeLa cells revealed shrinkage of the microfilament structures, generating a speckled/punctuated pattern and also caused PARP-1 cleavage, a hallmark of apoptosis.
33063290	7	63	theme	apoptotic	1642:1650	arg1	bodies					1652:1657	apoptotic bodies	1642:1657	apoptotic bodies	1642:1657	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	2	64	theme	potential	577:585	arg1	toxicity					587:594	its potential toxicity	573:594	its potential toxicity against cancer cells	573:615	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	3	65	theme	leukemia	786:793	arg1	SUP-T1					841:846	T-cell lymphoblastic lymphoma SUP-T1	811:846	T-cell lymphoblastic lymphoma SUP-T1	811:846	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	65	theme	leukemia	786:793	arg1	CCRF-CEM					801:808	acute lymphoblastic leukemia (ALL) CCRF-CEM	766:808	acute lymphoblastic leukemia (ALL) CCRF-CEM	766:808	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	65	theme	leukemia	786:793	arg1	HeLa					873:876	cervical adenocarcinoma HeLa	849:876	cervical adenocarcinoma HeLa	849:876	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	6	66	theme	antiproliferative	1329:1345	arg1	P < 0.0001					1357:1366	P < 0.0001	1357:1366	P < 0.0001	1357:1366	Also, rhLf-h-glycan showed significant antiproliferative activity (P < 0.0001) at 24, 48, and 72 h of incubation on CCRF-CEM cells.
33063290	6	66	theme	antiproliferative	1329:1345	arg1	activity					1347:1354	significant antiproliferative activity	1317:1354	significant antiproliferative activity (P < 0.0001)	1317:1367	Also, rhLf-h-glycan showed significant antiproliferative activity (P < 0.0001) at 24, 48, and 72 h of incubation on CCRF-CEM cells.
33063290	3	67	theme	differential	632:643	arg1	assay					662:666	The live-cell differential nuclear staining assay	618:666	The live-cell differential nuclear staining assay	618:666	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	1	68	theme	ample	234:238	arg1	properties					251:260	its ample biological properties	230:260	its ample biological properties	230:260	Lactoferrin has gained extensive attention due to its ample biological properties.
33063290	9	69	theme	apoptotic	1982:1990	arg1	fragmentation					1996:2008	apoptotic DNA fragmentation	1982:2008	apoptotic DNA fragmentation	1982:2008	Moreover, in ALL cells, rhLf-h-glycan altered cell cycle progression inducing the G2/M phase arrest, and caused apoptotic DNA fragmentation.
33063290	3	70	theme	T-cell	811:816	arg1	lymphoma					832:839	T-cell lymphoblastic lymphoma	811:839	T-cell lymphoblastic lymphoma SUP-T1	811:846	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	8	71	theme	speckled/punctuated	1784:1802	arg1	pattern					1804:1810	a speckled/punctuated pattern	1782:1810	a speckled/punctuated pattern	1782:1810	Furthermore, rhLf-h-glycan-treated HeLa cells revealed shrinkage of the microfilament structures, generating a speckled/punctuated pattern and also caused PARP-1 cleavage, a hallmark of apoptosis.
33063290	7	72	theme	chromatin	1614:1622	arg1	condensation					1624:1635	chromatin condensation	1614:1635	chromatin condensation	1614:1635	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	2	73	theme	human	290:294	arg1	lactoferrin					296:306	recombinant human lactoferrin	278:306	recombinant human lactoferrin	278:306	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	4	74	theme	CC50	933:936	arg1	values					938:943	The defined CC50 values	921:943	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells	921:1002	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells were 144.45 ± 4.44, 548.47 ± 64.41, 350 ± 14.82, and 3359.07 ± 164 µg/mL, respectively.
33063290	4	74	theme	CC50	933:936	arg1	144.45 ± 4.44					1009:1021	144.45 ± 4.44	1009:1021	144.45 ± 4.44	1009:1021	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells were 144.45 ± 4.44, 548.47 ± 64.41, 350 ± 14.82, and 3359.07 ± 164 µg/mL, respectively.
33063290	3	75	theme	staining	653:660	arg1	assay					662:666	The live-cell differential nuclear staining assay	618:666	The live-cell differential nuclear staining assay	618:666	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	2	76	theme	Asn-linked	528:537	arg1	glycans					539:545	(Man)5(GlcNAc)2 Asn-linked glycans	512:545	(Man)5(GlcNAc)2 Asn-linked glycans	512:545	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	3	77	theme	lymphoma	832:839	arg1	SUP-T1					841:846	T-cell lymphoblastic lymphoma SUP-T1	811:846	T-cell lymphoblastic lymphoma SUP-T1	811:846	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	77	theme	lymphoma	832:839	arg1	CCRF-CEM					801:808	acute lymphoblastic leukemia (ALL) CCRF-CEM	766:808	acute lymphoblastic leukemia (ALL) CCRF-CEM	766:808	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	0	78	theme	microfilament	109:121	arg1	disruption					123:132	microfilament disruption	109:132	microfilament disruption	109:132	Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.
33063290	4	79	theme	Hs27	993:996	arg1	cells					998:1002	CCRF-CEM, SUP-T1, HeLa, and Hs27 cells	965:1002	cells	998:1002	The defined CC50 values of rhLf-h-glycan in CCRF-CEM, SUP-T1, HeLa, and Hs27 cells were 144.45 ± 4.44, 548.47 ± 64.41, 350 ± 14.82, and 3359.07 ± 164 µg/mL, respectively.
33063290	3	80	theme	Hs27	909:912	arg1	cells					914:918	control, non-cancerous Hs27 cells	886:918	cells	914:918	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	80	theme	Hs27	909:912	arg1	cytotoxicity					707:718	the rhLf-h-glycan cytotoxicity	689:718	the rhLf-h-glycan cytotoxicity	689:718	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	81	theme	adenocarcinoma	858:871	arg1	CCRF-CEM					801:808	acute lymphoblastic leukemia (ALL) CCRF-CEM	766:808	acute lymphoblastic leukemia (ALL) CCRF-CEM	766:808	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	81	theme	adenocarcinoma	858:871	arg1	HeLa					873:876	cervical adenocarcinoma HeLa	849:876	cervical adenocarcinoma HeLa	849:876	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	0	82	theme	cycle	140:144	arg1	arrest					146:151	cell cycle arrest	135:151	cell cycle arrest	135:151	Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.
33063290	5	83	theme	selective	1132:1140	arg1	cells					1198:1202	killing cancer cells	1183:1202	preferentially killing cancer cells	1168:1202	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	5	83	theme	selective	1132:1140	arg1	SCI					1162:1164	SCI	1162:1164	SCI	1162:1164	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	5	83	theme	selective	1132:1140	arg1	index					1155:1159	a favorable selective cytotoxicity index	1120:1159	a favorable selective cytotoxicity index (SCI)	1120:1165	The rhLf-h-glycan exhibited a favorable selective cytotoxicity index (SCI), preferentially killing cancer cells: 23.25 for CCRF-CEM, 9.59 for HeLa, and 6.12 for SUP-T1, as compared with Hs27 cells.
33063290	0	84	theme	human	12:16	arg1	lactoferrin					18:28	Recombinant human lactoferrin	0:28	Recombinant human lactoferrin carrying humanized glycosylation	0:61	Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.
33063290	2	85	contain	carrying	308:315	arg1	lactoferrin					296:306	recombinant human lactoferrin	278:306	recombinant human lactoferrin	278:306	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	2	85	contain	carrying	308:315	arg2	glycosylation					327:339	humanized glycosylation	317:339	humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5	317:404	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	2	85	contain	carrying	308:315	arg2	rhLf-h-glycan					342:354	rhLf-h-glycan	342:354	rhLf-h-glycan	342:354	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	0	86	dep	cytotoxicity	95:106	arg1	activities					168:177	activities	168:177	activities	168:177	Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.
33063290	2	87	theme	functional	467:476	arg1	glycoproteins					488:500	functional humanized glycoproteins	467:500	functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans	467:545	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	0	88	theme	antileukemia	72:83	arg1	cytotoxicity					95:106	antileukemia selective cytotoxicity	72:106	antileukemia selective cytotoxicity	72:106	Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.
33063290	3	89	dep	lines	759:763	arg1	SUP-T1					841:846	T-cell lymphoblastic lymphoma SUP-T1	811:846	T-cell lymphoblastic lymphoma SUP-T1	811:846	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	89	dep	lines	759:763	arg1	CCRF-CEM					801:808	acute lymphoblastic leukemia (ALL) CCRF-CEM	766:808	acute lymphoblastic leukemia (ALL) CCRF-CEM	766:808	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	3	89	dep	lines	759:763	arg1	HeLa					873:876	cervical adenocarcinoma HeLa	849:876	cervical adenocarcinoma HeLa	849:876	The live-cell differential nuclear staining assay was used to quantify the rhLf-h-glycan cytotoxicity, which was examined in four human cell lines: acute lymphoblastic leukemia (ALL) CCRF-CEM, T-cell lymphoblastic lymphoma SUP-T1, cervical adenocarcinoma HeLa, and as control, non-cancerous Hs27 cells.
33063290	7	90	theme	apoptosis-associated	1529:1548	arg1	bodies					1652:1657	apoptotic bodies	1642:1657	apoptotic bodies	1642:1657	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	7	90	theme	apoptosis-associated	1529:1548	arg1	blebbing					1581:1588	blebbing	1581:1588	blebbing	1581:1588	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	7	90	theme	apoptosis-associated	1529:1548	arg1	fragmentation					1599:1611	nuclear fragmentation	1591:1611	nuclear fragmentation	1591:1611	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	7	90	theme	apoptosis-associated	1529:1548	arg1	condensation					1624:1635	chromatin condensation	1614:1635	chromatin condensation	1614:1635	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	7	90	theme	apoptosis-associated	1529:1548	arg1	changes					1564:1570	apoptosis-associated morphological changes	1529:1570	apoptosis-associated morphological changes	1529:1570	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	2	91	theme	yeast	374:378	arg1	SuperMan5					396:404	the yeast Pichia pastoris SuperMan5	370:404	the yeast Pichia pastoris SuperMan5	370:404	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	7	92	from	fragmentation	1599:1611	arg1	cells					1666:1670	ALL cells	1662:1670	ALL cells	1662:1670	Additionally, it was observed via fluorescent staining and confocal microscopy that rhLf-h-glycan elicited apoptosis-associated morphological changes, such as blebbing, nuclear fragmentation, chromatin condensation, and apoptotic bodies in ALL cells.
33063290	2	93	gly	glycoproteins	488:500	arg1	glycoproteins					488:500	functional humanized glycoproteins	467:500	functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans	467:545	In this study, recombinant human lactoferrin carrying humanized glycosylation (rhLf-h-glycan) expressed in the yeast Pichia pastoris SuperMan5, which is genetically glycoengineered to efficiently produce functional humanized glycoproteins inclosing (Man)5(GlcNAc)2 Asn-linked glycans, was analyzed, inspecting its potential toxicity against cancer cells.
33063290	8	94	theme	HeLa	1708:1711	arg1	cells					1713:1717	rhLf-h-glycan-treated HeLa cells	1686:1717	rhLf-h-glycan-treated HeLa cells	1686:1717	Furthermore, rhLf-h-glycan-treated HeLa cells revealed shrinkage of the microfilament structures, generating a speckled/punctuated pattern and also caused PARP-1 cleavage, a hallmark of apoptosis.
32292818	2	0	theme	matrix	562:567	arg1	mechanics					569:577	matrix mechanics	562:577	matrix mechanics	562:577	While methods for characterizing hydrogels exist and are widely used, they often do not measure diffusive and convective transport concurrently, determine the relationship between microstructure and transport properties, and decouple matrix mechanics and transport properties.
32292818	9	1	dep	three-dimensional	1827:1843	arg1	3-D					1846:1848	3-D	1846:1848	3-D	1846:1848	The integrated techniques are versatile, robust, and accessible; and as matrix-cell interactions are instrumental for many biological processes, the methods and findings described here should be broadly applicable for characterizing hydrogel materials used for three-dimensional (3-D) tissue-engineered culture models.
32292818	4	2	theme	I	790:790	arg1	matrix					813:818	the base matrix	804:818	the base matrix	804:818	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	2	theme	I	790:790	arg1	collagen					792:799	fibrillar type I collagen	775:799	fibrillar type I collagen	775:799	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	1	3	theme	matrices	196:203	arg1	properties					159:168	the biophysical properties	143:168	the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis	143:325	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
32292818	9	4	theme	tissue-engineered	1851:1867	arg1	models					1877:1882	three-dimensional (3-D) tissue-engineered culture models	1827:1882	three-dimensional (3-D) tissue-engineered culture models	1827:1882	The integrated techniques are versatile, robust, and accessible; and as matrix-cell interactions are instrumental for many biological processes, the methods and findings described here should be broadly applicable for characterizing hydrogel materials used for three-dimensional (3-D) tissue-engineered culture models.
32292818	1	5	theme	reflectance	295:305	arg1	microscopy					307:316	confocal reflectance microscopy	286:316	confocal reflectance microscopy analysis	286:325	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
32292818	9	6	theme	integrated	1570:1579	arg1	versatile					1596:1604	versatile	1596:1604	versatile	1596:1604	The integrated techniques are versatile, robust, and accessible; and as matrix-cell interactions are instrumental for many biological processes, the methods and findings described here should be broadly applicable for characterizing hydrogel materials used for three-dimensional (3-D) tissue-engineered culture models.
32292818	9	6	theme	integrated	1570:1579	arg1	techniques					1581:1590	The integrated techniques	1566:1590	The integrated techniques	1566:1590	The integrated techniques are versatile, robust, and accessible; and as matrix-cell interactions are instrumental for many biological processes, the methods and findings described here should be broadly applicable for characterizing hydrogel materials used for three-dimensional (3-D) tissue-engineered culture models.
32292818	4	7	theme	type	785:788	arg1	matrix					813:818	the base matrix	804:818	the base matrix	804:818	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	7	theme	type	785:788	arg1	collagen					792:799	fibrillar type I collagen	775:799	fibrillar type I collagen	775:799	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	1	8	theme	microscopy	307:316	arg1	analysis					318:325	confocal reflectance microscopy analysis	286:325	confocal reflectance microscopy analysis	286:325	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
32292818	4	9	theme	constituent	1018:1028	arg1	HA					1047:1048	HA	1047:1048	HA	1047:1048	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	9	theme	constituent	1018:1028	arg1	acid					1041:1044	the nonfibrillar matrix constituent hyaluronic acid	994:1044	the nonfibrillar matrix constituent hyaluronic acid (HA)	994:1049	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	10	theme	matrix	866:871	arg1	cross-linking					892:904	(1) cross-linking	888:904	(1) cross-linking with human recombinant tissue transglutaminase II (hrTGII)	888:963	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	10	theme	matrix	866:871	arg1	modifications					873:885	two different matrix modifications	852:885	two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA)	852:1049	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	10	theme	matrix	866:871	arg1	supplementation					973:987	(2) supplementation	969:987	(2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA)	969:1049	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	7	11	from	concentrations	1310:1323	arg1	supplementation					1266:1280	supplementation	1266:1280	supplementation of HA at different collagen concentrations	1266:1323	In contrast, supplementation of HA at different collagen concentrations altered the matrix microstructure and mechanical indentation behavior but not transport parameters.
32292818	6	12	theme	collagen	1243:1250	arg1	concentration					1226:1238	the concentration	1222:1238	the concentration of collagen	1222:1250	Furthermore, changes in the matrix structure due to hrTGII were seen to be dependent on the concentration of collagen.
32292818	4	13	theme	matrix	1011:1016	arg1	HA					1047:1048	HA	1047:1048	HA	1047:1048	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	13	theme	matrix	1011:1016	arg1	acid					1041:1044	the nonfibrillar matrix constituent hyaluronic acid	994:1044	the nonfibrillar matrix constituent hyaluronic acid (HA)	994:1049	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	6	14	theme	matrix	1162:1167	arg1	structure					1169:1177	the matrix structure	1158:1177	the matrix structure due to hrTGII	1158:1191	Furthermore, changes in the matrix structure due to hrTGII were seen to be dependent on the concentration of collagen.
32292818	7	15	theme	collagen	1301:1308	arg1	concentrations					1310:1323	different collagen concentrations	1291:1323	different collagen concentrations	1291:1323	In contrast, supplementation of HA at different collagen concentrations altered the matrix microstructure and mechanical indentation behavior but not transport parameters.
32292818	3	16	theme	independent	637:647	arg1	measurements					666:677	independent and quantitative measurements	637:677	independent and quantitative measurements of the structural, mechanical, and transport properties of hydrogels in a single study	637:764	Our integrated approach enabled independent and quantitative measurements of the structural, mechanical, and transport properties of hydrogels in a single study.
32292818	9	17	theme	biological	1689:1698	arg1	processes					1700:1708	many biological processes	1684:1708	many biological processes	1684:1708	The integrated techniques are versatile, robust, and accessible; and as matrix-cell interactions are instrumental for many biological processes, the methods and findings described here should be broadly applicable for characterizing hydrogel materials used for three-dimensional (3-D) tissue-engineered culture models.
32292818	4	18	theme	recombinant	917:927	arg1	transglutaminase					936:951	human recombinant tissue transglutaminase II	911:954	human recombinant tissue transglutaminase II (hrTGII)	911:963	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	18	theme	recombinant	917:927	arg1	hrTGII					957:962	hrTGII	957:962	hrTGII	957:962	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	19	dep	cross-linking	892:904	arg1	1					889:889	1	889:889	1	889:889	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	3	20	theme	integrated	609:618	arg1	approach					620:627	Our integrated approach	605:627	Our integrated approach	605:627	Our integrated approach enabled independent and quantitative measurements of the structural, mechanical, and transport properties of hydrogels in a single study.
32292818	2	21	theme	transport	583:591	arg1	properties					593:602	transport properties	583:602	transport properties	583:602	While methods for characterizing hydrogels exist and are widely used, they often do not measure diffusive and convective transport concurrently, determine the relationship between microstructure and transport properties, and decouple matrix mechanics and transport properties.
32292818	4	22	theme	human	911:915	arg1	transglutaminase					936:951	human recombinant tissue transglutaminase II	911:954	human recombinant tissue transglutaminase II (hrTGII)	911:963	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	22	theme	human	911:915	arg1	hrTGII					957:962	hrTGII	957:962	hrTGII	957:962	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	23	with	cross-linking	892:904	arg1	acid					1041:1044	the nonfibrillar matrix constituent hyaluronic acid	994:1044	the nonfibrillar matrix constituent hyaluronic acid (HA)	994:1049	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	23	with	cross-linking	892:904	arg1	HA					1047:1048	HA	1047:1048	HA	1047:1048	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	23	with	cross-linking	892:904	arg1	transglutaminase					936:951	human recombinant tissue transglutaminase II	911:954	human recombinant tissue transglutaminase II (hrTGII)	911:963	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	23	with	cross-linking	892:904	arg1	hrTGII					957:962	hrTGII	957:962	hrTGII	957:962	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	2	24	theme	convective	438:447	arg1	transport					449:457	diffusive and convective transport	424:457	transport	449:457	While methods for characterizing hydrogels exist and are widely used, they often do not measure diffusive and convective transport concurrently, determine the relationship between microstructure and transport properties, and decouple matrix mechanics and transport properties.
32292818	0	25	theme	Biophysical	11:21	arg1	Characterization					23:38	Biophysical Characterization	11:38	Biophysical Characterization of Fibrillar Collagen-Based Hydrogels	11:76	Integrated Biophysical Characterization of Fibrillar Collagen-Based Hydrogels.
32292818	2	26	used	used	392:395	arg2	methods					334:340	methods	334:340	methods for characterizing hydrogels	334:369	While methods for characterizing hydrogels exist and are widely used, they often do not measure diffusive and convective transport concurrently, determine the relationship between microstructure and transport properties, and decouple matrix mechanics and transport properties.
32292818	1	27	theme	experimental	103:114	arg1	scheme					133:138	an experimental characterization scheme	100:138	an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis	100:325	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
32292818	4	28	with	supplementation	973:987	arg1	HA					1047:1048	HA	1047:1048	HA	1047:1048	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	28	with	supplementation	973:987	arg1	transglutaminase					936:951	human recombinant tissue transglutaminase II	911:954	human recombinant tissue transglutaminase II (hrTGII)	911:963	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	28	with	supplementation	973:987	arg1	acid					1041:1044	the nonfibrillar matrix constituent hyaluronic acid	994:1044	the nonfibrillar matrix constituent hyaluronic acid (HA)	994:1049	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	28	with	supplementation	973:987	arg1	hrTGII					957:962	hrTGII	957:962	hrTGII	957:962	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	29	dep	modifications	873:885	arg1	cross-linking					892:904	(1) cross-linking	888:904	(1) cross-linking with human recombinant tissue transglutaminase II (hrTGII)	888:963	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	29	dep	modifications	873:885	arg1	modifications					873:885	two different matrix modifications	852:885	two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA)	852:1049	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	29	dep	modifications	873:885	arg1	supplementation					973:987	(2) supplementation	969:987	(2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA)	969:1049	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	30	theme	tissue	929:934	arg1	transglutaminase					936:951	human recombinant tissue transglutaminase II	911:954	human recombinant tissue transglutaminase II (hrTGII)	911:963	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	30	theme	tissue	929:934	arg1	hrTGII					957:962	hrTGII	957:962	hrTGII	957:962	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	31	used	used	770:773	arg2	We					767:768	We	767:768	We	767:768	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	1	32	theme	characterization	116:131	arg1	scheme					133:138	an experimental characterization scheme	100:138	an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis	100:325	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
32292818	0	33	theme	Hydrogels	68:76	arg1	Characterization					23:38	Biophysical Characterization	11:38	Biophysical Characterization of Fibrillar Collagen-Based Hydrogels	11:76	Integrated Biophysical Characterization of Fibrillar Collagen-Based Hydrogels.
32292818	2	34	theme	diffusive	424:432	arg1	transport					449:457	diffusive and convective transport	424:457	transport	449:457	While methods for characterizing hydrogels exist and are widely used, they often do not measure diffusive and convective transport concurrently, determine the relationship between microstructure and transport properties, and decouple matrix mechanics and transport properties.
32292818	9	35	theme	three-dimensional	1827:1843	arg1	models					1877:1882	three-dimensional (3-D) tissue-engineered culture models	1827:1882	three-dimensional (3-D) tissue-engineered culture models	1827:1882	The integrated techniques are versatile, robust, and accessible; and as matrix-cell interactions are instrumental for many biological processes, the methods and findings described here should be broadly applicable for characterizing hydrogel materials used for three-dimensional (3-D) tissue-engineered culture models.
32292818	6	36	from	changes	1147:1153	arg1	structure					1169:1177	the matrix structure	1158:1177	the matrix structure due to hrTGII	1158:1191	Furthermore, changes in the matrix structure due to hrTGII were seen to be dependent on the concentration of collagen.
32292818	8	37	theme	important	1468:1476	arg1	relationship					1478:1489	the important relationship	1464:1489	the important relationship between extracellular matrix (ECM) composition and biophysical properties	1464:1563	These experimental observations reveal the important relationship between extracellular matrix (ECM) composition and biophysical properties.
32292818	4	38	theme	different	856:864	arg1	cross-linking					892:904	(1) cross-linking	888:904	(1) cross-linking with human recombinant tissue transglutaminase II (hrTGII)	888:963	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	38	theme	different	856:864	arg1	modifications					873:885	two different matrix modifications	852:885	two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA)	852:1049	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	38	theme	different	856:864	arg1	supplementation					973:987	(2) supplementation	969:987	(2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA)	969:1049	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	8	39	theme	extracellular	1499:1511	arg1	ECM					1521:1523	ECM	1521:1523	ECM	1521:1523	These experimental observations reveal the important relationship between extracellular matrix (ECM) composition and biophysical properties.
32292818	8	39	theme	extracellular	1499:1511	arg1	matrix					1513:1518	extracellular matrix	1499:1518	extracellular matrix (ECM) composition	1499:1536	These experimental observations reveal the important relationship between extracellular matrix (ECM) composition and biophysical properties.
32292818	3	40	theme	quantitative	653:664	arg1	measurements					666:677	independent and quantitative measurements	637:677	independent and quantitative measurements of the structural, mechanical, and transport properties of hydrogels in a single study	637:764	Our integrated approach enabled independent and quantitative measurements of the structural, mechanical, and transport properties of hydrogels in a single study.
32292818	9	41	theme	matrix-cell	1638:1648	arg1	interactions					1650:1661	matrix-cell interactions	1638:1661	matrix-cell interactions	1638:1661	The integrated techniques are versatile, robust, and accessible; and as matrix-cell interactions are instrumental for many biological processes, the methods and findings described here should be broadly applicable for characterizing hydrogel materials used for three-dimensional (3-D) tissue-engineered culture models.
32292818	4	42	theme	fibrillar	775:783	arg1	matrix					813:818	the base matrix	804:818	the base matrix	804:818	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	42	theme	fibrillar	775:783	arg1	collagen					792:799	fibrillar type I collagen	775:799	fibrillar type I collagen	775:799	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	0	43	theme	Collagen-Based	53:66	arg1	Hydrogels					68:76	Fibrillar Collagen-Based Hydrogels	43:76	Fibrillar Collagen-Based Hydrogels	43:76	Integrated Biophysical Characterization of Fibrillar Collagen-Based Hydrogels.
32292818	9	44	theme	many	1684:1687	arg1	processes					1700:1708	many biological processes	1684:1708	many biological processes	1684:1708	The integrated techniques are versatile, robust, and accessible; and as matrix-cell interactions are instrumental for many biological processes, the methods and findings described here should be broadly applicable for characterizing hydrogel materials used for three-dimensional (3-D) tissue-engineered culture models.
32292818	4	45	theme	nonfibrillar	998:1009	arg1	HA					1047:1048	HA	1047:1048	HA	1047:1048	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	45	theme	nonfibrillar	998:1009	arg1	acid					1041:1044	the nonfibrillar matrix constituent hyaluronic acid	994:1044	the nonfibrillar matrix constituent hyaluronic acid (HA)	994:1049	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	7	46	theme	mechanical	1363:1372	arg1	behavior					1386:1393	mechanical indentation behavior	1363:1393	mechanical indentation behavior	1363:1393	In contrast, supplementation of HA at different collagen concentrations altered the matrix microstructure and mechanical indentation behavior but not transport parameters.
32292818	8	47	theme	matrix	1513:1518	arg1	composition					1526:1536	extracellular matrix (ECM) composition	1499:1536	extracellular matrix (ECM) composition	1499:1536	These experimental observations reveal the important relationship between extracellular matrix (ECM) composition and biophysical properties.
32292818	7	48	theme	transport	1403:1411	arg1	parameters					1413:1422	transport parameters	1403:1422	transport parameters	1403:1422	In contrast, supplementation of HA at different collagen concentrations altered the matrix microstructure and mechanical indentation behavior but not transport parameters.
32292818	1	49	theme	transport	253:261	arg1	testing					226:232	indentation testing	214:232	indentation testing	214:232	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
32292818	1	49	theme	transport	253:261	arg1	analysis					318:325	confocal reflectance microscopy analysis	286:325	confocal reflectance microscopy analysis	286:325	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
32292818	1	49	theme	transport	253:261	arg1	quantification					235:248	quantification	235:248	quantification of transport via microfluidics	235:279	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
32292818	0	50	theme	Fibrillar	43:51	arg1	Hydrogels					68:76	Fibrillar Collagen-Based Hydrogels	43:76	Fibrillar Collagen-Based Hydrogels	43:76	Integrated Biophysical Characterization of Fibrillar Collagen-Based Hydrogels.
32292818	3	51	theme	mechanical	698:707	arg1	measurements					666:677	independent and quantitative measurements	637:677	independent and quantitative measurements of the structural, mechanical, and transport properties of hydrogels in a single study	637:764	Our integrated approach enabled independent and quantitative measurements of the structural, mechanical, and transport properties of hydrogels in a single study.
32292818	4	52	theme	hyaluronic	1030:1039	arg1	HA					1047:1048	HA	1047:1048	HA	1047:1048	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	52	theme	hyaluronic	1030:1039	arg1	acid					1041:1044	the nonfibrillar matrix constituent hyaluronic acid	994:1044	the nonfibrillar matrix constituent hyaluronic acid (HA)	994:1049	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	8	53	theme	experimental	1431:1442	arg1	observations					1444:1455	These experimental observations	1425:1455	These experimental observations	1425:1455	These experimental observations reveal the important relationship between extracellular matrix (ECM) composition and biophysical properties.
32292818	3	54	theme	hydrogels	738:746	arg1	mechanical					698:707	mechanical	698:707	mechanical	698:707	Our integrated approach enabled independent and quantitative measurements of the structural, mechanical, and transport properties of hydrogels in a single study.
32292818	5	55	theme	transport	1093:1101	arg1	parameters					1122:1131	transport but not mechanical parameters	1093:1131	transport but not mechanical parameters	1093:1131	hrTGII modified the matrix structure and transport but not mechanical parameters.
32292818	6	56	theme	due	1179:1181	arg1	structure					1169:1177	the matrix structure	1158:1177	the matrix structure due to hrTGII	1158:1191	Furthermore, changes in the matrix structure due to hrTGII were seen to be dependent on the concentration of collagen.
32292818	2	57	theme	transport	527:535	arg1	properties					537:546	transport properties	527:546	transport properties	527:546	While methods for characterizing hydrogels exist and are widely used, they often do not measure diffusive and convective transport concurrently, determine the relationship between microstructure and transport properties, and decouple matrix mechanics and transport properties.
32292818	9	58	theme	culture	1869:1875	arg1	models					1877:1882	three-dimensional (3-D) tissue-engineered culture models	1827:1882	three-dimensional (3-D) tissue-engineered culture models	1827:1882	The integrated techniques are versatile, robust, and accessible; and as matrix-cell interactions are instrumental for many biological processes, the methods and findings described here should be broadly applicable for characterizing hydrogel materials used for three-dimensional (3-D) tissue-engineered culture models.
32292818	5	59	theme	mechanical	1111:1120	arg1	parameters					1122:1131	transport but not mechanical parameters	1093:1131	transport but not mechanical parameters	1093:1131	hrTGII modified the matrix structure and transport but not mechanical parameters.
32292818	1	60	theme	biophysical	147:157	arg1	properties					159:168	the biophysical properties	143:168	the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis	143:325	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
32292818	4	61	theme	modifications	873:885	arg1	effects					841:847	the effects	837:847	the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA)	837:1049	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	3	62	theme	transport	714:722	arg1	properties					724:733	the structural, mechanical, and transport properties	682:733	properties	724:733	Our integrated approach enabled independent and quantitative measurements of the structural, mechanical, and transport properties of hydrogels in a single study.
32292818	4	63	dep	supplementation	973:987	arg1	2					970:970	2	970:970	2	970:970	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	1	64	theme	properties	159:168	arg1	scheme					133:138	an experimental characterization scheme	100:138	an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis	100:325	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
32292818	3	65	theme	single	753:758	arg1	study					760:764	a single study	751:764	a single study	751:764	Our integrated approach enabled independent and quantitative measurements of the structural, mechanical, and transport properties of hydrogels in a single study.
32292818	3	66	theme	properties	724:733	arg1	measurements					666:677	independent and quantitative measurements	637:677	independent and quantitative measurements of the structural, mechanical, and transport properties of hydrogels in a single study	637:764	Our integrated approach enabled independent and quantitative measurements of the structural, mechanical, and transport properties of hydrogels in a single study.
32292818	7	67	theme	matrix	1337:1342	arg1	microstructure					1344:1357	the matrix microstructure	1333:1357	the matrix microstructure	1333:1357	In contrast, supplementation of HA at different collagen concentrations altered the matrix microstructure and mechanical indentation behavior but not transport parameters.
32292818	3	68	from	measurements	666:677	arg1	study					760:764	a single study	751:764	a single study	751:764	Our integrated approach enabled independent and quantitative measurements of the structural, mechanical, and transport properties of hydrogels in a single study.
32292818	4	69	theme	base	808:811	arg1	matrix					813:818	the base matrix	804:818	the base matrix	804:818	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	4	69	theme	base	808:811	arg1	collagen					792:799	fibrillar type I collagen	775:799	fibrillar type I collagen	775:799	We used fibrillar type I collagen as the base matrix and investigated the effects of two different matrix modifications: (1) cross-linking with human recombinant tissue transglutaminase II (hrTGII) and (2) supplementation with the nonfibrillar matrix constituent hyaluronic acid (HA).
32292818	7	70	theme	HA	1285:1286	arg1	supplementation					1266:1280	supplementation	1266:1280	supplementation of HA at different collagen concentrations	1266:1323	In contrast, supplementation of HA at different collagen concentrations altered the matrix microstructure and mechanical indentation behavior but not transport parameters.
32292818	7	71	theme	indentation	1374:1384	arg1	behavior					1386:1393	mechanical indentation behavior	1363:1393	mechanical indentation behavior	1363:1393	In contrast, supplementation of HA at different collagen concentrations altered the matrix microstructure and mechanical indentation behavior but not transport parameters.
32292818	8	72	theme	biophysical	1542:1552	arg1	properties					1554:1563	biophysical properties	1542:1563	biophysical properties	1542:1563	These experimental observations reveal the important relationship between extracellular matrix (ECM) composition and biophysical properties.
32292818	1	73	theme	reconstituted	173:185	arg1	matrices					196:203	reconstituted hydrogel matrices	173:203	reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis	173:325	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
32292818	1	74	theme	indentation	214:224	arg1	testing					226:232	indentation testing	214:232	indentation testing	214:232	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
32292818	9	75	theme	hydrogel	1799:1806	arg1	materials					1808:1816	hydrogel materials	1799:1816	hydrogel materials used for three-dimensional (3-D) tissue-engineered culture models	1799:1882	The integrated techniques are versatile, robust, and accessible; and as matrix-cell interactions are instrumental for many biological processes, the methods and findings described here should be broadly applicable for characterizing hydrogel materials used for three-dimensional (3-D) tissue-engineered culture models.
32292818	5	76	theme	matrix	1072:1077	arg1	structure					1079:1087	the matrix structure	1068:1087	the matrix structure	1068:1087	hrTGII modified the matrix structure and transport but not mechanical parameters.
32292818	1	77	theme	hydrogel	187:194	arg1	matrices					196:203	reconstituted hydrogel matrices	173:203	reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis	173:325	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
32292818	7	78	theme	different	1291:1299	arg1	concentrations					1310:1323	different collagen concentrations	1291:1323	different collagen concentrations	1291:1323	In contrast, supplementation of HA at different collagen concentrations altered the matrix microstructure and mechanical indentation behavior but not transport parameters.
32292818	1	79	theme	confocal	286:293	arg1	microscopy					307:316	confocal reflectance microscopy	286:316	confocal reflectance microscopy analysis	286:325	This paper describes an experimental characterization scheme of the biophysical properties of reconstituted hydrogel matrices based on indentation testing, quantification of transport via microfluidics, and confocal reflectance microscopy analysis.
33910725	8	0	theme	unloaded	1093:1100	arg1	films					1102:1106	unloaded films	1093:1106	unloaded films	1093:1106	Finally, a scratch test on a keratinocytes monolayer showed that the rate of cell migration in the presence of OPU-loaded samples is about 3-fold higher compared to unloaded films, confirming the repairing activity of OPU.
33910725	0	1	theme	extract	85:91	arg1	delivery					52:59	in situ delivery	44:59	in situ delivery of Opuntia ficus-indica extract	44:91	PEG-crosslinked-chitosan hydrogel films for in situ delivery of Opuntia ficus-indica extract.
33910725	6	2	theme	modulus	768:774	arg1	value					744:748	the value	740:748	the value of the human skin modulus	740:774	Tensile tests evidenced that the crosslinking caused a decrease of Young's modulus, which approaches the value of the human skin modulus.
33910725	4	3	theme	FTIR	532:535	arg1	spectroscopy					537:548	FTIR spectroscopy	532:548	FTIR spectroscopy	532:548	The occurrence of crosslinking reaction was confirmed by FTIR spectroscopy.
33910725	3	4	theme	molecular	323:331	arg1	glycol					362:367	ethylene glycol	353:367	ethylene glycol	353:367	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	3	4	theme	molecular	323:331	arg1	diePEG					371:376	diePEG	371:376	diePEG	371:376	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	3	4	theme	molecular	323:331	arg1	weight					333:338	a low molecular weight diepoxy-poly	317:351	a low molecular weight diepoxy-poly(ethylene glycol) (diePEG)	317:377	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	5	5	theme	DSC	560:562	arg1	analysis					564:571	FTIR and DSC analysis	551:571	analysis	564:571	FTIR and DSC analysis suggested that ionic interactions occur between chitosan and OPU.
33910725	6	6	theme	human	757:761	arg1	modulus					768:774	the human skin modulus	753:774	the human skin modulus	753:774	Tensile tests evidenced that the crosslinking caused a decrease of Young's modulus, which approaches the value of the human skin modulus.
33910725	2	7	theme	injury	267:272	arg1	repair					274:279	skin injury repair	262:279	skin injury repair	262:279	OPU is known for its capability to accelerate skin injury repair.
33910725	7	8	theme	transmission	815:826	arg1	rate					828:831	water vapor transmission rate	803:831	water vapor transmission rate	803:831	Swelling characteristics, water vapor transmission rate, and release kinetics demonstrated that these films are adequate for the proposed application.
33910725	8	9	from	test	947:950	arg1	monolayer					971:979	a keratinocytes monolayer	955:979	a keratinocytes monolayer	955:979	Finally, a scratch test on a keratinocytes monolayer showed that the rate of cell migration in the presence of OPU-loaded samples is about 3-fold higher compared to unloaded films, confirming the repairing activity of OPU.
33910725	8	10	theme	cell	1005:1008	arg1	migration					1010:1018	cell migration	1005:1018	cell migration	1005:1018	Finally, a scratch test on a keratinocytes monolayer showed that the rate of cell migration in the presence of OPU-loaded samples is about 3-fold higher compared to unloaded films, confirming the repairing activity of OPU.
33910725	8	11	theme	scratch	939:945	arg1	test					947:950	a scratch test	937:950	a scratch test on a keratinocytes monolayer	937:979	Finally, a scratch test on a keratinocytes monolayer showed that the rate of cell migration in the presence of OPU-loaded samples is about 3-fold higher compared to unloaded films, confirming the repairing activity of OPU.
33910725	2	12	theme	skin	262:265	arg1	repair					274:279	skin injury repair	262:279	skin injury repair	262:279	OPU is known for its capability to accelerate skin injury repair.
33910725	3	13	theme	hydrogel	384:391	arg1	films					393:397	hydrogel films	384:397	hydrogel films with different Ch/PEG composition and OPU content	384:447	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	3	14	theme	low	319:321	arg1	glycol					362:367	ethylene glycol	353:367	ethylene glycol	353:367	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	3	14	theme	low	319:321	arg1	diePEG					371:376	diePEG	371:376	diePEG	371:376	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	3	14	theme	low	319:321	arg1	weight					333:338	a low molecular weight diepoxy-poly	317:351	a low molecular weight diepoxy-poly(ethylene glycol) (diePEG)	317:377	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	5	15	theme	ionic	588:592	arg1	interactions					594:605	ionic interactions	588:605	ionic interactions	588:605	FTIR and DSC analysis suggested that ionic interactions occur between chitosan and OPU.
33910725	8	16	theme	repairing	1124:1132	arg1	activity					1134:1141	the repairing activity	1120:1141	the repairing activity of OPU	1120:1148	Finally, a scratch test on a keratinocytes monolayer showed that the rate of cell migration in the presence of OPU-loaded samples is about 3-fold higher compared to unloaded films, confirming the repairing activity of OPU.
33910725	7	17	theme	water	803:807	arg1	rate					828:831	water vapor transmission rate	803:831	water vapor transmission rate	803:831	Swelling characteristics, water vapor transmission rate, and release kinetics demonstrated that these films are adequate for the proposed application.
33910725	0	18	theme	hydrogel	25:32	arg1	films					34:38	PEG-crosslinked-chitosan hydrogel films	0:38	PEG-crosslinked-chitosan hydrogel films for in situ delivery of Opuntia ficus-indica extract.	0:92	PEG-crosslinked-chitosan hydrogel films for in situ delivery of Opuntia ficus-indica extract.
33910725	7	19	theme	vapor	809:813	arg1	rate					828:831	water vapor transmission rate	803:831	water vapor transmission rate	803:831	Swelling characteristics, water vapor transmission rate, and release kinetics demonstrated that these films are adequate for the proposed application.
33910725	1	20	theme	ficus-indica	182:193	arg1	extract					163:169	the extract	159:169	the extract of Opuntia ficus-indica (OPU)	159:199	In the present study, chitosan-based wound dressings loaded with the extract of Opuntia ficus-indica (OPU) were prepared.
33910725	0	21	theme	PEG-crosslinked-chitosan	0:23	arg1	films					34:38	PEG-crosslinked-chitosan hydrogel films	0:38	PEG-crosslinked-chitosan hydrogel films for in situ delivery of Opuntia ficus-indica extract.	0:92	PEG-crosslinked-chitosan hydrogel films for in situ delivery of Opuntia ficus-indica extract.
33910725	8	22	from	rate	997:1000	arg1	presence					1027:1034	the presence	1023:1034	the presence of OPU-loaded samples	1023:1056	Finally, a scratch test on a keratinocytes monolayer showed that the rate of cell migration in the presence of OPU-loaded samples is about 3-fold higher compared to unloaded films, confirming the repairing activity of OPU.
33910725	8	23	theme	migration	1010:1018	arg1	higher					1074:1079	higher	1074:1079	higher	1074:1079	Finally, a scratch test on a keratinocytes monolayer showed that the rate of cell migration in the presence of OPU-loaded samples is about 3-fold higher compared to unloaded films, confirming the repairing activity of OPU.
33910725	8	23	theme	migration	1010:1018	arg1	rate					997:1000	the rate	993:1000	the rate of cell migration in the presence of OPU-loaded samples	993:1056	Finally, a scratch test on a keratinocytes monolayer showed that the rate of cell migration in the presence of OPU-loaded samples is about 3-fold higher compared to unloaded films, confirming the repairing activity of OPU.
33910725	3	24	theme	diepoxy-poly	340:351	arg1	glycol					362:367	ethylene glycol	353:367	ethylene glycol	353:367	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	3	24	theme	diepoxy-poly	340:351	arg1	diePEG					371:376	diePEG	371:376	diePEG	371:376	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	3	24	theme	diepoxy-poly	340:351	arg1	weight					333:338	a low molecular weight diepoxy-poly	317:351	a low molecular weight diepoxy-poly(ethylene glycol) (diePEG)	317:377	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	4	25	theme	reaction	506:513	arg1	occurrence					479:488	The occurrence	475:488	The occurrence of crosslinking reaction	475:513	The occurrence of crosslinking reaction was confirmed by FTIR spectroscopy.
33910725	5	26	theme	FTIR	551:554	arg1	analysis					564:571	FTIR and DSC analysis	551:571	analysis	564:571	FTIR and DSC analysis suggested that ionic interactions occur between chitosan and OPU.
33910725	1	27	theme	present	101:107	arg1	study					109:113	the present study	97:113	the present study	97:113	In the present study, chitosan-based wound dressings loaded with the extract of Opuntia ficus-indica (OPU) were prepared.
33910725	3	28	theme	Ch/PEG	414:419	arg1	composition					421:431	different Ch/PEG composition	404:431	different Ch/PEG composition	404:431	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	6	29	theme	Tensile	639:645	arg1	tests					647:651	Tensile tests	639:651	Tensile tests	639:651	Tensile tests evidenced that the crosslinking caused a decrease of Young's modulus, which approaches the value of the human skin modulus.
33910725	8	30	theme	OPU-loaded	1039:1048	arg1	samples					1050:1056	OPU-loaded samples	1039:1056	OPU-loaded samples	1039:1056	Finally, a scratch test on a keratinocytes monolayer showed that the rate of cell migration in the presence of OPU-loaded samples is about 3-fold higher compared to unloaded films, confirming the repairing activity of OPU.
33910725	7	31	theme	Swelling	777:784	arg1	characteristics					786:800	Swelling characteristics	777:800	Swelling characteristics	777:800	Swelling characteristics, water vapor transmission rate, and release kinetics demonstrated that these films are adequate for the proposed application.
33910725	0	32	theme	in	44:45	arg1	delivery					52:59	in situ delivery	44:59	in situ delivery of Opuntia ficus-indica extract	44:91	PEG-crosslinked-chitosan hydrogel films for in situ delivery of Opuntia ficus-indica extract.
33910725	8	33	theme	OPU	1146:1148	arg1	activity					1134:1141	the repairing activity	1120:1141	the repairing activity of OPU	1120:1148	Finally, a scratch test on a keratinocytes monolayer showed that the rate of cell migration in the presence of OPU-loaded samples is about 3-fold higher compared to unloaded films, confirming the repairing activity of OPU.
33910725	3	34	theme	different	404:412	arg1	composition					421:431	different Ch/PEG composition	404:431	different Ch/PEG composition	404:431	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	7	35	theme	proposed	906:913	arg1	application					915:925	the proposed application	902:925	the proposed application	902:925	Swelling characteristics, water vapor transmission rate, and release kinetics demonstrated that these films are adequate for the proposed application.
33910725	4	36	theme	crosslinking	493:504	arg1	reaction					506:513	crosslinking reaction	493:513	crosslinking reaction	493:513	The occurrence of crosslinking reaction was confirmed by FTIR spectroscopy.
33910725	8	37	theme	samples	1050:1056	arg1	presence					1027:1034	the presence	1023:1034	the presence of OPU-loaded samples	1023:1056	Finally, a scratch test on a keratinocytes monolayer showed that the rate of cell migration in the presence of OPU-loaded samples is about 3-fold higher compared to unloaded films, confirming the repairing activity of OPU.
33910725	0	38	dep	in	44:45	arg1	situ					47:50	situ	47:50	situ	47:50	PEG-crosslinked-chitosan hydrogel films for in situ delivery of Opuntia ficus-indica extract.
33910725	1	39	theme	chitosan-based	116:129	arg1	dressings					137:145	chitosan-based wound dressings	116:145	chitosan-based wound dressings loaded with the extract of Opuntia ficus-indica (OPU)	116:199	In the present study, chitosan-based wound dressings loaded with the extract of Opuntia ficus-indica (OPU) were prepared.
33910725	8	40	theme	keratinocytes	957:969	arg1	monolayer					971:979	a keratinocytes monolayer	955:979	a keratinocytes monolayer	955:979	Finally, a scratch test on a keratinocytes monolayer showed that the rate of cell migration in the presence of OPU-loaded samples is about 3-fold higher compared to unloaded films, confirming the repairing activity of OPU.
33910725	6	41	theme	skin	763:766	arg1	modulus					768:774	the human skin modulus	753:774	the human skin modulus	753:774	Tensile tests evidenced that the crosslinking caused a decrease of Young's modulus, which approaches the value of the human skin modulus.
33910725	1	42	theme	wound	131:135	arg1	dressings					137:145	chitosan-based wound dressings	116:145	chitosan-based wound dressings loaded with the extract of Opuntia ficus-indica (OPU)	116:199	In the present study, chitosan-based wound dressings loaded with the extract of Opuntia ficus-indica (OPU) were prepared.
33910725	3	43	with	films	393:397	arg1	content					441:447	OPU content	437:447	OPU content	437:447	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	3	43	with	films	393:397	arg1	composition					421:431	different Ch/PEG composition	404:431	different Ch/PEG composition	404:431	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	6	44	theme	Young	706:710	arg1	modulus					714:720	Young's modulus	706:720	Young's modulus	706:720	Tensile tests evidenced that the crosslinking caused a decrease of Young's modulus, which approaches the value of the human skin modulus.
33910725	3	45	theme	OPU	437:439	arg1	content					441:447	OPU content	437:447	OPU content	437:447	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	0	46	theme	ficus-indica	72:83	arg1	extract					85:91	Opuntia ficus-indica extract	64:91	Opuntia ficus-indica extract	64:91	PEG-crosslinked-chitosan hydrogel films for in situ delivery of Opuntia ficus-indica extract.
33910725	0	47	theme	Opuntia	64:70	arg1	extract					85:91	Opuntia ficus-indica extract	64:91	Opuntia ficus-indica extract	64:91	PEG-crosslinked-chitosan hydrogel films for in situ delivery of Opuntia ficus-indica extract.
33910725	3	48	theme	ethylene	353:360	arg1	glycol					362:367	ethylene glycol	353:367	ethylene glycol	353:367	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	3	48	theme	ethylene	353:360	arg1	weight					333:338	a low molecular weight diepoxy-poly	317:351	a low molecular weight diepoxy-poly(ethylene glycol) (diePEG)	317:377	Chitosan (Ch) was crosslinked with a low molecular weight diepoxy-poly(ethylene glycol) (diePEG), and hydrogel films with different Ch/PEG composition and OPU content were prepared by casting.
33910725	7	49	theme	release	838:844	arg1	kinetics					846:853	release kinetics	838:853	release kinetics	838:853	Swelling characteristics, water vapor transmission rate, and release kinetics demonstrated that these films are adequate for the proposed application.
33375776	9	0	theme	power	1678:1682	arg1	generators					1684:1693	skin-attachable power generators	1662:1693	skin-attachable power generators	1662:1693	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	7	1	theme	rabbit	1249:1254	arg1	skin					1256:1259	rabbit skin	1249:1259	rabbit skin	1249:1259	In addition, a cytotoxicity study and biocompatibility tests on rabbit skin suggested that the DF-CNF composite was biologically safe.
33375776	6	2	theme	DF-CNF	927:932	arg1	TENG					934:937	The DF-CNF TENG	923:937	The DF-CNF TENG	923:937	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	3	3	theme	high	587:590	arg1	area					600:603	high surface area	587:603	high surface area	587:603	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	1	4	theme	significant	296:306	arg1	interest					317:324	attracting significant research interest	285:324	attracting significant research interest	285:324	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	1	4	theme	significant	296:306	arg1	application					126:136	The application	122:136	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body	122:274	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	9	5	theme	tactile	1700:1706	arg1	systems					1717:1723	tactile feedback systems	1700:1723	tactile feedback systems	1700:1723	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	5	6	theme	biocomposite	832:843	arg1	film					845:848	The DF-CNF biocomposite film	821:848	The DF-CNF biocomposite film	821:848	The DF-CNF biocomposite film is mechanically strong, electron-rich, low-cost, and frictionally rough.
33375776	5	6	theme	biocomposite	832:843	arg1	strong					866:871	strong	866:871	strong	866:871	The DF-CNF biocomposite film is mechanically strong, electron-rich, low-cost, and frictionally rough.
33375776	5	6	theme	biocomposite	832:843	arg1	rough					916:920	rough	916:920	rough	916:920	The DF-CNF biocomposite film is mechanically strong, electron-rich, low-cost, and frictionally rough.
33375776	6	7	theme	light-emitting	1162:1175	arg1	diodes					1177:1182	102 light-emitting diodes	1158:1182	102 light-emitting diodes	1158:1182	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	4	8	with	film	805:808	arg1	CNFs					815:818	CNFs	815:818	CNFs	815:818	Hence, DFs were applied to form a tribopositive composite film with CNFs.
33375776	6	9	theme	time-averaged	977:989	arg1	power					991:995	time-averaged power	977:995	time-averaged power of 85.5 mW/m2	977:1009	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	9	10	theme	high	1478:1481	arg1	performance					1490:1500	high output performance	1478:1500	high output performance of biomaterial-based TENGs	1478:1527	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	6	11	theme	V	971:971	arg1	voltage					956:962	an output voltage	946:962	an output voltage of 388 V	946:971	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	6	11	theme	V	971:971	arg1	power					991:995	time-averaged power	977:995	time-averaged power of 85.5 mW/m2	977:1009	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	9	12	dep	monitoring	1644:1653	arg1	masks					1655:1659	masks	1655:1659	masks	1655:1659	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	7	13	from	study	1213:1217	arg1	skin					1256:1259	rabbit skin	1249:1259	rabbit skin	1249:1259	In addition, a cytotoxicity study and biocompatibility tests on rabbit skin suggested that the DF-CNF composite was biologically safe.
33375776	9	14	theme	biomaterial-based	1505:1521	arg1	TENGs					1523:1527	biomaterial-based TENGs	1505:1527	biomaterial-based TENGs	1505:1527	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	6	15	theme	output	949:954	arg1	voltage					956:962	an output voltage	946:962	an output voltage of 388 V	946:971	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	3	16	theme	enhanced	650:657	arg1	capability					677:686	enhanced electron-donating capability	650:686	enhanced electron-donating capability	650:686	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	1	17	theme	biocompatible	159:171	arg1	materials					173:181	biodegradable and biocompatible materials	141:181	biodegradable and biocompatible materials	141:181	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	0	18	theme	Breath	97:102	arg1	Monitoring					104:113	Self-Powered Breath Monitoring	84:113	Self-Powered Breath Monitoring	84:113	Diatom Bio-Silica and Cellulose Nanofibril for Bio-Triboelectric Nanogenerators and Self-Powered Breath Monitoring Masks.
33375776	9	19	theme	diverse	1551:1557	arg1	advantages					1559:1568	the diverse advantages	1547:1568	the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems	1547:1723	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	20	from	advantages	1559:1568	arg1	systems					1717:1723	tactile feedback systems	1700:1723	tactile feedback systems	1700:1723	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	20	from	advantages	1559:1568	arg1	generators					1684:1693	skin-attachable power generators	1662:1693	skin-attachable power generators	1662:1693	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	20	from	advantages	1559:1568	arg1	monitoring					1644:1653	self-powered health monitoring	1624:1653	self-powered health monitoring masks	1624:1659	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	20	from	advantages	1559:1568	arg1	applications					1603:1614	human body-related applications	1584:1614	human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems	1584:1723	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	6	21	theme	mW/m2	1005:1009	arg1	voltage					956:962	an output voltage	946:962	an output voltage of 388 V	946:971	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	6	21	theme	mW/m2	1005:1009	arg1	power					991:995	time-averaged power	977:995	time-averaged power of 85.5 mW/m2	977:1009	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	4	22	theme	tribopositive	781:793	arg1	film					805:808	a tribopositive composite film	779:808	a tribopositive composite film with CNFs	779:818	Hence, DFs were applied to form a tribopositive composite film with CNFs.
33375776	8	23	theme	TENG	1368:1371	arg1	application					1342:1352	a practical application	1330:1352	a practical application of the DF-CNF TENG	1330:1371	Moreover, a practical application of the DF-CNF TENG was examined with a self-powered smart mask for human breathing monitoring.
33375776	9	24	theme	DFs	1577:1579	arg1	advantages					1559:1568	the diverse advantages	1547:1568	the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems	1547:1723	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	6	25	theme	cm2	1080:1082	arg1	area					1068:1071	an efficient contact area	1047:1071	an efficient contact area of 4.9 cm2	1047:1082	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	0	26	theme	Diatom	0:5	arg1	Bio-Silica					7:16	Diatom Bio-Silica	0:16	Diatom Bio-Silica	0:16	Diatom Bio-Silica and Cellulose Nanofibril for Bio-Triboelectric Nanogenerators and Self-Powered Breath Monitoring Masks.
33375776	1	27	theme	research	308:315	arg1	interest					317:324	attracting significant research interest	285:324	attracting significant research interest	285:324	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	1	27	theme	research	308:315	arg1	application					126:136	The application	122:136	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body	122:274	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	9	28	theme	human	1584:1588	arg1	systems					1717:1723	tactile feedback systems	1700:1723	tactile feedback systems	1700:1723	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	28	theme	human	1584:1588	arg1	generators					1684:1693	skin-attachable power generators	1662:1693	skin-attachable power generators	1662:1693	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	28	theme	human	1584:1588	arg1	monitoring					1644:1653	self-powered health monitoring	1624:1653	self-powered health monitoring masks	1624:1659	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	28	theme	human	1584:1588	arg1	applications					1603:1614	human body-related applications	1584:1614	human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems	1584:1723	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	2	29	theme	TENGs	459:463	arg1	performance					411:421	the output performance	400:421	the output performance of cellulose nanofibril (CNF)-based TENGs	400:463	Herein, we report diatom bio-silica as a biomaterial additive to enhance the output performance of cellulose nanofibril (CNF)-based TENGs.
33375776	6	30	theme	contact	1060:1066	arg1	area					1068:1071	an efficient contact area	1047:1071	an efficient contact area of 4.9 cm2	1047:1082	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	8	31	theme	smart	1406:1410	arg1	mask					1412:1415	a self-powered smart mask	1391:1415	a self-powered smart mask for human breathing monitoring	1391:1446	Moreover, a practical application of the DF-CNF TENG was examined with a self-powered smart mask for human breathing monitoring.
33375776	0	32	theme	Bio-Triboelectric	47:63	arg1	Nanogenerators					65:78	Bio-Triboelectric Nanogenerators	47:78	Bio-Triboelectric Nanogenerators	47:78	Diatom Bio-Silica and Cellulose Nanofibril for Bio-Triboelectric Nanogenerators and Self-Powered Breath Monitoring Masks.
33375776	9	33	theme	health	1637:1642	arg1	monitoring					1644:1653	self-powered health monitoring	1624:1653	self-powered health monitoring masks	1624:1659	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	8	34	theme	breathing	1427:1435	arg1	monitoring					1437:1446	human breathing monitoring	1421:1446	human breathing monitoring	1421:1446	Moreover, a practical application of the DF-CNF TENG was examined with a self-powered smart mask for human breathing monitoring.
33375776	7	35	theme	DF-CNF	1280:1285	arg1	composite					1287:1295	the DF-CNF composite	1276:1295	the DF-CNF composite	1276:1295	In addition, a cytotoxicity study and biocompatibility tests on rabbit skin suggested that the DF-CNF composite was biologically safe.
33375776	7	35	theme	DF-CNF	1280:1285	arg1	safe					1314:1317	safe	1314:1317	safe	1314:1317	In addition, a cytotoxicity study and biocompatibility tests on rabbit skin suggested that the DF-CNF composite was biologically safe.
33375776	3	36	theme	roughened	699:707	arg1	surface					709:715	a more roughened surface	692:715	a more roughened surface of the DF-CNF composite film	692:744	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	1	37	theme	human	265:269	arg1	body					271:274	the human body	261:274	the human body	261:274	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	9	38	theme	skin-attachable	1662:1676	arg1	generators					1684:1693	skin-attachable power generators	1662:1693	skin-attachable power generators	1662:1693	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	6	39	theme	generated	1093:1101	arg1	sufficient					1113:1122	sufficient	1113:1122	sufficient	1113:1122	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	6	39	theme	generated	1093:1101	arg1	power					1103:1107	the generated power	1089:1107	the generated power	1089:1107	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	3	40	theme	film	741:744	arg1	surface					709:715	a more roughened surface	692:715	a more roughened surface of the DF-CNF composite film	692:744	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	3	40	theme	film	741:744	arg1	capability					677:686	enhanced electron-donating capability	650:686	enhanced electron-donating capability	650:686	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	3	41	theme	DF-CNF	724:729	arg1	film					741:744	the DF-CNF composite film	720:744	the DF-CNF composite film	720:744	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	1	42	theme	attracting	285:294	arg1	interest					317:324	attracting significant research interest	285:324	attracting significant research interest	285:324	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	1	42	theme	attracting	285:294	arg1	application					126:136	The application	122:136	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body	122:274	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	3	43	theme	three-dimensional	554:570	arg1	structures					572:581	hierarchically porous three-dimensional structures	532:581	hierarchically porous three-dimensional structures	532:581	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	9	44	theme	feedback	1708:1715	arg1	systems					1717:1723	tactile feedback systems	1700:1723	tactile feedback systems	1700:1723	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	6	45	theme	diodes	1177:1182	arg1	illumination					1142:1153	instantaneous illumination	1128:1153	instantaneous illumination of 102 light-emitting diodes	1128:1182	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	7	46	theme	biocompatibility	1223:1238	arg1	tests					1240:1244	a cytotoxicity study and biocompatibility tests	1198:1244	tests	1240:1244	In addition, a cytotoxicity study and biocompatibility tests on rabbit skin suggested that the DF-CNF composite was biologically safe.
33375776	2	47	theme	diatom	345:350	arg1	bio-silica					352:361	diatom bio-silica	345:361	diatom bio-silica	345:361	Herein, we report diatom bio-silica as a biomaterial additive to enhance the output performance of cellulose nanofibril (CNF)-based TENGs.
33375776	2	47	theme	diatom	345:350	arg1	biomaterial					368:378	biomaterial	368:378	biomaterial	368:378	Herein, we report diatom bio-silica as a biomaterial additive to enhance the output performance of cellulose nanofibril (CNF)-based TENGs.
33375776	3	48	theme	surface	592:598	arg1	area					600:603	high surface area	587:603	high surface area	587:603	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	1	49	theme	harvesting	227:236	arg1	energy					238:243	harvesting energy	227:243	harvesting energy from motions of the human body	227:274	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	9	50	theme	output	1483:1488	arg1	performance					1490:1500	high output performance	1478:1500	high output performance of biomaterial-based TENGs	1478:1527	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	3	51	theme	hydrogen	611:618	arg1	bonds					620:624	hydrogen bonds	611:624	hydrogen bonds	611:624	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	1	52	from	motions	250:256	arg1	energy					238:243	harvesting energy	227:243	harvesting energy from motions of the human body	227:274	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	6	53	with	mode	1037:1040	arg1	area					1068:1071	an efficient contact area	1047:1071	an efficient contact area of 4.9 cm2	1047:1082	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	9	54	theme	TENGs	1523:1527	arg1	performance					1490:1500	high output performance	1478:1500	high output performance of biomaterial-based TENGs	1478:1527	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	55	from	applications	1603:1614	arg1	advantages					1559:1568	the diverse advantages	1547:1568	the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems	1547:1723	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	7	56	from	tests	1240:1244	arg1	skin					1256:1259	rabbit skin	1249:1259	rabbit skin	1249:1259	In addition, a cytotoxicity study and biocompatibility tests on rabbit skin suggested that the DF-CNF composite was biologically safe.
33375776	0	57	theme	Self-Powered	84:95	arg1	Monitoring					104:113	Self-Powered Breath Monitoring	84:113	Self-Powered Breath Monitoring	84:113	Diatom Bio-Silica and Cellulose Nanofibril for Bio-Triboelectric Nanogenerators and Self-Powered Breath Monitoring Masks.
33375776	1	58	theme	materials	173:181	arg1	interest					317:324	attracting significant research interest	285:324	attracting significant research interest	285:324	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	1	58	theme	materials	173:181	arg1	application					126:136	The application	122:136	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body	122:274	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	1	59	theme	biodegradable	141:153	arg1	materials					173:181	biodegradable and biocompatible materials	141:181	biodegradable and biocompatible materials	141:181	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	6	60	theme	contact-separation	1018:1035	arg1	mode					1037:1040	the contact-separation mode	1014:1040	the contact-separation mode with an efficient contact area of 4.9 cm2	1014:1082	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	3	61	contain	having	525:530	arg1	frustules					473:481	Diatom frustules	466:481	Diatom frustules (DFs)	466:487	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	3	61	contain	having	525:530	arg2	structures					572:581	hierarchically porous three-dimensional structures	532:581	hierarchically porous three-dimensional structures	532:581	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	3	61	contain	having	525:530	arg1	bio-silica					514:523	tribopositive bio-silica	500:523	tribopositive bio-silica having hierarchically porous three-dimensional structures	500:581	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	1	62	theme	triboelectric	186:198	arg1	TENGs					216:220	TENGs	216:220	TENGs	216:220	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	1	62	theme	triboelectric	186:198	arg1	nanogenerators					200:213	triboelectric nanogenerators	186:213	triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body	186:274	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
33375776	9	63	from	DFs	1577:1579	arg1	systems					1717:1723	tactile feedback systems	1700:1723	tactile feedback systems	1700:1723	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	63	from	DFs	1577:1579	arg1	generators					1684:1693	skin-attachable power generators	1662:1693	skin-attachable power generators	1662:1693	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	63	from	DFs	1577:1579	arg1	monitoring					1644:1653	self-powered health monitoring	1624:1653	self-powered health monitoring masks	1624:1659	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	63	from	DFs	1577:1579	arg1	applications					1603:1614	human body-related applications	1584:1614	human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems	1584:1723	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	8	64	theme	practical	1332:1340	arg1	application					1342:1352	a practical application	1330:1352	a practical application of the DF-CNF TENG	1330:1371	Moreover, a practical application of the DF-CNF TENG was examined with a self-powered smart mask for human breathing monitoring.
33375776	7	65	theme	cytotoxicity	1200:1211	arg1	study					1213:1217	a cytotoxicity study and biocompatibility tests	1198:1244	study	1213:1217	In addition, a cytotoxicity study and biocompatibility tests on rabbit skin suggested that the DF-CNF composite was biologically safe.
33375776	8	66	theme	DF-CNF	1361:1366	arg1	TENG					1368:1371	the DF-CNF TENG	1357:1371	the DF-CNF TENG	1357:1371	Moreover, a practical application of the DF-CNF TENG was examined with a self-powered smart mask for human breathing monitoring.
33375776	3	67	theme	Diatom	466:471	arg1	DFs					484:486	DFs	484:486	DFs	484:486	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	3	67	theme	Diatom	466:471	arg1	bio-silica					514:523	tribopositive bio-silica	500:523	tribopositive bio-silica having hierarchically porous three-dimensional structures	500:581	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	3	67	theme	Diatom	466:471	arg1	frustules					473:481	Diatom frustules	466:481	Diatom frustules (DFs)	466:487	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	5	68	theme	DF-CNF	825:830	arg1	film					845:848	The DF-CNF biocomposite film	821:848	The DF-CNF biocomposite film	821:848	The DF-CNF biocomposite film is mechanically strong, electron-rich, low-cost, and frictionally rough.
33375776	5	68	theme	DF-CNF	825:830	arg1	strong					866:871	strong	866:871	strong	866:871	The DF-CNF biocomposite film is mechanically strong, electron-rich, low-cost, and frictionally rough.
33375776	5	68	theme	DF-CNF	825:830	arg1	rough					916:920	rough	916:920	rough	916:920	The DF-CNF biocomposite film is mechanically strong, electron-rich, low-cost, and frictionally rough.
33375776	2	69	theme	output	404:409	arg1	performance					411:421	the output performance	400:421	the output performance of cellulose nanofibril (CNF)-based TENGs	400:463	Herein, we report diatom bio-silica as a biomaterial additive to enhance the output performance of cellulose nanofibril (CNF)-based TENGs.
33375776	0	70	theme	Cellulose	22:30	arg1	Nanofibril					32:41	Cellulose Nanofibril	22:41	Cellulose Nanofibril	22:41	Diatom Bio-Silica and Cellulose Nanofibril for Bio-Triboelectric Nanogenerators and Self-Powered Breath Monitoring Masks.
33375776	9	71	theme	body-related	1590:1601	arg1	systems					1717:1723	tactile feedback systems	1700:1723	tactile feedback systems	1700:1723	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	71	theme	body-related	1590:1601	arg1	generators					1684:1693	skin-attachable power generators	1662:1693	skin-attachable power generators	1662:1693	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	71	theme	body-related	1590:1601	arg1	monitoring					1644:1653	self-powered health monitoring	1624:1653	self-powered health monitoring masks	1624:1659	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	9	71	theme	body-related	1590:1601	arg1	applications					1603:1614	human body-related applications	1584:1614	human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems	1584:1723	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	2	72	theme	-based	452:457	arg1	TENGs					459:463	cellulose nanofibril (CNF)-based TENGs	426:463	cellulose nanofibril (CNF)-based TENGs	426:463	Herein, we report diatom bio-silica as a biomaterial additive to enhance the output performance of cellulose nanofibril (CNF)-based TENGs.
33375776	3	73	contain	have	606:609	arg1	bio-silica					514:523	tribopositive bio-silica	500:523	tribopositive bio-silica having hierarchically porous three-dimensional structures	500:581	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	3	73	contain	have	606:609	arg1	DFs					484:486	DFs	484:486	DFs	484:486	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	3	73	contain	have	606:609	arg2	bonds					620:624	hydrogen bonds	611:624	hydrogen bonds	611:624	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	3	73	contain	have	606:609	arg1	frustules					473:481	Diatom frustules	466:481	Diatom frustules (DFs)	466:487	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	6	74	theme	efficient	1050:1058	arg1	area					1068:1071	an efficient contact area	1047:1071	an efficient contact area of 4.9 cm2	1047:1082	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	3	75	theme	electron-donating	659:675	arg1	capability					677:686	enhanced electron-donating capability	650:686	enhanced electron-donating capability	650:686	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	8	76	theme	self-powered	1393:1404	arg1	mask					1412:1415	a self-powered smart mask	1391:1415	a self-powered smart mask for human breathing monitoring	1391:1446	Moreover, a practical application of the DF-CNF TENG was examined with a self-powered smart mask for human breathing monitoring.
33375776	9	77	theme	self-powered	1624:1635	arg1	monitoring					1644:1653	self-powered health monitoring	1624:1653	self-powered health monitoring masks	1624:1659	This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.
33375776	6	78	theme	instantaneous	1128:1140	arg1	illumination					1142:1153	instantaneous illumination	1128:1153	instantaneous illumination of 102 light-emitting diodes	1128:1182	The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes.
33375776	3	79	theme	tribopositive	500:512	arg1	frustules					473:481	Diatom frustules	466:481	Diatom frustules (DFs)	466:487	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	3	79	theme	tribopositive	500:512	arg1	bio-silica					514:523	tribopositive bio-silica	500:523	tribopositive bio-silica having hierarchically porous three-dimensional structures	500:581	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	4	80	theme	composite	795:803	arg1	film					805:808	a tribopositive composite film	779:808	a tribopositive composite film with CNFs	779:818	Hence, DFs were applied to form a tribopositive composite film with CNFs.
33375776	8	81	theme	human	1421:1425	arg1	monitoring					1437:1446	human breathing monitoring	1421:1446	human breathing monitoring	1421:1446	Moreover, a practical application of the DF-CNF TENG was examined with a self-powered smart mask for human breathing monitoring.
33375776	3	82	theme	composite	731:739	arg1	film					741:744	the DF-CNF composite film	720:744	the DF-CNF composite film	720:744	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	5	83	dep	strong	866:871	arg1	film					845:848	The DF-CNF biocomposite film	821:848	The DF-CNF biocomposite film	821:848	The DF-CNF biocomposite film is mechanically strong, electron-rich, low-cost, and frictionally rough.
33375776	5	83	dep	strong	866:871	arg1	rough					916:920	rough	916:920	rough	916:920	The DF-CNF biocomposite film is mechanically strong, electron-rich, low-cost, and frictionally rough.
33375776	5	83	dep	strong	866:871	arg1	strong					866:871	strong	866:871	strong	866:871	The DF-CNF biocomposite film is mechanically strong, electron-rich, low-cost, and frictionally rough.
33375776	3	84	theme	porous	547:552	arg1	structures					572:581	hierarchically porous three-dimensional structures	532:581	hierarchically porous three-dimensional structures	532:581	Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film.
33375776	1	85	theme	body	271:274	arg1	motions					250:256	motions	250:256	motions of the human body	250:274	The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest.
34147772	4	0	theme	genes	859:863	arg1	genes					859:863	shikimic acid metabolism genes	834:863	shikimic acid metabolism genes	834:863	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	4	0	theme	genes	859:863	arg1	amounts					823:829	the bacterial amounts	809:829	the bacterial amounts of shikimic acid metabolism genes	809:863	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	4	0	theme	genes	859:863	arg1	correlation					873:883	the correlation	869:883	the correlation between HA components and shikimic acid metabolism genes	869:940	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	2	1	theme	Fenton	332:337	arg1	reactions					339:347	Fenton reactions	332:347	Fenton reactions	332:347	Rice straw was pretreated by Fenton reactions and then inoculated during composting, which was set up CK (control), FeW (Fenton pretreatment) and FeWI (Fenton pretreatment + functional bacterial agents).
34147772	2	2	theme	Fenton	424:429	arg1	FeW					419:421	FeW	419:421	FeW	419:421	Rice straw was pretreated by Fenton reactions and then inoculated during composting, which was set up CK (control), FeW (Fenton pretreatment) and FeWI (Fenton pretreatment + functional bacterial agents).
34147772	2	2	theme	Fenton	424:429	arg1	pretreatment					431:442	Fenton pretreatment	424:442	Fenton pretreatment	424:442	Rice straw was pretreated by Fenton reactions and then inoculated during composting, which was set up CK (control), FeW (Fenton pretreatment) and FeWI (Fenton pretreatment + functional bacterial agents).
34147772	5	3	theme	HA	1112:1113	arg1	components					1115:1124	HA components	1112:1124	HA components	1112:1124	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	4	4	theme	metabolism	848:857	arg1	genes					859:863	shikimic acid metabolism genes	834:863	shikimic acid metabolism genes	834:863	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	1	5	theme	study	155:159	arg1	aims					142:145	The aims	138:145	The aims of this study	138:159	The aims of this study were to identify the driving factors of humic acid (HA) during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	1	6	theme	rice	224:227	arg1	composting					235:244	rice straw composting	224:244	rice straw composting based on Fenton pretreatment with bacterial inoculation	224:300	The aims of this study were to identify the driving factors of humic acid (HA) during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	0	7	theme	Fenton	90:95	arg1	pretreatment					97:108	Fenton pretreatment	90:108	Fenton pretreatment with bacterial inoculation	90:135	Identifying driving factors of humic acid formation during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	1	8	with	pretreatment	262:273	arg1	inoculation					290:300	bacterial inoculation	280:300	bacterial inoculation	280:300	The aims of this study were to identify the driving factors of humic acid (HA) during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	1	9	theme	straw	229:233	arg1	composting					235:244	rice straw composting	224:244	rice straw composting based on Fenton pretreatment with bacterial inoculation	224:300	The aims of this study were to identify the driving factors of humic acid (HA) during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	5	10	theme	functional	958:967	arg1	factors					996:1002	core driving factors	983:1002	core driving factors	983:1002	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	5	10	theme	functional	958:967	arg1	bacteria					969:976	the functional bacteria	954:976	the functional bacteria	954:976	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	3	11	theme	bacterial	695:703	arg1	diversity					705:713	bacterial diversity	695:713	bacterial diversity	695:713	Results indicated that Fenton pretreatment and inoculation of functional bacteria increased the concentration of HA components, which was due to that bacterial composition was changed and bacterial diversity was decreased.
34147772	4	12	theme	Fenton	740:745	arg1	pretreatment					747:758	Fenton pretreatment	740:758	Fenton pretreatment	740:758	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	0	13	theme	driving	12:18	arg1	factors					20:26	Identifying driving factors	0:26	Identifying driving factors of humic acid formation during rice straw	0:68	Identifying driving factors of humic acid formation during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	4	14	theme	acid	843:846	arg1	genes					859:863	shikimic acid metabolism genes	834:863	shikimic acid metabolism genes	834:863	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	0	15	with	pretreatment	97:108	arg1	inoculation					125:135	bacterial inoculation	115:135	bacterial inoculation	115:135	Identifying driving factors of humic acid formation during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	0	16	theme	Identifying	0:10	arg1	factors					20:26	Identifying driving factors	0:26	Identifying driving factors of humic acid formation during rice straw	0:68	Identifying driving factors of humic acid formation during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	2	17	theme	pretreatment + functional	462:486	arg1	agents					498:503	pretreatment + functional bacterial agents	462:503	Fenton pretreatment + functional bacterial agents	455:503	Rice straw was pretreated by Fenton reactions and then inoculated during composting, which was set up CK (control), FeW (Fenton pretreatment) and FeWI (Fenton pretreatment + functional bacterial agents).
34147772	0	18	dep	composting	70:79	arg1	based					81:85	based	81:85	composting based on Fenton pretreatment with bacterial inoculation	70:135	Identifying driving factors of humic acid formation during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	4	19	theme	functional	779:788	arg1	bacteria					790:797	functional bacteria	779:797	functional bacteria	779:797	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	4	20	theme	shikimic	911:918	arg1	genes					936:940	shikimic acid metabolism genes	911:940	shikimic acid metabolism genes	911:940	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	1	21	theme	driving	182:188	arg1	factors					190:196	the driving factors	178:196	the driving factors of humic acid (HA)	178:215	The aims of this study were to identify the driving factors of humic acid (HA) during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	3	22	theme	Fenton	530:535	arg1	pretreatment					537:548	Fenton pretreatment	530:548	Fenton pretreatment	530:548	Results indicated that Fenton pretreatment and inoculation of functional bacteria increased the concentration of HA components, which was due to that bacterial composition was changed and bacterial diversity was decreased.
34147772	1	23	theme	Fenton	255:260	arg1	pretreatment					262:273	Fenton pretreatment	255:273	Fenton pretreatment with bacterial inoculation	255:300	The aims of this study were to identify the driving factors of humic acid (HA) during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	0	24	theme	bacterial	115:123	arg1	inoculation					125:135	bacterial inoculation	115:135	bacterial inoculation	115:135	Identifying driving factors of humic acid formation during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	3	25	theme	HA	620:621	arg1	components					623:632	HA components	620:632	HA components	620:632	Results indicated that Fenton pretreatment and inoculation of functional bacteria increased the concentration of HA components, which was due to that bacterial composition was changed and bacterial diversity was decreased.
34147772	0	26	theme	acid	37:40	arg1	formation					42:50	humic acid formation	31:50	humic acid formation during rice straw	31:68	Identifying driving factors of humic acid formation during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	4	27	theme	metabolism	925:934	arg1	genes					936:940	shikimic acid metabolism genes	911:940	shikimic acid metabolism genes	911:940	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	3	28	theme	components	623:632	arg1	concentration					603:615	the concentration	599:615	the concentration of HA components	599:632	Results indicated that Fenton pretreatment and inoculation of functional bacteria increased the concentration of HA components, which was due to that bacterial composition was changed and bacterial diversity was decreased.
34147772	4	29	theme	acid	920:923	arg1	genes					936:940	shikimic acid metabolism genes	911:940	shikimic acid metabolism genes	911:940	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	3	30	dep	increased	589:597	arg1	due					645:647	due	645:647	due	645:647	Results indicated that Fenton pretreatment and inoculation of functional bacteria increased the concentration of HA components, which was due to that bacterial composition was changed and bacterial diversity was decreased.
34147772	0	31	theme	humic	31:35	arg1	formation					42:50	humic acid formation	31:50	humic acid formation during rice straw	31:68	Identifying driving factors of humic acid formation during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	2	32	theme	bacterial	488:496	arg1	agents					498:503	pretreatment + functional bacterial agents	462:503	Fenton pretreatment + functional bacterial agents	455:503	Rice straw was pretreated by Fenton reactions and then inoculated during composting, which was set up CK (control), FeW (Fenton pretreatment) and FeWI (Fenton pretreatment + functional bacterial agents).
34147772	5	33	theme	key	1058:1060	arg1	factors					1076:1082	key environmental factors	1058:1082	key environmental factors	1058:1082	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	4	34	theme	bacteria	790:797	arg1	inoculation					764:774	inoculation	764:774	inoculation	764:774	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	4	34	theme	bacteria	790:797	arg1	pretreatment					747:758	Fenton pretreatment	740:758	Fenton pretreatment	740:758	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	1	35	theme	humic	201:205	arg1	HA					213:214	HA	213:214	HA	213:214	The aims of this study were to identify the driving factors of humic acid (HA) during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	1	35	theme	humic	201:205	arg1	acid					207:210	humic acid	201:210	humic acid (HA)	201:215	The aims of this study were to identify the driving factors of humic acid (HA) during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	1	36	theme	bacterial	280:288	arg1	inoculation					290:300	bacterial inoculation	280:300	bacterial inoculation	280:300	The aims of this study were to identify the driving factors of humic acid (HA) during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	5	37	theme	environmental	1062:1074	arg1	factors					1076:1082	key environmental factors	1058:1082	key environmental factors	1058:1082	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	4	38	theme	bacterial	813:821	arg1	genes					859:863	shikimic acid metabolism genes	834:863	shikimic acid metabolism genes	834:863	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	4	38	theme	bacterial	813:821	arg1	amounts					823:829	the bacterial amounts	809:829	the bacterial amounts of shikimic acid metabolism genes	809:863	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	4	39	theme	shikimic	834:841	arg1	genes					859:863	shikimic acid metabolism genes	834:863	shikimic acid metabolism genes	834:863	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	0	40	theme	formation	42:50	arg1	factors					20:26	Identifying driving factors	0:26	Identifying driving factors of humic acid formation during rice straw	0:68	Identifying driving factors of humic acid formation during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	5	41	theme	core	983:986	arg1	factors					996:1002	core driving factors	983:1002	core driving factors	983:1002	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	5	41	theme	core	983:986	arg1	cellulose					1021:1029	cellulose	1021:1029	cellulose	1021:1029	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	5	41	theme	core	983:986	arg1	bacteria					969:976	the functional bacteria	954:976	the functional bacteria	954:976	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	5	41	theme	core	983:986	arg1	NH4--N					1009:1014	NH4--N	1009:1014	NH4--N	1009:1014	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	5	41	theme	core	983:986	arg1	diversity					1045:1053	bacterial diversity	1035:1053	bacterial diversity	1035:1053	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	5	41	theme	core	983:986	arg1	pH					1017:1018	pH	1017:1018	pH	1017:1018	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	5	42	theme	components	1115:1124	arg1	formation					1099:1107	the formation	1095:1107	the formation of HA components	1095:1124	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	1	43	theme	acid	207:210	arg1	factors					190:196	the driving factors	178:196	the driving factors of humic acid (HA)	178:215	The aims of this study were to identify the driving factors of humic acid (HA) during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	4	44	theme	HA	893:894	arg1	components					896:905	HA components	893:905	HA components	893:905	Moreover, Fenton pretreatment and inoculation of functional bacteria increased the bacterial amounts of shikimic acid metabolism genes and the correlation between HA components and shikimic acid metabolism genes.
34147772	5	45	theme	driving	988:994	arg1	factors					996:1002	core driving factors	983:1002	core driving factors	983:1002	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	5	45	theme	driving	988:994	arg1	cellulose					1021:1029	cellulose	1021:1029	cellulose	1021:1029	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	5	45	theme	driving	988:994	arg1	bacteria					969:976	the functional bacteria	954:976	the functional bacteria	954:976	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	5	45	theme	driving	988:994	arg1	NH4--N					1009:1014	NH4--N	1009:1014	NH4--N	1009:1014	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	5	45	theme	driving	988:994	arg1	diversity					1045:1053	bacterial diversity	1035:1053	bacterial diversity	1035:1053	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	5	45	theme	driving	988:994	arg1	pH					1017:1018	pH	1017:1018	pH	1017:1018	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	2	46	dep	Fenton	455:460	arg1	agents					498:503	pretreatment + functional bacterial agents	462:503	Fenton pretreatment + functional bacterial agents	455:503	Rice straw was pretreated by Fenton reactions and then inoculated during composting, which was set up CK (control), FeW (Fenton pretreatment) and FeWI (Fenton pretreatment + functional bacterial agents).
34147772	2	47	theme	Rice	303:306	arg1	straw					308:312	Rice straw	303:312	Rice straw	303:312	Rice straw was pretreated by Fenton reactions and then inoculated during composting, which was set up CK (control), FeW (Fenton pretreatment) and FeWI (Fenton pretreatment + functional bacterial agents).
34147772	5	48	theme	bacterial	1035:1043	arg1	factors					996:1002	core driving factors	983:1002	core driving factors	983:1002	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	5	48	theme	bacterial	1035:1043	arg1	diversity					1045:1053	bacterial diversity	1035:1053	bacterial diversity	1035:1053	Therefore, the functional bacteria were core driving factors, and NH4--N, pH, cellulose and bacterial diversity as key environmental factors to promote the formation of HA components.
34147772	3	49	theme	functional	569:578	arg1	bacteria					580:587	functional bacteria	569:587	functional bacteria	569:587	Results indicated that Fenton pretreatment and inoculation of functional bacteria increased the concentration of HA components, which was due to that bacterial composition was changed and bacterial diversity was decreased.
34147772	0	50	theme	rice	59:62	arg1	straw					64:68	rice straw	59:68	rice straw	59:68	Identifying driving factors of humic acid formation during rice straw composting based on Fenton pretreatment with bacterial inoculation.
34147772	3	51	theme	bacterial	657:665	arg1	composition					667:677	bacterial composition	657:677	bacterial composition	657:677	Results indicated that Fenton pretreatment and inoculation of functional bacteria increased the concentration of HA components, which was due to that bacterial composition was changed and bacterial diversity was decreased.
34147772	3	52	theme	bacteria	580:587	arg1	inoculation					554:564	inoculation	554:564	inoculation	554:564	Results indicated that Fenton pretreatment and inoculation of functional bacteria increased the concentration of HA components, which was due to that bacterial composition was changed and bacterial diversity was decreased.
34147772	3	52	theme	bacteria	580:587	arg1	pretreatment					537:548	Fenton pretreatment	530:548	Fenton pretreatment	530:548	Results indicated that Fenton pretreatment and inoculation of functional bacteria increased the concentration of HA components, which was due to that bacterial composition was changed and bacterial diversity was decreased.
34742435	2	0	used	used	246:249	arg2	Octadecylamine					195:208	Octadecylamine	195:208	Octadecylamine	195:208	Octadecylamine, a low surface energy material, was used to provide hydrophobic alkyl long chains.
34742435	2	0	used	used	246:249	arg2	material					232:239	a low surface energy material	211:239	a low surface energy material	211:239	Octadecylamine, a low surface energy material, was used to provide hydrophobic alkyl long chains.
34742435	4	1	theme	reaction	553:560	arg1	time					562:565	reaction time	553:565	reaction time	553:565	The effects of reagent concentration, reaction temperature, and reaction time on hydrophobicity were then investigated.
34742435	7	2	theme	high-temperature	1054:1069	arg1	resistance					1071:1080	high-temperature resistance	1054:1080	high-temperature resistance	1054:1080	Thus, the green preparation of superhydrophobic films with high-temperature resistance and wear resistance was realized, which contributed to the high-value utilization of nanocellulose.
34742435	3	3	theme	adhesive	370:377	arg1	substance					379:387	an adhesive substance	367:387	an adhesive substance	367:387	Polydopamine was produced by dopamine under alkaline conditions, creating an adhesive substance, which reinforced the hydrophobic long chains and increased the surface roughness of nanocellulose.
34742435	6	4	theme	smaller	874:880	arg1	size					891:894	a smaller particle size	872:894	a smaller particle size	872:894	Scanning electron microscope images revealed that the modified nanocellulose had a smaller particle size and more uniform distribution, which effectively improved the hydrophobicity of the nanocellulose.
34742435	4	5	theme	concentration	512:524	arg1	effects					493:499	The effects	489:499	The effects of reagent concentration, reaction temperature, and reaction time on hydrophobicity	489:583	The effects of reagent concentration, reaction temperature, and reaction time on hydrophobicity were then investigated.
34742435	5	6	theme	membrane	766:773	arg1	angle					734:738	the contact angle	722:738	the contact angle of the obtained composite membrane	722:773	The results showed that with a 1:1 mass ratio of nanocellulose to octadecylamine, and reacting at 60 °C for 4 h, the contact angle of the obtained composite membrane reached 168.2°.
34742435	7	7	theme	films	1043:1047	arg1	preparation					1011:1021	the green preparation	1001:1021	the green preparation of superhydrophobic films with high-temperature resistance and wear resistance	1001:1100	Thus, the green preparation of superhydrophobic films with high-temperature resistance and wear resistance was realized, which contributed to the high-value utilization of nanocellulose.
34742435	3	8	theme	hydrophobic	411:421	arg1	chains					428:433	the hydrophobic long chains	407:433	the hydrophobic long chains	407:433	Polydopamine was produced by dopamine under alkaline conditions, creating an adhesive substance, which reinforced the hydrophobic long chains and increased the surface roughness of nanocellulose.
34742435	4	9	theme	temperature	536:546	arg1	effects					493:499	The effects	489:499	The effects of reagent concentration, reaction temperature, and reaction time on hydrophobicity	489:583	The effects of reagent concentration, reaction temperature, and reaction time on hydrophobicity were then investigated.
34742435	6	10	theme	microscope	809:818	arg1	images					820:825	Scanning electron microscope images	791:825	Scanning electron microscope images	791:825	Scanning electron microscope images revealed that the modified nanocellulose had a smaller particle size and more uniform distribution, which effectively improved the hydrophobicity of the nanocellulose.
34742435	5	11	theme	nanocellulose	658:670	arg1	ratio					649:653	a 1:1 mass ratio	638:653	a 1:1 mass ratio of nanocellulose to octadecylamine	638:688	The results showed that with a 1:1 mass ratio of nanocellulose to octadecylamine, and reacting at 60 °C for 4 h, the contact angle of the obtained composite membrane reached 168.2°.
34742435	4	12	theme	reaction	527:534	arg1	temperature					536:546	reaction temperature	527:546	reaction temperature	527:546	The effects of reagent concentration, reaction temperature, and reaction time on hydrophobicity were then investigated.
34742435	6	13	theme	modified	845:852	arg1	nanocellulose					854:866	the modified nanocellulose	841:866	the modified nanocellulose	841:866	Scanning electron microscope images revealed that the modified nanocellulose had a smaller particle size and more uniform distribution, which effectively improved the hydrophobicity of the nanocellulose.
34742435	3	14	theme	long	423:426	arg1	chains					428:433	the hydrophobic long chains	407:433	the hydrophobic long chains	407:433	Polydopamine was produced by dopamine under alkaline conditions, creating an adhesive substance, which reinforced the hydrophobic long chains and increased the surface roughness of nanocellulose.
34742435	7	15	theme	nanocellulose	1167:1179	arg1	utilization					1152:1162	the high-value utilization	1137:1162	the high-value utilization of nanocellulose	1137:1179	Thus, the green preparation of superhydrophobic films with high-temperature resistance and wear resistance was realized, which contributed to the high-value utilization of nanocellulose.
34742435	7	16	theme	green	1005:1009	arg1	preparation					1011:1021	the green preparation	1001:1021	the green preparation of superhydrophobic films with high-temperature resistance and wear resistance	1001:1100	Thus, the green preparation of superhydrophobic films with high-temperature resistance and wear resistance was realized, which contributed to the high-value utilization of nanocellulose.
34742435	1	17	theme	super-hydrophobic	103:119	arg1	films					135:139	super-hydrophobic nanocellulose films	103:139	super-hydrophobic nanocellulose films using a non-toxic octadecylamine/polydopamine system	103:192	We prepared super-hydrophobic nanocellulose films using a non-toxic octadecylamine/polydopamine system.
34742435	3	18	theme	nanocellulose	474:486	arg1	roughness					461:469	the surface roughness	449:469	the surface roughness of nanocellulose	449:486	Polydopamine was produced by dopamine under alkaline conditions, creating an adhesive substance, which reinforced the hydrophobic long chains and increased the surface roughness of nanocellulose.
34742435	0	19	theme	Superhydrophobic	0:15	arg1	modification					17:28	Superhydrophobic modification	0:28	Superhydrophobic modification of nanocellulose	0:45	Superhydrophobic modification of nanocellulose based on an octadecylamine/dopamine system.
34742435	6	20	theme	uniform	905:911	arg1	distribution					913:924	more uniform distribution	900:924	more uniform distribution	900:924	Scanning electron microscope images revealed that the modified nanocellulose had a smaller particle size and more uniform distribution, which effectively improved the hydrophobicity of the nanocellulose.
34742435	5	21	theme	1:1	640:642	arg1	ratio					649:653	a 1:1 mass ratio	638:653	a 1:1 mass ratio of nanocellulose to octadecylamine	638:688	The results showed that with a 1:1 mass ratio of nanocellulose to octadecylamine, and reacting at 60 °C for 4 h, the contact angle of the obtained composite membrane reached 168.2°.
34742435	1	22	theme	nanocellulose	121:133	arg1	films					135:139	super-hydrophobic nanocellulose films	103:139	super-hydrophobic nanocellulose films using a non-toxic octadecylamine/polydopamine system	103:192	We prepared super-hydrophobic nanocellulose films using a non-toxic octadecylamine/polydopamine system.
34742435	0	23	theme	nanocellulose	33:45	arg1	modification					17:28	Superhydrophobic modification	0:28	Superhydrophobic modification of nanocellulose	0:45	Superhydrophobic modification of nanocellulose based on an octadecylamine/dopamine system.
34742435	5	24	theme	mass	644:647	arg1	ratio					649:653	a 1:1 mass ratio	638:653	a 1:1 mass ratio of nanocellulose to octadecylamine	638:688	The results showed that with a 1:1 mass ratio of nanocellulose to octadecylamine, and reacting at 60 °C for 4 h, the contact angle of the obtained composite membrane reached 168.2°.
34742435	7	25	theme	superhydrophobic	1026:1041	arg1	films					1043:1047	superhydrophobic films	1026:1047	superhydrophobic films with high-temperature resistance and wear resistance	1026:1100	Thus, the green preparation of superhydrophobic films with high-temperature resistance and wear resistance was realized, which contributed to the high-value utilization of nanocellulose.
34742435	7	26	theme	wear	1086:1089	arg1	resistance					1091:1100	wear resistance	1086:1100	wear resistance	1086:1100	Thus, the green preparation of superhydrophobic films with high-temperature resistance and wear resistance was realized, which contributed to the high-value utilization of nanocellulose.
34742435	4	27	theme	reagent	504:510	arg1	concentration					512:524	reagent concentration	504:524	reagent concentration	504:524	The effects of reagent concentration, reaction temperature, and reaction time on hydrophobicity were then investigated.
34742435	6	28	theme	nanocellulose	980:992	arg1	hydrophobicity					958:971	the hydrophobicity	954:971	the hydrophobicity of the nanocellulose	954:992	Scanning electron microscope images revealed that the modified nanocellulose had a smaller particle size and more uniform distribution, which effectively improved the hydrophobicity of the nanocellulose.
34742435	5	29	theme	obtained	747:754	arg1	membrane					766:773	the obtained composite membrane	743:773	the obtained composite membrane	743:773	The results showed that with a 1:1 mass ratio of nanocellulose to octadecylamine, and reacting at 60 °C for 4 h, the contact angle of the obtained composite membrane reached 168.2°.
34742435	2	30	theme	energy	225:230	arg1	Octadecylamine					195:208	Octadecylamine	195:208	Octadecylamine	195:208	Octadecylamine, a low surface energy material, was used to provide hydrophobic alkyl long chains.
34742435	2	30	theme	energy	225:230	arg1	material					232:239	a low surface energy material	211:239	a low surface energy material	211:239	Octadecylamine, a low surface energy material, was used to provide hydrophobic alkyl long chains.
34742435	2	31	theme	long	280:283	arg1	chains					285:290	hydrophobic alkyl long chains	262:290	hydrophobic alkyl long chains	262:290	Octadecylamine, a low surface energy material, was used to provide hydrophobic alkyl long chains.
34742435	5	32	theme	composite	756:764	arg1	membrane					766:773	the obtained composite membrane	743:773	the obtained composite membrane	743:773	The results showed that with a 1:1 mass ratio of nanocellulose to octadecylamine, and reacting at 60 °C for 4 h, the contact angle of the obtained composite membrane reached 168.2°.
34742435	2	33	theme	surface	217:223	arg1	Octadecylamine					195:208	Octadecylamine	195:208	Octadecylamine	195:208	Octadecylamine, a low surface energy material, was used to provide hydrophobic alkyl long chains.
34742435	2	33	theme	surface	217:223	arg1	material					232:239	a low surface energy material	211:239	a low surface energy material	211:239	Octadecylamine, a low surface energy material, was used to provide hydrophobic alkyl long chains.
34742435	2	34	theme	alkyl	274:278	arg1	chains					285:290	hydrophobic alkyl long chains	262:290	hydrophobic alkyl long chains	262:290	Octadecylamine, a low surface energy material, was used to provide hydrophobic alkyl long chains.
34742435	0	35	theme	octadecylamine/dopamine	59:81	arg1	system					83:88	an octadecylamine/dopamine system	56:88	an octadecylamine/dopamine system	56:88	Superhydrophobic modification of nanocellulose based on an octadecylamine/dopamine system.
34742435	4	36	from	effects	493:499	arg1	hydrophobicity					570:583	hydrophobicity	570:583	hydrophobicity	570:583	The effects of reagent concentration, reaction temperature, and reaction time on hydrophobicity were then investigated.
34742435	2	37	theme	low	213:215	arg1	Octadecylamine					195:208	Octadecylamine	195:208	Octadecylamine	195:208	Octadecylamine, a low surface energy material, was used to provide hydrophobic alkyl long chains.
34742435	2	37	theme	low	213:215	arg1	material					232:239	a low surface energy material	211:239	a low surface energy material	211:239	Octadecylamine, a low surface energy material, was used to provide hydrophobic alkyl long chains.
34742435	2	38	theme	hydrophobic	262:272	arg1	chains					285:290	hydrophobic alkyl long chains	262:290	hydrophobic alkyl long chains	262:290	Octadecylamine, a low surface energy material, was used to provide hydrophobic alkyl long chains.
34742435	5	39	theme	contact	726:732	arg1	angle					734:738	the contact angle	722:738	the contact angle of the obtained composite membrane	722:773	The results showed that with a 1:1 mass ratio of nanocellulose to octadecylamine, and reacting at 60 °C for 4 h, the contact angle of the obtained composite membrane reached 168.2°.
34742435	7	40	theme	high-value	1141:1150	arg1	utilization					1152:1162	the high-value utilization	1137:1162	the high-value utilization of nanocellulose	1137:1179	Thus, the green preparation of superhydrophobic films with high-temperature resistance and wear resistance was realized, which contributed to the high-value utilization of nanocellulose.
34742435	3	41	theme	surface	453:459	arg1	roughness					461:469	the surface roughness	449:469	the surface roughness of nanocellulose	449:486	Polydopamine was produced by dopamine under alkaline conditions, creating an adhesive substance, which reinforced the hydrophobic long chains and increased the surface roughness of nanocellulose.
34742435	6	42	theme	electron	800:807	arg1	images					820:825	Scanning electron microscope images	791:825	Scanning electron microscope images	791:825	Scanning electron microscope images revealed that the modified nanocellulose had a smaller particle size and more uniform distribution, which effectively improved the hydrophobicity of the nanocellulose.
34742435	1	43	theme	non-toxic	149:157	arg1	system					187:192	a non-toxic octadecylamine/polydopamine system	147:192	a non-toxic octadecylamine/polydopamine system	147:192	We prepared super-hydrophobic nanocellulose films using a non-toxic octadecylamine/polydopamine system.
34742435	7	44	with	films	1043:1047	arg1	resistance					1071:1080	high-temperature resistance	1054:1080	high-temperature resistance	1054:1080	Thus, the green preparation of superhydrophobic films with high-temperature resistance and wear resistance was realized, which contributed to the high-value utilization of nanocellulose.
34742435	7	44	with	films	1043:1047	arg1	resistance					1091:1100	wear resistance	1086:1100	wear resistance	1086:1100	Thus, the green preparation of superhydrophobic films with high-temperature resistance and wear resistance was realized, which contributed to the high-value utilization of nanocellulose.
34742435	3	45	theme	alkaline	337:344	arg1	conditions					346:355	alkaline conditions	337:355	alkaline conditions	337:355	Polydopamine was produced by dopamine under alkaline conditions, creating an adhesive substance, which reinforced the hydrophobic long chains and increased the surface roughness of nanocellulose.
34742435	6	46	theme	Scanning	791:798	arg1	images					820:825	Scanning electron microscope images	791:825	Scanning electron microscope images	791:825	Scanning electron microscope images revealed that the modified nanocellulose had a smaller particle size and more uniform distribution, which effectively improved the hydrophobicity of the nanocellulose.
34742435	1	47	theme	octadecylamine/polydopamine	159:185	arg1	system					187:192	a non-toxic octadecylamine/polydopamine system	147:192	a non-toxic octadecylamine/polydopamine system	147:192	We prepared super-hydrophobic nanocellulose films using a non-toxic octadecylamine/polydopamine system.
34742435	5	48	dep	reached	775:781	arg1	reacting					695:702	reacting	695:702	reacting at 60 °C for 4 h	695:719	The results showed that with a 1:1 mass ratio of nanocellulose to octadecylamine, and reacting at 60 °C for 4 h, the contact angle of the obtained composite membrane reached 168.2°.
34742435	5	48	dep	reached	775:781	arg1	ratio					649:653	a 1:1 mass ratio	638:653	a 1:1 mass ratio of nanocellulose to octadecylamine	638:688	The results showed that with a 1:1 mass ratio of nanocellulose to octadecylamine, and reacting at 60 °C for 4 h, the contact angle of the obtained composite membrane reached 168.2°.
34742435	6	49	theme	particle	882:889	arg1	size					891:894	a smaller particle size	872:894	a smaller particle size	872:894	Scanning electron microscope images revealed that the modified nanocellulose had a smaller particle size and more uniform distribution, which effectively improved the hydrophobicity of the nanocellulose.
34742435	6	50	contain	had	868:870	arg2	distribution					913:924	more uniform distribution	900:924	more uniform distribution	900:924	Scanning electron microscope images revealed that the modified nanocellulose had a smaller particle size and more uniform distribution, which effectively improved the hydrophobicity of the nanocellulose.
34742435	6	50	contain	had	868:870	arg2	size					891:894	a smaller particle size	872:894	a smaller particle size	872:894	Scanning electron microscope images revealed that the modified nanocellulose had a smaller particle size and more uniform distribution, which effectively improved the hydrophobicity of the nanocellulose.
34742435	6	50	contain	had	868:870	arg1	nanocellulose					854:866	the modified nanocellulose	841:866	the modified nanocellulose	841:866	Scanning electron microscope images revealed that the modified nanocellulose had a smaller particle size and more uniform distribution, which effectively improved the hydrophobicity of the nanocellulose.
34742435	4	51	theme	time	562:565	arg1	effects					493:499	The effects	489:499	The effects of reagent concentration, reaction temperature, and reaction time on hydrophobicity	489:583	The effects of reagent concentration, reaction temperature, and reaction time on hydrophobicity were then investigated.
33197476	1	0	theme	seed	278:281	arg1	ash					283:285	flax seed ash	273:285	flax seed ash (FS)	273:290	In the present study, the adsorptive removal of methylene blue (MB) from wastewater was studied using the novel composite prepared by sodium alginate (SA) and flax seed ash (FS).
33197476	1	0	theme	seed	278:281	arg1	FS					288:289	FS	288:289	FS	288:289	In the present study, the adsorptive removal of methylene blue (MB) from wastewater was studied using the novel composite prepared by sodium alginate (SA) and flax seed ash (FS).
33197476	6	1	theme	composite	1174:1182	arg1	beads					1184:1188	SA-FS-2 composite beads	1166:1188	SA-FS-2 composite beads	1166:1188	The maximum adsorption capacity obtained from Langmuir model was found to be 333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C.
33197476	7	2	theme	order	1274:1278	arg1	model					1280:1284	pseudo-second order model	1260:1284	pseudo-second order model for SA, FS and SA-FS adsorbents	1260:1316	The adsorption kinetics were interpreted well by pseudo-second order model for SA, FS and SA-FS adsorbents.
33197476	2	3	theme	FS	398:399	arg1	FS					398:399	FS	398:399	FS	398:399	The adsorption of MB was carried out using the composite beads consisting of different weight amounts of FS at different pH values and temperatures using different dye concentrations.
33197476	2	3	theme	FS	398:399	arg1	amounts					387:393	different weight amounts	370:393	different weight amounts of FS	370:399	The adsorption of MB was carried out using the composite beads consisting of different weight amounts of FS at different pH values and temperatures using different dye concentrations.
33197476	5	4	theme	different	1030:1038	arg1	ratios					1043:1048	different FS ratios	1030:1048	different FS ratios	1030:1048	During the studies, it was determined that the adsorption percentage of MB reached the maximum with 90% at pH = 7 and 50 °C. Furthermore, Langmuir model fits well for the adsorption of MB using SA-FS with different FS ratios, SA, and FS adsorbents.
33197476	6	5	theme	SA-FS-2	1166:1172	arg1	beads					1184:1188	SA-FS-2 composite beads	1166:1188	SA-FS-2 composite beads	1166:1188	The maximum adsorption capacity obtained from Langmuir model was found to be 333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C.
33197476	5	6	with	SA	1051:1052	arg1	ratios					1043:1048	different FS ratios	1030:1048	different FS ratios	1030:1048	During the studies, it was determined that the adsorption percentage of MB reached the maximum with 90% at pH = 7 and 50 °C. Furthermore, Langmuir model fits well for the adsorption of MB using SA-FS with different FS ratios, SA, and FS adsorbents.
33197476	4	7	theme	surface	722:728	arg1	area					730:733	BJH surface area	718:733	BJH surface area	718:733	BET and BJH surface area values of SA-FS adsorbent beads were found to be 45.01 m2/g and 14.35 m2/g, respectively.
33197476	5	8	with	SA-FS	1019:1023	arg1	ratios					1043:1048	different FS ratios	1030:1048	different FS ratios	1030:1048	During the studies, it was determined that the adsorption percentage of MB reached the maximum with 90% at pH = 7 and 50 °C. Furthermore, Langmuir model fits well for the adsorption of MB using SA-FS with different FS ratios, SA, and FS adsorbents.
33197476	0	9	theme	kinetic	79:85	arg1	studies					105:111	kinetic and thermodynamic studies	79:111	kinetic and thermodynamic studies	79:111	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.
33197476	0	9	theme	kinetic	79:85	arg1	Isotherm					69:76	Isotherm	69:76	Isotherm	69:76	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.
33197476	0	10	from	Adsorption	0:9	arg1	beads					62:66	sodium alginate-flax seed ash beads	32:66	sodium alginate-flax seed ash beads	32:66	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.
33197476	4	11	theme	BET	710:712	arg1	values					735:740	BET and BJH surface area values	710:740	BET and BJH surface area values of SA-FS adsorbent beads	710:765	BET and BJH surface area values of SA-FS adsorbent beads were found to be 45.01 m2/g and 14.35 m2/g, respectively.
33197476	1	12	theme	novel	220:224	arg1	composite					226:234	the novel composite	216:234	the novel composite prepared by sodium alginate (SA) and flax seed ash (FS)	216:290	In the present study, the adsorptive removal of methylene blue (MB) from wastewater was studied using the novel composite prepared by sodium alginate (SA) and flax seed ash (FS).
33197476	6	13	theme	adsorption	1086:1095	arg1	capacity					1097:1104	The maximum adsorption capacity	1074:1104	The maximum adsorption capacity obtained from Langmuir model	1074:1133	The maximum adsorption capacity obtained from Langmuir model was found to be 333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C.
33197476	6	13	theme	adsorption	1086:1095	arg1	333.3 mg/g					1151:1160	333.3 mg/g	1151:1160	333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C	1151:1208	The maximum adsorption capacity obtained from Langmuir model was found to be 333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C.
33197476	5	14	theme	MB	897:898	arg1	percentage					883:892	the adsorption percentage	868:892	the adsorption percentage of MB	868:898	During the studies, it was determined that the adsorption percentage of MB reached the maximum with 90% at pH = 7 and 50 °C. Furthermore, Langmuir model fits well for the adsorption of MB using SA-FS with different FS ratios, SA, and FS adsorbents.
33197476	0	15	theme	thermodynamic	91:103	arg1	studies					105:111	kinetic and thermodynamic studies	79:111	kinetic and thermodynamic studies	79:111	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.
33197476	0	15	theme	thermodynamic	91:103	arg1	Isotherm					69:76	Isotherm	69:76	Isotherm	69:76	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.
33197476	4	16	theme	BJH	718:720	arg1	area					730:733	BJH surface area	718:733	BJH surface area	718:733	BET and BJH surface area values of SA-FS adsorbent beads were found to be 45.01 m2/g and 14.35 m2/g, respectively.
33197476	1	17	theme	adsorptive	140:149	arg1	removal					151:157	the adsorptive removal	136:157	the adsorptive removal of methylene blue (MB) from wastewater	136:196	In the present study, the adsorptive removal of methylene blue (MB) from wastewater was studied using the novel composite prepared by sodium alginate (SA) and flax seed ash (FS).
33197476	2	18	theme	different	370:378	arg1	FS					398:399	FS	398:399	FS	398:399	The adsorption of MB was carried out using the composite beads consisting of different weight amounts of FS at different pH values and temperatures using different dye concentrations.
33197476	2	18	theme	different	370:378	arg1	amounts					387:393	different weight amounts	370:393	different weight amounts of FS	370:399	The adsorption of MB was carried out using the composite beads consisting of different weight amounts of FS at different pH values and temperatures using different dye concentrations.
33197476	5	19	theme	MB	1010:1011	arg1	adsorption					996:1005	the adsorption	992:1005	the adsorption of MB using SA-FS with different FS ratios, SA, and FS adsorbents	992:1071	During the studies, it was determined that the adsorption percentage of MB reached the maximum with 90% at pH = 7 and 50 °C. Furthermore, Langmuir model fits well for the adsorption of MB using SA-FS with different FS ratios, SA, and FS adsorbents.
33197476	5	20	with	adsorbents	1062:1071	arg1	ratios					1043:1048	different FS ratios	1030:1048	different FS ratios	1030:1048	During the studies, it was determined that the adsorption percentage of MB reached the maximum with 90% at pH = 7 and 50 °C. Furthermore, Langmuir model fits well for the adsorption of MB using SA-FS with different FS ratios, SA, and FS adsorbents.
33197476	2	21	theme	MB	311:312	arg1	adsorption					297:306	The adsorption	293:306	The adsorption of MB	293:312	The adsorption of MB was carried out using the composite beads consisting of different weight amounts of FS at different pH values and temperatures using different dye concentrations.
33197476	6	22	theme	maximum	1078:1084	arg1	capacity					1097:1104	The maximum adsorption capacity	1074:1104	The maximum adsorption capacity obtained from Langmuir model	1074:1133	The maximum adsorption capacity obtained from Langmuir model was found to be 333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C.
33197476	6	22	theme	maximum	1078:1084	arg1	333.3 mg/g					1151:1160	333.3 mg/g	1151:1160	333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C	1151:1208	The maximum adsorption capacity obtained from Langmuir model was found to be 333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C.
33197476	8	23	theme	MB	1374:1375	arg1	adsorption					1377:1386	MB adsorption	1374:1386	MB adsorption by FS, SA, and SA-FS	1374:1407	The calculated thermodynamic parameters indicated that MB adsorption by FS, SA, and SA-FS were spontaneous and an endothermic.
33197476	1	24	theme	methylene	162:170	arg1	removal					151:157	the adsorptive removal	136:157	the adsorptive removal of methylene blue (MB) from wastewater	136:196	In the present study, the adsorptive removal of methylene blue (MB) from wastewater was studied using the novel composite prepared by sodium alginate (SA) and flax seed ash (FS).
33197476	0	25	theme	blue	24:27	arg1	methylene					14:22	methylene blue	14:27	methylene blue	14:27	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.
33197476	5	26	theme	FS	1059:1060	arg1	adsorbents					1062:1071	FS adsorbents	1059:1071	FS adsorbents	1059:1071	During the studies, it was determined that the adsorption percentage of MB reached the maximum with 90% at pH = 7 and 50 °C. Furthermore, Langmuir model fits well for the adsorption of MB using SA-FS with different FS ratios, SA, and FS adsorbents.
33197476	8	27	theme	thermodynamic	1334:1346	arg1	parameters					1348:1357	The calculated thermodynamic parameters	1319:1357	The calculated thermodynamic parameters	1319:1357	The calculated thermodynamic parameters indicated that MB adsorption by FS, SA, and SA-FS were spontaneous and an endothermic.
33197476	4	28	theme	beads	761:765	arg1	values					735:740	BET and BJH surface area values	710:740	BET and BJH surface area values of SA-FS adsorbent beads	710:765	BET and BJH surface area values of SA-FS adsorbent beads were found to be 45.01 m2/g and 14.35 m2/g, respectively.
33197476	5	29	theme	adsorption	872:881	arg1	percentage					883:892	the adsorption percentage	868:892	the adsorption percentage of MB	868:898	During the studies, it was determined that the adsorption percentage of MB reached the maximum with 90% at pH = 7 and 50 °C. Furthermore, Langmuir model fits well for the adsorption of MB using SA-FS with different FS ratios, SA, and FS adsorbents.
33197476	4	30	theme	adsorbent	751:759	arg1	beads					761:765	SA-FS adsorbent beads	745:765	SA-FS adsorbent beads	745:765	BET and BJH surface area values of SA-FS adsorbent beads were found to be 45.01 m2/g and 14.35 m2/g, respectively.
33197476	1	31	theme	blue	172:175	arg1	methylene					162:170	methylene blue	162:175	methylene blue (MB)	162:180	In the present study, the adsorptive removal of methylene blue (MB) from wastewater was studied using the novel composite prepared by sodium alginate (SA) and flax seed ash (FS).
33197476	1	31	theme	blue	172:175	arg1	MB					178:179	MB	178:179	MB	178:179	In the present study, the adsorptive removal of methylene blue (MB) from wastewater was studied using the novel composite prepared by sodium alginate (SA) and flax seed ash (FS).
33197476	0	32	theme	methylene	14:22	arg1	Adsorption					0:9	Adsorption	0:9	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.	0:112	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.
33197476	1	33	theme	sodium	248:253	arg1	SA					265:266	SA	265:266	SA	265:266	In the present study, the adsorptive removal of methylene blue (MB) from wastewater was studied using the novel composite prepared by sodium alginate (SA) and flax seed ash (FS).
33197476	1	33	theme	sodium	248:253	arg1	alginate					255:262	sodium alginate	248:262	sodium alginate (SA)	248:267	In the present study, the adsorptive removal of methylene blue (MB) from wastewater was studied using the novel composite prepared by sodium alginate (SA) and flax seed ash (FS).
33197476	8	34	theme	calculated	1323:1332	arg1	parameters					1348:1357	The calculated thermodynamic parameters	1319:1357	The calculated thermodynamic parameters	1319:1357	The calculated thermodynamic parameters indicated that MB adsorption by FS, SA, and SA-FS were spontaneous and an endothermic.
33197476	3	35	theme	characterization	481:496	arg1	studies					498:504	The characterization studies	477:504	The characterization studies of the composite beads	477:527	The characterization studies of the composite beads were performed using Fourier-Transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Brunauer-Emmett-Teller and Barrett-Joyner-Hallenda (BET-BJH) analyses.
33197476	0	36	theme	sodium	32:37	arg1	beads					62:66	sodium alginate-flax seed ash beads	32:66	sodium alginate-flax seed ash beads	32:66	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.
33197476	2	37	theme	dye	457:459	arg1	concentrations					461:474	different dye concentrations	447:474	different dye concentrations	447:474	The adsorption of MB was carried out using the composite beads consisting of different weight amounts of FS at different pH values and temperatures using different dye concentrations.
33197476	3	38	theme	beads	523:527	arg1	studies					498:504	The characterization studies	477:504	The characterization studies of the composite beads	477:527	The characterization studies of the composite beads were performed using Fourier-Transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Brunauer-Emmett-Teller and Barrett-Joyner-Hallenda (BET-BJH) analyses.
33197476	5	39	dep	pH = 7	932:937	arg1	fits					978:981	fits	978:981	fits well for the adsorption of MB using SA-FS with different FS ratios, SA, and FS adsorbents	978:1071	During the studies, it was determined that the adsorption percentage of MB reached the maximum with 90% at pH = 7 and 50 °C. Furthermore, Langmuir model fits well for the adsorption of MB using SA-FS with different FS ratios, SA, and FS adsorbents.
33197476	2	40	theme	different	447:455	arg1	concentrations					461:474	different dye concentrations	447:474	different dye concentrations	447:474	The adsorption of MB was carried out using the composite beads consisting of different weight amounts of FS at different pH values and temperatures using different dye concentrations.
33197476	4	41	theme	SA-FS	745:749	arg1	beads					761:765	SA-FS adsorbent beads	745:765	SA-FS adsorbent beads	745:765	BET and BJH surface area values of SA-FS adsorbent beads were found to be 45.01 m2/g and 14.35 m2/g, respectively.
33197476	7	42	theme	pseudo-second	1260:1272	arg1	model					1280:1284	pseudo-second order model	1260:1284	pseudo-second order model for SA, FS and SA-FS adsorbents	1260:1316	The adsorption kinetics were interpreted well by pseudo-second order model for SA, FS and SA-FS adsorbents.
33197476	2	43	theme	weight	380:385	arg1	FS					398:399	FS	398:399	FS	398:399	The adsorption of MB was carried out using the composite beads consisting of different weight amounts of FS at different pH values and temperatures using different dye concentrations.
33197476	2	43	theme	weight	380:385	arg1	amounts					387:393	different weight amounts	370:393	different weight amounts of FS	370:399	The adsorption of MB was carried out using the composite beads consisting of different weight amounts of FS at different pH values and temperatures using different dye concentrations.
33197476	0	44	theme	ash	58:60	arg1	beads					62:66	sodium alginate-flax seed ash beads	32:66	sodium alginate-flax seed ash beads	32:66	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.
33197476	0	45	theme	alginate-flax	39:51	arg1	beads					62:66	sodium alginate-flax seed ash beads	32:66	sodium alginate-flax seed ash beads	32:66	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.
33197476	3	46	theme	electron	608:615	arg1	SEM					629:631	SEM	629:631	SEM	629:631	The characterization studies of the composite beads were performed using Fourier-Transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Brunauer-Emmett-Teller and Barrett-Joyner-Hallenda (BET-BJH) analyses.
33197476	3	46	theme	electron	608:615	arg1	microscope					617:626	scanning electron microscope	599:626	scanning electron microscope (SEM)	599:632	The characterization studies of the composite beads were performed using Fourier-Transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Brunauer-Emmett-Teller and Barrett-Joyner-Hallenda (BET-BJH) analyses.
33197476	3	47	theme	composite	513:521	arg1	beads					523:527	the composite beads	509:527	the composite beads	509:527	The characterization studies of the composite beads were performed using Fourier-Transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Brunauer-Emmett-Teller and Barrett-Joyner-Hallenda (BET-BJH) analyses.
33197476	6	48	from	pH = 7	1193:1198	arg1	capacity					1097:1104	The maximum adsorption capacity	1074:1104	The maximum adsorption capacity obtained from Langmuir model	1074:1133	The maximum adsorption capacity obtained from Langmuir model was found to be 333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C.
33197476	6	48	from	pH = 7	1193:1198	arg1	333.3 mg/g					1151:1160	333.3 mg/g	1151:1160	333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C	1151:1208	The maximum adsorption capacity obtained from Langmuir model was found to be 333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C.
33197476	4	49	theme	area	730:733	arg1	values					735:740	BET and BJH surface area values	710:740	BET and BJH surface area values of SA-FS adsorbent beads	710:765	BET and BJH surface area values of SA-FS adsorbent beads were found to be 45.01 m2/g and 14.35 m2/g, respectively.
33197476	3	50	theme	Fourier-Transform	550:566	arg1	FT-IR					591:595	FT-IR	591:595	FT-IR	591:595	The characterization studies of the composite beads were performed using Fourier-Transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Brunauer-Emmett-Teller and Barrett-Joyner-Hallenda (BET-BJH) analyses.
33197476	3	50	theme	Fourier-Transform	550:566	arg1	spectroscopy					577:588	Fourier-Transform infrared spectroscopy	550:588	Fourier-Transform infrared spectroscopy (FT-IR)	550:596	The characterization studies of the composite beads were performed using Fourier-Transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Brunauer-Emmett-Teller and Barrett-Joyner-Hallenda (BET-BJH) analyses.
33197476	6	51	theme	Langmuir	1120:1127	arg1	model					1129:1133	Langmuir model	1120:1133	Langmuir model	1120:1133	The maximum adsorption capacity obtained from Langmuir model was found to be 333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C.
33197476	3	52	dep	spectroscopy	577:588	arg1	analyses					700:707	analyses	700:707	analyses	700:707	The characterization studies of the composite beads were performed using Fourier-Transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Brunauer-Emmett-Teller and Barrett-Joyner-Hallenda (BET-BJH) analyses.
33197476	1	53	from	wastewater	187:196	arg1	removal					151:157	the adsorptive removal	136:157	the adsorptive removal of methylene blue (MB) from wastewater	136:196	In the present study, the adsorptive removal of methylene blue (MB) from wastewater was studied using the novel composite prepared by sodium alginate (SA) and flax seed ash (FS).
33197476	5	54	theme	Langmuir	963:970	arg1	model					972:976	Langmuir model	963:976	Langmuir model	963:976	During the studies, it was determined that the adsorption percentage of MB reached the maximum with 90% at pH = 7 and 50 °C. Furthermore, Langmuir model fits well for the adsorption of MB using SA-FS with different FS ratios, SA, and FS adsorbents.
33197476	3	55	theme	infrared	568:575	arg1	FT-IR					591:595	FT-IR	591:595	FT-IR	591:595	The characterization studies of the composite beads were performed using Fourier-Transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Brunauer-Emmett-Teller and Barrett-Joyner-Hallenda (BET-BJH) analyses.
33197476	3	55	theme	infrared	568:575	arg1	spectroscopy					577:588	Fourier-Transform infrared spectroscopy	550:588	Fourier-Transform infrared spectroscopy (FT-IR)	550:596	The characterization studies of the composite beads were performed using Fourier-Transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Brunauer-Emmett-Teller and Barrett-Joyner-Hallenda (BET-BJH) analyses.
33197476	2	56	theme	different	404:412	arg1	values					417:422	different pH values	404:422	different pH values	404:422	The adsorption of MB was carried out using the composite beads consisting of different weight amounts of FS at different pH values and temperatures using different dye concentrations.
33197476	6	57	from	50 °C	1204:1208	arg1	capacity					1097:1104	The maximum adsorption capacity	1074:1104	The maximum adsorption capacity obtained from Langmuir model	1074:1133	The maximum adsorption capacity obtained from Langmuir model was found to be 333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C.
33197476	6	57	from	50 °C	1204:1208	arg1	333.3 mg/g					1151:1160	333.3 mg/g	1151:1160	333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C	1151:1208	The maximum adsorption capacity obtained from Langmuir model was found to be 333.3 mg/g for SA-FS-2 composite beads at pH = 7 and 50 °C.
33197476	2	58	theme	pH	414:415	arg1	values					417:422	different pH values	404:422	different pH values	404:422	The adsorption of MB was carried out using the composite beads consisting of different weight amounts of FS at different pH values and temperatures using different dye concentrations.
33197476	3	59	theme	scanning	599:606	arg1	SEM					629:631	SEM	629:631	SEM	629:631	The characterization studies of the composite beads were performed using Fourier-Transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Brunauer-Emmett-Teller and Barrett-Joyner-Hallenda (BET-BJH) analyses.
33197476	3	59	theme	scanning	599:606	arg1	microscope					617:626	scanning electron microscope	599:626	scanning electron microscope (SEM)	599:632	The characterization studies of the composite beads were performed using Fourier-Transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Brunauer-Emmett-Teller and Barrett-Joyner-Hallenda (BET-BJH) analyses.
33197476	5	60	theme	FS	1040:1041	arg1	ratios					1043:1048	different FS ratios	1030:1048	different FS ratios	1030:1048	During the studies, it was determined that the adsorption percentage of MB reached the maximum with 90% at pH = 7 and 50 °C. Furthermore, Langmuir model fits well for the adsorption of MB using SA-FS with different FS ratios, SA, and FS adsorbents.
33197476	2	61	theme	composite	340:348	arg1	beads					350:354	the composite beads	336:354	the composite beads consisting of different weight amounts of FS	336:399	The adsorption of MB was carried out using the composite beads consisting of different weight amounts of FS at different pH values and temperatures using different dye concentrations.
33197476	1	62	theme	present	121:127	arg1	study					129:133	the present study	117:133	the present study	117:133	In the present study, the adsorptive removal of methylene blue (MB) from wastewater was studied using the novel composite prepared by sodium alginate (SA) and flax seed ash (FS).
33197476	7	63	theme	adsorption	1215:1224	arg1	kinetics					1226:1233	The adsorption kinetics	1211:1233	The adsorption kinetics	1211:1233	The adsorption kinetics were interpreted well by pseudo-second order model for SA, FS and SA-FS adsorbents.
33197476	0	64	theme	seed	53:56	arg1	beads					62:66	sodium alginate-flax seed ash beads	32:66	sodium alginate-flax seed ash beads	32:66	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.
33197476	1	65	theme	flax	273:276	arg1	ash					283:285	flax seed ash	273:285	flax seed ash (FS)	273:290	In the present study, the adsorptive removal of methylene blue (MB) from wastewater was studied using the novel composite prepared by sodium alginate (SA) and flax seed ash (FS).
33197476	1	65	theme	flax	273:276	arg1	FS					288:289	FS	288:289	FS	288:289	In the present study, the adsorptive removal of methylene blue (MB) from wastewater was studied using the novel composite prepared by sodium alginate (SA) and flax seed ash (FS).
33197476	0	66	dep	Adsorption	0:9	arg1	studies					105:111	kinetic and thermodynamic studies	79:111	kinetic and thermodynamic studies	79:111	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.
33197476	0	66	dep	Adsorption	0:9	arg1	Isotherm					69:76	Isotherm	69:76	Isotherm	69:76	Adsorption of methylene blue on sodium alginate-flax seed ash beads: Isotherm, kinetic and thermodynamic studies.
33197476	7	67	dep	SA	1290:1291	arg1	adsorbents					1307:1316	adsorbents	1307:1316	adsorbents	1307:1316	The adsorption kinetics were interpreted well by pseudo-second order model for SA, FS and SA-FS adsorbents.
33316847	5	0	theme	12 h.	750:754	arg1	surgery					761:767	12 h. Sham surgery	750:767	12 h. Sham surgery	750:767	Limbs were replanted and observed for 12 h. Sham surgery was performed on contralateral forelimbs (n = 12).
33316847	6	1	theme	more	917:920	arg1	damage					922:927	more damage	917:927	higher score equals more damage	897:927	Histology analysis scored four subgroups representing different alterations (higher score equals more damage).
33316847	3	2	theme	muscle	518:523	arg1	damage					525:530	muscle damage	518:530	muscle damage	518:530	This article assessed neuromuscular function and compared results to histological alterations to predict muscle damage after ECP.
33316847	1	3	theme	irreversible	235:246	arg1	damage					255:260	irreversible muscle damage	235:260	irreversible muscle damage	235:260	The current standard for composite tissue preservation is static cold storage (SCS) and is limited to 6 h until irreversible muscle damage occurs.
33316847	5	4	theme	Sham	756:759	arg1	surgery					761:767	12 h. Sham surgery	750:767	12 h. Sham surgery	750:767	Limbs were replanted and observed for 12 h. Sham surgery was performed on contralateral forelimbs (n = 12).
33316847	7	5	theme	nerve	963:967	arg1	stimulation					969:979	median nerve stimulation	956:979	median nerve stimulation	956:979	Muscle contraction after median nerve stimulation was comparable between ECP, SCS, and sham limbs (P = 0.193).
33316847	4	6	theme	Wisconsin	684:692	arg1	n = 6					704:708	n = 6	704:708	n = 6	704:708	Forelimbs of twelve Dutch landrace pigs were amputated and preserved by 4 h SCS at 4-6 °C (n = 6) or 18 h mid-thermic ECP with University of Wisconsin solution (n = 6).
33316847	4	6	theme	Wisconsin	684:692	arg1	solution					694:701	Wisconsin solution	684:701	Wisconsin solution (n = 6)	684:709	Forelimbs of twelve Dutch landrace pigs were amputated and preserved by 4 h SCS at 4-6 °C (n = 6) or 18 h mid-thermic ECP with University of Wisconsin solution (n = 6).
33316847	10	7	theme	muscle	1193:1198	arg1	contraction					1200:1210	In-vivo muscle contraction	1185:1210	In-vivo muscle contraction	1185:1210	In-vivo muscle contraction was well preserved after 18 h ECP compared to short SCS, although histology seemed inferior in this group.
33316847	1	8	theme	muscle	248:253	arg1	damage					255:260	irreversible muscle damage	235:260	irreversible muscle damage	235:260	The current standard for composite tissue preservation is static cold storage (SCS) and is limited to 6 h until irreversible muscle damage occurs.
33316847	0	9	theme	nerve	104:108	arg1	stimulation					110:120	nerve stimulation	104:120	nerve stimulation	104:120	Successful 18-h acellular extracorporeal perfusion and replantation of porcine limbs - Histology versus nerve stimulation.
33316847	6	10	theme	score	904:908	arg1	equals					910:915	higher score equals	897:915	higher score equals more damage	897:927	Histology analysis scored four subgroups representing different alterations (higher score equals more damage).
33316847	4	11	theme	mid-thermic	649:659	arg1	ECP					661:663	18 h mid-thermic ECP	644:663	18 h mid-thermic ECP	644:663	Forelimbs of twelve Dutch landrace pigs were amputated and preserved by 4 h SCS at 4-6 °C (n = 6) or 18 h mid-thermic ECP with University of Wisconsin solution (n = 6).
33316847	6	12	theme	higher	897:902	arg1	equals					910:915	higher score equals	897:915	higher score equals more damage	897:927	Histology analysis scored four subgroups representing different alterations (higher score equals more damage).
33316847	10	13	theme	18 h	1237:1240	arg1	ECP					1242:1244	18 h ECP	1237:1244	18 h ECP	1237:1244	In-vivo muscle contraction was well preserved after 18 h ECP compared to short SCS, although histology seemed inferior in this group.
33316847	10	14	from	group	1312:1316	arg1	inferior					1295:1302	inferior	1295:1302	inferior	1295:1302	In-vivo muscle contraction was well preserved after 18 h ECP compared to short SCS, although histology seemed inferior in this group.
33316847	11	15	theme	muscle	1362:1367	arg1	function					1369:1376	muscle function	1362:1376	muscle function	1362:1376	Histology, therefore, did not correlate to muscle function at 12 h after replantation.
33316847	5	16	theme	contralateral	786:798	arg1	forelimbs					800:808	contralateral forelimbs	786:808	contralateral forelimbs (n = 12)	786:817	Limbs were replanted and observed for 12 h. Sham surgery was performed on contralateral forelimbs (n = 12).
33316847	5	16	theme	contralateral	786:798	arg1	n = 12					811:816	n = 12	811:816	n = 12	811:816	Limbs were replanted and observed for 12 h. Sham surgery was performed on contralateral forelimbs (n = 12).
33316847	2	17	theme	Extracorporeal	270:283	arg1	perfusion					285:293	Extracorporeal perfusion	270:293	Extracorporeal perfusion (ECP)	270:299	Extracorporeal perfusion (ECP) is a promising technique for prolonged preservation, however, functional results have been scarcely researched.
33316847	2	17	theme	Extracorporeal	270:283	arg1	technique					316:324	a promising technique	304:324	a promising technique for prolonged preservation	304:351	Extracorporeal perfusion (ECP) is a promising technique for prolonged preservation, however, functional results have been scarcely researched.
33316847	2	17	theme	Extracorporeal	270:283	arg1	ECP					296:298	ECP	296:298	ECP	296:298	Extracorporeal perfusion (ECP) is a promising technique for prolonged preservation, however, functional results have been scarcely researched.
33316847	4	18	from	ECP	661:663	arg1	SCS					619:621	4 h SCS	615:621	4 h SCS at 4-6 °C (n = 6) or 18 h mid-thermic ECP	615:663	Forelimbs of twelve Dutch landrace pigs were amputated and preserved by 4 h SCS at 4-6 °C (n = 6) or 18 h mid-thermic ECP with University of Wisconsin solution (n = 6).
33316847	1	19	theme	static	181:186	arg1	storage					193:199	static cold storage	181:199	static cold storage (SCS)	181:205	The current standard for composite tissue preservation is static cold storage (SCS) and is limited to 6 h until irreversible muscle damage occurs.
33316847	1	19	theme	static	181:186	arg1	standard					135:142	standard	135:142	standard	135:142	The current standard for composite tissue preservation is static cold storage (SCS) and is limited to 6 h until irreversible muscle damage occurs.
33316847	1	19	theme	static	181:186	arg1	SCS					202:204	SCS	202:204	SCS	202:204	The current standard for composite tissue preservation is static cold storage (SCS) and is limited to 6 h until irreversible muscle damage occurs.
33316847	6	20	dep	equals	910:915	arg1	damage					922:927	more damage	917:927	higher score equals more damage	897:927	Histology analysis scored four subgroups representing different alterations (higher score equals more damage).
33316847	7	21	theme	Muscle	931:936	arg1	contraction					938:948	Muscle contraction	931:948	Muscle contraction after median nerve stimulation	931:979	Muscle contraction after median nerve stimulation was comparable between ECP, SCS, and sham limbs (P = 0.193).
33316847	1	22	theme	cold	188:191	arg1	storage					193:199	static cold storage	181:199	static cold storage (SCS)	181:205	The current standard for composite tissue preservation is static cold storage (SCS) and is limited to 6 h until irreversible muscle damage occurs.
33316847	1	22	theme	cold	188:191	arg1	standard					135:142	standard	135:142	standard	135:142	The current standard for composite tissue preservation is static cold storage (SCS) and is limited to 6 h until irreversible muscle damage occurs.
33316847	1	22	theme	cold	188:191	arg1	SCS					202:204	SCS	202:204	SCS	202:204	The current standard for composite tissue preservation is static cold storage (SCS) and is limited to 6 h until irreversible muscle damage occurs.
33316847	0	23	theme	18-h	11:14	arg1	perfusion					41:49	Successful 18-h acellular extracorporeal perfusion	0:49	Successful 18-h acellular extracorporeal perfusion	0:49	Successful 18-h acellular extracorporeal perfusion and replantation of porcine limbs - Histology versus nerve stimulation.
33316847	6	24	theme	different	874:882	arg1	alterations					884:894	different alterations	874:894	different alterations (higher score equals more damage)	874:928	Histology analysis scored four subgroups representing different alterations (higher score equals more damage).
33316847	4	25	from	4-6 °C	626:631	arg1	SCS					619:621	4 h SCS	615:621	4 h SCS at 4-6 °C (n = 6) or 18 h mid-thermic ECP	615:663	Forelimbs of twelve Dutch landrace pigs were amputated and preserved by 4 h SCS at 4-6 °C (n = 6) or 18 h mid-thermic ECP with University of Wisconsin solution (n = 6).
33316847	0	26	theme	Successful	0:9	arg1	perfusion					41:49	Successful 18-h acellular extracorporeal perfusion	0:49	Successful 18-h acellular extracorporeal perfusion	0:49	Successful 18-h acellular extracorporeal perfusion and replantation of porcine limbs - Histology versus nerve stimulation.
33316847	4	27	theme	landrace	569:576	arg1	pigs					578:581	twelve Dutch landrace pigs	556:581	twelve Dutch landrace pigs	556:581	Forelimbs of twelve Dutch landrace pigs were amputated and preserved by 4 h SCS at 4-6 °C (n = 6) or 18 h mid-thermic ECP with University of Wisconsin solution (n = 6).
33316847	8	28	theme	Histology	1042:1050	arg1	scores					1052:1057	Histology scores	1042:1057	Histology scores	1042:1057	Histology scores were higher in ECP limbs compared to SCS limbs (4.8 vs. 1.5, P = 0.013).
33316847	9	29	theme	more	1157:1160	arg1	oedema					1162:1167	more oedema	1157:1167	more oedema in these limbs	1157:1182	This was mainly based on more oedema in these limbs.
33316847	10	30	theme	short	1258:1262	arg1	SCS					1264:1266	short SCS	1258:1266	short SCS	1258:1266	In-vivo muscle contraction was well preserved after 18 h ECP compared to short SCS, although histology seemed inferior in this group.
33316847	2	31	theme	functional	363:372	arg1	results					374:380	functional results	363:380	functional results	363:380	Extracorporeal perfusion (ECP) is a promising technique for prolonged preservation, however, functional results have been scarcely researched.
33316847	0	32	theme	extracorporeal	26:39	arg1	perfusion					41:49	Successful 18-h acellular extracorporeal perfusion	0:49	Successful 18-h acellular extracorporeal perfusion	0:49	Successful 18-h acellular extracorporeal perfusion and replantation of porcine limbs - Histology versus nerve stimulation.
33316847	4	33	theme	Dutch	563:567	arg1	pigs					578:581	twelve Dutch landrace pigs	556:581	twelve Dutch landrace pigs	556:581	Forelimbs of twelve Dutch landrace pigs were amputated and preserved by 4 h SCS at 4-6 °C (n = 6) or 18 h mid-thermic ECP with University of Wisconsin solution (n = 6).
33316847	7	34	theme	median	956:961	arg1	stimulation					969:979	median nerve stimulation	956:979	median nerve stimulation	956:979	Muscle contraction after median nerve stimulation was comparable between ECP, SCS, and sham limbs (P = 0.193).
33316847	12	35	theme	best	1484:1487	arg1	function					1468:1475	neuromuscular function	1454:1475	neuromuscular function	1454:1475	This leads to the question whether histology or neuromuscular function is the best predictor for transplant success.
33316847	12	35	theme	best	1484:1487	arg1	predictor					1489:1497	the best predictor	1480:1497	the best predictor for transplant success	1480:1520	This leads to the question whether histology or neuromuscular function is the best predictor for transplant success.
33316847	12	35	theme	best	1484:1487	arg1	histology					1441:1449	histology	1441:1449	histology	1441:1449	This leads to the question whether histology or neuromuscular function is the best predictor for transplant success.
33316847	10	36	from	inferior	1295:1302	arg1	group					1312:1316	this group	1307:1316	this group	1307:1316	In-vivo muscle contraction was well preserved after 18 h ECP compared to short SCS, although histology seemed inferior in this group.
33316847	0	37	theme	acellular	16:24	arg1	perfusion					41:49	Successful 18-h acellular extracorporeal perfusion	0:49	Successful 18-h acellular extracorporeal perfusion	0:49	Successful 18-h acellular extracorporeal perfusion and replantation of porcine limbs - Histology versus nerve stimulation.
33316847	12	38	theme	neuromuscular	1454:1466	arg1	function					1468:1475	neuromuscular function	1454:1475	neuromuscular function	1454:1475	This leads to the question whether histology or neuromuscular function is the best predictor for transplant success.
33316847	12	38	theme	neuromuscular	1454:1466	arg1	predictor					1489:1497	the best predictor	1480:1497	the best predictor for transplant success	1480:1520	This leads to the question whether histology or neuromuscular function is the best predictor for transplant success.
33316847	12	38	theme	neuromuscular	1454:1466	arg1	histology					1441:1449	histology	1441:1449	histology	1441:1449	This leads to the question whether histology or neuromuscular function is the best predictor for transplant success.
33316847	4	39	theme	pigs	578:581	arg1	Forelimbs					543:551	Forelimbs	543:551	Forelimbs of twelve Dutch landrace pigs	543:581	Forelimbs of twelve Dutch landrace pigs were amputated and preserved by 4 h SCS at 4-6 °C (n = 6) or 18 h mid-thermic ECP with University of Wisconsin solution (n = 6).
33316847	8	40	theme	ECP	1074:1076	arg1	limbs					1078:1082	ECP limbs	1074:1082	ECP limbs	1074:1082	Histology scores were higher in ECP limbs compared to SCS limbs (4.8 vs. 1.5, P = 0.013).
33316847	3	41	theme	neuromuscular	435:447	arg1	function					449:456	neuromuscular function	435:456	neuromuscular function	435:456	This article assessed neuromuscular function and compared results to histological alterations to predict muscle damage after ECP.
33316847	8	42	dep	limbs	1100:1104	arg1	4.8					1107:1109	4.8	1107:1109	4.8	1107:1109	Histology scores were higher in ECP limbs compared to SCS limbs (4.8 vs. 1.5, P = 0.013).
33316847	8	42	dep	limbs	1100:1104	arg1	P = 0.013					1120:1128	P = 0.013	1120:1128	P = 0.013	1120:1128	Histology scores were higher in ECP limbs compared to SCS limbs (4.8 vs. 1.5, P = 0.013).
33316847	12	43	theme	transplant	1503:1512	arg1	success					1514:1520	transplant success	1503:1520	transplant success	1503:1520	This leads to the question whether histology or neuromuscular function is the best predictor for transplant success.
33316847	8	44	theme	SCS	1096:1098	arg1	limbs					1100:1104	SCS limbs	1096:1104	SCS limbs (4.8 vs. 1.5, P = 0.013)	1096:1129	Histology scores were higher in ECP limbs compared to SCS limbs (4.8 vs. 1.5, P = 0.013).
33316847	2	45	theme	prolonged	330:338	arg1	preservation					340:351	prolonged preservation	330:351	prolonged preservation	330:351	Extracorporeal perfusion (ECP) is a promising technique for prolonged preservation, however, functional results have been scarcely researched.
33316847	0	46	dep	perfusion	41:49	arg1	Histology					87:95	Histology	87:95	Histology	87:95	Successful 18-h acellular extracorporeal perfusion and replantation of porcine limbs - Histology versus nerve stimulation.
33316847	0	46	dep	perfusion	41:49	arg1	stimulation					110:120	nerve stimulation	104:120	nerve stimulation	104:120	Successful 18-h acellular extracorporeal perfusion and replantation of porcine limbs - Histology versus nerve stimulation.
33316847	9	47	from	oedema	1162:1167	arg1	limbs					1178:1182	these limbs	1172:1182	these limbs	1172:1182	This was mainly based on more oedema in these limbs.
33316847	7	48	theme	sham	1018:1021	arg1	P = 0.193					1030:1038	P = 0.193	1030:1038	P = 0.193	1030:1038	Muscle contraction after median nerve stimulation was comparable between ECP, SCS, and sham limbs (P = 0.193).
33316847	7	48	theme	sham	1018:1021	arg1	limbs					1023:1027	ECP, SCS, and sham limbs	1004:1027	ECP, SCS, and sham limbs (P = 0.193)	1004:1039	Muscle contraction after median nerve stimulation was comparable between ECP, SCS, and sham limbs (P = 0.193).
33316847	6	49	theme	Histology	820:828	arg1	analysis					830:837	Histology analysis	820:837	Histology analysis	820:837	Histology analysis scored four subgroups representing different alterations (higher score equals more damage).
33316847	7	50	theme	SCS	1009:1011	arg1	P = 0.193					1030:1038	P = 0.193	1030:1038	P = 0.193	1030:1038	Muscle contraction after median nerve stimulation was comparable between ECP, SCS, and sham limbs (P = 0.193).
33316847	7	50	theme	SCS	1009:1011	arg1	limbs					1023:1027	ECP, SCS, and sham limbs	1004:1027	ECP, SCS, and sham limbs (P = 0.193)	1004:1039	Muscle contraction after median nerve stimulation was comparable between ECP, SCS, and sham limbs (P = 0.193).
33316847	3	51	theme	histological	482:493	arg1	alterations					495:505	histological alterations to predict muscle damage after ECP	482:540	histological alterations to predict muscle damage after ECP	482:540	This article assessed neuromuscular function and compared results to histological alterations to predict muscle damage after ECP.
33316847	6	52	dep	alterations	884:894	arg1	equals					910:915	higher score equals	897:915	higher score equals more damage	897:927	Histology analysis scored four subgroups representing different alterations (higher score equals more damage).
33316847	2	53	theme	promising	306:314	arg1	perfusion					285:293	Extracorporeal perfusion	270:293	Extracorporeal perfusion (ECP)	270:299	Extracorporeal perfusion (ECP) is a promising technique for prolonged preservation, however, functional results have been scarcely researched.
33316847	2	53	theme	promising	306:314	arg1	technique					316:324	a promising technique	304:324	a promising technique for prolonged preservation	304:351	Extracorporeal perfusion (ECP) is a promising technique for prolonged preservation, however, functional results have been scarcely researched.
33316847	4	54	theme	4 h	615:617	arg1	SCS					619:621	4 h SCS	615:621	4 h SCS at 4-6 °C (n = 6) or 18 h mid-thermic ECP	615:663	Forelimbs of twelve Dutch landrace pigs were amputated and preserved by 4 h SCS at 4-6 °C (n = 6) or 18 h mid-thermic ECP with University of Wisconsin solution (n = 6).
33316847	0	55	theme	limbs	79:83	arg1	replantation					55:66	replantation	55:66	replantation	55:66	Successful 18-h acellular extracorporeal perfusion and replantation of porcine limbs - Histology versus nerve stimulation.
33316847	0	55	theme	limbs	79:83	arg1	perfusion					41:49	Successful 18-h acellular extracorporeal perfusion	0:49	Successful 18-h acellular extracorporeal perfusion	0:49	Successful 18-h acellular extracorporeal perfusion and replantation of porcine limbs - Histology versus nerve stimulation.
33316847	10	56	theme	In-vivo	1185:1191	arg1	contraction					1200:1210	In-vivo muscle contraction	1185:1210	In-vivo muscle contraction	1185:1210	In-vivo muscle contraction was well preserved after 18 h ECP compared to short SCS, although histology seemed inferior in this group.
33316847	7	57	theme	ECP	1004:1006	arg1	P = 0.193					1030:1038	P = 0.193	1030:1038	P = 0.193	1030:1038	Muscle contraction after median nerve stimulation was comparable between ECP, SCS, and sham limbs (P = 0.193).
33316847	7	57	theme	ECP	1004:1006	arg1	limbs					1023:1027	ECP, SCS, and sham limbs	1004:1027	ECP, SCS, and sham limbs (P = 0.193)	1004:1039	Muscle contraction after median nerve stimulation was comparable between ECP, SCS, and sham limbs (P = 0.193).
33316847	1	58	theme	composite	148:156	arg1	preservation					165:176	composite tissue preservation	148:176	composite tissue preservation	148:176	The current standard for composite tissue preservation is static cold storage (SCS) and is limited to 6 h until irreversible muscle damage occurs.
33316847	4	59	theme	18 h	644:647	arg1	ECP					661:663	18 h mid-thermic ECP	644:663	18 h mid-thermic ECP	644:663	Forelimbs of twelve Dutch landrace pigs were amputated and preserved by 4 h SCS at 4-6 °C (n = 6) or 18 h mid-thermic ECP with University of Wisconsin solution (n = 6).
33316847	0	60	theme	porcine	71:77	arg1	limbs					79:83	porcine limbs	71:83	porcine limbs	71:83	Successful 18-h acellular extracorporeal perfusion and replantation of porcine limbs - Histology versus nerve stimulation.
33316847	1	61	theme	tissue	158:163	arg1	preservation					165:176	composite tissue preservation	148:176	composite tissue preservation	148:176	The current standard for composite tissue preservation is static cold storage (SCS) and is limited to 6 h until irreversible muscle damage occurs.
34420720	4	0	theme	Pickering	448:456	arg1	emulsion					458:465	Pickering emulsion	448:465	Pickering emulsion	448:465	Cellulose nanofibrils (CNFs) were used to stabilize PCM into Pickering emulsion, which was further integrated into a 3D interconnected CNF network forming CNF/PCM composite aerogel.
34420720	4	1	theme	composite	550:558	arg1	aerogel					560:566	CNF/PCM composite aerogel	542:566	CNF/PCM composite aerogel	542:566	Cellulose nanofibrils (CNFs) were used to stabilize PCM into Pickering emulsion, which was further integrated into a 3D interconnected CNF network forming CNF/PCM composite aerogel.
34420720	3	2	theme	strong	289:294	arg1	aerogel					317:323	a lightweight, strong, and form-stable PCM aerogel	274:323	a lightweight, strong, and form-stable PCM aerogel	274:323	Herein, a lightweight, strong, and form-stable PCM aerogel was fabricated using Pickering emulsion templating technique.
34420720	4	3	theme	CNF/PCM	542:548	arg1	aerogel					560:566	CNF/PCM composite aerogel	542:566	CNF/PCM composite aerogel	542:566	Cellulose nanofibrils (CNFs) were used to stabilize PCM into Pickering emulsion, which was further integrated into a 3D interconnected CNF network forming CNF/PCM composite aerogel.
34420720	0	4	theme	latent	90:95	arg1	heat					97:100	high latent heat	85:100	high latent heat	85:100	Lightweight, strong, and form-stable cellulose nanofibrils phase change aerogel with high latent heat.
34420720	6	5	theme	paraffin	857:864	arg1	173.59 J·g-1					816:827	173.59 J·g-1	816:827	173.59 J·g-1	816:827	The latent heat of CNF/PCM composite aerogel could reach 173.59 J·g-1, approximately 84.4% of the paraffin.
34420720	6	5	theme	paraffin	857:864	arg1	%					848:848	approximately 84.4%	830:848	approximately 84.4% of the paraffin	830:864	The latent heat of CNF/PCM composite aerogel could reach 173.59 J·g-1, approximately 84.4% of the paraffin.
34420720	6	5	theme	paraffin	857:864	arg1	paraffin					857:864	the paraffin	853:864	the paraffin	853:864	The latent heat of CNF/PCM composite aerogel could reach 173.59 J·g-1, approximately 84.4% of the paraffin.
34420720	8	6	theme	CNF/PCM	1036:1042	arg1	aerogel					1054:1060	the CNF/PCM composite aerogel	1032:1060	the CNF/PCM composite aerogel	1032:1060	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
34420720	0	7	with	aerogel	72:78	arg1	heat					97:100	high latent heat	85:100	high latent heat	85:100	Lightweight, strong, and form-stable cellulose nanofibrils phase change aerogel with high latent heat.
34420720	0	8	theme	high	85:88	arg1	heat					97:100	high latent heat	85:100	high latent heat	85:100	Lightweight, strong, and form-stable cellulose nanofibrils phase change aerogel with high latent heat.
34420720	4	9	theme	Cellulose	387:395	arg1	CNFs					410:413	CNFs	410:413	CNFs	410:413	Cellulose nanofibrils (CNFs) were used to stabilize PCM into Pickering emulsion, which was further integrated into a 3D interconnected CNF network forming CNF/PCM composite aerogel.
34420720	4	9	theme	Cellulose	387:395	arg1	nanofibrils					397:407	Cellulose nanofibrils	387:407	Cellulose nanofibrils (CNFs)	387:414	Cellulose nanofibrils (CNFs) were used to stabilize PCM into Pickering emulsion, which was further integrated into a 3D interconnected CNF network forming CNF/PCM composite aerogel.
34420720	8	10	from	applications	1093:1104	arg1	building					1130:1137	smart textile, smart building	1109:1137	smart textile, smart building	1109:1137	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
34420720	8	10	from	applications	1093:1104	arg1	devices					1166:1172	electronic devices	1155:1172	electronic devices	1155:1172	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
34420720	8	10	from	applications	1093:1104	arg1	batteries					1140:1148	batteries	1140:1148	batteries	1140:1148	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
34420720	3	11	theme	form-stable	301:311	arg1	aerogel					317:323	a lightweight, strong, and form-stable PCM aerogel	274:323	a lightweight, strong, and form-stable PCM aerogel	274:323	Herein, a lightweight, strong, and form-stable PCM aerogel was fabricated using Pickering emulsion templating technique.
34420720	8	12	theme	aerogel	1054:1060	arg1	properties					1018:1027	The sustainability and impressive thermal regulating properties	965:1027	properties	1018:1027	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
34420720	8	12	theme	aerogel	1054:1060	arg1	sustainability					969:982	The sustainability and impressive thermal regulating properties	965:1027	sustainability	969:982	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
34420720	7	13	theme	thermal	919:925	arg1	conductivity					927:938	relatively low thermal conductivity	904:938	relatively low thermal conductivity of 32.0-37.7 mW·m-1·K-1	904:962	The CNF/PCM composite aerogel showed relatively low thermal conductivity of 32.0-37.7 mW·m-1·K-1.
34420720	3	14	theme	PCM	313:315	arg1	aerogel					317:323	a lightweight, strong, and form-stable PCM aerogel	274:323	a lightweight, strong, and form-stable PCM aerogel	274:323	Herein, a lightweight, strong, and form-stable PCM aerogel was fabricated using Pickering emulsion templating technique.
34420720	8	15	theme	composite	1044:1052	arg1	aerogel					1054:1060	the CNF/PCM composite aerogel	1032:1060	the CNF/PCM composite aerogel	1032:1060	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
34420720	8	16	theme	impressive	988:997	arg1	properties					1018:1027	The sustainability and impressive thermal regulating properties	965:1027	properties	1018:1027	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
34420720	0	17	theme	Lightweight	0:10	arg1	nanofibrils					47:57	Lightweight, strong, and form-stable cellulose nanofibrils	0:57	Lightweight, strong, and form-stable cellulose nanofibrils	0:57	Lightweight, strong, and form-stable cellulose nanofibrils phase change aerogel with high latent heat.
34420720	1	18	theme	energy	148:153	arg1	storage					155:161	energy storage	148:161	energy storage	148:161	Phase change material (PCM) is promising for energy storage and release.
34420720	3	19	theme	Pickering	346:354	arg1	technique					376:384	Pickering emulsion templating technique	346:384	Pickering emulsion templating technique	346:384	Herein, a lightweight, strong, and form-stable PCM aerogel was fabricated using Pickering emulsion templating technique.
34420720	4	20	used	used	421:424	arg2	nanofibrils					397:407	Cellulose nanofibrils	387:407	Cellulose nanofibrils (CNFs)	387:414	Cellulose nanofibrils (CNFs) were used to stabilize PCM into Pickering emulsion, which was further integrated into a 3D interconnected CNF network forming CNF/PCM composite aerogel.
34420720	4	20	used	used	421:424	arg2	CNFs					410:413	CNFs	410:413	CNFs	410:413	Cellulose nanofibrils (CNFs) were used to stabilize PCM into Pickering emulsion, which was further integrated into a 3D interconnected CNF network forming CNF/PCM composite aerogel.
34420720	5	21	theme	own	641:643	arg1	weight					645:650	its own weight	637:650	its own weight	637:650	The composite aerogel is strong that can support over 5000 times of its own weight, and demonstrates exceptional form stability at 80 °C, showing no leakage after 20 heating/cooling cycles.
34420720	7	22	theme	low	915:917	arg1	conductivity					927:938	relatively low thermal conductivity	904:938	relatively low thermal conductivity of 32.0-37.7 mW·m-1·K-1	904:962	The CNF/PCM composite aerogel showed relatively low thermal conductivity of 32.0-37.7 mW·m-1·K-1.
34420720	3	23	theme	emulsion	356:363	arg1	technique					376:384	Pickering emulsion templating technique	346:384	Pickering emulsion templating technique	346:384	Herein, a lightweight, strong, and form-stable PCM aerogel was fabricated using Pickering emulsion templating technique.
34420720	4	24	theme	CNF	522:524	arg1	network					526:532	a 3D interconnected CNF network	502:532	a 3D interconnected CNF network forming CNF/PCM composite aerogel	502:566	Cellulose nanofibrils (CNFs) were used to stabilize PCM into Pickering emulsion, which was further integrated into a 3D interconnected CNF network forming CNF/PCM composite aerogel.
34420720	7	25	theme	composite	879:887	arg1	aerogel					889:895	The CNF/PCM composite aerogel	867:895	The CNF/PCM composite aerogel	867:895	The CNF/PCM composite aerogel showed relatively low thermal conductivity of 32.0-37.7 mW·m-1·K-1.
34420720	8	26	theme	regulating	1007:1016	arg1	properties					1018:1027	The sustainability and impressive thermal regulating properties	965:1027	properties	1018:1027	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
34420720	4	27	theme	interconnected	507:520	arg1	network					526:532	a 3D interconnected CNF network	502:532	a 3D interconnected CNF network forming CNF/PCM composite aerogel	502:566	Cellulose nanofibrils (CNFs) were used to stabilize PCM into Pickering emulsion, which was further integrated into a 3D interconnected CNF network forming CNF/PCM composite aerogel.
34420720	8	28	theme	ideal	1073:1077	arg1	candidate					1079:1087	an ideal candidate	1070:1087	an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices	1070:1172	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
34420720	8	29	theme	thermal	999:1005	arg1	properties					1018:1027	The sustainability and impressive thermal regulating properties	965:1027	properties	1018:1027	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
34420720	0	30	theme	strong	13:18	arg1	nanofibrils					47:57	Lightweight, strong, and form-stable cellulose nanofibrils	0:57	Lightweight, strong, and form-stable cellulose nanofibrils	0:57	Lightweight, strong, and form-stable cellulose nanofibrils phase change aerogel with high latent heat.
34420720	5	31	from	80 °C	700:704	arg1	stability					687:695	exceptional form stability	670:695	exceptional form stability at 80 °C	670:704	The composite aerogel is strong that can support over 5000 times of its own weight, and demonstrates exceptional form stability at 80 °C, showing no leakage after 20 heating/cooling cycles.
34420720	0	32	theme	form-stable	25:35	arg1	nanofibrils					47:57	Lightweight, strong, and form-stable cellulose nanofibrils	0:57	Lightweight, strong, and form-stable cellulose nanofibrils	0:57	Lightweight, strong, and form-stable cellulose nanofibrils phase change aerogel with high latent heat.
34420720	5	33	theme	exceptional	670:680	arg1	stability					687:695	exceptional form stability	670:695	exceptional form stability at 80 °C	670:704	The composite aerogel is strong that can support over 5000 times of its own weight, and demonstrates exceptional form stability at 80 °C, showing no leakage after 20 heating/cooling cycles.
34420720	2	34	theme	leaking	205:211	arg1	change					226:231	the deformation and leaking during phase change	185:231	the deformation and leaking during phase change	185:231	However, the deformation and leaking during phase change generally limit its application.
34420720	5	35	theme	heating/cooling	735:749	arg1	cycles					751:756	20 heating/cooling cycles	732:756	20 heating/cooling cycles	732:756	The composite aerogel is strong that can support over 5000 times of its own weight, and demonstrates exceptional form stability at 80 °C, showing no leakage after 20 heating/cooling cycles.
34420720	5	36	theme	form	682:685	arg1	stability					687:695	exceptional form stability	670:695	exceptional form stability at 80 °C	670:704	The composite aerogel is strong that can support over 5000 times of its own weight, and demonstrates exceptional form stability at 80 °C, showing no leakage after 20 heating/cooling cycles.
34420720	3	37	theme	templating	365:374	arg1	technique					376:384	Pickering emulsion templating technique	346:384	Pickering emulsion templating technique	346:384	Herein, a lightweight, strong, and form-stable PCM aerogel was fabricated using Pickering emulsion templating technique.
34420720	6	38	theme	latent	763:768	arg1	heat					770:773	The latent heat	759:773	The latent heat of CNF/PCM composite aerogel	759:802	The latent heat of CNF/PCM composite aerogel could reach 173.59 J·g-1, approximately 84.4% of the paraffin.
34420720	2	39	theme	deformation	189:199	arg1	change					226:231	the deformation and leaking during phase change	185:231	the deformation and leaking during phase change	185:231	However, the deformation and leaking during phase change generally limit its application.
34420720	8	40	theme	textile	1115:1121	arg1	building					1130:1137	smart textile, smart building	1109:1137	smart textile, smart building	1109:1137	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
34420720	1	41	theme	Phase	103:107	arg1	material					116:123	Phase change material	103:123	Phase change material (PCM)	103:129	Phase change material (PCM) is promising for energy storage and release.
34420720	1	41	theme	Phase	103:107	arg1	PCM					126:128	PCM	126:128	PCM	126:128	Phase change material (PCM) is promising for energy storage and release.
34420720	0	42	theme	cellulose	37:45	arg1	nanofibrils					47:57	Lightweight, strong, and form-stable cellulose nanofibrils	0:57	Lightweight, strong, and form-stable cellulose nanofibrils	0:57	Lightweight, strong, and form-stable cellulose nanofibrils phase change aerogel with high latent heat.
34420720	4	43	theme	3D	504:505	arg1	network					526:532	a 3D interconnected CNF network	502:532	a 3D interconnected CNF network forming CNF/PCM composite aerogel	502:566	Cellulose nanofibrils (CNFs) were used to stabilize PCM into Pickering emulsion, which was further integrated into a 3D interconnected CNF network forming CNF/PCM composite aerogel.
34420720	3	44	theme	lightweight	276:286	arg1	aerogel					317:323	a lightweight, strong, and form-stable PCM aerogel	274:323	a lightweight, strong, and form-stable PCM aerogel	274:323	Herein, a lightweight, strong, and form-stable PCM aerogel was fabricated using Pickering emulsion templating technique.
34420720	1	45	theme	change	109:114	arg1	material					116:123	Phase change material	103:123	Phase change material (PCM)	103:129	Phase change material (PCM) is promising for energy storage and release.
34420720	1	45	theme	change	109:114	arg1	PCM					126:128	PCM	126:128	PCM	126:128	Phase change material (PCM) is promising for energy storage and release.
34420720	5	46	theme	weight	645:650	arg1	times					628:632	5000 times	623:632	5000 times of its own weight	623:650	The composite aerogel is strong that can support over 5000 times of its own weight, and demonstrates exceptional form stability at 80 °C, showing no leakage after 20 heating/cooling cycles.
34420720	6	47	theme	aerogel	796:802	arg1	heat					770:773	The latent heat	759:773	The latent heat of CNF/PCM composite aerogel	759:802	The latent heat of CNF/PCM composite aerogel could reach 173.59 J·g-1, approximately 84.4% of the paraffin.
34420720	5	48	theme	composite	573:581	arg1	strong					594:599	strong	594:599	strong	594:599	The composite aerogel is strong that can support over 5000 times of its own weight, and demonstrates exceptional form stability at 80 °C, showing no leakage after 20 heating/cooling cycles.
34420720	5	48	theme	composite	573:581	arg1	aerogel					583:589	The composite aerogel	569:589	The composite aerogel	569:589	The composite aerogel is strong that can support over 5000 times of its own weight, and demonstrates exceptional form stability at 80 °C, showing no leakage after 20 heating/cooling cycles.
34420720	7	49	theme	CNF/PCM	871:877	arg1	aerogel					889:895	The CNF/PCM composite aerogel	867:895	The CNF/PCM composite aerogel	867:895	The CNF/PCM composite aerogel showed relatively low thermal conductivity of 32.0-37.7 mW·m-1·K-1.
34420720	6	50	theme	composite	786:794	arg1	aerogel					796:802	CNF/PCM composite aerogel	778:802	CNF/PCM composite aerogel	778:802	The latent heat of CNF/PCM composite aerogel could reach 173.59 J·g-1, approximately 84.4% of the paraffin.
34420720	0	51	theme	change	65:70	arg1	aerogel					72:78	phase change aerogel	59:78	phase change aerogel	59:78	Lightweight, strong, and form-stable cellulose nanofibrils phase change aerogel with high latent heat.
34420720	6	52	theme	CNF/PCM	778:784	arg1	aerogel					796:802	CNF/PCM composite aerogel	778:802	CNF/PCM composite aerogel	778:802	The latent heat of CNF/PCM composite aerogel could reach 173.59 J·g-1, approximately 84.4% of the paraffin.
34420720	8	53	theme	electronic	1155:1164	arg1	devices					1166:1172	electronic devices	1155:1172	electronic devices	1155:1172	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
34420720	0	54	theme	phase	59:63	arg1	aerogel					72:78	phase change aerogel	59:78	phase change aerogel	59:78	Lightweight, strong, and form-stable cellulose nanofibrils phase change aerogel with high latent heat.
34420720	7	55	theme	32.0-37.7 mW·m-1·K-1	943:962	arg1	conductivity					927:938	relatively low thermal conductivity	904:938	relatively low thermal conductivity of 32.0-37.7 mW·m-1·K-1	904:962	The CNF/PCM composite aerogel showed relatively low thermal conductivity of 32.0-37.7 mW·m-1·K-1.
34420720	8	56	dep	textile	1115:1121	arg1	smart					1124:1128	smart	1124:1128	smart	1124:1128	The sustainability and impressive thermal regulating properties of the CNF/PCM composite aerogel make it an ideal candidate for applications in smart textile, smart building, batteries, and electronic devices.
32088236	4	0	theme	branch-shaped	935:947	arg1	structure					949:957	well-defined branch-shaped structure	922:957	well-defined branch-shaped structure	922:957	The images of scanning electron microscope show the composite coating with a thickness of 50 μm has well-defined branch-shaped structure.
32088236	2	1	theme	aluminum	539:546	arg1	alloy					548:552	aluminum alloy	539:552	aluminum alloy in 3.5 wt% NaCl solution	539:577	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	4	2	theme	electron	845:852	arg1	microscope					854:863	scanning electron microscope	836:863	scanning electron microscope	836:863	The images of scanning electron microscope show the composite coating with a thickness of 50 μm has well-defined branch-shaped structure.
32088236	0	3	theme	aluminum	82:89	arg1	protection					61:70	corrosion protection	51:70	corrosion protection of AA5052 aluminum	51:89	A self-curing konjac glucomannan/CaCO3 coating for corrosion protection of AA5052 aluminum alloy in NaCl solution.
32088236	6	4	theme	electrochemical	1083:1097	arg1	spectroscopy					1109:1120	electrochemical impedance spectroscopy	1083:1120	electrochemical impedance spectroscopy	1083:1120	The results of electrochemical impedance spectroscopy suggest that the resistance of the aluminum alloy sample coated with such protective layer is improved by six orders of magnitude, compared with the bare metal.
32088236	3	5	theme	atomic	791:796	arg1	AFM					816:818	AFM	816:818	AFM	816:818	Moreover, the inhibitory performance of the coating on the pitting corrosion of metal was examined by potentiodynamic polarization curves and atomic force microscopy (AFM).
32088236	3	5	theme	atomic	791:796	arg1	microscopy					804:813	atomic force microscopy	791:813	atomic force microscopy (AFM)	791:819	Moreover, the inhibitory performance of the coating on the pitting corrosion of metal was examined by potentiodynamic polarization curves and atomic force microscopy (AFM).
32088236	0	6	theme	NaCl	100:103	arg1	solution					105:112	NaCl solution	100:112	NaCl solution	100:112	A self-curing konjac glucomannan/CaCO3 coating for corrosion protection of AA5052 aluminum alloy in NaCl solution.
32088236	2	7	theme	coating	527:533	arg1	property					501:508	the protective property	486:508	the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution	486:577	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	7	8	theme	curve	1325:1329	arg1	data					1331:1334	the polarization curve data	1308:1334	the polarization curve data	1308:1334	After 60 d of immersion, the polarization curve data and AFM analysis show the pitting corrosion occurring on AA5052 surface is prevented due to the barrier property of coating.
32088236	6	9	theme	aluminum	1157:1164	arg1	sample					1172:1177	the aluminum alloy sample	1153:1177	the aluminum alloy sample coated with such protective layer	1153:1211	The results of electrochemical impedance spectroscopy suggest that the resistance of the aluminum alloy sample coated with such protective layer is improved by six orders of magnitude, compared with the bare metal.
32088236	3	10	theme	polarization	767:778	arg1	curves					780:785	potentiodynamic polarization curves	751:785	potentiodynamic polarization curves	751:785	Moreover, the inhibitory performance of the coating on the pitting corrosion of metal was examined by potentiodynamic polarization curves and atomic force microscopy (AFM).
32088236	2	11	theme	OH	470:471	arg1	content					475:481	Ca(OH)2 content	467:481	Ca(OH)2 content	467:481	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	2	12	theme	composite	517:525	arg1	coating					527:533	the composite coating	513:533	the composite coating for aluminum alloy in 3.5 wt% NaCl solution	513:577	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	4	13	with	coating	884:890	arg1	thickness					899:907	a thickness	897:907	a thickness of 50 μm	897:916	The images of scanning electron microscope show the composite coating with a thickness of 50 μm has well-defined branch-shaped structure.
32088236	1	14	theme	surface	251:257	arg1	morphology					259:268	surface morphology	251:268	surface morphology	251:268	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	5	15	theme	CaCO3	1061:1065	arg1	formation					1048:1056	the formation	1044:1056	the formation of CaCO3	1044:1065	The FT-IR spectra confirm the successful fabrication of the polymer coating through the formation of CaCO3.
32088236	2	16	theme	%	563:563	arg1	solution					570:577	3.5 wt% NaCl solution	557:577	3.5 wt% NaCl solution	557:577	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	1	17	theme	thermogravimetric	419:435	arg1	TGA					447:449	TGA	447:449	TGA	447:449	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	1	17	theme	thermogravimetric	419:435	arg1	analysis					437:444	thermogravimetric analysis	419:444	thermogravimetric analysis (TGA)	419:450	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	2	18	theme	Ca	467:468	arg1	content					475:481	Ca(OH)2 content	467:481	Ca(OH)2 content	467:481	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	2	19	theme	3.5 wt	557:562	arg1	solution					570:577	3.5 wt% NaCl solution	557:577	3.5 wt% NaCl solution	557:577	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	2	20	theme	spectroscopy	622:633	arg1	measurements					635:646	electrochemical impedance spectroscopy measurements	596:646	electrochemical impedance spectroscopy measurements	596:646	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	3	21	theme	pitting	708:714	arg1	corrosion					716:724	the pitting corrosion	704:724	the pitting corrosion of metal	704:733	Moreover, the inhibitory performance of the coating on the pitting corrosion of metal was examined by potentiodynamic polarization curves and atomic force microscopy (AFM).
32088236	0	22	theme	self-curing	2:12	arg1	coating					39:45	A self-curing konjac glucomannan/CaCO3 coating	0:45	A self-curing konjac glucomannan/CaCO3 coating for corrosion protection of AA5052 aluminum	0:89	A self-curing konjac glucomannan/CaCO3 coating for corrosion protection of AA5052 aluminum alloy in NaCl solution.
32088236	3	23	theme	inhibitory	663:672	arg1	performance					674:684	the inhibitory performance	659:684	the inhibitory performance of the coating on the pitting corrosion of metal	659:733	Moreover, the inhibitory performance of the coating on the pitting corrosion of metal was examined by potentiodynamic polarization curves and atomic force microscopy (AFM).
32088236	2	24	theme	impedance	612:620	arg1	measurements					635:646	electrochemical impedance spectroscopy measurements	596:646	electrochemical impedance spectroscopy measurements	596:646	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	7	25	theme	coating	1452:1458	arg1	property					1440:1447	the barrier property	1428:1447	the barrier property of coating	1428:1458	After 60 d of immersion, the polarization curve data and AFM analysis show the pitting corrosion occurring on AA5052 surface is prevented due to the barrier property of coating.
32088236	2	26	theme	electrochemical	596:610	arg1	measurements					635:646	electrochemical impedance spectroscopy measurements	596:646	electrochemical impedance spectroscopy measurements	596:646	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	7	27	theme	pitting	1362:1368	arg1	corrosion					1370:1378	the pitting corrosion	1358:1378	the pitting corrosion occurring on AA5052 surface	1358:1406	After 60 d of immersion, the polarization curve data and AFM analysis show the pitting corrosion occurring on AA5052 surface is prevented due to the barrier property of coating.
32088236	0	28	theme	glucomannan/CaCO3	21:37	arg1	coating					39:45	A self-curing konjac glucomannan/CaCO3 coating	0:45	A self-curing konjac glucomannan/CaCO3 coating for corrosion protection of AA5052 aluminum	0:89	A self-curing konjac glucomannan/CaCO3 coating for corrosion protection of AA5052 aluminum alloy in NaCl solution.
32088236	7	29	theme	immersion	1297:1305	arg1	60 d					1289:1292	60 d	1289:1292	60 d of immersion	1289:1305	After 60 d of immersion, the polarization curve data and AFM analysis show the pitting corrosion occurring on AA5052 surface is prevented due to the barrier property of coating.
32088236	2	30	theme	NaCl	565:568	arg1	solution					570:577	3.5 wt% NaCl solution	557:577	3.5 wt% NaCl solution	557:577	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	0	31	theme	konjac	14:19	arg1	coating					39:45	A self-curing konjac glucomannan/CaCO3 coating	0:45	A self-curing konjac glucomannan/CaCO3 coating for corrosion protection of AA5052 aluminum	0:89	A self-curing konjac glucomannan/CaCO3 coating for corrosion protection of AA5052 aluminum alloy in NaCl solution.
32088236	5	32	theme	coating	1028:1034	arg1	fabrication					1001:1011	the successful fabrication	986:1011	the successful fabrication of the polymer coating	986:1034	The FT-IR spectra confirm the successful fabrication of the polymer coating through the formation of CaCO3.
32088236	6	33	theme	spectroscopy	1109:1120	arg1	results					1072:1078	The results	1068:1078	The results of electrochemical impedance spectroscopy	1068:1120	The results of electrochemical impedance spectroscopy suggest that the resistance of the aluminum alloy sample coated with such protective layer is improved by six orders of magnitude, compared with the bare metal.
32088236	4	34	dep	show	865:868	arg1	has					918:920	has	918:920	show the composite coating with a thickness of 50 μm has well-defined branch-shaped structure	865:957	The images of scanning electron microscope show the composite coating with a thickness of 50 μm has well-defined branch-shaped structure.
32088236	3	35	theme	coating	693:699	arg1	performance					674:684	the inhibitory performance	659:684	the inhibitory performance of the coating on the pitting corrosion of metal	659:733	Moreover, the inhibitory performance of the coating on the pitting corrosion of metal was examined by potentiodynamic polarization curves and atomic force microscopy (AFM).
32088236	2	36	theme	content	475:481	arg1	effect					457:462	The effect	453:462	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution	453:577	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	6	37	theme	alloy	1166:1170	arg1	sample					1172:1177	the aluminum alloy sample	1153:1177	the aluminum alloy sample coated with such protective layer	1153:1211	The results of electrochemical impedance spectroscopy suggest that the resistance of the aluminum alloy sample coated with such protective layer is improved by six orders of magnitude, compared with the bare metal.
32088236	1	38	dep	transform	350:358	arg1	infrared					360:367	infrared	360:367	transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA)	350:450	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	4	39	theme	composite	874:882	arg1	coating					884:890	the composite coating	870:890	the composite coating with a thickness of 50 μm	870:916	The images of scanning electron microscope show the composite coating with a thickness of 50 μm has well-defined branch-shaped structure.
32088236	3	40	from	performance	674:684	arg1	corrosion					716:724	the pitting corrosion	704:724	the pitting corrosion of metal	704:733	Moreover, the inhibitory performance of the coating on the pitting corrosion of metal was examined by potentiodynamic polarization curves and atomic force microscopy (AFM).
32088236	1	41	dep	Fourier	342:348	arg1	transform					350:358	transform	350:358	transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA)	350:450	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	2	42	from	alloy	548:552	arg1	solution					570:577	3.5 wt% NaCl solution	557:577	3.5 wt% NaCl solution	557:577	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	4	43	theme	scanning	836:843	arg1	microscope					854:863	scanning electron microscope	836:863	scanning electron microscope	836:863	The images of scanning electron microscope show the composite coating with a thickness of 50 μm has well-defined branch-shaped structure.
32088236	2	44	from	effect	457:462	arg1	property					501:508	the protective property	486:508	the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution	486:577	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	6	45	theme	protective	1196:1205	arg1	layer					1207:1211	such protective layer	1191:1211	such protective layer	1191:1211	The results of electrochemical impedance spectroscopy suggest that the resistance of the aluminum alloy sample coated with such protective layer is improved by six orders of magnitude, compared with the bare metal.
32088236	6	46	theme	impedance	1099:1107	arg1	spectroscopy					1109:1120	electrochemical impedance spectroscopy	1083:1120	electrochemical impedance spectroscopy	1083:1120	The results of electrochemical impedance spectroscopy suggest that the resistance of the aluminum alloy sample coated with such protective layer is improved by six orders of magnitude, compared with the bare metal.
32088236	0	47	theme	corrosion	51:59	arg1	protection					61:70	corrosion protection	51:70	corrosion protection of AA5052 aluminum	51:89	A self-curing konjac glucomannan/CaCO3 coating for corrosion protection of AA5052 aluminum alloy in NaCl solution.
32088236	1	48	theme	scanning	306:313	arg1	SEM					336:338	SEM	336:338	SEM	336:338	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	1	48	theme	scanning	306:313	arg1	Fourier					342:348	Fourier	342:348	Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA)	342:450	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	1	48	theme	scanning	306:313	arg1	microscope					324:333	scanning electron microscope	306:333	scanning electron microscope (SEM)	306:339	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	7	49	theme	barrier	1432:1438	arg1	property					1440:1447	the barrier property	1428:1447	the barrier property of coating	1428:1458	After 60 d of immersion, the polarization curve data and AFM analysis show the pitting corrosion occurring on AA5052 surface is prevented due to the barrier property of coating.
32088236	5	50	theme	successful	990:999	arg1	fabrication					1001:1011	the successful fabrication	986:1011	the successful fabrication of the polymer coating	986:1034	The FT-IR spectra confirm the successful fabrication of the polymer coating through the formation of CaCO3.
32088236	1	51	theme	composite	117:125	arg1	coating					127:133	A composite coating	115:133	A composite coating containing konjac glucomannan (KGM) and CaCO3	115:179	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	6	52	theme	such	1191:1194	arg1	layer					1207:1211	such protective layer	1191:1211	such protective layer	1191:1211	The results of electrochemical impedance spectroscopy suggest that the resistance of the aluminum alloy sample coated with such protective layer is improved by six orders of magnitude, compared with the bare metal.
32088236	1	53	theme	electron	315:322	arg1	SEM					336:338	SEM	336:338	SEM	336:338	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	1	53	theme	electron	315:322	arg1	Fourier					342:348	Fourier	342:348	Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA)	342:450	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	1	53	theme	electron	315:322	arg1	microscope					324:333	scanning electron microscope	306:333	scanning electron microscope (SEM)	306:339	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	4	54	theme	microscope	854:863	arg1	images					826:831	The images	822:831	The images of scanning electron microscope	822:863	The images of scanning electron microscope show the composite coating with a thickness of 50 μm has well-defined branch-shaped structure.
32088236	1	55	theme	X-ray	391:395	arg1	XRD					410:412	XRD	410:412	XRD	410:412	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	1	55	theme	X-ray	391:395	arg1	diffraction					397:407	X-ray diffraction	391:407	X-ray diffraction (XRD)	391:413	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	7	56	theme	AFM	1340:1342	arg1	analysis					1344:1351	AFM analysis	1340:1351	AFM analysis	1340:1351	After 60 d of immersion, the polarization curve data and AFM analysis show the pitting corrosion occurring on AA5052 surface is prevented due to the barrier property of coating.
32088236	4	57	theme	well-defined	922:933	arg1	structure					949:957	well-defined branch-shaped structure	922:957	well-defined branch-shaped structure	922:957	The images of scanning electron microscope show the composite coating with a thickness of 50 μm has well-defined branch-shaped structure.
32088236	2	58	theme	protective	490:499	arg1	property					501:508	the protective property	486:508	the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution	486:577	The effect of Ca(OH)2 content on the protective property of the composite coating for aluminum alloy in 3.5 wt% NaCl solution was evaluated by electrochemical impedance spectroscopy measurements.
32088236	7	59	theme	polarization	1312:1323	arg1	data					1331:1334	the polarization curve data	1308:1334	the polarization curve data	1308:1334	After 60 d of immersion, the polarization curve data and AFM analysis show the pitting corrosion occurring on AA5052 surface is prevented due to the barrier property of coating.
32088236	3	60	theme	force	798:802	arg1	AFM					816:818	AFM	816:818	AFM	816:818	Moreover, the inhibitory performance of the coating on the pitting corrosion of metal was examined by potentiodynamic polarization curves and atomic force microscopy (AFM).
32088236	3	60	theme	force	798:802	arg1	microscopy					804:813	atomic force microscopy	791:813	atomic force microscopy (AFM)	791:819	Moreover, the inhibitory performance of the coating on the pitting corrosion of metal was examined by potentiodynamic polarization curves and atomic force microscopy (AFM).
32088236	3	61	theme	potentiodynamic	751:765	arg1	curves					780:785	potentiodynamic polarization curves	751:785	potentiodynamic polarization curves	751:785	Moreover, the inhibitory performance of the coating on the pitting corrosion of metal was examined by potentiodynamic polarization curves and atomic force microscopy (AFM).
32088236	5	62	theme	polymer	1020:1026	arg1	coating					1028:1034	the polymer coating	1016:1034	the polymer coating	1016:1034	The FT-IR spectra confirm the successful fabrication of the polymer coating through the formation of CaCO3.
32088236	6	63	theme	sample	1172:1177	arg1	resistance					1139:1148	the resistance	1135:1148	the resistance of the aluminum alloy sample coated with such protective layer	1135:1211	The results of electrochemical impedance spectroscopy suggest that the resistance of the aluminum alloy sample coated with such protective layer is improved by six orders of magnitude, compared with the bare metal.
32088236	1	64	theme	konjac	146:151	arg1	glucomannan					153:163	konjac glucomannan	146:163	konjac glucomannan (KGM)	146:169	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	1	64	theme	konjac	146:151	arg1	KGM					166:168	KGM	166:168	KGM	166:168	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	1	65	theme	self-curing	222:232	arg1	process					234:240	a self-curing process	220:240	a self-curing process	220:240	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	4	66	theme	50 μm	912:916	arg1	thickness					899:907	a thickness	897:907	a thickness of 50 μm	897:916	The images of scanning electron microscope show the composite coating with a thickness of 50 μm has well-defined branch-shaped structure.
32088236	1	67	contain	containing	135:144	arg1	coating					127:133	A composite coating	115:133	A composite coating containing konjac glucomannan (KGM) and CaCO3	115:179	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	1	67	contain	containing	135:144	arg2	KGM					166:168	KGM	166:168	KGM	166:168	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	1	67	contain	containing	135:144	arg2	glucomannan					153:163	konjac glucomannan	146:163	konjac glucomannan (KGM)	146:169	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	1	67	contain	containing	135:144	arg2	CaCO3					175:179	CaCO3	175:179	CaCO3	175:179	A composite coating containing konjac glucomannan (KGM) and CaCO3 was fabricated on AA5052 alloy through a self-curing process, and its surface morphology and component were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA).
32088236	5	68	theme	FT-IR	964:968	arg1	spectra					970:976	The FT-IR spectra	960:976	The FT-IR spectra	960:976	The FT-IR spectra confirm the successful fabrication of the polymer coating through the formation of CaCO3.
32088236	7	69	dep	show	1353:1356	arg1	prevented					1411:1419	prevented	1411:1419	show the pitting corrosion occurring on AA5052 surface is prevented due to the barrier property of coating	1353:1458	After 60 d of immersion, the polarization curve data and AFM analysis show the pitting corrosion occurring on AA5052 surface is prevented due to the barrier property of coating.
32088236	6	70	theme	magnitude	1242:1250	arg1	orders					1232:1237	six orders	1228:1237	six orders of magnitude	1228:1250	The results of electrochemical impedance spectroscopy suggest that the resistance of the aluminum alloy sample coated with such protective layer is improved by six orders of magnitude, compared with the bare metal.
32088236	3	71	theme	metal	729:733	arg1	corrosion					716:724	the pitting corrosion	704:724	the pitting corrosion of metal	704:733	Moreover, the inhibitory performance of the coating on the pitting corrosion of metal was examined by potentiodynamic polarization curves and atomic force microscopy (AFM).
31953177	3	0	theme	PAMAM	341:345	arg1	pH					347:348	The optimum PAMAM pH	329:348	The optimum PAMAM pH	329:348	The optimum PAMAM pH was at 2.1 and 9.3.
31953177	5	1	theme	optimization	531:542	arg1	yield					572:576	the maximum immobilization yield	545:576	the maximum immobilization yield	545:576	As a result of central composite design optimization, the maximum immobilization yield was obtained by soaking 8 U for 24 h.
31953177	5	1	theme	optimization	531:542	arg1	result					496:501	a result	494:501	a result of central composite design optimization	494:542	As a result of central composite design optimization, the maximum immobilization yield was obtained by soaking 8 U for 24 h.
31953177	1	2	theme	high	169:172	arg1	density					174:180	a high density	167:180	a high density of surface amino groups	167:204	Hyperbranched polyamidoamine (PAMAM) has a high density of surface amino groups.
31953177	6	3	theme	comparative	620:630	arg1	studies					647:653	The comparative thermodynamics studies	616:653	The comparative thermodynamics studies	616:653	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	0	4	theme	Thermodynamics	88:101	arg1	studies					117:123	Thermodynamics and stability studies	88:123	Functionalized κ-carrageenan/hyperbranched poly(amidoamine)for protease immobilization: Thermodynamics and stability studies.	0:124	Functionalized κ-carrageenan/hyperbranched poly(amidoamine)for protease immobilization: Thermodynamics and stability studies.
31953177	9	5	theme	used	1273:1276	arg1	film					1284:1287	used X-ray film	1273:1287	used X-ray film by the immobilized protease	1273:1315	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	4	6	theme	gel	406:408	arg1	beads					410:414	κ-carrageenan gel beads	392:414	κ-carrageenan gel beads	392:414	However, treatment of κ-carrageenan gel beads at the higher pH showed re-usability for more than seven successive times.
31953177	7	7	theme	free	879:882	arg1	enzyme					900:905	free and immobilized enzyme	879:905	free and immobilized enzyme	879:905	Also, the D-values increased from 165.03 min to 548.23 min for free and immobilized enzyme, respectively.
31953177	2	8	theme	κ-carrageenan	265:277	arg1	beads					283:287	κ-carrageenan gel beads	265:287	κ-carrageenan gel beads	265:287	This feature was exploited in the surface modification of κ-carrageenan gel beads for successful protease immobilization.
31953177	4	9	theme	κ-carrageenan	392:404	arg1	beads					410:414	κ-carrageenan gel beads	392:414	κ-carrageenan gel beads	392:414	However, treatment of κ-carrageenan gel beads at the higher pH showed re-usability for more than seven successive times.
31953177	2	10	theme	protease	304:311	arg1	immobilization					313:326	successful protease immobilization	293:326	successful protease immobilization	293:326	This feature was exploited in the surface modification of κ-carrageenan gel beads for successful protease immobilization.
31953177	0	11	theme	stability	107:115	arg1	studies					117:123	Thermodynamics and stability studies	88:123	Functionalized κ-carrageenan/hyperbranched poly(amidoamine)for protease immobilization: Thermodynamics and stability studies.	0:124	Functionalized κ-carrageenan/hyperbranched poly(amidoamine)for protease immobilization: Thermodynamics and stability studies.
31953177	4	12	theme	successive	473:482	arg1	times					484:488	more than seven successive times	457:488	more than seven successive times	457:488	However, treatment of κ-carrageenan gel beads at the higher pH showed re-usability for more than seven successive times.
31953177	8	13	theme	enzyme	936:941	arg1	enhancement					953:963	the enzyme stability enhancement	932:963	the enzyme stability enhancement for the immobilized protease catalyst	932:1001	Moreover, the enzyme stability enhancement for the immobilized protease catalyst was accompanied with a remarkable increase in the enthalpy and in the free energy.
31953177	2	14	theme	successful	293:302	arg1	immobilization					313:326	successful protease immobilization	293:326	successful protease immobilization	293:326	This feature was exploited in the surface modification of κ-carrageenan gel beads for successful protease immobilization.
31953177	9	15	from	8 weeks	1196:1202	arg1	4 °C.					1218:1222	4 °C.	1218:1222	4 °C.	1218:1222	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	4	16	theme	beads	410:414	arg1	treatment					379:387	treatment	379:387	treatment of κ-carrageenan gel beads at the higher pH	379:431	However, treatment of κ-carrageenan gel beads at the higher pH showed re-usability for more than seven successive times.
31953177	9	17	theme	Immobilized	1086:1096	arg1	protease					1098:1105	Immobilized protease	1086:1105	Immobilized protease onto Carr-PAMAM gel beads	1086:1131	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	9	18	theme	storage	1207:1213	arg1	8 weeks					1196:1202	8 weeks	1196:1202	8 weeks of storage at 4 °C.	1196:1222	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	2	19	theme	beads	283:287	arg1	modification					249:260	the surface modification	237:260	the surface modification of κ-carrageenan gel beads	237:287	This feature was exploited in the surface modification of κ-carrageenan gel beads for successful protease immobilization.
31953177	6	20	theme	high	705:708	arg1	temperature					710:720	high temperature	705:720	high temperature for the immobilized protease	705:749	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	1	21	theme	surface	185:191	arg1	groups					199:204	surface amino groups	185:204	surface amino groups	185:204	Hyperbranched polyamidoamine (PAMAM) has a high density of surface amino groups.
31953177	0	22	theme	κ-carrageenan/hyperbranched	15:41	arg1	poly					43:46	Functionalized κ-carrageenan/hyperbranched poly	0:46	Functionalized κ-carrageenan/hyperbranched poly(amidoamine)for protease immobilization: Thermodynamics and stability studies.	0:124	Functionalized κ-carrageenan/hyperbranched poly(amidoamine)for protease immobilization: Thermodynamics and stability studies.
31953177	0	22	theme	κ-carrageenan/hyperbranched	15:41	arg1	amidoamine					48:57	amidoamine	48:57	amidoamine	48:57	Functionalized κ-carrageenan/hyperbranched poly(amidoamine)for protease immobilization: Thermodynamics and stability studies.
31953177	1	23	contain	has	163:165	arg2	density					174:180	a high density	167:180	a high density of surface amino groups	167:204	Hyperbranched polyamidoamine (PAMAM) has a high density of surface amino groups.
31953177	1	23	contain	has	163:165	arg1	PAMAM					156:160	PAMAM	156:160	PAMAM	156:160	Hyperbranched polyamidoamine (PAMAM) has a high density of surface amino groups.
31953177	1	23	contain	has	163:165	arg1	polyamidoamine					140:153	Hyperbranched polyamidoamine	126:153	Hyperbranched polyamidoamine (PAMAM)	126:161	Hyperbranched polyamidoamine (PAMAM) has a high density of surface amino groups.
31953177	4	24	from	pH	430:431	arg1	treatment					379:387	treatment	379:387	treatment of κ-carrageenan gel beads at the higher pH	379:431	However, treatment of κ-carrageenan gel beads at the higher pH showed re-usability for more than seven successive times.
31953177	1	25	theme	amino	193:197	arg1	groups					199:204	surface amino groups	185:204	surface amino groups	185:204	Hyperbranched polyamidoamine (PAMAM) has a high density of surface amino groups.
31953177	0	26	theme	Functionalized	0:13	arg1	poly					43:46	Functionalized κ-carrageenan/hyperbranched poly	0:46	Functionalized κ-carrageenan/hyperbranched poly(amidoamine)for protease immobilization: Thermodynamics and stability studies.	0:124	Functionalized κ-carrageenan/hyperbranched poly(amidoamine)for protease immobilization: Thermodynamics and stability studies.
31953177	0	26	theme	Functionalized	0:13	arg1	amidoamine					48:57	amidoamine	48:57	amidoamine	48:57	Functionalized κ-carrageenan/hyperbranched poly(amidoamine)for protease immobilization: Thermodynamics and stability studies.
31953177	8	27	theme	free	1073:1076	arg1	energy					1078:1083	the free energy	1069:1083	the free energy	1069:1083	Moreover, the enzyme stability enhancement for the immobilized protease catalyst was accompanied with a remarkable increase in the enthalpy and in the free energy.
31953177	8	28	theme	protease	985:992	arg1	catalyst					994:1001	the immobilized protease catalyst	969:1001	the immobilized protease catalyst	969:1001	Moreover, the enzyme stability enhancement for the immobilized protease catalyst was accompanied with a remarkable increase in the enthalpy and in the free energy.
31953177	9	29	theme	Carr-PAMAM	1112:1121	arg1	beads					1127:1131	Carr-PAMAM gel beads	1112:1131	Carr-PAMAM gel beads	1112:1131	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	1	30	theme	groups	199:204	arg1	density					174:180	a high density	167:180	a high density of surface amino groups	167:204	Hyperbranched polyamidoamine (PAMAM) has a high density of surface amino groups.
31953177	9	31	from	film	1284:1287	arg1	removal					1250:1256	an effective removal	1237:1256	an effective removal of silver from used X-ray film by the immobilized protease	1237:1315	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	7	32	theme	immobilized	888:898	arg1	enzyme					900:905	free and immobilized enzyme	879:905	free and immobilized enzyme	879:905	Also, the D-values increased from 165.03 min to 548.23 min for free and immobilized enzyme, respectively.
31953177	8	33	theme	remarkable	1026:1035	arg1	increase					1037:1044	a remarkable increase	1024:1044	a remarkable increase in the enthalpy and in the free energy	1024:1083	Moreover, the enzyme stability enhancement for the immobilized protease catalyst was accompanied with a remarkable increase in the enthalpy and in the free energy.
31953177	6	34	theme	thermal	684:690	arg1	stability					692:700	the thermal stability	680:700	the thermal stability at high temperature for the immobilized protease	680:749	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	9	35	theme	initial	1155:1161	arg1	activity					1163:1170	its initial activity	1151:1170	its initial activity	1151:1170	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	7	36	dep	548.23 min	864:873	arg1	165.03 min					850:859	165.03 min	850:859	165.03 min	850:859	Also, the D-values increased from 165.03 min to 548.23 min for free and immobilized enzyme, respectively.
31953177	1	37	theme	Hyperbranched	126:138	arg1	PAMAM					156:160	PAMAM	156:160	PAMAM	156:160	Hyperbranched polyamidoamine (PAMAM) has a high density of surface amino groups.
31953177	1	37	theme	Hyperbranched	126:138	arg1	polyamidoamine					140:153	Hyperbranched polyamidoamine	126:153	Hyperbranched polyamidoamine (PAMAM)	126:161	Hyperbranched polyamidoamine (PAMAM) has a high density of surface amino groups.
31953177	6	38	from	time	782:785	arg1	stability					692:700	the thermal stability	680:700	the thermal stability at high temperature for the immobilized protease	680:749	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	6	38	from	time	782:785	arg1	temperature					710:720	high temperature	705:720	high temperature for the immobilized protease	705:749	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	9	39	from	4 °C.	1218:1222	arg1	8 weeks					1196:1202	8 weeks	1196:1202	8 weeks of storage at 4 °C.	1196:1222	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	9	39	from	4 °C.	1218:1222	arg1	storage					1207:1213	storage	1207:1213	storage at 4 °C.	1207:1222	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	2	40	theme	surface	241:247	arg1	modification					249:260	the surface modification	237:260	the surface modification of κ-carrageenan gel beads	237:287	This feature was exploited in the surface modification of κ-carrageenan gel beads for successful protease immobilization.
31953177	6	41	theme	half-life	772:780	arg1	time					782:785	increased half-life time	762:785	an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min	662:813	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	6	42	from	24.06 min	792:800	arg1	time					782:785	increased half-life time	762:785	an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min	662:813	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	6	42	from	24.06 min	792:800	arg1	enhancement					665:675	an enhancement	662:675	an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min	662:813	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	0	43	theme	protease	63:70	arg1	immobilization					72:85	protease immobilization	63:85	protease immobilization	63:85	Functionalized κ-carrageenan/hyperbranched poly(amidoamine)for protease immobilization: Thermodynamics and stability studies.
31953177	9	44	theme	repeated	1338:1345	arg1	cycles					1347:1352	six repeated cycles	1334:1352	six repeated cycles	1334:1352	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	6	45	from	enhancement	665:675	arg1	stability					692:700	the thermal stability	680:700	the thermal stability at high temperature for the immobilized protease	680:749	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	6	45	from	enhancement	665:675	arg1	temperature					710:720	high temperature	705:720	high temperature for the immobilized protease	705:749	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	6	46	theme	increased	762:770	arg1	time					782:785	increased half-life time	762:785	an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min	662:813	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	9	47	theme	X-ray	1278:1282	arg1	film					1284:1287	used X-ray film	1273:1287	used X-ray film by the immobilized protease	1273:1315	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	3	48	theme	optimum	333:339	arg1	pH					347:348	The optimum PAMAM pH	329:348	The optimum PAMAM pH	329:348	The optimum PAMAM pH was at 2.1 and 9.3.
31953177	4	49	theme	higher	423:428	arg1	pH					430:431	the higher pH	419:431	the higher pH	419:431	However, treatment of κ-carrageenan gel beads at the higher pH showed re-usability for more than seven successive times.
31953177	8	50	theme	stability	943:951	arg1	enhancement					953:963	the enzyme stability enhancement	932:963	the enzyme stability enhancement for the immobilized protease catalyst	932:1001	Moreover, the enzyme stability enhancement for the immobilized protease catalyst was accompanied with a remarkable increase in the enthalpy and in the free energy.
31953177	5	51	theme	maximum	549:555	arg1	yield					572:576	the maximum immobilization yield	545:576	the maximum immobilization yield	545:576	As a result of central composite design optimization, the maximum immobilization yield was obtained by soaking 8 U for 24 h.
31953177	5	51	theme	maximum	549:555	arg1	result					496:501	a result	494:501	a result of central composite design optimization	494:542	As a result of central composite design optimization, the maximum immobilization yield was obtained by soaking 8 U for 24 h.
31953177	9	52	theme	activity	1163:1170	arg1	%					1146:1146	89%	1144:1146	89% of its initial activity	1144:1170	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	9	52	theme	activity	1163:1170	arg1	activity					1163:1170	its initial activity	1151:1170	its initial activity	1151:1170	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	8	53	theme	immobilized	973:983	arg1	catalyst					994:1001	the immobilized protease catalyst	969:1001	the immobilized protease catalyst	969:1001	Moreover, the enzyme stability enhancement for the immobilized protease catalyst was accompanied with a remarkable increase in the enthalpy and in the free energy.
31953177	2	54	theme	gel	279:281	arg1	beads					283:287	κ-carrageenan gel beads	265:287	κ-carrageenan gel beads	265:287	This feature was exploited in the surface modification of κ-carrageenan gel beads for successful protease immobilization.
31953177	5	55	theme	immobilization	557:570	arg1	yield					572:576	the maximum immobilization yield	545:576	the maximum immobilization yield	545:576	As a result of central composite design optimization, the maximum immobilization yield was obtained by soaking 8 U for 24 h.
31953177	5	55	theme	immobilization	557:570	arg1	result					496:501	a result	494:501	a result of central composite design optimization	494:542	As a result of central composite design optimization, the maximum immobilization yield was obtained by soaking 8 U for 24 h.
31953177	6	56	theme	immobilized	730:740	arg1	protease					742:749	the immobilized protease	726:749	the immobilized protease	726:749	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	6	57	from	temperature	710:720	arg1	time					782:785	increased half-life time	762:785	an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min	662:813	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	6	57	from	temperature	710:720	arg1	stability					692:700	the thermal stability	680:700	the thermal stability at high temperature for the immobilized protease	680:749	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	6	57	from	temperature	710:720	arg1	enhancement					665:675	an enhancement	662:675	an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min	662:813	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
31953177	0	58	dep	poly	43:46	arg1	studies					117:123	Thermodynamics and stability studies	88:123	Functionalized κ-carrageenan/hyperbranched poly(amidoamine)for protease immobilization: Thermodynamics and stability studies.	0:124	Functionalized κ-carrageenan/hyperbranched poly(amidoamine)for protease immobilization: Thermodynamics and stability studies.
31953177	2	59	mod	modification	249:260	arg1	beads					283:287	κ-carrageenan gel beads	265:287	κ-carrageenan gel beads	265:287	This feature was exploited in the surface modification of κ-carrageenan gel beads for successful protease immobilization.
31953177	2	59	mod	modification	249:260	arg3	surface					241:247	the surface modification	237:260	the surface modification of κ-carrageenan gel beads	237:287	This feature was exploited in the surface modification of κ-carrageenan gel beads for successful protease immobilization.
31953177	9	60	theme	gel	1123:1125	arg1	beads					1127:1131	Carr-PAMAM gel beads	1112:1131	Carr-PAMAM gel beads	1112:1131	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	9	61	theme	immobilized	1296:1306	arg1	protease					1308:1315	the immobilized protease	1292:1315	the immobilized protease	1292:1315	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	5	62	theme	composite	514:522	arg1	optimization					531:542	central composite design optimization	506:542	central composite design optimization	506:542	As a result of central composite design optimization, the maximum immobilization yield was obtained by soaking 8 U for 24 h.
31953177	8	63	from	increase	1037:1044	arg1	enthalpy					1053:1060	the enthalpy	1049:1060	the enthalpy	1049:1060	Moreover, the enzyme stability enhancement for the immobilized protease catalyst was accompanied with a remarkable increase in the enthalpy and in the free energy.
31953177	8	63	from	increase	1037:1044	arg1	energy					1078:1083	the free energy	1069:1083	the free energy	1069:1083	Moreover, the enzyme stability enhancement for the immobilized protease catalyst was accompanied with a remarkable increase in the enthalpy and in the free energy.
31953177	9	64	theme	effective	1240:1248	arg1	removal					1250:1256	an effective removal	1237:1256	an effective removal of silver from used X-ray film by the immobilized protease	1237:1315	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	9	65	theme	silver	1261:1266	arg1	removal					1250:1256	an effective removal	1237:1256	an effective removal of silver from used X-ray film by the immobilized protease	1237:1315	Immobilized protease onto Carr-PAMAM gel beads can retain 89% of its initial activity and lost only 11% after 8 weeks of storage at 4 °C. Furthermore, an effective removal of silver from used X-ray film by the immobilized protease was achieved for six repeated cycles.
31953177	5	66	theme	design	524:529	arg1	optimization					531:542	central composite design optimization	506:542	central composite design optimization	506:542	As a result of central composite design optimization, the maximum immobilization yield was obtained by soaking 8 U for 24 h.
31953177	5	67	theme	central	506:512	arg1	optimization					531:542	central composite design optimization	506:542	central composite design optimization	506:542	As a result of central composite design optimization, the maximum immobilization yield was obtained by soaking 8 U for 24 h.
31953177	6	68	theme	thermodynamics	632:645	arg1	studies					647:653	The comparative thermodynamics studies	616:653	The comparative thermodynamics studies	616:653	The comparative thermodynamics studies showed an enhancement in the thermal stability at high temperature for the immobilized protease as well as increased half-life time from 24.06 min to 79.95 min.
34247138	8	0	theme	sensory	1408:1414	arg1	properties					1416:1425	The chemical, rheological and sensory properties	1378:1425	The chemical, rheological and sensory properties of the final produced yogurt	1378:1454	The chemical, rheological and sensory properties of the final produced yogurt were evaluated during storage periods up to 9 days at 5 °C.
34247138	0	1	theme	isolate	145:151	arg1	MK852178					166:173	the new isolate L. paracasei MK852178	137:173	the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people	137:233	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	9	2	theme	chemical	1722:1729	arg1	properties					1743:1752	the chemical and sensory properties	1718:1752	the chemical and sensory properties	1718:1752	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	0	3	theme	new	141:143	arg1	MK852178					166:173	the new isolate L. paracasei MK852178	137:173	the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people	137:233	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	7	4	theme	β-galactosidase	1153:1167	arg1	β-galactosidase					1153:1167	β-galactosidase	1153:1167	β-galactosidase	1153:1167	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	7	4	theme	β-galactosidase	1153:1167	arg1	%					1148:1148	0.3 or 0.6%	1138:1148	0.3 or 0.6% of β-galactosidase	1138:1167	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	1	5	theme	Converting	236:245	arg1	target					287:292	the main target	278:292	the main target for many kinds of research nowadays	278:328	Converting wastes to valuable products is the main target for many kinds of research nowadays.
34247138	1	5	theme	Converting	236:245	arg1	wastes					247:252	Converting wastes	236:252	Converting wastes to valuable products	236:273	Converting wastes to valuable products is the main target for many kinds of research nowadays.
34247138	0	6	theme	new	74:76	arg1	approach					78:85	A new approach	72:85	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.	0:234	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	1	7	theme	nowadays	321:328	arg1	kinds					303:307	many kinds	298:307	many kinds of research nowadays	298:328	Converting wastes to valuable products is the main target for many kinds of research nowadays.
34247138	0	8	theme	paracasei	156:164	arg1	MK852178					166:173	the new isolate L. paracasei MK852178	137:173	the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people	137:233	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	5	9	dep	series	816:821	arg1	identified					853:862	identified	853:862	identified using 16S ribosomal RNA gene partial sequence	853:908	It was produced by Lactobacillus paracasei, a series isolated from fermented milk, identified using 16S ribosomal RNA gene partial sequence and had the accession number MK852178.
34247138	5	9	dep	series	816:821	arg1	isolated					823:830	isolated	823:830	isolated from fermented milk	823:850	It was produced by Lactobacillus paracasei, a series isolated from fermented milk, identified using 16S ribosomal RNA gene partial sequence and had the accession number MK852178.
34247138	5	9	dep	series	816:821	arg1	had					914:916	had	914:916	had the accession number MK852178	914:946	It was produced by Lactobacillus paracasei, a series isolated from fermented milk, identified using 16S ribosomal RNA gene partial sequence and had the accession number MK852178.
34247138	3	10	theme	rice	516:519	arg1	constituents					562:573	the main medium constituents	546:573	the main medium constituents	546:573	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	3	10	theme	rice	516:519	arg1	straw					521:525	rice straw	516:525	rice straw	516:525	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	3	10	theme	rice	516:519	arg1	peel					538:541	orange peel	531:541	orange peel	531:541	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	8	11	theme	produced	1440:1447	arg1	yogurt					1449:1454	the final produced yogurt	1430:1454	the final produced yogurt	1430:1454	The chemical, rheological and sensory properties of the final produced yogurt were evaluated during storage periods up to 9 days at 5 °C.
34247138	0	12	theme	L.	153:154	arg1	MK852178					166:173	the new isolate L. paracasei MK852178	137:173	the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people	137:233	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	5	13	theme	accession	922:930	arg1	number					932:937	the accession number MK852178	918:946	the accession number MK852178	918:946	It was produced by Lactobacillus paracasei, a series isolated from fermented milk, identified using 16S ribosomal RNA gene partial sequence and had the accession number MK852178.
34247138	9	14	theme	lactose-intolerant	1633:1650	arg1	people					1652:1657	lactose-intolerant people	1633:1657	lactose-intolerant people	1633:1657	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	5	15	theme	gene	888:891	arg1	sequence					901:908	16S ribosomal RNA gene partial sequence	870:908	16S ribosomal RNA gene partial sequence	870:908	It was produced by Lactobacillus paracasei, a series isolated from fermented milk, identified using 16S ribosomal RNA gene partial sequence and had the accession number MK852178.
34247138	8	16	theme	final	1434:1438	arg1	yogurt					1449:1454	the final produced yogurt	1430:1454	the final produced yogurt	1430:1454	The chemical, rheological and sensory properties of the final produced yogurt were evaluated during storage periods up to 9 days at 5 °C.
34247138	9	17	theme	additive	1584:1591	arg1	β-galactosidase					1553:1567	L. paracasei MK852178 β-galactosidase	1531:1567	L. paracasei MK852178 β-galactosidase	1531:1567	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	9	17	theme	additive	1584:1591	arg1	yogurt					1622:1627	a promising additive in manufacturing low lactose yogurt	1572:1627	a promising additive in manufacturing low lactose yogurt for lactose-intolerant people	1572:1657	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	0	18	theme	lactose-intolerant	209:226	arg1	people					228:233	lactose-intolerant people	209:233	lactose-intolerant people	209:233	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	3	19	theme	β-galactosidase	494:508	arg1	production					460:469	production	460:469	production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents	460:573	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	7	20	from	differences	1285:1295	arg1	protein					1306:1312	total protein	1300:1312	total protein	1300:1312	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	7	20	from	differences	1285:1295	arg1	fat					1329:1331	fat	1329:1331	fat	1329:1331	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	7	20	from	differences	1285:1295	arg1	ash					1338:1340	ash	1338:1340	ash	1338:1340	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	7	20	from	differences	1285:1295	arg1	solids					1321:1326	total solids	1315:1326	total solids	1315:1326	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	2	21	theme	getting	377:383	arg1	rid					385:387	getting rid	377:387	getting rid of it	377:393	Wastes represent an environmental problem and getting rid of it is not easy and causes pollution.
34247138	9	22	from	yogurt	1622:1627	arg1	conclusion					1519:1528	conclusion	1519:1528	conclusion	1519:1528	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	7	23	theme	therapeutic	1234:1244	arg1	yogurt					1258:1263	nutritional and therapeutic low-lactose yogurt	1218:1263	nutritional and therapeutic low-lactose yogurt	1218:1263	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	8	24	theme	chemical	1382:1389	arg1	properties					1416:1425	The chemical, rheological and sensory properties	1378:1425	The chemical, rheological and sensory properties of the final produced yogurt	1378:1454	The chemical, rheological and sensory properties of the final produced yogurt were evaluated during storage periods up to 9 days at 5 °C.
34247138	6	25	dep	difference	1062:1071	arg1	times					1078:1082	times	1078:1082	times	1078:1082	Plackett-Burman (PB) and Central Composite (CCD) Designs optimized the production scoring 1.683(10)6 U/ml with a difference five times higher than the non-optimized medium.
34247138	0	26	theme	straw	5:9	arg1	wastes					27:32	Rice straw and orange peel wastes	0:32	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.	0:234	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	8	27	theme	yogurt	1449:1454	arg1	properties					1416:1425	The chemical, rheological and sensory properties	1378:1425	The chemical, rheological and sensory properties of the final produced yogurt	1378:1454	The chemical, rheological and sensory properties of the final produced yogurt were evaluated during storage periods up to 9 days at 5 °C.
34247138	0	28	theme	low-lactose	186:196	arg1	yogurt					198:203	low-lactose yogurt	186:203	low-lactose yogurt for lactose-intolerant people	186:233	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	9	29	from	manufacturing	1596:1608	arg1	additive					1584:1591	additive	1584:1591	additive	1584:1591	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	5	30	theme	partial	893:899	arg1	sequence					901:908	16S ribosomal RNA gene partial sequence	870:908	16S ribosomal RNA gene partial sequence	870:908	It was produced by Lactobacillus paracasei, a series isolated from fermented milk, identified using 16S ribosomal RNA gene partial sequence and had the accession number MK852178.
34247138	7	31	theme	good	1181:1184	arg1	addition					1126:1133	The addition	1122:1133	The addition of 0.3 or 0.6% of β-galactosidase	1122:1167	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	7	31	theme	good	1181:1184	arg1	fortification					1186:1198	a good fortification	1179:1198	a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments	1179:1375	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	7	32	theme	low-lactose	1246:1256	arg1	yogurt					1258:1263	nutritional and therapeutic low-lactose yogurt	1218:1263	nutritional and therapeutic low-lactose yogurt	1218:1263	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	0	33	theme	Rice	0:3	arg1	straw					5:9	Rice straw	0:9	Rice straw	0:9	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	1	34	theme	valuable	257:264	arg1	products					266:273	valuable products	257:273	valuable products	257:273	Converting wastes to valuable products is the main target for many kinds of research nowadays.
34247138	9	35	theme	L.	1531:1532	arg1	β-galactosidase					1553:1567	L. paracasei MK852178 β-galactosidase	1531:1567	L. paracasei MK852178 β-galactosidase	1531:1567	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	9	35	theme	L.	1531:1532	arg1	yogurt					1622:1627	a promising additive in manufacturing low lactose yogurt	1572:1627	a promising additive in manufacturing low lactose yogurt for lactose-intolerant people	1572:1657	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	2	36	theme	environmental	351:363	arg1	problem					365:371	an environmental problem	348:371	an environmental problem	348:371	Wastes represent an environmental problem and getting rid of it is not easy and causes pollution.
34247138	0	37	theme	orange	15:20	arg1	peel					22:25	orange peel	15:25	orange peel	15:25	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	9	38	theme	paracasei	1534:1542	arg1	β-galactosidase					1553:1567	L. paracasei MK852178 β-galactosidase	1531:1567	L. paracasei MK852178 β-galactosidase	1531:1567	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	9	38	theme	paracasei	1534:1542	arg1	yogurt					1622:1627	a promising additive in manufacturing low lactose yogurt	1572:1627	a promising additive in manufacturing low lactose yogurt for lactose-intolerant people	1572:1657	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	9	39	theme	lactose	1614:1620	arg1	β-galactosidase					1553:1567	L. paracasei MK852178 β-galactosidase	1531:1567	L. paracasei MK852178 β-galactosidase	1531:1567	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	9	39	theme	lactose	1614:1620	arg1	yogurt					1622:1627	a promising additive in manufacturing low lactose yogurt	1572:1627	a promising additive in manufacturing low lactose yogurt for lactose-intolerant people	1572:1657	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	9	40	theme	sensory	1735:1741	arg1	properties					1743:1752	the chemical and sensory properties	1718:1752	the chemical and sensory properties	1718:1752	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	6	41	theme	five	1073:1076	arg1	times					1078:1082	times	1078:1082	times	1078:1082	Plackett-Burman (PB) and Central Composite (CCD) Designs optimized the production scoring 1.683(10)6 U/ml with a difference five times higher than the non-optimized medium.
34247138	7	42	theme	total	1315:1319	arg1	solids					1321:1326	total solids	1315:1326	total solids	1315:1326	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	9	43	from	additive	1584:1591	arg1	manufacturing					1596:1608	manufacturing	1596:1608	manufacturing	1596:1608	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	0	44	theme	β-galactosidase	90:104	arg1	production					123:132	β-galactosidase (lactase) enzyme production	90:132	β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people	90:233	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	3	45	theme	orange	531:536	arg1	straw					521:525	rice straw	516:525	rice straw	516:525	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	3	45	theme	orange	531:536	arg1	constituents					562:573	the main medium constituents	546:573	the main medium constituents	546:573	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	3	45	theme	orange	531:536	arg1	peel					538:541	orange peel	531:541	orange peel	531:541	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	2	46	theme	it	392:393	arg1	rid					385:387	getting rid	377:387	getting rid of it	377:393	Wastes represent an environmental problem and getting rid of it is not easy and causes pollution.
34247138	8	47	theme	storage	1478:1484	arg1	periods					1486:1492	storage periods	1478:1492	storage periods up to 9 days at 5 °C	1478:1513	The chemical, rheological and sensory properties of the final produced yogurt were evaluated during storage periods up to 9 days at 5 °C.
34247138	9	48	theme	low	1610:1612	arg1	β-galactosidase					1553:1567	L. paracasei MK852178 β-galactosidase	1531:1567	L. paracasei MK852178 β-galactosidase	1531:1567	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	9	48	theme	low	1610:1612	arg1	yogurt					1622:1627	a promising additive in manufacturing low lactose yogurt	1572:1627	a promising additive in manufacturing low lactose yogurt for lactose-intolerant people	1572:1657	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	8	49	dep	9 days	1500:1505	arg1	up					1494:1495	up	1494:1495	up	1494:1495	The chemical, rheological and sensory properties of the final produced yogurt were evaluated during storage periods up to 9 days at 5 °C.
34247138	3	50	theme	medium	555:560	arg1	straw					521:525	rice straw	516:525	rice straw	516:525	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	3	50	theme	medium	555:560	arg1	constituents					562:573	the main medium constituents	546:573	the main medium constituents	546:573	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	3	50	theme	medium	555:560	arg1	peel					538:541	orange peel	531:541	orange peel	531:541	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	4	51	theme	simple	644:649	arg1	galactose					624:632	galactose	624:632	galactose	624:632	β-galactosidase converts lactose to glucose and galactose which are simple sugars and can be fermented easily by lactose-intolerant people who represent more than 50% of the world's population.
34247138	4	51	theme	simple	644:649	arg1	glucose					612:618	glucose	612:618	glucose	612:618	β-galactosidase converts lactose to glucose and galactose which are simple sugars and can be fermented easily by lactose-intolerant people who represent more than 50% of the world's population.
34247138	4	51	theme	simple	644:649	arg1	sugars					651:656	simple sugars	644:656	simple sugars	644:656	β-galactosidase converts lactose to glucose and galactose which are simple sugars and can be fermented easily by lactose-intolerant people who represent more than 50% of the world's population.
34247138	0	52	theme	peel	22:25	arg1	wastes					27:32	Rice straw and orange peel wastes	0:32	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.	0:234	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	1	53	theme	main	282:285	arg1	target					287:292	the main target	278:292	the main target for many kinds of research nowadays	278:328	Converting wastes to valuable products is the main target for many kinds of research nowadays.
34247138	1	53	theme	main	282:285	arg1	wastes					247:252	Converting wastes	236:252	Converting wastes to valuable products	236:273	Converting wastes to valuable products is the main target for many kinds of research nowadays.
34247138	0	54	theme	lactase	107:113	arg1	production					123:132	β-galactosidase (lactase) enzyme production	90:132	β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people	90:233	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	6	55	dep	times	1078:1082	arg1	higher					1084:1089	higher	1084:1089	higher	1084:1089	Plackett-Burman (PB) and Central Composite (CCD) Designs optimized the production scoring 1.683(10)6 U/ml with a difference five times higher than the non-optimized medium.
34247138	7	56	theme	nutritional	1218:1228	arg1	yogurt					1258:1263	nutritional and therapeutic low-lactose yogurt	1218:1263	nutritional and therapeutic low-lactose yogurt	1218:1263	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	0	57	theme	cheap	37:41	arg1	substrates					60:69	cheap and eco-friendly substrates	37:69	cheap and eco-friendly substrates	37:69	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	9	58	theme	lactose	1680:1686	arg1	content					1688:1694	the lactose content	1676:1694	the lactose content	1676:1694	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	0	59	dep	wastes	27:32	arg1	approach					78:85	A new approach	72:85	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.	0:234	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	5	60	theme	16S	870:872	arg1	RNA					884:886	16S ribosomal RNA	870:886	16S ribosomal RNA gene partial sequence	870:908	It was produced by Lactobacillus paracasei, a series isolated from fermented milk, identified using 16S ribosomal RNA gene partial sequence and had the accession number MK852178.
34247138	8	61	from	5 °C	1510:1513	arg1	9 days					1500:1505	9 days	1500:1505	9 days at 5 °C	1500:1513	The chemical, rheological and sensory properties of the final produced yogurt were evaluated during storage periods up to 9 days at 5 °C.
34247138	6	62	theme	non-optimized	1100:1112	arg1	medium					1114:1119	the non-optimized medium	1096:1119	the non-optimized medium	1096:1119	Plackett-Burman (PB) and Central Composite (CCD) Designs optimized the production scoring 1.683(10)6 U/ml with a difference five times higher than the non-optimized medium.
34247138	0	63	theme	enzyme	116:121	arg1	production					123:132	β-galactosidase (lactase) enzyme production	90:132	β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people	90:233	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	3	64	theme	main	550:553	arg1	straw					521:525	rice straw	516:525	rice straw	516:525	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	3	64	theme	main	550:553	arg1	constituents					562:573	the main medium constituents	546:573	the main medium constituents	546:573	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	3	64	theme	main	550:553	arg1	peel					538:541	orange peel	531:541	orange peel	531:541	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	9	65	theme	promising	1574:1582	arg1	β-galactosidase					1553:1567	L. paracasei MK852178 β-galactosidase	1531:1567	L. paracasei MK852178 β-galactosidase	1531:1567	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	9	65	theme	promising	1574:1582	arg1	yogurt					1622:1627	a promising additive in manufacturing low lactose yogurt	1572:1627	a promising additive in manufacturing low lactose yogurt for lactose-intolerant people	1572:1657	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	5	66	theme	ribosomal	874:882	arg1	RNA					884:886	16S ribosomal RNA	870:886	16S ribosomal RNA gene partial sequence	870:908	It was produced by Lactobacillus paracasei, a series isolated from fermented milk, identified using 16S ribosomal RNA gene partial sequence and had the accession number MK852178.
34247138	1	67	theme	many	298:301	arg1	kinds					303:307	many kinds	298:307	many kinds of research nowadays	298:328	Converting wastes to valuable products is the main target for many kinds of research nowadays.
34247138	0	68	from	approach	78:85	arg1	production					123:132	β-galactosidase (lactase) enzyme production	90:132	β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people	90:233	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	9	69	theme	MK852178	1544:1551	arg1	β-galactosidase					1553:1567	L. paracasei MK852178 β-galactosidase	1531:1567	L. paracasei MK852178 β-galactosidase	1531:1567	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	9	69	theme	MK852178	1544:1551	arg1	yogurt					1622:1627	a promising additive in manufacturing low lactose yogurt	1572:1627	a promising additive in manufacturing low lactose yogurt for lactose-intolerant people	1572:1657	In conclusion, L. paracasei MK852178 β-galactosidase is a promising additive in manufacturing low lactose yogurt for lactose-intolerant people since it reduces the lactose content and doesn't influence the chemical and sensory properties.
34247138	5	70	theme	RNA	884:886	arg1	sequence					901:908	16S ribosomal RNA gene partial sequence	870:908	16S ribosomal RNA gene partial sequence	870:908	It was produced by Lactobacillus paracasei, a series isolated from fermented milk, identified using 16S ribosomal RNA gene partial sequence and had the accession number MK852178.
34247138	5	71	theme	fermented	837:845	arg1	milk					847:850	fermented milk	837:850	fermented milk	837:850	It was produced by Lactobacillus paracasei, a series isolated from fermented milk, identified using 16S ribosomal RNA gene partial sequence and had the accession number MK852178.
34247138	7	72	theme	total	1300:1304	arg1	protein					1306:1312	total protein	1300:1312	total protein	1300:1312	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	4	73	theme	lactose-intolerant	689:706	arg1	people					708:713	lactose-intolerant people	689:713	lactose-intolerant people who represent more than 50% of the world's population	689:767	β-galactosidase converts lactose to glucose and galactose which are simple sugars and can be fermented easily by lactose-intolerant people who represent more than 50% of the world's population.
34247138	0	74	theme	eco-friendly	47:58	arg1	substrates					60:69	cheap and eco-friendly substrates	37:69	cheap and eco-friendly substrates	37:69	Rice straw and orange peel wastes as cheap and eco-friendly substrates: A new approach in β-galactosidase (lactase) enzyme production by the new isolate L. paracasei MK852178 to produce low-lactose yogurt for lactose-intolerant people.
34247138	8	75	theme	rheological	1392:1402	arg1	properties					1416:1425	The chemical, rheological and sensory properties	1378:1425	The chemical, rheological and sensory properties of the final produced yogurt	1378:1454	The chemical, rheological and sensory properties of the final produced yogurt were evaluated during storage periods up to 9 days at 5 °C.
34247138	7	76	theme	significant	1273:1283	arg1	differences					1285:1295	no significant differences	1270:1295	no significant differences in total protein, total solids, fat, and ash between control and all treatments	1270:1375	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	3	77	theme	valuable	478:485	arg1	β-galactosidase					494:508	the valuable enzyme β-galactosidase	474:508	the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents	474:573	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
34247138	7	78	theme	%	1148:1148	arg1	addition					1126:1133	The addition	1122:1133	The addition of 0.3 or 0.6% of β-galactosidase	1122:1167	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	7	78	theme	%	1148:1148	arg1	fortification					1186:1198	a good fortification	1179:1198	a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments	1179:1375	The addition of 0.3 or 0.6% of β-galactosidase serves as a good fortification for manufacturing nutritional and therapeutic low-lactose yogurt with no significant differences in total protein, total solids, fat, and ash between control and all treatments.
34247138	6	79	dep	Plackett-Burman	949:963	arg1	Designs					998:1004	Designs	998:1004	Designs	998:1004	Plackett-Burman (PB) and Central Composite (CCD) Designs optimized the production scoring 1.683(10)6 U/ml with a difference five times higher than the non-optimized medium.
34247138	4	80	theme	population	758:767	arg1	population					758:767	the world's population	746:767	the world's population	746:767	β-galactosidase converts lactose to glucose and galactose which are simple sugars and can be fermented easily by lactose-intolerant people who represent more than 50% of the world's population.
34247138	4	80	theme	population	758:767	arg1	%					741:741	more than 50%	729:741	more than 50% of the world's population	729:767	β-galactosidase converts lactose to glucose and galactose which are simple sugars and can be fermented easily by lactose-intolerant people who represent more than 50% of the world's population.
34247138	3	81	theme	enzyme	487:492	arg1	β-galactosidase					494:508	the valuable enzyme β-galactosidase	474:508	the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents	474:573	Accordingly, this study offers production of the valuable enzyme β-galactosidase using rice straw and orange peel as the main medium constituents.
33925509	4	0	theme	UDP-glucose	733:743	arg1	production					697:706	Increased production	687:706	Increased production of the capsule precursor UDP-glucose	687:743	Increased production of the capsule precursor UDP-glucose has been identified by 31P-NMR in CDM with glucose.
33925509	6	1	from	serotype	1143:1150	arg1	events					1131:1136	two different events	1117:1136	two different events from serotype 6A	1117:1153	Whole-genome sequencing analyses of serotype 6F isolates suggested that the isolates evolved during two different events from serotype 6A during the time when the 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced.
33925509	2	2	theme	structure	406:414	arg1	composition					372:382	the environment-dependent composition	346:382	the environment-dependent composition of the polysaccharide structure of S. pneumoniae serotype 6F	346:443	Here, we investigated the environment-dependent composition of the polysaccharide structure of S. pneumoniae serotype 6F.
33925509	1	3	theme	unequivocal	267:277	arg1	identification					279:292	the unequivocal identification	263:292	the unequivocal identification of the pneumococcal serotype	263:321	The structure of the exopolysaccharide capsule of Streptococcus pneumoniae is defined by the genetic arrangement of the capsule operon allowing the unequivocal identification of the pneumococcal serotype.
33925509	0	4	theme	Polysaccharide	86:99	arg1	Structure					39:47	the Structure	35:47	the Structure of Streptococcus pneumoniae Capsular Polysaccharide	35:99	Carbon Source-Dependent Changes of the Structure of Streptococcus pneumoniae Capsular Polysaccharide with Serotype 6F.
33925509	8	5	theme	invasive	1548:1555	arg1	blood					1579:1583	the blood	1575:1583	the blood (glucose rich)	1575:1598	Therefore, 6F strains may show slightly different polysaccharide composition while colonizing the human nasopharynx (galactose rich) as compared to invasive locations such as the blood (glucose rich).
33925509	8	5	theme	invasive	1548:1555	arg1	locations					1557:1565	invasive locations	1548:1565	invasive locations such as the blood (glucose rich)	1548:1598	Therefore, 6F strains may show slightly different polysaccharide composition while colonizing the human nasopharynx (galactose rich) as compared to invasive locations such as the blood (glucose rich).
33925509	2	6	theme	polysaccharide	391:404	arg1	structure					406:414	the polysaccharide structure	387:414	the polysaccharide structure of S. pneumoniae serotype 6F	387:443	Here, we investigated the environment-dependent composition of the polysaccharide structure of S. pneumoniae serotype 6F.
33925509	6	7	theme	sequencing	1030:1039	arg1	analyses					1041:1048	Whole-genome sequencing analyses	1017:1048	Whole-genome sequencing analyses of serotype 6F isolates	1017:1072	Whole-genome sequencing analyses of serotype 6F isolates suggested that the isolates evolved during two different events from serotype 6A during the time when the 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced.
33925509	7	8	from	differences	1278:1288	arg1	structure					1306:1314	the capsular structure	1293:1314	the capsular structure of serotype 6F strains using glucose as compared to galactose as the carbon source	1293:1397	In conclusion, this study shows differences in the capsular structure of serotype 6F strains using glucose as compared to galactose as the carbon source.
33925509	3	9	theme	strains	574:580	arg1	capsule					547:553	the exopolysaccharide capsule	525:553	the exopolysaccharide capsule of the serotype 6F strains	525:580	When grown in a chemically defined medium (CDM) with glucose versus galactose, the exopolysaccharide capsule of the serotype 6F strains reveals a ratio of 1/0.6 or 1/0.3 for galactose/glucose in the capsule by 1H-NMR analyses, respectively.
33925509	6	10	theme	Whole-genome	1017:1028	arg1	analyses					1041:1048	Whole-genome sequencing analyses	1017:1048	Whole-genome sequencing analyses of serotype 6F isolates	1017:1072	Whole-genome sequencing analyses of serotype 6F isolates suggested that the isolates evolved during two different events from serotype 6A during the time when the 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced.
33925509	0	11	theme	Serotype	106:113	arg1	6F					115:116	Serotype 6F	106:116	Serotype 6F	106:116	Carbon Source-Dependent Changes of the Structure of Streptococcus pneumoniae Capsular Polysaccharide with Serotype 6F.
33925509	5	12	theme	decreased	860:868	arg1	labelling					870:878	decreased labelling	860:878	decreased labelling of Hyp6AG4 (specific for serotype 6A) antibodies	860:927	Flow cytometric experiments using monoclonal antibodies showed decreased labelling of Hyp6AG4 (specific for serotype 6A) antibodies when 6F is grown in glucose as compared to galactose, which mirrors the 1H-NMR results.
33925509	3	13	theme	exopolysaccharide	529:545	arg1	capsule					547:553	the exopolysaccharide capsule	525:553	the exopolysaccharide capsule of the serotype 6F strains	525:580	When grown in a chemically defined medium (CDM) with glucose versus galactose, the exopolysaccharide capsule of the serotype 6F strains reveals a ratio of 1/0.6 or 1/0.3 for galactose/glucose in the capsule by 1H-NMR analyses, respectively.
33925509	2	14	theme	environment-dependent	350:370	arg1	composition					372:382	the environment-dependent composition	346:382	the environment-dependent composition of the polysaccharide structure of S. pneumoniae serotype 6F	346:443	Here, we investigated the environment-dependent composition of the polysaccharide structure of S. pneumoniae serotype 6F.
33925509	4	15	theme	precursor	723:731	arg1	UDP-glucose					733:743	the capsule precursor UDP-glucose	711:743	the capsule precursor UDP-glucose	711:743	Increased production of the capsule precursor UDP-glucose has been identified by 31P-NMR in CDM with glucose.
33925509	6	16	theme	different	1121:1129	arg1	events					1131:1136	two different events	1117:1136	two different events from serotype 6A	1117:1153	Whole-genome sequencing analyses of serotype 6F isolates suggested that the isolates evolved during two different events from serotype 6A during the time when the 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced.
33925509	3	17	theme	serotype	562:569	arg1	strains					574:580	the serotype 6F strains	558:580	the serotype 6F strains	558:580	When grown in a chemically defined medium (CDM) with glucose versus galactose, the exopolysaccharide capsule of the serotype 6F strains reveals a ratio of 1/0.6 or 1/0.3 for galactose/glucose in the capsule by 1H-NMR analyses, respectively.
33925509	4	18	theme	Increased	687:695	arg1	production					697:706	Increased production	687:706	Increased production of the capsule precursor UDP-glucose	687:743	Increased production of the capsule precursor UDP-glucose has been identified by 31P-NMR in CDM with glucose.
33925509	3	19	theme	6F	571:572	arg1	strains					574:580	the serotype 6F strains	558:580	the serotype 6F strains	558:580	When grown in a chemically defined medium (CDM) with glucose versus galactose, the exopolysaccharide capsule of the serotype 6F strains reveals a ratio of 1/0.6 or 1/0.3 for galactose/glucose in the capsule by 1H-NMR analyses, respectively.
33925509	2	20	theme	6F	442:443	arg1	structure					406:414	the polysaccharide structure	387:414	the polysaccharide structure of S. pneumoniae serotype 6F	387:443	Here, we investigated the environment-dependent composition of the polysaccharide structure of S. pneumoniae serotype 6F.
33925509	0	21	theme	Source-Dependent	7:22	arg1	Changes					24:30	Carbon Source-Dependent Changes	0:30	Carbon Source-Dependent Changes of the Structure of Streptococcus pneumoniae Capsular Polysaccharide with Serotype 6F.	0:117	Carbon Source-Dependent Changes of the Structure of Streptococcus pneumoniae Capsular Polysaccharide with Serotype 6F.
33925509	5	22	theme	cytometric	802:811	arg1	experiments					813:823	Flow cytometric experiments	797:823	Flow cytometric experiments using monoclonal antibodies	797:851	Flow cytometric experiments using monoclonal antibodies showed decreased labelling of Hyp6AG4 (specific for serotype 6A) antibodies when 6F is grown in glucose as compared to galactose, which mirrors the 1H-NMR results.
33925509	6	23	theme	conjugate	1203:1211	arg1	PCV-13					1222:1227	PCV-13	1222:1227	PCV-13	1222:1227	Whole-genome sequencing analyses of serotype 6F isolates suggested that the isolates evolved during two different events from serotype 6A during the time when the 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced.
33925509	6	23	theme	conjugate	1203:1211	arg1	vaccine					1213:1219	the 13-valent pneumococcal conjugate vaccine	1176:1219	the 13-valent pneumococcal conjugate vaccine (PCV-13)	1176:1228	Whole-genome sequencing analyses of serotype 6F isolates suggested that the isolates evolved during two different events from serotype 6A during the time when the 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced.
33925509	2	24	theme	serotype	433:440	arg1	6F					442:443	S. pneumoniae serotype 6F	419:443	S. pneumoniae serotype 6F	419:443	Here, we investigated the environment-dependent composition of the polysaccharide structure of S. pneumoniae serotype 6F.
33925509	0	25	theme	Carbon	0:5	arg1	Changes					24:30	Carbon Source-Dependent Changes	0:30	Carbon Source-Dependent Changes of the Structure of Streptococcus pneumoniae Capsular Polysaccharide with Serotype 6F.	0:117	Carbon Source-Dependent Changes of the Structure of Streptococcus pneumoniae Capsular Polysaccharide with Serotype 6F.
33925509	1	26	theme	pneumococcal	301:312	arg1	serotype					314:321	the pneumococcal serotype	297:321	the pneumococcal serotype	297:321	The structure of the exopolysaccharide capsule of Streptococcus pneumoniae is defined by the genetic arrangement of the capsule operon allowing the unequivocal identification of the pneumococcal serotype.
33925509	3	27	theme	1/0.6	601:605	arg1	ratio					592:596	a ratio	590:596	a ratio of 1/0.6 or 1/0.3 for galactose/glucose	590:636	When grown in a chemically defined medium (CDM) with glucose versus galactose, the exopolysaccharide capsule of the serotype 6F strains reveals a ratio of 1/0.6 or 1/0.3 for galactose/glucose in the capsule by 1H-NMR analyses, respectively.
33925509	2	28	theme	pneumoniae	422:431	arg1	6F					442:443	S. pneumoniae serotype 6F	419:443	S. pneumoniae serotype 6F	419:443	Here, we investigated the environment-dependent composition of the polysaccharide structure of S. pneumoniae serotype 6F.
33925509	1	29	theme	serotype	314:321	arg1	identification					279:292	the unequivocal identification	263:292	the unequivocal identification of the pneumococcal serotype	263:321	The structure of the exopolysaccharide capsule of Streptococcus pneumoniae is defined by the genetic arrangement of the capsule operon allowing the unequivocal identification of the pneumococcal serotype.
33925509	6	30	theme	13-valent	1180:1188	arg1	PCV-13					1222:1227	PCV-13	1222:1227	PCV-13	1222:1227	Whole-genome sequencing analyses of serotype 6F isolates suggested that the isolates evolved during two different events from serotype 6A during the time when the 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced.
33925509	6	30	theme	13-valent	1180:1188	arg1	vaccine					1213:1219	the 13-valent pneumococcal conjugate vaccine	1176:1219	the 13-valent pneumococcal conjugate vaccine (PCV-13)	1176:1228	Whole-genome sequencing analyses of serotype 6F isolates suggested that the isolates evolved during two different events from serotype 6A during the time when the 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced.
33925509	1	31	theme	genetic	212:218	arg1	arrangement					220:230	the genetic arrangement	208:230	the genetic arrangement of the capsule operon allowing the unequivocal identification of the pneumococcal serotype	208:321	The structure of the exopolysaccharide capsule of Streptococcus pneumoniae is defined by the genetic arrangement of the capsule operon allowing the unequivocal identification of the pneumococcal serotype.
33925509	6	32	theme	pneumococcal	1190:1201	arg1	PCV-13					1222:1227	PCV-13	1222:1227	PCV-13	1222:1227	Whole-genome sequencing analyses of serotype 6F isolates suggested that the isolates evolved during two different events from serotype 6A during the time when the 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced.
33925509	6	32	theme	pneumococcal	1190:1201	arg1	vaccine					1213:1219	the 13-valent pneumococcal conjugate vaccine	1176:1219	the 13-valent pneumococcal conjugate vaccine (PCV-13)	1176:1228	Whole-genome sequencing analyses of serotype 6F isolates suggested that the isolates evolved during two different events from serotype 6A during the time when the 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced.
33925509	8	33	theme	rich	1594:1597	arg1	blood					1579:1583	the blood	1575:1583	the blood (glucose rich)	1575:1598	Therefore, 6F strains may show slightly different polysaccharide composition while colonizing the human nasopharynx (galactose rich) as compared to invasive locations such as the blood (glucose rich).
33925509	5	34	theme	1H-NMR	1001:1006	arg1	results					1008:1014	the 1H-NMR results	997:1014	the 1H-NMR results	997:1014	Flow cytometric experiments using monoclonal antibodies showed decreased labelling of Hyp6AG4 (specific for serotype 6A) antibodies when 6F is grown in glucose as compared to galactose, which mirrors the 1H-NMR results.
33925509	1	35	theme	pneumoniae	183:192	arg1	capsule					158:164	the exopolysaccharide capsule	136:164	the exopolysaccharide capsule of Streptococcus pneumoniae	136:192	The structure of the exopolysaccharide capsule of Streptococcus pneumoniae is defined by the genetic arrangement of the capsule operon allowing the unequivocal identification of the pneumococcal serotype.
33925509	1	36	theme	capsule	158:164	arg1	structure					123:131	The structure	119:131	The structure of the exopolysaccharide capsule of Streptococcus pneumoniae	119:192	The structure of the exopolysaccharide capsule of Streptococcus pneumoniae is defined by the genetic arrangement of the capsule operon allowing the unequivocal identification of the pneumococcal serotype.
33925509	0	37	theme	Structure	39:47	arg1	Changes					24:30	Carbon Source-Dependent Changes	0:30	Carbon Source-Dependent Changes of the Structure of Streptococcus pneumoniae Capsular Polysaccharide with Serotype 6F.	0:117	Carbon Source-Dependent Changes of the Structure of Streptococcus pneumoniae Capsular Polysaccharide with Serotype 6F.
33925509	0	38	dep	Streptococcus	52:64	arg1	pneumoniae					66:75	pneumoniae	66:75	pneumoniae	66:75	Carbon Source-Dependent Changes of the Structure of Streptococcus pneumoniae Capsular Polysaccharide with Serotype 6F.
33925509	3	39	theme	defined	473:479	arg1	medium					481:486	a chemically defined medium	460:486	a chemically defined medium (CDM) with glucose versus galactose	460:522	When grown in a chemically defined medium (CDM) with glucose versus galactose, the exopolysaccharide capsule of the serotype 6F strains reveals a ratio of 1/0.6 or 1/0.3 for galactose/glucose in the capsule by 1H-NMR analyses, respectively.
33925509	3	39	theme	defined	473:479	arg1	CDM					489:491	CDM	489:491	CDM	489:491	When grown in a chemically defined medium (CDM) with glucose versus galactose, the exopolysaccharide capsule of the serotype 6F strains reveals a ratio of 1/0.6 or 1/0.3 for galactose/glucose in the capsule by 1H-NMR analyses, respectively.
33925509	7	40	theme	6F	1328:1329	arg1	strains					1331:1337	serotype 6F strains	1319:1337	serotype 6F strains using glucose as compared to galactose as the carbon source	1319:1397	In conclusion, this study shows differences in the capsular structure of serotype 6F strains using glucose as compared to galactose as the carbon source.
33925509	4	41	theme	capsule	715:721	arg1	UDP-glucose					733:743	the capsule precursor UDP-glucose	711:743	the capsule precursor UDP-glucose	711:743	Increased production of the capsule precursor UDP-glucose has been identified by 31P-NMR in CDM with glucose.
33925509	8	42	dep	nasopharynx	1504:1514	arg1	rich					1527:1530	rich	1527:1530	rich	1527:1530	Therefore, 6F strains may show slightly different polysaccharide composition while colonizing the human nasopharynx (galactose rich) as compared to invasive locations such as the blood (glucose rich).
33925509	8	42	dep	nasopharynx	1504:1514	arg1	compared					1536:1543	compared	1536:1543	compared to invasive locations such as the blood (glucose rich)	1536:1598	Therefore, 6F strains may show slightly different polysaccharide composition while colonizing the human nasopharynx (galactose rich) as compared to invasive locations such as the blood (glucose rich).
33925509	3	43	theme	1H-NMR	656:661	arg1	analyses					663:670	1H-NMR analyses	656:670	1H-NMR analyses	656:670	When grown in a chemically defined medium (CDM) with glucose versus galactose, the exopolysaccharide capsule of the serotype 6F strains reveals a ratio of 1/0.6 or 1/0.3 for galactose/glucose in the capsule by 1H-NMR analyses, respectively.
33925509	7	44	theme	strains	1331:1337	arg1	structure					1306:1314	the capsular structure	1293:1314	the capsular structure of serotype 6F strains using glucose as compared to galactose as the carbon source	1293:1397	In conclusion, this study shows differences in the capsular structure of serotype 6F strains using glucose as compared to galactose as the carbon source.
33925509	0	45	theme	Streptococcus	52:64	arg1	Polysaccharide					86:99	Streptococcus pneumoniae Capsular Polysaccharide	52:99	Streptococcus pneumoniae Capsular Polysaccharide	52:99	Carbon Source-Dependent Changes of the Structure of Streptococcus pneumoniae Capsular Polysaccharide with Serotype 6F.
33925509	4	46	with	CDM	779:781	arg1	glucose					788:794	glucose	788:794	glucose	788:794	Increased production of the capsule precursor UDP-glucose has been identified by 31P-NMR in CDM with glucose.
33925509	8	47	theme	human	1498:1502	arg1	nasopharynx					1504:1514	the human nasopharynx	1494:1514	the human nasopharynx (galactose rich) as compared to invasive locations such as the blood (glucose rich)	1494:1598	Therefore, 6F strains may show slightly different polysaccharide composition while colonizing the human nasopharynx (galactose rich) as compared to invasive locations such as the blood (glucose rich).
33925509	0	48	with	Changes	24:30	arg1	6F					115:116	Serotype 6F	106:116	Serotype 6F	106:116	Carbon Source-Dependent Changes of the Structure of Streptococcus pneumoniae Capsular Polysaccharide with Serotype 6F.
33925509	3	49	theme	1/0.3	610:614	arg1	ratio					592:596	a ratio	590:596	a ratio of 1/0.6 or 1/0.3 for galactose/glucose	590:636	When grown in a chemically defined medium (CDM) with glucose versus galactose, the exopolysaccharide capsule of the serotype 6F strains reveals a ratio of 1/0.6 or 1/0.3 for galactose/glucose in the capsule by 1H-NMR analyses, respectively.
33925509	7	50	theme	serotype	1319:1326	arg1	strains					1331:1337	serotype 6F strains	1319:1337	serotype 6F strains using glucose as compared to galactose as the carbon source	1319:1397	In conclusion, this study shows differences in the capsular structure of serotype 6F strains using glucose as compared to galactose as the carbon source.
33925509	3	51	with	medium	481:486	arg1	galactose					514:522	galactose	514:522	galactose	514:522	When grown in a chemically defined medium (CDM) with glucose versus galactose, the exopolysaccharide capsule of the serotype 6F strains reveals a ratio of 1/0.6 or 1/0.3 for galactose/glucose in the capsule by 1H-NMR analyses, respectively.
33925509	3	51	with	medium	481:486	arg1	glucose					499:505	glucose	499:505	glucose	499:505	When grown in a chemically defined medium (CDM) with glucose versus galactose, the exopolysaccharide capsule of the serotype 6F strains reveals a ratio of 1/0.6 or 1/0.3 for galactose/glucose in the capsule by 1H-NMR analyses, respectively.
33925509	8	52	theme	polysaccharide	1450:1463	arg1	composition					1465:1475	slightly different polysaccharide composition	1431:1475	slightly different polysaccharide composition	1431:1475	Therefore, 6F strains may show slightly different polysaccharide composition while colonizing the human nasopharynx (galactose rich) as compared to invasive locations such as the blood (glucose rich).
33925509	7	53	theme	carbon	1385:1390	arg1	source					1392:1397	the carbon source	1381:1397	the carbon source	1381:1397	In conclusion, this study shows differences in the capsular structure of serotype 6F strains using glucose as compared to galactose as the carbon source.
33925509	6	54	theme	6F	1062:1063	arg1	isolates					1065:1072	serotype 6F isolates	1053:1072	serotype 6F isolates	1053:1072	Whole-genome sequencing analyses of serotype 6F isolates suggested that the isolates evolved during two different events from serotype 6A during the time when the 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced.
33925509	7	55	theme	capsular	1297:1304	arg1	structure					1306:1314	the capsular structure	1293:1314	the capsular structure of serotype 6F strains using glucose as compared to galactose as the carbon source	1293:1397	In conclusion, this study shows differences in the capsular structure of serotype 6F strains using glucose as compared to galactose as the carbon source.
33925509	5	56	theme	antibodies	918:927	arg1	labelling					870:878	decreased labelling	860:878	decreased labelling of Hyp6AG4 (specific for serotype 6A) antibodies	860:927	Flow cytometric experiments using monoclonal antibodies showed decreased labelling of Hyp6AG4 (specific for serotype 6A) antibodies when 6F is grown in glucose as compared to galactose, which mirrors the 1H-NMR results.
33925509	1	57	theme	capsule	239:245	arg1	operon					247:252	the capsule operon	235:252	the capsule operon allowing the unequivocal identification of the pneumococcal serotype	235:321	The structure of the exopolysaccharide capsule of Streptococcus pneumoniae is defined by the genetic arrangement of the capsule operon allowing the unequivocal identification of the pneumococcal serotype.
33925509	8	58	theme	different	1440:1448	arg1	composition					1465:1475	slightly different polysaccharide composition	1431:1475	slightly different polysaccharide composition	1431:1475	Therefore, 6F strains may show slightly different polysaccharide composition while colonizing the human nasopharynx (galactose rich) as compared to invasive locations such as the blood (glucose rich).
33925509	1	59	theme	exopolysaccharide	140:156	arg1	capsule					158:164	the exopolysaccharide capsule	136:164	the exopolysaccharide capsule of Streptococcus pneumoniae	136:192	The structure of the exopolysaccharide capsule of Streptococcus pneumoniae is defined by the genetic arrangement of the capsule operon allowing the unequivocal identification of the pneumococcal serotype.
33925509	1	60	theme	operon	247:252	arg1	arrangement					220:230	the genetic arrangement	208:230	the genetic arrangement of the capsule operon allowing the unequivocal identification of the pneumococcal serotype	208:321	The structure of the exopolysaccharide capsule of Streptococcus pneumoniae is defined by the genetic arrangement of the capsule operon allowing the unequivocal identification of the pneumococcal serotype.
33925509	0	61	theme	Capsular	77:84	arg1	Polysaccharide					86:99	Streptococcus pneumoniae Capsular Polysaccharide	52:99	Streptococcus pneumoniae Capsular Polysaccharide	52:99	Carbon Source-Dependent Changes of the Structure of Streptococcus pneumoniae Capsular Polysaccharide with Serotype 6F.
33925509	8	62	theme	6F	1411:1412	arg1	strains					1414:1420	6F strains	1411:1420	6F strains	1411:1420	Therefore, 6F strains may show slightly different polysaccharide composition while colonizing the human nasopharynx (galactose rich) as compared to invasive locations such as the blood (glucose rich).
33925509	5	63	dep	Hyp6AG4	883:889	arg1	specific					892:899	specific	892:899	specific	892:899	Flow cytometric experiments using monoclonal antibodies showed decreased labelling of Hyp6AG4 (specific for serotype 6A) antibodies when 6F is grown in glucose as compared to galactose, which mirrors the 1H-NMR results.
33925509	5	64	theme	Hyp6AG4	883:889	arg1	antibodies					918:927	Hyp6AG4 (specific for serotype 6A) antibodies	883:927	Hyp6AG4 (specific for serotype 6A) antibodies	883:927	Flow cytometric experiments using monoclonal antibodies showed decreased labelling of Hyp6AG4 (specific for serotype 6A) antibodies when 6F is grown in glucose as compared to galactose, which mirrors the 1H-NMR results.
33925509	2	65	theme	S.	419:420	arg1	6F					442:443	S. pneumoniae serotype 6F	419:443	S. pneumoniae serotype 6F	419:443	Here, we investigated the environment-dependent composition of the polysaccharide structure of S. pneumoniae serotype 6F.
33925509	6	66	theme	serotype	1053:1060	arg1	isolates					1065:1072	serotype 6F isolates	1053:1072	serotype 6F isolates	1053:1072	Whole-genome sequencing analyses of serotype 6F isolates suggested that the isolates evolved during two different events from serotype 6A during the time when the 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced.
33925509	5	67	theme	monoclonal	831:840	arg1	antibodies					842:851	monoclonal antibodies	831:851	monoclonal antibodies	831:851	Flow cytometric experiments using monoclonal antibodies showed decreased labelling of Hyp6AG4 (specific for serotype 6A) antibodies when 6F is grown in glucose as compared to galactose, which mirrors the 1H-NMR results.
33925509	6	68	theme	isolates	1065:1072	arg1	analyses					1041:1048	Whole-genome sequencing analyses	1017:1048	Whole-genome sequencing analyses of serotype 6F isolates	1017:1072	Whole-genome sequencing analyses of serotype 6F isolates suggested that the isolates evolved during two different events from serotype 6A during the time when the 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced.
34870467	3	0	theme	lactation	442:450	arg1	stage					452:456	lactation stage	442:456	lactation stage	442:456	Second, we assessed impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition.
34870467	2	1	theme	HMO	265:267	arg1	composition					269:279	HMO composition	265:279	HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women	265:360	The goal of this study was to assess HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women.
34870467	6	2	theme	HMO-bound	797:805	arg1	acid					814:817	HMO-bound sialic acid	797:817	HMO-bound sialic acid	797:817	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	4	3	theme	nonvegetarian	570:582	arg1	women					603:607	nonvegetarian (n = 26) lactating women	570:607	nonvegetarian (n = 26) lactating women	570:607	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	7	4	theme	HMO	992:994	arg1	composition					996:1006	HMO composition	992:1006	HMO composition	992:1006	When adjusting for factors that significantly differed between groups (maternal BMI and lactation stage), no differences in HMO composition were observed.
34870467	10	5	theme	HMO	1545:1547	arg1	β = 0.113					1562:1570	β = 0.113	1562:1570	β = 0.113	1562:1570	Maternal BMI had a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325).
34870467	10	5	theme	HMO	1545:1547	arg1	composition					1549:1559	total HMO composition	1539:1559	total HMO composition (β = 0.113)	1539:1571	Maternal BMI had a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325).
34870467	2	6	theme	lactating	346:354	arg1	women					356:360	vegan, vegetarian, and nonvegetarian lactating women	309:360	vegan, vegetarian, and nonvegetarian lactating women	309:360	The goal of this study was to assess HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women.
34870467	8	7	theme	variables	1077:1085	arg1	13					1059:1060	13	1059:1060	13	1059:1060	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	7	theme	variables	1077:1085	arg1	variables					1077:1085	the outcome variables	1065:1085	the outcome variables	1065:1085	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	0	8	theme	Vegan	74:78	arg1	Mothers					111:117	Vegan, Vegetarian, and Nonvegetarian Mothers	74:117	Vegan, Vegetarian, and Nonvegetarian Mothers	74:117	A Cross-Sectional Assessment of Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers.
34870467	6	9	theme	unadjusted	687:696	arg1	model					708:712	an unadjusted bivariate model	684:712	an unadjusted bivariate model	684:712	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	2	10	theme	milk	291:294	arg1	samples					296:302	breast milk samples	284:302	breast milk samples from vegan, vegetarian, and nonvegetarian lactating women	284:360	The goal of this study was to assess HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women.
34870467	1	11	theme	milk	186:189	arg1	HMOs					209:212	HMOs	209:212	HMOs	209:212	Recently, maternal nutrient intake has been associated with human milk oligosaccharides (HMOs) composition.
34870467	1	11	theme	milk	186:189	arg1	oligosaccharides					191:206	human milk oligosaccharides	180:206	human milk oligosaccharides (HMOs) composition	180:225	Recently, maternal nutrient intake has been associated with human milk oligosaccharides (HMOs) composition.
34870467	9	12	theme	strongest	1342:1350	arg1	impact					1361:1366	the strongest positive impact	1338:1366	the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433)	1338:1404	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	8	13	theme	positive	1106:1113	arg1	relationship					1115:1126	the strongest positive relationship	1092:1126	the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910)	1092:1186	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	6	14	theme	diet	856:859	arg1	group					861:865	diet group	856:865	diet group	856:865	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	6	15	from	difference	728:737	arg1	scores					846:851	diversity and evenness scores	823:851	diversity and evenness scores	823:851	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	6	15	from	difference	728:737	arg1	fucose					786:791	total HMO-bound fucose	770:791	total HMO-bound fucose	770:791	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	6	15	from	difference	728:737	arg1	composition					757:767	individual HMO composition	742:767	individual HMO composition	742:767	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	7	16	from	differences	977:987	arg1	composition					996:1006	HMO composition	992:1006	HMO composition	992:1006	When adjusting for factors that significantly differed between groups (maternal BMI and lactation stage), no differences in HMO composition were observed.
34870467	7	17	theme	maternal	939:946	arg1	BMI					948:950	maternal BMI	939:950	maternal BMI	939:950	When adjusting for factors that significantly differed between groups (maternal BMI and lactation stage), no differences in HMO composition were observed.
34870467	7	17	theme	maternal	939:946	arg1	groups					931:936	groups	931:936	groups (maternal BMI and lactation stage)	931:971	When adjusting for factors that significantly differed between groups (maternal BMI and lactation stage), no differences in HMO composition were observed.
34870467	2	18	theme	study	245:249	arg1	goal					232:235	The goal	228:235	The goal of this study	228:249	The goal of this study was to assess HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women.
34870467	1	19	theme	maternal	130:137	arg1	intake					148:153	maternal nutrient intake	130:153	maternal nutrient intake	130:153	Recently, maternal nutrient intake has been associated with human milk oligosaccharides (HMOs) composition.
34870467	2	20	from	composition	269:279	arg1	women					356:360	vegan, vegetarian, and nonvegetarian lactating women	309:360	vegan, vegetarian, and nonvegetarian lactating women	309:360	The goal of this study was to assess HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women.
34870467	2	20	from	composition	269:279	arg1	samples					296:302	breast milk samples	284:302	breast milk samples from vegan, vegetarian, and nonvegetarian lactating women	284:360	The goal of this study was to assess HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women.
34870467	8	21	with	relationship	1115:1126	arg1	HMO					1139:1141	total HMO	1133:1141	total HMO (β = 0.922)	1133:1153	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	21	with	relationship	1115:1126	arg1	LSTb					1261:1264	LSTb	1261:1264	LSTb	1261:1264	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	21	with	relationship	1115:1126	arg1	β = 0.922					1144:1152	β = 0.922	1144:1152	β = 0.922	1144:1152	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	21	with	relationship	1115:1126	arg1	β = 0.910					1177:1185	β = 0.910	1177:1185	β = 0.910	1177:1185	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	21	with	relationship	1115:1126	arg1	β = -0.544					1268:1277	β = -0.544	1268:1277	β = -0.544	1268:1277	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	21	with	relationship	1115:1126	arg1	b					1258:1258	sialyl-lacto-N-tetraose b	1234:1258	sialyl-lacto-N-tetraose b (LSTb) (β = -0.544)	1234:1278	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	21	with	relationship	1115:1126	arg1	fucose					1169:1174	HMO-bound fucose	1159:1174	HMO-bound fucose (β = 0.910)	1159:1186	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	4	22	theme	lactating	593:601	arg1	women					603:607	nonvegetarian (n = 26) lactating women	570:607	nonvegetarian (n = 26) lactating women	570:607	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	8	23	theme	negative	1207:1214	arg1	relationship					1216:1227	the strongest negative relationship	1193:1227	the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544)	1193:1278	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	3	24	from	impact	383:388	arg1	composition					465:475	HMO composition	461:475	HMO composition	461:475	Second, we assessed impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition.
34870467	4	25	from	vegan	529:533	arg1	analysis					496:503	A cross-sectional analysis	478:503	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women	478:607	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	4	25	from	vegan	529:533	arg1	composition					512:522	HMO composition	508:522	HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women	508:607	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	3	26	theme	mass	407:410	arg1	BMI					419:421	BMI	419:421	BMI	419:421	Second, we assessed impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition.
34870467	3	26	theme	mass	407:410	arg1	index					412:416	maternal body mass index	393:416	maternal body mass index (BMI)	393:422	Second, we assessed impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition.
34870467	0	27	theme	Nonvegetarian	97:109	arg1	Mothers					111:117	Vegan, Vegetarian, and Nonvegetarian Mothers	74:117	Vegan, Vegetarian, and Nonvegetarian Mothers	74:117	A Cross-Sectional Assessment of Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers.
34870467	5	28	theme	dietary	660:666	arg1	supplements					668:678	dietary supplements	660:678	dietary supplements	660:678	The majority of participants took dietary supplements.
34870467	7	29	dep	groups	931:936	arg1	BMI					948:950	maternal BMI	939:950	maternal BMI	939:950	When adjusting for factors that significantly differed between groups (maternal BMI and lactation stage), no differences in HMO composition were observed.
34870467	7	29	dep	groups	931:936	arg1	stage					966:970	lactation stage	956:970	lactation stage	956:970	When adjusting for factors that significantly differed between groups (maternal BMI and lactation stage), no differences in HMO composition were observed.
34870467	7	29	dep	groups	931:936	arg1	groups					931:936	groups	931:936	groups (maternal BMI and lactation stage)	931:971	When adjusting for factors that significantly differed between groups (maternal BMI and lactation stage), no differences in HMO composition were observed.
34870467	3	30	theme	maternal	393:400	arg1	BMI					419:421	BMI	419:421	BMI	419:421	Second, we assessed impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition.
34870467	3	30	theme	maternal	393:400	arg1	index					412:416	maternal body mass index	393:416	maternal body mass index (BMI)	393:422	Second, we assessed impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition.
34870467	4	31	theme	cross-sectional	480:494	arg1	analysis					496:503	A cross-sectional analysis	478:503	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women	478:607	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	10	32	dep	significant	1500:1510	arg1	positive					1512:1519	positive	1512:1519	positive	1512:1519	Maternal BMI had a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325).
34870467	10	33	theme	Maternal	1481:1488	arg1	BMI					1490:1492	Maternal BMI	1481:1492	Maternal BMI	1481:1492	Maternal BMI had a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325).
34870467	6	34	theme	HMO-bound	776:784	arg1	fucose					786:791	total HMO-bound fucose	770:791	total HMO-bound fucose	770:791	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	9	35	theme	strongest	1415:1423	arg1	impact					1434:1439	the strongest negative impact	1411:1439	the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519)	1411:1478	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	0	36	theme	Human	32:36	arg1	Composition					59:69	Human Milk Oligosaccharide Composition	32:69	Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers	32:117	A Cross-Sectional Assessment of Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers.
34870467	2	37	theme	vegetarian	316:325	arg1	women					356:360	vegan, vegetarian, and nonvegetarian lactating women	309:360	vegan, vegetarian, and nonvegetarian lactating women	309:360	The goal of this study was to assess HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women.
34870467	3	38	theme	parity	430:435	arg1	impact					383:388	impact	383:388	impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition	383:475	Second, we assessed impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition.
34870467	0	39	theme	Oligosaccharide	43:57	arg1	Composition					59:69	Human Milk Oligosaccharide Composition	32:69	Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers	32:117	A Cross-Sectional Assessment of Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers.
34870467	6	40	theme	HMO	753:755	arg1	composition					757:767	individual HMO composition	742:767	individual HMO composition	742:767	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	2	41	theme	vegan	309:313	arg1	women					356:360	vegan, vegetarian, and nonvegetarian lactating women	309:360	vegan, vegetarian, and nonvegetarian lactating women	309:360	The goal of this study was to assess HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women.
34870467	3	42	theme	stage	452:456	arg1	impact					383:388	impact	383:388	impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition	383:475	Second, we assessed impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition.
34870467	8	43	theme	Secretor	1023:1030	arg1	status					1032:1037	Secretor status	1023:1037	Secretor status	1023:1037	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	6	44	theme	diversity	823:831	arg1	scores					846:851	diversity and evenness scores	823:851	diversity and evenness scores	823:851	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	4	45	from	women	603:607	arg1	analysis					496:503	A cross-sectional analysis	478:503	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women	478:607	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	4	45	from	women	603:607	arg1	composition					512:522	HMO composition	508:522	HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women	508:607	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	4	46	theme	composition	512:522	arg1	analysis					496:503	A cross-sectional analysis	478:503	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women	478:607	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	6	47	theme	sialic	807:812	arg1	acid					814:817	HMO-bound sialic acid	797:817	HMO-bound sialic acid	797:817	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	2	48	from	women	356:360	arg1	composition					269:279	HMO composition	265:279	HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women	265:360	The goal of this study was to assess HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women.
34870467	2	48	from	women	356:360	arg1	samples					296:302	breast milk samples	284:302	breast milk samples from vegan, vegetarian, and nonvegetarian lactating women	284:360	The goal of this study was to assess HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women.
34870467	10	49	theme	significant	1500:1510	arg1	relationship					1521:1532	a significant positive relationship	1498:1532	a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325)	1498:1592	Maternal BMI had a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325).
34870467	3	50	theme	HMO	461:463	arg1	composition					465:475	HMO composition	461:475	HMO composition	461:475	Second, we assessed impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition.
34870467	8	51	theme	total	1133:1137	arg1	β = 0.922					1144:1152	β = 0.922	1144:1152	β = 0.922	1144:1152	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	51	theme	total	1133:1137	arg1	HMO					1139:1141	total HMO	1133:1141	total HMO (β = 0.922)	1133:1153	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	6	52	theme	bivariate	698:706	arg1	model					708:712	an unadjusted bivariate model	684:712	an unadjusted bivariate model	684:712	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	1	53	theme	human	180:184	arg1	HMOs					209:212	HMOs	209:212	HMOs	209:212	Recently, maternal nutrient intake has been associated with human milk oligosaccharides (HMOs) composition.
34870467	1	53	theme	human	180:184	arg1	oligosaccharides					191:206	human milk oligosaccharides	180:206	human milk oligosaccharides (HMOs) composition	180:225	Recently, maternal nutrient intake has been associated with human milk oligosaccharides (HMOs) composition.
34870467	8	54	theme	outcome	1069:1075	arg1	variables					1077:1085	the outcome variables	1065:1085	the outcome variables	1065:1085	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	10	55	with	relationship	1521:1532	arg1	β = 0.325					1583:1591	β = 0.325	1583:1591	β = 0.325	1583:1591	Maternal BMI had a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325).
34870467	10	55	with	relationship	1521:1532	arg1	SL					1579:1580	3'SL	1577:1580	3'SL (β = 0.325)	1577:1592	Maternal BMI had a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325).
34870467	10	55	with	relationship	1521:1532	arg1	β = 0.113					1562:1570	β = 0.113	1562:1570	β = 0.113	1562:1570	Maternal BMI had a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325).
34870467	10	55	with	relationship	1521:1532	arg1	composition					1549:1559	total HMO composition	1539:1559	total HMO composition (β = 0.113)	1539:1571	Maternal BMI had a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325).
34870467	2	56	theme	breast	284:289	arg1	samples					296:302	breast milk samples	284:302	breast milk samples from vegan, vegetarian, and nonvegetarian lactating women	284:360	The goal of this study was to assess HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women.
34870467	1	57	theme	oligosaccharides	191:206	arg1	composition					215:225	human milk oligosaccharides (HMOs) composition	180:225	human milk oligosaccharides (HMOs) composition	180:225	Recently, maternal nutrient intake has been associated with human milk oligosaccharides (HMOs) composition.
34870467	10	58	contain	had	1494:1496	arg1	BMI					1490:1492	Maternal BMI	1481:1492	Maternal BMI	1481:1492	Maternal BMI had a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325).
34870467	10	58	contain	had	1494:1496	arg2	relationship					1521:1532	a significant positive relationship	1498:1532	a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325)	1498:1592	Maternal BMI had a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325).
34870467	7	59	theme	lactation	956:964	arg1	stage					966:970	lactation stage	956:970	lactation stage	956:970	When adjusting for factors that significantly differed between groups (maternal BMI and lactation stage), no differences in HMO composition were observed.
34870467	7	59	theme	lactation	956:964	arg1	groups					931:936	groups	931:936	groups (maternal BMI and lactation stage)	931:971	When adjusting for factors that significantly differed between groups (maternal BMI and lactation stage), no differences in HMO composition were observed.
34870467	9	60	theme	positive	1352:1359	arg1	impact					1361:1366	the strongest positive impact	1338:1366	the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433)	1338:1404	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	8	61	theme	strongest	1096:1104	arg1	relationship					1115:1126	the strongest positive relationship	1092:1126	the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910)	1092:1186	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	62	theme	HMO-bound	1159:1167	arg1	β = 0.910					1177:1185	β = 0.910	1177:1185	β = 0.910	1177:1185	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	62	theme	HMO-bound	1159:1167	arg1	fucose					1169:1174	HMO-bound fucose	1159:1174	HMO-bound fucose (β = 0.910)	1159:1186	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	6	63	theme	evenness	837:844	arg1	scores					846:851	diversity and evenness scores	823:851	diversity and evenness scores	823:851	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	11	64	theme	Lactating	1595:1603	arg1	women					1605:1609	Lactating women	1595:1609	Lactating women who consume plant-based diets	1595:1639	Lactating women who consume plant-based diets do not produce different breast milk as it relates to HMO composition.
34870467	3	65	theme	age	425:427	arg1	impact					383:388	impact	383:388	impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition	383:475	Second, we assessed impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition.
34870467	4	66	from	vegetarian	545:554	arg1	analysis					496:503	A cross-sectional analysis	478:503	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women	478:607	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	4	66	from	vegetarian	545:554	arg1	composition					512:522	HMO composition	508:522	HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women	508:607	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	1	67	theme	nutrient	139:146	arg1	intake					148:153	maternal nutrient intake	130:153	maternal nutrient intake	130:153	Recently, maternal nutrient intake has been associated with human milk oligosaccharides (HMOs) composition.
34870467	8	68	with	relationship	1216:1227	arg1	HMO					1139:1141	total HMO	1133:1141	total HMO (β = 0.922)	1133:1153	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	68	with	relationship	1216:1227	arg1	LSTb					1261:1264	LSTb	1261:1264	LSTb	1261:1264	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	68	with	relationship	1216:1227	arg1	β = 0.922					1144:1152	β = 0.922	1144:1152	β = 0.922	1144:1152	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	68	with	relationship	1216:1227	arg1	β = 0.910					1177:1185	β = 0.910	1177:1185	β = 0.910	1177:1185	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	68	with	relationship	1216:1227	arg1	β = -0.544					1268:1277	β = -0.544	1268:1277	β = -0.544	1268:1277	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	68	with	relationship	1216:1227	arg1	b					1258:1258	sialyl-lacto-N-tetraose b	1234:1258	sialyl-lacto-N-tetraose b (LSTb) (β = -0.544)	1234:1278	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	68	with	relationship	1216:1227	arg1	fucose					1169:1174	HMO-bound fucose	1159:1174	HMO-bound fucose (β = 0.910)	1159:1186	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	0	69	theme	Vegetarian	81:90	arg1	Mothers					111:117	Vegan, Vegetarian, and Nonvegetarian Mothers	74:117	Vegan, Vegetarian, and Nonvegetarian Mothers	74:117	A Cross-Sectional Assessment of Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers.
34870467	8	70	theme	strongest	1197:1205	arg1	relationship					1216:1227	the strongest negative relationship	1193:1227	the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544)	1193:1278	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	11	71	theme	plant-based	1623:1633	arg1	diets					1635:1639	plant-based diets	1623:1639	plant-based diets	1623:1639	Lactating women who consume plant-based diets do not produce different breast milk as it relates to HMO composition.
34870467	0	72	theme	Mothers	111:117	arg1	Composition					59:69	Human Milk Oligosaccharide Composition	32:69	Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers	32:117	A Cross-Sectional Assessment of Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers.
34870467	8	73	theme	sialyl-lacto-N-tetraose	1234:1256	arg1	LSTb					1261:1264	LSTb	1261:1264	LSTb	1261:1264	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	73	theme	sialyl-lacto-N-tetraose	1234:1256	arg1	β = -0.544					1268:1277	β = -0.544	1268:1277	β = -0.544	1268:1277	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	8	73	theme	sialyl-lacto-N-tetraose	1234:1256	arg1	b					1258:1258	sialyl-lacto-N-tetraose b	1234:1258	sialyl-lacto-N-tetraose b (LSTb) (β = -0.544)	1234:1278	Secretor status was significant for 13 of the outcome variables with the strongest positive relationship with total HMO (β = 0.922) and HMO-bound fucose (β = 0.910), and the strongest negative relationship with sialyl-lacto-N-tetraose b (LSTb) (β = -0.544).
34870467	3	74	theme	index	412:416	arg1	impact					383:388	impact	383:388	impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition	383:475	Second, we assessed impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition.
34870467	0	75	theme	Cross-Sectional	2:16	arg1	Assessment					18:27	A Cross-Sectional Assessment	0:27	A Cross-Sectional Assessment of Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers.	0:118	A Cross-Sectional Assessment of Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers.
34870467	11	76	theme	different	1656:1664	arg1	milk					1673:1676	different breast milk	1656:1676	different breast milk	1656:1676	Lactating women who consume plant-based diets do not produce different breast milk as it relates to HMO composition.
34870467	3	77	theme	body	402:405	arg1	BMI					419:421	BMI	419:421	BMI	419:421	Second, we assessed impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition.
34870467	3	77	theme	body	402:405	arg1	index					412:416	maternal body mass index	393:416	maternal body mass index (BMI)	393:422	Second, we assessed impact of maternal body mass index (BMI), age, parity, and lactation stage on HMO composition.
34870467	4	78	from	analysis	496:503	arg1	vegan					529:533	vegan (n = 26)	529:542	vegan (n = 26)	529:542	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	4	78	from	analysis	496:503	arg1	women					603:607	nonvegetarian (n = 26) lactating women	570:607	nonvegetarian (n = 26) lactating women	570:607	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	4	78	from	analysis	496:503	arg1	n = 22					557:562	n = 22	557:562	n = 22	557:562	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	4	78	from	analysis	496:503	arg1	vegetarian					545:554	vegetarian	545:554	vegetarian (n = 22)	545:563	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	4	79	theme	HMO	508:510	arg1	composition					512:522	HMO composition	508:522	HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women	508:607	A cross-sectional analysis of HMO composition from vegan (n = 26), vegetarian (n = 22), and nonvegetarian (n = 26) lactating women was carried out.
34870467	10	80	theme	total	1539:1543	arg1	β = 0.113					1562:1570	β = 0.113	1562:1570	β = 0.113	1562:1570	Maternal BMI had a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325).
34870467	10	80	theme	total	1539:1543	arg1	composition					1549:1559	total HMO composition	1539:1559	total HMO composition (β = 0.113)	1539:1571	Maternal BMI had a significant positive relationship with total HMO composition (β = 0.113) and 3'SL (β = 0.325).
34870467	0	81	theme	Milk	38:41	arg1	Composition					59:69	Human Milk Oligosaccharide Composition	32:69	Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers	32:117	A Cross-Sectional Assessment of Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers.
34870467	6	82	theme	total	770:774	arg1	fucose					786:791	total HMO-bound fucose	770:791	total HMO-bound fucose	770:791	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	9	83	theme	negative	1425:1432	arg1	impact					1434:1439	the strongest negative impact	1411:1439	the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519)	1411:1478	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	9	84	from	impact	1434:1439	arg1	SL					1463:1464	6'SL	1461:1464	6'SL	1461:1464	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	9	84	from	impact	1434:1439	arg1	SL					1390:1391	3'SL	1388:1391	3'SL	1388:1391	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	9	84	from	impact	1434:1439	arg1	sialyllactose					1446:1458	6'sialyllactose	1444:1458	6'sialyllactose (6'SL) (β = -0.519)	1444:1478	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	9	84	from	impact	1434:1439	arg1	sialyllactose					1373:1385	3'sialyllactose	1371:1385	3'sialyllactose (3'SL) (β = 0.433)	1371:1404	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	9	84	from	impact	1434:1439	arg1	β = -0.519					1468:1477	β = -0.519	1468:1477	β = -0.519	1468:1477	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	9	84	from	impact	1434:1439	arg1	β = 0.433					1395:1403	β = 0.433	1395:1403	β = 0.433	1395:1403	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	9	85	with	significant	1301:1311	arg1	impact					1434:1439	the strongest negative impact	1411:1439	the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519)	1411:1478	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	9	85	with	significant	1301:1311	arg1	impact					1361:1366	the strongest positive impact	1338:1366	the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433)	1338:1404	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	11	86	theme	HMO	1695:1697	arg1	composition					1699:1709	HMO composition	1695:1709	HMO composition	1695:1709	Lactating women who consume plant-based diets do not produce different breast milk as it relates to HMO composition.
34870467	0	87	theme	Composition	59:69	arg1	Assessment					18:27	A Cross-Sectional Assessment	0:27	A Cross-Sectional Assessment of Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers.	0:118	A Cross-Sectional Assessment of Human Milk Oligosaccharide Composition of Vegan, Vegetarian, and Nonvegetarian Mothers.
34870467	9	88	from	impact	1361:1366	arg1	SL					1463:1464	6'SL	1461:1464	6'SL	1461:1464	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	9	88	from	impact	1361:1366	arg1	SL					1390:1391	3'SL	1388:1391	3'SL	1388:1391	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	9	88	from	impact	1361:1366	arg1	sialyllactose					1446:1458	6'sialyllactose	1444:1458	6'sialyllactose (6'SL) (β = -0.519)	1444:1478	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	9	88	from	impact	1361:1366	arg1	sialyllactose					1373:1385	3'sialyllactose	1371:1385	3'sialyllactose (3'SL) (β = 0.433)	1371:1404	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	9	88	from	impact	1361:1366	arg1	β = -0.519					1468:1477	β = -0.519	1468:1477	β = -0.519	1468:1477	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	9	88	from	impact	1361:1366	arg1	β = 0.433					1395:1403	β = 0.433	1395:1403	β = 0.433	1395:1403	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
34870467	6	89	theme	individual	742:751	arg1	composition					757:767	individual HMO composition	742:767	individual HMO composition	742:767	In an unadjusted bivariate model, there was no difference in individual HMO composition, total HMO-bound fucose and HMO-bound sialic acid, or diversity and evenness scores by diet group.
34870467	5	90	theme	participants	642:653	arg1	majority					630:637	The majority	626:637	The majority of participants	626:653	The majority of participants took dietary supplements.
34870467	11	91	theme	breast	1666:1671	arg1	milk					1673:1676	different breast milk	1656:1676	different breast milk	1656:1676	Lactating women who consume plant-based diets do not produce different breast milk as it relates to HMO composition.
34870467	2	92	theme	nonvegetarian	332:344	arg1	women					356:360	vegan, vegetarian, and nonvegetarian lactating women	309:360	vegan, vegetarian, and nonvegetarian lactating women	309:360	The goal of this study was to assess HMO composition in breast milk samples from vegan, vegetarian, and nonvegetarian lactating women.
34870467	9	93	theme	Lactation	1281:1289	arg1	stage					1291:1295	Lactation stage	1281:1295	Lactation stage	1281:1295	Lactation stage was significant for eight analytes, with the strongest positive impact on 3'sialyllactose (3'SL) (β = 0.433), and the strongest negative impact on 6'sialyllactose (6'SL) (β = -0.519).
33388571	3	0	theme	morphological	647:659	arg1	changes					661:667	promoted chemical and morphological changes	625:667	promoted chemical and morphological changes to the PCs	625:678	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv) evaluated promoted chemical and morphological changes to the PCs.
33388571	0	1	theme	properties	168:177	arg1	treatment					19:27	chemical treatment	10:27	chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials	10:201	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	6	2	theme	isolated	1315:1322	arg1	cellulose					1324:1332	the isolated cellulose	1311:1332	the isolated cellulose	1311:1332	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	0	3	theme	cellulosic	182:191	arg1	materials					193:201	cellulosic materials	182:201	cellulosic materials	182:201	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	6	4	dep	2B_KOH	1368:1373	arg1	for					1363:1365	for	1363:1365	for	1363:1365	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	6	5	with	2B_KOH	1552:1557	arg1	cellulose					1573:1581	cellulose	1573:1581	cellulose	1573:1581	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	6	5	with	2B_KOH	1552:1557	arg1	%					1568:1568	74.6%	1564:1568	74.6% of cellulose	1564:1581	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	5	6	theme	bleaching	1106:1114	arg1	AT					1042:1043	AT	1042:1043	AT	1042:1043	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	5	6	theme	bleaching	1106:1114	arg1	step					1116:1119	the second bleaching step	1095:1119	the second bleaching step	1095:1119	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	6	7	theme	350 °C.	1379:1385	arg1	degradation					1351:1361	the maximum degradation	1339:1361	the maximum degradation for (2B_KOH)	1339:1374	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	6	7	theme	350 °C.	1379:1385	arg1	composition					1396:1406	350 °C. Chemical composition	1379:1406	350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose	1379:1581	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	4	8	theme	electron	807:814	arg1	SEM					828:830	SEM	828:830	SEM	828:830	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	4	8	theme	electron	807:814	arg1	microscopy					816:825	Scanning electron microscopy	798:825	Scanning electron microscopy (SEM)	798:831	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	6	9	from	analysis	1256:1263	arg1	Results					1231:1237	Results	1231:1237	Results from the thermal analysis	1231:1263	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	7	10	theme	morphological	1612:1624	arg1	structure					1626:1634	the morphological structure	1608:1634	the morphological structure on fibers	1608:1644	SEM revealed changes in the morphological structure on fibers.
33388571	7	11	from	changes	1597:1603	arg1	structure					1626:1634	the morphological structure	1608:1634	the morphological structure on fibers	1608:1644	SEM revealed changes in the morphological structure on fibers.
33388571	7	11	from	changes	1597:1603	arg1	fibers					1639:1644	fibers	1639:1644	fibers	1639:1644	SEM revealed changes in the morphological structure on fibers.
33388571	0	12	theme	structure	107:115	arg1	properties					168:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties	32:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials	32:201	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	5	13	theme	crystallinity	995:1007	arg1	index					1009:1013	the crystallinity index	991:1013	the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH)	991:1154	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	0	14	theme	thermal	118:124	arg1	stability					126:134	thermal stability	118:134	thermal stability	118:134	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	4	15	theme	thermogravimetric	834:850	arg1	analysis					852:859	thermogravimetric analysis	834:859	thermogravimetric analysis (TG)	834:864	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	4	15	theme	thermogravimetric	834:850	arg1	TG					862:863	TG	862:863	TG	862:863	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	6	16	theme	high-quality	1539:1550	arg1	2B_KOH					1552:1557	high-quality 2B_KOH	1539:1557	high-quality 2B_KOH with 74.6% of cellulose	1539:1581	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	1	17	theme	industrial	401:410	arg1	applications					412:423	various industrial applications	393:423	various industrial applications	393:423	Recently, the growing environmental concerns and economic demands have driven the need to develop effective solutions for the treatment of vegetal fibers to be used as renewable source for various industrial applications.
33388571	8	18	theme	excellent	1699:1707	arg1	treatment					1656:1664	Alkaline treatment	1647:1664	Alkaline treatment followed by H2O2 bleaching	1647:1691	Alkaline treatment followed by H2O2 bleaching is an excellent alternative for the removal of non-cellulosic material and facilitates the isolation of cellulose.
33388571	8	18	theme	excellent	1699:1707	arg1	alternative					1709:1719	an excellent alternative	1696:1719	an excellent alternative for the removal of non-cellulosic material	1696:1762	Alkaline treatment followed by H2O2 bleaching is an excellent alternative for the removal of non-cellulosic material and facilitates the isolation of cellulose.
33388571	0	19	theme	degradation	148:158	arg1	properties					168:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties	32:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials	32:201	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	6	20	theme	alkaline	1508:1515	arg1	treatment					1517:1525	alkaline treatment	1508:1525	alkaline treatment	1508:1525	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	6	21	theme	thermal	1279:1285	arg1	stability					1287:1295	thermal stability	1279:1295	thermal stability	1279:1295	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	8	22	theme	H2O2	1678:1681	arg1	bleaching					1683:1691	H2O2 bleaching	1678:1691	H2O2 bleaching	1678:1691	Alkaline treatment followed by H2O2 bleaching is an excellent alternative for the removal of non-cellulosic material and facilitates the isolation of cellulose.
33388571	1	23	theme	vegetal	343:349	arg1	fibers					351:356	vegetal fibers	343:356	vegetal fibers	343:356	Recently, the growing environmental concerns and economic demands have driven the need to develop effective solutions for the treatment of vegetal fibers to be used as renewable source for various industrial applications.
33388571	4	24	theme	Fourier-transform	725:741	arg1	FTIR					766:769	FTIR	766:769	FTIR	766:769	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	4	24	theme	Fourier-transform	725:741	arg1	spectroscopy					752:763	Fourier-transform infrared spectroscopy	725:763	Fourier-transform infrared spectroscopy (FTIR)	725:770	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	0	25	theme	chemical	73:80	arg1	composition					82:92	chemical composition	73:92	chemical composition	73:92	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	5	26	theme	fibers	1022:1027	arg1	index					1009:1013	the crystallinity index	991:1013	the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH)	991:1154	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	6	27	theme	soluble	1484:1490	arg1	materials					1492:1500	other soluble materials	1478:1500	other soluble materials	1478:1500	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	2	28	theme	alternative	496:506	arg1	source					508:513	an alternative source	493:513	an alternative source of cellulose	493:526	The present study aimed to explore pineapple crown fibers (PCs) as an alternative source of cellulose.
33388571	2	28	theme	alternative	496:506	arg1	fibers					477:482	pineapple crown fibers	461:482	pineapple crown fibers (PCs)	461:488	The present study aimed to explore pineapple crown fibers (PCs) as an alternative source of cellulose.
33388571	6	29	theme	cellulose	1573:1581	arg1	cellulose					1573:1581	cellulose	1573:1581	cellulose	1573:1581	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	6	29	theme	cellulose	1573:1581	arg1	%					1568:1568	74.6%	1564:1568	74.6% of cellulose	1564:1581	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	0	30	theme	chemical	10:17	arg1	treatment					19:27	chemical treatment	10:27	chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials	10:201	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	9	31	theme	methodology	1922:1932	arg1	treatment					1907:1915	treatment	1907:1915	treatment of a methodology by chlorite-free	1907:1949	These results suggested that there is a potential to isolate cellulose from PC via the sequence of treatment of a methodology by chlorite-free.
33388571	1	32	theme	effective	302:310	arg1	solutions					312:320	effective solutions	302:320	effective solutions	302:320	Recently, the growing environmental concerns and economic demands have driven the need to develop effective solutions for the treatment of vegetal fibers to be used as renewable source for various industrial applications.
33388571	2	33	theme	pineapple	461:469	arg1	source					508:513	an alternative source	493:513	an alternative source of cellulose	493:526	The present study aimed to explore pineapple crown fibers (PCs) as an alternative source of cellulose.
33388571	2	33	theme	pineapple	461:469	arg1	PCs					485:487	PCs	485:487	PCs	485:487	The present study aimed to explore pineapple crown fibers (PCs) as an alternative source of cellulose.
33388571	2	33	theme	pineapple	461:469	arg1	fibers					477:482	pineapple crown fibers	461:482	pineapple crown fibers (PCs)	461:488	The present study aimed to explore pineapple crown fibers (PCs) as an alternative source of cellulose.
33388571	6	34	theme	thermal	1248:1254	arg1	analysis					1256:1263	the thermal analysis	1244:1263	the thermal analysis	1244:1263	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	5	35	theme	bleaching	1075:1083	arg1	step					1085:1088	second bleaching step	1068:1088	second bleaching step	1068:1088	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	5	35	theme	bleaching	1075:1083	arg1	AT					1042:1043	AT	1042:1043	AT	1042:1043	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	8	36	theme	non-cellulosic	1740:1753	arg1	material					1755:1762	non-cellulosic material	1740:1762	non-cellulosic material	1740:1762	Alkaline treatment followed by H2O2 bleaching is an excellent alternative for the removal of non-cellulosic material and facilitates the isolation of cellulose.
33388571	6	37	theme	maximum	1343:1349	arg1	2B_KOH					1368:1373	2B_KOH	1368:1373	2B_KOH	1368:1373	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	6	37	theme	maximum	1343:1349	arg1	composition					1396:1406	350 °C. Chemical composition	1379:1406	350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose	1379:1581	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	6	37	theme	maximum	1343:1349	arg1	degradation					1351:1361	the maximum degradation	1339:1361	the maximum degradation for (2B_KOH)	1339:1374	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	5	38	theme	KOH	1133:1135	arg1	treatment					1137:1145	KOH treatment	1133:1145	KOH treatment (2B_KOH)	1133:1154	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	5	38	theme	KOH	1133:1135	arg1	2B_KOH					1148:1153	2B_KOH	1148:1153	2B_KOH	1148:1153	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	5	39	theme	Cellulose-I	925:935	arg1	allomorph					937:945	the Cellulose-I allomorph	921:945	the Cellulose-I allomorph	921:945	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	3	40	theme	promoted	625:632	arg1	changes					661:667	promoted chemical and morphological changes	625:667	promoted chemical and morphological changes to the PCs	625:678	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv) evaluated promoted chemical and morphological changes to the PCs.
33388571	0	41	from	structure	107:115	arg1	production					61:70	the production	57:70	the production	57:70	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	1	42	theme	economic	253:260	arg1	demands					262:268	economic demands	253:268	economic demands	253:268	Recently, the growing environmental concerns and economic demands have driven the need to develop effective solutions for the treatment of vegetal fibers to be used as renewable source for various industrial applications.
33388571	0	43	from	degradation	148:158	arg1	production					61:70	the production	57:70	the production	57:70	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	0	44	theme	materials	193:201	arg1	properties					168:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties	32:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials	32:201	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	8	45	theme	material	1755:1762	arg1	removal					1729:1735	the removal	1725:1735	the removal of non-cellulosic material	1725:1762	Alkaline treatment followed by H2O2 bleaching is an excellent alternative for the removal of non-cellulosic material and facilitates the isolation of cellulose.
33388571	6	46	theme	Chemical	1387:1394	arg1	degradation					1351:1361	the maximum degradation	1339:1361	the maximum degradation for (2B_KOH)	1339:1374	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	6	46	theme	Chemical	1387:1394	arg1	composition					1396:1406	350 °C. Chemical composition	1379:1406	350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose	1379:1581	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	0	47	theme	crown	42:46	arg1	fiber					48:52	pineapple crown fiber	32:52	pineapple crown fiber in the production	32:70	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	3	48	theme	alcohol-insoluble	551:567	arg1	AIR					578:580	AIR	578:580	AIR	578:580	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv) evaluated promoted chemical and morphological changes to the PCs.
33388571	3	48	theme	alcohol-insoluble	551:567	arg1	treatments					539:548	The three treatments	529:548	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv)	529:613	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv) evaluated promoted chemical and morphological changes to the PCs.
33388571	3	48	theme	alcohol-insoluble	551:567	arg1	residue					569:575	alcohol-insoluble residue	551:575	alcohol-insoluble residue (AIR)	551:581	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv) evaluated promoted chemical and morphological changes to the PCs.
33388571	5	49	theme	bleaching	1052:1060	arg1	AT					1042:1043	AT	1042:1043	AT	1042:1043	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	5	49	theme	bleaching	1052:1060	arg1	step					1062:1065	first bleaching step	1046:1065	first bleaching step	1046:1065	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	4	50	theme	Scanning	798:805	arg1	SEM					828:830	SEM	828:830	SEM	828:830	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	4	50	theme	Scanning	798:805	arg1	microscopy					816:825	Scanning electron microscopy	798:825	Scanning electron microscopy (SEM)	798:831	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	6	51	dep	composition	1396:1406	arg1	showed					1416:1421	showed	1416:1421	showed	1416:1421	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	1	52	dep	concerns	240:247	arg1	the					214:216	the	214:216	the	214:216	Recently, the growing environmental concerns and economic demands have driven the need to develop effective solutions for the treatment of vegetal fibers to be used as renewable source for various industrial applications.
33388571	0	53	theme	stability	126:134	arg1	properties					168:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties	32:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials	32:201	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	2	54	theme	cellulose	518:526	arg1	source					508:513	an alternative source	493:513	an alternative source of cellulose	493:526	The present study aimed to explore pineapple crown fibers (PCs) as an alternative source of cellulose.
33388571	2	54	theme	cellulose	518:526	arg1	fibers					477:482	pineapple crown fibers	461:482	pineapple crown fibers (PCs)	461:488	The present study aimed to explore pineapple crown fibers (PCs) as an alternative source of cellulose.
33388571	0	55	theme	thermal	140:146	arg1	degradation					148:158	thermal degradation	140:158	thermal degradation	140:158	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	1	56	theme	various	393:399	arg1	applications					412:423	various industrial applications	393:423	various industrial applications	393:423	Recently, the growing environmental concerns and economic demands have driven the need to develop effective solutions for the treatment of vegetal fibers to be used as renewable source for various industrial applications.
33388571	9	57	attach	isolate	1861:1867	arg2	potential					1848:1856	a potential to isolate cellulose from PC via the sequence of treatment of a methodology by chlorite-free	1846:1949	a potential to isolate cellulose from PC via the sequence of treatment of a methodology by chlorite-free	1846:1949	These results suggested that there is a potential to isolate cellulose from PC via the sequence of treatment of a methodology by chlorite-free.
33388571	9	57	attach	isolate	1861:1867	arg1	PC					1884:1885	PC	1884:1885	PC via the sequence of treatment of a methodology by chlorite-free	1884:1949	These results suggested that there is a potential to isolate cellulose from PC via the sequence of treatment of a methodology by chlorite-free.
33388571	0	58	theme	kinetic	160:166	arg1	properties					168:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties	32:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials	32:201	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	0	59	from	composition	82:92	arg1	production					61:70	the production	57:70	the production	57:70	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	4	60	theme	Fresh	681:685	arg1	PCs					699:701	Fresh and treated PCs	681:701	Fresh and treated PCs	681:701	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	3	61	dep	treatments	539:548	arg1	treatments					539:548	The three treatments	529:548	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv)	529:613	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv) evaluated promoted chemical and morphological changes to the PCs.
33388571	3	61	dep	treatments	539:548	arg1	organosolv					603:612	organosolv	603:612	organosolv	603:612	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv) evaluated promoted chemical and morphological changes to the PCs.
33388571	3	61	dep	treatments	539:548	arg1	alkaline					584:591	alkaline	584:591	alkaline (AT)	584:596	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv) evaluated promoted chemical and morphological changes to the PCs.
33388571	3	61	dep	treatments	539:548	arg1	residue					569:575	alcohol-insoluble residue	551:575	alcohol-insoluble residue (AIR)	551:581	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv) evaluated promoted chemical and morphological changes to the PCs.
33388571	3	61	dep	treatments	539:548	arg1	AT					594:595	AT	594:595	AT	594:595	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv) evaluated promoted chemical and morphological changes to the PCs.
33388571	3	61	dep	treatments	539:548	arg1	AIR					578:580	AIR	578:580	AIR	578:580	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv) evaluated promoted chemical and morphological changes to the PCs.
33388571	5	62	theme	first	1046:1050	arg1	AT					1042:1043	AT	1042:1043	AT	1042:1043	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	5	62	theme	first	1046:1050	arg1	step					1062:1065	first bleaching step	1046:1065	first bleaching step	1046:1065	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	8	63	theme	Alkaline	1647:1654	arg1	alternative					1709:1719	an excellent alternative	1696:1719	an excellent alternative for the removal of non-cellulosic material	1696:1762	Alkaline treatment followed by H2O2 bleaching is an excellent alternative for the removal of non-cellulosic material and facilitates the isolation of cellulose.
33388571	8	63	theme	Alkaline	1647:1654	arg1	treatment					1656:1664	Alkaline treatment	1647:1664	Alkaline treatment followed by H2O2 bleaching	1647:1691	Alkaline treatment followed by H2O2 bleaching is an excellent alternative for the removal of non-cellulosic material and facilitates the isolation of cellulose.
33388571	6	64	from	decrease	1425:1432	arg1	content					1441:1447	the content	1437:1447	the content of hemicellulose, lignin and other soluble materials	1437:1500	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	1	65	theme	renewable	372:380	arg1	source					382:387	renewable source	372:387	renewable source for various industrial applications	372:423	Recently, the growing environmental concerns and economic demands have driven the need to develop effective solutions for the treatment of vegetal fibers to be used as renewable source for various industrial applications.
33388571	0	66	theme	composition	82:92	arg1	properties					168:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties	32:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials	32:201	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	1	67	theme	fibers	351:356	arg1	treatment					330:338	the treatment	326:338	the treatment of vegetal fibers	326:356	Recently, the growing environmental concerns and economic demands have driven the need to develop effective solutions for the treatment of vegetal fibers to be used as renewable source for various industrial applications.
33388571	6	68	theme	materials	1492:1500	arg1	content					1441:1447	the content	1437:1447	the content of hemicellulose, lignin and other soluble materials	1437:1500	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	5	69	theme	XRD	897:899	arg1	results					901:907	The XRD results	893:907	The XRD results	893:907	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	4	70	theme	chemical	871:878	arg1	composition					880:890	chemical composition	871:890	chemical composition	871:890	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	0	71	from	fiber	48:52	arg1	production					61:70	the production	57:70	the production	57:70	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	0	72	theme	crystalline	95:105	arg1	structure					107:115	crystalline structure	95:115	crystalline structure	95:115	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	6	73	theme	other	1478:1482	arg1	materials					1492:1500	other soluble materials	1478:1500	other soluble materials	1478:1500	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	4	74	theme	infrared	743:750	arg1	FTIR					766:769	FTIR	766:769	FTIR	766:769	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	4	74	theme	infrared	743:750	arg1	spectroscopy					752:763	Fourier-transform infrared spectroscopy	725:763	Fourier-transform infrared spectroscopy (FTIR)	725:770	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	5	75	theme	fresh	1213:1217	arg1	%					1227:1227	62.3%	1223:1227	62.3%	1223:1227	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	5	75	theme	fresh	1213:1217	arg1	PC					1219:1220	fresh PC	1213:1220	fresh PC (62.3%)	1213:1228	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	6	76	theme	lignin	1467:1472	arg1	content					1441:1447	the content	1437:1447	the content of hemicellulose, lignin and other soluble materials	1437:1500	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	8	77	theme	cellulose	1797:1805	arg1	isolation					1784:1792	the isolation	1780:1792	the isolation of cellulose	1780:1805	Alkaline treatment followed by H2O2 bleaching is an excellent alternative for the removal of non-cellulosic material and facilitates the isolation of cellulose.
33388571	9	78	theme	treatment	1907:1915	arg1	sequence					1895:1902	the sequence	1891:1902	the sequence of treatment of a methodology by chlorite-free	1891:1949	These results suggested that there is a potential to isolate cellulose from PC via the sequence of treatment of a methodology by chlorite-free.
33388571	4	79	theme	treated	691:697	arg1	PCs					699:701	Fresh and treated PCs	681:701	Fresh and treated PCs	681:701	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	0	80	theme	treatment	19:27	arg1	Effect					0:5	Effect	0:5	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.	0:202	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	6	81	theme	hemicellulose	1452:1464	arg1	content					1441:1447	the content	1437:1447	the content of hemicellulose, lignin and other soluble materials	1437:1500	Results from the thermal analysis revealed that thermal stability increased for the isolated cellulose, and the maximum degradation for (2B_KOH) is 350 °C. Chemical composition results showed a decrease in the content of hemicellulose, lignin and other soluble materials after alkaline treatment, suggesting high-quality 2B_KOH with 74.6% of cellulose.
33388571	2	82	theme	present	430:436	arg1	study					438:442	The present study	426:442	The present study	426:442	The present study aimed to explore pineapple crown fibers (PCs) as an alternative source of cellulose.
33388571	0	83	theme	pineapple	32:40	arg1	fiber					48:52	pineapple crown fiber	32:52	pineapple crown fiber in the production	32:70	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	5	84	theme	second	1099:1104	arg1	AT					1042:1043	AT	1042:1043	AT	1042:1043	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	5	84	theme	second	1099:1104	arg1	step					1116:1119	the second bleaching step	1095:1119	the second bleaching step	1095:1119	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	2	85	theme	crown	471:475	arg1	source					508:513	an alternative source	493:513	an alternative source of cellulose	493:526	The present study aimed to explore pineapple crown fibers (PCs) as an alternative source of cellulose.
33388571	2	85	theme	crown	471:475	arg1	PCs					485:487	PCs	485:487	PCs	485:487	The present study aimed to explore pineapple crown fibers (PCs) as an alternative source of cellulose.
33388571	2	85	theme	crown	471:475	arg1	fibers					477:482	pineapple crown fibers	461:482	pineapple crown fibers (PCs)	461:488	The present study aimed to explore pineapple crown fibers (PCs) as an alternative source of cellulose.
33388571	4	86	theme	X-ray	773:777	arg1	diffraction					779:789	X-ray diffraction	773:789	X-ray diffraction (XRD)	773:795	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	4	86	theme	X-ray	773:777	arg1	XRD					792:794	XRD	792:794	XRD	792:794	Fresh and treated PCs were characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), thermogravimetric analysis (TG), and chemical composition.
33388571	0	87	theme	fiber	48:52	arg1	properties					168:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties	32:177	pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials	32:201	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	5	88	theme	second	1068:1073	arg1	step					1085:1088	second bleaching step	1068:1088	second bleaching step	1068:1088	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	5	88	theme	second	1068:1073	arg1	AT					1042:1043	AT	1042:1043	AT	1042:1043	The XRD results showed that the Cellulose-I allomorph was not altered during extraction, and that the crystallinity index of the fibers treated with AT, first bleaching step, second bleaching step, and the second bleaching step followed by KOH treatment (2B_KOH) increased to 77.8; 83.2; 83.5 and 86% when compared with fresh PC (62.3%).
33388571	3	89	theme	chemical	634:641	arg1	changes					661:667	promoted chemical and morphological changes	625:667	promoted chemical and morphological changes to the PCs	625:678	The three treatments (alcohol-insoluble residue (AIR), alkaline (AT), and organosolv) evaluated promoted chemical and morphological changes to the PCs.
33388571	7	90	from	structure	1626:1634	arg1	fibers					1639:1644	fibers	1639:1644	fibers	1639:1644	SEM revealed changes in the morphological structure on fibers.
33388571	0	91	from	stability	126:134	arg1	production					61:70	the production	57:70	the production	57:70	Effect of chemical treatment of pineapple crown fiber in the production, chemical composition, crystalline structure, thermal stability and thermal degradation kinetic properties of cellulosic materials.
33388571	7	92	from	fibers	1639:1644	arg1	changes					1597:1603	changes	1597:1603	changes in the morphological structure on fibers	1597:1644	SEM revealed changes in the morphological structure on fibers.
34528980	2	0	theme	efficiency	338:347	arg1	test					349:352	The chiral separation efficiency test	316:352	The chiral separation efficiency test	316:352	The chiral separation efficiency test indicated that the nano-diameter CuLBH exhibited better selective potential towards (±)-1-(1-naphthyl)ethanol (NE) by providing more fully exposed recognition sites.
34528980	0	1	theme	enantioselective	92:107	arg1	capture					109:115	enhanced enantioselective capture	83:115	enhanced enantioselective capture	83:115	Decorated traditional cellulose with nanoscale chiral metal-organic frameworks for enhanced enantioselective capture.
34528980	3	2	theme	CuLBH-decorated	645:659	arg1	CC-CuLBH					699:706	the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH	631:706	the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH	631:706	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	2	3	dep	-1-	441:443	arg1	1-naphthyl					445:454	1-naphthyl	445:454	1-naphthyl	445:454	The chiral separation efficiency test indicated that the nano-diameter CuLBH exhibited better selective potential towards (±)-1-(1-naphthyl)ethanol (NE) by providing more fully exposed recognition sites.
34528980	1	4	theme	[Cu	194:196	arg1	synthesis					181:189	the size/morphology-controlled synthesis	150:189	the size/morphology-controlled synthesis of [Cu(L-mal)(bipy)·2H2O] (CuLBH)	150:223	Herein, a rapid approach toward the size/morphology-controlled synthesis of [Cu(L-mal)(bipy)·2H2O] (CuLBH) was developed by adjusting the concentrations of 2-methylimidazole (2-MI) and copper ions.
34528980	3	5	theme	pristine	832:839	arg1	CC					841:842	pristine CC	832:842	CC	841:842	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	3	6	theme	higher	792:797	arg1	enantioselectivity					799:816	much higher enantioselectivity	787:816	much higher enantioselectivity than those of pristine CC	787:842	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	3	7	theme	carboxylated	661:672	arg1	CC-CuLBH					699:706	the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH	631:706	the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH	631:706	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	3	8	theme	composite	689:697	arg1	CC-CuLBH					699:706	the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH	631:706	the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH	631:706	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	1	9	theme	rapid	128:132	arg1	approach					134:141	a rapid approach	126:141	a rapid approach toward the size/morphology-controlled synthesis of [Cu(L-mal)(bipy)·2H2O] (CuLBH)	126:223	Herein, a rapid approach toward the size/morphology-controlled synthesis of [Cu(L-mal)(bipy)·2H2O] (CuLBH) was developed by adjusting the concentrations of 2-methylimidazole (2-MI) and copper ions.
34528980	2	10	theme	-1-	441:443	arg1	NE					465:466	NE	465:466	NE	465:466	The chiral separation efficiency test indicated that the nano-diameter CuLBH exhibited better selective potential towards (±)-1-(1-naphthyl)ethanol (NE) by providing more fully exposed recognition sites.
34528980	2	10	theme	-1-	441:443	arg1	ethanol					456:462	(±)-1-(1-naphthyl)ethanol	438:462	(±)-1-(1-naphthyl)ethanol (NE)	438:467	The chiral separation efficiency test indicated that the nano-diameter CuLBH exhibited better selective potential towards (±)-1-(1-naphthyl)ethanol (NE) by providing more fully exposed recognition sites.
34528980	3	11	theme	CC	685:686	arg1	CC-CuLBH					699:706	the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH	631:706	the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH	631:706	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	3	12	theme	nano	853:856	arg1	CuLBH					858:862	nano CuLBH	853:862	nano CuLBH	853:862	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	2	13	theme	nano-diameter	373:385	arg1	CuLBH					387:391	the nano-diameter CuLBH	369:391	the nano-diameter CuLBH	369:391	The chiral separation efficiency test indicated that the nano-diameter CuLBH exhibited better selective potential towards (±)-1-(1-naphthyl)ethanol (NE) by providing more fully exposed recognition sites.
34528980	0	14	theme	traditional	10:20	arg1	cellulose					22:30	traditional cellulose	10:30	traditional cellulose	10:30	Decorated traditional cellulose with nanoscale chiral metal-organic frameworks for enhanced enantioselective capture.
34528980	1	15	theme	2-methylimidazole	274:290	arg1	concentrations					256:269	the concentrations	252:269	the concentrations of 2-methylimidazole (2-MI) and copper ions	252:313	Herein, a rapid approach toward the size/morphology-controlled synthesis of [Cu(L-mal)(bipy)·2H2O] (CuLBH) was developed by adjusting the concentrations of 2-methylimidazole (2-MI) and copper ions.
34528980	3	16	dep	solvent	753:759	arg1	the					749:751	the	749:751	the	749:751	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	2	17	theme	separation	327:336	arg1	test					349:352	The chiral separation efficiency test	316:352	The chiral separation efficiency test	316:352	The chiral separation efficiency test indicated that the nano-diameter CuLBH exhibited better selective potential towards (±)-1-(1-naphthyl)ethanol (NE) by providing more fully exposed recognition sites.
34528980	2	18	theme	selective	410:418	arg1	potential					420:428	better selective potential	403:428	better selective potential towards (±)-1-(1-naphthyl)ethanol (NE)	403:467	The chiral separation efficiency test indicated that the nano-diameter CuLBH exhibited better selective potential towards (±)-1-(1-naphthyl)ethanol (NE) by providing more fully exposed recognition sites.
34528980	0	19	theme	chiral	47:52	arg1	frameworks					68:77	nanoscale chiral metal-organic frameworks	37:77	nanoscale chiral metal-organic frameworks for enhanced enantioselective capture	37:115	Decorated traditional cellulose with nanoscale chiral metal-organic frameworks for enhanced enantioselective capture.
34528980	2	20	theme	recognition	501:511	arg1	sites					513:517	more fully exposed recognition sites	482:517	more fully exposed recognition sites	482:517	The chiral separation efficiency test indicated that the nano-diameter CuLBH exhibited better selective potential towards (±)-1-(1-naphthyl)ethanol (NE) by providing more fully exposed recognition sites.
34528980	3	21	theme	MOF	612:614	arg1	nanoparticles					616:628	MOF nanoparticles	612:628	MOF nanoparticles	612:628	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	0	22	theme	nanoscale	37:45	arg1	frameworks					68:77	nanoscale chiral metal-organic frameworks	37:77	nanoscale chiral metal-organic frameworks for enhanced enantioselective capture	37:115	Decorated traditional cellulose with nanoscale chiral metal-organic frameworks for enhanced enantioselective capture.
34528980	2	23	theme	exposed	493:499	arg1	sites					513:517	more fully exposed recognition sites	482:517	more fully exposed recognition sites	482:517	The chiral separation efficiency test indicated that the nano-diameter CuLBH exhibited better selective potential towards (±)-1-(1-naphthyl)ethanol (NE) by providing more fully exposed recognition sites.
34528980	1	24	dep	CuLBH	218:222	arg1	·2H2O					210:214	·2H2O	210:214	·2H2O	210:214	Herein, a rapid approach toward the size/morphology-controlled synthesis of [Cu(L-mal)(bipy)·2H2O] (CuLBH) was developed by adjusting the concentrations of 2-methylimidazole (2-MI) and copper ions.
34528980	1	24	dep	CuLBH	218:222	arg1	bipy					205:208	bipy	205:208	bipy	205:208	Herein, a rapid approach toward the size/morphology-controlled synthesis of [Cu(L-mal)(bipy)·2H2O] (CuLBH) was developed by adjusting the concentrations of 2-methylimidazole (2-MI) and copper ions.
34528980	2	25	theme	chiral	320:325	arg1	test					349:352	The chiral separation efficiency test	316:352	The chiral separation efficiency test	316:352	The chiral separation efficiency test indicated that the nano-diameter CuLBH exhibited better selective potential towards (±)-1-(1-naphthyl)ethanol (NE) by providing more fully exposed recognition sites.
34528980	0	26	theme	metal-organic	54:66	arg1	frameworks					68:77	nanoscale chiral metal-organic frameworks	37:77	nanoscale chiral metal-organic frameworks for enhanced enantioselective capture	37:115	Decorated traditional cellulose with nanoscale chiral metal-organic frameworks for enhanced enantioselective capture.
34528980	3	27	theme	cellulose	674:682	arg1	CC-CuLBH					699:706	the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH	631:706	the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH	631:706	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	1	28	theme	copper	303:308	arg1	ions					310:313	copper ions	303:313	copper ions	303:313	Herein, a rapid approach toward the size/morphology-controlled synthesis of [Cu(L-mal)(bipy)·2H2O] (CuLBH) was developed by adjusting the concentrations of 2-methylimidazole (2-MI) and copper ions.
34528980	3	29	theme	nanosized	635:643	arg1	CC-CuLBH					699:706	the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH	631:706	the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH	631:706	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	3	30	theme	Cu2+	765:768	arg1	ratio					740:744	the ratio	736:744	the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH	736:862	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	3	31	theme	nanoparticles	616:628	arg1	aggregation					597:607	the aggregation	593:607	the aggregation of MOF nanoparticles	593:628	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	0	32	theme	enhanced	83:90	arg1	capture					109:115	enhanced enantioselective capture	83:115	enhanced enantioselective capture	83:115	Decorated traditional cellulose with nanoscale chiral metal-organic frameworks for enhanced enantioselective capture.
34528980	3	33	theme	NE	568:569	arg1	enantiomers					571:581	NE enantiomers	568:581	NE enantiomers	568:581	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	1	34	theme	size/morphology-controlled	154:179	arg1	synthesis					181:189	the size/morphology-controlled synthesis	150:189	the size/morphology-controlled synthesis of [Cu(L-mal)(bipy)·2H2O] (CuLBH)	150:223	Herein, a rapid approach toward the size/morphology-controlled synthesis of [Cu(L-mal)(bipy)·2H2O] (CuLBH) was developed by adjusting the concentrations of 2-methylimidazole (2-MI) and copper ions.
34528980	3	35	theme	solvent	753:759	arg1	ratio					740:744	the ratio	736:744	the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH	736:862	In order to further improve the selectivity for NE enantiomers and avoid the aggregation of MOF nanoparticles, the nanosized CuLBH-decorated carboxylated cellulose (CC) composite CC-CuLBH was designed by controlling the ratio of the solvent and Cu2+, which exhibited much higher enantioselectivity than those of pristine CC and even nano CuLBH.
34528980	1	36	theme	ions	310:313	arg1	concentrations					256:269	the concentrations	252:269	the concentrations of 2-methylimidazole (2-MI) and copper ions	252:313	Herein, a rapid approach toward the size/morphology-controlled synthesis of [Cu(L-mal)(bipy)·2H2O] (CuLBH) was developed by adjusting the concentrations of 2-methylimidazole (2-MI) and copper ions.
31981661	4	0	from	45 °C	805:809	arg1	153.8					767:771	153.8	767:771	153.8	767:771	The kinetic data for the adsorption of CR followed the pseudo-second-order model and the Langmuir maximum adsorption capacity for CR at pH 7.0 were found to be 153.8, 200 and 250 mg/g at 25, 35 and 45 °C correspondingly.
31981661	1	1	theme	Gum	135:137	arg1	Gg					147:148	Gg	147:148	Gg	147:148	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	1	1	theme	Gum	135:137	arg1	ghatti					139:144	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer	135:188	ghatti	139:144	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	0	2	theme	gum	63:65	arg1	ghatti					67:72	gum ghatti	63:72	gum ghatti	63:72	Removal of Congo red from aqueous solution by adsorption using gum ghatti and acrylamide graft copolymer coated with zero valent iron.
31981661	2	3	dep	/ZVI	336:339	arg1	[poly					322:326	Prepared composite, [poly (Gg-AAm)/ZVI]	302:340	[poly	322:326	Prepared composite, [poly (Gg-AAm)/ZVI] was characterized by FESEM, TEM, BET, FTIR and XRD.
31981661	1	4	theme	ghatti	139:144	arg1	[poly					190:194	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly	135:194	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI)	135:237	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	1	4	theme	ghatti	139:144	arg1	Gg-AAm					197:202	Gg-AAm	197:202	Gg-AAm	197:202	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	3	5	dep	such	496:499	arg1	as					501:502	as	501:502	as	501:502	CR adsorption from water using [poly (Gg-AAm)/ZVI] was investigated and several parameters discussed, such as solution pH, contact time, dosage and temperature to find out removal efficiency of polymer composite.
31981661	0	6	theme	acrylamide	78:87	arg1	copolymer					95:103	acrylamide graft copolymer	78:103	acrylamide graft copolymer	78:103	Removal of Congo red from aqueous solution by adsorption using gum ghatti and acrylamide graft copolymer coated with zero valent iron.
31981661	5	7	theme	thermodynamic	927:939	arg1	energy					971:976	Gibbs free energy	960:976	Gibbs free energy (ΔG0)	960:982	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	5	7	theme	thermodynamic	927:939	arg1	parameters					941:950	thermodynamic parameters	927:950	thermodynamic parameters	927:950	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	4	8	theme	Langmuir	696:703	arg1	adsorption					713:722	the Langmuir maximum adsorption	692:722	the Langmuir maximum adsorption capacity for CR at pH 7.0	692:748	The kinetic data for the adsorption of CR followed the pseudo-second-order model and the Langmuir maximum adsorption capacity for CR at pH 7.0 were found to be 153.8, 200 and 250 mg/g at 25, 35 and 45 °C correspondingly.
31981661	5	9	theme	enthalpy	985:992	arg1	changes					1018:1024	enthalpy (ΔH0) and entropy (ΔS0) changes	985:1024	enthalpy (ΔH0) and entropy (ΔS0) changes	985:1024	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	5	10	theme	entropy	1004:1010	arg1	changes					1018:1024	enthalpy (ΔH0) and entropy (ΔS0) changes	985:1024	enthalpy (ΔH0) and entropy (ΔS0) changes	985:1024	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	5	11	dep	showed	1026:1031	arg1	endothermic					1109:1119	endothermic	1109:1119	endothermic	1109:1119	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	5	11	dep	showed	1026:1031	arg1	spontaneous					1093:1103	spontaneous	1093:1103	spontaneous	1093:1103	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	5	11	dep	showed	1026:1031	arg1	feasible					1083:1090	feasible	1083:1090	feasible	1083:1090	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	3	12	theme	CR	394:395	arg1	adsorption					397:406	CR adsorption	394:406	CR adsorption from water using [poly (Gg-AAm)/ZVI]	394:443	CR adsorption from water using [poly (Gg-AAm)/ZVI] was investigated and several parameters discussed, such as solution pH, contact time, dosage and temperature to find out removal efficiency of polymer composite.
31981661	0	13	from	solution	34:41	arg1	Removal					0:6	Removal	0:6	Removal of Congo red from aqueous solution by adsorption using gum ghatti and acrylamide graft copolymer	0:103	Removal of Congo red from aqueous solution by adsorption using gum ghatti and acrylamide graft copolymer coated with zero valent iron.
31981661	0	14	theme	graft	89:93	arg1	copolymer					95:103	acrylamide graft copolymer	78:103	acrylamide graft copolymer	78:103	Removal of Congo red from aqueous solution by adsorption using gum ghatti and acrylamide graft copolymer coated with zero valent iron.
31981661	4	15	theme	CR	646:647	arg1	adsorption					632:641	the adsorption	628:641	the adsorption of CR	628:647	The kinetic data for the adsorption of CR followed the pseudo-second-order model and the Langmuir maximum adsorption capacity for CR at pH 7.0 were found to be 153.8, 200 and 250 mg/g at 25, 35 and 45 °C correspondingly.
31981661	4	16	theme	pseudo-second-order	662:680	arg1	model					682:686	the pseudo-second-order model	658:686	the pseudo-second-order model	658:686	The kinetic data for the adsorption of CR followed the pseudo-second-order model and the Langmuir maximum adsorption capacity for CR at pH 7.0 were found to be 153.8, 200 and 250 mg/g at 25, 35 and 45 °C correspondingly.
31981661	2	17	theme	Gg-AAm	329:334	arg1	/ZVI					336:339	Prepared composite, [poly (Gg-AAm)/ZVI]	302:340	/ZVI	336:339	Prepared composite, [poly (Gg-AAm)/ZVI] was characterized by FESEM, TEM, BET, FTIR and XRD.
31981661	5	18	theme	free	966:969	arg1	energy					971:976	Gibbs free energy	960:976	Gibbs free energy (ΔG0)	960:982	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	5	18	theme	free	966:969	arg1	ΔG0					979:981	ΔG0	979:981	ΔG0	979:981	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	5	19	theme	Desorption	828:837	arg1	studies					839:845	Desorption studies	828:845	Desorption studies	828:845	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	5	20	theme	CR	1051:1052	arg1	adsorption					1037:1046	the adsorption	1033:1046	the adsorption of CR onto [poly (Gg-AAm)/ZVI]	1033:1077	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	0	21	theme	red	17:19	arg1	Removal					0:6	Removal	0:6	Removal of Congo red from aqueous solution by adsorption using gum ghatti and acrylamide graft copolymer	0:103	Removal of Congo red from aqueous solution by adsorption using gum ghatti and acrylamide graft copolymer coated with zero valent iron.
31981661	3	22	theme	removal	566:572	arg1	efficiency					574:583	removal efficiency	566:583	removal efficiency of polymer composite	566:604	CR adsorption from water using [poly (Gg-AAm)/ZVI] was investigated and several parameters discussed, such as solution pH, contact time, dosage and temperature to find out removal efficiency of polymer composite.
31981661	1	23	theme	acrylamide	155:164	arg1	AAm					167:169	AAm	167:169	AAm	167:169	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	1	23	theme	acrylamide	155:164	arg1	copolymer					180:188	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer	135:188	copolymer	180:188	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	1	24	theme	valent	221:226	arg1	ZVI					234:236	ZVI	234:236	ZVI	234:236	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	1	24	theme	valent	221:226	arg1	iron					228:231	zero valent iron	216:231	zero valent iron (ZVI)	216:237	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	5	25	theme	prepared	861:868	arg1	composite					870:878	prepared composite	861:878	prepared composite	861:878	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	5	26	theme	[poly	1059:1063	arg1	Gg-AAm					1066:1071	[poly (Gg-AAm)/ZVI]	1059:1077	[poly (Gg-AAm)/ZVI]	1059:1077	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	2	27	theme	composite	311:319	arg1	/ZVI					336:339	Prepared composite, [poly (Gg-AAm)/ZVI]	302:340	/ZVI	336:339	Prepared composite, [poly (Gg-AAm)/ZVI] was characterized by FESEM, TEM, BET, FTIR and XRD.
31981661	0	28	theme	aqueous	26:32	arg1	solution					34:41	aqueous solution	26:41	aqueous solution	26:41	Removal of Congo red from aqueous solution by adsorption using gum ghatti and acrylamide graft copolymer coated with zero valent iron.
31981661	0	29	theme	valent	122:127	arg1	iron					129:132	zero valent iron	117:132	zero valent iron	117:132	Removal of Congo red from aqueous solution by adsorption using gum ghatti and acrylamide graft copolymer coated with zero valent iron.
31981661	4	30	from	pH 7.0	743:748	arg1	capacity					724:731	the Langmuir maximum adsorption capacity	692:731	the Langmuir maximum adsorption capacity for CR at pH 7.0	692:748	The kinetic data for the adsorption of CR followed the pseudo-second-order model and the Langmuir maximum adsorption capacity for CR at pH 7.0 were found to be 153.8, 200 and 250 mg/g at 25, 35 and 45 °C correspondingly.
31981661	3	31	theme	Gg-AAm	432:437	arg1	/ZVI					439:442	[poly (Gg-AAm)/ZVI]	425:443	[poly (Gg-AAm)/ZVI]	425:443	CR adsorption from water using [poly (Gg-AAm)/ZVI] was investigated and several parameters discussed, such as solution pH, contact time, dosage and temperature to find out removal efficiency of polymer composite.
31981661	2	32	theme	Prepared	302:309	arg1	/ZVI					336:339	Prepared composite, [poly (Gg-AAm)/ZVI]	302:340	/ZVI	336:339	Prepared composite, [poly (Gg-AAm)/ZVI] was characterized by FESEM, TEM, BET, FTIR and XRD.
31981661	3	33	theme	polymer	588:594	arg1	composite					596:604	polymer composite	588:604	polymer composite	588:604	CR adsorption from water using [poly (Gg-AAm)/ZVI] was investigated and several parameters discussed, such as solution pH, contact time, dosage and temperature to find out removal efficiency of polymer composite.
31981661	0	34	theme	zero	117:120	arg1	valent					122:127	valent	122:127	valent	122:127	Removal of Congo red from aqueous solution by adsorption using gum ghatti and acrylamide graft copolymer coated with zero valent iron.
31981661	1	35	theme	waste	289:293	arg1	water					295:299	waste water	289:299	waste water	289:299	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	3	36	theme	composite	596:604	arg1	efficiency					574:583	removal efficiency	566:583	removal efficiency of polymer composite	566:604	CR adsorption from water using [poly (Gg-AAm)/ZVI] was investigated and several parameters discussed, such as solution pH, contact time, dosage and temperature to find out removal efficiency of polymer composite.
31981661	4	37	theme	adsorption	713:722	arg1	capacity					724:731	the Langmuir maximum adsorption capacity	692:731	the Langmuir maximum adsorption capacity for CR at pH 7.0	692:748	The kinetic data for the adsorption of CR followed the pseudo-second-order model and the Langmuir maximum adsorption capacity for CR at pH 7.0 were found to be 153.8, 200 and 250 mg/g at 25, 35 and 45 °C correspondingly.
31981661	1	38	theme	zero	216:219	arg1	valent					221:226	valent	221:226	valent	221:226	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	3	39	theme	[poly	425:429	arg1	/ZVI					439:442	[poly (Gg-AAm)/ZVI]	425:443	[poly (Gg-AAm)/ZVI]	425:443	CR adsorption from water using [poly (Gg-AAm)/ZVI] was investigated and several parameters discussed, such as solution pH, contact time, dosage and temperature to find out removal efficiency of polymer composite.
31981661	4	40	from	25	794:795	arg1	153.8					767:771	153.8	767:771	153.8	767:771	The kinetic data for the adsorption of CR followed the pseudo-second-order model and the Langmuir maximum adsorption capacity for CR at pH 7.0 were found to be 153.8, 200 and 250 mg/g at 25, 35 and 45 °C correspondingly.
31981661	4	41	theme	maximum	705:711	arg1	adsorption					713:722	the Langmuir maximum adsorption	692:722	the Langmuir maximum adsorption capacity for CR at pH 7.0	692:748	The kinetic data for the adsorption of CR followed the pseudo-second-order model and the Langmuir maximum adsorption capacity for CR at pH 7.0 were found to be 153.8, 200 and 250 mg/g at 25, 35 and 45 °C correspondingly.
31981661	3	42	theme	several	466:472	arg1	parameters					474:483	several parameters	466:483	several parameters discussed	466:493	CR adsorption from water using [poly (Gg-AAm)/ZVI] was investigated and several parameters discussed, such as solution pH, contact time, dosage and temperature to find out removal efficiency of polymer composite.
31981661	5	43	theme	Gibbs	960:964	arg1	energy					971:976	Gibbs free energy	960:976	Gibbs free energy (ΔG0)	960:982	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	5	43	theme	Gibbs	960:964	arg1	ΔG0					979:981	ΔG0	979:981	ΔG0	979:981	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	3	44	theme	solution	504:511	arg1	pH					513:514	solution pH	504:514	solution pH	504:514	CR adsorption from water using [poly (Gg-AAm)/ZVI] was investigated and several parameters discussed, such as solution pH, contact time, dosage and temperature to find out removal efficiency of polymer composite.
31981661	5	45	dep	cycles	904:909	arg1	up					892:893	up	892:893	up	892:893	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
31981661	1	46	theme	grafted	172:178	arg1	AAm					167:169	AAm	167:169	AAm	167:169	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	1	46	theme	grafted	172:178	arg1	copolymer					180:188	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer	135:188	copolymer	180:188	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	3	47	from	water	413:417	arg1	adsorption					397:406	CR adsorption	394:406	CR adsorption from water using [poly (Gg-AAm)/ZVI]	394:443	CR adsorption from water using [poly (Gg-AAm)/ZVI] was investigated and several parameters discussed, such as solution pH, contact time, dosage and temperature to find out removal efficiency of polymer composite.
31981661	1	48	theme	copolymer	180:188	arg1	[poly					190:194	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly	135:194	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI)	135:237	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	1	48	theme	copolymer	180:188	arg1	Gg-AAm					197:202	Gg-AAm	197:202	Gg-AAm	197:202	Gum ghatti (Gg) and acrylamide (AAm) grafted copolymer [poly (Gg-AAm)] coated by zero valent iron (ZVI) was developed to remove toxic Congo red (CR) from waste water.
31981661	3	49	theme	contact	517:523	arg1	time					525:528	contact time	517:528	contact time	517:528	CR adsorption from water using [poly (Gg-AAm)/ZVI] was investigated and several parameters discussed, such as solution pH, contact time, dosage and temperature to find out removal efficiency of polymer composite.
31981661	4	50	theme	kinetic	611:617	arg1	data					619:622	The kinetic data	607:622	The kinetic data for the adsorption of CR	607:647	The kinetic data for the adsorption of CR followed the pseudo-second-order model and the Langmuir maximum adsorption capacity for CR at pH 7.0 were found to be 153.8, 200 and 250 mg/g at 25, 35 and 45 °C correspondingly.
31981661	5	51	used	used	887:890	arg2	composite					870:878	prepared composite	861:878	prepared composite	861:878	Desorption studies revealed that prepared composite can be used up to three cycles efficiently and thermodynamic parameters such as Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) changes showed the adsorption of CR onto [poly (Gg-AAm)/ZVI] was feasible, spontaneous and endothermic.
34885676	4	0	theme	retention	698:706	arg1	faction					708:714	retention faction	698:714	retention faction	698:714	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	6	1	theme	classical	1201:1209	arg1	technique					1252:1260	a classical dispersive liquid-liquid microextraction technique	1199:1260	a classical dispersive liquid-liquid microextraction technique preceded by protein precipitation	1199:1294	The method was then applied to milk samples, which were pretreated using a classical dispersive liquid-liquid microextraction technique preceded by protein precipitation.
34885676	6	2	theme	dispersive	1211:1220	arg1	technique					1252:1260	a classical dispersive liquid-liquid microextraction technique	1199:1260	a classical dispersive liquid-liquid microextraction technique preceded by protein precipitation	1199:1294	The method was then applied to milk samples, which were pretreated using a classical dispersive liquid-liquid microextraction technique preceded by protein precipitation.
34885676	1	3	theme	chiral	171:176	arg1	separation					178:187	chiral separation	171:187	chiral separation	171:187	A novel chromatographic application in chiral separation by using the nano-LC technique is here reported.
34885676	0	4	theme	Drugs	117:121	arg1	Analysis					94:101	the Analysis	90:101	the Analysis of Antifungal Drugs in Milk	90:129	Chiral Nano-Liquid Chromatography and Dispersive Liquid-Liquid Microextraction Applied to the Analysis of Antifungal Drugs in Milk.
34885676	7	5	theme	FDA	1379:1381	arg1	guidelines					1383:1392	the main FDA guidelines	1370:1392	the main FDA guidelines for bioanalytical methods	1370:1418	Finally, the DLLME-nano-LC-UV method was validated in a matrix following the main FDA guidelines for bioanalytical methods.
34885676	4	6	theme	peak	757:760	arg1	shape					762:766	peak shape	757:766	peak shape	757:766	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	6	7	theme	milk	1157:1160	arg1	samples					1162:1168	milk samples	1157:1168	milk samples	1157:1168	The method was then applied to milk samples, which were pretreated using a classical dispersive liquid-liquid microextraction technique preceded by protein precipitation.
34885676	0	8	theme	Antifungal	106:115	arg1	Drugs					117:121	Antifungal Drugs	106:121	Antifungal Drugs in Milk	106:129	Chiral Nano-Liquid Chromatography and Dispersive Liquid-Liquid Microextraction Applied to the Analysis of Antifungal Drugs in Milk.
34885676	1	9	from	application	156:166	arg1	separation					178:187	chiral separation	171:187	chiral separation	171:187	A novel chromatographic application in chiral separation by using the nano-LC technique is here reported.
34885676	3	10	theme	experimental	503:514	arg1	conditions					516:525	the experimental conditions	499:525	the experimental conditions	499:525	The mobile phase composition and the experimental conditions were optimized in order to find the optimum chiral separation for some selected racemic mixtures of imidazole and triazole derivatives.
34885676	4	11	theme	peak	736:739	arg1	efficiency					741:750	peak efficiency	736:750	peak efficiency	736:750	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	12	theme	water	826:830	arg1	content					832:838	water content	826:838	water content	826:838	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	12	theme	water	826:830	arg1	pH					822:823	pH	822:823	pH	822:823	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	13	theme	mobile	808:813	arg1	phase					815:819	the mobile phase	804:819	the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition)	804:941	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	14	theme	dilution	921:928	arg1	composition					930:940	solvent dilution composition	913:940	solvent dilution composition	913:940	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	14	theme	dilution	921:928	arg1	pH					822:823	pH	822:823	pH	822:823	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	0	15	theme	Chiral	0:5	arg1	Chromatography					19:32	Chiral Nano-Liquid Chromatography	0:32	Chiral Nano-Liquid Chromatography	0:32	Chiral Nano-Liquid Chromatography and Dispersive Liquid-Liquid Microextraction Applied to the Analysis of Antifungal Drugs in Milk.
34885676	4	16	theme	important	668:676	arg1	efficiency					741:750	peak efficiency	736:750	peak efficiency	736:750	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	16	theme	important	668:676	arg1	faction					708:714	retention faction	698:714	retention faction	698:714	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	16	theme	important	668:676	arg1	parameters					678:687	Some important parameters	663:687	Some important parameters	663:687	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	16	theme	important	668:676	arg1	shape					762:766	peak shape	757:766	peak shape	757:766	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	16	theme	important	668:676	arg1	function					792:799	a function	790:799	a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition)	790:941	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	16	theme	important	668:676	arg1	enantioresolution					717:733	enantioresolution	717:733	enantioresolution	717:733	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	0	17	theme	Nano-Liquid	7:17	arg1	Chromatography					19:32	Chiral Nano-Liquid Chromatography	0:32	Chiral Nano-Liquid Chromatography	0:32	Chiral Nano-Liquid Chromatography and Dispersive Liquid-Liquid Microextraction Applied to the Analysis of Antifungal Drugs in Milk.
34885676	7	18	theme	bioanalytical	1398:1410	arg1	methods					1412:1418	bioanalytical methods	1398:1418	bioanalytical methods	1398:1418	Finally, the DLLME-nano-LC-UV method was validated in a matrix following the main FDA guidelines for bioanalytical methods.
34885676	2	19	theme	fused-silica	318:329	arg1	capillary					331:339	a 75 µm I.D. fused-silica capillary	305:339	a 75 µm I.D. fused-silica capillary	305:339	The chiral recognition of 12 antifungal drugs was obtained through a 75 µm I.D. fused-silica capillary, which was packed with a CSP-cellulose 3,5-dichlorophenylcarbamate (CDCPC), by means of a lab-made slurry packing procedure.
34885676	2	20	theme	slurry	440:445	arg1	procedure					455:463	a lab-made slurry packing procedure	429:463	a lab-made slurry packing procedure	429:463	The chiral recognition of 12 antifungal drugs was obtained through a 75 µm I.D. fused-silica capillary, which was packed with a CSP-cellulose 3,5-dichlorophenylcarbamate (CDCPC), by means of a lab-made slurry packing procedure.
34885676	2	21	theme	I.D.	313:316	arg1	capillary					331:339	a 75 µm I.D. fused-silica capillary	305:339	a 75 µm I.D. fused-silica capillary	305:339	The chiral recognition of 12 antifungal drugs was obtained through a 75 µm I.D. fused-silica capillary, which was packed with a CSP-cellulose 3,5-dichlorophenylcarbamate (CDCPC), by means of a lab-made slurry packing procedure.
34885676	1	22	theme	nano-LC	202:208	arg1	technique					210:218	the nano-LC technique	198:218	the nano-LC technique	198:218	A novel chromatographic application in chiral separation by using the nano-LC technique is here reported.
34885676	2	23	theme	lab-made	431:438	arg1	procedure					455:463	a lab-made slurry packing procedure	429:463	a lab-made slurry packing procedure	429:463	The chiral recognition of 12 antifungal drugs was obtained through a 75 µm I.D. fused-silica capillary, which was packed with a CSP-cellulose 3,5-dichlorophenylcarbamate (CDCPC), by means of a lab-made slurry packing procedure.
34885676	4	24	theme	organic	891:897	arg1	modifier					899:906	the organic modifier	887:906	the organic modifier	887:906	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	2	25	theme	µm	310:311	arg1	capillary					331:339	a 75 µm I.D. fused-silica capillary	305:339	a 75 µm I.D. fused-silica capillary	305:339	The chiral recognition of 12 antifungal drugs was obtained through a 75 µm I.D. fused-silica capillary, which was packed with a CSP-cellulose 3,5-dichlorophenylcarbamate (CDCPC), by means of a lab-made slurry packing procedure.
34885676	4	26	theme	phase	815:819	arg1	efficiency					741:750	peak efficiency	736:750	peak efficiency	736:750	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	26	theme	phase	815:819	arg1	faction					708:714	retention faction	698:714	retention faction	698:714	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	26	theme	phase	815:819	arg1	parameters					678:687	Some important parameters	663:687	Some important parameters	663:687	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	26	theme	phase	815:819	arg1	shape					762:766	peak shape	757:766	peak shape	757:766	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	26	theme	phase	815:819	arg1	function					792:799	a function	790:799	a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition)	790:941	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	26	theme	phase	815:819	arg1	enantioresolution					717:733	enantioresolution	717:733	enantioresolution	717:733	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	6	27	theme	protein	1274:1280	arg1	precipitation					1282:1294	protein precipitation	1274:1294	protein precipitation	1274:1294	The method was then applied to milk samples, which were pretreated using a classical dispersive liquid-liquid microextraction technique preceded by protein precipitation.
34885676	5	28	theme	nL	1011:1012	arg1	min-1					1014:1018	approximately 400 nL min-1	993:1018	approximately 400 nL min-1	993:1018	Within one run lasting 25 min, at a flow rate of approximately 400 nL min-1, eight couples of enantiomers were baseline-resolved and four of them were separated in less than 25 min.
34885676	3	29	theme	optimum	563:569	arg1	separation					578:587	the optimum chiral separation	559:587	the optimum chiral separation	559:587	The mobile phase composition and the experimental conditions were optimized in order to find the optimum chiral separation for some selected racemic mixtures of imidazole and triazole derivatives.
34885676	3	30	theme	mobile	470:475	arg1	composition					483:493	The mobile phase composition	466:493	The mobile phase composition	466:493	The mobile phase composition and the experimental conditions were optimized in order to find the optimum chiral separation for some selected racemic mixtures of imidazole and triazole derivatives.
34885676	0	31	theme	Liquid-Liquid	49:61	arg1	Microextraction					63:77	Dispersive Liquid-Liquid Microextraction	38:77	Dispersive Liquid-Liquid Microextraction	38:77	Chiral Nano-Liquid Chromatography and Dispersive Liquid-Liquid Microextraction Applied to the Analysis of Antifungal Drugs in Milk.
34885676	0	32	from	Analysis	94:101	arg1	Milk					126:129	Milk	126:129	Milk	126:129	Chiral Nano-Liquid Chromatography and Dispersive Liquid-Liquid Microextraction Applied to the Analysis of Antifungal Drugs in Milk.
34885676	3	33	theme	selected	598:605	arg1	mixtures					615:622	some selected racemic mixtures	593:622	some selected racemic mixtures of imidazole and triazole derivatives	593:660	The mobile phase composition and the experimental conditions were optimized in order to find the optimum chiral separation for some selected racemic mixtures of imidazole and triazole derivatives.
34885676	4	34	dep	phase	815:819	arg1	content					832:838	water content	826:838	water content	826:838	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	34	dep	phase	815:819	arg1	composition					930:940	solvent dilution composition	913:940	solvent dilution composition	913:940	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	34	dep	phase	815:819	arg1	type					841:844	type	841:844	type	841:844	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	34	dep	phase	815:819	arg1	pH					822:823	pH	822:823	pH	822:823	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	0	35	theme	Dispersive	38:47	arg1	Microextraction					63:77	Dispersive Liquid-Liquid Microextraction	38:77	Dispersive Liquid-Liquid Microextraction	38:77	Chiral Nano-Liquid Chromatography and Dispersive Liquid-Liquid Microextraction Applied to the Analysis of Antifungal Drugs in Milk.
34885676	5	36	theme	them	1085:1088	arg1	them					1085:1088	them	1085:1088	them	1085:1088	Within one run lasting 25 min, at a flow rate of approximately 400 nL min-1, eight couples of enantiomers were baseline-resolved and four of them were separated in less than 25 min.
34885676	5	36	theme	them	1085:1088	arg1	four					1077:1080	four	1077:1080	four	1077:1080	Within one run lasting 25 min, at a flow rate of approximately 400 nL min-1, eight couples of enantiomers were baseline-resolved and four of them were separated in less than 25 min.
34885676	4	37	theme	modifier	899:906	arg1	content					832:838	water content	826:838	water content	826:838	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	37	theme	modifier	899:906	arg1	composition					930:940	solvent dilution composition	913:940	solvent dilution composition	913:940	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	37	theme	modifier	899:906	arg1	concentration					850:862	concentration	850:862	concentration	850:862	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	37	theme	modifier	899:906	arg1	type					841:844	type	841:844	type	841:844	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	37	theme	modifier	899:906	arg1	pH					822:823	pH	822:823	pH	822:823	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	3	38	theme	triazole	641:648	arg1	derivatives					650:660	imidazole and triazole derivatives	627:660	imidazole and triazole derivatives	627:660	The mobile phase composition and the experimental conditions were optimized in order to find the optimum chiral separation for some selected racemic mixtures of imidazole and triazole derivatives.
34885676	2	39	theme	chiral	242:247	arg1	recognition					249:259	The chiral recognition	238:259	The chiral recognition of 12 antifungal drugs	238:282	The chiral recognition of 12 antifungal drugs was obtained through a 75 µm I.D. fused-silica capillary, which was packed with a CSP-cellulose 3,5-dichlorophenylcarbamate (CDCPC), by means of a lab-made slurry packing procedure.
34885676	4	40	theme	solvent	913:919	arg1	composition					930:940	solvent dilution composition	913:940	solvent dilution composition	913:940	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	40	theme	solvent	913:919	arg1	pH					822:823	pH	822:823	pH	822:823	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	3	41	theme	derivatives	650:660	arg1	mixtures					615:622	some selected racemic mixtures	593:622	some selected racemic mixtures of imidazole and triazole derivatives	593:660	The mobile phase composition and the experimental conditions were optimized in order to find the optimum chiral separation for some selected racemic mixtures of imidazole and triazole derivatives.
34885676	7	42	theme	DLLME-nano-LC-UV	1310:1325	arg1	method					1327:1332	the DLLME-nano-LC-UV method	1306:1332	the DLLME-nano-LC-UV method	1306:1332	Finally, the DLLME-nano-LC-UV method was validated in a matrix following the main FDA guidelines for bioanalytical methods.
34885676	6	43	theme	microextraction	1236:1250	arg1	technique					1252:1260	a classical dispersive liquid-liquid microextraction technique	1199:1260	a classical dispersive liquid-liquid microextraction technique preceded by protein precipitation	1199:1294	The method was then applied to milk samples, which were pretreated using a classical dispersive liquid-liquid microextraction technique preceded by protein precipitation.
34885676	0	44	from	Milk	126:129	arg1	Analysis					94:101	the Analysis	90:101	the Analysis of Antifungal Drugs in Milk	90:129	Chiral Nano-Liquid Chromatography and Dispersive Liquid-Liquid Microextraction Applied to the Analysis of Antifungal Drugs in Milk.
34885676	5	45	theme	flow	980:983	arg1	rate					985:988	a flow rate	978:988	a flow rate of approximately 400 nL min-1	978:1018	Within one run lasting 25 min, at a flow rate of approximately 400 nL min-1, eight couples of enantiomers were baseline-resolved and four of them were separated in less than 25 min.
34885676	7	46	theme	main	1374:1377	arg1	guidelines					1383:1392	the main FDA guidelines	1370:1392	the main FDA guidelines for bioanalytical methods	1370:1418	Finally, the DLLME-nano-LC-UV method was validated in a matrix following the main FDA guidelines for bioanalytical methods.
34885676	3	47	theme	chiral	571:576	arg1	separation					578:587	the optimum chiral separation	559:587	the optimum chiral separation	559:587	The mobile phase composition and the experimental conditions were optimized in order to find the optimum chiral separation for some selected racemic mixtures of imidazole and triazole derivatives.
34885676	6	48	theme	liquid-liquid	1222:1234	arg1	technique					1252:1260	a classical dispersive liquid-liquid microextraction technique	1199:1260	a classical dispersive liquid-liquid microextraction technique preceded by protein precipitation	1199:1294	The method was then applied to milk samples, which were pretreated using a classical dispersive liquid-liquid microextraction technique preceded by protein precipitation.
34885676	3	49	theme	imidazole	627:635	arg1	derivatives					650:660	imidazole and triazole derivatives	627:660	imidazole and triazole derivatives	627:660	The mobile phase composition and the experimental conditions were optimized in order to find the optimum chiral separation for some selected racemic mixtures of imidazole and triazole derivatives.
34885676	2	50	theme	drugs	278:282	arg1	recognition					249:259	The chiral recognition	238:259	The chiral recognition of 12 antifungal drugs	238:282	The chiral recognition of 12 antifungal drugs was obtained through a 75 µm I.D. fused-silica capillary, which was packed with a CSP-cellulose 3,5-dichlorophenylcarbamate (CDCPC), by means of a lab-made slurry packing procedure.
34885676	3	51	theme	racemic	607:613	arg1	mixtures					615:622	some selected racemic mixtures	593:622	some selected racemic mixtures of imidazole and triazole derivatives	593:660	The mobile phase composition and the experimental conditions were optimized in order to find the optimum chiral separation for some selected racemic mixtures of imidazole and triazole derivatives.
34885676	1	52	theme	novel	134:138	arg1	application					156:166	A novel chromatographic application	132:166	A novel chromatographic application in chiral separation by using the nano-LC technique	132:218	A novel chromatographic application in chiral separation by using the nano-LC technique is here reported.
34885676	4	53	theme	buffer	876:881	arg1	content					832:838	water content	826:838	water content	826:838	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	53	theme	buffer	876:881	arg1	composition					930:940	solvent dilution composition	913:940	solvent dilution composition	913:940	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	53	theme	buffer	876:881	arg1	concentration					850:862	concentration	850:862	concentration	850:862	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	53	theme	buffer	876:881	arg1	type					841:844	type	841:844	type	841:844	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	4	53	theme	buffer	876:881	arg1	pH					822:823	pH	822:823	pH	822:823	Some important parameters, such as retention faction, enantioresolution, peak efficiency, and peak shape, were investigated as a function of the mobile phase (pH, water content, type and concentration of both the buffer and the organic modifier, and solvent dilution composition).
34885676	0	54	from	Drugs	117:121	arg1	Milk					126:129	Milk	126:129	Milk	126:129	Chiral Nano-Liquid Chromatography and Dispersive Liquid-Liquid Microextraction Applied to the Analysis of Antifungal Drugs in Milk.
34885676	2	55	theme	antifungal	267:276	arg1	drugs					278:282	12 antifungal drugs	264:282	12 antifungal drugs	264:282	The chiral recognition of 12 antifungal drugs was obtained through a 75 µm I.D. fused-silica capillary, which was packed with a CSP-cellulose 3,5-dichlorophenylcarbamate (CDCPC), by means of a lab-made slurry packing procedure.
34885676	5	56	theme	min-1	1014:1018	arg1	rate					985:988	a flow rate	978:988	a flow rate of approximately 400 nL min-1	978:1018	Within one run lasting 25 min, at a flow rate of approximately 400 nL min-1, eight couples of enantiomers were baseline-resolved and four of them were separated in less than 25 min.
34885676	1	57	theme	chromatographic	140:154	arg1	application					156:166	A novel chromatographic application	132:166	A novel chromatographic application in chiral separation by using the nano-LC technique	132:218	A novel chromatographic application in chiral separation by using the nano-LC technique is here reported.
34885676	3	58	theme	phase	477:481	arg1	composition					483:493	The mobile phase composition	466:493	The mobile phase composition	466:493	The mobile phase composition and the experimental conditions were optimized in order to find the optimum chiral separation for some selected racemic mixtures of imidazole and triazole derivatives.
34885676	2	59	theme	CSP-cellulose	366:378	arg1	CDCPC					409:413	CDCPC	409:413	CDCPC	409:413	The chiral recognition of 12 antifungal drugs was obtained through a 75 µm I.D. fused-silica capillary, which was packed with a CSP-cellulose 3,5-dichlorophenylcarbamate (CDCPC), by means of a lab-made slurry packing procedure.
34885676	2	59	theme	CSP-cellulose	366:378	arg1	3,5-dichlorophenylcarbamate					380:406	a CSP-cellulose 3,5-dichlorophenylcarbamate	364:406	a CSP-cellulose 3,5-dichlorophenylcarbamate (CDCPC)	364:414	The chiral recognition of 12 antifungal drugs was obtained through a 75 µm I.D. fused-silica capillary, which was packed with a CSP-cellulose 3,5-dichlorophenylcarbamate (CDCPC), by means of a lab-made slurry packing procedure.
34885676	5	60	dep	eight	1021:1025	arg1	couples					1027:1033	couples	1027:1033	couples of enantiomers were baseline-resolved	1027:1071	Within one run lasting 25 min, at a flow rate of approximately 400 nL min-1, eight couples of enantiomers were baseline-resolved and four of them were separated in less than 25 min.
34885676	2	61	theme	packing	447:453	arg1	procedure					455:463	a lab-made slurry packing procedure	429:463	a lab-made slurry packing procedure	429:463	The chiral recognition of 12 antifungal drugs was obtained through a 75 µm I.D. fused-silica capillary, which was packed with a CSP-cellulose 3,5-dichlorophenylcarbamate (CDCPC), by means of a lab-made slurry packing procedure.
33189756	0	0	theme	Cu	92:93	arg1	release					65:71	sustained release	55:71	sustained release of antibiotics and Cu used for bone tissue bacteria infection	55:133	Long-term antibacterial composite via alginate aerogel sustained release of antibiotics and Cu used for bone tissue bacteria infection.
33189756	6	1	theme	alginate	968:975	arg1	aerogel					977:983	the alginate aerogel	964:983	the alginate aerogel	964:983	These remarkable results suggested that the alginate aerogel exhibits great potential for the treatment of OM, and has a prosperous future of application in bone tissue engineering.
33189756	2	2	theme	antibacterial	480:492	arg1	applications					522:533	antibacterial and local infection therapy applications	480:533	antibacterial and local infection therapy applications	480:533	In this work, we report an exceptional effective antibacterial alginate aerogel, which consists of tigecycline (TGC) and octahedral Cu crystal as an organo-inorganic synergy platform for antibacterial and local infection therapy applications.
33189756	6	3	from	prosperous	1045:1054	arg1	engineering					1093:1103	bone tissue engineering	1081:1103	bone tissue engineering	1081:1103	These remarkable results suggested that the alginate aerogel exhibits great potential for the treatment of OM, and has a prosperous future of application in bone tissue engineering.
33189756	1	4	theme	wound	178:182	arg1	infections					184:193	wound infections	178:193	wound infections	178:193	Bone related-bacterial diseases including wound infections and osteomyelitis (OM) remain a serious problem accompanied with amputation in most severe cases.
33189756	4	5	theme	antibacterial	786:798	arg1	activity					800:807	antibacterial activity	786:807	antibacterial activity	786:807	The result of in-vitro experiments demonstrated that the alginate aerogel has an exceptional effective function on antibacterial activity.
33189756	1	6	theme	most	274:277	arg1	cases					286:290	most severe cases	274:290	most severe cases	274:290	Bone related-bacterial diseases including wound infections and osteomyelitis (OM) remain a serious problem accompanied with amputation in most severe cases.
33189756	1	7	theme	severe	279:284	arg1	cases					286:290	most severe cases	274:290	most severe cases	274:290	Bone related-bacterial diseases including wound infections and osteomyelitis (OM) remain a serious problem accompanied with amputation in most severe cases.
33189756	0	8	theme	tissue	109:114	arg1	bacteria					116:123	bone tissue bacteria	104:123	bone tissue bacteria infection	104:133	Long-term antibacterial composite via alginate aerogel sustained release of antibiotics and Cu used for bone tissue bacteria infection.
33189756	6	9	theme	tissue	1086:1091	arg1	engineering					1093:1103	bone tissue engineering	1081:1103	bone tissue engineering	1081:1103	These remarkable results suggested that the alginate aerogel exhibits great potential for the treatment of OM, and has a prosperous future of application in bone tissue engineering.
33189756	3	10	theme	alginate	540:547	arg1	aerogel					549:555	The alginate aerogel	536:555	The alginate aerogel	536:555	The alginate aerogel could greatly prolong the release of copper ions and maintain effective antibacterial concentration over 18 days.
33189756	4	11	theme	in-vitro	685:692	arg1	experiments					694:704	in-vitro experiments	685:704	in-vitro experiments	685:704	The result of in-vitro experiments demonstrated that the alginate aerogel has an exceptional effective function on antibacterial activity.
33189756	0	12	theme	bone	104:107	arg1	bacteria					116:123	bone tissue bacteria	104:123	bone tissue bacteria infection	104:133	Long-term antibacterial composite via alginate aerogel sustained release of antibiotics and Cu used for bone tissue bacteria infection.
33189756	4	13	contain	has	745:747	arg2	function					774:781	an exceptional effective function	749:781	an exceptional effective function	749:781	The result of in-vitro experiments demonstrated that the alginate aerogel has an exceptional effective function on antibacterial activity.
33189756	4	13	contain	has	745:747	arg1	aerogel					737:743	the alginate aerogel	724:743	the alginate aerogel	724:743	The result of in-vitro experiments demonstrated that the alginate aerogel has an exceptional effective function on antibacterial activity.
33189756	5	14	theme	low	869:871	arg1	%					920:920	average cell viability >75%	894:920	average cell viability >75%	894:920	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	5	14	theme	low	869:871	arg1	toxicity					884:891	low biological toxicity	869:891	low biological toxicity (average cell viability >75%)	869:921	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	0	15	theme	antibacterial	10:22	arg1	composite					24:32	Long-term antibacterial composite	0:32	Long-term antibacterial composite via alginate	0:45	Long-term antibacterial composite via alginate aerogel sustained release of antibiotics and Cu used for bone tissue bacteria infection.
33189756	0	16	theme	antibiotics	76:86	arg1	release					65:71	sustained release	55:71	sustained release of antibiotics and Cu used for bone tissue bacteria infection	55:133	Long-term antibacterial composite via alginate aerogel sustained release of antibiotics and Cu used for bone tissue bacteria infection.
33189756	0	17	theme	Long-term	0:8	arg1	composite					24:32	Long-term antibacterial composite	0:32	Long-term antibacterial composite via alginate	0:45	Long-term antibacterial composite via alginate aerogel sustained release of antibiotics and Cu used for bone tissue bacteria infection.
33189756	6	18	theme	OM	1031:1032	arg1	treatment					1018:1026	the treatment	1014:1026	the treatment of OM	1014:1032	These remarkable results suggested that the alginate aerogel exhibits great potential for the treatment of OM, and has a prosperous future of application in bone tissue engineering.
33189756	4	19	theme	exceptional	752:762	arg1	function					774:781	an exceptional effective function	749:781	an exceptional effective function	749:781	The result of in-vitro experiments demonstrated that the alginate aerogel has an exceptional effective function on antibacterial activity.
33189756	4	20	theme	alginate	728:735	arg1	aerogel					737:743	the alginate aerogel	724:743	the alginate aerogel	724:743	The result of in-vitro experiments demonstrated that the alginate aerogel has an exceptional effective function on antibacterial activity.
33189756	5	21	theme	biological	873:882	arg1	%					920:920	average cell viability >75%	894:920	average cell viability >75%	894:920	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	5	21	theme	biological	873:882	arg1	toxicity					884:891	low biological toxicity	869:891	low biological toxicity (average cell viability >75%)	869:921	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	5	22	theme	alginate	848:855	arg1	aerogel					857:863	the alginate aerogel	844:863	the alginate aerogel	844:863	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	2	23	theme	octahedral	414:423	arg1	crystal					428:434	octahedral Cu crystal	414:434	octahedral Cu crystal	414:434	In this work, we report an exceptional effective antibacterial alginate aerogel, which consists of tigecycline (TGC) and octahedral Cu crystal as an organo-inorganic synergy platform for antibacterial and local infection therapy applications.
33189756	2	24	theme	Cu	425:426	arg1	crystal					428:434	octahedral Cu crystal	414:434	octahedral Cu crystal	414:434	In this work, we report an exceptional effective antibacterial alginate aerogel, which consists of tigecycline (TGC) and octahedral Cu crystal as an organo-inorganic synergy platform for antibacterial and local infection therapy applications.
33189756	0	25	theme	bacteria	116:123	arg1	infection					125:133	bone tissue bacteria infection	104:133	bone tissue bacteria infection	104:133	Long-term antibacterial composite via alginate aerogel sustained release of antibiotics and Cu used for bone tissue bacteria infection.
33189756	2	26	theme	alginate	356:363	arg1	aerogel					365:371	an exceptional effective antibacterial alginate aerogel	317:371	an exceptional effective antibacterial alginate aerogel	317:371	In this work, we report an exceptional effective antibacterial alginate aerogel, which consists of tigecycline (TGC) and octahedral Cu crystal as an organo-inorganic synergy platform for antibacterial and local infection therapy applications.
33189756	5	27	theme	average	894:900	arg1	%					920:920	average cell viability >75%	894:920	average cell viability >75%	894:920	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	5	27	theme	average	894:900	arg1	toxicity					884:891	low biological toxicity	869:891	low biological toxicity (average cell viability >75%)	869:921	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	1	28	from	amputation	260:269	arg1	cases					286:290	most severe cases	274:290	most severe cases	274:290	Bone related-bacterial diseases including wound infections and osteomyelitis (OM) remain a serious problem accompanied with amputation in most severe cases.
33189756	6	29	theme	bone	1081:1084	arg1	engineering					1093:1103	bone tissue engineering	1081:1103	bone tissue engineering	1081:1103	These remarkable results suggested that the alginate aerogel exhibits great potential for the treatment of OM, and has a prosperous future of application in bone tissue engineering.
33189756	4	30	theme	experiments	694:704	arg1	result					675:680	The result	671:680	The result of in-vitro experiments	671:704	The result of in-vitro experiments demonstrated that the alginate aerogel has an exceptional effective function on antibacterial activity.
33189756	5	31	theme	cell	902:905	arg1	%					920:920	average cell viability >75%	894:920	average cell viability >75%	894:920	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	5	31	theme	cell	902:905	arg1	toxicity					884:891	low biological toxicity	869:891	low biological toxicity (average cell viability >75%)	869:921	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	2	32	theme	therapy	514:520	arg1	applications					522:533	antibacterial and local infection therapy applications	480:533	antibacterial and local infection therapy applications	480:533	In this work, we report an exceptional effective antibacterial alginate aerogel, which consists of tigecycline (TGC) and octahedral Cu crystal as an organo-inorganic synergy platform for antibacterial and local infection therapy applications.
33189756	2	33	theme	synergy	459:465	arg1	platform					467:474	an organo-inorganic synergy platform	439:474	an organo-inorganic synergy platform for antibacterial and local infection therapy applications	439:533	In this work, we report an exceptional effective antibacterial alginate aerogel, which consists of tigecycline (TGC) and octahedral Cu crystal as an organo-inorganic synergy platform for antibacterial and local infection therapy applications.
33189756	5	34	contain	has	865:867	arg2	toxicity					884:891	low biological toxicity	869:891	low biological toxicity (average cell viability >75%)	869:921	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	5	34	contain	has	865:867	arg2	%					920:920	average cell viability >75%	894:920	average cell viability >75%	894:920	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	5	34	contain	has	865:867	arg1	aerogel					857:863	the alginate aerogel	844:863	the alginate aerogel	844:863	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	3	35	theme	copper	594:599	arg1	ions					601:604	copper ions	594:604	copper ions	594:604	The alginate aerogel could greatly prolong the release of copper ions and maintain effective antibacterial concentration over 18 days.
33189756	6	36	theme	remarkable	930:939	arg1	results					941:947	These remarkable results	924:947	These remarkable results	924:947	These remarkable results suggested that the alginate aerogel exhibits great potential for the treatment of OM, and has a prosperous future of application in bone tissue engineering.
33189756	2	37	theme	antibacterial	342:354	arg1	aerogel					365:371	an exceptional effective antibacterial alginate aerogel	317:371	an exceptional effective antibacterial alginate aerogel	317:371	In this work, we report an exceptional effective antibacterial alginate aerogel, which consists of tigecycline (TGC) and octahedral Cu crystal as an organo-inorganic synergy platform for antibacterial and local infection therapy applications.
33189756	0	38	theme	sustained	55:63	arg1	release					65:71	sustained release	55:71	sustained release of antibiotics and Cu used for bone tissue bacteria infection	55:133	Long-term antibacterial composite via alginate aerogel sustained release of antibiotics and Cu used for bone tissue bacteria infection.
33189756	6	39	theme	great	994:998	arg1	potential					1000:1008	great potential	994:1008	great potential for the treatment of OM	994:1032	These remarkable results suggested that the alginate aerogel exhibits great potential for the treatment of OM, and has a prosperous future of application in bone tissue engineering.
33189756	2	40	theme	organo-inorganic	442:457	arg1	platform					467:474	an organo-inorganic synergy platform	439:474	an organo-inorganic synergy platform for antibacterial and local infection therapy applications	439:533	In this work, we report an exceptional effective antibacterial alginate aerogel, which consists of tigecycline (TGC) and octahedral Cu crystal as an organo-inorganic synergy platform for antibacterial and local infection therapy applications.
33189756	3	41	theme	ions	601:604	arg1	release					583:589	the release	579:589	the release of copper ions	579:604	The alginate aerogel could greatly prolong the release of copper ions and maintain effective antibacterial concentration over 18 days.
33189756	2	42	theme	effective	332:340	arg1	aerogel					365:371	an exceptional effective antibacterial alginate aerogel	317:371	an exceptional effective antibacterial alginate aerogel	317:371	In this work, we report an exceptional effective antibacterial alginate aerogel, which consists of tigecycline (TGC) and octahedral Cu crystal as an organo-inorganic synergy platform for antibacterial and local infection therapy applications.
33189756	5	43	theme	Cytotoxicity	810:821	arg1	tests					823:827	Cytotoxicity tests	810:827	Cytotoxicity tests	810:827	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	2	44	theme	exceptional	320:330	arg1	aerogel					365:371	an exceptional effective antibacterial alginate aerogel	317:371	an exceptional effective antibacterial alginate aerogel	317:371	In this work, we report an exceptional effective antibacterial alginate aerogel, which consists of tigecycline (TGC) and octahedral Cu crystal as an organo-inorganic synergy platform for antibacterial and local infection therapy applications.
33189756	6	45	contain	has	1039:1041	arg2	prosperous					1045:1054	a prosperous future	1043:1061	a prosperous future of application in bone tissue engineering	1043:1103	These remarkable results suggested that the alginate aerogel exhibits great potential for the treatment of OM, and has a prosperous future of application in bone tissue engineering.
33189756	6	45	contain	has	1039:1041	arg1	aerogel					977:983	the alginate aerogel	964:983	the alginate aerogel	964:983	These remarkable results suggested that the alginate aerogel exhibits great potential for the treatment of OM, and has a prosperous future of application in bone tissue engineering.
33189756	1	46	theme	serious	227:233	arg1	problem					235:241	a serious problem	225:241	a serious problem accompanied with amputation in most severe cases	225:290	Bone related-bacterial diseases including wound infections and osteomyelitis (OM) remain a serious problem accompanied with amputation in most severe cases.
33189756	1	47	theme	Bone	136:139	arg1	osteomyelitis					199:211	osteomyelitis	199:211	osteomyelitis (OM)	199:216	Bone related-bacterial diseases including wound infections and osteomyelitis (OM) remain a serious problem accompanied with amputation in most severe cases.
33189756	1	47	theme	Bone	136:139	arg1	diseases					159:166	Bone related-bacterial diseases	136:166	Bone related-bacterial diseases including wound infections and osteomyelitis (OM)	136:216	Bone related-bacterial diseases including wound infections and osteomyelitis (OM) remain a serious problem accompanied with amputation in most severe cases.
33189756	1	47	theme	Bone	136:139	arg1	infections					184:193	wound infections	178:193	wound infections	178:193	Bone related-bacterial diseases including wound infections and osteomyelitis (OM) remain a serious problem accompanied with amputation in most severe cases.
33189756	4	48	theme	effective	764:772	arg1	function					774:781	an exceptional effective function	749:781	an exceptional effective function	749:781	The result of in-vitro experiments demonstrated that the alginate aerogel has an exceptional effective function on antibacterial activity.
33189756	2	49	theme	infection	504:512	arg1	applications					522:533	antibacterial and local infection therapy applications	480:533	antibacterial and local infection therapy applications	480:533	In this work, we report an exceptional effective antibacterial alginate aerogel, which consists of tigecycline (TGC) and octahedral Cu crystal as an organo-inorganic synergy platform for antibacterial and local infection therapy applications.
33189756	5	50	theme	viability	907:915	arg1	%					920:920	average cell viability >75%	894:920	average cell viability >75%	894:920	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	5	50	theme	viability	907:915	arg1	toxicity					884:891	low biological toxicity	869:891	low biological toxicity (average cell viability >75%)	869:921	Cytotoxicity tests indicated that the alginate aerogel has low biological toxicity (average cell viability >75%).
33189756	3	51	theme	effective	619:627	arg1	concentration					643:655	effective antibacterial concentration	619:655	effective antibacterial concentration over 18 days	619:668	The alginate aerogel could greatly prolong the release of copper ions and maintain effective antibacterial concentration over 18 days.
33189756	1	52	theme	related-bacterial	141:157	arg1	osteomyelitis					199:211	osteomyelitis	199:211	osteomyelitis (OM)	199:216	Bone related-bacterial diseases including wound infections and osteomyelitis (OM) remain a serious problem accompanied with amputation in most severe cases.
33189756	1	52	theme	related-bacterial	141:157	arg1	diseases					159:166	Bone related-bacterial diseases	136:166	Bone related-bacterial diseases including wound infections and osteomyelitis (OM)	136:216	Bone related-bacterial diseases including wound infections and osteomyelitis (OM) remain a serious problem accompanied with amputation in most severe cases.
33189756	1	52	theme	related-bacterial	141:157	arg1	infections					184:193	wound infections	178:193	wound infections	178:193	Bone related-bacterial diseases including wound infections and osteomyelitis (OM) remain a serious problem accompanied with amputation in most severe cases.
33189756	6	53	theme	future	1056:1061	arg1	prosperous					1045:1054	a prosperous future	1043:1061	a prosperous future of application in bone tissue engineering	1043:1103	These remarkable results suggested that the alginate aerogel exhibits great potential for the treatment of OM, and has a prosperous future of application in bone tissue engineering.
33189756	2	54	theme	local	498:502	arg1	applications					522:533	antibacterial and local infection therapy applications	480:533	antibacterial and local infection therapy applications	480:533	In this work, we report an exceptional effective antibacterial alginate aerogel, which consists of tigecycline (TGC) and octahedral Cu crystal as an organo-inorganic synergy platform for antibacterial and local infection therapy applications.
33189756	3	55	theme	antibacterial	629:641	arg1	concentration					643:655	effective antibacterial concentration	619:655	effective antibacterial concentration over 18 days	619:668	The alginate aerogel could greatly prolong the release of copper ions and maintain effective antibacterial concentration over 18 days.
33189756	6	56	theme	application	1066:1076	arg1	prosperous					1045:1054	a prosperous future	1043:1061	a prosperous future of application in bone tissue engineering	1043:1103	These remarkable results suggested that the alginate aerogel exhibits great potential for the treatment of OM, and has a prosperous future of application in bone tissue engineering.
34495638	2	0	theme	magnetic	353:360	arg1	MNPs					377:380	MNPs	377:380	MNPs	377:380	A composite-actuating string was fabricated with magnetic nanoparticles (MNPs) and Gluconacetobacter xylinus in a solid matrix of hydrophobic microparticles.
34495638	2	0	theme	magnetic	353:360	arg1	nanoparticles					362:374	magnetic nanoparticles	353:374	magnetic nanoparticles (MNPs)	353:381	A composite-actuating string was fabricated with magnetic nanoparticles (MNPs) and Gluconacetobacter xylinus in a solid matrix of hydrophobic microparticles.
34495638	4	1	theme	organ	847:851	arg1	tissues					853:859	organ tissues	847:859	organ tissues	847:859	The nanofibrous actuator string is transformable to fit the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues.
34495638	3	2	theme	cellulose	507:515	arg1	nanofibers					517:526	cellulose nanofibers	507:526	cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field	507:629	G. xylinus synthesizes a dense skin layer of cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field.
34495638	4	3	theme	due	746:748	arg1	section					738:744	cross section	732:744	cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues	732:859	The nanofibrous actuator string is transformable to fit the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues.
34495638	1	4	theme	oxygen	249:254	arg1	diffusion					167:175	the diffusion	163:175	the diffusion of colloidal particles and bacteria to the bulk	163:223	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	1	4	theme	oxygen	249:254	arg1	supply					239:244	a limited supply	229:244	a limited supply of oxygen for bacteria in the liquid culture environment	229:301	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	4	5	theme	tissues	853:859	arg1	walls					838:842	the walls	834:842	the walls of organ tissues	834:859	The nanofibrous actuator string is transformable to fit the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues.
34495638	3	6	theme	solid	550:554	arg1	matrix					556:561	the solid matrix	546:561	the solid matrix	546:561	G. xylinus synthesizes a dense skin layer of cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field.
34495638	3	7	theme	dense	487:491	arg1	layer					498:502	a dense skin layer	485:502	a dense skin layer of cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field	485:629	G. xylinus synthesizes a dense skin layer of cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field.
34495638	4	8	theme	tubular	710:716	arg1	structures					718:727	tubular structures	710:727	tubular structures	710:727	The nanofibrous actuator string is transformable to fit the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues.
34495638	4	9	theme	plastic	770:776	arg1	deformability					778:790	plastic deformability	770:790	plastic deformability	770:790	The nanofibrous actuator string is transformable to fit the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues.
34495638	2	10	theme	Gluconacetobacter	387:403	arg1	xylinus					405:411	Gluconacetobacter xylinus	387:411	Gluconacetobacter xylinus	387:411	A composite-actuating string was fabricated with magnetic nanoparticles (MNPs) and Gluconacetobacter xylinus in a solid matrix of hydrophobic microparticles.
34495638	1	11	with	formation	73:81	arg1	suspension					130:139	a colloidal suspension	118:139	a colloidal suspension	118:139	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	2	12	theme	hydrophobic	434:444	arg1	microparticles					446:459	hydrophobic microparticles	434:459	hydrophobic microparticles	434:459	A composite-actuating string was fabricated with magnetic nanoparticles (MNPs) and Gluconacetobacter xylinus in a solid matrix of hydrophobic microparticles.
34495638	0	13	theme	Magnetostrictive	5:20	arg1	String					31:36	Soft Magnetostrictive Actuator String	0:36	Soft Magnetostrictive Actuator String with Cellulose Nanofiber Skin.	0:67	Soft Magnetostrictive Actuator String with Cellulose Nanofiber Skin.
34495638	1	14	from	bacteria	260:267	arg1	environment					291:301	the liquid culture environment	272:301	the liquid culture environment	272:301	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	5	15	from	angle	914:918	arg1	applicable					949:958	applicable	949:958	applicable	949:958	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	5	15	from	angle	914:918	arg1	bendable					893:900	bendable	893:900	bendable	893:900	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	5	15	from	angle	914:918	arg1	string					883:888	The nanofibrous skin string	862:888	The nanofibrous skin string	862:888	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	1	16	theme	cellulose	86:94	arg1	skin					108:111	cellulose nanofibrous skin	86:111	cellulose nanofibrous skin	86:111	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	1	17	theme	colloidal	180:188	arg1	particles					190:198	colloidal particles	180:198	colloidal particles	180:198	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	0	18	theme	Soft	0:3	arg1	String					31:36	Soft Magnetostrictive Actuator String	0:36	Soft Magnetostrictive Actuator String with Cellulose Nanofiber Skin.	0:67	Soft Magnetostrictive Actuator String with Cellulose Nanofiber Skin.
34495638	4	19	theme	structures	718:727	arg1	shapes					700:705	the diverse shapes	688:705	the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues	688:859	The nanofibrous actuator string is transformable to fit the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues.
34495638	1	20	theme	nanofibrous	96:106	arg1	skin					108:111	cellulose nanofibrous skin	86:111	cellulose nanofibrous skin	86:111	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	1	21	theme	particles	190:198	arg1	diffusion					167:175	the diffusion	163:175	the diffusion of colloidal particles and bacteria to the bulk	163:223	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	1	21	theme	particles	190:198	arg1	supply					239:244	a limited supply	229:244	a limited supply of oxygen for bacteria in the liquid culture environment	229:301	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	4	22	theme	cross	732:736	arg1	section					738:744	cross section	732:744	cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues	732:859	The nanofibrous actuator string is transformable to fit the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues.
34495638	1	23	theme	skin	108:111	arg1	formation					73:81	The formation	69:81	The formation of cellulose nanofibrous skin with a colloidal suspension	69:139	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	2	24	theme	solid	418:422	arg1	matrix					424:429	a solid matrix	416:429	a solid matrix of hydrophobic microparticles	416:459	A composite-actuating string was fabricated with magnetic nanoparticles (MNPs) and Gluconacetobacter xylinus in a solid matrix of hydrophobic microparticles.
34495638	0	25	theme	Actuator	22:29	arg1	String					31:36	Soft Magnetostrictive Actuator String	0:36	Soft Magnetostrictive Actuator String with Cellulose Nanofiber Skin.	0:67	Soft Magnetostrictive Actuator String with Cellulose Nanofiber Skin.
34495638	5	26	theme	magnetic	923:930	arg1	actuation					932:940	magnetic actuation	923:940	magnetic actuation	923:940	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	4	27	theme	diverse	692:698	arg1	shapes					700:705	the diverse shapes	688:705	the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues	688:859	The nanofibrous actuator string is transformable to fit the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues.
34495638	1	28	theme	bacteria	204:211	arg1	diffusion					167:175	the diffusion	163:175	the diffusion of colloidal particles and bacteria to the bulk	163:223	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	1	28	theme	bacteria	204:211	arg1	supply					239:244	a limited supply	229:244	a limited supply of oxygen for bacteria in the liquid culture environment	229:301	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	0	29	theme	Cellulose	43:51	arg1	Skin					63:66	Cellulose Nanofiber Skin	43:66	Cellulose Nanofiber Skin	43:66	Soft Magnetostrictive Actuator String with Cellulose Nanofiber Skin.
34495638	1	30	theme	liquid	276:281	arg1	environment					291:301	the liquid culture environment	272:301	the liquid culture environment	272:301	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	3	31	theme	responsive	590:599	arg1	string					583:588	an actuator string	571:588	an actuator string responsive to an external magnetic field	571:629	G. xylinus synthesizes a dense skin layer of cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field.
34495638	5	32	theme	nanofibrous	866:876	arg1	applicable					949:958	applicable	949:958	applicable	949:958	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	5	32	theme	nanofibrous	866:876	arg1	bendable					893:900	bendable	893:900	bendable	893:900	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	5	32	theme	nanofibrous	866:876	arg1	string					883:888	The nanofibrous skin string	862:888	The nanofibrous skin string	862:888	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	4	33	theme	actuator	648:655	arg1	transformable					667:679	transformable	667:679	transformable	667:679	The nanofibrous actuator string is transformable to fit the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues.
34495638	4	33	theme	actuator	648:655	arg1	string					657:662	The nanofibrous actuator string	632:662	The nanofibrous actuator string	632:662	The nanofibrous actuator string is transformable to fit the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues.
34495638	1	34	theme	culture	283:289	arg1	environment					291:301	the liquid culture environment	272:301	the liquid culture environment	272:301	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	0	35	with	String	31:36	arg1	Skin					63:66	Cellulose Nanofiber Skin	43:66	Cellulose Nanofiber Skin	43:66	Soft Magnetostrictive Actuator String with Cellulose Nanofiber Skin.
34495638	4	36	theme	nanofibrous	636:646	arg1	transformable					667:679	transformable	667:679	transformable	667:679	The nanofibrous actuator string is transformable to fit the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues.
34495638	4	36	theme	nanofibrous	636:646	arg1	string					657:662	The nanofibrous actuator string	632:662	The nanofibrous actuator string	632:662	The nanofibrous actuator string is transformable to fit the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues.
34495638	5	37	theme	skin	878:881	arg1	applicable					949:958	applicable	949:958	applicable	949:958	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	5	37	theme	skin	878:881	arg1	bendable					893:900	bendable	893:900	bendable	893:900	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	5	37	theme	skin	878:881	arg1	string					883:888	The nanofibrous skin string	862:888	The nanofibrous skin string	862:888	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	3	38	theme	actuator	574:581	arg1	string					583:588	an actuator string	571:588	an actuator string responsive to an external magnetic field	571:629	G. xylinus synthesizes a dense skin layer of cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field.
34495638	3	39	theme	skin	493:496	arg1	layer					498:502	a dense skin layer	485:502	a dense skin layer of cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field	485:629	G. xylinus synthesizes a dense skin layer of cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field.
34495638	0	40	theme	Nanofiber	53:61	arg1	Skin					63:66	Cellulose Nanofiber Skin	43:66	Cellulose Nanofiber Skin	43:66	Soft Magnetostrictive Actuator String with Cellulose Nanofiber Skin.
34495638	5	41	theme	model	1019:1023	arg1	structure					1032:1040	a model kidney structure	1017:1040	a model kidney structure	1017:1040	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	1	42	theme	colloidal	120:128	arg1	suspension					130:139	a colloidal suspension	118:139	a colloidal suspension	118:139	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34495638	5	43	theme	endoscopic	966:975	arg1	guidewire					977:985	an endoscopic guidewire	963:985	an endoscopic guidewire to reach a target deep inside a model kidney structure	963:1040	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	3	44	theme	magnetic	616:623	arg1	field					625:629	an external magnetic field	604:629	an external magnetic field	604:629	G. xylinus synthesizes a dense skin layer of cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field.
34495638	5	45	theme	acute	908:912	arg1	angle					914:918	an acute angle	905:918	an acute angle by magnetic actuation	905:940	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	5	46	theme	kidney	1025:1030	arg1	structure					1032:1040	a model kidney structure	1017:1040	a model kidney structure	1017:1040	The nanofibrous skin string is bendable at an acute angle by magnetic actuation and is applicable as an endoscopic guidewire to reach a target deep inside a model kidney structure.
34495638	2	47	theme	composite-actuating	306:324	arg1	string					326:331	A composite-actuating string	304:331	A composite-actuating string	304:331	A composite-actuating string was fabricated with magnetic nanoparticles (MNPs) and Gluconacetobacter xylinus in a solid matrix of hydrophobic microparticles.
34495638	4	48	from	shapes	700:705	arg1	section					738:744	cross section	732:744	cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues	732:859	The nanofibrous actuator string is transformable to fit the diverse shapes of tubular structures in cross section due to its softness and plastic deformability, which reduce friction and stress against the walls of organ tissues.
34495638	3	49	theme	nanofibers	517:526	arg1	layer					498:502	a dense skin layer	485:502	a dense skin layer of cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field	485:629	G. xylinus synthesizes a dense skin layer of cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field.
34495638	3	50	theme	external	607:614	arg1	field					625:629	an external magnetic field	604:629	an external magnetic field	604:629	G. xylinus synthesizes a dense skin layer of cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field.
34495638	2	51	theme	microparticles	446:459	arg1	matrix					424:429	a solid matrix	416:429	a solid matrix of hydrophobic microparticles	416:459	A composite-actuating string was fabricated with magnetic nanoparticles (MNPs) and Gluconacetobacter xylinus in a solid matrix of hydrophobic microparticles.
34495638	3	52	from	MNPs	538:541	arg1	matrix					556:561	the solid matrix	546:561	the solid matrix	546:561	G. xylinus synthesizes a dense skin layer of cellulose nanofibers enclosing MNPs in the solid matrix to form an actuator string responsive to an external magnetic field.
34495638	1	53	theme	limited	231:237	arg1	supply					239:244	a limited supply	229:244	a limited supply of oxygen for bacteria in the liquid culture environment	229:301	The formation of cellulose nanofibrous skin with a colloidal suspension is challenging due to the diffusion of colloidal particles and bacteria to the bulk and a limited supply of oxygen for bacteria in the liquid culture environment.
34846904	6	0	theme	glucan	1042:1047	arg1	chain					1049:1053	the glucan chain	1038:1053	the glucan chain	1038:1053	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34846904	1	1	from	functions	222:230	arg1	organisms					235:243	organisms	235:243	organisms	235:243	Biomineralization generates hierarchically structured minerals with vital biological functions in organisms.
34846904	0	2	theme	Bacterial	85:93	arg1	Cellulose					95:103	Bacterial Cellulose	85:103	Bacterial Cellulose for More Robust Nanocomposites	85:134	Molecular Origin of the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites.
34846904	0	3	from	Origin	10:15	arg1	Cellulose					95:103	Bacterial Cellulose	85:103	Bacterial Cellulose for More Robust Nanocomposites	85:134	Molecular Origin of the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites.
34846904	5	4	theme	cellulose	698:706	arg1	molecules					708:716	the newly biosynthesized cellulose molecules	673:716	the newly biosynthesized cellulose molecules	673:716	In comparison with mature cellulose, the newly biosynthesized cellulose molecules greatly accelerate the nucleation rate and facilitate the uniform distribution of HAp crystals, thereby generating composites with a higher Young modulus.
34846904	1	5	theme	vital	205:209	arg1	functions					222:230	vital biological functions	205:230	vital biological functions in organisms	205:243	Biomineralization generates hierarchically structured minerals with vital biological functions in organisms.
34846904	4	6	theme	hydroxyapatite	536:549	arg1	mineralization					518:531	the mineralization	514:531	the mineralization of hydroxyapatite (HAp) accompanying the biological secretion of nanocellulose by Acetobacter xylinum	514:633	Herein, we describe the mineralization of hydroxyapatite (HAp) accompanying the biological secretion of nanocellulose by Acetobacter xylinum.
34846904	4	7	theme	nanocellulose	598:610	arg1	secretion					585:593	the biological secretion	570:593	the biological secretion of nanocellulose by Acetobacter xylinum	570:633	Herein, we describe the mineralization of hydroxyapatite (HAp) accompanying the biological secretion of nanocellulose by Acetobacter xylinum.
34846904	5	8	theme	uniform	776:782	arg1	distribution					784:795	the uniform distribution	772:795	the uniform distribution of HAp crystals	772:811	In comparison with mature cellulose, the newly biosynthesized cellulose molecules greatly accelerate the nucleation rate and facilitate the uniform distribution of HAp crystals, thereby generating composites with a higher Young modulus.
34846904	5	9	with	comparison	639:648	arg1	cellulose					662:670	mature cellulose	655:670	mature cellulose	655:670	In comparison with mature cellulose, the newly biosynthesized cellulose molecules greatly accelerate the nucleation rate and facilitate the uniform distribution of HAp crystals, thereby generating composites with a higher Young modulus.
34846904	5	10	theme	higher	851:856	arg1	modulus					864:870	a higher Young modulus	849:870	a higher Young modulus	849:870	In comparison with mature cellulose, the newly biosynthesized cellulose molecules greatly accelerate the nucleation rate and facilitate the uniform distribution of HAp crystals, thereby generating composites with a higher Young modulus.
34846904	1	11	with	minerals	191:198	arg1	functions					222:230	vital biological functions	205:230	vital biological functions in organisms	205:243	Biomineralization generates hierarchically structured minerals with vital biological functions in organisms.
34846904	6	12	theme	metabolism	935:944	arg1	condition					946:954	the biological metabolism condition	920:954	the biological metabolism condition	920:954	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34846904	3	13	theme	molecular	420:428	arg1	origin					430:435	The molecular origin	416:435	The molecular origin of the biofacilitated mineralization process	416:480	The molecular origin of the biofacilitated mineralization process is elusive.
34846904	3	13	theme	molecular	420:428	arg1	elusive					485:491	elusive	485:491	elusive	485:491	The molecular origin of the biofacilitated mineralization process is elusive.
34846904	0	14	from	Mineralization	49:62	arg1	Cellulose					95:103	Bacterial Cellulose	85:103	Bacterial Cellulose for More Robust Nanocomposites	85:134	Molecular Origin of the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites.
34846904	6	15	theme	biological	924:933	arg1	condition					946:954	the biological metabolism condition	920:954	the biological metabolism condition	920:954	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34846904	1	16	theme	biological	211:220	arg1	functions					222:230	vital biological functions	205:230	vital biological functions in organisms	205:243	Biomineralization generates hierarchically structured minerals with vital biological functions in organisms.
34846904	0	17	theme	Robust	114:119	arg1	Nanocomposites					121:134	More Robust Nanocomposites	109:134	More Robust Nanocomposites	109:134	Molecular Origin of the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites.
34846904	4	18	theme	biological	574:583	arg1	secretion					585:593	the biological secretion	570:593	the biological secretion of nanocellulose by Acetobacter xylinum	570:633	Herein, we describe the mineralization of hydroxyapatite (HAp) accompanying the biological secretion of nanocellulose by Acetobacter xylinum.
34846904	5	19	theme	nucleation	741:750	arg1	rate					752:755	the nucleation rate	737:755	the nucleation rate	737:755	In comparison with mature cellulose, the newly biosynthesized cellulose molecules greatly accelerate the nucleation rate and facilitate the uniform distribution of HAp crystals, thereby generating composites with a higher Young modulus.
34846904	2	20	theme	similar	323:329	arg1	functionalities					331:345	similar functionalities	323:345	similar functionalities	323:345	This strategy has been adopted to construct complex architectures to achieve similar functionalities, mostly under chemical environments mimicking biological components.
34846904	5	21	theme	Young	858:862	arg1	modulus					864:870	a higher Young modulus	849:870	a higher Young modulus	849:870	In comparison with mature cellulose, the newly biosynthesized cellulose molecules greatly accelerate the nucleation rate and facilitate the uniform distribution of HAp crystals, thereby generating composites with a higher Young modulus.
34846904	3	22	theme	process	474:480	arg1	origin					430:435	The molecular origin	416:435	The molecular origin of the biofacilitated mineralization process	416:480	The molecular origin of the biofacilitated mineralization process is elusive.
34846904	3	22	theme	process	474:480	arg1	elusive					485:491	elusive	485:491	elusive	485:491	The molecular origin of the biofacilitated mineralization process is elusive.
34846904	7	23	theme	mineralization	1206:1219	arg1	process					1221:1227	the biologically accelerated mineralization process	1177:1227	the biologically accelerated mineralization process	1177:1227	Our work provides more insights into the biologically accelerated mineralization process and presents a different methodology for the generation of biomimetic nanocomposites.
34846904	6	24	theme	hydroxyl	1019:1026	arg1	groups					1028:1033	the more abundant hydroxyl groups	1001:1033	the more abundant hydroxyl groups on the glucan chain	1001:1053	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34846904	0	25	theme	Molecular	0:8	arg1	Origin					10:15	Molecular Origin	0:15	Molecular Origin of the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites.	0:135	Molecular Origin of the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites.
34846904	3	26	theme	biofacilitated	444:457	arg1	process					474:480	the biofacilitated mineralization process	440:480	the biofacilitated mineralization process	440:480	The molecular origin of the biofacilitated mineralization process is elusive.
34846904	7	27	theme	different	1244:1252	arg1	methodology					1254:1264	a different methodology	1242:1264	a different methodology for the generation of biomimetic nanocomposites	1242:1312	Our work provides more insights into the biologically accelerated mineralization process and presents a different methodology for the generation of biomimetic nanocomposites.
34846904	5	28	theme	biosynthesized	683:696	arg1	molecules					708:716	the newly biosynthesized cellulose molecules	673:716	the newly biosynthesized cellulose molecules	673:716	In comparison with mature cellulose, the newly biosynthesized cellulose molecules greatly accelerate the nucleation rate and facilitate the uniform distribution of HAp crystals, thereby generating composites with a higher Young modulus.
34846904	2	29	theme	chemical	361:368	arg1	environments					370:381	chemical environments	361:381	chemical environments mimicking biological components	361:413	This strategy has been adopted to construct complex architectures to achieve similar functionalities, mostly under chemical environments mimicking biological components.
34846904	3	30	theme	mineralization	459:472	arg1	process					474:480	the biofacilitated mineralization process	440:480	the biofacilitated mineralization process	440:480	The molecular origin of the biofacilitated mineralization process is elusive.
34846904	6	31	theme	bonding	1088:1094	arg1	formation					1066:1074	the formation	1062:1074	the formation of hydrogen bonding	1062:1094	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34846904	7	32	theme	accelerated	1194:1204	arg1	process					1221:1227	the biologically accelerated mineralization process	1177:1227	the biologically accelerated mineralization process	1177:1227	Our work provides more insights into the biologically accelerated mineralization process and presents a different methodology for the generation of biomimetic nanocomposites.
34846904	0	33	from	Cellulose	95:103	arg1	Origin					10:15	Molecular Origin	0:15	Molecular Origin of the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites.	0:135	Molecular Origin of the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites.
34846904	0	34	theme	Accelerated	37:47	arg1	Mineralization					49:62	the Biologically Accelerated Mineralization	20:62	the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites	20:134	Molecular Origin of the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites.
34846904	6	35	theme	hydrogen	1079:1086	arg1	bonding					1088:1094	hydrogen bonding	1079:1094	hydrogen bonding	1079:1094	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34846904	7	36	theme	biomimetic	1288:1297	arg1	nanocomposites					1299:1312	biomimetic nanocomposites	1288:1312	biomimetic nanocomposites	1288:1312	Our work provides more insights into the biologically accelerated mineralization process and presents a different methodology for the generation of biomimetic nanocomposites.
34846904	6	37	theme	ions	993:996	arg1	capture					974:980	the easier capture	963:980	the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain	963:1053	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34846904	7	38	theme	nanocomposites	1299:1312	arg1	generation					1274:1283	the generation	1270:1283	the generation of biomimetic nanocomposites	1270:1312	Our work provides more insights into the biologically accelerated mineralization process and presents a different methodology for the generation of biomimetic nanocomposites.
34846904	4	39	theme	Acetobacter	615:625	arg1	xylinum					627:633	Acetobacter xylinum	615:633	Acetobacter xylinum	615:633	Herein, we describe the mineralization of hydroxyapatite (HAp) accompanying the biological secretion of nanocellulose by Acetobacter xylinum.
34846904	7	40	theme	more	1158:1161	arg1	insights					1163:1170	more insights	1158:1170	more insights into the biologically accelerated mineralization process	1158:1227	Our work provides more insights into the biologically accelerated mineralization process and presents a different methodology for the generation of biomimetic nanocomposites.
34846904	6	41	theme	calcium	985:991	arg1	ions					993:996	calcium ions	985:996	calcium ions	985:996	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34846904	6	42	theme	abundant	1010:1017	arg1	groups					1028:1033	the more abundant hydroxyl groups	1001:1033	the more abundant hydroxyl groups on the glucan chain	1001:1053	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34846904	0	43	theme	Mineralization	49:62	arg1	Origin					10:15	Molecular Origin	0:15	Molecular Origin of the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites.	0:135	Molecular Origin of the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites.
34846904	5	44	theme	HAp	800:802	arg1	crystals					804:811	HAp crystals	800:811	HAp crystals	800:811	In comparison with mature cellulose, the newly biosynthesized cellulose molecules greatly accelerate the nucleation rate and facilitate the uniform distribution of HAp crystals, thereby generating composites with a higher Young modulus.
34846904	5	45	theme	mature	655:660	arg1	cellulose					662:670	mature cellulose	655:670	mature cellulose	655:670	In comparison with mature cellulose, the newly biosynthesized cellulose molecules greatly accelerate the nucleation rate and facilitate the uniform distribution of HAp crystals, thereby generating composites with a higher Young modulus.
34846904	5	46	theme	crystals	804:811	arg1	distribution					784:795	the uniform distribution	772:795	the uniform distribution of HAp crystals	772:811	In comparison with mature cellulose, the newly biosynthesized cellulose molecules greatly accelerate the nucleation rate and facilitate the uniform distribution of HAp crystals, thereby generating composites with a higher Young modulus.
34846904	6	47	from	groups	1028:1033	arg1	chain					1049:1053	the glucan chain	1038:1053	the glucan chain	1038:1053	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34846904	6	48	theme	subsequent	1105:1114	arg1	growth					1116:1121	the subsequent growth	1101:1121	the subsequent growth of HAp crystals	1101:1137	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34846904	6	49	theme	easier	967:972	arg1	capture					974:980	the easier capture	963:980	the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain	963:1053	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34846904	2	50	theme	biological	393:402	arg1	components					404:413	biological components	393:413	biological components	393:413	This strategy has been adopted to construct complex architectures to achieve similar functionalities, mostly under chemical environments mimicking biological components.
34846904	1	51	theme	structured	180:189	arg1	minerals					191:198	hierarchically structured minerals	165:198	hierarchically structured minerals with vital biological functions in organisms	165:243	Biomineralization generates hierarchically structured minerals with vital biological functions in organisms.
34846904	6	52	theme	crystals	1130:1137	arg1	growth					1116:1121	the subsequent growth	1101:1121	the subsequent growth of HAp crystals	1101:1137	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34846904	0	53	theme	Hydroxyapatite	67:80	arg1	Mineralization					49:62	the Biologically Accelerated Mineralization	20:62	the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites	20:134	Molecular Origin of the Biologically Accelerated Mineralization of Hydroxyapatite on Bacterial Cellulose for More Robust Nanocomposites.
34846904	2	54	theme	complex	290:296	arg1	architectures					298:310	complex architectures	290:310	complex architectures	290:310	This strategy has been adopted to construct complex architectures to achieve similar functionalities, mostly under chemical environments mimicking biological components.
34846904	6	55	theme	HAp	1126:1128	arg1	crystals					1130:1137	HAp crystals	1126:1137	HAp crystals	1126:1137	Both simulations and experiments indicate that the biological metabolism condition allows the easier capture of calcium ions by the more abundant hydroxyl groups on the glucan chain before the formation of hydrogen bonding, for the subsequent growth of HAp crystals.
34309163	4	0	dep	0,0	724:726	arg1	0,1					734:736	0,1	734:736	four logic combinations: 0,0; 1,0; 0,1; 1,1	699:741	The enzymes were activated with biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1, having the production of H2 O2 as the result of the biocatalytic reactions.
34309163	4	0	dep	0,0	724:726	arg1	1,0					729:731	1,0	729:731	1,0	729:731	The enzymes were activated with biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1, having the production of H2 O2 as the result of the biocatalytic reactions.
34309163	4	0	dep	0,0	724:726	arg1	1,1					739:741	1,1	739:741	1,1	739:741	The enzymes were activated with biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1, having the production of H2 O2 as the result of the biocatalytic reactions.
34309163	4	1	theme	logic	704:708	arg1	combinations					710:721	four logic combinations	699:721	four logic combinations: 0,0; 1,0; 0,1; 1,1	699:741	The enzymes were activated with biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1, having the production of H2 O2 as the result of the biocatalytic reactions.
34309163	8	2	theme	medical	1351:1357	arg1	diagnostics					1359:1369	future medical diagnostics	1344:1369	future medical diagnostics	1344:1369	The smart soft material that we have developed tackled well-known limitations of these systems and it may prove valuable in future medical diagnostics or treatments.
34309163	3	3	theme	various	536:542	arg1	enzymes					544:550	various enzymes	536:550	various enzymes mimicking different Boolean logic gates (AND, OR, NOR, IMP, INHIB)	536:617	The beads were loaded with insulin and various enzymes mimicking different Boolean logic gates (AND, OR, NOR, IMP, INHIB).
34309163	8	4	theme	soft	1230:1233	arg1	material					1235:1242	The smart soft material	1220:1242	The smart soft material that we have developed tackled well-known limitations of these systems and it may prove valuable in future medical diagnostics or treatments	1220:1383	The smart soft material that we have developed tackled well-known limitations of these systems and it may prove valuable in future medical diagnostics or treatments.
34309163	2	5	theme	1,3-benzenediboronic	383:402	arg1	acid					404:407	1,3-benzenediboronic acid	383:407	1,3-benzenediboronic acid (IPN)	383:413	The alginate pores, particularly located at the periphery, were blocked by interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (IPN), thus, significantly reducing uncontrolled leakage of the entrapped biomolecules.
34309163	2	5	theme	1,3-benzenediboronic	383:402	arg1	IPN					410:412	IPN	410:412	IPN	410:412	The alginate pores, particularly located at the periphery, were blocked by interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (IPN), thus, significantly reducing uncontrolled leakage of the entrapped biomolecules.
34309163	5	6	theme	logic	930:934	arg1	gates					936:940	different logic gates	920:940	different logic gates	920:940	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	8	7	dep	material	1235:1242	arg1	prove					1326:1330	prove	1326:1330	may prove valuable in future medical diagnostics or treatments	1322:1383	The smart soft material that we have developed tackled well-known limitations of these systems and it may prove valuable in future medical diagnostics or treatments.
34309163	8	7	dep	material	1235:1242	arg1	developed					1257:1265	developed	1257:1265	have developed tackled well-known limitations of these systems	1252:1313	The smart soft material that we have developed tackled well-known limitations of these systems and it may prove valuable in future medical diagnostics or treatments.
34309163	4	8	theme	relevant	665:672	arg1	signals					680:686	biologically relevant input signals	652:686	biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1	652:741	The enzymes were activated with biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1, having the production of H2 O2 as the result of the biocatalytic reactions.
34309163	5	9	theme	H2	885:886	arg1	production					891:900	the H2 O2 production	881:900	the H2 O2 production	881:900	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	1	10	used	used	188:191	arg2	hydrogels					115:123	Alginate composite hydrogels	96:123	Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior	96:181	Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior were used for signal-stimulated release of pre-loaded insulin.
34309163	4	11	theme	biocatalytic	796:807	arg1	reactions					809:817	the biocatalytic reactions	792:817	the biocatalytic reactions	792:817	The enzymes were activated with biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1, having the production of H2 O2 as the result of the biocatalytic reactions.
34309163	3	12	theme	Boolean	572:578	arg1	gates					586:590	different Boolean logic gates	562:590	different Boolean logic gates (AND, OR, NOR, IMP, INHIB)	562:617	The beads were loaded with insulin and various enzymes mimicking different Boolean logic gates (AND, OR, NOR, IMP, INHIB).
34309163	1	13	theme	signal-stimulated	197:213	arg1	release					215:221	signal-stimulated release	197:221	signal-stimulated release of pre-loaded insulin	197:243	Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior were used for signal-stimulated release of pre-loaded insulin.
34309163	0	14	from	Hydrogels	44:52	arg1	Release					12:18	Biomolecule Release	0:18	Biomolecule Release from Alginate Composite Hydrogels Triggered by Logically Processed Signals.	0:94	Biomolecule Release from Alginate Composite Hydrogels Triggered by Logically Processed Signals.
34309163	8	15	theme	tackled	1267:1273	arg1	limitations					1286:1296	tackled well-known limitations	1267:1296	tackled well-known limitations of these systems	1267:1313	The smart soft material that we have developed tackled well-known limitations of these systems and it may prove valuable in future medical diagnostics or treatments.
34309163	0	16	theme	Biomolecule	0:10	arg1	Release					12:18	Biomolecule Release	0:18	Biomolecule Release from Alginate Composite Hydrogels Triggered by Logically Processed Signals.	0:94	Biomolecule Release from Alginate Composite Hydrogels Triggered by Logically Processed Signals.
34309163	2	17	theme	biomolecules	483:494	arg1	leakage					458:464	uncontrolled leakage	445:464	uncontrolled leakage of the entrapped biomolecules	445:494	The alginate pores, particularly located at the periphery, were blocked by interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (IPN), thus, significantly reducing uncontrolled leakage of the entrapped biomolecules.
34309163	5	18	theme	input	856:860	arg1	signals					862:868	the input signals	852:868	the input signals leading to the H2 O2 production	852:900	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	1	19	theme	Alginate	96:103	arg1	hydrogels					115:123	Alginate composite hydrogels	96:123	Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior	96:181	Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior were used for signal-stimulated release of pre-loaded insulin.
34309163	5	20	theme	successful	825:834	arg1	combination					837:847	The "successful" combination	820:847	The "successful" combination of the input signals leading to the H2 O2 production	820:900	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	5	20	theme	successful	825:834	arg1	different					906:914	different	906:914	different	906:914	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	2	21	theme	entrapped	473:481	arg1	biomolecules					483:494	the entrapped biomolecules	469:494	the entrapped biomolecules	469:494	The alginate pores, particularly located at the periphery, were blocked by interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (IPN), thus, significantly reducing uncontrolled leakage of the entrapped biomolecules.
34309163	4	22	theme	reactions	809:817	arg1	production					755:764	the production	751:764	the production of H2 O2	751:773	The enzymes were activated with biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1, having the production of H2 O2 as the result of the biocatalytic reactions.
34309163	4	22	theme	reactions	809:817	arg1	result					782:787	the result	778:787	the result of the biocatalytic reactions	778:817	The enzymes were activated with biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1, having the production of H2 O2 as the result of the biocatalytic reactions.
34309163	1	23	theme	composite	105:113	arg1	hydrogels					115:123	Alginate composite hydrogels	96:123	Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior	96:181	Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior were used for signal-stimulated release of pre-loaded insulin.
34309163	8	24	theme	well-known	1275:1284	arg1	limitations					1286:1296	tackled well-known limitations	1267:1296	tackled well-known limitations of these systems	1267:1313	The smart soft material that we have developed tackled well-known limitations of these systems and it may prove valuable in future medical diagnostics or treatments.
34309163	1	25	theme	pre-loaded	226:235	arg1	insulin					237:243	pre-loaded insulin	226:243	pre-loaded insulin	226:243	Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior were used for signal-stimulated release of pre-loaded insulin.
34309163	0	26	theme	Alginate	25:32	arg1	Hydrogels					44:52	Alginate Composite Hydrogels	25:52	Alginate Composite Hydrogels	25:52	Biomolecule Release from Alginate Composite Hydrogels Triggered by Logically Processed Signals.
34309163	8	27	theme	smart	1224:1228	arg1	material					1235:1242	The smart soft material	1220:1242	The smart soft material that we have developed tackled well-known limitations of these systems and it may prove valuable in future medical diagnostics or treatments	1220:1383	The smart soft material that we have developed tackled well-known limitations of these systems and it may prove valuable in future medical diagnostics or treatments.
34309163	2	28	theme	polyvinyl	341:349	arg1	PVA					360:362	PVA	360:362	PVA	360:362	The alginate pores, particularly located at the periphery, were blocked by interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (IPN), thus, significantly reducing uncontrolled leakage of the entrapped biomolecules.
34309163	2	28	theme	polyvinyl	341:349	arg1	alcohol					351:357	polyvinyl alcohol	341:357	polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (IPN)	341:413	The alginate pores, particularly located at the periphery, were blocked by interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (IPN), thus, significantly reducing uncontrolled leakage of the entrapped biomolecules.
34309163	5	29	theme	corresponding	957:969	arg1	tables					977:982	the corresponding truth tables	953:982	the corresponding truth tables of the logic gates	953:1001	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	1	30	theme	insulin	237:243	arg1	release					215:221	signal-stimulated release	197:221	signal-stimulated release of pre-loaded insulin	197:243	Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior were used for signal-stimulated release of pre-loaded insulin.
34309163	2	31	theme	alcohol	351:357	arg1	interpenetration					321:336	interpenetration	321:336	interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (IPN)	321:413	The alginate pores, particularly located at the periphery, were blocked by interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (IPN), thus, significantly reducing uncontrolled leakage of the entrapped biomolecules.
34309163	5	32	theme	different	920:928	arg1	gates					936:940	different logic gates	920:940	different logic gates	920:940	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	4	33	dep	combinations	710:721	arg1	0,0					724:726	0,0	724:726	0,0	724:726	The enzymes were activated with biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1, having the production of H2 O2 as the result of the biocatalytic reactions.
34309163	2	34	theme	uncontrolled	445:456	arg1	leakage					458:464	uncontrolled leakage	445:464	uncontrolled leakage of the entrapped biomolecules	445:494	The alginate pores, particularly located at the periphery, were blocked by interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (IPN), thus, significantly reducing uncontrolled leakage of the entrapped biomolecules.
34309163	7	35	theme	alginate	1204:1211	arg1	beads					1213:1217	the alginate beads	1200:1217	the alginate beads	1200:1217	This process allowed release of insulin from the alginate beads.
34309163	2	36	theme	located	279:285	arg1	pores					259:263	The alginate pores	246:263	The alginate pores	246:263	The alginate pores, particularly located at the periphery, were blocked by interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (IPN), thus, significantly reducing uncontrolled leakage of the entrapped biomolecules.
34309163	2	37	from	periphery	294:302	arg1	located					279:285	located	279:285	located	279:285	The alginate pores, particularly located at the periphery, were blocked by interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (IPN), thus, significantly reducing uncontrolled leakage of the entrapped biomolecules.
34309163	0	38	theme	Composite	34:42	arg1	Hydrogels					44:52	Alginate Composite Hydrogels	25:52	Alginate Composite Hydrogels	25:52	Biomolecule Release from Alginate Composite Hydrogels Triggered by Logically Processed Signals.
34309163	5	39	theme	truth	971:975	arg1	tables					977:982	the corresponding truth tables	953:982	the corresponding truth tables of the logic gates	953:1001	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	7	40	from	beads	1213:1217	arg1	release					1176:1182	release	1176:1182	release of insulin from the alginate beads	1176:1217	This process allowed release of insulin from the alginate beads.
34309163	6	41	theme	hydrogel	1145:1152	arg1	pores					1132:1136	the original pores	1119:1136	the original pores of the hydrogel	1119:1152	When H2 O2 was produced, boronate ester bonds were oxidized and the IPN was irreversibly degraded, thus re-opening the original pores of the hydrogel.
34309163	5	42	theme	signals	862:868	arg1	combination					837:847	The "successful" combination	820:847	The "successful" combination of the input signals leading to the H2 O2 production	820:900	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	5	42	theme	signals	862:868	arg1	different					906:914	different	906:914	different	906:914	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	2	43	theme	alginate	250:257	arg1	pores					259:263	The alginate pores	246:263	The alginate pores	246:263	The alginate pores, particularly located at the periphery, were blocked by interpenetration of polyvinyl alcohol (PVA) cross-linked with 1,3-benzenediboronic acid (IPN), thus, significantly reducing uncontrolled leakage of the entrapped biomolecules.
34309163	4	44	theme	input	674:678	arg1	signals					680:686	biologically relevant input signals	652:686	biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1	652:741	The enzymes were activated with biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1, having the production of H2 O2 as the result of the biocatalytic reactions.
34309163	8	45	theme	future	1344:1349	arg1	diagnostics					1359:1369	future medical diagnostics	1344:1369	future medical diagnostics	1344:1369	The smart soft material that we have developed tackled well-known limitations of these systems and it may prove valuable in future medical diagnostics or treatments.
34309163	5	46	theme	logic	991:995	arg1	gates					997:1001	the logic gates	987:1001	the logic gates	987:1001	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	1	47	theme	sensitive	145:153	arg1	behavior					174:181	highly sensitive stimuli-responsive behavior	138:181	highly sensitive stimuli-responsive behavior	138:181	Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior were used for signal-stimulated release of pre-loaded insulin.
34309163	5	48	theme	"	835:835	arg1	combination					837:847	The "successful" combination	820:847	The "successful" combination of the input signals leading to the H2 O2 production	820:900	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	5	48	theme	"	835:835	arg1	different					906:914	different	906:914	different	906:914	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	3	49	theme	logic	580:584	arg1	gates					586:590	different Boolean logic gates	562:590	different Boolean logic gates (AND, OR, NOR, IMP, INHIB)	562:617	The beads were loaded with insulin and various enzymes mimicking different Boolean logic gates (AND, OR, NOR, IMP, INHIB).
34309163	5	50	theme	gates	997:1001	arg1	tables					977:982	the corresponding truth tables	953:982	the corresponding truth tables of the logic gates	953:1001	The "successful" combination of the input signals leading to the H2 O2 production was different for different logic gates, following the corresponding truth tables of the logic gates.
34309163	1	51	theme	stimuli-responsive	155:172	arg1	behavior					174:181	highly sensitive stimuli-responsive behavior	138:181	highly sensitive stimuli-responsive behavior	138:181	Alginate composite hydrogels that exhibit highly sensitive stimuli-responsive behavior were used for signal-stimulated release of pre-loaded insulin.
34309163	3	52	dep	gates	586:590	arg1	IMP					607:609	IMP	607:609	IMP	607:609	The beads were loaded with insulin and various enzymes mimicking different Boolean logic gates (AND, OR, NOR, IMP, INHIB).
34309163	3	52	dep	gates	586:590	arg1	OR					598:599	OR	598:599	OR	598:599	The beads were loaded with insulin and various enzymes mimicking different Boolean logic gates (AND, OR, NOR, IMP, INHIB).
34309163	3	52	dep	gates	586:590	arg1	INHIB					612:616	INHIB	612:616	INHIB	612:616	The beads were loaded with insulin and various enzymes mimicking different Boolean logic gates (AND, OR, NOR, IMP, INHIB).
34309163	0	53	theme	Processed	77:85	arg1	Signals					87:93	Logically Processed Signals	67:93	Logically Processed Signals	67:93	Biomolecule Release from Alginate Composite Hydrogels Triggered by Logically Processed Signals.
34309163	6	54	theme	boronate	1029:1036	arg1	bonds					1044:1048	boronate ester bonds	1029:1048	boronate ester bonds	1029:1048	When H2 O2 was produced, boronate ester bonds were oxidized and the IPN was irreversibly degraded, thus re-opening the original pores of the hydrogel.
34309163	6	55	theme	original	1123:1130	arg1	pores					1132:1136	the original pores	1119:1136	the original pores of the hydrogel	1119:1152	When H2 O2 was produced, boronate ester bonds were oxidized and the IPN was irreversibly degraded, thus re-opening the original pores of the hydrogel.
34309163	6	56	theme	ester	1038:1042	arg1	bonds					1044:1048	boronate ester bonds	1029:1048	boronate ester bonds	1029:1048	When H2 O2 was produced, boronate ester bonds were oxidized and the IPN was irreversibly degraded, thus re-opening the original pores of the hydrogel.
34309163	8	57	theme	systems	1307:1313	arg1	limitations					1286:1296	tackled well-known limitations	1267:1296	tackled well-known limitations of these systems	1267:1313	The smart soft material that we have developed tackled well-known limitations of these systems and it may prove valuable in future medical diagnostics or treatments.
34309163	4	58	theme	H2	769:770	arg1	production					755:764	the production	751:764	the production of H2 O2	751:773	The enzymes were activated with biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1, having the production of H2 O2 as the result of the biocatalytic reactions.
34309163	4	58	theme	H2	769:770	arg1	result					782:787	the result	778:787	the result of the biocatalytic reactions	778:817	The enzymes were activated with biologically relevant input signals applied in four logic combinations: 0,0; 1,0; 0,1; 1,1, having the production of H2 O2 as the result of the biocatalytic reactions.
34309163	7	59	theme	insulin	1187:1193	arg1	release					1176:1182	release	1176:1182	release of insulin from the alginate beads	1176:1217	This process allowed release of insulin from the alginate beads.
34309163	3	60	theme	different	562:570	arg1	gates					586:590	different Boolean logic gates	562:590	different Boolean logic gates (AND, OR, NOR, IMP, INHIB)	562:617	The beads were loaded with insulin and various enzymes mimicking different Boolean logic gates (AND, OR, NOR, IMP, INHIB).
35006713	0	0	theme	Antimicrobial	65:77	arg1	Activity					79:86	Antimicrobial Activity	65:86	Antimicrobial Activity	65:86	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.
35006713	3	1	theme	MWAP-modified	572:584	arg1	surface					590:596	this MWAP-modified PLA surface	567:596	this MWAP-modified PLA surface	567:596	First, an atmospheric plasma (MWAP) torch was used to modify the PLA surface in less than 5 min in order to create enough activated sites toward the chitosan adhesion, followed by a direct dip coating to spread and immobilize chitosan on this MWAP-modified PLA surface.
35006713	4	2	theme	atomic	728:733	arg1	microscopy					741:750	atomic force microscopy	728:750	atomic force microscopy	728:750	The modification of the PLA surface properties was confirmed by X-ray photoelectron spectroscopy (XPS), water contact angle, and atomic force microscopy.
35006713	7	3	theme	XPS	1077:1079	arg1	results					1081:1087	Our XPS results	1073:1087	Our XPS results	1073:1087	Our XPS results bring us the hypothesis that the stabilization of the chitosan layer is mainly induced by noncovalent interactions such as hydrogen bonding and electrostatic interactions.
35006713	8	4	theme	biological	1286:1295	arg1	properties					1297:1306	the biological properties	1282:1306	the biological properties of theses surfaces	1282:1325	A first insight into the biological properties of theses surfaces was assessed in terms of the antimicrobial activity of the here-designed surfaces.
35006713	1	5	theme	fast	270:273	arg1	manner					275:280	a fast manner	268:280	a fast manner	268:280	In this study, a simple method to immobilize chitosan on a poly(lactic acid) (PLA) surface was developed in a fast manner.
35006713	1	6	theme	poly	219:222	arg1	surface					243:249	a poly(lactic acid) (PLA) surface	217:249	a poly(lactic acid) (PLA) surface	217:249	In this study, a simple method to immobilize chitosan on a poly(lactic acid) (PLA) surface was developed in a fast manner.
35006713	1	7	dep	method	184:189	arg1	immobilize					194:203	immobilize	194:203	to immobilize chitosan on a poly(lactic acid) (PLA) surface	191:249	In this study, a simple method to immobilize chitosan on a poly(lactic acid) (PLA) surface was developed in a fast manner.
35006713	4	8	theme	properties	635:644	arg1	modification					603:614	The modification	599:614	The modification of the PLA surface properties	599:644	The modification of the PLA surface properties was confirmed by X-ray photoelectron spectroscopy (XPS), water contact angle, and atomic force microscopy.
35006713	5	9	theme	carboxylic	842:851	arg1	moieties					858:865	carboxylic acid moieties	842:865	carboxylic acid moieties	842:865	It resulted that the activated species derived from the plasma torch, i.e., hydroxyl and carboxylic acid moieties, enabled an increase of the hydrophilicity of the PLA surface.
35006713	4	10	theme	force	735:739	arg1	microscopy					741:750	atomic force microscopy	728:750	atomic force microscopy	728:750	The modification of the PLA surface properties was confirmed by X-ray photoelectron spectroscopy (XPS), water contact angle, and atomic force microscopy.
35006713	4	11	theme	surface	627:633	arg1	properties					635:644	the PLA surface properties	619:644	the PLA surface properties	619:644	The modification of the PLA surface properties was confirmed by X-ray photoelectron spectroscopy (XPS), water contact angle, and atomic force microscopy.
35006713	1	12	theme	lactic	224:229	arg1	poly					219:222	a poly	217:222	a poly(lactic acid) (PLA) surface	217:249	In this study, a simple method to immobilize chitosan on a poly(lactic acid) (PLA) surface was developed in a fast manner.
35006713	1	12	theme	lactic	224:229	arg1	acid					231:234	lactic acid	224:234	lactic acid	224:234	In this study, a simple method to immobilize chitosan on a poly(lactic acid) (PLA) surface was developed in a fast manner.
35006713	0	13	theme	Chitosan	102:109	arg1	Immobilization					111:124	Direct Chitosan Immobilization	95:124	Direct Chitosan Immobilization onto Poly(lactic acid) Substrate	95:157	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.
35006713	8	14	theme	activity	1370:1377	arg1	terms					1343:1347	terms	1343:1347	terms of the antimicrobial activity of the here-designed surfaces	1343:1407	A first insight into the biological properties of theses surfaces was assessed in terms of the antimicrobial activity of the here-designed surfaces.
35006713	4	15	theme	contact	709:715	arg1	angle					717:721	water contact angle	703:721	water contact angle	703:721	The modification of the PLA surface properties was confirmed by X-ray photoelectron spectroscopy (XPS), water contact angle, and atomic force microscopy.
35006713	5	16	dep	hydroxyl	829:836	arg1	i.e.					823:826	i.e.	823:826	i.e.	823:826	It resulted that the activated species derived from the plasma torch, i.e., hydroxyl and carboxylic acid moieties, enabled an increase of the hydrophilicity of the PLA surface.
35006713	6	17	theme	dip	1018:1020	arg1	coating					1022:1028	dip coating	1018:1028	dip coating	1018:1028	Interestingly, this activated surface allows a good spreading of chitosan solution from dip coating and leads to a homogeneous stable coating.
35006713	7	18	theme	layer	1152:1156	arg1	stabilization					1122:1134	the stabilization	1118:1134	the stabilization of the chitosan layer	1118:1156	Our XPS results bring us the hypothesis that the stabilization of the chitosan layer is mainly induced by noncovalent interactions such as hydrogen bonding and electrostatic interactions.
35006713	0	19	theme	Direct	95:100	arg1	Immobilization					111:124	Direct Chitosan Immobilization	95:124	Direct Chitosan Immobilization onto Poly(lactic acid) Substrate	95:157	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.
35006713	3	20	theme	PLA	586:588	arg1	surface					590:596	this MWAP-modified PLA surface	567:596	this MWAP-modified PLA surface	567:596	First, an atmospheric plasma (MWAP) torch was used to modify the PLA surface in less than 5 min in order to create enough activated sites toward the chitosan adhesion, followed by a direct dip coating to spread and immobilize chitosan on this MWAP-modified PLA surface.
35006713	3	21	from	chitosan	555:562	arg1	surface					590:596	this MWAP-modified PLA surface	567:596	this MWAP-modified PLA surface	567:596	First, an atmospheric plasma (MWAP) torch was used to modify the PLA surface in less than 5 min in order to create enough activated sites toward the chitosan adhesion, followed by a direct dip coating to spread and immobilize chitosan on this MWAP-modified PLA surface.
35006713	3	22	theme	MWAP	359:362	arg1	torch					365:369	an atmospheric plasma (MWAP) torch	336:369	an atmospheric plasma (MWAP) torch	336:369	First, an atmospheric plasma (MWAP) torch was used to modify the PLA surface in less than 5 min in order to create enough activated sites toward the chitosan adhesion, followed by a direct dip coating to spread and immobilize chitosan on this MWAP-modified PLA surface.
35006713	0	23	theme	Atmospheric	10:20	arg1	Plasma					22:27	Microwave Atmospheric Plasma	0:27	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.	0:158	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.
35006713	8	24	theme	first	1263:1267	arg1	insight					1269:1275	A first insight	1261:1275	A first insight into the biological properties of theses surfaces	1261:1325	A first insight into the biological properties of theses surfaces was assessed in terms of the antimicrobial activity of the here-designed surfaces.
35006713	6	25	theme	solution	1004:1011	arg1	spreading					982:990	a good spreading	975:990	a good spreading of chitosan solution from dip coating	975:1028	Interestingly, this activated surface allows a good spreading of chitosan solution from dip coating and leads to a homogeneous stable coating.
35006713	6	26	from	coating	1022:1028	arg1	spreading					982:990	a good spreading	975:990	a good spreading of chitosan solution from dip coating	975:1028	Interestingly, this activated surface allows a good spreading of chitosan solution from dip coating and leads to a homogeneous stable coating.
35006713	3	27	theme	atmospheric	339:349	arg1	torch					365:369	an atmospheric plasma (MWAP) torch	336:369	an atmospheric plasma (MWAP) torch	336:369	First, an atmospheric plasma (MWAP) torch was used to modify the PLA surface in less than 5 min in order to create enough activated sites toward the chitosan adhesion, followed by a direct dip coating to spread and immobilize chitosan on this MWAP-modified PLA surface.
35006713	0	28	theme	Microwave	0:8	arg1	Plasma					22:27	Microwave Atmospheric Plasma	0:27	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.	0:158	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.
35006713	3	29	theme	activated	451:459	arg1	sites					461:465	enough activated sites	444:465	enough activated sites toward the chitosan adhesion, followed by a direct dip coating to spread	444:538	First, an atmospheric plasma (MWAP) torch was used to modify the PLA surface in less than 5 min in order to create enough activated sites toward the chitosan adhesion, followed by a direct dip coating to spread and immobilize chitosan on this MWAP-modified PLA surface.
35006713	3	30	theme	plasma	351:356	arg1	torch					365:369	an atmospheric plasma (MWAP) torch	336:369	an atmospheric plasma (MWAP) torch	336:369	First, an atmospheric plasma (MWAP) torch was used to modify the PLA surface in less than 5 min in order to create enough activated sites toward the chitosan adhesion, followed by a direct dip coating to spread and immobilize chitosan on this MWAP-modified PLA surface.
35006713	8	31	theme	surfaces	1400:1407	arg1	activity					1370:1377	the antimicrobial activity	1352:1377	the antimicrobial activity of the here-designed surfaces	1352:1407	A first insight into the biological properties of theses surfaces was assessed in terms of the antimicrobial activity of the here-designed surfaces.
35006713	7	32	theme	hydrogen	1212:1219	arg1	bonding					1221:1227	hydrogen bonding	1212:1227	hydrogen bonding	1212:1227	Our XPS results bring us the hypothesis that the stabilization of the chitosan layer is mainly induced by noncovalent interactions such as hydrogen bonding and electrostatic interactions.
35006713	3	33	used	used	375:378	arg2	torch					365:369	an atmospheric plasma (MWAP) torch	336:369	an atmospheric plasma (MWAP) torch	336:369	First, an atmospheric plasma (MWAP) torch was used to modify the PLA surface in less than 5 min in order to create enough activated sites toward the chitosan adhesion, followed by a direct dip coating to spread and immobilize chitosan on this MWAP-modified PLA surface.
35006713	6	34	theme	chitosan	995:1002	arg1	solution					1004:1011	chitosan solution	995:1011	chitosan solution	995:1011	Interestingly, this activated surface allows a good spreading of chitosan solution from dip coating and leads to a homogeneous stable coating.
35006713	3	35	theme	dip	518:520	arg1	coating					522:528	a direct dip coating	509:528	a direct dip coating to spread	509:538	First, an atmospheric plasma (MWAP) torch was used to modify the PLA surface in less than 5 min in order to create enough activated sites toward the chitosan adhesion, followed by a direct dip coating to spread and immobilize chitosan on this MWAP-modified PLA surface.
35006713	0	36	dep	Way	51:53	arg1	Confer					58:63	Confer	58:63	to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate	55:157	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.
35006713	7	37	theme	chitosan	1143:1150	arg1	layer					1152:1156	the chitosan layer	1139:1156	the chitosan layer	1139:1156	Our XPS results bring us the hypothesis that the stabilization of the chitosan layer is mainly induced by noncovalent interactions such as hydrogen bonding and electrostatic interactions.
35006713	0	38	theme	Versatile	32:40	arg1	Way					51:53	A Versatile and Fast Way	30:53	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.	0:158	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.
35006713	5	39	theme	activated	774:782	arg1	species					784:790	the activated species	770:790	the activated species	770:790	It resulted that the activated species derived from the plasma torch, i.e., hydroxyl and carboxylic acid moieties, enabled an increase of the hydrophilicity of the PLA surface.
35006713	5	40	theme	PLA	917:919	arg1	surface					921:927	the PLA surface	913:927	the PLA surface	913:927	It resulted that the activated species derived from the plasma torch, i.e., hydroxyl and carboxylic acid moieties, enabled an increase of the hydrophilicity of the PLA surface.
35006713	7	41	theme	electrostatic	1233:1245	arg1	interactions					1247:1258	electrostatic interactions	1233:1258	electrostatic interactions	1233:1258	Our XPS results bring us the hypothesis that the stabilization of the chitosan layer is mainly induced by noncovalent interactions such as hydrogen bonding and electrostatic interactions.
35006713	1	42	theme	simple	177:182	arg1	method					184:189	a simple method	175:189	a simple method to immobilize chitosan on a poly(lactic acid) (PLA) surface	175:249	In this study, a simple method to immobilize chitosan on a poly(lactic acid) (PLA) surface was developed in a fast manner.
35006713	0	43	theme	Poly	131:134	arg1	Substrate					149:157	Poly(lactic acid) Substrate	131:157	Poly(lactic acid) Substrate	131:157	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.
35006713	5	44	theme	surface	921:927	arg1	hydrophilicity					895:908	the hydrophilicity	891:908	the hydrophilicity of the PLA surface	891:927	It resulted that the activated species derived from the plasma torch, i.e., hydroxyl and carboxylic acid moieties, enabled an increase of the hydrophilicity of the PLA surface.
35006713	3	45	theme	chitosan	478:485	arg1	adhesion					487:494	the chitosan adhesion	474:494	the chitosan adhesion	474:494	First, an atmospheric plasma (MWAP) torch was used to modify the PLA surface in less than 5 min in order to create enough activated sites toward the chitosan adhesion, followed by a direct dip coating to spread and immobilize chitosan on this MWAP-modified PLA surface.
35006713	0	46	theme	Fast	46:49	arg1	Way					51:53	A Versatile and Fast Way	30:53	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.	0:158	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.
35006713	1	47	from	chitosan	205:212	arg1	surface					243:249	a poly(lactic acid) (PLA) surface	217:249	a poly(lactic acid) (PLA) surface	217:249	In this study, a simple method to immobilize chitosan on a poly(lactic acid) (PLA) surface was developed in a fast manner.
35006713	3	48	theme	direct	511:516	arg1	coating					522:528	a direct dip coating	509:528	a direct dip coating to spread	509:538	First, an atmospheric plasma (MWAP) torch was used to modify the PLA surface in less than 5 min in order to create enough activated sites toward the chitosan adhesion, followed by a direct dip coating to spread and immobilize chitosan on this MWAP-modified PLA surface.
35006713	8	49	theme	here-designed	1386:1398	arg1	surfaces					1400:1407	the here-designed surfaces	1382:1407	the here-designed surfaces	1382:1407	A first insight into the biological properties of theses surfaces was assessed in terms of the antimicrobial activity of the here-designed surfaces.
35006713	6	50	theme	good	977:980	arg1	spreading					982:990	a good spreading	975:990	a good spreading of chitosan solution from dip coating	975:1028	Interestingly, this activated surface allows a good spreading of chitosan solution from dip coating and leads to a homogeneous stable coating.
35006713	5	51	theme	plasma	809:814	arg1	torch					816:820	the plasma torch	805:820	the plasma torch	805:820	It resulted that the activated species derived from the plasma torch, i.e., hydroxyl and carboxylic acid moieties, enabled an increase of the hydrophilicity of the PLA surface.
35006713	0	52	theme	lactic	136:141	arg1	Poly					131:134	Poly	131:134	Poly(lactic acid) Substrate	131:157	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.
35006713	0	52	theme	lactic	136:141	arg1	acid					143:146	lactic acid	136:146	lactic acid	136:146	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.
35006713	4	53	theme	water	703:707	arg1	angle					717:721	water contact angle	703:721	water contact angle	703:721	The modification of the PLA surface properties was confirmed by X-ray photoelectron spectroscopy (XPS), water contact angle, and atomic force microscopy.
35006713	3	54	theme	PLA	394:396	arg1	surface					398:404	the PLA surface	390:404	the PLA surface	390:404	First, an atmospheric plasma (MWAP) torch was used to modify the PLA surface in less than 5 min in order to create enough activated sites toward the chitosan adhesion, followed by a direct dip coating to spread and immobilize chitosan on this MWAP-modified PLA surface.
35006713	7	55	theme	noncovalent	1179:1189	arg1	interactions					1191:1202	noncovalent interactions	1179:1202	noncovalent interactions such as hydrogen bonding and electrostatic interactions	1179:1258	Our XPS results bring us the hypothesis that the stabilization of the chitosan layer is mainly induced by noncovalent interactions such as hydrogen bonding and electrostatic interactions.
35006713	7	55	theme	noncovalent	1179:1189	arg1	bonding					1221:1227	hydrogen bonding	1212:1227	hydrogen bonding	1212:1227	Our XPS results bring us the hypothesis that the stabilization of the chitosan layer is mainly induced by noncovalent interactions such as hydrogen bonding and electrostatic interactions.
35006713	7	55	theme	noncovalent	1179:1189	arg1	interactions					1247:1258	electrostatic interactions	1233:1258	electrostatic interactions	1233:1258	Our XPS results bring us the hypothesis that the stabilization of the chitosan layer is mainly induced by noncovalent interactions such as hydrogen bonding and electrostatic interactions.
35006713	6	56	theme	homogeneous	1045:1055	arg1	coating					1064:1070	a homogeneous stable coating	1043:1070	a homogeneous stable coating	1043:1070	Interestingly, this activated surface allows a good spreading of chitosan solution from dip coating and leads to a homogeneous stable coating.
35006713	4	57	theme	X-ray	663:667	arg1	XPS					697:699	XPS	697:699	XPS	697:699	The modification of the PLA surface properties was confirmed by X-ray photoelectron spectroscopy (XPS), water contact angle, and atomic force microscopy.
35006713	4	57	theme	X-ray	663:667	arg1	spectroscopy					683:694	X-ray photoelectron spectroscopy	663:694	X-ray photoelectron spectroscopy (XPS)	663:700	The modification of the PLA surface properties was confirmed by X-ray photoelectron spectroscopy (XPS), water contact angle, and atomic force microscopy.
35006713	6	58	dep	homogeneous	1045:1055	arg1	stable					1057:1062	stable	1057:1062	stable	1057:1062	Interestingly, this activated surface allows a good spreading of chitosan solution from dip coating and leads to a homogeneous stable coating.
35006713	4	59	theme	PLA	623:625	arg1	properties					635:644	the PLA surface properties	619:644	the PLA surface properties	619:644	The modification of the PLA surface properties was confirmed by X-ray photoelectron spectroscopy (XPS), water contact angle, and atomic force microscopy.
35006713	5	60	theme	hydrophilicity	895:908	arg1	increase					879:886	an increase	876:886	an increase of the hydrophilicity of the PLA surface	876:927	It resulted that the activated species derived from the plasma torch, i.e., hydroxyl and carboxylic acid moieties, enabled an increase of the hydrophilicity of the PLA surface.
35006713	0	61	dep	Plasma	22:27	arg1	Way					51:53	A Versatile and Fast Way	30:53	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.	0:158	Microwave Atmospheric Plasma: A Versatile and Fast Way to Confer Antimicrobial Activity toward Direct Chitosan Immobilization onto Poly(lactic acid) Substrate.
35006713	5	62	attach	derived	792:798	arg1	torch					816:820	the plasma torch	805:820	the plasma torch	805:820	It resulted that the activated species derived from the plasma torch, i.e., hydroxyl and carboxylic acid moieties, enabled an increase of the hydrophilicity of the PLA surface.
35006713	5	62	attach	derived	792:798	arg2	species					784:790	the activated species	770:790	the activated species	770:790	It resulted that the activated species derived from the plasma torch, i.e., hydroxyl and carboxylic acid moieties, enabled an increase of the hydrophilicity of the PLA surface.
35006713	8	63	theme	surfaces	1318:1325	arg1	properties					1297:1306	the biological properties	1282:1306	the biological properties of theses surfaces	1282:1325	A first insight into the biological properties of theses surfaces was assessed in terms of the antimicrobial activity of the here-designed surfaces.
35006713	8	64	theme	antimicrobial	1356:1368	arg1	activity					1370:1377	the antimicrobial activity	1352:1377	the antimicrobial activity of the here-designed surfaces	1352:1407	A first insight into the biological properties of theses surfaces was assessed in terms of the antimicrobial activity of the here-designed surfaces.
35006713	5	65	theme	acid	853:856	arg1	moieties					858:865	carboxylic acid moieties	842:865	carboxylic acid moieties	842:865	It resulted that the activated species derived from the plasma torch, i.e., hydroxyl and carboxylic acid moieties, enabled an increase of the hydrophilicity of the PLA surface.
35006713	6	66	theme	activated	950:958	arg1	surface					960:966	this activated surface	945:966	this activated surface	945:966	Interestingly, this activated surface allows a good spreading of chitosan solution from dip coating and leads to a homogeneous stable coating.
35006713	4	67	theme	photoelectron	669:681	arg1	XPS					697:699	XPS	697:699	XPS	697:699	The modification of the PLA surface properties was confirmed by X-ray photoelectron spectroscopy (XPS), water contact angle, and atomic force microscopy.
35006713	4	67	theme	photoelectron	669:681	arg1	spectroscopy					683:694	X-ray photoelectron spectroscopy	663:694	X-ray photoelectron spectroscopy (XPS)	663:700	The modification of the PLA surface properties was confirmed by X-ray photoelectron spectroscopy (XPS), water contact angle, and atomic force microscopy.
34893262	2	0	theme	capable	566:572	arg1	activity					557:564	a photocatalytic activity	540:564	a photocatalytic activity capable of generating •OH from H2O2	540:600	The resultant nanocomposite, termed BC/MoS2, was shown to possess a photocatalytic activity capable of generating •OH from H2O2, while also exhibiting photodynamic/photothermal mechanisms, the combination of which exhibits synergistic activity for the degradation of pollutants as well as for bacterial inactivation.
34893262	2	1	theme	synergistic	697:707	arg1	activity					709:716	synergistic activity	697:716	synergistic activity for the degradation of pollutants as well as for bacterial inactivation	697:788	The resultant nanocomposite, termed BC/MoS2, was shown to possess a photocatalytic activity capable of generating •OH from H2O2, while also exhibiting photodynamic/photothermal mechanisms, the combination of which exhibits synergistic activity for the degradation of pollutants as well as for bacterial inactivation.
34893262	3	2	theme	H2O2	810:813	arg1	presence					798:805	the presence	794:805	the presence of H2O2	794:813	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	5	3	theme	photodegradation	1393:1408	arg1	activity					1410:1417	excellent photodegradation activity	1383:1417	excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde	1383:1561	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	1	4	theme	bacterial	410:418	arg1	cellulose					420:428	bacterial cellulose	410:428	bacterial cellulose	410:428	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	5	5	theme	malachite	1486:1494	arg1	dye					1513:1515	a textile dye	1503:1515	a textile dye	1503:1515	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	5	5	theme	malachite	1486:1494	arg1	green					1496:1500	malachite green	1486:1500	malachite green (a textile dye)	1486:1516	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	1	6	theme	capable	195:201	arg1	materials					185:193	multifunctional water purification materials	150:193	multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams	150:319	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	6	7	theme	wastewater	1679:1688	arg1	treatment					1690:1698	wastewater treatment	1679:1698	wastewater treatment	1679:1698	Taken together, our findings demonstrate that sustainable materials such as BC/MoS2 have potential applications in wastewater treatment and microorganism disinfection.
34893262	2	8	theme	bacterial	767:775	arg1	inactivation					777:788	bacterial inactivation	767:788	bacterial inactivation	767:788	The resultant nanocomposite, termed BC/MoS2, was shown to possess a photocatalytic activity capable of generating •OH from H2O2, while also exhibiting photodynamic/photothermal mechanisms, the combination of which exhibits synergistic activity for the degradation of pollutants as well as for bacterial inactivation.
34893262	3	9	theme	vertical	1097:1104	arg1	100 W					1062:1066	100 W	1062:1066	100 W	1062:1066	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	3	9	theme	vertical	1097:1104	arg1	distance					1106:1113	15 cm vertical distance	1091:1113	15 cm vertical distance	1091:1113	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	4	10	theme	pathogen	1165:1172	arg1	inactivation					1174:1185	synergistic pathogen inactivation	1153:1185	synergistic pathogen inactivation resulting from the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light	1153:1329	Mechanistic studies revealed synergistic pathogen inactivation resulting from the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light.
34893262	3	11	theme	log	908:910	arg1	units					912:916	6 log units	906:916	6 log units	906:916	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	3	11	theme	log	908:910	arg1	%					903:903	99.9999%	896:903	99.9999% (6 log units)	896:917	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	2	12	theme	pollutants	741:750	arg1	degradation					726:736	the degradation	722:736	the degradation of pollutants	722:750	The resultant nanocomposite, termed BC/MoS2, was shown to possess a photocatalytic activity capable of generating •OH from H2O2, while also exhibiting photodynamic/photothermal mechanisms, the combination of which exhibits synergistic activity for the degradation of pollutants as well as for bacterial inactivation.
34893262	4	13	theme	•OH	1250:1252	arg1	combination					1206:1216	the combination	1202:1216	the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light	1202:1329	Mechanistic studies revealed synergistic pathogen inactivation resulting from the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light.
34893262	3	14	theme	aureus	1017:1022	arg1	photoinactivation					927:943	the photoinactivation	923:943	the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus	923:1022	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	6	15	theme	potential	1653:1661	arg1	applications					1663:1674	potential applications	1653:1674	potential applications	1653:1674	Taken together, our findings demonstrate that sustainable materials such as BC/MoS2 have potential applications in wastewater treatment and microorganism disinfection.
34893262	4	16	theme	hyperthermia	1258:1269	arg1	combination					1206:1216	the combination	1202:1216	the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light	1202:1329	Mechanistic studies revealed synergistic pathogen inactivation resulting from the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light.
34893262	5	17	theme	excellent	1383:1391	arg1	activity					1410:1417	excellent photodegradation activity	1383:1417	excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde	1383:1561	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	3	18	dep	illumination	1048:1059	arg1	760 nm ≤ λ ≤ 5000 nm					1069:1088	760 nm ≤ λ ≤ 5000 nm	1069:1088	760 nm ≤ λ ≤ 5000 nm	1069:1088	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	3	18	dep	illumination	1048:1059	arg1	100 W					1062:1066	100 W	1062:1066	100 W	1062:1066	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	3	18	dep	illumination	1048:1059	arg1	distance					1106:1113	15 cm vertical distance	1091:1113	15 cm vertical distance	1091:1113	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	1	19	theme	one-step	436:443	arg1	method					466:471	a one-step in-situ biosynthetic method	434:471	a one-step in-situ biosynthetic method	434:471	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	3	20	theme	efficacy	876:883	arg1	upwards					885:891	excellent antibacterial efficacy upwards	852:891	excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus	852:1022	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	1	21	theme	in-situ	445:451	arg1	method					466:471	a one-step in-situ biosynthetic method	434:471	a one-step in-situ biosynthetic method	434:471	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	2	22	contain	possess	532:538	arg1	nanocomposite					488:500	The resultant nanocomposite	474:500	The resultant nanocomposite	474:500	The resultant nanocomposite, termed BC/MoS2, was shown to possess a photocatalytic activity capable of generating •OH from H2O2, while also exhibiting photodynamic/photothermal mechanisms, the combination of which exhibits synergistic activity for the degradation of pollutants as well as for bacterial inactivation.
34893262	2	22	contain	possess	532:538	arg2	activity					557:564	a photocatalytic activity	540:564	a photocatalytic activity capable of generating •OH from H2O2	540:600	The resultant nanocomposite, termed BC/MoS2, was shown to possess a photocatalytic activity capable of generating •OH from H2O2, while also exhibiting photodynamic/photothermal mechanisms, the combination of which exhibits synergistic activity for the degradation of pollutants as well as for bacterial inactivation.
34893262	5	23	from	contaminants	1438:1449	arg1	presence					1458:1465	the presence	1454:1465	the presence of H2O2	1454:1473	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	3	24	dep	100 W	1062:1066	arg1	5 min					1116:1120	5 min	1116:1120	5 min	1116:1120	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	1	25	theme	organic	216:222	arg1	pollutants					224:233	organic pollutants	216:233	organic pollutants	216:233	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	6	26	contain	have	1648:1651	arg1	BC/MoS2					1640:1646	BC/MoS2	1640:1646	BC/MoS2	1640:1646	Taken together, our findings demonstrate that sustainable materials such as BC/MoS2 have potential applications in wastewater treatment and microorganism disinfection.
34893262	6	26	contain	have	1648:1651	arg2	applications					1663:1674	potential applications	1653:1674	potential applications	1653:1674	Taken together, our findings demonstrate that sustainable materials such as BC/MoS2 have potential applications in wastewater treatment and microorganism disinfection.
34893262	6	26	contain	have	1648:1651	arg1	materials					1622:1630	sustainable materials	1610:1630	sustainable materials such as BC/MoS2	1610:1646	Taken together, our findings demonstrate that sustainable materials such as BC/MoS2 have potential applications in wastewater treatment and microorganism disinfection.
34893262	6	27	theme	microorganism	1704:1716	arg1	disinfection					1718:1729	microorganism disinfection	1704:1729	microorganism disinfection	1704:1729	Taken together, our findings demonstrate that sustainable materials such as BC/MoS2 have potential applications in wastewater treatment and microorganism disinfection.
34893262	0	28	theme	bacterial	14:22	arg1	composites					39:48	bacterial cellulose/MoS2 composites	14:48	bacterial cellulose/MoS2 composites for multi-contaminant wastewater treatment and bacteria inactivation	14:117	In situ grown bacterial cellulose/MoS2 composites for multi-contaminant wastewater treatment and bacteria inactivation.
34893262	1	29	theme	facile	339:344	arg1	method					363:368	a facile and eco-friendly method	337:368	a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method	337:471	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	2	30	theme	photodynamic/photothermal	625:649	arg1	mechanisms					651:660	photodynamic/photothermal mechanisms	625:660	photodynamic/photothermal mechanisms	625:660	The resultant nanocomposite, termed BC/MoS2, was shown to possess a photocatalytic activity capable of generating •OH from H2O2, while also exhibiting photodynamic/photothermal mechanisms, the combination of which exhibits synergistic activity for the degradation of pollutants as well as for bacterial inactivation.
34893262	0	31	dep	treatment	83:91	arg1	inactivation					106:117	inactivation	106:117	inactivation	106:117	In situ grown bacterial cellulose/MoS2 composites for multi-contaminant wastewater treatment and bacteria inactivation.
34893262	4	32	theme	Mechanistic	1124:1134	arg1	studies					1136:1142	Mechanistic studies	1124:1142	Mechanistic studies	1124:1142	Mechanistic studies revealed synergistic pathogen inactivation resulting from the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light.
34893262	3	33	theme	BC/MoS2	820:826	arg1	nanocomposite					828:840	the BC/MoS2 nanocomposite	816:840	the BC/MoS2 nanocomposite	816:840	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	5	34	theme	catechol	1519:1526	arg1	phenol					1538:1543	a phenol	1536:1543	a phenol	1536:1543	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	5	34	theme	catechol	1519:1526	arg1	violet					1528:1533	catechol violet	1519:1533	catechol violet (a phenol)	1519:1544	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	1	35	theme	biosynthetic	453:464	arg1	method					466:471	a one-step in-situ biosynthetic method	434:471	a one-step in-situ biosynthetic method	434:471	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	5	36	theme	H2O2	1470:1473	arg1	presence					1458:1465	the presence	1454:1465	the presence of H2O2	1454:1473	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	3	37	theme	infrared	1029:1036	arg1	lamp					1043:1046	infrared (IR) lamp	1029:1046	infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min)	1029:1121	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	3	37	theme	infrared	1029:1036	arg1	IR					1039:1040	IR	1039:1040	IR	1039:1040	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	2	38	theme	photocatalytic	542:555	arg1	activity					557:564	a photocatalytic activity	540:564	a photocatalytic activity capable of generating •OH from H2O2	540:600	The resultant nanocomposite, termed BC/MoS2, was shown to possess a photocatalytic activity capable of generating •OH from H2O2, while also exhibiting photodynamic/photothermal mechanisms, the combination of which exhibits synergistic activity for the degradation of pollutants as well as for bacterial inactivation.
34893262	1	39	theme	eco-friendly	350:361	arg1	method					363:368	a facile and eco-friendly method	337:368	a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method	337:471	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	4	40	theme	generated	1240:1248	arg1	•OH					1250:1252	•OH	1250:1252	•OH	1250:1252	Mechanistic studies revealed synergistic pathogen inactivation resulting from the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light.
34893262	1	41	theme	inactivating	256:267	arg1	microorganisms					269:282	simultaneously inactivating microorganisms	241:282	simultaneously inactivating microorganisms from contaminated wastewater streams	241:319	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	0	42	theme	cellulose/MoS2	24:37	arg1	composites					39:48	bacterial cellulose/MoS2 composites	14:48	bacterial cellulose/MoS2 composites for multi-contaminant wastewater treatment and bacteria inactivation	14:117	In situ grown bacterial cellulose/MoS2 composites for multi-contaminant wastewater treatment and bacteria inactivation.
34893262	4	43	theme	synergistic	1153:1163	arg1	inactivation					1174:1185	synergistic pathogen inactivation	1153:1185	synergistic pathogen inactivation resulting from the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light	1153:1329	Mechanistic studies revealed synergistic pathogen inactivation resulting from the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light.
34893262	4	44	theme	near-IR	1317:1323	arg1	light					1325:1329	the near-IR light	1313:1329	the near-IR light	1313:1329	Mechanistic studies revealed synergistic pathogen inactivation resulting from the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light.
34893262	2	45	theme	resultant	478:486	arg1	nanocomposite					488:500	The resultant nanocomposite	474:500	The resultant nanocomposite	474:500	The resultant nanocomposite, termed BC/MoS2, was shown to possess a photocatalytic activity capable of generating •OH from H2O2, while also exhibiting photodynamic/photothermal mechanisms, the combination of which exhibits synergistic activity for the degradation of pollutants as well as for bacterial inactivation.
34893262	0	46	theme	multi-contaminant	54:70	arg1	treatment					83:91	multi-contaminant wastewater treatment	54:91	multi-contaminant wastewater treatment	54:91	In situ grown bacterial cellulose/MoS2 composites for multi-contaminant wastewater treatment and bacteria inactivation.
34893262	3	47	theme	excellent	852:860	arg1	upwards					885:891	excellent antibacterial efficacy upwards	852:891	excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus	852:1022	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	3	48	theme	antibacterial	862:874	arg1	upwards					885:891	excellent antibacterial efficacy upwards	852:891	excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus	852:1022	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	1	49	from	streams	313:319	arg1	microorganisms					269:282	simultaneously inactivating microorganisms	241:282	simultaneously inactivating microorganisms from contaminated wastewater streams	241:319	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	3	50	theme	lamp	1043:1046	arg1	illumination					1048:1059	infrared (IR) lamp illumination	1029:1059	infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min)	1029:1121	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	5	51	theme	common	1423:1428	arg1	formaldehyde					1550:1561	formaldehyde	1550:1561	formaldehyde	1550:1561	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	5	51	theme	common	1423:1428	arg1	green					1496:1500	malachite green	1486:1500	malachite green (a textile dye)	1486:1516	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	5	51	theme	common	1423:1428	arg1	contaminants					1438:1449	common aqueous contaminants	1423:1449	common aqueous contaminants	1423:1449	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	5	51	theme	common	1423:1428	arg1	violet					1528:1533	catechol violet	1519:1533	catechol violet (a phenol)	1519:1544	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	1	52	theme	molybdenum	384:393	arg1	disulfide					395:403	molybdenum disulfide	384:403	molybdenum disulfide	384:403	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	4	53	theme	light	1325:1329	arg1	conversion					1299:1308	the photothermal conversion	1282:1308	the photothermal conversion of the near-IR light	1282:1329	Mechanistic studies revealed synergistic pathogen inactivation resulting from the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light.
34893262	5	54	theme	aqueous	1430:1436	arg1	formaldehyde					1550:1561	formaldehyde	1550:1561	formaldehyde	1550:1561	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	5	54	theme	aqueous	1430:1436	arg1	green					1496:1500	malachite green	1486:1500	malachite green (a textile dye)	1486:1516	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	5	54	theme	aqueous	1430:1436	arg1	contaminants					1438:1449	common aqueous contaminants	1423:1449	common aqueous contaminants	1423:1449	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	5	54	theme	aqueous	1430:1436	arg1	violet					1528:1533	catechol violet	1519:1533	catechol violet (a phenol)	1519:1544	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	5	55	theme	BC/MoS2	1349:1355	arg1	nanocomposite					1357:1369	the BC/MoS2 nanocomposite	1345:1369	the BC/MoS2 nanocomposite	1345:1369	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	2	56	theme	mechanisms	651:660	arg1	combination					667:677	the combination	663:677	the combination	663:677	The resultant nanocomposite, termed BC/MoS2, was shown to possess a photocatalytic activity capable of generating •OH from H2O2, while also exhibiting photodynamic/photothermal mechanisms, the combination of which exhibits synergistic activity for the degradation of pollutants as well as for bacterial inactivation.
34893262	4	57	theme	photothermal	1286:1297	arg1	conversion					1299:1308	the photothermal conversion	1282:1308	the photothermal conversion of the near-IR light	1282:1329	Mechanistic studies revealed synergistic pathogen inactivation resulting from the combination of photocatalytically generated •OH and hyperthermia induced by the photothermal conversion of the near-IR light.
34893262	1	58	theme	multifunctional	150:164	arg1	materials					185:193	multifunctional water purification materials	150:193	multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams	150:319	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	1	59	theme	contaminated	289:300	arg1	streams					313:319	contaminated wastewater streams	289:319	contaminated wastewater streams	289:319	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	3	60	theme	15 cm	1091:1095	arg1	100 W					1062:1066	100 W	1062:1066	100 W	1062:1066	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	3	60	theme	15 cm	1091:1095	arg1	distance					1106:1113	15 cm vertical distance	1091:1113	15 cm vertical distance	1091:1113	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	1	61	theme	water	166:170	arg1	materials					185:193	multifunctional water purification materials	150:193	multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams	150:319	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	6	62	theme	sustainable	1610:1620	arg1	BC/MoS2					1640:1646	BC/MoS2	1640:1646	BC/MoS2	1640:1646	Taken together, our findings demonstrate that sustainable materials such as BC/MoS2 have potential applications in wastewater treatment and microorganism disinfection.
34893262	6	62	theme	sustainable	1610:1620	arg1	materials					1622:1630	sustainable materials	1610:1630	sustainable materials such as BC/MoS2	1610:1646	Taken together, our findings demonstrate that sustainable materials such as BC/MoS2 have potential applications in wastewater treatment and microorganism disinfection.
34893262	1	63	theme	wastewater	302:311	arg1	streams					313:319	contaminated wastewater streams	289:319	contaminated wastewater streams	289:319	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	0	64	theme	wastewater	72:81	arg1	treatment					83:91	multi-contaminant wastewater treatment	54:91	multi-contaminant wastewater treatment	54:91	In situ grown bacterial cellulose/MoS2 composites for multi-contaminant wastewater treatment and bacteria inactivation.
34893262	5	65	theme	textile	1505:1511	arg1	dye					1513:1515	a textile dye	1503:1515	a textile dye	1503:1515	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	5	65	theme	textile	1505:1511	arg1	green					1496:1500	malachite green	1486:1500	malachite green (a textile dye)	1486:1516	In addition, the BC/MoS2 nanocomposite also showed excellent photodegradation activity for common aqueous contaminants in the presence of H2O2, including malachite green (a textile dye), catechol violet (a phenol) and formaldehyde.
34893262	1	66	theme	purification	172:183	arg1	materials					185:193	multifunctional water purification materials	150:193	multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams	150:319	For the purpose of developing multifunctional water purification materials capable of degrading organic pollutants while simultaneously inactivating microorganisms from contaminated wastewater streams, we report here a facile and eco-friendly method to immobilize molybdenum disulfide into bacterial cellulose via a one-step in-situ biosynthetic method.
34893262	3	67	theme	coli	979:982	arg1	photoinactivation					927:943	the photoinactivation	923:943	the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus	923:1022	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
34893262	3	68	theme	%	903:903	arg1	upwards					885:891	excellent antibacterial efficacy upwards	852:891	excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus	852:1022	In the presence of H2O2, the BC/MoS2 nanocomposite exhibited excellent antibacterial efficacy upwards of 99.9999% (6 log units) for the photoinactivation of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus upon infrared (IR) lamp illumination (100 W, 760 nm ≤ λ ≤ 5000 nm, 15 cm vertical distance; 5 min).
33856781	3	0	theme	mesenchymal	338:348	arg1	exosomes					374:381	mesenchymal stem cell (MSC)-derived exosomes	338:381	mesenchymal stem cell (MSC)-derived exosomes	338:381	Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues.
33856781	5	1	from	defects	805:811	arg1	rats					816:819	rats	816:819	rats	816:819	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	7	2	theme	endothelial	1137:1147	arg1	EPCs					1167:1170	EPCs	1167:1170	EPCs	1167:1170	Moreover, the in vitro results demonstrated that uMSCEXOs promoted the proliferation, migration, and angiogenic differentiation of endothelial progenitor cells (EPCs) but did not significantly affect the osteogenic differentiation of BMSCs.
33856781	7	2	theme	endothelial	1137:1147	arg1	cells					1160:1164	endothelial progenitor cells	1137:1164	endothelial progenitor cells (EPCs)	1137:1171	Moreover, the in vitro results demonstrated that uMSCEXOs promoted the proliferation, migration, and angiogenic differentiation of endothelial progenitor cells (EPCs) but did not significantly affect the osteogenic differentiation of BMSCs.
33856781	8	3	theme	potential	1318:1326	arg1	messenger					1342:1350	the potential intercellular messenger	1314:1350	the potential intercellular messenger that promoted angiogenesis by upregulating the NOTCH1/DLL4 pathway	1314:1417	Importantly, mechanistic studies revealed that exosomal miR-21 was the potential intercellular messenger that promoted angiogenesis by upregulating the NOTCH1/DLL4 pathway.
33856781	8	3	theme	potential	1318:1326	arg1	miR-21					1303:1308	exosomal miR-21	1294:1308	exosomal miR-21	1294:1308	Importantly, mechanistic studies revealed that exosomal miR-21 was the potential intercellular messenger that promoted angiogenesis by upregulating the NOTCH1/DLL4 pathway.
33856781	9	4	theme	promising	1458:1466	arg1	strategy					1482:1489	a promising exosome-based strategy	1456:1489	a promising exosome-based strategy	1456:1489	In conclusion, our findings exhibit a promising exosome-based strategy in repairing large bone defects through enhanced angiogenesis, which potentially regulated by the miR-21/NOTCH1/DLL4 signaling axis.
33856781	3	5	theme	stem	350:353	arg1	exosomes					374:381	mesenchymal stem cell (MSC)-derived exosomes	338:381	mesenchymal stem cell (MSC)-derived exosomes	338:381	Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues.
33856781	4	6	theme	MSC-derived	519:529	arg1	exosomes					531:538	MSC-derived exosomes	519:538	MSC-derived exosomes	519:538	However, the reports on the application of MSC-derived exosomes in the repair of large bone defects are sparse.
33856781	6	7	theme	histological	834:845	arg1	evaluation					847:856	histological evaluation	834:856	histological evaluation	834:856	Imaging and histological evaluation indicated that the uMSCEXOs/Gel/nHP composites markedly enhanced bone regeneration in vivo, and the uMSCEXOs might play a key role in this process.
33856781	1	8	theme	orthopedic	183:192	arg1	surgeons					194:201	orthopedic surgeons	183:201	orthopedic surgeons	183:201	Repair of large bone defects represents a major challenge for orthopedic surgeons.
33856781	9	9	theme	exosome-based	1468:1480	arg1	strategy					1482:1489	a promising exosome-based strategy	1456:1489	a promising exosome-based strategy	1456:1489	In conclusion, our findings exhibit a promising exosome-based strategy in repairing large bone defects through enhanced angiogenesis, which potentially regulated by the miR-21/NOTCH1/DLL4 signaling axis.
33856781	3	10	theme	-derived	365:372	arg1	exosomes					374:381	mesenchymal stem cell (MSC)-derived exosomes	338:381	mesenchymal stem cell (MSC)-derived exosomes	338:381	Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues.
33856781	9	11	theme	miR-21/NOTCH1/DLL4	1589:1606	arg1	axis					1618:1621	the miR-21/NOTCH1/DLL4 signaling axis	1585:1621	the miR-21/NOTCH1/DLL4 signaling axis	1585:1621	In conclusion, our findings exhibit a promising exosome-based strategy in repairing large bone defects through enhanced angiogenesis, which potentially regulated by the miR-21/NOTCH1/DLL4 signaling axis.
33856781	4	12	from	application	504:514	arg1	repair					547:552	the repair	543:552	the repair of large bone defects	543:574	However, the reports on the application of MSC-derived exosomes in the repair of large bone defects are sparse.
33856781	9	13	theme	signaling	1608:1616	arg1	axis					1618:1621	the miR-21/NOTCH1/DLL4 signaling axis	1585:1621	the miR-21/NOTCH1/DLL4 signaling axis	1585:1621	In conclusion, our findings exhibit a promising exosome-based strategy in repairing large bone defects through enhanced angiogenesis, which potentially regulated by the miR-21/NOTCH1/DLL4 signaling axis.
33856781	3	14	theme	MSC	361:363	arg1	exosomes					374:381	mesenchymal stem cell (MSC)-derived exosomes	338:381	mesenchymal stem cell (MSC)-derived exosomes	338:381	Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues.
33856781	6	15	theme	bone	923:926	arg1	regeneration					928:939	bone regeneration	923:939	bone regeneration	923:939	Imaging and histological evaluation indicated that the uMSCEXOs/Gel/nHP composites markedly enhanced bone regeneration in vivo, and the uMSCEXOs might play a key role in this process.
33856781	3	16	link	-derived	365:372	arg1	exosomes					374:381	mesenchymal stem cell (MSC)-derived exosomes	338:381	mesenchymal stem cell (MSC)-derived exosomes	338:381	Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues.
33856781	9	17	theme	bone	1510:1513	arg1	defects					1515:1521	large bone defects	1504:1521	large bone defects	1504:1521	In conclusion, our findings exhibit a promising exosome-based strategy in repairing large bone defects through enhanced angiogenesis, which potentially regulated by the miR-21/NOTCH1/DLL4 signaling axis.
33856781	5	18	link	MSC-derived	629:639	arg1	uMSCEXOs					651:658	uMSCEXOs	651:658	uMSCEXOs	651:658	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	5	18	link	MSC-derived	629:639	arg1	exosomes					641:648	umbilical MSC-derived exosomes	619:648	umbilical MSC-derived exosomes (uMSCEXOs)	619:659	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	5	19	theme	nanohydroxyapatite/poly-ε-caprolactone	732:769	arg1	scaffolds					777:785	customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds	721:785	customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats	721:819	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	4	20	from	reports	489:495	arg1	application					504:514	the application	500:514	the application of MSC-derived exosomes in the repair of large bone defects	500:574	However, the reports on the application of MSC-derived exosomes in the repair of large bone defects are sparse.
33856781	7	21	theme	cells	1160:1164	arg1	migration					1092:1100	migration	1092:1100	migration	1092:1100	Moreover, the in vitro results demonstrated that uMSCEXOs promoted the proliferation, migration, and angiogenic differentiation of endothelial progenitor cells (EPCs) but did not significantly affect the osteogenic differentiation of BMSCs.
33856781	7	21	theme	cells	1160:1164	arg1	proliferation					1077:1089	proliferation	1077:1089	proliferation	1077:1089	Moreover, the in vitro results demonstrated that uMSCEXOs promoted the proliferation, migration, and angiogenic differentiation of endothelial progenitor cells (EPCs) but did not significantly affect the osteogenic differentiation of BMSCs.
33856781	7	21	theme	cells	1160:1164	arg1	differentiation					1118:1132	angiogenic differentiation	1107:1132	angiogenic differentiation	1107:1132	Moreover, the in vitro results demonstrated that uMSCEXOs promoted the proliferation, migration, and angiogenic differentiation of endothelial progenitor cells (EPCs) but did not significantly affect the osteogenic differentiation of BMSCs.
33856781	8	22	theme	NOTCH1/DLL4	1399:1409	arg1	pathway					1411:1417	the NOTCH1/DLL4 pathway	1395:1417	the NOTCH1/DLL4 pathway	1395:1417	Importantly, mechanistic studies revealed that exosomal miR-21 was the potential intercellular messenger that promoted angiogenesis by upregulating the NOTCH1/DLL4 pathway.
33856781	7	23	dep	in	1020:1021	arg1	vitro					1023:1027	vitro	1023:1027	vitro	1023:1027	Moreover, the in vitro results demonstrated that uMSCEXOs promoted the proliferation, migration, and angiogenic differentiation of endothelial progenitor cells (EPCs) but did not significantly affect the osteogenic differentiation of BMSCs.
33856781	5	24	theme	customized	721:730	arg1	scaffolds					777:785	customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds	721:785	customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats	721:819	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	0	25	theme	Mesenchymal	10:20	arg1	Hydrogels					61:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels	0:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels	0:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels Accelerate Bone Repair by Enhancing Angiogenesis.
33856781	7	26	theme	BMSCs	1240:1244	arg1	differentiation					1221:1235	the osteogenic differentiation	1206:1235	the osteogenic differentiation of BMSCs	1206:1244	Moreover, the in vitro results demonstrated that uMSCEXOs promoted the proliferation, migration, and angiogenic differentiation of endothelial progenitor cells (EPCs) but did not significantly affect the osteogenic differentiation of BMSCs.
33856781	5	27	theme	MSC-derived	629:639	arg1	uMSCEXOs					651:658	uMSCEXOs	651:658	uMSCEXOs	651:658	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	5	27	theme	MSC-derived	629:639	arg1	exosomes					641:648	umbilical MSC-derived exosomes	619:648	umbilical MSC-derived exosomes (uMSCEXOs)	619:659	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	4	28	theme	large	557:561	arg1	defects					568:574	large bone defects	557:574	large bone defects	557:574	However, the reports on the application of MSC-derived exosomes in the repair of large bone defects are sparse.
33856781	6	29	theme	key	980:982	arg1	role					984:987	a key role	978:987	a key role	978:987	Imaging and histological evaluation indicated that the uMSCEXOs/Gel/nHP composites markedly enhanced bone regeneration in vivo, and the uMSCEXOs might play a key role in this process.
33856781	0	30	theme	Umbilical	0:8	arg1	Hydrogels					61:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels	0:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels	0:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels Accelerate Bone Repair by Enhancing Angiogenesis.
33856781	4	31	link	MSC-derived	519:529	arg1	exosomes					531:538	MSC-derived exosomes	519:538	MSC-derived exosomes	519:538	However, the reports on the application of MSC-derived exosomes in the repair of large bone defects are sparse.
33856781	8	32	theme	mechanistic	1260:1270	arg1	studies					1272:1278	mechanistic studies	1260:1278	mechanistic studies	1260:1278	Importantly, mechanistic studies revealed that exosomal miR-21 was the potential intercellular messenger that promoted angiogenesis by upregulating the NOTCH1/DLL4 pathway.
33856781	7	33	theme	progenitor	1149:1158	arg1	EPCs					1167:1170	EPCs	1167:1170	EPCs	1167:1170	Moreover, the in vitro results demonstrated that uMSCEXOs promoted the proliferation, migration, and angiogenic differentiation of endothelial progenitor cells (EPCs) but did not significantly affect the osteogenic differentiation of BMSCs.
33856781	7	33	theme	progenitor	1149:1158	arg1	cells					1160:1164	endothelial progenitor cells	1137:1164	endothelial progenitor cells (EPCs)	1137:1171	Moreover, the in vitro results demonstrated that uMSCEXOs promoted the proliferation, migration, and angiogenic differentiation of endothelial progenitor cells (EPCs) but did not significantly affect the osteogenic differentiation of BMSCs.
33856781	0	34	theme	Cell-Derived	27:38	arg1	Hydrogels					61:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels	0:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels	0:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels Accelerate Bone Repair by Enhancing Angiogenesis.
33856781	5	35	theme	cranial	797:803	arg1	defects					805:811	repair cranial defects	790:811	repair cranial defects in rats	790:819	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	7	36	theme	angiogenic	1107:1116	arg1	differentiation					1118:1132	angiogenic differentiation	1107:1132	angiogenic differentiation	1107:1132	Moreover, the in vitro results demonstrated that uMSCEXOs promoted the proliferation, migration, and angiogenic differentiation of endothelial progenitor cells (EPCs) but did not significantly affect the osteogenic differentiation of BMSCs.
33856781	8	37	theme	exosomal	1294:1301	arg1	messenger					1342:1350	the potential intercellular messenger	1314:1350	the potential intercellular messenger that promoted angiogenesis by upregulating the NOTCH1/DLL4 pathway	1314:1417	Importantly, mechanistic studies revealed that exosomal miR-21 was the potential intercellular messenger that promoted angiogenesis by upregulating the NOTCH1/DLL4 pathway.
33856781	8	37	theme	exosomal	1294:1301	arg1	miR-21					1303:1308	exosomal miR-21	1294:1308	exosomal miR-21	1294:1308	Importantly, mechanistic studies revealed that exosomal miR-21 was the potential intercellular messenger that promoted angiogenesis by upregulating the NOTCH1/DLL4 pathway.
33856781	0	38	theme	Stem	22:25	arg1	Hydrogels					61:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels	0:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels	0:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels Accelerate Bone Repair by Enhancing Angiogenesis.
33856781	4	39	theme	defects	568:574	arg1	repair					547:552	the repair	543:552	the repair of large bone defects	543:574	However, the reports on the application of MSC-derived exosomes in the repair of large bone defects are sparse.
33856781	1	40	theme	large	131:135	arg1	defects					142:148	large bone defects	131:148	large bone defects	131:148	Repair of large bone defects represents a major challenge for orthopedic surgeons.
33856781	9	41	theme	enhanced	1531:1538	arg1	angiogenesis					1540:1551	enhanced angiogenesis	1531:1551	enhanced angiogenesis	1531:1551	In conclusion, our findings exhibit a promising exosome-based strategy in repairing large bone defects through enhanced angiogenesis, which potentially regulated by the miR-21/NOTCH1/DLL4 signaling axis.
33856781	7	42	theme	osteogenic	1210:1219	arg1	differentiation					1221:1235	the osteogenic differentiation	1206:1235	the osteogenic differentiation of BMSCs	1206:1244	Moreover, the in vitro results demonstrated that uMSCEXOs promoted the proliferation, migration, and angiogenic differentiation of endothelial progenitor cells (EPCs) but did not significantly affect the osteogenic differentiation of BMSCs.
33856781	4	43	theme	bone	563:566	arg1	defects					568:574	large bone defects	557:574	large bone defects	557:574	However, the reports on the application of MSC-derived exosomes in the repair of large bone defects are sparse.
33856781	6	44	theme	uMSCEXOs/Gel/nHP	877:892	arg1	composites					894:903	the uMSCEXOs/Gel/nHP composites	873:903	the uMSCEXOs/Gel/nHP composites	873:903	Imaging and histological evaluation indicated that the uMSCEXOs/Gel/nHP composites markedly enhanced bone regeneration in vivo, and the uMSCEXOs might play a key role in this process.
33856781	3	45	theme	multiple	458:465	arg1	tissues					467:473	multiple tissues	458:473	multiple tissues	458:473	Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues.
33856781	0	46	theme	Exosome-Encapsulated	40:59	arg1	Hydrogels					61:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels	0:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels	0:69	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels Accelerate Bone Repair by Enhancing Angiogenesis.
33856781	5	47	theme	repair	790:795	arg1	defects					805:811	repair cranial defects	790:811	repair cranial defects in rats	790:819	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	2	48	theme	crucial	255:261	arg1	role					263:266	a crucial role	253:266	a crucial role	253:266	The newly formed microvessels inside grafts play a crucial role in successful bone tissue engineering.
33856781	7	49	theme	in	1020:1021	arg1	results					1029:1035	the in vitro results	1016:1035	the in vitro results	1016:1035	Moreover, the in vitro results demonstrated that uMSCEXOs promoted the proliferation, migration, and angiogenic differentiation of endothelial progenitor cells (EPCs) but did not significantly affect the osteogenic differentiation of BMSCs.
33856781	3	50	theme	tissues	467:473	arg1	repair					448:453	the repair	444:453	the repair of multiple tissues	444:473	Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues.
33856781	0	51	theme	Bone	82:85	arg1	Repair					87:92	Bone Repair	82:92	Bone Repair	82:92	Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels Accelerate Bone Repair by Enhancing Angiogenesis.
33856781	4	52	theme	exosomes	531:538	arg1	application					504:514	the application	500:514	the application of MSC-derived exosomes in the repair of large bone defects	500:574	However, the reports on the application of MSC-derived exosomes in the repair of large bone defects are sparse.
33856781	5	53	theme	hyaluronic	664:673	arg1	hydrogel					680:687	hyaluronic acid hydrogel	664:687	hyaluronic acid hydrogel (HA-Gel)	664:696	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	5	53	theme	hyaluronic	664:673	arg1	HA-Gel					690:695	HA-Gel	690:695	HA-Gel	690:695	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	1	54	theme	bone	137:140	arg1	defects					142:148	large bone defects	131:148	large bone defects	131:148	Repair of large bone defects represents a major challenge for orthopedic surgeons.
33856781	5	55	theme	acid	675:678	arg1	hydrogel					680:687	hyaluronic acid hydrogel	664:687	hyaluronic acid hydrogel (HA-Gel)	664:696	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	5	55	theme	acid	675:678	arg1	HA-Gel					690:695	HA-Gel	690:695	HA-Gel	690:695	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	5	56	theme	umbilical	619:627	arg1	uMSCEXOs					651:658	uMSCEXOs	651:658	uMSCEXOs	651:658	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	5	56	theme	umbilical	619:627	arg1	exosomes					641:648	umbilical MSC-derived exosomes	619:648	umbilical MSC-derived exosomes (uMSCEXOs)	619:659	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	1	57	theme	defects	142:148	arg1	Repair					121:126	Repair	121:126	Repair of large bone defects	121:148	Repair of large bone defects represents a major challenge for orthopedic surgeons.
33856781	2	58	theme	inside	234:239	arg1	grafts					241:246	The newly formed microvessels inside grafts	204:246	The newly formed microvessels inside grafts	204:246	The newly formed microvessels inside grafts play a crucial role in successful bone tissue engineering.
33856781	2	59	theme	tissue	287:292	arg1	engineering					294:304	successful bone tissue engineering	271:304	successful bone tissue engineering	271:304	The newly formed microvessels inside grafts play a crucial role in successful bone tissue engineering.
33856781	3	60	theme	active	322:327	arg1	role					329:332	an active role	319:332	an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression	319:425	Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues.
33856781	2	61	theme	microvessels	221:232	arg1	grafts					241:246	The newly formed microvessels inside grafts	204:246	The newly formed microvessels inside grafts	204:246	The newly formed microvessels inside grafts play a crucial role in successful bone tissue engineering.
33856781	2	62	theme	bone	282:285	arg1	engineering					294:304	successful bone tissue engineering	271:304	successful bone tissue engineering	271:304	The newly formed microvessels inside grafts play a crucial role in successful bone tissue engineering.
33856781	8	63	theme	intercellular	1328:1340	arg1	messenger					1342:1350	the potential intercellular messenger	1314:1350	the potential intercellular messenger that promoted angiogenesis by upregulating the NOTCH1/DLL4 pathway	1314:1417	Importantly, mechanistic studies revealed that exosomal miR-21 was the potential intercellular messenger that promoted angiogenesis by upregulating the NOTCH1/DLL4 pathway.
33856781	8	63	theme	intercellular	1328:1340	arg1	miR-21					1303:1308	exosomal miR-21	1294:1308	exosomal miR-21	1294:1308	Importantly, mechanistic studies revealed that exosomal miR-21 was the potential intercellular messenger that promoted angiogenesis by upregulating the NOTCH1/DLL4 pathway.
33856781	3	64	theme	cell	355:358	arg1	exosomes					374:381	mesenchymal stem cell (MSC)-derived exosomes	338:381	mesenchymal stem cell (MSC)-derived exosomes	338:381	Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues.
33856781	2	65	theme	formed	214:219	arg1	grafts					241:246	The newly formed microvessels inside grafts	204:246	The newly formed microvessels inside grafts	204:246	The newly formed microvessels inside grafts play a crucial role in successful bone tissue engineering.
33856781	2	66	theme	successful	271:280	arg1	engineering					294:304	successful bone tissue engineering	271:304	successful bone tissue engineering	271:304	The newly formed microvessels inside grafts play a crucial role in successful bone tissue engineering.
33856781	1	67	theme	major	163:167	arg1	challenge					169:177	a major challenge	161:177	a major challenge for orthopedic surgeons	161:201	Repair of large bone defects represents a major challenge for orthopedic surgeons.
33856781	9	68	theme	large	1504:1508	arg1	defects					1515:1521	large bone defects	1504:1521	large bone defects	1504:1521	In conclusion, our findings exhibit a promising exosome-based strategy in repairing large bone defects through enhanced angiogenesis, which potentially regulated by the miR-21/NOTCH1/DLL4 signaling axis.
33856781	3	69	from	role	329:332	arg1	progression					415:425	progression	415:425	progression	415:425	Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues.
33856781	3	69	from	role	329:332	arg1	development					399:409	blood vessel development	386:409	blood vessel development	386:409	Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues.
33856781	5	70	theme	nHP	772:774	arg1	scaffolds					777:785	customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds	721:785	customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats	721:819	In this study, we encapsulated umbilical MSC-derived exosomes (uMSCEXOs) in hyaluronic acid hydrogel (HA-Gel) and combined them with customized nanohydroxyapatite/poly-ε-caprolactone (nHP) scaffolds to repair cranial defects in rats.
33856781	3	71	theme	blood	386:390	arg1	development					399:409	blood vessel development	386:409	blood vessel development	386:409	Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues.
33856781	3	72	theme	vessel	392:397	arg1	development					399:409	blood vessel development	386:409	blood vessel development	386:409	Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues.
33615714	8	0	theme	homo-	973:977	arg1	complexes					998:1006	homo- and hetero-protein complexes	973:1006	homo- and hetero-protein complexes	973:1006	We also show that BP1 can form homo- and hetero-protein complexes with other UGE family members and with UDP-galactose transporters 2 (OsUGT2) and 3 (OsUGT3), which may facilitate the channeling of Gal to polysaccharides and proteoglycans.
33615714	1	1	theme	matrix	228:233	arg1	polysaccharides					235:249	cell wall matrix polysaccharides	218:249	cell wall matrix polysaccharides	218:249	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	0	2	theme	mechanical	64:73	arg1	strength					75:82	mechanical strength	64:82	mechanical strength	64:82	BRITTLE PLANT1 is required for normal cell wall composition and mechanical strength in rice.
33615714	6	3	theme	uronic	767:772	arg1	acids					774:778	uronic acids	767:778	uronic acids	767:778	Moreover, the mutant had altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose.
33615714	6	4	theme	monosaccharides	803:817	arg1	contents					755:762	altered contents	747:762	altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose	747:832	Moreover, the mutant had altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose.
33615714	1	5	theme	polysaccharides	235:249	arg1	biosynthesis					202:213	biosynthesis	202:213	biosynthesis of cell wall matrix polysaccharides and glycoproteins	202:267	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	8	6	theme	hetero-protein	983:996	arg1	complexes					998:1006	homo- and hetero-protein complexes	973:1006	homo- and hetero-protein complexes	973:1006	We also show that BP1 can form homo- and hetero-protein complexes with other UGE family members and with UDP-galactose transporters 2 (OsUGT2) and 3 (OsUGT3), which may facilitate the channeling of Gal to polysaccharides and proteoglycans.
33615714	7	7	theme	cytosolic	923:931	arg1	protein					933:939	a cytosolic protein	921:939	a cytosolic protein	921:939	Map-based cloning demonstrated that OsBP1 encodes a UDP-glucose 4-epimerase (OsUGE2), a cytosolic protein.
33615714	7	7	theme	cytosolic	923:931	arg1	4-epimerase					899:909	a UDP-glucose 4-epimerase	885:909	a UDP-glucose 4-epimerase (OsUGE2)	885:918	Map-based cloning demonstrated that OsBP1 encodes a UDP-glucose 4-epimerase (OsUGE2), a cytosolic protein.
33615714	7	8	theme	Map-based	835:843	arg1	cloning					845:851	Map-based cloning	835:851	Map-based cloning	835:851	Map-based cloning demonstrated that OsBP1 encodes a UDP-glucose 4-epimerase (OsUGE2), a cytosolic protein.
33615714	5	9	theme	homogalacturonan	674:689	arg1	levels					642:647	reduced levels	634:647	reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins	634:719	The mutant culms had reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins.
33615714	1	10	theme	glycoproteins	255:267	arg1	biosynthesis					202:213	biosynthesis	202:213	biosynthesis of cell wall matrix polysaccharides and glycoproteins	202:267	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	9	11	theme	sugar	1246:1250	arg1	composition					1252:1262	sugar composition	1246:1262	sugar composition	1246:1262	Our results demonstrate that BP1 participates in regulating the sugar composition and structure of rice cell walls.
33615714	6	12	theme	altered	747:753	arg1	contents					755:762	altered contents	747:762	altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose	747:832	Moreover, the mutant had altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose.
33615714	2	13	theme	UDP-glucose	270:280	arg1	4-epimerases					282:293	UDP-glucose 4-epimerases	270:293	UDP-glucose 4-epimerases (UGEs)	270:300	UDP-glucose 4-epimerases (UGEs) are NSEs that function in the interconversion of UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal).
33615714	2	13	theme	UDP-glucose	270:280	arg1	UGEs					296:299	UGEs	296:299	UGEs	296:299	UDP-glucose 4-epimerases (UGEs) are NSEs that function in the interconversion of UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal).
33615714	2	13	theme	UDP-glucose	270:280	arg1	NSEs					306:309	NSEs	306:309	NSEs that function in the interconversion of UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal)	306:399	UDP-glucose 4-epimerases (UGEs) are NSEs that function in the interconversion of UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal).
33615714	2	14	theme	UDP-galactose	377:389	arg1	interconversion					332:346	the interconversion	328:346	the interconversion of UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal)	328:399	UDP-glucose 4-epimerases (UGEs) are NSEs that function in the interconversion of UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal).
33615714	4	15	theme	rice	540:543	arg1	mutant					545:550	a brittle plant (bp1) rice mutant	518:550	a brittle plant (bp1) rice mutant that exhibits brittle leaves and culms at all growth stages	518:610	Here, we report a brittle plant (bp1) rice mutant that exhibits brittle leaves and culms at all growth stages.
33615714	3	16	theme	UDP-glucose	415:425	arg1	4-epimerases					427:438	UDP-glucose 4-epimerases	415:438	UDP-glucose 4-epimerases	415:438	The roles of UDP-glucose 4-epimerases in monocots remain unclear due to redundancy in the pathways.
33615714	9	17	theme	cell	1286:1289	arg1	walls					1291:1295	rice cell walls	1281:1295	rice cell walls	1281:1295	Our results demonstrate that BP1 participates in regulating the sugar composition and structure of rice cell walls.
33615714	8	18	theme	UGE	1019:1021	arg1	members					1030:1036	other UGE family members	1013:1036	other UGE family members	1013:1036	We also show that BP1 can form homo- and hetero-protein complexes with other UGE family members and with UDP-galactose transporters 2 (OsUGT2) and 3 (OsUGT3), which may facilitate the channeling of Gal to polysaccharides and proteoglycans.
33615714	0	19	theme	BRITTLE	0:6	arg1	PLANT1					8:13	BRITTLE PLANT1	0:13	BRITTLE PLANT1	0:13	BRITTLE PLANT1 is required for normal cell wall composition and mechanical strength in rice.
33615714	4	20	theme	brittle	520:526	arg1	mutant					545:550	a brittle plant (bp1) rice mutant	518:550	a brittle plant (bp1) rice mutant that exhibits brittle leaves and culms at all growth stages	518:610	Here, we report a brittle plant (bp1) rice mutant that exhibits brittle leaves and culms at all growth stages.
33615714	8	21	theme	other	1013:1017	arg1	members					1030:1036	other UGE family members	1013:1036	other UGE family members	1013:1036	We also show that BP1 can form homo- and hetero-protein complexes with other UGE family members and with UDP-galactose transporters 2 (OsUGT2) and 3 (OsUGT3), which may facilitate the channeling of Gal to polysaccharides and proteoglycans.
33615714	1	22	gly	glycoproteins	255:267	arg1	glycoproteins					255:267	glycoproteins	255:267	glycoproteins	255:267	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	6	23	theme	neutral	781:787	arg1	monosaccharides					803:817	neutral noncellulosic monosaccharides	781:817	neutral noncellulosic monosaccharides	781:817	Moreover, the mutant had altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose.
33615714	1	24	theme	activated	166:174	arg1	donors					182:187	the activated sugar donors	162:187	the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins	162:267	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	8	25	theme	Gal	1140:1142	arg1	channeling					1126:1135	the channeling	1122:1135	the channeling of Gal to polysaccharides and proteoglycans	1122:1179	We also show that BP1 can form homo- and hetero-protein complexes with other UGE family members and with UDP-galactose transporters 2 (OsUGT2) and 3 (OsUGT3), which may facilitate the channeling of Gal to polysaccharides and proteoglycans.
33615714	7	26	theme	UDP-glucose	887:897	arg1	OsBP1					871:875	OsBP1	871:875	OsBP1	871:875	Map-based cloning demonstrated that OsBP1 encodes a UDP-glucose 4-epimerase (OsUGE2), a cytosolic protein.
33615714	7	26	theme	UDP-glucose	887:897	arg1	protein					933:939	a cytosolic protein	921:939	a cytosolic protein	921:939	Map-based cloning demonstrated that OsBP1 encodes a UDP-glucose 4-epimerase (OsUGE2), a cytosolic protein.
33615714	7	26	theme	UDP-glucose	887:897	arg1	OsUGE2					912:917	OsUGE2	912:917	OsUGE2	912:917	Map-based cloning demonstrated that OsBP1 encodes a UDP-glucose 4-epimerase (OsUGE2), a cytosolic protein.
33615714	7	26	theme	UDP-glucose	887:897	arg1	4-epimerase					899:909	a UDP-glucose 4-epimerase	885:909	a UDP-glucose 4-epimerase (OsUGE2)	885:918	Map-based cloning demonstrated that OsBP1 encodes a UDP-glucose 4-epimerase (OsUGE2), a cytosolic protein.
33615714	1	27	theme	sugar	176:180	arg1	donors					182:187	the activated sugar donors	162:187	the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins	162:267	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	9	28	theme	rice	1281:1284	arg1	walls					1291:1295	rice cell walls	1281:1295	rice cell walls	1281:1295	Our results demonstrate that BP1 participates in regulating the sugar composition and structure of rice cell walls.
33615714	8	29	theme	family	1023:1028	arg1	members					1030:1036	other UGE family members	1013:1036	other UGE family members	1013:1036	We also show that BP1 can form homo- and hetero-protein complexes with other UGE family members and with UDP-galactose transporters 2 (OsUGT2) and 3 (OsUGT3), which may facilitate the channeling of Gal to polysaccharides and proteoglycans.
33615714	0	30	from	strength	75:82	arg1	rice					87:90	rice	87:90	rice	87:90	BRITTLE PLANT1 is required for normal cell wall composition and mechanical strength in rice.
33615714	0	31	theme	normal	31:36	arg1	composition					48:58	normal cell wall composition	31:58	normal cell wall composition	31:58	BRITTLE PLANT1 is required for normal cell wall composition and mechanical strength in rice.
33615714	4	32	theme	plant	528:532	arg1	mutant					545:550	a brittle plant (bp1) rice mutant	518:550	a brittle plant (bp1) rice mutant that exhibits brittle leaves and culms at all growth stages	518:610	Here, we report a brittle plant (bp1) rice mutant that exhibits brittle leaves and culms at all growth stages.
33615714	5	33	theme	rhamnogalacturonan	652:669	arg1	levels					642:647	reduced levels	634:647	reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins	634:719	The mutant culms had reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins.
33615714	3	34	theme	4-epimerases	427:438	arg1	roles					406:410	The roles	402:410	The roles of UDP-glucose 4-epimerases in monocots	402:450	The roles of UDP-glucose 4-epimerases in monocots remain unclear due to redundancy in the pathways.
33615714	9	35	theme	walls	1291:1295	arg1	structure					1268:1276	structure	1268:1276	structure	1268:1276	Our results demonstrate that BP1 participates in regulating the sugar composition and structure of rice cell walls.
33615714	9	35	theme	walls	1291:1295	arg1	composition					1252:1262	sugar composition	1246:1262	sugar composition	1246:1262	Our results demonstrate that BP1 participates in regulating the sugar composition and structure of rice cell walls.
33615714	4	36	theme	bp1	535:537	arg1	mutant					545:550	a brittle plant (bp1) rice mutant	518:550	a brittle plant (bp1) rice mutant that exhibits brittle leaves and culms at all growth stages	518:610	Here, we report a brittle plant (bp1) rice mutant that exhibits brittle leaves and culms at all growth stages.
33615714	8	37	dep	transporters	1061:1072	arg1	OsUGT3					1092:1097	OsUGT3	1092:1097	OsUGT3	1092:1097	We also show that BP1 can form homo- and hetero-protein complexes with other UGE family members and with UDP-galactose transporters 2 (OsUGT2) and 3 (OsUGT3), which may facilitate the channeling of Gal to polysaccharides and proteoglycans.
33615714	8	37	dep	transporters	1061:1072	arg1	OsUGT2					1077:1082	OsUGT2	1077:1082	OsUGT2	1077:1082	We also show that BP1 can form homo- and hetero-protein complexes with other UGE family members and with UDP-galactose transporters 2 (OsUGT2) and 3 (OsUGT3), which may facilitate the channeling of Gal to polysaccharides and proteoglycans.
33615714	8	37	dep	transporters	1061:1072	arg1	3					1089:1089	3	1089:1089	3	1089:1089	We also show that BP1 can form homo- and hetero-protein complexes with other UGE family members and with UDP-galactose transporters 2 (OsUGT2) and 3 (OsUGT3), which may facilitate the channeling of Gal to polysaccharides and proteoglycans.
33615714	8	37	dep	transporters	1061:1072	arg1	2					1074:1074	2	1074:1074	2	1074:1074	We also show that BP1 can form homo- and hetero-protein complexes with other UGE family members and with UDP-galactose transporters 2 (OsUGT2) and 3 (OsUGT3), which may facilitate the channeling of Gal to polysaccharides and proteoglycans.
33615714	9	38	dep	composition	1252:1262	arg1	the					1242:1244	the	1242:1244	the	1242:1244	Our results demonstrate that BP1 participates in regulating the sugar composition and structure of rice cell walls.
33615714	6	39	contain	had	743:745	arg1	mutant					736:741	the mutant	732:741	the mutant	732:741	Moreover, the mutant had altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose.
33615714	6	39	contain	had	743:745	arg2	contents					755:762	altered contents	747:762	altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose	747:832	Moreover, the mutant had altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose.
33615714	0	40	theme	wall	43:46	arg1	composition					48:58	normal cell wall composition	31:58	normal cell wall composition	31:58	BRITTLE PLANT1 is required for normal cell wall composition and mechanical strength in rice.
33615714	5	41	contain	had	630:632	arg1	culms					624:628	The mutant culms	613:628	The mutant culms	613:628	The mutant culms had reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins.
33615714	5	41	contain	had	630:632	arg2	levels					642:647	reduced levels	634:647	reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins	634:719	The mutant culms had reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins.
33615714	5	42	theme	mutant	617:622	arg1	culms					624:628	The mutant culms	613:628	The mutant culms	613:628	The mutant culms had reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins.
33615714	0	43	from	composition	48:58	arg1	rice					87:90	rice	87:90	rice	87:90	BRITTLE PLANT1 is required for normal cell wall composition and mechanical strength in rice.
33615714	6	44	theme	cellulose	824:832	arg1	contents					755:762	altered contents	747:762	altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose	747:832	Moreover, the mutant had altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose.
33615714	0	45	theme	cell	38:41	arg1	composition					48:58	normal cell wall composition	31:58	normal cell wall composition	31:58	BRITTLE PLANT1 is required for normal cell wall composition and mechanical strength in rice.
33615714	8	46	theme	UDP-galactose	1047:1059	arg1	transporters					1061:1072	UDP-galactose transporters 2 (OsUGT2) and 3 (OsUGT3)	1047:1098	UDP-galactose transporters 2 (OsUGT2) and 3 (OsUGT3)	1047:1098	We also show that BP1 can form homo- and hetero-protein complexes with other UGE family members and with UDP-galactose transporters 2 (OsUGT2) and 3 (OsUGT3), which may facilitate the channeling of Gal to polysaccharides and proteoglycans.
33615714	6	47	theme	noncellulosic	789:801	arg1	monosaccharides					803:817	neutral noncellulosic monosaccharides	781:817	neutral noncellulosic monosaccharides	781:817	Moreover, the mutant had altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose.
33615714	1	48	theme	enzymes	138:144	arg1	series					95:100	A series	93:100	A series of nucleotide sugar interconversion enzymes (NSEs)	93:151	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	4	49	dep	brittle	566:572	arg1	leaves					574:579	leaves	574:579	leaves	574:579	Here, we report a brittle plant (bp1) rice mutant that exhibits brittle leaves and culms at all growth stages.
33615714	1	50	theme	nucleotide	105:114	arg1	enzymes					138:144	nucleotide sugar interconversion enzymes	105:144	nucleotide sugar interconversion enzymes (NSEs)	105:151	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	1	50	theme	nucleotide	105:114	arg1	NSEs					147:150	NSEs	147:150	NSEs	147:150	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	5	51	theme	reduced	634:640	arg1	levels					642:647	reduced levels	634:647	reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins	634:719	The mutant culms had reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins.
33615714	1	52	theme	sugar	116:120	arg1	enzymes					138:144	nucleotide sugar interconversion enzymes	105:144	nucleotide sugar interconversion enzymes (NSEs)	105:151	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	1	52	theme	sugar	116:120	arg1	NSEs					147:150	NSEs	147:150	NSEs	147:150	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	5	53	theme	arabinogalactan	696:710	arg1	proteins					712:719	arabinogalactan proteins	696:719	arabinogalactan proteins	696:719	The mutant culms had reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins.
33615714	6	54	theme	acids	774:778	arg1	contents					755:762	altered contents	747:762	altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose	747:832	Moreover, the mutant had altered contents of uronic acids, neutral noncellulosic monosaccharides, and cellulose.
33615714	3	55	from	roles	406:410	arg1	monocots					443:450	monocots	443:450	monocots	443:450	The roles of UDP-glucose 4-epimerases in monocots remain unclear due to redundancy in the pathways.
33615714	1	56	theme	interconversion	122:136	arg1	enzymes					138:144	nucleotide sugar interconversion enzymes	105:144	nucleotide sugar interconversion enzymes (NSEs)	105:151	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	1	56	theme	interconversion	122:136	arg1	NSEs					147:150	NSEs	147:150	NSEs	147:150	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	4	57	theme	growth	598:603	arg1	stages					605:610	all growth stages	594:610	all growth stages	594:610	Here, we report a brittle plant (bp1) rice mutant that exhibits brittle leaves and culms at all growth stages.
33615714	1	58	theme	cell	218:221	arg1	polysaccharides					235:249	cell wall matrix polysaccharides	218:249	cell wall matrix polysaccharides	218:249	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
33615714	5	59	theme	proteins	712:719	arg1	levels					642:647	reduced levels	634:647	reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins	634:719	The mutant culms had reduced levels of rhamnogalacturonan I, homogalacturonan, and arabinogalactan proteins.
33615714	2	60	theme	UDP-glucose	351:361	arg1	interconversion					332:346	the interconversion	328:346	the interconversion of UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal)	328:399	UDP-glucose 4-epimerases (UGEs) are NSEs that function in the interconversion of UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal).
33615714	1	61	theme	wall	223:226	arg1	polysaccharides					235:249	cell wall matrix polysaccharides	218:249	cell wall matrix polysaccharides	218:249	A series of nucleotide sugar interconversion enzymes (NSEs) generate the activated sugar donors required for biosynthesis of cell wall matrix polysaccharides and glycoproteins.
31967622	0	0	theme	infected	104:111	arg1	burns					113:117	chronic infected burns	96:117	chronic infected burns	96:117	Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
31967622	4	1	theme	hemocompatibility	748:764	arg1	studies					766:772	cytocompatibility and hemocompatibility studies	726:772	cytocompatibility and hemocompatibility studies	726:772	The hybrid scaffolds are shown to be appropriate for in vivo tissue regeneration through cytocompatibility and hemocompatibility studies.
31967622	5	2	theme	infected	847:854	arg1	wounds					861:866	chronically infected burn wounds	835:866	chronically infected burn wounds with respective controls	835:891	Scaffolds were applied to diabetic albino rats induced with chronically infected burn wounds with respective controls.
31967622	6	3	theme	hybrid	985:990	arg1	groups					1016:1021	the hybrid scaffold treated animal groups	981:1021	the hybrid scaffold treated animal groups	981:1021	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups showed improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing.
31967622	6	4	theme	wound	1130:1134	arg1	healing					1136:1142	scar-less wound healing	1120:1142	scar-less wound healing	1120:1142	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups showed improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing.
31967622	0	5	theme	chronic	96:102	arg1	burns					113:117	chronic infected burns	96:117	chronic infected burns	96:117	Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
31967622	6	6	theme	immunohistochemical	911:929	arg1	analyses					931:938	Histological and immunohistochemical analyses	894:938	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups	894:1021	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups showed improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing.
31967622	1	7	theme	diabetes	178:185	arg1	existence					165:173	The existence	161:173	The existence of diabetes and microbial infection in burn wounds	161:224	The existence of diabetes and microbial infection in burn wounds makes the healing process more complex.
31967622	6	8	theme	scar-less	1120:1128	arg1	healing					1136:1142	scar-less wound healing	1120:1142	scar-less wound healing	1120:1142	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups showed improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing.
31967622	5	9	theme	diabetic	801:808	arg1	rats					817:820	diabetic albino rats	801:820	diabetic albino rats induced with chronically infected burn wounds with respective controls	801:891	Scaffolds were applied to diabetic albino rats induced with chronically infected burn wounds with respective controls.
31967622	7	10	theme	scar-less	1236:1244	arg1	healing					1252:1258	effective scar-less wound healing	1226:1258	effective scar-less wound healing in chronic burn wounds	1226:1281	The results confirm that the prepared hybrid collagen scaffold could be used for effective scar-less wound healing in chronic burn wounds.
31967622	7	11	theme	chronic	1263:1269	arg1	wounds					1276:1281	chronic burn wounds	1263:1281	chronic burn wounds	1263:1281	The results confirm that the prepared hybrid collagen scaffold could be used for effective scar-less wound healing in chronic burn wounds.
31967622	2	12	theme	based	299:303	arg1	scaffold					312:319	a collagen based hybrid scaffold	288:319	a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection	288:525	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	0	13	theme	burns	113:117	arg1	healing					85:91	scar-less healing	75:91	scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats	75:158	Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
31967622	6	14	theme	animal	1009:1014	arg1	groups					1016:1021	the hybrid scaffold treated animal groups	981:1021	the hybrid scaffold treated animal groups	981:1021	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups showed improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing.
31967622	7	15	theme	wound	1246:1250	arg1	healing					1252:1258	effective scar-less wound healing	1226:1258	effective scar-less wound healing in chronic burn wounds	1226:1281	The results confirm that the prepared hybrid collagen scaffold could be used for effective scar-less wound healing in chronic burn wounds.
31967622	6	16	theme	Histological	894:905	arg1	analyses					931:938	Histological and immunohistochemical analyses	894:938	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups	894:1021	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups showed improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing.
31967622	2	17	theme	collagen	290:297	arg1	scaffold					312:319	a collagen based hybrid scaffold	288:319	a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection	288:525	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	4	18	theme	hybrid	641:646	arg1	appropriate					674:684	appropriate	674:684	appropriate	674:684	The hybrid scaffolds are shown to be appropriate for in vivo tissue regeneration through cytocompatibility and hemocompatibility studies.
31967622	4	18	theme	hybrid	641:646	arg1	scaffolds					648:656	The hybrid scaffolds	637:656	The hybrid scaffolds	637:656	The hybrid scaffolds are shown to be appropriate for in vivo tissue regeneration through cytocompatibility and hemocompatibility studies.
31967622	0	19	theme	diabetic	129:136	arg1	rats					155:158	type-I diabetic and non-diabetic rats	122:158	type-I diabetic and non-diabetic rats	122:158	Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
31967622	3	20	theme	spectroscopic	532:544	arg1	analyses					546:553	The spectroscopic analyses	528:553	The spectroscopic analyses of the hybrid scaffolds	528:577	The spectroscopic analyses of the hybrid scaffolds reveal the chemical and structural integrity of collagen.
31967622	1	21	from	existence	165:173	arg1	wounds					219:224	burn wounds	214:224	burn wounds	214:224	The existence of diabetes and microbial infection in burn wounds makes the healing process more complex.
31967622	5	22	with	wounds	861:866	arg1	controls					884:891	respective controls	873:891	respective controls	873:891	Scaffolds were applied to diabetic albino rats induced with chronically infected burn wounds with respective controls.
31967622	2	23	theme	seed	413:416	arg1	polysaccharide					418:431	an oxidized fenugreek seed polysaccharide	391:431	an oxidized fenugreek seed polysaccharide	391:431	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	0	24	theme	type-I	122:127	arg1	rats					155:158	type-I diabetic and non-diabetic rats	122:158	type-I diabetic and non-diabetic rats	122:158	Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
31967622	6	25	theme	scaffold	992:999	arg1	groups					1016:1021	the hybrid scaffold treated animal groups	981:1021	the hybrid scaffold treated animal groups	981:1021	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups showed improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing.
31967622	7	26	theme	effective	1226:1234	arg1	healing					1252:1258	effective scar-less wound healing	1226:1258	effective scar-less wound healing in chronic burn wounds	1226:1281	The results confirm that the prepared hybrid collagen scaffold could be used for effective scar-less wound healing in chronic burn wounds.
31967622	6	27	theme	tissue	959:964	arg1	analyses					931:938	Histological and immunohistochemical analyses	894:938	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups	894:1021	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups showed improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing.
31967622	1	28	theme	microbial	191:199	arg1	infection					201:209	microbial infection	191:209	microbial infection	191:209	The existence of diabetes and microbial infection in burn wounds makes the healing process more complex.
31967622	0	29	theme	microsphere-resorcinol	7:28	arg1	scaffolds					58:66	Silica microsphere-resorcinol composite embedded collagen scaffolds	0:66	Silica microsphere-resorcinol composite embedded collagen scaffolds	0:66	Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
31967622	5	30	theme	burn	856:859	arg1	wounds					861:866	chronically infected burn wounds	835:866	chronically infected burn wounds with respective controls	835:891	Scaffolds were applied to diabetic albino rats induced with chronically infected burn wounds with respective controls.
31967622	6	31	theme	treated	1001:1007	arg1	groups					1016:1021	the hybrid scaffold treated animal groups	981:1021	the hybrid scaffold treated animal groups	981:1021	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups showed improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing.
31967622	1	32	theme	infection	201:209	arg1	existence					165:173	The existence	161:173	The existence of diabetes and microbial infection in burn wounds	161:224	The existence of diabetes and microbial infection in burn wounds makes the healing process more complex.
31967622	0	33	theme	Silica	0:5	arg1	scaffolds					58:66	Silica microsphere-resorcinol composite embedded collagen scaffolds	0:66	Silica microsphere-resorcinol composite embedded collagen scaffolds	0:66	Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
31967622	3	34	theme	collagen	627:634	arg1	integrity					614:622	the chemical and structural integrity	586:622	the chemical and structural integrity of collagen	586:634	The spectroscopic analyses of the hybrid scaffolds reveal the chemical and structural integrity of collagen.
31967622	2	35	theme	fenugreek	403:411	arg1	polysaccharide					418:431	an oxidized fenugreek seed polysaccharide	391:431	an oxidized fenugreek seed polysaccharide	391:431	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	0	36	theme	embedded	40:47	arg1	scaffolds					58:66	Silica microsphere-resorcinol composite embedded collagen scaffolds	0:66	Silica microsphere-resorcinol composite embedded collagen scaffolds	0:66	Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
31967622	0	37	theme	non-diabetic	142:153	arg1	rats					155:158	type-I diabetic and non-diabetic rats	122:158	type-I diabetic and non-diabetic rats	122:158	Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
31967622	3	38	theme	structural	603:612	arg1	integrity					614:622	the chemical and structural integrity	586:622	the chemical and structural integrity of collagen	586:634	The spectroscopic analyses of the hybrid scaffolds reveal the chemical and structural integrity of collagen.
31967622	1	39	theme	burn	214:217	arg1	wounds					219:224	burn wounds	214:224	burn wounds	214:224	The existence of diabetes and microbial infection in burn wounds makes the healing process more complex.
31967622	0	40	theme	composite	30:38	arg1	scaffolds					58:66	Silica microsphere-resorcinol composite embedded collagen scaffolds	0:66	Silica microsphere-resorcinol composite embedded collagen scaffolds	0:66	Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
31967622	2	41	theme	hybrid	305:310	arg1	scaffold					312:319	a collagen based hybrid scaffold	288:319	a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection	288:525	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	6	42	theme	improved	1030:1037	arg1	angiogenesis					1039:1050	improved angiogenesis	1030:1050	improved angiogenesis	1030:1050	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups showed improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing.
31967622	3	43	theme	hybrid	562:567	arg1	scaffolds					569:577	the hybrid scaffolds	558:577	the hybrid scaffolds	558:577	The spectroscopic analyses of the hybrid scaffolds reveal the chemical and structural integrity of collagen.
31967622	4	44	theme	cytocompatibility	726:742	arg1	studies					766:772	cytocompatibility and hemocompatibility studies	726:772	cytocompatibility and hemocompatibility studies	726:772	The hybrid scaffolds are shown to be appropriate for in vivo tissue regeneration through cytocompatibility and hemocompatibility studies.
31967622	7	45	theme	hybrid	1183:1188	arg1	scaffold					1199:1206	the prepared hybrid collagen scaffold	1170:1206	the prepared hybrid collagen scaffold	1170:1206	The results confirm that the prepared hybrid collagen scaffold could be used for effective scar-less wound healing in chronic burn wounds.
31967622	2	46	theme	scar-less	446:454	arg1	healing					456:462	scar-less healing	446:462	scar-less healing	446:462	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	0	47	theme	collagen	49:56	arg1	scaffolds					58:66	Silica microsphere-resorcinol composite embedded collagen scaffolds	0:66	Silica microsphere-resorcinol composite embedded collagen scaffolds	0:66	Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
31967622	6	48	theme	TGF-β3	1077:1082	arg1	expression					1084:1093	TGF-β3 expression	1077:1093	TGF-β3 expression	1077:1093	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups showed improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing.
31967622	2	49	theme	microbial	507:515	arg1	infection					517:525	microbial infection	507:525	microbial infection	507:525	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	5	50	theme	albino	810:815	arg1	rats					817:820	diabetic albino rats	801:820	diabetic albino rats induced with chronically infected burn wounds with respective controls	801:891	Scaffolds were applied to diabetic albino rats induced with chronically infected burn wounds with respective controls.
31967622	4	51	dep	in	690:691	arg1	vivo					693:696	vivo	693:696	vivo	693:696	The hybrid scaffolds are shown to be appropriate for in vivo tissue regeneration through cytocompatibility and hemocompatibility studies.
31967622	2	52	with	wounds	475:480	arg1	diabetes					494:501	type-I diabetes	487:501	type-I diabetes	487:501	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	2	52	with	wounds	475:480	arg1	infection					517:525	microbial infection	507:525	microbial infection	507:525	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	4	53	theme	in	690:691	arg1	regeneration					705:716	in vivo tissue regeneration	690:716	in vivo tissue regeneration through cytocompatibility and hemocompatibility studies	690:772	The hybrid scaffolds are shown to be appropriate for in vivo tissue regeneration through cytocompatibility and hemocompatibility studies.
31967622	0	54	theme	scar-less	75:83	arg1	healing					85:91	scar-less healing	75:91	scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats	75:158	Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
31967622	7	55	used	used	1217:1220	arg2	scaffold					1199:1206	the prepared hybrid collagen scaffold	1170:1206	the prepared hybrid collagen scaffold	1170:1206	The results confirm that the prepared hybrid collagen scaffold could be used for effective scar-less wound healing in chronic burn wounds.
31967622	0	56	from	healing	85:91	arg1	rats					155:158	type-I diabetic and non-diabetic rats	122:158	type-I diabetic and non-diabetic rats	122:158	Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.
31967622	2	57	dep	scaffold	312:319	arg1	incorporated					321:332	incorporated	321:332	incorporated with a silica-resorcinol composite	321:367	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	2	57	dep	scaffold	312:319	arg1	cross-linked					373:384	cross-linked	373:384	cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection	373:525	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	7	58	theme	collagen	1190:1197	arg1	scaffold					1199:1206	the prepared hybrid collagen scaffold	1170:1206	the prepared hybrid collagen scaffold	1170:1206	The results confirm that the prepared hybrid collagen scaffold could be used for effective scar-less wound healing in chronic burn wounds.
31967622	7	59	from	healing	1252:1258	arg1	wounds					1276:1281	chronic burn wounds	1263:1281	chronic burn wounds	1263:1281	The results confirm that the prepared hybrid collagen scaffold could be used for effective scar-less wound healing in chronic burn wounds.
31967622	7	60	theme	prepared	1174:1181	arg1	scaffold					1199:1206	the prepared hybrid collagen scaffold	1170:1206	the prepared hybrid collagen scaffold	1170:1206	The results confirm that the prepared hybrid collagen scaffold could be used for effective scar-less wound healing in chronic burn wounds.
31967622	6	61	theme	granulation	947:957	arg1	tissue					959:964	the granulation tissue	943:964	the granulation tissue collected from the hybrid scaffold treated animal groups	943:1021	Histological and immunohistochemical analyses of the granulation tissue collected from the hybrid scaffold treated animal groups showed improved angiogenesis, reepithelialization and TGF-β3 expression, which eventually led to scar-less wound healing.
31967622	7	62	theme	burn	1271:1274	arg1	wounds					1276:1281	chronic burn wounds	1263:1281	chronic burn wounds	1263:1281	The results confirm that the prepared hybrid collagen scaffold could be used for effective scar-less wound healing in chronic burn wounds.
31967622	2	63	theme	silica-resorcinol	341:357	arg1	composite					359:367	a silica-resorcinol composite	339:367	a silica-resorcinol composite	339:367	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	1	64	theme	healing	236:242	arg1	process					244:250	the healing process	232:250	the healing process more complex	232:263	The existence of diabetes and microbial infection in burn wounds makes the healing process more complex.
31967622	3	65	theme	chemical	590:597	arg1	integrity					614:622	the chemical and structural integrity	586:622	the chemical and structural integrity of collagen	586:634	The spectroscopic analyses of the hybrid scaffolds reveal the chemical and structural integrity of collagen.
31967622	3	66	theme	scaffolds	569:577	arg1	analyses					546:553	The spectroscopic analyses	528:553	The spectroscopic analyses of the hybrid scaffolds	528:577	The spectroscopic analyses of the hybrid scaffolds reveal the chemical and structural integrity of collagen.
31967622	2	67	theme	oxidized	394:401	arg1	polysaccharide					418:431	an oxidized fenugreek seed polysaccharide	391:431	an oxidized fenugreek seed polysaccharide	391:431	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	4	68	theme	tissue	698:703	arg1	regeneration					705:716	in vivo tissue regeneration	690:716	in vivo tissue regeneration through cytocompatibility and hemocompatibility studies	690:772	The hybrid scaffolds are shown to be appropriate for in vivo tissue regeneration through cytocompatibility and hemocompatibility studies.
31967622	5	69	theme	respective	873:882	arg1	controls					884:891	respective controls	873:891	respective controls	873:891	Scaffolds were applied to diabetic albino rats induced with chronically infected burn wounds with respective controls.
31967622	2	70	theme	chronic	467:473	arg1	wounds					475:480	chronic wounds	467:480	chronic wounds with type-I diabetes and microbial infection	467:525	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	2	71	theme	type-I	487:492	arg1	diabetes					494:501	type-I diabetes	487:501	type-I diabetes	487:501	Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection.
31967622	1	72	theme	complex	257:263	arg1	process					244:250	the healing process	232:250	the healing process more complex	232:263	The existence of diabetes and microbial infection in burn wounds makes the healing process more complex.
34364617	4	0	theme	mechanical	689:698	arg1	morphology					655:664	The morphology	651:664	The morphology	651:664	The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC.
34364617	4	0	theme	mechanical	689:698	arg1	properties					712:721	mechanical and thermal properties	689:721	mechanical and thermal properties of the nanofibrous membranes	689:750	The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC.
34364617	6	1	from	improvement	923:933	arg1	cytobiocompatibility					1004:1023	cytobiocompatibility	1004:1023	cytobiocompatibility	1004:1023	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	6	1	from	improvement	923:933	arg1	properties					989:998	thermal, mechanical, antibacterial properties	954:998	thermal, mechanical, antibacterial properties	954:998	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	6	1	from	improvement	923:933	arg1	morphology					942:951	morphology	942:951	morphology	942:951	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	0	2	theme	electrospun	85:95	arg1	nanofibers					97:106	core-shell PVA/PCL electrospun nanofibers	66:106	core-shell PVA/PCL electrospun nanofibers	66:106	Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers.
34364617	7	3	theme	promising	1125:1133	arg1	scaffolds					1135:1143	promising scaffolds	1125:1143	promising scaffolds for tissue regeneration and wound healing	1125:1185	The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
34364617	3	4	theme	as-prepared	521:531	arg1	NPs					570:572	Ag-CS NPs	564:572	Ag-CS NPs	564:572	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	3	4	theme	as-prepared	521:531	arg1	nanoparticles					549:561	as-prepared silver-chitosan nanoparticles	521:561	as-prepared silver-chitosan nanoparticles (Ag-CS NPs)	521:573	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	6	5	theme	antibacterial	975:987	arg1	properties					989:998	thermal, mechanical, antibacterial properties	954:998	thermal, mechanical, antibacterial properties	954:998	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	7	6	theme	Ag-CS	1235:1239	arg1	NPs					1241:1243	phenytoin and Ag-CS NPs	1221:1243	phenytoin and Ag-CS NPs	1221:1243	The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
34364617	7	7	theme	proposed	1083:1090	arg1	NFs					1111:1113	The proposed core-shell PVA/PCL NFs	1079:1113	The proposed core-shell PVA/PCL NFs	1079:1113	The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
34364617	7	8	theme	PVA/PCL	1103:1109	arg1	NFs					1111:1113	The proposed core-shell PVA/PCL NFs	1079:1113	The proposed core-shell PVA/PCL NFs	1079:1113	The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
34364617	4	9	theme	membranes	742:750	arg1	morphology					655:664	The morphology	651:664	The morphology	651:664	The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC.
34364617	4	9	theme	membranes	742:750	arg1	properties					712:721	mechanical and thermal properties	689:721	mechanical and thermal properties of the nanofibrous membranes	689:750	The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC.
34364617	4	10	theme	nanofibrous	730:740	arg1	membranes					742:750	the nanofibrous membranes	726:750	the nanofibrous membranes	726:750	The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC.
34364617	7	11	theme	NPs	1241:1243	arg1	delivery					1209:1216	the effective dual delivery	1190:1216	the effective dual delivery of phenytoin and Ag-CS NPs	1190:1243	The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
34364617	1	12	theme	coaxial	161:167	arg1	techniques					169:178	coaxial techniques	161:178	coaxial techniques	161:178	Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work.
34364617	7	13	theme	wound	1173:1177	arg1	healing					1179:1185	wound healing	1173:1185	wound healing	1173:1185	The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
34364617	2	14	theme	nanofibrous	299:309	arg1	membranes					311:319	core-shell electrospun nanofibrous membranes	276:319	core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity	276:389	This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity.
34364617	6	15	theme	NPs	1074:1076	arg1	incorporation					1044:1056	incorporation	1044:1056	incorporation of Ph and Ag-CS NPs	1044:1076	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	3	16	theme	well-known	428:437	arg1	phenytoin					410:418	phenytoin	410:418	phenytoin (Ph)	410:423	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	3	16	theme	well-known	428:437	arg1	agent					453:457	a well-known proliferative agent	426:457	a well-known proliferative agent	426:457	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	5	17	theme	PVA/PCL-Ph	889:898	arg1	NFs					900:902	PVA/PCL-Ph NFs	889:902	PVA/PCL-Ph NFs	889:902	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs.
34364617	7	18	theme	tissue	1149:1154	arg1	regeneration					1156:1167	tissue regeneration	1149:1167	tissue regeneration	1149:1167	The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
34364617	2	19	theme	electrospun	287:297	arg1	membranes					311:319	core-shell electrospun nanofibrous membranes	276:319	core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity	276:389	This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity.
34364617	6	20	theme	Ag-CS	1068:1072	arg1	NPs					1074:1076	Ph and Ag-CS NPs	1061:1076	Ph and Ag-CS NPs	1061:1076	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	7	21	theme	phenytoin	1221:1229	arg1	NPs					1241:1243	phenytoin and Ag-CS NPs	1221:1243	phenytoin and Ag-CS NPs	1221:1243	The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
34364617	3	22	theme	biocidal	579:586	arg1	agents					588:593	biocidal agents	579:593	biocidal agents	579:593	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	0	23	theme	Dual-drug	0:8	arg1	delivery					10:17	Dual-drug delivery	0:17	Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers.	0:107	Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers.
34364617	6	24	dep	thermal	954:960	arg1	mechanical					963:972	mechanical	963:972	mechanical	963:972	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	1	25	theme	Dual-drug	109:117	arg1	systems					128:134	Dual-drug delivery systems	109:134	Dual-drug delivery systems	109:134	Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work.
34364617	1	26	theme	model	211:215	arg1	drugs					217:221	the model drugs	207:221	the model drugs used the present work	207:243	Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work.
34364617	0	27	theme	Ag-chitosan	22:32	arg1	nanoparticles					34:46	Ag-chitosan nanoparticles	22:46	Ag-chitosan nanoparticles	22:46	Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers.
34364617	5	28	theme	coaxial	804:810	arg1	NFs					845:847	NFs	845:847	NFs	845:847	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs.
34364617	5	28	theme	coaxial	804:810	arg1	nanofibers					833:842	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers	800:842	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs)	800:848	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs.
34364617	2	29	theme	cell	345:348	arg1	proliferation					350:362	simultaneous cell proliferation	332:362	simultaneous cell proliferation	332:362	This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity.
34364617	7	30	theme	core-shell	1092:1101	arg1	NFs					1111:1113	The proposed core-shell PVA/PCL NFs	1079:1113	The proposed core-shell PVA/PCL NFs	1079:1113	The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
34364617	5	31	theme	NPs/PCL-Ph	822:831	arg1	NFs					845:847	NFs	845:847	NFs	845:847	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs.
34364617	5	31	theme	NPs/PCL-Ph	822:831	arg1	nanofibers					833:842	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers	800:842	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs)	800:848	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs.
34364617	5	32	theme	CS	819:820	arg1	NFs					845:847	NFs	845:847	NFs	845:847	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs.
34364617	5	32	theme	CS	819:820	arg1	nanofibers					833:842	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers	800:842	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs)	800:848	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs.
34364617	3	33	theme	core	639:642	arg1	layer					644:648	a polyvinyl alcohol (PVA) core layer	613:648	a polyvinyl alcohol (PVA) core layer	613:648	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	2	34	theme	simultaneous	332:343	arg1	proliferation					350:362	simultaneous cell proliferation	332:362	simultaneous cell proliferation	332:362	This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity.
34364617	3	35	from	embedded	601:608	arg1	layer					644:648	a polyvinyl alcohol (PVA) core layer	613:648	a polyvinyl alcohol (PVA) core layer	613:648	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	5	36	theme	Ph	873:874	arg1	release					876:882	more controlled Ph release	857:882	more controlled Ph release	857:882	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs.
34364617	3	37	theme	proliferative	439:451	arg1	phenytoin					410:418	phenytoin	410:418	phenytoin (Ph)	410:423	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	3	37	theme	proliferative	439:451	arg1	agent					453:457	a well-known proliferative agent	426:457	a well-known proliferative agent	426:457	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	5	38	theme	controlled	862:871	arg1	release					876:882	more controlled Ph release	857:882	more controlled Ph release	857:882	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs.
34364617	0	39	theme	nanoparticles	34:46	arg1	delivery					10:17	Dual-drug delivery	0:17	Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers.	0:107	Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers.
34364617	5	40	theme	PVA-Ag	812:817	arg1	NFs					845:847	NFs	845:847	NFs	845:847	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs.
34364617	5	40	theme	PVA-Ag	812:817	arg1	nanofibers					833:842	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers	800:842	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs)	800:848	The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs.
34364617	1	41	theme	present	232:238	arg1	work					240:243	the present work	228:243	the present work	228:243	Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work.
34364617	7	42	theme	dual	1204:1207	arg1	delivery					1209:1216	the effective dual delivery	1190:1216	the effective dual delivery of phenytoin and Ag-CS NPs	1190:1243	The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
34364617	6	43	theme	fibers	1032:1037	arg1	cytobiocompatibility					1004:1023	cytobiocompatibility	1004:1023	cytobiocompatibility	1004:1023	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	6	43	theme	fibers	1032:1037	arg1	properties					989:998	thermal, mechanical, antibacterial properties	954:998	thermal, mechanical, antibacterial properties	954:998	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	6	43	theme	fibers	1032:1037	arg1	morphology					942:951	morphology	942:951	morphology	942:951	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	6	44	theme	thermal	954:960	arg1	properties					989:998	thermal, mechanical, antibacterial properties	954:998	thermal, mechanical, antibacterial properties	954:998	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	4	45	theme	thermal	704:710	arg1	morphology					655:664	The morphology	651:664	The morphology	651:664	The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC.
34364617	4	45	theme	thermal	704:710	arg1	properties					712:721	mechanical and thermal properties	689:721	mechanical and thermal properties of the nanofibrous membranes	689:750	The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC.
34364617	0	46	theme	phenytoin	52:60	arg1	delivery					10:17	Dual-drug delivery	0:17	Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers.	0:107	Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers.
34364617	7	47	theme	effective	1194:1202	arg1	delivery					1209:1216	the effective dual delivery	1190:1216	the effective dual delivery of phenytoin and Ag-CS NPs	1190:1243	The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
34364617	6	48	dep	morphology	942:951	arg1	the					938:940	the	938:940	the	938:940	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	3	49	from	layer	644:648	arg1	embedded					601:608	embedded	601:608	embedded	601:608	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	6	50	theme	notable	915:921	arg1	improvement					923:933	notable improvement	915:933	notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs	915:1076	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	2	51	theme	core-shell	276:285	arg1	membranes					311:319	core-shell electrospun nanofibrous membranes	276:319	core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity	276:389	This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity.
34364617	3	52	theme	alcohol	625:631	arg1	layer					644:648	a polyvinyl alcohol (PVA) core layer	613:648	a polyvinyl alcohol (PVA) core layer	613:648	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	1	53	theme	delivery	119:126	arg1	systems					128:134	Dual-drug delivery systems	109:134	Dual-drug delivery systems	109:134	Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work.
34364617	3	54	theme	Ag-CS	564:568	arg1	NPs					570:572	Ag-CS NPs	564:572	Ag-CS NPs	564:572	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	3	54	theme	Ag-CS	564:568	arg1	nanoparticles					549:561	as-prepared silver-chitosan nanoparticles	521:561	as-prepared silver-chitosan nanoparticles (Ag-CS NPs)	521:573	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	6	55	theme	Ph	1061:1062	arg1	NPs					1074:1076	Ph and Ag-CS NPs	1061:1076	Ph and Ag-CS NPs	1061:1076	There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs.
34364617	2	56	theme	antibacterial	368:380	arg1	activity					382:389	antibacterial activity	368:389	antibacterial activity	368:389	This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity.
34364617	0	57	theme	PVA/PCL	77:83	arg1	nanofibers					97:106	core-shell PVA/PCL electrospun nanofibers	66:106	core-shell PVA/PCL electrospun nanofibers	66:106	Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers.
34364617	3	58	theme	polycaprolactone	478:493	arg1	membrane					507:514	a polycaprolactone (PCL) shell membrane	476:514	a polycaprolactone (PCL) shell membrane	476:514	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	3	58	theme	polycaprolactone	478:493	arg1	PCL					496:498	PCL	496:498	PCL	496:498	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	3	59	theme	silver-chitosan	533:547	arg1	NPs					570:572	Ag-CS NPs	564:572	Ag-CS NPs	564:572	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	3	59	theme	silver-chitosan	533:547	arg1	nanoparticles					549:561	as-prepared silver-chitosan nanoparticles	521:561	as-prepared silver-chitosan nanoparticles (Ag-CS NPs)	521:573	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	3	60	theme	shell	501:505	arg1	membrane					507:514	a polycaprolactone (PCL) shell membrane	476:514	a polycaprolactone (PCL) shell membrane	476:514	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	3	60	theme	shell	501:505	arg1	PCL					496:498	PCL	496:498	PCL	496:498	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	0	61	theme	core-shell	66:75	arg1	nanofibers					97:106	core-shell PVA/PCL electrospun nanofibers	66:106	core-shell PVA/PCL electrospun nanofibers	66:106	Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers.
34364617	3	62	theme	polyvinyl	615:623	arg1	PVA					634:636	PVA	634:636	PVA	634:636	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	3	62	theme	polyvinyl	615:623	arg1	alcohol					625:631	a polyvinyl alcohol	613:631	a polyvinyl alcohol (PVA) core layer	613:648	For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer.
34364617	4	63	theme	chemical	667:674	arg1	morphology					655:664	The morphology	651:664	The morphology	651:664	The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC.
34364617	4	63	theme	chemical	667:674	arg1	composition					676:686	chemical composition	667:686	chemical composition	667:686	The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC.
34688682	3	0	theme	Chondroitin	327:337	arg1	sulphate					339:346	Chondroitin sulphate	327:346	Chondroitin sulphate	327:346	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	4	1	theme	marked	507:512	arg1	effect					530:535	a marked anti-adipogenic effect	505:535	a marked anti-adipogenic effect	505:535	Further, bmGAGs exhibited a marked anti-adipogenic effect in 3 T3-L1 cells without affecting cell viability at the concentration used.
34688682	0	2	theme	anti-adipogenic	82:96	arg1	activity					98:105	their anti-adipogenic activity	76:105	their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α	76:139	Composition and structure elucidation of bovine milk glycosaminoglycans and their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α.
34688682	6	3	theme	significant	879:889	arg1	decrease					891:898	significant decrease	879:898	significant decrease in both gene and protein levels	879:930	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	7	4	theme	Sterol	933:938	arg1	protein					967:973	Sterol regulatory element-binding protein 1c	933:976	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ	933:1067	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ was inversely affected by bmGAGs and the fatty acid synthase (FAS) expression was modulated.
34688682	7	4	theme	Sterol	933:938	arg1	SREBP-1c					979:986	SREBP-1c	979:986	SREBP-1c	979:986	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ was inversely affected by bmGAGs and the fatty acid synthase (FAS) expression was modulated.
34688682	1	5	theme	Glycosaminoglycans	177:194	arg1	relation					165:172	The structure function relation	142:172	The structure function relation of Glycosaminoglycans from bovine milk (bmGAGs)	142:220	The structure function relation of Glycosaminoglycans from bovine milk (bmGAGs) has not been studied in detail.
34688682	3	6	theme	major	363:367	arg1	GAGs					369:372	the major GAGs	359:372	the major GAGs	359:372	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	3	7	dep	had	386:388	arg1	4S					423:424	4S	423:424	4S	423:424	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	3	7	dep	had	386:388	arg1	-GalNAc					415:421	GlcA(2S)-GalNAc	407:421	GlcA(2S)-GalNAc(4S)	407:425	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	7	8	theme	regulatory	940:949	arg1	protein					967:973	Sterol regulatory element-binding protein 1c	933:976	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ	933:1067	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ was inversely affected by bmGAGs and the fatty acid synthase (FAS) expression was modulated.
34688682	7	8	theme	regulatory	940:949	arg1	SREBP-1c					979:986	SREBP-1c	979:986	SREBP-1c	979:986	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ was inversely affected by bmGAGs and the fatty acid synthase (FAS) expression was modulated.
34688682	3	9	theme	GAGs	369:372	arg1	one					352:354	one	352:354	one	352:354	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	3	9	theme	GAGs	369:372	arg1	GAGs					369:372	the major GAGs	359:372	the major GAGs	359:372	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	6	10	from	decrease	891:898	arg1	levels					925:930	both gene and protein levels	903:930	levels	925:930	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	4	11	theme	anti-adipogenic	514:528	arg1	effect					530:535	a marked anti-adipogenic effect	505:535	a marked anti-adipogenic effect	505:535	Further, bmGAGs exhibited a marked anti-adipogenic effect in 3 T3-L1 cells without affecting cell viability at the concentration used.
34688682	1	12	from	relation	165:172	arg1	milk					208:211	bovine milk	201:211	bovine milk (bmGAGs)	201:220	The structure function relation of Glycosaminoglycans from bovine milk (bmGAGs) has not been studied in detail.
34688682	1	12	from	relation	165:172	arg1	bmGAGs					214:219	bmGAGs	214:219	bmGAGs	214:219	The structure function relation of Glycosaminoglycans from bovine milk (bmGAGs) has not been studied in detail.
34688682	3	13	theme	2S	412:413	arg1	4S					423:424	4S	423:424	4S	423:424	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	3	13	theme	2S	412:413	arg1	-GalNAc					415:421	GlcA(2S)-GalNAc	407:421	GlcA(2S)-GalNAc(4S)	407:425	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	0	14	theme	PPAR-γ	122:127	arg1	activity					98:105	their anti-adipogenic activity	76:105	their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α	76:139	Composition and structure elucidation of bovine milk glycosaminoglycans and their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α.
34688682	3	15	theme	ΔDi-diSB	397:404	arg1	ΔDi-diSB					397:404	ΔDi-diSB	397:404	ΔDi-diSB	397:404	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	3	15	theme	ΔDi-diSB	397:404	arg1	%					392:392	65%	390:392	65% of ΔDi-diSB	390:404	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	6	16	theme	receptor	756:763	arg1	PPAR-γ					768:773	PPAR-γ	768:773	PPAR-γ	768:773	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	6	16	theme	receptor	756:763	arg1	γ					765:765	Peroxisome proliferator activated receptor γ	722:765	Peroxisome proliferator activated receptor γ (PPAR-γ)	722:774	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	1	17	theme	bovine	201:206	arg1	milk					208:211	bovine milk	201:211	bovine milk (bmGAGs)	201:220	The structure function relation of Glycosaminoglycans from bovine milk (bmGAGs) has not been studied in detail.
34688682	1	17	theme	bovine	201:206	arg1	bmGAGs					214:219	bmGAGs	214:219	bmGAGs	214:219	The structure function relation of Glycosaminoglycans from bovine milk (bmGAGs) has not been studied in detail.
34688682	6	18	theme	transcription	834:846	arg1	factors					848:854	the critical transcription factors	821:854	the critical transcription factors in adipogenesis	821:870	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	7	19	theme	PPAR-γ	1062:1067	arg1	activity					1050:1057	the activity	1046:1057	the activity of PPAR-γ	1046:1067	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ was inversely affected by bmGAGs and the fatty acid synthase (FAS) expression was modulated.
34688682	6	20	theme	activated	746:754	arg1	PPAR-γ					768:773	PPAR-γ	768:773	PPAR-γ	768:773	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	6	20	theme	activated	746:754	arg1	γ					765:765	Peroxisome proliferator activated receptor γ	722:765	Peroxisome proliferator activated receptor γ (PPAR-γ)	722:774	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	8	21	from	supplement/therapeutic	1347:1368	arg1	management					1377:1386	the management	1373:1386	the management of obesity	1373:1397	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	3	22	theme	GlcA	407:410	arg1	4S					423:424	4S	423:424	4S	423:424	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	3	22	theme	GlcA	407:410	arg1	-GalNAc					415:421	GlcA(2S)-GalNAc	407:421	GlcA(2S)-GalNAc(4S)	407:425	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	7	23	theme	synthase	1121:1128	arg1	expression					1136:1145	the fatty acid synthase (FAS) expression	1106:1145	the fatty acid synthase (FAS) expression	1106:1145	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ was inversely affected by bmGAGs and the fatty acid synthase (FAS) expression was modulated.
34688682	6	24	theme	proliferator	733:744	arg1	PPAR-γ					768:773	PPAR-γ	768:773	PPAR-γ	768:773	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	6	24	theme	proliferator	733:744	arg1	γ					765:765	Peroxisome proliferator activated receptor γ	722:765	Peroxisome proliferator activated receptor γ (PPAR-γ)	722:774	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	3	25	contain	had	386:388	arg2	ΔDi-diSB					397:404	ΔDi-diSB	397:404	ΔDi-diSB	397:404	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	3	25	contain	had	386:388	arg1	sulphate					339:346	Chondroitin sulphate	327:346	Chondroitin sulphate	327:346	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	3	25	contain	had	386:388	arg2	%					392:392	65%	390:392	65% of ΔDi-diSB	390:404	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	8	26	theme	present	1172:1178	arg1	work					1180:1183	the present work	1168:1183	the present work	1168:1183	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	6	27	dep	γ	765:765	arg1	factors					848:854	the critical transcription factors	821:854	the critical transcription factors in adipogenesis	821:870	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	4	28	theme	cell	572:575	arg1	viability					577:585	cell viability	572:585	cell viability	572:585	Further, bmGAGs exhibited a marked anti-adipogenic effect in 3 T3-L1 cells without affecting cell viability at the concentration used.
34688682	0	29	theme	C/EBP-α	133:139	arg1	activity					98:105	their anti-adipogenic activity	76:105	their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α	76:139	Composition and structure elucidation of bovine milk glycosaminoglycans and their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α.
34688682	6	30	theme	critical	825:832	arg1	factors					848:854	the critical transcription factors	821:854	the critical transcription factors in adipogenesis	821:870	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	8	31	theme	marker	1297:1302	arg1	bmGAGs					1323:1328	bmGAGs	1323:1328	the adipogenesis-related marker proteins and hence bmGAGs	1272:1328	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	8	31	theme	marker	1297:1302	arg1	supplement/therapeutic					1347:1368	a supplement/therapeutic	1345:1368	a supplement/therapeutic in the management of obesity	1345:1397	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	8	31	theme	marker	1297:1302	arg1	proteins					1304:1311	the adipogenesis-related marker proteins	1272:1311	the adipogenesis-related marker proteins and hence bmGAGs	1272:1328	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	8	32	theme	adipogenesis-related	1276:1295	arg1	bmGAGs					1323:1328	bmGAGs	1323:1328	the adipogenesis-related marker proteins and hence bmGAGs	1272:1328	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	8	32	theme	adipogenesis-related	1276:1295	arg1	supplement/therapeutic					1347:1368	a supplement/therapeutic	1345:1368	a supplement/therapeutic in the management of obesity	1345:1397	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	8	32	theme	adipogenesis-related	1276:1295	arg1	proteins					1304:1311	the adipogenesis-related marker proteins	1272:1311	the adipogenesis-related marker proteins and hence bmGAGs	1272:1328	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	0	33	theme	bovine	41:46	arg1	glycosaminoglycans					53:70	bovine milk glycosaminoglycans	41:70	bovine milk glycosaminoglycans	41:70	Composition and structure elucidation of bovine milk glycosaminoglycans and their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α.
34688682	7	34	theme	fatty	1110:1114	arg1	synthase					1121:1128	fatty acid synthase	1110:1128	the fatty acid synthase (FAS) expression	1106:1145	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ was inversely affected by bmGAGs and the fatty acid synthase (FAS) expression was modulated.
34688682	7	34	theme	fatty	1110:1114	arg1	FAS					1131:1133	FAS	1131:1133	FAS	1131:1133	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ was inversely affected by bmGAGs and the fatty acid synthase (FAS) expression was modulated.
34688682	6	35	theme	protein	917:923	arg1	levels					925:930	both gene and protein levels	903:930	levels	925:930	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	8	36	used	used	1337:1340	arg2	proteins					1304:1311	the adipogenesis-related marker proteins	1272:1311	the adipogenesis-related marker proteins and hence bmGAGs	1272:1328	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	8	36	used	used	1337:1340	arg2	supplement/therapeutic					1347:1368	a supplement/therapeutic	1345:1368	a supplement/therapeutic in the management of obesity	1345:1397	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	8	36	used	used	1337:1340	arg2	bmGAGs					1323:1328	bmGAGs	1323:1328	the adipogenesis-related marker proteins and hence bmGAGs	1272:1328	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	0	37	theme	glycosaminoglycans	53:70	arg1	structure					16:24	structure	16:24	structure	16:24	Composition and structure elucidation of bovine milk glycosaminoglycans and their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α.
34688682	0	37	theme	glycosaminoglycans	53:70	arg1	Composition					0:10	Composition	0:10	Composition	0:10	Composition and structure elucidation of bovine milk glycosaminoglycans and their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α.
34688682	0	37	theme	glycosaminoglycans	53:70	arg1	activity					98:105	their anti-adipogenic activity	76:105	their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α	76:139	Composition and structure elucidation of bovine milk glycosaminoglycans and their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α.
34688682	6	38	from	factors	848:854	arg1	adipogenesis					859:870	adipogenesis	859:870	adipogenesis	859:870	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	8	39	theme	bmGAGs	1251:1256	arg1	activity					1239:1246	an anti-adipogenic activity	1220:1246	an anti-adipogenic activity of bmGAGs	1220:1256	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	0	40	theme	milk	48:51	arg1	glycosaminoglycans					53:70	bovine milk glycosaminoglycans	41:70	bovine milk glycosaminoglycans	41:70	Composition and structure elucidation of bovine milk glycosaminoglycans and their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α.
34688682	6	41	theme	gene	908:911	arg1	levels					925:930	both gene and protein levels	903:930	levels	925:930	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	5	42	theme	triglyceride	618:629	arg1	content					631:637	The triglyceride content	614:637	The triglyceride content treated with bmGAGs	614:657	The triglyceride content treated with bmGAGs was significantly decreased as assessed by Oil-Red O staining.
34688682	6	43	theme	Peroxisome	722:731	arg1	proliferator					733:744	Peroxisome proliferator	722:744	Peroxisome proliferator activated receptor γ (PPAR-γ)	722:774	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	7	44	theme	acid	1116:1119	arg1	synthase					1121:1128	fatty acid synthase	1110:1128	the fatty acid synthase (FAS) expression	1106:1145	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ was inversely affected by bmGAGs and the fatty acid synthase (FAS) expression was modulated.
34688682	7	44	theme	acid	1116:1119	arg1	FAS					1131:1133	FAS	1131:1133	FAS	1131:1133	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ was inversely affected by bmGAGs and the fatty acid synthase (FAS) expression was modulated.
34688682	8	45	theme	obesity	1391:1397	arg1	management					1377:1386	the management	1373:1386	the management of obesity	1373:1397	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	2	46	theme	present	261:267	arg1	study					269:273	the present study	257:273	the present study	257:273	In the present study bmGAGs was isolated and structurally characterized.
34688682	4	47	theme	3 T3-L1	540:546	arg1	cells					548:552	3 T3-L1 cells	540:552	3 T3-L1 cells	540:552	Further, bmGAGs exhibited a marked anti-adipogenic effect in 3 T3-L1 cells without affecting cell viability at the concentration used.
34688682	7	48	theme	adipocyte	1007:1015	arg1	differentiation					1017:1031	the adipocyte differentiation	1003:1031	the adipocyte differentiation	1003:1031	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ was inversely affected by bmGAGs and the fatty acid synthase (FAS) expression was modulated.
34688682	6	49	theme	CCAAT/enhancer-binding	780:801	arg1	proteins					803:810	CCAAT/enhancer-binding proteins	780:810	CCAAT/enhancer-binding proteins (C/EBPα)	780:819	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	6	49	theme	CCAAT/enhancer-binding	780:801	arg1	C/EBPα					813:818	C/EBPα	813:818	C/EBPα	813:818	Peroxisome proliferator activated receptor γ (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPα) the critical transcription factors in adipogenesis showed significant decrease in both gene and protein levels.
34688682	1	50	from	milk	208:211	arg1	relation					165:172	The structure function relation	142:172	The structure function relation of Glycosaminoglycans from bovine milk (bmGAGs)	142:220	The structure function relation of Glycosaminoglycans from bovine milk (bmGAGs) has not been studied in detail.
34688682	1	50	from	milk	208:211	arg1	Glycosaminoglycans					177:194	Glycosaminoglycans	177:194	Glycosaminoglycans from bovine milk (bmGAGs)	177:220	The structure function relation of Glycosaminoglycans from bovine milk (bmGAGs) has not been studied in detail.
34688682	1	51	theme	structure	146:154	arg1	relation					165:172	The structure function relation	142:172	The structure function relation of Glycosaminoglycans from bovine milk (bmGAGs)	142:220	The structure function relation of Glycosaminoglycans from bovine milk (bmGAGs) has not been studied in detail.
34688682	5	52	theme	Oil-Red	702:708	arg1	staining					712:719	Oil-Red O staining	702:719	Oil-Red O staining	702:719	The triglyceride content treated with bmGAGs was significantly decreased as assessed by Oil-Red O staining.
34688682	8	53	theme	anti-adipogenic	1223:1237	arg1	activity					1239:1246	an anti-adipogenic activity	1220:1246	an anti-adipogenic activity of bmGAGs	1220:1256	Thus, the present work is among the firsts to demonstrate an anti-adipogenic activity of bmGAGs by modulating the adipogenesis-related marker proteins and hence bmGAGs may be used as a supplement/therapeutic in the management of obesity.
34688682	1	54	theme	function	156:163	arg1	relation					165:172	The structure function relation	142:172	The structure function relation of Glycosaminoglycans from bovine milk (bmGAGs)	142:220	The structure function relation of Glycosaminoglycans from bovine milk (bmGAGs) has not been studied in detail.
34688682	5	55	theme	O	710:710	arg1	staining					712:719	Oil-Red O staining	702:719	Oil-Red O staining	702:719	The triglyceride content treated with bmGAGs was significantly decreased as assessed by Oil-Red O staining.
34688682	0	56	dep	Composition	0:10	arg1	elucidation					26:36	elucidation	26:36	elucidation	26:36	Composition and structure elucidation of bovine milk glycosaminoglycans and their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α.
34688682	7	57	theme	element-binding	951:965	arg1	protein					967:973	Sterol regulatory element-binding protein 1c	933:976	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ	933:1067	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ was inversely affected by bmGAGs and the fatty acid synthase (FAS) expression was modulated.
34688682	7	57	theme	element-binding	951:965	arg1	SREBP-1c					979:986	SREBP-1c	979:986	SREBP-1c	979:986	Sterol regulatory element-binding protein 1c (SREBP-1c) that promotes the adipocyte differentiation by enhancing the activity of PPAR-γ was inversely affected by bmGAGs and the fatty acid synthase (FAS) expression was modulated.
34688682	3	58	theme	ΔDi-4S	448:453	arg1	%					443:443	18%	441:443	18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc)	441:476	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	3	58	theme	ΔDi-4S	448:453	arg1	Δ4,5HexUAα1 → 3GalNAc					455:475	Δ4,5HexUAα1 → 3GalNAc	455:475	Δ4,5HexUAα1 → 3GalNAc	455:475	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
34688682	3	58	theme	ΔDi-4S	448:453	arg1	ΔDi-4S					448:453	ΔDi-4S	448:453	ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc)	448:476	Chondroitin sulphate was one of the major GAGs present and had 65% of ΔDi-diSB (GlcA(2S)-GalNAc(4S)), followed by 18% of ΔDi-4S(Δ4,5HexUAα1 → 3GalNAc).
32793939	2	0	theme	mono	320:323	arg1	mixture					309:315	commercial mixture	298:315	commercial mixture of mono and di-glycerides (E471)	298:348	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	2	0	theme	mono	320:323	arg1	cellulose					261:269	ethyl cellulose	255:269	ethyl cellulose (EC) (20 cP and 45 cP)	255:292	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	2	0	theme	mono	320:323	arg1	EC					272:273	EC	272:273	EC	272:273	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	8	1	from	lipolysis	1220:1228	arg1	order					1237:1241	the order	1233:1241	the order of EC < E471 	1233:1255	Maximum lipolysis in the order of EC < E471 : EC < E471 was obtained, implying an effect of the structuring agent used on the lipolysis profile.
32793939	4	2	theme	combined	548:555	arg1	system					557:562	the combined system	544:562	the combined system	544:562	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	3	3	theme	intestinal	498:507	arg1	lipolysis					509:517	intestinal lipolysis	498:517	intestinal lipolysis	498:517	The results suggest that the combination of E471 and EC significantly affects both gel physical properties and intestinal lipolysis.
32793939	12	4	theme	Such	1784:1787	arg1	design					1798:1803	Such rational design	1784:1803	Such rational design	1784:1803	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	12	5	theme	mimetic	1846:1852	arg1	systems					1854:1860	new fat mimetic systems	1838:1860	new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase	1838:1975	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	9	6	theme	E471 	1479:1483	arg1	order					1463:1467	the order	1459:1467	the order of E471 < E471 : EC < EC	1459:1492	A first-order kinetics analysis fitted to the lipolysis profiles demonstrated rate constant values in the order of E471 < E471 : EC < EC.
32793939	6	7	theme	synergistic	1064:1074	arg1	effect					1076:1081	a synergistic effect	1062:1081	a synergistic effect	1062:1081	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	2	8	dep	cellulose	261:269	arg1	cP					280:281	20 cP	277:281	20 cP	277:281	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	2	8	dep	cellulose	261:269	arg1	cP					290:291	45 cP	287:291	45 cP	287:291	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	10	9	theme	oil	1531:1533	arg1	state					1535:1539	the oil state	1527:1539	the oil state	1527:1539	Such behavior was attributed to the oil state, liquid vs. solid, and the network strength, both of which limit the lipase activity by hindering liquid TAG accessibility.
32793939	1	10	theme	oleogels	177:184	arg1	hydrolysis					163:172	lipid hydrolysis	157:172	lipid hydrolysis of oleogels using a combination of different structuring agents	157:236	This research demonstrates the ability to direct the rate and extent of lipid hydrolysis of oleogels using a combination of different structuring agents.
32793939	9	11	theme	 EC	1485:1487	arg1	EC					1491:1492	 EC < EC	1485:1492	E471 < E471 : EC < EC	1472:1492	A first-order kinetics analysis fitted to the lipolysis profiles demonstrated rate constant values in the order of E471 < E471 : EC < EC.
32793939	6	12	theme	contribution	1037:1048	arg1	addition					1010:1017	the simple addition	999:1017	the simple addition of each component contribution	999:1048	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	6	13	theme	E471 	1115:1119	arg1	ratio					1131:1135	7 : 3 E471 : EC 20 cP ratio	1109:1135	7 : 3 E471 : EC 20 cP ratio	1109:1135	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	12	14	theme	lipid	1887:1891	arg1	profile					1903:1909	the lipid digestion profile	1883:1909	the lipid digestion profile	1883:1909	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	1	15	theme	structuring	219:229	arg1	agents					231:236	different structuring agents	209:236	different structuring agents	209:236	This research demonstrates the ability to direct the rate and extent of lipid hydrolysis of oleogels using a combination of different structuring agents.
32793939	4	16	theme	high	642:645	arg1	temperatures					647:658	high temperatures	642:658	high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures	642:730	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	4	16	theme	high	642:645	arg1	°C					666:667	∼100 °C	661:667	∼100 °C	661:667	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	5	17	theme	gel	828:830	arg1	networks					832:839	two gel networks	824:839	two gel networks	824:839	Such a profile suggests the formation of two gel networks, with the polymer network acting as a platform for E471 crystallization.
32793939	4	18	from	temperatures	719:730	arg1	transition					701:710	a soft-to-hard gel transition	682:710	a soft-to-hard gel transition at low temperatures	682:730	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	6	19	theme	typical	1090:1096	arg1	maximum					1098:1104	a typical maximum	1088:1104	a typical maximum at 7 : 3 E471 : EC 20 cP ratio	1088:1135	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	4	20	theme	=	633:633	arg1	G					635:635	G' = G	630:635	G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures	630:730	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	2	21	theme	ethyl	255:259	arg1	cellulose					261:269	ethyl cellulose	255:269	ethyl cellulose (EC) (20 cP and 45 cP)	255:292	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	2	21	theme	ethyl	255:259	arg1	EC					272:273	EC	272:273	EC	272:273	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	6	22	theme	Mechanical	914:923	arg1	analysis					925:932	Mechanical analysis	914:932	Mechanical analysis	914:932	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	12	23	theme	new	1838:1840	arg1	systems					1854:1860	new fat mimetic systems	1838:1860	new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase	1838:1975	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	1	24	theme	hydrolysis	163:172	arg1	rate					138:141	rate	138:141	rate	138:141	This research demonstrates the ability to direct the rate and extent of lipid hydrolysis of oleogels using a combination of different structuring agents.
32793939	1	24	theme	hydrolysis	163:172	arg1	extent					147:152	extent	147:152	extent	147:152	This research demonstrates the ability to direct the rate and extent of lipid hydrolysis of oleogels using a combination of different structuring agents.
32793939	8	25	theme	agent	1320:1324	arg1	effect					1294:1299	an effect	1291:1299	an effect of the structuring agent used on the lipolysis profile	1291:1354	Maximum lipolysis in the order of EC < E471 : EC < E471 was obtained, implying an effect of the structuring agent used on the lipolysis profile.
32793939	1	26	dep	rate	138:141	arg1	the					134:136	the	134:136	the	134:136	This research demonstrates the ability to direct the rate and extent of lipid hydrolysis of oleogels using a combination of different structuring agents.
32793939	8	27	from	effect	1294:1299	arg1	profile					1348:1354	the lipolysis profile	1334:1354	the lipolysis profile	1334:1354	Maximum lipolysis in the order of EC < E471 : EC < E471 was obtained, implying an effect of the structuring agent used on the lipolysis profile.
32793939	4	28	dep	G	635:635	arg1	°C					736:737	∼30 °C	732:737	∼30 °C	732:737	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	4	29	theme	gel	697:699	arg1	transition					701:710	a soft-to-hard gel transition	682:710	a soft-to-hard gel transition at low temperatures	682:730	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	9	30	theme	kinetics	1371:1378	arg1	analysis					1380:1387	A first-order kinetics analysis	1357:1387	A first-order kinetics analysis fitted to the lipolysis profiles	1357:1420	A first-order kinetics analysis fitted to the lipolysis profiles demonstrated rate constant values in the order of E471 < E471 : EC < EC.
32793939	7	31	theme	 EC	1192:1194	arg1	mixtures					1202:1209	E471 : EC 45 cP mixtures	1186:1209	E471 : EC 45 cP mixtures	1186:1209	No significant additive effect was observed for E471 : EC 45 cP mixtures.
32793939	12	32	attach	present	1952:1958	arg1	phase					1971:1975	the oil phase	1963:1975	the oil phase	1963:1975	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	12	32	attach	present	1952:1958	arg2	components					1941:1950	hydrophobic components	1929:1950	hydrophobic components present in the oil phase	1929:1975	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	8	33	theme	lipolysis	1338:1346	arg1	profile					1348:1354	the lipolysis profile	1334:1354	the lipolysis profile	1334:1354	Maximum lipolysis in the order of EC < E471 : EC < E471 was obtained, implying an effect of the structuring agent used on the lipolysis profile.
32793939	7	34	theme	E471 	1186:1190	arg1	mixtures					1202:1209	E471 : EC 45 cP mixtures	1186:1209	E471 : EC 45 cP mixtures	1186:1209	No significant additive effect was observed for E471 : EC 45 cP mixtures.
32793939	0	35	theme	intestinal	18:27	arg1	digestibility					29:41	lipid intestinal digestibility	12:41	lipid intestinal digestibility using various oil structuring mechanisms	12:82	Controlling lipid intestinal digestibility using various oil structuring mechanisms.
32793939	11	36	theme	gel	1767:1769	arg1	composition					1771:1781	gel composition	1767:1781	gel composition	1767:1781	Overall, the results demonstrate the ability to control gel properties and hydrolysis by manipulating gel composition.
32793939	8	37	theme	<	1249:1249	arg1	E471 					1251:1255	EC < E471 	1246:1255	EC < E471 	1246:1255	Maximum lipolysis in the order of EC < E471 : EC < E471 was obtained, implying an effect of the structuring agent used on the lipolysis profile.
32793939	0	38	theme	oil	57:59	arg1	mechanisms					73:82	various oil structuring mechanisms	49:82	various oil structuring mechanisms	49:82	Controlling lipid intestinal digestibility using various oil structuring mechanisms.
32793939	7	39	theme	significant	1141:1151	arg1	effect					1162:1167	No significant additive effect	1138:1167	No significant additive effect	1138:1167	No significant additive effect was observed for E471 : EC 45 cP mixtures.
32793939	10	40	theme	TAG	1646:1648	arg1	accessibility					1650:1662	liquid TAG accessibility	1639:1662	liquid TAG accessibility	1639:1662	Such behavior was attributed to the oil state, liquid vs. solid, and the network strength, both of which limit the lipase activity by hindering liquid TAG accessibility.
32793939	2	41	theme	commercial	298:307	arg1	mixture					309:315	commercial mixture	298:315	commercial mixture of mono and di-glycerides (E471)	298:348	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	1	42	theme	agents	231:236	arg1	combination					194:204	a combination	192:204	a combination of different structuring agents	192:236	This research demonstrates the ability to direct the rate and extent of lipid hydrolysis of oleogels using a combination of different structuring agents.
32793939	2	43	from	ratios	364:369	arg1	Combinations					239:250	Combinations	239:250	Combinations	239:250	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	6	44	theme	simple	1003:1008	arg1	addition					1010:1017	the simple addition	999:1017	the simple addition of each component contribution	999:1048	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	4	45	theme	system	557:562	arg1	profile					533:539	The gelation profile	520:539	The gelation profile of the combined system	520:562	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	12	46	theme	components	1941:1950	arg1	profile					1903:1909	the lipid digestion profile	1883:1909	the lipid digestion profile	1883:1909	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	12	46	theme	components	1941:1950	arg1	release					1918:1924	the release	1914:1924	the release of hydrophobic components present in the oil phase	1914:1975	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	12	47	from	present	1952:1958	arg1	phase					1971:1975	the oil phase	1963:1975	the oil phase	1963:1975	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	9	48	dep	E471 	1479:1483	arg1	EC					1491:1492	 EC < EC	1485:1492	E471 < E471 : EC < EC	1472:1492	A first-order kinetics analysis fitted to the lipolysis profiles demonstrated rate constant values in the order of E471 < E471 : EC < EC.
32793939	12	49	theme	oil	1967:1969	arg1	phase					1971:1975	the oil phase	1963:1975	the oil phase	1963:1975	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	10	50	theme	liquid	1542:1547	arg1	state					1535:1539	the oil state	1527:1539	the oil state	1527:1539	Such behavior was attributed to the oil state, liquid vs. solid, and the network strength, both of which limit the lipase activity by hindering liquid TAG accessibility.
32793939	6	51	theme	cP	1128:1129	arg1	ratio					1131:1135	7 : 3 E471 : EC 20 cP ratio	1109:1135	7 : 3 E471 : EC 20 cP ratio	1109:1135	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	3	52	theme	physical	474:481	arg1	properties					483:492	gel physical properties	470:492	gel physical properties	470:492	The results suggest that the combination of E471 and EC significantly affects both gel physical properties and intestinal lipolysis.
32793939	12	53	theme	digestion	1893:1901	arg1	profile					1903:1909	the lipid digestion profile	1883:1909	the lipid digestion profile	1883:1909	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	6	54	theme	 EC	1121:1123	arg1	ratio					1131:1135	7 : 3 E471 : EC 20 cP ratio	1109:1135	7 : 3 E471 : EC 20 cP ratio	1109:1135	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	6	55	from	gels	949:952	arg1	mixture					977:983	the E471 : EC 20 cP mixture	957:983	the E471 : EC 20 cP mixture	957:983	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	8	56	dep	lipolysis	1220:1228	arg1	E471					1263:1266	E471	1263:1266	E471	1263:1266	Maximum lipolysis in the order of EC < E471 : EC < E471 was obtained, implying an effect of the structuring agent used on the lipolysis profile.
32793939	4	57	theme	E471	761:764	arg1	crystallization					766:780	E471 crystallization	761:780	E471 crystallization	761:780	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	10	58	theme	solid	1553:1557	arg1	state					1535:1539	the oil state	1527:1539	the oil state	1527:1539	Such behavior was attributed to the oil state, liquid vs. solid, and the network strength, both of which limit the lipase activity by hindering liquid TAG accessibility.
32793939	6	59	theme	component	1027:1035	arg1	contribution					1037:1048	each component contribution	1022:1048	each component contribution	1022:1048	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	4	60	theme	sol-gel	584:590	arg1	transition					592:601	the EC sol-gel transition	577:601	the EC sol-gel transition	577:601	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	3	61	theme	EC	440:441	arg1	combination					416:426	the combination	412:426	the combination of E471 and EC	412:441	The results suggest that the combination of E471 and EC significantly affects both gel physical properties and intestinal lipolysis.
32793939	9	62	theme	<	1489:1489	arg1	EC					1491:1492	 EC < EC	1485:1492	E471 < E471 : EC < EC	1472:1492	A first-order kinetics analysis fitted to the lipolysis profiles demonstrated rate constant values in the order of E471 < E471 : EC < EC.
32793939	11	63	theme	gel	1721:1723	arg1	properties					1725:1734	gel properties	1721:1734	gel properties	1721:1734	Overall, the results demonstrate the ability to control gel properties and hydrolysis by manipulating gel composition.
32793939	12	64	from	phase	1971:1975	arg1	present					1952:1958	present	1952:1958	present	1952:1958	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	1	65	theme	different	209:217	arg1	agents					231:236	different structuring agents	209:236	different structuring agents	209:236	This research demonstrates the ability to direct the rate and extent of lipid hydrolysis of oleogels using a combination of different structuring agents.
32793939	10	66	theme	network	1568:1574	arg1	strength					1576:1583	the network strength	1564:1583	the network strength	1564:1583	Such behavior was attributed to the oil state, liquid vs. solid, and the network strength, both of which limit the lipase activity by hindering liquid TAG accessibility.
32793939	12	67	theme	fat	1842:1844	arg1	systems					1854:1860	new fat mimetic systems	1838:1860	new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase	1838:1975	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	5	68	theme	networks	832:839	arg1	formation					811:819	the formation	807:819	the formation of two gel networks	807:839	Such a profile suggests the formation of two gel networks, with the polymer network acting as a platform for E471 crystallization.
32793939	6	69	theme	harder	942:947	arg1	gels					949:952	harder gels	942:952	harder gels in the E471 : EC 20 cP mixture	942:983	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	2	70	theme	mixture	309:315	arg1	Combinations					239:250	Combinations	239:250	Combinations	239:250	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	2	71	theme	cellulose	261:269	arg1	Combinations					239:250	Combinations	239:250	Combinations	239:250	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	8	72	theme	structuring	1308:1318	arg1	agent					1320:1324	the structuring agent	1304:1324	the structuring agent used	1304:1329	Maximum lipolysis in the order of EC < E471 : EC < E471 was obtained, implying an effect of the structuring agent used on the lipolysis profile.
32793939	7	73	theme	cP	1199:1200	arg1	mixtures					1202:1209	E471 : EC 45 cP mixtures	1186:1209	E471 : EC 45 cP mixtures	1186:1209	No significant additive effect was observed for E471 : EC 45 cP mixtures.
32793939	1	74	theme	lipid	157:161	arg1	hydrolysis					163:172	lipid hydrolysis	157:172	lipid hydrolysis of oleogels using a combination of different structuring agents	157:236	This research demonstrates the ability to direct the rate and extent of lipid hydrolysis of oleogels using a combination of different structuring agents.
32793939	9	75	theme	first-order	1359:1369	arg1	analysis					1380:1387	A first-order kinetics analysis	1357:1387	A first-order kinetics analysis fitted to the lipolysis profiles	1357:1420	A first-order kinetics analysis fitted to the lipolysis profiles demonstrated rate constant values in the order of E471 < E471 : EC < EC.
32793939	6	76	theme	cP	974:975	arg1	mixture					977:983	the E471 : EC 20 cP mixture	957:983	the E471 : EC 20 cP mixture	957:983	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	4	77	theme	soft-to-hard	684:695	arg1	transition					701:710	a soft-to-hard gel transition	682:710	a soft-to-hard gel transition at low temperatures	682:730	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	0	78	theme	lipid	12:16	arg1	digestibility					29:41	lipid intestinal digestibility	12:41	lipid intestinal digestibility using various oil structuring mechanisms	12:82	Controlling lipid intestinal digestibility using various oil structuring mechanisms.
32793939	6	79	theme	 EC	967:969	arg1	mixture					977:983	the E471 : EC 20 cP mixture	957:983	the E471 : EC 20 cP mixture	957:983	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	8	80	theme	Maximum	1212:1218	arg1	lipolysis					1220:1228	Maximum lipolysis	1212:1228	Maximum lipolysis in the order of EC < E471 : EC < E471	1212:1266	Maximum lipolysis in the order of EC < E471 : EC < E471 was obtained, implying an effect of the structuring agent used on the lipolysis profile.
32793939	5	81	theme	polymer	851:857	arg1	network					859:865	the polymer network	847:865	the polymer network acting as a platform for E471 crystallization	847:911	Such a profile suggests the formation of two gel networks, with the polymer network acting as a platform for E471 crystallization.
32793939	6	82	theme	E471 	961:965	arg1	mixture					977:983	the E471 : EC 20 cP mixture	957:983	the E471 : EC 20 cP mixture	957:983	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	4	83	theme	gelation	524:531	arg1	profile					533:539	The gelation profile	520:539	The gelation profile of the combined system	520:562	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	0	84	theme	various	49:55	arg1	mechanisms					73:82	various oil structuring mechanisms	49:82	various oil structuring mechanisms	49:82	Controlling lipid intestinal digestibility using various oil structuring mechanisms.
32793939	9	85	theme	lipolysis	1403:1411	arg1	profiles					1413:1420	the lipolysis profiles	1399:1420	the lipolysis profiles	1399:1420	A first-order kinetics analysis fitted to the lipolysis profiles demonstrated rate constant values in the order of E471 < E471 : EC < EC.
32793939	7	86	theme	additive	1153:1160	arg1	effect					1162:1167	No significant additive effect	1138:1167	No significant additive effect	1138:1167	No significant additive effect was observed for E471 : EC 45 cP mixtures.
32793939	10	87	theme	lipase	1610:1615	arg1	activity					1617:1624	the lipase activity	1606:1624	the lipase activity	1606:1624	Such behavior was attributed to the oil state, liquid vs. solid, and the network strength, both of which limit the lipase activity by hindering liquid TAG accessibility.
32793939	12	88	theme	present	1952:1958	arg1	components					1941:1950	hydrophobic components	1929:1950	hydrophobic components present in the oil phase	1929:1975	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	2	89	theme	different	354:362	arg1	ratios					364:369	different ratios	354:369	different ratios	354:369	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	0	90	theme	structuring	61:71	arg1	mechanisms					73:82	various oil structuring mechanisms	49:82	various oil structuring mechanisms	49:82	Controlling lipid intestinal digestibility using various oil structuring mechanisms.
32793939	12	91	theme	rational	1789:1796	arg1	design					1798:1803	Such rational design	1784:1803	Such rational design	1784:1803	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	2	92	theme	di-glycerides	329:341	arg1	mixture					309:315	commercial mixture	298:315	commercial mixture of mono and di-glycerides (E471)	298:348	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	2	92	theme	di-glycerides	329:341	arg1	cellulose					261:269	ethyl cellulose	255:269	ethyl cellulose (EC) (20 cP and 45 cP)	255:292	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	2	92	theme	di-glycerides	329:341	arg1	EC					272:273	EC	272:273	EC	272:273	Combinations of ethyl cellulose (EC) (20 cP and 45 cP) and commercial mixture of mono and di-glycerides (E471), at different ratios, were examined.
32793939	8	93	theme	EC	1246:1247	arg1	E471 					1251:1255	EC < E471 	1246:1255	EC < E471 	1246:1255	Maximum lipolysis in the order of EC < E471 : EC < E471 was obtained, implying an effect of the structuring agent used on the lipolysis profile.
32793939	10	94	theme	Such	1495:1498	arg1	behavior					1500:1507	Such behavior	1495:1507	Such behavior	1495:1507	Such behavior was attributed to the oil state, liquid vs. solid, and the network strength, both of which limit the lipase activity by hindering liquid TAG accessibility.
32793939	12	95	theme	hydrophobic	1929:1939	arg1	components					1941:1950	hydrophobic components	1929:1950	hydrophobic components present in the oil phase	1929:1975	Such rational design can be exploited when developing new fat mimetic systems aimed at controlling the lipid digestion profile or the release of hydrophobic components present in the oil phase.
32793939	9	96	theme	constant	1440:1447	arg1	values					1449:1454	rate constant values	1435:1454	rate constant values	1435:1454	A first-order kinetics analysis fitted to the lipolysis profiles demonstrated rate constant values in the order of E471 < E471 : EC < EC.
32793939	10	97	theme	liquid	1639:1644	arg1	accessibility					1650:1662	liquid TAG accessibility	1639:1662	liquid TAG accessibility	1639:1662	Such behavior was attributed to the oil state, liquid vs. solid, and the network strength, both of which limit the lipase activity by hindering liquid TAG accessibility.
32793939	8	98	theme	E471 	1251:1255	arg1	order					1237:1241	the order	1233:1241	the order of EC < E471 	1233:1255	Maximum lipolysis in the order of EC < E471 : EC < E471 was obtained, implying an effect of the structuring agent used on the lipolysis profile.
32793939	3	99	theme	E471	431:434	arg1	combination					416:426	the combination	412:426	the combination of E471 and EC	412:441	The results suggest that the combination of E471 and EC significantly affects both gel physical properties and intestinal lipolysis.
32793939	6	100	from	ratio	1131:1135	arg1	maximum					1098:1104	a typical maximum	1088:1104	a typical maximum at 7 : 3 E471 : EC 20 cP ratio	1088:1135	Mechanical analysis reveals harder gels in the E471 : EC 20 cP mixture compared with the simple addition of each component contribution, suggesting a synergistic effect with a typical maximum at 7 : 3 E471 : EC 20 cP ratio.
32793939	4	101	theme	EC	581:582	arg1	transition					592:601	the EC sol-gel transition	577:601	the EC sol-gel transition	577:601	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	4	102	theme	low	715:717	arg1	temperatures					719:730	low temperatures	715:730	low temperatures	715:730	The gelation profile of the combined system demonstrated the EC sol-gel transition, which is characterized by G' = G'' at high temperatures (∼100 °C) followed by a soft-to-hard gel transition at low temperatures ∼30 °C, which corresponds to E471 crystallization.
32793939	3	103	theme	gel	470:472	arg1	properties					483:492	gel physical properties	470:492	gel physical properties	470:492	The results suggest that the combination of E471 and EC significantly affects both gel physical properties and intestinal lipolysis.
34119549	4	0	theme	Fe3O4	709:713	arg1	134.38					754:759	134.38	754:759	134.38	754:759	And the maximum sorption capacities of PEI-CNFs@Fe3O4 towards Ni(II), Cu(II) and Cd(II) were 134.38, 93.71 and 173.56 mg g-1, respectively.
34119549	4	0	theme	Fe3O4	709:713	arg1	capacities					686:695	the maximum sorption capacities	665:695	the maximum sorption capacities of PEI-CNFs@Fe3O4 towards Ni(II), Cu(II) and Cd(II)	665:747	And the maximum sorption capacities of PEI-CNFs@Fe3O4 towards Ni(II), Cu(II) and Cd(II) were 134.38, 93.71 and 173.56 mg g-1, respectively.
34119549	8	1	theme	water	1615:1619	arg1	treatment					1574:1582	the treatment	1570:1582	the treatment of multi-heavy metals polluted water	1570:1619	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	0	2	theme	single-component	126:141	arg1	systems					163:169	single-component and multi-component systems	126:169	single-component and multi-component systems	126:169	Fabrication of polyethylenimine functionalized magnetic cellulose nanofibers for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	1	3	theme	Cd	361:362	arg1	sorption					330:337	the sorption	326:337	the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems	326:414	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	1	4	theme	PEI-CNFs	252:259	arg1	composites					240:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites	172:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4)	172:266	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	1	4	theme	PEI-CNFs	252:259	arg1	Fe3O4					261:265	PEI-CNFs@Fe3O4	252:265	PEI-CNFs@Fe3O4	252:265	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	0	5	theme	multi-component	147:161	arg1	systems					163:169	single-component and multi-component systems	126:169	single-component and multi-component systems	126:169	Fabrication of polyethylenimine functionalized magnetic cellulose nanofibers for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	4	6	theme	PEI-CNFs	700:707	arg1	Fe3O4					709:713	PEI-CNFs@Fe3O4	700:713	PEI-CNFs@Fe3O4 towards Ni(II), Cu(II) and Cd(II)	700:747	And the maximum sorption capacities of PEI-CNFs@Fe3O4 towards Ni(II), Cu(II) and Cd(II) were 134.38, 93.71 and 173.56 mg g-1, respectively.
34119549	7	7	theme	Cd	1322:1323	arg1	capacities					1289:1298	the sorption capacities	1276:1298	the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II))	1276:1354	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	4	8	theme	@	708:708	arg1	Fe3O4					709:713	PEI-CNFs@Fe3O4	700:713	PEI-CNFs@Fe3O4 towards Ni(II), Cu(II) and Cd(II)	700:747	And the maximum sorption capacities of PEI-CNFs@Fe3O4 towards Ni(II), Cu(II) and Cd(II) were 134.38, 93.71 and 173.56 mg g-1, respectively.
34119549	2	9	theme	model	462:466	arg1	fittings					468:475	model fittings	462:475	model fittings	462:475	The batch experiments, spectral analyses and model fittings were used to reveal the sorption properties.
34119549	3	10	theme	@	575:575	arg1	Fe3O4					576:580	PEI-CNFs@Fe3O4	567:580	PEI-CNFs@Fe3O4	567:580	The sorption of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 all conformed to the Langmuir isotherm and pseudo-second-order kinetic models.
34119549	0	11	theme	Cu	105:106	arg1	sorption					85:92	the sorption	81:92	the sorption of Ni(II), Cu(II) and Cd(II)	81:121	Fabrication of polyethylenimine functionalized magnetic cellulose nanofibers for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	1	12	theme	Ni	342:343	arg1	sorption					330:337	the sorption	326:337	the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems	326:414	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	3	13	theme	Langmuir	603:610	arg1	isotherm					612:619	the Langmuir isotherm	599:619	the Langmuir isotherm	599:619	The sorption of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 all conformed to the Langmuir isotherm and pseudo-second-order kinetic models.
34119549	8	14	theme	@	1380:1380	arg1	Fe3O4					1381:1385	PEI-CNFs@Fe3O4	1372:1385	PEI-CNFs@Fe3O4	1372:1385	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	1	15	theme	Novel	172:176	arg1	composites					240:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites	172:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4)	172:266	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	1	15	theme	Novel	172:176	arg1	Fe3O4					261:265	PEI-CNFs@Fe3O4	252:265	PEI-CNFs@Fe3O4	252:265	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	7	16	theme	PEI-CNFs	1223:1230	arg1	Fe3O4					1232:1236	PEI-CNFs@Fe3O4	1223:1236	PEI-CNFs@Fe3O4	1223:1236	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	5	17	theme	sorption	810:817	arg1	mechanism					819:827	The main sorption mechanism	801:827	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4	801:874	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	5	17	theme	sorption	810:817	arg1	complexation					898:909	the strong surface complexation	879:909	the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions	879:988	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	7	18	theme	Cu	1311:1312	arg1	capacities					1289:1298	the sorption capacities	1276:1298	the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II))	1276:1354	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	7	19	theme	ability	1210:1216	arg1	size					1142:1145	the size	1138:1145	the size of the ionic radius	1138:1165	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	7	19	theme	ability	1210:1216	arg1	reasons					1246:1252	the reasons	1242:1252	the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II))	1242:1354	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	7	19	theme	ability	1210:1216	arg1	strength					1175:1182	the strength	1171:1182	the strength of the surface complexing ability with PEI-CNFs@Fe3O4	1171:1236	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	3	20	theme	kinetic	645:651	arg1	models					653:658	pseudo-second-order kinetic models	625:658	pseudo-second-order kinetic models	625:658	The sorption of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 all conformed to the Langmuir isotherm and pseudo-second-order kinetic models.
34119549	7	21	theme	surface	1191:1197	arg1	ability					1210:1216	the surface complexing ability	1187:1216	the surface complexing ability with PEI-CNFs@Fe3O4	1187:1236	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	2	22	used	used	482:485	arg2	experiments					427:437	The batch experiments	417:437	The batch experiments	417:437	The batch experiments, spectral analyses and model fittings were used to reveal the sorption properties.
34119549	2	22	used	used	482:485	arg2	fittings					468:475	model fittings	462:475	model fittings	462:475	The batch experiments, spectral analyses and model fittings were used to reveal the sorption properties.
34119549	2	22	used	used	482:485	arg2	analyses					449:456	spectral analyses	440:456	spectral analyses	440:456	The batch experiments, spectral analyses and model fittings were used to reveal the sorption properties.
34119549	5	23	theme	groups	947:952	arg1	complexation					898:909	the strong surface complexation	879:909	the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions	879:988	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	5	23	theme	groups	947:952	arg1	mechanism					819:827	The main sorption mechanism	801:827	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4	801:874	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	5	24	from	mechanism	819:827	arg1	Fe3O4					870:874	PEI-CNFs@Fe3O4	861:874	PEI-CNFs@Fe3O4	861:874	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	1	25	theme	raw	308:310	arg1	materials					312:320	the raw materials	304:320	the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems	304:414	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	1	25	theme	raw	308:310	arg1	peels					295:299	banana peels	288:299	banana peels	288:299	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	7	26	dep	 > Cu	1345:1349	arg1	II					1342:1343	II	1342:1343	II	1342:1343	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	5	27	theme	Ni	959:960	arg1	ions					985:988	Ni(II), Cu(II) and Cd(II) ions	959:988	Ni(II), Cu(II) and Cd(II) ions	959:988	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	8	28	theme	simple	1425:1430	arg1	preparation					1432:1442	simple preparation	1425:1442	simple preparation	1425:1442	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	5	29	theme	Cu	840:841	arg1	mechanism					819:827	The main sorption mechanism	801:827	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4	801:874	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	5	29	theme	Cu	840:841	arg1	complexation					898:909	the strong surface complexation	879:909	the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions	879:988	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	7	30	theme	sorption	1280:1287	arg1	capacities					1289:1298	the sorption capacities	1276:1298	the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II))	1276:1354	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	7	31	theme	radius	1160:1165	arg1	size					1142:1145	the size	1138:1145	the size of the ionic radius	1138:1165	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	7	31	theme	radius	1160:1165	arg1	reasons					1246:1252	the reasons	1242:1252	the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II))	1242:1354	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	7	31	theme	radius	1160:1165	arg1	strength					1175:1182	the strength	1171:1182	the strength of the surface complexing ability with PEI-CNFs@Fe3O4	1171:1236	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	2	32	theme	batch	421:425	arg1	experiments					427:437	The batch experiments	417:437	The batch experiments	417:437	The batch experiments, spectral analyses and model fittings were used to reveal the sorption properties.
34119549	0	33	from	nanofibers	66:75	arg1	systems					163:169	single-component and multi-component systems	126:169	single-component and multi-component systems	126:169	Fabrication of polyethylenimine functionalized magnetic cellulose nanofibers for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	5	34	theme	Cd	978:979	arg1	ions					985:988	Ni(II), Cu(II) and Cd(II) ions	959:988	Ni(II), Cu(II) and Cd(II) ions	959:988	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	8	35	theme	capacity	1516:1523	arg1	advantages					1401:1410	the advantages	1397:1410	the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity	1397:1523	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	8	36	theme	magnetic	1450:1457	arg1	separation					1459:1468	easy magnetic separation	1445:1468	easy magnetic separation	1445:1468	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	1	37	theme	@	260:260	arg1	composites					240:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites	172:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4)	172:266	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	1	37	theme	@	260:260	arg1	Fe3O4					261:265	PEI-CNFs@Fe3O4	252:265	PEI-CNFs@Fe3O4	252:265	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	0	38	theme	polyethylenimine	15:30	arg1	Fabrication					0:10	Fabrication	0:10	Fabrication of polyethylenimine	0:30	Fabrication of polyethylenimine functionalized magnetic cellulose nanofibers for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	0	39	theme	magnetic	47:54	arg1	nanofibers					66:75	magnetic cellulose nanofibers	47:75	magnetic cellulose nanofibers for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems	47:169	Fabrication of polyethylenimine functionalized magnetic cellulose nanofibers for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	8	40	theme	friendliness	1485:1496	arg1	advantages					1401:1410	the advantages	1397:1410	the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity	1397:1523	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	8	41	theme	application	1546:1556	arg1	prospect					1558:1565	a broad application prospect	1538:1565	a broad application prospect	1538:1565	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	4	42	theme	maximum	669:675	arg1	134.38					754:759	134.38	754:759	134.38	754:759	And the maximum sorption capacities of PEI-CNFs@Fe3O4 towards Ni(II), Cu(II) and Cd(II) were 134.38, 93.71 and 173.56 mg g-1, respectively.
34119549	4	42	theme	maximum	669:675	arg1	capacities					686:695	the maximum sorption capacities	665:695	the maximum sorption capacities of PEI-CNFs@Fe3O4 towards Ni(II), Cu(II) and Cd(II)	665:747	And the maximum sorption capacities of PEI-CNFs@Fe3O4 towards Ni(II), Cu(II) and Cd(II) were 134.38, 93.71 and 173.56 mg g-1, respectively.
34119549	1	43	theme	multi-component	392:406	arg1	systems					408:414	single-component and multi-component systems	371:414	single-component and multi-component systems	371:414	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	6	44	theme	PEI	1023:1025	arg1	introduction					1007:1018	the introduction	1003:1018	the introduction of PEI	1003:1025	Especially, the introduction of PEI contributed to the improvement in the sorption capacities of PEI-CNFs@Fe3O4 towards the heavy metals.
34119549	5	45	theme	PEI-CNFs	861:868	arg1	Fe3O4					870:874	PEI-CNFs@Fe3O4	861:874	PEI-CNFs@Fe3O4	861:874	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	5	46	theme	main	805:808	arg1	mechanism					819:827	The main sorption mechanism	801:827	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4	801:874	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	5	46	theme	main	805:808	arg1	complexation					898:909	the strong surface complexation	879:909	the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions	879:988	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	7	47	theme	 > Ni	1336:1340	arg1	 > Cu					1345:1349	Cd(II) > Ni(II) > Cu(II)	1330:1353	Cd(II) > Ni(II) > Cu(II)	1330:1353	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	7	47	theme	 > Ni	1336:1340	arg1	Cd					1322:1323	Cd(II)	1322:1327	Cd(II) (Cd(II) > Ni(II) > Cu(II))	1322:1354	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	5	48	with	complexation	898:909	arg1	ions					985:988	Ni(II), Cu(II) and Cd(II) ions	959:988	Ni(II), Cu(II) and Cd(II) ions	959:988	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	5	49	theme	amino	918:922	arg1	groups					947:952	the amino, carboxyl and hydroxyl groups	914:952	groups	947:952	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	3	50	theme	Cu	546:547	arg1	sorption					526:533	The sorption	522:533	The sorption of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4	522:580	The sorption of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 all conformed to the Langmuir isotherm and pseudo-second-order kinetic models.
34119549	6	51	theme	Fe3O4	1097:1101	arg1	capacities					1074:1083	the sorption capacities	1061:1083	the sorption capacities of PEI-CNFs@Fe3O4	1061:1101	Especially, the introduction of PEI contributed to the improvement in the sorption capacities of PEI-CNFs@Fe3O4 towards the heavy metals.
34119549	5	52	theme	carboxyl	925:932	arg1	groups					947:952	the amino, carboxyl and hydroxyl groups	914:952	groups	947:952	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	7	53	theme	Cd	1330:1331	arg1	 > Cu					1345:1349	Cd(II) > Ni(II) > Cu(II)	1330:1353	Cd(II) > Ni(II) > Cu(II)	1330:1353	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	7	53	theme	Cd	1330:1331	arg1	Cd					1322:1323	Cd(II)	1322:1327	Cd(II) (Cd(II) > Ni(II) > Cu(II))	1322:1354	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	8	54	theme	multi-heavy	1587:1597	arg1	water					1615:1619	multi-heavy metals polluted water	1587:1619	multi-heavy metals polluted water	1587:1619	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	6	55	theme	PEI-CNFs	1088:1095	arg1	Fe3O4					1097:1101	PEI-CNFs@Fe3O4	1088:1101	PEI-CNFs@Fe3O4	1088:1101	Especially, the introduction of PEI contributed to the improvement in the sorption capacities of PEI-CNFs@Fe3O4 towards the heavy metals.
34119549	1	56	theme	magnetic	231:238	arg1	composites					240:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites	172:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4)	172:266	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	1	56	theme	magnetic	231:238	arg1	Fe3O4					261:265	PEI-CNFs@Fe3O4	252:265	PEI-CNFs@Fe3O4	252:265	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	2	57	theme	sorption	501:508	arg1	properties					510:519	the sorption properties	497:519	the sorption properties	497:519	The batch experiments, spectral analyses and model fittings were used to reveal the sorption properties.
34119549	8	58	theme	polluted	1606:1613	arg1	water					1615:1619	multi-heavy metals polluted water	1587:1619	multi-heavy metals polluted water	1587:1619	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	3	59	theme	PEI-CNFs	567:574	arg1	Fe3O4					576:580	PEI-CNFs@Fe3O4	567:580	PEI-CNFs@Fe3O4	567:580	The sorption of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 all conformed to the Langmuir isotherm and pseudo-second-order kinetic models.
34119549	8	60	theme	high	1502:1505	arg1	capacity					1516:1523	high sorption capacity	1502:1523	high sorption capacity	1502:1523	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	4	61	theme	sorption	677:684	arg1	134.38					754:759	134.38	754:759	134.38	754:759	And the maximum sorption capacities of PEI-CNFs@Fe3O4 towards Ni(II), Cu(II) and Cd(II) were 134.38, 93.71 and 173.56 mg g-1, respectively.
34119549	4	61	theme	sorption	677:684	arg1	capacities					686:695	the maximum sorption capacities	665:695	the maximum sorption capacities of PEI-CNFs@Fe3O4 towards Ni(II), Cu(II) and Cd(II)	665:747	And the maximum sorption capacities of PEI-CNFs@Fe3O4 towards Ni(II), Cu(II) and Cd(II) were 134.38, 93.71 and 173.56 mg g-1, respectively.
34119549	1	62	theme	banana	288:293	arg1	materials					312:320	the raw materials	304:320	the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems	304:414	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	1	62	theme	banana	288:293	arg1	peels					295:299	banana peels	288:299	banana peels	288:299	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	8	63	theme	cost	1419:1422	arg1	advantages					1401:1410	the advantages	1397:1410	the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity	1397:1523	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	5	64	theme	surface	890:896	arg1	complexation					898:909	the strong surface complexation	879:909	the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions	879:988	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	5	64	theme	surface	890:896	arg1	mechanism					819:827	The main sorption mechanism	801:827	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4	801:874	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	8	65	theme	PEI-CNFs	1372:1379	arg1	Fe3O4					1381:1385	PEI-CNFs@Fe3O4	1372:1385	PEI-CNFs@Fe3O4	1372:1385	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	1	66	theme	single-component	371:386	arg1	systems					408:414	single-component and multi-component systems	371:414	single-component and multi-component systems	371:414	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	7	67	theme	@	1231:1231	arg1	Fe3O4					1232:1236	PEI-CNFs@Fe3O4	1223:1236	PEI-CNFs@Fe3O4	1223:1236	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	6	68	from	improvement	1046:1056	arg1	capacities					1074:1083	the sorption capacities	1061:1083	the sorption capacities of PEI-CNFs@Fe3O4	1061:1101	Especially, the introduction of PEI contributed to the improvement in the sorption capacities of PEI-CNFs@Fe3O4 towards the heavy metals.
34119549	2	69	theme	spectral	440:447	arg1	analyses					449:456	spectral analyses	440:456	spectral analyses	440:456	The batch experiments, spectral analyses and model fittings were used to reveal the sorption properties.
34119549	0	70	theme	Cd	116:117	arg1	sorption					85:92	the sorption	81:92	the sorption of Ni(II), Cu(II) and Cd(II)	81:121	Fabrication of polyethylenimine functionalized magnetic cellulose nanofibers for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	7	71	theme	complexing	1199:1208	arg1	ability					1210:1216	the surface complexing ability	1187:1216	the surface complexing ability with PEI-CNFs@Fe3O4	1187:1236	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	7	72	from	difference	1262:1271	arg1	capacities					1289:1298	the sorption capacities	1276:1298	the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II))	1276:1354	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	1	73	theme	Cu	350:351	arg1	sorption					330:337	the sorption	326:337	the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems	326:414	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	8	74	theme	separation	1459:1468	arg1	advantages					1401:1410	the advantages	1397:1410	the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity	1397:1523	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	8	75	theme	low	1415:1417	arg1	cost					1419:1422	low cost	1415:1422	low cost	1415:1422	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	5	76	theme	Ni	832:833	arg1	mechanism					819:827	The main sorption mechanism	801:827	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4	801:874	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	5	76	theme	Ni	832:833	arg1	complexation					898:909	the strong surface complexation	879:909	the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions	879:988	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	1	77	theme	polyethyleneimine	178:194	arg1	composites					240:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites	172:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4)	172:266	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	1	77	theme	polyethyleneimine	178:194	arg1	Fe3O4					261:265	PEI-CNFs@Fe3O4	252:265	PEI-CNFs@Fe3O4	252:265	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	5	78	theme	hydroxyl	938:945	arg1	groups					947:952	the amino, carboxyl and hydroxyl groups	914:952	groups	947:952	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	3	79	theme	pseudo-second-order	625:643	arg1	models					653:658	pseudo-second-order kinetic models	625:658	pseudo-second-order kinetic models	625:658	The sorption of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 all conformed to the Langmuir isotherm and pseudo-second-order kinetic models.
34119549	0	80	theme	Ni	97:98	arg1	sorption					85:92	the sorption	81:92	the sorption of Ni(II), Cu(II) and Cd(II)	81:121	Fabrication of polyethylenimine functionalized magnetic cellulose nanofibers for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	5	81	theme	Cd	851:852	arg1	mechanism					819:827	The main sorption mechanism	801:827	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4	801:874	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	5	81	theme	Cd	851:852	arg1	complexation					898:909	the strong surface complexation	879:909	the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions	879:988	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	8	82	theme	preparation	1432:1442	arg1	advantages					1401:1410	the advantages	1397:1410	the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity	1397:1523	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	7	83	with	ability	1210:1216	arg1	Fe3O4					1232:1236	PEI-CNFs@Fe3O4	1223:1236	PEI-CNFs@Fe3O4	1223:1236	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	7	84	theme	Ni	1303:1304	arg1	capacities					1289:1298	the sorption capacities	1276:1298	the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II))	1276:1354	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	7	85	theme	ionic	1154:1158	arg1	radius					1160:1165	the ionic radius	1150:1165	the ionic radius	1150:1165	Besides, the size of the ionic radius and the strength of the surface complexing ability with PEI-CNFs@Fe3O4 are the reasons for the difference in the sorption capacities of Ni(II), Cu(II) and Cd(II) (Cd(II) > Ni(II) > Cu(II)).
34119549	8	86	theme	easy	1445:1448	arg1	separation					1459:1468	easy magnetic separation	1445:1468	easy magnetic separation	1445:1468	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	3	87	from	sorption	526:533	arg1	Fe3O4					576:580	PEI-CNFs@Fe3O4	567:580	PEI-CNFs@Fe3O4	567:580	The sorption of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 all conformed to the Langmuir isotherm and pseudo-second-order kinetic models.
34119549	1	88	from	sorption	330:337	arg1	systems					408:414	single-component and multi-component systems	371:414	single-component and multi-component systems	371:414	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	5	89	theme	Cu	967:968	arg1	ions					985:988	Ni(II), Cu(II) and Cd(II) ions	959:988	Ni(II), Cu(II) and Cd(II) ions	959:988	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	8	90	theme	environmental	1471:1483	arg1	friendliness					1485:1496	environmental friendliness	1471:1496	environmental friendliness	1471:1496	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	8	91	theme	broad	1540:1544	arg1	prospect					1558:1565	a broad application prospect	1538:1565	a broad application prospect	1538:1565	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	0	92	theme	cellulose	56:64	arg1	nanofibers					66:75	magnetic cellulose nanofibers	47:75	magnetic cellulose nanofibers for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems	47:169	Fabrication of polyethylenimine functionalized magnetic cellulose nanofibers for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	5	93	theme	strong	883:888	arg1	complexation					898:909	the strong surface complexation	879:909	the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions	879:988	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	5	93	theme	strong	883:888	arg1	mechanism					819:827	The main sorption mechanism	801:827	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4	801:874	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	3	94	theme	Ni	538:539	arg1	sorption					526:533	The sorption	522:533	The sorption of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4	522:580	The sorption of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 all conformed to the Langmuir isotherm and pseudo-second-order kinetic models.
34119549	1	95	theme	cellulose	211:219	arg1	composites					240:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites	172:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4)	172:266	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	1	95	theme	cellulose	211:219	arg1	Fe3O4					261:265	PEI-CNFs@Fe3O4	252:265	PEI-CNFs@Fe3O4	252:265	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	8	96	theme	sorption	1507:1514	arg1	capacity					1516:1523	high sorption capacity	1502:1523	high sorption capacity	1502:1523	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	6	97	theme	heavy	1115:1119	arg1	metals					1121:1126	the heavy metals	1111:1126	the heavy metals	1111:1126	Especially, the introduction of PEI contributed to the improvement in the sorption capacities of PEI-CNFs@Fe3O4 towards the heavy metals.
34119549	5	98	theme	@	869:869	arg1	Fe3O4					870:874	PEI-CNFs@Fe3O4	861:874	PEI-CNFs@Fe3O4	861:874	The main sorption mechanism of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 is the strong surface complexation of the amino, carboxyl and hydroxyl groups with Ni(II), Cu(II) and Cd(II) ions.
34119549	1	99	theme	functionalized	196:209	arg1	composites					240:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites	172:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4)	172:266	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	1	99	theme	functionalized	196:209	arg1	Fe3O4					261:265	PEI-CNFs@Fe3O4	252:265	PEI-CNFs@Fe3O4	252:265	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	8	100	theme	metals	1599:1604	arg1	water					1615:1619	multi-heavy metals polluted water	1587:1619	multi-heavy metals polluted water	1587:1619	In conclusion, PEI-CNFs@Fe3O4 has shown the advantages of low cost, simple preparation, easy magnetic separation, environmental friendliness and high sorption capacity, thus having a broad application prospect in the treatment of multi-heavy metals polluted water.
34119549	3	101	theme	Cd	557:558	arg1	sorption					526:533	The sorption	522:533	The sorption of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4	522:580	The sorption of Ni(II), Cu(II) and Cd(II) on PEI-CNFs@Fe3O4 all conformed to the Langmuir isotherm and pseudo-second-order kinetic models.
34119549	6	102	theme	sorption	1065:1072	arg1	capacities					1074:1083	the sorption capacities	1061:1083	the sorption capacities of PEI-CNFs@Fe3O4	1061:1101	Especially, the introduction of PEI contributed to the improvement in the sorption capacities of PEI-CNFs@Fe3O4 towards the heavy metals.
34119549	6	103	theme	@	1096:1096	arg1	Fe3O4					1097:1101	PEI-CNFs@Fe3O4	1088:1101	PEI-CNFs@Fe3O4	1088:1101	Especially, the introduction of PEI contributed to the improvement in the sorption capacities of PEI-CNFs@Fe3O4 towards the heavy metals.
34119549	1	104	theme	nanofiber	221:229	arg1	composites					240:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites	172:249	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4)	172:266	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34119549	1	104	theme	nanofiber	221:229	arg1	Fe3O4					261:265	PEI-CNFs@Fe3O4	252:265	PEI-CNFs@Fe3O4	252:265	Novel polyethyleneimine functionalized cellulose nanofiber magnetic composites (PEI-CNFs@Fe3O4) were prepared using banana peels as the raw materials for the sorption of Ni(II), Cu(II) and Cd(II) in single-component and multi-component systems.
34051259	9	0	theme	other	1771:1775	arg1	drugs					1784:1788	other labile drugs	1771:1788	other labile drugs similar to aspirin in emergency situations	1771:1831	This CE and CPC approach in DOE can be used for delivery system design of other labile drugs similar to aspirin in emergency situations.
34051259	2	1	theme	predictable	522:532	arg1	control					534:540	predictable control	522:540	predictable control over drug release (DR)	522:563	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	9	2	theme	drugs	1784:1788	arg1	design					1761:1766	delivery system design	1745:1766	delivery system design of other labile drugs similar to aspirin in emergency situations	1745:1831	This CE and CPC approach in DOE can be used for delivery system design of other labile drugs similar to aspirin in emergency situations.
34051259	5	3	contain	has	829:831	arg1	CS					826:827	The CS	822:827	The CS	822:827	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	5	3	contain	has	829:831	arg2	angle					844:848	a low 1200 angle	833:848	a low 1200 angle	833:848	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	9	4	from	aspirin	1801:1807	arg1	situations					1822:1831	emergency situations	1812:1831	emergency situations	1812:1831	This CE and CPC approach in DOE can be used for delivery system design of other labile drugs similar to aspirin in emergency situations.
34051259	7	5	theme	%	1460:1460	arg1	deviation					1462:1470	20% deviation	1458:1470	20% deviation	1458:1470	The results of DOE to experimentally validated results were within 20% deviation.
34051259	8	6	theme	scanning	1571:1578	arg1	DSC					1593:1595	DSC	1593:1595	DSC	1593:1595	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	8	6	theme	scanning	1571:1578	arg1	calorimetry					1580:1590	differential scanning calorimetry	1558:1590	differential scanning calorimetry (DSC)	1558:1596	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	4	7	theme	than	782:785	arg1	mm					792:793	0.35 mm than 0.71 mm	774:793	0.35 mm than 0.71 mm	774:793	Among spherules, one with 0.35 mm than 0.71 mm shows required properties.
34051259	3	8	theme	cellulose	653:661	arg1	spherules					675:683	Ethyl cellulose (EC) Coated spherules	647:683	Ethyl cellulose (EC) Coated spherules (CS)	647:688	Subsequently, the granules containing ASP are converted to spherules and then to Ethyl cellulose (EC) Coated spherules (CS) by a novel bed coating during the rolling (BCDR) process.
34051259	3	8	theme	cellulose	653:661	arg1	CS					686:687	CS	686:687	CS	686:687	Subsequently, the granules containing ASP are converted to spherules and then to Ethyl cellulose (EC) Coated spherules (CS) by a novel bed coating during the rolling (BCDR) process.
34051259	0	9	theme	arbitrary	115:123	arg1	interface					125:133	arbitrary interface; applicable for emergency situations	115:170	arbitrary interface; applicable for emergency situations	115:170	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.
34051259	6	10	from	reduction	1188:1196	arg1	BR					1216:1217	BR	1216:1217	BR	1216:1217	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	6	10	from	reduction	1188:1196	arg1	release					1207:1213	burst release	1201:1213	burst release (BR)	1201:1218	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	2	11	theme	cumulative	479:488	arg1	CPC					510:512	CPC	510:512	CPC	510:512	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	2	11	theme	cumulative	479:488	arg1	coating					501:507	the cumulative percentage coating	475:507	the cumulative percentage coating (CPC)	475:513	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	7	12	theme	validated	1428:1436	arg1	results					1438:1444	experimentally validated results	1413:1444	experimentally validated results	1413:1444	The results of DOE to experimentally validated results were within 20% deviation.
34051259	9	13	used	used	1736:1739	arg2	approach					1713:1720	This CE and CPC approach	1697:1720	This CE and CPC approach in DOE	1697:1727	This CE and CPC approach in DOE can be used for delivery system design of other labile drugs similar to aspirin in emergency situations.
34051259	5	14	theme	repose	984:989	arg1	±					997:997	repose 29.69 ± 0.780	984:1003	repose 29.69 ± 0.780	984:1003	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	3	15	theme	Coated	668:673	arg1	spherules					675:683	Ethyl cellulose (EC) Coated spherules	647:683	Ethyl cellulose (EC) Coated spherules (CS)	647:688	Subsequently, the granules containing ASP are converted to spherules and then to Ethyl cellulose (EC) Coated spherules (CS) by a novel bed coating during the rolling (BCDR) process.
34051259	3	15	theme	Coated	668:673	arg1	CS					686:687	CS	686:687	CS	686:687	Subsequently, the granules containing ASP are converted to spherules and then to Ethyl cellulose (EC) Coated spherules (CS) by a novel bed coating during the rolling (BCDR) process.
34051259	6	16	theme	space	1318:1322	arg1	Design					1308:1313	Design	1308:1313	Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%)	1308:1373	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	3	17	theme	BCDR	733:736	arg1	process					739:745	the rolling (BCDR) process	720:745	the rolling (BCDR) process	720:745	Subsequently, the granules containing ASP are converted to spherules and then to Ethyl cellulose (EC) Coated spherules (CS) by a novel bed coating during the rolling (BCDR) process.
34051259	5	18	theme	smooth	878:883	arg1	cracks					901:906	smooth surface without cracks	878:906	smooth surface without cracks by scanning electron microscopy (SEM)	878:944	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	3	19	theme	rolling	724:730	arg1	process					739:745	the rolling (BCDR) process	720:745	the rolling (BCDR) process	720:745	Subsequently, the granules containing ASP are converted to spherules and then to Ethyl cellulose (EC) Coated spherules (CS) by a novel bed coating during the rolling (BCDR) process.
34051259	1	20	dep	design	240:245	arg1	the					236:238	the	236:238	the	236:238	This work attempts to resolve one of the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations, tailored to treat COVID-19.
34051259	6	21	theme	%	1186:1186	arg1	reduction					1188:1196	10% reduction	1184:1196	10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%	1184:1270	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	1	22	theme	spherule	284:291	arg1	design					240:245	design	240:245	design	240:245	This work attempts to resolve one of the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations, tailored to treat COVID-19.
34051259	1	22	theme	spherule	284:291	arg1	development					251:261	development	251:261	development	251:261	This work attempts to resolve one of the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations, tailored to treat COVID-19.
34051259	4	23	theme	required	801:808	arg1	properties					810:819	required properties	801:819	required properties	801:819	Among spherules, one with 0.35 mm than 0.71 mm shows required properties.
34051259	3	24	theme	bed	701:703	arg1	coating					705:711	a novel bed coating	693:711	a novel bed coating during the rolling (BCDR) process	693:745	Subsequently, the granules containing ASP are converted to spherules and then to Ethyl cellulose (EC) Coated spherules (CS) by a novel bed coating during the rolling (BCDR) process.
34051259	5	25	theme	electron	920:927	arg1	SEM					941:943	SEM	941:943	SEM	941:943	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	5	25	theme	electron	920:927	arg1	microscopy					929:938	scanning electron microscopy	911:938	scanning electron microscopy (SEM)	911:944	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	8	26	theme	crystal	1501:1507	arg1	structure					1509:1517	its crystal structure	1497:1517	its crystal structure	1497:1517	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	5	27	dep	Angle	975:979	arg1	%					1030:1030	Carr's index 6.73 ± 2.24%	1006:1030	Carr's index 6.73 ± 2.24%	1006:1030	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	5	27	dep	Angle	975:979	arg1	±					1054:1054	Hausner's Ratio 1.07 ± 0.03	1033:1059	Hausner's Ratio 1.07 ± 0.03	1033:1059	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	6	28	theme	structure-dependent	1104:1122	arg1	control					1124:1130	certain structure-dependent control	1096:1130	certain structure-dependent control over release	1096:1143	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	0	29	theme	aspirin	41:47	arg1	spherules					49:57	Ethyl cellulose coated sustained release aspirin spherules	0:57	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.	0:171	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.
34051259	9	30	theme	similar	1790:1796	arg1	drugs					1784:1788	other labile drugs	1771:1788	other labile drugs similar to aspirin in emergency situations	1771:1831	This CE and CPC approach in DOE can be used for delivery system design of other labile drugs similar to aspirin in emergency situations.
34051259	0	31	theme	Ethyl	0:4	arg1	spherules					49:57	Ethyl cellulose coated sustained release aspirin spherules	0:57	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.	0:171	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.
34051259	8	32	theme	X-ray	1529:1533	arg1	PXRD					1548:1551	PXRD	1548:1551	PXRD	1548:1551	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	8	32	theme	X-ray	1529:1533	arg1	diffraction					1535:1545	powder X-ray diffraction	1522:1545	powder X-ray diffraction (PXRD)	1522:1552	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	0	33	theme	coated	16:21	arg1	spherules					49:57	Ethyl cellulose coated sustained release aspirin spherules	0:57	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.	0:171	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.
34051259	5	34	theme	29.69	991:995	arg1	±					997:997	repose 29.69 ± 0.780	984:1003	repose 29.69 ± 0.780	984:1003	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	4	35	with	one	765:767	arg1	mm					792:793	0.35 mm than 0.71 mm	774:793	0.35 mm than 0.71 mm	774:793	Among spherules, one with 0.35 mm than 0.71 mm shows required properties.
34051259	2	36	theme	efficiency	433:442	arg1	CE					446:447	CE	446:447	CE	446:447	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	2	36	theme	efficiency	433:442	arg1	"					443:443	"coating efficiency"	424:443	"coating efficiency" (CE)	424:448	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	2	36	theme	efficiency	433:442	arg1	interface					413:421	an arbitrary interface	400:421	an arbitrary interface	400:421	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	2	37	theme	Experiments	382:392	arg1	Design					372:377	the Design	368:377	the Design of Experiments (DOE)	368:398	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	0	38	theme	release	33:39	arg1	spherules					49:57	Ethyl cellulose coated sustained release aspirin spherules	0:57	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.	0:171	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.
34051259	1	39	theme	aspirin	296:302	arg1	spherule					284:291	sustained-release spherule	266:291	sustained-release spherule of aspirin for oral formulations	266:324	This work attempts to resolve one of the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations, tailored to treat COVID-19.
34051259	0	40	dep	spherules	49:57	arg1	led					86:88	led	86:88	led rapid optimization using arbitrary interface; applicable for emergency situations	86:170	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.
34051259	5	41	theme	flow	958:961	arg1	Angle					975:979	Angle	975:979	Angle of repose 29.69 ± 0.780	975:1003	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	5	41	theme	flow	958:961	arg1	properties					963:972	better flow properties	951:972	better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules	951:1088	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	6	42	theme	coated	1161:1166	arg1	spherules					1168:1176	EC coated spherules	1158:1176	EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%	1158:1270	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	1	43	theme	oral	308:311	arg1	formulations					313:324	oral formulations	308:324	oral formulations	308:324	This work attempts to resolve one of the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations, tailored to treat COVID-19.
34051259	9	44	from	approach	1713:1720	arg1	DOE					1725:1727	DOE	1725:1727	DOE	1725:1727	This CE and CPC approach in DOE can be used for delivery system design of other labile drugs similar to aspirin in emergency situations.
34051259	1	45	theme	key	214:216	arg1	issues					218:223	the key issues	210:223	the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations	210:324	This work attempts to resolve one of the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations, tailored to treat COVID-19.
34051259	5	46	theme	1200	839:842	arg1	angle					844:848	a low 1200 angle	833:848	a low 1200 angle	833:848	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	9	47	theme	system	1754:1759	arg1	design					1761:1766	delivery system design	1745:1766	delivery system design of other labile drugs similar to aspirin in emergency situations	1745:1831	This CE and CPC approach in DOE can be used for delivery system design of other labile drugs similar to aspirin in emergency situations.
34051259	1	48	dep	resolve	195:201	arg1	tailored					327:334	tailored	327:334	tailored to treat COVID-19	327:352	This work attempts to resolve one of the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations, tailored to treat COVID-19.
34051259	5	49	theme	±	1024:1024	arg1	%					1030:1030	Carr's index 6.73 ± 2.24%	1006:1030	Carr's index 6.73 ± 2.24%	1006:1030	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	9	50	theme	labile	1777:1782	arg1	drugs					1784:1788	other labile drugs	1771:1788	other labile drugs similar to aspirin in emergency situations	1771:1831	This CE and CPC approach in DOE can be used for delivery system design of other labile drugs similar to aspirin in emergency situations.
34051259	8	51	from	Form-I	1603:1608	arg1	PXRD					1548:1551	PXRD	1548:1551	PXRD	1548:1551	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	8	51	from	Form-I	1603:1608	arg1	diffraction					1535:1545	powder X-ray diffraction	1522:1545	powder X-ray diffraction (PXRD)	1522:1552	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	8	51	from	Form-I	1603:1608	arg1	DSC					1593:1595	DSC	1593:1595	DSC	1593:1595	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	8	51	from	Form-I	1603:1608	arg1	calorimetry					1580:1590	differential scanning calorimetry	1558:1590	differential scanning calorimetry (DSC)	1558:1596	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	3	52	theme	Ethyl	647:651	arg1	EC					664:665	EC	664:665	EC	664:665	Subsequently, the granules containing ASP are converted to spherules and then to Ethyl cellulose (EC) Coated spherules (CS) by a novel bed coating during the rolling (BCDR) process.
34051259	3	52	theme	Ethyl	647:651	arg1	cellulose					653:661	Ethyl cellulose	647:661	Ethyl cellulose (EC) Coated spherules (CS)	647:688	Subsequently, the granules containing ASP are converted to spherules and then to Ethyl cellulose (EC) Coated spherules (CS) by a novel bed coating during the rolling (BCDR) process.
34051259	8	53	theme	differential	1558:1569	arg1	DSC					1593:1595	DSC	1593:1595	DSC	1593:1595	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	8	53	theme	differential	1558:1569	arg1	calorimetry					1580:1590	differential scanning calorimetry	1558:1590	differential scanning calorimetry (DSC)	1558:1596	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	7	54	theme	20	1458:1459	arg1	%					1460:1460	%	1460:1460	%	1460:1460	The results of DOE to experimentally validated results were within 20% deviation.
34051259	6	55	theme	%	1270:1270	arg1	release					1254:1260	a release	1252:1260	a release of 80-91%	1252:1270	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	2	56	theme	drug	547:550	arg1	release					552:558	drug release	547:558	drug release (DR)	547:563	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	2	56	theme	drug	547:550	arg1	DR					561:562	DR	561:562	DR	561:562	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	3	57	contain	containing	593:602	arg2	ASP					604:606	ASP	604:606	ASP	604:606	Subsequently, the granules containing ASP are converted to spherules and then to Ethyl cellulose (EC) Coated spherules (CS) by a novel bed coating during the rolling (BCDR) process.
34051259	3	57	contain	containing	593:602	arg1	granules					584:591	the granules	580:591	the granules containing ASP	580:606	Subsequently, the granules containing ASP are converted to spherules and then to Ethyl cellulose (EC) Coated spherules (CS) by a novel bed coating during the rolling (BCDR) process.
34051259	9	58	theme	emergency	1812:1820	arg1	situations					1822:1831	emergency situations	1812:1831	emergency situations	1812:1831	This CE and CPC approach in DOE can be used for delivery system design of other labile drugs similar to aspirin in emergency situations.
34051259	6	59	theme	certain	1096:1102	arg1	control					1124:1130	certain structure-dependent control	1096:1130	certain structure-dependent control over release	1096:1143	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	2	60	theme	percentage	490:499	arg1	CPC					510:512	CPC	510:512	CPC	510:512	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	2	60	theme	percentage	490:499	arg1	coating					501:507	the cumulative percentage coating	475:507	the cumulative percentage coating (CPC)	475:513	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	0	61	theme	applicable	136:145	arg1	interface					125:133	arbitrary interface; applicable for emergency situations	115:170	arbitrary interface; applicable for emergency situations	115:170	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.
34051259	0	62	theme	emergency	151:159	arg1	situations					161:170	emergency situations	151:170	emergency situations	151:170	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.
34051259	5	63	theme	scanning	911:918	arg1	SEM					941:943	SEM	941:943	SEM	941:943	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	5	63	theme	scanning	911:918	arg1	microscopy					929:938	scanning electron microscopy	911:938	scanning electron microscopy (SEM)	911:944	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	5	64	theme	Ratio	1043:1047	arg1	±					1054:1054	Hausner's Ratio 1.07 ± 0.03	1033:1059	Hausner's Ratio 1.07 ± 0.03	1033:1059	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	3	65	theme	novel	695:699	arg1	coating					705:711	a novel bed coating	693:711	a novel bed coating during the rolling (BCDR) process	693:745	Subsequently, the granules containing ASP are converted to spherules and then to Ethyl cellulose (EC) Coated spherules (CS) by a novel bed coating during the rolling (BCDR) process.
34051259	6	66	theme	EC	1158:1159	arg1	spherules					1168:1176	EC coated spherules	1158:1176	EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%	1158:1270	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	5	67	theme	surface	885:891	arg1	cracks					901:906	smooth surface without cracks	878:906	smooth surface without cracks by scanning electron microscopy (SEM)	878:944	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	5	68	theme	index	1013:1017	arg1	%					1030:1030	Carr's index 6.73 ± 2.24%	1006:1030	Carr's index 6.73 ± 2.24%	1006:1030	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	8	69	theme	drug	1653:1656	arg1	reservoir					1658:1666	the drug reservoir	1649:1666	the drug reservoir	1649:1666	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	7	70	theme	DOE	1406:1408	arg1	results					1395:1401	The results	1391:1401	The results of DOE to experimentally validated results	1391:1444	The results of DOE to experimentally validated results were within 20% deviation.
34051259	4	71	theme	mm	779:780	arg1	mm					792:793	0.35 mm than 0.71 mm	774:793	0.35 mm than 0.71 mm	774:793	Among spherules, one with 0.35 mm than 0.71 mm shows required properties.
34051259	5	72	theme	without	893:899	arg1	cracks					901:906	smooth surface without cracks	878:906	smooth surface without cracks by scanning electron microscopy (SEM)	878:944	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	0	73	theme	rapid	90:94	arg1	optimization					96:107	rapid optimization	90:107	rapid optimization using arbitrary interface; applicable for emergency situations	90:170	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.
34051259	5	74	theme	better	951:956	arg1	Angle					975:979	Angle	975:979	Angle of repose 29.69 ± 0.780	975:1003	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	5	74	theme	better	951:956	arg1	properties					963:972	better flow properties	951:972	better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules	951:1088	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	6	75	dep	attained	1148:1155	arg1	spherules					1168:1176	EC coated spherules	1158:1176	EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%	1158:1270	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	9	76	theme	CE	1702:1703	arg1	approach					1713:1720	This CE and CPC approach	1697:1720	This CE and CPC approach in DOE	1697:1727	This CE and CPC approach in DOE can be used for delivery system design of other labile drugs similar to aspirin in emergency situations.
34051259	0	77	theme	cellulose	6:14	arg1	spherules					49:57	Ethyl cellulose coated sustained release aspirin spherules	0:57	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.	0:171	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.
34051259	6	78	dep	DOE	1333:1335	arg1	%					1346:1346	CE-70.14%and CPC-200%	1338:1358	%	1346:1346	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	6	78	dep	DOE	1333:1335	arg1	%					1358:1358	CE-70.14%and CPC-200%	1338:1358	%	1358:1358	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	6	78	dep	DOE	1333:1335	arg1	%					1372:1372	DR-61.54%	1364:1372	DR-61.54%	1364:1372	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	2	79	theme	arbitrary	403:411	arg1	"					443:443	"coating efficiency"	424:443	"coating efficiency" (CE)	424:448	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	2	79	theme	arbitrary	403:411	arg1	interface					413:421	an arbitrary interface	400:421	an arbitrary interface	400:421	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	9	80	theme	CPC	1709:1711	arg1	approach					1713:1720	This CE and CPC approach	1697:1720	This CE and CPC approach in DOE	1697:1727	This CE and CPC approach in DOE can be used for delivery system design of other labile drugs similar to aspirin in emergency situations.
34051259	0	81	theme	sustained	23:31	arg1	spherules					49:57	Ethyl cellulose coated sustained release aspirin spherules	0:57	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.	0:171	Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations.
34051259	1	82	theme	sustained-release	266:282	arg1	spherule					284:291	sustained-release spherule	266:291	sustained-release spherule of aspirin for oral formulations	266:324	This work attempts to resolve one of the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations, tailored to treat COVID-19.
34051259	6	83	dep	spherules	1168:1176	arg1	shows					1178:1182	shows	1178:1182	shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%	1178:1270	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	8	84	theme	powder	1522:1527	arg1	PXRD					1548:1551	PXRD	1548:1551	PXRD	1548:1551	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	8	84	theme	powder	1522:1527	arg1	diffraction					1535:1545	powder X-ray diffraction	1522:1545	powder X-ray diffraction (PXRD)	1522:1552	The aspirin is changing its crystal structure by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) from Form-I to Form-II showing polymorphism inside the drug reservoir with respect to the process.
34051259	6	85	theme	10	1184:1185	arg1	%					1186:1186	%	1186:1186	%	1186:1186	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	5	86	theme	±	997:997	arg1	Angle					975:979	Angle	975:979	Angle of repose 29.69 ± 0.780	975:1003	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	5	86	theme	±	997:997	arg1	properties					963:972	better flow properties	951:972	better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules	951:1088	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	5	87	theme	Optical	853:859	arg1	Microscopy					861:870	Optical Microscopy	853:870	Optical Microscopy (OM)	853:875	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	5	87	theme	Optical	853:859	arg1	OM					873:874	OM	873:874	OM	873:874	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	2	88	theme	coating	425:431	arg1	CE					446:447	CE	446:447	CE	446:447	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	2	88	theme	coating	425:431	arg1	"					443:443	"coating efficiency"	424:443	"coating efficiency" (CE)	424:448	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	2	88	theme	coating	425:431	arg1	interface					413:421	an arbitrary interface	400:421	an arbitrary interface	400:421	For that, in the Design of Experiments (DOE) an arbitrary interface, "coating efficiency" (CE) is introduced and scaled the cumulative percentage coating (CPC) to get predictable control over drug release (DR).
34051259	1	89	theme	related	225:231	arg1	issues					218:223	the key issues	210:223	the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations	210:324	This work attempts to resolve one of the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations, tailored to treat COVID-19.
34051259	5	90	theme	low	835:837	arg1	angle					844:848	a low 1200 angle	833:848	a low 1200 angle	833:848	The CS has a low 1200 angle by Optical Microscopy (OM), smooth surface without cracks by scanning electron microscopy (SEM), and better flow properties (Angle of repose 29.69 ± 0.780, Carr's index 6.73 ± 2.24%, Hausner's Ratio 1.07 ± 0.03) than granules and spherules.
34051259	9	91	theme	delivery	1745:1752	arg1	system					1754:1759	delivery system	1745:1759	delivery system design of other labile drugs similar to aspirin in emergency situations	1745:1831	This CE and CPC approach in DOE can be used for delivery system design of other labile drugs similar to aspirin in emergency situations.
34051259	6	92	theme	uncoated	1225:1232	arg1	spherules					1234:1242	uncoated spherules	1225:1242	uncoated spherules showing a release of 80-91%	1225:1270	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	1	93	theme	issues	218:223	arg1	one					203:205	one	203:205	one	203:205	This work attempts to resolve one of the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations, tailored to treat COVID-19.
34051259	1	93	theme	issues	218:223	arg1	issues					218:223	the key issues	210:223	the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations	210:324	This work attempts to resolve one of the key issues related to the design and development of sustained-release spherule of aspirin for oral formulations, tailored to treat COVID-19.
34051259	6	94	theme	burst	1201:1205	arg1	BR					1216:1217	BR	1216:1217	BR	1216:1217	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34051259	6	94	theme	burst	1201:1205	arg1	release					1207:1213	burst release	1201:1213	burst release (BR)	1201:1218	Once certain structure-dependent control over release is attained (EC coated spherules shows 10% reduction in burst release (BR) than uncoated spherules showing a release of 80-91%) the predictability is achieved and Design of space (DOS) by DOE (CE-70.14%and CPC-200% and DR-61.54%) is established.
34294314	0	0	theme	polysaccharide	95:108	arg1	activity					74:81	macrophage immunomodulatory activity	46:81	macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch	46:137	Structural characterization and mechanisms of macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch.
34294314	5	1	theme	molecular	1154:1162	arg1	basis					1164:1168	the molecular basis	1150:1168	the molecular basis for the potential use of CMDP-4b as a natural immunostimulant	1150:1230	Our study provides the molecular basis for the potential use of CMDP-4b as a natural immunostimulant.
34294314	2	2	theme	O-3	644:646	arg1	position					648:655	the O-3 position	640:655	the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→	640:686	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	0	3	theme	pectic	88:93	arg1	polysaccharide					95:108	a pectic polysaccharide	86:108	a pectic polysaccharide from Cucurbita moschata Duch	86:137	Structural characterization and mechanisms of macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch.
34294314	2	4	theme	1→	685:686	arg1	position					648:655	the O-3 position	640:655	the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→	640:686	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	3	5	dep	cytokines	785:793	arg1	TNF-α					808:812	TNF-α	808:812	TNF-α	808:812	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	3	5	dep	cytokines	785:793	arg1	IL-6					819:822	IL-6	819:822	IL-6	819:822	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	3	5	dep	cytokines	785:793	arg1	IL-1β					801:805	IL-1β	801:805	IL-1β	801:805	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	3	5	dep	cytokines	785:793	arg1	cytokines					785:793	cytokines	785:793	cytokines (i.e. IL-1β, TNF-α, and IL-6)	785:823	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	3	6	theme	macrophages	882:892	arg1	activities					868:877	pinocytic and phagocytic activities	843:877	pinocytic and phagocytic activities of macrophages	843:892	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	4	7	theme	toll-like	966:974	arg1	receptor					976:983	toll-like receptor 4	966:985	toll-like receptor 4	966:985	Moreover, toll-like receptor 4 and complement receptor 3 may play a critical role in CMDP-4b-induced macrophage activation through the NF-κB and the MAPKs signaling pathways.
34294314	0	8	from	activity	74:81	arg1	Duch					134:137	Duch	134:137	Duch	134:137	Structural characterization and mechanisms of macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch.
34294314	4	9	theme	CMDP-4b-induced	1041:1055	arg1	activation					1068:1077	CMDP-4b-induced macrophage activation	1041:1077	CMDP-4b-induced macrophage activation	1041:1077	Moreover, toll-like receptor 4 and complement receptor 3 may play a critical role in CMDP-4b-induced macrophage activation through the NF-κB and the MAPKs signaling pathways.
34294314	2	10	theme	-α-D-GalpA-6-OMe-	667:683	arg1	1→					685:686	the →4)-α-D-GalpA-6-OMe-(1→	660:686	the →4)-α-D-GalpA-6-OMe-(1→	660:686	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	1	11	theme	column	276:281	arg1	chromatography					283:296	column chromatography	276:296	column chromatography	276:296	A pectic polysaccharide (named CMDP-4b) with a molecular weight of 31.97 kDa was extracted from Cucurbita moschata Duch and purified by column chromatography.
34294314	2	12	theme	→4	664:665	arg1	1→					685:686	the →4)-α-D-GalpA-6-OMe-(1→	660:686	the →4)-α-D-GalpA-6-OMe-(1→	660:686	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	2	13	theme	two-dimensional	397:411	arg1	spectroscopy					440:451	one- and two-dimensional nuclear magnetic resonance spectroscopy	388:451	one- and two-dimensional nuclear magnetic resonance spectroscopy	388:451	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	2	13	theme	two-dimensional	397:411	arg1	methylation					315:325	methylation	315:325	methylation	315:325	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	2	14	theme	magnetic	421:428	arg1	spectroscopy					440:451	one- and two-dimensional nuclear magnetic resonance spectroscopy	388:451	one- and two-dimensional nuclear magnetic resonance spectroscopy	388:451	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	2	14	theme	magnetic	421:428	arg1	methylation					315:325	methylation	315:325	methylation	315:325	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	2	15	theme	homogalacturonan	537:552	arg1	backbone					554:561	an α-1,4-linked homogalacturonan backbone	521:561	an α-1,4-linked homogalacturonan backbone	521:561	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	3	16	dep	IL-1β	801:805	arg1	i.e.					796:799	i.e.	796:799	i.e.	796:799	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	1	17	with	polysaccharide	149:162	arg1	weight					197:202	a molecular weight	185:202	a molecular weight of 31.97 kDa	185:215	A pectic polysaccharide (named CMDP-4b) with a molecular weight of 31.97 kDa was extracted from Cucurbita moschata Duch and purified by column chromatography.
34294314	2	18	theme	nuclear	413:419	arg1	spectroscopy					440:451	one- and two-dimensional nuclear magnetic resonance spectroscopy	388:451	one- and two-dimensional nuclear magnetic resonance spectroscopy	388:451	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	2	18	theme	nuclear	413:419	arg1	methylation					315:325	methylation	315:325	methylation	315:325	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	2	19	theme	CMDP-4b	480:486	arg1	structure					467:475	the structure	463:475	the structure of CMDP-4b	463:486	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	5	20	theme	natural	1208:1214	arg1	immunostimulant					1216:1230	a natural immunostimulant	1206:1230	a natural immunostimulant	1206:1230	Our study provides the molecular basis for the potential use of CMDP-4b as a natural immunostimulant.
34294314	2	21	dep	infrared	346:353	arg1	analyses					453:460	analyses	453:460	analyses	453:460	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	1	22	theme	molecular	187:195	arg1	weight					197:202	a molecular weight	185:202	a molecular weight of 31.97 kDa	185:215	A pectic polysaccharide (named CMDP-4b) with a molecular weight of 31.97 kDa was extracted from Cucurbita moschata Duch and purified by column chromatography.
34294314	0	23	theme	Structural	0:9	arg1	characterization					11:26	Structural characterization	0:26	Structural characterization	0:26	Structural characterization and mechanisms of macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch.
34294314	5	24	theme	CMDP-4b	1195:1201	arg1	use					1188:1190	the potential use	1174:1190	the potential use of CMDP-4b as a natural immunostimulant	1174:1230	Our study provides the molecular basis for the potential use of CMDP-4b as a natural immunostimulant.
34294314	3	25	theme	cytokines	785:793	arg1	secretion					754:762	the secretion	750:762	the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6)	750:823	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	2	26	dep	acetylated	583:592	arg1	methyl-esterified					605:621	methyl-esterified	605:621	methyl-esterified	605:621	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	4	27	theme	macrophage	1057:1066	arg1	activation					1068:1077	CMDP-4b-induced macrophage activation	1041:1077	CMDP-4b-induced macrophage activation	1041:1077	Moreover, toll-like receptor 4 and complement receptor 3 may play a critical role in CMDP-4b-induced macrophage activation through the NF-κB and the MAPKs signaling pathways.
34294314	3	28	theme	nitrous	767:773	arg1	oxide					775:779	nitrous oxide	767:779	nitrous oxide	767:779	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	1	29	theme	31.97 kDa	207:215	arg1	weight					197:202	a molecular weight	185:202	a molecular weight of 31.97 kDa	185:215	A pectic polysaccharide (named CMDP-4b) with a molecular weight of 31.97 kDa was extracted from Cucurbita moschata Duch and purified by column chromatography.
34294314	0	30	theme	macrophage	46:55	arg1	activity					74:81	macrophage immunomodulatory activity	46:81	macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch	46:137	Structural characterization and mechanisms of macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch.
34294314	3	31	theme	oxide	775:779	arg1	secretion					754:762	the secretion	750:762	the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6)	750:823	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	4	32	theme	MAPKs	1105:1109	arg1	pathways					1121:1128	the MAPKs signaling pathways	1101:1128	the MAPKs signaling pathways	1101:1128	Moreover, toll-like receptor 4 and complement receptor 3 may play a critical role in CMDP-4b-induced macrophage activation through the NF-κB and the MAPKs signaling pathways.
34294314	4	33	theme	critical	1024:1031	arg1	role					1033:1036	a critical role	1022:1036	a critical role	1022:1036	Moreover, toll-like receptor 4 and complement receptor 3 may play a critical role in CMDP-4b-induced macrophage activation through the NF-κB and the MAPKs signaling pathways.
34294314	3	34	theme	immunomodulatory	929:944	arg1	activity					946:953	immunomodulatory activity	929:953	immunomodulatory activity	929:953	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	2	35	theme	resonance	430:438	arg1	spectroscopy					440:451	one- and two-dimensional nuclear magnetic resonance spectroscopy	388:451	one- and two-dimensional nuclear magnetic resonance spectroscopy	388:451	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	2	35	theme	resonance	430:438	arg1	methylation					315:325	methylation	315:325	methylation	315:325	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	0	36	theme	activity	74:81	arg1	mechanisms					32:41	mechanisms	32:41	mechanisms	32:41	Structural characterization and mechanisms of macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch.
34294314	0	36	theme	activity	74:81	arg1	characterization					11:26	Structural characterization	0:26	Structural characterization	0:26	Structural characterization and mechanisms of macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch.
34294314	5	37	theme	potential	1178:1186	arg1	use					1188:1190	the potential use	1174:1190	the potential use of CMDP-4b as a natural immunostimulant	1174:1230	Our study provides the molecular basis for the potential use of CMDP-4b as a natural immunostimulant.
34294314	2	38	theme	monosaccharide	356:369	arg1	methylation					315:325	methylation	315:325	methylation	315:325	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	2	38	theme	monosaccharide	356:369	arg1	composition					371:381	monosaccharide composition	356:381	monosaccharide composition	356:381	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	0	39	theme	immunomodulatory	57:72	arg1	activity					74:81	macrophage immunomodulatory activity	46:81	macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch	46:137	Structural characterization and mechanisms of macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch.
34294314	0	40	from	Duch	134:137	arg1	polysaccharide					95:108	a pectic polysaccharide	86:108	a pectic polysaccharide from Cucurbita moschata Duch	86:137	Structural characterization and mechanisms of macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch.
34294314	0	40	from	Duch	134:137	arg1	activity					74:81	macrophage immunomodulatory activity	46:81	macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch	46:137	Structural characterization and mechanisms of macrophage immunomodulatory activity of a pectic polysaccharide from Cucurbita moschata Duch.
34294314	2	41	link	α-1,4-linked	524:535	arg1	backbone					554:561	an α-1,4-linked homogalacturonan backbone	521:561	an α-1,4-linked homogalacturonan backbone	521:561	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	3	42	theme	phagocytic	857:866	arg1	activities					868:877	pinocytic and phagocytic activities	843:877	pinocytic and phagocytic activities of macrophages	843:892	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	1	43	theme	pectic	142:147	arg1	polysaccharide					149:162	A pectic polysaccharide	140:162	A pectic polysaccharide (named CMDP-4b) with a molecular weight of 31.97 kDa	140:215	A pectic polysaccharide (named CMDP-4b) with a molecular weight of 31.97 kDa was extracted from Cucurbita moschata Duch and purified by column chromatography.
34294314	1	43	theme	pectic	142:147	arg1	CMDP-4b					171:177	named CMDP-4b	165:177	named CMDP-4b	165:177	A pectic polysaccharide (named CMDP-4b) with a molecular weight of 31.97 kDa was extracted from Cucurbita moschata Duch and purified by column chromatography.
34294314	3	44	contain	possessed	919:927	arg1	CMDP-4b					911:917	CMDP-4b	911:917	CMDP-4b	911:917	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	3	44	contain	possessed	919:927	arg2	activity					946:953	immunomodulatory activity	929:953	immunomodulatory activity	929:953	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	2	45	dep	methylation	315:325	arg1	the					302:304	the	302:304	the	302:304	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	2	45	dep	methylation	315:325	arg1	basis					306:310	basis	306:310	basis	306:310	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	3	46	theme	pinocytic	843:851	arg1	activities					868:877	pinocytic and phagocytic activities	843:877	pinocytic and phagocytic activities of macrophages	843:892	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	2	47	theme	α-1,4-linked	524:535	arg1	backbone					554:561	an α-1,4-linked homogalacturonan backbone	521:561	an α-1,4-linked homogalacturonan backbone	521:561	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	3	48	theme	Immunomodulatory	689:704	arg1	assays					706:711	Immunomodulatory assays	689:711	Immunomodulatory assays	689:711	Immunomodulatory assays showed that CMDP-4b not only induced the secretion of nitrous oxide and cytokines (i.e. IL-1β, TNF-α, and IL-6) but also promoted pinocytic and phagocytic activities of macrophages, suggesting that CMDP-4b possessed immunomodulatory activity.
34294314	2	49	theme	one-	388:391	arg1	spectroscopy					440:451	one- and two-dimensional nuclear magnetic resonance spectroscopy	388:451	one- and two-dimensional nuclear magnetic resonance spectroscopy	388:451	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	2	49	theme	one-	388:391	arg1	methylation					315:325	methylation	315:325	methylation	315:325	On the basis of methylation, Fourier-transform infrared, monosaccharide composition, and one- and two-dimensional nuclear magnetic resonance spectroscopy analyses, the structure of CMDP-4b was determined to be composed of an α-1,4-linked homogalacturonan backbone, which was slightly acetylated and highly methyl-esterified, and branched at the O-3 position of the →4)-α-D-GalpA-6-OMe-(1→.
34294314	4	50	theme	signaling	1111:1119	arg1	pathways					1121:1128	the MAPKs signaling pathways	1101:1128	the MAPKs signaling pathways	1101:1128	Moreover, toll-like receptor 4 and complement receptor 3 may play a critical role in CMDP-4b-induced macrophage activation through the NF-κB and the MAPKs signaling pathways.
34294314	4	51	theme	complement	991:1000	arg1	receptor					1002:1009	complement receptor 3	991:1011	complement receptor 3	991:1011	Moreover, toll-like receptor 4 and complement receptor 3 may play a critical role in CMDP-4b-induced macrophage activation through the NF-κB and the MAPKs signaling pathways.
34294314	1	52	theme	named	165:169	arg1	polysaccharide					149:162	A pectic polysaccharide	140:162	A pectic polysaccharide (named CMDP-4b) with a molecular weight of 31.97 kDa	140:215	A pectic polysaccharide (named CMDP-4b) with a molecular weight of 31.97 kDa was extracted from Cucurbita moschata Duch and purified by column chromatography.
34294314	1	52	theme	named	165:169	arg1	CMDP-4b					171:177	named CMDP-4b	165:177	named CMDP-4b	165:177	A pectic polysaccharide (named CMDP-4b) with a molecular weight of 31.97 kDa was extracted from Cucurbita moschata Duch and purified by column chromatography.
32203919	5	0	theme	ultrasonic	731:740	arg1	power					742:746	ultrasonic power	731:746	ultrasonic power	731:746	The peroxide value of soybean oil was significantly reduced from 16.99 ± 0.78 meq/kg to 2.23 ± 0.09 meq/kg with the increase of ultrasonic power.
32203919	7	1	theme	main	956:959	arg1	forces					961:966	the main forces	952:966	the main forces between RPH and CS	952:985	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	7	1	theme	main	956:959	arg1	bonds					906:910	hydrogen bonds	897:910	hydrogen bonds	897:910	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	7	1	theme	main	956:959	arg1	interactions					925:936	covalent interactions	916:936	covalent interactions	916:936	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	5	2	theme	power	742:746	arg1	increase					719:726	the increase	715:726	the increase of ultrasonic power	715:746	The peroxide value of soybean oil was significantly reduced from 16.99 ± 0.78 meq/kg to 2.23 ± 0.09 meq/kg with the increase of ultrasonic power.
32203919	3	3	theme	film-forming	466:477	arg1	solutions					479:487	film-forming solutions	466:487	film-forming solutions	466:487	Results showed that ultrasound treatment decreased the particle size and the viscosity of film-forming solutions.
32203919	4	4	theme	films	536:540	arg1	break					517:521	break	517:521	break of composite films	517:540	The value of elongation at break of composite films was increased by 125% at 400 W compared with untreated film.
32203919	0	5	theme	protein	81:87	arg1	hydrolysates					89:100	rice protein hydrolysates	76:100	rice protein hydrolysates	76:100	Effect of ultrasonic power on properties of edible composite films based on rice protein hydrolysates and chitosan.
32203919	0	6	from	Effect	0:5	arg1	properties					30:39	properties	30:39	properties of edible composite films	30:65	Effect of ultrasonic power on properties of edible composite films based on rice protein hydrolysates and chitosan.
32203919	5	7	theme	peroxide	607:614	arg1	value					616:620	The peroxide value	603:620	The peroxide value of soybean oil	603:635	The peroxide value of soybean oil was significantly reduced from 16.99 ± 0.78 meq/kg to 2.23 ± 0.09 meq/kg with the increase of ultrasonic power.
32203919	0	8	theme	rice	76:79	arg1	hydrolysates					89:100	rice protein hydrolysates	76:100	rice protein hydrolysates	76:100	Effect of ultrasonic power on properties of edible composite films based on rice protein hydrolysates and chitosan.
32203919	7	9	theme	Fourier	1080:1086	arg1	analyses					1068:1075	analyses	1068:1075	analyses of Fourier transform infrared spectroscopy and X-ray diffraction	1068:1140	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	7	10	theme	covalent	916:923	arg1	forces					961:966	the main forces	952:966	the main forces between RPH and CS	952:985	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	7	10	theme	covalent	916:923	arg1	interactions					925:936	covalent interactions	916:936	covalent interactions	916:936	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	7	10	theme	covalent	916:923	arg1	bonds					906:910	hydrogen bonds	897:910	hydrogen bonds	897:910	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	6	11	theme	200 W	855:859	arg1	films					822:826	the films	818:826	the films at ultrasound treatment of 200 W	818:859	Ultrasound treatment was efficient in keeping smooth on surface, and the films at ultrasound treatment of 200 W had better compatibility.
32203919	8	12	theme	composite	1243:1251	arg1	films					1253:1257	edible composite films	1236:1257	edible composite films	1236:1257	These results suggested that ultrasound was an effective method to improve the properties of edible composite films.
32203919	7	13	dep	transform	1088:1096	arg1	infrared					1098:1105	infrared	1098:1105	transform infrared spectroscopy and X-ray diffraction	1088:1140	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	3	14	theme	ultrasound	396:405	arg1	treatment					407:415	ultrasound treatment	396:415	ultrasound treatment	396:415	Results showed that ultrasound treatment decreased the particle size and the viscosity of film-forming solutions.
32203919	4	15	from	400 W	567:571	arg1	%					562:562	125%	559:562	125% at 400 W	559:571	The value of elongation at break of composite films was increased by 125% at 400 W compared with untreated film.
32203919	2	16	theme	composite	336:344	arg1	films					346:350	rice protein hydrolysates/chitosan (RPH/CS) edible composite films	285:350	rice protein hydrolysates/chitosan (RPH/CS) edible composite films	285:350	Hence, we used chitosan (CS) as a modifier and developed rice protein hydrolysates/chitosan (RPH/CS) edible composite films by means of ultrasound.
32203919	7	17	dep	Fourier	1080:1086	arg1	transform					1088:1096	transform	1088:1096	transform infrared spectroscopy and X-ray diffraction	1088:1140	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	6	18	theme	Ultrasound	749:758	arg1	treatment					760:768	Ultrasound treatment	749:768	Ultrasound treatment	749:768	Ultrasound treatment was efficient in keeping smooth on surface, and the films at ultrasound treatment of 200 W had better compatibility.
32203919	2	19	theme	edible	329:334	arg1	films					346:350	rice protein hydrolysates/chitosan (RPH/CS) edible composite films	285:350	rice protein hydrolysates/chitosan (RPH/CS) edible composite films	285:350	Hence, we used chitosan (CS) as a modifier and developed rice protein hydrolysates/chitosan (RPH/CS) edible composite films by means of ultrasound.
32203919	0	20	theme	power	21:25	arg1	Effect					0:5	Effect	0:5	Effect of ultrasonic power on properties of edible composite films	0:65	Effect of ultrasonic power on properties of edible composite films based on rice protein hydrolysates and chitosan.
32203919	7	21	theme	hydrogen	897:904	arg1	bonds					906:910	hydrogen bonds	897:910	hydrogen bonds	897:910	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	7	21	theme	hydrogen	897:904	arg1	forces					961:966	the main forces	952:966	the main forces between RPH and CS	952:985	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	7	21	theme	hydrogen	897:904	arg1	interactions					925:936	covalent interactions	916:936	covalent interactions	916:936	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	4	22	from	value	494:498	arg1	break					517:521	break	517:521	break of composite films	517:540	The value of elongation at break of composite films was increased by 125% at 400 W compared with untreated film.
32203919	1	23	theme	formation	170:178	arg1	incapable					152:160	incapable	152:160	incapable	152:160	Rice protein hydrolysates (RPH) are incapable of film formation by self-crosslinking due to low molecular mass.
32203919	0	24	theme	ultrasonic	10:19	arg1	power					21:25	ultrasonic power	10:25	ultrasonic power	10:25	Effect of ultrasonic power on properties of edible composite films based on rice protein hydrolysates and chitosan.
32203919	4	25	theme	composite	526:534	arg1	films					536:540	composite films	526:540	composite films	526:540	The value of elongation at break of composite films was increased by 125% at 400 W compared with untreated film.
32203919	6	26	theme	ultrasound	831:840	arg1	treatment					842:850	ultrasound treatment	831:850	ultrasound treatment	831:850	Ultrasound treatment was efficient in keeping smooth on surface, and the films at ultrasound treatment of 200 W had better compatibility.
32203919	3	27	theme	particle	431:438	arg1	size					440:443	the particle size	427:443	the particle size	427:443	Results showed that ultrasound treatment decreased the particle size and the viscosity of film-forming solutions.
32203919	7	28	theme	X-ray	1124:1128	arg1	diffraction					1130:1140	X-ray diffraction	1124:1140	X-ray diffraction	1124:1140	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	4	29	dep	increased	546:554	arg1	compared					573:580	compared	573:580	compared with untreated film	573:600	The value of elongation at break of composite films was increased by 125% at 400 W compared with untreated film.
32203919	1	30	theme	film	165:168	arg1	formation					170:178	film formation	165:178	film formation	165:178	Rice protein hydrolysates (RPH) are incapable of film formation by self-crosslinking due to low molecular mass.
32203919	8	31	theme	effective	1190:1198	arg1	method					1200:1205	an effective method	1187:1205	an effective method to improve the properties of edible composite films	1187:1257	These results suggested that ultrasound was an effective method to improve the properties of edible composite films.
32203919	8	31	theme	effective	1190:1198	arg1	ultrasound					1172:1181	ultrasound	1172:1181	ultrasound	1172:1181	These results suggested that ultrasound was an effective method to improve the properties of edible composite films.
32203919	7	32	theme	ultrasound	1027:1036	arg1	treatment					1038:1046	ultrasound treatment	1027:1046	ultrasound treatment	1027:1046	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	4	33	from	break	517:521	arg1	elongation					503:512	elongation	503:512	elongation at break of composite films	503:540	The value of elongation at break of composite films was increased by 125% at 400 W compared with untreated film.
32203919	4	33	from	break	517:521	arg1	value					494:498	The value	490:498	The value of elongation at break of composite films	490:540	The value of elongation at break of composite films was increased by 125% at 400 W compared with untreated film.
32203919	4	34	theme	untreated	587:595	arg1	film					597:600	untreated film	587:600	untreated film	587:600	The value of elongation at break of composite films was increased by 125% at 400 W compared with untreated film.
32203919	0	35	theme	edible	44:49	arg1	films					61:65	edible composite films	44:65	edible composite films	44:65	Effect of ultrasonic power on properties of edible composite films based on rice protein hydrolysates and chitosan.
32203919	7	36	theme	film	1006:1009	arg1	formation					1011:1019	film formation	1006:1019	film formation	1006:1019	Moreover, hydrogen bonds and covalent interactions were probably the main forces between RPH and CS and contributed to film formation under ultrasound treatment, which supported by analyses of Fourier transform infrared spectroscopy and X-ray diffraction.
32203919	6	37	theme	better	865:870	arg1	compatibility					872:884	better compatibility	865:884	better compatibility	865:884	Ultrasound treatment was efficient in keeping smooth on surface, and the films at ultrasound treatment of 200 W had better compatibility.
32203919	4	38	theme	elongation	503:512	arg1	value					494:498	The value	490:498	The value of elongation at break of composite films	490:540	The value of elongation at break of composite films was increased by 125% at 400 W compared with untreated film.
32203919	5	39	theme	soybean	625:631	arg1	oil					633:635	soybean oil	625:635	soybean oil	625:635	The peroxide value of soybean oil was significantly reduced from 16.99 ± 0.78 meq/kg to 2.23 ± 0.09 meq/kg with the increase of ultrasonic power.
32203919	5	40	theme	oil	633:635	arg1	value					616:620	The peroxide value	603:620	The peroxide value of soybean oil	603:635	The peroxide value of soybean oil was significantly reduced from 16.99 ± 0.78 meq/kg to 2.23 ± 0.09 meq/kg with the increase of ultrasonic power.
32203919	8	41	theme	edible	1236:1241	arg1	films					1253:1257	edible composite films	1236:1257	edible composite films	1236:1257	These results suggested that ultrasound was an effective method to improve the properties of edible composite films.
32203919	1	42	theme	Rice	116:119	arg1	RPH					143:145	RPH	143:145	RPH	143:145	Rice protein hydrolysates (RPH) are incapable of film formation by self-crosslinking due to low molecular mass.
32203919	1	42	theme	Rice	116:119	arg1	hydrolysates					129:140	Rice protein hydrolysates	116:140	Rice protein hydrolysates (RPH)	116:146	Rice protein hydrolysates (RPH) are incapable of film formation by self-crosslinking due to low molecular mass.
32203919	1	43	theme	protein	121:127	arg1	RPH					143:145	RPH	143:145	RPH	143:145	Rice protein hydrolysates (RPH) are incapable of film formation by self-crosslinking due to low molecular mass.
32203919	1	43	theme	protein	121:127	arg1	hydrolysates					129:140	Rice protein hydrolysates	116:140	Rice protein hydrolysates (RPH)	116:146	Rice protein hydrolysates (RPH) are incapable of film formation by self-crosslinking due to low molecular mass.
32203919	1	44	theme	low	208:210	arg1	mass					222:225	low molecular mass	208:225	low molecular mass	208:225	Rice protein hydrolysates (RPH) are incapable of film formation by self-crosslinking due to low molecular mass.
32203919	0	45	theme	films	61:65	arg1	properties					30:39	properties	30:39	properties of edible composite films	30:65	Effect of ultrasonic power on properties of edible composite films based on rice protein hydrolysates and chitosan.
32203919	6	46	contain	had	861:863	arg1	films					822:826	the films	818:826	the films at ultrasound treatment of 200 W	818:859	Ultrasound treatment was efficient in keeping smooth on surface, and the films at ultrasound treatment of 200 W had better compatibility.
32203919	6	46	contain	had	861:863	arg2	compatibility					872:884	better compatibility	865:884	better compatibility	865:884	Ultrasound treatment was efficient in keeping smooth on surface, and the films at ultrasound treatment of 200 W had better compatibility.
32203919	8	47	theme	films	1253:1257	arg1	properties					1222:1231	the properties	1218:1231	the properties of edible composite films	1218:1257	These results suggested that ultrasound was an effective method to improve the properties of edible composite films.
32203919	3	48	theme	solutions	479:487	arg1	size					440:443	the particle size	427:443	the particle size	427:443	Results showed that ultrasound treatment decreased the particle size and the viscosity of film-forming solutions.
32203919	3	48	theme	solutions	479:487	arg1	viscosity					453:461	the viscosity	449:461	the viscosity of film-forming solutions	449:487	Results showed that ultrasound treatment decreased the particle size and the viscosity of film-forming solutions.
32203919	1	49	theme	molecular	212:220	arg1	mass					222:225	low molecular mass	208:225	low molecular mass	208:225	Rice protein hydrolysates (RPH) are incapable of film formation by self-crosslinking due to low molecular mass.
32203919	0	50	theme	composite	51:59	arg1	films					61:65	edible composite films	44:65	edible composite films	44:65	Effect of ultrasonic power on properties of edible composite films based on rice protein hydrolysates and chitosan.
32203919	2	51	used	used	238:241	arg2	we					235:236	we	235:236	we	235:236	Hence, we used chitosan (CS) as a modifier and developed rice protein hydrolysates/chitosan (RPH/CS) edible composite films by means of ultrasound.
32203919	6	52	from	treatment	842:850	arg1	films					822:826	the films	818:826	the films at ultrasound treatment of 200 W	818:859	Ultrasound treatment was efficient in keeping smooth on surface, and the films at ultrasound treatment of 200 W had better compatibility.
32764929	6	0	link	FITC-dextran-derived	842:861	arg1	images					882:887	FITC-dextran-derived green fluorescence images	842:887	FITC-dextran-derived green fluorescence images	842:887	During the drug release, FITC-dextran-derived green fluorescence images were captured using fluorescent inverted microscope.
32764929	12	1	with	shrank	1762:1767	arg1	duration					1704:1711	an increasing duration	1690:1711	an increasing duration of NIR irradiation	1690:1730	With an increasing duration of NIR irradiation, the microparticles gradually shrank, the reflection peak shifted toward blue and the structural color changed from red to orange, yellow, green, cyan, and blue successively.
32764929	5	2	theme	FITC-dextran-derived	710:729	arg1	images					750:755	FITC-dextran-derived green fluorescence images	710:755	FITC-dextran-derived green fluorescence images	710:755	The morphology of microparticle was observed under scanning electron microscopy, and FITC-dextran-derived green fluorescence images were determined using a confocal laser scanning microscope.
32764929	12	3	theme	irradiation	1720:1730	arg1	duration					1704:1711	an increasing duration	1690:1711	an increasing duration of NIR irradiation	1690:1730	With an increasing duration of NIR irradiation, the microparticles gradually shrank, the reflection peak shifted toward blue and the structural color changed from red to orange, yellow, green, cyan, and blue successively.
32764929	10	4	theme	%	1462:1462	arg1	alginate					1471:1478	0.2 wt% sodium alginate	1456:1478	0.2 wt% sodium alginate	1456:1478	The FITC-dextran was uniformly encapsulated in the particles by using 0.2 wt% sodium alginate.
32764929	2	5	theme	limited	267:273	arg1	stimuli					275:281	limited stimuli	267:281	limited stimuli	267:281	However, some problems remain to be solved, such as limited stimuli, visual-monitoring.
32764929	5	6	theme	electron	685:692	arg1	microscopy					694:703	scanning electron microscopy	676:703	scanning electron microscopy	676:703	The morphology of microparticle was observed under scanning electron microscopy, and FITC-dextran-derived green fluorescence images were determined using a confocal laser scanning microscope.
32764929	6	7	theme	FITC-dextran-derived	842:861	arg1	images					882:887	FITC-dextran-derived green fluorescence images	842:887	FITC-dextran-derived green fluorescence images	842:887	During the drug release, FITC-dextran-derived green fluorescence images were captured using fluorescent inverted microscope.
32764929	14	8	theme	great	2039:2043	arg1	potential					2045:2053	great potential	2039:2053	great potential in drug delivery systems	2039:2078	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	9	9	theme	GO	1264:1265	arg1	GO					1264:1265	GO	1264:1265	GO	1264:1265	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	9	theme	GO	1264:1265	arg1	4mg/mL					1254:1259	4mg/mL	1254:1259	4mg/mL of GO	1254:1265	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	9	theme	GO	1264:1265	arg1	v/v					1236:1238	v/v	1236:1238	v/v	1236:1238	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	9	theme	GO	1264:1265	arg1	PEGDA					1244:1248	PEGDA	1244:1248	PEGDA	1244:1248	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	9	theme	GO	1264:1265	arg1	%					1233:1233	A fixed concentration 8%	1210:1233	A fixed concentration 8% (v/v) of PEGDA	1210:1248	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	5	10	theme	confocal	781:788	arg1	microscope					805:814	a confocal laser scanning microscope	779:814	a confocal laser scanning microscope	779:814	The morphology of microparticle was observed under scanning electron microscopy, and FITC-dextran-derived green fluorescence images were determined using a confocal laser scanning microscope.
32764929	4	11	theme	GO/pNIPAM/PEGDA	477:491	arg1	scaffolds					525:533	GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds	477:533	GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds	477:533	MATERIALS AND METHODS Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template.
32764929	5	12	theme	fluorescence	737:748	arg1	images					750:755	FITC-dextran-derived green fluorescence images	710:755	FITC-dextran-derived green fluorescence images	710:755	The morphology of microparticle was observed under scanning electron microscopy, and FITC-dextran-derived green fluorescence images were determined using a confocal laser scanning microscope.
32764929	3	13	theme	multicolor	333:342	arg1	DDSs					344:347	an intelligent multicolor DDSs	318:347	an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes	318:426	AIM To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.
32764929	7	14	from	change	1033:1038	arg1	values					1064:1069	optical density (OD) values	1043:1069	optical density (OD) values	1043:1069	The relationship between the power of NIR and the drug release rate was obtained using the change in optical density (OD) values.
32764929	11	15	theme	photothermal	1521:1532	arg1	response					1534:1541	the photothermal response	1517:1541	the photothermal response	1517:1541	The microcarriers shrank because of the photothermal response and the intrinsic fluorescence intensity of FITC-dextran in the microparticles gradually decreased at the same time, indicating drug release.
32764929	0	16	theme	Color	83:87	arg1	Changes					89:95	Visual Stimuli-Responsive Structural Color Changes	46:95	Visual Stimuli-Responsive Structural Color Changes	46:95	Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes.
32764929	1	17	theme	demonstrated	160:171	arg1	value					173:177	a demonstrated value	158:177	a demonstrated value for drug discovery and development	158:212	BACKGROUND Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development.
32764929	13	18	theme	release	1916:1922	arg1	quantity					1924:1931	The drug release quantity	1907:1931	The drug release quantity	1907:1931	The drug release quantity can be predicted by the structural color of microparticles.
32764929	7	19	theme	optical	1043:1049	arg1	OD					1060:1061	OD	1060:1061	OD	1060:1061	The relationship between the power of NIR and the drug release rate was obtained using the change in optical density (OD) values.
32764929	7	19	theme	optical	1043:1049	arg1	density					1051:1057	optical density	1043:1057	optical density (OD) values	1043:1069	The relationship between the power of NIR and the drug release rate was obtained using the change in optical density (OD) values.
32764929	9	20	theme	PEGDA	1244:1248	arg1	GO					1264:1265	GO	1264:1265	GO	1264:1265	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	20	theme	PEGDA	1244:1248	arg1	4mg/mL					1254:1259	4mg/mL	1254:1259	4mg/mL of GO	1254:1265	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	20	theme	PEGDA	1244:1248	arg1	v/v					1236:1238	v/v	1236:1238	v/v	1236:1238	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	20	theme	PEGDA	1244:1248	arg1	PEGDA					1244:1248	PEGDA	1244:1248	PEGDA	1244:1248	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	20	theme	PEGDA	1244:1248	arg1	%					1233:1233	A fixed concentration 8%	1210:1233	A fixed concentration 8% (v/v) of PEGDA	1210:1248	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	3	21	theme	near-infrared	359:371	arg1	NIR					374:376	NIR	374:376	NIR	374:376	AIM To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.
32764929	3	21	theme	near-infrared	359:371	arg1	release					390:396	near-infrared (NIR) controlled release	359:396	near-infrared (NIR) controlled release	359:396	AIM To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.
32764929	14	22	theme	good	2157:2160	arg1	responsivity					2170:2181	the good stimuli responsivity	2153:2181	the good stimuli responsivity	2153:2181	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	11	23	theme	intrinsic	1551:1559	arg1	intensity					1574:1582	the intrinsic fluorescence intensity	1547:1582	the intrinsic fluorescence intensity of FITC-dextran in the microparticles	1547:1620	The microcarriers shrank because of the photothermal response and the intrinsic fluorescence intensity of FITC-dextran in the microparticles gradually decreased at the same time, indicating drug release.
32764929	5	24	theme	scanning	796:803	arg1	microscope					805:814	a confocal laser scanning microscope	779:814	a confocal laser scanning microscope	779:814	The morphology of microparticle was observed under scanning electron microscopy, and FITC-dextran-derived green fluorescence images were determined using a confocal laser scanning microscope.
32764929	9	25	theme	appropriate	1336:1346	arg1	shrinkage					1355:1363	appropriate volume shrinkage	1336:1363	appropriate volume shrinkage	1336:1363	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	8	26	theme	drug	1095:1098	arg1	drug					1095:1098	drug	1095:1098	drug	1095:1098	Finally, the amount of drug released could be estimated quantitatively used the structural color or the reflection peak position.
32764929	8	26	theme	drug	1095:1098	arg1	amount					1085:1090	the amount	1081:1090	the amount of drug released	1081:1107	Finally, the amount of drug released could be estimated quantitatively used the structural color or the reflection peak position.
32764929	5	27	theme	microparticle	643:655	arg1	morphology					629:638	The morphology	625:638	The morphology of microparticle	625:655	The morphology of microparticle was observed under scanning electron microscopy, and FITC-dextran-derived green fluorescence images were determined using a confocal laser scanning microscope.
32764929	14	28	theme	delivery	2063:2070	arg1	systems					2072:2078	drug delivery systems	2058:2078	drug delivery systems	2058:2078	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	12	29	theme	NIR	1716:1718	arg1	irradiation					1720:1730	NIR irradiation	1716:1730	NIR irradiation	1716:1730	With an increasing duration of NIR irradiation, the microparticles gradually shrank, the reflection peak shifted toward blue and the structural color changed from red to orange, yellow, green, cyan, and blue successively.
32764929	4	30	theme	hydrogel	503:510	arg1	scaffolds					525:533	GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds	477:533	GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds	477:533	MATERIALS AND METHODS Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template.
32764929	1	31	theme	BACKGROUND	98:107	arg1	DDSs					147:150	DDSs	147:150	DDSs	147:150	BACKGROUND Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development.
32764929	1	31	theme	BACKGROUND	98:107	arg1	systems					138:144	BACKGROUND Particle-based drug delivery systems	98:144	BACKGROUND Particle-based drug delivery systems (DDSs)	98:151	BACKGROUND Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development.
32764929	3	32	theme	controlled	379:388	arg1	NIR					374:376	NIR	374:376	NIR	374:376	AIM To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.
32764929	3	32	theme	controlled	379:388	arg1	release					390:396	near-infrared (NIR) controlled release	359:396	near-infrared (NIR) controlled release	359:396	AIM To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.
32764929	4	33	theme	opal	520:523	arg1	scaffolds					525:533	GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds	477:533	GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds	477:533	MATERIALS AND METHODS Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template.
32764929	0	34	theme	Intelligent	0:10	arg1	Delivery					17:24	Intelligent Drug Delivery	0:24	Intelligent Drug Delivery	0:24	Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes.
32764929	9	35	theme	structure	1369:1377	arg1	color					1379:1383	structure color	1369:1383	structure color	1369:1383	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	14	36	from	potential	2045:2053	arg1	systems					2072:2078	drug delivery systems	2058:2078	drug delivery systems	2058:2078	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	1	37	theme	drug	124:127	arg1	DDSs					147:150	DDSs	147:150	DDSs	147:150	BACKGROUND Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development.
32764929	1	37	theme	drug	124:127	arg1	systems					138:144	BACKGROUND Particle-based drug delivery systems	98:144	BACKGROUND Particle-based drug delivery systems (DDSs)	98:151	BACKGROUND Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development.
32764929	8	38	used	used	1143:1146	arg2	amount					1085:1090	the amount	1081:1090	the amount of drug released	1081:1107	Finally, the amount of drug released could be estimated quantitatively used the structural color or the reflection peak position.
32764929	8	38	used	used	1143:1146	arg2	drug					1095:1098	drug	1095:1098	drug	1095:1098	Finally, the amount of drug released could be estimated quantitatively used the structural color or the reflection peak position.
32764929	14	39	theme	excellent	2118:2126	arg1	effect					2141:2146	excellent photothermal effect	2118:2146	excellent photothermal effect	2118:2146	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	4	40	with	METHODS	443:449	arg1	dextran					541:547	dextran	541:547	dextran	541:547	MATERIALS AND METHODS Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template.
32764929	4	40	with	METHODS	443:449	arg1	alginate					561:568	calcium alginate	553:568	calcium alginate	553:568	MATERIALS AND METHODS Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template.
32764929	3	41	theme	color	414:418	arg1	changes					420:426	macroscopic color changes	402:426	macroscopic color changes	402:426	AIM To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.
32764929	4	42	with	MATERIALS	429:437	arg1	dextran					541:547	dextran	541:547	dextran	541:547	MATERIALS AND METHODS Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template.
32764929	4	42	with	MATERIALS	429:437	arg1	alginate					561:568	calcium alginate	553:568	calcium alginate	553:568	MATERIALS AND METHODS Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template.
32764929	8	43	theme	structural	1152:1161	arg1	color					1163:1167	the structural color	1148:1167	the structural color	1148:1167	Finally, the amount of drug released could be estimated quantitatively used the structural color or the reflection peak position.
32764929	4	44	theme	calcium	553:559	arg1	alginate					561:568	calcium alginate	553:568	calcium alginate	553:568	MATERIALS AND METHODS Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template.
32764929	14	45	theme	vivid	2095:2099	arg1	color					2111:2115	its vivid reporting color	2091:2115	its vivid reporting color	2091:2115	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	6	46	theme	drug	828:831	arg1	release					833:839	the drug release	824:839	the drug release	824:839	During the drug release, FITC-dextran-derived green fluorescence images were captured using fluorescent inverted microscope.
32764929	0	47	theme	Stimuli-Responsive	53:70	arg1	Changes					89:95	Visual Stimuli-Responsive Structural Color Changes	46:95	Visual Stimuli-Responsive Structural Color Changes	46:95	Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes.
32764929	6	48	theme	fluorescence	869:880	arg1	images					882:887	FITC-dextran-derived green fluorescence images	842:887	FITC-dextran-derived green fluorescence images	842:887	During the drug release, FITC-dextran-derived green fluorescence images were captured using fluorescent inverted microscope.
32764929	11	49	theme	same	1649:1652	arg1	time					1654:1657	the same time	1645:1657	the same time	1645:1657	The microcarriers shrank because of the photothermal response and the intrinsic fluorescence intensity of FITC-dextran in the microparticles gradually decreased at the same time, indicating drug release.
32764929	8	50	theme	reflection	1176:1185	arg1	position					1192:1199	the reflection peak position	1172:1199	the reflection peak position	1172:1199	Finally, the amount of drug released could be estimated quantitatively used the structural color or the reflection peak position.
32764929	6	51	theme	inverted	921:928	arg1	microscope					930:939	fluorescent inverted microscope	909:939	fluorescent inverted microscope	909:939	During the drug release, FITC-dextran-derived green fluorescence images were captured using fluorescent inverted microscope.
32764929	9	52	theme	concentration	1218:1230	arg1	GO					1264:1265	GO	1264:1265	GO	1264:1265	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	52	theme	concentration	1218:1230	arg1	v/v					1236:1238	v/v	1236:1238	v/v	1236:1238	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	52	theme	concentration	1218:1230	arg1	PEGDA					1244:1248	PEGDA	1244:1248	PEGDA	1244:1248	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	52	theme	concentration	1218:1230	arg1	%					1233:1233	A fixed concentration 8%	1210:1233	A fixed concentration 8% (v/v) of PEGDA	1210:1248	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	7	53	theme	drug	992:995	arg1	rate					1005:1008	the drug release rate	988:1008	the drug release rate	988:1008	The relationship between the power of NIR and the drug release rate was obtained using the change in optical density (OD) values.
32764929	4	54	dep	MATERIALS	429:437	arg1	Microparticles					451:464	Microparticles	451:464	Microparticles	451:464	MATERIALS AND METHODS Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template.
32764929	11	55	theme	drug	1671:1674	arg1	release					1676:1682	drug release	1671:1682	drug release	1671:1682	The microcarriers shrank because of the photothermal response and the intrinsic fluorescence intensity of FITC-dextran in the microparticles gradually decreased at the same time, indicating drug release.
32764929	13	56	theme	drug	1911:1914	arg1	quantity					1924:1931	The drug release quantity	1907:1931	The drug release quantity	1907:1931	The drug release quantity can be predicted by the structural color of microparticles.
32764929	12	57	theme	structural	1818:1827	arg1	color					1829:1833	the structural color	1814:1833	the structural color	1814:1833	With an increasing duration of NIR irradiation, the microparticles gradually shrank, the reflection peak shifted toward blue and the structural color changed from red to orange, yellow, green, cyan, and blue successively.
32764929	6	58	theme	green	863:867	arg1	images					882:887	FITC-dextran-derived green fluorescence images	842:887	FITC-dextran-derived green fluorescence images	842:887	During the drug release, FITC-dextran-derived green fluorescence images were captured using fluorescent inverted microscope.
32764929	14	59	contain	have	2034:2037	arg1	microparticles					2019:2032	The multicolor microparticles	2004:2032	The multicolor microparticles	2004:2032	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	14	59	contain	have	2034:2037	arg2	potential					2045:2053	great potential	2039:2053	great potential in drug delivery systems	2039:2078	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	11	60	theme	FITC-dextran	1587:1598	arg1	intensity					1574:1582	the intrinsic fluorescence intensity	1547:1582	the intrinsic fluorescence intensity of FITC-dextran in the microparticles	1547:1620	The microcarriers shrank because of the photothermal response and the intrinsic fluorescence intensity of FITC-dextran in the microparticles gradually decreased at the same time, indicating drug release.
32764929	1	61	theme	drug	183:186	arg1	discovery					188:196	drug discovery	183:196	drug discovery	183:196	BACKGROUND Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development.
32764929	5	62	theme	scanning	676:683	arg1	microscopy					694:703	scanning electron microscopy	676:703	scanning electron microscopy	676:703	The morphology of microparticle was observed under scanning electron microscopy, and FITC-dextran-derived green fluorescence images were determined using a confocal laser scanning microscope.
32764929	10	63	theme	wt	1460:1461	arg1	alginate					1471:1478	0.2 wt% sodium alginate	1456:1478	0.2 wt% sodium alginate	1456:1478	The FITC-dextran was uniformly encapsulated in the particles by using 0.2 wt% sodium alginate.
32764929	13	64	theme	structural	1957:1966	arg1	color					1968:1972	the structural color	1953:1972	the structural color of microparticles	1953:1990	The drug release quantity can be predicted by the structural color of microparticles.
32764929	13	65	theme	microparticles	1977:1990	arg1	color					1968:1972	the structural color	1953:1972	the structural color of microparticles	1953:1990	The drug release quantity can be predicted by the structural color of microparticles.
32764929	4	66	theme	composite	493:501	arg1	scaffolds					525:533	GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds	477:533	GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds	477:533	MATERIALS AND METHODS Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template.
32764929	5	67	theme	green	731:735	arg1	images					750:755	FITC-dextran-derived green fluorescence images	710:755	FITC-dextran-derived green fluorescence images	710:755	The morphology of microparticle was observed under scanning electron microscopy, and FITC-dextran-derived green fluorescence images were determined using a confocal laser scanning microscope.
32764929	9	68	theme	optimal	1285:1291	arg1	RESULTS					1202:1208	RESULTS	1202:1208	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO	1202:1265	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	68	theme	optimal	1285:1291	arg1	concentration					1293:1305	the optimal concentration	1281:1305	the optimal concentration based on the balance between appropriate volume shrinkage and structure color	1281:1383	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	14	69	dep	CONCLUSION	1993:2002	arg1	have					2034:2037	have	2034:2037	have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity	2034:2181	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	12	70	theme	reflection	1774:1783	arg1	peak					1785:1788	the reflection peak	1770:1788	the reflection peak shifted toward blue and the structural color	1770:1833	With an increasing duration of NIR irradiation, the microparticles gradually shrank, the reflection peak shifted toward blue and the structural color changed from red to orange, yellow, green, cyan, and blue successively.
32764929	3	71	with	DDSs	344:347	arg1	NIR					374:376	NIR	374:376	NIR	374:376	AIM To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.
32764929	3	71	with	DDSs	344:347	arg1	release					390:396	near-infrared (NIR) controlled release	359:396	near-infrared (NIR) controlled release	359:396	AIM To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.
32764929	3	71	with	DDSs	344:347	arg1	changes					420:426	macroscopic color changes	402:426	macroscopic color changes	402:426	AIM To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.
32764929	11	72	theme	fluorescence	1561:1572	arg1	intensity					1574:1582	the intrinsic fluorescence intensity	1547:1582	the intrinsic fluorescence intensity of FITC-dextran in the microparticles	1547:1620	The microcarriers shrank because of the photothermal response and the intrinsic fluorescence intensity of FITC-dextran in the microparticles gradually decreased at the same time, indicating drug release.
32764929	3	73	theme	intelligent	321:331	arg1	DDSs					344:347	an intelligent multicolor DDSs	318:347	an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes	318:426	AIM To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.
32764929	14	74	theme	stimuli	2162:2168	arg1	responsivity					2170:2181	the good stimuli responsivity	2153:2181	the good stimuli responsivity	2153:2181	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	5	75	theme	laser	790:794	arg1	microscope					805:814	a confocal laser scanning microscope	779:814	a confocal laser scanning microscope	779:814	The morphology of microparticle was observed under scanning electron microscopy, and FITC-dextran-derived green fluorescence images were determined using a confocal laser scanning microscope.
32764929	7	76	theme	density	1051:1057	arg1	values					1064:1069	optical density (OD) values	1043:1069	optical density (OD) values	1043:1069	The relationship between the power of NIR and the drug release rate was obtained using the change in optical density (OD) values.
32764929	4	77	theme	inverse	512:518	arg1	scaffolds					525:533	GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds	477:533	GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds	477:533	MATERIALS AND METHODS Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template.
32764929	10	78	theme	sodium	1464:1469	arg1	alginate					1471:1478	0.2 wt% sodium alginate	1456:1478	0.2 wt% sodium alginate	1456:1478	The FITC-dextran was uniformly encapsulated in the particles by using 0.2 wt% sodium alginate.
32764929	9	79	dep	RESULTS	1202:1208	arg1	GO					1264:1265	GO	1264:1265	GO	1264:1265	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	79	dep	RESULTS	1202:1208	arg1	4mg/mL					1254:1259	4mg/mL	1254:1259	4mg/mL of GO	1254:1265	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	79	dep	RESULTS	1202:1208	arg1	v/v					1236:1238	v/v	1236:1238	v/v	1236:1238	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	79	dep	RESULTS	1202:1208	arg1	PEGDA					1244:1248	PEGDA	1244:1248	PEGDA	1244:1248	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	79	dep	RESULTS	1202:1208	arg1	%					1233:1233	A fixed concentration 8%	1210:1233	A fixed concentration 8% (v/v) of PEGDA	1210:1248	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	14	80	theme	drug	2058:2061	arg1	systems					2072:2078	drug delivery systems	2058:2078	drug delivery systems	2058:2078	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	0	81	theme	Drug	12:15	arg1	Delivery					17:24	Intelligent Drug Delivery	0:24	Intelligent Drug Delivery	0:24	Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes.
32764929	1	82	theme	Particle-based	109:122	arg1	DDSs					147:150	DDSs	147:150	DDSs	147:150	BACKGROUND Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development.
32764929	1	82	theme	Particle-based	109:122	arg1	systems					138:144	BACKGROUND Particle-based drug delivery systems	98:144	BACKGROUND Particle-based drug delivery systems (DDSs)	98:151	BACKGROUND Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development.
32764929	9	83	theme	volume	1348:1353	arg1	shrinkage					1355:1363	appropriate volume shrinkage	1336:1363	appropriate volume shrinkage	1336:1363	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	14	84	theme	photothermal	2128:2139	arg1	effect					2141:2146	excellent photothermal effect	2118:2146	excellent photothermal effect	2118:2146	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	1	85	theme	delivery	129:136	arg1	DDSs					147:150	DDSs	147:150	DDSs	147:150	BACKGROUND Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development.
32764929	1	85	theme	delivery	129:136	arg1	systems					138:144	BACKGROUND Particle-based drug delivery systems	98:144	BACKGROUND Particle-based drug delivery systems (DDSs)	98:151	BACKGROUND Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development.
32764929	5	86	link	FITC-dextran-derived	710:729	arg1	images					750:755	FITC-dextran-derived green fluorescence images	710:755	FITC-dextran-derived green fluorescence images	710:755	The morphology of microparticle was observed under scanning electron microscopy, and FITC-dextran-derived green fluorescence images were determined using a confocal laser scanning microscope.
32764929	0	87	theme	Visual	46:51	arg1	Changes					89:95	Visual Stimuli-Responsive Structural Color Changes	46:95	Visual Stimuli-Responsive Structural Color Changes	46:95	Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes.
32764929	14	88	theme	multicolor	2008:2017	arg1	microparticles					2019:2032	The multicolor microparticles	2004:2032	The multicolor microparticles	2004:2032	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	12	89	theme	increasing	1693:1702	arg1	duration					1704:1711	an increasing duration	1690:1711	an increasing duration of NIR irradiation	1690:1730	With an increasing duration of NIR irradiation, the microparticles gradually shrank, the reflection peak shifted toward blue and the structural color changed from red to orange, yellow, green, cyan, and blue successively.
32764929	14	90	theme	reporting	2101:2109	arg1	color					2111:2115	its vivid reporting color	2091:2115	its vivid reporting color	2091:2115	CONCLUSION The multicolor microparticles have great potential in drug delivery systems because of its vivid reporting color, excellent photothermal effect, and the good stimuli responsivity.
32764929	0	91	theme	Structural	72:81	arg1	Changes					89:95	Visual Stimuli-Responsive Structural Color Changes	46:95	Visual Stimuli-Responsive Structural Color Changes	46:95	Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes.
32764929	4	92	dep	dextran	541:547	arg1	hydrogel					570:577	hydrogel	570:577	hydrogel	570:577	MATERIALS AND METHODS Microparticles comprising GO/pNIPAM/PEGDA composite hydrogel inverse opal scaffolds, with dextran and calcium alginate hydrogel were synthesized using SCCBs as the template.
32764929	3	93	theme	macroscopic	402:412	arg1	changes					420:426	macroscopic color changes	402:426	macroscopic color changes	402:426	AIM To develop an intelligent multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic color changes.
32764929	7	94	theme	release	997:1003	arg1	rate					1005:1008	the drug release rate	988:1008	the drug release rate	988:1008	The relationship between the power of NIR and the drug release rate was obtained using the change in optical density (OD) values.
32764929	8	95	theme	peak	1187:1190	arg1	position					1192:1199	the reflection peak position	1172:1199	the reflection peak position	1172:1199	Finally, the amount of drug released could be estimated quantitatively used the structural color or the reflection peak position.
32764929	11	96	from	intensity	1574:1582	arg1	microparticles					1607:1620	the microparticles	1603:1620	the microparticles	1603:1620	The microcarriers shrank because of the photothermal response and the intrinsic fluorescence intensity of FITC-dextran in the microparticles gradually decreased at the same time, indicating drug release.
32764929	9	97	theme	fixed	1212:1216	arg1	GO					1264:1265	GO	1264:1265	GO	1264:1265	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	97	theme	fixed	1212:1216	arg1	v/v					1236:1238	v/v	1236:1238	v/v	1236:1238	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	97	theme	fixed	1212:1216	arg1	PEGDA					1244:1248	PEGDA	1244:1248	PEGDA	1244:1248	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	9	97	theme	fixed	1212:1216	arg1	%					1233:1233	A fixed concentration 8%	1210:1233	A fixed concentration 8% (v/v) of PEGDA	1210:1248	RESULTS A fixed concentration 8% (v/v) of PEGDA and 4mg/mL of GO was chosen as the optimal concentration based on the balance between appropriate volume shrinkage and structure color.
32764929	6	98	theme	fluorescent	909:919	arg1	microscope					930:939	fluorescent inverted microscope	909:939	fluorescent inverted microscope	909:939	During the drug release, FITC-dextran-derived green fluorescence images were captured using fluorescent inverted microscope.
32764929	8	99	dep	estimated	1118:1126	arg1	used					1143:1146	used	1143:1146	could be estimated quantitatively used the structural color or the reflection peak position	1109:1199	Finally, the amount of drug released could be estimated quantitatively used the structural color or the reflection peak position.
32764929	1	100	contain	have	153:156	arg2	value					173:177	a demonstrated value	158:177	a demonstrated value for drug discovery and development	158:212	BACKGROUND Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development.
32764929	1	100	contain	have	153:156	arg1	DDSs					147:150	DDSs	147:150	DDSs	147:150	BACKGROUND Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development.
32764929	1	100	contain	have	153:156	arg1	systems					138:144	BACKGROUND Particle-based drug delivery systems	98:144	BACKGROUND Particle-based drug delivery systems (DDSs)	98:151	BACKGROUND Particle-based drug delivery systems (DDSs) have a demonstrated value for drug discovery and development.
32764929	7	101	theme	NIR	980:982	arg1	power					971:975	the power	967:975	the power of NIR	967:982	The relationship between the power of NIR and the drug release rate was obtained using the change in optical density (OD) values.
32764929	7	101	theme	NIR	980:982	arg1	rate					1005:1008	the drug release rate	988:1008	the drug release rate	988:1008	The relationship between the power of NIR and the drug release rate was obtained using the change in optical density (OD) values.
33545844	1	0	theme	biomedical	193:202	arg1	applications					204:215	biomedical applications	193:215	biomedical applications	193:215	Ethylcellulose is a biocompatible polymer attracting increasing interest for biomedical applications.
33545844	0	1	theme	haemocompatible	89:103	arg1	platforms					105:113	new folate binding haemocompatible platforms	70:113	new folate binding haemocompatible platforms	70:113	Ethylcellulose nanoparticles prepared from nano-emulsion templates as new folate binding haemocompatible platforms.
33545844	6	2	theme	excellent	1020:1028	arg1	haemocompatibility					1030:1047	excellent haemocompatibility	1020:1047	excellent haemocompatibility	1020:1047	The complexes prepared with HEPES buffered glucose solution showed excellent haemocompatibility, which make them promising for parenteral therapeutic applications and also for those in which easy access to systemic circulation may occur, like in lungs.
33545844	3	3	theme	potential	581:589	arg1	values					591:596	the zeta potential values	572:596	the zeta potential values	572:596	The composition of the aqueous component is shown to be crucial for the formation of stable nano-emulsions and influences the zeta potential values.
33545844	3	4	theme	aqueous	473:479	arg1	component					481:489	the aqueous component	469:489	the aqueous component	469:489	The composition of the aqueous component is shown to be crucial for the formation of stable nano-emulsions and influences the zeta potential values.
33545844	6	5	theme	therapeutic	1091:1101	arg1	applications					1103:1114	parenteral therapeutic applications	1080:1114	parenteral therapeutic applications	1080:1114	The complexes prepared with HEPES buffered glucose solution showed excellent haemocompatibility, which make them promising for parenteral therapeutic applications and also for those in which easy access to systemic circulation may occur, like in lungs.
33545844	2	6	theme	low-energy	344:353	arg1	approach					355:362	a low-energy approach	342:362	a low-energy approach	342:362	In the present work, the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications has been investigated.
33545844	2	7	theme	suitable	390:397	arg1	components					379:388	aqueous components	371:388	aqueous components suitable for biomedical applications	371:425	In the present work, the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications has been investigated.
33545844	2	8	from	formation	243:251	arg1	templates					320:328	nano-emulsion templates	306:328	nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications	306:425	In the present work, the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications has been investigated.
33545844	6	9	theme	glucose	996:1002	arg1	solution					1004:1011	HEPES buffered glucose solution	981:1011	HEPES buffered glucose solution	981:1011	The complexes prepared with HEPES buffered glucose solution showed excellent haemocompatibility, which make them promising for parenteral therapeutic applications and also for those in which easy access to systemic circulation may occur, like in lungs.
33545844	5	10	theme	potential	929:937	arg1	measurements					939:950	zeta potential measurements	924:950	zeta potential measurements	924:950	The nanoparticles were successfully complexed with folate, as evidenced by both particle size and zeta potential measurements.
33545844	6	11	theme	buffered	987:994	arg1	solution					1004:1011	HEPES buffered glucose solution	981:1011	HEPES buffered glucose solution	981:1011	The complexes prepared with HEPES buffered glucose solution showed excellent haemocompatibility, which make them promising for parenteral therapeutic applications and also for those in which easy access to systemic circulation may occur, like in lungs.
33545844	6	12	theme	easy	1144:1147	arg1	access					1149:1154	easy access	1144:1154	easy access to systemic circulation	1144:1178	The complexes prepared with HEPES buffered glucose solution showed excellent haemocompatibility, which make them promising for parenteral therapeutic applications and also for those in which easy access to systemic circulation may occur, like in lungs.
33545844	4	13	theme	potential	748:756	arg1	values					758:763	positive zeta potential values	734:763	positive zeta potential values	734:763	The ethylcellulose nanoparticles with mean sizes around 100 nm were obtained from the nano-emulsions by solvent evaporation and showed positive zeta potential values above +20 mV due to the presence of the cationic surfactant.
33545844	5	14	theme	particle	906:913	arg1	size					915:918	particle size	906:918	particle size	906:918	The nanoparticles were successfully complexed with folate, as evidenced by both particle size and zeta potential measurements.
33545844	4	15	theme	cationic	805:812	arg1	surfactant					814:823	the cationic surfactant	801:823	the cationic surfactant	801:823	The ethylcellulose nanoparticles with mean sizes around 100 nm were obtained from the nano-emulsions by solvent evaporation and showed positive zeta potential values above +20 mV due to the presence of the cationic surfactant.
33545844	2	16	theme	aqueous	371:377	arg1	components					379:388	aqueous components	371:388	aqueous components suitable for biomedical applications	371:425	In the present work, the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications has been investigated.
33545844	0	17	dep	nanoparticles	15:27	arg1	prepared					29:36	prepared	29:36	nanoparticles prepared from nano-emulsion templates as new folate binding haemocompatible platforms	15:113	Ethylcellulose nanoparticles prepared from nano-emulsion templates as new folate binding haemocompatible platforms.
33545844	5	18	theme	zeta	924:927	arg1	measurements					939:950	zeta potential measurements	924:950	zeta potential measurements	924:950	The nanoparticles were successfully complexed with folate, as evidenced by both particle size and zeta potential measurements.
33545844	4	19	with	nanoparticles	618:630	arg1	sizes					642:646	mean sizes	637:646	mean sizes around 100 nm	637:660	The ethylcellulose nanoparticles with mean sizes around 100 nm were obtained from the nano-emulsions by solvent evaporation and showed positive zeta potential values above +20 mV due to the presence of the cationic surfactant.
33545844	6	20	theme	parenteral	1080:1089	arg1	applications					1103:1114	parenteral therapeutic applications	1080:1114	parenteral therapeutic applications	1080:1114	The complexes prepared with HEPES buffered glucose solution showed excellent haemocompatibility, which make them promising for parenteral therapeutic applications and also for those in which easy access to systemic circulation may occur, like in lungs.
33545844	2	21	theme	present	225:231	arg1	work					233:236	the present work	221:236	the present work	221:236	In the present work, the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications has been investigated.
33545844	3	22	theme	stable	535:540	arg1	nano-emulsions					542:555	stable nano-emulsions	535:555	stable nano-emulsions	535:555	The composition of the aqueous component is shown to be crucial for the formation of stable nano-emulsions and influences the zeta potential values.
33545844	3	23	theme	zeta	576:579	arg1	values					591:596	the zeta potential values	572:596	the zeta potential values	572:596	The composition of the aqueous component is shown to be crucial for the formation of stable nano-emulsions and influences the zeta potential values.
33545844	2	24	theme	biomedical	403:412	arg1	applications					414:425	biomedical applications	403:425	biomedical applications	403:425	In the present work, the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications has been investigated.
33545844	6	25	theme	systemic	1159:1166	arg1	circulation					1168:1178	systemic circulation	1159:1178	systemic circulation	1159:1178	The complexes prepared with HEPES buffered glucose solution showed excellent haemocompatibility, which make them promising for parenteral therapeutic applications and also for those in which easy access to systemic circulation may occur, like in lungs.
33545844	2	26	theme	complexes	291:299	arg1	formation					243:251	the formation	239:251	the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications	239:425	In the present work, the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications has been investigated.
33545844	2	27	from	templates	320:328	arg1	complexes					291:299	folate-ethylcellulose nanoparticle complexes	256:299	folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications	256:425	In the present work, the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications has been investigated.
33545844	2	27	from	templates	320:328	arg1	formation					243:251	the formation	239:251	the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications	239:425	In the present work, the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications has been investigated.
33545844	4	28	theme	zeta	743:746	arg1	values					758:763	positive zeta potential values	734:763	positive zeta potential values	734:763	The ethylcellulose nanoparticles with mean sizes around 100 nm were obtained from the nano-emulsions by solvent evaporation and showed positive zeta potential values above +20 mV due to the presence of the cationic surfactant.
33545844	0	29	theme	nano-emulsion	43:55	arg1	templates					57:65	nano-emulsion templates	43:65	nano-emulsion templates	43:65	Ethylcellulose nanoparticles prepared from nano-emulsion templates as new folate binding haemocompatible platforms.
33545844	4	30	theme	ethylcellulose	603:616	arg1	nanoparticles					618:630	The ethylcellulose nanoparticles	599:630	The ethylcellulose nanoparticles with mean sizes around 100 nm	599:660	The ethylcellulose nanoparticles with mean sizes around 100 nm were obtained from the nano-emulsions by solvent evaporation and showed positive zeta potential values above +20 mV due to the presence of the cationic surfactant.
33545844	2	31	theme	nanoparticle	278:289	arg1	complexes					291:299	folate-ethylcellulose nanoparticle complexes	256:299	folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications	256:425	In the present work, the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications has been investigated.
33545844	4	32	theme	positive	734:741	arg1	values					758:763	positive zeta potential values	734:763	positive zeta potential values	734:763	The ethylcellulose nanoparticles with mean sizes around 100 nm were obtained from the nano-emulsions by solvent evaporation and showed positive zeta potential values above +20 mV due to the presence of the cationic surfactant.
33545844	0	33	theme	new	70:72	arg1	platforms					105:113	new folate binding haemocompatible platforms	70:113	new folate binding haemocompatible platforms	70:113	Ethylcellulose nanoparticles prepared from nano-emulsion templates as new folate binding haemocompatible platforms.
33545844	4	34	theme	mean	637:640	arg1	sizes					642:646	mean sizes	637:646	mean sizes around 100 nm	637:660	The ethylcellulose nanoparticles with mean sizes around 100 nm were obtained from the nano-emulsions by solvent evaporation and showed positive zeta potential values above +20 mV due to the presence of the cationic surfactant.
33545844	2	35	theme	folate-ethylcellulose	256:276	arg1	complexes					291:299	folate-ethylcellulose nanoparticle complexes	256:299	folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications	256:425	In the present work, the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications has been investigated.
33545844	1	36	theme	biocompatible	136:148	arg1	Ethylcellulose					116:129	Ethylcellulose	116:129	Ethylcellulose	116:129	Ethylcellulose is a biocompatible polymer attracting increasing interest for biomedical applications.
33545844	1	36	theme	biocompatible	136:148	arg1	interest					180:187	a biocompatible polymer attracting increasing interest	134:187	a biocompatible polymer attracting increasing interest for biomedical applications	134:215	Ethylcellulose is a biocompatible polymer attracting increasing interest for biomedical applications.
33545844	3	37	theme	component	481:489	arg1	crucial					506:512	crucial	506:512	crucial	506:512	The composition of the aqueous component is shown to be crucial for the formation of stable nano-emulsions and influences the zeta potential values.
33545844	3	37	theme	component	481:489	arg1	composition					454:464	The composition	450:464	The composition of the aqueous component	450:489	The composition of the aqueous component is shown to be crucial for the formation of stable nano-emulsions and influences the zeta potential values.
33545844	1	38	theme	polymer	150:156	arg1	Ethylcellulose					116:129	Ethylcellulose	116:129	Ethylcellulose	116:129	Ethylcellulose is a biocompatible polymer attracting increasing interest for biomedical applications.
33545844	1	38	theme	polymer	150:156	arg1	interest					180:187	a biocompatible polymer attracting increasing interest	134:187	a biocompatible polymer attracting increasing interest for biomedical applications	134:215	Ethylcellulose is a biocompatible polymer attracting increasing interest for biomedical applications.
33545844	1	39	theme	attracting	158:167	arg1	Ethylcellulose					116:129	Ethylcellulose	116:129	Ethylcellulose	116:129	Ethylcellulose is a biocompatible polymer attracting increasing interest for biomedical applications.
33545844	1	39	theme	attracting	158:167	arg1	interest					180:187	a biocompatible polymer attracting increasing interest	134:187	a biocompatible polymer attracting increasing interest for biomedical applications	134:215	Ethylcellulose is a biocompatible polymer attracting increasing interest for biomedical applications.
33545844	4	40	theme	surfactant	814:823	arg1	presence					789:796	the presence	785:796	the presence of the cationic surfactant	785:823	The ethylcellulose nanoparticles with mean sizes around 100 nm were obtained from the nano-emulsions by solvent evaporation and showed positive zeta potential values above +20 mV due to the presence of the cationic surfactant.
33545844	1	41	theme	increasing	169:178	arg1	Ethylcellulose					116:129	Ethylcellulose	116:129	Ethylcellulose	116:129	Ethylcellulose is a biocompatible polymer attracting increasing interest for biomedical applications.
33545844	1	41	theme	increasing	169:178	arg1	interest					180:187	a biocompatible polymer attracting increasing interest	134:187	a biocompatible polymer attracting increasing interest for biomedical applications	134:215	Ethylcellulose is a biocompatible polymer attracting increasing interest for biomedical applications.
33545844	3	42	theme	nano-emulsions	542:555	arg1	formation					522:530	the formation	518:530	the formation of stable nano-emulsions	518:555	The composition of the aqueous component is shown to be crucial for the formation of stable nano-emulsions and influences the zeta potential values.
33545844	0	43	theme	binding	81:87	arg1	platforms					105:113	new folate binding haemocompatible platforms	70:113	new folate binding haemocompatible platforms	70:113	Ethylcellulose nanoparticles prepared from nano-emulsion templates as new folate binding haemocompatible platforms.
33545844	2	44	theme	nano-emulsion	306:318	arg1	templates					320:328	nano-emulsion templates	306:328	nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications	306:425	In the present work, the formation of folate-ethylcellulose nanoparticle complexes from nano-emulsion templates prepared by a low-energy approach, using aqueous components suitable for biomedical applications has been investigated.
33545844	0	45	theme	folate	74:79	arg1	platforms					105:113	new folate binding haemocompatible platforms	70:113	new folate binding haemocompatible platforms	70:113	Ethylcellulose nanoparticles prepared from nano-emulsion templates as new folate binding haemocompatible platforms.
33545844	4	46	theme	solvent	703:709	arg1	evaporation					711:721	solvent evaporation	703:721	solvent evaporation	703:721	The ethylcellulose nanoparticles with mean sizes around 100 nm were obtained from the nano-emulsions by solvent evaporation and showed positive zeta potential values above +20 mV due to the presence of the cationic surfactant.
34114573	3	0	theme	magnetic	739:746	arg1	extraction					760:769	magnetic solid-phase extraction	739:769	magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion	739:810	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	3	0	theme	magnetic	739:746	arg1	MSPE					772:775	MSPE	772:775	MSPE	772:775	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	2	1	theme	magnetic	329:336	arg1	monomer					472:478	the functional monomer	457:478	the functional monomer	457:478	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	2	1	theme	magnetic	329:336	arg1	glycol					493:498	ethylene glycol	484:498	ethylene glycol	484:498	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	2	1	theme	magnetic	329:336	arg1	microparticles					367:380	The magnetic β-cyclodextrin copolymerized microparticles	325:380	The magnetic β-cyclodextrin copolymerized microparticles	325:380	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	7	2	theme	satisfactory	1466:1477	arg1	recoveries					1479:1488	satisfactory recoveries	1466:1488	satisfactory recoveries between 89.2-101.2%	1466:1508	The proposed method was applied for the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%, and relative standard deviations were less than 9.1%.
34114573	4	3	theme	desorption	934:943	arg1	adsorption					919:928	adsorption	919:928	adsorption	919:928	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	4	3	theme	desorption	934:943	arg1	times					945:949	desorption times	934:949	desorption times	934:949	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	4	3	theme	desorption	934:943	arg1	type					898:901	desorption solvent type	879:901	desorption solvent type	879:901	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	4	3	theme	desorption	934:943	arg1	pH					856:857	sample pH	849:857	sample pH	849:857	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	4	3	theme	desorption	934:943	arg1	strength					869:876	ionic strength	863:876	ionic strength	863:876	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	6	4	theme	=	1205:1205	arg1	kg-1					1141:1144	1.0-200 μg kg-1	1130:1144	1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion	1130:1179	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	6	4	theme	=	1205:1205	arg1	R2					1202:1203	R2 = 0.9978	1202:1212	R2 = 0.9978	1202:1212	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	6	5	theme	0.3	1275:1277	arg1	μg					1279:1280	μg	1279:1280	μg	1279:1280	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	1	6	theme	methyl	245:250	arg1	parathion					252:260	methyl parathion	245:260	methyl parathion	245:260	In this study, magnetic Fe3O4@SiO2@β-cyclodextrin copolymerized microparticles were synthesized and applied for the extraction of methyl parathion and fenthion in lettuce samples followed by HPLC-UV detection.
34114573	2	7	with	polymerization	410:423	arg1	β-cyclodextrin					439:452	acryloyl β-cyclodextrin	430:452	acryloyl β-cyclodextrin	430:452	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	6	8	theme	detection	1260:1268	arg1	limits					1250:1255	the limits	1246:1255	the limits of detection	1246:1268	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	6	8	theme	detection	1260:1268	arg1	kg-1					1282:1285	0.3 μg kg-1	1275:1285	0.3 μg kg-1 for methyl parathion	1275:1306	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	1	9	theme	@	144:144	arg1	β-cyclodextrin					150:163	magnetic Fe3O4@SiO2@β-cyclodextrin	130:163	magnetic Fe3O4@SiO2@β-cyclodextrin	130:163	In this study, magnetic Fe3O4@SiO2@β-cyclodextrin copolymerized microparticles were synthesized and applied for the extraction of methyl parathion and fenthion in lettuce samples followed by HPLC-UV detection.
34114573	7	10	theme	fenthion	1441:1448	arg1	determination					1403:1415	the determination	1399:1415	the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%	1399:1508	The proposed method was applied for the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%, and relative standard deviations were less than 9.1%.
34114573	6	11	theme	μg	1193:1194	arg1	kg-1					1196:1199	1.5-200 μg kg-1	1185:1199	1.5-200 μg kg-1	1185:1199	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	1	12	theme	@	149:149	arg1	β-cyclodextrin					150:163	magnetic Fe3O4@SiO2@β-cyclodextrin	130:163	magnetic Fe3O4@SiO2@β-cyclodextrin	130:163	In this study, magnetic Fe3O4@SiO2@β-cyclodextrin copolymerized microparticles were synthesized and applied for the extraction of methyl parathion and fenthion in lettuce samples followed by HPLC-UV detection.
34114573	0	13	theme	lettuce	98:104	arg1	samples					106:112	lettuce samples	98:112	lettuce samples	98:112	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.
34114573	3	14	theme	composite	540:548	arg1	adsorbent					726:734	adsorbent	726:734	adsorbent	726:734	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	3	14	theme	composite	540:548	arg1	microparticles					559:572	The composite magnetic microparticles	536:572	The composite magnetic microparticles	536:572	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	7	15	theme	proposed	1367:1374	arg1	method					1376:1381	The proposed method	1363:1381	The proposed method	1363:1381	The proposed method was applied for the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%, and relative standard deviations were less than 9.1%.
34114573	1	16	from	extraction	231:240	arg1	samples					286:292	lettuce samples	278:292	lettuce samples followed by HPLC-UV detection	278:322	In this study, magnetic Fe3O4@SiO2@β-cyclodextrin copolymerized microparticles were synthesized and applied for the extraction of methyl parathion and fenthion in lettuce samples followed by HPLC-UV detection.
34114573	3	17	theme	magnetic	656:663	arg1	spectroscopy					623:634	spectroscopy	623:634	spectroscopy	623:634	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	3	17	theme	magnetic	656:663	arg1	measurement					665:675	magnetic measurement	656:675	magnetic measurement	656:675	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	6	18	theme	methyl	1291:1296	arg1	parathion					1298:1306	methyl parathion	1291:1306	methyl parathion	1291:1306	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	7	19	theme	methyl	1420:1425	arg1	parathion					1427:1435	methyl parathion	1420:1435	methyl parathion	1420:1435	The proposed method was applied for the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%, and relative standard deviations were less than 9.1%.
34114573	5	20	theme	extraction	985:994	arg1	conditions					996:1005	the optimal extraction conditions	973:1005	the optimal extraction conditions	973:1005	Under the optimal extraction conditions, an MSPE-HPLC-UV method was developed for the detection of methyl parathion and fenthion in lettuce.
34114573	0	21	theme	phase	45:49	arg1	extraction					51:60	solid phase extraction	39:60	solid phase extraction of methyl parathion and fenthion	39:93	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.
34114573	1	22	theme	HPLC-UV	306:312	arg1	detection					314:322	HPLC-UV detection	306:322	HPLC-UV detection	306:322	In this study, magnetic Fe3O4@SiO2@β-cyclodextrin copolymerized microparticles were synthesized and applied for the extraction of methyl parathion and fenthion in lettuce samples followed by HPLC-UV detection.
34114573	7	23	from	determination	1403:1415	arg1	lettuce					1453:1459	lettuce	1453:1459	lettuce with satisfactory recoveries between 89.2-101.2%	1453:1508	The proposed method was applied for the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%, and relative standard deviations were less than 9.1%.
34114573	1	24	theme	fenthion	266:273	arg1	extraction					231:240	the extraction	227:240	the extraction of methyl parathion and fenthion in lettuce samples followed by HPLC-UV detection	227:322	In this study, magnetic Fe3O4@SiO2@β-cyclodextrin copolymerized microparticles were synthesized and applied for the extraction of methyl parathion and fenthion in lettuce samples followed by HPLC-UV detection.
34114573	1	25	theme	magnetic	130:137	arg1	β-cyclodextrin					150:163	magnetic Fe3O4@SiO2@β-cyclodextrin	130:163	magnetic Fe3O4@SiO2@β-cyclodextrin	130:163	In this study, magnetic Fe3O4@SiO2@β-cyclodextrin copolymerized microparticles were synthesized and applied for the extraction of methyl parathion and fenthion in lettuce samples followed by HPLC-UV detection.
34114573	3	26	theme	thermogravimetric	682:698	arg1	analysis					700:707	thermogravimetric analysis	682:707	thermogravimetric analysis	682:707	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	3	26	theme	thermogravimetric	682:698	arg1	spectroscopy					623:634	spectroscopy	623:634	spectroscopy	623:634	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	4	27	theme	extraction	817:826	arg1	adsorption					919:928	adsorption	919:928	adsorption	919:928	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	4	27	theme	extraction	817:826	arg1	type					898:901	desorption solvent type	879:901	desorption solvent type	879:901	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	4	27	theme	extraction	817:826	arg1	conditions					828:837	The extraction conditions	813:837	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption	813:928	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	4	27	theme	extraction	817:826	arg1	pH					856:857	sample pH	849:857	sample pH	849:857	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	4	27	theme	extraction	817:826	arg1	strength					869:876	ionic strength	863:876	ionic strength	863:876	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	0	28	theme	parathion	72:80	arg1	extraction					51:60	solid phase extraction	39:60	solid phase extraction of methyl parathion and fenthion	39:93	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.
34114573	3	29	dep	Fourier	596:602	arg1	transform					604:612	transform	604:612	transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis,	604:708	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	2	30	theme	dispersion	399:408	arg1	polymerization					410:423	dispersion polymerization	399:423	dispersion polymerization with acryloyl β-cyclodextrin	399:452	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	0	31	theme	fenthion	86:93	arg1	extraction					51:60	solid phase extraction	39:60	solid phase extraction of methyl parathion and fenthion	39:93	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.
34114573	0	32	theme	Magnetic	0:7	arg1	β-cyclodextrin					20:33	Magnetic Fe3O4@SiO2@β-cyclodextrin	0:33	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.	0:113	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.
34114573	1	33	theme	parathion	252:260	arg1	extraction					231:240	the extraction	227:240	the extraction of methyl parathion and fenthion in lettuce samples followed by HPLC-UV detection	227:322	In this study, magnetic Fe3O4@SiO2@β-cyclodextrin copolymerized microparticles were synthesized and applied for the extraction of methyl parathion and fenthion in lettuce samples followed by HPLC-UV detection.
34114573	0	34	theme	@	14:14	arg1	β-cyclodextrin					20:33	Magnetic Fe3O4@SiO2@β-cyclodextrin	0:33	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.	0:113	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.
34114573	6	35	from	fenthion	1328:1335	arg1	lettuce					1340:1346	lettuce	1340:1346	lettuce	1340:1346	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	5	36	theme	MSPE-HPLC-UV	1011:1022	arg1	method					1024:1029	an MSPE-HPLC-UV method	1008:1029	an MSPE-HPLC-UV method	1008:1029	Under the optimal extraction conditions, an MSPE-HPLC-UV method was developed for the detection of methyl parathion and fenthion in lettuce.
34114573	6	37	theme	Wide	1108:1111	arg1	ranges					1120:1125	Wide linear ranges	1108:1125	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion	1108:1226	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	0	38	theme	@	19:19	arg1	β-cyclodextrin					20:33	Magnetic Fe3O4@SiO2@β-cyclodextrin	0:33	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.	0:113	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.
34114573	1	39	theme	lettuce	278:284	arg1	samples					286:292	lettuce samples	278:292	lettuce samples followed by HPLC-UV detection	278:322	In this study, magnetic Fe3O4@SiO2@β-cyclodextrin copolymerized microparticles were synthesized and applied for the extraction of methyl parathion and fenthion in lettuce samples followed by HPLC-UV detection.
34114573	7	40	theme	relative	1515:1522	arg1	deviations					1533:1542	relative standard deviations	1515:1542	relative standard deviations	1515:1542	The proposed method was applied for the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%, and relative standard deviations were less than 9.1%.
34114573	2	41	theme	ethylene	484:491	arg1	glycol					493:498	ethylene glycol	484:498	ethylene glycol	484:498	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	2	41	theme	ethylene	484:491	arg1	microparticles					367:380	The magnetic β-cyclodextrin copolymerized microparticles	325:380	The magnetic β-cyclodextrin copolymerized microparticles	325:380	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	4	42	theme	solvent	890:896	arg1	type					898:901	desorption solvent type	879:901	desorption solvent type	879:901	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	8	43	theme	MSPE-HPLC-UV	1575:1586	arg1	method					1588:1593	the MSPE-HPLC-UV method	1571:1593	the MSPE-HPLC-UV method	1571:1593	Thus, the MSPE-HPLC-UV method has high accuracy and sensitivity for the analysis of methyl parathion and fenthion in lettuce samples.
34114573	4	44	theme	ionic	863:867	arg1	strength					869:876	ionic strength	863:876	ionic strength	863:876	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	3	45	theme	magnetic	550:557	arg1	adsorbent					726:734	adsorbent	726:734	adsorbent	726:734	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	3	45	theme	magnetic	550:557	arg1	microparticles					559:572	The composite magnetic microparticles	536:572	The composite magnetic microparticles	536:572	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	7	46	with	lettuce	1453:1459	arg1	recoveries					1479:1488	satisfactory recoveries	1466:1488	satisfactory recoveries between 89.2-101.2%	1466:1508	The proposed method was applied for the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%, and relative standard deviations were less than 9.1%.
34114573	5	47	theme	methyl	1066:1071	arg1	parathion					1073:1081	methyl parathion	1066:1081	methyl parathion	1066:1081	Under the optimal extraction conditions, an MSPE-HPLC-UV method was developed for the detection of methyl parathion and fenthion in lettuce.
34114573	2	48	theme	β-cyclodextrin	338:351	arg1	monomer					472:478	the functional monomer	457:478	the functional monomer	457:478	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	2	48	theme	β-cyclodextrin	338:351	arg1	glycol					493:498	ethylene glycol	484:498	ethylene glycol	484:498	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	2	48	theme	β-cyclodextrin	338:351	arg1	microparticles					367:380	The magnetic β-cyclodextrin copolymerized microparticles	325:380	The magnetic β-cyclodextrin copolymerized microparticles	325:380	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	8	49	theme	parathion	1656:1664	arg1	fenthion					1670:1677	fenthion	1670:1677	fenthion	1670:1677	Thus, the MSPE-HPLC-UV method has high accuracy and sensitivity for the analysis of methyl parathion and fenthion in lettuce samples.
34114573	8	49	theme	parathion	1656:1664	arg1	analysis					1637:1644	the analysis	1633:1644	the analysis of methyl parathion	1633:1664	Thus, the MSPE-HPLC-UV method has high accuracy and sensitivity for the analysis of methyl parathion and fenthion in lettuce samples.
34114573	6	50	theme	kg-1	1141:1144	arg1	ranges					1120:1125	Wide linear ranges	1108:1125	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion	1108:1226	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	3	51	theme	solid-phase	748:758	arg1	extraction					760:769	magnetic solid-phase extraction	739:769	magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion	739:810	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	3	51	theme	solid-phase	748:758	arg1	MSPE					772:775	MSPE	772:775	MSPE	772:775	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	6	52	theme	μg	1279:1280	arg1	limits					1250:1255	the limits	1246:1255	the limits of detection	1246:1268	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	6	52	theme	μg	1279:1280	arg1	kg-1					1282:1285	0.3 μg kg-1	1275:1285	0.3 μg kg-1 for methyl parathion	1275:1306	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	7	53	theme	parathion	1427:1435	arg1	determination					1403:1415	the determination	1399:1415	the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%	1399:1508	The proposed method was applied for the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%, and relative standard deviations were less than 9.1%.
34114573	3	54	theme	methyl	782:787	arg1	parathion					789:797	methyl parathion	782:797	methyl parathion	782:797	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	8	55	theme	lettuce	1682:1688	arg1	samples					1690:1696	lettuce samples	1682:1696	lettuce samples	1682:1696	Thus, the MSPE-HPLC-UV method has high accuracy and sensitivity for the analysis of methyl parathion and fenthion in lettuce samples.
34114573	1	56	theme	Fe3O4	139:143	arg1	β-cyclodextrin					150:163	magnetic Fe3O4@SiO2@β-cyclodextrin	130:163	magnetic Fe3O4@SiO2@β-cyclodextrin	130:163	In this study, magnetic Fe3O4@SiO2@β-cyclodextrin copolymerized microparticles were synthesized and applied for the extraction of methyl parathion and fenthion in lettuce samples followed by HPLC-UV detection.
34114573	6	57	theme	kg-1	1196:1199	arg1	ranges					1120:1125	Wide linear ranges	1108:1125	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion	1108:1226	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	5	58	from	detection	1053:1061	arg1	lettuce					1099:1105	lettuce	1099:1105	lettuce	1099:1105	Under the optimal extraction conditions, an MSPE-HPLC-UV method was developed for the detection of methyl parathion and fenthion in lettuce.
34114573	1	59	theme	SiO2	145:148	arg1	β-cyclodextrin					150:163	magnetic Fe3O4@SiO2@β-cyclodextrin	130:163	magnetic Fe3O4@SiO2@β-cyclodextrin	130:163	In this study, magnetic Fe3O4@SiO2@β-cyclodextrin copolymerized microparticles were synthesized and applied for the extraction of methyl parathion and fenthion in lettuce samples followed by HPLC-UV detection.
34114573	7	60	from	fenthion	1441:1448	arg1	lettuce					1453:1459	lettuce	1453:1459	lettuce with satisfactory recoveries between 89.2-101.2%	1453:1508	The proposed method was applied for the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%, and relative standard deviations were less than 9.1%.
34114573	6	61	theme	1.5-200	1185:1191	arg1	μg					1193:1194	μg	1193:1194	μg	1193:1194	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	7	62	from	lettuce	1453:1459	arg1	determination					1403:1415	the determination	1399:1415	the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%	1399:1508	The proposed method was applied for the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%, and relative standard deviations were less than 9.1%.
34114573	6	63	theme	0.5	1312:1314	arg1	μg					1316:1317	μg	1316:1317	μg	1316:1317	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	3	64	theme	X-ray	637:641	arg1	spectroscopy					623:634	spectroscopy	623:634	spectroscopy	623:634	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	3	64	theme	X-ray	637:641	arg1	diffraction					643:653	X-ray diffraction	637:653	X-ray diffraction	637:653	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	5	65	theme	optimal	977:983	arg1	conditions					996:1005	the optimal extraction conditions	973:1005	the optimal extraction conditions	973:1005	Under the optimal extraction conditions, an MSPE-HPLC-UV method was developed for the detection of methyl parathion and fenthion in lettuce.
34114573	3	66	dep	transform	604:612	arg1	infrared					614:621	infrared	614:621	transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis,	604:708	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	0	67	theme	methyl	65:70	arg1	parathion					72:80	methyl parathion	65:80	methyl parathion	65:80	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.
34114573	7	68	from	parathion	1427:1435	arg1	lettuce					1453:1459	lettuce	1453:1459	lettuce with satisfactory recoveries between 89.2-101.2%	1453:1508	The proposed method was applied for the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%, and relative standard deviations were less than 9.1%.
34114573	6	69	theme	μg	1138:1139	arg1	R2					1147:1148	R2 = 0.9998	1147:1157	R2 = 0.9998	1147:1157	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	6	69	theme	μg	1138:1139	arg1	kg-1					1141:1144	1.0-200 μg kg-1	1130:1144	1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion	1130:1179	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	6	69	theme	μg	1138:1139	arg1	R2					1202:1203	R2 = 0.9978	1202:1212	R2 = 0.9978	1202:1212	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	0	70	from	β-cyclodextrin	20:33	arg1	samples					106:112	lettuce samples	98:112	lettuce samples	98:112	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.
34114573	8	71	contain	has	1595:1597	arg2	sensitivity					1617:1627	sensitivity	1617:1627	sensitivity	1617:1627	Thus, the MSPE-HPLC-UV method has high accuracy and sensitivity for the analysis of methyl parathion and fenthion in lettuce samples.
34114573	8	71	contain	has	1595:1597	arg1	method					1588:1593	the MSPE-HPLC-UV method	1571:1593	the MSPE-HPLC-UV method	1571:1593	Thus, the MSPE-HPLC-UV method has high accuracy and sensitivity for the analysis of methyl parathion and fenthion in lettuce samples.
34114573	8	71	contain	has	1595:1597	arg2	accuracy					1604:1611	high accuracy	1599:1611	high accuracy	1599:1611	Thus, the MSPE-HPLC-UV method has high accuracy and sensitivity for the analysis of methyl parathion and fenthion in lettuce samples.
34114573	0	72	theme	Fe3O4	9:13	arg1	β-cyclodextrin					20:33	Magnetic Fe3O4@SiO2@β-cyclodextrin	0:33	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.	0:113	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.
34114573	2	73	theme	functional	461:470	arg1	monomer					472:478	the functional monomer	457:478	the functional monomer	457:478	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	2	73	theme	functional	461:470	arg1	microparticles					367:380	The magnetic β-cyclodextrin copolymerized microparticles	325:380	The magnetic β-cyclodextrin copolymerized microparticles	325:380	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	0	74	theme	SiO2	15:18	arg1	β-cyclodextrin					20:33	Magnetic Fe3O4@SiO2@β-cyclodextrin	0:33	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.	0:113	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.
34114573	6	75	theme	linear	1113:1118	arg1	ranges					1120:1125	Wide linear ranges	1108:1125	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion	1108:1226	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	3	76	used	used	714:717	arg2	microparticles					559:572	The composite magnetic microparticles	536:572	The composite magnetic microparticles	536:572	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	3	76	used	used	714:717	arg2	adsorbent					726:734	adsorbent	726:734	adsorbent	726:734	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	2	77	theme	acryloyl	430:437	arg1	β-cyclodextrin					439:452	acryloyl β-cyclodextrin	430:452	acryloyl β-cyclodextrin	430:452	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	5	78	theme	parathion	1073:1081	arg1	detection					1053:1061	the detection	1049:1061	the detection of methyl parathion and fenthion in lettuce	1049:1105	Under the optimal extraction conditions, an MSPE-HPLC-UV method was developed for the detection of methyl parathion and fenthion in lettuce.
34114573	0	79	theme	solid	39:43	arg1	extraction					51:60	solid phase extraction	39:60	solid phase extraction of methyl parathion and fenthion	39:93	Magnetic Fe3O4@SiO2@β-cyclodextrin for solid phase extraction of methyl parathion and fenthion in lettuce samples.
34114573	7	80	theme	standard	1524:1531	arg1	deviations					1533:1542	relative standard deviations	1515:1542	relative standard deviations	1515:1542	The proposed method was applied for the determination of methyl parathion and fenthion in lettuce with satisfactory recoveries between 89.2-101.2%, and relative standard deviations were less than 9.1%.
34114573	5	81	theme	fenthion	1087:1094	arg1	detection					1053:1061	the detection	1049:1061	the detection of methyl parathion and fenthion in lettuce	1049:1105	Under the optimal extraction conditions, an MSPE-HPLC-UV method was developed for the detection of methyl parathion and fenthion in lettuce.
34114573	6	82	theme	methyl	1164:1169	arg1	parathion					1171:1179	methyl parathion	1164:1179	methyl parathion	1164:1179	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	6	83	theme	μg	1316:1317	arg1	kg-1					1319:1322	0.5 μg kg-1	1312:1322	0.5 μg kg-1	1312:1322	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	4	84	theme	desorption	879:888	arg1	type					898:901	desorption solvent type	879:901	desorption solvent type	879:901	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	4	85	theme	sample	849:854	arg1	pH					856:857	sample pH	849:857	sample pH	849:857	The extraction conditions including sample pH and ionic strength, desorption solvent type and volume, and adsorption and desorption times were optimized.
34114573	8	86	theme	methyl	1649:1654	arg1	parathion					1656:1664	methyl parathion	1649:1664	methyl parathion	1649:1664	Thus, the MSPE-HPLC-UV method has high accuracy and sensitivity for the analysis of methyl parathion and fenthion in lettuce samples.
34114573	6	87	theme	=	1150:1150	arg1	R2					1147:1148	R2 = 0.9998	1147:1157	R2 = 0.9998	1147:1157	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	6	87	theme	=	1150:1150	arg1	kg-1					1141:1144	1.0-200 μg kg-1	1130:1144	1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion	1130:1179	Wide linear ranges of 1.0-200 μg kg-1 (R2 = 0.9998) for methyl parathion and 1.5-200 μg kg-1 (R2 = 0.9978) for fenthion were obtained and the limits of detection were 0.3 μg kg-1 for methyl parathion and 0.5 μg kg-1 for fenthion in lettuce, respectively.
34114573	8	88	theme	high	1599:1602	arg1	accuracy					1604:1611	high accuracy	1599:1611	high accuracy	1599:1611	Thus, the MSPE-HPLC-UV method has high accuracy and sensitivity for the analysis of methyl parathion and fenthion in lettuce samples.
34114573	3	89	theme	extraction	760:769	arg1	adsorbent					726:734	adsorbent	726:734	adsorbent	726:734	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	3	89	theme	extraction	760:769	arg1	microparticles					559:572	The composite magnetic microparticles	536:572	The composite magnetic microparticles	536:572	The composite magnetic microparticles were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, magnetic measurement, and thermogravimetric analysis, and used as the adsorbent of magnetic solid-phase extraction (MSPE) for methyl parathion and fenthion.
34114573	2	90	theme	copolymerized	353:365	arg1	monomer					472:478	the functional monomer	457:478	the functional monomer	457:478	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	2	90	theme	copolymerized	353:365	arg1	glycol					493:498	ethylene glycol	484:498	ethylene glycol	484:498	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
34114573	2	90	theme	copolymerized	353:365	arg1	microparticles					367:380	The magnetic β-cyclodextrin copolymerized microparticles	325:380	The magnetic β-cyclodextrin copolymerized microparticles	325:380	The magnetic β-cyclodextrin copolymerized microparticles were prepared by dispersion polymerization with acryloyl β-cyclodextrin as the functional monomer and ethylene glycol dimethyacrylate as the crosslinker.
32941910	12	0	contain	contained	1165:1173	arg2	content					1182:1188	higher content	1175:1188	higher content of total phenolics, flavonoids and tannin	1175:1230	RHP contained higher content of total phenolics, flavonoids and tannin, compared with RPP.
32941910	12	0	contain	contained	1165:1173	arg1	RHP					1161:1163	RHP	1161:1163	RHP	1161:1163	RHP contained higher content of total phenolics, flavonoids and tannin, compared with RPP.
32941910	7	1	theme	numerous	570:577	arg1	activities					590:599	numerous biological activities	570:599	numerous biological activities	570:599	is known as a traditional medicinal plant in which its various parts have been reported to exhibit antioxidant and numerous biological activities.
32941910	5	2	dep	Riang	418:422	arg1	timoriana					432:440	timoriana	432:440	timoriana	432:440	Riang (Parkia timoriana (DC.)
32941910	7	3	dep	plant	491:495	arg1	reported					534:541	reported	534:541	have been reported to exhibit antioxidant and numerous biological activities	524:599	is known as a traditional medicinal plant in which its various parts have been reported to exhibit antioxidant and numerous biological activities.
32941910	9	4	theme	dry	915:917	arg1	%					909:909	approximately 15 and 36%w/w	886:912	approximately 15 and 36%w/w (dry basis)	886:924	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	4	theme	dry	915:917	arg1	basis					919:923	dry basis	915:923	dry basis	915:923	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	0	5	theme	pectin	75:80	arg1	properties					61:70	antioxidant properties	49:70	antioxidant properties	49:70	Studies on chemical composition, rheological and antioxidant properties of pectin isolated from Riang (Parkia timoriana (DC.)
32941910	0	5	theme	pectin	75:80	arg1	composition					20:30	chemical composition	11:30	chemical composition	11:30	Studies on chemical composition, rheological and antioxidant properties of pectin isolated from Riang (Parkia timoriana (DC.)
32941910	4	6	theme	natural	375:381	arg1	compounds					395:403	natural antioxidant compounds	375:403	natural antioxidant compounds from plants	375:415	As a consequence, much research attention has been focused on developing natural antioxidant compounds from plants.
32941910	14	7	theme	antioxidant	1351:1361	arg1	activities					1363:1372	The highest antioxidant activities	1339:1372	The highest antioxidant activities	1339:1372	The highest antioxidant activities of RHP and RPP, obtained from ABTS assay, were 0.95 and 0.24 mmol Trolox equivalents/g, respectively.
32941910	14	7	theme	antioxidant	1351:1361	arg1	0.95					1421:1424	0.95	1421:1424	0.95	1421:1424	The highest antioxidant activities of RHP and RPP, obtained from ABTS assay, were 0.95 and 0.24 mmol Trolox equivalents/g, respectively.
32941910	0	8	dep	timoriana	110:118	arg1	DC					121:122	DC	121:122	Parkia timoriana (DC.	103:123	Studies on chemical composition, rheological and antioxidant properties of pectin isolated from Riang (Parkia timoriana (DC.)
32941910	8	9	theme	physico-chemical	686:701	arg1	properties					733:742	their physico-chemical, rheological, and antioxidant properties	680:742	their physico-chemical, rheological, and antioxidant properties	680:742	In this study, pectins from Riang pod husk and pod powder were extracted, and their physico-chemical, rheological, and antioxidant properties were characterized.
32941910	9	10	theme	high	830:833	arg1	200-250 kDa					853:863	200-250 kDa	853:863	200-250 kDa	853:863	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	10	theme	high	830:833	arg1	weight					845:850	high molecular weight	830:850	high molecular weight (200-250 kDa)	830:864	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	0	11	from	Studies	0:6	arg1	rheological					33:43	rheological	33:43	rheological	33:43	Studies on chemical composition, rheological and antioxidant properties of pectin isolated from Riang (Parkia timoriana (DC.)
32941910	0	11	from	Studies	0:6	arg1	properties					61:70	antioxidant properties	49:70	antioxidant properties	49:70	Studies on chemical composition, rheological and antioxidant properties of pectin isolated from Riang (Parkia timoriana (DC.)
32941910	0	11	from	Studies	0:6	arg1	composition					20:30	chemical composition	11:30	chemical composition	11:30	Studies on chemical composition, rheological and antioxidant properties of pectin isolated from Riang (Parkia timoriana (DC.)
32941910	14	12	theme	0.24 mmol	1430:1438	arg1	equivalents/g					1447:1459	0.24 mmol Trolox equivalents/g	1430:1459	0.24 mmol Trolox equivalents/g	1430:1459	The highest antioxidant activities of RHP and RPP, obtained from ABTS assay, were 0.95 and 0.24 mmol Trolox equivalents/g, respectively.
32941910	4	13	theme	research	325:332	arg1	attention					334:342	much research attention	320:342	much research attention	320:342	As a consequence, much research attention has been focused on developing natural antioxidant compounds from plants.
32941910	4	13	theme	research	325:332	arg1	consequence					307:317	a consequence	305:317	a consequence	305:317	As a consequence, much research attention has been focused on developing natural antioxidant compounds from plants.
32941910	7	14	theme	various	510:516	arg1	parts					518:522	its various parts	506:522	its various parts	506:522	is known as a traditional medicinal plant in which its various parts have been reported to exhibit antioxidant and numerous biological activities.
32941910	11	15	theme	Rheological	1088:1098	arg1	measurements					1100:1111	Rheological measurements	1088:1111	Rheological measurements	1088:1111	Rheological measurements revealed a pseudoplastic behavior above 2% w/v.
32941910	9	16	theme	molecular	835:843	arg1	200-250 kDa					853:863	200-250 kDa	853:863	200-250 kDa	853:863	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	16	theme	molecular	835:843	arg1	weight					845:850	high molecular weight	830:850	high molecular weight (200-250 kDa)	830:864	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	12	17	theme	tannin	1225:1230	arg1	content					1182:1188	higher content	1175:1188	higher content of total phenolics, flavonoids and tannin	1175:1230	RHP contained higher content of total phenolics, flavonoids and tannin, compared with RPP.
32941910	14	18	theme	highest	1343:1349	arg1	activities					1363:1372	The highest antioxidant activities	1339:1372	The highest antioxidant activities	1339:1372	The highest antioxidant activities of RHP and RPP, obtained from ABTS assay, were 0.95 and 0.24 mmol Trolox equivalents/g, respectively.
32941910	14	18	theme	highest	1343:1349	arg1	0.95					1421:1424	0.95	1421:1424	0.95	1421:1424	The highest antioxidant activities of RHP and RPP, obtained from ABTS assay, were 0.95 and 0.24 mmol Trolox equivalents/g, respectively.
32941910	12	19	theme	total	1193:1197	arg1	phenolics					1199:1207	total phenolics	1193:1207	total phenolics	1193:1207	RHP contained higher content of total phenolics, flavonoids and tannin, compared with RPP.
32941910	8	20	theme	rheological	704:714	arg1	properties					733:742	their physico-chemical, rheological, and antioxidant properties	680:742	their physico-chemical, rheological, and antioxidant properties	680:742	In this study, pectins from Riang pod husk and pod powder were extracted, and their physico-chemical, rheological, and antioxidant properties were characterized.
32941910	3	21	theme	human	288:292	arg1	health					294:299	human health	288:299	human health	288:299	Although synthetic antioxidant food additives are widely used in a variety of food products, some of them are suspected of having a noxious effect on human health.
32941910	3	22	theme	food	216:219	arg1	products					221:228	food products	216:228	food products	216:228	Although synthetic antioxidant food additives are widely used in a variety of food products, some of them are suspected of having a noxious effect on human health.
32941910	9	23	theme	powder	969:974	arg1	RPP					984:986	RPP	984:986	RPP	984:986	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	23	theme	powder	969:974	arg1	pectin					976:981	Riang pod powder pectin	959:981	Riang pod powder pectin (RPP)	959:987	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	12	24	theme	flavonoids	1210:1219	arg1	content					1182:1188	higher content	1175:1188	higher content of total phenolics, flavonoids and tannin	1175:1230	RHP contained higher content of total phenolics, flavonoids and tannin, compared with RPP.
32941910	10	25	theme	%	1085:1085	arg1	DE					1076:1077	their DE	1070:1077	their DE of ~66%	1070:1085	Furthermore, both pectins were classified as a high methoxyl with their DE of ~66%.
32941910	3	26	theme	products	221:228	arg1	variety					205:211	a variety	203:211	a variety of food products	203:228	Although synthetic antioxidant food additives are widely used in a variety of food products, some of them are suspected of having a noxious effect on human health.
32941910	3	26	theme	products	221:228	arg1	products					221:228	food products	216:228	food products	216:228	Although synthetic antioxidant food additives are widely used in a variety of food products, some of them are suspected of having a noxious effect on human health.
32941910	9	27	theme	Riang	931:935	arg1	RHP					950:952	RHP	950:952	RHP	950:952	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	27	theme	Riang	931:935	arg1	pectin					942:947	Riang husk pectin	931:947	Riang husk pectin (RHP)	931:953	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	3	28	theme	noxious	270:276	arg1	effect					278:283	a noxious effect	268:283	a noxious effect on human health	268:299	Although synthetic antioxidant food additives are widely used in a variety of food products, some of them are suspected of having a noxious effect on human health.
32941910	8	29	from	pod	649:651	arg1	pectins					617:623	pectins	617:623	pectins from Riang pod husk and pod powder	617:658	In this study, pectins from Riang pod husk and pod powder were extracted, and their physico-chemical, rheological, and antioxidant properties were characterized.
32941910	14	30	theme	ABTS	1404:1407	arg1	assay					1409:1413	ABTS assay	1404:1413	ABTS assay	1404:1413	The highest antioxidant activities of RHP and RPP, obtained from ABTS assay, were 0.95 and 0.24 mmol Trolox equivalents/g, respectively.
32941910	12	31	theme	higher	1175:1180	arg1	content					1182:1188	higher content	1175:1188	higher content of total phenolics, flavonoids and tannin	1175:1230	RHP contained higher content of total phenolics, flavonoids and tannin, compared with RPP.
32941910	9	32	theme	husk	937:940	arg1	RHP					950:952	RHP	950:952	RHP	950:952	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	32	theme	husk	937:940	arg1	pectin					942:947	Riang husk pectin	931:947	Riang husk pectin (RHP)	931:953	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	8	33	theme	Riang	630:634	arg1	pod					636:638	Riang pod husk and pod powder	630:658	pod	636:638	In this study, pectins from Riang pod husk and pod powder were extracted, and their physico-chemical, rheological, and antioxidant properties were characterized.
32941910	9	34	theme	extracted	768:776	arg1	pectins					778:784	The extracted pectins	764:784	The extracted pectins	764:784	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	4	35	theme	much	320:323	arg1	attention					334:342	much research attention	320:342	much research attention	320:342	As a consequence, much research attention has been focused on developing natural antioxidant compounds from plants.
32941910	4	35	theme	much	320:323	arg1	consequence					307:317	a consequence	305:317	a consequence	305:317	As a consequence, much research attention has been focused on developing natural antioxidant compounds from plants.
32941910	8	36	from	pod	636:638	arg1	pectins					617:623	pectins	617:623	pectins from Riang pod husk and pod powder	617:658	In this study, pectins from Riang pod husk and pod powder were extracted, and their physico-chemical, rheological, and antioxidant properties were characterized.
32941910	7	37	theme	biological	579:588	arg1	activities					590:599	numerous biological activities	570:599	numerous biological activities	570:599	is known as a traditional medicinal plant in which its various parts have been reported to exhibit antioxidant and numerous biological activities.
32941910	3	38	theme	antioxidant	157:167	arg1	additives					174:182	synthetic antioxidant food additives	147:182	synthetic antioxidant food additives	147:182	Although synthetic antioxidant food additives are widely used in a variety of food products, some of them are suspected of having a noxious effect on human health.
32941910	4	39	from	plants	410:415	arg1	compounds					395:403	natural antioxidant compounds	375:403	natural antioxidant compounds from plants	375:415	As a consequence, much research attention has been focused on developing natural antioxidant compounds from plants.
32941910	3	40	theme	food	169:172	arg1	additives					174:182	synthetic antioxidant food additives	147:182	synthetic antioxidant food additives	147:182	Although synthetic antioxidant food additives are widely used in a variety of food products, some of them are suspected of having a noxious effect on human health.
32941910	7	41	theme	traditional	469:479	arg1	plant					491:495	a traditional medicinal plant	467:495	a traditional medicinal plant in which its various parts have been reported to exhibit antioxidant and numerous biological activities	467:599	is known as a traditional medicinal plant in which its various parts have been reported to exhibit antioxidant and numerous biological activities.
32941910	0	42	theme	chemical	11:18	arg1	composition					20:30	chemical composition	11:30	chemical composition	11:30	Studies on chemical composition, rheological and antioxidant properties of pectin isolated from Riang (Parkia timoriana (DC.)
32941910	7	43	theme	medicinal	481:489	arg1	plant					491:495	a traditional medicinal plant	467:495	a traditional medicinal plant in which its various parts have been reported to exhibit antioxidant and numerous biological activities	467:599	is known as a traditional medicinal plant in which its various parts have been reported to exhibit antioxidant and numerous biological activities.
32941910	9	44	theme	high	793:796	arg1	content					810:816	high uronic acid content	793:816	high uronic acid content (> 65%)	793:824	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	44	theme	high	793:796	arg1	%					823:823	> 65%	819:823	> 65%	819:823	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	4	45	theme	antioxidant	383:393	arg1	compounds					395:403	natural antioxidant compounds	375:403	natural antioxidant compounds from plants	375:415	As a consequence, much research attention has been focused on developing natural antioxidant compounds from plants.
32941910	13	46	theme	RHP	1278:1280	arg1	activities					1264:1273	Antioxidant activities	1252:1273	Antioxidant activities of RHP	1252:1280	Antioxidant activities of RHP were consequently higher than RPP in all studied assays.
32941910	10	47	theme	high	1051:1054	arg1	pectins					1022:1028	both pectins	1017:1028	both pectins	1017:1028	Furthermore, both pectins were classified as a high methoxyl with their DE of ~66%.
32941910	10	47	theme	high	1051:1054	arg1	methoxyl					1056:1063	a high methoxyl	1049:1063	a high methoxyl with their DE of ~66%	1049:1085	Furthermore, both pectins were classified as a high methoxyl with their DE of ~66%.
32941910	9	48	theme	uronic	798:803	arg1	content					810:816	high uronic acid content	793:816	high uronic acid content (> 65%)	793:824	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	48	theme	uronic	798:803	arg1	%					823:823	> 65%	819:823	> 65%	819:823	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	11	49	theme	pseudoplastic	1124:1136	arg1	behavior					1138:1145	a pseudoplastic behavior	1122:1145	a pseudoplastic behavior above 2% w/v	1122:1158	Rheological measurements revealed a pseudoplastic behavior above 2% w/v.
32941910	0	50	theme	antioxidant	49:59	arg1	properties					61:70	antioxidant properties	49:70	antioxidant properties	49:70	Studies on chemical composition, rheological and antioxidant properties of pectin isolated from Riang (Parkia timoriana (DC.)
32941910	9	51	theme	acid	805:808	arg1	content					810:816	high uronic acid content	793:816	high uronic acid content (> 65%)	793:824	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	51	theme	acid	805:808	arg1	%					823:823	> 65%	819:823	> 65%	819:823	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	13	52	theme	Antioxidant	1252:1262	arg1	activities					1264:1273	Antioxidant activities	1252:1273	Antioxidant activities of RHP	1252:1280	Antioxidant activities of RHP were consequently higher than RPP in all studied assays.
32941910	9	53	theme	Riang	959:963	arg1	RPP					984:986	RPP	984:986	RPP	984:986	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	53	theme	Riang	959:963	arg1	pectin					976:981	Riang pod powder pectin	959:981	Riang pod powder pectin (RPP)	959:987	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	7	54	dep	which	500:504	arg1	in					497:498	in	497:498	in	497:498	is known as a traditional medicinal plant in which its various parts have been reported to exhibit antioxidant and numerous biological activities.
32941910	10	55	with	methoxyl	1056:1063	arg1	DE					1076:1077	their DE	1070:1077	their DE of ~66%	1070:1085	Furthermore, both pectins were classified as a high methoxyl with their DE of ~66%.
32941910	9	56	theme	pod	965:967	arg1	RPP					984:986	RPP	984:986	RPP	984:986	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	56	theme	pod	965:967	arg1	pectin					976:981	Riang pod powder pectin	959:981	Riang pod powder pectin (RPP)	959:987	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	8	57	theme	antioxidant	721:731	arg1	properties					733:742	their physico-chemical, rheological, and antioxidant properties	680:742	their physico-chemical, rheological, and antioxidant properties	680:742	In this study, pectins from Riang pod husk and pod powder were extracted, and their physico-chemical, rheological, and antioxidant properties were characterized.
32941910	8	58	dep	pod	636:638	arg1	husk					640:643	husk	640:643	husk	640:643	In this study, pectins from Riang pod husk and pod powder were extracted, and their physico-chemical, rheological, and antioxidant properties were characterized.
32941910	8	58	dep	pod	636:638	arg1	powder					653:658	powder	653:658	powder	653:658	In this study, pectins from Riang pod husk and pod powder were extracted, and their physico-chemical, rheological, and antioxidant properties were characterized.
32941910	3	59	theme	synthetic	147:155	arg1	additives					174:182	synthetic antioxidant food additives	147:182	synthetic antioxidant food additives	147:182	Although synthetic antioxidant food additives are widely used in a variety of food products, some of them are suspected of having a noxious effect on human health.
32941910	0	60	attach	isolated	82:89	arg2	Studies					0:6	Studies	0:6	Studies on chemical composition, rheological and antioxidant properties of pectin isolated from Riang (Parkia timoriana (DC.)	0:124	Studies on chemical composition, rheological and antioxidant properties of pectin isolated from Riang (Parkia timoriana (DC.)
32941910	0	60	attach	isolated	82:89	arg1	timoriana					110:118	timoriana	110:118	timoriana	110:118	Studies on chemical composition, rheological and antioxidant properties of pectin isolated from Riang (Parkia timoriana (DC.)
32941910	0	60	attach	isolated	82:89	arg1	Riang					96:100	Riang	96:100	Riang	96:100	Studies on chemical composition, rheological and antioxidant properties of pectin isolated from Riang (Parkia timoriana (DC.)
32941910	3	61	from	effect	278:283	arg1	health					294:299	human health	288:299	human health	288:299	Although synthetic antioxidant food additives are widely used in a variety of food products, some of them are suspected of having a noxious effect on human health.
32941910	12	62	theme	phenolics	1199:1207	arg1	content					1182:1188	higher content	1175:1188	higher content of total phenolics, flavonoids and tannin	1175:1230	RHP contained higher content of total phenolics, flavonoids and tannin, compared with RPP.
32941910	9	63	theme	>	819:819	arg1	content					810:816	high uronic acid content	793:816	high uronic acid content (> 65%)	793:824	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	63	theme	>	819:819	arg1	%					823:823	> 65%	819:823	> 65%	819:823	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	3	64	used	used	195:198	arg2	additives					174:182	synthetic antioxidant food additives	147:182	synthetic antioxidant food additives	147:182	Although synthetic antioxidant food additives are widely used in a variety of food products, some of them are suspected of having a noxious effect on human health.
32941910	13	65	theme	studied	1323:1329	arg1	assays					1331:1336	all studied assays	1319:1336	all studied assays	1319:1336	Antioxidant activities of RHP were consequently higher than RPP in all studied assays.
32941910	14	66	theme	RHP	1377:1379	arg1	activities					1363:1372	The highest antioxidant activities	1339:1372	The highest antioxidant activities	1339:1372	The highest antioxidant activities of RHP and RPP, obtained from ABTS assay, were 0.95 and 0.24 mmol Trolox equivalents/g, respectively.
32941910	14	66	theme	RHP	1377:1379	arg1	0.95					1421:1424	0.95	1421:1424	0.95	1421:1424	The highest antioxidant activities of RHP and RPP, obtained from ABTS assay, were 0.95 and 0.24 mmol Trolox equivalents/g, respectively.
32941910	9	67	theme	w/w	910:912	arg1	%					909:909	approximately 15 and 36%w/w	886:912	approximately 15 and 36%w/w (dry basis)	886:924	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	67	theme	w/w	910:912	arg1	basis					919:923	dry basis	915:923	dry basis	915:923	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	9	67	theme	w/w	910:912	arg1	yields					874:879	the yields	870:879	the yields	870:879	The extracted pectins showed high uronic acid content (> 65%) and high molecular weight (200-250 kDa) and the yields were approximately 15 and 36%w/w (dry basis), for Riang husk pectin (RHP) and Riang pod powder pectin (RPP), respectively.
32941910	11	68	theme	%	1154:1154	arg1	w/v					1156:1158	2% w/v	1153:1158	2% w/v	1153:1158	Rheological measurements revealed a pseudoplastic behavior above 2% w/v.
32941910	14	69	theme	Trolox	1440:1445	arg1	equivalents/g					1447:1459	0.24 mmol Trolox equivalents/g	1430:1459	0.24 mmol Trolox equivalents/g	1430:1459	The highest antioxidant activities of RHP and RPP, obtained from ABTS assay, were 0.95 and 0.24 mmol Trolox equivalents/g, respectively.
32941910	14	70	theme	RPP	1385:1387	arg1	activities					1363:1372	The highest antioxidant activities	1339:1372	The highest antioxidant activities	1339:1372	The highest antioxidant activities of RHP and RPP, obtained from ABTS assay, were 0.95 and 0.24 mmol Trolox equivalents/g, respectively.
32941910	14	70	theme	RPP	1385:1387	arg1	0.95					1421:1424	0.95	1421:1424	0.95	1421:1424	The highest antioxidant activities of RHP and RPP, obtained from ABTS assay, were 0.95 and 0.24 mmol Trolox equivalents/g, respectively.
32600090	0	0	theme	cartilage	113:121	arg1	repair					123:128	articular cartilage repair	103:128	articular cartilage repair	103:128	Wet-electrospun PHBV nanofiber reinforced carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair.
32600090	2	1	theme	glycol	566:571	arg1	PEGDE					592:596	PEGDE	592:596	PEGDE	592:596	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	2	1	theme	glycol	566:571	arg1	ether					585:589	poly(ethylene glycol) diglycidyl ether	552:589	poly(ethylene glycol) diglycidyl ether (PEGDE)	552:597	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	4	2	theme	PHBV	953:956	arg1	nanofibers					958:967	well-integrated PHBV nanofibers	937:967	well-integrated PHBV nanofibers	937:967	All of the produced hydrogel composite scaffolds had an interconnected microporous structure with well-integrated PHBV nanofibers on the pore walls.
32600090	1	3	theme	three-dimensional	173:189	arg1	scaffolds					232:240	three-dimensional and porous nanofiber reinforced hydrogel scaffolds	173:240	three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix	173:326	The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix.
32600090	4	4	with	structure	922:930	arg1	nanofibers					958:967	well-integrated PHBV nanofibers	937:967	well-integrated PHBV nanofibers	937:967	All of the produced hydrogel composite scaffolds had an interconnected microporous structure with well-integrated PHBV nanofibers on the pore walls.
32600090	4	5	contain	had	888:890	arg1	scaffolds					878:886	the produced hydrogel composite scaffolds	846:886	the produced hydrogel composite scaffolds	846:886	All of the produced hydrogel composite scaffolds had an interconnected microporous structure with well-integrated PHBV nanofibers on the pore walls.
32600090	4	5	contain	had	888:890	arg2	structure					922:930	an interconnected microporous structure	892:930	an interconnected microporous structure with well-integrated PHBV nanofibers	892:967	All of the produced hydrogel composite scaffolds had an interconnected microporous structure with well-integrated PHBV nanofibers on the pore walls.
32600090	4	5	contain	had	888:890	arg1	All					839:841	All	839:841	All	839:841	All of the produced hydrogel composite scaffolds had an interconnected microporous structure with well-integrated PHBV nanofibers on the pore walls.
32600090	0	6	theme	articular	103:111	arg1	repair					123:128	articular cartilage repair	103:128	articular cartilage repair	103:128	Wet-electrospun PHBV nanofiber reinforced carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair.
32600090	3	7	theme	composite	734:742	arg1	scaffold					744:751	a three dimensional porous spongy composite scaffold	700:751	a three dimensional porous spongy composite scaffold	700:751	To the best of our knowledge, this is the first study in cartilage regeneration where a three dimensional porous spongy composite scaffold was obtained by the dispersion of wet-electrospun nanofibers within a polymer matrix.
32600090	2	8	dep	cross-linked	536:547	arg1	produced					604:611	produced	604:611	were produced	599:611	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	5	9	theme	457 ± 85 kPa	1174:1185	arg1	values					1188:1193	compressive strength (457 ± 85 kPa) values	1152:1193	compressive strength (457 ± 85 kPa) values	1152:1193	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	1	10	theme	cartilage	297:305	arg1	matrix					321:326	the cartilage extracellular matrix	293:326	the cartilage extracellular matrix	293:326	The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix.
32600090	7	11	theme	cartilage	1464:1472	arg1	regeneration					1481:1492	cartilage tissue regeneration	1464:1492	cartilage tissue regeneration	1464:1492	Consequently, this hydrogel composite scaffold presented a great promise for cartilage tissue regeneration.
32600090	5	12	theme	polymer	1041:1047	arg1	polymer					1041:1047	polymer	1041:1047	polymer (PNFs/CMCht-SF1:PEGDE1)	1041:1071	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	5	12	theme	polymer	1041:1047	arg1	PEGDE					1031:1035	PEGDE	1031:1035	PEGDE	1031:1035	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	5	12	theme	polymer	1041:1047	arg1	amount					1021:1026	an equal amount	1012:1026	an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1)	1012:1071	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	5	12	theme	polymer	1041:1047	arg1	PNFs/CMCht-SF1					1050:1063	PNFs/CMCht-SF1	1050:1063	PNFs/CMCht-SF1:PEGDE1	1050:1070	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	6	13	theme	mesenchymal	1363:1373	arg1	cells					1380:1384	bone marrow mesenchymal stem cells	1351:1384	bone marrow mesenchymal stem cells	1351:1384	Besides, based on the histological analysis, this hydrogel composite scaffold supported the chondrogenic differentiation of bone marrow mesenchymal stem cells.
32600090	1	14	theme	extracellular	307:319	arg1	matrix					321:326	the cartilage extracellular matrix	293:326	the cartilage extracellular matrix	293:326	The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix.
32600090	4	15	theme	microporous	910:920	arg1	structure					922:930	an interconnected microporous structure	892:930	an interconnected microporous structure with well-integrated PHBV nanofibers	892:967	All of the produced hydrogel composite scaffolds had an interconnected microporous structure with well-integrated PHBV nanofibers on the pore walls.
32600090	1	16	theme	reinforced	212:221	arg1	scaffolds					232:240	three-dimensional and porous nanofiber reinforced hydrogel scaffolds	173:240	three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix	173:326	The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix.
32600090	1	17	theme	porous	195:200	arg1	scaffolds					232:240	three-dimensional and porous nanofiber reinforced hydrogel scaffolds	173:240	three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix	173:326	The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix.
32600090	4	18	theme	interconnected	895:908	arg1	structure					922:930	an interconnected microporous structure	892:930	an interconnected microporous structure with well-integrated PHBV nanofibers	892:967	All of the produced hydrogel composite scaffolds had an interconnected microporous structure with well-integrated PHBV nanofibers on the pore walls.
32600090	2	19	dep	nanofiber	413:421	arg1	reinforced					423:432	reinforced	423:432	nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced	413:611	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	3	20	from	study	662:666	arg1	regeneration					681:692	cartilage regeneration	671:692	cartilage regeneration	671:692	To the best of our knowledge, this is the first study in cartilage regeneration where a three dimensional porous spongy composite scaffold was obtained by the dispersion of wet-electrospun nanofibers within a polymer matrix.
32600090	1	21	theme	nanofiber	202:210	arg1	scaffolds					232:240	three-dimensional and porous nanofiber reinforced hydrogel scaffolds	173:240	three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix	173:326	The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix.
32600090	0	22	theme	PHBV	16:19	arg1	nanofiber					21:29	Wet-electrospun PHBV nanofiber	0:29	Wet-electrospun PHBV nanofiber	0:29	Wet-electrospun PHBV nanofiber reinforced carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair.
32600090	2	23	theme	ethylene	557:564	arg1	PEGDE					592:596	PEGDE	592:596	PEGDE	592:596	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	2	23	theme	ethylene	557:564	arg1	ether					585:589	poly(ethylene glycol) diglycidyl ether	552:589	poly(ethylene glycol) diglycidyl ether (PEGDE)	552:597	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	6	24	theme	hydrogel	1277:1284	arg1	scaffold					1296:1303	this hydrogel composite scaffold	1272:1303	this hydrogel composite scaffold	1272:1303	Besides, based on the histological analysis, this hydrogel composite scaffold supported the chondrogenic differentiation of bone marrow mesenchymal stem cells.
32600090	5	25	theme	equal	1015:1019	arg1	polymer					1041:1047	polymer	1041:1047	polymer (PNFs/CMCht-SF1:PEGDE1)	1041:1071	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	5	25	theme	equal	1015:1019	arg1	PEGDE					1031:1035	PEGDE	1031:1035	PEGDE	1031:1035	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	5	25	theme	equal	1015:1019	arg1	amount					1021:1026	an equal amount	1012:1026	an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1)	1012:1071	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	5	25	theme	equal	1015:1019	arg1	PNFs/CMCht-SF1					1050:1063	PNFs/CMCht-SF1	1050:1063	PNFs/CMCht-SF1:PEGDE1	1050:1070	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	2	26	theme	chitosan-silk	448:460	arg1	scaffolds					505:513	carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds	434:513	carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced	434:611	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	0	27	theme	Wet-electrospun	0:14	arg1	nanofiber					21:29	Wet-electrospun PHBV nanofiber	0:29	Wet-electrospun PHBV nanofiber	0:29	Wet-electrospun PHBV nanofiber reinforced carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair.
32600090	1	28	theme	matrix	321:326	arg1	structure					280:288	the hydrated composite structure	257:288	the hydrated composite structure of the cartilage extracellular matrix	257:326	The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix.
32600090	2	29	theme	wet-electrospun	345:359	arg1	3-hydroxybutyrate-co-3-hydroxyvalerate					366:403	3-hydroxybutyrate-co-3-hydroxyvalerate	366:403	3-hydroxybutyrate-co-3-hydroxyvalerate	366:403	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	2	29	theme	wet-electrospun	345:359	arg1	PHBV					407:410	PHBV	407:410	PHBV	407:410	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	2	29	theme	wet-electrospun	345:359	arg1	poly					361:364	wet-electrospun poly	345:364	wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)	345:411	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	1	30	theme	hydrogel	223:230	arg1	scaffolds					232:240	three-dimensional and porous nanofiber reinforced hydrogel scaffolds	173:240	three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix	173:326	The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix.
32600090	5	31	theme	articular	1206:1214	arg1	cartilage					1216:1224	articular cartilage	1206:1224	articular cartilage	1206:1224	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	6	32	theme	chondrogenic	1319:1330	arg1	differentiation					1332:1346	the chondrogenic differentiation	1315:1346	the chondrogenic differentiation of bone marrow mesenchymal stem cells	1315:1384	Besides, based on the histological analysis, this hydrogel composite scaffold supported the chondrogenic differentiation of bone marrow mesenchymal stem cells.
32600090	4	33	theme	well-integrated	937:951	arg1	nanofibers					958:967	well-integrated PHBV nanofibers	937:967	well-integrated PHBV nanofibers	937:967	All of the produced hydrogel composite scaffolds had an interconnected microporous structure with well-integrated PHBV nanofibers on the pore walls.
32600090	2	34	theme	composite	495:503	arg1	scaffolds					505:513	carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds	434:513	carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced	434:611	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	7	35	theme	tissue	1474:1479	arg1	regeneration					1481:1492	cartilage tissue regeneration	1464:1492	cartilage tissue regeneration	1464:1492	Consequently, this hydrogel composite scaffold presented a great promise for cartilage tissue regeneration.
32600090	3	36	theme	wet-electrospun	787:801	arg1	nanofibers					803:812	wet-electrospun nanofibers	787:812	wet-electrospun nanofibers	787:812	To the best of our knowledge, this is the first study in cartilage regeneration where a three dimensional porous spongy composite scaffold was obtained by the dispersion of wet-electrospun nanofibers within a polymer matrix.
32600090	5	37	theme	tan	1126:1128	arg1	δ					1130:1130	tan δ	1126:1130	tan δ (0.183 at 1 Hz)	1126:1146	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	5	38	theme	PEGDE	1031:1035	arg1	polymer					1041:1047	polymer	1041:1047	polymer (PNFs/CMCht-SF1:PEGDE1)	1041:1071	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	5	38	theme	PEGDE	1031:1035	arg1	PEGDE					1031:1035	PEGDE	1031:1035	PEGDE	1031:1035	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	5	38	theme	PEGDE	1031:1035	arg1	amount					1021:1026	an equal amount	1012:1026	an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1)	1012:1071	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	5	38	theme	PEGDE	1031:1035	arg1	PNFs/CMCht-SF1					1050:1063	PNFs/CMCht-SF1	1050:1063	PNFs/CMCht-SF1:PEGDE1	1050:1070	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	2	39	theme	hydrogel	486:493	arg1	scaffolds					505:513	carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds	434:513	carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced	434:611	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	0	40	theme	chitosan-silk	56:68	arg1	scaffolds					89:97	carboxymethyl chitosan-silk hydrogel composite scaffolds	42:97	carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair	42:128	Wet-electrospun PHBV nanofiber reinforced carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair.
32600090	3	41	theme	nanofibers	803:812	arg1	dispersion					773:782	the dispersion	769:782	the dispersion of wet-electrospun nanofibers within a polymer matrix	769:836	To the best of our knowledge, this is the first study in cartilage regeneration where a three dimensional porous spongy composite scaffold was obtained by the dispersion of wet-electrospun nanofibers within a polymer matrix.
32600090	6	42	theme	cells	1380:1384	arg1	differentiation					1332:1346	the chondrogenic differentiation	1315:1346	the chondrogenic differentiation of bone marrow mesenchymal stem cells	1315:1384	Besides, based on the histological analysis, this hydrogel composite scaffold supported the chondrogenic differentiation of bone marrow mesenchymal stem cells.
32600090	5	43	theme	comparable	1086:1095	arg1	content					1103:1109	comparable water content	1086:1109	comparable water content (91.4 ± 0.7%)	1086:1123	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	5	43	theme	comparable	1086:1095	arg1	%					1122:1122	91.4 ± 0.7%	1112:1122	91.4 ± 0.7%	1112:1122	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	2	44	theme	carboxymethyl	434:446	arg1	scaffolds					505:513	carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds	434:513	carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced	434:611	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	0	45	theme	carboxymethyl	42:54	arg1	scaffolds					89:97	carboxymethyl chitosan-silk hydrogel composite scaffolds	42:97	carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair	42:128	Wet-electrospun PHBV nanofiber reinforced carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair.
32600090	2	46	theme	poly	552:555	arg1	PEGDE					592:596	PEGDE	592:596	PEGDE	592:596	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	2	46	theme	poly	552:555	arg1	ether					585:589	poly(ethylene glycol) diglycidyl ether	552:589	poly(ethylene glycol) diglycidyl ether (PEGDE)	552:597	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	3	47	theme	cartilage	671:679	arg1	regeneration					681:692	cartilage regeneration	671:692	cartilage regeneration	671:692	To the best of our knowledge, this is the first study in cartilage regeneration where a three dimensional porous spongy composite scaffold was obtained by the dispersion of wet-electrospun nanofibers within a polymer matrix.
32600090	4	48	theme	composite	868:876	arg1	scaffolds					878:886	the produced hydrogel composite scaffolds	846:886	the produced hydrogel composite scaffolds	846:886	All of the produced hydrogel composite scaffolds had an interconnected microporous structure with well-integrated PHBV nanofibers on the pore walls.
32600090	2	49	theme	PNFs/CMCht-SF	471:483	arg1	scaffolds					505:513	carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds	434:513	carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced	434:611	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	0	50	theme	composite	79:87	arg1	scaffolds					89:97	carboxymethyl chitosan-silk hydrogel composite scaffolds	42:97	carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair	42:128	Wet-electrospun PHBV nanofiber reinforced carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair.
32600090	5	51	theme	strength	1164:1171	arg1	values					1188:1193	compressive strength (457 ± 85 kPa) values	1152:1193	compressive strength (457 ± 85 kPa) values	1152:1193	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	4	52	theme	pore	976:979	arg1	walls					981:985	the pore walls	972:985	the pore walls	972:985	All of the produced hydrogel composite scaffolds had an interconnected microporous structure with well-integrated PHBV nanofibers on the pore walls.
32600090	7	53	theme	great	1446:1450	arg1	promise					1452:1458	a great promise	1444:1458	a great promise for cartilage tissue regeneration	1444:1492	Consequently, this hydrogel composite scaffold presented a great promise for cartilage tissue regeneration.
32600090	6	54	theme	histological	1249:1260	arg1	analysis					1262:1269	the histological analysis	1245:1269	the histological analysis	1245:1269	Besides, based on the histological analysis, this hydrogel composite scaffold supported the chondrogenic differentiation of bone marrow mesenchymal stem cells.
32600090	0	55	theme	hydrogel	70:77	arg1	scaffolds					89:97	carboxymethyl chitosan-silk hydrogel composite scaffolds	42:97	carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair	42:128	Wet-electrospun PHBV nanofiber reinforced carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair.
32600090	3	56	theme	polymer	823:829	arg1	matrix					831:836	a polymer matrix	821:836	a polymer matrix	821:836	To the best of our knowledge, this is the first study in cartilage regeneration where a three dimensional porous spongy composite scaffold was obtained by the dispersion of wet-electrospun nanofibers within a polymer matrix.
32600090	6	57	theme	marrow	1356:1361	arg1	cells					1380:1384	bone marrow mesenchymal stem cells	1351:1384	bone marrow mesenchymal stem cells	1351:1384	Besides, based on the histological analysis, this hydrogel composite scaffold supported the chondrogenic differentiation of bone marrow mesenchymal stem cells.
32600090	3	58	theme	porous	720:725	arg1	scaffold					744:751	a three dimensional porous spongy composite scaffold	700:751	a three dimensional porous spongy composite scaffold	700:751	To the best of our knowledge, this is the first study in cartilage regeneration where a three dimensional porous spongy composite scaffold was obtained by the dispersion of wet-electrospun nanofibers within a polymer matrix.
32600090	6	59	theme	composite	1286:1294	arg1	scaffold					1296:1303	this hydrogel composite scaffold	1272:1303	this hydrogel composite scaffold	1272:1303	Besides, based on the histological analysis, this hydrogel composite scaffold supported the chondrogenic differentiation of bone marrow mesenchymal stem cells.
32600090	5	60	dep	PNFs/CMCht-SF1	1050:1063	arg1	PEGDE1					1065:1070	PEGDE1	1065:1070	PNFs/CMCht-SF1:PEGDE1	1050:1070	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	4	61	theme	produced	850:857	arg1	scaffolds					878:886	the produced hydrogel composite scaffolds	846:886	the produced hydrogel composite scaffolds	846:886	All of the produced hydrogel composite scaffolds had an interconnected microporous structure with well-integrated PHBV nanofibers on the pore walls.
32600090	6	62	theme	bone	1351:1354	arg1	cells					1380:1384	bone marrow mesenchymal stem cells	1351:1384	bone marrow mesenchymal stem cells	1351:1384	Besides, based on the histological analysis, this hydrogel composite scaffold supported the chondrogenic differentiation of bone marrow mesenchymal stem cells.
32600090	3	63	theme	spongy	727:732	arg1	scaffold					744:751	a three dimensional porous spongy composite scaffold	700:751	a three dimensional porous spongy composite scaffold	700:751	To the best of our knowledge, this is the first study in cartilage regeneration where a three dimensional porous spongy composite scaffold was obtained by the dispersion of wet-electrospun nanofibers within a polymer matrix.
32600090	7	64	theme	hydrogel	1406:1413	arg1	scaffold					1425:1432	this hydrogel composite scaffold	1401:1432	this hydrogel composite scaffold	1401:1432	Consequently, this hydrogel composite scaffold presented a great promise for cartilage tissue regeneration.
32600090	5	65	theme	water	1097:1101	arg1	content					1103:1109	comparable water content	1086:1109	comparable water content (91.4 ± 0.7%)	1086:1123	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	5	65	theme	water	1097:1101	arg1	%					1122:1122	91.4 ± 0.7%	1112:1122	91.4 ± 0.7%	1112:1122	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	1	66	theme	study	152:156	arg1	objective					135:143	The objective	131:143	The objective of the study	131:156	The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix.
32600090	6	67	theme	stem	1375:1378	arg1	cells					1380:1384	bone marrow mesenchymal stem cells	1351:1384	bone marrow mesenchymal stem cells	1351:1384	Besides, based on the histological analysis, this hydrogel composite scaffold supported the chondrogenic differentiation of bone marrow mesenchymal stem cells.
32600090	7	68	theme	composite	1415:1423	arg1	scaffold					1425:1432	this hydrogel composite scaffold	1401:1432	this hydrogel composite scaffold	1401:1432	Consequently, this hydrogel composite scaffold presented a great promise for cartilage tissue regeneration.
32600090	1	69	theme	hydrated	261:268	arg1	structure					280:288	the hydrated composite structure	257:288	the hydrated composite structure of the cartilage extracellular matrix	257:326	The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix.
32600090	2	70	theme	diglycidyl	574:583	arg1	PEGDE					592:596	PEGDE	592:596	PEGDE	592:596	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	2	70	theme	diglycidyl	574:583	arg1	ether					585:589	poly(ethylene glycol) diglycidyl ether	552:589	poly(ethylene glycol) diglycidyl ether (PEGDE)	552:597	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	3	71	theme	dimensional	708:718	arg1	scaffold					744:751	a three dimensional porous spongy composite scaffold	700:751	a three dimensional porous spongy composite scaffold	700:751	To the best of our knowledge, this is the first study in cartilage regeneration where a three dimensional porous spongy composite scaffold was obtained by the dispersion of wet-electrospun nanofibers within a polymer matrix.
32600090	4	72	theme	hydrogel	859:866	arg1	scaffolds					878:886	the produced hydrogel composite scaffolds	846:886	the produced hydrogel composite scaffolds	846:886	All of the produced hydrogel composite scaffolds had an interconnected microporous structure with well-integrated PHBV nanofibers on the pore walls.
32600090	2	73	theme	fibroin	462:468	arg1	scaffolds					505:513	carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds	434:513	carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced	434:611	In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl chitosan-silk fibroin (PNFs/CMCht-SF) hydrogel composite scaffolds that were chemically cross-linked by poly(ethylene glycol) diglycidyl ether (PEGDE) were produced.
32600090	1	74	theme	composite	270:278	arg1	structure					280:288	the hydrated composite structure	257:288	the hydrated composite structure of the cartilage extracellular matrix	257:326	The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix.
32600090	5	75	theme	compressive	1152:1162	arg1	values					1188:1193	compressive strength (457 ± 85 kPa) values	1152:1193	compressive strength (457 ± 85 kPa) values	1152:1193	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
32600090	3	76	theme	first	656:660	arg1	this					644:647	this	644:647	this	644:647	To the best of our knowledge, this is the first study in cartilage regeneration where a three dimensional porous spongy composite scaffold was obtained by the dispersion of wet-electrospun nanofibers within a polymer matrix.
32600090	3	76	theme	first	656:660	arg1	study					662:666	the first study	652:666	the first study in cartilage regeneration	652:692	To the best of our knowledge, this is the first study in cartilage regeneration where a three dimensional porous spongy composite scaffold was obtained by the dispersion of wet-electrospun nanofibers within a polymer matrix.
32600090	5	77	dep	δ	1130:1130	arg1	1 Hz					1142:1145	1 Hz	1142:1145	1 Hz	1142:1145	The scaffold comprising an equal amount of PEGDE and polymer (PNFs/CMCht-SF1:PEGDE1) demonstrated comparable water content (91.4 ± 0.7%), tan δ (0.183 at 1 Hz) and compressive strength (457 ± 85 kPa) values to that of articular cartilage.
34303154	4	0	theme	weight	787:792	arg1	heparin					794:800	a chemoenzymatically synthesized ultra-low molecular weight heparin	734:800	a chemoenzymatically synthesized ultra-low molecular weight heparin	734:800	Both recombinant thrombomodulin and a chemoenzymatically synthesized ultra-low molecular weight heparin were repeatedly and selectively immobilized or removed in a sequential, alternating, or simultaneous manner.
34303154	6	1	from	implantation	1270:1281	arg1	model					1292:1296	a rat model	1286:1296	a rat model	1286:1296	The fabrication of a rechargeable anti-thrombogenic surface was demonstrated on an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model.
34303154	2	2	theme	clinical	521:528	arg1	performance					530:540	its clinical performance	517:540	its clinical performance	517:540	As a consequence, the ability to restore the bioactivity of a surface coating after implantation of a blood-contacting device provides a potentially important strategy to enhance its clinical performance.
34303154	5	3	theme	activated	973:981	arg1	FXa					993:995	FXa	993:995	FXa	993:995	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	5	3	theme	activated	973:981	arg1	X					990:990	activated factor X	973:990	activated factor X (FXa)	973:996	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	4	4	theme	molecular	777:785	arg1	heparin					794:800	a chemoenzymatically synthesized ultra-low molecular weight heparin	734:800	a chemoenzymatically synthesized ultra-low molecular weight heparin	734:800	Both recombinant thrombomodulin and a chemoenzymatically synthesized ultra-low molecular weight heparin were repeatedly and selectively immobilized or removed in a sequential, alternating, or simultaneous manner.
34303154	1	5	theme	device	285:290	arg1	failure					292:298	device failure	285:298	device failure	285:298	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	6	6	with	graft	1193:1197	arg1	reconstitution					1204:1217	reconstitution	1204:1217	reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model	1204:1296	The fabrication of a rechargeable anti-thrombogenic surface was demonstrated on an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model.
34303154	5	7	theme	molecular	1022:1030	arg1	composition					1032:1042	the molecular composition	1018:1042	the molecular composition of the surface	1018:1057	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	6	8	theme	surface	1226:1232	arg1	reconstitution					1204:1217	reconstitution	1204:1217	reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model	1204:1296	The fabrication of a rechargeable anti-thrombogenic surface was demonstrated on an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model.
34303154	6	9	theme	in	1262:1263	arg1	implantation					1270:1281	in vivo implantation	1262:1281	in vivo implantation in a rat model	1262:1296	The fabrication of a rechargeable anti-thrombogenic surface was demonstrated on an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model.
34303154	3	10	theme	multicomponent	581:594	arg1	coating					614:620	a multicomponent anti-thrombogenic coating	579:620	a multicomponent anti-thrombogenic coating	579:620	Here, we report the regeneration of a multicomponent anti-thrombogenic coating through use of an evolved sortase A to mediate reversible transpeptidation.
34303154	5	11	theme	X	990:990	arg1	aPC					950:952	aPC	950:952	aPC	950:952	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	5	11	theme	X	990:990	arg1	inhibition					959:968	inhibition	959:968	inhibition of activated factor X (FXa)	959:996	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	5	11	theme	X	990:990	arg1	C					947:947	activated protein C	929:947	activated protein C (aPC)	929:953	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	5	12	theme	activated	929:937	arg1	aPC					950:952	aPC	950:952	aPC	950:952	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	5	12	theme	activated	929:937	arg1	C					947:947	activated protein C	929:947	activated protein C (aPC)	929:953	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	6	13	theme	expanded	1143:1150	arg1	graft					1193:1197	an expanded polytetrafluoroethylene (ePTFE) vascular graft	1140:1197	an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model	1140:1296	The fabrication of a rechargeable anti-thrombogenic surface was demonstrated on an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model.
34303154	1	14	theme	blood-contacting	184:199	arg1	devices					201:207	blood-contacting devices	184:207	blood-contacting devices	184:207	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	5	15	theme	factor	983:988	arg1	FXa					993:995	FXa	993:995	FXa	993:995	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	5	15	theme	factor	983:988	arg1	X					990:990	activated factor X	973:990	activated factor X (FXa)	973:996	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	4	16	theme	simultaneous	890:901	arg1	manner					903:908	a sequential, alternating, or simultaneous manner	860:908	a sequential, alternating, or simultaneous manner	860:908	Both recombinant thrombomodulin and a chemoenzymatically synthesized ultra-low molecular weight heparin were repeatedly and selectively immobilized or removed in a sequential, alternating, or simultaneous manner.
34303154	4	17	theme	sequential	862:871	arg1	manner					903:908	a sequential, alternating, or simultaneous manner	860:908	a sequential, alternating, or simultaneous manner	860:908	Both recombinant thrombomodulin and a chemoenzymatically synthesized ultra-low molecular weight heparin were repeatedly and selectively immobilized or removed in a sequential, alternating, or simultaneous manner.
34303154	6	18	theme	ePTFE	1177:1181	arg1	graft					1193:1197	an expanded polytetrafluoroethylene (ePTFE) vascular graft	1140:1197	an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model	1140:1296	The fabrication of a rechargeable anti-thrombogenic surface was demonstrated on an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model.
34303154	1	19	theme	devices	201:207	arg1	performance					169:179	the performance	165:179	the performance of blood-contacting devices	165:207	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	2	20	theme	important	487:495	arg1	consequence					343:353	a consequence	341:353	a consequence	341:353	As a consequence, the ability to restore the bioactivity of a surface coating after implantation of a blood-contacting device provides a potentially important strategy to enhance its clinical performance.
34303154	2	20	theme	important	487:495	arg1	strategy					497:504	a potentially important strategy	473:504	a potentially important strategy to enhance its clinical performance	473:540	As a consequence, the ability to restore the bioactivity of a surface coating after implantation of a blood-contacting device provides a potentially important strategy to enhance its clinical performance.
34303154	1	21	theme	anti-thrombogenic	94:110	arg1	coatings					112:119	anti-thrombogenic coatings	94:119	anti-thrombogenic coatings	94:119	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	1	21	theme	anti-thrombogenic	94:110	arg1	surfaces					144:151	heparinized surfaces	132:151	heparinized surfaces	132:151	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	2	22	theme	coating	408:414	arg1	bioactivity					383:393	the bioactivity	379:393	the bioactivity of a surface coating	379:414	As a consequence, the ability to restore the bioactivity of a surface coating after implantation of a blood-contacting device provides a potentially important strategy to enhance its clinical performance.
34303154	1	23	theme	related	304:310	arg1	complications					323:335	related thrombotic complications	304:335	related thrombotic complications	304:335	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	1	24	theme	coatings	112:119	arg1	potential					81:89	the potential	77:89	the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices	77:207	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	2	25	theme	surface	400:406	arg1	coating					408:414	a surface coating	398:414	a surface coating	398:414	As a consequence, the ability to restore the bioactivity of a surface coating after implantation of a blood-contacting device provides a potentially important strategy to enhance its clinical performance.
34303154	1	26	theme	thrombotic	312:321	arg1	complications					323:335	related thrombotic complications	304:335	related thrombotic complications	304:335	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	6	27	dep	in	1262:1263	arg1	vivo					1265:1268	vivo	1265:1268	vivo	1265:1268	The fabrication of a rechargeable anti-thrombogenic surface was demonstrated on an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model.
34303154	3	28	theme	anti-thrombogenic	596:612	arg1	coating					614:620	a multicomponent anti-thrombogenic coating	579:620	a multicomponent anti-thrombogenic coating	579:620	Here, we report the regeneration of a multicomponent anti-thrombogenic coating through use of an evolved sortase A to mediate reversible transpeptidation.
34303154	2	29	theme	device	457:462	arg1	implantation					422:433	implantation	422:433	implantation of a blood-contacting device	422:462	As a consequence, the ability to restore the bioactivity of a surface coating after implantation of a blood-contacting device provides a potentially important strategy to enhance its clinical performance.
34303154	0	30	theme	anti-thrombotic	15:29	arg1	coating					31:37	A rechargeable anti-thrombotic coating	0:37	A rechargeable anti-thrombotic coating for blood-contacting devices	0:66	A rechargeable anti-thrombotic coating for blood-contacting devices.
34303154	3	31	theme	coating	614:620	arg1	regeneration					563:574	the regeneration	559:574	the regeneration of a multicomponent anti-thrombogenic coating through use of an evolved sortase A	559:656	Here, we report the regeneration of a multicomponent anti-thrombogenic coating through use of an evolved sortase A to mediate reversible transpeptidation.
34303154	2	32	theme	blood-contacting	440:455	arg1	device					457:462	a blood-contacting device	438:462	a blood-contacting device	438:462	As a consequence, the ability to restore the bioactivity of a surface coating after implantation of a blood-contacting device provides a potentially important strategy to enhance its clinical performance.
34303154	0	33	theme	blood-contacting	43:58	arg1	devices					60:66	blood-contacting devices	43:66	blood-contacting devices	43:66	A rechargeable anti-thrombotic coating for blood-contacting devices.
34303154	5	34	theme	protein	939:945	arg1	aPC					950:952	aPC	950:952	aPC	950:952	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	5	34	theme	protein	939:945	arg1	C					947:947	activated protein C	929:947	activated protein C (aPC)	929:953	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	3	35	theme	evolved	640:646	arg1	A					656:656	an evolved sortase A	637:656	an evolved sortase A	637:656	Here, we report the regeneration of a multicomponent anti-thrombogenic coating through use of an evolved sortase A to mediate reversible transpeptidation.
34303154	4	36	theme	recombinant	703:713	arg1	thrombomodulin					715:728	recombinant thrombomodulin	703:728	recombinant thrombomodulin	703:728	Both recombinant thrombomodulin and a chemoenzymatically synthesized ultra-low molecular weight heparin were repeatedly and selectively immobilized or removed in a sequential, alternating, or simultaneous manner.
34303154	3	37	theme	sortase	648:654	arg1	A					656:656	an evolved sortase A	637:656	an evolved sortase A	637:656	Here, we report the regeneration of a multicomponent anti-thrombogenic coating through use of an evolved sortase A to mediate reversible transpeptidation.
34303154	1	38	theme	bioactivity	242:252	arg1	deterioration					225:237	the inevitable deterioration	210:237	the inevitable deterioration of bioactivity	210:252	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	5	39	theme	inhibition	959:968	arg1	consistent					1002:1011	consistent	1002:1011	consistent	1002:1011	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	5	39	theme	inhibition	959:968	arg1	generation					915:924	The generation	911:924	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa)	911:996	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	6	40	theme	surface	1112:1118	arg1	fabrication					1064:1074	The fabrication	1060:1074	The fabrication of a rechargeable anti-thrombogenic surface	1060:1118	The fabrication of a rechargeable anti-thrombogenic surface was demonstrated on an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model.
34303154	6	41	theme	vascular	1184:1191	arg1	graft					1193:1197	an expanded polytetrafluoroethylene (ePTFE) vascular graft	1140:1197	an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model	1140:1296	The fabrication of a rechargeable anti-thrombogenic surface was demonstrated on an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model.
34303154	1	42	theme	heparinized	132:142	arg1	surfaces					144:151	heparinized surfaces	132:151	heparinized surfaces	132:151	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	1	43	from	factor	275:280	arg1	complications					323:335	related thrombotic complications	304:335	related thrombotic complications	304:335	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	1	43	from	factor	275:280	arg1	failure					292:298	device failure	285:298	device failure	285:298	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	6	44	theme	rat	1288:1290	arg1	model					1292:1296	a rat model	1286:1296	a rat model	1286:1296	The fabrication of a rechargeable anti-thrombogenic surface was demonstrated on an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model.
34303154	5	45	theme	surface	1051:1057	arg1	composition					1032:1042	the molecular composition	1018:1042	the molecular composition of the surface	1018:1057	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	6	46	theme	anti-thrombogenic	1094:1110	arg1	surface					1112:1118	a rechargeable anti-thrombogenic surface	1079:1118	a rechargeable anti-thrombogenic surface	1079:1118	The fabrication of a rechargeable anti-thrombogenic surface was demonstrated on an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model.
34303154	4	47	theme	alternating	874:884	arg1	manner					903:908	a sequential, alternating, or simultaneous manner	860:908	a sequential, alternating, or simultaneous manner	860:908	Both recombinant thrombomodulin and a chemoenzymatically synthesized ultra-low molecular weight heparin were repeatedly and selectively immobilized or removed in a sequential, alternating, or simultaneous manner.
34303154	4	48	theme	synthesized	755:765	arg1	heparin					794:800	a chemoenzymatically synthesized ultra-low molecular weight heparin	734:800	a chemoenzymatically synthesized ultra-low molecular weight heparin	734:800	Both recombinant thrombomodulin and a chemoenzymatically synthesized ultra-low molecular weight heparin were repeatedly and selectively immobilized or removed in a sequential, alternating, or simultaneous manner.
34303154	6	49	theme	rechargeable	1081:1092	arg1	surface					1112:1118	a rechargeable anti-thrombogenic surface	1079:1118	a rechargeable anti-thrombogenic surface	1079:1118	The fabrication of a rechargeable anti-thrombogenic surface was demonstrated on an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model.
34303154	5	50	theme	C	947:947	arg1	consistent					1002:1011	consistent	1002:1011	consistent	1002:1011	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	5	50	theme	C	947:947	arg1	generation					915:924	The generation	911:924	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa)	911:996	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	3	51	theme	A	656:656	arg1	use					630:632	use	630:632	use of an evolved sortase A	630:656	Here, we report the regeneration of a multicomponent anti-thrombogenic coating through use of an evolved sortase A to mediate reversible transpeptidation.
34303154	1	52	theme	inevitable	214:223	arg1	deterioration					225:237	the inevitable deterioration	210:237	the inevitable deterioration of bioactivity	210:252	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	4	53	theme	ultra-low	767:775	arg1	heparin					794:800	a chemoenzymatically synthesized ultra-low molecular weight heparin	734:800	a chemoenzymatically synthesized ultra-low molecular weight heparin	734:800	Both recombinant thrombomodulin and a chemoenzymatically synthesized ultra-low molecular weight heparin were repeatedly and selectively immobilized or removed in a sequential, alternating, or simultaneous manner.
34303154	6	54	theme	polytetrafluoroethylene	1152:1174	arg1	graft					1193:1197	an expanded polytetrafluoroethylene (ePTFE) vascular graft	1140:1197	an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model	1140:1296	The fabrication of a rechargeable anti-thrombogenic surface was demonstrated on an expanded polytetrafluoroethylene (ePTFE) vascular graft with reconstitution of the surface bound coating 4 weeks after in vivo implantation in a rat model.
34303154	1	55	theme	important	265:273	arg1	factor					275:280	an important factor	262:280	an important factor in device failure and related thrombotic complications	262:335	Despite the potential of anti-thrombogenic coatings, including heparinized surfaces, to improve the performance of blood-contacting devices, the inevitable deterioration of bioactivity remains an important factor in device failure and related thrombotic complications.
34303154	5	56	with	consistent	1002:1011	arg1	composition					1032:1042	the molecular composition	1018:1042	the molecular composition of the surface	1018:1057	The generation of activated protein C (aPC) and inhibition of activated factor X (FXa) was consistent with the molecular composition of the surface.
34303154	0	57	theme	rechargeable	2:13	arg1	coating					31:37	A rechargeable anti-thrombotic coating	0:37	A rechargeable anti-thrombotic coating for blood-contacting devices	0:66	A rechargeable anti-thrombotic coating for blood-contacting devices.
32910260	12	0	theme	functional	1759:1768	arg1	genes					1770:1774	the functional genes	1755:1774	the functional genes of gut microbiota involved in valine, leucine, and isoleucine biosynthesis	1755:1849	In PICRUSt2, chitosan upregulated the functional genes of gut microbiota involved in valine, leucine, and isoleucine biosynthesis, whereas the OVX-Control exhibited significantly upregulated lipopolysaccharide biosynthesis.
32910260	6	1	theme	fecal	1006:1010	arg1	samples					1012:1018	the fecal samples	1002:1018	the fecal samples	1002:1018	Gut microbiota in the fecal samples was measured by NGS and analyzed with PICRUSt2.
32910260	13	2	theme	increased	1966:1974	arg1	α-diversity					1976:1986	increased α-diversity	1966:1986	increased α-diversity in the fecal bacteria	1966:2008	OVX-Pectin exhibited increased α-diversity in the fecal bacteria.
32910260	15	3	dep	diversity	2316:2324	arg1	the					2312:2314	the	2312:2314	the	2312:2314	CONCLUSION Chitosan and citrus pectin consumptions improved menopausal symptoms by improving the diversity and composition of the gut microbiota, and serum metabolites and SCFA originating from fecal bacteria.
32910260	4	4	theme	same	805:808	arg1	diet					810:813	the same diet	801:813	the same diet	801:813	Sham-operated rats had the same diet as OVX-Control (Normal-Control).
32910260	1	5	theme	menopausal	275:284	arg1	disorders					296:304	menopausal metabolic disorders	275:304	menopausal metabolic disorders	275:304	PURPOSE Menopause disturbs energy, glucose, and lipid metabolisms and changes the composition of the gut microbiota, but dietary fibers without phytoestrogens may ameliorate menopausal metabolic disorders.
32910260	4	6	theme	Sham-operated	778:790	arg1	rats					792:795	Sham-operated rats	778:795	Sham-operated rats	778:795	Sham-operated rats had the same diet as OVX-Control (Normal-Control).
32910260	3	7	theme	fat	693:695	arg1	diet					697:700	a 43% fat diet	687:700	a 43% fat diet	687:700	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	3	8	theme	43	689:690	arg1	%					691:691	%	691:691	%	691:691	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	15	9	theme	fecal	2413:2417	arg1	bacteria					2419:2426	fecal bacteria	2413:2426	fecal bacteria	2413:2426	CONCLUSION Chitosan and citrus pectin consumptions improved menopausal symptoms by improving the diversity and composition of the gut microbiota, and serum metabolites and SCFA originating from fecal bacteria.
32910260	14	10	dep	higher	2041:2046	arg1	concentrations					2060:2073	serum urate concentrations	2048:2073	serum urate concentrations	2048:2073	Metabolomic analysis revealed higher serum urate concentrations in the OVX-Control group than the other groups, and serum arginine and leucine concentrations were higher in the OVX-Chitosan group (P < 0.05).
32910260	9	11	theme	fat	1391:1393	arg1	content					1395:1401	visceral fat content	1382:1401	visceral fat content	1382:1401	OVX-Chitosan reduced the weight, visceral fat content, and tail skin temperature, and OVX-Chitosan and OVX-Pectin improved glucose tolerance, compared to the OVX-Control.
32910260	15	12	theme	pectin	2250:2255	arg1	consumptions					2257:2268	citrus pectin consumptions	2243:2268	citrus pectin consumptions	2243:2268	CONCLUSION Chitosan and citrus pectin consumptions improved menopausal symptoms by improving the diversity and composition of the gut microbiota, and serum metabolites and SCFA originating from fecal bacteria.
32910260	3	13	theme	sham	710:713	arg1	OVX-Control					752:762	the OVX-Control	748:762	the OVX-Control for 12 weeks	748:775	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	3	13	theme	sham	710:713	arg1	diet					740:743	the same diet	731:743	the same diet	731:743	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	3	13	theme	sham	710:713	arg1	rats					715:718	the sham rats	706:718	the sham rats	706:718	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	0	14	from	microbiota	62:71	arg1	rats					95:98	estrogen-deficient rats	76:98	estrogen-deficient rats	76:98	Chitosan alleviated menopausal symptoms and modulated the gut microbiota in estrogen-deficient rats.
32910260	8	15	theme	citrus	1209:1214	arg1	pectin					1216:1221	citrus pectin	1209:1221	citrus pectin	1209:1221	RESULTS Chitosan and citrus pectin were selected because the incubation of rat feces with these two prebiotics in vitro had shown increased butyrate production.
32910260	8	15	theme	citrus	1209:1214	arg1	RESULTS					1188:1194	RESULTS	1188:1194	RESULTS Chitosan and citrus pectin	1188:1221	RESULTS Chitosan and citrus pectin were selected because the incubation of rat feces with these two prebiotics in vitro had shown increased butyrate production.
32910260	16	16	theme	citrus	2496:2501	arg1	pectin					2503:2508	citrus pectin	2496:2508	citrus pectin	2496:2508	Chitosan was more effective for improving menopausal symptoms than citrus pectin.
32910260	5	17	theme	insulin	949:955	arg1	tolerance					957:965	insulin tolerance	949:965	insulin tolerance	949:965	Body-weight, visceral fat mass, tail skin temperature, serum 17β-estradiol, glucose intolerance, and insulin tolerance were determined.
32910260	9	18	theme	tail	1408:1411	arg1	temperature					1418:1428	tail skin temperature	1408:1428	tail skin temperature	1408:1428	OVX-Chitosan reduced the weight, visceral fat content, and tail skin temperature, and OVX-Chitosan and OVX-Pectin improved glucose tolerance, compared to the OVX-Control.
32910260	15	19	theme	serum	2369:2373	arg1	metabolites					2375:2385	serum metabolites	2369:2385	serum metabolites	2369:2385	CONCLUSION Chitosan and citrus pectin consumptions improved menopausal symptoms by improving the diversity and composition of the gut microbiota, and serum metabolites and SCFA originating from fecal bacteria.
32910260	5	20	theme	Body-weight	848:858	arg1	mass					874:877	Body-weight, visceral fat mass	848:877	Body-weight, visceral fat mass	848:877	Body-weight, visceral fat mass, tail skin temperature, serum 17β-estradiol, glucose intolerance, and insulin tolerance were determined.
32910260	11	21	theme	serum	1691:1695	arg1	concentrations					1705:1718	OVX-Chitosan lowered serum acetate concentrations	1670:1718	serum propionate and butyrate concentrations but only OVX-Chitosan lowered serum acetate concentrations	1616:1718	OVX-Chitosan and OVX-Pectin elevated serum propionate and butyrate concentrations but only OVX-Chitosan lowered serum acetate concentrations.
32910260	0	22	theme	menopausal	20:29	arg1	symptoms					31:38	menopausal symptoms	20:38	menopausal symptoms	20:38	Chitosan alleviated menopausal symptoms and modulated the gut microbiota in estrogen-deficient rats.
32910260	1	23	theme	lipid	149:153	arg1	metabolisms					155:165	lipid metabolisms	149:165	lipid metabolisms	149:165	PURPOSE Menopause disturbs energy, glucose, and lipid metabolisms and changes the composition of the gut microbiota, but dietary fibers without phytoestrogens may ameliorate menopausal metabolic disorders.
32910260	14	24	theme	leucine	2146:2152	arg1	concentrations					2154:2167	serum arginine and leucine concentrations	2127:2167	concentrations	2154:2167	Metabolomic analysis revealed higher serum urate concentrations in the OVX-Control group than the other groups, and serum arginine and leucine concentrations were higher in the OVX-Chitosan group (P < 0.05).
32910260	0	25	theme	estrogen-deficient	76:93	arg1	rats					95:98	estrogen-deficient rats	76:98	estrogen-deficient rats	76:98	Chitosan alleviated menopausal symptoms and modulated the gut microbiota in estrogen-deficient rats.
32910260	13	26	from	α-diversity	1976:1986	arg1	bacteria					2001:2008	the fecal bacteria	1991:2008	the fecal bacteria	1991:2008	OVX-Pectin exhibited increased α-diversity in the fecal bacteria.
32910260	8	27	theme	rat	1263:1265	arg1	feces					1267:1271	rat feces	1263:1271	rat feces	1263:1271	RESULTS Chitosan and citrus pectin were selected because the incubation of rat feces with these two prebiotics in vitro had shown increased butyrate production.
32910260	7	28	theme	metabolomic	1103:1113	arg1	characteristics					1115:1129	metabolomic characteristics	1103:1129	metabolomic characteristics of serum	1103:1138	Short-chain fatty acids (SCFA) and metabolomic characteristics of serum were also measured with UPLC-mass spectrometry.
32910260	12	29	theme	upregulated	1900:1910	arg1	biosynthesis					1931:1942	significantly upregulated lipopolysaccharide biosynthesis	1886:1942	significantly upregulated lipopolysaccharide biosynthesis	1886:1942	In PICRUSt2, chitosan upregulated the functional genes of gut microbiota involved in valine, leucine, and isoleucine biosynthesis, whereas the OVX-Control exhibited significantly upregulated lipopolysaccharide biosynthesis.
32910260	8	30	dep	RESULTS	1188:1194	arg1	pectin					1216:1221	citrus pectin	1209:1221	citrus pectin	1209:1221	RESULTS Chitosan and citrus pectin were selected because the incubation of rat feces with these two prebiotics in vitro had shown increased butyrate production.
32910260	8	30	dep	RESULTS	1188:1194	arg1	RESULTS					1188:1194	RESULTS	1188:1194	RESULTS Chitosan and citrus pectin	1188:1221	RESULTS Chitosan and citrus pectin were selected because the incubation of rat feces with these two prebiotics in vitro had shown increased butyrate production.
32910260	8	30	dep	RESULTS	1188:1194	arg1	Chitosan					1196:1203	Chitosan	1196:1203	Chitosan	1196:1203	RESULTS Chitosan and citrus pectin were selected because the incubation of rat feces with these two prebiotics in vitro had shown increased butyrate production.
32910260	2	31	from	microbiota	484:493	arg1	rats					519:522	ovariectomized (OVX) rats	498:522	ovariectomized (OVX) rats	498:522	The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can improve postmenopausal symptoms, possibly by modulating the gut microbiota in ovariectomized (OVX) rats, and the mechanism of action was examined.
32910260	1	32	theme	metabolic	286:294	arg1	disorders					296:304	menopausal metabolic disorders	275:304	menopausal metabolic disorders	275:304	PURPOSE Menopause disturbs energy, glucose, and lipid metabolisms and changes the composition of the gut microbiota, but dietary fibers without phytoestrogens may ameliorate menopausal metabolic disorders.
32910260	1	33	theme	PURPOSE	101:107	arg1	Menopause					109:117	PURPOSE Menopause	101:117	PURPOSE Menopause	101:117	PURPOSE Menopause disturbs energy, glucose, and lipid metabolisms and changes the composition of the gut microbiota, but dietary fibers without phytoestrogens may ameliorate menopausal metabolic disorders.
32910260	7	34	theme	fatty	1080:1084	arg1	SCFA					1093:1096	SCFA	1093:1096	SCFA	1093:1096	Short-chain fatty acids (SCFA) and metabolomic characteristics of serum were also measured with UPLC-mass spectrometry.
32910260	7	34	theme	fatty	1080:1084	arg1	acids					1086:1090	Short-chain fatty acids	1068:1090	Short-chain fatty acids (SCFA)	1068:1097	Short-chain fatty acids (SCFA) and metabolomic characteristics of serum were also measured with UPLC-mass spectrometry.
32910260	15	35	theme	menopausal	2279:2288	arg1	symptoms					2290:2297	menopausal symptoms	2279:2297	menopausal symptoms	2279:2297	CONCLUSION Chitosan and citrus pectin consumptions improved menopausal symptoms by improving the diversity and composition of the gut microbiota, and serum metabolites and SCFA originating from fecal bacteria.
32910260	12	36	theme	isoleucine	1827:1836	arg1	biosynthesis					1838:1849	isoleucine biosynthesis	1827:1849	isoleucine biosynthesis	1827:1849	In PICRUSt2, chitosan upregulated the functional genes of gut microbiota involved in valine, leucine, and isoleucine biosynthesis, whereas the OVX-Control exhibited significantly upregulated lipopolysaccharide biosynthesis.
32910260	12	37	theme	gut	1779:1781	arg1	microbiota					1783:1792	gut microbiota	1779:1792	gut microbiota	1779:1792	In PICRUSt2, chitosan upregulated the functional genes of gut microbiota involved in valine, leucine, and isoleucine biosynthesis, whereas the OVX-Control exhibited significantly upregulated lipopolysaccharide biosynthesis.
32910260	2	38	theme	gut	480:482	arg1	microbiota					484:493	the gut microbiota	476:493	the gut microbiota in ovariectomized (OVX) rats	476:522	The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can improve postmenopausal symptoms, possibly by modulating the gut microbiota in ovariectomized (OVX) rats, and the mechanism of action was examined.
32910260	8	39	theme	increased	1318:1326	arg1	production					1337:1346	increased butyrate production	1318:1346	increased butyrate production	1318:1346	RESULTS Chitosan and citrus pectin were selected because the incubation of rat feces with these two prebiotics in vitro had shown increased butyrate production.
32910260	2	40	dep	ovariectomized	498:511	arg1	OVX					514:516	OVX	514:516	OVX	514:516	The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can improve postmenopausal symptoms, possibly by modulating the gut microbiota in ovariectomized (OVX) rats, and the mechanism of action was examined.
32910260	3	41	theme	%	602:602	arg1	OVX-Control					615:625	OVX-Control	615:625	OVX-Control	615:625	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	3	41	theme	%	602:602	arg1	cellulose					604:612	4.5% cellulose	599:612	4.5% cellulose (OVX-Control)	599:626	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	11	42	theme	lowered	1683:1689	arg1	concentrations					1705:1718	OVX-Chitosan lowered serum acetate concentrations	1670:1718	serum propionate and butyrate concentrations but only OVX-Chitosan lowered serum acetate concentrations	1616:1718	OVX-Chitosan and OVX-Pectin elevated serum propionate and butyrate concentrations but only OVX-Chitosan lowered serum acetate concentrations.
32910260	5	43	theme	serum	903:907	arg1	17β-estradiol					909:921	serum 17β-estradiol	903:921	serum 17β-estradiol	903:921	Body-weight, visceral fat mass, tail skin temperature, serum 17β-estradiol, glucose intolerance, and insulin tolerance were determined.
32910260	2	44	theme	prebiotics	378:387	arg1	chitosan					389:396	prebiotics chitosan	378:396	prebiotics chitosan	378:396	The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can improve postmenopausal symptoms, possibly by modulating the gut microbiota in ovariectomized (OVX) rats, and the mechanism of action was examined.
32910260	15	45	theme	gut	2349:2351	arg1	microbiota					2353:2362	the gut microbiota	2345:2362	the gut microbiota	2345:2362	CONCLUSION Chitosan and citrus pectin consumptions improved menopausal symptoms by improving the diversity and composition of the gut microbiota, and serum metabolites and SCFA originating from fecal bacteria.
32910260	7	46	theme	UPLC-mass	1164:1172	arg1	spectrometry					1174:1185	UPLC-mass spectrometry	1164:1185	UPLC-mass spectrometry	1164:1185	Short-chain fatty acids (SCFA) and metabolomic characteristics of serum were also measured with UPLC-mass spectrometry.
32910260	2	47	theme	consuming	364:372	arg1	chitosan					389:396	prebiotics chitosan	378:396	prebiotics chitosan	378:396	The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can improve postmenopausal symptoms, possibly by modulating the gut microbiota in ovariectomized (OVX) rats, and the mechanism of action was examined.
32910260	3	48	theme	citrus	657:662	arg1	pectin					664:669	citrus pectin	657:669	citrus pectin (OVX-Pectin)	657:682	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	3	48	theme	citrus	657:662	arg1	OVX-Pectin					672:681	OVX-Pectin	672:681	OVX-Pectin	672:681	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	11	49	theme	serum	1616:1620	arg1	propionate					1622:1631	serum propionate and butyrate concentrations	1616:1659	propionate	1622:1631	OVX-Chitosan and OVX-Pectin elevated serum propionate and butyrate concentrations but only OVX-Chitosan lowered serum acetate concentrations.
32910260	6	50	from	microbiota	988:997	arg1	samples					1012:1018	the fecal samples	1002:1018	the fecal samples	1002:1018	Gut microbiota in the fecal samples was measured by NGS and analyzed with PICRUSt2.
32910260	2	51	theme	present	328:334	arg1	study					336:340	the present study	324:340	the present study	324:340	The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can improve postmenopausal symptoms, possibly by modulating the gut microbiota in ovariectomized (OVX) rats, and the mechanism of action was examined.
32910260	8	52	with	incubation	1249:1258	arg1	prebiotics					1288:1297	these two prebiotics	1278:1297	these two prebiotics	1278:1297	RESULTS Chitosan and citrus pectin were selected because the incubation of rat feces with these two prebiotics in vitro had shown increased butyrate production.
32910260	14	53	theme	OVX-Chitosan	2188:2199	arg1	P < 0.05					2208:2215	P < 0.05	2208:2215	P < 0.05	2208:2215	Metabolomic analysis revealed higher serum urate concentrations in the OVX-Control group than the other groups, and serum arginine and leucine concentrations were higher in the OVX-Chitosan group (P < 0.05).
32910260	14	53	theme	OVX-Chitosan	2188:2199	arg1	group					2201:2205	the OVX-Chitosan group	2184:2205	the OVX-Chitosan group (P < 0.05)	2184:2216	Metabolomic analysis revealed higher serum urate concentrations in the OVX-Control group than the other groups, and serum arginine and leucine concentrations were higher in the OVX-Chitosan group (P < 0.05).
32910260	9	54	theme	visceral	1382:1389	arg1	fat					1391:1393	visceral fat	1382:1393	visceral fat content	1382:1401	OVX-Chitosan reduced the weight, visceral fat content, and tail skin temperature, and OVX-Chitosan and OVX-Pectin improved glucose tolerance, compared to the OVX-Control.
32910260	2	55	theme	action	546:551	arg1	mechanism					533:541	the mechanism	529:541	the mechanism of action	529:551	The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can improve postmenopausal symptoms, possibly by modulating the gut microbiota in ovariectomized (OVX) rats, and the mechanism of action was examined.
32910260	15	56	dep	CONCLUSION	2219:2228	arg1	Chitosan					2230:2237	Chitosan	2230:2237	Chitosan	2230:2237	CONCLUSION Chitosan and citrus pectin consumptions improved menopausal symptoms by improving the diversity and composition of the gut microbiota, and serum metabolites and SCFA originating from fecal bacteria.
32910260	3	57	theme	%	691:691	arg1	diet					697:700	a 43% fat diet	687:700	a 43% fat diet	687:700	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	1	58	theme	microbiota	206:215	arg1	composition					183:193	the composition	179:193	the composition of the gut microbiota	179:215	PURPOSE Menopause disturbs energy, glucose, and lipid metabolisms and changes the composition of the gut microbiota, but dietary fibers without phytoestrogens may ameliorate menopausal metabolic disorders.
32910260	3	59	theme	OVX	579:581	arg1	rats					583:586	The OVX rats	575:586	The OVX rats	575:586	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	15	60	theme	citrus	2243:2248	arg1	consumptions					2257:2268	citrus pectin consumptions	2243:2268	citrus pectin consumptions	2243:2268	CONCLUSION Chitosan and citrus pectin consumptions improved menopausal symptoms by improving the diversity and composition of the gut microbiota, and serum metabolites and SCFA originating from fecal bacteria.
32910260	9	61	theme	skin	1413:1416	arg1	temperature					1418:1428	tail skin temperature	1408:1428	tail skin temperature	1408:1428	OVX-Chitosan reduced the weight, visceral fat content, and tail skin temperature, and OVX-Chitosan and OVX-Pectin improved glucose tolerance, compared to the OVX-Control.
32910260	3	62	theme	same	735:738	arg1	rats					715:718	the sham rats	706:718	the sham rats	706:718	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	3	62	theme	same	735:738	arg1	diet					740:743	the same diet	731:743	the same diet	731:743	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	3	62	theme	same	735:738	arg1	OVX-Control					752:762	the OVX-Control	748:762	the OVX-Control for 12 weeks	748:775	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	7	63	theme	serum	1134:1138	arg1	SCFA					1093:1096	SCFA	1093:1096	SCFA	1093:1096	Short-chain fatty acids (SCFA) and metabolomic characteristics of serum were also measured with UPLC-mass spectrometry.
32910260	7	63	theme	serum	1134:1138	arg1	acids					1086:1090	Short-chain fatty acids	1068:1090	Short-chain fatty acids (SCFA)	1068:1097	Short-chain fatty acids (SCFA) and metabolomic characteristics of serum were also measured with UPLC-mass spectrometry.
32910260	7	63	theme	serum	1134:1138	arg1	characteristics					1115:1129	metabolomic characteristics	1103:1129	metabolomic characteristics of serum	1103:1138	Short-chain fatty acids (SCFA) and metabolomic characteristics of serum were also measured with UPLC-mass spectrometry.
32910260	3	64	theme	4.5	599:601	arg1	%					602:602	%	602:602	%	602:602	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	11	65	theme	acetate	1697:1703	arg1	concentrations					1705:1718	OVX-Chitosan lowered serum acetate concentrations	1670:1718	serum propionate and butyrate concentrations but only OVX-Chitosan lowered serum acetate concentrations	1616:1718	OVX-Chitosan and OVX-Pectin elevated serum propionate and butyrate concentrations but only OVX-Chitosan lowered serum acetate concentrations.
32910260	3	66	dep	METHODS	567:573	arg1	given					593:597	given	593:597	were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet	588:700	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	3	66	dep	METHODS	567:573	arg1	given					725:729	given	725:729	were given the same diet as the OVX-Control for 12 weeks	720:775	METHODS The OVX rats were given 4.5% cellulose (OVX-Control), chitosan (OVX-Chitosan), or citrus pectin (OVX-Pectin) in a 43% fat diet and the sham rats were given the same diet as the OVX-Control for 12 weeks.
32910260	2	67	theme	ovariectomized	498:511	arg1	rats					519:522	ovariectomized (OVX) rats	498:522	ovariectomized (OVX) rats	498:522	The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can improve postmenopausal symptoms, possibly by modulating the gut microbiota in ovariectomized (OVX) rats, and the mechanism of action was examined.
32910260	14	68	theme	serum	2127:2131	arg1	arginine					2133:2140	serum arginine and leucine concentrations	2127:2167	arginine	2133:2140	Metabolomic analysis revealed higher serum urate concentrations in the OVX-Control group than the other groups, and serum arginine and leucine concentrations were higher in the OVX-Chitosan group (P < 0.05).
32910260	2	69	dep	chitosan	389:396	arg1	the					374:376	the	374:376	the	374:376	The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can improve postmenopausal symptoms, possibly by modulating the gut microbiota in ovariectomized (OVX) rats, and the mechanism of action was examined.
32910260	12	70	theme	lipopolysaccharide	1912:1929	arg1	biosynthesis					1931:1942	significantly upregulated lipopolysaccharide biosynthesis	1886:1942	significantly upregulated lipopolysaccharide biosynthesis	1886:1942	In PICRUSt2, chitosan upregulated the functional genes of gut microbiota involved in valine, leucine, and isoleucine biosynthesis, whereas the OVX-Control exhibited significantly upregulated lipopolysaccharide biosynthesis.
32910260	14	71	theme	serum	2048:2052	arg1	concentrations					2060:2073	serum urate concentrations	2048:2073	serum urate concentrations	2048:2073	Metabolomic analysis revealed higher serum urate concentrations in the OVX-Control group than the other groups, and serum arginine and leucine concentrations were higher in the OVX-Chitosan group (P < 0.05).
32910260	4	72	contain	had	797:799	arg2	diet					810:813	the same diet	801:813	the same diet	801:813	Sham-operated rats had the same diet as OVX-Control (Normal-Control).
32910260	4	72	contain	had	797:799	arg1	rats					792:795	Sham-operated rats	778:795	Sham-operated rats	778:795	Sham-operated rats had the same diet as OVX-Control (Normal-Control).
32910260	5	73	theme	tail	880:883	arg1	temperature					890:900	tail skin temperature	880:900	tail skin temperature	880:900	Body-weight, visceral fat mass, tail skin temperature, serum 17β-estradiol, glucose intolerance, and insulin tolerance were determined.
32910260	5	74	dep	Body-weight	848:858	arg1	visceral					861:868	visceral	861:868	visceral	861:868	Body-weight, visceral fat mass, tail skin temperature, serum 17β-estradiol, glucose intolerance, and insulin tolerance were determined.
32910260	1	75	theme	gut	202:204	arg1	microbiota					206:215	the gut microbiota	198:215	the gut microbiota	198:215	PURPOSE Menopause disturbs energy, glucose, and lipid metabolisms and changes the composition of the gut microbiota, but dietary fibers without phytoestrogens may ameliorate menopausal metabolic disorders.
32910260	5	76	theme	skin	885:888	arg1	temperature					890:900	tail skin temperature	880:900	tail skin temperature	880:900	Body-weight, visceral fat mass, tail skin temperature, serum 17β-estradiol, glucose intolerance, and insulin tolerance were determined.
32910260	8	77	theme	feces	1267:1271	arg1	incubation					1249:1258	the incubation	1245:1258	the incubation of rat feces with these two prebiotics in vitro	1245:1306	RESULTS Chitosan and citrus pectin were selected because the incubation of rat feces with these two prebiotics in vitro had shown increased butyrate production.
32910260	2	78	theme	citrus	402:407	arg1	pectin					409:414	citrus pectin	402:414	citrus pectin	402:414	The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can improve postmenopausal symptoms, possibly by modulating the gut microbiota in ovariectomized (OVX) rats, and the mechanism of action was examined.
32910260	14	79	theme	Metabolomic	2011:2021	arg1	analysis					2023:2030	Metabolomic analysis	2011:2030	Metabolomic analysis	2011:2030	Metabolomic analysis revealed higher serum urate concentrations in the OVX-Control group than the other groups, and serum arginine and leucine concentrations were higher in the OVX-Chitosan group (P < 0.05).
32910260	6	80	theme	Gut	984:986	arg1	microbiota					988:997	Gut microbiota	984:997	Gut microbiota in the fecal samples	984:1018	Gut microbiota in the fecal samples was measured by NGS and analyzed with PICRUSt2.
32910260	14	81	theme	other	2109:2113	arg1	groups					2115:2120	the other groups	2105:2120	the other groups	2105:2120	Metabolomic analysis revealed higher serum urate concentrations in the OVX-Control group than the other groups, and serum arginine and leucine concentrations were higher in the OVX-Chitosan group (P < 0.05).
32910260	7	82	theme	Short-chain	1068:1078	arg1	SCFA					1093:1096	SCFA	1093:1096	SCFA	1093:1096	Short-chain fatty acids (SCFA) and metabolomic characteristics of serum were also measured with UPLC-mass spectrometry.
32910260	7	82	theme	Short-chain	1068:1078	arg1	acids					1086:1090	Short-chain fatty acids	1068:1090	Short-chain fatty acids (SCFA)	1068:1097	Short-chain fatty acids (SCFA) and metabolomic characteristics of serum were also measured with UPLC-mass spectrometry.
32910260	5	83	theme	fat	870:872	arg1	mass					874:877	Body-weight, visceral fat mass	848:877	Body-weight, visceral fat mass	848:877	Body-weight, visceral fat mass, tail skin temperature, serum 17β-estradiol, glucose intolerance, and insulin tolerance were determined.
32910260	9	84	theme	glucose	1472:1478	arg1	tolerance					1480:1488	glucose tolerance	1472:1488	glucose tolerance	1472:1488	OVX-Chitosan reduced the weight, visceral fat content, and tail skin temperature, and OVX-Chitosan and OVX-Pectin improved glucose tolerance, compared to the OVX-Control.
32910260	11	85	theme	butyrate	1637:1644	arg1	concentrations					1646:1659	serum propionate and butyrate concentrations	1616:1659	concentrations	1646:1659	OVX-Chitosan and OVX-Pectin elevated serum propionate and butyrate concentrations but only OVX-Chitosan lowered serum acetate concentrations.
32910260	2	86	theme	postmenopausal	428:441	arg1	symptoms					443:450	postmenopausal symptoms	428:450	postmenopausal symptoms	428:450	The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can improve postmenopausal symptoms, possibly by modulating the gut microbiota in ovariectomized (OVX) rats, and the mechanism of action was examined.
32910260	5	87	theme	glucose	924:930	arg1	intolerance					932:942	glucose intolerance	924:942	glucose intolerance	924:942	Body-weight, visceral fat mass, tail skin temperature, serum 17β-estradiol, glucose intolerance, and insulin tolerance were determined.
32910260	14	88	theme	OVX-Control	2082:2092	arg1	group					2094:2098	the OVX-Control group	2078:2098	the OVX-Control group	2078:2098	Metabolomic analysis revealed higher serum urate concentrations in the OVX-Control group than the other groups, and serum arginine and leucine concentrations were higher in the OVX-Chitosan group (P < 0.05).
32910260	0	89	theme	gut	58:60	arg1	microbiota					62:71	the gut microbiota	54:71	the gut microbiota in estrogen-deficient rats	54:98	Chitosan alleviated menopausal symptoms and modulated the gut microbiota in estrogen-deficient rats.
32910260	11	90	theme	OVX-Chitosan	1670:1681	arg1	concentrations					1705:1718	OVX-Chitosan lowered serum acetate concentrations	1670:1718	serum propionate and butyrate concentrations but only OVX-Chitosan lowered serum acetate concentrations	1616:1718	OVX-Chitosan and OVX-Pectin elevated serum propionate and butyrate concentrations but only OVX-Chitosan lowered serum acetate concentrations.
32910260	12	91	theme	microbiota	1783:1792	arg1	genes					1770:1774	the functional genes	1755:1774	the functional genes of gut microbiota involved in valine, leucine, and isoleucine biosynthesis	1755:1849	In PICRUSt2, chitosan upregulated the functional genes of gut microbiota involved in valine, leucine, and isoleucine biosynthesis, whereas the OVX-Control exhibited significantly upregulated lipopolysaccharide biosynthesis.
32910260	14	92	theme	urate	2054:2058	arg1	concentrations					2060:2073	serum urate concentrations	2048:2073	serum urate concentrations	2048:2073	Metabolomic analysis revealed higher serum urate concentrations in the OVX-Control group than the other groups, and serum arginine and leucine concentrations were higher in the OVX-Chitosan group (P < 0.05).
32910260	8	93	theme	butyrate	1328:1335	arg1	production					1337:1346	increased butyrate production	1318:1346	increased butyrate production	1318:1346	RESULTS Chitosan and citrus pectin were selected because the incubation of rat feces with these two prebiotics in vitro had shown increased butyrate production.
32910260	13	94	theme	fecal	1995:1999	arg1	bacteria					2001:2008	the fecal bacteria	1991:2008	the fecal bacteria	1991:2008	OVX-Pectin exhibited increased α-diversity in the fecal bacteria.
32910260	2	95	theme	study	336:340	arg1	objective					311:319	The objective	307:319	The objective of the present study	307:340	The objective of the present study was to assess whether consuming the prebiotics chitosan and citrus pectin can improve postmenopausal symptoms, possibly by modulating the gut microbiota in ovariectomized (OVX) rats, and the mechanism of action was examined.
32910260	1	96	theme	dietary	222:228	arg1	fibers					230:235	dietary fibers	222:235	dietary fibers without phytoestrogens	222:258	PURPOSE Menopause disturbs energy, glucose, and lipid metabolisms and changes the composition of the gut microbiota, but dietary fibers without phytoestrogens may ameliorate menopausal metabolic disorders.
32910260	16	97	theme	menopausal	2471:2480	arg1	symptoms					2482:2489	menopausal symptoms	2471:2489	menopausal symptoms	2471:2489	Chitosan was more effective for improving menopausal symptoms than citrus pectin.
32910260	15	98	theme	microbiota	2353:2362	arg1	SCFA					2391:2394	SCFA	2391:2394	SCFA	2391:2394	CONCLUSION Chitosan and citrus pectin consumptions improved menopausal symptoms by improving the diversity and composition of the gut microbiota, and serum metabolites and SCFA originating from fecal bacteria.
32910260	15	98	theme	microbiota	2353:2362	arg1	metabolites					2375:2385	serum metabolites	2369:2385	serum metabolites	2369:2385	CONCLUSION Chitosan and citrus pectin consumptions improved menopausal symptoms by improving the diversity and composition of the gut microbiota, and serum metabolites and SCFA originating from fecal bacteria.
32910260	15	98	theme	microbiota	2353:2362	arg1	composition					2330:2340	composition	2330:2340	composition	2330:2340	CONCLUSION Chitosan and citrus pectin consumptions improved menopausal symptoms by improving the diversity and composition of the gut microbiota, and serum metabolites and SCFA originating from fecal bacteria.
32910260	15	98	theme	microbiota	2353:2362	arg1	diversity					2316:2324	diversity	2316:2324	diversity	2316:2324	CONCLUSION Chitosan and citrus pectin consumptions improved menopausal symptoms by improving the diversity and composition of the gut microbiota, and serum metabolites and SCFA originating from fecal bacteria.
32653642	5	0	theme	matrix	785:790	arg1	rings					792:796	CSPG-5-containing perisynaptic matrix rings	754:796	CSPG-5-containing perisynaptic matrix rings	754:796	CSPG-5-containing perisynaptic matrix rings often appear at the peripheral margin of perineuronal nets.
32653642	8	1	theme	CSPG-5	1240:1245	arg1	expression					1247:1256	CSPG-5 expression	1240:1256	CSPG-5 expression	1240:1256	In human subjects, CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.
32653642	3	2	with	regions	474:480	arg1	properties					495:504	plastic properties	487:504	plastic properties	487:504	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	2	3	theme	forming	350:356	arg1	synapse					342:348	synapse forming	342:356	synapse forming	342:356	Chondroitin sulfate proteoglycan 5 (CSPG-5), also known as neuroglycan C, has been previously associated to differentiation since it shapes neurite growth and synapse forming.
32653642	0	4	theme	rat	85:87	arg1	cortex					89:94	the adult rat cortex	75:94	the adult rat cortex	75:94	Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.
32653642	7	5	theme	transfected	1139:1149	arg1	cells					1165:1169	transfected neuroblastoma cells	1139:1169	transfected neuroblastoma cells	1139:1169	In vitro analyses suggest that neurons, but less so astrocytes, express CSPG-5 in rat primary neocortical cultures, and CSPG-5 produced by transfected neuroblastoma cells appear at endings and contact points of neurites.
32653642	4	6	theme	glutamatergic	680:692	arg1	terminals					708:716	glutamatergic and GABAergic terminals	680:716	glutamatergic and GABAergic terminals in twelve-week old rat hippocampus	680:751	Progressively accumulating after birth, CSPG-5 typically concentrates around glutamatergic and GABAergic terminals in twelve-week old rat hippocampus.
32653642	6	7	theme	synaptosomal	894:905	arg1	fraction					907:914	synaptosomal fraction	894:914	synaptosomal fraction	894:914	Electron microscopy and analysis of synaptosomal fraction showed that CSPG-5 accumulates around, and is associated to synapses, respectively.
32653642	7	8	theme	In	1000:1001	arg1	analyses					1009:1016	In vitro analyses	1000:1016	In vitro analyses	1000:1016	In vitro analyses suggest that neurons, but less so astrocytes, express CSPG-5 in rat primary neocortical cultures, and CSPG-5 produced by transfected neuroblastoma cells appear at endings and contact points of neurites.
32653642	4	9	theme	rat	737:739	arg1	hippocampus					741:751	twelve-week old rat hippocampus	721:751	twelve-week old rat hippocampus	721:751	Progressively accumulating after birth, CSPG-5 typically concentrates around glutamatergic and GABAergic terminals in twelve-week old rat hippocampus.
32653642	4	10	theme	twelve-week	721:731	arg1	hippocampus					741:751	twelve-week old rat hippocampus	721:751	twelve-week old rat hippocampus	721:751	Progressively accumulating after birth, CSPG-5 typically concentrates around glutamatergic and GABAergic terminals in twelve-week old rat hippocampus.
32653642	8	11	theme	network	1300:1306	arg1	areas					1274:1278	brain areas	1268:1278	brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power	1268:1426	In human subjects, CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.
32653642	8	12	theme	mode	1295:1298	arg1	network					1300:1306	the default mode network	1283:1306	the default mode network	1283:1306	In human subjects, CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.
32653642	3	13	theme	rat	422:424	arg1	brain					426:430	the postnatal rat brain	408:430	the postnatal rat brain	408:430	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	7	14	theme	neurites	1211:1218	arg1	endings					1181:1187	endings	1181:1187	endings	1181:1187	In vitro analyses suggest that neurons, but less so astrocytes, express CSPG-5 in rat primary neocortical cultures, and CSPG-5 produced by transfected neuroblastoma cells appear at endings and contact points of neurites.
32653642	7	14	theme	neurites	1211:1218	arg1	points					1201:1206	contact points	1193:1206	contact points	1193:1206	In vitro analyses suggest that neurons, but less so astrocytes, express CSPG-5 in rat primary neocortical cultures, and CSPG-5 produced by transfected neuroblastoma cells appear at endings and contact points of neurites.
32653642	4	15	dep	concentrates	660:671	arg1	accumulating					617:628	accumulating	617:628	accumulating	617:628	Progressively accumulating after birth, CSPG-5 typically concentrates around glutamatergic and GABAergic terminals in twelve-week old rat hippocampus.
32653642	5	16	theme	peripheral	818:827	arg1	margin					829:834	the peripheral margin	814:834	the peripheral margin of perineuronal nets	814:855	CSPG-5-containing perisynaptic matrix rings often appear at the peripheral margin of perineuronal nets.
32653642	6	17	theme	fraction	907:914	arg1	analysis					882:889	analysis	882:889	analysis of synaptosomal fraction	882:914	Electron microscopy and analysis of synaptosomal fraction showed that CSPG-5 accumulates around, and is associated to synapses, respectively.
32653642	6	17	theme	fraction	907:914	arg1	microscopy					867:876	Electron microscopy	858:876	Electron microscopy	858:876	Electron microscopy and analysis of synaptosomal fraction showed that CSPG-5 accumulates around, and is associated to synapses, respectively.
32653642	7	18	theme	neocortical	1094:1104	arg1	cultures					1106:1113	rat primary neocortical cultures	1082:1113	rat primary neocortical cultures	1082:1113	In vitro analyses suggest that neurons, but less so astrocytes, express CSPG-5 in rat primary neocortical cultures, and CSPG-5 produced by transfected neuroblastoma cells appear at endings and contact points of neurites.
32653642	5	19	theme	CSPG-5-containing	754:770	arg1	rings					792:796	CSPG-5-containing perisynaptic matrix rings	754:796	CSPG-5-containing perisynaptic matrix rings	754:796	CSPG-5-containing perisynaptic matrix rings often appear at the peripheral margin of perineuronal nets.
32653642	3	20	theme	prefrontal	544:553	arg1	cortex					555:560	the medial prefrontal cortex	533:560	the medial prefrontal cortex	533:560	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	8	21	theme	brain	1268:1272	arg1	areas					1274:1278	brain areas	1268:1278	brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power	1268:1426	In human subjects, CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.
32653642	0	22	theme	Chondroitin	0:10	arg1	sulfate					12:18	Chondroitin sulfate proteoglycan-5	0:33	Chondroitin sulfate proteoglycan-5	0:33	Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.
32653642	4	23	theme	old	733:735	arg1	hippocampus					741:751	twelve-week old rat hippocampus	721:751	twelve-week old rat hippocampus	721:751	Progressively accumulating after birth, CSPG-5 typically concentrates around glutamatergic and GABAergic terminals in twelve-week old rat hippocampus.
32653642	3	24	theme	postnatal	412:420	arg1	brain					426:430	the postnatal rat brain	408:430	the postnatal rat brain	408:430	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	8	25	theme	suicide	1311:1317	arg1	victims					1319:1325	suicide victims	1311:1325	suicide victims	1311:1325	In human subjects, CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.
32653642	7	26	theme	rat	1082:1084	arg1	cultures					1106:1113	rat primary neocortical cultures	1082:1113	rat primary neocortical cultures	1082:1113	In vitro analyses suggest that neurons, but less so astrocytes, express CSPG-5 in rat primary neocortical cultures, and CSPG-5 produced by transfected neuroblastoma cells appear at endings and contact points of neurites.
32653642	8	27	theme	psychiatric	1379:1389	arg1	diseases					1391:1398	psychiatric diseases	1379:1398	psychiatric diseases	1379:1398	In human subjects, CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.
32653642	5	28	theme	nets	852:855	arg1	margin					829:834	the peripheral margin	814:834	the peripheral margin of perineuronal nets	814:855	CSPG-5-containing perisynaptic matrix rings often appear at the peripheral margin of perineuronal nets.
32653642	5	29	theme	perineuronal	839:850	arg1	nets					852:855	perineuronal nets	839:855	perineuronal nets	839:855	CSPG-5-containing perisynaptic matrix rings often appear at the peripheral margin of perineuronal nets.
32653642	7	30	theme	primary	1086:1092	arg1	cultures					1106:1113	rat primary neocortical cultures	1082:1113	rat primary neocortical cultures	1082:1113	In vitro analyses suggest that neurons, but less so astrocytes, express CSPG-5 in rat primary neocortical cultures, and CSPG-5 produced by transfected neuroblastoma cells appear at endings and contact points of neurites.
32653642	2	31	theme	sulfate	195:201	arg1	proteoglycan					203:214	Chondroitin sulfate proteoglycan 5	183:216	Chondroitin sulfate proteoglycan 5 (CSPG-5)	183:225	Chondroitin sulfate proteoglycan 5 (CSPG-5), also known as neuroglycan C, has been previously associated to differentiation since it shapes neurite growth and synapse forming.
32653642	2	31	theme	sulfate	195:201	arg1	CSPG-5					219:224	CSPG-5	219:224	CSPG-5	219:224	Chondroitin sulfate proteoglycan 5 (CSPG-5), also known as neuroglycan C, has been previously associated to differentiation since it shapes neurite growth and synapse forming.
32653642	3	32	theme	medial	537:542	arg1	cortex					555:560	the medial prefrontal cortex	533:560	the medial prefrontal cortex	533:560	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	3	33	from	end	569:571	arg1	hippocampus					517:527	hippocampus	517:527	hippocampus	517:527	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	3	33	from	end	569:571	arg1	cortex					555:560	the medial prefrontal cortex	533:560	the medial prefrontal cortex	533:560	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	0	34	theme	matrix	54:59	arg1	assemblies					61:70	perisynaptic matrix assemblies	41:70	perisynaptic matrix assemblies	41:70	Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.
32653642	3	35	theme	cortical	465:472	arg1	hippocampus					517:527	hippocampus	517:527	hippocampus	517:527	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	3	35	theme	cortical	465:472	arg1	regions					474:480	cortical regions	465:480	cortical regions	465:480	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	3	35	theme	cortical	465:472	arg1	cortex					555:560	the medial prefrontal cortex	533:560	the medial prefrontal cortex	533:560	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	2	36	theme	Chondroitin	183:193	arg1	proteoglycan					203:214	Chondroitin sulfate proteoglycan 5	183:216	Chondroitin sulfate proteoglycan 5 (CSPG-5)	183:225	Chondroitin sulfate proteoglycan 5 (CSPG-5), also known as neuroglycan C, has been previously associated to differentiation since it shapes neurite growth and synapse forming.
32653642	2	36	theme	Chondroitin	183:193	arg1	CSPG-5					219:224	CSPG-5	219:224	CSPG-5	219:224	Chondroitin sulfate proteoglycan 5 (CSPG-5), also known as neuroglycan C, has been previously associated to differentiation since it shapes neurite growth and synapse forming.
32653642	8	37	theme	default	1287:1293	arg1	network					1300:1306	the default mode network	1283:1306	the default mode network	1283:1306	In human subjects, CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.
32653642	0	38	theme	perisynaptic	41:52	arg1	assemblies					61:70	perisynaptic matrix assemblies	41:70	perisynaptic matrix assemblies	41:70	Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.
32653642	8	39	theme	human	1224:1228	arg1	subjects					1230:1237	human subjects	1224:1237	human subjects	1224:1237	In human subjects, CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.
32653642	8	40	theme	diseases	1391:1398	arg1	pathogenesis					1363:1374	the pathogenesis	1359:1374	the pathogenesis of psychiatric diseases	1359:1398	In human subjects, CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.
32653642	7	41	theme	neuroblastoma	1151:1163	arg1	cells					1165:1169	transfected neuroblastoma cells	1139:1169	transfected neuroblastoma cells	1139:1169	In vitro analyses suggest that neurons, but less so astrocytes, express CSPG-5 in rat primary neocortical cultures, and CSPG-5 produced by transfected neuroblastoma cells appear at endings and contact points of neurites.
32653642	8	42	theme	diagnostic	1411:1420	arg1	power					1422:1426	diagnostic power	1411:1426	diagnostic power	1411:1426	In human subjects, CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.
32653642	1	43	theme	brain	116:120	arg1	matrix					136:141	the brain extracellular matrix	112:141	the brain extracellular matrix	112:141	Composition of the brain extracellular matrix changes in time as maturation proceeds.
32653642	1	44	theme	extracellular	122:134	arg1	matrix					136:141	the brain extracellular matrix	112:141	the brain extracellular matrix	112:141	Composition of the brain extracellular matrix changes in time as maturation proceeds.
32653642	6	45	theme	Electron	858:865	arg1	microscopy					867:876	Electron microscopy	858:876	Electron microscopy	858:876	Electron microscopy and analysis of synaptosomal fraction showed that CSPG-5 accumulates around, and is associated to synapses, respectively.
32653642	3	46	theme	postnatal	587:595	arg1	week					597:600	the second postnatal week	576:600	the second postnatal week	576:600	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	1	47	theme	matrix	136:141	arg1	Composition					97:107	Composition	97:107	Composition of the brain extracellular matrix	97:141	Composition of the brain extracellular matrix changes in time as maturation proceeds.
32653642	3	48	theme	week	597:600	arg1	end					569:571	the end	565:571	the end of the second postnatal week	565:600	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	8	49	theme	victims	1319:1325	arg1	network					1300:1306	the default mode network	1283:1306	the default mode network	1283:1306	In human subjects, CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power.
32653642	4	50	from	terminals	708:716	arg1	hippocampus					741:751	twelve-week old rat hippocampus	721:751	twelve-week old rat hippocampus	721:751	Progressively accumulating after birth, CSPG-5 typically concentrates around glutamatergic and GABAergic terminals in twelve-week old rat hippocampus.
32653642	2	51	theme	neurite	323:329	arg1	growth					331:336	neurite growth	323:336	neurite growth	323:336	Chondroitin sulfate proteoglycan 5 (CSPG-5), also known as neuroglycan C, has been previously associated to differentiation since it shapes neurite growth and synapse forming.
32653642	0	52	theme	adult	79:83	arg1	cortex					89:94	the adult rat cortex	75:94	the adult rat cortex	75:94	Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.
32653642	2	53	theme	neuroglycan	242:252	arg1	C					254:254	neuroglycan C	242:254	neuroglycan C	242:254	Chondroitin sulfate proteoglycan 5 (CSPG-5), also known as neuroglycan C, has been previously associated to differentiation since it shapes neurite growth and synapse forming.
32653642	3	54	theme	plastic	487:493	arg1	properties					495:504	plastic properties	487:504	plastic properties	487:504	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	7	55	dep	In	1000:1001	arg1	vitro					1003:1007	vitro	1003:1007	vitro	1003:1007	In vitro analyses suggest that neurons, but less so astrocytes, express CSPG-5 in rat primary neocortical cultures, and CSPG-5 produced by transfected neuroblastoma cells appear at endings and contact points of neurites.
32653642	5	56	theme	perisynaptic	772:783	arg1	rings					792:796	CSPG-5-containing perisynaptic matrix rings	754:796	CSPG-5-containing perisynaptic matrix rings	754:796	CSPG-5-containing perisynaptic matrix rings often appear at the peripheral margin of perineuronal nets.
32653642	3	57	theme	second	580:585	arg1	week					597:600	the second postnatal week	576:600	the second postnatal week	576:600	Here, we show that this proteoglycan persists in the postnatal rat brain, and its expression is higher in cortical regions with plastic properties, including hippocampus and the medial prefrontal cortex at the end of the second postnatal week.
32653642	7	58	theme	contact	1193:1199	arg1	points					1201:1206	contact points	1193:1206	contact points	1193:1206	In vitro analyses suggest that neurons, but less so astrocytes, express CSPG-5 in rat primary neocortical cultures, and CSPG-5 produced by transfected neuroblastoma cells appear at endings and contact points of neurites.
32653642	4	59	theme	GABAergic	698:706	arg1	terminals					708:716	glutamatergic and GABAergic terminals	680:716	glutamatergic and GABAergic terminals in twelve-week old rat hippocampus	680:751	Progressively accumulating after birth, CSPG-5 typically concentrates around glutamatergic and GABAergic terminals in twelve-week old rat hippocampus.
32470578	0	0	theme	wound	107:111	arg1	dressing					113:120	novel wound dressing	101:120	novel wound dressing	101:120	Batch preparation of electrospun polycaprolactone/chitosan/aloe vera blended nanofiber membranes for novel wound dressing.
32470578	8	1	theme	fabricated	1418:1427	arg1	NFMs					1429:1432	the fabricated NFMs	1414:1432	the fabricated NFMs	1414:1432	The results illustrated SFSE could prepare high quality PCL/CS/AV NFMs in batches, and its yield of PCL/CS/AV NFMs was 10 times more than the single-needle ES, and the fabricated NFMs showed excellent antibacterial performance and biocompatibility, which made them suitable for wound dressings.
32470578	3	2	theme	PCL/CS/AV	487:495	arg1	NFMs					519:522	NFMs	519:522	NFMs	519:522	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	3	2	theme	PCL/CS/AV	487:495	arg1	membranes					508:516	polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes	450:516	polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs)	450:523	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	0	3	theme	novel	101:105	arg1	dressing					113:120	novel wound dressing	101:120	novel wound dressing	101:120	Batch preparation of electrospun polycaprolactone/chitosan/aloe vera blended nanofiber membranes for novel wound dressing.
32470578	6	4	theme	SFSE	1020:1023	arg1	mechanism					1007:1015	the preparation mechanism	991:1015	the preparation mechanism of SFSE	991:1023	In addition, the preparation mechanism of SFSE was researched by simulating the electric field distribution using Maxwell 3D due to the important role of the electric field in the SFSE process.
32470578	8	5	theme	wound	1528:1532	arg1	dressings					1534:1542	wound dressings	1528:1542	wound dressings	1528:1542	The results illustrated SFSE could prepare high quality PCL/CS/AV NFMs in batches, and its yield of PCL/CS/AV NFMs was 10 times more than the single-needle ES, and the fabricated NFMs showed excellent antibacterial performance and biocompatibility, which made them suitable for wound dressings.
32470578	8	6	theme	high	1293:1296	arg1	NFMs					1316:1319	high quality PCL/CS/AV NFMs	1293:1319	high quality PCL/CS/AV NFMs in batches	1293:1330	The results illustrated SFSE could prepare high quality PCL/CS/AV NFMs in batches, and its yield of PCL/CS/AV NFMs was 10 times more than the single-needle ES, and the fabricated NFMs showed excellent antibacterial performance and biocompatibility, which made them suitable for wound dressings.
32470578	4	7	theme	wound	726:730	arg1	dressings					732:740	better wound dressings	719:740	better wound dressings	719:740	And the morphologies of PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV were studied using SEM, and the optimal weight ratio of 5:3:2 was determined for better wound dressings.
32470578	3	8	theme	free	362:365	arg1	device					398:403	a slopeing free surface electrospinning (SFSE) device	351:403	a slopeing free surface electrospinning (SFSE) device	351:403	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	5	9	theme	addition	884:891	arg1	effects					869:875	the effects	865:875	the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs	865:963	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	5	10	theme	antibacterial	906:918	arg1	performance					920:930	the antibacterial performance	902:930	the antibacterial performance	902:930	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	5	11	dep	structure	752:760	arg1	the					748:750	the	748:750	the	748:750	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	5	12	theme	weight	829:834	arg1	ratio					836:840	the optimal weight ratio	817:840	the optimal weight ratio	817:840	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	3	13	theme	polycaprolactone/chitosan/aloe	450:479	arg1	NFMs					519:522	NFMs	519:522	NFMs	519:522	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	3	13	theme	polycaprolactone/chitosan/aloe	450:479	arg1	membranes					508:516	polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes	450:516	polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs)	450:523	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	3	14	theme	vera	481:484	arg1	NFMs					519:522	NFMs	519:522	NFMs	519:522	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	3	14	theme	vera	481:484	arg1	membranes					508:516	polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes	450:516	polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs)	450:523	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	4	15	theme	weight	611:616	arg1	ratios					618:623	varying weight ratios	603:623	varying weight ratios of PCL:CS:AV	603:636	And the morphologies of PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV were studied using SEM, and the optimal weight ratio of 5:3:2 was determined for better wound dressings.
32470578	4	16	theme	better	719:724	arg1	dressings					732:740	better wound dressings	719:740	better wound dressings	719:740	And the morphologies of PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV were studied using SEM, and the optimal weight ratio of 5:3:2 was determined for better wound dressings.
32470578	8	17	theme	quality	1298:1304	arg1	NFMs					1316:1319	high quality PCL/CS/AV NFMs	1293:1319	high quality PCL/CS/AV NFMs in batches	1293:1330	The results illustrated SFSE could prepare high quality PCL/CS/AV NFMs in batches, and its yield of PCL/CS/AV NFMs was 10 times more than the single-needle ES, and the fabricated NFMs showed excellent antibacterial performance and biocompatibility, which made them suitable for wound dressings.
32470578	6	18	theme	preparation	995:1005	arg1	mechanism					1007:1015	the preparation mechanism	991:1015	the preparation mechanism of SFSE	991:1023	In addition, the preparation mechanism of SFSE was researched by simulating the electric field distribution using Maxwell 3D due to the important role of the electric field in the SFSE process.
32470578	6	19	from	role	1124:1127	arg1	process					1163:1169	the SFSE process	1154:1169	the SFSE process	1154:1169	In addition, the preparation mechanism of SFSE was researched by simulating the electric field distribution using Maxwell 3D due to the important role of the electric field in the SFSE process.
32470578	6	20	theme	field	1067:1071	arg1	distribution					1073:1084	the electric field distribution	1054:1084	the electric field distribution using Maxwell 3D	1054:1101	In addition, the preparation mechanism of SFSE was researched by simulating the electric field distribution using Maxwell 3D due to the important role of the electric field in the SFSE process.
32470578	2	21	theme	good	265:268	arg1	biocompatibility					270:285	good biocompatibility	265:285	good biocompatibility	265:285	Chitosan, a kind of carbohydrate polymer with good biocompatibility, is widely used in the field of wound dressings.
32470578	8	22	from	NFMs	1316:1319	arg1	batches					1324:1330	batches	1324:1330	batches	1324:1330	The results illustrated SFSE could prepare high quality PCL/CS/AV NFMs in batches, and its yield of PCL/CS/AV NFMs was 10 times more than the single-needle ES, and the fabricated NFMs showed excellent antibacterial performance and biocompatibility, which made them suitable for wound dressings.
32470578	5	23	theme	PCL/CS/AV	797:805	arg1	NFMs					807:810	the PCL/CS/AV NFMs	793:810	the PCL/CS/AV NFMs with the optimal weight ratio	793:840	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	3	24	theme	slopeing	353:360	arg1	device					398:403	a slopeing free surface electrospinning (SFSE) device	351:403	a slopeing free surface electrospinning (SFSE) device	351:403	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	8	25	theme	antibacterial	1451:1463	arg1	performance					1465:1475	excellent antibacterial performance	1441:1475	excellent antibacterial performance	1441:1475	The results illustrated SFSE could prepare high quality PCL/CS/AV NFMs in batches, and its yield of PCL/CS/AV NFMs was 10 times more than the single-needle ES, and the fabricated NFMs showed excellent antibacterial performance and biocompatibility, which made them suitable for wound dressings.
32470578	6	26	theme	SFSE	1158:1161	arg1	process					1163:1169	the SFSE process	1154:1169	the SFSE process	1154:1169	In addition, the preparation mechanism of SFSE was researched by simulating the electric field distribution using Maxwell 3D due to the important role of the electric field in the SFSE process.
32470578	7	27	theme	simulation	1176:1185	arg1	analyses					1187:1194	The simulation analyses	1172:1194	The simulation analyses of electric fields	1172:1213	The simulation analyses of electric fields agreed with the experimental data.
32470578	5	28	theme	NFMs	807:810	arg1	yield					784:788	yield	784:788	yield	784:788	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	5	28	theme	NFMs	807:810	arg1	structure					752:760	structure	752:760	structure	752:760	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	5	28	theme	NFMs	807:810	arg1	property					771:778	wetting property	763:778	wetting property	763:778	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	0	29	theme	Batch	0:4	arg1	preparation					6:16	Batch preparation	0:16	Batch preparation of electrospun polycaprolactone/chitosan/aloe vera	0:67	Batch preparation of electrospun polycaprolactone/chitosan/aloe vera blended nanofiber membranes for novel wound dressing.
32470578	8	30	theme	excellent	1441:1449	arg1	performance					1465:1475	excellent antibacterial performance	1441:1475	excellent antibacterial performance	1441:1475	The results illustrated SFSE could prepare high quality PCL/CS/AV NFMs in batches, and its yield of PCL/CS/AV NFMs was 10 times more than the single-needle ES, and the fabricated NFMs showed excellent antibacterial performance and biocompatibility, which made them suitable for wound dressings.
32470578	8	31	theme	more	1378:1381	arg1	times					1372:1376	10 times	1369:1376	10 times more than the single-needle ES	1369:1407	The results illustrated SFSE could prepare high quality PCL/CS/AV NFMs in batches, and its yield of PCL/CS/AV NFMs was 10 times more than the single-needle ES, and the fabricated NFMs showed excellent antibacterial performance and biocompatibility, which made them suitable for wound dressings.
32470578	4	32	theme	weight	678:683	arg1	ratio					685:689	the optimal weight ratio	666:689	the optimal weight ratio of 5:3:2	666:698	And the morphologies of PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV were studied using SEM, and the optimal weight ratio of 5:3:2 was determined for better wound dressings.
32470578	7	33	theme	electric	1199:1206	arg1	fields					1208:1213	electric fields	1199:1213	electric fields	1199:1213	The simulation analyses of electric fields agreed with the experimental data.
32470578	7	34	theme	experimental	1231:1242	arg1	data					1244:1247	the experimental data	1227:1247	the experimental data	1227:1247	The simulation analyses of electric fields agreed with the experimental data.
32470578	0	35	theme	electrospun	21:31	arg1	vera					64:67	electrospun polycaprolactone/chitosan/aloe vera	21:67	electrospun polycaprolactone/chitosan/aloe vera	21:67	Batch preparation of electrospun polycaprolactone/chitosan/aloe vera blended nanofiber membranes for novel wound dressing.
32470578	6	36	theme	important	1114:1122	arg1	role					1124:1127	the important role	1110:1127	the important role of the electric field in the SFSE process	1110:1169	In addition, the preparation mechanism of SFSE was researched by simulating the electric field distribution using Maxwell 3D due to the important role of the electric field in the SFSE process.
32470578	8	37	dep	showed	1434:1439	arg1	made					1505:1508	made	1505:1508	made them suitable for wound dressings	1505:1542	The results illustrated SFSE could prepare high quality PCL/CS/AV NFMs in batches, and its yield of PCL/CS/AV NFMs was 10 times more than the single-needle ES, and the fabricated NFMs showed excellent antibacterial performance and biocompatibility, which made them suitable for wound dressings.
32470578	3	38	theme	antibacterial	529:541	arg1	dressing					549:556	antibacterial wound dressing	529:556	antibacterial wound dressing	529:556	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	1	39	theme	active	195:200	arg1	dressings					208:216	active wound dressings	195:216	active wound dressings	195:216	At present, more and more attention has been paid to the development of active wound dressings.
32470578	5	40	theme	wetting	763:769	arg1	property					771:778	wetting property	763:778	wetting property	763:778	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	2	41	with	kind	231:234	arg1	biocompatibility					270:285	good biocompatibility	265:285	good biocompatibility	265:285	Chitosan, a kind of carbohydrate polymer with good biocompatibility, is widely used in the field of wound dressings.
32470578	5	42	theme	AV	896:897	arg1	addition					884:891	the addition	880:891	the addition of AV	880:897	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	8	43	theme	PCL/CS/AV	1350:1358	arg1	NFMs					1360:1363	PCL/CS/AV NFMs	1350:1363	PCL/CS/AV NFMs	1350:1363	The results illustrated SFSE could prepare high quality PCL/CS/AV NFMs in batches, and its yield of PCL/CS/AV NFMs was 10 times more than the single-needle ES, and the fabricated NFMs showed excellent antibacterial performance and biocompatibility, which made them suitable for wound dressings.
32470578	3	44	theme	wound	543:547	arg1	dressing					549:556	antibacterial wound dressing	529:556	antibacterial wound dressing	529:556	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	1	45	theme	wound	202:206	arg1	dressings					208:216	active wound dressings	195:216	active wound dressings	195:216	At present, more and more attention has been paid to the development of active wound dressings.
32470578	0	46	theme	vera	64:67	arg1	preparation					6:16	Batch preparation	0:16	Batch preparation of electrospun polycaprolactone/chitosan/aloe vera	0:67	Batch preparation of electrospun polycaprolactone/chitosan/aloe vera blended nanofiber membranes for novel wound dressing.
32470578	2	47	theme	wound	319:323	arg1	dressings					325:333	wound dressings	319:333	wound dressings	319:333	Chitosan, a kind of carbohydrate polymer with good biocompatibility, is widely used in the field of wound dressings.
32470578	6	48	theme	electric	1136:1143	arg1	field					1145:1149	the electric field	1132:1149	the electric field	1132:1149	In addition, the preparation mechanism of SFSE was researched by simulating the electric field distribution using Maxwell 3D due to the important role of the electric field in the SFSE process.
32470578	4	49	theme	PCL	628:630	arg1	ratios					618:623	varying weight ratios	603:623	varying weight ratios of PCL:CS:AV	603:636	And the morphologies of PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV were studied using SEM, and the optimal weight ratio of 5:3:2 was determined for better wound dressings.
32470578	4	50	dep	PCL	628:630	arg1	CS					632:633	CS	632:633	PCL:CS:AV	628:636	And the morphologies of PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV were studied using SEM, and the optimal weight ratio of 5:3:2 was determined for better wound dressings.
32470578	4	50	dep	PCL	628:630	arg1	AV					635:636	AV	635:636	PCL:CS:AV	628:636	And the morphologies of PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV were studied using SEM, and the optimal weight ratio of 5:3:2 was determined for better wound dressings.
32470578	7	51	theme	fields	1208:1213	arg1	analyses					1187:1194	The simulation analyses	1172:1194	The simulation analyses of electric fields	1172:1213	The simulation analyses of electric fields agreed with the experimental data.
32470578	1	52	theme	dressings	208:216	arg1	development					180:190	the development	176:190	the development of active wound dressings	176:216	At present, more and more attention has been paid to the development of active wound dressings.
32470578	0	53	theme	polycaprolactone/chitosan/aloe	33:62	arg1	vera					64:67	electrospun polycaprolactone/chitosan/aloe vera	21:67	electrospun polycaprolactone/chitosan/aloe vera	21:67	Batch preparation of electrospun polycaprolactone/chitosan/aloe vera blended nanofiber membranes for novel wound dressing.
32470578	3	54	theme	SFSE	392:395	arg1	device					398:403	a slopeing free surface electrospinning (SFSE) device	351:403	a slopeing free surface electrospinning (SFSE) device	351:403	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	6	55	theme	field	1145:1149	arg1	role					1124:1127	the important role	1110:1127	the important role of the electric field in the SFSE process	1110:1169	In addition, the preparation mechanism of SFSE was researched by simulating the electric field distribution using Maxwell 3D due to the important role of the electric field in the SFSE process.
32470578	4	56	theme	5:3:2	694:698	arg1	ratio					685:689	the optimal weight ratio	666:689	the optimal weight ratio of 5:3:2	666:698	And the morphologies of PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV were studied using SEM, and the optimal weight ratio of 5:3:2 was determined for better wound dressings.
32470578	0	57	theme	nanofiber	77:85	arg1	membranes					87:95	nanofiber membranes	77:95	nanofiber membranes	77:95	Batch preparation of electrospun polycaprolactone/chitosan/aloe vera blended nanofiber membranes for novel wound dressing.
32470578	5	58	with	NFMs	807:810	arg1	ratio					836:840	the optimal weight ratio	817:840	the optimal weight ratio	817:840	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	8	59	theme	NFMs	1360:1363	arg1	yield					1341:1345	its yield	1337:1345	its yield of PCL/CS/AV NFMs	1337:1363	The results illustrated SFSE could prepare high quality PCL/CS/AV NFMs in batches, and its yield of PCL/CS/AV NFMs was 10 times more than the single-needle ES, and the fabricated NFMs showed excellent antibacterial performance and biocompatibility, which made them suitable for wound dressings.
32470578	4	60	with	NFMs	593:596	arg1	ratios					618:623	varying weight ratios	603:623	varying weight ratios of PCL:CS:AV	603:636	And the morphologies of PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV were studied using SEM, and the optimal weight ratio of 5:3:2 was determined for better wound dressings.
32470578	2	61	theme	dressings	325:333	arg1	field					310:314	the field	306:314	the field of wound dressings	306:333	Chitosan, a kind of carbohydrate polymer with good biocompatibility, is widely used in the field of wound dressings.
32470578	3	62	theme	electrospinning	375:389	arg1	device					398:403	a slopeing free surface electrospinning (SFSE) device	351:403	a slopeing free surface electrospinning (SFSE) device	351:403	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	8	63	theme	single-needle	1392:1404	arg1	ES					1406:1407	the single-needle ES	1388:1407	the single-needle ES	1388:1407	The results illustrated SFSE could prepare high quality PCL/CS/AV NFMs in batches, and its yield of PCL/CS/AV NFMs was 10 times more than the single-needle ES, and the fabricated NFMs showed excellent antibacterial performance and biocompatibility, which made them suitable for wound dressings.
32470578	5	64	theme	NFMs	960:963	arg1	performance					920:930	the antibacterial performance	902:930	the antibacterial performance	902:930	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	5	64	theme	NFMs	960:963	arg1	biocompatibility					940:955	the biocompatibility	936:955	the biocompatibility of NFMs	936:963	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	1	65	theme	more	135:138	arg1	attention					149:157	more and more attention	135:157	more and more attention	135:157	At present, more and more attention has been paid to the development of active wound dressings.
32470578	8	66	theme	PCL/CS/AV	1306:1314	arg1	NFMs					1316:1319	high quality PCL/CS/AV NFMs	1293:1319	high quality PCL/CS/AV NFMs in batches	1293:1330	The results illustrated SFSE could prepare high quality PCL/CS/AV NFMs in batches, and its yield of PCL/CS/AV NFMs was 10 times more than the single-needle ES, and the fabricated NFMs showed excellent antibacterial performance and biocompatibility, which made them suitable for wound dressings.
32470578	4	67	theme	optimal	670:676	arg1	ratio					685:689	the optimal weight ratio	666:689	the optimal weight ratio of 5:3:2	666:698	And the morphologies of PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV were studied using SEM, and the optimal weight ratio of 5:3:2 was determined for better wound dressings.
32470578	2	68	used	used	298:301	arg2	Chitosan					219:226	Chitosan	219:226	Chitosan	219:226	Chitosan, a kind of carbohydrate polymer with good biocompatibility, is widely used in the field of wound dressings.
32470578	2	68	used	used	298:301	arg2	kind					231:234	a kind	229:234	a kind of carbohydrate polymer with good biocompatibility	229:285	Chitosan, a kind of carbohydrate polymer with good biocompatibility, is widely used in the field of wound dressings.
32470578	4	69	theme	NFMs	593:596	arg1	morphologies					567:578	And the morphologies	559:578	morphologies	567:578	And the morphologies of PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV were studied using SEM, and the optimal weight ratio of 5:3:2 was determined for better wound dressings.
32470578	6	70	theme	Maxwell	1092:1098	arg1	3D					1100:1101	Maxwell 3D	1092:1101	Maxwell 3D	1092:1101	In addition, the preparation mechanism of SFSE was researched by simulating the electric field distribution using Maxwell 3D due to the important role of the electric field in the SFSE process.
32470578	2	71	theme	polymer	252:258	arg1	Chitosan					219:226	Chitosan	219:226	Chitosan	219:226	Chitosan, a kind of carbohydrate polymer with good biocompatibility, is widely used in the field of wound dressings.
32470578	2	71	theme	polymer	252:258	arg1	kind					231:234	a kind	229:234	a kind of carbohydrate polymer with good biocompatibility	229:285	Chitosan, a kind of carbohydrate polymer with good biocompatibility, is widely used in the field of wound dressings.
32470578	1	72	theme	more	144:147	arg1	attention					149:157	more and more attention	135:157	more and more attention	135:157	At present, more and more attention has been paid to the development of active wound dressings.
32470578	4	73	theme	PCL/CS/AV	583:591	arg1	NFMs					593:596	PCL/CS/AV NFMs	583:596	PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV	583:636	And the morphologies of PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV were studied using SEM, and the optimal weight ratio of 5:3:2 was determined for better wound dressings.
32470578	5	74	theme	optimal	821:827	arg1	ratio					836:840	the optimal weight ratio	817:840	the optimal weight ratio	817:840	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	2	75	theme	carbohydrate	239:250	arg1	polymer					252:258	carbohydrate polymer	239:258	carbohydrate polymer	239:258	Chitosan, a kind of carbohydrate polymer with good biocompatibility, is widely used in the field of wound dressings.
32470578	3	76	theme	large	430:434	arg1	quantities					436:445	large quantities	430:445	large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs)	430:523	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	3	77	theme	nanofiber	498:506	arg1	NFMs					519:522	NFMs	519:522	NFMs	519:522	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	3	77	theme	nanofiber	498:506	arg1	membranes					508:516	polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes	450:516	polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs)	450:523	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	5	78	from	effects	869:875	arg1	performance					920:930	the antibacterial performance	902:930	the antibacterial performance	902:930	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	5	78	from	effects	869:875	arg1	biocompatibility					940:955	the biocompatibility	936:955	the biocompatibility of NFMs	936:963	Then the structure, wetting property and yield of the PCL/CS/AV NFMs with the optimal weight ratio were investigated, and the effects of the addition of AV on the antibacterial performance and the biocompatibility of NFMs was studied.
32470578	4	79	theme	varying	603:609	arg1	ratios					618:623	varying weight ratios	603:623	varying weight ratios of PCL:CS:AV	603:636	And the morphologies of PCL/CS/AV NFMs with varying weight ratios of PCL:CS:AV were studied using SEM, and the optimal weight ratio of 5:3:2 was determined for better wound dressings.
32470578	3	80	theme	surface	367:373	arg1	device					398:403	a slopeing free surface electrospinning (SFSE) device	351:403	a slopeing free surface electrospinning (SFSE) device	351:403	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
32470578	6	81	theme	electric	1058:1065	arg1	distribution					1073:1084	the electric field distribution	1054:1084	the electric field distribution using Maxwell 3D	1054:1101	In addition, the preparation mechanism of SFSE was researched by simulating the electric field distribution using Maxwell 3D due to the important role of the electric field in the SFSE process.
32470578	3	82	theme	membranes	508:516	arg1	quantities					436:445	large quantities	430:445	large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs)	430:523	In this study, a slopeing free surface electrospinning (SFSE) device was presented to prepare large quantities of polycaprolactone/chitosan/aloe vera (PCL/CS/AV) nanofiber membranes (NFMs) for antibacterial wound dressing.
34228194	2	0	used	used	253:256	arg2	analysis					240:247	GT bi-plot analysis	229:247	GT bi-plot analysis	229:247	GT bi-plot analysis was used for assessment of biochemical analysis results.
34228194	10	1	theme	parent	1587:1592	arg1	materials					1594:1602	parent materials	1587:1602	parent materials in further breeding studies	1587:1630	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	10	1	theme	parent	1587:1592	arg1	lines					1504:1508	Those lines	1498:1508	Those lines	1498:1508	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	7	2	theme	protein	819:825	arg1	content					827:833	digestible protein content	808:833	digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%)	808:983	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	1	3	from	variation	121:129	arg1	protein					134:140	protein	134:140	protein	134:140	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	1	3	from	variation	121:129	arg1	attributes					196:205	phytic acid-like biochemical attributes	167:205	phytic acid-like biochemical attributes of sorghum genotypes	167:226	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	1	3	from	variation	121:129	arg1	tannin					156:161	tannin	156:161	tannin	156:161	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	1	3	from	variation	121:129	arg1	starch					148:153	starch	148:153	starch	148:153	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	1	3	from	variation	121:129	arg1	oil					143:145	oil	143:145	oil	143:145	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	10	4	theme	breeding	1615:1622	arg1	studies					1624:1630	further breeding studies	1607:1630	further breeding studies	1607:1630	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	10	5	theme	various	1652:1658	arg1	purposes					1660:1667	various purposes	1652:1667	various purposes in long run	1652:1679	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	2	6	theme	analysis	288:295	arg1	results					297:303	biochemical analysis results	276:303	biochemical analysis results	276:303	GT bi-plot analysis was used for assessment of biochemical analysis results.
34228194	1	7	theme	phytic	167:172	arg1	attributes					196:205	phytic acid-like biochemical attributes	167:205	phytic acid-like biochemical attributes of sorghum genotypes	167:226	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	8	8	theme	phytic	1224:1229	arg1	contents					1236:1243	phytic acid contents	1224:1243	phytic acid contents	1224:1243	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	6	9	theme	biochemical	538:548	arg1	composition					550:560	biochemical composition	538:560	biochemical composition of new 154 sorghum lines, selected from Turkish sorghum landraces through morphological, biochemical and molecular studies,	538:684	In this study, biochemical composition of new 154 sorghum lines, selected from Turkish sorghum landraces through morphological, biochemical and molecular studies, was determined.
34228194	7	10	theme	starch	910:915	arg1	lines					841:845	94 lines	838:845	94 lines (> 56.25%)	838:856	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	10	theme	starch	910:915	arg1	ratio					917:921	resistant starch ratio	900:921	resistant starch ratio of 32 lines (> 3.93%)	900:943	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	1	11	theme	biochemical	184:194	arg1	attributes					196:205	phytic acid-like biochemical attributes	167:205	phytic acid-like biochemical attributes of sorghum genotypes	167:226	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	4	12	theme	basic	395:399	arg1	source					401:406	the basic source	391:406	the basic source of nutrient in majority of developing countries	391:454	Thus, it has become the basic source of nutrient in majority of developing countries.
34228194	9	13	theme	sorghum	1430:1436	arg1	lines					1438:1442	several sorghum lines	1422:1442	several sorghum lines superior than the standard cultivars	1422:1479	With this study, several sorghum lines superior than the standard cultivars were identified.
34228194	8	14	theme	condense	1249:1256	arg1	contents					1266:1273	condense tannins contents	1249:1273	condense tannins contents	1249:1273	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	0	15	dep	bicolor	64:70	arg1	L.					72:73	sorghum (Sorghum bicolor L.)	47:74	sorghum (Sorghum bicolor L.)	47:74	Biochemical composition of selected lines from sorghum (Sorghum bicolor L.) landraces.
34228194	10	16	theme	direct	1526:1531	arg1	registration					1542:1553	direct cultivar registration	1526:1553	direct cultivar registration	1526:1553	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	5	17	theme	supporting	478:487	arg1	It					457:458	It	457:458	It	457:458	It is also used as a supporting product against several diseases.
34228194	5	17	theme	supporting	478:487	arg1	product					489:495	a supporting product	476:495	a supporting product against several diseases	476:520	It is also used as a supporting product against several diseases.
34228194	9	18	theme	superior	1444:1451	arg1	lines					1438:1442	several sorghum lines	1422:1442	several sorghum lines superior than the standard cultivars	1422:1479	With this study, several sorghum lines superior than the standard cultivars were identified.
34228194	6	19	theme	Turkish	602:608	arg1	landraces					618:626	Turkish sorghum landraces	602:626	Turkish sorghum landraces	602:626	In this study, biochemical composition of new 154 sorghum lines, selected from Turkish sorghum landraces through morphological, biochemical and molecular studies, was determined.
34228194	7	20	theme	standard	1046:1053	arg1	cultivar					1055:1062	standard cultivar	1046:1062	standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values	1046:1196	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	3	21	theme	negative	336:343	arg1	conditions					359:368	negative environmental conditions	336:368	negative environmental conditions	336:368	Sorghum is quite resistant to negative environmental conditions.
34228194	2	22	theme	bi-plot	232:238	arg1	analysis					240:247	GT bi-plot analysis	229:247	GT bi-plot analysis	229:247	GT bi-plot analysis was used for assessment of biochemical analysis results.
34228194	6	23	theme	lines	581:585	arg1	composition					550:560	biochemical composition	538:560	biochemical composition of new 154 sorghum lines, selected from Turkish sorghum landraces through morphological, biochemical and molecular studies,	538:684	In this study, biochemical composition of new 154 sorghum lines, selected from Turkish sorghum landraces through morphological, biochemical and molecular studies, was determined.
34228194	4	24	theme	countries	446:454	arg1	majority					423:430	majority	423:430	majority of developing countries	423:454	Thus, it has become the basic source of nutrient in majority of developing countries.
34228194	10	25	from	purposes	1660:1667	arg1	run					1677:1679	long run	1672:1679	long run	1672:1679	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	7	26	theme	crude	859:863	arg1	lines					841:845	94 lines	838:845	94 lines (> 56.25%)	838:856	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	26	theme	crude	859:863	arg1	content					869:875	crude oil content	859:875	crude oil content of 75 lines (> 3.87%)	859:897	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	10	27	used	used	1579:1582	arg2	lines					1504:1508	Those lines	1498:1508	Those lines	1498:1508	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	10	27	used	used	1579:1582	arg2	materials					1594:1602	parent materials	1587:1602	parent materials in further breeding studies	1587:1630	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	6	28	theme	molecular	667:675	arg1	studies					677:683	morphological, biochemical and molecular studies	636:683	morphological, biochemical and molecular studies	636:683	In this study, biochemical composition of new 154 sorghum lines, selected from Turkish sorghum landraces through morphological, biochemical and molecular studies, was determined.
34228194	0	29	theme	Biochemical	0:10	arg1	composition					12:22	Biochemical composition	0:22	Biochemical composition of selected lines from sorghum (Sorghum bicolor L.)	0:74	Biochemical composition of selected lines from sorghum (Sorghum bicolor L.) landraces.
34228194	6	30	theme	biochemical	651:661	arg1	studies					677:683	morphological, biochemical and molecular studies	636:683	morphological, biochemical and molecular studies	636:683	In this study, biochemical composition of new 154 sorghum lines, selected from Turkish sorghum landraces through morphological, biochemical and molecular studies, was determined.
34228194	7	31	theme	crude	763:767	arg1	content					777:783	crude protein content	763:783	crude protein content of 80 lines (> 9.65%)	763:805	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	32	dep	revealed	719:726	arg1	based					728:732	based	728:732	revealed based on average of two years that crude protein content of 80 lines (> 9.65%)	719:805	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	10	33	theme	short	1558:1562	arg1	run					1564:1566	short run	1558:1566	short run	1558:1566	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	6	34	theme	morphological	636:648	arg1	studies					677:683	morphological, biochemical and molecular studies	636:683	morphological, biochemical and molecular studies	636:683	In this study, biochemical composition of new 154 sorghum lines, selected from Turkish sorghum landraces through morphological, biochemical and molecular studies, was determined.
34228194	0	35	theme	lines	36:40	arg1	composition					12:22	Biochemical composition	0:22	Biochemical composition of selected lines from sorghum (Sorghum bicolor L.)	0:74	Biochemical composition of selected lines from sorghum (Sorghum bicolor L.) landraces.
34228194	7	36	theme	years	752:756	arg1	average					737:743	average	737:743	average of two years that crude protein content of 80 lines (> 9.65%)	737:805	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	0	37	theme	Sorghum	56:62	arg1	bicolor					64:70	sorghum (Sorghum bicolor L.)	47:74	sorghum (Sorghum bicolor L.)	47:74	Biochemical composition of selected lines from sorghum (Sorghum bicolor L.) landraces.
34228194	0	38	theme	sorghum	47:53	arg1	bicolor					64:70	sorghum (Sorghum bicolor L.)	47:74	sorghum (Sorghum bicolor L.)	47:74	Biochemical composition of selected lines from sorghum (Sorghum bicolor L.) landraces.
34228194	8	39	dep	0.02	1318:1321	arg1	12850/1					1327:1333	12850/1	1327:1333	12850/1	1327:1333	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	8	39	dep	0.02	1318:1321	arg1	%					1385:1385	-5.38%	1380:1385	-5.38% (PI 255738 02/3)	1380:1402	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	8	39	dep	0.02	1318:1321	arg1	02/3					1398:1401	PI 255738 02/3	1388:1401	PI 255738 02/3	1388:1401	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	8	39	dep	0.02	1318:1321	arg1	%					1340:1340	-6.49%	1335:1340	0.02 (IS 12850/1)-6.49% (PI 177161 03/2)	1318:1357	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	1	40	theme	sorghum	210:216	arg1	genotypes					218:226	sorghum genotypes	210:226	sorghum genotypes	210:226	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	7	41	theme	greatest	1073:1080	arg1	values					1082:1087	the greatest values	1069:1087	the greatest values	1069:1087	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	42	with	cultivar	1055:1062	arg1	values					1082:1087	the greatest values	1069:1087	the greatest values	1069:1087	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	42	with	cultivar	1055:1062	arg1	contents					1105:1112	amylopectin contents	1093:1112	amylopectin contents	1093:1112	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	8	43	theme	PI	1388:1389	arg1	%					1385:1385	-5.38%	1380:1385	-5.38% (PI 255738 02/3)	1380:1402	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	8	43	theme	PI	1388:1389	arg1	02/3					1398:1401	PI 255738 02/3	1388:1401	PI 255738 02/3	1388:1401	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	7	44	theme	Present	702:708	arg1	findings					710:717	Present findings	702:717	Present findings	702:717	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	45	theme	lines	968:972	arg1	content					997:1003	amylose content	989:1003	amylose content	989:1003	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	45	theme	lines	968:972	arg1	content					827:833	digestible protein content	808:833	digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%)	808:983	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	46	theme	digestible	808:817	arg1	content					827:833	digestible protein content	808:833	digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%)	808:983	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	6	47	theme	sorghum	573:579	arg1	lines					581:585	new 154 sorghum lines	565:585	new 154 sorghum lines	565:585	In this study, biochemical composition of new 154 sorghum lines, selected from Turkish sorghum landraces through morphological, biochemical and molecular studies, was determined.
34228194	10	48	theme	further	1607:1613	arg1	studies					1624:1630	further breeding studies	1607:1630	further breeding studies	1607:1630	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	7	49	theme	starch	946:951	arg1	content					953:959	starch content	946:959	starch content	946:959	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	49	theme	starch	946:951	arg1	lines					841:845	94 lines	838:845	94 lines (> 56.25%)	838:856	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	2	50	theme	results	297:303	arg1	assessment					262:271	assessment	262:271	assessment of biochemical analysis results	262:303	GT bi-plot analysis was used for assessment of biochemical analysis results.
34228194	5	51	used	used	468:471	arg2	product					489:495	a supporting product	476:495	a supporting product against several diseases	476:520	It is also used as a supporting product against several diseases.
34228194	5	51	used	used	468:471	arg2	It					457:458	It	457:458	It	457:458	It is also used as a supporting product against several diseases.
34228194	6	52	theme	new	565:567	arg1	lines					581:585	new 154 sorghum lines	565:585	new 154 sorghum lines	565:585	In this study, biochemical composition of new 154 sorghum lines, selected from Turkish sorghum landraces through morphological, biochemical and molecular studies, was determined.
34228194	2	53	theme	biochemical	276:286	arg1	results					297:303	biochemical analysis results	276:303	biochemical analysis results	276:303	GT bi-plot analysis was used for assessment of biochemical analysis results.
34228194	10	54	from	materials	1594:1602	arg1	studies					1624:1630	further breeding studies	1607:1630	further breeding studies	1607:1630	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	8	55	theme	acid	1231:1234	arg1	contents					1236:1243	phytic acid contents	1224:1243	phytic acid contents	1224:1243	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	7	56	theme	lines	791:795	arg1	content					777:783	crude protein content	763:783	crude protein content of 80 lines (> 9.65%)	763:805	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	1	57	theme	acid-like	174:182	arg1	attributes					196:205	phytic acid-like biochemical attributes	167:205	phytic acid-like biochemical attributes of sorghum genotypes	167:226	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	0	58	from	bicolor	64:70	arg1	composition					12:22	Biochemical composition	0:22	Biochemical composition of selected lines from sorghum (Sorghum bicolor L.)	0:74	Biochemical composition of selected lines from sorghum (Sorghum bicolor L.) landraces.
34228194	7	59	theme	lowest	1184:1189	arg1	values					1191:1196	the lowest values	1180:1196	the lowest values	1180:1196	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	10	60	theme	long	1672:1675	arg1	run					1677:1679	long run	1672:1679	long run	1672:1679	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	7	61	theme	lines	929:933	arg1	lines					841:845	94 lines	838:845	94 lines (> 56.25%)	838:856	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	61	theme	lines	929:933	arg1	ratio					917:921	resistant starch ratio	900:921	resistant starch ratio of 32 lines (> 3.93%)	900:943	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	10	62	used	used	1517:1520	arg2	lines					1504:1508	Those lines	1498:1508	Those lines	1498:1508	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	10	62	used	used	1517:1520	arg2	materials					1594:1602	parent materials	1587:1602	parent materials in further breeding studies	1587:1630	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	9	63	theme	several	1422:1428	arg1	lines					1438:1442	several sorghum lines	1422:1442	several sorghum lines superior than the standard cultivars	1422:1479	With this study, several sorghum lines superior than the standard cultivars were identified.
34228194	8	64	theme	tannins	1258:1264	arg1	contents					1266:1273	condense tannins contents	1249:1273	condense tannins contents	1249:1273	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	4	65	from	source	401:406	arg1	majority					423:430	majority	423:430	majority of developing countries	423:454	Thus, it has become the basic source of nutrient in majority of developing countries.
34228194	10	66	theme	cultivar	1533:1540	arg1	registration					1542:1553	direct cultivar registration	1526:1553	direct cultivar registration	1526:1553	Those lines can be used for direct cultivar registration in short run and can be used as parent materials in further breeding studies to be conducted for various purposes in long run.
34228194	7	67	theme	resistant	900:908	arg1	lines					841:845	94 lines	838:845	94 lines (> 56.25%)	838:856	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	67	theme	resistant	900:908	arg1	ratio					917:921	resistant starch ratio	900:921	resistant starch ratio of 32 lines (> 3.93%)	900:943	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	1	68	theme	great	115:119	arg1	variation					121:129	a great variation	113:129	a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes	113:226	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	4	69	theme	nutrient	411:418	arg1	source					401:406	the basic source	391:406	the basic source of nutrient in majority of developing countries	391:454	Thus, it has become the basic source of nutrient in majority of developing countries.
34228194	7	70	theme	standard	1157:1164	arg1	cultivar					1166:1173	the standard cultivar	1153:1173	the standard cultivar with the lowest values	1153:1196	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	6	71	theme	sorghum	610:616	arg1	landraces					618:626	Turkish sorghum landraces	602:626	Turkish sorghum landraces	602:626	In this study, biochemical composition of new 154 sorghum lines, selected from Turkish sorghum landraces through morphological, biochemical and molecular studies, was determined.
34228194	2	72	theme	GT	229:230	arg1	analysis					240:247	GT bi-plot analysis	229:247	GT bi-plot analysis	229:247	GT bi-plot analysis was used for assessment of biochemical analysis results.
34228194	8	73	theme	lines	1282:1286	arg1	contents					1236:1243	phytic acid contents	1224:1243	phytic acid contents	1224:1243	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	8	73	theme	lines	1282:1286	arg1	contents					1266:1273	condense tannins contents	1249:1273	condense tannins contents	1249:1273	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	5	74	theme	several	505:511	arg1	diseases					513:520	several diseases	505:520	several diseases	505:520	It is also used as a supporting product against several diseases.
34228194	9	75	theme	standard	1462:1469	arg1	cultivars					1471:1479	the standard cultivars	1458:1479	the standard cultivars	1458:1479	With this study, several sorghum lines superior than the standard cultivars were identified.
34228194	7	76	with	cultivar	1166:1173	arg1	values					1191:1196	the lowest values	1180:1196	the lowest values	1180:1196	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	8	77	dep	0.09	1363:1366	arg1	12819/1					1372:1378	12819/1	1372:1378	12819/1	1372:1378	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	7	78	theme	lines	883:887	arg1	lines					841:845	94 lines	838:845	94 lines (> 56.25%)	838:856	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	78	theme	lines	883:887	arg1	content					869:875	crude oil content	859:875	crude oil content of 75 lines (> 3.87%)	859:897	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	3	79	theme	environmental	345:357	arg1	conditions					359:368	negative environmental conditions	336:368	negative environmental conditions	336:368	Sorghum is quite resistant to negative environmental conditions.
34228194	7	80	theme	lines	1011:1015	arg1	content					997:1003	amylose content	989:1003	amylose content	989:1003	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	80	theme	lines	1011:1015	arg1	content					827:833	digestible protein content	808:833	digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%)	808:983	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	81	theme	oil	865:867	arg1	lines					841:845	94 lines	838:845	94 lines (> 56.25%)	838:856	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	81	theme	oil	865:867	arg1	content					869:875	crude oil content	859:875	crude oil content of 75 lines (> 3.87%)	859:897	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	0	82	theme	selected	27:34	arg1	lines					36:40	selected lines	27:40	selected lines	27:40	Biochemical composition of selected lines from sorghum (Sorghum bicolor L.) landraces.
34228194	1	83	theme	Present	87:93	arg1	findings					95:102	Present findings	87:102	Present findings	87:102	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	7	84	theme	lines	1120:1124	arg1	values					1082:1087	the greatest values	1069:1087	the greatest values	1069:1087	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	84	theme	lines	1120:1124	arg1	contents					1105:1112	amylopectin contents	1093:1112	amylopectin contents	1093:1112	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	85	theme	amylose	989:995	arg1	content					997:1003	amylose content	989:1003	amylose content	989:1003	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	86	theme	protein	769:775	arg1	content					777:783	crude protein content	763:783	crude protein content of 80 lines (> 9.65%)	763:805	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	87	theme	amylopectin	1093:1103	arg1	contents					1105:1112	amylopectin contents	1093:1112	amylopectin contents	1093:1112	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	8	88	theme	PI	1343:1344	arg1	03/2					1353:1356	PI 177161 03/2	1343:1356	PI 177161 03/2	1343:1356	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	8	88	theme	PI	1343:1344	arg1	0.02					1318:1321	0.02	1318:1321	0.02	1318:1321	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	4	89	theme	developing	435:444	arg1	countries					446:454	developing countries	435:454	developing countries	435:454	Thus, it has become the basic source of nutrient in majority of developing countries.
34228194	7	90	theme	lines	841:845	arg1	content					997:1003	amylose content	989:1003	amylose content	989:1003	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	7	90	theme	lines	841:845	arg1	content					827:833	digestible protein content	808:833	digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%)	808:983	Present findings revealed based on average of two years that crude protein content of 80 lines (> 9.65%), digestible protein content of 94 lines (> 56.25%), crude oil content of 75 lines (> 3.87%), resistant starch ratio of 32 lines (> 3.93%), starch content of two lines (> 77.07%) and amylose content of 10 lines (> %25.26) were greater than standard cultivar with the greatest values and amylopectin contents of 74 lines (< 47.75%) were lower than the standard cultivar with the lowest values.
34228194	8	91	theme	years	1217:1221	arg1	average					1206:1212	the average	1202:1212	the average of years	1202:1221	As the average of years, phytic acid contents and condense tannins contents of the lines, respectively, varied between 0.02 (IS 12850/1)-6.49% (PI 177161 03/2) and 0.09 (IS 12819/1)-5.38% (PI 255738 02/3).
34228194	1	92	theme	genotypes	218:226	arg1	protein					134:140	protein	134:140	protein	134:140	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	1	92	theme	genotypes	218:226	arg1	attributes					196:205	phytic acid-like biochemical attributes	167:205	phytic acid-like biochemical attributes of sorghum genotypes	167:226	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	1	92	theme	genotypes	218:226	arg1	tannin					156:161	tannin	156:161	tannin	156:161	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	1	92	theme	genotypes	218:226	arg1	starch					148:153	starch	148:153	starch	148:153	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
34228194	1	92	theme	genotypes	218:226	arg1	oil					143:145	oil	143:145	oil	143:145	Present findings revealed a great variation in protein, oil, starch, tannin and phytic acid-like biochemical attributes of sorghum genotypes.
32388628	9	0	theme	EP	1216:1217	arg1	range					1233:1237	the 0.1-0.8 μM EP concentration range	1201:1237	the 0.1-0.8 μM EP concentration range	1201:1237	Response is linear in the 0.1-0.8 μM EP concentration range, at 0.03 V (vs. pseudo-Ag/AgCl), and the detection limit is 25 nM for the MNP-SPE.
32388628	9	0	theme	EP	1216:1217	arg1	at 0.03 V					1240:1248	at 0.03 V	1240:1248	at 0.03 V (vs. pseudo-Ag/AgCl)	1240:1269	Response is linear in the 0.1-0.8 μM EP concentration range, at 0.03 V (vs. pseudo-Ag/AgCl), and the detection limit is 25 nM for the MNP-SPE.
32388628	8	1	dep	MNP-SPE	1076:1082	arg1	the					1072:1074	the	1072:1074	the	1072:1074	The performances of the MNP-SPE and CHMNP-SPE were studied by DPV after optimization of equilibration time and DPV parameters.
32388628	11	2	theme	cerebrospinal	1517:1529	arg1	fluids					1541:1546	cerebrospinal synthetic fluids	1517:1546	cerebrospinal synthetic fluids	1517:1546	The devices were used for the quantification of EP in synthetic urine and in cerebrospinal synthetic fluids.
32388628	16	3	theme	voltammetric	2186:2197	arg1	determination					2199:2211	the voltammetric determination	2182:2211	the voltammetric determination of epinephrine (EP)	2182:2231	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	6	4	theme	better	842:847	arg1	responses					865:873	better electrochemical responses	842:873	better electrochemical responses	842:873	The CHMNP-SPE is found to have better electrochemical responses in comparison to the MNP-SPE.
32388628	9	5	from	linear	1191:1196	arg1	range					1233:1237	the 0.1-0.8 μM EP concentration range	1201:1237	the 0.1-0.8 μM EP concentration range	1201:1237	Response is linear in the 0.1-0.8 μM EP concentration range, at 0.03 V (vs. pseudo-Ag/AgCl), and the detection limit is 25 nM for the MNP-SPE.
32388628	9	5	from	linear	1191:1196	arg1	at 0.03 V					1240:1248	at 0.03 V	1240:1248	at 0.03 V (vs. pseudo-Ag/AgCl)	1240:1269	Response is linear in the 0.1-0.8 μM EP concentration range, at 0.03 V (vs. pseudo-Ag/AgCl), and the detection limit is 25 nM for the MNP-SPE.
32388628	16	6	theme	magnetite	2094:2102	arg1	MNPs					2119:2122	MNPs	2119:2122	MNPs	2119:2122	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	16	6	theme	magnetite	2094:2102	arg1	nanoparticles					2104:2116	magnetite nanoparticles	2094:2116	magnetite nanoparticles (MNPs)	2094:2123	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	12	7	theme	%	1601:1601	arg1	range					1603:1607	the 95.6-102.2% range	1587:1607	the 95.6-102.2% range for the CHMNP-SPE	1587:1625	Recoveries from spiked samples are in the 95.6-102.2% range for the CHMNP-SPE and in the 98.3-109% range for MNP-SPE.
32388628	14	8	theme	MNP-SPE	1848:1854	arg1	current					1880:1886	its EP peak current	1868:1886	its EP peak current	1868:1886	The EP peak currents were found to decrease by only 4% for the CHMNP-SPE, while the MNP-SPE lost 23% of its EP peak current.
32388628	14	8	theme	MNP-SPE	1848:1854	arg1	%					1863:1863	the MNP-SPE lost 23%	1844:1863	the MNP-SPE lost 23% of its EP peak current	1844:1886	The EP peak currents were found to decrease by only 4% for the CHMNP-SPE, while the MNP-SPE lost 23% of its EP peak current.
32388628	17	9	theme	CHMNP-SPE	2255:2263	arg1	response					2243:2250	Improved response	2234:2250	Improved response of CHMNP-SPE (black voltammogram) in comparison to MNP-SPE (red voltammogram)	2234:2328	Improved response of CHMNP-SPE (black voltammogram) in comparison to MNP-SPE (red voltammogram) was attributed to the protection of MNP from oxidation.
32388628	1	10	theme	composites	282:291	arg1	use					253:255	the use	249:255	the use of graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE)	249:394	Disposable screen-printed electrodes based on the use of graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE) are described.
32388628	17	11	theme	black	2266:2270	arg1	CHMNP-SPE					2255:2263	CHMNP-SPE	2255:2263	CHMNP-SPE (black voltammogram)	2255:2284	Improved response of CHMNP-SPE (black voltammogram) in comparison to MNP-SPE (red voltammogram) was attributed to the protection of MNP from oxidation.
32388628	17	11	theme	black	2266:2270	arg1	voltammogram					2272:2283	black voltammogram	2266:2283	black voltammogram	2266:2283	Improved response of CHMNP-SPE (black voltammogram) in comparison to MNP-SPE (red voltammogram) was attributed to the protection of MNP from oxidation.
32388628	16	12	theme	chitosan-coated	2129:2143	arg1	CHMNPs					2170:2175	CHMNPs	2170:2175	CHMNPs	2170:2175	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	16	12	theme	chitosan-coated	2129:2143	arg1	nanoparticles					2155:2167	chitosan-coated magnetite nanoparticles	2129:2167	chitosan-coated magnetite nanoparticles (CHMNPs)	2129:2176	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	9	13	theme	detection	1280:1288	arg1	limit					1290:1294	the detection limit	1276:1294	the detection limit	1276:1294	Response is linear in the 0.1-0.8 μM EP concentration range, at 0.03 V (vs. pseudo-Ag/AgCl), and the detection limit is 25 nM for the MNP-SPE.
32388628	9	13	theme	detection	1280:1288	arg1	25 nM					1299:1303	25 nM	1299:1303	25 nM	1299:1303	Response is linear in the 0.1-0.8 μM EP concentration range, at 0.03 V (vs. pseudo-Ag/AgCl), and the detection limit is 25 nM for the MNP-SPE.
32388628	11	14	used	used	1457:1460	arg2	The devices					1440:1450	The devices	1440:1450	The devices	1440:1450	The devices were used for the quantification of EP in synthetic urine and in cerebrospinal synthetic fluids.
32388628	7	15	theme	applied	1026:1032	arg1	fields					1044:1049	different applied potential fields	1016:1049	different applied potential fields	1016:1049	This is assumed to be due to the chitosan coating which also protects the MNPs from oxidation under air and at different applied potential fields.
32388628	0	16	dep	study	196:200	arg1	electrodes					26:35	Screen-printed disposable electrodes	0:35	Screen-printed disposable electrodes using graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing	0:179	Screen-printed disposable electrodes using graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing: a comparative study.
32388628	9	17	from	range	1233:1237	arg1	linear					1191:1196	linear	1191:1196	linear	1191:1196	Response is linear in the 0.1-0.8 μM EP concentration range, at 0.03 V (vs. pseudo-Ag/AgCl), and the detection limit is 25 nM for the MNP-SPE.
32388628	0	18	theme	magnetite	90:98	arg1	nanoparticles					130:142	magnetite and chitosan-coated magnetite nanoparticles	90:142	magnetite and chitosan-coated magnetite nanoparticles	90:142	Screen-printed disposable electrodes using graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing: a comparative study.
32388628	12	19	theme	spiked	1565:1570	arg1	samples					1572:1578	spiked samples	1565:1578	spiked samples	1565:1578	Recoveries from spiked samples are in the 95.6-102.2% range for the CHMNP-SPE and in the 98.3-109% range for MNP-SPE.
32388628	17	20	from	oxidation	2375:2383	arg1	protection					2352:2361	the protection	2348:2361	the protection of MNP from oxidation	2348:2383	Improved response of CHMNP-SPE (black voltammogram) in comparison to MNP-SPE (red voltammogram) was attributed to the protection of MNP from oxidation.
32388628	0	21	theme	chitosan-coated	104:118	arg1	nanoparticles					130:142	magnetite and chitosan-coated magnetite nanoparticles	90:142	magnetite and chitosan-coated magnetite nanoparticles	90:142	Screen-printed disposable electrodes using graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing: a comparative study.
32388628	1	22	theme	screen-printed	214:227	arg1	electrodes					229:238	Disposable screen-printed electrodes	203:238	Disposable screen-printed electrodes based on the use of graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE)	203:394	Disposable screen-printed electrodes based on the use of graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE) are described.
32388628	13	23	theme	respective sensors	1688:1705	arg1	stability					1671:1679	The stability	1667:1679	The stability of the respective sensors	1667:1705	The stability of the respective sensors was investigated and compared over a period of 5 months.
32388628	8	24	theme	MNP-SPE	1076:1082	arg1	performances					1056:1067	The performances	1052:1067	The performances of the MNP-SPE and CHMNP-SPE	1052:1096	The performances of the MNP-SPE and CHMNP-SPE were studied by DPV after optimization of equilibration time and DPV parameters.
32388628	12	25	theme	%	1646:1646	arg1	range					1648:1652	the 98.3-109% range	1634:1652	the 98.3-109% range for MNP-SPE	1634:1664	Recoveries from spiked samples are in the 95.6-102.2% range for the CHMNP-SPE and in the 98.3-109% range for MNP-SPE.
32388628	6	26	contain	have	837:840	arg2	responses					865:873	better electrochemical responses	842:873	better electrochemical responses	842:873	The CHMNP-SPE is found to have better electrochemical responses in comparison to the MNP-SPE.
32388628	6	26	contain	have	837:840	arg1	CHMNP-SPE					815:823	The CHMNP-SPE	811:823	The CHMNP-SPE	811:823	The CHMNP-SPE is found to have better electrochemical responses in comparison to the MNP-SPE.
32388628	16	27	theme	composite	2069:2077	arg1	electrode					2079:2087	a graphite-polyurethane screen-printed composite electrode	2030:2087	a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs)	2030:2176	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	0	28	theme	voltammetric	148:159	arg1	sensing					173:179	voltammetric epinephrine sensing	148:179	voltammetric epinephrine sensing	148:179	Screen-printed disposable electrodes using graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing: a comparative study.
32388628	8	29	theme	CHMNP-SPE	1088:1096	arg1	performances					1056:1067	The performances	1052:1067	The performances of the MNP-SPE and CHMNP-SPE	1052:1096	The performances of the MNP-SPE and CHMNP-SPE were studied by DPV after optimization of equilibration time and DPV parameters.
32388628	0	30	theme	Screen-printed	0:13	arg1	electrodes					26:35	Screen-printed disposable electrodes	0:35	Screen-printed disposable electrodes using graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing	0:179	Screen-printed disposable electrodes using graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing: a comparative study.
32388628	1	31	theme	chitosan-coated	344:358	arg1	nanoparticles					370:382	chitosan-coated magnetite nanoparticles	344:382	chitosan-coated magnetite nanoparticles (CHMNP-SPE)	344:394	Disposable screen-printed electrodes based on the use of graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE) are described.
32388628	1	31	theme	chitosan-coated	344:358	arg1	CHMNP-SPE					385:393	CHMNP-SPE	385:393	CHMNP-SPE	385:393	Disposable screen-printed electrodes based on the use of graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE) are described.
32388628	4	32	theme	percentage	601:610	arg1	optimization					577:588	optimization	577:588	optimization of the MNP percentage in MNP-SPE	577:621	After optimization of the MNP percentage in MNP-SPE, the materials were electrochemically characterized by cyclic voltammetry, EIS, and chronocoulometry.
32388628	15	33	theme	sensitive	1950:1958	arg1	CHMNP-SPE					1906:1914	the CHMNP-SPE	1902:1914	the CHMNP-SPE	1902:1914	Accordingly, the CHMNP-SPE was chosen as the most stable and sensitive sensor for EP.
32388628	15	33	theme	sensitive	1950:1958	arg1	sensor					1960:1965	the most stable and sensitive sensor	1930:1965	the most stable and sensitive sensor for EP	1930:1972	Accordingly, the CHMNP-SPE was chosen as the most stable and sensitive sensor for EP.
32388628	11	34	theme	synthetic	1531:1539	arg1	fluids					1541:1546	cerebrospinal synthetic fluids	1517:1546	cerebrospinal synthetic fluids	1517:1546	The devices were used for the quantification of EP in synthetic urine and in cerebrospinal synthetic fluids.
32388628	7	35	from	oxidation	989:997	arg1	MNPs					979:982	the MNPs	975:982	the MNPs from oxidation	975:997	This is assumed to be due to the chitosan coating which also protects the MNPs from oxidation under air and at different applied potential fields.
32388628	15	36	theme	stable	1939:1944	arg1	CHMNP-SPE					1906:1914	the CHMNP-SPE	1902:1914	the CHMNP-SPE	1902:1914	Accordingly, the CHMNP-SPE was chosen as the most stable and sensitive sensor for EP.
32388628	15	36	theme	stable	1939:1944	arg1	sensor					1960:1965	the most stable and sensitive sensor	1930:1965	the most stable and sensitive sensor for EP	1930:1972	Accordingly, the CHMNP-SPE was chosen as the most stable and sensitive sensor for EP.
32388628	0	37	theme	graphite-polyurethane	43:63	arg1	composites					65:74	graphite-polyurethane composites	43:74	graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing	43:179	Screen-printed disposable electrodes using graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing: a comparative study.
32388628	16	38	theme	Schematic	1994:2002	arg1	figure					2004:2009	Graphical abstract Schematic figure	1975:2009	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).	1975:2232	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	4	39	from	optimization	577:588	arg1	MNP-SPE					615:621	MNP-SPE	615:621	MNP-SPE	615:621	After optimization of the MNP percentage in MNP-SPE, the materials were electrochemically characterized by cyclic voltammetry, EIS, and chronocoulometry.
32388628	14	40	theme	EP	1768:1769	arg1	currents					1776:1783	The EP peak currents	1764:1783	The EP peak currents	1764:1783	The EP peak currents were found to decrease by only 4% for the CHMNP-SPE, while the MNP-SPE lost 23% of its EP peak current.
32388628	8	41	theme	equilibration	1140:1152	arg1	time					1154:1157	equilibration time	1140:1157	equilibration time	1140:1157	The performances of the MNP-SPE and CHMNP-SPE were studied by DPV after optimization of equilibration time and DPV parameters.
32388628	10	42	theme	14 nM	1420:1424	arg1	LOD					1413:1415	a LOD	1411:1415	a LOD of 14 nM	1411:1424	The linear response for the CHMNP-SPE was 0.1-0.6 μM, at 0.0 V (vs. pseudo-Ag/AgCl), and a LOD of 14 nM was achieved.
32388628	1	43	theme	magnetite	307:315	arg1	MNP-SPE					332:338	MNP-SPE	332:338	MNP-SPE	332:338	Disposable screen-printed electrodes based on the use of graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE) are described.
32388628	1	43	theme	magnetite	307:315	arg1	nanoparticles					317:329	magnetite nanoparticles	307:329	magnetite nanoparticles (MNP-SPE)	307:339	Disposable screen-printed electrodes based on the use of graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE) are described.
32388628	8	44	theme	parameters	1167:1176	arg1	optimization					1124:1135	optimization	1124:1135	optimization of equilibration time and DPV parameters	1124:1176	The performances of the MNP-SPE and CHMNP-SPE were studied by DPV after optimization of equilibration time and DPV parameters.
32388628	14	45	theme	peak	1875:1878	arg1	current					1880:1886	its EP peak current	1868:1886	its EP peak current	1868:1886	The EP peak currents were found to decrease by only 4% for the CHMNP-SPE, while the MNP-SPE lost 23% of its EP peak current.
32388628	16	46	theme	Graphical	1975:1983	arg1	figure					2004:2009	Graphical abstract Schematic figure	1975:2009	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).	1975:2232	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	17	47	theme	red	2312:2314	arg1	MNP-SPE					2303:2309	MNP-SPE	2303:2309	MNP-SPE (red voltammogram)	2303:2328	Improved response of CHMNP-SPE (black voltammogram) in comparison to MNP-SPE (red voltammogram) was attributed to the protection of MNP from oxidation.
32388628	17	47	theme	red	2312:2314	arg1	voltammogram					2316:2327	red voltammogram	2312:2327	red voltammogram	2312:2327	Improved response of CHMNP-SPE (black voltammogram) in comparison to MNP-SPE (red voltammogram) was attributed to the protection of MNP from oxidation.
32388628	9	48	theme	0.1-0.8 μM	1205:1214	arg1	range					1233:1237	the 0.1-0.8 μM EP concentration range	1201:1237	the 0.1-0.8 μM EP concentration range	1201:1237	Response is linear in the 0.1-0.8 μM EP concentration range, at 0.03 V (vs. pseudo-Ag/AgCl), and the detection limit is 25 nM for the MNP-SPE.
32388628	9	48	theme	0.1-0.8 μM	1205:1214	arg1	at 0.03 V					1240:1248	at 0.03 V	1240:1248	at 0.03 V (vs. pseudo-Ag/AgCl)	1240:1269	Response is linear in the 0.1-0.8 μM EP concentration range, at 0.03 V (vs. pseudo-Ag/AgCl), and the detection limit is 25 nM for the MNP-SPE.
32388628	9	49	theme	concentration	1219:1231	arg1	range					1233:1237	the 0.1-0.8 μM EP concentration range	1201:1237	the 0.1-0.8 μM EP concentration range	1201:1237	Response is linear in the 0.1-0.8 μM EP concentration range, at 0.03 V (vs. pseudo-Ag/AgCl), and the detection limit is 25 nM for the MNP-SPE.
32388628	9	49	theme	concentration	1219:1231	arg1	at 0.03 V					1240:1248	at 0.03 V	1240:1248	at 0.03 V (vs. pseudo-Ag/AgCl)	1240:1269	Response is linear in the 0.1-0.8 μM EP concentration range, at 0.03 V (vs. pseudo-Ag/AgCl), and the detection limit is 25 nM for the MNP-SPE.
32388628	6	50	theme	electrochemical	849:863	arg1	responses					865:873	better electrochemical responses	842:873	better electrochemical responses	842:873	The CHMNP-SPE is found to have better electrochemical responses in comparison to the MNP-SPE.
32388628	14	51	theme	EP	1872:1873	arg1	current					1880:1886	its EP peak current	1868:1886	its EP peak current	1868:1886	The EP peak currents were found to decrease by only 4% for the CHMNP-SPE, while the MNP-SPE lost 23% of its EP peak current.
32388628	17	52	from	response	2243:2250	arg1	comparison					2289:2298	comparison	2289:2298	comparison to MNP-SPE (red voltammogram)	2289:2328	Improved response of CHMNP-SPE (black voltammogram) in comparison to MNP-SPE (red voltammogram) was attributed to the protection of MNP from oxidation.
32388628	13	53	theme	5 months	1754:1761	arg1	period					1744:1749	a period	1742:1749	a period of 5 months	1742:1761	The stability of the respective sensors was investigated and compared over a period of 5 months.
32388628	14	54	theme	lost 23	1856:1862	arg1	current					1880:1886	its EP peak current	1868:1886	its EP peak current	1868:1886	The EP peak currents were found to decrease by only 4% for the CHMNP-SPE, while the MNP-SPE lost 23% of its EP peak current.
32388628	14	54	theme	lost 23	1856:1862	arg1	%					1863:1863	the MNP-SPE lost 23%	1844:1863	the MNP-SPE lost 23% of its EP peak current	1844:1886	The EP peak currents were found to decrease by only 4% for the CHMNP-SPE, while the MNP-SPE lost 23% of its EP peak current.
32388628	0	55	theme	comparative	184:194	arg1	study					196:200	a comparative study	182:200	a comparative study	182:200	Screen-printed disposable electrodes using graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing: a comparative study.
32388628	1	56	theme	graphite-polyurethane	260:280	arg1	composites					282:291	graphite-polyurethane composites	260:291	graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE)	260:394	Disposable screen-printed electrodes based on the use of graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE) are described.
32388628	16	57	theme	magnetite	2145:2153	arg1	CHMNPs					2170:2175	CHMNPs	2170:2175	CHMNPs	2170:2175	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	16	57	theme	magnetite	2145:2153	arg1	nanoparticles					2155:2167	chitosan-coated magnetite nanoparticles	2129:2167	chitosan-coated magnetite nanoparticles (CHMNPs)	2129:2176	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	12	58	theme	95.6-102.2	1591:1600	arg1	%					1601:1601	%	1601:1601	%	1601:1601	Recoveries from spiked samples are in the 95.6-102.2% range for the CHMNP-SPE and in the 98.3-109% range for MNP-SPE.
32388628	16	59	theme	graphite-polyurethane	2032:2052	arg1	electrode					2079:2087	a graphite-polyurethane screen-printed composite electrode	2030:2087	a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs)	2030:2176	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	11	60	theme	EP	1488:1489	arg1	quantification					1470:1483	the quantification	1466:1483	the quantification of EP	1466:1489	The devices were used for the quantification of EP in synthetic urine and in cerebrospinal synthetic fluids.
32388628	7	61	theme	potential	1034:1042	arg1	fields					1044:1049	different applied potential fields	1016:1049	different applied potential fields	1016:1049	This is assumed to be due to the chitosan coating which also protects the MNPs from oxidation under air and at different applied potential fields.
32388628	0	62	theme	magnetite	120:128	arg1	nanoparticles					130:142	magnetite and chitosan-coated magnetite nanoparticles	90:142	magnetite and chitosan-coated magnetite nanoparticles	90:142	Screen-printed disposable electrodes using graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing: a comparative study.
32388628	12	63	from	samples	1572:1578	arg1	Recoveries					1549:1558	Recoveries	1549:1558	Recoveries from spiked samples	1549:1578	Recoveries from spiked samples are in the 95.6-102.2% range for the CHMNP-SPE and in the 98.3-109% range for MNP-SPE.
32388628	7	64	theme	different	1016:1024	arg1	fields					1044:1049	different applied potential fields	1016:1049	different applied potential fields	1016:1049	This is assumed to be due to the chitosan coating which also protects the MNPs from oxidation under air and at different applied potential fields.
32388628	1	65	theme	Disposable	203:212	arg1	electrodes					229:238	Disposable screen-printed electrodes	203:238	Disposable screen-printed electrodes based on the use of graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE)	203:394	Disposable screen-printed electrodes based on the use of graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE) are described.
32388628	16	66	theme	modification	2014:2025	arg1	figure					2004:2009	Graphical abstract Schematic figure	1975:2009	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).	1975:2232	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	11	67	theme	synthetic	1494:1502	arg1	urine					1504:1508	synthetic urine	1494:1508	synthetic urine	1494:1508	The devices were used for the quantification of EP in synthetic urine and in cerebrospinal synthetic fluids.
32388628	5	68	theme	epinephrine	793:803	arg1	sensing					782:788	sensing	782:788	sensing of epinephrine (EP)	782:808	The electrodes were tested for their performance towards sensing of epinephrine (EP).
32388628	16	69	theme	epinephrine	2216:2226	arg1	determination					2199:2211	the voltammetric determination	2182:2211	the voltammetric determination of epinephrine (EP)	2182:2231	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	0	70	theme	epinephrine	161:171	arg1	sensing					173:179	voltammetric epinephrine sensing	148:179	voltammetric epinephrine sensing	148:179	Screen-printed disposable electrodes using graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing: a comparative study.
32388628	12	71	theme	98.3-109	1638:1645	arg1	%					1646:1646	%	1646:1646	%	1646:1646	Recoveries from spiked samples are in the 95.6-102.2% range for the CHMNP-SPE and in the 98.3-109% range for MNP-SPE.
32388628	17	72	theme	Improved	2234:2241	arg1	response					2243:2250	Improved response	2234:2250	Improved response of CHMNP-SPE (black voltammogram) in comparison to MNP-SPE (red voltammogram)	2234:2328	Improved response of CHMNP-SPE (black voltammogram) in comparison to MNP-SPE (red voltammogram) was attributed to the protection of MNP from oxidation.
32388628	16	73	theme	screen-printed	2054:2067	arg1	electrode					2079:2087	a graphite-polyurethane screen-printed composite electrode	2030:2087	a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs)	2030:2176	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	0	74	theme	disposable	15:24	arg1	electrodes					26:35	Screen-printed disposable electrodes	0:35	Screen-printed disposable electrodes using graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing	0:179	Screen-printed disposable electrodes using graphite-polyurethane composites modified with magnetite and chitosan-coated magnetite nanoparticles for voltammetric epinephrine sensing: a comparative study.
32388628	13	75	dep	investigated	1711:1722	arg1	and compared					1724:1735	and compared	1724:1735	was investigated and compared over a period of 5 months	1707:1761	The stability of the respective sensors was investigated and compared over a period of 5 months.
32388628	16	76	theme	electrode	2079:2087	arg1	modification					2014:2025	modification	2014:2025	modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs)	2014:2176	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	1	77	theme	magnetite	360:368	arg1	nanoparticles					370:382	chitosan-coated magnetite nanoparticles	344:382	chitosan-coated magnetite nanoparticles (CHMNP-SPE)	344:394	Disposable screen-printed electrodes based on the use of graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE) are described.
32388628	1	77	theme	magnetite	360:368	arg1	CHMNP-SPE					385:393	CHMNP-SPE	385:393	CHMNP-SPE	385:393	Disposable screen-printed electrodes based on the use of graphite-polyurethane composites modified with magnetite nanoparticles (MNP-SPE) or chitosan-coated magnetite nanoparticles (CHMNP-SPE) are described.
32388628	16	78	with	electrode	2079:2087	arg1	CHMNPs					2170:2175	CHMNPs	2170:2175	CHMNPs	2170:2175	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	16	78	with	electrode	2079:2087	arg1	nanoparticles					2155:2167	chitosan-coated magnetite nanoparticles	2129:2167	chitosan-coated magnetite nanoparticles (CHMNPs)	2129:2176	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	16	78	with	electrode	2079:2087	arg1	MNPs					2119:2122	MNPs	2119:2122	MNPs	2119:2122	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	16	78	with	electrode	2079:2087	arg1	nanoparticles					2104:2116	magnetite nanoparticles	2094:2116	magnetite nanoparticles (MNPs)	2094:2123	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	10	79	theme	linear	1326:1331	arg1	0.1-0.6 μM					1364:1373	0.1-0.6 μM	1364:1373	0.1-0.6 μM	1364:1373	The linear response for the CHMNP-SPE was 0.1-0.6 μM, at 0.0 V (vs. pseudo-Ag/AgCl), and a LOD of 14 nM was achieved.
32388628	10	79	theme	linear	1326:1331	arg1	response					1333:1340	The linear response	1322:1340	The linear response for the CHMNP-SPE	1322:1358	The linear response for the CHMNP-SPE was 0.1-0.6 μM, at 0.0 V (vs. pseudo-Ag/AgCl), and a LOD of 14 nM was achieved.
32388628	17	80	theme	MNP	2366:2368	arg1	protection					2352:2361	the protection	2348:2361	the protection of MNP from oxidation	2348:2383	Improved response of CHMNP-SPE (black voltammogram) in comparison to MNP-SPE (red voltammogram) was attributed to the protection of MNP from oxidation.
32388628	14	81	theme	peak	1771:1774	arg1	currents					1776:1783	The EP peak currents	1764:1783	The EP peak currents	1764:1783	The EP peak currents were found to decrease by only 4% for the CHMNP-SPE, while the MNP-SPE lost 23% of its EP peak current.
32388628	8	82	theme	time	1154:1157	arg1	optimization					1124:1135	optimization	1124:1135	optimization of equilibration time and DPV parameters	1124:1176	The performances of the MNP-SPE and CHMNP-SPE were studied by DPV after optimization of equilibration time and DPV parameters.
32388628	4	83	theme	MNP	597:599	arg1	percentage					601:610	the MNP percentage	593:610	the MNP percentage	593:610	After optimization of the MNP percentage in MNP-SPE, the materials were electrochemically characterized by cyclic voltammetry, EIS, and chronocoulometry.
32388628	16	84	theme	abstract	1985:1992	arg1	figure					2004:2009	Graphical abstract Schematic figure	1975:2009	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).	1975:2232	Graphical abstract Schematic figure of modification of a graphite-polyurethane screen-printed composite electrode with magnetite nanoparticles (MNPs) and chitosan-coated magnetite nanoparticles (CHMNPs) for the voltammetric determination of epinephrine (EP).
32388628	8	85	theme	DPV	1163:1165	arg1	parameters					1167:1176	DPV parameters	1163:1176	DPV parameters	1163:1176	The performances of the MNP-SPE and CHMNP-SPE were studied by DPV after optimization of equilibration time and DPV parameters.
32388628	7	86	theme	chitosan	938:945	arg1	coating					947:953	the chitosan coating	934:953	the chitosan coating which also protects the MNPs from oxidation under air and at different applied potential fields	934:1049	This is assumed to be due to the chitosan coating which also protects the MNPs from oxidation under air and at different applied potential fields.
32388628	14	87	theme	current	1880:1886	arg1	current					1880:1886	its EP peak current	1868:1886	its EP peak current	1868:1886	The EP peak currents were found to decrease by only 4% for the CHMNP-SPE, while the MNP-SPE lost 23% of its EP peak current.
32388628	14	87	theme	current	1880:1886	arg1	%					1863:1863	the MNP-SPE lost 23%	1844:1863	the MNP-SPE lost 23% of its EP peak current	1844:1886	The EP peak currents were found to decrease by only 4% for the CHMNP-SPE, while the MNP-SPE lost 23% of its EP peak current.
32388628	4	88	theme	cyclic	678:683	arg1	voltammetry					685:695	cyclic voltammetry	678:695	cyclic voltammetry	678:695	After optimization of the MNP percentage in MNP-SPE, the materials were electrochemically characterized by cyclic voltammetry, EIS, and chronocoulometry.
34872407	6	0	theme	Bifidobacterium	656:670	arg1	species					672:678	Bifidobacterium species	656:678	Bifidobacterium species	656:678	The higher number of Bifidobacterium species and lower α and β diversity in breastfed infants are considered protective.
34872407	12	1	theme	microbiota	1337:1346	arg1	development					1322:1332	the development	1318:1332	the development of microbiota	1318:1346	The aim of this study is to examine the effect of breast milk on the development of microbiota, to present the results by scanning the literature.
34872407	9	2	dep	promote	941:947	arg1	prevent					986:992	prevent	986:992	prevent the adhesion of viruses to the colon	986:1029	These protective effects are to promote the growth of intestinal microbiota, prevent the adhesion of viruses to the colon, promote the growth of Bifidobacterium with its prebiotic effect.
34872407	9	2	dep	promote	941:947	arg1	promote					1032:1038	promote	1032:1038	promote the growth of Bifidobacterium with its prebiotic effect	1032:1094	These protective effects are to promote the growth of intestinal microbiota, prevent the adhesion of viruses to the colon, promote the growth of Bifidobacterium with its prebiotic effect.
34872407	4	3	from	infants	531:537	arg1	different					504:512	different	504:512	different	504:512	The microbiota compositions of breastfed infants are different from formula-fed infants.
34872407	4	3	from	infants	531:537	arg1	compositions					466:477	The microbiota compositions	451:477	The microbiota compositions of breastfed infants	451:498	The microbiota compositions of breastfed infants are different from formula-fed infants.
34872407	11	4	theme	gut	1217:1219	arg1	microbiota					1221:1230	the gut microbiota	1213:1230	the gut microbiota	1213:1230	Another component that shapes the gut microbiota is HM glycoproteins.
34872407	5	5	theme	Breast	540:545	arg1	oligosaccharides					552:567	Breast milk oligosaccharides	540:567	Breast milk oligosaccharides	540:567	Breast milk oligosaccharides play an important role in the development of infants' microbiota.
34872407	7	6	from	effects	814:820	arg1	health					825:830	health	825:830	health	825:830	A dysbiosis occurring in the microbiota can cause adverse effects on health.
34872407	9	7	theme	viruses	1010:1016	arg1	adhesion					998:1005	the adhesion	994:1005	the adhesion of viruses to the colon	994:1029	These protective effects are to promote the growth of intestinal microbiota, prevent the adhesion of viruses to the colon, promote the growth of Bifidobacterium with its prebiotic effect.
34872407	11	8	theme	HM	1235:1236	arg1	glycoproteins					1238:1250	HM glycoproteins	1235:1250	HM glycoproteins	1235:1250	Another component that shapes the gut microbiota is HM glycoproteins.
34872407	5	9	theme	milk	547:550	arg1	oligosaccharides					552:567	Breast milk oligosaccharides	540:567	Breast milk oligosaccharides	540:567	Breast milk oligosaccharides play an important role in the development of infants' microbiota.
34872407	2	10	contain	has	223:225	arg1	microbiota					212:221	the intestinal microbiota	197:221	the intestinal microbiota	197:221	It is known that the intestinal microbiota has an important role in the maturation of the immune system, also in the prevention of diseases that occur in newborn, childhood, adulthood.
34872407	2	10	contain	has	223:225	arg2	role					240:243	an important role	227:243	an important role	227:243	It is known that the intestinal microbiota has an important role in the maturation of the immune system, also in the prevention of diseases that occur in newborn, childhood, adulthood.
34872407	1	11	dep	begins	102:107	arg1	changes					145:151	changes	145:151	changes depending on many factors	145:177	The intestinal microbiota begins to take shape in the mother's womb, changes depending on many factors.
34872407	7	12	theme	adverse	806:812	arg1	effects					814:820	adverse effects	806:820	adverse effects on health	806:830	A dysbiosis occurring in the microbiota can cause adverse effects on health.
34872407	4	13	theme	formula-fed	519:529	arg1	infants					531:537	formula-fed infants	519:537	formula-fed infants	519:537	The microbiota compositions of breastfed infants are different from formula-fed infants.
34872407	6	14	from	number	646:651	arg1	infants					721:727	breastfed infants	711:727	breastfed infants	711:727	The higher number of Bifidobacterium species and lower α and β diversity in breastfed infants are considered protective.
34872407	6	15	theme	higher	639:644	arg1	number					646:651	The higher number	635:651	The higher number of Bifidobacterium species	635:678	The higher number of Bifidobacterium species and lower α and β diversity in breastfed infants are considered protective.
34872407	9	16	theme	protective	915:924	arg1	effects					926:932	These protective effects	909:932	These protective effects	909:932	These protective effects are to promote the growth of intestinal microbiota, prevent the adhesion of viruses to the colon, promote the growth of Bifidobacterium with its prebiotic effect.
34872407	5	17	theme	important	577:585	arg1	role					587:590	an important role	574:590	an important role	574:590	Breast milk oligosaccharides play an important role in the development of infants' microbiota.
34872407	3	18	from	development	401:411	arg1	infants					430:436	infants	430:436	infants after birth	430:448	Nutrition is the main factor on the development of microbiota in infants after birth.
34872407	12	19	theme	breast	1303:1308	arg1	milk					1310:1313	breast milk	1303:1313	breast milk	1303:1313	The aim of this study is to examine the effect of breast milk on the development of microbiota, to present the results by scanning the literature.
34872407	11	20	gly	glycoproteins	1238:1250	arg1	glycoproteins					1238:1250	HM glycoproteins	1235:1250	HM glycoproteins	1235:1250	Another component that shapes the gut microbiota is HM glycoproteins.
34872407	4	21	theme	breastfed	482:490	arg1	infants					492:498	breastfed infants	482:498	breastfed infants	482:498	The microbiota compositions of breastfed infants are different from formula-fed infants.
34872407	6	22	theme	breastfed	711:719	arg1	infants					721:727	breastfed infants	711:727	breastfed infants	711:727	The higher number of Bifidobacterium species and lower α and β diversity in breastfed infants are considered protective.
34872407	8	23	theme	milk	839:842	arg1	oligosaccharides					844:859	Human milk oligosaccharides	833:859	Human milk oligosaccharides	833:859	Human milk oligosaccharides also have protective effects on the microbiota.
34872407	2	24	theme	diseases	311:318	arg1	prevention					297:306	the prevention	293:306	the prevention of diseases that occur in newborn, childhood, adulthood	293:362	It is known that the intestinal microbiota has an important role in the maturation of the immune system, also in the prevention of diseases that occur in newborn, childhood, adulthood.
34872407	0	25	theme	human	25:29	arg1	milk					31:34	human milk	25:34	human milk	25:34	The relationship between human milk, a functional nutrient, and microbiota.
34872407	10	26	contain	have	1158:1161	arg1	acids					1115:1119	Short-chain fatty acids	1097:1119	Short-chain fatty acids resulting from their digestion, also	1097:1156	Short-chain fatty acids resulting from their digestion, also have protective effects.
34872407	10	26	contain	have	1158:1161	arg2	effects					1174:1180	protective effects	1163:1180	protective effects	1163:1180	Short-chain fatty acids resulting from their digestion, also have protective effects.
34872407	1	27	theme	intestinal	80:89	arg1	microbiota					91:100	The intestinal microbiota	76:100	The intestinal microbiota	76:100	The intestinal microbiota begins to take shape in the mother's womb, changes depending on many factors.
34872407	8	28	theme	Human	833:837	arg1	oligosaccharides					844:859	Human milk oligosaccharides	833:859	Human milk oligosaccharides	833:859	Human milk oligosaccharides also have protective effects on the microbiota.
34872407	2	29	theme	important	230:238	arg1	role					240:243	an important role	227:243	an important role	227:243	It is known that the intestinal microbiota has an important role in the maturation of the immune system, also in the prevention of diseases that occur in newborn, childhood, adulthood.
34872407	9	30	with	growth	1044:1049	arg1	effect					1089:1094	its prebiotic effect	1075:1094	its prebiotic effect	1075:1094	These protective effects are to promote the growth of intestinal microbiota, prevent the adhesion of viruses to the colon, promote the growth of Bifidobacterium with its prebiotic effect.
34872407	12	31	theme	milk	1310:1313	arg1	effect					1293:1298	the effect	1289:1298	the effect of breast milk on the development of microbiota	1289:1346	The aim of this study is to examine the effect of breast milk on the development of microbiota, to present the results by scanning the literature.
34872407	1	32	theme	many	166:169	arg1	factors					171:177	many factors	166:177	many factors	166:177	The intestinal microbiota begins to take shape in the mother's womb, changes depending on many factors.
34872407	4	33	theme	infants	492:498	arg1	different					504:512	different	504:512	different	504:512	The microbiota compositions of breastfed infants are different from formula-fed infants.
34872407	4	33	theme	infants	492:498	arg1	compositions					466:477	The microbiota compositions	451:477	The microbiota compositions of breastfed infants	451:498	The microbiota compositions of breastfed infants are different from formula-fed infants.
34872407	6	34	from	α	690:690	arg1	infants					721:727	breastfed infants	711:727	breastfed infants	711:727	The higher number of Bifidobacterium species and lower α and β diversity in breastfed infants are considered protective.
34872407	12	35	from	effect	1293:1298	arg1	development					1322:1332	the development	1318:1332	the development of microbiota	1318:1346	The aim of this study is to examine the effect of breast milk on the development of microbiota, to present the results by scanning the literature.
34872407	10	36	theme	fatty	1109:1113	arg1	acids					1115:1119	Short-chain fatty acids	1097:1119	Short-chain fatty acids resulting from their digestion, also	1097:1156	Short-chain fatty acids resulting from their digestion, also have protective effects.
34872407	8	37	theme	protective	871:880	arg1	effects					882:888	protective effects	871:888	protective effects	871:888	Human milk oligosaccharides also have protective effects on the microbiota.
34872407	3	38	theme	main	382:385	arg1	Nutrition					365:373	Nutrition	365:373	Nutrition	365:373	Nutrition is the main factor on the development of microbiota in infants after birth.
34872407	3	38	theme	main	382:385	arg1	factor					387:392	the main factor	378:392	the main factor on the development of microbiota in infants after birth	378:448	Nutrition is the main factor on the development of microbiota in infants after birth.
34872407	0	39	theme	functional	39:48	arg1	nutrient					50:57	a functional nutrient	37:57	a functional nutrient	37:57	The relationship between human milk, a functional nutrient, and microbiota.
34872407	10	40	theme	Short-chain	1097:1107	arg1	acids					1115:1119	Short-chain fatty acids	1097:1119	Short-chain fatty acids resulting from their digestion, also	1097:1156	Short-chain fatty acids resulting from their digestion, also have protective effects.
34872407	6	41	theme	β	696:696	arg1	diversity					698:706	β diversity	696:706	β diversity	696:706	The higher number of Bifidobacterium species and lower α and β diversity in breastfed infants are considered protective.
34872407	8	42	contain	have	866:869	arg1	oligosaccharides					844:859	Human milk oligosaccharides	833:859	Human milk oligosaccharides	833:859	Human milk oligosaccharides also have protective effects on the microbiota.
34872407	8	42	contain	have	866:869	arg2	effects					882:888	protective effects	871:888	protective effects	871:888	Human milk oligosaccharides also have protective effects on the microbiota.
34872407	3	43	from	factor	387:392	arg1	development					401:411	the development	397:411	the development of microbiota in infants after birth	397:448	Nutrition is the main factor on the development of microbiota in infants after birth.
34872407	3	44	theme	microbiota	416:425	arg1	development					401:411	the development	397:411	the development of microbiota in infants after birth	397:448	Nutrition is the main factor on the development of microbiota in infants after birth.
34872407	9	45	theme	intestinal	963:972	arg1	microbiota					974:983	intestinal microbiota	963:983	intestinal microbiota	963:983	These protective effects are to promote the growth of intestinal microbiota, prevent the adhesion of viruses to the colon, promote the growth of Bifidobacterium with its prebiotic effect.
34872407	4	46	theme	microbiota	455:464	arg1	different					504:512	different	504:512	different	504:512	The microbiota compositions of breastfed infants are different from formula-fed infants.
34872407	4	46	theme	microbiota	455:464	arg1	compositions					466:477	The microbiota compositions	451:477	The microbiota compositions of breastfed infants	451:498	The microbiota compositions of breastfed infants are different from formula-fed infants.
34872407	5	47	theme	microbiota	623:632	arg1	development					599:609	the development	595:609	the development of infants' microbiota	595:632	Breast milk oligosaccharides play an important role in the development of infants' microbiota.
34872407	9	48	theme	prebiotic	1079:1087	arg1	effect					1089:1094	its prebiotic effect	1075:1094	its prebiotic effect	1075:1094	These protective effects are to promote the growth of intestinal microbiota, prevent the adhesion of viruses to the colon, promote the growth of Bifidobacterium with its prebiotic effect.
34872407	2	49	theme	system	277:282	arg1	maturation					252:261	the maturation	248:261	the maturation of the immune system	248:282	It is known that the intestinal microbiota has an important role in the maturation of the immune system, also in the prevention of diseases that occur in newborn, childhood, adulthood.
34872407	9	50	theme	microbiota	974:983	arg1	growth					953:958	the growth	949:958	the growth of intestinal microbiota	949:983	These protective effects are to promote the growth of intestinal microbiota, prevent the adhesion of viruses to the colon, promote the growth of Bifidobacterium with its prebiotic effect.
34872407	9	51	theme	Bifidobacterium	1054:1068	arg1	growth					1044:1049	the growth	1040:1049	the growth of Bifidobacterium with its prebiotic effect	1040:1094	These protective effects are to promote the growth of intestinal microbiota, prevent the adhesion of viruses to the colon, promote the growth of Bifidobacterium with its prebiotic effect.
34872407	6	52	theme	lower	684:688	arg1	α					690:690	lower α	684:690	lower α	684:690	The higher number of Bifidobacterium species and lower α and β diversity in breastfed infants are considered protective.
34872407	2	53	theme	immune	270:275	arg1	system					277:282	the immune system	266:282	the immune system	266:282	It is known that the intestinal microbiota has an important role in the maturation of the immune system, also in the prevention of diseases that occur in newborn, childhood, adulthood.
34872407	6	54	from	diversity	698:706	arg1	infants					721:727	breastfed infants	711:727	breastfed infants	711:727	The higher number of Bifidobacterium species and lower α and β diversity in breastfed infants are considered protective.
34872407	2	55	theme	intestinal	201:210	arg1	microbiota					212:221	the intestinal microbiota	197:221	the intestinal microbiota	197:221	It is known that the intestinal microbiota has an important role in the maturation of the immune system, also in the prevention of diseases that occur in newborn, childhood, adulthood.
34872407	10	56	theme	protective	1163:1172	arg1	effects					1174:1180	protective effects	1163:1180	protective effects	1163:1180	Short-chain fatty acids resulting from their digestion, also have protective effects.
34872407	12	57	theme	study	1269:1273	arg1	aim					1257:1259	The aim	1253:1259	The aim of this study	1253:1273	The aim of this study is to examine the effect of breast milk on the development of microbiota, to present the results by scanning the literature.
34872407	6	58	theme	species	672:678	arg1	number					646:651	The higher number	635:651	The higher number of Bifidobacterium species	635:678	The higher number of Bifidobacterium species and lower α and β diversity in breastfed infants are considered protective.
34872407	6	58	theme	species	672:678	arg1	α					690:690	lower α	684:690	lower α	684:690	The higher number of Bifidobacterium species and lower α and β diversity in breastfed infants are considered protective.
34872407	6	58	theme	species	672:678	arg1	diversity					698:706	β diversity	696:706	β diversity	696:706	The higher number of Bifidobacterium species and lower α and β diversity in breastfed infants are considered protective.
33406734	1	0	from	impact	187:192	arg1	interplay					215:223	the host-pathogen interplay	197:223	the host-pathogen interplay in many infectious diseases	197:251	Glycans display increasingly recognized roles in pathological contexts, however, their impact in the host-pathogen interplay in many infectious diseases remains largely unknown.
33406734	2	1	theme	fatal	338:342	arg1	diseases					344:351	the ten most fatal diseases	325:351	the ten most fatal diseases	325:351	This is the case for tuberculosis (TB), one of the ten most fatal diseases worldwide, caused by infection of the bacteria Mycobacterium tuberculosis.
33406734	0	2	theme	Lung	83:86	arg1	Epithelium					88:97	the Lung Epithelium	79:97	the Lung Epithelium	79:97	Mycobacterium tuberculosis Infection Up-Regulates Sialyl Lewis X Expression in the Lung Epithelium.
33406734	5	3	theme	transcriptomic	891:904	arg1	signature					906:914	an altered lung tissue transcriptomic signature	868:914	an altered lung tissue transcriptomic signature	868:914	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	6	4	theme	host	1162:1165	arg1	response					1167:1174	the host response	1158:1174	the host response to M. tuberculosis infection	1158:1203	This study provides novel insights into previously unappreciated molecular mechanisms involving glycosylation, which modulate the host response to M. tuberculosis infection, possibly contributing to shape TB disease outcome.
33406734	4	5	from	expression	690:699	arg1	epithelium					770:779	the lung epithelium	761:779	the lung epithelium	761:779	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	5	6	theme	tissue	884:889	arg1	signature					906:914	an altered lung tissue transcriptomic signature	868:914	an altered lung tissue transcriptomic signature	868:914	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	6	7	theme	disease	1240:1246	arg1	outcome					1248:1254	shape TB disease outcome	1231:1254	shape TB disease outcome	1231:1254	This study provides novel insights into previously unappreciated molecular mechanisms involving glycosylation, which modulate the host response to M. tuberculosis infection, possibly contributing to shape TB disease outcome.
33406734	4	8	theme	increased	680:688	arg1	expression					690:699	an increased expression	677:699	an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium	677:779	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	3	9	theme	M.	549:550	arg1	infection					565:573	M. tuberculosis infection	549:573	M. tuberculosis infection	549:573	We have recently reported that perturbing the core-2 O-glycans biosynthetic pathway increases the host susceptibility to M. tuberculosis infection, by disrupting the neutrophil homeostasis and enhancing lung pathology.
33406734	5	10	from	increase	818:825	arg1	epitope					842:848	SLeX glycan epitope	830:848	SLeX glycan epitope	830:848	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	3	11	theme	tuberculosis	552:563	arg1	infection					565:573	M. tuberculosis infection	549:573	M. tuberculosis infection	549:573	We have recently reported that perturbing the core-2 O-glycans biosynthetic pathway increases the host susceptibility to M. tuberculosis infection, by disrupting the neutrophil homeostasis and enhancing lung pathology.
33406734	1	12	theme	pathological	149:160	arg1	contexts					162:169	pathological contexts	149:169	pathological contexts	149:169	Glycans display increasingly recognized roles in pathological contexts, however, their impact in the host-pathogen interplay in many infectious diseases remains largely unknown.
33406734	1	13	theme	recognized	129:138	arg1	roles					140:144	increasingly recognized roles	116:144	increasingly recognized roles	116:144	Glycans display increasingly recognized roles in pathological contexts, however, their impact in the host-pathogen interplay in many infectious diseases remains largely unknown.
33406734	5	14	theme	glycan	835:840	arg1	epitope					842:848	SLeX glycan epitope	830:848	SLeX glycan epitope	830:848	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	4	15	theme	lung	765:768	arg1	epithelium					770:779	the lung epithelium	761:779	the lung epithelium	761:779	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	6	16	theme	molecular	1097:1105	arg1	mechanisms					1107:1116	previously unappreciated molecular mechanisms	1072:1116	previously unappreciated molecular mechanisms involving glycosylation, which modulate the host response to M. tuberculosis infection, possibly contributing to shape TB disease outcome	1072:1254	This study provides novel insights into previously unappreciated molecular mechanisms involving glycosylation, which modulate the host response to M. tuberculosis infection, possibly contributing to shape TB disease outcome.
33406734	0	17	theme	tuberculosis	14:25	arg1	Infection					27:35	Mycobacterium tuberculosis Infection	0:35	Mycobacterium tuberculosis Infection	0:35	Mycobacterium tuberculosis Infection Up-Regulates Sialyl Lewis X Expression in the Lung Epithelium.
33406734	3	18	theme	host	526:529	arg1	susceptibility					531:544	the host susceptibility	522:544	the host susceptibility to M. tuberculosis infection	522:573	We have recently reported that perturbing the core-2 O-glycans biosynthetic pathway increases the host susceptibility to M. tuberculosis infection, by disrupting the neutrophil homeostasis and enhancing lung pathology.
33406734	5	19	theme	genes	939:943	arg1	enzymes					955:961	genes codifying enzymes	939:961	genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway	939:1029	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	6	20	theme	unappreciated	1083:1095	arg1	mechanisms					1107:1116	previously unappreciated molecular mechanisms	1072:1116	previously unappreciated molecular mechanisms involving glycosylation, which modulate the host response to M. tuberculosis infection, possibly contributing to shape TB disease outcome	1072:1254	This study provides novel insights into previously unappreciated molecular mechanisms involving glycosylation, which modulate the host response to M. tuberculosis infection, possibly contributing to shape TB disease outcome.
33406734	0	21	theme	Mycobacterium	0:12	arg1	tuberculosis					14:25	Mycobacterium tuberculosis	0:25	Mycobacterium tuberculosis Infection	0:35	Mycobacterium tuberculosis Infection Up-Regulates Sialyl Lewis X Expression in the Lung Epithelium.
33406734	4	22	theme	structure	726:734	arg1	SLeX					752:755	SLeX	752:755	SLeX	752:755	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	4	22	theme	structure	726:734	arg1	X					749:749	the sialylated glycan structure Sialyl-Lewis X	704:749	the sialylated glycan structure Sialyl-Lewis X (SLeX)	704:756	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	4	23	theme	X	749:749	arg1	expression					690:699	an increased expression	677:699	an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium	677:779	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	5	24	theme	altered	871:877	arg1	signature					906:914	an altered lung tissue transcriptomic signature	868:914	an altered lung tissue transcriptomic signature	868:914	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	6	25	theme	TB	1237:1238	arg1	outcome					1248:1254	shape TB disease outcome	1231:1254	shape TB disease outcome	1231:1254	This study provides novel insights into previously unappreciated molecular mechanisms involving glycosylation, which modulate the host response to M. tuberculosis infection, possibly contributing to shape TB disease outcome.
33406734	4	26	gly	sialylated	708:717	arg1	SLeX					752:755	SLeX	752:755	SLeX	752:755	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	4	26	gly	sialylated	708:717	arg1	X					749:749	the sialylated glycan structure Sialyl-Lewis X	704:749	the sialylated glycan structure Sialyl-Lewis X (SLeX)	704:756	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	5	27	theme	enzymes	955:961	arg1	up-regulation					922:934	up-regulation	922:934	up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway	922:1029	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	1	28	theme	host-pathogen	201:213	arg1	interplay					215:223	the host-pathogen interplay	197:223	the host-pathogen interplay in many infectious diseases	197:251	Glycans display increasingly recognized roles in pathological contexts, however, their impact in the host-pathogen interplay in many infectious diseases remains largely unknown.
33406734	5	29	theme	codifying	945:953	arg1	enzymes					955:961	genes codifying enzymes	939:961	genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway	939:1029	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	2	30	theme	bacteria	391:398	arg1	infection					374:382	infection	374:382	infection of the bacteria	374:398	This is the case for tuberculosis (TB), one of the ten most fatal diseases worldwide, caused by infection of the bacteria Mycobacterium tuberculosis.
33406734	4	31	theme	sialylated	708:717	arg1	SLeX					752:755	SLeX	752:755	SLeX	752:755	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	4	31	theme	sialylated	708:717	arg1	X					749:749	the sialylated glycan structure Sialyl-Lewis X	704:749	the sialylated glycan structure Sialyl-Lewis X (SLeX)	704:756	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	5	32	theme	biosynthetic	1010:1021	arg1	pathway					1023:1029	the SLeX core-2 O-glycans biosynthetic pathway	984:1029	the SLeX core-2 O-glycans biosynthetic pathway	984:1029	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	6	33	theme	shape	1231:1235	arg1	outcome					1248:1254	shape TB disease outcome	1231:1254	shape TB disease outcome	1231:1254	This study provides novel insights into previously unappreciated molecular mechanisms involving glycosylation, which modulate the host response to M. tuberculosis infection, possibly contributing to shape TB disease outcome.
33406734	6	34	theme	novel	1052:1056	arg1	insights					1058:1065	novel insights	1052:1065	novel insights into previously unappreciated molecular mechanisms involving glycosylation, which modulate the host response to M. tuberculosis infection, possibly contributing to shape TB disease outcome	1052:1254	This study provides novel insights into previously unappreciated molecular mechanisms involving glycosylation, which modulate the host response to M. tuberculosis infection, possibly contributing to shape TB disease outcome.
33406734	0	35	theme	Sialyl	50:55	arg1	Lewis					57:61	Sialyl Lewis	50:61	Sialyl Lewis	50:61	Mycobacterium tuberculosis Infection Up-Regulates Sialyl Lewis X Expression in the Lung Epithelium.
33406734	1	36	theme	many	228:231	arg1	diseases					244:251	many infectious diseases	228:251	many infectious diseases	228:251	Glycans display increasingly recognized roles in pathological contexts, however, their impact in the host-pathogen interplay in many infectious diseases remains largely unknown.
33406734	5	37	theme	lung	879:882	arg1	signature					906:914	an altered lung tissue transcriptomic signature	868:914	an altered lung tissue transcriptomic signature	868:914	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	3	38	theme	O-glycans	481:489	arg1	pathway					504:510	the core-2 O-glycans biosynthetic pathway	470:510	the core-2 O-glycans biosynthetic pathway	470:510	We have recently reported that perturbing the core-2 O-glycans biosynthetic pathway increases the host susceptibility to M. tuberculosis infection, by disrupting the neutrophil homeostasis and enhancing lung pathology.
33406734	3	39	theme	neutrophil	594:603	arg1	homeostasis					605:615	the neutrophil homeostasis	590:615	the neutrophil homeostasis	590:615	We have recently reported that perturbing the core-2 O-glycans biosynthetic pathway increases the host susceptibility to M. tuberculosis infection, by disrupting the neutrophil homeostasis and enhancing lung pathology.
33406734	3	40	theme	biosynthetic	491:502	arg1	pathway					504:510	the core-2 O-glycans biosynthetic pathway	470:510	the core-2 O-glycans biosynthetic pathway	470:510	We have recently reported that perturbing the core-2 O-glycans biosynthetic pathway increases the host susceptibility to M. tuberculosis infection, by disrupting the neutrophil homeostasis and enhancing lung pathology.
33406734	4	41	theme	tuberculosis	789:800	arg1	infection					802:810	M. tuberculosis infection	786:810	M. tuberculosis infection	786:810	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	4	42	theme	glycan	719:724	arg1	SLeX					752:755	SLeX	752:755	SLeX	752:755	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	4	42	theme	glycan	719:724	arg1	X					749:749	the sialylated glycan structure Sialyl-Lewis X	704:749	the sialylated glycan structure Sialyl-Lewis X (SLeX)	704:756	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	5	43	theme	SLeX	988:991	arg1	pathway					1023:1029	the SLeX core-2 O-glycans biosynthetic pathway	984:1029	the SLeX core-2 O-glycans biosynthetic pathway	984:1029	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	4	44	theme	M.	786:787	arg1	infection					802:810	M. tuberculosis infection	786:810	M. tuberculosis infection	786:810	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	1	45	from	interplay	215:223	arg1	diseases					244:251	many infectious diseases	228:251	many infectious diseases	228:251	Glycans display increasingly recognized roles in pathological contexts, however, their impact in the host-pathogen interplay in many infectious diseases remains largely unknown.
33406734	4	46	theme	Sialyl-Lewis	736:747	arg1	SLeX					752:755	SLeX	752:755	SLeX	752:755	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	4	46	theme	Sialyl-Lewis	736:747	arg1	X					749:749	the sialylated glycan structure Sialyl-Lewis X	704:749	the sialylated glycan structure Sialyl-Lewis X (SLeX)	704:756	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	6	47	theme	M.	1179:1180	arg1	tuberculosis					1182:1193	M. tuberculosis	1179:1193	M. tuberculosis infection	1179:1203	This study provides novel insights into previously unappreciated molecular mechanisms involving glycosylation, which modulate the host response to M. tuberculosis infection, possibly contributing to shape TB disease outcome.
33406734	1	48	theme	infectious	233:242	arg1	diseases					244:251	many infectious diseases	228:251	many infectious diseases	228:251	Glycans display increasingly recognized roles in pathological contexts, however, their impact in the host-pathogen interplay in many infectious diseases remains largely unknown.
33406734	5	49	theme	core-2	993:998	arg1	pathway					1023:1029	the SLeX core-2 O-glycans biosynthetic pathway	984:1029	the SLeX core-2 O-glycans biosynthetic pathway	984:1029	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	3	50	theme	core-2	474:479	arg1	pathway					504:510	the core-2 O-glycans biosynthetic pathway	470:510	the core-2 O-glycans biosynthetic pathway	470:510	We have recently reported that perturbing the core-2 O-glycans biosynthetic pathway increases the host susceptibility to M. tuberculosis infection, by disrupting the neutrophil homeostasis and enhancing lung pathology.
33406734	4	51	theme	present	654:660	arg1	study					662:666	the present study	650:666	the present study	650:666	In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection.
33406734	5	52	theme	O-glycans	1000:1008	arg1	pathway					1023:1029	the SLeX core-2 O-glycans biosynthetic pathway	984:1029	the SLeX core-2 O-glycans biosynthetic pathway	984:1029	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	5	53	theme	SLeX	830:833	arg1	epitope					842:848	SLeX glycan epitope	830:848	SLeX glycan epitope	830:848	This increase in SLeX glycan epitope is accompanied by an altered lung tissue transcriptomic signature, with up-regulation of genes codifying enzymes that are involved in the SLeX core-2 O-glycans biosynthetic pathway.
33406734	2	54	theme	worldwide	353:361	arg1	diseases					344:351	the ten most fatal diseases	325:351	the ten most fatal diseases	325:351	This is the case for tuberculosis (TB), one of the ten most fatal diseases worldwide, caused by infection of the bacteria Mycobacterium tuberculosis.
33406734	6	55	theme	tuberculosis	1182:1193	arg1	infection					1195:1203	M. tuberculosis infection	1179:1203	M. tuberculosis infection	1179:1203	This study provides novel insights into previously unappreciated molecular mechanisms involving glycosylation, which modulate the host response to M. tuberculosis infection, possibly contributing to shape TB disease outcome.
33406734	3	56	theme	lung	631:634	arg1	pathology					636:644	lung pathology	631:644	lung pathology	631:644	We have recently reported that perturbing the core-2 O-glycans biosynthetic pathway increases the host susceptibility to M. tuberculosis infection, by disrupting the neutrophil homeostasis and enhancing lung pathology.
33406734	2	57	theme	diseases	344:351	arg1	one					318:320	one	318:320	one	318:320	This is the case for tuberculosis (TB), one of the ten most fatal diseases worldwide, caused by infection of the bacteria Mycobacterium tuberculosis.
33406734	2	57	theme	diseases	344:351	arg1	tuberculosis					299:310	tuberculosis	299:310	tuberculosis (TB)	299:315	This is the case for tuberculosis (TB), one of the ten most fatal diseases worldwide, caused by infection of the bacteria Mycobacterium tuberculosis.
33406734	2	57	theme	diseases	344:351	arg1	diseases					344:351	the ten most fatal diseases	325:351	the ten most fatal diseases	325:351	This is the case for tuberculosis (TB), one of the ten most fatal diseases worldwide, caused by infection of the bacteria Mycobacterium tuberculosis.
34960065	2	0	theme	IBS	415:417	arg1	participants					419:430	IBS participants	415:430	IBS participants	415:430	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	5	1	theme	mean	1020:1023	arg1	Results					955:961	Results	955:961	Results: Included participants were mainly women (75.4%) and the mean age	955:1027	The association between FODMAPs and IBS was estimated through multivariable logistic regression models; (3) Results: Included participants were mainly women (75.4%) and the mean age was 43.4 ± 14.1 years.
34960065	5	1	theme	mean	1020:1023	arg1	age					1025:1027	the mean age	1016:1027	the mean age	1016:1027	The association between FODMAPs and IBS was estimated through multivariable logistic regression models; (3) Results: Included participants were mainly women (75.4%) and the mean age was 43.4 ± 14.1 years.
34960065	2	2	theme	cohort	525:530	arg1	study					532:536	the NutriNet-Santé cohort study	506:536	the NutriNet-Santé cohort study	506:536	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	3	3	theme	eligible	633:640	arg1	participants					642:653	27,949 eligible participants	626:653	27,949 eligible participants	626:653	Among them, 27,949 eligible participants had previously completed three 24-h recalls as well as anthropometrics, socio-demographical and lifestyle data.
34960065	2	4	theme	NutriNet-Santé	510:523	arg1	study					532:536	the NutriNet-Santé cohort study	506:536	the NutriNet-Santé cohort study	506:536	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	9	5	theme	IBS	1330:1332	arg1	severity					1334:1341	IBS severity	1330:1341	IBS severity	1330:1341	IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls.
34960065	1	6	from	Syndrome	343:350	arg1	foods					171:175	Specific foods	162:175	Specific foods	162:175	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	6	from	Syndrome	343:350	arg1	triggers					293:300	triggers	293:300	triggers of digestive symptoms in Irritable Bowel Syndrome (IBS)	293:356	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	6	from	Syndrome	343:350	arg1	di-					221:223	di-	221:223	di-	221:223	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	6	from	Syndrome	343:350	arg1	mono-saccharides					230:245	mono-saccharides	230:245	mono-saccharides	230:245	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	6	from	Syndrome	343:350	arg1	oligo-					213:218	fermentable oligo-	201:218	fermentable oligo-	201:218	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	6	7	theme	daily	1081:1085	arg1	intake					1087:1092	a mean daily intake	1074:1092	a mean daily intake of 19.4 ± 9.5 g/day	1074:1112	FODMAPs accounted for a mean daily intake of 19.4 ± 9.5 g/day.
34960065	2	8	theme	IBS-SSS	564:570	arg1	questionnaire					572:584	the Rome IV and IBS-SSS questionnaire	548:584	questionnaire	572:584	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	2	9	from	study	532:536	arg1	Participants					488:499	Participants	488:499	Participants from the NutriNet-Santé cohort study	488:536	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	9	10	theme	FODMAP	1381:1386	arg1	intakes					1388:1394	more frequent low FODMAP intakes	1363:1394	more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls	1363:1536	IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls.
34960065	9	10	theme	FODMAP	1381:1386	arg1	g/day					1400:1404	<9 g/day	1397:1404	<9 g/day	1397:1404	IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls.
34960065	2	11	theme	French	443:448	arg1	cohort					467:472	a large French population-based cohort	435:472	a large French population-based cohort	435:472	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	2	12	from	consumption	387:397	arg1	participants					419:430	IBS participants	415:430	IBS participants	415:430	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	2	12	from	consumption	387:397	arg1	cohort					467:472	a large French population-based cohort	435:472	a large French population-based cohort	435:472	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	2	12	from	consumption	387:397	arg1	controls					402:409	controls	402:409	controls	402:409	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	9	13	theme	FODMAPs	1464:1470	arg1	g					1459:1459	19 g	1456:1459	19 g of FODMAPs per day	1456:1478	IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls.
34960065	3	14	theme	lifestyle	751:759	arg1	recalls					691:697	three 24-h recalls	680:697	three 24-h recalls as well as anthropometrics	680:724	Among them, 27,949 eligible participants had previously completed three 24-h recalls as well as anthropometrics, socio-demographical and lifestyle data.
34960065	3	14	theme	lifestyle	751:759	arg1	data					761:764	socio-demographical and lifestyle data	727:764	socio-demographical and lifestyle data	727:764	Among them, 27,949 eligible participants had previously completed three 24-h recalls as well as anthropometrics, socio-demographical and lifestyle data.
34960065	0	15	theme	Bowel	94:98	arg1	Syndrome					100:107	Irritable Bowel Syndrome	84:107	Irritable Bowel Syndrome	84:107	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption and Irritable Bowel Syndrome in the French NutriNet-Santé Cohort.
34960065	1	16	theme	digestive	305:313	arg1	symptoms					315:322	digestive symptoms	305:322	digestive symptoms in Irritable Bowel Syndrome (IBS)	305:356	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	2	17	theme	Rome	552:555	arg1	IV					557:558	the Rome IV and IBS-SSS questionnaire	548:584	IV	557:558	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	9	18	dep	Conclusions	1412:1422	arg1	4					1409:1409	4	1409:1409	4	1409:1409	IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls.
34960065	8	19	dep	had	1235:1237	arg1	aOR					1283:1285	aOR	1283:1285	aOR	1283:1285	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	0	20	theme	Irritable	84:92	arg1	Syndrome					100:107	Irritable Bowel Syndrome	84:107	Irritable Bowel Syndrome	84:107	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption and Irritable Bowel Syndrome in the French NutriNet-Santé Cohort.
34960065	1	21	theme	symptoms	315:322	arg1	foods					171:175	Specific foods	162:175	Specific foods	162:175	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	21	theme	symptoms	315:322	arg1	triggers					293:300	triggers	293:300	triggers of digestive symptoms in Irritable Bowel Syndrome (IBS)	293:356	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	21	theme	symptoms	315:322	arg1	di-					221:223	di-	221:223	di-	221:223	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	21	theme	symptoms	315:322	arg1	mono-saccharides					230:245	mono-saccharides	230:245	mono-saccharides	230:245	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	21	theme	symptoms	315:322	arg1	oligo-					213:218	fermentable oligo-	201:218	fermentable oligo-	201:218	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	4	22	theme	Total	767:771	arg1	intake					780:785	Total FODMAP intake	767:785	Total FODMAP intake (in g/day)	767:796	Total FODMAP intake (in g/day) was computed using a specific composition table.
34960065	4	22	theme	Total	767:771	arg1	g/day					791:795	in g/day	788:795	in g/day	788:795	Total FODMAP intake (in g/day) was computed using a specific composition table.
34960065	2	23	theme	sectional	597:605	arg1	study					607:611	a cross sectional study	589:611	a cross sectional study	589:611	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	8	24	theme	confounding	1197:1207	arg1	factors					1209:1215	confounding factors	1197:1215	confounding factors	1197:1215	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	8	25	from	intakes	1245:1251	arg1	FODMAPs					1256:1262	FODMAPs	1256:1262	FODMAPs	1256:1262	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	2	26	theme	large	437:441	arg1	cohort					467:472	a large French population-based cohort	435:472	a large French population-based cohort	435:472	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	0	27	theme	Oligo-	12:17	arg1	Consumption					68:78	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption	0:78	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption	0:78	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption and Irritable Bowel Syndrome in the French NutriNet-Santé Cohort.
34960065	2	28	theme	cross	591:595	arg1	study					607:611	a cross sectional study	589:611	a cross sectional study	589:611	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	8	29	theme	IBS	1218:1220	arg1	participants					1222:1233	IBS participants	1218:1233	IBS participants	1218:1233	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	5	30	dep	years	1045:1049	arg1	3					952:952	3	952:952	3	952:952	The association between FODMAPs and IBS was estimated through multivariable logistic regression models; (3) Results: Included participants were mainly women (75.4%) and the mean age was 43.4 ± 14.1 years.
34960065	9	31	dep	intakes	1388:1394	arg1	Conclusions					1412:1422	Conclusions	1412:1422	more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls	1363:1536	IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls.
34960065	9	31	dep	intakes	1388:1394	arg1	tended					1438:1443	tended	1438:1443	tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls	1438:1536	IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls.
34960065	0	32	theme	Fermentable	0:10	arg1	Consumption					68:78	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption	0:78	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption	0:78	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption and Irritable Bowel Syndrome in the French NutriNet-Santé Cohort.
34960065	6	33	theme	g/day	1108:1112	arg1	intake					1087:1092	a mean daily intake	1074:1092	a mean daily intake of 19.4 ± 9.5 g/day	1074:1112	FODMAPs accounted for a mean daily intake of 19.4 ± 9.5 g/day.
34960065	4	34	theme	FODMAP	773:778	arg1	intake					780:785	Total FODMAP intake	767:785	Total FODMAP intake (in g/day)	767:796	Total FODMAP intake (in g/day) was computed using a specific composition table.
34960065	4	34	theme	FODMAP	773:778	arg1	g/day					791:795	in g/day	788:795	in g/day	788:795	Total FODMAP intake (in g/day) was computed using a specific composition table.
34960065	4	35	theme	in	788:789	arg1	intake					780:785	Total FODMAP intake	767:785	Total FODMAP intake (in g/day)	767:796	Total FODMAP intake (in g/day) was computed using a specific composition table.
34960065	4	35	theme	in	788:789	arg1	g/day					791:795	in g/day	788:795	in g/day	788:795	Total FODMAP intake (in g/day) was computed using a specific composition table.
34960065	0	36	theme	Di-	20:22	arg1	Consumption					68:78	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption	0:78	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption	0:78	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption and Irritable Bowel Syndrome in the French NutriNet-Santé Cohort.
34960065	6	37	theme	mean	1076:1079	arg1	intake					1087:1092	a mean daily intake	1074:1092	a mean daily intake of 19.4 ± 9.5 g/day	1074:1112	FODMAPs accounted for a mean daily intake of 19.4 ± 9.5 g/day.
34960065	9	38	theme	low	1377:1379	arg1	intakes					1388:1394	more frequent low FODMAP intakes	1363:1394	more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls	1363:1536	IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls.
34960065	9	38	theme	low	1377:1379	arg1	g/day					1400:1404	<9 g/day	1397:1404	<9 g/day	1397:1404	IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls.
34960065	1	39	theme	Specific	162:169	arg1	foods					171:175	Specific foods	162:175	Specific foods	162:175	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	39	theme	Specific	162:169	arg1	triggers					293:300	triggers	293:300	triggers of digestive symptoms in Irritable Bowel Syndrome (IBS)	293:356	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	39	theme	Specific	162:169	arg1	di-					221:223	di-	221:223	di-	221:223	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	39	theme	Specific	162:169	arg1	mono-saccharides					230:245	mono-saccharides	230:245	mono-saccharides	230:245	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	39	theme	Specific	162:169	arg1	oligo-					213:218	fermentable oligo-	201:218	fermentable oligo-	201:218	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	9	40	theme	frequent	1368:1375	arg1	intakes					1388:1394	more frequent low FODMAP intakes	1363:1394	more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls	1363:1536	IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls.
34960065	9	40	theme	frequent	1368:1375	arg1	g/day					1400:1404	<9 g/day	1397:1404	<9 g/day	1397:1404	IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls.
34960065	4	41	theme	composition	828:838	arg1	table					840:844	a specific composition table	817:844	a specific composition table	817:844	Total FODMAP intake (in g/day) was computed using a specific composition table.
34960065	1	42	theme	Irritable	327:335	arg1	Syndrome					343:350	Irritable Bowel Syndrome	327:350	Irritable Bowel Syndrome (IBS)	327:356	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	42	theme	Irritable	327:335	arg1	IBS					353:355	IBS	353:355	IBS	353:355	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	2	43	dep	completed	538:546	arg1	Methods					479:485	Methods	479:485	Methods	479:485	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	2	43	dep	completed	538:546	arg1	2					476:476	2	476:476	2	476:476	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	0	44	theme	French	116:121	arg1	Cohort					138:143	the French NutriNet-Santé Cohort	112:143	the French NutriNet-Santé Cohort	112:143	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption and Irritable Bowel Syndrome in the French NutriNet-Santé Cohort.
34960065	1	45	theme	Bowel	337:341	arg1	Syndrome					343:350	Irritable Bowel Syndrome	327:350	Irritable Bowel Syndrome (IBS)	327:356	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	45	theme	Bowel	337:341	arg1	IBS					353:355	IBS	353:355	IBS	353:355	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	46	dep	Background	150:159	arg1	1					147:147	1	147:147	1	147:147	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	46	dep	Background	150:159	arg1	considered					279:288	considered	279:288	are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS)	269:356	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	47	from	triggers	293:300	arg1	Syndrome					343:350	Irritable Bowel Syndrome	327:350	Irritable Bowel Syndrome (IBS)	327:356	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	47	from	triggers	293:300	arg1	IBS					353:355	IBS	353:355	IBS	353:355	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	10	48	theme	higher	1560:1565	arg1	severity					1567:1574	higher severity	1560:1574	higher severity	1560:1574	In IBS participants, higher severity was associated with lower intakes.
34960065	10	49	theme	lower	1596:1600	arg1	intakes					1602:1608	lower intakes	1596:1608	lower intakes	1596:1608	In IBS participants, higher severity was associated with lower intakes.
34960065	6	50	theme	±	1102:1102	arg1	g/day					1108:1112	19.4 ± 9.5 g/day	1097:1112	19.4 ± 9.5 g/day	1097:1112	FODMAPs accounted for a mean daily intake of 19.4 ± 9.5 g/day.
34960065	8	51	theme	%	1296:1296	arg1	p-value					1313:1319	p-value	1313:1319	p-value	1313:1319	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	8	51	theme	%	1296:1296	arg1	CI					1298:1299	95% CI	1294:1299	95% CI	1294:1299	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	2	52	theme	population-based	450:465	arg1	cohort					467:472	a large French population-based cohort	435:472	a large French population-based cohort	435:472	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	8	53	dep	CI	1298:1299	arg1	0.82-0.95					1302:1310	0.82-0.95	1302:1310	0.82-0.95	1302:1310	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	10	54	theme	IBS	1542:1544	arg1	participants					1546:1557	IBS participants	1542:1557	IBS participants	1542:1557	In IBS participants, higher severity was associated with lower intakes.
34960065	0	55	theme	Mono-Saccharides	29:44	arg1	Consumption					68:78	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption	0:78	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption	0:78	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption and Irritable Bowel Syndrome in the French NutriNet-Santé Cohort.
34960065	3	56	theme	24-h	686:689	arg1	recalls					691:697	three 24-h recalls	680:697	three 24-h recalls as well as anthropometrics	680:724	Among them, 27,949 eligible participants had previously completed three 24-h recalls as well as anthropometrics, socio-demographical and lifestyle data.
34960065	3	56	theme	24-h	686:689	arg1	data					761:764	socio-demographical and lifestyle data	727:764	socio-demographical and lifestyle data	727:764	Among them, 27,949 eligible participants had previously completed three 24-h recalls as well as anthropometrics, socio-demographical and lifestyle data.
34960065	0	57	theme	NutriNet-Santé	123:136	arg1	Cohort					138:143	the French NutriNet-Santé Cohort	112:143	the French NutriNet-Santé Cohort	112:143	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption and Irritable Bowel Syndrome in the French NutriNet-Santé Cohort.
34960065	2	58	theme	FODMAP	380:385	arg1	consumption					387:397	FODMAP consumption	380:397	FODMAP consumption in controls and IBS participants in a large French population-based cohort	380:472	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	2	59	from	IV	557:558	arg1	study					607:611	a cross sectional study	589:611	a cross sectional study	589:611	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	8	60	theme	non-IBS	1269:1275	arg1	ones					1277:1280	non-IBS ones	1269:1280	non-IBS ones	1269:1280	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	8	61	dep	aOR	1283:1285	arg1	0.88					1288:1291	0.88	1288:1291	0.88	1288:1291	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	8	61	dep	aOR	1283:1285	arg1	p-value					1313:1319	p-value	1313:1319	p-value	1313:1319	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	8	61	dep	aOR	1283:1285	arg1	CI					1298:1299	95% CI	1294:1299	95% CI	1294:1299	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	8	61	dep	aOR	1283:1285	arg1	0.001					1322:1326	0.001	1322:1326	0.001	1322:1326	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	4	62	theme	specific	819:826	arg1	table					840:844	a specific composition table	817:844	a specific composition table	817:844	Total FODMAP intake (in g/day) was computed using a specific composition table.
34960065	8	63	theme	95	1294:1295	arg1	%					1296:1296	%	1296:1296	%	1296:1296	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	5	64	theme	multivariable	909:921	arg1	models					943:948	multivariable logistic regression models	909:948	multivariable logistic regression models	909:948	The association between FODMAPs and IBS was estimated through multivariable logistic regression models; (3) Results: Included participants were mainly women (75.4%) and the mean age was 43.4 ± 14.1 years.
34960065	8	65	theme	lower	1239:1243	arg1	intakes					1245:1251	lower intakes	1239:1251	lower intakes in FODMAPs	1239:1262	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	2	66	from	questionnaire	572:584	arg1	study					607:611	a cross sectional study	589:611	a cross sectional study	589:611	Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study.
34960065	9	67	theme	IBS	1503:1505	arg1	participants					1507:1518	IBS participants	1503:1518	IBS participants	1503:1518	IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls.
34960065	5	68	theme	Included	964:971	arg1	participants					973:984	Included participants	964:984	Included participants	964:984	The association between FODMAPs and IBS was estimated through multivariable logistic regression models; (3) Results: Included participants were mainly women (75.4%) and the mean age was 43.4 ± 14.1 years.
34960065	5	69	theme	logistic	923:930	arg1	models					943:948	multivariable logistic regression models	909:948	multivariable logistic regression models	909:948	The association between FODMAPs and IBS was estimated through multivariable logistic regression models; (3) Results: Included participants were mainly women (75.4%) and the mean age was 43.4 ± 14.1 years.
34960065	7	70	theme	1295	1123:1126	arg1	participants					1128:1139	Overall 1295 participants	1115:1139	Overall 1295 participants (4.6%)	1115:1146	Overall 1295 participants (4.6%) were identified with an IBS.
34960065	7	70	theme	1295	1123:1126	arg1	%					1145:1145	4.6%	1142:1145	4.6%	1142:1145	Overall 1295 participants (4.6%) were identified with an IBS.
34960065	3	71	theme	socio-demographical	727:745	arg1	recalls					691:697	three 24-h recalls	680:697	three 24-h recalls as well as anthropometrics	680:724	Among them, 27,949 eligible participants had previously completed three 24-h recalls as well as anthropometrics, socio-demographical and lifestyle data.
34960065	3	71	theme	socio-demographical	727:745	arg1	data					761:764	socio-demographical and lifestyle data	727:764	socio-demographical and lifestyle data	727:764	Among them, 27,949 eligible participants had previously completed three 24-h recalls as well as anthropometrics, socio-demographical and lifestyle data.
34960065	0	72	from	Consumption	68:78	arg1	Cohort					138:143	the French NutriNet-Santé Cohort	112:143	the French NutriNet-Santé Cohort	112:143	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption and Irritable Bowel Syndrome in the French NutriNet-Santé Cohort.
34960065	5	73	theme	regression	932:941	arg1	models					943:948	multivariable logistic regression models	909:948	multivariable logistic regression models	909:948	The association between FODMAPs and IBS was estimated through multivariable logistic regression models; (3) Results: Included participants were mainly women (75.4%) and the mean age was 43.4 ± 14.1 years.
34960065	7	74	theme	Overall	1115:1121	arg1	participants					1128:1139	Overall 1295 participants	1115:1139	Overall 1295 participants (4.6%)	1115:1146	Overall 1295 participants (4.6%) were identified with an IBS.
34960065	7	74	theme	Overall	1115:1121	arg1	%					1145:1145	4.6%	1142:1145	4.6%	1142:1145	Overall 1295 participants (4.6%) were identified with an IBS.
34960065	8	75	contain	had	1235:1237	arg1	participants					1222:1233	IBS participants	1218:1233	IBS participants	1218:1233	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	8	75	contain	had	1235:1237	arg2	intakes					1245:1251	lower intakes	1239:1251	lower intakes in FODMAPs	1239:1262	After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82-0.95, p-value: 0.001).
34960065	5	76	theme	±	1038:1038	arg1	years					1045:1049	43.4 ± 14.1 years	1033:1049	43.4 ± 14.1 years	1033:1049	The association between FODMAPs and IBS was estimated through multivariable logistic regression models; (3) Results: Included participants were mainly women (75.4%) and the mean age was 43.4 ± 14.1 years.
34960065	0	77	from	Syndrome	100:107	arg1	Cohort					138:143	the French NutriNet-Santé Cohort	112:143	the French NutriNet-Santé Cohort	112:143	Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption and Irritable Bowel Syndrome in the French NutriNet-Santé Cohort.
34960065	1	78	from	symptoms	315:322	arg1	Syndrome					343:350	Irritable Bowel Syndrome	327:350	Irritable Bowel Syndrome (IBS)	327:356	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	78	from	symptoms	315:322	arg1	IBS					353:355	IBS	353:355	IBS	353:355	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	79	theme	fermentable	201:211	arg1	foods					171:175	Specific foods	162:175	Specific foods	162:175	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	79	theme	fermentable	201:211	arg1	triggers					293:300	triggers	293:300	triggers of digestive symptoms in Irritable Bowel Syndrome (IBS)	293:356	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	79	theme	fermentable	201:211	arg1	di-					221:223	di-	221:223	di-	221:223	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	79	theme	fermentable	201:211	arg1	mono-saccharides					230:245	mono-saccharides	230:245	mono-saccharides	230:245	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
34960065	1	79	theme	fermentable	201:211	arg1	oligo-					213:218	fermentable oligo-	201:218	fermentable oligo-	201:218	(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS).
35525751	8	0	theme	mineralized	1676:1686	arg1	material					1729:1736	This mineralized interpenetrating polymer network aerogel material	1671:1736	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance	1671:1777	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance shows potential for application in bone repair and regeneration.
35525751	2	1	theme	surface	384:390	arg1	roughness					392:400	possessing appropriate surface roughness	361:400	possessing appropriate surface roughness	361:400	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	2	theme	medical	630:636	arg1	translation					647:657	medical clinical translation	630:657	the development of these biomimetic materials in biosciences as well as medical clinical translation	558:657	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	6	3	dep	in	1539:1540	arg1	vitro					1542:1546	vitro	1542:1546	vitro	1542:1546	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	8	4	theme	polymer	1705:1711	arg1	material					1729:1736	This mineralized interpenetrating polymer network aerogel material	1671:1736	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance	1671:1777	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance shows potential for application in bone repair and regeneration.
35525751	1	5	theme	bone	287:290	arg1	engineering					299:309	bone tissue engineering	287:309	bone tissue engineering	287:309	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	3	6	theme	composite	756:764	arg1	material					782:789	network composite aerogel (M-S-C) material	748:789	network composite aerogel (M-S-C) material	748:789	In this work, a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material was prepared by freeze-drying using sol-gel and in situ mineralization strategy.
35525751	0	7	theme	Mineralized	0:10	arg1	silk					27:30	Mineralized self-assembled silk	0:30	Mineralized self-assembled silk	0:30	Mineralized self-assembled silk fibroin/cellulose interpenetrating network aerogel for bone tissue engineering.
35525751	4	8	theme	factors	896:902	arg1	property					1038:1045	the property	1034:1045	the property of M-S-C under defined conditions	1034:1079	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	4	8	theme	factors	896:902	arg1	effects					876:882	The effects	872:882	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process	872:1028	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	2	9	theme	materials	594:602	arg1	translation					647:657	medical clinical translation	630:657	the development of these biomimetic materials in biosciences as well as medical clinical translation	558:657	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	9	theme	materials	594:602	arg1	development					562:572	the development	558:572	the development of these biomimetic materials in biosciences as well as medical clinical translation	558:657	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	6	10	theme	cancellous	1384:1393	arg1	repair					1400:1405	an ideal cancellous bone repair	1375:1405	an ideal cancellous bone repair material	1375:1414	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	4	11	theme	change	965:970	arg1	properties					925:934	the surface properties	913:934	the surface properties of SF macromolecules and the change of mineralization time	913:993	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	1	12	from	field	278:282	arg1	engineering					299:309	bone tissue engineering	287:309	bone tissue engineering	287:309	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	4	13	from	effects	876:882	arg1	process					1022:1028	the n-HA self-assembly process	999:1028	the n-HA self-assembly process	999:1028	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	7	14	theme	kidney	1657:1662	arg1	cells					1664:1668	human embryonic kidney cells	1641:1668	human embryonic kidney cells	1641:1668	Moreover, M-S-C extracts can significantly accelerate the proliferation of human embryonic kidney cells.
35525751	4	15	theme	SF	939:940	arg1	macromolecules					942:955	SF macromolecules	939:955	SF macromolecules	939:955	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	7	16	theme	human	1641:1645	arg1	cells					1664:1668	human embryonic kidney cells	1641:1668	human embryonic kidney cells	1641:1668	Moreover, M-S-C extracts can significantly accelerate the proliferation of human embryonic kidney cells.
35525751	0	17	theme	bone	87:90	arg1	engineering					99:109	bone tissue engineering	87:109	bone tissue engineering	87:109	Mineralized self-assembled silk fibroin/cellulose interpenetrating network aerogel for bone tissue engineering.
35525751	4	18	theme	self-assembly	1008:1020	arg1	process					1022:1028	the n-HA self-assembly process	999:1028	the n-HA self-assembly process	999:1028	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	6	19	dep	repair	1400:1405	arg1	material					1407:1414	material	1407:1414	an ideal cancellous bone repair material	1375:1414	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	4	20	theme	mineralization	975:988	arg1	time					990:993	mineralization time	975:993	mineralization time	975:993	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	5	21	theme	tissue	1308:1313	arg1	engineering					1315:1325	bone tissue engineering	1303:1325	bone tissue engineering	1303:1325	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
35525751	4	22	theme	M-S-C	1050:1054	arg1	property					1038:1045	the property	1034:1045	the property of M-S-C under defined conditions	1034:1079	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	4	22	theme	M-S-C	1050:1054	arg1	effects					876:882	The effects	872:882	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process	872:1028	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	6	23	theme	adjustable	1474:1483	arg1	strength					1497:1504	moderately adjustable compressive strength	1463:1504	moderately adjustable compressive strength (12.7-22.4 MPa)	1463:1520	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	6	23	theme	adjustable	1474:1483	arg1	MPa					1517:1519	12.7-22.4 MPa	1507:1519	12.7-22.4 MPa	1507:1519	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	1	24	theme	tissue	292:297	arg1	engineering					299:309	bone tissue engineering	287:309	bone tissue engineering	287:309	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	6	25	dep	99.2	1432:1435	arg1	to					1429:1430	to	1429:1430	to	1429:1430	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	4	26	theme	defined	1062:1068	arg1	conditions					1070:1079	defined conditions	1062:1079	defined conditions	1062:1079	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	5	27	theme	in	1221:1222	arg1	cytotoxicity					1230:1241	in vitro cytotoxicity	1221:1241	in vitro cytotoxicity	1221:1241	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
35525751	1	28	theme	bioactive	131:139	arg1	materials					141:149	bioactive materials	131:149	bioactive materials with biomolecules as templates	131:180	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	3	29	theme	self-assembled	688:701	arg1	/cellulose					720:729	a mineralized self-assembled silk fibroin (SF)/cellulose	674:729	a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material	674:789	In this work, a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material was prepared by freeze-drying using sol-gel and in situ mineralization strategy.
35525751	2	30	theme	adequate	440:447	arg1	stability					429:437	structural stability	418:437	structural stability	418:437	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	30	theme	adequate	440:447	arg1	biodegradability					470:485	biodegradability	470:485	biodegradability	470:485	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	30	theme	adequate	440:447	arg1	biocompatibility					491:506	biocompatibility	491:506	biocompatibility	491:506	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	30	theme	adequate	440:447	arg1	issue					537:541	the core issue	528:541	the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation	528:657	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	30	theme	adequate	440:447	arg1	strength					460:467	adequate mechanical strength	440:467	adequate mechanical strength	440:467	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	30	theme	adequate	440:447	arg1	porosity					408:415	high porosity	403:415	high porosity	403:415	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	6	31	theme	thermal	1444:1450	arg1	stability					1452:1460	high thermal stability	1439:1460	high thermal stability	1439:1460	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	4	32	from	property	1038:1045	arg1	process					1022:1028	the n-HA self-assembly process	999:1028	the n-HA self-assembly process	999:1028	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	0	33	theme	interpenetrating	50:65	arg1	aerogel					75:81	interpenetrating network aerogel	50:81	interpenetrating network aerogel for bone tissue engineering	50:109	Mineralized self-assembled silk fibroin/cellulose interpenetrating network aerogel for bone tissue engineering.
35525751	5	34	theme	mechanical	1175:1184	arg1	property					1186:1193	mechanical property	1175:1193	mechanical property	1175:1193	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
35525751	1	35	dep	nucleation	197:206	arg1	the					193:195	the	193:195	the	193:195	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	2	36	theme	appropriate	372:382	arg1	roughness					392:400	possessing appropriate surface roughness	361:400	possessing appropriate surface roughness	361:400	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	3	37	theme	SF	717:718	arg1	/cellulose					720:729	a mineralized self-assembled silk fibroin (SF)/cellulose	674:729	a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material	674:789	In this work, a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material was prepared by freeze-drying using sol-gel and in situ mineralization strategy.
35525751	8	38	theme	network	1713:1719	arg1	material					1729:1736	This mineralized interpenetrating polymer network aerogel material	1671:1736	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance	1671:1777	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance shows potential for application in bone repair and regeneration.
35525751	1	39	theme	crystals	249:256	arg1	growth					212:217	growth	212:217	growth	212:217	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	1	39	theme	crystals	249:256	arg1	nucleation					197:206	nucleation	197:206	nucleation	197:206	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	3	40	theme	fibroin	708:714	arg1	/cellulose					720:729	a mineralized self-assembled silk fibroin (SF)/cellulose	674:729	a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material	674:789	In this work, a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material was prepared by freeze-drying using sol-gel and in situ mineralization strategy.
35525751	2	41	theme	high	403:406	arg1	stability					429:437	structural stability	418:437	structural stability	418:437	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	41	theme	high	403:406	arg1	biodegradability					470:485	biodegradability	470:485	biodegradability	470:485	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	41	theme	high	403:406	arg1	biocompatibility					491:506	biocompatibility	491:506	biocompatibility	491:506	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	41	theme	high	403:406	arg1	issue					537:541	the core issue	528:541	the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation	528:657	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	41	theme	high	403:406	arg1	strength					460:467	adequate mechanical strength	440:467	adequate mechanical strength	440:467	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	41	theme	high	403:406	arg1	porosity					408:415	high porosity	403:415	high porosity	403:415	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	3	42	theme	network	748:754	arg1	material					782:789	network composite aerogel (M-S-C) material	748:789	network composite aerogel (M-S-C) material	748:789	In this work, a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material was prepared by freeze-drying using sol-gel and in situ mineralization strategy.
35525751	2	43	theme	roughness	392:400	arg1	requirements					345:356	the performance requirements	329:356	the performance requirements of possessing appropriate surface roughness	329:400	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	8	44	theme	excellent	1743:1751	arg1	performance					1767:1777	excellent comprehensive performance	1743:1777	excellent comprehensive performance	1743:1777	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance shows potential for application in bone repair and regeneration.
35525751	1	45	theme	research	269:276	arg1	field					278:282	a vital research field	261:282	a vital research field in bone tissue engineering	261:309	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	1	45	theme	research	269:276	arg1	preparation					116:126	The preparation	112:126	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals	112:256	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	2	46	theme	clinical	638:645	arg1	translation					647:657	medical clinical translation	630:657	the development of these biomimetic materials in biosciences as well as medical clinical translation	558:657	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	8	47	theme	interpenetrating	1688:1703	arg1	material					1729:1736	This mineralized interpenetrating polymer network aerogel material	1671:1736	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance	1671:1777	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance shows potential for application in bone repair and regeneration.
35525751	3	48	theme	M-S-C	775:779	arg1	material					782:789	network composite aerogel (M-S-C) material	748:789	network composite aerogel (M-S-C) material	748:789	In this work, a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material was prepared by freeze-drying using sol-gel and in situ mineralization strategy.
35525751	3	49	theme	aerogel	766:772	arg1	material					782:789	network composite aerogel (M-S-C) material	748:789	network composite aerogel (M-S-C) material	748:789	In this work, a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material was prepared by freeze-drying using sol-gel and in situ mineralization strategy.
35525751	2	50	theme	performance	333:343	arg1	requirements					345:356	the performance requirements	329:356	the performance requirements of possessing appropriate surface roughness	329:400	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	4	51	theme	main	891:894	arg1	factors					896:902	the main factors	887:902	the main factors	887:902	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	4	51	theme	main	891:894	arg1	properties					925:934	the surface properties	913:934	the surface properties of SF macromolecules and the change of mineralization time	913:993	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	6	52	theme	bone	1395:1398	arg1	repair					1400:1405	an ideal cancellous bone repair	1375:1405	an ideal cancellous bone repair material	1375:1414	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	6	53	theme	degradation	1548:1558	arg1	rate					1560:1563	appreciable in vitro degradation rate	1527:1563	appreciable in vitro degradation rate	1527:1563	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	1	54	theme	nano-hydroxyapatite	222:240	arg1	crystals					249:256	nano-hydroxyapatite (n-HA) crystals	222:256	nano-hydroxyapatite (n-HA) crystals	222:256	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	4	55	theme	macromolecules	942:955	arg1	properties					925:934	the surface properties	913:934	the surface properties of SF macromolecules and the change of mineralization time	913:993	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	6	56	theme	ideal	1378:1382	arg1	repair					1400:1405	an ideal cancellous bone repair	1375:1405	an ideal cancellous bone repair material	1375:1414	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	3	57	dep	in	839:840	arg1	situ					842:845	situ	842:845	situ	842:845	In this work, a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material was prepared by freeze-drying using sol-gel and in situ mineralization strategy.
35525751	6	58	theme	in	1539:1540	arg1	rate					1560:1563	appreciable in vitro degradation rate	1527:1563	appreciable in vitro degradation rate	1527:1563	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	1	59	theme	n-HA	243:246	arg1	crystals					249:256	nano-hydroxyapatite (n-HA) crystals	222:256	nano-hydroxyapatite (n-HA) crystals	222:256	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	8	60	theme	aerogel	1721:1727	arg1	material					1729:1736	This mineralized interpenetrating polymer network aerogel material	1671:1736	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance	1671:1777	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance shows potential for application in bone repair and regeneration.
35525751	7	61	theme	cells	1664:1668	arg1	proliferation					1624:1636	the proliferation	1620:1636	the proliferation of human embryonic kidney cells	1620:1668	Moreover, M-S-C extracts can significantly accelerate the proliferation of human embryonic kidney cells.
35525751	3	62	theme	sol-gel	827:833	arg1	strategy					862:869	sol-gel and in situ mineralization strategy	827:869	strategy	862:869	In this work, a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material was prepared by freeze-drying using sol-gel and in situ mineralization strategy.
35525751	5	63	theme	M-S-C	1114:1118	arg1	morphology					1163:1172	morphology	1163:1172	morphology	1163:1172	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
35525751	5	63	theme	M-S-C	1114:1118	arg1	behavior					1208:1215	degradation behavior	1196:1215	degradation behavior	1196:1215	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
35525751	5	63	theme	M-S-C	1114:1118	arg1	property					1186:1193	mechanical property	1175:1193	mechanical property	1175:1193	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
35525751	5	63	theme	M-S-C	1114:1118	arg1	properties					1100:1109	The properties	1096:1109	The properties	1096:1109	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
35525751	5	63	theme	M-S-C	1114:1118	arg1	cytotoxicity					1230:1241	in vitro cytotoxicity	1221:1241	in vitro cytotoxicity	1221:1241	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
35525751	5	63	theme	M-S-C	1114:1118	arg1	properties					1151:1160	the physicochemical properties	1131:1160	the physicochemical properties	1131:1160	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
35525751	1	64	theme	materials	141:149	arg1	preparation					116:126	The preparation	112:126	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals	112:256	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	1	64	theme	materials	141:149	arg1	field					278:282	a vital research field	261:282	a vital research field in bone tissue engineering	261:309	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	7	65	theme	embryonic	1647:1655	arg1	cells					1664:1668	human embryonic kidney cells	1641:1668	human embryonic kidney cells	1641:1668	Moreover, M-S-C extracts can significantly accelerate the proliferation of human embryonic kidney cells.
35525751	4	66	theme	surface	917:923	arg1	properties					925:934	the surface properties	913:934	the surface properties of SF macromolecules and the change of mineralization time	913:993	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	2	67	from	development	562:572	arg1	biosciences					607:617	biosciences	607:617	biosciences	607:617	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	8	68	theme	bone	1814:1817	arg1	repair					1819:1824	bone repair	1814:1824	bone repair	1814:1824	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance shows potential for application in bone repair and regeneration.
35525751	3	69	theme	mineralization	847:860	arg1	strategy					862:869	sol-gel and in situ mineralization strategy	827:869	strategy	862:869	In this work, a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material was prepared by freeze-drying using sol-gel and in situ mineralization strategy.
35525751	0	70	theme	tissue	92:97	arg1	engineering					99:109	bone tissue engineering	87:109	bone tissue engineering	87:109	Mineralized self-assembled silk fibroin/cellulose interpenetrating network aerogel for bone tissue engineering.
35525751	2	71	theme	core	532:535	arg1	stability					429:437	structural stability	418:437	structural stability	418:437	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	71	theme	core	532:535	arg1	biodegradability					470:485	biodegradability	470:485	biodegradability	470:485	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	71	theme	core	532:535	arg1	biocompatibility					491:506	biocompatibility	491:506	biocompatibility	491:506	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	71	theme	core	532:535	arg1	issue					537:541	the core issue	528:541	the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation	528:657	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	71	theme	core	532:535	arg1	strength					460:467	adequate mechanical strength	440:467	adequate mechanical strength	440:467	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	71	theme	core	532:535	arg1	porosity					408:415	high porosity	403:415	high porosity	403:415	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	5	72	dep	in	1221:1222	arg1	vitro					1224:1228	vitro	1224:1228	vitro	1224:1228	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
35525751	3	73	theme	in	839:840	arg1	strategy					862:869	sol-gel and in situ mineralization strategy	827:869	strategy	862:869	In this work, a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material was prepared by freeze-drying using sol-gel and in situ mineralization strategy.
35525751	4	74	theme	n-HA	1003:1006	arg1	process					1022:1028	the n-HA self-assembly process	999:1028	the n-HA self-assembly process	999:1028	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	5	75	theme	bone	1303:1306	arg1	engineering					1315:1325	bone tissue engineering	1303:1325	bone tissue engineering	1303:1325	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
35525751	6	76	dep	porosity	1417:1424	arg1	%					1436:1436	up to 99.2%	1426:1436	porosity up to 99.2%	1417:1436	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	2	77	theme	biomimetic	583:592	arg1	materials					594:602	these biomimetic materials	577:602	these biomimetic materials	577:602	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	4	78	theme	time	990:993	arg1	macromolecules					942:955	SF macromolecules	939:955	SF macromolecules	939:955	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	4	78	theme	time	990:993	arg1	change					965:970	the change	961:970	the change of mineralization time	961:993	The effects of the main factors, such as the surface properties of SF macromolecules and the change of mineralization time, on the n-HA self-assembly process and the property of M-S-C under defined conditions were explored.
35525751	2	79	from	time	520:523	arg1	stability					429:437	structural stability	418:437	structural stability	418:437	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	79	from	time	520:523	arg1	biodegradability					470:485	biodegradability	470:485	biodegradability	470:485	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	79	from	time	520:523	arg1	biocompatibility					491:506	biocompatibility	491:506	biocompatibility	491:506	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	79	from	time	520:523	arg1	issue					537:541	the core issue	528:541	the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation	528:657	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	79	from	time	520:523	arg1	strength					460:467	adequate mechanical strength	440:467	adequate mechanical strength	440:467	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	79	from	time	520:523	arg1	porosity					408:415	high porosity	403:415	high porosity	403:415	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	80	theme	structural	418:427	arg1	stability					429:437	structural stability	418:437	structural stability	418:437	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	80	theme	structural	418:427	arg1	biodegradability					470:485	biodegradability	470:485	biodegradability	470:485	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	80	theme	structural	418:427	arg1	biocompatibility					491:506	biocompatibility	491:506	biocompatibility	491:506	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	80	theme	structural	418:427	arg1	issue					537:541	the core issue	528:541	the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation	528:657	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	80	theme	structural	418:427	arg1	strength					460:467	adequate mechanical strength	440:467	adequate mechanical strength	440:467	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	80	theme	structural	418:427	arg1	porosity					408:415	high porosity	403:415	high porosity	403:415	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	0	81	theme	self-assembled	12:25	arg1	silk					27:30	Mineralized self-assembled silk	0:30	Mineralized self-assembled silk	0:30	Mineralized self-assembled silk fibroin/cellulose interpenetrating network aerogel for bone tissue engineering.
35525751	5	82	theme	physicochemical	1135:1149	arg1	properties					1151:1160	the physicochemical properties	1131:1160	the physicochemical properties	1131:1160	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
35525751	1	83	with	materials	141:149	arg1	biomolecules					156:167	biomolecules	156:167	biomolecules as templates	156:180	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	2	84	from	translation	647:657	arg1	biosciences					607:617	biosciences	607:617	biosciences	607:617	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	8	85	with	material	1729:1736	arg1	performance					1767:1777	excellent comprehensive performance	1743:1777	excellent comprehensive performance	1743:1777	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance shows potential for application in bone repair and regeneration.
35525751	3	86	theme	mineralized	676:686	arg1	/cellulose					720:729	a mineralized self-assembled silk fibroin (SF)/cellulose	674:729	a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material	674:789	In this work, a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material was prepared by freeze-drying using sol-gel and in situ mineralization strategy.
35525751	2	87	theme	mechanical	449:458	arg1	stability					429:437	structural stability	418:437	structural stability	418:437	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	87	theme	mechanical	449:458	arg1	biodegradability					470:485	biodegradability	470:485	biodegradability	470:485	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	87	theme	mechanical	449:458	arg1	biocompatibility					491:506	biocompatibility	491:506	biocompatibility	491:506	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	87	theme	mechanical	449:458	arg1	issue					537:541	the core issue	528:541	the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation	528:657	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	87	theme	mechanical	449:458	arg1	strength					460:467	adequate mechanical strength	440:467	adequate mechanical strength	440:467	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	2	87	theme	mechanical	449:458	arg1	porosity					408:415	high porosity	403:415	high porosity	403:415	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	0	88	theme	network	67:73	arg1	aerogel					75:81	interpenetrating network aerogel	50:81	interpenetrating network aerogel for bone tissue engineering	50:109	Mineralized self-assembled silk fibroin/cellulose interpenetrating network aerogel for bone tissue engineering.
35525751	7	89	theme	M-S-C	1576:1580	arg1	extracts					1582:1589	M-S-C extracts	1576:1589	M-S-C extracts	1576:1589	Moreover, M-S-C extracts can significantly accelerate the proliferation of human embryonic kidney cells.
35525751	2	90	theme	same	515:518	arg1	time					520:523	the same time	511:523	the same time	511:523	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	8	91	from	application	1799:1809	arg1	repair					1819:1824	bone repair	1814:1824	bone repair	1814:1824	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance shows potential for application in bone repair and regeneration.
35525751	8	91	from	application	1799:1809	arg1	regeneration					1830:1841	regeneration	1830:1841	regeneration	1830:1841	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance shows potential for application in bone repair and regeneration.
35525751	6	92	theme	high	1439:1442	arg1	stability					1452:1460	high thermal stability	1439:1460	high thermal stability	1439:1460	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	2	93	theme	possessing	361:370	arg1	roughness					392:400	possessing appropriate surface roughness	361:400	possessing appropriate surface roughness	361:400	However, meeting the performance requirements of possessing appropriate surface roughness, high porosity, structural stability, adequate mechanical strength, biodegradability and biocompatibility at the same time is the core issue that restricts the development of these biomimetic materials in biosciences as well as medical clinical translation.
35525751	6	94	theme	appreciable	1527:1537	arg1	rate					1560:1563	appreciable in vitro degradation rate	1527:1563	appreciable in vitro degradation rate	1527:1563	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	5	95	theme	degradation	1196:1206	arg1	behavior					1208:1215	degradation behavior	1196:1215	degradation behavior	1196:1215	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
35525751	3	96	theme	silk	703:706	arg1	/cellulose					720:729	a mineralized self-assembled silk fibroin (SF)/cellulose	674:729	a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material	674:789	In this work, a mineralized self-assembled silk fibroin (SF)/cellulose interpenetrating network composite aerogel (M-S-C) material was prepared by freeze-drying using sol-gel and in situ mineralization strategy.
35525751	1	97	theme	vital	263:267	arg1	field					278:282	a vital research field	261:282	a vital research field in bone tissue engineering	261:309	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	1	97	theme	vital	263:267	arg1	preparation					116:126	The preparation	112:126	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals	112:256	The preparation of bioactive materials with biomolecules as templates to control the nucleation and growth of nano-hydroxyapatite (n-HA) crystals is a vital research field in bone tissue engineering.
35525751	6	98	theme	compressive	1485:1495	arg1	strength					1497:1504	moderately adjustable compressive strength	1463:1504	moderately adjustable compressive strength (12.7-22.4 MPa)	1463:1520	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	6	98	theme	compressive	1485:1495	arg1	MPa					1517:1519	12.7-22.4 MPa	1507:1519	12.7-22.4 MPa	1507:1519	M-S-C exhibits the microstructure required for an ideal cancellous bone repair material, porosity up to 99.2%, high thermal stability, moderately adjustable compressive strength (12.7-22.4 MPa), and appreciable in vitro degradation rate.
35525751	8	99	theme	comprehensive	1753:1765	arg1	performance					1767:1777	excellent comprehensive performance	1743:1777	excellent comprehensive performance	1743:1777	This mineralized interpenetrating polymer network aerogel material with excellent comprehensive performance shows potential for application in bone repair and regeneration.
35525751	5	100	theme	application	1278:1288	arg1	prospects					1290:1298	its application prospects	1274:1298	its application prospects	1274:1298	The properties of M-S-C, including the physicochemical properties, morphology, mechanical property, degradation behavior and in vitro cytotoxicity, were investigated to evaluate its application prospects in bone tissue engineering.
34742443	0	0	theme	self-powered	102:113	arg1	sensing					115:121	self-powered sensing	102:121	self-powered sensing	102:121	Flexible layered cotton cellulose-based nanofibrous membranes for piezoelectric energy harvesting and self-powered sensing.
34742443	3	1	theme	robust	381:386	arg1	membranes					405:413	robust, durable layered membranes	381:413	robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	381:525	Therefore, we demonstrate the development of piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers.
34742443	8	2	theme	cellulose-based	1197:1211	arg1	membranes					1213:1221	Such cellulose-based membranes	1192:1221	Such cellulose-based membranes	1192:1221	Such cellulose-based membranes can be up-scaled to fabricate ecofriendly, flexible and durable energy harvesters and self-powered wearable sensors.
34742443	7	3	theme	human	1144:1148	arg1	motions					1164:1170	human physiological motions	1144:1170	human physiological motions	1144:1170	The self-powered device could also be used to detect human physiological motions in different forms.
34742443	1	4	theme	energy	190:195	arg1	harvesting					197:206	piezoelectric energy harvesting	176:206	piezoelectric energy harvesting	176:206	Cellulose has attracted an increasing attention for piezoelectric energy harvesting.
34742443	8	5	theme	energy	1287:1292	arg1	harvesters					1294:1303	ecofriendly, flexible and durable energy harvesters	1253:1303	ecofriendly, flexible and durable energy harvesters	1253:1303	Such cellulose-based membranes can be up-scaled to fabricate ecofriendly, flexible and durable energy harvesters and self-powered wearable sensors.
34742443	4	6	theme	layer-layer	614:624	arg1	interfaces					626:635	interlocked layer-layer interfaces	602:635	interlocked layer-layer interfaces that covalently bind component layers	602:673	Exploiting polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges, interlocked layer-layer interfaces that covalently bind component layers are constructed by a facile and scalable approach.
34742443	8	7	theme	Such	1192:1195	arg1	membranes					1213:1221	Such cellulose-based membranes	1192:1221	Such cellulose-based membranes	1192:1221	Such cellulose-based membranes can be up-scaled to fabricate ecofriendly, flexible and durable energy harvesters and self-powered wearable sensors.
34742443	5	8	theme	maximum	803:809	arg1	coefficient					825:835	a maximum piezoelectric coefficient	801:835	a maximum piezoelectric coefficient of 27.2 pC/N	801:848	As-obtained membranes exhibit significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N, power density of 1.72 μW/cm2, and stability over 8000 cycles.
34742443	4	9	theme	interlocked	602:612	arg1	interfaces					626:635	interlocked layer-layer interfaces	602:635	interlocked layer-layer interfaces that covalently bind component layers	602:673	Exploiting polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges, interlocked layer-layer interfaces that covalently bind component layers are constructed by a facile and scalable approach.
34742443	3	10	theme	cotton	427:432	arg1	nanofibers					516:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	Therefore, we demonstrate the development of piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers.
34742443	3	11	theme	layered	397:403	arg1	membranes					405:413	robust, durable layered membranes	381:413	robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	381:525	Therefore, we demonstrate the development of piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers.
34742443	6	12	theme	pristine	962:969	arg1	cellulose					971:979	pristine cellulose	962:979	pristine cellulose	962:979	Substantial enhancement in piezoelectricity over pristine cellulose is ascribed to the synergy of components and the localized stress concentration induced by pBT nanoparticles.
34742443	5	13	with	piezoelectricity	779:794	arg1	coefficient					825:835	a maximum piezoelectric coefficient	801:835	a maximum piezoelectric coefficient of 27.2 pC/N	801:848	As-obtained membranes exhibit significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N, power density of 1.72 μW/cm2, and stability over 8000 cycles.
34742443	4	14	theme	facile	696:701	arg1	approach					716:723	a facile and scalable approach	694:723	a facile and scalable approach	694:723	Exploiting polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges, interlocked layer-layer interfaces that covalently bind component layers are constructed by a facile and scalable approach.
34742443	6	15	theme	concentration	1047:1059	arg1	synergy					1000:1006	the synergy	996:1006	the synergy of components and the localized stress concentration induced by pBT nanoparticles	996:1088	Substantial enhancement in piezoelectricity over pristine cellulose is ascribed to the synergy of components and the localized stress concentration induced by pBT nanoparticles.
34742443	5	16	theme	As-obtained	726:736	arg1	membranes					738:746	As-obtained membranes	726:746	As-obtained membranes	726:746	As-obtained membranes exhibit significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N, power density of 1.72 μW/cm2, and stability over 8000 cycles.
34742443	4	17	theme	interlayer	582:591	arg1	bridges					593:599	interlayer bridges	582:599	interlayer bridges	582:599	Exploiting polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges, interlocked layer-layer interfaces that covalently bind component layers are constructed by a facile and scalable approach.
34742443	0	18	theme	Flexible	0:7	arg1	membranes					52:60	Flexible layered cotton cellulose-based nanofibrous membranes	0:60	Flexible layered cotton cellulose-based nanofibrous membranes for piezoelectric energy harvesting and self-powered sensing	0:121	Flexible layered cotton cellulose-based nanofibrous membranes for piezoelectric energy harvesting and self-powered sensing.
34742443	0	19	theme	layered	9:15	arg1	membranes					52:60	Flexible layered cotton cellulose-based nanofibrous membranes	0:60	Flexible layered cotton cellulose-based nanofibrous membranes for piezoelectric energy harvesting and self-powered sensing	0:121	Flexible layered cotton cellulose-based nanofibrous membranes for piezoelectric energy harvesting and self-powered sensing.
34742443	6	20	theme	localized	1030:1038	arg1	concentration					1047:1059	the localized stress concentration	1026:1059	the localized stress concentration induced by pBT nanoparticles	1026:1088	Substantial enhancement in piezoelectricity over pristine cellulose is ascribed to the synergy of components and the localized stress concentration induced by pBT nanoparticles.
34742443	6	21	theme	pBT	1072:1074	arg1	nanoparticles					1076:1088	pBT nanoparticles	1072:1088	pBT nanoparticles	1072:1088	Substantial enhancement in piezoelectricity over pristine cellulose is ascribed to the synergy of components and the localized stress concentration induced by pBT nanoparticles.
34742443	7	22	used	used	1129:1132	arg2	device					1108:1113	The self-powered device	1091:1113	The self-powered device	1091:1113	The self-powered device could also be used to detect human physiological motions in different forms.
34742443	3	23	theme	polyvinylidene	480:493	arg1	nanofibers					516:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	Therefore, we demonstrate the development of piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers.
34742443	8	24	theme	durable	1279:1285	arg1	harvesters					1294:1303	ecofriendly, flexible and durable energy harvesters	1253:1303	ecofriendly, flexible and durable energy harvesters	1253:1303	Such cellulose-based membranes can be up-scaled to fabricate ecofriendly, flexible and durable energy harvesters and self-powered wearable sensors.
34742443	5	25	theme	improved	770:777	arg1	piezoelectricity					779:794	significantly improved piezoelectricity	756:794	significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N	756:848	As-obtained membranes exhibit significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N, power density of 1.72 μW/cm2, and stability over 8000 cycles.
34742443	3	26	theme	cellulose	434:442	arg1	nanofibers					516:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	Therefore, we demonstrate the development of piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers.
34742443	4	27	theme	component	658:666	arg1	layers					668:673	component layers	658:673	component layers	658:673	Exploiting polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges, interlocked layer-layer interfaces that covalently bind component layers are constructed by a facile and scalable approach.
34742443	3	28	dep	robust	381:386	arg1	durable					389:395	durable	389:395	durable	389:395	Therefore, we demonstrate the development of piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers.
34742443	6	29	theme	Substantial	913:923	arg1	enhancement					925:935	Substantial enhancement	913:935	Substantial enhancement in piezoelectricity over pristine cellulose	913:979	Substantial enhancement in piezoelectricity over pristine cellulose is ascribed to the synergy of components and the localized stress concentration induced by pBT nanoparticles.
34742443	6	30	from	enhancement	925:935	arg1	piezoelectricity					940:955	piezoelectricity	940:955	piezoelectricity	940:955	Substantial enhancement in piezoelectricity over pristine cellulose is ascribed to the synergy of components and the localized stress concentration induced by pBT nanoparticles.
34742443	0	31	theme	cotton	17:22	arg1	membranes					52:60	Flexible layered cotton cellulose-based nanofibrous membranes	0:60	Flexible layered cotton cellulose-based nanofibrous membranes for piezoelectric energy harvesting and self-powered sensing	0:121	Flexible layered cotton cellulose-based nanofibrous membranes for piezoelectric energy harvesting and self-powered sensing.
34742443	8	32	theme	ecofriendly	1253:1263	arg1	harvesters					1294:1303	ecofriendly, flexible and durable energy harvesters	1253:1303	ecofriendly, flexible and durable energy harvesters	1253:1303	Such cellulose-based membranes can be up-scaled to fabricate ecofriendly, flexible and durable energy harvesters and self-powered wearable sensors.
34742443	4	33	theme	BaTiO3	552:557	arg1	nanoparticles					565:577	polydopamine@BaTiO3 (pBT) nanoparticles	539:577	polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges	539:599	Exploiting polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges, interlocked layer-layer interfaces that covalently bind component layers are constructed by a facile and scalable approach.
34742443	5	34	with	density	857:863	arg1	coefficient					825:835	a maximum piezoelectric coefficient	801:835	a maximum piezoelectric coefficient of 27.2 pC/N	801:848	As-obtained membranes exhibit significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N, power density of 1.72 μW/cm2, and stability over 8000 cycles.
34742443	3	35	theme	PVDF-g-MA	505:513	arg1	nanofibers					516:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	Therefore, we demonstrate the development of piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers.
34742443	5	36	theme	power	851:855	arg1	density					857:863	power density	851:863	power density of 1.72 μW/cm2	851:878	As-obtained membranes exhibit significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N, power density of 1.72 μW/cm2, and stability over 8000 cycles.
34742443	4	37	theme	@	551:551	arg1	BaTiO3					552:557	polydopamine@BaTiO3	539:557	polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges	539:599	Exploiting polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges, interlocked layer-layer interfaces that covalently bind component layers are constructed by a facile and scalable approach.
34742443	4	37	theme	@	551:551	arg1	pBT					560:562	pBT	560:562	pBT	560:562	Exploiting polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges, interlocked layer-layer interfaces that covalently bind component layers are constructed by a facile and scalable approach.
34742443	2	38	dep	applications	284:295	arg1	piezoelectricity					230:245	the limited piezoelectricity	218:245	the limited piezoelectricity of natural cellulose constraints	218:278	However, the limited piezoelectricity of natural cellulose constraints the applications.
34742443	0	39	theme	nanofibrous	40:50	arg1	membranes					52:60	Flexible layered cotton cellulose-based nanofibrous membranes	0:60	Flexible layered cotton cellulose-based nanofibrous membranes for piezoelectric energy harvesting and self-powered sensing	0:121	Flexible layered cotton cellulose-based nanofibrous membranes for piezoelectric energy harvesting and self-powered sensing.
34742443	8	40	theme	flexible	1266:1273	arg1	harvesters					1294:1303	ecofriendly, flexible and durable energy harvesters	1253:1303	ecofriendly, flexible and durable energy harvesters	1253:1303	Such cellulose-based membranes can be up-scaled to fabricate ecofriendly, flexible and durable energy harvesters and self-powered wearable sensors.
34742443	6	41	theme	components	1011:1020	arg1	synergy					1000:1006	the synergy	996:1006	the synergy of components and the localized stress concentration induced by pBT nanoparticles	996:1088	Substantial enhancement in piezoelectricity over pristine cellulose is ascribed to the synergy of components and the localized stress concentration induced by pBT nanoparticles.
34742443	0	42	theme	cellulose-based	24:38	arg1	membranes					52:60	Flexible layered cotton cellulose-based nanofibrous membranes	0:60	Flexible layered cotton cellulose-based nanofibrous membranes for piezoelectric energy harvesting and self-powered sensing	0:121	Flexible layered cotton cellulose-based nanofibrous membranes for piezoelectric energy harvesting and self-powered sensing.
34742443	3	43	theme	fluoride	495:502	arg1	nanofibers					516:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	Therefore, we demonstrate the development of piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers.
34742443	5	44	theme	piezoelectric	811:823	arg1	coefficient					825:835	a maximum piezoelectric coefficient	801:835	a maximum piezoelectric coefficient of 27.2 pC/N	801:848	As-obtained membranes exhibit significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N, power density of 1.72 μW/cm2, and stability over 8000 cycles.
34742443	0	45	theme	energy	80:85	arg1	harvesting					87:96	piezoelectric energy harvesting	66:96	piezoelectric energy harvesting	66:96	Flexible layered cotton cellulose-based nanofibrous membranes for piezoelectric energy harvesting and self-powered sensing.
34742443	2	46	theme	constraints	268:278	arg1	piezoelectricity					230:245	the limited piezoelectricity	218:245	the limited piezoelectricity of natural cellulose constraints	218:278	However, the limited piezoelectricity of natural cellulose constraints the applications.
34742443	6	47	theme	stress	1040:1045	arg1	concentration					1047:1059	the localized stress concentration	1026:1059	the localized stress concentration induced by pBT nanoparticles	1026:1088	Substantial enhancement in piezoelectricity over pristine cellulose is ascribed to the synergy of components and the localized stress concentration induced by pBT nanoparticles.
34742443	5	48	theme	pC/N	845:848	arg1	coefficient					825:835	a maximum piezoelectric coefficient	801:835	a maximum piezoelectric coefficient of 27.2 pC/N	801:848	As-obtained membranes exhibit significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N, power density of 1.72 μW/cm2, and stability over 8000 cycles.
34742443	2	49	theme	natural	250:256	arg1	constraints					268:278	natural cellulose constraints	250:278	natural cellulose constraints	250:278	However, the limited piezoelectricity of natural cellulose constraints the applications.
34742443	2	50	theme	cellulose	258:266	arg1	constraints					268:278	natural cellulose constraints	250:278	natural cellulose constraints	250:278	However, the limited piezoelectricity of natural cellulose constraints the applications.
34742443	7	51	theme	self-powered	1095:1106	arg1	device					1108:1113	The self-powered device	1091:1113	The self-powered device	1091:1113	The self-powered device could also be used to detect human physiological motions in different forms.
34742443	3	52	theme	piezoelectric	343:355	arg1	nanogenerators					357:370	piezoelectric nanogenerators	343:370	piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	343:525	Therefore, we demonstrate the development of piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers.
34742443	7	53	theme	different	1175:1183	arg1	forms					1185:1189	different forms	1175:1189	different forms	1175:1189	The self-powered device could also be used to detect human physiological motions in different forms.
34742443	1	54	theme	increasing	151:160	arg1	attention					162:170	an increasing attention	148:170	an increasing attention	148:170	Cellulose has attracted an increasing attention for piezoelectric energy harvesting.
34742443	3	55	theme	nanogenerators	357:370	arg1	development					328:338	the development	324:338	the development of piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	324:525	Therefore, we demonstrate the development of piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers.
34742443	4	56	theme	polydopamine	539:550	arg1	BaTiO3					552:557	polydopamine@BaTiO3	539:557	polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges	539:599	Exploiting polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges, interlocked layer-layer interfaces that covalently bind component layers are constructed by a facile and scalable approach.
34742443	4	56	theme	polydopamine	539:550	arg1	pBT					560:562	pBT	560:562	pBT	560:562	Exploiting polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges, interlocked layer-layer interfaces that covalently bind component layers are constructed by a facile and scalable approach.
34742443	7	57	theme	physiological	1150:1162	arg1	motions					1164:1170	human physiological motions	1144:1170	human physiological motions	1144:1170	The self-powered device could also be used to detect human physiological motions in different forms.
34742443	8	58	theme	self-powered	1309:1320	arg1	sensors					1331:1337	self-powered wearable sensors	1309:1337	self-powered wearable sensors	1309:1337	Such cellulose-based membranes can be up-scaled to fabricate ecofriendly, flexible and durable energy harvesters and self-powered wearable sensors.
34742443	4	59	theme	scalable	707:714	arg1	approach					716:723	a facile and scalable approach	694:723	a facile and scalable approach	694:723	Exploiting polydopamine@BaTiO3 (pBT) nanoparticles as interlayer bridges, interlocked layer-layer interfaces that covalently bind component layers are constructed by a facile and scalable approach.
34742443	8	60	theme	wearable	1322:1329	arg1	sensors					1331:1337	self-powered wearable sensors	1309:1337	self-powered wearable sensors	1309:1337	Such cellulose-based membranes can be up-scaled to fabricate ecofriendly, flexible and durable energy harvesters and self-powered wearable sensors.
34742443	2	61	theme	limited	222:228	arg1	piezoelectricity					230:245	the limited piezoelectricity	218:245	the limited piezoelectricity of natural cellulose constraints	218:278	However, the limited piezoelectricity of natural cellulose constraints the applications.
34742443	5	62	with	stability	885:893	arg1	coefficient					825:835	a maximum piezoelectric coefficient	801:835	a maximum piezoelectric coefficient of 27.2 pC/N	801:848	As-obtained membranes exhibit significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N, power density of 1.72 μW/cm2, and stability over 8000 cycles.
34742443	3	63	theme	maleic-anhydride-grafted	455:478	arg1	nanofibers					516:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	Therefore, we demonstrate the development of piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers.
34742443	0	64	theme	piezoelectric	66:78	arg1	harvesting					87:96	piezoelectric energy harvesting	66:96	piezoelectric energy harvesting	66:96	Flexible layered cotton cellulose-based nanofibrous membranes for piezoelectric energy harvesting and self-powered sensing.
34742443	3	65	theme	interfaced	444:453	arg1	nanofibers					516:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers	427:525	Therefore, we demonstrate the development of piezoelectric nanogenerators based on robust, durable layered membranes composed of cotton cellulose interfaced maleic-anhydride-grafted polyvinylidene fluoride (PVDF-g-MA) nanofibers.
34742443	1	66	theme	piezoelectric	176:188	arg1	harvesting					197:206	piezoelectric energy harvesting	176:206	piezoelectric energy harvesting	176:206	Cellulose has attracted an increasing attention for piezoelectric energy harvesting.
34742443	5	67	theme	1.72 μW/cm2	868:878	arg1	stability					885:893	stability	885:893	stability over 8000 cycles	885:910	As-obtained membranes exhibit significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N, power density of 1.72 μW/cm2, and stability over 8000 cycles.
34742443	5	67	theme	1.72 μW/cm2	868:878	arg1	piezoelectricity					779:794	significantly improved piezoelectricity	756:794	significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N	756:848	As-obtained membranes exhibit significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N, power density of 1.72 μW/cm2, and stability over 8000 cycles.
34742443	5	67	theme	1.72 μW/cm2	868:878	arg1	density					857:863	power density	851:863	power density of 1.72 μW/cm2	851:878	As-obtained membranes exhibit significantly improved piezoelectricity with a maximum piezoelectric coefficient of 27.2 pC/N, power density of 1.72 μW/cm2, and stability over 8000 cycles.
33610605	6	0	theme	deviation	855:863	arg1	recoveries					786:795	high recoveries	781:795	high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%)	781:877	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	2	1	theme	solid-state	326:336	arg1	NMR					342:344	solid-state 13C NMR	326:344	solid-state 13C NMR	326:344	The products were characterized by FTIR, TG, DSC, UV-Vis, XRD, solid-state 13C NMR, and SEM.
33610605	6	2	theme	real	920:923	arg1	samples					925:931	real samples	920:931	real samples	920:931	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	5	3	theme	dual-site	731:739	arg1	model					761:765	the dual-site Langmuir-Freundlich model	727:765	the dual-site Langmuir-Freundlich model	727:765	The adsorption isotherms of [KGM + DB18C6] on Cu2+ followed the dual-site Langmuir-Freundlich model.
33610605	6	4	theme	standard	846:853	arg1	deviation					855:863	low relative standard deviation	833:863	low relative standard deviation (below 5.00%)	833:877	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	4	5	theme	kinetic	652:658	arg1	model					660:664	the pseudo-second-order kinetic model	628:664	the pseudo-second-order kinetic model	628:664	The adsorption kinetics of [KGM + DB18C6] on Cu2+ could be described by the pseudo-second-order kinetic model.
33610605	5	6	from	isotherms	682:690	arg1	Cu2+					713:716	Cu2+	713:716	Cu2+	713:716	The adsorption isotherms of [KGM + DB18C6] on Cu2+ followed the dual-site Langmuir-Freundlich model.
33610605	6	7	theme	relative	837:844	arg1	deviation					855:863	low relative standard deviation	833:863	low relative standard deviation (below 5.00%)	833:877	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	6	8	theme	high	781:784	arg1	recoveries					786:795	high recoveries	781:795	high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%)	781:877	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	3	9	theme	adsorption	483:492	arg1	capacity					494:501	the maximum adsorption capacity	471:501	the maximum adsorption capacity	471:501	Due to the introduction of crown ether, [KGM + DB18C6] showed good adsorption performance for Cu2+ in aqueous, and the maximum adsorption capacity was 194 mg/g under the optimal adsorption condition.
33610605	5	10	theme	[KGM + DB18C6	695:707	arg1	isotherms					682:690	The adsorption isotherms	667:690	The adsorption isotherms of [KGM + DB18C6] on Cu2+	667:716	The adsorption isotherms of [KGM + DB18C6] on Cu2+ followed the dual-site Langmuir-Freundlich model.
33610605	6	11	theme	low	833:835	arg1	deviation					855:863	low relative standard deviation	833:863	low relative standard deviation (below 5.00%)	833:877	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	6	12	from	product	909:915	arg1	samples					925:931	real samples	920:931	real samples	920:931	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	4	13	theme	[KGM + DB18C6	583:595	arg1	kinetics					571:578	The adsorption kinetics	556:578	The adsorption kinetics of [KGM + DB18C6] on Cu2+	556:604	The adsorption kinetics of [KGM + DB18C6] on Cu2+ could be described by the pseudo-second-order kinetic model.
33610605	3	14	theme	ether	389:393	arg1	introduction					367:378	the introduction	363:378	the introduction of crown ether	363:393	Due to the introduction of crown ether, [KGM + DB18C6] showed good adsorption performance for Cu2+ in aqueous, and the maximum adsorption capacity was 194 mg/g under the optimal adsorption condition.
33610605	3	15	theme	maximum	475:481	arg1	capacity					494:501	the maximum adsorption capacity	471:501	the maximum adsorption capacity	471:501	Due to the introduction of crown ether, [KGM + DB18C6] showed good adsorption performance for Cu2+ in aqueous, and the maximum adsorption capacity was 194 mg/g under the optimal adsorption condition.
33610605	3	16	from	performance	434:444	arg1	aqueous					458:464	aqueous	458:464	aqueous	458:464	Due to the introduction of crown ether, [KGM + DB18C6] showed good adsorption performance for Cu2+ in aqueous, and the maximum adsorption capacity was 194 mg/g under the optimal adsorption condition.
33610605	1	17	theme	novel	84:88	arg1	[KGM + DB18C6					130:142	A novel supramolecular polysaccharide composite [KGM + DB18C6]	82:143	A novel supramolecular polysaccharide composite [KGM + DB18C6]	82:143	A novel supramolecular polysaccharide composite [KGM + DB18C6] was prepared from konjac glucomannan (KGM) and dibenzo-18-crown-6 (DB18C6) using ceric ammonium nitrate as initiator.
33610605	6	18	from	recoveries	786:795	arg1	%					825:825	82.65 to 88.47%	811:825	82.65 to 88.47%	811:825	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	0	19	theme	Adsorption	0:9	arg1	behavior					11:18	Adsorption behavior	0:18	Adsorption behavior of copper ions	0:33	Adsorption behavior of copper ions using crown ether-modified konjac glucomannan.
33610605	1	20	theme	supramolecular	90:103	arg1	[KGM + DB18C6					130:142	A novel supramolecular polysaccharide composite [KGM + DB18C6]	82:143	A novel supramolecular polysaccharide composite [KGM + DB18C6]	82:143	A novel supramolecular polysaccharide composite [KGM + DB18C6] was prepared from konjac glucomannan (KGM) and dibenzo-18-crown-6 (DB18C6) using ceric ammonium nitrate as initiator.
33610605	3	21	theme	crown	383:387	arg1	ether					389:393	crown ether	383:393	crown ether	383:393	Due to the introduction of crown ether, [KGM + DB18C6] showed good adsorption performance for Cu2+ in aqueous, and the maximum adsorption capacity was 194 mg/g under the optimal adsorption condition.
33610605	0	22	theme	copper	23:28	arg1	ions					30:33	copper ions	23:33	copper ions	23:33	Adsorption behavior of copper ions using crown ether-modified konjac glucomannan.
33610605	1	23	theme	polysaccharide	105:118	arg1	[KGM + DB18C6					130:142	A novel supramolecular polysaccharide composite [KGM + DB18C6]	82:143	A novel supramolecular polysaccharide composite [KGM + DB18C6]	82:143	A novel supramolecular polysaccharide composite [KGM + DB18C6] was prepared from konjac glucomannan (KGM) and dibenzo-18-crown-6 (DB18C6) using ceric ammonium nitrate as initiator.
33610605	4	24	theme	adsorption	560:569	arg1	kinetics					571:578	The adsorption kinetics	556:578	The adsorption kinetics of [KGM + DB18C6] on Cu2+	556:604	The adsorption kinetics of [KGM + DB18C6] on Cu2+ could be described by the pseudo-second-order kinetic model.
33610605	1	25	theme	composite	120:128	arg1	[KGM + DB18C6					130:142	A novel supramolecular polysaccharide composite [KGM + DB18C6]	82:143	A novel supramolecular polysaccharide composite [KGM + DB18C6]	82:143	A novel supramolecular polysaccharide composite [KGM + DB18C6] was prepared from konjac glucomannan (KGM) and dibenzo-18-crown-6 (DB18C6) using ceric ammonium nitrate as initiator.
33610605	3	26	theme	good	418:421	arg1	performance					434:444	good adsorption performance	418:444	good adsorption performance for Cu2+ in aqueous	418:464	Due to the introduction of crown ether, [KGM + DB18C6] showed good adsorption performance for Cu2+ in aqueous, and the maximum adsorption capacity was 194 mg/g under the optimal adsorption condition.
33610605	5	27	theme	Langmuir-Freundlich	741:759	arg1	model					761:765	the dual-site Langmuir-Freundlich model	727:765	the dual-site Langmuir-Freundlich model	727:765	The adsorption isotherms of [KGM + DB18C6] on Cu2+ followed the dual-site Langmuir-Freundlich model.
33610605	5	28	theme	adsorption	671:680	arg1	isotherms					682:690	The adsorption isotherms	667:690	The adsorption isotherms of [KGM + DB18C6] on Cu2+	667:716	The adsorption isotherms of [KGM + DB18C6] on Cu2+ followed the dual-site Langmuir-Freundlich model.
33610605	6	29	theme	good	971:974	arg1	absorbent					976:984	a good absorbent	969:984	a good absorbent for removing Cu2+ in wastewater	969:1016	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	6	29	theme	good	971:974	arg1	[KGM + DB18C6					950:962	[KGM + DB18C6]	950:963	[KGM + DB18C6]	950:963	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	0	30	theme	ions	30:33	arg1	behavior					11:18	Adsorption behavior	0:18	Adsorption behavior of copper ions	0:33	Adsorption behavior of copper ions using crown ether-modified konjac glucomannan.
33610605	6	31	from	%	825:825	arg1	deviation					855:863	low relative standard deviation	833:863	low relative standard deviation (below 5.00%)	833:877	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	6	31	from	%	825:825	arg1	Cu2+					800:803	Cu2+	800:803	Cu2+ (from 82.65 to 88.47%)	800:826	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	6	31	from	%	825:825	arg1	recoveries					786:795	high recoveries	781:795	high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%)	781:877	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	0	32	theme	ether-modified	47:60	arg1	glucomannan					69:79	crown ether-modified konjac glucomannan	41:79	crown ether-modified konjac glucomannan	41:79	Adsorption behavior of copper ions using crown ether-modified konjac glucomannan.
33610605	4	33	from	kinetics	571:578	arg1	Cu2+					601:604	Cu2+	601:604	Cu2+	601:604	The adsorption kinetics of [KGM + DB18C6] on Cu2+ could be described by the pseudo-second-order kinetic model.
33610605	3	34	theme	optimal	526:532	arg1	condition					545:553	the optimal adsorption condition	522:553	the optimal adsorption condition	522:553	Due to the introduction of crown ether, [KGM + DB18C6] showed good adsorption performance for Cu2+ in aqueous, and the maximum adsorption capacity was 194 mg/g under the optimal adsorption condition.
33610605	0	35	theme	crown	41:45	arg1	glucomannan					69:79	crown ether-modified konjac glucomannan	41:79	crown ether-modified konjac glucomannan	41:79	Adsorption behavior of copper ions using crown ether-modified konjac glucomannan.
33610605	3	36	theme	adsorption	534:543	arg1	condition					545:553	the optimal adsorption condition	522:553	the optimal adsorption condition	522:553	Due to the introduction of crown ether, [KGM + DB18C6] showed good adsorption performance for Cu2+ in aqueous, and the maximum adsorption capacity was 194 mg/g under the optimal adsorption condition.
33610605	6	37	dep	88.47	820:824	arg1	to					817:818	to	817:818	to	817:818	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	3	38	theme	adsorption	423:432	arg1	performance					434:444	good adsorption performance	418:444	good adsorption performance for Cu2+ in aqueous	418:464	Due to the introduction of crown ether, [KGM + DB18C6] showed good adsorption performance for Cu2+ in aqueous, and the maximum adsorption capacity was 194 mg/g under the optimal adsorption condition.
33610605	1	39	theme	ceric	226:230	arg1	nitrate					241:247	ceric ammonium nitrate	226:247	ceric ammonium nitrate	226:247	A novel supramolecular polysaccharide composite [KGM + DB18C6] was prepared from konjac glucomannan (KGM) and dibenzo-18-crown-6 (DB18C6) using ceric ammonium nitrate as initiator.
33610605	6	40	theme	Cu2+	800:803	arg1	recoveries					786:795	high recoveries	781:795	high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%)	781:877	In addition, high recoveries of Cu2+ (from 82.65 to 88.47%), and low relative standard deviation (below 5.00%) were obtained by applying the product in real samples, indicating that [KGM + DB18C6] was a good absorbent for removing Cu2+ in wastewater.
33610605	1	41	theme	konjac	163:168	arg1	KGM					183:185	KGM	183:185	KGM	183:185	A novel supramolecular polysaccharide composite [KGM + DB18C6] was prepared from konjac glucomannan (KGM) and dibenzo-18-crown-6 (DB18C6) using ceric ammonium nitrate as initiator.
33610605	1	41	theme	konjac	163:168	arg1	glucomannan					170:180	konjac glucomannan	163:180	konjac glucomannan (KGM)	163:186	A novel supramolecular polysaccharide composite [KGM + DB18C6] was prepared from konjac glucomannan (KGM) and dibenzo-18-crown-6 (DB18C6) using ceric ammonium nitrate as initiator.
33610605	1	42	theme	ammonium	232:239	arg1	nitrate					241:247	ceric ammonium nitrate	226:247	ceric ammonium nitrate	226:247	A novel supramolecular polysaccharide composite [KGM + DB18C6] was prepared from konjac glucomannan (KGM) and dibenzo-18-crown-6 (DB18C6) using ceric ammonium nitrate as initiator.
33610605	4	43	theme	pseudo-second-order	632:650	arg1	model					660:664	the pseudo-second-order kinetic model	628:664	the pseudo-second-order kinetic model	628:664	The adsorption kinetics of [KGM + DB18C6] on Cu2+ could be described by the pseudo-second-order kinetic model.
33610605	0	44	theme	konjac	62:67	arg1	glucomannan					69:79	crown ether-modified konjac glucomannan	41:79	crown ether-modified konjac glucomannan	41:79	Adsorption behavior of copper ions using crown ether-modified konjac glucomannan.
33610605	2	45	theme	13C	338:340	arg1	NMR					342:344	solid-state 13C NMR	326:344	solid-state 13C NMR	326:344	The products were characterized by FTIR, TG, DSC, UV-Vis, XRD, solid-state 13C NMR, and SEM.
33075343	0	0	theme	edible	101:106	arg1	films					108:112	edible films	101:112	edible films	101:112	Physicochemical and structural characterization of sodium caseinate based film-forming solutions and edible films as affected by high methoxyl pectin.
33075343	1	1	theme	mechanical	308:317	arg1	characteristics					334:348	mechanical and structural characteristics	308:348	the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film	175:367	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	1	2	from	role	179:182	arg1	rheology					217:224	rheology	217:224	rheology	217:224	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	1	2	from	role	179:182	arg1	stability					239:247	physical stability	230:247	physical stability	230:247	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	11	3	theme	SEM	1340:1342	arg1	analysis					1344:1351	SEM analysis	1340:1351	SEM analysis	1340:1351	SEM analysis exhibited a homogenous microstructure in 50CAS:50HMP and 25CAS:75HMP.
33075343	1	4	theme	physical	230:237	arg1	stability					239:247	physical stability	230:247	physical stability	230:247	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	5	5	theme	viscosity	724:732	arg1	Analysis					693:700	Analysis	693:700	Analysis of steady-state shear viscosity of film solutions	693:750	Analysis of steady-state shear viscosity of film solutions showed a transition from Newtonian to shear-thinning flow behaviour by addition of HMP.
33075343	5	6	theme	flow	805:808	arg1	behaviour					810:818	shear-thinning flow behaviour	790:818	shear-thinning flow behaviour	790:818	Analysis of steady-state shear viscosity of film solutions showed a transition from Newtonian to shear-thinning flow behaviour by addition of HMP.
33075343	8	7	theme	destabilization	1074:1088	arg1	mechanisms					1060:1069	distinct mechanisms	1051:1069	distinct mechanisms of destabilization	1051:1088	All solutions showed distinct mechanisms of destabilization.
33075343	6	8	theme	Dynamic	840:846	arg1	evaluations					864:874	Dynamic viscoelasticity evaluations	840:874	Dynamic viscoelasticity evaluations	840:874	Dynamic viscoelasticity evaluations revealed that the elasticity of solutions decreased by increasing HMP ratio.
33075343	4	9	theme	particle	546:553	arg1	distribution					560:571	particle size distribution	546:571	particle size distribution	546:571	Turbidity and particle size distribution measurements indicated that some level of protein-polysaccharide interactions developed in 50CAS:50HMP and 25CAS:75HMP.
33075343	5	10	theme	solutions	742:750	arg1	viscosity					724:732	steady-state shear viscosity	705:732	steady-state shear viscosity of film solutions	705:750	Analysis of steady-state shear viscosity of film solutions showed a transition from Newtonian to shear-thinning flow behaviour by addition of HMP.
33075343	1	11	theme	structural	323:332	arg1	characteristics					334:348	mechanical and structural characteristics	308:348	the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film	175:367	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	3	12	theme	solution	491:498	arg1	value					478:482	pH value	475:482	pH value	475:482	Incorporation of HMP into CAS solution decreased pH value of the solution, acting as a natural acidifier.
33075343	12	13	theme	lower	1449:1453	arg1	temperatures					1472:1483	lower glass transition temperatures	1449:1483	lower glass transition temperatures	1449:1483	DSC thermograms displayed lower glass transition temperatures in HMP-incorporated films.
33075343	12	14	theme	DSC	1423:1425	arg1	thermograms					1427:1437	DSC thermograms	1423:1437	DSC thermograms	1423:1437	DSC thermograms displayed lower glass transition temperatures in HMP-incorporated films.
33075343	6	15	theme	HMP	942:944	arg1	ratio					946:950	HMP ratio	942:950	HMP ratio	942:950	Dynamic viscoelasticity evaluations revealed that the elasticity of solutions decreased by increasing HMP ratio.
33075343	3	16	theme	natural	513:519	arg1	acidifier					521:529	a natural acidifier	511:529	a natural acidifier	511:529	Incorporation of HMP into CAS solution decreased pH value of the solution, acting as a natural acidifier.
33075343	4	17	theme	distribution	560:571	arg1	measurements					573:584	Turbidity and particle size distribution measurements	532:584	Turbidity and particle size distribution measurements	532:584	Turbidity and particle size distribution measurements indicated that some level of protein-polysaccharide interactions developed in 50CAS:50HMP and 25CAS:75HMP.
33075343	5	18	theme	shear-thinning	790:803	arg1	behaviour					810:818	shear-thinning flow behaviour	790:818	shear-thinning flow behaviour	790:818	Analysis of steady-state shear viscosity of film solutions showed a transition from Newtonian to shear-thinning flow behaviour by addition of HMP.
33075343	10	19	theme	Increasing	1169:1178	arg1	CAS					1180:1182	Increasing CAS	1169:1182	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.	1169:1338	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	3	20	theme	CAS	452:454	arg1	solution					456:463	CAS solution	452:463	CAS solution	452:463	Incorporation of HMP into CAS solution decreased pH value of the solution, acting as a natural acidifier.
33075343	12	21	theme	transition	1461:1470	arg1	temperatures					1472:1483	lower glass transition temperatures	1449:1483	lower glass transition temperatures	1449:1483	DSC thermograms displayed lower glass transition temperatures in HMP-incorporated films.
33075343	10	22	theme	films	1279:1283	arg1	break					1263:1267	break	1263:1267	break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively	1263:1337	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	10	23	dep	%	1304:1304	arg1	to					1296:1297	to	1296:1297	to	1296:1297	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	4	24	theme	size	555:558	arg1	distribution					560:571	particle size distribution	546:571	particle size distribution	546:571	Turbidity and particle size distribution measurements indicated that some level of protein-polysaccharide interactions developed in 50CAS:50HMP and 25CAS:75HMP.
33075343	4	25	theme	protein-polysaccharide	615:636	arg1	interactions					638:649	protein-polysaccharide interactions	615:649	protein-polysaccharide interactions	615:649	Turbidity and particle size distribution measurements indicated that some level of protein-polysaccharide interactions developed in 50CAS:50HMP and 25CAS:75HMP.
33075343	5	26	theme	HMP	835:837	arg1	addition					823:830	addition	823:830	addition of HMP	823:837	Analysis of steady-state shear viscosity of film solutions showed a transition from Newtonian to shear-thinning flow behaviour by addition of HMP.
33075343	2	27	theme	CAS-HMP	370:376	arg1	films					378:382	CAS-HMP films	370:382	CAS-HMP films	370:382	CAS-HMP films were fabricated at different blend ratio.
33075343	1	28	theme	edible	357:362	arg1	film					364:367	its edible film	353:367	its edible film	353:367	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	9	29	theme	stable	1151:1156	arg1	samples					1119:1125	50CAS:50HMP and 25CAS:75HMP samples	1091:1125	50CAS:50HMP and 25CAS:75HMP samples	1091:1125	50CAS:50HMP and 25CAS:75HMP samples appeared to be the most stable solutions.
33075343	9	29	theme	stable	1151:1156	arg1	solutions					1158:1166	the most stable solutions	1142:1166	the most stable solutions	1142:1166	50CAS:50HMP and 25CAS:75HMP samples appeared to be the most stable solutions.
33075343	12	30	theme	glass	1455:1459	arg1	temperatures					1472:1483	lower glass transition temperatures	1449:1483	lower glass transition temperatures	1449:1483	DSC thermograms displayed lower glass transition temperatures in HMP-incorporated films.
33075343	0	31	theme	Physicochemical	0:14	arg1	characterization					31:46	Physicochemical and structural characterization	0:46	Physicochemical and structural characterization of sodium	0:56	Physicochemical and structural characterization of sodium caseinate based film-forming solutions and edible films as affected by high methoxyl pectin.
33075343	5	32	from	Newtonian	777:785	arg1	transition					761:770	a transition	759:770	a transition from Newtonian to shear-thinning flow behaviour	759:818	Analysis of steady-state shear viscosity of film solutions showed a transition from Newtonian to shear-thinning flow behaviour by addition of HMP.
33075343	11	33	theme	homogenous	1365:1374	arg1	microstructure					1376:1389	a homogenous microstructure	1363:1389	a homogenous microstructure in 50CAS:50HMP and 25CAS:75HMP	1363:1420	SEM analysis exhibited a homogenous microstructure in 50CAS:50HMP and 25CAS:75HMP.
33075343	1	34	theme	high	187:190	arg1	pectin					201:206	high methoxyl pectin	187:206	high methoxyl pectin (HMP)	187:212	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	1	34	theme	high	187:190	arg1	HMP					209:211	HMP	209:211	HMP	209:211	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	1	35	from	characteristics	334:348	arg1	rheology					217:224	rheology	217:224	rheology	217:224	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	1	35	from	characteristics	334:348	arg1	stability					239:247	physical stability	230:247	physical stability	230:247	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	0	36	theme	methoxyl	134:141	arg1	pectin					143:148	high methoxyl pectin	129:148	high methoxyl pectin	129:148	Physicochemical and structural characterization of sodium caseinate based film-forming solutions and edible films as affected by high methoxyl pectin.
33075343	7	37	theme	solutions	975:983	arg1	stability					962:970	Physical stability	953:970	Physical stability of solutions	953:983	Physical stability of solutions was assessed over time using a Turbiscanner.
33075343	10	38	dep	CAS	1180:1182	arg1	increased					1214:1222	increased	1214:1222	increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively	1214:1337	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	10	39	theme	water	1228:1232	arg1	solubility					1234:1243	the water solubility	1224:1243	the water solubility	1224:1243	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	1	40	theme	methoxyl	192:199	arg1	pectin					201:206	high methoxyl pectin	187:206	high methoxyl pectin (HMP)	187:212	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	1	40	theme	methoxyl	192:199	arg1	HMP					209:211	HMP	209:211	HMP	209:211	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	2	41	theme	blend	413:417	arg1	ratio					419:423	different blend ratio	403:423	different blend ratio	403:423	CAS-HMP films were fabricated at different blend ratio.
33075343	10	42	theme	HMP	1184:1186	arg1	ratio					1188:1192	HMP ratio	1184:1192	HMP ratio from 100:0 to 25:75	1184:1212	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	0	43	theme	high	129:132	arg1	pectin					143:148	high methoxyl pectin	129:148	high methoxyl pectin	129:148	Physicochemical and structural characterization of sodium caseinate based film-forming solutions and edible films as affected by high methoxyl pectin.
33075343	1	44	theme	film	364:367	arg1	role					179:182	the role	175:182	the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film	175:367	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	1	44	theme	film	364:367	arg1	characteristics					334:348	mechanical and structural characteristics	308:348	the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film	175:367	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	10	45	from	%	1304:1304	arg1	break					1263:1267	break	1263:1267	break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively	1263:1337	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	10	45	from	%	1304:1304	arg1	films					1279:1283	edible films	1272:1283	edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively	1272:1337	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	1	46	theme	pectin	201:206	arg1	role					179:182	the role	175:182	the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film	175:367	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	1	46	theme	pectin	201:206	arg1	characteristics					334:348	mechanical and structural characteristics	308:348	the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film	175:367	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	0	47	theme	sodium	51:56	arg1	characterization					31:46	Physicochemical and structural characterization	0:46	Physicochemical and structural characterization of sodium	0:56	Physicochemical and structural characterization of sodium caseinate based film-forming solutions and edible films as affected by high methoxyl pectin.
33075343	4	48	theme	Turbidity	532:540	arg1	measurements					573:584	Turbidity and particle size distribution measurements	532:584	Turbidity and particle size distribution measurements	532:584	Turbidity and particle size distribution measurements indicated that some level of protein-polysaccharide interactions developed in 50CAS:50HMP and 25CAS:75HMP.
33075343	1	49	theme	film-forming	275:286	arg1	solution					288:295	sodium caseinate (CAS) film-forming solution	252:295	sodium caseinate (CAS) film-forming solution	252:295	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	5	50	theme	film	737:740	arg1	solutions					742:750	film solutions	737:750	film solutions	737:750	Analysis of steady-state shear viscosity of film solutions showed a transition from Newtonian to shear-thinning flow behaviour by addition of HMP.
33075343	0	51	dep	caseinate	58:66	arg1	based					68:72	based	68:72	caseinate based film-forming solutions and edible films as affected by high methoxyl pectin	58:148	Physicochemical and structural characterization of sodium caseinate based film-forming solutions and edible films as affected by high methoxyl pectin.
33075343	13	52	from	biopolymers	1547:1557	arg1	biocomposites					1562:1574	biocomposites	1562:1574	biocomposites	1562:1574	Presence of the interactions among biopolymers in biocomposites was confirmed by FTIR spectra.
33075343	3	53	theme	HMP	443:445	arg1	Incorporation					426:438	Incorporation	426:438	Incorporation of HMP into CAS solution	426:463	Incorporation of HMP into CAS solution decreased pH value of the solution, acting as a natural acidifier.
33075343	1	54	theme	solution	288:295	arg1	rheology					217:224	rheology	217:224	rheology	217:224	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	1	54	theme	solution	288:295	arg1	stability					239:247	physical stability	230:247	physical stability	230:247	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	6	55	theme	solutions	908:916	arg1	elasticity					894:903	the elasticity	890:903	the elasticity of solutions	890:916	Dynamic viscoelasticity evaluations revealed that the elasticity of solutions decreased by increasing HMP ratio.
33075343	3	56	theme	pH	475:476	arg1	value					478:482	pH value	475:482	pH value	475:482	Incorporation of HMP into CAS solution decreased pH value of the solution, acting as a natural acidifier.
33075343	13	57	theme	interactions	1528:1539	arg1	Presence					1512:1519	Presence	1512:1519	Presence of the interactions among biopolymers in biocomposites	1512:1574	Presence of the interactions among biopolymers in biocomposites was confirmed by FTIR spectra.
33075343	5	58	theme	shear	718:722	arg1	viscosity					724:732	steady-state shear viscosity	705:732	steady-state shear viscosity of film solutions	705:750	Analysis of steady-state shear viscosity of film solutions showed a transition from Newtonian to shear-thinning flow behaviour by addition of HMP.
33075343	10	59	from	100:0	1199:1203	arg1	ratio					1188:1192	HMP ratio	1184:1192	HMP ratio from 100:0 to 25:75	1184:1212	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	7	60	theme	Physical	953:960	arg1	stability					962:970	Physical stability	953:970	Physical stability of solutions	953:983	Physical stability of solutions was assessed over time using a Turbiscanner.
33075343	10	61	from	break	1263:1267	arg1	%					1323:1323	2.36 to 16.53%	1310:1323	2.36 to 16.53%	1310:1323	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	10	61	from	break	1263:1267	arg1	%					1304:1304	27.16 to 63.70%	1290:1304	27.16 to 63.70%	1290:1304	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	12	62	theme	HMP-incorporated	1488:1503	arg1	films					1505:1509	HMP-incorporated films	1488:1509	HMP-incorporated films	1488:1509	DSC thermograms displayed lower glass transition temperatures in HMP-incorporated films.
33075343	8	63	theme	distinct	1051:1058	arg1	mechanisms					1060:1069	distinct mechanisms	1051:1069	distinct mechanisms of destabilization	1051:1088	All solutions showed distinct mechanisms of destabilization.
33075343	13	64	theme	FTIR	1593:1596	arg1	spectra					1598:1604	FTIR spectra	1593:1604	FTIR spectra	1593:1604	Presence of the interactions among biopolymers in biocomposites was confirmed by FTIR spectra.
33075343	5	65	theme	steady-state	705:716	arg1	viscosity					724:732	steady-state shear viscosity	705:732	steady-state shear viscosity of film solutions	705:750	Analysis of steady-state shear viscosity of film solutions showed a transition from Newtonian to shear-thinning flow behaviour by addition of HMP.
33075343	9	66	theme	50CAS:50HMP	1091:1101	arg1	samples					1119:1125	50CAS:50HMP and 25CAS:75HMP samples	1091:1125	50CAS:50HMP and 25CAS:75HMP samples	1091:1125	50CAS:50HMP and 25CAS:75HMP samples appeared to be the most stable solutions.
33075343	9	66	theme	50CAS:50HMP	1091:1101	arg1	solutions					1158:1166	the most stable solutions	1142:1166	the most stable solutions	1142:1166	50CAS:50HMP and 25CAS:75HMP samples appeared to be the most stable solutions.
33075343	4	67	theme	interactions	638:649	arg1	level					606:610	some level	601:610	some level of protein-polysaccharide interactions	601:649	Turbidity and particle size distribution measurements indicated that some level of protein-polysaccharide interactions developed in 50CAS:50HMP and 25CAS:75HMP.
33075343	2	68	theme	different	403:411	arg1	ratio					419:423	different blend ratio	403:423	different blend ratio	403:423	CAS-HMP films were fabricated at different blend ratio.
33075343	1	69	theme	Present	151:157	arg1	work					159:162	Present work	151:162	Present work	151:162	Present work focused on the role of high methoxyl pectin (HMP) in rheology and physical stability of sodium caseinate (CAS) film-forming solution as well as mechanical and structural characteristics of its edible film.
33075343	10	70	theme	edible	1272:1277	arg1	films					1279:1283	edible films	1272:1283	edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively	1272:1337	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	6	71	theme	viscoelasticity	848:862	arg1	evaluations					864:874	Dynamic viscoelasticity evaluations	840:874	Dynamic viscoelasticity evaluations	840:874	Dynamic viscoelasticity evaluations revealed that the elasticity of solutions decreased by increasing HMP ratio.
33075343	0	72	theme	film-forming	74:85	arg1	solutions					87:95	film-forming solutions	74:95	film-forming solutions	74:95	Physicochemical and structural characterization of sodium caseinate based film-forming solutions and edible films as affected by high methoxyl pectin.
33075343	11	73	from	microstructure	1376:1389	arg1	25CAS:75HMP					1410:1420	25CAS:75HMP	1410:1420	25CAS:75HMP	1410:1420	SEM analysis exhibited a homogenous microstructure in 50CAS:50HMP and 25CAS:75HMP.
33075343	11	73	from	microstructure	1376:1389	arg1	50CAS:50HMP					1394:1404	50CAS:50HMP	1394:1404	50CAS:50HMP	1394:1404	SEM analysis exhibited a homogenous microstructure in 50CAS:50HMP and 25CAS:75HMP.
33075343	0	74	theme	structural	20:29	arg1	characterization					31:46	Physicochemical and structural characterization	0:46	Physicochemical and structural characterization of sodium	0:56	Physicochemical and structural characterization of sodium caseinate based film-forming solutions and edible films as affected by high methoxyl pectin.
33075343	10	75	dep	%	1323:1323	arg1	to					1315:1316	to	1315:1316	to	1315:1316	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	10	76	from	%	1323:1323	arg1	break					1263:1267	break	1263:1267	break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively	1263:1337	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	10	76	from	%	1323:1323	arg1	films					1279:1283	edible films	1272:1283	edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively	1272:1337	Increasing CAS:HMP ratio from 100:0 to 25:75 increased the water solubility and elongation at break of edible films from 27.16 to 63.70% and 2.36 to 16.53%, respectively.
33075343	9	77	theme	25CAS:75HMP	1107:1117	arg1	samples					1119:1125	50CAS:50HMP and 25CAS:75HMP samples	1091:1125	50CAS:50HMP and 25CAS:75HMP samples	1091:1125	50CAS:50HMP and 25CAS:75HMP samples appeared to be the most stable solutions.
33075343	9	77	theme	25CAS:75HMP	1107:1117	arg1	solutions					1158:1166	the most stable solutions	1142:1166	the most stable solutions	1142:1166	50CAS:50HMP and 25CAS:75HMP samples appeared to be the most stable solutions.
34481857	4	0	theme	hydrophobic	966:976	arg1	properties					978:987	the beeswax's hydrophobic properties	952:987	the beeswax's hydrophobic properties in improving water barrier of the TPCS-BW bio-composite	952:1043	Incorporation of 10 wt% beeswax has successfully produced the lowest value of moisture absorption and water solubility among the bio-composite which might be attributed to the beeswax's hydrophobic properties in improving water barrier of the TPCS-BW bio-composite.
34481857	6	1	theme	beeswax	1243:1249	arg1	incorporation					1226:1238	incorporation	1226:1238	incorporation of beeswax in the mixture	1226:1264	Meanwhile, fourier transform infrared (FT-IR) spectroscopy presented that incorporation of beeswax in the mixture has considerably improve hydrogen bonding of blends indicating good interaction between starch and beeswax.
34481857	7	2	theme	functional	1443:1452	arg1	properties					1454:1463	the functional properties	1439:1463	the functional properties of TPCS-BW bio-composite	1439:1488	Hence, beeswax with an appropriate loading value able to improve the functional properties of TPCS-BW bio-composite.
34481857	0	3	theme	absorption	88:97	arg1	properties					99:108	thermal mechanical and moisture absorption properties	56:108	thermal mechanical and moisture absorption properties	56:108	Thermoplastic starch/beeswax blend: Characterization on thermal mechanical and moisture absorption properties.
34481857	4	4	theme	lowest	842:847	arg1	value					849:853	the lowest value	838:853	the lowest value of moisture absorption and water solubility	838:897	Incorporation of 10 wt% beeswax has successfully produced the lowest value of moisture absorption and water solubility among the bio-composite which might be attributed to the beeswax's hydrophobic properties in improving water barrier of the TPCS-BW bio-composite.
34481857	6	5	from	incorporation	1226:1238	arg1	mixture					1258:1264	the mixture	1254:1264	the mixture	1254:1264	Meanwhile, fourier transform infrared (FT-IR) spectroscopy presented that incorporation of beeswax in the mixture has considerably improve hydrogen bonding of blends indicating good interaction between starch and beeswax.
34481857	4	6	theme	water	882:886	arg1	solubility					888:897	water solubility	882:897	water solubility	882:897	Incorporation of 10 wt% beeswax has successfully produced the lowest value of moisture absorption and water solubility among the bio-composite which might be attributed to the beeswax's hydrophobic properties in improving water barrier of the TPCS-BW bio-composite.
34481857	1	7	theme	petroleum-based	319:333	arg1	plastic					335:341	petroleum-based plastic	319:341	petroleum-based plastic	319:341	Cassava starch has acquired many attentions owing to its ability to be developed as thermoplastic cassava starch (TPCS) where it can be obtained in low cost, making it to be one of alternatives to substitute petroleum-based plastic.
34481857	2	8	theme	loading	575:581	arg1	range					558:562	the range	554:562	the range of beeswax loading from 0, 2.5, 5 to 10 wt%	554:606	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	4	9	theme	bio-composite	1031:1043	arg1	barrier					1008:1014	water barrier	1002:1014	water barrier of the TPCS-BW bio-composite	1002:1043	Incorporation of 10 wt% beeswax has successfully produced the lowest value of moisture absorption and water solubility among the bio-composite which might be attributed to the beeswax's hydrophobic properties in improving water barrier of the TPCS-BW bio-composite.
34481857	3	10	dep	beeswax	621:627	arg1	has					629:631	has	629:631	has	629:631	Addition of beeswax has significantly reduced tensile strength, elongation and flexural strength while improving tensile modulus and flexural modulus until 5 wt% beeswax.
34481857	2	11	theme	beeswax	567:573	arg1	loading					575:581	beeswax loading	567:581	beeswax loading from 0, 2.5, 5 to 10 wt%	567:606	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	1	12	theme	low	259:261	arg1	cost					263:266	low cost	259:266	low cost	259:266	Cassava starch has acquired many attentions owing to its ability to be developed as thermoplastic cassava starch (TPCS) where it can be obtained in low cost, making it to be one of alternatives to substitute petroleum-based plastic.
34481857	3	13	theme	flexural	688:695	arg1	strength					697:704	flexural strength	688:704	flexural strength	688:704	Addition of beeswax has significantly reduced tensile strength, elongation and flexural strength while improving tensile modulus and flexural modulus until 5 wt% beeswax.
34481857	4	14	theme	beeswax	804:810	arg1	Incorporation					780:792	Incorporation	780:792	Incorporation of 10 wt% beeswax	780:810	Incorporation of 10 wt% beeswax has successfully produced the lowest value of moisture absorption and water solubility among the bio-composite which might be attributed to the beeswax's hydrophobic properties in improving water barrier of the TPCS-BW bio-composite.
34481857	2	15	from	range	558:562	arg1	%					606:606	0, 2.5, 5 to 10 wt%	588:606	0, 2.5, 5 to 10 wt%	588:606	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	4	16	theme	%	802:802	arg1	beeswax					804:810	10 wt% beeswax	797:810	10 wt% beeswax	797:810	Incorporation of 10 wt% beeswax has successfully produced the lowest value of moisture absorption and water solubility among the bio-composite which might be attributed to the beeswax's hydrophobic properties in improving water barrier of the TPCS-BW bio-composite.
34481857	0	17	theme	Thermoplastic	0:12	arg1	blend					29:33	Thermoplastic starch/beeswax blend	0:33	Thermoplastic starch/beeswax blend	0:33	Thermoplastic starch/beeswax blend: Characterization on thermal mechanical and moisture absorption properties.
34481857	0	18	theme	starch/beeswax	14:27	arg1	blend					29:33	Thermoplastic starch/beeswax blend	0:33	Thermoplastic starch/beeswax blend	0:33	Thermoplastic starch/beeswax blend: Characterization on thermal mechanical and moisture absorption properties.
34481857	0	19	from	Characterization	36:51	arg1	properties					99:108	thermal mechanical and moisture absorption properties	56:108	thermal mechanical and moisture absorption properties	56:108	Thermoplastic starch/beeswax blend: Characterization on thermal mechanical and moisture absorption properties.
34481857	7	20	theme	appropriate	1397:1407	arg1	value					1417:1421	an appropriate loading value	1394:1421	an appropriate loading value	1394:1421	Hence, beeswax with an appropriate loading value able to improve the functional properties of TPCS-BW bio-composite.
34481857	5	21	theme	beeswax	1075:1081	arg1	addition					1063:1070	the addition	1059:1070	the addition of beeswax	1059:1081	Furthermore, the addition of beeswax resulted in the appearance of irregular and rough fractured surface.
34481857	2	22	theme	absorption	416:425	arg1	properties					427:436	the thermal, mechanical and moisture absorption properties	379:436	the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%	379:606	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	6	23	theme	infrared	1181:1188	arg1	spectroscopy					1198:1209	infrared (FT-IR) spectroscopy	1181:1209	infrared (FT-IR) spectroscopy	1181:1209	Meanwhile, fourier transform infrared (FT-IR) spectroscopy presented that incorporation of beeswax in the mixture has considerably improve hydrogen bonding of blends indicating good interaction between starch and beeswax.
34481857	1	24	theme	Cassava	111:117	arg1	starch					119:124	Cassava starch	111:124	Cassava starch	111:124	Cassava starch has acquired many attentions owing to its ability to be developed as thermoplastic cassava starch (TPCS) where it can be obtained in low cost, making it to be one of alternatives to substitute petroleum-based plastic.
34481857	6	25	theme	good	1329:1332	arg1	interaction					1334:1344	good interaction	1329:1344	good interaction between starch and beeswax	1329:1371	Meanwhile, fourier transform infrared (FT-IR) spectroscopy presented that incorporation of beeswax in the mixture has considerably improve hydrogen bonding of blends indicating good interaction between starch and beeswax.
34481857	1	26	theme	thermoplastic	195:207	arg1	starch					217:222	thermoplastic cassava starch	195:222	thermoplastic cassava starch (TPCS) where it can be obtained in low cost, making it to be one of alternatives to substitute petroleum-based plastic	195:341	Cassava starch has acquired many attentions owing to its ability to be developed as thermoplastic cassava starch (TPCS) where it can be obtained in low cost, making it to be one of alternatives to substitute petroleum-based plastic.
34481857	1	26	theme	thermoplastic	195:207	arg1	TPCS					225:228	TPCS	225:228	TPCS	225:228	Cassava starch has acquired many attentions owing to its ability to be developed as thermoplastic cassava starch (TPCS) where it can be obtained in low cost, making it to be one of alternatives to substitute petroleum-based plastic.
34481857	2	27	theme	moisture	407:414	arg1	properties					427:436	the thermal, mechanical and moisture absorption properties	379:436	the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%	379:606	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	3	28	theme	tensile	722:728	arg1	modulus					730:736	tensile modulus	722:736	tensile modulus	722:736	Addition of beeswax has significantly reduced tensile strength, elongation and flexural strength while improving tensile modulus and flexural modulus until 5 wt% beeswax.
34481857	4	29	theme	solubility	888:897	arg1	value					849:853	the lowest value	838:853	the lowest value of moisture absorption and water solubility	838:897	Incorporation of 10 wt% beeswax has successfully produced the lowest value of moisture absorption and water solubility among the bio-composite which might be attributed to the beeswax's hydrophobic properties in improving water barrier of the TPCS-BW bio-composite.
34481857	1	30	theme	cassava	209:215	arg1	starch					217:222	thermoplastic cassava starch	195:222	thermoplastic cassava starch (TPCS) where it can be obtained in low cost, making it to be one of alternatives to substitute petroleum-based plastic	195:341	Cassava starch has acquired many attentions owing to its ability to be developed as thermoplastic cassava starch (TPCS) where it can be obtained in low cost, making it to be one of alternatives to substitute petroleum-based plastic.
34481857	1	30	theme	cassava	209:215	arg1	TPCS					225:228	TPCS	225:228	TPCS	225:228	Cassava starch has acquired many attentions owing to its ability to be developed as thermoplastic cassava starch (TPCS) where it can be obtained in low cost, making it to be one of alternatives to substitute petroleum-based plastic.
34481857	7	31	theme	loading	1409:1415	arg1	value					1417:1421	an appropriate loading value	1394:1421	an appropriate loading value	1394:1421	Hence, beeswax with an appropriate loading value able to improve the functional properties of TPCS-BW bio-composite.
34481857	2	32	theme	compression	532:542	arg1	method					544:549	hot moulding compression method	519:549	hot moulding compression method	519:549	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	2	33	theme	starch	463:468	arg1	properties					427:436	the thermal, mechanical and moisture absorption properties	379:436	the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%	379:606	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	2	34	theme	moulding	523:530	arg1	method					544:549	hot moulding compression method	519:549	hot moulding compression method	519:549	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	6	35	dep	fourier	1163:1169	arg1	transform					1171:1179	transform	1171:1179	transform infrared (FT-IR) spectroscopy	1171:1209	Meanwhile, fourier transform infrared (FT-IR) spectroscopy presented that incorporation of beeswax in the mixture has considerably improve hydrogen bonding of blends indicating good interaction between starch and beeswax.
34481857	2	36	theme	thermal	383:389	arg1	properties					427:436	the thermal, mechanical and moisture absorption properties	379:436	the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%	379:606	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	2	37	theme	cassava	455:461	arg1	starch					463:468	thermoplastic cassava starch	441:468	thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%	441:606	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	3	38	theme	flexural	742:749	arg1	modulus					751:757	flexural modulus	742:757	flexural modulus	742:757	Addition of beeswax has significantly reduced tensile strength, elongation and flexural strength while improving tensile modulus and flexural modulus until 5 wt% beeswax.
34481857	2	39	theme	hot	519:521	arg1	method					544:549	hot moulding compression method	519:549	hot moulding compression method	519:549	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	4	40	theme	TPCS-BW	1023:1029	arg1	bio-composite					1031:1043	the TPCS-BW bio-composite	1019:1043	the TPCS-BW bio-composite	1019:1043	Incorporation of 10 wt% beeswax has successfully produced the lowest value of moisture absorption and water solubility among the bio-composite which might be attributed to the beeswax's hydrophobic properties in improving water barrier of the TPCS-BW bio-composite.
34481857	7	41	with	beeswax	1381:1387	arg1	value					1417:1421	an appropriate loading value	1394:1421	an appropriate loading value	1394:1421	Hence, beeswax with an appropriate loading value able to improve the functional properties of TPCS-BW bio-composite.
34481857	0	42	theme	mechanical	64:73	arg1	properties					99:108	thermal mechanical and moisture absorption properties	56:108	thermal mechanical and moisture absorption properties	56:108	Thermoplastic starch/beeswax blend: Characterization on thermal mechanical and moisture absorption properties.
34481857	5	43	theme	rough	1127:1131	arg1	surface					1143:1149	irregular and rough fractured surface	1113:1149	irregular and rough fractured surface	1113:1149	Furthermore, the addition of beeswax resulted in the appearance of irregular and rough fractured surface.
34481857	4	44	theme	moisture	858:865	arg1	absorption					867:876	moisture absorption	858:876	moisture absorption	858:876	Incorporation of 10 wt% beeswax has successfully produced the lowest value of moisture absorption and water solubility among the bio-composite which might be attributed to the beeswax's hydrophobic properties in improving water barrier of the TPCS-BW bio-composite.
34481857	4	45	theme	10 wt	797:801	arg1	beeswax					804:810	10 wt% beeswax	797:810	10 wt% beeswax	797:810	Incorporation of 10 wt% beeswax has successfully produced the lowest value of moisture absorption and water solubility among the bio-composite which might be attributed to the beeswax's hydrophobic properties in improving water barrier of the TPCS-BW bio-composite.
34481857	0	46	theme	thermal	56:62	arg1	properties					99:108	thermal mechanical and moisture absorption properties	56:108	thermal mechanical and moisture absorption properties	56:108	Thermoplastic starch/beeswax blend: Characterization on thermal mechanical and moisture absorption properties.
34481857	5	47	theme	fractured	1133:1141	arg1	surface					1143:1149	irregular and rough fractured surface	1113:1149	irregular and rough fractured surface	1113:1149	Furthermore, the addition of beeswax resulted in the appearance of irregular and rough fractured surface.
34481857	3	48	theme	tensile	655:661	arg1	strength					663:670	tensile strength	655:670	tensile strength	655:670	Addition of beeswax has significantly reduced tensile strength, elongation and flexural strength while improving tensile modulus and flexural modulus until 5 wt% beeswax.
34481857	3	49	theme	beeswax	621:627	arg1	Addition					609:616	Addition	609:616	Addition of beeswax has	609:631	Addition of beeswax has significantly reduced tensile strength, elongation and flexural strength while improving tensile modulus and flexural modulus until 5 wt% beeswax.
34481857	0	50	dep	Characterization	36:51	arg1	blend					29:33	Thermoplastic starch/beeswax blend	0:33	Thermoplastic starch/beeswax blend	0:33	Thermoplastic starch/beeswax blend: Characterization on thermal mechanical and moisture absorption properties.
34481857	1	51	theme	many	139:142	arg1	attentions					144:153	many attentions	139:153	many attentions owing to its ability to be developed as thermoplastic cassava starch (TPCS) where it can be obtained in low cost, making it to be one of alternatives to substitute petroleum-based plastic	139:341	Cassava starch has acquired many attentions owing to its ability to be developed as thermoplastic cassava starch (TPCS) where it can be obtained in low cost, making it to be one of alternatives to substitute petroleum-based plastic.
34481857	7	52	theme	bio-composite	1476:1488	arg1	properties					1454:1463	the functional properties	1439:1463	the functional properties of TPCS-BW bio-composite	1439:1488	Hence, beeswax with an appropriate loading value able to improve the functional properties of TPCS-BW bio-composite.
34481857	5	53	theme	surface	1143:1149	arg1	appearance					1099:1108	the appearance	1095:1108	the appearance of irregular and rough fractured surface	1095:1149	Furthermore, the addition of beeswax resulted in the appearance of irregular and rough fractured surface.
34481857	6	54	theme	hydrogen	1291:1298	arg1	bonding					1300:1306	hydrogen bonding	1291:1306	hydrogen bonding of blends	1291:1316	Meanwhile, fourier transform infrared (FT-IR) spectroscopy presented that incorporation of beeswax in the mixture has considerably improve hydrogen bonding of blends indicating good interaction between starch and beeswax.
34481857	6	55	theme	FT-IR	1191:1195	arg1	spectroscopy					1198:1209	infrared (FT-IR) spectroscopy	1181:1209	infrared (FT-IR) spectroscopy	1181:1209	Meanwhile, fourier transform infrared (FT-IR) spectroscopy presented that incorporation of beeswax in the mixture has considerably improve hydrogen bonding of blends indicating good interaction between starch and beeswax.
34481857	6	56	theme	blends	1311:1316	arg1	bonding					1300:1306	hydrogen bonding	1291:1306	hydrogen bonding of blends	1291:1316	Meanwhile, fourier transform infrared (FT-IR) spectroscopy presented that incorporation of beeswax in the mixture has considerably improve hydrogen bonding of blends indicating good interaction between starch and beeswax.
34481857	3	57	theme	%	769:769	arg1	beeswax					771:777	5 wt% beeswax	765:777	5 wt% beeswax	765:777	Addition of beeswax has significantly reduced tensile strength, elongation and flexural strength while improving tensile modulus and flexural modulus until 5 wt% beeswax.
34481857	4	58	theme	absorption	867:876	arg1	value					849:853	the lowest value	838:853	the lowest value of moisture absorption and water solubility	838:897	Incorporation of 10 wt% beeswax has successfully produced the lowest value of moisture absorption and water solubility among the bio-composite which might be attributed to the beeswax's hydrophobic properties in improving water barrier of the TPCS-BW bio-composite.
34481857	2	59	from	%	606:606	arg1	range					558:562	the range	554:562	the range of beeswax loading from 0, 2.5, 5 to 10 wt%	554:606	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	2	59	from	%	606:606	arg1	loading					575:581	beeswax loading	567:581	beeswax loading from 0, 2.5, 5 to 10 wt%	567:606	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	0	60	theme	moisture	79:86	arg1	properties					99:108	thermal mechanical and moisture absorption properties	56:108	thermal mechanical and moisture absorption properties	56:108	Thermoplastic starch/beeswax blend: Characterization on thermal mechanical and moisture absorption properties.
34481857	5	61	theme	irregular	1113:1121	arg1	surface					1143:1149	irregular and rough fractured surface	1113:1149	irregular and rough fractured surface	1113:1149	Furthermore, the addition of beeswax resulted in the appearance of irregular and rough fractured surface.
34481857	2	62	theme	mechanical	392:401	arg1	properties					427:436	the thermal, mechanical and moisture absorption properties	379:436	the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%	379:606	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	2	63	theme	thermoplastic	441:453	arg1	starch					463:468	thermoplastic cassava starch	441:468	thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%	441:606	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	1	64	theme	alternatives	292:303	arg1	alternatives					292:303	alternatives	292:303	alternatives	292:303	Cassava starch has acquired many attentions owing to its ability to be developed as thermoplastic cassava starch (TPCS) where it can be obtained in low cost, making it to be one of alternatives to substitute petroleum-based plastic.
34481857	1	64	theme	alternatives	292:303	arg1	one					285:287	one	285:287	one	285:287	Cassava starch has acquired many attentions owing to its ability to be developed as thermoplastic cassava starch (TPCS) where it can be obtained in low cost, making it to be one of alternatives to substitute petroleum-based plastic.
34481857	4	65	theme	water	1002:1006	arg1	barrier					1008:1014	water barrier	1002:1014	water barrier of the TPCS-BW bio-composite	1002:1043	Incorporation of 10 wt% beeswax has successfully produced the lowest value of moisture absorption and water solubility among the bio-composite which might be attributed to the beeswax's hydrophobic properties in improving water barrier of the TPCS-BW bio-composite.
34481857	2	66	dep	10 wt	601:605	arg1	to					598:599	to	598:599	to	598:599	An attempt was made to investigate the thermal, mechanical and moisture absorption properties of thermoplastic cassava starch blending with beeswax (TPCS-BW) fabricated using hot moulding compression method in the range of beeswax loading from 0, 2.5, 5 to 10 wt%.
34481857	3	67	theme	5 wt	765:768	arg1	beeswax					771:777	5 wt% beeswax	765:777	5 wt% beeswax	765:777	Addition of beeswax has significantly reduced tensile strength, elongation and flexural strength while improving tensile modulus and flexural modulus until 5 wt% beeswax.
33251585	5	0	theme	controlled	1582:1591	arg1	experiments					1593:1603	independent controlled experiments	1570:1603	independent controlled experiments with grasses	1570:1616	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	3	1	theme	δ18	728:730	arg1	Ocellulose					732:741	Modelled δ18 Ocellulose	719:741	Modelled δ18 Ocellulose	719:741	Modelled δ18 Ocellulose agreed best with observations when integrated over c. 400 growing-degree-days, similar to the average leaf lifespan observed at the site.
33251585	6	2	theme	pex	1732:1734	arg1	px					1736:1737	pex px	1732:1737	pex px	1732:1737	Understanding physiological information in δ18 Ocellulose requires quantitative knowledge of climatic effects on pex px and εbio .
33251585	5	3	from	oxygen	1426:1431	arg1	cellulose					1436:1444	cellulose	1436:1444	cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63)	1436:1513	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	4	theme	cellulose	1248:1256	arg1	synthesis					1258:1266	cellulose synthesis	1248:1266	cellulose synthesis (εbio , range 26-30‰)	1248:1288	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	4	theme	cellulose	1248:1256	arg1	εbio					1269:1272	εbio	1269:1272	εbio	1269:1272	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	5	theme	negative	1097:1104	arg1	relationship					1106:1117	their negative relationship	1091:1117	their negative relationship	1091:1117	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	4	6	theme	integration	890:900	arg1	time					902:905	the integration time	886:905	the integration time	886:905	Over the integration time, air temperature ranged from 7 to 22°C and midday relative humidity from 47 to 73%.
33251585	5	7	theme	oxygen	1426:1431	arg1	proportion					1412:1421	the proportion	1408:1421	the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63)	1408:1513	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	7	theme	oxygen	1426:1431	arg1	dependent					1519:1527	dependent	1519:1527	dependent	1519:1527	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	8	theme	biochemical	1185:1195	arg1	temperature-sensitive					1294:1314	temperature-sensitive	1294:1314	temperature-sensitive	1294:1314	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	8	theme	biochemical	1185:1195	arg1	O-fractionation					1200:1214	the biochemical 18 O-fractionation	1181:1214	the biochemical 18 O-fractionation between water	1181:1228	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	6	9	from	px	1736:1737	arg1	knowledge					1699:1707	quantitative knowledge	1686:1707	quantitative knowledge of climatic effects on pex px and εbio	1686:1746	Understanding physiological information in δ18 Ocellulose requires quantitative knowledge of climatic effects on pex px and εbio .
33251585	1	10	theme	drought-prone	360:372	arg1	ecosystem					395:403	a drought-prone, temperate grassland ecosystem	358:403	a drought-prone, temperate grassland ecosystem	358:403	We explore here our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem.
33251585	2	11	theme	Ocellulose	615:624	arg1	variation					598:606	seasonal (April-October) and multi-annual (2007-2012) variation	544:606	variation	598:606	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	2	11	theme	Ocellulose	615:624	arg1	O-enrichment					633:644	18 O-enrichment	630:644	18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model	630:716	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	2	11	theme	Ocellulose	615:624	arg1	April-October					554:566	seasonal (April-October) and multi-annual (2007-2012) variation	544:606	April-October	554:566	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	6	12	from	εbio	1743:1746	arg1	knowledge					1699:1707	quantitative knowledge	1686:1707	quantitative knowledge of climatic effects on pex px and εbio	1686:1746	Understanding physiological information in δ18 Ocellulose requires quantitative knowledge of climatic effects on pex px and εbio .
33251585	0	13	theme	δ18	117:119	arg1	O					121:121	δ18 O	117:121	δ18 O of cellulose from leaf water	117:150	Temperature-sensitive biochemical 18 O-fractionation and humidity-dependent attenuation factor are needed to predict δ18 O of cellulose from leaf water in a grassland ecosystem.
33251585	5	14	dep	εbio	1269:1272	arg1	range					1276:1280	range 26-30‰	1276:1287	range 26-30‰	1276:1287	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	1	15	theme	oxygen	292:297	arg1	composition					307:317	the oxygen isotope composition	288:317	the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem	288:403	We explore here our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem.
33251585	0	16	theme	cellulose	126:134	arg1	O					121:121	δ18 O	117:121	δ18 O of cellulose from leaf water	117:150	Temperature-sensitive biochemical 18 O-fractionation and humidity-dependent attenuation factor are needed to predict δ18 O of cellulose from leaf water in a grassland ecosystem.
33251585	2	17	theme	cellulose	654:662	arg1	variation					598:606	seasonal (April-October) and multi-annual (2007-2012) variation	544:606	variation	598:606	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	2	17	theme	cellulose	654:662	arg1	O-enrichment					633:644	18 O-enrichment	630:644	18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model	630:716	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	2	17	theme	cellulose	654:662	arg1	April-October					554:566	seasonal (April-October) and multi-annual (2007-2012) variation	544:606	April-October	554:566	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	6	18	theme	physiological	1633:1645	arg1	information					1647:1657	physiological information	1633:1657	physiological information	1633:1657	Understanding physiological information in δ18 Ocellulose requires quantitative knowledge of climatic effects on pex px and εbio .
33251585	2	19	theme	allocation-and-growth	412:432	arg1	model					434:438	A new allocation-and-growth model	406:438	A new allocation-and-growth model	406:438	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	2	20	theme	O-enabled	472:480	arg1	MuSICA					525:530	MuSICA	525:530	MuSICA	525:530	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	2	20	theme	O-enabled	472:480	arg1	model					518:522	an 18 O-enabled soil-vegetation-atmosphere transfer model	466:522	an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA)	466:531	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	1	21	theme	grassland	385:393	arg1	ecosystem					395:403	a drought-prone, temperate grassland ecosystem	358:403	a drought-prone, temperate grassland ecosystem	358:403	We explore here our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem.
33251585	2	22	theme	leaf	649:652	arg1	Ocellulose					669:678	Δ18 Ocellulose	665:678	Δ18 Ocellulose	665:678	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	2	22	theme	leaf	649:652	arg1	cellulose					654:662	leaf cellulose	649:662	leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model	649:716	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	2	23	theme	Barbour-Farquhar	695:710	arg1	model					712:716	the Barbour-Farquhar model	691:716	the Barbour-Farquhar model	691:716	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	3	24	theme	leaf	845:848	arg1	lifespan					850:857	the average leaf lifespan	833:857	the average leaf lifespan observed at the site	833:878	Modelled δ18 Ocellulose agreed best with observations when integrated over c. 400 growing-degree-days, similar to the average leaf lifespan observed at the site.
33251585	2	25	theme	seasonal	544:551	arg1	April-October					554:566	seasonal (April-October) and multi-annual (2007-2012) variation	544:606	April-October	554:566	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	0	26	theme	biochemical	22:32	arg1	O-fractionation					37:51	Temperature-sensitive biochemical 18 O-fractionation	0:51	Temperature-sensitive biochemical 18 O-fractionation	0:51	Temperature-sensitive biochemical 18 O-fractionation and humidity-dependent attenuation factor are needed to predict δ18 O of cellulose from leaf water in a grassland ecosystem.
33251585	5	27	with	agreement	997:1005	arg1	observations					1012:1023	observations	1012:1023	observations	1012:1023	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	27	with	agreement	997:1005	arg1	relationship					1106:1117	their negative relationship	1091:1117	their negative relationship	1091:1117	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	27	with	agreement	997:1005	arg1	conductance					1131:1141	canopy conductance	1124:1141	canopy conductance	1124:1141	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	0	28	theme	Temperature-sensitive	0:20	arg1	O-fractionation					37:51	Temperature-sensitive biochemical 18 O-fractionation	0:51	Temperature-sensitive biochemical 18 O-fractionation	0:51	Temperature-sensitive biochemical 18 O-fractionation and humidity-dependent attenuation factor are needed to predict δ18 O of cellulose from leaf water in a grassland ecosystem.
33251585	1	29	theme	isotope	299:305	arg1	composition					307:317	the oxygen isotope composition	288:317	the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem	288:403	We explore here our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem.
33251585	1	30	from	composition	307:317	arg1	ecosystem					395:403	a drought-prone, temperate grassland ecosystem	358:403	a drought-prone, temperate grassland ecosystem	358:403	We explore here our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem.
33251585	5	31	theme	leaf	1457:1460	arg1	O-enrichment					1471:1482	leaf water 18 O-enrichment	1457:1482	leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63)	1457:1513	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	31	theme	leaf	1457:1460	arg1	px					1493:1494	1 - pex px	1485:1494	1 - pex px	1485:1494	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	32	theme	1 - pex	1485:1491	arg1	O-enrichment					1471:1482	leaf water 18 O-enrichment	1457:1482	leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63)	1457:1513	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	32	theme	1 - pex	1485:1491	arg1	px					1493:1494	1 - pex px	1485:1494	1 - pex px	1485:1494	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	6	33	from	knowledge	1699:1707	arg1	εbio					1743:1746	εbio	1743:1746	εbio	1743:1746	Understanding physiological information in δ18 Ocellulose requires quantitative knowledge of climatic effects on pex px and εbio .
33251585	6	33	from	knowledge	1699:1707	arg1	px					1736:1737	pex px	1732:1737	pex px	1732:1737	Understanding physiological information in δ18 Ocellulose requires quantitative knowledge of climatic effects on pex px and εbio .
33251585	1	34	dep	drought-prone	360:372	arg1	temperate					375:383	temperate	375:383	temperate	375:383	We explore here our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem.
33251585	0	35	theme	leaf	141:144	arg1	water					146:150	leaf water	141:150	leaf water	141:150	Temperature-sensitive biochemical 18 O-fractionation and humidity-dependent attenuation factor are needed to predict δ18 O of cellulose from leaf water in a grassland ecosystem.
33251585	1	36	theme	mechanistic	198:208	arg1	understanding					210:222	our mechanistic understanding	194:222	our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem	194:403	We explore here our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem.
33251585	6	37	theme	quantitative	1686:1697	arg1	knowledge					1699:1707	quantitative knowledge	1686:1707	quantitative knowledge of climatic effects on pex px and εbio	1686:1746	Understanding physiological information in δ18 Ocellulose requires quantitative knowledge of climatic effects on pex px and εbio .
33251585	2	38	theme	multi-annual	573:584	arg1	variation					598:606	seasonal (April-October) and multi-annual (2007-2012) variation	544:606	variation	598:606	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	0	39	theme	humidity-dependent	57:74	arg1	factor					88:93	humidity-dependent attenuation factor	57:93	humidity-dependent attenuation factor	57:93	Temperature-sensitive biochemical 18 O-fractionation and humidity-dependent attenuation factor are needed to predict δ18 O of cellulose from leaf water in a grassland ecosystem.
33251585	1	40	theme	leaf	322:325	arg1	cellulose					327:335	leaf cellulose	322:335	leaf cellulose (δ18 Ocellulose )	322:353	We explore here our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem.
33251585	1	40	theme	leaf	322:325	arg1	Ocellulose					342:351	δ18 Ocellulose	338:351	δ18 Ocellulose	338:351	We explore here our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem.
33251585	4	41	theme	midday	950:955	arg1	humidity					966:973	midday relative humidity	950:973	midday relative humidity	950:973	Over the integration time, air temperature ranged from 7 to 22°C and midday relative humidity from 47 to 73%.
33251585	5	42	theme	Ocellulose	1063:1072	arg1	observations					1012:1023	observations	1012:1023	observations	1012:1023	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	42	theme	Ocellulose	1063:1072	arg1	relationship					1106:1117	their negative relationship	1091:1117	their negative relationship	1091:1117	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	43	theme	air	1532:1534	arg1	humidity					1545:1552	air relative humidity	1532:1552	air relative humidity	1532:1552	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	2	44	theme	transfer	509:516	arg1	MuSICA					525:530	MuSICA	525:530	MuSICA	525:530	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	2	44	theme	transfer	509:516	arg1	model					518:522	an 18 O-enabled soil-vegetation-atmosphere transfer model	466:522	an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA)	466:531	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	1	45	theme	cellulose	327:335	arg1	composition					307:317	the oxygen isotope composition	288:317	the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem	288:403	We explore here our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem.
33251585	5	46	theme	relative	1536:1543	arg1	humidity					1545:1552	air relative humidity	1532:1552	air relative humidity	1532:1552	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	6	47	theme	climatic	1712:1719	arg1	effects					1721:1727	climatic effects	1712:1727	climatic effects on pex px and εbio	1712:1746	Understanding physiological information in δ18 Ocellulose requires quantitative knowledge of climatic effects on pex px and εbio .
33251585	5	48	theme	grown	1381:1385	arg1	seedlings					1393:1401	heterotrophically grown wheat seedlings	1363:1401	heterotrophically grown wheat seedlings	1363:1401	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	49	dep	px	1493:1494	arg1	range					1498:1502	range 0.23-0.63	1498:1512	range 0.23-0.63	1498:1512	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	2	50	theme	soil-vegetation-atmosphere	482:507	arg1	MuSICA					525:530	MuSICA	525:530	MuSICA	525:530	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	2	50	theme	soil-vegetation-atmosphere	482:507	arg1	model					518:522	an 18 O-enabled soil-vegetation-atmosphere transfer model	466:522	an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA)	466:531	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	3	51	theme	similar	822:828	arg1	growing-degree-days					801:819	c. 400 growing-degree-days	794:819	c. 400 growing-degree-days	794:819	Modelled δ18 Ocellulose agreed best with observations when integrated over c. 400 growing-degree-days, similar to the average leaf lifespan observed at the site.
33251585	0	52	theme	grassland	157:165	arg1	ecosystem					167:175	a grassland ecosystem	155:175	a grassland ecosystem	155:175	Temperature-sensitive biochemical 18 O-fractionation and humidity-dependent attenuation factor are needed to predict δ18 O of cellulose from leaf water in a grassland ecosystem.
33251585	5	53	theme	R2	1075:1076	arg1	Ocellulose					1063:1072	Δ18 Ocellulose	1059:1072	Δ18 Ocellulose (R2 = 0.74)	1059:1084	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	53	theme	R2	1075:1076	arg1	= 0.74					1078:1083	R2 = 0.74	1075:1083	R2 = 0.74	1075:1083	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	54	theme	Ocellulose	1032:1041	arg1	observations					1012:1023	observations	1012:1023	observations	1012:1023	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	54	theme	Ocellulose	1032:1041	arg1	relationship					1106:1117	their negative relationship	1091:1117	their negative relationship	1091:1117	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	55	theme	wheat	1387:1391	arg1	seedlings					1393:1401	heterotrophically grown wheat seedlings	1363:1401	heterotrophically grown wheat seedlings	1363:1401	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	56	from	proportion	1412:1421	arg1	cellulose					1436:1444	cellulose	1436:1444	cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63)	1436:1513	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	0	57	theme	attenuation	76:86	arg1	factor					88:93	humidity-dependent attenuation factor	57:93	humidity-dependent attenuation factor	57:93	Temperature-sensitive biochemical 18 O-fractionation and humidity-dependent attenuation factor are needed to predict δ18 O of cellulose from leaf water in a grassland ecosystem.
33251585	5	58	theme	R2	1044:1045	arg1	Ocellulose					1032:1041	δ18 Ocellulose	1028:1041	δ18 Ocellulose (R2 = 0.57)	1028:1053	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	58	theme	R2	1044:1045	arg1	= 0.57					1047:1052	R2 = 0.57	1044:1052	R2 = 0.57	1044:1052	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	59	theme	water	1462:1466	arg1	O-enrichment					1471:1482	leaf water 18 O-enrichment	1457:1482	leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63)	1457:1513	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	59	theme	water	1462:1466	arg1	px					1493:1494	1 - pex px	1485:1494	1 - pex px	1485:1494	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	60	theme	canopy	1124:1129	arg1	conductance					1131:1141	canopy conductance	1124:1141	canopy conductance	1124:1141	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	3	61	located	observed	859:866	arg1	site					875:878	the site	871:878	the site	871:878	Modelled δ18 Ocellulose agreed best with observations when integrated over c. 400 growing-degree-days, similar to the average leaf lifespan observed at the site.
33251585	3	61	located	observed	859:866	arg2	lifespan					850:857	the average leaf lifespan	833:857	the average leaf lifespan observed at the site	833:878	Modelled δ18 Ocellulose agreed best with observations when integrated over c. 400 growing-degree-days, similar to the average leaf lifespan observed at the site.
33251585	4	62	dep	73	986:987	arg1	to					983:984	to	983:984	to	983:984	Over the integration time, air temperature ranged from 7 to 22°C and midday relative humidity from 47 to 73%.
33251585	6	63	theme	effects	1721:1727	arg1	knowledge					1699:1707	quantitative knowledge	1686:1707	quantitative knowledge of climatic effects on pex px and εbio	1686:1746	Understanding physiological information in δ18 Ocellulose requires quantitative knowledge of climatic effects on pex px and εbio .
33251585	5	64	theme	Model	991:995	arg1	agreement					997:1005	Model agreement	991:1005	Model agreement	991:1005	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	1	65	theme	environmental	231:243	arg1	processes					263:271	the environmental and physiological processes	227:271	the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem	227:403	We explore here our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem.
33251585	2	66	theme	2007-2012	587:595	arg1	variation					598:606	seasonal (April-October) and multi-annual (2007-2012) variation	544:606	variation	598:606	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	5	67	with	experiments	1593:1603	arg1	grasses					1610:1616	grasses	1610:1616	grasses	1610:1616	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	68	theme	aquatic	1344:1350	arg1	plants					1352:1357	aquatic plants	1344:1357	aquatic plants	1344:1357	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	4	69	theme	relative	957:964	arg1	humidity					966:973	midday relative humidity	950:973	midday relative humidity	950:973	Over the integration time, air temperature ranged from 7 to 22°C and midday relative humidity from 47 to 73%.
33251585	0	70	from	water	146:150	arg1	O					121:121	δ18 O	117:121	δ18 O of cellulose from leaf water	117:150	Temperature-sensitive biochemical 18 O-fractionation and humidity-dependent attenuation factor are needed to predict δ18 O of cellulose from leaf water in a grassland ecosystem.
33251585	5	71	from	cellulose	1436:1444	arg1	proportion					1412:1421	the proportion	1408:1421	the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63)	1408:1513	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	5	71	from	cellulose	1436:1444	arg1	dependent					1519:1527	dependent	1519:1527	dependent	1519:1527	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	2	72	theme	new	408:410	arg1	model					434:438	A new allocation-and-growth model	406:438	A new allocation-and-growth model	406:438	A new allocation-and-growth model was designed and added to an 18 O-enabled soil-vegetation-atmosphere transfer model (MuSICA) to predict seasonal (April-October) and multi-annual (2007-2012) variation of δ18 Ocellulose and 18 O-enrichment of leaf cellulose (Δ18 Ocellulose ) based on the Barbour-Farquhar model.
33251585	1	73	theme	physiological	249:261	arg1	processes					263:271	the environmental and physiological processes	227:271	the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem	227:403	We explore here our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem.
33251585	5	74	theme	independent	1570:1580	arg1	experiments					1593:1603	independent controlled experiments	1570:1603	independent controlled experiments with grasses	1570:1616	Model agreement with observations of δ18 Ocellulose (R2 = 0.57) and Δ18 Ocellulose (R2 = 0.74), and their negative relationship with canopy conductance, was improved significantly when both the biochemical 18 O-fractionation between water and substrate for cellulose synthesis (εbio , range 26-30‰) was temperature-sensitive, as previously reported for aquatic plants and heterotrophically grown wheat seedlings, and the proportion of oxygen in cellulose reflecting leaf water 18 O-enrichment (1 - pex px , range 0.23-0.63) was dependent on air relative humidity, as observed in independent controlled experiments with grasses.
33251585	3	75	theme	Modelled	719:726	arg1	Ocellulose					732:741	Modelled δ18 Ocellulose	719:741	Modelled δ18 Ocellulose	719:741	Modelled δ18 Ocellulose agreed best with observations when integrated over c. 400 growing-degree-days, similar to the average leaf lifespan observed at the site.
33251585	6	76	from	effects	1721:1727	arg1	εbio					1743:1746	εbio	1743:1746	εbio	1743:1746	Understanding physiological information in δ18 Ocellulose requires quantitative knowledge of climatic effects on pex px and εbio .
33251585	6	76	from	effects	1721:1727	arg1	px					1736:1737	pex px	1732:1737	pex px	1732:1737	Understanding physiological information in δ18 Ocellulose requires quantitative knowledge of climatic effects on pex px and εbio .
33251585	3	77	theme	average	837:843	arg1	lifespan					850:857	the average leaf lifespan	833:857	the average leaf lifespan observed at the site	833:878	Modelled δ18 Ocellulose agreed best with observations when integrated over c. 400 growing-degree-days, similar to the average leaf lifespan observed at the site.
33251585	4	78	theme	air	908:910	arg1	temperature					912:922	air temperature	908:922	air temperature	908:922	Over the integration time, air temperature ranged from 7 to 22°C and midday relative humidity from 47 to 73%.
33251585	1	79	theme	processes	263:271	arg1	understanding					210:222	our mechanistic understanding	194:222	our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem	194:403	We explore here our mechanistic understanding of the environmental and physiological processes that determine the oxygen isotope composition of leaf cellulose (δ18 Ocellulose ) in a drought-prone, temperate grassland ecosystem.
33535152	0	0	theme	peroxyformic	89:100	arg1	acid					102:105	peroxyformic acid	89:105	peroxyformic acid	89:105	Enhanced enzymatic hydrolysis and hydrogen production of sugarcane bagasse pretreated by peroxyformic acid.
33535152	2	1	theme	sugarcane	354:362	arg1	SCB					373:375	SCB	373:375	SCB	373:375	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	2	1	theme	sugarcane	354:362	arg1	bagasse					364:370	pretreated sugarcane bagasse	343:370	pretreated sugarcane bagasse (SCB)	343:376	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	4	2	with	production	761:770	arg1	MC1					833:835	an enriched anaerobic cellulolytic microbial consortium MC1	777:835	an enriched anaerobic cellulolytic microbial consortium MC1	777:835	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	1	3	theme	lignocellulosic	165:179	arg1	biomass					181:187	lignocellulosic biomass	165:187	lignocellulosic biomass	165:187	Pretreatment plays a key role in biofuel production from lignocellulosic biomass.
33535152	2	4	theme	pretreated	343:352	arg1	SCB					373:375	SCB	373:375	SCB	373:375	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	2	4	theme	pretreated	343:352	arg1	bagasse					364:370	pretreated sugarcane bagasse	343:370	pretreated sugarcane bagasse (SCB)	343:376	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	4	5	theme	pretreated	697:706	arg1	SCB					708:710	pretreated SCB	697:710	pretreated SCB	697:710	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	5	6	dep	%	1017:1017	arg1	to					1010:1011	to	1010:1011	to	1010:1011	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	5	7	from	hemicellulose	1055:1067	arg1	SCB					1086:1088	PA pretreated SCB	1072:1088	PA pretreated SCB	1072:1088	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	3	8	theme	slight	508:513	arg1	loss					525:528	slight cellulose loss	508:528	slight cellulose loss (9.2%)	508:535	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	3	8	theme	slight	508:513	arg1	%					534:534	9.2%	531:534	9.2%	531:534	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	4	9	theme	SCB	650:652	arg1	characteristics					631:645	the structural characteristics	616:645	the structural characteristics of SCB	616:652	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	5	10	theme	PA	1072:1073	arg1	SCB					1086:1088	PA pretreated SCB	1072:1088	PA pretreated SCB	1072:1088	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	4	11	theme	microbial	812:820	arg1	consortium					822:831	an enriched anaerobic cellulolytic microbial consortium	777:831	an enriched anaerobic cellulolytic microbial consortium MC1	777:835	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	3	12	theme	pretreated	488:497	arg1	SCB					499:501	the pretreated SCB	484:501	the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions	484:579	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	5	13	theme	hydrogen	842:849	arg1	production					851:860	The hydrogen production	838:860	The hydrogen production	838:860	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	5	14	theme	pretreated	1075:1084	arg1	SCB					1086:1088	PA pretreated SCB	1072:1088	PA pretreated SCB	1072:1088	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	4	15	theme	cellulolytic	799:810	arg1	consortium					822:831	an enriched anaerobic cellulolytic microbial consortium	777:831	an enriched anaerobic cellulolytic microbial consortium MC1	777:835	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	5	16	theme	hemicellulose-degradation	935:959	arg1	abundance					913:921	the abundance	909:921	the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium	909:987	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	4	17	theme	pretreatment	600:611	arg1	effects					586:592	The effects	582:592	The effects of PA pretreatment on the structural characteristics of SCB	582:652	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	0	18	theme	enzymatic	9:17	arg1	hydrolysis					19:28	Enhanced enzymatic hydrolysis	0:28	Enhanced enzymatic hydrolysis	0:28	Enhanced enzymatic hydrolysis and hydrogen production of sugarcane bagasse pretreated by peroxyformic acid.
33535152	3	19	dep	removed	404:410	arg1	%					417:417	59.0%	413:417	59.0%	413:417	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	4	20	theme	structural	620:629	arg1	characteristics					631:645	the structural characteristics	616:645	the structural characteristics of SCB	616:652	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	0	21	theme	Enhanced	0:7	arg1	hydrolysis					19:28	Enhanced enzymatic hydrolysis	0:28	Enhanced enzymatic hydrolysis	0:28	Enhanced enzymatic hydrolysis and hydrogen production of sugarcane bagasse pretreated by peroxyformic acid.
33535152	4	22	theme	consortium	822:831	arg1	MC1					833:835	an enriched anaerobic cellulolytic microbial consortium MC1	777:835	an enriched anaerobic cellulolytic microbial consortium MC1	777:835	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	2	23	theme	enzymolysis	292:302	arg1	efficiency					304:313	enzymolysis efficiency	292:313	enzymolysis efficiency	292:313	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	3	24	theme	cellulose	515:523	arg1	loss					525:528	slight cellulose loss	508:528	slight cellulose loss (9.2%)	508:535	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	3	24	theme	cellulose	515:523	arg1	%					534:534	9.2%	531:534	9.2%	531:534	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	3	25	theme	saccharification	435:450	arg1	%					464:464	103.6%	459:464	103.6%	459:464	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	3	25	theme	saccharification	435:450	arg1	level					452:456	a complete saccharification level	424:456	a complete saccharification level (103.6%)	424:465	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	5	26	theme	dominant	926:933	arg1	hemicellulose-degradation					935:959	dominant hemicellulose-degradation genus Thermoanaerobacterium	926:987	dominant hemicellulose-degradation genus Thermoanaerobacterium	926:987	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	5	27	theme	remaining	1030:1038	arg1	hemicellulose					1055:1067	the remaining and accessible hemicellulose	1026:1067	the remaining and accessible hemicellulose in PA pretreated SCB	1026:1088	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	0	28	dep	bagasse	67:73	arg1	pretreated					75:84	pretreated	75:84	bagasse pretreated by peroxyformic acid	67:105	Enhanced enzymatic hydrolysis and hydrogen production of sugarcane bagasse pretreated by peroxyformic acid.
33535152	4	29	from	effects	586:592	arg1	characteristics					631:645	the structural characteristics	616:645	the structural characteristics of SCB	616:652	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	5	30	dep	hemicellulose-degradation	935:959	arg1	Thermoanaerobacterium					967:987	dominant hemicellulose-degradation genus Thermoanaerobacterium	926:987	dominant hemicellulose-degradation genus Thermoanaerobacterium	926:987	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	2	31	theme	acid	238:241	arg1	pretreatment					248:259	peroxyformic acid (PA) pretreatment	225:259	peroxyformic acid (PA) pretreatment	225:259	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	4	32	theme	PA	597:598	arg1	pretreatment					600:611	PA pretreatment	597:611	PA pretreatment	597:611	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	0	33	theme	hydrogen	34:41	arg1	production					43:52	hydrogen production	34:52	hydrogen production of sugarcane	34:65	Enhanced enzymatic hydrolysis and hydrogen production of sugarcane bagasse pretreated by peroxyformic acid.
33535152	3	34	with	SCB	499:501	arg1	loss					525:528	slight cellulose loss	508:528	slight cellulose loss (9.2%)	508:535	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	3	34	with	SCB	499:501	arg1	%					534:534	9.2%	531:534	9.2%	531:534	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	5	35	theme	accessible	1044:1053	arg1	hemicellulose					1055:1067	the remaining and accessible hemicellulose	1026:1067	the remaining and accessible hemicellulose in PA pretreated SCB	1026:1088	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	2	36	theme	peroxyformic	225:236	arg1	PA					244:245	PA	244:245	PA	244:245	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	2	36	theme	peroxyformic	225:236	arg1	acid					238:241	peroxyformic acid	225:241	peroxyformic acid (PA) pretreatment	225:259	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	3	37	theme	complete	426:433	arg1	%					464:464	103.6%	459:464	103.6%	459:464	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	3	37	theme	complete	426:433	arg1	level					452:456	a complete saccharification level	424:456	a complete saccharification level (103.6%)	424:465	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	0	38	theme	sugarcane	57:65	arg1	hydrolysis					19:28	Enhanced enzymatic hydrolysis	0:28	Enhanced enzymatic hydrolysis	0:28	Enhanced enzymatic hydrolysis and hydrogen production of sugarcane bagasse pretreated by peroxyformic acid.
33535152	0	38	theme	sugarcane	57:65	arg1	production					43:52	hydrogen production	34:52	hydrogen production of sugarcane	34:65	Enhanced enzymatic hydrolysis and hydrogen production of sugarcane bagasse pretreated by peroxyformic acid.
33535152	5	39	theme	due	1019:1021	arg1	%					1017:1017	23.8% to 40.2%	1004:1017	23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB	1004:1088	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	4	40	theme	anaerobic	789:797	arg1	consortium					822:831	an enriched anaerobic cellulolytic microbial consortium	777:831	an enriched anaerobic cellulolytic microbial consortium MC1	777:835	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	2	41	theme	main	209:212	arg1	factors					214:220	the main factors	205:220	the main factors of peroxyformic acid (PA) pretreatment	205:259	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	4	42	theme	enriched	780:787	arg1	consortium					822:831	an enriched anaerobic cellulolytic microbial consortium	777:831	an enriched anaerobic cellulolytic microbial consortium MC1	777:835	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	1	43	theme	key	129:131	arg1	role					133:136	a key role	127:136	a key role	127:136	Pretreatment plays a key role in biofuel production from lignocellulosic biomass.
33535152	4	44	theme	hydrogen	752:759	arg1	production					761:770	dark fermentative hydrogen production	734:770	dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1	734:835	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	4	45	theme	fermentative	739:750	arg1	production					761:770	dark fermentative hydrogen production	734:770	dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1	734:835	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	2	46	theme	pretreatment	248:259	arg1	factors					214:220	the main factors	205:220	the main factors of peroxyformic acid (PA) pretreatment	205:259	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	5	47	theme	%	1008:1008	arg1	%					1017:1017	23.8% to 40.2%	1004:1017	23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB	1004:1088	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	2	48	theme	composition	319:329	arg1	analysis					331:338	composition analysis	319:338	composition analysis of pretreated sugarcane bagasse (SCB)	319:376	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	4	49	theme	SCB	708:710	arg1	digestibility					680:692	the digestibility	676:692	the digestibility of pretreated SCB	676:710	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	4	50	theme	dark	734:737	arg1	production					761:770	dark fermentative hydrogen production	734:770	dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1	734:835	The effects of PA pretreatment on the structural characteristics of SCB were also studied and the digestibility of pretreated SCB was also evaluated by dark fermentative hydrogen production with an enriched anaerobic cellulolytic microbial consortium MC1.
33535152	5	51	theme	initial	892:898	arg1	SCB					900:902	initial SCB	892:902	initial SCB	892:902	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	2	52	dep	efficiency	304:313	arg1	the					279:281	the	279:281	the	279:281	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	2	52	dep	efficiency	304:313	arg1	light					283:287	light	283:287	light	283:287	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	3	53	theme	optimized	547:555	arg1	conditions					570:579	the optimized pretreatment conditions	543:579	the optimized pretreatment conditions	543:579	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	1	54	theme	biofuel	141:147	arg1	production					149:158	biofuel production	141:158	biofuel production from lignocellulosic biomass	141:187	Pretreatment plays a key role in biofuel production from lignocellulosic biomass.
33535152	5	55	theme	genus	961:965	arg1	hemicellulose-degradation					935:959	dominant hemicellulose-degradation genus Thermoanaerobacterium	926:987	dominant hemicellulose-degradation genus Thermoanaerobacterium	926:987	The hydrogen production increased by 195.5% (based on initial SCB) and the abundance of dominant hemicellulose-degradation genus Thermoanaerobacterium increased from 23.8% to 40.2% due to the remaining and accessible hemicellulose in PA pretreated SCB.
33535152	3	56	theme	pretreatment	557:568	arg1	conditions					570:579	the optimized pretreatment conditions	543:579	the optimized pretreatment conditions	543:579	Lignin was significantly removed (59.0%) and a complete saccharification level (103.6%) was obtained for the pretreated SCB with slight cellulose loss (9.2%) under the optimized pretreatment conditions.
33535152	1	57	from	biomass	181:187	arg1	production					149:158	biofuel production	141:158	biofuel production from lignocellulosic biomass	141:187	Pretreatment plays a key role in biofuel production from lignocellulosic biomass.
33535152	2	58	theme	bagasse	364:370	arg1	analysis					331:338	composition analysis	319:338	composition analysis of pretreated sugarcane bagasse (SCB)	319:376	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33535152	2	58	theme	bagasse	364:370	arg1	efficiency					304:313	enzymolysis efficiency	292:313	enzymolysis efficiency	292:313	In this study, the main factors of peroxyformic acid (PA) pretreatment were optimized in the light of enzymolysis efficiency and composition analysis of pretreated sugarcane bagasse (SCB).
33493560	0	0	theme	real	153:156	arg1	water					158:162	real water	153:162	real water	153:162	Insight into chitosan/mesoporous silica nanocomposites as eco-friendly adsorbent for enhanced retention of U (VI) and Sr (II) from aqueous solutions and real water.
33493560	4	1	theme	Pseudo-First	690:701	arg1	model					709:713	the Pseudo-First order model	686:713	the Pseudo-First order model	686:713	The composite showed the kinetic behavior of the Pseudo-First order model and the isotherm properties of the Langmuir assumption.
33493560	0	2	from	solutions	139:147	arg1	retention					94:102	enhanced retention	85:102	enhanced retention of U (VI) and Sr (II) from aqueous solutions	85:147	Insight into chitosan/mesoporous silica nanocomposites as eco-friendly adsorbent for enhanced retention of U (VI) and Sr (II) from aqueous solutions and real water.
33493560	0	2	from	solutions	139:147	arg1	water					158:162	real water	153:162	real water	153:162	Insight into chitosan/mesoporous silica nanocomposites as eco-friendly adsorbent for enhanced retention of U (VI) and Sr (II) from aqueous solutions and real water.
33493560	6	3	dep	5.77 kJ mol-1	1089:1101	arg1	U					1104:1104	U	1104:1104	U	1104:1104	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	7	4	theme	other	1356:1360	arg1	Zn					1392:1393	Zn (II)	1392:1398	Zn (II)	1392:1398	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	4	theme	other	1356:1360	arg1	Pb					1383:1384	Pb (II)	1383:1389	Pb (II)	1383:1389	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	4	theme	other	1356:1360	arg1	Cd					1374:1375	Cd (II)	1374:1380	Cd (II)	1374:1380	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	4	theme	other	1356:1360	arg1	Co					1405:1406	Co (II)	1405:1411	Co (II)	1405:1411	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	4	theme	other	1356:1360	arg1	ions					1368:1371	other metal ions	1356:1371	other metal ions (Cd (II), Pb (II), Zn (II), and Co (II))	1356:1412	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	6	5	theme	free	1031:1034	arg1	energy					1036:1041	Gibbs free energy	1025:1041	Gibbs free energy (less than 20 kJ mol-1)	1025:1065	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	4	6	theme	Langmuir	750:757	arg1	assumption					759:768	the Langmuir assumption	746:768	the Langmuir assumption	746:768	The composite showed the kinetic behavior of the Pseudo-First order model and the isotherm properties of the Langmuir assumption.
33493560	3	7	theme	promising	481:489	arg1	capacities					501:510	promising retention capacities	481:510	promising retention capacities of 261.3 mg/g and 328.6 mg/g for U (VI) and Sr (II)	481:562	It displayed promising retention capacities of 261.3 mg/g and 328.6 mg/g for U (VI) and Sr (II) considering the equilibrium time interval that was identified after 420 min.
33493560	6	8	dep	entropy	961:967	arg1	Sr					1014:1015	Sr (II)	1014:1020	Sr (II)	1014:1020	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	6	8	dep	entropy	961:967	arg1	-2.93 kJ mol-1					998:1011	-2.93 kJ mol-1	998:1011	-2.93 kJ mol-1 (Sr (II))	998:1021	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	6	8	dep	entropy	961:967	arg1	-5.94 kJ mol-1					970:983	-5.94 kJ mol-1	970:983	-5.94 kJ mol-1 (U (VI))	970:992	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	0	9	theme	U	107:107	arg1	retention					94:102	enhanced retention	85:102	enhanced retention of U (VI) and Sr (II) from aqueous solutions	85:147	Insight into chitosan/mesoporous silica nanocomposites as eco-friendly adsorbent for enhanced retention of U (VI) and Sr (II) from aqueous solutions and real water.
33493560	0	9	theme	U	107:107	arg1	water					158:162	real water	153:162	real water	153:162	Insight into chitosan/mesoporous silica nanocomposites as eco-friendly adsorbent for enhanced retention of U (VI) and Sr (II) from aqueous solutions and real water.
33493560	5	10	dep	U	849:849	arg1	VI					852:853	VI	852:853	VI	852:853	The thermodynamic assessment of the reactions validated the retention of both U (VI) and Sr (II) ions by spontaneous, favorable, and exothermic reactions.
33493560	6	11	theme	energy	1081:1086	arg1	values					951:956	the theoretical values	935:956	the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II)))	935:1139	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	3	12	theme	retention	491:499	arg1	capacities					501:510	promising retention capacities	481:510	promising retention capacities of 261.3 mg/g and 328.6 mg/g for U (VI) and Sr (II)	481:562	It displayed promising retention capacities of 261.3 mg/g and 328.6 mg/g for U (VI) and Sr (II) considering the equilibrium time interval that was identified after 420 min.
33493560	1	13	theme	eco-friendly	237:248	arg1	CH/MCM-48					261:269	CH/MCM-48	261:269	CH/MCM-48	261:269	The chitosan chains were integrated with MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity.
33493560	1	13	theme	eco-friendly	237:248	arg1	composite					250:258	an eco-friendly composite	234:258	an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity	234:302	The chitosan chains were integrated with MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity.
33493560	1	13	theme	eco-friendly	237:248	arg1	capacity					295:302	enhanced adsorption capacity	275:302	enhanced adsorption capacity	275:302	The chitosan chains were integrated with MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity.
33493560	2	14	theme	radioactive	444:454	arg1	pollutants					456:465	the commonly detected radioactive pollutants	422:465	the commonly detected radioactive pollutants	422:465	The prepared CH/MCM-48 composite was applied in systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants.
33493560	6	15	theme	Gaussian	1072:1079	arg1	energy					1081:1086	Gaussian energy	1072:1086	Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II)))	1072:1139	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	4	16	theme	order	703:707	arg1	model					709:713	the Pseudo-First order model	686:713	the Pseudo-First order model	686:713	The composite showed the kinetic behavior of the Pseudo-First order model and the isotherm properties of the Langmuir assumption.
33493560	2	17	theme	U	377:377	arg1	retention					364:372	systematic retention	353:372	systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants	353:465	The prepared CH/MCM-48 composite was applied in systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants.
33493560	2	18	theme	detected	435:442	arg1	pollutants					456:465	the commonly detected radioactive pollutants	422:465	the commonly detected radioactive pollutants	422:465	The prepared CH/MCM-48 composite was applied in systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants.
33493560	4	19	theme	assumption	759:768	arg1	behavior					674:681	the kinetic behavior	662:681	the kinetic behavior of the Pseudo-First order model	662:713	The composite showed the kinetic behavior of the Pseudo-First order model and the isotherm properties of the Langmuir assumption.
33493560	4	19	theme	assumption	759:768	arg1	properties					732:741	the isotherm properties	719:741	the isotherm properties of the Langmuir assumption	719:768	The composite showed the kinetic behavior of the Pseudo-First order model and the isotherm properties of the Langmuir assumption.
33493560	0	20	dep	U	107:107	arg1	VI					110:111	VI	110:111	VI	110:111	Insight into chitosan/mesoporous silica nanocomposites as eco-friendly adsorbent for enhanced retention of U (VI) and Sr (II) from aqueous solutions and real water.
33493560	6	21	theme	entropy	961:967	arg1	values					951:956	the theoretical values	935:956	the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II)))	935:1139	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	7	22	theme	CH/MCM-48	1212:1220	arg1	composite					1222:1230	The CH/MCM-48 composite	1208:1230	The CH/MCM-48 composite	1208:1230	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	5	23	theme	favorable	889:897	arg1	reactions					915:923	spontaneous, favorable, and exothermic reactions	876:923	spontaneous, favorable, and exothermic reactions	876:923	The thermodynamic assessment of the reactions validated the retention of both U (VI) and Sr (II) ions by spontaneous, favorable, and exothermic reactions.
33493560	3	24	theme	261.3 mg/g	515:524	arg1	capacities					501:510	promising retention capacities	481:510	promising retention capacities of 261.3 mg/g and 328.6 mg/g for U (VI) and Sr (II)	481:562	It displayed promising retention capacities of 261.3 mg/g and 328.6 mg/g for U (VI) and Sr (II) considering the equilibrium time interval that was identified after 420 min.
33493560	3	25	dep	U	545:545	arg1	VI					548:549	VI	548:549	VI	548:549	It displayed promising retention capacities of 261.3 mg/g and 328.6 mg/g for U (VI) and Sr (II) considering the equilibrium time interval that was identified after 420 min.
33493560	2	26	theme	Sr	395:396	arg1	ions					403:406	Sr (II) ions	395:406	U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants	377:465	The prepared CH/MCM-48 composite was applied in systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants.
33493560	6	27	theme	Gibbs	1025:1029	arg1	energy					1036:1041	Gibbs free energy	1025:1041	Gibbs free energy (less than 20 kJ mol-1)	1025:1065	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	7	28	theme	considerable	1275:1286	arg1	affinities					1288:1297	considerable affinities	1275:1297	considerable affinities for the studied radioactive ions	1275:1330	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	2	29	theme	systematic	353:362	arg1	retention					364:372	systematic retention	353:372	systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants	353:465	The prepared CH/MCM-48 composite was applied in systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants.
33493560	6	30	theme	adsorption	1186:1195	arg1	reactions					1197:1205	physical adsorption reactions	1177:1205	physical adsorption reactions	1177:1205	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	4	31	theme	isotherm	723:730	arg1	properties					732:741	the isotherm properties	719:741	the isotherm properties of the Langmuir assumption	719:768	The composite showed the kinetic behavior of the Pseudo-First order model and the isotherm properties of the Langmuir assumption.
33493560	0	32	theme	Sr	118:119	arg1	retention					94:102	enhanced retention	85:102	enhanced retention of U (VI) and Sr (II) from aqueous solutions	85:147	Insight into chitosan/mesoporous silica nanocomposites as eco-friendly adsorbent for enhanced retention of U (VI) and Sr (II) from aqueous solutions and real water.
33493560	0	32	theme	Sr	118:119	arg1	water					158:162	real water	153:162	real water	153:162	Insight into chitosan/mesoporous silica nanocomposites as eco-friendly adsorbent for enhanced retention of U (VI) and Sr (II) from aqueous solutions and real water.
33493560	5	33	theme	Sr	860:861	arg1	ions					868:871	Sr (II) ions	860:871	Sr (II) ions	860:871	The thermodynamic assessment of the reactions validated the retention of both U (VI) and Sr (II) ions by spontaneous, favorable, and exothermic reactions.
33493560	6	34	dep	U	1104:1104	arg1	VI					1107:1108	VI	1107:1108	VI	1107:1108	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	5	35	theme	II	864:865	arg1	ions					868:871	Sr (II) ions	860:871	Sr (II) ions	860:871	The thermodynamic assessment of the reactions validated the retention of both U (VI) and Sr (II) ions by spontaneous, favorable, and exothermic reactions.
33493560	0	36	theme	chitosan/mesoporous	13:31	arg1	silica					33:38	chitosan/mesoporous silica	13:38	chitosan/mesoporous silica	13:38	Insight into chitosan/mesoporous silica nanocomposites as eco-friendly adsorbent for enhanced retention of U (VI) and Sr (II) from aqueous solutions and real water.
33493560	5	37	theme	ions	868:871	arg1	retention					831:839	the retention	827:839	the retention of both U (VI) and Sr (II) ions	827:871	The thermodynamic assessment of the reactions validated the retention of both U (VI) and Sr (II) ions by spontaneous, favorable, and exothermic reactions.
33493560	7	38	theme	radioactive	1315:1325	arg1	ions					1327:1330	the studied radioactive ions	1303:1330	the studied radioactive ions	1303:1330	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	4	39	theme	kinetic	666:672	arg1	behavior					674:681	the kinetic behavior	662:681	the kinetic behavior of the Pseudo-First order model	662:713	The composite showed the kinetic behavior of the Pseudo-First order model and the isotherm properties of the Langmuir assumption.
33493560	1	40	theme	chitosan	169:176	arg1	chains					178:183	The chitosan chains	165:183	The chitosan chains	165:183	The chitosan chains were integrated with MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity.
33493560	5	41	theme	U	849:849	arg1	retention					831:839	the retention	827:839	the retention of both U (VI) and Sr (II) ions	827:871	The thermodynamic assessment of the reactions validated the retention of both U (VI) and Sr (II) ions by spontaneous, favorable, and exothermic reactions.
33493560	1	42	from	silica	224:229	arg1	CH/MCM-48					261:269	CH/MCM-48	261:269	CH/MCM-48	261:269	The chitosan chains were integrated with MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity.
33493560	1	42	from	silica	224:229	arg1	composite					250:258	an eco-friendly composite	234:258	an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity	234:302	The chitosan chains were integrated with MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity.
33493560	1	42	from	silica	224:229	arg1	capacity					295:302	enhanced adsorption capacity	275:302	enhanced adsorption capacity	275:302	The chitosan chains were integrated with MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity.
33493560	2	43	from	water	413:417	arg1	U					377:377	U	377:377	U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants	377:465	The prepared CH/MCM-48 composite was applied in systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants.
33493560	2	43	from	water	413:417	arg1	ions					403:406	Sr (II) ions	395:406	U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants	377:465	The prepared CH/MCM-48 composite was applied in systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants.
33493560	2	43	from	water	413:417	arg1	retention					364:372	systematic retention	353:372	systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants	353:465	The prepared CH/MCM-48 composite was applied in systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants.
33493560	5	44	theme	reactions	807:815	arg1	assessment					789:798	The thermodynamic assessment	771:798	The thermodynamic assessment of the reactions	771:815	The thermodynamic assessment of the reactions validated the retention of both U (VI) and Sr (II) ions by spontaneous, favorable, and exothermic reactions.
33493560	6	45	theme	uptake	1145:1150	arg1	related					1166:1172	related	1166:1172	related	1166:1172	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	6	45	theme	uptake	1145:1150	arg1	processes					1152:1160	the uptake processes	1141:1160	the uptake processes	1141:1160	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	2	46	theme	ions	403:406	arg1	retention					364:372	systematic retention	353:372	systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants	353:465	The prepared CH/MCM-48 composite was applied in systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants.
33493560	5	47	theme	exothermic	904:913	arg1	reactions					915:923	spontaneous, favorable, and exothermic reactions	876:923	spontaneous, favorable, and exothermic reactions	876:923	The thermodynamic assessment of the reactions validated the retention of both U (VI) and Sr (II) ions by spontaneous, favorable, and exothermic reactions.
33493560	2	48	from	retention	364:372	arg1	water					413:417	water	413:417	water	413:417	The prepared CH/MCM-48 composite was applied in systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants.
33493560	5	49	theme	thermodynamic	775:787	arg1	assessment					789:798	The thermodynamic assessment	771:798	The thermodynamic assessment of the reactions	771:815	The thermodynamic assessment of the reactions validated the retention of both U (VI) and Sr (II) ions by spontaneous, favorable, and exothermic reactions.
33493560	6	50	dep	energy	1081:1086	arg1	4.56 kJ mol-1					1116:1128	4.56 kJ mol-1	1116:1128	4.56 kJ mol-1 (Sr (II))	1116:1138	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	6	50	dep	energy	1081:1086	arg1	Sr					1131:1132	Sr (II)	1131:1137	Sr (II)	1131:1137	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	6	50	dep	energy	1081:1086	arg1	5.77 kJ mol-1					1089:1101	5.77 kJ mol-1	1089:1101	5.77 kJ mol-1 (U (VI))	1089:1110	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	1	51	theme	enhanced	275:282	arg1	capacity					295:302	enhanced adsorption capacity	275:302	enhanced adsorption capacity	275:302	The chitosan chains were integrated with MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity.
33493560	7	52	theme	studied	1307:1313	arg1	ions					1327:1330	the studied radioactive ions	1303:1330	the studied radioactive ions	1303:1330	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	3	53	theme	328.6 mg/g	530:539	arg1	capacities					501:510	promising retention capacities	481:510	promising retention capacities of 261.3 mg/g and 328.6 mg/g for U (VI) and Sr (II)	481:562	It displayed promising retention capacities of 261.3 mg/g and 328.6 mg/g for U (VI) and Sr (II) considering the equilibrium time interval that was identified after 420 min.
33493560	2	54	theme	CH/MCM-48	318:326	arg1	composite					328:336	The prepared CH/MCM-48 composite	305:336	The prepared CH/MCM-48 composite	305:336	The prepared CH/MCM-48 composite was applied in systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants.
33493560	7	55	theme	significant	1238:1248	arg1	recyclability					1250:1262	significant recyclability	1238:1262	significant recyclability	1238:1262	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	1	56	theme	adsorption	284:293	arg1	capacity					295:302	enhanced adsorption capacity	275:302	enhanced adsorption capacity	275:302	The chitosan chains were integrated with MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity.
33493560	3	57	theme	time	592:595	arg1	interval					597:604	the equilibrium time interval	576:604	the equilibrium time interval that was identified after 420 min	576:638	It displayed promising retention capacities of 261.3 mg/g and 328.6 mg/g for U (VI) and Sr (II) considering the equilibrium time interval that was identified after 420 min.
33493560	6	58	dep	U	986:986	arg1	VI					989:990	VI	989:990	VI	989:990	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	2	59	theme	prepared	309:316	arg1	composite					328:336	The prepared CH/MCM-48 composite	305:336	The prepared CH/MCM-48 composite	305:336	The prepared CH/MCM-48 composite was applied in systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants.
33493560	1	60	theme	capacity	295:302	arg1	CH/MCM-48					261:269	CH/MCM-48	261:269	CH/MCM-48	261:269	The chitosan chains were integrated with MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity.
33493560	1	60	theme	capacity	295:302	arg1	composite					250:258	an eco-friendly composite	234:258	an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity	234:302	The chitosan chains were integrated with MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity.
33493560	1	60	theme	capacity	295:302	arg1	capacity					295:302	enhanced adsorption capacity	275:302	enhanced adsorption capacity	275:302	The chitosan chains were integrated with MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity.
33493560	6	61	theme	energy	1036:1041	arg1	values					951:956	the theoretical values	935:956	the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II)))	935:1139	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	5	62	theme	spontaneous	876:886	arg1	reactions					915:923	spontaneous, favorable, and exothermic reactions	876:923	spontaneous, favorable, and exothermic reactions	876:923	The thermodynamic assessment of the reactions validated the retention of both U (VI) and Sr (II) ions by spontaneous, favorable, and exothermic reactions.
33493560	6	63	dep	-5.94 kJ mol-1	970:983	arg1	U					986:986	U	986:986	U	986:986	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	6	64	dep	energy	1036:1041	arg1	20 kJ mol-1					1054:1064	20 kJ mol-1	1054:1064	20 kJ mol-1	1054:1064	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	7	65	theme	metal	1362:1366	arg1	Zn					1392:1393	Zn (II)	1392:1398	Zn (II)	1392:1398	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	65	theme	metal	1362:1366	arg1	Pb					1383:1384	Pb (II)	1383:1389	Pb (II)	1383:1389	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	65	theme	metal	1362:1366	arg1	Cd					1374:1375	Cd (II)	1374:1380	Cd (II)	1374:1380	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	65	theme	metal	1362:1366	arg1	Co					1405:1406	Co (II)	1405:1411	Co (II)	1405:1411	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	65	theme	metal	1362:1366	arg1	ions					1368:1371	other metal ions	1356:1371	other metal ions (Cd (II), Pb (II), Zn (II), and Co (II))	1356:1412	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	0	66	theme	aqueous	131:137	arg1	solutions					139:147	aqueous solutions	131:147	aqueous solutions	131:147	Insight into chitosan/mesoporous silica nanocomposites as eco-friendly adsorbent for enhanced retention of U (VI) and Sr (II) from aqueous solutions and real water.
33493560	4	67	theme	model	709:713	arg1	behavior					674:681	the kinetic behavior	662:681	the kinetic behavior of the Pseudo-First order model	662:713	The composite showed the kinetic behavior of the Pseudo-First order model and the isotherm properties of the Langmuir assumption.
33493560	4	67	theme	model	709:713	arg1	properties					732:741	the isotherm properties	719:741	the isotherm properties of the Langmuir assumption	719:768	The composite showed the kinetic behavior of the Pseudo-First order model and the isotherm properties of the Langmuir assumption.
33493560	0	68	theme	enhanced	85:92	arg1	retention					94:102	enhanced retention	85:102	enhanced retention of U (VI) and Sr (II) from aqueous solutions	85:147	Insight into chitosan/mesoporous silica nanocomposites as eco-friendly adsorbent for enhanced retention of U (VI) and Sr (II) from aqueous solutions and real water.
33493560	3	69	theme	equilibrium	580:590	arg1	interval					597:604	the equilibrium time interval	576:604	the equilibrium time interval that was identified after 420 min	576:638	It displayed promising retention capacities of 261.3 mg/g and 328.6 mg/g for U (VI) and Sr (II) considering the equilibrium time interval that was identified after 420 min.
33493560	2	70	dep	U	377:377	arg1	VI					380:381	VI	380:381	VI	380:381	The prepared CH/MCM-48 composite was applied in systematic retention of U (VI) as well as Sr (II) ions from water as the commonly detected radioactive pollutants.
33493560	6	71	theme	theoretical	939:949	arg1	values					951:956	the theoretical values	935:956	the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II)))	935:1139	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	7	72	dep	ions	1368:1371	arg1	Zn					1392:1393	Zn (II)	1392:1398	Zn (II)	1392:1398	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	72	dep	ions	1368:1371	arg1	Co					1405:1406	Co (II)	1405:1411	Co (II)	1405:1411	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	72	dep	ions	1368:1371	arg1	ions					1368:1371	other metal ions	1356:1371	other metal ions (Cd (II), Pb (II), Zn (II), and Co (II))	1356:1412	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	72	dep	ions	1368:1371	arg1	Pb					1383:1384	Pb (II)	1383:1389	Pb (II)	1383:1389	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	72	dep	ions	1368:1371	arg1	the					1340:1342	the	1340:1342	the	1340:1342	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	72	dep	ions	1368:1371	arg1	presence					1344:1351	presence	1344:1351	presence	1344:1351	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	7	72	dep	ions	1368:1371	arg1	Cd					1374:1375	Cd (II)	1374:1380	Cd (II)	1374:1380	The CH/MCM-48 composite is of significant recyclability and showed considerable affinities for the studied radioactive ions even in the presence of other metal ions (Cd (II), Pb (II), Zn (II), and Co (II)).
33493560	6	73	theme	physical	1177:1184	arg1	reactions					1197:1205	physical adsorption reactions	1177:1205	physical adsorption reactions	1177:1205	Based on the theoretical values of entropy (-5.94 kJ mol-1 (U (VI)) and -2.93 kJ mol-1 (Sr (II))), Gibbs free energy (less than 20 kJ mol-1), and Gaussian energy (5.77 kJ mol-1 (U (VI)) and 4.56 kJ mol-1 (Sr (II))) the uptake processes are related to physical adsorption reactions.
33493560	1	74	theme	mesoporous	213:222	arg1	silica					224:229	MCM-48 mesoporous silica	206:229	MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity	206:302	The chitosan chains were integrated with MCM-48 mesoporous silica in an eco-friendly composite (CH/MCM-48) of enhanced adsorption capacity.
33712164	6	0	theme	pressure-responsive	886:904	arg1	color					906:910	the pressure-responsive color	882:910	the pressure-responsive color	882:910	Furthermore, the pressure-responsive color is still vivid after 16 cycles of compression.
33712164	1	1	theme	nanocrystals	180:191	arg1	glycol					214:219	ethylene glycol	205:219	ethylene glycol	205:219	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	1	1	theme	nanocrystals	180:191	arg1	PEG					223:225	PEG	223:225	PEG	223:225	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	1	1	theme	nanocrystals	180:191	arg1	skeleton					158:165	aerogel skeleton	150:165	aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method	150:265	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	1	2	theme	ice-templating	245:258	arg1	method					260:265	the ice-templating method	241:265	the ice-templating method	241:265	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	1	3	theme	pressure-responsive	65:83	arg1	sensor					85:90	A bio-based pressure-responsive sensor	53:90	A bio-based pressure-responsive sensor with adjustable structural color	53:123	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	4	4	theme	Helical	578:584	arg1	pitches					586:592	Helical pitches	578:592	Helical pitches	578:592	Helical pitches are regulated by the PEG content that the wavelength of structural color covers up to 178 nm.
33712164	5	5	theme	excellent	700:708	arg1	correlation					717:727	an excellent linear correlation	697:727	an excellent linear correlation between pressure and transmittance of reflectance peak	697:782	There is an excellent linear correlation between pressure and transmittance of reflectance peak, and the sensitivity to pressure can be regulated by changing solid content of PAAM.
33712164	3	6	theme	3D	541:542	arg1	aerogel					544:550	the 3D aerogel	537:550	the 3D aerogel	537:550	These ribbons are rearranged to be vertical to the force direction, leading to immediate appearance of the structural color when the 3D aerogel transforms to a 2D plane.
33712164	2	7	theme	consecutive	347:357	arg1	ribbons					359:365	consecutive ribbons	347:365	consecutive ribbons	347:365	The white aerogel is composed of consecutive ribbons, demonstrating chiral nematic structure.
33712164	7	8	with	material	973:980	arg1	color					1018:1022	pressure-responsive structural color	987:1022	pressure-responsive structural color	987:1022	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
33712164	5	9	theme	linear	710:715	arg1	correlation					717:727	an excellent linear correlation	697:727	an excellent linear correlation between pressure and transmittance of reflectance peak	697:782	There is an excellent linear correlation between pressure and transmittance of reflectance peak, and the sensitivity to pressure can be regulated by changing solid content of PAAM.
33712164	3	10	theme	color	526:530	arg1	appearance					497:506	immediate appearance	487:506	immediate appearance of the structural color	487:530	These ribbons are rearranged to be vertical to the force direction, leading to immediate appearance of the structural color when the 3D aerogel transforms to a 2D plane.
33712164	4	11	theme	structural	650:659	arg1	color					661:665	structural color	650:665	structural color	650:665	Helical pitches are regulated by the PEG content that the wavelength of structural color covers up to 178 nm.
33712164	4	12	theme	PEG	615:617	arg1	content					619:625	the PEG content	611:625	the PEG content that the wavelength of structural color covers up to 178 nm	611:685	Helical pitches are regulated by the PEG content that the wavelength of structural color covers up to 178 nm.
33712164	1	13	theme	adjustable	97:106	arg1	color					119:123	adjustable structural color	97:123	adjustable structural color	97:123	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	2	14	theme	nematic	389:395	arg1	structure					397:405	chiral nematic structure	382:405	chiral nematic structure	382:405	The white aerogel is composed of consecutive ribbons, demonstrating chiral nematic structure.
33712164	0	15	theme	visual	10:15	arg1	sensor					45:50	Bio-based visual optical pressure-responsive sensor	0:50	Bio-based visual optical pressure-responsive sensor	0:50	Bio-based visual optical pressure-responsive sensor.
33712164	3	16	theme	structural	515:524	arg1	color					526:530	the structural color	511:530	the structural color	511:530	These ribbons are rearranged to be vertical to the force direction, leading to immediate appearance of the structural color when the 3D aerogel transforms to a 2D plane.
33712164	7	17	theme	information	1070:1080	arg1	transmission					1082:1093	information transmission	1070:1093	information transmission	1070:1093	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
33712164	6	18	theme	compression	946:956	arg1	cycles					936:941	16 cycles	933:941	16 cycles of compression	933:956	Furthermore, the pressure-responsive color is still vivid after 16 cycles of compression.
33712164	1	19	theme	structural	108:117	arg1	color					119:123	adjustable structural color	97:123	adjustable structural color	97:123	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	2	20	theme	chiral	382:387	arg1	structure					397:405	chiral nematic structure	382:405	chiral nematic structure	382:405	The white aerogel is composed of consecutive ribbons, demonstrating chiral nematic structure.
33712164	0	21	theme	Bio-based	0:8	arg1	sensor					45:50	Bio-based visual optical pressure-responsive sensor	0:50	Bio-based visual optical pressure-responsive sensor	0:50	Bio-based visual optical pressure-responsive sensor.
33712164	1	22	theme	flexible	272:279	arg1	elastomer					303:311	flexible polyacrylamide (PAAM) elastomer	272:311	flexible polyacrylamide (PAAM) elastomer	272:311	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	0	23	theme	pressure-responsive	25:43	arg1	sensor					45:50	Bio-based visual optical pressure-responsive sensor	0:50	Bio-based visual optical pressure-responsive sensor	0:50	Bio-based visual optical pressure-responsive sensor.
33712164	1	24	theme	polyacrylamide	281:294	arg1	elastomer					303:311	flexible polyacrylamide (PAAM) elastomer	272:311	flexible polyacrylamide (PAAM) elastomer	272:311	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	1	25	theme	ethylene	205:212	arg1	glycol					214:219	ethylene glycol	205:219	ethylene glycol	205:219	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	1	25	theme	ethylene	205:212	arg1	skeleton					158:165	aerogel skeleton	150:165	aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method	150:265	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	0	26	theme	optical	17:23	arg1	sensor					45:50	Bio-based visual optical pressure-responsive sensor	0:50	Bio-based visual optical pressure-responsive sensor	0:50	Bio-based visual optical pressure-responsive sensor.
33712164	1	27	theme	PAAM	297:300	arg1	elastomer					303:311	flexible polyacrylamide (PAAM) elastomer	272:311	flexible polyacrylamide (PAAM) elastomer	272:311	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	5	28	theme	reflectance	767:777	arg1	peak					779:782	reflectance peak	767:782	reflectance peak	767:782	There is an excellent linear correlation between pressure and transmittance of reflectance peak, and the sensitivity to pressure can be regulated by changing solid content of PAAM.
33712164	7	29	from	etc	1100:1102	arg1	promising					1027:1035	promising	1027:1035	promising	1027:1035	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
33712164	5	30	theme	solid	846:850	arg1	content					852:858	solid content	846:858	solid content of PAAM	846:866	There is an excellent linear correlation between pressure and transmittance of reflectance peak, and the sensitivity to pressure can be regulated by changing solid content of PAAM.
33712164	4	31	dep	content	619:625	arg1	covers					667:672	covers	667:672	covers up to 178 nm	667:685	Helical pitches are regulated by the PEG content that the wavelength of structural color covers up to 178 nm.
33712164	7	32	theme	structural	1007:1016	arg1	color					1018:1022	pressure-responsive structural color	987:1022	pressure-responsive structural color	987:1022	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
33712164	5	33	theme	peak	779:782	arg1	pressure					737:744	pressure	737:744	pressure	737:744	There is an excellent linear correlation between pressure and transmittance of reflectance peak, and the sensitivity to pressure can be regulated by changing solid content of PAAM.
33712164	5	33	theme	peak	779:782	arg1	transmittance					750:762	transmittance	750:762	transmittance	750:762	There is an excellent linear correlation between pressure and transmittance of reflectance peak, and the sensitivity to pressure can be regulated by changing solid content of PAAM.
33712164	7	34	from	transmission	1082:1093	arg1	promising					1027:1035	promising	1027:1035	promising	1027:1035	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
33712164	3	35	theme	2D	568:569	arg1	plane					571:575	a 2D plane	566:575	a 2D plane	566:575	These ribbons are rearranged to be vertical to the force direction, leading to immediate appearance of the structural color when the 3D aerogel transforms to a 2D plane.
33712164	7	36	theme	intelligent	1049:1059	arg1	display					1061:1067	intelligent display	1049:1067	intelligent display	1049:1067	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
33712164	1	37	with	sensor	85:90	arg1	color					119:123	adjustable structural color	97:123	adjustable structural color	97:123	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	3	38	theme	immediate	487:495	arg1	appearance					497:506	immediate appearance	487:506	immediate appearance of the structural color	487:530	These ribbons are rearranged to be vertical to the force direction, leading to immediate appearance of the structural color when the 3D aerogel transforms to a 2D plane.
33712164	4	39	theme	color	661:665	arg1	wavelength					636:645	the wavelength	632:645	the wavelength of structural color	632:665	Helical pitches are regulated by the PEG content that the wavelength of structural color covers up to 178 nm.
33712164	1	40	theme	aerogel	150:156	arg1	glycol					214:219	ethylene glycol	205:219	ethylene glycol	205:219	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	1	40	theme	aerogel	150:156	arg1	PEG					223:225	PEG	223:225	PEG	223:225	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	1	40	theme	aerogel	150:156	arg1	skeleton					158:165	aerogel skeleton	150:165	aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method	150:265	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	7	41	theme	pressure-responsive	987:1005	arg1	color					1018:1022	pressure-responsive structural color	987:1022	pressure-responsive structural color	987:1022	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
33712164	7	42	theme	flexible	964:971	arg1	material					973:980	This flexible material	959:980	This flexible material with pressure-responsive structural color	959:1022	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
33712164	2	43	theme	white	318:322	arg1	aerogel					324:330	The white aerogel	314:330	The white aerogel	314:330	The white aerogel is composed of consecutive ribbons, demonstrating chiral nematic structure.
33712164	7	44	from	promising	1027:1035	arg1	sensing					1040:1046	sensing	1040:1046	sensing	1040:1046	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
33712164	7	44	from	promising	1027:1035	arg1	display					1061:1067	intelligent display	1049:1067	intelligent display	1049:1067	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
33712164	7	44	from	promising	1027:1035	arg1	transmission					1082:1093	information transmission	1070:1093	information transmission	1070:1093	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
33712164	7	44	from	promising	1027:1035	arg1	etc					1100:1102	etc	1100:1102	etc	1100:1102	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
33712164	3	45	theme	force	459:463	arg1	direction					465:473	the force direction	455:473	the force direction	455:473	These ribbons are rearranged to be vertical to the force direction, leading to immediate appearance of the structural color when the 3D aerogel transforms to a 2D plane.
33712164	5	46	theme	PAAM	863:866	arg1	content					852:858	solid content	846:858	solid content of PAAM	846:866	There is an excellent linear correlation between pressure and transmittance of reflectance peak, and the sensitivity to pressure can be regulated by changing solid content of PAAM.
33712164	7	47	from	display	1061:1067	arg1	promising					1027:1035	promising	1027:1035	promising	1027:1035	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
33712164	1	48	theme	bio-based	55:63	arg1	sensor					85:90	A bio-based pressure-responsive sensor	53:90	A bio-based pressure-responsive sensor with adjustable structural color	53:123	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	1	49	theme	cellulose	170:178	arg1	CNCs					194:197	CNCs	194:197	CNCs	194:197	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	1	49	theme	cellulose	170:178	arg1	nanocrystals					180:191	cellulose nanocrystals	170:191	cellulose nanocrystals (CNCs)	170:198	A bio-based pressure-responsive sensor with adjustable structural color is prepared by combining aerogel skeleton of cellulose nanocrystals (CNCs)/poly(ethylene glycol) (PEG) obtained via the ice-templating method with flexible polyacrylamide (PAAM) elastomer.
33712164	7	50	from	sensing	1040:1046	arg1	promising					1027:1035	promising	1027:1035	promising	1027:1035	This flexible material with pressure-responsive structural color is promising in sensing, intelligent display, information transmission, and etc.
34761701	7	0	theme	different	1171:1179	arg1	volumes					1181:1187	the different volumes	1167:1187	the different volumes	1167:1187	On the other hand, IL-6 secretion induced by lipopolysaccharide (LPS) did not differ among mAM obtained from BALF collected using the different volumes.
34761701	11	1	from	mice	1769:1772	arg1	BALF					1759:1762	BALF	1759:1762	BALF from mice	1759:1772	These observations illustrate that larger volumes of buffer used to collect BALF from mice can affect sensitivity of the isolated mAM to ex vivo particle-induced responses by inhibiting their functions.
34761701	11	2	theme	larger	1718:1723	arg1	volumes					1725:1731	larger volumes	1718:1731	larger volumes of buffer used to collect BALF from mice	1718:1772	These observations illustrate that larger volumes of buffer used to collect BALF from mice can affect sensitivity of the isolated mAM to ex vivo particle-induced responses by inhibiting their functions.
34761701	4	3	theme	particle-induced	693:708	arg1	responses					710:718	ex vivo particle-induced responses	685:718	ex vivo particle-induced responses	685:718	In this study, effects of injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses were assessed.
34761701	6	4	theme	buffer	984:989	arg1	composition					991:1001	Injected buffer composition	975:1001	Injected buffer composition	975:1001	Injected buffer composition did not affect the IL-1α release.
34761701	7	5	theme	IL-6	1056:1059	arg1	secretion					1061:1069	IL-6 secretion	1056:1069	IL-6 secretion induced by lipopolysaccharide (LPS)	1056:1105	On the other hand, IL-6 secretion induced by lipopolysaccharide (LPS) did not differ among mAM obtained from BALF collected using the different volumes.
34761701	10	6	theme	0.75 ml	1667:1673	arg1	buffer					1675:1680	0.75 ml buffer	1667:1680	0.75 ml buffer	1667:1680	Decreases in RIPK3 phosphorylation were noted in mAM obtained in BALF collected using the 1.0 ml injection volume compared with mAM obtained in BALF using 0.55 or 0.75 ml buffer.
34761701	4	7	theme	volume	589:594	arg1	effects					561:567	effects	561:567	effects of injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses	561:718	In this study, effects of injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses were assessed.
34761701	0	8	theme	alveolar	99:106	arg1	macrophages					108:118	alveolar macrophages	99:118	alveolar macrophages	99:118	Impact of injection buffer volume to perform bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion.
34761701	5	9	theme	silica	942:947	arg1	crystal					949:955	silica crystal or aluminum salt	942:972	crystal	949:955	Among the mAM obtained from BALF collected using a 0.55 or 0.75 ml, but not a 1.0 ml buffer injection volume, decreased cell viability and IL-1α release were observed when cells were stimulated ex vivo with silica crystal or aluminum salt.
34761701	11	10	dep	ex	1820:1821	arg1	vivo					1823:1826	vivo	1823:1826	vivo	1823:1826	These observations illustrate that larger volumes of buffer used to collect BALF from mice can affect sensitivity of the isolated mAM to ex vivo particle-induced responses by inhibiting their functions.
34761701	10	11	theme	injection	1601:1609	arg1	volume					1611:1616	the 1.0 ml injection volume	1590:1616	the 1.0 ml injection volume	1590:1616	Decreases in RIPK3 phosphorylation were noted in mAM obtained in BALF collected using the 1.0 ml injection volume compared with mAM obtained in BALF using 0.55 or 0.75 ml buffer.
34761701	9	12	theme	cytochalasin	1475:1486	arg1	D					1488:1488	cytochalasin D	1475:1488	cytochalasin D	1475:1488	IL-1α release (and also necroptosis) induced by ex vivoparticle stimulation was suppressed by RIPK3 inhibitor or cytochalasin D co-treatment.
34761701	4	13	from	use	678:680	arg1	responses					710:718	ex vivo particle-induced responses	685:718	ex vivo particle-induced responses	685:718	In this study, effects of injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses were assessed.
34761701	9	14	theme	RIPK3	1456:1460	arg1	inhibitor					1462:1470	RIPK3 inhibitor	1456:1470	RIPK3 inhibitor	1456:1470	IL-1α release (and also necroptosis) induced by ex vivoparticle stimulation was suppressed by RIPK3 inhibitor or cytochalasin D co-treatment.
34761701	11	15	theme	isolated	1804:1811	arg1	mAM					1813:1815	the isolated mAM	1800:1815	the isolated mAM	1800:1815	These observations illustrate that larger volumes of buffer used to collect BALF from mice can affect sensitivity of the isolated mAM to ex vivo particle-induced responses by inhibiting their functions.
34761701	5	16	theme	decreased	845:853	arg1	viability					860:868	decreased cell viability	845:868	decreased cell viability	845:868	Among the mAM obtained from BALF collected using a 0.55 or 0.75 ml, but not a 1.0 ml buffer injection volume, decreased cell viability and IL-1α release were observed when cells were stimulated ex vivo with silica crystal or aluminum salt.
34761701	4	17	dep	ex	685:686	arg1	vivo					688:691	vivo	688:691	vivo	688:691	In this study, effects of injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses were assessed.
34761701	1	18	theme	macrophages	201:211	arg1	importance					178:187	The importance	174:187	The importance of alveolar macrophages	174:211	The importance of alveolar macrophages has been reported in many toxicology/immunology studies.
34761701	10	19	theme	RIPK3	1517:1521	arg1	phosphorylation					1523:1537	RIPK3 phosphorylation	1517:1537	RIPK3 phosphorylation	1517:1537	Decreases in RIPK3 phosphorylation were noted in mAM obtained in BALF collected using the 1.0 ml injection volume compared with mAM obtained in BALF using 0.55 or 0.75 ml buffer.
34761701	9	20	theme	IL-1α	1362:1366	arg1	release					1368:1374	IL-1α release	1362:1374	IL-1α release (and also necroptosis) induced by ex vivoparticle stimulation	1362:1436	IL-1α release (and also necroptosis) induced by ex vivoparticle stimulation was suppressed by RIPK3 inhibitor or cytochalasin D co-treatment.
34761701	9	20	theme	IL-1α	1362:1366	arg1	necroptosis					1386:1396	necroptosis	1386:1396	necroptosis	1386:1396	IL-1α release (and also necroptosis) induced by ex vivoparticle stimulation was suppressed by RIPK3 inhibitor or cytochalasin D co-treatment.
34761701	5	21	theme	aluminum	960:967	arg1	salt					969:972	silica crystal or aluminum salt	942:972	salt	969:972	Among the mAM obtained from BALF collected using a 0.55 or 0.75 ml, but not a 1.0 ml buffer injection volume, decreased cell viability and IL-1α release were observed when cells were stimulated ex vivo with silica crystal or aluminum salt.
34761701	1	22	theme	alveolar	192:199	arg1	macrophages					201:211	alveolar macrophages	192:211	alveolar macrophages	192:211	The importance of alveolar macrophages has been reported in many toxicology/immunology studies.
34761701	5	23	theme	IL-1α	874:878	arg1	release					880:886	IL-1α release	874:886	IL-1α release	874:886	Among the mAM obtained from BALF collected using a 0.55 or 0.75 ml, but not a 1.0 ml buffer injection volume, decreased cell viability and IL-1α release were observed when cells were stimulated ex vivo with silica crystal or aluminum salt.
34761701	3	24	theme	isolation	438:446	arg1	procedures					448:457	cell isolation procedures	433:457	cell isolation procedures	433:457	However, it is unclear whether cell isolation procedures affect ex vivo particle-induced responses in primary mouse alveolar macrophages (mAM).
34761701	5	25	dep	0.55	786:789	arg1	a					784:784	a	784:784	a	784:784	Among the mAM obtained from BALF collected using a 0.55 or 0.75 ml, but not a 1.0 ml buffer injection volume, decreased cell viability and IL-1α release were observed when cells were stimulated ex vivo with silica crystal or aluminum salt.
34761701	2	26	theme	molecular	342:350	arg1	-1α					315:317	interleukin (IL)-1α	299:317	interleukin (IL)-1α	299:317	Alveolar macrophages release interleukin (IL)-1α as a damage-associated molecular pattern (DAMP) when stimulated by fine particles.
34761701	2	26	theme	molecular	342:350	arg1	DAMP					361:364	DAMP	361:364	DAMP	361:364	Alveolar macrophages release interleukin (IL)-1α as a damage-associated molecular pattern (DAMP) when stimulated by fine particles.
34761701	2	26	theme	molecular	342:350	arg1	pattern					352:358	a damage-associated molecular pattern	322:358	a damage-associated molecular pattern (DAMP)	322:365	Alveolar macrophages release interleukin (IL)-1α as a damage-associated molecular pattern (DAMP) when stimulated by fine particles.
34761701	8	27	theme	markers	1224:1230	arg1	levels					1201:1206	Expression levels	1190:1206	Expression levels of cell surface markers like CD11c, SiglecF, and CD64	1190:1260	Expression levels of cell surface markers like CD11c, SiglecF, and CD64 did not differ among mAM obtained from BALF collected using the different injection buffer volumes.
34761701	8	28	theme	cell	1211:1214	arg1	markers					1224:1230	cell surface markers	1211:1230	cell surface markers like CD11c, SiglecF, and CD64	1211:1260	Expression levels of cell surface markers like CD11c, SiglecF, and CD64 did not differ among mAM obtained from BALF collected using the different injection buffer volumes.
34761701	0	29	theme	buffer	20:25	arg1	volume					27:32	injection buffer volume	10:32	injection buffer volume	10:32	Impact of injection buffer volume to perform bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion.
34761701	11	30	theme	buffer	1736:1741	arg1	volumes					1725:1731	larger volumes	1718:1731	larger volumes of buffer used to collect BALF from mice	1718:1772	These observations illustrate that larger volumes of buffer used to collect BALF from mice can affect sensitivity of the isolated mAM to ex vivo particle-induced responses by inhibiting their functions.
34761701	0	31	theme	fine	135:138	arg1	secretion					163:171	fine particle-induced IL-1α secretion	135:171	fine particle-induced IL-1α secretion	135:171	Impact of injection buffer volume to perform bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion.
34761701	9	32	dep	necroptosis	1386:1396	arg1	also					1381:1384	also	1381:1384	also	1381:1384	IL-1α release (and also necroptosis) induced by ex vivoparticle stimulation was suppressed by RIPK3 inhibitor or cytochalasin D co-treatment.
34761701	2	33	theme	damage-associated	324:340	arg1	-1α					315:317	interleukin (IL)-1α	299:317	interleukin (IL)-1α	299:317	Alveolar macrophages release interleukin (IL)-1α as a damage-associated molecular pattern (DAMP) when stimulated by fine particles.
34761701	2	33	theme	damage-associated	324:340	arg1	DAMP					361:364	DAMP	361:364	DAMP	361:364	Alveolar macrophages release interleukin (IL)-1α as a damage-associated molecular pattern (DAMP) when stimulated by fine particles.
34761701	2	33	theme	damage-associated	324:340	arg1	pattern					352:358	a damage-associated molecular pattern	322:358	a damage-associated molecular pattern (DAMP)	322:365	Alveolar macrophages release interleukin (IL)-1α as a damage-associated molecular pattern (DAMP) when stimulated by fine particles.
34761701	8	34	theme	buffer	1346:1351	arg1	volumes					1353:1359	the different injection buffer volumes	1322:1359	the different injection buffer volumes	1322:1359	Expression levels of cell surface markers like CD11c, SiglecF, and CD64 did not differ among mAM obtained from BALF collected using the different injection buffer volumes.
34761701	5	35	theme	1.0 ml	813:818	arg1	volume					837:842	a 1.0 ml buffer injection volume	811:842	a 1.0 ml buffer injection volume	811:842	Among the mAM obtained from BALF collected using a 0.55 or 0.75 ml, but not a 1.0 ml buffer injection volume, decreased cell viability and IL-1α release were observed when cells were stimulated ex vivo with silica crystal or aluminum salt.
34761701	0	36	theme	injection	10:18	arg1	volume					27:32	injection buffer volume	10:32	injection buffer volume	10:32	Impact of injection buffer volume to perform bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion.
34761701	4	37	theme	buffer	582:587	arg1	volume					589:594	injection buffer volume	572:594	injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses	572:718	In this study, effects of injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses were assessed.
34761701	4	38	theme	lavage	628:633	arg1	BALF					642:645	BALF	642:645	BALF	642:645	In this study, effects of injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses were assessed.
34761701	4	38	theme	lavage	628:633	arg1	fluid					635:639	bronchoalveolar lavage fluid	612:639	bronchoalveolar lavage fluid (BALF) collection	612:657	In this study, effects of injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses were assessed.
34761701	11	39	theme	ex	1820:1821	arg1	responses					1845:1853	ex vivo particle-induced responses	1820:1853	ex vivo particle-induced responses	1820:1853	These observations illustrate that larger volumes of buffer used to collect BALF from mice can affect sensitivity of the isolated mAM to ex vivo particle-induced responses by inhibiting their functions.
34761701	5	40	theme	buffer	820:825	arg1	volume					837:842	a 1.0 ml buffer injection volume	811:842	a 1.0 ml buffer injection volume	811:842	Among the mAM obtained from BALF collected using a 0.55 or 0.75 ml, but not a 1.0 ml buffer injection volume, decreased cell viability and IL-1α release were observed when cells were stimulated ex vivo with silica crystal or aluminum salt.
34761701	4	41	theme	injection	572:580	arg1	volume					589:594	injection buffer volume	572:594	injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses	572:718	In this study, effects of injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses were assessed.
34761701	0	42	theme	IL-1α	157:161	arg1	secretion					163:171	fine particle-induced IL-1α secretion	135:171	fine particle-induced IL-1α secretion	135:171	Impact of injection buffer volume to perform bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion.
34761701	6	43	theme	IL-1α	1022:1026	arg1	release					1028:1034	the IL-1α release	1018:1034	the IL-1α release	1018:1034	Injected buffer composition did not affect the IL-1α release.
34761701	2	44	theme	Alveolar	270:277	arg1	macrophages					279:289	Alveolar macrophages	270:289	Alveolar macrophages	270:289	Alveolar macrophages release interleukin (IL)-1α as a damage-associated molecular pattern (DAMP) when stimulated by fine particles.
34761701	10	45	theme	1.0 ml	1594:1599	arg1	volume					1611:1616	the 1.0 ml injection volume	1590:1616	the 1.0 ml injection volume	1590:1616	Decreases in RIPK3 phosphorylation were noted in mAM obtained in BALF collected using the 1.0 ml injection volume compared with mAM obtained in BALF using 0.55 or 0.75 ml buffer.
34761701	5	46	theme	injection	827:835	arg1	volume					837:842	a 1.0 ml buffer injection volume	811:842	a 1.0 ml buffer injection volume	811:842	Among the mAM obtained from BALF collected using a 0.55 or 0.75 ml, but not a 1.0 ml buffer injection volume, decreased cell viability and IL-1α release were observed when cells were stimulated ex vivo with silica crystal or aluminum salt.
34761701	0	47	theme	volume	27:32	arg1	Impact					0:5	Impact	0:5	Impact of injection buffer volume	0:32	Impact of injection buffer volume to perform bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion.
34761701	0	48	theme	particle-induced	140:155	arg1	secretion					163:171	fine particle-induced IL-1α secretion	135:171	fine particle-induced IL-1α secretion	135:171	Impact of injection buffer volume to perform bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion.
34761701	6	49	theme	Injected	975:982	arg1	composition					991:1001	Injected buffer composition	975:1001	Injected buffer composition	975:1001	Injected buffer composition did not affect the IL-1α release.
34761701	8	50	theme	injection	1336:1344	arg1	volumes					1353:1359	the different injection buffer volumes	1322:1359	the different injection buffer volumes	1322:1359	Expression levels of cell surface markers like CD11c, SiglecF, and CD64 did not differ among mAM obtained from BALF collected using the different injection buffer volumes.
34761701	1	51	theme	many	234:237	arg1	studies					261:267	many toxicology/immunology studies	234:267	many toxicology/immunology studies	234:267	The importance of alveolar macrophages has been reported in many toxicology/immunology studies.
34761701	0	52	theme	bronchoalveolar	45:59	arg1	fluid					68:72	bronchoalveolar lavage fluid	45:72	bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion	45:171	Impact of injection buffer volume to perform bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion.
34761701	5	53	theme	cell	855:858	arg1	viability					860:868	decreased cell viability	845:868	decreased cell viability	845:868	Among the mAM obtained from BALF collected using a 0.55 or 0.75 ml, but not a 1.0 ml buffer injection volume, decreased cell viability and IL-1α release were observed when cells were stimulated ex vivo with silica crystal or aluminum salt.
34761701	10	54	from	Decreases	1504:1512	arg1	phosphorylation					1523:1537	RIPK3 phosphorylation	1517:1537	RIPK3 phosphorylation	1517:1537	Decreases in RIPK3 phosphorylation were noted in mAM obtained in BALF collected using the 1.0 ml injection volume compared with mAM obtained in BALF using 0.55 or 0.75 ml buffer.
34761701	3	55	theme	alveolar	518:525	arg1	mAM					540:542	mAM	540:542	mAM	540:542	However, it is unclear whether cell isolation procedures affect ex vivo particle-induced responses in primary mouse alveolar macrophages (mAM).
34761701	3	55	theme	alveolar	518:525	arg1	macrophages					527:537	primary mouse alveolar macrophages	504:537	primary mouse alveolar macrophages (mAM)	504:543	However, it is unclear whether cell isolation procedures affect ex vivo particle-induced responses in primary mouse alveolar macrophages (mAM).
34761701	11	56	theme	particle-induced	1828:1843	arg1	responses					1845:1853	ex vivo particle-induced responses	1820:1853	ex vivo particle-induced responses	1820:1853	These observations illustrate that larger volumes of buffer used to collect BALF from mice can affect sensitivity of the isolated mAM to ex vivo particle-induced responses by inhibiting their functions.
34761701	7	57	theme	other	1044:1048	arg1	hand					1050:1053	the other hand	1040:1053	the other hand	1040:1053	On the other hand, IL-6 secretion induced by lipopolysaccharide (LPS) did not differ among mAM obtained from BALF collected using the different volumes.
34761701	3	58	dep	ex	466:467	arg1	vivo					469:472	vivo	469:472	vivo	469:472	However, it is unclear whether cell isolation procedures affect ex vivo particle-induced responses in primary mouse alveolar macrophages (mAM).
34761701	9	59	theme	ex	1410:1411	arg1	stimulation					1426:1436	ex vivoparticle stimulation	1410:1436	ex vivoparticle stimulation	1410:1436	IL-1α release (and also necroptosis) induced by ex vivoparticle stimulation was suppressed by RIPK3 inhibitor or cytochalasin D co-treatment.
34761701	11	60	theme	mAM	1813:1815	arg1	sensitivity					1785:1795	sensitivity	1785:1795	sensitivity of the isolated mAM to ex vivo particle-induced responses	1785:1853	These observations illustrate that larger volumes of buffer used to collect BALF from mice can affect sensitivity of the isolated mAM to ex vivo particle-induced responses by inhibiting their functions.
34761701	9	61	dep	inhibitor	1462:1470	arg1	co-treatment					1490:1501	co-treatment	1490:1501	co-treatment	1490:1501	IL-1α release (and also necroptosis) induced by ex vivoparticle stimulation was suppressed by RIPK3 inhibitor or cytochalasin D co-treatment.
34761701	8	62	theme	surface	1216:1222	arg1	markers					1224:1230	cell surface markers	1211:1230	cell surface markers like CD11c, SiglecF, and CD64	1211:1260	Expression levels of cell surface markers like CD11c, SiglecF, and CD64 did not differ among mAM obtained from BALF collected using the different injection buffer volumes.
34761701	3	63	theme	primary	504:510	arg1	mAM					540:542	mAM	540:542	mAM	540:542	However, it is unclear whether cell isolation procedures affect ex vivo particle-induced responses in primary mouse alveolar macrophages (mAM).
34761701	3	63	theme	primary	504:510	arg1	macrophages					527:537	primary mouse alveolar macrophages	504:537	primary mouse alveolar macrophages (mAM)	504:543	However, it is unclear whether cell isolation procedures affect ex vivo particle-induced responses in primary mouse alveolar macrophages (mAM).
34761701	8	64	theme	different	1326:1334	arg1	volumes					1353:1359	the different injection buffer volumes	1322:1359	the different injection buffer volumes	1322:1359	Expression levels of cell surface markers like CD11c, SiglecF, and CD64 did not differ among mAM obtained from BALF collected using the different injection buffer volumes.
34761701	1	65	theme	toxicology/immunology	239:259	arg1	studies					261:267	many toxicology/immunology studies	234:267	many toxicology/immunology studies	234:267	The importance of alveolar macrophages has been reported in many toxicology/immunology studies.
34761701	2	66	theme	interleukin	299:309	arg1	-1α					315:317	interleukin (IL)-1α	299:317	interleukin (IL)-1α	299:317	Alveolar macrophages release interleukin (IL)-1α as a damage-associated molecular pattern (DAMP) when stimulated by fine particles.
34761701	2	66	theme	interleukin	299:309	arg1	pattern					352:358	a damage-associated molecular pattern	322:358	a damage-associated molecular pattern (DAMP)	322:365	Alveolar macrophages release interleukin (IL)-1α as a damage-associated molecular pattern (DAMP) when stimulated by fine particles.
34761701	3	67	theme	mouse	512:516	arg1	mAM					540:542	mAM	540:542	mAM	540:542	However, it is unclear whether cell isolation procedures affect ex vivo particle-induced responses in primary mouse alveolar macrophages (mAM).
34761701	3	67	theme	mouse	512:516	arg1	macrophages					527:537	primary mouse alveolar macrophages	504:537	primary mouse alveolar macrophages (mAM)	504:543	However, it is unclear whether cell isolation procedures affect ex vivo particle-induced responses in primary mouse alveolar macrophages (mAM).
34761701	8	68	theme	Expression	1190:1199	arg1	levels					1201:1206	Expression levels	1190:1206	Expression levels of cell surface markers like CD11c, SiglecF, and CD64	1190:1260	Expression levels of cell surface markers like CD11c, SiglecF, and CD64 did not differ among mAM obtained from BALF collected using the different injection buffer volumes.
34761701	4	69	theme	bronchoalveolar	612:626	arg1	lavage					628:633	bronchoalveolar lavage	612:633	bronchoalveolar lavage fluid (BALF) collection	612:657	In this study, effects of injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses were assessed.
34761701	0	70	theme	fluid	68:72	arg1	collection					74:83	bronchoalveolar lavage fluid collection	45:83	bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion	45:171	Impact of injection buffer volume to perform bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion.
34761701	3	71	theme	particle-induced	474:489	arg1	responses					491:499	ex vivo particle-induced responses	466:499	ex vivo particle-induced responses	466:499	However, it is unclear whether cell isolation procedures affect ex vivo particle-induced responses in primary mouse alveolar macrophages (mAM).
34761701	4	72	theme	ex	685:686	arg1	responses					710:718	ex vivo particle-induced responses	685:718	ex vivo particle-induced responses	685:718	In this study, effects of injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses were assessed.
34761701	3	73	theme	ex	466:467	arg1	responses					491:499	ex vivo particle-induced responses	466:499	ex vivo particle-induced responses	466:499	However, it is unclear whether cell isolation procedures affect ex vivo particle-induced responses in primary mouse alveolar macrophages (mAM).
34761701	0	74	theme	lavage	61:66	arg1	fluid					68:72	bronchoalveolar lavage fluid	45:72	bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion	45:171	Impact of injection buffer volume to perform bronchoalveolar lavage fluid collection for isolating alveolar macrophages to investigate fine particle-induced IL-1α secretion.
34761701	3	75	theme	cell	433:436	arg1	procedures					448:457	cell isolation procedures	433:457	cell isolation procedures	433:457	However, it is unclear whether cell isolation procedures affect ex vivo particle-induced responses in primary mouse alveolar macrophages (mAM).
34761701	9	76	dep	ex	1410:1411	arg1	vivoparticle					1413:1424	vivoparticle	1413:1424	vivoparticle	1413:1424	IL-1α release (and also necroptosis) induced by ex vivoparticle stimulation was suppressed by RIPK3 inhibitor or cytochalasin D co-treatment.
34761701	2	77	theme	fine	386:389	arg1	particles					391:399	fine particles	386:399	fine particles	386:399	Alveolar macrophages release interleukin (IL)-1α as a damage-associated molecular pattern (DAMP) when stimulated by fine particles.
34761701	4	78	theme	fluid	635:639	arg1	collection					648:657	bronchoalveolar lavage fluid (BALF) collection	612:657	bronchoalveolar lavage fluid (BALF) collection	612:657	In this study, effects of injection buffer volume used to perform bronchoalveolar lavage fluid (BALF) collection to isolate mAM for use in ex vivo particle-induced responses were assessed.
34794448	8	0	used	used	1778:1781	arg2	elements					1757:1764	the genetic elements	1745:1764	the genetic elements that can be used to engineer de novo or enhanced biomineralisation	1745:1831	CONCLUSIONS Our findings give insights into the molecular mechanisms driving MICP in an application-relevant chassis organism and the genetic elements that can be used to engineer de novo or enhanced biomineralisation.
34794448	2	1	theme	extracellular	369:381	arg1	environment					383:393	the extracellular environment	365:393	the extracellular environment	365:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	5	2	from	increases	1018:1026	arg1	pH					1045:1046	extracellular pH	1031:1046	extracellular pH	1031:1046	We showed that heterologous production of urease can induce MICP by local increases in extracellular pH, and this can be enhanced by co-expression of urease accessory genes for urea and nickel uptake, depending on environmental conditions.
34794448	2	3	theme	metabolism	304:313	arg1	combination					330:340	a combination	328:340	a combination of chemical changes in the extracellular environment	328:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	3	theme	metabolism	304:313	arg1	increase					404:411	e.g. pH increase	396:411	e.g. pH increase	396:411	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	3	theme	metabolism	304:313	arg1	presence					418:425	presence	418:425	presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria	418:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	3	theme	metabolism	304:313	arg1	by-product					280:289	a by-product	278:289	a by-product of bacterial metabolism	278:313	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	4	4	theme	intrinsic	896:904	arg1	activity					911:918	no detectable intrinsic MICP activity	882:918	no detectable intrinsic MICP activity	882:918	RESULTS In this study, we adopted a bottom-up approach of systematically engineering Bacillus subtilis, which has no detectable intrinsic MICP activity, for biomineralisation.
34794448	6	5	theme	biofilm-promoting	1217:1233	arg1	conditions					1235:1244	biofilm-promoting conditions	1217:1244	biofilm-promoting conditions	1217:1244	MICP can be strongly enhanced by biofilm-promoting conditions, which appeared to be mainly driven by production of exopolysaccharide, while the protein component of the biofilm matrix was dispensable.
34794448	7	6	theme	minor	1462:1466	arg1	effects					1468:1474	surprisingly minor effects	1449:1474	surprisingly minor effects	1449:1474	Attempts to modulate the cell surface charge of B. subtilis had surprisingly minor effects, and our results suggest this organism may intrinsically have a very negative cell surface, potentially predisposing it for MICP activity.
34794448	1	7	theme	considerable	207:218	arg1	attention					220:228	considerable attention	207:228	considerable attention	207:228	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	7	8	theme	B.	1433:1434	arg1	charge					1423:1428	the cell surface charge	1406:1428	the cell surface charge of B. subtilis had surprisingly minor effects	1406:1474	Attempts to modulate the cell surface charge of B. subtilis had surprisingly minor effects, and our results suggest this organism may intrinsically have a very negative cell surface, potentially predisposing it for MICP activity.
34794448	9	9	theme	MICP	2048:2051	arg1	crystals					2036:2043	mineral crystals	2028:2043	mineral crystals of MICP	2028:2051	This study also highlights mutual influences between the genetic drivers and the chemical composition of the surrounding environment in determining the speed, spatial distribution and resulting mineral crystals of MICP.
34794448	6	10	theme	matrix	1361:1366	arg1	component					1336:1344	the protein component	1324:1344	the protein component of the biofilm matrix	1324:1366	MICP can be strongly enhanced by biofilm-promoting conditions, which appeared to be mainly driven by production of exopolysaccharide, while the protein component of the biofilm matrix was dispensable.
34794448	6	10	theme	matrix	1361:1366	arg1	dispensable					1372:1382	dispensable	1372:1382	dispensable	1372:1382	MICP can be strongly enhanced by biofilm-promoting conditions, which appeared to be mainly driven by production of exopolysaccharide, while the protein component of the biofilm matrix was dispensable.
34794448	8	11	dep	CONCLUSIONS	1615:1625	arg1	give					1640:1643	give	1640:1643	give insights into the molecular mechanisms driving MICP in an application-relevant chassis organism and the genetic elements that can be used to engineer de novo or enhanced biomineralisation	1640:1831	CONCLUSIONS Our findings give insights into the molecular mechanisms driving MICP in an application-relevant chassis organism and the genetic elements that can be used to engineer de novo or enhanced biomineralisation.
34794448	9	12	dep	speed	1986:1990	arg1	spatial					1993:1999	spatial	1993:1999	spatial	1993:1999	This study also highlights mutual influences between the genetic drivers and the chemical composition of the surrounding environment in determining the speed, spatial distribution and resulting mineral crystals of MICP.
34794448	7	13	theme	cell	1410:1413	arg1	charge					1423:1428	the cell surface charge	1406:1428	the cell surface charge of B. subtilis had surprisingly minor effects	1406:1474	Attempts to modulate the cell surface charge of B. subtilis had surprisingly minor effects, and our results suggest this organism may intrinsically have a very negative cell surface, potentially predisposing it for MICP activity.
34794448	5	14	theme	accessory	1101:1109	arg1	genes					1111:1115	urease accessory genes	1094:1115	urease accessory genes for urea and nickel uptake	1094:1142	We showed that heterologous production of urease can induce MICP by local increases in extracellular pH, and this can be enhanced by co-expression of urease accessory genes for urea and nickel uptake, depending on environmental conditions.
34794448	5	15	theme	environmental	1158:1170	arg1	conditions					1172:1181	environmental conditions	1158:1181	environmental conditions	1158:1181	We showed that heterologous production of urease can induce MICP by local increases in extracellular pH, and this can be enhanced by co-expression of urease accessory genes for urea and nickel uptake, depending on environmental conditions.
34794448	4	16	contain	has	878:880	arg1	subtilis					862:869	systematically engineering Bacillus subtilis	826:869	systematically engineering Bacillus subtilis	826:869	RESULTS In this study, we adopted a bottom-up approach of systematically engineering Bacillus subtilis, which has no detectable intrinsic MICP activity, for biomineralisation.
34794448	4	16	contain	has	878:880	arg2	activity					911:918	no detectable intrinsic MICP activity	882:918	no detectable intrinsic MICP activity	882:918	RESULTS In this study, we adopted a bottom-up approach of systematically engineering Bacillus subtilis, which has no detectable intrinsic MICP activity, for biomineralisation.
34794448	5	17	theme	heterologous	959:970	arg1	production					972:981	heterologous production	959:981	heterologous production of urease	959:991	We showed that heterologous production of urease can induce MICP by local increases in extracellular pH, and this can be enhanced by co-expression of urease accessory genes for urea and nickel uptake, depending on environmental conditions.
34794448	4	18	theme	bottom-up	804:812	arg1	approach					814:821	a bottom-up approach	802:821	a bottom-up approach of systematically engineering Bacillus subtilis, which has no detectable intrinsic MICP activity, for biomineralisation	802:941	RESULTS In this study, we adopted a bottom-up approach of systematically engineering Bacillus subtilis, which has no detectable intrinsic MICP activity, for biomineralisation.
34794448	10	19	theme	rational	2105:2112	arg1	design					2114:2119	future rational design	2098:2119	future rational design of synthetic precipitator strains optimised for specific applications	2098:2189	Taken together, these data pave the way for future rational design of synthetic precipitator strains optimised for specific applications.
34794448	2	20	from	substances	484:493	arg1	combination					330:340	a combination	328:340	a combination of chemical changes in the extracellular environment	328:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	20	from	substances	484:493	arg1	increase					404:411	e.g. pH increase	396:411	e.g. pH increase	396:411	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	20	from	substances	484:493	arg1	presence					418:425	presence	418:425	presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria	418:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	20	from	substances	484:493	arg1	by-product					280:289	a by-product	278:289	a by-product of bacterial metabolism	278:313	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	0	21	theme	Genetic	0:6	arg1	optimisation					8:19	Genetic optimisation	0:19	Genetic optimisation of bacteria-induced calcite precipitation in Bacillus subtilis	0:82	Genetic optimisation of bacteria-induced calcite precipitation in Bacillus subtilis.
34794448	1	22	theme	calcite	116:122	arg1	property					159:166	an ancient property	148:166	an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications	148:262	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	1	22	theme	calcite	116:122	arg1	MICP					139:142	MICP	139:142	MICP	139:142	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	1	22	theme	calcite	116:122	arg1	precipitation					124:136	BACKGROUND Microbially induced calcite precipitation	85:136	BACKGROUND Microbially induced calcite precipitation (MICP)	85:143	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	2	23	theme	sites	441:445	arg1	combination					330:340	a combination	328:340	a combination of chemical changes in the extracellular environment	328:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	23	theme	sites	441:445	arg1	increase					404:411	e.g. pH increase	396:411	e.g. pH increase	396:411	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	23	theme	sites	441:445	arg1	presence					418:425	presence	418:425	presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria	418:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	23	theme	sites	441:445	arg1	by-product					280:289	a by-product	278:289	a by-product of bacterial metabolism	278:313	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	5	24	theme	local	1012:1016	arg1	increases					1018:1026	local increases	1012:1026	local increases in extracellular pH	1012:1046	We showed that heterologous production of urease can induce MICP by local increases in extracellular pH, and this can be enhanced by co-expression of urease accessory genes for urea and nickel uptake, depending on environmental conditions.
34794448	1	25	theme	ancient	151:157	arg1	property					159:166	an ancient property	148:166	an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications	148:262	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	1	25	theme	ancient	151:157	arg1	precipitation					124:136	BACKGROUND Microbially induced calcite precipitation	85:136	BACKGROUND Microbially induced calcite precipitation (MICP)	85:143	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	3	26	theme	full	679:682	arg1	exploitation					723:734	the full biotechnological and synthetic biology exploitation	675:734	the full biotechnological and synthetic biology exploitation of bacterial biomineralisation	675:765	However, the molecular mechanisms underpinning MICP and the interplay between the contributing factors remain poorly understood, thus placing barriers to the full biotechnological and synthetic biology exploitation of bacterial biomineralisation.
34794448	0	27	theme	calcite	41:47	arg1	precipitation					49:61	bacteria-induced calcite precipitation	24:61	bacteria-induced calcite precipitation	24:61	Genetic optimisation of bacteria-induced calcite precipitation in Bacillus subtilis.
34794448	2	28	from	increase	404:411	arg1	environment					383:393	the extracellular environment	365:393	the extracellular environment	365:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	28	from	increase	404:411	arg1	surface					459:465	the cell surface	450:465	the cell surface	450:465	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	28	from	increase	404:411	arg1	substances					484:493	extracellular substances	470:493	extracellular substances produced by the bacteria	470:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	29	theme	extracellular	470:482	arg1	substances					484:493	extracellular substances	470:493	extracellular substances produced by the bacteria	470:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	3	30	theme	biology	715:721	arg1	exploitation					723:734	the full biotechnological and synthetic biology exploitation	675:734	the full biotechnological and synthetic biology exploitation of bacterial biomineralisation	675:765	However, the molecular mechanisms underpinning MICP and the interplay between the contributing factors remain poorly understood, thus placing barriers to the full biotechnological and synthetic biology exploitation of bacterial biomineralisation.
34794448	2	31	theme	changes	354:360	arg1	combination					330:340	a combination	328:340	a combination of chemical changes in the extracellular environment	328:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	31	theme	changes	354:360	arg1	increase					404:411	e.g. pH increase	396:411	e.g. pH increase	396:411	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	31	theme	changes	354:360	arg1	presence					418:425	presence	418:425	presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria	418:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	31	theme	changes	354:360	arg1	by-product					280:289	a by-product	278:289	a by-product of bacterial metabolism	278:313	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	8	32	theme	application-relevant	1703:1722	arg1	organism					1732:1739	an application-relevant chassis organism	1700:1739	an application-relevant chassis organism	1700:1739	CONCLUSIONS Our findings give insights into the molecular mechanisms driving MICP in an application-relevant chassis organism and the genetic elements that can be used to engineer de novo or enhanced biomineralisation.
34794448	1	33	theme	biotechnological	234:249	arg1	applications					251:262	biotechnological applications	234:262	biotechnological applications	234:262	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	7	34	theme	negative	1545:1552	arg1	surface					1559:1565	a very negative cell surface	1538:1565	a very negative cell surface	1538:1565	Attempts to modulate the cell surface charge of B. subtilis had surprisingly minor effects, and our results suggest this organism may intrinsically have a very negative cell surface, potentially predisposing it for MICP activity.
34794448	10	35	theme	precipitator	2134:2145	arg1	strains					2147:2153	synthetic precipitator strains	2124:2153	synthetic precipitator strains optimised for specific applications	2124:2189	Taken together, these data pave the way for future rational design of synthetic precipitator strains optimised for specific applications.
34794448	4	36	theme	subtilis	862:869	arg1	approach					814:821	a bottom-up approach	802:821	a bottom-up approach of systematically engineering Bacillus subtilis, which has no detectable intrinsic MICP activity, for biomineralisation	802:941	RESULTS In this study, we adopted a bottom-up approach of systematically engineering Bacillus subtilis, which has no detectable intrinsic MICP activity, for biomineralisation.
34794448	2	37	theme	e.g.	396:399	arg1	combination					330:340	a combination	328:340	a combination of chemical changes in the extracellular environment	328:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	37	theme	e.g.	396:399	arg1	increase					404:411	e.g. pH increase	396:411	e.g. pH increase	396:411	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	37	theme	e.g.	396:399	arg1	presence					418:425	presence	418:425	presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria	418:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	37	theme	e.g.	396:399	arg1	by-product					280:289	a by-product	278:289	a by-product of bacterial metabolism	278:313	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	38	from	sites	441:445	arg1	surface					459:465	the cell surface	450:465	the cell surface	450:465	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	38	from	sites	441:445	arg1	substances					484:493	extracellular substances	470:493	extracellular substances produced by the bacteria	470:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	9	39	theme	environment	1955:1965	arg1	composition					1924:1934	the chemical composition	1911:1934	the chemical composition of the surrounding environment in determining the speed, spatial distribution and resulting mineral crystals of MICP	1911:2051	This study also highlights mutual influences between the genetic drivers and the chemical composition of the surrounding environment in determining the speed, spatial distribution and resulting mineral crystals of MICP.
34794448	9	39	theme	environment	1955:1965	arg1	drivers					1899:1905	the genetic drivers	1887:1905	the genetic drivers	1887:1905	This study also highlights mutual influences between the genetic drivers and the chemical composition of the surrounding environment in determining the speed, spatial distribution and resulting mineral crystals of MICP.
34794448	8	40	theme	molecular	1663:1671	arg1	mechanisms					1673:1682	the molecular mechanisms	1659:1682	the molecular mechanisms driving MICP in an application-relevant chassis organism	1659:1739	CONCLUSIONS Our findings give insights into the molecular mechanisms driving MICP in an application-relevant chassis organism and the genetic elements that can be used to engineer de novo or enhanced biomineralisation.
34794448	3	41	theme	biomineralisation	749:765	arg1	exploitation					723:734	the full biotechnological and synthetic biology exploitation	675:734	the full biotechnological and synthetic biology exploitation of bacterial biomineralisation	675:765	However, the molecular mechanisms underpinning MICP and the interplay between the contributing factors remain poorly understood, thus placing barriers to the full biotechnological and synthetic biology exploitation of bacterial biomineralisation.
34794448	2	42	from	changes	354:360	arg1	environment					383:393	the extracellular environment	365:393	the extracellular environment	365:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	10	43	theme	specific	2169:2176	arg1	applications					2178:2189	specific applications	2169:2189	specific applications	2169:2189	Taken together, these data pave the way for future rational design of synthetic precipitator strains optimised for specific applications.
34794448	6	44	theme	protein	1328:1334	arg1	component					1336:1344	the protein component	1324:1344	the protein component of the biofilm matrix	1324:1366	MICP can be strongly enhanced by biofilm-promoting conditions, which appeared to be mainly driven by production of exopolysaccharide, while the protein component of the biofilm matrix was dispensable.
34794448	6	44	theme	protein	1328:1334	arg1	dispensable					1372:1382	dispensable	1372:1382	dispensable	1372:1382	MICP can be strongly enhanced by biofilm-promoting conditions, which appeared to be mainly driven by production of exopolysaccharide, while the protein component of the biofilm matrix was dispensable.
34794448	9	45	theme	speed	1986:1990	arg1	distribution					2001:2012	the speed, spatial distribution	1982:2012	the speed, spatial distribution	1982:2012	This study also highlights mutual influences between the genetic drivers and the chemical composition of the surrounding environment in determining the speed, spatial distribution and resulting mineral crystals of MICP.
34794448	2	46	theme	bacterial	294:302	arg1	metabolism					304:313	bacterial metabolism	294:313	bacterial metabolism	294:313	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	4	47	theme	detectable	885:894	arg1	activity					911:918	no detectable intrinsic MICP activity	882:918	no detectable intrinsic MICP activity	882:918	RESULTS In this study, we adopted a bottom-up approach of systematically engineering Bacillus subtilis, which has no detectable intrinsic MICP activity, for biomineralisation.
34794448	2	48	from	environment	383:393	arg1	combination					330:340	a combination	328:340	a combination of chemical changes in the extracellular environment	328:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	48	from	environment	383:393	arg1	increase					404:411	e.g. pH increase	396:411	e.g. pH increase	396:411	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	48	from	environment	383:393	arg1	presence					418:425	presence	418:425	presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria	418:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	48	from	environment	383:393	arg1	by-product					280:289	a by-product	278:289	a by-product of bacterial metabolism	278:313	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	6	49	theme	exopolysaccharide	1299:1315	arg1	production					1285:1294	production	1285:1294	production of exopolysaccharide	1285:1315	MICP can be strongly enhanced by biofilm-promoting conditions, which appeared to be mainly driven by production of exopolysaccharide, while the protein component of the biofilm matrix was dispensable.
34794448	7	50	dep	B.	1433:1434	arg1	subtilis					1436:1443	B. subtilis	1433:1443	B. subtilis had surprisingly minor effects	1433:1474	Attempts to modulate the cell surface charge of B. subtilis had surprisingly minor effects, and our results suggest this organism may intrinsically have a very negative cell surface, potentially predisposing it for MICP activity.
34794448	2	51	from	surface	459:465	arg1	combination					330:340	a combination	328:340	a combination of chemical changes in the extracellular environment	328:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	51	from	surface	459:465	arg1	increase					404:411	e.g. pH increase	396:411	e.g. pH increase	396:411	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	51	from	surface	459:465	arg1	presence					418:425	presence	418:425	presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria	418:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	51	from	surface	459:465	arg1	by-product					280:289	a by-product	278:289	a by-product of bacterial metabolism	278:313	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	4	52	theme	MICP	906:909	arg1	activity					911:918	no detectable intrinsic MICP activity	882:918	no detectable intrinsic MICP activity	882:918	RESULTS In this study, we adopted a bottom-up approach of systematically engineering Bacillus subtilis, which has no detectable intrinsic MICP activity, for biomineralisation.
34794448	1	53	theme	bacteria	171:178	arg1	property					159:166	an ancient property	148:166	an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications	148:262	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	1	53	theme	bacteria	171:178	arg1	precipitation					124:136	BACKGROUND Microbially induced calcite precipitation	85:136	BACKGROUND Microbially induced calcite precipitation (MICP)	85:143	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	9	54	theme	mineral	2028:2034	arg1	crystals					2036:2043	mineral crystals	2028:2043	mineral crystals of MICP	2028:2051	This study also highlights mutual influences between the genetic drivers and the chemical composition of the surrounding environment in determining the speed, spatial distribution and resulting mineral crystals of MICP.
34794448	5	55	theme	nickel	1130:1135	arg1	uptake					1137:1142	nickel uptake	1130:1142	nickel uptake	1130:1142	We showed that heterologous production of urease can induce MICP by local increases in extracellular pH, and this can be enhanced by co-expression of urease accessory genes for urea and nickel uptake, depending on environmental conditions.
34794448	3	56	theme	contributing	603:614	arg1	factors					616:622	the contributing factors	599:622	the contributing factors	599:622	However, the molecular mechanisms underpinning MICP and the interplay between the contributing factors remain poorly understood, thus placing barriers to the full biotechnological and synthetic biology exploitation of bacterial biomineralisation.
34794448	8	57	from	MICP	1692:1695	arg1	organism					1732:1739	an application-relevant chassis organism	1700:1739	an application-relevant chassis organism	1700:1739	CONCLUSIONS Our findings give insights into the molecular mechanisms driving MICP in an application-relevant chassis organism and the genetic elements that can be used to engineer de novo or enhanced biomineralisation.
34794448	5	58	theme	urease	1094:1099	arg1	genes					1111:1115	urease accessory genes	1094:1115	urease accessory genes for urea and nickel uptake	1094:1142	We showed that heterologous production of urease can induce MICP by local increases in extracellular pH, and this can be enhanced by co-expression of urease accessory genes for urea and nickel uptake, depending on environmental conditions.
34794448	5	59	theme	urease	986:991	arg1	production					972:981	heterologous production	959:981	heterologous production of urease	959:991	We showed that heterologous production of urease can induce MICP by local increases in extracellular pH, and this can be enhanced by co-expression of urease accessory genes for urea and nickel uptake, depending on environmental conditions.
34794448	7	60	theme	surface	1415:1421	arg1	charge					1423:1428	the cell surface charge	1406:1428	the cell surface charge of B. subtilis had surprisingly minor effects	1406:1474	Attempts to modulate the cell surface charge of B. subtilis had surprisingly minor effects, and our results suggest this organism may intrinsically have a very negative cell surface, potentially predisposing it for MICP activity.
34794448	5	61	theme	genes	1111:1115	arg1	co-expression					1077:1089	co-expression	1077:1089	co-expression of urease accessory genes for urea and nickel uptake	1077:1142	We showed that heterologous production of urease can induce MICP by local increases in extracellular pH, and this can be enhanced by co-expression of urease accessory genes for urea and nickel uptake, depending on environmental conditions.
34794448	7	62	contain	have	1533:1536	arg1	organism					1506:1513	this organism	1501:1513	this organism	1501:1513	Attempts to modulate the cell surface charge of B. subtilis had surprisingly minor effects, and our results suggest this organism may intrinsically have a very negative cell surface, potentially predisposing it for MICP activity.
34794448	7	62	contain	have	1533:1536	arg2	surface					1559:1565	a very negative cell surface	1538:1565	a very negative cell surface	1538:1565	Attempts to modulate the cell surface charge of B. subtilis had surprisingly minor effects, and our results suggest this organism may intrinsically have a very negative cell surface, potentially predisposing it for MICP activity.
34794448	0	63	from	optimisation	8:19	arg1	subtilis					75:82	Bacillus subtilis	66:82	Bacillus subtilis	66:82	Genetic optimisation of bacteria-induced calcite precipitation in Bacillus subtilis.
34794448	2	64	from	combination	330:340	arg1	environment					383:393	the extracellular environment	365:393	the extracellular environment	365:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	64	from	combination	330:340	arg1	surface					459:465	the cell surface	450:465	the cell surface	450:465	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	64	from	combination	330:340	arg1	substances					484:493	extracellular substances	470:493	extracellular substances produced by the bacteria	470:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	7	65	theme	MICP	1600:1603	arg1	activity					1605:1612	MICP activity	1600:1612	MICP activity	1600:1612	Attempts to modulate the cell surface charge of B. subtilis had surprisingly minor effects, and our results suggest this organism may intrinsically have a very negative cell surface, potentially predisposing it for MICP activity.
34794448	10	66	theme	future	2098:2103	arg1	design					2114:2119	future rational design	2098:2119	future rational design of synthetic precipitator strains optimised for specific applications	2098:2189	Taken together, these data pave the way for future rational design of synthetic precipitator strains optimised for specific applications.
34794448	1	67	theme	BACKGROUND	85:94	arg1	property					159:166	an ancient property	148:166	an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications	148:262	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	1	67	theme	BACKGROUND	85:94	arg1	MICP					139:142	MICP	139:142	MICP	139:142	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	1	67	theme	BACKGROUND	85:94	arg1	precipitation					124:136	BACKGROUND Microbially induced calcite precipitation	85:136	BACKGROUND Microbially induced calcite precipitation (MICP)	85:143	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	9	68	theme	mutual	1861:1866	arg1	influences					1868:1877	mutual influences	1861:1877	mutual influences between the genetic drivers and the chemical composition of the surrounding environment in determining the speed, spatial distribution and resulting mineral crystals of MICP	1861:2051	This study also highlights mutual influences between the genetic drivers and the chemical composition of the surrounding environment in determining the speed, spatial distribution and resulting mineral crystals of MICP.
34794448	1	69	theme	induced	108:114	arg1	property					159:166	an ancient property	148:166	an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications	148:262	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	1	69	theme	induced	108:114	arg1	MICP					139:142	MICP	139:142	MICP	139:142	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	1	69	theme	induced	108:114	arg1	precipitation					124:136	BACKGROUND Microbially induced calcite precipitation	85:136	BACKGROUND Microbially induced calcite precipitation (MICP)	85:143	BACKGROUND Microbially induced calcite precipitation (MICP) is an ancient property of bacteria, which has recently gained considerable attention for biotechnological applications.
34794448	2	70	theme	cell	454:457	arg1	surface					459:465	the cell surface	450:465	the cell surface	450:465	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	71	theme	pH	401:402	arg1	combination					330:340	a combination	328:340	a combination of chemical changes in the extracellular environment	328:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	71	theme	pH	401:402	arg1	increase					404:411	e.g. pH increase	396:411	e.g. pH increase	396:411	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	71	theme	pH	401:402	arg1	presence					418:425	presence	418:425	presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria	418:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	71	theme	pH	401:402	arg1	by-product					280:289	a by-product	278:289	a by-product of bacterial metabolism	278:313	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	0	72	theme	bacteria-induced	24:39	arg1	precipitation					49:61	bacteria-induced calcite precipitation	24:61	bacteria-induced calcite precipitation	24:61	Genetic optimisation of bacteria-induced calcite precipitation in Bacillus subtilis.
34794448	6	73	theme	biofilm	1353:1359	arg1	matrix					1361:1366	the biofilm matrix	1349:1366	the biofilm matrix	1349:1366	MICP can be strongly enhanced by biofilm-promoting conditions, which appeared to be mainly driven by production of exopolysaccharide, while the protein component of the biofilm matrix was dispensable.
34794448	4	74	dep	RESULTS	768:774	arg1	adopted					794:800	adopted	794:800	adopted a bottom-up approach of systematically engineering Bacillus subtilis, which has no detectable intrinsic MICP activity, for biomineralisation	794:941	RESULTS In this study, we adopted a bottom-up approach of systematically engineering Bacillus subtilis, which has no detectable intrinsic MICP activity, for biomineralisation.
34794448	9	75	theme	genetic	1891:1897	arg1	drivers					1899:1905	the genetic drivers	1887:1905	the genetic drivers	1887:1905	This study also highlights mutual influences between the genetic drivers and the chemical composition of the surrounding environment in determining the speed, spatial distribution and resulting mineral crystals of MICP.
34794448	5	76	theme	extracellular	1031:1043	arg1	pH					1045:1046	extracellular pH	1031:1046	extracellular pH	1031:1046	We showed that heterologous production of urease can induce MICP by local increases in extracellular pH, and this can be enhanced by co-expression of urease accessory genes for urea and nickel uptake, depending on environmental conditions.
34794448	2	77	theme	nucleation	430:439	arg1	sites					441:445	nucleation sites	430:445	nucleation sites on the cell surface or extracellular substances produced by the bacteria	430:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	0	78	theme	precipitation	49:61	arg1	optimisation					8:19	Genetic optimisation	0:19	Genetic optimisation of bacteria-induced calcite precipitation in Bacillus subtilis	0:82	Genetic optimisation of bacteria-induced calcite precipitation in Bacillus subtilis.
34794448	10	79	theme	synthetic	2124:2132	arg1	strains					2147:2153	synthetic precipitator strains	2124:2153	synthetic precipitator strains optimised for specific applications	2124:2189	Taken together, these data pave the way for future rational design of synthetic precipitator strains optimised for specific applications.
34794448	9	80	theme	chemical	1915:1922	arg1	composition					1924:1934	the chemical composition	1911:1934	the chemical composition of the surrounding environment in determining the speed, spatial distribution and resulting mineral crystals of MICP	1911:2051	This study also highlights mutual influences between the genetic drivers and the chemical composition of the surrounding environment in determining the speed, spatial distribution and resulting mineral crystals of MICP.
34794448	3	81	theme	synthetic	705:713	arg1	exploitation					723:734	the full biotechnological and synthetic biology exploitation	675:734	the full biotechnological and synthetic biology exploitation of bacterial biomineralisation	675:765	However, the molecular mechanisms underpinning MICP and the interplay between the contributing factors remain poorly understood, thus placing barriers to the full biotechnological and synthetic biology exploitation of bacterial biomineralisation.
34794448	8	82	theme	chassis	1724:1730	arg1	organism					1732:1739	an application-relevant chassis organism	1700:1739	an application-relevant chassis organism	1700:1739	CONCLUSIONS Our findings give insights into the molecular mechanisms driving MICP in an application-relevant chassis organism and the genetic elements that can be used to engineer de novo or enhanced biomineralisation.
34794448	10	83	theme	strains	2147:2153	arg1	design					2114:2119	future rational design	2098:2119	future rational design of synthetic precipitator strains optimised for specific applications	2098:2189	Taken together, these data pave the way for future rational design of synthetic precipitator strains optimised for specific applications.
34794448	3	84	theme	biotechnological	684:699	arg1	exploitation					723:734	the full biotechnological and synthetic biology exploitation	675:734	the full biotechnological and synthetic biology exploitation of bacterial biomineralisation	675:765	However, the molecular mechanisms underpinning MICP and the interplay between the contributing factors remain poorly understood, thus placing barriers to the full biotechnological and synthetic biology exploitation of bacterial biomineralisation.
34794448	2	85	theme	chemical	345:352	arg1	changes					354:360	chemical changes	345:360	chemical changes in the extracellular environment	345:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	7	86	theme	cell	1554:1557	arg1	surface					1559:1565	a very negative cell surface	1538:1565	a very negative cell surface	1538:1565	Attempts to modulate the cell surface charge of B. subtilis had surprisingly minor effects, and our results suggest this organism may intrinsically have a very negative cell surface, potentially predisposing it for MICP activity.
34794448	2	87	from	presence	418:425	arg1	environment					383:393	the extracellular environment	365:393	the extracellular environment	365:393	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	87	from	presence	418:425	arg1	surface					459:465	the cell surface	450:465	the cell surface	450:465	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	2	87	from	presence	418:425	arg1	substances					484:493	extracellular substances	470:493	extracellular substances produced by the bacteria	470:518	It occurs as a by-product of bacterial metabolism and involves a combination of chemical changes in the extracellular environment, e.g. pH increase, and presence of nucleation sites on the cell surface or extracellular substances produced by the bacteria.
34794448	9	88	theme	surrounding	1943:1953	arg1	environment					1955:1965	the surrounding environment	1939:1965	the surrounding environment	1939:1965	This study also highlights mutual influences between the genetic drivers and the chemical composition of the surrounding environment in determining the speed, spatial distribution and resulting mineral crystals of MICP.
34794448	3	89	theme	bacterial	739:747	arg1	biomineralisation					749:765	bacterial biomineralisation	739:765	bacterial biomineralisation	739:765	However, the molecular mechanisms underpinning MICP and the interplay between the contributing factors remain poorly understood, thus placing barriers to the full biotechnological and synthetic biology exploitation of bacterial biomineralisation.
34794448	3	90	theme	molecular	534:542	arg1	mechanisms					544:553	the molecular mechanisms	530:553	the molecular mechanisms underpinning MICP	530:571	However, the molecular mechanisms underpinning MICP and the interplay between the contributing factors remain poorly understood, thus placing barriers to the full biotechnological and synthetic biology exploitation of bacterial biomineralisation.
34794448	8	91	theme	genetic	1749:1755	arg1	elements					1757:1764	the genetic elements	1745:1764	the genetic elements that can be used to engineer de novo or enhanced biomineralisation	1745:1831	CONCLUSIONS Our findings give insights into the molecular mechanisms driving MICP in an application-relevant chassis organism and the genetic elements that can be used to engineer de novo or enhanced biomineralisation.
32729518	5	0	theme	glassy	772:777	arg1	GCE					797:799	GCE	797:799	GCE	797:799	A glassy carbon electrode (GCE) is chemically modified using CD-CuMOF and carbon nanofibers (CNF) composite material to construct a sensor in the form of (CD-CuMOF-CNF-GCE).
32729518	5	0	theme	glassy	772:777	arg1	electrode					786:794	A glassy carbon electrode	770:794	A glassy carbon electrode (GCE)	770:800	A glassy carbon electrode (GCE) is chemically modified using CD-CuMOF and carbon nanofibers (CNF) composite material to construct a sensor in the form of (CD-CuMOF-CNF-GCE).
32729518	7	1	theme	potential	1169:1177	arg1	difference					1179:1188	excellent peak potential difference	1154:1188	excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture	1154:1292	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	7	1	theme	potential	1169:1177	arg1	 = 108 mV					1202:1210	ΔEp (SS-RR) = 108 mV	1191:1210	ΔEp (SS-RR) = 108 mV	1191:1210	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	6	2	theme	CD-CuMOF	961:968	arg1	model					1034:1038	an artificial enzyme model	1013:1038	an artificial enzyme model (AEM)	1013:1044	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	6	2	theme	CD-CuMOF	961:968	arg1	behaviour					948:956	The behaviour	944:956	The behaviour of CD-CuMOF for ETB isomers on GCE	944:991	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	2	3	from	determination	320:332	arg1	samples					364:370	racemic and pharmaceutical samples	337:370	racemic and pharmaceutical samples	337:370	Therefore, its determination in racemic and pharmaceutical samples becomes a challenge.
32729518	1	4	theme	environment	275:285	arg1	presence					256:263	presence	256:263	presence of chiral environment for human beings	256:302	Stereochemical configuration of the drug is responsible for racemic switch with enantiomers in presence of chiral environment for human beings.
32729518	0	5	theme	organic	87:93	arg1	framework					95:103	chiral copper metal organic framework	67:103	chiral copper metal organic framework	67:103	Biomimetic sensor for ethambutol employing β-cyclodextrin mediated chiral copper metal organic framework and carbon nanofibers modified glassy carbon electrode.
32729518	7	6	from	distinction	1259:1269	arg1	mixture					1286:1292	the racemic mixture	1274:1292	the racemic mixture	1274:1292	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	7	7	theme	SS-RR	1196:1200	arg1	difference					1179:1188	excellent peak potential difference	1154:1188	excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture	1154:1292	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	7	7	theme	SS-RR	1196:1200	arg1	 = 108 mV					1202:1210	ΔEp (SS-RR) = 108 mV	1191:1210	ΔEp (SS-RR) = 108 mV	1191:1210	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	6	8	theme	ETB	974:976	arg1	isomers					978:984	ETB isomers	974:984	ETB isomers	974:984	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	0	9	theme	carbon	109:114	arg1	electrode					150:158	carbon nanofibers modified glassy carbon electrode	109:158	carbon nanofibers modified glassy carbon electrode	109:158	Biomimetic sensor for ethambutol employing β-cyclodextrin mediated chiral copper metal organic framework and carbon nanofibers modified glassy carbon electrode.
32729518	8	10	theme	10-4 M	1388:1393	arg1	range					1330:1334	the range	1326:1334	the range of 1.0 x 10-7 to 1 x 10-4 M and 5.0 x 10-7 to 2.5 x 10-4 M	1326:1393	It showed a linear response in the range of 1.0 x 10-7 to 1 x 10-4 M and 5.0 x 10-7 to 2.5 x 10-4 M with low detection limit of 3.10 x 10-8 M and 8.52 x 10-8 M for RR-ETB and SS-ETB isomers respectively.
32729518	1	11	theme	human	291:295	arg1	beings					297:302	human beings	291:302	human beings	291:302	Stereochemical configuration of the drug is responsible for racemic switch with enantiomers in presence of chiral environment for human beings.
32729518	7	12	theme	peak	1164:1167	arg1	difference					1179:1188	excellent peak potential difference	1154:1188	excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture	1154:1292	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	7	12	theme	peak	1164:1167	arg1	 = 108 mV					1202:1210	ΔEp (SS-RR) = 108 mV	1191:1210	ΔEp (SS-RR) = 108 mV	1191:1210	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	6	13	theme	alcohol	1100:1106	arg1	dehydrogenase					1108:1120	enzyme alcohol dehydrogenase	1093:1120	enzyme alcohol dehydrogenase for ETB	1093:1128	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	3	14	theme	first	580:584	arg1	time					586:589	the first time	576:589	the first time	576:589	Addressing this issue, an enantioselective electrochemical biomimetic sensor for discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV) is reported for the first time.
32729518	2	15	theme	pharmaceutical	349:362	arg1	samples					364:370	racemic and pharmaceutical samples	337:370	racemic and pharmaceutical samples	337:370	Therefore, its determination in racemic and pharmaceutical samples becomes a challenge.
32729518	0	16	theme	modified	127:134	arg1	electrode					150:158	carbon nanofibers modified glassy carbon electrode	109:158	carbon nanofibers modified glassy carbon electrode	109:158	Biomimetic sensor for ethambutol employing β-cyclodextrin mediated chiral copper metal organic framework and carbon nanofibers modified glassy carbon electrode.
32729518	6	17	theme	similar	1082:1088	arg1	activity					1073:1080	the catalytic activity	1059:1080	the catalytic activity similar to enzyme alcohol dehydrogenase for ETB	1059:1128	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	8	18	theme	detection	1404:1412	arg1	limit					1414:1418	low detection limit	1400:1418	low detection limit of 3.10 x 10-8 M and 8.52 x 10-8 M for RR-ETB and SS-ETB isomers	1400:1483	It showed a linear response in the range of 1.0 x 10-7 to 1 x 10-4 M and 5.0 x 10-7 to 2.5 x 10-4 M with low detection limit of 3.10 x 10-8 M and 8.52 x 10-8 M for RR-ETB and SS-ETB isomers respectively.
32729518	10	19	with	material	1658:1665	arg1	stability					1679:1687	higher stability	1672:1687	higher stability than enzyme	1672:1699	The CD-CuMOF is a low-cost material with higher stability than enzyme and offers an advantage for sensing and catalysis in future.
32729518	1	20	theme	drug	197:200	arg1	configuration					176:188	Stereochemical configuration	161:188	Stereochemical configuration of the drug	161:200	Stereochemical configuration of the drug is responsible for racemic switch with enantiomers in presence of chiral environment for human beings.
32729518	0	21	theme	nanofibers	116:125	arg1	electrode					150:158	carbon nanofibers modified glassy carbon electrode	109:158	carbon nanofibers modified glassy carbon electrode	109:158	Biomimetic sensor for ethambutol employing β-cyclodextrin mediated chiral copper metal organic framework and carbon nanofibers modified glassy carbon electrode.
32729518	6	22	theme	catalytic	1063:1071	arg1	activity					1073:1080	the catalytic activity	1059:1080	the catalytic activity similar to enzyme alcohol dehydrogenase for ETB	1059:1128	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	4	23	used	used	708:711	arg2	β-Cyclodextrin					625:638	a chiral host, β-Cyclodextrin	610:638	β-Cyclodextrin	625:638	For this purpose, a chiral host, β-Cyclodextrin based copper metal organic framework (CD-CuMOF) was synthesized and used for chelate complexation of ETB isomers (SS-ETB/RR-ETB).
32729518	3	24	theme	enantioselective	419:434	arg1	sensor					463:468	an enantioselective electrochemical biomimetic sensor	416:468	an enantioselective electrochemical biomimetic sensor for discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV)	416:558	Addressing this issue, an enantioselective electrochemical biomimetic sensor for discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV) is reported for the first time.
32729518	5	25	theme	carbon	779:784	arg1	GCE					797:799	GCE	797:799	GCE	797:799	A glassy carbon electrode (GCE) is chemically modified using CD-CuMOF and carbon nanofibers (CNF) composite material to construct a sensor in the form of (CD-CuMOF-CNF-GCE).
32729518	5	25	theme	carbon	779:784	arg1	electrode					786:794	A glassy carbon electrode	770:794	A glassy carbon electrode (GCE)	770:800	A glassy carbon electrode (GCE) is chemically modified using CD-CuMOF and carbon nanofibers (CNF) composite material to construct a sensor in the form of (CD-CuMOF-CNF-GCE).
32729518	9	26	theme	ETB	1544:1546	arg1	isomers					1548:1554	ETB isomers	1544:1554	ETB isomers	1544:1554	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	8	27	theme	low	1400:1402	arg1	limit					1414:1418	low detection limit	1400:1418	low detection limit of 3.10 x 10-8 M and 8.52 x 10-8 M for RR-ETB and SS-ETB isomers	1400:1483	It showed a linear response in the range of 1.0 x 10-7 to 1 x 10-4 M and 5.0 x 10-7 to 2.5 x 10-4 M with low detection limit of 3.10 x 10-8 M and 8.52 x 10-8 M for RR-ETB and SS-ETB isomers respectively.
32729518	7	28	theme	clear	1253:1257	arg1	distinction					1259:1269	a clear distinction	1251:1269	a clear distinction in the racemic mixture	1251:1292	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	0	29	theme	Biomimetic	0:9	arg1	sensor					11:16	Biomimetic sensor	0:16	Biomimetic sensor for ethambutol employing β-cyclodextrin	0:56	Biomimetic sensor for ethambutol employing β-cyclodextrin mediated chiral copper metal organic framework and carbon nanofibers modified glassy carbon electrode.
32729518	9	30	theme	isomers	1548:1554	arg1	estimation					1530:1539	the estimation	1526:1539	the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical	1526:1628	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	5	31	from	sensor	902:907	arg1	form					916:919	the form	912:919	the form of (CD-CuMOF-CNF-GCE)	912:941	A glassy carbon electrode (GCE) is chemically modified using CD-CuMOF and carbon nanofibers (CNF) composite material to construct a sensor in the form of (CD-CuMOF-CNF-GCE).
32729518	2	32	theme	racemic	337:343	arg1	samples					364:370	racemic and pharmaceutical samples	337:370	racemic and pharmaceutical samples	337:370	Therefore, its determination in racemic and pharmaceutical samples becomes a challenge.
32729518	9	33	dep	samples	1584:1590	arg1	urine					1605:1609	urine	1605:1609	urine	1605:1609	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	9	33	dep	samples	1584:1590	arg1	samples					1584:1590	real samples viz., blood, urine and pharmaceutical	1579:1628	real samples viz., blood, urine and pharmaceutical	1579:1628	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	9	33	dep	samples	1584:1590	arg1	blood					1598:1602	blood	1598:1602	blood	1598:1602	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	9	33	dep	samples	1584:1590	arg1	viz.					1592:1595	viz.	1592:1595	viz.	1592:1595	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	9	33	dep	samples	1584:1590	arg1	pharmaceutical					1615:1628	pharmaceutical	1615:1628	pharmaceutical	1615:1628	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	5	34	theme	composite	868:876	arg1	material					878:885	composite material	868:885	composite material	868:885	A glassy carbon electrode (GCE) is chemically modified using CD-CuMOF and carbon nanofibers (CNF) composite material to construct a sensor in the form of (CD-CuMOF-CNF-GCE).
32729518	10	35	theme	higher	1672:1677	arg1	stability					1679:1687	higher stability	1672:1687	higher stability than enzyme	1672:1699	The CD-CuMOF is a low-cost material with higher stability than enzyme and offers an advantage for sensing and catalysis in future.
32729518	0	36	theme	carbon	143:148	arg1	electrode					150:158	carbon nanofibers modified glassy carbon electrode	109:158	carbon nanofibers modified glassy carbon electrode	109:158	Biomimetic sensor for ethambutol employing β-cyclodextrin mediated chiral copper metal organic framework and carbon nanofibers modified glassy carbon electrode.
32729518	5	37	theme	CD-CuMOF-CNF-GCE	925:940	arg1	form					916:919	the form	912:919	the form of (CD-CuMOF-CNF-GCE)	912:941	A glassy carbon electrode (GCE) is chemically modified using CD-CuMOF and carbon nanofibers (CNF) composite material to construct a sensor in the form of (CD-CuMOF-CNF-GCE).
32729518	1	38	theme	racemic	221:227	arg1	switch					229:234	racemic switch	221:234	racemic switch with enantiomers in presence of chiral environment for human beings	221:302	Stereochemical configuration of the drug is responsible for racemic switch with enantiomers in presence of chiral environment for human beings.
32729518	4	39	theme	isomers	745:751	arg1	complexation					725:736	chelate complexation	717:736	chelate complexation of ETB isomers (SS-ETB/RR-ETB)	717:767	For this purpose, a chiral host, β-Cyclodextrin based copper metal organic framework (CD-CuMOF) was synthesized and used for chelate complexation of ETB isomers (SS-ETB/RR-ETB).
32729518	9	40	from	estimation	1530:1539	arg1	mixture					1567:1573	racemic mixture	1559:1573	racemic mixture	1559:1573	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	9	40	from	estimation	1530:1539	arg1	samples					1584:1590	real samples viz., blood, urine and pharmaceutical	1579:1628	real samples viz., blood, urine and pharmaceutical	1579:1628	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	9	40	from	estimation	1530:1539	arg1	blood					1598:1602	blood	1598:1602	blood	1598:1602	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	9	40	from	estimation	1530:1539	arg1	urine					1605:1609	urine	1605:1609	urine	1605:1609	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	9	40	from	estimation	1530:1539	arg1	viz.					1592:1595	viz.	1592:1595	viz.	1592:1595	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	0	41	theme	glassy	136:141	arg1	electrode					150:158	carbon nanofibers modified glassy carbon electrode	109:158	carbon nanofibers modified glassy carbon electrode	109:158	Biomimetic sensor for ethambutol employing β-cyclodextrin mediated chiral copper metal organic framework and carbon nanofibers modified glassy carbon electrode.
32729518	8	42	theme	linear	1307:1312	arg1	response					1314:1321	a linear response	1305:1321	a linear response	1305:1321	It showed a linear response in the range of 1.0 x 10-7 to 1 x 10-4 M and 5.0 x 10-7 to 2.5 x 10-4 M with low detection limit of 3.10 x 10-8 M and 8.52 x 10-8 M for RR-ETB and SS-ETB isomers respectively.
32729518	4	43	theme	copper	646:651	arg1	CD-CuMOF					678:685	CD-CuMOF	678:685	CD-CuMOF	678:685	For this purpose, a chiral host, β-Cyclodextrin based copper metal organic framework (CD-CuMOF) was synthesized and used for chelate complexation of ETB isomers (SS-ETB/RR-ETB).
32729518	4	43	theme	copper	646:651	arg1	framework					667:675	copper metal organic framework	646:675	copper metal organic framework (CD-CuMOF)	646:686	For this purpose, a chiral host, β-Cyclodextrin based copper metal organic framework (CD-CuMOF) was synthesized and used for chelate complexation of ETB isomers (SS-ETB/RR-ETB).
32729518	6	44	from	behaviour	948:956	arg1	GCE					989:991	GCE	989:991	GCE	989:991	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	5	45	theme	carbon	844:849	arg1	CNF					863:865	CNF	863:865	CNF	863:865	A glassy carbon electrode (GCE) is chemically modified using CD-CuMOF and carbon nanofibers (CNF) composite material to construct a sensor in the form of (CD-CuMOF-CNF-GCE).
32729518	5	45	theme	carbon	844:849	arg1	nanofibers					851:860	carbon nanofibers	844:860	carbon nanofibers (CNF)	844:866	A glassy carbon electrode (GCE) is chemically modified using CD-CuMOF and carbon nanofibers (CNF) composite material to construct a sensor in the form of (CD-CuMOF-CNF-GCE).
32729518	6	46	theme	enzyme	1027:1032	arg1	model					1034:1038	an artificial enzyme model	1013:1038	an artificial enzyme model (AEM)	1013:1044	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	6	46	theme	enzyme	1027:1032	arg1	behaviour					948:956	The behaviour	944:956	The behaviour of CD-CuMOF for ETB isomers on GCE	944:991	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	6	46	theme	enzyme	1027:1032	arg1	AEM					1041:1043	AEM	1041:1043	AEM	1041:1043	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	3	47	theme	ethambutol	503:512	arg1	isomers					492:498	isomers	492:498	isomers of ethambutol (ETB) employing square wave voltammetry (SWV)	492:558	Addressing this issue, an enantioselective electrochemical biomimetic sensor for discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV) is reported for the first time.
32729518	3	48	theme	isomers	492:498	arg1	discrimination					474:487	discrimination	474:487	discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV)	474:558	Addressing this issue, an enantioselective electrochemical biomimetic sensor for discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV) is reported for the first time.
32729518	8	49	theme	x	1446:1446	arg1	10-8 M					1448:1453	3.10 x 10-8 M and 8.52 x 10-8 M	1423:1453	3.10 x 10-8 M and 8.52 x 10-8 M	1423:1453	It showed a linear response in the range of 1.0 x 10-7 to 1 x 10-4 M and 5.0 x 10-7 to 2.5 x 10-4 M with low detection limit of 3.10 x 10-8 M and 8.52 x 10-8 M for RR-ETB and SS-ETB isomers respectively.
32729518	1	50	with	switch	229:234	arg1	enantiomers					241:251	enantiomers	241:251	enantiomers	241:251	Stereochemical configuration of the drug is responsible for racemic switch with enantiomers in presence of chiral environment for human beings.
32729518	10	51	theme	low-cost	1649:1656	arg1	material					1658:1665	a low-cost material	1647:1665	a low-cost material with higher stability than enzyme	1647:1699	The CD-CuMOF is a low-cost material with higher stability than enzyme and offers an advantage for sensing and catalysis in future.
32729518	10	51	theme	low-cost	1649:1656	arg1	CD-CuMOF					1635:1642	The CD-CuMOF	1631:1642	The CD-CuMOF	1631:1642	The CD-CuMOF is a low-cost material with higher stability than enzyme and offers an advantage for sensing and catalysis in future.
32729518	4	52	theme	organic	659:665	arg1	CD-CuMOF					678:685	CD-CuMOF	678:685	CD-CuMOF	678:685	For this purpose, a chiral host, β-Cyclodextrin based copper metal organic framework (CD-CuMOF) was synthesized and used for chelate complexation of ETB isomers (SS-ETB/RR-ETB).
32729518	4	52	theme	organic	659:665	arg1	framework					667:675	copper metal organic framework	646:675	copper metal organic framework (CD-CuMOF)	646:686	For this purpose, a chiral host, β-Cyclodextrin based copper metal organic framework (CD-CuMOF) was synthesized and used for chelate complexation of ETB isomers (SS-ETB/RR-ETB).
32729518	0	53	theme	chiral	67:72	arg1	framework					95:103	chiral copper metal organic framework	67:103	chiral copper metal organic framework	67:103	Biomimetic sensor for ethambutol employing β-cyclodextrin mediated chiral copper metal organic framework and carbon nanofibers modified glassy carbon electrode.
32729518	7	54	theme	excellent	1154:1162	arg1	difference					1179:1188	excellent peak potential difference	1154:1188	excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture	1154:1292	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	7	54	theme	excellent	1154:1162	arg1	 = 108 mV					1202:1210	ΔEp (SS-RR) = 108 mV	1191:1210	ΔEp (SS-RR) = 108 mV	1191:1210	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	9	55	theme	real	1579:1582	arg1	urine					1605:1609	urine	1605:1609	urine	1605:1609	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	9	55	theme	real	1579:1582	arg1	samples					1584:1590	real samples viz., blood, urine and pharmaceutical	1579:1628	real samples viz., blood, urine and pharmaceutical	1579:1628	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	9	55	theme	real	1579:1582	arg1	blood					1598:1602	blood	1598:1602	blood	1598:1602	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	9	55	theme	real	1579:1582	arg1	viz.					1592:1595	viz.	1592:1595	viz.	1592:1595	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	7	56	theme	ΔEp	1191:1193	arg1	difference					1179:1188	excellent peak potential difference	1154:1188	excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture	1154:1292	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	7	56	theme	ΔEp	1191:1193	arg1	 = 108 mV					1202:1210	ΔEp (SS-RR) = 108 mV	1191:1210	ΔEp (SS-RR) = 108 mV	1191:1210	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	3	57	theme	wave	537:540	arg1	SWV					555:557	SWV	555:557	SWV	555:557	Addressing this issue, an enantioselective electrochemical biomimetic sensor for discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV) is reported for the first time.
32729518	3	57	theme	wave	537:540	arg1	voltammetry					542:552	square wave voltammetry	530:552	square wave voltammetry (SWV)	530:558	Addressing this issue, an enantioselective electrochemical biomimetic sensor for discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV) is reported for the first time.
32729518	3	58	theme	biomimetic	452:461	arg1	sensor					463:468	an enantioselective electrochemical biomimetic sensor	416:468	an enantioselective electrochemical biomimetic sensor for discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV)	416:558	Addressing this issue, an enantioselective electrochemical biomimetic sensor for discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV) is reported for the first time.
32729518	4	59	theme	chiral	612:617	arg1	β-Cyclodextrin					625:638	a chiral host, β-Cyclodextrin	610:638	β-Cyclodextrin	625:638	For this purpose, a chiral host, β-Cyclodextrin based copper metal organic framework (CD-CuMOF) was synthesized and used for chelate complexation of ETB isomers (SS-ETB/RR-ETB).
32729518	8	60	dep	1	1353:1353	arg1	to					1350:1351	to	1350:1351	to	1350:1351	It showed a linear response in the range of 1.0 x 10-7 to 1 x 10-4 M and 5.0 x 10-7 to 2.5 x 10-4 M with low detection limit of 3.10 x 10-8 M and 8.52 x 10-8 M for RR-ETB and SS-ETB isomers respectively.
32729518	7	61	theme	ETB	1221:1223	arg1	isomers					1225:1231	ETB isomers	1221:1231	ETB isomers using SWV showing a clear distinction in the racemic mixture	1221:1292	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	4	62	theme	chelate	717:723	arg1	complexation					725:736	chelate complexation	717:736	chelate complexation of ETB isomers (SS-ETB/RR-ETB)	717:767	For this purpose, a chiral host, β-Cyclodextrin based copper metal organic framework (CD-CuMOF) was synthesized and used for chelate complexation of ETB isomers (SS-ETB/RR-ETB).
32729518	8	63	theme	10-8 M	1448:1453	arg1	limit					1414:1418	low detection limit	1400:1418	low detection limit of 3.10 x 10-8 M and 8.52 x 10-8 M for RR-ETB and SS-ETB isomers	1400:1483	It showed a linear response in the range of 1.0 x 10-7 to 1 x 10-4 M and 5.0 x 10-7 to 2.5 x 10-4 M with low detection limit of 3.10 x 10-8 M and 8.52 x 10-8 M for RR-ETB and SS-ETB isomers respectively.
32729518	10	64	from	advantage	1715:1723	arg1	future					1754:1759	future	1754:1759	future	1754:1759	The CD-CuMOF is a low-cost material with higher stability than enzyme and offers an advantage for sensing and catalysis in future.
32729518	8	65	dep	2.5	1382:1384	arg1	to					1379:1380	to	1379:1380	to	1379:1380	It showed a linear response in the range of 1.0 x 10-7 to 1 x 10-4 M and 5.0 x 10-7 to 2.5 x 10-4 M with low detection limit of 3.10 x 10-8 M and 8.52 x 10-8 M for RR-ETB and SS-ETB isomers respectively.
32729518	3	66	theme	electrochemical	436:450	arg1	sensor					463:468	an enantioselective electrochemical biomimetic sensor	416:468	an enantioselective electrochemical biomimetic sensor for discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV)	416:558	Addressing this issue, an enantioselective electrochemical biomimetic sensor for discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV) is reported for the first time.
32729518	1	67	from	switch	229:234	arg1	presence					256:263	presence	256:263	presence of chiral environment for human beings	256:302	Stereochemical configuration of the drug is responsible for racemic switch with enantiomers in presence of chiral environment for human beings.
32729518	4	68	theme	ETB	741:743	arg1	SS-ETB/RR-ETB					754:766	SS-ETB/RR-ETB	754:766	SS-ETB/RR-ETB	754:766	For this purpose, a chiral host, β-Cyclodextrin based copper metal organic framework (CD-CuMOF) was synthesized and used for chelate complexation of ETB isomers (SS-ETB/RR-ETB).
32729518	4	68	theme	ETB	741:743	arg1	isomers					745:751	ETB isomers	741:751	ETB isomers (SS-ETB/RR-ETB)	741:767	For this purpose, a chiral host, β-Cyclodextrin based copper metal organic framework (CD-CuMOF) was synthesized and used for chelate complexation of ETB isomers (SS-ETB/RR-ETB).
32729518	6	69	theme	enzyme	1093:1098	arg1	dehydrogenase					1108:1120	enzyme alcohol dehydrogenase	1093:1120	enzyme alcohol dehydrogenase for ETB	1093:1128	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	6	70	theme	artificial	1016:1025	arg1	model					1034:1038	an artificial enzyme model	1013:1038	an artificial enzyme model (AEM)	1013:1044	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	6	70	theme	artificial	1016:1025	arg1	behaviour					948:956	The behaviour	944:956	The behaviour of CD-CuMOF for ETB isomers on GCE	944:991	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	6	70	theme	artificial	1016:1025	arg1	AEM					1041:1043	AEM	1041:1043	AEM	1041:1043	The behaviour of CD-CuMOF for ETB isomers on GCE is postulated to be an artificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogenase for ETB.
32729518	3	71	theme	square	530:535	arg1	SWV					555:557	SWV	555:557	SWV	555:557	Addressing this issue, an enantioselective electrochemical biomimetic sensor for discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV) is reported for the first time.
32729518	3	71	theme	square	530:535	arg1	voltammetry					542:552	square wave voltammetry	530:552	square wave voltammetry (SWV)	530:558	Addressing this issue, an enantioselective electrochemical biomimetic sensor for discrimination of isomers of ethambutol (ETB) employing square wave voltammetry (SWV) is reported for the first time.
32729518	4	72	theme	host	619:622	arg1	β-Cyclodextrin					625:638	a chiral host, β-Cyclodextrin	610:638	β-Cyclodextrin	625:638	For this purpose, a chiral host, β-Cyclodextrin based copper metal organic framework (CD-CuMOF) was synthesized and used for chelate complexation of ETB isomers (SS-ETB/RR-ETB).
32729518	0	73	theme	metal	81:85	arg1	framework					95:103	chiral copper metal organic framework	67:103	chiral copper metal organic framework	67:103	Biomimetic sensor for ethambutol employing β-cyclodextrin mediated chiral copper metal organic framework and carbon nanofibers modified glassy carbon electrode.
32729518	7	74	theme	racemic	1278:1284	arg1	mixture					1286:1292	the racemic mixture	1274:1292	the racemic mixture	1274:1292	The biosensor exhibits excellent peak potential difference (ΔEp (SS-RR) = 108 mV) between ETB isomers using SWV showing a clear distinction in the racemic mixture.
32729518	4	75	theme	metal	653:657	arg1	CD-CuMOF					678:685	CD-CuMOF	678:685	CD-CuMOF	678:685	For this purpose, a chiral host, β-Cyclodextrin based copper metal organic framework (CD-CuMOF) was synthesized and used for chelate complexation of ETB isomers (SS-ETB/RR-ETB).
32729518	4	75	theme	metal	653:657	arg1	framework					667:675	copper metal organic framework	646:675	copper metal organic framework (CD-CuMOF)	646:686	For this purpose, a chiral host, β-Cyclodextrin based copper metal organic framework (CD-CuMOF) was synthesized and used for chelate complexation of ETB isomers (SS-ETB/RR-ETB).
32729518	1	76	theme	Stereochemical	161:174	arg1	configuration					176:188	Stereochemical configuration	161:188	Stereochemical configuration of the drug	161:200	Stereochemical configuration of the drug is responsible for racemic switch with enantiomers in presence of chiral environment for human beings.
32729518	0	77	theme	copper	74:79	arg1	framework					95:103	chiral copper metal organic framework	67:103	chiral copper metal organic framework	67:103	Biomimetic sensor for ethambutol employing β-cyclodextrin mediated chiral copper metal organic framework and carbon nanofibers modified glassy carbon electrode.
32729518	8	78	theme	SS-ETB	1470:1475	arg1	isomers					1477:1483	SS-ETB isomers	1470:1483	SS-ETB isomers	1470:1483	It showed a linear response in the range of 1.0 x 10-7 to 1 x 10-4 M and 5.0 x 10-7 to 2.5 x 10-4 M with low detection limit of 3.10 x 10-8 M and 8.52 x 10-8 M for RR-ETB and SS-ETB isomers respectively.
32729518	9	79	theme	racemic	1559:1565	arg1	mixture					1567:1573	racemic mixture	1559:1573	racemic mixture	1559:1573	The sensor was applied for the estimation of ETB isomers in racemic mixture and real samples viz., blood, urine and pharmaceutical.
32729518	1	80	theme	chiral	268:273	arg1	environment					275:285	chiral environment	268:285	chiral environment for human beings	268:302	Stereochemical configuration of the drug is responsible for racemic switch with enantiomers in presence of chiral environment for human beings.
34545452	2	0	dep	Sierra	512:517	arg1	California					542:551	California	542:551	California	542:551	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	2	0	dep	Sierra	512:517	arg1	de					519:520	Sierra de San Francisco, Baja California	512:551	the Sierra de San Francisco, Baja California Peninsula	508:561	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	2	0	dep	Sierra	512:517	arg1	Baja					537:540	Baja	537:540	Baja	537:540	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	3	1	theme	milk	610:613	arg1	composition					624:634	milk chemical composition	610:634	milk chemical composition	610:634	Also, milk chemical composition was compared between flocks.
34545452	2	2	theme	general	320:326	arg1	pattern					345:351	a general flock production pattern	318:351	(a) a general flock production pattern throughout a year	314:369	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	9	3	theme	quality	1496:1502	arg1	milk					1504:1507	different quality milk	1486:1507	different quality milk	1486:1507	Goat flocks grazing across plant communities produced different quality milk.
34545452	6	4	theme	similar	1057:1063	arg1	values					1077:1082	similar persistency values	1057:1082	similar persistency values that were greater than those of the fat production curve	1057:1139	Milk, protein, lactose, and ash production curves had similar persistency values that were greater than those of the fat production curve.
34545452	10	5	theme	fat	1585:1587	arg1	content					1589:1595	great fat content	1579:1595	great fat content	1579:1595	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	6	6	theme	production	1124:1133	arg1	curve					1135:1139	the fat production curve	1116:1139	the fat production curve	1116:1139	Milk, protein, lactose, and ash production curves had similar persistency values that were greater than those of the fat production curve.
34545452	6	7	theme	ash	1031:1033	arg1	production					1035:1044	ash production	1031:1044	ash production	1031:1044	Milk, protein, lactose, and ash production curves had similar persistency values that were greater than those of the fat production curve.
34545452	4	8	with	pattern	710:716	arg1	waves					735:739	two greater waves	723:739	two greater waves in summer and spring	723:760	Annual flock milk production showed a wiggly pattern with two greater waves in summer and spring.
34545452	10	9	theme	protein	1610:1616	arg1	content					1618:1624	moderate protein content	1601:1624	moderate protein content	1601:1624	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	2	10	theme	plant	487:491	arg1	communities					493:503	arid plant communities	482:503	arid plant communities in the Sierra de San Francisco, Baja California Peninsula	482:561	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	7	11	theme	ash	1273:1275	arg1	production					1277:1286	ash production	1273:1286	ash production	1273:1286	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	1	12	theme	Lactation	89:97	arg1	tool					121:124	a valuable tool	110:124	a valuable tool for improving flock production efficiency, adjusting flock sizes, and improving farmers' income in grazing-based livestock production	110:258	Lactation curves are a valuable tool for improving flock production efficiency, adjusting flock sizes, and improving farmers' income in grazing-based livestock production.
34545452	1	12	theme	Lactation	89:97	arg1	curves					99:104	Lactation curves	89:104	Lactation curves	89:104	Lactation curves are a valuable tool for improving flock production efficiency, adjusting flock sizes, and improving farmers' income in grazing-based livestock production.
34545452	5	13	theme	average	963:969	arg1	production					977:986	the greatest average daily production	950:986	the greatest average daily production	950:986	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	2	14	theme	cubic	288:292	arg1	splines					294:300	natural cubic splines	280:300	natural cubic splines	280:300	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	1	15	theme	valuable	112:119	arg1	tool					121:124	a valuable tool	110:124	a valuable tool for improving flock production efficiency, adjusting flock sizes, and improving farmers' income in grazing-based livestock production	110:258	Lactation curves are a valuable tool for improving flock production efficiency, adjusting flock sizes, and improving farmers' income in grazing-based livestock production.
34545452	1	15	theme	valuable	112:119	arg1	curves					99:104	Lactation curves	89:104	Lactation curves	89:104	Lactation curves are a valuable tool for improving flock production efficiency, adjusting flock sizes, and improving farmers' income in grazing-based livestock production.
34545452	2	16	from	patterns	412:419	arg1	grazing					471:477	dual-purpose goats grazing	452:477	dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula	452:561	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	11	17	theme	milk	1721:1724	arg1	production					1726:1735	individual milk production	1710:1735	individual milk production	1710:1735	Also, breeding programs must pay attention that an increment in individual milk production could decrease fat and protein production, which are valuable for cheesemaking.
34545452	8	18	from	end	1427:1429	arg1	values					1413:1418	greater values	1405:1418	greater values at the end	1405:1429	Density (g/ml) and fat, protein, lactose, and ash contents (%) showed a ditch-shaped pattern across lactation, with greater values at the end.
34545452	10	19	theme	goat	1635:1638	arg1	milk					1640:1643	local goat milk	1629:1643	local goat milk	1629:1643	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	5	20	theme	individual	775:784	arg1	curve					796:800	The average individual lactation curve	763:800	The average individual lactation curve (kg/doe/day)	763:813	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	5	20	theme	individual	775:784	arg1	kg/doe/day					803:812	kg/doe/day	803:812	kg/doe/day	803:812	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	2	21	theme	Sierra	512:517	arg1	Peninsula					553:561	the Sierra de San Francisco, Baja California Peninsula	508:561	the Sierra de San Francisco, Baja California Peninsula	508:561	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	8	22	theme	protein	1313:1319	arg1	%					1349:1349	%	1349:1349	%	1349:1349	Density (g/ml) and fat, protein, lactose, and ash contents (%) showed a ditch-shaped pattern across lactation, with greater values at the end.
34545452	8	22	theme	protein	1313:1319	arg1	contents					1339:1346	fat, protein, lactose, and ash contents	1308:1346	fat, protein, lactose, and ash contents (%)	1308:1350	Density (g/ml) and fat, protein, lactose, and ash contents (%) showed a ditch-shaped pattern across lactation, with greater values at the end.
34545452	5	23	theme	fat	840:842	arg1	curve					796:800	The average individual lactation curve	763:800	The average individual lactation curve (kg/doe/day)	763:813	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	5	23	theme	fat	840:842	arg1	curves					830:835	production curves	819:835	production curves of fat, protein, lactose, and ashes (g/doe/day)	819:883	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	5	23	theme	fat	840:842	arg1	kg/doe/day					803:812	kg/doe/day	803:812	kg/doe/day	803:812	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	8	24	theme	lactose	1322:1328	arg1	%					1349:1349	%	1349:1349	%	1349:1349	Density (g/ml) and fat, protein, lactose, and ash contents (%) showed a ditch-shaped pattern across lactation, with greater values at the end.
34545452	8	24	theme	lactose	1322:1328	arg1	contents					1339:1346	fat, protein, lactose, and ash contents	1308:1346	fat, protein, lactose, and ash contents (%)	1308:1350	Density (g/ml) and fat, protein, lactose, and ash contents (%) showed a ditch-shaped pattern across lactation, with greater values at the end.
34545452	1	25	from	income	215:220	arg1	production					249:258	grazing-based livestock production	225:258	grazing-based livestock production	225:258	Lactation curves are a valuable tool for improving flock production efficiency, adjusting flock sizes, and improving farmers' income in grazing-based livestock production.
34545452	4	26	from	waves	735:739	arg1	summer					744:749	summer	744:749	summer	744:749	Annual flock milk production showed a wiggly pattern with two greater waves in summer and spring.
34545452	4	26	from	waves	735:739	arg1	spring					755:760	spring	755:760	spring	755:760	Annual flock milk production showed a wiggly pattern with two greater waves in summer and spring.
34545452	5	27	theme	protein	845:851	arg1	curve					796:800	The average individual lactation curve	763:800	The average individual lactation curve (kg/doe/day)	763:813	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	5	27	theme	protein	845:851	arg1	curves					830:835	production curves	819:835	production curves of fat, protein, lactose, and ashes (g/doe/day)	819:883	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	5	27	theme	protein	845:851	arg1	kg/doe/day					803:812	kg/doe/day	803:812	kg/doe/day	803:812	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	10	28	from	content	1589:1595	arg1	milk					1640:1643	local goat milk	1629:1643	local goat milk	1629:1643	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	2	29	theme	chemical	429:436	arg1	components					438:447	milk chemical components	424:447	milk chemical components	424:447	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	7	30	theme	high-positive	1219:1231	arg1	correlations					1233:1244	very high-positive correlations	1214:1244	very high-positive correlations with protein, lactose, and ash production	1214:1286	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	7	31	with	correlations	1233:1244	arg1	lactose					1260:1266	lactose	1260:1266	lactose	1260:1266	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	7	31	with	correlations	1233:1244	arg1	protein					1251:1257	protein	1251:1257	protein	1251:1257	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	7	31	with	correlations	1233:1244	arg1	production					1277:1286	ash production	1273:1286	ash production	1273:1286	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	7	31	with	correlations	1233:1244	arg1	production					1199:1208	fat production	1195:1208	fat production	1195:1208	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	1	32	theme	flock	140:144	arg1	efficiency					157:166	flock production efficiency	140:166	flock production efficiency	140:166	Lactation curves are a valuable tool for improving flock production efficiency, adjusting flock sizes, and improving farmers' income in grazing-based livestock production.
34545452	10	33	dep	content	1589:1595	arg1	a					1577:1577	a	1577:1577	a	1577:1577	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	0	34	theme	arid	72:75	arg1	rangelands					77:86	arid rangelands	72:86	arid rangelands	72:86	Milk production and quality patterns of double-purpose goats grazing in arid rangelands.
34545452	10	35	from	content	1618:1624	arg1	milk					1640:1643	local goat milk	1629:1643	local goat milk	1629:1643	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	2	36	theme	goats	465:469	arg1	grazing					471:477	dual-purpose goats grazing	452:477	dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula	452:561	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	2	37	from	curve	397:401	arg1	grazing					471:477	dual-purpose goats grazing	452:477	dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula	452:561	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	10	38	theme	valuable	1547:1554	arg1	resource					1556:1563	a valuable resource	1545:1563	a valuable resource that favors a great fat content and moderate protein content in local goat milk	1545:1643	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	10	38	theme	valuable	1547:1554	arg1	communities					1529:1539	native plant communities	1516:1539	native plant communities	1516:1539	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	2	39	dep	pattern	345:351	arg1	a					315:315	a	315:315	a	315:315	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	7	40	contain	had	1158:1160	arg1	production					1147:1156	Milk production	1142:1156	Milk production	1142:1156	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	7	40	contain	had	1158:1160	arg2	correlations					1233:1244	very high-positive correlations	1214:1244	very high-positive correlations with protein, lactose, and ash production	1214:1286	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	7	40	contain	had	1158:1160	arg2	correlation					1178:1188	a high-positive correlation	1162:1188	a high-positive correlation with fat production	1162:1208	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	8	41	theme	ditch-shaped	1361:1372	arg1	pattern					1374:1380	a ditch-shaped pattern	1359:1380	a ditch-shaped pattern across lactation	1359:1397	Density (g/ml) and fat, protein, lactose, and ash contents (%) showed a ditch-shaped pattern across lactation, with greater values at the end.
34545452	4	42	theme	flock	672:676	arg1	production					683:692	Annual flock milk production	665:692	Annual flock milk production	665:692	Annual flock milk production showed a wiggly pattern with two greater waves in summer and spring.
34545452	11	43	theme	individual	1710:1719	arg1	production					1726:1735	individual milk production	1710:1735	individual milk production	1710:1735	Also, breeding programs must pay attention that an increment in individual milk production could decrease fat and protein production, which are valuable for cheesemaking.
34545452	0	44	theme	Milk	0:3	arg1	production					5:14	Milk production	0:14	Milk production	0:14	Milk production and quality patterns of double-purpose goats grazing in arid rangelands.
34545452	2	45	dep	curve	397:401	arg1	b					373:373	b	373:373	b	373:373	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	5	46	theme	lactose	854:860	arg1	curve					796:800	The average individual lactation curve	763:800	The average individual lactation curve (kg/doe/day)	763:813	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	5	46	theme	lactose	854:860	arg1	curves					830:835	production curves	819:835	production curves of fat, protein, lactose, and ashes (g/doe/day)	819:883	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	5	46	theme	lactose	854:860	arg1	kg/doe/day					803:812	kg/doe/day	803:812	kg/doe/day	803:812	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	2	47	theme	lactation	387:395	arg1	curve					397:401	an average lactation curve	376:401	(b) an average lactation curve	372:401	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	2	48	theme	precipitation	589:601	arg1	years					571:575	years	571:575	years of abundant precipitation	571:601	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	10	49	theme	native	1516:1521	arg1	resource					1556:1563	a valuable resource	1545:1563	a valuable resource that favors a great fat content and moderate protein content in local goat milk	1545:1643	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	10	49	theme	native	1516:1521	arg1	communities					1529:1539	native plant communities	1516:1539	native plant communities	1516:1539	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	7	50	theme	high-positive	1164:1176	arg1	correlation					1178:1188	a high-positive correlation	1162:1188	a high-positive correlation with fat production	1162:1208	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	8	51	theme	greater	1405:1411	arg1	values					1413:1418	greater values	1405:1418	greater values at the end	1405:1429	Density (g/ml) and fat, protein, lactose, and ash contents (%) showed a ditch-shaped pattern across lactation, with greater values at the end.
34545452	0	52	theme	double-purpose	40:53	arg1	production					5:14	Milk production	0:14	Milk production	0:14	Milk production and quality patterns of double-purpose goats grazing in arid rangelands.
34545452	0	52	theme	double-purpose	40:53	arg1	patterns					28:35	quality patterns	20:35	quality patterns	20:35	Milk production and quality patterns of double-purpose goats grazing in arid rangelands.
34545452	5	53	theme	35-week	931:937	arg1	lactation					939:947	35-week lactation	931:947	35-week lactation	931:947	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	6	54	theme	protein	1009:1015	arg1	curves					1046:1051	Milk, protein, lactose, and ash production curves	1003:1051	Milk, protein, lactose, and ash production curves	1003:1051	Milk, protein, lactose, and ash production curves had similar persistency values that were greater than those of the fat production curve.
34545452	7	55	theme	Milk	1142:1145	arg1	production					1147:1156	Milk production	1142:1156	Milk production	1142:1156	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	2	56	from	grazing	471:477	arg1	communities					493:503	arid plant communities	482:503	arid plant communities in the Sierra de San Francisco, Baja California Peninsula	482:561	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	2	57	theme	flock	328:332	arg1	pattern					345:351	a general flock production pattern	318:351	(a) a general flock production pattern throughout a year	314:369	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	1	58	theme	livestock	239:247	arg1	production					249:258	grazing-based livestock production	225:258	grazing-based livestock production	225:258	Lactation curves are a valuable tool for improving flock production efficiency, adjusting flock sizes, and improving farmers' income in grazing-based livestock production.
34545452	9	59	theme	different	1486:1494	arg1	milk					1504:1507	different quality milk	1486:1507	different quality milk	1486:1507	Goat flocks grazing across plant communities produced different quality milk.
34545452	2	60	used	used	275:278	arg2	we					272:273	we	272:273	we	272:273	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	2	61	from	communities	493:503	arg1	Peninsula					553:561	the Sierra de San Francisco, Baja California Peninsula	508:561	the Sierra de San Francisco, Baja California Peninsula	508:561	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	3	62	theme	chemical	615:622	arg1	composition					624:634	milk chemical composition	610:634	milk chemical composition	610:634	Also, milk chemical composition was compared between flocks.
34545452	2	63	theme	natural	280:286	arg1	splines					294:300	natural cubic splines	280:300	natural cubic splines	280:300	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	5	64	theme	production	819:828	arg1	curves					830:835	production curves	819:835	production curves of fat, protein, lactose, and ashes (g/doe/day)	819:883	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	10	65	theme	great	1579:1583	arg1	content					1589:1595	great fat content	1579:1595	great fat content	1579:1595	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	5	66	theme	lactation	786:794	arg1	curve					796:800	The average individual lactation curve	763:800	The average individual lactation curve (kg/doe/day)	763:813	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	5	66	theme	lactation	786:794	arg1	kg/doe/day					803:812	kg/doe/day	803:812	kg/doe/day	803:812	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	6	67	theme	production	1035:1044	arg1	curves					1046:1051	Milk, protein, lactose, and ash production curves	1003:1051	Milk, protein, lactose, and ash production curves	1003:1051	Milk, protein, lactose, and ash production curves had similar persistency values that were greater than those of the fat production curve.
34545452	0	68	from	grazing	61:67	arg1	rangelands					77:86	arid rangelands	72:86	arid rangelands	72:86	Milk production and quality patterns of double-purpose goats grazing in arid rangelands.
34545452	6	69	theme	fat	1120:1122	arg1	curve					1135:1139	the fat production curve	1116:1139	the fat production curve	1116:1139	Milk, protein, lactose, and ash production curves had similar persistency values that were greater than those of the fat production curve.
34545452	1	70	theme	flock	179:183	arg1	sizes					185:189	flock sizes	179:189	flock sizes	179:189	Lactation curves are a valuable tool for improving flock production efficiency, adjusting flock sizes, and improving farmers' income in grazing-based livestock production.
34545452	2	71	from	pattern	345:351	arg1	grazing					471:477	dual-purpose goats grazing	452:477	dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula	452:561	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	9	72	theme	flocks	1437:1442	arg1	grazing					1444:1450	Goat flocks grazing	1432:1450	Goat flocks grazing across plant communities	1432:1475	Goat flocks grazing across plant communities produced different quality milk.
34545452	10	73	theme	moderate	1601:1608	arg1	content					1618:1624	moderate protein content	1601:1624	moderate protein content	1601:1624	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	2	74	theme	arid	482:485	arg1	communities					493:503	arid plant communities	482:503	arid plant communities in the Sierra de San Francisco, Baja California Peninsula	482:561	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	6	75	theme	lactose	1018:1024	arg1	curves					1046:1051	Milk, protein, lactose, and ash production curves	1003:1051	Milk, protein, lactose, and ash production curves	1003:1051	Milk, protein, lactose, and ash production curves had similar persistency values that were greater than those of the fat production curve.
34545452	7	76	with	correlation	1178:1188	arg1	lactose					1260:1266	lactose	1260:1266	lactose	1260:1266	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	7	76	with	correlation	1178:1188	arg1	protein					1251:1257	protein	1251:1257	protein	1251:1257	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	7	76	with	correlation	1178:1188	arg1	production					1277:1286	ash production	1273:1286	ash production	1273:1286	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	7	76	with	correlation	1178:1188	arg1	production					1199:1208	fat production	1195:1208	fat production	1195:1208	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	5	77	theme	daily	971:975	arg1	production					977:986	the greatest average daily production	950:986	the greatest average daily production	950:986	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	5	78	theme	average	767:773	arg1	curve					796:800	The average individual lactation curve	763:800	The average individual lactation curve (kg/doe/day)	763:813	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	5	78	theme	average	767:773	arg1	kg/doe/day					803:812	kg/doe/day	803:812	kg/doe/day	803:812	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	11	79	theme	breeding	1652:1659	arg1	programs					1661:1668	breeding programs	1652:1668	breeding programs	1652:1668	Also, breeding programs must pay attention that an increment in individual milk production could decrease fat and protein production, which are valuable for cheesemaking.
34545452	10	80	theme	local	1629:1633	arg1	milk					1640:1643	local goat milk	1629:1643	local goat milk	1629:1643	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	8	81	theme	ash	1335:1337	arg1	%					1349:1349	%	1349:1349	%	1349:1349	Density (g/ml) and fat, protein, lactose, and ash contents (%) showed a ditch-shaped pattern across lactation, with greater values at the end.
34545452	8	81	theme	ash	1335:1337	arg1	contents					1339:1346	fat, protein, lactose, and ash contents	1308:1346	fat, protein, lactose, and ash contents (%)	1308:1350	Density (g/ml) and fat, protein, lactose, and ash contents (%) showed a ditch-shaped pattern across lactation, with greater values at the end.
34545452	5	82	theme	greatest	954:961	arg1	production					977:986	the greatest average daily production	950:986	the greatest average daily production	950:986	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	2	83	theme	milk	424:427	arg1	components					438:447	milk chemical components	424:447	milk chemical components	424:447	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	6	84	theme	persistency	1065:1075	arg1	values					1077:1082	similar persistency values	1057:1082	similar persistency values that were greater than those of the fat production curve	1057:1139	Milk, protein, lactose, and ash production curves had similar persistency values that were greater than those of the fat production curve.
34545452	1	85	theme	production	146:155	arg1	efficiency					157:166	flock production efficiency	140:166	flock production efficiency	140:166	Lactation curves are a valuable tool for improving flock production efficiency, adjusting flock sizes, and improving farmers' income in grazing-based livestock production.
34545452	2	86	theme	abundant	580:587	arg1	precipitation					589:601	abundant precipitation	580:601	abundant precipitation	580:601	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	5	87	theme	ashes	867:871	arg1	curve					796:800	The average individual lactation curve	763:800	The average individual lactation curve (kg/doe/day)	763:813	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	5	87	theme	ashes	867:871	arg1	curves					830:835	production curves	819:835	production curves of fat, protein, lactose, and ashes (g/doe/day)	819:883	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	5	87	theme	ashes	867:871	arg1	kg/doe/day					803:812	kg/doe/day	803:812	kg/doe/day	803:812	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	2	88	theme	dual-purpose	452:463	arg1	grazing					471:477	dual-purpose goats grazing	452:477	dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula	452:561	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	11	89	from	increment	1697:1705	arg1	production					1726:1735	individual milk production	1710:1735	individual milk production	1710:1735	Also, breeding programs must pay attention that an increment in individual milk production could decrease fat and protein production, which are valuable for cheesemaking.
34545452	6	90	theme	Milk	1003:1006	arg1	curves					1046:1051	Milk, protein, lactose, and ash production curves	1003:1051	Milk, protein, lactose, and ash production curves	1003:1051	Milk, protein, lactose, and ash production curves had similar persistency values that were greater than those of the fat production curve.
34545452	2	91	theme	components	438:447	arg1	curve					397:401	an average lactation curve	376:401	(b) an average lactation curve	372:401	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	2	91	theme	components	438:447	arg1	patterns					412:419	(c) patterns	408:419	(c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula	408:561	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	2	91	theme	components	438:447	arg1	pattern					345:351	a general flock production pattern	318:351	(a) a general flock production pattern throughout a year	314:369	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	4	92	theme	wiggly	703:708	arg1	pattern					710:716	a wiggly pattern	701:716	a wiggly pattern with two greater waves in summer and spring	701:760	Annual flock milk production showed a wiggly pattern with two greater waves in summer and spring.
34545452	7	93	theme	fat	1195:1197	arg1	production					1199:1208	fat production	1195:1208	fat production	1195:1208	Milk production had a high-positive correlation with fat production and very high-positive correlations with protein, lactose, and ash production.
34545452	4	94	theme	Annual	665:670	arg1	production					683:692	Annual flock milk production	665:692	Annual flock milk production	665:692	Annual flock milk production showed a wiggly pattern with two greater waves in summer and spring.
34545452	8	95	theme	fat	1308:1310	arg1	%					1349:1349	%	1349:1349	%	1349:1349	Density (g/ml) and fat, protein, lactose, and ash contents (%) showed a ditch-shaped pattern across lactation, with greater values at the end.
34545452	8	95	theme	fat	1308:1310	arg1	contents					1339:1346	fat, protein, lactose, and ash contents	1308:1346	fat, protein, lactose, and ash contents (%)	1308:1350	Density (g/ml) and fat, protein, lactose, and ash contents (%) showed a ditch-shaped pattern across lactation, with greater values at the end.
34545452	0	96	theme	quality	20:26	arg1	patterns					28:35	quality patterns	20:35	quality patterns	20:35	Milk production and quality patterns of double-purpose goats grazing in arid rangelands.
34545452	9	97	theme	plant	1459:1463	arg1	communities					1465:1475	plant communities	1459:1475	plant communities	1459:1475	Goat flocks grazing across plant communities produced different quality milk.
34545452	2	98	theme	average	379:385	arg1	curve					397:401	an average lactation curve	376:401	(b) an average lactation curve	372:401	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	4	99	theme	milk	678:681	arg1	production					683:692	Annual flock milk production	665:692	Annual flock milk production	665:692	Annual flock milk production showed a wiggly pattern with two greater waves in summer and spring.
34545452	11	100	theme	protein	1760:1766	arg1	production					1768:1777	fat and protein production	1752:1777	fat and protein production	1752:1777	Also, breeding programs must pay attention that an increment in individual milk production could decrease fat and protein production, which are valuable for cheesemaking.
34545452	5	101	theme	wiggly	909:914	arg1	pattern					916:922	a decreasing and wiggly pattern	892:922	a decreasing and wiggly pattern across 35-week lactation	892:947	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	2	102	theme	c	409:409	arg1	patterns					412:419	(c) patterns	408:419	(c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula	408:561	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	11	103	theme	fat	1752:1754	arg1	production					1768:1777	fat and protein production	1752:1777	fat and protein production	1752:1777	Also, breeding programs must pay attention that an increment in individual milk production could decrease fat and protein production, which are valuable for cheesemaking.
34545452	9	104	theme	Goat	1432:1435	arg1	grazing					1444:1450	Goat flocks grazing	1432:1450	Goat flocks grazing across plant communities	1432:1475	Goat flocks grazing across plant communities produced different quality milk.
34545452	10	105	theme	plant	1523:1527	arg1	resource					1556:1563	a valuable resource	1545:1563	a valuable resource that favors a great fat content and moderate protein content in local goat milk	1545:1643	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	10	105	theme	plant	1523:1527	arg1	communities					1529:1539	native plant communities	1516:1539	native plant communities	1516:1539	Thus, native plant communities are a valuable resource that favors a great fat content and moderate protein content in local goat milk.
34545452	5	106	theme	decreasing	894:903	arg1	pattern					916:922	a decreasing and wiggly pattern	892:922	a decreasing and wiggly pattern across 35-week lactation	892:947	The average individual lactation curve (kg/doe/day) and production curves of fat, protein, lactose, and ashes (g/doe/day) showed a decreasing and wiggly pattern across 35-week lactation; the greatest average daily production was in week 2.
34545452	6	107	contain	had	1053:1055	arg1	curves					1046:1051	Milk, protein, lactose, and ash production curves	1003:1051	Milk, protein, lactose, and ash production curves	1003:1051	Milk, protein, lactose, and ash production curves had similar persistency values that were greater than those of the fat production curve.
34545452	6	107	contain	had	1053:1055	arg2	values					1077:1082	similar persistency values	1057:1082	similar persistency values that were greater than those of the fat production curve	1057:1139	Milk, protein, lactose, and ash production curves had similar persistency values that were greater than those of the fat production curve.
34545452	4	108	theme	greater	727:733	arg1	waves					735:739	two greater waves	723:739	two greater waves in summer and spring	723:760	Annual flock milk production showed a wiggly pattern with two greater waves in summer and spring.
34545452	2	109	theme	production	334:343	arg1	pattern					345:351	a general flock production pattern	318:351	(a) a general flock production pattern throughout a year	314:369	Therefore, we used natural cubic splines to estimate (a) a general flock production pattern throughout a year, (b) an average lactation curve, and (c) patterns of milk chemical components in dual-purpose goats grazing in arid plant communities in the Sierra de San Francisco, Baja California Peninsula, during years of abundant precipitation.
34545452	1	110	theme	grazing-based	225:237	arg1	production					249:258	grazing-based livestock production	225:258	grazing-based livestock production	225:258	Lactation curves are a valuable tool for improving flock production efficiency, adjusting flock sizes, and improving farmers' income in grazing-based livestock production.
34210599	14	0	theme	isolated	1913:1920	arg1	SVT					1922:1924	isolated SVT	1913:1924	isolated SVT	1913:1924	CONCLUSION At three month follow up, patients with isolated SVT are at risk of thromboembolic complications (mainly recurrent or extended SVT), despite anticoagulation.
34210599	2	1	theme	study	331:335	arg1	management					298:307	the management	294:307	the management of SVT (INSIGHTS-SVT) study	294:335	Therefore, the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study collected prospective data under real life conditions.
34210599	6	2	theme	±	757:757	arg1	years					764:768	mean age 60.2 ± 14.7 years	743:768	mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2	743:808	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	2	3	theme	Health	277:282	arg1	TrendS					284:289	the INvestigating SIGnificant Health TrendS	247:289	the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study	247:335	Therefore, the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study collected prospective data under real life conditions.
34210599	14	4	theme	complications	1956:1968	arg1	risk					1933:1936	risk	1933:1936	risk of thromboembolic complications (mainly recurrent or extended SVT)	1933:2003	CONCLUSION At three month follow up, patients with isolated SVT are at risk of thromboembolic complications (mainly recurrent or extended SVT), despite anticoagulation.
34210599	6	5	dep	included	733:740	arg1	years					764:768	mean age 60.2 ± 14.7 years	743:768	mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2	743:808	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	7	6	from	knee	855:858	arg1	%					867:867	26.7%	863:867	26.7%	863:867	SVT was below the knee in 54.5%, above the knee in 26.7%, above and below the knee in 18.8%.
34210599	7	6	from	knee	855:858	arg1	%					902:902	18.8%	898:902	18.8%	898:902	SVT was below the knee in 54.5%, above the knee in 26.7%, above and below the knee in 18.8%.
34210599	7	6	from	knee	855:858	arg1	%					842:842	54.5%	838:842	54.5%	838:842	SVT was below the knee in 54.5%, above the knee in 26.7%, above and below the knee in 18.8%.
34210599	6	7	theme	age	748:750	arg1	years					764:768	mean age 60.2 ± 14.7 years	743:768	mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2	743:808	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	2	8	theme	INvestigating	251:263	arg1	TrendS					284:289	the INvestigating SIGnificant Health TrendS	247:289	the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study	247:335	Therefore, the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study collected prospective data under real life conditions.
34210599	4	9	from	months	625:630	arg1	composite					503:511	a composite	501:511	a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension	501:593	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	9	from	months	625:630	arg1	recurrence					598:607	recurrence	598:607	recurrence of SVT at three months	598:630	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	9	from	months	625:630	arg1	SVT					612:614	SVT	612:614	SVT	612:614	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	9	from	months	625:630	arg1	outcome					489:495	The primary outcome	477:495	The primary outcome	477:495	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	9	from	months	625:630	arg1	extension					585:593	extension	585:593	extension	585:593	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	9	from	months	625:630	arg1	thrombosis					538:547	symptomatic deep vein thrombosis	516:547	symptomatic deep vein thrombosis (DVT)	516:553	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	9	from	months	625:630	arg1	embolism					566:573	pulmonary embolism	556:573	pulmonary embolism (PE)	556:578	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	1	10	theme	thrombosis	175:184	arg1	outcomes					146:153	outcomes	146:153	outcomes of superficial vein thrombosis (SVT)	146:190	OBJECTIVE Management and outcomes of superficial vein thrombosis (SVT) are highly variable and not well described.
34210599	1	10	theme	thrombosis	175:184	arg1	Management					131:140	OBJECTIVE Management	121:140	OBJECTIVE Management	121:140	OBJECTIVE Management and outcomes of superficial vein thrombosis (SVT) are highly variable and not well described.
34210599	8	11	theme	direct	1001:1006	arg1	[DOACs					1028:1033	direct oral anticoagulants [DOACs]	1001:1034	4.3% direct oral anticoagulants [DOACs]	996:1034	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	6	12	theme	±	798:798	arg1	kg/m2					804:808	mean BMI 29.4 ± 6.3 kg/m2	784:808	mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2	743:808	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	14	13	from	month	1882:1886	arg1	CONCLUSION					1862:1871	CONCLUSION	1862:1871	CONCLUSION At three month	1862:1886	CONCLUSION At three month follow up, patients with isolated SVT are at risk of thromboembolic complications (mainly recurrent or extended SVT), despite anticoagulation.
34210599	9	14	theme	extended	1205:1212	arg1	SVT					1214:1216	recurrent or extended SVT	1192:1216	recurrent or extended SVT	1192:1216	The primary outcome occurred in 5.8%; 4.7% had recurrent or extended SVT, 1.7% DVT, and 0.8% PE.
34210599	8	15	theme	anticoagulants	1013:1026	arg1	[DOACs					1028:1033	direct oral anticoagulants [DOACs]	1001:1034	4.3% direct oral anticoagulants [DOACs]	996:1034	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	8	16	theme	%	1060:1060	arg1	treatment					1074:1082	77.0% compression treatment	1056:1082	77.0% compression treatment	1056:1082	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	13	17	theme	SVT	1740:1742	arg1	event					1744:1748	the present SVT event	1728:1748	the present SVT event (HR 2.3)	1728:1757	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	13	17	theme	SVT	1740:1742	arg1	HR					1751:1752	HR 2.3	1751:1756	HR 2.3	1751:1756	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	15	18	theme	oral	2102:2105	arg1	anticoagulants					2107:2120	oral anticoagulants	2102:2120	oral anticoagulants	2102:2120	In this real life study, about one third had received either heparins, oral anticoagulants, or no anticoagulation.
34210599	9	19	theme	%	1222:1222	arg1	DVT					1224:1226	1.7% DVT	1219:1226	1.7% DVT	1219:1226	The primary outcome occurred in 5.8%; 4.7% had recurrent or extended SVT, 1.7% DVT, and 0.8% PE.
34210599	5	20	theme	safety	645:650	arg1	outcome					652:658	The primary safety outcome	633:658	The primary safety outcome	633:658	The primary safety outcome was clinically relevant bleeding.
34210599	5	20	theme	safety	645:650	arg1	bleeding					684:691	bleeding	684:691	bleeding	684:691	The primary safety outcome was clinically relevant bleeding.
34210599	13	21	theme	prior	1719:1723	arg1	SVT					1715:1717	another SVT	1707:1717	another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03)	1707:1859	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	12	22	theme	Primary	1398:1404	arg1	outcome					1406:1412	Primary outcome	1398:1412	Primary outcome adjusted by propensity score and for treatment duration	1398:1468	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	8	23	theme	%	1092:1092	arg1	surgery					1094:1100	1.9% surgery	1089:1100	1.9% surgery	1089:1100	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	9	24	theme	0.8	1233:1235	arg1	%					1236:1236	%	1236:1236	%	1236:1236	The primary outcome occurred in 5.8%; 4.7% had recurrent or extended SVT, 1.7% DVT, and 0.8% PE.
34210599	2	25	from	TrendS	284:289	arg1	management					298:307	the management	294:307	the management of SVT (INSIGHTS-SVT) study	294:335	Therefore, the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study collected prospective data under real life conditions.
34210599	0	26	theme	Vein	62:65	arg1	Thrombosis					67:76	Isolated Superficial Vein Thrombosis	41:76	Isolated Superficial Vein Thrombosis	41:76	Management and Outcomes of Patients with Isolated Superficial Vein Thrombosis under Real Life Conditions (INSIGHTS-SVT).
34210599	14	27	dep	mainly	1971:1976	arg1	extended					1991:1998	extended	1991:1998	extended	1991:1998	CONCLUSION At three month follow up, patients with isolated SVT are at risk of thromboembolic complications (mainly recurrent or extended SVT), despite anticoagulation.
34210599	14	27	dep	mainly	1971:1976	arg1	recurrent					1978:1986	recurrent	1978:1986	recurrent	1978:1986	CONCLUSION At three month follow up, patients with isolated SVT are at risk of thromboembolic complications (mainly recurrent or extended SVT), despite anticoagulation.
34210599	14	28	dep	complications	1956:1968	arg1	mainly					1971:1976	mainly	1971:1976	mainly	1971:1976	CONCLUSION At three month follow up, patients with isolated SVT are at risk of thromboembolic complications (mainly recurrent or extended SVT), despite anticoagulation.
34210599	1	29	theme	superficial	158:168	arg1	SVT					187:189	SVT	187:189	SVT	187:189	OBJECTIVE Management and outcomes of superficial vein thrombosis (SVT) are highly variable and not well described.
34210599	1	29	theme	superficial	158:168	arg1	thrombosis					175:184	superficial vein thrombosis	158:184	superficial vein thrombosis (SVT)	158:190	OBJECTIVE Management and outcomes of superficial vein thrombosis (SVT) are highly variable and not well described.
34210599	0	30	theme	Life	89:92	arg1	Conditions					94:103	Real Life Conditions	84:103	Real Life Conditions (INSIGHTS-SVT)	84:118	Management and Outcomes of Patients with Isolated Superficial Vein Thrombosis under Real Life Conditions (INSIGHTS-SVT).
34210599	0	30	theme	Life	89:92	arg1	INSIGHTS-SVT					106:117	INSIGHTS-SVT	106:117	INSIGHTS-SVT	106:117	Management and Outcomes of Patients with Isolated Superficial Vein Thrombosis under Real Life Conditions (INSIGHTS-SVT).
34210599	13	31	theme	associated	1659:1668	arg1	factors					1670:1676	associated factors	1659:1676	associated factors for primary outcome	1659:1696	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	15	32	theme	real	2039:2042	arg1	study					2049:2053	this real life study	2034:2053	this real life study	2034:2053	In this real life study, about one third had received either heparins, oral anticoagulants, or no anticoagulation.
34210599	13	33	theme	thrombus	1835:1842	arg1	HR					1852:1853	HR 1.03	1852:1858	HR 1.03	1852:1858	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	13	33	theme	thrombus	1835:1842	arg1	length					1844:1849	thrombus length	1835:1849	thrombus length (HR 1.03)	1835:1859	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	12	34	theme	hazard	1557:1562	arg1	ratio					1564:1568	hazard ratio [HR	1557:1572	hazard ratio [HR	1557:1572	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	2	35	theme	real	370:373	arg1	conditions					380:389	real life conditions	370:389	real life conditions	370:389	Therefore, the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study collected prospective data under real life conditions.
34210599	14	36	with	patients	1899:1906	arg1	SVT					1922:1924	isolated SVT	1913:1924	isolated SVT	1913:1924	CONCLUSION At three month follow up, patients with isolated SVT are at risk of thromboembolic complications (mainly recurrent or extended SVT), despite anticoagulation.
34210599	3	37	theme	SVT	472:474	arg1	study					426:430	Prospective observational study	400:430	METHODS Prospective observational study of objectively confirmed acute isolated SVT.	392:475	METHODS Prospective observational study of objectively confirmed acute isolated SVT.
34210599	13	38	theme	treatment	1801:1809	arg1	event					1744:1748	the present SVT event	1728:1748	the present SVT event (HR 2.3)	1728:1757	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	13	38	theme	treatment	1801:1809	arg1	duration					1784:1791	duration	1784:1791	duration of drug treatment per week (HR 0.92)	1784:1828	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	13	38	theme	treatment	1801:1809	arg1	HR					1751:1752	HR 2.3	1751:1756	HR 2.3	1751:1756	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	13	38	theme	treatment	1801:1809	arg1	length					1844:1849	thrombus length	1835:1849	thrombus length (HR 1.03)	1835:1859	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	13	38	theme	treatment	1801:1809	arg1	HR					1774:1775	HR 0.97	1774:1780	HR 0.97	1774:1780	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	13	38	theme	treatment	1801:1809	arg1	HR					1852:1853	HR 1.03	1852:1858	HR 1.03	1852:1858	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	13	38	theme	treatment	1801:1809	arg1	age					1760:1762	age	1760:1762	age per year (HR 0.97)	1760:1781	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	8	39	dep	%	1041:1041	arg1	analgesics					1043:1052	analgesics	1043:1052	14.5% analgesics	1037:1052	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	3	40	theme	Prospective	400:410	arg1	study					426:430	Prospective observational study	400:430	METHODS Prospective observational study of objectively confirmed acute isolated SVT.	392:475	METHODS Prospective observational study of objectively confirmed acute isolated SVT.
34210599	0	41	theme	Patients	27:34	arg1	Outcomes					15:22	Outcomes	15:22	Outcomes	15:22	Management and Outcomes of Patients with Isolated Superficial Vein Thrombosis under Real Life Conditions (INSIGHTS-SVT).
34210599	0	41	theme	Patients	27:34	arg1	Management					0:9	Management	0:9	Management	0:9	Management and Outcomes of Patients with Isolated Superficial Vein Thrombosis under Real Life Conditions (INSIGHTS-SVT).
34210599	6	42	theme	mean	784:787	arg1	kg/m2					804:808	mean BMI 29.4 ± 6.3 kg/m2	784:808	mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2	743:808	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	12	43	theme	low	1512:1514	arg1	heparin					1533:1539	low molecular weight heparin	1512:1539	low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017)	1512:1629	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	12	43	theme	low	1512:1514	arg1	%					1545:1545	4.4%	1542:1545	4.4%	1542:1545	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	12	43	theme	low	1512:1514	arg1	%					1554:1554	9.6%	1551:1554	9.6%	1551:1554	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	4	44	theme	deep	528:531	arg1	thrombosis					538:547	symptomatic deep vein thrombosis	516:547	symptomatic deep vein thrombosis (DVT)	516:553	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	44	theme	deep	528:531	arg1	DVT					550:552	DVT	550:552	DVT	550:552	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	6	45	theme	patients	719:726	arg1	total					704:708	A total	702:708	A total of 1 150 patients	702:726	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	0	46	theme	Isolated	41:48	arg1	Thrombosis					67:76	Isolated Superficial Vein Thrombosis	41:76	Isolated Superficial Vein Thrombosis	41:76	Management and Outcomes of Patients with Isolated Superficial Vein Thrombosis under Real Life Conditions (INSIGHTS-SVT).
34210599	8	47	theme	pharmacological	933:947	arg1	treatment					949:957	pharmacological treatment	933:957	pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics)	933:1053	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	3	48	dep	confirmed	447:455	arg1	isolated					463:470	isolated	463:470	isolated	463:470	METHODS Prospective observational study of objectively confirmed acute isolated SVT.
34210599	12	49	theme	weight	1526:1531	arg1	heparin					1533:1539	low molecular weight heparin	1512:1539	low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017)	1512:1629	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	12	49	theme	weight	1526:1531	arg1	%					1545:1545	4.4%	1542:1545	4.4%	1542:1545	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	12	49	theme	weight	1526:1531	arg1	%					1554:1554	9.6%	1551:1554	9.6%	1551:1554	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	4	50	theme	thrombosis	538:547	arg1	composite					503:511	a composite	501:511	a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension	501:593	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	50	theme	thrombosis	538:547	arg1	recurrence					598:607	recurrence	598:607	recurrence of SVT at three months	598:630	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	50	theme	thrombosis	538:547	arg1	SVT					612:614	SVT	612:614	SVT	612:614	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	50	theme	thrombosis	538:547	arg1	outcome					489:495	The primary outcome	477:495	The primary outcome	477:495	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	50	theme	thrombosis	538:547	arg1	extension					585:593	extension	585:593	extension	585:593	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	50	theme	thrombosis	538:547	arg1	thrombosis					538:547	symptomatic deep vein thrombosis	516:547	symptomatic deep vein thrombosis (DVT)	516:553	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	50	theme	thrombosis	538:547	arg1	embolism					566:573	pulmonary embolism	556:573	pulmonary embolism (PE)	556:578	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	6	51	theme	64.9	771:774	arg1	%					775:775	%	775:775	%	775:775	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	3	52	dep	isolated	463:470	arg1	acute					457:461	acute	457:461	acute	457:461	METHODS Prospective observational study of objectively confirmed acute isolated SVT.
34210599	7	53	from	knee	890:893	arg1	%					867:867	26.7%	863:867	26.7%	863:867	SVT was below the knee in 54.5%, above the knee in 26.7%, above and below the knee in 18.8%.
34210599	7	53	from	knee	890:893	arg1	%					842:842	54.5%	838:842	54.5%	838:842	SVT was below the knee in 54.5%, above the knee in 26.7%, above and below the knee in 18.8%.
34210599	7	53	from	knee	890:893	arg1	%					902:902	18.8%	898:902	18.8%	898:902	SVT was below the knee in 54.5%, above the knee in 26.7%, above and below the knee in 18.8%.
34210599	12	54	dep	%	1545:1545	arg1	.017					1625:1628	0.3 - 0.9; p = .017	1610:1628	.017	1625:1628	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	12	54	dep	%	1545:1545	arg1	interval					1596:1603	0.51; 95% confidence interval [CI	1575:1607	0.51; 95% confidence interval [CI	1575:1607	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	12	54	dep	%	1545:1545	arg1	ratio					1564:1568	hazard ratio [HR	1557:1572	hazard ratio [HR	1557:1572	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	11	55	theme	clinical	1335:1342	arg1	recovery					1344:1351	Complete clinical recovery	1326:1351	Complete clinical recovery of SVT	1326:1358	Complete clinical recovery of SVT was reported in 708 patients (62.4%).
34210599	9	56	theme	recurrent	1192:1200	arg1	SVT					1214:1216	recurrent or extended SVT	1192:1216	recurrent or extended SVT	1192:1216	The primary outcome occurred in 5.8%; 4.7% had recurrent or extended SVT, 1.7% DVT, and 0.8% PE.
34210599	4	57	theme	extension	585:593	arg1	composite					503:511	a composite	501:511	a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension	501:593	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	57	theme	extension	585:593	arg1	recurrence					598:607	recurrence	598:607	recurrence of SVT at three months	598:630	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	57	theme	extension	585:593	arg1	SVT					612:614	SVT	612:614	SVT	612:614	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	57	theme	extension	585:593	arg1	outcome					489:495	The primary outcome	477:495	The primary outcome	477:495	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	57	theme	extension	585:593	arg1	extension					585:593	extension	585:593	extension	585:593	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	57	theme	extension	585:593	arg1	thrombosis					538:547	symptomatic deep vein thrombosis	516:547	symptomatic deep vein thrombosis (DVT)	516:553	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	57	theme	extension	585:593	arg1	embolism					566:573	pulmonary embolism	556:573	pulmonary embolism (PE)	556:578	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	0	58	with	Patients	27:34	arg1	Thrombosis					67:76	Isolated Superficial Vein Thrombosis	41:76	Isolated Superficial Vein Thrombosis	41:76	Management and Outcomes of Patients with Isolated Superficial Vein Thrombosis under Real Life Conditions (INSIGHTS-SVT).
34210599	12	59	theme	treatment	1451:1459	arg1	duration					1461:1468	treatment duration	1451:1468	treatment duration	1451:1468	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	4	60	theme	embolism	566:573	arg1	composite					503:511	a composite	501:511	a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension	501:593	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	60	theme	embolism	566:573	arg1	recurrence					598:607	recurrence	598:607	recurrence of SVT at three months	598:630	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	60	theme	embolism	566:573	arg1	SVT					612:614	SVT	612:614	SVT	612:614	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	60	theme	embolism	566:573	arg1	outcome					489:495	The primary outcome	477:495	The primary outcome	477:495	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	60	theme	embolism	566:573	arg1	extension					585:593	extension	585:593	extension	585:593	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	60	theme	embolism	566:573	arg1	thrombosis					538:547	symptomatic deep vein thrombosis	516:547	symptomatic deep vein thrombosis (DVT)	516:553	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	60	theme	embolism	566:573	arg1	embolism					566:573	pulmonary embolism	556:573	pulmonary embolism (PE)	556:578	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	13	61	theme	multivariable	1635:1647	arg1	analysis					1649:1656	multivariable analysis	1635:1656	multivariable analysis	1635:1656	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	2	62	theme	SIGnificant	265:275	arg1	TrendS					284:289	the INvestigating SIGnificant Health TrendS	247:289	the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study	247:335	Therefore, the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study collected prospective data under real life conditions.
34210599	1	63	theme	vein	170:173	arg1	SVT					187:189	SVT	187:189	SVT	187:189	OBJECTIVE Management and outcomes of superficial vein thrombosis (SVT) are highly variable and not well described.
34210599	1	63	theme	vein	170:173	arg1	thrombosis					175:184	superficial vein thrombosis	158:184	superficial vein thrombosis (SVT)	158:190	OBJECTIVE Management and outcomes of superficial vein thrombosis (SVT) are highly variable and not well described.
34210599	6	64	theme	6.3	800:802	arg1	kg/m2					804:808	mean BMI 29.4 ± 6.3 kg/m2	784:808	mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2	743:808	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	12	65	theme	propensity	1426:1435	arg1	score					1437:1441	propensity score	1426:1441	propensity score	1426:1441	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	6	66	theme	mean	743:746	arg1	years					764:768	mean age 60.2 ± 14.7 years	743:768	mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2	743:808	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	12	67	theme	0.3	1610:1612	arg1	.017					1625:1628	0.3 - 0.9; p = .017	1610:1628	.017	1625:1628	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	8	68	dep	treatment	949:957	arg1	%					964:964	65.7%	960:964	65.7% fondaparinux	960:977	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	8	68	dep	treatment	949:957	arg1	%					1041:1041	14.5%	1037:1041	14.5% analgesics	1037:1052	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	8	68	dep	treatment	949:957	arg1	%					999:999	4.3%	996:999	4.3% direct oral anticoagulants [DOACs]	996:1034	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	8	68	dep	treatment	949:957	arg1	%					984:984	23.2%	980:984	23.2% heparins	980:993	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	8	69	theme	oral	1008:1011	arg1	[DOACs					1028:1033	direct oral anticoagulants [DOACs]	1001:1034	4.3% direct oral anticoagulants [DOACs]	996:1034	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	6	70	dep	years	764:768	arg1	kg/m2					804:808	mean BMI 29.4 ± 6.3 kg/m2	784:808	mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2	743:808	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	6	70	dep	years	764:768	arg1	women					777:781	64.9% women	771:781	mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2	743:808	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	8	71	theme	77.0	1056:1059	arg1	%					1060:1060	%	1060:1060	%	1060:1060	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	9	72	theme	1.7	1219:1221	arg1	%					1222:1222	%	1222:1222	%	1222:1222	The primary outcome occurred in 5.8%; 4.7% had recurrent or extended SVT, 1.7% DVT, and 0.8% PE.
34210599	12	73	theme	confidence	1585:1594	arg1	interval					1596:1603	0.51; 95% confidence interval [CI	1575:1607	0.51; 95% confidence interval [CI	1575:1607	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	4	74	theme	SVT	612:614	arg1	composite					503:511	a composite	501:511	a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension	501:593	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	74	theme	SVT	612:614	arg1	recurrence					598:607	recurrence	598:607	recurrence of SVT at three months	598:630	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	74	theme	SVT	612:614	arg1	SVT					612:614	SVT	612:614	SVT	612:614	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	74	theme	SVT	612:614	arg1	outcome					489:495	The primary outcome	477:495	The primary outcome	477:495	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	74	theme	SVT	612:614	arg1	extension					585:593	extension	585:593	extension	585:593	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	74	theme	SVT	612:614	arg1	thrombosis					538:547	symptomatic deep vein thrombosis	516:547	symptomatic deep vein thrombosis (DVT)	516:553	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	74	theme	SVT	612:614	arg1	embolism					566:573	pulmonary embolism	556:573	pulmonary embolism (PE)	556:578	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	5	75	theme	primary	637:643	arg1	outcome					652:658	The primary safety outcome	633:658	The primary safety outcome	633:658	The primary safety outcome was clinically relevant bleeding.
34210599	5	75	theme	primary	637:643	arg1	bleeding					684:691	bleeding	684:691	bleeding	684:691	The primary safety outcome was clinically relevant bleeding.
34210599	7	76	from	knee	830:833	arg1	%					867:867	26.7%	863:867	26.7%	863:867	SVT was below the knee in 54.5%, above the knee in 26.7%, above and below the knee in 18.8%.
34210599	7	76	from	knee	830:833	arg1	%					902:902	18.8%	898:902	18.8%	898:902	SVT was below the knee in 54.5%, above the knee in 26.7%, above and below the knee in 18.8%.
34210599	7	76	from	knee	830:833	arg1	%					842:842	54.5%	838:842	54.5%	838:842	SVT was below the knee in 54.5%, above the knee in 26.7%, above and below the knee in 18.8%.
34210599	1	77	theme	OBJECTIVE	121:129	arg1	Management					131:140	OBJECTIVE Management	121:140	OBJECTIVE Management	121:140	OBJECTIVE Management and outcomes of superficial vein thrombosis (SVT) are highly variable and not well described.
34210599	8	78	theme	1.9	1089:1091	arg1	%					1092:1092	%	1092:1092	%	1092:1092	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	13	79	theme	present	1732:1738	arg1	event					1744:1748	the present SVT event	1728:1748	the present SVT event (HR 2.3)	1728:1757	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	13	79	theme	present	1732:1738	arg1	HR					1751:1752	HR 2.3	1751:1756	HR 2.3	1751:1756	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	9	80	theme	%	1236:1236	arg1	PE					1238:1239	0.8% PE	1233:1239	0.8% PE	1233:1239	The primary outcome occurred in 5.8%; 4.7% had recurrent or extended SVT, 1.7% DVT, and 0.8% PE.
34210599	15	81	theme	no	2126:2127	arg1	anticoagulation					2129:2143	no anticoagulation	2126:2143	no anticoagulation	2126:2143	In this real life study, about one third had received either heparins, oral anticoagulants, or no anticoagulation.
34210599	14	82	dep	recurrent	1978:1986	arg1	SVT					2000:2002	SVT	2000:2002	SVT	2000:2002	CONCLUSION At three month follow up, patients with isolated SVT are at risk of thromboembolic complications (mainly recurrent or extended SVT), despite anticoagulation.
34210599	12	83	theme	0.9	1616:1618	arg1	.017					1625:1628	0.3 - 0.9; p = .017	1610:1628	.017	1625:1628	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	0	84	theme	Real	84:87	arg1	Conditions					94:103	Real Life Conditions	84:103	Real Life Conditions (INSIGHTS-SVT)	84:118	Management and Outcomes of Patients with Isolated Superficial Vein Thrombosis under Real Life Conditions (INSIGHTS-SVT).
34210599	0	84	theme	Real	84:87	arg1	INSIGHTS-SVT					106:117	INSIGHTS-SVT	106:117	INSIGHTS-SVT	106:117	Management and Outcomes of Patients with Isolated Superficial Vein Thrombosis under Real Life Conditions (INSIGHTS-SVT).
34210599	4	85	theme	symptomatic	516:526	arg1	thrombosis					538:547	symptomatic deep vein thrombosis	516:547	symptomatic deep vein thrombosis (DVT)	516:553	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	85	theme	symptomatic	516:526	arg1	DVT					550:552	DVT	550:552	DVT	550:552	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	9	86	contain	had	1188:1190	arg2	DVT					1224:1226	1.7% DVT	1219:1226	1.7% DVT	1219:1226	The primary outcome occurred in 5.8%; 4.7% had recurrent or extended SVT, 1.7% DVT, and 0.8% PE.
34210599	9	86	contain	had	1188:1190	arg2	PE					1238:1239	0.8% PE	1233:1239	0.8% PE	1233:1239	The primary outcome occurred in 5.8%; 4.7% had recurrent or extended SVT, 1.7% DVT, and 0.8% PE.
34210599	9	86	contain	had	1188:1190	arg2	SVT					1214:1216	recurrent or extended SVT	1192:1216	recurrent or extended SVT	1192:1216	The primary outcome occurred in 5.8%; 4.7% had recurrent or extended SVT, 1.7% DVT, and 0.8% PE.
34210599	9	86	contain	had	1188:1190	arg1	%					1186:1186	4.7%	1183:1186	4.7%	1183:1186	The primary outcome occurred in 5.8%; 4.7% had recurrent or extended SVT, 1.7% DVT, and 0.8% PE.
34210599	12	87	theme	%	1583:1583	arg1	interval					1596:1603	0.51; 95% confidence interval [CI	1575:1607	0.51; 95% confidence interval [CI	1575:1607	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	4	88	theme	primary	481:487	arg1	composite					503:511	a composite	501:511	a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension	501:593	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	88	theme	primary	481:487	arg1	SVT					612:614	SVT	612:614	SVT	612:614	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	88	theme	primary	481:487	arg1	outcome					489:495	The primary outcome	477:495	The primary outcome	477:495	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	88	theme	primary	481:487	arg1	extension					585:593	extension	585:593	extension	585:593	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	88	theme	primary	481:487	arg1	thrombosis					538:547	symptomatic deep vein thrombosis	516:547	symptomatic deep vein thrombosis (DVT)	516:553	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	88	theme	primary	481:487	arg1	embolism					566:573	pulmonary embolism	556:573	pulmonary embolism (PE)	556:578	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	8	89	dep	%	984:984	arg1	heparins					986:993	heparins	986:993	23.2% heparins	980:993	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	15	90	theme	life	2044:2047	arg1	study					2049:2053	this real life study	2034:2053	this real life study	2034:2053	In this real life study, about one third had received either heparins, oral anticoagulants, or no anticoagulation.
34210599	3	91	dep	METHODS	392:398	arg1	study					426:430	Prospective observational study	400:430	METHODS Prospective observational study of objectively confirmed acute isolated SVT.	392:475	METHODS Prospective observational study of objectively confirmed acute isolated SVT.
34210599	3	92	theme	confirmed	447:455	arg1	SVT					472:474	objectively confirmed acute isolated SVT	435:474	objectively confirmed acute isolated SVT	435:474	METHODS Prospective observational study of objectively confirmed acute isolated SVT.
34210599	13	93	theme	primary	1682:1688	arg1	outcome					1690:1696	primary outcome	1682:1696	primary outcome	1682:1696	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	8	94	dep	%	964:964	arg1	fondaparinux					966:977	fondaparinux	966:977	65.7% fondaparinux	960:977	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	13	95	theme	drug	1796:1799	arg1	treatment					1801:1809	drug treatment	1796:1809	drug treatment	1796:1809	On multivariable analysis, associated factors for primary outcome included another SVT prior to the present SVT event (HR 2.3), age per year (HR 0.97), duration of drug treatment per week (HR 0.92), and thrombus length (HR 1.03).
34210599	4	96	theme	pulmonary	556:564	arg1	PE					576:577	PE	576:577	PE	576:577	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	96	theme	pulmonary	556:564	arg1	embolism					566:573	pulmonary embolism	556:573	pulmonary embolism (PE)	556:578	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	6	97	theme	BMI	789:791	arg1	kg/m2					804:808	mean BMI 29.4 ± 6.3 kg/m2	784:808	mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2	743:808	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	3	98	theme	observational	412:424	arg1	study					426:430	Prospective observational study	400:430	METHODS Prospective observational study of objectively confirmed acute isolated SVT.	392:475	METHODS Prospective observational study of objectively confirmed acute isolated SVT.
34210599	4	99	theme	vein	533:536	arg1	thrombosis					538:547	symptomatic deep vein thrombosis	516:547	symptomatic deep vein thrombosis (DVT)	516:553	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	4	99	theme	vein	533:536	arg1	DVT					550:552	DVT	550:552	DVT	550:552	The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months.
34210599	0	100	theme	Superficial	50:60	arg1	Thrombosis					67:76	Isolated Superficial Vein Thrombosis	41:76	Isolated Superficial Vein Thrombosis	41:76	Management and Outcomes of Patients with Isolated Superficial Vein Thrombosis under Real Life Conditions (INSIGHTS-SVT).
34210599	14	101	theme	thromboembolic	1941:1954	arg1	complications					1956:1968	thromboembolic complications	1941:1968	thromboembolic complications (mainly recurrent or extended SVT)	1941:2003	CONCLUSION At three month follow up, patients with isolated SVT are at risk of thromboembolic complications (mainly recurrent or extended SVT), despite anticoagulation.
34210599	2	102	theme	INSIGHTS-SVT	317:328	arg1	study					331:335	SVT (INSIGHTS-SVT) study	312:335	SVT (INSIGHTS-SVT) study	312:335	Therefore, the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study collected prospective data under real life conditions.
34210599	9	103	theme	primary	1149:1155	arg1	outcome					1157:1163	The primary outcome	1145:1163	The primary outcome	1145:1163	The primary outcome occurred in 5.8%; 4.7% had recurrent or extended SVT, 1.7% DVT, and 0.8% PE.
34210599	6	104	theme	%	775:775	arg1	women					777:781	64.9% women	771:781	mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2	743:808	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	12	105	theme	molecular	1516:1524	arg1	heparin					1533:1539	low molecular weight heparin	1512:1539	low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017)	1512:1629	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	12	105	theme	molecular	1516:1524	arg1	%					1545:1545	4.4%	1542:1545	4.4%	1542:1545	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	12	105	theme	molecular	1516:1524	arg1	%					1554:1554	9.6%	1551:1554	9.6%	1551:1554	Primary outcome adjusted by propensity score and for treatment duration was lower with fondaparinux compared with low molecular weight heparin (4.4% vs. 9.6%; hazard ratio [HR] 0.51; 95% confidence interval [CI] 0.3 - 0.9; p = .017).
34210599	6	106	dep	RESULTS	694:700	arg1	included					733:740	included	733:740	were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2)	728:809	RESULTS A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2).
34210599	8	107	theme	compression	1062:1072	arg1	treatment					1074:1082	77.0% compression treatment	1056:1082	77.0% compression treatment	1056:1082	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	8	108	dep	%	999:999	arg1	[DOACs					1028:1033	direct oral anticoagulants [DOACs]	1001:1034	4.3% direct oral anticoagulants [DOACs]	996:1034	At baseline, 93.6% received pharmacological treatment (65.7% fondaparinux, 23.2% heparins, 4.3% direct oral anticoagulants [DOACs], 14.5% analgesics), 77.0% compression treatment, and 1.9% surgery; 6.4% did not receive any anticoagulation.
34210599	11	109	theme	Complete	1326:1333	arg1	recovery					1344:1351	Complete clinical recovery	1326:1351	Complete clinical recovery of SVT	1326:1358	Complete clinical recovery of SVT was reported in 708 patients (62.4%).
34210599	2	110	theme	SVT	312:314	arg1	study					331:335	SVT (INSIGHTS-SVT) study	312:335	SVT (INSIGHTS-SVT) study	312:335	Therefore, the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study collected prospective data under real life conditions.
34210599	10	111	from	%	1296:1296	arg1	%					1323:1323	0.3%	1320:1323	0.3%	1320:1323	Clinically relevant non-major bleeding occurred in 1.2% and major bleeding in 0.3%.
34210599	2	112	theme	life	375:378	arg1	conditions					380:389	real life conditions	370:389	real life conditions	370:389	Therefore, the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study collected prospective data under real life conditions.
34210599	11	113	theme	SVT	1356:1358	arg1	recovery					1344:1351	Complete clinical recovery	1326:1351	Complete clinical recovery of SVT	1326:1358	Complete clinical recovery of SVT was reported in 708 patients (62.4%).
34210599	2	114	theme	prospective	347:357	arg1	data					359:362	prospective data	347:362	prospective data	347:362	Therefore, the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study collected prospective data under real life conditions.
33662416	0	0	theme	cellulose-based	97:111	arg1	hydrogels					113:121	carboxymethyl cellulose-based hydrogels	83:121	carboxymethyl cellulose-based hydrogels	83:121	Physicochemical characterization, drug release, and biocompatibility evaluation of carboxymethyl cellulose-based hydrogels reinforced with sepiolite nanoclay.
33662416	2	1	theme	-loaded	455:461	arg1	composites					463:472	-loaded composites	455:472	its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU)	432:485	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	2	2	dep	5-fluorouracil	436:449	arg1	composites					463:472	-loaded composites	455:472	its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU)	432:485	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	3	3	dep	PCNCHF5	709:715	arg1	to					706:707	to	706:707	to	706:707	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	7	4	theme	live/dead	1120:1128	arg1	assay					1130:1134	The live/dead assay	1116:1134	The live/dead assay	1116:1134	The live/dead assay show the proliferation of fibroblast cells, confirming the biocompatibility of the hydrogels.
33662416	0	5	theme	carboxymethyl	83:95	arg1	hydrogels					113:121	carboxymethyl cellulose-based hydrogels	83:121	carboxymethyl cellulose-based hydrogels	83:121	Physicochemical characterization, drug release, and biocompatibility evaluation of carboxymethyl cellulose-based hydrogels reinforced with sepiolite nanoclay.
33662416	2	6	theme	XRD	541:543	arg1	analyses					572:579	FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses	535:579	FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses	535:579	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	2	7	theme	TGA	568:570	arg1	analyses					572:579	FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses	535:579	FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses	535:579	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	5	8	theme	human	1002:1006	arg1	cells					1031:1035	human skin fibroblast (CCDK) cells	1002:1035	human skin fibroblast (CCDK) cells	1002:1035	The biocompatibility of PCNCHFs was tested against human skin fibroblast (CCDK) cells.
33662416	3	9	theme	pristine	761:768	arg1	PCNCHF0					788:794	PCNCHF0	788:794	PCNCHF0	788:794	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	3	9	theme	pristine	761:768	arg1	hydrogel					778:785	the pristine polymer hydrogel	757:785	the pristine polymer hydrogel (PCNCHF0)	757:795	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	8	10	theme	biological	1415:1424	arg1	applications					1426:1437	other biological applications	1409:1437	other biological applications	1409:1437	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	8	11	theme	pH-sensitive	1234:1245	arg1	release					1258:1264	The pH-sensitive PCNCHFs@FU release	1230:1264	The pH-sensitive PCNCHFs@FU release	1230:1264	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	8	11	theme	pH-sensitive	1234:1245	arg1	suitable					1275:1282	suitable	1275:1282	suitable	1275:1282	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	0	12	theme	hydrogels	113:121	arg1	evaluation					69:78	biocompatibility evaluation	52:78	biocompatibility evaluation	52:78	Physicochemical characterization, drug release, and biocompatibility evaluation of carboxymethyl cellulose-based hydrogels reinforced with sepiolite nanoclay.
33662416	0	12	theme	hydrogels	113:121	arg1	characterization					16:31	Physicochemical characterization	0:31	Physicochemical characterization	0:31	Physicochemical characterization, drug release, and biocompatibility evaluation of carboxymethyl cellulose-based hydrogels reinforced with sepiolite nanoclay.
33662416	0	12	theme	hydrogels	113:121	arg1	release					39:45	drug release	34:45	drug release	34:45	Physicochemical characterization, drug release, and biocompatibility evaluation of carboxymethyl cellulose-based hydrogels reinforced with sepiolite nanoclay.
33662416	5	13	theme	skin	1008:1011	arg1	cells					1031:1035	human skin fibroblast (CCDK) cells	1002:1035	human skin fibroblast (CCDK) cells	1002:1035	The biocompatibility of PCNCHFs was tested against human skin fibroblast (CCDK) cells.
33662416	2	14	theme	FTIR	535:538	arg1	analyses					572:579	FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses	535:579	FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses	535:579	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	8	15	from	release	1293:1299	arg1	therapy					1311:1317	cancer therapy	1304:1317	cancer therapy	1304:1317	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	0	16	theme	sepiolite	139:147	arg1	nanoclay					149:156	sepiolite nanoclay	139:156	sepiolite nanoclay	139:156	Physicochemical characterization, drug release, and biocompatibility evaluation of carboxymethyl cellulose-based hydrogels reinforced with sepiolite nanoclay.
33662416	5	17	theme	fibroblast	1013:1022	arg1	cells					1031:1035	human skin fibroblast (CCDK) cells	1002:1035	human skin fibroblast (CCDK) cells	1002:1035	The biocompatibility of PCNCHFs was tested against human skin fibroblast (CCDK) cells.
33662416	2	18	theme	DSC	559:561	arg1	analyses					572:579	FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses	535:579	FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses	535:579	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	8	19	theme	@	1254:1254	arg1	release					1258:1264	The pH-sensitive PCNCHFs@FU release	1230:1264	The pH-sensitive PCNCHFs@FU release	1230:1264	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	8	19	theme	@	1254:1254	arg1	suitable					1275:1282	suitable	1275:1282	suitable	1275:1282	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	7	20	theme	hydrogels	1219:1227	arg1	biocompatibility					1195:1210	the biocompatibility	1191:1210	the biocompatibility of the hydrogels	1191:1227	The live/dead assay show the proliferation of fibroblast cells, confirming the biocompatibility of the hydrogels.
33662416	2	21	theme	PCNCHFs	475:481	arg1	5-fluorouracil					436:449	its 5-fluorouracil	432:449	its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU)	432:485	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	2	21	theme	PCNCHFs	475:481	arg1	FU					483:484	PCNCHFs@FU	475:484	PCNCHFs@FU	475:484	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	2	22	theme	EDX	554:556	arg1	analyses					572:579	FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses	535:579	FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses	535:579	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	8	23	theme	PCNCHFs	1247:1253	arg1	release					1258:1264	The pH-sensitive PCNCHFs@FU release	1230:1264	The pH-sensitive PCNCHFs@FU release	1230:1264	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	8	23	theme	PCNCHFs	1247:1253	arg1	suitable					1275:1282	suitable	1275:1282	suitable	1275:1282	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	2	24	theme	@	482:482	arg1	5-fluorouracil					436:449	its 5-fluorouracil	432:449	its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU)	432:485	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	2	24	theme	@	482:482	arg1	FU					483:484	PCNCHFs@FU	475:484	PCNCHFs@FU	475:484	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	3	25	theme	nanosepiolite-loaded	657:676	arg1	composites					686:695	The nanosepiolite-loaded polymer composites	653:695	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5)	653:716	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	3	25	theme	nanosepiolite-loaded	657:676	arg1	PCNCHF5					709:715	PCNCHF1 to PCNCHF5	698:715	PCNCHF1 to PCNCHF5	698:715	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	3	26	theme	polymer	678:684	arg1	composites					686:695	The nanosepiolite-loaded polymer composites	653:695	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5)	653:716	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	3	26	theme	polymer	678:684	arg1	PCNCHF5					709:715	PCNCHF1 to PCNCHF5	698:715	PCNCHF1 to PCNCHF5	698:715	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	3	27	theme	thermal	816:822	arg1	properties					824:833	the thermal properties	812:833	the thermal properties (glass- and melting-transition)	812:865	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	0	28	theme	Physicochemical	0:14	arg1	characterization					16:31	Physicochemical characterization	0:31	Physicochemical characterization	0:31	Physicochemical characterization, drug release, and biocompatibility evaluation of carboxymethyl cellulose-based hydrogels reinforced with sepiolite nanoclay.
33662416	1	29	dep	reinforcement	336:348	arg1	%					334:334	%	334:334	%	334:334	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	2	30	theme	FE-SEM	546:551	arg1	analyses					572:579	FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses	535:579	FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses	535:579	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	6	31	theme	cells	1055:1059	arg1	viability					1042:1050	The viability	1038:1050	The viability of cells exposed to all PCNCHFs	1038:1082	The viability of cells exposed to all PCNCHFs was >95% after 72 h of culture.
33662416	6	31	theme	cells	1055:1059	arg1	%					1091:1091	>95%	1088:1091	>95%	1088:1091	The viability of cells exposed to all PCNCHFs was >95% after 72 h of culture.
33662416	0	32	theme	drug	34:37	arg1	release					39:45	drug release	34:45	drug release	34:45	Physicochemical characterization, drug release, and biocompatibility evaluation of carboxymethyl cellulose-based hydrogels reinforced with sepiolite nanoclay.
33662416	8	33	theme	other	1409:1413	arg1	applications					1426:1437	other biological applications	1409:1437	other biological applications	1409:1437	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	2	34	theme	FU	503:504	arg1	release					506:512	FU release	503:512	FU release	503:512	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	1	35	theme	caboxymethyl	230:241	arg1	cellulose					243:251	caboxymethyl cellulose	230:251	caboxymethyl cellulose	230:251	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	8	36	theme	FU	1255:1256	arg1	release					1258:1264	The pH-sensitive PCNCHFs@FU release	1230:1264	The pH-sensitive PCNCHFs@FU release	1230:1264	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	8	36	theme	FU	1255:1256	arg1	suitable					1275:1282	suitable	1275:1282	suitable	1275:1282	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	8	37	theme	food	1389:1392	arg1	packaging					1394:1402	food packaging	1389:1402	food packaging	1389:1402	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	4	38	theme	FU	920:921	arg1	release					923:929	prolonged FU release	910:929	prolonged FU release	910:929	The PCNCHFs@FU demonstrated prolonged FU release at pH 7.4 for 32 h.
33662416	1	39	dep	%	334:334	arg1	1.5					331:333	1.5	331:333	1.5	331:333	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	1	39	dep	%	334:334	arg1	0.9					323:325	0.9	323:325	0.9	323:325	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	1	40	theme	simple	378:383	arg1	route					409:413	a simple, rapid, and inexpensive route	376:413	a simple, rapid, and inexpensive route	376:413	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	4	41	theme	prolonged	910:918	arg1	release					923:929	prolonged FU release	910:929	prolonged FU release	910:929	The PCNCHFs@FU demonstrated prolonged FU release at pH 7.4 for 32 h.
33662416	0	42	theme	biocompatibility	52:67	arg1	evaluation					69:78	biocompatibility evaluation	52:78	biocompatibility evaluation	52:78	Physicochemical characterization, drug release, and biocompatibility evaluation of carboxymethyl cellulose-based hydrogels reinforced with sepiolite nanoclay.
33662416	1	43	theme	rapid	386:390	arg1	route					409:413	a simple, rapid, and inexpensive route	376:413	a simple, rapid, and inexpensive route	376:413	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	6	44	theme	culture	1107:1113	arg1	72 h					1099:1102	72 h	1099:1102	72 h of culture	1099:1113	The viability of cells exposed to all PCNCHFs was >95% after 72 h of culture.
33662416	2	45	theme	morphological	614:626	arg1	properties					641:650	their structural, morphological, and thermal properties	596:650	their structural, morphological, and thermal properties	596:650	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	7	46	theme	fibroblast	1162:1171	arg1	cells					1173:1177	fibroblast cells	1162:1177	fibroblast cells	1162:1177	The live/dead assay show the proliferation of fibroblast cells, confirming the biocompatibility of the hydrogels.
33662416	5	47	theme	CCDK	1025:1028	arg1	cells					1031:1035	human skin fibroblast (CCDK) cells	1002:1035	human skin fibroblast (CCDK) cells	1002:1035	The biocompatibility of PCNCHFs was tested against human skin fibroblast (CCDK) cells.
33662416	8	48	theme	drug	1288:1291	arg1	release					1293:1299	drug release	1288:1299	drug release in cancer therapy	1288:1317	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	3	49	dep	properties	824:833	arg1	melting-transition					847:864	melting-transition	847:864	melting-transition	847:864	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	3	49	dep	properties	824:833	arg1	glass-					836:841	glass-	836:841	glass-	836:841	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	7	50	theme	cells	1173:1177	arg1	proliferation					1145:1157	the proliferation	1141:1157	the proliferation of fibroblast cells	1141:1177	The live/dead assay show the proliferation of fibroblast cells, confirming the biocompatibility of the hydrogels.
33662416	3	51	theme	PCNCHF1	698:704	arg1	composites					686:695	The nanosepiolite-loaded polymer composites	653:695	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5)	653:716	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	3	51	theme	PCNCHF1	698:704	arg1	PCNCHF5					709:715	PCNCHF1 to PCNCHF5	698:715	PCNCHF1 to PCNCHF5	698:715	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	8	52	theme	cancer	1304:1309	arg1	therapy					1311:1317	cancer therapy	1304:1317	cancer therapy	1304:1317	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	2	53	theme	structural	602:611	arg1	properties					641:650	their structural, morphological, and thermal properties	596:650	their structural, morphological, and thermal properties	596:650	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	1	54	theme	Polymer-clay	159:170	arg1	films					195:199	Polymer-clay nanocomposite hydrogel films	159:199	Polymer-clay nanocomposite hydrogel films (PCNCHFs)	159:209	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	1	54	theme	Polymer-clay	159:170	arg1	PCNCHFs					202:208	PCNCHFs	202:208	PCNCHFs	202:208	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	3	55	theme	higher	728:733	arg1	strength					743:750	higher tensile strength	728:750	higher tensile strength	728:750	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	8	56	theme	developed	1328:1336	arg1	PCNCHFs					1338:1344	the developed PCNCHFs	1324:1344	the developed PCNCHFs	1324:1344	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	8	56	theme	developed	1328:1336	arg1	useful					1358:1363	useful	1358:1363	useful	1358:1363	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	1	57	theme	inexpensive	397:407	arg1	route					409:413	a simple, rapid, and inexpensive route	376:413	a simple, rapid, and inexpensive route	376:413	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	1	58	theme	nanocomposite	172:184	arg1	films					195:199	Polymer-clay nanocomposite hydrogel films	159:199	Polymer-clay nanocomposite hydrogel films (PCNCHFs)	159:209	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	1	58	theme	nanocomposite	172:184	arg1	PCNCHFs					202:208	PCNCHFs	202:208	PCNCHFs	202:208	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	3	59	theme	polymer	770:776	arg1	PCNCHF0					788:794	PCNCHF0	788:794	PCNCHF0	788:794	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	3	59	theme	polymer	770:776	arg1	hydrogel					778:785	the pristine polymer hydrogel	757:785	the pristine polymer hydrogel (PCNCHF0)	757:795	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	3	60	theme	tensile	735:741	arg1	strength					743:750	higher tensile strength	728:750	higher tensile strength	728:750	The nanosepiolite-loaded polymer composites (PCNCHF1 to PCNCHF5) exhibited higher tensile strength than the pristine polymer hydrogel (PCNCHF0); consequently, the thermal properties (glass- and melting-transition) were improved.
33662416	4	61	theme	@	893:893	arg1	FU					894:895	The PCNCHFs@FU	882:895	The PCNCHFs@FU	882:895	The PCNCHFs@FU demonstrated prolonged FU release at pH 7.4 for 32 h.
33662416	5	62	theme	PCNCHFs	975:981	arg1	biocompatibility					955:970	The biocompatibility	951:970	The biocompatibility of PCNCHFs	951:981	The biocompatibility of PCNCHFs was tested against human skin fibroblast (CCDK) cells.
33662416	1	63	theme	hydrogel	186:193	arg1	films					195:199	Polymer-clay nanocomposite hydrogel films	159:199	Polymer-clay nanocomposite hydrogel films (PCNCHFs)	159:209	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	1	63	theme	hydrogel	186:193	arg1	PCNCHFs					202:208	PCNCHFs	202:208	PCNCHFs	202:208	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	4	64	theme	PCNCHFs	886:892	arg1	FU					894:895	The PCNCHFs@FU	882:895	The PCNCHFs@FU	882:895	The PCNCHFs@FU demonstrated prolonged FU release at pH 7.4 for 32 h.
33662416	8	65	theme	tissue	1369:1374	arg1	engineering					1376:1386	tissue engineering	1369:1386	tissue engineering	1369:1386	The pH-sensitive PCNCHFs@FU release could be suitable for drug release in cancer therapy, and the developed PCNCHFs may also be useful for tissue engineering, food packaging, and other biological applications.
33662416	2	66	theme	thermal	633:639	arg1	properties					641:650	their structural, morphological, and thermal properties	596:650	their structural, morphological, and thermal properties	596:650	The PCNCHFs and its 5-fluorouracil (FU)-loaded composites (PCNCHFs@FU) were tested for FU release and characterized by FTIR, XRD, FE-SEM, EDX, DSC, and TGA analyses to investigate their structural, morphological, and thermal properties.
33662416	1	67	theme	nanosepiolite	285:297	arg1	reinforcement					336:348	0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement	305:348	0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement	305:348	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
33662416	1	67	theme	nanosepiolite	285:297	arg1	clay					299:302	nanosepiolite clay	285:302	nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement)	285:349	Polymer-clay nanocomposite hydrogel films (PCNCHFs) were prepared from caboxymethyl cellulose, polyvinylpyrrolidone, agar and nanosepiolite clay (0, 0.3, 0.5, 0.7, 0.9 and 1.5% reinforcement) by treating thermally in a simple, rapid, and inexpensive route.
34168199	11	0	theme	host	1595:1598	arg1	system					1607:1612	the host immune system	1591:1612	the host immune system	1591:1612	Reduction of MN production may assist in the eradication of biofilms by the host immune system in clinical situations.
34168199	5	1	theme	inhibitory	662:671	arg1	concentrations					673:686	sub-minimum inhibitory concentrations	650:686	sub-minimum inhibitory concentrations of antimicrobials	650:704	MN expression can be modulated by sub-minimum inhibitory concentrations of antimicrobials.
34168199	0	2	theme	biofilm	89:95	arg1	formation					97:105	biofilm formation	89:105	biofilm formation	89:105	Influence of sub-inhibitory concentrations of antimicrobials on micrococcal nuclease and biofilm formation in Staphylococcus aureus.
34168199	4	3	dep	contributes	539:549	arg1	expressed					597:605	expressed	597:605	expressed by nuc1	597:613	S. aureus also produces micrococcal nuclease (MN), an endonuclease which contributes to biofilm composition and dispersion, mainly expressed by nuc1.
34168199	8	4	theme	total	1059:1063	arg1	biomass					1065:1071	total biomass	1059:1071	total biomass of the biofilm	1059:1086	Results do not confirm earlier findings that MN directly influences total biomass of the biofilm but indicated that nuc1 deletion stimulates the polysaccharide production per CFU in the biofilm in in vitro biofilms.
34168199	11	5	theme	immune	1600:1605	arg1	system					1607:1612	the host immune system	1591:1612	the host immune system	1591:1612	Reduction of MN production may assist in the eradication of biofilms by the host immune system in clinical situations.
34168199	8	6	dep	in	1188:1189	arg1	vitro					1191:1195	vitro	1191:1195	vitro	1191:1195	Results do not confirm earlier findings that MN directly influences total biomass of the biofilm but indicated that nuc1 deletion stimulates the polysaccharide production per CFU in the biofilm in in vitro biofilms.
34168199	7	7	theme	strains	903:909	arg1	cultures					875:882	Planktonic and biofilm cultures	852:882	Planktonic and biofilm cultures of three S. aureus strains, including a nuc1 deficient strain,	852:945	Planktonic and biofilm cultures of three S. aureus strains, including a nuc1 deficient strain, were cultured under antimicrobial pressure.
34168199	10	8	theme	total	1489:1493	arg1	biomass					1495:1501	total biomass	1489:1501	total biomass	1489:1501	Erythromycin and resveratrol significantly reduced MN production per CFU but did not affect total biomass or biomass/CFU.
34168199	0	9	from	Influence	0:8	arg1	nuclease					76:83	micrococcal nuclease	64:83	micrococcal nuclease	64:83	Influence of sub-inhibitory concentrations of antimicrobials on micrococcal nuclease and biofilm formation in Staphylococcus aureus.
34168199	0	9	from	Influence	0:8	arg1	formation					97:105	biofilm formation	89:105	biofilm formation	89:105	Influence of sub-inhibitory concentrations of antimicrobials on micrococcal nuclease and biofilm formation in Staphylococcus aureus.
34168199	5	10	theme	MN	616:617	arg1	expression					619:628	MN expression	616:628	MN expression	616:628	MN expression can be modulated by sub-minimum inhibitory concentrations of antimicrobials.
34168199	11	11	from	eradication	1564:1574	arg1	situations					1626:1635	clinical situations	1617:1635	clinical situations	1617:1635	Reduction of MN production may assist in the eradication of biofilms by the host immune system in clinical situations.
34168199	8	12	theme	in	1188:1189	arg1	biofilms					1197:1204	in vitro biofilms	1188:1204	in vitro biofilms	1188:1204	Results do not confirm earlier findings that MN directly influences total biomass of the biofilm but indicated that nuc1 deletion stimulates the polysaccharide production per CFU in the biofilm in in vitro biofilms.
34168199	5	13	theme	antimicrobials	691:704	arg1	concentrations					673:686	sub-minimum inhibitory concentrations	650:686	sub-minimum inhibitory concentrations of antimicrobials	650:704	MN expression can be modulated by sub-minimum inhibitory concentrations of antimicrobials.
34168199	6	14	from	relation	727:734	arg1	relation					842:849	this relation	837:849	this relation	837:849	We investigated the relation between the biofilm and MN expression and the impact of the application of antimicrobial pressure on this relation.
34168199	6	15	theme	biofilm	748:754	arg1	expression					763:772	the biofilm and MN expression	744:772	expression	763:772	We investigated the relation between the biofilm and MN expression and the impact of the application of antimicrobial pressure on this relation.
34168199	3	16	theme	polymeric	372:380	arg1	substances					382:391	extracellular polymeric substances	358:391	extracellular polymeric substances (EPS) comprising polysaccharides, proteins and extracellular DNA (eDNA)	358:463	Biofilms are composed of bacteria encapsulated in a matrix of extracellular polymeric substances (EPS) comprising polysaccharides, proteins and extracellular DNA (eDNA).
34168199	3	16	theme	polymeric	372:380	arg1	EPS					394:396	EPS	394:396	EPS	394:396	Biofilms are composed of bacteria encapsulated in a matrix of extracellular polymeric substances (EPS) comprising polysaccharides, proteins and extracellular DNA (eDNA).
34168199	4	17	theme	micrococcal	490:500	arg1	MN					512:513	MN	512:513	MN	512:513	S. aureus also produces micrococcal nuclease (MN), an endonuclease which contributes to biofilm composition and dispersion, mainly expressed by nuc1.
34168199	4	17	theme	micrococcal	490:500	arg1	nuclease					502:509	micrococcal nuclease	490:509	micrococcal nuclease (MN)	490:514	S. aureus also produces micrococcal nuclease (MN), an endonuclease which contributes to biofilm composition and dispersion, mainly expressed by nuc1.
34168199	4	17	theme	micrococcal	490:500	arg1	endonuclease					520:531	an endonuclease	517:531	an endonuclease which contributes to biofilm composition and dispersion, mainly expressed by nuc1	517:613	S. aureus also produces micrococcal nuclease (MN), an endonuclease which contributes to biofilm composition and dispersion, mainly expressed by nuc1.
34168199	8	18	theme	earlier	1014:1020	arg1	findings					1022:1029	earlier findings	1014:1029	earlier findings	1014:1029	Results do not confirm earlier findings that MN directly influences total biomass of the biofilm but indicated that nuc1 deletion stimulates the polysaccharide production per CFU in the biofilm in in vitro biofilms.
34168199	7	19	theme	aureus	896:901	arg1	strains					903:909	three S. aureus strains	887:909	three S. aureus strains	887:909	Planktonic and biofilm cultures of three S. aureus strains, including a nuc1 deficient strain, were cultured under antimicrobial pressure.
34168199	7	19	theme	aureus	896:901	arg1	strain					939:944	a nuc1 deficient strain	922:944	a nuc1 deficient strain	922:944	Planktonic and biofilm cultures of three S. aureus strains, including a nuc1 deficient strain, were cultured under antimicrobial pressure.
34168199	3	20	theme	substances	382:391	arg1	matrix					348:353	a matrix	346:353	a matrix of extracellular polymeric substances (EPS) comprising polysaccharides, proteins and extracellular DNA (eDNA)	346:463	Biofilms are composed of bacteria encapsulated in a matrix of extracellular polymeric substances (EPS) comprising polysaccharides, proteins and extracellular DNA (eDNA).
34168199	9	21	theme	reduced	1376:1382	arg1	activity					1387:1394	significantly reduced MN activity	1362:1394	significantly reduced MN activity	1362:1394	Though antimicrobial pressure of certain antibiotics resulted in significantly increased quantities of polysaccharides per CFU, this did not coincide with significantly reduced MN activity.
34168199	0	22	theme	antimicrobials	46:59	arg1	concentrations					28:41	sub-inhibitory concentrations	13:41	sub-inhibitory concentrations of antimicrobials	13:59	Influence of sub-inhibitory concentrations of antimicrobials on micrococcal nuclease and biofilm formation in Staphylococcus aureus.
34168199	6	23	theme	pressure	825:832	arg1	application					796:806	the application	792:806	the application of antimicrobial pressure	792:832	We investigated the relation between the biofilm and MN expression and the impact of the application of antimicrobial pressure on this relation.
34168199	9	24	theme	MN	1384:1385	arg1	activity					1387:1394	significantly reduced MN activity	1362:1394	significantly reduced MN activity	1362:1394	Though antimicrobial pressure of certain antibiotics resulted in significantly increased quantities of polysaccharides per CFU, this did not coincide with significantly reduced MN activity.
34168199	6	25	theme	antimicrobial	811:823	arg1	pressure					825:832	antimicrobial pressure	811:832	antimicrobial pressure	811:832	We investigated the relation between the biofilm and MN expression and the impact of the application of antimicrobial pressure on this relation.
34168199	5	26	theme	sub-minimum	650:660	arg1	concentrations					673:686	sub-minimum inhibitory concentrations	650:686	sub-minimum inhibitory concentrations of antimicrobials	650:704	MN expression can be modulated by sub-minimum inhibitory concentrations of antimicrobials.
34168199	7	27	theme	biofilm	867:873	arg1	cultures					875:882	Planktonic and biofilm cultures	852:882	Planktonic and biofilm cultures of three S. aureus strains, including a nuc1 deficient strain,	852:945	Planktonic and biofilm cultures of three S. aureus strains, including a nuc1 deficient strain, were cultured under antimicrobial pressure.
34168199	9	28	theme	increased	1286:1294	arg1	quantities					1296:1305	significantly increased quantities	1272:1305	significantly increased quantities of polysaccharides per CFU	1272:1332	Though antimicrobial pressure of certain antibiotics resulted in significantly increased quantities of polysaccharides per CFU, this did not coincide with significantly reduced MN activity.
34168199	0	29	theme	concentrations	28:41	arg1	Influence					0:8	Influence	0:8	Influence of sub-inhibitory concentrations of antimicrobials on micrococcal nuclease and biofilm formation in Staphylococcus aureus.	0:131	Influence of sub-inhibitory concentrations of antimicrobials on micrococcal nuclease and biofilm formation in Staphylococcus aureus.
34168199	6	30	theme	application	796:806	arg1	impact					782:787	the impact	778:787	the impact of the application of antimicrobial pressure on this relation	778:849	We investigated the relation between the biofilm and MN expression and the impact of the application of antimicrobial pressure on this relation.
34168199	6	30	theme	application	796:806	arg1	relation					727:734	the relation	723:734	the relation between the biofilm and MN expression	723:772	We investigated the relation between the biofilm and MN expression and the impact of the application of antimicrobial pressure on this relation.
34168199	11	31	theme	production	1535:1544	arg1	Reduction					1519:1527	Reduction	1519:1527	Reduction of MN production	1519:1544	Reduction of MN production may assist in the eradication of biofilms by the host immune system in clinical situations.
34168199	0	32	theme	sub-inhibitory	13:26	arg1	concentrations					28:41	sub-inhibitory concentrations	13:41	sub-inhibitory concentrations of antimicrobials	13:59	Influence of sub-inhibitory concentrations of antimicrobials on micrococcal nuclease and biofilm formation in Staphylococcus aureus.
34168199	8	33	theme	nuc1	1107:1110	arg1	deletion					1112:1119	nuc1 deletion	1107:1119	nuc1 deletion	1107:1119	Results do not confirm earlier findings that MN directly influences total biomass of the biofilm but indicated that nuc1 deletion stimulates the polysaccharide production per CFU in the biofilm in in vitro biofilms.
34168199	0	34	from	formation	97:105	arg1	aureus					125:130	Staphylococcus aureus	110:130	Staphylococcus aureus	110:130	Influence of sub-inhibitory concentrations of antimicrobials on micrococcal nuclease and biofilm formation in Staphylococcus aureus.
34168199	7	35	theme	Planktonic	852:861	arg1	cultures					875:882	Planktonic and biofilm cultures	852:882	Planktonic and biofilm cultures of three S. aureus strains, including a nuc1 deficient strain,	852:945	Planktonic and biofilm cultures of three S. aureus strains, including a nuc1 deficient strain, were cultured under antimicrobial pressure.
34168199	11	36	theme	MN	1532:1533	arg1	production					1535:1544	MN production	1532:1544	MN production	1532:1544	Reduction of MN production may assist in the eradication of biofilms by the host immune system in clinical situations.
34168199	3	37	theme	extracellular	440:452	arg1	eDNA					459:462	eDNA	459:462	eDNA	459:462	Biofilms are composed of bacteria encapsulated in a matrix of extracellular polymeric substances (EPS) comprising polysaccharides, proteins and extracellular DNA (eDNA).
34168199	3	37	theme	extracellular	440:452	arg1	DNA					454:456	extracellular DNA	440:456	extracellular DNA (eDNA)	440:463	Biofilms are composed of bacteria encapsulated in a matrix of extracellular polymeric substances (EPS) comprising polysaccharides, proteins and extracellular DNA (eDNA).
34168199	8	38	from	biofilm	1177:1183	arg1	biofilms					1197:1204	in vitro biofilms	1188:1204	in vitro biofilms	1188:1204	Results do not confirm earlier findings that MN directly influences total biomass of the biofilm but indicated that nuc1 deletion stimulates the polysaccharide production per CFU in the biofilm in in vitro biofilms.
34168199	2	39	theme	protective	246:255	arg1	biofilm					257:263	a protective biofilm	244:263	a protective biofilm	244:263	This pathogen produces a protective biofilm, making eradication difficult.
34168199	7	40	theme	S.	893:894	arg1	strains					903:909	three S. aureus strains	887:909	three S. aureus strains	887:909	Planktonic and biofilm cultures of three S. aureus strains, including a nuc1 deficient strain, were cultured under antimicrobial pressure.
34168199	7	40	theme	S.	893:894	arg1	strain					939:944	a nuc1 deficient strain	922:944	a nuc1 deficient strain	922:944	Planktonic and biofilm cultures of three S. aureus strains, including a nuc1 deficient strain, were cultured under antimicrobial pressure.
34168199	0	41	theme	micrococcal	64:74	arg1	nuclease					76:83	micrococcal nuclease	64:83	micrococcal nuclease	64:83	Influence of sub-inhibitory concentrations of antimicrobials on micrococcal nuclease and biofilm formation in Staphylococcus aureus.
34168199	0	42	from	nuclease	76:83	arg1	aureus					125:130	Staphylococcus aureus	110:130	Staphylococcus aureus	110:130	Influence of sub-inhibitory concentrations of antimicrobials on micrococcal nuclease and biofilm formation in Staphylococcus aureus.
34168199	6	43	from	impact	782:787	arg1	relation					842:849	this relation	837:849	this relation	837:849	We investigated the relation between the biofilm and MN expression and the impact of the application of antimicrobial pressure on this relation.
34168199	4	44	theme	biofilm	554:560	arg1	composition					562:572	biofilm composition	554:572	biofilm composition	554:572	S. aureus also produces micrococcal nuclease (MN), an endonuclease which contributes to biofilm composition and dispersion, mainly expressed by nuc1.
34168199	8	45	theme	polysaccharide	1136:1149	arg1	production					1151:1160	the polysaccharide production	1132:1160	the polysaccharide production per CFU	1132:1168	Results do not confirm earlier findings that MN directly influences total biomass of the biofilm but indicated that nuc1 deletion stimulates the polysaccharide production per CFU in the biofilm in in vitro biofilms.
34168199	9	46	theme	polysaccharides	1310:1324	arg1	quantities					1296:1305	significantly increased quantities	1272:1305	significantly increased quantities of polysaccharides per CFU	1272:1332	Though antimicrobial pressure of certain antibiotics resulted in significantly increased quantities of polysaccharides per CFU, this did not coincide with significantly reduced MN activity.
34168199	8	47	theme	biofilm	1080:1086	arg1	biomass					1065:1071	total biomass	1059:1071	total biomass of the biofilm	1059:1086	Results do not confirm earlier findings that MN directly influences total biomass of the biofilm but indicated that nuc1 deletion stimulates the polysaccharide production per CFU in the biofilm in in vitro biofilms.
34168199	1	48	theme	major	135:139	arg1	contributor					141:151	A major contributor	133:151	A major contributor to biomaterial associated infection (BAI)	133:193	A major contributor to biomaterial associated infection (BAI) is Staphylococcus aureus.
34168199	1	48	theme	major	135:139	arg1	aureus					213:218	Staphylococcus aureus	198:218	Staphylococcus aureus	198:218	A major contributor to biomaterial associated infection (BAI) is Staphylococcus aureus.
34168199	11	49	theme	clinical	1617:1624	arg1	situations					1626:1635	clinical situations	1617:1635	clinical situations	1617:1635	Reduction of MN production may assist in the eradication of biofilms by the host immune system in clinical situations.
34168199	9	50	theme	certain	1240:1246	arg1	antibiotics					1248:1258	certain antibiotics	1240:1258	certain antibiotics	1240:1258	Though antimicrobial pressure of certain antibiotics resulted in significantly increased quantities of polysaccharides per CFU, this did not coincide with significantly reduced MN activity.
34168199	9	51	theme	antimicrobial	1214:1226	arg1	pressure					1228:1235	antimicrobial pressure	1214:1235	antimicrobial pressure of certain antibiotics	1214:1258	Though antimicrobial pressure of certain antibiotics resulted in significantly increased quantities of polysaccharides per CFU, this did not coincide with significantly reduced MN activity.
34168199	10	52	theme	MN	1448:1449	arg1	production					1451:1460	MN production	1448:1460	MN production	1448:1460	Erythromycin and resveratrol significantly reduced MN production per CFU but did not affect total biomass or biomass/CFU.
34168199	7	53	theme	antimicrobial	967:979	arg1	pressure					981:988	antimicrobial pressure	967:988	antimicrobial pressure	967:988	Planktonic and biofilm cultures of three S. aureus strains, including a nuc1 deficient strain, were cultured under antimicrobial pressure.
34168199	1	54	theme	biomaterial	156:166	arg1	BAI					190:192	BAI	190:192	BAI	190:192	A major contributor to biomaterial associated infection (BAI) is Staphylococcus aureus.
34168199	1	54	theme	biomaterial	156:166	arg1	infection					179:187	biomaterial associated infection	156:187	biomaterial associated infection (BAI)	156:193	A major contributor to biomaterial associated infection (BAI) is Staphylococcus aureus.
34168199	7	55	theme	deficient	929:937	arg1	strain					939:944	a nuc1 deficient strain	922:944	a nuc1 deficient strain	922:944	Planktonic and biofilm cultures of three S. aureus strains, including a nuc1 deficient strain, were cultured under antimicrobial pressure.
34168199	9	56	theme	antibiotics	1248:1258	arg1	pressure					1228:1235	antimicrobial pressure	1214:1235	antimicrobial pressure of certain antibiotics	1214:1258	Though antimicrobial pressure of certain antibiotics resulted in significantly increased quantities of polysaccharides per CFU, this did not coincide with significantly reduced MN activity.
34168199	3	57	theme	extracellular	358:370	arg1	substances					382:391	extracellular polymeric substances	358:391	extracellular polymeric substances (EPS) comprising polysaccharides, proteins and extracellular DNA (eDNA)	358:463	Biofilms are composed of bacteria encapsulated in a matrix of extracellular polymeric substances (EPS) comprising polysaccharides, proteins and extracellular DNA (eDNA).
34168199	3	57	theme	extracellular	358:370	arg1	EPS					394:396	EPS	394:396	EPS	394:396	Biofilms are composed of bacteria encapsulated in a matrix of extracellular polymeric substances (EPS) comprising polysaccharides, proteins and extracellular DNA (eDNA).
34168199	6	58	theme	MN	760:761	arg1	expression					763:772	the biofilm and MN expression	744:772	expression	763:772	We investigated the relation between the biofilm and MN expression and the impact of the application of antimicrobial pressure on this relation.
34168199	1	59	theme	associated	168:177	arg1	BAI					190:192	BAI	190:192	BAI	190:192	A major contributor to biomaterial associated infection (BAI) is Staphylococcus aureus.
34168199	1	59	theme	associated	168:177	arg1	infection					179:187	biomaterial associated infection	156:187	biomaterial associated infection (BAI)	156:193	A major contributor to biomaterial associated infection (BAI) is Staphylococcus aureus.
34168199	11	60	theme	biofilms	1579:1586	arg1	eradication					1564:1574	the eradication	1560:1574	the eradication of biofilms by the host immune system in clinical situations	1560:1635	Reduction of MN production may assist in the eradication of biofilms by the host immune system in clinical situations.